lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (By similarity). Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MARSEARRQAREKRPRAVPEERALRERRQPRPRREPLESGAGDHRRPPQASAGAAGHASFMRRLVDQEDAGGQSQEPEVLGRTGNLPRKPASRNSPEAPPLDGTLGCWATGAGAAGGFGGAQNRACVAPTSCPGNLPARPLPFLPPLLASRNPCPWHYVHLSGSHDTLVPTCFEAKLHQKGSGPTPSATSTLAERASPAMATYTYTSRPRALPCQRRRYRDDLMQQPEEPVHYGNIMYDRRVIRGNTYALQSVPLPGQPDPVEIQRQQQARRRAFARKQAQEQLRPRTPEPVEGRKHVDVQTELYLEEIADRIVEVDMECQTDAFLDKPPTPLFIPAKTGKDVATEILEGELFDFDLEVKPMLEVLVGKTIEQSLLEVMEEEELANLRASQYAYEELRNIELAEVQRLEEQERRHREEKERRKQQQWQVVHKHNETSQKIAARAFAQRYLADLLPSVFDSLRDGGYFYDPVERDIEIGFLPWLMNEVDKTMESSMVGRTVLDMLIREVVERRLNLYEQKEGRHASVRPENGLGGPGGTREPLVGFESQDQGASQAQRPLPDRDSLQRTPYDARYAERVSSQERRLAEENDELTEMRKSSKREELSQ
The following text describes a protein:
Function:
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MARSHKVTKPKRQQVDTSGSYNALMVLMGDNVKKAEKRVEEEEPVEQELEEDDIEGAGEEEEEVDEEQEEEEDADDAEEDAEDDSETDKYDPYKLHFEAEEAKYVSVIKSEEWKTSSEKTKIGSQPVRITYTNLEDADELLDFSEAQKTEFSKYTVRPRIKDGFKQLNGSLTSVQKAIYPSLMAYRDLCYATSSLSDTEEFSRLVAMHIAQHVVRTAEEVAYNTRILKRNAEEGIHDVEFRDQGYTKPRVLVLVPTKNACFEFMQLLVGASGVDREDNKARFNKAFHEAGAVLDTKPEDFQKAFKGNTDDMFCLGVKLRNKSIRYYSYFYQADIVFASPLGLKTLVGSEGDSKREFDFLSSIEIAYLHETNHMEMQSWDNVLTVLGQTNLLPNESHGCDFSRVKSFYLDGLAKHFRQTIVACQFVTPTINSVFSNTVNFAGKTKITPIYNGELAVAGMKIRQIFTRFKALSVSDEIDARFKAFVQITLEGMIRSGDYSGTLIYVPTYVELVRLRNYMDEKNISFGAISEYSSITEVKRHRTLFRDGREKILLYTGRLHHYRRYFVKGVKSVVIYKLPENPAFYRELLLFLTHSVDEGTLEQSMAKCRALFTIYDLLALERIVGTKRVKTMAKSGESSYEFY
The following text describes a protein:
Function:
Required for proper slug migration, spore differentiation and stalk differentiation (under nonbuffered conditions). Could be involved in late events of spore maturation necessary for spore stability.
Subcellular Localization:
Nucleus.
Sequence:
MSLSTVSNHIINPLGNVVYGNPSSPTSTSSSSSLTPTSTNEEMIKKEDSGTSEPSSPSTGECNGKKAGRRKIKIEFIDDKSRRHITFSKRKAGIMKKAYELSTLTGTQVLLLVASETGHVYTFATAKLQPLITRPEGKNLIQSCLNTPDNPNSPSMANQNSNNNSNLLQQQQQQQLQQQQQLQQQQQQQQQQQQQQQQQQQQQQAAQQAVQQQQQQQAAQQQAAQQQQLQLQQQQQQQQQQQQQQQQQQQQQQLQQLQQQQLLQQQQHQQIQQHQQQQQYINSNGYPETIYDIQDKDIERRLGKDNNNNNNNNNNNINNNNNNNNSNNNSGNNNSNNNNNNNNKNNSNNNSQYIQQQNLNIDLNYSNPNVYPIGNYFQQTVQSRYIQSSSSASSSPASPNQFNYSNHSMPLNNQFPPC
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MSKYVKELVTRDLKRRLEGVEDAVLVNCTGMDANTTNELRGELGQKDIQMMVVKNSLARRATEGTSLFPAFEGTNGQVAVLWGSSDFVSLVKEAVRLDKDKEKFEQFVTTGGVLDGEKLDPEGVKAVSKWPSREEQISMLVGQILGPGATLSAAMLGPGKTLNSQIKSKGEGDE
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MFSSSIRFPISIPLHFRMKTLFISALLSIAVAQKVQFLRGRAILFRSRTGDLPGEVVGVVDFYQENAGVRLNGSINGLTAGLHGFHVHDKGDLSNGCLAAGGHYNPFNKNHGAQNATIRHHGDLGNIETPNSGPTNIQCRDSYLTLNGPMSIVGRALVVHEKADDLGLGGTEASRTTGDAGARWACGIIAIMEEDPTARDNSALSFFSLSSSLLIILAYFNQ
The following text describes a protein:
Function:
DNA-dependent helicase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability (By similarity). Involved in the repair of DNA double-strand breaks by homologous recombination (By similarity). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease.
Subcellular Localization:
Nucleus.
Domain:
4Fe-4S iron-sulfur-binding is required for helicase activity.
Sequence:
MSSVLSEYTIGGVKILFPCRAYPSQLAMMNSIMRGLNCKQHCLLESPTGSGKSLALLCSALAWQQSLYGKQLVDEKSDEKEWKKMERVTPCCCSCHLKNSDQTTFSSDRQMNSTDNAPSNISGASSNKTTLASKLCAKKQASFTTDQDDDFQTDRKRIRQSHDEQLQARKRRCYEKGVQFIDDDDDDDRDHVKFDSYNQRRASMDSCAEEAIAASSNHSAGPCSLCFCGQTKEEDKATEKCKKENGEKPKVPKIFFGTRTHKQIAQITRELRRTAYSSVRMTILSSREHTCVHPDIHSNRNERCKELLEAKDGHSCRFYHGVHKMNEQSLLQYRHGIDKAWDIEELVGLGKRLRACAYFAARELMQGADIVFCPYNYLLDSQIRESMEICLENQVVILDEAHNIEDCARESASFSCSDEQLMYARDEIDSMVNHGIRVSDHEPLRAVCYSLTNWIRQCSDQLVEREYEASCKVWNGKEILSIFHDMGITNATFPLLKVNLAAVVEKEEKITMFHGQENVIKIPTLSPQSQMVLKGLFLVLDYLFRQNNRFAEDYRVALQQSYTWTNRPDIPDENGFFARPRSRRSIRQKIMVYTLNFWCLNPAVAFSDLSSNARTIVLTSGTLSPMGSFSSELGVKFSIQLEANHVIHKSQVWVGTVGAGPKGRKLCATFQHTETFDFQDEIGALLLSVCQTVSHGILCFLPSYKMLEKLKDRWMHTGLWENLERIKTVIKEPQGGDKTDFDKLLQMYYDAIRYKGEKDGALLIAVCRGKVSEGLDFSDNNARAVVTVGIPFPNIKDLQVELKRKYNDQHAKNRGLLPGSQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFRSNPKYITGLSKWVRQLVQHHSTFNGALESLTEFSKNQQQRMQMSSTNCDDEPSQGTSSSSKNTSPTSSLLEFTVHPTQSVSEFTQPTSSTQSSVTSPPEIAIPFSPIQASLGGTAPRDNAEVLSHWKEEQRRKSNTSIKTNLMKSFEKSKSNYSKQRTSFYNYFKSNAHTSTPRQSSSKTRESNLEICCNELASGYSASANSGSLSQGFGRENNVSRKQDEGLNESCQEILCNAVPLFHCTNKETHASVSPPRKYVEPSVSMLPEDNTDTDITIHCTPELYDDDGQENLVSDEEDKCNEEKENKIDSGRADKDTNACALDTSVKRENLFHKEEYLNVSGNENAFNIGRNKGTEQKNRENRLSRSRNKGVSSFFLD
The following text describes a protein:
Function:
A flexible structure which links the flagellar filament to the drive apparatus in the basal body. Absence of the gene leads to absence of the hook protein, lack of the flagellar filament and thus loss of mobility. Approximately wild-type levels of the flagellar subunits are still produced and accumulate mostly in the cytosol.
Miscellaneous:
MISCELLANEOUS: The N-terminal amino acid sequence was from strain CCUG 951; the DNA sequence was from strain CCUG 17874. Disruption and subcellular localization experiments were performed for both strains. The apparent pI for the hook protein was 5.1.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MLRSLWSGVNGMQAHQIALDIESNNIANVNTTGFKYSRASFVDMLSQVKLIATAPYKNGLAGQNDFSVGLGVGVDATTKIFSQGNIQNTDVKTDLAIQGDGFFIISPDRGITRNFTRDGEFLFDSQGSLVTTGGLVVQGWVRNGSDTGNKGSDTDALKVDNTGPLENIRIDPGMVMPARASNRISMRANLNAGRHADQTAAIFALDSSAKTPSDGINPVYDSGTNLAQVAEDMGSLCNEDGDALLLNENQGIWVSYKSAKMVKDILPSAENSTLELNGVKISFTNDSAVSRTSSLVAAKNAINAVKSQTGIEAYLDGKQLRLENTNELDGDEKLKNIVVTQAGTGAFANFLDGDKDVTAFKYSYTHSISPNADIGQFRTTEDLRALIQHDANIVKDPSLADNYQDSAASIGVSVNQYGMFEINNKDNKNVIKENLNIFVSGYSSDSVTNNVLFKNAMKGLNTASLIEGGASASSSKFTHATHATSIDVIDSLGTKHAMRIEFYRSGGAEWNFRVIVPEPGELVGGSAARPNVFEGGRLHFNNDGSLAGMNPPLLQFDPKNGADAPQRINLAFGSSGSFDGLTSVDKISETYAIEQNGYQAGDLMDVRFDSDGVLLGAFSNGRTLALAQVALANFANDAGLQALGGNVFSQTGNSGQALIGAANTGRRGSISGSKLESSNVDLSRSLTNLIVVQRGFQANSKAVTTSDQILNTLLNLKQ
The following text describes a protein:
Function:
N-glycosylase that inhibits protein synthesis in the host by depurinating ribosomal rRNA, and thus acts as a ribosomal inactivating protein (RIP). Promotes vascular permeability in the host and induces necrosis and apoptosis of host alveolar epithelial cells.
Subcellular Localization:
Secreted.
Sequence:
MYFEEGRLFFIKSQFNGRVLDVEDGSTEDDANIIVYTQKYEDCLNQLWRYENGYFINAKSAKVLDIRGGEMQPESQIIQYAQKMVEEAANQRWAIDEDGYIFCEARPDLVLDIQGAEDEDCVPVILYERREGEVSANQRWELVPFEG
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MAENGEQKGDFEAQHEAATPGKTESVGGNSAPGTPGSRRSGTNDATRRFDSDDDDVTKPCDEVKVPIDESGMDNVELDSVKEVKLEQPKSKSKKQKKEKKEKKPDTTDYVNRDPRNLQESVKVNFADIIAEPSGAHSFNTVWGTSYKVYSVTKYWVYRIMTLVFGVPCALIWGVYFACLAFLSIWWIMPCIRCLGIKINFIGKIWSLTVRTILDPVFESIGLLLSRIRIVMSLRRD
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MEDFYWSSQVSSPSSHISGAEYDEIPWRLANDQRPRLKPRRFDRRQGGERKIGKRSGDFDRRRKTHKKCLRRELAAWTPNAKRFPSNWRRNARQPSSWSASGKSWRSRSRNYAGTGRCWSGCTIENSECTFLMDNEAVYDICKRKLDIPRPGYNNLNRLNAWVGSSLTTSLHFNSDLNIDLNEFQTNLVPFPCIYYPLILYTPVISSSCSTYKSFKVKDLTLQCMYPVFSSKISLQSNHLAGFEPRNQMVVYNPQTGKYIAVALLYQGDMMPHNYARAVTDIKAKASFNLVKWCPTGFKLGINNQKPIFVPNSKLTSINCSVTILSNSTAIAEAWSCLGHKFDLMYSKHAFIY
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLLPVFLFLALFLSAKQATSDVGPADNGAVFRQLCKLVALAEKSPALGPHATLNTAAVTEMEELNISLSPATWQAKFAKAEVTDTLEEMKTKANVTDDNIAKDWHNKWRQWVLAYKATRPDTAAATRIKEAGFNNLTPGRRWAAQMRVQAHLARAQALLTEGKQYSAAAAKPTAADYPKKLKDAVLGDDVGNKASVTIAKTFSGGANSGRSNACGGNIANHPATTAAATLMCVCAEAAANQPGGACISGQTVTTTWTTAAPPALGVWTQLAGECPDDDGAVISADALLTPIRELNSMVVKLNNAGFLGKTVTKSNCDGSSDAGVCVKYSDFTGKGDKKFTDIPWVVKLVNLAQDLQLREAAAAAIKNINHQLKAEREAAYACATALTEPPTTVETKSLSSKTKEDKEGCKQQKSNKTACTEANCKWQGKTETDGPCKPKDGEGQTNAAAGTGTGTAGDQKKERAASAWCAKHGTDETACENDKTGDKQNCAFRKGKESEDEPEKEKHSLCSFIVNNKLALIAAAFFSLEAFQNCKDF
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MGTSSEDVLLMVGNVRYKKNNGTLYLMAERIAWMLEGKDTFPVSHKYADVKMQKISPEGKAKVQLQVVLHGAEGSATTFHFVNPLGTRAQLDDRNSVKELLQQLLPKFKRTLNSDLEEKNRMLQEDPRLFELYRSLVVSRVVTPEEFWANHAPVSDANGDCSLWPAQPVGVSAAFLVDVQPQTDGSEGLKYNLTADIIDSVFRTYPAGTWRKHLENVPERMTEAEFWTRFFQSHYFHRDRLHTATRDLFSDCARSDDQDVREALAAGLGDPLVDISSFQDVNSSSPCPVGVQGRESPNWQGAAGATANQSMIRRFNHHSMMVLRACGREGAPGCAADPAAKKVGPLLARRCQCPCRHLSAPARLWDRARLEDLEGVTSSTGGATVRLGHGERHQRGPTPGSNGPPCDGQVSAQALRRQLAQWIPSGRSMLPASAALSVLGELSPGGSLMKNAQQMPLKGNVELQRDLRRIYVAQYELLRHFWTCFPTTSAQLEDKVVSMRATLERFQYAQLQPFRDRLLREHHCPDLADHLDDLLQAAYAKYSSWQSRRLSLGRK
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MAVQVKFEQVGTYFKQHDKKAIPGKLPNRLNDDPDLYGKLKYPLALSLGCKDFKDEGGGDVYESIFDFTRKTANRGTSLKETIDADIFSNRSNLTTIATASKFNREPSEIIALRKNGVIFLYKNEKSYEGKYGGGYNFEKYMTLNEVGHPHNPNEKVSNATCSKVVLRTSFVSRKETIKVYYASEVDAVDKNGNFVEMKSTKSDHGKWLHWNSQKHYFQSFLGNVPTILIGRKDQNDCVYQVDKIKTSEIPKMDVKWKVQNCLAQLFTVLNKIMSKLPDDDQAISVKIADGEISYENAKAEDWNFIHPSFLEYFER
The following text describes a protein:
Function:
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.
Subcellular Localization:
Nucleus.
Sequence:
MMSEQQRDVPLEVDDKCSESDEVIESLPSCHPGALTPEKLREAEMASTGSEASDSQMPGGTSGRTSPASSTGQNSDASMSTDGDMIITDSMRAEEEKLKQNAEEEQKSQEIESGDSWKTELEEQRYKRLQHLLQKSSIYTNFLLSKMDEQQAKERKRQERQAQKRKEEEKNQKKEKKAEEKKEQLETPKRSRRSARKQDQEDSQESGSSQEGAGKKSSKGKKQNSETDSPGRGRKRKADTYSIADYLNKETLTKTSKKQNVDQTDTAAEPTDTLTVDDDADQTVKASKGDFVDTFSRVINGEKVSDLQPDLFSGGVLRKYQLDGMEWLKVLYENGVNGILGDEMGLGKTIQCIALFAYVIEMGVPGPFLVCAPLSTVPNWVSEFQRFTPKIPVLLYHGTKEERAKKRKQIRKKIGEHQSHPIVITSYEIVMNDRIHLQGLQWKYVIVDEGHRIKNLNCRLIKELKMYQTANRLLLTGTPLQNNLAELWSMLNFLLPEVFDDLNTFQSWFDFSTLSKEGGDEAIIAQEREQHVISMLHQILTPFLLRRLKADVDLMIPPKKELLVHAPLTKHQEKFYKYTLDKTIKERLQEGDEPTAAPVELTPSGRPKRRSKTINYAIMMDSGKKEKEKKGKKRINFEKEEDDIIEWSNMMEKQLEKEEREMNLKMPETSVVNIKLQNVVMQLRKCCNHPYLLEYPLLETTGEYRVDEELVSSCGKMLVVDKLLPALKERGHKVLIFSQFTTMLDILEDFCHMRSHQYCRLDGTTSLEDRQERMKEFNSNPDVFLFLLSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVIIYRLVTANTIDQRIVERAAAKRKLEKMVIHQGKFKGGKSNLAKDHKALLNPKELLALLRSSDHSGEVKNCREKGISDSDLQLLLDRSDLNAEQKKRSDELAKGSKVKEAQEDVSQGAQEMQMEA
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVKKREPTSRVTSRVHKTPSPSPRAVDDSGKQKPDLSTTPPPSPGEGGNGDEVLTSSQTNATDLRDELIWSDRESDDEVFLFPDAQELVEPQGGPDCDVIRIGATQKLDESDSSEDEATLNRVGDIPLEWYKDEAHYGYDVEGRKLMKSERSALERLLEATDDPNAMRTIYDALHDEKKVLSNADLQMIFNLQRNRTPNPNYNMYEDVAVDTVEFDPLNHPLARSAGPSKRKFLPSDRDMKTIAKMVRRMMKEDKEKENKPKDETESETTILWDDGKVVMDTHTHFKYHNRVPKPKAAPPGTYESYRPPPEYLPSERAKERFARLRAIDKKEHFLPRAFDALRHVPFYNHTIQDRYQRCLDLAFFPRAQRTRLVVDPSKLLPELPDPRDLRPYPERLSFQYKGHTATVRSVAVNPNGQYLATACDDHLVRVYEVMTGRLMKRYDMGAPVQQVEFCPVKTLNILAVAVEYSLVFIVPRFAAHELVNENTLRHLRAPGTAVNNTEVEQVVGGEVSLGGGGITQAALDKDETAHSILQDLHDVEERDKRAEFFDASAKERRAGIVLKIALHAKVKRFTFHARGDYLCALCPKDHVKYRQTVMLQLSKRKVFCPFRKFSEVVTDCKFHPREPLFFLSTTNSVRMYNLLAHKLQRRYKAPGGITTCLSIHTEGDNFLVGDTTSHTQWYDCDFSDKPYKRMRSHKGVVNAVAFHTNTNAYPLFASGAADGQVHVFHGMVYDDYNKNALLVPVKILKHRRAVYSVAWHPTLPWIFTSTEDGVVSAWTE
The following text describes a protein:
Function:
Endo-inulinase involved in utilization of the plant storage polymer inulin, consisting of fructooligosaccharides with a degree of polymerization (DP) value from 2 to 60.
Subcellular Localization:
Secreted.
Sequence:
MLNPKVAYMVWMTCLGLTLPSQAQSNDYRPSYHFTPDQYWMNEPNGLIKIGSTWHLFFQHNPTANVWGNICWGHATSTDLMHWAHKPTAIADENGVEAFTGTAYYDPNNASGLGDSANPPYLAWFTGYTVSSQTQDQRLAFSVDNGATWTKFQGNPIISTSQEAPHDITGGLESRDPKVFFHRQSGNWIMVLAHGGQDKLSFWTSADTINWTWQSDLKSTSINGLSSDITGWEVPDMFELPVEGTEETTWVVMMTPAEGSPAGGNGVLAITGSFDGKSFTADPVDASTMWLNNGRDFDGALSWVNVPASDGRRIIAAVMNSYGSNPPTTTWKGMLSFPRTLSLKKVGTQQHFVQQPITELDTISTSLQTLENQTITPGQTLLSSIRGTALDVRVAFYPDAGSVLSLAVRKGASEQTVIKYTQSDATLSVDRTESGDTSYDPAASGVHTAKLEEDDTGLVSIRVLVDTCSVEVFGGQGEAVISDLIFPSDSSDGLALEVTGGNAVLQSVDVRSVSLE
The following text describes a protein:
Function:
Acts as a DNA polymerase processivity factor; a transcriptional activator for several EBV promoters and inhibits the host DNA damage response (DDR) to double-stranded DNA breaks. Plays an essential role in the viral lytic DNA replication by acting as a polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template. In addition, BMRF1 transcriptionally activates the oriLyt early BHLF1 promoter. Promotes G1/S cell cycle arrest through p53 induction.
Subcellular Localization:
Virion tegument. Host nucleus. Note=BMRF1 shows homogeneous, not dot-like, distribution in the replication compartments, which coincides with the newly synthesized viral DNA.
Domain:
The N-terminus is important for dimerization, DNA binding, and DNA polymerase processivity. The C-terminus mediates transcriptional activation.
Sequence:
METTQTLRFKTKALAVLSKCYDHAQTHLKGGVLQVNLLSVNYGGPRLAAVANAGTAGLISFEVSPDAVAEWQNHQSPEEAPAAVSFRNLAYGRTCVLGKELFGSAVEQASLQFYKRPQGGSRPEFVKLTMEYDDKVSKSHHTCALMPYMPPASDRLRNEQMIGQVLLMPKTASSLQKWARQQGSGGVKVTLNPDLYVTTYTSGEACLTLDYKPLSVGPYEAFTGPVAKAQDVGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVVAGLLTSAGDLPLDLSVILFNHASEEAAASTASEPEDKSPRVQPLGTGLQQRPRHTVSPSPSPPPPPRTPTWESPARPETPSPAIPSHSSNTALERPLAVQLARKRTSSEARQKQKHPKKVKQAFNPLI
The following text describes a protein:
Function:
Catalyzes triacylglycerol (TAG) formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol (DAG), thus forming an sn-1-lysophospholipid. Plays a major role in triacylglycerol formation at log phase. Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MASSKKSKTHKKKKEVKSPIDLPNSKKPTRALSEQPSASETQSVSNKSRKSKFGKRLNFILGAILGICGAFFFAVGDDNAVFDPATLDKFGNMLGSSDLFDDIKGYLSYNVFKDAPFTTDKPSQSPSGNEVQVGLDMYNEGYRSDHPVIMVPGVISSGLESWSFNNCSIPYFRKRLWGSWSMLKAMFLDKQCWLEHLMLDKKTGLDPKGIKLRAAQGFEAADFFITGYWIWSKVIENLAAIGYEPNNMLSASYDWRLSYANLEERDKYFSKLKMFIEYSNIVHKKKVVLISHSMGSQVTYYFFKWVEAEGYGNGGPTWVNDHIEAFINISGSLIGAPKTVAALLSGEMKDTAQLNQFSVYGLEKFFSRSERAMMVRTMGGVSSMLPKGGDVVWGNASWAPDDLNQTNFSNGAIIRYREDIDKDHDEFDIDDALQFLKNVTDDDFKVMLAKNYSHGLAWTEKEVLKNNEMPSKWINPLETSLPYAPDMKIYCVHGVGKPTERGYYYTNNPEGQPVIDSSVNDGTKVENGIVMDDGDGTLPILALGLVCNKVWQTKRFNPANTSITNYEIKHEPAAFDLRGGPRSAEHVDILGHSELNEIILKVSSGHGDSVPNRYISDIQEIINEINLDKPRN
The following text describes a protein:
Function:
Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting.
Subcellular Localization:
Early endosome.
Sequence:
MVDFLAENNLCGQAILRIVSRGNAIIAELLRLSDFIPAVFRLRDKTDQQKYGDIICDFSYFKGPEYYEGKLEAKPELQDLDEEFRENNIEILTRFYLAFESVHKYVVDLIRCLDDLNEGVYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKMEGEVRERMLVSYYRYSAARSSADSNLDDICKLLRSTGYSSHPGAKRPTNYPESYFQRVPISSTFISMVIGRLRSDDIYNQVSAYPLPEHRSTALATQAAMLYVCLYFTPSILHTQQAKMREIVDKYFPDNWVISIYMGITVNLVEAWEPYKAAKIALNYTLDTANIREQAGRYAASVETLRPQVQQLLKEGFLREEIILDNIPKLLNCLRDCNVAIRWLMLHTAESAYDPNNKRLRQIKDQVINDSKYNPKILFQLLLDTAQFEFILKEMFKQMLAEKQLKWESYKKEGSERMMELAEVFSGVKPLTRVEKNENLQAWFREISKQIESLNYEDSTAAGRKTVQLIQALVEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSYAWQIIDSFTAIMQESIRANPSMVTKLRATLLKLASALDLPLLRINQVNSPDLLSVSQFYSGELVAYVRKVLQIIPESMFTSLAKIIKLQIHDIMEVPTRLDKDKLKDYSQLSARYEVAKLTHAISVFTEGILMMKTTLVGIIQVDPKQLLEDGIRKELVKRVAYALHKGLIFNPKAKPSELMPKLKEMAATMDGFYRSFEYIQDYVSIYGLKIWQEEVSRIINYNVEQECNSFLRTKIQDWQSVHQSTHIPIPKYPSVDESATFIGRLCREILRITDPKVTCYIDQLNTWYDLRTHQEVTNNRLFSEIQDTLGTFGLNGLDRLLCFMIVKELQNFLTVLQKSILKDKAVVDVFKALLTAVNPVKGIVANASKVYTNAAAKTQKIWSPYLESIMKVGQMQILRQQIANELNYSCKFDSKHLAAALDNLNKSLLSDIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKSQGMACRKPADALDWAPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSIMEQCTSQKIPDMPSDVVGALMFLEDYVRYTKLPRKVAEAHVPSFIFDEFRTVL
The following text describes a protein:
Function:
mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSSEVASHYNKVLQVGIEGRKESRIFFMRNMNNWVKSQLINDAKQRVNDNGVNNPRVLDLACGKGGDLKKWDIAGAKDVVMADVADVSIQQAEERYKQMFGYKKNNIFTVQFIVADCTKENLEDRIENKDPFDLVSCQFALHYSFVDEASARIFLKNAVGMLKPGGVFIGTLPDADRIVWSMRNGENGQFANEVCKITYENVEELAEGKVPLFGAKFHFSLDEQVNCPEFLAYFPLVKHLLEELDMELLFVHNFAEAINKWLEPGRRLLESMTGLETYPNEKLSGKSDDEYLEAKAKLDAFPEDERIKTMGTLSKSEWEAICMYLVFGFRKKKSEAEKTEEEPATTKPVAESESEQKEVTESEEKEDQEDCEHQEAQTN
The following text describes a protein:
Function:
Terminates the cell cycle delay. Reverses the CDC28 phosphorylation catalyzed by SWE1.
Sequence:
MNNIFHGTEDECANEDVLSFQKISLKSPFGKKKNIFRNVQTFFKSKSKHSNVDDDLINKENLAFDKSPLLTNHRSKEIDGPSPNIKQLGHRDELDENENENDDIVLSMHFASQTLQSPTRNSSRRSLTNNRDNDLLSRIKYPGSPQRSSSFSRSRSLSRKPSMNSSSNSSRRVQRQDGKIPRSSRKSSQKFSNITQNTLNFTSASSSPLAPNSVGVKCFESCLAKTQIPYYYDDRNSNDFFPRISPETLKNILQNNMCESFYNSCRIIDCRFEYEYTGGHIINSVNIHSRDELEYEFIHKVLHSDTSNNNTLPTLLIIHCEFSSHRGPSLASHLRNCDRIINQDHYPKLFYPDILILDGGYKAVFDNFPELCYPRQYVGMNSQENLLNCEQEMDKFRRESKRFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSALSFRFEPPPKLSLNHRRVSSGSSLNSSESTGDENFFPILSKSSMSSNSNLSTSHMLLMDGLDTPSYFSFEDERGNHQQVSGDEEQDGDFTFVGSDREDLPRPARRSLFPSLETEDKK
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MGDTSEDASIHRLEGTDLDCQVGGLICKSKSAASEQHVFKAPAPRPSLLGLDLLASLKRREREEKDDGEDKKKSKVSSYKDWEESKDDQKDAEEEGGDQAGQNIRKDRHYRSARVETPSHPGGVSEEFWERSRQRERERREHGVYASSKEEKDWKKEKSRDRDYDRKRDRDERDRSRHSSRSERDGGSERSSRRNEPESPRHRPKDAATPSRSTWEEEDSGYGSSRRSQWESPSPTPSYRDSERSHRLSTRDRDRSVRGKYSDDTPLPTPSYKYNEWADDRRHLGSTPRLSRGRGRREEGEEGISFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVRRREQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERKKAQHKHWELAGTKLGDIMGVKKEEEPDKAVTEDGKVDYRTEQKFADHMKRKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAPGDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAELGPMFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSVRSTKIYTPGRKEQGEPMTPRRTPARFGL
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Is involved in resistance to the arginine analog canavanine (CAN).
Sequence:
MGKRAERKSRAAAAKQKQAAARAPKSVLQQSKPVESTDDGVPVMKERKPCPHLDKGIDSDKISVKIGSSDPIRCEDCREGVGDRRGKKGKGKHGKKKGSSLVDSKAIWVCLGCGHYACGGVGLPTTPQSHVVRHARQTRHPLVIQWENPHLRWCFPCNTLIPVEKTEENGENKDALSEVVKLIKGRSTEISSVDVEDAWFGSGNVNSEIKSESTVVSGSDLDGNACYVVRGLANLGNTCFFNSVMQNLLAMSQLQDYFLNAELTFGPLTIALKKLFAETKPETGLRNVINPRSFFGCICSKAPQFKGYQQHDSHELLRCLLDGLCSEELAFRKRNSPSEGNGISSNQGPVFVDYVFGGQIASTVRCVECGHSSTVYEPFLDLSLPVPTKKAPSKKTQPASRAKKTKLPPKKSGRIRAKGTKDTHAVTTQSISNLSISSKSQSLTESTAPLSENVVSSSGGSQLLDSVGSPTVATQCGSALQNVPADPLPQHDQVIDIPVEQTVASLDDFWLDYIEPQTTGDVLDSTWQKSDVSVIQDSTDFAWLDYIEPETISDEHGLTLENNDVLFVQDSGEQDEVSDDSLINSNQIPLLDSKPNLKADSSSGDAGEDELPLVVQDSEVILLPYNEEISTTAEKISGEGEASSSVVGCRQEEVDFDGFGDLFNEPETAIGPVPRPSSGTESVGSGFVVGNSSDSDPDEVDDSDSPVSVESCLVHFIKPELLTDDNAWDCESCSKTLQRQKLEALKRRAKLASKPLINGGETSNQNDIQGSSLTDVDSLCNGDAKTNNDLNTFCESLVSQSGKTDCFNQDCAEVESGLTNDVNPAVPQREKGKMKINDAVEMQSRSSCLRDSCSQESITDQDEGSCSVDGATSSGYSAEKVYQSDSQLVAGNCESEESKVEEINSKIVKVKRDATKRVLINKAPPILTIHLKRFSQDARGRLSKLNGHVNFSEIINLRPYMDPG
The following text describes a protein:
Function:
Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (By similarity). Transcription repressor that regulates organ growth. Binds to the promoters of G2/M-specific genes and to E2F target genes to prevent their expression in post-mitotic cells and to restrict the time window of their expression in proliferating cells.
Subcellular Localization:
Nucleus.
Sequence:
MSSTFNPAASSPDEEETGEVKIEDQCVENKQSTPASCSSVSEGSAGSSHKSPTIASPATVSPTHRYLGRTSGPIRRAKGGWTPEEDETLRQAVDTFKGKSWKNIAKSFPDRTEVQCLHRWQKVLNPDLIKGPWTHEEDEKIVELVEKYGPAKWSIIAQSLPGRIGKQCRERWHNHLNPDINKDAWTTEEEVALMNAHRSHGNKWAEIAKVLPGRTDNAIKNHWNSSLKKKSEFYLLTGRLPPPTTTRNGVPDSVTKRSSSAQKRVFGSVAQTSSVTTDVNNLAEDGNGQINSSVPVEEVVAASRMTSLNEYARSPQLPNPEPLPENGGAANNGYHLYYTPQIDYYRASEVDTQRMYGNECGCSPSASPVSFFTPPPCRNVHSNGSTPRSPESYLREAGRTYPNTPSIFRKRRPRVVVQDNNNAKKTDEAKEVDQKVNDGKDSSEIQNNGSNAYNLSPPYRIRSKRTAVFKSRQLEFISREEEKADDETKSSEKDMLIDGDSQLLG