lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MCHSRSCHPTMTILQAPTPAPSTIPGPRRGSGPEIFTFDPLPEPAAAPAGRPSASRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILMAEEGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQQHPAAF
The following text describes a protein:
Function:
May have an important role in respiratory metabolism. Cryptosporidium have a relic mitochondrion with no function in energy metabolism so it is not known if PFOR has a function.
Miscellaneous:
MISCELLANEOUS: Arose from gene fusion of pyruvate:ferredoxin oxidoreductase and cytochrome-P450 reductase. Gene fusion has only been found in Euglena and Cryptosporidium.
Sequence:
MGEKEIVDGCVAACHIAYACSEVAFTYPITPSSTISEVADSWMSRGRRNIFDQVVSVVEMQSEMGSAGALHGSLSVGCSTTTFTASQGLLLMIPNMYKIAGELWPCVFHVTARAIATSSLSIFGDHNDIMAARQTGWAFLGAMTVQEVMDLALVSHVSTFECSVPFVNFFDGFRTSHELQKIDMISYETIKKIFPYEKLKEFRERALNPTHPTLRGTATSSDVYFQLAEARNKYYESTPDIVQSVMDRLAKLIGRSYHLFDYYGHPDAEFLIVVMGSGGLTIEEMIDYLMEKSNEKVGMIKVRLFRPWSIDAFVKKIPKTTKRITVLERCKESGSLGEPLCLDVSTSIMRSELSSNNILVLGGRYGLASKEFTPGMALAVWENMISENPINNFSVGIDDDVTFKSLFVRQPRLDLLTSETKQCLFWGLGSDGTVSANKNAIKIIGESTDLQVQGYFAYDAKKAGGATMSHLRFGPKPIKSAYLLQRCDYVAVHHPSYVHKFDVLENIKQGGCFVLNCPWSTLEELNHELPSKIKHQIASRDVKFYVIDAQRIAQESNLGRRINNILMVVFFSLTNIIPLDLAIKLVKEAIKKTYGKKGDAVVNSNWKAVDLTLESLIQISYDKSQWISKDKCGEKSLPATAVETGNKDQEITKSTVLKQKPEHDVNQFVKDILGPVNALKGDELPVSMFEPTGTVPLGTTAYEKRGIAMSIPIVDMNKCTQCNYCSIVCPHAAIRPFLLDEAEFKNAPETMHIPKAKGGQEFSSYYYRIQVTPLDCTGCELCVHACPDDALHMEGLQKMEAVEKTHWDYLIGLPNKAEKFDRTTVKGSQFQQPLLEFSAACEGCGETPYVKLLTQLFGERMVIANATGCSSIWGASYPSVPYTKNQKGYGPAWGNSLFEDNAEYGLGMVVGYRQRRDRFRELVSNEILKDITEEEEFLKDDNASVQGRNEIITKYDHLKDYLRSWLKNIRNGEACQSLFEEISKLLEDNLINSNNFAQVLKKDRIELLEKLYDSRDLIPKISHWIVGGDGWAYDIGYAGLDHVLSFGEDVNIIILDTEVYSNTGGQASKSTPFGAIAKFAQSGNLRQKKDIGSIAMEYGSVYVASVALGANYSQTIKSLLEAEKYPGTSLIVAYSTCIEHGYTKYNLQQESVKLAVESGYWPLYRYNPELVRTEVVDNLTTIVSSGFTLDSKKVKVDIENFLKRENRFLQLIRSNPELASMAKDKLKAHSDKRFQKMKDMSENVTVTALKDQIKKLKDQLISIQNASKTGELAASGLINADLFIEQEMHVLYGTETGNSEEVAQYIQSQLVSRGYSSSSLNLDDLDIDEFLNPDKFSTVIIVTSTSGQGEFPGSSGILYEALLKKHLENQDDKFCSFMRFGIFGLGDSNYVFFNEAAKKWDKLLLDCGAVRIGAVGMGDDQSEEKYETELIEWLPDYLQLINAPEPKHDEKSEIPKATTFKVTILDSCRNDILNESTGTLCEKLDENNNIGNSHYKPIIPPNSVLLPVIENKRITNQDYDKDVRHIVFKLIGDGGDTPSLSYCLGDSLALYGQNPVNEAIKAIEMFGYNPYSLLRLSINEENEANNTNKVNQRYSSLFGYDITVLQLFVECLDLWGKPNRKFFQEFYRYCSNPEEKIQAKKWAQNEGKKLIEEFSSKTGTYLDVFKMFESARPTLAQLLDIVPFIKSRSYSIASCNKFVNGEKIELCVGIVDWKLESGEIRYGQCTGFLNRLPILDSESKIDSIPRLPSNIKASAFNLPFDYRSPVIMACMGTGIAPFRAFVQNKKYIRDVLKEEIGPVILYFGCRYYDNDYLYREELENYVKEGVITSLNIAFSRDPKGYKTSNCENIRYAQKMYVQHLMLENSQEIYENMIEKCGYFYLCGTKQVPIDIRKAIIQIIIKHSSTTEQVTSEEDANSILNSIQIMGRYNVEAWS
The following text describes a protein:
Function:
Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNLVGSYAHHHHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADSAPDFPAGGPPPTAAAAAASYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQAGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPGEKRIKGRTGWPQQVWALELNQ
The following text describes a protein:
Function:
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MEPSEEPSHISKDNFLEVPNLSDSLSEDEEIKANFRPGFSPQPSRRGSDSSEDIYLDTPPPSGARRVSFADTFGFNLVSVKEFDSWELPSSSTDFDLTKDIFHTEEYVLTPLFDLPSSKEDLMQQLQVQKAILESAEYPPGSTSMKGIIRVLNISFEKLVYVRMSLDDWQTYYDILAEYVPNSCDGDTDQFSFKISLVPPYQKDGSKVEFCIRYETSVGTFWSNNNGTNYILVCQKKEQEMEPVKPQEDVPNRHIKGCLKVKSSKEESSVPSEENNFENSKITDTYIPTIVCSDEDKEDLETGNQNVKDVNREHDEHNEKELELMINQHLIRSTASRDEKNIVNFPNKAEGLEKKEIHDEVFTDLFKRPLSSSSSAERSLKGDSYPNEQYPSGNEGSHQPSEGISSDMGEIKPSLGNTSSDELVQLHIGSKEVLDDNANPAQGRGRVKISHLFSDQIMAENCNKKLEEEAKKIEMKDWECLRRDFHSEFHSEESTEKGSSKKDYDSGKNEEEEQRIHLGVNEKQRKKFPSTLHDQERKTGHSEISVEGMGASTRDLTALPSKDTTIHGQAIRADIFHSPRTNLSWEEAVLTTPDCDLSTREGISLGGILGQACSPRNGNVLRNKHLFQAEEEQSDCIKPEDQHKNTQHKQNQNVLESQGKARENRTNITEQTKEQADCEDMWKKRDNTRILKATPTEKLFTCQETASYELSSLADHGITEKVEAGTAYIIKTTSESTLESMSAREKAIIAKLPQETARSDRPIEVKETAFDPHEGRNDSRDNLCQRDTVGVTYDNDFEKESCLGICNVHIDETEKEETISVYNSGKTHDRKKRDVGNTTSVEESSQGIIDNQKADSKLDLHLEMLPIGKKIFTENKDPGQVQELSKKTNIDAVIHSALNSGTNGASQNGSHVSNHHAKNSVPTHEQEAAAENENTTTTPQSISSKSEYNCNPTREIQGIDKHPHPMTTPEDVSKSSGIVTSGSWKERCTGQISQQGECSVETSLGPTILTSEALENKEEARHENEGLINSGQSLCSSGDKESESSASSSLPAQESQAQSSESLLSKYINSKIPYFLLFLIFLVTVYQYDLMIGWAF
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MKKVKKEKVIGPVVPVSYNRSILAAFEKQAKGKTCPLCNIKFSLASYRSHMNVCKVADDDDEIKVMASYTREEAILLRAGPEIVLGEENSGQEIPVNPKKKRRTGEEQLESTPNPPVVQAFDFDVPGPSTSSENLDPPSESSEVRSVEKEIKKSPVWENRRRSTRLAQNSQKSQSESQEAIVKKETATVLEVLASINNFETRIANSDRPTPYYVKCTVKILKKIISTMKSDGDFYADNFWLPSDIITFYRFVECLSDGAKCLLVRLFVRKPNWYHLEKLEQKYTEILNIRGAAVELMKWEFISDDSTLKTLNEALRISDITVLKNVAKKFKIDGNKNRQDLVQSLRKFALSQQSIFGGTGSVELAVLKSLKTELGTCIKIKDEMVDLFKCLFTLYCPVTTNSANVIDNPASTNVYQDLLYMMLSVENGSVEFPAPNPCPNIASFYKNRAMLMEYVTAKALESSLVLQMSNGDHDIALDLAIDAKEFLDQMPLEQKKYYESLEIHERKFTSIWVHTRCCGHATSVLEKQKKYGMAVEWQKDLLITNKDVQSCCLDSRGMWWDRMLLNLDSHLKVSVFPSYSQTKKRFFQEKTECAKMIQIALTDSSILEKELLSIQDRALKLKEMPPDFRPPLNIGTPMKRVITARTISKSLGDGRVNRFVFRDEEKEEDVECSVEEAARRWYIENDEFTTGVHDEGATWHTLFGLLFYDIIFCTDAVMASVWHSEVQDCPSDLSNTLYLKRKEKFEERFEWLKDADQETIEDNIRRIWGMKQNETNRECSWKHFQSGIEDCVSIFQCIPRPAMLSIFRRLAENYRNSRSGFPDLTLWNPEKKTVAVIEVKGPGDRLSTKQRLWLSFFADNGIKAEVCHVEAQNSRLLV
The following text describes a protein:
Function:
Possesses antifungal activity against P.infestans but not F.graminearum.
Miscellaneous:
MISCELLANEOUS: Antimicrobial activity is not affected by salt concentration.
Subcellular Localization:
Secreted.
Sequence:
DRQIDMEEQQLEKLNKQDRXPGLRYAAKQQMXTXRMG
The following text describes a protein:
Function:
Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.
Subcellular Localization:
Vacuole. Secreted.
Sequence:
MSQSHSILSSLILLVAIIFCVPHVIAVPWTTDGHAQLSPVTPRYPTQEPSGIRYRNVIPQLTWLCDTAIEKIFGLPPKVAKKPDVPGNVARPTNAQLPATLLAKYGGDVVLRFNLTTPAEEQALAEAADTLFLDIWEFTSNWADIRLREDDVPSLLGLLPKSLQNAYSHLMPDLAKSIYQSYPSMAYADAAFSSKHVERAFTPALRTSKVEGADNIFFQNYQPLSVIIPWMRLMSSMFSTHVRMINIGISYEGRDIPALRIGVSPNLPSEATKPRKTIILSGGFHAREWISVSSVTYAAWSLITSYGKSPAITKLLQEFDFVLVPTINVDGYVYTWENDRLWRKNRQQTNLRFCRGLDLDRGFGFEWGSSTQTNPCSESYPGDAPFQAVESHRFAEWAKNETENNNVHFVGFLDLHSYSQQVLYPYSYSCLADPPSLENLEELGIGLAKAIRISSGEQYTVASACEGAISSKIPGYSSTSRMEMGGGSAIDWFYHELGVRYSYQIKLRDTGSYGFLLPKENIVPTGEEVFNVIKYFGDFLLGDKGIEKAKSSEEEPITKPVKSELPLGVMEEESVISDEIEDEYEDINLELKRRRR
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
LDLIKNVEVQAIIGPQTSAQAQFLSELANKSQIPVISFSATSPSLSSTHTPYFVRAIPNDSIQAKPIASLIKFYKWRRAIVVYEDTDYRAGFIPYLTDALSEIGSRLQRRTLLPSVASDELIRKELYKVMTMQTRVFVVHMSSPLASRFFRQVKQLGMMSRDYAWIITDGLTNLLNSMDPWTKDSMQGVLGVRAYIEGTQRLDKFSTRWKRYYRKEYPNEIDIPHFNVFCLRAYDATRVLALAVEKSGAGTENIGFLRGTAGQMAGNSTDLSTLGISPAGPRLLSAILDTKLKGLTGTIRFVNGEIQGSTFQIVNVVGKCEREIGFWSTGTGISREFSRKKVDKRRDDEANLGPVIWPGESTVTPKGWVVPTDGPKLKVGVPVRKGFEEFVKVERLDGRPTTTGFSVDVFDAVVKALPYRLEYEFLPFFIYSNSTSFLPFGDDNKSEAGTYNDLVYQVFLGKYDAVVGDVTIEANRWRYVDFTPPYTDTGMSMIVPMREERVSRALTFLKPFTWELGMTTACFFFFMAFVVWVLEHRINEDFRGPPSEQIGRALYFSFSTLVFAHRDKITSNLTRFVVILWLFVVLILTNSYTANLASILTVEQLQPTVTDVQTLIDKGDYVGHQGSYFIEDFLKKLGFAGSKLKVFDTAEEYAEALSKGSSHGGVAAIFDEIPYIKSFLLNRTKDFMMAGPTYRTGGFGFVFPKNSPLFSDISSAVLNVTGGERMDLLERKWFPQRNTNSPSSKGLNLDRFWGLFLIVGTASMGTLIIFFMGFCNEHWNRTATETTPMNKGFWPRIVAMAKHYDETDLSSHTFRRKQRKEGETEENRDVSLAPSVTENPLSSHAKTERLSIEDGSPHHSNSVSADGDDDDAPIQERHAPTP
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
Subcellular Localization:
Nucleus.
Sequence:
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDETHYKELLARHVSPPPASSGSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDNNSTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYKGERFCYGCQGELKDQHVYVCTVCRNVFCVDCDVFVHDSLHCCPGCVHKIPTQSGV
The following text describes a protein:
Function:
Involved in plants secondary metabolism. Functions as acyltransferase to form the sinapate ester sinapoylmalate. Also capable of catalyzing the formation of 1,2-bis-O-sinapoyl beta-D-glucoside.
Miscellaneous:
MISCELLANEOUS: In cv. Pna-10, this protein SCP8 and the adjacent SCP10 are not present due to a natural 13-kb deletion; MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site.
Subcellular Localization:
Vacuole.
Sequence:
MSLKIKFLLLLVLYHHVDSASIVKFLPGFEGPLPFELETGYIGIGEDENVQFFYYFIKSENNPKEDPLLIWLNGGPGCSCLGGIIFENGPVGLKFEVFNGSAPSLFSTTYSWTKMANIIFLDQPVGSGFSYSKTPIDKTGDISEVKRTHEFLQKWLSRHPQYFSNPLYVVGDSYSGMIVPALVQEISQGNYICCEPPINLQGYMLGNPVTYMDFEQNFRIPYAYGMGLISDEIYEPMKRICNGNYYNVDPSNTQCLKLTEEYHKCTAKINIHHILTPDCDVTNVTSPDCYYYPYHLIECWANDESVREALHIEKGSKGKWARCNRTIPYNHDIVSSIPYHMNNSISGYRSLIYSGDHDIAVPFLATQAWIRSLNYSPIHNWRPWMINNQIAGYTRAYSNKMTFATIKGGGHTAEYRPNETFIMFQRWISGQPL
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKFSAQTWRNSVPNLLLWLPLIISLLLFQCLANSSQTTTSVGVIIDVNSEIGKNQKTAMQIAAQSFNNYSNNHNIILFFRDSGKNPLQAASAAEDLITKEKVKVIIGMETWQEAAIVADFGAKFQIPTISFSSPPLVSSSSMQFRWPFLIQMAQNHSAQMNFLADIVHGFNSQKVIAIYEDNPYSSDFGMLNLLSEALEKVNSKIEYRLVLPPFTSLSDPKGFVLDELLKLLRLKSRVFIVLQASLPMVNHLFREAKKIGLLEKESTWIINEEITSMLDSVDTSVLSSMEGVMGIQINYSTSSSAYTQLQENFQDEHTETVESKPGSNTLLAYDGISVFTKALEKMNTNFSSSKTLLEEMLSSNFNGLSGNIKFKERQLSYTPMLEVFKVMNNAKKHFEFDSWTPNLKFSRSLKESTSDGTTETKTWKVPTDANPLKVALPTNPAFDNFLKFSQNQPPTGFCIQLFKDIREILSDQYSDLPYEFYYDFNGSYDALLDKVIDESYDAIVGDVTILANRSKNVSFTQPYTESGLSLILPAESDDSAWLFMKPFSTEMWITTVGILIYTMIIIWFLEHHLNPEFGGTVKTQISTTMWFAFTSLFFAHKEKISTNSARVVVGVWLFLVFVITSSYTANLSSLLTVQKLKSARDIEWLIQNKLPVGCDNSSTFVKNYLVQVYNFPRQQVVDVDNEQDIVEKFKSKQISALFIESPYEKVFLNKYCKDYTATTAAYKFGGMGFVFQKGAPIARDFSEAILTLAENGNLKHLEETWLTPSTECSTNSASPETESLTLAKFLGLYIICAATSTICILLALLRKYFHNHNHYDEQAQLPQGNVIAESDDENNNNDMKRSIRNGTGLYNGNLIMTLNKAASFGGSVLQGIRHRNSPRQENVSDSDEPINPQRSQSAVIEMI
The following text describes a protein:
Function:
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Associated with CD177-negative phenotype; MISCELLANEOUS: [Isoform 3]: Associated with CD177-negative phenotype.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-like-anchor. Secreted. Cytoplasmic granule membrane. Cell projection, lamellipodium. Note=Cell surface expression on neutrophils is increased upon TNF-alpha, fMLP or CXCL8/IL8-mediated stimulation. In neutrophils, stored predominantly in secondary and tertiary granules. Can also be shedded from the cell membrane. Localizes to lamellar protrusions in spreading neutrophils.
Sequence:
MSAVLLLALLGFILPLPGVQALLCQFGTVQHVWKVSDLPRQWTPKNTSCDSGLGCQDTLMLIESGPQVSLVLSKGCTEAKDQEPRVTEHRMGPGLSLISYTFVCRQEDFCNNLVNSLPLWAPQPPADPGSLRCPVCLSMEGCLEGTTEEICPKGTTHCYDGLLRLRGGGIFSNLRVQGCMPQPGCNLLNGTQEIGPVGMTENCNRKDFLTCHRGTTIMTHGNLAQEPTDWTTSNTEMCEVGQVCQETLLLLDVGLTSTLVGTKGCSTVGAQNSQKTTIHSAPPGVLVASYTHFCSSDLCNSASSSSVLLNSLPPQAAPVPGDRQCPTCVQPLGTCSSGSPRMTCPRGATHCYDGYIHLSGGGLSTKMSIQGCVAQPSSFLLNHTRQIGIFSAREKRDVQPPASQHEGGGAEGLESLTWGVGLALAPALWWGVVCPSC
The following text describes a protein:
Function:
An redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by a cognate anti-sigma factor. RshA and some peptides derived from it inhibit the sigma factor activity of SigH. Probably releases SigH during oxidative stress.
Sequence:
MSENCGPTDAHADHDDSHGGMGCAEVIAEVWTLLDGECTPETRERLRRHLEACPGCLRHYGLEERIKALIGTKCRGDRAPEGLRERLRLEIRRTTIIRGGP
The following text describes a protein:
Function:
Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger. Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus. The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries. Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels. Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MSLRQRLAQLVGRLQDPQKVARFQRLCGVEAPPRRSADRREDEKAEAPLAGDPRLRGRQPGAPGGPQPPGSDRNQCPAKPDGGGAPNGVRNGLAAELGPASPRRAGALRRNSLTGEEGQLARVSNWPLYCLFCFGTELGNELFYILFFPFWIWNLDPLVGRRLVVIWVLVMYLGQCTKDIIRWPRPASPPVVKLEVFYNSEYSMPSTHAMSGTAIPISMVLLTYGRWQYPLIYGLILIPCWCSLVCLSRIYMGMHSILDIIAGFLYTILILAVFYPFVDLIDNFNQTHKYAPFIIIGLHLALGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHVTYNMGLVLDPSLDTLPLAGPPITVTLFGKAILRILIGMVFVLIIRDVMKKITIPLACKIFNIPCDDIRKARQHMEVELPYRYITYGMVGFSITFFVPYIFFFIGIS
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Zona pellucida. Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MVSLSLQGEGRASAAGKTVTVQCHEATVDITVSADLYGIGTPVRAEELRLGPLSAGGSCGAAAAGSGGSFLIRANLSDCGTALSFVGEMLIYTNQLFYTPAPSPGGIIRMNGAAIPIECRYARRYNVSSNALKPTWVPFTSTKSAEDVLDFTLTLMNDDWSSKRSSNVFYLGDVLNIEASVTQANHQPLRLFVDSCVATLVPDQTSTPSYFFIENYGCLTDARVTGSSSQFMPRSVDTKLQMKLDAFRFHRDPRSSIYITCRLKVAPVSQVDMKNKACSYTGGSVSPRWKSADGSDQVCGCCDSSCGSGFKSRASLRWKRGDLSSTTWLDWKSDATVGPLVVLDGMQDPFYFNDHFKPRSSPSPALSAEVVMLAGVVAAVRLVCMAVLGTALYRRQSKSMA
The following text describes a protein:
Function:
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced; Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
Subcellular Localization:
Virion. Host nucleus.
Sequence:
MDPNTVSSFQDILLRMSKMQLESSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNEKWREQLGQKFEEIRWLIEEVRHKLKITENSFEQITFMQALHLLLEVEQEIRTFSFQLI
The following text describes a protein:
Function:
Involved in biological aging and stress response. Essential for adult survival (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKTLFVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVASHIRGCVCKLKPCVRFCCPHDHIMDNGVCNDNMSEEELTELDPFLNVTLDDGSVSRRHFKNELIVQWDLPMPCDGMFYLDNREEQDQYTLFENGTFFRHFDRVTLSKREYCLQHLTFADGNATSIRIAPHNCLIVPSITGQTVVMITSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLFDLWQISISFCKPAGVLGYFFVMAAFLWLSVISLHLWNTFRGSSHKASRFFSEHRFLAYNTYAWGMSMVLTGITVLADNVVEDQDWNPRVGEEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTARRIIGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYISQSNQTWANVFLVADYLNWSQGIIIFILFILKRSTLRLLQESIRGEGEEVDNSEEEISLENTRFDRNVLS
The following text describes a protein:
Function:
Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Translocates from the cytoplasm into the nucleus and the translocation is dependent on SOHLH1 expression.
Sequence:
MASSIICQEHCQISGQAKIDILLVGDVTVGYLADTVQKLFANIAEVTITISDTKEAAALLDDCIFNMVLLKVPSSLSAEELEAIKLIRFGKKKNTHSLFVFIIPENFKGCISGHGMDIALTEPLTMEKMSNVVKYWTTCPSNTVKTENATGPEELGLPLQRSYSEHLGYFPTDLFACSESLRNGNGLELNASLSEFEKNKKISLLHSSKEKLRRERIKYCCEQLRTLLPYVKGRKNDAASVLEATVDYVKYIREKISPAVMAQITEALQSNMRFCKKQQTPIELSLPGTVMAQRENSVMSTYSPERGLQFLTNTCWNGCSTPDAESSLDEAVRVPSSSASENAIGDPYKTHISSAALSLNSLHTVRYYSKVTPSYDATAVTNQNISIHLPSAMPPVSKLLPRHCTSGLGQTCTTHPNCLQQFWAY
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDIQRFLKFYKVGWKTYRDPLMEASHSSIYYWREQMKAMALFTTTEERLLPYRSKWHTLVYIQMVIFFASMSFGLTESMGDHVQMGRDLAFILGAFFIIFKTYYFCWYGDELDQVISDLDALHPWAQKGPNPVEYQTGKRWYFVMAFFLATSWSFFLCILLLLLITSPMWVHQQNLPFHAAFPFQWHEKSLHPISHAIIYLFQSYFAVYCLTWLLCIEGLSICIYAEITFGIEVLCLELRQIHRHNYGLQELRMETNRLVKLHQKIVEILDRTNDVFHGTLIMQMGVNFSLVSLSVLEAVEARKDPKVVAQFAVLMLLALGHLSMWSYCGDQLSQKSLQISEAAYEAYDPTKGSKDVYRDLCVIIRRGQDPLIMRASPFPSFNLINYSAILNQCYGILTFLLKTLD
The following text describes a protein:
Function:
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLNPRDVVIVDFGRTPMGRSKGGMHRNTRAETMSAHLISKLLERNPKVDPAEVEDVIWGCVNQTLEQGWNIARMASLMTQIPHTSAAQTVSRLCGSSMSALHTAAQAIQTGNGDVFVIGGVEHMGHVGMMHGVDPNPHLSLYAAKASGMMGLTAEMLGKMHGISREAQDKFGARSHQLAWKATQEGKFKDEIIPMEGYDENGFLKVFDFDETIRPETTVETLAELKPAFNPKGGTVTAGTSSQITDGASCMIVMSAQRAQDLGIQPMAVIRSMAVAGVDPAIMGYGPVPSTNKALKRAGLTIADIDFVELNEAFAAQALPVLKDLKLLDKMDEKVNLHGGAIALGHPFGCSGARISGTLLNVMKQNGGTLGVSTMCVGLGQGITTVFERI