lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Seems to associate with GPA2 and act as G protein-coupled receptor that senses glucose and controls filamentous growth. It acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MITEGFPPNLNALKGSSLLEKRVDSLRQLNTTTVNQLLGLPGMTSTFTAPQLLQLRIIAITASAVSLIAGCLGMFFLSKMDKRRKVFRHDLIAFLIICDFLKAFILMIYPMIILINNSVYATPAFFNTLGWFTAFAIEGADMAIMIFAIHFAILIFKPNWKWRNKRSGNMEGGLYKKRSYIWPITALVPAILASLAFINYNKLNDDSDTTIILDNNNYNFPDSPRQGGYKPWSAWCYLPPKPYWYKIVLSWGPRYFIIIFIFAVYLSIYIFITSESKRIKAQIGDFNHNVLEEEKEKKKLFGLGHWGKAKWYFRSYFKLPLLHLLRNLKNFFTISFIDPNEETDDSGSSNGTFNFGESSNEIPTLFRKTNTGSDENVSASGGVRLLDYNSAKPLDMSKYAMSEQPDLERNNPFDCENDITLNPSELVSKQKEHKVTFSVENEGLDTRKSSMLGHQTFSCQNSLESPLAMYDNKNDNSDITSNIKEKGGIINNNSNNDDDDNNNNNDNDNDNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNIKNNVDNNNTNPADNIPTLSNEAFTPSQQFSQERVNNNADRCENSSFTNVQQHFQAQTYKQMKKRRAQIQKNLRAIFIYPLSYIGIWLFPIIADALQYNHEIKHGPTMWVTYIDTCVRPLSCLVDVIVYLFKEKPWNYSWAKTESKYLIEKYILKGELGEKEILKFCHSNWGKRGWYYRGKWKKRKCWKYSTNPLKRILWFVERFFKQLFELKLHFSFYDNCDDFEYWENYYSAKDSNDNKRTESDETKTNSSDRSLPSNSLELQAMLNNITAEEVEVPLFWRIIHHIPMLGGIDLDELNRLLKIRYNNDHFSLPGLKFALNQNKSHDKHQDVSTNSMVKSSFFSSNIVTNDDENSIEEDKNLRYSDASASENYLVKPTIPGTTPDPIIEAQNDNDSSDSSGIDLIAFLRNGPL
The following text describes a protein:
Function:
Controls the expression of genes used for utilizing diverse lipids as energy sources.
Sequence:
MTTSSRSRSSTVAAATLGEDDLSSNAQKERRKRILDATLALASKGGYEAVQMRAVAERADVAVGTLYRYFPSKVHLLVSALAREFERIDSRGKNPPGRNPLERMQLILSQITRAMQRDPLLTEAMTRAFMFADASAAAEVDQVGKLMDRLFARAMTDTEPTEDQLAVARVISDVWLSNLVAWLTRRSSATDVANRLELTVELLLGDGSRRPE
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. A probable antitoxin for the putative mRNA interferase YeoB (By similarity).
Sequence:
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNARRLLDSIAEAEAGDATEHDLIDPDAERA
The following text describes a protein:
Function:
Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to active transcribed genes.
Sequence:
MSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLTVRRTKPKKRKKSPEKGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARRKELEMEQQNEASEENNDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKEEVIDDQENLAHSRRTREDRKVEAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSAQRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVVSITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNSGSKSPQLATPGSSHPGEEECRNGYSLMFSPVTSLTTASRCNTPLQFELCHRKDLDLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPSLGPTSETGFPSRSGDGHQTLVRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERACEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENSAGGGGDSAQSKSKSAGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKFSPSHSSMSHLEAVSPSDSRGTSSSHCRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNITEKDSDPADGEGPETLSSALSKGATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSPFRGHPTQSPGYSYRTTALRPGNPPSHGSSESSLSSTSYSSPAHPVSTDSLAPFTGTPGYFSSQPHSGNSTGSNLPRRSCPSSAASPTLQGPSDSPTSDSVSQSSTGTLSSTSFPQNSRSSLPSDLRTISLPSAGQSAVYQASRVSAVSNSQHYPHRGSGGVHQYRLQPLQGSGVKTQTGLS
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle.
Sequence:
MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRHLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGAKEETPGQRPVVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQIAPEPPKPYSLVRETSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKIHTTALTGQSPPLASGHQGEGDAPSVEPGATNIQQPSSPAPSTKQSSSPYEDKDKKEKSAVRPSPSPERSSTGPELPAPTPLLVEQHVDSPRPLAAIPSSQEPVNPSSEASPTRGCSPPKSPEKPPQSTSSESCPPSPQPTKGSRHASSSPESLKPTPAPGSRREISSSPTSKNRSHGRAKRDKSHSHTPSHRAGRSRSPATKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGKSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSQARRSGRSRSRTPARRSGRSRSRTPARRGRSRSRTPARRSARSRSRTPARRGRSRSRTPARRRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSHVSSRRSRSLSSPRSKAKSLRRSLSGSSPCPKQKSQTPTRRSRSGSSPPKQKSKTPPRQSRSNSPQPKVKSGTPPRPGSVTNMQADECTATPQRQSHSESSPDGEVKSRTPSRQSCSGSSPRVKSSTPPRQSPSRSSSPQPKVKTVISPRGRSHSSSSSPSPSRVTSRTPQRKSRSISPCPKVDSRLRHSRSRSSSPDSKMELGTPLRHSGSTSPYLKSMLQTPPDQNLSGSKSPCPQKSRDSPTGSSGSFHLCPGVTPSSIVPGESCFSASFVQQKGHTQTWPDTSSPEVMQTQVESPLLQSKSQTSPKGSLSRSSSPVTELTARSPVKQDKSEISTDPKLKSGMSPEQSKTKPDSSIYPLVDSKSFLVQSRLEPSELKERLGLIQEDVASSCIPRDKFSPTQDRPESSTVLKVTPRVLLKERSGAGSPPGKRDQKSLLPNSSQDELMEVEKSEQPLSQVLPSLSPEHKEMPGSNIESSPEVEERPAVLSALDQSQSQPSKAAETPAVASCWSGPQVSPEHKELSHSPPRENSFESSLEFKNSGPVSEVNTGFSPEVKEELNGSFLNQTEADPSVDMKEQSRSSRRSSSELSPEVVEKVGLFSSQKVSSPVLETVQQRTPSRERSSSASPELKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDTPQTPSRGRSECDSSPEPKALPQTPRARSHSPSSPERNNKSVTPQRERSGSESSVEQKNLARTSPGQRSRSGSSQELDGKPSASPQERSESDSSPDSKPKTRTPLRQRSHSGSSPEVDSKSRHSPRLSRSGSSPEMKDKPRVLQRAQSGTDSSPEHKIPAPRALPRHSRSGSSSKERGPSPEGSSSSESSPEHAPKSRTARRGSRSSIEPKTKSHTPPRRRSSRSSPELTRKARVSRRSRSASSSPEIRSRTPPRRRRSPSVSSPEPTEKSRSSRRRRSVSSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPTRQESSRTSSRRRRGRSRTPLTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSVNRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRAARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALSSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSARTPMSVLQQTGGSMMDGPGPRIPDHPRSSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTSAIPASVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPAASAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPTPANLVVGPRSAHGTAPVNIAGSRTPAGLAPTNLSSSRMAPALSGANLTSPRVPLSAYDRVSGRTSPLMLDRARSRTPPSAPSQSRMTSERERAPSPASRMVQASSQSLLPPAQDRPRSPVPSAFSDQSRSVVQTTPVAGSQSLSSGTVAKSTSSASDHNGMLSGPAPGISHAEGGEPPASTGAQQPSTLAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRVPSPTPVPKEAIREGRPQEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRQPSPQPSPRDLQSSERVSWRGQRGDSHSPGHKRKETPSPRSNRHRSSRSP
The following text describes a protein:
Function:
Binds to apicoplast RNA transcripts, preferentially to the motif UUAU, and protects RNA transcripts from degradation by ribonuclease.
Subcellular Localization:
Plastid, apicoplast.
Sequence:
MKLTYYYYAFCIIKVIASLRLDSYKKQNVFFLKAFFKNVINIKKERKKNLVNSFFYVGRRNKIPIKYSNNEFYNIHNENYDNTKYYNNNNNTNDYDKKDNNVGKRKYSRKNMLYMNSSEKDNFLNENILKKKSSEKEIEQSLTPLNMDWVKVMNLIYSSNDIDATTLAFNAAMSAVEKKGCLSTMLDLIGTMKSKNIKPDLVSYKLVLSLCDKYHLVDTAEILFEEMIESDKINPNYEIYAIMISCYAKTGNGYKAIELFEKLRNDPFVEEMRSLNITNTNDNKENSNDLQTSIIHNNMEDNNNNNNNNDNNIYDDKFKHISNKIKNVENCSGKIQYSEYANVIYACNISNLYEQGIKYFEELLKSGKYMPSIFVFENIFDLLSKNGDYEKSLEYYNNLKNDPNFKKNINVNILNNLLKALSIHNKINVAEDIWNNEFDELLLTPNNLSYQILLKIYSHIDNYEKAFKLFKEMQVNKLLNNKNILPFIYTIESTKNCGIYNYAIYVLRVAKLLNFKANDLLMLYNNTMISCINSKKYDVIISLYAELINMQQKDTSFQININTLTFVLLAFKELNMKQDFINLKNIIIQRNYKLPPLCSKIFSETENY
The following text describes a protein:
Function:
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.
Domain:
The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein-protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm.
Sequence:
MNTEATHDQNEAQTTGVRLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPSDLASTFLRGYIRSYARLVHVPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMSFTWLVLFVVVGLTGAWWWQNHKAQQEEITTMADQSTAELNADKDSGQSVPLDTGAATSQDTTPAQTAPAPATPVDSTAATQTPAPTAAATQNTVVAPSQANVDTAATSAAPAATETPSALPTSQAGVAAPAADPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEPTPAQ
The following text describes a protein:
Function:
Involved in bud site selection. Required for resistance to the DNA-damaging agent methyl methanesulfonate (MMS).
Sequence:
MFCTWDSWDTGTSRKSHSPHRNCLAVRFLQLPFSSFLPCVITYMKSWQTSIGDSEFPLTSFQILVTDAEVVVQRIFDCINGYLPGWHYRNTVFIEHTTSYHRSHFCIFVEGVWVCGEFVKKWFEIPFDNRIENYTKQFPWILIGFGNQVSKAL
The following text describes a protein:
Function:
Transcription factor which regulates the expression of genes involved in lipid metabolism and autophagy in response to nutrient availability, bacterial pore-forming toxins or heat shock. Binds to the E-box motif 5'-CACGTG-3'. Under fasting conditions, binds to the promoter and activates the expression of lipase genes lipl-2, lipl-3 and lipl-5, and to a lesser extent, lipl-1, thereby regulating lipolysis. Involved in modulating longevity in response to TOR signaling, dietary restriction, germline signaling, heat shock and the insulin-like signaling pathway. Involved in the immune response to infection by the S.aureus bacterium, probably acting downstream of the protein kinase dkf-1, leading to the transcriptional activation of host defense genes. May also play a role in lysosomal biogenesis in response to nutrient availability.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localization to nucleus enhanced during fasting and on mutant backgrounds involved in modulating longevity: glp-1, let-363 (tor), eat-2, daf-2, clk-1 or rsks-1. Nuclear localization abolished on mml-1;glp-1 or mxl-2;glp-1 mutant backgrounds. Localization to nucleus enhanced as a result of bacterial pore-forming toxin treatment, or heat shock; Nucleus. Note=(Microbial infection) Localization to nucleus enriched rapidly after Staphylococcus aureus infection.
Sequence:
MIRQLNSPGGGGGLGLNNPRAQQPPGAQQQQQPQQAQQQFYDDEPYQANASQFRFGAGKSMEQRRETGNLIPIAQRSMGSTSTPFGSAPTQSYFGGGSSGAALSSPRKMQQTHQMLFGNIQPPRGSPPSDGSDKIHRFGESPTPGGVGGVFGTELDDLIIDELMGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQMSPDIHWDASGFSPDPINTQQSNSGHYHMDFS
The following text describes a protein:
Function:
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Sequence:
MATRLQYDNNNCEIGVFSKLTNAYCLVSATSASANFFTGYESKLKGVIPIVTTSIGGSGTIGSLCVGNKNGLLLSHTITDQELQHLRDSLPDEVVVQRIEEPICALGNAIACNDYVALVHPKLEKDTEEIISDVLGVEVYRQTIANNELVGSYCSLSNNGGMVHSNTNVEEMVELANLVQVPLVAGTVNRGSQVISAGLTVNDWTAFCGSDTTAVELSVVNNIFKLVQSQPDFVGSEMRKSLIDTYV
The following text describes a protein:
Function:
Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDEEEAELCPILPAKKQGGRP
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRFEVRNEYGLGQGELYREANSEGDSKAVLDGVAVAGLVGILRQLGDLAEFAAEVFHGLQERVMSTASRSHKLMVRVQNIEAALPPLEKVVLAQTSHIHFAYTPGSEWHPCIQNEQNHFIYNDLPRFIMDSYEECRDPPRLHLLDKFDTGGPGSCLKRYSDPAYFRRVSGNVTGPDAEKLPKDKRARKSKKKHSSPRNGDVAHYASMSNHSGRMQFTTPNGNGQTSPSHTASTIDTTLKSDAGDHSNSFDSRTGSGYIECVFHLNSSVQAEEEEPKELSSRFMQQNDVPDSVFPDRQPGMADNNFHHTSSPEQIAAPISSCVTWDEKEEIVEPSGQHYDEDEISEVLAAEPDLDTHDRSTVNLKNPNPLDIVLDGANTPKSSSSRSQLDEVESEPDDFMDALNTIESESENDIDCQTKCEVEQFSSSVNNEVEETILEVTSHISDHHPSEYESRTLSVISSNEKSPCELPSSVSLKSFAYEQESHVSGNSSKLDSSPGIECSRSANVLDNSKVESVSDPPSSSVSATSISNAEGPLSDKIISSSNKSQESQNDFSSVQSTTFWTNGGLLGLEPSKPPDFAVSNAKSPDSVTRSKDETGLPTNHTSMPINDGGKPGRLIKDAGSIESAPTSKGSTSWHDDQDSKVEKPGDFHQGNRISHGYEDGPNITSAVTPGNELQHDSYSKVPPIESSQENDENSYRRLGFGHRLLVNGFSRKVSLVHDGEREPARLLRSGALEQQSWHNEVTYQATPEKAYNKQLGHKYSIDSITSSPPLEHMKISFHPIDGFEDSKLKLKFPDGNHGNESIRDMFPSFQLIPETAIPLCNVGSDSDDDTFCRSSPYMSDDHLSHHSESDSERWDSDDSPESKDHELYDALRRISPVESFSSSLQPGEAGNNQSTYTENGTDPSLSASSLDLPCFDAMNSVVYGEKKDNLHERNQQELEYLKDSTPLPPPLPPVQWRVSKPNSDISEGKLHALSEGHEHGFDIKPLESTVPQQPKPSPADDHKMNEDTIAFKPKSKEQDQQKLNCHKEANQYANGKDIDEKDDFLHQIRTKSFTLRRTGKAKPSLSSGPTANNKVSAILEKANAIRQAVASDDGEDDTWSDT
The following text describes a protein:
Function:
Mediates uptake of L-cystine, the oxidized form of L-cysteine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKQTKAILIALFLGLVVGLTLNLAAPSIFEPLNQYVFNPIGQLFIRLIKMLVVPVVFISIVLGAAGLGDPKQLGRIGLKSISFFLVTTAVAISIAVTFALIIKPGAGGNFKTEGLKYEGAKTETSFVDTLLNIVPDNPAKAMADGNMLQIIAFAVLIGLGIAILGKRVQGIHSLLEQGNELMMYLVNLVMKLAPIGTFGLLASSVGKMGLAGVAAMFKYMIVVMLVLIIHGVFVYGGLLKVLAKESIVRFFKHFGPVMAIGFSTSSSNASLPFAMKTAQDKLGVPKAISSFVQPLGATINMDGTAIMQGVATVFIAQVYGVELTLPQLAMVVLTAVLASIGTAGVPGVGLVMLTMVLNQVNLPVEGIALIIGIDRILDMSRTAVNISGDAICAMIVAKSEEKYNTDQSAAS
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor.
Sequence:
MCLAIPAEVTKLLPDEMAIVSIDGVSKEISVALIEDLAVGDYVIIHVGYALTKIDPEEARRTLELLRELSTEGQGAAS
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MACSARGRSAGSTPGLGPPSDSEQLSRSYPWAGGGGRSRLAGLCRRGASLSGEKWSSYCLSSLAAHNISVGSSSCSFVHTPALEESSQHFLTAARNPNQAIFTVDVTTTEILVANDKACRLLGCSSQELIGQNLSRFISKCNQETWEAVDDEYLETDECTSMVSGTVVDVINCLKEKIPVSVWLRRIRIKDNQRCVVLLEPVERLSAFVSFRADGGITSCDLLFAHLHGYPTLEEVVGLHIKDLIPAVQIPLLGKKIPKNLKVQRAVGRSREGNVFPITLKLQVSLLEEDQVAAQNNGVLQTEREISFPDYHYAATVEVFSTISGLITVQSDGTIQCIKDSFALTLFGYEKKELLGKNITFLIPGFYNNMERSDDCSLPLPPLDDSLGMESECFFEDVSACHTAGSGCRSKANLLSRDEEQKLERRHREDRLLPGETKQKIGSSLLSIPSSPEVAAILSNREGSIVADGLSAHCGEPSPETQPDRIRALEHCGVEENARSCNPPEMHPAWVSPPSSASEQLDLDQNLKTPLRSGHSAASGTSETGNASESSFLLNQLHVHHQDPKELNCQQVSRMPHEMLKDQHSTVAQGQSSSANVAWLTIFSSPVDKLDTVSSGVSKPPSCFPCNSSGTLKINEPQPGTTLGCTQDFQSHVARGQLTKTSFVCDGKHSSLEHTVAESSLLKDANVIANGRNSTHDVCSGNTVGCTGSALGAASTFQTMRQTDTELNCICSDLKELDLNIGVTGNSGNCLGSTSDFVEVFFSNTVNSAAGTMLTPKSGLFSAEQLLNGVAIKDGSGCLPSQQHLENPEQSSKVFIEKPKTLTETVGDNVNRNILKSKGNPEEDCQFHGQESMEIKVTSTPVKQEQRPNHAAPFSAEILEGSYSGNCSHRDGSQLSILFEVRRVELQDPAVLFCVWVVKDLLQSQKEAVAKTQLLLSSLAGSTQSVLDLSTHSLGEAIKSSSLSENSRRAEELERLRACEGEYATHYDTLSLIGKGSFGFVWTARSKKNHQEAVVKFIWKERVLEDCWVDDPDVGRVTQEIAILLKLQHPNIIKVLDVFENERFFQLVMEKHGSGLDLFTFIDNQPDLDEPLASYLFRQLVSAVGYLHCRNILHRDIKDENIVIAEDFTIKLVDFGSAAYLQPGKLFYTFCGTIEYCSPEVLSGKPYHGPELEMWSLGVTLYTLIFGENPFCELEEAMAAVLNFPRLVSKDLMNLIVGLLHPAPEQRTTLAMLVEDPWLKQPVNLGDYTWEEVYISAGAESNGLRNGSVECSRRDRPSAPRMESEPCLSASSCVCAHPPWEGAAAVRCQGWSLGSRCSRSLQQPLPVQH
The following text describes a protein:
Function:
Has DNA endonuclease activity. Binds DNA.
Sequence:
MNLDDKSLFLDAMEDVQPLKRATDVHWHPTRNQRAPQRIDTLQLDNFLTTGFLDIIPLSQPLEFRREGLQHGVLDKLRSGKYPQQASLNLLRQPVEECRKMVFSFIQQALADGLRNVLIIHGKGRDDKSHANIVRSYVARWLTEFDDVQAYCTALPHHGGSGACYVALRKTAQAKQENWERHAKRSR
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Subcellular Localization:
Cytoplasm.
Domain:
The U-box domain is required for the ubiquitin protein ligase activity.
Sequence:
MTDQENNNNISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDEFDYSVAEISRSFRSQQEICEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQALFARLLLQDPGNHLINMTSSTTLNLSADRDAGERHIFCYLYSCFQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDVTEFLEEVIEALILDEEVRTFPEVMIPVFDILLGRIKDLELCQILLYAYLDILLYFTRQKDMAKVFVEYIQPKDPTNGQMYQKTLLGVILNISCLLKTPGVVENHGYFLNPSRSSPQEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHCILSWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCALKELNDEERKIKNVHMRGLDKETCLIPAVQEPKFPQNYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAIGNEGSQPIELTFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFADDILETSADSLEHVLHFITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPNPLVSSVFHRKRVFCNFQYAPQLAEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDTYRESIKDLADYASKNLEAMNPPLFLRFLNLLMNDAIFLLDEAIQYLSKIKIQQIEKDRGEWDSLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLAFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIVAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQLE
The following text describes a protein:
Function:
Necessary for efficient spore formation.
Sequence:
MSEFFWDVQKIQEISNVEEHSVVKCVTVNTSRLISQLNEELQDEESGVNFIVTQLQLLINNVYEKIQKSPGVPAHRSLMINLNFTRLKFSIAYWDILLERSLDLINGPSKTGARYFITEVTPVDRSRYVENNQYFLAFKANQRLTRNSVDMDEFIDFEILIKQIIFDLFKKNGIPDQDFEAILSRFHNLESLVVAFNE
The following text describes a protein:
Function:
May be a transcription factor part of a circadian clock input pathway. Acts within a 'zeitnehmer' feedback loop and is involved in its own circadian regulation. Has no role in regulating circadian clock function in the dark. Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9. The activity of the protein may be decreased in long day conditions due to its interaction with phytochrome B (phyB). Can regulate the initiation of flowering independently of phyB. Also involved in responses to nematode parasitism, like the formation of the nematode feeding structure.
Subcellular Localization:
Nucleus. Note=Forms nuclear bodies.
Sequence:
MKRGKDEEKILEPMFPRLHVNDADKGGPRAPPRNKMALYEQLSIPSQRFGDHGTMNSRSNNTSTLVHPGPSSQPCGVERNLSVQHLDSSAANQATEKFVSQMSFMENVRSSAQHDQRKMVREEEDFAVPVYINSRRSQSHGRTKSGIEKEKHTPMVAPSSHHSIRFQEVNQTGSKQNVCLATCSKPEVRDQVKANARSGGFVISLDVSVTEEIDLEKSASSHDRVNDYNASLRQESRNRLYRDGGKTRLKDTDNGAESHLATENHSQEGHGSPEDIDNDREYSKSRACASLQQINEEASDDVSDDSMVDSISSIDVSPDDVVGILGQKRFWRARKAIANQQRVFAVQLFELHRLIKVQKLIAASPDLLLDEISFLGKVSAKSYPVKKLLPSEFLVKPPLPHVVVKQRGDSEKTDQHKMESSAENVVGRLSNQGHHQQSNYMPFANNPPASPAPNGYCFPPQPPPSGNHQQWLIPVMSPSEGLIYKPHPGMAHTGHYGGYYGHYMPTPMVMPQYHPGMGFPPPGNGYFPPYGMMPTIMNPYCSSQQQQQQQPNEQMNQFGHPGNLQNTQQQQQRSDNEPAPQQQQQPTKSYPRARKSRQGSTGSSPSGPQGISGSKSFRPFAAVDEDSNINNAPEQTMTTTTTTTRTTVTQTTRDGGGVTRVIKVVPHNAKLASENAARIFQSIQEERKRYDSSKP
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
Subcellular Localization:
Cytoplasm, P-body.
Domain:
The N-terminal zinc finger binds to poly(A) RNA; Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs (By similarity); The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.
Sequence:
MCSTYGLLSFEFSDTAAMDPIFFSPTNGIPSESKLATYMNRQNVATPSGYGLNNGFSLLNLDSPLNKKSQVTPQSPEFIPTRLGSTPNFYAPYHNAPMQLSNGLNGVNGLTAAAAAAAAAAAAAAAAVPSSTSSASSASVTISKTANGGASMLALQKTASIASVTIAQQQPQHPQKQQQHPPSVGGGAVSAASAPIAISGAPPNPAAAPFVSSMSAQTPLKGRGAMMRQESPTAAMISGAGPGEKSPPHGMTPHGASPIPSALPTSVHQENVGGTIYFYPTANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGVPAAMMYTGHVYPGPSSNVVTMQPKTLLESAFFMPDEMRAEVLARNEISNLIMDAAEAAQHALPLEVENYHALYPLEPPAQPLHAKLTFPATTYRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISDITQFDPNASNPLALVNMHQQDDLTALGRLVLALACRCLQSVQRDNVQSSIDMVTRNYSTDLRNFIVYLFTTNNRRSVTDLMPMIGARFYTQLDALQSKIDMQEDELAKEMENGRLYRILVKLNSINERPDFNLDCTWSETGDRYMLKLFRDYLFHSVTEDGRPWLDHAHIVQCLNKLDAGSIERVQLMSRDEQSVLIVSYAELKNCLENAFSELMSSAAN