lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MADEQLRAEELQQSVMMSEHQAEASTADGDVAMVNQVTITSDMSNIIAKPEPSEADEDQEMHDAQEENDHHDEEMGEGDDAEHSDQGSHDGHDDHDHHEDSGDEHGEEEEHDGEDPEGFDEDAEGDEGDSVHSEEHTSQQHLPSVEEDHDDDEDDDDEGVGAVKIKPGDTDHSESESEEEEDDHSSASSASVSDAESEDEVHWEDAAEHEPAGDEDDDDEGSEKGDSGLCMFCKQDEDHDPAEEFEEYLACAGCGDNAHQQCAREANALASDQALDAWKCPNCASEEGSQTAAGKNHEPTQVNGTETITHPTTRRASAPKLARDLLPPQKHTNPDSHSVFNQLVLDEDPMDGSRVLRKRKTSSVEPPEHIISLRKRRRNTVGTEEEPDESTAGYDEQARPTSARSLRIKISNPAAPVNIVKKTRSSILLRMRVDPTKLQQITSQPPKGDSKRSSRSARSGRSGRSGRSGRKTSGRSGRSRRAAAAADAMEPSTAPFASTSYTQPFYSFYDKETDELKGKPYGGILTDAEADTSKTLPQPEDRRRFDEAKQMAEEEWRQRLLKMQAEIEAPVKKSKKTAGPASQIECIEFGGWEIDTWYAAPYPEEYSRNRVLYICEFCLKYMNSDYVAWRHKLKCPAKHPPGDEIYRHGSISVFEVDGRKNPVYCQNLCLLAKLFLGSKTLYYDVEPFLFYVLCEYDQYGYHFVGYFSKEKRASSQNNVSCILTLPIHQRKGYGNLLIDFSYLLTRVEQKTGSPEKPLSDMGLVSYRNYWRLVMCKYLLEHCSGDPKEKKGLSIKKISDDTGLTPDDVISSLEGLRCLVRDPQTQLYAFRVDLPYCREYVAKWEAKKYVQLEPKALTWTPYVMGRSNATNFELGPALNAIAPREDDETKPTVEEGTVLNGNASQPDGLANQVEKMEIDTSAPTILESTEPNELGIIQPEVISPRSVLKTNGLFPNGSVHGSVHPNDDHDRKAKTEPDADGEDKENPDDWMAQYEGIPPTRFEVVPPVNTSRRGAGVDRIRNTVARLPAVRTNSGSAARPRNPRRTSGVRRVSSAIKPRSSSSSKRKAGGTGRGPGRWPKGTKKSDYGNAESGPGFPPGWLAKQKSLDSTTPKKEGEEGMRDTVHVTPTAESAAGYNMSGSGSGSGSRSANSSGANGNGEDAGSADNGDSFNGGGEDEQADITMKDDDN
The following text describes a protein:
Function:
Involved in pre-25S rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTTTKDNSGLAALFANSSGPRQKPQRAGKVDPVRDQQEDKMEVEDEEEDEEEDEEDEEEDEEDEEDEEEKEEDDDDDDDEEEIEEPVIKKSKKNKKSKEESADLEDQYMAKLAEEVAEEKPMVAETSAEEIKVDEPESDSEDEPELDVDEETKKKLEATNKELDKADYTIFVGNVSSEVITDKTVYNNFKALFAAIGTVASVRFRSISFSKLLPRKVAFISQQFHSKRDTVNAYIVFKNVKSVKGALTLNGSVFKGFHMRVDSVAHPGAQDHKRCVFVGALDFEEQEESLWEAFSSCGDVEYVRIVRDPKTNVGKGFAYVQFKDVNSVEQALLLNGKGINELSKSTTNKRKLRVSRAKSQHSQERAKQADMKNIRNAKTEGLSRDEKSHFGRAQSRLGKAGKAQLQSIVQEGLRAKKEDGKVNLARSKRRGVKPNKNRVEKPGQSRAEKRKAMFGTPTNGAPGAGGKKKRLTTRSQKFKQDGGVKKDGDAKKDGPKKERDGSKKGSKKN
The following text describes a protein:
Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MTLKTIRNGVHKIDMYLNAALDLLGGADGLCHYECRDGSKPVPRYGYRPSPPNGCGSPVFGVHFDIGIPSMTKCCNQHDRCYDSCGIMKNDCDEEFQNCLSKICRDVQKTLGISETVQACETTVGLLFDAVIHLGCKPYLESQRAACICQYEEKIDL
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of different purine nucleotides (GMP and IMP). Also hydrolyzes flavin mononucleotide (FMN).
Sequence:
MHINIAWQDVDTVLLDMDGTLLDLAFDNYFWQKLVPETWGAKNGVTPQEAMEYMRQQYHDVQHTLNWYCLDYWSEQLGLDICAMTTEMGPRAVLREDTIPFLEALKASGKQRILLTNAHPHNLAVKLEHTGLDAHLDLLLSTHTFGYPKEDQRLWHAVAEATGLKAERTLFIDDSEAILDAAAQFGIRYCLGVTNPDSGIAEKQYQRHPSLNDYRRLIPSLM
The following text describes a protein:
Function:
Testis-specific paralog of the ubiquitously expressed transcription and mRNA export factor e(y)2. Cannot functionally replace e(y)2.
Sequence:
MTINKETGTDPDPGYKPTLRSQDKAALKELLHTRLVECGWHKDIKEMIRNIIMERGVDNINRDQLAAQIVPQARALVPEVVKNEMMLRVHAALDK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVYKVLQKFNTSSSIEAFQPFLLLLKCLGLTPFFSNASNRRLLSVLNVIILLLIGTLYINGPCRQIRKDMLRFQSSPLAVNSRIFTYLMGTLVYHLTMLINFLHRHRLRDLFQAFVNIDRELQQVGVRINYRMHRFLITAGMVCFLSGIFVTSALVYAYKITVLNNQPNFDGRWYYNMFSFVYYNAAFPTITSYFAIVLWFLLVRFQRLAMAIRLASSTTTLPLIIKPKIHYRCIEQRACRMYFPTSPSAVGNPSEFAICSEKEQINVLKQIKILHDKLNDVVELVNYCFSVQGKRIGILVHKAINCSSSSAVINEVQCCEGANMMLPVCNVPCAWIILILYLSRQLNLFSQQLLHRSPVITCGLFVYDWTLWYTMIGATATYLIILIQFDVSFPNLVNVNATAVYRGST
The following text describes a protein:
Function:
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor (By similarity). May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Overexpression results in CFTR intracellular retention and degradation in the lysosomes (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Synapse. Postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
Domain:
The coiled-coil region probably mediates targeting to the Golgi, oligomerization and interaction with RHOQ. May also mediates association to membranes and interactions with GOLGA3 and STX6 (By similarity); The PDZ domain mediates interaction with ADRB1 (By similarity). Also mediates interactions with FZD5, FZD8, ASIC3, GRID2, CFTR, CLCN3.
Sequence:
MSAGGPCPAGAGGGPGGSSCPVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLRSELTETQAEKVVLEKEVHEQLLQLHSTQLQLHAKTGQSVDSGAIKAKLSVHSVEDLERELEANKTEKVKEARLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSGNSGASCKDSSGEMKMLQGYNKKAVRDAHENGDVGAAGESPLDDTAARAAHLHSLHQKKAY
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to use octanoate as substrate.
Miscellaneous:
MISCELLANEOUS: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIIIGKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKFTEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVVSALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEYKLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDCKIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY
The following text describes a protein:
Function:
Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 also functions in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway. Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.
Subcellular Localization:
Nucleus.
Sequence:
MVFRAPLDFISASRLLLPHFADAPPVLSRSRSPEHPPAGFLSLALPGLCFSATQIASVCETLEETGDIERLARFLWSLPVNTDGRDSISEHESVQRARAVVAFHTGCYRELYRILETHRFTRASHSKLQAMWLEAHYREAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRGLLREWYLQDPYPNPGKKRELAHATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHHRICPDSACTLSGGDSSERADGDTFLSVTDSDSDLDV
The following text describes a protein:
Function:
Essential for full virulence and survival within macrophages.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKNIILSTLVITTSVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSFISSLSYLYGDRQASGSVEPEGIHYHDKFEVKYGSLMVGPAYRLSDNFSLYALAGVGTVKATFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVVDVGYEGSNISSTKINGFNVGVGYRF
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MDVKIGSKRSHAPESSSSKKFCSFWLVKKNRFCLTVPSVDSDFCPSHVDKKVSDFQNTLENSQNFPVVNNINNNNNSNKDDTTTTATCQFWLKKKNRFCKAMPKNNLQYCVEHAVHLNIQFNRVRIPCPYDSNHSCYEDQLESHKKKCNSRPSLRPLFYEKGINIGDDEIVNDLKTSIKDMNVDDLNLLISRVTQLFDGTVHFLTILIKCHEVFSESLNDPNNGNNALKHLKQLSSLVGHMNDNNLLGAHTTYIEFGAGKGGLSHWVQLSNKSDDCRYILLDRSSVRYKARRADQGPTFERIKIDIEDLALGKVPQLQGSTHNIVGIGKHLCGRATDFMLRCLVNSVASIKTFNLFHHLTDGDIYKVLIDIGFSVKLSGIVLALCCHHRCDWNSYVGKEWFAEHRLDHNHFQMLVKMSAWATCGTKHVLS
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MPGSSGVAAMKKVVQQLPLECVKVSQAAADLKQFDLQNAQRDPLRTGVSSSTNPFRPQKVCSFLQ
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSYMKKDEDADQTMIKLDRTSVFQDARLFNSSPISPRQCRTLLTKIAVLVFTGEQFPTNEATTLFFGISKLFQNKDPSLRQMVYLILKELANTAEDVIMSTSIIMKDTAVGSDVLYRANAIRALCRIIDATTVQGIERLIKTAIVDKTPSVSSAALVSSYHLLPIARDVVRRWQSETQEAASSSKQSTGFLGFGGSSQAHAISQSNFMTQYHAIGLLYQMRSHDRMALVKMVQQYGAAGVVKSPAALVLLVRLAAKLAEEDSGLRKPMMQMLDGWLRHKHEMVNFEAAKAICDIRDVSDAEASQAVHVLQLFLSSPRAITKFAAIRILHRFASFKPHVVNVCNPDIEALISNTNRSIATFAITTLLKTGNEASVDRLMKQISGFMADITDEFKITIVEAIRTLCLKFPSKQAGMLSFLSGILRDEGGYEFKRSVVESMFDLIKFVPESKEDALAHLCEFIEDCEFTKLSVRVLHLLGVEGPKTSQPTKYIRYIYNRVVLENAIVRAAAVTALAKFGVGQKDPEVKSSVSVLLTRCLDDTDDEVRDRAALNLRLMAEEDEMANLFIKNESMYSLSTFEHQLVMYVTSGDKETFATAFDVSTIPVVSQEQALAEERTKKLTSATPTLKAPSTGPPKGAKANGVAEAATAAATQKYAEQLMQIPELKAYGTLLKSSVPVELSESETEYVVTAVKHIFKEHIVLQYDIKNTLPDTVLEDVTVVATPSEEDILEEEFIVPAPKLNTNEPGVVYVTFKKLEGEQSVPVVSFTNNLKFTTKEIDPTTGEPEDSGYEDEYQVNDLELTGSDYVIPTFAGSFDHVWEQAGANGEEVSETLQLSNLKGIADATEQLISTLSLQPLEGTDVALSNSTHTLKLFGKTVLGGRVAALIKMAYSTKTGVTTKITVRAEEGGVAPAVIASLA
The following text describes a protein:
Function:
Heme-binding protein which promotes neuronal but not astrocyte differentiation.
Sequence:
MGCLRLSFIVIVLAVGAGLYFRSTEDARVKEILNTVLKLTPKPIVDLFQSARDDSHNAKKQEKVTDNEVKSTNRIFSKQDLWDNYRGGDESKGLYLAFFGKVFDVSKGKEHYGPGGGYHFFAGRDGTKGFVTGDFSDEGLTDDIEGMDSKLMIGFDDWIQFYSSSYTYVGTVIGQFYDENGEPTEALKNANKLIAEAKQAKKQEDEENKILPMCNSESSAAKGSRVWCSTKSNSGGVERNWVGVPRQYHPPGATSPRCACVRTDDGKNRGDLDNPYLREYNGCHSTSDSCVIKQP
The following text describes a protein:
Function:
Catalyzes the transport of cholesteryl ester, and phospholipid between phospholipid surfaces (By similarity). Does not catalyze transport of triglycerides. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B. Required for normal expression of klf-3.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MFSSRIWLLLAVTVGVCLAVPDLDEIKKNLRKHGPDYYKNQPKMNENTVRLLKVDYWFRTESMIYDDIDNKEKDPSTVIAGNFSFETLHHDVEGGMLGRFTLTQCNTDNCGNPSPIYIAFRQGGNNAEHILKASDESDATWNFLYAIVNTIYTPAEYGEGDEQTVDTIYGRCFVNFGRPEDKRFRRIIEKCDLGYGTNFTKFEGIESVQYDQDVWYTQNTKVDADIIMVDAIEMLAFKSPLHEKYGFTLESRTHVEITNRTRVFVTSYCNDTVPSAKCAEQAFGAVRVGGKLYEHVKIAQEQSNKLTKLIGTYRRHLQDMGDSHICEKHSLLYSQIAQEARLAKRQDWEAAIQYPENDHVLSLIASALGGVGTAESITTAREVLLTASPDYLDDLLFGISQSSSNNEKWHKQLMYWLGSLDKKSEEYWKVANTIATVLNKRCEASTSSLNSCNKGKETIVNKFITDLTAGGVEVRVLEVLENIPIFGSYTFAKKFICETESEDVQKAALNVILAASKNLYETQLTHKLIKLFRNTCSQETPTSHSQLAIDILLKCVPDHQNVATLILRTETLNPDDQEKWHYLYKAIEASGNKDELKAEFWSRMRKFKVFRPNFLHRALQADSHVHWQEIADASNFQLFSTANTEFLQKSFKRSIFELSMKKGRKEHNLFSLSIDTEHLEQFVTGSASSRSGAPQGSVRIGVAGHKLPTHHIFKGSTDLLSTVWEADGRTHKAFEGHVPVRDVRLSVPLLSGLTLDVDSVGAISMRVLASAEVSLWNQRSNAKAEAYTSGSLHLTASLYHHSEPVRHVESTISALSTFTTDTRAIFETLPYDFCLRTSNSNVDINQKTVVQDQIGKHKKKTLNRKRVHPGVTYRLDDSTIRQCNSYLEQFRL
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MFAFPSNPDQATTIETPSDQLISQDIQGEEPTKASHNGVEAADSLTSNSPTESFTTCNVPSYVKLQAKLECSLQPQQVSTPVQHISNPLNNQNKITLNGFTSPHAATVVLFLTKAPIKQPNLFCTSSQSEDNLNTVQNEDESLMQLMQTMGLPTAFGSNKQNSNYEDQARKSHSGKKKKGKKKINRMKEEANEDDANLMTDNHHLESYEPAKKQTELEGWQEYWEKYGIQIVNTEWKDDCNVDWQDHCNQCYWRSFHLYKNWCDTGVWIQENDESINNASSTSLPVKTEAPDSGSNIETSKYNETPLPSISTQDQADLSIQCNEGDSQLQQDQNITDVDVCVSAVNDQVIRVNNPTDKVKTSSHSKSQSQQDQNITDVDVCVSTVNDQAAIHVNNPTNKVKTSSLSKKKKKPKSRNTKKQKMPLIEDFRIIYDALGLQIAPRVHCQNEKIHYLNEKLQKKFMNSDLKRPLVHYKFIDSDESSDYEQINQSPNSSMRTDEGEPVDFASNVPAVKPLNRKHYKYWVQRYRLFSKFDEGIMLDEEGWFSVTPEKIAQHIAERCRCSIIIDAFCGVGGNCIQFAKTCDHVIAIDIDPNKIKCARHNAKIYNVEHKIEFIVGDFLQLAPSLKADVVFLSPPWGGPTYLKADTFDIKTMISLDGYRIFAESLSISRNIAYFVPRTANVSQLTQLAGIGGKVEIEQNIINGKVKTVTAYYGDLIGQYLTDDG
The following text describes a protein:
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein.
Sequence:
MGSPDNKLSDLVDIVKSWIPWRTEPPNVSKDFWMPDHSCRVCYECDSQFTVFNRRHHCRICGRVFCAKCTENSVPAPSVEPRTGREDWERIRVCNYCFKQWEQGIAAVDSETKAPSPGLSPSPSATSLVSTKSSCTCNSGSSTVGSTLFSTGPYHRVNYSSGRSPCESAQMNAPTGQNNETSGMSTNPSSAMVDSSNHFGLCSYRSDDEDGGYGAYRSNSECRRYALAEEFSSAINIDKIGCVYESDKVYPDGDDIDSKHLSGSPLAENFDTQSVDGIKKFEEVNEQENTDQDEALAYYVDGTDAEPVDFENNGLLWLLPEPEDEEDEREAALFDDEDDDEGATGEWGYLRPSNSFGSGEYRSRVKSGEEHRQAMKNVVEGHFRALVSQLLQVENIHVGDEDGGESWLDIITSLSWEAATLLKPDTSKGGGMDPGGYVKVKCIASGRRCESAVVRGVVCKKNVAHRRMSSKKDKPRFLILGGALEYQRISNHLSSFDTLLQQEMDHLKMAVAKIDAHHPNVLLVEKSVSRYAQEYLLSNDISLVLNIKRPLLERIARCTGAQIVPSIDHLTSPKLGYCDVFHVEKFLEEHGSAGQGGKKLTKTLMFFEGCPKPLGYTILLKGAHGDELKKVKHVVQYGVFAAYHLALETSFLADEGATLPELPLKSPINVALPNKPSSIDRSISTIPGFTVPSSGKPVASQPINNFQKSNEVVISDSSSSANIDPPCQSVGVSSSSLSKGPHTTSKESASYSDEAIASLNSLSALRDDISYNSVSSISHAFCKDNKVDPKESLRTKTTSNGEAIMSDPFISLCQRLSEAAEQCDDPGGSNHADGSSVMAANHLGSRELQSSKQEISNKSEEMGSSKEEFPLSPSDHQSILVSLSTRCVLKGSVCERSLLFRIKYYGSFDKPLGRFLRDNLFDQSFHCRSCEMPSEAHVYCYTHRQGSLTISVKKLSEPPLSGEREGKIWMWHRCLKCPRTNGFPPATRRVVMSDAAWGLSFGKFLELSFSNHAAASRVASCGHSLHRDCLRFYGFGRMVACFRYASIDVHSVYLPPSKLEFNYDNQEWIQCEANEVSNRAEFLFTEMYNALRKISEKLSGPGSQDCGIKAPERNICIEELEAMLQKDREELQESLQEALCKELKAGQPVIDILEMNKLRRQILFLSYVWDQRLIHVCGSINNNIQEVMSSPIPKLGLKPVNSMEKLPEMNVSPKPSKSFNSCESALVETKPNIKMNQGGNAGVIDKSGGDHPEKGIGEDFNNRKEAEPSVSSSINTSENSDSPESGKVVQRARSEGELPIMANLSDTLEAAWTGKSHPASMNSKENGYSAPDSVAVDVSGAVNLDLGVLASDRGEGEVTRSPQPSLPAKKLESLEKSMSWANMPFPNFYSSFNKNSSFNPRKLSINDHSPVYVSSFMELERQCGARLLLPLGVNDTVVPVYDDEPTSIIAYALVSSDYHSQMSEGERPKDAADSTVSSSLFESVNLLSLNSFSDVSSEAYRSFGSGDDSILSLSGSGSLVSDPLLYTKDLHARVSFTDDGPLGKVKYSVTCYYAKRFESLRRTCCPSELDFVRSLSRCKKWGAQGGKSNVFFAKTLDDRFIIKQVTKTELESFVKFGPAYFKYLSESINTRSPTCLAKILGMYQVSSKHLKGGKESKMDMLVMENLLFRRNITRLYDLKGSSRSRYNPDTSGSNKVLLDQNLIEAMPTSPIFVGSKAKRLLERAVWNDTSFLALIDVMDYSLLVGVDEEKNELILGIIDFMRQYTWDKHLETWVKTSGILGGPKNTSPTVISPQQYKKRFRKAMTAYFLMVPDQWSPPTIVPSGSQTDLCEENNNSTQSGLLQQ
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MLFTVFDPSIPEQETILTDYDFNMIGHFRDNDQWFVNDSAMYNPLRFEGDIANSGLNSRSINTFLGDSPLFGIFGVQRNAVRQTYLKWEQARIPYTISSQYSSYSRTKIAEAIEEYRKKTCIDFSPKSAGDLDYIHIVPDDGCYSLVGRIGGKQPVSLGDGCIQKGIIIHELMHAVGFFHEQSRADRDEYVKINWSNVEAGLQDQFDKYSLNMIDHLGTKYDYGSVMHYAPTAFSKNGKPTIEPIEKNVEIGQRTGFSENDIYKINMLYNCPSFTTTMAPVESSKRVKSITKKVTSATASPISKKGEIGSSIGDKGDRGDNSILSSLISIHSGKEKCEDRRKDCEFLARAGHCESRFSVRFMTENCANSCRKCKNWCYRYTKKLRHRERRDGYLERFLRREEDGCVIGKHN
The following text describes a protein:
Function:
May be involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular Localization:
Nucleus.
Sequence:
MATTINTSNKNTVKLLDILKIIFENNKTNTISEETLLSLYYIFDQTIFASLELIDKELITKYVFQPSNRYFYVVEGRKGAKYMCLIQGDYCSCPSFNFSVLLKSDSVYCKHQISSILAEIISNVKVIEFDDSEYQSQILSIESLSFKTPTHKFQQK
The following text describes a protein:
Function:
Component of the KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as an allosteric effector that regulates the t(6)A activity of the complex. Cgi121 is not required for tRNA modification.
Subcellular Localization:
Cytoplasm.
Sequence:
MTPKFKNFKHDNSGQVETYLFEVISKYTMLEIKTKFGKLCIAKVKLASESIERALNLCNDNCQIVSAKCHEEVIFATILAIKAFSSGRNTAKTIKGEILLRLAGVKQIKDAIKIIGARKGENLIIYFGVSDPCSSLKDFISSLGLREEPLKPCDEDEVKRGFERAAIIEAL
The following text describes a protein:
Function:
Responsible for methylating the 5'-cap structure of mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSTDSYTPSQEPGSKRLKTGESVFARRGVSPSTGGVASAYGNESEKKPSWLQTNKSDIDGKYDKYGERRNAHTTTRDSRLDRLKRVRQKSAEREDVGHEGDEGDEDEGILPYIHLQAANPAIIHNEKQENYRTFQSRISNRENRDINSIVRAHYNQRTQQAKQQGSRVNSPIYKMRNFNNAIKYILLGNWAKHNPEELDLFSFLDLCCGKGGDLNKCQFIGIDQYIGIDIADLSVKEAFERYTKQKARFRHSNQNSNRYTFEACFATGDCFTQFVPDILEPNFPGIIERAFPVDIVSAQFSLHYSFESEEKVRTLLTNVTRSLRSGGTFIGTIPSSDFIKAKIVDKHLQRDEKGKAKFGNSLYSVTFEKDPPEDGVFRPAFGNKYNYWLKDAVDNVPEYVVPFETLRSLCEEYDLVLKYKKSFTDIFNQEIPKYFSKLNKNLIDGMKRSDGKYGAEGDEKEAVAFYIGFVFEKV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
METVGIIVGGGPAPGINGTISAATIEAINQGKKVIGIKGGFKPLFDGNLSCAMPLSVDDVSRIHTKGGSILRTSREHAERVKEKFPVLMETLKKLGIKYLITIGGDGTLFMANWIEREARGEINVVHVPKTIDNDLPLPGGASTFGYETARHWGVEIVKNIMEDARVSARWYFLTIMGRYTGHLALGVGKAAGATLTIIPEEFPEEKISFKKVADILTGAIIKRLSMGRDHGVVIMAEGLSEKFDPEELSHYEQLEKDETGRVRLSEIQLGRIMKNFVKKSLEDMGIKLTIVDKNIGYELRSADPIPYDIEYTRNLGYGAVRYLLRGGTGAMITFEEGHLRPIPFVELIDYRTGKVKIRKVDITSENYEVGRKYMIRLEAEDFEGERLKGLASVVKMSEKEFREKFFYVTT
The following text describes a protein:
Function:
Might mediate the very first reaction in teichuronic synthesis, i.e. the formation of lipid-linked N-acetylglucosamine.
Miscellaneous:
MISCELLANEOUS: The nature of the anionic polymer present in the cell wall of B.subtilis depends on phosphate availability. Under phosphate-replete growth conditions teichoic acids are present, whereas under phosphate-depleted conditions, at least part of the wall teichoic acid is replaced with teichuronic acid, a non-phosphate containing anionic polymer. The synthesis of teichuronic acid is accompanied by degradation of teichoic acid and reutilization of liberated phosphate for other cellular processes such as nucleic acid synthesis.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALIGLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWAQKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQRLGSGERRLRYDAEGKADI
The following text describes a protein:
Function:
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Subcellular Localization:
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MAVCEIKVHSADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTAKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDEDHSSPSVENMNEASSLLSATCNTFITTLEECVKIANAKFKPEMFQLPHPDPLVSPVSPSPVQMMKRSASHPGPCSSERSSCSIKEPASALHRLPQRRRRTYSDTDSCNDVPPEDPERPLHCSGNTLNGDLASAAIREESRLTAKTHSESEEPLPPFS
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNPLIAAASVIAAGLAVGLASIGPGVGQGTTAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV