lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a continuous role in plant development probably in the structural organization of compartments.
Sequence:
MFGRTPKKSDNTRYYEILGVSKDASQDDLKKAYRKAAIKNHPDKGGDPEKCCYDGVSSCAGCQGSGFKVQIWQLGPGMIQQMQHLCNECKGSGETISDKDRCPQCKGDKVVPEKKVLEVVVEKGMQNGQKITFPGEADEAPDTATGDIIFVLQQKEHPKFKRKGDDLFHKHTLTLTESLCGFQFVLAHLDNRQLLIKSNPGEVVKPGSFKTINDEGMPMYQWPFMKGKLYIHFSVEFPDSLSPEQCKALEVVLPPKPVSQYTDMELDECEETMPYDVNIKEEMRRRQQQHQEAYDEDDDVPSGGQRVQCAQQ
The following text describes a protein:
Function:
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MDRPRRIRFLPLLLPLLALLHLHAGQETSIESCCTHGYEWASQKRDCSSLPLNPDSKECSIAQEQCCLNQLEELHCTAGIDIASKQEDCDSHNSNITCEDKITKKCCYCCFMGKVAQKQRNSCEQSLLMGYQCGLVFRACCVEGQESADTLIVDGTNKELDLASPVEVDHEDHYLNDRCRGGGPCTQQCRDTGTSVLCSCFMGYQLQPDGFTCEDINECITTSNTCAIGQICINTPGSFRCQRETSCGTGYELTENNLCKDIDECETGTHNCLPDFICQNTPGSFRCRPKQQCKSGFIQDALGNCIDINECLTANAPCPVGQTCINTDGSYACHRNVPNCGRGYHLNEEGTRCVDVDECLAPNLPCGEGHICTNTPGSYRCECRTGYYFDGITRTCADVNECRRYPGRLCAHKCENTAGSYYCSCTMGFKLSSDGRTCEDINECESNPCSQECANVYGSYQCYCRRGYQLSDIDGITCEDIDECALPTGGHICAYRCINVPGSFQCTCPSSGYKLAPNARNCQDIDECVAETHTCSYNETCFNIQGGFRCLSLECPENYRKSGETVRQEKTDTVRCIKSCRPNDVNCVLDPVHTISHTVISLPTFREFTRPEEIIFLRAITPAYPANQADIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVKPIIGPFYATLKLEMNYVVGGVVSHRNIVNVHIFVSEYWF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (By similarity). Plays a key role in RPA-mediated DNA damage signaling and repair (By similarity). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA). Mediates ubiquitination of the hmces DNA-protein cross-link, possibly promoting its degradation.
Subcellular Localization:
Nucleus. Nucleus, PML body. Cytoplasm. Note=In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies. In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair.
Sequence:
MAQEEMEVDLPNLLGPMDSNRVSTSHQPLGSRQVLFLPPPITYSDDSEELFLGPTEPHDVIVLDSGEEAPAQVVAPTNPLQMLHGALEQLRQAAELRSSVRRTRVQRRSTRRQQRGGSQRTAGTSSRAALSSFFQINRTQGLAPTLEREERNTVLRTESLRTLPGDSSDETVELSEEEEGEGSSTDVDEVEINAGAAPPAEPAPEELQINVVEVQAEASAVSDSLPIPERVTLPLQIQTKQKTPVKLLSPVKPLPPEEDEGDTCAICFEPWTNAGQHRLSALRCGHLFGFTCIERWLKGGASKCPQCNKKAKRADIVVLYARSLKALDTSEQERMKSSLEMEQSMRRKAQLESAQCRLQVQVLTDECGKLRNQIQELKMLIAQHGTGTSVQASSSRSTISGSLSSSQGQHKYSFEKAILISQTGSCRVMSYCESMSCLVVSQPSPQTTLIPGCGIKKLSAANLKSSQYVPIHSKQIRGLAFSNRSEGLLLSAALDNTVKLTSLLTNTVVQTYNTGRPVWSCCWCSDNSNYVYAGLINGSVLVYDLRDTSNCVQELVPLGSRCPVVSLSYVPRAASEVFPCGGVLVGTLEGACFWEMKDDQYRPHVLPLEPGGCTDIQIESNTRHCLVTYRPGKNYNFVRGVMMELTSNRLNDSEDEYSCSCYPVQTFNAGSTCKLLTKNAIFQSPERDGTVLVCAGDEASNSAMLWHSGNGTLLQKLQADQPVLDICPMEVNQSSMLATLTEKMVKIYKWE
The following text describes a protein:
Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNLQPITDLLKALNSGNTTTIQQAEQLYADYKNHQPDQLVNSFIVLIRTSQDELLRSYPPVLLRTLVNGNDSGNILKGLKPETLVTLKTELMFAVREEPKNHIRHSILNVIAILAIQLVPEQKWPEILSFIIESSSSPEENLRESSFYLIGAIIDDSRVAETLAPHFDKFALLVEKGLNDPSAKVQVSALETVSTFIDANPEKAEVFKPLIPAMLNTIQKTIESNLEKEAQKGILTFIIIAQYHSDWFKTNFDMIFKVFFQFLEHQSLEDETKHACLHFFLTFAEFKSSIMKKKLYLEPIVLLLLKWMSSVEDMDLKDWNSLDTEPSDDDDSNVAFEAIEALSHCVSKGLWEFFLQCAPTLLNSGNWKERYTGLMTLSSISEGCEKQIKTNFKLIIQSILPLANDSHPRVRFAFFYCLGSFASYLKREMQDLYKTLIPVSLEHLNDPFPRVTISNCEFLTLFLDEIKPNRVKEFKDQFLGRLSPLLQNENYKIVQHSLNAFSSVVDGIGEEFTQHYSEIMPFLIKILRTQTSVETKTLRGRAIETISLVGLAVGKKVFLNDCIQIIQYVSSLEKFKDDDPQVDFFLRAFTRFAQCLGEDFIPYLKYSMSPLMDAINGKVDSSVENGEDFSDESNNSGSIVMENKAMALEMVSIYAMELKHHLFPYVEQLYKGSIELVDFPFSSLVAIQAVNLIPFLVKISKQHFEAVGGLKDGMKAEFTSRLFLDSYERMAASIKTESEPDTLSAKLKALSDLMDIGGQCEQADRILSLTFEVANESFGTLQELETEYQENIDEEDEDADESPEREIIDDAYNSLAMVLGEVCIQFKEKAVPYIATVLPAMIELIETAPSVEIKTSMICILDDLIENGGQKAFELYPHIIKPMMNCTLPNLDPSLIQSAVFGIGLAAENGKDYFTPFLMESLQLINNVIVSVNSVQEQDDDLIAARDNAISAMGRIITNLPQHLGNNFPQTIALWLSYLPIQDDGEAGSIIKSLCTLIRDFSQQIMTQQYIVKVLEIIAVGLHKKAVNPDDKQIISLALRSQESLVAQSLFQLSAENQAILANFFKN
The following text describes a protein:
Function:
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.
Miscellaneous:
MISCELLANEOUS: Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.
Subcellular Localization:
Secreted.
Sequence:
MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPTLL
The following text describes a protein:
Function:
Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (By similarity). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Photoreceptor inner segment. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=In photoreceptor cells localized to the joint between the inner and outer segments, specifically localized at the mother centriole (basal body) and the adjacent centriole as well as between the two centrioles but not in the connecting cilium.
Sequence:
MKNVEFSLERGQRLKMPARKLREIVSPNQGNKLAVVEDELPRVPPALAANKRLAVETRTSSNGTLCGSLDLTSARLYHQPLLESPPASKKSDFSKDAVVRQLPLNKTEENNAPKANDIFISQYTMGQKDALRTVLKQKAQSMPVFKAVKVHLFEDTSTEKNTVAQETETPPNRIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNCVGELLTKLQETDKQLQRVTEHQASVQSKQEKVHCHDHDKQMNAFMEQHIRHLEKLQQQQIDIQTHFIDAALKASSLQLGMSTSRAVGKYSGKLGSPSVGSSVFSHNTFVSKRVPLSEDTDFDGQKSPLETPAPRRFAPVPVSRDGKITKRESPTEEKENMEMNSPKGNVRLLEQVLNSNECLTRKTESSDITSLTQPKMGWNLEKRDSTETLHSQIFPSSEERGTAQVPVPKYNDVVHDLGQKKQASDMLQIKQSPVTLRLSDHPHNPALLQTTNTRSVLKDAAKILRGVQNNKKVLEENLEAIVRAKDGAAMYSFINALATNREMSEKIRIRKQVDEWIKIISAEIQDELMRKDYEQKRFDPKNQRNKKALTMSRDIKANNQEKTVNRSVIPRSHYQKQTQEQFTSPPVRNLPASGPQKERSGLLKSATTLQDEDYMLQIYGKPVYQGHRSTLKKGPYLRFSSPSPKAKPQRPRVIELVKGTKVKSAKTQTDFHAASRMKMDSKIQHPITALPHADQQYMVSPSREMPTVSGTLEGHLIPMAILLGQTQSNSDSMPPAGVTVNKPRPVTVTTSIPPASRKGNAGVKKPNVAIVEMKSEKKDPPQLSVQILPSVDIDSVSYSSTDGASSPPSPKEASLPPLHTWIQTPDFMKVDEEEVPLPGTNFDEVIDVIQEEEKRDEIPECSAPMLEFNRSVKVVPTKYNGPSFPPVVSAYHPTTDILDKVIERKETLENSLIQWVEQEIMSRIISGLFPLQQQARLDASVSVSEASEPSASDIVAGTSSGALQRMVDARVPVNSDMVSHFVNEALTETIAVMLADREAERQRAAATSVPGDLSGTETNLLARVCAPVATPQPTPPCSPSPVREHVRVKTPDSSPCESDPDAASSIKEIRVEKGSDMPAVMLVSTPTRTPVATPPPAAALTPTLSETSIDKLKLSSPELPKPWDSGDLPLDEENPNSLQELPHPRAVVMSVANEEPESVDFSAQPAPPEPAPSAPLPEGTKAPSLQRVPSSGSSTLENTLSTVTETETLDRHISEGEILFSCGQNLATKRPGDLFLMNINDSLSSTLQDALEMEDDPPSEGQVIRRPHKKRHEDAIVALLTKQQRELLVSQQEEDLDNSVGELSEGQRLVLKAAEDISAGPSGQMLPPTSPAEPSYQHADPRLVLQQSDMASGNICEDLCASHGPMSLRELELQPDSNLILPITHTTTAVSDGNLPEAAEDFSQYQQKQDSDIKQVEHKPIQRHLTSVRNKPDSTLSQHQGGPADLLLIAHVSPARMSVTLPSANLEDCSQSLSTSSMHGGTESSGTDTF
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
METHDVSQARHQNAYWVEGADINSQFTSPNFEQSGVMNNEGAPEFVDQSMYYPAATNYGYYCTGFESPGEWEDQYRIFGVDGPDVQYMGGQDESFPLVYYNNYGYAQSPYNPYNPYIPGAAVGVDGSYGGGQSYYTLPNHQNPASPAYDPLVQLDNFPDSSANSVFGASASVSRSDGRGLKQKFNEASGNFSRNSLILSTNQTSSVAMVSEGPRANNGRKQDLTHANVSGSRSLNAASSAVHQDRRTDASVQPVDTISNGNVISHHNQLIVASSRSGFSDFAANANGQSSVAKLRPKALGLGSSDGNVSADVLGDQNRGPRTSRSKHQLSVKAYTTKVGGGNEQDSIIIYTDQYNKEDFPLDYDNAKFFVIKSYSEDDVHKSIKYNVWSSTVHGNRKLGNAYEDTKKVSAEKSGVCPIFLFFSVNASGQFCGVAEMIGSVDFNKDMDFWQQDKWSGSFPVKWHIIKDVPNPNFRHIILDNNENKPVTNSRDTQEIMYSKGLEMLKIFKNHTLKTSLLDDFMYYENRQKIMHDQKAKLLIRSFKSPVFIPSLAPRKLNIVPDKPPSKYEKNARLKDDSNSLNQMSISNSEQNIHISDVPNIKSVNEQAEKIAVEEDISSILKIGSIAITPKQVATKQSGIGSREQIDILTVGSVPVKVNGLAGSSGFLKVGSIQLDPKALQPQKGDAAAKSSFQK
The following text describes a protein:
Function:
Transcriptional regulator (By similarity). Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication.
Sequence:
MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKSAVALRLTARPILDIALQYRFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPLRLGEFTMPEHKFVTLEDTPLIGVTQSYSCSLEQISDFRHEMRYQFWHDFLGNAPTIPPVLYGLNETRPSQDKDDEQEVFYTTALAQDQADGYVLTGHPVMLQGGEYVMFTYEGLGTGVQEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCELLIPIRR
The following text describes a protein:
Function:
F-box protein probably involved in ubiquitin conjugation pathway. Involved in the resistance to ciclopirox olamine (CPO), a synthetic antifungal agent.
Sequence:
MSSASRLQNVNIVSNNYSRYGTSVYDKLYHSNGSGSNNAGKNSTTVGKLSSISQKSRSKQRHGSNCSRSMSQSPLSTFKSPLSNQNQSSAPDDLASIGQRRSDDVTSLDNETIITMNSRKSRIKKKYKSLISTSSKKFMNKLYDHGASSDSFSIFSLKTSHSGKHENSRFEKLRKRKYHAWGKFADINDLPVEIIAKILSEFELGRDQKTLVRCLYVSKKFYKATKIVLYRLPYFTSTYRVAQFVTSLRLHPDNGAYVKVLDLSHLKPGIIGQDSKDSQGLDDDGHSRRHRRRRRRSTNTSLNLPPATPTSTISNEDDANSGLIKDDASNGSEVEDLALAGWRDWRYRNEPLYSSPLLNSFKLKKVVSRSSSITSTSSGNSTGVHSTRRQRSNSSVASITTSIMSSIYNTSHVSLSSTTSNTSNGNISSGSNLSRVSTAGSLKKASAKSTRSSPQKAKPISDITSSSWFRMRLSSRNRKARTANTINLKNSKDKSDDDFKVLKHDSGHPSNYRSSTLKFSIEQPFSTHHPYANKFLLKYAPYKDLPLGYILHMLNLCPNLVELNLSNLVICTDFKLINQRSERRRMTSSLLPAVQESSVSAGPEKDLEIVYMTDSGKGYEYYEGLSKKHSRSSSLGTNPSSWIGGQANWTDYPPPIDAQTKTREEHRRNNTLNNKNVVLKKLNPFEIFEMICNRNEEKGGYCSLTKVKMNDIVWCRQYMVKYFVMRTFRQHLDYKSMENNSYERHLFSFRDSGLDRNFSWACNAKLHEFVALMVMDHLSNLDDLGLEELFNIKSEKLYIKNYCCRDPDILEISNLFDIRYGAGSEADATSDSNLEAESLQFRLTILKTEKPTSFWLTKVSKDYVSLVVKLCVDDDIDMDKMKVGKPTLRIDSITHNLISRLKELRRVDLRRNVGENNYYAESII
The following text describes a protein:
Function:
Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of ochratoxin A (OTA), a mycotoxin composed of a chlorinated type I polyketide dihydroisocoumarin moiety linked to L-phenylalanine, and demonstrated to have nephrotoxic, immunotoxic, genotoxic, neurotoxic, and teratogenic properties. OtaD chlorinates ochratoxin B (OTB) at the C-5 position to form OTA (By similarity). The pathway begins with the highly reducing polyketide synthase otaA that catalyzes the formation of the isocoumarin group during the initial stages of biosynthesis, starting from one acetate and 4 malonate units, to originate the characteristic pentaketide skeleton 7-methylmellein (7-MM) of the OTA molecule. The newly identified cyclase otaY might be involved in the polyketide cyclization reaction during the initial steps of the OTA biosynthesis. 7-MM is then oxidized into 7-carboxymellein (also called ochratoxin beta) by the cytochrome P450 monooxygenase otaC. The NRPS encoded by the otaB gene is involved in the linking of phenylalanine to the dihydroisocoumarin ring. The reaction catalyzed by NRPS results in the production of ochratoxin B (OTB), which is the non-chlorinated analog of OTA and which subsequently serves as the substrate of the halogenase otaD for chlorination activity to form the final molecular structure of OTA, containing a chlorine atom in the C-5 position of the molecule (Probable).
Sequence:
MEIPHKATVLVIGGGPGGSYTASALAREGIDIVLLEADVFPRFIDLDETFVNYGFVRKNASHGSLADTDFILQPGADTFAWNVVRSECDDLMFKHASNSGARAFDGVKVTAIEFDPLDESAIDDHPGRPVSASWKAKDGRTGSISFDYLVDASGRAGIASTKYLKSRTYNSYLKNVASWGYWRGATPYGVGTSVEGQPYFEALQDGSGWVWFIPLHNGTTSVGVVMNQELATQKKKSSTVTSSRAFYLESVEGARVISQLLQPANLDGEIKQASDWSYNASSYGSPYLRIVGDAGAFIDPYFSSGVHLAVSGGLSAAVSIAASIRGDCPEHTAWQWHSQGVANRYGRFLLVVLGATKQIRARDSPVLNSEGQDGFDDAFAVIRPVIQGTADVQGKVSAREVLDAVTFSTNAVRPSAGGQNVVLEESSRSLRSQVEQEMGDVANSLAKAYKDTDVYEGLMARLERGSLGLKAVGVMG
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for normal endocytic and biosynthetic traffic to the yeast vacuole.
Subcellular Localization:
Cytoplasm. Endosome. Late endosome membrane; Peripheral membrane protein.
Sequence:
MKVKATKLRIKQRRKNKGLNISRLDIIRAEMDVVPSPGLPEKVNEKSKNIPLPEGINLLSSKEIIDLIQTHRHQLELYVTKFNPLTDFAGKIHAFRDQFKQLEENFEDLHEQKDKVQALLENCRILESKYVASWQDYHSEFSKKYGDIALKKKLEQNTKKLDEESSQLETTTRSIDSADDLDQFIKNYLDIRTQYHLRREKLATWDKQGNLKY
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.
Sequence:
MTGPEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLRDGDVVVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDRTLITENRLGLVQAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLGVTVAVVITDTMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAAAADLVKGKLTATPVAVVRGFGVSDDGSTARQLLRPGANDLFWLGTAEALELGRQQAQLLRRSVRRFSTDPVPGDLVEAAVAEALTAPAPHHTRPTRFVWLQTPAIRARLLDRMKDKWRSDLTSDGLPADAIERRVARGQILYDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVRGLGSCWIGSTIFAADLVRDELDLPVDWEPLGAIAIGYADEPSGLRDPVPAADLLILK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGPLLKKEMEVSCKMTKKTMHDLESHNFPVYKQTEEGYPSCLKKIGYCSTHPLSKEKCKQSNGTLHGLEPAKERFLKTSQAFASKELTLLPSSDSKLDQKAPEDYCEDGFVALGAPVEISENRHVDIEPLLMRSESKTSNSKRDSCNESTVMLEDAITISGAGSLSQKHERQPSLLETLNEHELSLSNLSVNDPFSLANVSRNSSLLHLFNYFPQKAPTVSSRKKLLILDINGILADIVYPPPKGYKADTKIAGRAVFTRPFCSDFLKFCLERFNVAIWSSRSRKIIDRLVNYLMGDMKDQLTFCWDLSYCTGSNFRTLENKHKALVFKELRKVWESYDDPDLPWKKGEFDESNTLLLDDTPYKALLNPPHTAIFPYSYDYKYRADDAIGPGGNIREYLEELAMVDNVQEYIEQHPFGQSAITERSLSWQFYDKVIKGQSAVTAGG
The following text describes a protein:
Function:
Transcription activator essential for the anti-viral defense called virus basal resistance response pathway. Not involved in HRT-mediated hypersensitive response (HR) and resistance to TCV. Binds DNA non specifically. Activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity); (Microbial infection) Compromised function in defense response pathway when interacting with the invading viral capsid protein (CP) of turnip crinkle virus (TCV) due to abnormal subcellular localization.
Subcellular Localization:
Nucleus. Endomembrane system; Single-pass membrane protein. Note=(Microbial infection) Nuclear localization is blocked by its interaction with the coat protein (CP) of turnip crinkle virus (TCV), thus leading to its accumulation in inclusion-like structures peripheral to the nuclei.
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MKEDMEVLSLASLPVGFRFSPTDEELVRYYLRLKINGHDNDVRVIREIDICKWEPWDLPDFSVVKTTDSEWLFFCPLDRKYPSGSRMNRATVAGYWKATGKDRKIKSGKTKIIGVKRTLVFYTGRAPKGTRTCWIMHEYRATEKDLDGTKSGQNPFVVCKLFKKQDIVNGAAEPEESKSCEVEPAVSSPTVVDEVEMSEVSPVFPKTEETNPCDVAESSLVIPSECRSGYSVPEVTTTGLDDIDWLSFMEFDSPKLFSPLHSQVQSELGSSFNGLQSESSELFKNHNEDYIQTQYGTNDADEYMSKFLDSFLDIPYEPEQIPYEPQNLSSCNKINDESKRGIKIRARRAQAPGCAEQFVMQGDASRRLRLQVNLNSHKSETDSTQLQFIKKEVKDTTTETMTKGCGNFTRSKSRTSFIFKKIAAMGCSYRGLFRVGVVAVVCVMSVCSLVA
The following text describes a protein:
Function:
Plays a role in the accumulation of vital dyes and endogenous fluorescent compounds in lysosome related organelles. Has an effect on lysosome related organelle (LRO) function, in a pathway with serotonin.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cytoplasmic granule.
Sequence:
MSEEEGRERAVTVEGDAESMNDGRALVQPPARSGDVITPTRAVLTLSKSMFNAGCFSLPYAWKLGGLWVSFVMSFVIAGLNWYGNHILVRASQHLAKKSDRSALDYGHFAKKVCDYSDIRFLRNNSKAVMYFVNVTILFYQLGMCSVAILFISDNLVNLVGDHLGGTRHQQMILMATVSLFFILLTNMFTEMRIVSFFALVSSVFFVIGAAVIMQYTVQQPNQWDKLPAATNFTGTITMIGMSMYAFEGQTMILPIENKLDNPAAFLAPFGVLSTTMIICTAFMTALGFFGYTGFGDSIAPTITTNVPKEGLYSTVNVFLMLQSLLGNSIAMYVVYDMFFNGFRRKFGARFPNVPKWLSDKGFRVFWVLVTYLMAVLIPKLEIMIPLVGVTSGALCALIFPPFFEMITFWTDWKGLLTYRQRMTKIFINLVVMAIGVFAIIAGVYTNIHAIIQSFSQPDP
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MWFKLTLLLVAAIAWGGSAEQARFDNYRVYEVSIETERQLKTLQHLELNPDGYSFWESPVQTNMRLSIVVPPHKFAHFEELTVALALKTRLQIEDFQKVIDNERPMRSTRATFGWTDYYTVDEIYAWMDQMVAQNPTILSGSVYGKSFEGRDLKAIKLSHKAGNPGIFIEANIHAREWISSATATWLLNELVTSSNAAVQNLAQNYDWYFIMVANPDGLTYSKTTNRQWRKTRQPVNALCVGADPNRNFDYMWMTGGASSVPCSDTFAGLTAFSEPETKAMADYYATIADKINIQFSFHSYGQYLLTPFGFSGAPLPSNNADLQRIAAVTAAAIEATYGTRYTYGNSASVLYTTSGSTVDYFVGVHGTKLGFTFEFRDTGATGFVLPANQIIPNAEETLNGIIAFVAEAKTLGYV
The following text describes a protein:
Function:
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Sequence:
MPDELRAEKSFPSKPYDSLKNKSEFDRVYQKGFKKHNPFFSLFVLDLSQEPPKEKAGFKDPLFCRLKDKKTLYLLGLSVSKKVGNAVKRNLIKRRLRSLTLKHAALCQGLALVFVPRSDCYHLDFWALEKHFLEMLTSIKNYMNKALKDLKKGITHTYAKQ
The following text describes a protein:
Function:
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG
The following text describes a protein:
Function:
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.
Domain:
The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3); The CHD1 helical C-terminal domain (CHCT) binds DNA and nucleosomes.
Sequence:
MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGSQSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNSGSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETESDYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFKVANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGPTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDHRSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLDQRSPYGSRSPFEHSVEHKSTPEHTWSSRKT
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin.
Sequence:
MTSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLTATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDLTNKATGKLIAQGRHTKHLGN
The following text describes a protein:
Function:
Involved in endoplasmic reticulum (ER) stress response. Senses unfolded proteins in the lumen of the ER via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices bZIP50 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response (UPR) transcriptional activator, which then induces transcription of UPR target genes, such as luminal-binding protein (BiP) chaperones.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRSLRRVLLQLVLLAGVAFRGVRFDDAADAAAAAQGSSDLFELPSPSPTLALPGGGDEGASTEIIAAPWPGRHGLFTPPRSTSQPARAVVQPAADFGSQLQFYDNGTIQLVDLLSKLPRWQFSTGPPLSKHITTSKPDLNYVIYLDGSETSDLIEVHNGSGVRLPWKLEEFIAETPYIRDSFVTIGSKVSTTFVVNADSGEIIYKHSLPVALNEVGGPLVEEIPSKLDAARSGTSANIIVVVRTDYSISASDLGEHLFNWTRTSFTANYYARYGHQDMLAQSSCLRGNIPCIRTEGPPIKLYLPDSSSDNAIVLRPVNEVSAVDALEPLLPPKKLPQPAGESNVALDSAQNQTADIALGHFVPADTELTNSVTKFSYRWLFPTFLMLLIMACLVKLADASKYCRQFVIRFLKPFMRDEKLMDPRGKSEGTSKRRKARKKDGLINSTQIFSASDKEGNGTGGSTEAQSNKAHDSTNVELPNGLNGRQIGKLCVYSKEIGKGSNGTVVFEGSYGGREVAVKRLLRSHNDIASKEIENLIASDQDPNIVRMYGFEQDNDFVYISLERCRCSLADLIQLHSVPPFSNTKGTDIELWRQDGLPSAQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGPLRAKLSDMGISKRLQEDMTSVSHHGTGFGSSGWQAPEQLRHGRQTRAIDLFSLGCLIFYCITKGKHPFGEYYERDMKIINNQFDLFIVDHIPEAVHLISQLLDPDPEKRPTAVYVMHHPFFWSPELCLSFLRDTSDRIEKTSETDLIDALEGINVEAFGKNWGEKLDAALLADMGRYRKYSFESTRDLLRLIRNKSGHYREFSDDLKELLGSLPEGFVQYFSSRFPKLLIKVYEVMSEHCKDEEAFSKYFLGSSA