lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. At the opposite of cultivars Aichi asahi and Sasanishiki, the cultivars Nipponbare, Mokoto and Hitomebore don't recognize the effector avirulence protein AVR-Pia from M.oryzae.
Sequence:
MDAPVSFSLGAMGPLLRKLDSLPVAPEIRLPEPLKDGIELLKEDLEEIGAALVEQSMVDSPSHRARYWMDEVRDLSYHIEDCIDTMFSMRCGGDDGKPRSVRRHKVGRVKVDGFSKTQKPCTRLARIAELRALVREASERHERYQLGDGRASSSSSSSHRVFTAHGQVPAPCRNLVGMDEPKTKLTNMLTDEAELHMKVVCILGSAGIGKTTLAEQVYRKLRWQFDCHAFVRASRKPDMRRLLGAILSQVQLRIRISDTSTVQSLIDNLWEYLQKKRYFIVIDELYETATWDIITSAFPEDNNCSRIMTTAGIEGVALECCSYHSVNIFKMIPLGLDDSAKLFFNRVFGSEQQCPYELNEVSYRITAKCGGLPLAVIIIAGLLASLPCKTELWYNIDGCLCSSVTTDIDLDEILKEIISLGYDNLPHYLKTCLLYLSLYSEGFIIWTADLLKQWISEGFIAVIDGEDIEEVAESYFYNLVNRGMIQSVKTKYNNQVLCTVHHTVFDLIIHKSKEEKFISAIDYSQTMPGNSLEARRLSFHFSNTRYATEVAGITLSQVRSFAFLGLLKCMPSIMEFKLLRVLILEFWGDNHGCMSFNVARICRLFQLRYLKISSQIIIELPAQIRGLKYLETLEIDARVTAIPSDIIHLRSLLHLYFQDGIVLPDGIGCIRSLRTLKYFDLGSNSEENIRSLGQLTNLRDLHLTCSAPKSNQQAKRNLVILASYTGKLGNLKSVKFSPGDSGMDISFLFYGIGISVDRSRTASSLPFSVRTLELPSICIFARLPDWIGQLRKLHTLNLAVRELIENDIDSLAGLPDLIVLSMHIMKAPMERIVFNRKAFPVLKYFKFICGTLRMAFQAGAMANLHRLKLGFNAHKGEKYDNILVGIEHLLNLKKIAVRIGGAAEAKESDRMAAEAALKEAIRKHLMFLDDLDIARVECVKEEYKCIKKKHKIKIEDSISEKNGDSKKQHSVEKKAVWGKTMKNIADSGVFPEDYTMSREQRVAEGFVVGIEKCRAEDAAERIIRNVPVDYDGLGQVSTSKIQDHLPELAPRAVQNEKFGSSNDLSIMIQINKYARLPSYEWRDTDISKLNFRLLRAPMLLEAVTARCHLLDLILIGSNNITVLDLGRPTITKLPASIECLPNLRYLRLQGTQLKSLSEVIVKMPTIRGLDIKNTKTEELPQGILRMKKLSHLSMGEKQKNIQVFMEKMQTLAETVQDSDDLSDETEGIADDEGEFSTRANASTPKVDEDEVDRRANNFIARFRKQITIRNSGFAKKESSIDERLWIRDLDECQLSKRGGRF
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MFLEAAQLTASGRPVLQPGEVEVSLLDKVDVEFNPVGGVAGHQSHAYKNGYAILTNRRVIWVNAGTGATDGAGGGAGDASAPRAACLPLSTLAASNKRVQYGIKGSKVRLVLDVYTNGQRQPVPTWGFHTNIDQVSLRCRGPAPDAFKSLLDEHVQQAVAAGSSSGAAAGSGGAGAGYATGPAAATQPGAAGAAAGAGGAGAGVNSYMSPLTAGLQGRHPPPPPPAGSGAGGGAGAGHVPGAGVSVSGLPPPPPPPQHHLAPQPPAQQAALRPDPALLQNMVEMGFPRNRCARSLLAVKNEGLQEALDYMLAFGDQPGMDDPLEPQPTPASYGTGGAAGGGGGGGWGQQQPQPLYGAGSGGGGAPSMRYPSVMPDGYPPPPPPPTSQPPYPGAAPLNPYGPVPPPPYFPSAYAAAGVSSAPSGSPQHPHGVAGAPAEHLAAAMGSLALARGQTPHHHHGSAPDLSSAAAGEAGRPAIGVAGLMMREQQKTEQSGRAVEQAFKDLSALMASAAAMVALAEKFRGVLAAGAEAGAGGGGAGGEDPLLLDLETQQQLIALGISSPVTRETAGARYHTELSRQLADFLEGPLARCGGMISLPDVYCLFNRARGTELVSPDDLLQAAKVFPKAGVHGLRLRQLTSGVMVIQGPQHSEERVCAKIAELTALPSPSSTASTASAAPPAPPLGPGVTAGDVAVALGGISTVIAAEHLLLAEARGVVVRDDGPEGLRFYRNFFRQDGLEPSTMASYCRAVANGGGGGGGPGAGLAAG
The following text describes a protein:
Function:
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
The following text describes a protein:
Function:
Putative FAD-dependent oxidoreductase.
Sequence:
MNYLYNISESLKKIFNYFSSITRDCEKKRVLIIGCGFGGSQVAKLLDSNFEVTVVERKQTFFNSIASIRAIVEPELAKKIYIPYDKLLKNGKFIYGTVIEISPTLVKLEDGKELTFDYLVIATGSNSLAPFKAPLEKISGTEIFNYYKDISEQIKQAKSILIVGGGSVGCEVVGEIINKYPIKNKELAKKITIVHSGNKLVSSKTNNKFNNLINESMKKRNVSVILNDRIEIPDDIKQCFINQTSPNFQVSLKTYKTKNGLSIESDFVIWTIGIKLNSESYKTNFSNEINEIGQIKVNQSCQVQGYDNIFAIGDITDFDELKTTYNALSHGNIVAKVIKDLSNGKNKNQLAKHKLLPPIISLSLGPKDGLTQINSNLNFGSFISRILKSNNLLINRFQTHFNNPEPLK
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MTTMVKKNDVPIDVTWEDQRNICVFSRLHRRAQTLNRRLKLLRDDIEKLDDASTEAMICDEVKYVFGEAFVDVECDQAVDLLDEEKQRIESEKEEVEAELKDLDVTLTELKAQLYAKFGSQIYLEEK
The following text describes a protein:
Function:
Cell wall peptidoglycan (PG) DD-endopeptidase, which may act as a substitute for other zinc-dependent PG endopeptidases (ShyA and ShyC) during zinc starvation. Hydrolyzes peptide cross-links which covalently connect adjacent PG strands probably to allow insertion of new glycans and thus cell wall expansion. Degrades purified whole PG sacculi in vitro. It is unclear how it is able to function in low zinc environments, but that may possibly be due to binding zinc with very high affinity, utilizing an alternative metal cofactor or that it may function independently of a bound metal cofactor.
Subcellular Localization:
Periplasm.
Sequence:
MGQFRFLALIVAVLCFSVALFLPTADEPDQDSYSVPLNQSVNTSQPPSSEMVPSDIRLTPLPQPKRIHYMVKVGDTLSGIFAQLGVPYSILQKILSVDLDHLQLDMIQPGEELELMMDDMGQLSRLIYHMSIVEKAIYTRENDGSFSYDFQEISGEWREILFSGEINGSFSVSARRVGLTSSQVANITQVMKDKIDFSRSLRAGDRFDILVKQQYLGEHNTGNSEIKAISFKLAKGDVSAFLAEDGRFYDRAGNSLERAFNRYPVDKAYRQITSGFNPKRKHPVTGRVVPHNGTDFATPIGAPVYSTGDGKVIVVRKHPYAGNYLVIEHNSVYKTRYLHLDKILVKKGQLVKRGQKIALAGATGRLTGPHLHFEVLVRNRPVDAMKADLPIAKSLSSNQKTSFLARVSEFDHLVQANQQEVALDET
The following text describes a protein:
Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Subcellular Localization:
Cytoplasm.
Sequence:
MEFIRIDGSYGEGGGSLLRYAIALSSVTMKPVEIYNIRVKRANPGLRPQHLNAVRALARITEATVEGDEVGSTALRFIPRKRAGGSFEIDIGTAGSISLIIQAILPACISSEEEISLRIRGGTDVPLAPPIDYMAEVFLRNMAPLGVRAELKLLRRGHYPRGGGIVELHASPSKLFPIDKVRGEKFDRVLGRCHAVKLPRSVVERISSSAIDTLRKEGLRVEIEEEWSEDGHLGPGAGIVLWTDSNPRIGADELGEKGKPSEVVGKNAASKLLDEIKAGMAFDSHMGDMIIPYLALARGRSRVGISKLTLHAESNIWLVERFLPVKFIVQGGVGSPTVIEVEGAGLEL
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MSKDQIKIRKYFYRDRKGILDNKRTISELSIRKGKVNLDRRNARYLVEENIREDANYDLKVGLREYYEESDSDEEPEEVVNGVEEAETTCCTFCAWACSQPQKSLKAVSWRKNDYGNPPYPVLPMNATRRACLMTTVFGGADFVTYRTLIRDIAKTIITHRPYRPNEEKQKPIQCDSLDEVVFHSIYRNKYIKPWAGIAMKAGDVIIIREDDESPFLDDCEEYSEDEEEDEEDEEDKEEEEEEKKEMTDGERLVTNLNEMKRNEIRQRAYSGFKFQQYMTSEEPEGKATPEKRLRIRSFLVNEPIELKSTFAEGFCSKIHTFLHCNFGNMETFVTGQRDENYITTRAFERKTSHLKNDFTGYEGDSQADEQCFSFLYDVLSMTKQVLSRAKACRFVYMPKSGIIQFEPITIKEARKRGHDFPEEFKSRFDVYYS
The following text describes a protein:
Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MGPKESLRLLLVVLAVTFAESQRSDFGNGAEVGTPDSRNCQGTNCGNNCGGCPGQPGPRGFPGSRGAPGFPGPEGIQGETGTAGQPGFPGDMGPKGDRGDVGPIGPQGVLGPAGPAGPRGTQGEKGLKGTNGSPGLRGEKGLRGSQGVPGMPGDQGNPGDNGPMGMPGLCGPKGEPGSPGAPGRSAGASPGPPGRLGPQGPPGPPGVPGPPGAPPSIGVKGEPGLPGTPGLDGNPGRLGPPGTPGVNGIPGGPGPKGSYHKGDIGGPGFTGPPGQQGQRGVIGFPGKKGEPGTTRGIPGPPGNLGPQGPPGAPGFPGPKGDPGAAGPPGLPGRPSAGQPGNPGPPGPTGPRGTPGGPGFPGQKGEAGVGFPGTPGTRGATGPPGPAGPAGITEGTAGSFHLLVRHSQTINIPQCPLGTTVMWQGYSLLHGEGNERAHGQDMGTAGSCLQRFAPMPFMFCDINFHCHYATRDDKTYWLSTVTTEQEIPESTVDGPSILPFISRCIVCEVPSTVMAFHSQSSQVPGCPAPTSEHSWISIWEGFSFFMHTAAGEGSGQVFSSPGSCLEKFRPATFIECHGAQRTCGFFANKFSFWLTTLPGEYDPLRNGQAYEPRDGEVNSLVSGQSQPTTEMERMIGRCRVCMMVTPAIRARIDRARQQG
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
Sequence:
MLLSDKDIRAEIDNGRVRIDPFDDSMVQPSSIDVRLDRYFRVFENHRYPHIDPSVEQVDLTRLVEPEGDEPFILHPGEFVLASTYEVVSLPDDLASRLEGKSSLGRLGLVTHSTAGFIDPGFSGHVTLELSNLATLPIKLWPGMKIGQLCLFRLTSPAEHPYGSERYGSRYQGQRGPTASRSFLNFHRTQV
The following text describes a protein:
Function:
May act as a negative regulator of osteoclast differentiation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEKRALVTAISLSMSLLALMLLVTAIFTDHWYETDTRRHKENCDQYGSESNDQKNREMPIYHLPLVDSGNAKRNLALMKPIHVGSREEELLENWRAILGMGILETECGRPLFSTYSGLWRKCYFQGMDRDIDKLILKGIAERCTSVKYHFSQPIRLRNIPLNLTRTIQQDEWHLLHLRRITAGFLGMAAAVMLCGSIVAAVGFFWEESLTQHVSGLLFLMAGIFCTISLCTYAASVSYDLSRNPPFIYGLPSDVDHGYGWSIFCAWVSLGLTVASGCICTTYPFLSRTKALRSKTARESSV
The following text describes a protein:
Function:
Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
Sequence:
MTRYTTTDVLICGAGVTGLTLAIELARHGVSFRLIEKRTTPFIGSRGKGIQPRTQEIFEDLGILNKVVAAGGLYPRLRTYRHDGSYVDSDIAHHTKPTHAEPYHLPLMVPQNVTETIMREQLKAWGHRVEFGCELRHFAQTPRTVTAYVAGPAGEEVIIAHYLIGADGGGSFVRKKLGVSFPGRTLGIHALVADASLSGLNRDVWHHFNDGDMARMITICPLAGTQLFQIQALLAPDDSQNFSADVLTAFLTERIGRTDVRIHSIPWVSKYQMNARIAEHYRVGKVFLAGDAAHVHPPTGGQGLNTSIQDAYNLGWKMAASLRGAGEELLDSYEQERRPIAESLLHLSTRLLDSQKQRGIKRERDVQQLDIQYTNSPLAHTLPERQHGLQAGERAPDAPLLGAGGQSLRLFQLLQGPDWNLLAYETHGKVIDARRGLRIHHIGEQDELIDTLGHFRESYHLAPGQCVLIRPDGYVGAFFHGKQSNDIENYLSRFAIGIKDEY
The following text describes a protein:
Function:
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MLRPFLKCCVCGRPSIILQIANYRPPPLHEVVARRIEKHQKLGKYFEDNKTYVDETSYFKSNLTEKDKFRLKRRTWAKLGSASNIDPASLFPSKEEVEAEMRAEEEWWPTLNQMKENLRIQKEKKEAKSLERSKKIAQNMAKMPMWIKQFQEEQVATRKKEQEMEKQRGIRLQKVQEKFGFEISRRHPQFVEYMDNQKIQEKSKKKQQIKSQKQSEKKV
The following text describes a protein:
Function:
Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MPQQQQQRRMFTAALLALVFILAAVSTTEAGKKEKPEKKAKKSDCGEWQWSVCVPTNGDCGLGTREGTRTGAECKQTTKTQKCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGNLKRALHNADCQKTVTISKPCGKLTKPKPQESKKKKKEGKKQEKMLD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MGMASSNEIRAPLKPPMSFMLPHDIFHGPKPAHEWYEHMDNHDYDDNDEEEEEEEEVGYCHFHNDYCYHNDGDGDGDEDYDDGYDEDDEDDEEDDDDDDDDDDDDDSVFSLLVQDEIDQHEFESFTSDHYYTPSLDGHDQDPTVDQDDDQDPTLYLDGDYDEGYLTVPLSPPRSVLYFDCNMCMKVAREPVVTSCGHLYCWPCLYSWLNIYSAHRECLVCKSKVFDSLITPIYNCRDINSGFKVPPRPEPKGLRLS
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MRLTGGSRGLSGLHSNVNITLKQIEATVPKFAVDKGQIQVLYDPEEFYDQLKQKILAAKERVFLSTLYVGKEETELVSCLDEALTKNPGLKVSVLIDGLRGTREEPETCSASLLASLLHKHGDRVDIRCYITPHLFGLKKQLIPKRFNEGWGLQHMKLYGCDDDIILSGANLSRDYFTNRQDRYFVFKSRPIVDYYHAIHNAVCRLSWRVALPKPAEKAPEPGKMAVFFKKQAASIAKKILPEPEPVKDPGFVLEWPNNNTLQSPNVSLAEFQRQATASIAPLITSKPVESGRRKVKSLAQRETELEEAKNESESTEPQTLVFPISQFTPLLKPDSSTEFPTLGRLLSMLSMQRSSWTFTAGYFNMHPEFKAKLLGSVPDKGTVITASPQANGFYKSHGISQYLPDCYTLLARQFILDVNKAHRQKEIELLEWQRGVVNTPGGWSYHAKGIWINGPGDKLPSITVVGSSNYTRRGYSKDLETNALIVTTDEELKRQLQQEIDHIERYTTKKSITDYDQEDRQVKTWVKVVAYFIGDKL
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MTRILVLYFTRGGHTAKIANAIAEQLTLRGAKVDLVDINSAAATRINWSDYQLVALGACVLYGTYDKSVFQFIEQHVQALSFLPNSFFCVNVVARNPEKRIPENNKYLQKFITLSPWTPADLKIIAGKVDYPSWPWYDRLMIQLIMKITKGPTDPKAVIDYTDWEDVKVYADHLLTLVEVAEPA
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MYCSMCSSRDGGRHLSLAELLWCCHLVHCLLIRELGFQRETGKGSSSISSDVSSSTDHTPTKAQKNAATSEDSDLSMRTLSTPSPALIFPPTSPGFQNGRGSSTSSSSVTGETVAMVHSPPPTRLTHPLIRLAAKQQKEQAHVDRLPDQSMIHIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRITDEGLRYLMIYCTSIKELSVSDCRFVSDFGMREIAKLESRLRYLSIAHCGRITDVGIRYIAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLEFLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCDVSVDALRFVKRHCKRCIIEHTNPAFF
The following text describes a protein:
Function:
Plays an important role in the regulation of the production of the virulence factor exotoxin A (toxA), via positive regulation of the transcription of the toxA gene. Acts by binding directly to the toxA promoter region. Besides toxA, PtxR modulates the expression of genes that code for the QS-controlled virulence factors. It negatively regulates the expression of the rhamnolipid and pyocyanine genes, through the autoinducer synthase RhlI, and the PQS synthesis operon pqsABCDE, while it positively regulates the expression of lasB through the autoinducer synthase LasI. Also positively regulates the expression of the exotoxin A regulatory protein (toxR or regA); In addition, is involved in the positive regulation of glucose metabolism via the regulation of the expression of the kgu and gad operons. Acts by binding directly to the promoter region of the kgu and gad operons.
Sequence:
MSAALERLNHLNLNHLYAFVAVAEHNSFTAAAEALGLSKSLLSEQLRRLEADLGIQLLTRTTRRMTLTDRGELLFGVAQRMLGELDGALSDVRDLQGEPSGRLRITAPQDFVKWHISSVSAAFIRQFPKVQVEMLADDQFSDLVGQRIDLAVRIGWPRDSGLHASKLCDFQQVAVATPGYLAGLPPVLQPHDLARCEWIGHTRLSTPWTWTFERQRERATVQTRGRLLANNTLAVYRLVLDGAGVSVLPSFLVAREIARGRLVRLLPGWRLPQGGIYALYPSARYMPVRVRAFIESLREHLGREPFRLAQSE
The following text describes a protein:
Function:
Phosphorylates PPP1C, phosphorylase b and CFTR.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPGPLGALRPPTPRPLLLLLLLLPGARAAPLPQTGAGEAAAAEVSLLFVVLSICSLLTLVVLIVNCVSCCKDREIDFKEFEDNFDDEIDFTPPAEDTPSLQSPAEVFTLSVPNISLPVSSQFHPSSEGLKSQVARQSLNYIQEIGNGWFGKVLLGEIYTGTSVARVVVKELKASASTKEQDKFLKNGEPYYILQHPNILQCVGRCVEAIPYLLVFELCDMGDLKTYLCSEQEHIKGDSQIMLLQRMACEIAAGLAIMHKHHFVHSDLALRNCFLTSDLNVKIGDYELGLGKYKADYIETEDKKLIPLRWTAPELVTSFQERLLTADQTKFSNIWSLGVTLWELFDHGAQPYAHLSDVEVLQQVIKERDTKLPKPQLEQPYSERWYEVLQFCWLPPDKRPTAEEVHRLLTYLRMQSQRDSEIDFEQQWNALKPNTNNRETSNNAAFPILDHFTRDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERNQVNPDEAMSYTSIFFPVDVFESSLSDPGPGKQDESGQDVSLRAPGVVPVFDAHNLSVGSDYYIQLEEKSGGSLDLDNQSAVLTTEVDNPETLTDHSSQFVALRDLDDGESNTDGDFFHYTGDPQDIGIPEDSHVVSVPESPFSNIFNELDKSEDLHSHQKIFDLTELNGIHAEFKPATLSPTLDVPKETLVTGHLEKKNVHNIFDHDAICLSESLVHQNDFDPLNVQELSENFLFLQEKNLIKDTLSRKEHACDLQTELEKAGFTGNVLETSHRNSLDIELNFIENKSTSTLLQDSTKAESKEECIMPVRENLSISLQSSPELQITSNSPKTEEKACAVHPEFNLFQEEAKPPCLDVVTCDVSPQKEINPGTKTALIEVLSSDAVAQNIEGESHDISPQSKESTDITKSKALHFDEETDCNMGTKEGNQDLENKSSLRDHNDRNLLEKEHETLGISNQLTYKEAPKEVGLISALSSDSTSQDSLLEDSLSTPIQTSEQSVETPDSLDSLDVHGVLDSLGTQSPQKLVPPDKPADSGYETENLESPEWTSHATVDDTSNTDATLINDGTLTALPPNPVIVISDEADSNKDFDLTSKTLVGSIQNSYRDSAYFSDNDSETDKKSEDVTGTSAALALFTKDQPQRGLSSTEQSFNAKQGCHKERANQSPLSGLQNTNEPELQSILDPEQTGTPRQVDAAELEAENHLTLIPSSECNYSEEFDILDDHCCNRTSTGTNTDELLAYTNATFGSGSPSAMAGASFSTDLMGDKALSYSEGPKLKEPDIEGKYLGKLGVSGMIDISEDGIDADEEDENSDDSDDDLRAFHLHSLSSESEDETVHPVPVILSDNDNGKHLRSLLKLPTSVGSDKPPDNWRKDKKAVTFFDDVTVYLFDQETPTKELGHRGAEANNPESNSPTPLLGPNYLSRFTNSESSTDEEGGGFEWDDDFSQESFMSKTADNLGSKPSLQTSKYFSPPPPSRSIEQSWSHSSPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD
The following text describes a protein:
Function:
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
Subcellular Localization:
Periplasm. Bacterial flagellum basal body.
Sequence:
MKRVFLWLIFVLAFHKLLAEKIGDIASVVGVRDNQLIGYGLVIGLNGTGDKSGSKFTMQSISNMLESVNVKISADDIKSKNVAAVMITASLPPFARQGDKIDIHISSIGDAKSIQGGTLVMTPLNAVDGNIYALAQGAIVSGNSNNLLSANIINGATIEREVSYDLFHKNAMTLSLKNPNFKNAIQVQNTLNKVFGNKVAIALDPKTIQITRPERFSMVEFLALVQEIPINYSAKNKIIVDEKSGTIVSGVDIMVHPVVVTSQDITLKITKDPLNDSKNTQDLDNNMSLDTAHNTLSSNGKNITIAGVVKALQKIGVSAKGMVSILQALKKSGAISAEMEIL
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEFQAVILAAGPGSRMYPLTENMPKALLPVANKPMIWYPIRILQKAGFEEIFIIVLKSQSDVIKKSLVSCNLKCRLHYVQISDEEEVIGTAESLRKIRDKVKNDLMILSCDLITNLELHRLANIHRIRDSDLTAFMYTRDDSSNEAEGKNKKKKKKEATSQCDFVGVSEKDSRLVFLSTAVDVHKDLAIKRNLFMKYPRVLLRTDLIDAHLYLVKKWILDFLIENKSYNSFKGEVLPHLVYKLDARPEVASVDTEQGKEDNTRNNLGTTSKSEIELEQLALSLSTCYRGENIEEGYEASKCYTYISDKNNCIRVNSVQLYMDANRHALRWISSFLPEATDTKSVHFSANTSQRARGNISEVGDAKTGYTTGTSTSKTRGSNTSETGESKAAYQSGPSAPTSKSGTNNAIVESADAKTNTAVERKVGVDQESIIGDGVTIENKCAIKKSVIGNHCRILDNVKILNSVLMDHVTVESGCVIQNSVVCSLAHIKGRCTIKDCQIGYSHTVSDATEANGECLVSAEGGMMTLDNAN
The following text describes a protein:
Function:
Membrane-anchored myosin receptors that define a distinct, plant-specific transport vesicle compartment.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein.
Domain:
The GTD-binding domain is sufficient for myosin binding.
Sequence:
MDLAIVSSPTRDVVRCCDCGCDCSLNGASPGSLLRSVKRKYEEFENEKLFHIPELELDLSSNAKVQIENELELLRETVSSQQQSIQDLYEELDEERNAASTAASEAMSMILRLQRDKAELQMELRQFKRFAEEKMEHDQQELLDLEDLIYKREQTIQALTFEAQAYKHRMMSFGFTEAEVETEKNMLSRNPSMIENDYQYDLPTSDYPPIKCNVNENPGPLEADIDVDDVEKYPLADSPHPLKTLERRISQMERNPSFTQPTGDVSGGRHYTEKNVVGQSPRHQRHFRRVSTGSASSLLGTTREKRLDFSNDSPRSNNGSFRKMEDPPYAAGNSFARDKGDSSEIGDNDMNDRVYTIDSVHHSVSHSGTAEQKFKNDTADGYAMSPREISNQPDLGDPEISKLYMRLQALEADRESMRQAIMSMRTEKAQMVLLKEIAQHLSKDVVPERRLPLRKTSIIGAFNFISVFKWITSFVFWRRKARRSKYMNGVQGNNMGLQMLLEKTPRIRQWRCLSSTQV
The following text describes a protein:
Function:
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAQPEGVLAWNPAFRPEDNDSVATDLARLALDSGKEVSETTDVDTHVSPPAEEFTDENGSIESKTAISADTSDQGAPDLVDSNTPAADNGSKPDTEEPDKPSRDESIFMQTDKSRAVEDVTENVPTENGNVDITSGLEEHVAEEPHYEGPEKSTGLAGRNDAQDLFEGNDTAWMDEAEGEVNGATVNGEASGTRPGFWDSLGDNERDNEDDFFNQLKTQTKPIYSPPETEARFEEGIPLLGQGAAPQNNHAHKGESQVDDVFGDDEDDESGFFSEIQKRTSAEGPPPITRKSTSQVIDSINAVSDSMFSKQLPAAAELNNSLAVPTADGEIKNSPSEEDLAARWQAELSDDADETMPTEDDLAARWQAELDDDDDDLLLDDDTTNAQRPPEAANIDHMNDTSMLQSPFGTPENLARPKVQPVSYTPHQPSTSDLLSGIPAQNTAAQPTNASMSSYFSAQAPPNPVTTRAESFAERSKEGYKSPYDIPEDLARPRRAVANSRTVVAQPGTVPKPPPRSSSIPAPPLKASTVSPAPLGTSSTAPTAPQKNFFEELPLPPPRPKSRPASSGRYTPNAPVSAPSLPQSIPPPANQYSNVPGAPQSNIGPPDPPQLQQPERLDPYSNLLAPNVPSAPAVPSTASRYSPRPPGVQAGVKPPPSPRYSPAPPQSTNAVAAAPRNRYASQPASISGQGAALQFQPRTSSPLAYHEKIHYEDQGQSEERPQLQSTASPPPLNHSHPSEQPVSSENKGPSGVDVLENVPPLSTRPQSPPKNPYAPSAYTNEFANRVAPVSTGPPIAGMTGVLNSSTEESPFVPPRRSQTQSPSQTLSPRLSVPSLDPFQRPASVHGSTSPTRTVNPYAPAPVPTHNRAPSQVLEFIPPTDGQQLDSLERWKGAPIFKFGFGGAVISCFPKHIPRYSAGQAAPMIKSCPGEVRISQLNDWLPAAEGIVQHPGPLKGKSKKKDLVAWLSSKIAAFENADIPDFDRLSPDASKLREEKTLLWKVIRVLVENDGVLEGSVEAQKSLRNLLFPNLQDSGPNQSLGDVFTPSATLQPLNAPSQPDAVDSRSVDLLRDTLVLGEREKAVWAAVDKRLWGHAMIIASRMDRSVWQQVVQEFVRREVRSATSRTESLAAFYEILAGNIEESIDELVPPSARAGLQMISKVDGHGPAKNSLDGLDSWRETVGLVLSNRSPDDQRALVALGRLLLSYNRTEAAHICFILSRVAVFGGLDDPQANIVLLGVDHQRLSSCAALYNDDSILLTEAYEFATSVLAGSSVSTLPHLLAFKLIHAWSLAERGRKSEAQQYCDAIAAALKATTKPSGYHNQHLFFGVDELSARLRETTSDGGSSWISRPSMEKVSGSMWAKFNSFVAGDDSDAASTGSVKAEEIGPFARVSGTPTISRSPSVSDIYGSYPVAAAQPLPATGPSRYQPVSQYAPSASPEQLRGRSSMDSQRSASFGYPLGQRRGSQEPSTPVDTNMFHGMPMYGSPPVAGYQSTPPQSSYMPLAPVAEDSASGAQQESFSAHSQVSDNAPSHRSSTYAPEPFGHPFDTQAVSTTSQPDQGGYMPPTSSGAYEPPSFESNTESADGAQDESTEEDKPKKKSIMDEDDDEDLAARAAAIQKAERARRDREADEAFRKAAEADAKKPPPATGKKGWFSGWFGGKKDDNSGGGPIRAKLGEENSFYYDTELKKWVNKKDPGSAAPTRGTPPPPKGSAPPSRSMSGSGGPPPAMATPPPTGASGSRPSSSAGAPTSVSASPAPPSLGAPPPAIPRSVSTGAVLPTPPSSSAGAPPRPATSLSNASSIDDLLGAPQARKGPAARGKKKGRYVDVMAK
The following text describes a protein:
Function:
Putative transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSSVKTPALEELVPGSEEKPKGRSPLSWGSLFGHRSEKIVFAKSDGGTDENVLTVTITETTVIESDLGVWSSRALLYLTLWFFFSFCTLFLNKYILSLLGGEPSMLGAVQMLSTTVIGCVKTLVPCCLYQHKARLSYPPNFLMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGRPSDREEREELQLQPGRGAAASDRRSPVPPSERHGVRPHGENLPGDFQVPQALHRVALSMALPCPMLPAS
The following text describes a protein:
Function:
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes.
Sequence:
MGRGPPAGPGGARLPSGVAAAGGGHSQGSIGGSASRAGGSAAAAAAAIAAAHGPAPPLPPPLARAAPVSQPPAAPATRPAMSLSGASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPDFLGQAFLALGEVIGGQGSRVERPLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPLNNNDEDPNCAGIDGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKISDGSQYYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEEQWKNWMVMMCACPLGDAMQSGTSFSSSHSETMSTGRETRC