lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Subcellular Localization:
Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Domain:
WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Sequence:
MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MELFEQFEEQDGVRFNWNVFPSTSRDAKDVVLPISCVYNPRHKAQTVPVVQDTIAICGNKDCGSILNPYCHVDLASQTWTCRLCMSRNRLMSSVAGQLPPACDPANSTVEYNTARTAATPPAFLFVLDTNAEPEELESLKDSLTQVIDQLPEHCIVGLLSFGSSVQFYQLGYPHCLRSLVFNGAKSYAAKEIEEAFGYNGGVPGNRRMEITNQFLIPQTESFAIVDALQQIKANKIGPKEGDRFARGTGTAINVALSFAETALNQGFVRIGVFTAGPATIGPGKIVDMPLKEPIRGHHDIQNGSALHHKAAAKYYGELGTRAAAGGFAVDLIVGSYDQVGVAEIGTLSHQTGGVIILSDSFTTSICKESIRRHYSFGDENVGMAHAGARAVVEVKTSSELKCQGMIGHGVSLAKRSKAFASEDKYIGIGQTCAWSLASISPKSNYCFYFLNTAETPTLPPSNQSVATGVIQIITHYLHPSGVFRVRVSTLARNFGPAHGLLPYFDQEAAATAVSRETAFRMQHGESADDTIRWLDTVLVKFCNKFGEFRKGDTRSFILPPNCTMLPQFLFHLRRSQFVQTFNNSPDETAYYWHYLLAENVYSTIVMINPALLAFELDAPEGIPVLLDSISVTSERILLLDTFFHVIIFHGETVAAWRNAGYHEQEEYGNIAELLDAPKEEVRELLSDRFPLPRYINCDQGGSQARFLLAKLNPTTQSMDMAGAAPGTVVLTDDASLQTFMESLCKLAMNL
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAATRGICLALSLFVICCSALQVDVVPENDLLQLIQKLKAAQPYKDLVTAYYSVVGLEALNEKVPENQDVCAFIKKSMTSNLVNLYFGAFIGDSLKCNLTPPKDAQKVLNDVILDGRTTFLIYQAVGALTKFNLKVDASMVVKSLKSALEKDDSTASHSFAFHAAAFLPKDADIGTIPNAIGEVLNQADEIGDKYLQFDGGIRDTILFVTGVYRLCYARGLTPAIDNDQAIKLANYIVSKRHVGSVRNAYYVALGLQAFTENKFQIPGSVVLTSQALIRKNDGNIVVKACNILGKPLPKMDVKATSIVSTEGNTIASDVDLVEKSAGEYQFDFNKMKPERGFYTVHFNVAPVVEDKRLIGLQDSSFKVKKVVNVAVESFKVKTSDIDQASVQKEARATFPKGLASNIQADEHSNVAIEFIVKDVEKNVEIVPQQAFLRLACDKCNVDRSFLFTNRNEQLLSLELDITELRKTFYSQSGNYSMDVIIGDPTFSNQIYWKVGSLSLKFTTTGAAAPSTKIPPSSKPEIQHVFRVPEKRPPELVSKAFTLLVLSPLVIMFVMWNLFGANVSNFSFTLPNIVFHLGVGAIFLLYYCYWTNLNMFTTLKYLAVIGGITFVSGTSVLRSIANDRMKKELR
The following text describes a protein:
Function:
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIGVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPSEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGTEFEGAIIALFHLLATRTDKVRALREGFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSTRFSGNFLVNLLGTWSDATSGGPARAYPVAGLCYYLSPPESFGSVLDDPVHAGIYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGGLSVMADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
The following text describes a protein:
Function:
Master transcription factor that controls the differentiation of acute-stage tachyzoite parasites into chronic-stage bradyzoites, which form intracellular cysts resistant to immune clearance and existing therapies. Sufficient to drive differentiation into bradyzoite stage. Following translation in response to stress conditions, binds to the promoter of many chronic stage-specific genes and promotes their expression, thereby driving differentiation into bradyzoites.
Subcellular Localization:
Nucleus.
Sequence:
MEGASTQPMPHSQRERQAPVHAISGTWENCDQAGEYKGTACCVVERQVYSTETHAVEGCCSTRWNGVKEEKGGGEVSSRTALAGVVHLYTNSDGNAYTHISDQGMRQDEAVAGQEQRHLNCEGEHEKKGNVAAGGGTLMVTKSEIEPCDDYYSVQRGQSCAGERAPRDGCCRLLDGSRVDPAEGGSEEDENCYTHVLQKHLGQMPTAPYQGDDRLQTDLRLGDFQSGPSDALSGHHVTRTPILSPHGRYSEYISERLAWQYAERPGHGIAAENTVVMHSHTGEATGSLRADAPSQWSTESRLQFHVGSQFTTENPELFAGIVGLDTEQFDARNAEALHWRQQGEARSTETECIADITPERGNRSTIRQWNKPEAARQEYHRASASARGPEETNIITRGAHSDDQSIDAAAPGCWAARHLTSRQHPNPRPRMKEEHCGREREVLSSEQPSDCGETQKTPASHSLVLDSKSRADASQTSPYTRNDEIQTIRAFEEQCLEVQLPQSRLRRGIDYEAGMSQLAPTTQELKAKVLTTGLSPSCPNAAVLRASVPLSMDTTVTVHLADVEDPSSKRHTPIENSISSGHCDPPCSSPGGMMEPRVSVSGLGSPHNCVEDREIARHGDGIGRDILERRPLPFSPAALLTGCSSTAASSVVSGDVFTSVAASARANACRSSTDTQEESGCGDAPRYVLLFPDEQDERLGHAQTSIATPSGSGQSKCMFKGDGNAEATFREEVKSSELRTPSRIQTRRLLPGVQLQGMDCDGCGASDPQKGRPAPETGFLPEICHFSPQHPWQPGSEVNQGYRAGADYGTSRVQQSLENCSWEESVDEGEQPRTTSSSSYGQDTQKRDSFLQSIDNRIASEPVDPTGTCGYNSTPETFRSGCIMRDQMLGVKPHLSHVSLTREGKHRGQQTHLRKTGVPTWSAEEDASLAELVSRKGFKWALISSQLTGAFGIPRTGKQCRERWFNHVNPEVKKGDWSAEEDAMILMLQNELGNRWATIAKKLRGRTENAVKNRFISLSNARLGYGRPKRDGSSADCFSNRRTGSGKSSGITGMPNLCQSVCSAGTTKKDSSESGNHFVMSVATKVFEFSDVAVDSGVSRPRQCTGTSPSCGHPSAGEGDPSHLKNTDVVGREQPIQRNNNESGKAAEQTAFSGVKTGTLSVSQDAVPVGRLVVASVGPQHIRRSFPTDETLPKFAAKEHNNQQLNDEREHLEQSNSTSEGSFLASAHEHADIARSDPDEDTLEPHQKRRRKRCAIAYQGEERGDSNGLDSIADRAEQAGNFQAMRKANTDNGKVDYLEPHRYEKLSPCEQVIQPSLRPACDHRGAPQNSVESGEQSPDAQRQLCNQGCRTSNRTVHSSVYSNEVESNELRGVFRLAEQSLPSQSGDPAWSTAGFQLSILPQKVEVHSRNKCDGQNVMYRCSPGSLPTTHQQTVFHYDRDSSRFPCAAKPAAASGAQGTIEENDGLVKEGPSMIVTGSSVEVVHCCSVSLRRRDRSLPSAQLWTSQETESDTNPSPNQQHESCHQYCKRHAAWCGKTDQFSKLTSSHQENSSGKDACLVSVSPTVTLDDLQKQSRGTVLSAKEEIGKPETWSHVVDNTYSKTDHQRASLCAENSSGCAEGSTELVRFSGGSVKSGSSMSVDCGNGNPDDCQDCKAEEIWRGEQRYAERGHSVESRGAGSVGRSTDLTITDSGSMPLCASPIGRPPADNDTLFLSDARCNVVAQLNHQDNSRISRLASCEEEFLACGGERLINASGGFKPDGGCLYRMQQAGACNTKLHRPVHSCSTIDSEQLEDLPSVEKAVGDRSFSSKRKGDIPPFAEWKKNDELRELYRGVSEAVSHGQPGDWNGSWPGISGRAHQTSSCFPDRVNASDRRELNSWRLHVSAAAELGSSHIWNSQSYASASVSRDKQREPPKNGLTGCDVPEYLGTSQSAGLPAANAHERGNFYGHDRCRPREGERVRWVGLQRNRKPEASVSSGASNSATTARPKDSTEPDEGNSEGVSTRRKDSGSTAATISRAVSLGMVTPSAACENSSSLTDTSPPLSHRPSFSFTHCCEETLSRCNSSNYLCPPATCHTSDDGRSLGPSREAQALRSLSLASGYGYPGIPAEATSFWQGSSLEHSIMEPQMVPSDDELRLWVHPRDAANWSQSTLKPVAVVSGTDAGDDQHKTPENLTPESGQAHRRDGHDMQRVQRCDDEGECPPTTVELTFPHSHSSDEMQDLPSKVQGNFLLRRELSDSLQHETAESVAGYGWMRIRNAGDIPNSKVPCAWEQCMPASERERGVNDHMSSEASRMSKAASSSFVPSSCTDAPVVRVGEDTTKSVCEEQQLCEGGNRGSLSPEATGFESLGPPLQLLLVDGYTPFEPVVEKVSQTMEQTLFPVPGQETDTRDEDGRYNCECLQNRQPPLHSGGLM
The following text describes a protein:
Function:
The RedD protein is probably one of several delicately balanced regulatory factors that contribute to the control of the biosynthesis of the antibiotic undecylprodigiosin (Red) in S.coelicolor.
Sequence:
MTGGGVLATMDPVRKLVRSQPKIGRHPVAAGQDGRDRHPIRSWECGERARTARTGRTVGRAADPSDHGPSLYNFGGCVEINILGPVSIDTSHSGGGIRAGKVRTLVATLAIDAGRAVSLADLVDELWGATPPDNVLNALQAHAARARKVLNERACPERAGGILRSVLGGYLLEIDPQCVDGNRFLRLVSQGAALLPADPTRAVELLETGLRLWRGPALIDAGEGRRCRGAAALFEERRLTALEDLISAMFLRGGEAQAIAMLQQLVAQYPLRERFCELLMVGLYRVGRQGDALESYRLARKRLDDELGVQPGALLRRRHAEILAQDPVLKVPSALWREPYAPADTSLLSA
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAPNKRGGPPSEETLAKLKGKKGQSSAPPPASKQKQAPANGEAAAAAEPCDFASGGMISKEEVEARGAGTDDPGDTYSRARFAWSEWRVFFTGLMFLTRLPVPPGIDHHPAFLVRSMMWFPLLGALIGGWGAVFFNAAAALWPPAAAGSLLPAAISTFSTVWLTGCFHEDGLADTFDGFGGGWGRNQILRIMKDSRVGTYALVGTALALQLKTSGLAAIAAAAPEAGGGVAGVAAALVAAHAASRWTSMVLIYVCEYVQDDEDAKRGMYNWFAQSTRLLTAPRLALGTLQALVIPLLALGPARAAIVYAVTAAVTVASGLYGNAVLGGVIGDYLGATIQVAEILVYCALSADWSRVAGSWEGAAPLLLLAAVAALPVIYCRRIVDWGSC
The following text describes a protein:
Function:
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MQFDSISDFFNMGGYAFYVWLAYGVTFFCLSTLIITSARQKRKVLIEIAKKMNREERLKETRSNKS
The following text describes a protein:
Function:
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Sequence:
MTAITISDQEYRDFCRFLESQCGIVLGDSKQYLVRSRLSPLVTKFKLSSLSDLLRDVVTGRNRDLRVAAVDAMTTNETLWFRDSYPFTVLADKLLPEMAANKRPIKIWSAASSSGQEPYSMAMTILEVQQKRPGLLPSVSITATDISASMLDMCRAGIYDNLALGRGLSPERRRVFFEDAGDGRMKVKDNVKRLVNFRPQNLMESYSLLGKFDIIFCRNVLIYFSPDMKSKVLNQMAASLNPGGYLLLGASESLTGLTDKFEMVRCNPGIIYKLK
The following text describes a protein:
Function:
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAPVDLKTHREEILKIHKEVSDPKSPTNWALFGYDGKSDVLIVVGKGDGGIQEFTDELNSGRMMYGYLKVIDPNTDLPKFVFINWQGEGVPELRKGACTSHVREVSNLLKGAHVSINARTEDDIDEETIKMKVSKASGANYSFHKEQKKDVAPIAPVGSVYQKIKPQVDIKPTLNSKFWEDLAKEESQRKENEKKMQAAEREKINKETKEREMQSSKLREQQEAERLKKIKEGQHTNTTTSAADDTQKFSIGKIKASLFEVEKKQEPPKQQPQPPRQKLQMPKMPKQEDEEPKKPVQQTIPSPVKIPAPPLQQPQNDDDDEEEEKREESIYDDTIAHADSTKNTTVTQNVVNEDIYDDTVPPRNESVSQQEENGEEIYDDTDAMHTTSTSHGVEEEYYDDAGPCTDGDLKCRATFDYQAADSDEISFDPGDIITSVKMIDEGWWYGKNSRGECGMFPANYVELIN
The following text describes a protein:
Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane. Mitochondrion matrix.
Sequence:
MDAFCSNEFHHAILYRSGFPDDQRSTVDALNNLQSNAMTLKIISNSGSEKEVNVHRTITCLNRIGLSVDDLDSLSIIHVSGTKGKGSTCAFTESILRAHGYKTGFYSSPHLIEVRERIRINGVPLSKEVFTSYFWTVYDRLEKSKEADDNYMPSYFKFLTVLAFYIFFCEKVDVSIIEVGIGGTYDCTNAIRNPVACGISSLGLDHTAILGKTIEEIAWHKAGIMKPGTSAFTAPQVDSAITVLQEQSNEVKPIGMYEAALQIVPPLSSYPGTEPKLGIDGEVQKWNASLAIQLANTWLEKNAKQSKTHNGDQQLQTGKGLPTASTFPLSENFKAGLQSCVWNGRYQMMKYDGATFYFDGAHTRNSIQARTAVEWFHNKSTIEATNIRGSVARILIFNLSGNRDSKTLLKPIINTNIDYAIFSPNILKENHSSPDTVNRNETTNAAMQRCNENLSAWMELNGLSNPTNSRICGSVNEAISVIKAIHKAKSLNYMNDKTIEKEKKYIHLQILVTGSLHLVGDVLQNDHISFIIVTPTKQLTAFFVQLNRPDNAVYVRIIHGSVFIILEKYQCYTLQPYALNVMQLRSTSLDAFSIFCVPLYL
The following text describes a protein:
Function:
Able to inhibit growth in several cell lines.
Subcellular Localization:
Endoplasmic reticulum. Nucleus.
Sequence:
MGCASCLPLQQPLWYEYYGPIRRVEAANAINAAIADNLNFDNAMTRVPIRKVTAPHIKVPGALNKPIVANLTDTTVTISFSTKAAGTMTLSANESSEALEFANALNQTLTFNRPTDEQWTIKFDFEDGEEVSCRIIKLNAKTPSSPIVADDKIVINGKISTINKVFREEDEGSDGGFNDGMCLICCSAESTVIAFPCRHCCMCSECAERFATMTIHCPVCRAIVTELIDCAPNQEQNPPPPP
The following text describes a protein:
Function:
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytosol.
Domain:
The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex.
Sequence:
MDALVAHCSARLLQQEKEIKFLTAEVDRLKNYSCSEASADLEKLREENLKLKYRLNILRKSLQAERNKPTKTMININSCLEEVFGCAIKAAYPVLENPPLIVTPSQQPKFGDYQCNSAMGICQMLKTKEQKVNPREIAENIVKHLPDNEYIEKVEIAGPGFINIHLRKGFVSQQLTNLLVNGVKIPSIGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESMCRLFEFAGYNVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQAFYKESKKRFDTEEEFKKRAYQCVVLLQSKNPDIIKAWKLICDVSRQEFNKIYEALDISLIERGESFYQDRMHDIVKEFEDRGFVQVDDGRKIVFVPGCSVPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSLHFQTVFGAAQMIGWYDPAVTRVSHAGFGVVLGEDKKKFKTRSGETVRLIDLLEEGLKRSMDKLKEKERDKVLTTEELKAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLRKAAHETEIILDHEKEWKLGRCILRFPEVLQKILDDLLLHTLCDYIYELATTFTEFYDSCYCVEKDRQSGEVLKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM
The following text describes a protein:
Function:
Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.
Subcellular Localization:
Membrane; Single-pass type III membrane protein.
Sequence:
MAGDTEVWKQMFQELMREVKPWHRWTLRPDKGLLPNVLKPGWMQYQQWTFARFQCSSCSRNWASAQVLVLFHMNWSEEKSRGQVKMRVFTQRCKKCPQPLFEDPEFTQENISRILKNLVFRILKKCYRGRFQLIEEVPMIKDISLEGPHNSDNCEACLQGFCAGPIQVTSLPPSQTPRVHSIYKVEEVVKPWASGENVYSYACQNHICRNLSIFCCCVILIVIVVIVVKTAI
The following text describes a protein:
Function:
May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).
Subcellular Localization:
Cell membrane. Cytoplasm. Lipid droplet. Note=Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent.
Sequence:
MSAPDEGRRDPPKPKGKTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAAHPEQTAPWTEKELQPSEKMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNIATGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTGMDTTKTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQNIATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQTALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGLLATTHGPEEAPRLAMLQNELEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
Sequence:
MGGNMEDVKMKCGLEIHVQIDTKSKLFCNCSTNYLDAEPNTNVCPVCLGLPGAKPLPPNKKAVEVAIMVAKMLGCKIVVDEDIYFQRKHYDYPDLPSGYQRTSTPIGVDGEFMGIGIHEVHLEEDPGQYNPSFGIVDYNRSGTPLIEIVTKPDIKSPEEAREFLKQLMTLFRYLGCLRGEGTMRADVNISIEYMGVQGNRVEVKNVNSIKGVYKVLKYELIRQKNIIKRGGEVKRETRAFLESQMITKAMRSKETAEDYRYIPDPDIQPIVISEKWVKEIEEKMPETPLAKKKRFVEEYGIDEEDAKVLVSDLDMAEMFEEVVKSLGVNKENVDLAVTWIRNELRRSLQYHKVDLYESGVKAEHIVELIKLIKEGVISQKIAKEIVDLLVINRGKKMPKELVEELGLTVIRDEDALVKAVEEAIKNNPKAVEDYLNGKKEALNFLMGQVMRLTRGRADPKRVIELLKERLDK
The following text describes a protein:
Function:
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
Subcellular Localization:
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Sequence:
MADQEFDIDAYFASQSEGKSVVASTPENQHCGFVAIVGRPNVGKSTLLNNLLGQKISITSRKPQTTRHRIMGVETDGNYQAIYVDTPGLHIEEKRAINRLMNRAASSSLSDVNLVLFVVEGTHWTADDEMVFTKLQKANFPVVLCVNKVDQVKDRNEVMLHMLELSKRMQFVDIVPISAKQGKNTDVLKKHVRDHLPKAVHHFPEEYVTDRSQRFMASEIVREKLMRFTGEELPYSVTVEIERFDYNPDTDGFHINALILVERIGQKKMVIGKNGEKIKTIGREARLDMEELFGRKVYLETWVKVKSGWADDERALRSLGYIDDL
The following text describes a protein:
Function:
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSSTQPNSSGTKKRTTTSTLHPGLHQYPAFYACYLLRSYYKGKRNERTYVGSTPNPPRRIRQHNGELKGGAVRTKYYRPWEMELICYGFPSKLVALQFEWAWNTPYKSRHLQAVKPTKEDSKQTELDSTGAIAGKAPTATQTKKPMFPRSTGNRVEVKLKVLRKMMTTLPWSQYPLKVLFFDESAYRLWLEQAKPPKSVSKQTSTTSDTLGVSVHPIEVTFRPEGVDGMRKDRHTIPSSPDDQRKPIEVHDEEAVLEDYEKIELIKKRCNGDLKCFLCDQSIDVEDHLSYVNCRSPDCFMSAHLLCLSKHLLDASTIDPLPPLTIGDEPQPSLPRVLPDRGRCPACSVDFRWGELVKGCYRRMPKNHTKAQISDADDEEEADLVFPYAEGDNQYPNLNDYGNTSVTEDEVDPNIRGSTTSSRGSKPAPAKKKQTSSRKPVTSRKQPSSKPTGKSRSAKPKPTKRTQRPIPEEDEDEPEQDFVKLMEELQVSD
The following text describes a protein:
Function:
Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis.
Subcellular Localization:
Secreted.
Sequence:
MERPPLPALLLGAAGLLLLLLPLSSSSSSDACGPCEPAACPPLPPRGCQLGETRDACGCCPVCARGEGEPCGGGGAGRGHCAPGMECVKSRKRRKGKAGAAAGGPVVSGVCVCKSRYPVCGSDGVTYSSGCQLRAASLRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL
The following text describes a protein:
Function:
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Has an essential role in mediating growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae.
Sequence:
MEDNRQQRLLERELYQIEQIRQLDSEELEIEEVENGHQSSDDDQIDERAFAGTSASGGYTFNTSLASMHSYLGEVEDTHNRLAFLDGGVILHVPLFYLEGVVLFPEATLPLRVIQPNFIAAVDRALRQVEAPYTIGVVRVFRDGDNGRIKFATTGTTAEIRQYRRLEDGSINVVTRGQQRFRLKRRWIELEGAPCGEIQIIEEDLPLRTPRDAFGKLTPLRNLSTANVSHSKLLDHDSDDSFESELSLTERRLHASAIKSSSHRNFFSESTSSDDESPVCEPQPLLHSRNNESIEDMSAKKYVSERPRRRAQREFRSVPGPRECPRAFWPYWVYRMHDSYCLAQRLSDMWKKIVGTPSMDALVRQPGLLSFHVASKIPVSESTRQELLEIDGISYRLRREIELLENFDQIKCRSCQTLIANRSDMLVMSTDGPLGAYVNPSGYVHEIMTLLKASGLALIGVPTEEYSWFPGYAWTVAYCATCEYQMGWLFTATNKKLKPRSFWGIRSSQVADDTH
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MMVKAIFKCDSDTNSSEVDTVSIKLQLSLVPNKISASGGKRGMVSYMQVSVATELIYYLIMGYVLFANVNSTETLGGIGGMSYTICFGQIAGFETVDLCFKQKLCVYSGLFMRFAWMVQPRNYLLLACHASNETVQMYQFSHWLKHQGFRRTGCSSTVPKSAKSWYVKNQKQESMVVDDAFSSKWRCSAKHKTFP
The following text describes a protein:
Function:
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.
Subcellular Localization:
Secreted.
Sequence:
MGTMAMMSSFILVTITLVIGREAWALENCLQEQARLRAQVHQLETRVKQQQVKIAQLLHEKEVQLLDKGEENSVIDLGSKRQYADCSEIFNDGYKRSGFYKIKPLESPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYKNGFGNFVQKNGEYWLGNKNLHLLTTQGDYTLKIDLADFEKNSRYAQYKNFKVGDEKNSYELNIGEYSGTAGDSLTGKFHPEVQWWGSHQRMKFSTWDKDNDNYEGNCAEEDQSGWWFNRCHSANLNGLYYTGSYTAETDNGVVWHTWHGWWFDLKHQWKKMLSEFRAGKSFASLGELLAPFENRNYLTGWGTWLPGSSEV
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSSNMQAMKQMRPALVSLTQQQARRRCFKLYRNCIRSIPHLIQHYNLSYNMSEMRNRFRSNFVEFEEVTEKNQLDRLAFIGETELFDAMSLLKTRSHVVNYFDTQPVNAKTISESEKLLNNFFE