lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2. May be involved in cellular senescence (By similarity).
Subcellular Localization:
Cell projection, dendrite. Perikaryon.
Sequence:
MQAMDPASRGFYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCLECSLSMRSVAHAAIFQTLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDLTGNTFEAHIYSLGATLKAALEYVPEPELEPKLSTDLEGLLSQMQAEDPRERPDLASIIALCEEKMQPVSSCRLCRSLSAIGRRVLSIESFGAFQELSENTWRGRPAPRNVGPKKMPGDLSTDPEALFPSKGLLQPPASRDAEQEAGQRPRAPSPKPLLSAPVRNGENPGQEGLADLVLDARCPLGELDRDNLRRSRLKKAQTFPRLLQESTETSTLCLSLNGSRNQLAISEFFPPDPRKLFLEGKNGLSGFKTQSKSRLWPEQEPGVQLDKTPGAGRNPHRSPGASGQLEASSPSQGSVEYKPSPSPVDAGDSDHEGHIPRSEEKIPEESRQPGSTATEQSLSLKDLLSKLGRPFREYELWALCLSCLSTLQTHKEHPAHLCLDNVLVAEDGTVFFGPPPANGAYNSLFLAPEVSEEKLVTEKASVYCVAAVLWTAAKFSVPRDHKLALPRRLKTLLLDMARRHASERPSAAEAIKVCSSYLLQRGMDSSKILAHLRASTCKVHPEEETIGLQNAFSVVELKSTTAPAPESSPGFLQVSNDTKLVAVPGPVPGLPPCCKEACELPAAFTSEATHFKPIVLAQDASVTRDQLALPSESNEKPKEGSGHLDREGTRKQAALELVEATDLKMSNQLSPGPELQGATPDPDGDSGSPSSATECSCPHGPALVTQQKGTSGTPSSPASSLPPEHRPDGEGPLGTTVLPGPTSASQGSRHPCKPPRGKAAASPSSPRGSDGHPEKPRPADRKLCPSSVDTSSPPKMTACPSLQEAMRLIQEEFAFDGYMDNGLEALIMGEYIYALKDLTFATFCGAISEKFCDLYWDEQLLKNLFKVVNGPASPSESTSEEPGSQPEHSPSRCSLSSKRPSLHGLGKEKPATTWGSGGPCSPTALSDIDSDTLSQGNFEVGFRSQKSIKVTREQQPEAEVGGQPGPSQDSTSHASDTVARLARSEDGGPAGSPGASDFQNCSPGWSSAFYEADCFGADVYNYVKDLERQKTNGHTELEAQSPELEQQLMIEKRNYRKTLKFYQKLLQKEKRNKGSEVRTMLSKLRGQLDEMKSKVQFLSLVKKYLQVMYAERWGLEPCALPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGSGRQKKARILQAGTPLGLMAYLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRISSTLSRAHQDPTSTFTKIYRRSLCVLQAWVEDCYTVDFIRNAGLLGQLEDFISSKILPLDGTAEHLLALLEVGTERRADSASRGADLEDPKEAEEDTRPFNALCKRFSEDGITRKSFSWRLPRGNGLVLPHHKERQYTIASALPKPCFFEDFYGPYAKASEKGPYFLTEYSTNQLFTQLTLLQQELFQKCHPVHFLNSRALGVMDKSAAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILGGLEHLAVRQSPAWRILPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVASQVHAFQENPYTFSPDPKLQAHLKQRIARFSGADVSILAADNRANFHQIPGEKHSRKIQDKLRRMKATFQ
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
Subcellular Localization:
Cytoplasm. Postsynaptic density.
Sequence:
MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRMPRRISLRKVRVQNSESFSAEKALVEGYNFVGIPLVRSPSLPATISGALTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQDGGSYQIRETFSASSVQPNQDLEAELQDKEKEEGLLPDTLPKSSSTLMMAFRDVTVQIDNKNISVSSSTSVSMANCLSSNAQAGLSQASKSEESPGEGEGEDSEPQAAPECLPETEALQNSHTFTEVNISTNGMGDSNEEPGQMAVQKLQFDANNETGQSKGSESENADNSEQLSSSSTSTSAKSASEVSSKEALQAMILSLPRYHCENPASCKSPTLSTDTMRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSGMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPDVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLYEVTDVNKVQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFHLFENEYYPHGITLVTPVSGSEKKQVLHFCALGAEEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGAKTLSLRSNGAQIEPQSKQSSPTGKKDLGEKVSDSTVEVLINASPARLTILPISRDTIKSYC
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
Miscellaneous:
MISCELLANEOUS: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRVSVSDPLPFSAPLAAGGEALSTSALPAGVRDVLPAEWERREHLRSHLSALLRSWGYRGVDLPALELADPAHPQGNHAFKLIDSGGQVLALRSEYTTALGRLVGTHFPSGPFPLRLQYGGRLWLRTQTSELGRLREFNQVGAELIGVTGVQADAELLALAHAALGQAGVQAQLEVGFPGFVDAALTDAGLPGPVRAALHDAIDRKSGADLDLLARQHGVSPEVTRTLHSLTELYGGPEVLTEARVLARGVRAEQAVEHLSAVHAAAQEAGVELLFDLGVSRRYGYYTGLTFRAYVDGINQPVLGGGRYALPGGLPGAGFAIGLERLAAVMPAGVPSEPETVLALDFAAATAARAAGLGAELAWTGDEAELRHYAQARGLRRWVQGAELRDVTPADLKIATEVNA
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MIITIKNLQQQTFTIEFAPEKTVLELKKKIFEERGPEYVAEKQKLIYAGVILTDDRTVGSYNVDEKKFIVVMLTRDSSSSNRNQLSVKESNKLTSTDDSKQSMPCEEANHTNSPSSTNTEDSVLSRETRPLSSDELIGELAQASLQSRAESNLLMGDEYNQTVLSMVEMGYPREQVERAMAASYNNPERAVEYLINGIPAEEGTFYNRLNESTNPSLIPSGPQPASATSAERSTESNSDPFEFLRSQPQFLQMRSLIYQNPHLLHAVLQQIGQTNPALLQLISENQDAFLNMLNQPIDRESESGATVPPVSNARIPSTLDNVDLFSPDLEVATSAQRSAAGTSAAHQSGSAADNEDLEQPLGVSTIRLNRQDKDAIERLKALGFPEALVLQAYFACEKNEEQAANFLLSSSFED
The following text describes a protein:
Function:
Probable transcription activator that may act as growth regulators in response to water deficit; Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MFNLTNNFETPPSFLIWGINKTPRETSTRLQPPLGHILLKSYMLDMGSDPYSECSFTAFFNNKNNNKIQRRFTNQQIESLETIFQTESKLEPRKKLQLAKDLGLQPRQVAIWFQNKRARWRSKQLEKDYNILKASFDSLSSRYDLLNREHQSLTHQVNKLREGIEKKAKSCSTGETSNNSMEEKVSDADSNMKQEYIEDEKMNNNNNNNMGFVENCKNVECWDDLECDQWWDLWS
The following text describes a protein:
Function:
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production.
Subcellular Localization:
[Isoform Alpha]: Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane (By similarity); [Isoform Beta]: Cytoplasm; [Isoform Gamma]: Cytoplasm.
Domain:
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Sequence:
MDGSGEQLGSGGPTSSEQIMKTGAFLLQGFIQDRAGRMAGETPELTLEQPPQDASTKKLSECLRRIGDELDSNMELQRMIADVDTDSPREVFFRVAADMFADGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLVWIQDQGGWEGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
Sequence:
MPIRLLDETIAAQIAAGEVVERPASVVKELLENAIDAGAQRIVIEVRGGGLREIRVQDDGCGIPADEIELAFARHATSKLQSADDLWAIRTLGFRGEALPSIASVAQVICISRVADAELGVELRIAGGEVQSRLPCGCPVGTTITVRNLFYNTPVRREYLRSEATETGAISAIVQQYALAYPEVSFSLLIDGRMALQTSGDGDLRTVVVELYGLEVGRALLPVQAEAGVDETWVAVNGLISPPELTRSSRNYLSLFANRRALQPRGALAAVVENAYHTMLMKGRFPIAILDVRVHPAAIDVNVHPTKSEVKFRYAAHVHSVLGRAIRDALLRGADIPTWDAPDPATAQRRFELRRLGQVATTPSSGWSVGASAWDRERSRWDVGSPATALNTPLPIVPEAPQSPPSPTLVPEPARQTPGEPITPAVPAAAPSALPPLRVVGQVGLTYIVAEAPEGMYLIDQHAAHERITYEKLMNQYAQHAVESQQLLIPQAVEVSPEASALLLGNAERLAEWGFVLEPWGTGVLVRAIPATLPTDELTQAIHEIAEKLAGRGGSDPLEWREAMLITLACHTSVRAGQPLSHEEMRQLLRQLEQCVSPRTCPHGRPTMILMTPAQLERQFGRRV
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLHVIRRSRATSARQLPRVAGLLAGAAAVRSRTYIGTRILHEEQKPKKPEPPNSILTEDMLARAGVDAERGPETEKAPAEDKAGESTETGSGAGKKKRARKTTTEIKRERYANLFYLFSLTGLAGGAVYMSRDWDADEPEEERKGIENGYTPGLMYRRFKARFDSLFTFFQEPPYPDLLPPPPPPPYQRPLTLVLPLEDFFVHSEWTQQHGWRTAKRPGADYFLGYLSQYYEIVLFSSNYMVYSEKVVEKLDPIRAFITYNLFKDHCVYKDGIHIKDLSHLNRDLGKTLIIDTDPNSVKLQMENAILAEPWDGKADDALLRYIPFLEYLVTQPINDVRPILNSFKDRHHIPEEFAERVEKLRAKFNADQKAKAGSGLSFLLNPGMASKPAKFPLDLIREEGEKNYVRFMKLIEEEKEKLKLQQEHMSAPTFTLKDMAEGNMPTPEEQMKMQLQKQKEFEELYEKEKQKMQQQTKGQ
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Sequence:
MENQATIKKGRRAKNFTPTEVEILIVEVENRRNILFGPLKGPSLTQYHRDRAWDQVLSHVNSVAPCVRSVGELKKKFKDLKSRTKSRANALLRESRKTGGGENDAAPLNAFEEKMLTFVGKESVEGIRGGIDTFAFCKVESHDPVPPRPVSPPPRTLSPPQYPLTPSPRHLTPPPRLPTPPPRLPTPPPRLPTPPPPLPAETPAPQVQKKKFTKKSALDEIKKTSALQAETNVLLGQLVAEIRESRKEINMLVNLKKRELEIREEELAIKKKKI
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex. When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids. Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components. Links the microtubule cytoskeleton to chromosomes during interphase. Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase.
Miscellaneous:
MISCELLANEOUS: Present with 996 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Sequence:
MSEQSQLDDSTIDKLIPQIFNEMRSNLNNTTNKFPKSTGGGASDNISANSNSIRSFNSITTQSLLKESESLDKITAMIKNVTAALKNNLPVYVNQVHEVCKSTNSILDSWINIHSQAGYIHKLMSDQTYLKLINDRLHNENVNTNDEDGSTLHNVIALKKKEILDLRQKLENRKGEKDAAPAKPPNQGLNPRYGVQSGRRPVPSAGISNNGRVRKTHVPASKRPSGIPRVTNRWTKPTASSSRKMFR
The following text describes a protein:
Function:
Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.
Subcellular Localization:
Secreted.
Sequence:
MPSAFSIQLAWFCALTISLAISPAWLQKPPKRKVVTGNPKAASCCEELKEMKAQVANLSAWIEEMSKKQDAELGSAIVQVIELEGSLKRMDLRLNDVEGKYSEMNNQLGIVQLQAAQTVTQTSADAVYDCSSLYQRNYRTSGVYRLLPDEFLGTPELQVYCDMETEGGGWTIIQRRKVGLISFSRDWKQYKQGFGSIQGDFWLGNEHIHRLTMRPTMLRVELEDWNGNTRYAQYSQFVMSNELNSYRLFLANFSGNVPHDSLRYHNNTAFSTKDKDNDKCVDHCAQLRKGGYWYNCCTDSNLNGVYYRNGEHNKSTDGITWYGWYGKTYSLKRVEMKIRPTDFKAQGDTNKVE
The following text describes a protein:
Function:
RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, P-body.
Sequence:
MNIPRFMPGHVLHTSEDIPQSESPLAGRRTRPVSEAFSSSYRHSDLGGYPPYGLGGSATAGLGSLSAGMGNLNLGGTTPGLQHLGGGLANTATMDSEKWLQDLELYNAILEEMATVSLDKDFKDELSSIEQWFGVLSDGERTAALYALLQQTNPVQIRFFITVLQKFGNMDFDGSPIGNSFENGAPQQQQQTSAQPSPMGQGAMGQAMTGGLGGLGGLHPHQTTHSNLNPNAHNPIYAPVGTFPSTPSHKHTSSLSTEPIGSRRSMIATPEHDLNAQIANTTAMKLAALSTVSNRASLDDRSKRSSFHQHTNSQESTPTKPGTPGGSPAPGAHSLATPMKGHHQTSSSSSITQLSGASSASPATDIKLLRDVSAWLRALRLHKYTECFKDMEWQDIVQLDDAQLEEKGVNALGARRKMLKVFEQVRDAQKDGTLGGV
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MPGFVAHRPAGQFGKRLTILSVDGGGVRGLISATVLAELEGQLQRLDGPEARLVDYFDVISGTNFGGLITSMISSPRAEGSNRPLFTAREVVQFFQTHAYEIFPQGRDPSGQTRRNFMALKGPKYFSRGLRHLLDQVFESDPLLDRALTSVIIPAFDTKLQQPILFSSWQARRDPLENPPIKTVCCGTTAVPTHFPPIHFTLTDTSREPNQTREFNLINGEVAVHNPAYVAIAQAIKESHADGTVAKRVDCSNLNNILVLSLGTGQHTMGYDATNVAKWGTVEWLDNNGEARLVDTVFNAKGDMVDYSLSILFQSQHCASNYLRIQADNLNGPLASLNDTSESNLRNLTAAANRLLDEPASDRDYQTGKVHPDLCKTNREALKRFAGWLSAERNTRFAAEPPPAPVKRAPPPVVMESPLEAARPQTAEEKPSEELAAPAAEEIKPKPPVAAATEGQVLAPKVKSKPIDEGITVTKKERKANAYVIFPYVPRAAYFDESVNTQRVNTSYVPYSEPAYRATYSNDHTSSYNSGRRTSHNPTSRNPSSRNSSYSSSSYDTSNRVPSYIPSLFDDTYRRSPYRPVSDDHTYSTSYPDSSYETPFSSYSRPSSYGYSQAHQSYGGSSSSSHTSSRGSHSLDPRYDSSAYRPSYAPNTAVTASACERPSYESKSTSFAATPEPTQRASYGNTHSSSSSSYSLPPYRNSSWAGTDASGSRAVPDLFRFFS
The following text describes a protein:
Function:
Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.
Subcellular Localization:
Nucleus.
Sequence:
MSCIFCKIVKGDIPCVKLAETALSLAFLDIAPTSKGHALVIPKEHAAKMHELSDESCADILPLVKKVTKAIGPENYNVLQNNGRIAHQFVDHVHFHIIPKPNEEYGLGVGWPSYPISPEEIKALGEEISSKIK
The following text describes a protein:
Function:
Involved in sporulation. Plays a significant role in modification of the spindle pole body prior to spore formation and is required for initiating forespore membrane formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MMSNSQISKLFSSISNKENSNENALKESTNKQLNNANTLAITHLKEQLSREVQRREELEGLLEQSQKEMEDLSVSLFTEANEMVAKARQDTEVLKRELDYLRAKEKGRIGKLRSIQTAVRTSIEARKLLSYSNESNYH
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MSAPIVDAPAAEIVYKIISSDGVVSKMSEKAVQQSKTLSNLIENLGYTIENIETRDPIPVTNVNGKTMAKVAEWCEKHKADAIPEDNMNVLKTLTIPEWDQKFLKIEDEALFDLILASNFLDIKGLMYFGCKTVSNMAKGKTTAELREIFGINTDEQDAAEETAQRAAAEVA
The following text describes a protein:
Function:
Chaperone that may play a role in mitochondrial protein folding. Involved in female gametophyte development. Required for cell death of the synergid cells during fertilization process, and fusion of the polar nuclei during megagametogenesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MVPSNGAKVLRLLSRRCLSSSLIQDLANQKLRGVCIGSYRRLNTSVGNHANVIGDYASKSGHDRKWINFGGFNTNFGSTRSFHGTGSSFMSAKDYYSVLGVSKNAQEGEIKKAYYGLAKKLHPDMNKDDPEAETKFQEVSKAYEILKDKEKRDLYDQVGHEAFEQNASGGFPNDQGFGGGGGGGFNPFDIFGSFNGDIFNMYRQDIGGQDVKVLLDLSFMEAVQGCSKTVTFQTEMACNTCGGQGVPPGTKREKCKACNGSGMTSLRRGMLSIQTTCQKCGGAGQTFSSICKSCRGARVVRGQKSVKVTIDPGVDNSDTLKVARVGGADPEGDQPGDLYVTLKVREDPVFRREGSDIHVDAVLSVTQAILGGTIQVPTLTGDVVVKVRPGTQPGHKVVLRNKGIRARKSTKFGDQYVHFNVSIPANITQRQRELLEEFSKAEQGEYEQRTATGSSQ
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MATKAAIGEEPEIEKKVCITPVANSIQLPQKIDISVIDHETPKKNFKQKTLQILLMWLFCKNQVNPLWLTVTNKHLIRCCVVMNLNFALDLSSSQYLSSFSQKDKIVQFKQMDQGNVNFWQSVFYTKYHEDQASQTQNQQQMNHQDILQEHLIYNQYRNLILNKEQLKMNLYPIDEKIYHDYVRLDGKKGQKNRMNIFAIDCEMVQTENRLELARVSIVDYNYRVVLDILVKPQTIILDYNTKYSGITEEMLSNVTITLAEAQKMVKSILDEESILIGHSLENDLNALQMIHHKCVDTSVLYMTESNRKQSLKNLAHKYLNLSIQKDTHDSNEDAKIALSLAKLRIEILNHFSSASFPQQQTATPDVLIQLRKFGGIHLVDSRQEVELLLKYDVGFEDGEQINDEKKMKRMIELLKQRSANAVNPKLIFAQIQNKFQEFESLFLTMYNLAPSQTMFILSIGGEQQQILLITK
The following text describes a protein:
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Domain:
The phosphatase catalytic core motif (or RXNCXDCLDRTN motif) from the SAC domain is found in metal-independent protein phosphatases and inositol polyphosphate phosphatases.
Sequence:
MTSSPSVENGGSGSSGSSALLGCMQQFKLFETQANFYMIGWNGSGVYRILKIDRLEASELNLREDSTAYTKKECYELLKRIHEGNKATGGLKLVTVCYGIIGFIKFLGPYYMLLITERREIGEICGHIVYEVSKSDMIALQHSSVLCNTANLRDENRYKRLLCMVDLTKDFFFSYSYNIMRSFQKNICDHESGGTLYKKMFVWNEFLTRGTRHHLRNTLWTVALVYGFFKQTILSEAGRNFKLTLIARRSRHNAGTRYLKRGINESGNVANDVETEQIVSEDVPVDRPMQISSVVQNRGSIPLFWSQETSRMKVKPDIVLSKRDLNYEATRVHFENLVERYGVPIIILNLIKTNERKPRESILRAEFANAIDFINKDLPEENRLRFLHWDLHKHFHSKTENVLALLGKVAACALMLTGFFYYQLTPAMKLEGYMSLSSSDADTSPHNSSDDDSRDYDSLEKNCRPSKNVANGDYDVKPSRLQSGVLRTNCIDCLDRTNVAQYAYGWAALGQQLHALGIRDAPTIELDDPLSSTLMGLYERMGDTLAYQYGGSAAHNKVFSERRGQWRAATQSQEFLRTLQRYYNNAYMDADKQDAINIFLGTFRPEQGSQAVWELRSDSHSNGRSGEISMGEDEKFLVKRCLSDGNILHESHTPMSAMSRKNESISHRGFVSSHQVTRTHIISESSPDMPAAGDVTLSRCTPSMPSTHFFGDVQKVQHNGSSSIYLSEQEDMSSVSNFVDIEWLSSSENLCENDHLSRPSALTIYSTAETSSSENIITEVKQLTPAMRESGSSSRKGKEPVETELSVHTKIRDDFPDSFKQWVAYGEALCH
The following text describes a protein:
Function:
Involved in histone pre-mRNA 3' processing and couples histone mRNA production with the cell cycle. Both maternal and zygotic proteins play an essential and vital function for development.
Sequence:
MLCEDQHMSVENTPQKGSGSLNSSASSISIDVKPTMQSWAQEVRAEFGHSDEASSSLNSSAASCGSLAKKETADGNLESKDGEGREMAFEFLDGVNEVKFERLVKEEKLKTPYKRRHSFTPPSNENSRSNSPNSSNSSANGDAAAPKGGNNPHSRNSKKSGNFRAHKEEKRVRHNSYTSSTSSSSSYTEADPAILSRRQKQIDYGKNTAAYERYVEMVPKDERTRDHPRTPNKYGKYSRRAFDGLVKIWRKSLHIYDPPTQARDTAKDSNSDSDSD
The following text describes a protein:
Function:
Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQTFRLTSTGRNILRPDELAFQPREEIPYKSFHPDLQIDEPLEILEGDHTQYAGLRDSLVTYKSENSYVLKALLNAKIENVKPVGVQTENINPQEKKFGYKTAKQLDWSPDEYFKFVAIHPYSKTSFPVSYDLDELDTMWLTYYNEFQLSSNSEWENVSKEFLEIVLTIIEREWLYLEAWMPKIEPVRVEDELDGRCVICNEAECENSNAIVFCDNCNTSVHQNCYGIPFVPEGQWFCKKCLLAPHEVICCAFCPDRDGAFCTTLDGRWCHTICAIAIPEISFHDTSRLDLVRNIASIPKSRWKLVCCICKLRWGTCVQCSDKNCYAAYHITCARRAGFFYKIYSHSASYDSVDMETYCDKHTPPDYLNGLMKRLFPLAELYYKRMATDVPLNFQATKAPDFVPEGPWKSHPLPAFIVDKVTKVLLSYNVKRQDLPSIVTDICKFYHMKRRSRKDAPLLKSQLLMDSLENLPVRASKDRVRSLEVAKALQDQYQSLLTLVESTAKRQLLKCQLSNLRKKFLNLNYFPAQRLLQDTLVKIIDLDVDGLFNMPLDNGWIGWVELKRQVFSYQIGSISSLEKKLEPIWDVDGVIQCIDDMEQLTAMVQFAQKTEGEVKKLFIKAKIYFESLSLDERGNLKVPSLGINGLEYDNWPGLNELEMSQLDIPSQGNLKSLHDFIEGLDLNEKIGKFPISMFQNQVAQFSTIEIPKMSGRANGMHNFHSEDVTGQSNHALPNSVTKKNGTKQPYTKNSLPFNERITRSKAKKNYS
The following text describes a protein:
Function:
Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Vacuole and punctate structures.
Sequence:
MSYGTINDMNESVTNYRIKKAQNNIKGWYAYSFSSEPFVVSAVSTYIPLLLQQFASINGVKVHDHSIPCLSETGSDSDKCVLGLFNNRIFVDTSSFALYVFSLSVLFQTIIVISVSGIVDLWGSVKFKGRILVWFGIVGALSTVAISKLNDTQIYSLAGLYIVANGCFGVINVVGNSLLPIFVKDSLKCQSQGAYEPDKVDSLTTVISGRGASLGYSSALIVQIVSMFLVASKKGSKQDVQVAVLFVGIWWFVWQLPMIWLIDDVTIPIRVDDSTLASARSPYPGEQDALGQLNWKNYLSYGWVSLFESFKHARLLKDVMIFLIAWFIISDSITTINSTAVLFSKAELHMSTLNLIMISVLTVVNAMLGAFMIPQFLATKFRWTSSQTLMYIIIWASFIPFYGILGFFFNAFGLKHKFEMFLLAIWYGLSLGGLSAVSRSVFSLIVPPGKESTFFSMFSITDKGSSILGPFLVGLLTDKTHNIRYSFYFFFLLLMLSLPVLNCLDVKRGRREAEELSQVLPESERRLD
The following text describes a protein:
Function:
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. IliB collaborates with the hybrid PKS-NRPS synthetase iliA to assemble the backbone of ilicicolin H. The PKS portion of iliA and trans-acting enoyl reductase iliB work together to construct an octaketide, and two methyl groups are introduced by the MT domain of iliA during the chain assembly. The nascent chain is then condensed with tyrosine, catalyzed by the iliA C domain, and the resulting PKS-NRPS hybrid is offloaded by the iliA RED domain to form an advanced tetramic acid intermediate. The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain. The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone. The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H. 8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (Probable).
Sequence:
MALATPLPATQAAVKVTGPSTVDVSAATTLPVLEAFEVLVRVACVSINHVDGKSADMSPTPGATSGVDFSGLIVALGSKVDSDEFRANNNMRALSIGDRVFGGVFGNNPLRHDNGAFAEYVAVPARLIWHMPAAMDFSTAATIGATLATVGLALFQYLQVPMPSTQTISDSKTIPDPQQKTRMALVYGGGTATGAMAIQVLKLAGFRPITTCSPGSAARAMHLGAAATFDYRSPTCGADLREHTANGLELALDCITDTASMSICYEALGSAGGRYVALDAFPLRGHTRRSVAAEWVCTYTQFGHAVAWVPPYNLDARPRDREIAEAWYVVAQQLVDEGLIEPYPKEDRTGGLAAVGEGMRAVWKGEISGRKLAYPIAEECY
The following text describes a protein:
Function:
An alpha subtype methylase that recognizes the double-stranded sequence 5'-GGNCC-3', methylates C-5 on both strands, and protects the DNA from cleavage by the MjaII endonuclease.
Sequence:
MNLDAWLDIQPAKKLYTIKEASRILTKKFGKEIKEHNISYLVQYGRVNKYKIKNRVYVDIDEVENYYKKLFFEKRKEWEEKLGFKLDWDLAFDLLSEKERTKHVHGIHPYKGKFIPQLVEYFLKRHFNVGDIIIDPFMGSGTTLVQCMEMGINSIGIDISPFNCLIAEVKLQKYDIQKLKKILLDMLNKTKEFSKNLGDDEFVKEMDKLIEKYNKKYFTLEYKRKLSKKEIDEDSYSEKIMEMFYLEYKKLKEKYCKNDDEFDDIFKDKPFLYKWYSPRIRAELNFYLNLIKDCRDETIKKVAMIILSRTARSVRGTTHFDLATLKEPVFDPYYCYKHKKICRPVQTILRHLEEYTNDVISRIEEFSKIRKDAYYLIINGDSRTVDIEEELKKHPNFYELYKNKKIDGIFTSPPYLGQIDYHEQHAYAYELFDIPRLDELEIGPKFKGSSKKAQKEYIEGISDVLINMKRFLNEDAKIFIVVNDKKNLYKEIFEKSGLILVREFKRPVLNRTERDRNPYYESIFELKMEE
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSKGKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINKCTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKIIKYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLADRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MEGLSVADANLLMYLHPSKSRNVSQSILRELGSLLFKFNETFDGVLLAYDVNILDKQAKILSGVHPYFGLRLKANLLLFSPKPDMLLEGKVVKLSQESIHVIVLGFSSAIITAENIHGEFKYRTKDKEELFASKSHKRLVIKVGTMIRFLVKSFDEEILHIIGSLISTHAGSIRWLDRHLEEDSEFDRSSMKSRDREWLGDNHIKMSKKRRITE