lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes. Functions as a non-electrogenic Na(+)-independent transporter. Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments. Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation. May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids. Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine. Capable of transporting ATP (By similarity). Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers (By similarity).
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Domain:
Contains a N-terminal dileucine motif (DE)XXXL(LI) important for endosomal/lysosomal and mitochondrial subcellular localization.
Sequence:
MAIISEDDFRHTSNSTYRTASSSLRADQEALLEKLLDRPPPSLQRPEDRFNGTYIIFFSLGIGGLLPWNFFVTAQEYWIFKLSNCSSPAAGEEPKDSDILNYFESYLAVASTVPSVLCLALNFLLVNRVPIRVRVLASLTVMLAIFIVMTVLVKVDTSSWTHSFFTITITCMAILSGTSTIFNSSVFGMTGSFPMRNSQALISGGAMGGTLSAVASLVDLAVASDVTDSTLAFFLTADIFLALCIGLYLLLPRLDYARYYMKPVWPTVFSGEEQLPQDSPSPTSVAPGSSDPQTPPLGPILKKTTGLGFCIIYLFFITSLIFPAICTNIESLSKGSGSPWSTKFFVPLTTFLLYNFADLCGRQVTAWIQVPGPRSKALPGLALLRTCFVPLFVFCNYQPRGHLHTVLFQSDVYPVLFTSLLGLSNGYLSTLALIYGPKIVPRELAEATGVVMTFYMGLGLVLGSACSALLVHLI
The following text describes a protein:
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Sequence:
MSLENHRRHPISISPPKATTTPDKAATLIFLHGYGWSADQFNQHPPNGKSVAHHIHKSPSLQHVKIIIPEGLPNNWPNPGKHTWYNIDQPVPSAGDPSKIHEFGQHNSDVHDIEVSLDYFESLIDAEAATGTPPNRIIFMGDSQGSSILYLFLLTRRRAADLGAVITWAGFSATPLETIAQMQEKNGLSEGWAKNTVLHMLHGKEDVFVPLIRAQALMTALESYRARGQGFETLEWVVVDKLRHSLVEPVWPYIRRILERFSTETEAASKL
The following text describes a protein:
Function:
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MIFASSNRHKYEEFRRMLSDLIDLKFLEVDYLEPQGEDTREIVVTSAKWLSNYIREPFFIEDSGLFIEALNGFPGPYSSYVFKKIGNEGVLKLMNGVENRRAFFISVIALSYGRGIEVFEGRVQGTIAREVRGGGWGFDPIFIPNGSNKTYGELGDEKDRFSHRGASCRKLREFLMRFGSDRLP
The following text describes a protein:
Function:
Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine.
Sequence:
MLVMRPAQAADLPQVQRLAADSPVGVTSLPDDAERLRDKILASEASFAAEVSYNGEESYFFVLEDSASGELVGCSAIVASAGFSEPFYSFRNETFVHASRSLSIHNKIHVLSLCHDLTGNSLLTSFYVQRDLVQSVYAELNSRGRLLFMASHPERFADAVVVEIVGYSDEQGESPFWNAVGRNFFDLNYIEAEKLSGLKSRTFLAELMPHYPIYVPLLPDAAQESMGQVHPRAQITFDILMREGFETDNYIDIFDGGPTLHARTSGIRSIAQSRVVPVKIGEAPKSGRPYLVTNGQLQDFRAVVLDLDWAPGKPVALSVEAAEALGVGEGASVRLVAV
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MENADEYDHLAPKLRGKKEGTFAYYTVRDRWPKIVTGLVDQLAQKRASLIEKYGSEVESDIAAILEVFSKLRYEIMTDKPLCNLMDTQLDSEMWRNLLSDMRTAAMPDEVEDLTFFKGPWLFVECWLYRFIWSTFAKTIRLSEYDYFQDSKRKNFLDHLPQIEESAAFINKISAKDAPVHELFGINTILKMSLWGNRADMSLTGGDDHTLAMSSMSASSKLADFVLIDDVNDMIVKVLGPLKINANHETNRRIDIILDNSGVELTGDLIVAEFFISRGFADKVVIHGKAIPWFVSDVTKPDLDWTIEQLKNGENIGEESRALGEKLEKRMKSGQIVYQDHLFWISPHAYYAMEKEARDLYDDLKNSSLIIFKGDLNYRKLVGDRDWDLDTSFKTACRGFAPCPFMALRTLKAETVAGLSEESIAILLEKFEEDNTWMTSGEYAVCQLGGI
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKFEEFQKLTPKEKKKAMAELHDLRGPTYQIFKEKPESKTQLWNIFSPKIFYLIQYMDHFLRFINPHVFLGCVQFLQLQTSKENEALLGTRLFERLRKIGVPQEKIDQIMQQDNLNGKLSQVSELLRLRSRALVDYVQENLWTVEEAYQALIILFDQGEYERATEIVDNLYPCVEATEKLNHLRNGFLWARLNCKLIGLFKNNNNATACIEAIKDLLKQEDQIKYNFKQRADLLHAGVLVCFISDDTNAFLELFSGDQFLEVVHTIAPYLLYYYAVALLINQQFVGNTSLAQIGANASKSVMHFHLLNYVEEIIVKFQFDNAIKMVNDIATEIDKDFIVKSKKAIIINACKLYFFSTYIKILNGVQIKQFSNYLQLNEEETESWLVNAIRTLNINAKIDGDKIIVQKQDNNAQNTQLLKQLRDLQPKSNMLISNLQRIINIK
The following text describes a protein:
Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Sequence:
MSWSVLEALRKDPEILRENLRRRFLPLDMLERAIELDRKWREAVTELNSLRERRNEINRSIPRADPGEREELIRKAKEIGEEIERLEDVLEKLSQERDSILMSMPALIDDSVPIGPNEDYNKPIRFWGKPKVPRSKLDSFMEQTRGFNVEYELIDWEPLGHADELEVMLKQVDTVKAGQLAGSRFFYLFKDIVWLEQALILFALDKISRKGFIPVIPPYMMRRDYYLGVVDLNTFEDSIYKVEGEDLYLIATSEHPLVAMHAGDTFTEDELPRLYVGLSPCFRKEAGTHGKDTKGIFRVHQFTKVEQIVFSKPEESKYWHERLIENAEEIYRELEIPYRIVNIASGDLGASAAKKYDLEGWFPAQGKYRELVSCSNCVDWQSYRLRIKLDRKGRREFVHTLNSTALATTRTISAIVENHQREDGSVRIPKALRKYLEIFEQAPKEEIVPIEKILKE
The following text describes a protein:
Function:
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MGEEKEIRIIVLEDGEHLESVIRKIEKGWIVRFKRGSSLLGKKVKVFTSICPGNSLEWSEGKDHLAVYCQVECKEAGSFRYWFKIEDSEERGSGYFLVMPELKINGKCLPLDGIACQTYLTKLLGPLSEWKERLEVAHQTGYNMIHLTPIHELGISNSSYSLSDHHSLIKTIQSQDQKFGFEDVQALVGDLERSWNILTVQDVVWNHAAKNATWLLEHPESAYNCLNSPHLRPAYVIDRVYHEFGKQIGEGVWEHRGVPPVVDNIHHVNAIEYLLRAEVLPKADLHEFYQVDLKAMVNLFEVFIKQSSGPTTNPLDGEDVEIEQDLECRRFGNTVDFERSARIFNRHRGDAKSEEERVEKCVRSFEEALNNKNLEAARESWEVILAGLAAVMGGITYERIADNGPKKGLVSPENPLTTDYFLHLEADLGWKSEEKFAYDPEKSKFLMAFNGWVMSSDPMKNFALKESQVYLRRELVCWGDSVKLNYGNKEADSPFLWQYMKEYTQQAARIFHGLRIDNAHGTPIHVAEKLLKTAREVRPDIYVFAELFTGSEHADNMFVNRLGISSLIREAQSAHDSHEQGRLVYRYGGDCVGAFKQKSARLAPKSIAHGLFLDQSHDNPSPIHTRSPFDILPTAAMLTMASCAVGSNRGYDELIRDHIHVVSEKRPYASWCRPDQVSRSQGIIEGRNLLNKLHTWLAEHGYSQVFVDQMNSDIVGITRHNPRTHETVVVVSHTSFSKNYIDWPGGLKHIPIGGVLENVIFEMKLKKVQEEWGTEDPDVLIGLKNYEMEIRENVNLDNGTMFKVHDGYIELTNFPTGSVVGFKIRPSDEATKAFNMIHNSITPEQSEFDSALSRLTYQSFPNLLFHCESEDYATIQQGGYDVPNFGKFVYCGLQGLVPVLEKIRDDNDLGHPLCQNLRDGTWICDYIVGRLAKFEKLGEVSEAIRKFFAPLDHVPYYLRPCYFELLVSYIYGKIRKEALKRMAPQISSSSALVRHLAISTLSFLGYIPGAGLAPIPTSLQIEDQYPSSLAAGLSHFAVGIWRNWGRDTFIALPGCLLSTGRFQEARQIILSFAGAIRHGLIPNLLAEGIGARYNCRDATWFWLVSIVKYVESAPNGVGILEDPVRRIYPNDDSVYGEGEVQQMLIETIYEALDKHFAGIDYRERSAGPQIDEQMRDEGFQVTAGVSRTTGFIYGGNRWNCGTWMDKMGSSERAGNKGEPATPRDGAAVELQGLAYRALKSLKNWKEQGVIQRSGVSDEWTWGFWAQKIRENFEKEFFVDKDSYAEFVNRREIIKDSVGSTLGFTDFQLRCNFGIALAVAPDLMDPKKAWKALDSAEVLLGPLGMKTLDPTDWAYNGYYNNDDDGTDKKTAKGWNYHQGPEWLFVAGYYLQARLRIGDILGGSEKQYAIRQVQERLGNAYKHIISSPWRSLPELTNADGEYCMQSCAAQAWSVGCLIEACVKLNTIEG
The following text describes a protein:
Function:
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Subcellular Localization:
Cell membrane.
Sequence:
MASPGQIIFWSIISIIIILAAAIALIIGFGISGKHFITVTTLTSAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGAMGLVHEFKEGKDDLSDQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSIPEVNVEYNASSESLRCEAPRWFPQPTVVWASQVDQGANFSKVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENNIAKATGDIKVTDSEIKRRSHLQLLTSKASLGVSSFFAITWALLPLSPHLMLK
The following text describes a protein:
Function:
Catalyzes the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MSVQEWCHLSRQIKFRHDYLNVRNVEFGENMENNECTRFATLNVGTLSGRLLEMVDMMIRRRIEALCVQEIRWKGNESRWANGYQLVCSEGDGLKNGVAELAAANAKSMHPRLKIVVVLLAIATIVHIILDDGAFFSSLASFNFDYHTSIDTIADGTSSTLNESFVESLEVNGTSLCPVTPPGLVGKIRVWMDGPSYDQLEKLYSSWIDKGGHSYPRHCISRHKVAIIVPYRDRDTQLRIMLHNLHALLTKQQLDYGIYIVEQVSPGVFNRAKLMNIGYEEAIKDYNWDCFVFHDVDLLPEDDRNIYSCPAQPRHMSVAVDKFNYKLPYGSIFGGISALTREHIEKINGFSNDYWGWGGEDDDLSTRVSLAGYKISRYPADIARYKMIKHSHESSNKINKCRYKLMGKTKQRWMSDGISSLNYKVIRMEKRPLFTNILVDLLYEESITKLRKTFPSC
The following text describes a protein:
Function:
May be involved in iversification of muscle cell fates.
Subcellular Localization:
Secreted.
Sequence:
MLIAWLVLAATLSRSIRASTTISIPITTQDIIAGDVFFEILSPSELEYTYRLRPAKDFGSAFSERLEGVPLVITDPPGACQEIRNARDLNGGVALIDRGECSFLTKTLRAEAAGALAAIITEYNPSSPEFEHYIEMIHDNSQQDANIPAGFLLGKNGVIIRSTLQRLKRVHALINIPVNLTFTPPSKINHPPWLGW
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MCPASTALSMNTDIMRTTNQDTDDDGGLGCFRASATPISTSETEREISQTAIMEELMFGQPDPECGPRDMTGDHEAEDRTHMSDEVQLQAPRRRNRRVRCDPVKVPTVVSVEMPSIRSAVQHLLNKQERTLLNFGLLAGTVNEDNADSTTKSNSYICVECGQCFSYEVAYVEHRKNHKPFIVEAGTLGTAGSATKMSSLDQKRAGREFMCSECGKTFIGKSNLIVHQRTHTGEKPYGCIFCGKHFGRSSVLRKHERIHTGEKPYTCLYCGKGFSQNSGLKNHERIHTGEKPYACAQCGRRFSQSADLMVHYRTHTGEKPFICVECGNSFIRSSDLVIHQRTHSGIKPFNCTECGKSFSQRSQIIRHRRTHTGERPFTCDVCMKSFILSSELKKHHRVHTGEKPYKCKECGKSFRHCSNMSRHQKMHVDILAT
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Sequence:
MFRIRVLRHVVRFASSSSTVASKRLTRHFCSQTLSTSLSSEAAAKYEKKSPTEHVLLRPDTYIGGVAMRESQFVWIRNSETRRMFTKEVSYPPGLLKIFDEILVNAADNKSRDPSMNRLEVWLDRETSRIAVWNNGSALPVEIHPTEGVYVPTLVFGSLFTSSNYDDNEIRTVGGRNGYGAKLCNIFSDEFVVEAVDSRTKRKFKQRWYHNMREFDEAVIEDLTNQQLSDYTKVEFVPDLKRFHIDKLSEDIIDLIGKRVFEVAATLPSDVQVFFNGQKCDVDGFEDYVRMFNDSNPSSFLFLHPTSRWHVGVAKRNTFSGEGIVTLPKVVSFVNNINTEKGGSHVDYVMDKIVNVMKPLVDSRLGDPSKSVKPATIKNNISLFINCLIENPSFESQTKETVTTKPKQFGSSFDCDSEKISKWAETSGLLDEIVDEVLNTKKKKISSKRANSSSVRDIVKLEDAEWAGVPGKSEKCTLILTEGDSAKALALAGLEILGRQTYGVFPLKGKLVNVSNLDDIRASKNEEIGKIVRILGLNFNEPTPSKESIRYGRLLILTDQDEDGSHIKGLVINFIHKFWPSLIQSGEFIKSFRTPLLKAKKGNEVVPFFSLNEYRKWAETIEGKWKVKYYKGLGTSTSNEAREYFRNLDHHTVNFNYAGSSDDDAIRMAFDREKSDERKRWIRGSDEVSTTEDVEKTELNYEEFVNSQLMQFGMADLKRSIPSLIDGLKPSQRKILWTLLKMDETTEMKVSQLAGAVAHRQSYHHGEESLVRTIVRMGQTFCGASNMPLLQPIGQFGTRHEVRVIMITPPHFLRFSEKRNNLEKNGKCHSIQHPKKPICPQNQVPVNPTTRLLFPIADDDLLEKKVEEGITVEPNTLCPIIPLILVNGTEGIGTGWSTKVANRNPVDVIDMIRRKIDLSSLVVNEIPPFYEDYKGKIEIVTPTKFISTGKIKISRPERKNASTFSVEISELPIGVWTSKYKEKLSNILEKLPITEFSERHTEKQVNFRLIFDRKKAARFLQKSNSDLLNYFKLRTSITENRVLFDRNGQLKEFGNVSEIANEFFEIRKDLYQKRLEIQKRECEAKLKYVNNQVHLYYYMNFIELVTNGTFELKSMDRESLELKLEEIGFEVDSMKTENSKKSNYGYLLEMPLSRLTLDEMNRLKERKSRRNLELKAAESADWKSTWHSELDKLEESIKKTRKEYLAS
The following text describes a protein:
Function:
Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cell membrane; Lipid-anchor.
Sequence:
MCSAPNGRKNRPRSAANIFQIGKSSVRDPERRESTESARRAQRAMDDCRTTVQEFNTLVALHREQVISIGENTTDCPSLRAQMHKTRVKGCAVAQAAYQNLIAISGPEDGEIHPEICRLFIQLQCCLEMYITEMLKSMCLLGVLQLHRKGNDMCPELNMDCRVDESSDVPMLEDRSSSPMDFPQDSWVVCADIENIESDMREMRNLLSKLRETMPLPLKNQDDSSLLNLTPYPLVRQRKRRFSGLCCLVSG
The following text describes a protein:
Function:
Liberates mannose from p-nitrophenyl-alpha-D-mannoside in vitro.
Sequence:
MIDQTTLGHGLIKSQFNKVPRVGWQIDPFGHSAVQAYLLGAEIGFDSMHFARIDYQDRANRKNDKSLEVIWRGSRTFGSSSQIFANAFPVHYSPPEGFNFEVSNDFEPVQDNNLLYDYNVEKRVNDFIGAAMTQDGRVNALYSTPSIYMDAKNAANVSWPLKTDDYLPKDAYWTGFFTSRPALKGYVRMLSGYHLAARQLEFLVGRRSSGPSTYRLGDALGLVQHHDALTGTAKQHTTNDYEKRLAIGASEAEAVVDNALSCLVSKKPGGQCSLPVLNFNQCPLLNISFCPATEEDIPDGKSLVTDSNFVIRDSSGHTVEAQLIDLDNVTINLRNFYVKAYLGLSPQQIPKYWIVFQVSLPPPGWNTYFISKAATEGESKTSFLSTLGDPQNDTIEVGPGDLKMLFSSTSGQLVRMFNSKTGVDVPVQQSYLYYSSSIGGTDDSPASNLYIFRPNGAHPTIVSRKVPLKVVRGPLVDEVHQQFSSWIYQVTRLHKDKEHADVEFTIGPIPTDDGVGKEVITQMTANMATEKTF
The following text describes a protein:
Function:
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVSARAPFRACHSLGQLNQFAAGQRPELGARAILVIHFTCSRLSGRTPTNSPPGLSPLGPFQPSNDMMLKFYSYYKQATLGPCNIPRPGFWDAVGKAKWDAWNSLGDMAKEEAMQAYVDEMKLILEGMPMTDEVEELLKVLGPFYELVDERKKITQISDLSTGLGTMLNSAPSASVTKSIIRNMEMNGTLETRPTKLRPNQELLSEEEDDDDDEEEDEEDGESAASQPKKKSSTRRHKLPAPDGKLANGGSHLTNGNHSEAAPNAEDSAETPASQRPLNGLHADPRTNNLTSDSDSEVYCDSVDQFGQDESPEHHHSVDELDEEELQDAPPQPVRCGGEEGQGGGNASQTPRLHADRAGGSGRRRPGSRSPGHSAGPPMPTHSGRDGAGGRRGGAGTPSESLNEQIVAALARLQEDMQNVLERLHTLEALTASQARSAALSPTFLSPQGKKRSPKPSWWPFDISPAGVAFALLWPFVVQWLIRLYLQRKRRRIN
The following text describes a protein:
Function:
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Miscellaneous:
MISCELLANEOUS: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQTKTKYGKMKQIASNLKLPDYRYEQLTKAIFHQRIDNFHDMHILPKALRIALVNEFGKNVSSVTPIFSQDSKQAQKLLFELTDGERIEAVGLKYKQGWESFCISSQCGCSFGCRFCATGSAGFKRNLTADEITDQLLYFYFNDHRLNSISFMGMGEAFANPELFDAVKILTDQNLFGLSQRRITISTIGIIPGIQRLTKEFPQVNLAFSLHSPFESQRSDLMPINKRFPLNEVMKTLDEHIIHTGRRVFIAYIMLEGINDSKEHAEAIIGLLRNRGSWEHLYHIDLIPYNSTDKTTFKFQSSSAIKQFCSTLKKASISATVRTQFGSEISAACGQLCYENEL
The following text describes a protein:
Function:
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.
Subcellular Localization:
Apical cell membrane. Basolateral cell membrane. Cytoplasm, cell cortex. Nucleus.
Sequence:
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MVAWRAAGLNYVRYSQIAAQVVRQCTKGGANVKKPQATLKTTAWENGKMVSKSQ
The following text describes a protein:
Function:
Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (By similarity). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination of phosphorylated cyclin-D1 (CCND1) (By similarity). The Cul7-RING(FBXW8) complex is however not a major regulator of CCND1 stability during the G1/S transition. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity).
Subcellular Localization:
Cytoplasm, perinuclear region. Golgi apparatus. Cytoplasm, cytosol. Note=Localizes to the cytosol when phosphorylated at Ser-86, promoting IRS1 ubiquitination.
Sequence:
MDDHNLEEFRRHWQEELAQSQALRRRRRLEAGERRSPRRPEAGARGEPASGYLGLAQGLLEGAGRPPAPRPGRGGDRKDTSSRSRSPPDRDATEPEPLVDQLIRDLNELDDVPFFDVRLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCRQEGHLPHSRFSDYTCWKLILQECLAKEHTLRANWKNRKGAVSELEHVPDAVLCDVRSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESESEEEDPGMQPYVSFVRINSSLAVAAYEDGILNIWDLRTGRFPIFRFEHDARIQALALSQEKPIVATASAFDVVMLYPNEEGHWHVASEFEVQKLVDYLEIVPNTGRYPVAIATAGDLVYLLKADDSARTLHYVYGQPATCLDVSASQVAFGVKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNIRDSPPNLMVSGNMDRRVRIHDLRSDKIALSLSAHQLGVSAVQMDDWKVVSGGEEGLVSVWDYRMNQKLWEVHSRHPVRYLSFNSHSLITANVPYEKVLRNSDLDNFACHRRHRGLIHAYEFAVDQLAFQSPLPVCRLPRDIMAGYSYDLALSFPHDSI
The following text describes a protein:
Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function.
Subcellular Localization:
Secreted.
Sequence:
MYRGLVLLFLVLVLETRWSESSCQQSESQRSVSSESPSFRMSTHNLLKRYNDIDYDSFVGLMGRRNAETDDIPPQRKREMHDIFVGLMGRRSAEPESGRQWRKEYPEPSGGIFFNKCKLRFRRGL
The following text describes a protein:
Function:
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Sequence:
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
The following text describes a protein:
Function:
May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Transcriptional activator involved in the activation of a subset of sugar-responsive genes and the control of carbon flow from sucrose import to oil accumulation in developing seeds. Binds to the GCC-box pathogenesis-related promoter element. Promotes sugar uptake and seed oil accumulation by glycolysis. Required for embryo development, seed germination and, indirectly, for seedling establishment. Negative regulator of the ABA-mediated germination inhibition.
Subcellular Localization:
Nucleus.
Sequence:
MKKRLTTSTCSSSPSSSVSSSTTTSSPIQSEAPRPKRAKRAKKSSPSGDKSHNPTSPASTRRSSIYRGVTRHRWTGRFEAHLWDKSSWNSIQNKKGKQVYLGAYDSEEAAAHTYDLAALKYWGPDTILNFPAETYTKELEEMQRVTKEEYLASLRRQSSGFSRGVSKYRGVARHHHNGRWEARIGRVFGNKYLYLGTYNTQEEAAAAYDMAAIEYRGANAVTNFDISNYIDRLKKKGVFPFPVNQANHQEGILVEAKQEVETREAKEEPREEVKQQYVEEPPQEEEEKEEEKAEQQEAEIVGYSEEAAVVNCCIDSSTIMEMDRCGDNNELAWNFCMMDTGFSPFLTDQNLANENPIEYPELFNELAFEDNIDFMFDDGKHECLNLENLDCCVVGRESPPSSSSPLSCLSTDSASSTTTTTTSVSCNYLV
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MDSDQVSENSAMAQPYHNDDDSGRELSAEYGSSRQEDHQHHADLQWNSINRSLRHHGLQPISFLSQDSVEIPCQNIIIMDNAMSAILRNNLSSLMDDCDRRQALIQELITTTSNFQAKSRNDNSNTEKLHMEITQLRMQLEDERIKFKEINEDRTLEIHQYTDEIETLRLSRDNYHSKYSQLLRKLRHNEKESDQLRQQYNDLIDKEEKRIDRHNEIFRLIKKKSPRLYNALDRATLEIMDAYENVIEKLKMELEIMRAETNEADSNLVGLRTDIDVLSHSSNPRAVLETGETAEIQEKANKITHQTVAKQEKKFKELQQKLKAADKQIHELKSHSKNLDVDNVSMKRELQDRPSLREWNKLKRHANKLEEILQENDISIKDRKKNQHTQDTVEDTNLQNLENQINKMSLLKCRDNIKKICTFMKIDDFNRIWPHLDGMASIADTYRLMDKLIRAIIELIAESELPDVNEGIRLQGLDNLCEENWHHIIPTLKAWIKQLHGLQELQQSINRLASTLLPWQRDDIDIFKDKALTVTEINAAVDALTRHGEDNGINIQESESDPSHLKMLQTVVQHFQKLFDVKTLSGVFTRMNDIYVKLNETYNILHSLRETLGLEENCLPRTIVAAVSKLVQIHDNASYNQIQKLLGVNDLKE