lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane.
Sequence:
MIGLFKDEWFNISILNDNLFLKRYCYESNNNNNNNNTLYTIIVPFDKSINPSQFDPSTINDYFIFLYKNTKKINLNSINKLQYKSNKKEILVSFDITYIHNSNNNNNNNNNKLKSVLISNSCSKKLNLFNNDIVHLKPIKKKLTVLQRVVLLANDNESFIESSNPSESSSSTTTINSKYLVNEEFRNYLVENSILFQSPNNIVIENHQKHKSFSYKVLECFPLLQGTVSNSTTIIIISPDDKILNTLPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKEEEVEEEEVEVEEEEKDNKLKLNNNLRLSNFIIHPIINISNNTTTKNEDIGDSNNLFHFTPSSKGILSNNKKFINISQLKSIPTEIDFEFDISKEYDYLVDCLVSLNTLKSLNLFNGSWIKIKNITNNNNNNNNKEYEIAIRIFSITSSLKLKDQVLYLPPISIFNLNIDYKNFLKLSNYEIISNQFELILLKSNKPNINNNNNNDSFPINYPTANRIKISRIKNQNSSGYKSYSHQLEKYFQKKRLLKQNDIIVISTKVNNEEELINSNNSNNNNNYNNNNNNNNNNNLVYFKVEIILCNQFENINGNQIYLIDKNTTSIIQEGSSNSMVPSKIESFYWRGGDQEESKDNSMVPLELIYENEFKTIVDLISPFLMGDKFSFDFNCTLLLNGPQGVGKRTLLNRVAKQMGIHVYEVDCYKLYDFVESKKDWNIRNVLEQASNSTPTLLILKNFEVLEQTAQSMQQEKKESNLSQTLINILKDINDSNTSNINSNKYPLIITVTVNSMDELSNKVRNWFKHEITLNSPDENQRFKILKYLTKNLPIDIGNTVSIKNLSIRTASFLNSNLRALIQRSSINALKRVLSIQQMMNDEIKPIEIYNCGFLVMGDDIQKSLSEMQEYQSSSIGAPKIPNVSWDDVGGLANVKSEIMDTIQLPLEHPHLFASGIGKRSGILLFGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEKNIREIFNKARQAKPCVIFFDELDSLAPSRGNGADSGGVMDRVVSQLLAELDGMQKSSDVFIIGATNRPDLLDSSLMRPGRLDRLLYLGISSEKENQFKILQALTRKFNLADDVDLRKVVENCPMNLTGADFYALASDAMSNAFHERITASINGEINEEEQNQKLIVYQNHFIKAVNSLVPSVSLDELEYYHKVQKQFSGNNKS
The following text describes a protein:
Function:
Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Sequence:
MSTASNRVSTQIVDEHKQFNNELPKFMQSVGLLDAGFNYHVVAVLGSQSTGKSTLLNNLFGTSFSVMDASKRQQTTKGIWLSKANNSPILVMDVEGTDGRERGEDQDFERKSALFSISTSEVIIVNMWENQVGLYQGSNMALLKTVLEVNLQLFHNKKERCLLQFVIRDFLGNTSMENLADTIMTDLNNIWASLSKPEGFENSVINDFFDVGFTGLPHKILCSDAFSEAVDSLRERFVDNNNSDYIFNVSYHKKIPADGFSLYTREIWDTIENNKDLDLPTQQQLLAQYRCDEIITEVMEPFSTACTILQKEFLPGNLCKDLPTKLLNMFETVIEAYDRQASRYNVHIYQKKKQELIASVDSHLYVFFQAQLNALHKELIKSFFDASNEFPSDTPFKESSSIKINELVNKMREEGESLSLPHVHWDVDPFILKLSEELTQNSETLCKEKLKEKLEELFTGFEFEVSEAVEVAFQKLSHNVWDTLLNEFLAAQNTTIEKIKNIVPFYVDIDDTKTTEEYIINFKKNSWLFFRKKIDSEMSEVLLQQRLRVYFEELFRYDSDGMPKLWKKSGTIDRDYRESLTKTLDLINVLASIKVSDGNYPDLNVDIKTLEPEYTSPASFFTILNRRRVSDISVNFKRSADLIFMDCKRSVINTTTRIPPYFWVLLIVLGWNEFMAILRNPFVFMILMFGGTVVYGLYISGLIWPAKMVLERATNNLVDLATDRFSNTYQEQVQQRAMQRTEKSGSPVASADDAEAEKTALS
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
METAGHHNISTSEDDYKKKRGSCNNNITTNNNHIKKGSLNNGGSSTTQRCCQAEKCSADLSDAKQYHRRHKVCEYHAKAQVVVVAGFRQRFCQQCSRFHELTEFDESKRSCRRRLAGHNERRRKSSSSTAESHNIAESSSRKGTVQLNNKDINMICGQVNDKGRIQISIQENSTFKNFHLR
The following text describes a protein:
Function:
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Sequence:
MGITKLADLIRAEAPDSISHRDISDYAGKVIALDTSVVVNQFRAATPLSSPLRGLFFRTLTFLEHDIKPVFVFDGKPPVEKLPLVRRTRGTLVSWVPAECRCSHLGVPVVQAPGDAEGLCASLVREGRAHAVASEDMDTLPFGANVLIRQLNAKKDSEIVEYSLPKLLEALRISLEELVDLCILLGCDYCDKIPGLGPKRALALIQKHRTIENVLLNINRETHPVPHLWKFKESRQIFLDPPGPPTPELVWTEPDEEALVKFLRPIMKEERVRHRMETFREKRRDLREEREKEKAAGHCRQTRMVDFFRITRKRNQNEHVSVRGRKQFN
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MAGAGLIGIRRRIKSVTNIRKITKAMGLVSTAKLRKARVNLEINKKYYNEYKIILKDIINFIEDSNIYIDGNGSHKKLYVIFTSDSGLCGSFNINIINNVINEIKEDKENSLVIVIGQKGRMYLKKLGINTLAEYIEIPDVPTTKEAGTIAKNIIKLYSSKEVGEVFLVYSEFYSPVKQQVLINKILPFTKENKSDNKYIEFNPPVTQLMDEILENYLKATILNCFSNSKASENGSRMTAMNGATDNANDLLDNLDLQFNRLRQSAITQEISEIVGGAEAQR
The following text describes a protein:
Function:
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton.
Subcellular Localization:
Cytoplasm, cytosol. Membrane.
Sequence:
MYFLSGWPKRLLCPLGSPAEEPFHVQSDPQRAFFAVLAAARLSIWYSRPSVLIVTYKEPAKSSTQFGSYKQAEWRPDSTMIAVSTANGYILFFHITSTRGDKYLYEPVYPKGSPQMKGTPHFKEEQCAPALNLEMRKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRVGSFLGFTDVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCVSGSVQVYTIDNSTGAMLLSHKLELTAKQYPDIWNKTGAVKLMRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTEIESDLRSVVKQPSILLFQFIKSVLTVNPCMSNQEQVLLQGEDRLYLNCGEASQTQNPRSSSTHSEHKPSREKSPFADGGLESQGLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFMVLACYNINDRQEELRVYLRTSNLDNAFAHVTKAQAETLLLSVFQDMVIVFRADCSICLYSIERKSDGPNTTAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARGAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNQRKLLPFCPPVVLAQSVESVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYTRNNAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTTQEPSSSGGFEFFRNRSISLSQSAENVPPSKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEDVRLKDLGCFAAQLGFELISWLCKERTRAARVDNFVIALKRLHKDFLWPLPIIPASSISSPFKNGKYRTVGEQLLKSQSADPFLNLEMDAGISNIQRSQSWLTNIGPTHHEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGEWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVITQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPQLQKLSEITEEQVQPDAFQPVTVGKTPEQTSPRAEESRGSSSHGSIPQGEAGSSSMVSRKEEDTAQAEEEEPFQDGTYDCSVS
The following text describes a protein:
Function:
A humoral factor that may play a role in stress tolerance.
Subcellular Localization:
Secreted.
Sequence:
MSYNRTLHSTTSILKMNSALQISCLLLVLGCLLGSGHGQSDAEFAAKSREISQIFGNPSVDKYTKVRNLPALVAFYEKYSSRLRLTAQEKKGIDNAIRQYRAQQNQKVDGVSAQGGTLFDILKKVVEVIIKVVV
The following text describes a protein:
Function:
Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity).
Sequence:
MYPRSRVVGPGLGTSSSSRDHAGAGQHGELDLQQNQRQNLEVAEPKGPKLERQGHGDQRSTGTYTLIAPNETRRQKIQRIAEQELADLERWKQQNKAKPVHLVPQRLGGSQSEAEVRQKQQLQQMRSKYQQKLKRDEAIRIRKDAEEAELQRMKAIQREKSNKLEKKKQLQEDIRRATLREHHQSKTAELLSRLDTDRTNRSACNIAPPAAQSSRWKLPVLLRDPSRAGSQAHKDSPQKEDNQKLQKTRDGHQKNKLLETKGQHQEEERAQIHQAEHWRVNNAFLDRLQGKSQPGGVEQSGGCWNMNSTDGWGI
The following text describes a protein:
Function:
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity). Is involved in NF-kappa-B dependent negative regulation of inflammatory response.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.
Domain:
The N-terminal region is required for cytoplasmic localization; The ANK repeats and the SH3 domain are required for specific interactions with p53/TP53.
Sequence:
MDSEAFQHARDLLDLNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGAQAGVPSRMARYSTSPVPEHFGSRGSPQKIATDGIEARFGRSESAPSLHPYSPLSPKGRPSSPRTPIYLQPDTYSSLDRAPSPRPRAFDGAGSPHGRAPSPRPGIGPVRQPGPSTPFDYLGRAGSPRGSPLAEGPQAFFPERGPSPRPPAAAYDTAGTFGSPLLGAGGSAFTPPLRAQDDSTLRRRPPKAWNESDLDVAYEKKSSQTASYERLDVFTRPASPGLQLLPWRESSLDGLGASGKDHLTSATLPRNYKVSPLASDRRSDVGSYRRSLGSAGPSGTLPRSWQPVSRIPMPPSSPQPRSTPRQRPIPLSMIFKLQNAFWEHGAGRAVLPGSPIFSRAPPPKLPPQPPPQPQMQPQPQPQPQMQPQSQAQPQTPAPQQTWSPMNEGLLKSPAELEPEPELEVLLAPVEEAGDADEGTVTRPLSPTRLQPALPPEAQTVPELEEVARVLAEIPRPLKRRGSMEQSPAVALPPTHKKQYQQIINRLFHRHGGPGPGGPEPELSTITEGSEARAGPPAPAPPAPIPPPAPPQSSPPEQPQSMEMRSVLRKVGSPRKARRARLNPLVLLLDAALTGELDVVQQAVKEMNDPSQPNEEGITALHNAICGANYPIVDFLIAAGANVNSPDSHGWTPLHCAASCNDTAICTALVQHGAAIFATTLSDGATAIEKCDPYREGYADCATYLADVEQSMGLMHNGVVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWASLHGQEGYVPRNYFGLFPRVKSQRSKI
The following text describes a protein:
Function:
Converts glutamine and N-terminal glutamyl residues in peptides to 5-oxoproline and 5-oxoproline residues. Not involved in the major pathway for 5-oxoproline production.
Miscellaneous:
MISCELLANEOUS: Has a low metal affinity, in contrast to the mammalian glutaminyl cyclases that contain one zinc ion per molecule.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MATRSPYKRQTKRSMIQSLPASSSASSRRRFISRKRFAMMIPLALLSGAVFLFFMPFNSWGQSSGSSLDLSHRINEIEVVAEFPHDPDAFTQGLLYAGNDTLFESTGLYGKSSVRKVDLRTGKVEILEKMDNTYFGEGLTLLGERLFQVAWLTNTGFTYDLRNLSKVKPFKHHMKDGWGLATDGKALFGSDGTSTLYRMDPQTMKVTDKHIVRYNGREVRYLNELEYINNEVWANVWQSDCIARISPKDGSLLGWILLSKLSRGLLKSGHRGIDVLNGIAWDSDKQRLFVTGKLWPKLYQIKLKQASAKSGNYIEQQCLV
The following text describes a protein:
Function:
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MNHCFRNIIFLLLLCCSFSLENDLSYLKAFDDSIIYRLAWEKEHESLLKEVESLPTVTMVTARKEKYVCSIPKMLETKEEEIPIYEGPNPLQLLSPLFTQMSCSYRLESFWTYELCHGRYIRQYHEERDGKKVKLQEYYLGKFDKEKMDRQSAEIDAEIKIGERQEVPVRKIEGLSLPYLLVTMDSGTLCDLNGKPRMTRVYYVCYPAGKHEIFSLEEASSCEYEIVVLTPHLCQHPDYRAKESEENKINCWAVEGSPKKPSSLLDMEAESLMLQQQQNLLDSLGLSDSKFKVEFRQVDDVTGQGQKQTVAFITPSGGGTSGRKELNSDQQSSGIAKPETETSPRLQPPPTLPPQPVFDSKLVDDFLAGEYCLNGGTGWWKYEFCYGKRADQYHEEKDGSRTSIQLGVFNKEKHLAWLEENPSKRPKAIVGRKQVSHMYSDGGYCEMTNSRRRVEVKLKCKEITQTEHQQQSFTHSMNAVSLYLLEPQPCEYVLGVEAPFLCPLIDAADANGLIQLSDVKMANTVKTTLPEEQ
The following text describes a protein:
Function:
May play a role in the regulation of the epithelial-mesenchymal transition.
Subcellular Localization:
Nucleus. Cytoplasm, Stress granule.
Sequence:
MTSSPVSRVVYNGKRPASNTRSPSSNEIFTPAHEENVRFIYEAWQCVERDLRNQVSGMDRGVVEEYVEKNPSNSLKSFKPIDLNDLKRRTVQDPKKS
The following text describes a protein:
Function:
Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MHRTLLFLTWLISLTKAFNIKLPHTEKKDHLESNAVLACASYINTLKWSFDSSVVPGFYSTICSYSPAFDTWSLCIFNSLTDQIIPMDNTSFEESLGNVRKTCSFVDKKFSNISLEQYYSSLNNASSHALEDYGSIESLSTSIRVDRETRSRWIRAFHAHAYNLDISSVYGAYLTYYFVIVGIIAVFFHMSHYNGLNRALFASRFVNYIRGHFVLPTFLVDKHANHFKFLNVEVFTGLMPNSLEAWIIFGYTLANIIFLSISYIIDPYNLIFNSHLSQFTRLLADRSGILAFTQFPLIIIFTARNSFLEFLTGVKFNSFISFHKWIGRIMVLNATIHSLSYSLFAIINHAFKISNKQLYWKFGIASITVLCVLLVLSLGIVRKRHYEFFLYTHIILALLFFYCCWQHVKIFNGWKEWIVVSLLIWGLEKLFRIWNILQFRFPKATLINLNTSNNPHDEMFKVIIPKYNRRWHSKPGQYCFIYFLHPLVFWQCHPFTIIDEGEKCVLVIKPKSGLTRFIYNHILQSLNGKLQLRVAIEGPYGPSNLHLDKFDHLLLLSGGTGLPGPLDHAIKLSRNPDKPKSIDLIMAIKNPSFLNGYKSEILELKNSRSHVNVQVYLTQKTAVTKAANARDQLIHFDDIMTELTSFAHIGNARPNFSNVIENAIKSTPPGDSLAVVCCGPPVLVDDVRNTVSQKLLGYPERIIEYFEEYQCW
The following text describes a protein:
Function:
Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Most potently cleaves the synthetic substrate Met-Leu-methylcoumaryl-7-amide (Met-Leu-MCA), followed by Lys-Ala-, Leu-Arg- > Leu-Asp-, Leu-Glu-, >Leu-Lys, and >Val-Arg-MCA, while this enzyme does not hydrolyze Gly-Arg-, Gly-Gly-, Lys-Lys-, or Gly-Pro-MCA.
Sequence:
MRKLIFSLVTSFFLLLPSVIRADEGMWFLMFIKRLNERDMQKKGLQLTAEEIYSINNNSLKNAIVQFNGGCTASIISPDGLVITNHHCGYGAIAGLSTPEHNYLKDGYWAKDRSQELPPKSLYVRFFVRMDNVTDRMLSVVNSSMSEKERQDALNREMEKIQKENSEGGKYVVSVRPFFQGNEYYYFVYQDFKDVRFVGTPPENVGKFGGDTDNWEWPRHTGDFSVFRVYTDKDGNPAPYSPNNIPMKAKKYLNVTLKGVQENDFAMILGYPGRTNRWVSSHWVDQQVKYGYPAWVEASKTAMDAMKAHMDKDKAVRLKYASRYASLANYWKNRQGMIDALTAHKTADLKRAAEKKFAVWANKPENKAEYGNVLSDLATYFEKTNQEAANHNYLLLFFRASRIVPQANGYVKQLNTYLNSSSDQEKQQIRERIAKELDAYYSESYLPAEIDLFADNLKLYADKATDIPQEIAQIKSQYNGDFRKFAAEVFARSIFTTKENFENFMNNPSSDALQSDPIAQIARVMIDKYYNSQSEALKDGYEKAFRKYVKGMRDSKVSLILYPDANSTLRLTYGSVKSLPKDKRNHDVKRNYYTTFKTMLEKYKPGDAEFDMPKKFVEMYEKKDFGRYLDKDGTMHVCFLTNNDITGGNSGSPVMNGKGELIGLAFDGNIEAMAGDVIFDKKLQRTIVVDIRYVLWCIDTFGGAKHIVDEMTIIQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MYFSQEEWELLDPTQKALYNDVMQENYETVISLALFVLPKPKVISCLEQGEEPWVQVSPEFKDSAGKSPTGLKLKNNTENRQPVSLSDLEIQASAGVISKKAKVKVPQKTAGKENHFDMHRVGKWHQDFPVKKRKKLSTWKQELLKLMDRHKKDCAREKPFKCQECGKTFRVSSDLIKHQRIHTEEKPYKCQQCDKRFRWSSDLNKHLTTHQGIKPYKCSWCGKSFSQNTNLHTHQRTHTGEKPFTCHECGKKFSQNSHLIKHRRTHTGEQPYTCSICRRNFSRRSSLLRHQKLHL
The following text describes a protein:
Function:
Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. Utilizes UDP-galactose solely as sugar donor. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKKSKLDNSASHTRFGLVQFLLALLLFYFLCMSFEIPFIFRTGSGSDDGLPRHMVVVGREANRAIIVGEEADPHRPFEDPGRVNRAGHIHREFKTVSEIFTNESFFDAGGFSDELSTFHETVKHAISTGRKMWGNLGSGLITKPNPVKNRTEKCPDTVSVTGSEFSNRSRILVLLCGLTLGSHVTVVATPHWAHAEKGDDGKTTMVTQFMMELQGLKAVEGEDPPRILHFNPRVRGDWSGRPVIEQNTCYRMQWGSALRCDGHESSDDEETVDGEVKCEGWKRDDDDSDESKKTWWLNRFMGRRKKMITHDWPYPFGEGKLFVLTLRAGMEGYHISVDGRHITSFPYRTGFVLEDATGLAVKGNIDVHSIYASSLPSTNPSFAPQKHLEMQSMWKAPALPEKPVELFIGILSAGNHFAERMAVRKSWMQQKLVRLSKVVARFFVALHARKEVNVDLKKEAEYFGDIVIVPYMDHYDLVVLKTVAICEYGVSTVAAKYIMKCDDDTFVRVDAVIQEAEKVKGRGSLYIGNINFYHKPLRTGKWAVTYEEWPEEYYPPYANGPGYILSYDIAKFIVDDFEQQRLRLFKMEDVSMGMWVEKFNETRPVEVVHSLRFCQFGCIEDYFTAHYQSPRQMICMWDKLQRLGKPHCCNMR
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MAPRNGGSLDARKAILLGMGLLFVAYFIVVNVFFDLSGQSPHLAQQQDEPQLQAREFADEMAEAEAAEGDTAATPTSTRSWEPNPDRKYVWLDVAIDDVYVGRVTAELYADVVPKTVENFRALTTGEKGPDYAFKGSVCHRILKNFIVQCGDFTTGTGTGGRSIYGGRFDDEPNGLRLKHSKRYILQMANAGPNTNGSQFCFMLNAAPHLNGKHVVFGEVVEGFEVVDKMEQAGVERDGIPLQHKVSFTDGGEILY
The following text describes a protein:
Function:
Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKLNPRVAHNPVLSRIIESGRTNLPSGITSAGSLSAYAQAAAVTIRDNRDREKREIADLNNRLARYVEKVRFLEAQNRVLENDIGLFRQAAHIHTGKVRDYYDAEKTSLATLVREQEAKVSSAKQNIRKLEPEITTAIRTLASSLEHRQRVRSDKKEQLKHLSDLESETAYIKRLINDCDDEKSHLKTEISRIRGEIKRILALRDKERNGFSRSQTAAQDLLKKLNATISTHEIAIREEINKARRDSTDKNREFFHRELHMSMKEIRDQFESDSKKARKTWEEWYKKKITEIKKRSEKFSLTQNQAREEVLRIRSLLNELRTKISDADSMTQALSKRIEDMKFREDEELRMFEQSLTEKELAVTRMRDECAKLSVELETLVENQINLRSEIAHYRKLMEQAENLRTSYQSDFVIDTPSPLMRTSSHHYGSSYSLNVRDTHNKTVHHDNYDISSASTINTQQFRSYGKGDVKIIEHKDESIVIENSNSYKSKDLSNWKINHYVNGALTGTFILPVATHIHPHEKISIHSLKSPNLMDDIVATQIYSFDFSKNTKTVLLDDVDDEVGWYAHVSYSH
The following text describes a protein:
Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region.
Sequence:
MSAHEAGSSGRRQQATYHLHIYPQLSSAGSQTSCRVTATKDSTTSDVIQDVVASLHLDGSKHYVLVEVKESGGEEWVLDASDSPVHRVLLWPRRAQDEHPQEDGYYFLLQERNADGSIQYLPIQLLAQPTAACRLVERGLLPRPQADFDDLCNLPELTEANLLQNLKLRFMQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYAMLRKHVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYLENGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERLEFQLKQPQDYFYLNQHNLNIEDGEDLKHDFERLQQAMEMVGFLPATKKQIFSVLSAILYLGNVTYKKRATGRDEGLEVGPPEVLDTLSQLLKVKRETLVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDMEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFTQHIFKLEQEEYQGEGISWHNIDYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSHTLLAKFKQQHEDNKYFLGTPVLEPAFIIQHFAGRVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAAGISSPATRSHMEELPRGASTPSEKLYRDLHNQIIKSLKGLPWQGEDPRRLLQSLSLLQKPRTSFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPKDVQPCREAIAALLEKLQVDRQNYQIGKTKVFLKETERQTLQEKLHGEVLRRILQLQSWFRMVLERKHFVQMKHAALTIQACWRSYRVRRALERTQAAVYLQAAWRGYLQRQAYHHQRHSIIRLQSLCRGHLQRRSFSQMVSEKQKAEQAREAAGGKLSEGEPGPVAAGEQLSEHPVEDPESLGVEAETWMNKSPDGMSPKKETPSPEMETAAQKTVPAESHEKVSSSREKRESRRQRGLEHVERQNKHIQSCREESSTHREPSRRASLEIGESFPEGTKGPREDGLEAWTETTAPSSSKQAQVVGDPPGSPSPVQRPTTLALDSRVSPMLPSSSLESPKDKDKDESSTKAQDKPESPSGSTQIQRYQHPDTERLATAVEIWRGKKLASAVLSQSLDLSEKHRATGAALTPTEERRISFSTSDISKLSPVKTSAEIDGDFSSKKPSIHKKKSGDPSAGPDAGLSPGSQGDSKSAFKRLFLHKAKDKKPSLEGVEETESNGGQAAQETPARKTLDVPSSQQHRHTTGEKPLKGKKNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIESLFIEATERFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLAAERGEKDTNLVLNVFQSLLDEFTRSYNKTDFERAKSKAQKKKRKQERAVQEHNGHVFASYQVNIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLSAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKMKMEEINHLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVRIKSPRTPVVQDLELGALSEEAAGGDEDREKEILMERIQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESLLEERGVRGAVEGPPAPALPCPISPTLSPLPEAAAPPRGRPTSFVTVRVKTPRRTPIMPMANIKLPPGLPLHLTSWAPALQEAVVPVKRREPPARRQDQVHSVYIAPGADLPSQSTLIALDHDTILPGTKRRYSDPPTYCLPPSSGQANG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Subcellular Localization:
Nucleus.
Sequence:
MAVDNEKKRSTPDSLNSPHAKKSKPMQELSESGPLTQADVVYFQKEAIWRQMIQYKQQMMSMRSELIRLQRESDASKHIVTVLTAWYEQILALFDELNSEETSDLLLAITKNDDEQLDLIRKKLSNLISSKVTFDSAKYEKVSGELALLSRQNEQMTEEKRSLGERIDELESKITELAKEHERAQSKTLKRLDSQRHIKTEEDEQSTTKEENPQPNGHHKENDKTAVVDSEELDNLKCELDKLKTANQLLVQQVEQLTKENQSLIQKSLNLENKLHNLEESDLEDNTYYKKIVKNNQSLQEQIGKLTKLNSSNVSRLNELERQQNDLKSVIEGEIIEENEKLKQQLQESENNLVRIRTTRDELLSKNNILTSQLQDQKTNESLVELNNVLSKRVESLTEERLEAIVGTPGTGKLEDLSQQELIHKISQLNNEIKEVELAFKQTREITLKKLTSSIDQENLTKKLTIEKNKADQKYFSAMRVKDSLTNENKLLKAQIAKSQDLIKNLNDLEKKYLNKIDLLSNQLVDFRIIKENSLAENSKLHDELKTLNIAQDALHQEVERVNAKLESTLKEHTDLQESNKKRELELAKLQKQLQSTENILQKYKTNNTNSLLQEDEQQLEALRSIAKCSVCSKNWKDTAITVCGHVFCSKCTQERLAARLRRCPSCNRGFSANDLLSIHL
The following text describes a protein:
Function:
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MIGDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVKGKVAEMMQNERLGGLSVLDAEFSKTWEFKNNNVAVYSIQGRRDHMEDRFEVLTDISNKSHPSIFAIFDGHGGEAAADYVKAHLPETLKQQLQAFEREKRESSVSHANILEQRILAVDREMLDKLSANHDEAGTTCLVALLSDRELTVANVGDSRGVLCDKDGNAIALSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDIMTFDLDKLQPEFMILASDGLWDAFSNEEAVRFVRERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFKSGTGGSSKASD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNSRAAAVEPVQVSLFFGLHANTANADSQRDRAPPFTNMDPFSSLNDTRRSDKKPKDEKPDYNNLLPVIKQEPDSYCGADIAEDEAEILQIKIEKEESDSEYDGETLEIVSRKVKLENDWSVCNEYQIMAQTDQETLQGIIKEEDYEGTMAAVADGKDEEHWQLHTLRSQSSASDSSETLVRDRELLSPSRSDSEAESGPVCTSLANVTKSHKRNPTDKEPLICPSCGKNFRNQQKLKIHLAIHNGERPFTCTDCGKGFAAKRLLRIHLQVHTGERPFSCKECGKTFARRSHLYTHRKVHTGEKPYICTECGKSFARKIHLNNHHKVHTGEKPFTCIECGKSFSQKTNLSKHHKVHTGEKPFTCPDCGKSFSSKSNLHVHQTIHIRRYLPFVPDMGHGSV
The following text describes a protein:
Function:
Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway.
Subcellular Localization:
[Isoform 1]: Cytoplasm, cytosol. Note=Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail; [Isoform 2]: Cytoplasm, cytosol. Note=Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail; [Isoform 6]: Nucleus; [Isoform 7]: Nucleus.
Sequence:
MTTEVNQLSEHPLVSPKAEPQPETKPENLPRSHGDVGLQKETVVPGIVDFELIHEELKTTKPQTSQPTPSAYRFGRLSHHSFFSRHHPQPQRVTHIQVTGREDLEHSLPLTTSFQLLQAPGVQPMDLTPSADIAGKPVCVVRDEFSLSALTQPTFLSRCLMGMPTISVPIGDPQSNRNPQLSTSDTWRKKLKDLASRVTVFTKEIQPKPDEQKEEPPLREPPPREQGAKYSAETGRLIPASSQALTRRNRQGQRVHPSSKDGGVQASILQDQELLILELLCQILQTDSLRAIQFWLLYAPSKEKDLALGLLQTAVAQLIPQPLSSIPAEKLWNHLQELQEPQETQEAAYSPSLKKTRSPPLPKTDKPEYIGKAQVLLVHPSEDPEEKTTKAES