lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSQHAMLRSNLRGGSEETPLHSGSCSLTGLARPLCSSGGLRLGGNPTGWLRSAGAGRAVPPNNLGRRPGGQLRLFSCLFPQPKMAAEVDFGDLELFEAFDHAEESIPKPVHTRFKEDDGDEEDENGVGDAELRERLRQCEETVEQLRAENILPLELKRKLNILTRPSGILVNNTKLDGPLLQILFMNNTIFILLLKIYGIMMRPSSVMLQEDHKVEESSDVQNNKEAFSVVGSVLYFTNFCLDKLGQPLLNENPQLTEGWEIPKYQQVFSHIVSLEGQEIQVKAKRPKPHCFNCGSEEHQMKDCPMPRNAARISEKRKEYMDACGETNNQNFQQRYHAEEVEERFGRFKPGVISEELQDALGVTDKSLPPFIYRMRQLGYPPGWLKEAELENSGLALYDGKDGADGETEAGEVQQNKSVTYDLSKLVNYPGFNISTPRGIPDEWRMFGSIPMQACQQKDVFASYLTSNFQAPSVRSNSKRASSQSSPSSPKKQKKEGSLAASPADMELDSDAEVPSNEAFQFQPPLPPGTPPPLPQGTPPPTFTPPLPKGTPPLTPSDSPQTRAASVTMDEDALTLEELEEQQRRIWAALEQAESVNSDSDIPVDTPLTGNSVASSPCPNELELPALEEKPSEKQMPDEAEVPDTCTKKSEVEQCSSPDSEAALLDQKEKEASAQVSCKDAPLGNGSVKSNCAISNGGGSQKLLHVDTSPATAPKIHSPIPDMSKFATGITPFEFENMAESTGMYLRIRNLLKNSPRNQQKNKKTSE
The following text describes a protein:
Function:
Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.
Sequence:
MSSQKENVPIPCGVELSIGDIEKSGYLRKLKTMRKKYFVLRSESITGPSRLEYYDNEKKFRLGGEAKRTVPLSACFNINKKSDAKHKHAIALYTRDDCFSLVADDEESKQEWLRVLLEQQRAGGDGKPVPAFEHVWQVTVKPKGLGSSRQLSGIYRLCLTTSTISLVRMNSENEGLEFSLSAIRRCGHSDCFFFMEVGRQSVTGPGELWMQVEDTVIAQSIHEASLEAMRSVKQQEEMRPRSHSSTMSSGNPGSDSKSHSASGSRRQSNTLGPSWRTRCDSMPVPNRAMPGSRSGSRSRGNSEGEDGQSKEEHAIASSSSPVSNLTNSVMRPRTCSEGGGGHSTVPRARSSLLKFGNKLRPRTSSEGEKGMKAPDSPTKTRGRFSIPSLTSRSSLSSGPIRPLSVHRMVAQPMSNSPPIPNSPLSESPQSYLDERYQSEGHSSDDHYFTRFGSSGGRSRTPDSPSHVSIREESQEANDEYMSMSPSAASKALPVPRNLAHSPHLHHHRLSPSQANRRASSPAISSPSSSPSLAPGIGGPHLQVPVPHHYHHHHHHHQQHQQHQHQHVYQNHQFLHVASSSSCASSAESSPRSLSPLVVDEPDSYMAMTPSNRSRPSSVNLAPSSSPASHITPSPSQRLAPSSGSGLKAPSNEDEGYMMMGPSPGSKRATPITITPQAGSTSAEPSTYMLMNPSANRPSPSSCNSPSLAWAPAPMSISPIGGGGGGAFTTNSLGKSPDKKHRNSAGQEDASLLKVGSSSHQRSHSEPVVDTYCNMEFEAKGSQVSHKACENNNINKKDVTQRHSMPPMEPKYINVNYEEKNEQLESSVQVTVDAPDCIEGNAMVRNIVESANKGLDVVKNGSPESGVNGEYMNMSFGKGRNGPKGITDLSKRQVPPLLLDPMTHPDSHDYINVQTDIREGVVKSSPRHSPVSPPSPSWLQRPVAEQLLRKSLEDLSFSQLSNSIPSRGSANSLTGVGSNRNSDTMSPGALSSHHSSRRSSQSSLSGERELNYIDVDIGQPASEKSGSSTPTLREKRSRSPFRRIPNEDKNCDQVNYSTIDFTKSEGLRSVTSTLRDARY
The following text describes a protein:
Function:
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit; Required for proper chromosome segregation during mitosis and error-free mitotic progression.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MACTIDFRCLDEGFGGKTYKRKRSEQQQEKDASMDIDAAEEIQTSKRQAVSSSENPNKPIFGKPTYDGVIAGKVSGRKWKQPKTQRSSAVRVSLKKSTFEERAQQKEIKKAYKERITELKEEIRKNKVEKREKKKEREKRKEENILKSGTKLQKITNPKTLKKLAKSKKRKLLKVVPDTAPKK
The following text describes a protein:
Function:
Involved in nitrate transport.
Sequence:
MASAVIMSFLAGALMLCALASSVEGGVLFSTLQKTLSVEAEIQSPVAPMGIARAGDDHLVISWVLQGDAAAREDAEYEKVSLKLCYAPVSQVERGWRKKNDDLHKDKTCTKAIATQKYTSGGNSTVWRVAKDVPGAVYFVRAYVLNANGTQVAYGQTSNEITVEPISGRHASIDVAAAIFSAFSIGSLLFFLALENVRGKRSSSK
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Zona pellucida. Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MKIDLRIWALFLLITGVSTQNTSVSVSCGSSHLTIAVPVALFGSGVVVDADELTLGTGCAVTAVHTNVLLLEYPLFACGATRKILPDSIHYRNILHYVPSAANGVIRSSGFSHPIDCFYPRSWNVSSLGLKPTWVPFTSTVVDRQRLDFALEVYDSSWSLPMPDPVYYLGDQINIQASVKKGSHVPLKVYVDECVARPSAESSVKYEVITNHGCFVDGQQSSSRFLATRVDGILRFQLDTFTFTGVSNNQIYLICHLKAVSTSATNHLNKACSYDRSTATWSSHEGADCSCCASRSGCNGRRRRRRKRGHHEKKGLFGETDIKLGPIELKTEQVNSSMLNASSTSEHDPFVATSVTSKTPRDARISANQVVNIIMREGVKEDSSGINLPFSTATLVIIVASLVIVLVSVLGCYCSSKRSHRGYHMGAARAPLGQPGAVPMAPAAVGSSGSAVSGESSTASKKPDGASLQ
The following text describes a protein:
Function:
Involved in the regulation of shoot branching by controlling axillary meristem (AM) formation. Functions in association with LAX1 to regulate the process of AM formation. Possesses transactivation activity in yeast.
Subcellular Localization:
Nucleus.
Sequence:
MVPARSLAHPHPHLVRRRRDHAAAAHGATARCDDDDDGVVTPRGPTRYMAQEPINHHQHQHDPPKQPPPREADDDHHRIQEREPLPPPTTTTRNQRLQLQLGGDGHHNHHHHHHQEVAGTSGSSSGGSSSNNGGGGTRDWLRLATGPASPGASAGSDHDLFPSTTTTAPAPQPPTPTPTPTPTPTPRHHHHDVLVLPGMPPPGSFLRPGPAMPGIPQASIPTHMLRAAPPWLPPWSPVAAPPPLLPFPHQHRAFYAAPPTTTPPASSGFDAIRVVLPPSAVAAAAGVWFVLQAAPLQGREPFLPQIPRSYLRIKDGRVTVRLLTKYLVNKLGLEDESEVEITCRGRQLLPILTLQHVRDSIWCRRDAVSPSAAPDIPTADHHQHIMVLQYGRRP
The following text describes a protein:
Function:
Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond.
Miscellaneous:
MISCELLANEOUS: Present with 7300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MCRFLIFKGKQPIRLSHLLTRPAHSIINQSFDSRLRLDRRRPMNGDGFGVAYYPLDTELSEDGPCLFKAITPAWNNQNLSTLAEKTKSDLVFAHVRASTYGVLSETNCHPFTYHSLCFMHNGGISNFKGIKRKLLNHIKDEYLNFIQGSTDSECAFALFLDTLDKLGYDPKKQDGDFGNVALRKAMLRTIDYIRDWTKEANKDEAHVEPSLLNFAVTDGSTVVVSRYITSKTDEAASLHFSCGSSFVETSPGEYRVERLDRNQDVIMVASEPLTFERGDWTAVPTNSILTIKKQTILLHPIIDEYYQEDPLYLRSSTLAESKGLMGSIPLAKAVEKNVPPLEREGRTRPPTAVAHIA
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MDISSQNNDVGITEGKKEEVWQVVEYVDAFLLSSGEHVLDCVHVLPNLLERMVNKYNSGRNKFGEEPKDDKSFLNVVDHIFKLSTCNTCNIALDQTSSILEKTMSLGPPKKKTRKKSFFFSSRSSLSAIPTKYPPLGQDQDNQEFPFNFSTQKISIFNKISTTMIATGYKIECCMAFANFRQGDFKIELQRFGHRNMKMEDVYKMPWESLEGEITTWNQVIWHCTTVLFNTEQRLYDSKLFKFLDMFMTLREDIVGEFYLEPCTKELAYETTTTKDMIIEAIVAMFCDLKNSIKNDNERIHVLNSAIHPLTRYVMNYLKYACEYKDTLEQVFEQGQGVNIEGIEIQNHKSVHEEVEDLYRDLALHYFFLMNNGRYIVQKVKGCVELHELMGANWCRRRQSGLRLYHKCYQRKTWSKLTRNKVSKQLVKKRFKCFNAMFEEIHKTQCTWMVSDEQLQSKLRISISALVILA
The following text describes a protein:
Function:
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity.
Subcellular Localization:
Cytoplasm, sarcoplasm.
Sequence:
MGLSEAEWQLVLHVWAKVEADLSGHGQEILIRLFKGHPETLEKFDKFKHLKSEAEMKASEDLKKHGHTVLTALGGILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISDAIIHVLHSRHPSDFGADAQAAMTKALELFRKDIAAKYKELGFHG
The following text describes a protein:
Function:
Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway. The enzyme has no activity with ornithine.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLKHFLNTQDWSRAELDALLTQAALFKRNKLGSELKGKSIALVFFNPSMRTRTSFELGAFQLGGHAVVLQPGKDAWPIEFNLGTVMDGDTEEHIAEVARVLGRYVDLIGVRAFPKFVDWSKDREDQVLKSFAKYSPVPVINMETITHPCQELAHALALQEHFGTPDLRGKKYVLTWTYHPKPLNTAVANSALTIATRMGMDVTLLCPTPDYILDERYMDWAAQNVAESGGSLQVSHDIDSAYAGADVVYAKSWGALPFFGNWEPEKPIRDQYQHFIVDERKMALTNNGVFSHCLPLRRNVKATDAVMDSPNCIAIDEAENRLHVQKAIMAALVGQSRP
The following text describes a protein:
Function:
Cytosine methylase that recognizes the double-stranded sequence 5'-GC(A/T)GC-3', methylates C-5 position of the second cytosine on both strands, and protects the DNA from cleavage by the ApeKI endonuclease.
Sequence:
MSRYSTISLFSGAGGLDLGFVQSGRFRIVFANEILLPAAVTYSRNLGLRLEVCGDEPRVEAQPGTIMACDVAKLDFTGLSGVDADVIIGGPPCQDFSIVRGPDWDRRGINVKRGRLYAHFVRALASLQPKAFVFENVPGLVSANRGLAYKVILEDFARLSIRWDEIKRIVSSNGNGGKVEGYEIVFTGIVDFSKLGVPQKRERLVIIGLRKDLAGGGFETISRLRARIDHVLSGKRWLLHRYPLTPIEVFEGQPLDRLGDKYKEVMLKWEGVWDEVGTERAFEWKRRVWDRLTFDIISDYLSFNGIKHADKQELEEALMQHEVLLKELGYYGRPVYSLKLPDSTTEPPYEGKAVVERMKRIPPDENHEFVRGTRWEVEGRGISLVYRRIHPLKPSYTVVAYGGGGTHGYHYDRDRATLTLRERARLQTFPDSFLFYGKKPEIRAQIGEAVPPLAAKRIAEALAEVLDAV
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate. To a lesser extent, also catalyzes the oxidation of L-serine.
Miscellaneous:
MISCELLANEOUS: Docking studies suggest a mode of interaction of TDH with 2-amino-3-ketobutyrate CoA ligase (KBL), the subsequent enzyme in the pathway for conversion of threonine to glycine. TDH is known to form a stable functional complex with KBL, most probably to shield the unstable intermediate and permit its channelling between the active sites of both enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEKMQAIMKTKPAYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEDLQVGDYISVETHIVCGKCYACKHNRYHVCQNTKIFGVDMDGVFAHYAIVPAKNAWKNPKDMPPEYAALQEPLGNAVDTVLAGPIAGRSTLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRKLAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVFLEFSGAPKALEQGLKAVTPGGRVSLLGLFPREVTIDFNNLIIFKALEVHGITGRHLWETWYTVSSLIQSGKLNLDPIITHKYKGFDKFEEAFELMRAGKTGKVVFFPHKG
The following text describes a protein:
Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in time-dependent memmory loss and the retention of conditioned behavior over time.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIGRKEKERERPYYRDPDDPEYIKDLQRPAVIKEDLSEMERRKRVQQILESKSFCHELEEVIRQECDTARTDPDHLQVLQKLSDLTVPQGNMSFGNLHTYGGNTIAIADLRGNEKYSKAERIQRNKLACLFRLADLFQWSQGIHNEISYRTNDEDNTFLMNPFGLLYHEITAATIVKIDENGKILDCGTLKAGVNQPAFLLHSAIYKAHPMVRCILHMHTAIVAAVASMKCGLLPLCKEAMVLGPVGYHDYQDIGDDDIQFDEIIANLGDKNVLFLRNQGFLVVGDTIEHATFLANNTVIACETQVRAARAGLDNLIIPEEKAIQRAFRNSRNTNSLKRNGTVDWRVGELEWESWMRVLDHANFQTGHVYRQPQLRPKSAMSTSMVNNNDVAVPPTTSAYGQIDETNLESVSAHRLALLRKEQERVRWMNSPNAYQKVEFLEYGADNPKKITKWVHDVNVPSASGTPVKISSVHQFSPASSNPKEFKEKQKAIKENNRLGTLSAGPQSQILDSVTYEDIALLIKPDNDGTVGQSSTADRAILIGTASKGIIDRQFQHHAQVYHQIYAPNPFSVETDADIKKYVDMVKAKNSQSAPVSARSGYSQYDEVEADTVSLMQGVREHKLSQAALSASDDGLNAGISPNNVRTSEESVNTSYMSQSVVFDCDHPSPMSISTEYPEKVKMTRFSSTQGTSEGNTTSRSCTTASEEEKPTKDEKKKKKKGFLSFMRKKDK
The following text describes a protein:
Function:
Oxoglutarate-dependent dioxygenase involved in the biosynthesis of strigolactone natural products, bioactive compounds promoting plant fitness and soil microbe interactions, but preventing shoot branching. Catalyzes the hydroxylation of (11R)-methyl carlactonoate (MeCLA) to produce (11R)-hydroxymethyl carlactonoate (1'-HO-MeCLA) in final stages of strigolactone biosynthesis, downstream of MAX1 and CLAMT.
Miscellaneous:
MISCELLANEOUS: The branching phenotypes of the lbo mutant can be rescued by exogenous treatment with the synthetic strigolactone analog GR24. However, the lbo and lbo max4 mutants do not respond to carlactone (CL) (Probable).
Subcellular Localization:
Cytoplasm.
Sequence:
MAPLPISSIRVGKIDDVQELIKSKPNKVPERFIREEYERGVVVSSLKTHHLHHQIPVIDLSKLSKPDNDDFFFEILKLSQACEDWGFFQVINHGIEVEVVEDIEEVASEFFDMPLEEKKKYPMEPGTVQGYGQAFIFSEDQKLDWCNMFALGVHPPQIRNPKLWPSKPARFSESLEGYSKEIRELCKRLLKYIAISLGLKEERFEEMFGEAVQAVRMNYYPPCSSPDLVLGLSPHSDGSALTVLQQSKNSCVGLQILKDNTWVPVKPLPNALVINIGDTIEVLSNGKYKSVEHRAVTNREKERLTIVTFYAPNYEVEIEPMSELVDDETNPCKYRSYNHGDYSYHYVSNKLQGKKSLDFAKILN
The following text describes a protein:
Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Sequence:
MIDIKILRENPEIMKENIILRNLDPQKYDVDYIIELDAKRRSLQKELDNLRAQRNKISQEIGKHQGEEREKLIKEAKILKEKIEELAKEYDNVEKELFSRLWQLPNFLSPKAPRGKDEKDNVEIKKWGEIKTFNFTPKDHLDLALLNDLVDFERGSKVTGSNFYYLKNEAVLLEFALFRLVIDTLLPEGFKLFITPDLARMEIIDGIGFQPRGPEAQIYRVEDTDLGLIATAEITLGGYHKDEILDELDLPLKYLGFSHCFRTEAGAYGRYNRGLYRVHQFSKAEIFIICRPEDSEEMHEYILGLEEKIFQKLEIPYRVLDICSGDLGAPAARKFDIEAWMPGRGEFGEVTSCSNCTDYQARRLNIRFRRVTGEVEYVHMLNGTAIAISRALIAIFENYQQEDGSILIPKALQPYIGISEIRPKK
The following text describes a protein:
Function:
May be involved in the limitation of water flow through the outer epidermal cell wall, either by direct modification of wall structure or as a signal instructing the protoplast to restrict water transport across the cell wall.
Subcellular Localization:
Secreted.
Sequence:
MARFFPLTLTILLFFIQRIDFCHTLVPANETFKFVNEGELGQYISEYFGDYRPLDPFTSPFQLCFYNQTPTAFTLALRMGLRRTESLMRWVWEANRGNPVDENATLTFGPDGNLVLARSNGQVAWQTSTANKGVVGLKILPNGNMVLYDSKGKFLWQSFDTPTDTLLVGQSLKMGAVTKLVSRASPGENVNGPYSLVMEPKGLHLYYKPTTSPKPIRYYSFSLFTKLNKNESLQNVTFEFENENDQGFAFLLSLKYGTSNSLGGASILNRIKYNTTLSFLRLEIDGNVKIYTYNDKVDYGAWEVTYTLFLKAPPPLFQVSLAATESESSECQLPKKCGNFGLCEESQCVGCPTSSGPVLAWSKTCEPPKLSSCGPKDFHYNKLGGWITT
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MSSVVLFAVSFILVLSWIAEGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKEFKQPLEKAKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVENDLMEANQAMFRILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASKWLSAAKDLLVDQPRKYHEVMGITKADVTLLLARSLIASGNVSIATDMLMRDFMFGEAGSALTVHFLRNKPKPSINLESWESDESFNQLCRSSSRRQMGESKPSRLHCRYNTITTPFLKLAPFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSDEIDPSRSADGAWLPHQNIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNSKTFSLETVGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFHGACPLISGTKLVMTRWIYELDQMFLIPAVLPPRSRNFSKSLPNPF
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDFLLGLVGADFVLVAADTAQIRSVVRMKSDLDKTMKLTDKTMMLLAGSVGACSNFGDLMAKNIKLNGIRNGYDHSPAECANFVRKSLADALRTREAYQVNLLLGGYDAHDGPELYYIDYFGAMAKVPFGAHGYGSFFTLATLDRHYKEGMNFEEAKDVMRKCIEEVRTRFIVNMPAFTVRVIDREGTHEVTL
The following text describes a protein:
Function:
Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon.
Subcellular Localization:
Cytoplasm.
Sequence:
MEILMYKRLPPLNSLKSFESAARYLSFTKAADELCVTQAAVSHQIKLLEXFLGIDLFKRKNRSLELTELGKAYFVDINKILRRLNEATERLLTLKTDPHLNISVPQTFGIQWLVPHLSEFNQLYPQIEVRLTGVDQDEGLLNKEIDLAIYYGLGNWQNLQVDRLCEENLLILASPELLAENPIIQPEDLKKHTLIHIHTCDNWQAMANHLQLDDLNIQQGPLFSHTFMALQAAIHGQGIVLANRLLALQEIENGSLQAVLPTNLPDPKSFYVVNHLDRLDDQKIQAFRQWIINSIKQEENE
The following text describes a protein:
Function:
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (By similarity). Acts as a key inhibitor of the NLRP1 inflammasome.
Subcellular Localization:
Nucleus.
Sequence:
MYRGKRVKLEDETEGSWKSFAAVRMTAVDDISDSTEVVEMEDVPSQFFVEKHSWDGLRDIIHNSRMYSGMVINKAPHDFQFVQKHDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKIRKEALLVLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDYHAQSGLFLFQASNSLFYCRDGGHNGFIQAAPMKPMEIKTQCSGIRMDPKISPGDPSFIAFINNNDLWVTNIETAEERRLTFCHKGLNNVKEDPKSAGVATFVIQEEFDRFTGYWWSPAATEDADGGKTLQLLYEEVDESEVEIIHVPSPALEERKADVYRYPRTGSKNPQISLKLAEIRTDQQGKMISAQNKELVLPFTTLFPGVEYIARAGWTKDGKFAWAVLLDRSQQKLQLVLLPPALFIPVSVDDPQWEEHVEAMPEGVQPFIIYEEITDIWINVHDIFYPFIQTSNDKISFLWVNESQTGFCHLYRITSLLKPGCHQWSREYSPSEDDFKCSTEEEVALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYESPGEIVRLTKPGFSHSCSVSQNFDMFISHYSNVSTPPCVHVYKLTGADSDPLHKEPEFWASMMEATGCRPDYIPPEIFSFPASSGFRLYGMLYKPHNLKPGKKHPTILFVYGGPQVQLVNNSYKGVKYLRLNTLASLGYAVVVIDGRGSCQRGLKFEGALKNKMGQVEIEDQVEGLQFVAEKYKFIDLSRVAIHGWSYGGFLSLMGLIHRPNIFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQQGYEAGSVALHVDKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEIMLLYFLQQHL
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MGKPLGPTGEFFRRRDEWRKHPMLTTNLRTAIPGLGTALVAFGIYCVGEAVYKKFNTPSDSHSQH
The following text describes a protein:
Function:
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair.
Subcellular Localization:
Cytoplasm. Nucleus. Note=By SDS-PAGE, 2 isoforms have been observed, the shorter seems to be predominantly nuclear and the longer is mostly cytoplasmic.
Sequence:
MFSAGAESLLHQAREIQDEELKKFCSRICKLLQAEDLGPDTLDSLQRLFLIISATKYSRRLEKTCVDLLQATLGLPACPEQLQVLCAAILREMSPSDSLSLAWDHTQNSRQLSLVASVLLAQGDRNEEVRAVGQGVLRALESRQPEGPSLRHLLPVMAKVVVLSPGTLQEDQATLLSKRLVDWLRYASLQQGLPHSGGFFSTPRARQPGPVTEVDGAVATDFFTVLSSGHRFTDDQWLNVQAFSMLRAWLLHSGPEGPGTLDTDDRSEQEGSTLSVISATSSAGRLLPPRERLREVAFEYCQRLIEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRSLSCLKALHGRVRGDPASVRVLLPLAHFFLSHGEAAAVDSEAVYQHLFTRIPVEQFHSPMLAFEFIQFCRDNLHLFSGHLSTLRLSFPNLFKFLAWNSPPLTSEFVALLPALVDAGTALEMLHALLDLPCLTAVLDLQLRSAPAASERPLWDTSLRAPSCLEAFRDPQFQGLFQYLLRPKASGATERLAPLHQLLQPMAGCARVAQCAQAVPTLLQAFFSAVTQVADGSLINQLALLLLGRSDSLYPAPGYAAGVHSVLSSQFLALCTLKPSLVVELARDLLEFLGSVNGLCSRASLVTSVVWAIGEYLSVTYDRRCTVEQINKFFEALEALLFEVTQCRPSAALPRCPPQVVTVLMTTLTKLASRSQDLIPRASLLLSKMRTLAHSPATSSTHSEEGAEAIRTRATELLTLLKMPSVAQFVLTPSTEVCSPRYHRDANTALPLALRTVSRLVEREAGLMPG
The following text describes a protein:
Function:
Probably involved in maintaining Golgi structure.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQVRLKDVVRAYKSLLKEKEALEASLKVLSASQEADDAGLPAVQSPGLPLAESVDDRCSTHSEDSTGTATSLDTTASLTSTKGDLGMEEERLAIGLPPPKSEETSGSESGISSSSGDVPASGGGEIDKRLHQLKTQLATLTSSLATVTQEKSRMEASYQADKKKMKQDLEDASRKAEEEKSRLEGELKGLQEQMAETKARLITQQHDRAQEQSDHALMLRELQKLLQGERTLRQDIELQLEETREALAGQAYSANQVEGFELQIKQLTGEVEELKHELQALREEKNQPDPRLEELQEEAAHIKNHFQALLQQEMRKTALAEEQLLQYSKMEEQRVAALENQVSEVSELLGTYEKAKQKDQLAIQKLKDRLLQLDMENKTLALAASSRSPLDSHNEETSLDVNVLKDKMEKLRRLLQIAARKSQVSLNMEKLCDLDLLTNSDAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKTTKDGNLAKELEDSQEQLAELKEKYISLRLSCEELERQHQQEAESWKQELAQLQQAHRQELEKSQLDFRDRTLKLEEELHKQRDRALAVLAEKDLELEQLRSVALCSGLQGHKASVSQGSTGDLSDSTPDSLTQALHLAASNEPTFFLYAEQLARKEVEITSLRKQKHKLEVEVHQLQDRLIVEGEQHREQVSALQSHIEKSIRDQSREGANLEYLKNIIYRFLTLSDSLGRQQTLTAILTILHFSPEEKQVIMKLPISSIWWPSGKR
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MPSLAGIVSSAATAFLLLLVLVPKNGSVALAAEMCYCYERSAVDGEAHKLTKTVALLAVGPIELQIKKTVSTVSGCSGAAPTSSKPPPIPADTRAPTPPAPPAADKRCLSWPAKAWCCWSLAVAIVIAFFAVRLGTFLVPSRIDPLFTTDGEPADGNQHTTIVTVAAHVPAGSWERRRERRPRRMPRTQLQEMLMIDTNNGNSRLDGNSELFYCPMCIKTVPILLKSSFGSCVDHAFCSNCVAAYIAVKLRQNEARVECPDCDYGLLPMPMVRYETPHIDRTIITDGTEDLPVDGNDVGDGKRFYCAKCMHVVACACIRPSFTSCAHDFCSSCVSRRLRGRLDDGKHFYCTKCMRVVPCACILPSFTSCAHDFCSSCVSPKLELEGLRRRAGKLPWHHHPTDPLPMDMVQFTGGNGDLPVDGELFGCAICMETVPSTLKFIVNSCGHAFCSSCVAQYITAKLDDKVARIKCPKPGCEDGAVDPGSCHGIIPTDLLDKWGLLLCELAVGAKRIYCPHRECSALLLDDGEAGAAAIAEAECPHCHRLFCARCAVPWHDGFVCEEFQKLGQDERGREDLMLRRLVGREGWQRCPKCQMFVEKSEGCNYIKCRCGYSFCYRCGSELSAQNHYCNKCKR
The following text describes a protein:
Function:
Involved in the translocation of tetra- and pentapeptides across the cellular membrane in an energy-dependent manner. Also involved in transport of glutathione derivatives and metal complexes, and may be involved in stress resistance.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGEIATEFTPVMDDDDDRCVVPEVELTVPKTDDSTLPVLTFRMWVLGIGACIVLSFINQFFWYRTMPLSITGISAQIAVVPLGHLMARVLPTKRFLEGTRFQFTLNPGAFNVKEHVLITIFANSGAGSVYATHILSAIKLYYKRSLPFLPAFLVMITTQILGFGWAGLFRKHLVEPGEMWWPSNLVQVSLFGALHEKEKKSRGGMSRTQFFLIVLVASFAYYIFPGYLFTMLTSISWVCWLNPKSILVNQLGSGEHGLGIGSIGFDWVTISAYLGSPLASPLFASVNVAIGFVLVMYIVTPVCYWLNIYDAKTFPIFSSQLFMGNGSRYDVLSIIDSKFHLDRVVYSRTGSINMSTFFAVTYGLGFATLSATIVHVLVFNGSDLWKQTRGAFQKNKKMDIHTRIMKKNYREVPLWWFLVILLLNIALIMFISVHYNATVQLPWWGVLLACAIAISFTPLIGVIAATTNQAPGLNIITEYVIGYIYPERPVANMCFKVYGYISMTQALTFISDFKLGHYMKIPPRSMFMAQVAGTLVAVVVYTGTAWWLMEEIPHLCDTSLLPSDSQWTCPMDRVFFDASVIWGLVGPRRVFGDLGEYSNVNWFFLVGAIAPLLVWLATKMFPAQTWIAKIHIPVLVGATAMMPPATAVNFTSWLIVAFIFGHFIFKYRRVWWTKYNYVLSGGLDAGSAFMTILLFLALGRKGIEVQWWGNSGDRDTCPLASCPTAKGVVVKGCPVF
The following text describes a protein:
Function:
Hydrolyzes ribosome-free peptidyl-tRNAs (with 1 or more amino acids incorporated), which drop off the ribosome during protein synthesis, or as a result of ribosome stalling; Catalyzes the release of premature peptidyl moieties from peptidyl-tRNA molecules trapped in stalled 50S ribosomal subunits, and thus maintains levels of free tRNAs and 50S ribosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MIVIVGLGNPGRKYAKTRHNVGFMVVDELARKYGLVFKEKNDYYITEWRLENKDITIIKPTTYMNLSGTAVKKVVNEKILKNLPESLIVIHDDVDMPLGKIKIKKNGSSGGHKGVQSIIDSLGTKDFIRIKIGIGKNPYQDVSEYVLSPFTSEQRAKIQEKISEAVESIVVIINEGVNKAMNIYNRL
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MSWGLGWKRPSEIFRLTLNYGTEESEDDLNRTSTSSSGSFSSSSPTSLSSPPHDQDPGLRIDLDWTVGDDEDQVALRLQSQLMVALPLPQDCVTVDLNVKEGENVGVEMKVVKRREPLRGMILSKGGSGQQSDGIGILTRLLRSNLVTDGVVSTCGEHWRNVTLLSLCGCCLSVLPAELIGLPLLEKLYLDNNRLSVLPPELGELKALKVLSVDHNALVSVPVELRQCVGLVELSLEHNKLVRPLLDFRAMAELQILRLFGNPLEFLPEILPLHKLRHLSLANIRIVADENLRSVNVQIEMENSSYFGASRHKLSAFFALIFRFSSCHHPLLASALAKIIQDQGNRIVVGKDENAVRQLISMISSDNQHVVEQACSALSSLSGDVSVAMQLMKCDIMQPIESVLKSVAQEEVISVLQVVATLAFASDTVAQKMLTKDIHLTFQFVFDQVQRLALLAVGNLAFCLENRRILVTSESLRDLLLRLTVTSEPLVNKAAARALAILGENENLRRAIRGRQVAKQGLRILAMDGGGMKGLATVQILKAIEKGTGKRIHELFDLICGTSTGGMLAVALGIKLMTLSQCEEIYKNLGKLVFAEPTPKDNEAASWREKLDQLYKSSSQSFRVVVHGSKHSADQFERLLKEMCADEDGDLLIDSAVKNIPKVFVVSTLVSVMPAQPYVFRNYQYPAGTPEVPMPNSESSGVTVLGSPTIGAQVGYKRSAFIGSCKHHVWQAIRASSAAPYYLDDFSDDVNRWQDGAIVANNPTIFAVREAQLLWPDTKIDCLVSIGCGSVPTKVRRGGWRYLDTGQVLIESACSVDRVEEALSTLLPMLPEIQYYRFNPVDERCDMELDETDPAVWLKLEAAVDEYIQTNSDAFKNVCERLLLPYQHDDKFSENLRNHQFPKPKVANSDGSSPSLGWRRNVLLVEALHSPDSGRVMHHARALESFCTNNGIRLSLMLGASGIAKIAPATTFPSPFTSPLITGSFPSSPLLFSPDFGPHRIGRIDMVPPLSLDGVQSVKNAASPPRSPSGRRQLSLPVRSLHEKLQNTPQVGIVHLALQNDSVGSIISWQNDVFVVAEPGDLANKFLQSVKFSLLSMMRSRRRKVPSFFANISTVADLVRYKTYFQVGNVVHRYIGRQTQVMEDDQEIGAYMFRRTVPSMHLTPDDVRWMVGAWRDRIIICTGTYGPIPTLIKAFLDSGAKAVVCPSADALEIPLTSTHGSEEFHVLENGRFEIGEEEAEDEEAEPVSPRSDWEDSDLEKNGERATGFWDDEEDELSQFVCHLYDSIFQEGAKVDAALRNALASHRRLRYSCHLSGIQ