lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNQNQIQQLTSHLSQALDQNYDVVNMDAVLSVICALEGTTITKEQLEATRLAKYINQLRRRTKNEHLARRAKSLLKMWREMVGIQQTANDSQHHHSQPTSLPTPPSAHFYKYTAGSADSNLTETVVHLPVSPSVPSHRTISDLHSNIDSSEPPPAVLPSQHQSNFLNLINNISKCEREESNSSMLIQAHKQPQSQQFQNRPLGLPLPFISEQSLNSVSISSDVGNDKKGEASIVIDIVTDSDENDNESASTIQGKPTAAASAPFTISPAPCPRPKKFKKDKKHKERDRSKSSLLAQNELIGQHSSRYSAKVKEGQSQTAQATDSEIFSLSNSSMSSILSGDAALLNPQHKFRANASELTFTGRFKPVNHLDSANQDNSALPIGQNIVFRQNESERPIFEDSITNDSSTSCSRLSPPTVEERRKSDKIDDSIRQQIATSIQMPMPSIGLGHESNSRTEYLENSSKSQVPKKRGRKKGSKGVDAVIAKESSSLSQQIFFGVGSTVKKVKTTKELFSEIQSRKLITAVQSPTSNISNSSISRELTTRALMPRPTSSCSDTSIHSPQIMETYSGNVTLMGVDKFSNKNEDAGNTDSDTITSEPSQDSNKSQEIKECTSLDSNSNSLQTLSLAKKSMHTSKSENYSDVTTQLMHLIHSIKGPLSVYEVEKLYRAQIVPCTCLVIEEICNPFGEPINLSSDNGVGDPKSDSNNDNVSRHKKQEEQLPKLERLSDNDFSMDTPQKPVKSIFDLDFDEDEDPLQSIINDIRMPPTKLEETKENADLKNALAHLPMNISSLDVASVNADTVQNQINSHNQEGETSEEQNVAIPVFTCHEDPDCVAKQRFHVQTNKVNNFHINALHNFYIPNINGNWDSIDSSIVSESTITDFLNTLGSYTVTDGADVVPKYGSLTYDRIRKDLSSIKFTSSFKTRPLKSFMPPFLGVAKCLPTCRLARSSFKKKQIQSPPPPLIVIPSTIEGLDPDIMQKDYNGGSPLKVDVDVLVSGHDNNESNVQMQVNLQTKSDPTLSYNLLKLANDELPFEETEPNDKGSEYENQDNGRFSSSSNSSCSNSSNSSLKKTQDSINEKLRNQRSQRYRVQSVEEETNRKRRGKNRKKRNIKENPPIKRIKISLNGTISNLSSSNNSSSSESETETGLENENEVENDYENNNDEEYAVVQRPTCGDGASNNHIVMTIKKTPSKINSPANSMSATSPINASETRNVKNAFSDSNRPNLLTSSTSIAPLYQIDGGRRLLLSKKFSRRPHRRRRYRQCRRKSDLQRKAIDLELKHLFTYKTKPDLDIGSAIKLHKKLFFSHELCKQNTAGRKERILNYSSSSSSNYDDDESDLDGLSSEETAADLKENVNTFNKYNLNIETDNTSAERTVSEDPLKIEEDPYLTSSSNDVTDSDNESDNHEVFDEVAKRVEADEFNELHNNGMLTSFNSISVENQLINEPTLMAVSGSVDTPAPQSNASLASLQNENCDDVNNLCYNNNNLDVIKHSLAASPILNDINYKNVISNTSPRVLANKFSDCIPQNIGNSELSPPIPLPCAEYQTGIRPAPLTDLALSSYADFRCTRIQQFKEWHQVLQLQSYNNEPLIVLPYVVLE
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).
Subcellular Localization:
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Sequence:
MYTSIYITDSKKNLVFEYLLTSQAPTFQQLCSKIAGRDAAMDAMVAISKDMSLYRQAVGPEKLWYWALCQACGDPLEPQMFLAQYHQVLIEYFDKEALTVKKLVNNADRLALLLHAMLDAGEVAVTDSNRLRQLVPLRNDLSTILNSATKTLANTVKYADSKQLFGAPVATGKVEAGQTVPWRTADCRYVNNEIYVDLVETVNATLRQKGSSLTLINGSLSGKIDVKCYLSGNPTVQLKLRTSGHPLDNSALHRCVELGEAGVATMNFVPPDGRFTLAEYAIDLSAISQAARRLTNLGLVTVSLASGLGQHRDEFEIKVIIGNSTQVAAIEDLRITVYFPDISDAAKIKILRTTHGGWESDLSRVRGVWAFDKQTAVGSVPVLRGCVENPESTPHAPPVFPSHLAVSYSHVGQLPSGIRVDTIALSDLPPGSKPFKGVKYTSRAGDYIVRA
The following text describes a protein:
Function:
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGELQFKWLFWRSFAESGGTFQTVLIFLFIPYSLTVDYRATPVLSDTTFVWVWNVPTEACVENVTEPIDLSFFSLIGSPRKTAIGQPVTLFYVDRLGNYPHIDAQQTEHHGGIPQKGDLTTHLVKAKEDVERYIPTDKLGLAIIDWEEWRPTWMRNWTPKDIYRNKSIELVQAADPAINITEATVRAKAQFEGAAKEFMEGTLKLGKHIRPKHLWGFYLFPDCYNNKFQVDNYDGQCPDVEKKRNDDLDWLWKESTGLYPSVYLKKDLKSSRKATLYVRYRVLESIRVSKVSDESNPVPIFVYIRLVFTDHVSEYLLEDDLVNTIGEIVAQGTSGIIIWDAMSLAQRSAGCPILRQYMKTTLNPYIVNVTLAAKMCSQTLCKEKGMCSRKTESSDAYLHLDPSSFSINVTEAGKYEVLGKPEVKDLEYFSEHFKCSCFSKMTCEETSDMRSIQDVNVCMGDNVCIKATLGPNSAFHLLPGKGLLLMTTLAHILHHLPHDIFVFPWKMLVSTP
The following text describes a protein:
Function:
Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.
Sequence:
MKEEMSSVDIRYIVRELQWLVGSRVDKVYHDGDEVRFKLRTKEGRADLILEAGKRFHLTSYIKEAPKQPSSFTMLLRKHLGGGFIDAIEQHQFDRIVKIRIGNYTLIGELFRRGNIILVDSENKIVAALRYEEYKDRAIKPKAEYKFPPARENPLEVSFERFLDLMREEPELELVRALARKLNMGGMYAEEISLRAGFEKTTPVKELSDEDLKRVYDEMIRTFNDEPKPNIVFKDGVMHDVVPIELKIYEGFEKRYFPTFSEALDEYFGKITLEKAKIEQTKKLEEKKRGLMATLRKQEEMLKGFEKAMRENQEIGDLIYANYTLIERLLEEFRKATETLGWDEFRRRIDEGKKTGNKVALMVKGIDPKEKAVTIELDGKKVKLYLEKSLGENAEIYYEKAKKFRHKYEGALKAYEDTKRKLEEIEKLIEEEQKKELNVKKLERRKRKWFEKFRWFVSSEGFLVLAGKDASTNEVLVKKHMEDNDLYCHADVYGAPHVVIKDGQKAGEKTIFEACQFAVSMSRAWSQGLYSADAYWAYPNQVTKQAPSGEYLGKGAFMVYGKRNWMHGLPLKLAVGVINYDGEEYVVCAPVEAIKAHTDKYIVIRPGSMKKGELVKKLRGILKKWGYEVREEDLNAILPPGGGEIVEVVG
The following text describes a protein:
Function:
Together with PhnH, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.
Miscellaneous:
MISCELLANEOUS: The sequence shown is that of strain K12.
Sequence:
MHADTATRQHWMSVLAHSQPAELAARLNALNITADYEVIRAAETGLVQIQARMGGTGERFFAGDATLTRAAVRLTDGTLGYSWVQGRDKQHAERCALIDALMQQSRHFQNLSETLIAPLDADRMARIAARQAEVNASRVDFFTMVRGDNA
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHFRRRKRLQWNRILFLVSVMFLCSLYQLSVNHNVDTGPWTETELEDPISVREIQEKELISVTVRELGNQSIPTATTTSTTSTPTTEKITERTKIRHCIHVDPDPITPPIKPRPTTALTTTTEKTTRPTKPPLPHAKGEYPEDLFSIEERRRGWVSLHIFGMMYVFVALAIVCDEFFVPALGAITEKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILYLTWWPLFRDVSFYILDLIMLIIFFLDNVILWWESMLLLLAYGLYVAFMKLNVQVEALVKQQLSKQRCLVKVMALEDTSKKGNGAVAQDEPKPPEDNNRLKLKPFLTRGGSSASLHNSTMRSTIFQLMIHTLDPLGEAKFKDKAEIMNNLAKAKVETEAKKGLKVKDDRDDADLPNTVNVQVTPATGSEPSRDADDEGMDKDDVQKRAREGGGGGDSSGNSSSGDDSDDDSDDEDSDDDDDEEEEEVDEPLSLEWPETKRKQITYLLLLPIVFPLWLTLPDVRILKSRKYFVVTFLGSIMWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWFLFSVFNGFSPVAVSSNGLFCAIVLLFLMLLFVIFSIAACKWKMNKFLGLTMFTLYFVFVIVSVMLEDRIIVCPISI
The following text describes a protein:
Function:
Exact function not known, phosphatase 2A performs an essential cellular function.
Miscellaneous:
MISCELLANEOUS: Present with 4110 molecules/cell in log phase SD medium.
Sequence:
MDMEIDDPMHGSDEDQLSPTLDEDMNSDDGKNNTKARSNDEDTDEELEDFNFKPGSSGIADHKSSKPLKLTNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRPGEPTVTRKTPDYFL
The following text describes a protein:
Function:
Primarily required at the G2/M phase. Essential for viability: involved in nucleolar processing of pre-18S ribosomal RNA as part of the ribosomal small subunit (SSU) processome.
Miscellaneous:
MISCELLANEOUS: When overexpressed, has a role in the structure of silenced chromatin. Overproduction causes derepression of gene expression at both HML and HMR, as well as at the rDNA locus and at telomeres.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVRKGSNRTKTSEVGDEINPYGLNEVDDFASKREKVLLGQSTFGDSNKDDDHSLLEDEDEEEVLAMDEDDESIDEREDEEEEEEEELDGAAAYKKIFGRNLETDQLPEEDEENGMLDNENAWGSTKGEYYGADDLDDDEAAKEIEKEALRQQKKHLEELNMNDYLDEEEEEEWVKSAKEFDMGEFKNSTKQADTKTSITDILNMDDEARDNYLRTMFPEFAPLSKEFTELAPKFDELKKSEENEFNKLKLIALGSYLGTISCYYSILLHELHNNEDFTSMKGHPVMEKILTTKEIWRQASELPSSFDVNEGDGSESEETANIEAFNEKKLNELQNSEDSDAEDGGKQKQEIDEEERESDEEEEEEDVDIDDFEEYVAQSRLHSKPKTSSMPEADDFIESEIADVDAQDKKARRRTLRFYTSKIDQQENKKTDRFKGDDDIPYKERLFERQQRLLDEARKRGMHDNNGADLDDKDYGSEDEAVSRSINTQGENDYYQQVQRGKQDKKISRKEAHKNAVIAAREGKLAELAENVSGDGKRAINYQILKNKGLTPKRNKDNRNSRVKKRKKYQKAQKKLKSVRAVYSGGQSGVYEGEKTGIKKGLTRSVKFKN
The following text describes a protein:
Function:
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.
Subcellular Localization:
Cytoplasmic vesicle, phagosome. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome.
Sequence:
MKEVPTCWWCPEQQALGLDLVMEVEPPLYPVAGVAGPQGDEDRLGVHDGPEAPLDELVGAYPNYNEEEEERRYYRRKRLGVVKNVLAASTGGTLTYGVYLGLLQMQLILHYDETYREVKYGNMGLPDIDSKMLMGINVTPIAALLYTPVLIRPKVLMSLPLYRFFGTKWMMFLAVGIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMSQKYYEYSHYKEQDEQGPQQRPPRGSHAPYLLVFQAIFYSFFHLSFACAQLPMVYFLNHYLYDLNHTLFNVKSCGTKSYGILNGFNKTVLRTLPRSRNLIVVESVLMAVAFLAMLLVLGLCGAAYRPTEEIDLRSVGWGNIFQLPFKHVRDFRLRHLVPFFIYSGFEVLFACTGFTLGYGVCSMGLERLAYLLIAYSLGASAASVLGLLGLWLPRSVPLVAGAGLHLLLTLSLFFWAPAPRVLQHSWIFYFVAALWGVGSALNKTGLSTLLGILYEDKERQDFIFTIYHWWQAVAIFVVYLGSSLPMKAKLAVLLVTLVAAATSYLWMENKLQQGLVPRQPRIPKPQHKVRGYRYLEEDNSDESDVEGEQGQGDCAEEEAPQAGPLGAEPAGPCRRPCPYEQALGGDGPEEQ
The following text describes a protein:
Function:
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MAAKGACSGSRGFYFNTVLSLARSLAVQRPAVFEKVQKLLCMCPVDYHGVFQLDERRRDALIALGIFLVESDLQHKESVVPYLLKLLRGLPKVQWIEESNSRKGKGTLPVAETFSFCLVTLLSDVAHRDQAFRGQILETLMDVMQCLLGMCQSPQIQDKEYLCKYAVPCLIGISRAFGRYSNTEESLLSKLFPKVSPQSLKAPEELEGIRRRSFNDFRSILPSSLLTVCQGDSLKRKTSSVSSGSQVSPDHIVPPPGSPAGSTIPYFEGSYLPDGSAVDPDYYLTTISSSFSVSPLFTGVNNKDFDMPQDILRQLLHMVKQIVTDLFLSSLDMLIAEITEANASVNLYYKTFSDPLYVAMFKMLRDTLYNVKDPHTSFVKEIHDFVLEQFNSSQGELQKILHDMDRVNNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIRLSEKLQSKTSSKVIIAHMPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYQTGANDIKISVTNEHSESTMSIMSGKKSQASMYEQLRDIAIDNICRCLKAGLTIDPVIVEAFLASLSNRLYISQENEKDAHLIPDHTIRALGHIAVALRDTPKVMQPILQILQQKFCQPPSQLDVLIIDQLGCMVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQGEHQIDDLLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFSVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELNELRSTIISILDPAPEVSALINKLDFAMSTYLLSVYRLEHMRVLHSTDKDRFQVMFFYFEDKAIQKDKSGMMQCVIAVADKVFEAFLAVMADKPKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPSVTKSHLQEYLNKHQNWMSGLSQHTGLAMATESILHFAGYNRQNTTLGSPASSAQVTQLTERPACVKKDYSNFMASLNLRNRYAGEVAGMIEFSDATGRTSDLNRLMLKRLSDALDCGQPEAYTQVMFKLTALLISSKECDTQLLHHLCWAPLRMFTDHGMETAIACWDWLLAAKNGIEVPFMREMAGSWQMTVEQKIGLFSAEEKEADPLAASEQSQPRPCPPQVNPHYIWIDFIMQRFEIAKYCSSDQVEIFSSLLQRSLSLNIGGCKGSLNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVFREKIYSTAFDYFSCPPKFPTQTQKQLREDISIMIKFWTAMFSDKKYLTANQLVPPDNQDPSVNSLSVMSDVNRSNLDVTVGSRQQTAQGWINTYPLSSGMSTISKKSGLTKKTNRGTQLHKYYMKRRTLLLSLLATEIERLITWYNPLSSPELELDQTGENSVANWRSKYISLSEKQWKDNVNLAWSISPHLALQLPNRFKNTEAIGGEVTRLVRLDPGAVSDTPEAIKYLVTWHTIDADAPELSHILCWAPTDPPTGLSYFSSLYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIFLDEEGHQKDPDIGELLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPFPKGEERKKACLNSLAEVKVQPGCYLPSNPEAIVLDIDYTSGTPLQSAAKAPYLAKFKVKRCGVSELEKEGLSCRSDSIDESEEEGGDGKVCWQAAIFKVGDDCRQDMLALQIIGLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCSSRDQLGRQTDFGMYDYFTRQYGDESALAFQKARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKQRFSPNSTEREAANFILKVIQNCFLSNRSRTYDMIQYYQNDIPY
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGMALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK
The following text describes a protein:
Function:
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair. May be involved for T-DNA integration even if not absolutely required. Seems to be dispensable under normal growth conditions.
Subcellular Localization:
Nucleus.
Sequence:
MTEEIKFSVLVSLFNWIQKSKTSSQKRSKFRKFLDTYCKPSDYFVAVRLIIPSLDRERGSYGLKESVLATCLIDALGISRDAPDAVRLLNWRKGGTAKAGANAGNFSLIAAEVLQRRQGMASGGLTIKELNDLLDRLASSENRAEKTLVLSTLIQKTNAQEMKWVIRIILKDLKLGMSEKSIFQEFHPDAEDLFNVTCDLKLVCEKLRDRHQRHKRQDIEVGKAVRPQLAMRIGDVNAAWKKLHGKDVVAECKFDGDRIQIHKNGTDIHYFSRNFLDHSEYAHAMSDLIVQNILVDKCILDGEMLVWDTSLNRFAEFGSNQEIAKAAREGLDSHKQLCYVAFDVLYVGDTSVIHQSLKERHELLKKVVKPLKGRLEVLVPEGGLNVHRPSGEPSWSIVVHAAADVERFFKETVENRDEGIVLKDLESKWEPGDRSGKWMKLKPEYIRAGADLDVLIIGGYYGSGRRGGEVAQFLVALADRAEANVYPRRFMSFCRVGTGLSDDELNTVVSKLKPYFRKNEHPKKAPPSFYQVTNHSKERPDVWIDSPEKSIILSITSDIRTIRSEVFVAPYSLRFPRIDKVRYDKPWHECLDVQAFVELVNSSNGTTQKQKESESTQDNPKVNKSSKRGEKKNVSLVPSQFIQTDVSDIKGKTSIFSNMIFYFVNVPRSHSLETFHKMVVENGGKFSMNLNNSVTHCIAAESSGIKYQAAKRQRDVIHFSWVLDCCSRNKMLPLLPKYFLHLTDASRTKLQDDIDEFSDSYYWDLDLEGLKQVLSNAKQSEDSKSIDYYKKKLCPEKRWSCLLSCCVYFYPYSQTLSTEEEALLGIMAKRLMLEVLMAGGKVSNNLAHASHLVVLAMAEEPLDFTLVSKSFSEMEKRLLLKKRLHVVSSHWLEESLQREEKLCEDVYTLRPKYMEESDTEESDKSEHDTTEVASQGSAQTKEPASSKIAITSSRGRSNTRAVKRGRSSTNSLQRVQRRRGKQPSKISGDETEESDASEEKVSTRLSDIAEETDSFGEAQRNSSRGKCAKRGKSRVGQTQRVQRSRRGKKAAKIGGDESDENDELDGNNNVSADAEEGNAAGRSVENEETREPDIAKYTESQQRDNTVAVEEALQDSRNAKTEMDMKEKLQIHEDPLQAMLMKMFPIPSQKTTETSNRTTGEYRKANVSGECESSEKRKLDAETDNTSVNAGAESDVVPPLVKKKKVSYRDVAGELLKDW
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=25% cytoplasmic. 75% is associated with the cell membrane.
Sequence:
MDQEGQPLLSKDFQQVLLATASGNNSSWTERAVLNNESTDAVKHEPALGQNDVFDLDPLSFDKWVPFLRRALDKNQLDPVIDELENSIEDNFQGLELQLLQDSQMNDKLETSIDEIANIQGMVQDTLSSEISKFQIRLSESANELIVKKQMYVNNKKISLKISEATILITKVVRILELSSKCQELITERKFFKVLQNLDSLEKLYLQEFKNYNFQFLIEIYNSIPFLQKVTKDECINLIRNSLNLNLGKNLIKVGQEFVAIYENELLPQWLETRSKMKLTNFKFNSPIEISMRDESFLAKLNLGEFFQLDDFHDSIMIFQNLNELSVLSGEFNKEYELRKTKLMYPLIWKKNKTAAYQMDSLLRGTGTTPGSTAHDVSTDDPFTQSLSLHFLQDYFLKILGFLLYDINLNKATEFILVDNNYNSTNEFWDGLMDRLSPYLSYFIDEKLKTEEDMIKLKDFLCIYVAILENFKLNIEPLYKILVSIFEKFCSVSLRAFDDEFQILLNDDDFMPLSINDKTLYEKVLKICWMKEGEHLSLPDPTNGEPFAVTLPFSPLYPMTCTLAKKTYSKITAFLSIFYRHELHTLNNILVKTMDDIFNDIVNKKIRSKLESTSREEIAQILVNLDYFIIAAKEFSNFMTRENILQNPDMEIRLSSIKYLAESRKLAETKLIELIDSKISDILETIEIDWQITEVRQDPDISIIDLAQFLEMMFASTLQNLPYSVQTLLIFREFDSLTRQFMGLLLHDTPSTITHESIMNFEVDVNYLESIIPRIFPSTPGTIDSNGYQSPMTPSTPTFPNANGVDAPTLFENNIKSLEATFMELKQCIELLKTQGKDYNEPEIRLRKYSRIRQEDAALLLSKIQHFVSSVEGANGDDTSVMDSSSIFNSESASVIDSNTSRIAKFFNRR
The following text describes a protein:
Function:
Plays a role in spermiogenesis and fertilization.
Subcellular Localization:
Nucleus membrane. Note=Located throughout the subacrosomal area.
Sequence:
MENFSLLSISGPPISSSALSAFPDIMFSRATSLPDIAKTAVPTEASSPAQALPPQYQSIIVRQGIQNTALSPDCSLGDTQHGEKLRRNCTIYRPWFSPYSYFVCADKESQLEAYDFPEVQQDEGKWDNCLSEDMAENICSSSSSPENTCPREATKKSRHGLDSITSQDILMASRWHPAQQNGYKCVACCRMYPTLDFLKSHIKRGFREGFSCKVYYRKLKALWSKEQKARLGDRLSSGSCQAFNSPAEHLRQIGGEAYLCL
The following text describes a protein:
Function:
Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.
Subcellular Localization:
Mitochondrion.
Sequence:
MAPRNLLCMRSNFLFGSRCWMIQFSAEMLFKSVSFRLFGVKYGSADAEPLKNEELLHNLLTMGVDVDMAKRRQPGVFNRVGTNEQDLKMFLLSKGAKEEVIASIISRYPRAITRTHESLSKRWDLWRRIMTSDLEIVNILERSPESFFRSNNNLNLENNIKFLYSVGLTRKCLCRLLTNAPRTFSNSLDLNKQMVELLQEICLSLGHSDPTDFVRKIILKNPFILSQSTKRVKANIEFLQSTFNLNNEELLILIRGPGAEILDLSNDYARRNYTNIKEKLFSLGCTEEEVQKFVLSYPDVIFLGERKFNDKIDCLIEEKISISQIIENPRILDSSINTLKNRIKELVNAGYNLSTSSITLLSWSQKRYKAKLKKLNIG
The following text describes a protein:
Function:
Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MWLSPALLLLSFPGCLSIQGPALVRGPEQGSVTVQCRYSSRWQTNKKWWCRGASWSTCRVLIRSTGSEKETKSGRLSIRDNQKNHSFQVTMEMLRQNDTDTYWCGIEKFGTDRGTRVKVNVYSVGKDTMSTSNQLPWPTVDGSTDMVSSDLQKRTYYMLLVFVKVPALLILVGAVLWLKRSTQKVPEEQWRHTLCSDLDSELLAKDISP
The following text describes a protein:
Function:
Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MNVDAEASMAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRLLEMEFEERKRAAEQRQKAENFWTGDTSSDQLVLGKKDMGWPFQADGQEGPLGWMLGNLWNTGLFCLFLVFELLRQNMQHEPAFDSSSEEEEEEVRVVPVTSYNWLTDFPSQEALDSFYKHYVQNAIRDLPCTCEFVESFVDDLIEACRVLSRQEAHPQLEDCLGIGAAFEKWGTLHETQKFDILVPIVPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLCLVHHHRDPSAVLGKCSSSIKAALCTGFHLDVCKTVQWFRNMMGNAWALVAHKYDFKLSLPPSTTSCKLRLDYRSGRFLSIHLVLGVQREDTLVYLVSQAPDQEQLTSVDWPESFVACEHLFLKLVGRFAPENTCHLKCLQIILSLRQHQSLPHGASRPILTSYHFKTALMHLLLRLPLTDWAHNMLSQRLQDILWFLGRGLQQRSLHHFLIGNNFLPLTIPIPKTFRNAEPVNLFQHLVLNPKAHSQAVEEFQNLLTQVKTLPHAPLAAAP
The following text describes a protein:
Function:
May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed.
Subcellular Localization:
Cell surface.
Sequence:
MLFLRFFIFTFFTSIFTVVVSEPPVSAKFAKRVLSATSSSSSTCPEFITIFSEGPSEYITTIYPSSKSSGRGTTNHSTIYTTINSGTVASTYTVTLADGDVVVKDIEPTAGTVTTTITSGSHEFTTTLAEASGTVPGTVEVVEPLAGTVTTTIHSGSVEYNTTLATASGTVPGTVEVVEPAVGTVTTTIYSGSEEFTTTLASASGSISGTVEVIEPTAGTVTTTIYSGDQEYTTILAEASGTVPGTVEVIEPAVGTVTTTTYSGSVEYTTTLVPASGSVSGTVEVVEPAVGTVTTTLQSGSQAFTTTVPASGSVSGTVEVVQPTGGTVTNTVYEGSQTITSTLATASGTVPGTVEVILPGPSTIYSGTVATTITYDVSSTPASTVVVIPTAVCNGERGLQYAVYNYDISSSKNQFCATSGVTDVSSFTQPAYFGSSDLDQSSPLFTGVLSSSDSVPQWTSSYNLPGYPPDATAMGSTSSACKVIVYQFFFRVPVTDTFSLDVTNVDDVFYGWFGDKAISGWSNTNYDTYAYWHATNGQTGIASFSMGSLTADTYVPVRFVVANGAGKGGFDFSFVDSEGNSYNPTSYAYTATCTESFLPFGQGNGGVDN
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
Miscellaneous:
MISCELLANEOUS: Some strains of E.coli, such as ATCC 25922, can metabolize carnitine under aerobiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKVRETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMSKGKDPYYAGCGLYKCADGYIVMELVGITQIEECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLATHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKGPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
The following text describes a protein:
Function:
Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Exhibits cyclobutane dimer nonmutagenic bypass activity in vitro.
Subcellular Localization:
Nucleus. Note=Accumulates at replication forks after DNA damage.
Domain:
The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
Sequence:
MPVARPEASDARVIAHVDMDCFYVQVEQRKQPELRGLPSAVVQYNEWQGGGLIAVSYEARKCGVKRSMRGDEAKAACPQIQLVQVPVARGKADLNLYRSAGSEVVSILAKSGKCERASIDEVYLDLTDAAESMLADAPPESLELIDEEVLKSHILGMNREDGDDFKESVRNWICREDADRRDKLLSCGIIIVAELRKQVLKETEFTCSAGIAHNKMLAKLASGMNKPAQQTVVPYAAVQELLSSLPIKKMKQLGGKLGTSLQTDLGVDTVGDLLQFSETKLQEHYGVNTGTWLWNIARGISGEEVQGRLLPKSHGSGKTFPGPRALKSLSTVQHWLNQLSEELSERLGSDLEQNKRIASTLTLHASAFRSKDSDSHKKFPSKSCPMRYGVTKIQEDAFNLFQAALREYMGSFGIKPQGNKLETWRITGLSVSASKIVDIPSGTSSIMRYFQSQPTVPSRSADGCVQGNVAMTASASEGCSEQRSTETQAAMPEVDTGVTYTLPNFENQDKDIDLVSEKDVVSCPSNEATDVSTQSESNKGTQTKKIGRKMNNSKEKNRGMPSIVDIFKNYNATPPSKQETQEDSTVSSASKRAKLSSSSHNSQVNQEVEESRETDWGYKTDEIDQSVFDELPVEIQRELRSFLRTNKQFNTGKSKGDGSTSSIAHYFPPLNR
The following text describes a protein:
Function:
NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MVPGKFIFTATFVLLCTIIAVVLEYQSKKDKPVLDKEKLQEFPLVAKTVLTHNTAIYRFGLPKSTQVLGLPIGQHISVQANINGKDILRSYTPTSLDSDAVGHFELLIKSYEKGNISKHFAQLNIGDKIKVRGPKGFYHYQPNMNEEIGMIAGGTGIAPMYQIMKSIFANDSDKTKVSLVYGNQTEEDILLKKELDAFVERKPDQFKVYYLLDKAPEAWTGGVGYITVDTMKERLPAPAEGVQLLVCGPPPMVSSIKRNAVTLGYEKAKPISKMGDQIFVF
The following text describes a protein:
Function:
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
Subcellular Localization:
Cytoplasm.
Domain:
A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
Sequence:
MIALIQRVTRASVTVEDEVTGKIGPGLLVLLGVEKEDDEQKANRLCERVLGYRIFSDADGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSGGAAPDRAQALYEYFVERCRQQAINTQTGRFAADMQVELVNDGPVTFWLQV