lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NAD-dependent histone deacetylase, which contributes to both telomeric and centromeric silencing, proper cell cycle progression, DNA damage control, recombination, and genomic maintenance.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKVEEHVPLIQESRKRKCQSSENASKRQQLLSKLPLRLHTGNENVDLSPLVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFSSLRAEYKLNCSGKELFDGSVYRDLKSVNIFHAMIRKLHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLETRLEGLQTCIPLPQSAPWPTTIPLHGTLEVVSCTRCSFLKKFNPDIFDRNGVTVCPDCKTENEVRRIAGKRSVIEGCLRPRIVLYNEIHPDSESIGSVCSQDLKSRPDCLIVAGTSCKIPGVKRIIKEMSNCVHKQKGNVIWLNYDEPTKDFLNLCDLVVQGDLQIAIRRLKPLLDAPSWKLKSHSAKRTSKQKSSEQTKITSSTKITKAIGLNTKSNDSSKKDNTSFQLHQVLNSIEIPKVEIKQEVEYATPSPL
The following text describes a protein:
Function:
Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein.
Subcellular Localization:
Cytoplasm. Note=Enriched in the periphery of the cell, excluded from the nucleoid.
Sequence:
MKSNRQARHILGLDHKISNQRKIVTEGDKSSVVNNPTGRKRPAEK
The following text describes a protein:
Function:
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Oxidizes xanthine, hypoxanthine and pterine at high rates. Can also act on purine and guanine.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDLQLHQSLGHHNFTNKLTFYVNGVKRTISNPDPRGTLLDFIRTHEGLTGTKLGCSEGGCGACTVVVASWDREQGEIIYSAVNSCIVPLVAVEGKHLITVEGIGSSNNPHPAQERIALFHGSQCGFCTPGIVMSLYALLRNTGGQPSKEQIAESFDGNLCRCTGYKPIIDAANTFSCGRPGGCCRDNASGKANGAGATVGNGMANGAAAVANGNGAAANGCCKGNGAANGCCKSNGSAATTANGDDKEVDMNKLFTPNGLPLKPYSAKTELIFPPALKKYELNPLFFGNEQKVWFRPVTKLQLLQIKHAYPESKIVGGASEIQIEIKMKAANYNISVYANDIEELKTHKYIPGKGLEFGANISLSKLEEVCDKLVHELDPNVSQIYGAILEQLKYFAGRQIRNAATPAGNIATASPISDLNPVLVAAEAVLTVESIENGEEQISMTDFFVGYRKTKLPAHGVITKIFVPETVPRNEVVMAYKQAKRKDDDIAIVTACLRLALDDDFRISKARLAYGGVGPFTTAAKGTAEFLTGKLLRRETAKEVLEGAIDCLIKEFDLPYSVPGGMAAYRRTLIMSFFYKFYSTVLEKIGLAGEAQDNSALENTYDPQALLEVTRKHPVGSRDLTNPYEQRIVGKSDPHLSALKQVTGEAVYIDDIPPYHGECFGVQVMSTKPRARILSVDPSPALEVEGVVGYVDVNDLPSREANIWGPTPVGKEPFFADGEVYYVGQCIGVIIATDRMIAEEAARLVKVEYEELETVITIEEAIEAQSFFDYQPKAEKGDVDGAFAESAYTFEGTSRIGSQEHFYLETQGSLVVPEPEDGEMKVYSSSQNPTETQVFVAQATGVPSSRIVARVKRLGGGFGGKESRCCHLSSIAAVAAKKYKRPVRMILSRSEDMLTAGQRHPFVMKWKVGLDKNYKFTALEAKLYANAGWSMDLTKGVIERAVLHAENCYDFPNARIQGIPCRTSVASNTAFRGFGGPQGMFMAECYIYEIADQLGIEPDTLREINYLVPGVSSTPFKQAITEDFTVPDMVKQIKKQSNYDDLRRQVEEFNSKHKWIKRGLAHVPTMFGISFGATFLNQAGALVHIYHDGSILLTHGGTEMGQGLHTKMAMVCAEELKVPLSQVFISETSTNTVPNTSASAASASSDLNGMAVKHACDQLNERLAPYRERLGENATMEQLAHAAYFDRVNLSANGFYKTPDIGFVWGDPNPKPAFFYFTQGCAVAMVEVNTLTGDWSNLRTDIVMDIGRPINQAIDYGQIEGAFVQGQGLFTIEESLWLRNGALFTRGPGAYKIPGFRDIPQEFNVGHLRDRPFKHLKTIHRSKGIGEPPLFLGSSVFFAIRDALSYARRQNLGEATMPAGLVAPMTTERIRMLAGDSLYEHKGKIEPTEGDDKPFFVNA
The following text describes a protein:
Function:
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Sequence:
MDRYLLLVIWGEGKFPSAASREAEHGPEVSSGEGTENQPDFTAANVYHLLKRSISASINPEDSTFPACSVGGIPGSKKWFFAVQAIYGFYQFCSSDWQEIHFDTEKDKIEDVLQTNIEECLGAVECFEEEDSNSRESLSLADLYEEAAENLHQLSDKLPAPGRAMVDIILLLSDKDPPKLKDYLPTVGALKHLREWYSAKITIAGNHCEINCQKIAEYLSANVVSLEDLRNVIDSKELWRGKIQIWERKFGFEISFPEFCLKGVTLKNFSTSNLNTDFLAKKIIPSKDKNILPKVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELGLTNSTKQNSVLLLEQISSLCSKVGALFVLPCTISNILIPPPNQLSSRKWKEYIAKKPKTISVPDVEVKGECSSYYLLLQGNGNRRCKATLIHSANQINGSFALNLIHGKMKTKTEEAKLSFPFDLLSLPHFSGEQIVQREKQLANVQVLALEECLKRRKLAKQPETVSVAELKSLLVLTRKHFLDYFDAVIPKMILRKMDKIKTFNILNDFSPVEPNSSSLMETNPLEWPERHVLQNLETFEKTKQKMRTGSLPHSSEQLLGHKEGPRDSITLLDAKELLKYFTSDGLPIGDLQPLPIQKGEKTFVLTPELSPGKLQVLPFEKASVCHYHGIEYCLDDRKALERDGGFSELQSRLIRYETQTTCTRESFPVPTVLSPLPSPVVSSDPGSVPDGEVLQNELRTEVSRLKRRSKDLNCLYPRKRLVKSESSESLLSQTTGNSNHYHHHVTSRKPQTERSLPVTCPLVPIPSCETPKLATKTSSGQKSMHESKTSRQIKESRSQKHTRILKEVVTETLKKHSITETHECFTACSQRLFEISKFYLKDLKTSRGLFEEMKKTANNNAVQVIDWVLEKTSKK
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTSLAQQLQRLAVPEARAAVTAQRKDRKSLLFDPAEAGGLDKDTFYAIGVNGLQELQGIDPRFHDLESLLFDEASKSLERSIESREINDKLDKKIRQFLLTVSPYFLLKPAQKAIEWLVYRFHIQEYNTDDLMMCVLPYHETKIFVRAVQLLNLKNKKSKWNWLERIQKPGVSLSRLSLVTHCISDRGFLHFICELPLLAIKAHKKTVLPGGSPNPPSNAPLRVMFTFYAATVVSAISSPGAIKEVFLASILPFLLRGLKLDYLDYNGATYMIVCQLGVSATLKNTLLEPLMEAMCQHVNAEMIQQMLGCLAVLCRTQNIKQLPGKVMFQICALPKVLISLAQLSKSHNITPLLAALLPHLTTTAINAEVSEEIEFPEGCKELDLIASLTGILREIHVESHIVVDTARCLLHGYVSACTDGLDDDRRRDLREKIAPVVQSLERRFPEAMDFILESYLAEVEDQDKQQYVQDFVSMYSGGMKHQLLPEANTSLVLSLNHANPDVRRMAVNHIHNLIQQGGELEPFFQESLLQRLQDDSLSVVGAVLQIDECLCELLPADPVFAALQKLLNKRKKRHGDDWGNMVKGAIKIITSQAFVSKAPHLVDDAVAMTIPHIFLTTQANSSLELELRAAIARSHLVTSHPLMKGLKSGELQLYTLLFLTP
The following text describes a protein:
Function:
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSRRIIPCLDVRDGRVVKGVKFRDHIDMGDIVELAMRYRDQGADELVFYDIGASPEGRSVDYAWVERVARLIDIPFCVAGGIRDVETARAVLHAGADKISINSPALGRPQLISELADAFGVQCVVVGIDSIREEDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQRLGAGEIVLNCMDNDGVRHGYDIAQLRQVRALCRVPLIASGGAGEMQHFADVFDQADADGALAASVFHSGAIPIPELKRFLRAQQIEVRDGQ
The following text describes a protein:
Function:
Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
METLSYTCLRKRKAESDEPVQKRVRQLPVGNHLPLSRLLQYTNKQQVHDLLLQCVHKHPDLAKDIRNSLPPPSLEECIDTLQQLLKQLTDAFPYGGDARGDYAYHRVKHAYMAVFHALNDLVPCFLPPHSSCYKTNFAFLDAATNVIHKLPEFHNANYNVYKYQAYYELSGAWIVVLRQLEDKPVIPELPIRELQEHNKKSQNRLQEALDYVTSLQKDQSVFTYDTGFGAFDWNLHRA
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MYGYGGGMMRGPIKNQGLSKMDELDYELWHACAGPLTSVPPVDSLVMYWPQGHIEQVIACTPDSAGAADVREASSHFKLPSHLLCKIGQLELQADPHTDEVFAQMDLLPQDEGSLTKEMKDATHVAKQNNVKMFCKTLTASDTSTHGGFSVPRRSAEDCLPSLDYTANPPCQELVAKDLHGHEWKFRHIYRGHPRRHLLTTGWSAFVSAKKLVAGDTVIFLRGENGQLRVGVRRASKQQPQARSTNFSSTNLHLGVLAAASHASREGMRFSVIYNPRTSPSEFVIPYNKFLKAMDNKLAVGSRFRMKFESEESSERRFAGTITEVSDADPVRWPNSLWRSMKVEWDEVISASERHERVSPWEIEPFVQISTLPPPQLGPRQKRRLPTLVKESPLGTSQSVLDSYQSNKLAKILQGFDPRNESSMEDDEDGDVACSGNTSWNVKPEPPPKGLPQAEIVQQSWFPRPDISSYGIPGDPYQPLISPRVSSVTSFAPPLAAESMDLQLSVKSARSEQAPSKDYSSAPWSDFSGICPSNRTGASFPVRESPCPSINPSWLYSASTSRAVFERSILTNSLHSESAPEMLPPQAVPAFEVRDKAQLEKVDTTPGLVQPCKLFGFNLADKIVPTLAPLPPSQGDVSEGLVDSIRTDSTSPTSGGPFGSKVAAESSQVSQAHAAPMRSGIKVYQQGKVGRTIDLRKCESYDGLRRVLANLFNLQGQLDDVTKGWQLVYTDHENDVLLVGDDPWEEFCGCVRSLKILSPQDAAGQTVGRIPASSCEEDDEWH
The following text describes a protein:
Function:
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities. May play a role in the regulation of the circadian clock.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region.
Sequence:
MAARMAPTPRSSKVVQGLTGLRNLGNTCFMNSILQCLSNTKELRDYCLQNQYLRDLNNNSRMRTALMSEFAKLIQLLWTSSPNDSVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHGEVNRVLVRPRANADTLDHLPDDEKSRQMWRRYQEREDSRVSDLFVGQLKSSLTCSECGYCSTAFDPFWDLSLPIPKKGYGEVTLMDCLRLFTKEDVLDGDEKPTCCRCKARTRCTKKFSIQKFPKILVLHLKRFSEARIRASKLTTFVNFPLKDLDLREFASQSCNHAVYNLYAVSNHSGTTMGGHYTAYCKSPISSEWHSFNDSRVTPMSSSHVRSSDAYLLFYELASPSSRM
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MQIQNVEALKTWLTSRLEPICEADPAALAKYVVALVKKDKTSEELMEVCKDQLEVFLSDETNKFVEVLFEALKDDSYIPSTISTSVPEKLRPVSVTEEAPPAKLVEVSVPDDDERDFRRTRKNTDPSNKPNRNSIPVDRRKRRADEDIRTDNHKIAKEDLNTKQNDSENASLDIDNKGRPQPIPTTREGNRDWDRDRRYPRDFSRSDDDGRTRRGPVWDRIGRGRDRDNNRTGRSRGHRDRYQEGRFSREAKNRCRDYEEKGFCIRGELCPFDHGNDPVIVGQEIPPMQNMMPFSGAPHFMPGAPPLPGIPPVMVTAPDNFHRKLGQPTPQPKNDTANRDSAKADPKQPEKEAPNSGALIPNIPPPGMQTLMGLPPTGVPPQMLPMMPPRPTVYHPPADDTYNPEQPQFDRPPVWMRVGIPGQMPPGSIPYNPDMAARSRELVTVPPDQSQITVQVTTDPPTGETSRVVIGPPGSAPDAAADQSDAVKNVPMKRKFSDTLEIKKIPRDQNNITKLNEYFKRFGNIVNIQVNAFNDPEAALVQFSNSLEARNAYRCPDAVLGNRFIRVFWHNPDQQPQQKDNSAGREPKKVFEPKKPTMFQSGKTTFVRKPSEAATTESSTVPQTVVSETKSSTTTATITTTSEVTTSAAVLTVAPAATTTASAIAPSASTTVTSTVKPVVNSKLQQQQDLMIKKLEIQKQKQELLDKQIQQQKLLISKLEKKNLSANEKSAIMKTLKLLSSNIEGLKQEVEIAAITVKSKESPQQARQIAQKAILDQELDLISHQHHGEDTTELKKKVEELKQEAKSLGLFDGPSRGRGASAHVRGRGRGARGRGRGAGARVWTRESATLDKRPKQISVANITSEQKENVVEHFMEFGNVDRVDYESKTSVLVLTFRTRKEAEIAFAKGRRLKEQMLDVSWYRPSSPTAASAASPATPTPGVRNRSSTLSSGGLDEDLALDLGTELEKHDVDHEAEEALLLEDFDEEEDEEERSWRR
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDRVNFSIDQLLEETSKLVSLGIISKQECKDIMKKREYHEIKIFNRNSHKSDFLTYIKYELELDRLFHKRGKAKNIEFDYRLRSALRHAIILFGSATKKFPKDEALWINALNIRMKRASKEGTGRLFSIALSNLPRSAKLWKLAATFEFEVNKNIQNARNLIQAGIQFNKTDKSLWHYFFLMELTYISLLFSDITFIDKKIEEEEEEAIKLNLDSLRKSEKIEKDEFITFGKEILSADKLKQSSLIRGQIAQIVFRKAIKSSIGQDFDFRKHFYKIASKFLDIGKDSENPMGAGELLQKEILESLVTDFPNDDKTYIFLASIEQSKSSEPSLLKRLNNSTKILNQGLTIIKSESYLFNYIHFIRQIIVDIKLKENKLIENITDILLKAYKYSIDNNILKESGYQYYIELLLELGKTNDAIKVSEESVKLFKNSNQLWNQRINLLIKNEMVVKLFDNLSNNNEYNNIDKCFEMAVKNCTSSTTSTTSSTSTSSSSNLFIEYFKYQVVFKFDKDYKKIVDLFEKLLKQLDEFYQKCILYEEERIEKNINDIRSLYEKCLSIKEISSKDVDVWLNYRNFELKSAGDIERANTIATRGKKSLADPLPLLSQLQ
The following text describes a protein:
Function:
Involved in the oxidative degradation of abscisic acid.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAAFILFLCLLVPLVLACAIRARKGAGGRSSSGGGKKGSSSLPLPPGSMGWPYVGETTQLYSSKNPNVFFARKRNKYGPIFKTHILGCPCVMVSSPEAAKFVLVTQAHLFKPTFPASKERMLGPQAIFFQQGDYHAHLRRLVSRAFSPEAIRGSVPAIEAIALRSLGSWEDLQVNTFQEMKTYALNVALLSIFGEEEMQYIEELKQCYLTLEKGYNSMPVNLPGTLFHKAMKARKRLGAIVAHIISARRERERGSDLLGSFMDGREALTDDQIADNAIGVIFAARDTTASVLTWMVKFLGDNPAVLKAVTEEHAEIAREKALSGEPLSWADTRRMRMTGRVIQETMRVASILSFTFREAVEDVEYQGYLIPKGWKVLPLFRNIHHNPDHFPSPEKFDPSRFEVAPKPNTFMPFGNGTHSCPGNELAKLEMLVLCHHLATKYRWSTSKSESGVQFGPFALPINGLPMTFTRKDKNKA
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
The following text describes a protein:
Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSISNGWSSSSIISDVLPEEEFEEVEEDELILNENDRLKFRVDELEKIVVAQRNEILLLQSSTVEILRRLQNLEIQDQSRSPTCSGYSSLPRRISGSKSSYTMSPSHAPPRSSHANSKSLYINGMNNNSEEVSPGPPRHRPPTRGSDGMVNVSVGKSARGSPMRKWVSTHDMKDTDRFRRLSTSSEASTSATMNPIVNSVRRLSTTHRQSSPSLLSLCSVISRSPSTSSILRKNNRTCQFSNGSGHLPIFIGGKTVQVPVPTGYENMDPTMDQDPPTMKVTLKHVYSYRGKDVRSNIEMLPTGELVFFSANLVVLMNITGEDRSQRIYHGHTCDVKCITLHPNKILVASGQSSCHSVEKFQKPEHTSPIDSPEDLVRQLEMEHTEAHVRIWDTIKLTTLMVLNGFEKGICHVAFSKTDSGSLLAVVDDSLKHLMSVWNWQKGKREGEVKASNDVVFECKWHPTIRNLIVLYGKGHFSFFNYDPATGVLVKTVATFEGRDKPKTVLSMCFGENDQVVTGDSNGTISIWDPRTCKTTKQAHSVHPGGVYSLTLAKSGKILSGGKDRMVSEWDLQDLVRTRRPIELPDEKGFPRVILQNGSELIIGTSSNTLLFGNIENSTNLTSLIEGDPGNLTFLLTCSSNQLITSSQCGTLRIWNHIDKKVEFSKKFIDSVECVDVDVTNTHIILGFAAGLWIVMNITKQQTIQEKKEGTAPITAVKFAPSGATFAVATKDPHLTIYRIDASKNLLVIARIHHIPAPIVALDFSSDSQYLRGQSIGAHLLFWTKAGEICDGTSVKDVKWGSSRVKIGFETALVAHSSNGQVTAVAQCEDISACGMENGTIRIYKNPVTSVTAGFVELLGHGRIIKSVAFSNKIQLFSCSPTDNSVFEWCLE
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Together with NdufAF4, involved in biogenesis of complex 1 modules N, Q and P-peripheral, but not the P-distal module. Required for recruitment of the complex I assembly factor Timmdc1 to complex 1 assembly intermediates.
Subcellular Localization:
Mitochondrion.
Sequence:
MIARTLRTVGRQGRNLLLPRITACRPLHAIPANFSKAYDHDGKTKVTIFNTETDLGLMVTGYSQYGFRLNNDMVLIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTLEPKIDVLIIGIGDQAPPPALSKRIIEFMKKYKINVEILRTEQACATFNFLNAENRMVACALIPPLHLSYNENDILQAKLRKKELYETE
The following text describes a protein:
Function:
Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Golgi apparatus.
Sequence:
MGLRGLLALLRAAAPSAGDEALEELKMSGAASYEQLVRQVEALRRENSHLRRELQDNSQHLSKLENETSDMKEVLKHLQGKLEQEARVMVSSGQTEVLEQLKALQMDISSLYSLKFPEVAVGVGEDSPQHSTPHGDSAGDVGRATLQLLEELDRERCFLLGEIEKEEKEKVWYYAQLQSLSKRLEELPHVETFSMQMDLIRQQLQFEAQHIRALMEERFGTADEMVQRAQIRASRLEQIDKELMEAQDKVQPPEPQLCTKLPGTEEDSSMDVPTHPEDGGSSKVEVVFWLLSMLATRDKDDMSRTLLAMSSSQESCLAMRKSGCLPLLIQILHDSDREPGPPESPSSSKDARMRANAALHNIVFSQPDEGQAKKEMRVLHVLEQIRSYSETCWDWLQMQSRDGGKGPEGGAEPVPIEPQICQATCAIMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTSDPLNLALRRYAGMALTNLTFGDVVNKATLCSRRGCMEAIVAQLGSDSEELHQVVSSILRNLSWRADINSKKVLREVGSVAGLTQCALHAAKESTLKSVLSALWNLSAHSTENKAAICGVEGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVSMLRNLIHSKHKMIAMGSAAALRNLLTNRPPKYKDTAVVSPGSCMPSLYMRKQKALEAELDAKHLAETFDTMEKQSLKSQSAKKPLRHMESLVKDYASDSGCFDDDEVPNISTGVETASASVLSMFLGSSFLQGQALPRALAQRRCPEPEKDDGGKPTEPKKPPLPEDDVSLAAEKLANKISSTVAKIDKLVEDISTMHTSSDDSFSLSSEDHGLDWQYGPEEPPEARAHSCSPCRLSDTGGSARREGLSRARALLRLKTAYTSLSTDSLNSGSTSDGYCPKEHMKPCTRAPFLDYRDELQRYQKRPSRLDLKSILGTKPDPPVLRAEPDKPEQREVPERGRKAVTFPGPKALEIGRKKETGGKLPTDPQVHTIKLSPSYQHVPLLGSLAKSSTAVSHHPSLLGRKQAWLPPALLQTAETLSKIPEKLPAQPLAAAEQESVQKYSVEDTPICFSRCSSLSSLSSADNVLDGQSHSENDLDSDSSLEILEMDEGDGEAEDMRREKEKAEMGPTTPVGISQPITIPFPKRDKLFLRDASPSRQEDHTPSSSSENYIQETPLVMSRCSSVSSLGSFESPSIASSIQSDPCSEMISGTVSPSELPDSPGQTMPPSRSKTPLFELGCPPEKETSQFNIQWENNVKKFMEITDFKERFQLPQDLDSMVYFTVEKPNENFSCASSLSALPLHEHYVQKDVELKLMPTFPEKNSLNFAAHEEREEREEQLLEGRRRAEPTSDDDIEILKECISSAMPSRFRKVKSSLLSGQVLHPHTKKPLHVPVYMLVPAHTAVPKHLRATSRELYKDDDSYTDSADGTPVNFSSTASLSDETLRGPKEESEPPRGAGRRREVGTAASPARRSALGSAAPTRPSSACRGRAGSSRDSPVPPGRGAEGKRGQPMAGTEPDVGRSGSPGTRPCSLPGRKDGVREDGAAFQSLCHTTPTEEAVYCFYEHDSDEPGVGKEVPGGGAQPGRALRRERCGGSVPRREPEAKGKAKGKLQHNLIADETPPCYSLSSSMSSLSDGDPGEGEERGSAPRQRAAVGQAQGRSPSPNSEDDLLQKCIGSAMPKRRRPSTRRRTAERKQKLKGGAGRERTAEGRHRSEDLGSDGGSDLDSVEWEAIQEGANSIVTWLHQAAASLSREPSSESDSILSFVSGLSVGSTLQLSLDRTEKKRSGSAAGREVERRERAKSRPEGKKAPSARPAGSTRAERSPAPSKPVPNLPVVFRGRTVIYMPSLAKDAPSPRSTPKKSPVAKPPAPKNLSLSQQRSRSLHRLGKPPEGGDLALPKRSTTPPARIAKGPPSSGSSRTSTPSQHVPKKLPSPSQHPKQSPAQTGKATGPPSPPGPSAKPTAPRSPAPRQHKTQKSPVRIPFMQKPSRKVLPVRAAMPVLEEQEGSGKAKGSAPGGAGGGRLNLVRMSSARSSGSDSDRSGFLRQLTFIKESSSLLLRHRAELAPPAPATSLPRGASPQRSRAALPTVFLCSSRCEELKAAKAAAPTARPLIPRAQPGCKAPAASKPPRRTSSESPSRLPVKTAVPEPFKRYSSSPNISVPRRTGSPSSVLSVCSEASARRRKAGEATEEKPPTAVMKGTWRRIRDEDIPHILQSTLPSTALPLLGAAEEPSPGPRKTSDAVVQTEDFATTKTNSSTSPTMETPRRDGEAPAPTKAALPISFGHEAPAGTFPASRHSSPSRAARVTPFNYVPSPMAVPAVADKAVEKIQA
The following text describes a protein:
Function:
Maybe required to maintain cell division activity in meristematic cells.
Subcellular Localization:
Nucleus.
Sequence:
MDVLANPGPLKDIVLYDQEKHVSSAVWDGQERGALRCHEHTSKLGEWKLKPKQIELVERAGFGFLRRIPAISLDNPLISALVERWRRETNTFHFTVGEMTVTLEDIALLLGLGIDGKPVIGLTYTTCSAVCERYLGKSPASNSASGGMVKLSWLKDNFSECPDDASFEEVERRTRAYLLYLVGSTIFSTTTGNKVPVMYLPLFEDFDDAGTFAWGAAALAFLYRALGNASVKSQSTICGCLTLLQCWSYYHLNIGRPKLNREPIHDQFPFVLKWKGKQNGPTANRDVVFYRKALDVMKPTDVVWLPYENMNGGDMSDRMRKSLLLGRSKTMLISFDKAERHLPDRCRKQFDLFQDIPADVQRWVRKSRGVDGGVDLSNKMESELSEWEMRWENIVPDDVQGVDEADYMRWYLGITRKIVGRPISLSSEFQRTISNVRDILELAENFQIHDLDLERGNMISRIIGLAQDCLRDQVGVTATPETQQQIELGKRMRGKERVRRKGMGKRRKGIDPMEDYGGSEDESQFGPLVEVGQMHLPLSHTNSVYDGTHMYDAVTKVDDMELCDTIPQLPETQDIHKIEGSLLDDTDKFVEESKLQEEFDGEEPTESYDVKKEDKESKVEDDDAAKGFSDVSGEENANREEEDETEMGESVAESSSLDRRGENTVVA
The following text describes a protein:
Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MTTETGPDSEVKKAQEEAPQQPEAAAAATTPVTPVGHGHLEANSNEKQPPQQDARPAEQSLDMEEKDYGEADGLSERTTPSKAQKSPQKIAKKYKSAVCRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKREEDGESGGRRSEAEEGEIKTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKVNERAGLREGSEEKVKPPRPRAPESDTGDEEQDQERDAVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSETEGLVFSRDLNKRGPSQDDESGGLEDSPDHGACSTPDMAQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVATVDTTQENSLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
The following text describes a protein:
Function:
Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
Subcellular Localization:
Postsynaptic density. Cell projection, dendrite. Perikaryon. Cell membrane; Peripheral membrane protein. Note=Detected in Schwann cells at periaxonal myelin membranes.
Sequence:
MQPLVMQGCPYTLPRCHEWHAADRFHHSSSLRNTCPQPQVRAAVTIPAPPWDGAGDPCLSPKLLNGTVGATGPLEPSAMNLCWNEIKKKSHNLRARLEAFSDLSGKLQLPLREIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSKGPYISSVLESAQAFLSQHPFEELEESQSESKDTSPRQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIEHTLEHLLEIQGAMEELSSTLTQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPVKDGVKLVNDLAHQLAISDVHLSMENSRALEQINIRWKQLQVSVAERLKQLQDAHRDFGPGSQHFLSTSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQASEHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGALLHEAIQVPRQLGEVAAFGGSNVEPSVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPIKGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFRSKQYFSKHPQRGYLPVQSVLESDCSETPASSPMLPHADTHSRIEHFASRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSMATESKGELEKILAHLEDENRILQGELRRLKWQHEEAAEAPTLVEGSAEATPDHRNEELLAEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPSESDGNGSAGSSLASSPRQSEGSHPREKGQTTPDTEVADDVGSKSQDVSLCLEDIMEKLRHAFPSVRSSDVTANTLLAS
The following text describes a protein:
Function:
(Microbial infection) Allows N4 phage attachment by binding to the viral non-contractile sheath protein.
Subcellular Localization:
Cell outer membrane.
Sequence:
MKENNLNRVIGWSGLLLTSLLSTSALADNIGTSAEELGLSDYRHFVIYPRLDKALKAQKNNDEATAIREFEYIHQQVPDNIPLTLYLAEAYRHFGHDDRARLLLEDQLKRHPGDARLERSLAAIPVEVKSVTTVEELLAQQKACDAAPTLRCRSEVGQNALRLAQLPVARAQLNDATFAASPEGKTLRTDLLQRAIYLKQWSQADTLYNEARQQNTLSAAERRQWFDVLLAGQLDDRILALQSQGIFTDPQSYITYATALAYRGEKARLQHYLIENKPLFTTDAQEKSWLYLLSKYSANPVQALANYTVQFADNRQYVVGATLPVLLKEGQYDAAQKLLATLPANEMLEERYAVSVATRNKAEALRLARLLYQQEPANLTRLDQLTWQLMQNEQSREAADLLLQRYPFQGDARVSQTLMARLASLLESHPYLATPAKVAILSKPLPLAEQRQWQSQLPGIADNCPAIVRLLGDMSPSYDAAAWNRLAKCYRDTLPGVALYAWLQAEQRQPSAWQHRAVAYQAYQVEDYATALAAWQKISLHDMSNEDLLAAANTAQAAGNGAARDRWLQQAEKRGLGSNALYWWLHAQRYIPGQPELALNDLTRSINIAPSANAYVARATIYRQRHNVPAAVSDLRAALELEPNNSNTQAALGYALWDSGDIAQSREMLEPAHKGLPDDPALIRQLAYVNQRLDDMPATQHYARLVIDDIDNQALITPLTPEQNQQRFNFRRLHEEVGRRWTFSFDSSIGLRSGAMSTANNNVGGAAPGKSYRSYGQLEAEYRIGRNMLLEGDLLSVYSRVFADTGENGVMMPVKNPMSGTGLRWKPLRDQIFFIAVEQQLPLNGQNGASDTMLRASASFFNGGKYSDEWHPNGSGWFAQNLYLDAAQYIRQDIQAWTADYRVSWHQKVANGQTIEPYAHVQDNGYRDKGTQGAQLGGVGVRWNIWTGETHYDAWPHKVSLGVEYQHTFKAINQRNGERNNAFLTIGVHW
The following text describes a protein:
Function:
Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly nuclear in vegetatively growing cells. Translocates to the cell cortex in response to chemoattractant stimulation and is present at the leading edge of chemotaxing cells.
Sequence:
MNTNTNTNTNISSSGNNIINTPTTNNNNKNNNNNNNNNNNSNNSNNNSSNNNNNNNNAVGVKTGKKVNLKVETPVQNNENSYSLTTSGTFKEGDLLINKKGLLIKGESPKNSSVNDRNKNKSLHSNLNPQLLASPTSSESMDFNQGFYNNNNNNNNNNNNNNLNNFNNLMNNGIDSPQLSGISISTPTSSHSFNNTFTNYYNNNNNYNNYNNNNNSNNNNNNYNNSNNNFNNFNNYNNYGNNNNFNNFNALQSSSNSSFDISSSGSSNNYLNNSANNHPHYDTNLSYDLKDLKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKTSYPYIVSFYDAFYTEGSIFIALEFMELGSLSDIMKKTSTIPEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGRSYSFDSEIWSLGLTILECAIGKFPYGSNLPHQQQQPLQQQQQQQQQQQQPLQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNNNNNNNVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPSTFSKEFRSFISECLQKEPTERPTASNLLNHEFVKKYQNFNVEKWTANLKQQQ
The following text describes a protein:
Function:
May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Sequence:
MEHSFCERWMSSWFKKFGRTIATQPGAFLFVSLLVAGGLGGGLYFIDNENSIEKLYTPDSGAGKVEREYVQDHFPTNDSDHFLPSRLATSGRYAAIIVKGRGDLAGNVLHESVMKAAGSLHKNITQIKTEDRGLNYTSVCARWESECVVTGLNLLDFIAAQIPNVAVGYPLEGRIFSGAILGGATLEDGVNTVEKATAFKLIYHLRSSHEEDDESSEAWERAFLSYMATFFSDVIEVTWSTSRSLETEISDLTMSIFPKLAAYTSSLLMAFAVLSCLMIDPVRSKPFLGMVGVLGAGMAVLATIGLMSYFGVRFNALVAAMPFLVIGVGVDNMFILLAAWRKTNPWDSVQDRSANTYAEAGVSITITSLTNALAFAVGAITSFPGVRVFCMYSGIAIVFAYLFQLNFFGACMIYDGYREKQNRHFLTCMKVPVPSKDDQTNCCQQSCCRGDAKARVGQYGKDHNDHLIMLFFKKYYGPFLMKVWVKVVVMIVFRYFSEYDVRVAVVVTEKLAYWDPGVQDIAESMLEGFEGTAFTYGKNVSESWLRDFLTYADRICLNPMVPPFQQLNLADKNSFIECLRDRFLKFQGFTKYAHDILFNEDGTEIIASRFFVQTKQIDSTLNEKNMMTKMRELASETSVEAIVYHPSFVYYDQYIAILPNTLQNLGIATAAMLVVSLFLMPHVVNAVWVTLAIVSICTGVLGFMTLWSVNLDSVSMINLIMCIGFSVDFSAHIVYSFVTSKERSRDARAVHALYSLGVPILQGSLSTILGVSALSTAPSYGFRTFFKTVFLVMVFGLVHGIVFLPVMLSCLGPQGGVVNLQENRSDEAGDVGTPNRYTKKGGNVNVVLQDVNSQGINENPLMTVSMRLWLDHLKEEKRNKGTTESQLNLTANREMSLKQTKIVNPQSSFNNFFQN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. Also able to hydrolyze carboxy 1,4-lactones.
Sequence:
MAKDKFVRTVLGDVPAESIGITDCHDHLIKNGGPEMHEHPDFLMIDVEAAKKEVQEYVDHGGKTIVTMDPPNVGRDVYRMLEIAEAFKGKANIVMSTGFHKAAFYDKYSSWLACVPTDDIVKMMVAEVEEGMDEYNYNGPVVKRSKAKAGIIKAGTGYAAIDRLELKALEVAARTSITTGCPILVHTQLGTMALEVAQHLIGFGANPRKIQLSHLNKNPDRYYYEKIIKETGVTICFDGPDRVKYYPDSLLADHIKYLVDKGLQKHITLSLDAGRILYQRNYGLTKGKETFGLSYLFERFIPLLKQVGVSQEAIDDILINNPREILAFDEPRVYDASKVSSEVVQLKKDLKLL