lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the migration and outgrowth of muscles, axons and excretory canals.
Sequence:
MTTSNVELIPIYTDWANRHLSKGSLSKSIRDISNDFRDYRLVSQLINVIVPINEFSPAFTKRLAKITSNLDGLETCLDYLKNLGLDCSKLTKTDIDSGNLGAVLQLLFLLSTYKQKLRQLKKDQKKLEQLPTSIMPPAVSKLPSPRVATSATASATNPNSNFPQMSTSRLQTPQSRISKIDSSKIGIKPKTSGLKPPSSSTTSSNNTNSFRPSSRSSGNNNVGSTISTSAKSLESSSTYSSISNLNRPTSQLQKPSRPQTQLVRVATTTKIGSSKLAAPKAVSTPKLASVKTIGAKQEPDNSGGGGGGMLKLKLFSSKNPSSSSNSPQPTRKAAAVPQQQTLSKIAAPVKSGLKPPTSKLGSATSMSKLCTPKVSYRKTDAPIISQQDSKRCSKSSEEESGYAGFNSTSPTSSSTEGSLSMHSTSSKSSTSDEKSPSSDDLTLNASIVTAIRQPIAATPVSPNIINKPVEEKPTLAVKGVKSTAKKDPPPAVPPRDTQPTIGVVSPIMAHKKLTNDPVISEKPEPEKLQSMSIDTTDVPPLPPLKSVVPLKMTSIRQPPTYDVLLKQGKITSPVKSFGYEQSSASEDSIVAHASAQVTPPTKTSGNHSLERRMGKNKTSESSGYTSDAGVAMCAKMREKLKEYDDMTRRAQNGYPDNFEDSSSLSSGISDNNELDDISTDDLSGVDMATVASKHSDYSHFVRHPTSSSSKPRVPSRSSTSVDSRSRAEQENVYKLLSQCRTSQRGAAATSTFGQHSLRSPGYSSYSPHLSVSADKDTMSMHSQTSRRPSSQKPSYSGQFHSLDRKCHLQEFTSTEHRMAALLSPRRVPNSMSKYDSSAAALNASGMSRSMILLESLSPRPPRRHQSPADSCIITASPSAPRRSHSPRGPTARIPLSLASSPVHVNNNWGSYSARSRGGSSTGIYGETFQLHRLSDEKSPAHSAKSEMGSQLSLASTTAYGSLNEKYEHAIRDMARDLECYKNTVDSLTKKQENYGALFDLFEQKLRKLTQHIDRSNLKPEEAIRFRQDIAHLRDISNHLASNSAHANEGAGELLRQPSLESVASHRSSMSSSSKSSKQEKISLSSFGKNKKSWIRSSLSKFTKKKNKNYDEAHMPSISGSQGTLDNIDVIELKQELKERDSALYEVRLDNLDRAREVDVLRETVNKLKTENKQLKKEVDKLTNGPATRASSRASIPVIYDDEHVYDAACSSTSASQSSKRSSGCNSIKVTVNVDIAGEISSIVNPDKEIIVGYLAMPTSQSCWKDIDVSILGLFEVYLSRIDVEHQLGIDARDSILGYQIGELRRVIGDSTTMITSHPTDILTSSTTIRMFMHGAAQSRVDSLVLDMLLPKQMILQLVKSILTERRLVLAGATGIGKSKLAKTLAAYVSIRTNQSEDSIVNISIPENNKEELLQVERRLEKILRSKESCIVILDNIPKNRIAFVVSVFANVPLQNNEGPFVVCTVNRYQIPELQIHHNFKMSVMSNRLEGFILRYLRRRAVEDEYRLTVQMPSELFKIIDFFPIALQAVNNFIEKTNSVDVTVGPRACLNCPLTVDGSREWFIRLWNENFIPYLERVARDGKKTFGRCTSFEDPTDIVSEKWPWFDGENPENVLKRLQLQDLVPSPANSSRQHFNPLESLIQLHATKHQTIDNI
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MASATRHRPPDTSAVSFLLLDGAAMTQPSSSTAVAAHGDVPVVAFVGGGNMARSLIAGLLRQGAPASAIRVAEPVAELRQALSADFGVQVFDDARSAVEGAALWVLAVKPQVMSTVCTQLADLAQQQHPLLLSIAAGITATQLERWCGGTAAVVRAMPNTPALLGAGVTGLYANARVSAAQRTQATRLLESAGVTVWLDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAARAQGLPAETARTLVLHTLLGAARMLTESGEAPEVLRRRVTSPNGTTQAAIEEFQAGGFEALTATAIAAATERGRSLSAAND
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MLLRLPPSLHYPITVTSLLKQPGDEVERDEAIFWYAYQTIVTEGDGWGNKVDVKRTFPTRFESTVDGNIVQWKISKGDVIDGPVDVVEIDEPCAHEVQYGGLCAECGKDMTEATYNTEVPGSMRAPIQMTHDNTALTVSEREAIRVEEDAKRRLLANRKLSLVVDLDQTIIHAAVDPTIGEWMADKDNPNHAAVSDVRAFQLVDDGPGMRGCWYYVKLRPGLEEFLENVAEMYELHIYTMGTRSYAQAIANIIDPDRKLFGDRILSRDESGSLSVKNLHRIFPVDTKMVVIIDDRGDVWRWSPNLIKVIPYDFFVGIGDINSSFLPKKQELETPGENQEQNPTPPIQQQVNGLAEKSDATELSTLEQLVTMGGGDNPRLLQEQTEAQDVTILHQVEDRPLLQKQKELDAEDESADSRESGLNESRDSAKPRHHLLIDNDQELIKLSDRLEQVHRKFYEEYDQKRARGLGGRVAALRGERAISKEKDVDLKLVPDVKDILPAIKRRIMGNVHVVHSGLWKLNEDIANIELAQHAKTFGVVFADRITHKTTHLLSAGKRTAKFQEAMQRPKIKIVRKEWLVDSLLQWKHLDEGPYLVPTHPNEQRSSKEVAESSWLSSSDEASGDSFTDTEDASELNDEILKSAGINDLGFDQDEEAAVHEELKEFLGSDDESESDSEISWMERNELPPTSNPDKKRKREDGTDNDNDENNSDTQGSGEVAGSRLSQRIKRSYERSTGLKEVASATSGENGSNTDTGTATGTDTDTAEADDVPDVAFPETEEEGAASRNPDSSYPQDPAEEEDELEREMLAAFEEGGYDSNAEKAIGEDKG
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Subcellular Localization:
Mitochondrion.
Sequence:
MLGSSTSQLAPAMVRSIASSAAASTAAPVLAAKSGGLLASVFGMGGGRVEVPLSEKLPAVTEPPRTSTPATKPIVQTSSLRSGVKVASINTVSPISSLVLFVEGGAAAETPATAGASKVLEVAAFKATANRSTFRLTRELEKIGATSFARAGRDHVAFGVDATRLNQLEALEILADAVVNARYTYWEVRDSLDAVKEQLAAQLRNPLTAVNEVLHRTAFEGGLGHSLVVDPSVVDGFTNETLKEYVHSIMAPSRVVLAASGVDHAELTALATPLLNLHGNAHPAPQSRYVGGAMNIIAPTSSLTYVGLAFEAKGGAGDIKSSAAASVVKALLDEARPTMPYQRKEHEVFTSVNPFAFAYKGTGLVGVVASGAPGKAGKVVDALTAKVQSLAKGVTDVQLATAKNMALGELRASVATAPGLAAAVGSSVLATGKFSANEVAAALSGLTAADVTSYVNAMIKTAPTFVTYGNLSSLPRVDSIAKRFA
The following text describes a protein:
Function:
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies.
Subcellular Localization:
Nucleus. Nucleus, Cajal body. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Associates to transcriptionally active chromatin at snRNA genes.
Domain:
The N-termimus domain is necessary and sufficient for its targeting to subnuclear cajal and histone locus bodies.
Sequence:
MMPGETHSAAPGTAADLSRCQGCASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYARVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSYGSIDKRKVKLLLKELWLCVNTTHRLPGEGSRCVPEKPAKAITSSRVPGEDGTLPPTQGSPLRTSNVQTCLTKLSMEIKEDFLCQNVEKQSSSGTNCSSDHVFNENGNLEVLVQSHRDGGSTEFVDHDHFFDEDLQAAIDFFKLPPPLLSPVPSPPPMSSPHPGSLPSSFAPETYFGEYTDSSDNDSVQLRNSAECVSEDDTTESQNYFGSLRKNKGSGTWEEKPKSHEAIQALNTWEVNKVTTSGLETFTATLRESSATHSLVGEKHWTTASRSMSDRKRDILHETKTQMEVREMDKSVQTEKTIHKLTRGLCIERLSASPAQEKEAAPGKSELCSSPLGKRPLNELMESEGKTVLSKMMGSPKSEFTKWTRINEITSEPDRITVSGHFHRLSRELEKEKEDTQGFTLGESPESEDDDSGDGMDVAGLDIETSFSSSSTLVALSVGSNPQSSSGLDCGNDTDITTKVFSTEPHHSEHKLQTKTLNTLHLQSEPPECSIGGNNLENSLCALSPELGASNFNDQKSSGIEYTKVVKGLTKIHSLPRSVFMKATKDGQCESQDPRIELTLNKPDFTSLIGSQAALIKSGLGFVKSTSWHHSDLLRKGGEESLRAKSEHEQKTSHQLQKAMPFLQNRGPTPKPDLLRENNNPVEFKTTASVLPNQVSVITKQTRPEKVQSAKLEHLRPHRVEPTLVTENSGNKTGMSTVAKCDGERDDTTQNITEVAAVKSISPEVSASRRKLDFNSPGGSSPVENSDCSTNSRLSFSPENILIQNQDIVREAAVQGDGQKQRQPQATDLDSSGTHGSEMLPATEVTVSGGFSVEETSCGDTGRSGGEALAVANDSTSTPQNANGLWKLKSTTPGGALPECFGTTDTTFSSAFCRKHGETQDTSQSSLPGTLHCYTGIREGGDDTEVESEAFSCSEGSEQQDAPDDSQKNLGDTDAAVAEVRPSLEVGYLTSALQDFNISTFSELDRLSTSEVVMFLESCQLGDYSSGDSVSECSSKGTLSKEMNKELKASEIGEKYRKQPCEEETLGTCEEWIESEEDDYSLKNTSQLTQCSLETLSEVLTKIRQELQTNSEDCNGKDTGSLLLLNVNNNMTTENLKEKSPFRETTGSSSHASEPTPQAAALDTEGSSPISGMPQNENPQSRPEARSDAGRQTDGGEEDLPEPVEPSALCSDSVMEPSIEQSSNCEAETTFQCQIATVTSEVINVLINKDQNLVIEKGDNWTIISGVAVLPHVDQVTLCDIPGDIPISQDQGELEAGCIPVTSAEKSPEASHTGPAFQEAPCGNNLSCPQEDVSSSGQSTNFDKSRLRNRPVKPSIWISSQIYDQNFETQIVASDHTYYNSKLEPSGKNKNRSKISNKDQSNKPVKTSASSRVETHQSEVAQSFSGEKANTKTQRSQTQTILANADTSTPTDCSPDTLSKIRQEVGPPLPPLLAPLIATPPRTSQPLSPLISSSSPSSPASPVGQVSPFRETPVPPAMSPWPEDPRRASPPDPSPSPSAASASERVVPSPLQFCAATPKHALPVPGRLPPCASGHAAVGGPQENSVKILDTMYPELSARARTLNILKGNIQLTRGPPADCKNLPGPASAMIGFKTITSAATAFVKTGSSSGGDCNQDKSRDLGTQQDSSGKRTLSTSTLRSAKRLRLDTGSPEPETRGVTAEGIHKNLPGNLPPAEVATTNEERSCSSPAVSAVSQLPLSPKETVESHDKAIANALKKIAEFSFDLLPVIRSHVYVGNISKKPVMRDQEKEVVYEFSTTKKHLAECLLHSILSELKIQKISMDHNYIHALCRVYVGICRQLGDLERARLFCYSLLKEDFPESEKLTLFIANMWHDIFLSQSVINKAMQLVARQRAKGEVLNCLRAFLNWEKNAPVDVGFMVSKLLLTIQLCPKTEFQPSEKFGEDLSDNTWEYIFAIDLLCCHQKWIWTHDNIISKELWPVMDKWIKYRKGHANIAYTPDIIIASILRLIGRLGQLGLKEGFPSAVKNISSVIGMFIQHAHDEDIPWGIQLAAVYALCDLSPSNPAEISKILEAWRREASKSVPSAIVSCLEEVSALSTEELG
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.
Domain:
The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MYNPRCKDLDRDYFPSYHTTRFQDQPEPNLAVLEHFVRVTKQHGRELTEKQGITVDHLRYGEGRQLVDVFYSEKTTNQAPLFVFVHGGYWQEMDMSMSCSIVGPLVRRGYRVAVMDYNLCPQVTLEQLMTQFTHFLNWIFDYTEMTKVSSLTFAGHSAGAHLLAQILMRPNVITAQRSKMVWALIFLCGVYDLRELSNLESVNPKNILGLNERNIESVSPMLWEYTDVTVWNSTKIYVVAAEHDSTTFIEQSRHYADVLRKKGYKASFTLFKGYDHFDIIEETAIDDSDVSRFLRNIEIE
The following text describes a protein:
Function:
Required for proper formation of the apical ectodermal ridge and correct dorsal-ventral patterning in the limb.
Subcellular Localization:
Nucleus.
Sequence:
MEEQQPEPKSQRDSGLGAVAAAAPSGLSLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPLPQLLVASAAAGGGAAAGGGSRVERDRGQTGAGRDPVHSLGTRASGAASLLCAPDANCGPPDGSQPATAVSAGASKAGNPAAAAAAAAAAAAAAVAAAAAAASKPSDSGGGSGGNAGSPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE
The following text describes a protein:
Function:
Phosphatase required for histidine production. Also acts on L-galactose 1-phosphate (L-Gal 1-P), D-myoinositol 3-phosphate (D-Ins 3-P) and D-myoinositol 1-phosphate (D-Ins 1-P).
Miscellaneous:
MISCELLANEOUS: No redundancy with IMPL1 or VTC4.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLAQSHFFSKSFDLIPPQSPALRSANPSLRISSSYSNSRLSFLSSSAIAVPVSRRRFCLTMASNSKRPNISNESPSELSDTELDRFAAVGNALADASGEVIRKYFRKKFDIVDKDDMSPVTIADQMAEEAMVSIIFQNLPSHAIYGEEKGWRCKEESADYVWVLDPIDGTKSFITGKPVFGTLIALLYKGKPILGLIDQPILKERWIGMNGRRTKLNGEDISTRSCPKLSQAYLYTTSPHLFSEEAEKAYSRVRDKVKVPLYGCDCYAYALLASGFVDLVIESGLKPYDFLALVPVIEGAGGTITDWTGKRFLWEASSSAVATSFNVVAAGDSDIHQQALESLEWH
The following text describes a protein:
Function:
Secreted isochorismatase required for full virulence of V.dahliae. Suppresses salicylate-mediated innate immunity of the host by disrupting the plant salicylate metabolism pathway via hydrolysis of its isochorismate precursor.
Subcellular Localization:
Secreted. Host cytoplasm. Host nucleus. Note=Lacks a signal peptide and uses an unconventional secretion pathway for delivering effectors which plays an important role in host-pathogen interactions.
Sequence:
MSSFRSMLGVPPSTASTQDSVLVIIDAQGEYAEGKLKISNIEASRPNISSLLEKYRAANAPIVHVVHETPAGAPLFTQGTKLAEIFDELTPKEGEAVVTKHHPGSFADTNLQEILEKSGKKKIVLVGYMAHVCVSTTARQGAQRGWDVIVAEDAVGDRDIPGVDAAQLVKVALAEIADVFGTLVSSKDIN
The following text describes a protein:
Function:
May play a role in apoptosis regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGDAETKSNKLNRELLRWIQSLDLAYSIKNVKRDFANGFLVAEILSRYYDKDISMHSYDNGIGMKVKKDNWDQLAKLFSKFTDLEPLINKGDTDAIIHCQNGAAVTFLTKLYQCLTKRTIQPTAIAQPPPGAGSIGAPASVAKSLDRVEEIPPYAKPTNSAFIRDKMREPEIAETRDQTQLTRKVRDIHSQHEETQQCK
The following text describes a protein:
Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MAATQSVVLAVVLFLLVTESIATSKGWVSRRRGRRRSSEESEEEPTRPPCPPGPAGPAGPPGPRGPPGARGSPGLMGENGEQGNPGPKGHPGLPGPQGPMGEKGDPGPVGPIGQPGLPGLRGATGAMGMPGIQGPQGERGESGEAGQRGEKGHPGPVGPIGPPGKPGLQGEPGEKGVPGIQGPIGPPGNCTVGPTGPRGEKGDRGETGMIGPAGPVGPPGIQGPYGLPGIPGPKGDTGPAGSPGKIIIFLPYPSVGKSKNTSQSDDHAGSPDVPDDPAADSSAILTVIHSQTKDIPQCPCGLTEVYNGYSLVELTGSNFHPDHLGSARSCLPYFSVSPVTVCGGKVCTEQSTQKTLWLTSGEALPTSKHVTDDVMASAVSRCTVCQAHARVITIHSQRDQVPDCPTGYRSGWTGYSFKKKTADTGVNGPFLGDPDSCLRKYLDIPVIQCDGTTGTCSQPAGQGDSWHRASDSADTVVTTPAPAPASRCRVCVLDE
The following text describes a protein:
Function:
(Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRPLRHGQRLSPGSPLGLLLLLLFLFLRALGLGRAAPRLLDHPAPVCAQQGLNCTVKNSTCLDDSWIHPRNLTPSAPKLQTQLRFAQTPRGHLLPVVHIEWALQTDASILYLEGAELSVLQLSTNERLCVKFEFLSKLKHHHKRWRFAFSHFVVEPDQEYEVTVHHLPKPIPDGDPNHQSRNFLVPDCDDPRMKTTTPCVSSGSLWDPDITVETLEAHQLQLSFTPWNESTNYQILLSSFPHTENQSCFQYILDLPAASQEASQRCCNITIPLLPSSWCCRHHVQIQPFFSSCLNDCLRHSVAVPCPKAPHTPGGTCDLMPLWVYGFITGLAVLLVGSVILLIVCMTRHLPGSHCKKYENGTKCTDVLPATSPSPPPLKPKKVWIVYSADHPLYVDVVLKFAQFLLTVCGTEVALDLLEEQVISEVGVMTWVGRQKQEMVASDSKIIVLCSRGTRAKWQAILGWEDAAVQLRCDRGKPAGDLFTAAMNMILPDFKRPACFGTYIICYFSDISSEGDVPDLFNITSRYALMDKFEEVYFRIQDLEMFGPGRMHRVGALTAENYLQSPSGRQLCEAVQRFRRWQARRPDWFELENLRSAEDRDLWSLDEEAFEEPLPPLGGGIIRQEPLVREPASEDPLMVELLLSEEGGGPWKLDPQSQPWGQLLAAQTLQTSVVPMETVPPTQTVEPIPRAVGSGPGRLALVGAGEACPLLAGHGPWRNSVLFLPVHPEDAPAHSPTSSPTRPPEWSRGQLDGSLLPLLQQSTSCRAQDLLTPHGEKQRQSVQSDQGYISRASPQLPDPPGEAEGEEEQPLAPEGLESLRSLQLQLFFQELLKNPGLGLPEDLAD
The following text describes a protein:
Function:
Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate, which is the final step of de novo synthesis of GMP. The conversion of XMP to GMP involves the coordinated action of the glutamine amidotransferase (GATase) domain that catalyzes the hydrolysis of the amide side chain of glutamine producing ammonia and the ATP pyrophosphatase (ATPPase) domain that catalyzes the synthesis of adenyl-XMP intermediate from ATP. The ammonia produced by the GATase domain is tunnelled to the ATP-PPase domain where it attacks the adenyl-XMP intermediate generating GMP.
Miscellaneous:
MISCELLANEOUS: In absence of glutamine, can use exogenous ammonia to aminate adenyl-XMP intermediate to form GMP in vitro. However, this is likely not physiologically relevant as at cellular pH, ammonia is present as ammonium ion, which cannot serve as a nucleophile required for the reaction.
Domain:
The glutamine amidotransferase type-1 (GATase) domain hydrolyzes glutamine into glutamate and ammonia where ammonia is then use for the amination of adenyl-XMP intermediate. Upon binding of glutamine, the GATase domain undergoes a conformational change involving an 85 degree rotation, which is required for channeling ammonia from the GATase domain to the GMPS ATP-PPase domain; The GMPS ATP-PPase domain catalyzes the condensation of XMP with ATP to form the intermediate product XMP-AMP. ATP binds first, and its binding is required for the subsequent XMP binding.
Sequence:
MEGEEYDKILVLNFGSQYFHLIVKRLNNIKIFSETKDYGVELKDIKDMNIKGVILSGGPYSVTEAGSPHLKKEVFEYFLEKKIPIFGICYGMQEIAVQMNGEVKKSKTSEYGCTDVNILRNDNINNITYCRNFGDSSSAMDLYSNYKLMNETCCLFENIKSDITTVWMNHNDEVTKIPENFYLVSSSENCLICSIYNKEYNIYGVQYHPEVYESLDGELMFYNFAYNICKCKKQFDPIRYHELELKNIEKYKHDHYVIAAMSGGIDSTVAAAYTHKIFKERFFGIFIDNGLLRKNEAENVYTFLKSTFPDMNITKIDASENFLSNLQGVTDPEQKRKIIGKLFIEEFEKAVNNIDIDINKTFLLQGTLYPDIIESKCSKNLSDTIKTHHNVGGLPKNLKFKLFEPFKYLFKDDVKTLSRELNLPEEITNRHPFPGPGLAIRVIGEINKHKLNILREVDDIFINDLKQYGLYNQISQAFAVLLSSKSVGVRGDARSYDYVCVLRAVKTSSFMTANWYQIPYDILDKITTRILSEVKGVNRILYDVSSKPPATIEFE
The following text describes a protein:
Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
Subcellular Localization:
Nucleus.
Sequence:
MADISETEDSAAHHQDSKKTNVGSCLLKQAKKKGKTLSSAKCGPSSASAPAIIKSNGSVKPGGQVKLPMPKIDLKAFFDYYFVRKQHKKLKRRIRKRPPRKKTPEGQKPKIPVRQGQRRLRISVLERKKRAKERGLQFPFVEKLCGRKHIPLKLVCRYEQEAIQGYFRYIETLKYEQHLKKSLAKLNAGDDLENESLESRKYKYLDDDGPLSPIEEPIEEDQNINSGNDDIGARIVVSISLSLILHLTDVSLIFNTSINLKPLAAFLKCFVKGVSLL
The following text describes a protein:
Function:
Accessory protein regulating the assembly of the plastidial Clp protease system. CLPT1 first binds to the heptameric P-ring containing the CLP3-6 subunits followed by CLPT2, and only then does the P-ring combine with the R-ring composed of the clpP1 and CLPR1-4 subunits. Once the core complex is fully assembled, it then associates to the CLPC chaperone partner to form the functional protease. CLPT1 and CLPT2 are partially redundant.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The MYFF motif is functionally important for stabilization of the overall ClpPR complex.
Sequence:
MASYTVSFIPLTLSNPRIFVSRQNGSPSSSSRIPLTSSLLGKKLLATQPSHRCFVPKLRCLTSASTVLNVPIAQPENGSSDKIPKWSARAIKSLAMGELEARKLKYPSTGTEAILMGILVEGTSTVAKFLRGNGVTLFKVRDETLSLLGKSDMYFFSPEHPPLTEPAQKAIAWAIDEKNKSDVDGELTTAYLLLGVWSQKDSAGRQILEKLGFNEDKAKEVEKSMNEDVDLSFKKQGQ
The following text describes a protein:
Function:
Constitutive component of kinetochores that is essential for proper cell division during mitotic cell cycle (Probable). May play a role in the modulation of centromere during meiosis.
Subcellular Localization:
Chromosome, centromere, kinetochore. Note=Localizes at centromeric regions throughout the mitotic cell cycle. Co-localizes with CENH3 during the cell cycle, from interphase to anaphase. Localized at centromeres in meiotic cells.
Sequence:
MEGSKSEAVFDSMNLNPQIFINEAINSVEDYVDQAFDFYARDASKSLKIKGSDKQKSQALSNGIARVRGLLLSVIDNRLKLWESYSLRFCFAVPDGFVLPKSEESSSVHQDGLYDLELDAELDSLRDKLNVVGKRSVELDSELQALERSSVSRERSLRLVNEALELYDESSMDEIFKEMTKMASELRASVERLKTRRMKASESAKVKRLKNHGKEFSAMTFDGKLEDLEKFQAELRKM
The following text describes a protein:
Function:
Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate, glucose-6-phosphate, fructose-1-phosphate, acetyl-phosphate, glycerol-1-phosphate, glycerol-2-phosphate, 2-deoxy-glucose-6-phosphate, mannose-6-phosphate and fructose-6-phosphate. Appears to have a low level of phosphotransferase activity using monophosphates as the phosphate donor.
Sequence:
MSVKVIVTDMDGTFLNDAKTYNQPRFMAQYQELKKRGIKFVVASGNQYYQLISFFPELKDEISFVAENGALVYEHGKQLFHGELTRHESRIVIGELLKDKQLNFVACGLQSAYVSENAPEAFVALMAKHYHRLKPVKDYQEIDDVLFKFSLNLPDEQIPLVIDKLHVALDGIMKPVTSGFGFIDLIIPGLHKANGISRLLKRWDLSPQNVVAIGDSGNDAEMLKMARYSFAMGNAAENIKQIARYATDDNNHEGALNVIQAVLDNTSPFNS
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLTCMQEDLKRGLAAVGHAVAGKSTLPVLANILLATDEGRLKLTATNLEVGINRWISATITRDGAVAVPAKLLTDVVGGLPNDKVTLSLDQKTQTLRVECGRFVSNIKGVDADEFPSLPTVSAQTPLVSLPAEVWQEAIDQVAFAAATDESRPILTGVLVRTRDQQVTLVAADGFRLAMRTIQLSAPVAHAVDCLIPARTLSELARIIGDTDAEVAMVYTPGGSHVLFHTENIEVVSRLIEGRFPDFERIIPQQYLTRMVLDNSELAKAVKLASFFAGSSQNVVKLKIEPASELAPGRVVISANAAELGDNTSELDGSVTGEGGVIALNVRFLADAIAAVHSNQIAFEMQSAQSPAVFKPVGQDGYIHIVMPMSMR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MCVPAKQGTLHAKSPLPGLKIAGLLLRPRAANASSVDPRVIIYLERLLALKKVDASDVLSSAFQYSKDRLPKTGDDGSSKDSGWHNPPELEEVVFHRLSKAFQAEERPVNSTEGLRTLVVVTRWMQTMVTSHTSDTMIQAMAGIQQQPQQQSINVREGLGMLVVGVIENQKMLNILNKHHIKNCKSPGRSRKSNTTFTTNLATGEWRSERRSRTETQDLKSLRSNFEAVDWIFPTINTRAGLYIFLNSLIDSQNMATDLITAAFDILANAMYRSEPSQNMFCLKSFLINKIPILLLQISSSMFPMTAELSITQALSHVDPNAFPAFSQGFDDMLGNTNSLADVRQDFLNACALHGLITTATVERLLGETPMQGPPGTKYDKSTLLEQCKSNFDKISMYIDELDNLDGNAGAIVGAIAEFIPHLCETQMTMYLKQLSSLLFKKPQAIDVILQFTSPASILRPLCQILDDWHYDSDQGEYQPVYDEFGAVLVLVMTFMYRYDLTYHDIGIGAESFVARLMTKGNQSMLPDEMTDEQSKHLGHWLKGLYDAGNEGLSNDVFASCSPREFYFIVPTLFKQTVMALSAGILTFESVKGGLEYLMETFLLPSLIGGLIWMSSYALIQSHSDLDAIMRIFREVISSAPSSGDAQAMHSTILSIVSSRLEKCLRTIQRRDASRANSIEPLIQAIKGNLHSERSMFASMKELEQWTNAPNSTLHTSLRHTVQQLSQWASTSSIQPNPPSYTHRQVYVSLKIMGASKVIKAIVDELKAQTEASNGAAALDVGVSIICAPTVDDSPVPVAWLSSPIPASNPPRTRLNLREMLKHEFDNAAALVATDPLAAETVVRLHRRVEAQLSSIAENALQGHGSVLNLPNVNMGDMQSQSIPDDITKAIDDAAAASIADDITTMDNKALQRSMDDLTGPDGLDLSSIGMGTGDAGTGDMGAELGNLPDLDLGDMSGMGMDMDMDMAMGGGGDDDWGLDFDNM
The following text describes a protein:
Function:
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
Subcellular Localization:
Nucleus speckle. Note=Nuclear, in a punctate manner.
Domain:
The C-terminal domain is required for transcriptional activation.
Sequence:
MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPGGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endomembrane system. Membrane; Multi-pass membrane protein.
Sequence:
MDTTNITSRFLQDTSEHYDATTSFESMFRELESTSDAEIIMCPSVADRISDLWVILFWPIYVVLCGLATGYVAAKISHTPPVQTRSCLAACAFGNSTGLAMTLLTVIHDQFKKSSELGSIDASAFLSVYLLLYPVLQWGVGGWLLAPDESGGDNEEKDAVEKVEDGVSMRVRTNNRTQENGPIAIDCNSGSYQNQTTNGANEHDQLHLHPRIPSLHISHVLNHEPLQDFSPAMAAGQEEFGGVPPVRIIFGKGHRRMFTTGRIDSSNSGFATLMRELSFSSLNLEGTDCIPSRASFDEGSQYGGPLTMDSDAPANATGSQPAMHENVPLLARTKDGPSSAPKEELESIQKSDIVPLTETLMRVSRKVFQPPVIGALAGLLIASFPNIRGVLVNIWGDAGDAAPLQWMFDGIYAVGQAAVPINMTILGINLSSTFQKKKHSTDDEDDGNAKSKMLSNETMLAVVIGKMVVMPLIGIVSTWFLQRYYITLPDEIDATCYLVMMIVFITPTANNVIVMVELSGSSSKEGIARLIGWQYLASPIVLSFVLSAVVTLAQCHFDTTPVCT
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MAAWLGRRVCTFGVVGRAVRGQSTRIQTFGHRPAILTAQGRQFSAKSARYDNQHEPSHAVDFGDSTKAFVTKTTWEITRAVLVLQMCTSDMVVDNSLKLMEVGRRILGQTLFGYLMRATFYGQFVGGDTPDKMAATFSRLRDAGIHSMPLLTIEENVGDRAQIEERFYDNNTQYYVDTIRSTTDILAQHGAHARLFQMRLTSFMHAQLLVTLSQHLIEHPSSTELSVEHLSTGLCNDNKTFHLSFLSNEDNEHLRNALLRLHAVCQQAEACNVRMLVDAEYTSMRPAITRLVLAMMYKCNRTRPLVWNTYQCYLKSAYNSVVEDMKLARQLGFCFGIKIVRGAYMEHERAVARQQGYEDPIHCTYDDTGSMYHRVLDETLQFVKDSQGEQVDVIVATHNEDTIKHAIRRMQELGLQKNDRRICFGQQYGMADQISYHLAGAGYAVYKSVPVGPLHTTIAYLNRRAQENRTALRGFRQENRLLWAEMGRRARHPLSWWKH
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MTDAHTARTIVGIIGNVISFGLFCSPIPTMIKIWKMKSVSEFKPDPYLATVLNCMMWSFYGLPFVHPDSLLVVTINGTGLFMELVYVTIFFIFATSAIRRKITIAMVVEMIFMAVVIFCTLYFLHTTKQRSMLIGIMCIVFNVIMYASPLTVMRLVIKTKSVKYMPFFLSLASFMNGVVWVIYACLKFDPYILIPNGLGSLSGLVQLILYATYYKTTNWNDEDGDKEKRFTNAEIELGRA
The following text describes a protein:
Function:
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
Subcellular Localization:
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Sequence:
MILTKLKDFVGISEHDEYEEDYDEEMEFPQSVASQPPAEEVAPPPRISREPLSLNNETSIGTGVRNNVIGMPGINNSVAEVVVVEPHSFDEMPQVIQTLRERKSVVLNLNVMDPEEAQRAVDFVAGGTFAMDGHQERIGESIFLFTPNCVKVSSLAGRSQESNETSSSVSSDNFPTWGYETSRLAQ