lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MQGAMEGGVVRIGDQIILEEDYDETYVPSEQEVWDFARDIGIEPEKEPELMWLAREGIVAPLPPQWKPCQDVTGDIYYFNFNNGQSMWDHPCDDHYRELVAQERKKLLARGNLKKKEKKKKDKKDKKDKKDKQSLKQHAPSGTLLAPVQVPLGNLAPLRGPVASPAGIQRGSLHSDMGSSVDSGLVDRGEAQSLHRTAGLFKNLHMDVSALGCSFESEDNSKAEEENHGGHLADVTEAHLQDQRSPTEEAGSLREKESLKSRHAEGESSLDSGDACPPTPVKALSGVAHSSLSDQNKEESDEKLAGNEGLGEKAAEVQGDVSAADELPQSLEEGRAAGTDVPSSPGQPRAASPDAEAAEADQLASLAVTVDTVSVDENIVNEMREEAADVKADSRLDAGKLSKVSESSECMEDLQASNRLDQELIQHVDLAFQSQFSERVLDVDALSPALDKSPCKAQELGEEEKDQSKASVDEEQSKRTKAAESERDQSGCEASEQKCVALENANGEEAVALQLEEELPDSLIDLEELAALQKVQPEKEIKQEQSLTQSSEESLEGIAKELEKEVEQEKMHLLQAKKEKIQQFQEEMRLQEEEETQKLYQQKEKSLRTLKEDLAKVCEEEELRVRKEEAERLSKLRATITSETEAEKEKIRAEQELALQKLREEWESLQVMEKGSMERKKQLALEKMKLEMEEAQQKETIRLKKEKEQFLRELKERLEMEKKKAAEELEKQFATELQQLKSAAEEKHRKVTSSLQTQIAEAQRSEEAWLREDLQRAEEKVQQKAYRLAEYERELSELMSEKRHEVEKDHERKMARMKEEHQEVLARIQDQYEEEERKQRAELFEGLRGELALLRQRHEVEVKALQAELDERLTALQHRHGEKERRLQDSENELEIRAKNIKARSVQLLSQEESLRRKKQQLLDEDRRTERERDEAALASQLRLEENRKEHSDLLESIWQLRKALEELQDQKAELEAQVDLLQTRSQRLQKRISELEAAVRSKQEILKELEAEESAESPRRKAELHVEDLRETIQAHSSREPASPPSQSHEDSNFQFDQVRSYISAEGVSIRKAKEFLVRQTHSMRKRHTALKAAKQQWHQDVQKAQEVVQDPNNSQLLEGMRKNLEEEAKQLDKMKSAMRKGQVLLKKKEEKLSQLESSLLEELSDEDTLKSVACKKMVTFDLSSSENTNSISSVNIHLPKSDLRTEVQIALQQDKIQYLTNSVQHITDELNGVLGVLSSLNALQPPLFTSTQVPCDGIPLSTYANLAGLQAGASSRSSAGMSVPDQWAWGTGLSSSRSFLAGQSVDRFLAEKWHKYFPGGFPSCSGSSGPSDNKLGYVPAGEQMRMFQGRESDKMSIQGMIETNKKWLEDFKSDSRVPLFPGAQKPPASSSSLLQLGLDENRQIKVYRY
The following text describes a protein:
Function:
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Sequence:
MRFSFFSGIRDLFRHLIISATSGALSDRLGWLWAVIARVFSGSVWLRHKIAKSPHQVQATVVSVGNIVVGGTGKTPLVLWLAQALHERGLSCAVLSRGYKGKYSKKKAFTIVNPALHTASCVGDEPLLLAKYLPSGTVRIQKDRKTLAEKSAGDFDVLLLDDGFQYNRLHKDVEIVLVNGSDPFGGGSFFPKGRLRDFPERLAKADYVMINGRCSPSDQRELDRLHPEEKIVIEPQISEIVWLNQSVNMPRDHWEGLGVGVFCGLGFPKGFLAMLRDAGIHVLGTYLLPDHVGITKQELELFCKKIILRQGVGILCTEKDSVKIGALAEEISFPVGEVRMRFSCVCNERRMVAMLDAIEAIQKNKRVTT
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MQIYLGITICLVAFLTVIDCAIPYYRTHSNFGSLGRRKVRQVQRDLTYRWPNNTVPYYVGNVTSTIKKSVRLAIEELQAWTCIRFQNVNEKYSDGDSVRIVDLGSCSSPIGRQQIGTQDVSLTKNCWGMGTAIHELMHAIGIEHTQSRSDRNRYLDILAQNIDNRDLPNFELLSPRLWANLVPYDYGSVMHYSADSFSNKDDEQTMLPKDRSFIETMGSMIPNFYDFDQINQYYQCYDSCRNAGQLANCANGGIPNPNNCQVCNCPMGYGGDLCDQRPEGCGSTLVATDRWQKQKLSVRFSRNDDQYFTFCNSWIVGPSDRTLQVIYEITSDSIRRQICSFGCYEGGIEVKHLQDPRITNDRDCCLNTPLNLTTTVNPLPVILYTSGATVTYDFSYRYV
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGSSQSVSAGSSGSSSYQSGVPEEESLPNHEYSHPSQDYDFDHEHSHPTQDSDFNHEDSHLSQDYDLAFDLQLAEVMEASRAEEVFAAWEIENLEERIHAVLLAKVLERQQEEEQRMRRETCRICTEDRLSLQEMMTVQPCEHRFCIQCMRHNAEVRVKEGAVEVRCPSENCLAVLDYEACTELLSKGSIQLLEKNRVEQSIPAEFKIYCPYKECSEVMDKRLLDAAVPSSSSSSSSPKSCSKSSKKSSSSSPKSCSKSSKKSSSSSWGASSPSASLPAWTSSAPVPSSSDSLPSSSATSTTQSNARASFMVKCLACGNDFCLKCKVPWHFGMSCPEFEKVPAVLRDFDGVKLYKLASRNKWKQCSQCGSMIELTRGCNHVVCRCKYEFCYLCNRKWTSDHAAASKCPFWDEKKLLDPKKSM
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MADLNSWAMDSLSGLNDVRKDTPMEDFEDLDVLEEELSHVNPPANDLEGFEDDAPRASSPIVIDDFEPTQMQIDPTANFDPPELKYVKEEPIVERVDCGGKKRMTEQEEEEEARWAVAKMFFDHRSLVENQLQSFNQFLGKEMQQMFKEALPVEVVPDHSPASVRISGLPRYARFWYGAVTVGTPDTFTDDEKKVTKVLYPREARLRNMTYSAPINLEINLEIYQTHVKSNQQEKVVLQTMSEDVCIGRIPIMVKSKYCNLSGLADTKLKRKEECAFDIGGYFIIKGSEKVLIAQEERCDQRVYVQYFKKKNTWLATCAPSHKGFFNYRSKSPVRLVTDKNMSTLDMTLPRVSVPIPAVIIMRALGFCSDKEFMEMVCYDLSDLHLMELIRPSILAADEYMVKFLKSKNSTSKTAMQAVRQQDNALAYIGSKMTNNVKPDEECGRDVLNLMFHHIGQGYKQKAYFLGYMIRQICLARLGRCPEDDKEHYKNKRLDLAGQLLRHQFRAAMAHLQRDMQKQLQKHLGKEDSLGSIKTFVQESIITKNLQGAFTLGNWNTSEGQRSSGVVGDIKRTNTIAMISHLRQLRLNLPPKSRPTESARHPNFSYWARVCPVQTTDGDDCGLVKNISLTGILSSNTEEEPLMAILLDHGMRYLEEILPSSLADTDKVFLNGKWVGTLDNSQDLVNILRAHRRKGAVHEETEVVKDDHLKEVRIYTDGGRILRPLLVVQNQCLVLSKRHLKKINMDMKTGKTAKECWQALLADGVVEYLGVEEEEGAMVALGSDDLAKARGCDGALVYSHCEIDSSYLMGLGASTIPFLEHNQASRNLFQSDKHCKQAIGLYTTNFQSRADASASHLFYPQKPLVTTRAASILQKPELYSGQTVIVAILCYGYNQEDSIVMNQASVDRGLFRSAHYKTYKGEEKKNIQEQFSKPSTSDVKGWYNKSLDKVEGDGFPCLGEKLVKGDIVIGKVTSEVHNPRQVDSSTHLKVHQKGHVDQVMLSSEEDGHRIAKVRLRVTRAPQAGDKFSSMHGQKGVIGALFPQEDLPFTQQGIVPDIIMNPHALPSRQTVGQILECLLGKAIAASGKRRYAIPFSGIDNAEAINQYLHEAKLARGGCEFMSNGTTGQRLKVLVTIGPTFYQRLEHMAEDKIKYRGNTGPVNLLTRQPVKDRNSLGGLKFGEMERDCMLGHGASATLRERYFLLSDPYKMYICQSCRRPATMDSSRIPKCQFCKNGKRIVQVQIPYACKLLWQELLSMGICVYMDTKKC
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASAGKWEVVGKGGKKRQHNDKKKEKFSSADAPKLDVASPVPEAETIYQAFDIHDKKQQNKNNHFDPYAEASNDNESQKNQEPKKTVIKRKAPPPKPPKPEQQQLEEALQKVELDQLRNVLAKDQEAFPNNPSLWLKDLASYIHLHLQNVPERDPVFEDKPKDYPMCLLKKDVKGVLMNALKKSSETTLEIFFQYCMNEMVQEMSRGHSVYGLQLMIQCAVCSSPTLTVSKVDEYEDMLIGRKSRPKEALAIMWALGQLPNNNPTQGMAVWLRVMMPVLSTKQLAKYAISYLEDTLSLCDTRSLPRVLAAQDFLAIMHITFASNSPLTGNHSKRRPIKHNKALKSPPPNGVEHEKDPRDGSKSLQRKMLSMYPKLKAMTFASDPASCGQAYFLHLLALLGGEDLTVEHLTEVLDCLTYCLEKDAASFSLWVEHYPTTLNESSVLLYHIIDTWNTRANKVNKEKVHQAVTSFQVFNSLETSKGKQLPGLENCITACRVVEEKSQQSSCFSVRCLLKLLMLLLIAAVSYDVCRHGGYQGSKTARFAQEYGIEQGTIKAYGHVKHAFDKGNSWVQENYPTYYSKFREYADPAGQYAMDKLTLAGQFIEEQSRPARAYLNKKVPELLERVEKEAPVYWAIVHSHVMHWWNVVWPPTRYYLMIVWAFLHEHVPPLIANIQALVLDLAHKIYLLAPDFFNSVAASLESLGQKIVERFPDVVAVVQEYAVIASNLVMNLVNNVIAWLQSAAASNEDIPVTNQKPFPK
The following text describes a protein:
Function:
High-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNPAELNQYQPVATFEKLETSHFCKMEKGSPSRQFMAGIIVNLASVMVGTSLGWTSPVGPKFASKDTTPLDTIPTASESSWIASLVAMGALIAPFIAGPLAERIGRKFTLLGSSIFFLVSFILLLTTETVVQVLIARFIQGLGVGFVMTVQTMYIGEIASNEYRGALGSLMQLCIVTGILYVYSIGPYVSYHALQWACIVLPIAFDATFFFMPETPAYYISKGDKEKAVESLCFLRGKTVDGVQEELHEISTTVEESLRNKGSVMDLFRNAGNVKALIICAGLISFQQLSGINVILFYSQNIFESTGSSLSPAVSTILVGAVQVLASGATPLIVDRLGRKPILLTSAGGMCISLGTMGLYFFLKHTESPSVDSLGWLPIMSLIVFVTVYCIGFGPLPWAVLGEMFPANVKSIASSIVASTCWVLGFIILQFFADLDKAVGSHWSFWIFGILCAVAFVFTFTTLMETKGLSLQEIQDRLNGKV
The following text describes a protein:
Function:
Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. Plays a role during anterior segment eye development (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MEGIKYIASLVFFFVFLEASKTEPVKHSETYCMFQDKKYRVGEKWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPTLHCLSPVHIPHLCCPRCPDSLPPMNSKVTSKSCEYNGTTYQHGELFIAEGLFQNRQPNQCSQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDADIFRQPANREARHSYLRSPYDPPPSRQAGGLPRFAGSRSHRGAVIDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKLDGKCCKVCPEEPPSQNFDSKGSFCGEETMPVYEAVLVEDGETARKVALETEKPPQVEVHVWTIRKGILQHFHIEKISKEMFGGLHHFKLVTRTTMNQWKIFAEGEAQLSQMCSSRVCRTELEDLVQVLYLERPEKDHC
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSDLTPIKLPSSAPFPVVISSVLCKPGDTISKHKTIFKYKYWDYQDDPTSKEDPPKKIRVERLGTFESPIEGEIDQINIKPLQEVMHSDVDLLFVKEACPHTVQYSGLCALCGKSLEEEKDYSGYNYEDRATIEMSHDNTGLKISFDEAAKIEHNTTDRLIDERKLILVVDLDQTVIHATVDPTVGEWQSDPANPNYAAVKDVKTFCLEEEAIVPPGWTGPKLAPTKCTYYVKLRPGLSEFLEKMAEKYEMHIYTMATRNYALSIAKIIDPDGKYFGDRILSRDESGSLTHKNLKRLFPVDQSMVVIIDDRGDVWQWESNLIKVVPYDFFVGIGDINSSFLPKKNGQLTGPTKKRKSIAKLEAAAELAKESDTNNDKQETESGEEEGEEDADGHSDVSNSPVERILELGGGEGNTSLLLEQSLTRNQSIEEQQQKRPLAKLQHDLEQMHEHRHDSDSKSESGSDDESDEEDNLLFDDDNELAALDKVLGNIHQGYYNLFDKDKINKPDLTEIIPSMKSKTLEGITVLFSGIIPLGINLDSADIVIWCRQFGVKVVNEVYPEVTHVVCRDVSEGAGPTFKTRVARKLYPDTIKIVNPDWLFACLSNWTKVDEKDYLISTDDTKLWTVKENEITKYQKALEDRSALANATHIDSIESFDEYDLDEANQEVDDFLAGLSDDDEEEEEEEEDEEIENPESNNDDEEIYEQSTNGHDSFIKDAYSKKRNRDEEEVQLVKKQKIENGENGENENENDLDDLEKELLDGFDDLEE
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Domain:
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MDVNIFHFLFTKTNPGENFSCPKCKILIYDFDKVSEVYQCKNGSWACKNCWIEIFRTTKECPTKECRVESIDSLSRSRFIENGFAGKNMDCPNSLVRSNPNHYEGINVLLDDDGCRDVVTVGNLSSHLKGCIYAFTKCPNDVNGCTGEFRLKNLDQHLQTCGFQLEDCPNCNNKIIRKSIEEHIDEECLKTKIKCLECGSTVERGDMDFHLDNVCPNIVIPCILCDNGCDLLFKRSELSNHLQSIEHISNLNNKIDELNETLNDLQISELNQKVEQLETLLTQARDDPLAQREINRLISKQEKFKSVWDIKNFSKRQFQKGFYFSSPVITVGHHSFHLWLYPNGETSPSNSLSLYLVLTKGEKTFVNFSISIKNHNGNDLNSTFENDKCLEVGGTRWGWAFEKDFKTGGYLKNDTLSIQFTVAIKKQPLITDILSVQ
The following text describes a protein:
Function:
AcnR negatively controls the expression of the aconitase gene acn.
Sequence:
MSVATGDKPVNSRQEILEGARRCFAEHGYEGATVRRLEEATGKSRGAIFHHFGDKEKLFLALAREDAARMAETVSENGLVEVMRGMLEDPERYDWLSIRLEISKQLRTDPEFRAKWTDHQSVLDEAVRVRLARNADKGRMRTDVPIEVLHLYLETVMDGFISRLATGASTEGLSEVLDLVETSVRRPD
The following text describes a protein:
Function:
Involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the transamination to the aldehyde group of 3-acetyloctanal, resulting in an aminoketone, which spontaneously cyclizes to yield the dihydro form of MAP (H2MAP).
Sequence:
MKFGFIAHPTSVGLKRYVKMIDLLQRNSTELHSGYKRDLWRRENLVPFMNFAKITSATGATCEGVIKYMPLVADEMLADARGIANRVVSGIEELVEDGAELVGLGGFTSIVGRRGEATAEKSPVPVTSGNSLTTYAGYKALMQIQSWLDIQPEQEPVAIVGYPGSICLALSRLLLAQGFSLHLLHRAGHKDEDELLSHLPEQYRSRVTLTSDPEDLYPRCKLFVAATSAGGVIDPYKLQPGSVFIDVALPRDINSDTRPDRDDILIIDGGCVTATDAVKLGGESLNVTIKQQLNGCMAETIVLALENRRENFSLGRYLALDNVLEIGELAEKHGFLVYPLASYGERIDRQRVINLKRYYHHDIYSDEPDTEQPPASQLAFIDAIIAQDPAREDTLDRYHQFINPMMVEFLKLQHCDNVFRRASGTQLFTADGEAFLDMVAGYGCINLGHNPQPIIDALKAYLDAQGPNFIQYISIPEQAAKLAEVLCHFAPGNMGRVFFSNSGTEAVEAAMKLAKASTGKAGIAYLKNSYHGKTLGALSITGREKHRRHFKPLLASMIEVPFADIEALRQTLSRDDIGALMIEPIQGEGGVHVPPPGYLRTVQEICRQTDTLLMVDEVQTGLGRTGKLFACEWEGIEPDVLMLSKSLSGGVMPIGATLCRAIFGNGPYGTADRFLMHSSTFGGGNIAAVVALSALREILAQDLVGNAERLGTYFKQALTDVAARYPFVAEIAGRGLMLGIQFDQTFAGAVGASAREFATRLPGDWHTTWKFLPDPVQAHLKAAMERMEQSLGEMFCMKFVTKLCQDHNILTFITANSSTVIRIQPPLTISKAEIDRFVSAFATVCDELSTFLE
The following text describes a protein:
Function:
[Myelin regulatory factor homolog 2]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation; [Myelin regulatory factor homolog 2, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage; [Myelin regulatory factor homolog 2, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABAergic motor neurons synaptic rewiring. Acts in complex with myrf-1 paralog.
Subcellular Localization:
[Myelin regulatory factor homolog 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus. Apical cell membrane; Single-pass membrane protein. Note=In early L1 larvae, localizes to the cell membrane, but then localizes to the nucleus in late L1 larvae. Cell membrane localization is promoted by pan-1; [Myelin regulatory factor homolog 2, N-terminal]: Nucleus. Cytoplasm. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage; [Myelin regulatory factor homolog 2, C-terminal]: Endoplasmic reticulum membrane; Single-pass membrane protein.
Domain:
Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecular Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components.
Sequence:
MGDLNPAETPEPKKNPVAKIASNLYSTQIVKPVPSVSNSTNLSPCQNPNMTNLFYITLLQNKLNKYTQQLLKKNEEGLNDPLANVEQFNIIQFLQNDVDFNLPIEAFEQGNMDQNIRIDPILQRQQMANQPMLMPQHMLQQLHQQQIYEQQLASMPMTPAITDLTRHGSSSSPSTTNSDPPYSPEGLNNFGLGTQRPNHGVIPNDISNVPQHINRQFNPRMGPNTSPNPPSFPQFLNSNHPTPGSYVQSISPDSNGQGFAQSNLYNALNVSSDESINGSDDIPNRKRPRMDQNMDPSFIMHAPVSGKLGAEVTEEGGQPNIRFFKYQEEQWCPMYDANGEELGRLQVHVLADKGFNYSTNDNCFVNQKKNHFQVTVKIEAIDPSPPQCFKINGVCKPIENFQLSFVGAKSESQNSEIPIRQSTTERKPILHTPVLFKIVERRMTIVTVPRLHFSETTLNNQRKNLRPNPDQKYFNLVVRLYATATDGTTVLMQAFASERVIVRATNPGSFEPPEMVDASWNKNGGILSTNGPVVIGKSEPRAQLTVDGDIYSSGRVMYPSDIRLKDNITEKGAKDALENLQKLRIVDYFYKPEVASKWGLTEDQRKRTGVIAQELAAVLPDAVKDLGDYLTVNESRVFYETVLATQELCRLTGDLDQKIDDKVAEISQRLTQYAQKKKMLNSMASGLNSEGRSLNASRTSLDSSASALTLTNTKKNRRSSRKDKKDAPKSKMTHGTVIGLVGVMAFCLLAMSALYILDWHNRNFGYHHFTPSATTSGPKEGPGNVVIPLDHYVPLRQPDAPPLVPFCPMETCRGYCCMEYDKDHAELEITEYDPNTATDNDFGFKADTRSDFTLKGFGNNVKISLPELGMQIDERYCIEKSCVKKRKVYSLFIPMTRYLPNVPLEVQIDVPSSKVVNNCGYIQEFDNRKCDETGSSSTETDAPRSIQLFDNTFQVSAGQWTQSAYRFRVGYSTELCSIDDTHFGGFYEEYNLIFYRACNRTNSTAINVV
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA > DGPP > LPA.
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The phosphatase sequence motif I (including Arg-143) and II (including His-189) are part of the cytoplasmic loop 2 and phosphatase sequence motif III (including His-235) is part of the cytoplasmic loop 3.
Sequence:
MISVMADEKHKEYFKLYYFQYMIIGLCTILFLYSEISLVPRGQNIEFSLDDPSISKRYVPNELVGPLECLILSVGLSNMVVFWTCMFDKDLLKKNRVKRLRERPDGISNDFHFMHTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKMSDSDSLVFGLDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTYLWQRVFTTRNTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWTFTNLAKRDILPSPVSV
The following text describes a protein:
Function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MKNRIPVVLLACGSFNPITNMHLRLFEVARDHLHQTGKYQVIEGIISPVNDSYGKKDLVASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHGELLRSVAQMDGPDPSKIPSASAALPELKLLCGADVLKTFHTPNLWKDSHIQEIVEKFGLVCVNRSGHDPKRYILDSPILQQFQHNIHLAREPVLNEISATYVRKALSQGQSVKYLLPEAVITYIRDQGLYINDSSGKGKGKTG
The following text describes a protein:
Function:
Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.
Subcellular Localization:
Preautophagosomal structure.
Sequence:
MSLRERPGSSSNQDRREPRYHVYVRLPFNRGDFVDPPPVSWDDRKSEALWTIISGVSQTEIDWHELAVQFDVTVEFLLQMVSYLTERHTAQLRAQMRKAASGRGSAAPSPIPGGEPVGYAEGLRRAGSVGGRTSALSMRKEALAPKDDVNTPGIPTAKTSSNTLRPAISRNSSQTTLIPGQNPSLGAALPTTTNNKIASRLSDPQRRRVSLLSINTKDASSGDAIHETDDNRSYRPPESPSPVASTSPSSDDSDYAEQMQSRYIRRPPRFQSAGQSKASDDDDDELAFLPPTRTRQHQHQQQQQQQQHQPKFQQRHNSDNNNNNKSNNPTGSTSTSDGSGALDLYATVTKLPLNYRDHQSSPRNRIGSSGSQNQQQQVGHGHSLSSTKNHPQLSTIQSQTSDSSTSSAAIIPSNPRRLASGELRVGTSGAGGTGGPGARLPGPLSPRRIDMLSREGSEGAPSMGSSFSDLDDASVTQSALEEALASRMQDGTIGSRMSMIGHTIRSKYLPSKGNRP
The following text describes a protein:
Function:
Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIQWYPGHMHKARKEIEEAMPQVDLVIEVLDARIPYSSENPMVSKLRGDKPCIKLLNKSDLADPEVTAQWIEYLEREQGVKATAITTLQPGMLKMLPDLCRKLVPSRDKTEKDIRTMIMGIPNVGKSTIINTLAGRVIAKTGNEPAVTKTQQRINLRNGIVLSDTPGILWPKVDNEASSYRLAVTGAIKDTAMEYEDVALFAAGYFLKAYPKEICERYNISELPKDDMALLEEIGRKRGALRPGGRIDLHKASELLLHEYRSGKIGLLSLETPAMAEIEKAEVERILAEKAAEKAAKLEAEKLKRSGKRHND
The following text describes a protein:
Function:
Component of the transcription regulatory CCAAT-binding complex. Required for the reprogramming of the cell for iron use. Down-regulates pcl1, sdh4, and isa1 underlow-iron conditions.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Iron starvation induces nuclear accumulation and iron induces relocalization to the cytoplasm, in association with exportin crm1.
Sequence:
MESSKSPSEVEKSSSASPAPQKPMIRVSKQWVVPPRPKPGRKPALDALGRRKAPIKPRPGPTSALSVEEAKFRVREKQYQDTIGKLQKENNELLEQLEMLQAQLKNSTLDSPKEVEVNSEVVKPDSATTENENRYVNQYNYPVEPPCAKNAVYTEIPIELDPHAFLGDSAKRIRVDSDSKDAKSVPSENGRIRVSMSPQNEINFTPENPAVMEKIRKRGVCNSVEGCLYSGSPKSVKRVRESEETKVYAQLLIDLHKSSKSAPMLKAGPSIAFKLPTMEPNFNDVRPVTSISSSS
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MAVQPPPDSVVDWEAVDEEIKSVPSEYREPRFYPLKHVVEVFSSADPQGLTQELRDTSERLGAQLDAVVEGYHTGFARSIQNYSQILALFAESKEQVDAMKHSLADAAKQLGAHSRFMSTQWRKTVSLESSLRLLADIRTVVEVPGRVDTALAEKDWPRAVSCLLEGATLMAHAELRRVGALRKLRSDMVTLAGWIQDQMVDELSQRIYSGARASTSAPSGGDAGGSSGAGTGGGGKAADLAAKLGALESARTRRAGGMLLLPGKEAAPQPGWRRKGQEPAYKLVTDTLRSSRTASTELRGALSLGTAGALPPGPGPGPGNGAGPGGGAGAAAGGRGAAGPGKGPGAGAGAGVAVTGGGGGGGGGGGDITVDIEGAMRHVTTRELVACLAQVDGVGDAKSFVARQARSEMRKLIRRSIDAFLAQAASGLEGRGLGLIAGELLAPAGGGNGGGGGAGGGSGLGASSASLSPVVRVLAQRLVMHVAGACLQALGRMQHVLAELAAAPATTQSSALDVLGSLRVAAAGGGGGGGIAGPPLGDGSPRSRRGNRNPGGGGLTARERAAYLREEYGRMWDALQEELQQLLGEVLQSGAAAHRRPGAAAARVGAGGGGDGKGPGGGGGGGGGRVGGVRGLLSDLNPVHFLEQLSALAERTADFAENALGGNLSMPPAPNKPSPSKGPSGRGTAAAGTSAAHGQQQHPHQQHAAAAAAAAQRPPRRNLNSKLTFGFDITVPGLAAGDSTQIWGGMVLRGADGDGAGYGPLVSRALGERPGSVYLLAQVYLPAVRLVARAEELLRLPPDLAAVGEGGGKGGGGGGGAAGPGGGVVVGSWLQHWLEEVALEQLLPQVWVELRGRCTAALDDAEAFRPQVGFSAAAAASLAERSAAADAAAEGAAAAAANGSASSAAAASAAAAAASPPAMAPRAVVPLARFLEGVLRELVGGAAALPPFTGAFLAMAERILDRMLGAFAHMVRLVSADCPSVRLVGRSDVCLAMAAETDALLLREPVAFAPQPYALPGSGPGPGAGGGVSATELVAFVVSLRTQERPLLVPASLRPLSSGAGGGGGHRGPAPGFGADGDAAEAELHYLAMRERPQPAERLLLGQGSPDRAIQLAALSESLDYVAEAVVRLSATGVGAAGAGGAQQQPAGAAGGRGLGKQRTRGRQQQDEAAGSGAGSVPELLLPVVQSYKALSGHCSRLLRLEALMLVAAHLAPVAAASHLLDEDEALELPASLGSLTRTCLRASEELAPFLQPAKRAYVFGPLAAATARGMMWLLPAIHDINGLGVERMIRALTVMQPPLTSLVAIAPGTANAAAAGGAGKGGAAGAAATASAAEAAAAAAAAATAWPPVSGTGPSAGVMAALLMQPESRAGERSRVWDRSRGYYGLLLVPPDEVVRAAGERPGRFAYAEWMALLQARVPGRTVTDVGLGALQRCLDRAYGLTPGAKMAEVMGAVVGAVQAPAERLGDALLEGLAAGKDSVLEALVAGRDGLVAGVRVPAQTLQRVFRKIGAGAAAAARAGRGKRQQAAEGQGQGQGQQGAGGE
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKKVKPEFDSADQLSRIELYKRLDQNNPLNQGMRPYEGFNGPKKERSMTDRLCLLFLLLFFCATVFHGIVLISYGNINRISNGYDFRDEICGINGLINQPYLYYLQPSVDMNVAMCVDECPSSTGKYTCLYSIDHFTTTNFCYVQMSSTKMARYCIPKEPVSRKIVDDFLSQTEPYIKRTMSDILLSLDLIIVSIILLGASAYFLTYLLSFPSIVKFQVWGQIWLSIICFGILSYLFYREYERVIDTRCLYKIDKHQCGGDRATLFYLAWIGTAGIGLLFLFNIMKLFNKINLGISLIKTSSQIVLVLKQLRFFAIFVAFIGFVQLGYSCIVIFYGMTIGERSTVQALNINGDAVKIFTTTQIYQLSLPFQAFMILFFLLFVMSVNEMFNTYALSVWFFTKRKDVVQIPLLVVLRELLLHHLGSCVYAVFMEIFFFIPKWIFYTIYYFLSSLPQDSMIVRFIQGCCLCCLACYQNCLRYLSKHALVQVAIWSEGYSLSSRKAYFLQDRHKEKIHDLDFLIEFILFLLKLSNSLVISLPIYIYLSVSDTTLLGVKVADIESPLIPTLFVFLIGFFYVSVFQVSYDITTKSVIQLYLVDREMFYGEQRFVEDFIQKFMEFYGKKEVDQIKIKSNAQRKYNAQVVPENINKELDEQSYQSEEQEEEEDEEEEQEEELEDINLQDDNSSPELGNDYNGKNKTNAHHIVADPFQLDDASDSRSQTQWKSGTNFNK
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MRSTTLLSWLLSAFVALILHTTIASQQPRKGPVVVSKVYLDITRGDKPLGRIVIGLFKRTPKTSENFRVLALGNTKSASGTPLAYKGSSFHRNHQKFYFTKGDGTGGESIYGSKFKDENFLYKHEGAGTLSMANAGPDTNGSQFFLCTVVTSWLDGKHVVFGKVIEGMDVVYDIESSKTDGRDRPIEKVTIADSGELEIEDEVDEEGNKFGVKGNGNLLASSSSSSSYIKTSSLKETVTWSREVDSL
The following text describes a protein:
Function:
Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. Slows down the inactivation rate of the calcium channel CACNA1C.
Subcellular Localization:
Cell membrane, sarcolemma, T-tubule. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEETPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFETLRTGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI