lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MYAQLRTAHYRAPRSLRPQPQRRLLATPPPPPPPASGLPPNPPPPTGVVHPRPAVAHAKPPAVPGSSTVARPPPGRPRRFRRVFVYTALGVAGFYALSGYVGTKSDAYRDLFTQYVPGGEAVADYADDNDWDNVSGKAVRAWQSITGARPETRTEKVERKIGEVRQEAAKVPAQVKDKADEAKDHVVGKHTASQKIHERAEELRKAVEQKTHEAEARLKELTGEAKHKVQEATKDAPFNFSEGVEGIVRAAESALHKTEHKAAEAADKVKPAEARPSSPFPDTQRPRELKPETVTPQVPSYEGKKLYTGPPLPLGHEPPPGYYLPPPPSTKKEKVEEKVEEIKERLPLLVPKVKEFASEEPIISQLASTIDSLTSSLSTPSKALSSDATGILNKAQDDLTALNARLQEVKKAEKAKLEQSISEKKKEFEALLKSMEAEKAKSEEGLKQTWQHERQTMVEDWRKELEGELEQQRQSIEQRLREEVVSQGIELQRRWLRSIKTQVETERGGRLAKLDSLTTSLKQLERITLDNSATLDDNVRLHKIWSALRAVQSKVDSGDLAFDDELRALKSLSTPTASSGEGVVRSALEQIEKSGIPQTGVKSFAALSSWFTNTVAPRIQSSSLVPAPEEATVISHLASAGLSKIMFRPQAGRVPGDSVGAVLARAEWCLAEKDLDGAAREINSLTGWPAKLANDWLQQARRKLEVQQALEVVATEATLSSLLLV
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLADPHLSTSHVNYSLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQTEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSILKNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDFYLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEYHGKEHKADAAQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFKYLLSVRRVQAELQHCWALQMQRKHLKSNQTDAVKWRLRNHMAFLVDNLQYYLQVDVLESQFSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQNLGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGGTLGSFGM
The following text describes a protein:
Function:
Involved in the organization of desmosome cell-cell junctions. Of particular importance in cell adhesion in the skin and during cardiac development. May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways.
Subcellular Localization:
Cell junction, desmosome. Cell membrane.
Sequence:
MKPCAVNQRNGTEMCPPVIRKRFLSDCRRRPTQRRLRGNQKIIIMKSETTPCCLLLSASLSLCRRRGGDAPCPFPVQQHSCNKTHGEIMSLTGSNPNLTTMGRRSNSRQDLAFSRNDMGRFGGNGYQGDYAVEGGYAHKSFSRHTVAGGGGGGGTMKVPMAMAMGSAGPSSQMLLQKSDYLMNQCMDYLERAKMLSGSGGSSMEANKCLEMAAEGMRQLHSCARDLQLMGIQHDYFRQVEYFQDVHSSLQQRMYSSGTMKGNRGSVGSDGARLFQDAMAWIAQQKRMIETAPWGEDSQAIENQIISHNKFHTSIQRSQEVNRAMEEVMSDKNLSLILEQEFDSLKKMSLNRLTQLRDLQNIIEEIFKAIMWVNEKEEEELMFDWGDKNIDQYIPKKQESYSRLMRDLEEKEKELNKLKVKADALLNKGHPASDKIEAYMETLQTQWSWLLQITKCIEVHLKENSSYSQFFKEANETNARLQKEHEMIRSNYICDKSTPLERLTELLKTLEKDKERIMENKRQVQSLLSKSKSIVRLKPRNPEEKSSSSIMVQALCDFKQDQKGILKGNEGILKDNSQRSKWLVTGPGGLDMTIPSVCLLIPPPNPLSINLATKNEKFYEAIMNIWNQLNINIKSLISWQYCIKDISYINSLTLTMLSKMRPEEYRGVIKRLETTYQEFLRTSQGSEMFKEEDKKNLQGHFDRAQEHYDTLVVQLPNYQEKEVKIVTTNESSKVTQETQETIPKAKPQPPAATINLALLTSLQELRQRLEVTESGLTDHLHLPMGDNSLHQCSVHIQKLQNVHKDLESIHDEYLRVRESISNQLKGLPADSDQAKFLRSQLGIINQKIGILQGLYTVYIQRLSAMKALLQSLLQAEDTIKAHEARLTEKETSSLDLRELENQRCTLKHMRNDLEQKRGLLTAMDSDLAKAIHCNSQITESFHRCDVDLSKYSDQVNQMGDRWRRILKQIESRIWDLDKQEKQLIQYQQSSSTLEQWLENARKRQDALQLVKLNDIQTLMNHLNQQKALHNEIKGKREKVEDVQKSADTCASSIKDYELQLASYGSGLETLLNVPIKRTMLQSPASVVRQEAADHQTHYIELLTRSTDYYKYLGELLKNMEEMKLSNTRIELLEEELRRLKEDLQDRNERNKSLEDTLARYKLELSQSKDELCSIEEVKRTTAMQVNAAKESLGSTQCQIQDLNEQLTRIQYQLDEEKRKRRLAEERYTSQQEEYEAAVRRRQKELEELNWLKIDLEKSVKDKERELERLKIQLDDEAARRRNAESEISKTSMMVHMSQSQYNELLLEKDSLLAKLKLMEQDKNRNKQLEDELATIRRSLEMEIRNKKRLEDEKNSMLSEFNTIKFQYEQKTTQIRQSESDREKVDRERLSLKTEIERLRHELKCLEEKYRSKLTISEKEASELAKKIDSLQREIQRLQQRPSTLCRQTQTDEKVTTIDPSKLVFDGVRRKVTAHQLCDCSIISKATLEELLKGRKTVDEVAAGIQLSLKGSGVIAGMTTGSEGKVSFTEAKHKNLLSPESALKLLEAQAATGYIVDPAFNMTMTVDTACSRGLVDTEDRDTLVTAEAASTGFKDPYTGKILSVGQAYKQGHVDKTTAVRLLQAQECVGGILDPVLSVFLPKDLALDRNLIDEDLYRCLNKKPTSYLDPATDEKVSYGDLRKKCTCEPVSGLLLLRGKEKCMTVKGIRGEVPVSELIKAELLDETDMKKLNQGQLSSKDIEEKLKSYLHGSTCIAGIYDEADNRIMTFYMAMKEGLLMRGTTLELLEAQAASGFIVDPVNNVFLTVEEAAKRGIIGKEFKNKLLSAEKAVTGYKDPATGKTVSLFQAIEKGLIEEGHGIRLLEAQIASGGIIDPVESHRIDVSVAYKRGYFDEKMNEILSYEGDDTKGFFDPNTKENLTYLQLKARCTTDPQTGLILLPIKDKNRPKSPNEERTNVLRKRRVVIVDPDTGLEMTVREAYHKELIDYETFLDLSEQESEWEEITIKGSDGSARLVIVDRKTGAQYDIQDCLDRGVIDKGFLDQYRSGKLGLTQFGEGIVSRTNNPGMIIATSSVDDVVTCSSPTQARPSSPTVRKRFNSISITVSPPPMFDDHSPVGAIFDTETLEKITIPEALRRGIVDTLTAQRLLEAQACTGGIINPATGDRLSLEDAVHQSIIDESMAAKLKAAQKAYLGFEDVKTKRKMSAAEAVKEAWLPYEAGQRFLEYQYLTGGLVDPSTRQRITIEEAIRKRWLDGMGAQKLQDYRSHQKNLTCPKTKLKISYKDAMDKCMVEESNGMKMLQASSISSKGISSPYNVSNPGSRSGSRPGSRSGSRRGSVDYSSSYSYNFSSSSTSYSANVPS
The following text describes a protein:
Function:
Involved in the regulation of pedicel length and of CLAVATA pathways controlling stem cell identity at shoot and flower meristems.
Subcellular Localization:
Nucleus.
Domain:
The conserved PP2C phosphatase domain (257-736) is interrupted by an insertion of approximately 200 amino acids.
Sequence:
MGSGFSSLLPCFNQGHRNRRRHSSAANPSHSDLIDSFREPLDETLGHSYCYVPSSSNRFISPFPSDRFVSPTASFRLSPPHEPGRIRGSGSSEQLHTGFRAISGASVSANTSNSKTVLQLEDIYDDATESSFGGGVRRSVVNANGFEGTSSFSALPLQPGPDRSGLFMSGPIERGATSGPLDPPAGEISRSNSAGVHFSAPLGGVYSKKRRKKKKKSLSWHPIFGGEKKQRPWVLPVSNFVVGAKKENIVRPDVEAMAASSGENDLQWALGKAGEDRVQLAVFEKQGWLFAGIYDGFNGPDAPEFLMANLYRAVHSELQGLFWELEEEDDNPTDISTRELEQQGEFEDHVNEMASSSCPATEKEEEEMGKRLTSSLEVVEVKERKRLWELLAEAQAEDALDLSGSDRFAFSVDDAIGAGNAVSVGSKRWLLLSKLKQGLSKQGISGRKLFPWKSGVEENETEEVDNVGVEEGVDKRRKRRKAGTVDHELVLKAMSNGLEATEQAFLEMTDKVLETNPELALMGSCLLVALMRDDDVYIMNIGDSRALVAQYQVEETGESVETAERVEERRNDLDRDDGNKEPLVVDSSDSTVNNEAPLPQTKLVALQLTTDHSTSIEDEVTRIKNEHPDDNHCIVNDRVKGRLKVTRAFGAGFLKQPKLNDALLEMFRNEYIGTDPYISCTPSLRHYRLTENDQFMVLSSDGLYQYLSNVEVVSLAMEKFPDGDPAQHVIQELLVRAAKKAGMDFHELLDIPQGDRRKYHDDCTVLVIALGGSRIWKSSGKYL
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
Sequence:
MSKPLQGEIALVTGASRGIGAAIADTLAAQGATVIGTATSASGAAAIGERLAANGGHGRELNVTDAAAVDALIDAIGKEFGAVSILVNNAGITRDNLLMRMKDDDWQAIIDTNLTSVFRTSKAVMRGMMKARKGRIINIASVVGVTGNPGQTNYAAAKAGIIAFSKSLAKEIGSRGITVNVVAPGFIDTDMTKALPEDAKTALLQQIALGHLGQPDDIANAVAFLAGPPARYITGETLHVNGGMYMP
The following text describes a protein:
Function:
Plays a major role in programmed cell death.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDETDPVPDMSLLPDTVPVVVSGDGSAAGIQLCPALILGSPQALPGAIKHIYSRLAAAASEVDQGVPDLIISLISHGNSLSTKYMSSVENGLKSFLIGCGTWLISSGEVNDPMSRVASGALKNVLPQLEHQAEVLHILVNSDDMIASDTTNSKSVVDTSLNTLLLICRKEPNDSYETVASSIAKLRAATAVKLAHPPPALLIGVPSEPMSPSTYGNSAAILLSPSNDKRPFPVAIFAGASKESLIELLFFVEHGIPVIILQDSCELCAILHSSHLLLETSNFDNDKFISWLRSQLYPLGLADCYTLITKLLVSSNSGDVQLIEFIDSSQLSELSSVVVDRCLECYATTGEERQVLLLAAKLNSPSVLSSMDVAAQLDEELLTMILCECITKDDQLHFLSSVLQLSPPIRVTSNMLIRMMHHADEHFFTTIVLCQCMGYSYIPSEIDPRFANDIQKLVKKLSFGVDNLFDPNVFCNDSSHRDKHESIRILAIWSLLLHRPGIVKCLAAFADEPVAFSMVLSRIARSLGHESHDWHFYEKSLNTLSDSLSGSATTLFDTVFSTSPAKAYQLLCQPMEYFYGFNMTQLAFHCNAREIIAHECCQRWVHRKLYGNLQAKNFPIFLPKWAKICISAVLIIPVKFWMLVRPRERTKQDTVSPTVALLDVGKFPQKQRAISTYSVISSRSEALTALTAPLSTAFGFNSALNGAESATPQSMVFPLNIEEIDKDPRPFGKKNRIRRAHAPTLSTFYSTPIVKYWLSLLFRIVFICCLAYSVVLPGCGSNLWDTGMWVWSFFWWIENCFVLTARARKIPLSLMPWRVFDVFAFFVFLILLLVMKVFPVTPVLEVLGIDSIYSAKVVSAFFVLYVSYSTLFTYIPLSDIFGPMIVRVKLMLLRDFTNFLFMIALVMLSSAVAIQAVVFPDRPVTMEVFRKTLSWIWLSLFTTDLSNLSESETCRKSFLGAPKRYCSSVGQYANPSCPSQSLPAYLIVIEYFVILKLLLWPILFAFFSKTAKNVDDEADKIWRFQLYSLAEDFRLRPPLPPPLTIFCLICSACCRFSNSFSGFFSDFDHPDFEARDKCRTTWKFGSIYRNPSVPFKRNEFVNSFWRKLSMEQWKNTQQKAKISANKSELQELHNIHNHIRMMTLRDSYENSGTRKASELQFFEKYPESNILKISVNMVSKPWTVLVPRYNPPFYCKPAEDFPSDVQKYVDIATEQNVGELKRIWRSRQANDVTSSNDKCWKLSAAGFPLNPNGRTGMAGRGNHPRFGANRRCYYVVLSGGVEAKCQVLVDSQKNIPNEWHLENSSKDEHLTSILKMIGISDSDAHMFSMRRLDSSIITADKRIPSNDTSPAHLASEVAENENDTDNAWTEHDVWAISLRERRIITTIIGYSWLPTSAIRGTVLPWQADLVFRAKTIYGL
The following text describes a protein:
Function:
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A; [Isoform 2]: Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1.
Subcellular Localization:
Mitochondrion.
Sequence:
MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
The following text describes a protein:
Function:
Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.
Subcellular Localization:
Nucleus.
Sequence:
MSSVMHYYPVHQAKVGSYSADPSEVKYSDLIYGHHHDVNPIGLPPNYNQMNSNPTTLNDHCSPQHVHQQHVSSDENLPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPREGTAAAEKRPMMAVAPVNPKPDYQASQKMKTEASTNNGMCSSADLSEILEHLAQTTAAPQVSTATSSTGTSTNSASSSSSGHYSYNVDLVLQSIKQDLEAAAQAWSKSKSAPILATQSWHPSSQSQVPTSVHAAPSMNLSWGEPAAKSRKLSVNHMNPCVTSYNYPN
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MEELLWRNLLRDISSFFSLSACGNFCSQSVHYQKIEEILKLLKPIADLILDSSIVPNEQRIKVLEQLVHSIKECSYLSEKWHPLASRIYLVIQAELLVKNIQTSILEIVQLLKDLPPFNSAELIPKCLENCFEKVKNMECESTCTFISESLKKQSSSHVLQRTEIAERLGLKSNQEILIEAVALKKLKENAGNDAEMDYLEQLITLLTRMHDDLLMLVQSKTGLPDYICPLSLEMMTDPVIVSSGVTYERVYIRHWLDLGLTVCPKTRQTLVHLNLIPNYTSKALIANWCEKNNVKLPDPMKSVNGQNMVNLRDIVKLDADSKVKRLVEDLKNKSSESLREATDQLLLFLMQNMDNRIIFANFGGIRLVVNLLYSNDVQTQENAVTALLYLAVNNGNKVAIADEDAIEPLIYILEVGTPKACENSAATLFCLSMIPVNKLRIGRLGAVVPLVELLRKGSPQGKNNAVIALFNLSISHENRVRIVQAGCVRFLVELLNIPSAGMADKAVAVLENLAKISEGRTAIGQAGGIRAFVNTVELGSPRAKGNAVSALVQLCTFSSIWFATMIQEAAVPPLVSLALSGVGTPRAKRKAAELLSYIRTQRHNIIRIPLNCIRNQRFIRS
The following text describes a protein:
Function:
Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (By similarity). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (By similarity). Probably involved in the side-chain initiation step of the polyglutamylation reaction rather than the elongation step (By similarity).
Domain:
Arg-218 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
Sequence:
MRGRDLCSSTQSQALGSLRTTTPAFTLNIPSEANHTEQPPAGLGARLQEAGVSIPPRRGRPTPTLEKKKKPHLMAEDEPSGALLKPLVFRVDETTPAVVQSVLLERGWNKFDKQEQNAEDWNLYWRTSSFRMTEHNSVKPWQQLNHHPGTTKLTRKDCLAKHLKHMRRMYGTSLYQFIPLTFVMPNDYTKFVAEYFQERQMLGTKHSYWICKPAELSRGRGILIFSDFKDFIFDDMYIVQKYISNPLLIGRYKCDLRIYVCVTGFKPLTIYVYQEGLVRFATEKFDLSNLQNNYAHLTNSSINKSGASYEKIKEVIGHGCKWTLSRFFSYLRSWDVDDLLLWKKIHRMVILTILAIAPSVPFAANCFELFGFDILIDDNLKPWLLEVNYSPALTLDCSTDVLVKRKLVHDIIDLIYLNGLRNEGREASNATHGNSNIDAAKSDRGGLDAPDCLPYDSLSFTSRMYNEDDSVVEKAVSVRPEAAPASQLEGEMSGQDFHLSTREMPQSKPKLRSRHTPHKTLMPYASLFQSHSCKTKTSPCVLSDRGKAPDPQAGNFVLVFPFNEATLGASRNGLNVKRIIQELQKLMNKQHS
The following text describes a protein:
Function:
Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPENKIPVLTRLSDEMTAVVNFQQPGLPPWPADGDIETQRQYYLLERRFWNADAPSMTTRTCAVPTPYGDVTTRLYSPQPTSQATLYYLHGGGFILGNLDTHDRIMRLLARYTGCTVIGIDYSLSPQARYPQAIEETVAVCSYFSQHADEYSLNVEKIGFAGDSAGAMLALASALWLRDKHIRCGNVIAILLWYGLYGLQDSVSRRLFGGAWDGLTREDLDMYEKAYLRNDEDRESPWYCLFNNDLTRDVPPCFIASAEFDPLIDDSRLLHQTLQAHQQPCEYKMYPGTLHAFLHYSRMMTIADDALQDGARFFMARMKTPR
The following text describes a protein:
Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Sequence:
MDGSLPKLYNAWFCPFAQRAWIAMLAKKAEFEYIEQNPYNKTPEWLAINPNGLVPVIVHNGNAVYESSICIEFIDEAFSTPVTILPKDPYKRAHGRMWGDFVSKKLVPHFYTMLLKQDKEDQEEAKTKYLEGLRTFTNEMDPEGPFFQGKHLGYVDIMWAPFAARMHILEHYRGFSVPQTDEFKRYHHWWDIIKRHSAVANTLQDEEKMLQVYQRYAFNTTRSQVSEAIRKGTALP
The following text describes a protein:
Function:
Involved in oxidative stress tolerance by detoxifying reactive aldehydes derived from lipid peroxidation. Medium- to long-chain saturated aldehydes are preferred substrates, while the short-chain aldehyde propanal is a weak substrate. Can use both NAD(+) and NADP(+), but the coenzyme preference is substrate dependent.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing ALDH3I1 show improved tolerance when exposed to dehydration, salt stress, heavy metals and H(2)O(2).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MTKLLEINHIQTLCFAKGFSPARLNVATSPFRISRRGGGGYCSNACIPYRLKFTCYATLSAVVKEQASDFSGKEAALLVDELRSNFNSGRTKSYEWRISQLQNIARMIDEKEKCITEALYQDLSKPELEAFLAEISNTKSSCMLAIKELKNWMAPETVKTSVTTFPSSAQIVSEPLGVVLVISAWNFPFLLSVEPVIGAIAAGNAVVLKPSEIAPAASSLLAKLFSEYLDNTTIRVIEGGVPETTALLDQKWDKIFFTGGARVARIIMAAAARNLTPVVLELGGKCPALVDSDVNLQVAARRIIAGKWACNSGQACIGVDYVITTKDFASKLIDALKTELETFFGQNALESKDLSRIVNSFHFKRLESMLKENGVANKIVHGGRITEDKLKISPTILLDVPEASSMMQEEIFGPLLPIITVQKIEDGFQVIRSKPKPLAAYLFTNNKELEKQFVQDVSAGGITINDTVLHVTVKDLPFGGVGESGIGAYHGKFSYETFSHKKGVLYRSFSGDADLRYPPYTPKKKMVLKALLSSNIFAAILAFFGFSKDS
The following text describes a protein:
Function:
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH (By similarity). In human cytomegalovirus, forms two distincts complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by interacting with host EPHA2. The gH-gL-UL128-UL130-UL131A pentamer is essential for viral entry in epithelial, endothelial and myeloid cells via interaction with host NRP2.
Subcellular Localization:
Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
Sequence:
MCRRPDCGFSFSPGPVILLWCCLLLPIVSSAAVSVAPTAAEKVPAECPELTRRCLLGEVFEGDKYESWLRPLVNVTGRDGPLSQLIRYRPVTPEAANSVLLDEAFLDTLALLYNNPDQLRALLTLLSSDTAPRWMTVMRGYSECGDGSPAVYTCVDDLCRGYDLTRLSYGRSIFTEHVLGFELVPPSLFNVVVAIRNEATRTNRAVRLPVSTAAAPEGITLFYGLYNAVKEFCLRHQLDPPLLRHLDKYYAGLPPELKQTRVNLPAHSRYGPQAVDAR
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
Subcellular Localization:
Cytoplasm. Nucleus speckle. Endoplasmic reticulum.
Domain:
The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins; The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Sequence:
MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MRKSNKVVQNRIEKVNSELLTLTYGAIVSQIIKDSDTVIEANEQLEKMGFNIGQRIIDEYLSKAEIKQCRDKIDVAENIGKGAMQMFLGVTAEVEVLPETDKIFTFNLHFTENPLNDFVELPEHLQGLNYSNMIAGAIRGALSTIHWIATCRFLKDQLKNDDKTILQVEMIREKFKDDE
The following text describes a protein:
Function:
A beta subtype methylase, recognizes the double-stranded sequence 5'-CAGCTG-3', methylates C-4 on both strands, and protects the DNA from cleavage by the PvuII endonuclease.
Sequence:
MMTLNLQTMSSNDMLNFGKKPAYTTSNGSMYIGDSLELLESFPDESISLVMTSPPFALQRKKEYGNLEQHEYVDWFLSFAKVVNKKLKPDGSFVVDFGGAYMKGVPARSIYNFRVLIRMIDEVGFFLAEDFYWFNPSKLPSPIEWVNKRKIRVKDAVNTVWWFSKTEWPKSDITKVLAPYSDRMKKLIEDPDKFYTPKTRPSGHDIGKSFSKDNGGSIPPNLLQISNSESNGQYLANCKLMGIKAHPARFPAKLPEFFIRMLTEPDDLVVDIFGGSNTTGLVAERESRKWISFEMKPEYVAASAFRFLDNNISEEKITDIYNRILNGESLDLNSII
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MELGGVVESLQNKTIFVTGATGFVAKIFVEKILRLQPNVKKLYLLLRAPDTKSATERLHNEVLEKEVFRVLRQKHGAGFDSFMSEKVIPVTGDITCDNLGLEDSDVRDEMWGEIDIVVNVAATVNFDERYDDALHVNTFGARNVLNFAKKCAKLQVFVHVSTAYVAGQQEGLILEKPYRMGETLNETSGLDIEQELKVAEERLKELQAQKLTKKEERIAMKELGLKRLGMDKFVQSHFVQKQPKIPGDLVVNSIIVAMVTHLNQPCESIYNVGSSVSHPTEFTLLQESAYRYFSMNPWMDKDEKPVKVGKVAVFSTMNEFHRYMTIRYLIPLKYPFLNQHFGCLPSAARTVHKLSLPLDTLAHVKEGIKLNSNEKKLVNKFTQLWDTLPYTHGGTHERQIRYHLSLVPLENNICSCWFIARTAIEXLWLQRSGEKSRNIHQRKNFGLLRQQIGKKSRLVLDVDNRLRDYLGGVWNRCCFSHAVLYXYAVFLENGFFFYLEPLLSQLVCWLGSSSEYADSNPVITTYSVQIREHGYAENSLGPQNSNPYKRVLCSVTQEAPLLSTIHPKCAQTIEKHKSMDLSTDDE
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Miscellaneous:
MISCELLANEOUS: Present with 19300 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLRTVTSKTVSNQFKRSLATAVATPKAEVTQLSNGIVVATEHNPSAHTASVGVVFGSGAANENPYNNGVSNLWKNIFLSKENSAVAAKEGLALSSNISRDFQSYIVSSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLKQVQDFEENDHPNRVLEHLHSTAFQNTPLSLPTRGTLESLENLVVADLESFANNHFLNSNAVVVGTGNIKHEDLVNSIESKNLSLQTGTKPVLKKKAAFLGSEVRLRDDTLPKAWISLAVEGEPVNSPNYFVAKLAAQIFGSYNAFEPASRLQGIKLLDNIQEYQLCDNFNHFSLSYKDSGLWGFSTATRNVTMIDDLIHFTLKQWNRLTISVTDTEVERAKSLLKLQLGQLYESGNPVNDANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKRLWDQDIAIAGTGQIEGLLDYMRIRSDMSMMRW
The following text describes a protein:
Function:
Involved in the regulation of exportin-mediated nuclear protein export. Required for resistance mediated by multiple R proteins and for the appropriate nuclear accumulation of SNC1 and of the downstream defense signaling components EDS1 and NPR1. Not involved in salt tolerance, ethylene and auxin responses, but required for systemic acquired resistance.
Subcellular Localization:
Nucleus envelope. Nucleus, nuclear pore complex.
Sequence:
MKFNFNETEDAPDSRRSPTPKEPVRWVPLQSHPVFASLPSSQDEPAVSQLFPRNFMAWDGDSRVYYWDSRRYLLHRLSLRLGEPEPSSVLAAVPSKVMQPDLQVTFSVSKISINKSGSAVLLAGSDGICVMYLFGRASVIEDNVICRVVSIGSEIYTSSDSAITLLQASWHPDSDTHLGILSSDAVFRLFDLSSDTELPEQEYYLQPGEPGRSRTASSIYPADFSFGGDHLWDRFTVFILFTDGSIYILCPVVPFGSVYKWESVMEIYNDANMYGVKSSNSLAVSNSSLAIEWLEATFPDLTEQGTRGENILVVKAQPYALLDASLALQGPLYKASSGDGDEDFAVREAECKGRAVSLLYNLVSKDSILVTAWSAGQLQVDALVDEIQPVWISGNSSRLRMNSHNKIQGVAMICESNISELPVATSNLPLDHTVWLGHPPPLLRLAMVDLALPKMREGGSLVTLFADSLLPERIYSLHDGGIDSTVLHSLPFTSQASGKDEALKTPSVHTVLSTCQEESAVSPLLGFVPLSDSFGYSWIVAVLSSGECIVAEMKTWDLLLPIHVSTDKTVSSSAIEKKEQENSCIISKELLAGPKIRIAPHALPNQRSTPANSVEGRSILLDYVKLFHENYIEYAHKVHFELQHHAPNLKRIIDDQHQRLAEANEKISKVEKNQSFLEKRIDKAIERHDSLEQCLQRLRSLPGTHKKPLTRAELDFKSELDQYAGVEVDALQSSIETLRARVKKSTQKSHKGTVVAASQKKQYSKKNLIQDTQMSQLQSTLAKLSLMNSDNSKKVKIVESALKSQESSFM
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MHTMNNPLDIAMDEIESWRNKASLFSRSDKLGNLLMSAFELMRTVLADGLHSQALPFKIKALSMECAAALDADTCQDDGARSFNYGYTASLCALLNWLSEQENCMHKDTGGVHKQRALEDTCLRSMSAMNNPLHTAMDEIESWRNKASLFSRSDKLGHLLMSAFELMRTVLADGMHSQALPFKIKALSMECAAALDADTCHDDGARSFNYGFTASMCALLTWLSESDNAIQCPNGRTDSGTNKRMTYDPLIDPSSPVDNLLELTNNGLHYDMNRPDSDPHGHDAPDPVEEDSDGVPNQMPYSHRRRRPILQRKENKRVHTIGKKKNSKKSVLNKLKNKPKTALKCNYCEKDFKRPFELNRHILIHTGEKPFSCELCDKKFTQIGTLYIHLRNTHGIEPKLPAQNNFDDRSLQCEYCTKKCGCPSKLIAHMRSHSGERPFECDECGKAFKLRGDLNRHGRDIHGITNAIGVTKNSRAS