lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MSISLLCCAAFPLLWAGPVNAGVTQTPKFRILKIGQSMTLQCAQDMNHNYMYWYRQDPGMGLKLIYYSVGAGITDKGEVPNGYNVSRSTTEDFPLRLELAAPSQTSVYFCASSY
The following text describes a protein:
Function:
Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol.
Sequence:
MQSPLDEVVRRQKAGRPQGITSVCSAHPLVIEAAVLQARETGGPVLVEATSNQVDQYGGYTGLRPADFRDLVYGIATEHGLPLDRVVLGGDHLGPNRWQSLTPDEAMGQADALVAAYAEAGFTKIHLDCSFACAGDPAPLTDDVVAERAARLIRVAEDTVGPERAERIRYVIGTEVPTPGGAHETLGALLPTTPEAARTTLEQHRKAFARHGVEGAWPRVMALVVQPAVEFDHLRVVDYRREATEELRKVLDDEPTMVYEAHSTDYQTAEALTALVEDHWAVLKVGPGLTFALREALFALAAIEDELVPAGERSRLPEVVERRMLAEPAQWEGYYPGGDAEQRLARRYSYSDRMRYYWTDPEIEAAQARLLANLTAAAVPLPLLSAHLPLQYARVRRGELAPRPRELAVDHVRDVLRDYDRAADQNRNQNQREFV
The following text describes a protein:
Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSLQALLRQPAPASAPATVASCLEAHVPVYAFPATGVWVDSALGMVAPVAKLARIDSMPAVPDYFAEARCDSPPPTGLALPEYGLGVPGSDSPCCAGTGSSDCASPAVEDVPDADLHGYSFNDLPLAISGIDVGSGSGASSPLASSAGVVPSMDEGADVDVDVDAVVTLAASSPHKAAGLHPRHPGHHQAPRRHASDVEFVRMARRGGAGAAAAATAVSAAKAAADIGGAEVPGRSLLEGVVMALWEDRADRGMFRYDVSQCETRVLPGPAGFVAQLNEGRATKKRPTEFSADRVMQPFDPARFHFNKAAMGEVLFAFQADATASATSATATAAPRLLLPSAPMAKSALLASNPVSGSPNLVLINVSPIDHCHVLLVPRVLDCLPQALTPDTALLALQFAAELGGSSSSRSGSGAFRVGYNSLGAFATINHLHFHAYHLPAALPCERAPTCPLPGALARPLAASQQPRKRGAEEVAGAGSAGSVRVSRLVGYPVRSFVVEAEAGAALEAVAAVVARAADAMQAANQPFNIIASDGGRRVFLFPQCYAERQAAGEVPEELLDTGVNPASFEIAGHLVLKRAEDFALADEAWAARLLSGVSLSEERFMEVANMCFGSSA
The following text describes a protein:
Function:
Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid.
Miscellaneous:
MISCELLANEOUS: The nature of the anionic polymer present in the cell wall of B.subtilis depends on phosphate availability. Under phosphate-replete growth conditions teichoic acids are present, whereas under phosphate-depleted conditions, at least part of the wall teichoic acid is replaced with teichuronic acid, a non-phosphate containing anionic polymer. The synthesis of teichuronic acid is accompanied by degradation of teichoic acid and reutilization of liberated phosphate for other cellular processes such as nucleic acid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGVIPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKAAAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAIHDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSAGYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALDIIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKEMELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLEELAKDLGSVNL
The following text describes a protein:
Function:
Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MHHREIPLTLLILMFISTSEEICISRHHITAVEGEPFYLKCCPSSSEHKNKTTTIKWYKNESHGPTELRSGGSPRIILHDYVLEFWPVEMDDSGSYSCRMGNDTQAWKLNVIRRSKNSCFTEKQVISKVVEVKKTLQVPCENNYFQNLANRTSLYKDCEKIDFNFNLNLKKIAEFKDGGYYTCVFFLHHAGKLFNVTKTFNITIIGDHSSIIPALLGPKLTQVKVELGKDTQLNCSALLNEKDVVYWNTWRENGSDPNVHEEEGTRIRTPDGKWLASKTLRIENVNEKNLNFLYNCTVASKGGTDTKSFILLRKEDMADIPGHVFTRGMIVAALISVSIVCLVIMGVIYRVDLALFYRHFTGRDETLTAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVGDFTFLPQSLKLLKSHRVLKWKAEKSLSYNSRFWKNLRYLMPAKTVKPCGDESEVLPVLSQA
The following text describes a protein:
Function:
Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). Regulates endothelial cell proliferation, migration and tube-like structures formation (By similarity). Modulates endothelial cell differentiation through NOS3 (By similarity). May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation. During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3. During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase. Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (By similarity). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif.
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm.
Domain:
The bHLH domain mediates transcriptional repression by inhibiting TCF3 transcriptional activity through heterodimerization.
Sequence:
MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPVRRANGYKTFRLDLEAPELGATVSTTAATNGLRDRTQPFPIATPVPASVAPAVPPGGGTDTAREFRGIRAPEVSDARKRGFALGTVGPGLPTPPPPPASQSLAPGDPEAHSFREQALRPRILLCAPPARPTQSAPLAPPAAPQESPVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASTEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MTSAEATPVLQLSGIGKEFGAIRALHDVDMQVFPGEVVGLMGDNGAGKSTLVKIIAGNFRPSHGEIRFAGSAVHFNRPVDARTVGIEVVYQDLALADNLTAAANVFLGRELKRKFGPFALLDHKAMAARALELFGELRSETRPDDLVKQMSGGQRQAVAIARTRLSNARLVMMDEPTAAISVRQVEQVLSLIHRLKEQGVAVMLISHRMPDVFAVCDRVIVMRRGEKRADKAIQATSPEEVTALITGAKEAA
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MKHICNCPKYCGLNCKYAKPELTNSPLKRGLSPNGKAHSCIHFPLSHTLRRRASEKNRKKMMTATKGWAFALMVIFSVLLSWSIPRGESERAFISFSSHEPLVKAVSLASADGGQDFFMEMTDSVAMNIEYDFYRDTCPEAETIVSSTMAQIYSQHKNVSAQLLRLFFHDCFIQGCDASVLLDDSNGNKNHSIEKQAVPNKTLKGFDKIYQIKEVLENVCPGVVSCADILALATRDGVVLAGGPFYPLFTGRRDSARSYYDEATAEIPKPDDNITQTLHLFSLRGFTDRETVSLLGGHNIGKIGCEFIQSRLHNFKGTGKTDPTVSPSFLNEMRVFCEDNGNEKSSQGSPMAATMASPMAFPTAGPMASSPMASRGMSEKPAPRGMPYFQQLSSSVSSGAGFDTHYYQSLLRGRGLLFADQQLMANERTARLVRAYASDDGSTFRMDFARAMMKMSNLNPLTGSQGQVRLECTLAS
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDSQRNILLIALALVSFLLFQQWQVAKNPAPQATQQAQSTGAAPAPSFSDELDPTPAQNVAAKAKTITVSTDVLTLSIDTLGGDVVSAKLNQYSEELNSPESFVLLQNTQGHQFIAQSGLVGPQGIDVTSNNRPAYQVSADSFTLAEGQDELRIPMTYQANGIDYTKTFILKRGSYAVDVVFDVANNSGSEATLGMYAHLRQNLLDSGGNLAMPTYRGGAYSTSDVRYKKYSFDDMKDRNLSAPNDVTVNWVAMIQHYFASAWIPRDEPQAQLYSRVINNLGDMGIRTPNKTIANGDKAEFEATLWVGPKLQDQMAATAPNLDLVVDYGWLWFIAKPLHWLLSVIQTFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPILLQMPIFIALYWALMESVELRHSPFFGWIHDLSAQDPYYILPLLMGASMFVIQKMSPTTITDPMQQKIMTFMPVMFTFFFLWFPSGLVLYWLVSNIVTLIQQTLIYKALEKKGLHSK
The following text describes a protein:
Function:
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or RUB1. Preferentially cleaves ubiquitin from peptides and small adducts.
Miscellaneous:
MISCELLANEOUS: Can hydrolyze human UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. It can do so despite of the fact that the C-terminal 'Gly-76' of ubiquitin has been substituted for a tyrosine in UBB(+1).
Sequence:
MSGENRAVVPIESNPEVFTNFAHKLGLKNEWAYFDIYSLTEPELLAFLPRPVKAIVLLFPINEDRKSSTSQQITSSYDVIWFKQSVKNACGLYAILHSLSNNQSLLEPGSDLDNFLKSQSDTSSSKNRFDDVTTDQFVLNVIKENVQTFSTGQSEAPEATADTNLHYITYVEENGGIFELDGRNLSGPLYLGKSDPTATDLIEQELVRVRVASYMENANEEDVLNFAMLGLGPNWE
The following text describes a protein:
Function:
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Domain:
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases, PTPN11 and INPP5D.
Sequence:
MADSSIYSTLELPEAPQVQDESRWKLKAVLHRPHLSRFAMVALGLLTVILMSLLMYQRILCCGSKDSTCSHCPSCPILWTRNGSHCYYFSMEKKDWNSSLKFCADKGSHLLTFPDNQGVKLFGEYLGQDFYWIGLRNIDGWRWEGGPALSLRILTNSLIQRCGAIHRNGLQASSCEVALQWICKKVLY
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP2 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP1 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP2 binds through its N-terminus to the SRP1 nuclear localization signal (NLS) binding site, thus accelerating the release of the NLS-cargo. SRP1 in turn is released from NUP2 by binding of the GSP1-GTP associated export factor CSE1. NUP2 may also have a chromatin boundary/insulator activity through indirect interaction with genomic DNA via CSE1 and blocking of heterochromatin spreading.
Miscellaneous:
MISCELLANEOUS: Present with 2960 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: FXFG repeats are especially abundant in NUPs on the nucleoplasmic side (in a highly charged environment and enriched in Ser and Thr).
Sequence:
MAKRVADAQIQRETYDSNESDDDVTPSTKVASSAVMNRRKIAMPKRRMAFKPFGSAKSDETKQASSFSFLNRADGTGEAQVDNSPTTESNSRLKALNLQFKAKVDDLVLGKPLADLRPLFTRYELYIKNILEAPVKSIENPTQTKGNDAKPAKVEDVQKSSDSSSEDEVKVEGPKFTIDAKPPISDSVFSFGPKKENRKKDESDSENDIEIKGPEFKFSGTVSSDVFKLNPSTDKNEKKTETNAKPFSFSSATSTTEQTKSKNPLSLTEATKTNVDNNSKAEASFTFGTKHAADSQNNKPSFVFGQAAAKPSLEKSSFTFGSTTIEKKNDENSTSNSKPEKSSDSNDSNPSFSFSIPSKNTPDASKPSFSFGVPNSSKNETSKPVFSFGAATPSAKEASQEDDNNNVEKPSSKPAFNLISNAGTEKEKESKKDSKPAFSFGISNGSESKDSDKPSLPSAVDGENDKKEATKPAFSFGINTNTTKTADTKAPTFTFGSSALADNKEDVKKPFSFGTSQPNNTPSFSFGKTTANLPANSSTSPAPSIPSTGFKFSLPFEQKGSQTTTNDSKEESTTEATGNESQDATKVDATPEESKPINLQNGEEDEVALFSQKAKLMTFNAETKSYDSRGVGEMKLLKKKDDPSKVRLLCRSDGMGNVLLNATVVDSFKYEPLAPGNDNLIKAPTVAADGKLVTYIVKFKQKEEGRSFTKAIEDAKKEMK
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Subcellular Localization:
Nucleus.
Sequence:
MSIKLTENAIPAITSGDVDAKPLVQVISITLLVDSDDSLLRKYYLKLSDGVYSHSATIAAQLNDGVGTGRVKEGSIVKLLDYVCPTIVIRKIIIVHKMETIVLDSQIIGNPKSFVDPELPMVENEEPIPIAALHPYKGKWAIKARVTSKGHLRHYNSPEGYLKAFSFDVLDSDGGEVQVTCLNDVIDSFYEVIEVGKVYLISKAGLIPVGSKDLKHLKIDWEIMLNSNSTVELCPDEDGSIPMHKFSFRSISDIENIESNTILDVIGVVTSVNSSVLMSRENALEMRKRILNLKDNSGRSVELTLWGELCNREGQELKDIVDAGGFPVLAVKAGKVIEFRGKSINAIPISRLFVNPDFPEAQSLRLWFDQDGKDSASSSISKDISYGGPKNELRKTVSQIKDEGLGCTDKPDWITTRATISFMKTDVFCYTACPVMIGDRRCNKKVTRSGERCSKKVTKTVNTRWKCDTCNQEFDVCEYRYILQAQIVDHTGLTCVTAFNEAGEDIMGYSAKDLYVLKYEQEDDERFRDIIKSILFNQFVFRLKIQKELCGEEQKVKIIVVKADKVNYSAESKYMLDLISKFEILLLICFYDVSKWKLLLRWKVIVLRDNQFEGEIPPQLFNLSSLFHFDLANSYLLANNLFGEILLEIFLLIQIQAFNLSHNNLSRTILEMIKDMKNLESFDLSNNMFSGEISQSMTHLQSFDASSYIGNRELCRAPLKKCITKDENSKRTNPSMENEDGDSIRELLYLGIGVGFAINWYTIFLKKEDGGLEVRRIREFNMSLLQMVLEVNGGKKLLVYKVLVVRYGEEGGTIGNGGTLASVW
The following text describes a protein:
Function:
May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrates in spermatid centrioles during flagellogenesis.
Sequence:
MASVVVKTIWQSKEIHEAGDTPTGVESCSQLVPEAPRRVTSRAKGIPKKKKAVSFHGVEPQMSHQPMHWCLNLKRSSACTNVSLLNLAAMEPTDSTGTDSTVEDLSGQLTLAGPPASPTLPWDPDDADITEILSGVNSGLVRAKDSITSLKEKTNRVNQHVQSLQSECSVLSENLERRRQEAEELEGYCIQLKENCWKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQEPEEKQEPEEKQEPEEKQKPEAGLSWNSLGPAATSQGCPGPPGSPDKPSRPHGLVPAGWGMGPRAGEGPYVSEQELQKLFTGIEELRREVSSLTARWHQEEGAVQEALRLLGGLGGRVDGFLGQWERAQREQAQTARDLQELRGRADELCTMVERSAVSVASLRSELEGLGPLKPILEEFGRQFQNSRRGPDLSMNLDRSHQGNCARCASQGSQLSTESLQQLLDRALTSLVDEVKQRGLTPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKMATLDHLHLKMCSLHDHLSNLPLEGSTGTMGGGSSAGTPPKQGGSAPEQ
The following text describes a protein:
Function:
Gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Required for primary piRNA biogenesis in both germline and somatic gonadal tissues.
Miscellaneous:
MISCELLANEOUS: 'Vreteno' means 'woolspinning spindle' in Bulgarian, referring to its eggshell phenotype.
Subcellular Localization:
Cytoplasm. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Note=Component of the perinuclear meiotic nuage (also known as germline granule or P granule), a germline-specific membraneless ribonucleoprotein biocondensate involved in post-transcriptional regulation of transposons and mRNAs. Localizes to Yb bodies in follicle cells.
Sequence:
MESESSQDDWSAFDPMSREYYDQVGNRYTNESGQKLIMEAPLPPKDEKEQRATRQAKYPYLVVPKSSPYVTEKMLINFFGRALIKEMEFRRLSRVYFVYFENIASLETAQQRVQRYPNLIKCITGRPQKEREITSDPVTSTEPMPTPGPAISATERTPVNHNREVPISTGGQNHPEFFRPPLVTKDDYKRGSLLATNDPIQRYLNVKYEFALERHDIYKLKDETRIPQVVLHFRSGRTIPLSTVAVTEEDKTKSLLEDGVSKCVVCQNWTDTFCKLCKMPFCNASCFADVAEQHKQACGKGEILNLDEKVGRKYPKPGLPPSGSKVRITAFEQTNVVYVRSADIQIDIAYYTVLTEVMMLGKDASKLQSTPVCGQIVLYKFEGHMSRAMVLNVDNIKEIYVVFIDFGSVEVTQLERLYECSSYLAGLTCYPVAVKLRGVPRRFVGPNIREVMYELDQSLVFNIKYSSREYDTSKGMQVVVMTEIDINRSLNRLFKTILTPVEPSVSDLGYKEDCLPYIPLHCGKNINVVVMDNTFIQCGFIYCTSIDLAYEVTKMQRDIQEYGEKIAKCATYAPPINELCIAKYEGKWRRGLSVELVGDGYPSILFIDYGNIVPTHVTDIRPYPPQFIFPIMTTQLDLIGVPEKPTDEQIKWLDKNYPIGSVITCSEITFDEETNSYSTRIEKLQEFLSLD
The following text describes a protein:
Function:
Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus envelope.
Sequence:
MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANSSVMRFLRDLIHTGVANDHEEDFEVRKELIGQVMDQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MLLFCPSCSNILTVSVTPHSSTPTPTSTQDLSGANRLECLTCPYQYILTRSIYDRKTFVREEKEDVFGGKDAWANADTYPKQCANSECNGMVAAARFVQIRSADEPMTGFYRCMTCANQWREN
The following text describes a protein:
Function:
Catalyzes the epimerization of D-Ala-D-Ala to D-Ala-L-Ala. Has broad substrate specificity and catalyzes the epimerization of a variety of dipeptides containing an N-terminal Ala followed by a hydrophobic or polar residue, such as Val, Ser and Met (in vitro).
Miscellaneous:
MISCELLANEOUS: Part of a large, functionally divergent protein family. Protein modeling and substrate docking were used to predict the substrate specificity, prior to biochemical analysis.
Sequence:
MIITQVELYKSPVKLKEPFKISLGILTHANNVIVRIHTASGHIGYGECSPFMTIHGESMDTAFIVGQYLAKGLIGTSCLDIVSNSLLMDAIIYGNSCIKSAFNIALYDLAAQHAGLPLYAFLGGKKDKIIQTDYTVSIDEPHKMAADAVQIKKNGFEIIKVKVGGSKELDVERIRMIREAAGDSITLRIDANQGWSVETAIETLTLLEPYNIQHCEEPVSRNLYTALPKIRQACRIPIMADESCCNSFDAERLIQIQACDSFNLKLSKSAGITNALNIIRLAEQAHMPVQVGGFLESRLGFTAAAHVALVSKTICYYDFDTPLMFEADPVRGGIVYQQRGIIEVPETAGLGAGYQKDYLSGLEKICIN
The following text describes a protein:
Function:
Together with MWL2, contributes to secondary cell wall biology, specifically lignin biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFIFLFGLAAFFLCLSAEFQKAKALLRAQVFLKGKDLKWDGESCYLPENRAFGLGIAALVCVSVAQIVGNVVICRGFTKTDKTRTTIFCIILLLFSWVNFAVAVTLISVGASMNREQIYGKGWLNRECYLVKDGVFAASGFLSVTTMAAILGAFAFKVKPSLQVENHDKRHTQNV
The following text describes a protein:
Function:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein.
Sequence:
MAAPEPLRPRLCLLVRGEHGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDKETDEELRRRQLTCTEEMAQRGLPPALDPWEPKADWAPAGSLSGEAGQKDVNGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAAHSGLRAQDRLIEVNGQNVEGLRHAEVVACIKAREDEARLLVVDPETDAYFKRLRVTPTQEHMEGPLPSPVTNGTSSAQLNGGSVCSSRSDLPGLDKDTEDSSTWKRDPFQESGLHLSPTAAEAKEKARATRVNKRAPQMDWNRKREIFSNF
The following text describes a protein:
Function:
Together with skp1, essential for septum processing and cell separation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Constantly expressed throughout the cell cycle. Expressed in nucleus except the nucleolus and is localized at cell tips on both sides of the septum in septated cells.
Sequence:
MKPSEAREHAIRKIKEYLERRHKQQFKALFGCLTINIYLKIFTLISTPDLCNCRLVCRKFQQLCDYNSIYVKKLLLMNAWDVTLSRKLYYESQDGMSQANMSSNTSKGFHLQSSDKKYADSDRPKLSSSSLLSLPDQKIPFPVDYSTVQGKQVVLTVLDCVSQRVEFARLDYIKVWRALAPIYRNLAYASNTIDPIAFSAFRTPEEQSKVLKYLIRFGNSYPYGTYRQAMQNAILDMASLFEQACLDEFELGLHSRNLDLLRKFSHVLHDFSGPNAYVSMYLAKQTDFVRSFFHFDPYSLFISNNLEEIHINWNILESVVNDTIKLLESESKFSEATLPEPELVQVPYAKDILGNSLKDYVISICEHIGEEETELFLVFISGFYGLCKKFFSIPNGPALVDTIFQPQIDIFISQELHYFKTVGWSLVDQWDQKLEEKEDATECFFYKNVSQNTAKNNFLETFKNVMLLPVSLFTIPSENNSASNLAEKAIEQKEEEDPELSKLDAARFVPANIYVSKDRLKHLPTTELAAQAAVLDSKLEGISTMFSLELALKIVHLCKVSLARAKVFMGTSVPQDDDIKGLSKDLFVQLLRELGQGHLKHGFDRAIEHLSSFDPRRDFSSNTVEPVVKFLELINVGDMIQQMMDSFFNEEMSPICVKDDMFDPAIAEKKKFEQLLDERAAFGLHKGINVLIEHADFLLETKTPMNLFSDQTIGSITNTIEPTAAAKNVVQFLGFHMRILVGRADHEILDVFYKEVGMRLFDSLTRYIKSHKFSVDGGLKLLSDCNLYYEFIHSLHQSSLLPYFKTLKEIAHLFIIDGKNAEEIGKLATDTSRFSSAFHTEEVYEILHSRIDWLNIKYEVDKVIHGLACCIM