lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MAKMKQKGKSGAAKNYITRNQAIKKLQVTLADFRRLCILKGIFPRQPKSVRKANKGSTAPTTFFFAKDIAYLQHEPVLQSLREHKTFAKKLSRAIGRREWAAAKNLDESKPTYRLDHIIKERYPTFRDSLKDIDDALSLLTLFANLPATDKVSADVIATCSRLCAEWQLYVMKTKALKKVFLSIKGIYFQAEVHGETITWLVPYLFTQHIPSDIDFRIMYTFLELYQTLLGFVLFKLYTDENLVYPPRFDAAKDEQAAGFGALSLDSASAAVLRGENTSVSAASRDAATAASSSSAVITASGKKVSAKDVKKQIKAISKSGNIVPNADEDGEADDVPSAAVEEEDKFVEQPSKSTEEQESAGHLTTFDEIQAASAASEGAAHGLFTPYVFYISRECPRAVIEFVLRSFGALPGRIGWDMVAGAGSALDEDDARITHHIIDRPVPAGGMKRYAGKRVFVQPQYIVDCANARKLLPAGAYGPGQTLPPHLSPFVDDAEVARRGGYVPEEAREQLGLDADAAAVASDDEEDSDEELEADEDAEEEDEDENEEIKKTTLRPALSALLADPSDSGQAGLLDAAELEAEAAGGEDALEDMRRKHTAALKEPRRRQGVDGAPKRKTEEQEAKEMSKMMMSNRQRKLYEKLSYSSGKRAEETAKLQQKKKALNKKAVKGRR
The following text describes a protein:
Function:
Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan (PG) (By similarity). Also deacetylates N-acetylated PG. Does not deacetylate N-acetylmuramic acid (By similarity). Confers host lysozyme resistance. Critical for virulence and escape from innate immune response of the host. Required for intracellular survival of bacteria in macrophages of the host. Required for successful host colonization. Controls the production of inflammatory mediators in the bone marrow derived macrophages (BMMs) of the infected mouse (By similarity). Suppresses Toll-like receptor 2 (TLR2)-dependent secretion of interleukin 6 (IL-6) and interferon-beta (IFN-beta) in the macrophages of the infected mouse. May decrease accessibility of pattern recognition receptors (PRRs) such as nucleotide-binding oligomerization domain protein (NOD) 1 of the host to the bacterial cell wall components. Protects cells from autolysis induced by lysozyme or by other autolysis-inducing agents (By similarity).
Subcellular Localization:
Cell membrane; Single-pass membrane protein; Extracellular side. Secreted, cell wall.
Sequence:
MKIRWIRLSLVAILIIAVVFIGVIGFQKYQFSKSRNKVIMQMDRLMKDQDGGNFRRLDKKENGVEIISYIPKTTEKKDNEIIQKEIGKATDAEVKKLNRDKETQGIIFYTYQKHRMAEQAISYKAVQSEYVKEGRTKFVLKDKKDICKNIVTDAETGALLTLGEVLIKSNQTKLNLKTAVEEELIKTGDFSLKDVGNLGKIKSLVKWNQTDFEITNSEIILPVKIPGAPEPKKVKVKLADIASSVNKRYLPSSVKVPEVPKAKTNKRIALTFDDGPSSSVTPGVLDTLKRHNVKATFFVLGSSVIQNPGLVKRELEEGHQVGSHSWDHPQLTKQSTQEVYNQILKTQKAVFDQTGYFPTTMRPPYGAVNKQVAEEIGLPIIQWSVDTEDWKYRNAGIVTKKVLAGATDGAIVLMHDIHKTTAASLDTTLTKLKSQGYEFVTIDELYGEKLQIGKQYFDKTDSRMVK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 350 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MIGRGVCCRSFHTAGSAWKQFGFPKTQVTTIYNKTKSASNYKGYLKHRDAPGMYYQPSESIATGSVNSETIPRSFMAASDPRRGLDMPVQSTKAKQCPNVLVGKSTVNGKTYHLGPQEIDEIRKLRLDNPQKYTRKFLAAKYGISPLFVSMVSKPSEQHVQIMESRLQEIQSRWKEKRRIAREDRKRRKLLWYQA
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MAVFPIGSHFAPPHQLTKRHVIATSSPISISTRLPQNVSFSKVSGVTGSTRLSKHGVLVRAEDKIRSSSSPSSLDEPIDEDLMDSSGLCDPLCSVDEPSSSYFEANYQPKTDIIKALAILAAALTGTAAINHSWVAANQDVAMALLFGIGYAGIIFEESLAFNKSGIGLLMAVSLWVVRSIGAPSTEIAVLDLQHATAEVSEIVFFLLGAMTIVEIVDAHQGFKLVTDNITTRKPKTLLWVVGFVTFFLSSILDNLTSTIVMVSLIRKLVPQSEYRKLLGGVVVIAANAGGAWTPIGDVTTTMLWIHGQISTLPTMKDLFLPSVVSLAVPLALMSLTSEVNGKEQDPKDVLASEKMAPRGKLVFGVGLGALVFVPVFKALTGLPPYMGILLGLGVLWILTDAIHYGESERQKLKVPQALSRIDTQGALFFLGILLSVSSLEAAGILREIANYLDANIPNVELIASAIGVVSAIIDNVPLVAATMGMYDLTSFPQDSEFWQLIAFCAGTGGSMLVIGSAAGVAFMGMEKVDFFWYFRKVSGFAFAGYAAGIAAYLAVHNLHFEIPTTVAQIPFLTGS
The following text describes a protein:
Function:
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the vegfa core promoter and prevents myc binding and transcriptional activation by myc. Thereby inhibits the production of vegfa and sprouting angiogenesis mediated by vegfa.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus.
Domain:
Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Sequence:
MVLDLDLFRTDKGGDPEIIRETQRKRFKDVSLVDKLVQADTEWRKCRFTADNLNKAKNLCSKSIGEKMKKKEPVGDDDTLPEEAQNLEALTAETLSPLTVTQIKKVRVLVDEAVQKTDSDRLKLEAERFEYLREIGNLLHPSVPISNDEDADNKVERTWGDCTVQKKYSHVDLVVMVDGYEGEKGAIVAGSRGYFLKGPLVFLEQALINYALRILYSKNYNLLYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNTVDEKYLIATSEQPIAAFLRDEWLKPEELPIRYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYASPHDGKSWEMFDEMIGTAESFYQTLGIPYRIVNIVSGALNHAASKKLDLEAWFPGSQAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKAEFVHMLNATMCATTRVICAILENFQTEEGIIVPEPLKAFMPPGLTEIIKFVKPAPIDQETTKKQKKQQEGGKKKKHQGGDADLENKVENMSVNDS
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Subcellular Localization:
Mitochondrion membrane.
Sequence:
MLSRIQNYTSGLVSKANLLSSKALYYGKVGAEISKQIYLKEGLQPPTVAQFKSVYSNLYKQSLNFALKPTEVLSCLKNIQKNELLKYGAYGIQLIGFYSVGEIIGRRKLVGYKHH
The following text describes a protein:
Function:
Guanylate cyclase involved in the production of the second messenger cGMP. Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps; Isoforms c: Regulates sensory integration of conflicting sensory cues in AIA interneurons; [Isoform d]: Regulates sensory integration of conflicting sensory cues in AIA interneurons.
Subcellular Localization:
[Isoform c]: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, axon. Perikaryon. Note=Excluded from the neuronal sensory cilia; [Isoform d]: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, axon. Perikaryon. Note=Enriched in the axon of AWC sensory neurons. Is excluded from the neuronal sensory cilia.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MLRWLTLLSCILLTALHGNIVEDVGAAQQASYPPPPPPFPFNVIVILPKRESTYDNFGMTLQKAMPVIDIAVQEVIKAKKLPPGWINLTYWDSRLYEDILLAERHATVGVIQAYCEHRLDAILGFADNYGLATVTKVTAGLNGGIPILTTSGMPSLLNSKKEYPFLTRMQGSYRLLADSMYQLIAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEKSKTFKREWALNTPQFPFDEDLVIERETFKQWLREISLQSNVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLHWVGGKPPTDLPICGYDKSKCPGYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQKKNEKKKAKKRKNHNDYLPESDPLLRSTSRSSVNSDKFDEDSLIPIRFRLRSSSSGTTRKISAMIDRKLSIFTRKKSTPPSESQKNGGLTPNSLQKAENGDCSPINEVQFRLPLNDRRVSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKDVEIPDFGEEFA
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MENLTKQTHICMKTICCFVLISLLLLSIRVKGNSEEFSYDPCSEKGPKFWGELNIEWAKCGNGSIQSPIALSKWTADLTRGLGDLRRNYRPANAILRNDGHEIIVSIYILFLTYYVGFVYFFFILFNQFRSKIVFSSFTFNSMYPLELHMVHFNNVTQKTAVVGVLFEYGPRDPFIYMIERDIKYINIDGGEEFLGKVDPRVARLDGRKYFRYIGSLTTPPCTEGVIWTVMETVQTVAPYQVKLLQQALVEEKNARPLQKINGRDVFYFDPFSWQSVAAE
The following text describes a protein:
Function:
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate neutral lipid accumulation and participate in the regulation of lipid turnover in vegetative cells. May possess additional triacylglycerol lipase and phospholipase A2 activities in vitro (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MRRAAAAAVTVTTTTRMAAEGMSTAAAAAEATATAAPAAGSRWGRAWPSALRWIPTSTDRIIAAEKRLLSIVKTGYVQEQVNIGSSPPGSKVRWFRSSSDEPRFINTVTFDSEENAPTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTCKSTEETEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAAKYALQHPEHVQHLILVGPAGFSSETEHSSEWLTKFRATWKGMLVNHLWESNFTPQRIVRGLGPWGPGLVQRYTSARFGSHSTGELLTEQESTLLTDYIYHTLAAKASGELCLKHIFSFGAFVRKPLLQSASDWKVPTTFIYGQQDWMNYQGAQQARKEMKVPCEIIRVPQGGHFVFIDNPSGFHSAVFHACRKFLSGDGEEGLSLPEGLTSA
The following text describes a protein:
Function:
Adipocyte-secreted protein (adipokine) that acts as a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis at least in part through activation of protein kinase A (PKA).
Subcellular Localization:
Secreted.
Sequence:
MAAANKGNKPRVRSIRFAAGHDAEGSHSHVHFDEKLHDSVVMVTQESDSSFLVKVGFLKILHRYEITFTLPPVHRLSKDVREAPVPSLHLKLLSVVPVPEGYSVKCEYSAHKEGVLKEEILLACEGGTGTCVRVTVQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSDAAVDTSSKIATKDLKKKEAVEEAENGRDTPANGKANEENGEQEADNEVDEEEEEGDGEEEDGDEDEEAESRAAEDDENDDAYTKKQKTNEGD
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MIVSIAGKLVQVGEISVIIQAAPFDYEVYVGDYTRRQLQNQIGNEVRLHTLDYIEGNAQGGRLTPRLIGFSTLPERQFFDLFCSVDGVGVKKALRAMVRPVKELAVLIEEQDAKTLSALPGIGPATSEKVIAKLRRKMPRFALMVAGGEVADAMEVESPIVSDTYDALVTLGHSESDARKLIDETLATGKKFKDTESLLTAIYQRSK
The following text describes a protein:
Function:
Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKEVIFAENAPKPIGPYSQAIKAGNFLFIAGQIPIDPKTGEIVKGDIKAQTRQVLENIKAILEAAGYSLTDVVKVTVYLKDMNDFAKMNEVYAEYFGESKPARAAVEVSRLPKDVLIEIEAIAYKE
The following text describes a protein:
Function:
Involved in auxin transport. Regulator of the auxin signaling pathway.
Subcellular Localization:
Cell membrane.
Sequence:
MSMKGISSAESDKLSRRISLTHKRNSEELDVFEAAVYFGYNEASSGDHGHTQKYGYNAAREENPRRWGILGGGRRISLDLPIRCSEQVYHLQQDHHEKHEVTTIKERLGNVRHKQPSSPGGKIASFLNSLFHQAGSKKNKSKSKSKTKPTDPEVEEEIPGGGWMRRRRRSSISHFFSSSRSTSTTTTTTASSSSKSLISSSSSGFRTPPPYLNTPTKNYKQFLNYTSATKQVGEEETKTNKEYSWLDEKLKVMESLSENQRIWSDDEDIDDDRRIKREGEDDGMESDSSSDLFELQNYELSRGGLPVYETTNVANINKTHI
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MGRREAPSRAEQRRRRRRRVGGGEAGDGGGGGWARLRERTGLNRAAGEWREQLPPRPPPRPPVRRPVGPEAAAPLGPVRPVWAAPPGSRLGGAAAGRSVRPSPGRPRFQTRGPGARSGRPAAGMGGERQHYYGKHGTPQKYDPTFKGPIYHRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNANKPFLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNAQKSQDFEYYKQFCVPGFQNNKGVAEVLRDGDCPAVLIPSKPLARRCFPAIHAHKGVLMVGNETTYEDGHGFRKNITELVEGAKKANGVLEARQLAMRIFEDYTVSWYWIVLGLVIAMLMSLLFIVLLRFLAGIMVWVMIIMVILVLGYGTCQFAGKTCNPETFASSNESRLCPGAHCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALHKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVMLEYLDQRLKGKAHQWLALFLMTCLKCCFWCLEKFIRFLNRNAYIMIASIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPTLVSFNYLHWVVTSYWYWTLFWGGLGGGGSRAEGGGGVGVFPPGVSFFLSIT
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
Sequence:
MNNSQYYIRVSTACPVTNVADIDFNIDNIKKCIDICIEKKSKLIVFPELCITSYTCGELFSQSLLISKALDGIHNICKYSIDKDVLIAIGSPLLYKNSLYNCAVVIFGGKILGIVPKSYLPNYSEFYEKRWFTEGYKIKSERINLPFQENIPFGVNLIFSDKIFKFAFEVCEDLWVTIPPSSYLALMGANIIGNLSASNEIVSKSDYRRNLVASQSGRCLASYVYSSSGVYESSTDLVFSGHLLIGENGSILKENKRFQRENEVITSIIDIDKINSERLKNVSFTDNSMNMNLELEEITFQFAINDVGDFDRPIDRYPFVPSNEEKRAVRCKEIFNIQTSALAKRLDHTNMKKAVIGISGGLDSTLALLVIAKTFDKLNIPRENIITITMPGFGTTDRTYNNAVSLCKHLNTTLKEINIVDAALQHFKDIGHDKDIHDVTYENVQARERTQILMDIANKEGGLVIGTGDLSELALGWCTYNGDHMSMYSVNCSIPKTLVRYLVRYVAENEVAKEISEILIDILDTPVSPELLPKDKEGNIVQKTEDIVGPYELHDFFLYYFIRQGATPDKIKQLAKIAFKDSYDKETIDKWFSYFIRRFFTQQFKRSAVPDGPKVGTISLSPRGDWRMPSDASFNLWK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Subcellular Localization:
Nucleus.
Sequence:
MEDKRNAESASLGASSGGDSKRARVAARPVSLEDVAEFQKEAIFRAMETYRREKETLEKQLETQGEKERELEERVVRLGTWWDKVADRLALVVGKYEFEKSKVKTEDVKKEEDTERDAGDEDEVEVAPGPTGLATDLELEEKSASISSHFSTLLDLIGDKISKQDKTEVSRLSAGYTDMAEQRHLLVRKIQDLEHEAQTMKNQYLAAAKKLDRYKSPTVKLIEGEDVEEKAEENGDQKTAQMEEKKETEDSPDTKDTGDTKALRETIQVQEEQMKELDAKIAALEHEASLFNAKMADLSESDLLDHSGAFKAAKEQLSDKTGQILALEKSRDAISAEKMALDENRQQYRSTIKREFEKRESELRSQLSRAETDLVRIRTARDEILADLSQKKATEADKLKTIESLKELGEVYKLRIGTLESEVQRWRKEGNEGVNMSSNVEGKSLEELKKEVTVLTLTNQSLMAEIPGMEAAFVSAQKMAENKALDVADRESRLTKLLAEKAKADEKYFAAMRHKDALGAENAKLKAQMVKSSELVNQLQEVDAKTRAKIDVLEKTLSEYVSLHAKQQEAAKRLTSQVAEKTHMLNGAQKYLTTLKEEMKQQGTKLSVGEHRARKLALDNAKLTKQIELSSFGGSSDEIDELRSIAMCSLCSKNWKDTALKVCGHVFCHQCAQDRLDARLRKCPNCNKPFSQNDLLTVHL
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MESRMSKHLHRAVQDLRTDLVEQFGVVEQMINMSVRALVERRPDMAVQVIETDDKVDAKDIRIEEECLKLLALYQPVAIDLRWMVSAIKLNGDLERMADLACNIAERSKSLDLFPLFKVPDDINQMVTITLEMVRSALDSFIEQDANLAREVIARDDEVDRLNVELIEELQSMMKTDTDWIEPAVHCFSATRHIERIADMATNVAEETIYMVSGDIVRHKHHLEEGKAH
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MFTAKNPFEDIVLKATSDELTSENWELNLEVCDKVSSGGDTAARNCIAAIQKRLVHRNANVQLYALTLADAVAKNCGLAAHQEIASRSFTQTLARICLDRNTHSTVKKRCSALVKEWAGEFDDQSLGLMKETYESLKSQDAVAEDETPAEPPREPTSEQLRAEDEELRRALELSIQDQGGRNAWPSYNTEQAETSGSSAPAAASSSSSAYQPTSQSLAPAQQQQQQQHDANHTNGTSSSAHAQPLSAATPPAVASRVRALYDFSPTEPGELAFSRGEVIRVLDSVYEHWWRGEVRGEAGIFPVNYVEVLPDPTPDELQREAQMEARIFSQAADIDRLLSKLRSLDPARDNLADDDELQELYQKSLAMRPKIVKLIDRYSNKITELKAMNDKFVHARGSFDEMMEQSLSRYNPGGHSSQDYLRPRPELQQHFSASSADYAQHPSYPTAHAYSVQQAQSASSAHDQIQYPFNPEQRHGYAQSAGAEPADPSYVQGSRLPSGPQPPQQITMAHQQQPHEQQYSSAPHDDEKRRLFERARAESEAFQQQHFQSQAHTSRSGYSGAYPSQPDASVLNQQMGNMNIGGSSSYASHPTGH
The following text describes a protein:
Function:
Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Subcellular Localization:
Secreted.
Sequence:
MPFNMLTLTGHQCLDIVFAISLLCWAECSPTQQKEMAPTEVQFQSLDFRNVLHWKHQHKATKNLKYFVQHKIHGDKEWSNSKHCQGIRTLQCDLTQETSDPREWYYARVRSLSPEGFSSWAISHRFYPQWETNFSPPQIKVTVAGGQTIKVQIKPPRTPLRGHNGNRIRVTKLHKLTFRIFLMHNDVEEEVHETDSCSKELVIEALRPKTTYCLQALSVTPRSGRISSRSPRTCITTH
The following text describes a protein:
Function:
Involved in a late stage of cell wall 1,6-beta-glucan synthesis and assembly. Has a structural, rather than enzymic, function within cell wall 1,6-beta-glucan assembly and architecture, possibly by being involved in covalently cross-linking 1,6-beta-glucans to other cell wall components such as 1,3-beta-glucan, chitin and certain mannoproteins. Acts as the plasma membrane receptor for the yeast K1 viral toxin.
Miscellaneous:
MISCELLANEOUS: Present with 623 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Identified as GPI-anchored plasma membrane protein (GPI-PMP) as well as component of the cell wall. Concentrated at the surface of mother cells.
Sequence:
MMRRTLLHSFATLLLSLSLWSAAVMAAVTTQVTVVTNVAGALVTETTIWDPATAAAAATTTAQTGFFTTVFTTTNDVGTTVTLTQTVNRATMLPTTTTSTSSTGKTTTTVPTATSSLSSGLYLSTVTTTNDLGTTVTLTQTFTHSSTSATSSASSSVSSSVSSSGSSSSVKTTTSTGSAVAETGTRPDPSTDFTEPPVSAVTSLSIDSYITITEGTTSTYTTTRAPTSMWVTVVRQGNTITVQTTFVQRFSSQYVTVASPSVGSIGMGTLTGTVGVIKSAIKKTVSHNEAQHLGMSSFTSILGGLLTVLIWFL
The following text describes a protein:
Function:
Antimicrobial peptide with activity against Gram-positive bacteria (B.subtilis, S.aureus and L.monocytogenes) and Gram-negative bacteria (E.coli and P.aeruginosa) (MIC=1.3-35 uM). Also active against fungus C.albicans (MIC=6.3 uM). Has little hemolytic activity. Acts by disrupting membranes and bacterial cell wall structures. Binds to peptidoglycan and lipopolysaccharide (LPS). In the context of inflammation and cancer tests, is weakly cytotoxic to normal cells, induces calcium signaling but does not impact cAMP production. In addition, prevents LPS-induced nitric oxid (NO) synthesis but does not affect the IP3 signaling and pro-inflammatory activation of endothelial cells. Does not show significant antiproliferative activity on the breast cancer cell line MDA-MB-231.
Subcellular Localization:
Secreted. Target cell membrane. Note=Adopts an alpha-helical structure in a membrane mimic environment.
Sequence:
GFGMALKLLKKVL
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSVSSSKQPGNDANDANSSVKGVSHLIIVQIIAKLLTFVLNQLIIRYLSPSIIGVTTYLEFICSTILFFSRESIRLSVQRVRNNSDNKDYVAQKVVNFGILAIAFAFPIFMVIGYWQLNYSSVMDKLFVSPFYKPVIVLFVASVILELLVEPIYCLYQFQLDFGKRSKFEGSAIFVKCIVSVLSILLARQYFVDQKFEGVAICAFALAQFSYSLTLFACYLMSFRFEFQNNKINYNLVKLKDENAREFYFEQDTLTIVKGFFVQMIFKQFLTEGDKLLISHLCTIEEQGMYAVMANYGSIIARLLFQPLEESTRLMFTKLLNENTRSQGDEKPQKSESHKCMQTFNYLKLISIFYFNLSLIILFAGVTSGPYLLKLLMGGRASNWESTDIFKLFPQYVVYLPFLAFNGILEALFSSMATNSDLKNFSKFMTLITILVLIFSYLLIDVLNLRISGLILANVFNMSSRIGYCYFKISKFYSKENVKVSFVDIVRYSCPSILITSIIWIIQLFIIGKNTTNFVQLILNACFSFVLVIILMVMERKNSKKPFEKVTNKFMKPKLD
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MATNEEIKKEFSRSGFALAEEDEILQRCVTLCINYSLKPSELVSSWELYHLNRQSIDQTVKNEEMDGFLLHLQNQQKESIMKEEAGLHIYSNRDVDMLLDGIPEDTEDEIVTTPTSKSQRLLLDPFDSISKSRDYGYSTGKSVGHVTPFGQRGQKFVVRFNIGDAAAQAEDGDNNDVENSEDDMIVKKVQTRRRCSLKVNGLGPEPGCRFMYYRTEDRFDSLEKRIVRHADAFAASGLYEEQVDPAVASQRSIFSVGMICCDGEGVLNDKSILLQSSAERTSGQRVPLDLNRLNQFSIFPGQIVGIEGQNPSGHYFTASKLLDTVPLTLTADVDLPPAKKQNLDQEVLTLAEESRETSEVSFIIASGPFTTLDNLLFEPLSELLAHAKRKPPQLLLLLGPFVDSNHPEIEKGAVDGTFSEIFQVEVIRRVQEYVEFMGSEVRVVLVPSLRDANHDFVFPQPPFDIHIPDLEHQITSLSNPGTFEANKVKVGCCTVDVLKQLSVEEMSRNPCGVPTDRLGRLASHLLRQRSFYPLYPPPESLPYDSRLAPQALQISSIPDILLLPSDMKYFVKVLSIGEGEDAAKCVCVNPGRLAKGEGAGTFVELTYKGDPESMHASVISI
The following text describes a protein:
Function:
Enhances the ribosomal termination-reinitiation event leading to the translation of major open reading frames on the polycistronic viral RNAs.
Subcellular Localization:
Host cytoplasm.
Sequence:
MENIEKLLMQEKILMLELDLVRAKISLARANGSSQQGDLPLHRETPVKEEAVHSALATFTPTQVKAIPEQTAPGKESTNPLMANILPKDMNPVQTGIRLAVPEDFLRPHQGIPIPQKSELNSTVAPLRAESGIQHPHINYYVVYNGPHAGIYDDWGCTKAATNGVPGVAHKKFATITEARAAADAYTTSQQTDRLNFIPKGEAQLKPKSFAKALTSPPKQKAHWLTLGTKRPSSDPAPKEISFAPEITMDDFLYLYDLGRKFEGEGDDTMFTTDNEKVSLFNFRKNADPQMVREAYAAGLIKTIYPSNNLQEIKYLPKKVKDAVKRFRTNCIKNTEKDIFLKIRSTIPVWTIQGLLHKPRQVIEIGVSKKVVPTESKAMESKIQIEDLTELAVKTGEQFIQSLLRLNDKKKIFVNMVEHDTLVYSKNVKDTVSEDQRAIETFQQRVISGNLLGFHCPAICHFIERTVEKEGGSYKCHHCDKGKAIIQDASADSGPKDGPPPTRSIVEKEDVPTTSSKQVD
The following text describes a protein:
Function:
Probable transcription factor. Required for smooth muscle (visceral mesoderm) differentiation during gut development. Also required for normal proliferation of the lateral plate mesoderm. Acts as a downstream mediator of bmp4-signaling.
Subcellular Localization:
Nucleus.
Sequence:
MTAEIQQPPSQPPAQSSPMSAATDKHGGQPSAMESASCATKTKKTNAGIRRPEKPPYSYIALIVMAIQSSPTKRLTLSEIYQFLQSRFPFFRGSYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYSMMNGLGFNHIPDTYSFQGASGTISCPPNSLSLDSGIGMMNGHLPSNVDGMGLSGHSVSHLTANGAHSYMGSCTGASGGDYSHHDSGSPLLGGGVMDPHSVYSSPASAWAPSASTPYIKQQPLSPCNTAANPLSSSLSSHSLDQSYLHQNSHNTASELQGIPRYHSQSPSMNDRKEFVFSFNAMASSSMHSGSGSYYHQQVGYQDIKPCVM