lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSLSDEQVQAEMHKMVSFIKQEALEKAKEIHTLSEEEFQVEKAKIVREQCDAIDQTYDMKLKRASMAQKIAKSNVLNKSRLEILNSKQKVIDDIFSRVEKKLDGIEQKKDAYTKFMADLIVQAMELLGEPVGIVYSRQRDAEIVKAAIPKATEVLKSKNGSIDYELDAETDDFLNDSVLGGVVLVGLGGKIRVDNTLRARLEIVKEEALPEIRRLLFGENPNRKFDN
The following text describes a protein:
Function:
Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Also acts a viral restriction factor by attenuating HIV-1 replication. Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation; (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR.
Miscellaneous:
MISCELLANEOUS: The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membranes via an N-terminal amphipathic intramembrane region.
Sequence:
MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG
The following text describes a protein:
Function:
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVKRVLASAPAKIILFGEHSVVYGKPAIAAAIDLRTYVSAEFNDTGAIKIEAHDIRTPGLIVSFTEDSIYFESDYGKAAEVLGYVRQAIELVREEADVNGKGITVSITSQIPVGAGLGSSAAVAVATIGAVSRLLGLELSNEEVGKLGHKVELLVQGASSGIDPTVSAIGGFIHYQKGKFEHLPFMELPLVVGYTGSSGSTKELVAMVRKNYEEMPEIFEPILNSMGRLVEKAREVITSDLDRELKFQTLGKLMNINHGLLDALGVSTKKLSELVYAARTAGALGAKITGAGGGGCMYALAPGKQSEVATAITIAGGTPMITKISREGMRIEEVEE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MALQQEDLKALEQTRQRLLHLTSNIASLKTGFQRGAPLPEYSSVMTSSSILSTNIQSVIDHLAANSEILSRIVAFPSTNFPGRTQEGLLLQLLRKKLEPQVETWVEEGRNLQIDGAGEGANQGDLEETWKWAAEWIGPRIREYALNEAGDEYTAEERESGVENVNTGLKDEEESDEEDEEGDEDDEVMGGMDRSAEKKKAPEKIIMRKDGRVRSKEEILRFAASGVI
The following text describes a protein:
Function:
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MALSPQLFFALYVSAFALGFPLNLLAIRGAVARARLRLTPNLVYTLHLACSDLLLAITLPVKAVEALASGAWPLPLPLCPVFVLVHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAVRRPRYSWGVCVAIWALVLCHMGLVLGLEAPGGWLNTTSSSLGINTPVNGSPVCLEAWDPNSARPARLSFSILLFFVPLVITAFCYVGCLRALAHSGLSHKRKLRAAWAAGGAFLTLLLCLGPYNASNVASFVNPDLGGSWRKLGLITGSWSVVLNPLVTGYLGASPGRGTVCTTRTQGGTIQK
The following text describes a protein:
Function:
Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKQRIFEVLITNICEVLPELDGHRFEPEDQLVELGADSVDRAEIITMVLEDLSLKIPRIELSGVKNIGELAEVLYDKVQSA
The following text describes a protein:
Function:
Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters; DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MHTRTHIQTRRLRVLCQSLEHPQGGASILRTCAQGERRKERKEMRMEIRGNSLRMLCACPCICGTWTPSGGRPAARHGVVPFPLLVTRRQGVGLGELREWRVHARRKLFTSLSRAEARGQRKKWVRAGRRMAVSGPAGPGSGSGLQLPTFAAARALVKPGSCLSVGPHRRHVALAPRFLDRKRSGLREQLDRELLRYSESLRGVPVAYDNLKIVGELGDIYDDQGHVHLNVEADFVVFCPERGQRLLGTVNKVAPSHLGCLVHGCFNASIPKPEHMPAEQWQGLHFHVGDELEFEVSRLDSDAAGVFCIRGALIVSSLPPVFPALPEGSENAGHEPEPGIGEEKPKKKSKKDLKQPRLDGGLKEAAAPSDEAGTVEIDPQAQEAVNGLCEEEQEPPAKKKRHREEPEQDPLWHASDSSGYQSDHQKKKKKRKKHSDEPEGPVAPEEPRPKRKKKKE
The following text describes a protein:
Function:
(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=A higher concentration of RFPL3 is observed in the cytoplasm compared to the nucleus.
Sequence:
MKRLSLVTTNRLSPQGNFLPLCTFPLAVDMAALFQEASSCPVCSDYLEKPMSLECGCTVCLKCINSLQKEPHGEDLLCCCCSMVSQRNKIRPNRQLERLVSHIKELEPKLKKILQMNPRMRKFQVDMTLDADTANNFLLISDDLRSVRSGLITQNRQDLAERFDVSVCILGSPRFTCGRHYWEVDVGTSTEWDLGVCRESVHCKGKIQLTTELGFWTVSLRDGSRLSASTVPLTFLLVDRKLQRVGIFLDMGMQNVSFFDAESGSHVYTFRSVSAEEPLRPFLAPSIPPNGDQGVLSICPLMNSGTTDAPVRPGEAK
The following text describes a protein:
Function:
High-conductance voltage-dependent solute channel with a slight selectivity for cations transporting triosephosphates, dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and positively or negatively charged amino acids.
Subcellular Localization:
Plastid, etioplast membrane; Multi-pass membrane protein. Plastid, chloroplast outer membrane; Multi-pass membrane protein. Note=Present in non-green root plastids.
Sequence:
MKAALKGKYDLDHNSSGAATVAFNAGDVKLRASITDATFKNSPSLTGLVLAVEKPGSFSVDYNVPKKDFRFQFMNTVRVAEKPLNLAYIHSKGDNRTILDGTLVWDPSNKVSANYAVESGNCKLKYSYNHKGLTTIEPTYDVAKNSWDFAVSGKVYGDDSLKASYQTSSKVLGLEWTRNSKQTGCFKVVASVNLAEEKKIPKLSVESTLNFEM
The following text describes a protein:
Function:
Required, in concert with Hsp40 (YDJ1) and Hsp70 (SSA1) and small Hsps (HSP26), for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by components of the Hsp70/Hsp40 chaperone system. Substrate binding is ATP-dependent, and release of bound polypeptide is triggered by ATP hydrolysis. Also responsible for the maintenance of prions by dissociating prion fibrils into smaller oligomers, thereby producing transmissible seeds that can infect daughter cells during mitosis and meiosis. Loss of HSP104 can cure yeast cells of the prions [PSI+], [URE3] and [PIN+]. Excess HSP104 can also specifically cure cells of [PSI+].
Miscellaneous:
MISCELLANEOUS: Present with 32800 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus in an importin KAP95- and KAP121-dependent and an exportin XPO1-dependent manner. Accumulation in the nucleus is enhanced by severe heat shock. In the cytoplasm, concentrates on a perivacuolar compartment, the 'insoluble protein deposit' (IPOD), in which terminally aggregated proteins are sequestered. It is also found, to a lesser extent, at a 'juxtanuclear quality control' (JUNQ) compartment, where soluble ubiquitinated misfolded proteins accumulate.
Domain:
Has 2 AAA ATPase type nucleotide-binding domains (NBDs) per monomer, a low-affinity, high-turnover site (NBD1) and a high-affinity site (NBD2) with a 300-fold slower rate of hydrolysis. There is allosteric regulation between the 2 sites. ATP binding to NBD1 triggers binding of polypeptides and stimulates ATP hydrolysis at NBD2. Nucleotide binding to NBD2 is crucial for oligomerization; The C-terminal extension is involved in oligomerization.
Sequence:
MNDQTQFTERALTILTLAQKLASDHQHPQLQPIHILAAFIETPEDGSVPYLQNLIEKGRYDYDLFKKVVNRNLVRIPQQQPAPAEITPSYALGKVLQDAAKIQKQQKDSFIAQDHILFALFNDSSIQQIFKEAQVDIEAIKQQALELRGNTRIDSRGADTNTPLEYLSKYAIDMTEQARQGKLDPVIGREEEIRSTIRVLARRIKSNPCLIGEPGIGKTAIIEGVAQRIIDDDVPTILQGAKLFSLDLAALTAGAKYKGDFEERFKGVLKEIEESKTLIVLFIDEIHMLMGNGKDDAANILKPALSRGQLKVIGATTNNEYRSIVEKDGAFERRFQKIEVAEPSVRQTVAILRGLQPKYEIHHGVRILDSALVTAAQLAKRYLPYRRLPDSALDLVDISCAGVAVARDSKPEELDSKERQLQLIQVEIKALERDEDADSTTKDRLKLARQKEASLQEELEPLRQRYNEEKHGHEELTQAKKKLDELENKALDAERRYDTATAADLRYFAIPDIKKQIEKLEDQVAEEERRAGANSMIQNVVDSDTISETAARLTGIPVKKLSESENEKLIHMERDLSSEVVGQMDAIKAVSNAVRLSRSGLANPRQPASFLFLGLSGSGKTELAKKVAGFLFNDEDMMIRVDCSELSEKYAVSKLLGTTAGYVGYDEGGFLTNQLQYKPYSVLLFDEVEKAHPDVLTVMLQMLDDGRITSGQGKTIDCSNCIVIMTSNLGAEFINSQQGSKIQESTKNLVMGAVRQHFRPEFLNRISSIVIFNKLSRKAIHKIVDIRLKEIEERFEQNDKHYKLNLTQEAKDFLAKYGYSDDMGARPLNRLIQNEILNKLALRILKNEIKDKETVNVVLKKGKSRDENVPEEAEECLEVLPNHEATIGADTLGDDDNEDSMEIDDDLD
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MVDSKKNKKQQVTDFSNLLSQSKGFVIFDYSGMSAVDATLMRKKLFNKGSKIKIVKNNILRRALKTSNFEGVDESVIKGKIAVAVGINEILETLKVVDSVVKEKELMKFVCGHFDNRIFNSDDLQKIAKLPGRNELYGMFLSVLQAPLRKFLYALQAVRNAK
The following text describes a protein:
Function:
Absolutely required for transposition of IS1.
Sequence:
MPGNRPHYGRWPQHDFPPFKKLRPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVEQHDKVIGHYLNIKHYQ
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).
Sequence:
MTHKLTPMMQQWHQCKEQAGDCLLLFRLGEFYEAFFDDALILAQNLDITLTQRQNVPMSGIPATCLDGYVDRLVSRGFKVAIAEQADNTEGSKGLVPRTINRLITPGALLSSSLLPEKANNYVLAINQVGSLYGLSCLDLSIGTFLVAEYDNTKDLIEAICRLAPTELLSHAKFYQKNEAVIKQLQQHLRITLSEYVSWAFEYQSATKKLYTCFQVSSLDGFGLQGLVPAINAAGALLSYIQDKLLLPISHLSIPKIYGQQKHLLIDKASQTNLELLSPIHGEHGKGSLLQVMERTSTPMGGRLLRNTLINPFYDLKEITLRQDSVEFFLQQADLRKILKRQLSCVRDLERLATKISTSLATPKDIGTLRDSLLSCTHIADNLQNCALPEFLENKFLIAPPLCSLIKTLSTELIQELPLKVSEGNIFANHYHPDLLRLRNIKENSKSWILEYQERIRNETGIKKLKVCYAQALGYYIEVASNLAPQLPKEFIRRQSRLHAERFTTQELQQFQDEVFSVEDKLQTLETKLFKELCFYIVEHRDLILKLSTAVADLDYVVSLAELAAEYDYRRPLVDHSDALSITKGMHPVALTLLDKGTFIPNDTVMHSAQTRMILLTGPNMAGKSTYIRQIALLVIMAQMGSFIPARSAHIGIVDKIFTRIGAGDNLSKGMSTFMVEMAETANILHNATDRSLVILDEIGRGTSTYDGLAIAQAVVEFLLFTDGKKAKTLFATHYKELTELEMHCQHVENFHAMVKENSGQPIFMYEIVKGHSKKSFGIHVAKLAGFPLSVVSRAQQILHQFEGPDLRPEPEKAQQLVMF
The following text describes a protein:
Function:
Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nuclear import and export are mediated by the importin PSE1 and the exportin MSN5.
Domain:
The C-box is required for the association with the APC/C complex.
Sequence:
MSTNLNPFMNNTPSSSPLKGSESKRVSKRPISSSSSASLLSSPSRRSRPSTVYGDRYIPSRTDIDFNSIVSISSMASVPALNPSSTEDQVEYQKERQAHETYNTLLKNELFGEMLSKDTVGSESSIDRIKNTRPSTRGNVHAENTTRHGYELERVSTPPPEAAGLEEFSPHSTPVTPRRLFTSQQDEITRPSSNSVRGASLLTYQQRKGRRLSAASLLQSQFFDSMSPVRPDSKQLLLSPGKQFRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDKPKAKVQPNSLIFDAFNQIR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATLEDLKFYPQNQLNYYYDQNSSTVCRICLEKAQNSKKMCNIFEGNEPIFTMIMSCASIQILQGDGLPNTICQKCLAKLNVAWQFKLQCESSDLRLRQFYTDSTVLSFTETEKNFDETPATSQVKPPETKKTKKRPKESNIHQCETCGKIFNRREYLTQHIRIHTGEKPYCCHICEKRFINSGHLTTHMRTHTGERPHACSLCPKAFSTRQELHKHTMVHNGERPFVCTTCGKCFGSSSNLYSHLRHHTGEKNFTCEHCGKAFYTKQELKQHLVVHTGEKAFGCKFCSKRFSQSAHLRRHLKLHA
The following text describes a protein:
Function:
Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIIRDFVLSWYRSVSHEKTFEAEMEASMKGLVQELRRRMSIVDSHALTQRVLTLCGCHLQSYIQAKGATAKEQSCPVEPSQLWDAYCQVTTPHPAMSCPTTEVTYARGIVNLILKELVPKPHLETRTGRHVVVELITCNVILPLISKLSDPDWIHLILVSIFSKYKQDAAQGTKPPSSPCVLEQPSVPTSLPLMVEVESLPVGKASSPVAAPVHLASSEPAPSPEIEEGHEAVEGELPGMLEERKVGNNSSHFLQPDIRGPLFLCEDSELESPLSELGKETIMLMTPGNFLSHRIQDALCALDDSQALEPRDGEGSECMEGAEAEEAPGAETETGTLVSMLNCPEIQIDPADKEAEQGDDASLTALLEEPEKPCLQRPSCLDKGLGSGACSLEPAVPPLSLSSSPPGPLSSATFSFESLSSPDGPVVIQNLRITGTITAREHSGTGFHPYTLYTVKYETALSGENSSGLQQLAYHTVNRRYREFLNLQTRLEEKPDLRKFIKNVKGPKKLFPDLPFGNMDSDRVEARKSLLESFLRQLCAIPEIANSEEVQEFLALNTDARIAFVKKPFMVSRIDKMVVSAIVDTLKTAFPRSEPQSPTEELSEAENESKPQTEGKKASKSRLRFSSSKIAPALSIAEAQDKILYCLQEGNSESEVLSMSGMESFIEKQTKLLQMQPAEVPDKEPQQVPKESVDSGLLDKAVVSQELNKSDPGTETELADTAFDLILLLLMEQWKWLCTENMQKFLRLVFGTLVQRWLEVQVANLTCPQRWAQYLRLLRESIWPGGVLPKFPRPGRTQAQKAATEKQALQSLMGLLPDFLVEILGVHKCQLSWSLVLESFQQPLINRHLIYCLGDIILEFLDLSAAVEECAPTTSASDSPGSLKKMAVST
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MARSPLLAAAVALVVVAGAYAASEQDELKLRPPPVAPFDFYKRSCPKAEFIVRDFVQDAVRKDVGLAVGLLRLRFHDCFVQGCDTSLLLAPGEQQAPPNLSLRPSAFKAINDIRDHLERECHGAIVSCSDILALAARDSVVATGGPDYRVPLGRRDSPWFATRDQVIEFLPRPSSNGTTFLNVLHKLSHNLDATDLVALSGRHTIGVCTSFEKRLYPRPDPTMNPSLVASLKQTCPAEGTVARTALDVGTPKVRQPERLYQRPDPTMNPSLVARLKQTCPAEGTVARTTLDVGTPKVFDNKYFLNLLDRKGLFVSDQDLFTNAITLPMIKVLTSGQGQICRNCAVRNPGTVDGLERSSIVQTVIDATAESLGVLESV
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Sequence:
MALVFLGNSALRRVSKSVADVRAPAVRRLIEAMETEVRQEAGVGIAAPQLAHNLRMFLMIKNMPENEDDLDKLEYQEVLNPEIVAMSSVTKRDFEGCLSVPGYQGIVKRAEEIRVQYEDGEGRKIQETLTDFPARIFQHELDHLNGVMYLDRLDPGSLIHNEEFEAMEWLDIQQLLLQGPPKIPPLMVSMPTDRPAKGKGKHKNKY
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MCKNIPRYRMKVLIFTLGLLAALALSQDVKITDAERTVDISSQLAKVNVALTVQNNGKSALSDVLFYITTDEAAHLAHIAATIKKKDVKVQPQSAVQGFAVYKVVLPKKIEAGASETINVEYVLVQSLVPFPEQITQEETQHVVYTGNAHISSAYPVEKEKTTVIFGSGKLQSFATVAPSKQLGEKVVYGPYSNTAAKAISEIRVHYENVSPFIVATTVERLIEISHWGNIAVEEKIQIVHKGAKLTGSFSRLDYQIDRRGKKQPCVKEFKTILPAAARDIYYRDVIGNISSSSLKVRAESVEVDVKPRFPLFGGWKTNYIMGYNLPSYEYLFADGDKFVLKMRLLDHIYDGMVVEKLTTKIVLPEKASNVKLSTPYTVNRRPDEKLATYLDTEGRKVIVIEKNSLVDAHIQPFTLEYQWSRLYIWREPLMATGFFLCLFLAVIVYVRFDFEITKDSASEALLGVQAKVEEVEKIVNERIAIHKRLIEAVSTFKGDKEEETLKNTRAKIETERAELKKKMSGIVGQMKTLLPAASEKLNEMEQLESGIVNSESAYIEKTSKSTTKNSSEDRQWTVRVNGDTNKMKDIINSI
The following text describes a protein:
Function:
Transcription factor that may transactivate seed storage protein genes in developing seeds.
Subcellular Localization:
Nucleus.
Sequence:
MLSHVEMAPAAGGFKLFGKVIMQCGVSEGTQDKAQGFVVAREKVEPEEEEEEEQRVPAAATSGQRASIKREAADRDEEQRQGGGDAAGQPTQRRLQDSAEARAAAAAPLPCPRCRSRDTKFCYFNNYNVNQPRHFCKACHRYWTAGGALRNVPVGAGRRKNRPLGPLAVAHHNHHHRAAAGFVLGFPNPSSPTSPSPVYTDRWPVTPDRPF
The following text describes a protein:
Function:
May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
Subcellular Localization:
Secreted.
Sequence:
MRGTPKTHLLAFSLLCLLSKVCTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MWYEILPGLSLMAVALMIPGLATIQIHKFTNGGKEKRVARVPWQWYLMERDRRVGGTGHYFDSKVKPYFEREN
The following text describes a protein:
Function:
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Sequence:
MTLEEVRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVYESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGADDEGGAPGDLHCILISNPNEDTWKDPALEKLSLFCEESRSFNDWVPSITLPE
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
Sequence:
MATATAPTYTLFLGTFIHLPRKPTGADPGAKWRPALEINHGALWVSNSDGKIAGFDWSFSPADGDVNSLTEKLGLSGKVTEVVRAREERNEFFFPGFIADRQDTHIHAPQYPNSGIFGSSTLLDWLETYTFPLESSFGDASKARAVYSRVIARTLANGTTCASYFATIHVPATNLLASLCHSRGQRALIGRVCMDNPSFCPDYYLDSSPESSVSKSKETIAHIHSIDPAGTLIHPILTPRFAPTCSPPALHGLAQLAQSYNPPLHIQTHLSENTGEISLVRELFPQSKDYTSVYDDFGLLTPRTILAHAVHLSPSERELIAARGAKVSHCPASNSALGSGLCAVRKLLEAGVEVGLGTDVSGGYNCSVLEAVRQGCLVSRLLRHSGTDDPGDGDDGEEVLSVEEGLYLATRGGAAVVDLAGEIGGFEVGMSFDAQMVRLGHSHTSSSPTAEHGVVDVFGWESWTEKVHKWVWTGDDRNVKAVWVRGRLVHSLDEGQSQSDVSIPEKGKPTWIWAGTGAAWESKWWLCGLGFVSAWFIFDRVMR
The following text describes a protein:
Function:
This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Periplasmic side. Periplasm.
Sequence:
MTGDNTLIHSHGINRRDFMKLCAALAATMGLSSKAAAEMAESVTNPQRPPVIWIGAQECTGCTESLLRATHPTVENLVLETISLEYHEVLSAAFGHQVEENKHNALEKYKGQYVLVVDGSIPLKDNGIYCMVAGEPIVDHIRKAAEGAAAIIAIGSCSAWGGVAAAGVNPTGAVSLQEVLPGKTVINIPGCPPNPHNFLATVAHIITYGKPPKLDDKNRPTFAYGRLIHEHCERRPHFDAGRFAKEFGDEGHREGWCLYHLGCKGPETYGNCSTLQFCDVGGVWPVAIGHPCYGCNEEGIGFHKGIHQLANVENQTPRSQKPDVNAKEGGNVSAGAIGLLGGVVGLVAGVSVMAVRELGRQQKKDNADSRGE
The following text describes a protein:
Function:
Fumigaclavine B O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde. EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline. EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine. Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A. Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus.
Sequence:
MKKQVTFKPFRLSPVDHSLPKVYIFKSLYFRGVDDTGSLSRLQDGIDRLISCLPFLSGEVVPCADIPDKVGVLQVQMPCPSLQEIPMLLVKSYPNHTWPAASTSERWRNTALLDQSYRPLPDFIPPSKPRPVLRFQANFLADGLMLCMGYNHSVFDGTGAGNILEMLADCCRANPNSILALPTNGDIESELRGLLSSPGVAVANASQEAYAINCAHTEVEPEPSSAMLYCWPFLLSSEKIECLQEACNSLLPHIVRLYSGTQSSLINQDTNWPHILSSNDVLTALLAVSIEKAREATGALGHMSRSLAMAVNLRERLKPMPRHYLGNLVTTVWVSHHRPAVKDLETMVLPVPACNRHEIDRDDLLWITHVAFRIRLGLNAINEEHIRGLIHYLHSQDDWEQIGIHFTDPIFISSWRHLKVYELDFGPTIGHAEHFEMDVGTTDGVCVVMPANTRAVGKTKKAPWDIRIVLNPEVLQALIASAIFGWAMVKDAST
The following text describes a protein:
Function:
May be involved in vesicle transport between the ER and the Golgi complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPMILYACIVRLQDGLPLSASSDFHLNKQLLECKRKLKALTLTISQQPPRGTAKVFDFNIHFCSAADISSLAICSGTYPSAMAFCFLDELLWDFSASYNRTAIALASRPYSFLEFDSLIQRVKHNFNFAVDPPVQIDPSPPPVFVKLDEVEERNGTLNGYASSHPQPAPNCRMTPVTALGILSLTLNIMCSALSLIRGVHLAEHSLQDGYENVGRVVAFLTAFSANILQCYLYLFHCSARKRKACGLLGIICLCNAYLYGLRNAWQILFHISVAALSAQQILTRKPLDKGSCPGV