lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Subcellular Localization:
Secreted.
Sequence:
MQARVFLLLLGVILLGMMGPMVSAQDGKAGSCPDVNQPIPPLGVCKTTCATDSNCPDIQKCCKNGCGHMSCTRPST
The following text describes a protein:
Function:
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Sequence:
MASCLAASSSFGSRLHRTVCVLCPGVARGFSSSSIGCWRQDSPSDRFSGTARGARGGVIGEKAPKEKVDAPEALPNPPKSKKARHRPLLRPPSHPVQTLPSSSAPTPQHTPHTPSLPEAVAHKPHGPWQPTKKLTFSAMAGLRALHTLDPERFSRAFLSRKFGISHEAVTRILKSKFRGQKIDGIEGLDGVMGLLNEEASEEAPPGGLGQPDLRGTKWDKAPETSERVSPVPAIMRAYRQSRRSR
The following text describes a protein:
Function:
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.
Sequence:
MDPALAAQITEAVAEKMLQYRQDKSGWKICREGNGVSVSWRPSVEFPGNLYRGEGIVNGTLEQVWDCIKPLAGTLRDKWDENVAGFEIIESITDTLCVSRTTTPSAAMKLISPRDFVDLVLVRKYEDGTISSNATNVEHPLCPPKPGYVRGFNHPCGCFCAPLPGEPGKTSLVTFFQTDLSGYLPQGVVDSFFPRSMAGFYANLQKAVKKFYG
The following text describes a protein:
Function:
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Subcellular Localization:
Mitochondrion.
Sequence:
MWKSVVGHNVQVKVSAEGDDWETDPDFENDVSEQEQRWGAKTIEGSGRAEHISVTELRDRVSQEHELVKRKEQEQGPRAAYGYGGKFGVEKDRMDKVAVGHSYVAEVEKHSSQTDAARGFGGKYGVQKERIDKSAVGFEYKADVEQHASQRDYSRGFGGKYGVEKEKVDKAALGYDYKGETEKHQSQKDYAKGFGGRYGVETDRVDKSASSFTDMESPASSYQKTKPVEASSVGAGSLKARFENMSKASDEENRRRAEEERARRQAREKREQEEARRKQQVRPPHLRQAQHCNIDLPTPLTQLTQEPPVPEEEGYEPEYEEPPQLPPRSEEPPQLPPNTEEPPQLPPRSDEPPQLPPRSDEPPQLPPRSDEPPQLPPRSDDGLEQEGEGEYEDVGGFQTASGMVPDGVPRSHINKHEKNEALTQENDYEAIPAGVSAVAIYDYQGEGDDEISFEPDDIITGIEMVDEAWWRGTCRGRYGLFPASYVQLM
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
Sequence:
MESKYNYFKRDISWLSFNYRVLLEALDEHLPLYERINFISIYSSNLEEFYKIRVADHKAVASGATESDEETVQSARELVEEINHEVNRQLDDRVRIYEEKILPALRKNHIIFYQDRHVEPFHQQFIKDFFREEIFPYLQPVPVSKDKIVSFLRDNRLYLAIRLYPKENRNPANRQPFYFVMKQPYAKVPRFIELPPRGDNYYIMFTEDIIKANLNLIFPGYDVDSSYCIKISRDADILIDDTASSADLVAQLKKKVKKRKIGDVCRFVYDRAMPQDFLDFLVDAFRIHRDELVPGDKHLNLEDLRHLPNPNKSLRRIEKPQPMKLNILDEKESIFNYVAQKDLLLYYPYHSFEHFTHFLYEAVHNPETREIMVTQYRVAENSAVINTLIAAAQNGKKVTVFVELKARFDEENNLATAEMMQAAGIKIIYSIPGLKVHAKVALVRRRGLNGEKIPSYAYISTGNFNEKTATLYADCGLFTCRKEIVNDLYNLFRTLQGKEDPKFTTLLVARFNLIPELNRLIDREISLADQGKGGRIILKMNALQDPAMIDRLYEASEHGVQIDLIVRGICCLIPEQSYSRNIRVTRIVDSFLEHARIWYFGNEGHPKIYMGSPDWMRRNLYRRIEAVTPILDPDLRASLIEMLHIQLADNQKACWVDDKLQNVFKKRASGTPAVRAQYDFYEWLKKDIVTEM
The following text describes a protein:
Function:
Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses.
Subcellular Localization:
Cell projection, dendritic spine membrane; Single-pass type I membrane protein.
Sequence:
MCGQRRPAAPASSLGSFGRASRGGGIGSSGGRALQPGLGDTMRRVLRLLLGCFLTELCARMCRAQERAGHGQLAQLGGVLLLTGSNRSGAASGEAGEGVGGSDAPPTRAPTPDSCRGYFDVMGQWDPPFNCSSGDFIFCCGTCGFRFCCTFKKRRLNQSTCTNYDTPLWLNTGKPPARKDDPLHDPTKDKTNLIVYIICGVVAVMVLVGIFTKLGLEKAHRPQREHMSRALADVMRPQGHCNTDHMERDLNIVVHVQHYENMDTRTPINNLHTTQMNNAVPTSPLLQQMGHPHSYPNLGQISNPYEQQPPGKELNKYASLKAVADKVNDDFYTKRRHLAELAAKGNLPLHPVRVEDEPRAFSPEHGPAQQNGQKSRTNKMPPHPLAYNSTANFKTWDPSDQSLRRQAYGNKGKLGIAESGSCDPLGTRTQHFPPTQPYFITNSKTEVTV
The following text describes a protein:
Function:
Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone.
Subcellular Localization:
Cell projection, dendritic spine. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Peripheral membrane protein. Postsynaptic cell membrane.
Sequence:
MNSQKPQHLAMTDTVFSNSSDRWMCPNDRSMALHTSEKEQLPTGWSVHPDQPAGSRKNEELTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGILGSSCVVCEDCKKNVCTKCGVETSNSRPHSIWLCKICSEQREVWKRSGAWFFKGFPKQVLPQPMPVKKSKPQQPPSEPSSSEPPTLEPKHHPRAPSRGPGEAGLPGEPGPEPAAASGRGSHGPPARRASEARMSSGGTDYAGRDSEGRDYGPGGAAGADASRSPAGLRRANSVQASRPSQAPSQSAAAQPGPPGPPGASRPGPNTAGRFPDQRPVQGDLAQGEPAYPSAAAIPRDDRAGDAASYPSAGAKEDRAARRTGAYSQAVAAPQPAAAPARQQQPPPEEDEEEANSYDSDEATTLGALEFSLLYDQNNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQKKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIVRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGITAKGERLKHWYECLKNKDKKIERWHNLQNENHVSSD
The following text describes a protein:
Function:
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSYPLEEVNKRRTFAIISHPDAGKTTITEKVLLYGNAIQTAGSVKGKGSAAHAKSDWMEMEKQRGISITTSVMQFPYNDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDSAKGVEERTIKLMEVTRLRDTPIITFMNKLDRDIRDPIELLDEVENVLKIRCAPITWPIGCGKLFKGVYHLAKDETYLYQSGQGSTIQAVRVVKGLNNPELDVAVGDDLAQQLREELELVQGASNEFEQDAFIKGELTPVFFGTALGNFGVDHFLDGLTQWAPKPQSRQADTRTVESAEEKFSGFVFKIQANMDPKHRDRVAFMRVVSGKYEKGMKLKHVRIGKDVVISDALTFMAGDRAHAEEAYAGDIIGLHNHGTIQIGDTFTQGETLKFTGIPNFAPELFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPLLNNDLIVGAVGVLQFDVVVSRLKTEYNVEAIYENVNVATARWVECADEKKFEEFKRKNEQNLALDGGDNLTYIAPTMVNLNLAQERYPDVVFYKTREH
The following text describes a protein:
Function:
Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor.
Subcellular Localization:
Golgi apparatus membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus.
Sequence:
MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLPTSQRFPSGLHRAVSDQGHLDVVHAPPHQARALVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQEYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQLGHNIKEMKQNGDSLVESILRSWFSFISPPSESEKAISSVLSLLRKKDRL
The following text describes a protein:
Function:
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MFHSCLESTVAVEKFDAMLIPDLQAALRSHMAPPVWTLVLLVGAAWGQGHMPQPVRKQKVPDGKPVARSSRDDSILTHCDFEDDSKPLCDWSQASTDDGDWTPASGPSLSGTGPPGGYPNGEGKYLHMDSDTFHQGEVARLRSPRIWEQGPLCVHFAYHMFGLSWGAQLRLLLLTGPKGKIPRLLWKHSNTQSPSWMPTAVTVPRRSTLPSQLIFEGRRGSTAYLDIALDAISVHRGFCNPICMMQMCDFDTPNDLCGWSWIPTASGAKWVQKQGSSGVQNVGPEEDFSSPGCGFYMLLDPKDAKPRQKCVLLSPLSRSSGCLTLSFHYTLYGQSPGAALMVYASVLGSIRKHTLFSGQPRPYWQSVSVSYTGQGQIQFAVVGVFGVVPEPAVAVDAIVIAPCGESFPECDFEDDARPFCNWAQASGNGGHWARGSKNQSLQGPGPFGASLNGESHYIYLQPGKFSQAGQSFRLMSRPFCTPGAICVELSYHMYGFGEGAKLRLLLESPAGSSPTSLWHCVGSQSPDWLNTSITIPSGRQQPIQLILEAIRGTNSAFVMAVGFIFINHGTCRGPAPTVLPSKSPVPLTGPSETPVFTGKHMATTEKPTVPSEISTIPTEKATVPTEKPTVATEKPIVPTEKPTVPTEKPTVPTEKPTVPTEKPTVPTEKPTVPTEKPTVPTEKPTVPTEKPTVPTEKPTVPTEKPTVPTEKPTVPTERPTVPTEESTVPTERPTFPTERPTVPTERPTVPSERPTAPLTPQPSPTLVPTEPTVLAMPLGAPSMPMTAVTLASTEGPRPTPASCPPNAHYESCACPASCQSPKPTCEFVCQPGCVCNPGFLFNDSRCISASSCSCMYNNNYYKPGVEWFSPNCTERCRCWPGSRMECELSQCATHTVCQLKNGEYGCHPYGTATCFVYGDPHYLTFDGRHFGFMGKCTYILAQARGNLTEPFFRVTAKNEERGQEGVSCLSKVYVTLPDTTITLLKGRRTLVGGQQVTLPAIPSKGVFLAPSGRFVELQTAFGLRVRWDGDQQLFISVSSTYSGKLCGLCGNYDGDSSNDNQEPDGSPERDDEELGHSWQMVEDEDVECQKNQATPPSCTSALLNGLSGPEFCGRLADSHGTFEACLPHLGASPFFESCMFDLCNFQGLQLMLCAHMAALTETCQDAGYVVKPWRGPQFCPLACPPNSHYTLCAKVCPDTCHSGFSGMSCQDRCVEGCECNSGFVLSGLQCVPRSQCGCLTPGAGYFKIGQQWFKPGCRQLCICEGNNRIRCELWRCQPQEVCSLQGGIYGCHAQGTGTCTVSGDPHYLTFDGALHHFMGTCTYVLTQLCLVRSLENTFVVSATNEFRSGNLEASYVKAVHVQVFNLRISLIKGHKVVLDGRRVALPLWPAHGRVSIRPSGSFVLLYTDFGLQVRYDGNHLVEVTVPSTYAGRLCGLCGNYNNNSLDDILSPHKRPVGSSVQLGISWKSNEYSEPGCFVGGAGGQPSRCQEKEAADTWNKNCDILMNPVGPFSQCHEVVPPHSSFASCVYGQCGSKGDPLTLCRSLQAYASLCARAGRAPDWRNSTFCPLKCPSGSSYSRCANPCPVTCFSLTTPKDCPAALPCAEGCECQKGHVLSGVSCVPLSQCGCTDQWGSYHPVGESWFTDNTCSKLCTCSTHNISCLQTACKPSQMCWPLDGLMRCRAADMGVCRILEESNYVSFDGAYHALGSTCTYVLVKVCHSTMDLPFFKITGKNGEREGQTSTFYLRQLNVNIFGFLVTLQQGHRVLINGTQVSLPLTSQIRGVSITARGAYTVLSINIGVQVKFDGNGFLEIKLPRAYYEKVCGMCGNFNGEEEDELMMPSDELAENDTQFVDSWRDKESDPKCQQDEQTVTPTEQQEKPITDCRPADLVTAQKECEAAFHAPAWAECATRVIVKPLLLGCTYKLCEFGGLNHLLCEALQAFGAACEAQGLKPPIWRNSSFCPLECPTYSTFTTCVPACSPSCQDPEGWCKGTEVPATCKEGCVCQPGYVLSEQHCVPWSQCGCKDAQGGLLPVGKTWLSHGCTQRCVCKAGAIQCQPFTCPSGSHCQPDATSTDTCAPDKSEQCSVFGDPHYRTFDGLSYRFQGRMTYTLVKTVDVLPDGVEPLVVEGRNKMIPPFTSIFLHEILVMVYGYTIQLQTNLELVVNNQKMAIPYKVNEHLRVTMRSHRLYLITNFELVVSFDGRNNAVISLPSMYEGLVRGLCGNYDKNRRNEFMLPNGTLTQNLNTFGNSWEVKIKEDLARVSRAIPEEEDGEEELGFQVTECSPEQLELRNSTQACGVLVDPQGPFATCHQTVAPDPFHEHCVFDLCAAWDPRQREELRCQVLSGYAIICQEAGAALAGWRDHTHCALVCPANTVYQSCMTPCPASCANLAAPGDCEGPCVEGCASLPGYVYSGARSLPLAHCGCTHNGIYYQRGDRFVTEDCSQRCICASSGVLLCEPFSCRAGEICTLGNFTRGCFRESPCLRNPCQNDGRCQEQGPHFTCECELGYGGDLCTEPWDVPPPEKPEVFALVAILLGMLVPVIVVVPALTRECVSRKRRRRRKEETHSQNGDRLADADYVPRRAFKVTQF
The following text describes a protein:
Function:
Catalyzes the oxidation of carbon monoxide to carbon dioxide.
Sequence:
MIPPRFEYHAPKSVGEAVALLGQLGSDAKLLAGGHSLLPMMKLRFAQPEHLIDINRIPELRGIREEGSTVVIGAMTVENDLISSPIVQARLPLLAEAAKLIADPQVRNRGTIGGDIAHGHPGNDHPALSIAVEAHFVLEGPNGRRTVPADGFFLGTYMTLLEENEVMVEIRVPAFAQGTGWAYEKLKRKTGDWATAGCAVVMRKSGNTVSHIRIALTNVAPTALRREGGRSRLLGKAFTKEAVQAAADAAIAICEPAEDLRGDADYKTAMAGQMVKRALNAAWARCA
The following text describes a protein:
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.
Sequence:
MSHIEENIRYSGAANEDGEDAQRKAQEREAKKAEVRKRLEEAGQKKQKKGFLTPERKKKLRKLLMIKAAEDLKRQQLLKEQERVKILAERTIALPNVDTIEDKAKLEAIYNDMFARLCSLEEERYDINYVTTETETTINQLNIEVNDLRGKFVKPSLKKVSKYDNKFKKMAEAKKDDNSKNLRNNLKTVKKESVFTQLSNQKKSEKPEWSKKNKEEKKEEVVPEPVAEPVQEEEAEASEEEDEEADE
The following text describes a protein:
Function:
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
Subcellular Localization:
Lysosome. Melanosome. Secreted, extracellular space.
Sequence:
GPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSGKSSTYVKNGTTFAIHYGSGSLSGYLSSQDTVSVPCNSALSGVGGIKVERQTFGEATKQPGLTFIAAKFDGILGMAYPRISVNNVVPVFDNLMQQKLVDKDIFSFYLNRDPGAQPGGELMLGGIDSKYYKGSLDYHNVTRKAYWQIHMNQVAVGSSLTLCKGGCEAIVDTGTSLIVGQPEEVRELGKAIGAVPLIQGEYMIPCEKVPSLPDVTVTLGGKKYKLSSENYTLKVSQAGQTICLSGFMGMDIPPPGGPLWILGDVFIGRYYTVFDRDLNRVGLAEAA
The following text describes a protein:
Function:
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation (By similarity). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The polyhistidine repeats act as targeting signals to nuclear speckles; The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance its ability to phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).
Sequence:
QPSISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRWMDRYEIDSLIGKVEQEWVAIKAFLNQAQIEVRHDTEMKYYIVHLKIVDFGSSCQLGQRIVEVLGIPPAHILDQAPKFFEKLPDGTWSLKKLHNILGVETGGPGGRFKDLILRMLDYDPKIQPYYALQHSFFKQETGIAGHPTYQFSANTGPAHYMTEGHLAMR
The following text describes a protein:
Function:
Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads. Required for the development of anterior tissues during late embryogenesis. Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors. In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die. Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister cell apoptosis. Also promotes apoptosis of I1 pharyngeal neuron sister cell. Plays a role in locomotion and fertility. May play a role in resistance to heat and oxidative stresses. May cooperate with the transcription factors vab-3 and ceh-32 to repress transcription factor ets-5 expression in non BAG neuronal cells.
Subcellular Localization:
Nucleus.
Sequence:
MLPDSEGQKLKTFLLGTGTTLDPSLDPTGNSNFSMATTSDSSTIWTALPASQPGDKDIPTVDLAAISEAYGSTSSTTSLTSSVTSQYQYNSYPQYAMYTSANPANYYQQVTANLRAGTTAFPYSLTTPSYYGSYPVDYTSAAAAYQNPYYTNLRGGTAAPYYNPLNATTAAAYASVASSVLGTDAVNLGTSSDGSTGVPSTVTSFSLKEKKPKVSKKKKTGSCSPGDETYARVFIWDIDDIAVISRNYLASVTHTNEFYARAANSVSHLMERIALNNFADVNEFLEGDITNIEDAVVDETTMDSGPIDNLRGLDVMRRVAPKYSAFRQFYTENSTKNDVAGFKQEQNGFNFELLERVGFGAREATELYQSAIQLQTLPNFGQRWPCAQRCMDLVVEKSKLSAEKYANVVLSNDGLVLGAAQLMISGLNSSVPVENIYSISKQGKESVFEKIQSRFGKKCSFICITSGDTANSAKRLNIPVWPLNSNTDLDKLYSALDNFLLGG
The following text describes a protein:
Function:
Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
Subcellular Localization:
Mitochondrion.
Sequence:
MNGVSRHLRASSLLSLIRSYGGINSVCRFSSQSDGFSGGRFREQVPVSGESANNSGLSNTGRIGSSPEPNPSTLRTFGDMKAGLLNRGVNGFSAPNAPPTFKSSLRSRLPNSLPDQFGQTNPGLPNTGGSGFSAPSLSSYENFTQSSSLLKENSRSGGKSSDLDFVREVIEDEGRRTAGIFSHFQRPNLETNADIIHIKMLRNNTFVTVTDSKGNVKCKATSGSLPDLKGGRKMTNYTADATAENIGRRAKAMGLKSVVVKVNGFTHFGKKKKAIIAFRDGFTNSRSDQNPIVYIEDTTRKAHNGCRLPRKRRV
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MKKELFGKRLTAFYNSLIFNKKDSWGNSDAVVIHSQQQENPNSLSSQFYLWLMGEKHDDTTVIFTPIGIFFFCTQKNYSKIRSLSCCATVMSKQPVSVQLKAKNDEGFAFIDSTIRQARVIRNSKGFTGVFDDDCNWPFVVGYIEGEYPKSKFFWNCMNDLEPKKYKVITVDSGINKMIHAADKPISGRELEFLQSLFTTFCPEDEKQLFFRGNQPGLLVKEKNDLESKFGRVGLSEKRRSNLGSEFDKTRLFCGDKSVSGVDDLTKNDLDFLEMLGSIERFSLPREERDKYKVANMSRDHKAGNKNGDQVFKSGSSILDGRKDKLKEISKHVDDVFKFGSSKLDAKDFKSKTFGERKKDVDQLFQFGEQCKIGEKRGRNNQPQLVMEENKGTKDVEQLTEKITAFYSSWRKYKEEKWGKADVLVITSPSVAPVEDWSRSFLVWLLDGEFLDTTAVFTDTGIEFLCTKESFFRLRTIGICMTKIAKLTVSVQLKKRGEQCVDWLKKTLRQVNTAAKSKPNWCPLVVGCIFGESGEIEVLSRSRMFEVAYVNNALTDLLEQGNFVKAERFAAQQSTLPKQFQMLSLGTRGSANTANAVSFSELAKIRSMDDNSYLSEELLRDAKTPTDGRVDNGGPVEQTKPEENKEDNSSRKLADKMMLLDIKEGDVETSITEDSAEENPLCMLFNDENSPLLQVKERGEQSGPTAEGGIDYSVQPTGVIDAASESSLPDDNNGISRKDSVGSDDDWTLVEMECQGKETEVAERVSWGRWFMGKTGKSFGFKDEVTDEAPSKRTKADP
The following text describes a protein:
Function:
Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747, RseA and RmlA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates the proteolytic activity of the proteasome. Is a major regulator of the oxygen-dependent replication switch since PknB activity is necessary for reactivation of cells from the hypoxic state. Shows a strong preference for Thr versus Ser as the phosphoacceptor. Overexpression of PknB alters cell morphology and leads to cell death.
Miscellaneous:
MISCELLANEOUS: Overexpression causes major growth and morphological changes that indicate defects in cell wall synthesis and possibly in cell division.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Localizes to septum and cell poles. The localization of PknB to the cell membrane is essential for cell survival.
Domain:
The intracellular kinase domain and all four extracytoplasmic PASTA domains are essential for PknB function and cell survival. The PASTA domains interact with peptidoglycans and are required for PknB localization.
Sequence:
MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Membrane; Peripheral membrane protein. Mitochondrion inner membrane.
Sequence:
MASGSARRAGARLTNLLYGSINSSTPATAASWTQTGLAAGELAPFGARMASNQVVRNRMKSVKSIQKITKAMKMVAASKLRGIQGKTEDSRGLWQPFTALLGDAPGVDVKKKVILTLSSDKGLCGGINSTSVKFSKALMRLTAASGPDKEASYIVIGEKGKAQLQRDSRKNIKMFITETQKLPINFSLASTLTDEILRTVQFDAIHLVFNKFQTVVSYLPTVATILSPETMANGVETGKMSDLSNYEIEGSETQAEVLQNLSEFQFASVLYNAMLENACSEMGARMSAMDNSAKNASDMLDRLTLSYNRSRQAQITTELIEIISGAAALEAS
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MTTKTRFAPSPTGFLHVGGARTALYSWLQARANNGEFVLRIEDTDIERSTQAACDAILEGMNWLGLTWDEGPYYQTKRFDRYNEIIAQMLEQGTAYKCYCSRERIDALREAQAANGEAQKYDGCCRNLPARDTDEPFVVRFKNPIGGSVVFDDHVRGRIEFSNDALDDLIIARTDGVHTYNFCVVVDDWDMGITCVVRGEDHINNTPRQINILKALGAPIPEYAHVSMILGDDGAKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEVFSLEEMKQYFKLDDINKAPSAFNTEKLVWLNQHYIKTLDPEYVASHLQWHMDDQKIDTSNGPALSAVVTALAERAKTLKELAASSRYFYEDFAEFDAEQAKKHLRGVALEPLQLVQQKLAALPEWTVEAIHQAIEATAAELEVGMGKVGMPLRVAVTGAGQSPGLDITLFLIGRARSEQRISKAIEFVADRINS
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MVSADTARTVVGILGNIIALCLFLSPVPTFIQICKKGTVERFSPIPYLATLLNCMLWTLYGLPIVHPHSTLVVTINGAGLLIELTYVLLFLIYSAKKQRLKVFLYLLLEITFVGVVAVMVLSLAHSHEKRTLIVGSLCMFFGTMMYVAPLSVMIPNGLGTLFGVAQLALYACFYKSTQRQLAERQAKASEVHLGEVVIASKSVAPSNMNGNSIEIEETPNSFQTSNHVQER
The following text describes a protein:
Function:
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Sequence:
MAFSGVKYSQIPTEEEHKIDFSSPFTYGFNKGNPAEGFTYNRGTRRHEDESTAPPSCFARCIHVLVTCLCYLLLVLTCPFSACLAIKVVKNYERLLVFRLGRQQPLKGPGMVFILPCIDRCRRIDMRQRAFNVPPQTAYTEDGGAISVGADVYYRIYDAVLAETMVKDLIGSLRVVALTTVHNVLLKKGLYDIETDRNSLNTALQRELNKSAEIWGVEISRLELSQITILRPPANGPVLLPPSNNGPAQGGPAMSPQVQTVFQMAQHFLQQASGGSKGGKTEQDRSMVAVSIPESSGTMSADFGLSPRELLSAVKLLLDESIVEQVGAIYQFELEGEDGGTFYLDLKNGGGDAGVGPPPNEEADVVMTMSVTDMQQLFSGELRPFQAYSSGRLHVEGSLRVATRLEDVVSRLKTS
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
Sequence:
MPHRIRILPEILTNKIAAGEVVERPASVVKELVENALDAGCGEIIVEIEGGGRRLIRITDDGCGMSREDALMALERHATSKIATDDDLFSLATLGFRGEALPSVASVSRFTLATRERGSIEGTEIYAEGGKIREVKACGMAEGTVVSVRNLFFNTPARLKFMKSVETEGGHVADLVTRLALSRPEVRFTCVSDGKTLFRALDGTLLDRVAALLGKTVASALHPVDLATEGVRVTGLVARPDVSRSAASHLYTYINGRFIRDRVVQHAILQAYRNFLERGRYPVVVLFIEVSPGEVDVNVHPTKHEVRFRQQGIVHDVIQGAVEETLRLTPWIRRSESPVAAPLAVPRPQQYVQGTGARQVEEVRELLENYRPAVAPHRPLFAPQPAPQPDREPPLPDSGSRMLDDTAVRRHGGYFSSLAVIGQYNASYILCQDGSDLVIIDQHAAHERVAFERLKTQFAAGRVEGQGLLFPETVELSHRESAVVREHGGELGRLGFDLEDFGGTTWIVKGIPRLLAGTDYLRLLRDTLEELQSLGASRSIADAVEDILTRVACHSVVRGEHPLTTGEIEALFAHMDATDFSTNCPHGRPVLQRLTLGEVEKMFKRV
The following text describes a protein:
Function:
Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size. Mediates resistance to enteropathogenic E.coli. Mediates susceptibility to B.thuringiensis pore-forming toxins. Not involved in P.aeruginosa susceptibility.
Sequence:
MSDGSMDDDGRLFPDLGSSTHDNREIRVRFLNRCAYPVDVFWLNPSKQPTKYGTLAQKKYLDIKTFKDHPWVARRSFDGCKVLVNEKEVFWPEPAPRMNLIVRNHCVITMKVQSLREIAGRSFLRHNPTEVPNKIKGLPRELQFEVKHFLDRKQEYSEIVCRSIPPPGPQRPQQ
The following text describes a protein:
Function:
Required for ciliogenesis.
Subcellular Localization:
Cell projection, cilium. Vacuole membrane; Multi-pass membrane protein.
Sequence:
IMLVSRYRAIIYSQFVLLLIDLFINAFGSLLSDRDVILLVIYIVQLLCLVFNLIVIFLVFFNTYVFQAGLMNLLVRKFRMAICINVIYALISVGIHVWTLIKVWGQGSSTYIWEPGYQALYVVHRVASVFYYYFYKRMALKLGDPRYYKDSEWLRKEYARSH