lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTDPLLDSHPANSTGEMDGLCPELLLIPPPLSNRGILGPVQSPCPSGDPAPIPTEPGCLLVEATATEEGPGNMEIIVETVAGTLTPGAPGETPAPKLPPGEREPSQEAGTPLPGQETAEEENIEKEEKSDTQDSQKAVDKGQGAQRLEGDVASGTESLFKTHMCPECKRCFKKRTHLVEHLHLHFPDPSLQCPNCQKFFTSKSKLKTHLLRELGEKAHHCPLCHYSAVERNALNRHMASMHEDISNFYSDTYACPVCREEFRLSQALKEHLKSHTAAAAAEPLPLRCFQEGCSYAAPDRKAFIKHLKETHGVRAVECRHHSCPMLFATAEAMEAHHKSHYAFHCPHCDFACSNKHLFRKHKKQGHPGSEELRCTFCPFATFNPVAYQDHVGKMHAHEKIHQCPECNFATAHKRVLIRHMLLHTGEKPHKCELCDFTCRDVSYLSKHMLTHSNTKDYMCTECGYVTKWKHYLRVHMRKHAGDLRYQCNQCSYRCHRADQLSSHKLRHQGKSLMCEVCAFACKRKYELQKHMASQHHPGTPAPLYPCHYCSYQSRHKQAVLSHENCKHTRLREFHCALCDYRTFSNTTLLFHKRKAHGYVPGDQAWQLRYASQEPEGAMQGPTPSPDSEPSNQLSARPEGPGHEPGTVVDPSLDQALPEMSEEVNNGRQEGSEAPHGGDLGGSPSPAEVEEGSCTLHLEALGVELESVTEPPLEEVTETAPMEFRPLGLEGPDGLVGPELSSFEGIGTSDLGAEENPLLEKPVSEPSTNPPSLEEAPNNWVGTFKTTPPAETAPLPLLPESESLLKALRRQDKEQAEALVLEGRVQMVVIQGEGRAFRCPHCPFITRREKALNLHSRTGCQGRREPLLCPECGASFKQQRGLSTHLLKKCPVLLRKNKGLPRPDSPIPLQPVLPGTQASEDTESGKPPPAPQEAELLLPKDASLELPREPEETEEPLATVSGSPVPPAGNSLPTEAPKKHCFDPVPPAGNSSPTEAPKKHHLDPVPPAGNSSPTEALKKHRFEQGKFHCNSCPFLCSRLSSITSHVAEGCRGGRGGGGKRGTPQTQPDVSPLSNGDSAPPKNGSTESSSGDGDTVLVQKQKGARFSCPTCPFSCQQERALRTHQIRGCPLEKSGELHCSLCPFTAPAAAALRLHQKRRHPTAAPARGPRPHLQCGDCGFTCKQSRCMQQHRRLKHEGVKPHQCPFCDFSTTRRYRLEAHQSRHTGIGRIPCSSCPQTFGTNSKLRLHRLRVHDKTPTHFCPLCDYSGYLRHDITRHVNSCHQGTPAFACSQCEAQFSSETALKQHGLRRHPEPAQPAPGSPAETTEGPLHCSRCGLLCPSPASLRGHTRKQHPRLECGACQEAFPSRPALDEHRRQQHFSHRCQLCDFAARERVGLVKHYLEQHEETSAAVAASDGDGDAGQPPLHCPFCDFTCRHQLVLDHHVKGHGGTRLYKCTDCAYSTKNRQKITWHSRIHTGEKPYHCHLCPYACADPSRLKYHMRIHKEERKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQCPECEYCTNRADALRVHQETRHREARAFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHRAFRWAAGLRHHALTHTDRHPFFCRLCNYKAKQKFQVVKHVRRHHPDQADPNQGVGKDPTTPTVHLHDVQLEDPSPPAPAAPHTGPEG
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
MPKHEFSVDMTCEGCSNAVSRVLNKLGGVEFDTDLPNKKVSINSEHSVDILLGTLEKTGKAVSYLGPK
The following text describes a protein:
Function:
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.
Sequence:
MKERRAPQPVVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIFRTASMMAMVRAWKETGMGRGKSQARLEDLTLRKNHHTPSQALGCGEGGCPSVSPPAPAPEEGKVWGCGGHAGLMGLGAYGSLTFSIMPLPHSASMWARGWEGSPSPSLPF
The following text describes a protein:
Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGKAKEEERMVIGGALRALLISARSLRSEEVVDLAAPRSWESEMEGCVSNLMICNLAYSGKLEELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVES
The following text describes a protein:
Function:
Involved in pre-mRNA splicing; specifically in the final stages of spliceosome maturation. Promotes the first step of splicing.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSKFSLKLGSKTLKKNISKKTKKKNSLQKANLFDWDDAETASLSHKPQSKIKIQSIDKFDLDEESSSKKKLVIKLSENADTKKNDAPLVEYVTEKEYNEVPVEEFGDALLRGMGWESDSEQDSKGDKTQSRNKDVSNVSQIHPDGLGIGAKLNKAINVEEASFMPVVKIDKITGTKVDDDKKNKS
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFDFSIVTNWIHEMLLSVMPEGWAIFIECIAVGVCIVALYAILAIVLIYMERKVCGFFQCRLGPNRVGKWGSIQVICDVLKMLTKEIFTPKDADRFLYNLAPFMVIIASFLTFACIPFNKGAEILNFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIGAMRSGAQIISYELSVGMSIMTMVVLMGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAGNAECNRGPFDLPEAESELTAGYHTEYSGMHFGFFYLAEYLNLFIVASVAATIFLGGWMPLHIIGLDGFNAVMDYIPGFIWFFAKAFFVVFLLMWIKWTFPRLRIDQILNLEWKYLVPISMVNLLLMACCVAFGFHF
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MEYKRSSHVEEDDDMEEEDEMEEDDDEEEEEEEDEEEEMKGRHHHHHQHHYAAAAPAATGGAPPPHQHAHGHVLVSSAAASSPSSLLESAAFSRPLLPPNSSLISSPPGFLSPHDHHHHQQQQQPHRRRGERERERTVESTGEQQRQRQQEPARNGVLGGGSGGPMPPPAAPAALALVTGGSAAAAGEPLPWRYRECLRNHAARLGAHVLDGCGEFMPSSAPGEGSAAAAALACAACGCHRSFHRREPVVAAASPSPSPASAVVSPSATPRAGAGAGANPNSRLIPLLLAPPHMQQQKRPPVVVPGSSPMSAPAALAVAESSSEELPRPPPQQQHPPHAQAAAMAGSASAPAAPGKKRFRTKFTPEQKDRMLEFAHRVGWRIHKPDGGAVDAFCDQVGVSRRVLKVWMHNNKHLAKTSPSPSQPLPPLHHDPPPAPHHHHHHPAQHHQQHDA
The following text describes a protein:
Function:
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin (By similarity).
Subcellular Localization:
Secreted, extracellular space. Mitochondrion.
Domain:
The olfactomedin-like domain is involved in the interaction with cadherin.
Sequence:
MSYSLLFLLALQFCLGSASRTTLTSAHSRELTTPPTSPQATAAWLPPGGTSWAEGGTVSQPLSNFTGSVDSHGTCQCSVSLPDTAFPADRVERLEYTAHILSQKFEREFSKVKEYVQLISVYEKRLLNLTVRVEVMEKDSISYTELDFELIKLEVKEMQKLVLQLKKNFVGSTHIIDMLEVEIRNMTLLVEKLESLDQNNVLSIRRQILALKTKLKECEASKSDLVPATPPPPAPGSCSHGGVVNISAPSVIQLNWLGFSYKYGAWGRDYSPQHPERTLYWVAPLNTDARALEYYRLYDSLDNLLIYSHFRDYRIRYGQGGGTVAFNNNLYVNWYNGGNIAKINLTTNVVDVNRPLPLAAYNNRFSYANVNWQDIDLAVDEQALWAIYATEASTGNIVISKLNDTTLEVISTWVTKQYKPSVSNAFMVCGVLYATRTLNTKTEEIFYYYDTNTEREGNLGITMRKMQERIQSINYHPFDQKLYVYNDGYLLNYDLVFLQTPRQPV
The following text describes a protein:
Function:
Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTQTKAATTGWQRLGRRILYTSFRTHLLISALLRIALICYGQLHDSQSAVPYTDIDYKVVTDGARQVLAGDTPFARHTYRYSPIMAYLQTFNILLHPAWGKLLYATFDLLIATLIYRLVHMEIKSQYQKTVQHLLSKFNRPRDSDQSLDALDERSHPENLARASACFWLYNPLTAVISTRGSGDCFSSFFVILTIYLLLKSEHNVTRSYWLIFGAGLAHGLVIHLRLYPLLFSLAYYLSLSTRLTQTPLDFLCQILRPNKQQLCLISGTLISLVAFTWTFYTMYGWEYIYEAYLYHFVRKDPRHNFSLQFLLQYLGSASSVAEPSAILKTLVLAPQFLLILYLSLSFGQFRQTLPFCIFAVAFVIVTYNSVVTSQYFIWYLAILPLCLNNFKMLSWRRCFGLLFLWLLAQALWLLPAYLLEFHTWNTFYWIGLQGAVFFATNGYILEQLLSHYGFTQFKISYRKLL
The following text describes a protein:
Function:
May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
Miscellaneous:
MISCELLANEOUS: Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage; MISCELLANEOUS: [Isoform 2]: Major isoform.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Synaptic cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cell surface. Secreted. Note=Partially enriched in lipid rafts (By similarity). Also detected in the endoplasmic reticulum and the Golgi.
Sequence:
MGRAGGGGPDWGPPPVLLLLGVTLVLTAGAVPARETGSAIEAEELVRSSLAWESRANDTREEAGLPAAGEDETSWTERGSEMAAVGPGVGPEEALEASAAVTGTAWLEADGPGLGGVTAEAGSGDAQTLPATLQAPDEALGSSTMPPAIPEATETSGPPSPAVHDKPSVGPELPKEIPLEVRLNLGGSTPEPTFPLQGTLETQPASDIIDIDYFEGLDSEGRGADMGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLEEEEEEEEDKDTVGGGDLEDENDLLLPSQKPGVGPGTGQPTNRWHAVPPQHTLGMVPGSSISLRPRPGDPGKDLASGENGTECRVGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKFCDTPRVSSPHARALAHYDNIVCQDDPSAPHKIQDPLKSRLKEEESFNIQNSMSPKLEGGKGDQDDLGVNCLQNNLT
The following text describes a protein:
Function:
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Sequence:
MDYRFGRQYRLLKTDDFSSVFAFRNRRSRDLLQVSRSNGNGLGHPRIGLVVGKKTAKRANERNYMKRVIRDWFRLNKNRLPPQDFVVRVHRKFDRATAKQARAELAQLMFGNPATGCRKQA
The following text describes a protein:
Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells (By similarity). Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (By similarity). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Sequence:
MAQRHLWIWFLCLQTWSEAAGKDADPMVMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYKADINEENEETITKIYYLHIYRRLKTPKITQSLISSLNNTCNITLTCSVEKEEKDVTYSWSPFGEKSNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTVQQPCTDTPSFHPRHAVLPGGLAVLFLLILIPMLAFLFRLYKRRRDRIVLEADDVSKKTVYAVVSRNAQPTESRIYDEIPQSKMLSCKEDPVTTIYSSVQLSEKMKETNMKDRSLPKALGNEIVV
The following text describes a protein:
Function:
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTENCESEKPSKIAKLDDITNDEFVSKISPSFETFEGFQVKRILKESPESRSIVVEGSFSGDNSVASVSSSIVILEKTHFTEKEVHGILTKSTALQCLFNNDVYYNFLCHPPIQLNEVKATLIHPASEKHIEKFSTRKSFLIEETALIYQSVTLLHIRESKFDLQWVYNILEHKKEADRIVYEDLDPDCGFILLPDLKWDCRSTSNLYLTGIVCKRDIKSIRDLTSEHLPLLKNIFDKGSASITKKYGLDKSEQRIYLHYQPSYYHLHIHFTSLQFTPPGCNVERAHLLSNVIRNIELKSSYYQESSLDFLAFEGDPLLKKYHQYIGLSSDGDY
The following text describes a protein:
Function:
Induces a small but significant sodium conductance when expressed in Xenopus oocytes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGSCSCTRRHFLLSICFLQVITIIERQVFDFLGYMWAPILVNFFHILFIIFGFYGAYHFRVKYIITYLIWNFLWIGWNTFLICFYLNVGQLNRDSDLLNLGTGSVSWFEANGYGCKPTYNMAADDTFRPQRPERVEGCLLDYPLVEITHSGVQCALALLGILGAILISCIFLDEDDRFDFMNGDAKSPQHTVVHPMYVSYTSIPTTSASATMQSNKHLQLQHQQPQQNSLKLYHHQQQQQPKLHHFNKNYQLSGSNNNTLNNNLHQRAPALLPPNTTNNRSASFQTQSHPSNNHVTQRTGGEGSNCSSLRRHRQHHSKALVSPSPMSPQTTPSLSYASLQNSSPYLAGNSLSNSNYSIFQSPDSLQGSSHFARIHHKPKPPKSDYPVSGEFNPGGNISSPVRPLDRLSRSLEDDEDNFSLQKFAPGEHGVTYVPFQSPTPNSLFLGENNNSQPHLVFHTNSRSSPNNNAYPYDQSGLPSSLRMGSNSNARRPTHIPLPTVPMHNCQEVENDEDADGESEQDHDQMLTPPPPPLVRPHIHQRLGQAPYLDLSPEVAERYAIPSKLGPSLPIQVPLPVPHGSPMVRRSNRRPRPSNPVNFCDQIRATPPGYVVRAQSDDRLMEQVEADAAPHVNRRSGRGGSGQKTRPRSFCNSIVGVQG
The following text describes a protein:
Function:
Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity (By similarity).
Sequence:
MAQGSPATVAACAFCGARRTRSGMVLSTSAADGYLDDEAQFETALRLLPAADQAAVRRRRAGRAVVLASRLLRTLGCAVHTGCAPALLAFDYSRAGKPYLRSRPAPAFSVSRSDCIAVIYVREGGAVGADLASVAECLSWAPDEILQLHDVFSAAELGRLRAAAPGRARAELFAYYWSLKEAYGKFRGTGLAGDLRLADMGELDPLRRGELRTLRRTLQGKHVCLSSRWHDAGHVLSLCEAREPSPTEEICLHKVPMEEVVRLCRPSLGMEKCHVR
The following text describes a protein:
Function:
Dispensable for transformability.
Sequence:
MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYNGSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCCKSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGLIGKLADAGLAEEELKKIHEQANTLFTSYV
The following text describes a protein:
Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
SPGAAPAPGPLIEPPSDPAGAEREPYWADLQPRAALVERGGSLWLNCSTNCPRPKRGGLDTSLRRAGGQRGPRWLSRELVDIREPESRPVCSFQCGPRLLQARGVIRTFRPPERVELTPPPAWVPVGENYTVDCRVPEAVPLENLTVALVQGTRELGRQGFPGKPPDTQNATATFTVLARREDHGTDVSCQAQLDLRRLGLELFRGRSASVRLHTFREHRSPALSDSWLLEVGAATSVSCEAEVFPAGEAQVHLSLGGRERNPTVTRDGDRLTAEATVQAEEGPEQELDVNCTVAVGSESRTAHKTLTVYNFPPPELTLSEQSPVEKTPVNVSCRARPGASVKLEGQPEPPGGEPAHLQLIAREEDNGRLLTCEATLSLKSVRLVKRQNVQLHVLREYGPRMNASDCPGNWTWLEGTEQVLRCRARGNPTPTVQCVHAGIKDAFLPESPLRVTRAHAGTYRCTASSQLGTEARDVVVTVDYVELSGPGGSRHPLGAVFGLGPVQLSTCLVEPPRANRGHRGTCRCDAVNACGSASREREWEVQEEFGSPSARAWVEPTGWPFTCEAERDPAPAMVCVGPGSGGPGIPWLGSPHPQPLLSPAPNPMSWASIIATGERAPPWMDETSCPSHQTWLEGVRGPALTCGAWGTPPPRVQCARDGDLKRLEGLEEPEWPERGRSVSREDAGTYRCEATNARGSDARMVTVGVEYRPVVALLAATPSGRVEPGGNFTLTCRADGSPPAQLSWHTPSGARGFGLSLSGDNGTLSVAGAHGRHGGVYECMATNAHGHHVRRITVRVAGPWPWVAGGGAAGGAALLAGLAALVWYIKSAACKTGEYSVQEAESAGQAVGAGTEAGDEIYAIQLTAK
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MKNLTPLEEALKIVLENVKPLESERVFIHEALGRVLAEDVVSDTDKPLFDNSAMDGYAVRWEDIKEVPAKLKVIGEYAAGTGENLKVEKGTAVKIFTGAPIPEGADTVVPVEYTETQDGYVIVKKSFKQGANVRRRGEDVKKGEVVIPKGKEIRPYEMGMLASVNRAVVSVYRKPHVGILSTGDEILDVCEEQTKPSQIRTSNNYTVYGQVLQAGGIPHNLGIAPDEPQKLKEIMRSIHKYDIFITTGGVSMGEKDYVQYLVEDLGIDVKFHKLRIKPAKPVLFGVYGENKLFFGLPGNPVSAAVAFDLLVYPAIKAMQGHREVFKQKVTAILEGDYRRKNADRREFARCRVWFENGRYHCEPYPKQDSHMLTSLVNSNAYMVVYEGVNELKKGQEVEVILF
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MPRWPEQGPPSATLPPMPESPVPLEFTADPGRLDAVVSLLSGVSRSQVAGWIEAGLVEIDGRAASKASQKLRGGEALRVSPPPLPSAQVEPEDVPLDVIFEDEHLIAINKPPGMVTHPAPGVISGTLVNALLGRMSLPEQQDFDGPDGYRPGIVHRLDKDTSGVIVVAKTVAAHARLAAAFKDRETKKTYLAIAAGAWKAERPVQVDAPIGRHQIQRQRMTVGGAGAREAQTLFTPLDAHPDGHGRTLALVRAQPRTGRTHQIRVHLAHLGSPILGDAVYGRASEIMPRHALHAQFLEVPHPVSGDILHLQAAVPEDLLGAWVGLGGRWDPAWEQAPQ
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Sequence:
MAAAPPPSIYTESFNTSSNNNIQNEVNDNDRDTILSGFSFDEYFLVNESISVIKENNFKQIALQLPDYLLWASSELSNKIQKSVPQEYGIKVFILGDTSYGSCCVDEVTSSHLKADFIIHYGHSCLSPEILAEQFKNNENIKVSNINTFNNIYLTKSFKNNNNNNNSISNENCGVSDCCSSNNNNNDGCCGNTKNNDSSCCNSNSNSCKNNNNNNNINNNNIDNNEKNNLISGRIVDLNENDDIKNYSFVWIGDESLTLTNILLNFNQQSIYRYYIDNNKIAQETLPRNKSLMRRYHISEKCKDASVIGIVVSTLSVAKYSETIDGLKKLIISSGKKPYVFVVGRLNVPKLANFSEIDIYVIVACSENTMVDSKDFYKPIATPFELNLALRNEQWTGEYVTDFGKVFPKLLEEKLESTREKPEDEVEDDEGNIHHFSLVTGRIVLQNKSTQQQEQQSTSGEIVSVDNSFKQISLVENHLQNKTYKGLDMRIGETPVTAAIEGLSGIPKNYTSEKNNLNK
The following text describes a protein:
Function:
Catalyzes the oxidation of glycolate to glyoxylate, with a reduction of O2 to H2O2. Is a key enzyme in photorespiration in green plants.
Subcellular Localization:
Peroxisome.
Sequence:
MALVTNVCEYEELAKHKLPKMVYDFYAVDAEDQWTLRENSEAFSRILFQPVVLVDVSCIDMSMSVLGYNISMPIMIAPTALHKLAHPEGELATARAAAAAETIMTLSSWSSCSIEEVNLAGPGVRFFQLSIYKDRNLVQQLIQRAEKAGYKAIVLTVDAPWLGRREADVKNRFTLPQNVMLKIFEGLDQGKIDETNGSGLAAYVASQIDRSFSWKDIKWLQTVTSLPVLVKGIITAQDTRIAIEYGAAGIIMSNHGGRQLDYLPATISCLEEVVREANGRVPVFIDSGFRRGTDVFKALALGASGVFIGRPVLFSLAIDGEAGVRNALRMLRDELEITMALSGCTSVKEITRGHVVTESDRIRRCSRL
The following text describes a protein:
Function:
Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, secretory vesicle, acrosome lumen. Note=Localized in perinuclear pro-acrosomal granules in round spermatides. Localized between the inner and outer acrosomal membranes (matrix or lumen) in spermatozoa. Secreted during acrosome exocytosis.
Sequence:
MAVSQGDGTLCFVLLLCCWQETELRPRTVIPGSPTEIPFSSKQEDMSELLDEILVQEILDLNKTTPSEMPSTASTLSTPLHAGIDENYQAGGSENYHELLENLQFSPGIEVKISNDEANANANLHGDPSENYRGPQVSPGSEKSVSSKEKNSKNTQYENLSILDQILQNIGRSSGNIFHKEQQRTSAQRRSQGSQ
The following text describes a protein:
Function:
Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.
Sequence:
MSSWQILPDADNNYRWQINSDDTSNVIPPSPPPFSIPTPPLPSMYDLLIHASASHLFQPQEEENAIDDSFGFANSLFKTGSGRKVTISSKGLVRAKTLLGLGLHEETVGANIQTPQNAKKFNSFHQDEPRLQVIDSCKKTSAASFQSPLVSRLKNGFENKIVQPDTGSRSGVGAKQAPIKFQTGVSNIQAPQTQNASFFDAFDEELPDLQLMDSCKKMSAASFQSPLVGRLHMGSENKVAQLDSGSVSGGKDAPLTNSLFKTGSGRKVTISSKGLVRAKTLLGLGLHEETVGANIQTPQNAEKLHAFDEELPHVQLMDSCKMMSSASFQSPLVGRLKNGFESKFVQPDSGGGAKQAPIKFQTASGRSLSISGDALKRARRLLGDPDLGDFFDGGDSLFSFLDQGQTSTITSSAERSESKNTHTPLVHQMTPENHPNHMSKSFTYPLQPSKQMEFSNKLRNEGNGNNLIVKFDDVVNESDCGCKSSITPGQKPLYNKNEVADTTIKSSSLNGFSSRMDSREKPLGRALVDISNTIKTVHTNHKQPASGKRRIGLHATVSSFKKPRISNISASGGQDVQYFSNDLAQLSSGASGFKRKVSTRYPFHHPRMYIKDYFAVPPLEQKVVSVISNFPNPARQVTSCNAGAYIFHDGSDSNDMGAEAFIHLLTQHGASLRFASKEWVLNHYKWIVWKLACYERCYPARCAGKFLTVSNVLEELKYRYEREVNHGHRSTIKKILEGDGLPSSMMTLCISSIHSDHVLDSGALSEPQTGNQSNEALKVELTDGWYSINAILDVPLSKQLAAGRLFVGQKLRIWGAGLCGWNGPVSPLEVSSTVSLLLHINGTYRAHWADRLGLCKVAGPPLAFKCIKRNGGLVPQTLAGITRIYPILYKERLSSGRSVVISERMENKMMELHNQRRSAVVDNIVSEYQKEMTGSHIYDYGNSEGAKIYKMLETAAEPEFLMADMTPEQLSSFAAYKAKLNANRQSQMESSIEKALKDSGLGDREVTPFMRLRVVGLTYKNQRDKPTEGIVTIWNPTQKQRQELSEGEAYAIAELIPSGSDSDVLHLQTRGSTTKWLPLSSNAKEQFKPFSNNRNSIPLSSLSDIPLSNEFDVVAFVVHVGKVYTSSQQKKQWVFVTDGSIMNGLQSQKVTDTLLAICFCSPLFDHDSFPPINHNLAGSTVGFCNLIKKEKDHTNHIWVADANEISTYYLKFDSPQCSHLRNAASSVRRWASNSSLIIEKLKEKVLGIVGDCKA
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably involved in the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNRRINRETIRNISSTTVLIALPVILFFGSFMIGRYPVSPLDVILAIVSVFVPMETNLDPTIYTVVWDIRLPRIIAAMIVGAALSISGASFQGTFQNPLVSPDILGVSSGAGFGAAIAILFSFSMVMIQTTAFLFGLLAVFLTYFLSKRFKGNTVLMMVLGGIAIAALFSALISCIKYLADPDSKLPEIVYWLMGSLSAVESSSILMIAGPVLVGFTALLLIGWRINVLSMSDDEARSLGINTEKMRLLIIFCCTLLTAAAVSISGIIGWVGLVIPHAARMIVGPDHRKLLPASISLGAAFLLLVDDVCRTATSIEIPLGILTAIIGAPFFVYLLQKGYEGWS
The following text describes a protein:
Function:
May be a regulator of keratinocyte proliferation or differentiation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLLFYHSLSSPGPLVSHCHSESSIHPHLTFFSISSPGSRELVPPSHFQARPPAAPSWARAGVQLEVLELRRENQQLRAAMWGWGGGRAAEQSQGLSQQAQLVSPQPQELPRLEAEAQQGAKLEAQAEELEALGRAEVEELRASLARAEEARLRLEEGGQQELEAARRQHEEEVTHLTQAHLEALSTLRGQVQELHETVQELEARRGQEAMALAAAQAEADTLQEQLKKSREELEARDSLVRQLRRHVSEQGVAQSRCQAWEQERGELQQAVKRLQEERAALSSTSELLQVRVQSLTDILTLQERELAQKAPNVNILEPESARKARALLSRWREKVFSLMVQLKAQELSHPRVPRQVAELEKEVASQRQQEALLLHSLKGKEAEIQMEQVNSKVSHGGGQKTPRGSGHAPLHPLSVSPPALDTELRQLREERSRQDAELRFSARLLQQEVARARDQGREERQRLAEASQRLERELRESREALGEAEARLEAALAGQRDSQDQAASLRRELGKQQEVYERVLQEKVSEVEARLREPLAALEKELSAARREHSKAVVSLRQVQRQAARDRERNLELRRLHEEARQEQEARTSRRLQQLERDKHLLLNTLRQEGLVSRYKQQRLTFLPRLLPASGEPTEPSVGPRPRTPPKGRRWSAGDSTPHSLLRPPPPPPPRLSLDASLRSPKFFLGAQGRAQGSSAPAGKSPGQGVRAAGSHPGSTTCLLCHLGSLAVPSSAKWGFKTHASLLLRLRAP
The following text describes a protein:
Function:
Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.
Sequence:
MPGAPGTSGRVRTAGGRRAVAGSPYGGCAGAGGNAGPVVASEPAAGTSTKAHTARVGAGQGRGLHEGAGQGSGMAGSGSGTGPGSGTGPGTGTGPGTGPGTGPGAGGRRSAPRRQAAREPAARTYARALPVVPVRARGLTIEGADGRRYLDCVSGAGTLALGHNHPVVLDAIRAVLDSGAPLHVMDLTTPVEDAFVTELLRTLPPGLADRARVRFCGPAGTAPVDAAVALARAATGRTRVVTVTDAVTVTDAVTDADADADETFLDDDHGGGPGRERPAGLLLEPVRSEAGVRPVPDGLVRRLRARAADRAVPLIVDETGTGVGRTGAYWAFEHSGVTPDVLVLAKAIGGSLPLAVVVHREDLVEPDRTAGAFRGNQLALAAGAATLAHVREHRLAEHAATLGGRMLTGLRALAAEFTCVGDVRGRGLMAGVELVAPDTAPDVAAHGARPGTAVRPGTAAHLATAVRRECLRRGLIVDVTGPRANVVRLLPPLIVTEEQMSAVLDRLTDAVRAVDRDRPGGSVPLRGKRGPR