lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (By similarity). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons.
Sequence:
MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVLWEKGGQQLVASERLSFPEDGAEHGLLLSGALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAPEPEPQSSECPPPPPGTGEGAPVFLTGPQSQWVLRGAEVVLTCQVGGLPEPKLYWEKDGMALDEVWDSSHYTLEPDRGASDGGASLTLRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPHENPPQDPDEPPVRVIEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHLEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIVVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLVIHRLKADDDGVYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETQEAGVQGCWSRDGEELPATCQSSCGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPVLVEMFKGQKNTVLLTWKPPEPPPETSFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPTEGDYRFRICTVSEHGRSPHVVFNGSAHLVPTARLVSGLEDVQVYDGEDAVFSLDLSTIIQGSWFLNGELLKNDEAEGQVEPGALRYRIEQKGLQHRLILQTVKHQDNGALVGFICPGVQDSAALSIQESPVHILSPQDKVLLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESESLVVKMDGRKHRLILPEAQVRDSGEFECRTEGISAFFSVTVQDPPVHIVDPQEHVFVHAITSESVMLTCEVDREDAAVHWYKDGQEVEESAVIVLEKEGPRHRLVLPAAQPSDGGEFQCVVGDERAYFTVTITDVSSWIVYPNGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVLESPALLLEKEDTIRRLVLPSVQLEDSGEYLCEIHDESASFTITVTEPPVRIIYPQDEVTLHAVSLECVVLTCELSRVDAPVRWYKDGLEVEETEALVLQSDGPRRRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPVARSLDLQFGAPGHVELRCEVAPAGSQVRWYKDGLEVEVSDALQLGAEGPARTLTLPHAQPEDAGEYVCETRDEAVTFNVSLAELPVQFLAPEAVPNPLCVVPGEPVMLSCELSRASAHVSWSHNGNPVKQGEGLELRAEGPRRILCIQAADLAHTGVYTCQSGTAPGAPSLSFNVQVAEPPPVKLVSELTPLTVHEGDDATFQCEVSPPDAEVTWLRNGAIVTPGPQLEMVHSGSSRTLIIRGCQLKDAGTVTARAGATDTSARLHVRETELLFLRRLQDVRAEEGQDVYLEVETGRVGAPGAVRWLRGGEPLPLDSRLTTAQDGHVHRLSIHGVLLTDQGTYGCESHHDRTLARLSVRPRQLRELRPLEDVTVHEGGSATFQLELSQEGVTGEWAQGGVRLHPGPKCHIHSEGRTHCLVLSGLGLADSGCISFTADTLRCAARLTVREVPVTIVQGPQDLEVTEGDTATFECELSQTLADVIWEKDGQALSLSPRLRLQSLGTRRLLLLRRCSSSDAGTYCCAVGTARSGPARLTVREREVSVLGELRSLSAREGDSATFECTVSESETTGRWELGGRALRPGGRVRIRQEGKKHILVLSELRTEDTGEVCFQAGPAQSLARLEVEALPLQMCRRPPREKTVLVDRRAVLEVTVSRPGGHVCWMREGVELCPGSKYEMRSHGTTHSLVIHDVRPEDQGTYSCQAGQDSADTQLLVEGDD
The following text describes a protein:
Function:
Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.
Subcellular Localization:
Cell envelope. Cell membrane; Lipid-anchor, GPI-anchor. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNCQNWAIGSALLLALVQLAYSSVGTPRITRVGRYLYDANGNRFYIKGVAFEAPKLPNVNRGGLNRADLIDPLADINACNHAIKNFKRLKINTIRVYSYYPEIDHSACMNALEKSGIYVIADINPPLSGSINKASHTWDVDILTQYIHRIDSLRSFPNLLAFNIGNEVITNSEHLEAGPYIKARARDVKLYLKSVNSTALVSYASADGKKLSAELARFLSCNSGGPSAELDLFGVNNYRWCGDSNFESTHEELTLEFQGLTIAAFLSEFGCLNPGKPRGWVEVTALFSTLMSDLWSGGVAYNYYPTAHGYGLVDNVEGKWIRNKDFENLSQRYHLVKPPNMPKLSSLVVPKQKCASTNVNSFAITSVLPPQPNVEACNCLDHAAFSCQVRKDASPMVMSELLDSTCKAIGNSIPPGSGEGCGLISSSPNKGVYGILSACSSATRLNYAMTRYFINAGLDKKACDFSGNATVQNPIKLKSAGEVDREVGRCFEINANNSILPNKKTTGASKNTPAQINSNAYKNSISGVRGQSGTQSSASSWRPSESDAFGVGKAANC
The following text describes a protein:
Function:
Channel-forming protein essential for import of protein precursors into mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MGNVVAMATSPPYWRKHKKRVPLPNPGSFDELHRSCKEVFPQQMEGVKLIINKPLSSHFQVSHSIHMSTVGQSSYHFNAKYVGDYQPSPTETFPMLTGDVDNAGSLNAQIHCLLADRFRSKAVFQTYRSKFLTWQVDGEYRGDDCTVTLTLGNPDILNESVILVTHFLQSITPRLVLGGELVYHQRMGEEGAIFTMAGKYSAPNWVATLNIGYGGAHASYYHRANEQIHVGVELEANTRLQETSFAFGYHLDIPKANVVFKGSVDNSWCVGGILEKKLPPLPVTLALGAFMNHWKNKFHCGFNIMVG
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSKAILTALPQPVTLTTVQFAFVSGWCLLLAAAARRFPRLKQTLPFLKYGIRSPSKDLIMATLPLTCFQIGGHILSADATSRIPVSLVHTIKGLSPLLTVGAYSIFLGITYSLPTYLSLIPLTVGVILACSADFNANFIGLLSAFASAILFVVQNIVSKQIFNDAAAAEKDGLPPSRFTKPDKLNLLCYSSGLAFLFTLPLWLWSEGFTLLGDFLHDASIELSDRPGSFDHGRLLLEFLFNGTFHFGQNIVAFVLLSMVSPVTYSVASLIKRVFVIVFAVVWFGKPITKVQAFGLCLTFVGLYLYDRTSDAKRVDKRAKAMQAKGQGTLLPLATDVKSRAGFMASPSSMSAGTAAHPISSIAEARDEKRDDDATGSRRHEAGNGYLPPGTKAEETWRPHGMNGRTGIGVS
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Sequence:
MARSLSLLLLLVACFLVAGATAARPAPSTSGAAAISSFVRSWCAGTKYPALCDATLAPYSAAVGASPAKLAWAALTVTLSAARNATSAVRSIAARSSSSHLPPVAAEAAGDCASELGDGVDALRRCVDAMARVAVGEESSSTAAAARRKVRFEVDNVRTWASAALTDDNMCMEGFKGEAAGGGGAREAVRGHIMGLLHLTANALGILNAMAKQI
The following text describes a protein:
Function:
This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore-forming protein). The inducer is deoxyribose-5-phosphate.
Sequence:
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKRRAAKLAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQTLNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIVVSDCCPEDEYVKYAQTQRIKLMY
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
Subcellular Localization:
Nucleus. Note=Detected in the splicing complex carrying pre-mRNA.
Sequence:
MVVMARVPRSERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALKLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFISRYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYDRATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIREMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPPRAQSKIFFVRSDASREELAELAQQANPEEIQLGEDEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED
The following text describes a protein:
Function:
Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence. However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLYKSSDRPAHKVSMLLLCHALAIAVVQIVIFSESWAFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSAPTLYLPVLAWVFVLPLL
The following text describes a protein:
Function:
Transcriptional regulator that plays an important role in general stress response.
Sequence:
MSIQQIIEQKIQKEFQPHFLAIENESHLHHSNRGSESHFKCVIVSADFKNIRKVQRHQRIYQLLNEELNHSIHALALHLFTPEEWKAQNETVPHSTKCAGIGR
The following text describes a protein:
Function:
3beta-hydroxysteroid dehydrogenase that converts 3beta-hydroxysteroids to 3-ketosteroids, an essential step in the production of dafachronic acids from cholesterol. Catalyzes the dehydrogenation of lathosterol (5alpha-cholest-7-en-3beta-ol) to lathosterone (5alpha-cholest-7-en-3-one), a step required for maximal biosynthesis of Delta(7)-dafachronic acid. Dafachronic acids act as ligands and bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth, they can also regulate C.elegans lifespan.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLELIYILPLLCFVYFLFRRFVLENFYVESSGKYVMITGCDSGFGRLLATSLLDKHVNVFAACFTQQGMASLHSEWKLKKGPKGQLYTLQLDVTSQASVDSAKSFVTKILKEQNSKLWGLVNNAGIFSIHGPDDWCSVDEYASSLNVNTLGAVRMCHAFVPLIKKSRGRIVTMGSTAGRLHGLYVAPYVTAKFAVEAYMDCLRLEMRPFGVSVHILEPGCFKTELLNNDAQRMRIQKIWNSLSVETKEEYGEDYRNDFERAWEAGVNVVANPNIGWVVDCYSHALFSWWPRLRYCPGWDAIFMFIPLSIFPTALQDWILAGLYKLNPGPSLTPAVLVKNKKRRSAIQWIQFLSQIAIIPLLYTIFFVKNTQKQTVETSTHHHNVTVSE
The following text describes a protein:
Function:
Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20.
Miscellaneous:
MISCELLANEOUS: Present with 1430 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MQIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSDDTFKTNAAIDQTIELNASSIYIIFDYEN
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MASPPQPKQLVLATSSTDPDLAALDLRTGVEDYVIHGSRPGCLGPLHLVWRTFASALALPALGRSPQLPTASLPSLKLFPLAITLGPSTSTTGTSRKWSSRACALLKGKIPIPSQSTWFFSFMCQGGDFTRGNDTGGESIYGARFTDENLKLRHTGLDVLSMANAGPDTNDSQFFICTAQTP
The following text describes a protein:
Function:
Phosphatase which may dephosphorylate receptor let-23 and thereby regulate cell fate during the development of the vulva and the excretory system. By inhibiting let-23 signaling prevents the establishment of a primary cell fate in the descendants of vulva precursor cells P5.p and P7.p. Similarly, may prevent duct cell fate in ABpr precursor. Also dephosphorylates the beta-integrin subunit pat-3, probably within the alpha pat-2/beta pat-3 integrin receptor complex, which leads to down-stream effects including the negative regulation of let-23 signaling and vulval induction. In particular, by dephosphorylating pat-3, promotes the recruitment (by unphosphorylated pat-3) of the cytoplasmic adapter protein tln-1 to the plasma membrane of secondary vulval precursor cells. This promotes the linking of focal adhesion sites to the F-actin cytoskeleton, and also acts to restrict the mobility of the let-23 receptor on the plasma membrane of vulval cells thereby attenuating let-23 signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Note=Localizes in intracellular punctate structures in vulva cell precursors which partially colocalize with let-23.
Sequence:
MIRWKYELHSLIWLFLVLHLSKCQSDSLTTSAEQHELFAIKKDSLSPWSQILVSLPRRHPLYQSFAAKIQDVTENISDEVRDSNKTFVSSDDAPYSIRIHALRAGHRYSIAIHGQKDGSTSLIKEESVVMDPRAPDFRSMDSDIQVAEHNITMRTIKNDSYLQDSFSIEYRQINPDKKFPVLQILDIPEQKNLEFYLGNLNSGFDYSVRVIAHKDGMSSRPWISTLTTKPSPLKEVNINQNAGSCVEVSWQNDEFSGADFYTIQYSLQSTPNNSTNMTIPSTESSISICDSMLQGEAYQIIATVQKGGQVSEPLITKFQLRPLPPIDFRVRADLKRGKYKLLAELPTSSKIDKCQITVAGDEAERSVNYANIEQTKSGHKICWFNFALSPGERFDFSISSMANESASQKLQKSIVLTPAFDFNAFGLTLQESNGGIELIWPKSEVFMTRVKDIWNKVVGAESLLNMRITPIGNNDETDKTLKFETSPKNIDPVFAKNLVKGACYRVQLFTVTKTGIISETRHNETIRMSSPAVNVSLESVTRSSATLRIVFSTHHDSTSISNCQMHIVVRDMNGKSVFDKRMQLTATFAPLLNLDGLSPFHKYTVNTQIICGSGSSETPQCPAATRTMRQLSFSTRQDKPAAVQDLKVEPLNSYSVMLTWLPPALPNGILTHYAVNVTKIGSDETRTIDVGVSSNRSDHTVQVVIDELFGGHTYSFSVRAVTEAGFGENSPVVPTVSMPLMAPPVPTVAPMIMKESVGSHNMIVRFPTTMFDNRNGEIKQFAIIVSETTADESINRWIESDNGTYTWQQVQRFDVWPSYVAKLQDIQKVKQDVDVSIFEELGEDETCLEVRADRICNGPLRSASKYRVRIRLFTSPTLFTDSPPSQVMTTGSATPAIPLLTVVAVLIVIAFVGIVGTIFLFFWNRTKKARLAAAAFKNGPSKEKESQWEALKMMMAERAADCLAKLGLDATTPPPSSTTSSNSPTSTSTTMTDCGSNPHLGAPNAGGHRRTRSLRERTGVEHRLERLSSGPVHRTPLYTVVTGANTNKSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGSSPSPTSTSTGAHHNAGFVQDGQMIVESGF
The following text describes a protein:
Function:
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MKSKSWNSIGRWIIYGLLLIVFVGPYWGIIATAFSGAPVKPGELLAWPNQFSWDNFIFAWMDIGVWQYLLNSIIVVFFGTVLQVSVSALAAYALARKKFVGVSLTSLIILSTMMLPEEVIAIPLYMIINWQLPVIDASLYNSYLGMILPIVGWAFSIFVLTEFMAAIPKELEEAARIDGASEWQIFFHVILPLVKPALGTVVTFGFIMIWDQYLLPLIVVNQDSLNTIPVILGTLRTDESITPNIFIAITLLAMLPSIIVYLGLQKHFNRGIMSGAVKG
The following text describes a protein:
Function:
Bifunctional wax ester synthase/diacylglycerol acyltransferase (By similarity). Involved in cuticular wax biosynthesis (By similarity). Required for petals development, probably by mediating the production of fatty acids at the plasma membrane in the petal epidermis acting as lubricants that makes petal elongation smooth in narrow space between the sepals and the anthers inside floral buds.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MGEDKKTARETVEEEPLSPCSRLFNSPDFNCAIIVTMGSKVKGDTPAIIHGLEHTLVNHPRFSSILEMNNGKKPRWVRTKVKVEEHVIVPDVDPDIENPDQYLEDYISKLTTIPMDLSKPLWEMHLLGVKTSNAESYAILKIHHSLGDGMSLMSLLLACTRKTSDPEALPTVAVHKKRFGPSCNSGFFNKIWWLFVGLWFILRLLFNTFVDILMFALTIFVLRDTETPLLAKPGSELIPKRFVHRIISFDDVKLVKNAMKMTVNDVLLGVTQAGLSRYLSRKYDQEATPKSKESMRRIRLRSAIMINLRPNAGIEALADMMAKKSKCRWGNLFGYILLPFSVGLETDPLEYVRQAKATIDRKKHSLEAVFSMAFFKLILKVLGLKASVVLVRKVIHSTTLSFSNVVGPKEEITFHGHPLNYISPCVFGHPHALTLHFQTYANKVIISVTADPTVIPDPHKMCDDLVESLKMIKAAVLERGLYEIEV
The following text describes a protein:
Function:
Cysteine protease which cleaves native host hemoglobin and globin in the food vacuole during the asexual blood stage. The binding to host hemoglobin is pH-sensitive and only occurs at acidic pH. Cleaves ankyrin and protein 4.1, two components of host erythrocyte membrane cytoskeleton required for the stability of the erythrocyte membrane, and thus may be involved in parasite release. Preferentially cleaves substrates which have an arginine or lysine at the P1 position and a leucine or phenylalanine at the P2 position.
Subcellular Localization:
Vacuole. Membrane; Single-pass type II membrane protein. Note=In trophozoites, localizes to the digestive (or food) vacuole, an acidic vacuole where host hemoglobin is digested. Localizes to the cell membrane prior to its trafficking to the food vacuole.
Domain:
The propeptide is not required for the folding or final catalytic activity of the active enzyme.
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYKGNENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICTDDDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
The following text describes a protein:
Function:
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFENLLEKREKTNFDPAEWGAKVDDRFYNNHAFKDEPPEKSETQKIQPEKVAIEKETMPQETVKEKETQVSFVEEPTEEPQKEEEEEEEDEEDLEGLLVREGMQDAAVKIQAVFRGHKTRKEYLKKRDSTDETADENNE
The following text describes a protein:
Function:
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
Sequence:
MTEIPSSFVLPDPEWIYRVGIGQDSHRFLPDEDPKPCILGGIIFENTPGFEANSDGDVVFHAICNAFSSVTHKGILGGLADELLKTKGITDSVVYLQEAVASLKPTQRVSHLAITIEGKRPKLLPQLPSMRKRIAEVLHIPLDSINITATSGEGLTAMGQGYGVQCFCVLTIMEYCRY
The following text describes a protein:
Function:
DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication.
Miscellaneous:
MISCELLANEOUS: Present with 1040 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNKELASKFLSSIKHEREQDIQTTSRLLTTLSIQQLVQNGLAINNIHLENIRSGLIGKLYMELGPNLAVNDKIQRGDIKVGDIVLVRPAKTKVNTKTKPKVKKVSEDSNGEQAECSGVVYKMSDTQITIALEESQDVIATTFYSYSKLYILKTTNVVTYNRMESTMRKLSEISSPIQDKIIQYLVNERPFIPNTNSFQNIKSFLNPNLNDSQKTAINFAINNDLTIIHGPPGTGKTFTLIELIQQLLIKNPEERILICGPSNISVDTILERLTPLVPNNLLLRIGHPARLLDSNKRHSLDILSKKNTIVKDISQEIDKLIQENKKLKNYKQRKENWNEIKLLRKDLKKREFKTIKDLIIQSRIVVTTLHGSSSRELCSLYRDDPNFQLFDTLIIDEVSQAMEPQCWIPLIAHQNQFHKLVLAGDNKQLPPTIKTEDDKNVIHNLETTLFDRIIKIFPKRDMVKFLNVQYRMNQKIMEFPSHSMYNGKLLADATVANRLLIDLPTVDATPSEDDDDTKIPLIWYDTQGDEFQETADEATILGSKYNEGEIAIVKEHIENLRSFNVPENSIGVISPYNAQVSHLKKLIHDELKLTDIEISTVDGFQGREKDVIILSLVRSNEKFEVGFLKEERRLNVAMTRPRRQLVVVGNIEVLQRCGNKYLKSWSEWCEENADVRYPNIDDYL
The following text describes a protein:
Function:
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate.
Subcellular Localization:
Mitochondrion.
Sequence:
MAGVGLAAVPAWVPCRRWGLAAVTFGFHHGLSTLLARKTERAPQWLRACRHKTSISFLSRPDLPNLAYKRLKGKSPGIIFIPGYISNMNGTKALAIEEFCKSLGHAYIRFDYSGVGNSDGNLEECTVGKWRKDVLSIIDDLAEGPQILVGSSLGGWLMFHAAIARPQKVVALVGVATAVDGLVTQFNQLPIETKKEIEMKGVWPMPSKYSEEGVYRIQYSVIKEAEHHCLLHSPIPVKCPVRLLHGMKDDIVPWHTSVQVADRVVSTDVDVILRKNSDHRMKEKADIQLLVYTIDDLIDKLSTIVH
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Appears to play a role in spore wall formation.
Subcellular Localization:
Ascus epiplasm.
Sequence:
MDPFAGTGQSKSYRTFGNVFQRLSMSGNPKPLAKKPLLLPEASKAIEFWNYRDVIGGEEAEQERNERASRIAISRIASSRSSIPEYRQAIMQHLTKHVQQLDQLAEW
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSAIFNFQSLLSVLLLLICTCTYLRSLFPSIVDRNKTGMLGLFWKFARVGERKSPYVSFACLVMAVSILFWS
The following text describes a protein:
Function:
Involved in reticulocyte adhesion. Specifically binds to human reticulocyte cells.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MKRGICLAALLCLFNYLGAGHGENAEEDIRNSEGKVNFFSLDSNLKKNKKSKHNRVKRRNAKISNFLSQKAYVKETDNASGKDAEGSRPSHDSSFVNLNGHVDGKSLSYSVHVKESTPHSTTRESTEKGKENEKIQGVLSSFVQSQEGGESDDLEGMYNSIVDMSEKLKENDKYNLVFDMEIDFVDLQFFNLILELIPKDSQYHTYYEETLKQQVTEYTNSLKTLMDSCISEKDQMIILEYEINYAKRKSIETETLGDKETKLSAVSQAYAKHLESYKGVLKPKLNDIKNNAFSVLKDSYCKDNCGEYVQKYNTMRKNFISSSDQYKMEAYVYIPKSINDYTVLDKILSESNELGIDIQETVNSLKLLGEEISEVSHLYVINSTLIDDAAKKLESINEEDESAEIDLQKFEDNSKALANNYCIFQYIKTLNEPIKKAYESKVIKSNELLSTIIDTLGKSATALQESTFDQEECNKIKTEAEKVKDDAEDICEKNEQIYYEIPESEDETIDDKINDLQDLIDQMKEYKDEIVNNSEFISNRYKNIYENLKETYETELNDIGKLENDTSKVNFYLMQIRKINTEKTKIDESLQTVEKFYKEILDSKEKIYELKIEFEKSVTEINRLQDGESARDLHEEQIKEILDKMAKKVHYLKELLSLKGKSSVYFTEMNELLNTASYDNMEGFSAKKEKADNDINALYNSVYREDINALIEEVEKFVTENKESTLEMLKDEEMEEKLQDAKETFAKLNFVSDDKLTDVYTKMSAEVTNAEGIKKEIAQKQFENVHKKMKEFSDAFSTKFEALQNSMQQYNQEGDAIEKHKQNRSEKEEEYFKNESVEEDLSREETEEQEYTKHKNNFSRRKGEISAEITNMREVINKIESQLNYYGVIEKYFSLIGDQNEVSTAKALKEKIVSDSLRDKIDQYETEFKEKTSAVENTVSTIQSLSKAIDSLKRLNGSINNCKKYNTDIDLLRSKIKTLREEVQKEIAETEGDKVVGENTTALLLKSLRDKMGKINEKLNDGRLNSLDTKKEDLLKFYSESKSKIHLSKDQKGPQDPLNRIDEWEDIKREVDELNVNYQVISENKVTLFKNNSVTYIEAMHSHINTVAHGITSNKNEILKSVKEVEDKLNLVEQNEDYKKVKNPENEKQLEAIRGSMSKLKEVINKHVSEMTQLESTANTLKSNAKGKENEHDLEELNKTKGQMRDIYEKLKKIAEELKEGTVNELKDANEKANKVELEFERNIIGHVLERITVEKDKAGKVVEEMNSLKTKIEKLIQETSDDSQNELVTTSITKHLENAKGYEDVIKRNEEDSIQLREKAKSLETLDEMKKLVQQVNMNLQSAIQGNAGISKELNELKGVIELLISTNYSSILEYVKKNSSESVRFSQLANGEFTKAEGEEKNASARLAEAEKLKEQIVKDLDYSDIDDKVKKIEGIKREILKMKESALTFWEESEKFKQMCSSHMENAKEGKKKIEYLKNNGDGGKANITDSQMEEVGNYVSKAEHAFHTVEAQVDKTKAFYESIVAYVTKMDNLFNESLMKEVKVKCEKKNDEAEQIFGQIKTVDGRIKARVSENERKISELKEKAKVEKKESSQLNDVSTKSLLQIDNCRQQLDSVLSNIGRVKQNALQYFDSADKSMKSVLPISELGAEKSLDKVKAAKESYEKNLETVQNEMSRINVEEGSLTDIDKKITDIENDLLKMKKQYEEGLLQKIKENADKRKSNFELVGSEINALLDPSTSIFIKLKLKEYDMTGDLKNYAVKMNEIHGEFTKSYNLIETHLSNATDYSVTFEKAQSLRELAEKEEEHLRRREEEAIKLLNDIKKVESLKLLKEMMKKVSAEYEGMKRDHTSVSQLVQDMKTIVDELKTLNDISECSSVLNNVVSIVKKVKESKHADYKRDANSMYESMVTLANYFLSDEAKISSGMEFNAEMKSNFKTDLELEIFSVISNSNELLKKIEQDSNDVIQKERESEQLAKDATDIYNVIKLKNEFNEKLEEAKNKEEVVSEKVREALKRLSQVEGIRCHFENFHRLLDNTEELENLKKMVTIYRDKKSEAPKESGLQEMENEMNTYSNSITQLEGIVVSAGESKEDIEKLERSNEEMRNISEKISTIDSKVIEMNSTIDELYKLGKNCQAHWISLISYTANMKTSKKLIMINKEKENTEKCVDYIKDNSSSTDGYVETLKGFYGSKLTFSSASEIVQNADTYSVNFAKHEKESLNAIRDIKKELYLFHQNSDISIVEGGVQNMLALYDKLNEEKREMDELYRNISETKLKQMEHSTDVFKPMIELHKGMNETNNKSLLEKEKKLKSVNDHMHSMEAEMIKNGLKYTPESVQNINNIYSVIEAEVKTLEEIDRDYGDNYQIVEEHKKQFSILIDRTNALMDDIEIFKKENNYNLMEVNTETIHRVNDYIEKITNKLVQAKTEYEQILENIKQNDDMLQNIFLKKVSIIEYFENVKKKKESILNDLYEQERLLKIGEHLDEIKRNVTETLSSYEIDQKMEMMSKNLLEKKSKMMNYTSIYELEREANEINRDAKQIKDDDTILNSVLEAAIQKRGDMDAIFSQMSADRNPNEYKSAEKYMNEANEIIRQLEVKLREIGQLVQDSESILSEMNSKKSAIEKEKTARALRTSENNRREEEERARVQEMSMNNDPTQSETTHSEGSIGEGKESDSDETGLTHDAGADEDSTSSAKGAHELEEEETTAPMEETEMNDNTLLGYDTTRSDEPDMHTENTQDGTYQDTSNSSDEADILNGKFNFNNVKYAGAFVLLCTSAVIGAIIAHKKDDQEELNNGVEDDKVFEVKKSMHPENKEEIIDDSFVDIEY
The following text describes a protein:
Function:
Catechol O-methyltransferase that can use various catechol-like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy-benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy-benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine.
Sequence:
MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVAYIQWAIRLARRGAVIVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR