lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN.
Subcellular Localization:
Nucleus.
Sequence:
MEASLGVQMDEPMAFSPLHGRFQADGSLKKHEQNFKLPGVKKDIEKLYEAVPQLGNVFKIKDKIGEGTFSSVYLATAQLQVGPEETIALKHLIPTSHPVRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMFNLFRALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQESCSQNKSYVITGSKISLSGPAAPKELDPQPTTKTSVKRPYTHAQIQIKQGQDGKEGSVGLSVQRSVFGERNFNIHSSVSHESPAVKLMKQSKTVDLLSRKLATKKKAISTKVVNSGVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCEKLRGVNSSTPRLAGDVRELASPDPSFSEKPDRKAADLLLTPSAQAWGPSVCKEGGDSCGAHSDETAATSGGGWDEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
The following text describes a protein:
Function:
Involved in the regulation of glucose metabolism. Represses its own expression as well as that of the gluconate permease GntP. It employs an effector mediated de-repression mechanism: in the absence of ligand, GntR binds to the gntR and gntP promoters and represses their expression. The release of promoter bound GntR is induced by gluconate and 6-phosphogluconate that bind with similar apparent affinities to the GntR/DNA complex. The release of GntR leads to transcription of the genes.
Sequence:
MSITKNDKNTRTTGRPTLNEVARRAGVSPITASRALRGVASVAEELAQKVRDAARELGYVANPAARALASAQSHSVAVLVPSLANLLFIETLEAIHAVLRPQGLEVLIGNFHYSRNEEEDLIRNYLAYQPRGLLLTGFERTESARRMIEASGIPCVYMMDLDSGSGLNCVGFSQLRAGEAAAEHLLARGRRRLAYIGAQLDQRTLLRGEGFRRALQKAGCYDPGLEILTPRPSSVALGGELFVQLLASQPQVDGVFFCNDDLAQGALLEALRRGVKVPEQIAVLGFNDLPGSDCTVPRLSSIRTPREAIGRRAAEQLLALIAGKEVRDSALDMGFELMAREST
The following text describes a protein:
Function:
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
Subcellular Localization:
Cytoplasm.
Sequence:
MPLAHIKTNLSPDQFSDDFMKETSQMIAELLEKEEWRVTVHVDAGQRMLRAGSFEPYIQFEIAAIKSFDDEADKEKYSKAFFDYLSEKLPVKYDRIVVIFHRLASEDVGIKGTLNSILVKK
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.
Subcellular Localization:
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cell projection, dendrite. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAAVALNKGPARQAKCCAH
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSISGTLSNYYVDSIISHDSEEPPAAKFSSGQYSNSRQSSHTEHLEFPSCSFQPKSSVFSASWTPLTPHAAASLPSVYHPYLQHQNLPSSESRYLRSWLDPVPRAESLAGQGAVKTEPLLGEIRKQGAQDYPIDPAAAAAAGREGVAPAPVPVPRPSSSGGFEDNKVCEGSEDKSRPDQTPELKIDKNLAQENRSVPEGQGAGGRPVHASLEGNPAANWLHARSSRKKRCPYTKYQTLELEKEFLFNMYLTRDRRHEVARLLNLSERQVKIWFQNRRMKMKKMNKEQGKE
The following text describes a protein:
Function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Involved in the salvage pathway for NAD(+) biosynthesis via NMN. Involved in the filamentation pathway. Suppresses the filamentation defect of a KSS1 deletion.
Miscellaneous:
MISCELLANEOUS: Present with 830 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKKTFEQFRKSNLLFQVLKGPQHLECQKLFVLDSSFNPPHLAHFQLLSQTIKNFKLKDTRSHVLLLLAVNNADKLPKPASFPTRLEMMCLFADYLQEKLPQSVVSVGLTVFSKFIDKDKILHEQFVKGCSADIGYLVGFDTIARIFDEKYYHPLKISDVMESFMSGSQLYCLARGDCHLSAESQLRYASDILEGKFEPVIPREWGARIHVMQNDYPALRNVSSSEIRNKLKNGQVESLKDELPLCIYDYLINNKTIFD
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MSMGEVGESGNRETQRVSVQMNGLPGDLLQRVIAGNLFPRKFEEAASEETGEIELSLGLSLNGRFGVDPKKAKMLTRSSSISDFMTPLRYQDRASTVLPITALTRTCSLPMETEEEWRKRKELQTLRRLEAKRKRTAKQRSYKTARSRDRDRASLEENCEEDKVVEDKPPMGRNGNHLQQPYLGMPSWTIGGFIPSKTERANGLGDGGLKGNTTPPPPPPPPLPPSSQGSVGSQRSSSGISEFESQPMQVKGVNKCSEARSPASIQSLPGQSEQKPLISPGTPEKSGKVGGVVAENQPKKPTISSRGVSEMARKVMEDMPCVSTTGDGPNGKKVDGFLYRYKKGEEVRIVCVCHGTFLSPAEFVKHAGGSDVAHPLRHIVVYPSSLL
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTWIPLHCHSQYSILDATCSIKKFVAKAVEYQIPALALTDHGNLFGAVEFYKTCKQNAIKPIIGCELYVAPSSRFDKKKERKSRVANHLILLCKDEEGYRNLCLLSSLAYTEGFYYVPRIDRDLLSQHSKGLICLSACLSGSVAQAALESEEDLEKDLLWYQDLFQEDFFSEVQLHKSSEEKVALFEETWLKQNYYQFIEKQLKVNEAVLATSKRLGIPSVATNDIHYLNPDDWLAHEILLNVQSREPIRTAKQNTYIPNPKRKTYPSREFYFKSPQEIAELFAAHPETITNTCIVAERCHLELDFETKHYPIYVPEALQKKGSYTEEERYKASSAFLEELCEQGLTSKYTPELLGHIAKKFPGEDPLTLVKERLKLESSIIISKGMCDYLLIVWDIINWAKDHGIPVGPGRGSGAGSVMLFLLGITEIEPIRFDLFFERFINPERISYPDIDIDICMIGRERVINYAIERHGKDNVAQIITFGTMKAKMAIKDVGRTLDTPLAKVNFIAKHIPDLNATITSALEADPELRQLYVDDAEAAEVIDMAKKLEGSIRNTGVHAAGVIICGDPLTNHIPICVPKDSSMISTQYSMKPVESVGMLKVDFLGLKTLTGIHIATQAIYKKTGILLRAATIPLDDQNTFSLLHQGKTMGIFQMESRGMQDLAKNLRPDAFEEIIAIGALYRPGPMDMIPSFINRKHGKENIEYDHPLMEPILKETFGIMVYQEQVMQIAGSLAKYSLGEGDVLRRAMGKKDHEQMVKEREKFCSRAAANGIDPSIATTIFDKMEKFASYGFNKSHAAAYGLITYTTAYLKANYPKEWLAALLTCDYDDIEKVGKLIQEAHSMNILVLPPDINESGQDFEATQKGIRFSLGAVKGVGMSIVDSIVEEREKNGPYKSLQDFVQRADFKKVTKKQLENLVDAGTFDCFEPNKDLALAILNDLYDTFSREKKEAATGVLTFFSLDSMARDPVKITVSPENVIQRSPKELLKREKELLGVYLTAHPMDAVEHMLPFLSVVPARDFEGLPHGTIIRTVFLIDKVTTKISSAEQKKFALLQVSDEVDSYELPIWADMYAEYRDLLEEDRLIYAILAIDRRSDSLRLSCRWMRDLSTVNDSVIAECDEVYDRLKSQKVYSSTKKSTGAQSSAMIKKVETREISPVTISLDLNKLRHSHLFILKGLIRKYSGSQALSLVFTKDNQRFASISPDADFFVTDDISSLLQEIEATNIPARVLATTV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSAQRSLVRRITGVRLQVRMLHHTTKTSTATSQIDTTSAGDFKHSEVLSKVMSPLMSINHVKEAPSLKNYHNNKITYRSYLNLNPEKYDLDEEEKIVKYYSSKNDGVEVQPYAPEIQYLKNILESFSEQKYFDKIDQVLKSLSKLVNATEFTDICNKYLENILQDDSLSLQDLNSIIGQLQDKCKFKTNTRTEAIILGKMLNDSDNAQSSISEFFGNMEKQTIVEILRNMDVIGVDNLYKVFDCDSIDASVIPKELQEIYQEHKSKDHDDEIAEDILKLQENKQINPLDKKSLEELLPVDSFGLQVIRHSLLGLKPDSEAALKFADQVEKIIEDVDDEVLNQDIMSGKINYFEMYSKLKTEEQRQAFNEALNVFNLERQKQIEIRGIEGAKEKWKHDFEESQKRGDLNLSKGLNAQCYKWLQDVLPVLEKEYKLCEALINGNNSVIEKDDPNAKDRAMYAPFILKISPDKAIIITILELFKLHSTGGVVRGFRAYKAIQSVGKAIEAEYRIGLQAKKENKLFSQKHLSPQLQKLMRRTMQKGNESTPEWDDATRARIGGVLVSILMSVAKVNVRKETPQGLIEDFHPAFYHGMQFIAGNRVGVIKVHTDISNILSGTSLTESIQPQALPMLVEPKPWNSFYGGGSLYSKTPLVRVKDSPETEAYLKAANERGNLTGVFEGLNVLGNTAWTVNKKVFNVISHYWNSGEEFLSIPPVSEEPQLPQDIPGNSDPQKLLHHTTSKYQALDEYISNKSQRCDNNYRLEIARAFIGEKLFFPHNLDFRGRAYPISPHFNHLGGDLTRSLFLFWDGKELGEEGLNWLKIQLANVYGVDKESLAKRVEFVNENLEKVLESAADPFATDAWWQKAEKPWQALSVCFELAEAYKLDDPTKFVSHLPVHQDGTCNGLQHYAALGGDVEGANQVNLNPSDKPQDVYTYVAKLVETRVKADAEKGDELAIFLQDKIKRKVVKQTVMTNVYGVTFIGAIEQIRKQIIHLFPKDADHHAAARYLAVQVFASIRELFENAHFIQAWLTESAKRITKSVTLDFGESQYSEQELLSTVIWTTPLGLPCVQPYRLHKKKQLKTAVQDLNIVMPSNTSAVDSRKQQNGFPPNFIHSLDATHMLMTATKCAEFDLNFASVHDSFWTHAADVPQMNRIIREQFVKLHTTNLIELLKEEFSERYKDNYQVLPIPNNHELARKVKAIKKEWAEALNRPVQIADELYMERKRLQMLESEDPEEVEVAKNMETTISITMNYKPYEFANRQVSNSFQILVPIQFPEVPSKGEFDVNLVKQSQYFFS
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
Subcellular Localization:
Cytoplasm.
Sequence:
MQHPAEHSPLGKTSEYVSSYTPSLLFPISRTAKWAELGLSAETLPYRGVDIWNCYELSWLTPAGKPVVAIGEFSIPADSPNIIESKSFKLYLNSLNQSAFDSREALRAVLQKDLSAAVGAPVGVRLRSLDEVAEEGIGRLPGRCIDELDIAVDGYEQPRPELLRCDAGRIVEEQLYSHLLKSNCPVTGQPDWGTLVVDYRGPALDPASLLAYLVSFRQHQDFHEQCVERIFLDLQRLLQPQALSVYARYVRRGGLDINPYRSLAEVAPDNRRLVRQ
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm.
Sequence:
MENDIPSEAEMGALFEAAMRQQQKATKAGAAPKVTQEEQHKFLSAMKDAEFRSLLNEYMQEISDPRNRAETEQYLAQLENEQKVPTDKQLVKPTPGFVIKTKWEASQKIFVNVCSSEKMQPPSSTKVTTGQQGSSWNLPYSLGPERLEPDKGGSSVPTFDVCFHPRVIEFAMSRGDYRHMAISTCLDAVEPILRETRRKPKALLARNYHILKGVFYKSGDPVTMCLKKERDAPEPAKSATKVMQSKTKSTSRESGDKIAVLGDEKNALPLQTIERVETKPGDSVLSELTHVEQNEKSSPLIKEVSSTKLDAKQQIGKRKKEMEHQLIYRGRFELLHHMQADPGKNVPEDRHRPKELVVEISFPLSSSAKGLDLDVSERMVRLSAGPDVPGNYEPLELALPFPVIEDKGTAKFDRKNHKLVVTLPVQPPPTPKPQSVSLIFQDEDEDGEQEEVKRESESHGGQTETTVRASTKTLAPKQKKEGEDEFRMFRETALMVANDPQVLAYAQRKARSEKSALSTRPSPSVITEPAATKDDIFDDLPPLESCSDEEEEIDTTANAEEAVKASPPILTAAANPVSEIKDVAEPIQPPFETHATDACLSYIVGVAGIASASVKLTFPTTSSLKLRFSDSDGRVYEMQVAVLPIDVEPSSAEFDVASENMVVILQKKFAPDSASQPGPPKEAAEFEAPAPPLTAARFQNQLLYELD
The following text describes a protein:
Function:
Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).
Sequence:
MIPVLFGHLNSSDAIERQPAEAQSRDTLHRRNPTLATQVLQARAASSPSRRKKGRKGRDSGDVSRAPRAMRPLGFAASWEQAVMAPGVSALGSLVAVLYDAQAFKFGNFVLKSGLSSPVYIDLRGIVSRPRLLSQIAEILFQSAQDAGIRFDSVCGVPYTALPLATVICSTHEIPMLIRRKETKNYGTKKLVEGAVNPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDMLRAHGIRLHSVCTVSKVLEILEQQKKINPEMVERVKRFIQENVFVAANPNGSLPSLNGSLPSVKKAPKELSFGARAELPSTHPLASKLLRLMQKKETNLCLSADISESRELLQLADVLGPSICMLKTHVDILNDFTLDVMKELTTLAERHDFLIFEDRKFADIGNTVKKQYEGGVFKIASWADLVNAHVVPGSGVVKGLREVGLPLHRGCLLVAEMSSAGSLATGNYTEAVVRMAEEHPEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYSSPQEVIGKRGSDIIIVGRGITTSANRLEAAEMYRKAAWEAYLSRLGV
The following text describes a protein:
Function:
May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity).
Subcellular Localization:
Apical cell membrane. Cell junction, tight junction. Cytoplasm, cytoskeleton. Note=Associates with cortical F-actin.
Domain:
The ASD1 domain mediates F-actin binding.
Sequence:
MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK
The following text describes a protein:
Function:
Transforms N(2)-succinylglutamate into succinate and glutamate.
Sequence:
MLQALLDSKDFLALTLANPQTLGDEFSFTLGEHTRVNVWDTGVIVFEPAQPQGKDVILSCGVHGNETAPIELCNTLIKQLLQQKIIAKQRTLFLIGNPLAINNGTRIIDENMNRLFSGEHSNPPGLVNPERLRAKKLETYVDRFFKAAAAGRQRIHYDLHTAMRASKHEKFAIYPYRPGRAYSAEQIMFLAASGVDTVLFHHEPTTTFSYFSSEQYGADAFTIELGKVYPMGQNDMTRFIAAQEMFTRLITDKPLQLESFSTDKVNLYQVCRVINKHFDDFEFTFATDVENFRAFPKGFVLAREGGQEIKVEQEVESIVFPNAKVPIGNRTVICLIPSVAPDVR
The following text describes a protein:
Function:
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKITLGNTLPPYPAFIEGIRRAPDRSYMLTPAQTATALKNALRYIPLELHEQLAPEFMEELRTRGRIYGYRFRPAGDLKARPIDEYRGKCVEGKAFQVMIDNNLCFDIALYPYELVTYGETGQVCQNWMQYLLIKQYLEELTPEQTLVIESGHPLGLFRSRPDAPRVIITNSMMIGQFDNQHDWHIAAQMGVANYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLGIPQDKDLRGHLFVSSGLGGMSGAQPKAAEIAGAASIIAEVDSSRIETRYRQGWVGHVTQDLSEAFRLAKEAMERREPCSIAYHGNVVDLLEYAEREQIHIELLSDQTSCHAVYEGGYCPVGLTFEERTRLLHESPDQFRRLADASLRRHFEVIRKLVACGTYFFDYGNSFMKAIYDAGVKEISRNGVDEKDGFIWPSYVEDIMGPQLFDYGYGPFRWVCLSGRHEDLIKTDRAAMECIDVNRRGQDLDNYNWIRDAEKNRLVVGTQARILYQDAVGRMNIALRFNEMVRRGEVGPIMLGRDHHDVSGTDSPFRETSNIKDGSNVMADMAVQCFAGNCARGMSLVALHNGGGVGIGKAINGGFGMVCDGSERVDEILRSAMLWDVMGGVARRSWARNPHAMETSDAFNESHSEGYHITMPYLADDELIKKTIKEAL
The following text describes a protein:
Function:
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
Miscellaneous:
MISCELLANEOUS: When the channel is activated, one or more imidazole moieties of His-37 probably become bi-protonated.
Subcellular Localization:
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Domain:
Cytoplasmic tail plays an important role in virion assembly and morphogenesis.
Sequence:
MSLLTEVETPIRNEWGCRCNGSSDPLAIAANIIGILHLILWILDRLFFKCIYRRFKYGLKGGPSTEGVPKSMREEYRKEQQSAVDADDGHFVSIELE
The following text describes a protein:
Function:
Positively regulates a late step in synaptic vesicle exocytosis.
Sequence:
VMDFIVKQALGGATKDLNKMMDKGGEEADPKAEEAQKEQLEAMAEQEAERKAKHTKMEAEREKERQRIRDKYGLKRKDEIEAEEKANRERETVGRLGRKQTFEEEQEEEEEESVLSQAEKTFSELQQKVTNAADGCTIS
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKNKISTAEMMEKESISKVLLKLSVPAIIAMLINAIYNIVDTMFVGMLNNTSAIAAVSIVYPLFMFIGAIGVMFGAGGASYLSRLLGEKKKEEADRTLTSTIVIGCIFSLIFTVICIIFLEQFLLMYGATETTMPYAKEYGYTIVAGSIFTIGTAIMSNTIRAEGNSKYSMIATCIGGVINIILDPIFMFKFGMGIKGAAVATVISQLVSFIFLLRYYYSKKSYIKLGIKFFKPTFNMFFEILKIGIPIFVTQVLASFALGFMNLGAKPYGDAAVAAMGIVFRVMSIGFYIVFGIGQGFQPVAGYNYGAKNFTRLKEAVKLSIKWSVVSGIVISILFIVFAEGCMLIFTRDREVINIGIKAFRAASLLFPLFGYVNTYAVLYQALGKALGAFILSISRQGIFYIPLMYILPKFMGLAGVIFCQTAADGLAFIETFIMAIWLNKSLKKEMVQDTNLDSVKKVSSF
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
MMLIWCFMRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNIDDL
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming.
Miscellaneous:
MISCELLANEOUS: The signaling mechanism of chemotaxis in B.subtilis appears to be inverted in comparison to E.coli.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYKEHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFIVKPFQADRVLEAINKTLN
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MKKERLEQASAFGKDRVKKKKNTDTSSNLIPVPKGATKEKKRVGRGPGSKVGKTAGRGSKGQYARNTVRRGFEGGQMPIHRRLPKRGFTSKFHKEFYPVNLRDIEKSGLTGNIDAKIMVQSKILDKETTLFKILGTGEIKKAIHVIADGFSQSAKEKIEKAGGSIKLRAELKLATSETKK
The following text describes a protein:
Function:
May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MMLGVYTLLLLWGLATPCLGLLETVGTLARIDKDELGKAIQNSLVGGPILQNVLGTVTSVNQGLLGAGGLLGGGGLLSYGGIFSLVEELSGLKIEELTLPKVSLKLLPGVGVQLNLHTKVSLHGSGPLVGLLQLAAEVNVSSKVALGMSPRGTPILVLKRCSTLLGHISLMSGLLPTPIFGLVEQTLCKVLPGLLCPVVDSVLSVVNELLGATLSLVPLGPLGSVEFTLATLPLISNQYIELDINPIVKSIAGDVIDFPKPRIPVKVPPKEDHTSQVTVPLYLFSTVFGLLQTNGALDLDITPEMVPRNVPLTTTDLAALAPEALGKLPPAQHLLLSLRVTKSPMVLLQNKKATVSIPVTIHVLSSVPQGTPVALFQLNGVMTLNAHLAPSSTKLHISLSLERLSVQLASSFPQPFDASRLEEWLSDVVRAAYMQRLNEHLEVGIPLPKILNVNFANSVVDIIENAVVLTVAP
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular Localization:
Nucleus.
Sequence:
MQDLTSAAAYYHQSMMMTTAKQNQPELPEQEQLKCPRCDSPNTKFCYYNNYNLSQPRHFCKNCRRYWTKGGALRNIPVGGGTRKSNKRSGSSPSSNLKNQTVAEKPDHHGSGSEEKEERVSGQEMNPTRMLYGLPVGDPNGASFSSLLASNMQMGGLVYESGSRWLPGMDLGLGSVRRSDDTWTDLAMNRMEKN
The following text describes a protein:
Function:
Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives.
Subcellular Localization:
Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein.
Sequence:
MGFEGEKREEEEGVRMANDFFWSYTDEPHASRRRQILSQYPQIKHLFGPDPFAFLKISGVVLLQLWTATFLHDATWLKILIVAYFFGSFLNHNLFLAIHELSHNLAFSTPTYNRWLGIFANLPIGVPMSVTFQKYHLEHHRFQGVDGIDMDIPSQTEAHVVKNVLAKSIWVILQLFFYAFRPLFLKPKPPGVWEFINFTIQLSLDGAVVYFWGWKSLAYLILSTFVGGGMHPMAGHFISEHYVFKPEQETYSYYGPLNLMTWSVGYHNEHHDFPRIPGSKLYKVKEIAPEYYENLDAYKSWSQVIYMYIMDRTVGPFSRMKRKLSTKANKSE
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MQHRRCTIVFLLLLSLPLFTKQFAGEPIECFTPTYFTEAQSRYVNSYCWTVSTFYMDQNQPQPSQQPQPPTSNGDSLEAKRTIYENDYGNGRVKVSYYQWAPMILLAKAITFYVPFAIWKSLARRRGISLRQLMKRITRLSQISPSHPDRSNLLHEILEQIQFLVRGSNRSKQQSGTVNNKPQRTVSPIKLTMQQSQLFITFLFIKILYLLNDLLQFYLLVTFLGDDYLTHGWEIIRHLWTKRQWWSSPRFPLQTLCSVRAAQQGSLRLYQCHCVLPINLFNEKICSIWWFYIVALLPLTITSLLIWCYRNCLASVRVEFVEHYLYPNIDMSSDEEDDSLRLNCRSFTIDYLGCDGVFVLRLIEINHGSTTLRTIVQELYKRSGYLQNVTNNPESRPSTPIPTIAVAIPQVTNQNIYSFMDNYSLLTSIDTELFA
The following text describes a protein:
Function:
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MCGSTQSFPAATQHSSDILTAEESQETGEFTMKMDVEDADMTKWTELEFEEKCTYIVKDHPWESSTDSGSLTRAEASLPRNLLFKHAPNSKEVIGVTSKEYIPKGTRFGPLVGESYTTETVPKNANRKYFWRIYCNGEFHHFVDGFNEEKSNWMRYVNPAHSQQEQNLAACQNGMNIYFYTVKPIPANQELLVWYCPEFAERLHYPPSGDLMMLKLKQSLMEAKQNATETDSIQEKSSGKKEHSVSEILKGTRRDPVRPQSSPTKSLQDSPKKPSLEQPFFPRVVYPVRPHINEEYLKANTVYGLDRPSYVTHSPVQSSATPSPSARSSPEHSLQSSSPHSSPGLTLSPPTPSSQEHKEGFPFPNGLYSRGGLGHYPGYTPPSHLGPAFLHSYSSVSPHYSRYLLPHYPVGCNSITSLNGLGAGPVGSLFPRMYPLYSNLLSGGSLSQHMLSQSPLPSMLPSEGGRRLLFPSEPHRDLLIPAPNSAFSATGLASSLKDKPSSPSNGSPTAGTAASSSEHGMPTKPTSAMLASSRSEEEAINLTKIKRNITGYKTLPYPLKKQNGKIKYECNVCSKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKLCPAKFTQFVHLKLHKRLHTRDRPHKCLHCHHSYIHLCSLKVHLKGNCLASPNPRGRSPEELNHINEEIEKFDISDNADRLEEMDNVDVESAVEKQILNMLWREMDLKASYHKSMGNGLRSTGYGLYEPNNETSVIKLPHSSPLPLLSIKVKQESLEPIDP
The following text describes a protein:
Function:
Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum and/or Golgi.
Sequence:
MKVRSAGGDGDALCVTEEDLAGDDEDMPTFPCTQKGRPGPRCSRCQKNLSLHTSVRILYLFLALLLVAVAVLASLVFRKVDSLSEDISLTQSIYDKKLVLMQKNLQGLDPKALNNCSFCHEAGQLGPEIRKLQEELEGIQKLLLAQEVQLDQTLQAQEVLSTTSRQISQEMGSCSFSIHQVNQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKAAVHQINFTVGQTSEWIHGIQRKTDEETLTLQKIVTDWQNYTRLFSGLRTTSTKTGEAVKNIQATLGASSQRISQNSESMHDLVLQVMGLQLQLDNISSFLDDHEENMHDLQYHTHYAQNRTVERFESLEGRMASHEIEIGTIFTNINATDNHVHSMLKYLDDVRLSCTLGFHTHAEELYYLNKSVSIMLGTTDLLRERFSLLSARLDLNVRNLSMIVEEMKAVDTQHGEILRNVTILRGAPGPPGPRGFKGDMGVKGPVGGRGPKGDPGSLGPLGPQGPQGQPGEAGPVGERGPVGPRGFPGLKGSKGSFGTGGPRGQPGPKGDIGPPGPEGPPGSPGPSGPQGKPGIAGKTGSPGQRGAMGPKGEPGIQGPPGLPGPPGPPGSQSFY
The following text describes a protein:
Function:
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MDYSNFGNSASKKFQDDTLNRVRKEHEEALKKLREENFSSNTSELGNKKHYRAQERMSSPLHRLSPTGKSDDRKVKSPLDDKLRRQLREGNTRLPPPPFSSYGMPPTNRSNLDRIRRRTSSPVRTDKFASQNVIDDQRLEIKYLERIVYDQGTVIDNLTSRITRLESFILNSISDRGDKNFASLEHSRSFSGFPTNKTYGLQMGGLYENDMPYRRSSDNINKEGAREDRSSQIHIENESTEDILKILSSSFHN