lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAATVPAPATAATVQTAVIPPPTVAVATGGGFLSSSLYVGDLDQSVNEGQLLELFGQVAQVVSIRVCRDQTRRQSLGYAYVNFSSHQDAVNAMEHLNFTPVNGKPIRIMISNRDPSIRKSGYANVFIKNLDLSIDNKALRDTFAAFGTVLSCKVAVDSNGQSKGYGFVQFESEESAEISIEKLNGMLLNDKQVYVGHFIRHQERIRANGSQFTNVYVKNLPETTTDDDLKNLFAPHGTITSAIVMTDSNGKSKCFGFVNFQNTDSAAAAVEKLDGTVLGDDKTLYVGRAQRKAEREAELKAKFEQERKSRFEKLQGANLYIKNLDDHIDDEKLKELFSEYGTITSCKLNEMNGKMKGRKPLYVAVAQRKEERKARLQAQFAQIRAAGGISSLPSGIPGFHPGAARVSPQQMYYGQGNPGLAPPQPAGYGFQPQLMSGMRPGMGPNFLMPYQFQRQGQPGPRLGVRRGGNSQPLPQQQLPLRGYGQSFRYMNNARNGLETPVLPQGLVSPMMPLAFDGSGVSSPPNDIQRSRAVPTSTLASALASASLENQRVMLGEQLYPLVERLEPSHAAKVTGMLLEMDQPEVLHLIESPDDLKSKVAEAMEVLRKASSEPELSDQLGALTLTK
The following text describes a protein:
Function:
Involved in rRNA-processing at A0, A1 and A2 sites through its action in U18 and U24 snoRNA 3'-end final trimming. Negative regulator of telomerase through competition for binding to EST2 with TLC1.
Miscellaneous:
MISCELLANEOUS: Present with 3850 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGLAATRTKQRFGLDPRNTAWSNDTSRFGHQFLEKFGWKPGMGLGLSPMNSNTSHIKVSIKDDNVGLGAKLKRKDKKDEFDNGECAGLDVFQRILGRLNGKESKISEELDTQRKQKIIDGKWGIHFVKGEVLASTWDPKTHKLRNYSNAKKRKREGDDSEDEDDDDKEDKDSDKKKHKKHKKHKKDKKKDKKDKKEHKKHKKEEKRLKKEKRAEKTKETKKTSKLKSSESASNIPDAVNTRLSVRSKWIKQKRAALMDSKALNEIFMITND
The following text describes a protein:
Function:
Filament-forming cytoskeletal GTPase.
Sequence:
MAERTMHMPTQISADGDTQKENNIRCLTTIGHFGFECLPNQLVNRSIRQGFTFNILCVGETGIGKSTLIDTLFNTNLKDNKSSHFYSNVGLQIQTYELQESNVQLKLTVVETVGYGDQIDKEASYQPIVDYIDAQFEAYLQEELKIKRSLFEYHDSRIHVCLYFISPTGHSLKSLDLLTMKNLDSKVNIIPLIAKADTISKNDLQTFKSKIMSELISNGIQIYQLPADEETAAQANSSINENENHCDFVKLRDMLLCTNMENLKEKTHTQHYECYRYQKLEKMGFTDVGPDNQPVSFQEIFEAKRQEFYDQCQREEEELKQRFMQRVKEKEATFKEAEKELQDKFEHLKMIQQEEIRKLEEEKKQLEGEIIDFYKMKAASEALQTQLSTDTKKDKHRKK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.
Subcellular Localization:
Cytoplasm.
Domain:
The C-terminal half (AA 188-389) is able to bind cyclin-B and shows a self-ubiquitination activity (mono-, poly, or multi-ubiquitination) in a HECT-like sequence dependent manner; The BRAT1-like motif mediates inhibition of the endonuclease activity of CPSF3 by forming hyrogen bond and hydrophobic interactions with the active site of CPSF3: Cys-144 coordinates one of the two active site zinc ions of CPSF3.
Sequence:
MAVVEAETRVFLEVRRRLQSALLILGEPDEGGMNLDISVTPTSLLMRSPDGCTEIRLPAGVRLAPSSCGGLQYISGDGLHLRLRAQAESSPQPISGFNQSLQAQECCSFYCQSCGEVTIKDRKLLRVLPLPSENWSALVGEWCCHPDPFANKPLHPRENDCFVGDSFFLVNSRSDLEQEPKANTKVICKRCKVMLGETVSSETTKFYMTEVIVQPSEGSFPNIPRSQFVQSVIARCLVELCTARSTFRFTIQGQDGKVYILLWVLNSDSLVMEPLSSSGCIRKFPLLEDSLEADSGSAWNAIKVLYQPCIKSRNKELASSWEGDISVHPLTLPSTTCLELLLILSRNNASLPLSLRQMNSFQLWCSHCKT
The following text describes a protein:
Function:
Probable transcription factor that may function in the maintenance of the proper function of the central cell in pollen tube attraction.
Subcellular Localization:
Nucleus.
Sequence:
MAPRQKKPNKSDDDDGDLHRKKQSFFKQRFPGFKKKASELSVLCGNSVGFICYGPDNDLHVWPQSQDHNPQALHEIVAKFNALSDERRKNHACDLNDFPHHLKGLSREELRKHLLHLDSQLLGVREQKIEILKKTLTGSSEKDGARVSENSAISDHKLKIEPNLTDILSEDHLIRVSDKKLGSCDVFDELAYVVRGSRNLNENVSNYESKDAAYTGMDHLGTFGGNYLQEAAAELYQTYNLGNFCDDHVWDLEFASRLPPLHTFSDPLMTTNTCQTMSSDMISI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MSESGEMSEFGYIMELLAKGKVTIKNIEKELICPACKELFTHPLILPCQHSVCHKCVKELLLSLDDSFNDVASDSSNQSSPRLRLTSPSMDKIDKINRPGWKRNSLTPRPTMFPCPGCEHDVDLGERGVSGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKSQISELNLLMKETECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLRLDKFHTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQASFEDYVVNISKQTEVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDKADSYVLEYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSRELVLHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIGDVGITKGKHFWACRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSGHDSGSEDAYFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVSFYDMDHMKCLYERQVDCSHTMYPAFALMGSGGIQLEETITAKYLEYEEDV
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MVRFKNRYLLVEFLLPTSLSSTLDAHYDSMDPIIPKEQALEDNDSEDEEDEEEFSPIPSLRFMVPSILPDSQLGEEGGQGIYRAIRSTVISVFGDEGWGRIASSFRVIYHSPLTTLTFLRVARPHYRLLWSALTFITSLENIPAIPRVIAISGTIKKLQNRGIAYHRAMVGALISAGVDKSKTGISGVGGGKLQKEAEQERQEMERMQET
The following text describes a protein:
Function:
Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor. Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression. Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions.
Subcellular Localization:
Nucleus.
Sequence:
MSMAAGPSSQEPEGLLIVKLEEDCTWSQEVPPPEPEPSPEASHLRFRRFRFQDASGPREALNQLQELCRGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELRPESGEEAVTLVERMQKELGKLRQQVTNQGRGAEVLLEEPLPLETAGESPSFKLEPMETERSPGPRLQELLDPSPKRDSQAVKERGVEKFENQERSVESVSPESTHPPVLLPGQARREVPWSPEQGRLDDREGHWECPPEDKIEESLMGTPSCRGLVQAKEQPKKLHLCALCGKNFSNNSNLIRHQRIHAAEKLCMDVECGEVFGGHPHFLSLHRTHVGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPFQCNVCGKSFSCNSNLNRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYRCSECGKSFSRSSHLVIHERTHEKERLDPLPECGQGINDSAPFLTNHRVEKKLFECSTCGKSFRQGMHLTRHQRTHTGEKPYKCILCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLTSHQRTHTG
The following text describes a protein:
Function:
Possesses carboxylesterase activity in vitro.
Sequence:
MGMAAAGGYGRVLWLHGSGQTGEESRAQVAPYFAAPELASVRFSFPTAPTSSIPCYGGEVITAWFAIPEVPITARTARDEKEVLKAVERVHEMLDGEVAAGTSPSNIFVCGLSQGGALAIASVLLYPMTLGGCVVFSGSLPLSKTFAESIPSEARKTPVLWFHGMADGVVLFEAGHAGCAFLQEIGMHCEFKAYPALGHTLVDEELQYFRQWIKDRLSQGTGVPVPSLSDKMDLQ
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MCAPCHYSKASIDCRGMTSKRAVSLLLLALASASSSSASHVAVKSELWKPQCELAKELRKTAGITISKLSAKLTAIDNLNKMSMRLLLFGQRTSPLDNQVTALALALAAQKKAAKIQSTVSDSVKTGLLATQYSGELAGGIVSAVHFLKHASDGAHYCLNSNGKKGDGRPAVDTTGCATLTATEVSTETGFNKGDINDDGFVKLTALTTTDGAGQTGTCGVFETASGSGSTTAGIQISAGAKVHLAFGAIEGTTSQQPTRPALNKFEGANLEAEQTFFGKAHKSLKALTLDTTENALEDPKAMLKQLATEAEAMEALYTVLSGASPNKKPTEFSAQNQQLKIRYFGADGEKTEKLWEQITAGKTIGAGEDPHKFSNLSEVSTADDLSKALFFYTAATLTATRELKSENSRLKETTAKAEKTQEQICNAIQNEKDCGNNENCKYDKDKTEGPKCILSDKGKKAAEKANQEPGGKDGKTTTNTTGSNSFVINKAPLLLAVFLL
The following text describes a protein:
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.
Sequence:
MSGAGNLRSNRRREMDYMRLCNSTRKVYPSDTVAEFWVEFKGPEGTPYEDGTWMLHVQLPSDYPFKSPSIGFCNRILHPNVDERSGSVCLDVINQTWTPMYQLENIFDVFLPQLLRYPNPSDPLNVQAAHLLHADRVGFDALLREHVSTHATPQKALESIPEAYRPHDNTHEEEPDEANAKDTASDGPVNAGHSKGLTDSSVTPTEDHRVMHDDIAIDGDEDVEAEYEPEEIDL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSKQQRRKGNAKNASSASAHGYLAQGGENFVGLTPEMNIFEMASSNRLSNFSGIDDETRIVMRKLTKKDCQTREKGLRELTNIIAETSSIENCYEHFCGLVPQLSTDGSPTVRLLTMKTITLFLVKLEKSACKGLKKIIPMVLFARCDVTNGVAAAAGAVIRDGFEADKKQKVIQLFAPLVFEMAAKIVQGKHDLSVPVEYDASEDREARKSRLETQSLNVFLSYIKEFGADSTIWEEEARKLFENIAFLKMVFGGTNAALKVQVLNLAYRFKNNVEVILNTPSIVTYIQNHLDSQTFTPECSTAWEGMIILLPSAQFHTKVSLQNGIYPRFLNVIRKKGNHWRVLQHFLLPAVVLLLKEMGSLENNMKVLGTIMESFTDNLPWPTDASINAVLSWFNAFSDFVRWILTNDRINLVVWEKLHPLIVTVTEQAMTFPTKEIAECVTDLLQWIIELKTINEADVSTLLLNIESKIVGAGTENSRLIKHLLTEPGKNIVLSNLHANLLSSPELVDFQIIKNLSCSENDYFNATSQKISNFSFIEKTENFDITQAGDIVRLIKLLLENQEIKSLNISVKNDHVGRRLLLTGGSTIWNKLLKNVPVSTFQNMINYWHEKRNGTAIADAVSFLKEMGVEMDTKQAAENVEFLITLLRKMKSTDVSNEAEKNVLILKLFTAIFESDEDAKSEHYNCLSEHLTSDFNSGQFFEKLFASSEEYDIERILETACRVDKLIDLCEEQTRQNIVNNVLLSGKQCGTIIEQFQFLELEVMSCSTKPTVISTTHQHCYSHLDEHKAKEIVTESARIALFNISSKCECFFLISHEQFFFSDYNSAHQVFGWQVISIISALEKRYSLVALTEELQRSRREIEERLIRSDEVRFKLDDSSPCIFLADAYDMSFEQKKKYIQCQAEPSKVPEHALEVLYRENQTPLDFLMNVFEGGYQMFDFDRSKNYHWMINLMFVKKCIQYGGSIFVAEESGLRDYALCGIVTVLDIHKRSTLQQSTDILGNTPNAFDEDPRLEALTTLFIELYLVLNDSIKNDNHPTQTIEEWKEFYVPTINSLFIRMFRMIRKEQQPTPFVRTLLKAMFTLVEFPTNVPNDSVVTREFVPELSVFKYSLLEESFIAQAFILLSSNVEHVQLIGYAAAKLLVPIMFKTENPQVLDDDQDETEIMVANRSKLNLPVMISKSYPVDHIHKHVGPLLLSLAILPLETTKEFVLNQEQRVAYCDAIDSFFKNALNALMLDQPFDFSQVPIVCKIRKQMYFFQFRYSSHFFTAKSQEREYYLQSDLTASPLFFEKFASRLLFKSITLLPAAVRLFHKNIPNNFKPIFQEVVTKHASKLLIENELNKVQNAEFGEVLKVRTVPVTGQIISEYTVEDTKMKLTIELPRDYPLSVPAMNLDKAIVKGDRAKKWLLQLNAYLFHQNGAILEGIEMWKRNVDKGIEGAEDCTICMMTVHQQTNQLPKVKCKQCKNRFHSNCLVSSFHTYKWFESSNQSTCPLCRNNFT
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLPENMVRLQIISDKSAIDPIITKLLKLGMFQPEDPLYPLGNERIEDARRLITAVQDHVSKLKIIMELGGLVIEPLGSIKVSSWIKAAQDVSEEASKLEERYKELLEEIGRLRSEKDLYQQQLKELEPIKSITVELSKLYSLELFDVILAQVDEDKLRLINQIIGDSNFVYYTRFGEERYIVLIIAEKNINVDKKLREAGVRRYELQEGKSPFQLYNEILERINQINIILERTREELAKKVKTEENYIKNVYGKLLTVRDALNIMNKARVSEYYLQIEGYFPEKHVKKVQNEINNLAFMDYIRPRRYGEKEEPPTLVELPKSIKVLESLVEIYGSPSYWEISPIVFLVFTFPILFGLMFPDFGNALVLLLFSIWFYRYGKKRGSENIPKLSIILIYSSIVAIITGLLARDFFGPLPVGGLREILNNGNYSAGPLYNLWPIPASVSEAIKFLLPFGEYSTSVSIENTMIFSVLLGALALFVSSLLGVIDAIRKKDPEFLFLEKLPLFLLYVVPIFIFMYGITDPANFFTVDQQILGQILNAVLMKSFSENIVGYGIVWWTSFALLYNWAAHAILVKRHDNATWGSAIAMGFIEGGFEGALLLLSNTISFIRVLVFALSHYYILYAFSYMAYLVAPSTTTIGVLINPIAIIILIIGNLLAIGLEGLVVFIQDLRLHFYEMFSKFYEGRGRKFEPVMAYVSLE
The following text describes a protein:
Function:
Involved in the control of flavonoid biosynthesis in fruits, probably by binding directly to natural flavonoids. Binds the natural flavonoid quercetin-3-O-glucuronide with affinities in the low micromolar range.
Miscellaneous:
MISCELLANEOUS: Fruits silencing FRAA3 exhibit loss of pigmentation in mature fruits due to the lack of anthocyanin biosynthesis.
Sequence:
MGVYTYENEFTSDIPAPKLFKAFVLDADNLIPKIAPQAVKCAEILEGDGGPGTIKKITFGEGSHYGYVKHKIHSIDKVNHTYSYSLIEGDALSENIEKIDYETKLVSAPHGGTIIKTTSKYHTKGDVEIKEEHVKAGKEKAAHLFKLIEGYLKDHPSEYN
The following text describes a protein:
Function:
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSLRIHKLSNYRFGASEDEEEEEKAHTDRMEKIKEIFAVEGTVKSVRCIILAHEHNITTILLLKNKNKKKLQMPGGIVRTGEEDEAAIKRILTKKFRIVEGEFDIGDHVATWYRPQFSEYLYPYLPAHITQAKEIEKWYIVMLPEKAHFNIQSKNELSALQFIQIHNNVEYQEKTLLYIPAIMSKYDFTFE
The following text describes a protein:
Function:
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.
Subcellular Localization:
Cytoplasm.
Domain:
The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
Sequence:
MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFIEAIGLDKFFDT
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAPKSQYVLYSLCKFLTIIPFRPTTPLASTSHKIYCSFVVLTSTVLTIVTFLNNKWYSQFHHIKMSVLILIQLNLSTFNLITTLSGVLWKREKWHKLLNDLNTMTNRNGQSGRSATIATTSIIVSAVILVWIMYFWANYFGVVYYLKKYNVAYFHFFLMFAYSTVLSWILSIILVEYSNLNRTVCKELQLGQSIEQMFCFLKDTVDTFNDIFGWPMALIISFTTLYLVNNLDYMFLATASLPGSIFYRLLADAAMVLLIFTSTVFLIFMCDSVVQEAEKLQASVQKIRRIRPNLTAKEDQDLEKLCGVIIENFPQFSVARFFNIGRGTVLNILSTVTTFFIIMIQLDTKNN
The following text describes a protein:
Function:
Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form.
Sequence:
MSQSSGGTSTPTTTATQPTSTSTQTPGTTQLLSTTSTPTTTATQPTSTSTQTPGTTQLPSTTSTPTTTATQPTXTSTQTPGTTQLPGTTSTPTTTATQPTSTSFQTPGTTQLPSSTSTPTTTATQPTSTASQTPGTTQPPGGASSPTTTVTQPTGSSSQTPGTTQPPGGASTPTTTVTQPTGSSSQTSGTTQPPGGASSSTVTSSSSTGSNDPCNSNPCKSPASCVKLYDSYFCLCLEGYYYNNSSSCVKGTTFPGEIGMSVNETTDLEDKNSVNYQTLHSSVVKFFENTFKKTDYGQTVILKVSKDSLMSSRSVMRAATQTVYVSVVNMFGENTKEDEESVASVIKEAVKTDNNVERYFQQDRCDYYGCVKSGSNVCRNGLQCTCKPGLERLNPQVPFCVAPTCSEPCSAEKKQLCLKKDNGAMECGCMAGYRKANGKCEECPFGYSGMDCKDQFQLILTIVGTIAGAFILILLIVFIVSMRSKNKKKSGEEQNLIEDDFHNLRMRPTGFSNFGADTSIFPKVKTGVPSQTSNPYANHRSMPRPDY
The following text describes a protein:
Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKEEAKGASSEDQAQSKKALKKQQKEAEKAAKKAEKQAKLASEQHAEEEEDFAKERYGVPSMIQSQDKPDRVLVRVKDLTVQIADETVWVRSRVHTSRAKGKQCFLVLRQQQFNVQALVAVGERASKQMVKFAANITKESIVDVEGVVRKVDQKIESCTQQDVELHIERIYVISAAEPRLPLQLEDAVRPETEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFGLQSGICQLFRDTLTNKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVDEIADTLVQIFKGLQERFQTEIQTVCKQFPCEPFKFLEPTLRLEYTEGVAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPNNPKYSNSYDMFMRGEEILSGAQRVHDPQLLTDRATHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP
The following text describes a protein:
Function:
Involved in ESCRT-dependent multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MGNPEKLMTQIFDLKFTSKSLQRQARKCEKEEKEQKLKVKKAIEKGNMDGARIYAENAIRKRTEHMNYLRLASRLDAVVARLDTQAKMQVIGKSMANIVKSLDSALATGNLQKMSETMDNFERQFVNMEVQAEFMEGAMAGSTSLSTPETEVNSLMQQVADDYGLEVSVGLPQAAAHAIPAAKEKEKAVDEDDLSRRLAELKARG
The following text describes a protein:
Function:
Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin IB may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the whole cell motility of aggregation-stages cells. Overexpression results in significant decrease in the rate of cellular translocation and fluid-phase pinocytosis and abnormalities in the normal rearrangement of the actin cytoskeleton.
Subcellular Localization:
Cell projection, pseudopodium. Cytoplasm, cell cortex. Note=Highest concentration just beneath the plasma membrane in the anterior pseudopod at the leading edge of the cell and at sites of cell-cell contact in both stationary and aggregation stage cells. Also found in macropinocytic structures.
Domain:
Myosin tail domain binds directly to anionic phospholipid membranes; myosins I could therefore move actin relative to membranes and vice versa. TH.2 and SH3 bind tightly to F-actin; this together with the nucleotide-sensitive site in the head, allows single molecules of myosin I to cross-link actin filaments.
Sequence:
MSKKVQAKQGTDDLVMLPKVSEDEICENLKKRYMNDFIYTNIGPVLISVNPFRNLNNSGPDFIEAYRGKHAQEVPPHVYQLAESAYRAMKNDQENQCVIISGESGAGKTEAAKLIMGYVSAISGSTEKVEYVKHVILESNPLLEAFGNAKTLRNNNSSRFGKYFEIQFDKAGDPVGGKIYNYLLEKSRVVYQNPGERNFHIFYQLLAGASAQEKRDYVLSSPESYYYLNQSQCYTVDGINDVSDYAEVRQAMDTIGLTAQEQSDIIRIVACVLHIGNIYFIEDDKGNAAIYDPNALELAASMLCIDSATLQNAILFRVINTGGAGGAGNRRSTYNVPQNVEQANGTRDALARTIYDRMFSWLVERVNQSLSYYKSPYQNVIGILDIFGFEIFEKNGFEQFCINFVNEKLQQFFIELTLKAEQEEYVREGIKWEPIKYFNNQIVCDLIEGKSPPGIFSLLDDICSTLHAQSTGTDQKFLEKMAGIYDGHLHWRGMTGAFAIKHYAGEVTYEAEGFSDKNKDTLFFDLIEAIQCSKMPFLASLFNEDTGSLQKKRPTTAGFKIKTSAGELMKALSQCTPHYIRCIKPNETKKAKDWENSRVKHQVQYLGLLENVRVRRAGFAYRNTFDKVLKRYKKLSSKTWGIWGEWKGDAIEGCKTIFQDMNLEAGQWQLGKTKVFIRHPETVFLLEEALDKKDFDCTAKIQKAFRNWKAKKHSLEQRAQIAHMFKDKKERQRNSIDRKFTSDYIDFENQFGLQEAMQNAHKKERVVFADTVIKIDRRAKQKNYEMVLTDQALYFVEKSIKKKVLVHTLIRRVGLREIKGVSISTLSDNVIVFHLPEHDQVIENDKKTEIIIVLVEYFKAIGGGSLNVQFSDRINYTLKKGEQKEISFQKSEQCPTLVVKKGGKGLIGTIASGLPSSTDSTPKNYNPNSMSQASSRPAPQQSAGRGRGMPQGAGQPQPQQPQQQQRPMPQPQQGGGARPMPQPQQGGGARPMGAPQQGGAPQQGAGRQLPQPTQQGGAPGGRGAPMGRGAPGGGPAGAGGRPLPTVAKPAPQPSRPTAKALYDYDASSTDELSFKEGDIIFIVQKDNGGWTQGELKSGQKGWAPTNYLQYN
The following text describes a protein:
Function:
In vitro, CyaB catalyzes the biosynthesis of cyclic AMP (cAMP) from ATP. It seems that under the physiological conditions CyaB has no function in cAMP processes. In vitro, it is also able to hydrolyze substrates such as thiamine triphosphate (ThTP) and inorganic triphosphate (PPPi) at a low rate. It has a slight preference for ThTP over ATP and PPPi in the presence of manganese ions. This PPPase activity is probably not of physiological importance.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSQHFQGRFEVEFKYRLSDVDAFTCALAALNPEVMLEDNQEQDSYFDTPEHSLAAEGKSLVIRTMQPSGIQLWIVKGPEADRCEAVNITDADKAASMLRTLGYRQVLAISKRRSIYFVGPFHVTRDHLEGIGDFAELAIMTDDEALLPDYRQQLQDLATRLGLSSAQLETRSYRTLCEQSLTLNSEKVPS
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATSERWKLFQESCKKELGRRLPEFSRLESDEERAKFCLALDCWDGDTLTKLIEKLQSLKGKVGKSTEKANHLRDKGNAAYKAQKFQEAFTLYTDSISYSPVTHVNDDNGTECLSLALANRSAVLFHLQEYKLCLQDIQASIDSGYPENLQYKLLHRKVQALFKLGKKDDAKKEVKGTLEAIEKADIPEDRKEAMRKELKLAGRNISKQEEGKEGEESAEEVKVPKLQYGESQQVAHASGGVEMREEEDKGRMLVAQKAFEPGSVLIVEQPYAAVLLQKHHSTHCHTCVTPVLVPHPCRGCQYVQYCSGTCEEQAWREYHSYECEHWHLLQMVETFAQLSLRLLLTAAARGEKHPSADMESPATASKPSDQAKLCTDKVSPTSDGAKTVQIDSETGSTSEQPGDLSVQTDVIEENPPSAGMESPTTADKPSDQNKLCTDDLSSTSEEAKTDSETESTLEQASNMSQAESTPEQASNLSVKTDSVQNSMQDVELHRGNYSSVYNLMTHTEHHSVEQLLTQMMVSCLMCKCLGVDMCVEVVKKLGLEGGNCTGATEGGGCGENKEGGDCAKSEEGVVCVEKMAALLCHHMQQLRCNAQAITTLQEQDSVSLLEDKQVRLATAVFPTEALLNHSCRPNVFVSFQGKTLIVRAVSHIKPGEELLHCYGPHAGRMVYGERQAALKEQYFFSCSCDACQEQVGNPNTVDMFSAYKCPVCNNAAKLQDKKLVCTSPNCDAQGDTDDIKTTSKKIQDLFVQSSAFLEEGQIQEAVSGLKQCLVLQWKILHPSNKDIARTHDALARCYATSGDCKKSVEHLKKSLSTVELQFGACSVELAHELHKLAQLQFNGQQVAECLDTIERALTIFGCHYGDHHPKSKELRAMKDCLIDVLV
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Sequence:
MATITNADPYKILFEQDIKTATNIPMVTFISNVEEFVKDKDVENVFKQLQEAYQKYKFFESKLSNNISMLTQRSKQLQESLDIVDHVENKSNESFSVQYELSEGVYSSAQVNEPKSIYLWLGANVMLEYSFEEAREVLRKNKDTVDRQLSESIQDLGFVKDQITTTDVNVSRVYNYDIIQKRKLKLSGKTEEEEK
The following text describes a protein:
Function:
Kylose kinase that mediates the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans.
Subcellular Localization:
Golgi apparatus. Endoplasmic reticulum.
Sequence:
MNKRSVIIAGIVASLLGLALGANFYFMYYLSAEEGHLASVRALENMIRHKMRHLKPNYLNRNPRFFMFRNKLLKNYKAAPYENASVLWDIANWWPHENEVYPLYDSSMGQLLETLRREPITRVSNLGRGTQLKLLVRLSHQQKVIFKPQWYPREEVIDGMIYSGKDRHTAEVYAFYLGAVLDFRWTPIVVGRVVNLKKEIYAKGDPELQQTINIETDEDGREKYCLFGKCHYCNEEETVCGDERHNIEGVLIYIVPGTLAKRRSPWQRTYKDDKRAPWEDDMTYCKSLKNKMETIRLLDLIDASIFDYLIQNGDRHHYETREERVVLIDNGKAFGNPNKDHLDILAPLYQCCLLRKSTWDRLQVFSGGVLTEIIDRLSKQDALYPLITDKHKKGVERRLLVVYAVVEHCMDIEGDKMFKTL
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MDPIEDLILHSFSDEDSTDDMELEHSNDELYVTNSDMGGIDMTKSSGSPSVELRFSPSDNDEHYTGICPNMPWDDKPKVVERWLQMYQVCFPGNSLMLSQNYQKCVKVNPTLDNTTLKTSPRRNVHHPVSEGILEDGGPTQLLPGGKKKLFCSQPGHNCMESLYDEAQVVREMILPLEQFLCAAPTGDPNKVWEELSKNDNPPALCGRVFRMGEPTYSCRDCGADPTCVLCADCFRNSEHKQHRYKLSTSVGGGYCDCGDTEAWRQAPRCSLHKCDATASALLLDPAARKKAALDRLDRIAAVNMGDRCRIVIEAVLKYAQELLGSNTNLNLPADLKIKEGDSGSMPVDRRDFGPCGPELYTSVYATAVYNDESHTFEQVIQALQRSLDVSSREAVDLATCIDREGRSIVRCSSFQACNQARSAIERHTSRLPPRALKVCVLLGPFLAHQGHALRLLNWLRKLMGICEGFRLLLADIIMKPITRDSEVSLLESVLLSDTQLWKAARSAWHRLFIAGLLMDPDAKRDFATIFTRHYGRLMSDFISDDHDHSHSVTSLSVQLFTVPTLAQYLMGHHGALAALLRCFLGEIDRRKNLDGLLSFDRSRNQQSFRRAMYVLYDIKYLLSAVPLPELDEGLQMQTQVADDTDSTSGRWSDPLRKGFLQGLSMLLSLLSSMEGMDSVVRQTGQHVEFEAEWEAAFNLHCKLAPVLTLIVQWCASDRKVLLKSTRAALKKFQELQPTEQQPKNAVTLLNFTQLCYDYDVSTQPVSVHLPLSRMISGLLLALPKHGLEWDCSEMTLEAKPTLLQLMEAPLRLQVLMAQVQAGMWRHNGYSLINQLYFYQNVRCRTEMYDRDIVLLQLSAALFDSPDSFLLACLHRFSLLSWAQADFDANQQLLAKQTTSSTKKSNAEEDGLRQTIFIAEEFLRLIIILSLERFTPGIGQVDEDECLSHEVLHLLCVESQGHAALNRALPEDAHHETGLERVADKVAVFRKPLQGTGRGVFSLKPEFYGDYNVYHYHYSREDQSRSEDNVRKIRRGRNEENCCPPPVPIPLAPALRNLVGLMNCQITMHLIHQVLLRTYDLRSRTFSEGQLQAALHLTGLALREEESRQQDKSRPPFDFSVQAQENFRLLTVLESLQTNGRVDVHRPLLMWTIRKFRSVHSAAQSRGSTEGAGGASMEAESAEGPGQESPAEAAARQRKAEMAAARRAAILAQMSAQQKSFIKEHAKLFQETGSSISESGGAPTASNLGSTLSGSAMDLSESPSSAQIFPVCLGPGFTVAPSTSETSYTCIVCQEEHRQTGEQPAMVLASFVQLSTVLRWKNDKAATEEPLPETWPMLIDAGRRIGTHISTCGHVMHFQCWQQHFDSLLGRERRRSYRPRQSASYDVERHEFLCPLCKSLSNAVLPILPNRSASSIRPTGSEAGQADMNIWLEGLQLLADNTREVKYAKTDNTNVYETCGPAEMETKLGSMKSKLFVNVLTARSRPKIAATLKEMASLFVQSVYTTAVAANPNADDIRVPMAIAQATAYTILSTESLLAYQNHSPSTGLAARQEEGLRALLRLVISMESIVTSQEVMKNYALHLLRMVLLPSSTISVLEIDAFGLLLGLFCTLPSLSEPSFDSDVRGVPQFNPILAWHIFRLCLFCHVTQIAATMAPASDDMDMDQPSCSSSTFATSESWQSYLQLLGRPDVTLTTEKWVTEQCLPFFRSSAILFHFITNIPYPKLDDAYDNYAEAVLWLRYLGVESLGQLVSESWARPLLSLWNMSLVPPTAITSDVAVVEAAAAKPRPPWTFPVISSGLIQLPSDYSELINAASLFTCPNSEGDEARTPAMCLVTGKMLCSQSYCCQTELDGQQVGACTAHAQLCGLGACLFLRVRECKLLLMAGKSKGCFLPPPYVDAYGETDQGLRRGDPLHICDASRRKLELLWRSHGLYNEAAKYMENSQALVVTEWHHL