lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Aldose reductase with a broad substrate specificity. Reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde under stress conditions. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation. In pentose-fermenting yeasts, aldose reductase catalyzes the reduction of xylose into xylitol. The purified enzyme catalyzes this reaction, but the inability of S.cerevisiae to grow on xylose as sole carbon source indicates that the physiological function is more likely methylglyoxal reduction (Probable).
Miscellaneous:
MISCELLANEOUS: Present with 12851 molecules/cell in log phase SD medium; MISCELLANEOUS: 'De respuesta a estres' means stress response in Spanish.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSLVTLNNGLKMPLVGLGCWKIDKKVCANQIYEAIKLGYRLFDGACDYGNEKEVGEGIRKAISEGLVSRKDIFVVSKLWNNFHHPDHVKLALKKTLSDMGLDYLDLYYIHFPIAFKYVPFEEKYPPGFYTGADDEKKGHITEAHVPIIDTYRALEECVDEGLIKSIGVSNFQGSLIQDLLRGCRIKPVALQIEHHPYLTQEHLVEFCKLHDIQVVAYSSFGPQSFIEMDLQLAKTTPTLFENDVIKKVSQNHPGSTTSQVLLRWATQRGIAVIPKSSKKERLLGNLEIEKKFTLTEQELKDISALNANIRFNDPWTWLDGKFPTFA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGMAGLISERFIQRRHVGELQELDWESWYEIKELSPKWFVDEEEISQRIVLGRLTSHDLECSSFRGPWKYEGEFERYQGSQERHFRQVTTLQEISAVKRDNEYNNSERSILLKSVLLTQQRVPTVEQVHKFDIYDKMFPQNSVLIEHKRLHAEKESLIGNKCEEFNQNTYLSKDTGIPHGEKSYESNDYSNLFSFHSLLTQHQTTHFGKLPHGHNECGDAFSCYSFFTQPQRIHSGEKPYACNDCGKAFSHDFFLSEHQRSHIGEKPYECKECNKAFRQSAHLAQHQRIHTGEKPFACNECGKAFSRYAFLVEHQRIHTGEKPYECKECNKAFRQSAHLNQHQRIHTGEKPYECSQCGKAFSRRIALTLHQRIHTGEKPFKCNECGKTFGYRSHLNQHQRIHTGEKPYECIKCGKFFRTDSQLNRHHRIHTGERPFECSKCGKAFSDALVLIHHKRSHAGEKPYECSKCGKAFSCGSYLNQHQRIHTGEKPYECNECGKAFHQILSLRLHQRIHAGEKPYNCNECGNNFSCASALRRHQKIHNRETL
The following text describes a protein:
Function:
Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MNLIHKVSTICQCVLVILAKYCMQIIALSLMSGVQWLAWGIYKINKNRVGIIILFLYIMIVTCYVLTNLTPPGSPSETSFDPNSTRQYMTLQNGKSRFCEKCQEYKCDRSHHCSQCNKCILRMDHHCMWFKNCVGFRNHKFFFLECFYLNLYSICVLYSTFVAITKTFTAEGANISAIYLVFWGFLFAFAVGMSIVMTAFTFYHTSLLIHNLSTLESMSSSWSRYTHSTQPFNVGWYENWCQIMGKSPFLWLLPFPNSIGEGVEYPLNANALPYLPQTEEKNDKLYKSSVPASIAGAEGWSSDEEQYAMKNRRWNPHMGQYEWIEDFLV
The following text describes a protein:
Function:
Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus.
Subcellular Localization:
Secreted.
Sequence:
MRTLTLLTALLLLALHTQAKSPQGTAEEAPDQEQLVMEDQDISISFGGDKGTALQDADVKAGVTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
The following text describes a protein:
Function:
Precursors of the cornified envelope of the stratum corneum.
Miscellaneous:
MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
Sequence:
MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSGGCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCHSSGGCC
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKITLKTLKQQTFFVEVDVEQDTVRTLKEKLHAESGLAYPVDRQRLIYLGKIMEDDHLLSQYKLDDKKFIVVMSKKPPADEPAPEQKESGDGKPADKDTAAGRVEGTGEPATSASKPSTGSAVTATASSTATPSPAPAAAAGAPSTASDQKTAAAASPAADSSNPTNPSTDAVPEEMRINIQRLTEMGYPEQSARLALEICANIPDRAVEYLLSEMGGGSDMSFALTAAAQLQQQQQQQQGQGAGIGGAAAAQSGDANPLAFLRDNPVFEDMRRILRDDPSMLPYLMRRMQASNPDLLNIIAEYQDEFLALINEGSNAGGQPAGQPMSRELESIAAAMVNSLTPSDMDAIERLKALGYPEHLVIQAYIACERDEYDAAMFLVTQTLDEEE
The following text describes a protein:
Function:
Specifically hydrolyzes the vinyl ether bond of lysoplasmenylcholine (pLPC) and lysoplasmenylethanolamine (pLPE) to release a fatty aldehyde and glycerophospho-choline or glycerophospho-ethanolamine. The cleavage activity is specific for lysoplasmalogen substrates, and there is no activity on 1-alkenyl-sn-2-acyl-glycerophospho-ethanolamine or 1-alkenyl-sn-2-acyl-glycerophospho-choline (plasmalogen) substrates. Confers a growth advantage for mycobacteria in host macrophages, possibly by cleaving toxic host pLPC into potentially energy-producing products.
Miscellaneous:
MISCELLANEOUS: Overexpression of this gene in M.smegmatis increases its survival within infected human macrophages. Overexpression also protects the M.smegmatis spheroplasts, which are cell wall-deficient mycobacterial forms, from membrane disruption/lysis by pLPC, by rapidly catabolizing it and depleting it from the media.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGSIAGFSSAVLSKLGIPVPYAPRLLAGGWVVAGWAGLAYGVYLTVIALRLPPGSELTGHAMLQPAFKASMAVLLAAAAVAHPIGRERRWLVPALLLSATGDWLLAIPWWTWAFVFGLGAFLLAHLCFIGALLPLARQAAPSRGRVAAVVAMCVASAGLLVWFWPHLGKDNLTIPVTVYIVALSAMVCTALLARLPTIWTAVGAVCFAASDSMIGIGRFILGNEALAVPIWWSYAAAEILITAGFFFGREVPDNAAAPTDS
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Subcellular Localization:
Mitochondrion.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MIRSSIKNKITTTKSLSCISLINRQYGTSTKEVRETFLNYFEKNGHKRLPSGSLLPYNDNSLLFTNAGMVQFKNQFTGNEESKYKKVTTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGGYNHFKRDSIQHAWDLLTKEYGLPKERLAISVLEGDEESAEIWRNQIGLPNDKIMYKGREDNFWSMGDGPGPCGPCSEIFWDHGKEVDGERYLEIWNLVFMQYNKSGKEGDEMPVDKLPIPCVDTGMGLERMASVLQGKFTNYDIDLFQNLINSFKEIVTMDVGRAQFQLQQDPQRVETAYRVIADHLRSISFLISDGVIPFNIGRGYVLRKIIRRALSYGKILGFNGPFLSTLFPLLEREMGDIYPQLIERSNEIRNVILNEEGTFYNAIQRGIPYLEEFVQQNKLNEESLFLLYNTYGLPLEMSQVKAKQNNIEIDMDKVNKLIDETREQSRLTWNTSSSSSDQTTQQTTQLPEKTFLSWKSDNIKPKFIGYNGCVENDNSKVLRSHFDNDSHLVYLSLDETPFYGTSGGQVGDVGELINVSSGKNVYRVINTIKPYEGGLVLVVEWDPSQQLASQVYQDLKQDSLLNCRVDRSIRNQVAVHHSATHLLHAALRNVIGKSVVQAGSLVGSESLRFDFTHGQKLTPNQIEQIEQWVNDAIAKDIALNTDEIPYEQASKNSDTLQLFSEKYSELVRVVSIPGFSKELCGGTHVERSSSIHQFKIISESSVAAGTRRIEAVAGLAATNFFKNHYQLVHQLSNSINSPIVNFQQSFERLVNTNSKQEKEIFDLKLKIAQLSSVNYNGQYKSDNGGEMIPLSLHIIDCEDKKAFTKVTENFAKEFSSSPIQLTISKGGKVLCQLLSSSSSSSSSLSADTVLKQLFKSIGMGKGGGNKLMANASIQPLNNEILNSILNWSNVNNNYNNKKN
The following text describes a protein:
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MEPVMSLALAAHGPPSILEPLFKTVTTSTTTTTTTTTSTTTTTASPAGYSPGYPGTTLLTALFENLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHTRNREGMVRGVYN
The following text describes a protein:
Function:
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADDDDYQDMDNDDFVDDNEMEDVIEEEQQRPDHEEEDDDNNVDENFELFDQGKAVPTSEHVTTPFMTKYERARVLGTRALQIAMGAPVMVELEGETDPLEIARKELKQRRVPIIIRRYLPDGSYEDWPTEQLQLADW
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MMKVDPMTVEDVAANLEPVLSFKEGGVRELIQRLQCSSKRGHGVLPDNTLVLERSCEHPAVVNGVCNDCCQTIEEDGNYGLDFSYLHMGLRLSRGEIDRLCCLETERLFSQKKLHLVLDIDNTLIHSFRSEAFSKLGVPKDDMQEVDGIFVKLRPLVSDFLERASTMFEMHLYTLGSRSYAKKMAKILDPQDKYFDHRIISRDESPGLVKTLDLVLGMESSILILDDNDEVWPNHERNLILMKEFLFTGKKTDENEMNTPLNDILKALSAIHTAFFDDNIQATFRDRDVRELAASVRSTVLKGCNLYVSNVKYSGILRLIAKELGATCSKELNHSVTHLVSCYKGTEDFNRAVREEKYLVRPRWVKDAYFLWKRPAEENFPIKKSSKAILKAIIA
The following text describes a protein:
Function:
Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MYAGRRIRDGETDPAISIPRTRPRTEFLGLGSYCSFFVLELRLPICLETNRVSLWITTRTARPVLQEVCSYAMGIRTAFCKADQDQLASFLAANPGDLNGNAIYKEFAQTHTNHTWQSWRHHYISNSMLINGIIRRIRRLEKEAASKKNQPPSDGHTLPNDNHREPNETHKPQQESAAKKNQPPTDGHTPPDDSDKESRESSTEIVIKRSPMTRKGKEKAAHYLLDTDSDSDCPGTESNPADTPQDFVVHRIPTDHHNHSKNYDHVTDLVSSHQLGKIRSNPSVKLITMSPDEEKKLWQFVSTYPEGDIRLSLTLYENYHLQAPKFSAEQYRTYYLARQNRICRKRPASREPEGMTRPKVNRLNPLPADEARQGLHRTDSLDRSEGRRTLVLNGREDEVPKQSADDVTLDLDTLSVSTGSSDDLELEYILTCPDYHKVARNMNTSEEFLRPLLKLQEDVFRPLDFEILDPVVHQSRPVNQQSTRESLLAGQETQKSLPVLEDPGKQPHSAAKEPAQQASRPAAKEPASRPVVQQKASRPAVQEKESRPAAKEPASRPAPKEPASRPVVQQKASRPVVQEKESCPAAKEPASRPAPKEPASRPVVQQKASRPVVQEKESRTVARAPESRPDVQHKASRSVVQEKQSRPVAQAPESRPVEQQRESRPVKQAGASRPVAKERTSLPVTQAPESRPVDQVRKSGPTVQGGASRPAEQKRASRPAVQEGASRPVVQKTASRPVVQEPKQQKPQPVTQEPKDRPGEQKRGSRQQVVQRRTSRAVNQESRQQIPKPVIQEPEGSAVSTPAESSTLTSGKTSRRSSFNPPQPPKSVQEAVDLLCVFLEDFGELYTPPEAAQLLHQCGDWAVMFEVATLKKLEQELKEASKGPNGQDENEENAVDQEYLLRIQKLVWTPEEDDLVLLHPLPTDPESQVKLRQLLEKKGPQAIENRKAFLRSTM
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MTTAARPTFEPARGGRGKGEGDLSALSKQYSSRDLPGHTKIKYRQPTQDAPEEVRARDFRRELEERERAAVKGRDRGAREHTTSSSSSSSSSSSKRPRLDQIPAANLDADDPLTDDEDDSGSDSDSDDDTAALLAELEKIKRERAEEQERKEREQKAEEERIRMENILSGNPLLNLAGQQQQQQQQQQQTQTKNTFSVKRRWDDDVVFKNCAKGVDESRKEKRFVNDTLRSEFHKKFMEKYVK
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MCWRELGYMCLIALGFTLVVLMLMRFFTAAIVWLVLFTISLTCVGGTSYLWFLWYITRRDLSSLPDSEPKKHLNDLQYWLAAACLATIVTAILLLIILVMRKRIQLTAALFTEAGRALTALPLLFLQPLWTLLFLSTVFAAWIVGMLFIVTSGDLTADKTSGLVYVTQDTLLKVAPWYHLLALYWMTQFIVSCQYMVIAGATATWYFTRDKDLGSPICTSGHYLLRYHLGSVLLGSFLVALVKLLRALLKWIEKQLSGRFSSCKVLLKVCQVCLCCFERFLKFLNRNAFILVAIHGYPFCKAAREAFSLLSKNVLRVAAINCVGDFVIFMAKVGVIAGTTLIGYEILKASSRLRDLLARRKSPAIAGFRVSYLVQLVSMKNEALHYIWLPLVVGGVFAFLISHCFLSVYEMTIDTLFLCFCEDCQMNDGISRPYFMSTNLMAFVKNSRKASKADAKHHKRA
The following text describes a protein:
Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSEEKIEETQQQQQESVPVKELLLKVQLPSFFNVGDDYLTIPSSYEENIADLKQALNIIVLCRNLTNYSILIKGIDIIENFGELITFEQIISHFELDKQEEQEEQGQEREISELKIVIKEKSYNLASIYEQISRFREVIGLHYIDRLSNDIGSCGGVSKFNGIQLDDIKPKEAKKEESTEKEQQEKEELSISKEEVSKISDFAKQFISDSFDGNDFTKLTKFDDINGKVKIPIKSLTISQWSPVPPFQQAKGDLLYLSLQTLEHETFNITCHFSGFFVNKSSTINFNPTIKINEKGKFNKSYLLYDLVCQLSPLFSKTIAENEINLSDSTKYPETYLLPGNSFPAYPWLVNEKDLQNVPDLSRSQLSSLINGVDGADYIKDWNNDIQSIKELPTTTVQERIIREKLIQKSLFEFNKTATETAINIIKGNIPPLNPDESSDKFIYLRNGIFYSSGTSTVNGFENTGGEEASRYVASKDLTGIKLINRHDIRGISSLVTCIVDYMGKRVVCQAPVPGILDTPVITSPTTDAEGKNEAEEPESEPVEKVVYGLSSDGSRILEDKSFEEPLKQIGDFFHLKPHKVQLSSSSSGDDVKTESNLVVSKDTKGLKGTDGRKYVIDLYRTTPRDIEFIEQHFKLDDDHQETSYPHGEALIRHEAVNEWWRRKVAVLFKKETEQLEKEGKLLDKNQDQDQENKPQIAIPTDQVVFNPDAFSSDNENEIEQDREEVREISKFIKEKLIEEFLDEIKDQVIPFDGQQLTDVLHRSGINMRYLGYVAERLVVKKEKHLVDLEELIKENEAKAEKKREEEKEKEEKEATESEDKKEKKEDKEDAEKEEAEAEEEVPTKATYQLTLANYSTLHRIIIQEMISRSVKHILRNLTKSLPSYLISTAIAHFHNCLFGGAINPTPKVDFIDEIYKNFCSKSDLESFIKLTHDDVIKLVSKEVFSRFRYKLSSNWINTIQLPQLFREIAFKYGIQWKSQNYPFTKEEFELQNNQNKETPTQIQIIETKSSKKSKKKTQTQVITEKSIQRSSIFIADDIIGFIPIIKDSSYKSTIVEEIYSNARSHLVQGNKEMGMALFNELLAINESIYGKVNPETAKFYNLVAQVYQELGYDIEAALIGRKAVILCERSCGFDSYDTITAYMNSAYYESSNEQYLNSLKLYKEAMNTWSLVYGKDHPTLINTLTNLSESLLKIKAYDSALELLQEALEITKKLNGEISEITGFIYYRIANIVVTLNKFKESKELFDKAYDIFMKLLGPDDSMTKQVAKYVSSVGLYVEYLKRQQQQQQQETQKKSKTKTKAAPVNNIATTSTSTTKNGKKSKKNNTPPQSNPEIANQSIDEILRFIEGKPSGSKKSNKKK
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MSTVSFASAQLLFIIFWNFIIIPFARLRRRRDFSHSPMAIESFYLKKEHFHGTHFSDEADFPISSLVVLFSTLHFVALLTPFNLSHLSECYVFEDETAKYDITVKGVEISPNPVVRGHPTNMIFNLIIGKPIIAGKMVVDISYFGWHIYSDSHDICVETSCPYLSGDFALPPLRTPLAFFLPGSYHMQITIVDGDDNKLTCFGFDYELVIASLFGDS
The following text describes a protein:
Function:
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPIQIQEINNSEEISDCPLCMEPLEVDDINFFPCVCGYQICRFCWHRIRTDENGLCPACRTSYPEDPAEFKPLTGSDLQKIRHEKRQKEVQRRQKLTDGRRHLANMRVLQKNLVFVIGLSQRLSDQEILKRQEYFGKYGKIVKVVINNNTAYAGTQGPSSSAYVTYSKMEEALRAIQSVNNVYIDGRTLKASLGTTKYCSTYLKNQQCHKTDCMYLHELAEDDASFTKEDMQAGKHQDFEQRLIHQLLQKDEDAGNLGSESISDLDRITLSSESIVTSTRQRRHSGSSSGSHQSSKKGGTESSQSSSSLEDSRSMIHKNDLKKLNSSPPLPLPHTQQSIPPTTIPSLQEPPNHIEDSTYNNEQSNEKFQKDFISLATEKLKLSGNGVQQYSPFQRFHQNNGITPNSNISDPFHSLPTHQPFLHNTTDTTWLSSVQQPQLQDTIPIKSSNDWEAAFGFRNIPVMTSQTPQSTKQEESGDDDLGFDPWLECNKGLADLIAKESATSKSMVGTWPTNNQIQNASQTSYFAHKTDRLINNNPFGLKSNPYSNHEFPTYNNSSNSQSYLDRNLSSSPRKLTEWQSGLRALLPTVNINFAMDNATSTVHQTIRQPHTQTQATMSSQPSMMSSQPSMMSSQSFNDVITTVYDVTTFYDVKW
The following text describes a protein:
Function:
Part of the iron-storage bacterioferritin (BFR) complex which stores about 50% of intracellular iron. Missing most of the residues required for di-iron cluster formation, it probably does not have ferroxidase activity (Probable).
Subcellular Localization:
Cytoplasm.
Sequence:
MEGNLEVRQHLNQALKLQLTAINQYFLHARMCKNWGLNALNQYEYKVSIKAMKQADSLIERVLFLEGLPNLQNLEKLLIGETVPEILGNDLTMNQGIRDGLVNSIAFFETQRDYVSRDVLSEILEETEEQIDWLESQQWLISNSGLENYLQSMMGEE
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular Localization:
Nucleus.
Sequence:
MPKFFCDYCDVYLTHDSMSVRKAHNAGRNHLRNVVEYYQQIGQEKAQSVIDSITSSYAAEGQAVPNPAMAPPGAFPPPFGFPGRPGQLPPPPFGIPPPGGPNGAPPGMPIPPPGGRGLPFPPPFPPAPGGAPGGLPPPPLGNMPPGQGFPPVPPPGGFPPNFQIPPPGAGGFPPVPPPGQPGFSPSPGPGMSGPPAPPGTGSSSLPGPPPGLSEKR
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. May be involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Subcellular Localization:
Mitochondrion. Cytoplasm.
Sequence:
MKASLLVPRRALLFGQLLPPKYSWYSVKRWQSQLTFRNKSKRNTNRIMLSVVSSLNPDSLIAPLLCVSLDNRKYLIGSMGELTQMKFRSQASNYGGKSVSVFLMPPSLQSLNAWGITAGLFGYLQSSGIQNTWGLHAPKPVISIIKKSHHLFSGSPLRLDLNSFSSEDNADATNSFYLDEPEFCTIKGNIYSNWSFLSFNSKEAAGVFNADKALALGVPFGPSNGKLCAGEAVLSKDGTTWIYPHQVVGPPRKRQYFYVLGCSSLSALNQMSKHVDSFSDVYPTCIIHILEKGIWGPEYIKFLSHPKFSRAQHFISCIELASNNPVFQRNKGRNVLPACRDFAAFDIKPSTLDTQTQLPENTYVLKEETSMVLYDEQCKISESPSYSPVKLAKKFSSFNPLPFENEGYTLDVLGTSATCPTWRRSLSSYSVAIDGTVIMLDCGEGAISQFFRQYGTNTEPMLRKLKAIFITHLHSDHYLGLLNVLQAWNKANTNNSMHINIIGPKFLWQWLQRLKSPANLQALLNRIIFIIAKETVTTPLQLTSDLSISSVPSIHINDSYSCIISHTKYGKLVYSGDTRPNEKLVKAGIGASLLLHESTFEDDLKHEAIQRQHSTASEALSVAQSMKAKALILTHFSQRSYDADFLPPDWTIYPKSKTIYANDGLQWQQFQSKQRETI
The following text describes a protein:
Function:
Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MGTASSLVNAGEVIEDTYGGGGGEDCVIPVEVKPKARLLRSSFRRGPRVIGASFKSTASVDLEYAAEYERLKKEYEIFRVSKNNEVASMQKKEIKLDEENKRLRAELQALQKTYQKILREKESAVEAKYQAMERAATFEHDRDKVKRQFKIFRETKEKEIQDLLRAKRDLEAKLQRLQAQGIQVFDPGESDSDDNGTEVTVPSTQCEYWTSGALGSDPSMGSMMQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDAAVASLLQVTPLFSQSLWSNTVRCYLMSTAETQAEVEIFLRDYSPKLQRMCETSGYFFQMVFFPEECESQHFAVRKWEIEKSSIVILFICSSLPSCLQEDCEEAFLKNNEAKPRLIYHSIEDGRSDSDGLKQLLEQDTNKANKTKVVDHCGDPVEGAYKLYCHLEQVIKQDLLGIEISDPDAKDESATMEDDDYGDVLWDVHDEQEQMEAYQQASQSICELGFQKYYDRLNDLVAAPAPIPPLLISGGPGSGKSLLLSKWIQLQQKHSPNTLMLYHFVGRPLSSSSEPSLIIKRLTLKLMQHSWSVSSLSMDPGKFLEEFPHWLEKLSIRYQGNIIIIIDSIDHIQQSEKHMKWLIDPLPVNVRVIVSVNVETCPQAWRLWPTLHLDPLNSKDVKALINMECGGANILLTKEQERKLERHCRSATTCNALYVTLITKLLTWAGSTGKIEDVLQQCLQCQDTVSLYRLVLRSVQEVMPSAKEKEFMREILCFISVSHNGVSECELMELCPGLTWEVLTSLIYHLYTLVLLKYTCGLLQFQHLQAWDAVNLEYMQGGQNIISEYREKIIKHFTTQLSHDRVTWRSADELTWLFQQQGEKQKLHKCLMNLFVSQNLYKRGHFAELLSYWQLVGKDKISMASEYFDALKQYEKNCEGEEKMTSLADLYETLGRFLKDLGLLSQAVTPLQRSLEIRETALDPDHPSVAQSLHQLAGVYMQSKKFGNAEQLYKQALEISENAYGSEHLRVARELDALAVLYQKQNKFEQAEQLRKKSLKIRQKSARRKGSMYGFALLRRRALQLEELTLGKDTSDNARTLNELGVLYYLQNNLETAETFLKRSLEMRERVLGADHPDCAQSINNLAALYNEKKQYDKAEELYERALDIRRRALSPDHPSLAYTVKHLAVLYKRKGKLDKAVPLYELAVDIRQKSFGPKHPSVATALVNLAVLYCQMKKQDDALPLYERAMKIYEDSLGRMHPRVGETLKNLAVLRYEEGDYEKAAELYKRAMEIKETETSVLGAKAPSGHSSSGGDTYSVQNTLPVSVFPE
The following text describes a protein:
Function:
May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding. Unlike Ebola VP24, mVP24 has no measurable impact of host dendritic cell function.
Subcellular Localization:
Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein. Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place.
Sequence:
MAELSTRYNLPANVTENSINLDLNSTARWIKEPSVGGWTVKWGNFVFHIPNTGMTLLHHLKSNFVVPEWQQTRNLFSHLFKNPKSTIIEPFLALRILLGVALKDQELQQSLIPGFRSIVHMLSEWLLLEVTSAIHISPNLLGIYLTSDMFKILMAGVKNFFNKMFTLHVVNDHGKPSSIEIKLTGQQIIITRVNMGFLVEVRRIDIEPCCGETVLSESVVFGLVAEAVLREHSQMEKGQPLNLTQYMNSKIAI
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MCVPGDGAEDADSSSESRSGSEETSVCEKCCAEFFKWADFLQHKKTCTKNPLVLIVHDDEPAPPSEDFPEPSPASSPSDRTESEVAEEVAPPEGSEVKAVAKEVEPMDVEASADQGPPGPSVPPPPPALPPQPEPAAFSMPSTNVTLETLLSTKVAVAQFSQGARAGGTTGAGGSVGAVAIPMILEQLVALQQQQIHQLQLIEQIRSQVALMSRQPGPPLKPSASAPGAASVQLPGLTPHASLQLSAGPATASAGSGSTLSAAFDGPQHLSQPQPASGTSTPCSTSAGPTDSGAHPACSTGPAPGAVAAASSTVGNTVQPQNASTPPALGPGPLLSSASSLPSPLLPQTSSSSVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTSVGLQLPPTVPGTHNYTDSPSITPISRSPQRPSPASSECTSLSPGLNNTESGITVRPESPQPLLGGPPLTKAEPVSLPCTSTRTGDAPVVGGQVSGLPTPAATTVTDSACTSLGSPGLPAVSDQFKAQFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGLQEAMDAELPFDEKNAETLSSFDDDVDENSMEEDSELKDTASDSSKPLLSYSGSCPPSPPSVISSIAALENQMKMIDSVMNCQQLASLKSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAHSNGESFRSKSPGLSHQEDPQEIPLKTERLDSPPPGPGNGGALDLTAGHPGRPLIKEEAPFSLLFLSRERGPSHSTPSLASSPAPTMIKMEVNGHSKAIALGEGPALPAGVQVPTGPQTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGIPQLPVSLGGGAIPPLGAMAGGVDKTRTGSSPPIVSLDKASPETGASRPFTRFIEDNKEIGIN
The following text describes a protein:
Function:
Catalyzes the desaturation of oleic acid (Delta(9)-18:1) to linoleic acid (Delta(9), Delta(12)-18:2).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MAPPNTIDAGLTQRHISTSAAPTSAKPAFERNYQLPEFTIKEIRECIPAHCFERSGLRGLCHVAIDLTWASLLFLAATQIDKFENPLIRYLAWPAYWIMQGIVCTGIWVLAHECGHQSFSTSKTLNNTVGWILHSMLLVPYHSWRISHSKHHKATGHMTKDQVFVPKTRSQVGLPPKENAAAAVQEEDMSVHLDEEAPIVTLFWMVIQFLFGWPAYLIMNASGQDYGRWTSHFHTYSPIFEPRNFFDIIISDLGVLAALGALIYASMQLSLLTVTKYYIVPYLFVNFWLVLITFLQHTDPKLPHYREGAWNFQRGALCTVDRSFGKFLDHMFHGIVHTHVAHHLFSQMPFYHAEEATYHLKKLLGEYYVYDPSPIVVAVWRSFRECRFVEDHGDVVFFKK
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLLRKRCRHGPCRLQFLLLLLMLGCVLLLVAMLHPPPHALHQAVTAQVAEHSPEAGYRLNFGESQEWVLEAEDDGQEYDSLEGLLPFISLQEDQLLVAVASPRVRRNQSQDRRGGSYRLIKQPSRRQDKEAPERDWGAEEEDQEVSEDELTPLSLEEALSARIPLQRALPEVRHPLCLQQHPGDSLPTASVILCFHDEAWSTLLRTVHSILDTAPRAFLKEVILVDDFSQQGQLKSALSEYVARLEGVKLLRSKKRLGAIRARMLGATRATGDVLVFMDSHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFRWEPLPERERKALQSPVSPIRSPVLPGGVVAMDRHYFQNTGAYDPLMSLRGGENLELSLKAWLCGGSVEILPCSRVGHIYRNQDAYAPLDLEATLRNKVRIAETWLGSFKETFYRHSPEAFSLSKAERPDCTERLQLQRSLGCRMFHWFLANIYPELYPSECRPRFSGKLHNTGLGFCADCQAEGDILGCAMMLAPCSDSRQQQDLKHTGRKEIRFGSPRYLCFDVRREQVILQNCTGESPAIHQQHWDFQENGMIVHILSGKCMEAVVQGNNKDLYLRQCDGKASQLWQFDKVNTVDER