lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Putative O-acetyltransferase that transfers an O-acetyl group to the O antigen.
Sequence:
MILKLAKRYGLCGFIRLVRDVLLTRVFYRNCRIIRFPCYIRNDGSINFGENFTSGVGLRLDAFGRGVIFFSDNVQVNDYVHIASIESVTIGRDTLIASKVFITDHNHGSFKHSDPMSSPNIPPDMRTLESSAVVIGQRVWLGENVTVLPGTIIGNGVVVGANSVVRGSIPENTVIAGVPAKIIKKYNHETKLWEKA
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Sequence:
MELIAVVAMDSRRLIGRGDGLPWHCPEDLSAFKALTWGQPLLMGRRTFESILARRGKPLPEREHYVLTARRGPSFPTVRYICSPDQALALPVERLFVIGGASVYAQTADQLDTLYLSLIPGLHTGDVFLPDLGNRWAVEIIEKFQTFKRWRLLRSPSVGFDWSQLVEGG
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKILKNRVRSYFSGTHDSKTQRLVQEIVDFEYIVTSSNVEALLLEINLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVKKDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVCLYYHLGQCLAPCVFDVEASKYKEMQDEIVAFLNGGYKTVKNDLMKKMQEAAENMEFEKAGEFRDQINAIETTMEKQKMTMNDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKANHIPPQEIYLPNDVDSEAVQAVVPDTKIIVPQRGNKKDLVKLAYKNAKIALNEKFMLLERNEERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAMVTFLDGKPSKNDYRKYKIKTVEGPDDYATMREVIRRRYWRVLKEGLPMPDLILIDGGKGQIDSAKDVLTNELGLDIPVAGLAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSILDGIPGVGPGRKKKLLKHFGSMKKLKEASIEEIKEAGVPLNVAEEVHKHITAFNEKAKNTEQK
The following text describes a protein:
Function:
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Sequence:
MERNRKNLSFVAPKMAWLSSKRMPLRSSKGNLGPQRPENIPTHLPLPSTRPSSTCKIIVSLLPPAGLFILLWVLKESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVSTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDVEGLDPAPTASALTPRAGTGPIIPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK
The following text describes a protein:
Function:
Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MATLHRVSRLCTRRLALPSQRSSWLKLTTLSPRPFLTHPTTLPVTPWYSLRHSFHSTSGVRAELEETSRNVRKSSENLHNAAKELGSKSEGEKTVTDTDSVTDTKPEDKPRWKRPTKEEMLSTATGFYNRMRVRFKWALFRQDRPTNMDDISAFLSWFMVGNIVWIVLGTTTFFSLVLFTMNTVFAQEWIASKIGNIVSRQTGMSVVFEEAIVPHWKGGVIQFRNVFVSRRPGGGHKARKGSQGEAAALAGEKQYGSLSSAPPDDDGNYTQFDLTIETVDVTLSFSKYMSGKGILKEVEVKGIRGVVDRNHLRWKRNQDPRNNRNVHKTGDFEIENFKLEDALVSLHQPGRDKPFNVSVFNMELPQLRKHWLFYDLLSANNLSGSYDNSLFTIHPRQIHGVPSSQLNEDKTWKKVSRLRVDKVNIEHLNRGVQGAFGWIVSGNVDLLADLMLPSDTDDYTMSEMMKDVLERWEHTLMRRGRKSGDPISMPGGSHSDEPLTTSAQAAQAQKYLVLDLRVQLNDVRAAVPLFNTDLNYVNNAMIRPIVAYINSRDTYIPINCRVVKKVDDFAGSWTMYDSGLMDNISEEVYQAFAENVSNDEARHRRMKKVSLWSLQLAAQLLLLSIGTIA
The following text describes a protein:
Function:
Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes.
Subcellular Localization:
Nucleus.
Sequence:
MGLTGRKSEKGPVCWRRRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTDILNQEWKLRRIQPVHIMTPVSSLRGTRECTVDSGFSEFSRQVIPLKTLNAVASVPVMYSWSPLQQNFMVEDETVLHNIPYMGDEILDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALNQYSDNEEDDEEDDHHDYKFEKMDLCDGKDDAEDHKEQLSSESHNNDGSKKFPSDKIFEAISSMFPDKGSTEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFQATPNTYKRKNMENLVDSKPCGIYCYMYMVQDGMVREYPAGVVPERAKTPSKRSTGRRRGRLPNSNSRPSTPTVNSETKDTDSDREGGADGNDSNDKDDDDKKDETTSSSEANSRCQTPVKLKLSSEPPENVDWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIARAPAVDENTPQRKKKRKHRLWATHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAAEHWDSKNVSCKNCSIQRGAKKHLLLAPSDVAGWGIFIKEPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
The following text describes a protein:
Function:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Sequence:
MASAECNRLVFEAVDEFSVAKFQSVRASYSQIDVLASLLQRDEDNQTPLEIAIIRGNVEFTDELIIFLQRCDRSVVESNLMSEAINQLFHPAFPIVKLIEQLINESNDSILNWLDIFVQVVLKSTSLSRPDKISALELVGASLPKYHGGSFAVIFRYWREAMKLRHLPAHGELPLPKTPYVGDISAASLVVFGPAEEIMTMEDLNLFEEDFVRDVFDQDEEVQQRGFDLLRRQSLLVIRRIASQADNGHPNACYILSLYEFVTEKMRINEENEDEDQDVNAIDIARYTVMNGIVFNTFLLILEQVTDGFDPKLLPRKSFDVFFKTLAFGSYWLSFMAKKPLGYPVREDILSHANLLAFTKLIGKIAKFFTKPIAMSSIDIADYEFEELLEYMGFNATESYHGFAKIIFDLVFVLKSISSRLSNREKQELEQYYSNYIRKYFPTRKTTALHVAVAEENLKTELIQFILQLGADPNEINEYGQTPLHILSGRKVAYLDKNIPIFKALLEAGTHRDTSEDNGDTVLDILKRNLERFRGSVDVEVEAEAYLSCLINAVLPLTCYCARVIRQNGIPFDGDRLPLDLQPFVSRHSDNGFIDRRRRV
The following text describes a protein:
Function:
Probable inactive acireductone dioxygenase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQIWHMEPFPCGDRRLPHHVFPPKKITTTQLGQLAGVQYYKVDLDDTASMKKRLSAVKTEKNVTFTDMFTVSETMLEFDDKMEQFYEPQVQKEDVISLVVEGTCYYDVEPEDDSWIRVQVEKGDLIVIPKGLSHRFTTTPQNFVKIQRFFSRKVEGNQG
The following text describes a protein:
Function:
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
Subcellular Localization:
Mitochondrion inner membrane; Lipid-anchor.
Sequence:
MFRAVSRAGSLLLRGSQVHYPRTWNREAQRCLSSGLPMNTVVLFVPQQEAWVIERMGRFHRILEPGLNVLIPILDRIRYVQSLKEIVINVPEQSAVSLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLTLDKVFRERESLNANIVDAINQASDYWGIKCLRYEIKDIHVPPKVKEAMQMQVEAERRKRAMVLESEGTRESAINVAEGQKQAQILASEAERAEQINKAAGEANAILAKAKARGDAIRMLAEALTQQNGNAAASLTVAEQYVLAFSKLAKESNTILLPTNTGDISSMVAQAMGIYGKMTQQQLAQSSPTLSDGTMGTETQGQSQS
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MRISSLLFLTFLAGIVQAQDFLAMFKPFLGGGGGGGNPFANPQAIGGLFQQFAGGNGGGFGQLLAGAMAPKPAPAAAGPRSAPAPTNEDYNTDIDVPAPKAKARAAPTPRRAQADAPPVYRQPRTKAEKIERFRNIARTFSPFVYEVNTTPAPHFDNFIWQQNAPAVTPEPFTFAPFSFPTLATVAPPAPGPGGPTLEPFLPTTASPKLLAHNTARMIREIASFSDGGRSRDQDFGAVQTLMQAFFEAVSSGNNGGAGAAAGAGTALGDAPMLQAHRDGTELGANRALTNKLFESDMVLTVKQMKAIVLAAQEARNPHGRKKRKVITGSVYRWKSVIPFRFKGGDAKWKKLIREGLGLWEKETCVRWSENGPGKDYVIFFRGSGCYSSVGRTGGSQLISIGYGCEDKGIVAHEVGHSLGFWHEQSRPDRDDYIHLRKDWIIKGTDGNFEKRSWEEIEDMGVPYDVGSVMHYGSNAFTKDWDQITIETKDSRYQGTIGQRQKLSFIDVKQVNRLYCNSVCPVALPCMHGGYPDPNNCAVCKCPDGLGGKLCGRAAKGTDHDKCGGELTATAEWQEMVYKGKRTCNWKVKSPSGGRVRLVLTELRYQCAPACKAYIEIKHNTDFQQTGFRVCCFNKTYDVISDQSEALILSNANIVDYEVSYKLQWIQDNGKALPPPKPTSTWVPGKENRPFRGVENSGGTIEKFILQAIPKIRDSHRPLESITSIVAEYGLATLLGISHNGK
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MAASSPSLLLPLGSASRNGLTTKNPNSSRYIAARVIASETREQSCKISNLSSRREAMLLVLGVSGGLSMSSLAAYAAGLPPEDKPRLCEAECEKELENVPMVTTESGLQYKDIKVGRGPSPPVGFQVAANYVAMVPSGQIFDSSLEKGLPYLFRVGSGQVIKGLDEGILSMKAGGKRRLYIPGPLAFPKGLVSAPGRPRVAPNSPVIFDVSLEFIPGLDSEEE
The following text describes a protein:
Function:
Cell adhesion molecule involved in associative learning and memory. Acts as a regulator of GABAergic synaptic transmission at neuromuscular junctions by regulating GABA synaptic vesicle precursor transport: possibly functions as a cargo adapter for unc-104-mediated transport of synaptic vesicle precursors. Promotes localization of isoform c of daf-2 (daf-2c) to synaptic regions by acting as a signaling adapter between klc-2 and daf-2c; [Isoform a]: Acts as aregulator of glutamate signaling in the sensory neurons by inhibiting the activity of command interneurons, thereby negatively regulating motor circuit activity and locomotion.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, axon; [Secreted calsyntenin-1]: Secreted. Synaptic cleft. Note=Released in the extracellular space following proteolytic cleavage.
Sequence:
MRTAYFIFVGALLGVSYAKHHHAARAPIINLQGAEELVAVVREDENIISTVPDFAILSETGPVCNYLLTSQNNEPVPFDIQVVDKYTGAAVLRVKDAATLDCKKPEYNLQVQAVKCDNDNVKSEGVSLKIRVKDTNNHAPEIENPWYTFHVEEGKVVEEVGVLKASDKDCGHPNGEICEYEITNGLKELPFAINNHGVLRTTQPLNFTQSKSYILTVVAIDCAMRKSKSSLVTVHVDEKCVQGITAMNERVNYAPGVGSKLLLPDVSLEFCEKETICEPKSVQSVIELRAGHVTQGCARDTVYDNQTIQSCGLSTATVKLLNEEALTSSAENQILADQGIEFDGARGVTVSDENHQGLIPDHFTLSFSMKHAAGTKDEQSNKQNILCESDDFNMNRHHFSVYIRHCKLEVVLRREAGATSDFRAAEWRWSMPEVCDNEWHSYSLLFNGIDDVNVIVDGKSFKADERNPEILDDWPLHKTKATKTKLVVGACWHGRQQKLAQFFRGQLSSLYLLSGAVESERAIKCAHTCPEQLQFTGVDELLESQSATFSPDQTSLTLKAETSKQIGQMLKRVAYVNTQEKPAPGHRVFLVETEVTCKQDDKKMKLPSSKGYVFVQQAAEPTLSISASSQLKSNQHMVKVGQAMVPDLTITISQNNADGELEDVTQSHKIDYCKMHLQPARDMDVEYFSSPASLIAALNIEFEHDKDGILLRGEESAQGYKEVLSKVHYFNTRPESYAKRVYTVQCAMLKGRVLSNQLFVTMTIDGVTTTTSTTTEAPAPAQPDPIQFNFNSGETALDSLELIERHFEPAFDQLGSSRLQNILEMDLPRPKALLSHHGYDVGQGAIAGGAVAVVVVVCVGFLLVLLVIGVLKMRDTPMPRRRRQKRQSDGGMHWDDSGMNITVNPLDDVEKNGGAIDEFSDEEEEEETDGESECSYRDEEDDVSEDEEDQTEVLPHLDANQRVVGGLEWDDEDAISTNARSYRV
The following text describes a protein:
Function:
Calcium-regulated non-lysosomal thiol-protease.
Sequence:
MACGSGRVTIQLVDEEAGPGTRGPKPYRGQRYEAIRAACLDEGILFRDPYFPAGPDALGYDELGPDSEKAKGVEWMRPHEFCAEPQFICEDMSRTDVCQGRLGNCWFLAAAASLTLYPRLLSRVVPPGQGFQDGYAGVFHFQLWQFGRWVDVVVDDRLPVREGKLMFVRSDQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQDTPGLFSALRHALAKESLVGATALSDRGEYRTEDGLVKGHAYSVTGTYKVTLGFTKVRLLRLRNPWGRVEWTGAWSDSCPRWDALPTEWRDALLVKKEDGEFWMELKDFLRHFNTVQICSLSPEVLGPSPAGGGWHIHTFQGRWVRGFNSGGSQPGTETFWTNPQFRLTLLEPDEEDDDEEGPWGGWGAAGAWGPARGGRIPKCTVLLSLIQRNRRRLRAQGLTYLTVGFHVFQVPPGPQLLGLWDSPRSRALLPGLLRADRSPFCARRDVSRRCRLRPGHYLVVPSAARAGDEADFTLRVFSERRHAAVEIDDVISADLHALLVPYVPLELGLEQLFQELAGEEEALSAAQLQTLLSIALEPDTRTPREIGLRTCEQLLRCFGNGQSLTLHHFQQLWGHLLEWQATFDKFDEDASGTMNSYELRLALNAAGFHLNNQLTQALTSRYRDSRLRVDFERFVSCAAQLTCIFRHCSQHLDGGEGVICLTRRQWMEVATFS
The following text describes a protein:
Function:
Seems to play a role in the inhibition of host innate immune repsonse.
Subcellular Localization:
Host membrane; Multi-pass membrane protein. Host Golgi apparatus. Note=Also localizes in the host perinuclear area.
Sequence:
MAFSASLFKPVQLVPVSPAFHRIESTDSIVFTYIPASGYVAALAVNVCLIPLLLLLRQDTCRRSIIRTMVLYFLVLYNFLLAIVLVNGVHYPTGSCLIAFLVILIILWFVDRIRFCLMLNSYIPLFDMRSHFIRVSTVSSHGMVPVIHTKPLFIRNFDQRCSCSRCFYLHSSTYIECTYISRFSKISLVSVTDFSLNGNVSTVFVPATRDSVPLHIIAPSSLIV
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVIDAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKEQMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGMMYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVLLAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKMNPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLLYTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETFLSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK
The following text describes a protein:
Function:
ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection. Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MPGKLLWGDIMELEAPLEETESQRKERQKSDRRKSRHHYDSDEKSETRENGVTDDLDAPKPKKAKMKEKLNGDTEEGCDRLSDEFSKSHKPRRKDLSNGDIDEHEKRSKRVSSLNSSTHKSSDNKVEETLTREQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDVTRKLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDILHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNSRQRSGWSSGRLGRSGRSGGRSGGRSGRQSRQGSRTGSRQDGRRRSGNRNRSRSGGHKRNFD
The following text describes a protein:
Function:
Might be involved in early recognition of growth promoting fungi. Appears to be specific for P.indica.
Miscellaneous:
MISCELLANEOUS: Induction of At5g16590 is not observed in mutants devoid of PII-2, another leucine-rich repeat protein normally associated with the plasma membrane microdomains.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MKNKTNLGLSVFFFFICLVSVTSDLEADRRALIALRDGVHGRPLLWNLTAPPCTWGGVQCESGRVTALRLPGVGLSGPLPIAIGNLTKLETLSFRFNALNGPLPPDFANLTLLRYLYLQGNAFSGEIPSFLFTLPNIIRINLAQNNFLGRIPDNVNSATRLATLYLQDNQLTGPIPEIKIKLQQFNVSSNQLNGSIPDPLSGMPKTAFLGNLLCGKPLDACPVNGTGNGTVTPGGKGKSDKLSAGAIVGIVIGCFVLLLVLFLIVFCLCRKKKKEQVVQSRSIEAAPVPTSSAAVAKESNGPPAVVANGASENGVSKNPAAVSKDLTFFVKSFGEFDLDGLLKASAEVLGKGTFGSSYKASFDHGLVVAVKRLRDVVVPEKEFREKLQVLGSISHANLVTLIAYYFSRDEKLVVFEYMSRGSLSALLHGNKGSGRSPLNWETRANIALGAARAISYLHSRDATTSHGNIKSSNILLSESFEAKVSDYCLAPMISPTSTPNRIDGYRAPEVTDARKISQKADVYSFGVLILELLTGKSPTHQQLHEEGVDLPRWVSSITEQQSPSDVFDPELTRYQSDSNENMIRLLNIGISCTTQYPDSRPTMPEVTRLIEEVSRSPASPGPLSD
The following text describes a protein:
Function:
Probable multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass (By similarity). Has a role in embryonic tracheal development where it localizes to the leading edge of actively migrating branches. In these leading cells, enhances formation and/or maintenance of filopodia which may drive branch migration and elongation by cell-cell intercalation. The function in tracheal morphogenesis is dependent on its inositol polyphosphate phosphatase activity.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Basolateral cell membrane. Cell projection, filopodium. Cell junction. Note=Has a dynamic localization pattern during tracheal development. During early tracheal invagination (embryonic stage 10), localizes mainly to the apical cell membrane. During the primary tracheal branching stage (embryonic stage 11), found mainly at the basolateral cell membrane. At later stages (embryonic stage 13-15), also localizes to cell-cell junctions and filopodia.
Sequence:
MRLLILLLLPLVAIAQDDYCFSKDTSRLQTRQFSSKTAYQIVKGTDIDKQYLVPGCQPQKMWIFHRHGTRLPKKSMINKASRVAELRDLIINNYQVARTKPETDALCQTDLIAIKLWKWNSSITPDMEEYLTAQGYEDLRGTAKLYQRYYPTVLTANYNDTYYQFRHTDTQRTTESFKAFAEGLFGSQNAAHPVEIPKQDLLLRPYDYCSSFKNVNYKDEGSEYYKFHQSKLYNDTLADISTRLGFLYTLEEADIKLMYDMCRYEQAWNVDRNSVWCGAFLPEQITVFEYLEDLKYYYGSGYGFPENAHLNCRLVQDLLTHLSNPVSPHVVAHFGHSTGLLTLLTALGIQKDDIKLRADNYDSLTSRRWKSSLIDPFAANFVAVKYDCPADLDREKVVFFLNQQAVQLDWCSVGLCKWSDVLEKYKTIADADCGEYYCRTGGAPSLGSGVGGLLATTLAAMLVYLMH
The following text describes a protein:
Function:
Effector E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. Interacts with IKBKG (NEMO) and TNIP1 (ABIN-1), a ubiquitin-binding adapter protein, which results in TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG. Consequently, polyubiquitinated IKBKG undergoes proteasome-dependent degradation, which perturbs NF-kappa-B activation during bacterial infection. Mediates polyubiquitination of host U2AF1, leading to its proteasomal degradation. Catalyzes 'Lys-48'-linked polyubiquitination and subsequent degradation of a subset of host guanylate-binding proteins (GBP1, GBP2, GBP4 and GBP6), thereby suppressing host cell defense. In contrast, host GBP3 and GBP7 are not ubiquitinated by IpaH9.8. Uses UBE2D2 (UBCH5B) as an E2 ubiquitin-conjugating enzyme.
Subcellular Localization:
Secreted. Host cytoplasm. Host nucleus. Note=Secreted via Mxi-Spa type III secretion system (T3SS), and delivered into the host cytoplasm. Transported into the host nucleus. This transport is independent of cytosolic factors, but dependent on temperature and partly on ATP/GTP.
Domain:
The LRR (leucine-rich repeat) repeats are involved in substrate recognition with target proteins.
Sequence:
MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQTWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDIDMNGGRDRIAPMFKDRHVLITGGTGFLGKALIEKLLRCCPEIGQIYLLVRSKKGKLPRQRLEDIFANPLFETVKGLRGLDTLISQCTVISGDVTEPELAISPEDRQLITEKVSIIYHCAATIRFDETLKKAVMLNTRGTKYMIDLAKQCKKLDMFGYVSTSYCHLNEKLLLEKPYPPPADPHKVIKAVEWLEEGVVDGMTKKILGDCPNTYAYTKALAEALVVESMDEIPAVIFRPSIVIPTWREPIPGWTDNINGPVGLLIGAGKGVIRSMYCDSDGYGDYLPVDFAVSAMCVCTWNYVGNQDHKRNIYHLVSSAEIKVSWEGIIERGKWIVANKIPLNGVLWYPGGTMKRTRWEHNLAAFFFHWIPAFLIDCLLYCFGYKPILWRIHQRIAKGFEVFEYYANNQWDFDNATILYLRTIINDEEKVKFKIDAGGVEIQEYFENCIRAARWYILKETDDTIPAAKRHMRVMWWVDKICKTLIYGGLIYYIGKALYSLLFASVF
The following text describes a protein:
Function:
Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.
Subcellular Localization:
Periplasm.
Sequence:
MKKWLLAAGLGLAMVTSAQAADKIAIVNMGNLFQQVAQKTGVSNTLENEFKGRAAELQKMETDLQSKMQRLQSMKAGSDRTKLEKDVMSQRQTFAQKAQAFEKDRARRSNEERNKLVTRIQTAVKKVANDQSIDLVVDANTVAYNSSDVKDITADVLKQVK
The following text describes a protein:
Function:
Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
Subcellular Localization:
Cytoplasm. Endomembrane system; Lipid-anchor; Cytoplasmic side.
Sequence:
MPLVRYRKVVILGYRSVGESPPRGEHRRTAALWPEEAHSRGNATQGGMEASLERGCRARMKDGGGKAGVVVVCGELQEAGAWKTSLAHQFVEGEFLEGYDPTVENTYSKIVTLGKDEFHLHLVDTAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRLPVVLVGNKADLSPYREVQADEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRCQLM
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MEVSKSFIDKINSEFTSSLHFGSPLPGSRTNEFDLVRGVLQILQGFSSCLFYWEKGIGQGYRARKGLYVAHLSQTSLGMVLDQFVYSATCLKLVELRLCEIEDMSGSSRSPPPTLRAFASSASAWLRVKQKLRDIALTEELKMNNSNTGTTPTILGLGNSLTRLCGGAEYLLQIVHGAIPIEGDTPLSSAETAVHILNHLYEKLNDACLVQGGEEDSYRMLLYIFVGCLLPYIEVLDSWIFEGILDDPFEEMFFYANKAIAIDEAEFWEKSYLLRSTQHKKLSAAHVSDLFPLTQKKMSGKVATKTRGQNEYDLVVCPLFLKDIAKEIISAGKSLQLIQHIPITSTLVDRHHEKEGCMTHQLSLSEIFCLSLTALIGHGDHMSEIFWKNDKIVSATSTEKLLVAYSEKIWHKFLVDALNNDMKVEQNLDLVLSSFCPENPTITVCQKVLQAKANTHDWNSLNLSKNYILPPLNDDKLRKAIFGGMGEDFMTAKGTNYACGFPFGDSRSQHGIKVVESLFPFPTILPSFKWKQEELMMSEVLPFQKNSTLVSKVLGWIQTVEPKSTPLPVVILRECLTFYIKKQVDHIGNQILSKLLYDWKLMAELGVLRDVYLLGSGDLLQHFLTVVFNKLDKGESWDDDFELNTVLQDSIRNSADATVLSSPDSLVVSLTKSDGDAQQTTTTTSSSSFIVSSPRKNHRAQVSGINDLDSLNFTYKVSWPLELIANAETLKKYNQVVSFVFCLFGEFDYLYANNKQVMNFLLRVKRAKFVLDKARRWMWKERGTTTVNRKHRWLVEQKLLHFVDAFHQYVMDRVTNNLLYSSLQSTPTLVYHSAWRELCEGMAAAGSLDEVIEVHEAYLLSIQRQCFVVPDKLWVLIASRINSILGLALDFYSVQQTLSSGGAVSAIKARCDKEVDRIHKQFDDCIAFLLRVLSFKLNVGQFPHLVDLVTRINYNNFYMSDTGNLITAPGSDSINFKLAKTL
The following text describes a protein:
Function:
Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILIDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARSFNNIMNFQRFLKFPDDPKVSGDFLDLVQSLLCGQKERLKFEGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV