lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases. Also required for silencing of the DUX4 locus in somatic cells.
Subcellular Localization:
Chromosome. Nucleus matrix. Note=Localizes to Barr body; recruited by SMCHD1.
Domain:
The Pro-Xaa-Val-Xaa-Leu (PxVxL) motif mediates interaction with HP1 (CBX1/HP1-beta, CBX3/HP1-gamma and CBX5/HP1-alpha).
Sequence:
MSNNLRRVFLKPAEENSGNASRCVSGCMYQVVQTIGSDGKNLLQLLPIPKSSGNLIPLVQSSVMSDALKGNTGKPVQVTFQTQISSSSTSASVQLPIFQPASSSNYFLTRTVDTSEKGRVTSVGTGNFSSSVSKVQSHGVKIDGLTMQTFAVPPSTQKDSSFIVVNTQSLPVTVKSPVLPSGHHLQIPAHAEVKSVPASSLPPSVQQKILATATTSTSGMVEASQMPTVIYVSPVNTVKNVVTKNFQNIYPKPVTEIAKPVILNTTQIPKNVATETQLKGGQHSQAAPVKWIFQDNLQPFTPSLVPVKSSNNVASKILKTFVDRKNLGDNTINMPPLSTIDPSGTRSKNMPIKDNALVMFNGKVYLLAKKGTDVLPSQIDQQNSVSPDTPVRKDTLQTVSSSPVTEISREVVNIVLAKSKSSQMETKSLSNTQLASMANLRAEKNKVEKPSPSTTNPHMNQSSNYLKQSKTLFTNPIFPVGFSTGHNAPRKVTAVIYARKGSVLQSIEKISSSVDATTVTSQQCVFRDQEPKIHNEMASTSDKGAQGRNDKKDSQGRSNKALHLKSDAEFKKIFGLTKDLRVCLTRIPDHLTSGEGFDSFSSLVKSGTYKETEFMVKEGERKQQNFDKKRKAKTNKKMDHIKKRKTENAYNAIINGEANVTGSQLLSSILPTSDVSQHNILTSHSKTRQEKRTEMEYYTHEKQEKGTLNSNAAYEQSHFFNKNYTEDIFPVTPPELEETIRDEKIRRLKQVLREKEAALEEMRKKMHQK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MKMMECFEAYGLERGKRECADLISDFQECVGMQKQLMRFHAMRNERYKQWLKGERKGQEFFADPPRVDAY
The following text describes a protein:
Function:
Involved in trafficking and recycling of synaptic vesicles.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Early endosome. Golgi apparatus, trans-Golgi network. Late endosome. Membrane; Multi-pass membrane protein. Recycling endosome.
Sequence:
MEPTNSESRHRLNGGGRSSAPAGSGEYIKVVESQCETDGFVNEQWTEPAMPGPVPWKTIIIILLLFIGGIVCIAFATLNWVTDTSRERSDRVWALGIIGALTFIPGSYYVYVLFCIMLNRNGFTMDEIRRLG
The following text describes a protein:
Function:
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein.
Sequence:
MAQCTPVAKCLQGTESALLQALMEDMYIKAPGNPFPQESKLRLVGGSGRFSGRVEVLHQGAWGTVCDDLWDLNEAEVVCWPLGCGRAVSALGKAHFGLGSGDILLDNIQCSGSESHLGQCPSSGWSDHNCGHHEDAGDRVSSPASLFPGALGASLRLGNGSHRCEGRVEVFYSGTWGTLGCGEALSAPAQSYFDRGTGHITLDDVKCTGNETKLWQCPHNGWFSHNCGHHEDASVICSDVALRLANGSHPCEGRVELHFNGSWGTVCDDGWDLRDAEVVCRQLACGGAVAAPERARFGRGLGPIALDDVDCVGTEARLWQCLHGGWFSHNCGHHEDASVVCSGGPDSEAGRAK
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGGNDSVLHRPVEAPLMEDGELSAVFTIRNSSGIHVRPAGTIVKLFEGEECEATLTYLGKTVNARSVMSILMLGASYNGEVAVHIKGPSASRVMQKLSEVFNSGFGEL
The following text describes a protein:
Function:
Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Also has a role in cold adaptation, perhaps through effects on sterol biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MEDSRLLITLILVFGVIFLKKFFQSNQHPSAQRLSATGVNAHGRPQGSTQNALRRTGRVNGGHPVTTQMVETVQNLAPNLHPEQIRYSLENTGSVEETVERYLRGDEFSFPPGFEPSRAPMGANAAVDNNAAGGGEFNDPRKKNMICAENLLDKFHVDLNEDMSNLSFKDLDIEERKRLLVWQARKNLETKLQSDKDLQSLLT
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MASWFPSILTGQTQDRPQVPPIPPITALQQQRQKQIDSLFQYNYNVTETVKSQEFRIVASSTNNATYYLNINLPPQFPDEKPILSVYPSCRHPWINEQMIVTGCPAINGFMVHSCLGLAVQQVVKEFQERPPQLYQQTHQSQRNYNSYPSPPSIPDNNMNMPRAINVNDGDVPYNPPMLFKNNTYNKPEVQTKFPKLRSYSTSELKELRGNHEAIEKFIQNLDEVHMIKEDREQILNRCEDIARMNLAKAPELENRRQSLLELYITREEYQKGLDKAFEIQREHLRDYSVDAIYTNLRVATADADEKSEDLAEKFLDSKSLLIFHNILCINERIIEVHLVIVSSGKLYENYLMLQHAWSLVMNCFCSDCNQRFPYSR
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.
Subcellular Localization:
Nucleus.
Sequence:
MSEEKNDALVGEVNTDNADNQVWLIKVPKFLSESWQKIGQGEIGQIHIKGGDNISLSYGPDVGQEFQLITTANTLDNQPLKIFSEDKDGALALEGNIGLRCDIKIDVESPQYRDLMKSRHTKYNTKTRMTQVIDESELFTPTLFDANKVKVSTVGITQKKKSTDKKEKLPEDEVLDLIFSAFRAEKHLDLKTLESFTEQPKNHLKTILEKVCILNKRGPYHHLYELKPEFRDKDNSKDEKK
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MFVKAPKNLPPAAKQAKILEWFRTTMGVYSFKELEKLLPSVGSINGMLVKEYIQALTDENLIRVEKIGSGNWYWSFTSDAKKSKENMINKLKEEENKLLASMKDAEQQIEKEMMKRQEDDEILLDGGSDRHTLMDAYETLVKENDILDKELALYSDNDPTEVLRKVEETNKLKESALRWTDNLESLESFLVNLTGDRAQAGEIMSRTCGDDYVIGEGLKELVAPN
The following text describes a protein:
Function:
[TDIFp]: Extracellular signal peptide that regulates cell fate. Represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins.
Subcellular Localization:
[TDIFp]: Secreted, extracellular space; [CLAVATA3/ESR (CLE)-related protein TDIF]: Cell membrane; Single-pass membrane protein.
Sequence:
MDIDLLWSFGGWFFILFPETINYCMAKLRSTSQISHFTNPRSCSSLFFVALLIITILITMLQSSTSMEVTSLPTHQPTSSNSHDESSTSSTATTTTDLHPKRTHHQSHPKPTRSFEAGAHEVPSGPNPISNR
The following text describes a protein:
Function:
Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. May function in assembly or stabilization of the NDH complex. Required for the accumulation of NDH subcomplex A, which is a core part of NDH. May be involved in post-translational steps during the biogenesis of subcomplex A.
Subcellular Localization:
Plastid, chloroplast stroma. Note=Previously localized in chloroplast thylakoid membrane fraction.
Sequence:
MECSLQKQLFNNGDKLFSSRHNRRVSIEQVHVTDSLSVNSINLFHKPICYPISSIITSRKSKSHFSVCATRRRRVHSNSDTYVLLEAGQDEQFVTEDELKAKLRGWLENWPVNSLPPDLARFDDLDEAVDFLVKAVCELEIDGEVGSVQWYQVRLE
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MATASTATASKASIALARASTASTATATASNATAWTATGTSSKASTAPARASTASTATATASNATAWTATGTASKASTRASTASTATATGTASKASTRASTAPATASNATAWTATATASKASTAPARASTASTATATASNATAWTATASTATAMPTATAAAEGLGRQRASPDHLPVPPRPRSRYQHRAAVRPHPKAVGTPPRPAPALRHAQAEHRPVLPPRPRARPARPYNGGPFAALLYLCAVLGVAVDSCGSLRAYGGLAAVVAALIIALVLRRPPRLAHQDNADGPRQILAAPARRIQPEQPRLAPTLTITGSILDAAQVAAAIRSFMADSTRPILAVSPPQADSSDSDGSGSSTSGDDINNLWYTPLHLMKAGDVCLIHPAFIQQLQEMDPWLTEAESLELLRRAFRDANTSDGFHRLSDIVEENQGIIYDGLHVLTDGSTGASIMTMKITAKLIQLIFLELDGQNWKSCQDVKKECCFQEVVRQSVEELIDVALSFSNTRWSAHHPLQMLTILDALVDVLCTIRELTFSSTESMHDVVAHVFYKMVVDLRGMLEGTTSTSDMHSIRESAIHPATALLVRYLEFFCRNGDMMQFVLGTEDFTIELSMIYAWVSKLSEDAEAMFPAKGQRYIYILNNMDFVYQLKNHPGGCLSSVELQTGLCSLIHQYIQSYLDECWVPLLGVDSLKRFLEEFFTICDSQMTWKVRTVHKVTLRREIVGLIVPNYVNFLQENCSSHRTSWLKARSEKPMYTAVWLEEKISGFFET
The following text describes a protein:
Function:
Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (By similarity). Also enhances the activity of the ATP2A2/SERCA2 ATPase. Does not directly stimulate SERCA pump activity (By similarity). Binds preferentially to the phosphorylated E1 and E2 conformational forms of ATP2A2 which predominate at high Ca(2+) concentrations during the systolic phase of the cardiac cycle (By similarity). Competes with ATP2A2 inhibitor phospholamban (PLN) for binding to ATP2A2 and displaces PLN. Can activate ATP2A2 directly in the absence of PLN. Also enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN) and myoregulin (MRLN) (By similarity).
Subcellular Localization:
Sarcoplasmic reticulum membrane; Single-pass membrane protein.
Domain:
The transmembrane domain is sufficient to compete with phospholamban (PLN) for binding to ATP2A2.
Sequence:
MAEKAGSTFSHLLVPILLLIGWIVGCIIMIYVVFS
The following text describes a protein:
Function:
Palmitoyltransferase specific for casein kinase 1. Palmitoylates isoforms YCK1 and YCK2 at both C-terminal cysteine residues, which is required for their proper plasma membrane localization. Required for constitutive endocytosis of a-factor receptor STE3 and both constitutive and pheromone-induced endocytosis of alpha-factor receptor STE2.
Miscellaneous:
MISCELLANEOUS: Present with 4072 molecules/cell in log phase SD medium.
Subcellular Localization:
Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MVNELENVPRASTLTNEEQTVDPSNNDSQEDISLGDSNEITSLASLKAIRSGNEEESGNEQVNHNDEAEEDPLLTRYHTACQRGDLATVKEMIHGKLLEVNNDGDSTEHITGLHWASINNRLSVVDFLVSQGADVNARAGALHATPLHWAARYGYVYIVDFLLKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDCRDPKGRTSLLWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKYLIQDGADFFQKTDTGKDCFAIAQEMNTVYSLREALTHSGFDYHGYPIKKWFKKSQHAKLVTFITPFLFLGIAFALFSHINPLFVIIVLFLLAIATNKGLNKFVLPSYGRMGVHNVTLLRSPLLSGVFFGTLLWVTIVWFFKVMPRTFSDEQYTNILMLVILVSVFYLFGQLVIMDPGCLPEETDHENVRQTISNLLEIGKFDTKNFCIETWIRKPLRSKFSPLNNAVVARFDHYCPWIFNDVGLKNHKAFIFFITLMESGIFTFLALCLEYFDELEDAHEDTSQKNGKCFILGASDLCSGLIYDRFVFLILLWALLQSIWVASLIFVQAFQICKGMTNTEFNVLMKESKSIGPDGLSFNENFNTTPEGFAPSIDPGEESNDTVLAPVPGSTIRKPRTCFGVCYAVTGMDQWLAVIKETIGIKDSTGHNVYSITSRIPTNYGWKRNVKDFWLTSDINAPLWRRILYPPSGSKALLNGIEVDYFKLYKLPNKDVEQGNDMV
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSGSSAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGENFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQADNKEPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEQYSSVYASSSCSMDSLASSIDEGDATSLLKLQRYNSYDINRDTLYVSKSICLITPLPFMQACKKFLFQLHKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPNELPLSDYPLREACELLGLENLVQVFTCVLLEMQTLLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLLQFGIPPEGSLHSSESATKLKNMVLKDLANDKKNGNVPNNSVSVYELLKGSETIARLQALAKRTGVTMEKIDLPASLSEKEKDLKLQCEEADLRDSQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDSRIEKIRLYNVRAPTLRTSIYQKCSSLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPANNNRWVSRSATAQRRKERLRQSSEHIGLDSDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNWKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLLVKQGKSALWSHLLQFQDREEKQEHLTDSPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMTEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGVDDGSLERILIGELMTSASDEDLGKQCRTPPQQKSPTTTRRLSITSLTGKPAKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFKSARIFHKNVFIWDFVEKAVAYFETTDQILDNEGDVLIQKPSSKTFCHYVNAINTAPRNIGKDGKFQILVCLGTRDHLLPQWIPLLAECPAITRMYEENALLRDHMTVNSLIRILQTIQDFTIVLEGSLIKGVDV
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLVTFKTLQNTTFQIEIDPSSTVKTLKEKIEKEKGVDYPAVGQKLIYAGKILDDVSVLSEHGIDEKKFIVIMVTKPKASEPATTTPAETTTQPAATPAPVVVPAAAPAPTLATPQGDASVSTGLLAAESALIVGDDYNQMVQNIMDMGYPRDQVERALRASFNNPDRAVEYLLTGIPDRADVGEGAPGGGGQGPDEAALEFILGGRGQSEAALSMEGEGEEGDELAPGEDPLAFLRSQPQFAQMRQVVQQNPSLLNAILQQIGQTNPALLQMISQNQAAFFRMLTEPSSGTAGSASVTPASGAQPGTGSGRAAESPRQGQEEGAGDYFAPGVIHVTPQDKEAIERLKALGFPEHLVVQAYFACEKNENLAANFLLSQNFDD
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MNMIRGFRLLAMRPIYTFAADKTPATTQGKQQQAKPIQVYKDGQLITKNYLQLKKSQDIEGYVLTLVKNYYRTTNKSALSLDSELEQHGLDSLDSIELSMQIEEDLGYVISAETLPVLNKLRHYVNYIKQVEQYKVENNAAPLA
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Sequence:
MVAINEAFIKTNILDQNVNYIDACIIGAPEKICLGKSNNFQISNEEVKKVTEVFTLFRDAPIVIGGKSYTRTKSTASYIIAKHDTTGIALFQNNMGLIAIARYLDGTIEQENILKTLQHTILKALA
The following text describes a protein:
Function:
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
Subcellular Localization:
Periplasm.
Sequence:
MLGLGYLCAANNSQAQGFTAPEVLIGSTQGFLEFKVEEYLQNSGLDGRYQIQVNRVDPRLRLAECDRDLTLSQESPAQPIGRVTVRISCEGSAPWTIFMPAQVKLFRQVVVAVQPLKRAHVLEDADIALVERDVGLLTQGYLTDPARVVGQKLRRPVVNDQVLAPVFLEQAEAVRKGDQVVILARTATINVKMPGEALSDGAPGQQIRVRNLRSQRIIKARVIEPGTVEVNM
The following text describes a protein:
Function:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPDWHSSLILTAYILIFLTGLPANLLALRAFVSRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQAQLDVVLPVRLELCLVLFFVPMTVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFHLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLLRNPGSSMLGRGAEETVEGTKTDRGGSQTEGAQSSDFVTE
The following text describes a protein:
Function:
May be involved in the control of excitability of cortical neurons.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol.
Sequence:
MVVVTGREPDSRRPDGAMSSSDAEDDFLEPATPTATQAGHALPLLPQEFPEVVPLNIGGAHFTTRLSTLRRYEDTMLAAMFSGRHYIPTDAEGRYFIDRDGTHFGDVLNFLRSGDLPPRERVRAVYKEAQYYAIGPLLEQLENMQPLKGEKVRQAFLGLMPYYKDHLERIVEIARLRAVQRKARFAKLKVCVFKEEMPITPYECPLLNSLRFERSESDGQLFEHHCEVDVSFGPWEAVADVYDLLHCLVTDLSAQGLTVDHQCIGVCDKHLINHYYCKRPIYEFKITWW
The following text describes a protein:
Function:
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MERPSIKTSKKQLRSTKKLFITWSLPKNFKKTFSALSQDLLKAQKKALRKEHLLKVEAEKKRLRAILQVQYMLQALRHDHVQKDFKEGSNGAVCLSSKEMDHLVKFAKLSCQKQCHHMSLEDQMDQSSIYFWNLFEGSEKTVAGTTYKYLKELATKLLDCGYFESVRDPPVMKARKEDIPEVPPTKVEAGKAAIEEPEPPVEYAKCTSRPQGLPVRHFVALTPKPEPAKQNTDTYKATDMKYHSALKPWGMSPNVRHPEPRRWQTSPVPTPLPSTLLGPNPAPMLTPQIKQWEAMPPRLKKCDPDPKEANIPSKVQPYQMRMRVPKVPSEVEPVASIKLLSKGLTDLKPPNAVNGQLPMKRREVLPTIVANGQLPPAVNNTQPHKVPLLAVDEFCSSPTLPKDPKLRKQRLEDLIDQIKGTYNFMQDSMLDFDMPSQRLLSSQLPCETSVVSSEPKQNEIDPVLQLEEASSVSLDTQKDGVTCEMLSEPEIAEPLEPNPELENLPVAPLEEQSCLVEQITEASPDLLETLPERTTTPLPLLSDQLPSPKTPTHTSVLQLQQQCPPLSPRHTPVSMSSPFQGMQTVFKVNAPLPLRKEQELKEEPPYSTGYHQTFTTASTQTLPQCMLDTSFGDQNSFIQEPFPGSPYPSTGIQVNGSLPCYTSTPNLLPRMTPPFVSSRGTVRGTNRGRVITNGYRCPTGYKGPESYRGTQCVNNGNYVHAHCPGREYPATPFISRDGSSNLHKQRTNAITRTSSRGFSESSQMNSPEKEDSFNSIDSGLGETRSLTSLDMSMTSQAATILPVHVYPLPQQMRVAFSAARTSNFAPGTLDQPIVFDLLLNNLGDTFDFQVGRFMCPVNGTYVFIFHMLKLAVNVPLYVNLMKNEEVLVSAYANDGAPDHETASNHAVLQLFQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQD
The following text describes a protein:
Function:
In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.
Subcellular Localization:
Secreted.
Sequence:
MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVSGEWPWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWPWDARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGAYTHPEGGYDVALLLLAQPVTLGASLRPLCLPYADHHLPDGERGWVLGRARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGAPLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGSCLANISQPTSC
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MLFMSAYYSSDKMDHRTRTAYTSAQLVELEKEFHFSRYLCRPRRVEMASLLNLNERQIKIWFQNRRMKQKKDQRARGLTASPCSPPSSPSAGASPTLASLGYVHVGGDYLQASPPLKPQNAQLAYPTEFSKYPDPDLTCGPQFEAQYNSPGGGDLSGPYLSQSCTPQDRILQAPRLTSPSRLSIWRCQSLCRSQRHGDRCSKLGEWREMFFTFESEPSLFAACMEGKEQIVEQIELNTNRKH
The following text describes a protein:
Function:
Probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Sequence:
MQYKNLGKSGLKVSTLSFGAWVTFGNQLDVKEAKSILQCCRDHGVNFFDNAEVYANGRAEEIMGQAIRELGWRRSDIVISTKIFWGGPGPNDKGLSRKHIVEGTKASLKRLDMDYVDVLYCHRPDASTPIEETVRAMNYVIDKGWAFYWGTSEWSAQQITEAWGAADRLDLVGPIVEQPEYNMFARHKVETEFLPLYTNHGIGLTTWSPLASGVLTGKYNKGAIPSDSRFALENYKNLANRSLVDDVLRKVSGLKPIADELGVTLAQLAIAWCASNPNVSSVITGATRESQIQENMKAVDVIPLLTPIVLDKIEQVIQSKPKRPESYR
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MSSFVVAALLAVAIATQALEEDFAFDVSDDFEVEVNAGNREIEAAVGKVFHYVVPQVAATGGFEARRSDGSPLPSWLLFDKIGAVFWGVPLGDDVGSLHLVIRNRNISEDVTINVRETSDLKDRCPSTEDNTVLILLIDKGVRAIKPKQRVIAVNNVAKFFGLPYSAFTLKPQLEKDDITDSSVVLAGPGNFKPKSAKSTSVKVAVGCDGRLWVQTAPLVHQLKQQARDGTISEVLGLPLIGWRVKTEPKSSRTKRQTEDYGSGDYDDDYYDNYEDEYEYEEEDTKSSTTTTVSPTPTHPHRHHHGESLPEETHHQNQETSSQVVPTTVEMVPETTTTTTTPKPTTEETPLVTNATKIDNSYEYEDYDYDLEENEEDPIESKIVVPEFVPKPSETTEATTTTTAKSTTIQVVETVPTVPTTTERETTMMIIEDTEPATVLYETTNLIPETSPVATTDFSTTTATITTTTEEEELPTTPSTTTRHVVTSPRTTEMTESVELEEKNFPPYIENRLKQMSVIAGKIFRFVVPKNTFNDFEDGHNLTLEFLNSRGEPLSKDSWCHFNPHRREIYGLPLEEDVSKWEYVLKATDREGASITDVFTIQVQQHKLQRVVNHEISLFMRIEKQQEFPHFVDWCLKTLRALGKIYNTNMTEITVRNVNYTSEPVVFTWTNDSIPTNYCPVEEIDKLYKMLTANDRGDPKQELSLLLTPDLRVKKVTKHGLGVCETPQVPVTPPTNFSPFLRNPVDHINATVGELLIFKVPDDTFYDPEDTDSRTLNISLLTGDRQAIKSTNWLQFDSKNREFYGIPRKPGRSEYHLVCVDSGGATATDSLEIVVYPAHKMHYNVEFSMTVETPYDTFVNSASMQRKFVEKLQEIFGDRNSSSLYFNPFKQKDHSTVITWFNRTLSTSKCPHDEINHLESVLKNHQDRGISHQVSRIMEPEFLVSKISVFTMGNCRTKSLPPPVHEDVIPVDEKSPDASAAQYQYLMTFIIPAVIISIMLFFAALCACVLYRRRRTGKLNVEEDGRQSYGNKGIPVIFQEELEEKPESGTKTPVILKDEKPPLAPPEYSKSGSLKLTDDSEPYQPPPPFTRTDGRQPRPKPTPTYRKPPPYVPP
The following text describes a protein:
Function:
Major role in the synthesis of nucleoside triphosphates other than ATP.
Subcellular Localization:
Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm. Mitochondrion intermembrane space; Peripheral membrane protein. Mitochondrion matrix. Nucleus.
Sequence:
MLQPRMFQTLLQHFSPEIQRTSTRLLFGVSHALRHGHRCGLHQSKAALQNARERTLIAVKPDGVQRRLVGQIIHRFEQRGFKLVGLKMVQASHGILSEHYGELRTKPFFHSLLTYMSSGPLVVMVTFSFGSWFLLSLFLVFAVPYYCSIYRYGKVTMSSRRHEKWWDKQILLRRRRAPSEEILASMLAGNPISWDLLFPEELRVQQKFNFEILGHS