lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDKEANGDGGKPVESAPTAAPSSAVVVSEQEKQLAATATAEFNAGRYASCIEALDKLRALRPTDGKVAHNRAIARFYASGKKNSEELAQDMTEVASLLHVNLASPDSLDDVDQCVPFFNHAVSLYHAQQYRKAVAILDRLFQFIEPLDESVTRKICFLYIELCLCLKQPEKVLGLIAYAESLVFGSRAAAAGETASPLEKDEEPREPAKLGAHWTRLQQYKTRCFMLLRSTKASKREIKSLVNSGAPTSQTVFLRSQLEFMRGNYRKAVKVLCTAQLQGDPKVTAMYHNNVGCVHFYTGKPHLGSFSFDKALRAYHEGAKAGVFDNRMYYELVYNLGVQNLHAGRYVAAFDCLVEAVRFQPTNARLWLRIAECCVYRHKSDNAVDFQLKERKLNMVRGTVGSGPYRKIVLAPSISTDRYVPVGSDHSAAIPVPTLEFATLCLKNALLLLPETAAPETGSSTGVAGGDDAAQPGNGGAAGSVQTPPHVLDEVAALRNSALALAAYVALCLNDVVIALEHAESLLSQPRISGIHSFLGHLYAAEALLLLDRVPDAVEHLNPDLVTDLSYGFPGEADDSGNNKDGSKPATPEAEDKAYRKPWYPASTSTARVISLYNLAVAYTLRGGLSKATETLRLVSASKGQDPEIPVQALMLAIYVQLQQGHADLAKSIIKQHLPQYK
The following text describes a protein:
Function:
Confers resistance to fosfomycin and deoxycholate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQVSN
The following text describes a protein:
Function:
Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MNHKNVSNLRYVLSNLVPKEQSRIKNFKTQYGKTNIGSISVDMIYGGIRGMKGLVYETSVLDADEGIRFCGYSIPEYQQLLPKAPGRAEPLPEGLFWLLVTGQVPTDEQVNWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQFSAAITALNSESSFAQAYSEGVNKAKYWWEFVYEDSMDLIAKLPCVAAKIYRNLYREGSSIGAIDSSLDWSHNFTNMLGYRDATFTELMRLYLTIHSDHEGGNMSAHTSHLEVLVWLTALQKEMGGEVSDEAMRDYIWNTLKSGRVVPGYGHAVLRKTDPRYTCQQEFAFKHLPDDPIFKLVHQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTNGLMTLVGANNSGKDEVSKEEGGEGKEEQKGQVEGRGMHKMQYTYEKKGLCWIYVNNYCSLEFFFFFIAVCLWRCGCCTFFT
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (By similarity). Involved in regulation of antisense ribosomal siRNA production. Involved in response to cold-warm shock.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=As a part of exosome complex, translocates from the nucleolus to nucleoplasm in response to cold-warm shock.
Sequence:
MSFEVTGPPLVSPWMMLSMSEARNDIDETKIVIPGHSVCDAPQQFMRGHGTYVRDGEIVSSLSGVVQQLNRLLMVKTIKQRYAGEVGDVVVARVVEVQAKRWKCDVASRLHANLPLGSVLLPGGDFRRKDVEDEEKMSEFLKNGELICAEVQQVQHDGTLMLHTRNNKYGKLQQGILIKVPPHLIKKSKKHFHTLPYGMAVIIGCNGSVWVTPSLPETTLEEDGSHVHEFQIVPPDVRVTMVRIAACVRLLRDYSISIYLNSLTTCYEMSQPYEIKELAEQDTSSRLAYLIAARLLQELQQQK
The following text describes a protein:
Function:
May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
Sequence:
MFIRIRSRDGLERLQVDNPNITIAQLKTLIESQLRVPVHNQTLSTNQSLLLAKTPTEMSRFSDMSNAQTLISTLGIAHGSIIYLAYEGERTVAGPKIRPAGSFGRKMTMDDLIAKQMRITRQENPHCELVSFDRDAANGFQHYVNETLAFAVKRGGFMYGTVSDEGKVEVDFIYEPPQQGTEDNLILLRDPDEERLVEAIALGLGMRKVGFIFTQTIGQTKKDYTLSNREILQAVELQGETDLKEWVTVMVKLEVNDDGAADVHFEAFQMSDLCVKLFKDGWFETEIAADAEPKLSKMKKDVVVGGKDTREVDNDFFLVVVKIFDHQGPLSSTFPVENRNTAITMRTLKNHLDRTKNFPFVKRISDFHVLLLLARYLDVNSDVPALAGCVHAQATVPEGYQILIDSMAASA
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGSSEEPNRPISFYDSSSPSAPLLSKPPNPIDDPPPPPPSSPPSYTDQPDSESDPTQYLQISYNHGPRPFKDLPFLIIFVLFVLATFAFGIFSIFHRNTSYSNLSSFVYDSDSTSCVENDTLTHHPNWILLTFSSSSSSFLKDLTWTLVITLILSLPICISLLLLLKHYAKQVVYVFLPFFIVFPIFFNVYWFVACTLSSTCSDALPLLYRILILIFVFLVIGVLVWILVVNWHRIELTVSIIGVASDALSRNLGLFGVLPCLTLALVVYYAPIVVFLVFARLNGKIVPRESNDVYTCVWKQDSWVPAYYALAILTMLWSLTTMVEAQVYVISGTVAQWYFTKEDSTPRRIIRSSLRNAFGPSFGTVCVSGLLLAVVRVVRAVVDGARREGAPGMVNFVLRCCVNALFSAIDFLNKFTINFAAITGEAYCSSARMTYELLKRNLLSAVFVETISTRLLAGIVFVLSAIYAIAVCAILKGVSNLGVDSYFVALLAWVLLILVLGFFVHVLDNVIDTVYVCYAIDRDRGEVCKQEVHEVYVHLPISRNHRPSSIISRTLGV
The following text describes a protein:
Function:
Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
It contains a N-terminal DNA binding region and a C-terminal metal binding region.
Sequence:
MNISDVAKKTGLTSKAIRFYEEKKLVTPPVRTDNGYRSYTAKHIEELTLLRQARQVGFTLDECRELLALFHNPARHSADVKAATLLKVAEIEQHINDLNQMRMRLLALAEECPGDEGADCPIINSLAGCCHSSSSLPLK
The following text describes a protein:
Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.
Sequence:
MEKPELWVALALLLCSYTCGSQDLQVIDLLTVSESRQMAAVAEKVRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTALLRLRGPSRPSPGLQLYVDCKLGDQHAGLPALAPIPPAEVSGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQGDESIHNAVTSALQSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPSPCFRGVDCMEVYEYPGYRCGPCPPGLRGNGTHCEDIDECAHADPCFLGSSCINTMPGFHCEACPQGYKGTRVSGVGIDYARASKQVCSDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCTPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDTCDSCPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MQCTRAAQRANLTGFDPKALAAASGKNAGDPWARREAWRYQGQYSRRNRFSNSFPGLGIATVAFTVYCGYEYFFIPDDHHSEGAHGAGHH
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MSNFAVHLVQYVGFFLAQFTNALLLCIIANKAKKLFGGYRYVMIVFVIYSLIYSWIEIAATPLMYGHRSMIIIMVGSSLRYEDLAGTFIICLFCAAYSLMTALLATQFFYRYIVVCRPQFLHHIKGYKLCFIFLPGVVIFFLWYLNVHFGMKKTLEKAKFSQEVILKNCEEDTFQIVFVALQYWEDDLNGKSHFRIIDFLSYLGFLLMIALCFLTIIFCALKIYFKLKEDIHSMSERTKELNRQLMMTLTFQTIFPFFTMYSTVGAILTLPIFEIELGKLASVTGMLSGIYPAIEPVFAIFFVKEFRNFVLCKKHFVANVIPLQHLPVPRNSLMTAHASLQNLSIP
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MVADDILRKLTFGVKKPNKAKKADDSKKSSEKELRLRIVPEEVKRVLREEVIEEKEDEEGKIEEESDSDNDSFTILTGSKLASEVDEAKKQKRKRRKEGNTAEHRQQMIARLRRVNRMFSWGDDIPEPIIDWTDLPEITDRIRSNLTSSGIIDPSPIQMQSIPMMMKRRNVLASAPTGSGKTLAFALPVILDVLKYRSGVATVETANPAPVPAAAALVQMPSKKKAKLAEKAKIKDQPEVVVSKDRVLAIVLEPTRELAKQTYRQILKFAEGEDVTCALLEEGMEVEGRNDILVSTPNRLVHRLEKMDLSGLRWLVVDESDRLFDNTEGDEKCFRNQLAAIYKACDASKDVRRAFFSATFSYEVEEWCKENLPAVAMLCIGERNSSNTSVSQKLVYTGSEQGKIVALRDLLYTRFEPPAIVFVQSKERARQLMSAISSMATAVPTTLITSEKSAEQREAALESFRSGRAWVLVCTEIMGRGLDLPAVNLVVNFDLPASIVSYIHRVGRTGRGGRAGAALTYFTEHDMAMVRPIANVISQAGFEVPPYTLLLKPPTKKDKKYALKHAPRRNDVAFIPRKQNQAGKRKETGEKVKQGGKRAEKGDKKDGKKKEGEKTKINRVTEGKVVKKVIKKKKKVVEINETVHMYNRIALVGFQLRNPWIRRGSKPCYLSGQTPPKQLRAWDVEKREELDNMAASFRAVVASKNRKIKDLEEDLSRLKIKSLEEQLKATQNSGRVVPIDNGVQMVKSSKICYQKTQMTSGTVRARFAGITRLQTVNVSQGSVRVAGLNWGIDIRANMDKLGGKKFLAVFLAFKTRPVSESWSAKAYYTIKMINQDCKNKSHVRADNESIYTSTCPSWGLRKFISFEDLLNPANGYVKDNSILLEIDFIVFPAQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MADRLSQLQDAVNQLAQHLCDSVGVLQQSAPLSYFDEFESHDRGLLSIQWMQTNQILYSNTVSYLAVHNPTTNGENVENNLDVFATLITRTAQDIDYIITSLPDIRVSQQNQEKAIERLQEENAQARQQLVEAITRAEGVLLKVKQIKNQVAAAQLEIDKRVNCNERIEIGQ
The following text describes a protein:
Function:
One of at least 4 proteins (Era, RbfA, RimM and RsgA/YjeQ) that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Binds the 30S subunit contacting the head, platform, and rRNA helix 44, which may assist the last maturation stages. Removes RbfA from mature, but not immature 30S ribosomes in a GTP-dependent manner; 95% removal in the presence of GTP, 90% removal in GMP-PNP and 65% removal in the presence of GDP. Circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover. Dispensible for viability, but important for overall fitness. The intrinsic GTPase activity is stimulated by the presence of 30S (160-fold increase in kcat) or 70S (96-fold increase in kcat) ribosomes. Mature 30S ribosomes stimulate intrinsic GTPase more than do immature 30S ribosomes. Ribosome-associated GTPase activity is stimulated by RbfA. The GTPase is inhibited by aminoglycoside antibiotics such as neomycin and paromycin streptomycin and spectinomycin. This inhibition is not due to competition for binding sites on the 30S or 70S ribosome.
Subcellular Localization:
Cytoplasm. Note=Associates with 30S ribosomes.
Domain:
Has 3 domains; an N-terminal OB-like domain (about residues 1-100), a central, circularly permutated GTPase module (residues 104-270) and the C-terminal zinc-finger domain (residues 280 to 350). The C-terminal domain has 2 regions; the zinc-binding domain (residues 287-319) is required for binding to 30S ribosomes while the extreme C-terminus (residues 320-350) helps remove RbfA from the mature 30S subunit.
Sequence:
MSKNKLSKGQQRRVNANHQRRLKTSKEKPDYDDNLFGEPDEGIVISRFGMHADVESADGDVHRCNIRRTIRSLVTGDRVVWRPGKPAAEGVNVKGIVEAVHERTSVLTRPDFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIVLNKIDLLDDEGMAFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGLQKEILTNDISDNSGLGQHTTTAARLYHFPHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGLCKYRDCKHDTDPGCAIREAVEEGKIAETRFENYHRILESMAQVKTRKNFSDTDD
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MEFEKSILNKRSDEAKPGTAADDRHLMTFHCQHCYTVLADSLDVCGELQSLDSVILLKVTDDVVVGDAVMSKDKGEMTNCISSPLKCSHCHLDVGKILHSSPPSLAPVRSLFLLDKSSISCYILNSSSMVKASGLSFDLQPVSERLAEVKQHFEAHLEKMSILKSRLADMSIIRNKKRRVNTKPDKRLTHNKHAHFLPLECIVSTLDHQNHILVTA
The following text describes a protein:
Function:
Dioxygenase that catalyzes the alpha-oxidation of 2-hydroxy fatty acids in an iron-dependent manner (By similarity). Involved in metabolism of phytosphingosine and is required for proper endoplasmic reticulum stress response (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTYLSRSYSFYAAYHSNPVNIKIHQVCIPLLLLTALVLLHNFVITLINSKLQINVAHLVGLAYQIFYVTLDPLDGLLYSPVLYLFSYILPSKLFTIFSRSLVNRSAAVVHVICWILQFIGHGVFEKRKPALLDNLIQSLFIAPLFAFLETGPFVGYYPSVVSKIRANIKLKDVGENYPNLSEFLFPPSMVEDAVSGVVEDASQLSYCIRPLRLSDIDDGIVF
The following text describes a protein:
Function:
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. During early development, required to specify the left-right axis by repressing expression of FGF8, leading to negatively regulate the dorsal organizer formation.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
METEADTAKTFWSEVDVDGVFDELMEVLRRLRHTLRHNTATDREYVQAMRIVQESKLIRTETEDVLLDEDILTVTVSEPQCSPESLQNGIEPEDPQHSTARLYSDVGVVCSHMSSSRPDPAAPLVFQPHVCSSACVPHLPAHTHHLLGHNPLRAPLLCHFQRVCDDAGVVYKAPCGRSLSCMQEVLHFLLQTQSVCVLQTDRFSFSTQVCVERQVCAAPLLERDLSRGLEPVPVALVNTVDGARPREFRYRRERWPHGCFLSAEPLYSVCCDCTDGCTDAHSCACVRRTAGAAYTHQRLTHTLRTGLFECGPWCGCERSRCENRVVQKGLRVRLQVFRTPEHMWAVRCRDDLDAGTFICIYAGVVLRLQQSSECPAERSGEPAVSDDEVQLVEEWRIPEETHTHTHTLDSSPPLHVPVIQRPAEHSLAQRRDQQQFSISSETEDNRCEQALRKKPRLMESNGLQDSRTHTLTHTHDGVYYLDASREGNVARFFTHSDDPNLFIQNVFTDTHDPQFPLIAFFTCRPVKAGTELTWSCTNTEQQKTEEKHCSV
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
DLRTMIVGIVLSLQTALGILGNVSLLFYYLIIYYNEHTMKKIDMILIHVFTSNFLTILSKGLPEVVKAFGWKQLFSDVGCKLTNYFQRLARSMSISTTCFLSVFQAITISPRNSCLKEYKTKTTKFMGLFFSLCWILFILVNMLFPIYTATNRNKKNKTQKRDFEFCHSIGRDKLVDIMYTAFCVFPEVIFSLLIVSSSAFMIFILYGHKKRVQHTLHIHASIRNSAENRATHNILTLVCTFLAFYTLSSILQGYIALSNNPSWWVMNITAIISMCFPTLGPIVISPDFAISRFCFT
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Sequence:
MAAATATNLDAPSQTTPQAADASTSTQFAPVNIGTRNSTLAQIQARAVAAALKSAHPERTYNICPVVVEGDRDKITPLQQLSQGENAKSLWTGELETMLEKGDLDIIVHCLKDMPTQLPDNLELGAILEREDPRDALLISPRLPGDTTLATLPQGATIGTSSVRRAAQLRRLYPHLQFADLRGNVGTRLGKLDKEDSPYSAIILAAAGLRRMGLESRITQYLDSATGGMLHAVGQGALAIEIRKDDETMKALLNKIACERTTRACSAERALLRALEGGCSVPIGIETSWRGGKGLAVGAQPAKDYDKHGNAVEEAEPDLDDQELVMKTMVVSVDGKDAVEHDAVRKVRSKEEAEEMGREVAKILIEKGADQILKKINVEKQWAAKKQLEELKAKTAS
The following text describes a protein:
Function:
Electron transport system for the ribonucleotide reductase system NrdEF.
Sequence:
MKRSYTMVTVYSKNNCVQCKMTKRFLDSNNVSYREINLDEQPEYVDQVKELGFSAAPVIQTPTEVFSGFQPGKLKQLA
The following text describes a protein:
Function:
Component of the sperm acrosome membrane. Required for breakdown of the sperm plasma membrane after sperm entry into the egg, which is an essential prerequisite for successful fertilization.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Has diffuse cytoplasmic expression in primary spermatocytes. In post-meiotic spermatids, detected in clusters of vesicle-like structures adjacent to the nucleus. In late spermatids, a single vesicle-like spot is found near the nucleus, which probably corresponds to the acroblast. In mature sperm, localizes to the apical tip of the sperm head (acrosome).
Sequence:
MLSLLTRPFLPIFCFLYGPQSEGSTRIQCLRRFVTFLLGLVLGFLLWKLAALNFTLGRLFVNGATDLYVFIIFVLVTGTIFMLSLPVRAVILLIFVALVGKSGRTYLRAVAFAFIISGPIANLVENAGEVARVFVCTTVLTYNLSKTRFDLMAKPFTNTLKHMRGDVEEIRHTFYELQEVLVDLKYAVENSDIEDEKYGDKNTKPIYERWGRETSRMNVSEIGNGGKELPTPAAVQERFQRNMRNRCKHQLRSGHRACLEVFRNGYRKCTTNFPSMIAKAICWPYRVDIICELDLFGNPDKICDPSAVVPQNFGETYVELLKAEKKLFDNSSQIVVNYEIKDEQFAKSQLKSAERTGQAFKEDFERQKRIFNKVMGILQKILCLFMLRMVYVSINYYVKYLNDVEFDNFYITKYFKHVDQRRKEQRIDAILPLRTYEKSKYIDVDHIFSRTHHESTTVCFNLLQFLLELVTAGLFILIDHLVVELLQIVRKRSKIVYQQDGEHEVRFNISGVGQMARLLRTTMHNFNIHEKVSTSLSNKECLPNAHVLPKKMYYQLILLYLIIIVLIYQSTTFLRMRRVICSFFYYKREKQRILFLYNRILRNRLRSLEFLIHDAEDNLATHRIQQQVNVFLWLRFSCPVAFGWIRHFKFAKRTCMICRGLEDSTFTVCGNCGLPYCDDCAEDLNSVCFQCGVVLTRGAEGSESSVEVYTYRKEK
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEEVVHYFLEGNMPVAQFREALALHYTNEKELFEQAKRCLNICCGSNNFAKRNDVLFSLLDVAVSISSLELRKELISELYVPVQSLEEAPSEYLVSCCLQLATIYEAEQNFELLCSSLEAVEKHGHFENDLEQLLLLRIRLGDAYLKLGKAEKAILTVRTSIPLAFKVSNDQLLMELQLCNARALDETGQFLEAAKCYYRVLQYKVPGNELIYRENLCSVAQCLLLAIPSPIVLQFLQEISLQPSVREIPFYSLVEKYLKRKFIGKEDGAFLLPFLLPHQVIHMNRLIEDGRHFLETNILFLSEFFEVSSTSILAKHFKLSEEQVDTVVADMVIQERLNASIDQCEGYITFLPEYGKANNLPNYVNKIATVLQHYGS
The following text describes a protein:
Function:
Is toxic to insects. Reduces amplitude and frequency of spontaneous firing and inhibits voltage-gated sodium current (Nav) in the dorsal unpaired median (DUM) neurons of P.americana.
Subcellular Localization:
Secreted.
Sequence:
IIECFFSCEIEKDGKSKEGKPCKPKGDKDKDKKCGGWRCKIKMCIKI
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 5700 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MSFIQRRLLSQTLFLRSQVGSLPLYISPEVQVSINALSMPRIIRKGRTSMNISQNITVKGPKGELSVEVPDFLHLDKDEKHGKINVTVQNSEDKHQRSMWGTVRSLINNHIIGVTEGHLAVLRFVGTGYRAQLENDGKFVNVKVGASIKQGLDVPEGIVVKTPAPTSLIIEGCNKQQVLLFAAKLRKFHPPEPYKGKGIYVNDETIKLKDKKIK
The following text describes a protein:
Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular Localization:
Nucleus.
Sequence:
MHQPGSHQIQPIDSLTPFLGGKWWIRARVADKSDIRTWNKPTSQGKLFSFTLIDESAAIRATVFNDAVDTFEPLVVNGQVYYFSGGQVKNANRRFSNVNNDYELTFDRASEVILARQDSSAAALPMQRYNFVPIELLKQREVGSLVDVLGVVLKVDEISSITQKSTGRELIKRNVKIGDMSAAVEVTFWNDEAKAWNYPVGTVVALRQLKVGSFDGVTLSSTYQTKIDVNPADLPDVKKLATWYVSTGGANVVSLSSQGLGAGGGGGGEGNRGRKYLDEIQSEGIGRGAKPEYVDVRCVPIYFKQDAQWYDACPTCNKKVTEEGAQGDRFRCEKCDATVVPTQRYLVSIQVTDNVSQVWLTLFNEAGVEFFGMEASELKRRAQEDPLYIAKLAQARMNRPVVMRLRVKEETNANAMTGEESDRLRMSVVRISEFMPVAGTTEETRRRLAQNLRSECDDILRCIEAYV
The following text describes a protein:
Function:
Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes.
Sequence:
MRLFLLVALYLSPVYGDYTDEWIDPSDMLNYDAASGKMKNKPQVESTQSYYSVENTVSQDATQQPAQKANELHQNPDMTCSAEYQEYKTKLENLKGQLEETKRMEKSKSKSQAIFKRYLNKILIEAGRIGLPDESYPKAHYDAEVVFTMEMLQEIQSFLNNGDWNVGALDDALSSTLVQFKHHNEEEWKWKFEDSFGVDVYTLFMLILCVLCLVKLIATEIWTHIGWFTQLKRLLILSTVISFGWNWMYLYKVAFAERQAELAKLQDFDKCSQKISWSESLFDWMKGAATFQNDPCEDYFKALIVSPTLMVPPTKALALTFTNFITEPLKHIGKGIGEFLNALLSEIPLFFQVPVLIFIAVLLLAFFYGAGTAVMNPVNLYRRLTGPEREKPLPVEPTRSNRKRFIEDVRVPPALGQLPRDNDVVNIPKQQPLDDIDGSNNPPVTAPADPSDTGQVKSNNTGEPLVQEDHSIKKSIKESRNDERPNTESPEAKPQRPEEPVVETLRST
The following text describes a protein:
Function:
Activates ald expression in response to alanine availability and is important for normal sporulation in B.subtilis.
Sequence:
MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPITIEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVKQIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQIRKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIEQQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIEDVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEKRKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLKRISQIAEIDLKNVNQKFTIYLDIKLRHMDL
The following text describes a protein:
Function:
Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor.
Miscellaneous:
MISCELLANEOUS: HprSR and CusSR form a unique regulation system, where both two-component systems recognize and regulate the same set of genes, but under different environmental conditions. HprSR plays a role in H(2)O(2) response regulation, while CusSR plays a role in Cu(2+) response regulation. Under low protein concentrations, the two regulators recognize and transcribe both hiuH and cusC promoters, albeit at different efficiency, apparently in a collaborative fashion.
Subcellular Localization:
Cytoplasm.
Sequence:
MKILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAKQTPVICLTARDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNSTLEISGLRMDSVSHSVSRDNISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDDPFPEKLIATIRGMGYSFVAVKK
The following text describes a protein:
Function:
Probable serine/threonine protein kinase.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Found in the cytoplasm during interphase. Localizes to the mitotic spindle in dividing cells.
Sequence:
MFWHLLCVPNDENASAPDDGNQSCQPSSKQDQYLSPNRNCQKNLLRLYPPPPSKPPPLVGAILQTRLLHQISPSAIADADADLNAVGELLYPNVLQRSATLPAKHNRLGVRSRVTFKVPSSNLPAQDSYSHQPRNQVAVAAKDGILVDVKAKESVKMTSEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKSDYMHGNITQMTVAASNASGTEYIRKRAEIETAHITATDPLNIKEKVDKNCNATSLAQPAKGSGEPMVQHGNAANNQNITSKGLQQQSTLTNSQVAIANIQSAPSMIEREDVQYTKLEEGAPTKFITMKPNGECDNVDIAAKCIFEQKHVEANDDIVGRASLSGVEQHYKSQIKKHNSPEIANKQIQRTGTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPMSVHDLPSGGGHSHQVSDLSGKQDPYAATSNAAPIGINSSSTKFGSQHGQIFGLAAMPPINRRSATSTNLRPSSSASQRINSGSTIGGAVGNGSNTARSSVAGDHSVTQFALIDDENVSALQQVTKGGALTLASQWKSQFDDSEDTTDNEWNREHQLQPNLEQLIKLDISLPLNEAKPFPQHGVAGTGKLINPPGEAKGRPKRYTLNITGIENYEALRISIPNCWSEPAMGNVLRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARPSTSSVLRNRLPSPFKKDSALQLNSTNDSLDKSRHRNSLPNVSVNDIFDDLQMKLNLDLGSAIQENNCCISGRLEIRVIPKDTSHPDDSVYYDAMGAVKNTPTANEGHDHSDQAVNNCDEMEATSAVIAFPNKSISKIMSPPGRDATEERTGASLCSLYSAGVNKLKLNGNTAPRTQFKKGSTDGFGENESEFDFPLLNPSKIPVRQSKCASWAGADFISASKPLESAEVPQEIPYHPQSDTTYSVIDSIPVRKTTYSIALECPPNISDLTPGLSYFYCNIVVPLRLFSILLTES
The following text describes a protein:
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP).
Subcellular Localization:
Cell membrane; Single-pass type IV membrane protein.
Sequence:
MPRDRLKELQEKATVNTIHAYNYDPPARKYDVESQPLINQDADFEMFLERCSNIRGGLKSLEEDYDAVVQLHGALLSTPGADSENSNKLKSHNQMFFSKAEQIKNSLKILSEETSRIPTTACGIMRAKSDQVKSIYKTFENIMLNFNREQDEYKEKAKRKIVDYLKIRNMQLSDEEIENAVSSGNLSEVTKGVMLALNEKKALYDEVKSRADELKNLERQMGELAQMFHDLHIMVVSQAKMVDSIVNSVENATEYAKQARGNVEEARNLQKRARKMKVCIIIGSIIAVLILILFIQSAVCHFTPIC