lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MASLTRAVTRLAATGRQAVRSIATTTPVSGHGDDVMEKWPADKFDNHFINYLNRPEIDGWEVRKALTELHDYDVIPDPKVVEAGLRACRRVNDFALAVRFLEAIKIKCGNQKNRDSIYGYIVKQVEPTLKELGIDTPEQLGYGEPEFFVPQPEYWWEKKWYKDYGYDKQPNFQY
The following text describes a protein:
Function:
Component of the vacuole-localized DSC E3 ubiquitin ligase complex involved in the targeting of the complex to the vacuole membrane via the AP3 pathway to ubiquinate vacuolar membrane proteins. Competes with GLD1 to determine the subcellular localizations of the DSC complex.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MLHLEDDNGRQRSVIANLQKFVYCCLYLRFIKDGSLFLILLGWIISSLCDFIQELTLRYLKKNYLEVGRDNDQEDDESLAIRGLETPIVRMIINKAIRYYQGLILLETAYCIVYHIRLDVSRDICSKPYGFVIMLLIREFTCPVPTAFPSKLLLVLLDILLLFCQIVIINGSLSSSLQNVKLIVKELNAEEEGALNILKLNTWHMDATGPELIVLKNHDKSIPQQADGDDATEITPLLNIAE
The following text describes a protein:
Function:
Methylates 'Lys-14' of the large subunit of RuBisCO.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASVFSVHPLPSSSFLCPLKTTKSRTKHHQTFYTYQKTILINSLQLTELDPKIPQPVQTFWQWLCKEGVVTTKTPVKPGIVPEGLGLVAKRDIAKGETVLQVPKRFWINPDAVAESEIGNVCSGLKPWISVALFLLREKWRDDSKWKYYMDVLPKSTDSTIYWSEEELSEIQGTQLLSTTMSVKDYVQNEFQKVEEEVILRNKQLFPFPITLDDFFWAFGILRSRAFSRLRNQNLILVPFADLTNHNARVTTEDHAHEVRGPAGLFSWDLLFSLRSPLKLKAGDQLFIQYDLNKSNADMALDYGFIEPSSARDAFTLTLEISESDEFYGDKLDIAETNGIGETAYFDIKIGQSLPPTMIPYLRLVALGGTDAFLLESIFRNSVWGHLGLPVSRANEELICKVVRDACKSALSGYHTTIEEDEKLMEEGNLSTRLQIAVGIRLGEKRVLKQIDDIFRERELELDELEYYGERRLKDLGLVGEQGDIIFWEPK
The following text describes a protein:
Function:
Acts as a primer for DNA elongation during viral genomic replication. Acts as the small terminase protein during packaging. Recruits the phage DNA polymerase to the bacterial nucleoid. Primer terminal protein (TP) is covalently linked to the 5'-ends of both strands of the genome through a phosphodiester bond between the beta-hydroxyl group of a serine residue and the 5'-phosphate of the terminal deoxyadenylate (dAMP). To start replication, the DNA polymerase forms a heterodimer with a free TP that recognizes the replication origins at both 5' ends of the linear chromosome, and initiates replication using as primer the OH-group of Ser-232 of the TP. Since the polymerase initiates the replication on the second thymine, the TP-dAMP initiation product slides backwards to recover the template information of the first nucleotide; Hydrolyzes host peptidoglycans during virus entry.
Subcellular Localization:
Virion. Host nucleus. Note=Associates with the host bacterial nucleoid through its N-terminal region.
Sequence:
MARSPRIRIKDNDKAEYARLVKNTKAKIARTKKKYGVDLTAEIDIPDLDSFETRAQFNKWKEQASSFTNRANMRYQFEKNAYGVVASKAKIAEIERNTKEVQRLVDEKIKAMKDKEYYAGGKPQGTIEQRIAMTSPAHVTGINRPHDFDFSKVRSYSRLRTLEESMEMRTDPQYYEKKMIQLQLNFIKSVEGSFNSFDAADELIEELKKIPPDDFYELFLRISEISFEEFDSEGNTVENVEGNVYKILSYLEQYRRGDFDLSLKGF
The following text describes a protein:
Function:
Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Involved in DNA-damage repair in vegetative cells.
Miscellaneous:
MISCELLANEOUS: Present with 131 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly nuclear in G1-arrested cells, but cytoplasmically localized after release from G1 arrest.
Sequence:
MGVSQIWEFLKPYLQDSRIPLRKFVIDFNKSQKRAPRIAIDAYGWLFECGFIQNIDISARSRSRSRSPTRSPRDSDIDSSQEYYGSRSYTTTGKAVINFISRLKELLSLNVEFLLVFDGVMKPSFKRKFNHEQNATTCDDEKEYYSSWEQHVKNHEVYGNCKGLLAPSDPEFISLVRKLLDLMNISYVIACGEGEAQCVWLQVSGAVDFILSNDSDTLVFGGEKILKNYSKFYDDFGPSSITSHSPSRHHDSKESFVTVIDLPKINKVAGKKFDRLSLLFFSVLLGADYNRGVKGLGKNKSLQLAQCEDPNFSMEFYDIFKDFNLEDLTSESLRKSRYRLFQKRLYLYCKDHSVELFGRNYPVLLNQGSFEGWPSTVAIMHYFHPIVQPYFDEEVLSDKYINMAGNGHYRNLNFNELKYFLQSLNLPQISSFDKWFHDSMHEMFLLREFLSIDESDNIGKGNMRITEEKIMNIDGGKFQIPCFKIRYTTFLPNIPISSQSPLKRSNSPSRSKSPTRRQMDIMEHPNSLWLPKYLIPQSHPLVIQYYETQQLIQKEKEKKGKKSNKSRLPQKNNLDEFLRKHTSPIKSIGKVGESRKEILEPVRKRLFVDTDEDTSLEEIPAPTRLTTVDEHSDNDDDSLIFVDEITNSQSVLDSSPGKRIRDLTQDEQVDVWKDVIEISPIKKSRTTNAEKNPPESGLKSRSSITINARLQGTKMLPPNLTAPRLEREHSSVLDQLVTDAQDTVDRFVACDSDSSSTIE
The following text describes a protein:
Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Subcellular Localization:
Cell membrane. Cytoplasm, perinuclear region. Nucleus.
Sequence:
MSLVSQNSRRRRRRVAKATAHNSSWDEMQAPNAPGFPADMPGSDVPQGPSDSQILQGLCASEGPSTSVLPTSAEGPSTFVPPTISEASSASGQPTVSEGPGTSLLATPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSRPPTSSEEPSTSVTSVDTPDEGLSTSVPPTATEGLSTPVPPTPDEGPSTSMPATPGEGRSTSMLPAASDGQSISLVPTPGKGSSTSGPPTATEGLSTSVQPTAGEGPSTSVPPTPGEGLSTSVPPTATEGLSTSVPPTPGEGPSTSVLPTPGEGRSTSVPPTASDGSDTSVPPTPGEGPSTLVQPTASDRPGSSVLPNPGEGPSTLFSSSASVDRNPSKCSIVLPSPRVTKASVDSDSEGPKGAEGPIEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEARTYILLNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEIWEMLWRMGVQRERRLSIFGNPKRLLSVEFVWQRYLDYRPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMDWPEQYNEALEEDAARAFAEGWQALPHFRRPFFEEAAAEVASPDSEVSSYSSKYAPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQSGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFVWGPRARLETSKMKALRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQFFVHNFR
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MGIVDEFDHVAPRLRGKKEGTFAYFTVRDRWPKIVTSLVDQLTRKRDALIEKHGEDASADIADILEKFSRLRYEIMTDKPLINFPESGPDGKMWHDWMEELKTAVMPNDVEELTYFKGPWLFVECYLYRFIYSAFLATKKLADMDYFEDSKRKNFLDHLDQVEEGVAFLMKITAKDSPAHEMFGIHQIMKSSLWGNRADMSLTGGDDHTMKMSSIAASVQLKDYILIDDVNWLMVKVLAPLQANPQKLKNRRIDIVLDNAGVELCADLMMAEFFLARGFADKVVLHGKAIPWFVSDTTENDFNWTVDSLHLAGQQSAKLGEQIKKRVEKMEIIYKAGLFWISPHPYCDMQEKAPELYEELTTSSLVIFKGDLNYRKLVGDRDWDLNTSFKKAVRGFDPCPILALRTLKAETIAGLTDEVLNILLEKFDEDNSWMTSGEYAVCQLGGVPPIEE
The following text describes a protein:
Function:
RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Functions alone and as part of the erh1-mmi1 complex, to recruit the CCR4-NOT complex and the NURS complex to target RNAs. Suppresses the meiotic program during vegetative growth and promotes the meiotic program during mating. Binds to DSR (determinant of selective removal) regions in meiotic mRNA, and recruits the NURS complex to targets. Recruitment of NURS complex to target mRNAs promotes mRNA decay by engagement of the nuclear exosome, and formation of heterochromatin islands at meiotic genes silenced by the exosome. Recruitment of the CCR4-NOT complex to target RNAs promotes heterochromatin formation at RNAi-dependent heterochromatin domains (HOODs), including a subset of meiotic genes, lncRNAs and retrotransposons. Recruitment of the CCR4-NOT complex to rDNA promotes rDNA heterochromatin assembly. Promotes non-canonical transcription termination at meiotic genes and prevents lncRNA transcription from invading and repressing adjacent genes.
Subcellular Localization:
Nucleus.
Sequence:
MSNTNFSTSRSSKSIPELPNLEALRSLWPPPSLNESGDTRSVWTTHTGEPVASSVLSTSGSNNFSSPLKRPAPESHDAPIGRRLMVDDPRLIKHGKYDFSRHCTDYGHSYEWPYFRSLRRESMLYHTSGSYPESQPPYSSYSTDAPHYYHAGSESSAYYDSRSRLHGIQPPPKRRTLSPPPRRLADPVVVGSSRYVEEEVYRRPPYTLASEVPSSASAYQAGYSSYPVRSSPQLSHEDTRHGIASSGSTRYPFVPANTRASHSPSLLEPYAHSLPSSVAPVGAYPEKSSYLLSNSSNDSASRKEKPKARASTPPPLNFSRASEHRNEKGERISMINPRVVLDENGISHRSRYFIMLCDNETAIAHAKKTSIWAVKKDSSKRISDAYKKASVYFIFVAQQTYNALGYAQVVSDLNSTELPFWSDSSHAGGVRIKWIKTCNLFSAEISEIVSHMDHGSEARDGMEMMYDEGSRLCTLINYAIMKRIGRDR
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTGGDNKAEAGVRVLGGRMSPFTMRARMALELRGVAYELLEESFEPRKSDRLLAANPVYKKIPVLLLPDGRAVCESAVIVQYVDEAWPAAAGAAPLLPEDPYQRAMHRFWTAFVDDKFWPALDGASLAPTPEARAEAAAEARAALRHLEEAFAALSNGGAFFSGAAPGLLDIALGCFLPALRACERLSGAVLLDEAATPLLKKWSEWFAGVHAVKALLPETDEVVGFTRFLQAKFGVAGAN
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity).
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex; The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity.
Sequence:
MFMFNFDNGHDPNRPSFFEMLNQHQMMPSFKPALKYIFTVLSQRNPKFRYIVNYYDECFYSLLLLLEYHYLKYYEGSFSENFYNLKRIKPRNNNANGDGDTLFSLLKRLVVTPSNAGQGPETYTKSQILKKSFAMIRRNRAAASSSQQAKDDLNTMIQDSDRKESLIYLVLIPYFKGKLDEYYKKESDPLAELGLVSSDNNNNNNDNINDQIQQLEEQIQQQQTIVNGNNNSNNNNKKLKIKFLILIRFLKGSKTLKKLKTIFLKVYPFISAIYEALFFIYQLLYLYEYTNYYTPFFHFQNIQLKRLNHKDIESHRVVISNRRRDRINFVRDWPGSSFFVRLVSILDSILDYSKYILPLSVFIFKSLEWWYSENRISAPTLPIPTPPTPSKRAPGGLEIPRDKRLCPLCLKERTNPTICGSGFVFCYPCIFGYVNEHSKCPITFLPTNTEQLRKIYETV
The following text describes a protein:
Function:
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHLGSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDKRRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTANTLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLADKRLYYAKQSGRNRICASDATQEREKK
The following text describes a protein:
Function:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAGGRRAAPRCGWGWGGGWGCCPFLCLLLCCGAAGRLEVYMPAVLEVEIGSTARLECSFSIPGNASFTSIEWFYVNRRPLRSGEAVRHHASGVRIDETEYSERLSVGEDKALSISKVTRQDNARTFICQVGADSQGVGESRTELYTYKIPAPPEITPNSAGIPAQSNDMLKIAQCTSENSFPSPNITWYKNGEPLLQEEDKTKILTTLVRESNGLYTVVSTLFSKVTREDRNSLFHCTVHYWLQGQMRTKDSPRVNVTVFYPTEHVELRVATNAGIVKEGDDVKLVCDADGNPAPVFSFFRRELGDSWQDMTSLADTNDGVLMLHNVSKSSSGLYRCQTLDLDDMTQHEGDVELVVNYIEGVQVKMEPSSPLHEGDSVRLSCTAHSPVKLDYQWRDARGRKVAEGNQLLLTNLTFETSSNFSCRVKARSVPGLEQSKQVAVAVKGKPRIVAISAPLYVRQDEVINLTCKAIAFPQPSFHWSINGTTHEYMENQHMASNLTVRVSHDLLRAGAMCRVSNALGVSEKHIQLLDQKPSESKGIIIVAIIVCILVVAVLGSIIYFLHKKGKISCGRSGKQDITKPEARKDKNVVEVKSDKLSEEAGLLQGANGEKRSPADQSEKYIDLRN
The following text describes a protein:
Function:
Polymerase alpha in a complex with DNA primase is a replicative polymerase.
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MSGDNSTETGRRRSRGAEASSRKDTLERLKAIRQGGIRSASGGGYDIRLQKPIFDTVDDEEYDALVSRRREEARGFVVEDGEGGDLGYLDEGEEEDWSKPSGPESTDESDDGGRFSGRLKKKKKGKEQTQQPQVKKVNPALKAAATITGEGRLSSMFTSSSFKKVKETDKAQYEGILDEIIAQVTPDESDRKKHTRRKLPGTVPVTIFKNKKLFSVASSMGMKESEPTPSTYEGDSVSMDNELMKEEDMKESEVIPSETMELLGSDIVKEDGSNKIRKTEVKSELGVKEVFTLNATIDMKEKDSALSATAGWKEAMGKVGTENGALLGSSSEGKTEFDLDADGSLRFFILDAYEEAFGASMGTIYLFGKVKMGDTYKSCCVVVKNIQRCVYAIPNDSIFPSHELIMLEQEVKDSRLSPESFRGKLHEMASKLKNEIAQELLQLNVSNFSMAPVKRNYAFERPDVPAGEQYVLKINYSFKDRPLPEDLKGESFSALLGSHTSALEHFILKRKIMGPCWLKISSFSTCSPSEGVSWCKFEVTVQSPKDITILVSEEKVVHPPAVVTAINLKTIVNEKQNISEIVSASVLCFHNAKIDVPMPAPERKRSGILSHFTVVRNPEGTGYPIGWKKEVSDRNSKNGCNVLSIENSERALLNRLFLELNKLDSDILVGHNISGFDLDVLLQRAQACKVQSSMWSKIGRLKRSFMPKLKGNSNYGSGATPGLMSCIAGRLLCDTDLCSRDLLKEVSYSLTDLSKTQLNRDRKEIAPNDIPKMFQSSKTLVELIECGETDAWLSMELMFHLSVLPLTLQLTNISGNLWGKTLQGARAQRIEYYLLHTFHSKKFILPDKISQRMKEIKSSKRRMDYAPEDRNVDELDADLTLENDPSKGSKTKKGPAYAGGLVLEPKRGLYDKYVLLLDFNSLYPSIIQEYNICFTTIPRSEDGVPRLPSSQTPGILPKLMEHLVSIRKSVKLKMKKETGLKYWELDIRQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQGRDILQRTVDLVQNHLNLEVIYGDTDSIMIHSGLDDIEEVKAIKSKVIQEVNKKYRCLKIDCDGIYKRMLLLRKKKYAAVKLQFKDGKPCEDIERKGVDMVRRDWSLLSKEIGDLCLSKILYGGSCEDVVEAIHNELMKIKEEMRNGQVALEKYVITKTLTKPPAAYPDSKSQPHVQVALRMRQRGYKEGFNAKDTVPYIICYEQGNASSASSAGIAERARHPDEVKSEGSRWLVDIDYYLAQQIHPVVSRLCAEIQGTSPERLAECLGLDPSKYRSKSNDATSSDPSTSLLFATSDEERYKSCEPLALTCPSCSTAFNCPSIISSVCASISKKPATPETEESDSTFWLKLHCPKCQQEDSTGIISPAMIANQVKRQIDGFVSMYYKGIMVCEDESCKHTTRSPNFRLLGERERGTVCPNYPNCNGTLLRKYTEADLYKQLSYFCHILDTQCSLEKMDVGVRIQVEKAMTKIRPAVKSAAAITRSSRDRCAYGWMQLTDIVI
The following text describes a protein:
Function:
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Sequence:
MAESIVTFFLEKLTDLLSQEAFLLSRVEEQVKLLSNELEWMRLFLKDADAKRRYDPRIKLWVSQIRDVTYDAEDVIDRFMFEMNHQQQGSLKCLKFLKLRFVHKLESRIREINIKIEKIMANKSRYGVETLPAASSSNEVVPQKEKRVPIVEEVNVVGIREGAKSVKQMLLNGERRRAVVSIVGMGGLGKTTLAKKVYNDNDVQQYFDCHAWIYVSQENEAWDRLSLYVPDSMNGSRVLITSRNKEIGFHADPQTIPHELPFLTEEESWDLFLKKIFLAGSANAVCPRELEELGKKIVANCGGLPLAIVVLGGLLSRKEKTPLAWQKVLDSLTWHLNQGPDSCLGVLALSYNDMPYYLKSCFLYCGLFPEDSEIRTDKLIRLWVAEGFIQRRGKEIVEDVAEDHLQELVHRSMIQVADKSFDGRVMSCRMHDLLRDLAISEAKDTKFFEGYESIDSTSPVSVRRLTIHQGKKTNSEHLHSSRLRSFICFSECFQENILRSLYRGVKLLTVLDLESMDIYTLPEGIGELIHLKYLCLRRTRIERLPSSIGHLINLQTLDFRGTLIEIIPSTIWKLHHLRHLYGHGVVSRQSVIDNCMNGPLGVDHLTALQSLSLRAGRWCSAEGLGKLTQLRELKIRWTEIPQIMCKGFSESVEKLTALRSLYLYTTDGEETLVMPQLMPFLHHTHLYHVRLGGKLEKFPNQIEFYPPNLIQLELEYCNIKQDPMVTLEKLPNLRILQLLYSSYMGKKMVCSSGGFQRLETLKLKGLKELRELIVEEGAVPDLKVSIIASYHKMARLPRGLLQLENLQYLELFQLSHKLIEEVNQTEGEDWDKIRLITSILQ
The following text describes a protein:
Function:
Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass membrane protein. Cytoplasm. Nucleus.
Sequence:
MDEMDNVIRSLEQEYRLILLLNHRNKNQHRAASWYGSFNEMKRNCGQIITLFSSRRLQAKRLKDVEWVKLHRLLQRALFRQLKRWYWQFNGVIALGQFVTLGCTLVTLLANVRALYMRLWEINETEFIRCGCLIKNLPRTKAKSVVNDVEELGEIIDEDIGNNVQENELVITSIPKPLTENCKKKKKRKKKNKSAIDGIFG
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MAALLRKGQQLWTFMTKNNPGFDRVLEKAELAAFGGGRCIIKMTVSQEHENRMGTLHGGLTATMVDDVTTMAIISQTGQAGVSVDMNISYLKAACRGDEVIFEGICNKAGKNLAFSTAEIKLKDGTVLAMGKHTKYIGNSPKVIDFDGNCNQTLY
The following text describes a protein:
Function:
Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.
Subcellular Localization:
Vacuole.
Sequence:
MAPPLELSIPSTILSSAPNEKPYTLYNITLRLPLRTFVVQKRYSDFVTLHSALCAQVSDAPPSPLPAKTWFKSTVNSPELTEDRRRGLETYLRSIAENPDRRWRETSIWRQFLNLPSNSGNGSLSSAREGLIAANQRGVGGNAEIMADPQVWLDVHRELKAQLHDARLFLGRRDGANTAAGQYEAGANAKRCLVKAGGLLKDLEDGLKVMGEGEKNGRGEARVGAGELRRRRDLLGSAKVEKEGLEKLAVTLAIKNQASSSSGNGNAAATQADKSALFGPGVSRPSGRVLGAPVPETDKTRELDNEGVLQLQKEMMQNQDMDVEELAKIVRRQKEMGLAIHGELELQNEMLKRVDEDADRVKGKINIAKKRLGKIR
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MEVASLGWGQERLPNIFPPKRTSPWSAAAVDLPWGPSGPEKPSPSSQALCNQQADAAPVAAVGPVPTKGPLSWRPSVVGAGLQNLGNTCYVNAVLQCLTHTACQKQPFCMLCAVRAHVTRALLHPGDVIQPRKDLVASFHRHRQEDAHEFLMFALDAMQRCPSEDTLIQQIFGGCWRSQIQCLRCLGVSDTFDPYLDVTLDITAAQSVEQALRELVKGPATKRLTLHRASKVLILVLKRFTDVTGDKMDKKVRYPEHLDLQPYLSVQKAGALDYELFAVLVHSGWTCHQGHYFCYIRAGNGWWYRMDDSKVTACDTASALSQSAYVLFYIQRGELERATGGASADRAPRSPGADPIGRDAAVGEPRSPSSIRVSASEGPLAETDIQEITLEQWRRHQEHSRPKAEFNLRKVEPALPTNAVVIHRSKFGDGTGRKLPAQENCGVSTSTRDAPPEGATNMGSIPCLEGRTKSFFGVLFGFFCSVLFLAYLILVTHVA
The following text describes a protein:
Function:
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Sequence:
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP
The following text describes a protein:
Function:
Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MALFQYQALNAQGKKSQGMQEADSARHARQLLREKGLVPVKIEEQRGEVTTRSGFSLSLRRSHRISASDLALLTRQLATLVAAALPLEEALDAVAKQSEKPKLSALMAAVRAKVVEGHSLAEAMGNFPGSFERLYCAMVAAGEASGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLTLVAISVVSILLSAVVPKVVEQFIHMKQALPLSTRLLMGVSDAVRAYGPWVVLLLVLAVMGFRVLLRQEKHRLVFHRRLLFLPLIGRIARGLNTARYARTLSILNSSAVPLLQAMRISGDVLTNDYARFRLGQATDAVREGVSLHKALEQTSLFPPMMRHMIASGERSGELDGMLTRAADNQDREFSAQMTLALGLFEPLLVVSMAGIVLFIVLAILQPILQLNTLMSM
The following text describes a protein:
Function:
This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine.
Subcellular Localization:
Cytoplasm.
Sequence:
MDINTKAIKKNAFRVTKHRGKTALRVRVPGGNLPVKYFAILAKIAEEYGNGKVHVTTRQGFEIPDLDFNKMDEINKLIQPVIEGLNISQDEVGKGYSAAGTRNVTSCIGNEVCPFANYNTTKFAKRIEKAIFPNDYHVKVALTGCPNDCIKARMHDFGILGMTEPQYDKYRCVGCQACVNNCKKRATGALRFENFKVIRDHEKCIGCGECIGKCPTGAWTRSKEKYYKLAIMGRTGKKNPRLAEDFIKWVDEDSIVKIIINTYDYIHEYIDKDAPGGKEHIGYIVDRTGYQEFKKWALKDVNLKEKAELAENINWSGIKYK
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes two sequential steps of the aromatic amino acids biosynthetic pathway. In the first reaction, the AroD domain catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate; in the second reaction, the AroE domain catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MLCTTISGPSFLEAKKQILRSLKECHCFEMRVDLLSVSCLELKKLMELAPISILAWKKPESCSQADWIDKMQSLAELNPNYLDLEKDFPEEDMIRIRQLHPQIKIIRSLHTSEHTDIIQLYAHMRSSAADYYKFAVSSSSTTDLLDICHQKRSLPENTTVVCLGGMGRPSRILSPILQNPFTYARSTGSSPVAPGQFSLKHHYFYNFASLSAQSPICALIGDTSRSIGHLTHNPFFSQLGVACPYIKLPLTPQELPKFFSTIRTQPFLGVSVTSPLKTAVLPFLDKQAPSVKASGSCNTLVIRQGEIEGHDTDGEGLFSVLMQHQIPLNNQRVAIIGAGGAAQSIATRLSRANCELLIFNRTKAHAEDLASRCQAKAFSLEELPLHRVSLIINCLPPSCTIPKAVAPCVVDINTIPKHSTFTQYARSQGSSIIYGHEMFTQQALLQFRLWFPTLSFKHLEKTFIRRAAVLASLFSIAP
The following text describes a protein:
Function:
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MADMQKLVERLERAVGRLEAVSHASDMHCGYGDSAPKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPISEQIQEVITYREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSKTGPVAQELSGLPSGPSAGSGPPPPPPGPPPPPVPTSSGSDESASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPGVSPSPKPTAKKEPAVLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDVKVQVMGKVPTISINKTDGCHVYLSKNSLDCEIVSAKSSEMNVLIPTEGGDYNEFPVPEQFKTLWNGQKLVTTVTEIAG