lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAPPFVFPSTLRDLERDDDGDDEGEPSLRPHAPIAVTALRAADLDEFVKGTSFDLSDKELFCIEEQDVFNNIYSLVRDFTFLPPALKFNLVEALRSNLSVLLPNIHSLSRASMSSPSDGIPIADRIASHRNALKIYSFFLLSIVLAQESSADSGTGAKVAAHGRKKNPVYAWNWEAQRGRIMNLVANSLEADLTLLFGPGGADERYLSFASKCTYVLFENQNVLKDEETRNGLCRIIGAVATRHQKISQTSASVLHLIHKYDFTVAHLAEAVAAAEKKFGDGSLAISLIREVGRTDPKDYVRDAAGADNVGRFLVELADRLPKLMSTNVGVLIPHFGGESYKIRNSLVGVLGKLAAKAFKDVDGNNSAHSIRLRSKQAMLEILMERCRDVSAYTRSRVLQVWAELCEENAISIGLWNEVASVASGRLEDKSAIVRKSALQFLITMLQHNPFGPQLRATTFEATLEKYKEKLEEKESQSPVEGELADDHPLGEVIVGQDESVSDSCLPSSQDQTDKDPTFVDITNLEQMRAVYASLEAGLRFTTCITSLMPILIQLLASSSATDVENTILLLMRCRQFQVEGSEAALRKMLPLVFSQDKSIYEAVESAFIAIYTKRTPTETAKSLINLNIDCSIGDLAALENLVSSLVLKGEISSNMMSALWDYFCFNINGVKPVQCRGALSILCMAAKSSPSILGAHLQDIVDIGFGRLAKEEPLLARTACLALQRLSEEDKIKLLSTSTRVFAALQSLVTSFSLPDKIWYGATDKAISAIYTLHPAPEIFAAEIAKKSLSSVFGALGTDGVSNGVELETQNSSIITEISTMKLGRFLFVISHIALNHLVYIETSVKKIHKQKQKNEKSQSTNEDSPVDGSKKSEAQDINAELGLGVTRDVAIEFFAEKAEREIVSYSCEKNLIGHCGPFLSKLCRNLTLLQKFPELHASAMLALCRLMIIDTEFCEANLQILFTVVENASSEIVRSNCTIALGDLAVRFPNLLEPWTEHIYARLSDSSASVRKNAVLVISHLILNDMMKVKGYINEMAVRVEDEDERISSLAKLFFHELSKKGSNPIYNLLPDILSRLCNQHLKEETFRNIMQFLIGSIKKDKQMEALVDKLCNRFAGVNDVRQWEYISYCLSQLTFTEKGLKKLIDNFKMFEHALCEDSVLNHFRSVIAKCKKFAKPDIKACIEEFEEKVSKVHEEKKEQEATARNAEAHKQKIDSLDKILLAKEVGQDDKNSAEEETSEVIDPSVDGNAEDKEAEETSEVTDSNAENKGAEEGTEDIDPSMDTNAENKVVEEAAEDADPSVDTNAENKEVEEAAEVADPSVGSNAENDEETEEGTEVTGRSVDCSAENEETDDATKDIDPSADRAAENKENMTKGSGNTCSGKSQTSSTVTESEDDSTEVQSSKTARNRKRSTRSTAKKMREPIPEDSADVAPPARRSTRSSRRQ
The following text describes a protein:
Function:
Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication (By similarity). The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression.
Subcellular Localization:
Cytoplasm.
Domain:
The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes; The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Sequence:
MDEGGLPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWKEQFYRYYQVARDVPRHPAATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDLTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTIRTVMVADCSRFDSPDLLLDASDQAGLPCRVFDLGGDTEEEATDPGLHTSGSDHVKKGLRRVFDSVLDGHGQLSDCALETKVAELLAQGHTKPPECNDADTRNKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPPGSVVADPMQPPPIAEEIDLLVFDLKTMREVKRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVVNSVAFSPQEQELLLTASDDATIKAWRSPRIVRVLQAPRPRPRPRPRPFFSWFASHRR
The following text describes a protein:
Function:
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). May increase NKA activity by increasing the apparent affinity for Na(+). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=In kidneys localizes to the basolateral membrane of the connecting tubule.
Sequence:
MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKAAHPTDDTTTLSERPSPSTDVQTDPQTLKPSGFHEDDPFFYDEHTLRKRGLLVAAVLFITGIIILTSGKCRQLSRLCRNRCR
The following text describes a protein:
Function:
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Sequence:
MAEEKVLVTGGAGYIGSHTVLELLEAGYVPVVVDNFHNAIRGEGAPRCRGGGTPPPLRGTVGRTGGRSRRLRLPPPGAGGVPESLRRVEEVTGRTVEFEEVDVLDGAALRGLFEKHDFAAVIHFAGLKAVGESVQRPLDYYRVNLTGTIQLLEVTEGPGEGAEVGSGRRGRTGGGGGRPSGGSGGEPGRKRKGRGSGRNRAQAPARPAPPAPAGHGRPEGREEGREAGRERLPGLPGVTLRPDSGPAPRPPPPQTMQAHGVRKLVFSSSATVYGTPRYLPLDEGHPVGGCTNPYGKSKFFIEEMVRDLCRAEEGWNAVLLRYFNPTGAHPSGRLGEDPQGVPNNLMPYVSQVAVGRREVLSVFGDDYATEDGTGVRDYIHVVDLARGHIAALGKLKENCGCKVYNLGTGTGYSVLQMVEAMERASGKTIPYRVVARRDGDVAVCYADPKLAEEELGWKAAFGLDEMCEDLWRWQKNNPHGFGAAA
The following text describes a protein:
Function:
Probably acts as a protein phosphatase.
Subcellular Localization:
Cell membrane; Lipid-anchor. Perikaryon. Cell projection, dendrite. Cell projection, axon. Cell projection, cilium.
Sequence:
MGCGPSSGRQNPSTELKKSTRATTTTTSSSQRNNYNDNNQNTSSSSGNKKESSSSSKQHSSKKSKKSNSKKNRSPSPQPQLTIKSAILIQKWYRRCEARLEARRRATWQIFTALEYAGEQDQLKLYDFFADVIRAMAEENGKGGVENGRNSPLMSALSHYAKPSLMDSEGETVKKMLEDTSPTNVDIDRNYKGPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPPVNKGMESEKENSAVNVDEWKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIGKSKQPHFVQYMASKTHRKSTLRERLGVVEESAVKELKEKLSSFHTDLQKEFEIMDIEKSGKLPILKWSDCVERITGLNLPWIALAPKVATLSEDGKYVMYKEDRRIAQVGGTHAQEKDIVESLYRHKSTLETLFRFMDKDNSGQVSMKEFIDACEVLGKYTKRPLQTDYISQIAESIDFNKDGFIDLNELLEAFRLVDRPLLR
The following text describes a protein:
Function:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins. This receptor plays a crucial role in regulating the heartbeat.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQSEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDISTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGATRMEGNLPAKLRKMNSDRFT
The following text describes a protein:
Function:
Probable bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Subcellular Localization:
Secreted.
Sequence:
MNDRISINLIYLVLTFCCVSAATVRTAKNDDIQKFTIQMIGYSPQKTDDYVAVSIEATPGYVVAFEPMAHADRVHHMLLYGCTMPASEQGFWRGMETCGWGGGSYILYAWARNAPNLVLPKDVAFSVGHEQDGIKYFVLQVHYAQPFAGEVHDFSGVTMHISQKKPMNLAAVMLFVSGTPIPPQLPAFQNNITCMFESSTPIHPFAFRTHTHAMGRLVSAFFKHDGHWTKIGKRNPQWPQLFEGIPSKLMIGSGDQMSASCRFDSMDKNRTVNMGAMGVDEMCNFYMMFHYDAKLDNPYPQGAICAKDYPSKMIDYPKDGFELLPSRPELEHHAHQSKVPFGIVQEAIHENLGGVKLGQVAGLAFNNEQQLLVFQRAGRVWDASTFDNYNILLDKKPIADPVILVISYSGNQTKLERKLGGGQFYLPHGIYVDKDGFVYTTDVGSHTVAKWKIEGNELKNIWTSGELLMPGSDQHHYCKPTGITRVEDQLYVTDGYCNSRVVVLDLNGKRIRQFGLPGEDAGQFNLPHDIVSDSAGRLLVTDRENGRVQHMTTQGHVIEEFKSTMFTNIYSAASHEDYVFMVPGRPIMGHETEGIAVFVGRSGTGLIEYAFGPTTKGKREQMGPQFGQPHCLRVCPDGGHIFVGDIAEGKARLWQFKIRHDQN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAATEGCRIVKRICDESFNLFKWLHEADIGVYKESQYHLEQTETLKQKLDSIKALFRSLRLVYEDCNRNGKIDDQEIKELLFSDNNEAKSTQRDSDKDGLTMERQELEERIKEKNQQLKIVIDQLRETTNNSNSNMFIFHTSTCNVIILSHSDFLCSKSCND
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Subcellular Localization:
Cytoplasm.
Sequence:
MKVYIIDYHKDDPKRCTGKKLVKLKIAEFTRVGKGVVLDPFAQITLSNKDKDIVRRIGITIVDTSWNNTSQSEFKNIRGEHRRIPILFAGNPIHYGIAYKLSSIEALIATLYIVDEVEEAIKLSNVVKWGHTFIELNKELLEAYKNKTEEDIKKIEREIIEKILEK
The following text describes a protein:
Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Sequence:
MPVSFCSSVTWLFHVCWVWAARMENEPFSQTSTPLTKENLKENHQTPRDIRMSDNTTLAPPASNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTGEPHRSVDFHHSTYVRPQRAVKNYRNS
The following text describes a protein:
Function:
Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MNIAQDKVVELDYQLTVRGEVLDHSEPGEPLTYLHGHGLIIPGLERALDGKQPGDDFEVIVPPEDGYGERNDEAIEELDRADFDDDVEEGETYYMQAADGTPYPFTVVSVNGDKVRADFNPPLAGETLHFKVKVLAVRDATAQELEQGYAGEEGEDGQ
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
RFLSLLSDAERNTQLLFSNVYAERMAAAARAPVRSLFAALESHLLGTPGPAAEAQLGAFFDELFPFVYFHTVNPKLNDFSDDYKACLRSAQGQLRPFGDVPTRLQGPLLESLGAARTLLRATRVALEVLNASSVPDSTPTPGCGRALAQLLGCPACLAPQHSRGELRPCSGLCLNALRGCLAGVEDLAAPWSDLVSALHRMLLRMVGSNDLEEVLSVLDSKVSEAVMHAMENGPELSKRVKLECGDPKRRLGNASSAEVAGPRRVTAALRSPNTSLRTQQRQFMQRLNDSRTLFSSLSETLCSGRGMEATHDTPCWNGAGSGEYTKTVAGVGTSAQKSNPEVSYETSLWDSRLDVLVHKLNDMTTILGNRISVMPESDSYTMEGSGSGAWGNGETSDDEDFDGGSGSGMGKSQL
The following text describes a protein:
Function:
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
Miscellaneous:
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLSAISKVSTLKSCTRYLTKCNYHASAKLLAVKTFSMPAMSPTMEKGGIVSWKYKVGEPFSAGDVILEVETDKSQIDVEALDDGKLAKILKDEGSKDVDVGEPIAYIADVDDDLATIKLPQEANTANAKSIEIKKPSADSTEATQQHLKKATVTPIKTVDGSQANLEQTLLPSVSLLLAENNISKQKALKEIAPSGSNGRLLKGDVLAYLGKIPQDSVNKVTEFIKKNERLDLSNIKPIQLKPKIAEQAQTKAADKPKITPVEFEEQLVFHAPASIPFDKLSESLNSFMKEAYQFSHGTPLMDTNSKYFDPIFEDLVTLSPREPRFKFSYDLMQIPKANNMQDTYGQEDIFDLLTGSDATASSVRPVEKNLPEKNEYILALNVSVNNKKFNDAEAKAKRFLDYVRELESF
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAQPVEQWITEIPPVTRAWVAGSIGMSLLVECQVVAPLQLYFSWKAAIVNMQVWRFITTFLYFGPVSLDLLFHIFFVMRYSRLLEENSFANRRADYAWLLFLCASFLLLVSSVATLPFLSSSLAFALVYIWSRRNPSVKMSLFGIITITAPYLPMALVLFTWVFQGGVRAAVPDIVGALAGHTYVFLQDYWPREMWSTTGRPEIQTPGFVKRLFGQEER
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm, cell cortex.
Sequence:
MNYNANVVKFHSTILHKFALKISKFLILCMRRNKRQLACMKCQCENPMAAITYADIEYPHNTHFLLLDSISWIPCTCKILKLKEFELPDRFDIPNLFYDGWLSYVFHTFSGVYLKIGYEMDESGFCLPDQVYHLIDNHSCIQTAVSHLLRNHQALFKYLCDYLRSGEFPLTVLIHHVMLYQYYPKSLQEALWAAVEHYVNNSGEAYSTVQKLAVQKKIGNIRMYLVNPRDIFALGSTCNCIVVSSSNFQSYVQLRKPLLENNLPYEIDGFDKILQCANSEADIGWIAMIHCIGSNGYAFPIHLYLNMKKNIFLGKLPESTLLLYNSDGAIFKNPPSSKKECDFYNQLLLDLCKCRQFNAEMECNMKKLFNNPTGLHSLPNLPNFSEAGSAKSSNFCSSKDNCLTNRLTLNCLDTPSDENGEDIAIQLIIPAE
The following text describes a protein:
Function:
Probable serine lipid hydrolase associated with lipid droplets (By similarity). Has low cholesterol esterase activity (By similarity). Appears to lack triglyceride lipase activity (By similarity). Involved in cholesterol and triglyceride homeostasis; has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release. Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores. May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation. Promotes microtubule-dependent lipid droplet fusion. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (By similarity).
Subcellular Localization:
Lipid droplet. Endoplasmic reticulum. Note=Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction. Lipid droplet localization does not require hydrolase activity (By similarity).
Sequence:
MDSELKEEIPVHEEFILCGGAETQVLKCGPWTDLFHDQSVKRPKLLIFIIPGNPGFSAFYVPFAKALYSLTNRRFPVWTISHAGHALAPKDKKILTTSEDSNAQEIKDIYGLNGQIEHKLAFLRTHVPKDMKLVLIGHSIGSYFTLQMLKRVPELPVIRAFLLFPTIERMSESPNGRIATPLLCWFRYVLYVTGYLLLKPCPETIKSLLIRRGLQVMNLENEFSPLNILEPFCLANAAYLGGQEMMEVVKRDDETIKEHLCKLTFYYGTIDPWCPKEYYEDIKKDFPEGDIRLCEKNIPHAFITHFNQEMADMIADSLKDDLSKM
The following text describes a protein:
Function:
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKPSSLPLHHLWLLSLIPLSLASDSTQGNSNLTCWYDSRAALLCDWNSGRDLADAPCNLMISSKYDFPDRLHCLSANSTHCVLPKAEHMTGLRRCTKIFSKNRNMQYFTTADCLSMSVHCQIGENSSIPARLENFSPLHNIKLWPPEDLQVFSKAKNTYNLTWSLNISSHYLSGERQYEVRYRTTSQSWEEAETFIISQDQMWAPFERLSPNMKYEAAVRAKPGASSTICRGVWSDWSKTVLWSTHVEGTSRPVLPAIIVSTCIFVIVGSAFLINLRTPRWFKKILKIHIPDPEKFFPPLISVHGGDIQKWLSSPFSTSSMCVNSTAPEISMLEVMQKNDEESQVSKGTLAPDPPSETSGHSVSSCFTNQGYFFFHLPNSFEIEPCQVYFTYDPFTQESNGSSDSETYHDLPSPDLCTLAEDMPALPYNFLHCINGIQGFQNISFVAETQGEAQRAMASLSRASTSPTPVLRQDEQMTDKAALQSAEDPGQVDIDFPDSPDLHDSNTSDVSSGKAGPPIDPSAPAAHATSSFSQPTTLRQTQDEDLCRTPFSSQVPNTGAYLSLKDLPSQYSHGSV
The following text describes a protein:
Function:
Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSPLILCRYLPRELSPTVDSRSCSSPLVASRAGKFLGATPPRAPRLSRRLAWCFIDWGQVCLLHRLGSGGFGSVYKATYHGVPVAIKQVNKCTRTLRASQRNFWAELNIARLHHDNIIRVVAASTRTPEGSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDIVNGLLFLHSQSILHLDLKPANILISEKDVCKISDFGCSQKLQDLRCRPSLHHIGGTYTHQAPELLKGEIATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPHWQAVFTASLTGKTLQNNVQSCWEARALQRPGAELLQKDLKAFRGALG
The following text describes a protein:
Function:
Subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. As part of the CTDK-I complex, involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing. Together with ctk2, required for ctk1/lsk1 CTD kinase activation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDPFEGRMTFLQLLGKLNASQFSQIKPAQFAIKHLDLEEDLYSCIWEELESGSFNTRVNIMYFVDTLCEMCLKNGLTGGYLNMISRDICKLVQNVAPIGAAGAANAPEVRKVLQSLHEKKVIDDNQYKDAMATVEAHEQASKSGDTSTSGAISKNDILKRIEEDRERHKRMRENIWAISEPELEAEIAWNTTQGITESDLESLKDEYEKFNECLHATS
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MSLTITVDTSCEAIVDHRIENGMLEYHVKKTSGKRRWISQYCARSCSHLILPYWLALPSSKYNGVRPPLIARHFLRIANKENVANVKQVVIKATSVNRTRLINCESLHLKDLPSCPVLTEDEKRGICCRDTYMTIDVDTASHKDKVLHCLEIAYASAVPNPKMLNSNKPGDLTYGEINEHQLRAFLLHPKITPTAADFFMDIGMGVGRATGVVSLWFPDMQGVAGIEIDPKFEEPMATFKTGLETKAKELGLGFAPLHGIIGDFTTWGKAKDVSNTFVRIMEKTTILFAHNTAFSSETNEKLEELVFQMGHGCRIITAQMLGKGKGVKRGQRQFMKTKLVFSYGEADFNSANYNILSRLDVEPLEMLENGVSYSWQQKQFFLHVVNLKKEERLKEATKMKGSRVNWEDLLKAEKGQENR
The following text describes a protein:
Function:
Plays an important role in the establishment of B-cell immortalization by acting as an EBNA2 coactivator. This transcriptional activation preferentially enhances the expression of the major viral protein LMP1. The interaction between EBNA-LP and host SP100 correlates with coactivation of EBNA2 and the relocalization of SP100 from PML nuclear bodies into nucleoplasm.
Subcellular Localization:
Host nucleus.
Sequence:
MGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPRGDRSEGPGPTRPGPPGIGPEGPLGQLLRRHRSPSPTRGGQEPRRVRRRVLVQQEEEVVSGSPSGPLRPRPRPPARSLREWLLRIRDHFEPPTVTTQRQSVYIEEEEDED
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
MTKPGDHIKRPMNAYMVWSRKERRRIAEECPRMLNSEISKRLGLEWNSLTLDEKQPYVEEAKRLRELHKKDHPDYKYQPKRKPKTSPKLKTPGLNPFMHGYGEMPGIGMPPPTNLCQPMASHMGPMVNMASCPGSCTLPEPPPPYHFSPHYSFVQNISDYKNQCGSHLSLMSRDLPYPSPIGYPSHGASHPVQFVHRSLIPDSGSVVHATSPIDARSGLARHPLDCVVMRPEGY
The following text describes a protein:
Function:
Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.
Sequence:
MFRKTHLLTWILLYNVFKVQSEATGTPTSVSLNGFGFELVMAKLQILEHHLVESNLQTEEKITIMNSRIDNLVTAVENLAWIAQQTGETVHQLGLSARHIAHNLTVIQRDLTNVVAEQKLLVTNNQLRQYQLFQSSCNASNGTINFEDHRNVYKSCNKVPFTASGVYNIRPENPFKQPITVLCDQEYESGGWIVIQHRFDGSTNFYRNWDEYKNGFGNLDGEFWLGLDRIYQLTVSQPHELVVLLEDFDGNKTFARYDQFEISNESGKYALTNIGEYSGTAGDSLQNAKGMKFSTYDSDNDVWNDNCAVSYTGAWWYGACHKSNLNGKYLRGETKEYATSMGWFTFRGHHYALKTSKMMIRPNVK
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MEKKLQSNVFPLHLKRLVDQEHLIMQFGHPKPSWKEGDVTLYRQQIRSSHPDTEEVPEFGEGSAYRYHQREELKRKRRSRSGEQNINKLPWFLDVGDGDNAKKFKGSQEGDIQTNSDYYLMTQSSNGAFQVAPVTSFIKFYSIPKHYTLNIDEAEEQMQRKEVIYDHFNFMTSKRIKQSENDKESPSSGVRLRLVERKTNEKSSSSSDYESEDESKAKARKRKQDALEAKKHKSKYGKIKVRGDEDDAESEVSDDAESEGFEVDYMSDTVSSNEEIQHKEDKPQENDGIPDEIGGSENSVYSSDENDEDLTKSGLEMKKLLNRSDNDNSDSDIPEDFDADEELSKSTVWVQNKDKKKISSEESSSSSEEESVNKSTKAKKTAAIVAKAKNNALVNLADRADFPTRVAKEKNKRSSENQPSKPAKRVKTEVGNREDSSSIASEIKDYVTPEAVARYLKRKPMTTSELIKKFKKYFKDSKDKRSINFIAEIIRKLNPERKVSGGATYFYLK
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSFIDSLATLGQYLPAVTKPKEKPSLGQKLVWSLVAVIIYLIMASTPLYGITSASFFKNLILEQIIFASTTGTLAQLGIGPIITAGLIMQILAGSKLISIDLNDPDDRVKFTEAQKGLAFIFILVESALFGYVLARTSTTINASILFIAGIVIAQLIVATYLILLLDELIQKGWGLGSGVSLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTALASHSDVLNLIVNTSTKNLFQPDLVGLVTTIALIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSDIQLFASLASYVSPSASNILNTVSGVFFFPPPNSAIPHSIYAVVLDPLGALEYAVVFIVLSILFGILWVDVAGLDPATQAQQLVEAGIEIPGVRNNPKIIEGILARYIYPLAFFSSIIVGLIAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE
The following text describes a protein:
Function:
Required for small ribosomal subunit biogenesis in neuroblasts. Plays a role in mushroom body development.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Note=Nuclear from interphase until early prophase and is then redistributed to the cytoplasm during mitosis when the nucleus is disassembled.
Sequence:
MHNSGGQSGWNLSGEERKPFSNYGRNNQQRRSSGGGGRGSHSQNRAANGNWPDAGSEGGQNGNAFNKFRDPQQELDNHQPNKRGGRRNRGGGGGGGGWGGRRGNRGRDSNRRGGRNNSWQPKDQHVSPGQSNMLYFDNVGDFTEDPPLPRSSPAPSSLRQESLPPVTFAADLTPPPPVSVAPPDVAVTPEEPTVPLINIKKEKEMEHKSKIKQFVKAEPKSPKKKKVNSSRSSSTSGEESEPEPGEMVVNTKAVVVPSPKAKAIKTPVASTPKPKAVKPVSSSDSSTSDSDTDDEQSHPPAKSKKMEKNTEEDVVCMGSQERQFTITDEEESTEPEDDKKARKQKNKGKTVDVCGICDKKGHTSFQCQMICRNCSGSYHGLKNCPNPPNLNIAIQSFVEFAMQQMTAFHCEQGFGFPAGTVTAPVSAKPKKDKKASIKKIKKSSQKRMKVEPKDHDEEDDEEDDDEDEDDSSESDDSESSEEPHPAPVSKQKRKRGTKASVSAAASLPPQVFPFPLLGAPGAPFNSMMYSYRAPFNFSK