lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Stimulator of ATPase activity of molecular chaperones of the HSP70 family (principally of the SSA class). Stimulation is important for HSP70-substrate complex dissociation after folding of newly synthesized or refolded proteins. SNL1 is probably involved in nuclear pore biogenesis and in particular the folding or refolding of misfolded NUP116, GLE2 and NIC96.
Miscellaneous:
MISCELLANEOUS: Present with 3346 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus membrane; Single-pass type II membrane protein.
Sequence:
MSHNAMEHWKSKLSKTSTSTYVLLAVIAVVFLVTIRRPNGSKGKSSKKRASKKNKKGKNQFEKAPVPLTLEEQIDNVSLRYGNELEGRSKDLINRFDVEDEKDIYERNYCNEMLLKLLIELDSIDLINVDESLRRPLKEKRKGVIKEIQAMLKSLDSLK
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MSIVTVQLGQCGNQIGLSFFQTLMSDLAHSTVSSNQDYKDECLERFFHQSLEEGSSKTTPSARAVMVDMESKVIQNTVATAKKSGTWRYPDKQQFCRKRGAGNNWADGFYGHGSVVEEQVLEMVQREVEKCDRFGGFLSLMSVAGGTGSGVGTRITQCLKDRYPQALLMNQLVWPHCSGEVILQNYNAVLSLAHLYECADAINIIHNDHMRKICSSFSSTGSSNSGVSFTDMNKLIAEHMAILLQPSHHSGRSSTVCDMMGTLVSHPDYKLLTMYCVPQTSEGSLPFSTFAWPGLMKRLHQMVVNASVMEEGLNWQVKPGSTHSNKCISNHLILRGKDSTTADISPLRNSALYVGWIPSDFAFTCSHQSRQFRAYEKSACLMSNGRTAVGSLNTIVRKAWDMFAMRAYVHWYVRHGMEEEKFIDSFASLEQVLDNYKQI
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MASETSKPSHLEPSPLGTKEYWDNLYNREISNHALDATDVGTIWFDDSSAEDKVVDFLNGEVFEKDLLGLGEVRKRQDFSLLDLGTGNGHFLVRLREGEEDSEEEEEEEEEEEEKGKNDGGTKWIGRMMGVDYSERSIEFAKRIAKDKRESEQEGTVDGNEIEFITWDIMKEDPSPKVLNGEQANGWDIVLDKGTFDAISLSEETDSNGKRIFEGYREKVLALVRNGGVAVVTSCNWTEEELIEWFIGKREEEGRDRFEVLRKIEYRSFSFGGVKGQTVCSVCFRKRGESK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
CSIACCSNENDITERLKRIIQANARLLEDISDTSFQNKSLSAWVDLQMEVAQYINSDVRGVPLHLQASKPMSGFTQRLKGKQGRFRGNLSGKRVEYTGRTVISPDPNLKITEVAIPILMARILTYPERVSQHNIEKLRQCVRNGPNKYPGAKFIKHPDGTEISLMFSSRKRHADELKFGYIVDRHLEDGDIVLFNRQPSLHRMSIMSHRARIMPWRTLRFNESVCNPYNADFDGDEMNMHVPQTEEARTEALMLMGVQNNLCTPKSGEILVASTQDFLTSSFLITRKDTFYERASFSLICSYMGDGMDPIDLPTPALIKPVELWTGKQLFGVLLRPYSKMRVYVNLTVTEKSYSGKGETMCPSDGFVYFRNSELISGQLGKATLGNGNKDGLYSVLLRDYKSHAAATCMNRLAKLSARWIGNHGFSIGIDDVTPGEILVKQKLEEIHQNYKKCEDRIQQFNEGKLAVQPGCDAAQTLEAEVTMSLNKVRDDIGKVRTTYLFMCCVFPTNSRHLWDXGHVVHYLWFQEWEREGMIHQLQLCYIKEEMLKVIIDVTYALNCTNCLYVRPLMLITVMFLVQAKGFVAHSFFDGLSATEFFFHTMGGREGLVDTAVKTADTGYMSRRLMKALEDLAVYYDNTVRNASASIIQFMYGDDGMDPSQMEEKKGRPLNFSRLFMKVKATCPPRGEKSLSYSEICEIVNERLSYHDMSPEGGCSEAFRASLSDFLIKHLAETLKRLREALLLDGEQYAGGDREYLENIALNISGITKKQLQVFLNMCISRYHLKRLESGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINAAKKINTPIITAKLLSAANLTAARMIKARIEKTLLGQVAKSVKIVMASRLASIAITLDMETIQVSQLCIDAYTVKQSILQTPKIKLKEQQVKVLNHRKLEVFPQANKDKLHFELHRLKNKLPAVVVKGITTVQRAVVNKEQERDRKSDVKGETYELLVEGTGLLAVMGIDGVDGHNTKSNHIMEVQQRLGIEAARISIIDEINYTMSSHGMTIDLRHMMLLADLMTYKGEVLGITRHGVQKMKDSVLMLASFEKTTDHLFNASVNGRDDKIEGVSECIIMGIPMQIGTGMFKLRQCVQQVELNYQSEPMLS
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain (By similarity). The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Required for the maintenance of muscle integrity and for cell proliferation in the wing imaginal disc epithelium, possibly by interacting with the chaperone-assisted selective autophagy (CASA) pathway.
Miscellaneous:
MISCELLANEOUS: Displays weak sequence similarity with mammalian NDUFA3 but is present in the density map in cryo-EM structures in the location of mammalian NDUFA3.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to sarcomeres and Z lines in larval muscle.
Sequence:
MSASAARGSTSLLKRAWNEIPDIVGGSALALAGIVMATIGVANYYAKDGDNRRYKLGYVVYRHDDPRALKVRNDEDD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAARKEDLGLAASHNMDSGRIAKSLYTMTSTNNETFLEVKDEPEAPQFVLAGRRYRCLTCHKTFPNQPRAQRHCEANHSDRDPSSPNTKKRATKCEQRHQCVHCNKSYKSASLLRNHARSHTGEKPFACKECGRSFMQPICLKVHMATHSGQLPFPCEHCGKAYATPSKLRIHQRLHTGERPFSCPDCGKGFADPSIFRKHMRSHAGLRPFQCQLCDKSYSELKDLKNHERSHTGEKPFLCSDCGKAFSRASSLTCHLRIHAAEKPYKCTTCGKDFTQLSSYQSHQRTHSGEKPYLCPQCGRMFSDPSSFRRHQRAHQGVKPYQCDKCGKPFRQPADLAMHQRIHTGERPFRCPDCDKSFVASWDLKRHRLSHSSERPFQCQECGKGFAERSGLSKHQRSHSGERPYKCLECGKSFVVSSSLRKHERTHQKPEQDATKKREETTTCEKCSLSFPSMMDLRNHQKTHPELRPFRCDQCEKGFVDKAGLKKHERIHSDVRPYVCSTCGKGFLVPSDLRKHQRTHSKEVKEEEEITTLTLHPASVEPPPLYDPLVSFLEKVAEGNMEVIDPSPSN
The following text describes a protein:
Function:
Has strong anti-HIV activity against T-tropic strains of HIV-1 and weaker activity against M-tropic strains of HIV-1. Inhibits HIV-1 fusion and infection of CD4 LTR beta-gal cells in vitro. Inhibits fusion of HIV infected CEM-SS cells with uninfected CEM-SS cells, and fusion of HIV-1 Env expressing HL2/3 cells with CD4 LTR beta-gal cells. Binds to HIV gp120, HIV gp160 and to a lesser extent HIV gp41. Binding to HIV gp120 is glycosylation dependent. Binds with high specificity to the tetrasaccharide Man-alpha-1,2-Man-alpha-1,6-Man-alpha-1,6-Man and also binds the higher-order oligosaccharides oligomannose 8 and oligomannose 9. Does not bind to monosaccharides, complex or hybrid N-linked oligosaccharides or chitin.
Sequence:
GSGPTYCWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQGTSRKPDPGPKGPTYCWDEAKNPGGPNRCSNSKQCDGARTCSSSGFCQGTAGHAAA
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of dre2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Sequence:
MKNSHIYILYGSETGTAEGLAESLFRSLTRMGYDVLVNSMDDFNLENLLRPLQCVFICSTTGQGEMPLNMRKFWRFLLRKKLPNTFLNDMQYAVFGCGDTSYTRFNWASKKLDSRLRQLGAQSFSSRGEGDEQHPDGVEGVFAYWCNHLYSQLAAIKTPSRPAFGEFDLLPPSFQIIIDESLGCKVKGFEDNNIVRHSRGKIEATLVHNKRISNIKHWQDVRHLAFKIPNFERWKPGDVAVLYPWNDDMSVNSFIECMGWESIKYSPLIISSNVAERKLPWFPNILNVFNLVKYVLSIHSVPSRTFFEMASHFSNNKMHKERLQEFSSYKNIDDYYDYTTRPRRTVLETLQEFKSVQIPIEYALDAFPVIRGRQYSIANRCDNSTGILELAVALVKYQTILKSPRQGICSRWICDLHENTSFNIDILPGFLNLSYQSNKPLIMVGPGTGVAPLRALIQERIYNGLKENLLFFGCRNKSMDFLFEKDWEKYTEEGTLKLFCAFSRDQEKKKYVQHSIQENGELVYNLLNEKDGMFFVSGSSGKMPSSVKDAIAGIVSKYSGCSISDGYSFVTSLEKKNRYYQETW
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. AHA motifs are transcriptional activator elements.
Sequence:
MEKMMPGMVKEEWPPSSPEEGEAPRPMEGLHEVGPPPFLTKTFDLVADPATDGVVSWGRAGSSFVVWDPHVFAAVFLPRFFKHNNFSSFVRQLNTYGFRKIDPDRWEFANDGFLRGQRHLLKMIKRRRPLSYLPGSQQALGTCLEVGQFGLDEEIDRLKRDKNILLAEVVKLRHKQQSTKANMRAMEERLQHAEQKQVQMMGFLARAMQNPDFFHQLIHQQDKMKGLEDTFSKKRTRSIDIVPFLNPGEVSQGDQLESTLLFDPRPFAELNDEPAKSELENLALNIQGLGKGKQDVNRTRNQPRNQASNETELTDDFWEELLNEGARDDAGIPGMERRRPRYVDALAQKLGYLSNSSQK
The following text describes a protein:
Function:
Inhibitory regulator of the Ras-cyclic AMP pathway. May function as a negative regulator of Ras85D/Ras1 in the sev signaling pathway. Acts cell autonomously in cone cell precursors as a negative regulator of R7 photoreceptor cell determination.
Sequence:
MLLKKKRYMFDERDDNNINSPVAVEPSSNNNKMADTREVRIEEQLKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRRFRYLTIYLWDRDMKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPIGDDNYWHMMRAAGQLNQQHHQQQQHQQQQQQQQQQQLQQFQPQPVLPQMQNVRAYPYQPATSNMNAYCLHNMQYQQQRLPFHQQQQQHHQQLQQQQSQFQPLRSHQLQRHNNNLNNNNCGNGSSSSPSSTTSSVVAAPPSTTSSSQPAPPIY
The following text describes a protein:
Function:
Probably involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS). May be necessary for the attachment of a rhamnose to the LPS core by a linkage to the KdoII residue (Probable). May also play a role in a lipooligosaccharide (LOS) biosynthesis pathway.
Sequence:
MTIYFINWVADYELKMIQYLKKKYKIKNITTPKKYNWINKKISKIGMDNAWLGRLFIKHYLNDIKKDDIIIINDSVVNKGINKQILKNINCHKVLLLRNTVGEDFILDNANYFDIIYDFEHRFIGNEKIKAIEQFFPIGMDEIRNYSLSDKNNSQPICFFLGRDKGRLQIINELAERLTTLGCKLDFNVVKDKTSSTTSKYLIEKQISYEENIRRTLNANIIVDITKENQSGWTLRILEALFFNKKLITNNINVFGSEIYSESRFFIIGHDDWDKLEYFINSSVKPMDYDSLYKFSPDKMMSTIVSDFIDK
The following text describes a protein:
Function:
Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MASTPPQNSKKVRNNSGSGQTVKFARRTSSGRYVSLSRDNIELSGEFSGDYSNYTVHIPPTPDNQPMATKAEEQYVSNSLFTGGFNSVTRAHLMDKVIDSDVTHPQMAGAKGSSCAMPACDGKVMKDERGKDVMPCECRFKICRDCFMDAQKETGLCPGCKEQYKIGDLDDDTPDFSSGALPLPAPGKGQRGNNNMSMMKRNQNGEFDHNRWLFETQGTYGYGNAYWPQDEMYGDDMDEGMRGGMVETADKPWRPLSRRIPIPAAIISPYRLLIAIRFVVLCFFLTWRIRNPNEDAIWLWLMSIICELCSSSDLPGIDLVVSTADPEKEPPLVTANTMLSILAVDYPVEKVSCYLSDDGGALLSFEAMAEAASFADLWVPFCRKHNIEPRNPDTYFSLKIDPTKNKSRIDFVKDRRKIKREYDEFKVRTNGLPDSIRRRSDAFNAREEMKALKQMRESGGDPMEPVKVLKATWMADGTHWPGTWAAATREHAKGDHAGILQVMLKPPSSDPLIGSSNDKIIDFSDTDTRLPMLVYVSREKRPGYDHNKKAGAMNALVPMNALVRASAILSNGPFILNLDCDHYIYNCKAIREGMCFMMDRGGEDICYIQFPQRFEGIDPSDRYANNNTVFFDGNMRALDGVQGPVYVGTGTMFRRFALYGFDPPNPDKILEKKESETEALTTSDFDPDLDVTQLPKRFGNSTLLAESIPIAEFQGRPLADHPAVKYGRPPGALRVPRDPLDATTVAESVSVISCWYEDKTEWGDRVGWIYGSVTEDVVTGYRMHNRGWRSVYCITKRDSFRGSAPINLTDRLHQVLRWATGSVEIFFSRNNAILASKRLKFLQRLAYLNVGIYPFTSLFLILYCFLPAFSLFSGQFIVRTLSISFLVYLLIITICLIGLAVLEVKWSGIGLEEWWRNEQWWLISGTSSHLYAVVQGILKVIAGIEISFTLTTKSGGDDNDDIYADLYIVKWSSLMIPPIVIAMVNIIAIVVAFVRTIYQAVPQWSKLIGGAFFSFWVLAHLYPFAKGLMGRRGKTPTIVFVWAGLIAITISLLWTAINPNSGPVAAAEGVGGGGFQFP
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Sequence:
MKILLLCIIFLYYVNAFKNTQKDGVSLQILKKKRSNQVNFLNRKNDYNLIKNKNPSSSLKSTFDDIKKIISKQLSVEEDKIQMNSNFTKDLGADSLDLVELIMALEEKFNVTISDQDALKINTVQDAIDYIEKNNKQ
The following text describes a protein:
Function:
This protein is involved in the initial step of iron uptake by binding hemin, an iron chelatin siderophore that allows the bacteria to extract iron from the environment.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEAPMMVTVIEGNAPTSQTAATAADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGVRQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGGVIAYETVDAADMLQPGQNSGYRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSNGFNAPNDETISNVLAKGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLDQEWLNATAQVYYSEVEINARPQGSAEEGREQTTEGVKLENRTRLFIESPASHLLTYGTETYKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSILAGTRYDNYSGSSDGYADVDADKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNPNLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNIDQAKIWGWDASMSYKTALFNWDLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFSVGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKGMTTTMLLGNVFEKEYYTPQGIPQDGRNVKFFVSYQW
The following text describes a protein:
Function:
Unknown function: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP).
Sequence:
MMAGRKGYQSVMDENCHDKTESAYTDDRSLNGSSGSSCLKNNVIAFFLGAAVVAATQYVSIDSSLTKAVEVTSFTTSDAPAIDIAINPTRPSLDARQDFKIEGWGNQTRNDGWPSFHFEVFHFCPHLINFMYENQVHPQSRVDPSNVIYDAQHPGALAEDGFAEVLQQTLPKFYDYPVGYRLNDRPAEISAYWTLHMRIARGSEDSQWHDFASSLPEGINRIYVKKPLQWNGDHVTLFSSQTGYNILVY
The following text describes a protein:
Function:
Transcription factor (By similarity). Required for sex-specific synaptic pruning, probably acting downstream of sex-determining transformer protein tra-1.
Subcellular Localization:
Nucleus.
Sequence:
MPVSPSSVSVLPPTSLEQILRIRAERNQRTPKCARCRNHGTTSALKGHKRYCQWKDCMCAKCTLIAERQRVMAAQVALRRQQSQEERDARDLEVLLGSAGNANDLLDILRLDAGEHHGKNHASPTTNNNNNTEEKYEDSQGQRSSPSSPTGSETVVSTSSPPELSSESTPNTSGSVIPTSPVFKPNGYSSMPMFNPVYGRPFMRFPMFSVMPHFFGTPSMSDFASAASLAAPPAFFSAQPTIATSSPSTIFPQTAPLDYSHRLMKNEEAEEEYRENDKTF
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.
Sequence:
MEARALEHERRLAESHGQEALKHAIAAAEIYMRAAEKAANPKDRNRLQRKCSDLIALGERLKANAKSAATSARSPVPESTRTLTIAEKTLLLKSSKLHGNIFPPWEKTPASDEFAASKAADGCFTDHSPFTLSPEQQDIFAGWKRPHEIFMDVPERGVDVFMTATESIDLGQDLATDCSVVASLCAAVRQFGPRTGSLLSSLMYPYDDDVKRPAVSQNGKYIFRMYFNGCWRKVLIDDRLPTSSSERTLYVVDRRNPYLIWPALIEKAYLKIRGGYDFPGSNSGTDLHALTGWIPEQIFLQTDDIELNETWSRIKTAYEQGNALVTLGTGKFSREEERTLGLVREHDYAVLDLRNDGNNRLFLVKNPWRDSLVWTGVGSTATSSTDRSGSPEESMSNTFWMTFEDVLQHFDSLYVNWSPSLFRFRQDHHFTWTIPPKAEELVFTQNPQYSILSHTGSPVWILLNRHWQDSELDILRERKQEHDFHQPLKSLGYMSLSLFASHPPGTRIPLSEGSHHALHQGPFVDSPNTLLRYSPTPGVAQTLVIAQSDLPLPSYSFTLSFFSNSPLTISPASDPLPYNETITGAWTRRTAGGSTVYPSYVTNPQYALTLTRPSPLSLVLSTERADNLPVHIAVLYSNGGQRVTAVVGRDLICSSAEYQRGCTFASTLPSSNTSNVTSSVASNNHGHTSSSLIDPGTYTIVLSTYEPGQTGRYSLRVSAACPFTIEPILSDAAGRLRTPAPSPATFRQGEGRVRARVDVARLTRASVLARSVKTGSTTQKTAMVRVALELGTIEGRKRVLASTASGGGGELAASLSNLSLSERLGGIGGIGGGHIHGGQGTTEGDGYSAKGEFADASLGLRTREVDLDPDVIRVYGGLWLVVEQIGGGGQGHVTEGSDDDGGGGGGGGGGVHVEISSDGVVSIGEWEVADED
The following text describes a protein:
Function:
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). May play an important role in the inner ear development; (Microbial infection) Plays an essential role in Aichi virus RNA replication. Recruited by ACBD3 at the viral replication sites; (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
Subcellular Localization:
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3. GGA2 is also involved in the recruitment.
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MSDTKWKNEAKGFSEHVHLGNFSLDENRNYCDDHRNRKFFVDPGLWPKFDLLPGHSEYVDRNRGDDDDGVDVKSLDVLLRWMRDHQDDLQRRKILEIQADGSKRLALDFVTRRGALHDLFKSAHLNDRTEYLVTFFKGTYYLEQLELPGRHDNPNDPDGTQVYSGKKFAQYCTSGECARLVAYPAEDRAGENGAKPDTTQPINDNLSYEAVMAARCGDFKLMFAVEVHAESKDNREIPSTYRGLHHLNYVNIRTTRDFNALTELQQSKAFFRKKLFQFWSQNHIAGIPRVILGWRDDERHVITRAETYKTEDIPSFPLCSWKPGKYYAAIQTLLTEITRLVTNDDDPGYVNNFVCLTVCLVYDLSICFVVHHLVLERVESAPYPELAAKLCNRTFKIKRHADGHHRIVTDWFIKDVLNIK
The following text describes a protein:
Function:
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPGPDDDVREPTAAARTNNSGYGLRAAPSSITSGLDSVVSVNSYRSSELNAEEVNVDDQECADSDILESPNDGMTIMNDDDADLSEEEEEVMENSIDFSVNRATVTKAGVIPCCVFVGRVRWGTTDWEIYFGQKQLLRLHFNLHLYSLFNRHKLLRGVHLPCTIWREKRAEKRVMDVYVVQDYIRQLLKDRDLRNSEPLLSFLEVSPSRAMLRLGPSLKEGYVHMRINGPFQLPLYTCFNRTIEALYRHLYRAWMRIAFVSAIVGFIFPICLVIVTSLPTFFSPQKELVNSDSGTKEVSTKLNTAGVFLGLAVLGGILFFAVFVYKFFQHRLGVIRRWVVLKPSCFAAYRNRNDREPSEVFLFDKNFTARKGSYRQGVSWMPSGLVVGSKAGDIEIDTGHYYTRLTAFVALMGVCYGIMRLSNSIYDFEYLSLDKSMGVPITNASGYENWTESRDAEYCGYYFIVPKGTTVYVESKDDSAVISQLQMPSSNSMTANLGFFWQSDSMGYSLNVITNAVGAGTMVSVVKPIDAKNDRFFESGTNYSMPTVGNLTLEGVKTDIDVQSFSNVESFCAITVRIAPLTWRSYVYYILFLFAGGIIAPVVGFLANYFVTYLGIWHPHVRRDHWFRCVRRLQKLKRQETSTRFNSFAPQHISTIDDDESATITAKAKAAKLAIGNTPTSNINQVVDSVVKQEAETASRMGTGNLAPASSRVDSSTQSEDSFEAPKPPPSSVSWHVDAEDTYAAMYKAISNAKYEILIAGWWVCPDLFLLRPGRKLPPREADEDPDGQQVNKTMLRQVLMKKAEAGVKIYVLIYREVKLALTLNSAYTKRSLMVHPNIRVLRDPIFQIQSLGFWSHHEKIVCIDQSLAFVGGLDLCFGRYDHHGHPISDPSDDPVWTGKDYSNPIIKDFVRVNKPFEDLIDRASQPRMPWHDVHCSISGPPVQDVAYHLIQRWNFVCSKNDYQLRTGWCICFRSRRFKFLPKCLVPMDFNGWTLQYPSSDPEPMRDGSTRTTIPLVREDSLSMVEPFQVVQSVNPMYPCTATGPQWPPTSSLHPINPMRPPLTSASTTTGPLDDGEVLRAQRGESILQVFHPSANICNIQVCRSVSMWSAGVPTEASIQAAYMDVIANSKHFLYIENQFFVSGMDGNGIVRNRILQALVDRIERAVQRDEKFRVYVVMPLLPAFEGNIRSHELTNLHAVMHWQFATICRGRYSLFEALKGVTNHPENYVAFFGLRKYGIMPNGCAATEQIYIHSKLMIADDRCAILGSANINDRSMNGDRDSEIALVIEDMQYEDGVMNEKPYRRGVAASKLRLQLFREHLGLADDDLSVADPTSDHTWQAIKSTASSNTKIFEAVFDCAPSNRMRAFVNFQSIEVTQIFENQRMNVLKVPGRSHVWDAQNLKDGDYAPWTDVNGVPIAADRVDLRDFEVDNYRDKKKKLFSMDHDGWCYARNFSIFQEVRTMKTDYKKREKLQHLVADRLMAQVRRRRWVKKGLLPPRDPRESSFSLASDDEEHGRFYSLWRRLQQGDFSRSNSVSTPTNFSQLDTDGGISGSVSVGGTNHGRRLYNSNSMPSNASILGDNPTTRPPVLGDAPSYPNSPSVASFQHTPQSPAIATGARSVRSARTSSLLCTGAGVRTRGNTRSARGSFYGMFSVTGNRNLDTDDESSDAGSEYGGGHGIRASLKRWYSTMDVLDFGRRSKFNAEYFDTDEDHLHSDDPLLEDGRGSYHAATREGLLTEEAVEGSDDEDAECQIGHVQTAATVRKEDETRARAQLSEIRGHLVEFPLDFLVEEILKPSVLPADIHI
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MADLLKLCLRIAYAYGRLTGVINFKIDLKTGQALVTRGATLISVSTHLLIFALLLYQTMRKSVVNVMWKYANSLHEYVFLVIAGFRVVCVFLELVSRWSQRRTFVRLFNSFRRLYQRNPDIIQYCRRSIVSKFFCVTMTETLHIIVTLAMMRNRLSIALALRIWAVLSLTAIINVIITQYYVATACVRGRYALLNKDLQAIVTESQSLVPNGGGVFVTKCCYLADRLERIAKSQSDLQELVENLSTAYEGEVVCLVITYYLNMLGTSYLLFSISKYGNFGNNLLVIITLCGIVYFVFYVVDCWINAFNVFYLLDAHDKMVKLLNKRTLFQPGLDHRLEMVFENFALNLVRNPLKLHMYGLFEFGRGTSFAVFNSLLTHSLLLIQYDVQNF
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MFFTHGPSFSLRYQNSGRIGDVHVFMKNLYRFWVYKGLWFSCLASLVDFLNSVVVFCLVVFLTTVFDWPVAAACDEVSCGTVTLTHHMRLPTERGASHVLLCLILLVSSAASATYEFLKFLETCSLQMETERMVRVIVDTGYTSPFHRLAHIWRRMRVQSDGHEELPDHGLPFIGNMAWGDFLDEVCARIQRDRSFGVIEHKEFDSLRAVQALMVYENYFITFHQHGILERGALKYADENVIRMLIRSLFDEFSTLVRGKDHVTLLRWKVVKYLVVYALFYPFVVAHFLLRVLVKNAAMVRTDWGGYMTKDWNKRALWTFSLYNEVPHVLSARIASGRQIVMEMICRLKPHSSGKRFVCRVASGIILVLLSLSLVNTSLLVSGNLCGIPLLWWLTGSIAAFSVCNETPPVEREYNYLPDLERLVKQLHYSQEEWNHSGESFYSAVTWDFLESRFSVIISDIARTLFMPCILLGLLFDGSLPALMECVQSESVRVDGLGSVAREAAFDFQLLGDGNDYPLAYHLSEKLLKSIASFSAIYPKWMLKHMPDAVPPADQSGGSATSGALDILVTKLRNRVDAETEMQVLGDPSVSALGVVNSEAEITRSSALLGKGTAHEREQLFVSHMMQSIYASKSFGIDSRTLRTAKEGREGCGT
The following text describes a protein:
Function:
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.
Sequence:
MSRSSAGFADFFPTAPSVLQQKRFKVTRERPRPKAQIDSEHSDESSACPTETRAILNLSNGGASLDSGQISSTDLKKTSPESSVEGSASSTAGDRSALSLSVAQHGANSHEARLDTLTPLTNAESSPPQKANSPRNKIAEGIVANTTIDTKSGINPLHTPPTPQSQGRRTGSIRGYKLVYDPDTEKRSSSKEKRRKPRYVDIILSEQNNCPPDPRLGIPNYMRGAGCKQKRKYRPAPYTLKPWPYDASSTIGPGPPAQIVITGFDPLTPIAPISALFSSFGDIGEINNRTDPITGRFLGICSVKYKDSASFRGGGPVLAASAARRAYYECRKEQRIGTRRIRVDLDRDGVVSERFVARTIESQRMGQKSNLQSTEEVKSDSETKKNEPPPTAPKGPSGKTSVRPIVAIPEGPRANFLKPVMPSLVEEVPILGQIKRDPYIFIAHCYVPVLSTTVPHLKKRLKLFNWKDIRCDKTGYYIIFENSRRGEEETERCYKMCHMKPLFTYIMNMESQPYGNPSYERSPSPERCRAEQRERAERERLKREVGLDIEEEKRQRAVDLDPCQEVLTIIIRDLKDKLLEDVKSRIAAPALYDYLDPDRHALKRKTLGIADPEGIKRPMFRIDDSFGTPDSRSGLSDARRPFSGSTPNILALPRIRKARHLGRTDTAFLDERRKQPLRRREVRPLYHRLQQLHDVDDSDDEQRTPKDTDEQDSRPPSRMSSGTSESDDGDGFVSEALGLPVVELAGSGQNKEPDEILKDNQSVGESSQLESNEISPELRKRKRASEELEARKRQKEDDELFGINPIAEAEVEGTQIIATPIAVDINLEVSEAALSILPKESNDNRQETGEANHLDFDGIDVTSSTIEKDRRGILDPLDDIDNAAAREESRTEVGWRVSNDEPRPIVDDDDAIIMDLDGWQNLIKDDEDLHFLRDILVGYSESNVGNLSAWAWRQKEIKALNHPGDVGPLRGGTGIAGYYVPNTTGAARTEGRKRILESEKSKYLPHRIKVQKAREEREARAKNDPHTAAVEAARVAAAKNISKSTSRSTRVNNRRLIADINAQKQALPTQSGDGDVLRFNQLKKRKKPVRFARSAIHNWGLYAEENISANDMIIEYVGEKVRQQVADMRERQYLKSGIGSSYLFRIDENTVIDATKRGGIARFINHSCTPNCTAKIIKVDGSKRIVIYALRDIERDEELTYDYKFEREWDSDDRIPCLCGSTGCKGFLN
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMNFKLSVKDINFIRPLWTYLSFVLITPWYDCNRNCLYKPTINKLTGCIFLAFKLSWIVALILDDTTQQVFEIMPFSQKCLYILTCVNLKIFIFLVVMKSCFWDVDKWRVLITNFRYVDEKLQNTGTKELRVLKNFYCGFAVKEVVFLLFVTYEMYIWSNVLELSFVKGMKLGPMIDLYYEFHFIAFLTCITECLRMRYEELNARLVRMNSSLTIVKDLRSLVQYYRILGEIIDIFNNLFGYQIILLIFHSGLQIISSLNFCFTIITHTDGPLYQHFIIANIYVLFITMFNLFMIVFPMDSTTEESKKFIDLCFKTQEYFIEDCHKIDTLTRLTNFSKHYFREFRPAGFFSIRKAIIFCFIGNVATYVILTFQFNEAIIRLM