lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
Sequence:
MTTTTPPVTLDDVRSAAARIKGVAHRTPVLRSRTLDALVGAEVHLKCENQQRVGAFKFRGAYNAASRLTPEQLARGIAAYSSGNHAQAVALAARELGTTAVIVMPEDAPPSKRDATAGYGAEIVTYDRYTGDRVAVAEALAADRGLTLIPPYEHPHVIAGQGTAALELVEETGELDALVAPVGGGGLIAGSATAVKALHPGMRVIGVEPEAGDDTRRSLAAGRRVSVPVPRTIADGQALPTPGELTFSLNRRLLDGIVLVSDDEIRDAMRFAFERLKTVLEPSGATPLAALLNGRIDALPRRVGVILSGGNVDAARFAELCGAPR
The following text describes a protein:
Function:
Together with the closely related MLP1, involved in the structural and functional organization of perinuclear chromatin. MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery. Has a role in the localization of Esc1 to nucleolar regions. Together with MLP1, mediates tethering of the some telomeres to the nuclear periphery, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing. MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring. Plays a role in the incorporation of components into the spindle pole body. Involved in double-strand break repair, probably also mediated by the YKU70/YKU80 (HDF1/HDF2) heterodimer.
Miscellaneous:
MISCELLANEOUS: Present with 2770 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus, nuclear pore complex. Note=Nuclear periphery, excluded from nuclear envelope adjacent to nucleolus.
Sequence:
MEDKISEFLNVPFESLQGVTYPVLRKLYKKIAKFERSEEEVTKLNVLVDEIKSQYYSRISKLKQLLDESSEQKNTAKEELNGLKDQLNEERSRYRREIDALKKQLHVSHEAMREVNDEKRVKEEYDIWQSRDQGNDSLNDDLNKENKLLRRKLMEMENILQRCKSNAISLQLKYDTSVQEKELMLQSKKLIEEKLSSFSKKTLTEEVTKSSHVENLEEKLYQMQSNYESVFTYNKFLLNQNKQLSQSVEEKVLEMKNLKDTASVEKAEFSKEMTLQKNMNDLLRSQLTSLEKDCSLRAIEKNDDNSCRNPEHTDVIDELIDTKLRLEKSKNECQRLQNIVMDCTKEEEATMTTSAVSPTVGKLFSDIKVLKRQLIKERNQKFQLQNQLEDFILELEHKTPELISFKERTKSLEHELKRSTELLETVSLTKRKQEREITSLRQKINGCEANIHSLVKQRLDLARQVKLLLLNTSAIQETASPLSQDELISLRKILESSNIVNENDSQAIITERLVEFSNVNELQEKNVELLNCIRILADKLENYEGKQDKTLQKVENQTIKEAKDAIIELENINAKMETRINILLRERDSYKLLASTEENKANTNSVTSMEAAREKKIRELEAELSSTKVENSAIIQNLRKELLIYKKSQCKKKTTLEDFENFKGLAKEKERMLEEAIDHLKAELEKQKSWVPSYIHVEKERASTELSQSRIKIKSLEYEISKLKKETASFIPTKESLTRDFEQCCKEKKELQMRLKESEISHNENKMDFSSKEGQYKAKIKELENNLERLRSDLQSKIQEIESIRSCKDSQLKWAQNTIDDTEMKMKSLLTELSNKETTIEKLSSEIENLDKELRKTKFQYKFLDQNSDASTLEPTLRKELEQIQVQLKDANSQIQAYEEIISSNENALIELKNELAKTKENYDAKIELEKKEKWAREEDLSRLRGELGEIRALQPKLKEGALHFVQQSEKLRNEVERIQKMIEKIEKMSTIVQLCKKKEMSQYQSTMKENKDLSELVIRLEKDAADCQAELTKTKSSLYSAQDLLDKHERKWMEEKADYERELISNIEQTESLRVENSVLIEKVDDTAANNGDKDHLKLVSLFSNLRHERNSLETKLTTCKRELAFVKQKNDSLEKTINDLQRTQTLSEKEYQCSAVIIDEFKDITKEVTQVNILKENNAILQKSLKNVTEKNREIYKQLNDRQEEISRLQRDLIQTKEQVSINSNKILVYESEMEQCKQRYQDLSQQQKDAQKKDIEKLTNEISDLKGKLSSAENANADLENKFNRLKKQAHEKLDASKKQQAALTNELNELKAIKDKLEQDLHFENAKVIDLDTKLKAHELQSEDVSRDHEKDTYRTLMEEIESLKKELQIFKTANSSSDAFEKLKVNMEKEKDRIIDERTKEFEKKLQETLNKSTSSEAEYSKDIETLKKEWLKEYEDETLRRIKEAEENLKKRIRLPSEERIQKIISKRKEELEEEFRKKLKENAGSLTFLDNKGSGEDAEEELWNSPSKGNSERPSAVAGFINQKNLKPQEQLKNVKNDVSFNDSQSMVTNKENNIVDSSAAGNKAIPTFSFGKPFFSSNTSSLQSFQNPFTASQSNINTNAPLRTLNIQPEVAVKAAINFSNVTDLTNNSTDGAKITEIGSTSKRPIESGTSSDPDTKKVKESPANDQASNE
The following text describes a protein:
Function:
CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.
Subcellular Localization:
Nucleus.
Sequence:
MSYAAYKMMHWPTGIDHCAAGFITHCPSDAAAFCSAAAASGPEGDVGLVAAARHPKRLGPTPNLVVAAANVLEVYAVRADAAAADGAGGAQPSSSSGAVFDGISGARLELVCHYRLHGNIESMAILSDGAENRRDSIALAFRDAKITCLEFDDAIHGLRTSSMHCFEGPEWQHLKRGRESFAWGPVIKSDPLGRCGAALVYGLQMIILKSAQVGQSLVGEDEPTRALSSAAVRIESSYLIDLRALDTNHVKDFTFVHGYIEPVLVILHEREPTWAGRISSKHHTCMISAFSISMTLKQHPMIWSAANIPHDAYQILSVPPPISGVLVICANSIHYHSQSTSCSLALNNFASQPDGSPEIHKVNFHVELDAAKATWLSNDIVMFSAKTGEMLLLTVVYDGRTVQKLDLMKSKASVISSGVTTIGSSFFFLGSRVGDSLLVQFSCGVPTSVIPDIADERSADIEGDLPFSKRLKRVPSDILQDVTSVEELSFQNNMLPNSLESAQKISYVVRDALVNVGPLKDFSYGLRVNADPNATGNAKQSNYELVCCSGHGKNGALSVLQQSIRPDLITEVELPSCRGIWTVYYKSSRGHTTEDNEYHAYLIISLESRTMVLETGDDLGEVTETVDYYVQGATITAGNLFGRRRVIQVYATGARVLDGSFMTQELNFTALSSESSSSGSEPLGVASASIADPYVLLKMVDGTIQLLVGDHSTCALSINAPSTLTSRGERISACTLYHDRGPEPWLRKTRGDAWLSSGVTVAVDVSGSSSQDQSDIYCIICYESGKLEIFEVPSFRQVFSVGSFFSGESLLVDAFAQGFTEDSAEGRQDETKVSLKKEVANNIRIVELAMHRWSGQFSRPFLFGLLNDGTLLCYQAYCYEGLESNIKGTSLSPDGSVDLGNASDSRLKNLRFHRVSVDITSREDISSLARPRITIFNNVGGYEGLFLSGTRPVWVMVCRQRFRVHPQLCDGPIEAFTVLHNVNCSHGLIYVTSQGFLKICQLPSAYNYDNYWPVQKIPLHGTPHQVTYYAEQSLYPLIVSVPVVRPLNQVLSIMADQEMIHHMDNDASSADDLQKTYTVEEFEVRVLELEKPGGRWETRSTIPMQSFENALTVRIVTLHNTTTKENETLMAIGTAYVQGEDVAARGRVLLFSFTKSENSQNLVTEVYSKESKGAVSAVASLQGHLVIASGPKITLNKWNGSELTAVAFYDAPLHVVSLNIVKNFVLFGDIHKSVYFLSWKEQGSQLTLLAKDFGSLDCFATEFLIDGSTLSLVVSDSDKNLQIFYYAPKMVESWKGQKLLSRAELHVGAHMTKFLRLQMLPAQGLASEKTNRFALLFGTLDGSIGCIAPVDELTFRRLQSLQRKLVDAVSHVCGLNPRSFRQFKSNGKAHRPGPDNIIDFELLTYYEILSLEEQLDMAQQIGTTRAQILSNFSDISLGTSFL
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MRRQFEEPAYKKVPAVNIYEFRELTPLDKLEFPELPKNRKCTNVTMLIVFITFVAGLIGLILSISFNKHLRRWWYGYDSCENLCGFKNVRISFRPEDCKPEDYRDFPVVLYANVTTTCVKLADCKPSDFNLFFGRCFPKDSLPEETIKVQKYFEIISNTWKARYAITVMVFAALGLILLIYGLFRVSAKFTFMALIIVMTSLSAVITIGFWSTYFLKQGRPYLMPSIVSLIYLIPFLVLLHFLRKYFFLMARLYRETVRIIFQAPITLVQPLITILFVFILDAIIIYLLLLLYAVEGKITYSTELKVLNTLFISVVMFWLFAFANGCQCLIVSGVIQAYFFARNKSTLCCPYFFTLWMGLHYHLGTIATGALVITILRILKPLTECFGNRPHTGFCGVVAVCSEWLREMSDYLTRKAYIMTALHGRGIFKSGRRAVRLLWLFLCDTIIIDELACIFMHALSFFIMLCGIILGIVIILPLKVKYIYVPVVLGVCLAGTVTFFYVSVMNVAIETLFLCFCEDRFLNTGNRDNPYFMTPEFYTLMIDALEMAYGGELGHRTYSDN
The following text describes a protein:
Function:
Cell division-promoting factor involved in leaf blade differentiation, inflorescence branching, as well as in carpel and silique shape. Promotes the number of xylem cells. Positively regulates the gibberellin signaling pathway leading to germination, hypocotyl elongation, and leaf expansion. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNTTSSKSKKKQDDQVGTRFLGVRRRPWGRYAAEIRDPTTKERHWLGTFDTAEEAALAYDRAARSMRGTRARTNFVYSDMPPSSSVTSIVSPDDPPPPPPPPAPPSNDPVDYMMMFNQYSSTDSPMLQPHCDQVDSYMFGGSQSSNSYCYSNDSSNELPPLPSDLSNSCYSQPQWTWTGDDYSSEYVHSPMFSRMPPVSDSFPQGFNYFGS
The following text describes a protein:
Function:
Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others; [Isoform 2]: Involved in regulation of myoblast proliferation during myogenesis.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Produced by a back-splicing reaction which joins the 5'-splice site of the first coding exon with the 3'-splice site of the upstream intron resulting in a circular RNA, called circ-ZNF609. The translation starts with the same initiator methionine as that of the linear transcript encoding isoform 1. The stop codon is created upon circularization.
Subcellular Localization:
Nucleus.
Sequence:
MSLSSGACGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDASKPTPGTSLFSPSEGAASKKEVQGRAGDGASAGGLVAAVAPKGSEKAAKASRSVAGSKKEKENSSSKGKKERSEGVGTCSEKDPGVLQPVPLGGRGSQYDGSAGMDTGTVEPLGSIAIEPGAALNPLGTKPEPEEGENECRPLKKVKSEKMESPVSTPAVLPLHLLVPVVNNDISSPCEQIMVRTRSVGVNTCDVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGTLLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPSSNTPVSEAAAASDSKGTSSSSKTRAGANSKGRRGSQNSSEHRPPASSTSEDVKASPSSANKRKSKPLSDMELNSSSEDSKGSKRVRTNSMGSATGPLPGTKVEPTLVDRNCPSPVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEEPALHADLSCNGAPVPQKGSLSPARSATPKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDTDPGALSNDGSDDGPSVMDETSNDAFDSLERKCMEKEKCKKPSSLKSEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAASPGSSSGLTTTVVQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKDSSKELESPLTPGKVCRAEEGKSPFRDAAGDGIKVESLLNGSSESHQSRLASIKAEADKIYSFTDNAPSPSIGGSSRLDSTTPTQPLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDGEGKVDSAKSKDPEQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPGYAQSSPGTLTSSSQAGMEGQPLKTKKDEEPESVEGKVKNDVCEEKKPELSNSSQQPSVIQQRPNMYMQSLYYNQYAYVPPYGYSDQSYHSHLLSTNTAYRQQYEEQQKRQSLEQQQQQQRGLDKKTEMGLKEREASLKEEWKQKPSIPPTLTKAPSLTDLVKSGPGKAKEPGTDPAKSVIIPKLDDSSKLPSQPPEGLKGKLGEASHLGKEASEAKTGTECGRQAEVDPILWYRQETESRMWTYVYPAKYSDIKSEDDRWKEERDRKLKEDRSRSKDSVPKEDGKESTSSDCKLPPSEESRLGSKEPRPSVHVPVSSPLTQHQSYIPYMHGYSYSQSYDPNHPSYRGMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARASPSVSCKASSESKALDILQQHASHYKSKSPTISDKNSQERDRGGCGVVGGGGSCGSVAGAGGTDRSADRPRTSPSQRLMSTHHHHHHLGYSLLPAQYNLPYAAGLSSTAIVASQQGSTPSLYPPPRR
The following text describes a protein:
Function:
Involved in the high-affinity zinc uptake transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MIELLLPGWLAGVLLATAAGPLGSFVVWRRMSYFGDTLAHASLLGVAFGLLLNVNPFYAVIAMTMVLALILVWLERRPQLAVDTLLGIMAHSALSLGLVVVSLMSNVRVDLMAYLFGDLLSVTLSDIWLIAAGVVVVLAVLFWQWRALLSMTISPELAHVDGVNLERVRMLLMLVTALTIGLSMKFVGALIITSLLIIPAAAARRFARTPEQMAGIAVGIGILAVTGGLTFSAFYDTPAGPSVVLCAAAMFVLSLSQKARG
The following text describes a protein:
Function:
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). In association with tfg-1, accumulates at ERES to positively regulate secretory cargo trafficking from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and Golgi apparatus.
Subcellular Localization:
Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Co-localizes with tfg-1 at endoplasmic reticulum exit sites (ERES).
Sequence:
MRRYRIDSMKYEQRMNAGASGFDMSDWNNPYNASPPSSRGGDDDASSVNHSRPRRSRLDNDIPQPRRPILIQPARPVSQKSNRQGTGMSNGSRGLNSTFNGYDRTYSRYHQNSSRGPSEGFSGAPSARNASGYASDYANSRAGVGLLPNNHREPVRPRSTAAERYANASSMRNGFVYDSGESDKTSEELEEDEEEEEVRNFYMEGRAQGSRSVTNTLASEVYNSESESYYYGVVKLGSAIVDHVFRTMPPPEKYYKMPPIDRVAYVFYCAVNNKPYNNIDEFHVIFNREFYSYRGYGDSKDLALFKVCKRMQEEFSLKQLEADRLAYEKARQEAAESEKLDFNQHKIEEREEPKLNISQPEEVLSNGPLHYHSCLQFATIGVGGKLVIIKPAGTIDSITGHVLSTSSVHVDDLKTFLHFDEQSGKVIESVQNFKGPLIAGQTPTHSVRLYIQRQIDALRQIRNAGDVKKSEVVDALLVWQLLEIMVQQHGRVTGPDVATLLTNASEELGEKTGISSNGTSESGSKFEAKERFNKYLLGGHINEAVESAITDGLYADAMTLIRRLHPNDAKKIEEIEARFMNLRSIDDPFATLVAVSSDQPPPILTNSAFDDDNNWKRHAAIVLANLNSQTAMQTIYHLGLLLAKRERNCAADFCLLVVCILAGYDPFIPVAHDGDETSRKHIGLVHSGSNLLNRVDGLSGTAGFSFTDLHATDIFDYALRLGNNNVDSPLAKSIDYQLARIEYAKKLSSFGGFATDAFRYCTEVARSLWMYVAAFDKNAMFDLCDLAESLQYMAAATPDESGWITTMRGMLGAAPVQESQQHVPQPQPVENKSISSEAKKWHDEHQAPLEIGSRNDQQHNDKTVEKPIAPGRASLPPPTLVTESSSESTFTDKSDSSVTVAASASRTSTLTSSTLPPPPSLPKTIEKPISTPPPISKNVVPEMTPPAIVKPPMPTLSMPIPPVSTPIMVSPQPIPIPKPVDASIAKSPRSELDDLWDTSPPSNQTSYPPAPRNIQPSYSPAPNFANPTAPSVPTPPPAVSSAPVLQQATLGQASIPNAKTTAPPVPQKQPELALNERKASKGWFGSIKEKVIKSIPSANQMILPDDSKPSIVWDPVQKRYVGAGVEEEVVAAPPPVMSAPHLMGGGPDSNKSSTNSLRSARSGVGSRYLQSGMATSQAPAMDTGMPPMMPPTMPMSFSFMPAPTEDDSSEYVDPFSGEPTAPSESLSKQNND
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKATGCWVPLVVTVIGQLSCVVGAREPLVNEQEFGALCAMINFSQDLETQQLEESVKDSARHIGAIGLAVGLQSLSEAEDVENVQVGRQGEGGGGGGYWSFWEEAGTKLKGDKTRYIQWVEANFDILRKEKIKEAVENAHTCMKTNNNLWLELKMSPINKSLSDALSGSNKADVMIKQHLEAVEVCGGKGGQPSVWAGKSLIVDLLCICGGSPMPNDRQQACCEGCSTGANEDPWKPVEQSNTRWKHLAQRCKSIGTNEKLSSSSLSRATKVFLEVLKRSTAQKEGTKTFLGAASGEPQHGCTGHTQPGNGKCVQYPTEMVGNENPAVPWLLVLQQAATRIDKLREIEKKLKDILRNVESIKTSKLSQMPRSGISQLKDGTTCNKGRGQKGPSSGVECSECESQAECTHTGCNKREGNCIDIKRPPLASQADKISVPLWLFFLP
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nuclear rim.
Sequence:
MDVWESQHFSALLYLLQCIESNPSNPNVSSRLLIQCLESYSKDFLKFLALDPANANSRKKLESGEVELGGVINKVNEQFIQLSLTLSTQLNLDEIQCASLLQRGIEASQNLDRTPVQAALYFFFLAREQLLECLESLTRVVGLKDLESDISTALKSYLQSLCENGNNLVKTCIDTIPILDNKVSEILKSEAGGQILGVSEVVDFQEFIRLSHEAHVAELETISVILYQLAKVDLFQNSHFESLLVMLRKYDSPNKNAVLILPTLYAFIDKVLEVEYLPDQKVQLRSNSVEILQKIHQAIIQSPSQDWRSSQFKNILGIWWVTRLNATCKQIEKVPSFIDYETTIKNAANEIIQNGVFSDMITLLVYPFRQSETEGMEWAFAFKSRSRITVNWSLIRPFIASIIFSELRSFAQAFVSYMPDILKTLRLLEEDRYLTNTTYPTSIPGEQIEEYFPFEEFYYLLSSIYTYNVSWISDFWDDIESDMYGFLTWSMGSQIPGIITAFTLLLASLCKNTTSASKIYELFSEPIPEVGHLESLMITSPSWSYIFNVFRYYISHLKPVQTVVTSSGLARVHTDPSEIDTDSALILQAYILLFSSVVRQDAQIASTFCENQDLNPIATLFELLECRLPDSVRICIVRALESLAHLSTGSFNNALWTALDNWFVSSVLFDVDGGLAPMSIPAISKRSLTKPVTSCGPLLNNIRRLTVNLEMKISFVNLLTSLTRNKSELNVNLTFPENLGASYRTPGVQPYVDYVVETFVASSTQWRLMRDVGSIRLQYACLQYMLAVLDGLNIDLLLYSRILSSKVRDNLQNNNLHVYLTRHPAISLLEALYTESVYSGLFDLVEYGFDQLEDVSVPKTIVITVSASLCILRNVLSLQRVLFKNVVPYIAELGISKYILDLTISRRAYKEVFMTRISSIVHLALLVGSRHKCFLRSAIEILSYLVDAEGFMNKRNPDENKLLCSIIRTANESKRIIFGFIRTFESQFLTLLSTNDESSLILKLLLNNLKQSGGVYSLALLILGFDISSTNVITLRDQPGYVGSRVSLMNSLLDFIEGRTIVNGIWETPVIMVQALEIVAFLCSCPLTSEVTLSVIRARPGLLVKMVDGEPILTQQVIQNLGGFSSEEVSMVSRCIRSRTQIMNMLATEIHYAASVGQNKYLNEYVASLIRTNEKTHSTELSQKESGFKILEFMDILRIDPQSITFELPNIPGFNLNMFITRFDRGHSDFQFDTERVLKIYRLFFEAEMTSLGGSAEEKYSWLEQQNSKLKELAQRLNTFNAHVVLLQDIHGCLTAWARLTGLLVDDCNEVISDVHFDDFIWEVLRLVLPGVTVHNLGTQGTVSVTSSVIETILPHALRRIGALKPEELGKSTYFMEGIHDVIVGLLKGIQCQQSDESIRENLYGSLLSILTVFQKHTSANGGDKVDPVFKDAFQKLITPNLLTSQFFDVLTKDALYTNGSCWELSVIILNFLHHVSPDISTHLYKYYLRRNFVSSFIDAFSRAFSELLSSNKDVLEVLSGLEAGQCLLITFAQNKLTVHSVLTFDYIKLMVQMLLQLCKQGGIQYLKPPVQRLMIQLLQIFILVLMRVTLKEISNKDKLLLQSIFLLSRKLQDSVQTGADQALSPEMNTVKKYVETISRLLDLYRD
The following text describes a protein:
Function:
Hydrolyzes ribosome-free peptidyl-tRNAs (with 1 or more amino acids incorporated), which drop off the ribosome during protein synthesis, or as a result of ribosome stalling; Catalyzes the release of premature peptidyl moieties from peptidyl-tRNA molecules trapped in stalled 50S ribosomal subunits, and thus maintains levels of free tRNAs and 50S ribosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSNALTNIFYKYVARRNSTWMAGAILGAFVLDSTVSGAVNTFFDSVNKGKLWKDVYAERVKKGISQ
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
Subcellular Localization:
Periplasm.
Sequence:
MKSKNKISHLLLACSLLAASLSAFALTGDTEQPAEVKSDKQTLDMETNTVTFIDNVVIKQGTIEIKADKVVVTRPGGDQSKMIIEGFGNPVTFYQMQDSGKPVKGHGQKLRYEIANDFVVLTGDAYLEQLDSNIKGDRITYLVKKQQMEAFSDKGKRVTTVLLPSQLQDKGPAASGQKKSK
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKKKKVGKERIDKYYKLAKTAGYRARSAFKLIQIAQKFNVFKNANILIDLCAAPGGWLQVAYKNMSKQSTIIGVDLVPIRKIDDNVITIKSDITTSDCIKKIKNIIKMDKADVILNDGAPNVGTTYSYDSFNQNVLVLNSIKIAYIFLKKNGIFITKVFRNEEYISLIWVLEKLFGDVKHIKPRSSREISSEIYLVGLNFLGKKVDKKLFDYTYIFSDQFKKNSNKSSLLETKQESYLDNNENYFSDEESNDEEKVGEKIDKKKKKGLSTILKEKKKKNRQGYDVGDDYRATDICTFIKSDNYVDLLIKNNKFTFDKNYKNNSDPMIKTIYECIYKNECTTKEIFFLCNDLKVLGKSDLYNLIKWRYKIKKSVLNQTSKKNNLDFDNHDVEQTTQELSDVKESSQIDDFNTIVDKNISENELDNTSDEATEKDEKDQVDEIEEFSAYIEKKKKKEQKKKEKKLKKELEKKKKSNRGHQLDFDENEIHFNKDILKLLNKQKFEDHLKILNNDQKDDLEIDHYEDTSSETEKLEHLNQLKNSDLDKLEYLVDLDYEKQKMKEKKLNEEKSNEKLSRRKRAMDFKNEELMKIQKMMELKNEQLLMEKKLREYLSDEDDDEDDDDDDDDDDDDDDKEQEPKQQSDKHGDHQYDNKKSNSDNDVDSLETTQDIFKENKHIKSMVDKIIRLRRSVKNEEEKSNVNHFFDQNIFSNIFSQLDEEDIDAEFDSHIKNKKNVQKKDDSDKDGSISNDDNESIKEIDEHNLPKIPLPDKLAKKEKKKKLKEKYGNNEVKMKNSSFSIVKTDENAQNLNNYFSNLVKDEDELAFIKCIGEKLIHKKSRMDLIDDSFNRYSYMEDESNLPDWFLEEEKKYRRPVIPIDKKILDEYKGKINKITKMPIKKVIEAKMRNRKREITKMKKLEAKIGKIEKNEDDPFLKQKAITNLLKKNKSDKKRDKSYIVCTGKGSKMAKKKKNKKGKTMVKYVDKRLKKDKKAKKRIEKKKKNISRTKYSKSKPFKFRRKI
The following text describes a protein:
Function:
FMRFamide-like neuropeptide. Involved in modulating locomotion quiescence during the sleep-like state called lethargus which occurs during molting between larval and adult stages, acting via the G-protein coupled receptor npr-1. Plays a role in modulating social and feeding behavior; [GLGPRPLRF-amide]: Ligand to G-protein coupled receptor npr-1.
Subcellular Localization:
Secreted.
Sequence:
MRLFILLSCLLAWVLAAPYIDQEDALRVLNAYLEQFGPGSDRVYYVAEDDHGSMKRGLGPRPLRFG
The following text describes a protein:
Function:
NADPH-dependent Fe(3+) reductase. Probably involved in acetate metabolism and not in the reduction of Fe(3+) chelates. Unable to utilize NADH or formate as electron donors. Unlike formate dehydrogenases, contains no W, Mo or Se. Substrates are Fe(3+)-nitrilotriacetate >> Fe(3+)-citrate or Fe(3+)-EDTA > Fe(3+)-oxyhydroxide. Also catalyzes the reduction of NADP(+) with reduced methyl viologen as electron donor. No activity with menadione as electron acceptor. May be alternatively involved in transferring electrons from reduced ferredoxin to NADP(+) and may serve as a major route for NADP regeneration.
Miscellaneous:
MISCELLANEOUS: SfrA lacks the residues that are catalytically important in formate dehydrogenases, including a Cys residue which is a ligand to the heavy-metal atom (Mo or W) of the molybdopterin cofactor.
Subcellular Localization:
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Sequence:
MVSLTIDGKDITVAKETTILDAAALLGITIPTLCWLKKVSPTGACRVCAVEIEGVDRPMTACNTPVKDGIKVTTQSEKLSRIRQKIMELMLVNHPLDCPVCDAGGECDLQNACYGLGAAKQEYGAVLERRKIRYDWPLIESDPNRCILCEKCVKVDHEIVGCNAIRVVNRGEATIIDTVDGNPLNCEFCGNCVAACPTGTLISKPFKFRGRPWAFTTTPSVCPFCATGCQIEYHSRNGRVERVTSDDSTYNSGNLCINGRFGYSYINSPDRLAEPMVKGQKADWNTAMGTAATALKQIVASHGADAVAGFGSPRVTNEDNYLFQKLMRSAIGTGNIDSEARLGFAATQKVLREMLGIAGASTTIDAIDRATAVLVVGCDLNAEATGMEYRVIKAATKNNAKLVLAAMRDIKLKKFANSHLKYRPGNETLLINALTKAVLEEGLENKEFCSANISNLSDLTAALAGVSIADAAAATGVTEADLRAAARLVGGKKGVAVIFGAELMRGGNTDAVKALINLALILGATAGDTGGLFPVYEKTNIRGLLDMGVAPDHFPGHQTDGTTFEKAWGKKLPAAAGKDLWQIIEGIEQGSVKALYLLGCDPVASFPEGERIRKALEKLELLIVQDPFPGEAAKMAHVVFPSSVAAEKNGTFTTIDGRVQPLAKAVAPSGDAREDWDILTELYNRLTGESRIHSPAAVLDEVAALVPAYASVGRTGGTITAQPRSGGLALAPVSARAVAGSPTTLLVGTILYHSGTTTTWSKNNLEIIPKGYIEIHPNDAAKLGIAEGGKVRLSAGSVKVEGTAKITPRVQPGLLFAPSHFRGMNVNALLSRDGGVVPVTVEKA
The following text describes a protein:
Function:
Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3. This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9'. Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development. Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish between the partnerless male X chromosome and asynapsed chromosomes thereby shielding the lone X from inappropriate activation of an apoptotic program. Operates redundantly with set-25 to position chromatin at the nuclear periphery. Required for small-RNA-induced H3K9 methylation. Together with set-25, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9. Together with spr-5, required for transgenerational fertility.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MDQQEPSNNVDTSSILSDDGMETQEQSSFVTATIDLTVDDYDETEIQEILDNGKAEEGTDEDSDLVEGILNANSDVQALLDAPSEQVAQALNSFFGNESEQEAVAAQRRVDAEKTAKDEAELKQQEEAEDLIIEDSIVKTDEEKQAVRRLKINEFLSWFTRLLPEQFKNFEFTNPNYLTESISDSPVVNVDKCKEIVKSFKESESLEGLSQKYELIDEDVLVAAICIGVLDTNNEEDVDFNVLCDDRIDDWSIEKCVTFLDYPNTGLNSKNGPLRFMQFTVTSPASAILMLTLIRLREEGHPCRLDFDSNPTDDLLLNFDQVEFSNNIIDTAVKYWDDQKENGAQDKIGRELNDFFHEIESTSAEFKQHFENAVGSRNEIIQLVNEKIPDFDGTEAAVNESFTSDQRTEIINSRAIMETLKAEMKLAIAEAQKVYDTKTDFEKFFVLTVGDFCLARANPSDDAELTYAIVQDRVDAMTYKVKFIDTSQIRECNIRDLAMTTQGMYDPSLNTFGDVGLRVACRQVISSSQFGKKTIWLTGTAAGRRRAHRSDFLIFFDNGTDAYVSAPTMPGEPGYEVASEKKSVFSLKEMIAKMNAAQIAIMVGQPVGKEGNLDYFLTFHWIRQSHRSAYIRDFMKEFPEWPLLKMPVGMRICLYNSLVDRRKKMVTVIGTDRAFAIVRHEAPNPLAPGNRCTDFPCNDRNHQHIDEKIYRGSHRLEGAAHKKHMISTNNNLSQRRKDQLQSQFEPTDMIRSMPERNHQQVVKKKTTGTNQNVASTNDAKSKREIEIRKKNQFLFNKIIVPIPVLTPLENLKAHAQCGPDCLQKMDADPYEARFHRNSPIHTPLLCGWRRIMYTMSTGKKRGAVKKNIIYFSPCGAALHQISDVSEYIHVTRSLLTIDCFSFDARIDTATYITVDDKYLKVADFSLGTEGIPIPLVNSVDNDEPPSLEYSKRRFQYNDQVDISSVSRDFCSGCSCDGDCSDASKCECQQLSIEAMKRLPHNLQFDGHDELVPHYQNRLLSSKVISGLYECNDQCSCHRKSCYNRVVQNNIKYPMHIFKTAQSGWGVRALTDIPQSTFICTYVGAILTDDLADELRNADQYFADLDLKDTVELEKGREDHETDFGYGGDESDYDDEEGSDGDSGDDVMNKMVKRQDSSESGEETKRLTRQKRKQSKKSGKGGSVEKDDTTPRDSMEKDNIESKDEPVFNWDKYFEPFPLYVIDAKQRGNLGRFLNHSCDPNVHVQHVMYDTHDLRLPWVAFFTRKYVKAGDELTWDYQYTQDQTATTQLTCHCGAENCTGRLLKS