lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.
Subcellular Localization:
Nucleus.
Sequence:
MNSRLQEIRARQTLRRKLLAQQLGAESADSIGAVLNSKDEQREIAETRETSRASYDTSAAVSKRKLPEEGKADEEVVQECKDSVEPQKEEENLPYREEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADLENFDLRELKSEFDVILLEPPLEEYFRETGIAANEKWWTWEDIMKLDIEGIAGSRAFVFLWCGSGEGLDFGRMCLRKWGFRRSEDICWIKTNKDNPGKTKTLDPKAIFQRTKEHCLMGIKGTVHRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPDQSWEERLANSGGLREKEFLVGLLLGLLLPTATLIQRLMLLTLTLQIHLLLDAQRRSKDSVPKLHLLSQIVALGHREEEDEVEHLQVAERGAGKGTEAVLGETEGISEDVEDHIGVSLLPVDFKCF
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLSRRTITRKLNKGVSKSLLSFARYNHSITSTTTPASSQPHIELTTFANGLRLITDSTPGHFSAVGAYIDAGSRYEDPKAPGLSYLRDRLSWKSTEDFTGQQMLENLSKLGGNYMSSAQRESMIYQASVFNKDIDRMVGMIGQTIRYPIFSDQEFQEALQTAEYEVAELAYKSDLYLPEELHTVAYKENTLGLPLFIPQERIPLVSKSDVIDYNNKFFQPQNTVIAMVGVPHEYALKLIMENFGDWANTTTTKPNPGIKNYTGGEISLPYTPPLYANLPELYHIQIGFETTGLLNDDLYALATLQKLLGGGSSFSAGGPGKGMFSRLYTKVLNKYPFVENCMSFNHSYIDSGIFGITLSLVPEAAHVSSQIIAHELSQLLVTEESQGGMNAKEVQRAKNQLISSLLMNVESKLARLEDLGRQIQCQGKITTIDEMVDKINRLTIKDLQNVAEKVLTGKVITSNGGTSLGLPSIVMQGERETFGDVEFILRRYGLGNYKGPEITEPRDFSSNQNEKKKKSRWF
The following text describes a protein:
Function:
Putative transcription factor involved in the generation of biological rhythms. Activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (5'-CACGTG-3') present in their promoters.
Subcellular Localization:
Nucleus.
Sequence:
MEVQEFCENMEEIEDENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSVFL
The following text describes a protein:
Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Sequence:
MDGDDEKTQMLKKAFAMFDQGKTGFIETNRVAAILNTMGQQFDANELAVTIEETDKDKTGKLTFEAFYSIAANFLEDEDDEAMQNELKEAFRLYDKEGNGYITTAVLREILGALDDKLTSDDLDGIIEEIDEDGSGTIDFDEFMEMMTG
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MTTSPTSDVFSDEVDSISIRDKALLKRSVSKHHNNNFKAGYVPVHEQHLTKTGLRGRKTFAFWTLVALLFILAVGNLLLTVTILGVLRLGQGMESIELVPDEYAVKFFGVTDLGHMYKRDGKIEGFKDEPVAITSEESAVLLNIMSLRNGRPSNQMRVTKNGTSFWGFDSFHVRNKQGAVLFSTDSPNFHALRGANDFDAKIVFTNRIASPVHSKLKVEGRVLTFKGSEGTRMDGKDIFWSADQDIYLKTNNGSIVLSGSDGTLIDVRRIPIATVKNNNYVTSQYKVCVCMPEGKLFRIPVPSGPNPRVFCHHINTQPPHNPCM
The following text describes a protein:
Function:
Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQAMASYTCISCRVAFADPDIQRAHYKTDWHRYNLKRKVADMLPVTAENFQERVLAQRAVVEEQSKETATYCSTCSKRFASFNTYENHLKSKKHLDLEKKATESITKKVELMNEKNLEKGLHPDSVDKDVMNTAIQQAIKAQPSVSPRKQPNETTATASGKQDNEGASARPEKPPRQQWYEEQAKRLALEETEHDLVEEEEENWDDMDSAEEGEVDSDNAMEHMNGAEGEDITADESASGAIPVTDCLFCTHHSCSLIKNIAHMTRVHSFFIPDIEYLQDLYGLFRYLGDKVGVGKICLWCNEKGKSFYSIESVKAHMNDKSHCKLFTDGDAALEFADFYDFRSSYPDHKEGEDIEMTEKEGSDKTLEYNDDTMEMILPSGSRIGHRSLMRYYKQKFGVSRQVVVSKNQKAVGRLLQQYKALGWTGGTGSVIQRGRDMQYVQRMKSKWMLKTGMSNNATKQMHYRPQVRF
The following text describes a protein:
Function:
Protein kinase that regulates cellular motility via phosphorylation of membrane proteins.
Sequence:
MTPDSRHRRLLANRYQLVELVGSGAMGQVYRAEDKLLGGVTVAVKFLSQALLNPRMKERFEREATISALLGEKSIHIVRVRDYGLDEKEIPFYVMEYLQGENISDVIKYRPLKVERFLKIARQICFGLDCAHKGIIYQGEACPVVHRDIKPSNVLLVEDPALGELVKILDFGIAKLVQAAEESKTQAFMGTLAYCSPEQMEGKELDSRSDIYSLGVMMYEMLTGEMPLFPDNSSFGGWYEAHHHTKPHPFSARYKIPASLEALVMNCLAKSPKGRPQSVDVIIRAIDAIEAEIKAPPISDTEKTQIAPHLLNTDMEATVVAQRGPGIVPETRLPLVSELCKQLEWPSDKPKQKIVFPYVLNAAEGKLASLWVMLNQEDILTRMSSIRYNQFLLMTSPHPMVLWITVLYHREYGPRWLPCYLDLKTRSGQSFAQMLGESGTYWLLFFALENPTRCQHMLTATVAPNQCKLLKEWAQTSQSMPGGKPQVTKRLLKQELDRLKPKIEAKLSQVKPSFNKEVSGL
The following text describes a protein:
Function:
Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase gpi14 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MRQRITYIQKPSLPFHPSQTTLTRDSLYVESLDAAREERVTFSFDELPSELWQVLRQCHQLHIRWASERAFEAVSPLSSRISPGLHVFYSPVEAGRAKRDSEGREPLCTLLKKVFDDELRCESPEKSFITPPILSKRFASTTAYQFYELLPSLGNLVTYIQQKFCGTDDKCHQRAASILSADSVDINYDSISHALTMSGFWSQAPGEQGWTETIGKHEGGTDKVEIGLLGAEPASEPEEIKVGGLLAVVGQDEELKPTLFSFPSRHHPLHEDATYSVTFPPPTGLHPTMTISIAPEALKEPPRRPDATCALHAYLTLPSKLFGDKYQLSTTDPLFLKSHNLASLRAVAGETDLEAPDWSISRWGSNWLLELASPSESDEVAEEWNITIPLHLRYLPPSESGYQPASVPWPVVFWACSAEDGTKMGVNPFDRINLGWEGLFGPRTMFYQLHPSPSPEGGNLVEELEVPVLTLKENSGIFNSQVIELGTFAVISIGFLWVLWKLGLVARSSGIRPQHQRNPGKRDKAE
The following text describes a protein:
Function:
Plays a key role in chromosome recombination during meiosis.
Sequence:
MHEPMKTLKNIHAEIRICQKFPKSTVQKRFSEFEELIKAASKNARNWKPISSVELFQGDSSLNELFEKLVIGTCELRDGELFENVNDLTINPSNIHVYKLHKDGPLSQNIGDDDGDESIIGSQLWQLPCVEFDSIWENLIYDSNLKNEVMSYVAALARLSEKHVNTKIINVNRLILLTGPPGTGKTSLCKGLAQHLSIRMNDKYSKSVMLEINSHSLFSKWFSESGKLVQKMFDQIDELAEDEKCMVFVLIDEVESLGMCRESSSSRSEPSDAIRAVNALLTQIDRIRRRDNVLILCTSNLESTLDKALVDRADIVKNVGQPSDFARYSMLKSSIMELARIGVVIDNEVHTDYWPQDICDTKAPRNEFTEILFKIAQEARGLSGRAISMLPTLVYSKSPEETITLPNCMNLFLEAVKERLSRNN
The following text describes a protein:
Function:
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
Sequence:
MKRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRHRAEIDVARELALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPEADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVSLGMAKDIRFETPLMWIDKAETWALADYYGKLDLVRNETLTCYNGFKGDGCGHCAACNLRANGLNHYLADKPTVMAAMKQKTGLR
The following text describes a protein:
Function:
Channel-forming protein essential for import of protein precursors into mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MGNVLAASSGAPGSGASNLGLGLQEPAPLPSNSGSLTESSSSAEGLDSLAAAKDAALENPGTVEELHKKCKDIQAITFEGAKIMLNKGLSNHFQVSHTINMSNVVPSGYRFGATYVGTKEFSPTEAFPVLLGDIDPAGNLNANVIHQFSARLRCKFASQIQESKVVASQLTTDYRGSDYTLSLTVANPSIFTNSGVVVGQYLQSVTPALALGSELAYQFGPNVPGRQIAIMSVVGRYTAGSSVWSGTLGQSGLHVCYYQKASDQLQIGAEVETSLRMQESVATLAYQIDLPKANLVFRGGIDSNWQIFGVLEKRLAPLPFTLALSGRMNHVKNNFRLGCGLMIG
The following text describes a protein:
Function:
Global regulator of carbohydrate metabolism. Represses the expression of several genes involved in sugar transport and utilization, in particular phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) genes. Represses expression of ptsG (EIICB(Glc)), which encodes the PTS system glucose-specific EIICB component. Also represses the expression of the manXYZ operon, encoding the mannose-specific PTS system, expression of malT, encoding the transcriptional activator of the maltose regulon, and expression of the pts operon, composed of the genes ptsH, ptsI and crr. Represses its own expression. Acts by binding to the regulatory region of the target genes.
Subcellular Localization:
Cytoplasm. Note=Interaction with dephosphorylated PtsG leads to the sequestration of Mlc in the inner membrane fraction.
Domain:
Is composed of three domains: a helix-turn-helix (HTH) DNA-binding domain, a PtsG-binding domain and an oligomerization domain. The zinc ion probably plays an important structural role for the correct orientation of the HTH domain.
Sequence:
MVAENQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLVQELEIKEAGNRGRPAVGLVVETEAWHYLSLRISRGEIFLALRDLSSKLVVEESQELALKDDLPLLDRIISHIDQFFIRHQKKLERLTSIAITLPGIIDTENGIVHRMPFYEDVKEMPLGEALEQHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSILELAQLRLNQSMSSMLHGQPLTVDSLCQAALRGDLLAKDIITGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPVISDSIRQQALPAYSQHISVESTQFSNQGTMAGAALVKDAMYNGSLLIRLLQG
The following text describes a protein:
Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.
Subcellular Localization:
Nucleus.
Sequence:
MNPLCGQIRALRDENLEEHEERVKSLLYTGTNMLDGNAGLLSNYEVLAILKEKKKAIAEQTQYVPENLATVTYENEQIMKDFMLAISKFKLTKAEKLMLLNQRPTSLVELHLIIEETEERFSEEESNELLQIIDDILPPVHPHDNEDTEDKGQTNEEQN
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MFMILAVAALLVLQAAAQPTEDPKCQYAWASIGTSRGDLHIHDGKPGQGAVAWGSFQNDIHISGWTFLEVQSNGSYADDAQAYAAGAVEAYLTQDLMEKQFNNMYNRYCEGQPQYCERLYVFLLQNLRYSNIQENLHESTDPYWHMVHLQMKQLAGLSDQFENKTLIVSNEYLDITRALFLNIEGDLLDLEKFLKRVPDEYSMDQTPACSALIKVVADNDILFAHNTWFGYRKMLRIEKKYTFPWQLTSKSSDTIPGHTISMSSYPGKLVSLDDFYLASTGLAITETTIENSNDSLWNLVRPDSAPLTWVRGMVATRLAVTGPQWVDYFGKLNSGTYNNQWMVLDYKLFAPGSAIGKNTLWILEQMPNITKAEDVSAYLQNQKYWGSYNVAFFPAIFNISGQPDMVKKYGNYYSYDKSPRAQIFRREQSKVEDVDTMLRLMRYNNYTHDPASRCNCTPPYNPVYAIAARYDLLDPKGSYDVPYMFRRAGAAIDMKLTNYAMFKSLEFIAINGPPFHPNSSVLPPFQWSTSGFQDLHEGHPDKWMFGPTYHRWNSSPNL
The following text describes a protein:
Function:
Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.
Sequence:
MPTNPSTAASTASTSAKTALVATAKSSPLDVLFQDDPYLEHQRSALEHRHSLFQAALTKIDQTEGGIAQFSSGTNRFGFNVSSTAITYREWAPGVKAAFLTGEFNQWNRDSHPMKVDSYGVWEIVLPHKKDGSPSIQHNTKVKLSMIKHDGQRIERIPAWIHRATQDLSVSPVYESVFWNPPQKYQFRHPRPARPTSLRIYEAHVGIASPHGRVATYKEFTRDVLPRIANVGYNTIQLMAIMEHPYYASFGYQVTNFFAPTSRCGSPEDLMELIDTAHSLGIIVLLDVVHSHASDNILDGINQFDGTDHHYFHEGSRGRHELWGSRLFNYGHHEVLRFLLSNLRYWMDNYKFDGFRFDGVTSMLYLHHGIGTGFSGNYHEYFGDSVDMEAVLYLMLANHLVHSLNPAAITIAEDVSGMPTLCRPVSEGGVGFDYRLSMAIPDMWIKTLKEKTDDQWEMGNIVFTLTNRRWKEPAIAYAESHDQALVGDKTLAFWLMDKEMYDFMSDLSPMTPIIDRGLALHKLIRMITYALGGEGYLTFMGNEFGHPEWLDFPREGNGSSFHYARRQYNLVDDPLLRFRYLNNWERAMHQLESQYDWLSSGQFVSLKNEGDKVIVFERGNLLWIFNFHPTQSFADYRVGTIWNTTHSVALHSDRPEFGGHSRIAEDCQYIPTKETWNGRPNWIQVYIPSRTVLILKHE
The following text describes a protein:
Function:
Part of the ABC transporter complex MolBCA involved in molybdate import. Responsible for the translocation of the substrate across the membrane. Functions as a low-affinity molybdate transporter.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The transition from the outward-facing to the inward-facing conformation is realized through the asymmetric motion of individual subunits of the transporter. Nucleotide binding is coupled to a conformational shift at the periplasmic gate. This shift is akin to unlocking a swinging door: allowing just enough space for molybdate to slip into the cell. The lower cytoplasmic gate, identified as gate I, remains open throughout the MolBC-A mechanism, and cytoplasmic gate II closes in the presence of nucleotide.
Sequence:
MQPDSYPKILFGLTLLLVITAVISLGIGRYSLSVPQIGQILWAKATALEIDPVQQQVIFQVRLPRILTALCVGAGLALSGVVLQGIFRNPLVNPHIIGVTSGSAFGGTLAIFFGFSLYGLFTSTILFGFGTLALVFLFSFKFNQRSLLMLILIGMILSGLFSALVSLLQYISDTEEKLPSIVFWLMGSFATSNWEKLLFFFVPFLLCSSILLSLSWRLNLLSLDEKEAKALGVKMAPLRWLVIFLSGSLVACQVAISGSIGWVGLIIPHLSRMLVGANHQSLLPCTMLVGATYMLLVDNVARSLSDAEIPISILTALIGAPLFGVLVYKLKRGGMNE
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLFRGVLRHLASCGIVMTRTSKRAVQDIGSPCIQQCRSFLSFTGPLTNKRKEYSERRIMGYSMQEMYEVVSNVEEYKLFVPWCKKSTVISKRTGYAKAQLEVGFPPILERYTSILTLVRPHLVKAVCTDGRLFNHLESIWRFSPGIPGYPRTCTVDFSISFEFRSLLHSQLATVFFDEVVKQMVAAFERRAGKIYGPETPIPRELMYHEIHQT
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSQYAVELCEILVEEFFGDCCSAVASALLRHGRLTIPMLQKRTSLPGPKIRQALVSLMQHHMVLYVTVIENVREVTYYETQWKEIYNILRKGKDVYLISQKLNQEAASVVKYLSTQGRARVLEVFNAFDKKVDGSDEESRMMQKNLTELIYQKFLLVVQPRHLIPVGDQEMQLRIKHLDRRKSENVSEIKKNREVDDSVALEMLELRAADMSELQGLTRKPKESIPHPTKRRKRAVGSAPSVSTDLNNILDDDNSILVPDLSAHVRINSGKLSVLSKNARLTHWVERRIGKSTSLVYSHVLSMLEPRLFSISNQSPVFTLTTMELTRNFPNDIDVESSIVDKQYSVNSASNELRVMEKLNELDELAEEDNYEESVDENANRKSKVLAQHLELLADCSLKFISKIGNRGMGEWAVNFTHLTDMLRAIEYENFIEQKFGERAIRLLRIIKDKGKIEEKQLANIALLRQRDLRTVLQAMAEIGALELQEVPRSSDRAPSKTFFLWFHRPDRAYSLLLDELYHVIARLYMRLRDARAQRAQLIEKAERIDIKGNEEQYLQKFEQAELKKLYSYEEKLLLQASRLDDMVLVFRDNL
The following text describes a protein:
Function:
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Also participates in cell permeability to H2O2 and H2O2-mediated signaling. In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MPGGRGGGGQDGGGRGPGGRVLGGRGPGAGGAQLLYKRSCLGPASPVPVPAWCPSAARSRPGGALDGAPRPRPLPQPGPRPLSFPLPPSLPSPSLLPPDGSRPQGSPASGAMGRQKELVSRCGEMLRIRYKLLRQALAECLGTLILVMFGCGSVAQVILSRGTHGDFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFALCFLAREPWIKLPIYALAQTLGAFLGAGIIFGLYYDAIWAFADNQLIVSGPNGTAGIFATYPSGHLDTLNGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGFVVLVIGTSMGFNSGYAVNPARDFGPRLFTAIAGWGSEVFTTGKHWWWVPIVSPLLGSIAGVFVYQLMIGCHMEAPPPSTEQENVKLANVKHKERI
The following text describes a protein:
Function:
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTVLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDVQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFRRSPGDTVASKASAEGGSRGMGTHSSLVQ
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSVLLETSLGDIVIDLHTELAPRSCTNFLKLCSKHYYKLNAFFRVEKDFLAQTGDPSNTGKGGASIWSQLPSTSQDSSTSTYFTPESSDGQLKHLKKGTVSFACFRKHVQGADEDGEGGSCELLAGSQFFVTLKDELDYLDGRHAPFGMVVEGHEPGGTLDKINHAFTDDQKRPLRDIRIRHVVVLEDPFADPDGFCAPSRSPSPTPCQVRALRLADDEDVHSDVDPASKEEMRRNADTNAAALTLEMVGDLPFAEIRPPENILFVCKLNPVTRSDDLELIFSRFGKILSCEVIKDKKTGDSLQYAFIEFDKKDDAERAYFKMQNVLVDDRRIWVDFSQSVSRLHGDWVKKRNAGSDAPRAHYQSGADEQSVDSYRPNAGGYQKRGDDRRHDRRDQPTARGDTSSWHSRQDSERSYRESNDDTRDRSNKRSRRHHDDVPQQSRSRSERHDSHRDHERHHLSRHVRPSDEGESKCRYEAHSHTRHDEHTRRHDSSSTAARRDEDRRSERSRHDRDRDRDRDRDRDREREHRRRTEDRRRHDDRQRSRDGSRR
The following text describes a protein:
Function:
Heavy-metal-binding protein. Involved in the maintenance of heavy metal homeostasis and/or in detoxification.
Subcellular Localization:
Cell membrane.
Sequence:
MGEKKEETATKPQGEKKPTDGGITTVVMKLDMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGNVDPVEVRDKVADKIKRPVELVSTVAPPKKETPPSSGGAEKKPSPAAEEKPAEKKPAAVEKPGEKKEEKKKEEGEKKASPPPPPKESTVVLKTKLHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGIIDVKQLTPYLNEKLKRTVEVVPAKKDDGAPVAAAAAAPAGGEKKDKVAGEKKEIKDVGEKKVDGGGEKKKEVAVGGGGGGGGGGGDGGAMDVKKSEYNGYGYPPQPMYYYPEGQVYGQQHYMMQGQSSQSYVQEPYSNQGYVQESYMNQGYGQGYGQEAPPPPYMNQQGYADPYGHMRAPELFSDENPNGCSVM
The following text describes a protein:
Function:
Acts as an alpha-ketoglutarate-dependent dioxygenase active on sulfonates.
Sequence:
MATLTETISKADKHDEKLTDFQYSKKIFNGVHEVEDDKQRTDFTTVRFGDVEKKFAVPKDYKYKNVLPTFPNAVYNLTGELAFEDKGLLADPKFSNLLKDVTKVEHLARDLGTVLYGIQLSKLNDAQKNELARYIAERGVVYFPDQEQTLEEFQELGQYYGHSHKHGSNSRPFEDKFAEFQVVYSDRFSPYDQHAKNNSLRYWHSDVSFEKQPSAQTFFKALTVPEQGGDTLFISGYAAYEALSTPLKKYLEGLTVVHSGKEQSEYHRRSGQHVRLDGDTNAHPIVRTHPVTGWKSLFISPGFTRYIPGIPRGESDAILDYLYQHIANLSQSTVRIKWTSNGVAAWDNRIVIHRATYDHLPQTRHLVRIAAQGEVPFFDANSHERSEDLRE
The following text describes a protein:
Function:
Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.
Subcellular Localization:
Cytoplasm.
Sequence:
MALSGGTDRGSHRMDKSIILPPDEIFRNLENAKRFAIDIGGSLTKLAYYSTVQHKVAKVRSFDHSAKVSFQETDGDPLYEISVQEEITARLHFIKFENAYIETCLDFIKDHLVNTETKVIKATGGGAYKFKDLIEKKLKLKVDKEDEMTCLIKGCNFVLKNIPHEAFVYAKHADSEFRFQNTHPDIFPYLLINIGSGVSIVKVESEDKFERIGGSSIGGGTFWGLGALLTKTKRFDELLQLASKGQHTNVDMLVKDIYGGAYGSLGLTGDLIASSFGKSATTDKEFSKEDMAKSLLHMISNDIGQLACLYAKLHNLTRVYFGGFFIRGHPVTMHTITYSINFFTKGEVQALFLRHEGYLGAIGAFLKGAEEDNPNQYSWGENYAGSSGLMSVSPELNPVQRARSGTFPFDMLEMDRLERQLVNLPLLHDPTSYIPDTVDLTEDALARDYWLYCFEDALDGVVKRAVASQKDQPEAAERAEKFRQKYRHKLQTLRHQPFAYGSLTVRSLLDTREHCLNEFNFPDPYSKIKQKENDMALKYYLKVVKSVEELSWEQRQFALVKGLLAGNVFDWGAKAVSDVLETDPEFGFEQAKQQLQERPWLVDAYSQWIERMKGPPHKCALFFVDNSGIDIILGVFPFIRELLLRGTEVVLASNSGPALNDVTNSELQILTERIAAMDPVIQSAFKEDRLALVQNGSSSPCLDLSRLDKVLATVVRERGTDLVIIEGMGRAIHTNYYAMLSCESLKLAVIKNSWLAERLGGKIFSVVFKYEVPSKSQEQH
The following text describes a protein:
Function:
Promotes leaf senescence.
Subcellular Localization:
Cytoplasm.
Sequence:
MATTASSAANSASRFSIDSSISRSRHGDSSPWLLPSDSHDHPTLSLSQDDPFSAPSVSPPTGNNSSDYDNADKKPPPVWNMPSSNSSSDVGPVMGAAESWPALSLSARSSSIKSPSLDASKPFPDGSSSSIPPPQATSNTSTNANAGSSVSATSSENSAVNNSQRKPFRRNNNTSSSSTSSNVSNAAPLNTRDQNHSQRGGGSFGSGNFRNSQRNRNSSSYPRGEGLHHGNRRNYEHGNQSGFSHRNYSGRDMHLQPQRGVGMIRPQMLMGPPSFPASSAQYMAAPQLGSYGGPIIYPDYAQHVFMPHPSPDPMGLVGPFPLQPMYFRNFDAILYNKILTQVEYYFSADNLSRDEHLRDQMNDEGWVPVRVIAAFRRLAELTNNIQTILEALRSSEVVEIQGETLRRRGDWDKYLLPREPSRSGPAAGASNNASLVSQIESMTLSERSREGV
The following text describes a protein:
Function:
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Sequence:
MPQSRYEKIISARWIITVETDGEVLENHAIAIRDGKIAAIIPAADAAGLEADERLELPDHVLMPGLINLHGHSAMSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMIRGGTTTINDMYFYNAAVARAGLASGMRTFVGCSILEFPTNYASNADDYIAKGMAERSQFLGEDLLTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLIHCHIHETADEVNNSVKEHGQRPLARLQRLGLLSPRLVAAHMVHLNDAEVELAARHGLSTAHNPASNMKLASGISPVSKLMDAGVAVGIGTDGAASNNKLDMLAETRLAALLAKVGTLDPTSVPAAAAIRMATLNGARALGIADKVGSVKVGKQADLIALDLAQLETAPAFDPISHVVYAAGREQVSHVWVKGRALMRERKLTTLDESDLKARAGDWRNRILAK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAAYCGTMSSEGRGPEPPQEDGDPGDPVRPRPRAGRGLRRARRAGAGTSCRCVRCGRRFPGRAALRVHARRRHGRRRPVLGCPECGRRFSHAPFLALHRRAHVEGGQLTCQRCGRDFPHWAALALHERSHAGPQLFACTDCERCFAHRRQLVAHQRCHPPTPRRFICGGCGQSFAWWAELVAHKRVHAPGPRPRGRPALGAAPGPPGAEDRPFQCARCEKRFRHKPNLIAHQRVHTGERPHQCPDCGKRFGNKPYLTSHRRIHTGEKPYACPECQRRFRHKPNLLSHRKIHQRDRPFPCPACGKRFSHRTHLLAHQRAHPGPDGPFPGPPCPESFGRQRSPRARQRPHAAQQGARRSAQDADAAARPRARPAERPFPCPDCGRRFAQKSRLAAHRQEHTEERPFQCPDCGKAFRHKPYLVAHRRIHTGERPFRCPDCGKGFSQKSNLVSHRRVHTGEKPYPCPDCGRRFSQKSNLITHRKSHSGERPYSCAHCGERFGYKQKYLAHQKKHAP
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
Subcellular Localization:
Nucleus.
Domain:
The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain.
Sequence:
MMGGECKVHQLQAAGDGGPGAVAPFVAKTFHMVSDPSTNAVVRWGGAGNTFLVLDPAAFSDFLLPSYFKHRNFASFVRQLNTYGFRKVDPDRWEFAHESFLRGQAQLLPRIVRKKKKGGAAPGCRELCEEGEEVRGTIEAVQRLREEQRGMEEELQAMDQRLRAAESRPGQMMAFLAKLADEPGVVLRAMLAKKEELAAAGNNGSDPCKRRRIGADTGRGGVATGGDAAEMAQSRGTVPFPFSVLGQVFY
The following text describes a protein:
Function:
Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Mitochondrion membrane; Peripheral membrane protein. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
Sequence:
MAAAKSENLSVVVHGPGDLRLENYLIPEPGPNEVLLKMHSVGICGSDVHYWEHGRIGHFVVKKPMVLGHEASATVVKVGSLVQHLKPGDRVAIEPGAPRETDEFCKIGRYNLSPSIFFCATPPDDGNLCRFYKHNASFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGNKVFVCGAGPIGLVTLLVAKAMGAAQVVVTDLSASRLSKAKELGADFILHISKESPQEIASKVEDLLGCKPEVTIECTGAEAAIQAGIYATRSGGTLVLVGLGSEMTTVPLVHAATREVDIKGVFRYCNTWPMAISMLASKSVNVKPLVTHRFPLEKALEAFETSKKGLGLKVMLKCDPDDQNP