lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MLALLRKMEDHPGHPISNYDFLSGNGCHTKKLGHKIYDQDSSSTKSGRSQQEASAMSDSNLNEQHTSRSSAQSDNDDGHGKYNQVMMKSPLSLGNPEAGSSPAKVDYSQSFACMPYTADAYYGGVLTGYASHAIVPVSAESTAEEPVFVNAKQYHAILRRRQIRAKLEAQNKLVKGRKPYLHESRHRHAMKRARGSGGRFLNTKQLQEQKQIQASTGGKNTFLQSSPTFAPSASAPSDMSNVSTSSRMLANHQERACFPSAGFHPMASLGARSGGDAELAVNGMQQRASMMS
The following text describes a protein:
Function:
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.
Sequence:
MSRMLSRDPLDIENILTLNPRTPTHASLYSTAAKKQAKKHWKRNPDRSCSKCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEIFKTMNIPQIRNPSLPATEAMPAQYKTKIALIGAGPASISCASFLARLGYSDITVFEKQKYLGGLSTSEIPQFRLPYDVVSFEIELMKDLGVKVIEGKGLGMNGMNIRSLKEEGFKAIFIGIGLPQPKIDDVFTGLTTEHGFYTSKDFLPLVAKASKQGMCACRSPLPSIKGPVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNMRAVPEEVELAKEEKCEFLPFLSPRKVILKGGKISGMEFVRTEQDDDGNWIEDEDQKIQLKAEVVISAFGSVLTDPAVLEAMKPIKFNRWGLPEADPVTMQTSEAGVFVGGDIAGLANTTVESVNDGKQASWHIHKHIQSLHGVSITNKPELPLFYTPIDLVDISVEMVGIKFPNPFGLASAPPTTSAPMIRRAFEAGWGFALTKTFSLEKDIVTNVSPRIIRGTTSGSIYGPGQGSFLNIELISEKTAAYWCQSITELKADFPKNILIASIMCSYNKDDWTELALMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVTDVVKIAMAAQEGGADGVTATNTVSGLMGLKADATPWPAVGRGSRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSIDELQDWDGQSPPTIRHQKGKPVPTIAEIKGEKLPSFGPYLEKRKRILAENKINDLTCNTSPVTKEKTHFVPNKPIPSVKDVIGRALQYIGSYSQLNIQEQVVALIDEEMCINCGKCYMTCNDSGYQAIEFDPETHLTTVTDSCTGCTLCLSVCPIIDCIKMVARTTPYVPKRGLPLTVNPVC
The following text describes a protein:
Function:
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Sequence:
MSRLAVFASGSGSNFQSLVNAVEEKRLDAEISLLVCDKPEARAVGRANYHHIPCFAFSAKAYESKEAFEKEILKKLEEYEIDYVILAGYMRLIGPTLLEAYGGKIINIHPSLLPSFPGKDAVGQALEAGVKVTGVTIHYVDAGMDTGPIIAQEAVVVSEGDTRESLQKKIQQVEHKLYVNTVNQIVQSVKESTVN
The following text describes a protein:
Function:
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Subcellular Localization:
Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Membrane; Lipid-anchor. Nucleus.
Sequence:
MPVLCETDEVIPGEMPGPHWQDSVVFPVSSDQIEQLHRRFKQLSGDQPTIRLCSSRLCSVRSVSVPPTSQLPLSVKLQWRPVCSKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGSSGLADEINFEDFLTIMSYFRPIDTTLGEEQVELSRKEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCVGQMEPDQVYEGITFEDFLKIWQGIDIETKMHIRFLNMETIALCH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MIMDNSKTTSKTTLLKLMLLRAWKERWTDCQWGINVKTILTRGVSGDVYNLADAIIQQAVVGSGANMLFLSYLKHSLCAHLISHAAVLNRIAKYDQYDKHHCLIALLDFLKSIIDGVTCRGKQEEAILTKATVSLVHWLLQIYECVLQSYAEDSTLQPEEEEVVQRVAVVLERIVENPFLLGVLSIGKCDDPELFIALQKRFNGISNLTLTTGYVANVGAGNANSLTVTDCMRKLVLLEVDALEMRPFDGGKVEPITYSLQPLIAIEVLLNPMCDTHQYVAQLINLKRLKGFTYARLYCELMRGCLIALNNVEGTAKESLLCAFAFIKVPHILHQLHAKTNGAEQQDEATGATYSVEVLEAFELLLQDTPVLDYMDMKCACNVVECLLKEMVKLQLLTDTHVKQLVALREPVTAGLHKLDANSAPLTMMLKFVFRVESPLAGILKALSTDCSKVQDALLAMLCQVLTGNSLDLVLSVASVEGKFKAFISGLLKCNDYAKQATTAEIGKAPTTRSALFDVSFMILASIAQSYGSDVILAEGGNSFFEKWVRDYMVERKKTKSPMTMVKQADPMVLEELIMAMNNSEGMYVGLKASSLRWEDICYTIPALVHQVLMAWESESIAPLEIKKMLDGLKAYFSTFAVCAASWLCAYMQMVRQDEQLKPMNMVQQLCSALAGPLADEWQQQDYCKERFGLMGQIVRRMQQEFLRTPQVNPKLRALFPSQQQQHVVSHLPLEEQFEEAWKAIAERGWLPIETTFLLDTLLQSCGPAWLVEKLIGKLFVCKYVRDLNKTMDIIFAIMHLDIERCTIALLSQLVPMMLLNKAQTPDIVDPQSRVLAKLCVYCIIVTMETSLTATKKRTRGTASSELEDLDALCTSAKLRKIELDGMGVGCTEAATGGASGTEFSLDSALEPTASAWTTEAASIATLKEPLQSCLQTLFRTFAQHIATDELSPKVYFVFQFLSLLVESGRERIMCVLKLLPNGLVQSLLKINATDEMTVGLILRLYDLNTPSGRQFAMSDICLLRNIQMRKESIKL
The following text describes a protein:
Function:
Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Atg2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an atg18-PtdIns3P interaction. Atg2 then extracts phospholipids from the membrane source using its NR and transfers them to atg9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MAYFLPSFFQKRLLRYALSRLELVDTEALDLDSLGIRWGQRSTVELRDIGLRLELPASSELLSAKVQFLKITVPADIYSSGIICEASGINVHLQLPSEESFSTAKDGNPNSRSPSKAGTHDSSSDHILPTPADLAESFLDAEPKEEKEELQAAITSRSQMLQRTSASISDDEEELGLGNEGVSLPSFVAAFLKGVAERLQVRVDNVSIRVDMEMKQEGVVKREPENKPDNVTGLLTVREVSVGAVSSATSSSEQEKLFRNRPIVISDINMALISEPIVFSNYSRFAPPASPTTPVQPKSSEPSSRIPSPLPGHTPDADSFLAMTRSTILETQQEHWIQDIEEPGVGRMEGSAYTYDGRFSDADTDAEDRSDGYLEGAQQFLDNDKLLDNPAYLDSVIDSQLHDDDLEPPEDLVPQDDQFPPSSATPRPPKPEVHMYRETSPSGIDTEQTAPFSHYGDGFFMDRSPHGSQPYLGPDHVATRNASHSASSPSGSLPSREISNRQTAPPSESGSIGSSDFANGGELSESKLFSTEEAQSMYMSAISHGSSRSFVPNVPGAWDLWESTVAQDMHAGTQLTDAADAKQDVQDETSISTPKLTAQAASAFTEKRSFGEQSECLSEAREPDLAPLSPTLSKLSDVAKRFLRIDRISISIPVGEDRRHTDETVHSSDLNLASDSPKDSTVHSGHSSAESEFLSSTMYASARLRSDSINLAPSFEGTLPRSLPRQGKKADHDPISKSQPGDIAVEISAVDIRFDNAVGWLVVKIGQRVLHAFRDGGNVSSGKPAPESVQTRHSLALTLHDFSIKYVDHIPGQTYALNDYDPHSSSFFGLPHEDIILRAEASGLTARYLADKSATKFSLDVSKFVFGFAWDDLISFSESLKMRESTRDVLAPVNGDISLSLTKSSDSASLTITTLPLRLHLNVQRLEEIFGRVGGLSTILELGSSISSASTGFSTAKNMQRDSPRRARGVHFESSPPPENILPANPQLSWKVNARVGGIVFDVVGETHYLRLKTTAVKVVSRFEGIGVQIDKAKLSGPLPLDDSRDAPAKINLSNIRVEFLYSPKEPDLDRLLAIITPSKDKYDEDDDIMLDTLFRQRRQGSVLRTTVADAKIIISRTSDLESLSQLEEELGKLSTVAKYLPEDDRPGILTLTLIRELECQVYLGGPVGNITTHLRNAEAAYISMPSLIAAQLGTIKVVRNGSEELVGEALPASGSQGQNQSQLPILMARYIADEMDPTIKIKSHNLRVEYTIPSIIAFLGLSEDQTTGDVAANMANSLANIAESQHLHRNASETSIGSKGRQASAKPRKLAFALRDCVLALNPRCTTAKGLVVLTNAKFSAAISDSGCSEAMLDLKKASIMVIDDVKNMGLAENLQRGRSTIPQSDQIQSFIDMGFVPVSSISSAMATVKLLQLDDDGTKSVDVELKDDLLILETCADSTQTLISIINGLQPPTPPSVAVKYRTEVLPIEDMLASFSGDAFAMDPPPGQAEITEAPTIVEPEDGGPRIEDELEYVSDFYPVKSGPDNLAPTGSAVPSESNELLDSFHSQYYVSSSVSDLEFKEDHFANHSAVGGTAHRWDSTQNTYGLTDDSKIRKSPLRIRVRDAHIIWNLFDGYDWQRTRDTISKAVKDVEKRATERRARAGSRASPGFEEEEESVIGDCLFNSIYIGIPANKDPRELRNDINRNIDDLVSETGSYATTTTVTGATARQAQSPSYRGRRLKLSRSKYHKMTFELKGICADFVVFPPGSEETQSSLDVRVNDLEIFDHVPTSTWKKFATYMHEAGERESGASMVHLEMLTVRPVPELAASELVLKATLLPLRLHVDQDALDFICRFFEFRDDTAPTPSSPADIPFLQRVEVNAVPVKLDFKPKRVDYAGLRSGRTTEFMNFFVLDGADMVMRHVIIYGVSGFDKLGQTLNDIWMPDIKRNQLPGVLAGLAPIRSLVNVGGGVKDLVVVPMREYRKDGRIVRSIQKGALAFAKTTSNELVKLGAKLAIGTQTVLQGAEEMLTAPTATTLGSEEDMIDEEEANKISPYADQPVGVVQGLRGAFRGLERDLLLARDAIVAVPGEIVESGSAKAAAKAVLKRAPTVILRPAIGVSKAVGQTLLGAGNTLDPSNRRKIEDVSVMVKYVSRVCLLTSLLRNINAIKTVGHIGQL
The following text describes a protein:
Function:
G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (By similarity). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (By similarity). Also plays an important role in inflammation by modulating neutrophil functions (By similarity). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (By similarity). To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer. Involved in production of retron derived msDNA (a branched RNA linked by a 2',5'-phosphodiester bond to a single-stranded DNA). Strain K12 / MG1655 does not have retrons, however they can be expressed in this strain which requires this enzyme (tested with retron Ec86).
Subcellular Localization:
Cytoplasm.
Sequence:
MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV
The following text describes a protein:
Function:
Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 1070 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Sequence:
MKRFLLSRRQRHLRMICFHNISLFRANGDSKLIKEYGDGFIPCFFILESIRGELLYVSEVQSGSLRKLSFQELPKLTGASTMIVLKLVGLVPSDILCTISSDKNGIIDDKWCVLCTYTIDLNKLQPINEDTVLITGTNAPVLDLIDGSYTLAAEKIKPLKGLVSSHKRNISQVKIKFSLAYSSLLKLNKLLEYSSQVHEEINEISSKIEDDFLSLKNQNHWYMRTVQKSIETLEKEVLQRKKSKKNIEMAQLESNDTINHSKTELSLMSQDESINDDYGSIYSRFVQIKDRLDQLRFKKLYQLIGIFHSTDLFNSDRGYIYFEKPSSVNDVINRLKLKPLNIEILLRQAGESTKHREYVNSQLGYYLLFLHLTAIQIFKAPLPYRLMYYGSTSVIDSQYPLYFTDQMISKHQAKLIKAIHYFNADILQFKQILENYRPT
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
Subcellular Localization:
Cytoplasm. Membrane, clathrin-coated pit. Cell junction, focal adhesion. Cell projection, axon. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
Sequence:
MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIMTIVDELGKASAKAQHLPAPITSALRMQSNRHVIYVLKDTSARPAGKGAIIGFLKVGYKKLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPSPKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRSPTPSLRATRHSRAAVVDPIPAAPARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNSPDRGPLRPFVPEQELLRSLRLCPPHPTARLLLATDPGGSPAQRRRTRETPWGLVAQSCHYSRHGGFNTSFLGTGNQERKQGEQEAEDRSASEDQVLLQDGSGEEPTHTVAPRAQAPPAQSWMVGGDILNARVIRNLQERRNTRPW
The following text describes a protein:
Function:
Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Subcellular Localization:
Cytoplasm.
Sequence:
MPSLVGRDVGHTGYGLMRMTWVPQPPPQEQCFEALNTALAHGSNFWNAGELYGTPEYNSLHLLHSYFAQHPENADKVVLSIKGGLKPGQLVPDGSEANIRRSVDECLRVLDGKKKIDIFECARQDPKTTVEQTVTVLAQLVKEGKIGGIGLSEVDAETIRRAHKVHPIAAVEVEMSLFDLTILQNDVAKVCAELNIPIVAYSPLGRGVLAGAFTTAADIPDGDFRKTLPKFQDEAMKQNIKLVNEVNDLAARKGVAPVQIALAWVLTLSGKPGMPTIIPIPGGTTSAKVAQNLQAPRLTDAEMAEIDAILKRNEIVGTRY
The following text describes a protein:
Function:
Catalyzes the exchange of ADP and ATP across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSGGYVDEIIKSPFVATRQATILQRSRAPVLIQSTSEALLEKKTTSFVVDFLMGGVSATVSKMVAAPIERVKLLIQNQDKIIKSGRLSEPYKGIADCFTKTIKDEGVLSLWRGNTANVIRYFPTQALNFAFKDYFKRMFNFDKERDGYWMWFGVNLASGGAAGASSLLFVYSLDYARTRLANDAKAAQNGGERQFNGLLDVYQKTIKSDGIPGLYCGFTISCVGIVIYRGSYFGIYDSLKPVVLVGNLQARPFGWSNRLNGANGAFYGQIDMLKPTVPRVGLWFGGAVGQKLTWHPWEAGDHLSIACLYRRCHLAWPFDWSNRKNGSNRSFWGKIGDPRFWGGPGVRRCCGSKIDLGMPGILRSILVLPVCMDEVIWLVKRVKQWE
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAQMFPSVPGYDGPFSLKDFLHNYIGLQLRWSTPQENSTTLPPSNSNVVVVPPTGNFHVVVYVSRSAPPPQRSVRSVAVLSSCSNKMDGDHPQPSVPTHFHGRPLTSSVLKHPFWDALFSQIGPTAVSFIVLWAPIVVQFEASGGGLQVLGPPLKRSASCAVKRQPGAGWWEGKLKVSRTETLTQNDPHCFCIEGTSSPVALYRLNVPRLHLVEQSPLRSTADARHAVTLILEQLWIEHHKSSCSPSSDRDISQRLCGVATGSATNCCGDSCVVLAQARNQVNAVFPYTLLPVHDDAVSGNGTVKEYLIHVLHCALGSVCRMNIRGAAIKHTEFLEKRGKSVTSISQKAQTAGQENKMRAIPVGELTVPEPVVASYLETLFNMMWWRVPPRFVGGAVTADRVKFWGEEGTVLTRLREVTVDWLCCGRHEVFLLSHFLDGVPVSRIPWLRGFYTKEPARKRRSMIQQRVFLQLVLFLYQCVVPFLIRRSFHVACTSKSPYIFFFIPRAVWVRLTRREMRRVCIRRVKRMRSDTLSDPQMRGHAGLPPMALERVTSEGLMQLIGPSSQPVGDDSGGVSDVCKLRDSSSPLLYSDVRFLVDGSKLRPIARPRFGWQRSLLKAADGVGSSTLASALAKAGKYLATDGKAMWPSPNSAVLRDALRCLDAGVEERRITTGARQRAIGSHNDEYIEVRSFIQCARQFCTIPTLVQGETSAALLADATAVTMVRGDAARCYDHLPQEAVVNIMRGLVTHETYYSLKLTVVTLTTVKNVSKKTRSSHAESQLSSMKETNGSTVKHRKLQLSKRVKLVPGRYVQEGVLYGIARGCIAYEEQSVGSDSLVSGEEIRSVLQKHLQSHLVMLNGKMYIQRMGINQGSAVAMLLCDQLLERVDAALSSILSEHEEPALLLRRVDDVLVVTLSRAAASRCEDALRSGWSEIGFFCQEEKLRRVTCGQPVRWCGLLWDPVTLEFAVDWARLAKMMPYLAVRPRTGCEPLLSSLRFIRILRLRTPMTALCRQINSKSRVVQTLYEIGLLWSRFFLDKLKANAAFFRPHVRTILQPLALATATLRRLVRKHSFDLQRLGSFCDVTDVEVRLCISAALYHTLHQRLAFMIGRMSSVGKKKFLILMTAVLKRKMGELGSRINRNNQMESSLPSAADLLLVEGGDGVVSRGLAAVRFRPVETVRFQGCATRSA
The following text describes a protein:
Function:
Protects the bacterial cell from host peptidases.
Sequence:
MKHLRVVACMIMLALAGCDNNDKTAPTTKSEAPAVAQPSPAQDPAQLQKLAQQSQGKALTLLDASEAQLDGAATLVLTFSIPLDPEQDFSRVVHVVDKKSGSVDGAWELAPNLKELRLRHLEPERVLVVTVDPAVKALNNATFGKSYEKTITTRDVQPSVGFASRGSLLPGKIAEGLPVMALNVNHVDVNFFRVKPGSLASFVSQWEYRSSLSNWESDNLLKMADLVYTGRFDLNPARNTREKLLLPLSDIKPLQQAGVYVAVMNQAGHYNYSNAATLFTLSDIGVSAHRYHNRLDIFTQSLENGAAQSGIEIVLLNDKGQTLAQATSDAQGHVQLEADKAAALLLARKEEQTTLLDLTLPALDLSEFNVAGAPGYSKQFFMFGPRDLYRPGETVILNGLLRDSDGKTLPDQPVKLEVVKPDGQVMRTVVSQPENGLYRLNYPLDINAPTGLWHVRANTGDNLLRSWDFHVEDFMPERMALNLTAQKTPLAPADEVKFSVVGYYLYGAPANGNTLQGQLFLRPLRDAVAALPGFQFGNIAEENLSRSLDEVQLTLDKGGRGEVSAASQWQEAHSPLQVILQASLLESGGRPVTRRVEQAIWPADTLPGIRPQFAAKAVYDYRTDTTVNQPIVDEDSNAAFDIVYANAQGEKKAVSGLQVRLIRERRDYYWNWSESEGWQSQFDQKDLVEGEQTLDLNADETGKVSFPVEWGAYRLEVKAPNETVSSVRFWAGYSWQDNSDGSGAARPDRVTLKLDKANYRPGDTMKLHIAAPVAGKGYAMVESSDGPLWWQAIDVPAQGLELTIPVDKTWNRHDLYLSTLVVRPGDKSRSATPKRAVGLLHLPLGDDNRRLDLALESPAKMRPNQPLTVRVKASVKHGEMPKQINVLVSAVDSGVLNITDYATPDPWQAFFGQKRYGADIYDIYGQVIEGQGRLAALRFGGDGDDLKRGGKPPVNHVNIIAQQAQPITLNEQGEGVVTLPIGDFNGELRVMAQAWTADDFGRGESKVVVAAPVIAELNMPRFLAGGDVSRLVLDVTNLTDRPQTLNIALAASGLLELLSQQPQPVNLAPGVRTTLFVPVRALEGFGEGEIQATISGLNLPGETLDAQHKQWQIGVRPAWPAQTVNSGIALAPGESWHVPEQHLANISPATLQGQLLLSGKPPLNLARYIRELKAYPYGCLEQTTSGLFPALYTNAAQLQSLGITGDSDEKRRAAVDIGISRILQMQRDNGGFALWDENGAEEPWLTAYAMDFLIRAGEQGYSVPPEAINRGNERLLRYLQDPGTMLIRYSDNTQASTFAAQAYAALVLARQQKAPLGTLREIWERRSQAASGLPLMQLGIALNTMGDARRGEEAITLALNTPRQDERQWIADYGSSLRDNALMLSLLEENNLRPDAQNALLSSLSEQAFGQRWLSTQENNALFLAAHSRQASAGAWQVQTSLEAQPLSGDKALTRNLDADQLAALEVTNTGSQPLWLRLDSSGYPSSAPEPASNVLQIERQILGTDGQRKSLSSLRSGELVLVWLTVVADRNVPDALVVDLLPAGLELENQNLADSSASLPESGSEVQNLLNQMQQADIQYMEFRDDRFVAAVVVNEGQPVTLVYLARAVTPGTYQLAQPQVESMYAPQWRATGASEGLLIVTP
The following text describes a protein:
Function:
Transcription activator. Binds the promoter core sequence 5'-GGNCC-3'.
Subcellular Localization:
Nucleus.
Sequence:
MGDAGGHSHHHQHGFQPQLLSFGGVGHHHHLHQFTAQPQPPAASHTRGRGGGGEIVPATTTPRSRGGGGGGGGEIVAVQGGHIVRSTGRKDRHSKVCTARGPRDRRVRLSAHTAIQFYDVQDRLGYDRPSKAVDWLIKNAKDAIDKLDVLPAWQPTAGGAGAGNAAAPPSSSTHPDSAENSDDQAQAITVAHTAFDFAGGGSGGTSFLPPSLDSDAIADTIKSFFPMGGTAGGEASSSTTAAQSSAMGFQSYTPDLLSRTGSQSQELRLSLQSLPDPMFHHQQHRHGGGGGGGNGTTQQALFSGAANYSFGGGAMWATEQQAQNQRMLPWNVPDPGGGGGAAYLFNVSQQAAHMQAAAAALGGHQSQFFFQRGPLQSSNQPSERGWPETVEADNQMSHHQGGLSPSVSAAIGFAAPGIGFSGFRLPARIQGDEEHNGGGGGNGDKPPPPSSVSSASHH
The following text describes a protein:
Function:
As a component of tight junctions, plays a role in paracellular ion conductivity.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell junction, tight junction.
Sequence:
MKNTSGHREPRTRPRERDPDRRPHPDRDHHVERSRDRGGDRHRERNGDVRGNGDRRAGREQRTDRDQRQDRHRDAGHRASEQRALEKSRQSRARPEPWGPSWDAAPTPGPAPWGPRELSQKHGLGRRGLESERASERYVPTYSVPALQEEEYYQSEAEGLLDCHKCRYLCTGRACWQMLKALLNLLILACSSVSYNSTGGYTGITSLGGIYYYQYGGAYSGFDGADGERAQQLDVQFYQLKLPTVTAAMAYSGALMTFSCLTLLAGALRVPWHCPLWLVIEGLMDALIAGAYVPGLYFFFQHLSAAYSSDVCKERETLYQSKGYSGFNCGVHGGDIGAGVFAAMAIGVFAVGAVLAFRGYRKVKKLKEKPTEMLEF
The following text describes a protein:
Function:
Along with apicoplast pyruvate carrier 1, forms apicoplast pyruvate carrier (APC) complex, which transports pyruvate into the apicoplast and may also transport amino acids like methionine, serine, glycine and tryptophan with low efficiency. Required for maintaining pyruvate-dependent metabolic activities in the apicoplast, such as synthesis of fatty acids, isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP) and methylerythritol 4-phosphate (MEP). Required for maintaining the integrity of the apicoplast. Required for normal parasite growth.
Subcellular Localization:
Plastid, apicoplast. Membrane; Multi-pass membrane protein.
Sequence:
MSAFPASPQPSAFPASPQPSAFPASPQPSASPVSPRHCVSPSSGTLPSSSSPSVSSCALRGLSSSSSALSRPPFSSFPASPAFSRRCMLTESEMGKTRSLKWLRFRCILGACLLHFCLGGSHTIGNLLPYLIGFIRNAQATSAVSYKDGLSIYAWAIICQGVGGFLGTTLEKKAGTKKTAFLGSAWMTLGLALCGVCTHDLSLFLIAYGVVTALGCGVAYPVPLAATLKLSPAEDKGWVSGLLFFARGLSVCILCPFQSFFLHQPPEVFLSLIPAPLLPYLSSVASDTASASRLSSLNGKRAAPLPSPGGERFLTDQAVLDRLPALFFVMAGVFACIQLLGVLLLVDPERTSAADEAAADAAERQKLLYEDPQGASRASAGRSSSCSASQVFASLVLTPQDICSSPSFWRLFLMLLLSWQSLFFVQLFWKVLPLYPEASLAASAAAPAPLDSLFASVVRRVPRALASASRPDPRALHAAADAWSLTGSSWSFANDFFLSCLGGLLGALCCFGRLLWGYIGGGIGYMRSTVVMNALTAPCLFALSTYALQSPQLYAACLALVHVCHGGIFSLFPSVTSDLFGHKNVGPVFSLLFAARLAAVALAAIWINIALTYGNLHMVVGALGVCHLVSIGTTFFFHPTDALPYRFPTYSP
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVAIVRIMRKLEKDRIESSCLFAKKRKNALIVMRNYIKLRTSSNLLELFISNVNSLIHQTVKTAIRRYKLENERKRHCDLADDTKPSMKRKISLHKGYQIIGKDSRNIWFVGQFGKGAEEKEEEEDDDEDCENNWRNDYPDESSWFYNADPNFSCYDYGRDYG
The following text describes a protein:
Function:
Required for normal mating-type switching.
Sequence:
MNVNKKQESIPVNTGSESISSNDNERFEQGKGVGSNLGSHFFEPVEYYYSDGKPMNQTEASQMKGTFSRDFSLNEMNNEFITDSFFCTTTPDPKTESPSFVKYNAHCDDHPEISGHVSSNDKDFAYFEDKSENQPLVTLPNENNQVIEPLSSQSCKSQLSTQNYSESDFGWNQLCDLDPIFKSLAFTDDTNLFPAFADSEAALIMLKKREMTRVKHRAGRPRKYSYVNKDLNFEEGLPRRRGRPTGWRKYPEKEEIYPTLSPRIKKPRKVFDAVVIPVTIKPSIYTEPSLPHHIDWNNGCSEEFDFEPSREDEDFPDLTSDSTGQDPLSSEPTIFDISPLPSDMEPTFSENSLITINKMAIEERKQSRRLEQPLAESQHQEDLLNPYGVDQDFDETCINESEQQATHIPNSSIKFNYDYTPPKSATSHKHKRVDLLASRKENVWTGLYGKVQTEMVSNRGEAVLNENNSKNRTNVTKPNSYKNSVLSIGNNHSNHSNIIKPNTYKNTILSNENNTPNYSNVCLSTSLINRSLPSLKSTMHPGVNKDLITRPFKNVNKMSVRKALIKPFHPPISKISRTRLTVSSPERLYCAKPISMATAPSETDSKLINRIRNLELEIGGLKEQLSVVELALDTDKNSKQIQVVERKIQNWRKSAQLAVEVLFPVFSLKFTTMLQEVPQSVLRTSANDLRTKPCSIGTYLEQLQIPFHLLQYNSETESWDLE
The following text describes a protein:
Function:
Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKTLSGLPLLLLLLLSTPPPCAPQASGIRGDALEKSCLQQPLDCDDIYMQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWNDYKLGFGRADGEYWLGLQNLHLLTLKQKYELRVDLEDFENNTAYAKYVDFSISPNAVSAEEDGYTLYVAGFEDGGAGDSLSYHSGQKFSTFDRDQDLFVQNCAALSSGAFWFRSCHFANLNGFYLGGSHLSYANGINWAQWKGFYYSLKRTEMKIRRA
The following text describes a protein:
Function:
Mediates the transfer of lipids between membranes at organelle contact sites.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MRTRFRLEIKCQNYNEKKEMDIVTIQSQFKSLQVSDENKPIIVLSKNTPFELEAKIGKESELIIKMNRPQLICIPRDINKLQEYWGQILKFIGGYLKVNTETPFKVNIDISDGLILFEDNQERCVMALEYSTKGNVVTQNTIQHLDKKIITNELKSLCLEFNNISMKSTQHEILSKTKFTLSISKTSQNHQFQPNLLINFTSNNLHFFIGVYEFFILQHLFQQLNDNLKVFFKQNIKDSIQRKCTIYQPFVSQQKPIILPIKTAPSLRSYKVNIPSITLKIATDIKCIKIIINDFNIDGKSGVLTNVFSLEIDCFNADKQKYESLIDMTTIKCAWIGTSTRIFFEKNLNVNITPHAILSISSLLNVVNSFNREINDISQIITPKQEEQLPILQPFSLINYSGMDLEIIISNMKLFVKMNSSIDLPEGSLLQIKMVGYKDISFTIGGIKQIIELTSLKTNKHGGYLIIERNSLRELKISSSISVLNQTNEKVKVYVSTPSKPNIISFSLQPQGIYYFQPIFSRTYFSIAVTPINEPIPLPNPSYTGHIPTETSEFNKQWEAPITKLFGSAPVKILMISPKVGVPQLNKEKKYIRTVNFIIQHPYIFHSHLPSTLLLTLFDTNKTQLIIPPFGTLSYAHNNERLSGFIKILNDCIDGFTMEPTILLLNSEEFYLFPSNLRSRRIVFNSPTQVNYILMRFEENENYPTNVHFEINQFVQNQTLIPLIYNNISLPTNGSLVPMTQFCEDNIKINNKNINGILMLKSDQNNSNNNKLKEVLLPNEENGIVLLGNPPIEIVYSKSIEEKSNKEIIILKQRYVIHNRTEHKIKFYCSQFPHGTNVMAKGYAPCNVSGEFEMSLEIEINKELFESEQFKINKEVNCQMILSSKNERYIIISINITLNQMEYIICIDEIEKYYLCIQNYTNIPITFAQTNTIHTYTIQPNQSLPFAWTVPTLKHTLQLYDKNNTIINPIISSQHHQLEFNNNEKKKIEIVYSSFSLEKSTTFINFTLTSVYENSLNTIPLYDFNIMFSNFGISILINDNEFLYISLFNMQLKLVQTFSHSGIEFSIDYIQIDNQDVTLINSKPVILSPSPSDWIQFNKQNYFHVGCKLLRTGINELTSHSLHIVEMTVAIQTTEIQIDPAFLARAIEIYSIYHSIVKNIFKSSITKQNVETNKFYIKIEKFICNSIAFHLTINPSQKEPPPLSESATTLHHLTQMNAVKNVPIVIHKFSSKPIEMELIQFIKIIIKYFSKEIDFPSIKKQWASGIIGLNNIRLSYETVDYKTFERYVIPMKLFKDVEKKIPEEFKRALNDSFVKSVNQGVDLLTTGIASGVKGIWTTPSTMYQMAKEKSSLLGPIGFVSGIVAGVTGVVVKPIDGVFGLVQNLGMGISGETCGNIAEDRIRFPWYVAGGSYNEKSATGWSMMMECNEGKYQHLKYFDCVRKVSERKIEVIVITETHLLFITKNSGEIPYLQKIIPFEYFKGIFTQSLSLILFYYENNKLSDLEIIGWTPIESNALRVIIENNPIKISINKGTLFLRSIPKS