lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries. May be involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSRRGSLNQGSTDVIDKSAKLDTRSRPHLTRFSSMESFKQVETRSSKQKKKFEFNSSRVSPIPSSTSQLGALNSSKSSNQIFASSKKFFSASVPGSRIVSRATSPTSIRPSPPRSTTPTPTLGGLTSPRIVVDDAKRTNESLSQEITKLRAQYLKKMAETLPVGPGRNIKSPKSVSSESSITSSDIPNGCIDQVHSQLTFQELESSVSNSQLLSNGSSNASNRSAIHNRQGYPEATTKNGARTKECDSRNENEWVEQDDPGVYITLTSLSGGVKDLKRVRFSRKRFSEKQAEKWWEENRASVYELYNGGIKGWHRRTRNYMFACKRAVNLVSEQFRTLASLRNYLAPPLAAALPPRLFSAGALRLMFHLDISYSFPIKFQPMLPTQQAQPYGSGSSQQFLPLGHANVAMSQPFQIQFPQPVQQVTSRPVVGMHSMPQGPPIPHDFQRNLPMSNNHMPGSGGPNLPLSSSYNQVNADSSGSQYQTQINDHRFPLGVVPLDANKLKVTGSLFFGFQEANYVVDPVETIQSDWIEHTSRKGKKNKSMPIWLSGILAFGLYSHRLLSSSEPASLAVANSEKIGIAVTLENSVAPPVSETTTAQDAVVYGNEFSSENRENAKKDAAITEIGGATPSYEKTVELGPLVYESKAEAKSTFKTLLESANIGSDCTGDQAMRAVINDRRYGALKSLCERKQAFNEDYKELSPSSRWSKAISIFEHDERFKAVERAKDREDFFEDYVEELEKKVKLLLQNFLEHAKALEEQKRNRVEYLEFLKSCDFIKEYIRDLESEEEEQRKLRMVYCLLDSGVKIKFMFGDFDLSLRKNRDKFRKLMEEHVAAGILNAKTNWRDYCIKIKDFAAYLAVSSNTSGSTAKDLFTDVMDDLEKQMLWMSWRNR
The following text describes a protein:
Function:
Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via outer-ring deiodination (ORD). Catalyzes the deiodination of 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via ORD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRUILD
The following text describes a protein:
Function:
Thiol-disulfide oxidoreductase catalyzing disulfide bond formation of chloroplast proteins and involved in redox regulation and photosynthetic electron transport. Required for the assembly of photosystem II (PSII) through the formation of disulfide bond in PSBO, a subunit of the PSII oxygen-evolving complex in the thylakoid lumen. Involved in the formation of disulfide bonds in the lumenal protein FKBP13. In vitro, reduces phylloquinone (vitamin K1) and menaquinone (vitamin K2) to their respective quinol. Cannot reduce phylloquinone epoxide to phylloquinone. Plays an important role in regulating the thylakoid lumen redox.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Domain:
Cysteine residues from the thioredoxin-like domain participate in a series of disulfide-exchange reactions that regenerate the redox-active cysteine residues in the transmembrane domain.
Sequence:
MMARFVSVSSCQFHFGFREVSPPSVTSYPRRFEVSDRRFPAIPIKCSSSEPENGEDSAPSLSSSSSSSTSEVSTSNSSTYNWYTGIGGIGMLDTAYLTYLKVTGSDAFCPIGGGTCGDVLNSDYAVVFGVPLPVIGFVMYGVVTALSAELGEGNLPFGISKSNGRFALFGITTAMASASAYFLYILSTKLSGSSCLYCLVSAFLSFSLFFLSVKDVKLQEIQQVVGLQICLAIIVVASLTASYSTAQPIPSRSGDIELPYFRTEISSSSSPYAIALAKHLNSIGAKMYGAFWCSHCLEQKEMFGREAAKELNYVECFPDGYKKGTKILKACADAAIEGFPTWIINDKVLSGEIELAELAEMTGFSLDQANETNQLQ
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MKIGNLPQKAGLLGAMRVVRWVGVVGLEIHAQINSESKLFSSSRVQFAAPPNSTVSFFDASLPGTLPVINRRCIEAAVMTGLALNCSINKKSLFDRKHYFYADLPAGYQITQQRLPVAVNGTLTYRHQVGAKWNQMLTKCVRIKQVQLEQDSGKSLHDEIRRQTLVDLNRAGVGLMEIVMEPDMSCGEEAAAAVRELQLILQALGTCNANMSEGQMRVDANISVHRPGEPYGVRTEVKNINSARFLAKAIDYEIQRQVDVLENGGTNLNETRAFDYKLGATIPMRDKEGKQDYRFMPEPNLPPLVLYDSNSLPANADPDQIINIDLIRKNQPELPSVIRERLVEQYGILPEQSFILVNEEGLQEYFQTVVRMTNVDPKKIIGWLINDLLGHLRQQNLTIKQSPVSPVALAELLTLLDNGSISSSAAKQVFQELCKGGEKTPAEIIKEKNLGLLKDRMQLEEICQRILNGHQKEVAEIRQGNHKIMNKLIGLVQKATKGRADPVLVKSILEEKVLS
The following text describes a protein:
Function:
Component of the terephthalate 1,2-dioxygenase multicomponent enzyme system which catalyzes the dioxygenation of terephthalate (TER/TPA) to 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylic acid (DCD). TphA1 probably reduces TphA2A3. It can also use 2,5-dicarboxypyridine (PDC) and 1,4-napthalenedicarboxylic acid (NDC) as substrates, and preferentially uses NADPH which is the physiological electron donor.
Sequence:
MNHQIHIHDSDIAFPCAPGQSVLDAALQAGIELPYSCRKGSCGNCASTLLDGNIASFNGMAVRNELCASEQVLLCGCTAASDIRIHPSSFRRLDPEARKRFTAKVYSNTLAAPDVSLLRLRLPVGKRAKFEAGQYLLIHLDDGESRSYSMANPPHESDGITLHVRHVPGGRFSTIVQQLKSGDTLDIELPFGSIALKPDDARPLICVAGGTGFAPIKSVLDDLAKRKVQRDITLIWGARNPSGLYLPSAIDKWRKVWPQFRYIAAITDLGDMPADAHAGRVDDALRTHFGNLHDHVVHCCGSPALVQSVRTAASDMGLLAQDFHADVFATGPTGHH
The following text describes a protein:
Function:
Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 184 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Vacuole membrane; Peripheral membrane protein.
Sequence:
MGLIKKVTHWSYDNLIDYLSVNPTRDEVTHYKVDPENESDESIIKLHTVKDFGSITCLDYSESEIGMIGVGEKNGYLRIFNISGQNSSSPASHAPVGLNANNETSMTNASGGKAAQAENIVGSVSNLKDTQGYPVSETNYDIRVRAKKQRCINSLGINTNGLIAMGLDRNKHDSSLQIWDMNYHDDSHETINPMFSYCTNESIVSLKFLNDTSVLAASTKFLKEIDVRSPNPIYQHPTRLTYDIKLNPFNDWQFSTYGDDGTLAIWDRRKLSDQASLGDLNVASPLLTFEKLVGSGAASRKYMNSCFRWSCVRNNEFATLHRGDTIKRWRLGYYCDSNRDIAADDDNEMNIENLFVSSVHDTNTMYDRVATFDYIPRSNNGTSLICMRQSGTIYRMPISEVCSKAILNNRNSLLLSNFENTEIDEIRVNNEHEKSNLENVKTILKNLSFEDLDVSEDYFPSGHDEPNNEIEYSELSEEENEGSNDVLDSKRGFELFWKPEKLLEKDISVIMRTRASLGYGLDPMNTVEMIDSSKNLQNNAYIRNTWRWIAIAKASVDDGTMVSGDLDLGYEGVIGIWNGINGISNQDRYRQETILSDKQLNKEMEKIIKLRRKNRDRNSPIANAAGSPKYVQRRLCLIISGWDLSRSDYEDKYNIIMKNGHYEKAAAWAVFFGDIPKAVEILGSAKKERLRLIATAIAGYLAYKDLPGNNAWRQQCRKMSSELDDPYLRVIFAFIADNDWWDILYEPAISLRERLGVALRFLNDTDLTTFLDRTSSTVIENGELEGLILTGITPNGIDLLQSYVNKTSDVQSAALISIFGSPRYFRDQRVDEWIQTYRDMLKSWELFSMRARFDVLRSKLSRTKTGVLTADIKPRQIYIQCQNCKQNINTPRTSSPSSAVSTSAGNYKNGEAYRRNNADYKKFNTGSSEAQAADEKPRHKYCCPHCGSSFPRCAICLMPLGTSNLPFVINGTQSRDPMQTEDSQDGANRELVSRKLKLNEWFSFCLSCNHGMHAGHAEEWFDRHNVCPTPGCTCQCNK
The following text describes a protein:
Function:
MSBP1 can bind to multiple steroid compounds with different affinities. Negatively regulates cell elongation and brassinosteroid signaling. May act as a coreceptor with BAK1 and enhances its endocytosis.
Miscellaneous:
MISCELLANEOUS: Regulated by both phytochromes and cryptochromes.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Domain:
The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 109 and 133.
Sequence:
MALELWQTLKEAIHAYTGLSPVVFFTALALAFAIYQVISGWFASPFDDVNRHQRARSLAQEEEPPIPQPVQVGEITEEELKQYDGSDPQKPLLMAIKHQIYDVTQSRMFYGPGGPYALFAGKDASRALAKMSFEEKDLTWDVSGLGPFELDALQDWEYKFMSKYAKVGTVKVAGSEPETASVSEPTENVEQDAHVTTTPGKTVVDKSDDAPAETVLKKEE
The following text describes a protein:
Function:
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Subcellular Localization:
Secreted.
Sequence:
MSVLEENPGMKMDCEDWERDEPQCSSEDSVRDALEPGPSLTSMSAAHAGPRVKANGPEKFTIHDGDQKVLVLDSKTLRAVPDKTYILPEIFFVLASRVKSAYENKGSPIFLAVSKGQLCLCCDTNKGHKPSLQLKKKKLSKLAAQKKGKYLPFIFYRNKVGSRNTLESAAHPGWFVCTFPNPGKPVGMTKSHGRRKHTEFSFRRI
The following text describes a protein:
Function:
[Isoform 1]: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; [Isoform 2]: In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons.
Subcellular Localization:
[Isoform 1]: Secreted; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.
Sequence:
MRAVPLHLVGTASLTLGFLLLLSLRLDPGQAKELKFVTLVFRHGDRGPIETFPNDPIKESSWPQGFGQLTKWGMGQHYELGSYIRRRYGRFLNNSYKHDQVYIRSTDVDRTLMSAMTNLAALFPPEGISIWNPRLLWQPIPVHTVSLSEDRLLYLPFRDCPRFQELKSETLKSEEFLKRLQPYKSFIDTLPSLSGFEDQDLFEIWSRLYDPLYCESVHNFTLPTWATEDAMTKLKELSELSLLSLYGIHKQKEKSRLQGGVLVNEILKNMKLATQPQKARKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHIMELYQDNGGHFVEMYYRNETQNEPYPLTLPGCTHSCPLEKFAELLDPVIPQDWATECMGTSNHQASL
The following text describes a protein:
Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular Localization:
Cytoplasm.
Sequence:
MSESAKAAAQNGQAEEQQLQQQLDEQQQLEEQQQLPPVTIRIPSPTCSRTVPKPKDSTEPLDRITLYPQPQETIQDIKLLINDWVGAYWLGPYSLQLPFVKGEDGRGKIYSKKKDFSEVRAGEKLNEWLEVQDAFEHLQEGEERVLEAVREPYGELSARQSIIRLLELIAPSGTTANTTSNPLGLQAGSTIFEQVRDGLVSANAETTYEEVEVSLPSGRKGKGGKKELVKVKRSVSGDKAHAFADWKGWAPASFGSLAVSSDPVEVAPSLKSIQISHFNPPPPHLRQKGHELYLQVSLLEGEVVTLICSTRGWYVSKSNVNNFDPSPRPSADGSIPAPTHSLIDLLHSISPLFSERVSRLPPISLDGALADPISTVAIPQATPAYPFLTSPPKPAISPEILRTQLAFLHTGAYGPDLVDAARDWNEEIQGIRELPRGTMQERVFREKMLQKVWAEFDQAAARAVQAVSKGDIPPINPAEDPKAHMYLQSNIFITQGDSDALDTYAHLGGDAAMRISHGKDAAGVKLLNKIDADGLYLLGHTIVDWQGRRWICQSILPGIFSNRRAVEEEKAQAETEAEAETADAVEGEQKKEDWVDVEKPTEKSGSETESDNPMMIYGLDSERPTSVHWDAATHSLLSTIATPLRLAAHTIKDGEGKEHEFYASAEVKGLKGQDGRRYLLDAQRLAPVDVEWLEKDITGPLVGPKKDDESAEEGVQYPHRLVMLRPELIEQFWESELKRWARGVAEKAQAKKAEAEAEAAAAADAEGEKKKEGEQSEIPQEEQSAAASAAAARRAEEDRPVDASLIGDIKQFNLSFNPDAFVEQPVLEAEGQEGKTEIKAAITDESDPSVKAVRDAGLFLRQIAIPAVVLDVLTGNTSGVMDGESLSKHLHQRGVNIRYLGHLASTIIQFSTSKDGAAKEPSGHLAALQSIVLQEMVFRAAKHILRELLYPLQPETATDAVSHFLNCLLGSCLNPAPVASYTPIGINSNEPEPAYVKLTPECLRAQIIKEVKSRFRWTLDESFLESGLRKKQLLRELASRVGFQLAQREYVFSKDQEEEENKREENIKSKEKKKGSKAGAKGETVKRTTTFEGEDVLTLVPVIKSTAPSVSVAEEILEAGRNTINRGKIEFGLDFMLEAIQLYESIHSVIHPEVASVYNSYAQAIHQIARLKIQQIAAQENPDPEQPLGVDISGALRFQRQAVAIAERTLGVYHHETAGYYFQLAMLENLEGNAQQSLRYFRHLLTLWDVIYGPGHPEISTILSNAGIVLQSMNDLSLSLSLQKQAYESTLACFGPNHIQTGQSLHQLVQGHFLAGDMASALETAKQALEIFKARLGEEHNQTKEEAKNVELLTAVIENQERQKEREEAVKKEATERLKMARERIGGGAASTSRPTGIRRLGGAGAGALPQGVRVVDPQTLAALAAAAGQGGNPSANAAAATAGQGEQANGESTGTPQIGERGTESLEELVRYIQGSAPGVGGSAKRGKNALRGKRRTGAKR
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MMAVSQPPSVSREKSALSTTTALPTLPLALQTTASESQSRINALTSALQTMTSTTIAACRNCDGLSRRSRHLDSLTSPASETSALLAQASANLTSTSAVLKDAREQFDTVDDNEPSIERLFWGAREACREVASHAEKQGRGGVLPLTMKRLIDGTDKNTMVRPRSMALNEASSPLTEQELYAGADAMEIVRDAHAYFSKRGEWKSTLDTMKDLERVHQIGVDAMGLLVTGHLTGAGAAVRRKVDGAMVEKSGGKGGKQKNGTRVSAAERAEESAAKTRDRLQEALQNRDLMKSIGEYEEYLPLSTRVVRELRAIFECLGGMTSNGTRLLLSSEAPSRVADPSPSLPPGGKILRTEKVGSGHYTNLTMRSLRTGYPHLDSYGEARKSVAYASVDGYCRQLRNARKKTLPQGSTNAALSHANVDAAARDAVRCIEHTMVVVSGEKSVYRCVISSSHSHDESKGMEPQYRRALVTSYSYVVSAAVDRLLDLIEYTFLREGGCATNLNNSGGESSSGANPGESEMDIRSAASAASAGLRIVDGVRMLGPSLSKLCEVSTLPGNQRGGNSGEATIASALCISLHRSTVKNCSKTLENLARSIQLDPLDGAKHRPSDARVATVSSDVVHAIRVISPFVSAYKSVSKRRALPWDQNIGESAAEMDTFVRFLVKQLIISLQGKAQNYKLDGGGGPDASAKGNLFMMNNTFYILDLLGPVANPSEISSDELGGENYRINAPWFKTKIAKIFDNEKAKYLTHWETLNKHLTAVDNREMIYQNNKDVLSLESGRLLKSRFSGFIEDFERVYLVHRTFTIIDPNFRDMLQNDIRGVFLSRYNAFYDKYSRIQFSKKNMETYLKYPPQKVDTLISQLFAKQ
The following text describes a protein:
Function:
May be involved in 20S pre-rRNA processing.
Sequence:
MASQQALQQAFRVVVENVLNRWTALRLAVEHGMGGPLGLNTAIELIDYVTSYCTENKNVDAIDLREVLEEILDQEFETICEDESTQEVSAVLIKYLRMLKEGKEEEVKAELHTMVPCEMWIVSGAKIKYQPIDDSGSESEEDINDPEDMDVEPAPAMDVGSEQVNPSTCGSSTKFIEEEAIDPGWTQVRGRRRR
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase (By similarity). Required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons (By similarity). Promotes the phosphorylation of UPF1 along with its interaction with key NMD pathway proteins UPF2 and EIF4A3 (By similarity). Negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex via induction of N-terminus conformation changes of the RUVBL2 subunits (By similarity).
Sequence:
MPPPRTREGRGHRDRDHHRAPREEEAPEKWDWNCPETRCLLEDVFFRDEDYIRRGSEECQKFWAFFERLQRFQHLKTSQKKKKDPGMPKHGIAALADLPLTYDPRYRINLSILSPDTRGRHGPGRGLPPERVSEFRRALLHYLDFQQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSHAPVVQVPGRLFPITVVYQPQEADQTASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMAEITTVLDAAQAYASLTQRWVVLPLHSALSVSDQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAPYPVPEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPPASVETAILYLQEQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNLDCATARRPLESDQGDPFTLFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQFKELLEDHGLLSGAQVVAPGDSYSRLQQRRERRALHQLKRQHEEGGGRRRKVLRLQEDGCSSDEEDRKGSTSQRADSVDIQDVKFKLRHNLEQLQAAASSAQDLTRDQLALLKLVLGRGLYPQLAVPDAFNSGRKDSDQIFHTQAKQGTVLHPTCVFANSPEVLHTQGQEASGQEGSQDGRDQMSCKHQLLAFVSLLETNKPYLVNCVRIPALQSLLLFSRSIDTNGDCSRLVADGWLELQLADSESAVRLLATSLRLRAHWESALDRQLARQAQRRKLEQEEDVGSPAVSPQEVAALSRELLQFMAAKVPYRLRRLTGLEAQNLYVGPQTITTAPSLPGLFGNSTLSPHPTKGGYAVSDYLTYNCLTSDTDLYSDCLRSFWTCPHCGLHMPFTPLERIAHENTCPEAPGDDPGSEEAAPAPPQKTSALQRPYHCQVCGQDFLFTPTEVLRHRRQHV
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Does not demethylate H3 'Lys-4' nor 'Lys-79'.
Miscellaneous:
MISCELLANEOUS: Present with 784 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The JmjC domain mediates the demethylation activity.
Sequence:
MQDPNICQHCQLKDNPGALIWVKCDSCPQWVHVKCVPLKRIHYSNLTSSEVLSYPNSAKQIKSYRCPNHKEGEYLTAYALITQKGKRQRNKENPEDSHINKRYNFRKKKLLDYIALNEGESKRDKMNHPHKESFMKSFEKWKNGSNIINAADFAEKFDNIDVPYKIIDPLNSGVYVPNVGTDNGCLTVNYITEMIGEDYHVDVMDVQSQMNENWNLGSWNEYFTNTEPDRRDRIRNVISLEVSNIEGLELERPTAVRQNDLVDKIWSFNGHLEKVNGEKAEENDPKPKVTKYILMSVKDAYTDFHLDFAGTSVYYNVISGQKKFLLFPPTQSNIDKYIEWSLKEDQNSVFLGDILEDGIAMELDAGDLFMIPAGYIHAVYTPVDSLVFGGNFLTIRDLETHLKIVEIEKLTKVPRRFTFPKFDQVMGKLCEYLALDKNKITSDVSDGDLLSRTTNCAIQSLHAYVIKPEVKYKPLNFTSKKHLAKALADLIS
The following text describes a protein:
Function:
Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGRDNRGAGGGGGGHQPLSNAMGKLKEKLTRVGDELGYHRVESNLSTSNTATSLDTILPEDPFLFPQVSPQRHPQTVRTQRLLEDEPPLSFRPLLEDDDINEPPTQQPHRSPLRASGSLELTPLPPPPTSLEIREHRDRQQRGAQGDELQRSKQSLKGSRVSFERRDTGNSNTNNNKAAESSDEDSFEEKRTGFQQQKATSVDHKGILKDLKHILANDNRRQFQAKKHVSLDVKGTRFLQDLLKESSSEEEFHKTRREFQGRKHQSLDPRVTFKLDKVLQGSSTDSDEEGEDAEHKRLIHRPKDITKPVIIDLKDLESESDEDFLTSRQHFQQQRSISTDSRKSRRLYEMDEMGNKRGENIRHAVPFVRQITEDGKPKLEVYRPTTNPIFIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRWFVSRGREERARKALSWLRGKEADVEPELKGLMRSQADADRQATQNTMLELLKRNNLKPLSISLGLMFFQQLSGINAVIFYTVQIFKDAGSTIDGNICTIIVGVVNFLATFIGIVLIDRAGRKILLYVSNIAMILTLFVLGGFFYCKAHGPDVSNLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWSCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDIERKMMGRVRRMSSVANIKPLSFNM
The following text describes a protein:
Function:
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Sequence:
MGIKGLTKLLADNAPNAMKEQKLESYFGRRIAVDASMSIYQFLVVVGRKGTQMLTNEAGEVTGHLQGMLYRTIRLYVFDGRPPDLKKQELAKRFSKRAAASEELAVTIAFENKEDREKFSKRTVKVTQQHNGDCKKLLRLMISQLLRLQFCLKSLFVVYAVASEDMDSLTFGAPIFLRHLMDPISRKVPVMEFEISKILEEMNLDMDQFVDRCILSGCDYFESIQGIGGLTALKLISQHGSIENILENINKQRCFLFSDFVPRLIPDNWPYSEARLLFKGPIVSTEEQPEIKWTAPNKEGLISFLMNENGFNIDRVTNAIEKIKAAKDESSQGRVGSKCTFQFPSLAFKPKIFSTQVSVNPQPRVLGSFKMPTVVLGLRNFKQPLRVVCMLTWI
The following text describes a protein:
Function:
Plays a role in the regulation of membrane potential. Could mediate a proton leak. Regulated by the spc1-atf1 pathway and so expression is stress-induced.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MALTGSDIFKVIFAIILPPLGVFLERGCGADVIINILLCCLGYVPGIIHALYIILKY
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAQGDYIELHQKRHGRRLDYEERKRKKEARQVHKRSKQAQNSIGIKGKMIAKKNYAEKAQMKKTLKMHEESSSRRKADEDVQEGAVPAYLLDRENTTRAKVLSNTIKQKRKEKAGKWEVPLPKVRPVAEDEMFRVIRSGKRKTKQWKRMVTKATFVGPGFTRKPPKYERFIRPSGLRFTKAHVTHPELRCTFCLEIIGIKKNPNGPMYTSLGVMTRGTIIEVNVSELGLVTPAGKVVWGKYAQVTNNPENDGCINAVLLV
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.
Sequence:
MAAPRAPLHLVAPRWNAGTRGIRGLSRAAAPEGNQKKGRSLLQFLADRFYDVQALREYLLRKQAWKMHQKNRPFTYIRERYGPYAAGAYFILKLGGAVKFQGKEWIRSNARGHFSLDFLKLQTVPVEAVDASGCAVNYQGLDSLLALKELQVLWLQRCPHVDDWCLSRLHPLASSLQELSLAGCPKISERGLACLHHLQNLRKLDISDLPAVSNPGLTQILVEEMLPDCKVVGADWARGLKVGQEEQYQDITSPIPA
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue; Suggested to catalyze the deposition of the aromatic residues of suberin on the cell wall and thus play a role in cell-suberization.
Subcellular Localization:
Secreted.
Sequence:
MGFRLSHLSLALSFVALALAGVAIYRNTYEAMIMNNGSLLQNVSPNFDSLESGVASILTLNNKKRNSDKYLRQQLTPEACVFSAVRGVVDSAIDAETRMGASLIRLHFHDCFVDGCDGGILLDDINGTFTGEQNSPPNANSARGYEVIAQAKQSVIDTCPNISVSCADILAIAARDSVVKLGGQTYNVALGRSDARTANFTGALTQLPAPFDNLTVQIQKFSDKNFTLREMVALAGAHTVGFARCSTVCTSGNVNPAAQLQCNCSATLTDSDLQQLDTTPSMFDKVYYDDLNNNQGIMFSDQVLTGDATTAGFVTDYSNDVSVFLGDFAAAMIKMGDLPPSAGAQLEIRDVCSRVNPTSVASM
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Sequence:
MWFACLRPLPTTSKFRCSNVFGSKSRQCLPRAVNVKLKPLVRMRSSHSLAERELRSLLPTMEELGLREGDHVTVGMSGGVDSATTLRILREFPIHLDVVFMRNWDPLLSESPPESSLPPSPISLAYSSGSTSNREQNLSPCQWERDWNDVLKVATQVGIPKDSIKLVDLSKEYWSRVFEPAVGVWERGGTPNPDVDCNREIKFGALLDVLPKKDRHFLATGHYGRVAHVPLLSHPGPSKLLRAVDKSKDQTYYLSQMTEQQLSRAILPLGSLLKTDVRRLAEHWGLPNAKKEESMGVCFIGERGKFGDFISQYTSPPESGYLVNLSGERLAEHKGLWYYTIGQRARVANQLKPMFVAKKGVGEKGTDILVVPGSDHPMLLCKSVHTSDFHWIHDTFPRELLVKEPEKVGIQVRHRMNPVGGRIVVGGNVKDVTVEFNDPIVGVSPGQVVAIWHDGWCLGSGVIDGTKCEGENMRGGTG
The following text describes a protein:
Function:
Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRAVNFMYSSNNPKFRGIFNGLCAIILFIFFFDQSDIYRNPLLKNLSFVDSSGKFNRGFSQFTVPRRHLSEVDTNGSSGNSSLSGDSTVSCSGLHEHRGYADQCEFLKSNPICSPDGFFDYLKFFYCSCRDFKILGYILLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGSDKGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVKIDKKCFIRDLSFFLFTLVALMVILMVGKVTVGIAIAFVSIYVFYASLVAANEILRKHSRRLKLDSITPLLPMQGSVFSSPSVEEDIPMYSPLMELDTGEGPPRLHDSLPQWMWATNVAIYSNHFAKANVHDEERPPWGWTEDGAEVESSLCSKITSLLETPLTVPRRLTIPLIEEDSWSKTYAVASVSLAPVLLSFLWSSQDDTSLQARIVAYFIGIAIGSTLGYLAFKNTEPDRPPQIYLIPWVLGGFIMSIVWFYMIANELVALLVTFGGIYGINPSILGLTVLAWGNSMGDLVSNIALSMNGGDGVQIALSGCYAGPMFNTLVGLGMSMFLGAWSKSPETYMIPEDNSLFYTLGFLIFGLIWSLVMLPRNEMRPNKVMGIGLITLYLIFVTFRLSSAMGFIPWAS
The following text describes a protein:
Function:
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Presynapse. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity).
Sequence:
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINSVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKVITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPTKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKTQPPPSQPLPQSQPKQPQAPPTSQQPPSAPAQALPTQAQATPQHQQQLFLKQQQQQQTAPPAQQPAGTFYQQPQQQAQAPQFQAVHPAAQQPVIAQFPVVSQGSSQQQLIQNFYQQQQQQQQLATALHQQQLLTQQAALQQKTTAAAAPQPQAQPAAAASPAPAQEPAQIQAPVRQQPKVQTTPPPTIQGQKLGSLTPPSSPKAQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRASQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKYPEKLGGSAESLIPGFQPTQGDAFAASSFSAGTAEKRKGGQTMDSSLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLIDCSLLSNPTTDLLEEFAPIAISAPAHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
The following text describes a protein:
Function:
May be involved in sexual development.
Subcellular Localization:
Nucleus.
Sequence:
MAKAGKAPLLPVPRGPGSAALPSLLYLRAAVPVYPRAPKCARCRNHGAVSALKGHKRFCRWRDCACAKCALIAERQRVMAAQVALRRQQAQEAEAVEDAEEEHLLREEKIQKTDFYSKELGSSVVHVPISSMTSSPETTGGHKEKPLGVQSLGKEATMVQPSSPHESLEGTDSSTSLSSSDMESGNESECPRDLAAFPIRVSAAGSSSSAASRRRDPLDILIRVFPNHKQSRLAKVLHFCRGDIAQAIEQILNMNEKEQEFGGREFLPLPQCSVIQRSSDFNLLEVDVKAFGGTSAFAPLQTNPSSLGSEVNFYGLNPRLGFRPLRLAYSSPGRAVPALMSPYLRTGLFPALPFHPAVDCSFSGVTKDAPYFPNKDMIISSKIYTRLNETNST