lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Glutamate-gated chloride channel subunit. Together with Gamma-aminobutyric acid receptor Rdl, plays an important role in the visual response by regulating the activity of ON/OFF-selective neurons.
Miscellaneous:
MISCELLANEOUS: Channels desensitize rapidly in the continued presence of glutamate and are activated by the glutamate analog ibotenate. In Xenopus oocytes, avermectins and nodulisporic acid directly activate channel conductance.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MGSGHYFWAILYFASLCSASLANNAKINFREKEKKVLDQILGAGKYDARIRPSGINGTDGPAIVRINLFVRSIMTISDIKMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKESMKKKRRDLEQASLDAASDLLDTDSNATFAMKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRQCSRSKRIDVISRITFPLVFALFNLVYWSTYLFREEEDE
The following text describes a protein:
Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MPRSKRARIVHESKVTKKSHKEQTRRLYANIRECVEKYDHLFVFSVDNMRNTYLKDVRTEFADSRLFFGKTKVMAVALGHNPENEAAPNLHKLSPYLTGAVGLLFTSRDPESVLSYFDAFRPLDFARAGTVSTRSFSIPNGLVYSRGGEIPASEDEPVSHTIEPELRKLGVPTRLVKGKVMLELTDGQEGYPVCKEGEVLDSRQTTLLKMFGVATAEFKVDLKAQWTRSTGEVKILEKDEGMDVDGQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. The adapter phyl is required to direct the degradation of the two isoforms of the transcriptional repressor Tramtrack (Ttk). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. A phyl-independent mechanism of degradation exists for isoform beta of ttk that involves motifs in the C-terminus of ttk.
Domain:
The RING-type zinc finger domain is essential for ubiquitin ligase activity; The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.
Sequence:
MSVRNSRPQLSWPERVSPQRTIDTPTASGEMLTRRQSAPALVVPPEETTHVVVVKRQSPDAAAAGELVPSRRKDSVAVQSGIVATGPLDTTRSGARDDFLMALLECPVCFGYIMPPIMQCPRGHLICSTCRSKLTICPVCRVFMTNIRSLAMEKVASKLIFPCKHSHFGCRARLSYAEKTKHEEDCECRPYFCPYPDDKCSWQGPLRDVYQHLMSSHENVITMEGNDIIFLATNVNLEGALDWTMVQSCHGRHFLLSLEKINLGEDCQQYFTACRMIGSMKDAAEFVYNISLEAYNRTLRWQSKPRSIRENFSSFTNADFLVLNKHTVELFSEDGNLALNVVIRKVEERTN
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MTWNWRTTLGAVLLAAAIISGWSAWQQRARPVAAAVDDSKADYVLRDFELIALDKESGKESMTLRAPEMHRNRADQTSEITTPVFLLPDNANNPWTLRSKTGWISPKGDEMRLRGDVSGDSPTTGNTPPTTFRTESLDVFPQQNLAKTAAPVTMRRPGIMQSGVGFEADLKTRQYKLLSQVKTRYEPNAAR
The following text describes a protein:
Function:
In the food vacuole, acts downstream of proteases plasmepsins PMI and PMII and falcipains during the catabolism of host hemoglobin by cleaving peptide fragments of alpha and beta hemoglobin subunits generated by PMI and PMII and falcipains. In the apicoplast, degrades apicoplast transit peptides after their cleavage. Prefers bulky hydrophobic amino acids in the P1' position at both acidic and neutral pH (By similarity). At P2', prefers hydrophobic residues at acidic pH; at neutral pH, these same residues are abundant but prefers Arg (By similarity). At P3', prefers hydrophobic residues, especially Met, at both pH conditions. At P4' and P5', prefers acidic residues at acidic pH, however, at neutral pH, the enzyme is less selective at these positions (By similarity). The optimal site cleavage at acidic pH is YNEHS-|-FFMEE and, at neutral pH, MKRHS-|-FRMRG (By similarity).
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein. Plastid, apicoplast. Vesicle. Note=Localizes to the food (or digestive) vacuole, an acidic vacuole where host hemoglobin is digested. During the trophozoite and early to mid-schizont stages, localizes to the apicoplast.
Sequence:
MNLTKLMKVIGYINIITNCVQSFTNRADKKRYNVFAKSFINTINTNLYTFKAVMSKTPEWIHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPLDVEQAFAFYVKTLTHSGKGIPHILEHSVLSGSKNYNYKNSIGLLEKGTLHTHLNAYTFNDRTVYMAGSMNNKDFFNIMGVYMDSVFQPNVLENKYIFETEGWTYEVEKLKEDEKGKAEIPQMKDYKVSFNGIVYNEMKGALSSPLEDLYHEEMKYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKKVKVFFFSKNNPTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDHSEEKENLVSVAWLLNPKVDKTNNHNNNHSNNQSSENNGYSNGSHSSDLSLENPTDYFVLLIINNLLIHTPESVLYKALTDCGLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHYEVEDVIMNALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSKLNYNRDPLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILLEGDENYAQEQENLEKQELKKRIENFNEQEKEQVIKNFEELSKYKNAEESPEHLNKFPIISISDLNKKTLEVPVNVYFTNINENNNIMETYNKLKTNEHMLKDNMDVFLKKYVLKNDKHNTNNNNNNNNNMDYSFTETKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTVDELAYLNLFKTLILENKTNKRSSEDFVILREKNIGSMSANVALYSKDDHLNVTDKYNAQALFNLEMHVLSHKCNDALNIALEAVKESDFSNKKKVIDILKRKINGMKTTFSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQEQLELAENDFKTLENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKNLVSYFEENDKYINDMQNKVNDPTVMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGILFKPGEYLDPSFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFLSARDPNLEKTLATFRESAKGLRKMADTMTENDLLRYIINTIGTIDKPRRGIELSKLSFLRLISNESEQDRVEFRKRIMNTKKEDFYKFADLLESKVNEFEKNIVIITTKEKANEYIANVDGEFKKVLIE
The following text describes a protein:
Function:
Probable dual specificity phosphatase that binds and dephosphorylates MPK18, modulating the organization and dynamics of cortical microtubules. Acts as a negative regulator of abscisic acid (ABA) signaling during seed germination and light-induced stomata aperture.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEPEKKRDQPFSQEKDEEKDLYLVHDEHESPLPLTVTSRVLYMLGDIASGPAYRFTQWLDLVRKRSATYGSSGFPHRLHRIDDMVTSAGERNTDPKSPPSRQSSEISLWERLGKASTVDIDSSCFSWNMLSSLHHTEHSSSTDHSEEDQSKPLEVTVNSGGVVFFALFNSSSSEDASRKEEAAVIKFASSRMATQSERLGYEFSKWLGVQIPQARVIHSCNPEWTLIKEATEKAQAKATSEGDEVGEMTCSELLEALELSRCLLLMSYVHGCPMLESMSSFETEEKAERAAAALGRILVLDLVIRNEDRLPCRQLRWRGNPANLLLTDRIVSSAKHHECSFDEAFDSAIKRYHPKDYRSIQRERRASSVDSRSRLSISDQMLVSQASDFSDITESPRSYDTGLMSPMSDRSVAADFHLVAIDSGVPRRPPAGKRASDQEIYPRLVELLLNSSQYSSNLLHEITEGSLGYPQAEDGEETSNVRSVVTPVVREFRNGFRAGLRDLQEFHIFLVTLHQKLDVLLRAFFSMMDKTMCADFDREDFAVPESPSHTHGHEVNHYPSPSKDRVPSDNSSDHSESDMQKSVPRTPNSENKEDGSSPKSRESWHGRSGKGGESLSSQRLAAKLRDFHKFAKVDAESNKELDQWNETLRNEVMKLCQENGFNTGFFEGSDNNSCTDAYELKVRLEHILERISLISKAANTEKPSMIQENLFIGGGLAARSIYTLQHLGITHVLCLCANEIGQSDTQYPDLFEYQNFSITDDEDSNIESIFQEALDFIKHGEETGGKILVHCFEGRSRSATVVLAYLMLQKKLTLLEAWSKLRKVHRRAQPNDGFARILINLDKKCHGKVSMEWRQRKPTMKVCPVCGKNAGLSSSSLKLHLQKSHRKLSSGSVDSAMNMEIQKALEALKLSTGRGSSASSNSFQSHPG
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
Subcellular Localization:
Cytoplasm.
Sequence:
MEINEKNKKKEQQALIIRKYQQYLKLEKSLSPNTLDAYLTDLDKLMSFLTLEGIDVLEVCLSDLQRFAAGLHDIGIHPRSQARILSGIKSFFRFLIMADYLEADPSELLEGPKIGLKLPEVLTVEEIDNIISSVDRSKAEGQRNRAILETLYSCGLRVSELVSLKLSDLYFDEGFIKVEGKGSKQRLVPISPRAINEIKLYFLDRNRIEVKKDYEDFVFVSQRRGKSLSRIMIFHMIKELAQNAGITKNISPHTFRHSFATHLLEGGANLRAIQCMLGHESIATTEIYTHIDRNMLRSEIIEHHPRNIKYRREKESGFH
The following text describes a protein:
Function:
Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys); In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.
Subcellular Localization:
Mitochondrion.
Domain:
'KIIK' region and 'KMSKS' region are required for cysteine persulfide synthase activity.
Sequence:
MLKLISRNAINKNKIILFRLYTTTINSSNNGSTIREWKKPSLENSYDTGIMVKNSLFKNGNVPFLISNCSEKNQRPISWYTCGPTVYSSSHIGHARNYMTVDIIQRILINYFRFNIIHVMGLTDIDDKIINKSKQELISASELSKKFEQEFFEDLKSLNIKPPMFTTRVSEHIDEIIKYIEKIKENQLTYESTKSVIFDVNKFGIDRYCSLRAANQQIKSDDTLLEKDKKSSQDFVLWKAYNENIDIDGTGNPVCWDSPFGKGRPGWHIECSAMIDSIFKDHLDVHSGGVDLEFPHHQNEIAQCEGHSHSHGSGDAESTQWANYFFHIGHLILNNEKMSKSLGNVITIRDFLSRYSANSLRWICLIHKYNDPLSFSDETLQLCISKEIKFLNWFKIVRSKLKLEQTSVNKVKKTFNHSIELLNQLSETKYLIEKDLKDDFNTPSVIKRLELLMKQTNESMNSIDTDLLFNVQDYVESILNIFGLEVNSEISDHNKTDESNQFLLEKLLDFRSDVKNLAKNEKSLDQIKSKIYQITDQLRSDCQSEISLRVSDIPDKGTNKPYTVDWLDKNHIQLLNIKKQSKK
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MVYKLNLFIVLFFHLIIQANAFTGRRDGDSEDEEEYDGNDENGEEDEDEDGDEEREEGGDSDYSGGDLNNDFDDTQHGNEDLDDDVDGGRNDEEGEGVDDDIDEDYEDEDVDEDMEEDEEEEDEEEEDGESDDGTDQSNDNDSHKNEPCVLERQEVERQIILRKSNNSKKSDKKQQTNANYNDDEEDGDDDEDGEELRLPECTALGEFKLKQCSKRHCWCVNKQGVKLEGSRRSGELPLSCESFDPERDAIHEMEHPKNLASMNGNHHSSGPAFLAVVAILVITGLLGSALLGIFVVYRMRKKDEGSYALANSSNNAPERRSTRSLIFNNANNNNNSGSSTGCGVVGGFVGVVSGGGNKDQDQHFGYNIQQPLQQMQQQQEFYA
The following text describes a protein:
Function:
Potential transporter for phosphate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEIKNIKEFEKASKKLQKDTLKIALALLFLIGAALLALIFGQANSKGLLLIFAAVIGGYMAMNIGANDVSNNVGPAVGSKAISMGGAILIAAICEMLGAIIAGGEVVSTIKGRIVSPEFINDAHIFINVMLASLLSGALWLHVATLIGAPVSTSHSVVGGIMGAGMAAAGMVAVNWHFLSGIVASWVISPLMGALIAMFFLMLIKKTIAYKEDKKSAALKVVPYLVALMSLTFSWYLIVKVLKRLYALNFEIQLACGCILALLIFILFKRFVLKKAPQLENSHESINELFNVPLIFAAALLSFAHGANDVANAIGPLAAISQTLEDANSPIGNTLSSVPLWIMVVGAAGIALGLSLYGPKLIKTVGSEITELDKMQAFCIALSAVITVLLASQLGLPVSSTHIVVGAVFGVGFLRERLREQSRRRFARIRDNIVAAHFGEDLEEIEGFLERFDKANLKEKSLMLESLKKSKNTAIALELKKKEKKSLKKVYKEEVIKRSILKKIVTAWLVTVPVSALLGALLFVALGFIEKYF
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MGEWAFLGSLLDAVQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQPGCRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGKEAGGAEAAAQCAPGLPEAQCAPCALRARRARRCYLLSVALRLLAELTFLGGQALLYGFRVAPHFACAGPPCPHTVDCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKGRPRAGERDNRCNRAHEEAQKLLPPPPPPPPPALPSRRPGPEPCAPPAYAHPAPASLREGGSGRGKASPATGRRDLAI
The following text describes a protein:
Function:
Might contribute to the loading of the ESCRT machinery.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MVNAMVERATSEMLIGPDWAMNLEICDMLNSDPAQAKDVVKGIKKRIGSRNPKAQLLALTLLETIVKNCGDMVHMHVAEKGVIHEMVRIVKKKPDFHVKEKILVLIDTWQEAFGGPRARYPQYYAGYQELLRAGAVFPQRSERSAPVFTPPQTQPLTSYPPNLRNAGPGNDVPEPSAEPEFPTLSLSEIQNAKGIMDVLAEMLSALEPGNKEDLKQEVMVDLVEQCRTYKQRVVHLVNSTSDESLLCQGLALNDDLQRVLTNYEAIASGLPGTSSQIEKPKSETGKSLVDVDGPLIDTGDSSNQANGATSSSGNGVLNQLALPAPPVTNGSANSKIDLLSGDDLALVPVGPPQPASPVASDQNALALIDMFSDNTNNPSPATAPSGNPAQNIPLNPQGHQQPNSQAGEAGLQQSNGFAPQVGYSQFEQPSYGQGVSSPWSSQPAQQPVQPSYGAQDSTAFPPPPWEAQLQDYSPSAESGSPFSPGMHPTQTAFTHAQPVNNNNPYPQIPQTGPPVNNNSPYAQMPQTGQAVANISPYPQIPQNGVYMPNQPNQALGSGYQPQQQQQQQMMMAQYYAQQQQLQQQQQQQAYGNQMGGYGYGYNQQQQGSSPYLDQQMYGLSMRDQTSHQVASSSSTTSYLPPMKPKNKPEDKLFGDLVDISKFKPTKPTSGRAGTM
The following text describes a protein:
Function:
Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSRLSPVNQARWARFRHNRRGYWSLWIFLVLFGLSLCSELIANDKPLLVRYDGSWYFPLLKNYSESDFGGPLASQADYQDPWLKQRLENNGWVLWAPIRFGATSINFATNKPFPSPPSRQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIILLSSVVQPNFWWLLAITVLFGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPFILCSSITTLTSLDFLGFGLPLGSPSLGELLLQGKNNLQAPWLGITAFLSVAILLSLLIFIGEAVRDAFDPNKAV
The following text describes a protein:
Function:
Involved in cellular morphogenesis and cell wall integrity. Important for the maintenance of a cylindrical cell shape.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Localizes to cell tips during interphase and to the medial ring during mitosis and cytokinesis.
Sequence:
MMVIENPFLSTATSSQTPQEDGVYTSSLHNSNNPFLAPKTERVADPVMESMADDLFNSIQKKKEPSPASSASASPVKKSAEALAERSNSSMGTFDPPPRYSKIARARSTHVASSSRHRSPSHNDSSPSTQSSLKSRGSIRRYKSVREGSHRPGRSSKEPLDQIDRLDVTGLYGSGSFHHDGPFDACRPHRNRNSKKAPVAAFPKDSIANSIPKVGETYNDPSVPKDFSRKAIHESLRTKNILQSPYKSVGIEEEFPSSGNNDTPGLTDSTRIEGAMASKNAIARNEEMLAMEKAGLGRKNSLIRKLGLNRSASMMSRTPNTLNRPSNYRSHSSMGTRRSPLNSPSQLDPISNENESDTDDSNTGLRNRTSPTAAPPPPSRRKTGGLNTRPYPQHAESQMSLPLTAKERSKPKKMGFFRRLFHKKS
The following text describes a protein:
Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Sequence:
TIFEILKKMDNNDEFKRRICNEAETLVKDFLPRKITEYDSLLQENDFNLVNIFEVKSSTIESLKDLDQSKENTLESGETNSSSKPERVFATNEYITRLVDRLKPEIITLLEAVGTLRMWVILLIPKIEDGNNFGVEVQEETLGELKTVEQELASNQEQIAGYFLSRAKVISQLCKRPGVQDYKRFVEEEDEKQFVSMRLMVAELRNACSSLHDLINKNIDKIKTPRNRNTMSSIY
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKSRKAYKKLMRSFEQLGFRQPYQLLLTSDIVLDTVKLDIMNLFQKTLNTKDIKPMITQCCIRALYAKNKPGPDRDPNVPAAIERAKTFERRRCGHLMDQDPLTERECMLSVVDPKGKGQNKFRYVVATNDEWLRHRLRSVVSTPLMYCRRSVMILEPMSEASQQIRDREERQKFKDGIIRRSLKRKREDGDEKEDSEGDSDSEGEGGQGQEVNKEKSTDAAGSAEQEQKEKKKKKKNYGPKQPNPLAMKKAKKEDDKKKKSPSDPQRPKKPSETTTDSTAEGKAKRKRRRKTAGGAAEGGGGAGEQSAETTVAGVKEE
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. In yeast, it is involved in the retention of proteins in an intracellular membrane compartment, presumably the trans-Golgi. The yeast light chain is important for cell growth. The light chain may help to properly orient the assembly/ disassembly of the clathrin coats.
Miscellaneous:
MISCELLANEOUS: CLC1 binds calcium, and calmodulin in presence of calcium; MISCELLANEOUS: Present with 3490 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MSEKFPPLEDQNIDFTPNDKKDDDTDFLKREAEILGDEFKTEQDDILETEASPAKDDDEIRDFEEQFPDINSANGAVSSDQNGSATVSSGNDNGEADDDFSTFEGANQSTESVKEDRSEVVDQWKQRRAVEIHEKDLKDEELKKELQDEAIKHIDDFYDSYNKKKEQQLEDAAKEAEAFLKKRDEFFGQDNTTWDRALQLINQDDADIIGGRDRSKLKEILLRLKGNAKAPGA
The following text describes a protein:
Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MHKGPEFNPQRGLKRRKGGRFIWGGGTFRGSNSEASNAYISKTWRKTSFRAKVCKHQALLTSQASPTWGRCCGPSHTCALGPTAPCPASLPAPSWRPRGWLHANCEHGCKNPGAPCWGAGMIGQKTLYSFFSPTPTGKRTTRSPQPAPGSGVTAENSSDAAASPAKKARVEQDEPATPPSSPLSAEQLVRIQRNKAAALLRLAARNVPAGLGESWKQQLCGEFGKPYFVKLMGFVAEERKHHKVYPPPEQVFTWTQMCDIRDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIFKELSTDIDGFVHPGHGDLSGWARQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNLNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKANELLQRSGKKPISWKEL
The following text describes a protein:
Function:
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Subcellular Localization:
Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
Sequence:
MGSQPPLGSPLSREEGEAPPPAPASEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQLPSPRTSLMSVCLGRDCDMS
The following text describes a protein:
Function:
Acts as a transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MSSPSSSRRQWCYLCDLPKMPWTVVWDFSEVVCRGCVNYEGANQIEFLIASARQLKRSHSMQDGSVRSPGPSLNKQGAPARGEAGADGARTHNERFERGGRAESGGSTARVPPNGLHRDGQPAQEVNRQSPSLSRRPMLGAAIPPSLVTQSIAGIPHGLFAGVPAGLTARTAPMSSPMIFPAPVLAEMSRRQQLGMGMGIPPFMTQELERELNSSQSKTQAHTTATVTGSSSSKTLPSSSFSMAGGVSQTSPKPASSPARQPRPPTARSGGEPLGSSTSAEATTTAAALPNSGASEQGGASASSTLSGGNTLSCTLCHERLEDTHFVQCPSVPGHRFCFPCTRVYIQSRRGDGEVYCPSGERCPLDNSPNSPPWAFMQGEVSTILGAGAAPAAAGQAAAAGSGPAAPSVNADVAVKKERET
The following text describes a protein:
Function:
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSSLLNISHCSYHGYSGLTSRGGINTVENHRWVWHNNGVRLSFPRAESSINITMGCTLQRGIAKSLSQENLVELSDENDDLCPVECVTEFKTDDELLSVLEKSKETNSLVVVDFYRTACGSCKYIEQGFSKLCKQSGDQEAPVIFLKHNVVDEYDEQSEVAERLRIKAVPLFHFYKNGVLLESFATRDKERIDAAILKYTSSES
The following text describes a protein:
Function:
Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules.
Sequence:
MMAEQVKCASAGVSSGAGSGPVVNAELEVKKLQELVRKLEKQNEQLRSRAASAAAAPHLLLLPPPPPAAPPPAGLQPLGPRSPPAATATAAASGGLGPAFPGTFCLPSPAPSLLCSLAQPPEAPFVYFKPAAGFFGAGGGGPEPGGAGTPPGAAAAPPSPPPTLLDEVELLDLESVAAWRDEDDYTWLYIGSSKTFTSSEKSLTPLQWCRHVLDNPTPEMEAARRSLCFRLEQGYTSRGSPLSPQSSIDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASVSRHSSSVSLSSGKKGTCSDQEYDQYSLEDEEEFDHLPPPQPRLPRCSPFQRGIPHSQTFSSIRECRRSPSSQYFPSNNYQQQQYYSPQAQTPDQQPNRTNGDKLRRSMPNLARMPSTTAISSNISSPVTVRNSQSFDSSLHGAGNGISRIQSCIPSPGQLQHRVHSVGHFPVSIRQPLKATAYVSPTVQGSSNMPLSNGLQLYSNTGIPTPNKAAASGIMGRSALPRPSLAINGSNLPRSKIAQPVRSFLQPPKPLSSLSTLRDGNWRDGCY
The following text describes a protein:
Function:
Transcription factor that regulates morphogenetic cell movement during development.
Sequence:
MENKFLSGSSELFSSLYNNTNTNSNNNNNNNNNNNNNNNINNTTTTTTTTTSNNNLKNNFSNKNNFSFNNSSNSLSSSFGVPSSPPPQKLNNSGYNFNSSSYSSLVPNIKKRSNSLDDNMSVPTLQNFTNNNNNNNNNNNNNNNNNSNNNSSNNNNNNNNNNNFNNSPTSSPTPYVPTTPLINSYPSSPFLINQQPLSSSTPFPFNHQPYHIHPFTTLSLNNSNGINNNNHNNNHNNSNNNNNNNSNSNSNNHNNHNNNNQSIVPQSIHLQSTTPQIQPLSLQPPQQLPTINGPTSTPPSSSNSTTTTTTTTTTPSTNENSNNNNNSYNTNNNNKPEIQLIDSGAILECFIELRDLGSSISKQSKESMVSGDFANGLERIKVTLSTLTNKIETLDLSIQNIIQNEPRSRIFGNSSDESRVPVLTRPRRFRKSKVKSKENNHHNNNNNNINNININNNNCSTPLLQSPQLSSSSPSLNSSHDGDQHLSSPQLSSSTPQHKSNGNGNTNSTNNNKRKIGELKQCTSCGTTSSPEWRKGPAGNQSLCNACGLYFAKLVRREASLTWKPQSVVSVNDLLCAGKDQKQSNTTSQLTTFINSVEHNQQIFQQQQQQQQQQQQQQQQQQQQQQQQQNHHHQQLQQQQQQQQQQQLHH
The following text describes a protein:
Function:
Displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase; [Isoform A]: Shows histone acetyltransferase activity toward free histones; [Isoform B]: Does not show histone acetyltransferase activity toward free histones.
Sequence:
MAQFTLYNKHSAPPSSESTRVDCEHVPLCSINDVQLRFLVPDDLTEVRQLCQEWFPIDYPLSWYEDITSSTRFFALAAVYNLAIIGLIVAEIKPYRNVNKEVIANMSDSDELYTRLSGFPMQDKGILPDSMGRSADVGYILSLGVHRSHRRNGIGSLLLDALMNHLTTAERHSVKAIFLHTLTTNQPAIFFYEKRRFTLHSFLPYYYNIRGKGKDGFTYVNYINGGHPPWTLLDHIKHYASMVRHTSSLCAWLAGRVQQVVRWFYHKLLTRFNFIE
The following text describes a protein:
Function:
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Subcellular Localization:
Endomembrane system.
Sequence:
MENAFAPISEACVKALSDKTYDKRKVAALEIEKMVTDFKMKKNMTQIKRIIDVLSRDFVRSNDANKKKGGLIALAATSIALGKDTEKFIEDIVNPIMNCLIDNDNRVRFFASESLYNVVKVARGAVLPFFPSVFNALSRLVTDPDQTIKNGSEILDRLLKDIVIESSQTFDLDAFIPLVRERIMVKSSFARQFIISWISVLNAVPEINMVVFLPEILHGLFQILEDPLPEIQRMCESLLAQFLKIIKLDPSAADIPTMTNVLIVQAQSSNPLIQFYAITWIKEFVQLSGGEILCFASGIFTAILPCLAFESDAKKNIKDCANAVNLHLLELISSGEDKQKNLSYLDLNSVMEVLRQYLVHSPVPTKIAVLKWVHHLFTEVHDEMSEHANKLFPVLLRDCLSDSSDEVVLQAIVVLAEIVNSATVKGNDFDQTQYRQFLVELLNLFSENNTFLEKRGTLIIRQLCRLLNAEYIYRTFAEILLEERINLKIASTMVRTLNMILLTTSDLFDLRNMLHDIRNEKSASLFECLYKCWAHCPVSTLSLCLLAQCYQHVSEIVTLFADIEITVDFLVEIDKMVQLIESPIFASLRLALISHSNDNADAQHLSRALYGILMLLPQTEAFHLLNNRLKCVPNYWSQPNKISSKSTNESQCNIKFDELFTYFKYVQDLHHQKRVEKRKKNQF
The following text describes a protein:
Function:
Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMTDRALGTLLLACNSSFFIYYVLWIGVMPFVDESHFTQALFLPREYGLLLAALIMTTAIGVGMFVGSLHTIWRTGYVPPSSSRTSMGTEATLLASEATTDRVAPDVAMAAK
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
Subcellular Localization:
Nucleus.
Sequence:
MDLISESDLNTCLKTLESSSQGAADGDKAEEARMLDVLKQLQRRGVTADLLKRTNAGKRLNKFCKHASDAVSKSAKAAVEAWKQCVKKETADGGDTAEGGASQPAKAPMANDSAAGGREGQPLAGASAAPASGTSGGGLRSAGSSQQLLTRQPSASSSGFSVDPPRCGNETRDKVRSMLAEALAVGYVGGGDTGPSSLQSPNQLGAAIEEALYDLMGGGGGGGGGREAVSAEYKAKARSLCFNLKDAKNPDLRERVLSGSVPPETLVRLSAEEMASDEQKKKNRELKEWLAKEAVRGATTNAATTDMFQCGRCKQRKCTYYQLQTRSADEPMTTFVTCTNCGQRWKFC