lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (By similarity). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, Stress granule.
Domain:
Can mediate both protein-protein and protein-RNA interactions via the NTF2 domain and RNA-binding domain RRM; protein-protein and protein-RNA interactions are essential for undergoing liquid-liquid phase separation (LLPS); The acidic disordered region acts as a negative regulator of phase separation; The NTF2 domain mediates interaction with CAPRIN1 and USP10 regulators, thereby regulating assembly of stress granules.
Sequence:
MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQNDIHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFGDSEPELDEESEDEVEEEQEDRQPSPEPVQENANSAYYDAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKHLEELEEKSATPPPAEPASLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQPRVDAKPEVQSQPPRVREQRPRERPGFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEEKKTRAARERETRGGGDDRRDIRRNDRGPGGPRGIVGGGMMRDRDGRGPPPRGGMTQKLGSGRGTGQMEGRFTGQRR
The following text describes a protein:
Function:
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity).
Subcellular Localization:
Secreted.
Domain:
The mature protein is largely unstructured in the absence of a cognate ligand.
Sequence:
MCLLRLPVTLLVLCVALNELKATSIASDTGHQVGKRKCNTATCATQRLTNFLVRSSHNLGAALLPTDVGSNTYGKRNAPQISDRELLHYLPL
The following text describes a protein:
Function:
May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MFQWYQRSLIQRPLLTQSLTTACLFAVGDSLAQQAVEKRGIAQHDVARTGRMAFYGGGNVQPFPYKLPLLTVVAVFGPLATKWFQVLQRRINLPSAQRTVVGRVAADQLLFAPTMIGVFLSSMSVLEGGSLSEKLERSYWPALKANWTVWPFLQLVNFALVPLQFRVLTVNVLNIGWNCFLSLSNNVGSQDVPLVA
The following text describes a protein:
Function:
Heme-containing signal transducer responsible for aerotaxis, the migratory response toward or away from oxygen.
Sequence:
MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLGDAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQEMFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLKAIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSRSVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEMVKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSEDTKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISKEQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAVTEAVKEAIWMIGMVQELGIEQKNVNVYCDNQSAIHLTKHQVFHERSKHIDVRLNFVRNTVSKGRIKVEKVHTDDNAADMLTKSLPVSKFKYCMDLVSCYILYTLNPDVSGASTLFNDIFGAFGIGNNPETVPCCSWENSSPATSNCLYHTVTKFLESLIDNTHNCLHLRLLDKHCPSDPRTEMQVRFLELGSRKPSTCYCRKEDVESFVWAICRRIVPPKLLGEHSNWRILRTNIFKFIRLRKFEKFSLKECFHNLKISKFPLLHDNIHNGCSVLGITDIARHVILGCWIFWFFKCLVSPLFQANFYVIESEFERNEVLYYRKSTWRKLIREAECMKNDTFRPLNVSAVRKILKNRSHGFSRVRLLPKKTGFRMLANLQASSKLRLNSTSSKFQSDGSVNKVLNDVQVVLRGSLTKEREKFGSSVFDYNDVYRKLVPFLSRLKKRWSKMPRVFIVVSDVSKAFDSVNHDKLLSVMEDVLSDDEYALEKFTQVFCTKKALKVHHTLALADQDFVTVSSGKIKSIPPPKSLDGVLVNKALDRTIRKADINTTLKEHIKRNVVRQSDKKFYLQNVGIPQGSVLCTFLCSLYYGHMERNVVYPFIEKARETNGASSSAGGKNGKQKFACGCEYILLRFIDDFLFISTSEKQASMYFSRVDRGFHDYNCYMNKDKYGLNFKMKNGQECRSSSRPYVGRDGVSFLRWSGVLVNCSTLEIQADYTRYLDFHLSSTLTVSRQGKVGEQLKSKLRAHMSNKCHPLFYDSNVNSPDVVRLNIYQIFLLCAIKFVCHLSNLSILPKFTPQFITNAIVASVRCTSKFIEKKMYSFSGVDIAFRPKYEVKRAEVLFLGLYAYNRVLEKKQTRYKNLIPFLRTKLKACGEIAHMSSELKYAIHDEHSSVFWRIKY
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAASSGSPQLATEDHLRKGEAVSGLHAVVAGSVSGLVARSVTAPMDTVKIRRQLQLASEHKYHGILHTFRTVAREEGVRALWKGNVPASAMYVLYGSLQFGTYAWLNTAAASAGLPPQAHSLAVGALAGLVSSLLTYPLDLLRTRLVANRSAHFFSLRRQARVIWDTEGPAGFFRGGAWAIAATTLTTGLIFGIYETCTIAADTYGLPWLAAAASPTAGLVSKAAVFPLDTVRRRLQIVDAKHIPFFTRDPGAYSALRGTRFLGLAVHMVRAEGIASLYKGLTMALCKSTPTTVITLWVYQRCLRLLEPTRAPQLPA
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAAPQAPGRGSVRKTRPLPVKTSLNNPYSICWGVLDREDMHFILQTLEDRIQSLGLQKIEDRKRKKKQPPLKKQSGDTSSIDVDTGEDLKKEKPKGDAQASGWTPVDVRKQLAIGINEVTRALERNELLLALACKSAKPAIVTSHLVQLSVSRGVPACQVPRLSERLAPVLGLKCVLALGFKRNTTAFGEELRAILPRVPRLNVAWLQDALEDPRENLQTESLESQDEEILDTSFEDLSKPKRKLAEGQQPVVLQPLKIKKLIPNPNKIRKPPKSKRTASK
The following text describes a protein:
Function:
Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs.
Subcellular Localization:
Cell projection, dendrite. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MLPSQEASKLYHDNYVRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVNTPKPGYFGLFHYCVGSGLAGRELACRGSFTDFSTIPSGAFQAAAFFVLLSMVLTLGCITCFALFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGEKTGKYSLGDCSVRWAYILAIIGILNALILSFLAFVLGNRQNDLLHEELKTESKGGRCATRFCRHREDIRPSTRSRTSSRGRRPGRSLPVLPLICRRWPRSAPGRTARTGAVPAARRAHVHTDTAIPRTPPAPHLRRRRGRMPQTRFV
The following text describes a protein:
Function:
Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAASEENSALFPIFILTIMALPLVPYTVMKLCRAASRKTKVIHCQCADCSRSGKYRKSIFKRISNFSTCSNLTLVLLWIIMIFLVYYIKNMSGEIQVFEPYSILGLEPGASDAEIRKAYRRLSILYHPDKNPDPAAHKHFVEYIVKAYQALTDPISRENYEKYGHPDGRQGFQMGIALPQFLLDIDGASGGILLLWIVGVCILLPLVIAVIYLSRSSKYTGNYVMHQTLSTYYYLMKPSLAPSKVMDVFTKAAEYVEIPVRRTDDEPLQKLFMSVRSELNLDLKNIKQEQAKFWKQHPAIVKTELLIQAQLTRESAALSPALLGDFRRMLELAPRLLEELLKMAVVPRTAQGHGWLRPAIGVVELSQCIIQAVPLSARKTTGGSSEGIASFLQLPHFSEAVIKKIARKKVRTFQELRDMTVEDRAELLTQAAGFSSAEVQDVEMVLEMMPSLTVEVTCETEGEEGIQEADIVTVQAWITLKRGSGLIGALPHAPNFPFHKEENFWFLLADGVSNNVWFSQKVSFMDEAAAITTASKTIQEAMEVSGASVKETSEAVKRAVEKVRGGSRLVMGKFPAPTEGNYNLTCYCLCDSWIGCDKKTNLKVKILKRTRAGTRSGHVSEEGLLVEDGVEEEEENEEEYDDYESEYSEDEEDEKDTKKKGPAANGTVNQKGSSSEGSGTDEE
The following text describes a protein:
Function:
Involved in the multi-step bile acid 7alpha-dehydroxylation pathway that transforms primary bile acids to secondary bile acids in the human gut. Catalyzes the oxidation of C3-hydroxyl group of CoA conjugated bile acids generating a C3-oxo bile acid intermediate. Can use choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA as substrates with similar efficiency. Highly prefers NAD over NADP as cosubstrate. Also catalyzes the reverse reactions; in vitro, the preferred direction of reaction depends on the pH. Has very little activity with unconjugated (non-CoA) bile acid substrates.
Miscellaneous:
MISCELLANEOUS: There are three genes for BaiA proteins: baiA1 is identical to baiA3 and encodes a polypeptide sharing 92% identity with baiA2 gene product; MISCELLANEOUS: Reaction mechanism seems to proceed via a nicotinamide-OH(-) adduct, which is proposed to be involved in proton relay instead of hydride transfer.
Sequence:
MNLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSRDAVMAAVGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIMDINVTGVFNGAWCAYQCMKDAKKGVIINTASVTGIFGSLSGVGYPASKASVIGLTHGLGREIIRKNIRVVGVAPGVVNTDMTNGNPPEIMEGYLKALPMKRMLEPEEIANVYLFLASDLASGITATTVSVDGAYRP
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MHFKLLLLAALVLLFSTATHASVGGYICPNDRKKLLTVLVKALINVEGDFSTPYYGIKGFKALNEQVAAVLVKDNCAHIKKYYKADCTPEENFQGLSAWNLLGCSGKLHTDATITNLRTVLESDKSTTSDIRYAAETLKLLGAAIPNGAKVAQLIQAKLKEDDSLQSLGHALHAAALLGTSGNFIQDRIEEVVVQADEVDGKLLQWEGGLTTTSLLITGLLRFPGAKPLNAQQAEKLATYLLTRRTVQTPKGALALLEATTSLASSDISPVSITIAGPAQVTLDKPELKVHISDILGRALKAPPTPVVAQSATRITDDVVVLSKQPLSPGGTPVEFVLPLRLEPGQYRIALTAGSHSTTLTVRVLGPVTLEWLQIGLGDADGSAAPRLTKLTHPSKLPSPLRADSSHHLVAKFAISRVVHQAFLRLYSGKKEIIFVAEPDNSKLYKISVNLASELAHSGTFEMELILGDSVMSNPIRWVIGTIEVSLSTPEPEKKSLRGPKPEIKHLFRQPEKRPAEVVSMLFTGLTVSPLLLLFVLWWKVGVNFGGFTTLSVPFHVGFGGILYLFFLFWWKLDMFTTCAWLIPIGGFTFLAGHKLLSHVAKHKKA
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10. When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex; The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity.
Sequence:
MDSPSLLEVLQVQQVEKLISPSLRFILAYFTHRYPRFLLRAYNSFDGIYLLVKLLLEKSQLKKWNATSVERRFQLKRVIAVRDSSIIAEEFPQESESATSLNGIDVLKKLFLTYCIPYLLEKCESLTTVKENHTAVSILSLQARDKQKGALSVFYSKIKILLVRLKKILHFVFRLIRKSNTYLQWLYYLLYALGKTPYTNLADHILRQRVIYNVENIHSRKLISTREKSSLLTSIADHSMEGFLIIIQLIDWWQSNNYESHLKKGEVAFTELAPPKLPFEINVSTTDICKICGEKIKNPAVLSTGFVFCYPCIQVWLQRHPFKCPVTNLELSRKGESFWRLMI
The following text describes a protein:
Function:
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Sequence:
MTPAEIAPKDRLIVALDLPSVDAAEAMIARLGDSVTFYKIGYRLAYAGGLPLVARLADKGKKVFLDLKLHDIGNTVAQGVESITRLGATFLTVHAYPQTMKGAVEGRGGSNLKILAVTVLTSYNEDDLHAAGFRLGVAELVEARAQQAQVLGIDGLVSSPEEVGALRKIVGHQMSLVTPGIRPAGSASGDQKRIMTPGRAITAGADYLVVGRPVVEAAEPKAIADAIQAEIGQALGA
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MHLPMEEGREKSSTQQDSEITAQDERIDPNATILSHSVLSLLVPKVEYVQGSVKEITKTQNVLAKSVEQENEKFRQIGYIHDLSNTFIRCRRCRFKLVNIRREMLNLSDRMNKLKKRAARLKSIREKQQLKQAQEEAERQAYQASLLAKPAKHLTNQN
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MSLADELLADLEEAGDEGDEPGLYPGAEGADGADSDGEGGAEGPGGLADIPEEMEVDYSGTESVTSIAKLRHSKSFAEIMEKISQYIGNQRKTSEVSGPVEADPEYRLIVDANNLTVEIDNELSECPACSLPPTTLSTKGCPLFAVLCALELGNNLDKCKNNETLQQILTNATIMVVSVTASTTQGVLLGDEELLRLEEACDMALELNQSKHSIYEYVESRMSFIAPNLSIIVGASTAAKIMGIAGGLTNLSKMPACNLMLLGAQRRSLSGFSSTSLLPHTGYIYHSDIVQSLPPDLRRKAARLVSAKCTLASRVDSFHESSDGKVGYDLKEEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKHANRMTFAEIEDDAYQEDLGFSLGQLGKSGSGRVRQAQVNEATKARISKSLQRTLQKQSMVYGGRSTVRDRSSGTSSSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSNMAEFLKVKREAKETYTE
The following text describes a protein:
Function:
Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSGDDDWWTSSNEALLVSLVTPSDTGVKTLDTFHPEYTNNIFGEKEQIFGYKGLRINLQYNASDMLPNLKVSYKKKYQPTADEEALDINEVLSEFLPEIAFQKQSDFETRLKSIPDNWTPPGTLVTSFTNKDGEYEVYSGKITDPAVKQLLNRIQILVPFFVDGGTPIDMEDPDVDRWTIYFLYNKRPLLNQPDKFSYHFAGYSTLYRYYAFQPPAESESKTPTDTPTFSVDGDFDLDTLPCRTRISQFIIIPPFQQKGLGSRLYSIIYQQYLKHEPTIELTVEDPNEAFDDMRDLADLAFLSKQPEFQALKIDTSVEIPEEGKAPSNIVDQAAWEACRKKFKIVPRQFARVLEMYLMSQLPESVRPGLGAPEDEDYEEQSGRSKSKGHEKALPKPTPEDEHTYRLWMMLVKRRLYVHNRDALGQLELKERREELAKVFAGVEFDYARLLIKAEEQGKLAQADGETAGDQVPATPSAANGKRKLDEVEQAEGTAAASSKKAKVESGHA
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
Sequence:
MDTFKRWLNKPKADDKSLLARFFHADRSLTAVASELDSFDGRAEPDRCTRLVSRLRQNQDKVLAITNLIMEELLGEDRDPRAFRAKFPEEVLQENLAGQLWFGAECLAAGSSIMNRETESKEMRPLAQAVTKSLGNVRVLLRDQCLKNNVPNSKTLHLDLNDSTTEQLYESLKIFDRLFAEFELSYVSAMVQVKSRHEYEMQQWIGVLFSETLQRALKIGLLDQEMVDAFDPGLMFSIPRLAIVAGLVVYAKGPLNMDMPGDQLSEMFRPFRTILIKIRDLLRNLNNQELYQLEKLLCTNEDINTKVPLGSSSIEAPSPEHSSHPTTSSSQNNNNSSNNNHSSSSTNTTSTTTTTAGTTNTHRTVERLVDQRNNNHNSNSNSSTNPTVEAATLRSPSMLSLSATSTPTASPAPSPTPSHSIASTSSAATSSTNPPADWSDGDDEDEDDDDIDVDEEDIESSDDGTDEEQLLKDIVSADCASGYLIPNTNLGNLLQPQEVPLTDNFVASEDDEYGTAEQQGHQGLEEDEPSTSAAMLAATRTLQRLRLPSSDNEPLAEPTTIKASEEHMQQPSGRHRDSHSHRHHQRHHHHHHHRHPHQHQHRQPHPHRTTRSGRKRCSLEAADPERIQPDREQNLASGDTSAASSLSDDVSLAMRNTTARLKFKSTENLLHRLFVCIAGVADQLQTNFASDLRQILRSVFLMNMSTAQEEIDIPEKTKESELFEFRASENDVIQESAGSNQSIYSAEEVNPELDNVFSAGGGNQATGQRHSAGASMQRNNTIDLASQPGEGSPSGATTATSRSHVTRSRSLGDQEAASSATSSTAQLRQLEQQQQQQQLQIQLQRQRNNSVGSNTPSSASSTSSSSEQNSPVSARSGSRRRLQSNNETQMPSSATSTSATLSPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCYVREVRSGMGVQGVQSVQSVQASAS
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Sequence:
MSKEKLPFVVTAGQMRSAEEAAVVRGTTWAALMEQAGAGVADAVLRYAAPLANRQVLVLVGPGNNGGDALVAARHLADAGALVTLYVWRRSGVDANLQACRERAIPELSAATDGDGSLLAQALRKAVLVLDGLLGTGARPPTADLATIIQAVNAERTQRSDLRVVAIDLPSGVGADDGQVPTVAIRADLTVATGLIKRGLLLWPGRGYAGEIVVAPIGLSSLDGVLTMSELLTASQARTLLPPRPADAHKGVFGKVLVVAGSINYPGAAVLACAGAQRSGAGLVTLATGRTVLSLATLPPEVTLLPVAEGDWGAIGPAAVDDLAEHLPGYQALLLGPGLGQAEATRKLVLRLFGLDHTRSRARVGFVAVGEPLTNQPQQTVALPPTVIDADGLNILATAADWFERLPPEHCVLTPHPGEMRRLLGVSELPADRVATAAEAAQRWRQTVVLKGATTVIAAPDGRTLMYDGANPALATAGSGDVLAGVIAGLIAQGCLPFAAAALGVYLHGAAGARARMAFGDAGVVAGDLLPLLPSVMQELRTG
The following text describes a protein:
Function:
Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT complexes. Seems not to be involved in endosomal transport (By similarity).
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides (By similarity).
Domain:
The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody; The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex.
Sequence:
MAKSSLGQDSDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRSTLRTKISGYMDRAENIKKYLDQEKEDGKYHKQIKIEENATGFSYESLFREYLQETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGDEGFGNTQQSSGLEEIKQSLRSHGVVLEINYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQGRFSLGYCDLDLRPCHETTVDIFHNKHTKKI
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
Miscellaneous:
MISCELLANEOUS: Although strongly related to metalloprotease proteins, it lacks the JAMM motif that probably constitutes the catalytic center. Its function as protease is therefore unsure.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALNAPSGSCSSKVLLHPLVIMQMSEHYSRTKVQQGPTVKKVFGAILGRQNGRQVEAINSFVLKMETEEMAEPVTFSTEHLLQRADQYLEVFPELQVIGLYCAGEDDNLTPEEKPLLSKLTNAVRNSEKAGQIDATLFLKLNSITAGTTRKLPLFAFEADVTDQEKHKPIEWILVSEESERVGVNHIAKLSTKHGKDGKSVGKKHAEAQDAAMSMLQNRVDLIVAYLEKVQDGTLQPNFEILKEANLLAQKLKTIDRYAAEFTDSFEKEEKTMTVFSLMPRLTTLLGNMQNVWNKLSAQRADLLADDGFHGKSTSRWAHPVRFKSQHLGRPQQADDDDYFDDEDLENDMSGPRRKIHAADSPAGSRRRRVPPRAMNFLGRNSGMQAATDEMELSGQEENMGSNYIPDVPRPSATAHNESDESSQAS
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MEEQQWSSFPELPQFLIENLQNNDYNAPFPVQVAVLEKFFASDVDLAIGFPTGSGKTLAYLIPIISCLYKRIVQRLRAIIVVPNRELAIQVYNVVCALIQNSKLTCAILSSNYWCGESSSYTNVPDIYICSSLSLSSYLLDVDDKLLSDIEYIVLDEGDVILEQPLENWLDHVQRSLNSDPIPEKFTIPLVTAPPKDRRIRKILCSATLSRNSKQSEDFKMQFPEILISSDKSRYVIPNHLKEEFIIAERQNKPAILQSLTTRFQFILCFVSTTKRAVALANIMRTLLAKTDFQVIEFAASLKSDKKNQAFESVDQNSSRLIICTDSLARGINLPYIDAVINFDAPASARTYIHRIGRTARGGNSGTCVTFLLDSELILFRDIISKIDGANPQKTEPKMVGLTGKFYRETVKGFDSLKPRKLPQKKMAKYQEMEEEEMNEIEEEEKNENGEEERNEGESNNDTEGDYNQNEEE
The following text describes a protein:
Function:
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
Sequence:
MTAFGVEPYGQPKYLEIAGKRMAYIDEGKGDAIVFQHGNPTSSYLWRNIMPHLEGLGRLVACDLIGMGASDKLSPSGPDRYSYGEQRDFLFALWDALDLGDHVVLVLHDWGSALGFDWANQHRDRVQGIAFMEAIVTPMTWADWPPAVRGVFQGFRSPQGEPMALEHNIFVERVLPGAILRQLSDEEMNHYRRPFVNGGEDRRPTLSWPRNLPIDGEPAEVVALVNEYRSWLEETDMPKLFINAEPGAIITGRIRDYVRSWPNQTEITVPGVHFVQEDSPEEIGAAIAQFVRRLRSAAGV
The following text describes a protein:
Function:
Catalyzes the oxidation of formate to carbon dioxide, with coenzyme F420 as the electron acceptor. In vitro can also use methyl viologen, 7,8-didemethyl-8-hydroxy-5-deazariboflavin (or FO, a hydrolytic derivative of coenzyme F420), FMN and FAD as electron acceptors, but not NAD(+) or NADP(+).
Sequence:
MINTNDMFYAKSSDAEIAEAGEYGGAVTTLLKFLLKEGIVDAVLAVDSSADLYDVVPILIEDPEDVVKAAGSLHFGTLNLAKVVTRYLDGAQDMKIAVTVKPCDAMTMVELMKREKVNADNVIMVGLNCGGTMPPVKGRQMMEEFYEVDPDSVVKEEIAKGKLIVETEDGTEKEIPIDELEDEGFGRRTNCRRCEVNIPRMADLACGNWGVIGPLAGKATFIEVCSPKGAEVLEKAKEAGVIDLEDPIPKGIEIREKIDGAMVKLADKWQGNDWEDKAGREIFSVLTEYMDDFSRCLKCYGCREACPICYCEDCCLEANNGPDWLSKGEIPPSPMFHLERMLHMVESCTNCGQCEEVCPGEIPLAKIWHEVNAKMKDTFGYVKGTGDEKPPIAYFPVGK
The following text describes a protein:
Function:
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Domain:
The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.
Sequence:
MSRNRAAMVSAFRLFLRPATTTTHRSLALRLAPGTTFALHLRPCHELQQHRSFASTAEDGETDKHKKPTTGEDIYVEYVNGMPHMTVRLPSRNELCQFALKPISHNVGDLLAMLRAEDRGIDRAAVINKHGVRIASSCTIESLLDDSFSIQINNRTLDVNPPKRDKVTLESMDKVGDVRKVIAQLYEAFNVGEYQLEKSNQLAKELETLRYELEPLEEKKLELSKKAARRTNFMTWMGLGLMSVQFGILARLTWWEYSWDIMEPVTYFVTYGTTMAMYAYYCVTKREYMMEDVKNREFSLSLYRNAKKVQFDVEHYNELKRKSAELEYNLRRINDPLNMQLPSHLVRTQENTPPTLTEEKAERKYT
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRLIKQPLFRCASSGHLMKESLVFIHQTRTFQVGKFTSNEKYNEKIEDINERSNPQWDNAGLENLLNQLQDSVEQSASDDFMGELEKKIEVENEEPPLMGTNLWPSPSSSIVGLIDRPFQVDSTVQHLVNLIMRDGKKAKAEKIVATALSIIQKETGENPIDVLKQAIAEISPLMKLVSAKRFNKSVEFPMPLKERQRRRIALQWILGECKSSSPKRLSDRIVKEIIAIRSKTSNCFKKKDHLHRMCLVNRGNAPVRI