lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MGQKDCEKSQNGAGGSETLCVVGEGRHKKPEMEERGQWSNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTSQGGVTAWRKICPLLEGIGYASQVIEGYLNIYYIVILAWALFYLFSSFTSELPWATCNHTWNSENCVDFVGKSENYTALKNSTSPVVEFWENRVLHLSDGIEHLGNVRWDLALCLLLAWIVCYFCIWKGVKSTGKVVYFTATFPYVMLIILLVRGVTLPGAYDGIIFYLKPDISRLQDPQVWMDAGTQIFFSYAICQGCLTALGSYNKYNNNCYRDCMALCFLNSITSFVAGFAIFSVLGFMAREQGVPISEVAESGPGLAFIAYPKAVTMMPVSPLWACLFFLMLIFLGLDSQFVCVESLVTAIVDMYPQVFRKKYRRELFILAVAVICYLLGLILLTEGGMYVFQLFDYYAASGTCLLFVAIFEVVCVGYVYGANRFYDNIEDMIGYRPWPLVKYCWLFATPAVCMGTFLFSLIKYSPLKYNNRYVYPSWGYAIGWLMALSSMICIPVYAFYIIFRTKGSFKQRLKQLVTPNTDLPQPKKYLTARADSKQIEVLGLEAKDGLIVSNKETQF
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKSKQNKEDLKKRKYESSDDSSSSDSSDDDSNKLNNNKNLNKKKKIIESDGNSSDSESNKNKNKNKKDSSSSSDSDSSSSSDSSSDSSSSDSSSSESSDSEKETLTNKKQENNGTDSSDSDSDSSDDEKDKSKKMKKESDSSDSDSDSDSSDSDSDNDNKKQKKNNSDSDSDSDSESSNNKDKESNSDSDSSSDSDSDSDSKDSDKESNNSDNEPIEEKEDEVLMDISNKEIDLNEITEDLLNLLLGKNSNGITSTLNYPNKKRISKKAKEEEEKDYFIDKSSILSTRLLLLIKKTLSLQNNTPVSSSSISTLINQLSFSLSNNSNNPVSTYNDLSLWKDIQKNNQKTLNEIEDIKQNNDKKETNINNNSNNNNSNNKINKNFREFFVERMTNQFGDDLDKLRDDPYYKDSMLTMILESMESGIDLYTTQDKLLLLKSLKK
The following text describes a protein:
Function:
Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that is required for the proper transport of proteins in post-Golgi trafficking pathways to the growing cell plate in mitotic active cells. Required for the polarized and selective transport of PIN2, but not PIN1, to the plasma membrane. Not required for ER-to-Golgi as well as biosynthetic and endocytic vacuolar transport.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Early endosome.
Sequence:
MANYLAQFQTIKNSCDRLVAAVEDVCDLWPTVKGLFEEHQPLKRAFLTNKTRNPVFVENLPVEFILTTDARLRSRFPQEQYLFWFREPYATIVLVTCEDLDEFKNILKPRLKLIVQNDEREWFIVFVSKAHPSNDQATKNVKKVYAKLEVDFSSKKRERCCKLDVHGPEGNFWEDLELKITECIRNTLDRRAQFYEDEIRKLSEQRFMPIWNFCNFFILKESLAFIFEMAHLHEDALREYDELELCYLETVNMPGKQRDFGGFDGEDDQAVLLKPGSKPLTQIVQDDSFREFEFRQYLFACQSRLLFKLNRPFEVASRGYSFVISFAKALTLHESVLPFCMREVWVITACLALIEATASHHHDGVVAPDIEKEFFRLQGDLYSLSRVKFMRLGYLIGYGTDIEKSPLNSACLSMLPWPKPAVWPSLPQDASSEVLEKEKTILQATSRTKHFGIQRKALPLEPSVLLRVANRRRASLSTGNIPEMFDGRPSFTEGSGLEASPRTPSSLKVQAPPMSRTNSSPGNFESPLDRPMRLAEIFVAAEHALRLTISDHDLLKTLSSIQDFENKYLNLTKGAAENYHRSWWKRHGVVLDGEIAAVCFKHGKYDLAANSYEKVCALYAGEGWQDLLAEVLPNLAQCQKILDDQAGYMSSCVRLLSLDKGLFSSKERQAFQSEVVTLAHSEMKNPVPLDVSSLITFSGNTGPPLQLCDGDPGNLSVTVWSGFPDDITLDSLSLTLVATNNTDEGGQALKSSAATVLNPGRNTITFALPPQKPGSYVLGVVTGQIGRLRFRSHSFSKGGPADSDDFMSYEKPTRPILKVSKPRALVDLAAAVSSALLINEAQWIGIIVRPIAYSLKGAILHIDTGPGLKIEDSYGIEMERYMDADCDTGASKAEVFVEDSPVSSKRDSEVLNLCDGKIVFSDWASNVSSILWVPVRALSEKLARGSSSVTPLKQDILEGMRTVALKLEFGVHHNQIFERTIAAHFTDPFDVTTRVANKCNDGTLVLQVMLHSLVKANLIVLDVWLDLQDGFIHGQNDGRPTSTFFPLVVSPGSRAAVVFSICLDKSMSSEGKDLQLPESILNIKYGIHGDRAAGAHRPVDADHSETDTEGRDLVFKSAIVLQRPVLDPCLTVGFLPLPSDGLRVGKLITMQWRVERLKELKESEAVEQQHDEVLYEVNANSENWMIAGRKRGHVSLSEEQGSRVVISILCVPLVAGYVRPPQLGLPNVEEANVSSNPSGPHLVCVLPPLLSSSYCLPVK
The following text describes a protein:
Function:
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIIVNREQFRAHKTVLMACSGLFYSIFTDQLKCNLNVINLDPEINPEGFCILLDFMYTSRLNLRENNIMAVMATALYLQMEHVVDTCRRFVKSSEAEMVSAVKTPREEFLAGRMLNHPEVMAYRGRDVSENSMPLQNGSLCNGRAFAPGLFNSLPGSSISYPGYSPLPLNGFLVDDELREMRMPLSELSRVSAFPKERIPCDGSRTIPAEYMRTITDISANMCHATIYSPKEGAAEEARSDMHYSVASGPKPVVPSIRNNPYFSCDKVAKEEERTSSEDEISQHFEPTNTPLDRKGLISPQSPQKSDCQPNSPTESSSSKNARISQNSNSLFTKSPTDPKACNWKKYKFIVLNSLNQSTKQDSADQNEMGTLSPRTYMPMSTCQQSMEPEHLNVQSPTKMSVNGEDSNIPQASRLNNIVNRSRDGSPRSSEGQSPLYMHSSKCSSCGCQSPQHTEMCLHTSGSAFGEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHSLQVHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRISANEVPPELPKAC
The following text describes a protein:
Function:
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Sequence:
MEAKAVSRFVRMSPRKVRLVADEIRGYAVNEALDILKFTNKRAIEPLTKVILSASANASVLNNKVDFNQLFIKKIYVDEGPIMKRFRPRARGRAARIRKRLSHITVVLSD
The following text describes a protein:
Function:
Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MSVTPVLDPEWQRSPEGLDYLSRVLRHNKRKFFGLIERPVLPPHLPADVAAYKVFVCGKSGVGKTSFIAKLSGLAVPSMHHETAGIQTTCMYWPVRPSGSARPVIFRFQFWDCGEGALRKFDHILPACKEKADAVLFLFSFTDRSSFEDVPALISRTLDQDEDVTRVVIGTKLDQYMHTDVTEDDLRDFQRTWQLPVMRVRSVNGPRMTDGRDLDGRAGLAECAPVLNGLAEILWHRDQVIAGLVGGAE
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MDDEQNIYKESTQNIPFLQWLNQKKSNVFSQLYNYIPNNYTSPQLYPNEFIIFLGELFPPHIVRTETSNFFDVAITHIKAYPALTSLIYFVYRSNFSALPNTSLTSDGGWGCTIRACQMLLANAIIKLFGSDNINRKTVIHWFLDFYNSECPYSIHSLFTTQIIVSGNPNGSSFLPFSSVIYALTELVNKDFNRAFECHVITNKFLLKSINKPTIVFIPFTIPDKFDQRLITIFSFNLFAGMVGGSKQKAFYFFGIHHNQLLFLDPHFVRPCASSIMKFDEKDYIAKLSDIKSLRINELERSVVFSFVIHSFQELISLQELAKNVLGIDDKQLTIKREECDGFEVLEF
The following text describes a protein:
Function:
Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin (By similarity). Associates with membranes via the adapter protein complex AP-1. Colocalizes with AP1G1.
Domain:
The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2.
Sequence:
MALRPGAGASGAAGAGTGPGGAGSFMFPVAGGMRPPQGLIPMQQQGFPMVSVMQPNMQGMMGMNYSSQMSQGPIAMQAGIPMGPMPAAGVPFLGQPPFLGMRPAAPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKNRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPDCPTSSHSTKTVSPSSAFLGEDEFSGFMQGPVELPTCGPSSTAQPFQSFLPSTPLGQLHTQKAGAQPLPPGQAPVSFAVHGVHGQIPCLSAASASHSMQKAGPSLEEKLLVSCDISASGQEHIKLSSPEAGHRAVVPGSSKNSPGLMAHNGGAVDGCVSGPTTAVAEKTSDQNLSKEESGVGVFPSQDPVQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMVAVTQRGVPAMSPDTLNQFPAAPIPTLSGFPMTLPTPVSQPTAMTSGPAGSIPLSLGQPIMGINLVGPVGGAAAPTSSGFMPAYPSNQVGKTEEDDFQDFQDASKSGSIDDSFTDFQEVPASSKTSNSQHGNSAPSLLIPLPGTKASTDKYAVFKGISAEKPSENPASFGESGDKYSAFRELEPTADSKPLGESFAEFRSTGTDDGFTDFKTADSVSPLEPPTKDSFPSAFASGAAQQTQTQVKTPLNLADLDMFSSVDCSGEKPVPFSAAFSTSKSVSSRPQPAGSAAAPASLASTKASSLADDFGEFNLFGEYSNPASVGEQDDFADFMAFGNSSIPSEPKADDKYEALREEGSPGALSTSTVEGAHNPPVSSSKYDVFKQLSLEGAGLAIEEFKENTPSTKSDGDFADFHSSKFSSTSSDKSLGEKAVAFRHAKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAAGSALASEDALPETPFPAFASFKDMMPQTTEQKEYESGDFQDFTRQDMPMVDRSQENTCPSPASSVASHETPKEGADDFGEFQSEKPKISKFDFLVANSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLSERAALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALDVIKKANDTLNGISSSAVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLTTLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEETPAEEQPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLLLPDLL
The following text describes a protein:
Function:
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable).
Subcellular Localization:
Nucleus.
Sequence:
MEVETTEPEPDCVVQPPSPSDDFSCQMRISEKISPLKTCFKKKQEQKRLGTGTLRSLRPILNTLLESGSLDGVFRARDQNRDESSLHEHIVKKPLEINPSCPPAENSMPVLIPDGTNVEGQLPEAHPSTDAPEQGVPIQDHSFPPETISGTVADSTTGHFQTDLLHPVSGDVPTSPDCVDKVMDYVPGAFQDNSFTIQYILDTSDKLSTELFQDKSEEASLELVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVSNDSQEHLERFYCNPENDRMRMKYGGQDFWADLNAMTVFETTEFDQLRRLSTPPCSNSNSIYHTFWKFFCRDHFGWREYPESVVRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILIPYLQTLGGVPTQASLPLEATSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMSGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid. Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways. May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism (By similarity). Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Note=Post-translationally targeted to mitochondria. All three of the receptor proteins in the TOM complex, TOMM70, TOMM20 and TOMM22 are required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein.
Sequence:
MAAWSRTRLRWTLLDPRVVGRGLCPQGARAKATIPAALQAQESTEGPGTGQDRPRLRSPAELPGTGTLQFLFQLFLQGYVLHLPDLQVLNKTKYGPMWTTSFGTYTNVNLASAPLLEQVMRQEGKYPIRDHMDQWKDHRDHKGLTYGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVISDFITRLDQVRAESESGDQVPDMAHLLYHLALEAITYILFEKRIGCLKPSIPEDTAAFIRSVAIMFQNSVYITFLPKWTRPLLPFWKRYLNGWDNIFSFGKKLIDEKVQELKAQLQETGPDGVRVSGYLHFLLTNELLSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEVTGVVPFGKVPQHKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPNSFQPHRWLRKKEADNPGILHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEIALAPGMGEVKTVSRIVLVPSKKVRLHFLQRQ
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. Negatively regulates male gametophyte formation and double fertilization.
Miscellaneous:
MISCELLANEOUS: Transcripts of KPL and ARI14, encoded by adjacent genes organized in a reverse orientation, have the potential to generate natural cis-antisense siRNAs (cis-nat-siRNAs) pair targeting ARI14 in sperm, thus leading to opposite expression levels during male gametophyte development.
Domain:
Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
Sequence:
MEYDGRRPYSVLTRNEITVKMKKQINEISDIFFISNSDATVLLMYLRWDSLRVSERLGENKEKLLMDSGLKSVMIDPSPDSSSEISLETDVYEFDGDNDLISMPFCSHKFDSKYWREYLEKNFYYVEKIQTTISCPDQDCRSAVGPDTIEKLTVRDQEMYERYIWRSYIEGNKVLMIKQCPARNCDYVIEFHQENDDDDEYSLNVVCICGHIFCWRCRLESHRPVSCNKASDWLCSATMKISDESFSLYPTKTKTVTCPHCLCSLESDTKMPQFLTCVCRLRFCSRCLRSEEAHKIEAVDSGFCIKTEVGILCEDRWNVCQKLLEQAKSDLEAFEETNIKKPSDLLREQDIMIIREGLMLIVQCRRVLKWCCVYDYFHTEYENSKEYLRYLQGNAIATLQSYSNTLQEQKDIVLAAATYEECTFFRHTIPTATSNIGNYFYDFMKTLQDGLVDVKVKSYNGGTGPFWYCDRCTYANTWEDNECEMCYDDSASLVGEISDLFLNKVS
The following text describes a protein:
Function:
Non-catalytic component of the proteasome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTLGPVVTGTSVIAIKYKHGIMIAADRKASYGSYAKFQNVERIFKINNKTVMGFSGELADAQYLHELLTRKNINNLSEKKRKEDMYTPQHYHSYVSRVFYVRKNRIDPLFNNIIIAGINSQKYDNNDDNVLLYTNKNNDDEQNEYKNNEEYKEIHKDDLYIGFVDMHGTNFCDDYITTGYARYFALTLLRDHYKDNMTEEEARILINECLRILYFRDATSSNFIQIVKVTSKGVEYEEPYILPCVLNSADYVYPSTLLPPAGCMW
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM9, it may function as a substrate sensor.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
The following text describes a protein:
Function:
F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'-phosphate (PLP), the anti-tuberculosis drug PA-824 or aflatoxin analogs as substrates.
Sequence:
MARQVFDDKLLAVISGNSIGVLATIKHDGRPQLSNVQYHFDPRKLLIQVSIAEPRAKTRNLRRDPRASILVDADDGWSYAVAEGTAQLTPPAAAPDDDTVEALIALYRNIAGEHSDWDDYRQAMVTDRRVLLTLPISHVYGLPPGMR
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.
Subcellular Localization:
Recycling endosome. Cytoplasm.
Sequence:
MALRGPAGLGPGSRRPLDEAVAGAEGREAPALVAAGGAPEDDEEDDGRGRGLLRWDSFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFRQSSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLPYIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGKTLHLPIMGVVMKVRIPTCHDKPGTTQIVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAPSPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDLKPTGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQKGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKLLQADREHLPVKPDTMEKLRTHIDAIILALPEDLQGILLKTGMT
The following text describes a protein:
Function:
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Sequence:
MSNCDSCASKGTCNSEGSCSKETFKYGNAKNIIGVISGKGGVGKSTITGILATKLREEGYKVGVLDGDITGPSMPRFFGISDKRATIIPTGENEEVKIIPVETKTGIKVMSLNLLTEQEEAPVIWRGPVITGVLTQMYTDTEWGELDYLLIDMPPGTGDIALTVMQSLPVTNMVVVSTPQDMVSMIVKKVVIMIEKMGIEVLGVVENMSYIKCGSCGEKLNVFSKKSAEEQAEYLNIPLIADMPINLDLSEEMEKGEVETFIINNEEYAQLYNNFKNLYK
The following text describes a protein:
Function:
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.
Sequence:
MLKQRTIKSLVKTVGIGLHSGRKVTLSLRPAPADAGIVFTRVDLPEPVEIPVAASAIGDTRLASVLQKNGARVSTVEHLMSACAGLGIDNLYVDVDAEEIPIMDGSAASFVFLLQSAGIEEQSAAKRFIRVKKAVEVREGDKLARLEPFFGFKLAFTIDFRHPAVDKTGQTFSIDFADTSYVREIARARTFGFAHEVEALREMGLARGGSLDNAIVLDEHRMLNNEELRYGDEFVRHKILDAIGDLYVVGHPLIGSYIAHKSGHGLNNQLLRALLADQEAYEFVTFDKVEEAPTAFLPQVQPAFA
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MIKSQVGRRYSKAIFEIAEEKKQVKEIYEMLNSAMVLYRTDKEFKHFILNPLIDNEQKKSVLNEIFGKDNSENLNILLYILDKGRMNCIKYIVAEYLKIYYRKNRILDVKATFTKELTDEQKKKLIDKLSQKTGKEINLEIKIDKDILGGGIIKIGDKIIDGSIRRELDNWRKS
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MGAGKNTAEFFKRRDEWRKHPMLGNQMRHATPGLGIALVAFGVYLVAEQVYNKINSSSHSHHHVCEGWGPLSQDHHQSIVSLVQPE
The following text describes a protein:
Function:
Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Miscellaneous:
MISCELLANEOUS: Present with 3180 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MLGEDEGNTVLEKGNNPSVKQGEVGAVFIVPKILIREHERVILKQILQILDQDELVQPPLDKFPYKKLELPKYIDELKTRDATNTSYKMIQLDAYGEKKVGSNGELFGGRHYLFNTFTFTAHMGVLLVLLQDVIKVLYQSNATHDEDEFIVQHDQILVMETSEEQTKFLAKNGVIPEESKGSFKYITARSAFVEFGASVIAGGQRIVDDYWESLAKKQNLSSHQRVFKLSTNLISKISLLRPSFQNNRISNANEISANTNNTCTISTSKFESQYPIVTEQPSAEIREAYIENFAKGEHISAIVPGQSISGTLELSAQFRVPRYHSKNSFQQALQMKAMDIPIGRHEELLAQYESQAPDGSASISLPNHIPSVNPSNKPIKRMLSSILDINVSSSKNKKSEENEMIKPMNKGQHKNNTSLNINGWKFESLPLKSAENSGKQQYYRGLPLYEKNTLLERLKQLTPNEIKELEHLHDAVFVNTGLQNVRKVRTKKWKKYWQYKAGIPIGLKRSQLDEFKNKYLKDVLAQTSVTTNFNEITNTDETITTKRVPNPNFLGNCNIKDFKPPYIYSHVNKVPQNVAGDKTAVKLDTEVKNTNANPVVATDPVAAKPDNLANFSNEVAMNN