lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Subcellular Localization:
Secreted.
Sequence:
HQIMETLPRLLIFPHTASAKHAGRGELLDDYESTKGAWIQSQLSKQYKLTGEEECAKKCDEETSFQCRSFQFNSEDQQCETMAENHKTSTVTKKRDVILFEKKIYLSECKIGNGESYRGTMAKTRTGVTCQKWSADSPHMPKYSPKLYPSKGLEENYCRNPDQDPQGPWCYTTDPEKRYEYCDIPECEEECMHCSGENYQGKISTTKSGYTCQAWSSQMPHSHGYIPYKFPSKNLRKNYCRNPDGEPRPWCFTTSENKRWDFCDIPRCTTPPPQPGPTYQCLVGKGDSYRGKIAVTASGKTCQRWSEQTPHRHSRTPENFPCKGLEENYCRNPDGESAPWCYTTDSDVRMEHCNVPLCGAQVPTDQPEVLPEETPVVEECFQGEGKNYRGVSSTTVSGRKCQPWWSMRPHYHSKTPLQYPDKYCIEVDSWGGPTAKYSLGGRFGRTPSRRACVPEGQSDRSSTSITVNKTRDAKTSFNTQCFCISRDLRMNYCRNPDGNDRPWCYTTDPQPSTYECGKPKVEPKKCGGRIVGGCVAHPHSWPWQISLRRRSFSSWLHFCGGTLIDPSWVLTAAHCLQRSQRPSSYQVYLGLHKEDGESYTQKIDVDRLFTGPMRADIALLKLSRPAQLSDKVIPACLPSEHFPLADKTVCYITGWGETQGTSGAGVLKEASLPIIENKVCNSRLYLRNRVQPWEICAGHFEGGTDSCQGDSGGPLVCFDKDRYIIQGVTSWGIGCALPNRPGVYVRVASYLSWIQNTMKSN
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKKQKKILWKKGIHLAFSEKWNAGFGSFKKFYFPQNLCFLKAKLGRPVAWHRQVKHFQCNKGLHIQKTWIQDVPFCSKTKSGLATQNVSTLYPKVKRKDSKHFISSSRSLLKLQADKLLSSAKSLDHKYCREKSLLKAAPGLSANTVLGRANGHEPTTDPQASDFPMKFSGESQSPGDSGKTVVLNKHRKRVCHGCYQGLEHHRNRRPLIPKQFQLNQHRRVRASLMMYEKLSMIRFRYRIFRSQHFRTKSRVCKLRKAQRSWVQKVTGDHQENLRDNNTEGDNCNPVPSLEPKDPCRCQPYFPDMDSSAVGKGKNCHVPDGHTKENPVLDKEHGLDDTFPDQQNGCVAYNWDQSSSCPKWECTEQIHEIPLMEHPSSDKFSPETERALMALGQESGTSAVSDDREKLPVSGADKSVSSVDGPVSEEPAQNENFQMEEDGSLKQSILSSKLLDHPYCKSPLDAPLLCSEPKVENQMSGGKSSQTASPVDDEQLSTCLSGFLDEVMKKYGSLVPLSEKDVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTLSSRIISFYDSQGIHFKFCVENIRKYLLTEAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIYKELCECRLLD
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MAGNSSAARGARVVGDYVFGRQIGSGSFSRVWHAKHRIRGTEVAVKEIVMDRLSKKLQESLLSEIDILKTIDNPHIIALHDIIKSSGKIFLVLEYCRGGDLSVYIQRHGRVPETKAKHFMKQLASGLQVLREHNVIHRDLKPQNLLLSKDDESAVLKIADFGFARSLKPMVLADTLCGSPLYMAPEIMLLQKYDAKADLWSVGVILFQLVTGRTPYTGSNQIQLISNIKASTELRFPRDSAALSTDFIDLCKRLVHINPVERLTFEEFFEHPFLLQCNNEESTSQQSLHLHQGELLRNSPSKESHRPPLTSEHIRDECIPFTADALPSQPPARTYIPAKDPSIKSTYGFSLDTGLDKRPAACNFSNKIDSTSQYNSKHDSGRISGIAWDKTSSALKDIKSPREQRPTKVFSEDPTMVDSLEFIDREYVLVPGPPLEASSSSLIASKPYNSSCESETSSIPSPKFFALSAPMAIIGVPTNKKCDNESLEMRHCSSSGNSQGSVDMGDTMEQPSSNSTTRIRSLQQCASVITELVNEKVVSGHVVEAFSVQLVILAIWKQALHICHAQAASAIEGRPSQDIQFLRSVDKKKSFDSQECVSITESQQLDSSEIEKAFLEEVENAEVLTSDLGPIDDATEMPDAMEIIFQTALSYGRNGAVDELMDDIDKATNLYTKAVRLLCFLLVEAPSLIVNPPFSLTNSDRLRLRSYIEILSSRQSQYRSQRMALLKSDNNQESLDN
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Might be a pH sensor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEDDGRLAPRQIWARPTSTTTRSYVPGCTPFLLPSDGYVYLNRTYSISLGENAIYDPACTSTPTTTEHAGAALDIHDPFYASVTPLLYAMGCATVVSYLLVIILLITPRTFYVGGPGGGANFLGRHGMVSGSYSNNSSVVGVGGRPWLQKVAALLVAISLTIATADSFRVAEKQYDHGYSDAEALTSEVIDGTEIKVVRIISSTFLWLAQVQTLIRLFPRHKEKVMIKWAGFALIVLDTIFAILDKFLVKTNTTRPRLYEDAIPALSYLFELALNLLYAAWVIFYSLSKHRFAFFHPKMRNICLVALLSLCAVLIPVVFFVLDIAKPEIAGWGTYIRWVGSAAASVVVWEWVERIEALERDERKDGILGREVFDGDEMIEVTPSEEVDWPRQQFHGHDRGGGTGMSSAWGGVMGLAHRPLRPRGGRITQTQREAEGATAAKSRKRRSARPTPPPAAVTPVSRADTTSAASTVYNVHYYPVSSPTPPVAMPFMEEEDEGSDGDGEKELAVVQNQQSSLPTQDTYTEPRRQNSPQIVNVDNRWRFILNPFKNRHAALPREVASAQAEEEGFLSPDDQAPRQGDEENPHYTPRHRGLFSFHPMSDGASRRQSGADQPLPVTVIPARRRGQDTWSPQWFTNSNLVDRSSSRRTASRPRDQRMKVIQPQVQSAAPWTAADMEASFSSMDYELRYDPEAAALVSEDIPDHHSQPTQADSPAHPTMSGGNGPSGGETQSALDTGPGIEGSVNEGSVIEGPEESHSQR
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the first step, a glutamine amidotransferase generates ammonia that is channelled between the binding sites of glutamine and chorismate and used along with chorismate in the second step, catalyzed by aminodeoxychorismate synthase, to produce ADC. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis. Does not possess ADC lyase activity.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MNFSLCSTSSELAWPSDCVTRSPVANRFLSREPVRFDETWKKKKHFKIPRCGTKKVFVEDSSSIAKKSVPRREPVERLGFVRTLLIDNYDSYTFNIYQALSTINGVPPVVIRNDEWTWEEAYRYLYEDAAFDNIVISPGPGSPMCPADIGICLRLLLECRDIPILGVCLGHQALGYVHGAHVVHAPEPVHGRLSGIEHDGNILFSDIPSGRNSDFKADKESLPKELIPIAWTVYDDTGSFSEKKFSTPVNTSLSPLGNGSVNSALETLEEQSYWPSPHVDGKQDRHILMGIMHSTFPHYGLQFHPESIATTYGSQIFKNFKDVTVDYWSRYKSPSLRRRMISETANMQVPSACQLLKELSRTRNTGNGSSYNSNSLSTAKKNGVDVFNLVDLAYAKPHSQLLRLKWKKLERLVHKVGGARNIFMELYGKNRGNDAFWLDTSSSDKARGRFSFMGGKGGSLWKQLTFSLSDQSEITSKHAGHLLIEDAHGSTEKRFLEEGFLDFLRKELSSISYDEKDFKGLPFDFCGGYVGCIGYDIKVECGMPINRHKSNAPDACFFFADNVVAIDHQLDDVYVLSLHEEDTAETSFMNDTEEKLITMSVSSTRKWKDQSLPAIDSSQRKASFVPDKSREQYINDVERCMQYIKDGESYELCLTTQNRWRIGNTDPLGLYLHLREKNPAPYAAFLNFSNSNLSLCCSSPERFLRLDRNGMLEAKPIKGTIARGSTPEEDELLKFELKLSEKNQAENLMIVDLLRNDLGRVCEPGSVHVPNLMDVETYTTVHTMVSTVRGLKKTDISPVECVRAAFPGGSMTGAPKLRSVEILDSLENCSRGLYSGSIGYFSYNGTFDLNIVIRTVVIHEDEATIGAGGAIVALSNPEDEFEEMILKTRAPANAVIEFCSGSSERH
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MADFIDSEAEESEEEEELTEKEKSKLKKMKAAAIDSDDDEEEDDEQMQEELGDLIDDNPIEDDSSSSGSDNETSGGTKRKRDDDDDELDDRLSEEDFELIEENLGIKMKRKKTFVRVKRIVDDESDEEGQERGRDAIANELFEGSDGEDSRRAASRVRQERDEDENLDKYSDEEDEDEEDIGDFIVDAEGQPIHGKKKKRKAIYTDAALQEAQDIFGVDFDYEDFNQEGEEYEDDEEEEYEDEEGIRKTRKKTGVVKKKSQRKTIYDVYEPSELERGHFTDFDEKIRKTDMPERMQLRNVPITSVEEGSAELDLEAEWIYKHAFSKASISNQDGTADGREKVIKGPQTVEKIRKALEFIRNQHFEVPFIAFYRKEYVLPELSVNDLWRVYKFDEKWTQLQTRKKNMMRLFKKMQKYQSEKLTQNLTESIPENVRVLKDEDTDRLRMVQSIEELSDVYNHFTLYYGNDVPAMQEEHRRRAREEAKERRSSAARRRLNEDGEPMDVDDLGEDLRDPDDVNVDEESSIKQAKRSDLYSLCARAGLDGLLRKYGLSPEQFAENMRDNYQRHEVDQTSTEPFDVALEYVSAKFPTATEVLKAANYMLAVQIAKEPLVRQCVRESFFERARIDVIPTKQGLKEIDENHNLYPIKFLKDKPVRDLVDDQFLRLVVAEQDKLLTIVFQTKIEGATTASYVDEIKALFTRDEFSKLVQEWNDLRNEIIDLALSKFVAPYKVDFDDEEDWDTKNGIRVMGLSYVADLDQAAFGCLINVDGECSDHIRLEHILKRKNAWKEMDRTGKERDLNMLRNFIFSKKPHVIAVSAESREATMLVEDLRAITAQLVEDEQWPTINVELVDNSLAKVFANSTRAETEFREYPLLLREAISIARGLQDPLIEYSQLCNTDEEIVCLKYHSMQDQLSKEELLEGLYLEFVNRTNEVGVDINRAINYPHTANLVQFICGLGPRKGQALIKILKQNNQRLENRTQLVTACHMGPKVFINCAGFIKIDTNSLGDSTESYVEVLDGSRVHPETYEWARKMAVDALEYDDEDANPAGAVEEILEAPERLKDLDLDAFADELERQGFGNKRITLYDIRSELNHRYKDGRPSYQQPSPEDIFNMVTKETPHTFFIGKLVLATVTGFQHRKPKREELDRANPNRNETTGLWQCPFCLQNDFTDLSEVWNHFDAGSCSGQAIGVRIRLENGLSGFLPMKCLSDSEVTNPEERVRPGQTIHCRITKIDVERFSVVATSKSSDLMDRNGEWRPPKDAYYDTPAEEAILKAEEDSKKLKHRQSYTKRVIVHPSFKNIGFKEAEKLMTSMDQGEVIVRPSSKGTNHLTVTWKVGEGICQHVDVREEGKENAFSLGQSLMINDEEFEDLDEIIARHINPMAGHARDLYAFRYFRDLGVPEENYTAGKERERAEEVIKDDKKKNPAKIHYFVTASRDFPGKFMLTYLPRTTAKHEYITVTPDGFRFRGHVHDSLASLFRWFKEHFRDPIPGTPSSRGGGVGHHASSSRTPGYGGTGTTPNVNPETLQRVAQSIPANMLHSLSQAAHFQGTPTPFGYPANTPYTPSGTTPFMTPFATTPHQPQTPRYSGTPATNAAPSAGGSQGTSKTSTSRSAAPASSEPDDWNAATNAWGSVTSNRTAAKTTPNTRPASSTPRGKTTPSTSRAGTSTDDWGAPSKTPASGRSPRQMEMGDATPLYDE
The following text describes a protein:
Function:
Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Sequence:
MEGTSPFFLGLDASTQALKASLLDVDLNVLSELEIRFDRDLPQYKTTGGISAPAADDDQGTVVAPVMLYVESIDMLAERMRSASWPLSRIRAISAAGQQHASVYFSRAAPRIFTTLSAEKTLTEQVEQAFSRKVVPNWQDSSTVDACKAFEKAVGGAEKLAQMTGSKAHTRFTGPQIYKFRTQQPQAYKDTERIGLVSSFITTLLCVGQGEDESSVIKGIDEADACGMNLLDMRPASSITATKGRIEPGWNQTLLALASGESEGSDASLGGAVELERKLGSIYRDAGTPVAKIGSWWTKKYGFSPDCHVFPGTGDNPATFLAFSLAEREAIISLGTSDTVMVATHQFVPDPDFHAFFHPARLPSSGDAFFNMLVYKSGSLAREWIRDQYCNSDWAAFNADVEKFKLQQDGEQRAGFYWLRPEIIPPGASGIYRYIKPSTCGEWQKVDDFSDKGMNASGILETQMLNYRYRSSSIVAGPTTSSGSAVDTSVLPLQAIYAVGGASSNPTITQTMADVFGCDIVKPVQPAQDGKEWTPANYNFCSVGAAYKAAWGWSRLQLKAGEKVPEFDEFVHTTKSSQAKRAGSVREGTGEVKGSVQVICRPTEGRTQVYTNVIGAWKQLEERAQKEQ
The following text describes a protein:
Function:
May function as a transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MMDCDEQKFDALDDTPETVVAKQKPQLHEVVRTFVNLMEIKKESDSSQVEITPVPIPPLSNCKLMKVSSTEKPAGSSLGFTVNGRPVNTPSGGAELRLCSHPGGSTSGFTSIQIPVTLTVHSPAGTHFFNATGSLNSSVTSSRLSPPPSPGEHDPSPKSDPIPIITGVVSGEAAQKVLNDHNVNFTSDSPSQCAPFPSGGTSPPKSSLPQCTPPAVPKQKGLNSKPAANKLLRKGEIEPATPPKCKACGAQYKLVTELRGFMCLCSPSIALSLRNMKRRSINQKRRNRSKNQTQKNNKDPQSSNKGFSIWAGPPAAKDAAPPPKIQRTSDEDFSSLTFPSVSSSSQDQDLPKPTTEIAEAKMVILLEDFYYGKDPGRSGSQADLTGGRSSGPFTCIICSQSLLNNIKLMHHMQQHVTMMSKDEEEVDPVPSCSHCFRNFPSSSKLQCHLEAVHICSKSVALCRICELAFEDEPAFMRHMKTTHKPGEMPYICQVCDFRSSFYSDVWSHFQDTHANTKHLLCQFCLRVLRSNICYQQHFARHQRKHKLSCDKCRLHFLYVKERVEHNALCHKTHIKPPQLCGLKPGTKVTVRMYAMVGGPKSQNGVLKSITPCKVVNVSSPPPIQEAPKKNAVEGLRLSGLKTDRASQSCIECLASVPDFQRHFPSVVRCSLCRFVTCCSASYANHMINNHTTSRRARQFPVIFQPDPRLSEEVICVACSLSSFRGDVIANHLNENPSHGFARILSKVSDQSEEEAKKCSSDRPTVTLSGEGKFVPIHLVPSKEPSKQLTIKPLNSNSKPSFTPAMTVKIMASQPDLEKVVTSPDLEKPQTSTLSIYNLSVILSSMCHGVAQASRRFQTRPGVIRSWITRQQRGLLKRKWRWKTDKMAEWVLNRREQQLTVGEDVLLLTARATLGGSCKLEEYYNWTVDVMLRHDLGVQTTNNHKLHQIELSSHFFLKTLFSQVQNLAVPLHCLGCMDELPVFINLDQFSNQNPSAFQLFTSHQEKPVIDIVLCGLSDGSFLPPMLFYTGAALHVPEGFPDNVLLESRQQGFTEEERLALWVQKVWCPNVASKYKQASILLMDVHRGHLSTEFQGNLSSCQTQTAVIPAGCCCRLQPLDVCVAQVLRDHLMARWNQLVAEGGLDGLGLDQLALMLACWVSEASFTLNSKKKILHKSFSLTCSLDHSEAPGEAARMITALSEALNQPPEAEKAEPKVTPSQVKETKTDQREKEAPEMRENEEEEELCIRSPSHLRQVFDGDSDEESFPGFPDC
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MPKSSILRVQVKGDDDYAGLSFGFYNKTCPQLEKIVEDAISSMSKQDPRTPAALLRLLFNDCKVKGCDASILLDVYERSKSEMGSFSNFGIKKRELIGQIKSMVDKICPNQVSCADILVLAAREAVAVSQGPKIRVPLGRRDSSVAYTNYDADFDLPPVDTFIRKSLGFLENLNVGLTIEEQIALLGAHTLGTSHCATIQYRFDAPWIINTDKEFYKKLQKICPKGAASNFNTSLPNDRTPYVFDADIYVESLRGRGLLVTDVDLSDDALTAEIAPKFIFDKDYFFKTFSSAFVKLSTADVLTGNDGEIRRQCDKLNGV
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAVSSWREKVVAEVGDIPTVLVQNKIDLLDDSCIKNEEAEALAKRLKLRFYRTSVKEDLNVNEVFKYLAEKYLQKLKQQIAEDPELTHSSSNKIGVFNTSGGSHSGQNSGTLNGGDVINLRPNKQRTKKNRNPFSSCSIP
The following text describes a protein:
Function:
Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQQNKRLITISMLSAIAFVLTFIKFPIPFLPPYLTLDFSDVPSLLATFTFGPVAGIVVALVKNLLNYLFSMGDPVGPFANFLAGASFLLTAYAIYKNKRSTKSLITGLIIATIVMTIVLSILNYFVLLPLYGMIFNLADIANNLKVIIVSGIIPFNIIKGIVISIVFILLYRRLANFLKRI
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MTAHQIEGCTWQSTWQSMAAISTRLSLKLKQERKRKYEESESNKSVVVIDLTEEDLPADPSPAQASVVSRVQAKISKYFDKHQNHQLTDGAVVSANRKGKAVNRSTNIQGKDDKTKAILKENKLKHNDQDNGANCESSQACLQKDNTQRFDYQELAKDKCHTSTDLMVTRSSRMENLSLMECTSPSSTIDSRRSISAKSKITRRVTNAKGKDDRTKATYKGKHSNHDDMANKTLLQDSTTSLEEDKTQQLDCQVLVQDDHHTSTSSIVITPPTNEITSTIQNTSPSLTVDSSRSVITKDKANHKGVDIKGRGGRTNTIREENMKPKVKYSNQSDMSNSSPRQNNQVCLEENKIQQSDCQVLAQDECHTSTNPTVIKPSTNEIASSIQSASPSTAVVIASQEKIDVGPQSMVKVEKSEELTPVSAPAGIPQNDDQTHQTSQKEPYLPYYLSNFNIIIQTVRNCKDDVCLFNDEDLVAVDSFYNLSVSAQKLYVRLFLRVYTWFQCSKLKYPDIREDLSSDIEQLRNAGLVEDDDSLTDMEDILNLLPGPEVKKLAKMYHVKSGSKNNIIEALKKLGRQQRGVYGQQVEGVSGITRSVIKRAKSVLGLCIRLQKHPRCVFNRMSLLFALTSATYDDDLANGGHAQMAQLMMVNFGRLVYPEYEIYRPTPVFTCREDFITYDSKLQEYYDINEAFARGDVDTALQLYHDVYDDCKSIINDLLNDENFIGRQLPSYLMQYTPGWVCCQILSSGIGLLEKKRMYKEASMELQYLLQQKVFCNVRRGKWWDRLALILEQHLKQPELSLNAVKEALVDPCIGGGRKLALQQRGIRLCNSPSNKKLHIYRQDIPQINLKDANHITITGRLYPAVGSGYKSVFIRPGEDCSFLCSVEELALYHYLDNEGFTDGLHAEGATLSTLYTLLMWDILFTPGVPDVFRHPFQSAPLDLMHGGFYSNRKDIIEEKLRLIRESDDQGIEDMIKSTWTRYEGRICVGINWERFPNGLPQVQSLALCFGGEILADLCERFSKSFAAGGLPDLVLWNKETKKVKFAEVKGPNDRLSTKQILWIDRIVNWGIDVDVCHVKAIGSKAL
The following text describes a protein:
Function:
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Note=Cell periphery. The polarization of EXO84 requires actin cables (By similarity).
Sequence:
MESRGLTLRSRTRRARPQISAPKPISGPLPPNSKSTDSGQGNNVSQAVSRERIPTNGATSDLVKRRYSTRYNQAPEFDASAPPVPGLPAAASKYGGLGPPEASKKPSSDSSGPPQVDLNALRDPSLPVDRSNLLANATEEEIEEYQNNLRKVRNRTSTDLQQNVYQNRTQFIKISKEAEKLKGEMRTLRTLMAELTTALGQTAIGNAPNPMSPTADDWVPKRNANRSSVANLESMWNVQLQTLWKTVEGSQKFLPVAPGRHIVMETGQWVELDSATWKPRRPVHIVLLNDHLLVAAKKRKRVDASNHRGPVPTKLVAEECWPLQDVDMIDLGANMGTGAAREEAEERGIANAINVRVGSKTFTYRHDKRDSSDKGELLATFRKAVEDLRRTLRSESDTAIKPTDGFGYAGVKHSVSQKLDLNASDASRDKPEVRIDVDGKQQNLRWVDGQVDELDIDIALQRFEEAVSGIERLRKLARGLKGNSYAQQIINSKVDERAARLASVLSRALADTHSFLNATKTNVTWLTRLGFEDQAREAYLKARSDVISKRVRACVFEGDLPLYIFQVSYVYFTLIKNTINIYQQCFPAVLTSACIKWAKHHLDGFNALLTRQLSSVQRGTTVWQKCIDIVHEHADSLTEVGVDFVDLVAKGLDLHDNGGEKPQMTRSESLISGLADAARDHAF
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MMRRVLSKFTRFRTVNRHLATQSSPVVLGIETSCDDTGAALVTGNGTVLGEYIHSQQSSHLRFGGIIPPVAQDIHRANIESVVQNAFKLANMTPNDIDAVAVTNRPGLPLSLIVGMRYAKHIARSYNKPLIPIHHMQAHALMARMTSTIPYPFLCLLVSGGHSLLVFVESTARFRLLGETLDDAPGEALDKIARRLKLRNVAKYAQMSGGQAIEAAAQQAGAKDTSAYEFPLPLSKYRDCQFSFAGLKNTATRHILERESTLHLAPDALLPDYEAFCACFLKGVTRHMLHRTQRAIEYCERRKLFSDAEPHRSLVVSGGVACNDVIFNALSSMAAQFGYSTYRPPKKLCTDNGTMIAWNGMEKLLAKDTAEMTTKYEQVDISGKCPIGDSLIDDVKEANIACKWAKVDIFPGKEEVSS
The following text describes a protein:
Function:
Ligand for the receptor complex composed of ilcr-1 and ilcr-2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones.
Subcellular Localization:
Secreted.
Sequence:
MPKSPHRTNLQSFYPIMIILTHLALDSNCWRIRREVDGEEEDIMPSEECYHKYNEENHFKVFSNYLNRKNSSHYSPIAPSYQQALLRLQVKGLKHGEQITKSSGKCNSKKLDTISAETPLRDRALCKFEYVLNYNPKRLPAALTEVKCSCPRPNSKLVGKRIFECEHLRYQVRVLMWDDSCNTFREHVETIALACIPVIQANANADGDDDFIYTIKAEIPI
The following text describes a protein:
Function:
Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex; Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems.
Subcellular Localization:
Cell surface. Secreted.
Sequence:
MTFSLPWLSRSTVLETMAPLLALLALLQLGPGLAALSCPQNVNIVGGNFTLSRGWAPGSVLIYSCPLGRYPSPAWRECQSNGQWQTPRASSLPTLRSSRLAKAVCKPVRCPAPTSFENGIYIPRLGSYPVGGNLSFECEHGFTLRGSPVRYCRPNGVWDGETAVCDNGGKSNMGGSPKPAVDNIREILGISRNRNDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDAKAVQQVFEHILDVSKLTDTICGVGNMSVNASDQERTPWQVTFKPKSKETCQGSLISDQWVLTAAHCFHDAQMEDRHLWRVIVGDPTSHHGKEFHVEEVLVAPGFNVHAKQSQGISEFYADDIALLKLSQRVKMSSHARPICLPCTVGANMALRRSPGSTCKDHGECWRLEVLGGLRQSLLAGCQQGWGGLQSSSWTHQLWVKRPVSTSPFSPTAETELLSQQKVPAHFVALNGNRMNINLRTGPERTSCIEAVSQNKGSFPGLTNVSEVVTDQFLCSGMEGDDSPCKGESGGAVFLERRYRFFQVGLVSWGLFDPCHGSSNKNLRRKPPHGVVPRDFHISLFRLQPWLRQHLDGVLDFLPL
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
Sequence:
MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTARTGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGGRLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGAITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPGPRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIASPTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRNAPTVLTPHAGEFARLAGAPPGDDRVGACRQLADALGATVLLKGNVTVIADPGGPVYLNPAGQSWAATAGSGDVLSGMIGALLASGLPSGEAAAAAAFVHARASAAAAADPGPGDAPTSASRISGHIRAALAAL
The following text describes a protein:
Function:
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system. The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA. The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB. The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone. The cyclization of the last ring could be mediated by the lactamase-like protein vrtG. The proposed post-PKS tailoring steps are a hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF. VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin. Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin.
Sequence:
MATRIPFDESYWEEYLSGQEASLPALPAVTQLSPRVTRLLAGNPGIMQLQGTNTYLVGTGPARILIDTGEGRPVWHATLAEHLRTHHLTLEYILLTHWHGDHTGGIPDLIAHDPTLQSRIYKHHPDRGQRPIRDGQRFTVTGATVRAVFTPGHAIDHMCFLIEEEKALLTGDNVLGHGFAIVQDLAEYMASLARMAALGCERGYPAHGAVIENLPAKMQLYIHHNEVRVQQVITALASVVKLPGKRVGMTVPEIGRAIYGEVPREIVENAIVPFLSQVLWKLAEDRKVGFEPGEANKRRWFGLVTQQ
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MSSSASKSRVVRLRSANNEIFEVEEAIVALSEPIKNLIDVIGVNHVIPMPDVRSKTLAMVIEWCKYHAASDQGPRNTKELIKEWEEELDQADLVIDLLCTASFLCIKDLQDQMFQRVADLIKVKTLEEICELFHVKNDFSS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MLPEKRISSPDDVERFKSTSAYKKLVSFVQTLAHDVEGSTIQDVGPGSEAVQRIVQAIERLNALIDETPPAEQRARFGNPAFKDWFAKMKELVPELVDSIVGAANQGHVEELSLYLSESFGNATRIDYGSGHELNFVAFLCCLALLRVVTPQDGRGLCLVAFNRYLALVRRIQTTYNLEPAGSHGVWGLDDFQFLCYYWGAAQLVGQDDMVTPKAIPDEKAAKAHGEANLFFAALAFIHRTKTGPFHEHSRFLFDMSGAASWSKVYKGLFKMYKDEVLHKFPVIQHFFFGSLLPFEAGSGQSTPVGVAVTTPAPTARPVDPARAAPGEMPLTGFPGRGGPTHFNPDLVRGPPVEMRTGTARVAETGSFR
The following text describes a protein:
Function:
Defense against chitin-containing fungal pathogens.
Sequence:
MSVWAFAFFSLFLSLSVRGSAEQCGQQAGDALCPGGLCCSSYGWCGTTADYCGDGCQSQCDGGGGGGGGGGGGGGGGGGGGDGYLSDIIPESMFDDMLKYRNDPQCPAVGFYTYNAFISAAKEFPDFGNTGDDLMRKREIAAFLGQTSHETNGWWPAAQGDQYDWGYCHMNYNYGLCGDDLNLPLLQEPELVETDPFIAFKTALWFWMTPQSPKPSCHAVITESWTPSAADSEAGRVPGYGVITNIINGGIECGQGGPNNANENRIGFYKTYCDSLGTTYGSNLDCYQQRPFGYGLLGLKDTM