lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells. Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3.
Subcellular Localization:
Secreted.
Sequence:
MHLRLISWFFIMLNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVNIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIMQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKGLESSKETPEQRENKQQQKKRKVQDKQQKSVSVSTVH
The following text describes a protein:
Function:
Probable serine protease inhibitor.
Sequence:
MGSDGLTAFALRLAKKLGEGDNTRGSNIAFSPLSLYTTLGLVAAGACGRTLDELLALLGAASADELAGFVHGLPSDPSGSGGPVITYTYGVFHQEHMELTPDFLHTATESYKAEIRAVDFAEDEVREETRKEINQWAAAETNNLIWEFLPEGSLTDHSRFVLTNAIYFKGAWETRFPENLTEDHEFHRLDGADPVDVPFMTLPGTCELFVSYNEGFKVLKLPYKAGDDAMSRYSMCVFLPDEDDGLHAMVSTLADMGGSLLDHVPKLRSRVRELMLPKFKLSFFCRLAQVLRGLGLREAFTEEAADLSGIMDKSVCDVRLDEVFHKAVVEVNEEGTVAAACAAVIGRKKKCAMRLEFIADHPFAFYIVEEVSGAVVFAGHVLDPSSSP
The following text describes a protein:
Function:
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFLPTMSGESMNFSDVFDSSEDYFASVNTSYYTVDSEMLLCTLHEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNAMCKLMKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRYRTLLRSKVICLIVWGVSVVISSSTFIFNQKYNIQGSDVCEPKYQTVSEPIKWKLLMLGLELLFGFFIPLMFMIFCYMFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGNMNRSCHSEKLLGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKIMKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM
The following text describes a protein:
Function:
Probable transcription activator linked to cell cycle that induces transcription activation of genes in the environmental stress response and metabolism control pathways, like the closely related YAP5.
Miscellaneous:
MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities; MISCELLANEOUS: Present with 1700 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MRQRRSVVAVSVKPKGFKLGHKQGSMSTTSPPPSSPDGNVSTSGPSAIKLSKNWELPQRLKPGRKPKSKRGDASANNDGSSKIKKVQTSNQKDQMTTKDHENEGAKGHEGKSDDEGNGSGDENGVDSVEKRRRQNRDAQRAYRERRTTRIQVLEEKVEMLHNLVDDWQRKYKLLESEFSDTKENLQKSIALNNELQKALPLIVNTPFQQQPENPPDNPISILEMVENFKPIGAVSLKKGKLKAHC
The following text describes a protein:
Function:
Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. Also acts as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus. Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity. In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites.
Domain:
The PIP-box mediates the interaction with PCNA.
Sequence:
MSCKKQRSRKHSVNEKCNMKIEHYFSPVSKEQQNNCSTSLMRMESRGDPRATTNTQAQRFHSPKKNPEDQTMPQNRTIYVTLKVNHRRNQDMKLKLTHSENSSLYMALNTLQAVRKEIETHQGQEMLVRGTEGIKEYINLGMPLSCFPEGGQVVITFSQSKSKQKEDNHIFGRQDKASTECVKFYIHAIGIGKCKRRIVKCGKLHKKGRKLCVYAFKGETIKDALCKDGRFLSFLENDDWKLIENNDTILESTQPVDELEGRYFQVEVEKRMVPSAAASQNPESEKRNTCVLREQIVAQYPSLKRESEKIIENFKKKMKVKNGETLFELHRTTFGKVTKNSSSIKVVKLLVRLSDSVGYLFWDSATTGYATCFVFKGLFILTCRHVIDSIVGDGIEPSKWATIIGQCVRVTFGYEELKDKETNYFFVEPWFEIHNEELDYAVLKLKENGQQVPMELYNGITPVPLSGLIHIIGHPYGEKKQIDACAVIPQGQRAKKCQERVQSKKAESPEYVHMYTQRSFQKIVHNPDVITYDTEFFFGASGSPVFDSKGSLVAMHAAGFAYTYQNETRSIIEFGSTMESILLDIKQRHKPWYEEVFVNQQDVEMMSDEDL
The following text describes a protein:
Function:
Catalyzes the degradation of L-methionine to alpha-ketobutyrate, methanethiol and ammonia. Exhibits a high activity toward L-methionine, L-ethionine, L-homocysteine and seleno-L-methionine, but not L-cysteine. Involved in an alternative cysteine biosynthesis pathway to the reverse trans-sulfuration pathway (methionine->homocysteine->cystathionine->cysteine) in which methanethiol is an intermediate. Also mediates an alternative isoleucine biosynthesis pathway in which 2-ketobutyrate is an intermediate.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHFLETQEPLVFSGKKRNDRDDEDGDALVAKKSALAVCDADPAAAIANIRHEFGEHGGVNMSIEASATFTVMEPDTMRRMFTGELGPDNDFYVYSRHFNPTVLNLSRQMAALEGTQAAYCTSSGMSAISSVMLQLCSSGGHVVAASTLYGGTHALLSHFLPRTCNITTSFVDITDHGAVANAIVEGRTQVLYFESVANPTLTVADIPELSRMAHEKGVTVVVDNTFAPMVLSPAKLGADVVVHSISKFISGGADIIAGAVCGSENLVKEMMDLRGGSLMLLGPTMNAKVAFELSERIPHLGLRMREHSHRAQVYAERMRDLGMKVIYPGLETHPQHKLFKGMVNRDYGYGGLLSIDMETEEKANKLMAYLQNATQFGFMAVSLGYYETLMSCSGSSTSSELDPSQKEAAGISPGLVRMSVGYVGTLEQKWTQFEKAFLRM
The following text describes a protein:
Function:
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
Sequence:
MDNAVDRHVFYISDGTAITAEVLGHAVMSQFPVTISSITLPFVENESRARAVKDQIDAIYHQTGVRPLVFYSIVLPEIRAIILQSEGFCQDIVQALVAPLQQEMKLDPTPIAHRTHGLNPNNLNKYDARIAAIDYTLAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLVLPASLKPLQHKLFGLTIDPERLAAIREERRENSRYASLRQCRMEVAEVEALYRKNQIPWINSTNYSVEEIATKILDIMGLSRRMY
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MATNSSTIEVRKPRDMLKTYYGLSTADSSAVNNLSQQSKRSSAADGNVGSPCDINGSNFDPEMYLDKLLKEKTLTELVDKEHEMVRMIRTLDSDMQTLVYENYNKFISATDTIRKLLLLKKMKSDFKKMEDEMDNLCSAKQLTECVDLLLQLNEPADMLCDEFLTQAREKIEADLSSLELQLQLCSNDFQSLAKTATTTSPSVTTTKFPTTATEATTAAAAAKSKNKHSFDVGDGKMSENVLHERGDALDGNAYNVMDILEFVDKGCNGFLSNICLVVASYNDMFLARQQEDMQLDAIALKKLIDFVNELMARYFYYVKMRVQLEKATGNNMILVRSLDRFHRRLQAMNKLLPDSDFSSHNKGGPGAGMSFGEMVKKLHSSLIEQVKSVLNNLQAFIHPDITFAMKQHFRTNFCLVEVRENFVVAFIRHIIQTTSSIRQTNLTLVNEQFQSDHHYHFHHQQQHNSFQQQQQHSFQTPPSSSLPPTSSSMTSSSTLCSEARSAAQQILNHYVKVQGTRSERLSDSTARRSAASRLMGGGKAQWNYAPSTNMDSSLMSNIQKLFYEKIEVFTPVQFNRVSIMTGLIKICLKTLLECVRLKTFGRYGLQQMQVDCYYLQLYLWRYVQDENMVHILLDEVVSSTIHRCLDPVPMEASVVDVICDKN
The following text describes a protein:
Function:
Involved in retrograde transport from early and late endosomes to late Golgi. Links the Golgi-associated retrograde protein (GARP) complex to the t-SNARE TLG1, leading to the fusion between the endosomal vesicles with the late Golgi. May also be indirectly involved in apical bud growth.
Miscellaneous:
MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Sequence:
MAEQISHKKSLRVSSLNKDRRLLLREFYNLENEPNKGRQEARIGEKASEAHSGEEQVTDVNIDTEANTEKPVKDDELSATEEDLKEGSEDAEEEIKNLPFKRLVQIHNKLLGKETETNNSIKNTIYENYYDLIKVNDLLKEITNANEDQINKLKQTVESLIKEL
The following text describes a protein:
Function:
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MEQLKEGNSYFVDEQYDEALKCYDKACLELSNNAEAFFKRSQCHSKLSNLKEALSDINTSIKLDSNNSKYYLKKGQLCFELEEFDTALKTFEKGQSIDSENSSFKTWIRKSKAEIQSNPTTTTTTTPTPTPTPTPAPQPVTTTTNPTPIPTTSNTTTTTNNNNNNNNNNNNNNNNNNTTTDSTTTKLPIPSSGNKVRHEWYQTETHVVLTIFAKFVTASNSKINLTSKSVNISFPLANGSEFLFEMDLFDPIVDKDSTIHYYSTKVEIKMKKSRAIKWDTLEFTDKSGPVGLMDQISSSPAVPSPYASKKDWDKLPNEPEEKLEGDQALNKIFRDIFSKGSEDQQRAMMKSFTESGGTVLSTNWDEVGSKKVVGEPPKGLEFKQYEK
The following text describes a protein:
Function:
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MKMIHQLSVRRGITPFLSTPTTLLRTGCQSTANIARHRLYASHPVINGHQNGQKSSETWMFFSGIYPISLGRFDFRPRLIGPNLKDLESRLRALMDRSEYPSLEIDQVEPRIKEGGAFVRFASVAPIEPGLLRAHLLAKIDDLNLKPFWLFNSRPDVHLVQGKPWLEDMNMCPNRKVMVEFEGPVLAQEELWTLFRPFGRVKEIHMPTPKDPIQIAHVTLDGIRPAAIARSCLHGLTYRTGPSGSFTRIRILYSPRIHAKTARDWLGSHPKIVLPILALLLGGISYTFFEPIRQFFIKSHIAGTFDLQQNAVFSWLQKETVGRLGFGRDLTGGTDLAGSAVEKERGDAVRELNTWLSGTPGTFFVVLGPKGSGKSQVVQSVLNERGNSLVIDCASLIQDATNDDVVIANLAKSLGYFPQFSFFASVNNAIDMAAAGLVGQKVGFSSSPEDQMHQILDTAEKALRDLAKDAFINRQHHFVNQNHQAGNAQSEKESIARLFQQVIESIPLSGRYLTDKTSDAPVVVLKDFSINASAKHQVLWDCLASWACRLTESGTAHVIFTSENSGALKPLTQAFSTRPVKSIVLTDASTDSALQYVSKRLSTDPNRKSTVLAKDSALIQIVGGRLTDLDLLVQKIESGLDVERAIEEIVRQSMEEIKRKCFVHGDHDQSKLLPWANHQVWDLIKRLSSHDEVPLYPILSETFDDDLSVLSALESTDLITLSTHENGETMIRVGKPVYRTAIERLLSQKHFAATHDLNWAKRRMKRAEESIESKLHELIELGKLFPTIYTVGSDRQSWLFGSTLPTQIRWKVKRILHDLDRLEQIVDSAESDLKRAKTTLYSSPPSVVSKKK
The following text describes a protein:
Function:
Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.
Subcellular Localization:
Nucleus.
Sequence:
MSESSPKDTLSALNESLDALEAALAPLEAKPWSQTVEKLSPLERTKMDVLGAYLINDLVWVYLKTKGIDPTKHDVTAELERIKTYYSKVSSAEGHEEIRPKVDAAAAHRFVSSSIPRTQHLPPTTSAELAANQRALRVAEEEEEESIRRLGKPSRFRHIQERGQLKLIPGQEVETIGDEDVMIGGEDGQREAENFLREFANEIEGR
The following text describes a protein:
Function:
Glycoside hydrolase releasing xylosyl residues from xyloglucan oligosaccharides at the non-reducing end. Has alpha-xylosidase activity against xylan oligosaccharides. Also has alpha-glucosidase activity against p-nitrophenyl-alpha-D-glucopyranoside. No activity against p-nitrophenyl-D-xyloside.
Subcellular Localization:
Secreted, cell wall. Secreted, extracellular space, apoplast.
Sequence:
MASSSSSLAFSLSLLLALILCFSPTQSYKTIGKGYRLVSIEESPDGGFIGYLQVKQKNKIYGSDITTLRLFVKHETDSRLRVHITDAKQQRWEVPYNLLPREQPPQVGKVIGKSRKSPITVQEISGSELIFSYTTDPFTFAVKRRSNHETLFNTTSSLVFKDQYLEISTSLPKEASLYGLGENSQANGIKLVPNEPYTLYTEDVSAINLNTDLYGSHPMYMDLRNVGGKAYAHAVLLLNSNGMDVFYRGDSLTYKVIGGVFDFYFIAGPSPLNVVDQYTQLIGRPAPMPYWSLGFHQCRWGYHNLSVVEDVVDNYKKAKIPLDVIWNDDDHMDGHKDFTLNPVAYPRAKLLAFLDKIHKIGMKYIVINDPGIGVNASYGTFQRAMAADVFIKYEGKPFLAQVWPGPVYFPDFLNPKTVSWWGDEIKRFHDLVPIDGLWIDMNEVSNFCSGLCTIPEGKQCPSGEGPGWVCCLDCKNITKTRWDDPPYKINATGVVAPVGFKTIATSATHYNGVREYDAHSIYGFSETIATHKGLLNVQGKRPFILSRSTFVGSGQYAAHWTGDNQGTWQSLQVSISTMLNFGIFGVPMVGSDICGFYPQPTEELCNRWIEVGAFYPFSRDHANYYSPRQELYQWDTVADSARNALGMRYKILPFLYTLNYEAHMTGAPIARPLFFSFPEYTECYGNSRQFLLGSSFMISPVLEQGKTEVEALFPPGSWYHMFDMTQAVVSKNGKRVTLPAPLNFVNVHLYQNTILPTQQGGLISKDARTTPFSLVIAFPAGASEGYATGKLYLDEDELPEMKLGNGQSTYVDFYASVGNGTMKMWSQVKEGKFALSKGWVIEKVSVLGLRGAGQVSEIQINGSPMTKKIEVSSKEHTYVIGLEDEEENKSVMVEVRGLEMLVGKDFNMSWKMGIN
The following text describes a protein:
Function:
ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment. Induces apoptosis in various cells (By similarity).
Miscellaneous:
MISCELLANEOUS: Whether ABCG4 is an LXR target gene, is still under debate. Studies performed in monocytes, and in one astrocyte cell line indicated that ABCG4 expression could be up-regulated by oxysterols and other LXR ligands (By similarity). However, subsequent observations in a number of different cell types (primary mouse cells, oligodendrocytes and neuron-like cell lines) have not confirmed this observation (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Sequence:
MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCTMAEKKSSPGKNELPAHCPTCPPELDPIESHTFATSTLTQFCILFRRTFLSILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYTLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALAIATALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLDEQCPFRDPQIILRELDVEEAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTLIHFSFCSAFILGLTGLALNRSPILSILLCLEGMLLMSMDGIVLTPLHLTIYLSSMMLYIMLPFAAPEAATGLSLNSDHYTTHGTDKLFSLNLLEC
The following text describes a protein:
Function:
Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity. When bound to chromatin, the brc-1-brd-1 heterodimer within the CeBCD complex is inactive during normal conditions, but in response to DNA damage, the brc-1-brd-1 heterodimer associates with other proteins such as the recombinase rad-51 or the E2-ubiquitin-conjugating enzyme let-70, which activate the CeBCD complex as an E3-ubiquitin ligase. Moreover, association between the brc-1-brd-1 heterodimer and rad-51 and let-70, probably requires DNA checkpoint proteins such as atl-1 and mre-11 in order to induce ubiquitination at DNA damage sites. To this end, the brc-1-brd-1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by ionizing radiation for example. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand break repair to ensure sister chromatid recombination and aid chromosome stability.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Note=Co-localizes with brc-1 in germline nuclei at meiotic prophase I. At the transition between mid- and late- pachytene, localization together with brc-1 is less diffuse and becomes a linear pattern along the chromosomes. In late pachytene nuclei, co-localizes with brc-1 at crossover sites and the short arm of homologous chromosomes.
Sequence:
MFENTKKALETFRTAIECVKCKKPRGDLQYLGSSCKHAYCWECIATFQQKPSGKRSSVARHMCPSCAFPLDTSKITEAHMLKTCFDTLSELNDLLQKVGTTSLTQAEFACTQNIFNKEKTPADAVEKFLETQAHMPDEMGQLGEEDDDLMCKDENRENSNSPELDIFHDYSKEASPTRNSTKRPSTVSVHERKPKRSSILKTSVKNEPAAPVVDLFASQVPQRTHQNDLLTPFIERRSTAPAATGVATYAQAFGSSSNPVKAEIIEEDIFSKAIPLTKRQASMSASAKKQPKLEPEEPEEVPSTSRSRKNSIKSDKIERRSQSPMSFGEKSMSVKSEQRRSSYGTRRGEAVLVNSIRNNRIPQLRSAVEAGTCVNEKEDGKTPLYVAVENSSLEAVKILVEAGAVINASCGSTLETTLHEAVRRQNTQIVEYLLSKGASIKIRNIAGKTVEEMAKSDPKIRKIIEKFKTEQRVLQPVVAPPKSRLHFVQLIDEKMLTESEKRKLPGKINIVPADMDSPTHVVVTVDLKTRVLNINKEHIGEILKAIIKSGMIVSRDWLRACIIDPSKVDDDRSYMVQKVRWMEGEVFENTIEQWKKTITKMQPKLFAGCKFFIPKPKYNFLDRPALFEIIRSAGGQAAAREPIIDEKDPPPYHNANLKPNFVLYSLTHDIGDKFRDCTKYNLVSEQWLIEAILGCSITTPPH
The following text describes a protein:
Function:
Catalyzes the stereoinversion of LL-2,6-diaminopimelate (L,L-DAP) to meso-diaminopimelate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MIFAKGHGTQNDFVLLPDVDAELVLTAARVAALCDRRKGLGADGVLRVTTAGAAQAVGVLDSLPEGVRVTDWYMDYRNADGSAAQMCGNGVRVFAHYLRASGLEVRDEFVVGSLAGPRPVTCHHVEAAYADVSVDMGKANRLGAGEAVVGGRRFHGLAVDVGNPHLACVDSQLTVDGLAALDVGAPVSFDGAQFPDGVNVEVLTAPVDGAVWMRVHERGVGETRSCGTGTVAAAVAALAAVGSPTGTLTVHVPGGEVVVTVTDATSFLRGPSVLVARGDLADDWWNAMG
The following text describes a protein:
Function:
CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. Counteracts the activity of PA phosphatase ned1. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in pre-tRNA splicing.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MSTKLTWSQWSKKHEIPRKALHTSIGFFALLLQGCGYHAAQIIPVIEIGFIPAFTGDVIRFNWPAFSRLYNRVIGPLMRESEKNAWNGVIFYMIGVWIVLKVFPEEIAVMSVLLLSWCDTTASTVGRKWGKYTPKIAKNKSLAGSLGAFVCGVFCCYVYWGLFRTGPDSLAAQSRIPFPWLCLINGFIGAFAEAMDVWGLDDNLVIPVVSACLLYLIM
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MNRNRKSVSKTPVQKTNLFHFFQRTPSSAVHNQVSSTPLADASVSTPSSSSLNASTPFITRGRPPTECPACNKIVPFYKLNHHLDNDCVPNSPISSSPRTTRLIDLTVPEIVLNSPPSTTAKEEVITELKTPSSNFILNTTSTPSKEEKPNSSSSTIVFHTPPPTPNIQKERRKFNSSSKKNFARRREIARQFTDRQVETDYKKHSENKLDKHEDWSSVKKKLFTEESKPKFEGLPYYLETFLFLLKSTFDEPLNQHLFNEEDKDTYKNFKSLSLEAQKLYARLFSRKFQWRRKEKIDYKDIASDLGPALKELCSSSLLHGIDQLEDLPTLLKLLTQLELKQLFKDAKIPFNGKGNATEALLKHCRSQPCLSGSSLSMKDRMIAKIKGHYLKECYKLHEEARRTFLRLILLSTLHQRQEEEEEKGQQQQNFKMLQVKIGDKCFPSYRINRQRAIFKHRDHFLKYGEASLLELQVRESYDNKQWGTLVEMTDPIQQAFVEYSKEYGNDDLDLPIFLRRYTAGSVYVYTFNKRIEALQCLKKYKEAVDLIRMLINQDVYLLSHRGHWYERLALNLEQHLKEPYEAFETIKNALDDSWVSPAHRFALSQRATRLCQSPRWKQKLEPLLSGLTLLIPAEPRCVTITGRSLPRDLPGHKSMFIRGDSEINTDAGDVTLCSVEELVLQHYMENGYTHGLHGEGSTLWTVIGLLFWDIIYQSEIADVFISLFQAMPLDFDTLDFYQSRKEIIEKRLECIRNWSSSEIVEEIAKVWEQNHGQSSLVSWDRFRDLESIGGLVQCIPPPVLAAISQRLLQNYRHYRSGFPDLTIWNPQQKKWRIIEVKGPNDRLSTKQTLWLDFLVSLGVEAEVCHVEAVGAKRMGATPQVAVKSKSPRTVDDEEDRENDKVVRKSRRLTAKKDSASK
The following text describes a protein:
Function:
Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MISYGQLSRRFPLNRLRSSGLSTGFRRFPSVILSNHSSQFKYPPFSSHPHHLKSTPTSDQDPTRSTSKIQPPNPGGIQQHDHQSLIASYLPSIRSLASKLPSNLRHPPTASDLLPLTKSTLDRLHIRLKWLTIRSFHPYRTDDYSAFASLFVLINIILAAIGTTTFLGIFLFLFNKAGMEDLVARWLSNRLSNASGVEISFDSALVPRWTDGMIRFENVRVSRGGHSLGPDAARLMSLVLDSNIPNPTPRRTLDLSPLHPDQHPTASEQESHFPEFTTPSEPDPALANCTHFHLTIASIDVTLSLGRWLDGKGLLRQAEVRGVRGVIDRSHLPAWSGESATPIDRREFRKVATAGDFHLEQVMIEDLLVTIFQPSNFRPYTFSIFNATFHKLRKQWLFLDLLSAEQMTGQVDNCLFSLHKPQSITQSNAKAGLYDQTLSSRQLENGRESYKRYKTRLSRFRIDGVPIDHLQGNSTGPGSDGPLSWINSGRVDVIADIRLPLEIDELDLRTVVREIVDNFEKELEIHQRTGDENDDAAHHPSSKRNGLISERRNLIKPHLKSPNVEESLKVDLASHHENDELLLERNDQETEEQVAIELDLRFKDLKASVPIFSSSLSYVNNALVRPIVAFINANRTLIPIKCQVKLDLEEFNGSWTTYDIGLIEIISEQVYEALAYHVGSDKVAQSNRLHKVGRWGIQMTANAILNALKQHWDAAH
The following text describes a protein:
Function:
E3 ubiquitin ligase.
Subcellular Localization:
Cytoplasm.
Sequence:
MGALTSRQQAAVDEVDIPCGSVYRYPPKSGSYFASHFIMGGERFDATHPEGYLFGENSDLNFLGNRPVAFPYAAPPPQEPVKTLRSLINVRKDTLRLVRCPEEAKTPGEEANKAKVQYNVEFTFDTDARVAITIYYQATEEFQNGIASYVPKDNSLQSETVHYKRGVCQQFELPSHTVDPSQWAEEELGFDLDREVFPLVVHAVVDEGEGTHTDGTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKNLGPLSPTGFNPIISAQTSDSEEHSSSEHIPAGYEVVSLLEALNGPLTPAPAPAPLPSLTDGHLAGMLPSYGSDGHLPPARTLSPLDRLPDCGGPGLKLKKSLSKSTSQNSSVLHEEENEQSCSESESCLSQRRSPRQPGERGVTPDSENLTLSSSGAIDPSSCTGTPLSSTISSPEGNPVSSSLGQSVMSMASSQSQHSQLSTDTVSSMSGSYVAPGPRGEADALPSPLAASGAPSEEGEVGVTLPFHSPDVNFLGVRPEERDAEGNDVLEEEDASPTQEDGQRTGSFLSMECDNNNAIASEKGLDNKLGSDVCVPGEWQFTGRELGGRKCLFCLLSPFSSPPPPTPHPRVPGKKTRVVPGFLDTSGRDPDASKGLPLSSVRGTTVGQEGAS
The following text describes a protein:
Function:
Catalyzes dephosphorylation of dihydroxyacetone phosphate (DHAP) to produce 1,3-dihydroxyacetone (DHA). Is the main enzyme responsible for DHA production from catabolism of sugars (glucose, fructose, and sucrose) in C.glutamicum. Displays no activity toward nucleoside monophosphates (AMP, CMP, GMP, or UMP).
Sequence:
MTVNISYLTDMDGVLIKEGEMIPGADRFLQSLTDNNVEFMVLTNNSIFTPRDLSARLKTSGLDIPPERIWTSATATAHFLKSQVKEGTAYVVGESGLTTALHTAGWILTDANPEFVVLGETRTYSFEAITTAINLILGGARFICTNPDVTGPSPSGILPATGSVAALITAATGAEPYYIGKPNPVMMRSALNTIGAHSEHTVMIGDRMDTDVKSGLEAGLSTVLVRSGISDDAEIRRYPFRPTHVINSIADLADCWDDPFGDGAFHVPDEQQFTD
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
Sequence:
MAQTKNLLLFRKWDLSDIEVKDPGLKTAISLRKQILPYTFGRSALKRFNKADVNIVERLINKTMHFGKKYAKNTGRMTGKKTKVLNTVRTAFTIIELKTGKNPVEVLVRAVENSAPNEDTTRIVYGGTVYHVSVDVAPIRRVDLALRFIADAIKESTFSNPKPIEEHMAEQLILAAENDPNAPSVKKKNELERIAQASR
The following text describes a protein:
Function:
Transcription factor. Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription. Plays a role in establishing motor neuron identity, in concert with LIM domain transcription cofactor LMO4. Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking interactions of ISL1-LHX3 complexes with regulatory elements. Involved in pancreas development and function; may play a role in pancreatic cell fate specification.
Subcellular Localization:
Nucleus.
Sequence:
MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLATTVSGPGRGGSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGASTFQLDQWLRASTAGMILPKMPDFSCEAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGTGKGGSEEKTEEELMGPPVSGDKASGRRLRDLRDSDPDEDEDDEEEDNFPYSNGAGAHAASSDCSSEDDSPPPRLGGPGHQPLPQ
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAASDAHNNNKKRSNRRRKKRRTEDFSSSSESSSSSSSESDHEDLDEPEKEISKQDINIDDIDIESDNENSALTNDKGNKLIPQNLSITEKQQLSTVPFTTTSISNITNDNQIKNTPNINEISKNLDQKKTQLNNEFLKIMTTEFGDDLDELRKKPDFTEKSLVILAKTLQSGVNMFDIDVLNGLIQESGNTSNQ