lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Subcellular Localization:
Nucleus.
Sequence:
MPATEASPVVCSESAIVKMEDRKRPATHDHNDSAPPLKKQATSVNGGSKPHPDADMPWKDDLERFQKDAIWRQMQEYKREKMSLETKLKEMSKATAYHNDHLRVIDAWFNQLIDEVKTLMGALDEDKDRPSFRSSLLFENMEDFEKHLKARSDDIRAIITRLQSFSINAPPEVTDLQSQLAKKLAEEKGTIAELEKALAEKQQLEESLEAASLRYMVAEKKLDRARSLTVAKLEKQYLLGAQRPGGDSASGNREEQSPVNGLPSSAERNTELEEAHKQLVAVSEKQKEQLQKLESENANLLSQITELNIKRTKPTDDDYAHTDLFKQLRSQYDDVVKRINHLEATNIQLREEAAKLRSERTAYRNQVDEETQNVIAEKEAQLMRAETDLARIRNARDELLADQQMRKAAQEQEKIATTKVQELADAAQARINALESEVDRLRLQLDNTKAAHTEIDDVPLEELRAKYQNLERQYSMLNTELTSMQTACKKYSLLASQKVADFSALEEKVARLTAEKSKADQKYFAAMKSKEARELEVRTLRIQNSKSSDIVSQLKESEATTRSLLANMEKQASETKEALNSIISKHHAAQQQIAENNIVIDGLKAQVNELKALSVSKDSSLASASSACRKAETEIESLKVTLADTKKSLENWKNKSLGNSSSEYEMLRSLALCTVCRRNFKNTAIKTCGHVFCKECVEERLTSRSRKCPNCNRSFGNNDHMHITL
The following text describes a protein:
Function:
Required for promoter sequence element PCB-driven, M-phase-specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Binds, cooperatively with mcm1, the CLB cluster regulatory elements throughout the cell cycle. Regulates the periodic transcription of cdc15 and spo12. Required for the correct timing, positioning and contraction of the division septum.
Subcellular Localization:
Nucleus.
Sequence:
MTVRRLESKSEHISDDEERKEQLDYKKQMDVDTDRNIVLNGRLESQIAKLSVPPHEMRVVDDYSNSKNAERHSGEIQAYAKFAGSTWTYYVKKIRIILGREPANPSPKGKNEDLEVIDMNFGPSKVVSRKHAVVEYDLDDQTWNCSVYGRNGIKVDGKLFKNGETVKLTSGSILEVAGLQMMFVLPNAAEQKQTDESTIKEDAIKSEISAAVNDAAEYGDNKKPPYSYSVMIAQAILSSSECMMTLSNIYSWISTHYPYYRTTKSGWQNSIRHNLSLNKAFRKVPRKSGEQGKGMKWSIVPEFREEFIAKTRKTPRKRSPSSPVPLLAKKREGSPSLPIPILPKMKDTSIPAAEPASSTTSARDQTPSTPKDVGSPSTAETSAEEKQMETYKTPTHAALSDIISTHDYALDANSASQTKKAAFGSPIGSSTYPTSSPAPFWKYVAVPNPHDWPQVGSYDTISPYRNPVNSHLIYSQIQQSSPKKIDEQLHDLQGVDLVNGFEGISSWRESMVNKLRSSVSDSPTMNLANSNSKSSPVAVQRVSTLPQASANKQAKEMESKMSNSPTQKSKTEENNQAVRAILDASATMEKQYDLHRLPTPTSQTESASVPQIANPPNSQNLVKEKSPQQYIQVPQSNVKSSA
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MATWEEYLATQQANDGVQFTWNMWPHSRVDAQRLVVPLTCFFTPLKERPTTEVAQPPLEYDPVLCQKASCKAILNPLCAVDYRAKLWMCPFCNNRNPFPAHYAAIAEDNRPPELYPQFTTIEYTLRKATTMPPIFVFVVDTCMTAEELKSLKECLQTALSLLPADALVGLITFGRMVQLHELNTQGISRSYVFKGTKEVTAKQIKDVLASGMARPTAPGAPAGGAPGAPMAGGAPHGATGPMGASRGPMGPPGAPGAPGAPGQAAPAHHAPANKFLQPISECDDSINDLIDQITVDRWPVPQGHRPLRATGAALAVAVTLLESCFPSTGGRIMSFIGGACTHGPGAVVGEELKNPIRSWNSIKEDNAPFMKKANKFYDGLAARVVKNGHAVDVYSCALDQTGLLEMKNMFNSSGGHVVMGDSFNSSLFKQTYQRSFDKDAAGNLKMGFNATMEVKVGAGLKIEGVLGCCASGNVRNANVSDQEMGIGGTCQWKFGAISPRTTIGVVFEIAAQHGSAIPQGGRGMVQFVTQYQHADGRKRIRVTTTCRTWADMGTQQPNIAYGFDQEAGAVAIARLASFRASNENDTPEALRWLDRSLIRLCQKFGEYSKDDPNSFRLSDKFSLFPQFMFHLRRSQFLQVFNNSPDETAYYRHILFSENVLESTTMIQPVLFSYSFNGPPEPVLLDTSSILPDRILLMDDYFHVLIYHGQTIAQWRKQNFHENPQYASFKQLLEAPVADATSILQERFPMPRYIVTEHEGSQARFLLSKVNPSLTHNNPYANEAGAAVFTDDVSLQVFMEHLKKLASSSTT
The following text describes a protein:
Function:
Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.
Sequence:
MTSSISESNYPLSPRDAVASQYIGQRFEDLPTPAIVLDKSKIKKNCAAMLQVCQQLGVGFRAHVKSHKTLSLSRLQVGETGPANFIVSTVIEAENLFDYVLECQKKGREASILYGIPVPQSSIPRLVALASALAPGSINIIIDNIDAFNLFQAAISQSNVQIGIFIKIDTGYHRAGIVTSSPKFPTLVNAVSSNTHGAFLKGFYSHYGHSYAGNSQDDAATGLIEELLGLEDACSALPPTFSGKLVLSVGATPTATAAQNMLSSSSPRVTEFHSVLARLKTIRMLLEVTSVYTERSKPEALVSAGSLALGREPCKSYPGWGIVTPDFANTGAQIYEETGEKTGWIVGRISQEHGILVWEGDVGKCKDLKVGDKVMLWPNHACVAGAGFGWYLVVDSEDASGGTKVVDVWGRWRGW
The following text describes a protein:
Function:
Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.
Subcellular Localization:
Cell surface. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MIWKNLFVEFLLITANVLFCCGEMLNNGSKAKATQPFNSLLFLSNHLFTTPPQSKVEASFTRFVHGIAQPANQEAYSIQKEKVITDKPMPSSADKITDHTQEKTTVDPKMMSAKPTGQHIVYTVVKTTDVARGAGRQTEPLLDRIRSHTENRKTLATEMTTLQAGSPKVQKTATLIQPVVMANTNKTVSETGHIYTTQSATKRTTGIVHKNITSVVSTAPKPTTPVGPTLAPKLSPAATGTYRVLNGTANCIKALMGLTLIAKNRNTNQMEYFNIDPNATQTTGICGALLSVLKISFQDGFISFTFHKNGEEYYVSLVEATLTVPSEGVPYVGMKSDKLFSVQVGNCFKCASPQTLDMSEDLQLLVENSQLQAFDDIGDTFGTAEMCALDRNKKLIPITVTLSLVGLFIIVLVTCVIYRRKPISGYESI
The following text describes a protein:
Function:
Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Plays a role in the complex assembly and recruits XcpY resulting in a stable complex in the inner membrane. Provides thus a link between the energy-providing XcpR protein in the cytoplasm and the rest of the T2SS machinery.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Domain:
Two distinct periplasmic domains, one located in the proximity of the transmembrane domain and the other located towards the C-terminal part of the protein are both involved in the interaction with XcpY.
Sequence:
MKVMTQFHERLRAQAETSQLAIRWRGLPARDRLALLWLGAFLLLVVLYLALWRPAERHLQSARQYFTEQRALHAYIQQQAPNVRQADAAAPQAQIDPAALQGMVTASAAQAGLSVERLDNEGEGAVQVALQPAPFAKLLPWLEQLNGQGVQVAEAGLDRQVDGRVSARLSLRVE
The following text describes a protein:
Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MARSRRDKNVSLTKVKKKTKDTKNSLVNEVRASVDQYKNLFIFTIANMRSTRFIAIRQKYKESSRFFFGKNNVIAIALGKQKSDEYANQLHKASAILKGQCGLMFTNMSKKEVETEFAKISEEDYARVGDLATETVVLPEGPIAQFAFSMEPQLRKLGLPTKLDKGIITLYQEFEVCKEGQPLTVEQAKILKHFEIKMAQFRLIFKAMWNKKDGFKELEA
The following text describes a protein:
Function:
Insecticidal, cytolytic and antimicrobial peptide. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis (By similarity).
Subcellular Localization:
Secreted.
Domain:
Both the N-terminus (61-94) and the C-terminus (99-129) of the mature peptide form alpha-helices which probably disrupt target cell membranes. The linker region (95-98) probably derives from a processing quadruplet motif (PQM), found in propeptides of many zodatoxins, hinting at a fusion of two originally separate membrane-active peptides.
Sequence:
MKYFVVALALVAAFACIAESKPAESEHELAEVEEENELADLEDAVWLEHLADLSDLEEARGFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYVLKYYGKKALQKASEKL
The following text describes a protein:
Function:
Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels. Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa). Plays an important role in homeostasis of aromatic amino acids.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MGPDDAPTPGPDPHPPPHQQRDERRDERRDEREEQREPAVPGAGSGSGSGSGPEEAARAEQGPAEGPAEGPAEGPEPPEGGWGWLVMLAAMWCNGTVFGIQNSNGVLYVSMLETFQDDDDGSLTFRAALVGSLSMGMIFFCCPIVSVFTDLFGCRKTAIVGAAVGFIGLFSSSFVSSVEPMYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLKILIAKLKLYATFRVLSVFMFILILAGFTYKPLVSDAKDKVKNSGKKGSRFSFFSRKQSTPAKKIFNFSIFKVPAYVVWSLGIPIALFGYFVPYVHLMNYVKERFETETNKEVLLMCIGITSGVGRLIFGRIVDYVPGVKKVYLQVISFFFIGLMSMMIPLSQVFEALIGVCLFMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGFLREKTGSYDVAFYLAGVPPIIGGIVLCFVPWIHERKKASNGKKMEKMLDNQSTLLPSFSEVIKRESDSVI
The following text describes a protein:
Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation.
Subcellular Localization:
Cytoplasm. Cell tip.
Sequence:
MKGLRSKFVKALSLKDEQGSHKNGHSKSHYISKNGSYVETDDVKHTDTHHSSKHELKKLKSHFLKDTLKHKRNHHANSNNEKHENSDKKIHTTVLASGHEDSDYSTFLPVIETSKVKDANHFPPNYPEPKNDSVSSNIDEFPNDSISSASFLSVPQSTPPYLVSQPTPLNKFLAGAENVDIPHSLRPVPRREHSSQFQVSEKRTLVRLPSFDDVHTSEREELFIKKLEQCNIIFDFNDPSSDLASKEIKREALLQMIDYVSENRGISSASLFPYVVNTFSLNVFRPISPALNDYSSDMFALDDEPFLEPAWPHLEEVYLLFIKFLESPDFRASKAKSLVDRRFFNRLLALFDTEDPRERELLKTTLHRIYGKFLNLRSYIRKSMNNVFLQFIYEREKFHGIAELLEILGSIINGFAVPLKEEHKIFLSKVLIPLHQTKSVFLYHPQLTYCIVQFIDKDPSLTKAVLTGILKYWPRINSFKELLFLNEIEDIFEVLEPSEFVNIMSPLFQQLARSISSMHFQVAERALCLWSNEYFTSLVSQNVVTLLPIIYPSLYKTANEHWNSTIQAIACNVLQIFVDMDADFFNGLVEDYKQAIIKQEEVMIIRKQQWCQIEALAAENKPTDYLR
The following text describes a protein:
Function:
Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. Cannot reduce phosphatidycholine hydroperoxide.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MTLSSLEKIDIRMNQLQAKYAHQGNGFAVLAFPCNQFGHQENLNGEEILHSLKHVRPGGGYQPDCVVMDKCDVNGSNAHPLFQFLKESLPTPSDDADSLMSDPKFIIWKPVKRSDISWNFEKFLITADGKPYKRYSRNFRTEAIANDIEHLLSVASKKGRK
The following text describes a protein:
Function:
Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASVEMWYSSPWTKSLPMRVKTKLGLPLKEKKLMEVKLGELPSWILMRDFTPKGIAGAFQRGYYRYYNKYINVKKGSVAGISMVLAAYVLFNYCRSYKELKHERRRKYH
The following text describes a protein:
Function:
Required for efficient sporulation target of PtdIns(3)P in vesicle transport required for onset of the forespore membrane formation; Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor pep1/vps10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection.
Subcellular Localization:
Cytoplasm. Golgi apparatus. Membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Sequence:
MLGHNIYEEDDAFNPFADSVSPLNPPKTDQEPSAEGVEEESPNVQASPPKTHIYTSPRKRSVNLKSLPFETLTLDSAPLGPLQFSDAPSMAPENNRLEVGLNTKINPLKGSSPALNADFSANKPWISEVNSFSPSPIGATENPTIPNSEQTVDTLDAASSSAPNFTHTVSSASSQKQGSTSLTDTENQKAHPAAAPQSLTPFYIQVHDPHTVKEITKSHTVYSVSTRLEEHNQPSVSNVTVQRRYNDFAFLYQLLSNNHPGCIIPPIPEKQVVGRFDDEFIEQRRAALEVMLRKISAHPVLRDDYSFKLFLEAETFDPRMTHRTTLIESSSSPLRSGPSTSGLLDSFTSAFHTSGSSKFSEQDPILIEAKDTLDSLETQLKSVYHALLLSIDQRIQFASAIHDFGEAVGNLSLVDLEPTLSSKFDGLSQLQVELRFVQERKVAQDNLTLGTTLEEYIRYVESAKNAFTTRQKLWQTWQSSVQAVSRAKTQLEKCKKQAKSQQKSLPYLEEQYEKYRAKAADLEKEFSESTTLLKRDLSSLTTSRVDDLKASVETWLESAIESQKEIIERWESFLDQ
The following text describes a protein:
Function:
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNTTNLEFEICGALVEVKCLNFRKLQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIVKPEAPFDLSVIYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWMRVNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSYYFRTPEINNSSGEMDPILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFLQQLEESEKQRLGGDVQSPTCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ
The following text describes a protein:
Function:
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.
Sequence:
MKLLLFGYGNVGKAFRKLLHEKRSPELNDVIIGGIVTRRGIMLQDKEDFTPDLEGDVFKAFEKIKPDIIVDVSSANYNNGEPSLSLYKEAIKDGVNIITTNKAPLALAFNEIFSLARSKGVKIGFQGTVMSGTPSINLYRVLPGSRVIKIRGILNGTTNFILTLMNKGVSFEEALKEAQRRGYAEEDPTLDINGFDAAAKITILANFMIGNSVTIKDVKFEGINRDLPKNEKIKLIAYADEKEVWVKPLPISQDDPLYNVDGVENALEITTDIQSILIRGPGAGPVNAAYGALSDLILLKRDCL
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Sequence:
MDCYTANWNPLGEEAFYRKFELYTMEWGLKEDLRDCLVAAAPYGGPIALLKNNARKEKSPSTRPLLEIYSASGLLLASIPWKSGQLVQLGWTASEDLLCIQEDGTVLIYNLFCEFKRHFSMGNEVLQNHVLEAKVFHTEYGTGVAILTGAHRFSLTTNIDDLKLRRMPEVPGLQKPPSCWAVLTQDRVTIVLLAVGQDLYLLDNTSCSVVTPPGMSPSAGAYLQMAVSFNYRCLALFTDTGYIWMGLATLKDKLCEFNSTIRSPPKQMVWCTRPRSRQRAVVVAWDRQLMVAGDSTECIRAGLQPPATFFPRALSGRHRFVLDEDSYLVPEPDGVRILSRTSHEFLHEIPEASQEIFKIASMAPGALLLEAQKEYEKESQKADEYLREIKDQKLLPEAVSQCIEAAGYEHEPETQKSLLRAASFGKCFIDKFPPESFVRMCQDLRVLNSIRDYQIGIPLTFTQYKRLTVEVLLDRLVLRRLYPLAIRICEYLRLPEIQGVSRILAHWACYKVQQKDKSDEEVAYAINQKLGDTPGISYSEIAARAYDCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVYTVVLHLKNELNRGTFFMTLQNQPVALSLYRQFCKHQERETLKDLYNQDDNHQELGNFHVHSSYSEKRIEGRVGALQNAVDEYYKAKNEFAAKATEDQIKLLRLQRHLQEDFDKPYLDLSLHNTVSTLIQDGHHKKAEQLYRDFKIPDKRYWWLKISALATRGDWEEMEKFSKSKKSPIGYLPFVEIAVKHHNRYEAKKYAPRVTPEQRVKAFILVGDLEQAADAAIEHKNEAEMNLVLSKCSAATDSAVMEKLNRARAQLLKK
The following text describes a protein:
Function:
Dephosphorylates the phosphotyrosine-containing proteins.
Sequence:
MKILFVCTGNTCRSPLAESIAKEVMPNHQFESRGIFAVNNQGVSNYVEDLVEEHHLAETTLSQQFTEADLKADIILTMSYSHKELIEAHFGLQNHVFTLHEYVKEAGEVIDPYGGTKEMYVHTYEELVSLILKLKDIIC
The following text describes a protein:
Function:
The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress.
Sequence:
MKQKDLKRAYNNVLAQAISGSKQYLFAGNLFGDIFVLRIKELDKGSEEPPGKLKIFPQGSDVDINYLAFHRDFLIVGAVGLIYGLEWNEEEESLATKRSWEVKIPMQVDAVEVPDVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQIFSGAEDGTVRVWSTKQQQHTSMLEPYKNPNLLRPDWGKWIGAVAVNEDWLLCGGGPKASIFHLRSMESTCVFSFPGRVHLCDFVDDCVLIGGEHNHVQSYTLNGVLQANIPVEHTACYSAVWQTSPIKFISIAGFSNKLHILKDFRFLDSKIEMYGNVEGEENDPEEEDELIEKPLTVEAA
The following text describes a protein:
Function:
E3 UFM1-protein ligase that mediates ufmylation of target proteins.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
VADLLRRMAISSPKMFVPSGVEIDVSQLCFNKAHFTRSDFEVQRFMTLARRRSDLKTIHSDLRLYLKSIQHSMVELINEDYAHFVNLSSNLVGLKTSIDSINTNIDTVWKDFNETAKDAVTQAEKIELRCTQLTATRDAQQKLSRQITAISSMKKLRSTLREASTPLTTLFLERLTSLLTDLVVNKEAIEEDSAAMKAYAKVMDNVGDRLNTEFLSSLQSDLSLLPLIFSLLSLCRLSDRLVSRIVSDVIDPSIKKEQNKTPLHSLNLVLESISKLRSDWSSKLGSHSKGPLMDFLDQSLLTFLLSYIDKSLSMHLTTSPSLFHSAFQSISIFIAEWPSQSASSPHLRAIRSRFQLQVYFLQVASAPWKKLQELADPSKFSLAEGEQEDEETRLNSQFFFQAAETIKGLWHEDRFLLPLAGKCWEQTTKIILLCVNYAKAMIDSVTSSDSSSPSFLSTLCSLQVDCTRMGAIVFDHALLSIWPRLRELGVDTSTFGQTLNAFIASMKKEAERVRSSMVDSLTRELDTMMNGVSQLPKQYRWTKKPSPTSASSYISSVVSRVDEAVKEAKEKGVEGAEEMGREAIERSAQGLIVKAQQVLETVNATGVSLSRLKRREGAAGSGEGETDEEKIRMQMGLDLSSILERIRGNEERTKEMEELLSKVQSTMTTWADIQRLATDLQRVQLANAAQKLSESNCIEVVTRLIERGVIDVVYTRDGSAYITRNHLCTMIVNEVSAAGGRLGVEAISANLNVHFDHVESSIPKINEEHGEYLYTNGELISREYVNQLHSQLRSLLSDCGLRTIAFLARHWDLASDTLLQLLTPLPQELGAVLDGDQIYTHSYMAAHKNGVRALFAATTKMTLLSTLITRSNLPSPRFHSLLDELIAEKEIAGRFSGSRHSPSALYVPNLHDRLVEAYVKNQIMQKEYIDLSMFRKLSLGEPKAALVQILGGVEKVKDLHILSTIVCTEAVLQRVKTILNDELSSKGVSDVFAVQTEIEIPFGVEDIQSIMKEMAKKDKKLTVEGDLIFSSSMISSALNEVKTSDRLNEKAREWVEKKLEKRGKEKKEEKESTPQPQGKKGNATAVVEDDDDWDDKKKGKGKKGGRGGGGEKGGTKGGGKPVNVTHKDKEREEERASMPHVSVDELEEWLVSVPEQLRAIVAEKIHYEVDSCLSLLTQQQLASREQEAVQSTKKAHGQMREKAIALYQRIRVFEEATHSELFEISLKSDLRSHLLKTLCSELSNDLLAFVSSSPSGITLTPKVCSRSICDLPLNPIDKDTRDSIISSYTSLLKEEAASSVPAATLLSLILLQFTKQGVAVHASGKFVSQLLPCLKSKLDESSFDSMIDTQKLVIDSMRKKGAELEEINQSLNEKINGLREKYLK
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MHAVPSSKPGPKKARKPKPKPEPESDEDFSNEEDLEFSDGDHDISDLLESDEGEPEPEAPKRALGDQASTQPRKKSKTAKSDLYKPPTAEELNNLKEVETLFHSNLFGLQLSDLLKEVALKEKHVHQFDAWLGLFRKALLALPAWDKARENPEESLKKAVLPLLGRSPRDPRCRFRFAPPRSVRLVGSHAFQGALGPDATADVALEMPQECFEKTDFLNRRYHVKRALFLSVLASHLRKSELVEEMKFGWHRGNTATPTLLLRPSGNAGKHFRVCLLPYPCPEQFKETRFVPVRSNLRASWFYATSAGDKSAADELPSPRYNASVLSDMKMVANAEFLAEKLADASAAVEAILLLKVWLKKRQLDQGPGAFSGFLMAMYVVHLLQQRQISAMMSSYQIARFVLLTLDHCYALVDRGPPADSPDAPAFRAFWGDRSELRRFQDGSILEAVVWPAKNAQERRGLVLDISRHILARHAGLNGLTTVGDFLDPLLQLPTVEFPSATPYGTGEEVTTELVAAYDDLARVLRRLHDLPLTVSSVRGTSPTLRSTEVFPPLVGALGTDYGAYFTTDDGFLCPLPFKAHVPHLVPLTRVVVHMEATGKWPDDLEALRRVKAAFHVTLAKMLRENAKLVTTAHPEHVDVLKDGFVFRLRIAAHKEIGLARQSVGPNGAIAIKDTDLSRKIEFETEILPSLTSTLHGLQQQHSTFSAACRLAKRWVASQLLSGHMTEECIELLVASVYVAPAPYAVPNHLSAPFIFIFFSLPTSEDEEADIHSTFVGQRSTLPPMFLATPLDGQQRSRWTEHAPTGQILHRLVALARESLRVLEGQVACPLEADVRQIFRPPLDPYDVIIHLDERRLPTAHLAVDCSHRTTLKRRKDDCMPVVDFDIAALYVQALQETYGDLALFFYDRYGGNLVAVLWKPHAFQPLPFKVSQIGGRTLNAEGKMVPNVEAVLEDFSTLGKGLVTSVETRTSKWTV
The following text describes a protein:
Function:
Involved in a zinc uptake transport system.
Sequence:
MKKIIEVNNVSYHYDKEHALENIHFQVAKGSFTGLIGPNGSGKSTMLKLILGVLKKQQGSISLFGEKQADFKDWVKIGFVSQKSNAFNSAFPATVKEVVASGLTKKKGLFKTLNNKDKEDIDYALKRVEMTDYLHRNIGELSGGQQQRVFIARALVSRPELLILDEPTVGVDVENVKAFYELLAELNRTEEMTLLLVTHDLMAVNTYVNHVISINKRIIFDGSAHEYQHYLADRELEILAEQRRREDACLDCDASPV
The following text describes a protein:
Function:
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3-deoxy-L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) are also reasonably good substrates, although 2-keto-3-deoxy-L-rhamnonate is likely to be the physiological substrate. In vitro, can catalyze the aldolisation reaction between hydroxypyruvate (HPA) or pyruvate (PA) and D-glyceraldehyde (D-GA) (Ref.6). The condensation of hydroxypyruvate and D-glyceraldehyde produces (3R,4S,5R)-3,4,5,6-tetrahydroxy-2-oxohexanoate as the major product, 2-dehydro-D-gluconate and 2-dehydro-D-galactonate (Ref.6). The condensation of pyruvate and D-glyceraldehyde produces 2-dehydro-3-deoxy-L-galactonate as the major product and 2-dehydro-3-deoxy-D-gluconate (Ref.6).
Sequence:
MNALLSNPFKERLRKGEVQIGLWLSSTTAYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAVAPYASQPVIRPVEGSKPLIKQVLDIGAQTLLIPMVDTAEQARQVVSATRYPPYGERGVGASVARAARWGRIENYMAQVNDSLCLLVQVESKTALDNLDEILDVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIETSIRRIRAAGKAAGFLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALDQRLAMFKSGKNGPRIKGSY
The following text describes a protein:
Function:
Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment oflate-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III.
Miscellaneous:
MISCELLANEOUS: Present with 1890 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosomal and other punctate structures.
Sequence:
MDYIKKAIWGPDPKEQQRRIRSVLRKNGRNIEKSLRELTVLQNKTQQLIKKSAKKNDVRTVRLYAKELYQINKQYDRMYTSRAQLDSVRMKIDEAIRMNTLSNQMADSAGLMREVNSLVRLPQLRNTMIELEKELMKSGIISEMVDDTMESVGDVGEEMDEAVDEEVNKIVEQYTNEKFKNVDQVPTVELAANEEEQEIPDEKVDEEADRMVNEMRERLRALQN
The following text describes a protein:
Function:
Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MARASLVQPALWALLLLQVVGPAAAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWSSTRPEVASIEPLGSSEQQCSQKAVVQARLTQPARLTSIIFAEDITTGQVLRCDAIVDLIHGIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFDWTIVKDTEANGFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLLVGTSIHYKVQKIRQGKITELSMPSDQYELQLQNSIPDPQGDPARPVAILTQDTSRVTAMQMGQSNLVLGHRSIRMQGASRLPNSTIYVVEAGYLGFTVYPGDRWVLETGHLYAITIEVFDRSSNKVYPSDNIRIEAVLPAEFFEVLSSSQNGSYHHIRAIQSGQTAISATLTSVVDQDGGVHVLQVPVWNQQEVDIHIPITLYPSILTFPWQPKTGAYQYTIKAHGGSGNFSWSSSSSMVATVTVKGVMTTSGDTGLSVIRAHDVQNPLHFGEMKVYVIEPSSMEFAPCQVEARVGHTLELPLTISGFMPGGGSEVVTLSDCSHFDLVVEVENQGVFQPLPGRLPPGPEHCSGVKVKADAQGSTTLLVSYTHGHVHLDAKITLAAYLPLKAVDPSSVAVVTLGSSKEMLFEGGPRPWVLEPSKFFRNVTSEDTGSISLSLLGPPASRNYQQHRVLMTCQALGEQVIALSVGNRPSLSNPFPAVEPTVVKSICAPPSRLTLMPVYALPQLDLSCPLLQQNKQVVPVSSHRNPLLDLGAYDQQGRRFDNFSSLSIQWESSRPLLASIELDQPMQLVSQDDGNGQKKLHGLQTVSVHEASGTTAISATATGYQQSHLSEARVKQPHDPLVPVSASIELILVEDVRVSPEEMTIYNHPGVQVELYITEGSGYFFLNTSTQDIIKVAYQDTRGVALVHPLLPGSSTVMVHDLCLAFPAPAKAIIHVSDIQELYVRVVDKVEIGKAVKAYVRVLDFYKKPFLAKYFTFMDLKLQAASQIITLVTLDEALDNYTATFLVHGVAIGQTSLSASVTDKSGQRVSSTPQQIEVFPPFRLIPRKVTLIIGAMMQITSEGGPQPQSNILFSINNESVAAVSSSGLVRGLMVGNGSVLGVVQAVDAETGKVIIVSQDLVEVEVLQLQAVRIRAPITRMRTGTQMPVFVTGITSNQSPFSFGNAVPGLTFHWSVTKRDVLDLRGRHHEVSIRLPPQYNFAMNVYGRVKGRTGLRVVVKALDPTAGQLHGLGKELSDEIQIQVFEKLRLLNPEIEAEQILMSPNSFIKLQTNRDGAAILSYRVLDGPEKAPIVHTDEKGFLVSGSGIGVSTLEVIAQEPFGTNQTILVAVKVSPVSYLRISMSPVLHTQHKEALTALPLGMTVTFIVHFHDSSGDIFHAHNSVLNFATNRDDFVQIGKGATNNTCIIRTVSVGLTLLHVWDVEHLGLSDFVPLPVLQAITPELSGAVVVGDILCLASVLTSLGGVSGTWSSSASHVLYVDPKTGVAIARDAGSVTVYYEIAGQLKTFKEIVVGTPQKIVARRLHSAQTSIQEATASKVTVSVGDRSSNLLGECSPAQREAIEALHPESLISCQLQFKQDVFDFPACDVFTVEPGFDAALGQYLCSVTMRRLTDKQLKHLNMKKTSLAVTASIPSSYTSVEKVGAEVPFSPGLYANQAEILLSNHYTSSEVKVFGAVESLENLEVKSGSPAVLAFVKEKSFGLPSFITYTVGVLDPTAGSQGPLSTALTFSSPATNQAITIPVTVAFVLDRRGPGPYGASLLSHFLDSYQVMFFTFFALLAGTAVTIIAYHTVCAPRELASPLALTPRASPQHSPHYLASSPAAFNTLPSGRKASPPSGLWSPAYASH