lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDTSSVTMHTERACCHQAQRAVAAMLDKAPSWLIWTAVLYVGLPFMLYWAVPYLFYHNKTKSRRIAIYVLGDLGHSPRICYHARSFSAAGWEVELCGYLEEQPPKDLLDDPRVTIRALPGASNAGKSLGQTARKVVLQTCHIVRQLWELRGCDYILIQNPPSIPLLPIVAIFKVLTRTRLILDWHNFAYTVLQLRVGRFLHPLVLVSYAVEFLFSRMADYHITVTAAMKDYLVQSFLLPARRIAVMYDRPGEQFRPLPAGERGAALAEPFIRGYIPAGFDVQRGDTILVTSTSFTLDEDINVLFGALKIYESAAAKFDTTLPRILLFVTGKGPLKGKYMEEVRNYKWERCTIHFLWLSAEDYPRLLQLCDFGVSLHTSTSGLDLPMKVLDMFGSGLPAFVMDYPAIGELVQDRVNGLRFTTRRELEQCLIFAIKDEHTRKVLKENALLESKNRWHQSWASAMSELQVVRQS
The following text describes a protein:
Function:
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cell projection, kinocilium.
Sequence:
MDADSLLLSLELASGSGQGLSPDRRASLLTSLMLVKRDYRYDRVLFWGRILGLVADYYIAQGLSEDQLAPRKTLYSLNCTEWSLLPPATEEMVAQSSVVKGRFMGDPSYEYEHTELQKVNEGEKVFEEEIVVQIKEETRLVSVIDQIDKAVAIIPRGALFKTPFGPTHVNRTFEGLSLSEAKKLSSYFHFREPVELKNKTLLEKADLDPSLDFMDSLEHDIPKGSWSIQMERGNALVVLRSLLWPGLTFYHAPRTKNYGYVYVGTGEKNMDLPFML
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKSAFFLCVLIVFFHQCFGDQNEEANGNGVVKIGVVLDMDSLVGRMGNMCISLGLEDFYKDHPNFTTRLTISARDSGGDVVKAASAALDLMKNVEVQAIIGPLTSAEAKFSVDLANISQVPILSFSATSPSLSSTSTPYFVRATLNDSVQAKPIAALFKAYGWRQAVVIYEDTEFGEGFIPYLNDALLEVGSRLQHRTVLPTSASNELINEELYKLMTMQTRVFIVHMSSPIASRLFLLVQQLGMLSKDYAWIITDGLSSLLESMDPSIIASMQGVLGVKSYIEKTKRLANFTARWKQYYKDEYPNEIEIPELNVFGLRAYDATWALALGVEKSGTRAVRFQQPIVGKASTNSTDLSTLRISPVGLKLLSAILDTQFIGLTGDIHFINGELQDSTFQIISIAGKGTREIGFWSPKYGLSPDLNQETLKKKSGYTASVVDLRPVIWPGESTAVPKGWVIPTNGVKMKIGVPVKYAFKEFVNVERDPGDNRLSVTGFSIDVFGAVLDVLPYALPYEFIPFEDGDGKMAGTYNDMVDQVFLGKYDAVVGDVTIIANRSNYVDFTPPYTESGVTMIVPMKKVQKSRAWVFLKPLTWELLLTTTWFFFFQAFMVWFLEHRINDDFRGPPMEQVGSALYFSFSMLVFAHPNLASILTVEQLQPTITDVQSLIKKHEYVGYQRNSFVKDLLLKWGFPESKLRTCGTVDEYANALSMGSSGGGVAAIFDEIPKIKVFLSHYHDKFTMAGPIFRTGGYGFVLPKNSLLLSDLSTAVLNITEGDKIEAIERAWFGKKDRQPVSSSAATSSGLSLDCFWGLFLIVGVASIGALIWFSICFWNKNHSRFGVDEQGLCQQIKVIATVFNERDHSFHSSTQRKREKEVELNRDVALANGESPLSIVVSREGLPTEATTPTRSSSASEDDDDGSSIESLSSSDYDDHDAPTQRRDTP
The following text describes a protein:
Function:
Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. This protein is specifically required for the kinesin osm-3 to dock onto and move the IFT particles which contain these precursors.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MNAMLNIKEGEFTSTIYTLIHEHKFNDAIRILQYQHERNPKNLAALSLLGYCYYYTQDFQNAADCYSQLSYNYPHHSQYKLYHAQALYHAFKPAEALNVVTTIQDDDLLNESIKLEAAIKYQEDDLVNCRILVDQLPTDDATVLINTACIDYKEGNYSEALQKFNQATEFSGYQSGLAYSIALCYYRRGDYNSSLQLISEIINRGIKDHPEFHIGMVTEGFDVNVVQNSMTLHESALIEAFNLRFAIYYKTKDFKAAKECLTDMPPRHEHDYDPVTLHNLAINTANTDFGDSSAKLQFLLGSNPFPQETFANLLFLYCKNDYFGLAADVLAENPHQSFYCLNEYQFNLLEALIYMPTSPEESLKKLEKLDKECMTRLRKIAVEIQIKKEQKTSDKDDSLEMRNLIESYEDELELYLPVLMTHAKYYWDKRDYLAVEKLFRASNEYCNEHHTWKLNVAHTIFMQEKKYKEAALFYEPIVNRKYDGGILEIPAMVLANLVVCYIMTNQTDEAESILKTVENAEENALMSNPNEKYFHNSIISLVIGSLYCSKGNFEFGMSRVVKALEPPEKKLGVDTWYYAKRCIVAAIEMMAKNILVMRDSVVMEVIQFLSSCEIPGRNIYTVPDDLFEQAAESKVKCNVTYEARMLKAALLTVFHGS
The following text describes a protein:
Function:
Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
Subcellular Localization:
Cell projection, dendrite. Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MAGGNDLSHIGRLKKEEEKALFETKDKLQQWQKFDEDYSALKSRLTTLPDKVSHEVMVPFGKFAFMPGQLIHTNEILVLLGDNWFAERSAKQACEIINRRQAYVQKMIGDLKKQQYLLESRLGFVSDMKHTVEGRGDMVEIREEYDEKKEKKWKAERRAKKKASTSSKTPAAKPSPSDKALSGNHDDGTEKNEPTAEDLLWARLDELERQEEELDEAAMTDEDEEEEDEEDEEEEEEEGGGIHQSTIPHDAHKHVHWVDQDQSLALDLDQEDDDDEEEDEMEEQKSMSVIRFSHTKVSKEEHPSEEQAKDASPRSPADIYELYQTRSRDADTSNAGVEGQPKSILKHSDVHQPVYSPVIRQAEEKRQPLPAPVSAFTGSIVEHSNSPQPLIPQPTDQGQGSKRVSKFKAARQGRR
The following text describes a protein:
Function:
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Sequence:
MVKIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQNAFCIDRAKKHDIPVYINEPKQFDSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKGIDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRKCDIRPDDSKEQLEEKVKKLEYELYPSVIAKIVK
The following text describes a protein:
Function:
Could participate in the normal pathway of protein export.
Sequence:
MTMYATLEEAIDAAREEFLADNPGIDAEDANVQQFNAQKYVLQDGDIMWQVEFFADEGEEGECLPMLSGEAAQSVFDGDYDEIEIRQEWQEENTLHEWDEGEFQLEPPLDTEEGRAAADEWDER
The following text describes a protein:
Function:
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
Subcellular Localization:
Membrane; Peripheral membrane protein. Cell membrane. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes.
Domain:
The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3; Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains; The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1; The PDZ 1 domain interacts with BCR; The PDZ 2 and 4 domains do not interact with the C-terminal region of SCARB1.
Sequence:
MASTFNPRECKLSKEEGQNYGFFLRIEKDTEGHLVRVIEKGSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNAVTLLVLDGNSYEKAVKKQVDLKELGQSRQEADLRDENVAPVMNGGVETWTQPRLCYLEKQGNSYGFSLKTVQGKKGVYMTDIIPQSVAMKAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGNRIVFLLVDKETEKRHSEQKIEFRREAASLKLLPHQPRIVEMKKGSSGYGFYLKAGPEQRGQIIKDIDSGSPAEAAGLKNNDLVIAVNGKSVEALDHDGVVELIKKGGDQTSLLVVDKEADSMYRLAHFSPFLYYQSQELPNGSVTEVAAPTPVPPEVSSPDPTEEVEDHKPKLCRLDKGENGYGFHLNAIRGLPGSFVKEVQKGSPADLAGLEDEDIIIEVNGVNVLDEPYEKVVDRIQSSGDNVTLLVCGKKAYEYFQAKKIPIVSSMALPLAIPADSQGMLAELEYNLHEAKERAHSTASNSSSNSEDTEL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MMQSGSCQLQVLSDLAQENGTWKNPVLCSILSQELQDQDKVNEFLAFEGSVLLDMRIKHLMKSKQLTQATALAKVCSDHPEISSKGSFKQAYLVCLCSGSPNEKLMQEIADIDCKDALEMICNLESEGDEKSALILCAAFLSRQLQLGEMYCAWELTLFWSKLQQRVEPSVQTYLERCRQLSVLTKTVYHIFFLIKVINSEIDTAGLATCIELCVKALRLEASENTEVKISICKTISCLLPEDLEVKRACQLSEFLLEPTVDAYYAVEMLYNQPDQKYDEENLPVPNSLRCELLLVLKMQWPFDPEFWDWKMLKRQCLALMGEEASIVSSIDELNDTEMHEKIEDCQDENKDISMNGLSGCFDEATNLLRSIRDRKQKNREIKKLRERGFISARFRNWQAYMQYCVLCDKEFLGHRIVRHAQKHYKDGIYSCPICAQNFSSKETFVPHVTLHVKKSSKERLAAMKPLRKLGRPPKATPTNVNKRNNTIVKQEQRHIKKNNFYGADFIVFNDNDGSDDENYEKDKSYIPEITPVQKPLPVNEFTCPVTLCKKGFKYFKNLIAHAKGHKDNEEAKRFLEMQSKKVICQYCRRHFVSVTHLNDHLQMHCGSKPYICIQMKCKASFNSYAELLGHRKEHPVFRAKCMFPKCGRIFSEAYLLYDHEAQHYNTFTCKFADCGKVYRSQTELDKHTEDHTKSEKMLQLDGETIVPQPLKGNDDEESVLPQPLENNESIEEIHPEEALMLLPENSLNNCVKSEKYVTEEIKYISPLIKRTKMAAGEPEQTNPISNGSAERHIDAPAKPEPVVLTSSALMPLLGQKIRENMARKGKLLPESTKTDNSAPVIQQLCSTVEDTCNDLPVSQEAKDDIGISESQTIAMDSVKLEPQVLSTKSPEEERSHLPLMQYEMDYQNLPPPKTQLEENMKTSTNLYNVPLKTLEGITLAPAQNSLGTPFVPVLPLATPVQKFTCQVEGCTRIYNSCQSIGKHMKTAHPDQYATYKMQCKNKRSRKTDKLQNLPSDSKIVYFLPSQASTPTSDVFPQQVKNSLNSTCTSQLQQLSNVLFPTRLEGMTNSLLPHENGLKAGVSSHIKSETENTLDSHMRSLSNATLPSQLDELEKQGMPLNIDSGSDPFLPLPAENGPISLFSSPADNCPPSVFSQMENNINHFSSQLEGNTTFSKDESVDVLFPSQVNNENFNETSPQLLVAEKVKKDNRRGPDGKDKKPKHNKRAKWPAIIRDGKFICSRCYRVFSNPRSLGGHLSKRSYCKPLDESELSPEALQLNGQSSLLASMILSSNALSLQQQQESAFNPEVCFKEPSFLQLLATENRSPAFLQNLFPRTNMTSLNTSENAEGSEIIKQALETAGIPSTFDTAEMLPHIMTPSCITSSSQINATILPSPGVSPLLPTVCNPTTLLTDQNRTFNAKISSVEECSSFPVFPDDLILKTIENGLGSNVVSNCTAPAHNFGNNHSRVSVISSIKGSEICSLNKKRGSSSKKKKKTASSLLVPNISQKLVINDLTSLELLPRNVEENMQIPAENLRSNVLANCETEVLIENLTQKMSSVDNELTASVKENFKTGNETCTEIAPLLVKDDNSNSQVILGSCIEENSNIDPSEDNIIQNFQKTLEIIKTAMNSQIVEIKTEIQDVSVEPSERPQIRTVECALENLSQNVQSAGPSGQVVHVQNTVIAKSNLSQSETSLKDDSQIMEILEGLKKLKLESETPSQIFDNIIHCLPTDALLPQILVPVVTAESTSLVQPPSETRLPIGEKVHKPFTCQAPGCSYSAMTKDALFKHYSKIHQYTAEMILEIKKHQLKYAPFKCVVASCPKTFTRNSNLRAHCQLVHHFTTEEMVKLKLKRPYGRRPQNKTTSITPRTIELQNIELQNIELNKHVLIECKNQSHLAEEPEVKERMCIESEKVPEKVMPEIVVPESIPAALEKLEKPPQVVPIPLELHNAATPTTNTQIQPKVRKIRRHRKEKEERRNKKTVQKSLEIPTTYSPYRPYRCVHQGCFAAFTIQQNLILHYQAVHKSDLPSFSPEAEEESEPSKEEDIRKEDCDETETVVKEFRCEMRNCSRIFQEVTSLIQHYMKLHEMTPEEIGSMRSSLNVARFPCDQSECKSSFTDYLNYIIHLETDHGIKIKQNKTDDGMYKCDCEGCDRIYATRSNLLRHIFNKHNERHKEHLIRPRKFLTPGQENISSKANQEKNMKIKPKGLKYRAGKHGNKIIRMRRKRVIALESKNLKISQDPDSKAYSLKCGKYVYSIKAREEALSECPNKFVMQYPCMIKGCSSVVTSENNIIRHYKCHKLSKAFTSQHKHLLVVSNKYSDSAENEASSPKEASSDKNCDLKDLEPQMLEAASADVKFTPPVAQKEPEKDEKDEVDELAELFITKLVNEDLTNAENPAKPSPDVNTSDCQETISSISEKHSVSSNLKRASKEKDPTQKKKKKVEKQEETVTVELNSVHKETETAVAVQTTEDASSAFDWSSFKPMGFEVSFLKFLEESAVKQKKNPERSYNHCGTRRGSHSNSRRSNDRNSFARTRSCSESAAYVQFANPSQFQCSGTVKIVLDKTFRDCTELVLNQLQKMKPIVSLVRLDGHREANAGITK
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MSRRICRCAGRKSEAAISVMSANVAVPSGHERAAGGTTRITSLALSAAIAEERLSMTGNDKASSPPTVAERSSSAAIAVDHLVKVYKQTRAVDDISFSLPRGSITGLLGGNGAGKTTTIAMIMGLVLPTSGRVQVLGHKMPEESASVLGRMNFESPYVDMPMRLTVRQNLTIFGKLYAVKNLAGRIARLADDLDLTEFIDRANGKLSAGQKTRVALAKALINQPELLLLDEPTASLDPDTADWVRGHLERYRKENNATILLASHNMLEVERLCDRVIIMKRGRIEDDDTPEAIMARYNRTTLEEVFLDVARGRVNGAQEAAR
The following text describes a protein:
Function:
Transcription factor which binds to the cAMP response element (CRE). Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut. Required for the expression of odorant receptors Or43b and Or47b.
Subcellular Localization:
Nucleus.
Sequence:
MFNSNIPASSLLSIDSGGLLMGGHTPKTPEILNSLIAMTNPLENFSYSSAAAAAAAVSVASSSASCSAASTPVVTVRHFNGHPNGQSHSQDSSHSSCSGSPLDSPAGTATTPSVQQTCSRLIKEGLKLSIQSKRKLSTCDSSSGSEQPHSKYSRRSSNHNGHSGSSNNYSGSMSNANDLDDDCEESSDDDSETKSQPKGLTPEDEDRRRRRRERNKIAATKCRMKKRERTQNLIKESEVLDTQNVELKNQVRQLETERQKLVDMLKSHGCQRAGGCQLPSQLLQSPAQKYLSELELETVSIDGPNSGNNNQRLQSIPSMATFKYGSKTAAAMAQQLPNGYCKPSPSAQEFEHAGYQQQQQQQQQQQPQSLNPAGNNVIDQQHANPSPSLLSDYVPNCDGLTGSASNHPSHNNNNNNNNSSGASSNTSNNNSNISSHSSNATSSTTPTATSSAIEFVKNELVDSQSPYTTALSAERFLFEPSDGFPDIKHACVLPSPCGINGLNMASVVNTNGSTGNNNNSHHNNNNNNNNHLMDFHQGLQHGNIGTGVGVGVGVGVGVGVGVGVMTPYDDEQLLLLKNGCFATDLLSQLVEEGGEYVDLDSATAFMNNGSCLA
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for ATG9 anterograde transport from the mitochondria to the PAS. Also recruits the ATG19-prAPE1 complex to the PAS. Required for the Cvt vesicles completion. Plays a significant role in life span extension.
Miscellaneous:
MISCELLANEOUS: Present with 86 molecules/cell in log phase SD medium.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole. ATG11 localization is dependent on ATG11-ATG30 interaction.
Sequence:
MADADEYSTAPTQQEITPLQTTATIINAISGECITTNVDFFVSLDKFKQFIARKWKIPPDQLLILLPYGNKLKPSMFKELLINRSFTLNDFYVYDRRLFSLVSKPTPTNLLTSKDSNPMNSPNSNDLTETLEYLIKNSHISQYQGSDTIMIKPMPSPLEDADVDLSRLNYHSVTSLLTTNLGWLSALEIDVHYFKSLIPDIIAHIKRIFDGLTVCSQYLKLYCFDVESLYNSNVQFLNQLVDNGMTSKWEKCFNDTLSKLTALEGDSLQKFINIESLLENEKSVKILNHSINGKLNKIKREIDENASFRDIITVNIDRLRQMFTPNESKFELEDQMAESFEVLVSEMRTRSRNVLDKEEEEFNSQEFLKSMNVMLEKDKKESVKTLFTISQALYSQIGELIDLKKSLQKHAVAILGNIAFTQMEILGIKRLLLNECNKDLELYKKYEVEFAQVEDLPLIYGLYLIEKYRRLSWFQQILSFISNFNQDLELFKQNELRTRNKWVKNFGSIATVFCEDLLSSSDFKRLNEYHSHTSPPNEDEEDENENSIANYRQDLVKVSQAIDNYMTQIKETDVSEPIIDLLSKTLFETKRFHIIYSNFKNNNNNSSNGNSISPEGSIALKSDDVVKGYKTRIKKLESLLHEFQYSDIGHWPQGVLNTHLKPFRGSATSINKKKFLGASVLLEPANISEVNIDSVSQANNHQIQELESNVDDLLHQLQLLKEENNRKSMQISEMGKKISDLEVEKTAYRETLTNLNQELARLTNEEQSHRTEIFTLNASFKKQLNDIISQDNEKIEKLTGDYDDVSKSRERLQMDLDESNKKHEQEVNLLKADIERLGKQIVTSEKSYAETNSSSMEKGEKFETIPLAEDPGRENQISAYTQTLQDRIFDIISTNIFILENIGLLLTFDNNNNIQIRRVKGLKKGTAQSNILDESTQMLDAHDNSLIKSPVFQKLKDEYELIKSVANGSEKDTQQSIFLGNITQLYDNKLYEVAVIRRFKDIETLAKKLTKENKIKRTLLERFQREKVTLRNFQIGDLALFLPTRENVNSVGSMSSSTSSLSSSFSSVDLSTPPPLDAMSIQSSPSVIHSNVINQASISGRDKNKLMRPWAAFTAFEESTRYFLKDEKGLTKGKEWFVGRIVTLEHFVADSPSNNPFRLPKGSVWFQVTAVVVSYQGV
The following text describes a protein:
Function:
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions. Also shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis-pNPP).
Subcellular Localization:
Cytoplasm.
Sequence:
MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPLMKQGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPKTCVDLWIGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDDRAVNYLFKTPGGSLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADMLRMGEALNAKVVIPFHHDIWSNFQADPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL
The following text describes a protein:
Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
Subcellular Localization:
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus.
Sequence:
MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQ
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of UMP to UDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKRREPDMFKRVLLKLSGEFLAGDNGFGISPETTAELARRIIGALDGTEVELAVVIGGGNLWRGARNGQGMDPATADYIGMLGTVMNAMALQDAMEAAGKPTRIMSAIHMQQVAEPYIRRRAMRHLEKGRVVIFGGGNGAPFFTTDTTSTLRALEIGADVVLMAKNAVDGVYDSDPRKNPDAKRYEQLTHMDVVEQRLEVMDATALTLCMDKGLPIVVFDIFEEGNLARLLRGERVGTLIQSRG
The following text describes a protein:
Function:
Involved in magnetite crystal maturation, but not in magnetosome vesicle tubulation or formation. One of 7 genes (mamLQBIEMO) able to induce magnetosome membrane biogenesis; coexpression of mamLQRBIEMO in a deletion of the 17 gene mamAB operon restores magnetosome vesicle formation but not magnetite biosynthesis.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Magnetosome membrane; Single-pass membrane protein. Note=Tagged protein forms chains, aligned patches but also unaligned patches in the cell; the chains and aligned patches are in the correct position to be magnetosomes.
Sequence:
MVRVIGSLVFGGLILLLASSNAHMVETRFGPLIMLAPHFVVLGITFFLGFAIGIVLVFANVMKRRKHKLPGKNIVIKR
The following text describes a protein:
Function:
Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQRALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWMNDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVTRDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTRLREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSNAVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSGNLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTWRTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGLKTAIAAVRGRRRSKRMAKSVTEPDDLAA
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAQFDQYTWIFAISTVVSFICAFGIGANDVANSFATSVGSKALSMPQAIMIAAVCEFLGALLLGAGVTDTVKNKIANVGLFTNTPELLMMGMLAVMIMAAFWDNFACHLELPVSTTHTTVGAIVGMAWVIRGRYAVVWSKLNINPATGDNDFPAGNNEFPYLKGMSIIFLQWVVSPISSGILVSILFFLLRTFVLRSPHSFIRAFYLFPILVTGTFFVVVMFVIQTGNKNGSWDLSGAESVWISVVIAVGMGVLIGLIAMPLLWKAVHAADADRERSEADRKMEAAKIEACELDPKEAARLRALADVEAANESKDTMWNRSMDKMGVNKFAQTGAGKLIFGNWFVRTLTYGANYKVHDAIGTDDRVGEIWEGAEVFDFKTERLFRYLQVFSAMVMSFAHGSNDVANAMGPYSAVYTIWNTSKVPPKTNVEKWILVYGGAGIVAGLSTYGYKILQVLGVKSVKMTNARGFCCELATAGVVILSSRYGLPVSTTQTITGALVAMGLFEGAKGVNWRVITKVFGGWILTIFIAALISAAITSFAVYSPSKVASDDNNYVATYIDNQALRMIRQMNTSANGLTVRPALNNLSKTVNAIVKSANKHPYDYVKAHNSTFVLYNSTLASKAV
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
Domain:
Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.
Sequence:
MKKTISQIVSERILILDGAMGTMIQQYNLKEEDFRGERFAHIPGQLKGNNDLLCLTRPDVIQDIHRKYLEAGADIIETNTFSSTTVSMADYHVEEYVREINLAATRLARELADEYTAKSPDKPRFVAGSVGPTNKTCSMSPDVNNPAFRALSYDELAASYQQQMEAMLEGGVDAILIETIFDTLNAKAAIFAAGQAMKVTGIEVPVMLSVTVSDIGGRTLSGQTLEAFLASVQHANIFSVGLNCSFGARQLKPFLEQLASRAPYYISAYPNAGLPNSLGKYDQTPADMAHEVKEYIQEGLVNIIGGCCGTTDAYIAEYQTLIAGAKPHVPAPKPDCMWLSGLELLEVKPEINFVNIGERCNVAGSRKFLRLVNEKKYDEALSIARQQVEDGALVIDVNMDDGLLDARTEMTTFLNLIMSEPEIARVPVMIDSSKWEVIEAGLKCLQGKSIVNSISLKEGEEVFLEHARIIKQYGAATVVMAFDEKGQADTAARKIEVCERAYRLLVDKVGFNPHDIIFDPNVLAVATGIEEHNNYAVDFIEATGWIRKNLPGAHVSGGVSNLSFSFRGNNYIREAMHAVFLYHAIQQGMDMGIVNPGTSVLYSDIPADTLEKIEDVVLNRRPDAAERLIELAEALKETMGGTSGQAAVKQDAWREESVQERLKYALMKGIGDYLEQDLAEALPLYDKAVDVIEGPLMDGMNYVGELFGAGKMFLPQVVKTARTMKKAVAILQPIIESEKVEGSSSAGKVLLATVKGDVHDIGKNIVAVVMACNGYDIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMTHVAAELEKAGLDIPLLIGGATTSKMHTALKIAPVYHAPVVHLKDASQNASVASRLLNSQMKAELINELDAEYQALREKSGLLRRETVSLEEAQKNKLNLF
The following text describes a protein:
Function:
Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the NADPH-dependent reduction of beta-ketoacyl derivatives, the second step of the FAS-II elongation cycle.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MTDTATENTTESAADYGRPAFVSRSVLVTGGNRGIGLAIAQRLAAEAHKVAVTHRGSGAPDGLFGVECDVTDNDAVDRAFTEVEEHQGPVEVLVSNAGISKDAFLIRMTEERFTEVINANLTGAFRVTQRAARSMQKKRFGRIIYIGSVSGMWGIGNQANYAAAKAGLIGMARSISRELSKAGVTANVVAPGYIDTEMTRALDERIQAGALEFIPAKRVGTAAEVPGAVSFLASEDASYIAGAVIPVDGGMGMGH
The following text describes a protein:
Function:
Involved in positive regulation of the levanase operon which comprises the levDEFG genes for a fructose PTS system, and sacA for levanase.
Domain:
The PTS EIIA type-4 domain may serve a regulatory function, through its phosphorylation activity.
Sequence:
MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSNVSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQNHQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQFAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGGILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKTFLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFGNVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEYVNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLHVRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFLKRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSIKSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEKMKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLNLHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTPIHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAITKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFNNAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRISDDEKLFIAAIFAEEVHGQLF