lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Low-affinity glucose transporter. Can also transport xylose.
Miscellaneous:
MISCELLANEOUS: Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSEEAAYQEDTAVQNTPADALSPVESDSNSALSTPSNKAERDDMKDFDENHEESNNYVEIPKKPASAYVTVSICCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKVSADDPAVMAEVEVVQATVEAEKLAGNASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDSFETSIVLGIVNFASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWPNGKKNGSSKGAGNCMIVFTCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAIDFYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEVNTLWEEGVLPWKSPSWVPPNKRGTDYNADDLMHDDQPFYKKMFGKK
The following text describes a protein:
Function:
Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including caspofungin or azoles such as fluconazole, itraconazole, posaconazole, voriconazole, and isavuconazole. Does not play a role in the azole resistance in mature biofilms.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNTPDDSSVSSVDSHQPYMGFDDNVEKRIRELARSLTQQSLTSSNRSVNKEAPADGSAPLDRVSTRASSIFSADFKGVNPVFSDEEEDDYDARLDPNSDEFSSKAWVQNMAKITTGDPEFYKPYSIGCCWKDLSASGESADVSYQSTFLNLPVKLLNAVWRKARPARESDTFRILKPMDGLLKPGELLVVLGRPGSGCTTLLKSISSTTHGFQISKDSVISYNGLTPNEIKKHYRGEVVYNAEADIHLPHLTVYQTLVTVARLKTPQNRVKGVTREDFANHVTDVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVWICGSKFQCWDNATRGLDSATALEFVRALKTQAHIAKNVATVAIYQCSQDAYNLFNKVSVLYEGYQIYFGDAQHAKVYFQKMGYFCPKRQTIPDFLTSITSPAERRINKEYLDKGIKVPQTPLDMVEYWHNSEEYKQLREEIDETLAHQSEDDKEEIKEAHIAKQSKRARPSSPYVVSYMMQVKYILIRNFWRIKNSASVTLFQVFGNSAMAFILGSMFYKIQKGSSADTFYFRGAAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPSADAFASVISEIPPKIVTAILFNIIFYFLVNFRRDAGRFFFYFLINVIAVFAMSHLFRCVGSLTKTLQEAMVPASMLLLALSMYTGFAIPRTKMLGWSKWIWYINPLAYLFESLMVNEFHDRRFPCNTYIPRGGAYNDVTGTERVCASVGARPGNDYVLGDDFLKESYDYENKHKWRGFGVGMAYVIFFFFVYLILCEFNEGAKQKGEMLVFPHSVVKRMKKEGKIRDKTKMHTDKNDIENNSESITSNATNEKNMLQDTYDENADSESITSGSRGGSPQVGLSKSEAIFHWQNLCYDVPIKTEVRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERTTMGVITGDVMVNGRPRDTSFSRSIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNEYVEAVIKILEMETYADAVVGVPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWATCQLMKKLANHGQAILCTIHQPSAMLMQEFDRLLFLQKGGQTVYFGDLGKGCKTMIKYFEDHGAHKCPPDANPAEWMLEVVGAAPGSHANQDYHEVWRNSEQFKQVKQELEQMEKELSQKELDNDEDANKEFATSLWYQFQLVCVRLFQQYWRTPDYLWSKYILTIFNQLFIGFTFFKADHTLQGLQNQMLSIFMYTVIFNPLLQQYLPTFVQQRDLYEARERPSRTFSWKAFILAQIVVEVPWNIVAGTLAYCIYYYSVGFYANASQAHQLHERGALFWLFSIAFYVYVGSLGLFVISFNEVAETAAHIGSLMFTMALSFCGVMATPDAMPRFWIFMYRVSPLTYLIDALLSTGVANVDIRCSNTELVTFTPPQGLTCGQYMTPYLNVAGTGYLTDPSATDECHFCQFSYTNDFLATVSSKYYRRWRNYGIFICFIVFDYVAGIFLYWLARVPKTNGKIAKNGKTAKVNFIRRLIPF
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Note=Localizes to the barrier septum and cell tip.
Sequence:
MKMPNTLHSVSISTDFPSPNVESEAADVNEYSSTSKFETLGNQSSTNLGFSNSLQDKWDCWKRDLWSIWWSLSRKATRFYRWLSRSLKWRPVTYETVYPQTYETQMSEPREVTTIVKDLNNGDSFVLNVTEPVDPEFLRANIPPVHRKHLPPRLSLVASPGTIPTRGVVVLEDWINPLLSERCKLLLQSELCNQDSYDCPGYICVYRFEQKNNPSVVLGDSTLIQISRVSDLQRHLREYPKNCAFSRSVLEIFPDPGKTSKPCQVSFKVERLVHKELNEYLSWMQPFTCDSCGSLHENWLQIDSKQWDQIRGVILRWVEYSRVIYA
The following text describes a protein:
Function:
Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDPESEGPAVITVTPLQQMFASCTGAILTSLMVTPFDVVKIRLQAQNNPFPKGKCFLYSNGLMDHLCVCEEEGNKAWYKKPGHFQGTLDAFLKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLTALLRSKLGENESRIPIVAGIVARLGAVTVISPLELIRTKMQSKKFSYEELHRFVSKKVSEDGWISLWRGWAPTILRDVPFSAMYWYNYEVLKKWLCAKSGLYEPTFMINFTSGALSGSFAAVVTLPFDVVKTQKQTQLWIYESQKISMPLQMSTWTIMKNIVAKNGFSGLFTGLIPRLIKIAPACAVMISTYEFGKSFFQKQNAQRQRY
The following text describes a protein:
Function:
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex.
Sequence:
MDGEGFGELLQQAEQLAAETEAVSELPHVERNLQEIQQAGERLRSRTLTRTPHDAADVKASILLGSRGLDIFHISQRLETLSAATTFEPLEPVKDTDIQGFLKNERDNALLSAIEESRRRTFLLAEEYHRESMLVQWEQVKQRVLHTLLGAGEDALDFNQDVEPSFVSEVTIPGRSALDSVEVAYARQIYIFNEKIVNGHIHPNLGDLCASVAESLDDKNVSDMWLMVKQMTDVLLVPAKDTLKSRTSVEMQMAFVRQALNVLENSYKNYTMVTVFGNLHQAQLGGVPGTYQLVRSFLNIKLPGPLPGMQDGEVEGHPVWAVIYYCLRCGDLNAAMQVVNRVQHQLGDFKTWFQEYMNSPDRRLCPTSENKLRLHYRRVLRNSADPYKRAVYCLIGKCDINDNHGEVADKTEDYLWLKLNQVCFDDDGSSSPQDRLTLPQLQKQLLEDYGESHFSASQQPFLYFQVLFLTAQFEAAVAFLFRVERLRCHAVHVALVLYELRLLLKSSGQSAQLLSQEPGDPPMIRHLNFIRLLMLYTRKFESTDPREALQYFYFLRNEKDSQGENMFMRCVSELVIESREFDMLLGRLEKDGSRKPGVIDKFAGDTRAIISKVALEAENKGLFEEAVKLYELAKNPDKVLELMNRLLSPVIAQVSAPQSNKERLKNTAVAIAERYRCQGIAGEKGVDSTFYLLLDLMTFFDEYHAGHVDRAYDIMERLKLLPLSQESVEERVAAFRNFSDEVRHNLSEVLLATMNILFTQYKRLKGAPAGTPGRAQRSLEDRDVQLRSQARALITFAGMIPYNMAGDTNARLVQMELLMN
The following text describes a protein:
Function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRQAVTLPPSWANAQIGPVVTDSREVTPGSLFVALTGERTDGHRFLADVVTRGAAAALVSPEKLTALASNLDTVARPWRLIEPAQAQTLATVPPDACLLIAVDDPLFALQRVAVYHRQMFTPTVIGITGSVGKTSTKEVVAAVCSRRLRTLKSQRSFNSEVTLPATLLGLTADHQVAVLEMGMWAAGEIRFLATLARPQIGIVTNVGPSHLERLGSIEAIANAKAELPESLPADGWCILNADDHRVAAMASRTAARVLTYGYAPNADVRLLDVVSHGLYGIELTVGYEGQSHRLTTPLIGRHHAYTALAAIAAGLVLGLDWDAIAEGLREPGEQLRLRIVPGQHGTTIIDDTYNAAPLSTIAALQVLAETKGRRIAVLGEMLELGAASVEGHQQVGAAAATMADVLVAVGRQAHTMAEAARSAGMPAEQILVCDNNEAAINLLNRYIQPGDHLLIKGSRGVQMETIVAALQATTRNDTGEIA
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Positively modulates defense-related gene expression and disease resistance.
Miscellaneous:
MISCELLANEOUS: Constitutive expression at high level causes severe abnormality in plant growth.
Subcellular Localization:
Nucleus.
Sequence:
MDGSSFLDISLDLNTNPFSAKLPKKEVSVLASTHLKRKWLEQDESASELREELNRVNSENKKLTEMLARVCESYNELHNHLEKLQSRQSPEIEQTDIPIKKRKQDPDEFLGFPIGLSSGKTENSSSNEDHHHHHQQHEQKNQLLSCKRPVTDSFNKAKVSTVYVPTETSDTSLTVKDGFQWRKYGQKVTRDNPSPRAYFRCSFAPSCPVKKKVQRSAEDPSLLVATYEGTHNHLGPNASEGDATSQGGSSTVTLDLVNGCHRLALEKNERDNTMQEVLIQQMASSLTKDSKFTAALAAAISGRLMEQSRT
The following text describes a protein:
Function:
Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity. Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells. By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution; Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein. Synapse, synaptosome. Zymogen granule membrane; Multi-pass membrane protein.
Sequence:
MDTAVGSEKSHLINEKNTKMYTLKLKSPFPGSKEGYPNFPFENGDTATAIELKRPVSVHCHGNRAVCGESHEKQLARKKLYIASLVCLIFMIGEVIGGYLAHSLAIMTDAAHLLTDFGSMMVSLFSLWISSRPPTKIMSFGWHRSEILGAFISVLSIWIVTGVLVYLAVERIVNNNYEIDGHVMLITSGCAVGVNVIMALILHQSSTLHSHSHGSGYHKIDEGGESPISHGHSHSLLGAHGNTSVRAAFIHVIGDLLQSVGVLVAAIIIYFRPEYKIADPICTFLFSVFVLGTTTTILRDVFRILMEGAPKGIEFNSVKDVLLSLKAVKAMHSLHLWALTLGQTLLSVHIAIEENCDPQSVLKEATELLQTKFGFYSTTIQVEHYSEDMAHCIQCQDPVD
The following text describes a protein:
Function:
Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of various genes, including insulin/insulin-like growth factor gene ins-33 and neuropeptide-encoding gene nlp-45. Binds to the consensus sequence 5'-[CT]GGA[AG]-3' in the regulatory elements of target genes. Plays a role in governing the developmental timing of male tail tip morphogenesis. Plays a role in controlling the timing of seam cell development during the larval stages. Plays a role in promoting survival at high temperatures in larvae. Involved in maintenance of the architecture of the ventral nerve cord, perhaps acting via modulating expression of the immunoglobulin domain gene zig-4; [Isoform a]: May specify L2 and later cell fates, creating a temporal switch; [Isoform b]: May be involved in specifying L1 cell fates.
Subcellular Localization:
Nucleus. Note=May associate with mitotic chromosomes.
Domain:
Despite no sequence similarity in conventional searches, based on an AlphaFold predicted structure, the sequence-specific DNA-binding region exhibits structural homology to known BEN domains, for example in human BEND3 and fruit-fly protein insensitive insv.
Sequence:
MGKGQPKEPKIEQSVVDLCKRTVAMNLLQCYPTTTVDEMNCEEWGNGTESTQSVAACQGCIELRKEVTDLRQAVNLILPMLPLYPTIGNGFNATGLAAQPTLQHVIQQSLLRKRPVAQTPTVPQPECPGQIRPVLSSPAAALQNVIMLNPWIMGSSLKPASPTLPNGQIPTTIGETSLQGTDDQTVKWIGPSSVDSNGQKTDSSAASAGDNQNIDVIGDGSESPTSSNHSAQEIALMTSQQTFLNALKDSSFLFTNPVPTVETAPPLRVAPPINGTTNGTAKAGGPERKPRKPVNDDIVKIVRNQDLSEENISMFEIPVPKAIASDPTFRPVSEQQIIQQIIQGKKYEEMEVGECMIQLCKKLAEKRVFGPRLMSQTTVAGLNHSNYANLPIKGICYIQHVCRKVLYDKFENEEDFWDKFREAMRKLAARCRRVRHAKKTKHNREEAQAEMLSKRYGEDMPFNLNGAGLIRPKVETVSPEANILNSDQIKSQLESLFAHIPKTESETPLIEIIQQNISLFTHLIRTKVESQSPPLQGPQ
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
Subcellular Localization:
Cytoplasm.
Domain:
Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs; The N-terminal zinc finger binds to poly(A) RNA; The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.
Sequence:
MYPYSQSQQPPYHHPHKQQSQPPPHFNHTHHPPSLPHPSQQQHNQPYAQQTTSSTHLHSRPAMQQHHHSQHQIQSSAFNGALPPRPTRSSAIPIVAPASTPAPPAAPSKSAISYGAATAVGTPPQSETPKSPIASNANASARKPCRNVAIYGNCKYQNDGCPFDHASASTSSSAVQQLKSPASQNASALSAASPANSPNKTRGALNPPSSPLKGSLSARNVAAAVFVPKVNGSSSPSLSVASPAPASRSTLDAVTSELSDLRVDSSTTNQVSPSAYTHNGPSTPNMYTSSYDVDPLSSSFDPTHPSSTAAHDQQIATATPSAHASRPYNPYEHMNEFGDPSPGQGPPGIGLSAGIDYYSAAANGAAKIRQPLHYHLYAPPLPHVSNLHPHHLTANAFFLHPNQREELQRKQEAMLASVPPPELGGPNLPEELHVYHSLVPLEHPGPGAPSTMGMPPGLIDPRMGNPGSNGATGASGDHSKVFGYRSHSYKATCTLDGKRYVLRRLESFRLQHEAAIALVERWRRIRHPSIVSVREAFTTRAFGDQSIVFVYDYHPLATTLYAEHMTIKAAQPDRRTGRLQPVSMQVPERTLWSYLCQLTSALRSIHSSNLAARCIEASKVLRTGKNRVRINCCSVFDVIAYNPDETGSDALKAQQQEDMVNLGALIVSIGLNSISATNDIASSLATFAGRYSAELKNVVAWLVAQTPAPYESVGGDDVVEVARNVTELIKVLGSHCADEMDSALNYTDLMENSLMKELENGRLVRLLCKFGFINERPEFDHDPRWAETGDRYVIKLFRDHVFHSVDEAGRPVVDLSHILTNLNKLDAGTDEKIMLTSRDEQSCLVVSYREIKNCIESAFQDLSRTR
The following text describes a protein:
Function:
Dehydrogenates steroids by introducing a double bond in steroid ring A.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MAEQEYDLIVVGSGAGACWAPIRAQEQGLKTLVVEKTELFGGTSALSGGGIWIPLNYDQKTAGIKDDLETAFGYMKRCVRGMATDDRVLAYVETASKMAEYLRQIGIPYRAMAKYADYYPHIEGSRPGGRTMDPVDFNAARLRVTALETMRPGPPGNQLFGRMSISAFEAHSMLSRELKSRFTILGIMLKYFLDYPWRNKTRRDRRMTGGQALVAGLLTAANKARVEMWCNSPLKELVQDASGRVTGVIVERNGQRQQINARRGVLLGAGGFERNQEMRDQYLNKPTRLVDGNPCGRQYGDAHRAGQAWAHTGADGLVLGRAHHGCSQGAGLSRHFRGTLAAGVHGGQRQGAALPQRVRPVSGIPAAMLAENAKGNGGVPAWIVFDASFRAQNPMGPLMPGSAVPDSKVRKSWLNNVYWKGRRWKIWRADRRGRAGLQVSARRMTEYARAGKDLDFDRGGNVFDRYYGDPRLKNPNLGPIEKGPFYAMRLWPGEIGTKGGLLTDREGRVLDTQGRIIEGLYCVGNNSASVMAPAYAGAGSTLGPAMTFAFRAVADMVGKPLPLENPHLLGKTV
The following text describes a protein:
Function:
Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. Probably undergoes several conformational states in order to translocate the substrate across the membrane; keeps the substrate accessible to only 1 side of the membrane at a time by opening and closing 3 membrane-internal gates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGGEKAGKRGMGFWTCSALVIGNMVGSGVFLLPSSLAAFGGLSLFGWLVSSTGAVLLALTFARLARVNPGAGGPYAYTRDGFGSFAGYLCAWTYWKAAWIGNAAIAVTLVGYLRVFIPALADPLLMVSVAIAAIWLCTLINLRGIGTFSVVQNLLTILKLLPLLLVGILGWFHFNPEHLAIPARSELPNMGYAQAIATTAALTLWSFIGLESATVPADDVEDPRRTIPRATLFGTLAAAALYILSITAVQGLMPPEVLARSTSPFADAARILMGDWGYYLVAAGAVIACLGALNGWVLLQGQIPVAPARDGLFPESLGQLNKNGAPAHGLLASGLLVTALVMVDGHGDLVDVFNVIILLGTMTGVVPYAFCTAALLQLLAVRPDEFSPRSRRQLLVIGSLGFAYSLWALYGTGQQAIFWGFLVLMAGIPMYTWRQWRNQVNGVPTLKAND
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MAEANKDQVSQPNNNAMQNNNADSVDPELNLGLSLGEIYTENPNENALARSSTMAGFLKPKTTPEEEMVAAPLPSVQLPRSSSVPEWTGQRMIRHKDILALRRMERKKRLAEKLRKEELAASLREKTSPPAAQASQPPEANATGPLSTVFKFELKAEGYITVSAASNGAGCFETFPSGSDIKPVVTSSKVATLEHVNPAHNAMENPSKAARFSNAVVPKEELTSKMPSVRTFGADGRKTEGVLYKYRQGQVGILCACHGSFLSPAEFVKHAGGNEVANPLRHIIICSTPCYD
The following text describes a protein:
Function:
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
Subcellular Localization:
Periplasm.
Sequence:
MKILILFFICLNALFALDSNALKAEIKEVYLKEYKDLKLEIETINLEIPERFSNASILSYELNASNKLKKDGVVFLRLENDPNLRLPVRYSVIGSMQAFKSVSAIKKDENITANNTQKERILFGALSNPLLEGAIDKVSAKNFIPPNTLLSTDKTQALIIVRKNDIITGVYEEGQISIEISLKALENGALNQIIQAKNLESNKILKAKVLSSSKAQIL
The following text describes a protein:
Function:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium.
Subcellular Localization:
Membrane; Single-pass membrane protein. Secreted.
Sequence:
MCMFSESALSPVFQIVLYGFVGCHVFPDSDLDQGMAFELDNNFVPSCKIGSGISAALKKGPHSNFTRCGSASLYQHSRLGSSRTWISLVSLIMAFRFGITFFFFSVWIINLTIQGTFLSKDIYTSKCRIAGITLVSYKNQANFNFTEAQQVCRQLDLMLAHNSEVEKAWKHGFETCSFGWVAERYAVISRIIPNEKCGQNKTGVAIWRLPVNRKARAYCYNSSDTWVNSCIPEATTLALPDVSTEMNSTSTFLPQDTSAIVQTSEPPQTKGLQKLYRVKCVTEIITPKPTTEEEIVLSPDKRTAFKNDGVQFGGVPIALLVLALIFFVASVVLAVCYIKK
The following text describes a protein:
Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm, P-body.
Sequence:
MTDQVRSDVQEKLVQSGEYEKLSQHIQARLRNSGWYDKVSALAQEEASKQDKVELSSLLEKVQPQACDLVDDDIKVETLKMIASFLEGALK
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MDDDALNMRNWGYYEPSFKGHLGLQLMSSMAERDTKSFIPMRDPNLMVTPNAAFHPRDCIVSEAPIPMNYVRDSWISQREKFFNMLPGISPNYGILPETSAAHSLPILQPSPNSSTRDERVVGRVEESPATKESVELKKRQSESAPKTPKTKKPRKPKDNTNSSVQRVKPAKKSMDIKINGYDMDISGIPIPVCSCTGTPQQCYRWGCGGWQSACCTTNVSMYPLPMSTKRRGARIAGRKMSQGAFKKVLEKLAAENYNFNNPIDLRTHWARHGTNKFVTIR
The following text describes a protein:
Function:
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MFTSSSEDFQPLSFPRLVMITEYLLLFRVYGLESLRDLFPNLAVIRGTSLFFNYALVIFEMPHLRDIGLFSLTNILNGSVRIERNQELCHISTIDWSLLQPLHSLEHNIILHNKPVEECADVCPGMLGVEKPCVQTQKGLTGQMEYRCWTSHNCQKVCPCKVGGRGGGAVEATDTAAAACTGNGECCNPECLGGCSRARDHRACVACRHFELNGRCLRSCPELTYQYEGWRCVTAEHCASLHKVSENPRDSSRFVIHQGQCLSECPSGYKRNDSSIFCHKCEGLCPKECKVGTKTIDSTRAARDLTGCTLVEGNLIINIRRADNLISDLQGSLGLIETITGFLKIKHSFALISLSFFKNLRLIRGDSMVDGNYTLYVLDNQNLQQLWDWSRHTLFIPAGKMYFAFNPRLCLSEIYRMEEITGTKGRQNKAEINPRTNGDRASCKTQTLRFVSNATESDRIVLKWERYQPPEYRDLLSFIVYYKESPFQNVTEYIGQDACGANSWNVVDVDLPLNNDQEPGVILQNLKPWTQYAIFVRAITLTTAEEGRDYGAQSKVVYIRTMPAVPTVPRDVISMSNSSSHLIVRWKPPTQPNGNLTYYLVLWQQLAEDSELFVNDYCHKGLRLPTSSADTRFDMDNEGREDAEDEQCCPCQSPVGQAQLGGETVSFQKKFENFLHNSIIIPRPPWKVTSINKVSHRIPKRRRDAASAPAAGHLFADPSPPEVSRKTAAPNGTETDPMAQKDFRISEDKVVRERTAIASLRHFTEYRIDIHACNHAAQTVGCSAATFVFARTMPEPQADNIPGNMTWEPAGKNTVLLRWKEPQNPNGLVLKYEIKYSRESEKVVSVVCVSRHRYAQYGGYHLALLQPGNYSAKVRATSLSGNGSWTGLIKFYILGPEEEEAGNVYVLLILMPVVLMVGIACLAIFVFLYNKKRSTEGYPSGTLYASVNPEYFSTSNSEYSNPFQIHSCGGEGRGLNEGKSLAKTTWGQVLLFLLLWQLCLCWWNWHQKASAALSLMVFLLLNLSFSYSLWPVYIPDEWEVPREKITVLRELGQGSFGMVYEGIARDIEGEGQETRVALKTVNELATMRERIEFLKEASVMKAFRCHHVVRLLGVVSQGQPALVIMELMMRGDLKSFLRSLRPEAENNPGLPPPSLKEMIQMAGEIADGMAYLNAKKFVHRDLAARNCMVSEDFTVKIGDFGMTRDIYETDYYRKSGKGLLPVRWMSPEALKDGLFNTHSDIWSFGVVLWEIATLAEQPYQGMSNEQVLHFVMDNGILEKPENCPEKLHELMTWCWQQNPRLRPSFIQILESIKEDMSSSFRTHSFFYSLENKHCSSWEVLDAETDQLLVSDASVLDVPNGRPLLSLGPYMEQGPPTECKPQPNGKPSL
The following text describes a protein:
Function:
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
Sequence:
MLRTVAGFGRPNNHREVNQRMAKTDARSPRTERGTIALQDASQDIWDKKYRLKSKDGTPVDASVDGTWQRVARALADVEDKASREHWYGRFLWALRNGAIPAGRIISNAGALGHKPATSTINCTVSGTIQDSMDNILEKVHEAGLTLKAGCGIGYEFSTLRPRGAYVSGAGAYTSGPLSFMDIYDKMCFTVSSAGGRRGAQMGTFDVSHPDVREFIRAKREDGRLRQFNLSLLITDQFMQAVEQDADWPLVFPVHVKERDEIDLDDPNAVVWREWPIQDDYVQRADGLVACKVYGQVRARHLWDMIMVSTYDYAEPGFILIDRVNELNNNWWCEAIRATNPCGEQPLPPYGSCLLGSVNLTCFVEQPFGDEARFDWDRFREVVRVFTRMLDNVVEINGLPLEQQRQEILGKRRHGMGFLGLGSTLTLLKLRYGSPEACVFTEEVAREMALVGWEVALELAREKGPAPILAQDYEVTAEMLRKRPEMAADGYKAGDRIRGSVLHAKYSRYMQRVAEHAPELIEALAETGARFTHHSSIAPTGTISLSLANNASNGIEPSFAHHYSRNLIREGRKTKEKVEVYSYELLAYRTLVNAQALPDSDDPARRLPDYFITADSVTPAQHMDIQAAAQKWVDSSISKTANVPTDYPFEDFKDIYRYAWHQGLKGCTTFRFNPEAFQGVLVKESDLEKTRYRFELEDGSVVEFKGNEQVEYDGEIHTAANLFDALKEGYYGKY
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MAHNWGYKSTNGPHTWAEHYAEAAGERQSPIDIQTSDVTLDPKLSSRQLTWNWPKHTVDVTNTGYCWKAHVHGEESSLEGGPLKDKYQLEQYHCHWGVNDNVGSEHLVDGKAYAAEIHFVHWNTKYGSFSEALKHGDGLAVLGVFVEVGKEHGEANNLIKALNNIRFKDETVKFNDHLELDPSKLMPANEPRSYWTYLGSLTTPPCSECVIWIVYKEPIQMSHEQLEAFRAMYCGDKEQCCAANEMAECILTNYRPCLPKGERCVRASYT
The following text describes a protein:
Function:
G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGAVRIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCQKRLKEVLQRPADIMESDKGWASASTSGKPKKEKASGKLYPESEEDKEVPTGSRHRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPTAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLGLPLSPRLLPAAAATTTATTNGHPPIPGHTKPGAPTLPATPPATAAPKDDGFLNGSCSGLDEEASAPERPPALLQEEWETVM
The following text describes a protein:
Function:
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MQRVAQTAIEAGKAYARLAGGDAAAGGDGAIGLLRRALLYLPAHDHRKVVKASTLDVDLICLDCEDAVAEARKPDARQAIPDILSSTNFGRSEVAVRINPVDTPHAWHDLEAVLGASTRPHTIVVPKVDTPEQMEWLYDAVQTLSPDSNTKPLHLITQVESAVGLHFLHDICQVGKDRGSAEDRRIIHDGLILGGDDFAASIRARRTPSNRELLLARQQTIVAAARFGLTAIDIVNIHYKQGLDLLEQEASEGAEMGFDGKQVIHPVQVPIVQAAYHPTPQQIDYARRLVDAFNAHSDAGTGAFEFEGTMVDMPTVRQHQQVLWMDNHLQAAAAQK