lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTNDNWYIEHFQPTGSAIGYRISGKLDEVQSPFQKIEIYQTTDWGKLMIIDGAVMLTSRDNFFYHEMISHPALFTHAAPKRVVIIGGGDCGTLREVLKHPGVESATQCDIDEQVTRMSEKYFPELCDSNDDARAELLFDDGVAYMANCPAGSVDIVIVDSTDPVGPAEGLFNKSFYESCFKALKDDGILVQQSESPLALLDLIKEMRTEMGKAGFQSFKTLPFPQPCYPTGWWSVTMASKQANADFAFRQADAQAKGFDTLYYTAHLHTGVLVAPPFVAKALGE
The following text describes a protein:
Function:
May be an autophosphorylating tyrosine kinase, a bifunctional (serine/tyrosine-specific) protein kinase, or a serine kinase that is a substrate for an associated tyrosine kinase (By similarity). Acting in concert with putative serine/threonine-protein kinase gskl-2, required for sister chromatid segregation and spermatid budding during male meiosis. Plays a role in regulating female meiosis II, together with gskl-2. Involved in sperm pseudopod formation and function, together with gskl-2.
Subcellular Localization:
Cytoplasm. Cell projection, pseudopodium. Note=Expressed throughout the cytoplasm in inactive sperm from males. However, in activated sperm, becomes concentrated to the pseudopod.
Sequence:
MMNGFGIKNNGEFYSVSLQFGAHKLCGSGRFSNVYCGQMISPIEKEVAVKNVWSDTETRHLATSEYPEIQILSKLFHPAISNLLYFYSRNANDKVINCLVLDYLPQDLARLRDQGVKFDVLDAKLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETNEKTGSAYQVTRFYRPPELLFGCEKFTASIDIWSATCVAFELFANRVLFKGKDTKDQIVLITGVFGYPTDDDIKSIGVKRPRVARKDARGIETFTSKMLDSEIYDFMKATLKIDPKKRKSAIDVLKMPLFDILRSSPPKKRSNGVEMPNLASYTEMHHKREPETEVVADIQTTEKAEKESDSTNEELED
The following text describes a protein:
Function:
May be involved in transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MFGSVRLVQEVTRSNQQTAANTTSPASVDESIIAQEPSNVSDLTSEPVESTQIKQQGNTEASQDIQQEQQQQQTHIHPQQPALSAQQTQQQPALPCWSTPTQHIPISFSAITSPSVLSSYKSRDFRNLFTTTNSSPNPSSPSPSSMKSHTRKNSKYTVRHHRTRQSSFNGTTNPPAYFSSNSILRKQPPTHHPQRNFLQLQQEQQKSKSQKLLCLWPLPTVTRYMILIALFVSTLNCLHILDLSCSAPSFVVYRFDIKNMILSPFLFNWTLPSMALFGWNVLILGLFEESLAHMVGGTRRFIQLLLVLFTTVSLVRVCLGLIFSKATGYAFPSLFFSNTMHECSQGLCVCCIF
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.
Subcellular Localization:
Nucleus.
Sequence:
MQKARNAREEADDDAFRSSRKRKVQWADVNAENKELAIPSPSRLATYADDAVHSNSRVDEHGMLVSIDRDSDQPVSLDPSNAAQKQYLASEIYNPIEYGDFGSYMKHKRAKLKVQEASLLQEEEALLRVRVPQATTTDKQGHHLAAEIQSNAGKRSDALKGCCVYINGQTHPPYSELRRLLVLHGGDLMAYLDQKTPVTHIVASNLTPKKRIEFKDYKVVLPGWILESIELGRKADWRKWRCDANTGSNGHTSKSIICKNDGDPSTSIVPLGDWRNSDRTAKPPRQLPRIGEEDESPWGKPTNQTNLLNGFKRKQGSPTAKDLPTFFTEQSIPAPLPKPKSESSQTRRETTFKGVRFGAKQIIQPATSILSSEPTSTSSSVHLASSAATESVNVRRLHETRSHPTTKEARAPEDSIVTPTKPKGKFDSSIGTDPASKKAAIAVSRGHYASRPSNTYAARLLASPSWRERNTATSEGFLAGYFAKSRLHHLSTWKSSLQDMVSSALREAGRPLGSSDLPKGVQRVIMHIDFDSFFVAVGLKKRPDLKDKPVVVCHGTGFGLPAAKAGDENRPADNQSSSTSEIASCSYKAREFGIRNGMSLGQAKRLCSHVETIPYDFEAYNSVSLTFYTFLLEHSDALQAVSVDEALVDVSLLLQSMRDGDTNDGSLYQRYRDHLGSQGQVWTAEKQLAEAFRDEIRDRCECEASIGIGSNILLARLATRKAKPGGSFHLTDDAKQLFLNALDVDDLHGIGWSLRDRIRELFQTINIGEILSKTNKRRMMAEFGPKKGKMIWDRMHGIDADRLEGNKLRQSVGSHVNYGIRFLTEQEAENFVTGMCQEVSQRAKAVKLRGRQVSVQVMVRAKTAPVEAPKFLGHGVCDTHHRSAPVSGPGGVAIDDEARIRAAAWPLIRDLKADPKELRGIAISLNKLEPADANVLSPAKSTGGQAMLRFGSVAQSSSSKLVLAASKRSARDAEEASNASDVEQLDEPGIELPASLEKGPDAATPRRPQDTDKCKRTSNRPSPSEGSPIKMPSATQLMLPSKSQIDPDVFDALPTQYRRQIEAKLGPPRGNSLTDNFEADLVEEESPDTTRRLPQSRTGSQTLPRVLPRSTPTTPQKAKVTPSPAMAEALMLPSASQIDPVVLAELPDSVRKEIERQLGFLHHEVPSAPSSVESTPTSKTRKKVANTSTLLHFLQRDTSKVTDRHNSLFRSISESPTKERVVHRLDRDALLVMDPAKISLSQLEAVGIDAEVFQALPMDLQRETFQFHSEQKKSEKARFKAGKSSGFEELTLAEQRRRETVRAALKEKEARTRVEERLRGNRTASKGTYAVALAAEGQGDVASDPPAYLIARPKWRVPSEASVILNTANAEKSSRDIPTIRGLSHPRDVEILLSQWISAFARKGPREGDVNRIATYLADVVRTASVTRVEDTQKASSLLGFIQERLDEVQYKIDDGFASEEWETAKRKIRDAVQAKSREVFGGAELEE
The following text describes a protein:
Function:
Acts as a positive regulator of apoptosis. May also act as a regulator of cellular reactive oxygen species.
Subcellular Localization:
Nucleus.
Sequence:
MIPLEKPGSGGSPSAAASGSGPGGLLTEIRTAIRTEPFQDCYSLSPGRELGRGKFAVVRKCIQKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETSSEMILVLEYAAGGEISDQCVADRDEAFNEKDVQRLMRQILEGVHFLHTHDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRIVKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGDNKQETFLNISQMNLSYSEEEFDTVSESAVDFIKKLLVKKPEDRATAEECLKHPWLTQSSIQDPVLRVKEALEEANALQKGDSVPEISSATEKPGTEESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MASPNPAQSTTILFRRLTWQSAVTISIRLADGEPGAGNACDRYYIKAPRYSYLPLFIPEIRENLVELALDDAQLEQIDEKNWWFEEEVSEEDKQRFVRQGACRWHWPIDLVDIHSFISRPQPLPSSIELSSTPRVISLLLHLSNPPQDRLLMPNSIEVCKSQWLNQVKEADFVRWRNTNRVTNLRRVDLEAGWDGIVNNDFDLYAQMVNKIVPLPLLTSSNSTQPSRPSSADPSGPPRAPDSSYATRAIPFKIYLPDNAPVIQEIVPPISESGKPTTLLAVLQVHLPLLFPISSENPYELAFPIAQGILIPQEAEVAWIASCLCGVDGWVRVGVCLSAA
The following text describes a protein:
Function:
As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (Probable). In particular, may act redundantly with the intraflagellar transport protein ift-139 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MIILENEANEPGFRIQQRAESETGKKGRFGGILKENPIKGFSSETLTRPLTGLFRKTGKSQRKTDDDDSQETIAAPPTNFPNMARISATIESVQINDEYAGYRDRNPETGSKLTLNEGAGVFGNAMHPLTRYFKVGDVDVSILGRSFPTEKTVDEEGPWTAQSLFNSLESRIKKERIDAKDQPSDSRSRNARETLISSKY
The following text describes a protein:
Function:
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.
Sequence:
MDYYCSEVVHGIRVTGACTSNFVVQIEGTPQSDIELPVNSPVQLWKLKHRDYIVNYGKSKDDYEYCMSEYLRINGVYWGITALCLLDQLDQLNKTEVIDFVKSCQHPSSGFGASPNHDPHILSTLSAIQILTIYDAVDEIDVDGAVNFIHCQQQNDGSFSGDKWGEIDNRFSFCALACLSLLGRLDAINVDSAIDFILKCMNFDGAFGCKPGSESHSAQVYCCVGSLAITGRLHHLNIDALGWWLSERQLPSGGLNGRPEKLPDVCYSWWVLSSLAIIGKLHWINKVKAILSRDNIFRHCPENLLLNHILLTKINDILQLLFFFLIVKEKLINFILACQDKETGGIADKPGDLVDPFHTLFGIAGLSLLGDTTLKQVNPVYCMPEEVIQKLRLKVQMLN
The following text describes a protein:
Function:
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction; [Isoform 5]: Does not bind IL15; [Isoform 6]: Does not bind IL15; [Isoform 7]: Does not bind IL15; [Isoform 8]: Does not bind IL15.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Cell surface. Note=Mainly found associated with the nuclear membrane; [Isoform 5]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane; [Isoform 6]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane; [Isoform 7]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane; [Isoform 8]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane; [Soluble interleukin-15 receptor subunit alpha]: Secreted, extracellular space.
Sequence:
MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL
The following text describes a protein:
Function:
Catalyzes C-C bond formation between the carbons ortho to the phenolic hydroxyl of cyclo(L-tyr-L-tyr) (cYY) producing mycocyclosin. Can also use cyclo(L-Tyr-L-Phe) (cYF), cyclo(L-Tyr-L-Trp) (cYW) and cyclo(L-Tyr-L-3,4-dihydroxyphenylalanine) (cY-DOPA) as substrate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW
The following text describes a protein:
Function:
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRVRVGLTLLLCAVLLGSASASSDEEGSQDESLDSKTPLPSDESVKDHSTAGRVVAGQIFLDSEESELESPIQEEEDSLRSQEGESVTEEISFLESPNSENKDYEEPTKVRKQALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAAGMNHTKALERVSYALLFGDYLTQNIQAAKEMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQRHREAEREKESPCREPNARLNPRNLGSHPEQKADTQPLSYQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNLHERSEVLCCHQNRTLQLVCCQNRQIRDMFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPLPRPPGPRPGPPQQEGPPEQQPPQ
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MATPYQPLFRETPKQNPIISCKILTFVITFVVALFSVVFLVAPYQFELEHSKISSLPAPQLCESAQDSQLCLSYVSELVSNGIVTSDSHGVAVLQKFLVKYVHHMNSAIPVVHKIRNQINDISQKGALADCLELLDLSIDLVTDSIAALGKTRSHLAHANAQVWLSGVLTNHVTCLDGLDSLSNTASTGTILEELISRAKTALAILASVTTDPNEEVFRPLLGKIPWVSSSDRKLLESSAKDIKANAVVAQDGSGDYQTLTEAVAAAPDKSKNRYVIYVKKGTYKENVEVTKKKMNLMIVGDGMNSTIITGSLNVVDGSTTFRSATLGKSSVYQTTYSFFLIWSN
The following text describes a protein:
Function:
Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting aspartate and glutamate. Requires ATP for function.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MVASIRSGVLTLLHTACGAGILAMPYAFKPFGLIPGVIMIVLCGACAMQSLFIQARVAKYVPQGRASFSALTRLINPNLGIVFDLAIAIKCFGVGVSYMIVVGDLMPQIMSVWTRNAWLLNRNVQISLIMLFFVAPLSFLKKLNSLRYASMVAISSVAYLCVLVLLHYVAPSDEILRLKGRISYLLPPQSHDLNVLNTLPIFVFAYTCHHNMFSIINEQRSSRFEHVMKIPLIAISLALILYIAIGCAGYLTFGDNIIGNIIMLYPQAVSSTIGRIAIVLLVMLAFPLQCHPARASIHQILQHFAEENVSISATSADEPTVATESSPLIRDSSLDLNEVIEEESIYQPKETPLRGKSFIVITCSILVASYLVAISVSSLARVLAIVGATGSTSISFILPGLFGYKLIGTEHKTAVPLTTKIFKYTGLLLFIWGLIIMITCLTAALKLN
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MAVMDSSSTAVLLLLLASAGIASAALTWDRQFLDPHNAARNAVKVPNLSWDWNLAKYAQNWANNQARDNCKLKHSMGPYGENIYWASWSSTPLDAVKAFVDEKPFYNYASNTCKAGEMCGHYTQVVWKTTTKVGCASSKCPGGGTYTVCSYNPPGNYIGMRPY
The following text describes a protein:
Function:
Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex.
Miscellaneous:
MISCELLANEOUS: Present with 1400 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGKRVYDPIHDTFQLREDNSDETKADSPMQSVKSGSQEEASPSSIQSETETVTTKSIPVIHEIEIDDKNDDDSTQSEEENTNILLNFEPSTVPEATGASTATGPVTTNTVRRKPKESNASKYNRHLKKPDGEPFNRKDIQFSFMQELLMDKRQIFTNVLKPLYKNSIVPINIDGDKLSINVTDKEYDARTFVFNDKLTFAQLYVLTIATSIKCSKILRDKLLLDQQVAFSTCVLALLVNIGRLNTTINFYLEMTSQLRTFHSVPVLQLHANDPKLLQDTPRLKSILKNLPWGNEQLSLMETYKKVDQNDGEVDTVNKFNIINMLFSICDNSGLIDKRFLSKYVEVESKAQEQDMVDEQNEVKETEAENEKQESKAAYATTLFDILDYSKYEPKDRSNILIWLLYIHLETNLSQEEVEESVRFFNGLEDGAPAGKFILRCTERSYDTDPEDELEFGANQRIKRREFMSKMEEGRKRERTNVTEVKKPSIGGDKSEEDGEGEDDKSEETVEETRSLLTPTPILESSSPMTLNRKKVTPQLPKVTPAAPTETEEEITSAAIIDKNDLNLTPLKKYNSSATVNKVDKLISLDLNKHVSENGKTQEEFLADLKKSQVPNRLKRRDIGLIKIFNEFEDIPVASVLGIRGKKRKKFKDNLLGFETDFMKNLGASKKVLLNKIERAEIDDEEATAMFKLE
The following text describes a protein:
Function:
Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLVRLIGAEARHLAKRSYSSAAPTTKLFIDGKFVESKTNEWIDVHDPATNQVVTRVPKATQAEMQAALESNKKAFRSWSNQSILTRQQVMFKLQALIKENMGELAKNITKEQGKTLADAEGDVLRGLQVVEHCCSIPSLQMGETVANVARDMDTYSLVLPLGVTAGVAPFNFPAMIPLWMFPVAITTGNTMLLKPSERVPGATMLLMELLNEAGCPPGVVNVIHGQHDAVNFICDAPEIKAVSFVGSDQAGKYIYERAGKNGKRVQSNMGAKNHGIILGDANKENTLNQLAGAAFGAAGQRCMALSTAVFVGDAQAWIPDLVERAQKLKVNAGHVPGTDVGPVISAASRQRINDLIESGVKEGAKLILDGRKITVPGYEDGYFVGPTILSDVTPSMKCYTEEIFGPVLVILKADTLDDAIGIVNANPYGNGTAVFTTNGAAARKFVNEIDAGQVGVNVPIPVPLPMFSFTGTRGSFRGDHHFYGKQGIKFYTQTKTVTQLWRKTDVTHTQAAVAMPTMK
The following text describes a protein:
Function:
Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly.
Miscellaneous:
MISCELLANEOUS: Present with 521 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSHPIQFVNANNSDKSHQLGGQYSIPQDLRENLQKEAARIGENEKDVLQEKMETRTVQNREDSYHKRRFDMKFEPDSDTQTVTSSENTQDAVVPRKRKSRWDVKGYEPPDESSTAVKENSDSALVNVEGIHDLMFFKPSDHKYFADVISKKPIDELNKDEKKERTLSMLLLKIKNGNTASRRTSMRILTDKAVTFGPEMIFNRLLPILLDRSLEDQERHLMIKTIDRVLYQLGDLTKPYVHKILVVAAPLLIDEDPMVRSTGQEIITNLSTVAGLKTILTVMRPDIENEDEYVRNVTSRAAAVVAKALGVNQLLPFINAACHSRKSWKARHTGIKIVQQIGILLGIGVLNHLTGLMSCIKDCLMDDHVPVRIVTAHTLSTLAENSYPYGIEVFNVVLEPLWKGIRSHRGKVLSSFLKAVGSMIPLMDPEYAGYYTTEAMRIIRREFDSPDDEMKKTILLVLQKCSAVESITPKFLREEIAPEFFQKFWVRRVALDRPLNKVVTYTTVTLAKKLGCSYTIDKLLTPLRDEAEPFRTMAVHAVTRTVNLLGTADLDERLETRLIDALLIAFQEQTNSDSIIFKGFGAVTVSLDIRMKPFLAPIVSTILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNIILYESLGEVYPEVLGSIINAMYCITSVMDLDKLQPPINQILPTLTPILRNKHRKVEVNTIKFVGLIGKLAPTYAPPKEWMRICFELLELLKSTNKEIRRSANATFGFIAEAIGPHDVLVALLNNLKVQERQLRVCTAVAIGIVAKVCGPYNVLPVIMNEYTTPETNVQNGVLKAMSFMFEYIGNMSKDYIYFITPLLEDALTDRDLVHRQTASNVITHLALNCSGTGHEDAFIHLMNLLIPNIFETSPHAIMRILEGLEALSQALGPGLFMNYIWAGLFHPAKNVRKAFWRVYNNMYVMYQDAMVPFYPVTPDNNEEYIEELDLVL
The following text describes a protein:
Function:
Subunit of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I. Binding to the DNA template is dependent on the initial binding of other factors.
Subcellular Localization:
Nucleus.
Sequence:
MFSPCTVKEKRSTLRSVAPNPESSVIPPIPLPSRRYKTRHIDALCSLMHLCLLRKDYPRASRAFSLLLRSKSVDISKLWNIGLEILNKVNPEASSEYMERLIARYPARPSINNSYPNRNAEHFFPAYIMLLIQRQEYNKAMKLLDEYLLLPPYNQNPALHEYSGMLCFELAKEEASESERTKWIEKAKYNFSNAGIDVEL
The following text describes a protein:
Function:
Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mainly localizes to primary cilium and is removed from primary cilia in presence of shh.
Sequence:
MNGSKNGTAVANSTNGLDDNGLMVLESVSIIIIAILACLGNLVIVVTLYKKPYLLTPSNKFVFSLTSSNLLLSVLMLPFVVASSVRRDWMFGVVWCNFTALLHLLVSSSSMLTLGAIAIDRYYAVLYPMIYPMKITGNRAVLAIVYIWLHSLVGCLPPLFGWSSFEFDRFKWTCTVSWHKEISYTAFWVTWCCLLPLVAMLVCYGVIFRVARIKARKVYCGSVVVSQEESSSQNNGRKNSNTSTSSSGSRKSLIYSGSQCKAFITILVVLGTFLTTWGPYVVVISTEALLGKNSVSPQVETLVSWLSFTSAVCHPLIYGLWNKTVRKELLGMCFDDRYYRESFVIRHRTSRLFSISNRITDLGMSPHLTAMLVGGGQLLGRGSSTGDTGFSYTQDSATDVMLLESYTSEASHSAHCTANKRRSSVTFEDQVDHIPQGDPSVVQVTADIHKSLDSFASSLAKAIENDAKLQLLGEWTQIPTSLFTVRNTQRVPRYLDGQRLRMESIDEGIVKDDDDDEEEMEREEKM
The following text describes a protein:
Function:
No E3 ubiquitin-protein ligase activity observed when associated with the E2 enzyme UBC8 in vitro.
Sequence:
MGQQQSKGELLYQQVSYGNSEGIRALHRDGGDLEWMDREGKTPLILACMNSELFDVAKTLIELGSNVNAYRPGRHAGTPLHHAAKRGLENTVKLLLSHGANPLVLNDDCQTPLEVARVKGFSNVVRAIEKHICLFSGWMREFYGPTFLDLFAPQLLSRRVWVVIVPTGSRNPTKPFKLELVVYASLQDAQPRTVMPLWKANLEEPKAKQSDTSVMIVDNSTIPSRRMKKRRVCASHGRRRPQVVRQTRLKFAPSTEGDSQQLKWFCDACKGIPQPMHPPVFLQAPPSAPPPPSEDGLAMGMNASLHTTMSDPSNLNHHSIGQASSSSGPSSSTAPPSGKASAFGFNSHGIGIVLESSPSAPPLTDDDIATVDDGPIHYPSIDSTPVDLPSAASLPASTEGERKEDGNTGTCAICLDAPSEAVCVPCGHVAGCMSCLKEIKSKNWGCPVCRAKIDQVIKLYRV
The following text describes a protein:
Function:
Required for ESX-1 function. Required for either stability or expression of EspA.
Subcellular Localization:
Secreted. Note=Secreted via the ESX-1 / type VII secretion system (T7SS).
Domain:
The C-terminal region is required for secretion by the ESX-1 system.
Sequence:
MTENLTVQPERLGVLASHHDNAAVDASSGVEAAAGLGESVAITHGPYCSQFNDTLNVYLTAHNALGSSLHTAGVDLAKSLRIAAKIYSEADEAWRKAIDGLFT
The following text describes a protein:
Function:
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
IFYLFKIVFCSKPDTCFSISFHSFPKDMSVRAEWIVRVRREDFTPSKTSRVCSRHFQKGDFVNNPGKLRKLKKGAIPTLFSWNDFQIPAPRCTSNIKSKVIYD
The following text describes a protein:
Function:
Transcription termination factor involved in the regulation of mitochondrial-encoded gene expression. Essential for normal plant growth and development.
Subcellular Localization:
Mitochondrion.
Sequence:
MFMVRLKFASISHNFSTVAAKHRRVPSKYKSLAIGKAQQAITDYLHTTRSLSYTHAEQIASNASVSIRNLILKLDFSVPTFSKSLRKHLSYHPINEFEFFFESIGIDYSEVSEFLPEKKFFFSEDRTVLDAAFALSGFGFPWNKLGKLYKEERLVFVQRPGEIESRLLKFKDIGFSTVAVIGTCLAIPRTLCGGGELGSEIRCLFVKLKRLFDEFDSHHLFEENVDSWLAVSRKIRIFYDLGCENEEMWELMCRNKSLFLEYSEEALMNKAGYFCRFGVSKEDAALLILRNPAIMNFDLEKPVISVTGMLKHFGLRQDEVDAVAQKYPYVFGRNQLKNLPYVLRAIDLHERIFDILKNGNHHLLASYTLMDPDEDLEREYQEGLEELQNSRTKRHNIQKLDFLHEIGFGENGITMKVLQHVHGTAVELHDRFQILLNSGIIFSKICMLIRSAPKILNQKPHSIQDKLRFLCGEMGDSLDYLEVFPAYLCFDLENRISPRFRFHKWLVEKGFSEKSYSIASIVATSEKAFIARLYGIHPAIPKHWFERFSSRKTRDTVS
The following text describes a protein:
Function:
Regulator of neurite outgrowth required for normal hearing and vision.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKLWTYLLYPSLLACLSLQSQSPMPSVRGSCDTLCNCEEKDGIMIINCEEKGINKLSQISVPPSRPFHLSLLNNGLTMLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITIIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCELLQLKNWLENMPPQSIIGDVICYSPPPFKGSVLSRLKKESFCPTPPVYEEHEDPSGSLLAITSSTSDSRLSSKNTSILKQPTKAPGLIPYLTKPSTQLPVPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLQPPPHNPRKLILAGNIIHTLMKSDLTDYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSNILDDLDFLIQIDLEDNPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCPGLVNNPSMPTQTTYVIVTSPTVAADTASTLFSSLTDAVPLSVLILGLLIVFITIVFCAAGIVVFVLHRRRRYKKKKVEEQLRDNSPVHLQYSMYGHKTTHHTTERPSSSLYEQHMVSPMVHVYRSPSFGPKHLEEVEERNDKEGNDAKHLQRSLLERENHSPLTGSNMKYKTTDQSTDFISFQDASLLYRNILEKERELQQLGITEYLRKNLAQLQPEVEVNYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQT
The following text describes a protein:
Function:
Involved in brain development probably by regulating asymmetric division of neuroblasts. Regulates neuroblast asymmetric cell division by controlling asymmetric protein localization of Mira, Baz, Par-6 and aPKC, and spindle alignment. Also, regulates the localization of kinase Ball during mitosis, specifically maintaining Ball in the nucleus during interphase. Required for proper ER and nuclear envelope morphology in neuroblasts.
Subcellular Localization:
Endoplasmic reticulum. Nucleus envelope. Cytoplasm. Note=In neuroblasts, recruited to the nuclear envelope at the initiation of mitosis and remains associated with it until the beginning of cytokinesis.
Sequence:
MSTYFGVYIPTSKAGCFEGSVSQCIGSIAAVNIKPSNPASGSASVASGSPSGSAASVQTGNADDGSAATKYEDPDYPPDSPLWLIFTEKSKALDILRHYKEARLREFPNLEQAESYVQFGFESIEALKRFCKAKPESKPIPIISGSGYKSSPTSTDNSCSSSPTGNGSGFIIPLGSNSSMSNLLLSDSPTSSPSSSSNVIANGRQQQMQQQQQQQPQQPDVSGEGPPFRAPTKQELVEFRKQIEGGHIDRVKRIIWENPRFLISSGDTPTSLKEGCRYNAMHICAQVNKARIAQLLLKTISDREFTQLYVGKKGSGKMCAALNISLLDYYLNMPDKGRGETPLHFAAKNGHVAMVEVLVSYPECKSLRNHEGKEPKEIICLRNANATHVTIKKLELLLYDPHFVPVLRSQSNTLPPKVGQPFSPKDPPNLQHKADDYEGLSVDLAISALAGPMSREKAMNFYRRWKTPPRVSNNVMSPLAGSPFSSPVKVTPSKSIFDRSAGNSSPVHSGRRVLFSPLAEATSSPKPTKNVPNGTNECEHNNNNVKPVYPLEFPATPIRKMKPDLFMAYRNNNSFDSPSLADDSQILDMSLSRSLNASLNDSFRERHIKNTDIEKGLEVVGRQLARQEQLEWREYWDFLDSFLDIGTTEGLARLEAYFLEKTEQQADKSETVWNFAHLHQYFDSMAGEQQQQLRKDKNEAAGATSPSAGVMTPYTCVEKSLQVFAKRITKTLINKIGNMVSINDTLLCELKRLKSLIVSFKDDARFISVDFSKVHSRIAHLVASYVTHSQEVSVAMRLQLLQMLRSLRQLLADERGREQHLGCVCASLLLMLEQAPTSAVHLPDTLKTEELCCAAWETEQCCACLWDANLSRKTSRRKRTKSLRAAAVVQSQGQLQDTSGSTGSSALHASLGVGSTSLGASRVVASASKDAWRRQQSDDEDYDSDEQVIFFDCTNVTLPYGSSSEDEENFRTPPQSLSPGISMDLEPRYELFIFGNEPTKRDLDVLNALSNVDIDKETLPHVYAWKTAMESYSCAEMNLFPSPRNVKVQKPEPWYSGTSSSHNSQPLLHPKRLLATPKLNAVVSGRRGSGPLTAPVTPRLARTPSAASIQVASETNGESVGTAVTPASPILSFAALTAATQSFQTPLNKVRGLFSQYRDQRSYNEGDTPLGNRN