lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with methyltransferase trm7, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLSVIKAASLDLESLPSQPTVSSFQQLRETFIQSKSEDWYLKNGLFFRYYSFLKSSLENATLDGPSQVACLDTISVWLRRIFNACKQDPEISKYVWDTMELKFWTNLFSLPANKISIPGLTGVQVAVKDVFSKSLQLYLLVCPSEDIKNDFLLDSLKHALHWDRHAKVVCTAIQLLVKVTGAEAVFAFQPDFFEQSLKLLKDYSYAQAISSTILTVLTLRFKSLSEETEDREEVETKWMNIWCPIILYEFYGNDRQVQAGMSSFLIPSLLGVSPGITVKFLSRLQNYPNVSKDARDAACLYALKIAKDSKIIKNLDLVKEHAFVKTLFKHPDIKIQLACFRLIALCPNVSSPLSFEDFDCLESNIEFSFNVLDPDSRQILLKSMQDFFIRLRASCHSIARTMRSRHSDKVALSGLLDRAMQFLTSFISVCKKHLYPTCNYQQVLVSLSFLDTLISFGLDDNVESSSIREAQHDFPFSMVIIDRDLSRLMIDRLKDPYDDIRNLCLKILLSYKSLPGFISDSDAYFLFNHGLELLNAVRSHECDGGAKTIYLCNHFMEKSVPGSVLANTKVILNRLKSNIEHAKTSLLEAAVNCPLQGYLIQLTYIFQSLSPTIVKNDNESWKNIVMELIKASETIWGLIKDVLCDDSPEGNLPDGEGEGGIVSNLEDTPAQLILSYSWRSLKETSSLLTVLLTKCLSLFDEEFTPFTLNYYGELMMTWLWEIRHRGAFTSVYPCFIEYCSFLFECNKHEISELPDPWLHKNLSVIQEKSSFITRRSGGIPLSITAILVAGKDKREQLIEQTVISLISIAKQPVEQKNIAGQFDLPQVHAMNTLKTIFTEHRLSSVSVEYLEPAIALSIEGFSHELWPIRNCSVMLFTALINRAFGSKKPKDAVNLGNNKGLSTKMFFSKFPTLHDYLLRELEVSVASLSSNDQPSTGLYPILNMFSRLQYAQPYGNENEWTGLSQFEPLIFKCTASRICKVREIASLSLTCLLDCSKMTTFIVSQLKGVAGLQQNEIHGKLLTIRAVLSCFFSKLTLQQVQEFYEVVPLAFINCFLEFTSSKTSFYAKKLFLEVLNSYFMSNTDSNAKRLQQLRRMTMDYCKRMLLDRKANVTNVFNTIGLPIHQQMAATIFLENLKEFSVYCDAHSIGFLVSKLLHYEFYEVQLTTLRSIVDSPRKKIIVNNPEILQALIKLTPRNQWSQVRALALSLLSDSLNSTSYRLLGISCSDMVSNILSNECLPIKESFIVLLGSCIKQLKTENFLEYKVTFAKWVEILLSYSNEYQPFSSRKAALDSIIHFDLFNAESTAEAFSFEFYILYLLLGDFLNDDDEEIRSLAANHAYQVLGTSAQCVTEIWNLWKLRTKATFGGQHDFQHCINKRLILEDGCELASVQLDNALSRNCSLFERERQNLYYSDNQKLEDLLFYASYPNEKLKDWATDGINAILSRFEDVSRDGPLGKTSDPNVWFTIYKIIRIAEHVHLPLDRVHSLMNRIDGHPSFCQ
The following text describes a protein:
Function:
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs involved in chromosome segregation, splicing and transcriptional regulation; appears to bind transcripts both co- and post-transcriptionally and binding might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face. Plays a role in telomere length maintenance and transcription elongation regulation.
Miscellaneous:
MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to the 5' region of active genes transcribed by RNAPII.
Domain:
The RxxxRR motif forms an adapter helix that bridges the nucleosome acidic patch and ubiquitin from ubiquitinated histone H2B which is critical for COMPASS activity.
Sequence:
MSNYYRRAHASSGSYRQPQEQPQYSRSGHYQYSNGHSHQQYSSQYNQRRRYNHNDGTRRRYNDDRPHSSNNASTRQYYATNNSQSGPYVNKKSDISSRRGMSQSRYSNSNVHNTLASSSGSLPTESALLLQQRPPSVLRYNTDNLKSKFHYFDPIKGEFFNKDKMLSWKATDKEFSETGYYVVKELQDGQFKFKIKHRHPEIKASDPRNENGIMTSGKVATHRKCRNSLILLPRISYDRYSLGPPPSCEIVVYPAQDSTTTNIQDISIKNYFKKYGEISHFEAFNDPNSALPLHVYLIKYASSDGKINDAAKAAFSAVRKHESSGCFIMGFKFEVILNKHSILNNIISKFVEINVKKLQKLQENLKKAKEKEAENEKAKELQGKDITLPKEPKVDTLSHSSGSEKRIPYDLLGVVNNRPVLHVSKIFVAKHRFCVEDFKYKLRGYRCAKFIDHPTGIYIIFNDIAHAQTCSNAESGNLTIMSRSRRIPILIKFHLILPRFQNRTRFNKSSSSSNSTNVPIKYESKEEFIEATAKQILKDLEKTLHVDIKKRLIGPTVFDALDHANFPELLAKRELKEKEKRQQIASKIAEDELKRKEEAKRDFDLFGLYGGYAKSNKRNLKRHNSLALDHTSLKRKKLSNGIKPMAHLLNEETDSKETTPLNDEGITRVSKEHDEEDENMTSSSSEEEEEEAPDKKFKSESEPTTPESDHLHGIKPLVPDQNGSSDVLDASSMYKPTATEIPEPVYPPEEYDLKYSQTLSSMDLQNAIKDEEDMLILKQLLSTYTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGFRKIADKLKINYLPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSSRDNRASNRRFQQDIEAQKAAIGTESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFLN
The following text describes a protein:
Function:
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGS
The following text describes a protein:
Function:
Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation. Activates the transcription of FLNC.
Subcellular Localization:
Nucleus.
Sequence:
MENQEGTVWQQQVVTEESQEAGTQQAQYLQQLHTMEAGQTQQYTTADGSTIAVSFAPGVTYEQAQQAVESHVTNTQAAQGQATVTAVSVSDISDEGVEENGEAKTQQQQTITLAVAPDGQVQQVEQQQTIAIAVDAVAAQVQHVVQQQQAMEVAIDPSMTAGQEQQENVSADQWRAGPGAGDLGEGGQQGHVAMKDEVDEEAMDTTPFEDEPEDLWGGPVQRIPSKPVLSKARASLPNQLFLAKSGETTEHGVFTKRALPKRTQFGPVEAKLLKKEEIPEGTFLLKLQHKTEGEEQPDDQPELYYDLTNEDECDWMMFVKPAANHMEQNLVAYQHGNEIFYTTIKPVEPRQELKVWYSTSYASFMGVSVHEVTEEEKEAMREREATWPCFECPRKFMSSEQLQRHLAIHEKVITVRRRRWGKGRRGRRRKVPAGDRDNLECDTCHKVFLRAYSLQRHLVMHSGEKKFNCPVCKKMFSHDYNRTRHLRKHQDRGEGLEIVNQLLEGKSPSESTSEARDEPEEGEWSCRHCVLVFENAELLRLHVQSHPAEELDEDELESEDDWDSDEDEDDVDENTVKTDANDSQDGSSEQPRESALGKNFPCDVCDKSLGSKQALKYHMRRHEERGEVEMQCPDPECEKSFQQKRDLVTHSTVHGKAKSAHGMVTRRALSLYKCDQCGKAFRDSEKLDKHLLLHVNEEDRPIVCEICNKRFLNNSAIACHMKTHSGKKYYACPFCNEGFDRTETLREHVPVHAVDGVYSCPTCSKTFPEFVQVRKHIRSFHSDKMYQCQVCEKAFPRPDKLKLHMLKHSDRRDFLCANCGKQFKRKDKLKEHMLRMHNPEREARNANRPNKPKAFKPKTPPSDYNSFTFKCRGCMLGFRRRGMLVNHLAKRHPETRPESIPELALPIIKPNRDYFCQYCEKVYKSSSKRKAHILKNHPGAELPPSIRKLRRNPQDISINTHTGTAGTIASAPVCCPHCPKQYSSKAKMTQHIRKKHAELVGTAIPMPAPTVPITPAAQQAIAEAAAADLTYKVIVRYDAPPNEPSEEAVLEHIPQHMVVQAPPQDANVARQTVQRFTVETTGQAIPVPSETMQAADLLTQAMSELSQTLSEYRPQPGEYQTIAAHRVVTTQPTGELVHHQVVPVSIQTADQSQGTVTVDVSQIRQSPTHFQQQALTIQQPISPAPTPPQQQVQQVQQVQQVQQVQQVQQVQQVQQAVQAVQTVVSTTEQVAVTHPIAVSTQAQPQQFIARPWPGTFTGNVTYQ
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity). Binds GTP with specificity. Plays a role in the root morphogenesis by regulation of the cell proliferation.
Miscellaneous:
MISCELLANEOUS: Dark-grown xlg1-1 xlg2-1 xlg3-1 triple mutant plants showed markedly increased primary root length compared with wild-type plants. Dark-grown roots of the xlg triple mutants also showed altered sensitivity to sugars, abscisic acid (ABA) hyposensitivity and ethylene hypersensitivity, whereas seed germination in xlg triple mutants was hypersensitive to osmotic stress and ABA.
Subcellular Localization:
Nucleus.
Domain:
The helical domain (514-664) is required for self-activation.
Sequence:
MPLKEDDCCLFAEEYDGPPLSYNIPCAVPINVEKIPVAAVVSPVCISDNMSFPVIQPILSVESKKFLIDSVSPTSVIANCGSNQLELVSDSITVSPTSVIEHTEEEEEEEGGDGEDCELSSSGELLLRSCSVKESLDLNESSSNPLVPDWESNESVLSMDYPSSRVTGDCVSETNGDGKKQPVVTFLGIASDDGFEEEESCSNLRRVRVVPVKKQPQTKGKKGSCYRCFKGSRFTEKEVCLVCDAKYCNSCVLRAMGSMPEGRKCVTCIGFPIDESKRGSLGKCSRMLKRLLNDLEVKQIMKTERFCEANQLPAEYVYVNGQPLYPEELVTLQTCSNPPKKLKPGDYWYDKVSGLWGKEGEKPYQIISPHLNVGGPISPEASNGNTQVFINGREITKVELRMLQLAGVQCAGNPHFWVNEDGSYQEEGQKNTKGYIWGKAGTKLLCAVLSLPVPSKSTANASGEQLYSANSRSILDHLEHRTLQKILLVGNSGSGTSTIFKQAKILYKDVPFLEDERENIKVIIQTNVYGYLGMLLEGRERFEEEALALRNTKQCVLENIPADEGDAKSNDKTVTMYSIGPRLKAFSDWLLKTMAAGNLGVIFPAASREYAPLVEELWRDAAIQATYKRRSELGLLPSVASYFLERAIDVLTPDYEPSDLDILYAEGVTSSSGLACLDFSFPQTASEENLDPSDHHDSLLRYQLIRVPSRGLGENCKWIDMFEDVGMVVFVVSMSDYDQVSEDGTNKMLLTKKLFESIITHPIFENMDFLLILNKYDLLEEKVERVPLARCEWFQDFNPVVSRHRGSNNGNPTLGQLAFHFMAVKFKRFYSSLTGKKLFVSSSKSLDPNSVDSSLKLAMEILKWSEERTNICMSEYSMYSTEPSSFSN
The following text describes a protein:
Function:
Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.
Sequence:
MREISVPAPFTVGEHDNVAAMVFEHERDDPDYVIYQRLIDGVWTDVTCAEAANQIRAAALGLISLGVQAGDRVVIFSATRYEWAILDFAILAVGAVTVPTYETSSAEQVRWVLQDSEAVVLFAETDSHATMVAELSGSVPALREVLQIAGSGPNALDRLTEAGASVDPAELTARLAALRSTDPATLIYTSGTTGRPKGCQLTQSNLVHEIKGARAYHPTLLRKGERLLVFLPLAHVLARAISMAAFHSKVTVGFTSDIKNLLPMLAVFKPTVVVSVPRVFEKVYNTAEQNAANAGKGRIFAIAAQTAVDWSEACDRGGPGLLLRAKHAVFDRLVYRKLRAALGGNCRAAVSGGAPLGARLGHFYRGAGLTIYEGYGLSGTSGGVAISQFNDLKIGTVGKPVPGNSLRIADDGELLVRGGVVFSGYWRNEQATTEAFTDGWFKTGDLGAVDEDGFLTITGRKKEIIVTAGGKNVAPAVLEDQLRAHPLISQAVVVGDAKPFIGALITIDPEAFEGWKQRNSKTAGASVGDLATDPDLIAEIDAAVKQANLAVSHAESIRKFRILPVDFTEDTGELTPTMKVKRKVVAEKFASDIEAIYNKE
The following text describes a protein:
Function:
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Sequence:
MSDQPAATLGILGGGQLAQMLALAALPLGVQVRVLEPDAEAPARLCAEHVHAPYTDPAGLDALAACDAVTLEFENVPVESLDALRGRVPVRPGAGLLARSKHRAREKAALQEAGARTAPFVVIQREADLDGALDRVGGQGILKTSELGYDGKGQVRVASDTDLRQGWAELGQVACILEGFVTFEREVSLAVARTADGRLAFGPLVENVHRDGILRTSVYPAAVPDGTEARAREMARAVAEGWGLEGLLTLEFFQVPDGDLLVNEVAPRVHNSGHLTQDGGGASQFEAQVRAVLGLPLSDWSPLLPCAMVNYVGVEGAAPDWAAIDALPGTRVHLYHKAHRTGRKLGHVNLAAPDLPTLHQRLAQLEQLIP
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGFYEILSTMVPLYLAMLLAFASVKWWRMFSDEQCSGINKFVANFAAPLLSFKIIYSNDPYKMNHKLILADTMQKLLILFALMLWVKLTKRGSFDWMITLFSMSTLPNTVILGIPLLRAMYGEESEQILFQIVVLQFVVWYPFLLFLYELREAKGAVGRRVSTAVINGSTVVLEVEARSETRMSSLSLATVDGQGSTTAMNGSVVLVVEASAKENSLGYLNGEEGTANSKEREVQVEAAPPQMRMINLLILVWSKVIKNPNTYSSILGLVWGLISFRFNIRMPKIVDKSVTILSVTGLGLSMFSLGLFMASQPNLMPCGKRNATIAMFVRFSFSVVVMSMCSILLGLQGNLLKVAIVQFCNPSYASYAVFRLVGSTGKK
The following text describes a protein:
Function:
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Miscellaneous:
MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.
Subcellular Localization:
Secreted.
Sequence:
MRLFLSLPVLVVVLSMVLEGPAPAQGAPDVSSALDKLKEFGNTLEDKAWEVINRIKQSEFPAKTRDWFSETFRKVKEKLKINS
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MDAKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDASRTIVRNVKGPVRENDILCLMESEREARRLR
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSHSHLSFAFGVLGNIASFVCFLAPLPTFYRVCKKKSTEGFQSIPYVAALFSAMLWIFYAYVKTGEMLLITINAFGCVIETIYLAVFITYCPKKARGRVKLLGWICVVFATSVFAAPLSIIRVVIRTKSVEFLPFPLSLLLLISAIMWLLYGISLKDIYVTLPNVVGLTFGVIQIGLYAMYRNNKPVKDQKLPEHKGDIVDNNNESVIAPTVNGEKQEQEVKPQGGIIETGEKKEENNKQDQQQPEENKKFDQVVHEQTKLNNKNTNNINDDDNNKTGERVISCEV
The following text describes a protein:
Function:
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Inhibits phagocytosis (By similarity). Plays a role in podosome formation.
Subcellular Localization:
Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.
Domain:
The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
Sequence:
MAEGKAGGAAGLFAKQMQKKFSRAQEKVLQKLGKTVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEVYSSDWDGHEDLKAIVGNNDLLWEDYEEKLADQALRTMENYVSQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDDAKMAKAEEDFSKAQIVFEDLNQELLEELPILYNSRIGCYVTVFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVQSCAASSPVSPVSPVSPVTSPTSPSATSEPESVSATGEELTSEAGGEDSCESQESLKDEEADEAQSETSSSLPACNGPTPAPASPAAEVGSQEEALSSSAQSPGRGQTGKDTPSPGDVVLRARASSEGAEQSKRAASIQRTSAPPSRPPPPRASGSGSCNAPGSPEGSSQLCSPRASPDASSNPEPAETREKEGAGSSGPEEPRAVSTKSATQASGGLVGLFL
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MKINDLKPAPGSKKKAKRIGRGLGSGHGRYATKGLKGQKSRSGGAKGAGFEGGQMPLQRRVPKRGFSNAPFKKEYAIVNLEDLNKIIDEVDIITPETLLQKGIVKDLKDGLKILGNGEIKKSITVKTNAISKSALQKIQSVGGKVEVI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro. Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome.
Sequence:
MFYIIGGITVSVVAFFFTIKFLFELAARVVSFLQHEDRERRGERTIYDYVRGNYLDPRSCKVFWDWKDPCEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHICHVELAMDIPVTQEVLQEPSSNVVKVAFTVRKAGRYEISVKLGGLNVAYSPYYKVFQPGTVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTSNSVSLIDEHNYSLSIHEGPQEEEPSDVLFEKSVLSNQQTCQVFLRLTLLRRGCFRACISYQNQPISNGEFDIIVLSENEKNIVERNVSTSGVSIYFEAYLYNASSYANTQWHLPPLHLGSSQRRPSTATEDEDEDSPSDSQTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLFTFRVCPGTKFSYHGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFHRELRQVHMKRPHSKVTLKVSRHNLLESSLKASRNFSVSDWSKNFEVIFQDEEALDWGGPRREWFELICKVLFDTSNQLFTRFSDNNQALVHPNPNRPPYLRLKVYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMNYKYFETDDPEFYKSKVCFILNNDVSEMELVFAEEKYSKSGQLEKVVELVAGGAQVPVTNENKILYLNLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELELLMCGTGDISVCDFKAHAVVVGGSWHFREKVMRWFWTVVSSFTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIASPTHSTLPTAHTCFNQLCLPTYDSYEEVHKMLQLAISEGCEGFGML
The following text describes a protein:
Function:
Catalyzes the dehydration of galactarate to form 5-dehydro-4-deoxy-D-glucarate (5-KDG).
Domain:
Consists of three domains. The N-terminal SAF domain, which forms a beta-clip fold, is likely involved in the substrate recognition. It is connected by a long unstructured linker to the second domain, which serves as a dimerization interface between two monomers. The C-terminal domain represents the catalytic core of the protein and probably contains the metal binding site.
Sequence:
MANIEIRQETPTAFYIKVHDTDNVAIIVNDNGLKAGTRFPDGLELIEHIPQGHKVALLDIPANGEIIRYGEVIGYAVRAIPRGSWIDESMVVLPEAPPLHTLPLATKVPEPLPPLEGYTFEGYRNADGSVGTKNLLGITTSVHCVAGVVDYVVKIIERDLLPKYPNVDGVVGLNHLYGCGVAINAPAAVVPIRTIHNISLNPNFGGEVMVIGLGCEKLQPERLLTGTDDVQAIPVESASIVSLQDEKHVGFQSMVEDILQIAERHLQKLNQRQRETCPASELVVGMQCGGSDAFSGVTANPAVGYASDLLVRCGATVMFSEVTEVRDAIHLLTPRAVNEEVGKRLLEEMEWYDNYLNMGKTDRSANPSPGNKKGGLANVVEKALGSIAKSGKSAIVEVLSPGQRPTKRGLIYAATPASDFVCGTQQVASGITVQVFTTGRGTPYGLMAVPVIKMATRTELANRWFDLMDINAGTIATGEETIEEVGWKLFHFILDVASGKKKTFSDQWGLHNQLAVFNPAPVT
The following text describes a protein:
Function:
Involved in the incorporation of salicylate into the siderophore pyochelin. Catalyzes the elimination of the enolpyruvyl side chain from isochorismate to yield salicylate and pyruvate via a rare pericyclic hydrogen transfer mechanism from C2 to C5. PchB also catalyzes the nonphysiological Claisen rearrangement of chorismate to prephenate in which the pyruvylenol tail is transferred from a C3 ether linkage to a C1-C9 linkage.
Sequence:
MKTPEDCTGLADIREAIDRIDLDIVQALGRRMDYVKAASRFKASEAAIPAPERVAAMLPERARWAEENGLDAPFVEGLFAQIIHWYIAEQIKYWRQTRGAA
The following text describes a protein:
Function:
Involved in the reduction of the double bond between C-4 and C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
Sequence:
MSPAEREFDIVLYGATGFSGKLTAEHLAHSGSTARIALAGRSSERLRGVRMMLGPNAADWPLILADASQPLTLEAMAARAQVVLTTVGPYTRYGLPLVAACAKAGTDYADLTGELMFCRNSIDLYHKQAADTGARIILACGFDSIPSDLNVYQLYRRSVEDGTGELCDTDLVLRSFSQRWVSGGSVATYSEAMRTASSDPEARRLVTDPYTLTTDRGAEPELGAQPDFLRRPGRDLAPELAGFWTGGFVQAPFNTRIVRRSNALQEWAYGRRFRYSETMSLGKSMAAPILAAAVTGTVAGTIGLGNKYFDRLPRRLVERVTPKPGTGPSRKTQERGHYTFETYTTTTTGARYRATFAHNVDAYKSTAVLLAQSGLALALDRDRLAELRGVLTPAAAMGDALLARLPGAGVVMGTTRLS
The following text describes a protein:
Function:
This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Sequence:
MKKAKAIFSLVVALMVLAIFCFAQNTGSTATTAAAAVDSNNDDWLHCKGNKIYDMYGNEVWLTGANWFGFNCSENCFHGAWYDVKTILTSIADRGINLLRIPISTELLYSWMIGKPNPVSSVTASNNPPYHVVNPDFYDPETDDVKNSMEIFDIIMGYCKELGIKVMIDIHSPDANNSGHNYELWYGKETSTCGVVTTKMWIDTLVWLADKYKNDDTIIAFDLKNEPHGKRGYTAEVPKLLAKWDNSTDENNWKYAAETCAKAILEVNPKVLIVIEGVEQYPKTEKGYTYDTPDIWGATGDASPWYSAWWGGNLRGVKDYPIDLGPLNSQIVYSPHDYGPSVYAQPWFEKDFTMQTLLDDYWYDTWAYIHDQGIAPILIGEWGGHMDGGKNQKWMTLLRDYIVQNRIHHTFWCINPNSGDTGGLLGNDWSTWDEAKYALLKPALWQTKDGKFIGLDHKIPLGSKGISLGEYYGTPQASDPPATPTATPTKPAASSTPSFIYGDINSDGNVNSTDLGILKRIIVKNPPASANMDAADVNADGKVNSTDYTVLKRYLLRSIDKLPHTT
The following text describes a protein:
Function:
Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
Sequence:
MSLRVRQIDRREWLLAQTATECQRHGREATLEYPTRQGMWVRLSDAEKRWSAWIKPGDWLEHVSPALAGAAVSAGAEHLVVPWLAATERPFELPVPHLSCRRLCVENPVPGSALPEGKLLHIMSDRGGLWFEHLPELPAVGGGRPKMLRWPLRFVIGSSDTQRSLLGRIGIGDVLLIRTSRAEVYCYAKKLGHFNRVEGGIIVETLDIQHIEEENNTTETAETLPGLNQLPVKLEFVLYRKNVTLAELEAMGQQQLLSLPTNAELNVEIMANGVLLGNGELVQMNDTLGVEIHEWLSESGNGE
The following text describes a protein:
Function:
Potential calcium sensor that binds calcium in vitro.
Sequence:
MTLAKNQKSSLSRLYKKVSSKRSESSRNLEDESRTSSNSSGSSSLNVNELRTVFDYMDANSDGKISGEELQSCVSLLGGALSSREVEEVVKTSDVDGDGFIDFEEFLKLMEGEDGSDEERRKELKEAFGMYVMEGEEFITAASLRRTLSRLGESCTVDACKVMIRGFDQNDDGVLSFDEFVLMMR
The following text describes a protein:
Function:
Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MTLNLTKENRIYKKLFTLKPSQRDGLVLNIHHTDRNAQKIRFLSCCFSKNGQTLALADYEGNIFVIDFTSTKFWNIPKFTNTCVMVKFSHFKEGEILVGAHCGAVYVVEAQTGFVCGQLRGHQSPVNCMTFGSNFLCLTGSTSEAILWDLNTNSKLQVLSLQHSCALKYVCFIPVSSYILTCFNDDVIQIWQFGTFEMKTEIPPLVWFNHEVKNITFTQDGKVMVIGCRSPHLALFLLSNFKLFKFITLPEHIQSLKHIDFIPQPNDAGSNKILAILSGRGTVYFYDSHQNVLMSELVANYEISKYDFSASYMACVLSSGDVNIYDVTQYVVVPLKLKAVRAESARKKVKLKRCLEKMGIVKEQIREILEIEKLRMILKECGEFPDSYRTKIWEHLLALPNNRELYNGIINHRMIVSFEDLCRKYPLENKRNLKNLKQLLDNLVTWCPFFLNVDYLPLFVFPFVKVFINKPLTCFEAVCTIILNWCQFWFEYFPLPPINILAMIENVLMVHDPELLDFLTRKKVSSELYAWPILRTAFSEVLTAPSWKIFWDHVLTNEPSFLLCGVVAYNILQRTSILSLKDDKQFRCFYKTHHPIDVKKLLTKSYHILAKTGEAVHPRQYLNMFKKINLGEYPNFCDYPKTMIEMSDKEAEMKREMAGLKTDEVDLFRRRLISLERLQNFEVEEEENKRILEMERAIRNQLLEEQTRVQEYYERVANLREKFHQEDKILASLRHQIAKEQQLKSRRKYLSSIMDDVRFRKGEKGYALTKTEDELLFHYAELLKNKYKIEKLLNTDEVVTSTKLSVDQQQEQLSNEINFVRSSEEPRKHLKMLNLTTGLEAMDALIEKVESELEKQKSGSDSDADRRVVALQAESKELALKIANLIELLANLRSEEVGG
The following text describes a protein:
Function:
Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.
Sequence:
MVKYITPEEIAAHNSEKDLWMVINGKVYDISTFGDEHPGGVEILLDYAGQDGTKAYKDVGHSTAADELLEELYVGDLKPGTELELASLKKDRAVKNSPPPIGLIVAIVLVPMVALFVYKNFISKKTSTSFDEV
The following text describes a protein:
Function:
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; Binds and promotes bundling of vimentin filaments originating from the Golgi.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=More abundantly located around the mother centriole.
Sequence:
MAKLVECVPNFSEGCNKEVIEALGRAISQTPGCTLLDVDAGASTNRTVYTFVGTPEAVVEGALSAARMAWELIDMSRHKGEHPRMGALDVCPFVPVMNISMEECVICAHVFGQRLSEELGVPVYLYGEAARQESRRTLPAIRAGEYEALPKKLEKPEWVPDFGPPAFVPQWGATVTGARTFLIAYNINLLCTKELAHRIALNIREQGRGADQPGSLKKVQGIGWYLEEENIAQVSTNLLDFETTPLHAVYEEVCYNAEALKLPVVGSQLVGLVPKKAMLDAAEFYIKKEKLFILEEEHKIKLVVSRLGLDSLSPFNPRERIIEYLVQAGQEDKGLVTKPLGAFVRAVGGRSAAPGGGSVAATAASLGAALGCMVGLMSYGKRQFEQLDSIMRNVIPPLHQAMDELVAMVDADSRAFSSYMEAMKLPKSTPEERERRVVAMQQGLKTAVEVPCTLAVKVNNLWSSLKMLAHHGNLACKSDLQVGAKMLEAAVFGAYFNVMINLKDITDEKFKTETSQMVTRLLEEAKQGSALVLALLEKREA
The following text describes a protein:
Function:
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Sequence:
MQEERSEKKIGPFKFQSNFEWKEFPQEEFEWFVKEVEKRFGLNLSSYKPQRVKRRTELLLRKYNVGYREYLNMLIKDKKYLDEFMDKMTINVTEFFRNPEKWWELRDEIIPLIAKNSLRMKFWSAGCSSGEEPYSLAILVHELNLSYKTRILATDIDIGVLRRAQEGIYEERAFVSTPKEYLEKYFEKLPDGRYRIKDSVKKIVEFKRHDLLKDPFEKNFDLIVCRNVVIYFEPEAKNELYRKFAESLKPGGFLFVGNTERIFNYKELGFEIYKPFIYRKVK
The following text describes a protein:
Function:
Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation.
Subcellular Localization:
Cytoplasm. Secreted. Cytoplasm, cytoskeleton. Note=Detected both intracellularly and extracellularly. Within cells, localizes mainly to the apical part of the cell.
Sequence:
MDPPARKEKSKVKEPAFRVEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE