lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MTEGLLPDNSLDDLKAGSLHDEQMGEESGDDAPTEISSKMTSDDFANGLKENESDDEEAKIIAKAKAEESVRRAASNKCDICGENEKKYRCPKCDSRSCSLACSKKHKADDNCDGVRGPWQPVSKISRFNEQRVNEDANFLKQMINGVTETLSGKSNQKEIKLDLKTEESDETALVTTTEGDQLSEENGLNVPPMPIPTIPDCLPEGLREQAASPLERFLIGACHKRRVFIYFNEEKEADDGSRHEQFSDTVFWAVTLEFRKEIKGEDGQGCGQFSSYQYTVQQVPESIHVRTVIKQFLRPRMHGPLVSKDELDMDRLQPFIDATAEKINIFMPAHMRAEEKFYTVNSETTFLDNLRQRVVINHPKLIICLQDELSSMGVISEEEQRMVVDARRAILDRRAGPCPRGSRGGPFRGNNFRGGSGGFQHHGGRGGGGGGFGGFGGFGGGGRGRGGGGGFRGGNKRPFEGGDRGGYGKRGRDGGRGGRGGGRPYNQRNRDLDDFDPFEPFAGPSGAAMLESWNTSVAKTEPDNSSSGGPKNYFPDLDALGSSPNKN
The following text describes a protein:
Function:
Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYSMTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYSEHSLLSTVQVINAVVSVGSQVVYSRLSDHFGRLRLFLVATIFYIMGTIIQSQATRLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLKWRMFYQYASYWPYIIIPWISGNIITAANPQKNWSWNIAMWAFIYPLSALPIIFLILYMKYKSSKTAEWRSLKEQARKERTGGLFENLVFLFWKLDIVGILLITVSLGCILVPLTLANETSQKWHNSKIIATLVSGGCLFFIFLYWEAKFAKSPLLPFKLLSDRGIWAPLGVTFFNFFTFFISCDYLYPVLLVSMKESSTSAARIVNLPDFVAATASPFYSLLVAKTRKLKLSVIGGCAAWMVCMGLFYKYRGGSGSHEGVIAASVIMGLSGLLCSNSVIVILQAMTTHSRMAVITGIQYTFSKLGAAIGASVSGAIWTQTMPNQLYKNLGNDTLAEIAYASPYTFISDYPWGSPERDAVVESYRYVQRIIMTVGLACTVPFFAFTMFMRDPELIDKATHEEFTEDGLVVLPDEENIFSQIKALFRHNRSNKKLGC
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASNNDWETVGSKKGSKNIKVTNKDQQQNASRKQRPNNNLDNMPRIEPNAPMKESPTIYQAFLEEELRKERKLLESEKENANKEAKKPSATTMKRRDRALSLKDCLTKLQIEEFESILKKDEILYPKNSNIWLRDIASFLNSQLDHITDFDPIIANKPNVLSIHSDYPVSEMPDTLKKYLIEKFSSFSSEANLSLLDYCIESLTTNAIKDQSSYGFRLIVQILLHSRPNLVLDHLTKFESLLQRNSNRPIKALAILWSVGQVGVTSLNNGVKVWFGVMFSLVNVRNLNSYVLQYLETLFTSHGFDLSDTTTTKSEKSPTTTTKLSSSSACYDCVSKTDYFKYLGELYSESSMLSKDLKTRLKCLYPAIKKLAWGDASKTLNSFFTGYLTRYTNDCADSKKKELLDCLIECLRLDAQSFAAWRKEYKKNISQSRLLLQYISEHESELKLKKRELSQTVDYFQIANDELMQKVPRTASQSTTSTTAAATTAAASSVSSANQKELEINVQLCNSLSQKHKKSSASRCTRLMMSLFVIICLSVIILLSFDVYHHGSTMESLTYKKLSEAGVINAIDYLYKNARDHLQVALKWISDNVPQHLERALELVTPYVQLLLKKIALAFDYAMDKTTNQRLWMVEMFHYAHNQLIIYTPGLFQCLEWVCEHAINMASLMFDNICRLVESIYKYLSNDVFVGQLSPQNVKNSLLELLKLAQNSIQSVIVWVQETAYKK
The following text describes a protein:
Function:
Involved in ammonium transport.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MHLRMASPPQPGPYMPDLPAVPAWLNKGDTAWQLVAATFVGIQSMPGLVVIYGSIVKKKWAVNSAFMALYAYASTLIVWVLVGFRMAFGDRLLPFWAKAGPALTQDFLVQRAVFPATAHYGSDGTLETPRTEPFYAEAALVLFEFEFAAITLVLLAGSLLGRMNIKAWMAFTPLWLLFSYTVGAFSLWGGGFLYQWGVIDYSGGYVIHLSSGVAGFTAAYWVGPRLKSDRERFSPNNILLMIAGGGLLWLGWAGFNGGAPYAPNVTATVAVLNTNVSAATSLLTWTCLDVIFFGKPSVIGAVQGMMTGLVCITPGAGLVHTWSAMLMGMFAGSVPWFTMMILHKKSTFLMKVDDTLAVFHTHAVAGILGGVLTGLLATPELCALDCPIPNMRGVFYGSGIGQLGKQLGGALFVTVWNLIVTSAILLCIGLFIPLRMSDDQLMIGDDAAHGEEAYALWGDGEKFDVTRPETTRTGGAGGAGREDTMEQRLTNMGARGVTIQL
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLSTKRKALDTGLQRRVRARRESSEEIEESSSDSAPSEIGRDDNEEEESSSDETEDEVEEEASESEEETSNDAAASISFGALAKAQATMSKPSKRDSKKSKKSNADGWEDNEATERKAGKKDQRDFTRSSKNAPTEISSKKAVSRRREVVPVKKREIRDPRFDPTHGPVDMGKIEKVYDFLVDYREDEIKKLRKTIKKTKDEDEKEKLKRDLLSMESRKKTDAKKRKAREILDKHRKEEKELVKEGKTPYYLKKAEQKKRVLLDTYGELKGRQLDRVIERRRKKVEGKEKKNMPRARRVVE
The following text describes a protein:
Function:
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Sequence:
MAIPKVPGKSGGAPQEFRVLEDHGRFLRGPGRITGARPGALRNGGNTTPRSAQGVRGLPRNKGEEGGSRKGSRERPSRVGPKRRPESQEPRGGAAGLPRWITGVRAQNKTQRPAEGGWAAPNGRPSPVRMRGSQARVRTPAWRRSLGRWALHASQPSPGRAAFHQGVRGALPRGTLRAMADSKLLVPELSEAEKMGADTARFEELLLQASKELQQAQTSRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADMTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVVTIAREGLEDKYSLQLNPEWRMLKNRPFLGSISQQNIRSQQRPRIQELGNLYTPDSLRPEEGPEKPHLNLWLEAPDLLLAEIDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLRINSEESKAAFHRKRKQLMVAMPLLSVPS
The following text describes a protein:
Function:
Plays a role in regulating membrane trafficking of cargo proteins during embryogenesis. Regulates snx-3 retromer-mediated endosomal sorting of mig-14, a transporter of Wnt egl-20 morphogen. Together with mon-2 and pad-1, may participate in the formation of endosomal carriers that direct mig-14 trafficking back to Golgi, away from lysosomal degradation. Required for Wnt egl-20 gradient formation along the anteroposterior body axis and migration of QL neuroblast descendants toward the posterior part. Maintains phosphatidylethanolamine (PE) asymmetry at the cell membrane and prevents the budding of ectosome vesicles that affect intercellular communication and morphogenesis.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage and alternative splicing; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGKRKKNDESSSSSSQKPCVSSSSDDFSVSFVRAEEDDVATTIRDKTASLKSNATHFSAASAAKGGMFDFRCCRSLFSRRRVLHSRTVRVGYGPVGHDANVTFTPNTVCNQKYNIFSFVPIVLFQQFKFFLNLYFLLMACSQFIPAIQIGAPITYWGPLGFVLTITLIREAFDDFVRYLRDRDLNSEKYEKLTRDGTRIEIRSADIEVGDVIIMHKDRRVPADVVLLRTTDKSGACFIRTDQLDGETDWKLRIPVPHTQHLPNEADIMELNCEVYAEKPQKDIHAFVGTLKITDDDNVQDGSLNVENVLWANTVVASGTAVGIVVYTGRETRSVMNTTLPESKVGLLDLEVNNLTKLLFCFVLVLSSVMVAMKGLDNLWYRYLMRFILLFSYIIPISLRVNLDMAKLFYSWQIGRDKHIPETVIRSSTIPEELGRISFLLSDKTGTLTKNEMHFKKIHLGTVAFSSDAFEEVGQHVRSAYAGRLAKHSFSAKLQNAVEAIALCHNVTPIFENGEISYQAASPDEVALVKWTETVGVRLASRDLHAMSLSVQLPNGQTLMKQFQILYVFPFTSETKRMGIIVKDETTDEVTLLMKGADTVMSGMVQYNDWLDEECSNMAREGLRTLVVARKPLSQAELEAFDRAYHAAKMSISDRSQNMANVVNRMLERDLQLLCLTGVEDRLQDQVTTSLELLRNAGIKIWMLTGDKLETAICIAKSSGLFSRSDNIHVFGNVHNRTDAHNELNNLRRKTDVALVMPGSALNVCLQYYEAEVAELVCACTAVVCCRCSPEQKAQIVQLLRKYRAPLRVAAIGDGGNDVSMIQAAHAGIGIDANEGKQASLAADFSITQFSHVCRLLLVHGRFCYKRSCALSQFVMHRGLIISTMQAIFSCVFYFASVSLYQGVLMVAYSTCYTMLPVFSLVVDRDVTATNALTYPELYKELGKGRSLSYKTFCIWVLISLYQGAVIMYGALLVFDADFIHVVSISFSALIVTELIMVAMTVHTWHWAMLLAQALSLGLYMISLILFDQYFDRQFVLSWVFISKTTAITAVSCLPLYIVKALRRKFSPPSYAKVN
The following text describes a protein:
Function:
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Subcellular Localization:
Nucleus.
Sequence:
MAGPEEAVHRGCDNHPPFVGGKSVLLFGQSQYTADEYQAIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVKVQLKDGSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPRQLPLDVDLTKTKREDFEPSVEQARYNSCRQNEALGLPKPQEVTSPCRSSPPHDSNIKLQGAKDISSSCSLAATLESDATHQRKLRKLRQKQLQQQFREQMETRRQSHAPAEEVAAKHAAVLPAPPKHSTPVTAASELLQEKVVFPDNLEENLEMWDLTPDLEDIIKPLCRAEPAQTSATRTFNNQDSVPHIHCHQKPQEKPGPGHLQTCNTNQHVLGSREDSEPHRKSQDLKKRKLDPS
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSWEDFLVEDPAKPAEFDFPLGKDSQSSSKPKKRFDDEEDEDEEENKESLQNDSHSVSQKSSSSSQNDQGSNKMTRIQQKIQERNFEKAIKASEAAAKEESLESSKEAMRQAEIDSDLANAMDLFDIVDKNSASANRSKQADQRQLKTKADYAAFQADILKKVKNCQTTAEYNNFVQDLIPLLLTGLNATNLKAVQKSVNKLVVNKEQQEKTQSKRGAAAPAAKPVSTAAPSKKGGKPTVNVNSKKTVADKSAYEDYIEDEYDDYADDFDDFM
The following text describes a protein:
Function:
Via its association with the multisubunit axonemal dynein complex, may be potentially involved in the regulation of cilia function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm. Note=Colocalizes with microtubules in interphase.
Sequence:
MPPKDGKSAKKKGGISKAEKERLQREEEEKRQREAEEARLIAEREENERLERERIEQEKQHILELKDRERREDELNELRHILDENHFAVTVWEAECREKSKWERYMLCDGSPDPSVQPEINTYISLWRDDSENQIQKVLEECALTLELEKELEFLLGDGPEPSIAEQYQETLLSLQNLIHYKLNQATEELLKFANYNSDIDTGNMQTVVKDSNITLCLWANLNKNPRFKGYKFEEVGLGFELPKPLAVIEVAVRILHTRYDHLSHHSEREQLQKRRSMMEAILTQNTESSAAVHNGKMEGERDESESSKQVDECHSVRSESRKRSAVSVISAKEGRKSSSIKLLEEGESQMEEITTTLEADQHDPYPSPAEPVTDTDVHIVDLQQFTPLGGVFYFDLFHMPPQSRTVKGWEMRELLDTGLQVFPYPTEQSRIQSSTSVKLDEHSNTTVASLPVGVTVALPHSVLFLEDPQVARWDPIGQHWRTDCISETSYDAELRTISFQMTAFYAFTLLQETYANMPFQSWELRPLGQDSALFTITGALIEVSITVKGKQCMLHTEETKDLDRLLGKWMSPSELQKAMRKAGINIFVNEYSDKYVSINLKDPLIEHAVYEQMALMSSAVAFSWSRWNAQCRQEHLVLQACEQLEVGPVAEKAWSLYLLGAQRNQHLKMKEQEDSFSPELAEGSEFHSTFLHMLRQDLSTEGQARVRQSHHLYIDTVQRLLCATRVLTYS
The following text describes a protein:
Function:
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADPAAPAPAAPAPAQAPAAAPEAAPTPDAAPAPAPAPAPAPDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVSIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPSKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIACECPEKLCAQGEGSMAKKVKRLLKKQVVRIMSCSPDTQCSRDHSMEDPGKKGGARAKSETGSASPEETPDGSASPVEMQDEGPEEAPEAGEQLPPFLLKEGGDDRLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDDVEVSVCSPHVFLQGCLQWVGYGAPGLITTHPVPQLIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGGPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPPTEQPMAPEEDKGVVISEEAATAAIQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIAEEEKMEAMPDTERKEDKPEGQSPVKAEWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPDGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVNRIESWLETHALLERAQTLPNGVPKDSGSPEPPAVTELSDFGREEPEDGGLAPGEASQGSDSEGGAQGLASASRDHTDQTSEAAPDTSVPPSVKPKKRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLMQFRAALMEAGMPESTEDK
The following text describes a protein:
Function:
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.
Subcellular Localization:
Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.
Sequence:
MAEQGAGGDGHRGGDGATHSDPASDGYKVQEKRTAPSRPTSTVSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPRQKSNRWSWGSPLHGSSSIHSGDPDRRSVSTMNLSKHVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVSRLLTPTHSFLARSKSTAALSGDTASCSPIIMPFKAAHSRNPVDRPKLFVTPPEGSARRRTIHGLASHKREREREHVPFHVSPGARRTLSPSNLKARSPAPARLWLPSKSMPHLPGTPRPASSLPPGSVRAASAQAPSSSPGNIRPFKREVKVEPEKKDPLPAVKSRVPLVKVEEVTVEEGTPVKPPEPAAPASAPIATPAPAPATDPAPVPAPSSTVTVGVVPKTSAGTTDPEEATRLLAEKRRLAREQREKEERERKEKEELERQKIEELARRVAEERSRREEEARRLEEEQAREKEELALRLAEEERERWEREEVERVQKQKEEEARAREEAERARQEREKHFQKEEQERLERKKRLEEIMRRTRRTETADKKTTEQRNGDIAKGVLTGEPEVPALPCMASSGNGESAESPHGVALQQSEVTTESSPDLEKQPNENGMSIQNENFEEVINLPVGSKASRLDVTNENPEIPLKPILAFNDEGTLGPLPQVDGVQTQQTAEVI
The following text describes a protein:
Function:
Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
Sequence:
MDSQSSILEENLEKILRGEGLEFDSVAEQVDPVTLRKNVCYIVGAVIFNSKEEVLMVQEAKRECYGRWYLPAGRMEECESILEALQREVREEAGIDCQPITLLLVQEQGPRWVRFIFLAEETGGSLKTTAEADDESLQAHWWDRKSPLPLRAHDILSLIDAGLKYRRNPWFPVTQPVDFPCHVVCQRLFLTFISSRADADDRLWLLMSNNNTSHHPRLPIVVSFRTYISKAVSKLIEDCMPSSYISVHIRGILGVQHNGRIPGKTDGICFNTLVLLENTEEGAEIGSPPSLETDCYRWQEVTNQGLKAKIIERIKDGSVLPFQSL
The following text describes a protein:
Function:
Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEVLKLCLLLTRKKQFEVELIPEKIGARRPWKLETSSTATEAVVSVVTYLEATSGNARDAKEAGIYIRVYGAGWMIPEFVRMLMLHYSKHGECILQEIGAAFRGEHATDLLLICDGKETVRAHKLVLAAASPLIRMILEETPVLDGVTTVYFPEVQVSYFRLLLDFLYSGQVYVRSVEEYHHLQDLLALLQIKASIWKNSDGSDAGEPRKSEPLVDINRNTEGITGSSVVHQHPSRRRRSKSQDSLSGDSASGGGGTGSQAGTPKKVSVKSERHSAGSSVDGDGDRDREENLEYLDEVEEAIIKSNNNHPLHPHQHHLVAGSGGHHLHHHHHHHHRQLHQISRHDGDDDAGGGSGNDGASEGGSGESGRAGSVAGESAGDRPTPTNLSSGGGGAGSGRRSGSGEPTEPAEDDEDYELDVEDRGGDGDEAAGEGETRSRRSDPSANRRRSSSDPVNLSIVKQQQDVDSDDANIDVETIGTATTKTLLPPRYLDPFRTKRKAAAYYIHPADAEALKPMDHEGLLHNSPDNYVVTPHRKRRPGFHNSPAQNPPFVPSYLDDLRARSKCFLSAPPTYLPEKYLSVLTRWNLKTHLRVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRNIINAPEAGGRYTCCFCSLVFETLQELVRHLSGHHNNLLLSKNLHE
The following text describes a protein:
Function:
Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW.
Miscellaneous:
MISCELLANEOUS: GadX and GadW are part of a complex system required for acid resistance via the regulation of gadA and gadBC. Many of the described circuits use mutants missing one of the network components. In the wild-type situation, however, many of the scenarios are not easily observed.
Sequence:
MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVFVSRDTLSLFLPMLKEEALNLHAHKKVSSLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSAQRLSNRDSAASIVAQGNFYGTDRSAEGIRL
The following text describes a protein:
Function:
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Incomplete sequence; MISCELLANEOUS: [Isoform 4]: Incomplete sequence; MISCELLANEOUS: [Isoform 5]: Incomplete sequence.
Subcellular Localization:
Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
Sequence:
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
The following text describes a protein:
Function:
Controls the length of the flagellar hook.
Domain:
Two-domain protein with the central portion of the sequence acting as a hinge or connector between the two.
Sequence:
MIRLAPLITADVDTTTLPGGKASDAAQDFLALLSEALAGETTTDKAAPQLLVATDKPTTKGEPLISDIVSDAQQANLLIPVDETPPVINDEQSTSTPLTTAQTMALAAVADKNTTKDEKADDLNEDVTASLSALFAMLPGFDNTPKVTDAPSTVLPTEKPTLFTKLTSEQLTTAQPDDAPGTPAQPLTPLVAEAQSKAEVISTPSPVTAAASPLITPHQTQPLPTVAAPVLSAPLGSHEWQQSLSQHISLFTRQGQQSAELRLHPQDLGEVQISLKVDDNQAQIQMVSPHQHVRAALEAALPVLRTQLAESGIQLGQSNISGESFSGQQQAASQQQQSQRTANHEPLAGEDDDTLPVPVSLQGRVTGNSGVDIFA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
Subcellular Localization:
Lysosome.
Sequence:
MDYAWLSVLLGTVLWPQGAQSLQNGLALTPPMGWLHWERFLCETNCERNPKNCISEQLFMDMADKMVSEGWLDAGYQYLCIDDCWLAPERDEKNRLQADPVRFPGGIKKLADYVHSRGLLLGIYEDVGSKTCEGFPGSQGYYDIDAQTFAEWGVDLLKFDGCYYGTLDKLEDGYRQMSMALNRTGRKIVLSCEWPLYERGIKKINYSEVAEYCNSWRNFGDITDSWGSVKAVMDLSSAVQEEIVPVAGPGSWNDPDMLVIGNFGLSWNQQVTQMALWSIMAAPLMMSNDLRDIPAESKALLQDKNVISINQDPLGAQGYRVFKADYFEVWERPLIKGSLAVAVTNRNEIGGPRNFLLSLSLLWEDRVCQNSCFITQLLPSFQKYGHLNDTSLLSLWINPSGTILLRID
The following text describes a protein:
Function:
DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.
Subcellular Localization:
Nucleus. Chromosome. Note=Localized to the sites of DNA damage.
Sequence:
MDFLSALENAENHIVSALPGDAVCLRPNSSRPQETPQAHSSKLSPSYPASNRSVLGLCFPTSRMPETIKEPPCKGAMFLRPVSISSSSSGSQQRMTGTKVSQESSGRQSSAAHSGFIFESCQHGIGDFETLDQDEFDKALASMEFEGAGLEPEVNRGASQILPAKHCEDPVLAKKARVADLSGSFQEGPIVHCRKPWPSLRPTTATGGLPVPATSDISTSHQRGSPVPAPQYSPVAGRTLQNGPQNYVPGQPLQSPRAWSSGKPRFSGPQCPHSSSAAFCRGPSPSRAPVSSVESPFSTPRSTSTTVTQPALQTPVVTNHLVQLVTATNRTPQQPSRPSIRAKTRRFPGPAGLLPHQHSGENLEEIMVSTPQTPTHGALAKFQTEIVTSSQGSVEEDFGRGPWLTMKSALGLDEGDPTCFLYTYSIVMVLRKAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMLGTVHRVLLETHQNELKPGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSLDSGDGDFLKPPQPLPKDLGNSHGSLQPDVAAEPTQGLRTAQNPPASPEEELPEADDLDGLLSELPEDFFCEPSGWSCLKTGHPP
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
Sequence:
MNYTYLLDEVSLSMVSIVGRKSAYLGELYKMGFNIPKGFIISSRGVNEAIKDLDDEIRGILSSVNLNDTTDLEKRSEMIKSMIIASKLPNEMEKEIYERFSQLGSKYVAVRATATSPLSGASFAGEYETDLFVTQENLIPSIKRVIASYFNPRAIAYRILTHNEAGMAILVQTMINPVSAGTAFSIHPITEEPDYVVIESSFGLGESVTKGMVTPDQYVVSKATRSLVSKRISEKVMKLTYDFAEKKIKSIELSKEEALAESLSDNDAIRIANMAIAIESIFKRNINIEWAIEDKKVYLLEVRGIRRLYPEF
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKLLLLAVVIHVLFLLSIFYIHFQSPILKGLPDGAEHDHPPADRLVLFVGDGLRAESFLRHDLNRTHFLRNTLLREGVFGISNTRVPTESRPGHAALLAGVYEDPSAVFRGWKENPVEFDSVLNRSSVSYCWGSPDIVHMFSRGATPGRVHVAAYDSNDESFAQSANTSLLDIWVFDRVREFLAGEQQTKGGVLSQKKVVLFLHLLGLDTAGHVHKPYSELFTENLITVDKGIESIVRLIERATKNDGRTAYIFTSDHGMTDQGSHGAGHPHETETPFLAWGAGFKHWKEAIPASDYSNALELDGKSIPVHHLNQADAAPLMAAVLGIAVPKNSLGKLPRSLLNVSEEYAAWAMRNNAEQLLSQYHHWQRESEGKMLQWLVSTKQTSLKVLIEALQSEIADADYRKDYTEVQSLTKMLIDTALNAIEYFQTYYKPHLYIALTLTMLGWLLLLAKETCTPTNTRIFALNRAVALTAVVVALTVTIFNIAQNTPTVVVLYFVLPVILWGYIGAHWRQYAPLLQGKAAMYSAGFIIAAEALVWAFMDRRLLAPLLWVHCLIVVKPLLDRKPSDANNRSMVRHWIAFNLLLSGFFLLPTIGRDSSNLYLLCISIFAWTAVNTMIVHRSKHTSLLKSIAVLVQLLQAANLLYLIFLIQASANVPQWCRSLCWVFSGLGLLAPYSTSTSVSDRMLALFSGLSGPYMMLSLSYEPLFLLCFCYTLYLWLNVENCMRNKRIALDSFHYCSSIQAEGSIDFKNTRLTFGFMLFLLVSFFGTGNLATVSSFDPNWVRCFVTTFSPFTMMALIVFKLLVPVLLLICVLKAMVIISSVPKTKMFTLTLMVCDWMCMNFFFLVKNKGSWMEIGSSISHFVILECTTIVVIMMYELARFVTDVTLTTSTPRTRPAQAYVISSQCLPYTNKERVE
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MGSTKPRPSGKNSISHAQSLPGKTFIIDNGAYNMKAGYAPDSQPLDDEEIALSACAAIPNAIVKTRANRTYVGAQIGTNVTDWNEMLFRRPVEKGYTVNWEAQKEIWENSFFDERTVRSKELHIADPEDVTIIFTEAPNALPALQKNADEIIMEEWGFGGYLRCVVGMAKPFALNTGPSLNAWNEIQSLFEDSVLSQPRAVASPAECLLVVDSGYSHTVITPVYRGRPLQRGIRRLDLGGKHLTNYLKELVSMRQYNMVDETYIMNEVKESVCFVSNDFNRDLERTWKGNRKRGQPDPTDGVVVDYVLPDPNGGKRGFMRPHDPLLGSKKRKAVLAGASAEQLNEDVLVLGNERFTVPEILFTPSDIGMKSAGIPDIILQSLSVLPTGLHPAFLANVLVVGGNSLLPGFMERLETELRQIASAECVVRVRRPKDPIRFAWLGGSRLATNKEELKKVAITRQEYQEHGSSWTTRKFSGAL
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MAASLFLTLVLLAATAAQAVPVPEAWLDAESFLTIFAFKGPVRWSNCGDPATQSFNGTISPNPPIRGGKIKGSIAFVPDADFTSGKLSVDLWYNGSPAIQVPFPIKCNPSTKGYCPMKKGVKVSAARAVTVPKYLRPGHYNGTAILLNQDNHQMLCIKAEGDLA
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MISYAEALAIVQQQVAPLAGEWVSSTEAEGRILAQHVSSPDALPPFDNSAMDGVALATAGNGARAGSDYVIAGTVAAGEVPATADGAAWEIMTGAALPAGADAVVPIEQLEILAQHADRPSLIRLRADVRAGQHIRRRGEDVAVHDRVIEAGTLLRGAHAMVLAALGCARVPVMRQPCVALIATGRELVADPEQRLLPGQIRDGTSHYLLSQLRAAGARVVWQAQVGDDPVAFDAALAQARQAGADVILSTGAVSRGRYDFVPDALARHNAQCLFHKVAVRPGKPVLLARLPDGVLYVGLPGNPMASAAGLRFFVEPALRGLLGMPHEHGLPVSLHAPLPARPVWRQHLRAQLTCSATGMLSVQVLPQQESFRVAPLLQANVWAVVEPQPDGAAPSTVAQVYGLGHLQPAAPVLVP
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MIWNFFKQIVHIEQIYLDHAGSTIYSQLHLKSYFDDLSHNLYGNPHSKNKSSLETDSMVDEVRKKVLNHLNTSENEYSIIFTLNATKALNLVAKCFAFKSKAHSVNKGLFVYLNDNHTSVVGMRNSVNVKTNADIVCIREHDLEEFVKKRISLKPFEKFESTFVNNLLVYPAQSNFNGRRYPMTWIDDVQNCSGFLGSSADWSVLIDSASYLSTSTIDLSIHKPQFLVLSFYKMFGFPTGLGCLLVNNKKIFLLEKEYFGGGTIDMMLPFKDVQSFRPGMSDKFEDGTLPFLEILAVKHGFDSMLQIYGSFENISNKTFELSRHVYSRMKLMKYNNGQNLVRLYHDENSYSFSTKILQGPIINFNLFKPNGFYIGYTRVEELARVNNIHLRTGCFCNLGACQIYLNLTDEDFMQNFNLGHVCGDGIDIINDRPTGSVRISFGFSSTAADADYFCNFLVTNFLEPGNESLQEFSNFFYLTKFEYVLKEIWIYPIKSCSGIKLGKCNLDTRGLKFDHHWMVINESDGKCINQKINSQLCMIKVKISDISKFILSSEDMELSIDDEPKKNESQIKICEGKICNDRITVNVSNDEINGWFSNVLHIPHAKLVVQSTDDKRTVKQKSDASEKEAFLNLSNEGQYLLIGSASLAYLQKKITDNSVNGKPEFTDLDTLAARFRANFIIETNVPFEEDGWSEIQIGMARFKVIKLCNRCKAISRDQNTGIQHKEPLQSLMKIPNRNVSN