lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSEQRVSQPKTPVSNEEKWDHSLENFFRKTTLGLAYSILPAFLLARSAAARGAILMFATGIGSGIAYGEARYLFDHDVVFDRRHLVHIELLKPKESKIN
The following text describes a protein:
Function:
Plays an important role in mitochondrial mRNA editing by promoting the assembly of the mRNA editosome. Facilitates the recruitment of mRNA to the REH2C complex and promotes the interaction between various editing complexes including REH2C, GRBC, REMC and RECC complexes.
Subcellular Localization:
Mitochondrion.
Sequence:
MRRWLVASMAPQLHQLLQPVRRCHHPLRIPSVQLAAPRSHTHEDIAYASCPACSRVVHMCDMLTHLITAHRELDQTHCRKMCTERLALYERVIGVPLKKSELTSSGRRVLDFLPTVLPTGYMCNWCDRRSDVYATRDKFLKHVADVHTDIDLEEVEPHVPLPPRGVVVEKSNGDGGPQPTRRLNGVVAVAEKSEPINAVPRILGISLPRGVDRPLKATAQFSDTEFPCELCNRTFNSEIDLLQHLETRHPDGTAEGPAGVDSAAIADVAQFSAKEATTGGDQRVHVICDLCVSSSKVYKMPSALFSHIRFKHPNEDAAFHVERLIREQKTVSSFVCTVCQKAFASAAALDGHFNSKHAEQGEAQNVVGRVTANNCWWCHDCEKGFSSAKGLHGHMQNKHGLSSQTHPCPACKRVFADIYSLEEHLSLQHKTIRLSDIGLLTHVKCSTCERFFLSHEDLHRHAVKHHKKDPRAPAQPFEAPTSASHVAASTSAAVPSEVEATASPQGPRKVKKRKKTTEVSEVTS
The following text describes a protein:
Function:
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). Essential for early embryonic development (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASILLRSCRGRGPARLASPRAASPRGSLRDRACLSCTRTVGLTSHESVLSRCCTPANPVYLYFKSEPLSCWTQRPECQGTVARAAWTPASARLVVTGPQYLPVRGWHSSSPLGEDSMIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVKKSLGQKILDELKHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLYHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKAAEVEGEQVDNKAKLEATLQEEAAIQQEHLEELKRAAETAKDIQPEVAEATVPGRPGAELQPKMVDVIPPSEILKDTAPVLEGLKGEEITKEEIDILSDACSKLKEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGDEKYIEESTASKRLSKRVQQMIGQIDGLITQLETTQQNGKLDPAAASSPTGESVISVDELISAMKQIKHIPEHKLISLTSALDENKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEEKVEEKEKAKEKAEKEAAEVKN
The following text describes a protein:
Function:
Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (By similarity). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors. 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (By similarity). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (By similarity). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (By similarity). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (By similarity). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (By similarity). Plays a role in the inactivation of RHOA in response to NGFR signaling.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum. Note=Recruited to the cell membrane by NOD2 following stimulation by bacterial peptidoglycans.
Domain:
Contains an N-terminal kinase domain and a C-terminal caspase activation and recruitment domain (CARD) that mediates the recruitment of CARD-containing proteins.
Sequence:
MNGDAICSALPPIPYHKLADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFEDITFLEAVIQLKKAKIQSSSSTIHLCDKKMDLSLNIPANHPPQEESCGSSLLSRNTGSPGPSRSLSAPQDKGFLSGAPQDCSSLKAHHCPGNHSWDGIVSVPPGAAFCDRRASSCSLAVISPFLVEKGSERPPIGIAQQWIQSKREAIVSQMTEACLNQSLDALLSRDLIMKEDYELISTKPTRTSKVRQLLDTSDIQGEEFAKVVVQKLKDNKQLGLQPYPEVPVLSKAPPSNFPQNKSL
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVGWGVAVLCLWVSCGAAAGQLEYSVPEETERGVAVGNLSADLRLPAAAMSSRNFRFLSSHRELYFGVDLPSGNLVVREPADREQLCRAKAACVLTYDLVLEDPLELHKIRIHVLDTNDNSPLFPAGDVQLHIPEFLTPGARFALPNAQDDDEGSNGILSYSLSPSQHFRLDMGSRVDGSEYPELVLEKALDREQRATHLLVLTARDGGLPARSGDAQVTIIVVDTNDNAPVFERSVYRTKVPETAPNGTVLFRVQALDPDEGSNGEVQYSLSNSTQAELRHRFHVHPKSGEVQVAASLGPPETLLEAYIEARDEGVFGLASTAKLLVEVTDVNDHAPELDFLTLSNPVPEDAAPGTVIALFSVKDEDLDSNGRVICGMSSAGPFQLTASFDNYYSLLIDGPLDREQISEYQVLITASDSGSPPLSTRRTITVSVADVNDNTPSFPQPQQELFIAENNGPGASLGRVFAQDPDLGKNGLVSYELLDVISEGPSASSLVAVESSSGAITAKTSFDFEQLRGFHFQVEGRDGGIPPRSATVTINLFVVDRNDNYPVILFPLPRNCSVPVEIVPRSARTGHLVTKVVAEDADSGSNAWLSYHISRASDSSLFRISANIGELRTARLVLPTDAVKQRVVVVVRDHGDPPLSSSVTLGVLLSNSVPQLLPDFEDVWEPGGQLSAQNLYLVIALACISFLFLGCLLFFVCTKLHQSPGCCAQSCCRSTEDLRYGRKMVSNPCMTSATIDVTTVERLSQTYLYRASLGLGSDNNSLLLRGEYNAADLRNLATGVGLNLPISCIQIRNRKGDHANVNAMPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
The following text describes a protein:
Function:
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
Subcellular Localization:
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity).
Domain:
The C-terminal domain (CRD) is essential for the LDLR-binding and degrading activities; The catalytic domain is responsible for mediating its self-association.
Sequence:
MGTVSSRRLWWPLPLLLLLLLGPTGTRAQEEDDDDYEELVLALRSEEDGLVDALQHGATATFHRCAKDSWRLPGTYVVVLKEETHRSQPERTARRLQAQAARRGYLIKLLHVFHDLLPGFLVKMSRDLLELALRLPHVDYIEEDSSVFAQSIPWNLERITPARYRADEYQPPNGGSLVEVYLLDTSIQSGHREIEGRVMVTDFGSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASLRSLRVLNCQGKGTVSSTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSRSGTSQAAAHVAGIAAMMLSAKPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAMARCAPDEELLSCSSFSRSGRRRGERIEAQGGRRVCLAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAGAGMGTRAHCHQQGHILTGCSSHWEVEDLGTHKPPVLRPGGQHDQCMGHRGASTHASCCHAPGLECKVKEHGLPAPQEQVTVTCEEGWTLTGCSALPGTSHILGAYAVDDTCVVRSRDVSTTSSTSEETVATVAICCRSQHLAQASQELQ
The following text describes a protein:
Function:
Required for arginine biosynthesis. Transports ornithine synthesized from glutamate in the mitochondrial matrix to the cytosol, where it is converted to arginine.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGLPVHNQPHKAHSGSPASTFSAALVSSAISNVIGYPLDSIKVRQQTYNFPTIRSCFQNAVKNEGLKGLYRGLTLPLISATLSRSVSFTVYDSLKLTFAHVDPTLRYFISGLGTGTFISLFACPFEYSKLYSQIDMLLRKTNMGRRQETNSKLSVRPPLSSFQSASDIVRRYGFTALWNGYRYHLTRDALGSACYFTIYETFKKNLIANDVKPHFAYAFSGAFCGALSWILVFPVDTAKSIVQRNTLLSIKTPLSSIPWLSFTIYRGIGISLMRSALINSCNFTLFELFRETKVLSK
The following text describes a protein:
Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Subcellular Localization:
Basolateral cell membrane. Cell projection, cilium. Cytoplasm. Nucleus. Secreted, extracellular space, extracellular matrix, basement membrane.
Domain:
The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
Sequence:
MESVFCGKYKETTITMSFMQEFLAQASFMESGGHPPCTAEESGPSLKANPGFNAAADAANLDKAIKAKGVDEGTIIDILTKRTNSERQQIRAAYQQLTGKTLDDALKKCLKSHLEEVVLGLLKTPAQYDAHELRGAIKGLGTDEDRLIEILVSRTNSEIKEINKVYKEEFKKDLAKDIAGDTSGDFQKTLLALAKGERNEDARINEDQADNDARALYEAGEKRKGTDVPTFINILTTRSYPQIQKVLQRYARYSKNDLNKAIDLEMKGDLEKSLMSIVKCASSKPAYFAERFYLAMKGSGTRHNALIRLLVSRSETDLNEIKTCYKRLYGKSLRQAIMEEKLKGDYETIMLAMCGSDN
The following text describes a protein:
Function:
Plays a role in synthesis, processing and/or stability of 23S rRNA.
Sequence:
MSANVPEMLDAWRMVAARRRFDGRIPLSAMTRLQGSLVDTEGECVYSLQFDQDDLLKVAYVELSIDVALPLECQRSLQRFLYPVQIRQRLGLIRDEADEAALPPDYEALLVPDDGMLRAVDLVEDELVLAVPVVPMAPGSEAVEAEWVPTQEEQDKASPFAALAALKKQ
The following text describes a protein:
Function:
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MISNQDNIIQVSAPGKIILFGEHAVVLEKTAIASALSLRTTVTFTPNTNNTLLLDFPDLAGFGVREWSLDEFKKLDHFPNDIDILKPIECSELFQQELNKIIDIKGIHTFLFLFCALTKCTKAYNIKITSDLPIGAGLGSSASFCVSICAGLLKAFDTYICGGCKQCIGGQGQQQQICNEQLNLINLWSLQGEKIMHGTPSGIDNAVATFGKALTFTRKNGYKILENGIPPLRILITNTRVSRSTKTLVEGVIQRSKLYPTLIDPVSNLIDTISSQCIESFNQYHTDKDYEKLQQTMDLMFDMNQHLLSGCYGVGHSSIDTIVSITKSLGFHTKLTGAGGGGCVITLLKQDTTIDQLSNLKLTLSSNGFESWEATIGDPGVSINILPIQK
The following text describes a protein:
Function:
Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MACERLGGQSGAADVDAAAPAMAAVNLTLGFAGKTVLDQVSMGFPARAVTSLMGPTGSGKTTFLRTLNRMNDKVSGYRYSGDVLLGGRSIFNYRDVLEFRRRVGMLFQRPNPFPMSIMDNVLAGVRAHKLVPRKEFRGVAQARLTEVGLWDAVKDRLSDSPFRLSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRLTVIIVTHNLAQAARISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVAGLSGDVKDAKRGN
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MPAAILPVDVEGIPQDNSAAAACPSIRDADQENEPEAKEQKKSWKIPKISKKGRRAMAAFVVFVVAAVYVGCFVGFRMSRSNNNSIFVNSNDICNNTLYPSACNDTLFGSDTTNSRVVASKSVKASLKSTNETYLNLTRCRDSWPSSRIGIQYSTLEMCVEMYQETLDATRRCLHAVDSSEVTQVGDLEQALSAALTYHFTCVDGLRERKVSCEVNIDRNTELLSNALSLLQRLNSSNAKGTPLPRRRLLAAPEGLTRASKLSPDERTRIYEMDDDNHDVFPTWLSKKDRQLLTSTSSVTPDSVVALDGSGNHKSIQTAIDEAPTNSSKRYVIRIKAGIYVEQVKVPRDKTNVTLLGDGAGMTIITGNRSVAVDQTSTIFTATVTVLGNGFVAKALTIRNTAEPSGEQAVALRVTSHQSAFAYVFIEGYQNALYAHVNWQFYTSCTIVGTVDLVFGSAAAVFQQCTLQAKPPNPDDMITFTASDIASPLVQQFAGLVFEACAIDAASDSVEAGTAYLGRPRHQYARTMYIKSSLGKVVTAEGWTLWNAQISSMLHVDYGEYANFGAGSDAKLRVPWSRILYPEQAKKFGVDEFLQGRRWLPNLDIAYTGSI
The following text describes a protein:
Function:
Regulator of sister chromatid cohesion in meiosis which negatively regulates cohesin association with chromatin, acting as an antagonist of CTF7. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity). Essential for the prophase removal of cohesin during meiosis thus determining the timely release of meiotic cohesion. Important for proper spindle attachment and assembly during meiosis. Helps to prevent abnormal centromere association during prophase I in meiocytes. Required for early embryonic patterning. Also involved in chromosome segregation during mitosis.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MIIVKLTANRICCSLLQLRRSYEHFYIFVFLPEIPLFRFSHLKLFPKNLQIQRLVSAMMERTYGRRKPGIPRTLSDSLNDSVSQTEYLSSSSSPDIEPIDYSLLPFSSQESSSLWHSSSRSNFREDYPQNGGVVRRAKRVRNGAEAAAFTSTLLEAQEFGELMEHEDEVNFALDGLRKGHQLRIRRASLSSLLSICASQHQRRSLRAQGISQSIIDAILVLSLDDIPSNLAAATLFFALTADGQDEHFMESPKCIKFLIKLLKPVIVTSTEGKPRNIGFKLLSLLKDVDAARDPVKMDDPSSSDILSRVQELLVNCKEMRLNDSYITETTRPELSTKWVALLAMERACVSKISFDDTSGSVKKTGGNFKEKLRELGGLDAVLEVVMDCHAVMERWVEYDALSVQEKKDNLHKQSLMLLLKCLKIMENATFLSTDNQNHLLGFKKCLGSHDSRMSFTELTISVIKMLSGLHLRGGFSSPNTNNVNSHYSNGGNHDSVLEANRKVTNEVVTISSDTYSTVGSISTRNGSVSQRSQSIIHLDFSPTSMSGSQSSVSGNEPTTSKTRVGSTISGSFAGRLASLGSDIARTTLRTTQAGEPICKKFGEFAPPEESEDPFAFDLEDYKPSKWAVVSVNQKKSRAQKKKGCYKQSKDESLYQLFSSQEESSNHRLNSQEESSNRDCSTSLQPSHCTNDIDEECLCLLFDCLLTAVKVLMNLTNDNVVGCRQVGGCRGLESMAELIARHFPSFTRSQLFSEMEKTGSSHQKKDKYLTDQELDFLVAILGLLVNLVERDGVNRSRLASASVPITKPEELQESEQEMIPLLCSIFLTNQGSAETKEETTTFTLDDEEAVLEGEKEAEKMIVEAYSALLLAFLSTESRSIRNSIKDYLPKRNLAILVPVLERFVAFHMTLNMIPPETHKAVMGVIESCKSP
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPPSQLKRLKASLREQGIVGPQQSKKQKKQNAQNGANKEKKIKRSVALSGIRDQFNPFEIRQAKAPKFEVTSNKTLSGRISKGIKKPGVARGLAEENRRKTLLVEMQSRNRVGGIIDKRFGENDPSMAPEDKMLERFTQEKQRGHKNSSAFDLEDDEVSGELTHMGQSLSLDGPTIRDDFDDEGLELSDADDHESDEERQARKRRRGSNSEGSDEDEEGNSLPERKKSKQEVMKELIAKSKMHKYERQAAKEDDEDLREELDKEMSGIHELLRGMAAKPPPPPPAPPADIPGMNPERIALMNGGDRAKLEKEYDIRMRQMAQDKRSQPTERSKTEDEKMEQESRRLKELEAKRLRRMEGVTEDSDDEEDNKPRRVGDEEEEEEEEEEDYGLGSGIKTRPSAAELGADDEDDFIIDDDLVASGSDIDESEGESDEEDGESDNEDDEFLEGLLTEEEAKRPEFLTGANAPLPEVEMPTKNGVNGDLAYTFACPQSHEELLEITRGIALLDLPTVVQRIRALHHPKLNSENKGKLGNFSVSLISHISYLANQAQQPPFSVLENIIRHIHSLAKTFSLEIANAFRRHLDEINQSRALSLKAGDLVILTAIGTIFPTSDHFHQVVTPAILTMGRYLGQKIPQTLSDYTMGAYLCSLCLQYQRLSKRYVPEVVGFIENTLCALAPSKLAKIPGCFPYHEPKSSVRIEKVTESDRQIAFYDCVALESSADDEESSKAALLEATIKILNASADLWTDKSAFTEVFEPVLTILKHLGSKSCRSKLSESSQTLIRKSRSKFQTMLQLAHLARRPLELHHHKPLAIKTSIPKFEDSYNPDKHYDPDRERAETAKLKAEHKKERKGAMRELRKDSNFIARESLRQKKEKDAAHEKKMKRLIAEIQGEEGKEAKAYEREKEWRKKGKR
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MALGRQVYNLLFRRTSTFALSVVVGALVFERAFDQGADALFEHLNRGKLWKHIKHQYETPEE
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPEYCFIQGCPNHYRGKKTLGATTNVTDPTKSRLFRVPKDDILKKIWSEKIPRTVITRESLMETESMTRALIPEDVTSRQVVSPQNLGFVAGVILRERLFDDAGHGLLMTLFALWMVVKEKPLAAKKIQSEIWVICFAGRYIMLLMGLFSIYAGFIYNDVFSKGVNIFGSAYKVNLTDHELQHHHSGMLVPNEANNHYRQTPYPFGVDPIWMLAENKIPYLNAYKMKISIIFGVVHMGFGVILGIWNHRGSYPWMCTFDSHHLYWHGTVQVRDDTVALDGCENYMYPGQETLQKVMIITAVLVVPILLFGKPILFKMEMNKAKNHAVNYFLSDYLDVFSKLPIFIQTLHNHNGTAEGEDVEVAGVPQTENHEGGDEPHEFSDVMIHQAIHTIEYVLGSVSHTASYLRLWALSLAHSQLSEVLWLMVLRKGLMFQDWYGGVILYFIFAAWAALTVSILVLMEGLSAFLHTLRLHW
The following text describes a protein:
Function:
This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing.
Sequence:
MKSGIYQIKNTLNNKVYVGSAKDFEKRWKRHFKDLEKGCHSSIKLQRSFNKHGNVFECSILEEIPYEKDLIIERENFWIKELNSKINGYNIADATFGDTCSTHPLKEEIIKKRSETVKAKMLKLGPDGRKALYSKPGSKNGRWNPETHKFCKCGVRIQTSAYTCSKCRNRSGENNSFFNHKHSDITKSKISEKMKGKKPSNIKKISCDGVIFDCAADAARHFKISSGLVTYRVKSDKWNWFYINA
The following text describes a protein:
Function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MTLLNISGLSHHYAHGGFNGKHQHQAVLNNVSLTLKSGETVALLGRSGCGKSTLARLLVGLESPAQGNISWRGEPLAKLNRAQRKAFRRDIQMVFQDSISAVNPRKTVREILREPMRHLLSLKKSEQLARASEMLKAVDLDDSVLDKRPPQLSGGQLQRVCLARALAVEPKLLILDEAVSNLDLVLQAGVIRLLKKLQQQFGTACLFITHDLRLVERFCQRVMVMDNGQIVETQVVGEKLTFSSDAGRVLQNAVLPAFPVRRRTTEKV
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MMLNLVVADGPRQLSAREKAAKLKKSGLSFAQRKALREEEKKNAWKKEQGGITTTIEDRMKRREQDNPPVRPKPYDKPYEKKPYEKKPFEKKPYEKKSYDKPVASKPVEETDEEKYQRLMEGGKRPEKERWVPQRNFRNRRDMEKAGKDQSQDATPKHHDRDVIGTREDGSLIRRIREKTGAKGGIKGTYVSSIFSEKKEDRIAGEDVQMEDEEEEEAENNAESSNAALKDSTTFSGLGCSQRLVDALVGMQLAKPTKIQRATIPRLIQRERDLFVQAQTGSGKTLAFVLPVLERIMSCDDVSRETGLFAVILTPTRELTTQIYSVLETLCRKACPWIVPGIVIGGEKKKSEKARIRKGVNILVATPGRLADHFDNTEALDLSQVRWVVLDEGDRLMELGFEETITKILRTIEWKSVLRGENYLKDIPKNLKPLPSRRVTVLCSATMKGGVTELGKSTLKDADWVSNDSVEDALAETSVETFSAPSQLVQEWVVVPAKLRLVTLLGALRGDILQSSEKTNTKVIVFLSCSDSVDFHFDVLSRDGSQINKMDTAKTAPLLLDDVSTSVYKLHGSLSQQARTATLASFAKNSTPSILLCTDVASRGLDLPKITHVIEYDPPFSIEDHLHRVGRTARAGQDGRALLFLLPGAEEGYVEKLKQSQQMKKTTYENILAAGFGGKGWDFAATNYHLDVERWVLGDETALDRARRGFTSHIRAYATHIAAEKDMFNVRMLHLGHLAKSFALREAPGKLGKKKDPEKIKVNKDGSLDETQARKKMLDRSRKHVYNSGESAMGGYVLE
The following text describes a protein:
Function:
May have a photoreceptor function.
Sequence:
MAGRMKIVICLLRNDLRYRDNEVLFWAHKNATNVIPLYCFDPRHYKGTHQFGFPKTGPHRLKFLLESVRDLRTTLQSVGSGLVVRSGNPEDVVPQLIQQFGEGEVAAVALQEEATREELDVEAGLHQSCSKLGVQVKKFWGSTLYHREDVPFSPQGVPNVYTEFRKKVENRSHVRPPINMPKPLKGLPQGVEEGDIPVFSSFGLKDPGSDSRTAFPFQGGETTGLARIEDYFWKSDCIAKYKETRNGLIGSEYSTKFAAWLAHGCVSPRQIHAEVKRYEKERTENQSTYWVIFELIWRDYFKFVALKFGDKMFYLSGLLGVHKPWNKNKQWFDAWCKGQTGVPFVDANIREMAATGFMSNRGRQNVASFLTKDLVLDWRLGAEWFEQMLVDHDVTSNYGNWLYSAGVGNDPRQDRKFNMIKQGLDYDPNGDYIRLWVPELSGIKGGSIHMPWTLSSAQLNQAGVSLGETYPSPIVTAPEWSRHSKRPQSGRGGAGGSQGGGSQGGGRNQSGKGQRRNQGPPRGQQRGLDFYFSNPSQK
The following text describes a protein:
Function:
Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine. Can also mediate the transport of selenate and thiosulfate.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MKLLNYAFVYRRFLLVVFTVLVLLPLPLIIRSKEAECAYILFVIATFWITEALPLSITALLPGLMFPMFGIMSSTHVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALRMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIVEAVAQQITSAEAEAEATQMTYFNESAAQGLEVDETIIGQETNERKEKTKPALGSSNDKGKVSSKMETEKNTVTGAKYRSKKDHMMCKLMCLCIAYSSTIGGLTTITGTSTNLIFSEHFNTRYPDCRCLNFGSWFLFSFPVAVILLLLSWIWLQWLFLGFNFKEMFKCGKTKTLKEKACAEVIKQEYEKLGPMRYQEIVTLVIFIVMALLWFSRDPGFVTGWSVLFSEYPGYVTDSTVALVAGILFFLIPAKKLTKMTSTGDIIAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCQVSGLSSWIGSKLSPLGSLPVWLIILISSLIVTSLTEVASNPATITILFPILSPLAEAIHVNPLHILLPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNILGVAVVMLGMFTWIEPMFNLHEYPSWAPDIVNQTMP
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSEFILNEVYTEYLEDAQQLVSRANSPSDFNYAVNELIEDVAVNSSQIFHNNNLTTTFQILLNISELTSRSLGKLADLLQTCFRGACESALEALERSDSDIYSQVRTEVEVYGFLVQWLISALAHKVSTDDNSGGKGRSKKDVEVENLKRYIVGLMEASANIMDIQQLRAIFGTSQDHDTFAAMICRAAYRAIETEALGKDANVRDATFDVIIAGIKFQNQSNMAHSMLLQHLNYYEHLSEPVAELLALLYNRENESAVSETIILEVSQMHFSNTDSKAPKAIAMFLVKLSQLAPKLVLKQMAVLRRLLESDSYAIRNGIVDSCSQIVVSISTTGDDGEHYRSQIEGVLELVEERILDVSPYVRSRVLQLFSNVCDLEVRFNAHFQQTANMAVECLNDKSGLVRGRAAKLLQKLVTTHPFKALHGAQLNMGVWKDRLAGIEVEITDLEKSMPAEVNGAYLDPPSDDEGEHAAQNDVSENLEKLKKLQLTQTYYKDAIKFMTVMKRAFDQAEVLLFSKVKTEVMEMMDMFVLADAYNFEGASSGIRKMLHVIWTKGNSDEGKEVQARLLSAYSKLFFEAPLSIPDAEASMYIARNLISLTYGATLAELASLERLLCVAMEKGIINALVVRKLWQTFGYTQGAISRSQRRGAVIVLGMLAQADAEIINVGLETLLSVGLGAFGQKDLVLAKYACVALQRLGGDPKLKASMSSDSAVITALMSIVEHYTEDLEWFDVAAQSLNAIFILAESPEEVTSEIIRRKTISTFSEGSSGLRDIKLSQLLVVVGHAAIKLIVYLEAKELEFKRLKVMVEKAKSGEAGGDDDMEQIGGTSEDDFSEIITSVREREILYGDNSLLAQFGPLVVEVCSNNLKYSSETLQIAASSCLSKLMCVSPLFCQQSLPLLITIMEKSENPIIRSNAVIALGDMTICFNHLLDENTNYLYERLHDSSPMVQRTTLMTLTFLILAGQVKVKGQLGEMAKCLENPDKRISDLSRMFFTELATKDNAIYNGYIDIFSVLSADEELSDDQLKRVIRFLTSFVEKERHVKQLSDKLFARLGRCETEKQWKDVSFALGLLPHKNESIQGVIAEGFKVVGKV
The following text describes a protein:
Function:
Regulates carpel specification in flower development. Severe or intermediate mutation in DL causes complete or partial homeotic conversion of carpels into stamens without affecting the identities of other floral organs. Interacts antagonistically with class B genes and controls floral meristem determinacy. Regulates midrib formation in leaves probably by inducing cell proliferation in the central region of the leaf.
Subcellular Localization:
Nucleus.
Sequence:
MDLVSPSEHLCYVRCTYCNTVLAVGVPCKRLMDTVTVKCGHCNNLSFLSPRPPMVQPLSPTDHPLGPFQGPCTDCRRNQPLPLVSPTSNEGSPRAPFVVKPPEKKHRLPSAYNRFMREEIQRIKAAKPDIPHREAFSMAAKNWAKCDPRCSSTVSTSNSNPEPRVVAAPIPHQERANEQVVESFDIFKQMERSG
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Subcellular Localization:
Mitochondrion.
Sequence:
MTVRDALNQAMEEEMRADEKVFILGEEVGRYNGAYKVTKGLLEKFGEKRVIDTPITEMGFAGIAVGAALAGLKPICEFMTFNFSLQAIDHIVNSAGKTKYMSGGQIDVPIVFRGPNGAAAGVGAQHSQCFAAWYGSVPGIKVVSPWSAEDAKGLLKAAIRDPNPVVFLENELLYGVSFPVSDAVLKNDFVLPIGKAKIELQGTDVTIVAHSKAVGQSLEAAAELANKGIKAEVINLRSIRPLDMDTIITSVSKTNHILTVEGGWPMFGVGSEIAAQIMESEAFDYLDAPLVRVTGADIPMPYAANLESASLPQVDTIVGAVMKMMARK