lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTSVEQRTATAVFSRTGSRMAERRLAFMLVAPAAMLMVAVTAYPIGYALWLSLQRNNLATPNDTAFIGLGNYHTILIDRYWWTALAVTLAITAVSVTIEFVLGLALALVMHRTLIGKGLVRTAVLIPYGIVTVVASYSWYYAWTPGTGYLANLLPYDSAPLTQQIPSLGIVVIAEVWKTTPFMSLLLLAGLALVPEDLLRAAQVDGASAWRRLTKVILPMIKPAIVVALLFRTLDAFRIFDNIYVLTGGSNNTGSVSILGYDNLFKGFNVGLGSAISVLIFGCVAVIAFIFIKLFGAAAPGGEPSGR
The following text describes a protein:
Function:
This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
Subcellular Localization:
Cytoplasm.
Sequence:
MTARILIVEDELAIREMLTFVMEQHGFTTSAAEDFDSAIALLKEPYPDLILLDWMFPGGSGIQLAKRLKQDEFTRQIPIIMLTARGEEEDKVKGLEVGADDYITKPFSPKELVARIKAVLRRSAPTRLEETIDVQGLLLDPVSHRVSVGDTVLDMGPTEFRLLHFFMTHPERVYSREQLLDNVWGTNVYVEDRTVDVHIRRLRKAVEESGHDRLIQTVRGAGYRFSTRS
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MNYPSVSEQKHRVFIIYSAYLRVQFRESARLAVSVRNKNYNLVRADLHNILPQKNTTVFKDGTLAPLLIRLAWHSCATYDKYTRTGGSNGATMRYHLEASDEGNVGLEVARLSLEPIKRKHPWITYADLWILAGVVSIEACKGPSIKWRDGRVDYEDDLLVPPNGRLPLGGGDASHVRTIFSRMGFNDQETVALIGAHSLGRLHHHRSGFDGPWTSNPAKCDNEFYKLLLGNVWTLVDSPTGRKQYVNSTGQVMMPSDMSLIEDANFRFWVDQYAVSEELWRDHFALAFEKLTELGR
The following text describes a protein:
Function:
In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MGPAPMAFHNKDVGPLSPSPWDAILEAVREQLPSLDSDSSLSDCEEEELFIFQRDQTTLIPDLSEELAEDCAGPWVTPSGFPPEPAVHVEPTPEPWRDYSPRLRESASLEGRAPGGPLQSCGQSSSHLRMPVEAAAWQEDEGGKSFNTSASQSGSQGPQGQATLPPGEAALQTEGPGAASGAPAGSDSTNHRSLRRERRKMIERDILHKVTRSARHPACQDPSPVEETPRDTAEKPPEGPQRGLPMRSLQQLEEWDLDQVLQSLTGREDDQGDGTPGATCWAADHLEGQDHAEPSTQDRLMERLVLLCARQSRASPSARRAPADTPQDKQQEAGSRCISRELGFQTLAENMRLRGPAEPPSIFIDLRPTKPSDQGSLDSSSSSSSNSEEEEEEEAAAQRDPKGPMRLRDCTGKSQLLQQLRAFQKATAEPQLPAGKDPSNQKAQGPGDTAGSSPVEKQHCTLWAERQSTQARHPEGSLGALGDPLGAGPAREDLVPALGQL
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNKEQELAEAGRFVRRFFELLDTNPAELTSMFDNESSVFIYGRENGTTVGVDGIVGKLTALSSKGCTHKITTMDSLLCEREDRGILVSVNGRLKVDGFDHDLVFSQMFFLKTKGQSFYVRTGVYRLKYLLERVRIQGF
The following text describes a protein:
Function:
Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted.
Sequence:
MLQDPDSDQPLNSLDVSPLRKPRTPMETFRKVGIPIIVALLSLASIIIVVVLIKVILDKYYFLCGQHLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDPATGNWFSACFDNFTAALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELHVRNSSGPCLSGSLVSLHCLACGESLKTPRVVGGKEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQLPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSIRCNADDAYQGEVTEKMVCAGIPEGGVDTCQGDSGGPLMYQSDQWQVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVRKAEL
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAINVGKANLVEQLELILSLRGSYPIVAIDTEFPGFIRDTPRNATEEERYNDVKHNVDNMHLIQLGVALFDEGGNTPWPGCCWQFNFSDFDPDVDASSPDSIELLVIWDLSERNSELCRQLEEVRVGSGPEAVAAAEKHATDSEEEVARLRAELEQSGDSVKELQEFLRLDRAELRLLKSEALGLAKRAEKVEAEARAASDALAEEVRLRPSKDKEAIEAYKRSENFELGLTRMGRVSYEYGYRITLGRFCSCPPGSEVEKDPFASHPVDLEVDMPEDVPFDDRPKTPGE
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake.
Miscellaneous:
MISCELLANEOUS: The DctPQM carrier is more efficient than the DctA carrier for the utilization of succinate at micromolar concentrations, whereas DctA is the major transporter at millimolar concentrations.
Subcellular Localization:
Periplasm.
Sequence:
MLKHTAKALVCALSLTVAGIVQAADPIVIKFSHVVAEHTPKGQGALLFKKLVEERLPGKVKVEVYPNSSLFGDGKEMEALLLGDVQIIAPSLAKFEQYTKKLQIFDLPFLFDNIQAVDRFQQSPQGKELLTSMQDKGITGLGYWHNGMKQLSANKPLREPKDARGLKFRVQASKVLEEQFKAVRANPRKMSFAEVYQGLQTGVVNGTENPWSNIYSQKMHEVQKYITESDHGVLDYMVITNTKFWNGLPEDVRGVLAKTMDEVTVEVNKQAEALNQGDKQRIVEAKTSEIIELTPEQRAEWRKAMQPVWKKFEGEIGADLIKAAEAANQAQ
The following text describes a protein:
Function:
May play a role in female meiosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSELSELELLSQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICTGTVCE
The following text describes a protein:
Function:
Class II ribonuclease (RNase) (By similarity). Binds to cytokinins (By similarity). Interacts with melatonin (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGVFTFEDESTSTIAPARLYKALVKDADAIIPKAVEAIQSIETVEGNGGPGTIKKLTLIEGGETKYVLHKIEAVDEANLRYNYSIVGGVGLPDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIENYLSAHPEYN
The following text describes a protein:
Function:
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylserine and small amounts of ethanolamine from the lumen to the cytosolic leaflet of the trans-Golgi network and ensures the maintenance of asymmetric distribution of phospholipids. Required for the formation of transport vesicles from endosomes.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Sequence:
MVSLFKRGKAPPLTKEGPTSKKPPNTAFRQQRLKAWQPILSPQSVLPLLIFVACIFTPIGIGLIVSATKVQDLTIDYSHCDTKASTTAFEDIPKKYIKYHFKSKVENKPQWRLTENENGEQSCELQFEIPNDIKKSIFIYYKITNFYQNHRRYVQSFDTKQILGEPIKKDDLDTSCSPIRSREDKIIYPCGLIANSMFNDTFSQVLSGIDDTEDYNLTNKHISWSIDRHRFKTTKYNASDIVPPPNWMKKYPDGYTDENLPDIHTWEEFQVWMRTAAFPKFYKLTLKNESASLPKGKYQMNIELNYPISLFGGTKSFVLTTNGAIGGRNMSLGVLYLIVAGLCALFGIIFLVKLIFQPRAMGDHTYLNFDDEENEDYEDVHAENTTLREIL
The following text describes a protein:
Function:
Sodium channel (Nav) specific neurotoxin. Causes impairment of movement and mild paralysis in crickets at a dose of 0.5 ug per animal. A dose of 0.8 ug per cricket causes clear flaccid paralysis. A dose of 1.0 ug per cricket causes death within 2 hours. Is not toxic to mice at a dose of 100 ug per 20 g mouse weight.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
MKTIPLLFLLFIYFECDGKFIRHKDESFYECGQLIGYQQYCVDACQAHGSKEKGYCKGMAPFGLPGGCYCPKLPSNRVKMCFGALESKCA
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MASHGIPRVATTEQKSIAVQEKERKDIEEYKALVQLIELKAEVLTTTLGDPHHPTPGKNSTILDLIQADLDFIFPLMLGWPKCYWIWNYRLWLLKQANDRLTADIARGLWQRELVLVGKMLTRDSRNFHGWGYRRTVVSQLEGPNLNSPSMVESEFAYTTRMINAELKNFSAWHNRSKLILRMLKERQATAIERRQFLDDEFDLITKAMWNDAYPYDQSVWFYHQFLMSNLTESVGHASIAPDFSREDRIEYIKKQLVNLKDFLDGGEDCKWVYDALFEYTLAVCEMEERLPERDEIQDCKAWLSELRKLDPMRAGLKPSKYPIPCASKSNEEQRVSGPYDIHEKAEAGVEECEKQQEERSGRCFAEAGV
The following text describes a protein:
Function:
In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.
Subcellular Localization:
Late endosome. Lysosome; [Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted.
Sequence:
MELPLSQATLRHTLLLLPALLSSGQGELAPQIDGQTWAERALRENEHHAFTCRVAGGSATPRLAWYLDGQLQEATTSRLLSVGGDAFSGGTSTFTVTAQRSQHELNCSLQDPGSGRPANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPPANVTWIDQDGPVTVNASDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTSASLPAPGLLATRIEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSLISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDLRGKATERPMAQHSSRPELLEAEPGGLLTSRGFIRLPMLGYIYRVSSVSSDEIWL
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Domain:
The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested; The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
Sequence:
MTWAPDNVRKWSALLLLAIIGTALTAATDPGFVAMISQKGLDFACQQGVVELQKELQAISVPDFSGVFKIKHLGKGSYEFYSMAVDGFHIPNPKIEMLPSDGLRVFIKDASIKINGKWMSRKNFLKAGGNFELSIQGVSISTDLILGSDSSGHITTICSNCDSHIDSVHIKISGSMLGWLIRLFHRKIETSLKNIIYKKICKIVRDSVSSKLQPYLKTLSVITRVDDVTSVDYSLLAPLTTTNQFLEGQLKGEFFWRGHRDPLPIHPPVMRFVPNGAYMVCMGISDYFFNTEVLAYQQSGTLKMTLGGQLLSNNGRFQLNTDFLRTFLPKVAKMFPSMGVQLLISAPVPVHLSIQPSGLSFNPKLETQAFVVLPNASLVPLFVLGMKTNASLEVDAEENRLVGEMKLGSRWLLELKESKFGPFKVEYLEDVINYLVSTLVLPKINERLRRGFPLPLPAGIRFSHFTFYPYQNFLLLEADLHLI
The following text describes a protein:
Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Sequence:
MGSRNSSSAGTGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQGGGAANLQLIQALSDSEEEHDSAWDGRLGDRYNPPVDATPDTRELECSEIKTQVELATGRLGLRRAARELSFPQMLHQRERGLCHQGSFSLGERSRVMSHFLPNDLGFTDTYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADVSSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPTHSTGQQFIYSGCSTGKVVVYDLLSGHVVKKLTTHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEEHPSTPAPMSHPSTAFSSPQ
The following text describes a protein:
Function:
Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. MxiH/SctF forms the external needle filament that protrudes from the bacterial surface; During infection, can induce innate immune responses. The needle proteins interact with host TLR2 or TLR4, and induce signaling by NF-kappa-B and/or AP-1. This activation is MyD88 dependent and results in increased expression of cytokines, including TNF-alpha, IL-6 and IL-8.
Subcellular Localization:
Secreted. Cell surface.
Domain:
The helical filament defines an inner channel with about 20 Angstroms diameter and has an outer diameter of approximately 70 Angstroms. Deletion of the last five residues prevents self-association and yields monomeric proteins that allow biophysical studies.
Sequence:
MSVTVPNDDWTLSSLSETFDDGTQTLQGELTLALDKLAKNPSNPQLLAEYQSKLSEYTLYRNAQSNTVKVIKDVDAAIIQNFR
The following text describes a protein:
Function:
Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates include SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6, ATF6B and FAM20C. Cleaves substrates after Arg-Ser-Val-Leu (SREBP2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Also mediates the first step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. Cleaves the propeptide from FAM20C which is required for FAM20C secretion from the Golgi apparatus membrane and for enhancement of FAM20C kinase activity, promoting osteoblast differentiation and biomineralization. Involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. It is required for the activation of CREB3L2/BBF2H7, a transcriptional activator of MIA3/TANGO and other genes controlling mega vesicle formation. Therefore, it plays a key role in the regulation of mega vesicle-mediated collagen trafficking. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the first step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=May sort to other organelles, including lysosomal and/or endosomal compartments.
Sequence:
MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAFNGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDHPNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
The following text describes a protein:
Function:
Major protein in sweat, has surfactant properties. Has a role in temperature regulation by having a capacity to make hydrophobic surfaces wettable and so can function in promoting spreading and evaporation of sweat.
Subcellular Localization:
Secreted.
Sequence:
MLKVSCLFVLLCGLLVPSSAQQIPPEVSSQITDALTQGLLDGNFLSLLNAINLEGLLNTILDQVTGLLNILVGPLLGPSDAEIKLQDTRLLQLSLEFSPDSKGIDIWIPLELSVYLKLLILEPLTLYVRTDIRVQLRLESDEDGKYRLAFGHCSLLPRAIELQSGNPLSLPVNAVLGTIENALGNFITEDLGAGLCPTLNSLVSNLDLQLVNNLINLILDRANVDLSV
The following text describes a protein:
Function:
Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan and glucan biosynthesis. Regulates quorum sensing as well as hyphal formation, biofilm formation, chlamidospore formation, and virulence. Plays a prominent role in phagocyte activation. Involved in the covering of the most potent pro-inflammatory cell wall molecules, the beta-glucans, underneath a dense mannan layer, so that the pathogen becomes partly invisible for immune cells such as phagocytes.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MSMNFFNSSEPARDHKPDQEKETVMTTEHYEFERPDVKAIRNFKFFRSDETETKKGPNLHISDLSPLESQSVPPSALSLNHSIIPDQYERRQDTPDPIHTPEISLSDYLYDQTLSPQGFDNSRENFNIHKTIASLFEDNSSVVSQESTDDTKTTLSSETCDSFSLNNASYLTNINFVQNHLQYLSQNVLGNRTSNSLPPSSSSQIDFDASNLTPDSIPGYILNKKLGSVHQSTDSVYNAIKIPQNEEYNCCTKASASQNPTNLNSKVIVRLSPNIFQNLSLSRFLNEWYILSGKHSSKEHQIWSNESLTNEYVQDKTIPTFDKESARFRPTLPINIPGILYPQEIINFCVNSHDYPLEHPSQSTDQKRFAMVYQDNDYKTFKELSMFTLHELQTRQGSYSSNESRRKSSSGFNIGVNATTTEAGSLESFSNLMQNHHLGATSTNGDPFHSKLAKFEYGVSKSPMKLIEILTDIMRVVETISVIHELGFVHNGLTSSNLLKSEKNVRDIKITGWGFAFSFTENCSQGYRNKHLAQVQDLIPYMAPEVLAITNSVVDYRSDFYSLGVIMYELVLGILPFKNSNPQKLIRMHTFENPIAPSALAPGWISEKLSGVIMKLLEKHPHNRYTDCHSLLHDLIEVKNMYISKLLDSGETIPNSNLNLSDRQYYLTKENLLHPEKMGITPVLGLKESFIGRRDFLQNVTEVYNNSKNGIDLLFISGESGRGKTIILQDLRAAAVLKQDFYYSWKFSFFGADTHVYRFLVEGVQKIITQILNSSEEIQNTWRDVILTHIPIDLSILFYLIPELKVLLGKKYTSIYKHKIGMGMLKRSFKEDQTSRLEIKLRQILKEFFKLVAKQGLSIFLDDVQWCSEESWRLLCDVLDFDSSGEVRESYNIKIVVCYALNADHLENVNIEHKKISFCRYAKQSHLNLREFSIPHIPLEDAIEFLCEPYTRSHDHECNSKKSDVIANLNCTNEYPQNTCKVIPSIIQELYQSSEGNVLLLIFLTRMTKLSGKVPFQRFSVKNSYLYDHLSNSNYGTTRKEILTNYLNMGTNSDTRALLKVAALISNGSGFFFSDLIVATDLPMAEAFQLLQICIHSRIIVPTSTYYKIPMDLIASDQTPFDLTDDNIWKLATLCSYKFYHDSICTHIIKELNASGEFKELSRLCGLRFYNTITKERLLNIGGYLQMATHFRNSYEVAGPEENEKYVEVLVQAGRYAISTYNMKLSQWFFNVVGELVYNLDSKTQLKSVLTIAENHFNSREFEQCLSVVENAQRKFGFDRLIFSIQIVRCKIELGDYDEAHRIAIECLKELGVPLDDDDEYTSENSLETCLGKIPLSVADIRGILKIKRCKNSRTLLMYQLISELIVLFKLQGKDKVRRFLTAYAMSQIHTQGSSPYCAVILIDFAQSFVNETTTSGMLKAKELSIVMLSLINRAPEISLSYVQSIYEYYFSCHAVFFESIEKMSDLIHPGNASSHCTRSSYYSSFHLIVNVSKIFFSCMNGESFKMFSTFKCKSYLTGDPQMPEMDNFLYDSEMLLAGHSELNEFMRKYQSFNQTSVGKFCYYLIVLLVMSREHRFDEAADLVLKVLEDLSEKLPVSFLHHQYYLICGKVFAYHQTKTPESEEQVERILARQFERYELWASTNKPTLLPRYLLLSTYKQIRENHVDKLEILDSFEEALQTAHKFHNVYDMCWINLECARWLISINQKRHRISRMVKQGLKILRSLELNNHLRLAEFEFDEYIEDEDHRNKWAGLTNNPTLDTVTTWQQQNMPDKVSPCNDKQLVHGKQFGKKEFDSHLLRLHFDGQYTGLDLNSAIRECLAISEALDENSILTKLMASAIKYSGATYGVIVTKKNQETPFLRTIGSQHNIHTLNNMPISDDICPAQLIRHVLHTGETVNKAHDHIGFANKFENEYFQTTDKKYSVVCLPLKSSLGLFGALYLEGSDGDFGHEDLFNERKCDLLQLFCTQAAVALGKERLLLQMELAKMAAEDATDEKASFLANMSHEIRTPFNSLLSFAIFLLDTKLDSTQREYVEAIQSSAMITLNIIDGILAFSKIEHGSFTLENAPFSLNDCIETAIQVSGETILNDQIELVFCNNCPEIEFVVGDLTRFRQIVINLVGNAIKFTTKGHVLISCDSRKITDDRFEINVSVEDSGIGISKKSQNKVFGAFSQVDGSARREYGGSGLGLAISKKLTELMGGTIRFESEEGIGTTFYVSVIMDAKEYSSPPFSLNKKCLIYSQHCLTAKSISNMLNYFGSTVKVTNQKSEFSTSVQANDIIFVDRGMEPDVSCKTKVIPIDPKPFKRNKLISILKEQPSLPTKVFGNNKSNLSKQYPLRILLAEDNLLNYKVCLKHLDKLGYKADHAKDGVVVLDKCKELLEKDEKYDVILMDIQMPRKDGITATRDLKTLFHTQKKESWLPVIVALTANVAGDDKKRCLEEGMFDFITKPILPDELRRILTKVGETVNM
The following text describes a protein:
Function:
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum.
Domain:
The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Sequence:
MFPEQQKEEFVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDIEACVSGQTKYSVEEAIHKFALMNRRFPEEEEEGKKDADVEYDSESSSSGLGHSSDDSSSHGCKTSPALQES
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSFNKKGRDDLMQITNDEDGREINPHMPQYIINAPWYLKESTPSLKHQRIRKQQNTSTFDNWYQRGSKGPNNLKFKKGACTNCGSTTHQSKDCCERPRQIGAKFSNTDIQPDDLVSNVQGLNYDAKRDRWNGYDPETYKSQIQEYEILEEKRKETRLQEGQQTESGNLDDEFKDNGTGEHQTQMTTRDPRTKTMTRNLRIREDKANYLLNLDVNSAYFDPKSRSLRENPNPHLPPEKQVFKGLNQIRLTGETLQMYEQERFAWQYAEQHNLNLNTVSLPTLTEKTYKQIKAKKEEQKIGRAESLFDRYGGEEHLNPQMDLLLGQTERFVEYEEDGLPKNPLKKKDLTKSKYLEDFFYGDHTSVWGSWWSDVLGWGYDCCYSNEKHSVCLGEKGRRLQLNKEARLKREIEEEIQKAQTQDQKSSPQHQHQQPQQQIIQQVQQQ
The following text describes a protein:
Function:
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
Miscellaneous:
MISCELLANEOUS: DPOLM has a reduced ability to distinguish dNTP and rNTP as substrates, and elongates them on DNA primer strand with a similar efficiency. It is able to polymerize nucleotides on RNA primer strands (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLPKRRRVRAGSPHSAVASSTPPSVVRFPDVAIYLAEPRMGRSRRAFLTRLARSKGFRVLDAYSSKVTHVVMEGTSAKEAICWQKNMDALPTGCPQPALLDISWFTESMAAGQPVPEEGRHHLEVAEPRKEPPVSASMPAYACQRPSPLTHHNTLLSEALETLAEAAGFEANEGRLLSFSRAASVLKSLPCPVASLSQLHGLPYFGEHSTRVIQELLEHGTCEEVKQVRCSERYQTMKLFTQVFGVGVKTANRWYQEGLRTLDELREQPQRLTQQQKAGLQYYQDLSTPVRRADAEALQQLIEAAVRQTLPGATVTLTGGFRRGKLQGHDVDFLITHPEEGQEVGLLPKVMSCLQSQGLVLYHQYHRSHLADSAHNLRQRSSTMDAFERSFCILGLPQPQQAALAGALPPCPTWKAVRVDLVVTPSSQFPFALLGWTGSQFFERELRRFSRQEKGLWLNSHGLFDPEQKRVFHATSEEDVFRLLGLKYLPPEQRNA
The following text describes a protein:
Function:
Could be involved in undecaprenyl phosphate (UndP) transport and recycling. When expressed in B.subtilis uptA-ykoX double mutant, confers high-level resistance to the amphomycin derivative MX2401, which binds UndP in the outer leaflet of the cytoplasmic membrane and prevents its transport across the membrane and its recycling.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDLIYFLIDFILHIDVHLAELVAEYGVWVYAILFLILFCETGLVVTPFLPGDSLLFVAGALASLETNDLNVHMMVVLMLIAAIVGDAVNYTIGRLFGEKLFSNPNSKIFRRSYLDKTHQFYEKHGGKTIILARFVPIVRTFAPFVAGMGHMSYRHFAAYNVIGALLWVLLFTYAGYFFGTIPMVQDNLKLLIVGIIVVSILPGVIEIIRHKRAAARAAK
The following text describes a protein:
Function:
Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Sequence:
MKRLLFLLGLLLVVSPPVWCQDEGEGIPNPDDDDEVQYNTTYAEDQTKLQMAIFRNYNRNNRPVVKDDDSTEVELHLHVTHVSFNQREQTMTVHGHMYMTWLDETLFWDPKDYGGVTTTNVKKWQIWMPELRVTNSVNGIYSMHEISRNAHITVQTLTTDGKTYTKSRVETYPTFSMKVGCLMDFSDYPYDVHYCGVRLYTPKKINQVKLRVYKGMAPTMFLSWSNESQKLTSGDFTINRASNNISWYRYGVTDDLEPLTGKDGAKTWSIYNMYIFYARHSASYFVTIALPLFSATVISIMSFLIKELQFATIINGTTFILHILFIGEFMKICPVSVFDVPRALLFHGYSMGLTMFAFAFHAFLCIACGSRSIQNYMIDGYSKAWSVIPFNPFPGFMDGFVKGLGDIRGRGWHRNMFIWRVETFFILSVLYLILFTRAFLI
The following text describes a protein:
Function:
FMRFamide-like neuropeptides. Stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss. Together with atfs-1, negatively regulates the expression of the transcription regulator hlh-11, to promote expression of atgl-1, and thus atgl-1-dependent fat oxidation in response to mitochondrial stress; TPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro; SPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro; [SPMERSAMVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro; [SPMDRSKMVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro.
Subcellular Localization:
Secreted. Note=Secreted from the ASI sensory neurons in response to serotonin or octopamine.
Sequence:
MLGSRFLLLALGLLVLVLAEESAEQQVQEPTELEKSGEQLSEEDLIDEQKRTPMQRSSMVRFGRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMERSAMVRFGRSPMDRSKMVRFGRSSIDRASMVRLGKRTPMQRSSMVRFGKRSMEFEMQSNEKNIEDSE