lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MIQTEKKWADIDVDDDESINDNEIKKKWEDIDADDDLEANKKLSYFTNYENGIKVVTKYSENLKKQTVKVTKKIQEVVIKKKLNKEINNRLNLKNFNIDIHSSVTVEPTDVVNIEVPKNNPLDFLKDTEYDYLFAEQTNKTAKDLKNRFKILKDEETEDVKAEDPSKAAGRREGLYYRPHDTQNKECTVRVTNLSEDVNENELSNLFGKVGNIVRMFLAKHKETQNSKGFAFITYSKREEAKRAIEKLNRHGFENLLLSVEWAKPSNR
The following text describes a protein:
Function:
Converts protoheme IX and farnesyl diphosphate to heme O.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLMEPKYDAQMSRTRNRPLVRKLISTRGAVVFAIACGVAGVGGLYYGVNPTTAFLGATNIFLYAGIYTPMKRMSVLNTWVGAIVGGIPPLMGWTAAANQYAHDGTWEELLFGEGSAGGWLCAALLFAWQFPHFNSLSWSIRDEYKNAGYRMLAWVNPAQNGRVALRYAILMFPVCIGLSYCGVTDWSFVVTSSAINGWMALKAWHFYKAEGQKGTARGLFWASVWHLPIVMVLAMAQKKGLGERLYRSVFGYSEIDEEDLYYDGEEEETPDEVIVVRRTS
The following text describes a protein:
Function:
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
Sequence:
MSAAALLAPAPAPAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDFVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPTTPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYLGQLQRGLFVIRRRSAA
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MGDNLVYAVRSSQGFYLKRGLGTDAVTVFEQNNSSKEVACNVFAYSNNGQLFAYCDNQVTRVFEIATHKEILCVELKRTRKILFSPRDNYLLTFEPWAIYGAKTSENQKPEPNVRVFSLADGRHVSTFSAPKEASWEPQFSDDEALAARMVGSEIFFYNGMSFDRYEHKLVEKGATSFSLSPGNCPNHVAVYVPAVGSNPARVRVHKVSTGFPVVGNRTFYKSDKAVVTWNPRGNALLILASVDVDKTNQSYYGEQSLYLINIQSGDSVIVPLEKQGPIYAAKWNPNGREFAVCYGYMPAKVTFYNPKGVPIFDMAEGPRNDIFYNAFGNIVLVCGFGNISKGKMEFWDAENKKEIISIEVPNTTLFDWAPDGQHFVTCTTAPRLRIDNCYRFWHYTGRMLAETHFDSPKEELWEVRWRPMMGYNKFAIKELTKTDKMAAGLPIKKKDASHPLNNVPAGAVRQAGAYIPPHLRKPLGGGGAAGPPSAPAAANGNQNHRPAPQRTNGNGNVPQPFRPQQSDQDRKLFQLKKKVDEIQVLKQKQANGDHLQPNQMEKIKREEEYLADIAKLTI
The following text describes a protein:
Function:
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Miscellaneous:
MISCELLANEOUS: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
Subcellular Localization:
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Sequence:
MAEVPELASEMMAYYSGNEDDLFFEVDGPKQMKCSFQDLDLCPLDGGIQLQISHEHYNKGFRQAVSVVVAMEKLRKMLVPCPQIFQDNDLSTLIPFIFEEEPVFLDTRNNDACVHDAPVRSLHCTLRDAQLKSLVMSGPYELKALHLQGQDLEQQVVFFMSFVQGEESNDKIPVALGLKAKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTRGGQDITDFTMQFVSS
The following text describes a protein:
Function:
Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
Sequence:
MHRDKRQRMSDSIPSQKDRKYDRQLRLWAASGQRALEDASVCLLGSSPVATETMKNLILPNVGSYTVVDGGNVTEDDLSANFFFDSDSIGKSKAQSASLLLNELNKDSTGSYLDQKPSKIVASNLSYFDQFSIIVASVSSFDKYSDLEALSEYLYSHYIPLVVISSAGFYGYVRVVMKELPIIDTHPDSLVDLRLDSPWPELMEYVNNFPEPETAAARDHVPMIVLLLKTADKWIKEHEGGLPTKRDEKLAFKKQVEALRQGDSENVDEAVAAVWRLYQKSNQVPSQIRDLFNLSAEDSTDRDPTFWTLVEALKDFVAETGTFPLSGTVPDFKAYTKDYVDIQRVYKDKANKDLSRFKEIVATKVVEVPETVIEEFSKNSRFIHLARGTSLTHDISPESLAQITSEDDDLLKLYYVIRASQMLGGKQDAFSIMTKTNELGVTADVVEYSQEVARYEGRELHNISSVIGGVASQEIVKILAKQYVPLNNTVLFDGIGSKMEKWLL
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion intermembrane space.
Sequence:
MPGQVDLPSAEELSVQELDVSSAVLKAAAHHYGSQCDKPNKEFMLCRWEEKDPRKCLVEGRKVNACALDFFRKIKTHCAEPFTEYWTCIDYSNLLELRRCRKQQAAFDNCVLDKLGWTRPELGDLSKVTKVKTDRALPDNIYHSRPRPEPNPPIEGELKPSKYGSKMFFWTW
The following text describes a protein:
Function:
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTVKFDGRSEQQILDIENHIQAVKILLDDLIRFDIIKAYDEITGVGHRVVAGGEYFKESTVVEGDVLEKVEELSLLAPLHNPANAAGVRAFKELLPDITSVVVFDTSFHTSMPEKAYRYPLPTKYYTENKVRKYGAHGTSHQFVAGEAAKLLGRPLEDLKLITCHIGNGGSITAVKAGKSVDTSMGFTPLGGIMMGTRTGDIDPAIIPYLMQYTEDFNTPEDISRVLNRESGLLGVSANSSDMRDIEAAVAEGNHEASLAYEMYVDRIQKHIGQYLAVLNGADAIVFTAGVGENAESFRRDVISGISWFGCDVDDEKNVFGVTGDISTEAAKIRVLVIPTDEELVIARDVERLKK
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MPRKACYTPVAKRKSCLSLVVIHNISQTYITTEMERTDSIFQPPTNEKYITVLSIDGGGVRGLIPAVILEFLEAKLQEKDGKDARIADYFDIIAGTSTGGLITAMLTAPNEKRRPLFSAQEIKEFYLQHCPRIFPQDWRYKFRKIIKSIRGPLYDGQCLHDTIREYLPDNIKLGDTLTNVVIPAFDINKLQPVIFSSYEIKEKPYMNFKLSDICIATSAAPTYLPPHYFETEREKKKIESETTDEKKKIEYQTIQEKKKIESETIHEKEKIKFNLIDGGVAANNPVTILSRTMSQEKESIGLYILMPRKACYTPVAKRKSCLSLVVIHNISQTYITTEMERTDSIFQPPTNEKYITVLSIDGGGVRGLIPAVILEFLEAKLQEKDGKDARIADYFDIIAGTSTGGLITAMLTAPNEKRRPLFSAQEIKEFYLQHCPRIFPQDWRYKFRKIIKSIRGPLYDGQCLHDTIREYLPDNIKLGDTLTNVVIPAFDINKLQPVIFSSYEIKEKPYMNFKLSDICIATSAAPTYLPPHYFETEREKKKIESETTDEKKKIEYQTIQEKKKIESETIHEKEKIKFNLIDGGVAANNPTQIAIGVIGKQLPSYQFPEYSRYLVISIGTGDCKMEGDYTTAEAKKWGLFGWWYNANGSKPLVDIFTQASTDMVDFHLSNVFHNHNVQKNYLRIQEDKLERTVFPLDKATKENMDRLIDIGKSLLEKKVSTVNFEDGRMSPAEIKQMLRHSKNLRKNFQTRSIVVNRKIKPILNHPRNKHCVKDASVKNPTK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVTILQYSADVTATTISTYRSELSAQLAQNLGKWSFELKMYKPNPASIGRSEHHNGNIPQGQQEAAAADQEIGGVAALYTLTQAHSKGDMVYVTQGSAVQGQPGVVVSDSFDMVLQNKMKSIWILRQTLRGDGAEYELMGDAYGRVKVRLANVFLQGTFRGLLFQYEYEGDTLDDRQQQHLMEFIQSSGFPSSNLIIGGNGSGLVQTGTQFVEALAQK
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MKRSIGSNSSGNSGSSKKSKKSNQKTLGAAWGAASRPSSSSYRSSPFSDFGSYMEVKNRKLQDQFETEASSGVSGSEELIFQGVSIFVDGFTIPSHQELRGYMLRYGGRFENYFSRRSVTHIICSNLPDSKVKNLRAFSRGLPVVKPSWIVDSISANRLLGWVPYQLDQLNDTQPKLSAFFAPRRHSNPPVTSSQPETGYSEAEEGSSIIAGDSEESRDNVVDEIDGVYTEKTTPEMTAQTRTDKLKSSEVNAETLGNYDKEEKELTSELQPTSNLPSASDNKSSHGKPVAPAAGSSVRRHSTVEDPNFVENYFKNSRLHFIGTWRNRYRKRFHGSFNGLKWTDSGQNTAENANKSTIIHIDLDSFFVSVVIRNRLELQDKPVAVCHSDSPKGTAEISSANYPARAYGVKAGMFVRHAKDLCPQLVIVPYNFEAYEEVADQFYDILHRHCRKVQAVSCDEAFLDVSDLRDVEPEFLASTIRKEILDTTGCSASAGIGGTMLMARLATRVAKPAGQFHISAEKVEEFLDQLAVGTLPGVGSVLKEKLEMQNIQTCRQLRLISKDSLQKDFGVKTGEMLWSYSRGLDLRSVTAVQESKSIGAEVNWGVRFRDQQDVQHFLQCLCKEVSLRLQGCEMIGRTFTLKIKKRKKDAGEPAKYMGCGDCDNFSRSITVPAATDDIEVLQRISKKLFGSFNLDVKEVRGVGLQVSKLEGADPSNKGSSKTLTSWLNSAPASIQTEKDDHVFAAEVREIPADCKRRDTGGVSSLRECNSAEPSVQSGDTNSSLPPMCHLDMEVLENLPPELLTELDGTYGGKLFELIEKKRGKRKINSDSSHVSLDEPHVAHPPFARAPNERAIETNDLMPLSLSQVDVSVLQELPEELRADVLGAFPAHPRQQSSSDAPMETCKKQDKETTYINDGENEIGFSSSSLWFGNPPLWVENFKVSGNSTLEKISEIYCNVAQSRPMLSTVLQRVISEVGSFHDASIKDLEKTVDDVCEFLNEYIKIKVEGDIEEIYLCFRLLKRLAARSQLFHQVYEIVSHFIQALISEHYGGSLSIP
The following text describes a protein:
Function:
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Domain:
Extended rod-like protein with coiled-coil domains.
Sequence:
MEDSAQDAVTAAPSGTPKSKLETLPREDLIKFAKKQMMLLQKAKARCTELDKEVEELKSKPVDGGTDDMIKVLTERLDALLLEKAETEQQCLCLKKENIKMKQEVEDSVTKLEETQKEFEQSHRNYVREMESVKNELIAVHSEHSKEKAALQRDLEGAVHRQAELLEQLKSQSDSEDNVKKLQEEIQNITAAFEEQTSCLQKQLEATSDEKQQEIIHLQKVIEDNAQHYQKDINTFQEEIVQLRATHKEEVNELMSQMETLAKEHEAAVNKLKENRVTLCETSETIPENYQCESESLNEDTSDASQENQKCSVALQEDPFAEHTVYDKVRQLEDSLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQSYVVEKLKYEREDLNRQLCCTVEQHNKEIQRLQEHHQKEISELSETFMSGSEKEKLALMFEIQGLKEQCENLQHEKQEVVLNYESLREMMEILQTELGESAGKISQEFETMKQQQASDVHELQQKLRTAFNEKDALLETINRLQGENEKLLSQELVSELESTMKNLKADNSMYLASLGQKDTLLQELEAKISSLAEEKDDFISKIKTSREEIDDLHQKWEREQKLSVELREAAEQAAQHNSELRQRVSELTGKLDEILREKSQNDQNIMVQMKTMTEDQEALSSKIKSLYEENNRLHSEKVQLSRDLEALQSQQDFAYKEHVAEFEKKLQLMVEERDDLNKLLENEQLQKSFVKTQLYEFLKQMRPSILEDNEEEDVVTVLKAVGESLVTVKEEKHNLVFEYDARVLELERRIKCLQEESVVQCEELRALVRDSEQEKILLRKELDEVTSTKEALQCDILEMKNTNEKTSLENQTLSTRVEELSRSLHSKNEVHNEKDLVIEHENLRLSLEQRESELQDVRAELMLLKDSLEKSPSVKNDQLSLVKELEEKIESLEKESKDKDEKISKIKLVAVRAKKELDSNRKEAQTLRDELESVQSEKDRLSASMKEFIQGAESYKNLLLEYDKQSEQLDVEKERANNFEHHIEDLTKQLRDSTCQYEKLTSDNEDLLARIETLQANARLLEAQILEVQRAKGVVEKELEAEKLQKEQKIKEHVSTTNELEELQLQFQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNSKIEDLEQEMKIQKQKQETLQEEMTSLQSSVQHYEEKNAQIKQLLVKTKKELADAKQAETDHLLLQASLKGELEASQQQVEVYKIQLAEMTSEKHKIHEHLKTSAEQHQRTLSAYQQRVVALQEESRTAKAEQAAVTSEFENYKVRVHNVLKQQKNKSVSQAETEGAKQEREHLEMLIDQLKIKLQDSQNSLQISVSEFQTLQSEHDTLLERHNRMLQETVTKEAELREKLCSAQSENTMLKSEHAQTMCQLTSQNEALRNSFRDQVRHLQDEHRKTVETLQHQLSKVETQLFQLKSEPPTKSPASSHQPSKSLRERRTTDLPLLDMHTVTREEGEGMETTDSESVSSAGTHIQSLEQLLSSPDSKLERLTEASLWHTEFTKEELAEKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSVANLEYLKNVLLRFIFLKPGSERERLLPVIDTMLQLSPEEKGKLATVAQGEEESASRSSGWASYLHSWSGLR
The following text describes a protein:
Function:
Probable sodium channel subunit.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MARKYIDILKKSKMMLFQDVGKSFEDDSPCKEEAPKTQIQHSVRDFCEQTTFHGVNMIFTTSLYWVRFLWVVVSLVCICLCMYSFSHVKDKYDRKEKIVNVELVFESAPFPAITVCNLNPFKNHLARSVPEISETLDAFHQAVVYSNDATMDELSGRGRRSLNDGPSFKYLQYEPVYSDCSCVPGRQECIAQTSAPRTLENACICNYDRHDGSAWPCYSAQTWEKSICPECNDIGFCNVPNTTGSGNIPCYCQLEMGYCVFQPESRVRRIWEFQGNKIPEKGSPLRKEYMEQLTQLGYGNMTDQVAITTQAKEKMILKMSGLHPQRRAALGYGKSELIKMCSFNGQQCNIDTEFKLHIDPSFGNCYTFNANPEKKLASSRAGPSYGLRLMMFVNSSDYLPTTEATGVRIAIHGKEECPFPDTFGYSAPTGVISSFGISLRNINRLPQPYGNCLQKDNPQSRSIYKGYKYEPEGCFRSCYQYRIIAKCGCADPRYPKPWKRSAWCDSTNTTTLNCLTTEGAKLSTKENQKHCKCIQPCQQDQYTTTYSAAKWPSGSIQTSCDNHSKDCNSYLREHAAMIEIYYEQMSYEILRESESYSWFNLMADMGGQAGLFLGASIMSVIEFLFFAVRTLGIACKPRRWRQKTELLRAEELNDAEKGVSTNNN
The following text describes a protein:
Function:
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDTLGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTAKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTKNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTREEYQEKGAAILQSAEGATTNREEQTGHKLQHRLKEECRS
The following text describes a protein:
Function:
Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (By similarity). May be involved in the maintenance of axonal integrity (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm. Cell projection, axon. Note=Delivered to axons with Golgi-derived cytoplasmic vesicles.
Sequence:
MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQHENTQPIYQNSNVPTKPTAAKILGKVGESLGRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADADRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQLYINASG
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MGRRSRGQTHVRCRRCGRHSFNIRKGYCAACGFGRSKRIRSYAWAKG
The following text describes a protein:
Function:
Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
Subcellular Localization:
Cell projection, dendritic spine membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MVVYMLARRMARFLMAVCLVFAALSAGVFGDSFTVLKAPQYITFKEGQWPLSAERIPDLAALTMGFSVEEDLSWPGLQTGSLFQRPRANALIVVRGVGSLPLPQSLASYPVENPVPFTLDSVANTVHTLFAEDTPVVLQLAPSEERLYMVGKANAVFEDLPVTLQQIRGRLSQDNSILNTLPPNSLSRNNEVDLLFLSELQVLHDIAALLLRHKHLAKDHSPDLYSLELSGLEEISRHYGTDSQQLKDATEILATMLQKFADDVFSIYSGNAVVEVATLKSFEAPLVRKTRSILESKQISNPGSPYNLAYKYNFEYAVIFNIVLWMMIVLALAVISISYSLWNMDPGYDSIIYRMTNQKIRLD
The following text describes a protein:
Function:
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.
Sequence:
MDMAQYQPGQRWISDSEAELGLGTILAQDGRLLTVLYPATGDTRQYALRNAPLTRVRFAPGDEVTHFEGWKMTVREVEESEGLLVYHGLTAQNEQRTLPETQLSNFIQFRLASDRLFAGQIDPLPWFSLRYHTLERRSQLLQSSLWGLGGARAQPIAHQLHIAREVADRMAPRVLLADEVGLGKTIEAGLIIHRQLLSGRAGRVLILVPENLQHQWLVEMRRRFNLQVALFDKERFAESDASNPFEDTQLALVALEWLKEDERAQDALFAAGWDLLVVDEAHHLVWHQDQVSAEYALVEQLAEIIPGVLLLTATPEQLGQDSHFARLRLLDPNRFHDLEAFRRESEQYRPVAEAVQELLDHGSLSAGARKAIHGFLGSEGDELLASVEGGDEEARSRLVRELLDRHGTGRVLFRNTRAAVQGFPQRELHAYPLPMPSQYEELPAGEHPDLYPEVNFQQQWEDGDDNNRWWRFDPRVEWLIDTLKMLKQFKVLVICAHAETALDLEDALRLRSGISATVFHEGMSILERDRAAAYFADEEFGAQVLICSEIGSEGRNFQFAHHLVLFDLPAHPDLLEQRIGRLDRIGQRHTIQLHVPHLENSAQQRLFQWYHQALNAFLNTCPTGNALQHEFGPRLLPLLDGGEDKAWDALLAEGRARREALEAELHSGRDRLLELNSGGAGEGEALVEAIEEQDDDFALPIYMERLFDAYGIHSEDHSENALILKPSEKMLDAGFPLGDDEGVTITYDRAQALAREDMQFLTWEHPMVQGGMDLVLSGSMGNTSVALIKNKALKPGTVLLELLFVSEAVAPRALQLGRWLPPQALRCLLDANGNDLAGRVSLETLNDQLESVPRVSANKFVQAQRDVLAKQFDVAEGKIVPRHEERVARAKQQFAAAMDEELARLTALKAVNPSVRDSELDSLRTQREEGLALLDKASLRLEAIRILVAG
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLQAAQPQVPVSEKRAGQKVENEKLSLSVASEPPSVAPVKISQPAQPAPETETKRAVQEEAPIKPTPPPLLILDLNGCLLHREYKPGHPKIIHPRPYLEDLFQYALSPPVDQANHRGGSQERNWEVLIWSSAQPQNVTLMCNAIEVQKRSKVSRTRVPRAQANQLEDISNRLDTLNINQRETELAKKAEPIPRRVLDIWSRSQLDLSSEDYSRKVATTKDLRKVWDSFSWTDPESGEELKWGAHNTVIVDDSPDKLSLQPDNLCMVNEFSGDSSDKALLELIEKLKSLRNEANIPEAIKKLNQKPATTS
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for ARF6 (By similarity). Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1.
Subcellular Localization:
[Isoform 1]: Cell membrane. Cell projection, ruffle. Note=Colocalizes with ACTN1 in membrane ruffles and central reticular structures; [Isoform 2]: Cell membrane. Cell projection. Note=Accumulates in microvilli-like protrusions; [Isoform 3]: Cell membrane. Cell projection, ruffle. Note=Colocalizes with F-actin in membrane ruffles; Cell membrane. Cell projection, ruffle membrane. Cleavage furrow. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane.
Sequence:
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLIRRVVGPGPRGRDLGRVTAPCTPLRAPPSPHIAPSPWGPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPASGGLSRSWDLGGISAPRPTPALGPGCNRKLRLEASTSDPLPAGGGSVLPGSRDPSRGPLVPPQIGADGLYSSLPNGLGGTPEHLAMHFRGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDAPSSGAKPPEQVLPSRGVGSKQGSGVAVGRAAKYSETDLDKVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPHGTAQPPASRPSPCPGPSSSLGSGNEDDEAGGEEDVDDEVFEASEGARPGDHMPHSGLLKSPVPFLLGTSPSADGPDSFSCVFEAILESHRAKGTSYSSLASLEALASPGPTQSPFFTFEMPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRREVEESDAGATLAPRKELPSPSHSEDSFGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRVSGGSGSSSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYQPGKALSEAELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAHLGKKARGKEADEQRQKEAYLEFEKSRYGTYAALLRVKMKAASEELDTIEAALAQAGSTEDGCPPPHSSPSLRPKPTSQPRAQRPGSETRAGAGSTRPKP
The following text describes a protein:
Function:
Myoinhibiting neuropeptide.
Subcellular Localization:
Secreted.
Sequence:
MSFAQFFVACCLAIVLLAVSNTRAAVQGPPLCQSGIVEEMPPHIRKVCQALENSDQLTSALKSYINNEASALVANSDDLLKNYNKRTDVDHVFLRFGKRR
The following text describes a protein:
Function:
Highly selective xylulose-1,5-bisphosphate (XuBP) phosphatase. Also shows activity towards ribulose-1,5-bisphosphate (RuBP) and fructose-1,6-bisphosphate (FBP), but not towards fructose-6-phosphate (F6P) or ribulose-5-phosphate (Ru5P). Degrades xylulose-1,5-bisphosphate, a potent inhibitor of rubisco produced by the rubisco itself.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATVKISLSLASLSPSSSSSSIQSKLSPSFIPNAAPAKAVKLRFNGKSLRAKPMVYRSSRSVGVTCSASSSLTTLPSALLFDCDGVLVDTEKDGHRISFNDTFKERDLNVTWDVDLYGELLKIGGGKERMTAYFNKVGWPEKAPKDEAERKEFIAGLHKQKTELFMVLIEKKLLPLRPGVAKLVDQALTNGVKVAVCSTSNEKAVSAIVSCLLGPERAEKIKIFAGDVVPKKKPDPAIYNLAAETLGVDPSKCVVVEDSAIGLAAAKAAGMTCIVTKSGYTADEDFENADAVFDCIGDPPEERFDLAFCGSLLRKQFVS