lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation.
Subcellular Localization:
Cytoplasm. Nucleus speckle.
Sequence:
MAFSALEDGARGQAQRRRGCEHYDRGCLLKAPCCDKLYTCRLCHDNNEDHQLDRFKVKEVQCINCEKIQHAQQTCEECSTLFGEYYCSVCHLFDKDKKQYHCENCGICRIGPKEDFFHCLKCNLCLAMNLQGKHKCIENVSRQNCPICLEDIHTSRIAAQVLPCGHLLHRTCYEDMLKEGYRCPLCMRSALDMSRSWRQRDDEVAQTPMPSEYQNMTVDILCNDCNGRSTVQFHILGMKCNICESYNTAQAGKYRISIDQQ
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Sequence:
MFSGSNSYLGGNSGRQPPQQQPQQQQQYGGFQPNQGFQPQQTGFQPQQTGFQPQPTGYGNVAPLQPNFTGYPLQAQPTGYSQPPQSGFPGGQQQFNNAPQQQSFQTGAPPMPQIPQQFQQQPQQIQQAQPSPAAPVQQPQATGFAAMADSFKSASEPSKPRGRRASKGGAKIPSIRLSFITAQDQAKFETLFKSAVGDGQTLSGEKSRDLLLRSKLDGNSLSQIWTLADTTRSGQLHFPEFALAMYLCNLKLVGKSLPSVLPDQIKNEVSSMVDIINFAIEDDGPAGTNAPSFDSRQSTATPPTIQQPQPMPSNSALLTAQMTGFPGQQNNFSGGFQSQPTGFQSSMQTGFPGQQGGLQPQPTGFSQNMSNPQATGYTGPRPPMPPMPSNFSSNLSPAQTGMQGGMIAPLNSQPTGVPGQWGLVNAPATGLPNIDLLQSRMMPQQGREQGNFTTAGITGNAVIPWAVTKEEKTRYDSVFKAWDGFGKGFIGGDVAIEVFGQSGLEKPDLERIWTLSDHGNKGKLNMDEFAVAMHLIYRKLNGYPLPAQLPPELVPPSTRNFNDSIGAVKSLLHQESDFRKNSGATLLPQKTGLKKKVREKQVLLDAIDFKDENAADEDDALDRKDRREAEDLYRRIRRIQEDIDAHPDASLRNVDSGAERRAMKRQLQTLTDKLPDIASRVRRTERSIADAKLELFRLKDAKAHPGSASSIVGTGPGGAVTESDRLKARAKAMMQQRSAALTGKKIEISNDDLDAPKRLEEENLKIRTEKENNERMVQDVEESVRDFSRGLEDSLKDGGESSSSEHEKRRWEDGLGVEDEVKDFIFDLQRSSRSAKVRTDDRSREAPTETSRVSSAPAARSETPSSQPSSTPTPSAGTYSQYKTAEDRAAYIKQQAEQRMAERLAALGIRAPSKPGETTQQRLEREKNERAAKLKQAEEEDARREAERQARIAEEQGVAPHTPDQPKEITKKPPPPPSRKAARSDASERKFEEDRILKEQKSQIIATNELEDDAQRQENELAKEREAAQARVKALEEQMKAGKLKKEEEKKKRKALQAETKQQEARLAAQRAEIEAAQARERELQRQLEAIDDSDSSDDDEGPEQVTPQASTPTQGSQEFERKEASPPPPPPSVPVIVSPVPAAATTTSLPPPTPQVTSPVVSPPAETETRNPFLKKMAQSGDASAASTASNNPFHRLPSQELPAPAPIQVQPTGNRPSRVRPEEDDWDVVGSDKEDDSSDDEGPGAGGARHLASILFGTMGPPRPLSAMGNEATSAPHSPAAASPPVASPPPPPPMPSAGAPGGPPPPPPPPPPGMGAPPPPPMPPMGGAPAAPPAGGRPAGFLGEIQMGKALKKTQTKDKSAAATAGRVLD
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Miscellaneous:
MISCELLANEOUS: This bacterium is considerably more resistant to UV and gamma irradiation than E.coli; the E.coli-like SOS regulon model is not an appropriate model for DNA repair in this cyanobacterium.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MIQFLQGQVVTVTKNIQNRWFLILSVNGVGYELQVPHSLAQQWTPPPPEPQQVFTHLLVRQDQIALFGFGRLAERDLFGQLMGVTGIGAQLAIALIETLGLEGLVQAVVTGNVKQLCQTPGVGKKGAERLALELKTKLSQWHKLQMGTGETDSTLPTTALLEDLEMTLLALGYTQTEIQQAIAMVSQVPDVAQSEDPEVWIRQAIGWLSDH
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MLPKIYRSDPDIRKHQINTLKIFNDNVVEICEGHEYQISFKSDRHELCLHISLSNEFPNEKPLLTISPPIVHPWVNADSEVTSAPGLLNFSIHSDLGRVVQAIIREFERNPPPLKNDSNNITPGPGSTITSPTVPIRECERSSPSYCAVNNFSSPTHQKRLVFPELKKLSMDELEFLNNNSDRQLEFLNDLPPIKEQNKLLDDLIVQVEELAESNLSKQEQLSELRSEIEQKIGEVTKLAFENERLHMKYQDMSDKYSPFNIKEQLRLAAEKAESECESIADGFLKGEVDVDKFVNLYTKARSLCQARKTKEEKLSHQLESLSKAGF
The following text describes a protein:
Function:
Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.
Sequence:
MDIFKHHESQVQSYANHFPVLFGTAKGSWLYSQQGDAYLDFLSGAGALNYGHNNAVLKQALLEYIERDGLTHGLDMHSEAKAHFIQALQTHILEPRGLNYKLQFTGPTGTNAVEAALKLARKVTGRHNVVTFTNGFHGCSLGALAATGNQHHRQGAGLALSGVYRVPYDGYAGVDGLTLFETMLQDNSSGLDKPAAVLLETVQGEGGLNVASDAWLQRVQAICRAQQILLIVDDIQAGCGRTGTFFSFEPSGIEPDMVTLSKSLSGYGLPMALVLFKPEWDQWKPGEHNGTFRGNNHAFVTATRALEAYWANQDFQTHIAARSEQVTQALLQCLSRYPTLFSGLKGRGLMQGLACHNGDIARDIAALCFQKGLIIETAGAEDEVLKVFCPLTITEADLAHGLTIIERVLLE
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MGSAEEPESLQLRRPDPVPEEAARLPGLAAPRRRPDESCGARDRAMRNCCGEEPAVLGTGSTRGSGEKPGEKAPGRGAGMAAAGEMPGEPGDPRSQSDLSGSPQGAPGSAAGEEGGRQPAGVEEAATGASGKPCVKSSGARETPSLVEAEAATPTKPSATAVGEVEVPSSGKQDFVAPEKQETAASGKLETAASGKLETEASAKLETAASGKLQTAAPGKLESVASDKLESVASDELESVASAQVESAAPGKPESVVPGKPDSVIPGKGDSLTSKNQVSAASWKQDSAASGKQDFLASGKQDSLASGKKDFVASGKRDSAAPGKQEPAASGEVVSATSEKQDSAASRKQDSTSSRKNDSEVSGKADSMVSRKSDPAAPRKQDSAASGKGDSANSGKGHPTASVKGDSAAPGKGISPVFGKEDSANFEKKDSVSPWKQDSAASGKGDSVAPRKQDSVASGKGESTDPGKQDSAACGKGDSVASGKVDSTAPGKQDSAASGKGDSTAPGKQDSAASGKGDSTAPGKQDSAASGKGDSTAPGKQDSAASGKGDSTAPGKQDSAASGKGDSTAPGKQDSAASGKGDSTAPGKQDSAASGKGDSTAPGKQDSAASGRGESTAPGKQDSAASGRGESTAPGKQDSAASGRGESTAPGKQDSAASGRGDSTAPGKQDSAASGKGDSTAPGKQDSAASGRGESTAPGKQDSAASGRGESTAPGKQDSAASGRGDSTAPGKQDSAASGRADSTAPGKQDSAASGRGDSTAPGKQDSAASGRGESTALGKQDSAASGKGESTAPGKQDSVTFRKGDAVASRKQDSAALGKGDSAVLWKQDSAASGKGDSVASGKGDSVASGKGDSAAPRKQESVASGRGDTAASGKQVYVVSEKADSVAAGKQDSVASAKTDSETSEKQDSMASGKLDSVTSGKEDSATSGKQDSADSGKADSLGTRKQDSVASGKADSGASGKQDSVASGKGDSVASVKQDSAASGKADFVDSRKQDSMASAKADFVASEKGESVASGKQESASPEKGDSVASQQSDSASSGKLDSKASEKSDSTSSEKSDSTSSKKSDSTSSEKSDSTSSKTSDSTPSGKPDSTSSKKSDSASSEKSDSASSSKSDSAASEKSNFMPSERLDSAPVKKSDSPGEADATSPGKRDSGAAGKTDPVPSGGGGAEIPGSTPKEPPLGTEEPSRGSALQGSGWGLAPSAAQAPPSAVEPGGGQALEEAGRPPPILSAAKRAGGSEALPVTRRASRPPARPGPGAGAAPLDREGDSGVPPRPGPADGEARERAASEAVRASRAGPARTMSSSAKVPSLEVTSPQRDAGTQVDTRAPSVSVAVSPMTPQDGSGAGPAFSFQLGRGGPAFGGPGPKPSKDVEMQVSVPVETRSVATGPMTPVTPSPLASYPEVRVKGVPAPAPEEAPPEPVREVSWDEKGMTWEVYGASMEVEVLGMAIQKHLEKQIEEHGRQGALTPQGARACSVQGGPRPAEAKRPPGLFRALLQSMRRPRCCSRAGPAAE
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MTTPRSAPLYKLKSEDGQIFNVERGPMKFCAFINQKFIDHGVNDRNCERADPILVPFHSSIVQAVIEWLYHYQDNPLARRDSKIRYHDFSEWDKQFFNVESGVLFALLNASHALGVEDLMNMGCAAAAELIRGKSTEEIRKIYGIRSDEEQMEEALANGGEGTSAMTFTTDSD
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Sequence:
MRKVYVETYGCWLAKADAEILRQRLGLELASNVEESDVVLIYTCAVREDGEVRQLARIRDLAKSGREMIVAGCLARLRPYTIKSLAPGAALIYPQQVEGGPEREMKILPEFSGGVVYTVPLQVGCLGNCTFCATKYTRGGAGYVKSADPEEVVRKVKKAVAMGAREIYLTGQDVITYGFEMRWKRGWNLPDLLERILKEVDGEYRIRIGMSEPWVFEKFADQILDVVKRDRRVYRYFHLPVQSGSDKVLRVMGRKYTVDEYRELVRKIRRVLGETTFIATDIIVGFPGEEEEDFWATVKLAEELQFDKIHVARFSPRPFTEAAVMPKQVPDVEKKRRSKALSEISLKIAHVRNGLRVGTKDEVLIDEIDHGLVVGRASDYRQVVVKRGTHRELLGKFTNVRIVAAGPIYLYAEVIE
The following text describes a protein:
Function:
Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVLFVLYEHAAGYALFKVIAQEEVGALLPEVQEAVGDLALFGKLVKLVAFSPFKSGTNALDNVNCISEGIIHDDLKAFVEANVPTGKKKSKVLLGVADSKIGAAIQESLNICCDSGGVILEVLRGIRMHFDKMIKGLTGAMASKAQLGLGHSYSRAKVKFNIHRVDNMIIQSIALLDQLDKDINTFSMRIREWYSYHFPELVKIVNDNYMYAKVAKYIKSRKDLSEDKLEGLEDIVMDEAKAKAIYDASKSSMGMDISPLDLVNIESFATKVIGLADYRKSLHQYLISKMSSVAPNLSSLIGELVGARLISHAGSLTNLAKYPASTVQILGAEKALFRALKKKGNTPKYGLIFHSSFIGRADKKNKGRISRYLANKCSIASRIDCFSETPTSVFGTKLHEQVEDRLKFYETGEAPKKNIDAMKEAIDIFSQEKSNEELPESEKKKKKKKKDKKKKTEEETVPETVQTETPSARKKKKKEKEQEETMEEQQTEATSSAKKKKKRKVEDVEDTTEDEIEESINTSEKKKKKKKKKQTEED
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRELSNWQELLDSFTKTGVKQGKVNKIHQIKNSNADRIKEILQDEELRGVLIKWMNHQIKREQSDEATKYFREVGNRQFSLKDYSSCIETYTQSILSCPEESEVEKSLALANRSAALFQLELYEDCLEDIKLAIKKNYPSHLLPKVLIRKMKSLKKLGKEEDLQTTIEELESVMKHLQMTEKGKIQSDIRSVLLDNQDNENGPREALSEKEDLVFPFCGENSSFKGASSALNISHSKEKGRYVVANRDIKAGETLFVEQPNALVVLPDFQTSRCHHCTRHSSAKRYPCLACGKIWFCSDSCRQESSCYHNFECGLEAVLNSVGIAHLGARIVLSHGLDSVLAFLKDTDKVKKVPGIDGPYDTKSYQVMFHLVSHTERMAPEELYQYALTAAFLTLLLEQHSSFFQSASLESQYLVGGLILVHVCQMVSNAHAITELCLIDENNERQERIATAIYPSASLMNHNCDPTVINSFQGNTLIVRAIRNVRQGDEVFNCYGPHYRRMRRSERVEALEAQYSFTCTCDSCLDKNTEDFQDVIYSFSCPSCQGSLINPTGNNSSAQNQMALCRSCKTPQSYFTQLKADLEAVSLDARGTEAMDQGDIMGAIKLLTKCVQLRSKALFKGHPDLGKSADKLAQCYAFIGKYEECEKMLRISLTAVEHRYGRYSIEMANELQKFTDVLMELASGRNQRARDELVNYLEEAMLIYRIHYGPWSTSYKELQSKKVHLTSLLMN
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MRIYSRKMKTVCNKNLDVFDFKPDDPPRNAIEKYTFLETAASGKSISAEEINYVPSLDIDTINMNHMATTLVENPSVGMTAVTNHAFKVVKQRPLSSIELRTDLSESEVNAAATSASPSNNRLKSAMLDLLPSHYELDEAGGTGTDANGSMCDRSSSSSDVADDDAGPSSDNCIDDWEMDSEDTTTVVLYPDHVIYRGSYYTDCSISFTSGFVELEGSEVDGDERTLKCKWGIEDLLHITSHWYERVEMAMVKIHVLTKDTKHDKIVECASGTELKFAVIDSSWHERLEAIVSLNKTYKALWTSMLESEDTVVGHSGVSSSKYIPVFDRPFEEVVYPKGDADPVSLSKRDFDLLQPDTFVNDTIIDFYIKYLKNKIKPDESRKLHFFNSFFFRKLADPDKDPLDASKGGVAYQRVKKWTRKVNLFEKDYVFIPINYNYHWSLIVMCHLGEVATYEDEDVNESMNVPCVLHMDSLRGSHTGLQGLVQSYLKEEWKARQHEVSEDIASRFDNLRFISLELPQQQNMFDCGLFLLHYVELFLEQAPLHFNPFKISKSFNFLNEDWFPPAEASLKRVVIQKLICDLLENPNQEPSLSTADDDQRCHVSSLDTNAHKDTVVNLSLTHHQSSHDHKKTEIPSSSIQCADDDPNVTVKPSFSLKFNCATTFDECGSQDGSARDQETINNNHESLPEIQILGCDVSVEVVNGSRQLDSETDQPTLMDIMMPGSSFGFLDMQIDGSENASGLESDVQHATKKMRMTQPIVL
The following text describes a protein:
Function:
Oxidoreductase involved in biosynthesis of 3-hydroxyretinal, a chromophore for rhodopsin Rh1. Not responsible for the initial hydroxylation of the retinal ring but rather acts in a subsequent step in chromophore production. May catalyze the conversion of (3R)-3-hydroxyretinol to the 3S enantiomer.
Subcellular Localization:
Secreted.
Sequence:
MGMKFQKILVLAGIVIGFLSIIVVLAGTLLKNSVPNVLAPVERHFAFDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAGGQFGLLSRIPLLTTFQQKGINDWSFLSVPQKHSSRGLIERRQCLPRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQMRSFMAAAKPKNPDMLEIPRRYSKLTEALEEAQAQFAYKDWIFRRSLYNIRNGLRHSVVQQFLNPVIHHSNLRLLPDALVKRIQLAPSPFLQATSILVGIKDEENREKEFSIELLMASGIGDVSALKKLGIPAQHSLPLVGHNLHDHFNLPLFVSMGVTGPTLNQNTLLNPMTLINYLSSGSGPLGNFGVLGNVVSYGGLGAPPYGITFFGAGAIDESALMSISNFKGPAFRALFPRYYNSSQEGFVVISSCLQPKSRGSVGLLNRHMRRNPLIDPNYLSSEEDVACTISAIRSAVELVNSTAFAALHPRIHWPRVQECSNFGPFERDFFDNRPSDQYLECLMRHVGLGSHHPGGTCALGSVVDSQLRLKGVSNVRVVDASVLPRPISGNPNSVVVAIALRAASWILKSELQAGDSK
The following text describes a protein:
Function:
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5.
Subcellular Localization:
Cytoplasm.
Sequence:
MASSAQSGGSSGGPAVPTVQRGIVKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLARRAAATQPEAKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKDTNGENIAESLVAEGLATRREGMRANNPEQNRLSECEEQAKAAKKGMWSEGNGSHTVRDLKYTIENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDYYLVTVMLSGIKCPTFRREADGSETPEPFAAEAKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVAPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPRLEGENTQDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETVPAFSERTCATVTIGGMGRTLPPQMKPTFWRGLLSSRLPGKCSMATGSSVLKRQRNIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHIDGANLSVLLVEHALSKVHFTAERSSYYKSLLSAEEAAKQKKEKVWAHYEEQPVEVTPVLEEKERSASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKFVDGEWYRARVEKVESPAKVHVFYIDYGNREILPSTRLGTLPPAFSTRVLPAQATEYAFAFIQVPQDEDARTDAVDSVVRDIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYGDFRADDADEFGYSR
The following text describes a protein:
Function:
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
Sequence:
MNSITGPKWLIPMALMLGLAACSSAPKKTAGNGGNGAIKGVKVEGKGPAHVATGCPSTSPYAAAKEDPSTRGDYTAGGLYKPGVKDSTPDHVPNVACIPEPLVSNEPRSAVGNRSPYEVLGKRYVVMDNPGDYVERGTASYYGSKFHGRLTSNKEVYDMYAFTAAHKTLPLPSFALVTNTDNGQSVVVRVNDRGPFHDGRVIDLSYAAAVKLGITGKGTGNVEVRGLTEADNANLLAKRRSGIAPVTTVAAAKPAASSQIDSLVQQLPARGTTARPPATGTAAAPVPMGERWRYRVADSRQPGNADNFDAWMKSQGVRVATGKPTAATPRPAAAAAVATTVAVARTPDAPPAPRPAAPVIVAKPPTAAEAALGDILLQVASFASRENANRALSQLASAGIAGASVSDIVSGGRTLWRLRVNARDHANASEIAQRIAGLGFGRPQIVAN
The following text describes a protein:
Function:
Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity; Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC.
Sequence:
MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLASRELQSFYANLENVSLEELAFWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKAVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG
The following text describes a protein:
Function:
Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. Demarcates the prospective midbrain-hindbrain boundary (MHB) region in the neuroectoderm in early gastrulae embryos by repressing transcription of a number of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MPDMEYSDTFPSRKILKPVVEKQRRDRINRSLGEMRILLFQLTGNQKLQNPKMEKAEILELAVIYIRNVTRMKTHDPNKWASPAEKMYVSGFRECLDRTEDFISEISPKARAVFLDNLQTHLQQRLLLPQQVGGPGGDHEEDLMSNGSELSPIMDYSISRDELSLCTPSSSLGSESGSPPAWLPSSPPNPHEQPPLYIWRPWP
The following text describes a protein:
Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTDFEEPLSDEEKVRIAANFVTHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKLDGSEESVLITEHGDLGQGRFFDPRKRVSFRFDHLRKEASDPQPYEGESALRSWRDACDDALSAYVKEHYPSGVCTVYGKTVDGQQTIIACIEGHKFEPKNFWNGRCRSEWKFNISQSSAQVVGVLKIQVHYYEDGNVQLVSHKEVEESIVVTNEVQTAKEFAKIIENAENDYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
The following text describes a protein:
Function:
Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Note=Also released in the extracellular space.
Sequence:
MGQSPSPRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNAEYVSSTLSLRGGGSPDTPRGGGRGGLASGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCSRQGPTAPPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRAPGFLHCASFGDPHVRSFHNQFHTCRVQGAWPLLDNDFLFVQATSSPVSSGANATTIRKITIIFKNMQECIDQKVYQAEVDNLPAAFEDGSINGGDRPGGSSLSIQTANLGSHVEIRAAYIGTTIIIRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAIAIDTARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQTALDDARIFLTDLENLHLFPSDAGPPLSPAICLVPLLSALFVLWLCFSK
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MHPPMNSFITKFLDEDEDETMHSAADVEAITAALNRDIEGLGGEAANAMNQRAGTQVPFGLLLPEIQSQLNKDRAMQLQDLYNRLKSNRIDKNEFVRLMRTIVGEHMIKMALYKLQQRGQLSAKLNAPNSSAYVATSSIHRSSDPNTPPMENKSQQTRLLEHRSDSHGVQHMGFPQSSFSAYGHPSGNYHTGASPNTNMSSLSLQMSHGPVHPIRMQGGGPTHFTSNLPHVNLSSAAGSNAKTPPKKSTVAHKKPLEVPHVSSLSKKQKVCGAFSDQSIEQFNDVTAVSGVNLREEEEQLFFGFKEESHVSEATRKLVQEEEERLFLHKVPLQKKVAEIMAKCGVKNKSNDVERCMSHCVEERIHGLITNLIRLSKQRVDMEKPRHRTVITSDIRQQIMLLNQKAREEWEETHADADKLKRAAEVNKEQTTAANVAARAAVGGDDMLLKWQLKAERARQKQESGSNAAAASHPSLGVGLGLGLGPKLVPTSERNSTKDNPDTERSSGPVTANCGPLPRTVSVKDVMSVLTREIQMSRSTLIHHLYEQV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSLDQNSEKMSDPEPCGIKEEETEELIDVMVKEESEELSEDEEEHHVKSETETHSNTEHEKNTKSTDVVSFTCIQCGKSFTQKSDLRRHMMIHTGEKPYKCSHCDMRFSHSGNLTKHERTHTGEKPYHCTACGKNFSQSSSLRTHRKTIHKGMVEEREDVEKRRVRNKKKTPSKTESSVVMKRTPESFICGKCGMSFVRRYHLTLHMKIHFEEKPCKCSYCDKRFRDLKYLLRHESLHTGGNLFHCNVCGKGFTLSSSLRRHKKTIHNLDVKDEKVPRRVHKKEKSYLCSWCGKSLTQQSSLKIHERTHTGEKPYPCTLCEKSFICASHLRHHTMVHTGEKPHKCDQCSKTFVSASELKDHLRVHSKEKPFSCYLCEKSFNHRSNLRYHLKIHFGVKKHACLECGKTFVRAGELKQHQTTHTGEKSFTCPQCGKGFTQLSNIKKHMRIHSGERPHTCDQCSKAFLTASELRIHLRVHKKEKM
The following text describes a protein:
Function:
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for the translocation of bile acids (such as taurocholate), steroids (such as estrone sulfate), and eicosanoids (such as prostaglandin E2).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDVAHPEEVTRFSPDILMEKFNVSEACFLPPPISIQLILQLTWLDIGVFAALTAMTVLTIAIYLEIVCYLMDKVKCPIKRKTLMWNSAAPTVIAITSCLGLWVPRAIMFVDMAAAMYFGVGFYLMLLIIVQGYGGEEAMLQHLATHTIRISTGPCCCCCPCLPHIHLTRQKYKIFVLGAFQVAFLRPALFLLGVVLWTNGLYDPDDWSSTSIFLWLNLFLGVSTILGLWPVNVLFRHSKVLMADQKLTCKFALFQAILILSSLQNSIIGTLAGAGHIGCAPPYSARTRGQQMNNQLLIIEMFFVGILTRISYRKRDDRPGHRHVGEVQQIVRECDQPAIADQQADHSSISHI
The following text describes a protein:
Function:
Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). Unable to bind serine; In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.
Subcellular Localization:
Cytoplasm.
Domain:
'KIIK' region and 'KMSKS' region are required for cysteine persulfide synthase activity.
Sequence:
MLKIFNTLTRQKEEFKPIHAGEVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLRFLGYKLKYVRNITDIDDKIIKRANENGESFVAMVDRMIAEMHKDFDALNILRPDMEPRATHHIAEIIELTEQLIAKGHAYVADNGDVMFDVPTDPTYGVLSRQDLDQLQAGARVDVVDDKRNPMDFVLWKMSKEGEPSWPSPWGAGRPGWHIECSAMNCKQLGNHFDIHGGGSDLMFPHHENEIAQSTCAHDGQYVNYWMHSGMVMVDREKMSKSLGNFFTVRDVLKYYDAETVRYFLMSGHYRSQLNYSEENLKQARAALERLYTALRGTDKTVAPAGGEAFEARFIEAMDDDFNTPEAYSVLFDMAREVNRLKAEDMAAANAMASHLRKLSAVLGLLEQEPEAFLQSGAQADDSEVAEIEALIQQRLDARKAKDWAAADAARDRLNEMGIVLEDGPQGTTWRRK
The following text describes a protein:
Function:
Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE4 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Associates with KCNQ1/KVLTQ1 alpha subunit to inhibit potassium currents.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLRMEPLNSTYPSAAASSSPLESHVPSNSSGNGNEYFYILVVMSFYGVFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPMMSGLRSGQVPMMLNMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLPIQEEGADDELEETSETPLNDSSEGSSENIHQNS
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRSPCCEKEHTNKGAWTKEEDERLISYVKQHGEGCWRSLPKSAGLLRCGKSCRLRWINYLRPDLKRGNFTREEDDVIINLHSLLGNKWSLIAARLPGRTDNEIKNYWNTHIKRKLIGRGIDPQNHKPVTTKPAAAAINAPREEENPKTGFPASMQNDDVPMMAAMVGGAFRVVIAAGAEELSSSSSSSGLSEEKELLLVPQINLELSISPPV