lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone methyltransferase involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family. Required for histone H3 dimethylation on 'Lys-36' H3K36me2 at the FLC locus. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus. Involved in the control of seed dormancy and germination.
Subcellular Localization:
Nucleus.
Sequence:
MVAVDSTFPSHGSSYSSRRKKVSALEPNYFGSMCMGVYSDDVSISAREVAQDYSCDSCGDLATVSSACCNFDELCGLDSALEMGCRSNEDCRAGQEASGSGIASGLDKSVPGYTMYASGWMYGNQQGQMCGPYTQQQLYDGLSTNFLPEDLLVYPIINGYTANSVPLKYFKQFPDHVATGFAYLQNGIISVAPSVTSFPPSSSNATVHQDEIQTEHATSATHLISHQTMPPQTSSNGSVLDQLTLNHEESNMLASFLSLGNEHACWFLVDGEGRNHGPHSILELFSWQQHGYVSDAALIRDGENKLRPITLASLIGVWRVKCGDANCDEPVTGVNFISEVSEELSVHLQSGIMKIARRALLDEIISSVISDFLKAKKSDEHLKSYPPTSAVESISSRVINAEKSVVSNTESAGCKNTMNEGGHSSIAAESSKYTKSVGSIENFQTSCSAVCRTLHHHCMQIMWNAVFYDTVATHSSCWRKNKIWFRSSDISTVNYCKGSHTKYSDKPESFESFTCRVDSSSSKTAYSDEFDLATNGARVRGLSSDTYGTESVIASISEHVENELFLSLKTHLTDYTSILIKDGANNTTSSARDGKMHEGSFREQYNLEGSSKKKNGLNVVPAKLRFSNDFSDSQRLLQEGESSEQITSEDIIANIFSTALETSDIPVNDELDALAIHEPPPPGCESNINMPCLRYKYQPVRSKESIPEIKAYVSMALCRQKLHNDVMRDWKSLFLKCYLNEFLASLKGSHQVSRKETLALKKRKTVTRNKKLVQSNISNQTAEKLRKPCVGASEKVLVKRSKKLSDSHSMKEVLKVDTPSIDLSVRKPSQQKMRNTDRRDHCIIKDATKLHKEKVGKDAFSKVICDKSQDLEMEDEFDDALLITRLRRISRNKTKELRECRNAAKSCEEISVTAEESEETVDCKDHEESLSNKPSQKVKKAHTSKLKRKNLSDARDEGTKSCNGAVKSFTEISGKEGDTESLGLAISDKVSHQNLSKRRKSKIALFLFPGFENTSRKCFTKLLSPEDAAKNGQDMSNPTGNPPRLAEGKKFVEKSACSISQKGRKSSQSSILKRKHQLDEKISNVPSRRRLSLSSTDSEDAVIKEDYDVRNEEKLPCHTSDKLQKGPNKLIRRRKPLAKHTTERSPIKDLSVDDGRPKPIALKPLEKLSSKPSKKKLFLSIPKSDGCARTSINGWHWHAWSLKASAEERARVRGSSCVHMQHFGSKSSLTQNVLSARTNRAKLRNLLAAADGADVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPNVYCFCEQVPWIAKLKRRTWFSRRN
The following text describes a protein:
Function:
Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Cytoplasmic side. Cell membrane.
Sequence:
MRKDPIEWLLRGLYSALLYLLLPVTVYHLVWRGFRVREYFNRWNERYASYTHACGRPRVWVHAVSVGEVNAAAPLVNALRAQRPDIRWVITTITPTGSERVRALWGDAVDHVYLPYDVPGSVGRFLEHFRPRLALILETELWPNMLFGCRDRQIPVYILNARLSARSLRGYRVLAPLISRALRTVTCVAAQSQDDAGRFITLGARPDQVVALGNLKFDIAAPAQLQDLVAQFRRQVPATRPVWIAASTHEGEEAAVADIHAQLLKQFPDLLLLWAPRHPERFPKVEALARDRGWTVTTRKAQQWPQARDQVFVVDTLGELMSFYACAQVAFVGGSLQPIGGHNLLEPAAVGTPAVTGPHLHNFSEISRRMREADAVTICEDAACVQRDLARLLGDPAQREAMAAAGLALVANGKGAVARTLVQIAPHLPPLASEIASSQ
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MASDVDVMGKDDISNASHLASVWAKCKDSKSLKKAIFSFLADAVPEIFKANEVQPEEEEEFARKVVLILEWYLFGPNPDQVRSELKASECPPQLCGHVFKNGEPTYSCRDCAMDPTCVLCIDCFQKSAHKSHRYKMNTSGGGGYCDCGDEEAWKQEPFCELHSRAATHVQQDPLDNLPQEMKARAVMLFRMLLRHCYRILFLDEPKDIPDDLQGSNSIPDVYCTMLFNDEVHTYEQVISSLKKAVECSRKAALQFATIVDKDGRSAVRRGNERDCERAKNVIERSTSRLNSTPLKVLVMNMVVVAHQTCALKLLNWLSTVAGGSDAMRVLLCQELLSIKEEGQVTAVIEESMLNDTHLWKVARAQWHQLFMSTLLMDSEHKKQFAVLFTKHYPTILVDYSTIDDHDHALSISSLSVQIFTVPTVSRMLVEEHNLLFVILRSFVDQTIQFRDGRGHLQFRRNPPPSIRRALYGLLDLRYVLSNKPESWTGDLRDRVMEGVTVLVELLSSMHCMDSVLRQVGHHIEYEPEWEMAISMQMKLGPCLTLLLEWCASDRSLLIKAYRATMAALRKLSRDQQRENVEIEDKTYSCIKYSVSSMTVSIHYALVRFLAGLHLHLGQYELGFYTEGLMNGPSLLPEELIEDPLRTQVLIAQVHAGMWRRNGYSLLNQIYYYQNVKCQTEMYDKDVIMLQIGGSLMEPNDFMASLVTRFDLVRCWTRDFEESKSPEDCSAHLPIITEEFLGLLIVLFCERYVKGVGNVSDEARVRREVLHQLCISPMAHSELTRALPEDHCHETGMESVIHDIADFKKPAGGVGKGMYELKASCLDEYSPYFYHYSKVDQTKSEEQIRQRRKQEDKPQLILPYAMPALMPSFQPLLRILYSDTFMFIIKTLLVRIRKPKGIHLTDNIVHRTLYLVGVALIEAEASHKEGNPMSFIIKGAQGSPNMFEALQSLVGHQRIESNKDFLEWLIKKYEAMLKLAGHTTSTQMKPPPAPAARSAEELDKEAEEKRNRQEMARKRREHLMKQMSAMQKNFIRENPEFFDATNEGGSPRHRTASTCSMETGDVPAHDYPCCLGPRHSPSVMAESSTATCILCQEEEDITFDGKAMVLAAFIQRSTVLSKARQKTIEDGEKFDPLFASSDLYWGTNVSTCGHIMHSTCWQGFFESLLAKEQRRNLRMRGILNYDISQHQFLCPLCETLSNTVIPLLPSVVGLQNATQEGAPVERKSGETAVNLQEWLEGIQKTLQASAQQKEFEKEQEEAGVVPMEAGANSAAASDEEDIEEKEEGEEEMAGEMELGAMGGEEGGAQGGGGLAEGGDGIGAKEMEEEGKVEGATAMPGAMEGGEIGVGSKYMSFIQISTIPSLKRLLAETVSQKFQQLFQFIQVSCLPISENVKEMIRHFSRSAYTVGLGVMPHDDDSRMAILAWNTCAYTVQVTETQLRNEGKALFGALSQRQMDCLRCLIRYSVVNSCLCNYAHVQRHAIRLLSALYPQESSGRPSDPCILDMDVFTLLVSVCMSLPRLYNSNERVAMSLLGGPISDHHLLRVALAAHLVQVLLTASRDIPFEESMEEEGSSVDDSKEGRDLLQACSMLKQYAGLEAAPLPPGWQLVNHVQVSCLPFLRSAALFFHFLTSVPCPAELQNAGIDEFEPLCRYLGLPTNLATLLDCSASPIMEDMIKRWCSHPSIRIKMTEHNPALVRYPIEINQLIDLPRDYSDLMNDRSLFACPRGNSTTQSDSRAPAMCLVCGTVVCSQSYCCQREINGESVGACTAHAIMCGAGSGVFLRVRECNLLLMSGKSQGCSYTPPYLDEYGEPDPGLRRGNPLHLSKECYSELHKLWLSHGIQATVSRKLEGASPLINWQNM
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MPFNYADYVKQPALIGDEWPPNGNCGNWSANNNSLTDWDKCCETASKVPTHLTGNFDTSSLKMLTAKQPSEKISPDAGYVSPNEVCFFTYLSRHNYMFLQEDRKSSEHTNSYDVSASQSPSNDGASSVNTDEHIDVECMTTIEEMDTDEKDEDTIVPEEGSVEVKKEEAESEQPKDQPEPEANIPQTSGTILTPIMQTFLQTPLAAPIPMTPETQILLGLGAKEFQDVMSAAERIRKPVSDSFGFMRSGSSAFSNIEPKELLLRSPSSTNINNNCSSTNNNNEDAAAPAVSSPSTPTTTSASFCRPPGLGPVALPPTPNGQVPMLVCPICGFMCPSKFHFNSHMNTHGDHQCSMCDYTSRTEGRLKKHMRESHTVEEQLKAGLELEPAKETSSNTSSSPKGSISSKDSSAASPINESFNLSTTLASILDSTSNAIAATASSTTEPPSALSALTLDMTSTPSLLSTLGQSNFGTSALDHIKAISENPNFMPEGGMNLASALGVVSQVIKGEPASPEKQSNGESRRSSSGKIKIFKCKQCGHQSLSKDDQWAHARSHIPAEKQLNCQHCNFVTEYKHHLEYHYRNHIGSKPFQCKKCSYNCVNKSMLNSHMKSHTNHYQFRCMDCTYATKYCHSLKLHLKKYNHRRVPEGIEMNGGDSSPTLSQSDATITFSPIVKQEIKSEPIEQTPSIAQPFQFNSLIAGPSFTFGNQMLLNKHLDNGLIRVAGLPSVPMQTFKCPLCEFVAGTQEEQIRHSMSHILSSNQVPTTIASLYNTLNLPTLGNVRDEDEENMECDVKIEDDNTTEDSHCGDEEMEHSSDSAVSPTGSSQVSSVDDDVKCKTSEQNNAHSSHSPISSNDSALDRDGESADDAAPHSPSDTTSVASPPHVPVPIAAPIPISLRPDQAMFQNFLTQAALALNMVNRNMLQCEHCNIPFNNQEAYNTHMMHHTPGNPFKCGKCQYQCHDTLSFALHMYQAKHQ
The following text describes a protein:
Function:
Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.
Sequence:
MIWVNGVLQASIAPTDRGLAYGDGLFATMRSSKRGILFFQQHQARLETGAARLGFDWQMSPALAEQLDTLAAQYPQHCIKLMVTRGVGGRGYAPPEQVNVTEVVSVHPIPAHYAAWQQQGIRLKTSAVQLGHQPLLAGIKHLNRLEQVLIKSLPLPQGYDDWLVLDCMGKVIESSMANIFFIKDNQVVTPSLEHCGVAGVMREQVMLALLALQMDIDCLPFGAERLVEFDSAFITNSVLGVVDVLAIDSHSFKPSPLTADLRQTLSLSL
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MNIDNINLGYFQGDHSSTCSYCHKGKSYSQGFSTNKLYPSTYQSMMDRGWRRCGTYYYKYNFAQNCCLSYTIRANALLSQQKKGQRKIAKTFLKVVQSDLLKNKVESLKPAIQQISKNLKQQQEQKQLNKQPQQLKQKVEPKQKIVVEEKQKPHKVSEEIVQSLKLQFQQFQELIAQNIPEVIQLFKEYFDSKGFKIDEVQSIFQVNLNIDTVQIFPSKVNSKGDYYSNFMMLIYGLNKKLLFQDFPVNKFALLIIPFVQKYFISNQFLFVQEPTGFLSVFTKENQQKADVHLMQIEKQLVQEKQKIIIEQNLVNQQKQNIKLIDTETFKSNQFQIGNMKVLLKPAECTEENFKLYQSYCKEIHGSTKESKDGYSSFLCEQGLDQKKFIQSQIDKSKILFMGCFHMRYYLGDVLVAIGVVDITETAMSSVYFFYDPIFEEFNFGTFGALVEIEYVKLMNQHFPDFKYYYLGFYLQNTNKMSYKGDFEPCELLCPETYTWVELTKELRAEIDRRQALAVNQRQLRISKQNVGVIDDMKINDKSFYGSVQVSMKGKVMKLSALNFNMNKLNNYLDNAYSRFGRQLMEKLIFEL
The following text describes a protein:
Function:
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), an effector of the Ras/cAMP pathway. Inhibits PKA activity in the absence of cAMP. cAMP activates PKA and promotes growth and proliferation in response to good nutrient conditions. Together with ZDS1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated. Nuclear when not phosphorylated.
Domain:
The inhibitor sequence (IS) is a substrate recognition motif that docks to the active site cleft of the catalytic subunit rendering the holoenzyme inactive; Binding of cAMP to the 2 tandem cyclic-nucleotide binding domains (CNB-A and CNB-B) induces a conformational change in BCY1, causing the interaction surface with the catalytic subunit to be destroyed and eventually the dissociation of the R dimer from the C subunits.
Sequence:
MVSSLPKESQAELQLFQNEINAANPSDFLQFSANYFNKRLEQQRAFLKAREPEFKAKNIVLFPEPEESFSRPQSAQSQSRSRSSVMFKSPFVNEDPHSNVFKSGFNLDPHEQDTHQQAQEEQQHTREKTSTPPLPMHFNAQRRTSVSGETLQPNNFDDWTPDHYKEKSEQQLQRLEKSIRNNFLFNKLDSDSKRLVINCLEEKSVPKGATIIKQGDQGDYFYVVEKGTVDFYVNDNKVNSSGPGSSFGELALMYNSPRAATVVATSDCLLWALDRLTFRKILLGSSFKKRLMYDDLLKSMPVLKSLTTYDRAKLADALDTKIYQPGETIIREGDQGENFYLIEYGAVDVSKKGQGVINKLKDHDYFGEVALLNDLPRQATVTATKRTKVATLGKSGFQRLLGPAVDVLKLNDPTRH
The following text describes a protein:
Function:
Putative antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC10.
Sequence:
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQVWRATS
The following text describes a protein:
Function:
Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MAWPRFLQRGTLLTSFSHHHVAVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPDAFNTSIDLPAEIWSSNHLFPSTEDATLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGLPSIEAEAGSEEDSQRPLINGAENEDDYEPNYSIQEDRAVIQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLQGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSVNALLMTITGFFIGGPSNMVSSAISADLGRQELIQGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFISPLIVREVFSLVQRRQAPILNE
The following text describes a protein:
Function:
Involved in actin localization and thus in polarized cell growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MGSVNNEEKTLIEPQRLLRKNTWHPEVDDSEVPPSVFPEYPVHKAIQKTSDSFRKRNYSAGDYVIAPLGGEREGSSLTHSWTFQPGKHNQRLYSDNFQEAQRQWKRLQEWGEVKETKKIRKRFDRFSGRKYINHYEIIKELGRGMHGKVKLGRDTVTRELLAIKIIPKTERRPKLGRANASSQKEKVRREIAILKKCVHPNVVRLREVIDDPSSTKVYLVLEYMSGGEVPWTDCDSPVLSISEARQYFRDVVLGLEYLHYQGIIHRDIKPANLLLNSSNCVKISDFGVSYIANAGLNEDNDVELAKTVGTPAFFAPELCWTDLDRPRPKISEAIDVWALGVTLFCLLFGRCPFNASMEYELFDKIVNERLNIPSTPDIGEEGRDLLKRLLCKDPEQRITLVEVKLHPWTLDGLKDPEKWLQNTDPSTVSRVEVSTDEVASAISLVGRLRRKLGKLFRFRRPKARVFDSSSSVPSDSSICRPESSGNSSIGLSASELSDSFNRLAVNESQKDRERKQVHPVEMGRNSSEKKPRCDFGWDYEAFPNDNQDADDACSYNTGDSIPQVSKSINGHFETYSRTSMDTDDVASFESPNAKHEESGMPVVTFRNYENYDANPSNFHPVVPGFVSSPNLHLAGGSDTPIYCIEHSFTPTN
The following text describes a protein:
Function:
Putative receptor for purines coupled to G-proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNSTSSFNNKFVSYQQDLCHPELSFFAISSLQRNKTANRDKAPGDYKSTAYLDEYTEIFKMYSNSTSNVETDCSATNVTFQNSLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFPKALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARNWKRRYDVGISAAIWIIVGTACLPFPLVRSTYLGNKTESCFADLGYKKMNVVALVGMITVAELAGFVVPVVIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPIVQSTLYFHPFCLCLASICCLLDPILYYFMASEFRDQISRHGSSVTRSRLMSRESGSSMIS
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence:
MAPKAEKKPAEKKPAEEKAEKKPRAEKRVPSKEGGEKKGKKKAKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAAEAAKLARYNKKPTITSREIQTSKLSRKLVQISVGLVFLPFQLFLCIADVVGKHLGKERLPYNPNKSHAGSIAIAGFLASVGQNLY
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MASAGGERLSSSDFKKKQEIEEARKNGTLPPEQDADGNLINPHNPEFISKRPWYLGDSGPSLKHQTLQHQAHLLSIQEADELYIKGRKQLTTTARQRKWRKGACKNCGAMSHKTNECVERPRKVGAWKTNKDLQSDEVVVDVRSEKFGKLAFDAKRDQWLGYDPKEHAKTIERYEKVDEARKNKRAEEINQKLKESADKKKKPRGKAKDRGEGNSGSDSDSDYESDMESEDEEFRDHDEGPMFTDRVARQGGVGGAQMKTTVRNLRIREDTAKYLRNLNPNSAYYDPKTRSMRDNPNPELNPEDTTFVGDNTARFTGDAQKLASAQLFAWEAYSKGTDIHPLANPSQAEFLKKQYEERKAALEKEKSRKILDKYGGQEHLEAPPKELLLAQSEHYVEYSRDGRVVKGRERAPVRSKYVEDSFENNHTSIWGSWFDRSEMAWGYGCCHSKVRKSYCTGDDGKKALEEAKSANAERPMLKAPEKLEPGQTDTQAGGVISKRSEMYGENIAPELDEKKLKKAIKKAAKEKKKQAEQDDKKRKYNSMGNYEVNAEQMEAYKLLKSRGEDPMAKVLGNDVLLEEDEEGKGKRARR
The following text describes a protein:
Function:
Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MVQHCEALNRSVQVVNLDPAAEHFNYSVMADIRELIEVDDVMEDDSLRFGPNGGLVFCMEYFANNFDWLENCLGHVEDDYILFDCPGQIELYTHLPVMKQLVQQLEQWEFRVCGVFLVDSQFMVESFKFISGILAALSAMISLEIPQVNIMTKMDLLSKKAKKEIEKFLDPDMYSLLDDSASDLRSKKFKKLTKAICGLIDDYSMVRFLPYDQSDEESMNIVLQHIDFAIQYGEDLEFKEPKEHEDESSSMFDEYFQGHQNE
The following text describes a protein:
Function:
Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Also involved in controlling locomotion and head movements. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling.
Subcellular Localization:
Cytoplasm. Cell projection, axon. Perikaryon.
Sequence:
MVYGLGEALKNLNSYCQERTTRIRNSLSPSRPSMSEATATGSSSSSRASTTIPSTPNMDVTPTVEDPRQNDNNASGMTRDEFRQYGKETVDYIVDYLENIQKRRVVPAIEPGYLKDLIPSEAPNTPESFESVMEDFEKLIMPGITHWQHPRFHAYFPAGNSFPSIIADMLSDAIGCVGFSWAACPAMTELELIMLDWFGKMIGLPAEFLPLTENGKGGGVIQSSASECNFVTLLAARFEVMKELRQRFPFVEEGLLLSKLIAYCSKEAHSSVEKACMIGMVKLRILETDSKFRLRGDTLRNAIQEDRNLGLIPFFVSTTLGTTSCCSFDVLSEIGPICKENELWLHVDAAYSGSAFICPEFRPLMNGIEYAMSFNTNPNKWLLINFDCSTMWVRDRFKLTQALVVDPLYLQHSWMDKSIDYRHWGIPLSRRFRSLKLWFVIRMYGIDGLQKYIREHVRLAKKMETLLRADAKFEIVNEVIMGLVCFRMKGDDELNQTLLTRLNASGRIHMVPASLGDRFVIRFCVCAENATDKDIEVAYEIIAQATQHVLHDSVKAVIAEEDEEAVALEEMVADLNITETPEKCLTRQNSANAAESGQKLERQLSKEEILAQKQHESLAKKRSFLVRMVSDPKCYNPKIVRHLNMANHRKMSQDLYRDRTLMQTISHSQRPNRLSQSPGSAGSAFFDDDDDRIVADVQTGLQTPI
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport. It can also use D-mannitol.
Subcellular Localization:
Cytoplasm.
Domain:
The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Sequence:
MTVIYQTTITRIGASAIDALSDQMLITFREGAPADLEEYCFIHCHGELKGALHPGLQFSLGQHRYPVTAVGSVAEDNLRELGHVTLRFDGLNEAEFPGTVHVAGPVPDDIAPGSVLKFESVKE
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm. Nucleus. Note=Localizes to the A-tubules of DMTs (By similarity). Located in the cytoplasm of spermatocytes and the nuclei of round spermatids and elongated spermatids.
Sequence:
MESPKTFMRKLPITPGYCGFIPWLSCQESSSEDRMNPCVKAFQERTQRYKEDQQGLNCSVANTPPLKPICSEDTVLWVLHEYAKKYHPLTLECKNEKKPLQEPPIPGWAGYLPRARVTEFGYATRYTIMAKKCYKDFLDLVEQAKRAQLKPYEQTYDVRAAQPLSPSSKILQLQGLSPAFPEFSGPGQTPPSEDPQAPRPCGCAQWSSQSCSRNVYGEPPSLAKAFAES
The following text describes a protein:
Function:
Catalyzes the decarboxylation of L-tyrosine to produce tyramine. Plays a role in acid resistance since tyramine production via tyrosine decarboxylation appears to provide a cytosolic pH maintenance mechanism that helps the bacterium cope with acid stress such as that encountered in gastrointestinal tract (GIT) environments. Therefore, may contribute to the colonization of the human GIT by E.faecium (By similarity); Also involved in drug metabolism, being able to catalyze decarboxylation of levodopa (L-dopa) to dopamine. In gut microbiota this enzyme is in fact exclusively responsible for the decarboxylation of levodopa, and thus reduces in situ levels of levodopa in the treatment of Parkinson's disease. It was shown that abundance of bacterial tyrosine decarboxylase in the proximal small intestine - the primary site of levodopa absorption - contributes to interindividual variation in drug efficacy and can explain the requirement for an increased dosage regimen of levodopa treatment in Parkinson's disease patients.
Sequence:
MKDMDIKAVFIGDKAENGPVYKMLLNKMVDEHLGWRENYIPSDMPAISEGDKLTPDYLATRDHMIEVLDEVSQRLRAGSIPWHSAGRYWGQMNAETLMPALLAYNYAMLWNPNNVALESSMATSQMEAEVGQDFASLFNMADGWGHIAADGSIANLEGLWYARCIKSIPLAVKEVLPEKVKNMSEWALLNLSVEEILEMTESFTDEEMDEVKAASSRSGKNIQKLGKWLVPQTKHYSWMKALDICGVGLDQMVAIPVQEDYRMDINALEKTIRELADQKIPILGVVAVVGTTEEGQVDSVDKIIQLREKLKDEGIYFYLHVDAAYGGYARSLFLNEAGEFVPYASLAEFFEEHHVFHHYVTIDKEVYEGFRAISEADSVTIDPHKMGYVPYAAGGIVIKHKNMRNIISYFAPYVFEKSVKAPDMLGAYILEGSKAGATAAAVWTAHRVLPLNVTGYGQLIGASIEAAQRFREFLEQLHFTVKGKTIEVYPLNHPDFNMVNWVFKVQDCTDLNAINELNEKMFDRSSYMDGDVYGERFITSHTTFTQEDYGDSPIRFIERMGLSKEEWQKEQQITLLRAAIMTPYLNDDRIFNFYTKEIAKAMEKKLNEIIK
The following text describes a protein:
Function:
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Sequence:
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSVTRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRSWQDSSVSYAAGALTVH
The following text describes a protein:
Function:
Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR. In turn, WalR binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell septum.
Sequence:
MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLLSEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKVIGNIYIESKINDVYNQLNNINQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAKEDIIGYYMLSVLSLEDEFKLEEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGAWKDEELAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKKTIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIEDGDWDE
The following text describes a protein:
Function:
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme mus-8/ubc2 to form the mus-8/ubc2-uvs-2/rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDVFGDEAFNVPDSTDWLGTPLACLMPVEQAFRCHVCKDFYDSPMLTSCNHTFCSLCIRRCLSVDSKCPLCRATDQESKLRGNWALREAVEAFKNSRKVLLEFARTPPTIQAILPDQAGPSSPSKRKATEMEGPKEEDPESKRPRRSTRSTRARAAELTAAILQEEQDTTPSADPDYVDQPPDDGLVACPICLTRMKEQQVDRHLDTSCPGSPQAASKRRPIPAQTPQPSTFPSFNTRLTSQTNQKPPERLPALAYSMLRDTALRKKLSELGLSTHGSRQLLEKRHKEWITLWNANCDSSRPKKRSELLRDLDEWERTVGNPGTAAGGGGGQQGLGLMARAQATGAQIKDKEFDGKAWATRYGGSFGDLIKQARQGIKRQTLDGNGEKADTKGGGGGEDVGPAELPTLQAREGESSAAPTRMDIVPPSSPPRPGQVDDADTEHDGQAPGKDAIAEDTAMREQVIPGTPDKERQWETSQQQQPPIPGDAQLSGMKKPNPETC
The following text describes a protein:
Function:
Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity not exhibited with NAD. The alpha and delta subunits form the hydrogenase component that catalyzes the reduction of protons to evolve hydrogen.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNLYLPITIDHIARVEGKGGVEIIIGDDGVKEVKLNIIEGPRFFEAITIGKKLEEALAIYPRICSFCSAAHKLTALEAAEKAVGFVPREEIQALREVLYIGDMIESHALHLYLLVLPDYRGYSSPLKMVNEYKREIEIALKLKNLGTWMMDILGSRAIHQENAVLGGFGKLPEKSVLEKMKAELREALPLAEYTFELFAKLEQYSEVEGPITHLAVKPRGDAYGIYGDYIKASDGEEFPSEKYRDYIKEFVVEHSFAKHSHYKGRPFMVGAISRVINNADLLYGKAKELYEANKDLLKGTNPFANNLAQALEIVYFIERAIDLLDEALAKWPIKPRDEVEIKDGFGVSTTEAPRGILVYALKVENGRVSYADIITPTAFNLAMMEEHVRMMAEKHYNDDPERLKILAEMVVRAYDPCISCSVHVVRL
The following text describes a protein:
Function:
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Positive regulator of the Wnt signaling pathway which acts downstream of wnt1 indicative for non-canonical Wnt signaling. Also negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. Required for convergent extension movements in gastrulation.
Subcellular Localization:
Cytoplasm. Late endosome. Nucleus. Cell membrane. Note=Predominantly cytoplasmic. Also found in late endosomes, the nucleus and at the cell membrane.
Domain:
The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Sequence:
MLGRKIPGSGVLGAGAGMDRGRTGERLHAALAGLQELHFLRDKQSAMVHWALTLNRDQPDPSKQENVSKEELRLEATLSLLKQQLTRLRRQDVGLKTHLQQLDQQITELKLDVCKASTEHLESDSRPSSGFYELSDGGSGSLSNSCTSVYSESLSSSSQTSLLPLLSTSYASHGRSSCGQTGVSRRCSADESTAQSDAPRSGVKLGSSLIRTATARADRARQRPVSTGDLDRMIGPGFGAFKSTDVKSSTPCSSPQNPSVDPKYQSNLVSSNGTEVYRYPSPLHAVALQSPIFSCTSDQGSSVALDEMPEEETQNLNEESTISSSVGYINKLLQRSSSRVNLLSSIKRIETVSGTHEQIPRSQEMIYGSLNGPQLLGSLQQLSMPLENALETGKTSALNNNQKQMDPPCLGSNFKEVEVQMLHHGKHPESSLDLQKNNFPINNTAGKVGAESDNGASEKRSGHFPKDLSVVQKPVERKSSFTSGREGSRASCHDKSSIPQSEFVHAQFVPAGSQRVKVRQADKKTKSVKLRKKSSEKPSAKKQHQKPLSREFCTKNRTDLKQSGSCRGKVTYLEESQAQSCSDCSCNGLINSHCIQNNHQQIPSSKSTKSRKAPEPVYHPLDHAKKKPSSRKWPSSSEIPLPPTLHTQRSKEMLNSRKVAMVRSVSARPRSGHWGCPPPRALPHSLSTSSYFSYLESRYPAAPVSSRHPPRCESEFSEYSAECASLFHSTIAASSDGEMSDYTTNRFGDSESSQGSQTASESDSSLSLDEEDLLEEEEEDEGGLVWAQAAMGTTAAGFSLQQHHRSESAACRIKASRALKKKIRRFQPASLKVMTLV