lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSVQIMNYYGKGKIRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKGAIILRISAGINPFNVGEQQLLDIEDCDLNVVRCVFMFFLPDEDGNFTTALPPIVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEARGVFSQADVHRQVAIVFKTPPYCKAILEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDAYGNKSKKQKTTLIFQKLLQDCGHFTEKPRTAPLGSTGEGRFIKKESNLFSHGTVLPEMPRSSGVPGQAEPYYSSCGSISSGLPHHPPAIPSVAHQPTSWPPVTHPTSHPVSTNTLSTFSAGTLSSNSQGILPFLEGPGVSDLSASNSCLYNPDDLARMETPSMSPTDLYSISDVNMLSTRPLSVMAPSTDGMGDTDNPRLVSINLENPSCNARLGPRDLRQLHQMSPASLSAGTSSSSVFVSQSDAFDRSNFSCVDNGLMNEPGLSDDANNPTFVQSSHYSVNTLQSEQLSDPFTYGFFKI
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MSDGNSADDVGCWLTSKCSIVTTFFVVLLFVYYRYATWTHDTFKKLGIRGPKPWPGLGNFVSLYRTGMLKYDVEMKKKYGSIYGVFFGKQPFMVVYDTAILKQIMVKDFQYFPNHFDMGLLPPPMDKALSLLKDDHWKFVRSVVSPTFSSGKMRKMSGQINKCCQTLCENLSKEAESKKIFDFKIICDAFTMDTIASTAFGVSIDSHNDPNNIFVLMARKVFKVKMTLGGILLLVAPFLVKPLMRLGVPMFERDFIEFFTDVAKKAISQKDSADDKRHLDFLQILLNAHKENARDEDGLSEEEILAQCLLFFLVGFETTSTTLSYFGYNMACNPDQQEKLYEEIVEKIGDKEPTYDSILQLSFLDMCLNETLRMFPIGVRLETDRQATEDVTINGVLIPKGMVVLIPIYAIHNDPEFWPEPHVFKPERFSPENWNPSTSDPLRFMPFGAGPRNCVGMRLAKMEVKMAVIHMIRNFRFVVSEETDVPPVFERFTIKNINGIKIRVERR
The following text describes a protein:
Function:
Protein transport. Probably involved in vesicular traffic.
Subcellular Localization:
Endomembrane system; Lipid-anchor.
Sequence:
MATIGHNNLNAKLVLLGDMGAGKSSLVLRFVKGQFLEFQESTIGAAFFSQTLAVNDATVKFEIWDTAGQERYHSLAPMYYRGAAAAIIVYDITSADSFTRAKKWVQELQKQGNPNMVMALAGNKADLEDKRKVTAEEARVYAEENGLFFMETSAKTAANVNDVFHEIAKRLPRAQPTQNPAGMVLVDRPAEGARAASCCS
The following text describes a protein:
Function:
Probable leucine-rich repeat receptor-like protein kinase.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MNSSHTAFVAASFFFLLLAATAVLVSADLASDEQALLNFAASVPHPPKLNWNKNLSLCSSWIGITCDESNPTSRVVAVRLPGVGLYGSIPPATLGKLDALKVLSLRSNSLFGTLPSDILSLPSLEYLYLQHNNFSGELTTNSLPSISKQLVVLDLSYNSLSGNIPSGLRNLSQITVLYLQNNSFDGPIDSLDLPSVKVVNLSYNNLSGPIPEHLKKSPEYSFIGNSLLCGPPLNACSGGAISPSSNLPRPLTENLHPVRRRQSKAYIIAIVVGCSVAVLFLGIVFLVCLVKKTKKEEGGGEGVRTQMGGVNSKKPQDFGSGVQDPEKNKLFFFERCNHNFDLEDLLKASAEVLGKGSFGTAYKAVLEDTTAVVVKRLREVVASKKEFEQQMEIVGKINQHSNFVPLLAYYYSKDEKLLVYKYMTKGSLFGIMHGNRGDRGVDWETRMKIATGTSKAISYLHSLKFVHGDIKSSNILLTEDLEPCLSDTSLVTLFNLPTHTPRTIGYNAPEVIETRRVSQRSDVYSFGVVILEMLTGKTPLTQPGLEDERVVIDLPRWVRSVVREEWTAEVFDVELLKFQNIEEEMVQMLQLALACVARNPESRPKMEEVARMIEDVRRLDQSQQLQQNRTSSEATSNVSE
The following text describes a protein:
Function:
Amino acid transporter with broad substrate specificity. Can transport various amino acids, including phenylalanine, tyrosine, tryptophan, L-threonine, L-methionine, L-lysine, L-glutamate, L-valine and L-isoleucine. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTRQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGFPRIRQIPKGYLLAGSLLFVSYEICLALSLGYAATHHQAIEVGMVNYLWPSLTILFAILFNGQKTNWLIVPGLLLALVGVCWVLGGDNGLHYDEIINNITTSPLSYFLAFIGAFIWAAYCTVTNKYARGFNGITVFVLLTGASLWVYYFLTPQPEMIFSTPVMIKLISAAFTLGFAYAAWNVGILHGNVTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQGALMVCGGSLLCWLATRRG
The following text describes a protein:
Function:
Mediates influx of magnesium ions.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIKAYLRAEDTFRPVAVESDELAELDTDTLVWLDLMSPTTEELATVERCLKLELPTRQESEEIEFSSRYWEDETGIDINTYFLVKQDDKYHNETVSFILKRHFIVTIRFSDHRIFTEFSRRLRLNPRAFRDGADILNGILAMRVDMDADILEALSKSIASIGRKEPQSFDNPTTFLEYITDYEDINITIRENLTDKHRVLSSLLKSTMISEPLKKEFSMMMKDVNSLIISANFNFERLDYLQNLFLNHMSVEQNKVIKIFTVMSVIFLPPTMIASIYGMNYKHMPELEWVFGYPFALSLIVLSAVLPLYIFKKKGWL
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MVAKVYGVAASPYVATVLVCLEEAGASYELVAVDMAAGENRSRHHLARSPFGKIPAFEDGEVTLFESRAIQRYVLRNYNKPDLLREGNLEESAMVDMWMEVEAHHYDPAIFHIIRECVIKPMIGGGARDQAIVDENVEKLRKVLEVYERRLSESEYLAGDFVSVADLNHFPYTYYLMTTEYATLVESCTNVKAVEIMGI
The following text describes a protein:
Function:
Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.
Subcellular Localization:
Nucleus.
Sequence:
MMVARTRSQKRKLEEINNQKKIKTKKKATGQQTSNTKNLRDVKKKGKQLAYVPRTSPRKSYKNGEYVLAKMSSFPWWPARVASQKSIPTEVRERLKRNFRMDNGIFVQFLPSRDYAIISSSNVLPLTVDESRFILDHDLSTKYIQKTVGLIIASVKRKVSFSDVEEDEFEPENTRKKLQKPIEKPKKEKIEATPKIDGGKRLKNEKSSAEISQTSKQRPSRRSARVRMATDNAQKSPSPIPSPKKTAKKRVRFAGSLEELPKFSLEYQLAQPISTVDMYAQVHYIRFNTLLYYRYQLQEILLSYNHYPQESDMSHVHQILEMIENFSAINSELLESTKLYSLFTLLVKLSDIPLDEKYDFSSRFSTLLLQFQAFVQPKTMTSNVSTAPIGKNAQVNTEAARPSVITT
The following text describes a protein:
Function:
Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide.
Miscellaneous:
MISCELLANEOUS: The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth.
Subcellular Localization:
Periplasm.
Sequence:
MKKALQVAMFSLFTVIGFNAQANEHHHETMSEAQPQVISATGVVKGIDLESKKITIHHDPIAAVNWPEMTMRFTITPQTKMSEIKTGDKVAFNFVQQGNLSLLQDIKVSQ
The following text describes a protein:
Function:
Calcium-binding protein that is required for polar bud growth and cell wall abscission. Can also bind zinc ions.
Miscellaneous:
MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Bud tip. Bud neck. Note=Accumulates at the site of bud emergence in G1 cells. In small budded G1 cells, localizes asymmetrically on the tip of the daughter cell and in the nucleus. At a later stage of the G1 phase, is found at the emerging bud cortex and localizes in the nucleus. In large budded G2/M cells, localizes preferentially at the bud neck between the dividing mother and daughter cells, with very weak signals in the nucleus.
Domain:
Binds calcium via its EF-hands.
Sequence:
MCAKKLKYAAGDDFVRYATPKEAMEETRREFEKEKQRQQQIKVTQAQTPNTRVHSAPIPLQTQYNKNRAENGHHSYGSPQSYSPRHTKTPVDPRYNVIAQKPAGRPIPPAPTHYNNLNTSAQRIASSPPPLIHNQAVPAQLLKKVAPASFDSREDVRDMQVATQLFHNHDVKGKNRLTAEELQNLLQNDDNSHFCISSVDALINLFGASRFGTVNQAEFIALYKRVKSWRKVYVDNDINGSLTISVSEFHNSLQELGYLIPFEVSEKTFDQYAEFINRNGTGKELKFDKFVEALVWLMRLTKLFRKFDTNQEGIATIQYKDFIDATLYLGRFLPH
The following text describes a protein:
Function:
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Sequence:
MQRPDYRSSRRERAVRVYTICDESRYLIVKNVPALGCVDELVKLFGLYGPIEEYRTLDEEDCEPFTDVYWIKYSKLGNATFAKRKLDDYKFLGNLLEVSYAPQYETLSDTRDKLEERRRTVLNRIRVNAGGQHQAHRPFPTKRSLAEPHDPLLIHSGDQAEGSGRYAPLLLEPSSRSRTEDTGYNLEGRELVCRPEVEDVANVEYFSSPSMTATVRKVRETLAKIEATSLPQIRTGTSEDDSSVPTQRIEAERSVPDESSSLLKKRRQDSRRRI
The following text describes a protein:
Function:
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity).
Sequence:
MQGFKIARHFELPTAPSQFFAGSSLNRLSFLRSNREFLNKAFYDHTTRFLPFCDLNPALLVKDDKLVTLSYPQISKYFTFSPFEHTDKQIAERFSKGESLPVLVYMGNEERNGPTDNWSQHNVFAIDITGIDELQQSIRDNGGTFVNLRSIFTEQYQLSASDSGACAFARSILDWISRYRFCPGCGKRNIPTMGGTKLVCSDVLLNDDSNCPSKKGINNYQYPRTDPCVIMVILSHDMQHILLGRALRHPKGLYACLAGFLEPGESLEEAVVRETYEESGVDVEKVLYYASQPWPFPQSLMLACFGIARKNAKIQRDKDLELEDVRFFSREEVLRSLEWDAKDGPAPILFPPKLSIARNLIQAFAYDDWTNSQVKM
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport.
Miscellaneous:
MISCELLANEOUS: Maltose uptake in B.subtilis occurs only via the malP-encoded specific PTS-dependent EIICB(Mal) and not via another transport mechanism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site; The PTS EIIB type-1 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain.
Sequence:
MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADPDGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVSAILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKKLPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIYTFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGFALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFISPFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGLSFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADDTAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQVIIGLSVPQMRERVEKILNQ
The following text describes a protein:
Function:
Could be involved in the negative regulation of root growth.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MATTPVQPPVSNSPPVTSPPPPLNNATSPATPPPVTSPLPPSAPPPNRAPPPPPPVTTSPPPVANGAPPPPLPKPPESSSPPPQPVIPSPPPSTSPPPQPVIPSPPPSASPPPALVPPLPSSPPPPASVPPPRPSPSPPILVRSPPPSVRPIQSPPPPPSDRPTQSPPPPSPPSPPSERPTQSPPSPPSERPTQSPPPPSPPSPPSDRPSQSPPPPPEDTKPQPPRRSPNSPPPTFSSPPRSPPEILVPGSNNPSQNNPTLRPPLDAPNSTNNSGIGTGAVVGISVAVALVVFTLFGIFVWCLRKREKRLSAVSGGDVTPSPMSSTARSDSAFFRMQSSAPVGASKRSGSYQSQSGGLGNSKALFSYEELVKATNGFSQENLLGEGGFGCVYKGILPDGRVVAVKQLKIGGGQGDREFKAEVETLSRIHHRHLVSIVGHCISGDRRLLIYDYVSNNDLYFHLHGEKSVLDWATRVKIAAGAARGLAYLHEDCHPRIIHRDIKSSNILLEDNFDARVSDFGLARLALDCNTHITTRVIGTFGYMAPEYASSGKLTEKSDVFSFGVVLLELITGRKPVDTSQPLGDESLVEWARPLISHAIETEEFDSLADPKLGGNYVESEMFRMIEAAGACVRHLATKRPRMGQIVRAFESLAAEDLTNGMRLGESEVFNSAQQSAEIRLFRRMAFGSQNYSTDFFSHSSYNSRDANV
The following text describes a protein:
Function:
Postsynaptic scaffolding protein at the Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
Miscellaneous:
MISCELLANEOUS: Isoform 1 shows a punctate distribution throughout the cytoplasm when expressed in COS cells, whereas isoform 2 is enriched at the edges of the plasma membranes. When expressed in cultured hippocampal neurons, isoform 1 forms clusters mainly in the dendritic shafts, whereas isoform 2 is preferentially expressed in spines; MISCELLANEOUS: [Isoform 1]: Not palmitoylated; MISCELLANEOUS: [Isoform 2]: When Cys-3 is mutated to Ala-3, isoform 2 is not palmitoylated anymore.
Subcellular Localization:
[Isoform 2]: Postsynaptic cell membrane. Cell projection, dendritic spine. Note=Localized to the postsynaptic junction site of the parallel fiber-Purkinje cell synapse. Highly present in the dendritic spines; [Isoform 3]: Synapse. Cell projection, dendritic spine. Cell membrane; Lipid-anchor. Note=Localized at the dendritic spines, but also in dendritic shafts apart fron spines.
Domain:
PDZ 1 domain is responsible for cytoplasmic clustering of isoform 1.
Sequence:
MPATNQGWPEDFGFQLGGSGPCFVIEVAEGSSAHAGGLRPGDQILEVEGLAVGGLSRERIVRLARRCPRVPPSLGVLPGPEGGPTALTAAWLTRRFGRSLPLSRELLRLAGGPRPDAVHRERRRKAQEFSCQVDDILGDRLTAKEQVFTALKQFAAEQRVDELVWTLTLVLPSEAQGPVLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAAPRRPDEPPPRKATSLLGGRTGPGGPRRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPAENASLKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGPVPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQGRTFSQQLDHLLTPPERYGVCRALERFFQHRNIDTLIVDVYPVLDTPAKQVLWQFLYQLLTYEEQELCQEKIACFLGYTAMTEPESSLDLEPESTPEPTPEPQPRSSLRASSMCRRSLRSQGLETSLSCGPGDCPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKIGTMSKSRASPPVPSLVGTSGPRTLSGVSWPSDRLLPSPCYDPLCSGGLASPSSSESHPYASLDSSRAPSPQPGLGSIHADSPPSPDPIRPPSRRKLFAFSRPVRSRDTDRFLDALSEQLGPRLSIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASECVSSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDPKPSSRTSDGPRGPPQSLTKPLTQINHPVPPPPPPPLPPPVPCAPPMLSRGVGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPPKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLTPGELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTGDLADLHDTVSEIQVACQSMAPSSEDRFAVVMASFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFSEFMSKFERALSDLQAGDGPRSSGMVSPLAW
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Sequence:
MAAVQRLLRAAASSSSSSVAAGRRRMTTSLAPEQTPAAAPAFPFAGAERRRRPAHERNVQWVFLGCPGVGKGTYASRLSRLLGVPHIATGDLVRDELASTGPDAVQLKEIVNQGKLVSDEIIINLLSKRLKKGEEKGESGFILDGFPRTVNQAEILDGVTDIDMVVNLKLREDIIVQKCLGRRICSQCGKNFNLACIDVKAENGLPPIYMSPLLPPNNCMSKLLTRDDDTEEVVRNRLRIYNKMSQPVEDFYQKQGKVLEFDLPGGIPESWPKLLDVLNLEDQQEMKLAAA
The following text describes a protein:
Function:
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity).
Subcellular Localization:
Chromosome. Note=Accumulates at UV DNA damage sites.
Sequence:
MLKRRQPKYCSFMDSIDNSTTIIRKNLNRFIRELTDDGKLDFESIPYQNLQKEVANQDEEGCENVIEVLLDTTSRSGCPDRKLILQLFNSFFLQFPIFRENLLNDPSEFLELMFETNPIRNPLPGSKKHGNELKVEAITVIKSWEKEKCVKNDARMKCLVVTLKKTKFVDYENGAKKIEAERKRKKILEERKMKMIENSVNVYSSKYHEIKNDAETLSMELTTTMQMLVPSFTTADPEVPSTSTSTPSAISDSKSFEIFIPDLTPEISVSSENDAIVEAFLGAKLSLIHRVQTLRKLVKRLQLLKQPGEKLAQEIIDYRDGIKNLVLKADELRIINPRPPKNKRKKSDDDFIDVDISIDDILMVQYAEKLEVDVKSKDESEKITESPEKHKIEMKNEKPVKIKTVPFGLDLKYWGEERKDVEVPKNNADCHRFWRSADEGTVAGKAQQSIYTQRQYTFIGKAPDNRKVCLAKMKSGKLCPRKDYYTCPLHGKIVDRDDEGRPINEEDRLEENYRKEQNHLKEADKIRQMIEKEYESKTKRRKKHDVDTTASEDVRNRLQKKLLDPKTIQRVSADLDASRKNRLEKNFGQQFSHF
The following text describes a protein:
Function:
Required for melanocyte differentiation.
Sequence:
MFHAESLVSLNGTQLSFMGHDAKEIPHFLGDTYGQIARRLDLSFNQLRSLAGLKMFTELEELVVDNNLLGNDLQLPRLPNLHTLTLNKNQLTDIEALLEHLADVTPSLKYLSLLGNEACPNQLVSPDKDEDDYQRYRYFVLHKLPQLKFLDTRKVTKTELMEARARGAFMKVVKPKSEAVPNEAGSGSCSLPYTPLPRGSRDAKNHKGVFAKCRYIYYGKHSEGNRFIRNDQL
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MATRSEHLCNTMFVNGSDEELITILSIDGGGVRGIIPGTVLAFLESKLQELDPENKDVRIADYFDYIAGTSTGGLIAAMITAPNDQKRPLFAAKDINDFYHKNAAVIFPQKTEPDVGTLLGELVTTLKESNQIPNAAKDIAKFNLEESEQILQFVETYNGKSSGDKLMRSSFPDIIRSIWSLILTLWYPRYDGGHLRDIIQKLLKETMLSESLTNVIIPSFDIKLLQPTVFCTSKAKHEKSMDVQLSEVCLGSSAAPTYLPPRYFSTTTELKQVCHGTSIFDRHPPRTLKTSREYNLVDGGVAVNNPTFLAICEAMKEKKINARKLLVLSLGTGSSKGTNKLEVGSPDTAWGLVNWFFGPEQSRPLTDVLMAGSNEMVEIYTSSFFQFSGLEDNYIRIQVDNLTYAEASMDNSSKENLDNLEKIGKELVEANKEKLIKLAERLSAIRHASRSSLSG
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Sequence:
MDLSRLASVAGPSRAAPRAGLQIGAAGNGFRVCSLRHRGAGNGRLTSAAALLRGSSGLFYLAPARGGPPRLRARGRPRCQGSDSLAYVDGPLEAAKGSGEVYDDDATSSGPDDDDNDKGPADVDGLREMLQRCRNELEVARLNSTMFEEKAQRISESAIALKDRAEGAQRDVSAAVATVQEVIVKEADAKEAVQKATMALSMAEARLQLASEALDAKRGSVGPMEVSIEGVEEEALVSAQEEIKDCRAALLRCEEELERIQEQKMNLQKEVDRLTELAEKAQLDASKAEEDVTNIMVLAEQAVALEMKATQRVNDAEAVLLKAEKVISSVDTVVELTSLAEEQKSAEEDSVSEGYEYSSNGTDDVPVRDEVSSIERLMVGDLTVEGIEQLEPSREIYDEASSDKMSVEPQKEAEPDSDKLKQGKKQEMERKEFTKEPLSAQKSLKKRSSRFFPASFFSSKADGEFTPTSVFRGLMKSVQKQAPKLVVGILLLGAGAFFLNRAEKSQLFQQQEIATSIGKVTSTTKPIVREIRQIPQRVKKLIELLPHQEVNEEEASLFDILYLLLASVIFVPLFQKIPGGSPVLGYLAAGVLIGPYGLSIIRNVHGTKAIAEFGVVFLLFNIGLELSVERLSSMKKYVFGLGSAQVLATTAAVGVIAHRFAVLPGPAAIVVGSGLALSSTAVVLQVLQERGESTSRHGRATFSVLLFQDLAVVVLLILIPLISPNSSKGGVGFQAIAEAMGMAAVKAVAAITAIIAGGRLLLRPIYKQIAENQNAEIFSANTLLVIFGTSLLTARAGLSMALGAFLAGLLLAETEFSLQVESDIAPYRGLLLGLFFMTVGMSIDPKLLLSNFPMISMILGLLIIGKTLLVTFVGRVFGVSTIAAIRVGLLLAPGGEFAFVAFGEAVNQGLLSPQLSSLLFLVVGISMALTPWLAAGGQFLASKFEQHDVRSLLPVESETDDLHDHIIILGFGRVGQIVAQLLSERLIPFVALDVRSDRVAVGRALDLPVYFGDAGSREVLHKVGAERACAAAITLDTPGANYRAVWALNKYFPNVKTFVRAHDVDHGVNLEKAGATAVVPETLEPSLQLAAAVLAQAKLPMSEIQESINEFRNRHLSELTELCATSGNSLGYGFSRVMSKSKSISSDDESETVDGALAI
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions.
Subcellular Localization:
Nucleus.
Sequence:
MMPLSQTDFSPSQFTSSQNAAADSTTPSKMRGASSTMPLTVKQVVDAQQSGTGEKGAPFIVNGVEMANVPIILLFVLWSVDMQMFSALIHLPRFPFQIRLVGMVNAKVERTTDVTFTLDDGTGRLDFIRCTFSVGKSPCFCADVHWLSRNGMYIAVIGSLKGLQERKRATAFSIRPITDFNEVTLHFIQCVRMHIENTELKAGSPARINSSMGVSFSNGFSESSTPTSLKSSPAPVTSGSSDTDLHTQVLNFFNEPANLESEHGVHVDEVLKRFKLLPKKQITDAIDYNMDSGRLYSTIDEFHYKAT
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MLEAQVLHANLWKRLIECINGLVNEANFDCNPGGLSIQAMDTSHVALVHMLLRDDCFTKYQCERNSVLGLNLASLSKVLKIVEATDSLTLRHEDDSDVVTLTSENGERSRKCEYQLKLLEIETEAMGIPEMDYKSIVTLSSQEFAKIVRDMTVFGDTVNIEILKESVKFSSCGDVGEGYALLRASHAPTVDPRSKGESDVKTEDEEADACSVRTHSAKGKDGPLGIGVDVRTNEPITLSFALRFMNIFAKGATLSDRVSLKFAKESPCMVEYSIDQVGYLRYYLAPKVDDAE
The following text describes a protein:
Function:
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB.
Subcellular Localization:
Nucleus.
Sequence:
MSAALFSLDGPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAAAPAMYDDESAIDFSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRLLKREPDWGDGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREKSAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQLTRDLAGLRQFFKQLPSPPFLPAAGTADCR
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MPVSLSLLKHLQALHSTINVQLKADPETDEVLAQVTLLPEINISQEENDAEMEPPFPPLPEFRVHSFCKTLTTLDASLHGGFSVPMSFADQCLPQLVHVNLRGLRQPRRHLLTSGWKDFVNSKRLGAGDAFVFLGFAFVLNLMIMMRGENGELCVGVRRAMKPRSNVSASISIFGMYLSVLATTWEALARRTMFAISYKPSFSIYFFTICYCEFSGTIVGIEDADPIKWPGSKRRCLKVFRLCEMGWNLYHNSSGKVSPWKIELALTYTILSPLPMPWPEPNMVPLSPNSSVLTQEGILKSQVYHLGSLRVTIQPSQGSGFSRVSQCHEISTFGDNFAKMN
The following text describes a protein:
Function:
Putative taste receptor which may play a role in the perception of bitterness.
Miscellaneous:
MISCELLANEOUS: Several bitter taste receptors with distinct ligand specificities are expressed in a single taste receptor cell.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLNSAEGILLCVVTSEAVLGVLGDTYIALFNCMDYAKNKKLSKIGFILIGLAISRIGVVWIIILQGYIQVFFPHMLTSGNITEYITYIWVFLNHLSVWFVTNLNILYFLKIANFSNSVFLWLKRRVNAVFIFLSGCLLTSWLLCFPQMTKILQNSKMHQRNTSWVHQRKNYFLINQSVTNLGIFFFIIVSLITCFLLIVFLWRHVRQMHSDVSGFRDHSTKVHVKAMKFLISFMVFFILHFVGLSIEVLCFILPQNKLLFITGLTATCLYPCGHSIIVILGNKQLKQASLKALQQLKCCETKGNFRVK
The following text describes a protein:
Function:
Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Participates in ovule development.
Subcellular Localization:
Nucleus.
Sequence:
MAPDNDHFLDSPSPPLLEMRHHQSATENGGGCGEIVEVQGGHIVRSTGRKDRHSKVCTAKGPRDRRVRLSAPTAIQFYDVQDRLGFDRPSKAVDWLITKAKSAIDDLAQLPPWNPADTLRQHAAAAANAKPRKTKTLISPPPPQPEETEHHRIGEEEDNESSFLPASMDSDSIADTIKSFFPVASTQQSYHHQPPSRGNTQNQDLLRLSLQSFQNGPPFPNQTEPALFSGQSNNQLAFDSSTASWEQSHQSPEFGKIQRLVSWNNVGAAESAGSTGGFVFASPSSLHPVYSQSQLLSQRGPLQSINTPMIRAWFDPHHHHHHHQQSMTTDDLHHHHPYHIPPGIHQSAIPGIAFASSGEFSGFRIPARFQGEQEEHGGDNKPSSASSDSRH
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MTIVTGSGVYTDRYSSLYHKFCMLRLPALPQPSLRWTVLCAEWTLLAMITVLELLNNNSLAAVPMMAALLGFTGIFWALSFYFPLEAPAWKKKLYIAAELMLAFAAMWIGIGYDTLIYLILIKSCLFLGRGEVILTVVITAVFYLLTTWRQQFADDSETLNIGFDMLNASIYHLGISTFVILLGFVIVAERRSRARAEELAEELEGLAANLERARIARDIHDSLGHTLTALDVKLEVAQELYCRDPDRARQAVHTAKQLSGQCLQDVRLAVQAMRRPPLHLDAALEGLAEQVRQNRALAVEVHIDLPQLPLQTSHQLYCIVQEGLTNIQRHARAARVSLRACHTPQSVTLELWDDGQGFDPQATHGGFGLRGMHERMQVLGGSLAIASAPGRGTRIRLSVPR
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MDFHRLNTFGVFQRLWPHYGYERDFGELREREFPRMTGVTYLDHAAATLHPDSLLRGYFQDISSNVYGNPHSHSPSSRLTHDTVERVRYRILQHFNSSPDEYSVIFTSGCTAALKLVAEIFPWSPQTDQETGSVFSYLTDNHTSVVGMRGQTSALGVAALSVLPEEMENKEKEDCPEEDALCQTAHLFCYPAQSNFSGRKYPLSYVRGIQTRRLYPASHRRGRWFVLLDAASYVSCSPLDLRDCPADFIPISFYKMFGFPTGLGALLVRNSTAGSLRKTYFGGGTAAAYLTSEDYYVEAANISDRFEDGTISFLDIVALNHGFESLYRIAGNMHNIQLHTFGLARYTFILLSGLCHGNGRRAAQIYADGHFDSPATQGSILNFNLLDSNGRIIGYSQVDRMASLYNIHVRTGCFCNTGACQALIGITNQQMKRNLQAGHVCGDSIDLVDGQPTGSVRVSFGYMSTFEDCQKFLSFVAECFVEKPVTVDPDRLQGLLPVSAPSERSNGVSPIQAFQEESCEVVQREEPVERRDAYTLTNIYIYPVKSCGAYEVHNWPVGPLGLLYDRAWMVVNRNGVCLNQKREPRLCLISPRIHLPSNKLMLQASGMETISVPLEKDILLHTGSAVSQSKVCGDRVETVDCGAEAASWLSGFLGQPCRLIRQSPDFTREMKKRPCDGLVQNALMKGRFKVVLSDKVLFFCGWRRLRCISSDISFCASDSENRLTSSKLWDTDQPQLKAAPSPSLSLVNEAQYLMINLASVKLIQSLMSSRQGGGEDQELLVSQKVIRRFRANLVITGGEAFDEDNWSHLIIGSTRFVVAGQCGRCQMVGIDQDTGAKCKEPLVSLSALRGGKVTFGVYLTHETADGSAAGHALSVGSVIQPEPHGP