lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MRKKRRVPVVLWRLFGDRALTLSATITSFIPQSHPTSFLLQQPRDPSDYIKLLNHSYVVLDSNAPPFAAAKFPPSNHWPQHEIVVRTIEMMVREQSTCNHSSPIVELLTSSAWSLLLERIGDDTMVYLLKHTSIFLPLPPKKHCQVAGPPVNSLALKLMKNKAEPRHQDPLVNHFGHKKKRDRVDDANSLSDVQQFNPLCVMGCVGCVSCSGSFIKPSGSHLCNNKGQIDVLQAAAPMYEVHLNEELVNMRKRSRPFKWERCKKRKHSDISESSSTPISRHPVNRCCQMSILEAASPTTGACTVNYEGFPIEKLPGLNQVMAKAKHKKHSRLFRWQRNKKRRHSDVEEASATTSYLMNCIEEDTAPERLQSDLNNIKIHSPDKMPQQCPCCLVLQDALLVTKGAQINRQPIFYSSERSSSVLPRKHLLNSLKPNFSGSKTLFGSIFGLSNVNARAPSVLCSHSSSFCLLGSACLYHSLIKFLKTLIRRNRCCKHLHLLDKHCAVPSLTQAMNQNASSLFEKRRILLAIFSQENDSESVVTKKSRTVSIEHCNRTLTSENLQTGAIRSYCSKSQVVSFIWAVCRSLVPPDLLEKWIFWFFSFLVVPLLQANFYVTESEHGKQDVFYYRKPIWEKLKNTTITGLKDQNYQHLDPSEVKSIIGNRLFGFSKLRLRPKENGARMLVNLKAPSRMLVQESSSTGIPGKAQFVSKSVKYKHFKPVNYVLRDTYAVLKGILVKEPEKLGSSVFDYNDIYRKLGLFIIDLKNGLSTIPNVYIVVSDVSKAFDSVNQDQLLSVMKDILHENEYLLQQSSQVVCTKKSLWVHENLTLMDSEIGAGFTKKSSSGRFGSLHSVLINQGLGRYMKKKEILFNLYEHVKCNVLQLDKTFYLQGIGIPQGSVLSSLLCSVYYGHLERNVLFPFIEITRGPTVEDLSRRCNSWDSSAAGNSSEDRLGSSPYILLRLIDDLCFISTSKKQAESFYTRLLRGFRDYNCYMNEEKFCLSFHSGHELALPSNRVYIGEDGISFLRWSGLLLNSCTLEVQADYTRYLNNHLRSTLTVSWQGKPGRHLKAKLSAFMRPKCHPIFFDSNINTGPVVRLNIYQAFLLCAMKFHCYVSEMYICKLRPGFHLKIIERSFRYMYALIKKMMYSARTGSHFHPILQLEAREVEWLGLNAFVKVLKRKQSRHKELLHLLKLKLLAHEINGNVSSQLEYAVDSSHSSVMWKIKY
The following text describes a protein:
Function:
Required for normal septation. Involved in the disassembly of the medial ring during septation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associates with the medial ring during septation.
Sequence:
MSQQLSFNASSAKPDKSFSNYFWGANDEGYHALLSRFSDVKHINEELRSFYHERANIEEDYAKRMAKLSRTTFSSLETGCLKESVQVMKAEVDNMAKSHLQISQLLQDDVENAFTRYAASLKDKKKMIVSGIEKVHKDKLSKHQALVKAQDKYHYLCKKVNYYVSQQNMLFGKELEKNNAKLNKTQNAITASSSDYQSAVAAVRDSYARWTNEWRSTCDKLQDIEEERRHFLKSVMWTFTLLISRSCFNDDQACERIRKNLEQCSVSQDVLEFIDAKSTGTGIPQPPKFYDYYKGEVPDDSVELVQANFQRAQTKIENDNMPLNRPYVLSATARNESSFENTLPNTPSAIQSLTTVSSNSSQNGRSSPKKSFLSKFKLTSRPSTPNVGNTAPDALSSPRNDSPLTSAADEQMKHLSLQEEPKQNPTPAAPGAFPNSNTLPPRYNELGSLPSPNSVSFTEDSRPNVNTPSRRQQIQEEFGSVLQMENRAVSPVYDSRKNGSRSSFTLRKSRSPKRPSSSLSQNASRLPRSLTPGNLEPNYDFGVRVDPASGTAPTDDEPYTDRDSSFVDDTINTKATGNTSNRLSLPAYPTDGGDTSIDNPTSTDGQRILGYVSALYDYDAAIPEEISFRKGDTIAVLKLYEDGWWEGFVVGEDDHNRGQFPSNFVREIEV
The following text describes a protein:
Function:
Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKCTLLTLQNYVDGKFVPCNSYIDSLNPATGEVYCRVPDSSKQEVDAAVLAAKAAFPAWSSKSPQERSAILYKLADLIESCLEEFAVAESKDQGKTIAFARTVDIPRSAYNFRFFASAILHHTAECTQMDGLACMHYTVRTPVGVAGLISPWNLPLYLLTWKIAPAIAFGNTVVAKPSEMTSVTAWMMCRLLKEAGVPPGVVNIVFGTGPRAGEALVCHPDVPIISFTGSTMTAQRIIEKSAPYCKKLSLELGGKNPAIIFEDANLEECIKTTVRSSFSNQGEICLCTSRIYVQKAIYEVFLKRFVEAAKKWKVGTPSDPTASMGALISANHLEKVRSYVKKALEEGATVLCGEGVNALDIPSENKGGYFMLPTVITELKESSCCMQEEIFGPVTCIVPFDSEEEVIEKANGVKYGLAATVWTRDVGRVHRVAKKLHSGLVWTNCWLIRDLNLPFGGMKASGLGREGAKDSYEFFTEVKTITIKH
The following text describes a protein:
Function:
RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2. May be involved in cellular senescence.
Subcellular Localization:
Cell projection, dendrite. Perikaryon.
Sequence:
MGTFETAVAVYYEEEDEEEEYYEFEPLPTVLEDEENVSLADILSLRDNCLTEQEIWAVCLECALSLRCIAHSALFHTLCITPDTLAFNAHGNVCFMEQLSDDPEGAFVPPEFDRTGNTFEAHVYSLGSTLAAAIEYVIEPELEPQLSHNLKTLLNEMQQERPEDRPNIEAIIRLGELHLMQVSSANICRKLSAIGRRVLSIESVGNFQDGSENSWNIIERKTIVEHKQQVFERNPADGSSSTEDLTSDMNVLSIRIADMTEGNKCAQDIKEVHEALLKGEAIAKDLAQDRAEKEGYTLLNRDECTFELQLESTATAPSSRNNSTYSDIPKIVNAIDAMHIKTVQSFEHLPPRNKNVCSSPSHHFQAPIESNENISSLQNTEFKVSSSNLNNNPAILKSSSLNETAANNNNPMKKSMFCLNEETRDEVSTEYNVNFSKRVKSGVSKPPVCVLVQWISLKELLSRCGRPLTINELFALCHTCLSTLQTYIDYPAAYICMDSVYVGCEGEVLFLIPKKTGSCDTFYIAPEFQQHGIVTEKVCVYGIAAVLWAAAKFNISPNQKLPLPKTLKRLLLEMAKRTPIERPSIAKAQKSCSDYLLQHGTNAEKVWADLINSVHQLFNRHDVMESQNVVDNKILSYQQDPSGFKTGFVPIAGENKLSAVQGPVPCQYSVSNSHLPAAFTSLKTHFRPIVLSQNTDIKAKNQEIQQENGEVLLKDIENEEEEDVNEPLCHEGVQKSPIPDNDFSSTPSSGKTLINSPSSISSDSTNQEKRSNTNSESFSDYAAASALPENSVGNNFNNFLLRQDPKTGLLTLLPVQIAVKEPIPGLEFNIAPLSSSCQKLPSGSRGSKPDEKLEMPVSNKSTVDNASDAEMSCSTYDIEKQVDRHNVVEVVDRMALAPLVSPAKSRGLQKVVHLIKEEFAFDGYLENGVEDLAMEGEYILSLKDLQHGTFCSAISEKFCDLYWDKQLLDELYKVVNRKHGQIILSSSKALSSLDNTAQLASKVKKRAVSPLGRKQRKARDACQCSPPDLHGNRCQKLKVMPTNSQPLPVTGNACLHKKNTEEGKDSGDNVSPDIEDTDSLTSERMPENTCSPSPCPGHIRQCRPGWSVAFYGEDCFREDVQKYVKKLGRQKANSFIYDLQELQQQLMIETRNLKKTRVFYQKLLQQERKNKGSEAKIMLPKVKAQLEEMTSKVEFLQSVKKYLEVLYMEQWGLDLSFLPSLATSGPEFLDLKPSEDNSMLSFQSVTIRGKSNQDKRKTLQSGTPLGLISYLFARNAAVEGYIQQFLYTFRYFCTPEDFLQFLIDKLNSVAGNSANQSTSADCRKVYSRSLDVLQAWVEDCKQVDFSPKSNLLNILEDFIVSKVVPLDSRGESLLVLAKSNPEKRRSYPVPGCCVSSMSMHDDDETKSVHSLCKKISTEDPARKSFQWRISKGAEPQVALRKEKPFSVAAALPRPCYTSLIDEMSSSHLKTEEKYPFFQSEYSVQQTAQQLTLLQQEMFQGCHPVHFLNSRALGVKDKTLNIAKAVSPDNVSAEGSNLFASEMTQDPYILQLLKYADHVSNWVSAETVICDTVKTQTGLLSKFLLIAKLCYESRNFATAMQILGGLENVIVRQLPAWKNLSAKVCEIMEELKAVQVFLKSDNLCLMEGEQFKKLPTIPAAHILTMHVQQLEIGALTMANGAFKWSKLRNIAKIVSQVHAFQENAYNFIPDLELQAYLKQRIAHFSGTDIPLLAAENNTNFHQIPADKHSRKIQDTFRRMKATFQ
The following text describes a protein:
Function:
Poly[ADP-ribose] polymerases modify various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death.
Subcellular Localization:
Nucleus. Chromosome. Note=Associated with condensing chromosomes.
Sequence:
MARRVNKKKSPVKAARKIDGQIGRRVVDGVRAKSSRQRHQAVLYQAPTPTVIRRKTTKTAIVKKTVVVVKKGGKVVKKSSKTGQKVKAVKAPKVKAPSKKGNDRLTPRVITEYQENPFFYDPQVPEYISASVYHRWITRAVRNGNMKEIKDYYKSKKCQKSAIYTSFAYSFDTSACDEALRQDIKFATEFFKMNNKMEVDNSYHPGKEPNLLQKKTTGRKNYYMLGRHTRQIEMGRGGKEGNNALLNYDTRTDEPNPLTKLIEDNVTYTKLYQLCKIPDGPIVEHHIEMHFVTAVRMGHRDLASALAQGPVKMHCNDLHRATLKDQKLPAKILPVSVAKKAYMNKNITPLHTAAISNSTHMLEAMRAVYPTINIPDQDNWYTMHYAACAPGTAPMEFLLKNGGSVTMLTKQTETPLHVAARAGRAVNCTFLMKEMLDLEKGDDGESTIRADRSIINARTRSGNSALHLAVLRNNLDVVDALLAEPTIVVDNPTSTGQNRLTPLMMACGKGYLEMAKKLVEKGALVEGKDKKKRTPLIHAMLNGQIHTAAFLLAKGASLTLADSSGNTAAHYAAAYGFLDCLKLLASIDDNILSEPNDWQLYPLSVAYLKGHYGIVTWLLEGPHKDKANINAKDNNGATLLSNLLSYADETMHKELLSQIEYLVARKADASLADSSGQTPLHLFSMQRIILKGSGEAAENDAMRMTLDNYKKCFNTLIKAGAKVDVYDHEDNTPLHYALTNGNLMLFNLMLDKVANKRNLFEKWANHQNFLHEILALPMKVYGDQVLWKGETLTKPAYDVLPILKELHENLPDLFEKWISEVNKAGYSPIVEAIKQYQALAANKKLRGEADQNGNPGFGNAIARGRVHNQFGRDRMNQSQAPHCDSYELKTFISTVNELFEWVIRLGPFQLTQKYINSENSAAVTLANLAMSIPIECGRHQQNQLALFKILIKLSKEFNKVDEFLTQKNEKDDVLIVQAIMFDKPNVVELILDTASEMHLIHGTHNAIKENELEVVVHKTIIMYMIEMRMWELIPKVNASSEFWKSKDAKGNSVWHYAARVNSHKTVGLFKMIESKGVRRETNDDGRSVLHVATLACDGSADSVLEPIAWLSTRCPIDAVDKFNRTALHYAFGNENDFKEGNVPFGESDPIAVVSLLSSLIRPEQIEIADVNGNTILHLAAIKNSTICLMTLIRKKCHVDLKNKDGNTPLALAVHHGRQSSALTLIQANADVTEKIFVPALKPTSDFDQNSSGTEAEKFWKWHGKEKKVLEDLHTTIPASVVSKGGSWEAMVYVLLDVLGQNTGSMAQLTDAALRRGQLNLANQLLKSIEALIDGAVLNSSYDLLDTFAEKCFGALTSEETIEKTVLNRIILTRGLGLKQPETMKIIRTALQNGNWNLLNFLKSEMGTAWKNQKIETPTENPIRSLLIYMNEKSVSSEAIGFLEELRQMRGVNIDALCQLEIPGKFKKILDYGLIPPISFAVLQENPNMIRALRNAGASLKTQDDYGRTPLMYAIMTNNRSVVDAIVGDGKLAVVLHKQKAVATGPRCVAVPMRFGATSRAFIPAAAFASVPARVESDEEEEDNSGSESGEDGAASENKSEHGSENGESGNGSDDEDDDDDDSSPPPAKKSRIAKEAAGPSTGPKRKKLVITDPSLFSARDHKENNPLHYFIEPLAWENVELLGDLAAANKTAIVQCLIDKRSPNPIELAAMKMNRRMKSEMLKIVKNAAFPRPIKETKLTLQQVHIEPLSDVDEDAAKFLAKWVEEKDKKKTSEAPKPHKSSTYSTNGLVSFCDETQQYFDVLMNKTDLMYGRCGFHNFYRMQIIKRRDAELFILFTNWGRIGSGMGEFQTTPFNSLELAAKEFKSIFKSKSGNEWAPLANFRDMPKKYRLVETDSTPTSLAEIELTWKKNTEKDPIRRMIADISDAKTLKTYASQVQMYGGSSQPFGRFTKENIEKAKLVLDKLEKNANRIKQMVEAQTGVVESNLLDAYITTSELSGDYYSLIPSGEYEFSNLTRLDNVEEIARHRARLNRCQEIETATRLLCAAEFRQDLDRVDYIRSAIQCEYRLETPDSDISQRLLQWIHNSGGKQAKVKMILEISPMLSTEKFEPFVNDDNQKFLWHGTKATNLMSILKNGFLIDPPSACKNGNLFGSGIYLADSFEKSTHYCQPSAGGINYMLVCQTALGKVRTLDTIPYHYMNQSSSSAEKYEDTLHYIGDRFPAGSLTNDGVGMPLLPLRKRDPIQGSNYGFGTLDFSEYIVRNPNRVLPKYIVMYK
The following text describes a protein:
Function:
Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in gammaretroviral surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to loss of infectivity (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells.
Sequence:
MCTPCCVSQLACCCGSAACSLCCGCCPKIKQSTSTRFMYALFFMLVTVTCVIMMSPTVEMAMREHIPFYSQMCQQLNAGENCSTLVGYSAVYKVCFGMACFFFFFAVFTIRVQNSTGCRAAVHNGFWFFKFVALLACCAGGFFLPNQDQFLEVWRYVGAAGGFLFIIIQLMLLVQFAHRWNQNWSSGATYNKLWYAALALVTLVLFSVAVGGMVFMFMYYTHPEACFLNKIFLGVNGGLCFIVSLLAISPCIQTFQPTSGLLQPAVITLYVMYLTFSALASKPIEMVEDEIKGNITVCVFPFKSGLKSDTNIVTGVGTAILFCCILYSCLISTTKRSSAALQVYRNDMPENERARCCFCWVDDTEDYDDEKTSGGQNVKYDERDGTVYSYCFFHFVFFLGSLYVMMTVTNWFHYDNAKIERLLEGSWSVFWIKMASSWVCLFFYMWTLVVPMLFPQRFQA
The following text describes a protein:
Function:
May regulate transcription of undefined genes.
Subcellular Localization:
Nucleus.
Sequence:
MRGERGRGRGRFGSRVGPNTGFRPFVPHIPFDFHVCEMAFPRVKPAPDDSSFSESLLKRNQDLAPSTAEQASILSLVTKINNVIDNLIVAPGNFEVQIEEVRQVGSYKKGTMSTGHNVADLVVILKILPTLEAVSALGIKVVETLRTQDPAEVLTMLTNETGFEISSADATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASHSTVKVLIRLLKDLRSRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVSYKRCLQMLAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGLEGDASALATEMSTWDGVIVTPSEKAYEKPPERKEGEEDENQDIPEGAEEEESMETQE
The following text describes a protein:
Function:
Serves as a specificity factor required for RNase E-mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di-GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Removal of the transmembrane regions (residues 1-156) has no effect on csrB translation, however removal of either the HAMP-like region, EAL or GGDEF domains obviates the activity of CsrD.
Sequence:
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSVLRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLRLVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGERGSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDNQLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGALLARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDTEQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAVTREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENLAIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALGVRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQVYATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
The following text describes a protein:
Function:
RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding membrane-associated proteins with roles in transmembrane transport and vesicular trafficking.
Miscellaneous:
MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Note=Localizes to foci enriched near the periphery of the cell.
Sequence:
MDNKRLYNGNLSNIPEVIDPGITIPIYEEDIRNDTRMNTNARSVRVSDKRGRSSSTSPQKIGSYRTRAGRFSDTLTNLLPSISAKLHHSKKSTPVVVVPPTSSTPDSLNSTTYAPRVSSDSFTVATPLSLQSTTTRTRTRNNTVSSQITASSSLTTDVGNATSANIWSANAESNTSSSPLFDYPLATSYFEPLTRFKSTDNYTLPQTAQLNSFLEKNGNPNIWSSAGNSNTDHLNTPIVNRQRSQSQSTTNRVYTDAPYYQQPAQNYQVQVPPRVPKSTSISPVILDDVDPASINWITANQKVPLVNQISALLPTNTISISNVFPLQPTQQHQQNAVNLTSTSLATLCSQYGKVLSARTLRGLNMALVEFSTVESAICALEALQGKELSKVGAPSTVSFARVLPMYEQPLNVNGFNNTPKQPLLQEQLNHGVLNYQLQQSLQQPELQQQPTSFNQPNLTYCNPTQNLSHLQLSSNENEPYPFPLPPPSLSDSKKDILHTISSFKLEYDHLELNHLLQNALKNKGVSDTNYFGPLPEHNSKVPKRKDTFDAPKLRELRKQFDSNSLSTIEMEQLAIVMLDQLPELSSDYLGNTVIQKLFENSSNIIRDIMLRKCNKYLTSMGVHKNGTWVCQKIIKMANTPRQINLVTSGVSDYCTPLFNDQFGNYVIQGILKFGFPWNSFIFESVLSHFWTIVQNRYGSRAVRACLEADSIITQCQLLTITSLIIVLSPYLATDTNGTLLITWLLDTCTLPNKNLILCDKLVNKNLVKLCCHKLGSLTVLKILNLRGGEEEALSKNKIIHAIFDGPISSDSILFQILDEGNYGPTFIYKVLTSRILDNSVRDEAITKIRQLILNSNINLQSRQLLEEVGLSSAGISPKQSSKNHRKQHPQGFHSPGRARGVSVSSVRSSNSRHNSVIQMNNAGPTPALNFNPAPMSEINSYFNNQQVVYSGNQNQNQNGNSNGLDELNSQFDSFRIANGTNLSLPIVNLPNVSNNNNNYNNSGYSSQMNPLSRSVSHNNNNNTNNYNNNDNDNNNNNNNNNNNNNNNNNNNNNSNNSNNNNNNDTSLYRYRSYGY
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Regulates the TSO2 subcellular localization. May be involved in nucleic acid binding.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The PCI domain is not sufficient to efficiently mediate CSN complex assembly and for biological activity.
Sequence:
MDIEQKQAEIIDQLVKRASTCKSEALGPLIIEATSHPSLFAFSEILALPNVAQLEGTTDSVYLDLLRLFAHGTWGDYKCNATRLPHLSPDQILKLKQLTVLTLAESNKVLPYDTLMVELDVSNVRELEDFLINECMYAGIVRGKLDQLKRCFEVPFAAGRDLRPGQLGNMLHTLSNWLNTSENLLISIQDKIKWADNMSEMDKKHRKEAEEGVEEVKKSLSMKGDVDIRGNKEMFGEPSGVMDYEEDGIRPKRRRHPVTR
The following text describes a protein:
Function:
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Required for elongation factor Tu receptor (EFR), but not flagellin-sensing 2 (FLS2) signaling.
Subcellular Localization:
Endoplasmic reticulum lumen.
Domain:
The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
Sequence:
MGTTTNLRSWLYLILLFIVVVGVNAQNRRPKNVQVAVKAKWQGTPLLLEAGELISKESKQLFWEFTDAWLGSDGDDSDCKSARDCLLKISKQASTLLAQPVASLFHFSLTLRSASPRLVLYRQLADESLSSFPHGDDPSATGCCWVDTGSSLFYDVADLQSWLASAPAVGDAVQGPELFDFDHVHFDSRAGSPVAVLYGAVGTDCFRKFHLSLAKAAKEGKVTYVVRPVLPLGCEGKTRPCGAIGARDNVSLAGYGVELALKNMEYKAMDDSAIKKGITLEDPRTEDLSQDVRGFIFSKILDRKPELRSEVMAFRDYLLSSTVSDTLDVWELKDLGHQTAQRIVHASDPLQSMQEINQNFPSVVSSLSRMKLNESIKDEILSNQRMVPPGKALLALNGALLNIEDIDLYMLMDLAHQELSLANHFSKLKIPDGAIRKLLLTTPLPEPDSYRVDFRSVHVTYLNNLEEDDMYKRWRSNINEILMPAFPGQLRYIRKNLFHAVYVIDPATACGLESIETLRSLYENQLPVRFGVILYSTQLIKTIENNGGQIPSSDAVTNAQVKEDLSTMVIRLFLYIKEHHGIQTAFQFLGNLNTLRTESADSSEADIEQEHVDGAFVETILPKVKTLPQDILLKLRQEHTLKEASEASSMFVFKLGLAKLKCSFLMNGLVFDSVEEETLLNAMNEELPKIQEQVYYGQIESHTKVLDKLLSESGLSRYNPQIISGGKNKPRFVSLASSTRKGESMLNDVNYLHSPETSEDVKYVTHLLAADVATKKGMKLLHEGVRYLIGGSKSARLGVLFSSSQNADPHSLLFIKFFEKTASSFSHKEKVLYFLDKLCLFYEREYLLKTSVESASSQMFIDKVLELADEYGLSSKAYRSCLVESVDEELLKRLTKVAQFLSWELGLESDANAIISNGRVIFPVDERTFLGQDLHLLESMEFNQRVKPVQEIIEGIEWQDVDPDLLTSKYFSDVFMFVSSAMATRDRSSESARFEVLNSEYSAVLLGNENATIHIDAVIDPLSPTGQKLASLLQVLQKHVQTSMRIVLNPMSSLVDIPLKNYYRYVLPNTDDYSSTGFDVDGPKAFFANMPLSKTLTMNLDVPEPWLVEPVIAIHDLDNILLENLGDTTTLQAVFEVESLVLTGHCAEKDHEAPRGLQLILGTKNRPHLVDTLVMANLGYWQMKVSPGVWYLQLAPGRSSELYALKGGNDGSQDQSSLKRITIDDLRGKVVHLEVVKRKGKEHEKLLVPSDGDDAVQQNKEGSWNSNFLKWASGFVGGRQQSMKGGPDKEHEKGGRQGKTINIFSIASGHLYERFLKIMILSVLKNTNRPVKFWFIKNYLSPQFKDVIPHMAQEYNFEYELITYKWPSWLHKQKEKQRIIWAYKILFLDVIFPLSLEKVIFVDADQIIRTDMGELYDMDIKGRPLAYTPFCDNNREMDGYKFWKQGFWKEHLRGRPYHISALYVVDLVKFRETAAGDNLRVFYETLSKDPNSLSNLDQDLPNYAQHTVPIFSLPQEWLWCESWCGNATKAKARTIDLCNNPMTKEPKLQGARRIVTEWPDLDLEARKFTAKILGEDVELNEPVAAPATDKPNPLPSNDISEDTEQDLESKAEL
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKRKLRHLTVVMSIYNKSDVHPSTFILIGIPGLEAAHMWISIPFCMVYVLALMGNSSLLFIIKTDSSLHEPMYLFLCMLAVADLVVCTTAVPKLLSLFWFHDGEIRFEACLTQIFLIHSCSTMESGFFLAMAFDRYVAICNPLRHSAILTHTVTGGIGLAVVIRGIALLSPHPFLLRWLPYCKTNIISHTYCEFMALIKIACAETSIRRAYSLIVAFLTGGVDFILIICSYVLILNTVFHLPTKDARLKTLGTCGSHVCVILVSYTPAFFSFLTHRFGHKVAPQVHIFVANIYLLVPPMVNPIIYGVRTKKIRNRFLKVFRFSKHTN
The following text describes a protein:
Function:
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Domain:
The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
Sequence:
MFQRLSSLFFSTPSPPEDPDCPRAFVSEEDEVDGWLIIDLPDSYAAPPSPGAAPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSSPLEDLLIEHPSMSVYVTGSTIVLEPGSPSPLPDAALPDGDLSEGELTPARREPRAARHAAPLPARAALLEKAGQVRRLQRARQRAERHALSAKAVQRQNRARESRPRRSKNQSSFIYQPCQRQFNY
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
Sequence:
MMQTVLAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIYKHYASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSALMAHDDLHAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVVDKAKVLSLAAVQLHGNEEQLYIDTLREALPAHVAIWKALSVGETLPAREFQHVDKYVLDNGQGGSGQRFDWSLLNGQSLGNVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMKSSKVSTILLLLFVVIIGSFCLTYGAPSTTNQKPLTSSEKKLLNDLYDRAKKAGGVVEFKSNLDSKKFVTAQNRPYDLLALFTSSNPKYGCSGCVQLKNQIESFSLSYEPYLNSAGFLEKPIFIVILEVDYNMEVFQTIGLNTIPHLLFIPSGSKPITQKGYAYTGFEQTSSQSISDFIYSHSKIRIEPVKTFYEKYSVQILSFVVFLASVRFLITAYRKRKSPMFWYFLTILLFACVIMGIFYDFIHKPNFYEFDHRQQTYNYFSRGSRSQTVSEGMIMGVSTIAITLIFVFLSDILPNYTNFSSKSKGLLFFMGMSSIIVLLFFQSLAFQIKYYRPLFFIPSVTYHY
The following text describes a protein:
Function:
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MDFLTASQSPSAPPAMDLEEPRDTLSPSQDLTPTCQWDPVPASSGSLSQMELDGPSVQDLVQQFEALPGDLVGLSPDGRPCPLHVATGHGLASQDVADAHGLLSAEAGREDLLSLLQCQECPPSQPCPKEPPDPAPRLLQPPEDPDGDTSAPEWAEGASAEQGGSRSSSSSPEPWLETVPLVAPEEPPASAQSPKTLVPYPALQEVPGPCDHEDLLDGVIFGAKYLGSTQLVSERNPPPSTRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRVKVLTADSQEAMMDHALQTISYTADIGSVLVLMARRRLARRPASQTRSRRLYKMLCHVFHSEDAQLIAQAIGQAFAAAYSQFLRESGIDPSQVGAPQSQGAAGPGHLHNGDLDHFSNSENCREVCIEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVREVKSQTLVTLSIIHCPPVTTAIIRRPHAREQLGFCVEDGIICSLLRGGIAERGGVRVGHRIIEINGQSVVATPHARIIELLTEAHTEVHIKTMPAATYRLLTGQEQPVYL
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
Subcellular Localization:
Cell membrane; Lipid-anchor. Membrane, caveola.
Sequence:
MARFVVAGASEYLAITGWGIDDVKLAKKAWVFAGQKCLKFDATPVSYDIDVQAMSSEKLPFRLPAAYTIGPSPKIKRNPVVDGPAPPADTQRRLEDCDEEALLLYAKLIAASQIRSPNHVIDLVKGVIEGETRVLASSMTMEEIFQGTKKFKQQVFDQVQLALNELGLYIYSANVKQLVDDPDSPGNDYFSFLGQKRQAEVEGKAKVAEAEARMKGEIGAKEREGLTLQNAAKVDAETKVLSARQQGVGCREEIKVKADVEVYENEREADIAAARAALAVKKAGLDKQSKVAEVEAVKAVVVREAELQLEVERKNALRLTEKLKAEKLSKATVQYETQVQDSNAALYDRQMAADATLFEQVKSAEARKAQAGAKFFEQKLAEDARLYARQREAEALAGVGRAKAELVASMLQELGGDHGALRDSLMIDGGVYEEVARVNASAMSGIQPKISIRSRAGGANAGASSAGAVQQVAAADVYDMLPPFLQSSGGFNKLPL
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MYLCNIKLTGKDLPNSLPERVKNEVSSMVDIISFNIGEDGPNRQTPASNAPKFNEQPTIQQPQPQQSNSQLLNTLVTQPTGFGQQPMVMQPTGMQPQQTGFGQAPGGYTGPRPSMPPMPTGYGSNLAPNQTGMAPLNAQPTGMPGQWGLVNNPASGLPNIEALAARMMPQTGREGGNHTTAGLTGNATIPWAITKGEKKLYDDTFRAWDGMSKGYISGAQALEIFGQSGLPKPDLERVWTLADSTDRGRLNLDEFAVAMHLIYRKLNGYPIPARLPPELVPPSTRNINDSIGAMKNLLRGDAEDRKNSGAFLQPQRTGVSYLKSHSFRAGSPAAGGRKDATVFRNNDENVGYKSSARHRLGGGGRSPSPAQPASPSSERSDEMSLDQLRKSVKEKQILLDAMDTRDENAADEEDALDRRDRREAEDLYRRIRRIQEDIDAHPKASLRSNDSDAERRALKRQLQTLTDRLPELASNVRRTEREIADAQLELFRLKDAKAHPGSSATIVGTGPGGAVTESDRLKARARAMMQARSAALTGRPAPAADDSGAATERLEKENSRIRSEKENNERMIRDVEDSVKEYTKSLESSLKEGGHDNTSEHERRRWEEALGVEDEVKDFIFDLQRSSRASRIRKEDGGSYASYKTPEERAAFIKQQAEQRMAERLAALGIKAPAKAGETPQQRAEREKKEREEKLRQAEEEDARREEERQRRLNDESTAPPAPVQGSGKKPAPPPPASRKNKADVAQHDVNQADAEAKRAENEMAEKALREQQEAQEAETKRLDYTRDEERRQENDLATEREAAQARLRALEEQVQQGKLKKAEEKKRKAAAQKEQKEQESRLAAQRAEIEAARERERQLQLQLEALDDDDSSDDEGPQNITPQDTTPTASQELPRESAPPPAPPMPVHQNTPPSSVASPPASSLTSPHADTETKNPFLKKMALNNQESTATPPPPPSNTSEVSTNPFHRLTQENANKAATPTFNEPAAPSSRRMGRQEDDDWSVVDSDDSSSDDDEGPTQGGAKQLASILFGTMAPPRPLSSMDNKSPRAESPAITSPPAGIPPPPPMPSGSAPPPPPGPPPPPGGAAPPPPPMPNMKAPGGPPNRGALLGEITAGKGLRKVETKDRSTASTAGRVLG
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MITLGHLLGLGAVLFCISLAGIFLNRKNVIVLLMSIELMLLSVNVNFIAFSRELGDTAGQLFVFFILTVAAAEAAIGLAILVTLFRTRRTINVAEVDTLKG