lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSHFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQARPPLTLRTSLPGRRAGLLAQAPIADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQVGASPNIRLVQSHVTTHLAHRRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIILDCGEDEYCVPQLQLTDGSPSVGQIMSWSCRWTPANEGEGAYEAELAGTCPAATHAGLSNVEYGFERLICNQKKENETRLGNPMKKRRPGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPTPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLLSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVRTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE
The following text describes a protein:
Function:
Receptor which, together with svh-4, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. May play a role in axon regeneration following injury in D-type motor neurons.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MQIALVLLAIYGTTTTNTLRIDQCGENALGMQNGDIADSQITASSSFDKQSVGPQNARLHSELASGAWCPKPQINSKSYEFLQVTLNDTFLITSVETQGRYGNGTGREFASHYMIDYLRPGSQWIRYKNRTGHVYMDGNFDTTTPVIRVLDPPIVASRIRFVPSSKNTRTVCMRAEIHGCKHEGVTYYSTVPDGSRLDTLDFKDSMFEDSQIYTESGIKRGLGLLTDGFVAQASPFEKNQMNNSWIGWNRDTTDGRITILFEFEEVHNFTDVVLATFGNRIDGIDVIFSQDGKTFPLFSQISSSERQSLNNTSRRYDFRVPLHNRAGRKVRISIKFSSDWMFLTEVHFTSAANLTLLSEKIPPPSSAATQQLLVVCGIIFLTIFACVAYCVSVCLKRRQKNKSVDSNVKKDLIITHMGNKPTCHVFPSNGKLSNGHYEVANDILYARSQKSTLLSVSSKSTFSCRAIPPTWTDFNFPPPPEGREEHTYSQPVSPENSSNGSYKSVRKIQALKKYPSSALLIGKAIGEGKFTMIKECIIFGGLKCAHKSTKEEDCVHGTRALGDEIACLLQCGRHPRIVELFGVDESYNLLLEHVEYGCIRNFWMASEAPLDTEFLVRICKDIYSAMAYLESIRIVHGHFTPNNILMDGEFHAKVCSPRGPSHHAQLRYSAPESIVNNEFTHKSDAWAVATTVYEMAYQCRQRPYEELTNEQIVDNACALLDHQPNAVVPLMPTVFNYEILQLLTRCFRVDQLERPTFERLVKPFQD
The following text describes a protein:
Function:
C-S lyase involved in glucosinolate biosynthesis. Converts S-(alkylacetohydroximoyl)-L-cysteine to thiohydroximate. Functions in auxin homeostasis. Probably required for glucosinolate activation in response to pathogens.
Sequence:
MSEEQPHANLAVPAFKTEKEPITQTRNGQSSVWRFGGSDKAAKASTVTLRGVIYMLFDNCGKDVNKTILPLGHGDPSVYPCFRTCIEAEDAVVDVLRSGKGNSYGPGAGILPARRAVADYMNRDLPHKLTPEDIFLTAGCNQGIEIVFESLARPNANILLPRPGFPHYDARAAYSGLEVRKFDLLPEKEWEIDLEGIEAIADENTVAMVVINPNNPCGNVYSHDHLKKVAETARKLGIMVISDEVYDRTIFGDNPFVSMGKFASIVPVLTLAGISKGWVVPGWKIGWIALNDPEGVFETTKVLQSIKQNLDVTPDPATIIQAALPAILEKADKNFFAKKNKILKHNVDLVCDRLKDIPCVVCPKKPESCTYLLTKLELSLMDNIKDDIDFCVKLAREENLVFLPGDALGLKNWMRITIGVEAHMLEDALERLKGFCTRHAKKTETETESLQALKLSDNNLEM
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MDRIETVMRWVRRVSRVLVVVTALLLMVMGVRELLAGDAVFGTALIMLGVAGIPAANPFRSPSAGRADGLAGQSSREQFTSLVTQLIAAGFGLVAIIATLLIIFGPRALSDLGWTEYALHYTALGVVVVVGMVFLSILMLMRRLILPRLQQEIEERAQQLSERQSLLLAQLREAAAQEERNRLARDLHDTIKQQLFSINIAAATAQSLYERDPVGAAQHIQHVRDLSQAAMAEMKALLTQLRPQPLATIGLIEAIREQLEALHFRAEVSTALHHDGFPDEALLLPGTQETVFRVIQEALSNVARHARARHVQVSFGQEMVAGRSWLTVTVADDGRGFDPATSTLGMGMTNMRARIEALGGELAVRSAPHAGTTIQFRIPLAEQESQHEKEVRMREERFQHIFTISGLTSLTGIAFVIGGLSLTLALQNAPLYFAGIGILGVLIGVGLLPVMMNRRRRARPWATHSIWQTLLRFYDLLTVGFLLSIIAWVTFSIKAFALTFLLGVGIVGVAIALIRTHRILNDRITEWATQSTLRTQVRESWFFLGFVIGFQVLVYSGLFGSMQAVYLFHDTLDRSWFVSLLAIGYPLVMIPYSVIGLVISYHHLRRLTALEGKSSVAEPVVDSGLRRLRRTAILLTLAYHILCISVGVLIEFQVPFGGVAALVALVILVGKWWIERSLTARIAEWSSRYSQLSALTMYGTFLFTYIFSFLGLLIGAAIAMSQGGIDASIQDAVIDSSLAALPTAAPWMIVGFGTWWLGVFPYLLLQTINTLRRLQIVAREQADTAQSLSDG
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Miscellaneous:
MISCELLANEOUS: Present with 1500 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
Compared to higher eukaryotes TAF1, yeast TAF1 lacks the C-terminal bromodomains and C-terminal kinase activity. The TFIID interacting proteins BDF1 and BDF2 may substitute for these domains.
Sequence:
MVKQQGSGKTNLANEDEAYEAIFGGEFGSLEIGSYIGGDEGANSKDYTEHLPDAVDFEDEDELADDDDDLPEESDANLHPAMMTMGAYDDVNENGAVLGIDSNSLNMQLPEINGDLSQQFILEDDGGTPATSNALFMGMDANEIHLATETGVLDGSGANEIGHSQLSIGGVNGNDMSINGGFIMEPDMSDGKHKKATKLDLINHEKYLLKKYFPDFEKGKILKWNKLIYRRSVPYHWHSEISRVKKPFMPLNLKFKVQQDDKRLFNSRTISYVAPIYQGKNNLLQSNSSASRRGLIHVSIDELFPIKEQQKKRKIIHDEKTISEDLLIATDDWDQEKIINQGTSSTATLADSSMTPNLKFSGGYKLKSLIEDVAEDWQWDEDMIIDAKLKESKHAELNMNDEKLLLMIEKTNNLAQQKQQLDSSNLILPLNETILQQKFNLSNDDKYQILKKTHQTKVRSTISNLNIQHSQPAINLQSPFYKVAVPRYQLRHFHRENFGSHIRPGTKIVFSKLKARKRKRDKGKDVKESFSTSQDLTIGDTAPVYLMEYSEQTPVALSKFGMANKLINYYRKANEQDTLRPKLPVGETHVLGVQDKSPFWNFGFVEPGHIVPTLYNNMIRAPVFKHDISGTDFLLTKSSGFGISNRFYLRNINHLFTVGQTFPVEEIPGPNSRKVTSMKATRLKMIIYRILNHNHSKAISIDPIAKHFPDQDYGQNRQKVKEFMKYQRDGPEKGLWRLKDDEKLLDNEAVKSLITPEQISQVESMSQGLQFQEDNEAYNFDSKLKSLEENLLPWNITKNFINSTQMRAMIQIHGVGDPTGCGEGFSFLKTSMKGGFVKSGSPSSNNNSSNKKGTNTHSYNVAQQQKAYDEEIAKTWYTHTKSLSISNPFEEMTNPDEINQTNKHVKTDRDDKKILKIVRKKRDENGIIQRQTIFIRDPRVIQGYIKIKEQDKEDVNKLLEEDTSKINNLEELEKQKKLLQLELANLEKSQQRRAARQNSKRNGGATRTENSVDNGSDLAGVTDGKAARNKGKNTTRRCATCGQIGHIRTNKSCPMYSSKDNPASPK
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Sequence:
MNNQYYDCYVEKKEYEKSFWESLGKPKYISAPMVDLSELPFRLLCRKYNCDLTFTPMLHSKNFVEHEKYRKGYFKSCDMDKPVIAQFCGNDSKILLEAINFIKDDVNAVDINLGCPQQIAKKGNYGAFLLHKHDEVVNLISDITNNCVIPITCKIRKIDNDYQKTLNLCYDLQSRGIKMITVHGRTKEEKGINIKQCDYEIIRIIKERLNIPIIANGSIEHFEDIKKCLNYTKADAVMCAEILLEKPYFFSNKNIDAVNIVNEYFELYLKYESNTKYLKGHLFKFLYKYFQVHTDLRDLLNNCHTLNDYINFKNVLNERKNMGTLTETSYSWYRRYRKDI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MAAPPAAQIVSPFPTPPAYYQFYTSDNIANARVPLPPCAHADFTVFGEDYHLNDEIIRPLSEAGIRQLYVNKKDWKTEMKKLNSSAVAAFVDLVSILISCPDSQDRVDKLNDIRDIFINMHHLINEFRPIQARDTLRMMQQKQLDELERTVNDFKDFLVEAKKAFRQSLKVDEVVRLPIPAYRPDLEGPVEEPKRKEETKKREIELAMIGLSVGGERKQQAATSSSTPRPEQQQRLLQKRAMDHAAWSAIFGETMEE
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MTVKVNEKKTLLQYVLDNTSNEVPLLPSLKEYMETVLVYQSIKRPLPAIRPQESFDEFMKELVTRLVMEKSNNVIAYGYKTSAMESRSIFTTFHSSGNFILTHITSHNWSTIFSLLGPKKFLELLVNNKGFVSKVNGESVQIFGDVNSHRKAVVVSKYITKFNVLYNSYSRDFSRFEMIRPSIQTILQDILSFSGLNPGRSSKRYRGFKSLLSRIIANDKKCRYDILYAKFIGTSKCNFANVVSNKTEISQVIQFVLLVLGKLLPLDAWGGVSNKKIIKDRVVDFLLLGANEKIHMDDLFRGIRLKDFKWLGRAHQISSKQDFELRTAFLKGYLWWLFEHLLKNILRSFWYITETSSIVSLELNYFPQYLWKELYESWVSKYAKNNLVKMPSKIQREQLPCGKIKLIPKRSSFRVICVPIKRSLKLLNKKLELDTLEKEKREFERYRKEVLSPVGQILRLKLSKLRDTYESYRASVHSSSDVAEKISDYRDSLLTRFGEIPKLFILKFDMKECYDRLSQPVLMKKLEELFENQDNKTSYYVRYYAQLDASHKLKKVKTTIDTQYHNLNILSSSRHLSNCKSLVDKTKTIALQKGNILEVCRSQIYDVVGSVKDARGNLHLYKRKRGVFQGFSLSSIFCDILYSAMVHDCFQFLWKSKQDFLFVRLVDDFLLVTPDSNIYDQVHNILSGKILESYGAFVNKDKTVVVNQTTTKPSIDFVGLEVNTTDLSIKRNSGSISLVTTNFRTFKTLVKYLKTFYQLNLEGFLLDCSFGVLENVLENMGSLLRLVLREFKTKFTSIVKYDTFHCYKFIKFLYDISNYTIVKYVETNSDWDGAPELLNCIKQIIVKEFSSFESYSEIVEWVQTLNI
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVARSLGKKDYDNLKSVILNAINITVVIMVVLTFIISIFKKDMITGLLGASQSIYPYAKEYISIVVLGGLFQALTLVICYIMTSLGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKPILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKNLVRVKEVVIKTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQMIIFIPLLFILVGKFDIMGAWIAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGRSVEVGGL
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFYQFALIQMALKYDAKHDPLGAMRAFKTAFADVEENPDWRSRRLIERQRWNPYSMEGGSTCAVAGDNFVVVASDTRMTAGEINVINREVDKIHPLSDNIVLTTAGFHGDALQMRKLLETHLHKYRFDYRSNMTVDLCAELLARNLYYRRFFPYYTGAILAGIDEHGKGAVFSYDPIGCIERLPYSASGAAEPMLVPFLDCQVGHVTLSEGTERPKLTLERATALVRDAFRGCAEREITTGDSIHLVIAEAGKPIRHERRKLRED
The following text describes a protein:
Function:
Dioxygenase that catalyzes DNA N(6)-methyladenine (6 mA) demethylation with a low efficiency.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MNHSEARGSGGHKGYRGRSQASEQWVPVAADDKSLEDSSGNRVRGSQGKGRSRTSWSPRNSYGRGNDEHSPVQAYVNKSNVGFVEKGVQQDRKSLEDGIGSTKQPDDGAAAGDNKAVLQSKSTNVSGGSFVSSECEDKDGAKMYCDLVNRVNDVTLSCQESVSSTVVQKVELSSVEDQKSAPKADGAGNSSNESSTRHFDIFLEKKGIVLKPNLLVLSREKKKAAKGYSGTVIRPGMVLLKNYLSINDQVMIVNKCRRLGLGEGGFYQPGYRDEAKLHLKMMCLGKNWDPETSRYGETRPFDGSTAPRIPAEFNQFVEKAVKESQSLAASNSKQTKGGDEIPFMLPDICIVNFYSSTGRLGLHQDKDESENSIRKGLPVVSFSIGDSAEFLYGDQRDEDKAETLTLESGDVLLFGGRSRKVFHGVRSIRKDTAPKALLQETSLRPGRLNLTFRQY
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin and transcription pause-release checkpoint.
Domain:
The inhibitory loop acts as a regulator of protein phosphatase 2A (PP2A) activity: Asp-628 and Glu-629 residues mimic phosphoserine and phosphothreonine residues and bind to the PP2A catalytic subunit PPP2CA active site to block substrate-binding.
Sequence:
MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPPPAEEGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYNELGHPFGYLKASTALTCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAHRKGFQVLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRKFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPSMQGIPKRRRCASPLLRGRRQSPAVNSHIGGKGPPAPMTQAQPGLIKPLPLHKEATNDSIVDDVVENHVADQLSSDMTPNAMDTEFLTSPPNLLEPSTNHTEALGHEHLGNNDLTVGGFLENHEEPRNKEQSAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
The following text describes a protein:
Function:
NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed 2'cADPR (v-cADPR). Cleaves NADP(+), but does not cyclize the product.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity (Probable). The TIR domain alone is active and produces cADPR (residues 134-267).
Sequence:
MSLEQKKGADIISKILQIQNSIGKTTSPSTLKTKLSEISRKEQENARIQSKLSDLQKKKIDIDNKLLKEKQNLIKEEILERKKLEVLTKKQQKDEIEHQKKLKREIDAIKASTQYITDVSISSYNNTIPETEPEYDLFISHASEDKEDFVRPLAETLQQLGVNVWYDEFTLKVGDSLRQKIDSGLRNSKYGTVVLSTDFIKKDWTNYELDGLVAREMNGHKMILPIWHKITKNDVLDYSPNLADKVALNTSVNSIEEIAHQLADVILNR
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MNTHHLTTSRTNPQFYIFSQLFGNDFDWNNCNWGGIQNVTWKEFWQREGHELLEQKWHKRFPEYKDLIEVVSSEEQGLWQELWEKHASDYSEKFWYIFSCAFENYQHDLAKSFGLDVAENSEDVEEDLQNLSLTNKPIKSKQQRVTEKEEDESYLTANDDPEDCDEEQQLRLLGLPTSFASKADIINYRKERKTQYELSSSDSEDDHDLLTMENNENEALHGVQSGSVKKKKRRQRQIKKLKARMPECMQEDNNKMVKYWVKRFSLFSRFDQGIRLDRESWFSVTPEKIAKQTARRLACDVIVDAFCGCGGNAIQFANTCGRVIAVDIDAEKLAMAKHNAGIYGVAHKIEFIHADFLQFAASTKLRPNVVFLSPPWGGPDYQKQATFDIETGLLPVGASQLMQLSRSLASDVAFFLPRNANMKQVVALSGVGQQCEVEHNYLDTRMVALTAYYGKGIIKGSVGEDE
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MGKYAVVVIGPAGSGKSTLCCTIAEHYATKGRSTHICNFDPAAEELRYSPSIDVRDLISLEDAMEGKGLGPNGGLVFCMEYLLSAGEQWICEQLGDHAEDFIIIDMPGQVEVLSHVPAVPNFVRLLQRVGYNVVVLFLLDALAATVDAGKFVSGCTFALSSMVCFDCPFMTVLTKCDLLPPDVKEGDLEHYCYCNFDHVNLKPLQGRWQEMVRTMASVIHDFNLVSFRPMDITDTAYVSNICQQMDEVLQVVDEAEVNDRDLPGPPGEGDGDIPGEDVMW
The following text describes a protein:
Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subcellular Localization:
Secreted.
Sequence:
MRAAVLLFSLLLATGSQARHFWQSDEPKSPLEQVKDVLTVYMNTVKDTGKDYMTQFETSTMGQDLKITETMTSLKAALDAFYEEINPTFEEIKETIIKETSDLRQEMTKGLEAVKKSIDPHLEEFQKKWAADVENFRQRVGPLTQDLKDSTKQKFDELHQKLSPIGKEIRDRAQGHIETVQEFVKPYHEQIKTSVSQKIQELREKGLPSPADYQTKITEQLKALKEKFSPILEDLKTSADPISQKAKADILNFLEEARKSLSSS
The following text describes a protein:
Function:
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Sequence:
MAEAVGAVTLIAAPARRRWLWSALAAMLGLLTARISALEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPEGTDSAVSFFHYSQGQVYIGDYPPFKDRVTWAGDLDKKDASINIENIQAVHNGTYICDVKNPPDIVVRPGQIRLHVVEIDNLLVFLVWVVVGTVTAVVLGLTLLISLVLVVLYRRKHSKRDYTGCSTSERLSPVKQAPRKCPSDTEGLVKSPPSAGSHQGPVIYAQLDHSGGHHSGKINKSESVVYADIRKD
The following text describes a protein:
Function:
Potassium-proton antiport.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSTQSIFDGDNVVVYSASDPLLLFIVQAIIIIALCRLIHIPLSFLQQPRVIAEIIGGIVLGPTVMGRIPKFLDYIFPTSSMGPLNLVSNLGLVLFLFVIGMEVDLRVLVLNYKVTLLVTVFSIVIPFGAGAGISAGLYKFTTREFEFGKFLLFISTAMSITAFPVLARILSELHLLHKRVGVIVLSAGIGNDVIGWILLALSVTLVNSGSGVRAVYILLLALGWCLFLFIAIKPLVYLLAVKTRSLKDKPSESFICIVLSMVLVSAFFTDIIGIHPIFGGFLVGTIIPHENDLTVKITEKIEDLVNCLFLPLYFASSGLKTNISTLNTGKIWGYTIGTICVAIASKMGSSMLAARILKMPWSDSLVVGSLMSCKGLVELIVLNIGLSTGILNETIFSMFVFMAVITTFVTTPMTKFFLRFTKSEHDDNSIESSEELVQYLPELPTRLSFLINHPLDASAAMIFIQHIYENRDKVSGCLHLPQIIIHSIWTLFVDSRTSNLLRASQVDNKVENEALMGLFETFVKIKKFEYESNALLVSGTGYYNVVLETLKKSSSNILIMPYLKDYKTIENESSSSPLSLSSIRLALGDSFKSLDELIPLIKMARIPVGVFFTRNPHNLSVKKIRPIIRSTEYGSPKNDFEQLEKDKKSFDQVEISVKEKGSTYERSKVVILIYLGTENDLIALELLLKFLYEETSIAYIYTYDEFYKDDYATSLPNVVYTSEVLLSKHNDSAFKVWPKLRKNIRKITKPNGFTTDQHSQTFIPSQTHTKLDLRLSDVTDSVRSRINVVKFGNLNSLLSCLHELIQPATLTPSFETEKSITMFLGCRDKQAVSEKLEVAALSEMKKLGYIESSSEFGMLAGLIPLVLLSNFPLIDFFLGKAPTKMVQGY
The following text describes a protein:
Function:
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MATANSTNADQDAVLDDFEALDPSLRNVVEQKSLKWIFVGGKGGVGKTTCSCSLAIQLAKVRERVLIISTDPAHNISDAFDQKFSKIPTKVNGFENLFAMEIDPNLGMSELPDDFFEDQAEGGALGVGKAMMQELLTAFPGVDEAMSYAEVMRLVKGMNFSAVVFDTAPTGHTLRLLSFPAVVEKGLGKLLRLKSQITPFIQQIGGLLGLGDINADEMSSRLEDTLPIIRQVNEQFRDPDQTTFVCVCIAEFLSLYETERLVQELTKCNIDTHNIVVNQLLFPTQEDQPCRMCAARYKMQCKYLDQIEDLYEDFHITKLPLLNHEVRGIEKVKHFSKHILEPYHAGQPL
The following text describes a protein:
Function:
Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Sequence:
MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFARLGTEKVRLTGGEPSLRRDFTDIIAAVRENDAIRQIAVTTNGYRLERDVASWRDAGLTGINVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVKVNTVLMRDVNHHQLDTFLNWIQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSIGKLHLCLFGEGGVNLRDLLEDDTQQQALEARISAALREKKQTHFLHQNNTGITQNLSYIGG
The following text describes a protein:
Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.
Subcellular Localization:
Cell membrane. Cytoplasm. Nucleus membrane. Nucleus speckle. Nucleus, PML body.
Sequence:
PEGSSQVNSTRTPSNLSEEVDEQGQEETTEIPRLSFQRRAGCRRRGGAAARQSPNTEAGGRDISAGGDARTEATGPGLDGAEEPVGTAGSDGRRSTSAPPRPPPPFSRRAFPPPLPGRVAEVTRHVAEVPPAAVLCCGEERRICKPRSEVLPTRGRCGAETLGEAAVTMSDQAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTI
The following text describes a protein:
Function:
Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate in diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (eft201 and eft202).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSETGIIPKSTDYTDWPADVCKYSQVFEDVLVVGTYMLDESTKLRHGKLVLYDTKEDVLKRVFDMHCDAILDFKWSPHDASVLAVAHSTGHVSFYRHQFRAELMFLRGIKVADSSVLMLSLDFSDSGKELAVSMSNGSVLIIDIDSGVIKNKWKEHDYEAWTCHYSRQDNNLLYSGGDDAALVCYDQRIPNSCIWRDIQVHHSGVVSILSRAPFGPYIATGEYGDFMHTLDTRNIGKPLFSANLGGGVWRLEHMETTENYHKVLGILMHRGAQVLRISNDFSSIDASKRIFKEHESMCYGGDWRHTDGLLATCSFYDKRVCLWEDI
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MAVLCQPDGVMVRLGEDRRLGHVGSNEGVNWSGVLAILKLPIVVEAFKPHVGSSSTSIEQLPVDVVVACSQQLEPKAANKCFICRMKVGLTGFKCRCENTFCGEYWYPEKHECSFDFKGVGCDAIAKANPIAKADKVKRF
The following text describes a protein:
Function:
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
Subcellular Localization:
Secreted.
Sequence:
MTPHSIDRAARPSVWSGLALLLSTAHAIVMPDGVTGKVPSLGWNSWNAYHCDIDESKFLSAAEVIVSSGLLDAGYNYVNIDDCWSMKDGRVDGHIAVNTTRFPDGIDGLAKKVHDLGLKLGIYSTAGTATCAGYPASLGYEDVDAADFADWGVDYLKYDNCNVPSDWQDEYVACAPDAVQTGPNGTCSTALEPNLAPPGYDWSTSKSAERFNAMRNALAKQSREIVLSLCIWGVADVFSWGNETGISWRMSGDISPEWGSVTHIINMNSFKMNSVGFWGHNDADILEVGNGNLTAAETRTHFALWAAMKSPLLIGTDLAQLSQENIELLKNKHLLAFNQDSVYGQPATPYKWGVNPDWTFNYTNPAEYWAGPSSKGHLVLMMNTLDHTVRKEAKWSEIPGLSAGRYEVRDVWTDKSLGCLSSYKTAVAAHDTAVILVGKKCRNW