lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLRTKNSQIILLSLALHLALILYADHVDSHPERYGGLRYTDVDWRVVTDGARLIFIPTEKEQAKGWLVKKIGLSIGDPYDRATFRYTPLLPLFLSPALIHPLLGKCLLALPSLLIPLLLLTGPDPAPFWPTHLLWTINPFVLSITTRGSPEAAICFLVVTLHYFLRLGSRNEKKGAGETRAAIVLALAVSWKIYPAIYIPAIWKELSARWGWFGMRVWRFGLIVASSFVLINGALWSIWGQPFLDHTYLYHLSRLDHRHNFSPYFYPIYLSFFPSPTASPLPSALLAVIRHPLTSFLPQISLIITTSLSTSSLCFAMFLQTALFVAFNKVCTSQYFTWFLPLLPPVIPQLRLSRQKTAALVVAWILAQGVWLGSAYLLELRAQSVYIFVWAAGLLVFGVSIYLLGNVVDGWEPARTSKTKLE
The following text describes a protein:
Function:
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Miscellaneous:
MISCELLANEOUS: [Isoform IA]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform IC]: Produced by alternative splicing of isoform IA; MISCELLANEOUS: [Isoform IIA]: Produced by alternative promoter usage.
Subcellular Localization:
Nucleus.
Domain:
The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes (By similarity).
Sequence:
MLALEAAQLDGPHLSCLYPEGVFYDLDSCKPFSYPDSDGGLDSTWGWTEAPPAPAIAPYEAFDPATAAFSHSQTVQLCYSHGPNPSTYSPMGTLDPAPSLEAPGPGLQVYPPEDFTSQTLGSLAYAPYPSPVLSEEEDIMLDSPALEVSDSESDEALLAGSEGRGSEAGARKKLRLYQFLLGLLLRGDMRECVWWVEPGAGVFQFSSKHKELLARRWGQQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPASRHV
The following text describes a protein:
Function:
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ.
Sequence:
MANVTVTFTITEFCLHTGISEEELNEIVGLGVVEPREIQETTWVFDDHAAIVVQRAVRLRHELALDWPGIAVALTLMDDIAHLKQENRLLRQRLSRFVAHP
The following text describes a protein:
Function:
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MAATREEHPGACDVLIVYGNDADEWCHYLQSLFHSCYEVQSYQMECGTVISMEKLDLFKHSKCIVILLSSDLVQNFYIPAVLQSLQNVLQPPHKVVKLFCGVSECETYKEFFKDWPQWKHLTYDDDSDAYIAAVMKTISEGDSGCDSVTDAEVEDDRDLSDSCNITMSRQHEKRLGKLVAVQPDRIRCGVQTIVYIILKCKLDSKVKMEVELYSDSCQPVRVQARMRMSTRSQFAHLVKLPPGTVCLRLFSGDLVIVETSISYYTDMEEIGDLLTASANPVEFMCQAFKIVPYSTEALDKILTESLKKNLPACGLHLFGINQLEEENITSQRDEELPTLLHFSAKYGLKKLTALLLTCPGALQAYSVANKHGWYPNNLAEKHGFKDLRQFIDEYVETADMLKSHIKEELMQGKEGDSVYESMAHLSTDLLMKCSLNPGCDEELYESMAGLVPSATEDLYVEMLQSDANNPFPQTTKDYMMRKFLEGVSADVPDPKEDIYHKCEDEEVYHTVEQDNYPQELVNRPPVPVPRPDPSLKQQDKQSYIYKVHHTSSNQSSSSSIYDPFAGMKTPGQRFLITLQEQVKLGMLSVDEAVLRFKEWQLNQKRRSESFRFQQENLQRLRESITRRQVEKQKAGKPGDLEITVPAGHSQNTPNKPECGIYEFSPRKNFIPPSKGIKRGDWKTESASSTASSSSNRSSTRSILSVSSGMDGDNEVTYPFCTFSGLLTLTVFWMGLLLKDYYFELVPYNVQLVCAMLCTLNLISQHRIFSIVEV
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MGLTEGMQLVSSRTEGHISSQVVESRGPEKKAMLEQELSVTPSDKGRCFACHDTSHNLEQCGIKYNHTTVPHQFGYATKYPFTMIQPSEETVEKEKFNHHCVLITSDLSNLDQGILKSELQKFWKLSGDWELRRECSKSFLASFSSEDDVISCLNFPEMEALLDHKEVNLTVTRWQEGDEESLDLIEEWVLVRGVRRIYRNWKDLYQVASAFGVLIDVDEKSLEAGDKEPIRLKIALRSLDGAPFSYYFALGRSSRLVMVTVVQDKAEGMQQQNKESDKEHNKELNDAQSIFLEETECIEESRLAGEIKGNKISAPAATTANTKKTTMDSSKPEEVQPVGRSSTSMIGEEHFEGKRKPPIKHVFKRRGKEQQVTETEDIHIYGSFSGMGLHENLLKGIYQYGLEKPSVVHQRGIVPFCNGQSVIHESLSGTTVTLCTGVLQRLDYRSAECQALIIVPTRDLMYETEKVIDALGQFLGVKPYTCTGGTSFRVDQQTLSSRVQVVIGTPGRILDLLSRDALCKDHIRMLVLDEADELLTGGFKDQTCNIIQYLPAKIQIGLFSAAFSSEALETSHWFMDKHVTVKVPRDEELKDIGIKQFYHKVEKEEKLGKLYVLFDTLTLESTQIVIFANTKQVVKTLIQDIRGKGYTISASHGGMSQLGRDTAIQEFRAGSSRILIATDLRGTNLGQVPIVINYDLPTQLMQYISRVQQQRRYSETESVAINFVTPADERIVSDIQKFCNGQMSKLPSNPTFELLVGYDVQKCS
The following text describes a protein:
Function:
Neural cell adhesion molecule.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLNAAALLLALLCAANAAAAADLADKLRDDSELSQFYSLLESNQIANSTLSLRSCTIFVPTNEAFQRYKSKTAHVLYHITTEAYTQKRLPNTVSSDMAGNPPLYITKNSNGDIFVNNARIIPSLSVETNSDGKRQIMHIIDEVLEPLTVKAGHSDTPNNPNALKFLKNAEEFNVDNIGVRTYRSQVTMAKKESVYDAAGQHTFLVPVDEGFKLSARSSLVDGKVIDGHVIPNTVIFTAAAQHDDPKASAAFEDLLKVTVSFFKQKNGKMYVKSNTIVGDAKHRVGVVLAEIVKANIPVSNGVVHLIHRPLMIIDTTVTQFLQSFKENAENGALRKFYEVIMDNGGAVLDDINSLTEVTILAPSNEAWNSSNINNVLRDRNKMRQILNMHIIKDRLNVDKIRQKNANLIAQVPTVNNNTFLYFNVRGEGSDTVITVEGGGVNATVIQADVAQTNGYVHIIDHVLGVPYTTVLGKLESDPMMSDTYKMGKFSHFNDQLNNTQRRFTYFVPRDKGWQKTELDYPSAHKKLFMADFSYHSKSILERHLAISDKEYTMKDLVKFSQESGSVILPTFRDSLSIRVEEEAGRYVIIWNYKKINVYRPDVECTNGIIHVIDYPLLEEKDVVVAGGSYLPESSICIILANLIMITVAKFLN
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVKLPFQKGKEGKSSNLVKEDEAIERVALDPKDMGRMAILRGVYPKVSPKDKNSPWAYFHKKDLQMINSDPMAWFIRDHANWLKHHEKRYNRKELDQTPEPVAPYDQLIRSRYPTFADAIKDLDDALTTVALFAQMSGSDILDSARVLKCRHLLAEFHYYVSHKHLLTKGFISKRGFHFEAQIEGLPVVWLIPHQFTLSKDPDVDYTVLLNFLELYENLLSFVNLRLFKLIGLKYPPEYDQKKWDSGFYIDAIIDNNEQPVVESVAEAPADAKVDMDKVAGIFAKAAAETVENDEEKADSGVFGNYVFTIGRETPRDALALIIRSLGGRIIWDESSKDTSITHTITDRKVINERVLSRKYIQPQWVFDCLNKHSSLDCAPYQPGQVLPPHLSPWDAPVQPEAPEEIDDREVLADDDDDENAEISSEIRQRAMEIEHAEGIAQELGVAKEQTETLEDLKQKKKQMKEKKKEERERLLAGTLPARKAKIYHELKEKEDAKLKKKKGAAKEDADTVRVNEEAMEEEEK
The following text describes a protein:
Function:
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
Sequence:
MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFTGSFKFRGASNKINHLTDEQKEKGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQQATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTIADGCDVKVPGEQTYEVVKHLVDEFILVTEEEIEHAMKDLMQRAKIITEGAGALPTAAILSGKINNKWLEDKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG
The following text describes a protein:
Function:
May act by regulating membrane trafficking and cellular morphogenesis.
Subcellular Localization:
Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome.
Sequence:
MENELLNHPHVNNMVNGHQDATCDSLSMKNDAEMLEQIKQLLMENNNLKETMKQMNQEMKERLEVLLKRHNQHLLDLKSENEVLRKELQCLKERNATYNQGMPACTTSEEASENKQLKNQLMRIQAEKADLLGLISELQLKLGSFSEDSFVEIRISEKESGEKVNEEKANKTPSDHNMSYRTNSVKEEGNGTEPEGAAISRLLRSLREETQKVERLEKELFSANKRLDELEKQTSELCDKDVQTDQKQSQSEVIISSEVNILKEKVKSLNKELQETNDKLKEAKQLKNNLQEKCILLDKRLQENQIDLEEKQSLRYCIKKLELQVESQESEIKLERNKTEAEKNQLAILQVSYDKLNSEHQQLRRSESEKVSKTMFNELLEKLDACEKALAKKQLEIDEMREIDTKHKEDKETIELLRAQIEVYCADFHAEKSARENINQEKEQLADRYAYMMQQNEEMMARHSIEQLQRRHSSTRSVDASESPYIVPRGADNMEQPSITVHTCPKCNLTVPDMDTLQIHVMDCIT
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.
Sequence:
MGDRHDYVALEWVKGEIAETLKQARQALEAFVENPQDPTRMRFCLTYVHQVQGTLQMVEFYGAALLAEEMEQLVQALLDGRVPNQGEALEVLMQAILQLPVYLDRIQTARRDLPMVVLPLLNDLRAARGEKLLSETSLFAPDLSQRQPQLDGEAIAQLRTDELGGLLRKLRQTQQMALVGLLRNQDVATSLGYLARVYARLEGLCREAPLGPLWSIASGLVEGLANGSVVNSASVRTLLRQLDRELKRLVEQGADGLNQAAPDELVKNLLFYVAKAPSQSPRIRALKEQYRLDEALPDHETVDAERARLAGPDRDAMRSVVGALCEELVRIKDSLDLFVRSDRGHPSELDALLAPLKQIADTLAVLGFGQPRKVILDQLDVIHALAQGRREPSDAILMDVAGALLYVEATLAGMAGPGDERNSEESRLPTTDVAQIHQLVIKEARNGLEQAKDAIIEFIASQWNHEHLARVPELLTQVRGGLAMIPLERAATLLETCNRYIQEQLLARKAVPDWQSLDTLADAITSVEYYLERLSEDHASQSDLILDVAEDSLANLGYTLKPNSSAPAEPGLSGPAAIESPAAEPERPEAVVEVAETAEQPPADTAPAEAAREDAPQLASDDNWTLGEVAPDAGEPSLDLALDLPLDDSAEVPPALPEVVEESGQPQSTSAPARSLDDFSLDEIDLSGLDLPADAAPASGPAALADWSLPEQWGLGDDLAQPAQAGETLDLSLEEPALSFDAPLESLEPLPALEPFDGSAEQELVLDALDPLPLDVALPEAEGEVSAWEGSSLEELDLSDLDLPEVQLPEAEAEAPPAAEALASEAPALSLAEVMAAPVQPINPPAQNVPVSLLPPPADEEPVDEELREVFIEEAGEVLETIGRYLPAWKADHDDREALTEVRRAFHTLKGSGRMVRALVIGELAWSIENLFNRVLDRSIAASEPVQRVVDQVVALLPELVEEFAANAQRQRDDVDLLAATAHALAKGEPLPEPPAPDDGGVPPEAGAEQPSSLDNGVQAPPLADAPQAAAEAQSDVELLDPQLLEIFTNEAETHLEALVGFLADCARELPQPVTDALQRALHTLKGSAHMAGILPIAEIATPLEKLVKEYKSNLLAFDLREAELLHDAEQLFRIGLEQVGAQRPLNPIPGSDALLERIEALHQERIASLEAERYSDAGERRDPLLIEAFLVEGMDILLDAEDLLERWHEHPQERQELSALREELSTLDRGARHAELPQVEELCQALLALYDAVEEGRLAVSPAFFEEARQAHEALIGMMDQVAAGLQVTPRPERVAALQELLEAPAAEAVPFIDPESLGADDFPPEDEEPALPEAVYEEAGAPAEETVPAAPAPAPGRELDEEMVSIFLEEAVDILESAGQALAQWQAEPGALSSLSALQRDLHTLKGGARMAEIAEIGDLAHELEALYEGLVDRRYQHSPQLAGLLQACHDRLAEQLDQLSAGQPLADPHDLIQSIRRFRQGPVAEAATPGEAESPVEELVAPAVEEPAAPAAEAFEERDPELVEIFLEEGFDILDSAAAALQRWMDDVDNTIELEALQRDLHTLKGGARMAEIGEIGDLAHELEFLYEGLCGGRLRASPALFGLLQRCHDELAEMLEAVRGHRTLPDGQALIAEIRRLRSDPDEQLSVPTSVSLKPLAAKGAAADESEILDIFLEEADDLLENLELALGRWDGGNGDAQPLDDLLRILHTLKGGARLAGQTELGNLAHDLEQHLTDAQQQGAPWPDSLLLDAQSGLEGLQRQVDLLRERLAEDDEAGERPEPAQALVQADDTDRAVASALAELTRLAPAAGAIMAAEAAPPAAPATTLPFVRKAQEAAQEAASRRAPQELVKVPAELLENLVNLAGETSIFRGRVEQQVSDVGFTLGEMESTIERVRDQLRRLDTETQAQILSRHQADAERAGYEEFDPLEMDRYSQLQQLSRALFESASDLLDLKETLAAKNRDAETLLLQQARVNTELQEGLMRTRMVPFDRLVPRLRRIVRQVAGELGKQVEFVVGNADGEMDRTVLERIVAPLEHMLRNAVDHGIESGETRRAAGKPEHGTIRLNIGREGGDILLTLSDDGAGIRLDAVRRKAIERGLMSADSDLSDHEVLQFVLESGFSTAEKVTQISGRGVGLDVANSEVKQLGGSVSIQTEPGQGTRFNVRLPFTVSVNRALMVLSGEDLYAVPLNTIEGIVRVSPYELEALYDQRGEAGLDTPSFEYAGQSYELKYLGELLNNGQEPKLVGQSLPLPVILVRSSEHAVAVQVDSLAGSREIVVKSLGPQFAGVAGISGATLLGDGRVVVILDLLATIRSRHALLGQESRRERLALRQEMAASESEQQRPPLVMVVDDSVTVRKVTTRLLERNGMNVLTAKDGVDAIAQLQEHRPDILLLDIEMPRMDGFEVATLVRHDERLGNLPIIMITSRTGEKHRERALGIGVNQYLGKPYQETELLEAIQSLVGQHE
The following text describes a protein:
Function:
Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated proteins, leaving the prenylated cysteine as the new C-terminus.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRVYLISFFFTAIYVVSLYTFPVARPRPSLNRNDPKVITARCISVLLASSVCCILTRLIIGPSLNVFTFPTDQVLKSLLHAATIFIGPLYEVWIVDKEYRLFFIHLKDCLSNAIAWRNIIIGPLSEELTFRCCIVPICEAAGWSRLKIIFVAPLLFGMAHIHHTYEFLLAYPNAYIAAALQTVVQFSYTTVFGWYTTHLFLSTHSLFPSFLVHAFCNSMGLPTLYGKIGNRNQTRIYYTLLLLGVLIFYMTWGITDFNNHQDFEPRLVPLN
The following text describes a protein:
Function:
May be involved in pectin and/or xylans biosynthesis in cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKFYISATGIKKVTISNPGVGIGKGSGGCAAAAAALAARRFSSRTLLLLLLLLAIVLPFIFVRFAFLVLESASVCDSPLDCMGLRLFRGGDTSLKIGEELTRALVEETTDHQDVNGRGTKGSLESFDDLVKEMTLKRRDIRAFASVTKKMLLQMERKVQSAKHHELVYWHLASHGIPKSLHCLSLRLTEEYSVNAMARMRLPPPESVSRLTDPSFHHIVLLTDNVLAASVVISSTVQNAVNPEKFVFHIVTDKKTYTPMHAWFAINSASSPVVEVKGLHQYDWPQEVNFKVREMLDIHRLIWRRHYQNLKDSDFSFVEGTHEQSLQALNPSCLALLNHLRIYIPKLFPDLNKIVLLDDDVVVQSDLSSLWETDLNGKVVGAVVDSWCGDNCCPGRKYKDYFNFSHPLISSNLVQEDCAWLSGMNVFDLKAWRQTNITEAYSTWLRLSVRSGLQLWQPGALPPTLLAFKGLTQSLEPSWHVAGLGSRSVKSPQEILKSASVLHFSGPAKPWLEISNPEVRSLWYRYVNSSDIFVRKCKIMN
The following text describes a protein:
Function:
Involved in response to osmotic stress. High-affinity glycine betaine-specific uptake system, which couples the uptake of glycine betaine to the symport of two Na(+) ions. Transport is driven both by the Na(+) gradient and by the electrical potential. In addition, functions both as an osmosensor and as an osmoregulator that transduces signal to the catalytic part of the carrier protein, which adapts its activity to the extent of osmotic stress.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Contains a negatively charged N-terminus and a positively charged C-terminus, which are both involved in sensing and/or transducing osmotic changes to the domain responsible for the translocation of the substrate glycine betaine. The C-terminal domain is directly involved in K(+) sensing or K(+)-dependent activation of BetP.
Sequence:
MTTSDPNPKPIVEDAQPEQITATEELAGLLENPTNLEGKLADAEEEIILEGEDTQASLNWSVIVPALVIVLATVVWGIGFKDSFTNFASSALSAVVDNLGWAFILFGTVFVFFIVVIAASKFGTIRLGRIDEAPEFRTVSWISMMFAAGMGIGLMFYGTTEPLTFYRNGVPGHDEHNVGVAMSTTMFHWTLHPWAIYAIVGLAIAYSTFRVGRKQLLSSAFVPLIGEKGAEGWLGKLIDILAIIATVFGTACSLGLGALQIGAGLSAANIIEDPSDWTIVGIVSVLTLAFIFSAISGVGKGIQYLSNANMVLAALLAIFVFVVGPTVSILNLLPGSIGNYLSNFFQMAGRTAMSADGTAGEWLGSWTIFYWAWWISWSPFVGMFLARISRGRSIREFILGVLLVPAGVSTVWFSIFGGTAIVFEQNGESIWGDGAAEEQLFGLLHALPGGQIMGIIAMILLGTFFITSADSASTVMGTMSQHGQLEANKWVTAAWGVATAAIGLTLLLSGGDNALSNLQNVTIVAATPFLFVVIGLMFALVKDLSNDVIYLEYREQQRFNARLARERRVHNEHRKRELAAKRRRERKASGAGKRR
The following text describes a protein:
Function:
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
Subcellular Localization:
Cytoplasm. Endosome. Nucleus.
Sequence:
MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPEWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR
The following text describes a protein:
Function:
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MRRSWAARLWSRVGGGRSGGGGGGEGRMRLWGAALQAAGRAGRREGFPLQGHDVARWFPGHMAKGLRKMQSLLKQVDGVIEVHDARIPLSGRNPLFQETLGIRPHLLVLNKMDLADLKEQKEIVHHLEKEGLKNVIFTNCTKDENINQVVPLVTKMIESSYRYHRGENPESCIMVIGVPNVGKSSLINSLRRHHLRKGKASRVGGHPGITRAVMSKIQVCERPLMFLLDTPGVLAPRIESVEIGLKLALCGTILDHLVGEDIMADYLLYTLNKHQRFKYVDHYGLGEACDDIRSVLKRIAVRLRKTQRVKVLTGTGDVNVIQPDYSAAAYDFLRAFRSGGLGRVTLDAPAPREPPPPAVATVGGHAPAPGSAG
The following text describes a protein:
Function:
Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity. Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-108 to the substrate (generating a bisphosphorylated substrate intermediate and a dephosphorylated enzyme), a 180 degree rotation of the intermediate (probably aided by movement of domain 4), and subsequent transfer of phosphate back to the enzyme.
Miscellaneous:
MISCELLANEOUS: Most crystals have Zn(2+) rather than Mg(2+) and are catalytically inactive.
Domain:
Consists of 4 domains; domains 1-3 have a similar toplological core while domain 4 folds over and closes the active site from a hinge region. Mutants in the hinge region (residues 262 and 368-369) generally increase KM for glucose 1-phosphate 2-fold while reducing kcat about 10-fold.
Sequence:
MSTAKAPTLPASIFRAYDIRGVVGDTLTAETAYWIGRAIGSESLARGEPCVAVGRDGRLSGPELVKQLIQGLVDCGCQVSDVGMVPTPVLYYAANVLEGKSGVMLTGSHNPPDYNGFKIVVAGETLANEQIQALRERIEKNDLASGVGSVEQVDILPRYFKQIRDDIAMAKPMKVVVDCGNGVAGVIAPQLIEALGCSVIPLYCEVDGNFPNHHPDPGKPENLKDLIAKVKAENADLGLAFDGDGDRVGVVTNTGTIIYPDRLLMLFAKDVVSRNPGADIIFDVKCTRRLIALISGYGGRPVMWKTGHSLIKKKMKETGALLAGEMSGHVFFKERWFGFDDGIYSAARLLEILSQDQRDSEHVFSAFPSDISTPEINITVTEDSKFAIIEALQRDAQWGEGNITTLDGVRVDYPKGWGLVRASNTTPVLVLRFEADTEEELERIKTVFRNQLKAVDSSLPVPF
The following text describes a protein:
Function:
May play a role in regulating vesicuar trafficking in cells.
Subcellular Localization:
Endosome.
Sequence:
MAPFGRNLLKTRHKNRSPTKDVDSEEKEIVVWVCQEEKTVCGLTRRTTSADVIQALLEEHETTFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDSVSQDRDSMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPNFSEVEQKLGLEYDENQILEDLSESDGILQLEERLTYYRKLIDKLSAEIEKEVRSVGTEINEDAEGAAASELESSNLESVKCDLEKSMKAGLTIHSHLSGIQKEIKYSDSLLQMKAKEYELLAKEFTSLHISSKDECQQKDNRGKESEVTTISGEVPPFTQKVFNTHTNDTDSDTGISSNHSQDSEATGGDAVLWSP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDPNQMDGIPSAGLNIRDEQMSGLETDSQDVQPSDASFDLGENADELNKSLSATVKPFQCSQCGKGFSRIQHLSEHVRIHTGERPFQCLECGKTFARERDLKTHQLVHTDAKAFHCVICVKNFALLSSLKRHLRAFHQGEDVSTEGKCLICVECGKNFDCDLEEHELTHTGEISHRCPDCVNSFSDPSNLTSHDQTFSESDHVHHLEDNDNERPCGSLASEDVDRHLQTDPLNDCGEAQSVEFADNIESDGFNESSAQIQLEEAERAASPSSEHSLDSAQKDTGPGYAPPDEEFTADQQSSDEEKPYQCNHCEKRFNKQAKLRIHLRVHTGEKPYQCSQCGKHFSQDVNLKKHYRTHHTEEKPYQCMICDRKFSVSFSLIKHQRVAHPECLSVAERKRFTCPFCGKIFGRHQDMEQHKRTHTDERPFRCNVCNKSFRQRSVLIVHRKIHTGEKPFECFVCCRRFYGSGDLKTHMGTHTGIRPHSCPLCSKSFPRPSSLQAHMLSHVNKQQDRNDGGFPQEEELEDACGASGSSAMLSEDKTSNQSETGMDLSLSANQDHDANPSSSSELPDHQKPYFCIICGKTFALATSLRKHQLIFHPDQHVDVEGKCFACSYCGRKFGRRQGLLQHERIHTGERPFNCPTCNKSFRQRSALVVHIRSHTGERAFVCFVCNKSFYTPGDLKKHLEIHTGVRPHNCPICSKGFGRPSFLRTHMRTHEKTSAKKQSGSENAAGKPKASSQEKPFECSHCGKKFSQQCMFKIHQRIHTTEKRYKCTECGLSFRWRRNLISHQSTHPGQNPLQCSMCDQTFISEAAVKSHQDTFHSGVSHTCSLCLKTFTKSAGLRKHVRYVHEGERPHKCTECNRGFVKVSDLARHQRRHHYDRGNQLFQCSECERSFSHPSSLVLHRRTHTEEKHQCPQCDKIFNQAGHLKVHMRTHTKEIKPKFECPDCGKSFGQTKDLMVHQRVHTGEKPYQCPQCKKSYRQFAHLSVHLRSHTGEKPYQCPICLKFFAHSSSMKKHLRVMHPDAKDAPVGAGPSNTSVEVKQEPVSSDEDEFQVKSEENDFAIMDEVKTVTVSSCPSSPMTLKEEK
The following text describes a protein:
Function:
Required for cellular morphogenesis and polarization of the cortical cytoskeleton. Required for establishment of new polarized growth zones where it acts in actin organization. Involved plasma membrane internalization and is essential for fluid-phase endocytosis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Localizes at cell ends during interphase and to the medial ring at cell division.
Sequence:
MSSFRLQSDHMQSDASLMTSVRKATSIDETAPKRKHVRSCIIFTWDHHTARPFWTAIKVQPLLANEVQTFKALITIHRVLQEGHKSALVDSQSEKGWLKTCERQYDGESSPKGYSDLIRDYVDYLLDKLSFHAQHPEFNGTFEYKEYISLRQVDDPNEGYETVYDMMNLQDHIDEFQKQLFSNFKRSNKNECRIAALVPLVQESYGIYRFLTSMLRALYSTVDAPETLEPLKHRYKSQHHRLRQFYADCSNLRYLTSLISVPRLPHDPPDLEGDDNIPDLPKRPASIAPQPTGASTIAPQPTGTSPSPPVEMNFPDTSDITPAYSEPEPIQDFWSDPTLDQQLAAQQAAQQAAQQQAELAAQQAAAQQAQLAAQQAAEMERQRMAAQQHQQALEAIQMAQAEQQRIAQEQLAQQQFQMQTQGQLAELEQQLLATRGQLEQSNVLLNQYDARVRTLENELSQAGVNLQEQIHQNDDLIESLKNQILTWKNKYEALAKLYTQLRQEHLDLLSKYKQIQLKASSAQEAIDKKEKMEREMKNKNLELADMILERDRARHELETMHRSQRDKQESTERELRLLQEKAASLERNKSSEVSNLLSRYNTEVAHLEDALHSKDRELANLGVELKSTENRYRQLLQEKEEELEIQKAAVDESLLQLSKLQLDRNDIDQAMDTQIDELLKSQLEKLDDIVDSVLATGIQRLDTSLYELDSPMHAGNQYATPEFILSTIENASNNATDFSTAFNNYFADGPNADHSEVINGVNLFSTAIYEVANNAKGLSRTTGDDQGSDRFVGLSRDLVNMAKRFLSSLFSVNTRKMDVNVKTDLVIGENIELQRYLQQLTQYSEKFLNKESENTVGLLNAPGENIEELVDNQLAETAQAIQQAILRLQNIAAKPKDDSLSPSELQVHDSLLSASIAITEAIARLIKAATASQAEIVAQGRGSSSRGAFYKKHNRWTEGLISAAKAVARATTTLIETADGVVNGTSSFEHLIVACNGVSAATAQLVAASRVKANFASKVQDHLEDAAKAVTEACKALVRQVESVALKAKEVQHEDFSSLGVHEYRRKEIEQQVQILKLENDLVAARRRLFDMRKTSYHVAEE
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSEGKTLPTQGNTRTMNIDSILFTNITHSDYMFKTLGSIHSISDLIDIIINDVHYISPYIQKSSSSPSTAFCVLLRLFQLNPTPDDIRMMSTHSNKYVRCIAALIIRYSIQFNLLLSYLKPFVDDRAVVNISLHGEKTKQIKCLVKDLILEPKFEGCILPRIPQVYYKPLLEFFKGTSQPNSHELDEDSLTSFSDLKKFVQYSDHHQREHSRPPTSNLRYSRSCRQRSSYRERSRSDSRERRKNYYEERRYDSRKN
The following text describes a protein:
Function:
Constitutive protein of the cell wall. Binds fatty acids and may thus serve as a fatty acid transporter between P.marneffei and host cells during infection. Abundant antigen target of host humoral immune response.
Subcellular Localization:
Secreted, cell wall. Note=Associated with the entire thickness of the cell walls of yeast and conidia found in mold form. Localizes on the outer layers of the hyphal cell walls.
Sequence:
MKFLSSLVVLGLSAQALASPYVDHQATKDQRDVNVFKQVLQDINLDVQKFDQDITQYQGGDPTVLLADSDAIIKTTEEGIQRIGPQPPLSVTEALALVGPVQGVNKLIMKAVDHLIEKKGPLVGGGYGPQVKDSLERQAHAASKLSELVSSKVPSPLAPISKQLSDQVAQALQKGIQAFSISARQATKVKREATKVQRDISAFKKVIQNISLAVNKFNVDIERYVGGDASHLLADGNVLIKATLDGVQSLQNEPPLSSMEALALVGPVQDLSNQILLAIQNLIDKKEPLVQAGFGGKVENNLRQQEEAAQKLSELVSTKVPHELADISRQLSDGIAAGIKKGIDAFAGTGPAPTTSSTPEASTAPAPSTPPQTPEDTLVPATSTPAPGPAPTAPDSSMVWPTSTTASPDVQPTITSSGTSVPAAPTGGNSSPAVPAFTGAASANQVSGAVGLAAGLLAVLAF
The following text describes a protein:
Function:
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.
Sequence:
MKHFLRMLIQVCLYFYCKFLWRCMKFVMRKLTGRCELQRICYGTKPGASRTMKIETSLRDSKSKLLQTSVSVHPDAIEKTIDDIMELKKINPDINPQLGISLQACLLQIVGYRNLIADVEKLRREPYDSDNPQHEEMLLKLWELLKPNTPLESRVSKQWCEIGFQGDDPKTDFRGMGLLGLYNLQYFAERDATVAQQVLSDSVHPKCSKFSKIEWEKKKMDKAIGYSFAIVGINITDLAYNLLVSGALKTHFYNIAPEAPTLSHFQQTFCYLMHEFHKFWIEEDPMDIMEFNRVREKFRKRIIKQLQNPDMALCPHFAASEGLINM
The following text describes a protein:
Function:
Late protein which functions to suppress polarity of amber mutations in the late genes of the P2 helper phage.
Sequence:
MESTALQQAFDTCQNNKAAWLQRKNELAAAEQEYLRLLSGEGRNVSRLDELRNIIEVRKWQVNQAAGRYIRSHEAVQHISIRDRLNDFMQQHGTALAAALAPELMGYSELTAIARNCAIQRATDALREALLSWLAKGEKINYSAQDSDILTTIGFRPDVASVDDSREKFTPAQNMIFSRKSAQLASRQSV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLHAVDSHASTIIMEDKKTSLEVIKSEIKEEPQSSEEPYKTYIVKEEDLEDDWTENDAKEVSEEQQSSERTEKSQVKEDHLKEGQQGEEVQRRFHTDSVLEADSEDGWTEDDDAKETEAQQSKEADHQTLTYFIKEEPADSDSADDDDERTALQATSQSCSKQGGDSSVLTCYQSMRNTEEKSNDRSFDDARGPSLPEDFPLEAGRGTQSDSSERESCPSEYDSCLIPSQVAYFHEKRAADRETSDATTSYHKPGGMDKDRNEDITMECDEMINQSSQLHATGSDQKDPSCSLTREKPFLCCVCSKGFALRTSLSRHMRTHGGKKPHECMLCSKRFMYMNILKEHLRIHTGEKTYRCTVCDKGFCASGNLAQHMTVHTGKKRYECGDSSLQSSYQSMRNSQEMSDDKSCDGARHLPEDFPLQDYLGTQSDSSERESCTSGDSSLQSSYQSMRNSQEMSGDRSCNGARHLPEDFPLQDYLGTQSDSSERESCTSGNTRMQSSYQSMRKTQEMSGDRSRDGE
The following text describes a protein:
Function:
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL