lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MMQESGTETRSNNSAIQNGAGPGKHLLECTLRESRSNGETPLEVGAAELAHLQQQQALQAARQILINQQPLCGIKTHKRNDKQPSLQVPISVAMMTPQVITPQQMQQILQQQVLTPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLTLQRQGLLSIQPGQPTLPLQPFAQGMIPAELQQLWKEVTGSHTADDVVCNNHSTLDLSTTCISSTAHPKTSLLLNSQASTNGQASVLSLKRESSSHEEYTQNHSLYGHGVCKWPGCEAICDDFPSFLKHLNNEHALDDRSTAQCRVQMQVVQQLELQLSKDKERLQAMMTHLHVKSTEPKASPQPQLCTTFGRENGWICNSQQLEEGFTGILKGLNLVSSATLSKTASEASPQSLPHTPTTPTAPLTPITQGPSVITTTSIHNVGPIRRRYSDKYNVPISSDFAQNQEFYKNAEVRPPFTYASLIRQGILESPEKQLTLNEIYNWFTRQFAYFRRNAATWKGAIRTNLSLHKCFIRVEEEYGSFWTVDDEAFKRGRHIHRGRPRKPCPDEHFDELVAHSPSLIKNIQTSHAYCSPLSAALQASMAENSLPLYTTASMGNPALNSLANAMREDLNGVMEHTNSNGSDSSPGRSPMQGMHQVHVKEEPLDPDENEGPLSLVTTANHSPDFDPDRDYEDEPVNEDME
The following text describes a protein:
Function:
Involved in spore wall assembly.
Subcellular Localization:
Prospore membrane; Multi-pass membrane protein. Lipid droplet. Spore wall. Note=Localizes to the ascal side of growing prospore membranes in mid-meiosis II and to the spore wall in post-meiotic cells. Localizes to a specific subset of lipid droplets associated with the exterior surface of the spore throughout spore wall formation.
Sequence:
MSFTGSLALAGIGGLVYKFGGGQSYEKLPYVNIPFNQYLDKVYKKHFSKVMSRTRYVLMNFFKDAFTGGAFMYPFKGFLEFNTNKSSYSTTMLGILSSYLIMFALVSFVYWATITPMYTAFLIVLGPIGLFIAIFHSFLQANVFTLLFMRLSHFNNHLVEVCLEKNGLEENLSEVKPIKYYAPINSIYFWAYYFPFKLVKYMLGLSVLFVLLVISFFPLIGPILFHILISPFITQIYFTKVLRLQNFDNIQRRENIYLHAGQYASFGFLAGLIESVPILAGFAISTNTIGSVLFNLDHPMVPENLVETQAEIEAAPQDINQQPNQ
The following text describes a protein:
Function:
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAVPSAAIKASGVDMGDLKKRHDTKLDVEESVIDEKINENESDEKLTEKLTEKLTEKLTEKTSTEPIAYVGKCPDGTTFIVPETEDMLTNLFDPRITKSLTDVIIVSILVTFMGLFFVVPKSWRVPLYLFLFAAWRLAYNGGIGWLLHNQSNYHKLTKWALKYKVFDKDNKTWWHQLIKREFETRFQNQPNYSFYEVPVEFNTWILFRHVVDLILMSDFTCYFMLAWSCALSVRTNQPWWLVIGRWLAGALMLAFNLWAKTDAHRVVKDYAWYWGDFFFLKDMELTFDGVFEMAPHPMYSIGYAGFYAASLMACSYTLFLASLAGHAAQFVFLSIVENPHIEKTYNPHQPKQRRKASHVRDRSSIQLGLDQKQKDELSAIVEGDESVSIASTPISTTFDEPETVQKHSLPPLVVFSNFQITRVTDIMTVGAAVYTMLLYFLPANRLWYTVTFFMALSARLFHTLGLGVILRRQSERRSFTKTFLKFGIYPFEAYEQWQVWYNVSTVLSYTTFGLFCLRQWRAPSTDPLWPLKYILGALLIALHGWTSKSIHDSLGHFGWFYGDFFLDRKQNLTYSGIYRYLNNPERFFGIAGIWGLALMTNSPGVGILAFLWTLEGMAFIKFVEQPHMQRIYGTSIRHDAGVTKTIKNSLKLPSPFEKRVRQFQGSVDKVINDTLTVVEEFIGLAKPTLNEVVNDSKILLRQYPAKLTLTRMLDVPENIDTADYSVKLVGGEKCADSNRISYAFGTPIHVKWQASPNRSAKDWIGLYRVHDNTSPEVTSLPSKGRWSGIDETGHESHLDGIVSSSKTNGEVVFRGDTLFWECGVYEFRYHHAGKHTVLSTSEPFEIVAPKIDLSGEVDAKTLALEILPIVQRCFSLSMEFPPEEVDDYWALEEPKVINRVQAAVQAYFNVELAQEVLQSDESVENLAERLLRIRDALKGLTV
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MNFRLHGAFSNPSFVKIFFTKASPERRLTCFHVTKHGYSFQTDLHDYRKIMKFVISRNELGNLIKKVQNVVPQSTPIPVLTHVLIESCNDELVFTATDLTVSTRCVVKAKVYESGSVTIPSRRFFQLIRELTEANIEVAAHSGEMATITSGSSCFRLLSMGKEDFPMLPDMQNALRFTLDSERLKDMFQRTSFAVSREESRYVLTGVLLSIANGTMTVVGTDGKRLAKIDTEISLDPSFSGDYIIPIKAVEEIIRMSSEDVQSTIFLDQTKIAVECGNTLLVTKLLSGEFPDFSPVISTHSSVQLDLHREELISLLKQVALFTNESSHSVKFSFSPGELTLTANCTKVGEGKVSMAVNYTGETLEIAFNPFFFLDILKHSRDELVQLGISDSYNPGIITDSTRSLFVIMPMRLHDD
The following text describes a protein:
Function:
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.
Sequence:
MFTQLNKKLTLSSSFKTAPNIGLIKYWGKWNEREIIPLNTNIGVTLNPKDIFTTTTLTLNPETDKNQLLINGKDFHISNRIERLFGIFREQILQSKQFASNKYKNSPSDKPLGQVIPDIEKYGIRVESNNSFPTGSGLASSSSGLSALALCLQDILKTDIDVRYLSRIGSGSACRCLYGNLVLFPETISLESKRCLPYEVQSSKWLKDKVSIVILTDTHQGQKDVLSKDGMKLTWETSKLIQGRVRQYVEQHITELQSALEKQDFNKVMEIIIKDSNQFHATCMDTYPPLLYLNDFSRQIIKMVHIFNRNAKHIVGYTFDAGAHAVLLIHNDELQSFKKFLSEAENLFTKQKYIIPSQQFWTSIGEGPINLN
The following text describes a protein:
Function:
Converts adenosine-3',5'-bisphosphate (PAP) to AMP.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MQVKRIIDGAAASGLMEPLTALVVKAGEAILAVNRAAMRVDGKQDGSPVTEADLAADRVIADGLAQLAGDIPTLSEERTQLAAPPFRDSFFLIDPLDGTKEFVAGRDEFTVNLALVTHGVPLLGIVSAPALGLLWRGIVGRGAECVRFDGATIGAAEPVHTRKLPAPGEPWVAAVSRSHGDPKSEAFIDNRPNAVRRTVGSAVKFGRIAEGSADIYPRFGPTSEWDVGAGCAVVTAAGGKVTDGKGGEILFGQRQDTGFIIPEFIAWGDPQAVDRY
The following text describes a protein:
Function:
Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level. Catabolism of gibberellins (GAs) plays a central role in plant development. Converts GA9/GA20 to GA51/GA29 and GA4/GA1 to GA34/GA8. Has no C20-GA 2 oxidase activity against GA12 and GA53.
Sequence:
MVLPSSTPLQTTGKKTISSPEYNFPVIDFSLNDRSKLSEKIVKACEVNGFFKVINHGVKPEIIKRFEHEGEEFFNKPESDKLRAGPASPFGYGCKNIGFNGDLGELEYLLLHANPTAVADKSETISHDDPFKFSSATNDYIRTVRDLACEIIDLTIENLWGQKSSEVSELIRDVRSDSILRLNHYPPAPYALSGVGQIGFGEHSDPQILTVLRSNDVDGLEICSRDGLWIPIPSDPTCFFVLVGDCLQALTNGRFTSVRHRVLANTAKKPRMSAMYFAAPPLEAKISPLPKMVSPENPRRYNSFTWGDYKKATYSLRLDVPRLEFFKTL
The following text describes a protein:
Function:
In N.crassa grown under amino acid starvation conditions, this protein is required for increasing the transcription of the genes coding for many amino acid biosynthetic pathways enzymes. This transcription factor binds and recognize the DNA sequence: 5'-TGACTC-3'.
Subcellular Localization:
Nucleus.
Sequence:
MFSELDLLDFATFDGGATTEAAFASPANQTYDLSSSVPSSVSNMGTVSPQELLLHEPYLSAPSSTALTALTSPSLFDGSPDFDTFDISPNFGHSDLENPDTWFSLFPDATPLPQAQAQVQTQPQTQTQTEQQTQPLPELVQSVQPTVQPTVEQTVHSVEASPATPSEDLEVLSPGSGHQRRKSSVSPPSGRHSSVAGVGSRRRDKPLPPIIVEDPSDVVAMKRARNTLAARKSRERKAQRLEELEAKIEELIAERDRWKNLALAHGASTE
The following text describes a protein:
Function:
Plays a role in the release of TFIIB from the transcription complex during transcription initiation. Binds to TFIIB and specifically inhibits the formation of the TBP-TFIIB-promoter complexes.
Miscellaneous:
MISCELLANEOUS: Present with 7820 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSYYNRYRNKRRSDNGGGNLSNSNNNNGGMPSGLSASDAIFDLGKNKRVTVRQFRNINLIDIREYYLDSSTGEMKPGKKGISLTEDLYDELLKHRLNIDEALRRLGSKRPKTKMVRLLSDDEYEDDNNNDSTNNDKDKNGKDKNSPKKRREDKSKASNESHDLEPRSKKKKPAPPTLLPHEENIQNAEREANATLIIPGQAGRKQQEERKQKEKEEAEEAKAKAVAEQEKEAKAKEKIAEPEPEPVPTLQAKKEDIVSNINESKDANSSDEEFAQSLEAEMNKAEDDISEEE
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MTDAGAPPNSDSASQAGNAPYRVLARKYRPSSFDDLIGQEAVVRTVSNAFETGRIPQAWILTGVRGVGKTTTARILARALNYEMPDGSVKGPTIHMPNLGVHCQAIMESRHMDVLEMDAASHTGVDDVRQINDSVRYAPASARYKVYIIDEVHMLSTAAFNAFLKTLEEPPEHAKFVFATTEIRKVPVTVLSRCQRFDLRRVEADVLMKHLASIAAKESVEIEPEALGIIARAAEGSVRDSLSLLDQAIAHAAGTVKADAVRQMLGLADRTRVIDLFDSLARGDIAAAFKEFRDQYDVGADPIVVLSDLAEFVNFVTRVKIVPATADNVAYGETERVRARDFASKISMRVLSRMWQMLLKGITEVQAATRPAAAAEMVLVRIAYVADLPTPDEAIRMLEQNGGGSPVVSGGSAARSAPAAPVASAAPAVSAAPMRAPTSSPSSFGGGAARPQMAAPAPDPQAAAPQLRITSFTQLVALAGQKRDIMTKAALEADMRLVRFEEGRLEVALEPNASRTMITELARKFELWTGRRWTVIVSNEQGQPTLRSVNQAAKQEHARTAEADPRVQEVLSRFPGSKVVEVRRLAPETPESNINADYGSDDPPDGSDTDDDL
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGGHGGWSCLFVLLFLVPAFPSLHIKTHPLRPDTSRSPVNSDQHALFEALWAPSVTIDQFLHRFYRNDWLHIPAAQNDLDPRLAAADPWLDHLHRAADTWLAAELPQLVQANALTVRDAQGQITSVPAPILSNWSLLAPRLRRDHLSLVFRREQLDAQNYSVLETTLQAVFGSASTTAHAYLSAPGARALQPHTDPYDVIVVQLAGRKRWRLCTGCLNWPESDLTRFHCQSLWMEPGDVLYLPKAVIHVADAPHADETTSIHLTYSLDREGATWHHLLATAACVTPATPHASAHPDVESMQGSPLCAPVQLALRYLLASDLALPWLQIAYEPLTRADVVCQRLSALVQGPEPFTLQQAFQQTQALAWWSSQEQQLALDELSDCHAVMTRIEQAVRVSNSNKQRREAGSTATTHATLAQQLARVTRDAPWVPPGVSKQAVCNGCMLTQCTQNCQSGSECDALGCDSSCDQVLMLPTNCDGDCDPTRCYSCTQGCQKASCTSCYCPAGFCAPTNDIAINGCQACPPGTYTDALNTAPSCTFCEAATFQPASASKFCLACNTDGKLCPINQHQSSKNHRLSTCTPCDAGTEALEEGMAMCTPIKCDEPPAGPYSMVVDQAQNYSAFDIVQYGCEPLMEFATGETGARQCQSDGSWPVPPTCVPIRIGSAVTYNMTLRAEDIRPAGAVDGTAVVWPDIPMIFTTDAGDLVLRAPHVLVPMELQLSSDVQTCNGGHVAVGTTANATLSLCATSDLGRIIIWGMPRLLTMAEYDFDPVRVARLNALNATHLELTAARVVFHGAAVEFFVHGI
The following text describes a protein:
Function:
Involved in the biosynthesis of ketocarotenoids which are powerful anti-oxidative molecules. Catalyzes the conversion of zeaxanthin to astaxanthin via adonixanthin. Catalyzes the conversion of beta-carotene to canthaxanthin via echinenone.
Sequence:
MGPGIQPTSARPCSRTKHSRFALLAAALTARRVKQFTKQFRSRRMAEDILKLWQRQYHLPREDSDKRTLRERVHLYRPPRSDLGGIAVAVTVIALWATLFVYGLWFVKLPWALKVGETATSWATIAAVFFSLEFLYTGLFITTHDAMHGTIALRNRRLNDFLGQLAISLYAWFDYSVLHRKHWEHHNHTGEPRVDPDFHRGNPNLAVWFAQFMVSYMTLSQFLKIAVWSNLLLLAGAPLANQLLFMTAAPILSAFRLFYYGTYVPHHPEKGHTGAMPWQVSRTSSASRLQSFLTCYHFDLHWEHHRWPYAPWWELPKCRQIARGAALAPGPLPVPAAAAATAATAAAAAAATGSPAPASRAGSASSASAAASGFGSGHSGSVAAQPLSSLPLLSEGVKGLVEGAMELVAGGSSSGGGGEGGKPGAGEHGLLQRQRQLAPVGVMA
The following text describes a protein:
Function:
Export receptor for importin alpha (SRP1). Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm.
Miscellaneous:
MISCELLANEOUS: Present with 23500 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDLETVAKFLAESVIASTAKTSERNLRQLETQDGFGLTLLHVIASTNLPLSTRLAGALFFKNFIKRKWVDENGNHLLPANNVELIKKEIVPLMISLPNNLQVQIGEAISSIADSDFPDRWPTLLSDLASRLSNDDMVTNKGVLTVAHSIFKRWRPLFRSDELFLEIKLVLDVFTAPFLNLLKTVDEQITANENNKASLNILFDVLLVLIKLYYDFNCQDIPEFFEDNIQVGMGIFHKYLSYSNPLLEDPDETEHASVLIKVKSSIQELVQLYTTRYEDVFGPMINEFIQITWNLLTSISNQPKYDILVSKSLSFLTAVTRIPKYFEIFNNESAMNNITEQIILPNVTLREEDVELFEDDPIEYIRRDLEGSDTDTRRRACTDFLKELKEKNEVLVTNIFLAHMKGFVDQYMSDPSKNWKFKDLYIYLFTALAINGNITNAGVSSTNNLLNVVDFFTKEIAPDLTSNNIPHIILRVDAIKYIYTFRNQLTKAQLIELMPILATFLQTDEYVVYTYAAITIEKILTIRESNTSPAFIFHKEDISNSTEILLKNLIALILKHGSSPEKLAENEFLMRSIFRVLQTSEDSIQPLFPQLLAQFIEIVTIMAKNPSNPRFTHYTFESIGAILNYTQRQNLPLLVDSMMPTFLTVFSEDIQEFIPYVFQIIAFVVEQSATIPESIKPLAQPLLAPNVWELKGNIPAVTRLLKSFIKTDSSIFPDLVPVLGIFQRLIASKAYEVHGFDLLEHIMLLIDMNRLRPYIKQIAVLLLQRLQNSKTERYVKKLTVFFGLISNKLGSDFLIHFIDEVQDGLFQQIWGNFIITTLPTIGNLLDRKIALIGVLNMVINGQFFQSKYPTLISSTMNSIIETASSQSIANLKNDYVDLDNLEEISTFGSHFSKLVSISEKPFDPLPEIDVNNGVRLYVAEALNKYNAISGNTFLNTILPQLTQENQVKLNQLLVGN
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell division.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKKVWKSMDYSLLLPLVILCVLGVIMVYSSSSIVAISRHNWPANYFFKKQLITLAIGTVLLVIVASLPYKFWRKRIILSAMGLGSIALLAAALIFGKEINGAKGWILGIQPAEFVKLSIIIILARFFARRQETNTPVFKGSGLTLGFVGMAMFLILKQNDLGTDLLIAGTVGIMFLCSGVRINLWIKRIVLTSIVWIPALYFLANYKLSGYQKARFSVFLDPFNDPQNDGFQLVNSFIGIASGGLNGRGLGNSVQKYGYLPEPQTDFIMAIISEELGFIGVAIILICLLLIIIRSFRIAQKCNDPFGSLIAIGIASLIGVQTFVNVGGMSGLIPLTGVPLPFISYGGSSLIANLLAMGILLNIASHVKRQEKQQNGLMKEKEQNGPHLVVVK
The following text describes a protein:
Function:
Regulatory subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Appl and APP-BP1 interact antagonistically during development.
Sequence:
MSSPAPKSPELSDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNAITTESVTLKL
The following text describes a protein:
Function:
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Endoplasmic reticulum membrane. Secreted.
Sequence:
MVPWFLLSLLLLARPVPGVAYSVSLPASFLEDVAGSGEAEGSSASSPSLPPPGTPAFSPTPERPQPTALDGPVPPTNLLEGIMDFFRQYVMLIAVVGSLTFLIMFIVCAALITRQKHKATAYYPSSFPEKKYVDQRDRAGGPRTFSEVPDRAPDSRHEEGLDTSHQLQADILAATQNLRSPARALPGNGEGAKPVKGGSEEEEEEVLSGQEEAQEAPVCGVTEEKLGVPEESVSAEAEGVPATSEGQGEAEGSFSLAQESQGATGPPESPCACNRVSPSV
The following text describes a protein:
Function:
Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA. Can be activated by both (-)-ABA and (+)-ABA.
Miscellaneous:
MISCELLANEOUS: The synthetic growth inhibitor pyrabactin inhibits ABA-binding and subsequent PP2Cs inhibitor properties.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane. Note=Localizes at the plasma membrane in the presence of a CAR protein (e.g. CAR1 and CAR4).
Domain:
Upon interaction with ABA, the 'latch' and 'gate' loops change in conformation leading to a tight dimerization and the creation a surface that enables the receptor to dock into and inhibit the PP2C active site.
Sequence:
MANSESSSSPVNEEENSQRISTLHHQTMPSDLTQDEFTQLSQSIAEFHTYQLGNGRCSSLLAQRIHAPPETVWSVVRRFDRPQIYKHFIKSCNVSEDFEMRVGCTRDVNVISGLPANTSRERLDLLDDDRRVTGFSITGGEHRLRNYKSVTTVHRFEKEEEEERIWTVVLESYVVDVPEGNSEEDTRLFADTVIRLNLQKLASITEAMNRNNNNNNSSQVR
The following text describes a protein:
Function:
Transcriptional coactivator or corepressor of the p300/CBP-mediated transcription complex. May be involved in sex determination, early gonad development, left-right patterning during embryogenesis and differentiation of the adrenal cortex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADHMMAMNHSRFQDGTNGLHHPAHRMGMGQFPSPHHHQHTFNSLMGEHMHYVPGNMNSNNSIRHAMVTGNVNGGHPNGSIAPAARFNNSQFMGPPVTNQGAQLTASMQLQKLNNQYFTHQPYPHNHYIPDLHPTNHPLNGTNQHFKECNPKHSTGLPPSVSHVPAAILPPGVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQPNRVSC
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. Recruits the BUB1-BUB3 complex to kinetochores when phosphorylated by mph1/mps1, to support spindle assembly checkpoint signaling. Functions both in mitotic and in meiotic chromosome segregation.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MPTSPRRNSIATTDNVIGRNKSRKRPHSLGGPGALQELKEHTNPAKGILKSYSSFSVDPAFTGDEDFNDIHTQINNTVIGISSNVMAASKRLQMEDLQQLSRETSRKSLNRRVSFASHARVRWYPKDHQSDSEKSTSNHSTPERTFASDAKNHSPKGPTTTSFSRNETQSSPHSHSASIISDGSDMDIASPIRSTESDMVSEALNAGHPPPSLYPENDDLSIQNPTKALPEAEKALDVHDATREQVNDREETNMDLTIQFQEADSFLSHSESIKGLSSSEQGTVYSLKASHDPSNQTQLSSPNKSSSPTSIEISDFSKNNENHDQSENKEEEEDMMLTRPIEIPQHFSPIARPLTSQEAIVDMDITSNNINLSPVSHFSNGLDLQNLEEAPMNLTRPINANPHLTNHSPNDLTNGEEEMDTTSAFNIENSHLTLLSPIRPSSRSMEEQIMDLTQPISSTNAPTHLNEDDLNQFTSNISSSSKPRKDNNKTANSSKPIPDSEDFMDITRPFNILSPSKEALSEEQPMELTSTVFPCENSTSHLEVEEAAMDETVAFQIRGNNVELPSADKENAEREEIPSYSDKSENFNTTSFTNHERSPNGNNNLKFSKDPNSSSPSRHVVATPTDKLGTRKRRLRYSTSSFDQSTLRRNRLATIRNARKSISTLNDRELLPVNFFEKKVNSGLYKSVERSENYRLGATPLTAEKPFTTEKPLSSLPEEVSRQPTDDKGEQVSNADVDSGLSKTERLTIQQTNEIKHVPTNTTSSVKLPQQPSNEDEKERITTADYADSTSLERLESQEPNRNELVQVGSSNAGNTTSVGMNEHEKSPVKLSKGVSNVDTSLGASTINTNILNQDSGPNEEIPVGNEPEFDTMPTLPNVEPISLSDFLKMTGIEFLDNLTIAKRRETLLPNAEENKKCSIQELLESFYIQFPLLELYKFSCQQLQDYIAEGKDFVTKIEEETLKENPLLFYEYRKASSDMRVLMDSQFLMMKTFARLQAKGDWYEWREGLMQGIKHELNLNLTGMQRSLTHLMDVANVIHPYAQEIQERYNGSITTVQTLKKQKEFANQYDSTLLAQAQEKLEKLKVEVERRRRLLSEKEERRKELAIKIEQVTNSCSDLELRTNAEQDFYAKNQDFEFDEIKRYEEQLLNLKNELGWTIVSLTAGGIKLATNNTALSPYSAEVTVEILRQNFQVNVDIACKFPNESNACSSNVLEHVASSFSKWHSKVFSRNLRLLKKYLNDVSICWEQIVYLVQDFQRLWYHWPFLSVENDDKSIIINVELYLRSVSSKVKVVFGLPIDTIYQTTEVGKFYASTSVAVKQMYAESEGDSYVSEVLNTLSEVVHCTSTYALSSACLTVWNKYS
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLSDLIFIILFLIQTGVGLLENSILFILHARVFSSQAYHKKSTDLILAYLTMANMVTLLTQVAPGMVLAIIWDYSLGVVGCRIVLYIRRVSRSLTIRTTCLLSVFQAITISPSTSLWTQFKRSLPKYILPAFLFFWVLNLKVEMNILKSIESSKNVTLTIHIDSKKCCINVIFVFLMSWSSGYMVLVLYQHRKQVQHIHIQCHPATQTILLLVTCFVSFYCINSSLALALNFIKEDDLRFYDLVSFLGSLHSLLESYIFLSSHLDCPSNAHSFPSIHILHPALFLWR
The following text describes a protein:
Function:
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF12, the motif is inactive.
Sequence:
MNIHMKRKTIKNLSALENRMLMLDGMPAVRVKTELVESEQGSPNVHNYPDMEAVPLLLNNVKGEPPEDSLPVDHFQTQTEPVDLSINKARTSPTAASSSPVSMTASASSPSSTSTSSSSSSRPASSPTVITSVSSASSSSTVLSPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRSHGKAQMEPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFACSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV
The following text describes a protein:
Function:
Antimicrobial activity against Gram-negative bacterium E.coli.
Subcellular Localization:
Secreted.
Sequence:
GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLNNIGNTGCNEDEC
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDQQDQTGLQEFIPACAGWFPLDRFKALAYFEQSSFFAAAGRDANGQPITVNNTEARLAGLDPAVPGVLESLPHGRPEFVLENSQEPNAFTIRKQIRTSANPQERPLVLAYYYIANNKIMQAPSAHQVTHARLQRCTFALQQGFEKLQADLEPLTRQAKLLAKQAAREQAAAAVAAATAAAAGAGAAAAALKAGQGQGQGPAGAQERRGQGGVGTAAGPGPGSAASAASGRGGGGGPLPTPNGAVDAASGLQYTVQPYAATVDLESPSLGTLRAPLAAPLPEVMAAAAAATSTGGGGGVPVRRHLTDADRARWNKLDRILSHQFSSLQRIKYTALPPEYMQRLYGMPPPQPAAAAQAPTPAAAAAAPAGGM
The following text describes a protein:
Function:
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKDIMDAVFIKEMAKTTSNLYRLGWDERNGGNITYLLDEKEVAEYLDVKQIIRTIPMDFDGKKLAGKYFLVTGSGKYFKNVEEAPAVNLGVIQVSEDGKAVHLLWGYTDGGLPTSELPAHFMSHIARLSVDPENRVVMHCHATHLLAMTFTHELTERAFTRTLWQMCTECLVVFPEGVGIIPWLVPGTNEIGEATSEKMKENRLIVWPHHGIYGAGQSMDETFGLIETAEKAAEVYTIVMSQGGIKQAITDEQLKALGERFGVEAKAGYLNN
The following text describes a protein:
Function:
Part of a binding-protein-dependent transport system for an iron chelatin. Probably responsible for energy coupling to the transport system (Potential).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MVLEVKNLSFKYSQKLILDKLSFSVPKNSITSILAPNGSGKTTLLKCLLGLLKPLEETEIKACNKDILPLKPYEKAKLIAYIPQVEYYAFNFSVLDFVLMGKATHLNLFAMPKAKHIKEATSVLERLDLESLKDQGINDLSGGQRQMVLLARSLLQRTPLLLLDEPTSALDLKNQALFFDAIKDEMKKRELSVLVNIHDPNLVARHSTHVVMLKDKKLFLQASTPIAMTSHNLSALYDTPLEAIWHDNKLVVYAL
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MTADLRSSTCMPTGPYREPDKMEIYMNFSKNGNHQPLMNEHNQNSDTNGGPKFHQANMVKDVEDLNLDNRDPINMTSHVRIGFEEVFAEPDHQQSFDAVWTTSFIVYTQSKIWCYRLLSAALAIPLALLWGVQLALLTFCHIWWVVPCSRVWIFILNWVGSLWATCIRALCNPIAESCSILLGNVKVQMQHSPQHV
The following text describes a protein:
Function:
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine.
Sequence:
MSQRGANSRWVGNTLLLEPAQLSGADINREGQTHREGVFGTMANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity).
Sequence:
MSQLSAVPLKMTLQVDMQAQLAAIIDSTFYQVSSVFIDDLAAVNDMRNRSLMEADASVSNLEALLEYCKTLFALIAKFPDRQIEFTWFETLGHKAYGKTSNLWKFELFNVIYNIGAVKSLLASSMGNDELKEACRYLQESAGCFQYILSAMERELESVIDEKTIRAVLNLMLAQAQECCWARALRDAMKHSPIARLALQVSNFYEEAHRYARISPVIRTKLVKYINEKSFYFAAVAHYRHALHFEEKQQYGNAVRSLNEAQEKIKGAGWGPEVLPFEKELNDTLNTLQRDNDLIYLQHIPSQCPVINPVSMVKPILIDLLSTGTQKIHLFRNLLPIDVIESSAAFNIRQDKYVEDYVKSPLVALNKLLHNSLPENEALPGMKHLTEEEFDIYAKTLAGLNEFSSQLGERLTVIKSLIDGATTRLPAEANHHADQDNSKDIVEEYNKRIVTLQGYLRQGEEITRETTQIFETVDRDLLTTQLQLAATNNPTMRKVEALTKERYDYIAEVEKKSLQNRILPSLVSNYKETGSLDFEPIFQEHLKMFKKDIEYVQLGKKRNAELIAELNAEEGEESGKIKRLSPRDIQIQDFKHSLHLLEQVKENIEEGQVFYEDLKESIGVLHEDVTDFLNKS
The following text describes a protein:
Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Sequence:
MVAEKGGNSKHLRQDSKDPEAAENDVVRVYGMKFCPFTHRLKLVLAAKGVDYEIININLQSKPSWYFKRDPEGKIPTLEQNGNLVMGSDVASAYVDAMYPGKQLVTTDPLKAAHEKMLLEQWAKSITGYHNYAFGKDDNNDKIIGPMKVKEGFEKVEKYLKENEGPFICGSEPGLTDYILYPHLERIGALIPLVITQFDHVKAYYDKMQDDPAVQACRISDEQHRDFIHRACAGDIDACDIGVGK