lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGKIWGCVLGLPLWLSSSSRSGVRGAPGEGRISRPILFPSLLFPEFPISKPNPLSHRDEPTALDLHVPKDTPLGDNRAAQEPHQEAPKATKPTEGPPCGPTKGRSREPPRLHQTQPGTTCAECGKSFSHKSALVKHQKIHSGDRPHGCPHCGKAFIQRSDLTIHQRVHTGERPYVCPDCGRRFSVSSSLLTHQRTHIPGREKPNRCPQCGRSFADAAGLDRHLKSHLGGKPYECGVCGKAFAWSSHLERHRRIHTGEKPFQCAQCGRAFAWSSHLDRHMRTHVMVEEEEEEEEEEEGGEDEGLPPPPQKCADCGKRLNHQTDPQRFKHKGTQTSPTGGEDGPSVTPVSPNGDGPSITPIFPTRDEDEPSITPTSTGDEDRSSITPISPTRDEDGSSITPTFPTGDEDGPSTSPSPFEQRSTPLTQTSDLKHCRVHPTERPHRKHRFQRSPALSKHPQTHPEPHAEEPTVKPSHPCGACGKTFGWLSHLERHCRVHTGEKPFRCGQCGRAFTVRSHLERHRRLHRGEKPYWCGLCGKGFAWSSHHDRHRLTHTGEKPFSCAQCGKGFGRSSHRNRHQHAHMERHPGQPERGTQPCP
The following text describes a protein:
Function:
May play a role in proteolysis leading to mobilization of nitrogen during senescence and starvation.
Sequence:
MARLTLVSSIILLLCSVAAGSTFEDSNPIQMVSDGLSGFESSVLRVIGHTRHALSFARFAYKHGKRYENVEEMKLRFQIFKGNLDLIRSTNKKGLPYTLAVNQFADWSWEEFQKHRLGAAQNCSATTKGNHQLTDVVLPDSKDWRRVGIVSPVKDQGSCGSCWTFSTTGALEAAYHQAFGKGISLSEQQLVDCAGAFNNFGCNGGLPSQAFEYIKYNGGLDTEESYPYTATNGLCKFSSENVGVKVLDSVNITLGAEDELKHAVAMVRPVSVAFEVVTSFRFYKSGVYTSKTCGSTPMDVNHAVLAVGYGVENGVPYWLIKNSWGAEWGDNGYFKMEMGKNMCGVATCASYPIVA
The following text describes a protein:
Function:
Probable aspartic protease activated by the transcription factor MYB80. May participate in the regulation of the timing of tapetal programmed cell death (PCD) which is critical for pollen development.
Miscellaneous:
MISCELLANEOUS: Plants silencing UND exhibit partial male sterility with reduced silique elongation and seed set. Premature apoptosis-like programmed cell death (PCD) in tapetum from developing anthers, leading to collapsed pollen grains.
Sequence:
MKTTMNFVFLFFLPLLINAKPKRVTLHIPLVHNGANFYDSKVVSLPLSSPHSQRGLAFMAEIHFGSPQKKQFLHMDTGSSLTWTQCFPCSDCYAQKIYPKYRPAASITYRDAMCEDSHPKSNPHFAFDPLTRICTYQQHYLDETNIKGTLAQEMITVDTHDGGFKRVHGVYFGCNTLSDGSYFTGTGILGLGVGKYSIIGEFGSKFSFCLGEISEPKASHNLILGDGANVQGHPTVINITEGHTIFQLESIIVGEEITLDDPVQVFVDTGSTLSHLSTNLYYKFVDAFDDLIGSRPLSYEPTLCYKADTIERLEKMDVGFKFDVGAELSVNIHNIFIQQGPPEIRCLAIQNNKESFSHVIIGVIAMQGYNVGYDLSAKTAYINKQDCDM
The following text describes a protein:
Function:
Transcription factor probably involved in vascular development and shoot tissue organization. Binds to the DNA sequence 5'-CCGAGTGTGCCCCTGG-3' present in the promoter region Box II of the phloem-specific rice tungro bacilliform virus (RTBV) promoter. May regulate tissue-specific expression of the RTBV promoter and virus replication.
Subcellular Localization:
Nucleus.
Sequence:
MNGGIGDALMQPQHVQVMSSSLPMVASTFVAEPAAAANKPRAAGLPPTPPQVFAAQRAAAAAGGDVCMEESAQGGGGGLPPRKAHRRSSSDVPFGYLAGQHQLLPPKVEAGWGHLGAGAGGAAAADDLFNAYLNLEGLDGLNSSDDRHDEGDSRGSSIKTNGADSSENESEECADDTRGGIRLWSADGGERREGVKRNAAGEPATAPLARHARSLSMDSLIGKFNFTAGTAAAAGNGVALGPNRFSLEFGSGEFTPSEMKKIMADEKLAEMALADPKRVKRVLANRQSAARSKERKMRYIAELEQKVQILQSEATNLSAQLTMMQRDSAGLATQNNELKFRLHAMEQQAQLRDALNEALTTEVQRLKLATAELGDSCSSSSLAQQIQLNAQNQMFQLQQQQATQIPFYQLQQSQQNGAAKNNESKE
The following text describes a protein:
Function:
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Possesses high activity on ceramide analogs (C6, C8 synthetic ceramides) and lower activity on C6 and C8 dihydroceramides. Has weak activity on natural ceramides (a mixture of ceramides from bovine brain) and the synthetic substrate C2 ceramide. Has very poor activity on diacylglycerol and sphingosine. Ceramide is a critical sphingolipid metabolite that induces programmed cell death (PCD) in plants and ceramide-1-phosphate has a PCD suppressive effect. Thus, ceramide phosphorylation plays a role in the modulation of PCD and CERK activity is crucial for the maintenance of cell viability.
Sequence:
MEEGRDDEYCSFSNSGDRDGGLSGCFFLDHVGQVLLSRNHDGLSWKCLDSSDCEGTTCLGIIICENSETEIKFSDIYAVEFVSYGLVHSPKLGLRHAKECFRERLLNTQEMYRFTVHGFQSSPKEPCLWNLAAFTFGHMDLQTCQSWMDQLNYSLIKEVERPRNLLVFVHPKSGKGNGSKVWETVSKIFIRAKVNTKVIVTERAGHAFDVMASIQNKELHTYDGIIAVGGDGFFNEILNGYLLSRLKVPLPPSPSDSFNSVQSRGSSSVPEPGDEVHETDQKEHYPLLPDSVQEVMNFRTVNGSCEGIEDPDHPFSSERPRFGLIPAGSTDAIVMCTTGARDPVTSALHIILGRKLFLDAMQVVRWKTASTSTIEPYIRYAASFAGYGFYGDVISESEKYRWMGPKRYDYVGTKIFLKHRSYEAEVMFEEAESENSKASLHTRSKTWPFRNTTRSEKILCRANCKICNSKVGWNSASTTLNPCPEKTRWCRTKGRFLSIGAAVMSNRNERAPDGLVVDAHLSDGFLHLILIKDCSRPKYLWHLTELAKRGGEPLNFEFVEYHKTRAFTFTSFGEESVWNLDGEIFEAHQLSAQVLRGLIPLFASGPEI
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome.
Sequence:
MEGLVVAAGGDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMCSRYDSIPVSTSLLGDTSDTTSTGLAQRLARKTNKQVFVSYNLQNTDSNFALLVENRIKEEMEAFPEKF
The following text describes a protein:
Function:
Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.
Domain:
The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners; The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity); The B30.2/SPRY domain-binding motif mediates recognition by proteins containing a B30.2/SPRY domain.
Sequence:
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGKNLLLNIDALTLGDSVLKPEEVLKFYAYTTKMHKEDLASELLKFDDVHLEPPQGLPGVKPPQDVESRELETYEEIVRALERASVLSGIPLSLIVKSSERNSTGGNDSKSLISELDGIVGEYLKIKKEIELSKKAKHLLKERSEKMKEIEEKLSEIEGKILSYYSAALEVLEEDPSKLRLGRALLEIDRGLLRSSSLLKMASDKSLSLEDLNEIIKNIRESLKETKIRINELSSEAKNLTEISKISEKIEEIMGKMDYILNKIAECNSKKEKLAELRVVDSLWKKMRDSVKRVPELSPIIAEREPVISKVSQQMSILEEEIDAIDSEIRGFIEKISDEFSNIRKDFSTIREGLLSIKVVVAGEAERRVSELIENAKPLIAERGKIEEEVENLSKLVDKNYIKDLKKKEKDLKSKIIEISAELAAIALSLREKALMQRIGMLMYEGEEICVISGWVPKSKKESFERKLEERLGEFLALEFEESEWEEAPSRIRIPNVIKPIRLLTHKLYGLPSVRELDPTFLTAIFFPLMFGMMFGDLGHGITLALFGLFLWKKTSGSMKELGGILLYSGIAAAIFGYLYGAFFFMSITEHPILSPLHDTMRLMAVALIFGAFQMSIGFLINTANKLLERDLFAAFLEYRGLMTFIMYAGAVYAAIRNNASIGGTLSDPLFQAMSIPLMITCVAPVIRSVREGHGVGEGLSEMISTLLESVLALFSNSLSYIRLAAFAVIHEVFGILTVQLMFGKEAIMVNEFASLLSPLALIGFSLMNILVMGLEGLLSFIQATRLTFYEFFTKFYRASGREFRRASELIEPLILE
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASAAPPLLPTTVPAAAPATVLPAAPDAAATSIASPDPAATRAFLGRIYDSAKRSLSGARPWPELLDRAALSRPDSLSDATARLRKNLAYFRVNYAALLALSLAVSLLAHPFSLAALLALLAAWCFLYLLRPADAVPLNALGRTFSDRETLGGLIAASVFVVFLTSVGGIIFSALALGAAVVCAHGAFRVPEDLFLDEVPDQGLVGNGATLNLLSFINGAAGGGGRV
The following text describes a protein:
Function:
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity.
Subcellular Localization:
Membrane.
Sequence:
MNYYDCYYYDYDYDDDDDDSSEGRRRPGSRPGVTGGDAPSGRQGSVASARGPAAPLPLSLPSPPPPRRGAPGMATALESGLARLLFYPTLLYTLARDKAPGKAHRPCFHRIDRTVLLGALPLKARTRQLVEEENVRGVITMNEEYETRYLCNSTQEWEAAGVEQLRLSTVDLTGIPTLENLQKGVRFLLQHRARGNSVYVHCKAGRSRSATMVAAYLIEVRRPPPRLSPPSPGRLTYPLLPLPVPSLNGKRPGLGKDRFLSSSSKERDPSTERPRRATRTPEEGTVPGFGAGFPWRRDHRYFRICVFLSADAGILAGQPVL
The following text describes a protein:
Function:
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.
Sequence:
MPSPTPNECKLTVSNGNNIGKAAKLYRNIGKDTKSRVSSPSNGVMREPAITTMNGAPVLKPASTQRIGNQLRATLLLQDINLLELIQHITHERIPERVVHARGTSAYGYFEVTDDISDVTSAAFLNKVGKKTELFCRFSTVAGRAESAETVRDTRGFAFKMFTEEGNLDWLFLSTPVFPIRDGAKFPSFTHATKKNPRSGLPDHKAFWDYFTHNQEGIHFLMFLFSDRATPVDFQHANIFSINTYKFTKSDGSFTYVKIHLKTNQGVKNFTQDEANQKAGVDPDFQTRRLYEDIENRKYPSWDVYAQIIDPLKAEHYHINIFDATKTFPFSEFPLRKFGKITLNRNVDNFFAEQEQSAFSPTNLVPGWALTPDPIIQTRALAYADTQRYRLGANFIQLPVNAPHNKPFNPVIRDGAAVINGNLGGTENYFPSSFYNVGVAAQYAQPDEEQFQGTVVNFESQVVDADYLQPRIFWEKTLASEPGQQDNFISNVAGHLSAVTGDKGIQIRQAVYAMFGKVNADLGKRIQTSTEATIKQNETGTMTNGMENVKITKQNGIPNGNSHNSETRSRGFAANDCPRPCHAGE
The following text describes a protein:
Function:
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Sequence:
MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTADGVAVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRELEEETGYKGDVAECSPAVCMDPGLSNCTIHIVTVTINGDDAENARPKPKPGDGEFVEVISLPKNDLLQRLDALVAEEHLTVDARVYSYALALKHANAKPFEVPFLKF
The following text describes a protein:
Function:
Channel-forming protein essential for import of protein precursors into mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MSAEPTASSSHLDLSTAQVIKTPITTATGSLLSSNAYEKTSTTSSTSFLGPVHEFTARISKWRDSLNLPDPGTYEQVGREAKGVHLTNYIFDGARAELAKALSLSPAFNVTHSFNMGAQGGAMGGIHPGTYSFGGMYATNNVFAQGTIDSDATLMGRFNYRWGSKDISKLQIQWPSNPTNPSVTQVEHERHGQDYALSMKAYNPNISNQSGIFITQYLQSLHPRFSLGIESVWQVMPPMEDASMSYLMKWQSAKREWISTLTLQATGPLQASYWQKLSDQVEAAVDLHFLPHPSPRERKAVSTVGLKYDFRQATVRAQADSTGKVSMLLEQRIAPMFTFSVAGELDHAKSQSKFGVGIQLESSPLDENSLKGLTPPSPPM
The following text describes a protein:
Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Sequence:
MVDSNASPGSPEETQNPIPDGNEPEHDLPLDAITRKVQESLSLGKRHKFWETQPVGQFKDLGDTSLPEGPIEPPTPLSEVKQEPYNLPNPYEWITCDIDSDEMCDEVYNLLTHNYVEDDENMFRFNYSKEFLRWALRPPGYYRSWHIGVRAKSSKKLVAFITGIPARIRARDNVVTMAEINFLCVHKKLRSKRLAPVMIKEVTRRVHLENIWQAAYTAGVVLPTPISTCQYWHRSLNPKKLIDVGFSRLGARMTMSRTIKLYKLPESTVTPGFRKMEIHDIPAVTRLLRTYLNQFVVAPDFDENDVEHWLLPKENVVDSYLVESTETHEITDFCSFYTLPSSILGNQNHSTLKAAYSYYNVATRTPLLQLMNDALIVAKRKDYDVFNALDVMQNESFLKELKFGPGDGKLHYYLYNYRIRHELRPIELGLVLL
The following text describes a protein:
Function:
Member of the two-component regulatory system YbdK/YbdJ.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQKVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVKK
The following text describes a protein:
Function:
Polymerase alpha in a complex with DNA primase is a replicative polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MEDWVSCRSEEQKRCGEKGQSTFDESEEEQWRKLKEEAMIDSDDSEGAAGDEGAVVLAEAKRRKPRKSGKVIATQKCAQPQNQHRHQQKLTKSLSTYDMENLLKQYRNISAEEEDEVDVDITKFLQDDGVDSEDGEGPSVTATELLSSLISGRSADTNKTEELADSFPLANLNDEVFTYENEAAVKKTPRNKEKRTNKAGANYVIKETVVEELNVVTDLPVEVRTGSQHASTDFLNGCPPKALFYWFDAKEQPHTLTAPGTILLFGKVCVNEEDEEFRSCCVRIQHVHRNVFLLPKEGSTDAEVVQEINAICRGSGIEERRIKFVERYYAFEEPGVPREKNRWAKLVYPGRYPPFPNKGGLTHVQVVVGASRSLLELFLIKKRLMGPSYLEIEHLVTAMDRVSHCKTEFLVPSPKDIKVYNSSKPPPPFTVASIQLHAQLDSDGVKNEVIAASIALYGDVSIDGERKPNITECFTGVRQLSPDAPLPLDLETYCLSKRMPGVHRFINERALLTWFAETLAALDPDIIVGHNIIGYTVETLLNRYQELNIVRWSTIGRLDVRRFPRIQGNNFNLAIEKEACVGRLVVDTYLLAREYYKSTNYKLLSLSTQMEIKGITDNRGHFEPGSTVLVKDSMMSSEALCPILLQLLNCAVLSFNVASFLDVIPLTKRLTLLAGNLWSRTLYGARSERIEYLLLHAFHNLKFVTPDKKKRDLKRGREDDDDEGKRKTKYQGGMVLEPKSGLYSEYILLLDFNSLYPSLIQEFNVCYTTIDRDENTVSAEVPPPESLICLSCRAAGLPSPCLHKCILPKVIRGLVDSRREIKRMMKSERDPGNLAMLEIRQLALKLTANSMYGCLGFEYSRFYAQPLAELVTRQGRLALQNTVELIPQISPSIRVIYGDTDSVMIQTGIKDDIGKVRNLGFEIKGKVNQRYQSLELDIDGVFRAMLLLRKKKYAALSVVDWQGEGKVYKREVKGLDMVRRDWCPLSQHVSDAVLKRILNAEGGEDILDFVIKYMKGVAQDVRSGNVYPLEEFVISKSLTKEPESYHGTGYPHAVVALRMKQRKEGVRVGDLIPYVICEGDEHIDDKAYHIDEVRRSDGLSVDVEWYLSSQLYPPVMRLCEHIQGFVPEQLSEAMCIASHMRTERDVKEEDTANDFSHCSIFKSRALSECFPTATALQVQCTHCQLVVPVDPHKYINDMFSSREKPPPTAPFELYVCFNCGRSLPLAYLANCMTQMCHTIIRQFYCSGGNVASVRALRAQFTYLRAMFDVPQALNCPSAVKNAHRVLSLRCLGTDRKLYTLADVERFPDVEPVDPLLACAESFYRRIDHLFVSLDKLFDTP
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Domain:
The LID domain closes over the active site upon ATP binding.
Sequence:
MTQTIFMVGARGAGKTTIGKALAQALGYRFVDTDLFMQQTSQMTVAEVVESEGWDGFRLRESMALQAVTAPKTVVATGGGAVLSSENRAFMRDHGRVIYLRASAAVLAKRLAEDPEEAQRPSLTGKPIVEEILDVLASREALYQDVAHHVLDGTQTPSLVVEQILQMLTGEMVK
The following text describes a protein:
Function:
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Sequence:
MSADVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDTLAAVKVVKLEAGDNFAVIQQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKVSFRSIHRDIKGANILLSSNGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMLCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWSPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLGSLSARMTRDLLDKVNGAPSDVYDRMSKTVDDLTEEESDMDDAPPLLTPDAAPIKIGLPAHLNGLRLDAKCLEQLTSSPHSTSSETDRKTPTATPRGLNRGYHSERTLPAKEMQSLPDVIGGDALLHCASGNGVIHDDDETIRAPRAPPRTLRAAQKAAASGSENRFSSTSIASTPSEDSMSTFFGMPIIPKVPMGACFSKIMDGTDLKINCAASWVHPLTGAHLLLFGTEQGIYSFDTNCLPDGNLTKIHHRRCSWMFVYSDRLTAIQGNTPYLYRHDLIALTQKNLTLKMSKNLNKIPEKYVPKRLAITVRMPETRGALQCTVKQGEGAQSSSLFLCCAVPKTVHLFQWYKPMNQFVLVRSEPLREDIRFPIRPFALVNSRASDFPELCIGVGRMSGASEFQFNMVNFCSSTRNSEVSDGYNSSFGSLAEDEMLEVGNMHQIDRNTLCFSFRNKVVMTDLEGFERPKPSIFTFNFHIEYLHVVDETILAFHANGVQGRDLKTNLNTQDLCDVSRLYRVIGDDRVIILRSQLMTARNAGDTLDISLLMGHSDTPTL
The following text describes a protein:
Function:
Required for proper assembly of the eggshell.
Subcellular Localization:
Secreted.
Sequence:
MRLFSLLPLLALLVVQAAGQSEVTSDDPATDAGSTTNSTTDTKPRIPSQDEILGQMPSINPIRTGNPQMDAFYMMFPALGSLLKWGSLFPAYSILGAIPDNLQPTAAASKVVLVLADDATAKTRVARQNPPPNPLGQLMNWPALPQDFQLPSMDLGPQVGSFLAQLPAMPTVPGLLGAAAPVPAPAPAPAAAPPPAPAPAADPPAAPVPDAPQPAILGQAALQNAFTFFNPANFDASSLLGQSVPTFAPPNLDFVAQMQRQFFPGMTPAQPAAAGTDAQASDISEVRVRPEDPYSQEAQMKIKSALEMEQERQQQAQVKDQEQVPLLWFRMPTTQNQDATEEKTLEDLRVEAKLRAFERQVIAELRMLQKIELMAKQMRSSAAAQNGDSPYRISYPLSRTPIHKITRADIEQALRDDYVRRLVNKEAQRRARNSGINTQKANALKRQAKSQDQTLSKEDIVQIMAYAYRMANEQMESEKGKQDKVYAAYRTEQNPMMMQQRQWSEEQAKIQQNQQQIQQNPMMMQQRQWSEEQAKIQQNQQQIQQNPMMMQQRQWSEEQAKIQQNQQQIQQNPMMMQQRQWSEEQAKIQQNQQQIQQNPMMVQQRQWSEEQAKIQQNQQQIQQNPMMMQQRQWSEEQAKIQHDQQMAQQMAQQGLMMTEQRQRQWSEDQAKIQQAQQMAQQTPMMMPQMQQRQWTEDPQMVQQMQQRQWAEDQTRMQMAQQNPMMQQQRQMAENPQMMQQRQWSEEQTKIEQAQQMAQQNQMMMQQMQQRQWSEDQAQIQQQQRQMMQQTPMMMKERQWAEENPQSVQQQGPMMMQQQMPSMMQREVEDEDNKAEDDLVGEAGPQMPENEGTARHKVDALGVGGNKRKKSKSKSAPPTVINYYYAAPQRPVVQSYGTSYGGGGYGSNAYGVPRPVNSYQSQGYRAAVGNDEVDEMLRQHQTMARTINPKQPGEVGGSESQKSNSNPPTTLTPAPQEQPQEHRVHKRLAHFHRFGREAGLNATTSKGCGCGRLDCLCGRSCRCGRRGLESRVVSSRTSGTCQCKASHRNKRSVEYGTLETIDEGSLNELRREYKLGLKEITLSPDEDPAEALMRYNAASIREALERASMEPLEIGGDQYEEDAQQEPMEEEQLQHDPNTEPQYNHKDFVRLTTSTASPITSTTEAATPTGSDSTSEATVTPEVTTTTSTSTTTTTESTKDEGLDMQQDSQAEAESSHVTKSISKQEAEIHQLHSIVEELKNEILKLNLRCSTIISNNVAKEPVTEKNPPVVEEPSKQEDKPKVEEKVIAEEQAPVEQEEELEEDEDSTSISTTTETPSPSGSYSTKPGLSLGSPRVDEQSGSSNKLDYDDDNNWQRILANRGYDTDYLTKSHERQFAQGQNLEMPKNCNYDGNGSQEYGPYPEFQADEPSTDTEGKAKRALSVKQQAQLLNAALNDSGSDSSDGTTTTTTPSPYAMRGKFVRRRSTARRVPIPKIGKASDEVWVRSPRQAKMPQRPKKSMSKPKKQSSQVTTQATVSSTKLDSLVDVLKDLVRLQIQKEKKSSLLRTQSNNLSKTKPKSIKPVKVIKRKRLRRRQHKSIATTIRSPIQTKA
The following text describes a protein:
Function:
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure.
Sequence:
MNQPNPNKQPIVQSTSEQTSNEEVDTVLGRFTLFVKDLSNGLNGSQEVPPSQESVSEEAEVISRKIIVLGQTFDNFDNANDYIESKLWLSYRCGFEPIPKSIDGPQPIQFFPSIIFNRSTIYSNFANLKSLFDKENFTSDAGWGCMIRTSQNLLANTLLKLYPKNEPEIVKLFQDDTSSPFSIHNFIRVASLSPLHVKPGEWFGPNAASLSIKRLASELLQDQEIDGIKIPRVFISENSDLFDDEIRDVFAKEKNASVLILFPIRLGIDKVNSYYYNSIFHLLASKYSCGIAGGKPSSSFYFLGYEDTDLIYFDPHLPQVVETPINMDSYHTTNYNRLNISLLDPSMMIGILVTNIDEYIDFKTSCLDINNKIVHFHPHTLPVQQDSIINQSWEEVQDEEEEFINLNVSKIENEQQQEQGQSTDAPDEFIDIGNQSSSVVSVPSNV
The following text describes a protein:
Function:
Induces TNF-alpha release through human Toll-like receptor 2 (TLR2) signaling pathway, leading to macrophage apoptosis. The signaling pathway involves TLR2-dependent activation of the mitogen-activated protein kinase kinase kinase 5 (ASK1), which activates the p38 and JNK MAPKs, leading to enhanced expression of TNF-alpha and tumor necrosis factor receptor superfamily member 1A (TNFRI) genes. Signals are amplified through classical caspase 8-dependent mitochondrial release of cytochrome c, leading to the activation of caspases 9 and 3. Mediates Ca(2+)-dependent up-regulation of the anti-inflammatory cytokine IL-10. Mediates entry into macrophages in a TLR2-dependent mechanism and activates the TLR2-dependent pro-adhesive pathway.
Miscellaneous:
MISCELLANEOUS: Expression of this gene in M.smegmatis leads to low levels of NO and IL-12, increased level of IL-10 and better survival of recombinant strains in macrophages.
Subcellular Localization:
Secreted, cell wall. Cell surface. Cell outer membrane. Note=Exported to the cell surface via the ESX-5 / type VII secretion system (T7SS). Localizes mostly at the cell poles. Colocalizes to mitochondria in transfected eukaryotic cells.
Domain:
Contains an N-terminal PE domain, followed by a conserved linker region and a C-terminal PGRS domain. The PE domain is responsible for the export and localization to the cell wall. The PGRS domain is required for TNF-alpha secretion and is responsible for the main immunomodulatory properties of the protein. Variations within the PGRS domain alter the levels of TNF-alpha induction and are likely to have an impact on the innate immune response. PGRS domain is also required to mediate cell entry into macrophages. Colocalization to the mitochondria of host cells is dependent on the linker region and the PGRS domain, but not the PE domain.
Sequence:
MSFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAADEVSAAMAALFSGHAQAYQALSAQAALFHEQFVRALTAGAGSYAAAEAASAAPLEGVLDVINAPALALLGRPLIGNGANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAAGLFGNGGAGGAGGNVASGTAGFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGAGGNGGLLFGAGGAGGVGGLAADAGDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGAGGNGGLLFGAGGVGGVGGDGVAFLGTAPGGPGGAGGAGGLFGVGGAGGAGGIGLVGNGGAGGSGGSALLWGDGGAGGAGGVGSTTGGAGGAGGNAGLLVGAGGAGGAGALGGGATGVGGAGGNGGTAGLLFGAGGAGGFGFGGAGGAGGLGGKAGLIGDGGDGGAGGNGTGAKGGDGGAGGGAILVGNGGNGGNAGSGTPNGSAGTGGAGGLLGKNGMNGLP
The following text describes a protein:
Function:
RNA-binding protein that coordinates cell fate specification and differentiation during early embryogenesis. Binds to a consensus pos-1 recognition element (PRE) consisting of the sequence 5'-UA(U 2-3)RGD(N 1-3)G-3', where R is any purine, D is A, G, or U, and N is any base. The PRE motif is found within the 3' untranslated region of many maternal transcripts required for early development. Binds to the 3' untranslated region (UTR) of Notch receptor homolog glp-1, thereby repressing glp-1 translation in the posterior blastomeres in the embryo. Binding to glp-1 3' UTR excludes cell fate regulator gld-1 binding to an overlapping binding site in the glp-1 3' UTR. Binds to the neg-1 3'UTR thereby opposing neg-1 expression and cytoplasmic polyadenylation of the neg-1 mRNA poly(A) tail promoted by gld-2 and gld-3. By inhibiting the cytoplasmic lengthening of neg-1 mRNA, restricts the accumulation of neg-1 protein and promotes endo-mesoderm development in anterior blastomeres. Essential for germline specification.
Subcellular Localization:
Cytoplasm. Note=Localized to P granules in the germline blastomeres P1, P2, P3 and P4.
Sequence:
MADNDFLSGEAIMVFKKEILDSHSDFTRSLSHQSASPEAYDQENVFSQDFQPFMKQDKETQNSASQPTSEQSLANRDPCTVPDDLREEMMRQRRKEDAFKTALCDAYKRSQACSYGDQCRFAHGVHELRLPMNPRGRNHPKYKTVLCDKFSMTGNCKYGTRCQFIHKIVDGNAAKLASGAHANTSSKSPARNAAAHNHSLFVPQGSTDRSMDLNQSLPIRQSDLVRAFARATRLDVSGYNSTAQLAQYFESQFQRIQQLSSHHH
The following text describes a protein:
Function:
Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.
Subcellular Localization:
Mitochondrion.
Sequence:
MFGLTTKRILTLFTKKRQTLVEQKLTEYMIAGEKTDNQMLHFKLQVETATPTLDQLNIMLSNIGKDKSDLLVAGATSIEDALTKYQHDNQLFRRPCLVDWDKGKVSPYSILLQTRDFSKLL
The following text describes a protein:
Function:
Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
Subcellular Localization:
Secreted.
Sequence:
MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVSYKSWGIGAPSSVNPGYCVSLTSSTGFRKWKDVPCEDKFSFVCKFKN