lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Acts as a negative regulator of primary cilium formation (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity).
Subcellular Localization:
Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell membrane. Cell projection, ruffle. Cell projection, lamellipodium. Note=This cytoskeletal protein colocalizes with actin stress fibers and focal adhesion plaques. Expressed mainly in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (By similarity). Colocalizes with PXN at focal adhesions in mesangial cells (By similarity). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). Localized at the lamellipodia, just behind lamellipodia actin ruffles (By similarity).
Domain:
Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus (By similarity).
Sequence:
MESTPFNRQQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEEANMEKRRSNTENLPQHFRRGNLTVLKKKWENPAPGVESLPESTRNSSAEVRHRGDPPPAEVASSSASGVEADQGVCPRPRFSSPPEVPYPNPRIKDTEHLKDHSAESKKMENCLAESRHEVGKPETSENAEASNKIEKYNVPLNRLKMMFERGEPAQTKILRAQSRSTGGRKISENSYSLDDLEIGPGQLSSSAFNTEKSESRRNLEFPRLSDTSIKDRMAKYQAAVSKQSSSTNYTNELKANGGEIKTHKLEQKENVPPGPEVCISHQDGEKVSASENSLAACSTPPEDDSCKSQVKSDVQQPVHPKPLSPVARASSLSESSPPKAVKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKLENEETLERPAQLPNAAEIPQSPGVEDAPIAKVGVLTASMEAKASSQLEKEDKPAETKKLRIAWPPPTELSSSGSALEEGIKVSKPKWPPEDEVSKPEAPEDVDLDLKKLRRSSSLKERSRPFTVAASFRTASVKSPKPLSPPMRKGWSLSEQSEEFGGGVAAERKQMEKASASEKNGSVGKTTWPSKESRGGEAAGRSKEVQDFEIGSENLIENGASLDEGDRDLLQQQSPLEPKSKNWSSFADNTSAKEFTTQKQKSQDVEFWEGEVVEELSVEEQIKRNRYYDEEEDEE
The following text describes a protein:
Function:
Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.
Miscellaneous:
MISCELLANEOUS: Binds copper and nickel ions. Copper ions catalyze the oxidation of reduced thiol groups and thus promote formation of the disulfide bonds required for linker activity (By similarity).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MISGSATASHGRVLLPSQRERRPVSTGSNILRFRETVPRQFSLMMVTKATAKYMGTKMREEKLSEMIEEKVKEATEVCEAEEMSEECRVAWDEVEEVSQARADLRIKLKLLNQDPLESFCQENPETDECRIYED
The following text describes a protein:
Function:
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis. Regulates ER stress-induced neuronal apoptosis (By similarity).
Subcellular Localization:
Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release.
Domain:
The BH3 motif is intrinsically disordered in the absence of a binding partner but folds upon binding. Folds when bound to BCL2L1. Also folds when bound to MCL1 (By similarity).
Sequence:
MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLCAPTAPPAVTAALGGSRWPGGPRSRPRGPRPDGPQPSLSLAEQHLESPVPSAPGALAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQRHRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN
The following text describes a protein:
Function:
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.
Sequence:
MENNETIYLHGDMDLVIVEARRITSTEFVYEDFRRLRHPYVKVYLGEARVAQTTRVRADSQNPMWNEHFELPLAHPVDQEIGAFVPAKRIAIGDLIDEWFPVVGSNGTYTAIRLQITFTPCDINPSYTSGISEDYSVKRSYFPMRHGGKLTLYQDAHVIDGRLPEIGLDYGRKFEQNKCWEDICHTIWEAHNLIYVIGWSIYHKVRLAREDSKQLPNGGDLNLGELLKYKSQQGVRVVLLIWDDKTSHDNCFIKTGGLMKTHDKETRNFFKHSPITCVLDARYRINNVCRIFYSQHQKCVITDTKGHENNRKITAFLGGLDLCDGRYDTPDHQLYDDLNTLFKDDYHNPIFRQRENGPRQPWHDLHCKIEGPAAYDVLKNFEQRWKKATECSEFTRFCKKILGRDDYNLVDIEQISQISSPSGTIPNDHPSLWASKEDDLENWHIQIFRSVDSESVVGFPRNVLAAKEQAIRCAQRFIFIENQYFIGSSFGWTSKRKAGANNLIPMELALKIVSKIRTKERFSVYVVIPMWPEGEPDSDSVRAILYWQGQTIQMMYQIISQELKSANFENAHPSDYLNFYCLGNREERHREESSSDSTSEKYDRFMIYVHSKGMVVDDEYVIIGSANINQRSMAGHRDTKIAMGAYQPHYTCTRKKEHPCGQIYGYRMSLWAEHLGCIENCFKYHENLECVRYINNVAEDNWKRYTADEYNQLQGHILKYPIEIGVDGSVNPLPGHELFPDVGGLVLGNPPIFPPVITALSIERNEIGK
The following text describes a protein:
Function:
ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus. Note=Forms an intramembrane hairpin-like structure in the membrane.
Sequence:
MNSPGGRNDKKKPVTPAAETGPGSPTTPPSTETQVVLAPPSPHKRNLHLFSYPLLAVFSLLRFLAFQLGLLFVWCCELLSRSVMADKGRTVASTAAAQDRPQEPEVVRSYHQQAFQYISLALRVDEEEKDQKEQAVQWYKKGIEELEKGIAVPISGKGEQYDRARRLQAKMSTNLIMAKDRLQLLAKLQADIQGPHSQMEVCSDNTNLPCRNGLLKPEKGAVPKKKDPPPITSNSYSRTKAPPKSGSLGNRIPNCTSVPTSARQAGAHTPSNRGATGKNNTRTNKPATPTTAVRKKDMKNLRNVDSNLANLILNEIVDSGPSVKFADIAGQDLAKQALQEIVILPSIRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFSVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSGGDDRVLVMGATNRPQELDDAVLRRFTKRVYVALPNEETRLVLLKNLLSKQGNPLSEKELTQLSRLTEGYSGSDITALAKDAALGPIRELKPEQVKNMAASEMRNMKYSDFLGSLKKIKCSVSHSTLESYIRWNQDFGDTTV
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAFATAAIQSFLQLNVKRSLYRLLTVGQVFGLVAWDLQPLEPDRPTTKLHWFRKLIRATNQGYCFMIIVAIGTATVLHHSSNTANAFFAIRTLYLTENVIVNVIVLFAMLECQQSRPFYASILKELFELGKNLHDCDASINFPHVEAITDRLLVCAVLYFSTSSLVDWWADYDPSCTFLCHSVLYILPNVINVLALYQYAALQLIVAACYRSVNSVLARYHDHQARPKVRDCAELVETLRRTHLKLGDLTGRVVGRFGPLIVCTVLSSFVVLNLELFNVYKATGRGSKRVWSASEGFRLVHTLLWIGLHGAKILLILYPGHRARVECERTGPTLYEIASRYEAAGRSNSALMKFAGQLLLLHGKRHHCKACGLITLDLTLISKIVAGLTTYLMILIQFDSAFTQGSR
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTSFTVSPPPHIKKKIFIKNLIWSRIVALLPISAAAVYFFGFAALGNIIASILGAVGIEFVIQKAFNKKLTIMDGNAIYLGLLLALICPPTLPAWMIFIGGAFAVGVGKHAFGGIGSYTFHPSLAAWVFLSLAWAQDMLPGTIPILSSFSDLILENGAGFLTDVSPILVLLAGVILILVKYIEWRIPLSYLLTTVILALVLGDPLAYVVSGTFLLGVFFIATETVTSPVTQNGRIVYGILCGFLTVIYGYFSGNYVWGTLYALLLSNAVAPFIELKTLPKPMGGVANE
The following text describes a protein:
Function:
Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA.
Domain:
Contains a N-terminal TRAM-like domain, an iron-sulfur cluster in the central region and a C-terminal catalytic domain. The tRNA-binding site is probably formed at the interface of the three regions.
Sequence:
MRGVIRKLNDDGFGVLKGILVPFSAPGDEIIVERVERVKKRRVASQWKLVRSSPLRVGPRCKAFGKCGGCTLQHLNYDYQLEFKRKKLKRILGFEVEVVPSPKIFGHRNRIDLAITKDGIGFRERGKWWKIVDIDECPVFGKTSREAIERLKEFIEEEKISVWNIKKDEGFLRYMVLREGKFTEEVMVNFVTKEGNLPDPTNYFDFDSIYWSVNRSKSDVSYGDIERFWGKEFIRERLDDVDYLIHPNSFFQTNSYQAVNLVRKVSELVEGEKILDMYSGVGTFGIYLAKRGFNVKGFDSNEFAIEMARRNVEINNVDAEFEVASDREVSVKGFDTVIVDPPRAGLHPRLVKRLNREKPGVIVYVSCNPETFARDVKMLDYRIDEIVALDMFPHTPHVELVAKLV
The following text describes a protein:
Function:
Probable ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase that may be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
Sequence:
MPAAVARSVKCRPHHRLSAPQPPAALELLPRGAQASAGELRATRCLTPPSLSFARASDQGEPPRAPCRSPPSARRARAAVAGREEAGPAASAAAAALLAGAQSRHAIFREELVRRAYYAAEAAHRGQVRASGDPYLQHCVETAALLAELGAGPPVIAAGLLHDTVDDAGLDYGYISEQFGAGVADLVKGVSNLSHLSKLARRNDTASRIDEADRLRTVFLAMEDARAVLIKLADRLHNMRTLDSLPKIKQQCFAKETLEIFAPLANQLGILNWKEQLENLCFKHLYPEQYEELSSNLHQFYNRDMIAAAIRRLEQALQVRGLSYRSISGRHKSIYSIYSKMTRKKLDMDEIYDVHGVRVILENKADCFTTLEVVNHLWPRIPGKFKDYVSSPKSNGYQSLHTVVLSEETLPLEIQIRTADMHLQAEFGIAAHWRYKEGVRNCSSCLPEMVEWVRCVVTWQCETLHIDHPSPPGLGSSPRATCTFPSHSDGCPFSYSKQCDHTGPILVILLENEKMSVQELPPNSKILDLLKRASSYDMQLSLRLNSHAVHNLNQELKMGDVLELIPSTPCKSGGYMRELNQMSDHRLAVSQS
The following text describes a protein:
Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Subcellular Localization:
Cytoplasmic vesicle lumen.
Sequence:
MLLIKKRYALPTFILTFLIYLVFTTLPPGAEKTYIEHYSQPAHDITEIAKDNRIHWTKHAEQYPIADYISLPTASPAPIPKIQYDFPAESWFARIWRKRKQGAVKEAFKHAWKGYKSNAWLRDELSPLSGGYRTSFAGWAATLVDALDTLIIMDLTDEFEEALEALEHIDFSTTDSIQINVFETNIRYLGGLLGAHDLTEGRYPILLKKATEIADFLYGSFDTRNRMPQSRWEWTRSASGQTIHPSGNTILAELGSLNLEFTRMSQLTGDQKYFDAIQRISDHLESAQKETLVPGLWPMMVDAESMRFSDPRYTIGGMADSAYEYLPKEHMLLEGRTQQYQRMYESAIPAIKERMLFRPMTKGGEDILFSGNIYAGTKASRKKVEAQAEHLKCYLGGTIGIGAKVFNRPEELSIARKLTDGCIWAYDIMPSGIMPEVMYLSPCDDLENCPWDEQKWYRDVRARPPPHANIADTEEAAKLLIEKFDLVPGVAEIADARYMLRPEAIESVFIMYRITGDKKYQDAAWRMFNSIEKATRTKYAHAAINDVREEKPKQLDYMESFWLAETLKYFYLIFSEPELISLDDYVLNTEAHPFKRPS
The following text describes a protein:
Function:
Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.
Subcellular Localization:
Cell projection, dendrite. Cell projection, growth cone. Cell projection, lamellipodium. Nucleus speckle.
Sequence:
MATEPEAAEPVVPSLVDRYFTRWYKPDVKGKFCEDHCILQHSNRICVITLAESHPVLQSGKTIKSISYQISTNCSRLQNKVSGKFKRGAQFLTELAPLCKIYCSDGEEYTVSSCVRGRLMEVNENILHKPSILQEKPSTEGYIAVVLPKFEESKSVTEGLLTQKQYEEVMVKRINSTTATS
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase involved in the elongation of N-glycans and synthesis of the second mannose residue of O-glycans. Catalyzes the transfer of mannose to mannose and alpha-(1,2)-mannobiose as substrates but hardly transfers mannose to alpha-(1,3)-mannobiose or alpha-(1,6)-mannobiose. Transfers the C1-hydroxyl group of the mannose residue from GDP-mannose by dehydration-condensation with the C2-hydroxyl group of the terminal mannose residue. Required for the maintenance of the fungal cell wall and full virulence, but not for the adhesion of conidia to host epithelial cells.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSSGPKYMRYLLFAAVGLAVFFLISRSSIPIPENIGSKLSPANYKDTISQSDKAHNDAPPKPPVKETPGSANTAPVGRVNATFVTLARNSDVWDIAKSIRQVEDRFNRNYHYDWVFLNDKPFDDTFKKVTTSLVSGKTFYGEIPKEHWSYPDWIDQEKAKKVREEMGQKKIIYGDSESYRHMCRYESGFFFRHPLMLNYEYYWRVEPSIELYCDISFDPFKLMKEQNKKYSFVLSLYEYYDTIPSLWDSVKKFMGNHPEHIAEGNAMGFLSDDGGKTYNKCHFWSNFEIGSLEWLRSKQYLDYFDALDHDGGFFYERWGDAPVHSIAAGIMLKKEEIHFFNEIAYYHIPFTHCPTSEQMRLDLKCHCNPSENFDWKGYSCTSRWFQINDMEKPEGAEEQS
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MLRHLSIKDFAVVRATELEFGPGMTVVSGETGAGKSLMVDALGFLSGLRADSGVVRHGADRAELSAEFQLPAEHPGLTWLADNELDDDAQCQLRRIIRADGGSRAWINGRPVTSSQLSDLAARLVEIHGQHEHQALMARNSQLALLDAYARNSAQREQVRQASQRWQALLDERDALSAQGDVSDRIGFLEHQLAELEREDLDPAAIAALDTNHRRQAHATALIGACESVVQQLNGDEGPSALGLLQDSRHDLARVAEHEPRLGEVDALLDSAAIQIEEALALLDRVRDDLDADPTQFEAMERRLGRLHDLARKHRVSPDELAAHRDHLTAEVESLRGADERLQQLDKHIEAAIGVWQGAASVLSASRQSAAQALSAATTTLIGELGMGGGQFLIQLQPQETLRPDPNGAERVEFLVAANAGQPPRALRKVASGGELSRISLAIEVAALGLDSVPTMVFDEVDSGIGGAVADIVGQKLRALGEERQVLCVTHLPQVAAKGHAHYRVSKAPVDGMTQSAVELLGPQARQEELARMLGGVEVSKEARAAARKLLQSA
The following text describes a protein:
Function:
Putative transcription factor involved in halotolerance.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MENQGGDYSPNGFSNSASNMNAVFNNEITGRSDISNVNHQTGTPRLVPETQIWSMPVPDQLMTMPNRENTLMTGSTIGPNIPMNVAYPNTIYSPTEHQSQFQTQQNRDISTMMEHTNSNDMSGSGKNLKKRVSKACDHCRKRKIRCDEVDQQTKKCSNCIKFQLPCTFKHRDEILKKKRKLEIKHHATPGESLQTSNSISNPVASSSVPNSGRFELLNGNSPLESNIIDKVSNIQNNLNKKMNSKIEKLDRKMSYIIDSVARLEWLLDKAVKKQEGKYKEKNNLPKPARKIYSTALLTAQKLYWFKQSLGVKASNEEFLSPISEILSISLKWYATQMKKFMDLSSPAFFSSEIILYSLPPKKQAKRLLENFHATLLSSVTGIISLKECLDLAEKYYSESGEKLTYPEHLLLNVCLCSGASATQSIIRGDSKFLRKDRYDPTSQELKKIENVALLNAMYYYHKLSTICSGTRTLQALLLLNRYFQLTYDTELANCILGTAIRLAVDMELNRKSSYKSLDFEEAIRRRRMWWHCFCTDKLYSLMLSRPPIVGERDMDMLTDQNYYEVIKTNILPDLIDKKEDLDKITDVNSALNVVVNFCQHISLFISYYVSKLVSIESKIYSTCFAVRSTLDLSFDAMLDKIKDLNDSLNNWRDNLHVSMKLKSYKQYLSVLYAQKSQENPALSFEIACSRVLNCHFRALYSKVILSMMTTSLLIDNERLYKGSRHDIPQLFILFSSQYLNASKEMLQLFQGINYQAHMYNEVMYQFSTAMFVLFFYVVDNMNDLKKKGEVKEIIDILKKSYDRLVGENDEQLLFDNVKWNTLIVFYSHFLKYVLQRYHALNDSTSIFDSKPYDETITKVIMHSRKIKDETVDQLIMSLKSYGSLHSLQKGNEADLADDGLNTNDISSEDFAEEAPINLFGELSVEILKLLKSHSPISNFGDLSPSSNRKGISDDSSLYPIRSDLTSLVYPIHSSDTGDTLSSGLETPENSNFNSDSGIKEDFEAFRALLPLGKLIYDRDYSFVNTFRDYE
The following text describes a protein:
Function:
Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes in female and male zygote pronucleus. Associates preferentially with the paternal chromatin during zygote development.
Sequence:
MAEPTVVIAPTTVPREDLGHGEPLLMTAKQVKKTPGLEREGWWRLTITDTPIPGTYHFRTFTEEALLNPVKITYNFKNEGRKKLPLVLRNDPVPTDLPQYSPPDFLELLKKQTASYSFKDKPRADPSTLVDKDESLHLCPGQYEVLPAPVPKSPARSFVFRSSVQRFPPNYFTPHEGPGPGDYELKASPKGSITSCFRSKVPRFLPVSSKTPGPGAYTSSRQFPKQSSTIAKMGREHSLFFNNTIGF
The following text describes a protein:
Function:
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MLELNFSQTLGNHCLTINETLPANGITAIFGVSGAGKTSLINAISGLTRPQKGRIVLNGRVLNDAEKGICLTPEKRRVGYVFQDARLFPHYKVRGNLRYGMSKSMVDQFDKLVALLGIEPLLDRLPGSLSGGEKQRVAIGRALLTAPELLLLDEPLASLDIPRKRELLPYLQRLTREINIPMLYVSHSLDEILHLADRVMVLENGQVKAFGALEEVWGSSVMNPWLPKEQQSSILKVTVLEHHPHYAMTALALGDQHLWVNKLDEPLQAALRIRIQASDVSLVLQPPQQTSIRNVLRAKVVNSYDDNGQVEVELEVGGKTLWARISPWARDELAIKPGLWLYAQIKSVSITA
The following text describes a protein:
Function:
Signaling peptide involved in the regulation of lateral organs separation.
Subcellular Localization:
Secreted.
Sequence:
MGDCRPLGFLIGLPFALVALVLALVGAVIWIIGTVLSCLCPCCFCFAALANFAVDLIKLPIKVLRWFTHSIPC
The following text describes a protein:
Function:
Converts protoheme IX and farnesyl diphosphate to heme O.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLSRHIFQCSRLGFAPSTSQAVFHTSTVNSVLPRAKPLDEEMPAPAALKTLESKKSRPDFQILDLSSGKRHKKDIDIIVTDQYLQQWYKMETKSLAADYLALCKSKLSLFVASTATCGFLMAPVPVAAAPLAAATIGTFLLSSAANSCNQLLEAPYDAQMRRTQSRVLVVHRFSPLHAFTFAGVTGMAGIGLLAYYANPLAAALGALNWFIYAGVYTPMKRSHIGCTWAGAVVGAIPPLMGYAAATGHLDPAAWCLATILFSWQFPHFNGLSWNLRGDYSKAGYRVMCVTNERLCRVTSIRHSVALLGLCSIAAPHTDLTTLTFAIDSLPVNAYLVYLSYKFYKAPDAKNSRKLFFYSLLHLPLIMLLMGISNYGRNEQQKEPVMERITNGYNKMIDSVKSLTTSSTA
The following text describes a protein:
Function:
Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLARDELIYTLKGLIGDSILAIIIAGDNEPLAPIVGPVGWGTAIFVAVTIAGGVSSHLNPAVTLALASTKKFPINKVPLYFAVQYLGAFVGAALVYLLYHDQIAHFDGGVRQITGKHGTAPIFATYPREQISTLTCFFDQLVGTGILMLTAEAITDPRNFGGMPKHLHPLALGFMIMALIFGFSYNCMAPLNPARDIGPRIFTAIAGWGTEVFTYRNWNYIWVPIFGPHIGAIIGAWIYKVGIGDNFPDDEPKLRAAESGVQLVVYQPGAEQPVPEAPAPVP
The following text describes a protein:
Function:
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore.
Domain:
The entire WD repeat region is required for the interaction with ORC complex components, as well as for association with chromatin and for binding to histone methylation marks.
Sequence:
MSKITADVLLKEGLPKSIHLKDLKKLNLSKMHLEMKDIDPKLFSQMVNLDELDISHNTLSELPDNLGLHNLRILNFADNHVEDVTVLKQFPNLEEVIYEDNIYLTVSDNYKVFCLLPKLRRLNNKDITSLANHVRFVNHRELSNRVEAHWDSKFKDNLPDKPSSQKINAVAKDFIKSVVNNIKYGPSSLKEFVRWKALGCSGKKRDSADDCTEGSPTKRTRIQHELQSIPLSPRKSNRLQNSPLSLTPIKRKQETSTQGTPSKSTETKSPKVALKSTPSKKQSNESSAKINGKQKLSLTPKIIQKALDNIEPLHFLQCHSKNNSCEDFKTQLWACAFEPILDSSSPKAVATCGGDSVCIIDCETGKVMKKYKVTGEEFFTLVWTTLTMIGKDEQKRKINVLAAGGKHGVVRIIHAKVSLCYGEIKAHKKAISIMCFSPKQDTFLFTGSYDKRIILWDIGVPDCDYNFRPSQLLTLDTTSVPLRMCLVPSCPDEFLVAACEDGCFAWDIRLDKKQGRRSYEVELNFPIYKEERKDNDFHVIDSLAFLNEDIIASKSVMQGSIYLWSWEKTLKTRKTKNVKKLDAVILAQMKWSSSETPYLVLSTSPERYCVFCGDEDGKIWIYDLDSCKADLQRGKLCSVVKEPTKILSWPILFSPKEKVEKTLINVVTVDPTMEYLVALTDINIVSIWKIK
The following text describes a protein:
Function:
Involved in transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDRMEIDDQAGIDFVTESINSERARNRWSTSHIPSLSEINPSSFQSPSPSPFASSTSLASKPARYSKPLGLFVLDTNFLLSHLSLCQNLIEFLTARCPRLVVVLPWTVLQELDGLKSESSSTCGYLARQAHNFLLQCFRSNVSSLRGQKVHEHCSSTEKGDDAILDCCIYYQEEKLIPAVLLSDDKNLSIKAAVHHIQSLSFSKGLEAASIVQTSFPSAFSSNSENLENLSMDIDLTVSQPLATATNHRNQGASTVDIPMDRTHDNSIWASRYAHFPPYDKKKDTTRSAADYIPYTYTALTKEEILHASHPRACKLLDQITKIMVEETAFLLSRHLLKLWGDYDLAMTKLLASPQFPPQNINDVGHELYIHWYTCFDGYLPAQERSNLKSKAELWNEWMLWAERGIGIGPKNQEELQTYVTFWSNIWTLLSRREILGDQASTYIGFREQNIEKWVERSGRERILS
The following text describes a protein:
Function:
May be a proton symporter involved in the uptake of osmolytes such as proline and glycine betaine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWRHANVPVTPQEVVPMSSPATAPPAPNNLKRIVAASLIGTTIEWYDFFLYGSAAALVFNELFFPDSDPLVGTLLSFLTYAVGFAARPVGALVFGHYGDRLGRKKLLVLSLLMMGGATFAIGLLPTHATVGTAAPVLLTVLRLVQGFALGGEWGGAVLLVSEHGDARRRGFWASWPQTGAPAGQLLATGVLSLLTAVLSDAAFNSWGWRIPFLLSGVLVMVGLWIRLSVDESPVFKQALAQAESRKAKAEPLPLVAVMRHHWRDVLIAMGARMAENISYYVITAFILVYATTTADVSKQTALNAVLIASAVHFAVIPAWGALSDRIGRRPVYLLGAAGVGLWMFPFFMLIDSGHFGSLLLAVTVGLVLHGAMYAPQAAFFSEMFATRMRYSGASIGAQFASVAAGAPAPLIATALLSEYDSSTPISLYVIAAAVLTLFAVGVARETRHRDLAEVDSVAGDADEDGPVSDSRAQRARIV
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSSYFVNSLFTKYKSGDTLRPNYYECGFAQDLGTRPTVVYGPGTGATFQHAPQIQEFYHHGASTLSAAPYQQSPCAVTCHGEPGNFYGYDALQRQTLFGAQDADLVQYSDCKLATGGIGDETDNTEQSPSPTQLFPWMRPQAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKSEQEQIEKEKREKEQASGTQSAGEDCDKAKQM
The following text describes a protein:
Function:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Required for spermatogenesis and oogenesis.
Subcellular Localization:
Chromosome. Note=Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema and decreases at zygonema.
Sequence:
MSEAGNVASGLGLPGEVSQWSLKRYGRFMLLDNVGSPGPSSEAAAAGSPTWKVFESSEESGSLVLTIVVSGHFFISQGQTLLEGFSLIGSKNWLKIVRRMDCLLFGTTIKNKSRMFRVQFSGESKEEALERCCGCVQTLAQYVTVQEPDSTTQELQQSQGPREAGESQGKDPLQQGPSLTLEQHVCMAAGAGVLQERTSVTHRAQSILAPEKLTLAYEGSSWGTEELGPFLRLCLMDQNFPAFVEEVEKELKKITGLRN
The following text describes a protein:
Function:
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (Probable). This subunit forms the outer membrane channel (By similarity). Among its substrates are PrpL, elastase LasB, chitin binding protein D (CbpD), aminopeptidase PaAP, and metalloprotease ImpA.
Subcellular Localization:
Cell outer membrane. Note=Most of the protein is in the periplasm which it traverses to contact proteins of the cell inner membrane.
Domain:
The N0, N1, N2 and N3 domains are periplasmic, while the secretin and S domains form a channel that is partially inserted in the outer membrane. The N1, N2 and N3 domains each form a periplasmic ring; the N0 domain was present but not resolved by electron microscopy. The secretin domain forms a double beta-barrel structure; the outer barrel has a diameter of about 140 Angstroms while the inner barrel forms the central gate with a small pore in the closed state. Isolated N-terminus (domains N0, N1 and N2) assembles as a hexamer of dimers (i.e. dodecamers). The N0 domain probably moves during export. It has been suggested that the C15 symmetry of the C-terminus may transit to a C6 symmetry by displacement of 3 of the N-terminii (Probable).
Sequence:
MSQPLLRALFAPSSRSYVPAVLLSLALGIQAAHAENSGGNAFVPAGNQQEAHWTINLKDADIREFIDQISEITGETFVVDPRVKGQVSVVSKAQLSLSEVYQLFLSVMSTHGFTVVAQGDQARIVPNAEAKTEAGGGQSAPDRLETRVIQVQQSPVSELIPLIRPLVPQYGHLAAVPSANALIISDRSANIARIEDVIRQLDQKGSHDYSVINLRYGWVMDAAEVLNNAMSRGQAKGAAGAQVIADARTNRLIILGPPQARAKLVQLAQSLDTPTARSANTRVIRLRHNDAKTLAETLGQISEGMKNNGGQGGEQTGGGRPSNILIRADESTNALVLLADPDTVNALEDIVRQLDVPRAQVLVEAAIVEISGDIQDAVGVQWAINKGGMGGTKTNFANTGLSIGTLLQSLESNKAPESIPDGAIVGIGSSSFGALVTALSANTKSNLLSTPSLLTLDNQKAEILVGQNVPFQTGSYTTNSEGSSNPFTTVERKDIGVSLKVTPHINDGAALRLEIEQEISALLPNAQQRNNTDLITSKRSIKSTILAENGQVIVIGGLIQDDVSQAESKVPLLGDIPLLGRLFRSTKDTHTKRNLMVFLRPTVVRDSAGLAALSGKKYSDIRVIDGTRGPEGRPSILPTNANQLFDGQAVDLRELMTE