lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
Sequence:
MLNNLTDCEDGDGGANPGDGNPKESSPFINSTDSEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYIFPAMAIFKAEDASGEAAALLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDICAKFAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKDVIVEKHGMPSIPLPEATPLNLDQPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLRVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLKHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEESAGDSEEKPEEEVQLIHDQSAPSFPSSSPSPGEEPEGGEAAPEKVHLTWTKDKVVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEAIVKKSQDAKLVLLNMPGPPRNRKGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
The following text describes a protein:
Function:
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Sequence:
MPRFGAHMSISGGVSKSFARGESVGLDSMQIFAKNERQWTAKPISPEEATAFRTEQQRTGIHPVVVHDSYLINLAAPADELREKSIAAFADELERCAQLDIPYLVTHPGAHTGIGEEAGLARVADAICRLLAEGVGGNTMILLETTAGQGTALGYRFEHLARLFELIPYHERLGICVDTCHIFAAGYDIRDPEGYQTTFAELDRLVGLTRVKCFHLNDSQKDLGSRVDRHAHIGQGCIGVEAFRMLVNDPRFADLPMIIETPKGEDMAEDRMNLALLRSLVQGAE
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MADPSSFLAKLVAPRYRHEILEIANSSVDLGDKHVILKKNKTNAGKLTQKKLSRREIKELGLYTLPHDTITYRDGLKLHRMWLGYYDTFFPPGECPDVTEARYSTIVASLLKADYHGAKIHIVRSKQPSVVGMKGIVVLDTKGTFKMISKDNKLRTIPKNDSQFEVFLQDKVITIFGKHLNARPAERSVKKMKTFAFPDL
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MVVLGSTGSIGKNALKIAKKFGIEIEALSCGKNIALINEQIQVFKPKKVAILDPSDLNDLEPLGAEVFVGLEGIDAMIEECTSNLVLNAIVGVAGLKASFKSLQRNKKLALANKESLVSAGHLLDISQITPIDSEHFGLWALLQNKTLKPKSLIISASGGAFRDTPLEFIPIQNAQNALKHPNWSMGSKITIDSASMVNKLFEILETYWLFGASLKIDALIERSSIVHALVEFEDNSIIAHLASADMQLPISYAIDPKLASLSASIKPLDLYALSAIKFEPISMERYTLWCYKDLLLENPKLGVVLNASNEVAMEKFLNKEIAFGGLIQTISQALESYDKMPFKLSSLEEVLELDKEVRERFKNVAGV
The following text describes a protein:
Function:
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Sequence:
MTSSSASGRKTLSKIACNRLQKELLEWQVNPPAGFKHKVTDNLQRWVIEVNGAPGTLYSNETYQLQVDFPEHYPMEAPQVIFIPPAPLHPHIYSNGHICLDILYDSWSPAMTVSSICISILSMLSSSTMKQRPEDNDRYVKNCRNGRSPKETRWWFHDDKV
The following text describes a protein:
Function:
Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.
Subcellular Localization:
Nucleus.
Sequence:
MERFGIPRGKRPRVQVSLDDKERAIARIRGGETKAGISRELGVPESTVRGWVKRAEQRLARETTSQTGSANYSTILAMTLAKPQVTISTKSSASSVISKSSYSSPPLDLKPLKQPQKRNINGHPVTCTQDPVEDSAATSIPIPVPIPVPLPVPPMVSPDSEQQMSAWLHIFNAGILNFTLIASAAVLQARSRGLADRLPLWQIITDFVDEAERNVNANGGWYLEGQPATGHMSARQRPVRVPTKVHSYRRNLKAPPAHITAEDDEDSYTDADVPH
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKTSTKQRSEHPLVLLWLIVYNVASFVGWAYILTLVLHCLITSNGDYSLSYSVVSYTLELVQLCALLEVLHALVGAVKSPVITTALQISSRLFLVGLCYFFNDSRVRQHIAFTTMVLAWSITEVVRYSYYALSLLAINPSALVWARYTFFYVLYPIGAGSELWLLMRSWDSARQYSTLLYYTLVGMAALYPPGFYVMYSHMIKQRRKYLGPKRSKKHA
The following text describes a protein:
Function:
May be involved in an early stage of magnetosome nucleation (Probable). Not essential for formation of magnetosome membrane vesicles, it is probably functionally redundant with other proteins. May bind magnetite (By similarity). One of 7 genes (mamLQBIEMO) able to induce magnetosome membrane biogenesis; coexpression of mamLQRBIEMO in a deletion of the 17 gene mamAB operon restores magnetosome vesicle formation but not magnetite biosynthesis.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Magnetosome membrane; Multi-pass membrane protein. Note=Tagged protein is found in punctate chains.
Sequence:
MPSVIFGLLALAIGLLGLTAWWWSVTEFLRGAVPVALIIFGLVALAAGVQSVRVPPAGKRANSDPNIDG
The following text describes a protein:
Function:
Histone methyltransferase that monomethylates 'Lys-5', 'Lys-8' and 'Lys-12' of histone H4 (H4K5me1, H4K8me1 and H4K12me1, respectively), thereby controlling gene expression and remodeling chromatin structures.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm.
Sequence:
MTDLTAEAAISPSDDILLPALASLREGHPDKGILKLLAQLKIDHPEWAVSEKRFRKALQLAPCPGGGEADPKEKALVADTGLDPSIDVKSIAPKVEVKMFAGGKGKGLVAKEELKQGEMLWQEEPWIVTSDPGHYSLLTQSMMCSQCFSLFARPSPPLSVPCPHCTTAHFCNRLCYTKSLSSSHPPLLCPGLNPDASSLMNFIRKRGERSVEGVAKILARWRGEREWDAKGKAEEMEKRIWKGMARVSQKRKEMERREWSYISKARMEEWHLIHIMLTNVLNPSPTHENYKPFQRLLISQHPRRSKPVPLTEKEVKRWFSFESFLELLGLVGLNQEDSGGLYALHAHMNHSCEPNIQVRNLPKSYTPPTQDTLPVNLPPPIQAGDRVSNKLTILARHEIQPGEELTISYVNMKMSRDERRQALREGYGFWCACDRCMREKEQPNGEKAE
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MALPSRLLYQLLGKELFHQARANSHRSISHPRFPPTLLLTHPSPPSQLTSSCVSGIPSMPEQSTSGSRGYRLEPWRCAVSSPDSQASHSKPPQEPKTLPSVEAESSKPGTSQRKPEQKPKTIPFVDANAVHKAENERRDAVRQEAAPGVAEAKRIIGEEAKKEQARSDRDEILEAALNHVVTLGWSDAALAAGARDIGLSPAAAGVFGRGGVELLEFFIDECNKKLAKTVEEEGSAFSELSTRDKLVQAIKLRLEMQAPYVTTWPQALALQALPQNMAAAVQKRARLVDVLWEVTGDTAVDASWYAKRGLVAAVYGATEVYMLTDFSPGFAETWKFLERRIEEAVELKKSADEFKHLAEAIGAGLGSTFGSTVDRLMQGGDSSKRRR
The following text describes a protein:
Function:
Transcriptional activator that controls bicoid gene expression during oogenesis. Found in transcriptionally active cells. Binds to specific sites on polytene chromosomes of third instar larvae. Binds to the consensus DNA sequence 5'-YTAGAGATGGRAA-3'.
Subcellular Localization:
Nucleus.
Sequence:
MDTCFFCGAVDLSDTGSSSSMRYETLSAKVPSSQKTVSLVLTHLANCIQTQLDLKPGARLCPRCFQELSDYDTIMVNLMTTQKRLTTQLKGALKSEFEVPESGEDILVEEVEIPQSDVETDADAEADALFVELVKDQEESDTEIKREFVDEEEEEDDDDDDEFICEDVDVGDSEALYGKSSDGEDRPTKKRVKQECTTCGKVYNSWYQLQKHISEEHSKQPNHICPICGVIRRDEEYLELHMNLHEGKTEKQCRYCPKSFSRPVNTLRHMRMHWDKKKYQCEKCGLRFSQDNLLYNHRLRHEAEENPIICSICNVSFKSRKTFNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTHEGDVVYGVREEAPADEQQVVEELHVDVDESEAAVTVIMSDNDENSGFCLICNTNFENKKELEHHLQFDHDVVLK
The following text describes a protein:
Function:
[Isoform TIAF1]: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.
Subcellular Localization:
[Isoform TIAF1]: Nucleus.
Sequence:
MSSPSSPFREQSFLCAAGDAGEESRVQVLKNEVRRGSPVLLGWVEQAYADKCVCGPSAPPAPTPPSLSQRVMCNDLFKVNPFQLQQFRADPSTASLLLCPGGLDHKLNLRGKAWG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). Plays a critical role in the regulation of nuclear lamina.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDTESPHLRFSDADGKEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDREASSSPEDRNDRCKKKAAALFDSQAPICPICQVLLRPSELQEHMEQELEQLAQLPSSKNSLLKDAMAPGTPKSLLLSASIKREGESPTASPHSSATDDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQREGSCMAEDDAVDIEHENNNRFEEYGWCGQKRIRATTLLEGGFRGSGFIMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPEFSKWANDEMPSTSNGESSKQEAMQKTCKNSDIEKITEDSAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITAPGDLRRIYL
The following text describes a protein:
Function:
Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Late endosome membrane. Membrane; Multi-pass membrane protein.
Sequence:
MACCGGSVCCCCGNRESRTPEELTILGETHEEDEEILPRKDYESLDYDRCISDPYLEVLESINYKRAWRYEAVRWIMVFAIGVCTGLVGLFVDFFVQLFSRFKYRVVQGSVEECTERGCLALSLLELLGFNLTFTFIATLFVLIQPVAAGSGIPEIKCYLNGVKVPGVVRLRTLVCKALGVLFGVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISFQKIRFDFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFSSWGSFQLPGLLNFGEFKCPDADKKCHLWTVVDLAFFIIMGVTGGLLGATFNCLNKRLAKYRMKNVHPKPKLVRVFESLLISLVTTVIVFVASMVLGECRELSPSNWSNTSLTVQVSSSEEVNSSIKTFFCPNNTYNDMATLFFNPQESAILQLFHQDGTFSPVTLSFFCCMYFLLSCWTYGISVPSGLFVPSLLCGAAYGRLVANLLKSYLGFSHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEISYGLPIMITLMVAKWTGDFFNKGIYDIHVELRGVPLLEWETEEEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTAHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKASILTRAGEQRKRSQSMKSYPSSELRNMCDEHIATEEPVEKEDMLQQMLERRYTPYPNLYPDQSPSEEWTMEERFRPLTFHGLILRSQLVTLLVRGVCYAENQSSANQPRLSHAEMCEDYPRYPDIHDVNLTLLNPRMIVDVTPYMNVCPFNVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTHEFLQARLRQHYMTS
The following text describes a protein:
Function:
Connects the two COX monomers into the physiological dimeric form.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MLDVEAQEPPKGKWSTPPFDPRFPNQNQTRNCYQNFLDYHRCLKIRTRRGKSTQPCEYYYRVYHSLCPTSWVSRQRGRRARRGEGSAEAEPASRSLPFCFPGGELE
The following text describes a protein:
Function:
Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP. Affects virulence of this bacterium when there is a complete loss of phosphatidylcholine formation due to absence of both the synthase (pcs) and the methylation (pmtA) pathways. Reduced virulence results from lowered yields of bacteria within host macrophages and because of loss of high multiplicity cytotoxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNPIKPPFTLNQYFAAWFVHVFTASAACIGVFSLYKIYQHDYVFALWLMAITVFIDAVDGSLARLVHVKSVLPKIDGALLDNIVDYLNYVITPCFFLLVKPGMLPADYVVPITAAITITSAYQFCQDDAKTPDHFFKGFPCYWNITVFYMYIFNTSMIVNTVLLSLFCVLIFIPVKYVYPSRLDYLTESRVLKILMHCCSALYGISSFCLLVNYPETNKLWVSLSLGYVGMYLFLSFYRTYYPMFKAKITANNKD
The following text describes a protein:
Function:
Probable RNA-binding protein that may play a role in growth regulation.
Sequence:
MDRSSDHFNPPGLAVPAASKSRQMAANNNPWRGPLPPLLNARAGFGDTSLFSSSLPVLSHEKLIFSDSAHGTPSMDDTSAKMKLLADDPDEKDYKFDFDLRQIDDLLPDEDEFFAGITDETEPVGQTNTTEELEEFDVFGNGGGMELDIDPVESITVGFANSSIVDGARGNGINPFGVPSTVGTVAGEHPFGEHPSRTLFVRNINSNVEDSELRSLFEQYGDIRTLYTATKHRGFVMISYFDIRAARNAMRALQNKPLRRRKLDIHFSIPKENPSDKDLNQGTLVIFNLDPSVSNEEVRQIFGAYGEVKEIRETPNKKHHKFIEFYDVRAAEAALRSLNKSEIAGKRIKLEPSRPGGTRRNFMQQLGHDLDQEEPRSYRHSHVGSPVANSPPGAWAYSSPTDNNMLQAFTRSPTGNGMSPIGMPSLISNAPKIAPIGKDSNWSKYDQVFSNGNQSQGAAFQHSHSYQDHNSEYMSSSPGTLSGPQFLWGSPKPYSEHSKSPIWRPPAIGPALSSSSRTQGQGFLYSSRQASLFGSSDQHHHHVGSAPSGAPFESHFGFLPESPETSFMKQVRFGNMGNVGTGRNGGALMLGMAGRASVNPGSSLIGSLTDNSSTNFRPILSPRLGQAFYTNPPYHGPGTFGLDNSIDRARNRRVDSSVLQADSKRQYQLDLEKIRRSDDTRTTLMIKNIPNKYTSKMLLAAIDEFHKGTYDFFYLPIDFKNKCNVGYAFINMISPVHIISFYQAFNGKKWEKFNSEKVASLAYARIQGRSALISHFQNSSLMNEDKRCRPILFNPNGQDSVNQEAFPINGICIHMPLEDDCLDNEEDKNQNEKTGESSTDIGGSL
The following text describes a protein:
Function:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Mainly localizes in the nucleus.
Sequence:
MWDGQSEMCQAHVLFDSFVQAATCKETLRAFQDLCEELNLNPGGQPQFYHTLRSRLHYWKAKALWAKLDKRACQKEYMRGHACTSTTCLIIGAGPCGLRTAIELGFLGARVVLVEKRDAFSRNNVLHLWPFTIQDLRGLGAKKFYGKFCAGAIDHISIRQLQLMLLKVALLLGVEVHVNVEFKHLLEPPENQEKRVGWRAEVQPSSHPVRQLEFDVVIGADGRRNTLPGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQRFFQDLRQATGIDLENIVYYKDDTHYFVMTAKKQSLLEKGVILRDYADTEMLLSRHNVDQNALLSYAREAADFSTNHQLPALDFAINHYGQSDVAMFDFTCMYASENAAMVRQRMGHPLLVALVGDSLLEPFWPMGTGIARGFLAAMDTAWMVRSWGQGNTPLEVLAERESVYRLLPQTTPENVSKNYSQFSVDPASRYPNINMQLINAAQVRHLIDTGEGPVLGLDAVSSPHPRLTRQESMARYSKLLSWCQEHTHGYRKVCVTDFTSSWRSGLALCALIHTFRPDLIDFASLEESEAEFSGQLGLDVAEQEFGICPIMTGKEMSVLEESDSLCMVMYLSQLHELLKDTSPPSGSQSSEERAVLFSSSRSPISLLSKLGQSLSRKRNPKDKKEKEADSVGKRRRTSQAGQSEEEDALHDGNENKSPAETPGSEPKASEGHSKVRSMASLLLAKFEENSPSPSTTAIRRQNYIHMYTGGVSSLALQIANQIQSQQAQAPKLLHRRESGSQKDLPVNVGSSDVCYFCGRRVYVMERLSAEGKFFHRSCFQCDHCSSTIRLSNYTYDQLHGKFYCKHHFSFRLASVAQRKRPAPPVAPRPAQASLAASSASTSLSSLGSVGTATPDSWSSSTHTDMASSLAKRLCGTPERIELENYKPSPQKQDSPLQEVPEETLAQHNLSASLQEKNAEEQSSSSESDLEEEELVWKKGEELHARTNGERKLDLEEELKEEEGGEKLEKQEGEEEGEVSEEEQDEGDSSDESYEGCSDDPDIDVSSLSESKLCDQREQEESVPFHQSPASTESPVSMKPSESDLTPDPSTTPESSPAKRSEVVEEFWMKSAEIRKSLGLTPLSRELQPKHIAASTQTSNVKESFYTSVTYNTAALDSPNQSARICDSSTQTHSVTDLQETSPLGPTDGDAGVDLGRCSVVHRLSITVEGCVMADNQGLDSTSFATESVLNPDAGLPTPPYSPSHSPLVGKQCRALHHSEPILDREVMAFSSTCTASVPQRSSFKSDLEQAQSLPPDEIEILCGDEAEKLPERSCRMESGEVDNRRAEHSRTLPDRVVAPLLAGGPEVRLRRSEMKLWGPDADGDVKEKKRSSLFSPRKSRKNGNAAAESGRETGKHKSLWKTVFSVYKKDKKRKEVAVVAETLPAANNGSKRKVSGINRTTDLCFRKNPSFSEDTDMSCHALLERCPLRAQRAGTEEELNARLTRRVQRAARRQAKQEELRRLHRAQIIQRQLEQVEVKQRQLEEKGVAVEKALRGEADFWEDSSTSVLLDVHLCGMGKKDDPSLMHQWFKLVQEKNALVRYESELMIFARELELEDRQSRLQQELRERMAVDDHLKGEEELAEERRILSEMLDVVEQRDALVALLEEQRVREKEEDSDLEAVMLSKGFSLHWD
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSALQTFMLVVDHDKVEAKQIAERVAQDVEYKRTTLIEVVQSLGEYINDEDPILRGKAVSYLTAVIRALPPKYLSRQQIQVLTTFFCDRIEDGGAVTGLDTLQKLDRFNDTLAEEVAQAIFERLQDLQSRSQSQRFQVYQLLNELMSNHRAALHKMGDTSLVGIVDLMTGEKDPRNLMLVFSILKVVMIEWDISNHAETLFEAVYNYFPITFRPPPNDPYGITAQDLKDRLQDCISSTSLFAPYAVPALLDKMDSTSPNVKKDALNALTACIRSYDPDTVSKYSIQIWDVLKFEILNAQEEFLSELSLQALNSIAKRLSEGIAAISEQSPLAQFLRPITKECNEQLREPQQKQAKPAQQILNSTSSASTASFTVIVQAVVAPLLTVYQEADGLAKQRAILETLGGLFDSAIEVFGKWDSPELEPAAENALVEFKDQFSDVFGQALMGAAKEEVSFRVTALEGFLRLSILRDYFQDNEIGLFVQYLDEILLKEECAGRGDLKKKAIAALAEISKHKPRLIMDITFPAFVATLPDSDEGPNTDYITTLENLAQISVERDIFETLVRRLLSKLTILLQKERAGSIAYPRAILMTILYVMKQRNLDKDPNLELYYDKIVRGLCRGVADAATGKSTNRILNDAVVIDILGRLCNVIVRCLSKQKQDEVAQNVYTLFASSSTFTPVPFSQAANEDQQRTMIISTYLLAGLPADCAHLPYSGRDLAPLLSDLVTRSLTECEPPTHLAFLRHSALLVNKFLPRPELSVATNILNKLFSAGAEEKKVPSGTIKTIFWLSKALIIRLAPTTTEILTSLLSLLSSHDELTSTTAARGFAILLKDDDVLSADNGANIRLLAKQRVFTTLTPLISNRIREVNVAGDDSSTPAHIKPAHLTALSGILSTISPSLVMPELPTLLPLLLQSLDLQNADSQGVRAATLETLAVIIRENGVGIIEECGHVQSLVTRLLKTAAYNPTPSGSDQQAAGAGPVNGPRLRVEALRCLNLLAQTPKTDAPAVAKAGKLSPLLPVKSQVVRSLRMILDDPKRDVRKAAVDARGAWLRNVDDAPDEED
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MFFSKLKYFIQLFSLIFSLISNIILVYLILTKSPKKMGSYKYLLIYFCCFSMLYSILYIIVEPYIHSHGSSYFMMMKLGILKSYPEVGFILILLLCGCFAVSITTISIQFVFRYFAVERKGGLRFFRGKYLIFWFISPLLAGFIWFTLAWFTQYPSPQMNDYISEIVSTNYGANVSDITYCGCVFYPLDETGVPHLDYKHLWAYVGYCITMGTLFLTLVIFGLKTYKLVRELSKHGESEYTYKLQSQLFRALVAQAFIPITFLFLPIGILFTAPLLHFDIEPASFLVTIFYSIYPAVDPLPIIFIVVDYRDGLVELLRYFIGQRNNYITPSTTDHRIASVS
The following text describes a protein:
Function:
Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence:
MAFTGKYQLESHENFEAFMKAVGVPDDEVEKGKDIKSISEIHQDGKDFKVTVTAGTKVILYSFTVGEECELETFTGDRAKTVVQMDGNKLTAFVKGIESVTELDGDTISNTLSFNGIVYKRISRRIS
The following text describes a protein:
Function:
Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MELGLGEPTALSHCLRPRWQPALWPTLAALALLSSVTEASLDPMSRSPASRDVPSPVLAPPTDYLPGGHTAHLCSERALRPPPQSPQPAPPPPGPALQSPPAALRGARAARAGTRSSRARATDARGCRLRSQLVPVSALGLGHSSDELIRFRFCSGSCRRARSPHDLSLASLLDAGALRSPPGSRPISQPCCRPTRYEAVSFMDVNSTWRTVDHLSATACGCLG
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MPPKKKGGRSSTAAATPSTATPRDDDAMDIDTPAAGTTPVPAAPVAQPPKPKFDPNDPWTDDQVASLFKGVIRWKPAGMHKHFRIIAISEHLRNHGFDPFKNPHTRIPGIWAKLRTFYDLDAIDERENSLDPPEEWGKPRRYKDFSLPRDDYGDLMLQAALAPPGDPPSSPAEWDPNEPSDERKKRKRTEAGTKTRSSTVEDTDNETSAPSPVRKSARGARSAKRAASKARKTKEESPDEDESEEEASDEEEESGDEEEASDEEEAEASTAKTARGTRARPAPKAKPVARGRSRPSRR
The following text describes a protein:
Function:
Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability (By similarity).
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein.
Sequence:
MPKHHTFATKLEDLVLTSMSFRMSKHQAHPIEPEDVIREESEDFYSDEEEYKETWSRWALQLLSSSPYDLYLIVNENFESINWDLKAKTLARPLGGTMTFLFFTVRLLQDNVIKPNYHKINRTTDGFDFSRSATLREYDYFSKYQHGASWSSANWRVNSLSILDTLLKCLYILLLVSNSVLTYKFLFGYFLKYSLFHSAQPPASNNLTKKSLHDLAYRSATDVSRGSLWTLIRYTFFQRGRVQEEKPTDEFYYEIKKWCPSSFLTALFASFPPISVWFMAFSDITFVSLLPVILTQYLFWYVIFDCYEDRIKDELAIFKGMAAEYNNKVMKPKLSAQTQDAMVDATMYGQEFVQFYPSYSTARSGVFITHSLCGDVIKEKYNQRTKAFEDIPTGSHSQNIIRYSRNERLYHSVFPQNPLKKINGAAMSVNPMSFNRSPTYGGRYGTPPSRSHGSGQTYSSTSAPTSPMLKNRRAIPTDHSTGGNISGGNYVEYTSNDVHGEPPRRHSTSPLKRDITSSAGREDNHLAFGVNSPNIRSRTVDVKKNLHTHTTVVCPKSDLDTSQLSSKQSSISPFKLSRRGSIESRPPFR
The following text describes a protein:
Function:
Transporter for myo-inositol.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTNHRSLVELTNLSFPQLALSTTKKSATNEFNGTSTEEMQPEFDDVLKNSSQQFIIQSPPPDRPGSTATWAPSVSQLESTRIGAWIWLLSIVAGIAGLLFGYDTGVISGALVLFGTDLGHTLSDLEKELITAATALAALLAGIFSSWLADVIGRKRLLVYADFIFVIGAAVMACSKNVGTMIAGRFIVGWAIGLASLIVPMYISELSPAHLRGRLVIIYVVFITGGQLLAYSLNAAFENVYHGWRYMMAFGALPAIGQLIFLYWTPESPRFLLKHNEVEKVYSILSRIHPYAKPNEIAFKVSLIQEGVAADTSDDSTTKWQRLRHSFHLLFTVPSNRRSLFIACVLQAFQQFSGTNAIQYFSATIFKSMGFKNAIATSIVIGATNFVFTCLAFMSIDHVGRRRTLLYTSWGMMAGLVMCSISYKYLKTDSNGSLLPGVSRSWPIVILLSIIVFLASYASGIGNIPWQQAELFTMEVRALGVGIATAVNWAGNLIVGATFLTLMSAITPTGTFALFAGLCFLGWITCYFAYPELAGLPIEEVSKILERGFCVKELNERNRKRRRH
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
WIAITGGIFGFVYTFGIGANDVANAFATSVASKSITLKQAVIIASICEFSGAMFLGASVTSTVRGKIFNTNLYTDEPEIVLLGMFTSLVTASFMMLVATYFGLPVSTTHTVIGCIIGFTISAKGFDSVNWDETKNIFISWVASPLLSGVIGFIIFGLIRFFILLSEHPFRRGYYTFSFILFVTIGIDIFFIFNKGYNFTHFQESVYDNRWVIPTSFGVGALIGLLWIWPVGPFVKRRMQFVRDEREAAAATNERIDASVKEIGDQLSGSFRKRSKKHKKKKILVRFAEATYRQDLEQQCFQDKATKDVWEHAEQYDEEVEQMYTYVQAFTAALSSFAHGANDVANAIAPLAAVIYIYRFGELDSEAPVNKWILAYGGLGIVLGLLLYGYKVMKTIGYQLTVTSPTRGSSAGLASSLVVATASYIGIPVSTTQCIVGAVSGVGLVEGKNNVQWWQLAKVCVSWIVIFFVSVLLSAGLFCLCAYSPSLAT
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Sequence:
MSLLCNTGDWFTLGQGNAFRKIELYTMEWPGSINLEHMRVYAAPYGGPIAVVKDPKLFVKLDGGASTRPIIRIFNCVGKLLSSINWDCGNLVTLGWSDAEELIGVQDDGTIFLHDMFGNFVHKFSVGKDVTDVADARIFTSASGTGVAVMTSGFKIYILNNIKDPKSRPLSELLNLTSSLTCWEMVCKDRTTSCLLASGNEITLVRHGDNAFTNTTPAMRHDYQSISLLAVSFDHEHVALLTNTGCLWMGSWDLKRKYCEFATGRQEQANQLVWCIDGSTGPDGQAVIVCYAHLLLVVGASGESSVYTYDTPVALIPEMDCVRVLTNYCHELVQRVPPSTSKIFGINISEPASFLFEAHRKFRDRSHQSDEYLCLIQHRLPAAVADCVQAAGHEFDPSTQKCLIQAAYFGKSFLTGYDCADYITMCRTLKVLNVLRDRNVGIPITIQQFNHLQPVVILDRLVFRKYYGLAIHIAKYLKLQETRILEHWAFQKITHDKNDDEVARKIAAKFSSAGLREPMSYANVADKAQQIGKTKLAITLLEMETKKKLQVPLLLKLGACEKALIAATQSGDIDLIYMAILEMKNTTALAKFHMTIRRYPLAQNLYKKYCQLNSLSTLKDIHSQEDDFLSQAELALREALQLGNLDASIPDISGNYRKAGKPVEADLADETKKLIRHQKLLQDKYQKDFFGLALHAMVRKLLQLGDQRYAEKLKSEFRMSDRRFWWLRVQTYADNYQWEELEKLGRAKKSAIGYEPFVEVCLAKQNVTEAKKYLPRCGEETKLKWYLRAGCYADAATIAFMQKDIDSLLKIHDHCNDSALMAKVENMIGQLSSKK