lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Controls the length of the flagellar hook.
Sequence:
MRVANMNVNLTPPVEPSKIAPTAKSSAVSTDAAATESSGGFFAQLHALIFGSKTASDAPATSVTQTEGDTEAPVNTEAVLEADSDAALMAEMDDALFSASEVEAASEEGLPVDVIKSAQKAPSLEKGEAISTKVAPVKQDEQGANAPIPASLAKWVTNAESIDDQPVSGELQRKTAQAMSEGDELLGRLQEANQALIKTNGKILPAQHGQALDSQHPDRIRNATPPEAVLPIESATAISNRALSTSADLDAAVSDSAATEDEIAQDEWMASALMGGALVGGLSGASLAAANTVHAEPVEGAMLEGMPLTQTFANTAALASPSAEVSEALAASSQALKATPLTQSALNPASIMADEGLNQSTSATETGKVVIPWGTQMPTDNELAALTPELKAMLEEGGKAKAPVPNALAQSVAQGLTPAHLAAQQTGTTALPMNPTAATPIDIAALAPQTVAVNPMLNPAATVNPELAASSAMLAALGGRALAGSDERRAVSESGQEDLAQQIAAAAGQGTAQNQALNRAESQLVQTNATPVPLNKEMAADQLAERVQMMMSKNLKNIDIRLDPPELGRMHIRMNMQGDGATVHFTVANQHAREALEQTMPRLREMLAQQGVQLGDTSVQQQSAGQQQRYTGQEQSGFGQSARNERLNSEENLDTDIKLDLNVATKRDGISYYA
The following text describes a protein:
Function:
Involved in protein export. Participates in an early event of protein translocation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMIFLTFLHILVCLALIGIVLLQSGKGAEMGASFGAGGSQSVFGASGGTTFLSKLTTAAAIIFMLTSLTLAYLSGRAETSSIMPAKGVSAPAPKPAAPPAQPQQTQPAPAQPAVPAPAAPAK
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor.
Sequence:
MGIPSFFSWLVGKYPKIVGTIIDVYSASSSEDEEEEKEEKEEEEGEEEEVEEDDDEEDEDEEEIIYDNLYLDMNEIIHKCFRLNNGLVYNWFFAYLDRLFRMVRPRRLLYLAVDGVAPMSKMTKLRQRYFKTAKYRADSEAEAILLTEIFRAQGKEVMPRDTYELQNPVVKVPGTEFMEKISAALEYFIHERLNTDPEWKDIKVILSDANVPGEGEHKIMSFIRAQRSMENYDPNTRHCLHGHDADLIMLALASHEVHISILREFDNPNGRIPARFYQFVDIWVLREYLELEMKTPGCKQDTERLIDDFIFICFLTGNDFIPRIPSLEINEFAVDLLIEVYKTTFNKMGGYMVNTDKIKDKYGVYLEVTRLEKFFHELSLCEEKILLKRYELQEKLLHKIQGEAAVNEWAKGEDRGEKKTSFAQHFFYPVETSLERDSDDVVRENTRELWRTVSDIFCNKDDLFKNGACKQDKIRPGWKSRFYREKLGAETSKEVGRLQTEMVQKYLEGLCWMLQCYFSEVPSWTWCYPFYYAPFASDFKCLSQFNISFTMDKPLRPFDQLMAVLPPQKNVLSCALPKCYSKLMGCEESKIQMSYPTEFEIDPDGKRFLSQGIAKLPFIDKELLLSATKMVEKDLTEDEMARNNARQERIFLRNSQSLANTAAFAATILDNAQKKLWIDASEIGGWFSPDEKEVQSSALRKNKVQHA
The following text describes a protein:
Function:
May be involved in protein trafficking.
Sequence:
MKMHFCIPVSQQRFDALGGRYVLYSVYLDGFLFCRVRYSQLHRWNEQLRRVFGNCLPSFPPKYYLTMTTSMADERREQLEQYLQNVTVDPNMLRSDVFVDFLKLVQLDTFSITTKKVPLDVLLPDERSIKVEILTSDTAERVLEVVSHKIGLRRELVGYFGLFLIRFGKEGKLSVMKKLVDFELPYVSLRSSQVENCKVGLRKWYLDPSLDSRLMDCKAAVDLIYMQAIQDIKKEWAKPTAVQRQKLEALQKEDNQTKFLELSRGIRHYGYIQLDPCTCDYPEPGCGALLSVGNNEISCCVTLPDNQTQDVIFQMNRVKCWQVTFLGTLLDRDGPQQTLNQNLELRFQYSEGSRWQWFVIYTKQAFWLSSCLKKMISEKMAKLAAENPEMQIEVPEPGKSKKCHLPQSQQKDISSFLPRKSKIKIAEVDCGFGTTKEEDL
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKTINKYRLERTSIVKFAITIKLIIWIYCLIVSQFLDNFDSSTNLNSLSPFNSSSGGITFNSTVDASANLNRDFASVETLKNHDGSPIVNLLIKRIFVKWDSIYFIRIAEFNYEHEQNHAFFPLFPISMNLLARVLSYITFSYLSFSDYIIISGFLISNISFIISAVKLLKLGYIIFNNSDFVYTSVLLYCINPAGIFTTAIYTENLFSLMVFSGLVEVYGGDYYLTRELGTHSMPLKEKIISTSKAAIYFALATATRANGFLMCGYLVYIYYSQYITHLARLVLRFSSPLLLLSKRSGKYLMRPSNSFDKLPVVSSDTSSILLDFIVYPVLILIQSFIVILPYFAFQYYGYSRYCTTPPDSNITAFDYSLNKNGDWPRPWCIVDPNSKFSYPNLYSFVQNNYWNQGFFNYYELRQIPNFLFATPMVAISVCSIVSYLFYYLRQPNQMIYPTFKSRSKNITEEITHKHFFFLGYNSNTSETIFYTPHILPFIVYLAFLTVFSVTFMHVQVITRFFIHSPLIFWYSAKFFMKYIPTMVPSSSPRKIDRKNSSPTLSLTSSSSTITQLVSDDQEKNFKLKRNLILIYFIFYNILGSVLFINFYPWT
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHVAKKSLASMAASATTTILVAAMLVVMAVESPVANGQAAAAAPAPAPAAPKTITAILTKAGQFTKFLQLLQSTQAGEQINNQIKGKASSSGGLTVFAPPDNAFAALPTGTLNKLSDQQKTSLVQFHVVSALLPMAQFDTVSNPLRTQAGETAAGKYPLNVTAEGSRVNISTGVVNATVDNTLYSGDRLVVYQVDKVLLPWALYGPPVPAPAPSPADKAKKKAGPVGVADAPAADTAAGTTTTTVATASEAAARGTVRRGLVGVAVAVAVAWCGM
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSEIAPGKLRPPVWDVQEHNIQQLSKNSQEAARETLCLSNNQAVKLVENLYGFNVESVKKLGSYGDYNFHVKVSGADLEHHEYILKVMNAKDSRDEEQITAQTSMMTFLSTRDFHVPRPEQNRWGNIMSLVNFERKENGTTVSTDHNVRLLTYLSGILGSDVTLDPASLYGAGVYMARLHQALKNFDHPGLHRPNFKWNLRNTSVVGEYLHVLGSIEDQKMAHKVLDLFADKVLSRMEDLQQGPTHADFGSGNILVKEKTTNPGPEERYQICGVLDFGDAIWNPLVFDVAISLLFYMLTAPDHEDPTVYSGHFLRGYESVRPLTTAEWDVLYHCVVERACQLYVLNERAVSVEPDREAHIRQDCERLYETLKYLVESPKAEIDKQMLGR
The following text describes a protein:
Function:
Transcriptional regulator essential for Nod-factor-induced gene expression (Probable). Acts downstream of calcium spiking and a calcium/calmodulin-dependent protein kinase required for activation of early nodulation gene expression. Transcription factor involved in the induction of NIN and ENOD40 genes, which are required for rhizobial infection and early nodule development. Does not seem to contribute to the early steps of the arbuscular mycorrhizal fungus infection and colonization processes in roots. Transcription factor involved in the positive regulation of the beta-carotene isomerase D27, which participates in a pathway leading to biosynthesis of strigolactones in roots.
Subcellular Localization:
Nucleus membrane. Endoplasmic reticulum. Note=Mainly localized to the nuclear envelope. Also found in the endoplasmic reticulum. Upon Nod-factor application, the nuclear envelope localization disappears and the protein accumulates in the nucleus.
Sequence:
MEMDIDCIHHLDFSGHSTLTNTPSSDNDNYGCSWNHWSPVVNWDAFTGNQDDFHHLIDSMIDDNNTGPAFSDHTASTTSEEEEEEEATTTTMTTTTTTTTTTPEAADDDFKGLRLVHLLMAGAEALTGANKNRELARVILVRLKELVSHTDGTNMERLAAYFTEALQGLLEGAGGAYNSSSKHHVIGGPHHEPQNDALAAFQLLQDMSPYVKFGHFTANQAIVEAVAHERRVHIVDYDIMEGVQWASLMQALASNPNGPHLRITALSRSGVGRRSMATVQETGRRLTAFATSLGQPFSFHHSRLESDETFRPAGLKLVRGEALVFNCMLNLPHLTYRSPNSVASFLTAAKALRPRLVTVVEEEVGSALGGFVERFMDSLHHFSAVFDSLEAGFPMQGRARALVERVFLGPRIVGSLARIYRTGGGGEERGSWREWLRAAGFSGVAVSSANHCQSNLLLGLFNDGYRVEELGSNKLVLHWKTRRLLSASLWTCSSESDCA
The following text describes a protein:
Function:
Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as a component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase ypt7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. Acts as a component of the CORVET complex that is required for transport between endosome and vacuole. CORVET is an effector for the endosomal Rab GTPase ypt5. Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MSTFIKNWKRITLFQVKAIEENIDRLTSSFSSNGELVVFATAFGDVSIYNSSFKSLQSIKVEDESSIQQILWLDNKTFLLFSNVEGGTGTNSTVIIYAFSQADENEPPQFVLVTTHKFSINESPYPIIAVSQSPIDKTIACGFGGGLVSCYHGNPLRERGIKNSYSHNLGEPITGLTYLDDQSSVLFIATTNKTYSLSGKSLSCLDNTGVSLNCSSSCKTTPLQSREKNSSSFVCTRSSGLTFYDSKREKICFTFPGEKHYMTVMGSILALCYTPTLGTDSSTNEGLKKSFSSSSSIRKADASRNPAFPPRLLLVDLSRNLIVWEGHLKDVAVSILPLKHGFLVVTADDNVFELKRITLQEEISLLCQKMMYNLAISLAKKENMDIEFRESLMRDYASFLFRRGDFSASMDWYIRSIKSIDIPSVCLEFLKAQEIKQLIRLLEELIKTGLATSDHRLLLLSCYVEIHDSPSIRKLIDIGEIDFDQAFKICYDSNLLDEAKHLAIRFNNNERVLDVLVESEQYSEALRFFESLPPSNLLPLLLKYGRVLLDKLPEKTTNIFIQFYSNSHRGDLSTSESKGELKTAKSLRQTYLSLLPYAQVANFSLPPSLYEISPSQEENQRAALFSEDVSYTAPSPQTCFHIFLNHNSELISFLEGILPNASPNYKTLINTCLFEAYIRESFASSNVEKQEFWQEKSNSLLKKVEKNVDLNAVFLISQILGFDDGVRFVQGKSGQTLDIFRSFCQQNDIERALKMVRVHGPDQQELYIMMLNCFASLENVDSWYQDINEIVNIIVSQRLISPTQLLDILGKSVNIKLEHISDSMQSVLDNYRESISKQNEAIEMGKRDIEEITSQLSILRTRAFVVQESKCSTCGIDLELPMVHFRCGHSYHQRCVEDECIRCRWL
The following text describes a protein:
Function:
G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane raft.
Sequence:
MRLNGSAPGPRGAAPGAKPFPLPPSGLEAALLVPGLGLGNGSGNESERPRAAPSSDLDVNTDIYSKVAVTAVYLALFVVGTVGNSVTAFTLGRKKSLQNLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAVCRGYYFLRDACTYATALNVASLSVERYLAICHPFRAKTLMSRSRTKKFISVIWLTSGLLAVPMPFTMGQQNRSTDGHHPGGLVCTPVVGTATIKVVIQINTFMSFVFPMVVISILNTIIANKLTVMVRQAAEQGQVCTVGDQHSSFSMSIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDKQWTPFLYDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQAFLSTLACLCPLWGRRGRRPAFTRKTNSVSSNHTFSSNVTRETLY
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLSRHTVANEYSLGGRDLYKRADQHDPEAVLDGVATAGLVGLLRQLGDLAEFAAEVFHGLYDEVMTASARGHGLVLRVQQLEAELPLLEKDVCQRDYLYVASNRGVDWHANLRVDHGVVTTGDTPRFIMDSIKQCHGPPRLFMLDKYDIGGEGTCMKRYSDPAFFKTDSACSRMLQEGMRTERRPIRTMEIRPNLQNAEIFGPSDGANNGSRFKTDLSDEVLDEVPTRRQRLKHRQLNGTVFRSFRPQMQDLYEKSSPEEKTVSMDRSEVQISFTVSLDTNAEERDIMMDTSSSTGKSKEGYYATTRKRRSTSQETPSSCSDDRSAGSSKGYNSEVDIYVDALTTMGSEVGTDSEHRDHGGQGVFALAPSGKMCSDAQGAAVSRSSTFSKKEDSCSSDVASANRDEADHSEEDASVCVPEAKLVGGEHERTSSLEELFSQEKPVSCEHERTVSLEELLTGDMLLSESDTRELVTESNGNAIVSNATSDGTADATKRSKGNNVSAISFKKTASKRCVESMELFASKVGILPRKLSKKHDPFSDSLRNMAKQLLELKCDGTQDTDLYEFEVNGDGFNVECRKMAHPRVEIMEESFRKSISFDSPQDDVGSRECQLEVVDQESDHDVPTADSPQDSVPDENGFQHTDVYLTVITSPSPKEEEEEEEEGWAVVAPDEHSSAGIVDHASELIQEQTEDIHTEVFSENASDMSEDLKEIRICDEHVYAEDADGCSESEEYASDEEIAEKTGEHVAPDDVISSRISSKQSDDPCQVTPFTLTDADFAVASEGPENYIPEMEHVTLLETVVETGLPKGLTESVISSEAAGPDNEQCCLHPETSLPQDTVLGSCELLDQNEQLQLHSSSMMSAIPDPAVNTGEIHELHEEPPNPCNGISTEIFADQLAPDSRDLPLPSISSFDWMLNGLMNKSLNVVPAPSSNIIDNGSSEDTEEAPPLPPLPPMQWRATKLQTGSISLFAKSGRPPRPKPPVKHQENDNNFALVETNQESENAQEISRNNGFTSQKETAQARVCSETPKDLLPESDSQENNLQEGYRECDVQSSNLFFSSEVKCNTDVTSVGDDAHTMKPPELIVIPEEAWSELVDIKPILKQEEERKQQLINRVSNCSSIHASGLPTEKTTVDHERSDQKEELSAADSNTITDSEENKPNGLPCQDNIQSPDFSVQQEDSSNDMVKEFSSALEEELAKLPPHSVPEPPKYPLLQVISHDRSMLRKAPTLVQPSSKLSDEKNTVLDEIKNKTFNLKPVVAKRPNVMGGPRTNLQVAAILERANAIRQAVADDDDEDSWSE
The following text describes a protein:
Function:
May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.
Sequence:
MGLTYSFSSPSQETGSSIIDLPEDQTVTRSGEGNGHGSEAMARILNDVKQRGIKVLRVEFTDINCITRCKMVAVHSLDELTSNLTRGFLFSPLYFFKDPAGNTFESNFKRKYYFTDFCALPALDTYSVIPWLEDTARVTSALYHLNMTDLVVEHPRNVAEKQLRRLESLGFSLLSAYESEFRLSDAKGQELVAERMSFGGSTVLLLKVKDYIKQLFDCLPQVGVLVNTIHAETSAGALEVATEPSFGIKAADDAVMVRNTCKDIALCNGYTAHFLADPNWNAHGFCLDFNHSLWDKTGNVISNKTGDLTDTAKHWIAGLLAHARALTPLSAPTVNGIKMFGAYQPPNHNEPSFITWGRYNRSVTFRVKSSGGPTGSYIENRLGRSDADPYLLLAGTIAAGLDGIINKLTLPSECTGDAHTDIPPGTPRLPFEMEEGVTALVEDKVLCEALGKDFVDLIVASRRHEIELYNTNKTDI
The following text describes a protein:
Function:
Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to all the MTOCs, including the SPB and interphase and equatorial MTOCs.
Sequence:
MSESTKETIEVLYEIGTLLGTELDKTTLSLCISLCENNVHPEAIAQIIREIRMAQEQTVDTEPS
The following text describes a protein:
Function:
Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis by assisting DICER-LIKE 1 (DCL1) in the accurate processing from primary miRNAs (pri-miRNAs) to miRNAs in the nucleus. Forms a complex with SERRATE (SE) and DCL1 to promote accurate processing of pri-miRNAs by DCL1. Binds and assist DCL1 for accurate processing of precursor miRNAs (pre-miRNA). Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved with argonaute 1 (AGO1) in the guide strand selection from miRNA duplexes, presumably by directional loading of the miRNA duplex (guide stand and passenger strand) onto the RNA-induced silencing complex (RISC) for passenger strand degradation. Does not participate in sense transgene-induced post-transcriptional gene silencing (S-PTGS). Involved in several plant development aspects and response to hormones through its role in miRNAs processing.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing HYL1 show decreased stability of transcripts targeted by miRNAs.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Localizes to nuclear dicing body (also named D body), a nuclear body distributed throughout the nucleoplasm and involved in miRNA processing.
Domain:
The dsRNA binding domains (dsRBDs) 1 and 2 are sufficient for the function in miRNA precursors processing and mature miRNA generation.
Sequence:
MTSTDVSSGVSNCYVFKSRLQEYAQKYKLPTPVYEIVKEGPSHKSLFQSTVILDGVRYNSLPGFFNRKAAEQSAAEVALRELAKSSELSQCVSQPVHETGLCKNLLQEYAQKMNYAIPLYQCQKVETLGRVTQFTCTVEIGGIKYTGAATRTKKDAEISAGRTALLAIQSDTKNNLANYNTQLTVLPCEKKTIQAAIPLKETVKTLKARKAQFKKKAQKGKRTVAKNPEDIIIPPQPTDHCQNDQSEKIETTPNLEPSSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLEPSSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLESSSCMSGLKEAAFGSVETEASHA
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MPASIILSNLSLSTPDGRSLFSNIDLTFAAERTGLVGRNGVGKSTLLASICREHVPTSGRILTNGTVGLLRQDVQLRAGATVADLFGVREALKLLRCAARGDASADDIAAIDWTLEARLASALARVGFDLAPDTELSCLSGGQTTRVRLAALVFAEPDFLLLDEPTNNLDRDGRKAVIDLLAAWRGGAIVVSHDRGLLETMDAIVELTSLGATRYGGNWSRYREQKAVELAAVRHDLAYAEKRLSEIDGKAQEAVERKARKDSGGRKKRAKGDMPRILAGARKDRSEDTGGKTAQVAERRRAEALEAVDTARRRIEILQPLSVRLPSTNLPAGREVVWLDRVSAGYRPERAILRELSFTIVGPERVAVVGPNGSGKTTLLKLIAGEMCPLVGTVRVKPEFALFDQTVSLLDPAISILDNFRRLNPEAGMNACHAALARFMFRADAALQIAGSLSGGQLLRAGLACVFGGATPPSLLILDEPTNHLDIASIEAVEAGLRAYDGALLVVSHDEAFLQAIRITRRLDLAAKVPGADGRIL
The following text describes a protein:
Function:
Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPDISKKRLPCKVLVFNLPPTLPEQVFLQSINSFLPHVEWHRFSKGKATVGTRSELLSFAYLKFQSATAVQEFFRVYQGHTFIDKKNNTYRAIVTIAPYQKIPPSKVKADSLEGSLEQDPKFQEFKVQRESYSQTASNDDVIEKLQTSTPLLQYLAEKKNAVVEKGKSKPSKKSVKAKKKLRLAEKPASNNSKAGKSSQESKKSSKAPAESAAAVIKEDKVSDRKKSKKKPKKTPVSNSTASQASENASDKKTKEKKSSGKQKIASKKKDQLTTDNV
The following text describes a protein:
Function:
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MWQSCSSVNGKPPAEKPAQHRWLKRLVLTVVMNGLSNQEVETLRAQHGFNEVKTNQTPEWKKILWRYLDWVSIIIFVAAIISATVEVEGGRGWTSFVLLILELNLIVWVGYYSERNAGNAVKELEALTVPMAQAKREGKWQQVPARELLPGDIIALKGGDVIPADAQLVGVGEPLLVDESSLTGESLPVTRKPGDQVLAGATVTQGELEAQVTATGADSFFGKTIALLGAPEERGHLQTVLNQVSIAVAVISFFAVLVIVIVLLVDQDASPSYAVVTAFVIFVAAVPVGMPVVTTTVLAFGAREMAAERAIVTRLSALEELSGMEVLASDKTGTLTLNRLTLDKDDILAWGASSKDDVLLTASLSAKWDHNDAIDKAVTEAMGGDAKICFQRLTFGRNRGT
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGWTNGSSTVSYTSFLLLGFPGLQESRALLVLPFLSLYLVIVSANALVTRTVVAQRSLHQPMYLLIALLLAVNICAATTVVPAMLFSFSTRFNRISLARCLVQMFCIYFLIVFDCNILLVMALDRYVAICYPLRYPQIVTSQLLAGLLGVAAARGTCIVAPVVALASRHMALMTLSCGDISLNKTVGLAVRIFNRVLDMLLLGASYARIIQAALRMASAGARSKALDTCGSHLLVIFTVYSSTMSSSIVYRVARTASQDVHNLLSAFYLLLPCLVNPLIYGARTKEIRQHLATLFQRPQQQVPSKKPQPLASQRELPA
The following text describes a protein:
Function:
May act as a polo kinase kinase by mediating phosphorylation of plk1.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MAFSKFGKMFRLPTIEIKKKTKQYNHLQRDVNPNDMWEIIGELGDGAFGKVYKAQNKETGVLAAAKVIETKSEEELEDYMVEIDILASCNHQYIVKLLDAFFFDNKLSIMIEFCPGGAVDAIMLELDRGLQEPQIRVICKQMLEALQYLHSMKIIHRDLKAGNILLTLDGDIKLADFGVSAKNTKTLQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQIEPPHHELNPMRVLLKIAKSEPPGLDQPSKWSMDFNDFLKKALDRHPETRPTAAQLLEHPFVSSVNTNRPLRELVAEAKAEVMEEIEDNHEDGEDEDPADLTPVQAPTKDPSQTSATSLNGDHPHGTCYAETSMEIEEEPSTLESTKTPLKEQEDNLSDKFQVEDHDKPESEASGKASSSDSGIEDGKSTPTSEEDTKTVEASEPELPVQRTPTPAEEPEYPSETMEKYLEKPKEPEKEDHCEETQPVLKRIQLKDPNGRMSVVSNRSSFAGDDAESLVSHTNGRLSNRYSDVASDSMDISLNLSGDLSVNKEMGTISLRDSKKTLKRTRRFLVDGVEVSVTTSKIITDDEKKDEEMRFLRRQELRDLRLLQKEQHRSLTVLNMKLKEQREQMHRRFDQEMNAKKKYYYTELEALEKHQKQTIERMETEHSNSLREEGKRIRVEQEKAYQKFLDQMKQKKKEVKQEVEKMPRNQRKDTMKMKMNNYQQMRSDEEQKFIADQKEYLDVTLKSIISKNKHEISETERQCLLKKQNLVREREATLWDMEEKNLHERHQLHKQQLKDQYFLQRHQLLKKHEKEQEQMLHYNLRMVELLKARQQQERNRLPKIQRNEAKTRMVMFKKSLKINSSGSAAEDREKVKQFSRMEEKRQKAERLHQQQKHENQMREMLSQCDGNTRELQQLQNEKCHLLIENETQRLKSLDEQHNQQLKEWREHLKPRKKVLEDELTLRKRAGAFLQDDG
The following text describes a protein:
Function:
May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL-12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses.
Miscellaneous:
MISCELLANEOUS: Overexpression confers resistance to pyrimidine-imidazoles (PIs) compounds.
Subcellular Localization:
Secreted.
Sequence:
MPKRSEYRQGTPNWVDLQTTDQSAAKKFYTSLFGWGYDDNPVPGGGGVYSMATLNGEAVAAIAPMPPGAPEGMPPIWNTYIAVDDVDAVVDKVVPGGGQVMMPAFDIGDAGRMSFITDPTGAAVGLWQANRHIGATLVNETGTLIWNELLTDKPDLALAFYEAVVGLTHSSMEIAAGQNYRVLKAGDAEVGGCMEPPMPGVPNHWHVYFAVDDADATAAKAAAAGGQVIAEPADIPSVGRFAVLSDPQGAIFSVLKPAPQQ
The following text describes a protein:
Function:
Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May play an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres.
Sequence:
MKRHRASSGKRGETADGGRVKRPTKSHNQQGPTSQKRGTVGKGDKRAQKRKLVTQAVRREDEEHEDSSSAGEKGHSKKVKLSSAKVESWQPLSESSRKFLESVMDSGILSILCQQSKGKEDVQKHLNLLKERVLRVFKTLKVPLGKLSNLNNVLSFQVAQKQMLEMNETALVQLQEEINEAEKSAERTEETILRLQHDIQVLKSQLEEEEKKARKLCREGDTKELHLPELPKCSLQAPTLQEEILMVKNQKGLLEDMNTIQQSADMRNMLTFIEKIYEKVDLV
The following text describes a protein:
Function:
Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group function as pEtN donors and the reaction releases diacylglycerol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRYIKSMTQQKLSFLLALYIGLFMNCAVFYRRFGSYAQEFTIWKGLSAVVELGATVLVTFFLLRLLSLFGRRVWRVLATLVVLFSAGASYYMTFLNVVIGYGIIASVMTTDIDLSKEVVGLHFVLWLIAVSVLPLIFIWSNHCRYTLLRQLRTPGQRFRSAAVVVLAGVMVWAPIRLLDIQQKKVERATGIDLPSYGGVVANSYLPSNWLSALGLYAWAQVDESSDNNSLINPARKFTYVAPKDGDDTYVVFIIGETTRWDHMGIFGYERNTTPKLAQEKNLAAFRGYSCDTATKLSLRCMFVREGGADNNPQRTLKEQNVFAVLKQLGFSSDLYAMQSEMWFYSNTMADNISYREQIGAEPRNRGKTVDDMLLIDEMQNSLAQNPEGKHLIILHTKGSHFNYTQRYPRSYAQWKPECIGVDSGCTKAQMINSYDNSVTYVDHFITSVFDQLRDKKAIVFYAADHGESINEREHLHGTPRNMAPPEQFRVPMLVWMSDKYLASPQHAQMFAHLKQQAEIKVPRRHVELYDTIMGCLGYTSPNGGINQNNNWCHIPDVQKVAAK
The following text describes a protein:
Function:
May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors.
Subcellular Localization:
Early endosome. Mitochondrion.
Sequence:
MDRHVTQPKLIKDWTKEHVRKWITEDLKIDEKYAQIVFEEEVTGMVLQELTEKDLREMGLPRGPALLIKRMYNKLISSPEGHNQDSRQLNNKTLSINEQPKKSNSEEENSISSNSDFGLRETGQNEEQEPSIMKVNTLGDVETKDMKDNMPKSEQMSCMPHPFNFAHDAKRYIEHSILRVAETGPLNLIDPVHEFKAFTNTETATQEQMKMKFSNETFRFAAACMNTRTNGTIHFGVKDKPHGEIVGVQVTSKDIFINHFNVMITKYFEDSDIHEARACIREPRFVEVLLLNNTQSNRFVIEVDVIPKHSICQEKYFYVMLQTCTGTTWKQSKDTSLFVREGASSRDILGNPKQRDREFKKFLENLKMSIASRKAAEECMVVSKKDSEGLKLSKLLTRHQGSLDKSYYDWYILVTNSCVPTQMEHLDFIKEIKLFAVLDFDPYSHIKGVVKAYRESRVANLHLPSHYEEKTTIEEKISTLKLYEQPSWIFCNGRVDLSCQPLEPHLWQRDRASGVRKLISFLTDGNIIARGKVLVVFLLLSPVENQKDPLLETFCAFYQVFNGMDNMLCICVNPSIYQQWSDLLQVRLEIKDDLAKHSISTLNIELVNSTILKLKSVIQSSRRFLPSCGSSSVILEKMDEDIMSALEILCENECRDTDIEKDESQFLEFKKLREEHFYRGGRVSWWNFYFSSENYSSAFVKRDNFEELTTLIQQCADSPKPVFAKVINLYHHPGCGGTTLAMHVLWDLKQKFRCAVLKNKATDFIEIGEQVSKLISYKASSHQDYIPVLLLVDDFEEQQNTYILQNAINSFIAEKGVRYEKTLVIILNCMRSQNPDESAKLADSISLKYQLSPKEKRAFEAKLQEIEKEYKDCENFYSFMILKDNFDTTYIKNVVKNTLKDLDAHSRKAQFISYLALLNTYVIDSTISVSQCEIFLGITYTIKRGKPETVEDNMGTYSTLLIRTEVSDYGRYAGIRIIHPLIAIHCLKELEMSHGMDKCQIALNMLEENIFYDSGIGRDKFKHDVQTLLLTRQRKEHGAEIDTLFSPFIEELQNEQTEKVLTAGSDRFPQNAFICQALARHFYLKEKNFSTALVWANQAKRKAPKNSYISDTLGQVYKSEIRQWLSKNSTCRSISVDDLTRFLEVAEKASKAFKESQEQTDSKDYEIEVWSPQKSQRRYDTYNTAGFFGEIEVGLDTIQLLQLTPLFHKENEMSKESMAQFLSGKGTIPPDPKGEYYVVLNKFKSFLQNLQSDLKRCFDFFLDYMGLLKPRNTPKELTELSLSKKVSRCFKKYADLFCQELQGKEDLLLQEENCRKRIKAWRADTFSGLLEYLNPNHKEANNMENIVEHYTFLLQHTLNKQLSKALIKDTQNFILANIILSCLKPSSKHILPFSTLKKKLREVLQIVGLTHSYPDPYFLACLLFWPENKELDQDSSLIEKYVSSLNRSFRRQYKHMCRSRQPSTLFYLGQKKGLNSLVHKAEIERYFSEVQDSNSFWQSGVVWEKGEVKDILCLLDGQAEGKLISLEYGTEANIKIPMTSVHSGPLRSGRNMERVSFYLGFSIEGPLAYGIKVI
The following text describes a protein:
Function:
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes mainly in the cytoplasm and partially in the nucleus.
Domain:
The C-terminal nitrobindin region coordinates a heme and bears the isomerase activity. The N-terminal zinc finger domain likely binds DNA and may be involved in transcriptional regulation.
Sequence:
MVICCAAANCSNRQGKGEKRAVSFHRFPLKDSKRLMQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLAEKKRRAGGHGRPRRRDTGKASAGLRAQASDPVDGKAAAGSPSSSSASPMAKPEPRKLKRATPQGRTAARAARETAGQERGRQPLEGRAEDGPASAATSCSQGEAGTGAEDAGEEGATPADRGLVDRSGVSADDFTPPGSGACKFIGSLHSYSFSSKHARERPAVPREPVERKRLRRDAEPGCSGSSPGPEKGPAQSPPRACPSASSSLTATPQKPAQGASAPPTDVTPKPAAEAVQSEHSDASPMSINEVILSASGACKLIDSLHSYCFSSRQSKSQVCCLREQVEKKNGELRTLRQRVSRSDSQVRELRQKLDQLRRLSLPHLSSLLPPGREPPKMSPVVEPLSWMLGTWLSEPPGAGTFPTLQPFRYLEEAHISHVGQPMLNFSFNAFHPDTHKPMHRECGFIRLEPDTNKVAFVSAQNTGIVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGNLEQTVSMATTTQPLTQHLHVTYKKVTP
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MFFKSLDLTTALRPSLLPDETLLFVQDAVGLYEGSQCPLPATPYKQPAPKPINATWVCPICSFTNPVPSNFDPATATASTPLSPCLACGIKPPFTTVLKAAITAAASREAAQVHPASHEPGQPESNDDETVRKPNASTPCPRCTFVNHPYLLECEICGAPLAPAVARGASVDGSRRSESPAPVFGQGNIANTETFEVVKLSFRGGGEKTFYERLKGALVQRKWLLYDAPPVPQQPSQSPATPNLTASGAVAANVSTPAQPRSPAVGIAGLEQRGLEARRNNEVVIGSSFEDLEALMASAKRIINLAETLARESGMAGDENTAATNAVLSESAAALGMTTTKDMLGSGAENLYLSELSRDLAEYLTDDNKGILQKEGGIMSLVDLWAMFNRSRNGVELVSPSDFQKAAELWEKLKLPVRLRRFKSGLLVVQRYDWNDEKTIRQLQEWMAELRQIPPADPVPWDWRQFGRAVTAQEAAQRFKWSVGVAAEELEMAEDKGVLCREEGIEGLRFWSNYITSDLSSMNSIDSIDLRVSSLAI