lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.
Miscellaneous:
MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces guanine nucleotide-binding protein G(s) subunit alpha from an overlapping reading frame.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cell projection, ruffle. Note=Predominantly associated with cell membrane ruffles.
Sequence:
MMARPVDPQRSPDPTFRSSTRHSGKLEPMEATAHLLRKQCPSRLNSPAWEASGLHWSSLDSPVGSMQALRPSAQHSWSPEPSVVPDQAWEDTALHQKKLCPLSLTSLPREAAVNFSYRSQTLLQEAQVLQGSPELLPRSPKPSGLQRLAPEEATALPLRRLCHLSLMEKDLGTTAHPRGFPELSHKSTAAASSRQSRPRVRSASLPPRTRLPSGSQAPSAAHPKRLSDLLLTSRAAAPGWRSPDPRSRLAAPPLGSTTLPSTWTAPQSRLTARPSRSPEPQIRESEQRDPQLRRKQQRWKEPLMPRREEKYPLRGTDPLPPGQPQRIPLPGQPLQPQPILTPGQPQKIPTPGQHQPILTPGHSQPIPTPGQPLPPQPIPTPGRPLTPQPIPTPGRPLTPQPIQMPGRPLRLPPPLRLLRPGQPMSPQLRQTQGLPLPQPLLPPGQPKSAGRPLQPLPPGPDARSISDPPAPRSRLPIRLLRGLLARLPGGASPRAAAAAACTTMKGWPAATMTPAETSPTMGPPDASAGFSIGEIAAAESPSATYSATFSCKPSGAASVDLRVPSPKPRALSRSRRYPWRRSADRCAKKPWRSGPRSAQRRNAVSSSTNNSRTKRWATCVRTACCF
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMAGASQSKRLLVACLLLSLGLASAAGPTVEPIGASDRSAAVSLFKVQDDGSYGGLKETYEAAKVFAALDSFPADPSKTFAYLKGVKPGDVEAAFYAIGAAAALKHPEAQMSGQILVASEGLSKGTTLDELYHGAVALATAKKAGWLKKNSVDKKTLQAALKKLQAFVTEDGSWRSVDDDSDGTALASGKGLEAVAALIELGLSTSEAGVQEIKGSVEKLVGSAEASDDSFVFFDASSGSPLLSTAAVAKGALSLSAALGESLPIVEKLPGVAQYLLASKSTSSPVLLSELVDALSIISTNSFSVPLVVSLAKTSLSLKSNDKLEVSVSTPLGAPVAAPVTLKRAKRAGAENALFTNENLEGGAFDFLASKPAVGKYTLVLEVEAPERHAVVSPVKKELRVLGSATVSDVMLTVEDDGGAKKEHKVPASKDSFRAAKVSATHSDKLGLQFKVIGPDGAAFAPQQTFVRLAHKSGVDALFPAKGAGGAYSFELGLGEVRDKMYHQSGAYTLELILGDPFIENSLHTVVANLDLKLPPAPEGAPPPPADLSEDVAPPAEIAHIFREPDKRPPTAVSTLFTALSLVPFVGLLIGFAALGVSFKGFPSSGPALISAVMFHTGLAAIAGLYVVFWLKLNLFQVLGALAVLSVFTAFSGHFILSSLADSKVKTA
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRIVAIDYGRKRTGIAVSDTLQLIANGLTTVPTHELLNFIGGYVAKEPVERIIIGLPKQMNNEASENMKNIEPFVRSLKKRFPELPVEYVDERFTSVLAHRTMLEAGLKKKDRQNKALVDEISATIILQTYLESKRF
The following text describes a protein:
Function:
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Sequence:
MNFDLVIDAENKILGRIASLAAKELLKGKRVAIVNAEKAIISGNPETILKKYQTRRSIQSRINPRKSPVQPRTPDRIVWRTVRGMLPMKKAKGREALRRLRVFIGVPEELANVEKDSIIKGDVKYTIDSLKPKKSKRYITVLTLSKLLGWGGEYVSES
The following text describes a protein:
Function:
Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MEGSGEQPGPQPQHPGDHRIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNVIGHSYGTAFEVTSGGSLQPKKKREEPTAETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIITVVKPSTRILSIMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAVMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLHGTFSAEMLSSEPKDSALVEESNGTLEEKQASEQENEDSMAEAPESNHPEDQETMETISQDPEHKGPKERGSKKDYIQEKQRRQEEQRKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADTSLKSNASTLESHETEEPAAKKRKCPESDS
The following text describes a protein:
Function:
Transporter which is probably involved in L-idonate metabolism. Transports L-idonate from the periplasm across the inner membrane. Can also transport D-gluconate and 5-keto-D-gluconate. It has been reported that gluconate uptake probably occurs via a proton-symport mechanism in E.coli.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPLIIIAAGVALLLILMIGFKVNGFIALVLVAAVVGFAEGMDAQAVLHSIQNGIGSTLGGLAMILGFGAMLGKLISDTGAAQRIATTLIATFGKKRVQWALVITGLVVGLAMFFEVGFVLLLPLVFTIVASSGLPLLYVGVPMVAALSVTHCFLPPHPGPTAIATIFEANLGTTLLYGFIITIPTVIVAGPLFSKLLTRFEKAPPEGLFNPHLFSEEEMPSFWNSIFAAVIPVILMAIAAVCEITLPKTNTVRLFFEFVGNPAVALFIAIVIAIFTLGRRNGRTIEQIMDIIGDSIGAIAMIVFIIAGGGAFKQVLVDSGVGHYISHLMTGTTLSPLLMCWTVAALLRIALGSATVAAITTAGVVLPIINVTHADPALMVLATGAGSVIASHVNDPGFWLFKGYFNLTVGETLRTWTVMETLISIMGLLGVLAINAVLH
The following text describes a protein:
Function:
May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MGLEDEQKMLTESGDPEEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELYDEHVSSRSHTEEDCTEELFDFLHAKDHCVAHKLFNNLK
The following text describes a protein:
Function:
Mediates evasion of the mosquito innate immune response by suppressing midgut nitration responses that are critical to activate the mosquito complement system. It is unclear whether the protein has a role in passive evasion by making the parasite invisible to the mosquito immune system, acts as a decoy to prevent recognition of another surface protein or anchors the decoy protein. Not required for female fertility.
Miscellaneous:
MISCELLANEOUS: Exhibits a high rate of non-synonymous polymorphism is different strains, suggesting that it adapts to different Anopheles vector species.
Subcellular Localization:
Cell surface. Cell membrane; Lipid-anchor, GPI-anchor. Note=Specifically present on the surface of female gametocytes.
Sequence:
MCMGRMISIINIILFYFFLWVKKSISELLSSTQYVCDFYFNPLTNVKPTVVGSSEIYEEVGCTINNPTLGDHIVLICPKKNNGDFSNIEIVPTNCFESHLYSAYKNDSSAYHLEKLDIDKKYAINSSFSDFYLKILVIPNEYKSHKTIYCRCDNSKTEKNIPGQDKILKGKLGLVKIILRNQYNNIIELEKTKPIIHNKKDTYKYDIKLKESDILMFYMKEETIVESGNCEEILNTKINLLSNNNVVIKMPSIFINNINCMLSSQDQNNEKNYINLKADKTKHIDGCDFTKPKGKGIYKNGFIINDIPNEEERICTVHLWNKKNQTIAGIKCPYKLIPPYCFKHVLYEKEIDSQKTYKTFLLSDVLDTPNIEYYGNNKEGMYMLALPTKPEKTNKIRCICEQGGKKAVMELHIASTSTKYISMFLIFFLIVIFYMYVSI
The following text describes a protein:
Function:
Confers broad-spectrum resistance to pathogens.
Subcellular Localization:
Secreted.
Sequence:
MAKSATIITFLFAALVLFAAFEAPTMVEAQKLCEKPSGTWSGVCGNSNACKNQCINLEGAKHGSCNYVFPAHKCICYVPC
The following text describes a protein:
Function:
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
Sequence:
MESSPPTITVQVKFAGRTIPVEVPTSASTAELKLLLQPLTNVLPRGQKLICKGKVLADAASLSSMQVGDGSKVMLIASQGLHQGEGPITKNSSGLAPSAKRTSNVKDNQTLKPEIISKSRAERWKITGVIALSGSSLKAVPEEVWDCGSSIRVLDVCNNSIEAIPQKIAALKSLNKLLLTANDISDGGISWEGLSCVDTLTVLSLSQNRLVTLPPSLGTLTFLRELCIANNMLGSLPVEIGLLKQLEILIANNNRITSLPSSIGDCESLFEVDLSSNLLAELPKACGNLHNLKTLHLRNNGLNSLPPTLFKKCWRLTTLDLHGTGITNDILRQMEGWEEFDERRRQKYQKQLDFRVGSSGVFDEGADDDNRHA
The following text describes a protein:
Function:
Glycosyltransferase involved in the biosynthesis of neomycin by mediating conversion of 2-deoxystreptamine (2-DOS) to 2'-N-acetylparomamine using UDP-alpha-D-glucosamine as sugar donor.
Sequence:
MRVLRLTPFFHHDCVTAWPAEFDAVGGMQVQILRLSRELADRGVEQLVMTVGFPGLPRERVDRPGLRVRVTRAPLPRLRSELTGLVGLNQAWLAAVLTACAPLRRTWRPDLVHVHADGQLWALLAGPLVSRLVGAPYCLTLHCSRLASYEPMSRFDRLQHRLVAAAERYALRRARRVSTLTSRTADTVARLLPLDRALVDVLPDSVGDVRPVARPEAEEYVRSLGVPAGRPVVGWVGRVAHEKGWRDFVAMAERWDAGSGAPGAVFAVVGDGPQRERMREAVEAAGLADRFVFTGFLPHDAVPSVMTALDVLVMPSAHEELGGSALEAMVCGTPVAGYAVGGLRDTVGSVTPSLLVPRGDVAALTRAAGDAVTDAERHRKTVAAAVPDLLGRYGADTVERALEHYRLAVGRASGGGAGWAP
The following text describes a protein:
Function:
Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (By similarity). Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity).
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines.
Domain:
The association domain (AD) is necessary for self-association.
Sequence:
MKRWVSLDSGESEDPLPEDTCPDLLDGDSNAKPPPAKPHIFSTAKSRSRLFGKGDSEETSPMDCSYEEGELAPCPAITVSSVIIVQRSGDGPTCARQLSQDSVAAAGAEKPLKLYDRRRIFEAVAQNNCQELESLLCFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHSGQNDTIPLLLEIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTPDNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAAGSGKIGVLAYILQREILEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCERNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRVVKRIFYFNFFVYCLYMIIFTTAAYYRPVDGLPPYKLRNLPGDYFRVTGEILSVAGGVYFFFRGIQYFLQRRPSMKALFVDSYSEMLFFVQALFMLATVVLYFSHCKEYVATMVFSLALGWINMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNSSTSAESTSHRWRGFGCRSSDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKSIWKLQRAITILDTEKGFLKCMRKAFRSGKLLQVGYTPDGKDDCRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSGRVSGRNWKNFALVPLLRDASTRDRHPXPPEDVHLRPFVGSLKPGDAELFKDSVAAAEK
The following text describes a protein:
Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRILKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQLETVRENLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIESLITKKTVDRTIEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGSPPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVSGSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQEEALKGEATTATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEECFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKCFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGILKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSLKFYRGVKKKMKPPTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKDDKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVIEELNVVLQRSRTLPKELQDEQILK
The following text describes a protein:
Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Subcellular Localization:
Cytoplasm.
Sequence:
MGKLIMSIDQRLQLIMRNTAEVITIDELRKKLESDEKLKGYIGFEPSGLFHIGWLIWTQKVKDLVEAGINMTLLRAAWHAWINDKLGGDMNLIKMAADYAVEVIKNYGVDVGKLNIVDADDIVKEKDYWALVIKVAKNASLARIKRALTIMGRRAEEAEIDASKLIYPAMQVSDIFYLDLDIALGGTDQRKAHMLARDVAEKMGKKKIVSIHTPLLVGLQGGQRMNITEGMEEDDIQAEIKMSKSKPESAIFVNDSREDVERKIMGAYCPKGVAENNPILQILKYIIFPRYNFVKIERDIKYGGDVEFKDYEELERTYIEGKIHPMDLKKTTARKLNEILEPIRKSLEKKPEFEEMIQKISKSVTR
The following text describes a protein:
Function:
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Membrane.
Sequence:
MEFRADVIIACSAVVLISSLIYQLGWRLGLREVTKKTRKPRRRMKVNENNNGPEVIIVGSGILGSAMATVLARDGRKVTVIERDMKEPDRIVGELFQPGGRQALTELGLGDCASGFEEIRMDGFVIYDPITKEPIDFQYPKDKAGKIQPATCFHHGRFVMSLRKAAMAEENVTYIEGTVTTIVEEKGRIVGVEYKKKGQQEKEILRAPLTIVADGTFSKFRKQFSTASLDQMTKPTSYFIAFKLKESFDFKAHHAEGLWCHSTPTIVYRIAPDTLRLMFDIDTSVQPKNPKQFIMETIYPELPEHLKKMVGPAMENDSVRIRIVPTYYIPSAPVQKPGCLLLGDALNCRHPYTASGMTVAFKDVKCWADLLEGIESLGESISKG
The following text describes a protein:
Function:
Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.
Subcellular Localization:
Cytoplasmic vesicle.
Sequence:
MASSSILSLSFFFFFFFSLLVTLSHAATFEIVNRCSYTVWAAAVPGGGRQLNQGQSWTINVNAGTTGGRIWGRTGCSFDGSGRGRCQTGDCGGVLSCTAYGSPPNTLAEFALNQFNNLDFFDISLVDGFNVPMDFSPTSGGCRGIRCAADINGQCPGALKAPGGCNNPCTVFKTDQYCCNSGSCSPTDYSRFFKRNCPDAYSYPKDDQTSTFTCPGGTNYRVVFCP
The following text describes a protein:
Function:
Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney.
Miscellaneous:
MISCELLANEOUS: The role of Amn in embryonic development seems to be species specific. In mice, null mutations lead to embryonic lethality. Canine mutations give rise to much milder symptoms.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Endosome membrane. Membrane, coated pit; [Soluble protein amnionless]: Secreted.
Domain:
The complex formed by AMN and CUBN is composed of a 400 Angstrom long stem and a globular crown region. The stem region is probably formed by AMN and the CUBN N-terminal region, including the EGF-like domains. The crown is probably formed by the CUBN CUB domains.
Sequence:
MGALGRALLWLQLCALARAAYKLWVPTTDFEAAANWSQNRTPCAGAVVQFPADKAVSVVVRASHGFSDMLLPRDGEFVLASGAGFGAADAGRDPDCGAGAPALFLDPDRFSWHDPRLWRSGDAARGLFSVDAERVPCRHDDVVFPPDASFRVGLGPGARPARVRSVQVLGQTFTRDEDLAAFLASRAGRLRFHGPGALRVGPGACADPSGCVCGDAEVQPWICAALLQPLGGRCPPAACPDALRPEGQCCDLCGAIVSLTHGPTFDIERYRARLLRAFLPQYPGLQAAVSKVRRRPGPHTEVQVVLAETGPQPGGAGRLARALLADVAEHGEALGVLSATARESGAPVGDGSAAGPLGSGSRAGLAGGVAAGLLLLLLALAAGLLLLRRAPRLRWTKRERLVATPVEAPLGFSNPVFDVAGSVGPVPRTPQPPPAQQAGSSSTSRSYFVNPLFAEAEA
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MATLLSFSGSPVVVYHRTHPTSLSSLRHSCFLTLVNPKKKLRGSFRHNRPISAQSNGGNSADTPDRLISALCYFYPFFDGIQYGKYVITQFSPIQILLQPLVPAIRVFKSFPFNGFLVFLALYFVVVRNPNFSRCPDCRLSPKPLRGKSCDFPI
The following text describes a protein:
Function:
Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAQAPAPAPGPGPGPPGRLYYERLGRLQRGLRASEKKRLDLERKLYEYSQSEAYLAKLKYLKLKKYLDEICEAERRAQVRNEEYLKEFERLENHVRSFTASTEKLQKLKMECESQIRRMQLHSKNNPWMKDEPKENSQEQGLQVVRQAGINTGTAVSRGLYHRAEIFMGRQMSAISSLEDFSTRQKSSQPTKSFSIPDPHSCRQTAQSGNVTDSYVVQTNSDIVCSNKPDKIDGKTSLQMGEEMPVTSSISPEEVQTHCLEIESNTNNGKSNFPESKKPAELNSPVQKRLSPENSTTDLKCDSSSGSEETRGGTPSCACTEVKEVRTERSVPVAPSPVRRSSENEHAEGNRRAWESSLGHRVDANQRPFLNRPEQEEDIFSTSSNLTVSVSEDDSAPSVSELQPNLGDDVGGIGEELIHDGQEKDVPSAKNNNCDLQTLSSQASEKESSGNSPKREVCLSFRGFSHLLQFIEDQLEQANTKHVELYQTAALSPEKLTRLINLCNQTGILKEEDLEACGTVVLHQFQRLLECISPKCLLPEHDLIDRRNTMDEKPVRLEQPPDSVLFRERLSQHAYTLKKYKVSLQEDVAKMFETLLAAESNDQSPTATALLKKALTEECEDRSSIHSNDSSCSLPSILNDNSGIKQANHTQWLDSTGTKKQEVPSGCEDESKEESLEEKIPITETKAYQLLKLSTLQAGKDQTRGKNQKKKAGGSKSQVPGLDDGSKTFKTKTSNQIGSEAVFSSGEGSPLSREFVETGNIVQTLHLGIVILIRRIKIRKAKIDVTKSEHTSSDLFNFTITG
The following text describes a protein:
Function:
General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.
Subcellular Localization:
Nucleus.
Sequence:
MAGRSRCPECGSGEVVEDAHYAQTQVVCAQCGCVLTEGLLTTTFADEEHLREVTYSRSTGESEQVSRSQLRGLRRVKDLCRVLQLPATFEDTAISYYRRAFQHPALRAARIQKKEVLVGCCVLVTCRQHNWPLTMGTVCSLLYADLELFSAAYLQVVKLLGLDVPALSLADLVKTYCGSFKVSQASPSVPAKFAEDKEKLVSRTVQLVELASDTWLVTGRQPVPVITAAAYLAWQSLRPGGRLTCPLARFCQLAGVDLPHPAYLRLQELLAILLRMAGKLAWLRLLSPDKRTVVKHIGDLLQHRHLLIRRAFRERVEQDEEEDEEQEEREEEGPEEERRPQEEKGSDRPSVPQRGKRPASPPPLLPPCLLRPQKRPCPRPPDTHITGYEDISDSELEQYLRTHEEVKEFQKAQAASQKAVGTPDPS
The following text describes a protein:
Function:
Cell adhesion protein involved in target recognition during neuromuscular development. Mediates homophilic cellular adhesion.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MATLADSAICFLLLSLLLIGACLVTPTEGRAKDDRRTRGRGSSSGVLSSSSSSSNNMNNGYYSGSSSTAGSSSGYVFTSSSAVNSGSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHCTLQEPKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHKRYDYYDDNNGGMSLGHGLDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDILTTKNAIYIKLFLLKPEMLPCHDELSDPTELPLSRDLMDVRSNVGQDMSTAGANSLAQGMTIIVSLVALMMISRG
The following text describes a protein:
Function:
Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover.
Subcellular Localization:
Nucleus.
Sequence:
MCGESEDEFVKEEEVKREDVNEDEIKIEIKEKEGKRKIRVAVAGCVHGEIDKVYRTMEQLEKDGNGKFDLLLCCGDFQATRNYGDLHHMHVPDKYKSLETFYQYYSQAKKAPVLTVFIGGNHEASAFMCELPNGGWVAPNIYYMGNSNVLKYGGLRIGGLSGIYKGKDYHKGRFECPPFPSGSNISAYHVRSLDVFRCKQMSSMDIFLSHDWPTGIWDYGDKDWLLRKKVHFTEEVNAGTMGNPGARELLMKLRPQYWFSAHMHIGFPALVDHPKKEGEENEKVTRFLSLDKPLPRRHFLQSIDLWVDENADLSLSYDEEWLAILKNTDSLVCTTDKKAYLPSKMNKTERYDFTPTEEELAEIRSLKDDFHIPFNFQPTAPPLMKDDEEDKRAPPAFYYRNPQSTQFCSWLGIQDLNDIWANTSSTVATPHYELEISREGMNDVEQDREKFGEEDFIIDTGTEGEEEEGEEGMGVGDGNGLGDWIPPSIDSNEEKDEGEKTIEFKRRKVDFDPEE
The following text describes a protein:
Function:
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MCLLLAAHIAFVPAARMLFFMALACASPFLEFREESPRSLNVAIIFSGTSYPPESARFAPTTFRNFSMEVNPISVILNDTNPRSLILQICDVLSSLRIHGVVFEDDTRTESVAQILDFISAQTSMPIIGINGGSAIVLTPKEKGSTFLQLGASTEQQLQVIFEVLEEYDWTSFAVITTLFPGYEDFVDYIELLTDSSFIGWENRGVLTLNLTDDPSGSKLKRQLREITAQVRLLYCSREEADGVFKAAREAGLTGPGYIWFMVGTNLGGTDYMPEHLPVGLFTVLSAGWKDDLHRRVQNGVAIIAKGAEALYKDFGFIPEFNNDCRAPNLTHMNENLHRYFMNISWGGKDFSFNEDGYLINPALVVIALNKERSWEVVGIWEHGDLRMKYPVWSRYGKFLQPVDDDQHLTVATLEERPFVIVEGVDPATGTCIRDSVPCRKQLNRTDNHLTDPIIFVKQCCKGFCIDILKRLSKTIGFTYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYFSPVGYNRSLSTGKRPGGSKFTIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLIWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDKKFQRPHEQYPPLKFGTVPNGSTEKNIRSNYPDMHAYMIKYNQRHVEDALQNLKTGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALQKGSKWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLIYWKLRHCMRHSGKLDFLLAFSRGMYSCCSAEAALPNSSVPPPPLPSAPLPCSNFIPRERRVVERWRHARSPNCYKDIYTPTRSVHDPNNKAAPPRLPHKNAFSDGFHRYYGPIEPEGLSDHLVESGQAFGKDKKMASCQMSPQTQREHFLENPPSYFAIVREKDAPEPPGWQSKISRGLYENYQSGKERTPKSTAGARGSRTPETAAKKFDHLGSSYQSKGTCEIEREVYNSGGPSSSSNRPNKASVDLFDQPHYSGHTRFTYEDERSCGRDCHHRRDDMDLESQPLLHKKSSRSHMCRSHSHPLVMGASKSKYADLSDSDSDVCERDPPCVKTEMGHNCWYSPNYFCTYPSRERQASSAPHKPMRYWSVDKLGKYHQLSKEYLPGTCHGSCYCSSLEMLQPHCHKEPRYFSCSDEKLERRLDWEHFRSGHCSFLHHHHHSCDLAPIHPTSRSLEDLSRCHLRCHRHIFSPECQPRSSHSGTLYKRRGSAHFSSLESEV
The following text describes a protein:
Function:
Plays a role in cell cycle regulation and chromosome integrity. Activates DnaA-dependent chromosomal DNA replication initiation ensuring that the chromosome is replicated at the right time during the cell cycle (By similarity). May regulate replication initiation through phosphorylation of a possible second messenger or metabolite, and by interacting with replication initiation proteins. Has ATPase activity with D-ribose and 2-deoxy-D-ribose in vitro, but not with choline. Involved in DNA damage response.
Subcellular Localization:
Cytoplasm.
Sequence:
MNIDMNWLGQLLGSDWEIFPAGGATGDAYYAKHNGQQLFLKRNSSPFLAVLSAEGIVPKLVWTKRMENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDMLKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDVNHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESLRLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Sequence:
MLEITLLGTGSPIPDPDRAGPSTLVRAGAQAFLVDCGRGVLQRAAAVGVGAAGLSAVLLTHLHGDVLITSWVTNFAADPAPLPIIGPPGTAEVVEATLKAFGHDIGYRIAHHADLTTPPPIEVHEYTAGPAWDRDGVTIRVAPTDHRPVTPTIGFRIESDGASVVLAGDTVPCDSLDQLAAGADALVHTVIRKDIVTQIPQQRVKDICDYHSSVQEAAATANRAGVGTLVMTHYVPAIGPGQEEQWRALAATEFSGRIEVGNDLHRVEVHPRR
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFTVPGWNVSAPIAAQVEKPKPKDPNKLGKKALKRKEKQEQQVNAENIGELWDKVVDGKGSVVEEKPATATNGVEETGDGAQEKRGKKRKRGKSSKQKAEEAASRENDDSIATEKDASVKTPDVSAQKPANTDSEAKRDKKKRKKDNKAQANGDDAKPAGKGLIQSTDLTSLIPEPAGLTPLQRSMRAKLASARFRHLNESLYTKPSVDSLSLFKEDPSMFEDYHRGFAQQVEVWPSNPVDEYVESILARGKVRNRDPWKDAQRKAKGKGKGGKEPDKEPEVTAVGVRLTGNSKPLPRNHKHQATIADLGCGTASLSYRLQPHLNDLHLTLHSFDLSKPTGPSAPLVTVADIANLPLQDGSVDVAIFCLALMGTNWLDFIDEAYRILRWRGELWVSEIKSRFGRVERKKGGVPINSIGSLKKPDKKNKSKKGKDKPEEEGIVDSADESELAQVVDGVAGAEGTDVSAFVEVLRKRGFVLDALPEKQSDAIDLTNKMFVKMQFVKSAPAIKGKNAKEGAAAKAEGKFETSRAMKFGMKGKKLNAIAGDDEADDEKEMKVLKPCLYKIR