lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MAIAATIIGVAGNVVAALMFLSSILTFIRIAKKKSTESFSSVPYIASLLNCILWVLYGSPINKNATLVVTINGLGTVLNVIYVLLFLFYARKSPKALKRASLYTFSCLAIMAAVGFGISLGIHSKDTRITIFGVLCIVLNIAMYWSPLSVMYRIFKTKSVEFLPFYLCLTVFINSALWFAYALLKHDIYILVPNVLGLAGGAVQLFCHYIYYKPGNLLTWQVPDEKEAEESESPDLESGIELPKQNGKFVDVALNTSTMATQS
The following text describes a protein:
Function:
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAFATRRSLRRTRGKASAWWPTPRSCRESKRLRIRSAISNTMKSLRGAGWAPAPARAQRWSAGTPRKAPITDGRSSTNHSTTSSPATRCTNSSRRPRSPMATRSPQRPPPRSAVHRPQQGSVSVPSMITTRPMRTRSPSRMVTPSSTCSRSTTVGCTARWSARATRGCCQPTTWRPSEGGVGPNTPPPPPLHHHHHVAPVRARLSPPASLTSAGAASRHLGFFVFLQPPLVSLANVAFCSRSVGTEGSVCEGCRGLWDQMFLPLPSSSLPQGMGGAHTHTHTHTHTHTHTPGCAPSSLRWECKGREEQNHFLRTKHPTSWGLGGWGCWGDQLAAPALRCSGSARPIASPGSLFAVPIPTALPQSSVLQTRRVFVVKILKEKSFLGIRSGSRQPWERLLLLFGGPAASFCIPG
The following text describes a protein:
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKGVGTWESAMEVAEEQQQQQKKRGGGFQSFGLEKPLLDGILRLGYNVPTPIQRRAIPPMMQGNDIVAMARTGSGKTAAFLIPMLHLLKAHSKIVGVRGLILSPTRELSMQILRFGIQISKFLDLRFVALVGGNSLEQQFEMLASNPDIVVATPGRILHIMEEASLQLSMVKSIVLDEADRLFELGLQPQIVAIMQKIPESCQRSLFSATMPSVLAEFTNAGLHNPVVLRLDAEMKLSDKLKQSAFFVRNDEKIAALIVLLKKVIGIEASDKKSESAEKQALVFVESKFHVDYLEAIMEAYHISCSAVHGQMDQEGRRNAVRAFAKRETSVMIVTDVAARGLDLPLLDNVVNFSFAPTPKLFVHRVGRVARAGRSGAAYSILTFEDFPHYVDLMAFLNRPLQCRKEPGDLLFTADDGCYGRMPEDALQLELDFIRRLVQNDVELKGMTKVVENAHKKFARTKKKATHDGIQTARQSEYQFDSTPLHPIFVERLEKKEIAADEARVGLKRFKAKESLLEIVHGEKMMEIKKPVTVQSLWREQRQRGEDKEGSEKVDTGSDKKQGKHESENCVSMVARKNGAVKGSSTMGRKLSLAESLLLKAQERKKREREAVNGEENDDVDGITVFPARAAYHSNSSAGAIGGMECNSDKYRDREFFMEDVKRNTIEDVHYSVKDATFDIGADTAQEAQQRRQVYAWSKKKNRYVRMNVNDAKALLRGVKNEAGKAVNFKTKLKTYSKWTKKSNLRIQDAGEEEDLGPLRQARDAQRQNERGVGDEDDGFDETEEVDISNPNQGKKLRIGRKLRRLPKDGHVRTFEEMALMKRKAAKEKARLERKKQKGKRKR
The following text describes a protein:
Function:
Catalyzes the reduction of both Delta(1)-pyrroline-2-carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate (Pyr4SH2C) and cis-4-hydroxy-L-proline (c4LHyp) as substrates, and might be involved in the metabolism of c4LHyp, a compound which is generated by the hydroxylation of free L-proline in bacteria.
Sequence:
MIRMTLDEVRELAVRILRRHAFSEAHVQAVADTLVAGERDECASHGIWRLLGCIATLKAGKVSADAEPELHDIAPGLLRVDAHGGFSQCAFRLGLPHLLEKARSQGIAAMAVNRCVHFSALWVEVEALTEAGLVALATTPSHAWVAPAGGRKPIFGTNPIAFGWPRPDGPPFVFDFATSAVARGEIQLHERAGKPIPLGWGVDEQGEPTTDASAALRGAMLTFGGHKGSALAAMVELLAGPLIGDLTSAESLAYDEGSRSSPYGGELLIAIDPRRMLGASAEEHLARAETLFEGIVEQGARLPSQRRFEARERSARDGVTIPEALHRELLALLE
The following text describes a protein:
Function:
Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (Probable). Acts as a regulator of the YscN/SctN ATPase activity (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSQTCQTGYAYMQPFVQIIPSNLSLACGLRILRAEDYQSSLTTEELISAAKQDAEKILADAQEVYEQQKQLGWQAGMDEARTLQATLIHETQLQCQQFYRHVEQQMSEVVLLAVRKILNDYDQVAMTLQVVREALALVSNQKQVVVRVNPDQAGAIREQIAKVHKDFPEISYLEVTADARLDQGGCILETEVGIIDASIDGQIEALSRAISTTLGQMKVTE
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MANLPCYPRPKSIYSSGVWLDESPVHSSLPLLLIQITFIVVFSRIIHSALRPLGQSTIVSQILTGFVLGPCFLGSFRFFKELYEPANIVNLKTVGTVGILYFQFLIGVKIDVGMLRKSGKNALAVSFGGHVIPVLAIALLRYLLSIGAITILMIRKSQIYNNAFQWSTSSIIVVASLLDEMNLLNSKIGRLAIAASLVETTVYTTVKAVAGLSFISRKVENYYTSVIVLSTNIAYILAVLYIARPITQWMVRKTPQGGQLSEEDFAFLIFMVLLFSIACIYIGIDISFSLFFLGLMLPSGPPVGSTLVDRLEGIVTNLYFPIYVAVIAIKFDFNLVMDYIKELKLAVFLDSITIIGKTIGVMAAAFFSARLSPRSIFALAFIMNTRGITELILVEKNYDWASIDPMFPTLSMVEVTAIAIIAAPLVKILYDPSKRYKGHTRRTMMQHYFNDNIELRVVSCIHRQENVPPTVNILESLCIDNENPFCIYLLHLRELVGRVTSVILPYKKIKSSPYGNPATDIVVNAFTAFEDRKNGNNYKGISNNNDDDNNIHIPGADCVTVQPYVNVAPYTSMYDDICDLAISKKASMVLVPFHRTIGFSGAIEEVSEDIRQVNLSVLKHSPCTVAILIDHGHNTDIDTALDNTIHNVVVYFLGGCDDRESLALAMRIGLNPRVGITVFHFKLKEDETKVDENEDILDNQMIEAFTVEFRNRNNMIYREEFVEDGEEMVDNIRMTSNAFDLIIVGRRQELSESPLTEGMSAWSEFSELGIIGDMLASKDLDCQISTLVIQQAKKPGNGKDGNVLKEF
The following text describes a protein:
Function:
Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Miscellaneous:
MISCELLANEOUS: Overproduction of this gene renders cells highly resistant to the alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine.
Sequence:
MTWHEVNDVIVITLPEIFDMNANLGYLTREKNECMYEIENNIITKVIAIGEIRSLVQVSVINNKQMIVQFLNDSRPVEQWKREEIVKYIHEWFDLDNDLTPFYEMAKADPLLKMPARKFYGLRVIGIPDLFEALCWGVLGQQINLAFAYSLKKQFVEAFGDSIEWNGKKYWVFPPYERIARLTPTDLADIKMTVKKSEYIIGIARLMASGELSREKLMKMNFKDAEKNLIKIRGIGPWTANYVLMRCLRFPTAFPIDDVGLIHSIKILRNMNRKPTKDEILEISVPWKEWQSYATFYLWRVLY
The following text describes a protein:
Function:
Global regulator with both positive and negative effects that mediates modulation of several genes involved in virulence. Negatively regulates the transcription of several known virulence factors such as lipase (geh), hemolysins (hla and hlb) and proteases (splA through splF, sspB and sspC). Positively regulates the expression of sarS and other genes including those encoding cell surface adhesins (clfB, sdrC and spa). Also, modulates the expression of genes not previously implicated in pathogenesis.
Miscellaneous:
MISCELLANEOUS: Virulence accessory gene regulator (Agr) and Rot have opposing effects on the expression of selected target genes and agr also controls negatively rot activity by an unknown mechanism.
Sequence:
MHKLAHTSFGIVGMFVNTCIVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV
The following text describes a protein:
Function:
Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.
Sequence:
MEETKSRFKRICVFCGSSSGKKASYQEAAVELGKELVERRIDLVYGGGSVGLMGLVSQAVHDGGRHVLGVIPRTLMPTVIIGETVGEVRAVSDMHQRKAEMARQADAFIALPGGYGTLEELLEVITWAQLGIHRKPVGLLNVDGYYNSLLSFIDKAVDEGFISPTARRIILSAPTAKQLVRQLEEYVPECDEIASKLVWDEVDKLNFVPGSRVAT
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MLERVAVLYNPLSDASIKLSRELADWLVERGVKTTRGVSQEFRDQPHLVADCDLMIALGGDGTVLRAARLCFPHNIPVLPVALGHLSFMAEIGPDEVYSGCEQIMNGGGWFDERSLVRAQLWRGGQKLSQHTALNEVVISRSDLSRIVNVHVTIDDSPLTTYHADGVIVATATGSTAYALAAGGPIVDPRSQALVLVPIAAHLTNIPSMVLHEDAVVTMQLRSRHHALLAVDGRENIDLIEGDEVVVRRSPQVCTFVRLRPSNQFYTQLVARLRRS
The following text describes a protein:
Function:
Required for normal development of intervertebral disks.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm.
Sequence:
MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSSSKEASSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKVTAGALRPSGPPKWERVMVDSISDTSRTSECRADTFTEENATPNKSLFRDSRNYSQKNVPKVSFSSSGLNSLEGEINKGPNVSGLQCAIPDLENQKLNFGKTKEIGQQGQENADKSHIPLPTRSAEFSIHDVKTQDQDVPVTGYGQVVLRSKVGRHANMNMNEDGESTPSSPSEEHTATDNIAFMITKTAVQVLSSGEVHDIVSQKGQDVQTVNIDGRKETASQHEGTEGEEPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMLTEEKIEEEEEDENEDSGVRTSSQMSCEQVDSRSDRMGQKAETQSQPHVLSAELLTPGVQGVRKAEQRKLSSADSPDSGNKCGMVDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEITRSQPEDALKTMARRQEQLSPEGTLPASRTDEIRKSTYRTLDSLEQTIKQLENTISEMSPRALVDTSCSSNRDCGASLPHMAQEVSPRSLLVLDEVPPAPEPPTSISPASRKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS
The following text describes a protein:
Function:
ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
Subcellular Localization:
Cell inner membrane. Note=Membrane association is not an intrinsic property but requires the XpsL/GspL gene product.
Sequence:
MEQRSAETRIVEALLERRRLKDTDLVRARQLQAESGMGLLALLGRLGLVSERDHAETCAEVLGLPLVDARQLGDTPPEMLPEVQGLSLRFLKQFHLCPVGERDGRLDLWIADPYDDYAIDAVRLATGLPLLLQVGLRSEIDDLIERWYGQGRSAMGTIVETADGDASSTDDIEALRDLASEAPVIRLVNLVIQHAVELRASDIHIEPFESRLKVRYRVDGVLVEGESPPAKLTAAVISRIKIMAKLNIAERRLPQDGRIMLRVQGKELDLRVSTVPTAHGESVVMRLLDRETVVFDFYKLGFTEDFLPQFRKVLEQPHGIMLVTGPTGSGKTTTLYTALSQLNTSDVKIITVEDPVEYQIEGINQIQAKPQIGLDFANALRSIVRQDPDIIMIGEMRDLETARIAIQSALTGHLVLSTLHTNNAAGGITRLLDMGVEDYLLTSTINGILAQRLVRKLDLANAERYAASPEEIERFDLRRLQPDGEIFLYRPRATAAAPTGYLGRTTIVEFLVMNDELRRAVMRRAGMGEIEQLARKSGMRTMYEDGLSKALRGETTIEEVLRVTEDA
The following text describes a protein:
Function:
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Sequence:
MGSRAICIQRVAPPCFEASQVKKIKTVGSFLVNTRSKRRRSTGVKCSSIADYIGGDLVKPDIGQWLQDVEEHKAIAIYAPHEGGYEGRYLNRLKMQGYYFLDISARGLGDPETTLLKNYPVCPAHLGKQPIARWYYPPEVDYRLAALPPSAKGLVVWVLEAKVLSKSELQFLALLPSLRPNVRVIAECGNWRKFVWKPLAEIANLAAQE
The following text describes a protein:
Function:
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis.
Sequence:
MGLSPAAVLIFLLLGVSQTYAAFSCKDQSGNDVDWFAVYKMPIEKDDGSVTGLAGGVAWYYVDVNKKGTLTPSAKTLDDNDQAIAYTLQQYYDKQNDKTIFHVMYNDEPWGSKSTSGIKLEEILSNRVYSNYTHEDDSTSTAFGHTKGTIFFDGTSGVWLVHSVPLFPNPTKYEYPVSGHDYGQTMLCMTFKYAQLKSIGTQLFFNRPNIYSSNLPTNMAADNADLAKAIAGQYQKGQPFQSVIELETMAGYSFTNFAKSKEFNADLYDTLVAPTLKTDLVVETWRRGSEIPLDCKLTYHANDALSIHVGSTTAFSYTKDHSKMAHSADMTKPWVCIGDINRMTSQYVRGGGTTCISSSFLWKAYSVIATQNNCA
The following text describes a protein:
Function:
G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.
Sequence:
MFPNSPDAFHQVRMMQSSIKASNFKLQSMEFRCHSNNVCEYQMEMLHHLLSVEAKTLPNLSLIEQQPEIKLGMRPLLLDFLMEVITILSLSRSTFPLTVNLIDRYCSTRIVKKQHYQLLGLTSLWISCKNLDSKFKVPTLNDLRKICVDSYYKELFVEMEKHILKSLEWVVNAPTFDAFIDLYSNLLISNSSNFEVANIIKKSSHKIKLFSNYIGELFQFYPNIYYDYTSSQIALIAILITVLTLKIPVDLISLLNFYNGLVKTEMFKSNVEQGAEDQFEEILSVDSFKSLFNKSFFKNLIKIIDNPPSSLKIKYFAENGKYSVLMKQLVTTASNTLKCILDPVPTTPKANSFVKHQQQQHHYHPRPPMSINTSMIPLTPVSNSTSPNRFSPDQIFSENESTPGIAFGTMTPDSQSTSPGEKRSYECIDELEIGTSTIAGYTLKNHDTLKRSKSANYGTLFYLQQ
The following text describes a protein:
Function:
Involved in osmoadaptation.
Sequence:
MPHLPELSKQEPSANTLVDNYRAKGEDLENSHHNNESRLAEGVHYDRNKAPALQEREKASTEKVNVEGGGASSSMVDNIRRGNPSGVA
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MLTERQLLIFRAIIDHFTWTIQPVGSKNLLKEKGLPYSSATIRNEMGVLEEYGFIEKTHSSSGRVPSEKGYRFYVDYLLQPKKLDKSDRQMIRSFFSENYYEMEGLIQNSALMLSDLTNYTSILLGPEATKNHLSGFRFVPINNFQAMLILITDQGHVDNHLVTIPEGTTLSDIERMVNILNERLVGLSLDDLKVQIPMEVKELLGKHVRNYESFMHVFSDSFAQASQQKVYFGGKTNILNQPEFHDINKVREMLHLMEEEQDVYELFRDIPDGLQVKIGRENNNSLMEDCSIITATYNIAGERVGGIVLLGPTRMEYSRMMGLVDVMSRDLTDVLTKLYRDNQN
The following text describes a protein:
Function:
May function as a co-chaperone.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGTTQTVSPVAGKDKTNDTSKGSPSKAKSNGHAQGKTKSKEMNALPPQKSVVIAYLCWLFGGIFGLHHLYLHRDRHAFIWWCTLGGYMGIGWMGELFLIPEYVRDANEDPKFVKMFVAKLQAYPKPPYSSKRFVGQVMIGHLFGQVCSMAIPETLVGGWDLSFLHWTIPLFVSLGVWLVGNIGREQGVWWHCLVAAYLAYPARYLIYDETYSLLLTGLVAALTFDGLSKQWRRTPPRRGSPGERTFKLTTAVIIYCAFWGSFLYFNGTISDEDGGEVPIHEAIHNFLASAWWTDLKQALLDTYNYAQHHGWYETWKEVFESMDVDGERNSYKVLGVSATASQAEITAAYRKLSKEYHPDKVKDEGLRAQAHQRFIEIQQAYSVLSKIKSNRRRKNKQYQEEEAIVL
The following text describes a protein:
Function:
Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
Subcellular Localization:
Cytoplasm.
Sequence:
MISTPYYLIDKSALLRNLQVIDQVRERSGAKVLLALKCFATWSVFDLMQQYMDGTTSSSLYEVKLGHQKFGGETHAYSVAFADHEIDEVVAHCDKIIFNSISQFQRFSSHAGNKPKGLRLNPGVSCASFDLADPARPFSRLGESDPARILSIIDQLDGVMIHNNCENRDFERFDALLTEVEQRYGEILHRLSWVSLGGGISFTTPGYSIDAFCERLRRFAQTYDVQVYLEPGEATVRDTTTLEVSVVDIGFNGKNLAVVDSSTEAHMLDLLIYRETAPIKNAQGDHAYQICGKTCLAGDIFGEARFEQPLQIGDRISIGDAGGYTMVKKNWFNGVHMPAIAIKEADGSVRAVREFSFDDYVSSLS
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
MKTHIMNKDLSMEVLRDGLTARDVLTNKVNSGGRDDKDDAFFVCDLGDVVNKYKKWVSCLPRVEPFYAVKCNDSPHVLQVLANLGTGFDCASKTEVQTVLNLGVAPDRIVYANPCKQTSHIRYAKKNSVDLMTFDNEDELHKIKNYFPDARLLLRILPPAAEAQCQLGMKFGCHPSQAPKLLEVAAQLDLSVVGVSFHVGSGCLEASAFARGVESAKRIFNIADQYGFDFDMLDIGGGFPGQESAAISFDEIVADLGPALDEHFPPASGVRIIAEPGRYFVASAFTVAVNIVAKRMVARDIQEFKDEEAEDAVMNSVAPSMCEEPAFMYYVNDGVYGSFNCLLYDHAAVTPSLMRDVDKEEALFSTSVWGPTCDGLDRIMEHCLLPELQVGDWILFEDMGAYTMAAASTFNGFSKPSCYYVVDANMWSSNNHAFIQSECYTRRQVKDSSITLPAIKRGLCAQERLGITQIPSVAVPEV
The following text describes a protein:
Function:
May mediate microtubule plus end-directed vesicle transport.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Endosome. Lysosome.
Sequence:
MAAAGESQLQRIIRDLYEAVEELSEEYKESEEPITDDSTNLHKFSYRLEYLLQFDLKVKTTFLGTKKDYWDYFNDCLAKVKGANDGIRFVRSISELKTSLGKGRAFIRYSLVHQRLADTLQQCLLNQRVTSDWYNAKSPFMKPDLSADIISHLYDLNQVLFDVAPRGHDLDASWPTFARRTLGSLNSPGHTWKPPSRSSSINSLASTYSQQASEFPSSLDHGQSLLNDLNESLPACMEDVGTVDSLRLELDQSELKQRELMEKVQQLGEEDAELRGVIEELQRQLDVSLSAQEEYQEKLKAMKEANEGLSREVQELKTQGKASEAQSVLLQEKLTAAEGKSVELMAKLDGILNDKGLQAAIHFDSAQKIHELLDRLKETEKGKMEAVSELDEKKMQGKKLEEDLRVKDELAKEAEAKLEAFAKENAQFEKKMEELCNHLEKLQRELTVKENEAGNMQRQLQDLQTSLEDREDKLEEVKKKAREEMEVAQKNFGEIAALREQLKKKDADLSSSSETLQHLQTSHLNLTADREKLIATLAEYKEKIQEETSNKEKFKMECDSLVESQERLLTKVSQSEELQKEMTANMRALQAELAALRASEKQLRGQLEDTKMTVDEKEQRLCEDNRALDESLQRAEMTAKLSDATVKRLEQENQSLREEKDAIQAALARLQADLQDVRKNSKELEETLGASQAKLQEQLQATQAQLESKEKDLVKMQSTLEELQRKEKELQIAKTSAEATCAKQTEMIERITSENRELEKSQLERDSAHAKDKQTVSGKLNVVERQLEVSMAEVSRLQAEVLELRVQVQRSEEEKLKFQAQLEVTEAQRDELRSLTEQLKSQTEAVNQQHVAELMELKKTEKELIEQRDREVAARAELTMSTAVLREQLSTLKAENHRLAVENSETRESLHRANTEMAELGMSVCKLNAEKEEVRGQWASKAAATEELEKEVEELRRCTEELQLENTTLIEELAKKEMLPGTVAELQERLEKTRNQVQNIKESSQEEVAAVRFQMSSENMSYQVQIKSVSEQLEKTKARLQEELSCGSSLRSKVSQLEGVNEEYLQLLGEKDAHITKTEASLRENVSEIVQLRRAVTSAEEAHFAARDMCEELKQRLKTAEAEKMSQHRKMTAEIDDLSRTKTILEERLIELIKDKDALWQKSDALEFEQRLRAEERWWLVDNEATHCLGCQGQFTWWLRRHHCRLCGRIFCYYCSNYYVTPKHSGKKERCCKDCYTQGGAVVEKSTEAEPSPSDEASSPPVAGHQPVPESAPCKPTPSVTAADSSDRSDDGLFDIITEEEVNGVYDSDAASQTTGGSEGETELRHQGAPGKDVTPDEEHAPTVQDSEINLLKSAEVTMTVPLNTEDISQFGDGSRELFIKSSCYSVITVAVSDCGSTISWMFSSEPKSICFSVVYRESCEAQVDQSKVLIPLTRCNSHKETVQGQLKVRHPGLYTLIFDNSFSRFVAKKIFYHLNMEKPVIYDGSDGP
The following text describes a protein:
Function:
Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAAVEPEVEDPLWSFVRVLEKRDGTVLRLQQYGSGGVGCVVWDAAIVLSKYLETPGFSGDGAHALSRRSVLELGSGTGAVGLMAATLGADVIVTDLEELQDLLKMNIDMNKHLVTGSVQAKVLKWGEDIEDLMSPDYILMADCIYYEESLEPLLKTLKDLSGSETCIICCYEQRTMGKNPEIEKKYFELLQLDFDFEEIPLDKHDEEYRSEDIHIVYIRKKKPKPPS
The following text describes a protein:
Function:
Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts. Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing. In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing. The interaction with nxf2 stabilizes the nuclear protein complex.
Miscellaneous:
MISCELLANEOUS: The name 'panoramix' derives from the mentor who empowers the French comic book character Asterix to perform his feats of strength.
Subcellular Localization:
Nucleus. Note=Nuclear localization depends on interaction with nxf2.
Domain:
N-terminal region is necessary and sufficient to enforce silencing of an artificial reporter gene.
Sequence:
MEAPMKLEVKVENYVECGINEDEATPLREGTGETPPHAFACGVPMSGSGWCSDPEDGNLVHHSATPTSDEHLQPSLDTIEPKMEPKIKEDADNAMLDSLLADPFENNSPATLQTPADVKPNAMLDSVEQGSRSCELLPSEFSKRENLDDMDLFSLKAAKTLVPDEQQSFPQNDTPIDDPEAADLIAQKREILKMLEMTAENRKVKHKKKKHKKERSHRSNKHQEESRKRNHSNSSSDEGADDKNQFDCDYRGHKKYKNRRGSASSQNESSKERKLRDTELDYVPVRPDEHFIRPIKFSNLIERRPPQVEFNTVNLSKADKRSLAVARAELVLEQIQQKANKEEPPEFHMVDTICKLPVNESFRNQDCFENPSPICNNMNVVYKFNSTPGTRIDLSKWGLETVPEATKRLLRLLGIDVARLKELQSTVKPSQRILKLKKEQLEQGLAPTEEQETATLYKNAATQTERRTATRDAGTQVRLESKLNGAFWQNPHFDPMNLTQHQSNVMLALQEIYQTLPSATMAVKLSRALAPALAIIKGRQP
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRLPRLQLHAATVASQSTPMSSALVVMDDITMNDPGHDRAGVIWDFDPNMTHEIYEDLGVMDLDTVDSKQCTQKQKNKSLQSQKTDPVVIKPVIEHTTPSPNAVRASAQNHLHNGQNCSCVRRIFKNKGQSGTDPFLFLSDEVILSVFRWLPKKSLTHSAKVCRRWRRLSYDEELWKRVDLSSRNFLPGVLGLILERGIIHAKLSRCTINGPVFDADLDDSAMEEDEPGDLDSSRLHPAPSNSLQLQSLDLSACINDDPANIQAILAQCHSLTRLSLESCQLDGDTLLTLAEHSTALEVLDLAMCHLTKPEALTTLIRSAPGLQSLNISWLNLSAENLKEVISVLPTQLKHLNLGGYREKLQNQDVVTLVSRCHDLKQLDLSDSTSLTYEAISAVVQNLPCLEHISLSRCYDIPFYAFVSLIDISFLKGLDVFGVMQPREQERLKVQMPKISFNSYPFSAIARPTFSAKQPHHIWGVKCEVI
The following text describes a protein:
Function:
Acts as a magnesium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDEHMDGAPSAAASVLDHVPMRNEDGEIRHEFVEEIARAIEAGDSAALRACVAELHEADLGDLIGALEPDDRVRLVELTGRDFDFSALNEVDESVREEILDELPPETVAEGVRELESDDAVELLETLDEAEQEEILEKLPMRERVALERSLLYPENSAGRRMQTEFIAVPQDFTVGQAIDYMRETPDLPDRFYEIYVVDKDQHWQGAISLDVLLRARRPVALAELTDEDRRRVSVLEDQEEVARMFGKYNLVAAPVLDTQDRLVGVITVDDVVDVIEEEADEDLKALGGVTSDEELSDTVFTIARARFNWLLVNLATAFLASSVLGLFEGQLEKMVALAVLAPIVASQGGNAATQTMTVAVRALATRELGSSNAWRVVMREGLVGLVNGLAFAVITGIAAVAWFKIPGLGIVIGLAIICNLVAGALGGILIPMALERVRADPAVASGTFVTTVTDVVGFFSFLGIATLWFGLR
The following text describes a protein:
Function:
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSXDEYALNKQELKALIKELKKWKAPATVLLSLYIPPGRPIPDVVNLLRQEYSIAQNIKLKRTRDAVLSAIGAAIDRLNKIPKIDGNGLVLFCGENFDTEDFKCFMFSPPDKVPLFFYRTDKEFHLEFLEDMVEDTAVYGLIIVERDEATIGLLKGARIEILEEIEGFVPGKHMMGGQSQRRIDRIIDEMYHNFLKEVGEKVNAYFMPFVQNGKMKGVLLGGPGYAKEDFYKEDYVDYRIKNLILQPLIDVSDQGEVGLREMIMKAEDLLKNQQYIEVEKLLEELKYHLAKDDGLIIYGKEQIKKAMEIGAIEAIVIHEDSTDKELEKLAQDAENYGVKVFVVGDEVPEAEWVKKTFNGIVGKLRYRLY
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MFNNSLMSSSTSSPSQASQENSESVPPSFLFANQNKRRSVALSNANPYLNSPLSYSGGPSTDIFASPTPIPAHVKESASSSGKSVHWSPNIVDDATHRSISRLGSSSVTKGPPLRSLREDMDSPVTKLPRVLPSSAPSSLANKDSPAGADHWVTVFGFPPNFTDKVIKLMSRHGEIVSQQVPSRGNWINLRYSCTVHAEQAMGRNAFLIDGVVRIGVVPCTDTEAIESANRSVLNLSHFEEPMEDDSRRTLPPPIAPTNETSFNNSMLNTSVRENSVSRAGSFRSSSRAGMRSLAATTRHNDSLKGSEPTKEGGLIGRLWSLVG