lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably involved in the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSDHQRFSYPIMSIKEEYANLSLKEEYSGFIARKTSFLLAGFIFLLILVTFAVTVGAAELGMKDVFFAITARFSSLNVSDFTYGVVWHLRLPRLFLGVVAGAGLAVSGCVMQGITRNPLVSPFTIGISSAAAFGASLAIFLGSGLASGGQLFVVANAFVFALVCAFSVFGLANLRGSSPETLVLAGIAISYLFSALAAVLQFFASEEKLMAMVHWSFGSLTNSDWDSIAIISCTMLFTFPVLMRYSWDLNTIMLVDDGTAKSLGIHASRVRTTLLIISSLITATIISFTGIIGFVGLVAPHVTRFILGGDHRFLLPGTCIAGSILVIMADITGRCLIPPIVFPLGVVISFVGVPMFVYLLITEKEEFWK
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MAAAALRAQLNAHIAGMYTVGVVDEDTFEELWDEGTAVEVSRLFIYDASKIINDIDILMEEPEVDFDEVEALTQQLMRCTSRCLVSLALVRNEFYIVRHELEIMMQLEEQIAACGPNS
The following text describes a protein:
Function:
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Subcellular Localization:
Secreted.
Sequence:
MRLLLLTFLGVCCFAAWVVEGVGTEVLQESICVSLRTQRLPVQKIKTYTIKEGAMRAVIFVTKRGLRICADPQAKWVKTAIKTVDGRASASKSKAETIPTQAQRSASTAVTLTG
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent oxidation of D-arabinitol at carbon 4 to produce D-ribulose.
Sequence:
MDSSSYWSYDNIVPSFRLDGKLVIITGGSGGLSAVVSRALLAKGADIALIDMNLERTQQAARDVLQWGEEQMKGKHESPIGQVSAWSCNIGDAEAVELTFKAINEHHGKVASVLINTAGYAENFPAEEYPAKNAENIMKVNGLGSFYVSQAFARPLIQNNMTGSIILIGSMSGTIVNDPQPQCMYNMSKAGVIHLARSLACEWAKYNIRVNTLSPGYILTPLTRNVISGHTEMKTEWESKIPMKRMAEPKEFVGSILYLASDSASSYTTGHNLVVDGGYECW
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MEEFENFFSQLIPAPDQDIWLLAAQQTPQNNDGVSTSGIPIGWSLQNLAASTNNIAAIDSNPQIREQLQQLQQQQQQQQTQIQQQLQSYQQQQQQHYQQRQQQYQQQYQQPYTTPSPPDQIDYNQQLSPQQQQQQQQQQQQQQQQQQQQPQLQQQNNTISQQQQQQNLNFQVQFLQQQQQHQQQLQQQQEQFQHQQLQHQQQQYFIKQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQHLSPILSPLPPIQQLQQYQQQQQQQQQQQQQQQQQQQQQQPQQQSINIGSSNTPLQHQAMLQAQSLMDSINTKQPPIPPTLQSPTQHQFLNTPVLDQHILSSIRPSYSQVTKANISTLPTEITNSLTNFNGTNNSTPNFEDLTGGKLSSNNIKNTATPLSSPPSTKNGKQKQPKNNNNNNNSSNNNNNNNQTTTQQKQSKNNNSYGNNSNNNNNNNNFNNNKLKKQNDSTTTPTITSPNMTSPIDSNGDFDLLDEDEKKKSISRINQNLASRNYRQRRKEYIKEIESKMAALTFENHQLKKENESLKETGGVEVMRPEPELITMVVEGKQIIIQLSQALKKNDDRSLIYLLHLYHCAIAKRYSIVEREVEKIVHPYTQSKLAAMGYIPKSDKMFLNCIAGPAADSWFQLFKNEAEITLEQSNKLEALRTQHGKIDSALLQERQELDLDIKKFYYTKILVLPNNPLIIGDIPAQPYNGELSQSPISNSPLEISQLLDFAGKLESLKKNFILHRNLMLDTLASLSSILTPRQEAMLLVRVHFYTSYDFSHMELLKDVWTNIVSSKSITGPLNISEALKKLSDTTNTHHSIENIVKPPQFHQYTPKQLKFENQSNNFGNNNGSKSKNIENNLNNSVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNSNNNNNVNSNSSNVNSNNNNFNNAPQMVLNPPSADAIPYPSTTQLDKRFQWVSYPSAPPPN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Domain:
The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.
Sequence:
MQGSVTEFLKPRLVDIEQISTTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIEGVLHEYSTKEGVQEDILEILLNLKGLAVRVAEGKDEVFITLNKSGSGPVVAGDITHDGDVEIVNPEHVICHLTSDNAAIAMRIKVERGRGYVPASARIHTEEDERPIGRLLVDATFSPVDKIAYSVEAARVEQRTDLDKLVIDMETNGTLEPEEAIRRAATILAEQLDAFVDLRDVRVPEEKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIAED
The following text describes a protein:
Function:
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSPNGSDRSPRRPMRRKLLQALTAGLVLATATGCTYEDFPRLGMPTPTTEEAPRILSLWQGSWAAALATGVLVWGLILWSVFFHRRSRTKVEVPPQTRYNLPIEALYTMVPLVIVSVLFYFTARDESDLMSLNKKPDLTVNVVGFQWSWCFNHIEDVPGSTGDAKTSKELAGIPDRFIEDFPANAGGVYDCGTPGTENPQTGNPGPTLWLPKGKTVRFVLTSRDVIHSFWVVPFLMKQDVIPGHTNAFEVTPNKEGTFLGKCAELCGVDHSRMLFNVKVVSPERYEQHLQDLAKKGQTGYVPAGIAQTSHEKNRETNNL
The following text describes a protein:
Function:
Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Required for ciliogenesis in multiciliated cells.
Subcellular Localization:
Nucleus.
Sequence:
MFDLPRAAPLDMADSWLTFQAEEEQGQESFSSSVNLDDSLTSLQWLQEFSILNSNEGKTPSSSGDSHGYRQLSGAPCSPLAADPACLGMPHTPGKPISSSTSRASHLGLQPMEEIDYKTNPHVKPPYSYATLICMAMQASKKTKITLSAIYNWITDNFCYFRHADPTWQNSIRHNLSLNKCFMKVPREKDEPGKGGFWKIDPQYADRLINGAMKKRRLPPVQIHPAFASAQAAASSDSKRGSAWQMSVNSESHQLLKAFEEITNEQGWNPLGEHGWNSISDGKSHKRKQPLPKRMFKAPRLSSSPMLSQEEQTELGSLKGDFDWEVIFDSSINGFNFSAFEDLEVTPPLSPVTRSVDLTVHGKHIDCPQQWYPMGQDHAVAQNSLDFDETLLATSFLQHPWEENRNDYLSNSANIEQLFDLNEAFPAELNDWSSLGSYI
The following text describes a protein:
Function:
Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.
Subcellular Localization:
Cell membrane. Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus. Synapse.
Sequence:
MDPAGGPRGVLPRSCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTRLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRAGSKTPVSPVVVQQGPVDAHLVPLEEPVPSHWTVVPDQDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYISGWGIDG
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MSDPTSKPSIPKWQQQDSGSSPSTSDEKNADYGDRSTLLEQASSFLQDDSIRDAPTDRKIAFLESKGLTDTEIDGLLGVSRNAEASSGSGSGGDNSVEERKSTSAPSTETFNPAVSKPTPPTPSSNSRPVNLTPRDVPPIITYPEFLLHQSKPPPLVTLRSVLYTLYTAAGLGATLYGAGEYLVKPMLAALTDARHDLAQTTEENLKKLNEKLELNVSQLPPSLITKSTASVGDATEEDIESITSDPTELFHRDIGTQTSQDLIQTSSATSTSATIESTSNDPTTVVTTHQKRLETIGSHLRELEDAQSQSSTLHDTTRSRINDLQHYLDRLMYSKNSYSYSSTMGYGSYSTPGLDSGGGAALGVGKAEEDAISNFRAEIRGVKGALLSARNFPSGRSVGLRSSFVR
The following text describes a protein:
Function:
Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation.
Subcellular Localization:
Early endosome membrane.
Sequence:
MSGTSSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDIIEQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRFCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPATSNQAGNNNLGGSVSAPANSGMVGIGGGVTLLPAFEYRGTWIPILTITVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITSMIEGELGELETECQTTTEEGSSPTQSTEQQDLQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSVQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPVVNVPVPVLIGPISGMSRPFVRTDSIGEKLGRYSSSEPPIVTDELEDLNLWWAAWNTWYRIGSESTKPPITFDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHSAISVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLRVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNENIDVEVVQLISNEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPASRVQNGES
The following text describes a protein:
Function:
Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted. Cytoplasmic vesicle. Note=Located on plasma membrane of spermatocytes, round and elongated spermatids, and testicular spermatozoa.
Sequence:
MGACRIQYILLVFLLIASHWTLVQNIYCEVSRTLSLEDNPSGTFNWTSKAEKCNPGEFCQETVLLIKAEGTKTAILASKSCVPQGAETMTFVQYTAPPGLVAISYSNYCNDSLCNNRNNLASILQAPEPTATSNMSGARHCPTCLALEPCSSAPSMPCANGTTQCYHGKIELSGGGMDSVVHVKGCTTAIGCRLMAKMESVGPMTVKETCSYQSFLHPRMAEIGASWMPTSLWVLELLLPALSLPLIYFP
The following text describes a protein:
Function:
Functions in association with RUP1 as repressor of UV-B-induced photomorphogenesis mediated by UVR8 and HY5. Plays a crucial negative feedback regulatory role downstream of UVR8-COP1 to inhibit UVR8 function, balance UV-B-specific responses and ensure normal plant growth. Is involved in the regulation of photoperiodic flowering and vegetative development. May act as negative regulator of photoperiodic flowering by suppressing flowering through the action of CONSTANS (CO) and FLOWERING LOCUS T (FT).
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MNTLHPHKQQQEQAQQQEEARYEWDLSLSTVVSSSSSSASDVIGAIEFDPTDNIVATAGISRKIRFYGLPSLLRNNAVSGTGVSFVDQATACEYYICTPAKLSSLRWRPGSGGRVIGSGDYDGVVMEYDLEKRTPVFERDEHGGRRVWSVDYTRHGGASTVGASGSDDGTMQVWDPRCPPEESVGVVRPAGICRSAVCCVEFDPSGGPAVAVGCADRKGYVYDIRKLVDPALTLQGHTKTVSYVRFLDGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHVNNRNFVGLSVWRNGALFGCGSENNRVFVYDRRWGKPVWVDGFEPVGMNSGSDKRFVSSVCWRQSGVDQCTLVAGGSDGVLQVYVGKRKP
The following text describes a protein:
Function:
Catalyzes the methylation of the lipid moiety of the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycoserosates to form phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDEIVFINWAYEEDPPMDLPLEASDEPNRAHINLYHRTATQVDLGGKQVLEVSCGHGGGASYLTRTLHPASYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESFDVVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPNNEIAAWEADLAATPLRQLSQRQINAEVLRGIGNNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYCFTKD
The following text describes a protein:
Function:
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
ETKSSEVFEPTSEWQTIKPGQAIPAGLHVQMNLQTGEKQAKLMDGDDGSKYKKHAKAKYYKEYNQKKEKVVKIDRNVFTKQHLKDALRDFKDKFHDDTTTGSGSEQIQTSRHFRPIEDIRKELEGSDIFMKKDIDVIKEHVQVLNSSESTMEQLEHALDELEYFVHQIDNAKDFDTIGGLAIVIKLMNSTESGLSSRAAYVLGSAVQSNPSTQKSAQSKGALLLLLRLLAPSQPMAVRRKAMYGLSSLIRLYSKGQQEFLKLNGLETFIKLFSEDKAGPLRVKALTLMTDILTEQFDYIKGKAKMQGVEELESVVKQVPLLQAMVAQGLCAHVSALLDTTDNDTREKVLQALDIMMVGCKHELKHTSVFKSLQRLRDEWTNSAASSQDSDERD
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MYLLIVFLPLLGSSVAGFFGRFLGSEGTAIMTTTCVSFSSILSLIAFYEVALGASACYLRIAPWISSEMFDASWGFFFDSLTVVMLIVVTFISSLVHLYSISYMSEDPHSPRFMCYLSIFTFFMLMLVTGDNFLQLFLGWEGVGLASYLLIHFWFTRLQADKAAIKAMLVNRVGDFGLALGIFGCFTLFQTVDFSTIFACASAPRNEWIFCNMRLNAITLICILLFIGAVGKSAQIGLHTWLPDAMEGPTPVSALIHAATMVTAGVFMIARCSPLFEYSPTALIVITFAGAMTSFLAATTGILQNDLKRVIAYSTCSQLGYMIFACGISNYSVSVFHLMNHAFFKALLFLSAGSVIHAMSDEQDMRKMGGLASSFPLTYAMMLMGSLSLIGFPFLTGFYSKDVILELAYTKYTISGNFAFWLGSVSVLFTSYYSFRLLFLTFLVPTNSFGRDRLRCHDAPIPMAIPLILLALGSLFVGYLAKDMMIGLGTNFWANSLFVLPKNEILAESEFAAPTIIKLIPILFSTLGAFLAYNVNLVADQFQRAFQTSTFCNRLYSFFNKRWFFDQVLNDFLVRSFLRFGYSVSFEALDKGAIEILGPYGISYTFRRLAERISQLQSGFVYHYAFAMLLGLTLFVTFFCMWDSLSSWVDSRLSFILLVSSFLINKSSQE
The following text describes a protein:
Function:
NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching.
Subcellular Localization:
Nucleus.
Sequence:
MTTFWSQTINRQNGGVATATATATATAATTTPTAGGTGAGTTTSTKGMITPTPFNIDINNDLNDFDGKFIETFKPDLELQKKYRSFIQREGALSFLRTEITQSMSKRDICVLILNLGYPKKAVEDYPILTLKELAYILLKLMLTDSAQLEPKVEIDENDNKNDGTNNSDIDSDIDSNSDMDSQSESGELDDAMDVDDSLSENEDEYDQDMSTTTLKRTINMTPFKYKLPDLISDLSRAKKIMVVTGAGISTSLGIPDFRSFKGLYNQLSKLNLSDPQKVFDLQTFMREPGLFYTIAHLVLPPDGKFSLLHAFLKLLQDKHKLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFAKAKCVSCQGIFAGEKIYNHIRRKQVPRCAICWKNTKQAPIHFGAIKPTITFFGEDLPERFHTLMDKDLQQIDLFLVIGTSLKVEPVASIIERVPYKVPKILINKDPIPNRGFNLQLLGLCDDVVSYLCKCLKWDIPHADFNNNDEFKLSKLKNGDWEIVKKSTSTKK
The following text describes a protein:
Function:
Substrate-recognition component of some (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKVR
The following text describes a protein:
Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps.
Sequence:
MTELTTPIYPLQRNWSWWFLNDDRNASWQDRLKKVYTFNTVPEFWAFYEAILPPSGLNDLCDYNVFRDDIQPKWEAPENWDGGRWLIIINKGKTPEVLDAVWLEILLALIGEQFGKDMESICGLVCNVRGQGSKISVWTKNCNDDDTNMRIGVVLKEKLMAAASKAHSKPLFDVIHYQTHRNCVKKTTSALKYKFSLKSIV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence.
Sequence:
MENTFTPLECLQPAGNLKYCLIILNQPLDKSLLIHLWETAIFKACADGGANRLYQAMEGSQDRYLPDFISGDFDSIKPEIKTFYKEQGCELIQTPDQDFTDFTKCLKILQDKIRQSNAEMDVIVVLGGLGGRFDQIMASVETLYHAVTPLPVIIMQDTSLICLLKPGKHILHVATGKEAKWCGLIPVGSACNSVTTTGLKWNLSAGVLKFGTLVSTSNSYDGTGVVTVETDNPLVWTMGIKKMNDH
The following text describes a protein:
Function:
General inhibitor of family S1 serine proteases.
Subcellular Localization:
Periplasm.
Sequence:
MKLPQLCHLAAVPLAFTLLSFNASAVSPPHPTGLDAPMISVSSMNANNYAPVETVKMFPAPKKGMVQHILTLPKLENETDYMVEIQIGQTQLVDCNKHGLNGQLKELTVEGWGYNYYQVDEISEGPSTMMACFELAKKEAFVQIPDELTLRYDSRLPKVFYLPEGAELRFRTWKADSTYQYSK
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.
Sequence:
MEWVLADALLSQSRDPRVLLGALCRGEASAERVETLCFLLQRLEDEEARGGGGGAGALPEAAREVAAGYLVPLLRGLRGCPAGGADDPGPAARQRRRVLRAAGAALRSCARLAGGPQLAAALAEEALCDLLNAGPAPGLEGAAEAAVEVLVAVGSCLRPREDAPLLERVARAALALALGGDKAGPSPDAAALVAGRLLPALGRCGGAALRAVWGGLVAPGVSEGPGRVGSQLLILSALAEKLLPEPGADSVPASREAGLDARRCWRFWSTVQAGLAWSEDALTRKRARYLLQRAVEVSAELGTDCACAPGEGTGPSLFWWSEKKKDELLKFWENYILIMETLEGNQIHVIKPVLPKLNGLFEYAVSEENGCWLFHPSWHLCIYKRMFESENKILTKEGVTHFLELYETRILPFSPEISEFIIGPLMDALSESSLYSRSPGQLIGSVSPLGLKLQKFLVTYISFLPEEIKSSFLLKFIQKMTSRHWCAVPILFLSKALANVPRCKALGMEGLLALRDVLQCTMITHQILLRGAAQCYLLQTAMNLVDVEKVSLSDISTFLMSVRQEESLGRGTSLWMELCDWLRINESYFKQSSSCSSTGLHETSSLNAYVRNLVQEYIRSSAWEGGENSCMPDWFEAKLVALMVLLAIDVERMKSQYSEKRRTQNVLRIFLDPLLDALVKFGTNAYMPLLKTDRCLQLLLKLLHTCLLKGSGTQDDEVFTLLQNFIMSTTESISEFILRRLTMNELSTVSDLDRCHLYLMVLTELINLHLNVGWKRGNPIWKVISPLKNASIRHLQEMDRGQEPTLGRQIQRAVSMAALAMVCEVSQKPELQLDSLDVGPPETFISSLQLNQTLQKPHTEEESSFFEESSSSQGWGKIAAQYIHDQWVCLSFLLRKCHTLIPASEGEILEPTLPAVPMAVRTLQSALEALTVLPSEQVLPVFHCMKILVPKLLTTSESLCIESFDMAWKIIASLSNTQLIFWSNFKAFVQFVFDPKVLTIAAKIKGQAYFKIKEVMYRIIEMSAIKTGVFNILISYCCRSWVVSASNVSLSIAKNYSELVLEACIFGTVFRRDQRLIQDVQTFIENLGHECAANVVIENTKREDHYVRICAVKFLCLLDGSNMSHKLFMEDLAIKLLDKDELVSKSRTRYYVNSQQHRVKNRIWQILLVLFPKFDQNFLNKIIDKIFQAGFINNQASIKYFIEWIIILILHKFPQFLPKFWNCFSYGEENLKTSICTFLSVLSHLDVITETILEKKLILKQALTIVLQWCFNHNFSIRLYALVALKKIWSMCKGLHIEELAALTSVIESSLSQVENMHGAGSAKKNWQRIQEHFFFTAFHPLKDYCLETIFYTLPRLSGLTEDEWIAIGKFTRFTDIPLGAGFQWYLSTTHLCELKPGDWSQQDAGSNSGEADNQSEWTDVQKKIIPWKNHVPDFDLELVFQDRAAKLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGAAALVMGSLQCVRDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKAEGYTIVGVEQTAKSLDLTRYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHGIFPTQGSNPGLQHCRWILYQLSHKGSPPRRDKKKDVDQRRA
The following text describes a protein:
Function:
Monocarboxylate-proton symporter that mediates the efflux of the waste product lactate in the intraerythrocytic parasites; active in acidic-to-neutral pH range. Transports L-lactate. Transports D-lactate, pyruvate, acetate and formate. Essential for asexual growth but dispensable for the development of gametocytes.
Miscellaneous:
MISCELLANEOUS: The expression levels parallel that of the L-lactate dehydrogenase and the glycolytic enzymes. In contrast to human monocarboxylate transporters, is not sensitive to p-chloromercuribenzene sulfonate (pCMBS). BH267.meta inhibitor attacks parasites at the trophozoite stage. Inhibition of the protein leads to a build-up of lactate and swelling of the parasite and infected erythrocyte.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MPPNNSKYVLDPVSIKSVCGGEESYIRCVEYGKKKAHYSNLNLLAKAILAGMFVGLCAHASGIAGGLFYYHKLREIVGASMSVFVYGFTFPIAFMCIICTGSDLFTGNTLAVTMALYEKKVKLLDYLRVMTISLFGNYVGAVSFAFFVSYLSGAFTNVHAVEKNHFFQFLNDIAEKKVHHTFVECVSLAVGCNIFVCLAVYFVLTLKDGAGYVFSVFFAVYAFAIAGYEHIIANIYTLNIALMVNTKITVYQAYIKNLLPTLLGNYIAGAIVLGLPLYFIYKEHYYNFERSKRDNNDAQMKSLSIELRN
The following text describes a protein:
Function:
Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42.
Subcellular Localization:
Cell junction, focal adhesion. Cell membrane; Single-pass type I membrane protein.
Sequence:
MDTWLILVWLSGVLTCLSASNVTTVSSSAGVSALPSSARATTVAAPDQEEVTRSTEGASPSPPISLRPGTPTLGPGATPPPTHGATFSPSAPVNSTATTGPTGPTSPSPNATPLPEGDSSGTWAEPWEANSSTGATSTSGAFTTPGDTDSTERRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTDDMEPQSVPLLARSPSTNRKYPPLPVDRLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDVTNKKPQRLVTQFHFTSWPDFGVPFTPIGMLKFLKKVKTCNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMATEKKVDVYGFVGRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLESHLQKIYTRVPGTSSNGLEEEFKKLTSIKIQNEKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLQHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPCDNPMACGDITMELKKEDECESYTVRDLLVTNTRENKSRQVRQFHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLVGAPRLSGLPPGRQERARSQVRGIEPPPPPTPSGWGAGAGAPGGNSHRDGTPGHRQKRSVSWLAGGSTGTEPTKITWGAGEGLAGSRASSLGRGRTLTAERS