lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end. May be involved in cell motility or cell differentiation during prestalk formation.
Subcellular Localization:
Nucleus membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MESPVVEGNSGEVATPTLPQPPTPVSSNIRVVCRVRPLTELEKGRNEHSIVHFFDSKSISIRANGPQFTFDRIFGYQETQSQIFEDVAEPIVNDFLDGYHGTIIAYGQTASGKTFTMVGDPDSHGIIPRVIESIFVGISKMREKDTSLSLAFCLKISALELYNEKLYDLYDASKSNLNIREHKQNGIYVEGISEIVITSIEEAYNFLNISNNNRAIASTKMSAASSRSHSVLMIELSQQNLSMESSKISKLFLVDLAGSERAHKTGAEGDRMQEAKNINLSLSALGKVINALTCGANYVPYRDSKLTRVLQDSLGGNSKTSLIINCSPSNNNEHETITTLQFGTRAKTIKNQPKINKKITYHELELFIIKLAKDLEKSRKECEEITRSKNLEINNLLIQLENNQKMVVESNQKLELLNSQISSNHSFDNTFKEIENTCENSKIIFDDLNDHINNNNNVDENNNTNNNDNNNNDNNNNNQYQEESNQYQQENNQKDGDQNNSSFDSIKVEDLRDLDDEPDIEDIILNSTLGNISDDDDDDDDHHSNNNNVDDNNNGEINNDSDGYLNRSLKDIKIPEISDLNDHNINNNNNNNNNINNDNNSNSGGLRVSTSYITSSPNLSPSKSMDVNNSPPLFSYFKTKDFPPSSDENDKFFNDLIAKGENEQQQQQQQHNDDDEDIKSTTSNATTTTITTIDMNASHPSGIDDPIEFTIIKSDKTITSTIERETIQPSSLSNSTSLLDIETVESSTLPAPPPVTTTTTLTTVTTTKLTKTTNIPSNTNDINSIDDFGFSKIEEEGSSSNRKPNDTAILSFGDDDDEENEDNENEDVIVDSDEDTHSGKNNLLNTFKNDHHRGDFGATPTKSIFNKNGNITIKEFETPQQQQQQQQQQQQQQQQQQQQQQPLILQTTSTNPTIISIKSNKEPSPSSSTTTSIKKKNFNKRRSWIIFTIILTITLVSSSLLCLYLPEYKERLVQRRGYLNKLGIYSDYPTNEKISLAQHNQISLAKELYGGNSKQYYDEMSSFNTAYNHLIEMNHLETAVSKIFGSAIDLRFSGDDVINSIECKRAIHKLKTNNYVNGDLDQQQQQHNYITKIDQLSEQSKEQNQLIENFKLDLKNKTSEIEKLEKEIKQKDNKIKEKEEKIELIESRVLNEEKGGEKVLEDQIISLRNDKNTLSTQILNLEGDKKSLGVLVIKLNSDKTEIQNEVKELKRKVQELEDAPIALIPNPFVKWVKSFYVEKKSWFVENIYKIWNWFK
The following text describes a protein:
Function:
Nucleotide kinase that catalyzes the phosphorylation of dGMP and dTMP to dGDP and dTDP (Probable). A double mutation in this protein and the RecBCD inhibitor gp5.9 protein allow phage to overcome the retron Ec48 bacteriophage defense system. This protein alone when overexpressed in E.coli does not cause growth arrest; Y128C may be a silent mutation.
Miscellaneous:
MISCELLANEOUS: [Isoform Small gp1.7]: Produced by alternative initiation at Met-42 of isoform Small gp1.7.
Sequence:
MGLLDGEAWEKENPPVQATGCIACLEKDDRYPHTCNKGANDMTEREQEMIIKLIDNNEGRPDDLNGCGILCSNVPCHLCPANNDQKITLGEIRAMDPRKPHLNKPEVTPTDDQPSAETIEGVTKPSHYMLFDDIEAIEVIARSMTVEQFKGYCFGNILKYRLRAGKKSELAYLEKDLAKADFYKELFEKHKDKCYA
The following text describes a protein:
Function:
Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
Subcellular Localization:
Nucleus.
Sequence:
MYVGYVLDKDSPVYPGPARPASLGLGPQAYGPPAPPPAPPQYPDFSSYSHVEPAPAPPTAWGAPFPAPKDDWAAAYGPGPAAPAASPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITATPAGPSLGGLCPSNTSLLATSSPMPVKEEFLP
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADTEDDNSALASFFPDPPLFWKAFTPSNLQAYAEIKQQYASQHGIPVEDVVRVPDLPADSDLIYLQPPAEPKDGTWRLYGEPQSLEESLQPLESAGIERLGPPLPGSTTTSTSNTQTTTTDSQSTTQPTTDDTQPTSAFPSQQPTSQLPLPPSSTSAPGGASSGASSTQTHDTLHLHLKRLSKSLLLNFLELLGIMSLDPAAGSQKAADLRTLFLNFHHVLNEYRPHQAREQLIQLMQERLDQTRAETAANRAVAEKARRVLEGLGSVEIPAVDDVNIAGTGTGGGDGEAGYGSAAVPVPVPVGARTGTTVGDRRVGVDGEGAEEEEKMYWEREGMGWGVLDAEFA
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRFFINNIPFVNGGSLLLSGQQHSHLKKSLRLKVGNVIEVFDSNGQNCQATIIDIGKNETKIKLQLDSNKALKKDNKNSIINENSNNNKEDIDEIINMNNNNDNNNIDININIDLATSLPKIQRAEWMIEKLTEIGVKNLFLLESEYSKSSPSSGSLTSNKLDRFERIIIESSKQSKNNHLMNIIPPQPYKQFLKDKFNIDTIKQSKYSHIFLFDPNGKPLPLIFNEIKENNNNNVRDTLILIGPEGGFTNNEINQLQQTIDKRNDSNFYISKLGNTILRMETAAIVKSELILSVYMNDYIHFFYFLYNFVYF
The following text describes a protein:
Function:
Putative GTPase-activating protein.
Sequence:
MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10. When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation.
Miscellaneous:
MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore (By similarity). The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex (By similarity); The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity.
Sequence:
MSFYSNLPSAGQSSRGSSTSGRNGVGLEPLYPTIFEIMSSQEIDSLLPASIRYLLANHLVANFPNRYTLRLNKYFFEWFQAIKGFVEWYHLKTYNSTFIDRFYGLQLFSSRDRNLALTQCLNPKGQSEWPQGLQLNQQQKSVIFLEKIILPYITAKLDEILEKISMNNIFSSDETENKWPKRAFLRIYPFIKKLLALSNLLVKLLFLTKRTGSVSLLQYLFKIEYTTVRPLSSELSGLKETKGMDNRLRKTNISSIFALMQGQLSIIPRFLTFMGSQFFPTFIFVLRVYQWWTTQDMTTKLQKRVNDLDEDIPRPPFSSHSDKTEDKEGVSEACPVCEKTVQNPCVLETGYVACYPCAISYLVNNEGHCPVTNKKLLGCTYNKHTNKWEVVTGIRKLLI
The following text describes a protein:
Function:
Plays a role in the regulation of neuronal activity. In AWA and AWC neurons, plays a role in regulating olfactory adaptation by controlling the forgetting sensory responses to odorants such as diacetyl and isoamyl alcohol. May play a role in regulating daf-7 expression in ASI neurons in response to bacterial small RNAs. In ASI neurons, promotes dauer formation in response to pheromones such as the ascarosides ascr#2 and ascr#3.
Subcellular Localization:
Rough endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Restricted to neuronal cell bodies, absent from dendrites and axons.
Sequence:
MMQQQKPGKPKKINRIDKIKRLQINRSRRPDINQTVPSPLFYVRIVVTWLGMVSLDAMTGFRFELLWPTWLMIRAAAESIQMRNQHCVTTIANPTAARFSVLFICVTATSDLICYLFIPIRMLIFLATTYVWISLYYHTQGGFLRSLATVYGGERLQSWPIVFITCFIVIFELFLRIRSHPILISFFPNVAEYAGVSPVWPRSLNAFFGAHSIGYPVILITVSMHYYFNEWKLRRKQCDVSNRNEQLFRILVEGLPAEYEGPKDYTSQQCLEDDLYYLDPPVQTLQPMQAIQAASATPPTSSKKNGIHKRNGDVTSSTTTSSRKKKHNGNSGFNSTPPNDKKKGKSIRDVDMDDGDDSDDDYSYRDTSSSTIEDQRRGGGISIIRFIFSSAAWLFSFVFESSTPSENSLSNQQIDDDEDYEDGDGDKKNGRTDSMTSTTKGRANTMPSTTRSQNNNNSQKQQKQSNGKSHHQHSSHQNNHQKSNGNSNGHARGFAAVRDSSHDTNASNETDIRSMSRELESLRSEISSRRSQEEDFKLQVSMHESNETRLSQQLSNMRLKVEQMEIKCSSIERHRESDKHQLEQAERKYADLLGKKAEIEATLSAERKARMEVTSKKYDVAEHQRERERQLESEIDKLRIELKSKDESNMRMESELHGLRNYKEENDIDSLNMELRFVRDKSHQMEESLAGENKLKQSLFKCLGDARDTIKSLERRVQEFQIKNGSSIGGGSSETLMNGRSSTEANNENDTTASDQSSPHQHSAMGSPVPFAKMPLSVNVSNRHGSPFNGKVSPIASIGSVLAAAGGPAPPDYMMAVGANVTATTGPVPQKQPRAGFHGISRYNEFTNIASGGEHRLFDTPASAISASAINGSNPEDDFLMNKGKFGAPSQPAARLA
The following text describes a protein:
Function:
Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion inner membrane. Nucleus.
Sequence:
MATALALRSLYRARPSLRCPPVELLWAPRRGHRLSPADDELYQRTHISLLQREAAQATYIDSYNSRGFMINGNRVLGPCALLPHSVVQWNVGSHQDITEESFSLFWMLEPRIEIVVVGTGDRTERLQSQVLQAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGGTSLKPLGQAAQ
The following text describes a protein:
Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSQHTASTSPDASSTTQVAGHPSSATSRAAELASLKVKLRGALRQFPDFPSPGILFEDILPIFSDHSTHEALVRCLELHILETLADEKPDVIVGLEARGFLMGPSLALKLGAGFVPVRKRGKLPGPCETQGYEKEYGQDFFQMQSDAIKPGQKVIVIDDIIATGGSAYAAGELIKKMGGNVLGFVFLLELEFLHGRDKLSAPVHTLLTGQETKA
The following text describes a protein:
Function:
Confers resistance to heavy metal ions (e.g. aluminium (Al)) by chelating them at the plasma membrane of root cells, thus stopping their entry and reducing their accumulation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Secreted, cell wall.
Sequence:
MDEPSQGGDQKLSAMEHVKKRHEEKGFLYACLFMLCCCFCCYETCEHCLECFCCCCKKDN
The following text describes a protein:
Function:
The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme.
Sequence:
MNRWENIQLTHENRLAPRAYFFSYDSVAQARTFARETSSLFLPLSGQWNFHFFDHPLQVPEAFTSELMADWGHITVPAMWQMEGHGKLQYTDEGFPFPIDVPFVPSDNPTGAYQRIFTLSDGWQGKQTLIKFDGVETYFEVYVNGQYVGFSKGSRLTAEFDISAMVKTGDNLLCVRVMQWADSTYVEDQDMWWSAGIFRDVYLVGKHLTHINDFTVRTDFDEAYCDATLSCEVVLENLAASPVVTTLEYTLFDGERVVHSSAIDHLAIEKLTSASFAFTVEQPQQWSAESPYLYHLVMTLKDANGNVLEVVPQRVGFRDIKVRDGLFWINNRYVMLHGVNRHDNDHRKGRAVGMDRVEKDLQLMKQHNINSVRTAHYPNDPRFYELCDIYGLFVMAETDVESHGFANVGDISRITDDPQWEKVYVERIVRHIHAQKNHPSIIIWSLGNESGYGCNIRAMYHAAKALDDTRLVHYEEDRDAEVVDIISTMYTRVPLMNEFGEYPHPKPRIICEYAHAMGNGPGGLTEYQNVFYKHDCIQGHYVWEWCDHGIQAQDDHGNVWYKFGGDYGDYPNNYNFCLDGLIYSDQTPGPGLKEYKQVIAPVKIHARDLTRGELKVENKLWFTTLDDYTLHAEVRAEGETLATQQIKLRDVAPNSEAPLQITLPQLDAREAFLNITVTKDSRTRYSEAGHPIATYQFPLKENTAQPVPFAPNNARPLTLEDDRLSCTVRGYNFAITFSKMSGKPTSWQVNGESLLTREPKINFFKPMIDNHKQEYEGLWQPNHLQIMQEHLRDFAVEQSDGEVLIISRTVIAPPVFDFGMRCTYIWRIAADGQVNVALSGERYGDYPHIIPCIGFTMGINGEYDQVAYYGRGPGENYADSQQANIIDIWRSTVDAMFENYPFPQNNGNRQHVRWTALTNRHGNGLLVVPQRPINFSAWHYTQENIHAAQHCNELQRSDDITLNLDHQLLGLGSNSWGSEVLDSWRVWFRDFSYGFTLLPVSGGEATAQSLASYEFGAGFFSTNLHSENKQ
The following text describes a protein:
Function:
Some isolated peptides of this protein are able to bind to human U937 monocytoblastic and A549 epithelial cell lines.
Miscellaneous:
MISCELLANEOUS: Has been detected by antibody binding and Western blot in the cell wall fraction but no signal sequence is predicted by bioinformatic programs.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI
The following text describes a protein:
Function:
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1.
Subcellular Localization:
Nucleus. Nucleus membrane. Cytoplasm, cytosol.
Sequence:
MPYVLISTQIRMETGPTIVGDEFSDLVLMAQLEADKRTVLGNNFSEYYVNEPPRVTLNKLERLGYRVVSMTGVGQTLVWCLHKE
The following text describes a protein:
Function:
Loosely associated component of the core of photosystem II (PSII), it is not always seen in crystals. PSII is a light-driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating a proton gradient subsequently used for ATP formation (By similarity). PsbY-1 and -2 are manganese-binding polypeptides with L-arginine metabolizing enzyme activity. They are a component of the core of photosystem II. They have also a minor catalase-like activity since they cause evolution of oxygen from hydrogen peroxide in a reaction stimulated by manganese.
Miscellaneous:
MISCELLANEOUS: The central hydrophobic segment (residues 130-150) does not form a membrane-spanning region but could serve as a targeting signal for processing of the precursor in the thylakoid membrane.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Imports into spinach thylakoid membranes.
Sequence:
MAATMATTMAVLNTKCLTLNTNKTTSTSPKPTSKPISLSPLGLSNSKLPMGLSPIITAPAIAGAVFATLGSVDPAFAVQQLADIAAEAGTSDNRGLALLLPIIPALGWVLFNILQPALNQINKMRNEKKAFIVGLGLSGLATSGLLLATPEAQAASEEIARGSDNRGTLLLLVVLPAIGWVLFNILQPALNQLNKMRSQ
The following text describes a protein:
Function:
Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (By similarity). May play a role in lysosomal ion flux and osmoregulation (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Lysosome membrane.
Sequence:
MANEHSPLLVHGVYSMMGNAEDSRGGSAGTGEASNPKTDPRKLNTFFGVMVPTILSMFSIVLFLRTGFVVGHAGLLHGLLMLFVAYFIISLTILSICAISTNGAVEGGGAYFMISRSLGPEFGGSIGLMFYLAKVCACGVYVLGLVEAIMDVFGQDPGSSVAQGLRVLPQGYWYTVLYSSVVLLLCMLVCLVGAHIYAKASFLILLVVTVSLISIIISPLIVSPQGFNITHTYGNNHSVTVSPSYTGFNSTTLKNNLGPRYSLDYSTNTMMSFATVFAVMFTSCTGIMAGANMSGELKNPSESIPKGTIMAVAYTFTVYVLLYLLLSSTCDRSLLLNDYAVFQRVNVWPPFVTIGVYCASLSAAMCSMIGASRILHALALDQLFGLPLAPAAVTSSSGNPWVSVLYTWALVQCTLFAGQLNVIAGIVTVFYLLAYAAVDLACLALEWASAPNFRPTFQFFSWHTCLLGIISCVVMMFVINPVYSSASIVLLLLLLLFLHYRSPTSSWGYISQALIFHQVRKYLLMLDSRKDHVKFWRPQVLLMVSNPRSSCQLICFVNQLKKGGLFVLGHVQIGDLDVLPADPVQPQYNFWLSLVDKLGVKAFVDLTLSPSVRQGTQHLLRITGLGGMKPNTLVLGFYDNSYPEDYFLQDPVFCKGDRSEGDNFGVDLPSLQAHFPPVRHAESPRALQPQEYVSIIQDAIKMGKNICLARYFFQLPPESKGATYMWGKDSMDTIDVWPTNLLTPGSASYADVGSLFLLQMACVLNMASGWRRARLRIFVCVESESEDQGWLAKEEQFRELLGKLRIRAAIKIVAWDNVARMVRGPNTESQPVSEDFLCAVNGLLKEHSSTAAVRFLYLPDPPSSCELSQQYLTQLDTLTRDLGPTLLIHGVTPVTCTEL
The following text describes a protein:
Function:
Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MNVLPLSLLNAAQGQPMLVELKSGESLRGHLLKCDHWMNLTLKEVEEFSASGENTATVSEYYVRGSNIKALQLPDELLHSIKQQYSQQREQRQRQQQLEQGGQFGNRRGNRNYNNQSNNPNQRQRGGGRRY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDYQQKPPQSSDPSPSPPDRPPGIRSPETPSNNQNNDIEDIMACVTALEAALLPCLPARELQAIDRSPHPSHQIDVERHARDFMEAAKKLQLYFMGLKREDRAPSRAESLKKDIAVMEEELKTKDELIKKHMRLFQESQKLVKEQIEKHRDELEKV
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSHSNALPNSPFRSPKKQRMEVIGPLNASRFSFSPVKTPPHGRAGLSSPEKRLVKDLDKSARKRANNSLYNRLMDEYSDTDDYLDEQDRILADRIIKQSRGEPDEVNYGSDVELEIDLTQQRRTRRREKKVVYSSDSSNEYEDTGMPEESSSEEEEADDDDGNVEFVYGPPKERKTSLSSSPPTVKPTVRRTKRGRPSKSELVSGQIKSIFHQDDVLFSTDRKTFTPTKPTAAKKPVSNYLTSIFDQNFDRSKVPSLSGIPKSTNTHEEKKTFVPLPIPTLDADGNITDKEYISKYFDGVDPAKFKEGRFVDEKVFYLEGPEGYFEQQTTRVKQSGNSLTALAPQIEYKDFARLVKLGDNLSFQRKRHLFELHKYIYHQWCFEMSQGFNLNFYGVGSKIDLLRDFATNYFGIWWENVVHADLPKVLVVNGFNPSINIKKLILEIASILLPNESYPKHIAGTVPFVVDYLNNHRSPCGSIGFHKPKILLIIHNLDGEVFRVDKTQTLLSQLMTLPEVWAMSSTDHINASLLWDSSKVKNLNFIWHNLTTYATYQRETSFRDVISLGKSKKFVGGLGAKYVLRSLTDNHRNLYRELLIAQLDKMEKAVPSASGRVGLKGNAKVAVDLKSLYNTCLDEFITSNEMNFRTFLKEYVEHKMCQLVKDPSGVEKVFIPFTYEEIQNIYKQEFDV
The following text describes a protein:
Function:
Involved in the catabolism of polyamines. Catalyzes the ATP-dependent gamma-glutamylation of polyamines. Substrates include putrescine, cadaverine, spermidine and spermine, with a preference for short-chain polyamine putrescine. No complementation of the L-glutamine auxotrophy of an E.coli glnA mutant. Together with GlnA3, enables survival of S.coelicolor under exposure to high local environmental polyamine concentrations, which is toxic to the cells.
Sequence:
MDKQQEFVIRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVYESDMIAKPDPSTFQVLPWRAEAPGTARMFCDILMPDGSPSFADPRYVLKRALARTSDLGFTFYTHPEIEFFLLKDKPVDGSVPTPADNSGYFDHTPQNIGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNVMTFRLVMKQVALEQGLQATFMPKPFSEYPGSGMHTHLSLFEGDRNAFYESGAEYQLSKVGRSFIAGLLRHAAEISAVTNQWVNSYKRIWGGTERTAGAGGEAPSYICWGHNNRSALVRVPMYKPGKTGSARVEVRSIDSGANPYLTYAVLLAAGLKGIEEGYELPPGAEDDVWALSDAERRALGIEPLPQNLGEALALMERSDLVAETLGEHVFDFFLRNKRQEWEEYRSQVTAFELRKSLPVL
The following text describes a protein:
Function:
Required for correct development of the embryonic midline glial cells which are necessary for the formation of distinct segmental commissures.
Miscellaneous:
MISCELLANEOUS: Member of the Halloween gene group.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MLAALIYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLVPGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSSSPIVPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPADCFPLVLTPREKIGPL
The following text describes a protein:
Function:
Required for cis-Golgi integrity and efficient ER to Golgi transport.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein.
Domain:
The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
Sequence:
MGLCKCPKRKVTNLFCFEHRVNVCEHCLVSNHNKCIVQSYLQWLQDSDYNPNCALCNIPLAEQETVRLVCYDVFHWACFNSLASRLPLHTAPAGYQCPTCQGPVFPPTNMASPIADVLKDRLSSVNWARAGLGLPLIEDPIGNTEEDSHDVTDYRDWSTFDAQEQSNAYASSSYSTPLIPPPAAAAPQENLAGPQKNGDPNAQGHAVVTFSTANTCDTATIHTASSPRKIYDTRDVAHSSVTQIDFDDDKYRRRPALSWFARILKNRSGAKRTSLTWKQRVFMLLLVGVLGFFTLIIIMAKLGRASASSDPNLDPLLNPNIRVGKN
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLSRAIGRSLQTPALRNTSTNFRIASSTSWTRSMASNNRQPKKPTEYNRSSGTPKPSGSGGAQAAFTSQKPGQSSDKSGNPDFSKAQDEVSKDASPERNTVPESVGGGAGVPNPDARKGESSDFSGKQDEFETIAVDPAQAETENKPLPDLTQGIPSTLDFELANRKSKTSPLNLTEAADPEEIPGAGGKGRGELPASAYVSSSERKRNQMANYMYLAFFVSAITGTVYLGRNWETEEEEKLHAETAPSGWSLSGMWNRVRARTGDQIGHYTEPAFTKLLPDPTPMFERPYTLVLSMEDLLIHSEWSREHGWRLAKRPGVDYFLRYLSQYYELVIFTTQPSTLAEPVIRKFDPYHIVTWPLFREATLYENGEYIKDLSYLNRDLSKVILIDTKPHHAKKQPENAIILKPWTGDVKDKELVSLIPFLEYIPTMQYADVRKAIKSFEGTHIPTEFAKREATARKKFQEQLAEERKKHGKRGGGVGLLGNALGIKPGGMMVTDPNEQSLADALAQGKMLQDLARERGQKNYEAFEKEIRENGAKWLKEEAEMEEKAKEEGLKAMKSGMTGGWWGGASS
The following text describes a protein:
Function:
Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain.
Subcellular Localization:
Secreted.
Sequence:
MRFAFDSNHSQSGAPFKGSRCFFNCQCICCRQGCCVVVVKCCCCFNLNCCNSLGSRKSFPQPAAMRKKVADLEVLRVSRFVAVILVLARWVTAVATLLTSCILLDIFSVPGQSGVADRSQASSRTVHVSVPTTPNETPSSTSETKLKLLYGYTSYDINNDQQVKSNNLCRVLCKSRNRKRQRRRRRRRNHRRRRHRYTKRLHHLMQDNMSGFEQRLNFSDAKCQSLETNYGTNYDLVQGGKLFSQSERSLLVSPLREIEAPWPAIHGSMRNCSKIKRNRANLIWLLIGLVWFEVKLINCNGISSSNYYASNLESHKGCTLCHESGKPNIYTDKDNPHTDYNIYNKYHSNNNFNKKTNQPHNNIAPSDEVRLESIKRQILTKLGLSHKPNVSHPLPKQFIWETIYRVDGGRMIPNNAFGSSGKNLDQKTIKLRAFASPGSHLFNGRGGRTDQRSERDPSHHKYRSPFDFTFNISKNNVYGKVLRNRSLERIDKKNSFLNGWTENRQLKINSQIASMPIELKSHHNSSPKELKSGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIKRDLPKMVVDECGCP
The following text describes a protein:
Function:
Microtubule-based anterograde translocator for membranous organelles.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTPGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFLDCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAIFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPPSTVHASMASAPLHPATVVDHD
The following text describes a protein:
Function:
Acts as an osmosensitive calcium-permeable cation channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes to the cell tip and the barrier septum.
Sequence:
MVIEKRESFIEVVINSLLNDNPAQAKFDKYSILVSLGFSSLLSVILLCIFTLLRTKFNTYDRCIPPMKKSLWGWIEPLWSIKVEDCLYNMGADAVISLLFSRFCRDVFLILAAICCTILIPINIVATNKTLANSDSQNAYAKLSIQNVTGNWTWAHVVICYVFNVLVLFLLARYYQIVMRIRQRYYRSPTYQQSMSSRSLLIMDIPTTMRSNNGLSILASRLKSSEAPMHVHICHAIKNLPKILKKHDNAVRSLEAVLAKFFKNPKKLPDDRPVRRVKQGLLTSEKVDAIDYYSAKIENYGLRVDAARESLYENEFEHYGFITYKSSYIAHDTARHNSRVAGASVSMAPEPSDFLWDNLSLAWSTRLFNRMIGNILFIILIIAWIIETALVAIFISNLYHLGSVWPWLQQQLTSRSGFWSIVQGILSPAVAGFTFMILEIIMRRISYWQGSFTKSSRERGVLNKLHIIFTLDNFIIYTLMAVFWRLGVIIAYKTKEEGNFAEGMSAFATFDTVGLSVSSFVQFSTFWIMFIAHSTCSFFVEIAQPITLTIRLIKTKFFSPTPRDLLEWTAPTKYVYSQVLNKLIYFFTIAICYACINPLVLLFASVLFCVNYLTQKYILMYVSNSSTESGGGYWRPVVNRILLGLELANIILFLCLWVQGGRVRAYCIIPNFSFAIAFKIWCMFALDPKSHYMIEDPYMKVVEPLENEISESEMCFGHPSTYAPLLVPMVRSDARALLPLFYSGRTETHNKFDFATDSDDASEKHLRGEEEPLENVDFVDIDNVDTAKEVHDQQQVQQLKKNLSRSYTRSRGVSLRARLNEEELPLTESITQDSQISIPETLESQSTEITPINVSEHYDKYYHIF