lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types.
Subcellular Localization:
Nucleus.
Sequence:
MEDTAASVTLGSEKRSCPDEEQHSAKRIRVEEEPQEDEEEEPQEEEEPEEEEESFADMMKHGLTEADVGIHRFISEHTGFSGILKERYSDFVVHEINKEGRMVRLDDLCVPAEEQDRLDPSESSSAEAQTLSEEQKQQLEDLQLFRNKEGQVFIQVQEDSKEQRTLLHRAVKTLFPGLETKTEERDGQRVIVAYHAAGKTALAELRPSAAPRKHSWPKNRGSFCHFVLYKENKDTMEAINILSRFLRVRPNMFSYMGTKDKRAISVQEIAVLKISAERLSHLNKCLMNLKLGNFCYKKHPLKLGELQGNHFTVVLRNISGSQQQVDQAMNSLQNTGFINYYGMQRFGTTAVPTHRVGRAILQNNWKEVVDLILKPRPGAEKGYLVKCREEWARTQDPAAALRKLPVKRCVEGQLLRGLAKHGKHNIITAFALIPRNNRLMYIHSYQSYVWNSMVSRRVDAYGLRAVEGDLILRGGSAHVLSADEAQKHSIHDVVMPLPGFDVIYPTHSVGQGYREMLSADDLDIDNMRHKVRDYSLAGAYRRVLIRPSDVSWELVQYDDPRVPLVHTDLEKLENKPAPVYLTEGKYCALKMEFSLPSSTYATMAVREVLKMDTSIKNQTQLNTSWLN
The following text describes a protein:
Function:
Regulates the blue-light dependent dimerization of CRY2 and formation of photobodies. Inhibits CRY phosphorylation.
Subcellular Localization:
Nucleus.
Sequence:
MKNTNLPEETKEPISPGSSHRKQNKTGTKTCFPETTVLSGRDRLKRHREEVAGKVPIPDSWGKEGLLMGWMDFSTFDAAFTSSQIVSARAALMADSGDDAGARGSRPQRLRVESSC
The following text describes a protein:
Function:
Has both aldehyde and alcohol dehydrogenase activities. Can use acetaldehyde, butyraldehyde, butanol and ethanol.
Sequence:
MKVTTVKELDEKLKVIKEAQKKFSCYSQEMVDEIFRNAAMAAIDARIELAKAAVLETGMGLVEDKVIKNHFAGEYIYNKYKDEKTCGIIERNEPYGITKIAEPIGVVAAIIPVTNPTSTTIFKSLISLKTRNGIFFSPHPRAKKSTILAAKTILDAAVKSGAPENIIGWIDEPSIELTQYLMQKADITLATGGPSLVKSAYSSGKPAIGVGPGNTPVIIDESAHIKMAVSSIILSKTYDNGVICASEQSVIVLKSIYNKVKDEFQERGAYIIKKNELDKVREVIFKDGSVNPKIVGQSAYTIAAMAGIKVPKTTRILIGEVTSLGEEEPFAHEKLSPVLAMYEADNFDDALKKAVTLINLGGLGHTSGIYADEIKARDKIDRFSSAMKTVRTFVNIPTSQGASGDLYNFRIPPSFTLGCGFWGGNSVSENVGPKHLLNIKTVAERRENMLWFRVPHKVYFKFGCLQFALKDLKDLKKKRAFIVTDSDPYNLNYVDSIIKILEHLDIDFKVFNKVGREADLKTIKKATEEMSSFMPDTIIALGGTPEMSSAKLMWVLYEHPEVKFEDLAIKFMDIRKRIYTFPKLGKKAMLVAITTSAGSGSEVTPFALVTDNNTGNKYMLADYEMTPNMAIVDAELMMKMPKGLTAYSGIDALVNSIEAYTSVYASEYTNGLALEAIRLIFKYLPEAYKNGRTNEKAREKMAHASTMAGMASANAFLGLCHSMAIKLSSEHNIPSGIANALLIEEVIKFNAVDNPVKQAPCPQYKYPNTIFRYARIADYIKLGGNTDEEKVDLLINKIHELKKALNIPTSIKDAGVLEENFYSSLDRISELALDDQCTGANPRFPLTSEIKEMYINCFKKQP
The following text describes a protein:
Function:
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MSENLIIFNARIVTPTGTSARKGAEMGQLRIIENGTVEVTKGIITYVGESRGEDRDGYYQHYWHYNARGHCLLPGFVDSHTHFVFGGERSEEFSWRLKGESYMSIMERGGGIASTVKATRQMNFLKLRSAAEGFLKKMSAMGVTTVEGKSGYGLDRETELLQLKIMRSLNNDEHKRIDIVSTFLGAHALPEEYKGRGDEYIDFLIREMLPVIRENELAECCDVFCEQGVFSVEQSRRLLQAAKEQGFLLKLHADEIVSFGGAELAAELGALSADHLLQASDAGIRAMADAGVVATLLPLTAFALKEPYARGREMIDAGCAVALATDLNPGSCFSGSIPLTIALACIYMKLSIEETITALTLNGAAALHRADRIGSIEVGKQGDFVILNSDNYHILPYYVGMNCVIMTIKGGMLYPVN
The following text describes a protein:
Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MAILKFVPFSTNIHPTFWQELSSLKIDKLQLSDDAVAIHAHYTAGKVVLDRQTGESVSLGSQISLDAASLQSDMSHDSISFRSTSCSAVTSLSAVQQSCPGIAARGFLQNFNTIESFRNADKQFIFDNTVRGIWKGLTDEQQDPEVFLTTFLALTFADLKKFKFYYWFAYPALTTNPPWEVIDDAEGVDKVWKPISTQLNEVDYSVIASWVQQQSVRRGFFLFKAAVGKVGQCGRISTYASFFDGVAESERYVGFVDPSGTSQTPGWPLRNLLAYLHARFGVEEAQVICWKDEIANAASGLTFGQTRSVFGKVRLPVSNTTDGVSTMGLELDGRRTRLTCKQNNVQLPNGVGWERNAQGKLAPKVADLGPLMDPRKLADQAVDLNLKLMRWRIMPEIKLETIQNTRCLLLGAGTLGCYVARSLLGWGIRQITLVDSAKVSFSNPVRQPLFDFEDCLEGGQPKAECAARRLKRIYPGIDAQGISLSIPMPGHPVAPIAEPQVREDVGRLEKLVDEHDVIYLLMDSRESRWLPTLLGAAKSKLVINAALGFDSYLVMRHGAPPQSAESVTGVAPDASKASKGKDAKQSWHGRLGCYFCNDVVAPSDSLTDRTLDQMCTVTRPGLAAIAGASAVELMVSVLQHELGLHAPATAGESLRQGIEDAQAIADATTVLGIVPHQLRGFLAQFNTLRVVGQAYDRCTGCSAAVVDAYRTEGFEMILRAMNEDKYLEHLTGLDKMYQEADEMEAAVDWDVQDDEDEGF
The following text describes a protein:
Function:
Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
Subcellular Localization:
Host cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.
Sequence:
MNIFEMLRIDERLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSIWYNQTPNRAKRVITTFRTGTWDAYKNL
The following text describes a protein:
Function:
May be involved in vascular wall and kidney homeostasis.
Subcellular Localization:
Secreted.
Sequence:
MVIHIEKALFSLLFILSYLYGGLAIGMGTQDGSEKWGYIPVRPKAQMFWWYYRSPFRTQDPNNLWPIILWLQGGPGSSGVGFGNFKEIGPLDTFLNPRNSTWLKKADLLFVDNPVGVGYSFVEDETLYVRNDEEAARDLTTLLIAIFNEDESLQKSPLYIMGESYGGKYGVTLALYALKAIQAKQLNLILGGIVLGDTWISPEDYVASWGPLLKDISRLDNNGLKKYNSLVDEIKEQVAYGRFEDAIHILNSLETGLQTDTNNVNFYNFLLDDDSASSTTTTQSQEAPSGDLESLMNGAIRSKLQIIPDNVKWKMQSPPVFKNMRGDFMRPRINEVDELLKKGVDVTIYNGQLDVICATKGTEAWVEKLKWEGLEAFLSIDRTPIYCGDEKVTKGFTKSYKNLHFYWILGAGHMVPEDQPCVAFNMVGNITNSSGPATF
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTINYNLAVSTSKPWTLFKLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFERIVQYCDSRLSYIPLNFMLGFFVTAVVNRWTYLYQIIGFIDNIGLMAAEYVRGRTEQARMYRRNIVRYCELAQVLVFRDISMRTRRRFPTLDTVVAAGFMMPHEKDRFDEIQYKYSKYWVPFQWAFSLTYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQYVVSEHADNKTEIDLYFPIMSTLQFIFYMGWMKVAEAMLNPFGEDDDDFECNALIDRNITMVLMMVDQGYDRAPDLKRDDFWDEEVEPLYSEETAKIPNNPLKGSVSDVKLPEYVHEIKMVPHCDDASPLVPGDEMRRRRVSVVPVKPSDQQHHHHGHRTRTSLGNIEMFRSFKNKIERSFSKPHLHDDLGRKTFSHGMLENMEFEGSNTNIADGSHANNNSFTNSAFVNSGEDLSNKRIDTSSSQPQLATGKRGSEHPFQHHVLDDVLEDDESDENQLTIRKKSSVLQPAITLVERFNEATGQLETEVKRDEKKKKEEELREEGDNGKEEKDNKEDKKEEQDRPSRPTRPFFIGVVRSESEDHSHPHLRPPTKFE
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
Sequence:
MKRKKTVLQQILSEKRKKVKEGDSMSGKDEFGTTKYVIYAEFEANGVVERPDVVGAIFGQTEGLLGDDLDLRELQKTGRIGRIRVEVHNKAGKTYGTITVPSSLDRVETAVLAAALETIDRVGPAEARIKVLRIEDVRATKRKYIIERAKEILETLMEQEIPETQEITEEVKKAVRAKELIEYGPEKLPAGPHVPFSDSIIVVEGRADVLNLLKHGIKNAIAVEGTSIPETIIKLSKERIVTAFTDGDRGGELILKELLQVADVDYVARAPEGKEVEELTKKEIVKALRSKVPAEQVINEMFNKGRSFYELIRERESEGERQPRQVTKPEPEVVKAQPKAETPEEKREPATVVRPSAEKIVKPIETSKSAPELEEFREFIERVKKDGIALLLDENKNVIAEIPVRELTNQLKERKDVYAVVFNGVITQRLIDTVSESGVKYIVGARKYNVVRRPVSLKIITFAE
The following text describes a protein:
Function:
Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement.
Subcellular Localization:
Secreted.
Sequence:
MLLICISVLAAISAHPLSSGEMRAAVSNLVREIDSTHLTTKPSLKIIEGLEDNTVSTGESVTLRCDVLSTPTGVIYWEKDGQRIQGDKELNVFEKVLNAMGPTVESGIITSSYQIPCANLHHIGSYKCVATNGHDTVESSAKISVEGQTVKCKSTRRSAPVITMSTESRFELQDNAATLICRADRRANWNWMFEDKKIDFDSGRYELLPSGDLLIRKIQWSDMGSYFCIAHNKYGESRGETFLYPTKKHIA
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MEEELICRGFDSVEVLFVDVFEKSRLSVGGDGERMLQTPQTGSLMLSSLLTTRRTISSMAALQQPSRHRFPPPNNIQRLPLRPDGQQEPIKLTEAIKQQFKQSIPLLAARVPSPSITKFKTNPEIRKALLNSKNLRSVEPDPDSTDNAFKLLLLNTPHKDQIPESTLKVFQEHDIQIKNTKLDLDWEYWMADEIIERLLPDQLTDIPASFTMIGHIAHFNLRDEYLPYKYLIGQVILEKNLAIKTVVNKIDNINSQFRFFEMELLAGEPDYTVTLWQSGCRYRFDFSKVYYNPRLSTEHDLLSSMIEKDEVVVDAFAGVGPFAMRAAANRKAWVLASDLNPASVEALETNVRLNKLQGRVAVSGGDGREKIREAVRTLWLDKPFKTPNSSPLLPDHFIINLPDSSIQFLDAFRDLYHPLSDSEGFLNAVKKKSRLPLLHCYCFTKQVDEPESDICQRVSEVMKVEISPSTVARFELKFVRAVAPHKDMYRITFELPLKLLFSSSSEESRA
The following text describes a protein:
Function:
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity).
Miscellaneous:
MISCELLANEOUS: It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report. These results are now controversial and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
Sequence:
MDNYTVAPDDEYDVLILDDYLDNSGPDQVPAPEFLSPQQVLQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAPLWKYVLTSKMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRKAFMRYLRSLFPRCNDIPYQSSGGYQQAPPREGHGRPIELYSNLHQRQDII
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRFFHAKEDSDSDTSSSEDEVEDQKVNKSAKFRDDLDFMAGPEEDEKRVVRAQKDKKFDELKGIIKQNRDAKSNKDLNRLLTGFDSLAKAYDKSKTVFQRQNVANPRFYIRSLVEIEDYVNKLWDDKDAKSALSKNNAKALPPLRQKLKKYIKDQQLQDLVTDYRVNPDEDGYETPEDEDDDDFGEVSESKAEKSPGKPSEKAAVSDSDSDSDDDDSSNWSSEPESNSSDDEDSVTKMEQLRRYFLKKEFRVESKDDKKEKKKRVIRVKEAVEEDDDADWTPVNREKSVVHFDPKEEVTHDVMIKKLNEVMSARGKRTTDRNQHVANLRKLLEVSEEKELGLGINVKISFCIISALFELNAKISDHMEYETFMTTLQTVNSLLDLLIGTDRVKLSVTYAEEDENLKDDTQEYRIQGSILIAVQRLDGELAKILQNADCHSNDYIEKLKAEKDMCSLIEKAEKYVELRNDSGIFDKHEVCKVYMMRIEHAYYKYQDQNEEDAGKLMDYLCNKIYTLDDEKRLRQRAMLCHVYYLAVHDKWHRARDLLLMSHMQAIVDHSDVDTQILYNRTICQLGLCAFRHGFIREAHQGLSEIQNTQRAKELLAQAVGTRQHEKTAEQEKIDRSRQVPYHMHINVELMECVYLICSMLLEIPHMASCEFEMRRRMLSRSFHYQLKQSEKASLTGPPENTREHVVAASKAMLNGDWKKCQDYIVNDKMNQKVWNLFHNAETVKGMVVRRIQEESLRTYLLTYSTVYATVSLKKLADLFELSKKDVHSIISKMIIQEELSATLDEPTDCLIMHRVEPSRLQMLALNLSDKLQTLAENNEQILEPRTGRGGYQGPGSWFPGRNERQGDKQKGSGGYQGERRGGQGQDGKRGNWGSQGGQQRRHPQKPRAF
The following text describes a protein:
Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Domain:
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Sequence:
MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPYPVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPPHRTASVFGTHQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGLPVCLSRAPQPTSPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
The following text describes a protein:
Function:
Reductase that catalyzes the conversion of GDP-6-deoxy-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (GDP-D-rhamnose).
Sequence:
MRALITGVAGFVGKYLANHLTEQNVEVFGTSRNNEAKLPNVEMISLDIMDSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCRILTIGSSEEYGMILPEESPVSEENQLRPMSPYGVSKASVGMLARQYVKAYGMDIIHTRTFNHIGPGQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAYWLLSQYGKTGDVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNPLQLRPSEVPTLIGSNKRLKDSTGWKPRIPLEKSLFEILQSYRQA
The following text describes a protein:
Function:
Probable transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTQESSSSNHYVDESSFDNNNNNNNNGGEGSSNEILIRIPFLHDSVPALYAMFALASLFVLLATILSAHLIYKHLKYYTQPDHQRYIVRIVFMIPIYAIYSLLSLLLHNYQVYFALLRDCYEAYVLYMFFALCVSYGGGDKNLVTHFTSHPVMRLPMPLFFKFKPNEAFLQVCRMGMLQYVLVRPAVTLASAIFEIFGLYDEGSYAINRFYFYNAFIINVSVTVALYIVVLFYQAAAEELAPYKPLLKFTSIKIVVFFCFWQSIAISGMTNFGWIPTLDGWNSGEVSTGLQNFLICFEMFGVAILHQYAFPYELYRVRAFSAAPLIHRVEMGTVFKSVINSVSQKDMVKETVKSFKGTKITDGKTGLYSGLKDEVFNEFDIEEIEMGDFTSANDNNNFDDFDFSENNINSNNKDNNSSIYNDGASKKNHIGSAILAGGGGGGKKDNDLITDDDFFSLMNNDYANIDFSNFDQDALEEMNFDDDDDDMAFTARR
The following text describes a protein:
Function:
Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.
Subcellular Localization:
Secreted.
Sequence:
MWYLAFLLIIGAYAADHAWETGNEYHYLIESRTLTVLDKLSQQFSGIVIKGGLTIQVKSPDTLQAVVSKTQYAPVHKTLENWNDEIADLKFDELSMSGKSFEIKLKHGVIRDVLIDQDVLTWEVNLIKSIVSQLQVDLQGENVIASSDNQIPDDSQPFGVYKAMEDSVGGKCEVLYSITPVPENFDSIPFPNLRKDGLNFFVTKTKNYNKCEQQMAYHSGITDKMNWKLGSNDGVLSRSSTSSIIISGNVKHFTIQSSLTTSEIFVRSKLHDTYSSAVYDSVKLTLDRMNQISNPMSASNNLVSTGNLVYIYNNPFSNQRKLRQPSVSLNSMEARSSENSNEENRSDDDRSNFLSNSGEEREYLQSKPTLNEAPESPLLPYFIGYKGESIQKSEDITSVAARFIAQIAWNLETSPVNAFNFSPSTEYIEPCIILIRLIRTMNVEQIAELENKLSDPIYHLQGNKLPTEYKKSYDKTTWDIFFNAVVSAGTGPALISIKNMIKNGQLKDTQAAMIISKIPKTALTPTSEYVNKFFELITDEQVTKQRFLNTSALLAFAELVRYTQSNRSIHYPVHSFGHMVSKQDNALLETYIPYMANQLTEAIKDGDSRRIQTYIMALGNFGHPKVLSVFEPYLEGTLPASTFQRLMMVVSLNRLSENFPRLARSVAFKIYMNIMEAYELRCAAVYVVMKTNPPLVMLQRMAEFTNQDQDRHVNSVIKTNIDALANLEQPEFQDLAAKARIARELLNPHIDTESYSQGFLFKKIIPSLNMAEITILQIIGSQDTTVPKSSYLNIYQSYGGFNLPPSRMSYEISSFRALLDMWYEMPWMIENETQKKLIIEETIEKLGIKGEDPVQFEGNIFVNTLYSSQFSPLDNNTIEETINAFKRIISSWQRSSKNFTSENINYLHYYDMTVAFPTESGLPFIYTLTVPKLLRINIGGGHKGSKTEHFKELTAAGYIMVHEKVQSRIGFVTPFEHRHYVAGIDTNTRLVTPLGLSISVNTTEENKKFKLTLQPSKYIRYGTGHSTVHFSVVPYTARNNILDLEHDFSKQDNDTLPVHTKEPHEIHFYISNWMFVAKSDLIDSKASEKQGMEAIKETVNLFCNSRGAYYRRFDGLMYFGEVRIRASYDFAKLDSDSSEATIPTIVNKEPDSEERKKQFLKEVGKNMNSAYGYVFDMSIDQGFDVQVFTLAYSYSQIDHKSQALFYWNVQSVDDPKIYAELGAIGYVKSKSISLNPEKALEQIPNDEFKAEIRLGNNFNEEMIKLEGNWTRTDDVKDMAMKSEIVKKCRQDMKQGNILLPACQKANKLINQKDLLMMSIDTTSDILYASANRGILWIQSLISENYVETMNLRSSSKNTIDMEIKMLPDNDDAKISLRTSQADVSFSLKDIIGNDSNVSMKDTFKEQLDDESVCVLDKTHAVTFDGKVYPLKLGKCWHVMMTIYPKRDPNNFEKTLSIPSDMRAIVMAQEMDDGSKQIKMILGDQEVHLQKSGDCLEASVDGETANFSDHKSHQEKDFEIYGSNETITVFSPTYEITVEYDGEHILLMISDNYLNAVRGLCGNYDTQPNNDFIIPENCILTKAEEFAATYAMTQESCQGPAPENKRKAEQSTCMSRSYRPSDVISDREAGRSSTKNRGWGYH
The following text describes a protein:
Function:
Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MDTGEFISTVENMDPSLTELGDEFTLGDIDEMLQFVSNQVGDFPDLFEDHMTQAGSLQSSGAGSAPQAAAQTHQTPPAAVYQSPNPSLASSQSLSPQCVPPTPPLTPAQSPPTIPAATVQQHQVTRSPPLLQPRPPAVQPIQPQPQPTAQPTIQVHTQGVPVQTHSFPVHTLVQTHSQTPLPIQTQAPQTVMIASNAGQSRFIQNSVICHQSPGHSFQVLQPQMQSIMTSPQLQPVTIQHQRVLTPTGQTIQTLSTAPTTVHTMQQQVQQVQQVPVLVQQPQILKTDSLVLTTLKPDGTQVLSTMQNPAGITTLTTPIQNTALQVPTLMGSNILTTVPVMMGGGDKLPIKQLQAASPNAPAGVRPSMEQNQGMVGGMGPGVVVKEGERRTTHNIIEKRYRSSINDKIVELRDLVMGSDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLALKVANQKNKPVTLPEDVEMKQEVVMMSPPASDSGSGSPHQYSPYCVDSEPGSPLLDHDQVKSEPDSPSSVGVMDRSRLLLCALTFFCLSLNPLPSLLGSESSGTSGPPAGHGPSRTLVWFPAHTQDFASWLRCLVPWVIVWVLSGVGAVWGCVRVLYLWEPVTPLHSPNSVSFWRHRKQADVHLHRGDFSAAMASLETCLSVLTRALPSCGLDLLCSLSWNLIRYLLHRPTPLGWLVHQIGGKHEGEESRTSAKDAALVYHRLSQLQLTGKLPQRSSLWALSVSLSAVNLSESAQGKMAPAQLAQIYVTAAIALRTVLGHHLSCLPGYLLSCAESVANQSDTKPVPDCLRWLFTPLGRQFFLSCEWSVKSETSDSVYASQRDPVDPIAQLHRCFCRKLLERAVHTLIQPQSDSDTNCRNSDFGEFSSALEFLELLNSCTEDSSSAPPPFSSSPNQTAMPVGDPVCRWWALVLKAAVHWLQGDDVAVKSLLTEAERMPRALHVLDHPLPKAVLLLCKVVQMSLCSLKGEGLIACLAHCDRASGYLRSSVSVPLGLSGSWLNKGVELLVCDLLLTLRTSLWQRAGSSNGEPGPAPGTQLSGFQRDLSALRKLTQCYRQAQHKLFLHETTVRLMAGASPTRTHQLLEHNLRRRTHSSYSAEGECILGERERAHAILLACRHLPMPLLTPPGHRARLLAEAKRTLERVGDRRSLQDCQQILLRLSGGTTIAAS
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATRSALIQQRACGSLGALEATWWKNEQLVEKPFKLGLMRGSSLQCRPRPAMKALISSSGEVRAVKEGTLAEPPVEELQNGAHSVPAALRVASTPSNEHIGYGFVDEKNFYRERFVVRFSEVGSRGTMSLEMLASLLQEAACNHVVKIGYGAFAGRSDRLITVTTRMHIEVDRYPAWQDLLEIDTWYCTERRNSVRRDWTVKDVKSGEIIAFATSTWVIMNMDTKAIQRITDAIRDEFAPWARDPPKWALSEDRIKTSSERIPKINGDAEFYKTGLYPTERDLDMNQHVNNVKYISWTIESLPLEFRETHMIHKIALEYRREVQKNDTLESRAKKELLNDGALLAGDTHEEHYIHVIRNQDGQEINKGRTIWTPVQK
The following text describes a protein:
Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, cytosol. Cell membrane. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.
Sequence:
VLLLSQDYGKYKEVAELTRTQILAASYELHK
The following text describes a protein:
Function:
In neurons, involved in the transport of late endosomes/lysosomes. May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking. May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress. Required for proper lysosomal acidification (By similarity); (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors.
Subcellular Localization:
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Note=Colocalizes with LAMP1. A small fraction resides on the cell surface.
Sequence:
MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPSISHKPITAKLVAAPDATKLELSSYLYQQLFSDKPAEPYVAFEAPGIKWALYPASEDRSLPQYTCKADIRHVAGSLKKFMPVVLKRVNPVTIEHAIVTVPASQYETLNTPEQVLKALEPQLDKDRPVIRQGDVLLNGCRVRLCEPVNQGKVVKGTTKLTVAKEQETIQPADEAADVAFDIAEFLDFDTSVAKTRESTNLQVAPLEGAIPTPLSDRFDDCESRGFVKSETMSKLGVFSGDIVSIKTKNGAERVLRLFAYPEPNTVKYDVVYVSPILYHNIGDKEIEVTPNGETHKSVGEALDSVLEAAEEVKLARVLGPTTTDRTFQTAYHAGLQAYFKPVKRAVRVGDLIPIPFDSILARTIGEDPEMSHIPLEALAVKPDSVAWFQVTSLNGSEDPASKQYLVDSSQTKLIEGGTTSSAVIPTSVPWREYLGLDTLPKFGSEFAYADKIRNLVQISTSALSHAKLNTSVLLHSAKRGVGKSTVLRSVAAQCGISVFEISCFGLIGDNEAQTLGTLRAKLDRAYGCSPCVVVLQHLESIAKKSDQDGKDEGIVSKLVDVLADYSGHGVLLAATSNDPDKISEAIRSRFQFEIEIGVPSEPQRRQIFSHLTKSGPGGDSIRNAPISLRSDVSVENLALQSAGLTPPDLTAIVQTTRLRAIDRLNKLTKDSDTTLDDLLTLSHGTLQLTPSDFDDAIADARQKYSDSIGAPRIPNVGWDDVGGMEGVKKDILDTIETPLKYPHWFSDGVKKRSGILFYGPPGTGKTLLAKAIATTFSLNFFSVKGPELLNMYIGESEANVRRVFQKARDAKPCVVFFDELDSVAPQRGNQGDSGGVMDRIVSQLLAELDGMSTAGGEGVFVVGATNRPDLLDEALLRPGRFDKMLYLGISDTHEKQQTIMEALTRKFRLAADVSLEAISKRCPFTFTGADFYALCSDAMLNAMTRTANEVDAKIKLLNKNREEAGEEPVSIRWWFDHEATKSDIEVEVAQQDFEKAKDELSPSVSAEELQHYLKLRQQFEGGKK
The following text describes a protein:
Function:
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Sequence:
MGEKVKLEEISAADFFYRNRSLAGFDNPVRATYTIIRELVENSLDAVELAGRSPKVLIVMREEREGGEESLPWYRIRVADNGIGMDPEEIPLAFGRVFVSSKYRLIQSRGTFGLGGTMALLYGQITTNMPFKITSAREGEPAYELTMMIDIRKNEPIILDRKIKGVSRRSFTIVESTFEGNYPRAKRKIIDYLQQTAIVVPYISIAFMDPEGHLYIFPRSTEKIPPRPKEALFHPKGVDLELLQRLLSSTRTRSLESFLMTHFQRVGKKTASEVLKIAGLPPDKRPSDLKDEDIRRLYEALRSYKEFLPPDPSVLSPLGEELFESGIKKELQPEFVKAIQRPPSVYEAHPFIVEVAIAYGGLIKPTGDIQLYRYANKIPLLYDASSDVSYQVIKKIDWSIYGIKNPEDEPIAFFIHIVSTKVPFKTVGKEFIANVPEVAREIELGLRGCARELRIYLGRKRRKEMLLKRYELFRMYYELISWTLEEIIGERPPIENLIEKIKGSAGDEDERE