lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for synaptic transmission regulation. It probably controls the recruitement of voltage-gated calcium channels to the presynaptic membrane, and modulates neurotransmitter release.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Preferentially expressed in the mitochondria in the presence of TSPO.
Domain:
The SH3 and proline-rich domain is required for the interaction with TSPO and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2.
Sequence:
MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAPPKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELPLQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQCPLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQASGRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIEYDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEPERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC
The following text describes a protein:
Function:
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Sequence:
MKDKLFQHHYLQQHQQQQHQKSLSDEVDSSKSSGENKKVKFDEQRERTGGDGSTIEVVKRPRGRPPGSKNKPKVPVVITREEEPSAVMRPHVLEIPAGHDVADSLARFSQRRNLGICVLSGIGAVANVTLRQPHLGLVPQPAGAPATIVFRGRFEILSITGTFLTPAMAEVSPAAASSLSISLAGPQAQIVGGTVAGPLVAAGTVVVVAAAFSNPTFHRLPAEDDVSASVSITGGGGGGGDMEDQDQHMYNQQQKQQAHRQRRHQVLATTASAAMAVGSSGMSVYSGGHVPSDVIWAPTARPPPPPPY
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MSEVGASYRIPLLRSKRDEASRIDASRKRKLLELFAVCDNEGPIPKISRIDPNAPPTTAAEAQFLEACDILQDRPFNESNLPNRRQLKFDSLKQISSVRQAGKDLSASDGPNKIEHYFKRDGIIPRKNRGSSPIENSNEGRNIEKNGNDVGATPGAAAVSMQRSSPKSSQIGLPRETSAELNTTVEETFKSASRPATAAQEVQPALTNKDFEIDRIKRVVESPPGSPGVDPRKAVPPSPEDVANLQEPVIFGANDENHHAATAHLPPKEVQEARLEEIEKARDHKGERRRQSIADPLRASVDLVSSPSSTIDAHSTTTPARHDASAGTSPENDNSRSGYLERPDDEIDGKIATESRSIREDVVQKDVHDRKQKAQNEISRTEVLGSSSISADAQLRMEDQAASGSIVPVVAEIADSQASSSQDVEEPKLLASEISNVEKEPTKDKNDVSADVLRRDKTRSENSHATPKMEEVPDSEGDGQTPQDAMDLDVATVKDSFESHTTLDSSAILNTKASAPAGEASTQPSSNTKSPPSTPAPITRKTSSTPAPVQVPIERMTTRVASGAIRHKSVSEILGETPAPNNSPTSIRSPTSKPDTGSAADSPSRGSTPGSTRSLLQKAKEKSQSRLSTVVFAKKPFGSRANDATMTTIGAHLQQAHPQDDYFACLYLNSHNTQKTGYPPLDGLLQTAHKTITTSNAFVPITENQTTRILKRIYGLQNNHKWSLRQPKRSEEPVRPTTHWDVLLQEAKWMRTDFREERKWKMAVAKNLAYACAEWVEASPEERKILQVNATRQPISLAEIPEDVEMGDATSQLLPRSTPELIPSAEADSPMDDVDEELRLTITDTVSPTAIFGLQDDDVVFGLSRSPATDKLLEELPLYGAPLSVPCNDLPTSKVDPDRFWRRPAVGISKYVEGRMELKFQGPPRKKSRFEYEEDSDDEDVAVDQSRRERSILPPEQTNIGLFDPANKHIRDRIHAGHQFRPPSEFPMPTQSFFECRQCSLWTFSEDEELERLVREYAYNWSLISNMLSSRSLQSSGAERRTPWECFERWIALEGLPADMQKTAYFKAYNNRLEAAQRNLQVMATQVPQQPTANGQPAAPRRRTTTSQRVEKRRNQKHLALVDAMRKLAKKRENSAQKQQLSAAQAAARKPAEQPQTWTPIKTPQEFSRLKHDRDEQLKKSMAAFQQRQEQVRREAQARQRNAAQQQAHPNGLPQQRGPALPNGLVPPISQPNGNGHLTIPGQNRPRPLPPHMGVTGPMPNNLRIPQAMSNGVPQAQMQGGLPLNPALTPELADGARRVSLQQRQQQMQNMTQQQGSPHPGQAQNSPSRMNGMPTQPGFMPNNMTSYNNNNINGMAGSPGISTPSPAQTSSPRVGLPPSGIPNGGLPPNIPYLEIERNVRRANPHASASEIHKLMGENITAFNNNKHLQQRGLVQPPSGIAASAMNAAAGNNNLGMNGQGGQRPPIGIENASPQMYAQMLSNHHQQRLQNSQQQQQQQQPSQATGSQNQGQGAQQNGGK
The following text describes a protein:
Function:
Encodes a member of the mid-SUN subfamily of SUN-domain proteins that is localized to both the nuclear envelope and the ER. It is involved in early seed development and nuclear morphology. [TAIR].
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MSTSNEENVGFCQPSDSMEKNLFNDIGSVTSDESLCTESTETGSSNDGLLGSEGNVNHAFASEKPEAISGSDSGPKTDRDRLSHSVPLGLDEFKSRAFSSKSKLGTDQAGGVIHRVEPGGKEYNYASASKGAKVLDFNKEAKGASNILGKDKDKYLRNPCSAEEKFVIIELSEETLVATIEIANFEHYSSNLKDFELLGSLVYPTDTWIRLGNFTAANVKLAQRFPLQEPQWVRYLKLNLLSHYGSEFYCTLSIVEVLGVDAVERMLEDLISVQNNVFVPKEETGDQKQLSSQTESTQVDDCDQELCMEMGSSSSVENSNVKHEVPKNKVPDPVDEIRQQQGGRMPGDSVLKILMQKVRSLDLSLSVLERYLEELNYRYGNIFKGFDKDLVEKDTLLEKVRSDIKNLYDSKELMAKDVEDLLSWKSLVSTQMDNLLKDNFALRSMVEGVQKNQISMENKGIAVFFICLIFGTLAFVRLLVDILL
The following text describes a protein:
Function:
Virulence factor that plays an important role in blocking phagosome-lysosome fusion and thus participates in the intracellular survival of the pathogen. Acts as a phosphatase that dephosphorylates phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents. Therefore, SapM eliminates PI3P from the phagosomal membrane by catalyzing its hydrolysis, and thus contributes to inhibition of phagosome maturation. Also interferes with autophagy: SapM blocks autophagosome-lysosome fusion in macrophages by binding to the small GTPase RAB7, which prevents RAB7 from being involved in this process and thus negatively regulates autophagy flux. In vitro, displays phosphatase activity with broad specificity; can dephosphorylate a variety of phosphoester substrates, with the highest activity against phosphoenolpyruvate, glycerophosphate, GTP, NADPH, phosphotyrosine and trehalose-6-phosphate. In contrast, the enzyme exhibits poor activity against glucose-6-phosphate, phosphothreonine, and a number of nucleotides (NADP, ATP, AMP, and GMP).
Subcellular Localization:
Secreted. Host cytoplasmic vesicle, host phagosome. Note=It remains to be determined how SapM, once secreted into the phagosomal lumen, gains access to PI3P within the cytofacial membrane leaflet. It is possible that SapM is exported to the cytosolic side, or alternatively there may be a mechanism for PI3P presentation to SapM remaining on the luminal side.
Domain:
The C-terminus of SapM is required for interaction with RAB7 and SapM-mediated autophagy block.
Sequence:
MLRGIQALSRPLTRVYRALAVIGVLAASLLASWVGAVPQVGLAASALPTFAHVVIVVEENRSQAAIIGNKSAPFINSLAANGAMMAQAFAETHPSEPNYLALFAGNTFGLTKNTCPVNGGALPNLGSELLSAGYTFMGFAEDLPAVGSTVCSAGKYARKHVPWVNFSNVPTTLSVPFSAFPKPQNYPGLPTVSFVIPNADNDMHDGSIAQGDAWLNRHLSAYANWAKTNNSLLVVTWDEDDGSSRNQIPTVFYGAHVRPGTYNETISHYNVLSTLEQIYGLPKTGYATNAPPITDIWGD
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Sequence:
METLHNALLKWYEEFGRKGLPFRNLKGINAPYEVYISEVMSQQTQINTVIERFYSPFLEAFPTLKDLANAQLEEVLLLWRGLGYYSRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGIGAYTANAILCFGFREKRACVDANIKRVLLRLFGLDPNIHAKDLQIKANEFLNLNESFNHNQALIDLGALICSPKPKCAICPFNPYCLGKNHLEKHTLKKKQEIIQEERYLGVVIQNNQIALEKIEQKLYLGMHHFPDLKENLECKLPFLGAIKHSHTKFKLHLNLYSAAIKDLKNPVRFYSLKDLETLPISSMTLKILNFLKQKNLFGG
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
MNVVTFSELRAQLKKILDLSADQHEPVVVKRPNKETMVILSLRDFEALKETAYLLSNEANAARLRQSIRSLKQGKAQKKKLMED
The following text describes a protein:
Function:
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Subcellular Localization:
Secreted.
Sequence:
MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD
The following text describes a protein:
Function:
Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTEVNDVASVNINIGILGHVDSGKTSLARALSSTASTAAFDKSPESQRRGITLDLGFSATCVPTEGIAPDLFNAGIQQVQCTFVDCPGHASLIRTVLGGAQIIDMMILVIDACKGIQTQTAECIVIGEVLCKPLVLVINKVDAIQGSTSEEKRAAIDKLRKRLQKTFERTRWPSVAMVEVAAAPRREESGGTTCEGCMMSPINVEKVLPAVLSLVDADTIKRNKEAPLRPEDFVMMVDHCFALKGQGTVFTGTILRGQVSVGDSVVIPESHVVKKVKGLQVFRKPVQMARRGDRVGLSVVQFDAEGMERGLLCSALQQQQRQRSRADQAVHPVPVFESASVMVAEVSRVRFHQLPCNVHTKFHINIGHSTVMGTMRFFSRPTVCLPSDSQAGEELAEEPPFDLMQESQYVEELGEEAFITFECPSEDKHRWPGRPIAVKRGPLTYFAIVLLEKPILAAIGTPLIAARLDVERENMCRIALAGRVRALLHDDKDDAVMWRSMPIVRYKSRSLVVERVVSDRSCIASGVVTSEMHEARSGGGMSTNKKERDTKVKDALHAEVQKFIGLTVYFRPTSGDDGCCVNENGPGGLREGIIDSAFGKTGKVKLVFKEPVFAVDDRGAEAGKGKRNEVIFLSEGVVELTLKKYPLALHSQLQQ
The following text describes a protein:
Function:
Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Sequence:
MGPGQAGGALLLRLLMLVQGILNCLAYNVGLPGAKIFSGPSSEQFGYSVQQLTNPQGNWLLVGSPWSGFPENRMGDVYKCPVDLPTATCEKLNLQNSASISNVTEIKTNMSLGLTLTRNPGTGGFLTCGPLWAHQCGNQYYATGICSDVSPDFQFLTSFSPAVQACPSLVDVVVVCDESNSIYPWEAVKNFLVKFVTGLDIGPKKTQVALIQYANEPRIIFNLNDFETKEDMVQATSETRQHGGDLTNTFRAIEFARDYAYSQTSGGRPGATKVMVVVTDGESHDGSKLKTVIQQCNDDEILRFGIAVLGYLNRNALDTKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMAQVGFSADYAPQNDILMLGAVGAFDWSGTLVQETSHKPVIFPKQAFDQVLQDRNHSSFLGYSVAAISTEDGVHFVAGAPRANYTGQIVLYSVNKQGNVTVIQSHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPTYMNDLKKEEGKVYLFTITKGILNQHQFLEGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKILGSNGAFRRHLQFFGRSLDGYGDLNGDSITDVSIGALGQVIQLWSQSIADVAIEALFTPDKITLLNKDAKITLKLCFRAEFRPAGQNNQVAILFNMTLDADGHSSRVTSRGVFRENSERFLQKNMVVNEVQKCSEHHISIQKPSDVVNPLDLRVDISLENPGTSPALEAYSETVKVFSIPFYKECGSDGICISDLILDVQQLPAIQTQSFIVSNQNKRLTFSVILKNRGESAYNTVVLAEFSENLFFASFSMPVDGTEVTCEVGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQNQAAINFQAFSESQETNKADNSVSLTIPLLYDAELHLTRSTNINFYEISSDENAPSVIKSVEDIGPKFIFSLKVTAGSAPVSMALVTIHIPQYTKEKNPLLYLTGIQTDQAGDISCTAEINPLKLPHTAPSVSFKNENFRHTKELDCRTTSCSNITCWLKDLHMKAEYFINVTTRVWNRTFAASTFQTVQLTAAAEIDTHNPQLFVIEENAVTIPLMIMKPTEKAEVPTGVIIGSIIAGILLLLAMTAGLWKLGFFKRQYKKMGQNPDEMDETTELNS
The following text describes a protein:
Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein. Cell projection, dendritic spine.
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
The following text describes a protein:
Function:
Dioxygenase that catalyzes the cleavage of the aromatic ring of 5-nitrosalicylate (5NSA) without prior removal of the nitro group in biodegradation of 5-nitroanthranilate.
Sequence:
MKWSNKDGYPWSKIIHAEKFFDKVIQNDTRPGKWEWADVVSGLRDLDKDPRMNSERRYVAIVNEDVGLGETKGIGITPGLFCGCQLIHPGEEVTSHRHNSVALYFIVEGTGELEVEGEVYSYKPFDIMTCPAWSYHAWRATGDKDTLMYVIHDMALLAYMRALFWEEPKGSENIRHMVKGSTHTWSNTKAPEVSKTQAAKELLKQGE
The following text describes a protein:
Function:
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR). Also involved in the vitellogenin receptor mediated endocytosis of nutrients during oogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MDALKSAGRAIIRSPSIAKQSWGGGGKHKKLPENWTDTRETLLEGMLFHLKYLGMTLVEQPKGEELSATAVKRIVATAKASGKKLQKVLLKVSPRGIILHDRATNQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNETLECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSRENKEKRESGSDGEGASSSQSDGSSSITSLKASASANLLDLEDCTKAFDVLNASDNHIEDVLRQNASNENNNIVWELDDGLDEAFARLAESRTNPQVLDIGLTSNDLQSEECLSPTSWDNLELNPAEADEPFMF
The following text describes a protein:
Function:
Golgi-anchored protein which modulates its interactors acitivies by tethering them to the Golgi apparatus. Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus. Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis. Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPVSLKDNPYITDGYRAYLPSRLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASREDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVFYAFYCNNYWRQVYLITVLAMILAVFFAQIHPSYLTQQWQRLRPIIFCSVSGYGVIPTLHWVWLNGGVSAPIVQDFAPRVIVMYVIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHVLAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
Sequence:
MRSEKEQRTGSRERGSVEIQFRDCQDNAAVNPKHKEEKKEIFSKVVIRRLPPSLSKDQLQEHLSPLPSFDYFEFFPADQSLYPHLFSRAYINFKNPEDIIIFRDRFDGYVFIDNKGQEYPAVVEFAPFQKVSKKKLKKKDAKAGTIEEDPEYRRFLENYSCDEEKSMANPETLLGEIEAKTRELIAKRTTPLLEYIKNKKLEKQRIREEKREERRRRELEKKRQREEEKRKRREEERQKRKEAEKQKKLSEKEIKIKLLKKCDRDDDVDSDRLKDKGDSGETEKNRWEKPGGHTKSKDSKDNRSQMENDKEQREGHGRRQRDKDHRGRDEERKRQRHHYEFDKFMRRKEETKWGKGYCQDRAKKDQHHGYSYCPETGDKLGKEDREDMGSRKERIRNKDRPAMQLYQPGARNRKRMGSGNKTFDFPPISPEHAGEHCYKTVIGTGSEKSADE
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MQVSQELIDRVLRLVHAAEYRPSKPKQIAALLELDADGYREVRRVIKQLVLEGRLIYGGNHLVVAAAAVGGPTDQIRGTFRRAMGGGFGFVRPSSGGGNADADVPEDVFVPTGMTAGALEGDLVAVTIEPSRRGGIEGKVVEVLQRARRQFTGTFFSSPQPDQPGSDTIEGPVVYLDGVHYEAPVSVGDVRGLPLQDGDKIFVEIVDFPDEESGGGEAVILERLGSSKNPAIDTLTIMRQYALPDEFSEDVLDEAREQADAFDDDVVPTDRKDLTDMLTITIDPFDARDFDDAISLQREDGRWRLWVHIADVSHFVPPGGKLDVEARRRGTSVYLPDRVIPMIPEIISNHLASLQPERMRLVKTVEIEMLDDLTITHSEVHNAAIRSDKRFNYEQIDQFIASPAAFQKDWGDSICELLTHMHTLAMQIRKRRFKDGALSMDMPDIKLELDRTGKVKGAYQTENTESHQIIEEFMLLGNEAVATWLDDQELNFLHRIHAPPERRKLRQLTSFVKDLGLGFDNVESRFEIQAVLDKVAGTTLENAVNFAVLKSMSKAVYGPHREGHYALDKEHYCHFTSPIRRYPDLSVHRLVQRLIEQKSTPDESFAELVKLGHECSDAERNAAQAERELIQLKLLHFLKKKQGETLEAVISRVFADGIHARCLKLPVDGFIPVTELPSDQYRFERRGQSLTGFKSGNRFRLGDHLTVRIGKVDLQDRQLYLEVVKNHSAAKSDPRGPSGSKSKKSPLRHQKKSDRREKKKRRRR
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Sequence:
MDVQETTAACRDAFAELASPACIHDPYPFMRWLREHDPVHRAASGLFLLSRHADIFWAFKATGDAFRGPAPGELARYFSRAATSPSLNLLASTLAMKDPPTHTRLRRLISRDFTMGQIDNLRPSIARIVAARLDGITPALERGEAVDLHREFALALPMLVFAELFGMPQDDMFELAAGIGTILEGLGPHASDPQLAAADAASARVQAYFGDLIQRKRTDPRRDIVSMLVGAHDDDADTLSDAELISMLWGMLLGGFVTTAASIDHAVLAMLAYPEQRHWLQADAARVRAFVEEVLRCDAPAMFSSIPRIAQRDIELGGVVIPKNADVRVLIASGNRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQLARVQLAESLPRIQARFPTLAFAGQPTREPSAFLRTFRTLPVRLHAQGS
The following text describes a protein:
Function:
Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSFFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFTTSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFVSMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNVYKRSRRHG
The following text describes a protein:
Function:
Does not exhibit any ribonuclease activity.
Subcellular Localization:
Secreted.
Sequence:
MSINPLSHSGNSPCPFPLGHLMRAKSGSSAGLGLSKENMWTLINTQPLLLLFLLLRPLLFLKTDDYAISGAKEEEFYDYMEELYAVGPTKPPTRESFKKRVLVSSDGKPLADKDYCNEEMKMKNVHNRFFCVKEHFFLQASYESIRHICYNLFVPCRNNVRKCHRGREIIKAVHCLLISGITMPTCMYKSTYKEGLVLLTCQWENEIGDIIPNHVNDIILV
The following text describes a protein:
Function:
Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
Sequence:
MDGDLRGDTVHIGGDARQRFHDARGYGYPLGGNDIAVSLVEAAHLLFRGDLDSVDGMGFRAFLTDREAGFAARFLVYVDLRDRGFYLVPDRDPWWRDPGDGDFVVFPRGNTRRDGVVKHRVRVVDERTTLPVDGLSESVLAVVDEESEITYLDIAPETPTGETTLDRPTDVPGVLLDDRVLVWEPPQRLHNAGFYGQPLGGRAADHDALQLSLVEAAYLIDAGVLRLTDATIDDVRARGRLGEGEHFDCRLAVYRALRDAGAVPKTGFKFGADFRVYSAVSSVDDLGHSELLVRVITDTHVFSPGDLSLDVRLAHGVRKRMVFAATDDTDDTIRWLSVSRLTP
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAFPLPRGITPPEISFLAEMELVTIVPRQRLEGLELLGGPVAPLIPPRRTNVPLWLALLLKRQRRANILPPPWLHPESLSLILDIETRDQAYQHAFSPPPPLPGQPSLRERSYKKSTARPRFTPEGTKYYATPPFLPQNVAQDQAFDAFESEPPTLPFHWLEVGTMLLDAAADDLVDPDQTRRLLKELREVRSAKIRSGVEVLDDAAGPGGGVALTGVGAMEIGEGRGFISGVVDGLRRIGASKEQARREQLADATNREYDDMQDYNDEMEF
The following text describes a protein:
Function:
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MLRLLRLLLLLLLPPPGSPEPPEPPGLAQLSPGSPPQAPDLLYADGLRAYSAGAWAPAVALLREALRSRAALGRARQECGASCAAEPGAALPSQLLGAPHPVSGPGVWEPLLLRATLRRAECLTQCAVRRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAASAAHTFFVANPTHLQMREDMAKYRRMSAIRPQSFRDLVTPLYWAAYDTGLELLEQREAALALPQLEEALQGSLAHMESCRAACEGPEEHQGAEEEGEGSQGGLYEAIAGHWIRVLQCRQHCVADTATRPGRSFPVQDFLLSQLRRLHEAYAQVGNMSQAMENVLSVLLFYPEDEAAKKALNQYQTQLGEPRPDLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDSWTPEALIPKALRERLREDQEKKPWDHQPPQQKPLAHWKDALLMEGVTLTQDAQQLNGSERAVLDGLLTSAECGVLLQLAKDAAQAGARSGYRGRRSPHSPHERFEGLTVLKAAQLARAGTVGRPGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFKGGDLFFTQPNALTVTAQVRPRCGRLVAFSSGGENPHGVWAVTRGRRCALALWHTWAPEHSEQEWTEAKELLQEEEEEEEEEDILSRDPSPEPPSHKLQRVQEKAGKPRRVRVREEL