lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MSLLHEKQVRVLKLFERLSVAASGEKIPADQIDARLSTVGELPNSAFFSCFLPAHLEEAKRLIEIFYSAKDFDDFVLLAEQARTFVNSTLFAFAAEVAILHRADSRGIIVPPIQEIFADRFVPADTLIRAFSVATTKPAGDESDVIIDVQETGNILDPEYKLAYYREDIGVNAHHWHWHVVYPSVYDSKFFGKKKDRTGELFYYMHQQMCARYDCERLSNGLTRMVPFHNFEEPLEGYAAHLTHIASGRHYAPRPDGLAMTDLRLVDVQDMQRWTERILEAIHLGKVIDSEGNDIILDEETGADILGSLIESNLESKNRQFYGNLHNWGHVMMAYIHDPDGRFRETPGVMTDTATSLRDPIFYRFHRFIDNVFQEYKKTLPVYSRDNLTFPDIEITESKVNAKITNVIHTFIREDELELTHCMNFGSPGSVKARYHHLDHESFSYIFNANNNGSEEKKGTVRIFLAPKYDELGNVIPLDEQRRLYIEMDKFDTDLRPGKNIIVRSSTDSTVTISSTYTFKELLHGEDLEEDRSEFCSCGWPQHLLVPKGSNKGMVFDLFVMITDAEKDKVPTSGKKLCNDALSYCGVMDEKYPDKRAMGYPFDRTITAQSHEEFITPNMKISNITVRFQD
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MGDSANTASVRFPLSADAAAEALAVAGQQRGAAHLLSNEDDVDEDDVYEESEERYNSDDDAHGGERSLPAKTAEAAASVFMKGTPRSFGPVAGAGGDLGSGAEAKGAGGSAAASLNAQRSALIAANLSRQLFKAKMPDIAASTKYQDELEEEDLDQLSAVDRDFVMNTKDLFDDVDAELLGEDFVPHEHVVGIIASEATGGEASPDEIDDNLVDYKDLEAEINADLADYIDAHHQEFNNAICDFSEMVLAVSGSDDTLAEFKKELADAIVSLESHAGELKVLRLRAAKSLFMADALEHIQEVVLAEAEVKGLLQNRHYLAAVQTLQAQARLLAGDELKGVRAVQSLRDTHNATISTLHHLIIDDLLACVFRHERLVEADAQLLQEMLDSSERDTKDTHAAAPSVQHTIYKYWKMAGVGAPGSGHPDDDEDDAGEVDRDDGLVAATHNGTTAGSTKTAGVGGLARKDRTLSAIIETLTDDPRDDQVLGNYLKFVPLCVKSLMLLGKIDHCHETFFSRATRSMERFIAHFLCLYDAWRRRTRSGASLSNDEVEAAIRGTHVRALDLACDLISFDEAVATIQARDLRAMLGALFTELEKILRNAAYLQKVVLVAHFPFVSPYVVQPDPFVPEATSRQWNVMNAPLRNEMWLHDTLTTALDHAQNSMRNAPAQSDKSSSSRSLPAAGGDSNVGDVIAKFLELFNTDAVLASLKAETEEKDVAAAAAAAATTTPVNLKTSGGVALNTDAAANDVSLFLAFDRRKPCLTLQNILDRVNSACAQTRAIFPAAEAVLRKLQLAVSAELRDAVRVKLVAEVQTLLQEWDLQALWSQLNYHIECVFHVICDAKESQDETDDAVTLLPFLRQKNLISRVQRTATIMLDADKQGDDTTTLDRLLSTYASGGLLRMVEETGTVSFSLVGAVKKAQADMRKAREGQASQFDVMQCDKAKLIAFTDSGLGGGGVGGAGAPLVLLHASMLRRWFVFTAMNALTCYECAARFYSRSCDRVPEFRLLSEEECVVGFFKRFLRATYIPTLHAFHSQQLQLLLMSIGDSGGTSAAGATPSASPLPEDAGSTTSRGGKAPTAMKALSGAWPTVVVDEVQHPILACVQYVGQVLAKVSDVRRILPESLTEEVEQNTSEALIIELVVFLKRQVQWLGRGTLAHRLLDKPFEDAFSGMPNRRWAALADEENILDAHRYIDQDLYRYYQLNSDERTSGHEYNRSTVSVLEAMRVLETSSAASPGDGGGAGAAEAELDQHIGRMEPRDICVRDDSTLVAFALLCTSAEWLCDVLLRYLWPRRRRARNYTDCCVPGYCFAHEMRVSDAASFVLVDGDYTMQRKIRLSGHLVRLCSLAQVALFHLSVEARFLAFLFLPQLRDVSYDVVAVSSAADMFVQAYARRVHNFYAILRQHLHAKKIKYTCLTAGKPASELILMELAHLRDKAISQAGLMRLRTDLLVMQTTLQLVLPADSDVREAVSRFFLRPVLFLRHIFNKDVVNEIVSSLDYLNFSTKEVEVLIRLVFRQVSGSNDDTLAVQQIRFFYQKLKTIRNLRCAGNRTGGGSSVVSEPSLLPDGRGSSADAIGGGGLPSFVPLSTNAAAVAAAALDDGDDYHSGAFSYDDGGSDASDLQPPPLPLSSATRGCQSAAGGLAASPSMSAPPESVPAPTSASAAAAPVSARLTTSSEEDEEDDEGEEDEETPEASTTLRPDRQPQQRPIPRGADRTRSSISAVAPAGAEATALGSRPTRRVDPTSLPDTPCLPSSKSATAAKPALARPVVPPLAMAPFRGAPSKAPAPAAKAGAVKVEASSEEDEDDEEYEYEEETSEYEEEEEEEEEVEEEEEEEEEVEAAPVQASTDKRPPHPRPHPAGSPTNGTAAAIRRPSASSAFAPK
The following text describes a protein:
Function:
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
Sequence:
MALRFSVLRLASYLGRKKDLYQILEVESSATHDEIKRAFVRLTARLHPDTRGVDKESERLQWSNRSLTEQFMEVKEAYDILRKPEKRKEYDEERRLAQGLDGHLVEATSARFEKNTVINLQRDRNEMYTGPGKKRDDSASGHFRNPEEEYEKERQKNRSLYLIGALFLSIVLTNIGYVHYLRSSDNRKVL
The following text describes a protein:
Function:
Probable RNA helicase required for axial polarization of the oocyte during early and mid oogenesis. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Required both for the translational control of oskar (osk) mRNA and cytoskeletal polarization in the oocyte. Required for somatic primary piRNA biogenesis. Involved in repression of long interspersed nuclear elements (LINEs) including HeT-A, I-element and TART LINEs.
Subcellular Localization:
Cytoplasm. Note=Component of Yb bodies, an electron dense structure containing Yb protein found in somatic cells of ovary and testis.
Sequence:
MFTYVSKFFTNPDRNREDILESLDRENSFLDQKLMEEKMDQQLKANPNEINGVLSNKIAELTHGLSEMDVSKESSCTARKGVITSLDGDRGVIDKDVLFETKVAEDIILDLHVGCVVEYLTFTTGEAMRVVKVKSILEHSWEDTSQKEIEKAVDNLKNEKPTFFNTETRSVLGLISQRLASSIDVETEYGQLTVELDNIEMNFIPTNGDRVRLECNIQLDDGFVDKQGEILEVTKLFPTRIQEGEKCIVERVYVHMVVLGPETYILKTDLPTGTDLHLGDIVLADLIECQYSKFTRRAIKITPLEKNFGATKLTQQSSMGSSGSGKAVTVTGVNRFITAELWQKESVSLKLTNNLNRTLRLESITVCNDSESQLSVVSPLESKEISSGSEITVTFEIHTQFLGEAIEKYVLNFDLLKVRRVFTVIVCKTKEEVAEAEKRMIAAEALMAPGRNSQERSRFYANQVWCNKVDVIPGQQIVTKRRFVALRLGCFEVPKELRQICLTSERRQEMIKAIEQHYSFLTEPLSIKTYMHRFRLLLHLEEIECFVNFRNYDRDRAHFLRDGEFLTLQIENLAERRPSLVIGDTLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSSFQEKYNGEDYRLEFYFSRYSFRKQHHAISKIVGVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLEWYNQSLNSIQKRAVFNILRGEAENIPYVLFGPPGSGKTMTLIETLLQLVRNLPGARILVGTPSNSSADLVTKRLIDSKALLQGDFIRLVSYNQVEKDLIPPEIMSYCATSDVGAVGSCEDKMMVTESGLKLRCQAKFIGTHRITISTCTTLGNFLQLGFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKRSQVVLSGDPRQLQSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRCVFESEKDIPQAHGTFFYGIIGENRQNNDSPSWFNPQEVREVFLMTIALYRANVTADQIGIITPYQKQVKMLRSMFIGTDVVMPKIGSVEEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECWRQLILFCVKNNAYFGCDLPQMVINQKDEVPVCLETFVPSLNTTDDLN
The following text describes a protein:
Function:
May function as somatic storage protein during early seedling development.
Sequence:
MAFPRSSSISFFTFLLFSVLINTAISSRVSSFIKLPTSVDESVSSSLESYCASWRLAVETDNAGKWKVVPSQCVSSLETYYDKGQFDKDYSVVAGYAYAYAKTITLKGDGKDAWVFDIDETLLSNLEYYKAHGYGSEPYNSLAFNEWVLQGTAPGFAASLKLFNRLKKLGFALILLTGRDEVQRSVTEQNLLDAGYSGWEYLLLRGHQDQGKAAAQYKSEQRSRMVKEGYRLHGNTGDQWSDLQGFSVADRSFKVPNPMYYIA
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MAFLYENEGTTRTLLHQVLEMHPLSSPISTNNRSRSCTESLFASSDTTLRKRKKTAPVQPKDTGGTDQHFVEHYDLLEKGTPRILLKKILQTASEDSVLVPVLMNSQEPVPVELQEESKWNSLELQLPEPEPSASLAPELLIHSRRKRCLRVSEFEQEVDQGLAVSSDLTGEKRASANKSSMSRSFNLTLATVIPPESVERPGLARRPQIRKKVDMEAFEHGLKDIPLTLLSDRCSNHSTTPVDGARSFQSSPYSLRFRKSLTKDQQPRATTYQANQRKKGPRRAIKSWPKSPLQNQPPSANSMSIRRQARPWTGRPSQNSYLSAYSVLATSNISREAVAKSDVVYQGEEEEERLMVDQAEESEEDTETPQRAVVSELSMKTPEFLQAKRHRSFSQPASLAPPNIVLLPSKLTQAKCAPKRCATGPRQPRDPDKASLDHYCKVFSYYAKMPVEKSASKTLVKCLDQYFRTLCDDLETFAHHAGRKTVLLDDLELLMRRQGLVTDEVSLYVLVERHLPLEYRRLLIPCAASGNSVFPAGAHKAKERDRKEKQRYWSWLPRSEQAPFPPMWIWMEKISQKRTL
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATAPAPADAKAEAAKMDLLEDDDEFEEFEIDQEWDDKEEGNEAVQQWEDDWDDDDVNDDFSLQLRKELEGASAQKS
The following text describes a protein:
Function:
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
Sequence:
MSTDQRDRLLEGVGWKARGDRIPEFPNPRPFFPRLKHSIKLIPLFVRVALHTFVEWWNGREAFIDIFNVFRHFTYTGVPLGGIGSGSIGTDFRGGFNRFSIIPGIKEQTETQKCNQFIASVHSKKTFELIYQSILSCAEFPATVLPKWDSTIPAEDVRYRGLFPRAWQEFRLGTSGITVVVEHLSPVIPEDYSDSSLPLANFDFHVFNDSPEEVEVSITMSFRNGTGNKKWNDESLCQSHKVQKDTMVVRTLSHTVKGMPVTYAIGTEEKNGAKVTTCLFDPNGTGGRLWSDLEAYGHLSSYDHLPPKPKELGIAVCSSFFVPPDGSHTTQFSLAWYMPQVHFGTAERFYNRRYCRFFNGPDADEVGASICRHGLQNIETWQEAIRKWQDPIINDEKLPEWYRSAIFNELYYIVDGSTVWFEYDPEWRTDEILISEETEKQFKQYGRFGYMESWEYFMINTYDVHFYSSWAILKNWPQIEMSMQMDFADQVDRVDYGTATSLADGDTMTIKSYDRIPHDMGHPSNPHLPSIQEHHRLSVADPWIHTNAYILHDTGHWKDLNLKFVISCYRDWKMIAEGEEDSQEILEFFLGKCTKIVDGALENWDKDKDGMIENDGFADQTYDVWKMTGTSAYCGSLWIAALTSYIQMLKRAGIPTKDYEEKLLMAYEAYTTKLWNGKFFKFDELPDNSKIVMADQLCGFWALTAMDEPIQVSEGKIQSALETIFKYNVEMYDGGKCGAVNGFLASERVDGSSIQSEEVWAGITYSLSAMMIEKAPIYLQGMDEMAFKTSEGLFHSIWNRFPLQYQTPEAITADGMYRALGYMRPLSIWAIQHALDKKKNRK
The following text describes a protein:
Function:
Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and pigmentation.
Subcellular Localization:
Secreted.
Sequence:
MWRLLLALLLVSSVCCESELFRDDLRTPETMAYINGLMQRRHQMQQEAQQHIQAIPPAVPLQSPGLVNGLGNQNDPALNRISGTSVKPSNLPAAYSNGYVDLATSDRIANSVLNFANILGQHLANGKTQIYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPDTSRLHEQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILANALYFKAFWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYIIQPFKSSVRELMALQKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASSVTYLKKSGPDVLFRGDTPFMVLVRHDPTKLVLFYGLINEPPAAA
The following text describes a protein:
Function:
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid (By similarity). Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 (By similarity). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSPCGRARRHTSRGAMAVLAWKFPRTRLPVGASALCVVVLCWLYVFPVYRLPDEKEIVQGVLQQGTAWRRNRTAAGIFRKQMEDCCDPAHLFAMTKMNAPMGKSLWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEADFVMRCNLPPLSSEYTKDVGSKSHLVTANPSIIRQRFQNLLWSRKTFVDHMKVYNHSYIYMPAFSMKTGTEPSLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQLDPCEDNSLQPTS
The following text describes a protein:
Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MQCSWKAVILLALVSIAIQYTAIRTFTAKPFHICPVPNPLNCGLGQDVESFDRMCDEYPYFNYNSSRKTHILILATTRSGSSFVGQLFNQHSDVFYLFEPLYHVQTTLIPHLSPSRYAVERRVMLGASRDLLRSLYNCDLYFLESYIKPQPANHTTDKLFRRGASKALCSMPVCDAFSPNDGNIEEGDCVRKCASLNLTLATESCRERRHVAIKTVRIPEVNDLKALIEDPRLNLKVIQLVRDPRGILSSRIETFRDTYRLWRIWRATGRKPYNLDLTQLTTVCDDFLNSVSTGLSRPPWLRGRYMLVRYEDLARNPLQKTKEVYEFLGLSLEKGVVDWIHNNTRGNNDVSAKHKYGTLRDSAANAESWRLKLSHDIVDYTQTVCQHILDELGYKAVNSPEELKNMSISLIEDKTFIPFL
The following text describes a protein:
Function:
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells (By similarity). Probably plays a role in the proliferation of vascular endothelial cells during blood vessel development. Establishes anterior identity at two levels; acts early to enhance canonical wnt-signaling by repressing expression of tle4, and acts later to inhibit nodal-signaling by directly targeting nodal/nr1 and nodal2/nr2. May play a role in liver development. Induces heart development.
Subcellular Localization:
Nucleus.
Sequence:
MQYQHPSSSALGLSVPLFAPTPLQHPTPFYIDDILGRNSASNGTPALPTPTLPSPNSSFTSLVATYRTPIYEPTPIHPAFTHPGAALAASYGASTYASPLYPFSRPVSDYTHALIRHDSLGKPLLWSPFIQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQGNKKDETESLENICEESQERCLSAEQKSRESSLDDPTSSPTSQGNLDSEVSDDSDQEVDIEGDKGYYNCAH
The following text describes a protein:
Function:
Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.
Subcellular Localization:
Nucleus speckle. Nucleus, nucleoplasm.
Sequence:
MFAMYNSYNEAEKTVFVGNLDSSVREEILFELFLQAGPLTKVTIAKDKDGRQRSYGFVCYKHREAVPYAIALLNGICLYGRPIKLQYRLGSSHNAEAHAVFPVLENGPGKPSQESYRTVCCQKASVFPSSAVSTCLSQENLCWQNPMFCSPIQPYSMDAQIAQQQSYLPDAFSQQSRMTSLSWFVQSCPASSSFVQWTHAQQDQQDQLSEFLSYSWVREGQVVDTWDTDQKERRTKKTQDGKQEFRKHKSKHKI
The following text describes a protein:
Function:
Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading.
Subcellular Localization:
Secreted.
Sequence:
GTVFFDQDSPDSPVKVTGEVTGLQKHGFHIHEFGDNTNMSADGSSYLQVSGSKLTQEGQASMEVKGNAGARVAXGVVGIAK
The following text describes a protein:
Function:
Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
Subcellular Localization:
Mitochondrion.
Sequence:
MREIVTLQFGERSNYLGTHFWNTQESYFTYPPEAESPVNHDILFRPGIAPDGSDTFTPRALIYDLKGAFGSMRKINALYEPEDDRSILDQPGVWPSKPIVQRTQPIPPSTYQEHLDNGLDPPALNISSVRYWSDYSRVFYHPKSIAQLSEFDVNDTLMPFEKWEVGKGLFEKLEREVDLVDRDLRPFVEECDGIQGLQIFTGVDDAWGGWASGWIERLRDEYGKMSIWTWGLGDQGANAAVGRERRLQQMVNASQSLQTLGEQSSVYIPISNSPTKTPSYLSLDATSLWHVGALQAIGLESMTISSRLRTSVGGRGNLQDLEDTINSTGKRRIGKFEMSIADPEVLSENYSKEMAQAEKTGSMTSRRTSEDDEELSSFDIDVFTRDYRAVSRSGKKEHVFGRAEVSRGDWNLTDDNEARDPHNRFNQGPTLQRYTAPILFPLLDSYPTSIFDVGSGLGTKLAVHAGLTTSTAVAGQIRAVEQIVKRLVGIEEREALCNGLQVLAEEYDEGWDSGTDSDDDG
The following text describes a protein:
Function:
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.
Subcellular Localization:
Endoplasmic reticulum membrane. Membrane.
Sequence:
MVNEPLDSQSTTTVTAQPIISIGKPSDDHDTQTSALSDTATIVALILRLIFGHTPWLVYRFLSYTVTATITLDLWSVLGLLSLISLVVYLLIRYRLLNTYTHLKTPAPIAPRAPFDLQPDATLDDDTDLNKGYPDEFMNAFLSSIKVFGYLDKPVFHELARHLQTRKLKTGEILFDEDSEDRDFYVVVDGCVQIYLKGNSNALARHSLGSNNFEDRSDSDDPEDEFSGHHLLNEVKAGETVSSLFTILSLFTEDFELSTLMQPHSAATNLNESHGTSFSSKHSGFPQAQSPAFSTQLDSDESAWLRFNHLQQDSSIDSTPTPETAHPDAKPPHGLDGSEDHKHFTHPTSGNHIPKRKHRSVHPGIITRASSPTTLAVIPAQAFRKLTEKFPNAAAHIVQVILTRFQRVTFLTLYRYLGLSKELLKIERQVNQFSGYGLPTDLFPPEILHDLRLRTIRKRRGINNTFVTNEVDSSNGNEVDRRMSEMPGSRGTYNVNDDTASLTISMGLTHSQQRNHRRAHRNVVEINEYNNTADSSENDTAGPAKPPRKPNAKSSYRPTRLNDEADGPIKEAVFKCIAQLIGMRPYSGPPGHSNLAPMTDRLYYSRSRTSWKPTSSTVFSIGSARASHPKTPDETTSPSNSTGNFSIDSSDQVEIDIMYFEHGQTLVKEGERGAGLYFVLDGVLEASMSTSNSQLFPIRTGDASQNSNPSSRGKSRRNLFLIHPGGLAGYLAALTGQTSFVTIKAKTDAHVGFMSKQVLDKYVERFPDILLCLAKRLVNQLSPLVLHIDVALEWGQVNAGQVLCRQGEPSTSIYIVLTGRLRAIVERSRNGIESLDILGEYGQLESVGEMEVLMDAPRTATIHAIRDTEVAIMPKTLFNALAIGHPEITISIARIIAARSTQSFLGKMGPGQQPSFNMRGSPDSGNNNVNLKTVAILPVTSIVPVFEFADHIRDALQLIGASVAFLNTASVMRELGKHAFTRLGRLKLMSWLSEQEESHRLVLYVADGGVSSPWTQRCVRQADCILLVGLGDEDPGIGEFERLLIGMKTTARKELVLLHNQRACIPGSTAQWLKNRVWVHAHHHVQMNLNTPKLLNKTTQKQLTLINLKSHFQRVYTSMYPMNSTGKKSSAPNIYSGVRSDFARLARRLLSKSIGLVLGGGGARGFAHIGVIRAFEEAGIPVDMIGGTSMGSFVGGCYARENDHVSVYGRAKMLGGRLGSTWRSLIDLTYPITAIFTGKSFCHEFNRGIWKVFSDTQIEDCWISYFAVTTNLNWSRMEVHQTGYMWRYIRASMSLSGYLPPLCDHGSMLLDGGYINNLPADIMHSLGAHTIIAVDVSLADDTSPVSYGDSVSGWWMLLSKLNPFPQSYSFRPPEIADIQSRLTYISSVKQLEDAKRIDGCLYIHPPVAAYTAMDFKKFKEIVEVGYKFGQTVVQEWHNNGTLQRQLGVTLADSVERKLRGGRRASI
The following text describes a protein:
Function:
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MGRASKDKRDIYYRKAKEEGYRARSAYKLLQLHEEFGILRREEIRTGVVDLCAAPGSWSQVLSNHLCGSQPGSAAEACEGDEAINSEASQRPRIVAVDLQEMMPIDGVQLLQGDITSEWTAREIIRLLNGDSSSVPECSDATALSTAGAINDFNNGRGNNVSEEGKSSQQRSDCGVGLMNERNNASECVDGDNNNNNSNNNDDRNGGDAGASTRPVAGRKADLVVCDGAPDVTGMHELDEYLQHHLLLAALNITTFVLRRGGTFVTKMFRGPNTPFLVAKAEVFFRQVTIAKPKSSRNASMEAFMVCQNYDPPASYQPSFERPLTQTTSCFTPAAPALHLAAVDAQRMSSDNVNNGELHHSGVTDIVDEAYAVESVIVPFLACGDLTGYDADMCYDRGESDVVLPPVQPPLQAPYIAISEAVKERTKRQRVG
The following text describes a protein:
Function:
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors.
Subcellular Localization:
Secreted.
Sequence:
MLRSLSVFVLLAVACCHAEEVKSKSKICANVFCGAGRECAITEKGEPTCLCIEECKPHKRPVCGSNGRTYRNHCELHRDACLTGLKIQVAHDGHCEEKKTEKSAASPIVCYLADRNELRNRVIEWLQTEVVPDGWFSKGSNFSEILHRYFKTYDDGDSQMDSAEFLKFIQHNETAVNISSYMDEENNRLLRSLCVDALIELSDENADWKLSFNEFLNCFKPGFNPTQKKCALEDETFEDGAETQVECNRCVCACGNWVCTAMTCDGQNKKTAPLEDTDLTGQEEMTEEEWTRRVEELNKHQETVEKSKKSSTKEK
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MGLIAIACGLIVALGALGASIGIAMVGSKYLESSARQPELIGPLQTKLFLIAGLIDAAFLIGVAIALLFAFVNPFAGA
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Sequence:
MMKIYLMGSDQRIVRCARVSFAKDSYVDEKRDKRLIRYLFKHRHASPFEHNIIAFEWKKEKWIELLSKLENPTVQVYYSNGFVFLNLRNAINVWELLPDAVKERIKEAFPTTYGVIQRRGEIEDEELYSLPYTKDKAYVKEKIETSSGWIGLVDKLELETDMDFYTFVVECPLFVARQWMRHRFGSYNEVSKRYVGKEFLEFYLPKYIRKQAEKNKQASVDEPISESEVFIKKIENLISKSVKLYEEIIEKGGAKELARGVLPQFMKTRFYWTVPRISLDNFITLRTHEGAQKEIREFAEAIKEMVGYRGTDKKNVI
The following text describes a protein:
Function:
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Miscellaneous:
MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.
Sequence:
MTPALTALLCLGLSLGPRTRVQAGPFPKPTLWAEPGSVISWGSPVTIWCQGSQEAQEYRLHKEGSPEPLDRNNPLEPKNKARFSIPSMTEHHAGRYRCHYYSSAGWSEPSDPLEMVMTGAYSKPTLSALPSPVVASGGNMTLRCGSQKGYHHFVLMKEGEHQLPRTLDSQQLHSRGFQALFPVGPVTPSHRWRFTCYYYYTNTPWVWSHPSDPLEILPSGVSRKPSLLTLQGPVLAPGQSLTLQCGSDVGYNRFVLYKEGERDFLQRPGQQPQAGLSQANFTLGPVSPSNGGQYRCYGAHNLSSEWSAPSDPLNILMAGQIYDTVSLSAQPGPTVASGENVTLLCQSWWQFDTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSYSSNPHLLSHPSEPLELVVSGHSGGSSLPPTGPPSTPGLGRYLEVLIGVSVAFVLLLFLLLFLLLRRQRHSKHRTSDQRKTDFQRPAGAAETEPKDRGLLRRSSPAADVQEENLYAAVKDTQSEDRVELDSQSPHDEDPQAVTYAPVKHSSPRREMASPPSSLSGEFLDTKDRQVEEDRQMDTEAAASEASQDVTYAQLHSLTLRRKATEPPPSQEGEPPAEPSIYATLAIH
The following text describes a protein:
Function:
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MAEAALEGTEPVDLSKHPSGIIPTLQNIVSTVNLDCKLDLKAIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEQQSKLAARKYARIIQKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYSHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVLTGAKVREETYTAFENIYPVLTEFRKVQQ
The following text describes a protein:
Function:
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system (By similarity).
Sequence:
MTEEPTKENLGGPKSPTPVTMEKSPKSEVVVTTVPLVSEVQLTAATGGAELSCYRCIIPFAVVVFITGIVVTAVAYSFNSHGSVISILGLVLLSSGLFLLASSALCWKVRQRNKKVKRRESQTALVVNQRSLFA
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
Sequence:
MEKYNAIKIVKGSGGFGGPLTVKPEEGKDTLLYITGGGAEPEIVEKIVNLTGCKAVNGFKTSVPEEQIFLVIIDCGGTLRCGIYPQKRIPTINVMPVGKSGPLAKFITEDIYVSAVGLNQISLADSSAEPIKSTKVPEEGKREFKYSADKKVSQSLAENSKSSIVQKIGMGAGKVVNTLYQAGRDAVQSMITTILPFMAFVAMLIGIIQGSGFGNWFAKILVPLAGNGIGLMILGFICSIPLLSALLGPGAVIAQIVGTLIGVEIGKGTIPPSLALPALFAINTQCACDFIPVGLGLAEAEPETVEVGVPSVLYSRFMIGVPRVAVAWVASIGLYQ