lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mL61 is not essential in cells grown at 30 degrees Celsius but is required for mitochondrial translation in cells grown at 18 degrees Celsius.
Subcellular Localization:
Mitochondrion.
Sequence:
MSSIGGKLQKSLHKIRAGALGIPLPKHIQEVSIQYSLDSRLGHMGAKKFVKECLPSLYYNNYGLKFNVNHRLPNDQTPTFSIISNNKVIYSYDMRSKQLETISSDIQKALKELHHESSPENIKEAHKQDYSPPSN
The following text describes a protein:
Function:
Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Responsible for energy coupling to the transport system (Probable).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPSGCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQFCMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALACILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIERTIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKEPIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKSTLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLFGQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEPTFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPAQLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAMQVGHSVTLPRTSYGVSNSNHALKDTSMLSWKSVRRGKQIFPGVSLKSSSGRPLSLQISDQPKTGWAAFKVYNLEKETPGSVSLSEFEARLTDLGQEVARLNNNKNIFLVGMMGCGKSTVGKILADALGYKYRDSDDEIEKIEGGLAVKEIFRLKGETQFRKTESDALRKLCEKKDLVVATGGGAVIYDANWEYLGNGITVWLDVPVKVLAKRVTAVGTGSRPLLGDGCADFESVLLKLSTLMKERKAQYSKAHCRLCFEELAKSLQSTEEHEPTVEAIVVQILEEIRHYLLHGKRTPAPELSTNLARDIEENRAASAA
The following text describes a protein:
Function:
Acts as a magnesium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MYNETLRLAQGVDALTAPLAELNTADAVEYLNTLDRDAAAHLLAVLPQPRAVKLLEQPELRDASALVAQLPAEHAAVLLGQMADDRATDIFHGLDADQREPLLWRLSAEARLSIQALMRYPPNTAGALMTTEFVAVPSDWTVGRTLQHIRDVERSRETVYAIYLLDPHTRVLQQVVTMRRLITGAAEAPILEVAQVNPPVTVDPALDQEEVARLIRRHDLLAIPVVDACGHVLGIVTVDDVLDALIAESTEDVHKFGGMEALDKPYMQIGFGQMIKKRAGWLSVLFLGEMLTASAMQHFEDELSKAVVLTLFIPLIMSSGGNSGSQATSLLIRSLALREIRLRDWWKVALRELPTGLTLGAILGVLAIVRIAIWQNAGLYDYGPHWQMVALTIGAALVGIVTFGSLSGSMLPFVLQRFGFDPASASAPFVATLVDVTGLVIYFSIAAAILSGTLL
The following text describes a protein:
Function:
Probable RNA-binding protein that plays a role in meiosis and vegetative growth.
Sequence:
MEKPLKKPMSDNSEAASTKIPYKEKNAWAIPLGSAAYHASTDTSLFSSSLPVLPHAKLNFNESDGQSIDDSSPSLSKLQLEDKIKDPLEEAESSPVGFLLPGDEDELLAGLMDDFDLSGLPSQVEDLEDDFFGSGGLEMEPEDQNNLLNGFANLSMYDGIPGSSSGHYSVPNGAATVVGEHPYGEHPSRTLFVRNINSNVEDSELKALFEQFGDIRTLYTACKHRGFVMISYYDIRAARTAMRALQNKPLRRRKLDIHFSIPKENPSEKDINQGTLVVFNLDPSVSNEDLRQIFGAYGEVKEIRETPHKRHHKFIEFYDVRAADAALKALNRSDIAGKRIKLEPSRPGGARRNLMQQLSQELEHDDIRSFRHSVGSPVTSSPPGSWSNFGSPVEPNPVRGYSQSPGLRNLSPANGNLMPGLASILPGHHSSPKIAPIGKDHARIGHLNQVTTSPKSVQGVGYQHSFSVPDQKPALSMGSMSFGNSKASGTGTLTGPQFLWGSPPIHSERTESPIWPTSSMAHPFASNGQGQGYLHSRRQSSFLGSLHVGSAPSGKPLDRHFGFFPESPQTSYINPHAFGSGGSSHNSGNQVMNIGSLGAMNMGVSLTGNFTESGSPSSRMMPMTRNGPIFFGNGSYGGAGTVNGEGLIERGRSRKFESGSNQIDNKKQYQLDLEKIKSGGDTRTTLMIKNIPNKYTSKMLLAAIDETHTSTYDFLYLPIDFKNKCNVGYAFINMVSPAHIVSFYEAFNGKKWEKFNSEKVASLAYARIQGKVALVTHFQNSSLMNEDKRCRPILFQSEGQEAADEETLPSSNLNICIRRPDGSYSGDSLDSPTGDLDGRPELFTGSS
The following text describes a protein:
Function:
Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Has a strong preference for monounsaturated monoglycerides. Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA). Involved in fatty acid ethyl ester (FAEE) catabolism. FAEEs are non-oxidative metabolites of ethanol that are transiently incorporated into lipid droplets (LDs). Their mobilization by LD-resident FAEE hydrolases facilitates a controlled metabolism of these potentially toxic lipid metabolites.
Miscellaneous:
MISCELLANEOUS: Present with 2140 molecules/cell in log phase SD medium.
Subcellular Localization:
Lipid droplet. Cytoplasm. Endoplasmic reticulum. Mitochondrion outer membrane. Note=Although the protein is identified in the cytoplasm, several membrane systems and lipid droplets, MGL activity is only measured in membrane fractions and lipid droplets.
Sequence:
MAPYPYKVQTTVPELQYENFDGAKFGYMFWPVQNGTNEVRGRVLLIHGFGEYTKIQFRLMDHLSLNGYESFTFDQRGAGVTSPGRSKGVTDEYHVFNDLEHFVEKNLSECKAKGIPLFMWGHSMGGGICLNYACQGKHKNEISGYIGSGPLIILHPHTMYNKPTQIIAPLLAKFLPRVRIDTGLDLKGITSDKAYRAFLGSDPMSVPLYGSFRQIHDFMQRGAKLYKNENNYIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIQDCPSADKELKLYPGARHSIFSLETDKVFNTVFNDMKQWLDKHTTTEAKP
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus.
Sequence:
MDIDFCSHHLLAYDNSIINDENEIKAKVEQNLPLIFSKINKLQKEKEDEEDIIYSVTNDNIFNMPRYSRIPKEKKKTKWQLFAENKLRMKKNKSGLIYDKVSKGWVRRFQKKQIKLNEQKNNFVHEYKNKEDIYEDPFEKEQEEKDIKKMKQKMRELKNKFDQKGISTEDIKYIQRQKRKRENLIDNLKMAQISSSTFGRKDKKLKKEKKLKLQNDKITNQKYEKRDLKDEVKQNNRLAALVLKSV
The following text describes a protein:
Function:
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC; Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MHPQQLVVSWFSLVLLASPIVAIWELEKNVYVVELDWYPNAPGETVVLTCDTPEEDGITWTSDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSRSLLLLHKKEDGIWSTDILKDQKEPKAKSFLKCEAKDYSGHFTCSWLTAISTNLKFSVKSSRGSSDPRGVTCGAASLSAEKVSMDHREYNKYTVECQEGSACPAAEESLPIEVVMEAVHKLKYENYTSSFFIRDIIKPDPPKNLQLRPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKNKREKKLFTDQTSAKVTCHKDANIRVQARDRYYSSFWSEWASVSCS
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MLVSNISGKLMSQLMEKMKERLEKMKRTVRQQRAKLHIIRICITMLLSSDDYS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTDAANDGGFSPFNITNTGSAPPERLKRWRQAALVLNASRRFRYTLNLKKEENEKHIRAHVQAAANLFNGATEAVMFTIEYPDLPHGGYGVTPEVLADMSKNHDLSELQKFGGVTGLAEKLKSNVEQGIPGNDEDILQRKNVFGTNTYAQKKGRTFWRFLWEACLDLTLLILVVAALASLALGIRSEGIKQGWYDGGSVIFAVFLVIVVTAISDYQQYLQLRDLRNLNGQERNIHYEITRGGRRVMSSIFDIIVGDVIHLKVGDQVPADGVLISGYSLAIDESSITGVAKIITMGSKTPFLTSGCKVADGFGTMLVISVGVNTEWGRIMSSIPEDICEETPLQVRLNGLTTFIGLAGLTVPFIFFVAVLIWYFTGHTTNVNGTPQFERGKTSAIHALGGVIKIVTVAVCVVQLSWIFFLFLIHMLSILWVLHLLTFQVAIIVVAVPEGFPLFVTLMLASLMKKLITDKAMVRRLSAIETMGSVTTICTGKTGTLTLNQMTVVEAYANGKKFDPPNDGSLLSPMFSSVLIEGIAQNTTGCVCLPKGGGDVEFSGSPTEKAILSWGVKLGLNFVAKRAESTIIHASPFNSEKKRGGVAVKTPSSEVRVHWKGAAEIVLASCTSFLDENDSVMSLDEDKLAFYRKAIKGMAEKSLRCVAIAYRSIKLDKVSSDEEQLRQWAMPDDELVLLAIVGIKDPCRPGVRGSVDLCEAAGVKICMVTGDNLQTAKAIAVECGILASDADCNEPNLIEGKSFRSKSEAERENIAEKISVMGRSSPNDKFLLVQALKRKGQVVAVTGHGTNDAPALNEGDIGLAMGIAGTEVAKESSDIIILDDNFHSVVKVIRWGRSVYANIQKFIQFQLTVNVAALIINVVVAISTGDVPLNAVQLLWVNLIIDVLGALALAKEPPTDHLMHRPPIGRREPLITNVMWWNLFIQAVYQLIVVLVLDFFGQNILPLRHDSIELANEVKYTMIFNTFVLCQIFNEFNARRPDQLNIFDGIIKNYFFIGIIALTLILQFMIVEFLGKLVKTVKLTPQLWLVCIVIGFISWPLAALGKLGPVPKTPVAWGVIMVLVGIVIAILIGQKYTDK
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MTTLILTEKPNVAKRIASILSEGAKAKREGKVYYYEFDTGGERYYVAPAAGHLLELDYPPGKWEYPSIVPPERLVLKEIKGKREYLKILEKLGKLSNRIIVATDLDSEGSSIALEIIKALNWEGKEILRMEFSSLTKEEIRSSFRDLKPFDYPRAYAGWVRRVIDLEWGANVSRGLTLSTRRKGWVRVLSSGRVQGPTLSMIVKREREIREFVPKKYYTVIVKVDKGFSLELAPPKGEERIWDQDYARRAAESVKDTLIARVKSDERKLSPPPPFDGTSLQVEVSAITGLTPRQIADRTSGIAQKLYEAGLISYIGTESQKYPKSWKKKDFVDMVKLIASYSPLKEEAEFVLGDMREAAVEGKKDDPAHPTIHVVGVPEERLEGKYREVYEIIARRNLATLAQDALIKRIRVESNVDGFIFRASGLSVLREGWLRVYPYARMEEFPEVEDSEELRVVEVKIEEKETQPPKRYSHISLIKEMERLGLGTKNTRVQIIDILKSRGYLEEGSFKPTRLGEAIVEVLESFVPALTNPELTAKLERGMNEIELGKLDPSNFLKESLDELSAIMDEFKRNELKISERLYEGLREYRSGSLGKCPECGGDLNMRKSSYGYFIVCSNYPEKCDVKFNLFKNERFEGKFCECGLPLVSGRIKTKSNRGRGYTRCIANCDRTPLRCAKCGGPMVAKQGKFGVYLKCENCGSTNFFRVRKH
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIKQAFKEAVFRAIFFMSATVAVVAILLICFFIFSNGLPFMANYGFARFLLGSDWSPTNIPASYGILPMIVGSLLITLGAIVIGVPTGILTSVFMVYYCPKPVYGFLKSAINLMAAIPSIVYGFFGLQLLVPWIRSFLGNGMSVLTASLLLGIMILPTIISLSESAIRTVPKTYYSGSLALGASHERSIFSVILPAARSGILSAVILGIGRAVGETMAVILVAGNQPIIPSGLFSGTRTLTTNIVLEMAYASGQHREALIATSAVLFFLILLINAYFAYLKGKSSYE
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLMVSQLKKFDAYPKTVDDFRVKTFTGAIVSIVGGIFILWLFFSQVTLYFSTDIHHELFVDTTRGEKLKINMDITFHHLPCAYLSLDAMDVSGEHQFDVAHNIFKKRLSSTGQPIIEQPPIREEEINKKIVKNENDVQGCGSCYGAEDPARGIPCCNTCEEVRNAYSKKGWGLDPSTVSQCLREGFTKNIVEQNGEGCQVYGFILVNKVAGNFHFAPGKSFQQHHMHVHDLQPFKDGQFNMSHTINKLAVGNEFPGIKNPLDEVTKTEVAGVGMFQYFIKIVPTIYEGLNGNRIATNQYSVTEHYRLLAKKGEEPTGLPGLFFMYDLSPIMMKVSEKGKSFASFLTNVCAIIGGVFTVFGIFDSFIYYSTKNLKKKIDLGKAY
The following text describes a protein:
Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAPAALWVALVFELQLWATGHTVPAQVVLTPYKPEPGYECQISQEYYDRKAQMCCAKCPPGQYVKHFCNKTSDTVCADCEASMYTQVWNQFRTCLSCSSSCTTDQVEIRACTKQQNRVCACEAGRYCALKTHSGSCRQCMRLSKCGPGFGVASSRAPNGNVLCKACAPGTFSDTTSSTDVCRPHRICSILAIPGNASTDAVCAPESPTLSAIPRTLYVSQPEPTRSQPLDQEPGPSQTPSILTSLGSTPIIEQSTKGGISLPIGLIVGVTSLGLLMLGLVNCIILVQRKKKPSCLQRDAKVPHVPDEKSQDAVGLEQQHLLTTAPSSSSSSLESSASAGDRRAPPGGHPQARVMAEAQGFQEARASSRISDSSHGSHGTHVNVTCIVNVCSSSDHSSQCSSQASATVGDPDAKPSASPKDEQVPFSQEECPSQSPCETTETLQSHEKPLPLGVPDMGMKPSQAGWFDQIAVKVA
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAKFPFLFSFLFFALIVSGNHETQRTVISKMVDGVRGKIGAIVDKNSRIGKEESLAMLMAVEDFNNVNDQNFSFVIKDFKNDPNQAALAAEDLISMQQVQVLIGPQTWEAVSVVAKVGSENKIPVLALANDIPKWATERLAFLVQASPSQFNQMRAIAAIIGSWDWRLVNVIYEDGDFSTAEVFSYLEHALKDVGAEISELVSLPQFDSNLLSNELERLRRGPSRVFVVHTSFKFGLHLFQTAKEMGMMEKEYVWITTDSFTSLAHSFNVSVNSLLQGVIGVKSYFPENHPPFRKFYRRFCSRFRIEHSDEYNHEPSIFAVQAYDAVRTAAMAMSRAQGKAHRLFKFIKLADFQGLGGNIQFKDRKLVPANTFQIINVMGRSYRELGFWSVELGFSRELGKNSSTSSSLKDLGPVFWPGGYFETPRGWAIPTDARPLRIGVPTSPMFKQYVNVEGDQIGNNLSFSGLAIDLFKATLDNLCVPLPHKFYAYSGTYDDLVKQIYLKEASASNGIFLFCLSKEFDAAVGDIAIVSTRYEHAEFTHPYSEAGLVMVVPAINNRSNRALLFTKPFTLTMWIVISVVNIYNGFVVWFIERNHGPEPEGSMFSQAGTMLCSSFTTLFSLQGNRLHSNLSRMTMVVWLFVALVITQIYTANLTSMLTIQQLEPTISNIETLRRMNAFVGCGRGSFVKGYLETVLHFSTEAIKNYSTPDGLADALRNQEIAATFLEVPFAKLFLAKFCKEFMISGPTYKVGGFGFAFPRGSLLLPYVNQALLKVSETGRYRKLEDSMIAGEKCEDGEGKDGSPSLSPNSFFLLFVLSAGVSTIALTLYVYNATLKSNLQQNTIWRLMIAVMRKWGNHRRRFSRRVSEEPQTIPNNFPNVENVQSLA
The following text describes a protein:
Function:
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of a-specific mating genes.
Miscellaneous:
MISCELLANEOUS: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA); MISCELLANEOUS: Most C.albicans strains are heterozygous at the MTL locus and do not readily undergo white-opaque switching and mating, but mating occurs in hemi- or homozygous strains. Mating takes place in opaque cells, produces tetraploid progeny and seems to occur rarely, if at all, in nature. Conservation of mating capacity is rather thought to be due to the simultaneously regulated white-opaque switch, which seems to play an important role in host commensalism.
Subcellular Localization:
Nucleus.
Sequence:
MPYTFNFPKSQSSFKYSIKSLTNSRSFPMISIYVTPQSTPKFINNQSIDKMTVLSSFRSRNSFIIARSILSKLLRKNKADFKKVSKSVSLLWGSVDNSFKNYFEYLSILESQWHDKKSSNLNPISSTRTTSELNYIELCSSIYNQSRKHPRSVQGNKAKFRLYKNVSKKSNRKPRRLKNGFKVSRSTINCSYGIYTEDVFQ
The following text describes a protein:
Function:
Necessary for formate dehydrogenase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNVYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEANDQGKPPLDIHVLPRDKHWQKLLHSLIAELKPEMSGPALAVIENLEKASEQELEQMASALFASDFASVSSDKAPFIWAALSLYWAQMASLIPGKARAEYGEARQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSRDLHYWSLENEQAAVKAESCGDCGTYLKILYQEKDPKVEAVADDLASLVLDARMEQEGFARSSINPFLFPGEGE
The following text describes a protein:
Function:
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
Sequence:
MRRIISVLLENQSGALSRVVGLFSQRGYNIESLTVAPTDDNTLSRLNISLVADEKVLEQIEKQLHKLVDVLKVSNVTESAYIERELALVKVRAQGELREEIKRTADIFRGQIVDVTANLYTIQLVGTTEKLDAFIHSMGEVTKVVEVSRSGVVGLARGEKAMKA
The following text describes a protein:
Function:
G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production. Plays an important role in microglial function, controlling morphology and phagocytosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLKPSNDSVLVSSNEPSSTSSSVSERMSSPNSSVDNSSIVYTNTTCEIQDQFLSLVLPASYSVIFIIGLLSNTVALCVFFFSKKTNSSISVYMKNLAIADFLLVLCLPCRIYYHNRHGPYLLCKTVGVFFYINMYASILFLSLISMDRYLKIIKPVWVYKIQKVEWSQRTTRAMWIILVCGMLPFFFENKGTQPCDDVCFHFHKKSLVGGIINLIVVGFFYFLSLIFLGFYGKIAMKLKKMFLGNAPQKAKSRKTSAIIKTFLVPVIFTLCFMPYHVVRVPYVLSQMNIIQELNSKQTLHILNELVLCLSALNSCLDPIIYFFLSCTFRKTILCAIQGFHLFHNANSRVSKIDHFKNKNTIYHMYLTFYCYVTRGK
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MIQLGDTLPDGILYHIDAATRILHILSIRHLFAHKRVLLLGVPGAYTPSCRQVTFFPRSCLISSYSLRLSSVEHIPGYISKAPSLHAKGITNIYCLTVNDPFVTHQWSKTFADNNDAVRFLADGSATFTKALGMDIDLTRHGMGVRGRRFVLFADNLRVRKLIVEYPGEAANIAVDDVLKLFI
The following text describes a protein:
Function:
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
Subcellular Localization:
Cytoplasm. Membrane.
Sequence:
MSNFSSRKKSPVGNDPKSTQGAALRQQGFHDVNKRRAFLQDNSWIKKLPEEEKDENYGRVVLSRHNSHDALDRKITERDEPKATISRYRSEDMLDRSLSTFRTPESTKTPAGSSFSANTTAPSTPATTPVKKKRQSWFPPPPPGHNAPPSTGASRRDPPLHPPLPPKPCSPIASPKQLRQSHRQMHMATAGACGEADRHAARNIRTEDLDDIIRVAAALQKTDKGEELDNLIRMNKSLNRNQGLDGLFRANLKAQQLDKRAQSLESLIYMNTQMDRDGKGNQAFGSFKKINQRADTERGSQDQRSIIRTNAMAERSSRRKQDLGGLINVNPETNKSMKRGQSLENLIKVTLEVNRSSKGGQSLDNFIKAVPATDRANQGSQGLDSLMKVTPSANKSNQHSLDELVNTSPKAVKTTAGHQDLDKFIKVNADVLTNNQRNHDLDNSIRGNPTVNRCDQSHDLDNLIKVKPSALRNTNGDQDLKGLTEVNSRVSEDKNERVDGQANGVTNSLRKESPRTSVYSHETKTSLSSNSGTRNAGPKDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKRPLENLQAGDSIWIYRQTIHCEPCYSKVMAKWIQ
The following text describes a protein:
Function:
Probable GTP-binding protein that may be involved in cell development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSSITPTTSLRKYDVFLSFRGPDTRRNFISFLYKELVQRNIRTFKDDKELESGQRISPELDRAIEESKFAVVVVSANYAASTWCLEELVKIMDVENKGSLTVIPVFHGVDPCHVRRQIGQVAVQLEKHEMREDREKVLSWRQALTNLASISGVCTLKWEDDSMMVDEIAKRISTVIDTTRKPTRTGSNLVGIDAHMKALSRLVDLNSSKKNVRVVGIWARGGNGRSALAKFVYQNICQHFESHCFLENVKRTSQDRHMSHLRQEVLKRVQVESNQKVLLVANEVNKLEHFDALAEDFSCFGPGSIVIITTQDKQLLVSAGIKLVYEVELLRFRKVRELFRQLGFRVRERAIESVLYKSEGCCSVQLIDGDGIYNVSGIDHFIKEVKLGECGLSYAVVSIMGPQSSGKSTLLNSLFGTNFMEMDAFKGRSQTTKGIWLARCAGIEPCTLVMDLEGTDGRERGEDDTAFEKQSALFALAISDIVLINMWCHDIGREQAANKPLLKTVFQVMMRLFSPRKTTMLFVIRDKTRTPLENLEPVLREDIQKIWDSVPKPEAHKETPMSDFFNVEVVALSSYEEKEEQFKEQVASLRQRFMHSIAPGGLAGDRRGVIPASGFAFSADQIWRVIKENKDLDLPAHKVMVATVRCEEIANEKFSHFISNEDWRKLDEEVQAGPVSNFGKRLTSILGSCLSEYDGEATFFDEGVRSSKRHQLQEKLLQLVNPAFQDVLGHIRFGMLEKFKASFDKALEIGEGFSSASSAWFKSCMAQFDEECAGAIVEQADWDTAKVRDKLVRDIEVHISSIRTSKLSELTSQYESKLHGALSEPVEALLEGANDETWRTVKKLHRRETESAVSGFSSALACFDIEEEIRDKMVKSLQEYSRGVIESKAKEEAGRVLMRMKERFGTIFSHDSDSMPRVWTGKEDIRAITKAARSASLKLLSVMVVIRLGDETDNIEKTLSVALLDPTTSKKSITASDPLASSTWDEIPSSRTLITPVQCKSIWRQFKTETEYTEANKRGSNWLPPPWAILALILLGFNEFMTLLRNPLYLGLLFVGFLLLKALWTQLDIPGEFRNGVVPGLISISAKFVPTVMNLLKNLAAEGEAPPTANPENRRPSNNTSSHASSSENPTEHKSGSKTD
The following text describes a protein:
Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MFKLPELGYDYDAVEPYIDAKTMEIHHSKHHNGFVMNLNSILEKMGKIHLTDVSNILKNIHDFPEEFQTLIRNNAGGYSNHTLYFRTLRPGNKDNLFEKFKDDINAAFGSLDVLKANLKDTAMKIFGSGWAWLVLCPESGLKVISMPNQDSPLMNSYKPILGIDVWEHAYYLKYQNRRIEYVDAFLKALNWEEVSKVYNEVIN
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MPVINIEDLTEKDKLKMEVDQLKKEVTLERVMVSKCCEEVRDYIEERSREDPLVKGIPEDKNPFKELKGGCVIS
The following text describes a protein:
Function:
Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Secreted. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment.
Domain:
A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding.
Sequence:
MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRVMSQLELLSGGEILCGGFYPRVSCCLQSDSPGLGRLENKIFSATNNSECSRLLEEIQCAPCSPHSQSLFYTPERDVLDGDLALPLLCKDYCKEFFYTCRGHIPGLLQTTADEFCFYYARKDAGLCFPDFPRKQVRGPASNYLGQMEDYEKVGGISRKHKHNCLCVQEVMSGLRQPVSAVHSGDGSHRLFILEKEGYVKILTPEGELFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDVRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGRDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGASSSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRVTVQPAQPLTSDCSRLCRNGYYTPTGKCCCSPGWEGDFCRIAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNVRRVTRAGILDQIIDMTSYLLDLTSYIV
The following text describes a protein:
Function:
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MNRIVYAVLLAFLISILGGPILIPLLHKFKFGQNIREEGPESHRKKAGTPTMGGVIFILSSIITMALTIRRPGDEAMVALYAFIAFGIIGALDDGLKIIHKNNLGLRAYQKMLLILVVSGIFGYYSANNPNIGTSIIMPFTRKSLDLGAFYIPGIIIYFAATTNAVNLTDGLDGLATSVTLLVMTFFALVSFGMGHYTLAIFCAVVAGALLGFLRYNAFPAQVFMGDTGSLALGGAVAAVAMILKLEILVIIVGGIYVLETLSVIIQVLSFKLTGKRVFKMSPIHHHFELSGWHETKVVSVFSIITVILCLVAFLAL
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSWLLRSTKSKLLSSSSSLSRTFPSLSRSGPTLDLPQIGAISPLPDLFHRNTATMPFAKENASGGNLAGLPKVPANTLGSDSNAINSPRYKASGLDTNVLAGARCVSGVWAAQGPMRLVVNTVMARSFERSMEAGTLGMIGHKRFMSDIPSKTSETNLSGFRPLSPHLPLYQPQLSSTLSIFNRIAGAFLAGVILLFYMIYMKLGLVSLTYDSFYQFIFYSSKLNLLVMEISALAVSYHLYSAIRHLFL
The following text describes a protein:
Function:
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2D/RPB4 is part of a subcomplex with POLR2G/RPB7 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA.
Subcellular Localization:
Nucleus.
Sequence:
MMDSAWSRPPPAASGSAPARPSLLPPRPQRLPVPVLPASFPPSPAPPSSPAATSGSGPPSLPPSLPPSLSLPLPLPLPSSPPSLSLLFPPPSPPLSPPLPLFPSPLPAPSLPSPRGHFRPRPPPPRRLPVPVRVGGGAGRAMAAGGGGGGGGDPRAGDVEEDASQLVFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEEAKALIPSLEGRFEDEELQQILDDIQTKRSFQY