lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol (1,2-PD) to propionaldehyde. Required for S.typhimurium growth on 1,2-PD as the sole carbon and energy source (Probable). This subunit is directly targeted to the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation, and is also responsible for targeting the other 2 subunits (pduC and pduE); The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Miscellaneous:
MISCELLANEOUS: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate. BMCs can constitute up to 10% of total cell protein.
Subcellular Localization:
Bacterial microcompartment. Note=Probably located inside the BMC shell.
Domain:
The first 18 residues targets this enzyme and foreign proteins (tested with GST and eGFP) to the BMC. The cargo is only detected by Western blot in broken shells, strongly suggesting this protein is normally found inside the BMC and not on its exterior. PduD and PduP compete for encapsulation in BMCs, suggesting PduD also binds to PduA and/or PduJ.
Sequence:
MEINEKLLRQIIEDVLRDMKGSDKPVSFNAPAASTAPQTAAPAGDGFLTEVGEARQGTQQDEVIIAVGPAFGLAQTVNIVGLPHKSILREVIAGIEEEGIKARVIRCFKSSDVAFVAVEGNRLSGSGISIGIQSKGTTVIHQQGLPPLSNLELFPQAPLLTLETYRQIGKNAARYAKRESPQPVPTLNDQMARPKYQAKSAILHIKETKYVVTGKNPQELRVAL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MRPNIMSSLETFQSQLGSVMERLAGAAVAELGRLLKQSSADVWTGPAAAPAPAAGSEESRREDESFRQSFQKITDRFASLMEVWTKDAVESILKMLKASKCQVSLAEQSKGLNMRRKRRSRTVQERVSSRRTAAVSAQTDCGSTSAAETTPPDSGEGETVPEDSEVTGQEKRAVGRFQCPTCDKTFALKCLMNRHFLIHSRPHLCSQCGKRFAALRGLTAHSRTHTGQKLHRCAQCGTGFAHKSSFQRHMQKHAVEKARMHTCPACQLEFWGERAFQRHRCCALKKTFECSVCPETFECRQTLANHENLHSGARDFVCEACGERFLSAASLAVHRVIHVQNEDGPLNKEGGEKAFTCDVCGKGCSHRSALKHHMLTHSGERPYVCETCGKRCSHASALQNHLRIHTGRKAGQKPTCRVCRKEFSSAVKLKYHMSVHTGEKPYACDQCDKQFSNPSNLHVHRRIHAGEKKYGCNVCGKSFIQRISLKLHTRVHTGETPFHCSTCGKDFTHRCDFRKHQRRHLAEDEGRDKAAAAVSALC
The following text describes a protein:
Function:
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.
Domain:
The DAZ domain mediates the interaction with DAZAP1 and DAZAP2.
Sequence:
MSAANPETPNSTISREASTQSSSAAASQGYVLPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPPTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNTVVTQDDYFKDKRVHHFRRSRAMLKSV
The following text describes a protein:
Function:
Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MWRWSTGVRTMLGYAMCFLALGSALTVRLHSTRTNLPQYLTREIGDDEFEELLRSSASAGHKWHVEQFVDGSRCYVPETEQNMAPVPDDLLERGIKLVEEATVGKKLEYLPISYWGYKFINSELNKTVIQHKDQHQVLLGSMVKADPQTVQHSLERDEDSYYISERFGDGDLCSLLEEDRTVEVQYRCKYDTPLEIILDLKEYETCRYTMLVSIPSLCELPEFGPYTRQTPANTIYCTAPATPEFNIATLVEAYKPTFLGHGFYHLAPHANLTHKETTAMLMYHQQPIPGNEEDDGTMDSAFIKHSTMAYMQLLEMGLLNGPDGLPFSEEGNFTVYAKVIGFDGGLITVTRFQISHGEVIIDHVVPEVLEDMEQGNSEDYEQQAPEQLDEEEAELTSQSDDPAIMRVHLQEFITPEYDAIE
The following text describes a protein:
Function:
Involved in biosynthesis of the epicuticular wax. Plays a role in very-long-chain fatty acid (VLCFA) biosynthesis and is required for C30 fatty acid elongation in leaf. Despite its classification as a BAHD acyltransferase based on sequence homology, CER26 does not seem to share the catalytic mechanism of the members of the BAHD family.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGRSQEQGQGQGPVHSIRLSTVGATRPTETGTTHEPTGLDLAMKLHYLKAAYIYSAETARDLTVRHLKEAMFMLFDQIAWTTGRFSRRDSGRPYIKCNDCGTRFVEGQCNLTVEEWLSKPDRSVDEFLVYHHPIGPELTFSPLIYVQMTRFKCGGLGLGLSWANIIGDAFSLFYAFNLWAKAITGEKIYAPTTPSIGERRFQSPNPTVKDPVSIKRVEPVGDLWVTPNDKKLANYCFNLSVADQISPHFPAKGDDSIPVFEILAGIIWKCIAKVRVEPKPVTVTIIKKDPNDLKLNAIRNSQVISSVSVDFPVAEATVEELVKAMGEAKDERCGIEEIGESCDGNLDFVVYGAKLTFLDLTGEDLYEAKVMGKSPESVYCNVEGIGEEGLVVVYAAAKSEERVVTVTLPEEEMERVKLEFKKFGLIAP
The following text describes a protein:
Function:
Calcium-permeable, cation-selective stretch-activated channel (SAC) that functions together with CCH1 to mediate calcium entry into cells. May additionally play a role in cellular detoxification of radicals.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPAREVYLKRPATRRQLEGICTRYDGQQRITQLDCEEGCSKRTQPPQRLNPRYKSPDLIHISFIIVLLCILSMTSSVVAQTTTGSSSSKAAATPILPRQTLPTTISLPPLNISHPVLQLALPPTSSLYLTFSICSLTSNATILPTVLISTSSPASFNLGSKPIRDASTGGIPTSSGGKGYNYKSGRNGATWGLKWSSGFGNWTLNGTSETQVHLLLGLGLGNDGSTLNTTGVGNGNVVVQMGASTSGPLHALSAVYPLLGDTTSTSALIFSPLLYSSPQPEPSYPNYTLPGAQLAFPDFSYSEPLNSSLSSNLTLIVVPTNASPTSTDLGNSICAINAASANSSVSGANNTILKSFQPEWMTVGDEQGFRSYWVLGDLAEQGNYTAWVSDDKGVLSQPAWFATKPAGFPCQLVMPNDVCPNLGYSAPLDANSTAVTSPSGATISPTSPIQTLPDDLLELIVQNLEAFSTSLLSHACGRDLFSHVSSCLDCYSAYRDWLCRIVVPQCGAANSTSGATVIETATSTSTSSGTFPTPSTVLRTPSSPRNPSLPIPAYSYYELLPCMSTCNRADRSCPVSMGIRCPKRKVNAAKSYAFVGDDHSYGDGSAAQGVAAQDRWGNRWCNG
The following text describes a protein:
Function:
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSTRLSSRGFTLIEVLVALAIVAIALAAAIRAVGLMTDGNGLLRDKSLALLAAESRLAELRLGVGAAPGNSDFECSQGRLRLYCEQRVEATDDPALLWVEIRVRTQREQAVPLARLNTLLSRSR
The following text describes a protein:
Function:
Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits ADP-induced platelet aggregation in human platelet-rich plasma.
Subcellular Localization:
Secreted.
Sequence:
MIQVLLVTLCLAVFPYQGSSIILESGNVNDYEVVYPRKVTALPKGAIQPKNPCCDAATCKLTPGSQCAEGLCCDQCKFIKAGKICRRARGDNPDYRCTGQSGDCPRKHFYA
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MARPQQRFRGVRQRHWGSWVSEIRHPLLKTRIWLGTFETAEDAARAYDEAARLMCGPRARTNFPYNPNAIPTSSSKLLSATLTAKLHKCYMASLQMTKQTQTQTQTQTARSQSADSDGVTANESHLNRGVTETTEIKWEDGNANMQQNFRPLEEDHIEQMIEELLHYGSIELCSVLPTQTL
The following text describes a protein:
Function:
Small heat shock protein required for the establishment of auxin gradients and for patterning of the apical domain of the embryo. Involved in the specification of the cotyledon primordia. Also required for normal inflorescence and floral meristem function, normal developmental patterning and thermotolerance. Acts as a molecular chaperone.
Subcellular Localization:
Cytoplasmic granule.
Sequence:
MEVDDGNESKPSASPVAFSSVFDPSNRIGFFKSAFAFASQMAADIFDDNQEDKMENKILSLLDDIKKRKREKKDESEEEEDAENKRLRTLEADTKKPSHDDPSPPNKNNGLDMKNYSWSQTLGDVMVQVPVPFGTKKKVVICDIKNTSLRVGVKGQPLLIDGELFQAVKVCESYWILEDNETVTILLSKCNPWEWWKSVVKGDRGIETSRCEPGLRRLDGLGYEAERHMRKLLFDYGQKCKGLPTSDNCPEVLQKFIVHHPYLNLPQSK
The following text describes a protein:
Function:
Photoreceptor implicated in non-image-forming responses to light.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDVDQGFYRHVDVPDHVHYIIAFFVLVIGTVGVTGNALVMYAFSCNKKLRTPPNFFIMNLAVSDFLMAITQSPIFFINCLYKGWIFGETGCKMYAFCGALFGISSMINLLAISIDRYIVITKPLQSIAWTSARRTCFIIALVWLYSLFWSLAPLLGWSSYIPEGLMTSCTWDYVTATPSNKSYTLMLCCFVFFIPLGIISYCYLCMFLAIRHTSRDVTQLGSQVRKSTLIQQQSIRTEWKLAKIAFVVIIVFVLSWSPYACVTLIAWAGYASILNPYSKAVPAVIAKASAIYNPFIYAITHSKYRETLAEKVPCLHFLAPSPKRNCISMSHSRSSVRDSMLSRQSSVSTKKFQRVSSLSTTETVWSDVELDPIEQMDSLKSSYSLQALSENDCKSLTKEAREKGSQSL
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as a metal chelator of copper (Cu) and zinc (Zn). Plays a role in storing and distributing Zn ion in seed.
Miscellaneous:
MISCELLANEOUS: Plants silencing both MT4A and MT4B have reduced seed weight and reduced seedling growth after germination.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane.
Sequence:
MADTGKGSASASCNDRCGCPSPCPGGESCRCKMMSEASGGDQEHNTCPCGEHCGCNPCNCPKTQTQTSAKGCTCGEGCTCATCAA
The following text describes a protein:
Function:
Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity).
Domain:
Atypical domain architecture: contains 2 histidine kinase/receiver domain modules.
Sequence:
MQDISTTTASTNYLKADGDTGAVFSITSQQQQIHYMRKQKPDHEKTREELIEEINHLRAVSNSNKNARIMLDEMYQFVALLDVNGNLLDVNEPALQGGGMIRSSIQGIPFWDCRWWATSQENIDNVREAVHKASKGEFIRYETEIFGKSAGTEKITIDFSLMPLFNDKGEVSLILPEGRNITEKRLGELEIERKNNELRSLYEKIKELDELKTQFFANVSHELRTPLALIVGPTDKLLKDENVDINVRKDLEIVARNARGLLKIVNNLLDISRLEAGKMNLNYSMVNLGQTVHLIASCFEILAREKSLDFSIITPSEPMMAAIDADKMQRVITNLISNAFKFTPSGGAVKCILEKFDLSPNKPGFQIVVSDTGPGIPDNLHEIIFERFRQVDGSSTRKHGGTGLGLSIVKEFVTLHGGTVTIHNISTGGAQFTLRLPLTPNMDEHLYKKTISDQNISEIQQQLYQQQQQEQQQQQQQQQNLQQPKLILNNIDNKYKINDDDNDDDDDDDDEDGLNFNILKKTNTSSDIASNALKDNMGSIMGVHAIAQQAVEELTEKQFYQSQENIHNKPIVLVVEDNPEMNRFIAELLSKYYFVVTAFDGVEGIEKTRAITPDLIVTDCMMPRMSGDEMVEQLRSDEQFDNIPILLLTAKADENLRIKLLQNGVSDYVNKPFSSEELVARVVNLMTMKKAKQFLQEELSSANTDLQELINQLTNKKRDLQTLVGELEKERNLLNNTNKSKDEFFMNLSHELRTPLNGILGWCQLLLYDIDSGGSSGGGSGSISGDDSTVRTGLETIERCASSQNQLINDLLDMSLIIGDKFSLILGDVDLPILIENAISSILVTAQSKKISVHSNIQGEGEEESSILRNIVGDKARLQQVIWNLLSNSIKFTKEKGRIHLNLKVVNQIPSREVLGFCSNPMFNTINRHGDRWILFTITDNGKGIPKQFLPSVFDRFKQADCSSTRSYGGLGIGLSITQNIIHLHKGAVYANSEGENKGSQFTVVLPIIKGSSSSNSSPSNQLSCSSSPPLIKKPFFSQPTNYINNNNNNNNNNNNNNNNNNNNNNNNNNNNNYNNYNNNNSNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNLNINNLINNNHNNNNNNYHHNNNNNNNSNNNEKLGKRQREEINNNENNNVDLRLRTPPPPPTSSISENFLVNSSNLIPSPALNPINNNNNSNNNNNNIGDIKKINLEISQIPSTNLNPKLSLVINNNNNNNNNNNSLLKTIITNAINNNINNSNNDDNSNNTTIPTPPSSAINMINSLPLPSPSPSFILPTLSPFSSPLSELKSSSNNNNNNNNNSNNNNNNSMSPNLRSPKANSNKNLLGGIQIMLVDDLEETTHLFSSMLYKLGAKRIDTFQRVSDAYAFLCDSSKPQPDIILSDLTMPFEDGYSMVRKLRDREKINTQNKKTPIIALTASVSSSDKEKVLKSGFDLHCSKPVNFLELSNSILTLIEKYNTTVNIDLIKEQEQNNNNNNNNNNNNNNNNNNNNNNINNGNDDDSLLLTDSRPCKKANSQ
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSNQVFQFPPYYHKEPFFTIQPILNTRKKQFQMWQDLILQYCRYYKIYELDINESIKSNSVLFNNEKINRKLSREALKSIIDDIIENGFAEWVDKEKEKEKEKDKDNNNNNRVLIMWRKPDEWASLIYKWVADCGLLNTVLTVWEIQNGDDSKKQEFHQLNTTILMKSLKVLEKQSKCQTFSQDENVGVKFFSI
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MPPPDPAAMGPGEVASRSPLDKPFADLTDEDIAQLTREDCRRFLKAKGMRRPSWNKSQAIQQVISLKALFEGRPGCDDSPAGGGILRKLPPVTSAPVSPPQNSPPPATEEGSGGGGSGAQPPAKEPSPYRRKDPFPPPFFAGDLTCSTPIAEPDSPHPPENRCFSPRTTADLPGEQMTIFYDGMINVYDDVSADQARAIMELAASPACFEDPTDPLPPARRPVFRLPPGPAPPFSRAFRIRATGRMPHRVAGGLEGRRVPRETEHEVPTSRKASLQRYLEKRKDRFKGKKILGGSTSSDMEMMYISQKLRCLNHSELPNLNETSFPSLSQPPQSPARCSSAENQSGDKYFIDLNDDSGGI
The following text describes a protein:
Function:
Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA). PuuE is important for utilization of putrescine as the sole nitrogen or carbon source.
Sequence:
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEVQSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLCERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAVEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALSD
The following text describes a protein:
Function:
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
Sequence:
MQTLMSHSHSRVAPLPGAITKEEIKNQLMVHERRFLSKPTRKEEWTVLPQSAHSKNTVNPVRRIADACAVPPNPEKKVIRLHLGDPSVGGKLPPSEVAVQAMHESVSTHMYDGYGPAVGALAARQAIVDRYSSSDNVFTADDVVLASGCSHALQMAIEAVANAGDNILVPHPGFPLYSTLCRPHNIVDKPYKIDMTGEDVKIDLSYMATIIDENTRAIIVNNPGNPTGGVFTKEHLKEILEFANKYKLIIIADEIYGDLVYNGATFYPMASLSPKVPIITCDGIAKRWMVPGWRLGWLIIHNHFGVLNEVKQGIVALSQKIVGPCSLVQGALPKILRETPEEYFVYTRNVIETNANIVGNILADVPGMRVVKPKGAMYMMVNISRSAYGNDVNFCQNLIQEESVFCLPGQAFSAPGYFRVVLTSSTDDMEEAATRIRDFCFRNINQFSDSEDSSDEGLDLSAMESD
The following text describes a protein:
Function:
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Sequence:
MMLGMRELQEQFDIKKKIGSGSYGDVFKVRVRQTDQIAALKVIKIQEDDDLAIIEQEIQILRGCVHPNIVQYFHSEFRRQQLWITMEYCGGGSLQDIYKRTGALTEQQIAFVCRESLRGLDYLHQQQKLHRDIKGANILLTEDGDIKLADFGVAAQITNTFQKRQTFIGTPYWMAPEVANVEREGGYDQACDIWAVGITAIELAQLKPPLYEIHPMKALLIIGKSDYKPPKLKEKNLWTVKFHDFIKETLTKDYTRRPSAGKLLQHHFAAQPLSKESTRALLHAYHAKLQLKKKHKEMKRVKSVKHPKEEYKVPVRQPEKVEIPKPSRPAPSPSNHAVNPTPAIPNKPPKLPPKHAAISAGPSGTLVGESGEKPPIPPRAPTQRRSVLPSSMHPENRRLKINIKTLFCGCPMHIYDVAFWCRNEEDKCILIGTDEGVFLMSTNENEPTHQQFFQIIRKKTVWLAVHKDTLSALSGNDSSSLMLRFYNLNRLYERVEFSANILSNLPFLDNGNKVTDTKGCKRCTMITHPFHKDRTYLCAQLPESILLMQYDEHQNTFKEIERFPFNFPGDLPLFELFADQEHDYPFLCIGVKLRLRKINAFNAFDKGQTRFYNLDGTLKSSNNMPSVLNFSGNPLFVVEDCQVQVIIGILENGIEIKQFHGGRGDHDQIVPSGGKKFRFLGSNSARVFIAEIEGHNEYDLYEIVVKVLLPSHLLIVRFLLITSITENDDI
The following text describes a protein:
Function:
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MMLSLGWIFLWLVTGEKIKGMTTSDCLTKKLLWEYSSRSEEFVLFCDLTELQKSHLHHRSQLLPTQSSENLPCSGHEDLSDVQWYLQTQNGDSLGEITNNFPHITQDKSNLCFLTAGISNAGSYICRPRIRTPQDEACCIKTILEVKPKTNLSCIPNNSVSQQYLLFGSIAKINCPSLNCQSDAQSPEVTWYQNGKLLPKERSNPIVVNEVYETNQGTYVCDYTQSDNTSSWIVRAVVQVRTIVKDTTLKPDILDPIKDVLEVELGKPLTLNCRARFGHQRDFNPVVKWYVKDSDQESEVPTPETIRVKHTIKDEVYERVIHLKEVTQRDLRKKFICFAQNSIGNTTQSIQLKEKKGVVFIYILLGTVMTLAGMLTAGALLYMYWIEIVLLYRTYQSKDETLGDKKVFDAFISYAKWSSFENEATSSLSEEYLALNLFPEVLENKYGYNLCLLDRDVAPGGVYAEDIVNIIKKSRRGIFILSPNYVNGPSIFELQAAVNLALDDKTLKLILIKFCSFQEPESLPHLVKKALRVLPTVTWRNLKSVPPNSRFWTQMRYHMPVKSSKGLRWNHLGSISKVFHWK
The following text describes a protein:
Function:
Efflux system for nickel and cobalt.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHTHSHELTLGLAFFLGALHALEPGHGKTAMLVYLSGERRSFWHPIVMGISSGLAHSVSLIAIAMAVHLTHHLVSGAHHHDDEVVTQSLQWISAALVMCVGVWMLWSAWRAKPMACGCKSHQHTSCDAEPVSKRSSYSMSALLGVAFGLLPCPSALAAYFTSMSTGSPVAAYAVIGLFAAGIASSLTLVGILLQRFGGSLIRKDSRIGKLPWPYLRAGLILAVGVFYCSRLALTA
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Essential for peroxisome biogenesis.
Sequence:
MAARLMKEYKVLQNEEFEDILLYPRDESDLYRWVAIIKGPPDTPYENGKFELDISVPTNYPLQPPTIKFVTKIFHPNIHFKTGEICLDLLKTSWSAIYTLQSVCRSIIALLSLPEADSPLNCDAGNLIRNGDVKGHDSLARMYTRLYGC
The following text describes a protein:
Function:
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.
Subcellular Localization:
Nucleus.
Sequence:
MAVTSATAEQKASPALFEIYGKIWNVQARLGQGVSASVYRVSSGRATSAVKEFQVDPQGGDYGYLKESSVLEKIQGHKNIVTLYGMFTNHNPFGVATHCLLLELLDVSVSELLVRASNQGHSMWLIQHCARDVLEALTFLHREGFVHADLKPRNVLWSADDECFKLIDFGLSFKEGHQDVKYIQTDGYRAPEAELQNSLAQAGVESDSGCTTAVDLWSLGIVLLEMYSGMKLKETVKSQEWKDNSSAIVDHIFSSNALVYPAIPVFHLRDLIKSMLHNDPKLRSTAKAALMSPFFSIPFAPHIEDLVLLPTPVLRLLNVIDDSHLYNEDEYEDIIEDMKEECQKYGTVVSLLIPKENPGKGQVFVEYANAGDSKEAQRLLTGRTFDGKFVVATFYPLGAYKRGYLYQTVQ
The following text describes a protein:
Function:
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere.
Sequence:
MATSELSCQVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDAERRETYHQQGQCQALVQRSPWLVMRMGILGRGLQEYQLPYQRVLPLPIFTPAKVGAAKEEREETPIQLRELLALETALGGQCLDRQDVAGMPGSPEFPRGREQRQRALRVESWGPAQPSTPSPRREDKRYG
The following text describes a protein:
Function:
Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MQNLLWIVPLSGFIGFITAYFIARGILREEEGPEEIKKIMKAIQQGADAFLNREIRTVSIFVILFGIFMAIVLQPLLGLSFVIGASFSMLTGYIGMKIATRANGRTTYAAAKYGTGRALDIAFSGGSVMGLMEASLGIFGSSLIYLILSRFMPDPRLKLEIISGYALGASFIALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDVAGMGADLYESYVGAIHAGAVLGFAYADLKGLLFPFLLAVIGLYASIIGIIFTKVYASRKNADPASALRNGTFLSAGITIVGSYFLSLSLVGNSGPFWASLIGILAGIGIGLISEYYTSNKPIERIAYASTTGPATNIITGLSVGMESTFLTIVILAIGTYLSYIANGMWGVAIAGVGMLATLGITLSVDAYGPIADNASGIAEMAHQGERVREITSSLDAYGNTTAAMGKGFAIGSAILTALSLFAAFKEWAGISYIDISKASVLAGALIGGMLPFLFSSLALKAVGEAATHMVEEVRRQFREIKGLLEGKAEPDYARCVDISTKGALKAMVLPSLIMILSPFVIAFIFGKEALGGMLTGATISGGLLAIFMANAGGAWDNAKKLIEHGKFGGKGSDAHKAAVVGDTVGDPFKDTAGPSINILIKLMSVISLVFLPIFFH
The following text describes a protein:
Function:
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGSKIVQVFLMLALFATSALAQAPAPTPTATPPPATPPPVATPPPVATPPPAATPAPATPPPAATPAPATTPPSVAPSPADVPTASPPAPEGPTVSPSSAPGPSDASPAPSAAFSNKAFFAGTAFAAIMYAAVLA
The following text describes a protein:
Function:
Involved in the assembly of chloroplastic iron-sulfur proteins. Is able to transfer iron-sulfur clusters to apo-ferredoxin.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MAFATGITTSSNPTFLGLKISNTSLRSVVSCNSISFPSLSYVNLNLNRRNRLSVRSASVPAAPAMEGLKPAISLSENALKHLSKMRSERGEDLCLRIGVKQGGCSGMSYTMDFENRANARPDDSTIEYQGFTIVCDPKSMLFLFGMQLDYSDALIGGGFSFSNPNATQTCGCGKSFAAEM
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVGGLFMAEHPRMPGCDSCDRQPPQLPNLRRAGTPVLLCALGSAGGACSSPSLTPKFPQISAPKWVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNTYGKSLSNSKH
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MERPVQMAQEWLEGLGADQSGSAYDPAKPKRNEFERFSLAGLRVSRAEPGRIICHLTVPKRLADEKGKWHAGAIAAMIDNVGAASIKSCDLPIKVSVDYNISYISTAEIGEVMEIEGKVLGHKGKLSGVMVEVRRKGNGEVVAQGRQWMKATSRL
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDKDDDVDTKKQKTDEDD
The following text describes a protein:
Function:
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSSQYRKKNATGKTIVTKNSTKTLIEEAMNMRGMKDDSFDIADSTDWLGTPLSQLADVDSLLRCQVCKDFFTTPMITSCSHTFCSLCIRRCLNNDSKCPTCRSNDQEIKLKPNAAIEDLVEAFKRARPAALELARRPAVEITVTSPKRKREISDLGGLDEQGVNKKTRASSRQAARRLESAEAAKASKDVIVVDDGETDADLIPDDGLTACPVCNRRMTAKSVEAHIGRCLAESEAPAQSTTILSKPSFSSPGPVKRPERLPVVNFSLIKDQALKKKLIDLGISAAGGREMMRKRLTEYTTIWNANCDAKYPRGTAQLKKDLDSWERTLGSRAPQLSALSAHIKDKDFDGLAWGEEHKSSFNELIAKAREKIKNKSPEMAEGNSSTFTTTPLIHSQTSQGLAPSENFVKEQKDPMKESQGDRANIEINPAPLPHTLPKGLEASNPPFPGRFFAANVEQIPDHTMAAIPPSRHEKELPYNADARSTE
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Subcellular Localization:
Cytoplasm. Mitochondrion matrix.
Sequence:
MAVFRSGLLVLTTPLASLAPRLAPILTSAARLVNDTLYVHLQPGMSLEGPAQPQSSPVQATFEVLDFITHLYAGAKVHRHLDVRILLTNVRTKSAFLPPLPSSVQNLAHPPEVVLTDFQTLDGSQYNPVKQQLERYATSCYSCCPQLASVLLYPDYGSGELPVEPLDVPLPSTIRPASPVARSPKQPVRGYHRGAVGGTFDRLHNAHKVLLSVACILAQEQLVVGVADKDLLKSKLLPELLQPYAERVAHLSEFLVDIKPSLTFDIIPLLDPYGPAGSDPSLEFLVVSEETYRGGMAVNRFRLENGLEELALYQIQLLKDPSHKENEEDKVSSSSFRQRMLGNLLRPPYKRPELPAHLYVIGLTGISGSGKSSIAQRLKGLGAFVIDSDHLGHRAYAPGGPAYQPVVEAFGTDILHKDGIINRKVLGSRVFGNKKQLKKLTDIVWPVIAKLAREEMDQAVAEGKHVCVIDAAMLLEAGWQNMVHEVWTVVIPETEAIRRIVERDGLSESAAQSRLQSQMSGQQLVDQSHVVLSTLWEPHVTQLQVEKAWDLLQKRIPKIHQAHE
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MATAPTVHIIGFGSIGGLIGVHLQCAGIARVVPVLSSPARAALFHELGSKATLDSVHCPETPPLSAYFPAAVSTSDLQETGSPIDHLVITCKAQHTLAALRPVWPLLHNGSTIALLQNGLGVAELLRAEASRRGLSPTLFQGVVTHGAHRDSHWNLHHAGKGQLLLACLPRDPTSIIQAPATVARARASPLAAALLRTPLDAALLPYQQLLPRQLEKLVVNACINPLSALLDCPNGALVPQRELFAAIAAEAAPVLRSAYSALFSSTTGPPPADPDLLAPERLSEKAAAVAVATASNSSSTREDVRAGRTTEIDFINGYIVDLAAAAGLPASAVRLNRALQLLVHALRR
The following text describes a protein:
Function:
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Sequence:
MSGSNAMTLLKNRMQSMKDEAEKFKDMYEEKCRDLEEEKNKKEARRLRLLEDENEMNSTKWQETQSKLNSLNHIADEHDRTKRVFDNQQNILEDRLNELEMKLKECKESEREAESKYTEASRKTSILEAELEKAEERAETAERKWKQMESDLIATSTHLKSLQFSEGELSQKEETYERTIKELASKLKDSELLASELERHSAKLQREVDRLEEELEKSKDVNKKLEAEMENCINELQSM