lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTTSWSDRLQNAADLPANMDGYALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFDLTVERLVSIGYPQELLNFVYDPTFPTRGLVFDSTYGNMLKVDAYGNILVCVHGFNFMRGPEIREQYPNKFIQRDDTDRFYILNTLFNLPETYLLACLVDFFTNCDRYSSCEMGFKDGDLFMSFRSMFQDVRDAVDWVHYKGSLKEKTVENFPKYVVKDPKLPLLLSRMNEVGKVFLVTNSDYKYTHKIMTYLFDLPHGPKKENSQMLAGRRGCVKPESSHRDWQTYFDLILVDARKPLFFGEGTVLRQVDTNTGKLKIGTYTGPLQHGIVYSGGSSDIVCDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDIHELESPMATRNRCSLEFKDSDFKRHQLTRSISEIKPPNLFPQKPREITHCHDEDDDEEEEEEEEEEEEE
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAEYANLVRRALGQIGGHGGVRGFLLQLFRVNDVKTGTLIGVDKYGNKYYEDRKHYFFGRHRWVIYTTEMNGKRTLWEVDGSMVPAEWHRWLHCMTDDPPTTHPPEPKKFLAEIHQFNVSGTPQQYVPYPTTRKKIHEWVPPKAGAQ
The following text describes a protein:
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence:
VAVAGPVPSSSKALVGCAARSAYSNTVDRRRAGPSPTGGATVPRSAVLRLALTFPKFPPSWLNWSTGIPRHTLRLPSHPGTATPGDPGPKAPASSPHGPGARSKAPADCAAPCPRSPRSRLRSRPSLPRALEDLLGSYPGSGGPRRPGGPRRPGGLRRPGGPRRPGALARRSHGLPGSRTTTALAPSRCPRPPSPPSPHLGPATRLAGPGGQRGSRPGRSASPRPLDVPATRSKISASRKLQLKTLMLQIAKQELEREAEERSGEKARFLGERCVPPDVSGLGTPELQELCRTLHSRVDKVDEERYDLEAKVSKNVTEIADLTQKIFDLRGKFKRPALRRVRISADAMMQALLGARPKESMDLRAHLKQVKKDDAEKENREVGDWRKNIDALSGMEGRKKKFETSGGAQA
The following text describes a protein:
Function:
Component of the 60S subunit of the ribosome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASRRVDVVLMINSPTLLLYGIAPDKQRLIFAGKQLEDERTLADYNIRKECTLHLVLRLNGGGKGGCYPPKVDPNLLQLALKYCQYKMICRECYARNSIRANNCRKKKCGHCNEMRAKKKLAFKQA
The following text describes a protein:
Function:
Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
Sequence:
MGANLNSAYAAGVKIAIVMGSKSDWATMQFAADVLTTLNVPFHVEVVSAHRTPDRLFSFAEQAEANGLHVIIAGAGGAAHLPGMLAAKTLVPVLGVPVQSAALSGVDSLYSIVQMPRGIPVGTLAIGKAGAANAALLAAQILALHDTELAGRLAHWRQSQTDDVLDNPDPREEA
The following text describes a protein:
Function:
Catalyzes the decarboxylation of 2-ketoarginine, leading to the formation of 4-guanidinobutyraldehyde.
Sequence:
MGARALRRERRLRWSPNWTRILPMQPQKTLTAGQALVRLLANYGVDTVFGIPGVHTLELYRGLPGSGIRHVLTRHEQGAGFMADGYARVSGKPGVCFVITGPGVTNVATAIGQAYADSVPLLVISSVNHSASLGKGWGCLHETQDQRAMTAPITAFSALALSPEQLPELIARAYAVFDSERPRPVHISIPLDVLAAPVAHDWSAAVARRPGRGVPCSEALRAAAERLAAARRPMLIAGGGALAAGEALAALSERLAAPLFTSVAGKGLLPPDAPLNAGASLCVAPGWEMIAEADLVLAVGTEMADTDFWRERLPLSGELIRVDIDPRKFNDFYPSAVALRGDARQTLEALLVRLPQEARDSAPAAARVARLRAEIRAAHAPLQALHQAILDRIAAALPADAFVSTDMTQLAYTGNYAFASRAPRSWLHPTGYGTLGYGLPAGIGAKLGAPQRPGLVLVGDGGFLYTAQELATASEELDSPLVVLLWNNDALGQIRDDMLGLDIEPVGVLPRNPDFALLGRAYGCAVRQPQDLDELERDLRAGFGQSGVTLIELRHACAR
The following text describes a protein:
Function:
Essential for appropriate transcription during embryonic development. May act during transcription elongation to activate the RNA polymerase II large subunit (ama-1) by phosphorylating the Ser-2 residues of the C-terminal domain 7-residue repeats. Does not phosphorylate histone H3.
Subcellular Localization:
Nucleus.
Sequence:
MSMLSMDGIVAGGGSSSGGGERSFVLEQKMFNTGPQNKALPTVQSSGSSSNHAPIVGESPLGTVSSTMATGDTGRVGNVTYMSSGMLGATQFMPQNSSHPSTSVMMQQVPPQNGGATRSSPTEMQQCMQAMSEDSIEMRDYNSGVHHMHPHQMQMQQQQQHHQQQYNMSYHNHQQQMQQMHYHQQQQQYQQQQAQHHQMYAPQIQQQQQQPQQQSQQQSAQQPQQSSAALQHVNESSNLSSAGSISDREPEQHGGTPQRPTAPQSSTATDKKTRKRRKAGPTEDQATPKQERKITEFMKVGGEVASGNSVARCLLTEYHQNQGSPKRQPAVQQNGSNSYDSQQQQPQMNQHEMQNSYWGVATPSLGVNNRGTPTPTQQQHYSSDSNSNSNQSPPGQGNQSGRMVRTIDEETQTDSSLSQANPQNADEVAKMNRIIEDHRRQIEELNSKNSLERRKNEASKETIKRLLIDKNQIERKALRDKTAADSPRIGCFKTTRTGDSFRDQWVDGWAFAEMDKKTEQINAERNEIASASALLKKRKPLGIGKEPKRPQAVNSQNDSNGMQPSTSSNTNGDDAIFRRPEEPKEIQYQEYIELDEIYKLRREHLRKEETDLSMEKERLEKEKQHHVRELKRASNESASQFNDHRLLHKRYLMLNLLGKGGFSEVWKAFDIEENRYVACKIHHVNKDWKEEKKANYVKHAMREKDIHKSLDHCRIVKQYDLLTIDNHSFCTVLEYVPGNDLDFYLKQNRSISEKEARSIIMQVVSALVYLNEKSTPIIHYDLKPANILLESGNTSGAIKITDFGLSKIMEGESDDHDLGIELTSQFAGTYWYLPPETFIVPPPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQKILEYNTIINAREVSFPSKPQVSSAAQDFIRRCLQYRKEDRADVFELAKHELFRPRGAIRASVAGSLLLVIITLCQHSNRSEDRLCVSNV
The following text describes a protein:
Function:
Transcription factor that is necessary for cell cycle progression from G1 to S phase.
Subcellular Localization:
Nucleus.
Sequence:
MKSGGRSKEPPVAGEITGKRPKRKCLQWHPLLSKKALDFSEEEEEDDEEELEKPGLCSPNQDPQVQSGSTTEEVEEDSSEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLEPNEKQKYTDMAKEYKDAFMKANPGYKWCPTTSKPVKSPSYQTVGNPRKKVWSFSCNSPKDSTAKKVPKTNSLPQLNFAMADPTKMGGLSMLLLAGEHALTNREIPSKPSLPDIANEGDSFPDEKEEISSQTIPNRVPDITESRVESALSPVAESSLSVAPEGKPCKQSALFQLAEMCLASEAGKMDAVASPPEDSSSTASLQQTAVKPDVKEEGSDPDHYPHMHTSPLCPPSPTSTSTDATPPQQNRHASRVKKKSKKKEAAESNHSEISSSPKQVNKKCNHSEANMDSIFSTIEAVASGAWAPTDDKNKKRMQTCLGNLPKKKCKTKAKAFVKEKEEEMDESSGQLGSPDGDVKERMTDMAPKTEAEEDAAEGVDIQDCMPEPRVSQCNISPAKEEERGKESHSDPAFELNTENRGSRKSERSCKGALYKTLVSEGMLTSLRANIDRGKKGAFRAFDDANWSHESWTMSNIGPNNPKKLKKSKSKDESQSLGKLEEEFEKKFNSLPQFSPVTFDKKGIAVAKKRKSDGSTNQEDTPKAGKDVQAPSSMEMLVGSQKRKARKTKITHLVRTADGSVSAAEEDKTKDLNQEQDKKPLPQQNLCNEKRCYSPRAEEADRSTEPQELPTFFSLAALAEVAAMENAHRVADEGSKHLKLYTDEGYTPCRGQRSLAPSQKKELAQTPVLISCADQ
The following text describes a protein:
Function:
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSSGASASVSQAAAELQQYCMQNACKDALLVGVPAGSNPFREPRSCALL
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
METDQAKHEKEESSMIAQFGIPHSISPRLQNGCHFSEGSPQPTGDNNWITSPVQYNPNKVSNSLKRHRENCIIPASEESLFDQESYKMNGDLMNGELKHGFTGDTLLHQPKRKKVDLEIKRNDGTSSEMVDNLPELTNATNFECSSSQREFSLDKRNHSIQNGDIFGRPRNKQFPNGAVSASSTLESTPGDLLEKTLSQYYPEQVSIAPQTSGSQLDTVNGSLDNQLSSEGAQPPALASGLLPSGQMPNSQQQQPRAPENSERGNSCNSYLVNGFSSSFGADHQQQQQPHAYSALEMRKLSGEITPTNDTNCSQEHPTSIPHFTDQSDPQSAYKNTQQEFDHSPFLRSSNAQHAIDENGRYRCFANSGMAQNEKSGSDQFLHLSTERSQCGIQPQNFQENGRTQNNDDEMGQHQHHIGKGNGLENTGWMEENPSNSTQQQAPPSQTQDQDMWRALPPKPNVERTASPQRDTQIMEPGPVQRFQIQRSLADMSPGSNTSQQKLPELLSNQMQFAPSQQNTATRWQHQSPKAFQMQQTPVTEMSDQQNFPQNQQGNNYFQKDSQHLSDDTDLQDILSAGLLTQQQQHCKLQRPLSHPPQFEEQQLKSPHYRPHSQPPPEQHLPQLSQSLGNNLAQANNSQHSNHATFMYSNKAEMQQQQRQYLPNLKQFQPQLPNNHCHKHNKMDFTQTSTQSQPHLPQGALNQQVRNQMHPKAEPQLKSSCTQFQRGPQLPLGSMGPQTNFQRNAAIRMHLLQKQELQNPLHPLQSSELNQSQRAIKMEPRFELPTSQQQGQLLHMREPDKGGLQVKQENHPSPCNHKKIPRSILASMEQSLRQYQLSTVFEQKSLLIHSSNKVKVESSGPVTILSTNTEVRDVQSSIPAQSTKKGLESTPKKEQLLQSFVDSPMKLLDTPIKNLLDTPLKTQYDIASCHCVDQIVEKDEGPYYTHLGSAPTVPGIREMMEKRSGLTGRAIRIEKVIYTGKEGKSTQGCPIAKWVIRRSSVEEKLLVLVRERTGHRCETACIIVVILVWEGIQASLADRLYLELSETLKKNGAHTQRRCAFNEERTCACQGLNPEESGASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDVREEEKVERNFQNLATLLAPLYKAMAPEAYGNQVEHEHRAPDCRLGLKEGRPFSGVTACMDFCAHAHRDLHNMQGGSTVVCTLTREDNREIGRIPEDEQLHVLPLYKASNTDEFGSEEGQQEKMKSGAIQVLSTFRRQIRMLAEPAKSCRQKKLEAKKAAANKNATLEGSGDKAEKASLAKSKAGTYENTAQSTPMTGPLPGAVGATMQSSHLSQPLGAHPQQQHQSMIPPYSRSTHPGFMRFPNSPGSFPSTSKPGSMCPTQAQAPASPYPSPLNVTNSYMNGPNRPYPDYQRNGMPLDNCHPYYLANQKHLNMYQQQLPALYPEQQYGLHQRFDVNYPPRYSESGLQVNGYNGMRPAQIMQPYNPYGPSRPLDAQFIDPLSRMPSGHGGMDYSPVVSKSNQLGEYPNTYLHQNPHILPSGLDPLHTQVKTEMGIPDPQMLSAQLRGRCLNPDTQSELSLPNGGVMGSNIKQEPGTPKTPTTPQKPEVWSDNEHNFLDPEIGGVAVAPSHGSVLIECAKRELHATTPLKNPDRNHPTRISLVFYQHKNLNEAKHGLALWEAKMAEKAREKEEEAERNGGEGTPTKGNKKGVKREHPESETTGEPPYKRFIKALMEGSLSSTTNTYVNTSPYAFTKVTGPYSRFA
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Sequence:
MVRNASATWSSSETEILVDELIARKDVIFGAQSSTVTNKIKQQHWDEIVATINQQFPSQHPRDREETKKKWNNLSSDARKNLKEHKNSVEQTGKGKAFPMKPLNEKIVNMIWGESSAALPGNSISGGVETDVMENANDTLLINNSAASASLHTMNASSCTFLAKTVQSSFLVNEEDDLSAFEFDDSQSNQSSLCQTFSNADFADGVPSTSRVVALLPKRTSTPVLSTKTTDHSSANIVFAKRSQATLAPVEKYAPLVAVTSSSTTNGESLNKNPLALRDIVAQFAPKEHMLKNQTFLFLRG
The following text describes a protein:
Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPL12, and of UBE2E3 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLNSASSVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEKSTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLVESVKVQDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNFACSLWNHHTDTFLQHVSSGNEAAVLSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLHGIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKVLLDFLDQHPISFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLEGPTNVEDMNALLIKDAVYNAVGLAAFELFDSVDFDQWFKTQLLPELQVSHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNVQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCVTPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQTYAAGLCQSFYELLPEITTEGQVQVLKVVENALKVNPVLGPQMFQRILPCVFRGVIEGERYPVVMSIYLAVMGRVLLQNTSFFSSLLNEMGHEFNQEMDQLLGNVIEMWVDRMDNITQPERKKLSALALLSLLPSDNSVIQDKFCGIINISVEALHDVMTEDPETRTYKDCMLMSQHEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEILGEQGFQSLMETVDTEIVTQLQEFLQGF
The following text describes a protein:
Function:
Structural subunit of tRNA-specific adenosine deaminase, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A. The wobble inosine tRNA modification is essential for cell cycle progression in the G1/S and G2/M transitions in fission yeast.
Sequence:
MAGDSVKSAIIGIAGGPFSGKTQLCEQLLERLKSSAPSTFSKLIHLTSFLYPNSVDRYALSSYDIEAFKKVLSLISQGAEKICLPDGSCIKLPVDQNRIILIEGYYLLLPELLPYYTSKIFVYEDADTRLERCVLQRVKAEKGDLTKVLNDFVTLSKPAYDSSIHPTRENADIILPQKENIDTALLFVSQHLQDILAEMNKTSSSNTVKYDTQHETYMKLAHEMARTSLSNREVPVSCVFVYKGEVIGRGFNETNCSLSGIRHAELIAIEKILEHYPASVFKETTLYVTVEPCLMCAAALKQLHIKAVYFGCGNDRFGGCGSVFSINKDQSIDPSYPVYPGLFYSEAVMLMREFYVQENVKAPVPQSKKQRVLKREVKSLDLSRFK
The following text describes a protein:
Function:
Nuclear lamina-associated inner nuclear membrane protein that is involved in cell division, nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis. In interphase cells, plays a role in anchoring and spatial arrangement of chromosome arms at the nuclear periphery, forming so-called lem-2 subdomains. Both arms of autosomes but only the left arm of the X chromosome are anchored in lem-2 subdomains; sequences bound by lem-2 are mainly repetitive chromosome sequences and inactive genes. Involved in chromosome segregation and cell division, probably via its interaction with the nuclear intermediate filament protein lmn-1, the main component of nuclear lamina. Required to organize the distribution of lmn-1, nuclear pore complexes (NPCs) and chromatin in mitotically active cells. Involved in the nuclear positioning and efficient anchoring of microtubule-organizing centers (MTOCs) to the nuclear envelope during mitosis as well as on maintaining correct nuclear morphology. Contributes to closure of nuclear envelope (NE) holes and prevents excess nuclear membranes after meiosis and mitosis. Together with emr-1, plays a role in baf-1 enrichment at the nuclear envelope in anaphase. Together with emr-1, involved in muscle cell attachment to hypodermal cells, as well as muscle cell location and sarcomere organization. May play a role in radiation-induced DNA damage repair response.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side. Nucleus envelope. Chromosome. Note=Remains in the nuclear envelope until mid-late anaphase and reassociates with the chromatin periphery at telophase. Recruited to the reforming nuclear envelope initially at the apical surfaces of chromatin, from where it spreads to the lateral surfaces facing the spindle microtubules. Requires mel-28 for chromatin reassociation after mitosis and for nuclear envelope localization. Localizes to the nuclear envelope at non-core regions after mitosis. In meiosis at anaphase II, appears on the chromatin surface farthest from the extruding polar body. After anaphase II, forms a plaque on the oocyte-derived pronucleus adjacent to the meiotic spindle. Later disperses into a uniform rim around the oocyte-derived pronucleus.
Sequence:
MVDVEKMSDAELRAELNVRGANVGPVTGTTRSLYEKKLKKLLSGGAKTPARPTVAKPAPKPTPKSAPAPKSPKSPPARRSIPRAAATAANSTINSTFNRSEIEEMSDSDDDMRDDDDDDEEILSPKSKQSSFRSANSTASSVGRGRPVSSTPNKRLSPVYKPSPVPKNTPRTTSSSSKTTINTTTTRIPSTPRRITSVPGLITDFTPSFSTFGSDRPGATPPRKSIYTSKVSKVLHDLGNTTGEEDDDDEFEGQETSRIIYKTEEPSRRGIVKNAWNKVLGYGFDASKNPGDSYDLRAGASRIRVQKNPRTGKVTVKQTNIFNEAIYFALYVILILFVVLGIAYALTTTHRPKTADFSGYWGVLKAAGRDSLNFFYNYAILPVVSLGIFVVLGAGIYFGHRKYKEAKEQEEAKLYELIERITELIRESSIDGDPYVSQPHVRDVLFPPAKRRSAELARWEQAVKFIDTNESRVATDVLVLPSGNECAVWKWIGNQSQKRW
The following text describes a protein:
Function:
Strongly inhibits ADP-induced platelet aggregation on human platelet-rich plasma. Also avidly binds to the laminin-binding beta-1 integrins (alpha-3/beta-1, alpha-6/beta-1, and alpha-7/beta-1) in an RGD-independent manner.
Miscellaneous:
MISCELLANEOUS: Negative results: does not interact with the collagen-binding alpha-1/beta-1 (ITGA1/ITGB1) and alpha-2/beta-1 (ITGA2/ITGB1) integrins.
Subcellular Localization:
Secreted.
Sequence:
MIQVLLVTICLAVFPYQGSSIILESGNVNDYEIVYPKKVTVLPTGAMNSGNPCCDPVTCKPRRGEHCVSGPCCRNCKFLNAGTICNRARGDDMNDYCTGISSDCPRNPYKD
The following text describes a protein:
Function:
Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQFVSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFILVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMIVIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLVSLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKERITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWISIWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGTQIEITVPIQGEMQDE
The following text describes a protein:
Function:
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLAKALDIRIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLVAACIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWLAELAEERRTCVFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVVRGSLDELAIWAAGGVLGEITVVVAGAAPHAELSSLIAQVEEFVAAGIRVKDACSEVAAAHPGVRTRQLYDAVLQSRRETGGPAQP
The following text describes a protein:
Function:
Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Subcellular Localization:
Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)).
Sequence:
MVSSAAMARSNGDKPSTSSMEEDLEIEQSMRNASIIDHQYEKEENKNHRVLNAFDPADKTTFSDMIHVDVPDTKTLVERSDGITKYTAYNIHINGWYHGSVRFSHLYEFAELIKQKFSQRYKGPEFPAKKLFKLDPKAIDERRQKITKYFQALVQHPEVARHYLVEKKLLGFQIDSFRATSQYVTLDVFLGNGEKTTIKCLVSDSTLEIMKIICEKLGFKNKDQFIYHFGLFMAKGRDPTNACYSVTTENFNPLLTRFLRNFEAPFVSLSTANQKYNENGHYHFLCLRKLIWDSRVEEPLLDDGNFVELLYKQAMQDYKNGHMDPVKEDLDSKLKSCMARNDSKMFLRTCHQLSTYSYEIMSPCSCDYPKPGTPCEIKFGRRQIIMTTRDETGKPKPSIFRATRIRVWRITQVMDKISFQFEYLMAKDTFEWITLDTDQSILMSLLLQSIGSEILYEHNNMTIEQQVMKEKHSKGNYVEKSEKLPRDPKKPIIVLKNEVEDTDPLGVMEHYHNYNRMLTTISDGIPQRNQAFTDITNDDL
The following text describes a protein:
Function:
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVVLTNLPPPTEGVRHTEKNTVAVVGEKNLGDGTLYIAESCVAWTNPGGEGFNLQYPSISLHAVSRDQTAFPQQCLYIMLDSDITDKEPSPADTGSGDEEEEEENQADMTEVRFIPQDNTALDPMFQAMSGCQMLHPDPEDLDSDEEEYEEDGCGDAEYFEDAEGFEHLTEEGRATLAHLESVIQVPGVGNGQAGEFSQTMGGVHGELNGRDDDDTTQPTEPMEVGQFDDADPEK
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.
Sequence:
MEHVKSETKELVHKLVRLSITENEEEISALLKNLRLLLTKGRENQETLAESAEFSSFLNAVAFSPVMRTEHRLIHNLSLQVLANSVVNNETTQALIWSQHGLKIAEQAYASPLGSSNNVLLMIMYNIYISGHGLITDLVALKTCLQLWRALNEAQCTYNFEYLHFFLEHFIVQNGRACVACYQKLETEDRVAFLDYVAHYLRENSPNGDVTLFLLQHFAKEFRMKSDCLLRETIKLKHELHPREVHTLLRIIASASGSEKYANVYPNDQSLFINVSSLLRCIVSAGKEPDGGGLDKPMTKLEEVALTSDIDAGYEKKVSYELKTLLVRCSANLLYDNKANKGYCLDTQLLPTLLECTTMDARNPLMREWSILAIRNACINCPEAQQVIAGLTMQGSAPNDILTELNLDMGALRISDRQ
The following text describes a protein:
Function:
Involved in O antigen modification. Catalyzes the transfer of the glucose residue from UDP-glucose to a lipid carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKISLVVPVFNEEATIPIFYKTVREFEELKPYEVEIVFINDGSKDATESIINKIAASDPLVIPLSFTRNFGKEPALFAGLDHATGDAVIPIDVDLQDPIEVIPHLIEKWQAGADMVLAKRSDRSTDGRMKRKTAEWFYKLHNKISNPKIEENVGDFRLMSREVVENIKQMPERNLFMKGVLSWVGGKTDVVEYARAERVAGDSKFNGWKLWNLALEGITSFSTFPLRIWTYIGLFIAGMSFLYGAWMIIDKLIFGNNVPGYPSLLVSVLFLGGVQLIGIGILGEYIGRIYIETKKRPKYIIKNEKKNG
The following text describes a protein:
Function:
Component of the transport system for branched-chain amino acids.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MSHRLSSKDIMALGFMTFALFVGAGNIIFPPMVGLQSGEHVWWAALGFLITAVGLPVITVIALARVGGGIDALSTPIGRSAGLVLATVCYLAVGPLFAIPRTATVSFEVGIAPLTGNGPLPLFIYSVVYFALVIGISLYPGRLLDTVGHILAPLKILALAILGIAALIWPAGPLITATDAYQQAPFSSGFVNGYLTMDTLGALVFGIVIVNAARSRGVVSAVLLTRYTIWAGLIAGIGLTLVYLSLFKLGSSSGSLVPDAQNGAVILHAYVQHTFGGLGSMFLAALIFIACMVTAVGLTCACAEFFAQYLRLSYRTLVFILGIFSMLVSNLGLSHLIQISIPVLTAIYPPCIVLVLMSFTLRWWQHASRIVAPVMLISLVFGILDAVKASTFANFLPAWAHHLPLAEQGLAWLPPSLLVFVVIGLYDRIFCRQKIVVKQ
The following text describes a protein:
Function:
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
Subcellular Localization:
Nucleus.
Sequence:
MGRSKSHNKAYITMSEWVSDFGGKTAKEKRSSFKPLPFYCCSLSLQHLEEPVSNENGNLFDLENITQFLKKHGKDPITGNPATIKDYFPINFYKNENDEYHCPILEKVFTDFSHIVAIKTTGNVYSYDSVQKLNIEAKNWIDLLTDKPFNKSDIVTIQDPVNRSSKNTMGNFHFVKEGIEFEKGEVESNVNVNDATSRIFKQMQEKGIPLSEKDSEVKLKQKIQEKEEESKKLMTEEEKKQKMFEQFKKDKAEKEESLKKRAVQAPSFTSTGYTKTRLDEEHPSLTPGKTTKKKGYVQLKTNLGDLNLLLHCDLVPKACENFLEHCESKYYDNLIFHRLIKNFMIQGGDPTGTGRGGESIWGKPFKDEFKPNLLHNERGILSMANSGTNTNNSQFFITFRECPHLNNKHTVFGKVVGGMEVLKTIELVKTNEQDKPNHNIKILGTKVIQNPFRTLDEEQFEEKLKQEKKNREKLQKSEVLDEQVEGNQKGLWYSNPTPELKANNDKTVGKYLNNSASSPSSSLGKRLNELPPKNNPLKETLIKQQEQQKKVKTSSYGNFSNW
The following text describes a protein:
Function:
Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MESSPDLDPNKDDLPLCANTNHMLVRHYVLDLAVYIQRKVIAGSIVLFLEPGLGSSKQCESGCASNTQDQSQVSTKHDINSPITPEHKRLIPPEEPPYLIGGMDVGSEDESEEFTLVLDCCDLVVSRVEELDVTTVLDLKKLDVNEQDVYAGLVQRLVSMPSSCWRTQHELYLQCSRSSNIVNTQPLQFHMDRWSLQIRKKGVRTPHDFPCAVRIWYETKPTGGSVRWTKDQDGRCCVYTMGSPINNRALFPCQEPPVAMSTWQACVRAPCDFTVLMSGENQAFPEPAETGFQQWDYYVTMPMPASTFTIAVGQWLEAEVKVTNYVDDKLSLPLDSGDEEYICSHMDYPCRFMVGPARVQTVIPHRVFAPSCHLQKAQDMVLPLLPLCLTAAHSVLGVHPFPRLDVLIVPSGFSSLGMASPHIVFLSQSVLTGERNLCGARLCHEIAHSWFGLAIGARDWTEEWISEGFATYLEDVFWSHVQKLGCREAEEQRQLKALLRWRRLSDELQNSEEELQVLRPNKENTGEVSESGASVVKHALNPEKPFMQVHYLKGYFLLKFLADQIGEEKFLQFFKVFVGKFHGQLILSQDFLQMLLDAFPAMSSQGIALETIFSDWLDTPEMPEWLRDECSEWLRTPAVQEVKGEVAKWIHFSGSGGKGSKRKRAGPKVNFKELNPEQLVLLLEFLLEECNLSASTLRLLQSTYNLQAQDAEVKHRWCELAVKHKHTAAYRDVELFLIHDQAMGVYLYGELMVQEDARQQALARRCLSIIKDDMDQSARTVVEEMIL
The following text describes a protein:
Function:
Required for assembly of cytochrome c oxidase (complex IV).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MGYKPFQSTYYDERMRASPALLRARAPYLVKNTITGFAICSLVIGIYTYTINAISQDEFEDVIVPEEPMRRPQQLSGGNVPGATTQAIVDARK