lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRSTTLLVLLFTLLAACLPLVYAAALPNPDEWTNTNYFKQIDLAGSTSYTLTTLNVKPKSSNSTAASGTSASTLPYHFLLSAHEAQHLSWSRLTVKPALDSELASTSELKGGARPVISLQRLGEVDGDAYKSVLFEAQIPTTVLGADGATLSLETALNHITLPLPSTVKQTDPQLFLWSGDAAVRSPYTTENARIKVKAASPNILSFTPSDATKSGSIVTYGPFENVAAFVANTATDQGTVHFQADTPRATIVSLDRTAEISHWGDALSITDRILLRNSGPTLKGHFSRIEHQMASFYKRGAGSALSSLSFTLPAGVKDAWFIDQIGNVSTSRFRASKPNAELVTLSTGVPTSQAVASKMSLLELQPRFPLLGGWNYTFSIGYTLALSTGWTKRIAGTHEYVTAVPLFTPLKDVAADCVSTTIVLPERSTRISIQLPFDMDTVDHSITKTYLDTIGRPALKVHKQNCSPHHAQLVYVKYTLSHTANMSKVAAVAAVTALLFLATAVLQRVQTNIG
The following text describes a protein:
Function:
Odorant receptor which plays a critical role in the anthropophilic host-seeking behavior; establishes the host preference to transmit malaria. May participate in the phenomenon of decreased host-seeking behavior in disease vector mosquitoes after blood feeding.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKLNKLNPRWDAYDRRDSFWLQLLCLKYLGLWPPEDTDQATRNRYIAYGWALRIMFLHLYALTQALYFKDVKDINDIANALFVLMTQVTLIYKLEKFNYNIARIQACLRKLNCTLYHPKQREEFSPVLQSMSGVFWLMIFLMFVAIFTIIMWVMSPAFDNERRLPVPAWFPVDYHHSDIVYGVLFLYQTIGIVMSATYNFSTDTMFSGLMLHINGQIVRLGSMVKKLGHDVPPERQLVATDAEWKEMRKRIDHHSKVYGTMYAKVTECVLFHKDILSFGDEVQDIFQGSIFAQVCASVIIICMTLLQATGDDVTMADLLGCGFYLLVMTSQVFIFCYVGNEISYTTDKFTEFVGFSNYFKFDKRTSQAMIFFLQMTLKDVHIKVGSVLKVTLNLHTFLQIMKLSYSYLAVLQSMESE
The following text describes a protein:
Function:
Plays a role in the sugar gustatory response.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFPLLTEDFYHPPNRPRFINGGGYFCRSIRPVLIVGQMFGLLPLDGVWCGRWWSIHWRLLSWRNLYALFVQLGALIMACFSFATFWYSGVEFAKIMSWWFFTLNLLISINFAVLARSWPQLMSRWVQLEQSLPDQPRLSAACRRNARQVGLVATVLLTSGLIEHVLSKPAGLHRAYRCPIPNLLEAHYKQAFPEMFSFVPYNPYIGFLAQTITSLLTVYWNYVDLFLISVSVGLRTNLAQVNDVIASSEKLYHRGIFWKDQCTHYRRVLGLIRHVNNHIGVFIVISYASNLFFICVQLVNVFQQNSSFIVTSYFWYSLFHLIGRIVAVSLYGSAIHDEYCRTRTLFYNLPDEYGYTDEVQRFHRQVEHDSVALNGYGFFYLTRKLILKASTVVTYELVLTQVNEAEAKNGDDNPCT
The following text describes a protein:
Function:
Catalyzes the proton-dependent transport of sialic acid.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIKQEFGLTLIQATSLISAAFISRWFGGLVLGAMGDRYGRKLAMITSIVLFSFGTLACGLAPGYTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASGFLISGFSIGAVLAAQAYSYVVLAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHLSYLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVVVFCAFLYSWPIQALLPTYLKMDLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKAYVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGIAGLLPKLLGGYFDTEQRAAGLGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVRPSGLRMVDAIDGKPFSGAITAQHARVVTQK
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MATPDAPITINTNLLKSFSSKSFHLRSPSLNSVRLRRVFDLFDTNHDCLISLDEITRALTLLGLDANSPDLNTIISSHIRPGNTGLTYEDFVSLHRSINDLIFSVEEEAGCKEEQDEADLKEAFKVFDENGDGFISATELQKVLGKLGFTEANEMGRVKLMISSVDLNHDGRVDFSEFKDMMRALQ
The following text describes a protein:
Function:
May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol.
Sequence:
MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQRELEDVLMDPPMEDQSSDRDHGDEVRTDGDGEEPVVLEASASSTINPVSVAGLQKPEMSLPVKPSQGDCGDLSPFTPVTDEDSVVFSKLTYLGCASVNAPRSEVEALRMMCILRSQCQISLDVTLSVPNVSEGTVRLLDPQTNTEIANYPIYKILFCVRGHDGTPECDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSAIATPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSRGKDVRSGDMHLLDLESMGKSSDGKSYVITGSWNQKSPHFQFVNEETPKDKVLFMTTAVDLVITEVQEPVRFILETKVRVCSPNERLFWPFSKRSSTENFFLKLKQIKQKDRKNNSDTLYEVVCLESESERERRKTTASPSLRLPQSGSQGSMIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILETWGELLSKWHLNLSVRPKTLSALVRSGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTTKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKAEIEKIRQKVDDCEHCREFFNKEGHVKVASSAKDGSDDDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTISSIKTVTGVQGKETC
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MMSEMRGTEPSEFRFESSTGEHHKTPSPSSSHGNETRMHMDYPEPPSPRDPKGINDHVKVTFDEIIAEPESAYSYDQVWDVSKRTYKGTKSWCYRILSFCCAVPLAFFWGLYFGCLACVQIWCVVPCVKGYVINLHCYGKIWALFLSTFVDPCFESIGRMFSGIKFTARKETIA
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MESRHRAAQRASPSAKLRHPSALARRSLRATEAALPAPGAGRGAEDNDGGRTAAIHAGRLAAAATAAVQRSAAAPGFVLGGAFGIFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGISYAKNFAIVGAMFSCTECVVESYRGKSDWRNSVISGCITGGAIGFRAGMKAGVIGCGGFAAFSAAIDYYLR
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Sequence:
MLSAYYNDPFLADFCLGNIPLRLASRQSSLAVLQAHECLRKLQIFFPRLWGQIITTTTQGDLDQETPLCAVENTGFFTDDVDFLVQSGQCDLGIHSAKDLPENPKATVVSITASIDPRDILVFHEKYLSIPLPRRLRIGSSSVRRKELLSLLYPSAIITDIRGTIQTRLKLLEEKNFDAIVMANAAVSRLGLRLPCTKILPPPYHPLQGRLAITASRHIRSWRGLFLTCGITEDVEIMCFS
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLIICFFVLQLLTWSRVLLAHESRNNCSRSIMSIGAVLDLSSQMGKHQKIAMQIALQEFNRLSCSKLDLKIENSHGNSAHAVASAMDLTQSKQVLAIIGTITHSEANLASEFDDTIKNIPILSLISPVARSEKSSPLLPYFIQEGYDINLHMQCIAAIVGEFRWRKVTVIYELDNWFSSDPGILLDLSYSLRLVGSEIDNHVALPSLSSLLDPKSTIENELNRLKNKSNRVFLIAHSSLELANILFEKAKQMSLVGKGSVWVIPDGVAGLLDSVNSSSILNMQGVIGFKTHFMETSKAFRRFKFKFRRRFVLEFPEEENINPSFFALQSYKATRAVAQAARESQGKLTLEQLFKSNISRNGKFWQSQTFNIINVIGKSYRELALWSPELGFSKNLITQQLTEMNTNSASSGILSTVYWPGGIQFVPKGWTHSTEQRKLQIGVPAKGAFTEFVNVTYDKNRNKTSITGFSIDVFKEAVHNLSYDLDFAFVPFNGSYDEMVEQVYNKTLDAAVGDTSIMAYRYHLVDFSQPYVDSGIDMVVTEQSAKSKETWIFLKAFTKGMWLMMAALHIFVGFVIWLIERQVNEELKGFGSMLWFLVTVIFYAHTGEPIRSPLARTVLAPWLFVILIATSTFTASLTSMMTVSQLEPSVLDIKSLLKRNSPVGCNGNSFIVKYLTEVQKFKPENIRRINSINDYPSAFQNKDIEAAFFIAPHAKVFMAKYSCRGFIKAGNTFRLGGLGFVFPKGSTLATDISEALLKVLESGEIEQLEKDMLTIEGNASCSPLESKAKDGSPTGFQPFLGLFCICSIVAVLALLYNMICLLMSNVLTFTSYIHLTLTQLRRIWRWTTRYFARSSSRFQSGSLRSVSTATVTRNAEETVINTQ
The following text describes a protein:
Function:
Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility.
Subcellular Localization:
Cytoplasm. Note=Detected in the intercellular bridges. Localization to intercellular bridges is identified in all stages of tubules but dynamically increases from stage I pachytene spermatocytes to stage XII secondary spermatocytes and disappears after the formation of step 1 round spermatids (stage I). In addition, it is localized in the cytoplasm in pachytene spermatocytes to secondary spermatocytes. The cytoplasmic signal increases dramatically in stages X-XII, decreases from step 1 to step 3 spermatids, and disappears in step 4 spermatids.
Sequence:
MQATAALETDSDKNYPKNGGHFQNDKLYNPKKENMFFSNGCNGVILAFPDGKEDSLATEERASDKENSIVDQRDLSELSFSENQDSNRGNIFSQSSEFEDSNDYAFLNETYSIHYSESKLKDENLLHLYSGLHPEVHKRVEMIFDTLDNNSIGLGRSAEASGADCGDVQKSDVDEDSQQEYHSAELECISAHLAKTVSRSSLDVSELKTSSYDFKCGGNFEDNHGKLESGPSPSLESLNGFAQECSLQVSTSQSSDMLQEYHEPKYEKCKEQEVDLTYHKAFDGILQRSSSPLNHQKVPETQVYTKEVKSQTTESKDFYGNRIFQNKALQRPENATMFPQDRALETHLKANDAHQPSGPCALDDSVISLCGSSQYKSLPEPGFFSPVIPRVAVTDYQAEVEGSCLHHVQGSATNKACSLMKEVCLTSVPDAAACIAAVQQTLHVSSRVNASSSIVSASSITETKMVRQSQAEEWQSDKRSVACNTAWSCGQQCRDAQRAAPGSDSGRPLSTGCLKPSGNSLNENSLELRKVFDTTDRQKHCNRAFQLCEEKAVPSRCCQKTTERAIKAEMHLLDVCYQMCHRHCHHIYKLVMESRAGLNRNLQTDSAKKELGAALLSVLEDLKLRYMNLKGKVHKGIPLEELPPLSVESKLLSAFSDFVSRLMKDEACSLSGANSELDNQSLPDVDVSPGLLKTLSQMSFIPDSSQPEQGKSPMSDVCKNGDTDIGFNCLKLNDKECKTVQEASEDWFDATERLIGADFSETQDSTAECEEWQPRNPLELKNSELHGKGQGFLIHVGGLCPSVSEADLRSHFQKYQVSEISIYDSTNYRYASLAFAKNSNAKMAVKEMNGVKINGKSVTVRLVKIPGEYTPPPLSTTGNSTSMNHLEKNTNKDATSASSICRLPRAKSRQLESEQDSEFPPLDQGVKKNCNQMKSGQLLPETPFQFIPPNTLNLRSFTKIMKRLAELHPDISRDHIIEALQEVRINHKGFLNGLSINTIVKMASSFLRNSALK
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Sequence:
MTVALAFESDDGSRAIEMQVQVQETDGVRTEDCDLNKFFDIARTVEQIRRGGYRKIALQFPDSLLPDASQVQQELKDGLSGQWERVFVLGDTSYGSCCVDEVAAQHLVADCIVHYGRTCLSATTKIPVIYAFGNATIDVDDCVQQLSEAVAGVDATKTVVLLYEPRYHHASGAVFAALEEKFSDRNMAFGTMKTFFDPTEEVKDVPCDEALSTSVLHIGGQEIVVNSGNAEITPETFALLYIGAESAHLTSILMRYSTVDCFSYNPEMMSTRKEGATVNRALMRRFYLVQQAKEAQIFGILMGTLGVNRYLDVVHGLQKLIKKSGRKSYLFVVGKVNVPKLANYAEIDAFVLVACQQNTLMDSKEFYKPIVTPYELQLALSPTEEWDGQYKTDFREVIPALEQTAQIVEQADGDDEDADKPFFSLVSGTYKTSSRTTASDREATTYALAASEEIDASTALQVKNERTELTAYHSEAADYLAAREYQGLDPRIGKTPAHPAVEGSTGIARGYTHETE
The following text describes a protein:
Function:
Carboxylic acid reductase that shows a broad range of substrate specificity towards aromatic acids, especially to phenyl carboxylic and phenyl acrylic acids, to convert them into their respective aldehydes. Also able to use aliphatic acids as substrates.
Domain:
The NRPS-like carboxylic acid reductase (CAR) has an unusual domain architecture (A-T-R), with the adenylation domain A activating and thioesterifying the carboxylic acid which is then channeled through the phosphopantetheine arm of the T domain, the thioester reductase domain R reducing the carboxylic acid to the corresponding aldehyde.
Sequence:
MSQQQNPPYGRRLILDIIKERALNEPNREWVSVPRSSDPKDGWKILTYLDAYNGINRVAHKLTQVCGAAAPGSFPTVAYIGPNDVRYLVFALGAVKAGYKALFISTRNSAEAQVNLFELTNCNVLVFDQSYKATVQPWLHEREMTAILALPADEWFPADQEDFPYNKTFEEAEWDPLMVLHTSGSTGFPKPIVARQGMLAVADQFHNLPPREDGKLMWIVEMSKRAKRLMHPMPLFHAAGMYISMLMIHYWDTPGALGIGERPLSSDLVLDYIEYADVEGMILPPAILEELSRDEKAIQSLQKLNFVSFGGGNLAPEAGDRLVENNVTLCNLISATEFTPFPFYWQYDQKLWRYFNFDTDLFGIDWRLHDGESTYEQVIVRKDKHPGLQGFFYTFPDSSEYSTKDLYKRHPTHEDFWIYQGRADNIIVFSNGEKLNPITIEETLQGHPKVMGAVVVGTNRFQPALIIEPVEHPETEEGRKALLDEIWPTVVRVNKETVAHGQIGRQYMALSTPGKPFLRAGKGTVLRPGTINMYKAEIDKIYEDAEKGVATDEVPKLDLSSSDALIVSIEKLFETSLNAPKLEADTDFFTAGVDSMQVITASRLIRAGLAAAGVNIEASALATRVIYGNPTPKRLADYLLSIVNKDSNQGTLDNEHHVMEALVEKYTRDLPTPKQNKPAPADEGQVVVITGTTGGIGSYLIDICSSSSRVSKIICLNRSEDGKARQTASSSGRGLSTDFSKCEFYHADMSRADLGLGPEVYSRLLSEVDRVIHNQWPVNFNIAVESFEPHIRGCRNLVDFSYKADKNVPIVFVSSIGTVDRWHDEDRIVPEASLDDLSLAAGGYGQSKLVSSLIFDKAAEVSGVPTEVVRVGQVAGPSSEKGYWNKQEWLPSIVASSAYLGVLPDSLGQMTTIDWTPIEAIAKLLLEVSGVIDNVPLDKINGYFHGVNPERTSWSALAPAVQEYYGDRIQKIVPLDEWLEALEKSQEKAEDVTRNPGIKLIDTYRTWSEGYKKGTKFVPLDMTRTKEYSKTMREMHAVTPELMKNWCRQWNF
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MSRRQTLANVSPSQLNAKLGGNNAAGPGRSAKDPPGALPAKGRKSMAVGMVADRPSAVGAGLDPRRSSAFGTKPSGPKQDPRPLSSKDYQASCIRAVITYLSTHNFPAAVAPKTLASPTGKDFATIVTFLFQQVDPTFRIQGKVEDEVPVFFKRLNYPFQISKSALFAVGSPHSWPAVLAALTWLVELLNYMEKADDNAGSAFERENKVEQEFLDYLSAGYGAFMSGNDDRCQQLDDELAAKFTAREGDLVARCEQLKRANAEVLAELERLRSLPDPVVVAQQQREEQLVDMQKFEQLIQNLQGLKQTLTRKLSEKKSDLQAKQDQIAGAVADVEQLRQRVASQTINKADLNRMIMERNKQNEMLNSEKEKCEQMECKVHEQEVQIVHRLTALESTVERYNKLAHRLKLIPATSKRADGTNYELRINRDSANQAEFSSLDLKGVVKPGLERLCEMYRTRASELSQDLISLREACVARAERNVEKKEENAALEGEIARLEAQLQAAKDAHEEKCRRLVAQADSIKAQVDEFRSAASNRTEHMEERLSRVQAAYEQTKRDSEAELSRLESDLKAAMQMLIAHKEAVGGAISRAAGAVRQVKAELAAGGAPRPVAVA
The following text describes a protein:
Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRKVPNIIITGVPGSGKSTLCEELKEIINKELLKRNDMEGFEMTHLNLSNIIKDERLYKEFDDELDASIYSEELLNEYLKKKYKLEKGGYIIDFHDINFVKDVDIIDKIFLLTIQTNFLYERLEKRNYTKEKIKNNIECEIFQVIKEDILDHFPNTNILQEIENNDLQQYDNNLSIIKNWVLSYI
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MGWRASTHSDKSTTTDLFEGPTPRHSLLSGRYKQSFAYLTLRTRMPGIMQQIIMRLLSDLPDLVNKYGEEVRKDVKQIVDAVERLKMELNRDRQFLLFHGAEPDKVEWNAFITEMPRPKKSFFRACWLHAECYLYRRIFSFFENSRHLQKYDCFDHLKKEDLMLSEMAMSALARATRGLAKSYDAFSKLLRINLWGNHFEMQIGAFRFTEEDSKDDINVLVKVADIDRILLVDDTTLIWNCLVLASKSSGNRIVDFICDNGGFEFFTDMLLLEYMVDNNLATQVRLHVKAIPWYISDVTRADIEWTLDFLTGHRDECLSALGKKWTHMMNTQKIVIAPTSYFWTGPQPYFVMVESDIELYRLLTTSKLAIFKGDLNYRKLLGDFIWDSTEEFITCLRGFRPTNICALRTVKCEVVCGLSEGLADSLLKNDHNWMISGNYGVIQYTDSLKCSCALPGVDSSEKNTRMPGMVVPPSERSTLTPNHP
The following text describes a protein:
Function:
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity).
Sequence:
MALLCYNRGCGQRFDPEANADDACTYHPGVPVFHDALKGWSCCKRRTTDFSDFLSIVGCTKGRHNSEKPPEPVKPEVKTTEKKELSELKPKFQEHIIQAPKPVEAIKRPSPDEPMTNLELKISASLKQALDKLKLSSGNEEDKKEEDSDEIKIGTSCKNGGCSKTYQGLQSLEEVCVYHSGVPIFHEGMKYWSCCRRKTSDFNTFLAQEGCTRGKHVWTKKDAGKKVVPCRHDWHQTGGEVTISVYAKNSLPELSQVEANSTLLNVHIVFEGEKEFHQNVKLWGVIDVKRSYVTMTATKIEITMRKAEPMQWASLELPTTKKQEKQKDIAD
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MKKETTFDAMKATVQRISFAFSCFSNIILILLICTNSPKKIGSYKYLMIYFCVFAIFFSVLDIVIQPYILSAGPGFIVITEIKDTFLGPFGETCFLSSICGCFGVILATIAIHFIYRYFALERKGKLKYFQGGYLVVWLFVPLFVGTVWTIVTVYFCAPNDITLEYSRTLMKDHYEIDLENVTYIGSIYFVKDANGKSVMNKFALLGMAILFSIMGVSLSILAYFATKCYTRIKKLIYEGESSYTRNLQKQLYKALVAQASIPMFFIFTPIGLYLTLPLVGIELEISGEIATFVYALYPALDPLPIIFIIHNYRDAVLEFLGCCNVNNRIGAEDEPTSVTRHVSNCS
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MALLRQAYSALFRRTSTFALTVVLGAVLFERAFDQGADAIFEHLNEGKLWKHIKHKYEASEE
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKEIKVIIAGPRGRMGHEAVLLMERTEHFNLVAAVDYKHGGEKISDLPGMPALHAPIYADLHTCLDEVEADVLLDLTTPEVGKQHVTLAVERGLRSVIGTTGFTEEELTRLTENAKEKAVGTIIAPNFAIGAVLMMKFSQMAAKYFQDVEVIELHHDQKLDAPSGTAVKTVELIRQNRESKQQGHPNEVEQLAGARGANVDGIHIHSVRLPGLIAHQEVMFGGDGQMLTVRHDSFNRASFMSGVKLSIETVMNLDHLVYGLENIID
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MMKVASLFKFWLMIGFAAGSPLTKVGAPSTHFDYTNPQKWEEHESNCAGQHQSPININTDEVIVTNYPKFIFQNYDLVFPESLENNGHTVELKIDNEDDEDDLPSISGGGLDDRYNFAQLHFHWDEGLLGSEHTINRQKYSAELHVVHYNTKYGSFDNAVPHADGLAVLGILIDLQARDNIAFRHLEQFDKIIDPSRTISDRLQFSVPLVDLLPDSTESFFRYNGSLTTPGCNEDVIWTVFETPIAISVRQLAKFRLLNDENGMPLRKNVRPTQMLHDRVVTYRPDPNPIQSLFSFPSNLPNLFKPFSNEFQQSNF
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Sequence:
MDVRFISLTKPEIVIDGEPLSPEGLIAYCARVSSPNQENPNYTKLLQFCIREGHWSIFEMVDMTLEITTTRAIAPQILRHRSFSFQEFSLRYSCATEYECYEARRQDVKNRQNSLDDFDESTKKWFNQAQAAVWEKSHQLYEEALAKGIAKECARSILPLNTVTRLYMKGSVRSWIHYFSVRCDQATQKEHREIALAARKIFMKHFPTVAAALEW
The following text describes a protein:
Function:
Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair. In physiological conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex. Acts as a negative regulator of nutrient stress-induced autophagy by inhibiting JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (By similarity). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin. To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (By similarity). Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability. Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis. Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53. In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2. Upon heat-shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival. Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis. Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasmic vesicle. Mitochondrion matrix. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. Nuclear localization may be necessary for DNA damage-dependent stabilization of the protein.
Domain:
The tetratricopep-repeat (TPR) motifs may function as protein interaction domains.
Sequence:
MMADEEEEAKQVLQKLQELVDQLYCFRDSYFETHSVEDAGQKQQDVQEEMEKTLRQMEEVLGSVQVEAQALMLKGKALNVTPDYSPEAEVLLSKAVKLEPELVEAWNQLGEVYWKKGDVAAAHTCFSGALTHCKNKVSLQNLSMVLRQLQTDSGDEHSRHVMDSVRQAKLAVQMDVLDGRSWYILGNAYLSLYFNTGQNPKISQQALSAYAQAEKVDRKASSNPDLHLNRATLHKYEESYGEALEGFSQAATLDPAWPEPQQREQQLLEFLSRLTNLLASKGKTKPKKLQSMLGNLRPAHLGPCGDGRYQSATGQKVTLQLKPLSTLQPGVNSGTVVLGKVVFSLTTEEKVPFTFGLVDSDGPCYAVMVYNVVQSWGVLIGDSVAIPEPNLRHHQIQHKGKDYSFSSVRVETPLLLVVNGKPQNSSSQASATVASRPQCE
The following text describes a protein:
Function:
Involved in mRNA splicing. Required for snRNA accumulation and manufacture of snRNPs.
Miscellaneous:
MISCELLANEOUS: Present with 1870 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKRGESQAPDAIFGQSRAFALSDSSVNPDVIEYLKSVRQEALRTNAISIKNHMNLQKRTRHKSSMYDDEDEGALKRHAISPSLIRLQRNVEIWVRWFNSVKATVLTNAYEFTGYEDETLDLLLLFLKNYLEDMPSKCTTVEKIISVLNQHSFPEKAEEKEENLQIDEEWAKNILVRLEKTKIDSVEDVKKVITEGDKHELVGYNQWFQYLINNEPQHTTFHEKITSKQLWVLIKYMSNTWIKEIHKKGRHYRRLQDWLFYILVHTPERVTAEYTSILRDLGKKCLELIQKKPVEAHENKITLPKEMAELNVEIPAAVENMTITELTVSVIAVNYGQKDLIE
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVTGRGPCGTCAPALRSTSKDTILTHSDQPRPLQSRANGPLTGKVRVPGDKSISHRALILGALAVGETRISGLLEGEDVLNTAKSMQALGASVERTGDFAWKVQGVGVAGFAQPKAALDFGNSGTGCRLVMGAVAGCPISAVFDGDASLRSRPMRRILDPLEKMGARVVSGGEGGRLPLTLQGARDPLPITYKTPVASAQIKSAVLLAGLAAPGTTTVIESEASRDHTELMLKHFGADITSTKEGQHGRRITLVGQPELHGANVVVPADPSSAAFPVVAALIAEGSDVVLSDVMTNPLRTGLFTTLREMGASIEESEVRGDAGEPMAQLRVRASKLRGVEVPPERAPSMIDEYLVLAVAASFAEGTTIMRGLQELRVKESDRLEATAEMLRVNGVKVEVSGDDLVVQGRGHVPGGGTVATHMDHRIAMSALVMGCASDQPVTVDDTAFIATSFPDFIPMMRSLGAEFS
The following text describes a protein:
Function:
Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.
Subcellular Localization:
Nucleus.
Sequence:
MEQAQCGSRDRSGSGRPHLAPGLAAAAPAPLSPAMPVPPGLPVPPTFLRPPSLFLRAAAAAASGNGGCPPAPGLERGVGAVGCGYPRTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQVALRRQQAQEESEARGLQRLLYPGPSGTGARTAGGGGRTENPQGARGPPAVTAMGLGALRQASGLATPAFEVFQPDYTEEKQEQKESKCDSCQSGQEEPVSRSHRLTLGSSPKSNGVIGKQNVKSAIPGNSSKDDNIQSPHRGEQSGGEESPGSLSSSDLESGNESEWAKDFTATRAWLPTVSSRPRDPLDILTKIFPSYRRSRLEVILQFCKGDVVQAIEQVLNGKEHKADTRDLASSGELENTAFQKASSFNLAGIGFGTLGNKSAFSPLQTTSTSFGGDSSLYSLNPRLGISPLRLAYSSPGRGLPGFMSPYLTPGLVPALPFRPALDYAFSGMLRESSYLPSKDSVTGGRLYSRLNHDNL