lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MNSFMMLSSAAFGLPVVHAKVAANSADSVDSKNCAAKVKVSSIPLYPEPVSWEYSAKPASQLEELVKKTRIEVTNTKAEYQPVLDKITHVVETGIAHTNQALFQVRNDTTTRVGIMALGGMVAGLVAARRRGLYNKMTAVLIGVGGTGVLCYPDQAKVLAGDAGKLAVKNARIAYHFIVGARPPIQNENGKPFERVMGMTSDIGKWGFNLFQKKNPTNVESEVITPEPAPESQQEESKPLEKSDSTDEAPAPGPAEVKENAPPSEIIKETSIDSTTESNGEVVVSAVEVEVSPAAPESPQIHEENIESAPSAPSTTTSCSDTVPSEDALIPEAETTAPIEQEIPQVEEPKNGKLETAPTPAATTVYEGDLGQGTLEDKELYTTRE
The following text describes a protein:
Function:
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MEAATEFVVESPDVVYSPETIEAQYEYRTTSVSREGGVLKVHPTSTRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLSWPTRTGRKEANYYGSLTQAGTVSLGLDAEGKEVFVPFSSLLPMVAPDDLVFDGWDISSLNLAEAMRRAQVLDWGLQEQLWPHMEAMRPRPSVYIPEFIAANQSARADNVIPGTRAQQLEQIRRDIRDFRFSAGLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIQLGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQRRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGQNLSAPPQFRSKEVSKSSVVDDMVHSNPVLYSPGEQPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDVDPDPQSFHPVLSLLGFLFKAPLAPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKMERPGLKRVGPLATTSPVLCKKGSAPTAPNGCTGDANGHSQAEAPQMPTT
The following text describes a protein:
Function:
Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.
Subcellular Localization:
Mitochondrion.
Sequence:
MKLDLVKRTFNYAVVNKPSGMVCDASHTNNIITALTNEFTKILPSVNSSQFRLVQRLDRFVTGGLVVARNKKWADKVRKSFFQEGTLRLTRRYVGLIALDQIPESTQGTIDFPIQALEKDYRGKNKSRELFTYSAVTHYKLIPSARRTIKGVFPVFQQGPILPIILELETGRKNQIRDHIIQKFGVPLLNDDNFSDFKLNSEIPKDVNSKLYKSNQIALHSGLVIMENNGISQQFLFPVNNAYDRELW
The following text describes a protein:
Function:
Probable transcription factor. Binds to DNA sequence motif 5'-CTGTTTCA-3'. Required for the migration of distal tip cells (DTC) and axonal growth-cones along the dorsal-ventral axis of the body wall, acting by cell autonomous repression of unc-129/TGF-beta expression in ventral body muscle during embyogenesis. Binds to the promoter region of the unc-129 gene. Plays a role in dorsal-ventral patterning and fate specification of the postembryonic mesoderm. Involved in male tail morphogenesis and in embryogenesis. Plays a role in the development of sensory neurons and is required to repress AWA fate and promote ASG fate in the ASG chemosensory neurons. Regulates expression of a class of small RNAs, known as 21U-RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MLFSMESILSSTKPKLEPPPKLEPEVTINEQVVDLPRSNTRLSEPSTSASVLEHDLKFGESRKRSRSLGDEPTEDEDGVPVRKANKRNHSTSSAADSSSDDAKDDDDDDDSTSRKSMSGHRKSSHAKPPYSYIALIAMSILNSPEKKLTLSEICEFIINKFEYYKEKFPAWQNSIRHNLSLNDCFVKVARGPGNPGKGNYWALDPNCEDMFDNGSFLRRRKRYKKNSDTYHEMMSHHPMPFPPFLPQGMPFPPRMMHPMANIPMLGHPMNPRAVPNMPAFFIPQNIDSQKLLSMMASRIMPMDAPVSSGQKRTSSSSSPNENGSSAVSDKLSA
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Sequence:
MADLVSGEASESDEELQEKNKIFAAEISGEASEEDDEDIYEQGRSSNQVNSTASIYRNNLLQRKLIENNIAIWRSLTAFTRSFVLSASKQLVTTDQMLIKSQHSLQSAHTSLQQAQKNAQDLQNRVADVITSNFLPHISIQKAT
The following text describes a protein:
Function:
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Sequence:
MPEKMSLRLVPHLACIIFILEIQFRIADSNDPCPHNQGIDEDIAESILGDWPANVDLTSVKRSHKCYVTCILQYYNIVTTSGEIFLDKYYDTGVIDELAVAPKINRCRYEFRMETDYCSRIFAIFNCLRQEILTKS
The following text describes a protein:
Function:
The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity.
Sequence:
MGQQTSFKYANDSNIERAERRLMQAVAQNSEGIDLIFNKLEPIDFFATPFKLIFQTAKENYQLNNPIIGSGLLEAVKFKLDANDQSTKSELEILFTKILLIRLPPNQTEIKTLVDVVKKASIFRRLQQFAKRVYNEEFKLKEDRFEGYLQAIQDDFVKIIHSAFSNIFAFSYDEIANQEEALIKKVHRGELIISGLSSGFLKLDQLTSGWKPGELIVIAARPGRGKTALLINFMASAAKQIDPKTDVVLFFSLEMRNREIYQRHLMHESQTSYTLTNRQRINNVFEELMEASSRIKNLPIKLFDYSSLTLQEIRNQITEVSKTSNVRLVIIDYLQLVNALKNNYGLTRQQEVTMISQSLKAFAKEFNTPIIAAAQLSRRIEERKDSRPILSDLRESGSIEQDADMVLFIHRTNDDKKEQEEENTNLFEVELILEKNRNGPNGKVKLNFRSDTSSFISQYSPSFDDQYS
The following text describes a protein:
Function:
Involved in EDS1-dependent systemic acquired resistance, maybe in phloem-mediated long-distance signaling.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MESYLRKWCLVSVWVLLLGLGFKVKAEPQVPCYFIFGDSLVDNGNNNRLRSIARADYFPYGIDFGGPTGRFSNGRTTVDVLTELLGFDNYIPAYSTVSGQEILQGVNYASAAAGIREETGAQLGQRITFSGQVENYKNTVAQVVEILGDEYTAADYLKRCIYSVGMGSNDYLNNYFMPQFYSTSRQYTPEQYADDLISRYRDQLNALYNYGARKFALVGIGAIGCSPNALAQGSQDGTTCVERINSANRIFNNRLISMVQQLNNAHSDASFTYINAYGAFQDIIANPSAYGFTNTNTACCGIGRNGGQLTCLPGEPPCLNRDEYVFWDAFHPSAAANTAIAKRSYNAQRSSDVYPIDISQLAQL
The following text describes a protein:
Function:
Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves. Facilitates the transfer of a spectrum of different lipid molecules, including sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, and phosphatidyl ethanolamine. Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (By similarity). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (By similarity). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (By similarity).
Subcellular Localization:
Secreted. Nucleus. Note=Nuclear export is XPO1/CRM1-dependent.
Sequence:
MVLLWALFLALLAGAHAELPGCKIRVTSAALDLVKQEGLRFLEQELETITIPDVYGAKGHFYYNISDVRVTQLHLISSELHFQPDQDLLLNISNASLGLHFRRQLLYWFLYDGGYINASAEGVSIRTGLQLSQDSSGRIKVSNVSCEASVSKMNMAFGGTFRRMYNFFSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDDLVGIDYSLLKDPVVSNGNLDMEFRGAFFPLKEDNWSLPNRAVEPQLEDDERMVYVAFSEFFFDSAMESYFQAGALQLTLVGDKVPSDLDMLLRATYFGSIVLLSPTVINSPLKLKLEATSPPRCTIKPSGTTISITASVTITLAPPMLPEVELSKMIMEGRLSAKLTLRGKALRVKLDLRRFQIYSNQSALESLALIPLQAPLKTLLQIGVMPLLNERTWRGVQIPLPEGINFVREVVTNHAGFVTVGADLHFAKGLREVIDKNRPADVAASHVPPPSAAAA
The following text describes a protein:
Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MARFVVLVLLGLLYLSHLDAVQHSPKVQVYSRHPAENGKPNFLNCYVSGFHPPQIDITLMKNGKKMEAEQTDLSFNRDWTFYLLVHTEFTPTVEDEYSCQVNHTTLSEPKVVKWDRDM
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAVNLRWNRTHNLCLSVIYILATLQLTLGLALPRINVPSNALPGFKVTEVKKSGQFSELLSDSDVHNLFQIAENGALEIKNSLEHLANSDIALKVRHTLRGQSWDDLLNLHVEDTSLEFSKKSYRGYVFESHEAIQEVMGLDDLQIASTKPVSYQLAGEDSANFRLQVNPEGRVQIFTSVPVDSETTSQFHMEIKASAQDLLGNPPLMSLPAEVTIIVRPLSNNFRPFGDDIMYPPNEPVKMVRVRRDVLPGESVNLTESTAMDTVVHTITETGADLRYAMGTPVNDKFSIDEMSGDVTLLQSVDYEAYSTNPQEILNVQITNTSDPDALDTLVVTFDILDADDLPVWTMPVYPYIAVVPTDAPNQACIYTLEASDQDLGSDITYSLRAGGDGAFTVGETDGCVYTAIVSGFPGYVQDLEYILSVMATGTSGSFDGGVTGTVRVYGGSYPPQFSQEEYSASVLEDQANQAVIQVTASSFSRNVPLTYSIVGPENRPSHTINANDGTITLVDAILAEDLLSYFLTVRATEQVVDGLSSEVRVNVMVEDVNNCVPTFGQDILSFNDVLETTAIGEPVGTVTATDCDVGPNAELTYSITTPNSGFTIGSDTGVLSPAVVLDYEEGDRYYTFAITATDGGTPQLSSTATVVISIANAPEAPYFTPPSYRFRMDEVAQVNYEVGTVYASDDDVNDVLTLSIDGGDGTFRIDQFGVISVARAAVESSYMFAVVASDIANNEANATVEISVTDLNDNIPIFPECDNYRGEVSEDATIDTDVITVTATDSDQGSNAEISYKLSSNSDASRFFRVDQNGLITTNTLLDRETTAVFEVTVEAEDDGNPALTGFCTFTVEVTDVNDNFPAFPFTGYQTSISTSAASGDEVIEVRADDLDLNSDLTYSLSAADGGECDTGYFTIFPATGSIIVRQDLTPLIEFGSPNEQDCIVTATDVGGQATDVPVQIDVRSSDDDTYQVPTFSATSYQVTINENSMSQEVLLVSVLGAAQVGFNIIRGSRPSTNYNRNFGLSNDDDEFTSSYITVLEALDYESVTRYDLIVTARYPNSPYTVETNVIIDILDVNDETPIFPAFTFYGNIAENQPLPNLDPVITLEATDSDVTPEFSQIVYSIDGDQTDFRIDANSGAIFAITEFDREAVAEDTIPLTVIASDGINESRATVFITIVDENDNQPEFNGTFSFDVSEDVEMGYEIGMVTATDADISEDLEYFISGGNVGGAFTVVANTGAIRKAGVLDYESLTSYSLDFSVNDGFNTETTTVVVNVINVNDVAPQFGESSYSVTVLEEDDSDIPRVLLTVAATDGDADAVADAVVYDLLGTGAGTLFTIDPQTGNITLTGVLDREEIPRYVLSAMATDDNGNGLSSYVDVIIEVEDINDNFPFFPDQEYVGSVDENMPPNTPVLAVVAEDPDTADNLVYSFPTPNSDFNIDPDTGEITTAIQLDRETPPSEYELEVQVTDGTNTATTPVIITINDVDDNRPVFTQDPFPPASVLETEPVGTTITTVQVTDPDVDHMDKVVFTINSGDDADLFRIVPDAATLSGLIQVNKPLDFESGNANDFTLTIQVEDSQGTIGTPQTTTIEISIENANDLAPVFEEDMYAGAVSEGADVGSQVGTFTLTATDGDEPGGVLNYVIDPSTDPEGQFGIDANQRLVVASPLDRETVASYELKVYAVDNGDPPMSGTATINVVIEDVNDTPPRFAEDYTPSVKENSDAVAEVVSVRAVDDDDPASGPPFLYRVAGTPNEWTDYFTIEGLGTETSGDITISTSGRAIDREAIPYFDIVFLIEEVNTDERLTGTQTLSIMVTDVNDNPHLAATKNILVYSYEGEIPEVSLGNIPTTGVGKVAVEDPDILEDKTYTAEGEFPDGFQLDTDTGDIVMLEGTPAGIYTMQVMVSDGGMFPDVVSTVIVTVKDIPQEAVFSSGSIRFSGTTAEELIDPNAEGVSKLDSLKVILAEAAGAQLENFDIFSVLNVEGMERTVDIRYAAHGSPYYPADKLDLAALSVSDQIAALGLDIAQLPVDLCVKENVCESSCTNVLVVDPTPTVVDSGSASFVAITSVLQAQCICGARTEAPGSCDSIPCLNGGTCVDVHGGTYKCECPYLFDGPNCQQTKRSFNDGYATFSTLRQCEETSLSIEFITETPSGTLFYNGPIQPTEVDDAIDMILLELTNGKAKLTINLGSVDGTTLNLELEVPKDNLGDGQWHRIDVYRNGRSVEMTVDRCEDAPFAETSSSSTLDTSNCRISGETPGENKFLNVNTPLFLGGMSPDYNPDVVVPGGFDGCIKNLVSDGFLYDLADPGIFDKSDSGCLRTDGQCTVDGEPVCENGICEADLGSFVCICFPGFNGEFCSIVLPPYDFATDSYITYELLDESLYNDARSSNYHIMVRSRQENGLIWSISSANTYEYIRMEMVAGELQADWHLGDKPVSVTMGNFSINDGAWHAINFDRYDSVVTIKIDGGGGVKEIQNRESAFSGLDIDSNSLVIGAFVDLNTVTDDFMGCMNDPRIDNNFLGMEGSNEYATATQSAGVSEGCPSEVCDSNPCPGQDLVCTDYWRFYECECPVGEELSGPETCLAIIDCDPNPCYNGGTCTEGVPTGFNCTCAPTYYGTQCEATIGGQGASLGITPLGIILMIICILLIIILLLGLVLYTRQRDRKSALTFAIDPEDDIRENFINYDEEGGGEEDNDAYDLSTLRKPVDAISAGSIEKKPAMPVSEVPVGNRPSGVDPNVGDFINDRLKGANDDPEGPPYDEPHVYDFEGDGSSAGSLSSLNSSSTESEQNYDYLNDWGPQFRKLADMYGS
The following text describes a protein:
Function:
May transport divalent cations (By similarity). May participate, with dstA, in the regulation of the differentiation of stalk cells during development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGISLSVLDIKIISTTVLFILSLLAGIAPYWMRNLNNSSRYLSWSNTFAGGVFFGAGMLHLFATADEDLQPYVQKYNYPFAALCLCVGFLITLFLELIINSIFIKSNTFASLHGHSHSHVHLSHGHSHHGKDNGSNGNPGSGVGIGMGSVGALNSKKNKTTSPTITPTTPSEGTTTTTTTTTATTAATAKEIVLEDEDEDEEKDIMDEIIIPDDYDENDDEQIYKKKQSKCARTKFRKFIDTIPTFSSTSTSSTSSSTKISEKQRLLDSSNSYYYNQNKYKGIIGSHIDIDKSGSGVGGFSNNNNNNNNNNNNNNKNNNNNNNNNFRTEIIIQPISTTSNNSVHHYPSSSVNYHPFITTTTTTCSNDNSNSNNNNSSNNNSSSANITPNTNKILSSSKSLSYRYNGDDEEPDIIIDYDDIDYNQEGRTRGNSLGSDSNVHNERIVLINSGIGNSGNIGSNNNNNNNGGGGGGGGNSNIDYNDNEENNNNNNKIESEILIKDTTTDSIKNMKGGEHQHQHLHQQEIIVVTKKSNILLPFILVIALSIHSLFEGLAMGVQSSEIRVFDILIAIFAHKILASFALGISTITSSNEKPSFLKLFLLVFVFSLTSPIGSILGMVIVGSGVTGSMVPPILQGIASGTFLYVAVVEIIPKELSHDSNDILIKSFLLLLGFSGMAVVAIWV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.
Sequence:
MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMGRKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTGAQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDTSAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISPRAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKVPAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPMVTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPAVNALHEVFELSK
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKLDLFKWEKPAWIVSSLLVLISIFAMAISWAQFQAPFRPGLDFVGGTRLQLQLECASSNNCPAAIDVAEVQDILGGVGLGNSSVQVIEDYTLSIRQQTLDVEQREAVQKALNEGIGKFDPETIQIDTVGPTVGKALFRSGVLALVISLLGIIIYLTIRFQLDYAVFAIIALLYDALITMGAFAIFGLVGGVEVDSLFLVALLTIIGFSVNDTVVIYDRVRETLERHSDWDINHVVDDAVNQTLTRSINTSLTTSLPLVAIFLFGGDSLKFFALALIIGFASGVYSSIFMATTLWAWWRKWRSPKNPPREMVAEV
The following text describes a protein:
Function:
[Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation.
Subcellular Localization:
[Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Lysosome; [Bis(monoacylglycero)phosphate synthase CLN5]: Membrane; Single-pass type II membrane protein. Note=An amphipathic anchor region facilitates its association with the membrane.
Sequence:
MAQVGSAGPGACGRRGAGAGAGPERTTWRWAPALLWLATAAAVAGDPSRRQWPVPYKRFSFRPEPDPYCQAKYTFCPTGSPIPVMKDDDVIEVFRLQAPVWEFKYGDLLGHLKIMHDAIGFRSTLTEKNYTMEWYELFQLGNCTFPHLRPEMNAPFWCNQGAACFFEGIDDSHWKENGTLVLVATISGGMFNRMAKWVKQDNETGIYYETWTVQASPERGAERWFESYDCSKFVLRTYEKLAELGADFKKIETNYTRIFLYSGEPTYLGNETSVFGPTGNKTLALAIKKFYYPFKPHLSTKEFLLSLLQIFDAVVIHREFYLFYNFEYWFLPMKYPFIKITYEEIPLPNRKNRTLSGL
The following text describes a protein:
Function:
As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MKLKELEKPAVQAWSPAKQYPVYLATGTSAQQLDASFSTNATLEIFEVDFRDPSLDLKRKGILSVSSRFHKLIWGSSSSGLLENTGVIAGGGDSGMLTLYNVTHILSPGKEPLIAQKQKHTGAVRALDFNPFQGNLLASGASDSEIFIWDLNHLTVPMTPGSKSQNPPEDIKALSWNRQVQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSSRMNCSGLAWNPDIATQLVLCSEDDRLPVIQLWDLRFASSPLKVLESHSRGILSVSWSQADAELLLSSAKDNQIFCWNLSSSEVVYKLPTQSSWCFDVQWCPRNPPAFSAVSFDGWISLYSVMGRSWEAQQHMRQADKVPEQVAQASLIPPLKKPPKWMRRPAGVSFAFGGKLVTFGLPSIPVQQVPQPCPRPVFISQVITESEFLTRSVVLQEALGSGNLLNYCQSKIQQASRPSEKTLWQFLKVTLEHDSRLKFLRLLGYSRDELQKKVDTCLKSDSKSQESPQLEAVDLKSDRAHTLCSQASRHTAKEASASSAFFDELIPQNMTPWEIPTTEDTDGLLSQALLLGELRSAVELCLKEERFADAIILAQAGDAELLKWTQERYLAKRRTKTSSLLACVVKKNWKDLVCACSLKNWREALALLLTYSGPEKFPELCDMLGARMEHEGGRELTSEARLCYVCSGSVERLVESWADSQQASSPVALQELMEQVTVLSRSLELLQGSHKMSPGPATTHRFTQYASLLAAQGSLAIAMSVLPSDCTQPAVLQLKDRLFHAQGSTVLGRQAPAFPFPRVAVGAALHPKETSSHRMGFQPPRQVPAPSVRPRAAAQPSVMPFLPSHPIPSVGSWTQSSSDYRVPKPQATLPVHFVPGVRPAFSQPQPFGGQSVQAINPVGFCGTWPLPGPTPVMAPPDVMQPGSTHLPETPRLLPLPPVGPPGPTPLSSQPAASPVTFSVAHPPGGPGAPRSSALPSSGILATRPGPQDTWKVAPASQENLQRKKLPETFMPPAPIITAPLMSLGPEPQQALLPQSLVSGASLPPPGAPRECSLQKTKRKLDEAAHRLECLYEKLCEGTLSPHVLAGLHEVARCVDAGSFEQGLAVHAQVVSCSSFSEVSSFMPVLKAVLTIAHKLQG
The following text describes a protein:
Function:
Probable alpha-1,3-mannosyltransferase involved in the N-glycosylation pathway. Involved in glycosylation of the TNF receptor grnd, regulating its ligand affinity. Required for normal epithelial growth and architecture. Suppressor of JNK-dependent intestinal stem cell proliferation.
Miscellaneous:
MISCELLANEOUS: In strains Harvich and Apxo, there are 2 genes which code for l(2)not/Alg3 protein. They differ in their C-terminus.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAPPKAASHRPAVRRKKSGTLVDSILDKYLNVRFFKYLLLEPAALPIVGLFVLLAELVINVVVIQRVPYTEIDWVAYMQECEGFLNGTTNYSLLRGDTGPLVYPAAFVYIYSALYYVTSHGTNVRLAQYIFAGIYLLQLALVLRLYSKSRKVPPYVLVLSAFTSYRIHSIYVLRLFNDPVAVLLLYAALNLFLDRRWTLGSTFFSLAVGVKMNILLFAPALLLFYLANLGLLRTILQLAVCGVIQLLLGAPFLLTHPVEYLRGSFDLGRIFEHKWTVNYRFLSRDVFENRTFHVSLLGLHLLLLLAFAKPIWTFFQSYVRLRRIEDQLQPQITQQNLQLKAQKRPKKVEKDKDKDQKKFTTEQQSFLKAFEKSLQKASGGKATPAPAQAEPERYGIHFDRCTQLALLPFFLCNLVGVACSRSLHYQFYVWYFHSLPYLAWSTPYSLGVRCLILGLIEYCWNTYPSTNFSSAALHFTHIILLAGVAKQLIQTMRINNAAKREQQEQQKKLQ
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MSNIYEEKVTMIAAGDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHEKQKESWHLRKGVSDIGEEVEYDEELYVAGNMVIWSKGSKSQASAVYKAFTVDSPVLQALWCDFIISQDKSEKADSISEVEKCICILQSSCINVHSMEGKDYIASLPFQVANVWPTKYGLLFERSSSAHEVPPSPPREPLPTMFSMLHPLDEITPLVCKSGGLFGTSRVQYVADSAMKIVFLNTDPSIIMTYDAIQGLHSLWILRRVKPEEQNVVLKFSEQGGTPQHVATSSSLTAHLRSLSKGDSPVASPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRSHSPALGVHSFSGVQRFNFSSHNQSPKRQSVSHSPNSTSNDSFLTPEMEPIIPELCIDHLWTEVITTTREKNSPASKVFITSDLCGQKFLCFLIESQLQLRCVKFQETNDKTQLIFGSVTNLHAKDAAPVEKIDTMLVLEGNGNLVLYTGLVRVGKVFIPGLPVPSLTMSNTMPRPSTPLDSVSTPKTLSKPLGSLDEVVLLSPVPELRDSSKLHDSPYIDDCTFQQLGSYIHSVRDPVHNRVTLELGNGSMVRITIPEIATSELVKKCLQAVKSILPKEIAVQMLVKWYNVHNAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWIRNLDFEGSLSPVIAPKKARPSDTGSDEDWEYLLNSDYHQNVESHLLTRALHLNPLEVSQMKEDVLHNLTLDSSTLLFTQIPAIFFVLHLVYEELKLNSLMGEGIRSLVVLLVQLARDLQLEPYLDYYYRDYPTLVKTSRQTCIIDQAQTGFMHHPSFFTPEPPSIYQWLSSCLKGEGASPYPYLSGVCERSKLIVLSVALYILGDERAVSNEASQYLSKVTSAPKKIQMDQNDNRFSFRHSTPVNSLAEKLVLWMTNVGFTLRDLESLPFGVALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTEAEEEDDGMNDMNQEVMSLIWSEDLRVQEVRRLLQSAHPVRVNVVQMPEVNDHEYIEEKENRLLQLCQRTMALPLGRGMFTLFSYHPVPTEPLPVPKLNLTGRAPPRNTTVDLNSGNIDVPPNMACWASFHNGVAAGLKIAPASQIDSAWIVYNKPKNAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVIGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHRRFQAGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSISLNETEIPTSEDLNLETLAQAHVYIIAGACLSLGFRFAGSENLAAFNCLYKFAKDFMKCLSAPTASVTGHYNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFMHKKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPVHSTDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEETTEELMAPTLLPELHLLKQIKVRGPRYWELLIDLSKGIHHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVTHRNSEARAFKPEAISAFTSDPALLSFAEYFCKPTVNLGQKQEILDLFSSILYECVTQENPEMLPAYIAIDQAVRRLERREMSETFELWQIKLVLEFFSSRSHQERMQKTPSRGLFMNSEFLPVMKCTIDNALDQWLQ
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MADVLGSLGFTQDLPDDSAELDDFHLLSNALRNERNTQDILEYKHDLVERVQRRLQEQADRVDTWKEAGKNQYDDVDMSLPILCSTLNVNRFRFLLKAYWRARLQKIERFATLILDKQELQRHCSPQELSHCLQYFVAVGKCLKEVVLAKLPEEFQTLVQESQLTEARDMIPAPRLDRCVFIKLLKDAGHVAVDAEGTQLVDMKAGDIYIIQYSLVQRLVQQDIAVLI
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MQKNLVIVESPAKAKTIEKFLGKDFKVLSSYGHIRDLKKKEFSIDVDKNFKPDYEIPADKKALVSTLKAEAKEAETVWLASDEDREGEAIAWHLYEVLKLKPENTKRIVFHEITKGAILKAIEQPRNIDLNLVNAQQARRILDRIVGFELSPVLWRKVKPSLSAGRVQSVAVRLIVEREREIHAFKSEAAYRVIAIFLVPDTDGKLVEMKAELSRRIKTKEEAKAFLDACKGATFTIEDITTRPVKKTPPAPFTTSTLQQEAARKLGYTVAQTMMIAQRLYESGFITYMRTDSVNLSEYATASSKDAIIQMMGERYVHPRHFETKTKGAQEAHEAIRPTYMENQSIEGTAQEKKLYDLIWKRTIASQMADAELEKTTATISISKSGDAFTAIGEVIKFDGFLRVYRESYDDENEQEDESRLLPPLKKGQKLEYGPIVATERFTQRPPRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVEKGNKDGEERTFNVLTLKDNQIKDESHNEVTGAEKSKLFPTDTGTVVNDFLTEYFPDILDYNFTASVEKEFDEIAEGEVKWTSIMKTFYDQFHPAVEKTLSIKTEHKVGERMLGEEPETGKPVSVKIGRFGPVVQIGAADDEEKPRFAQMKKGQSMETITLEEALELFKLPRTLGEYEGKTVTVGIGRFGPYIQHNKVYVSLPKTLDPMKVTLEEAEQLILEKRTKEAERHIKKFDEEPELEILNGRYGPYIAYKGNNYKIPKDIVPQDLSLKSCFDLIKIQDEKGPGTSAKGKRTAKKK
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol (By similarity). Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism (By similarity). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (By similarity). Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAPWAAAQLWALNPLRALWLTLAAAFLLTLLLQLVPPGLLPGCALFQDLIRYGKTKREGQSRPAVCRVFDVPKRYFSHFYIISALWNGFLLWHLTQSVFLGVPFPNWLHGLLRILGASQFQGGELALSAFLVLVFLWLHSLRRLFECFYVSVFSNTVIHIVQYCFGLVYYVLTGLTVLSQVPMDGRNAYVIGKNLLMQARWFHILGMLMFIWSSVHQYKCHVILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYISMAVTFGFHNLTWWLVVTYVFFSQALSAFLSHKFYKSKFVSYPKHRKAFLPFLF
The following text describes a protein:
Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the epha2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MELSLVVFTVVCWVSVWSDDRIISDRHAVYWNSSNSRFWQGEYTVAVSINDYLDVYCPYYESPQPHSRMERYILFMVNHDGYLTCEHRMRGFKRWECNRPQSPDGPLRFSEKFQLFTPFSLGFEFRPGHEYYYISSPHPNHAGKPCLKLKVYVKPTSSGYESPEPFLTDQSQRCGADGPCLAVLMLLLVFLLAGV
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Sequence:
YVISAIPPTLTSKIHFRPELPSERNQLIQRLPMGAIIKCMMYYKEA