lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip cell (DTC) and in maintaining their sharp tapering morphology. In addition, plays a redundant role with max-2 in DTC-mediated guidance of gonad elongation. May phosphorylate mlc-4.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, axon. Perikaryon. Note=Co-localizes with ced-10/rac-1 and cdc-42 at hypodermal cell boundaries during embryo elongation. Preferentially enriched at pharyngeal muscle cells boundaries. In CAN neurons, detected in the cell bodies and along the axons. Remains diffused in the cytoplasm during distal tip cell (DTC) migration.
Sequence:
MKAFSSYDEKPPAPPIRFSSSATRENQVVGLKPLPKEPEATKKKKTMPNPFMKKNKDKKEASEKPVISRPSNFEHTIHVGYDPKTGEFTGMPEAWARLLTDSQISKQEQQQNPQAVLDALKYYTQGESSGQKWLQYDMMFIDDAPSRTPSYGLKPQPYSTSSLPYHGNKIQDPRKMNPMTTSTSSAGYNSKQGVPPTTFSVNENRSSMPPSYAPPPVPHGETPADIVPPAIPDRPARTLSIYTKPKEEEEKIPDLSKGQFGVQARGQKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRCAKPLASLYYLIVAAKKSIAEASNS
The following text describes a protein:
Function:
This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.
Sequence:
MSGVYDRFNRGLSNGIRVVDAGERMIANEQQQQQQSLWIQQQAKDQEELRIIRTKLLEMVKIMEMHRQNQIKREEETEAEIANMKKAKWRQIYYSTLKEKKAVNEEEEESLEESEPELEPNTTPQLPLSLLTTPPTPLPSFPSPPLLEQELLKEGTMGFILNPKELHKKRNMPPLASPPSTPPRPQPSSPQSLGSKYSSGAAILNTRGVNRYDRKMEVHMFDSYRPPPPTPPPPLSGIQSMRKGTIDSMPDQAGMNLLLRWVFSQDGMRTECQLRYWEITVPLKLGHYRYGLKKNIWAEIRMLRMGLHKLGHTTASTMNDERKLSPKESKLAVTNSALQLETSYFSMLAPATQLPAAASDSRKIFESITTLHYQWCFYRELLKLLGESGLKDAGSCGISPKYPTKQEGQLSPQPSWHSILCCLGLSRQLEGFIRDVAFYPTMWSTPGLVPLQLYPLTDKRTKHVVSIGENHRIVDIPVSNCLNNISKFYVVTKINSATHNRHLSCVYASNRGIGKDEGLVEVVAAQQILKNPNEFLDTINEVGWNLELHEEKNVLEYQLLAGNHVYLMNYRRFIQTRRETNADTSVLILPTHEKHAIGFGLTVIDEERDKEILDNVSKGKYVVIKDLMLRWLQDKFPRTNGSGSEANLGLEAELASLGSKGFNALVTFGGVSLYITLNPYENGLEVMKKGEYAQVISEVPHKFKNVFEVMKTPREGLSFQYHYFPSGVMSNTNGKADEVVKMILEELEPMGVVELVEEVIVGHATKQGFELGETEGEQQQQESLKKKFAEISIYSFKLLMLHVQFELLRYVGSIR
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
Sequence:
MDFKVLVVEDEISINDILVSALRADGYKVKGVFLAKDAKDALDFFHPDLVLLDINLPDESGFELCRHINDKCCIPIIMLTARNDIVDKVLGLELGADDYITKPFNIKEVLTRVKVAIRRVNKYKEKSDKEFIYINKFVKVNLEGRIVFKDDKEVKLKPQEYELLEFFVKNRNIVFSREILLNKVWGFDYEGEVRTVDVHVRRLRSKLDKENATSIIDTVFGIGYVMR
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MIAAKSQVALGRRAPVRGQRVVAAASARPTWLPGLNPPAHLKGALAGDNGFDPLGLGQDEGRLKWYAEAEKTNGRWAMMAVAGILGQELLGVTPAWWEAGAKEYDIPAQALTPIEFIVMGFLEIKRYQGFKQTGTSGFINSFPFDPAGMNSPSMATKEVKNGRLAMVAFIGFCVQALATRTQPIEGLTAHLADPFGKNITYYLTHLPETLGSA
The following text describes a protein:
Function:
Structural subunit of tRNA-specific adenosine deaminase, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A. The wobble inosine tRNA modification is essential for cell cycle progression in the G1/S and G2/M transitions in fission yeast.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVKTNISKNSPKEATVPELDWPFKLIKSHLETRKLETENVWIACFEPKYASKVTQYVKQIRSKQKESLLHCNRLRRIQDENGSLELQIIICPEKSMTANEIGKDFEDLGIVSKMIFLYAVPAFPPLTDEQFHEWNSVWPVSYRKHVQRQDVFTVHELKRIESILEDLINAAGASHKHGEIGCAAAIYDPTTDTVLAVSVDERSKLKNPINHCVMNAINLVAKRELSRRQNRTDGSKDRYLCKDLTVVMTHEPCVMCSMGLLHSRIRRLIYCKKQPLTGGIESLYGIHWRAELNHRYLAYSGWNKPVPSIKENIHV
The following text describes a protein:
Function:
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization. FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion. Plays a critical role in sperm-oolemma binding prior to plasma membrane fusion. Can mediate cell-cell fusion in cultured mammalian cells independently of its binding to IZUMO1R/JUNO (By similarity).
Miscellaneous:
MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes). During the acrosome reaction, translocates to the plasma membrane.
Domain:
The extracellular domain assumes a distinct boomerang shape when not bound to IZUMO1R/JUNO. Interaction with IZUMO1R/JUNO triggers a conformation change, so that the IZUMO1 extracellular domain assumes an upright conformation; The cytoplasmic C-terminus region is not essential for fertilization. It is however required for protein stability.
Sequence:
MGPHFTLLCAALAGCLLPAEGCVICDPSVVLALKSLEKDYLPGHLDAKHHKAMMERVENAVKDFQELSLNEDAYMGVVDEATLQKGSWSLLKDLKRITDSDVKGDLFVKELFWMLHLQKETFATYVARFQKEAYCPNKCGVMLQTLIWCKNCKKEVHACRKSYDCGERNVEVPQMEDMILDCELNWHQASEGLTDYSFYRVWGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLPKMIKEEKPSPNIVTPGEATTESSISLQPLQPEKMLASRLLGLLICGSLALITGLTFAIFRRRKVIDFIKSSLFGLGSGAAEQTQVPKEKATDSRQQ
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses to esters. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLSQFFPHIKEKPLSERVKSRDAFVYLDRVMWSFGWTVPENKRWDLHYKLWSTFVTLLIFILLPISVSVEYIQRFKTFSAGEFLSSIQIGVNMYGSSFKSYLTMMGYKKRQEAKMSLDELDKRCVCDEERTIVHRHVALGNFCYIFYHIAYTSFLISNFLSFIMKRIHAWRMYFPYVDPEKQFYISSIAEVILRGWAVFMDLCTDVCPLISMVIARCHITLLKQRLRNLRSEPGRTEDEYLKELADCVRDHRLILDYVDALRSVFSGTIFVQFLLIGIVLGLSMINIMFFSTLSTGVAVVLFMSCVSMQTFPFCYLCNMIMDDCQEMADSLFQSDWTSADRRYKSTLVYFLHNLQQPIILTAGGVFPISMQTNLNMVKLAFTVVTIVKQFNLAEKFQ
The following text describes a protein:
Function:
Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Note=Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes.
Sequence:
MSGFFTSLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGTTTAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGLFFINGKYWAEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPHYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIFCSFIIFGSDYISEQSWWAILLVVLMVLLISTLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFGYGIWNSTLEISAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPTEDKGFYYQQMSDAKANGRTSSKAKSKSKHKQNSEALIANDELDYSPE
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MTVSYTLKVANSRFGGFSKLLFRWKGSIYKLLYKEFIVFVVLYALLSIVYRRLLTEEQKRLYTKVAQYCNRSTDLIPMSFVLGFYVTLIVNRWWAQYTSIPLPDQLMCVISSNVHGKDERGRILRRTLVRYANLSAVLILRSVSTRVLKRFPTMDHVVEAGFMTQDERKQFESLYSDFNKYWIPCVWFTNLAAQARRDGRIRDDVALRLLMDELNLFRAKCSMLFHYDWISIPLVYTQVGDPSPAAVSWSIGHCSDCLPSLSPSVPMFPMQVVTIAVYSFFAFCLIGRQFLEPLEPGQEGDLDMYIPLSTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNKLIDRNLQVSLLSVDDMYQNLPPATKDKYWNESTAQPPYTIATAAETLKPSFLGSTFDMRMTEDMEQSQTVEASPNMARTQTPLLSRFLAAASPAISIKNFGRGGRATPHLRRARGDSTAHSEDPEAVGRIEEEETEDEESQRGSPRSPKASNGQKLPLIQVEAPSKESIDAEQPGAGEP
The following text describes a protein:
Function:
Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP.
Sequence:
MKFSISAPKQVQPILSFKNKPSIVNVNSFLHPREKVVFVMGATGSGKSRLAIDLAHGVPHHLLGVFDSEDGNLTATDFTLLASQEISTLSANNKLPIVAGGSNSYIEALANHSSGLLLNNYECCFIWVDVSLPVLNAFVSKRVDRMMEAGLLDEVRQVYDPKADYSVGIRRAIGVPELHEYLRYESLVDRATQRKMLDVAVRKIKQNTEILACRQLQKIQRLSKKWKPCMHHVDATEVFLKHNEEEADEAWENLVARPTKRIVDKFSNRHVMKNDSVEHCLTTIGAASYGGGSGSRAHNMI
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAAPFALRKIGVPPNSANLTEARRRVFDFFRAACRSIPTIMDIYNLQDVVAPSQLRYAISAQIRNNAHITDPKVIDLLIFKGMEELTDIVDHAKQRHHIIGQYVVGEGLVQNTGNKDQGKTDFLKNFYTSNYF
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAPSLYRSENVSLVQLFLPTESARATVAALGRLSTIQFRDLNPDVTPFQRSFVKEIRRLNETQRQLRYFHAEITSAGIPIKEGPSENTELINSSTVEEVMDQCNTLDSRIRQLADSSKSLNERYERLLQLRNVLIKTNAFFNQSNEGLVLSSLDESALHASHEDDDELAAPLMGSSAVELDTTTTPTTLSESGHPSIPIDFVAGVIPTAKFQYLERILWRTLRGNLYIYHVPADLPTGSNDDGLADAQTIFLVFAHGTQILSKIRKISDSLGSTLFTVEDNAARRLDQLRDVNDRIGDLSSVLDNMKNALFTELSFVADHLSHWETLLHTDKCVYQAMNLFIFDQNHKCLIAEGWCPQDNLPLVQASLRDVSQRLGSQAPTILNVLETSEVPPTYHRTNKFTEGFQSIIDSYGIASYREVNHGIVAIVTFPFLFAIMFGDLGHGAIMFAIALAFILNEKKLGAKKDLDEMVGMVFFGRYILLLMGAFSMYTGFLYNDIFSKPLSLFTSGWHWPSKASGDLLRAVEVGTYPIGVDPAWHSADNNLLFMNSYKMKLSVIFGIVHMTFCLFLSLSNYRFFKKKLDIYAVFIPSLIFLESIFGYLVVTIIYKWSVDWNGLGLRAPGLLNMLILMFLSPGTIAEPLYPGQKYVQLILLGAALICVPWLLCAKPIALYRQHKKATAPKYLSLRDSDDTAEDANLLSSVTEADPKDHEDFELGEIVIHQVIHTIEFCLGCISHTASYLRLWALSLAHNQLSTVLWNMTIANGFRMTGVSGSIAIFILFAFWFVITCAVLVAMEGTSAMLHSLRLHWVEGMSKHFEGEGYAFTPFNFIENAE
The following text describes a protein:
Function:
Involved in cytoskeleton remodeling, which is needed for normal chemotactic aggregation and efficient cell sorting during multicellular morphogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MGGNLSSELKSTKYRKREIVDLRKMNIDKLPPTIGALQCKELLLSENDLITIPEEIGKLSKVEIIDFAKNRINYIPPEIGSLATLKQLFLSNNKLFYTPITPNIGALKNLTRLDLSSNQLDDLPVEISNCEALEYLDISDNQLQSFPLEFGKLYNLQVFNCSKNSLKSLPSEISGWVKLEELNVSNNQLAFLPNQICLLGLLSTLNVGFNKLQQLPEELSSMVSLTNLDLKVNPPLQYVPQLSNLRQLKILSIRNLQITHLPLGLGLLSELIELDIRDNPQLKEIPYDIATLINLQKLDLFGNNMRIVPREVGNLINLQTLDLRQNKLTIDNIPSEIGKLVNLKKLLLSNNLLIALPPEIASMKALKEFEASNNQLQAIPTEIGELSGLTKINLSGNKLTSIPASFGNLSELQICDLKSNEIAELPTTLDGLKSCTKIDLSHNMLTELPWEFGDLIGLTILDVGHNPLTIPPNPIVMKGTESIIQWLKKNEKEGRKGKVSGLGIQQDNEK
The following text describes a protein:
Function:
Probable phospholipase that hydrolyzes phosphatidic acid.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRFTHRGLPSSTRFRNIFVRLNHIYVPWFYAIDVPNSKPYLPTYQTLHSPKKFKPFSVDDSNRLEKASKRQERRPVLVNEDYLFKVDLSHMELSPTYWEGPTYQVRRGVWFDSSNQPLSSDLTSEIEGLYKQLKFDDSNDDPTTTPPAESQDIFRLKGKYPVDKENEGEQKNGSSNKDENESTFKFILFANKQTAFLLSDLDGGKLQLAFLRSNLAQSLPINATMITRSYKYSSSATTKQTSTSFKAAKTPQTEVADGSNSSKSRSIETKLEKKVSNLFNLSDFLQLFNGNASKDQDDAQSLEKQMETDYNNADNSQGANASSKIEDGKNSGASDRQIRSNRRDVDNLILCVHGIGQTLGKKYEYVNFAHTVNLLRSNMKKIYNNSEKLQSLNTAPDYKSNCNVQVLPITWRHSISFQTDAKEENIENPDLPTLSQVTVNGVLPLRKLLADGLLDILLYVEPYYQDMILQQVTSQLNKTYRIFKEFNPEFDGKVHLVGHSLGSMILFDILSKQKKYELEFQVDNLFFIGSPIGLLKLIQRTKIGDRPEFPNDLERKLTVQRPQCKDIYNVYHVCDPISYRMEPLVSKEMAHYEQTYLPHCSEAYGLTSKVLEFGENIWKDLPGTDENNLQSKKTSPEKKEVKLSENLTRMLTGLNYTGRLDYAMSPSLLEVDFISAIKSHVSYFEEPDIAAFILKEILSKHENASEIYVKRKTG
The following text describes a protein:
Function:
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.
Domain:
The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.
Sequence:
MDKEKLDVKIEYCNYAMDSSVENMYVNKVWVQCENENCLKWRLLSSEDSAKVDHDEPWYCFMNTDSRYNNCSISEEDFPEESQLHQCGFKIVYSQLPLGSLVLVKLQNWPSWPGILCPDRFKGKYVTYDPDGNVEEYHIEFLGDPHSRSWIKATFVGHYSITLKPEKCKNKKKWYKSALQEACLLYGYSHEQRLEMCCLSKLQDKSETHDKVAALVKKRKQTSKNNIEKKKPKFRKRKRKAILKCSFENVYSDDALSKENRVVCETEVLLKELEQMLQQALQPTATPDESEEGHGEEINMGEKLSKCSPEAPAGSLFENHYEEDYLVIDGIKLKAGECIEDITNKFKEIDALMSEF
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MTRQNWVKIPIKPTDYESKLGRIANHKTISEYSVIMYHSPTEEREIRNDLTNVRYLIDDDVRDSLLPFDLKLGLKTFQDKQIEGETLRKEPCLQTLCNWAIKQPGSTINEVFDGADFVTWRGTLKRIAATIHKKDTWRFVAVSLGGVIFISEQAREYHGGRHHLPTYSGFKFEQYITTNRDGDLDSDEPVDNRSTFELKTGRDVKNFGKLETVLQSEIVGVKSLIMGIKGENYMVERVEETSIDQIKAKNGQIARKTSQSYAFLADFLSRLKAFLGDHEACESYFDSKKMEVVIKRISLEEANRNGKGVTAEFMKYFNQ
The following text describes a protein:
Function:
Serine/threonine protein kinase shown to have protein phosphorylation activity in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 10200 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTASSSASQLQQRLPEEKPWPQLSGSNADAQTFKCKYVTNHNSLGDGNFSVVKECMNIHTKDLYAMKLIKKQTVKNKIQLIQREFDLLRSISEKIRDMEKKNEHSLDIFEGHHHILQLFDYFETADNIVLITQLCQKGDLYEKIVENQCLDLETQVTSYCACLVSVLEFLHSQGIVHRDLKAENVLFRLRVNENEKNLQGEHHGDFKYDLLAHDLVLADFGLAAEYNTSKVNSLKEFVGTISYIAPEIVKCKGVGEMTPDQVGKLDKYGCPVDIWALGVLTYFMAFGYTPFDCTTDDETLECISKCDYYVDEQMMHDPKYEQFWNFVQCCFTIDPAVRRSAKNLKQHPFIKDYFATSNSLNTKDTPNFSFHPTIRRVSSTASMHTLRSPSKSRKTTTLAYLNMDGGSSETSTAFSSKMDLPDLYVDRTINSRERSLNRIRDTLKKTLSMTSLKPAGTFDYLHANKNGTSLSSSKSGLVKKNSTFVLDPKPPKNSLMNGCFSTTPESRSNFNTPKTLSRQGSSTSVKKYVNEVDLLLTPRTASMSSNDTTAINDYDTTNDKNPARKHAASFQVNVDDSDGDETMQI
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEIKKDKNVLNKVNGFMDKVYDTPEIFVGSTNKVKDSMTDIMSNLYQLAKKNETIVTETETDALESLVTKDFDSEQIWAQIQLYNDPVLSELESKINGFVKSKENIEILSQSNKKSNKRSIQYDEDLEDDYQDSELDTDEGLDGEEDLDGDEDLEDDEDLQDDENLDDDDDDLQDDEDLEDEDEDAQDLEEEDSLDEGIDSDSTKSSKSSKSSKSTKSITKNNNKKNNNKNIDFFDAKEMEKFLDDEDDNEYQRREDEDKDDEDDFEGDSEEEDGGLDLPDAELDDEERELDALLDKYMEQNEMEQGESSNKKSNKKNKAKDVADMKFDDFFADPDEQDEDNEDDFGLDHEDEEEEYQDDEDEEQDQLSAEEDGEEVDEKVESEPEEATLPEEELSAFQKKASRIQERIKKLEQENLKKKDWTMIGETSAKERPSDSLLGESLDYEHTQRAAPNVTEETNKSIEDIIKKRILEKNFDDVIRKTEKEFKDNYKKKVEISDEKSQEGLGDIYEKTYMKQVLGVEETDELKQKHIKIFELFNKLCYKLDSLTNFQYTPKMIKNKELNITTASAVTMEEKVPVATSTSTMIAPEEVYFKKNADEKGDSEKTKEDRVKERKQIKKTWKNEKEEKEAEERHKEKVDPNYAKRNTVAKDIAHLKQAKNVTIVDTSKSQVKSGDTRSGAFFKTIQTSEENRKKGIEDPNSLKSKKKQKFDALSFKTI
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MRLIHLSDIHAGKNLGRVSRNEDVVYALNQVVDFCKENKPDLVLVAGDVFDKANPDNEAKEIIFDFFLKLHSLNIPSVVISGNHDSYEFMKSLKKLLQVIDVYVVPKPNLEECVLDVKGLKIACLPYPSERVLTRAGEDSKLSYAVLVEKAIKYLYEKVKDAPLKVLLSHLFIAGSKYTRTEREATITDYYAVEPSAIPEGFDYVALGHVHRYQRIEKAPTHVYYTGSLFQLDFSEAGQEKFFNFVELKEGEPPHVEAIKLSLKNPLHTFEINQENYAKELEKIKDVQGYIKVHLIVKDKTKMHLVAEKVKEALGEKLIKLELLTPEEAIKKRLEEEREIQKLNLLDLYRDYFKESYGREVPQEIIKTVSQLLEQVHES
The following text describes a protein:
Function:
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
Miscellaneous:
MISCELLANEOUS: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
Sequence:
MERFKKASSIIETLKQQGHEAYFVGGSVRDLIIDRPIGDIDIATSALPEEVMAIFPRNVPVGLEHGTVIVVENGEPYEVTTFRTESEYEDFRRPSSVQFVRSLEEDLKRRDFTMNAIAMTEEGKMVDLFAGQEAIQQREIVTVGNAADRFQEDALRMMRGIRFVSTLGFSLEMKTKQAIETYGHLLEHIAIERITVEFEKLLTGTYCVKGLKELVETKLFSHLPYLQMSEERLLKATQYKWDSFETDIEAWAFFLYCIGEEHPSVFLRQWKFSNKKIKDIVAVLLTIRTRKEKDWDTVLLYKTGIHIAEMAERVYEAMIERYDPTSVERVQSMFHALPIQERQEMNVTGNDLLNWANKKPGPWVAEMLQKIEEAIVQGNVVNEKERIREWLQGCNLL
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex.
Sequence:
MVFRFLGNNNNNNNELPDQQLINEIGYLSNFSNEQLEQLLDIIFEFMIIQKSEQLLNQIQEFSNEHSINENTLKNIIRGCIIFFKSSAKNNLTIDHLREDCIQFKLDEEQSKLVSTKYKQHYIEISRSLVGNSLTINQVLDMQWRFGVTTSSSEFTKSNTTGSTFLQLKLVLDKGNNIKEDVHMELTLPQFYEFLKEMQSAKASLEYFN
The following text describes a protein:
Function:
Auxiliary subunit of the NALCN sodium channel complex. The NALCN sodium channel complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability. Activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTKAEQFASKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSILSRTGKKENQDASNLTVPMTMCLFPVPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSERGPQSRDAQLSDYPSLDYQGLYVTLVTLLDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDVLSTLPYTMISTLATFPPFLHKDIIEYLSTSFLPMAILGSSGREGVPAHVNLSASSMLMIAMQYTSNPVYHCQLLECLMKYKQEVWKDLLYVIAYGPSQVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWNPIHCQHIECHNAINKPAVKMCIDPSLSVALGDKPPPLYLCEECSERISGDHSEWLIDVLLPQAEISAICQKKNCSSHVRRAVVTCFSAGCCGRHGNRPVRYCKRCHSNHHSNEVGATAETHLYQTSPPPINTRECGAEELVCAVEAVISLLKEAEFHAEQREHELNRRRQLGLSSSHHSLDNTDFDNKDDDKHDQRLLSQFGIWFLVSLCTPSENTPTESLARLVAMVFQWFHSTAYMMDDEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCLLPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVISQSVWECIMPEWLEAIRTEVPDNQLKEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSTVQEQALLWLHVLSELDITVPLQLLISMFSDGVNSVKELANQRKSRANELAGNLASRRVSVASDPGRRGQHNTLSPFHSPFQSPFRSPMRSPFRSPFKNFGHPGGRTIDFDCEDDDMNLNCFILMFDLLLKQMELQDDGITMGLEHSLSKDIISIINNVFQAPWGGSHSCQKDKKATECNLCQSSILCYQLACELLERLAPKEESRLVEPTDSLEDSLLSSRPEFILGPEGEEEENPAAKHGENPGNRTVPSEHAAIKNDTERKFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNCLKILCLHGECLYTARKDHPQFLAYIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADIFWTIINGNFNSKDWKMRFEAVEKVAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLDFQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLDCNKEFPFPTTITAVRTNVANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPAESKRALSLPETLTSKIRQQSPENDNTIKDLLPEDAGIDHQTVHQLITVLMKFMARDESSAESDISSAKAFNTVKRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCPQLRHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDVSKTLLHLIHITVNTLNAQYHSCKPHATAGPLYTDNSNISRYSEKEKGEIELAEYRETGALQDSVLHCVREESIQKKKLRSLKQKSLDIGNADSLLFTLDEHRRKSCIDRCDIDKPPAQAAYISQRQNDHHGRSRQNSATRPDNTEIPKNPGTEGFQEIRRPVIPEVRLNCMETFEVRVDSPGKPAPREDLDLIDLSSDSTSGPEKHSILSTSDSDSLVFEPLPPLRIVESDEEEEMMNQGNGGALGNNAASSPSIPSQPSVLSLSTTPLVQVSVEDCSKDFSSKDSGNHQSASNEDSTIAALDDLTDSEELSKSEELREFASGSPLTLKQKRDLLQKSSAVPEMSVDYNPEPSPAEEKPGQTPTSGVKTVLLKVPEDGENLIESEKPNTSAESDTEQNPERKVEEDGAEESEFKIQIVPRQRKQRKIAVSAIQREYLDISFNILDKLGEQKDPDPSAKGLSTLEMPRESSSAPTLEAGAPETSSHSSISKQIQPGKRQCNVPMCLNPDLEGQPLRTRGATKSSLLSAPSIASMFVPAPEEFTEEQPTVMADKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDLAAPLLLDIMQSVGRLASSTTFSNQAESMMVPGNAAGVAKQFLRCIFHQLAPNGIFPQLFQSAIKDGTFLRTLATSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCLENIATFMEALPMDSPSSLWTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLKIPSTNATRSLLEPFSKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKSPLPDTNLLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAAMECIRQYVSEVLEFMADMHTLTKLKSHMKTCSQPLHEDTFGGHLKVGLAQIAAMEISRGNHRDNKAVIRYLPWLYHPPSAMQQGPKEFIECVSHIRLLSWLLLGSLTHNAVCPNASSPCLPIPLDAGSHIADHLIVILIGFPEQSKTCVLHMCSLFHAFIFAQLWTVYCEQSAVATNVQNQNEFSFTAILTALEFWSRVTPSILQLMAHNKVMVEMVCLHVISLMEALQECNSTIFVKLIPMWLPMIQSNTKHLSAGLQLRLQAIQNNVNHHSLRTLPGSGQSSAGLAALRKWLQCTQFKMAQVEIQSSEAASQFYPL
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDGLKITFSKKEKIFLAVFISLYVLVAVLNIQQLKRTPMEEIFGGLGKRWIVDINGFRINPMTIIVGTAIAIFLIVLAYRLRKFEMIPNRKQAFMESILEMFYEIVDESIPDKRFVKPTFVVATTLFLFITISNIIGGAVPGVSVVADETGAVQKVVLFNDTWPAPTGDLNTNLTYAVMVLIISHAFAIKSKGFKEWLKSWFYPNPVMFPINLIGELAKPISHSLRLFGNIGGGAILVYILSYMTKYFFAPIIFWGFFGIFVGLVQAFVFSMLAVAYISSQLS