lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required to prevent anaphase onset in cytostatic factor-arrested oocytes. Inhibits the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase and prevents cyclin degradation. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Sequence:
MANLLENFAAHHSMTAGAKKKADHQDTSVSQDSGYSDSLKGFSPDSHKSGNFLETVTEGYENSENIDPTLILSPIKYELSWGADTRESKQLAPLYETPRVGKKEFSLRRRLLISKATSGGNLDFDVSVCSAESCGREKSLRRIPSHEGSLSNSFADSPRDGSYEPIATSTLKTESESGTSCKKWRLSFAQQRSSTLDDSKSDSIPLPEVENISPVQHSLASSTDDSILYEETIFGAPTTPTCNFIVKEEFQTPISNLAANFRFNLCTPDVGHVSDFDISVTEDSAFHSLSLDKSQDSITDHEGSFQELIQKPRETSKAVNNKSRLRKLDRCRRLSTLRERGSQSEVEEEGNEVPVLSSAYKLKVARASVDEENEFSSDESRVHSLLSSDDLTGKPALRVLHEMLLRSTRKRPQQATVQDLLGSSGCFELPEDSLSRLIGRKMGLETFDILAELKNRNLKHILASILDLVNAASICSMCRVSRDWRDVVLQDKSAHQRRKAYIKKLKTEAEQGRQLSFEDSATRLNILSRSALRSVQIQARSAFRTPTSSLTPGDNKSIHSASKHQEYLKVAKTLFTDEALKPCPRCQYPAKYQALKKRGTCSRKDCGFDFCSLCLCTFHGSKECGTGSAKRIPKKEALPGSAQSKRNLKRL
The following text describes a protein:
Function:
Converts GTP to 7,8-dihydroneopterin triphosphate.
Sequence:
MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKDFLFEIEEVGIKNLVYPVLVDQYQTAGTFSFSTSLTKDEKGINMSRIIESVEKHYDNGIELEFNTLYQVLRTLQTNMKQNAAGVDVSGKWFFDRYSPTTNIKAVGNADVTYGLAIDGDKVTRKELTIEATVTTLCPCSKEISEYSAHNQRGVVTVKTYINKDQDIVDDYKNKILDAMEANASSILYPILKRPDEKRVTERAYENPRFVEDLIRLIAADLVEFDWLDGFDIECRNEESIHQHDAFAKLKYRK
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MSQLSSPIVFSMESFTQAMELTHTYQPGVTQQQRQEAEQYLMELRVTADGLNLAFGIINSEPVQDTCCFWAFNTIMHHLPRIARDVDDTKAEELYKTLFSFIYRYFFSSNAPTSVSGASLIGLTATSSSTVNCTVLSGVATGTRQRQSIDYLANKHAQMMVAGLQEFFPSRWRSFFDDAFELINRGASLQQHIRDSVTLYILRLFEYIDERVVSVRERSDRSRDQRARDMELKDAMREHVIPRATAFWHATLCECRQRVPELANICMSIVQTYIEWVDISLFFTAEWINLLYFMLSADTVRGAACECLCGLVEKKQVSAAKLESLRKLNVVDAVPRVVSLVPAPPESDEDVNFTESVAKLVREVSMQFLSLYEHITSNRNNYASWGGVSGARGNHANMSHNSSSAETATSPPSLSCVRSTESLDAEGGIDCTNVDCRNFQGRQQQQHSYFVPDGHLSVEFLGEVQVALDVVVPELLRLLSIRHDVVVDTLIPFIQMYIKSSALREEQAAQLLRALYDHTVIGGVAENEEPFWMDDIIDRRKQMHNIMRLLFRDHPAVVMPHLREVVARAASSASDPTTTSAEGFGQTGVMGQDKDLKSHGIDNISNGRGLNCEGISAAVGGSSNTASSPEEAEAALRYLYELGESFRMEQLRDSSNEFAQLIFAVLTSEHLPQHTCSVVHVSYFEVLDRYCVFFTYHRNYIPLLLQRLLLMPHGVMNSSPNVRARICYLFGHLVQVLKSSLVPHVQDIITALQRILAATEYLLPSNRRDLYEAIGILLSTVPQLPAAGATEGTAMTLHVVQVVRQNLRDASVVGNIACAEAVADGISFLTALVKGLRGGGGGGSSGSGAAVNNATYTSPNKNSSGSGSNACSESIKINNATDGNSVSESTGEAVVAEVFHNVTSDVMEVFSTWHASPSVRDRIVQYFTQMAHLLPFDSMKVYVPVYTSNWLMWMEAVQELIKLLRFLLQFIHRSGPCVAEILSQLMPPLLEKVSAVGELSAEDDQSDIVSETMREQRDVYRQLFAVVHGAAQAQCAHVILFLPSVNLNALLVQLLTAIQLPGETELPKIALQIMTKVTATVEPCCTNNESSGAGRHPLRNDCSQGSTGAAGEAWMKFMLNDALRVVFARMFSPTFDLKDAKSLLFIGETGLLLKALMNKLGPADASLSVMLYETFSPLVGESEATGFISALQQQPGRFSTEMKVRFCNMLKFARQHYAA
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Sequence:
MTNLLLLGFLPSGSEWIIIALVILLLFGGKKIPELMRGLGKGVKSFKDGVNEAKEEINKAKDEIDAPADSAKK
The following text describes a protein:
Function:
Probably a soluble electron acceptor for the integral membrane protein electron transfer alternative complex III (ACIII).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Possibly located on the extracellular face of the cell membrane.
Sequence:
MSWRGSGRSNFRSRSSSNGGSTFSGGSAGGPPLIVMMGLAFGAGLIMLIVMIASNATAGGFVAATPRPTATPRPTAAPAPTQPPAAQPTTAPATQAANAPGGSNVVNETPAQTVEVRAAPDALAFAQTSLSLPANTVVRLDFVNQNNLGVQHNWVLVNGGDDVAAAVNTAAQNNADALFVPPPDTPNALAWTAMLNAGESGSVTFRTPAPGTYLYICTFPGHYLAGMKGTLTVTP
The following text describes a protein:
Function:
Down-regulates transcriptional activation by nuclear receptors, such as NR1F2.
Subcellular Localization:
Nucleus.
Sequence:
MSTGQEARRDEGDSRKEQEASLRDRAHLSQQRQLKQATQFLHKDSADLLPLDSLKRLGTSKDLQPHSVIQRRLVEGNQRRLQGESPLLQALIRGHDSSRTSATQVPALLVNCKCQDQMLRVAVDTGTQHNQISAGCLRRLGLGKRVPKAPGGDVAPEPPTQVEQLELELGQETVACSAQVVDVDSPEFCLGLQTLLSLKLATSLSASSLLPSALGIPTESICDSEALVPHSLLSLPKCTTKSLTEKDLQQMGSRLHPGCRGQSYLLPPLA
The following text describes a protein:
Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Sequence:
MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTGMTASRVFPDPPTLPRAVGLGPCAPCAVSSRSLPRASPQACLSSAPTPSFSLTEGLLLSVGSPGTWRCRRAPRGPRCPLTSLACCTRTLPSTPWEEDLWAWTTGPRPP
The following text describes a protein:
Function:
Probable transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MHKHLHHVSHTIKSYLSTLIALENLKVVAFLISLLSCLVAGSILLFTLYTSSFHEVLGLSYLQINMISSLSALGMYFCLPVLGYLADSYGPALLSLFSIWFFCPSYFVNSYLVSTQSGSVIGFCVCFCFIGLATSSLYFSSLITCARICPDHKGLAISLPITCYGLSALLGAQILKLPYFHRHDVLDLEVVFSFFAWLYLVVGIASFVSSSIVIVESELLFGVTPDEETALLELTPTRSLEPPNHRQRFVSFVKDPSAWILLVSLILNIGPMESYQNNLSSILKHTNGADLPNQVSIMAASSTGARLLLGVLSDYSSKYVCRVWLLVVVIVVGVAGQMSETSAILNGVSYGGMFTIYPTIVASIWGIDIMGSTWGSFMVAPALGSVIFSMFYGRNADSCSDCLSHYFYTTAGAMIVSCIFVLLAWKIWYARGFTRF
The following text describes a protein:
Function:
Involved in disease resistance response. May function as repressor of pathogenesis-related proteins. May function in the regulation of host basal defense responses against viral infection. Transcriptional activator involved in responses to wounding and infection with tobamovirus (TMV). Binds to the DNA sequences 5'-AAAATATCT-3' and 5'AGATTTTT-3' of CYP734A1/BAS1 and CYP72C1/SOB7 promoters, respectively. Acts as a suppressor of the brassinosteroid (BR)-inactivating enzymes CYP734A1/BAS1 and CYP72C1/SOB7, and prevents their expression in almost all tissues. Plays a central role in integrating BR homeostasis and seedling development. Regulates the spatial regulation of BR homeostasis and participates in the regulation of hypocotyl elongation and root growth by suppressing BR catabolism. Mediates connection between BR catabolism and photomorphogenesis. Binds to, and transactivates the promoter of the auxin biosynthetic gene NIT2. Stress-responsive NAC transcription factor involved in ABA-inducible leaf senescence signaling. Required for normal seed development and morphology.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing NAC081 show enhanced susceptibility to the necrotrophic fungal pathogen Fusarium oxysporum. Plants over-expressing NAC081 exhibit abnormal developmental phenotypes such as dwarfism and leaf-yellowing. Plants silencing NAC081 produce abnormally shaped seeds.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA-binding domain and a dimerization domain.
Sequence:
MKSELNLPAGFRFHPTDEELVKFYLCRKCASEQISAPVIAEIDLYKFNPWELPEMSLYGEKEWYFFSPRDRKYPNGSRPNRAAGTGYWKATGADKPIGKPKTLGIKKALVFYAGKAPKGIKTNWIMHEYRLANVDRSASVNKKNNLRLDDWVLCRIYNKKGTMEKYFPADEKPRTTTMAEQSSSPFDTSDSTYPTLQEDDSSSSGGHGHVVSPDVLEVQSEPKWGELEDALEAFDTSMFGSSMELLQPDAFVPQFLYQSDYFTSFQDPPEQKPFLNWSFAPQG
The following text describes a protein:
Function:
Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYDFNLVLLLLQQMCVFLVIAWLMSKTPLFIPLMQVTVRLPHKFLCYIVFSIFCIMGTWFGLHIDDSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSMGGMTALSCMISTIVEGLLGGLVHSILIRRGRTDKVFNPITAGAVTFVAEMVQMLIILAIARPYEDAVRLVSNIAAPMMVTNTVGAALFMRILLDKRAMFEKYTSAFSATALKVAASTEGILRQGFNEVNSMKVAQVLYQELDIGAVAITDREKLLAFTGIGDDHHLPGKPISSTYTLKAIETGEVVYADGNEVPYRCSLHPQCKLGSTLVIPLRGENQRVMGTIKLYEAKNRLFSSINRTLGEGIAQLLSAQILAGQYERQKAMLTQSEIKLLHAQVNPHFLFNALNTIKAVIRRDSEQASQLVQYLSTFFRKNLKRPSEFVTLADEIEHVNAYLQIEKARFQSRLQVNIAIPQELSQQQLPAFTLQPIVENAIKHGTSQLLDTGRVAISARREGQHLMLEIEDNAGLYQPVTNASGLGMNLVDKRLRERFGDDYGISVACEPDSYTRITLRLPWRDEA
The following text describes a protein:
Function:
Regulates and controls rearrangements of the actin cytoskeleton. Required for tip formation, morphogenesis, cell adhesion and motility, chemotaxis and aggregates formation. May function downstream of paxB.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MANKNVLSEMDDLMAELGLVETTATPTSDQIKQPQQETAPTYLTYKDPNVSTGPGGDFRNLNDNNGGISRGPGLMSTGPGLVSTGPGLMSTGPGLMSKGPGLPNNSINNNISNNNGGGISSGPGLSFGVSSGVSSGVSSGVSSGVSSGVTLVAQNHLARQPSPPLNSQQQQQQQLPTYLDGVGTLQPISLAATTPDGRVVKANGPICGACGDMIIGVCTNALGRSYHPEHFVCTYCKLPFSGSFIEHEEKLYCENDYLELFSPRCFACIKPIEDTCINALGNRYHPECFSCSGCGDKLRGKPYKEEDGEVYCNTCKIARQKRLAAKSEICSKCKLPITGEYIILQGQPVHSEHYRCEECGCEFNVGKTCHEYEGRLYCYEDYQKQILNICGACSKPIVGRSITALGKVWHPEHFTCTTCQVPFAGSAFREHAGKPYCESHYHQFFGRQCFKCSKPVVDTGVEVFGKIYHREHFTCTGCECVLGKEIMEWDGKPLCFKCFDALPKEVRKRIKEKKAGDKKAEAYREKLAKKEAKELKKERERAAKEKEKESKAK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSDVSSKVSGISPSSSILQNKNGNSKLTNFGSKLKQQVIQPKAIETSDSEYEDKSDDEDSTDGTWQPTKGSTDDLHKSSGLSAGDTSKWNAEEQAAVLNFYGLDTLFPRKWVNDPSLALVTTPMSSNASNPLALGSESPTKLIQTQRVTPDGRLDTSDPLGIKETILRRGKRRESTAFQPGVPSIFISEKSFDPNLFLKEVHRLTLYKEFEQGAVHLKMSIEQRNEIIKGLVKKHFAKFVSAKGTIDTFYREMCQKNLVSSSNYGIAPFAKALEELESNANNLYGPVLGRRSNGDKIRITLGILEGWKFFFNLPSSLIDQINKDKYDGAVRDYKKGKYLMHSSFSDVVQPGKDFRGTKDSSALLPKTHQAVFEKVWNEVERIVGQFRTELFAKLGDSSNSVDAQEKLISYLVDLDSEKSPIMCFLERQYLWLVDKIKDCHKTYISKLYGVRQAFPSRCNVGQNYDTLTSFLNQDTQNESDDKVAEHKSTNEGSSMGINTNNQKAPIAFRRSTDYLSLYDLKQGLSQSIFHNFELLFSNNDDAQAWKLTLRFIQEVCSLLCSRLPDFCRICKLYIDGKLSKTKANDSNRKATQASRIQMVDKIFKSITDLIAAILEDTFGLKMSFSELILMLETQDMSKGNFQDNDTPQDTPPINIQGISIDTLNTDTKRGSESNANKFDAVFEECLIHLEPLAVSHHPSRFAHLISHPLIATHYSTKIVSVLSQMYSEIRHLLFIREDAAISGLSIALTQSQNRLVECICEGFQTTSAQFYMYEDWSYEANSAMSTRSTESVLSDSTSMVKLFYRLSKFLVRTLGYIHSALFYPSTTETLGTVTNTSQLSKESRGYTAITTSRQSMVDKIKFACFESQYLFLDGLQCLATQQSIDNSSFVRLDEQYSVIHPQWVSGNFGTRLPFSSKNADSRWTNKKNRKLIMHSIETRSFVILGNLAFIKTVFIPKMSNMLEQKLRTLVRTEVKSLCDTVDYLDSLLVKNYVRRQMITIKPLLESGILSSGLDWQTLAKTQDVRSYCHQVLLHLVLVHAAISEVSKSHVQRIMSEMLLSLSNCILMAYRSVDSFSTSGMLQATLETEFFHHTLKAYDTPETISVMGMIYDTVERSTVRADQSQTLLNDALLRVKGYLQQSKKSTEVQFACFRDGTNAERDD
The following text describes a protein:
Function:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
Sequence:
MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL
The following text describes a protein:
Function:
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MTPFFIDSAFLTTQPLRFETVSNTCQKPVFYFHNRWRTVTPIGQPLPGTRFIAFKVPLKGAINQRLTPTQKFTPKDLISAIKALNVELGLIIDLTYTTRYYEVKDLPKSIHYKKLYTVGLEVPDNGTILQFKKWVRKFLWENAENEKLIGVHCTNGINRTGYLICRYLIDVEGWDPNTAIQAFGEARGHRIDGCVYLKDLKTQPMRSNLGMDVWDSDEDVPPPAMEGSRDWPPNEDPPGARKRLRLNDDQHRHDHHDLPLKDFDYINKETGQRCRTYYEYEELQEEERHQSDDWDFENEEPGPRNRLFTNHRHYDDFQEEMELKDLDFNNKVTGSRPRPFHDQRTHDVFQEQIPGDDFNFVTKSRGQRMRPVHDHQAYGDFQERLPGKDCDFVNSGQGQNRRPFHDRHSHGDSLDQLPGKDFEFFHRGDGRGQKPFHNPHSHPEMRAKVHLGDGDYPVERLGQKPRPFHSHPSDEHFQEKMPRKDFDVVNRSRGQRPPPFHGCQSHREYPKQMHLRDFDFRQGTVQRRRSYPDWDRSSYEESSQEYRPLEDFDFIYEAPRSRQRSFHDHSPQEDLAPQWYLDRNSGPGNGSGRSHRTICPEDSRRTRPSSEFNRGGPNRFAPYPSRMFPSSSIAQEDGSGDYSRGENTGAVDYKRSPVVTIDYNYDCRPDEDDRELYDLPLRDHCDWS
The following text describes a protein:
Function:
Cyclic phosphodiesterase that hydrolyzes the cyclic phosphate of 7,8-dihydroneopterin 2',3'-cyclic phosphate (H2N-cP) and converts it to a mixture of 7,8-dihydroneopterin 2'-phosphate (H2N-2'P) and 7,8-dihydroneopterin 3'-phosphate (H2N-3'P). Is also able to utilize other phosphodiesters as substrates in vitro: hydrolysis of bis-pNPP and pNPPC produces nitrophenyl phosphate, and that of 2',3'-cAMP produces 3'-AMP. ATP, 3',5'-cAMP, GTP, 3',5'-cGMP, and 4',5'-cFMN cannot serve as substrates.
Sequence:
MERLIKLAEQIKDEELRKKVIEFLKNPKATHPGIVDTGISVEEAPASINWHHRYEGGLIEHTISVTKIALKMADVLEEVYGVEVNRDYIIAGALLHDIMKPYNYIRKEDGTFDHYDMFNLDHLTLAVAELYKRDFPIEVIKIVASHHGDHSPTRPNSIEAYIVHYADEADSKINDVAVRVCQARSRDLGISEQEIYKAVNPLKVYEVRSREGKLKTIEFLKDILKSIGIISEDEKKDENNESLENKESN
The following text describes a protein:
Function:
Probable ATP-dependent RNA helicase.
Sequence:
MLCRVFKAHLKAEMESKNLPIYHQKSKLVQAVRENSFLIVSGETGSGKTTQLPQYLYEAGFCKDGNIGITQPRRVAAITVAQRVAQEMQCSLGKEVGYQVRFDDFTSPSTVVKYMTDGCLLREVLADPGLSAYGVIILDEVHERSLNTDILLGLLKKVFSNPSTATKGRSFPLKVVVMSATLETDKLSVFFNDCPVFTIPGRVFPVTCKFGTAVGPKDLESTGYVKEVVKVALNVHTTEMAGDILVFLTGQVEIERACDLLFEKAESIDYRYDVYDQTVEGLLILPLYGSMPTDQQKQIFQPPPPGIRKCVVATNIAATSLTINGIKYIVDSGFVKQLNHNSRVGLDVLEVVPISKSEACQRAGRAGRTSAGKCFRIYTAEFWEKCMPEYTVPEIQRTSLTAVILTLKCLGIHDVIRFPYLACPEERFILEALKQLYQFDAIDRRGRVTKLGELMVEFPLHPGLTRALLKAASLGCQDLLLPVAAMLSVENIYIRPGEPEKQKEADTRHKALAAKTGSMNDFALLLTVFQSCKSSDRPSAWCKDNWIHWRALKSAFSVETQLREILLRLQQKRDFPVETFDGNKSELFRQCLCTGYFTNVARRSVGKVFCTMDGHGSMVHIHPSSSLFDQEAELNWVIFHDVMVTSRVYIRTVCPIRYEWVKDLLPKLHEVDVYELSSVARQEVTDDEMKKWETKEAAKRQQDVLNEDAMKKLEKRNNEATVSDARARYLERKKQREQSKAL
The following text describes a protein:
Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Required for the inactivation of zip1 via ubiquitination.
Subcellular Localization:
Nucleus.
Sequence:
MTTGYESVPTSEPSDNLAPRAELWQRHLLEKKEGDQSISVSAFNISSMHNELSGLSEKSRQRVEAVWAAFSEASCSERKLALQGILNNCSSSLLSFASSTLDSLVRLDFLSLLPVEISFRILSFLDARSLCQAAQVSKHWKELADDDVIWHRMCEQHINRKCEKCGWGLPLLERNTLYAAKASIQKRYERLTKRGVDQAHESSPVKKAKLDDYPTSSNEETISSVKPPSPNSDSKFFLPFKTRPWKEVYAERCRVECNWRHGRCRQVVLSGHSDGVMCLQLVRNILASGSYDATIRLWNLATFQQVALLEGHSSGVTCLQFDQCKLISGSMDKTIRIWNYRTSECISILHGHTDSVLCLTFDSTLLVSGSADCTVKLWHFSGGKRITLRGHTGPVNSVRIIRDRGLVLSGSDDSTIKIWSLETNTCLHTFSAHIGPVQSLALADSRLFSCSLDGTIKQWDIEKKKCVHTLFGHIEGVWEIAADHLRLISGAHDGVVKVWEACECVHTLKNHSEPVTSVALGDCEVVSGSEDGKIYLWLFNNAPNESPVSTQSVPISSLNGQRSNSSVQRALSSVPNYSSSLSNISTRNLNIPPSNANNDDVSIQS
The following text describes a protein:
Function:
Promotes cell survival by suppressing apoptosis induced by BAX but not BAK. Increases binding of AHCYL1/IRBIT to ITPR1. Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions. Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis. Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Endoplasmic reticulum. Mitochondrion. Nucleus membrane.
Sequence:
MVDQWRERTTMADPLRERTERLLADYLGYCAREPGTPEPTPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTTRWKKWGFQPRLNEQEGDVARDCQRLVALLSSRLVGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
The following text describes a protein:
Function:
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Sequence:
MATALLPSSPFSDRLRRSFPGVERSLLGSAPSLKFTVHKNLSHAHGLRTRAVYGDVNKVEIPRQWYNVVADLPIKPPPALHPKTHKPLKHEDLSPLFPDELIRQELSDDRFIPIPDEVIDIYKLWRPTPLIRAKRLEKLLGTPAKIYYKYEGTSPAGSHKPNTAVPQAWYNAQQGVKNVVTETGAGQWGSSLAFACSLFGLNCEVWQVRASYDQKPYRKLMMQTWGAQVHPSPSSVTNTGRKILQEDPSSPGSLGIAISEAVEVAATHEDTKYCLGSVLNHVLLHQTLIGEECLSQLEALGETPDVIIGCTGGGSNFGGLTFPFIREMLKGRMDPLIRAVEPAACPSLTEGVYTYDYGDTAGMTPLMKMHTLGHDFVPDPIHAGGLRYHGMAPLISHVYEMGFMEAIAIPQTECFQAALQFARTEGLIPAPEPTHAIAAAIREALHCKDTGEEKVILMAMCGHGHFDLAAYEKYLQGNMVDLSHSNEKVQASLAAIPHIVP
The following text describes a protein:
Function:
Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTHDSGLYSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPFVAHQPVSYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH
The following text describes a protein:
Function:
ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MERAEAGTSAGNMPRFLLALQSQSRTEAERARVQEQDLRRWGLTGIHLRPYQLEGVNWLAQCFHYQNGCILGDEMGLGKTCQTIAVFIYLAGRLNDEGPFLILCPLSVLSNWKEEMERCAPGLCCVTYAGDKEERAHLQQDLKQESGFHVLLTTYEICLKDASFLKSFPWSVLVVDEAHRLKNQNSLLHKSLSEFSVAFRLLLTGTPIQNSLQELYSLLSFVEPDLFSKEEVEDFVQRYEDIEKESESASELYKLLQPFLLRRVKAEVAAELPKKTEVVIYHGMSALQKKYYKAILMKDLDAFENEMAKKVKLQNVLSQLRKCVDHPYLFDGVEPEPFEIGDHLIEASGKLHLLDKLLAFLYSKGHRVLLFSQMTQMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKNFGQQPIFIFLLSTRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIICRKAASKLKLTNTIIEGGRFTLGAQRPAAEADLQLSEILKFGLDKLLSSEGSTMDEIDLESILGETKDGQWISDALPSTEEGSREQEEGKNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQKTLLEKTGQEGRLLRNKGSVLIPGLVEGSTQRKRILSPEELEDRRKKRQEAAAKRKRLIEEKKRKKEEAEHKKKMAWWESNGYQSFCLPSEDSEPEDLEDEAEESSAPLDYADPDSTSIKYVSGDVTHPQAGVEDAVIVHCVDDSGHWGRGGLFTALEARSAEPRKIYELAGKMKDLSLGGVLLFPIDEKESRNKGQDLLALIVAQHRDRSNVLSGIKLAALEEGLKKIFLAARKKKASVHLPRIGHATKGFNWYGTERLIRKHLAARGIPTYIYYFPRSKASILHSQASSSSSSRQLVP
The following text describes a protein:
Function:
Transcription factor essential for the identity of ASE chemosensory neurons. Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase. Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36.
Subcellular Localization:
Nucleus.
Sequence:
MSYHYQMNNNNTDFFDSANYIPQMQMHHGYQDFYASDSTSSMPSSGTTQQALQQTENGIIQGQNGSDHGVAFHFRAYGGWRQHDWNSTSSWSIGNQLEMENGTLTMSHGATNDGNIRNNQQMMTSNHITTDSFRQIPPSGLCYMDPTPSLRLPKKEPLPVQRPMARSTPKPFRCQTCGKAFSQAANLTAHKRIHTGEKPFMCPVCNRPFSQSSSLVTHRRTHTGERPYPCAQCEKAFTDSSTLTKHLRTHTGHKPYVCSICMMKFTQSGNLHRHMKTHK
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGKTSGESRISPGSVRWAADLEDVEPTGEKHEKTKNPKMDSGKAGNNMESKKLAMNGRTESASKISTSSVKVAFFRDQQQSCDTSNSVWTNVRRALRLPSYKVELFSKPLEDIYHHYYEQQKLDRILYIILLVLLVNVALIAMYAAVFKKPSSYTQVSRLIVTGVYGAFYLLLVVLYASKLYPARLMKCLPYLVWLGIFSQLLVDQVLGYDPLTPSDSVGMFAFFSFISYVMLPARLALCAVFAIMISIAHLVVAGTQARMNLNYLGQQLVANTLVFVCANILGAIDYHIADRKQRRSVLETRESLEVKLTLDAQNQQQRRLLLSVLPKHVAEEMTKDFEGDGNPALTDNAFKKLFIRTHDTCSILFADIVGFTELSSKCTAEQLIVTLNELFANFDKLAAKNHCLRIKILGDCYYCISGLDDSCNHALCAVNMGLDMVEHIAHVREEKGVKSLNMRVGIHTGMVLAGVLGQRKWQFEAWSNDVTLANHMESGGIPGRVHISEPTLNSIKDYFEVEDGDGGSRDDYLADKKIKTYLITQAKPIWDGEKEDLDTLVLPPETSPEKRRSSSPPEVANDKDSIIGRDGNRRRTSSYMEDSEKSDASTTSNEKMLNKLLCEVLDERTVGKIQEDMNPVTLRFKNYDVEYQYALEKQDMCSEALSCLCIIMLCCYFVELAILPTSLRSHLVFGIGFLLMFVPTVLTFAVKFPQTCGPVLSVSYLLEGSKPARTLVAALCVIVLAGAELIDFLDCSSRDVSSDMIRTWINQSKSLDPTSEYCEYPQYFSYNGILILVGISVLVQLSHALKVMLMIGVLIAYWIINLVRQDKLFVNYDKYVYFNSGSTFVPKMYFSSVVLALTFIILALHGRQVERTARLLFLWKMEADEKKKEDLYSHSYKRVSVMFASIPNFSEFYSEDNINNGGVECIRLLNEVITDFDEVLADPRFLGVEKIKTISSTYMAASGLRPESEDAEESQNLVDIVDFALTLRDKLDFINQESFNQFVLRVGICQGPIVAGVIGAKKPHYDIWGNTVNVASRMETTGKAGCIQITAQTYETIKDKDFVFVYRGAVRVKGKGQLITYYLTGRKNTSQHVYVVSNVECVVSDVEYVASNIGHVASNVECVVSNVEYVASNVGHVASNAECVASNSGCIVSNAVAVFWTDEIMDKYRNGPGISIVIIETISPILCYIVLFQQFLLLLGTLCPKMTPECIATK
The following text describes a protein:
Function:
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Subcellular Localization:
Secreted.
Sequence:
MKEGQIFGASVCLLLSCAFGPLTAIPEEGEEYANITDAKLPPMKPIHSFCAMKADDGPCKAMMKRFFFNINTQQCEEFIYGGCEGNQNRFESLEECKEKCTRDYPKKTRRLNTTLQKEKPDFCFLEEDAGICRGYITRYFYNNQSKQCERFKYGGCLGNLNNFESLEECKNTCEDALNDLQVDDYRTPLEALNNDSLTLQPTKAPSFFEFYGPSWCLTPADRGLCQANERRFYYNSVIGKCRPFKYSGCGGNENNFTSKKACLKTCKKGFVQRISKDGLIKTKRKRKKQPVKIVYEEIFVKKI
The following text describes a protein:
Function:
Part of an ABC transporter complex involved in ferric-petrobactin uptake. Probably responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSILSAKNLETSYEKLTVFRDLNVEIQEGKVTTIIGPNGCGKSTLLKTMGRILKQKSGKVYLQGQDLHTIPTKEIAKQLALLPQTPIAPGELKVEELISYGRYPHRNNVNKLTTKDKEMIDWALDITKTSEFRTRQIANLSGGQRQKVWLAMALAQETEVLLLDEPTTYLDMSHQLDVLQIVEKLNKEHNCTVVMVLHDINHASRFSDEIIAMKEGEIVTTGSPEEIITNEVLKEVFHIDARVMIDPYNGAPVCFGYDSVVSQEEKIEIYVTS
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
Sequence:
MNTCLRSVPLLPFWYLRSFQTRMLTTTQLNLDSVRSQLNEHVRLVAVSKYHPAESVRECYEHNQRHFGENYVQELEDKANQLKDSCPEIKWHYIGQVQSNKIPKICSIPNLFCVETVESEKHCAAFEKAAAKLNSNNKLKVNTSREEQKGGASPEEAVVLGLYVRRECHHLELNGFMTIGSVENSDKIPNPDFDVLADVRKKFAEAAGVDESSLELSMGMSSDMDTAMKQGSTSVRVGTAIFGMREFIKPQWSLSLQDMKKVEESSEEKEDDSFRPISMKCGVFEDSKGSAYIEMGKTKVLVEVDGPRESPSVASQRGKITVSINEENLRIRAQLESAISAMVHLDKYPRAEFMVNISILSSSGGELAASILASALALVHAHVELFDIPVAAHIIYLPETKSFVIDPPSPLSPSAISITVALLPNLNQLIYTRLKGAVSVSESREALSFACKQSLRLYSVMRKTILSSFQNQPKTTL
The following text describes a protein:
Function:
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MASVNRQKNPTVHLAAGGVSGLVSCVLLQPLDLVFRSLANITLFTTLNDVVKKDGVSGLWRGTLPTILRNVPGSALYFLSVHSLRSTMERLGVTKNTSNLIAGAASRVVIGFAAMPITVVKIRYESNLYTYKSLWNSMSSIWRTEGIPGFFRGFGATILRDAPYAGIYVFFYENFKLILGDLISLEYMLDTFLLVGAINSPVAINLGAGMLSGFSATLLTQPFDMMKTRMQLKPLEYPSLLQSFAKISAAEGMTGFFSGIVPRLIRKSLGSAISWTLYEEVVRQLS