lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MPLQLNSTSWILLCLLLQCLADNPGVKIQITQNGLYYGAEYLISQISSVSLSDITGSVTIASQSMDYSLTQVKMVSFQYSNSSANFIPEKGFQISIYGGNSTVNGTWQLDSSIMQDSGLSILTLKGISATVTLGMRQSNKNMVSIFLISCQSEINGIDFRVEGGVDYVYDAVKGPMENIIRSKVNEMLCSALRLQISDWDQSLSAFLSNMSLSSGLDLSLTKDPIFSKQYAEMDVKGGSDTNISMAGGHPSAPMTFSKLPDSMVQVCISEFSLNVAIRASFAANVFTNLFSGFTSFRNIRTSDLSDFLPEISQHFPEPSPVQIRIYQSTAPTLYVKPSNVTVAFVGVLQTYAMPSNTTRRLLFTATTAFSISSNISVSNKSQANGMNITGSIILSSFQLQINRNESSINIPEDVSNEKGIQDIIKVTFTTFLNEKIGKAGIYIPLDFLRNLSIYMKDRFILLAGDLQMSSDFLSS
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGVFKMMKRRQEYKSSMEIFANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYEEYRILEKRDLTLSDIEPIEQDKDNSHERLVLPPCCSGRCQVPRNLSNLYCVYNHVTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSLSSNEVLSAERLII
The following text describes a protein:
Function:
Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses.
Subcellular Localization:
Postsynaptic density membrane; Single-pass type I membrane protein. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons.
Domain:
The PDZ-binding motif interacts with PDZ-domain of scaffolding protein DLG4; The GRID (GABA(A)R-interacting domain) is critical for its subcellular localization and interaction with GABA(A)R.
Sequence:
MPALLLLVLLASSAGQARARPSNATSAEPAGPLPALLAHLRRLTGALTGGGGAASPGANGTRTGPAGGAGAAARAPPPAELCHGYYDVMGQYDATFNCSTGSYRFCCGTCHYRFCCEHRHMRLAQASCSNYDTPRWATTPPPLAGGAGGAGGAGGGPGPGQAGWLEGGRTGGAGGRGGEGPGGSTAYVVCGVISFALAVGVGAKVAFSKASRAPRAHRDINVPRALVDILRHQAGPGTRPDRARSSSLTPGIGGPDSMPPRTPKNLYNTVKTPNLDWRALPPPSPSLHYSTLSCSRSFHNLSHLPPSYEAAVKSELNRYSSLKRLAEKDLDEAYLKRRPLELPRGTLPLHALRRPGTGGGYRMEAWGGPEELGLAPAPNPRRVMSQEHLLGDGGRSRYEFTLPRARLVSQEHLLLSSPEALRQSREHLLSPPRSPALPPDPTARASLAASHSNLLLGPGGPPTPLRGLPPPSSLHAHHHHALHGSPQPAWMSDAGGGGGTLARRPPFQRQGTLEQLQFIPGHHLPQHLRTASKNEVTV
The following text describes a protein:
Function:
Adapter protein that binds F-actin and dynamin, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation. Does not bind G-actin and promote actin polymerization by itself, but excerts its functions by interaction with other proteins. Required for the formation of organized podosome rosettes.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, dendrite. Cell projection, lamellipodium. Cell projection, podosome. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Postsynaptic density.
Sequence:
MSVNLSKNGAALQAAYKDVLDEKTKTDWALYTYEGNSNDIRLAETGDGGLEELVEELSSGKVMYAFCRVKDPNSGLPKFVLVNWTGEGVNDARKGVCANHVSTMANFLKGAHVTINARAEEDVEPDAIMEKVAKASGANYNFHKESNRGNEGPQGPVGSVYQKTNAMSEIKRVGKENFWAKAEKDEEERRLEEHRRANLEKDRLEKERKEREQREAEERERRFRERAKEIDAQRKHQEEGEKQQTVPASQHSVNPREMFLQKERSLPESGPVSVQPGRLRSPFLQKSACQPESSPPSSPVHRVQEPPSSPVNRAHQTPPESPVPPVSHPPEPTVHVKEQDTASQQEEENIYQDTTEDENIYQDTPLDEPVYETGVEEDRGICARALYDYQAADDTEISFDPDDFITHIEKIDEGWWRGIGPNGHFGMFPANYVELLE
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.
Sequence:
MAKAAASSPLEDLDLSGEEVRRLTSAFQDPEFRRMFTEYAEELTDPENRRRYEAEITALERERGVDVRFVHPQPGHVLRTSLDGARRCFVNVCSNALVGAPSGRPGPGGAAAGSQWSLPYSLAPGREYAGGRGTRYMVYDVVFHPSALALARRHERFRQMLDATALDAVEKQFGVKLDRRNAKTLKIKYKGTPEAAVLRTPLPGGVPARPEGEPESPLPDFPYPYRSPAVAGSSEVPRPRAPSPPEAVLPPAPTEPRYSVVQRHHVDLQDYRCCRDSAPSPVPRELVVTIELPLLRSAEQAALEVTGKRLCLDSRKPDYRLRLSLPYPVDDSRGRAQFHKARRQLVVTLPVALPAARPEPAAAPEEAVCAAGTDGSACASAREGAVGPAGAGAGAGAGAGAGAGGCGGCGGDCRPAGAAGAAAEGPASEPEERDLDARAGRTAGIEEEPPSVAGDAPGDGGGGSPRAAPGNRDRGSSAGRGSAPGALRAETRAIGEAAAREPSDRAMGGPGTRGREPLCPPLQCNQDEEFLTLLIQVPRIQPQSLQGDVSPCRYKLCFSTQDLVYYSFFLQFAPENKLSTREPVASISPNNAVIELAKSPECRGPWREWYYGLNKDSLEERLFVNEENVDEVLEKVPSPPLDQPMTVTPPLIEVLEVTESKIHIHAKLQECSNSEQLHEKDEKVNEGSHLTENREHPATSTTDSDSSIADKVLETDSCGSVVCLQQGSLDVSHMVFGKSQQPESKMEPEFMKEKSLVYPNEEKDDLKEPVITEEKELNGDDRSSLLNKTTVHNLPGLSNIRETNTQDGSVQFIKDHVTQCAFSFHNSLLYDLD
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKNRQGEHSPLRETLITKTLPMPYSTIPTLLLIFNAATTCTANKANDPAAEAATDVCKEHAYLTRLSQHIQGKLNDIKATIRLQKTEARKWRMAAAKAQEQGQKCLLTALELTISDALEANELELERVRKTVNSATTAIKQQQGVIAAALAVSAVHAKMNSGSVHSSTGGGSPYTATLKLVKAKSEDLCKLETDEAKETFGGETPEPQDLFKLDLTDKSKVNKANQLDGIKITAEGGCTTQNSQSATGALNACSFSGASGAVEITKAKPPASAYRTATHFFKSNEDKTACHSDITAADAANEPLKRRAKAICEGVKLTPNTTKISEYSGKSLSGSHAIRTYVRNCWPAFHNIDDPTDNSKAKELIKWIEKGYGETADNFNDKFKSLLEGESTPIRDKGEVESKKITELTSSTEKTNQAVSLMEGIRIKRELEAEKKNIPKAIDTKKPEECKGEKDETKCNNKDGCEYKDGECKVKATTAATGTDGKATNTTVSNSFVINKAPLLLAFLIL
The following text describes a protein:
Function:
Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA.
Sequence:
MTAKLLYELVHEAARAHGDKRAVAFDSSIAARVSLTYDELIFMSDELTAQLRVSVQNHEGAIGLFCHPDVLLPVWIIGILQFPAAYLPLDPASPPQCSLRMINNCRLSFCLIQNELLHSAFSILISVEVCATFCSHRLTLIKIKSEQKENSQANDAPFSSAVTKNIQQGEPLAYILHTSGTTGLPKIVKVPHRCIVPNIIHLRSVFKMTPEDVVFLSSPLTFDPSVVEVFLALSSGACLLIVPSAVKKMPRRLAHVLFKRNTTTVLQATPTLVRRFGKVVLQEEVLSADSSLRILAFGGEPCPSLNLVKSWRQEGNRTHIYNLYGTTEVSCWASWYKVPDEHLCLEDITDAPVPLGEPMLDTVMEVRDETGHLVTEGEGQLFIGGQNRVCLLDDEETVVKGTMRATGDWVQVQNSNLYFLGRKDRLVKRFGQRVHLDALQQMIESFSGVEACAVNLSKDDRLLAFIVLTSGHAGAPLSSEIHHDKHLTQPSEISVSVSPKASPPSLRVTEGEIRHQLSKRLSSHSIPDMMVFIPALPLTSHGKIAIDELMKTCETQRQDKNKQAPQKDTASVRLKLQNLWKECLGLQDDVVVEENAHFMFSGGDSLQALRLFDDITVAMGTTSVGLLEVILDGSFSDLLSHIMTETHDDAVLPSKKRTADYSDSEASGKRQHKEMTTSSDTESPFVVPSLRRTMGFVVVRRAAEVFKWGFQKIPQGIFSDAPDKNYVTNNSVGNDTGLISNPSLELSKSSAVTNMADHLQAQEETLLASESPSSHGGVREDSTGVLPLALRVLWRSDTGRCVDASPMLLVAPDRTTVFIGSHSHRLQALDLSRGEVIWERILGDRLESSAAISSCGGLVAIGCYDRQMYFLDVSCGDTVWTFETGDVVKSSPTVDPKTGLVFAGSHDGHVYALNPLTKTCTWQHYCGGGAVFSSPCVHLSPRQLYCSSLGGHLHCLNPDSGKVLWKYSSSAPFFSSPHCSDSSVFIGSVNGHIIGISHSGNTLWDFSTDGPVFSSPCISSLTLLTNQPPSTTPSSSVTTSPNHIVTCGSHDGHVYCLNAQNGSLLWQFQTTGKVFSTPFVFSGALWGLRTLAAVCSTDGKVWVLDGETGIQKATLSLPGELFSSPVIWGSKLVVGCRNDYVYCLELTTQ
The following text describes a protein:
Function:
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAAAAMAEQESARNGARNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMAQSKHAEARELMCSGALLFFSHGQQNSAADLSMLVLESLEKAEVEVADELLESLAKLFSLMDPNSPERVAFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSSDGEGCANMLVEYSTARGFRSEVDMFVAQAVLQFLCLKNKSSASVVFTTYTQKHPSIEGGPPFVQPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLSSLMGSSEQEGEDSQDDSSPIELD
The following text describes a protein:
Function:
Possible structural role in the sperm tail.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLSRFTSVFPRNVIVRGVSTLTSHVDRNYLVRSSFDKCQRFPFSDSKQEAEDVKKKCEEAAAKKKCAEAAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAKKEQEAAQKKKCAELAKKEKEAAEKKKCAEAAKKEKEAAERKKCEEAAFKQKCEEAAKKKKEAKKAAELQQKCAALAKKEKEAEMMKKCEEAAKKKAAEEAAKKKAEEVAAKKKADEAAAKKKCAEAKKKAEEAALKKMCEEAALKKMCEEAALQKKCAEAAKNAKKTDSET
The following text describes a protein:
Function:
Putative oxophytodienoate reductase that may be involved in the biosynthesis or metabolism of oxylipin signaling molecules.
Sequence:
MKSSPNQLSIFSYLLGICSLDTLLSPVGRKMDAISPLVILRMDNHISSFFSEFQPNGQAPISSTDKQVTPQVSHDGQVLEFAPPRRLKTEEIPNIVDDFRIAARNAIEAGFDGVEIHGANGYLIDQFMKDSVNDRTDAYGGGIENRCRFAAEVITAVAGEIGAHRLGVRLSPFADYMDCHDSDPEVLALRVIGLMNNLGVLYCHMIEPRMCVGAGEDGSKPVIAHGRLLPFRKAFRGTFMVNGGYDRDEGDKAVADGYADLVAYGRLFLANPDLPERFRRKAGLNKYDRSTFYTSDPVVGYTDYPFLDDQNSELATR
The following text describes a protein:
Function:
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Subcellular Localization:
Cytoplasm.
Sequence:
MKIIGGPASQLLASRTARALGTEPVLCEFNRFPDGELYLRIADEIENEKVTIIQSTPTDSDFVALLQLIDACEGAAEINVVIPYMGYARQDKKFKPGESISARAIARCINASRIFTINIHERSILDHFPCPAVNLDAASLVGEYIAGSGLENPMLVAPDEGAQGLVKNVAAGHGFDHDHLQKTRLSGDTVVIKTKNLDVTGRHVVLVDDMIATGGTMAESVRMLKAQGAIDVHLACVHPVLTRNAALRLFNAGVKDIIATDTLEKAESLLSVAPLIAEALKRL
The following text describes a protein:
Function:
Involved in the biosynthesis of mugineic acid family of phytosiderophores. Hydroxylates the C-2' positions of 2'-deoxymugineic acid (DMA) and 3-epihydroxymugineic acid (epiHDMA). May be involved in boron tolerance.
Subcellular Localization:
Cytoplasm.
Sequence:
MENILHATPAHVSLPESFVFASDKVPPATKAVVSLPIIDLSCGRDEVRRSILEAGKELGFFQVVNHGVSKQVMRDMEGMCEQFFHLPAADKASLYSEERHKPNRLFSGATYDTGGEKYWRDCLRLACPFPVDDSINEWPDTPKGLRDVIEKFTSQTRDVGKELLRLLCEGMGIQADYFEGDLSGGNVILNINHYPSCPNPDKALGQPPHCDRNLITLLLPGAVNGLEVSYKGDWIKVDPAPNAFVVNFGQQLEVVTNGLLKSIEHRAMTNSALARTSVATFIMPTQECLIGPAKEFLSKENPPCYRTTMFRDFMRIYNVVKLGSSLNLTTNLKNVQKEI
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MASAPSKLYADDVSLVVVLLDTNPFFWSSSSLSFSQFLSHVLAFLNAILTLNQLNQVVVIATGYNSCDYVFDSSSDLNRSFENGRMPVMCSSLLQKLEEFLIKDEQLSKEEPEGKIKSSLFSGSLSMALCYIQRVFRSGALHPHPRILCLQGSPDGPEQYVAIMNAIFSAQRSSVPIDSCYLGSQNSAFLQQASYITGGVHHKPQNLDGLFQYLMTIFATDLHSRSFIHLPKPVGVDFRASCFCHKNTIDMGYICSVCLSIFCKHHKKCSTCGSVFGQAQSEAASASDKKRKTPET
The following text describes a protein:
Function:
May promote appropriate targeting of ribosome-nascent polypeptide complexes.
Sequence:
MVSEQTPVATAEAELVSSAAVPVKPEEAAAKAQPEDDAPIVEDAKDDDDGDEDDDDDGDEDDGEHGAVVNKGSKQSRSEKKSRKAMMKLGMKPVTGVSRITIKRAKNVRNCTTAANNCTRQG
The following text describes a protein:
Function:
Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress. May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha; Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation. Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways. Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6. Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress. May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLSLTASFVQIKFDDLQFFENCGGGSFGSVYRAKWLSQDKEVAVKKLLKIEKEAEILSMLSHRNVIQFYGAVLEPPNYCIVTEYAACGSLYDYINSTRSENMDMDHIMAWSMDVAKGMHYLHMEAPIRVIHRDLKSRNVVITMDGILKICDFGASRFHSHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPQSFAELMHQCWEADSKKRPSFKQIISNLESMSNDSKLPDQCNSFLHNKAEWRCEIEETLERLKRLERDLSYKEQELKEREKHLKMWEKKLTEQSHTPLLPSFDICAWTEEDVYVWMQQLVKSDDENMYASLFRQHHITGKRLLLLEERDLKDMGIVSKGHIIHLKTAIEKLTHDYLNLFHFPPLIKDFESENDEEEKLVNLELVFGYHLKSGSCPEDYKWKMYMELDGDEIAITYIKDVTFNRNQPDVEPLKMTKPPFVMEKWIVGIRENETVECIVTYENDVRTPKITKHIHKIHWDKMKMQDAVKSVQLAIMSPLLTSESKQSNYESSVDCQWIYTLRMRQMATPTSPQHAAGLPRSQSSSLSNLSQILPYLQNQESYAAAVRRIRASPTLQVTSINYSRSSSPTQFGLAKNLSSLSIQSSKGSSASSTASDSPSERERAHRTPNNSSYQHNRHSTPMQRRSGGRSPQMNSGKNYKSYTVTYSHSRPFEQRPQRTNQNRYIPGMPKLESDAAVNGEEKNNNDGGWIKVDYSKKTHKQTTTSKSHKDRSKSFGRGRR
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MGDIKQNKYDLGLDMTVDDQKKIGKFTNLHYKEPLYEHKIKMMKENIMNIDSSIDEVSLAFDSNDIMLNIGDCFFKFDLDYIEEHLEDRKSEELANLNEMELEYKTKLNEKQKLKTELYAKFGNRIDLN
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Forms part of the polypeptide exit tunnel.
Sequence:
MPKLSLLKQDGTNAGEITLNDTVFGIEPNEKVVVDVILSQRASLRQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYAYKLPKKVRRLAIKSILSSKVNEEKLVVLEGLTFDAPKTKEFAAFLKNISVDTKALIVVAGESENVELSARNLQGITVIPAESISVLEVAKHDKLIITKAAVEKVEEVLA
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGVDGFLRSLRDAVDQTHLQQFKGQTLVVDALSWLHKACYGCAFELSTGKNTDTYVQYMLRKVEMMRGCGVAKVILVFDGQRLPLKSSTQKKRQNYKEVNRKRALQSMAAAKRMQGNDRQDEFNRAYQLFQRSVSITSEIISTVMDALRAARVPFVVAPFEADAQMVWMCKEGLASGIVTEDSDVVVYCLTADVSSPVLVKLEDNGSVQAVSRPILHRNSGKASSNALLRKIQFLTSGDKEATRMFVQVCVLAGCDFIDSLPNVGFATAVKHIFNFRGAPGHLRVQRLVSKLSSSGTKIPSDFMPQFLKAETIFFHHIVFNPTKHILQRANESLGISSAEDELDLTSTAKQEDLHKTATSTTSFLGQVHSRGIIEQIYRGEVCPRTLRSTPGAPTSSQDLQRSDGAW
The following text describes a protein:
Function:
Threonine aldolase involved in threonine degradation to glycine. May play a role in the removal of L-allo-threonine.
Sequence:
MATKVVVDLRSDTVTKPSEAMRASMAAADVDDDVRGADPTARRFQEEMAALMGKEAALFVPSGTMGNLVSVLAHCDVRGSEVILGDDSHIHLYENGGISTLGGVHPKTVRNNSDGTMDIDSIVAAIRPPGGGLYYPTTRLICLENTHGNSGGKCLSAEYTEKVGEIAKSHGLKLHIDGARIFNASVALGVPVDRLVRAADSVSVCISKGLGAPVGSVIVGSKAFIDKAKILRKTLGGGMRQVGVLCAAAHVAVRDNVGKLADDHRKAKALADGLNKIEQFRVDSASVQTNMVFLDIVDSRISSNKLCQVLGTHNVLASPRSPKRLVLHYQISDDDVQYALTCFKKAAEQLLMGSTELEHLAEQLLMGTTKNSYGQ
The following text describes a protein:
Function:
Receptor kinase that detects X.oryzae pv. oryzae protein Ax21 to promote innate immunity. Following X.oryzae pv. oryzae protein Ax21 detection, undergoes cleavage, releasing the processed protein kinase Xa21 chain; The processed protein kinase Xa21 chain released by protein cleavage after X.oryzae pv. oryzae protein Ax21 detection translocates into the nucleus where it can bind and regulate WRKY62, a transcription factor. Confers resistance to the bacterial pathogen X.oryzae pv. oryzae (Xoo).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MRNSKPPSKLAMLMALLSLSFLFCYGVEKVHCSTVHENNQDFHSLLDFKKGITNDPNGAMSNWTNNTHFCRWNGVKCTLTPPYRVMELNLTGNDLAGRISTSVGNLTYLSLLALPNNRFSGPIPPLNKLQNLSYLSLDNNFLNGVIPESLTNCSNLDTLGLSKNNLTGVIPPSIGSLTKLKVIFLYKNNLSGVIPSSLGNITNLSVIALSENQLNGLIPTELWQMPHIASLYLFCNNLSGEIPQTISNLSSLQELSLAVNMLSNTLPSNFGHALPNLKLLYLGGNLFEGQIPDSLGNVSGLVHLDMSYNKLTGKIHSIFGKLLGLSFLNLEENMFEASDSASWDFFVDLIACSSLTVLSLASNNLQGAIPNSIANLSTNLRNLLMSDNHLSGVVPPSIGKLNGLIELELDGNNFTGTIEDWMPKLTSLQKLYLHDNSFEGTIPPSISNLAHLTLLDFSNNKFTGSIPPSMGNIQLLINLSLSNNNFRGTIPAKFGDLKQLVFLDVSSNELGGEIPNSLGQCQNLAAIKMDQNVLIGNIPTSFSNLKSLSLLNLSHNKLSGPLPNYLNDLKLLNKIDLSYNNFHGEIPKAGILDNSTLVSLDGNSGLCGGAMNLHMPSCHTISRRARTISDLVKILIPMFGLMSLLHLVYLVFGKKTSRRPHLSQRSFGEHFEKVTYNDLAKATRDFSEYNLIGRGSYGSVYSGKLKEVEVAVKVFNLEMQGADKSFLVECETLRSIQHRNLLPIITACSSIDTTGNSFKALIYELMPNGNLDKWIHHKDNEALPKRLSLAQRIAVVVNVADALDYLHHDCGRPTIHCDLKPSNILLGDDMNAVLADFGIAHLYSDSQSTWTSSFSSIGVKGSIGYIPPEYGGGGSVSTSGDVYSFGVVCLEILIGKRPIDPVFIGGLDIISFVKNSFPDQIFHIMDSHLVEECEHLIQDNKVTNEEMYQCLVDLLQVALSCTCSLPSERSNMKQVASKLHAIKTSQIGYK
The following text describes a protein:
Function:
Histone chaperone-dependent acetylase that modifies 'Lys-56' of histone H3 (H3K56ac), to promote genomic stability, DNA repair and transcriptional regulation during mitotic S-phase. Plays an important role in the regulation of white-opaque genotoxin induced-switching.
Subcellular Localization:
Nucleus.
Sequence:
MLPPDILQNGEFETIYFQTNPTYIKSPIHIPKSTIGKPDTVKIRHFFALLHQDLVVLGLEVFVYLQIYSDFVEKYVYVSKCDTVGLEKSTIKIGKVIGPVLQYIINYNGYKIKMKNLDEKSKDLSDPSTLVRLQRLRDKLPDIYPNLPYYNDIPPKEECIEYRTLPKTQNLRLCVFTKPAKEYLFPNSAKNPYKNLLNGQSLLRWWISIIDSITKGWNNHKLMIPGADKYATRKFIEKYSDWSEGHIFKKDGLAVQAIPLFPDDPKGRFLELVIVECRYGKMTVSRFYQELAYRQEFLLGDCVSLIGCCKENLEVTYHDDSVSTVTISEYKEFMNSLKSVDFSDRVEVSNFVSNYRKSK
The following text describes a protein:
Function:
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
Sequence:
MRSRQGVAHPRRRRERRWALSSPLALFRSAGVSILSALLGPSPCSVQSPGDALLVKAPMDAVENAVAPAAPSTVANGTSSAITVEEFEDLASLVKDDEASVSITVVGASGDLAKKKIFPALFALYYEGCLPKHFSIFGYARSKMTDAELRDMVSKTLTCRIDKRENCSEKMEEFLKRCFYHSGQYDSEEDFRELGKKIKQHEGPRVSNHLFYLSIPPNIFLDVVKCASKSASSVSGWTRVIVEKPFGRDSESSAALTKGLKQYLTEDQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRQYIRNVQLIFSEDFGTEGRGGYFDSYGIIRDIMQNHLLQILALFAMETPISLEAEDIRNEKVKVLRSMKPLRLEDVVIGQYKSHTKGGITYPGYTEDKTVPKGSLTPTFAAAALFINNARWDGVPFLMKAGKALHTKQAEIRVQFRHVPGNLYKGSFGTDLDRATNELVIRVQPDEGIYLKINNKIPGLGMRLDRSNLNLHYAARYPKEIPDAYERLLLDAIEGERRLFIRSDELDAAWELFTPLLKELEQKRMAPELYPYGSRGPVGAHYLAAKYKVRWGDLGGSEH
The following text describes a protein:
Function:
GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (By similarity). Also shows GAP activity for RAB18 GTPase. Promotes RAB18 dissociation from the endoplasmic reticulum (ER) membrane into the cytosol, probably through stimulating RAB18 GTP-hydrolysis. Involved in maintaining endoplasmic reticulum structure (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.
Sequence:
MALRPSKGDGSAGRWDRGAGKADFNAKRKKKVAEIHQALNSDPIDLAALRRMAISEGGLLTDEIRCQVWPKLLNVNTSEPPPVSRKDLRDMSKDYQQVLLDVRRSLRRFPPGMPDEQREGLQEELIDIILLVLDRNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVSPELHDFMQSAEVGTIFALSWLITWFGHVLMDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAASTFKDFELASTQQRPDMVLRQRFRGLLRPEARTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP
The following text describes a protein:
Function:
No nicotine N-demethylase activity.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVFPVEAIVGLVTFTFLFYFLWTKKSQKPSKPLPPKIPGGWPVIGHLFYFDDDGDDRPLARKLGDLADKYGPVFTFRLGLPLVLVVSSYEAIKDCFSTNDAIFSNRPAFLYGEYLGYKNAMLFLANYGSYWRKNRKLIIQEVLSASRLEKFKHVRFARIQTSIKNLYTRIDGNSSTINLTDWLEELNFGLIVKMIAGKNYESGKGDEQVERFKKAFKDFMILSMEFVLWDAFPIPLFKWVDFQGHVKAMKRTFKDIDSVFQNWLEEHIKKREKIMEVGTEGNEQDFIDVVLSKMSNEYLGEGYSRDTVIKATVFSLVLDAADTVALHINCGMALLINNQNALKKAQEEIDTKVGKDRWVEESDIKDLVYLQAIVKEVLRLYPPGPLLVPHENVEDCVVSGYHIPKGTRLFANVMKLQRDPKLWSNPDKFNPERFIARDIDFHGQHYEYIPFGSGRRSCPGMTYALQVEHLTMAHLIQGFNYRTPTDEPLDMKEGAGITIRKVNPVKVIITPRLAPELY
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MDSPAWMFTKALSHRQKVTRLYKRCLREVDNWYGGNNLEVRFQKCIIRARFDANKDEIDTRKSQILLADGCRQLWEKRHFKPFRFALDPGGSSYDRERESPDEIVDSDQWTLAEREQFPYYFNTREQRKKELLAHWAKIEKAWDEEIAAIQTQLPAAAPTVSK