lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11.
Subcellular Localization:
Nucleus. Membrane; Single-pass membrane protein.
Domain:
The RING fingers are required for ubiquitin ligase activity; The YDG domain mediates the interaction with histone H3.
Sequence:
MTRVNQLPCDCVSTAEESLTSGTCITPTHVTSLSSPLDRSGDVDPLPVSDESGGSKADESMTDADETKKRKRILSGDCEADENNKSDGEIASLNDGVDAFTAICEDLNCSLCNQLPDRPVTILCGHNFCLKCFDKWIDQGNQICATCRSTIPDKMAANPRVNSSLVSVIRYVKVAKTAGVGTANFFPFTSNQDGPENAFRTKRAKIGEENAARIYVTVPFDHFGPIPAEHDPVRNQGVLVGESWENRVECRQWGVHLPHVSCIAGQEDYGAQSVVISGGYKDDEDHGEWFLYTGRSRGRHFANEDQEFEDLNEALRVSCEMGYPVRVVRSYKDRYSAYAPKEGVRYDGVYRIEKCWRKARFPDSFKVCRYLFVRCDNEPAPWNSDESGDRPRPLPNIPELETASDLFERKESPSWDFDEAEGRWRWMKPPPANHEQRERMKMAMTCLLLFVLIILVGSSSILYQY
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MIGFIGGGNMAEALIRGLVKEGKKNIIVSEPIDERRRYLENCYGVKTTPSNTDVVNLSEIIVLAVKPQNIKEVLEEIKDAVSERHTVVSIAAGIPLEFIQKYLKTDKLIRAMPNLAAIVGEAMTVLALCECLEMKIIAPVRDIFMSVGKVITLPEHYMNLVTALSGSGPGFLCYIVEQLIDVATELGFAEDIAKELIVQTFIGTAKLLDSGLPPDKIRQKVTSPGGTTEAGLKVLSDGALRGIFFKTLQEATKRAQQLSVV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Miscellaneous:
MISCELLANEOUS: Present with 1472 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNGNSTNNEQLQQELATTQDQVASIIESFVELGVSIYDFPGTPEATKGMITNLQRNVDRLYKLNVRSNDPQSSLSKVDIPLEVVQYIEDGRNPDIYTREFVEAIRRSNQYQRGKMHGLKQLRDSLADKIVDEFPELKEPVEDIIKRTSPIDNVSNTH
The following text describes a protein:
Function:
Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.
Subcellular Localization:
Nucleus inner membrane; Single-pass membrane protein. Golgi apparatus. Note=During spermiogenesis, traffics through the Golgi apparatus before reaching the round spermatid inner membrane of the nuclear envelope and later migrates to the coupling apparatus of the sperm during sperm head elongation and differentiation. In mature spermatozoa, is localized to the coupling apparatus of the sperm head and tail in the implementation fossa.
Sequence:
MPRSSRSPGDPGALLEDVAHNPRPRRIAQRGRNTSRMAEDTSPNMNDNILLPVRNNDQALGLTQCMLGCVSWFTCFACSLRTQAQQVLFNTCRCKLLCQKLMEKTGILLLCAFGFWMFSIHLPSKMKVWQDDSINGPLQSLRLYQEKVRHHSGEIQDLRGSMNQLIAKLQEMEAMSDEQKMAQKIMKMIHGDYIEKPDFALKSIGASIDFEHTSVTYNHEKAHSYWNWIQLWNYAQPPDVILEPNVTPGNCWAFEGDRGQVTIQLAQKVYLSNLTLQHIPKTISLSGSLDTAPKDFVIYGMEGSPKEEVFLGAFQFQPENIIQMFPLQNQPARAFSAVKVKISSNWGNPGFTCLYRVRVHGSVAPPREQPHQNPYPKRD
The following text describes a protein:
Function:
MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNDSFSSFKFRRPSSKLHKDPPGYGSRALNSQQSTTSLKRHPSAPVYPRSSAAGSREHLRTRSNAYGSSSSSLDQNSAGASPVLGSSDSGHFHSSHSSRSRPPYSGRFSLNDQSSDELIGAPFDSRGMLSALEEHTAEPDNRSYQPPDPAERYTEKPPNFRSQTTPNPRALRQSASFTTLPPRMEAFPNAAGNDRPTNTKRFSDEATPVRPPGPSRSKKSSFSSFVNSMLGSPRGIKISAPENPVHVTHVGYDNQTGQFTGLPKEWQRLLQESGITQKEQEEHPQTMVDIMRFYEKNARGDDEVWHKFDHAYPQQPTAASPISQPAGSTTYGTQRTSPPTSPRFPQNHEGSFENPRAPPPIPRAAPIAAHAMSPPLGGLVPNRAPPKPPTAAANLVPSRPAPQPPTSSPYSNISTRPSPETQSPQFSTPPIPETEPLPSESQRSRSNSRTNGAQGPWPSVSPSHYQQQQEQAMAVAQQALANKQLERSRSQRQQQQSPRPDQMPIAQPALPQHAPSPEDVALTQASQTARAAPAARPRQRPRQSNAMDVRARLVAICTPGDPTKLYYNLNKIGQGASGGVFTAYEQHTNNCVAIKQMNLDLQPKKDLIINEILVMKDSKHKNIVNFLDSYLHGLDLWVVMEYMEGGSLTDVVTFNIMSEPQIAAVCRETLNGLQHLHSKGVIHRDIKSDNILLSLDGNIKLTDFGFCAQINDSQNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPKIKDEHNLSPVFKDFLHFALRVDPEKRASAHDLLKHPFMNLCAPLNHLSPLVKAARISRAQEKAQKGGV
The following text describes a protein:
Function:
Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAMQDLGFPAYAVTWITNSVIAVGGGGGASNTGVKNQLKVFGYNEDEGNSFFVPMQDIELKDTDDAVMSLDSDGQILIAGINDLSDESSNKHLRIYKKNAKNLFEFEASYQLANFTNSEEYQRLCRYNTQRKLIFIACTNKTFSVIHKYDSGLRFELKDLDVFDISFSPEYCAFASTNAIHIYNWEYKLVQRLELPFEKVSIRGVALMKKNAVLCAFNRVENGTRLGYLARFEMDPKAKVWAFKKSLLLKNSRGITAFCAENVSGMLVIATADCTLRIMTNRLQPISKIPLHKLPITCVSLSPDAENVATVSADGTLAVTYVGKYKVLSSVKITDVGIAPRLLIFAVFVALIAVLYMNILFPGRVLEEFHNFTNMMTHRTVLLLTSWKRLL
The following text describes a protein:
Function:
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Sequence:
MKIPCSMMTQHPDNVETYISIQQEPAEAIKGLTPQDKGGLGIEEVMIDFEGKLTPYHQTSQIALGLISNGIIPGKDVRVTPRIPNANKESVFRQLMSIMSIIETNVQSKELTGTPAISEVVVPMIETGKEISEFQDRVNSVVDMGNKNYKTKLDLNSVRIIPLVEDVPALANIDRILDEHYEIEKSKGHILKDLRIMIARSDTAMSYGLISGVLSVLMAVDGAYKWGEKHGVTISPILGCGSLPFRGHFSEENIDEILATYSGIKTFTFQSALRYDHGEEATKHAVRELKEKIAQSKPRNFSEEDKDLMKEFIGICSKHYLQTFLKVIDTVSFVSDFIPKNRDRLTKAKTGLEYNREVANLDNVADLVKDEVLKQEILSIDNSKEYAVPRAISFTGAMYTLGMPPELMGMGRALNEIKTKYGQEGIDKLLEIYPILRKDLAFAARFANGGVSKKIIDEEARQEYKEDMKYVNEILNLGLDYDFLNENEFYHTLLKTTKPIIMHLMGLEENVMRNSTEELKILNEWIVRMGKVRGSIG
The following text describes a protein:
Function:
A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, rhabdomere membrane; Multi-pass membrane protein. Note=Localized on plasma membrane loops found at the base of the rhabdomere, in close proximity to the calcium stores.
Sequence:
MGSNTESDAEKALGSRLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAVDRSKSTFTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKMLRKTLGRKRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYITAEQRRRDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQEMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASDPIGSKRSSMQRHSQRSLRRKIIEQANEGLQMNQTQLIEFNPNLGDVTRATRVAYVKFMRKKMAADEVSLADDEGAPNGEGEKKPLDASGSKKSITSGGTGGGASMLAAAALRASVKNVDEKSGADGKPGTMGKPTDDKKAGDDKDKQQPPKDSKPSAGGPKPGDQKPTPGAGAPKPQAAGTISKPGESQKKDAPAPPTKPGDTKPAAPKPGESAKPEAAAKKEESSKTEASKPAATNGAAKSAAPSAPSDAKPDSKLKPGAAGAPEATKATNGASKPDEKKSGPEEPKKAAGDSKPGDDAKDKDKKPGDDKDKKPGDDKDKKPADNNDKKPADDKDKKPGDDKDKKPGDDKDKKPSDDKDKKPADDKDKKPAAAPLKPAIKVGQSSAAAGGERGKSTVTGRMISGWL
The following text describes a protein:
Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Forms an essential protein complex with Milt that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs). Also involved in the regulation of mitochondrial dynamics by promoting drp1-mediated mitochondrial fission during high calcium conditions, and negatively regulating fission during normal conditions.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Sequence:
MGQYTASQRKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQSEDALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPIRKPIVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLYMMEEQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKAVIQKNVPDGIYNDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHRGQQFLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRWTLMTLIDVVKTMEYLAYLGFNVHENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGKTGMCRGFLVEDMHKLIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPLQPQEVNCDVACLVYDSSNPRSFEYVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPPHLFSLKTNKKELYTKLATMAAFPHLRQFGLMTEDPKLWLKAGLGVAAATMLGFIVLKTISAAGAHTR
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Sequence:
MRSSGFKRSRSCQRHRSAANTAGETLKGHEARLLRRDALPSLDLPKVRKNKFVEIIPINVGCLGACTYCKTKHARGHLGSYTVDTLVQRLKTVVSEGRDIGANIPALLRALVAALPHRQKYNAPNLHLTASGGNGCHPCVYSFLHVLVQSGRDSVLEGMKREYTFSEFRKIVDTLTRLVPEIHIATDIICGFPGETSEDFDRIMELIREYTFPQVHISQFYPRPGTPAALMKRVPTLEVKKRSRSLTSLFESFTPYAGMEVGLSCTGPSWKQIPLLETMLRKSDASSDCLWEKFVGSGQANLPRWLVHKHSTLLLSRSTRVLYFTNRYTFLIQALDAWWEYGIYSSSKLCPLI
The following text describes a protein:
Function:
Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Binds the metal via the metallophore StP, and transfers the StP-metal complex to the membrane-bound permease. Binds one molecule of StP/metal. Binds StP/Co(2+) and StP/Ni(2+) tighter than StP/Zn(2+). Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Domain:
StP/metal binding triggers a notable interdomain conformational change.
Sequence:
MRKLTKMSAMLLASGLILTGCGGNKGLEEKKENKQLTYTTVKDIGDMNPHVYGGSMSAESMIYEPLVRNTKDGIKPLLAKKWDVSEDGKTYTFHLRDDVKFHDGTPFDADAVKKNIDAVQENKKLHSWLKISTLIDNVKVKDKYTVELNLKEAYQPALAELAMPRPYVFVSPKDFKNGTTKDGVKKFDGTGPFKLGEHKKDESADFNKNDQYWGEKSKLNKVQAKVMPAGETAFLSMKKGETNFAFTDDRGTDSLDKDSLKQLKDTGDYQVKRSQPMNTKMLVVNSGKKDNAVSDKTVRQAIGHMVNRDKIAKEILDGQEKPATQLFAKNVTDINFDMPTRKYDLKKAESLLDEAGWKKGKDSDVRQKDGKNLEMAMYYDKGSSSQKEQAEYLQAEFKKMGIKLNINGETSDKIAERRTSGDYDLMFNQTWGLLYDPQSTIAAFKEKNGYESATSGIENKDKIYNSIDDAFKIQNGKERSDAYKNILKQIDDEGIFIPISHGSMTVVAPKDLEKVSFTQSQYELPFNEMQYK
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MKLLSIASAVCMAASALAADSNIEFILAKFLGLDNMVPKNCHAVPGNVKFLVCDRPEPQAINITALDASAYPLPAGQDVEFEVVGKVNHLVQDGAYLNVSVYSGFREVHRGIHPLCDLMKQHKIGRGCPLKPTKKDIRFKRTVSIPDWIPSSRYFVLATIYNPDKSTVISFSGQYDVKGTPETDARYQKEREEEDERRRLERETKKAKEEEAKKADGGDESVPGGAEAADPDSAAPEEPYTVKVDDDHVEVKGEHAEELLGLAKEVAGLAEELVSEQEHETDTSGTTEAPVRDEL
The following text describes a protein:
Function:
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Sequence:
MDEREALIKAGEIARQVKKEVVDLIKPGAKLYDIAEFVERRIVELGGKPAFPCNLSINEIAAHYTPYKGDGTVLKEGDYLKLDIGVHVDGYIADTAVTFRVGMEEDELMEAAREALENAIATVRAGVMIRDVARAIEETIRGKGFNPIVNLSGHKVERYKLHAGVSVPNVYREADTYVLQEGDVFAIEPFATTGAGQVIEVPPALIFMYLRDRPVRMLQARRLLMHIKKNYKTLPFAYRWLQDFLPEGQLKLALAQLEKAGAIYAYPILREVRGGMVAQFEHTVIVEKEGAYITT
The following text describes a protein:
Function:
Displays esterase activity toward palmitoyl-CoA and pNP-butyrate.
Sequence:
MSTLLYLHGFNSSPRSAKASLLKNWLAEHHPDVEMIIPQLPPYPSDAAELLESIVLEHGGDSLGIVGSSLGGYYATWLSQCFMLPAVVVNPAVRPFELLTDYLGQNENPYTGQQYVLESRHIYDLKVMQIDPLEAPDLIWLLQQTGDEVLDYRQAVAYYASCRQTVIEGGNHAFTGFEDYFNPIVDFLGLHHL
The following text describes a protein:
Function:
May have antimicrobial activity.
Subcellular Localization:
Secreted.
Sequence:
MKLVVAAVLAMAASRWRRLSAHGQVPSSTCADMLPVHGNAMPSTALPYTITVSPTSVNGGDTVRVHISGTEEFRGVYLQRGGAKSSRRVPAARRREQQDRPVRLPAGHNNAFSYISRTPLDTLDIDWKAPYTSDEIVFRATFVKSFSEFWVGVESPKITLGPLRQLDNAVAA
The following text describes a protein:
Function:
Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi), which could be cytotoxic because of its high affinity for calcium ion, thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase, but it contributes only marginally to the total PPPase activity in E.coli, where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase).
Sequence:
MAQEIELKFIVNHSAVEALRDHLNTLGGEHHDPVQLLNIYYETPDNWLRGHDMGLRIRGENGRYEMTMKVAGRVTGGLHQRPEYNVALSEPTLDLAQLPTEVWPNGELPADLASRVQPLFSTDFYREKWLVAVDGSQIEIALDQGEVKAGEFAEPICELELELLSGDTRAVLKLANQLVSQTGLRQGSLSKAARGYHLAQGNPAREIKPTTILHVAAKADVEQGLEAALELALAQWQYHEELWVRGNDAAKEQVLAAISLVRHTLMLFGGIVPRKASTHLRDLLTQCEATIASAVSAVTAVYSTETAMAKLALTEWLVSKAWQPFLDAKAQGKISDSFKRFADIHLSRHAAELKSVFCQPLGDRYRDQLPRLTRDIDSILLLAGYYDPVVAQAWLENWQGLHHAIATGQRIEIEHFRNEANNQEPFWLHSGKR
The following text describes a protein:
Function:
Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior. By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis. Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients. Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes to the amphid sheath glia apical domain in which the AFD microvilli are embedded.
Sequence:
MSNARRRFSTVTQINTEGLQAMGKGGGRMETVGEDGIPADYKGNRKFTTSLGHLALYKEDEGIGTQASFISGYTTPGPKERATSEHVKANLGVMLGVYLPTIQHILGVTMFIRLFWVVGMSGVAWTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAASMYIVGGVEVILMYLWPEMAIGGADALHDTEMFGSLYNNLRLYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIAACIGGGIEKQITMEGMKVCAIDNHLLQSSIVTHPIHKNQTSWFNETVDFCNLCDKSLYLESVFCANVNNDEASAEDDVFCTHYTSKKMTCQLAFPGFNMKTLNDNMWPEYMEKSEVVPGVRGKETAEVVQDESSTFFMLMAIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLRDKFGRSIGNTMVVAALSWPHPAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPILAPFARVTKNNEPFLGLVLTVIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQYSLLKVEDKDPHPKNWRPQVLILLTSQWSKEMIDRRAVSMLNLGAQLKAGRGLAIACAFLKGSVDSQKDKNRARDVKTTLVKDMSSVRLRGFAKTMFYNNHQINGTISGLYQSIGIGGLRPNTILLNWPNEKNPDELVLFAEEIIHGAANDNCLIVTKGITDFPEYSERLTGFIDIWWIVQDGGILMLIAYLLRQHKVWKGCTLRIFAVSEQDSTKSEDMKAGLQKYIYMLRIDAELFIVDLLDMEVSDEVVEKAAEVERKQKEREEMRRSKSGYLNDGFMEDNGKPRQVMMRHSDSARSFSPQPGAHTSINLDETETSFTESLFDDFYRSGTPNEDLEGAMKLNIHKMNTSVRLNRVIRENSPDSQLILLNLPSPPRNRLAFNNSYMTYLDVLTEDLPRVLFIGGSGREVITIDS
The following text describes a protein:
Function:
Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
Subcellular Localization:
Cytoplasm.
Sequence:
MAPIDPHSFTDSAHPLTTHISLTLFFDFPSSTISSATLLSLPTPYTGPLTFDTRSLSVSSVLDPLSLSPLPFSLSPDSPILGQSLTVSLSNQTQILILSKTSPSSSALQWLSPPQTFNKTHPFVYTQCQSIHARSIFPCQDTPAARVKYAAKLNIPRQLSAVMAARHVERRDPLPSEAQGVCEDSVWCGDDRVVEEFVMEQPIPPYLFAFAVGELGFREVGPRTRVYAEAVNEVLDAAAKEFAGTEEMIQVGEKLFGPYDWERFDLLVLPPSFPYGGMENPRMVFLTPTVIKGDASGAQVVAHELAHSWTGNLITNKNNDHFWLNEGFTTYAERRIVEVVQGEDIAALNIGIGWRGLVEEMERFKDTMEFTKLKTNQAGVDPDDVYSQVPYEKGFQFLWRIERQIGRPAFDDFLKKYIATFKFQSIDTDMFLSFLKANIPGIENEIDLKLWTEGTGIPPDAMEPVSNIYSKIVSLANEFKLGRMPREDEVADWKGQEWELYLENLPKSVEASQVTALDARYHLSESKDYEVRVAFLQLAISARCRDYYGKVEKTLKEVGRMKYLRPLYTALVQGAGKEEEKVFARRVFTEACDCYHPIAQGVAEAILAKHA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSSPEEQTSTFRPFTKAERIQQLNEIDKSILQLVQTAGQTLKILTASKEPGEAQSSQEKREAFENASNAYLKTLQSVDVRLRRQILGLEEADIIPAEKVNSKNKGKPAAEPMERRPAVPGNMAGNKADDTIIEGGLGNLDIGFLNSRSGRVGRDMEAELWAKSRRFLEDLDNGNYNSQPLSQRKDEIKQ
The following text describes a protein:
Function:
RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, P-body.
Sequence:
MEVVEGRRKTCLDVVDSPSSRQKQTIAVSLVDGKNYPTRFLNSRTIDKLKQELNTSNLSTGEMSTNETLKNAQEVAGKLLSEENEDSISEHFDEYLGADKPGISFLTRLKTLESWFQSLSLQDRLTTLRTLLHHLPSQEISTLLSSSLTSSPSNSGLSLDKSLPSSPKGDSPSLSSSLPSLTTKSNLSGNLNMVTPASTQGPAFSSKHGFSNALSTASPIPVRTSSVSSTYLTQDREASSKNCLSKALAFSSIEPPASSASTSPRNTPTPSNNGTSINANVTSSLTSNSTGKTSKTTDLLIAASKKSLPSNSTPSKPNTSFFETPHNNIWDSRDRGAFSAPPAPFFPLGFSPHLNDESSRSRWSNISYSPPPPPPPPELLNHSPKSRPLGDKPYLFYRNNQIGPRTRTEGRSSITEGKPFLSSSLRFEHVPSANDLNSVVNARVEKSTGQPSTPLNRQHYFNELPHSTTPVTLPSLIHGSEIDRRRSGFCLNNFNSTPPFQPYHYEIGSGLPQQMHATNTILTNPIDPNSNISTPVGMHLCTLPYTYQPFSSVEKIETPPNNSKNQTYRRSSRGSNKTRKSISHSKNTDKHVGNELPQDIPSWLRSLRLHKYTNNLKDTDWDALVSLSDLDLQNRGIMALGARRKLLKSFQEVAPLVSSKKMNENLKAAKNQSSESLTSFKGHTDSEDLPSGSMSNEISSNSTKQDVSSSSMD
The following text describes a protein:
Function:
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane raft. Membrane; Single-pass type I membrane protein.
Sequence:
MERYQLSVLCWWTFLISTVVDWRGVDGNNPFYRPYRIPQLCKFCDVLESNCNGKDTCESNCSITSICESPDEICVAIWRQSDDNNTIETLCHNPTVPLYGIMVENNNNTKCEMKKRISNSGPFHICSCNEVECNDMLLFKLPTNNQVVLVILVSLLPLLVLAVLVIASFYWYRLYRRRKLDEWETKKPSKHKGPKGALDCSDACAIMMDDDRSDSSSTHANNINHNMDPLPIELDLQVGKGRFAEVYKAKLRQSPSEQFETVAVKIFPYEEYASWKNEKDIFQDIDLKHENILHFLTAEERKVEKQYWLITAFHPRGNLQEYLMRHLLSWEDLRLLGSSLASGVAHLHSDHTPCGRPKVPIVHRDLKSSNILVKNDLTCCLCDFGLGLRLDNSLSVDELANSGQVGTARYMAPEVLESRINLENIESFKQTDVYSMALVLWEITSRCNAIGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSSWMKHQGVAAVCATINECWDHDPEARLTAQCVAERFNEMDDDLDKLSTCSSSEEKIPEDCAVSVSDDK
The following text describes a protein:
Function:
Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity).
Sequence:
MITDVWKYRGKSTGELRSSVCYAIKTGVFDYAKQFPSSRNLEKFGEARQDLTIKELAEKFLALKETEVAKTSLNTYRAVIKNILSIIGEKNLASSINKEKLLEVRKELLTGYQIPKSNYIVTQPGRSAVTVNNYMTNLNAVFQFGVDNGYLADNPFKGISPLKESRTIPDPLSREEFIRLIDACRNQQAKNLWCVSVYTGVRPGELCALGWEDIDLKNGTMMIRRNLAKDRFTVPKTQAGTNRVIHLIKPAIDALRSQMTLTRLSKEHIIDVHFREYGRTEKQKCTFVFQPEVSARVKNYGDHFTVDSIRQMWDAAIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIANQMGHADAQMVFQVYGKWMSENNNAQVALLNTQLSEFAPTMPHNEAMKN
The following text describes a protein:
Function:
Required for the formation of the mature spore wall, where it is needed to ensure correct localization of 1,3-beta-glucan.
Subcellular Localization:
Cytoplasm. Secreted, cell wall. Spore wall. Note=And spore wall during sporulation.
Sequence:
MRLSSRFYLFTSFTAWSVVIAGATPAVCGAPEYIIETQNDLDVLSNCQVVNGSIIMNTSSATSLNFNRIETITGDLIIRNNNYLASVALTSISSVGGELRFEKLTRLASVYAPQLANVGQLTMRILPNLQGIRFDKGIKKAHKLTIEDTQLSTLAGISLNTTDTMVIVNNNYLREVDMPYLESVESKFYVSYNAREISVTLPRLKTVGDMTIQRVAHLQLSNLEEVKGFLGFLNSTLQDISCPNITRIGQSLFFIGNQELTSLNFKQLESIGGTFMIANSAALAQIKGYDKLKTVAGSIDFTGNFSSVELPKLRDVKGGLNIQTTSSDFTCPFRQSDGIIKGKSFVCRGSVDNPRQSKESSFDDDDFDELLGNGTIKGSKNSTSPVKQSGAAKVDSRPFRLVTFFLVLVSGFAHLL
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MASDDECYYEEEEDDEGLDADEDYVGLHEEAAPSPQHCGDHWEQDLSMASNLVNIERHNARALLIHHRWKMDRIHDFLVRKGRDRMLKEAGIVTESYITCDVCFEDIDSCGVSNMDCGHRFCDDCWAGHLLASLDMGKKQIRCMALKCPAICGDGMVRRLLGQKYPDAVLRFERFIVESYLENNETVKWCPSAPHCGRAIRVEASERYCEVECPCGVGFCFNCAAPAHSPCPCPMWDKWDAKFRGDSENLKWIAVHTKSCPGCQKPIEQNGGCNHVRCRCGQHLCYACGAVLDSTHNCNRYKEGNANANVNSIRREMLRYTHYCDRYNVHLSSYKMEQEKLWPAIDKRIRQLESACVIRPIIRDSSWLTRAHRSLLRSGQVLARLYAFPYYMFGGGEVRTYPSEKANLAMAQVLFENQQEQLERNVERLSKVLAAEMPVLAEEELLRTMQETANLAKIVETHCGEIYKCIQDKLLPLLVDPMSIATYRPDGPEKAKELPA
The following text describes a protein:
Function:
Required for synthesis of full-length mannan chains; The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.
Miscellaneous:
MISCELLANEOUS: Present with 3480 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein.
Sequence:
MAIKPRTKGKTYSSRSVGSQWFNRLGFKQNKYGTCKFLSIITAFVFILYFFSNRFYPISRSAGASYSPSHGLYINEIPASSRLIYPHVEHVPVLKQMTVRGLYITRLEVDGSKRLILKPEENALTDEEKKKTTDQILLVKHSFLDHGKLVYRKSNDAPEVVVVTLIDFENYELETIIQIVQNRVDYAQKHQYGVYIRWIQEFLPVLENQNLAESYEFIKPLVIRAAMHAFPTAKYIHFVDQDALLMNLDLSLQKYLLDPKIMDLALLKNVPVVANSNIKTYNHFEYSSAKIIIPHDADGNIDASSFVIANDFYGKALIDYLNDPLLRNFPWDNTGDKLSAAIGHILQWHPTLLGKTAIVIPKVLASQYDASLDQEGESGNGASNGDVYHYNEGDLAASFKGCRSRGTCASEIGHMYQKIKKS