lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the modification of the lipopolysaccharide (LPS) lipid A moiety. Catalyzes the transfer of a galacturonic acid (GalA) residue to the 4'-position of 4'-dephosphorylated lipid A, using dodecaprenyl phosphate-GalA as the donor substrate. Acts before the other GalA transferases RgtA, RgtB and RgtC.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSPRSGLLIVLGFTLWRVVMLNFDATDFFVDEAQYWFWSQNLDLGYYSKPPMIAWVIRAMTELSGSNAIYWIRLLGPLIHMAAALVLMKTAKRFVGPEIEGWTGATYITLPGVALSSVFFSTDVILLFFIAIALLAYFGLTQRRSVGLALVMGLGVGLAFLTKYAVLFVVPGGAIALLLIPAARIAVRDVIIAVAVAAVVALPNLWWNLQHDNTTVRHTQDIAHWSELGINLRRGLEFFAAQFGVVGPIIFFAMLWAVYRMIRGRSDDREKMLVWLSMPVVLLITLQATVAKAYANWAVTAYVAGTILAVWLLYLKWPKGLRLSLTINGIASLLFPLATIFPHQLLLPNGDALMKRYLGRAEVSREAAALATQAGTDIIVTDNRDMVADLFYTLRDASYRIYARAPAGLPESYYEQEFALPADITGKVLFLTDGAFTCATETPEVLKNWQPTEGNYKGKTLSIYKVSATCLAP
The following text describes a protein:
Function:
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
Subcellular Localization:
Nucleus.
Sequence:
MPPVLSMSGSNYDYDYDTIQPYFMDEETFYPPSLCQLLPGPGEDIWKKFELLPTPPLSPSRAPSPSNTSLSAADHLEEVSNLLDKDFTASETFLQSFIIQDCMWSSSFPAAEKLEKVLSEKLVSLKASSTCSTSAVSSLTGGAAVLSQTEVNPEYLRDLQAAAAHCIDPSVVFPCSTVSEKQSICEEQMEVGPELCLDSPPLSSSDNESEDEEEENCEEEIDVVTVERQKTPRRCALTPLVLKRSHINIHQHNYAAKQPAAKRPKAESAGARQSRRCWSPRSDGEDSDKRMTHNVLERQRRNELRMSFLTLRDEVPAVANNDKAAKVVILRKATEFIKEIRGDERKLLTTKEELRKRSRELKRRLEQLRTLH
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane. Membrane; Peripheral membrane protein.
Sequence:
MSNNTLQEALTEVRQQESQMRRCLEHKGKIMDAVKHASTLLAELRSSTLPPKQYYELYIVVFDALAYLGAFLKDSHPTHHLADLYELVQYAGNIVPRLYLMITVGTVYMGMDDAPVKEIMKDMMEMCRGVQHPVRGLFLRYYLSQRSRDKLPTLPEGDENAATKGSLQDSIQFVITNFIEMNKLWVRLQHQGHSRERDKRTAERQELQILVGSNLVRLSQLEGIDKTYYRESILPAILEQVVQCRDILAQEYLLDVITQVFPDEFHLATLDIFLDTIANLNPGVSVRRIVITMIERLAAYAAREAENETNTVAKQLKEAHLDDAVDNDKDGDDKGKDKDEEVTDPLTAPSASPYTEEYHRGIPASMDLFKVFWDHFLGLLKARPDLPLEDQMAILGALTKLSMNAYPERLEFLDQIFSHAAEKLKAADSAATSSKETVDALLAMVLAPINFYSRLLTVLSVPSYLELLQSQTAASQRVVAIAVIDSVLKEQAHITDIGDAEGVFGLLQILIVPRGAAAQSEDEESEDVAADQAKIAKVVHLLYHKDPDTHYKLLVVARKALSAGGQLRKYTYPALVFSTLRIARRYKARESVFVDWMQRTTALFKFIHKLISDVSITGRAEYALRLYVDAAQVADQCGAEEAAYEFFVQAFTVYEEAVSDSRAQFQAICIFVSALQQTRNFSLDNYKLLISKTAVYGSKLLKKPDQCRAVYMASHLWWTVDDDDEDDDENKETPEGEESGTASVRDGKRVLECLQRALRVADACMDVAVQVQLFVEILNRYIYYFDHGNTEITVKYINGLVEVIQNNFNDDGAYDAQNIEAPKKFFDRTLDYIASQKEVDERYESIVW
The following text describes a protein:
Function:
ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MEPAPLKLLPPDPGDEGTQRCRLGPAALSSLGVRLGAPLRISLPAGCCLCTAWPRPDLADGYVQADPACSTGLTAAELRGLTLSPGLLQPLSSRRLRGAAVRAVLRGGAPRRAAGLQEAVRDLLTNVYVSPHYVVTVGPNVRAPVLHVEILSVDPVTEEAGLITPQTSVTIKEVITLERYRLLTEDTAKIPVAGLDDVGESLKEMVDLPFRFPRTFKKLGLSVPNGVLLVGPPGVGKTLLVKAVAREAGAYLLCISGPALYGSRPGESEENLRSVFEKGREMSCEGPTVLFIDEIDALCPKRGSSNSAPEDRLVAQLLTLLDGVGRKDRMVVVAATNRPDALDPALRRPGRFDREVIIGTPTLTQRRSILQMLTCSMPISTDIDLVKLAEMTTGYVGADLTALCREAAMQAVFHSSLDSAEVLINMADFQEAFKKIQPSSFRSAIGLKECKPITWEQIGGLEDVKLKLKQSVEWPMKFPQAFARMGLARPKGVLLYGPSGCAKTTLVKAVATSCHCSFLSVSGAELFSPYVGDSEKILSQVFRQARANTPAIIFLDEIDSILGSRSHSKSGHGVSERVLSVLLNELDGVGLKVTERRGNKLQLEGRCEELSDEERQLEFQETLSRDFMVVAATNRPDMLDDALLRPGRLDRVIYVPPPDLKGRLSILKICTEKIPLDTDVSLQDIAALTDLFSGADIENLCKEAALLALQENGLEATAVKHGHFVKSLETVKPSLSMKDLEFYEKIYSQELTT
The following text describes a protein:
Function:
Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
Subcellular Localization:
Nucleus.
Sequence:
MCSLPRGFEPQVPEDLERRSLAELREMLKRQERLLRNEKFICKLPDKGKKIFDSFAKLKAAIAECEEVRRKSELCHPVSLDCKLRQKAIAEVDVGTDKAQNSDPILDTSSLVPGCSSVDNIKSSQTSQNQGLGRPTLEGDEETSEVEYSVNKGPASSNRDRVPPSSEASEYHLQHRVSSQAEDTSSSFDNLFIDRLQRITIADQGEQQSENASTKNLTGLSSGTQKKPHYMEVLEMRAKNPVPQLHKFKTNVLPFRQNDSSSHCQKSRSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQRKQKYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF
The following text describes a protein:
Function:
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MCDSDIKVKQLEKRASGQAFELILSPPSMDAAPDLSITSPKKKECSLEEIQKKLEAAEERRKLHEAEILKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTTKMETIKENREAQIAAKLERLREKDKKVEEIRKGKECKEPSEK
The following text describes a protein:
Function:
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Cell junction. Cell projection, microvillus membrane; Single-pass type I membrane protein.
Sequence:
MLLFFSMLGKKKLSENFLSFSLAQNTALGTILFKVTATDEDSGLAGVVSYSIDEVVPDDSSLFKINRSGEVLLNGFLNYANKSTFYQLTINASDGGGELYGQAVVQSTSAFAFITIEDVADLDPDFLNLPYQTSVKEHTPVGTSVFKVQAVDGDRGIKDKIFYSIKETNAPGLFDIDRNNGVITVKGEIDREALLNITATVNLQVMAEEENPNIHGQNAMTSAEVIIKILDINDNKPKFYNCMESECDFSDSSVANSFTGDIQEHASGGVPVANMTITVRDQDEGNNAKFNLRLEGEDKDAFSVSPTTAMSSAQVQILVKSPSEVNYESKTMMRVEIVASDVANETYYCSTATVTIALIDMNDNRPEFKQETYQLQVNENSPNGKALMTITASDPDTADEGKITYRLLPDSILPYFEVGKESGTIFVKNSTLLDRETRPIYFATLQAIDTANNTGTAVLEITLIDENDETPEMARDYYIDFVEEGKDGHLQLQIQAFDKDEPGTNNSEIRYRIEPSEFSDNFTINEKTGMLENNGPLDREAIDPSLNGAIKLIVTAYDLGFPSMSSSVNVTINVEDINDNKPVFAPDTYDFSVNETEKGAFVGLVFAQDADQTEIHNRISFSITDGSFGNFIIRTFYDKDLKRYRGNITVDPDVELNFEAVKNYTLTVEATDLGLQEDRARVKVKVLDVNDKPPTFEDGSLKDLGVKENTTGLGVVRNITGTDEDTKHSLVYHLLSVKCLCNLNVSADDCEKDWFRLELSGSLLVNNDFVIDYEQCHEVQMEIQVVDILTEKGVNHSSPGILKIHIIDINDNAPQFISSETLFVVVPEVAAKDSEVGRVTAKDRDSGENKVIVFDVLTVEFIHSNGDKETMSNLFYADTVKEIEDYAGIIRTSNTLNTNLKGRYLVTVGAKDKGVPSLNTSIQLDVYTVDSSFRVQLEFRSSIQEIDANIDTIKGVMVSATKATVHIVKIESKEQAQRASEFTVLVAYFVYPNGSAIIPSNIITILQEDRTAVDVLYRYGLQYIESGEKESKEIDPVYYAVAGLAAGFVILLVIMITTLVCTQRSYKRKLKAANAVKSAAFMGADNRHTGQVVPGTNKYTMEGANPVLNLNIDSATDLGFDEEGSNIDRVSLDSLDENLDINMSEKENMHMMMIQEEDEENPNEPHYIEPLGAALAQHRKKDNGETHTFTNPSLDTTDL
The following text describes a protein:
Function:
Required for anaphase spindle elongation.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
METATSSPLPIKSRRNSENSGSTTVIPHMNPSLATPLTVSTMVNQSNSKEFMKLTPVRIRDFGSPLKNVSTNYHFLDSENGKGNTMDNMYRENFILISKDLEKLLENLNVIYQNIGYSNTEIITKEKIIFTTISNSIKQFFEQADEELKRLSAENGIEQDILNNILERINDPSGIKTIPDLYIRNAILLQESKTVPQSPKKPLSLLSKKAALDTAKKFVLGSFLPRLRDYLKSLITLKHLIQSVKENLPGLTEADNEAIAEFPELSTLTAYLLQIENGKGDIGLSMKFIIDNRKDILKGSAFKTINEESVKHMNEVIKIYEEEYERRFKSVLTKKVSISSICEQLGTPLATLIGEDFEQDLRSYGEEENSTSEIPNFHPVDRERMSKIDITLEKLQAIHKERADKKRLLMEQCQKLWTRLKISQEYIKTFMRNNSSLSTESLGRISKEVMRLEAMKKKLIKKLISDSWDKIQELWRTLQYSEESRSKFIIVFEELRNSATTLQEDELLLETCENELKRLEEKLTLYKPILKLISDFESLQEDQEFLERSSKDSSRLLSRNSHKILLTEEKMRKRITRHFPRVINDLRIKLEEADGLFDQPFLFKGKPLSEAIDIQQQEIEAKYPRCRVRMQRSKKGKCGANKENKVIKNTFKATESSIRVPIGLNLNDANITYKTPSKKTIQGLTKNDLSQENSLARHMQGTTKLSSPNRRATRLLAPTVISRNSKGNIERPTLNRNRSSDLSSSPRINHTHGEHAVKPRQLFPIPLNKVDTKGSHIPQLTKEKALELLKRSTGTTGKENVRSPERKSSLEDYAQKLSSPYKEPEHSIYKLSMSPEGKFQLNIQQKDIESGFDDTSMMEDENDKDFITWKNEQVSKLNGFSFTDI
The following text describes a protein:
Function:
Required for the assembly of the RNA endonuclease module of the integrator complex. Associates with IntS9 and IntS11 in the cytoplasm and blocks the active site of IntS11, thereby inhibiting IntS11 endonuclease activity before formation of the full integrator complex.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The BRAT1-like motif mediates inhibition of the endonuclease activity of INTS11 by forming hyrogen bond and hydrophobic interactions with the active site of INTS11: Cys-973 coordinates one of the two active site zinc ions of IntS11.
Sequence:
MQKQEETLSRLRTIFDIFLRENFSTTNNVYFEKLLTHLQAKENAFVLQAPFVVEWVDRCITAVTEDFKKIHPKVISFMLNLTSFLANNEWMIVRLRELDIVNRAVKLLQREHNLSPSIKLGGIRLMKAITVYSMGLAFLRMHRIWTLLIQYSNNDHTLYVVREARQVLYNMVYKSCDKLHDKAVTLEILSEIMQPIHDNLYKNTDGVERIHVKVDDNEMLHKISSTLDLLSYILQQTLVLEERTTLIILLKEHHDFEITVWKLIDMTHNPYFTEKIFTTLSSYNFALLLHEKLLNPNATEPSEEFTEFGLAFFNLMKFLITRKDGLSFVKLAELNHVLWKKLGPRAPKEIVIQQERVTFENQLICFHMLPLLFSMKYAQKIADEESKIELFDAYVVKLLEISCEQTLRLCYTMRDNFFSADGMAVGLVTAGLANKCIHSLLALENVLDREQAVTVCQALLYVLREAVAMSVITNNGEDDCHSVSSAGSSYLKLYPRGTEQVVNDPQVLHSVMVGLRTLIERFKITWKESVETIGLVNCLAFVLENTSMDARCTVQALKLVQLAVEHFLSPNMALLVDNLQGSALVCLGPIIVKRMHDTMWEVRDTTLELTTSIASISRIKFPAFQRFLIDSKIPPIVYEMAKNDSEVYVRASAFQCLSQMVSINLLWENGLSQLDLVDHLLFVMYRETNDIVRSEAVITLMKIYEHRKIHEKYKNTLFSTLNYCVIGDHHTEVKLNALNFWRREFYRQFSNQGMIDGSFPTVTFSKEQKKIVTLTEKEIQTSIAKVFGEVQQYGYFGILLKCLREETSMEVLEFLIKGVKTMTEKFERYKGIMEEIEMRSPLSDRERPRFDFPSQPQPTPIPQQPPVNPTEADEVIESILNSQDAQLLEKAFETQMQINAQGKTAEKRHIDEFYYKQFAVPLRQFFEELKTIDLDQLVKQHQEWFECKENFTSLLDDILGALKRDDENMISDCY
The following text describes a protein:
Function:
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQDTICAIATAQGGAIGSIRVSGPEAISITSRIFQPAKAGKLLSEQKPYTLTFGRIYNGEEVIDEVLVSLFRAPHSYTGEDSTEITCHGSSYILQQVMQLLIKNGCRMAQPGEYTQRAFLNGKMDLSQAEAVADLIASSSAATHRLAMSQMRGGFSKELTDLRSKLLNFTSMIELELDFSEEDVEFADRSALRKLADEIEQVISRLVHSFNVGNAIKNGVPVAIIGETNAGKSTLLNVLLNEDKAIVSDIHGTTRDVIEDTINIGGITFRFIDTAGIRETNDTIESLGIERTFQKLDQAEIVLWMVDSSDASSQIKQLSEKIIPRCEEKQLIVVFNKADLIEEMQKEELSALLKNFPKEYTKSIFISAKERRQTDELQKMLINAAHLPTVTQNDIIVTNVRHYEALSKALDAIHRVQDGLDSHISGDFLSQDIRECIFFISDIAGEVTNDMVLQNIFQHFCIGK
The following text describes a protein:
Function:
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MIPPIFALLLAVSVAEVLVLTQDNFDSELEKHKNLFVKFYAPWCGHCKKLAPTWEEMSNEYTTMPVAEVDCTAHSSICGKYGVNGYPTIKLLQSSGAVFKYEKAREKDEMMKWADSMLEPTLTKCDSVEDCAEKSRKVRALNYFLLEAPEYKEIYESYFTDFKGEHFFGFLKAKEWKLTAVREGEHIVYKGTENSNVNYIKKFVASHRYAFLPLLGQDNAAALIHERGRPTVIFALDTERDNKLLKTLSKFAREIILNPKDETSFIEMRYTLTFSDTGSWKQFFEGIDVDSSAGPKIVIYDNASPKKQVFQADFGEDPVGSIIEFLKKHKTRQLTGVPLGKDGRVVRPDGDKEL
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for sensory cilia biogenesis.
Subcellular Localization:
Cell projection, axon. Cell projection, cilium. Cell projection, dendrite.
Sequence:
MSYRELRNLCEMTRSLRYPRLMSIENFRTPNFQLVAELLEWIVKKFEPESNLDAHEVQTEADRVAFIKNAVLLMLQNSRIKMNPKKLYQADGHAVQELLPAMKILYQAKAEDPNTDNSPKWTQVKNKLSSKMQEVRITRQLSSQLPETGALLSELLSRQEFISQQHERAASRAVPLAEAEKVLQATVQNIAQETEQLSNKLNNVASDEAELDEKIERKKREYEQLQKRFAKLQSFRPQYMDEYERFEERLKKLYEVYVLNFRNLSYLRKVHDDLARSERQRQEELEKAMRMAVEKMRLEQEKKDAIGLHDDDGSDAPLVDRRQSVRKVYGNMMGGDASDDDEDDEDDEDDEIIRMDDNVAQHHKRELHRQEEDEERSEADYMVGITTAHVADDAKSDLSSGDDF
The following text describes a protein:
Function:
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MFDKLRSAFSNAAKSFGEKELNEKDIEDILFELEISLLESDVATEVIDSIKDDLKEKLVGSKVDKKEIEKFVKDSLISSISAHFDAAGEIDLFGKINEKKEQGQPFLILFLGINGTGKTTSLAKVAHMLQQEKYSVVVAAADTFRAGAIEQLREHTNRLNLKLVAQNYNSDPAAVARDAVLYAKSHKTDVVLIDTAGRMQTSENLMQQIEKITKVVNPDLKIFVGDSLAGNDTVNQAREFHAHTNFHGSILTKSDADARGGAALSIVKVTSTPVMYVGVGQEYPDLKPFDKKTFLETVFGNLDNVDIKKEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPTPEPEPTSDDPFEGIKDDEIATYSDLFDVPPPENDDEAFKLGKKIRQWIKDGKPEPGDEDEEDEDEYEDDEDEDEEEIQKHDKEEPKKKKGRFGFFRR
The following text describes a protein:
Function:
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MRPTEACCYLKISLIILFYMGCYAQKHPNMDIAVILVGTTDEVAIKDVHEKDDFHHLPVTPRVALVTMNESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKSSCYNIQESRVYEAHMLKRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNQQRKWERVGKYKDRSLKMKYYVWPVFELYPNSEEHKDEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRTENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFFWQLRHCFMGVCSGKPGVVFSISRGIYSCIHGVPIEDRQSAMNSPSATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSFQPEENLFSDYISEVERTFGNLQLKDSNVYQDHFHHHRPHSIGSNSSIDGLYDCDNAPFTTQPRSLSKKPLDIGLPSKHSSTQIGDLYGKFSFKSDRYGAPDDLIRSDVSDISTHTVTYGNIEGNAKRRKQYKDSLKKRPASAKSRREFDEIELAYRRRPRSPDHKRYFRDKEGLRDFYLDQFRTKENNPHWEHVDLTHIYPERAEDFKHETSCANRQHQKHGGEFVQNERKHGPGGNAWEKNMSNVEWEDRTSSNFCRNCPSKMHNYTGQNTNRQACIRCEVCKKAGNLYDISEDNSLQDLDARPIPAANSKYPQSPSNGKAQKRNRSKLHRQHSYDTFVDLQKEDVTLAPRSVSLKDKERFLDGSPYAHMFEMPNETSFTSKSHGPSHNPGGYMLSRSLYPDRVTQNPFIPTFGDDQCLLHGSKPYYFRQPAIGGLKGRADFRGAGKSLSSLHSGPPGHFQKDICIGNQPNACVSNNKNPRSFNNSTNGHVYEKLSSIESDV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
Sequence:
MSALSTVYDLTRPISSGMPVYPGDPPVKITPMLSPPWQVSSLALGSHSGTHLDAPRHRFAHGPGIDDFPPERFIGQGEVIDVRGYPANTPIEPTVLDGYQIWPGMMVFFRTGWDDFWGSDHYFRHPYLSAALANTLVQQQVGLVGIDALSVDSTVDGSDAAHVRLLGAECLIVENLCNLAVLTCGARYTFACLPLKLAGADGAPARVLAWADV
The following text describes a protein:
Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEENAEDTLEFYRHQTGVTVAYTLFYSLVFVIGLLGNTFVVRTVVSNRQFRTTTDYLISSLAVADLLIILFCLPTTLLNNILTEWHLGGIICKMSTWVNSTTSCASIYTLVFVTADRFFAICHTLKYQTWDTHYTLHVIGVIWIASSILASPNLFWYNEVAYNFTTENNTTLTCKLCFSTTDEKTYFVSVNLLIAFCVPFLLISIFYSLIFIRVSTHTSLAVDAQIRDERIKVRVAKMMFLVIIVFAICWIPLYMIYFYFFFIADHTSALFEISSIFLRPFFQWLSLTSSGVNPIIYCLYSQKYRKAALSAFCPNSYEKVRGVSSRETETSKLTRNGTVSTRRHDGVDEWRREESSMGSLVHSPIGTSVL
The following text describes a protein:
Function:
Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER. Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR. Regulates L-AChR sensitivity to agonists such as nicotine and levamisole at neuro-muscular junctions. In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=During the assembly of acetylcholine receptor in muscles, colocalizes with L-AChR component unc-29 in the ER.
Sequence:
MQDEIIDFFRSPALLFYMTLMLTICVVNGSQQVGEVVETEFHAYRLHQYEISGNIYGCKNYRVSYEAVSLGARTLRRTMVTTWRDLLTTDVDDMWALSTGAVLIFIPDNLDELNDIDRKAFIDLEAKLLSAKTDLAVYVAPFNDDAVSILHDVNTRSEKAPTALQHLLQSLSGNTISITSSDQSPELPPSYKPLNIVGRLSSGDRAAPTIAFVAHYDTQSAVPGVSPGADSNGSGIVALLELLAVLSKFYDSPSTRPPYNILFIWTAAGKLNYQGTRHWIDEYQKGFDSADYAKSGLSRKGFSDDRVDLAICIEAIGRKTGGFFMHAGKTPSENSVAAQLLRRLKYFSSISPKKNIELVTKKISLTTVSAWEHEKFNIKRMPAITLSTLPSPSDPARNSILDLPSALDEDELIDNIRLIGEAVLGYILDLPESGPSSDSRVKSEATMLSKDAVDKQRVHHFIRQFASRPRPVGDQRATESITSNLASVAAGYGNVFKSAVTITDAKAFGVTQNRLVAERVKPAVFELVIAAGVFTYLSAFYYIATHSQNTIEGTVAAIRKSIF
The following text describes a protein:
Function:
Involved in the degradation and detoxification of 5-(hydroxymethyl)furfural (HMF) by mediating its oxidation to furan-2,5-dicarboxylate (FDCA), a biobased platform chemical for the production of polymers. Active with a wide range of aromatic and aliphatic primary alcohols and aldehydes: acts on alcohol groups and requires the spontaneous hydration of aldehyde groups for their oxidation. To a lesser extent, is also able to catalyze the oxidation of thiols that are structurally similar to its alcohol substrates, yielding the corresponding thiocarbonyls.
Miscellaneous:
MISCELLANEOUS: At pH 7.0, phenylmethanethiol is oxidized to the corresponding aromatic thioaldehyde, benzothialdehyde, and no formation of 1,2-dibenzyldisulfane is observed, demonstrating that HMFO does not catalyze the formation of disulfide bonds. At pH 8.0, two products are formed, benzothialdehyde and benzaldehyde; this suggests that the thioaldehyde is slowly hydrated, yielding the aldehyde as the final product.
Sequence:
MTDTIFDYVIVGGGTAGSVLANRLSARPENRVLLIEAGIDTPENNIPPEIHDGLRPWLPRLSGDKFFWPNLTIHRAAEHPGITREPQFYEQGRLLGGGSSVNMVVSNRGLPRDYDEWQALGADGWDWQGVLPYFIKTERDADYGDDPLHGNAGPIPIGRVDSRHWSDFTVAATQALEAAGLPNIHDQNARFDDGYFPPAFTLKGEERFSAARGYLDASVRVRPNLSLWTESRVLKLLTTGNAITGVSVLRGRETLQVQAREVILTAGALQSPAILLRTGIGPAADLHALGIPVLADRPGVGRNLWEHSSIGVVAPLTEQARADASTGKAGSRHQLGIRASSGVDPATPSDLFLHIGADPVSGLASAVFWVNKPSSTGWLKLKDADPFSYPDVDFNLLSDPRDLGRLKAGLRLITHYFAAPSLAKYGLALALSRFAAPQPGGPLLNDLLQDEAALERYLRTNVGGVWHASGTARIGRADDSQAVVDKAGRVYGVTGLRVADASIMPTVPTANTNLPTLMLAEKIADAILTQA
The following text describes a protein:
Function:
Functions in dendrite outgrowth and synapse maturation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Synapse. Note=Enriched at the excitatory synapses in mature neurons.
Domain:
The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.
Sequence:
MIWCLRLTILSLILSQGADGRRKPEVVSVVGRAGESAVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQFQETPPLVLEVKELEAVTLRCVALGSPQPYVTWKFRGQDLGKGQGQVQVRNGTLWIRRVERGSAGDYTCQASSTEGSVTHTTQLLVLGPPVIVVPPNNNTVNASQDVSLACRAEAYPANLTYSWFQDRINVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFPHPPSASAYLTVLYPAQVTVMPPETPLPIGMRGVIRCPVRANPPLLFVTWTKDGQALQLDKFPGWSLGPEGSLVIALGNEDALGEYSCTPYNSLGTAGSSPVTRVLLKAPPAFIDQPKEEYFQEVGRDLLIPCSARGDPPPIVSWAKVGRGLQGQAQVDSNNSLILRPLTKEAHGRWECSARNAVAHVTISTNVYVLGTSPHVVTNVSVVPLPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRAHHDWVSLAVPMGATHLLVPGLQAYTQYQFSVLAQNKLGSGPFSEIVLSIPEGLPTTPAVPRLPPTEMPPPLSPPRGLVAVRTPRGVLLHWDPPELIPERLDGYILEGRQGSQGWEILDQGVAGTEIQLLVPGLIKDVLYEFRLVAFADSYVSDPSNIANISTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAACLMNRRRAARRHRKRLRQDPPLIFSPRGRSGPHSAPGSDSPDSVTKFKLQGSPVPSLRQSLLWGEPARPPSPHPDSPLGRGPLPLEPICRGPDGRFVMGPTVAPPQEKLCLERSEPRTSAKRLAQSLDCSSSSPSGVPQPLCITDISPVGQPPAAMPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPTPASPPDFMGSHPCPTSSFLPPPDSPPTNLRAVLPGTLMGVGVSSEPPYTALADWTLRERVLPGLLSAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDMELLETWHPGLASSRAHPELEPELGVKTPEKSCLLNTTHAPGPEARCAALREEFLAFRRRRDATRARLPVCQQSISYPEQATLL
The following text describes a protein:
Function:
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Bacterial flagellum basal body. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEQASILLLSIGEEAAAMVMQQLSREEVVCVSQMMSRLHNIKLDQARQALDDFFQDYREQSGINGASRSYLQAILNKALGSDIAKSVINGIYGDEIRHRMTRLQWVDTPQLVALIDQEHLQLQAVFLAFLPPDVAAAVLAYLDKDRQDDILYRIAKLDDVNRDVVDELDRLIERGVAVLSEHGSKVIGIKQAANIVNRIPGNQQQLLDQLGERDEEVLNELKDEMYEFFILSRQSEATLQRLMDLIPMSDWAIALKGTEPALRQAIYDVLPKRQIQQLQNATQRTGAVPVSRVEHIRKVIMAQVRELAEAGEIQVQLFAEQTME
The following text describes a protein:
Function:
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome.
Sequence:
MAEINRMQYEREYTEGISQSMRVPEKLKVAPSNSGVDPKTQPDMPIPGVFMEVPERIVIAGHSEESLFSRPSNLDFIPGANIAALALKTPPRVLTLSERPLDFLDLEGPAPATPHSKEVRSSGHLKRDGLASENSLRQNGQLVRHDSMPILRCGSSTSVPVTHHDNPRSAMSTLDTTLDSTPDDLALADAASLRRQIIKLNRRLLLLEEENKERVKHEMTMYSIIIIFGLLNSWLWFRR