lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MTISYDEEFSSLMIRWRGSLWKAVLKDLIWFYAAYYAILGFQWYILDEKQKEYFTGWINWCEIGTQYIPLSFLLGFFVSVIVARWWEQFNWISWPDKMMMMVSACLPGKENQPVREAIARWSSLQSAIAWSGISVRTLKRFPTERHLVAAKLMTEEEYDLYMNTDAPQGKWFIPIIWIINLIRKQYQDKKIDSVQMQMLLQQVYSFRDGFAMLFVYDWVKIPLVVAIATYGYFFICLIGRQPKLDQKSMSTEITILFPIFTTFQMLFYLGWLKVGQFLMNPFGEDDDDFELNYVLDRNTAIAHMMATDLADQCPTIGKLDDPDYLELIKTIPHTRASFKIQDVIPKSHLASFRLCDKDMQLINPEDIEDENRAAEAKGQRQRLGGFVRAIEARRKKTTEEPLSEEAEHLNNGTEDGKDQCTAEFFFSQSALKDIGDYRPRPGPRPKVLQDEAFHPTTKVSRDPSRTIGPIIIGPGPKVDATTKISRDPSRTIGPIIIRPGPKVDATTKISRDPSRTIGPIIIGPGPKVDATTKISRDPSRTIGPIIIGPGPKVDATTKISRDPSRTIGPIIIGPGSPKLSGFKVPF
The following text describes a protein:
Function:
Negatively regulates TGF-beta signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MTSRPARPPQPAVMADLCKLVWRLGVFLAVWCSLIGLLSAVGAAAEETMTTTEGRSIKCYCSKHCPENQENGTCITKPNGRCFMQVESDLAGGEIVSHGCIGPEGTLLQCKAQVHSIPRSIQCCMDSDMCNLQLNATLPPSANDTPGLPPNAYYDPSIHHITLVISVTVCTTVLMLTIAFVYFRYKKRELGTRYDMEVGDHDETFIPPGDTLKDLIEQSQSSGSGSGLPLLVQRTIAKQIQMLHSIGKGRYGEVWKGKWRGEYVAIKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLRGNTLDRAGLLRLAYSAACGLSHLHTEIFGTQGKPAIAHRDIKSKNILVKKNGACCIADMGLAVRFIRYGDHSNPDADPSLLSGHSGWSIRTPGMSGVEEYWSETNEVDIAPNTRVGTKRYMAPEVLEETMNKNSFDAYKMADIYSFGLVLWEIARRCIVGGIVEEYQLPYYDCAPHDPSYEDMRRIVCIERQRPSIPNRWHTDEVLRPMAKLMSECWAHNPNARLTALRVKKTISKMMVEAQIKA
The following text describes a protein:
Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Not absolutely essential for activity in vitro, however it strongly stimulates activity. Binds RNase P RNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MVGGGGVKFIEMDIRDKEAYELAKEWFDEVVVSIKFNEEVDKEKLREARKEYGKVAILLSNPKPSLVRDTVQKFKSYLIYVESNDLRVIRYSIEKGVDAIISPWVNRKDPGIDHVLAKLMVKKNVALGFSLRPLLYSNPYERANLLRFMMKAWKLVEKYKVRRFLTSSAQEKWDVRYPRDLISLGVVIGMEIPQAKASISMYPEIILKRLKY
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
METQEPQLRNSQKSSKRKKKSTKSINTSSIIQDQINYNNFTPMETENININNNNPSNNNNNNNNNNNNNNNNNNNNNNNNNNMYNSNLNNNSIGYSQHPQNNMANNQSINQQQQQQQQQQSNFEDIYSDEYCENQMKFIEIYIKKWKENYIETMKANIEFHREEHQAFNEQLNDLKSERVFLNNYKESNLRIIESQQQQLQLVKNEIKSIEKNRDQLPLDLDFRKIKYDEESQKLSNLSDTIKSIEEHSNKLLNDISTPLLQFKKYLGLDFKKLENNEGLKFIFTHIDKNNYFKEFSISISLDKNTEDYFIVDCTPIIPNASQLIKTLNSTGNLSSFIKRVRKQFVNITNNISTSTTTATATKNSKNFNNINKQEKK
The following text describes a protein:
Function:
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVRERRDSEQRPSPEALLEAARREESASGKLKIFVGAAPGVGKTYEMLQSAHAKRKAGIDVVVGFVETHGRAETEALVRGLEVVPRKRLDYRGQTIEEMDLDAVIARRPQIALVDELAHTNAAGSRHPKRYLDVEELLSHGIDVYTAVNIQHTESLNDVVAQITHVRVRETVPDSVFDRADAIELIDLTPDDLIQRLREGKVYVPRQAERALEHYFSPGNLTALRELALRRTAERVDEQLLTHMQANAIAGPWAAGERILVCVSEDPRAAGLVRYTKRLADRLHAPFTAISIETRRSLQLSDDERDRLADTLRLAEALGGEALTIPAVGRRIADDVVNFAQGNNVTQIVIGKSTRSRWFEITRGSVVHDLVRRAGNITVHVIAGDDVPGEAAPKTAVQTAARTEPFDPLPYLKALGIVLIGLGAAELIQPRFGIENVDLVLLTAVVAVAVRYGLWPSLLATVAASLSYNFFFLPPIYTFTITDPTNVAAFVLFMVVAMIVSNVAARVRTQADTAIGRIRTTEQLYAFSRKLAGTATLDDVLWATAYQIALMLKVRVVLLLPEDGLLTVKSGYPPEDQLDQADLAAANWAWSNDRPAGRGSDTLPGAKRLFLPMRTGRGPIGVIGIDNDRTGPLLTPDQRRLLDALVDQGALAIERVLLVEDMDRVKRTVESERLRSALLTSISHDLKTPLASVLGAASTMRDLAGALSDTEKRDLLATVIDESERLNRFIANLLDMTKLESGAIVPNTALHDLSEIVGSALRRAAKILTAHKVELVLAADLPMLQLDAVLFEQVLFNLLDNAAKYSPAETTISIKSQRERDQVVLQIADEGSGIPPDEVESVFDKFYRVQKGDHVRPGTGLGLAISRGFVEAMHGTISAANRSDRSGAVLTIRLPVPAQTHALDTAA
The following text describes a protein:
Function:
Plays a protective role during endotoxic shock.
Subcellular Localization:
Secreted.
Sequence:
MKVVILMALLVLTAHCVPVSRFPGKIFLYCPFFNRKHCQRFCEFFKICRKPPLSRRTTVVPSFPLTTEADLSLTGGPLTPDRRGDSR
The following text describes a protein:
Function:
Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MATPEASGSGEKVEGSEPSVTYYRLEEVAKRNSAEETWMVIHGRVYDITRFLSEHPGGEEVLLEQAGADATESFEDVGHSPDAREMLKQYYIGDVHPSDLKPKGDDKDPSKNNSCQSSWAYWFVPIVGAILIGFLYRHFWADSKSS
The following text describes a protein:
Function:
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade.
Sequence:
MSQLRFWLQFAALNKDPSCLEDLSNASVFSSSVDSLSDIPDTPDFLPADSLNEVPTIWDVSTTSTTRDKLFLPSVPFSALEDPVTAVSSTPLLVSYQSHSQPEEEEGEDEEEAEELGHAETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPTSDNGTLSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGIIVENYLRGRKKALWFSASNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEGVLFATYSALIGESQAGGQHRTRLRQILQWCGEAFDGVIVFDECHKAKNASSTKMGKAVLDLQNKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLSPVFEQVYNRAARLWAEALSVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVVIGLQSTGEARTREVLDENEGRLDCFVSAAEGVFLSLIQKHFPSTRRRRDRGGGKRKRRPRGRGPKASRLTLEAAGVIRISDGSSTESDAGLDSDFNSSPESLVDDDVVIVDAPTLPTDDRGPLYPLQRDLQGPGVLERVERLKQGLLAKVRALGRELPVNTLDQLIHQLGGPECVAEMTGRKGRVVSRPDGSVVFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGARALSRVLATIMGQTNNRVPLPQGYPGGDAAFFRDMKQGLLSVGIGSRESRSGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEIDKKEGRYDMGILDLAPGINEIHEESQQVFLAPGHPQDGQVVFYKISVDRGMKWEEAFTRSLELKGPYDGFYLSYKVRGSKTSCLLAEQNRGDYFTVYKPNIGRQSQLETLDNLCRKFHRVTPEEAREPWESSYALSLEHCSHTTWNQRCRLAQEGKCCAQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDKKKQVGIKIPEGCVHRVLQELQLMDAEVKRRSAHGLAARPPTPRAITLPCGPGEVLDLTYSPPAEPFPAPPRFAFPSLPPPDPSSLMLGTRDNATNPVELAHQGCDINFREVLEDMLRSLRAGPTETPAPLVGVGGGGGGGTERQSVIHFSPPFPNS
The following text describes a protein:
Function:
Broad-specificity nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. For this activity shows the following substrate preference CDP > UDP > ADP > TDP.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm. Nucleus.
Sequence:
MTSQEKTEEYPFADIFDEDETERNFLLSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITEIPSLSQDAMTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEVIENHRKKKKEAQKDGKGEEEEEEEEQEEEEAFIAEMQMVAEILHHLVQRPEDYLENVENIVKLYKETILQNLEEVMAEHNPQYLIELNGNKPAEELFMIVMDRLKYLNLKRAAILTKLQGAEEEINDTMENDELFRTLTSYKLIAPRYRWQRSKWGRTCPVNLKDGNIYSGLPDYSVSFLGKIYCLSSEEALKPFLLNPRPYLLPPMPGPPCKVFILGPQYSGKTTLCNMLAENYKGKVVDYAQLVQPRFDKARETLVENTIAEATAAAIKVVKEKLLRELQARKQAETGLREFQRQYEKMEFGVFPVEATHSSIDEEGYIQGSQRDRSSSLVDTEEAKTKSENVLHDQAAKVDKDDGKETGETSSFKRHSQDASQDVKLYSDTAPTEDLIEEVTADHPEVVTMIEETIKMSQDINFEQPYEKHAEILQEVLGEIMEENKDRFPGAPKYGGWIVDNCPIVKELWMALIKKGIIPDLVIYLSDTENNGKCLFNRIYLQKKSEIDSKILERLLEELQKKKKEEEAARKATEEELRLEEENRRLLELMKVKAKEAEETDNEDEEEIEGDELEVHEEPEASHDTRGSWLPEEFEASEVPETEPEAVSEPIEETTVETEIPKGSKEGLEIGKLSETVVLPEFPEDSYPDVPEMEPFKEKIGSFIILWKQLEATISEAYIKILNLEIADRTPQELLQEVVETMEKPFQYTAWELTGEDYEEETEDYQTEAEVDEELEEEEEEEGEDKMKERKRHLGDTKHFCPVVLKENFILQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEEPLKAPPLRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSEDEQAAKQELEELAIQANVKVEEENTKKQLPEVQLTEEEEVIKSSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFPDAAVFIQVDDQDIFDRLLPAQIEKWKLKQKKKLERKKLIKDMKAKIRVDTIAKRRAELILERDKKRRENVVRDDEEISEEELEEDNDDIENILEDEFPKDEEEMSGEEDEEQETDAIERLRGELAEKFEADTHNLQIIQDELERYLIPIISVNGARKNHIVQYTLNMKLKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPIKYIRQPKPKPTVPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPYPLHNSAQIIAVNNLKYRKNIDEIRQYYQEQHQNWYVIDGFHSKWWVWNEVIKNVQMVNKYMQTYLERIKAGKAACIDKLCITPQELLSRLGEFGQFCPVSLAESQELFDCSATDSLEFAAEFRGHYYKMSSQEKLNKFLENPELYVPPLAPHPLPSADMIPKRLTLSELKSRFPKCAELQGYCPVTYKDGNQRYEALVPGSINYALEYHNRIYICENKEKLQKFLRSPLKYWEQKLPHKLPPLREPILLTSLPLPGYLEQGIATSLIKAMNAAGCLKPKFPFLSIRRSALLYIALHLKAFNPKGSEYTRKKYKKKMEQFMESCELITYLGAKMTRKYKEPQFRAIDFDHKLKTFLSLRNIDPING
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MASEEQPRWTRLPIRTRPHRNPLAENDDEHPECPAQFERRFSEFYPGMVNPVVEFVDVGCAFGGMLFSLAAVFPATCMMGLEIRPKVVSFAQEKALALRQENAASLTQHYRNVWFEQMNVMKFGSNCFTKGQLSRLFFCYPDPHWKRKNIRRRIISPGLVQEYAYWLRHGGLVYTVSDVAELEEWMVQCLDDSPLFRRLAEAELCTPEHKQVLEIVTGASEDAQRTARKGLQKHFAVHMRI
The following text describes a protein:
Function:
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFNYEEGDADQAAMAAAAAYRALLDYYANAPSAAGHIVSLNVAPYNGTGNGGTVSLAGNATSSYGDDDRDGYMDTEPSDLVTELAFSLGTSSSPSPSSTPASSSSTSTGMPVWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGLPWRRGAGASGGVGGAAGGGLSASQAGAGPGAYASANTNISLNPGLAMGMGTWRSRSRHEFLNAVVTTNSAAAAVNSPQL
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MQMAKKVAEEVVSILDEAMRNSPIFLAVSTGNVDALCRAYADGESLSVCDMTGNNILHVAIQRRNRLMVRAVLVLSYDLVLWEKKNDGGMTPLDLATKELREDIAIFQSDKDTRGAGCDWKRNTQLVEEKMDMDDVSNEHVLLSLDGGGMKGLLELQTMLLIERRLGIPLMGVVDWIAGTSTGSIIALVLAQGRSVQWAHQLYFRLGATIFKKGDSYVPKYSSKNLEECLIEHIGTAPLSSIQSIKVVVTASKIDTSPPSLLLLRSYLPRVPNVVYAAEGFLDPERTPIWKAARCSSAAPIYFTSCNGLADGALCTNNPCAVLISDFYRMKKIENVNGVKNDDQIHCMISLGTGQDPRQAQPVDVSLQSFSPNALIDTIKKSTNLIQMFIMQCVSSDGPSVEYSKEWAHSQDVPFFRIQPLLDKKVVLDEKRPSVLMDVLWQTEVHNRTRIPHQINQIVDLFRSIHTKRGINNNLNPGAEKETEMTPRTESIASNREFSGNKKKKPAARKDKNKVLQKVNPFDLKFTKSKHNVLGKNKNQAVGAPMKSRKRALDSREKTLALEYKSMNKSNKLMDKRLGEKDRTLTEEEKAAKRFTEERLSSMKKKDIFNLNDDAEEETLTHGGRALTAIEKFDRVIESDDEDEGMTSEMAASIQFGGGDLDKGKPKDRKDLIAEMVSKSKQIKLEKSNAKDEQMQLTENLDGRLKALMMKGSLIQQKKEDLKKKIRDDYDDILTSLKFTNDKVTAPTNAKKTEAEEAEDEKKRLEKLEDDRKMRMTTKTSSTHFSADDDSVKRKSERPRKENNGFELIFDEEGKQINKKVDKNEKRRLTFDEESDCDDEELEDEEEDLEELMESGEDEDEEEEEVEEPPKKKSKKKEDTKKKNGKIVLADLPFTFSAPNKYADFMKLIDSMETQCIPTLVERLVKCFHPSLKEGNKAILERVFLFLLRLFTETSRKVPTKENIERIESLFLPIHTLLKLNREWGVKCIRSLIRSEWRRVEKGGISSPPTFTLSSSIRLVSLLFPVSDVWHPVCTPTLLVATRALVKYPLVCLSTLTRQLFLLSTLSEYINEIHRFIPEAVSFLRGCLCLAVEGETRVPSTVFPVSFPHSKMLVVDKPSSGSITPIVPEEVFTEHAKKGLVDTPLNRIRVLKVVIVLLRKFMLIYLNHPTTFSIIFKPLSSLLSRIPLSHLPSDLKEDIVDLISSMDSNCKEHEKIVHVSRKKGEQNMLMMVEPAWDDDFDPENKFKNRQNAPDAMSKKMSKMIKKEKRGAIKEIRKDNTFIAHKKAQSNAALDRDRKRKTKRLMASLQSQEGEHRRMEVKKKWQKR
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MEPRRERRKKLVRRIPKEGIKNTTNTESAVVDETNSDKQVSCSNELRKLSGSSINTDRQKTLRISTVRPSILCLKKKLIVLDLNGLLVDMVSPPPKYCKADAIIGRKAMFKRPFYLEFLNFCFEKFEVAVWSSRTFQGYAVLLQRVQGANTKQLSHFCSTSRQLLHHC
The following text describes a protein:
Function:
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. At 1 uM, the synthetic peptide reversibly blocks mammalian nAChR alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND and, to a lesser degree, alpha-6/alpha-3-beta-2 (CHRNA6/CHRNA3-CHRNB2). At 10 uM, it reversibly blocks nAChR alpha-3-beta-2/CHRNA3-CHRNB2. In vivo, intramuscular injection of 10-20 ug of the synthetic peptide in goldfish causes death, while intravenous injection of the same doses in mice causes unconsciousness.
Miscellaneous:
MISCELLANEOUS: Negative results: has no effect on nAChR alpha-7/CHRNA7, when tested at 1 uM. Also has no effect on nAChR alpha-3-beta-4/CHRNA3-CHRNB4, alpha-4-beta-2/CHRNA4-CHRNB2, alpha-4-beta-4/CHRNA4-CHRNB4 and alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4) (at 10 uM). Does not inhibit potassium channels.
Subcellular Localization:
Secreted.
Domain:
The cysteine framework is XIV (C-C-C-C).
Sequence:
MGMRMMFAVFLLVVLATTVVSFNSDRASDGRNAAANVKASDLMARVLEKDCPPHPVPGMHKCVCLKTCR
The following text describes a protein:
Function:
May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus.
Miscellaneous:
MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGATGVLLCVVLHFLQMVTQSSEKFTVTGLQRPVLAPLGGNVELSCQLSPPQQAQHMEIRWFRNRYREPVYLYRNGKDLHGETISKYVERTELLKDDIGKGKVTLRIFKLTADDDGSYHCVFKVGEFYEEHITEIKVTATSSVMYILMQPPNIKGVMLECHSGGWFPQPHMEWRDNKGNIIPATSKAHSQDENKLFNMTMTLLIEASSHRSITCYLQNLLTHQEESISIVLSGELFSWKRVWIMILTTIGFMMIAFCMTYCVQQHLLYGTFSKGKCHWLKSTMIFMFSVIAVTGVMLILHLKQRVPVSDQHFELDTLWLEDISVILCVLIVFIIKLISFIYFRLEGDHQGWSLPPYLSATPTAAICRLAVPEYSRGHLQLDSEDDLAGMGPSPFFITPCF
The following text describes a protein:
Function:
May be involved in DNA replication and thus regulate cell proliferation.
Sequence:
MEQLLSMGFSEDLASEALAATGGHSPLAAADWILTRSSSSSSVPPPPLPPSQSPSTQPCLERFFASSFAIPKTLNPSSSSSAPKTPNPSTSTSSSSPSSLPIKRRHPSAAAPLSDRMRPGTLDSIVGQDHLLGPSSLLRSSLLPSLVLWGPPGSGKTTLARALAASLPGSLYTFVPLSAVSAGVRDLRDAIDGARRARSHGRRTVLFVDEIHRFSKSQQDSFLPAIEDGSIILVGATTENPSFQLTTPLLSRCRVLSLQPLKPQHIEALLRRALSDPEKGLQVTTQAPVSVNQEAIDFLSLHCDGDARVALNALEIAAMLAASRKLHDNKGNLAVTLDQAKEAMQCKHLAYDRAGEEHYNLISALHKSMRGSDADAAIYWLARMLEGGEQPLYIARRLVRFASEDVGLADPSALSHAVACYQSCHFLGMPECDVCLAQCVTYLALAPKSVAVYRALGEAKRVVKESSGGNEGVPLHLRNAPTKLMKDMGYGKDYMYPPDHKDCSSQTYLPPSLLGHKFLDWPPQDE
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
METRLEVLLREPNPLFTRWLERWLREAERREQKSQFSLRQALESLKSYPLPLASGRDCSILRGFGGTLCQLIDEELRHHRGLQLLPQEAVVQERYEQQVQAVVRKVQEKQLEHQKRQNKCDRPRKLTKKDLAELAALEERERVVRMKPGQFQLLLLVDTQETSGKNKRVLDQTRSYLESLGARHEVRRLTIGDFLWVAQDQEGNELVLPYIVERKRMDDLASSIRDGRFHEQKHRLQHCGLQHIIYLVEDYGDNEQLGLPLDSLQQALTNAKVQTGVRVVRTANHYRSMSYLAGMSRTLGQIFAGKKLHSVDRGAIDQSTCLLTHSDLGLLKFRALYEDSAKNAQLTVREVFVQQLLQLHSLSLERAMAIVERYPTPRWLLDAYAECADQKQARLLLASIPCGPLERPLGDKISQCLHEFYSTHFR
The following text describes a protein:
Function:
Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.
Sequence:
MNFKPIKPKKISTQIAEQIRSSILAGEFTPGEKLPPERELAEMFGVSRPSVREALNILAAAGLVESYQGGGTIVKSLMDAASGPPLSEIIKVEQERALDVIEVRKCMEAWTAYYAAQRALPDDVRKLEGIVWNMEANLNGLKPSEDLDANFHIVIARSTHNVVWLHLMQTIFEAMKEFQRSVWRAVYLTEEDHRTLFAHHKAIFEAIRDKDCERARNAMLGHLTFAEKRSSIYVNQSRQDR
The following text describes a protein:
Function:
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB subunit has 5' -> 3' nuclease activity but not helicase activity.
Miscellaneous:
MISCELLANEOUS: Despite having conserved helicase domains, this subunit does not have helicase activity.
Sequence:
MTLHAYLGRAGTGKSTKMLTEIKQKMKADPLGDPIILIAPTQSTFQLEQAFVNDPELNGSLRTEVLHFERLSHRIFQEVGSYSEQKLSKAATEMMIYNIVQEQQKYLKLYQSQAKYYGFSEKLTEQIQDFKKYAVTPEHLEHFIADKNMQTRTKNKLEDIALIYREFEQRIQNEFITGEDSLQYFIDCMPKSEWLKRADIYIDGFHNFSTIEYLIIKGLIKYAKSVTIILTTDGNHDQFSLFRKPSEVLRHIEEIANELNISIERQYFNQLYRFNNQDLKHLEQEFDALQINRVACQGHINILESATMREEINEIARRIIVDIRDKQLRYQDIAILYRDESYAYLFDSILPLYNIPYNIDTKRSMTHHPVMEMIRSLIEVIQSNWQVNPMLRLLKTDVLTASYLKSAYLVDLLENFVLERGIYGKRWLDDELFNVEHFSKMGRKAHKLTEDERNTFEQVVKLKKDVIDKILHFEKQMSQAETVKDFATAFYESMEYFELPNQLMTERDELDLNGNHEKAEEIDQIWNGLIQILDDLVLVFGDEPMSMERFLEVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKQHVYLVGMNDGTMPQPVTASSLITDEEKKYFEQQANVELSPTSDILQMDEAFVCYVAMTRAKGDVTFSYSLMGSSGDDKEISPFLNQIQSLFNQLEITNIPQYHEVNPLSLMQHAKQTKITLFEALRAWLYDEIVADSWLDAYQVIRDSDHLNQGLDYLMSALTFDNETVKLGETLSKDLYGKEINASVSRFEGYQQCPFKHYASHGLKLNERTKYELQNFDLGDIFHSVLKYISERINGDFKQLDLKKIRQLTNEALEEILPKVQFNLLNSSAYYRYLSRRIGAIVETTLSALKYQGTYSKFMPKHFETSFRRKPRTNDELIAQTLTTTQGIPINIRGQIDRIDTYTKNDTSFVNIIDYKSSEGSATLDLTKVYYGMQMQMMTYMDIVLQNKQRLGLTDIVKPGGLLYFHVHEPRIKFKSWSDIDEDKLEQDLIKKFKLSGLVNADQTVIDALDIRLEPKFTSDIVPVGLNKDGSLSKRGSQVADEATIYKFIQHNKENFIETASNIMDGHTEVAPLKYKQKLPCAFCSYQSVCHVDGMIDSKRYRTVDETINPIEAIQNININDEFGGEQ
The following text describes a protein:
Function:
Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.
Subcellular Localization:
Nucleus.
Sequence:
MAVPNCEVSKPRRIKALLSSFLKGVSREEKKQSENKEVISEPTEGDDADGFADGFVVVDEISSEQSSTVQPLNQELFFNRVETFSISSWFAKPDEVSPLRCAQYGWENIDVDSLKCVSCKEVLYGGLPPKWETDSYEKACKKLEESLKAGHSKICPWQSNPSPASFLEVNLVSTQKAVDDFLHRVASIRCFGTSIPAVDLSCLQQVEENEDVLSRLVTGVLGEEPTSDYKERIELVCFMALSGWSRSSPEVSQSPTMSCEFCRRNVGLWNFTPFEQNAKTTNEDESEPTAKRLKVDKGLFNPIEEHRSWCPWTKPASVTYTVRSLPPQDKNQDDNTPVRPAWHGLQVLLHERSSPNKQGPLTNKQVTPPSQAWKAVRRITNFWQSRSAAHKT
The following text describes a protein:
Function:
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MAFAETYPAASSLPNGDCGRSRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVRKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Miscellaneous:
MISCELLANEOUS: Present with 9410 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLSLRQSIRFFKPATRTLCSSRYLLQQKPVVKTAQNLAEVNGPETLIGPGAKEGTVPTDLDQETGLARLELLGKLEGIDVFDTKPLDSSRKGTMKDPIIIESYDDYRYVGCTGSPAGSHTIMWLKPTVNEVARCWECGSVYKLNPVGVPNDDHHH
The following text describes a protein:
Function:
A probable ATP-dependent DNA helicase implicated in DNA replication, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.
Subcellular Localization:
Nucleus.
Sequence:
MPVYRIRGVDVDFPYDAYDCQITYMDRVLESLQQGKNALLESPTGTGKTLCLLCSALAWRRTFGEFLRGGGGGGGGGGGGGGGGSQQPPYGSQPSGSQHSGGSASQSSRYPVIIYASRTHSQLRQVIKELKATSYRPKMAVLGSREQMCIHEEVSKLRGRQQNNACHYLCKKRWCRHHNSVAEFMRNNSELGSEACDIEDLVNIGRTKGPCPYYISRELSKSVDILFAPYNYLIDPGNRRSLNGIPWDNAVLIFDEAHNLESICADAASFDLLPNNLSSCIAEAQECIQLCSAKRTFENSADKQFDPENYAILKALLMALEKKISEVVIDSKELGHTKPGNYIYEFLSELNITSETSKKLIDTIDGASLLLEEGNSAETGPGMKAKATVCRLETIRDILDIIFRGGGQSHAKYYRFHVNECQQNSGDALKVLGKVSRTLSWWCFNPGLAMEEFLKLGVRSIILTSGTLSPLDSLALELNLEFPVRLENPHVIASDQIWVGVVPVGPSGHPLNSSYRTRETLKYKQELGITIVNFARIVPDGLLVFFPSYSMMDKCINCWKDRNHENSSDEHTIWQRICKHKQPVIEPRQSSNFPNAIEDYAAKLRDSSTTGAIFFAVCRGKVSEGLDFADRAGRAVIVTGMPFATPTDPKVRLKRDYLDKLGSASNKNSKALTGEEWYVQQAARAVNQAVGRVIRHRHDYGAIIYCDERFVWQNYQSQMSYWLRPYIKCYKKYGEVVQGLTRFFRDKVSIDSSKPNETDFNDNIVLLADKHKPQETISALAVTTANENQRTALSVNPTTKRSNYIKFAQITPANRSTLSMKHGCSSTSQLLYSGDKLSTDAQVIDLAADVATSHLAGYRFKSLGPKKAKVMVGSKDVCFDDGSPKLQHNVESRALAGCLGEQSTASSKKSNITHAPGNSGAIHEKSGGQESNAGPAFLKLAREKLSTAEYRDFVEYMKALKLKTMHIKDSLDAIAKLFSSPERLPLLEGFRVFVPKNHLSLYEQLVQSYTVPNT
The following text describes a protein:
Function:
Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation. Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Cell projection, growth cone.
Sequence:
MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLVCTFSLTLTWLYFWWGVHNDYDEFNWYLYNRMGYWSDWSVPILVTSAAAFTYIAGLLVLALCHIAVGQQLNLHWIHKMGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHIGALVAITALSWIVAGQFARAERSSSQLTILCTFFAVVFTFYLIPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTVMSFRKALEQRLYGLQADITISLDGVPFLMHDTTLRRTTNVEHLFPELARRPAAMLNWTVLQRLNAGQWFLKTDPFWTASSLSPSDHREVQNQSICSLAELLELAKGNASLLLNLRDPPRDHPYRGSFLNVTLEAVLRSGFPQHQVMWLFNRQRPLVRKMAPGFQQTSGSKEAIANLRKGHIQKLNLRYTQVSHQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHTLSRVPSPLWIMPPDEYCLMWVTADLISFSLIIGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISDGVEVSDELSVCSDSSYDTYANANSTATPVGPRNAGSRAKTVTEQSGH