lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
Sequence:
MRGSGPRGAGHRRTQGRGGGDDTPRVPASLAGCYSAPLKGPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDENGRSIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAIFPDTITGADSSQLLEVSGSCVNHSVTDDPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVSVAASNDQSQIPIIAVSVTVGVILLAVMIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMSSLQEMKVQMVNGMVPV
The following text describes a protein:
Function:
Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLLLDLIQQLLEYLNIPVDRLVPIWENYANRQYFLHVLRNHLPLVLPGINLQVLERLENKEYGWTRSVVRVIGTLLPLAPTPRPFFQHVTGPYAVEGKSNGAVSRPGIPSLVDVYCLTDDDVYSYTRFRHHLPGNRCEEMKSLAPSYKRKLSWEPTIINRAPDTSLPPSSENAIQKIAALEGELLQLRAQIAAIVAIQDTKSMQSCSETLSSFGSPTHDLLQPSLTSTPLSGQILQPVTPAPPPPPPPPPPPAPPSKVNTGESAIELIRKRKAVHKKSPKERAMVDNTNNLPSMMDVLKGMKSIQLRAVERSPGGTPLTRKDKKRRSLDDPAAIIANALKQKFAHRLKNDSFDKENISHEESPFSSPEIPQFGRHLLKPVGKQTGAVQEGKQVLVKPGPHV
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MHQVCNHRNESSRFQLEAIDCPSGISRSSRCVRDSQLLGVVLLDWQSTTEDTQSSMASQDQGIYTAAEEFVGAQLDSLPPTFTASSDYDGGIIDDYEEQPTTNVNQTYGVPEFVKNFIRSLYRAFTERRVDEMQILCEAGFIKITERAFSKSAWPDADRIAPLVNNGEGTIDVPTLDQRFESYYNYCNLFNCILSAKAPVRLELPHQWLWNIIDEFIYQFQSFSLYRYKLKHKQENDLAMLRDHPKVWNVHGVLNVLHSLVEKSQINSQLKAYNNGDDPKSVADEFGNCPLYKMLGYFSLIGLLRLHSLLGDYYQAIKVLENVQLNKKSLYAVVPACQVTTYYYVGFAYLMMRRYQIAKKELQMYALLAMAWIMCPCRIDESVLSMLGDKYDKEKFIKLQQGNLQQFEDSFAYACPKFVSPVVPDYDTLSQSQHKAPYQFQLKNFVNEVKQQVAIPIIRSYLKLYTTMPVAKLAAFLDMDEDNFRAQLLSFKHKMSNLVWTKGQRAIDGEFQTSSGVSFFIDEDMIHINDCKVVPRYSEFFLQQIRKYNEVLLLSKNWFIGLKA
The following text describes a protein:
Function:
Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.
Sequence:
MATLLRKIGLIRLHNRDTEDPKHHHNHRGGGQQSASLRGKGGAKSGGHKQQQQLQQQQQPPRGAGDATRDPARARASGAELAPRDKAPALRAARCGGAAAAAGAHRRRAAGARAGPGPAVAAAAAGGSLVPAARQQHCTQVRSRRLMKELQDIARLSDRFISVELVDESLFDWNVKLHQVDKDSVLWQDMKETNTEFILLNLTFPDNFPFSPPFMRVLSPRLENGYVLDGGAICMELLTPRGWSSAYTVEAVMRQFAASLVKGQGRICRKAGKSKKSFSRKEAEATFKSLVKTHEKYGWVTPPVSDG
The following text describes a protein:
Function:
Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.
Sequence:
MIAMQHDIPLESSGPNADAMAEAVSTCIRCGFCLSACPTYDVLQRESDSPRGRIILMKEVLEGAMPADKAAPHLDACLGCLACEPACPSGVSYRHLLSPYRSLVRERTTVAWPQRLQRWLTAQTLPYPKRFRFAARMGMIGKKLSALVPPVLRPMLELLPETLPAAKELQPRYAPMGDQVGRVALLAGCAQQVLAPQINEATIHVLRHIGLEVVVPTQQSCCGSLAWHVGDGDRAAKFARNNVRVFAGDQSSFDAVVTNAAGCGSGMQEYGMILRGTDIESQASDLAGKVKDVSVVVCEHADRLRLKRPALVHEGEAIVRVAYHDACHLANAQGVRVQPRELLRRVPDVELVDVAEAHLCCGSAGTYNLDQPETADELGRRKAKAVMATGAPIVVSGNIGCLTQLQTHLNSMATEAHPAPRVMHTMEFLSACLNESPSPNPILN
The following text describes a protein:
Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
GQPGEVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGPTGPKGDVGARGVSGFPGADGIPGHPGQGGPRGRPGYDGCNGTRGDAGPQGPSGTGGFPGLPGPQGPKGQKGEPYALSKEDRDKYRVSMLFVCLQGPPGRPGPIGQMGPMGAPGRPVILCPPDSKLSLLLNNLQGDVGQPGPNGIPSDITLIGPTPSTYHPDMYKVKRGSFPVNLGRLQRSLAFGWFLEFPPEAGNKTFISVFQGSRGLDGFQGPSGPRGPKGERGELGPPGPPAYSPHPSLAKGARGDPGFQGAHGEPGSRGEPGDPGPVGPPGLSIGDEDSKRGLPGEMGPKGFSGEPGPSAYYPGPPGADGKPGPQGLPGPAGPPGPDGFLFGLKGSEGRVGYPGPSGFPGGRGQKGWKGEAGDCQCGQVIPGLPGLPGPKGFPGVNGEFGKKGDQGDPGLHGIPGFPGFKGAPGIAGAPGPKGVKGDSRTITTKGERGQPGIPGVHGMKGDDGVPGRDGLDGFPGLPGPPGDGIKGPPGDAGLPGTPGTKGFPGEVGPPGQGLPGPKGERGFPGDAGLPGPPGFPGPPGLPGTPGQADCDTGVKRPIGGGQQVVIQPGCVEGPAGSPGQPGPPGPTGAKGIRGIPGFPGASGEQGLKGFPGDPGREGFPGPPGFMGPRGSKGAPGLPGPDGPPGPIGLPGPAGPPGDRGIPGEVLGAQPGARGDAGLPGQPGLKGFPGEIGAPGFRGSQGMPGMPGLKGQPGFPGPSGQPGLSGPPGQHGFPGAPGREGPLGLPGSPGLGGLPGDRGEPGEPGEPGPVGMKGVSGDRGDAGVSGERGHPGSPGFKGMAGMPGIPGQKGDRGSPGMDGFQGMLGLKGRPGFPGIKGEAGFFGVPGLKGLPGEPGVKGNRGDRGPPGPPPLILPGMKDIKGEKGDEGPMGLKGYLGLKGIQGMPGVPGLSGIPGLPGRPGFIKGAKGDIGVPGTPGLPGFPGVSGPPGITGFPGFTGSRGEKGTPGVAGVFGETGPTGDFGDIGDTVDLPGSPGLKGERGVTGIPGLKGLFGEKGAEGDVGFPGITGMAGAQGSPGLKGQTGRIVATAGTGPGEMGLDMLPTSVIPHRAGLLPYVNGAGTNLCCCHFIAGVDAHGDPGFPGPTGDRGDRGEANTLPGPVGAPGQKGEQGIPGERGPVGSPGLQGFPGISPPSNISGLPGDVGAPGIFGLQGYQGPPGPPGPNALPGIKGDEGSSGAAGFPGEKGWVGDPGPQGQPGVHGLPGEKGPKGEQGFMGNTGPSGAVGDRGPKGPKGDQGFPGAPGSMGSPGIPGIPQKIAVQPGTMGPQGRRGLPGALGEMGPQGPPGDPGFRGAPGKAGPQGRGGVSAVPGFRGDQGPMGHQGPIGQEGEPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEEEIKPYISRCSVCEAPAVAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYFANKYSFWLTTIPEQNFQSTPSADTLKAGLIRTHISRCQVCMKNL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MLPSFTNFSRPLRQAAPTVIRSFSGTAAIMGVQKTVISEGSGASPQKGDTVTMEYTGWLRTPGQPEEKGKQFDSTTGRGSFQTPIGVGRVIKGWDEGVVTMKLGEKARLDITSDFAYGSQAFPGLIPPNSDLIFEVELKKIN
The following text describes a protein:
Function:
Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQKSESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSFYEDFCCWI
The following text describes a protein:
Function:
Plays an important role in cell growth. Required to keep the uninucleated state. May be involved in the organization of the cytoskeleton which affects microtubule functions. Most likely RHO3 and RHO4 of S.cerevisiae regulate partially overlapping but different pathways.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MNTLLFKRKGGNCGNESNIVSQGSPSSSNLPESPGTLDEKNLPRLPTPFARSLSTIPSYEQMKRTNKLPDYHLKIVVVGDGAVGKTCLLISYVQGTFPTDYIPTIFENYVTNIEGPNGQIIELALWDTAGQEEYSRLRPLSYTNADVLMVCYSVGSKTSLKNVEDLWFPEVKHFCPSTPIMLVGLKSDLYEADNLSDLVEPSSAESLAKRLGAFAHIQCSARLKENIDEVFETAIHTLLSDSLYAPREPTHTIKNPFKRNTTRSDIDSSTGDTSVSISGTKRLRKNKCIIM
The following text describes a protein:
Function:
Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as a costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MARCGAGRAAALGLVLRLLLGLRTGPEAAPAPTSAPAHTLVQVSGPRAGSCPTDTFKCLTSGYCVPLSWRCDGDRDCSDGSDEEECRIEPCAQNRQCQPQPALPCSCDNISGCSAGSDKNLNCSRSPCQEGELRCILDDVCIPHTWRCDGHPDCPDSSDELSCDTDTETDKIFQEENATTSMSSMIVEKETSFRNVTVASAGHPSRNPNAYGVIAAAGVLSAILVSATILILLRLRGQGYLPPTGLLVAVKESLLLSERKTSLI
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Miscellaneous:
MISCELLANEOUS: Present with 35700 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLSAARLQFAQGSVRRLTVSARDAPTKISTLAVKVHGGSRYATKDGVAHLLNRFNFQNTNTRSALKLVRESELLGGTFKSTLDREYITLKATFLKDDLPYYVNALADVLYKTAFKPHELTESVLPAARYDYAVAEQCPVKSAEDQLYAITFRKGLGNPLLYDGVERVSLQDIKDFADKVYTKENLEVSGENVVEADLKRFVDESLLSTLPAGKSLVSKSEPKFFLGEENRVRFIGDSVAAIGIPVNKASLAQYEVLANYLTSALSELSGLISSAKLDKFTDGGLFTLFVRDQDSAVVSSNIKKIVADLKKGKDLSPAINYTKLKNAVQNESVSSPIELNFDAVKDFKLGKFNYVAVGDVSNLPYLDEL
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Required for efficient pre-rRNA cleavage at sites A0, A1 and A2, and biosynthesis of 18S rRNA.
Miscellaneous:
MISCELLANEOUS: Present with 5130 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The WD domains are required for nucleolar localization and U3 small nucleolar RNAs binding.
Sequence:
MSDVTQQKKRKRSKGEVNPSKPTVDEEITDPSSNEDEQLEVSDEEDALESEEEFEGENPADKRRRLAKQYLENLKSEANDILTDNRNAEEKDLNNLKERTIDEYNNFDAGDLDKDIIASRLKEDVAEQQGRVFRYFGDKLLISEAKQSFTRVGENNLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIANVSGARNGIYSAVIDQTGF
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLKIFLEDGCIYAPTGFFLLGNIDIPFEENCFNLNRLYPRVFQHLGRKNGFTRLCKSRMSLSEDKWSTYCLSSLAAQNICSSRFNIMPHSEHSDLTGSICSTSYCSLVNSLPSRSSIHSIGSSVYAPNRAIFILDLKTMMILVVNDQACELLGYSSNELIGQPFSLIFSKPSTVIEEALSNECGETDGPNVIAFGTVVDIVCSNKEKIPVSIWMKKLEHGPCCVALLEPVERFTVWVTFQSDGKIISCDNLFTQLFGYASLEEVVGREIMDLIPSLQMPPPGQLVSEALKIQKLTGRTKDGNTFPLSLKLRSEALCKEEEEGQPEPSVFIYSASLWIFTTISGLITLLPDGTIYGINHNFALTLFGYEKEEVLGKNITFLIPDFYNYMDLIENSSVPTLNITNPVDRRNENKTGKGREGGKQKWNQADGTEDPGVNILHSANEFQQILEEDKKASGPLRFPSKIEVLGENDGNSSPSSFLPLEEISTPGVDSPPTQEEQPLPMRAPEEEHAETRMVPGQDASGSQKSLTGILKKEHSAQSKGDPKKLNSVVILEQSTFQSKVLDSSSASDPKENTSSVGPAITEGTRDEVHSSEKHLVSETLDPQTTLLPNADEQKRSAGVEDIQGGSAPEDTSVAHTPPGYNINPLADTLGKQTLNAQATSTPMKLGKEQIPRISLQMEILEGTYTGSCYHRDGTKLNIQFELRHVELKGPADLFCCWVVKDFFPSSRQGLAGRTQCLFSSLNASSHSLLEESRMGPSEQFRKQKEVIEEFFQSKDLGVLKAYEGDYSKRYTTVRPIGSGAFGFVWIAKSKEDGTEVVVKFIKKEKVLEDCWVTDPALGKVTQEIAILSQLSHPNIIKVVDVFENEEFFQLVMEKHGSGMDLFSFIDSHPTLDEPLASYIFRQVVAAVTYLRSKNITHRDIKDENIIIGEDFTIKLVDFGSAVYMEPGKYFYTFCGTIEYCSPEVLMGHAYSGPELEMWALGVTLYTLMFEENPFNELDEALEAILNPPFLVSPELLNLLCGLLHPQPEKRLTLDLVIQHTWVTQPVNLANYSWEEVCHVTIESECSI
The following text describes a protein:
Function:
Component of the cuticle of African malaria mosquito.
Domain:
The tetrapeptide (A-A-P-[AV]) repeats found throughout the protein are also present in many proteins constituting the protective envelope of other species.
Sequence:
MAFKFVIFAAVVAVARAGLIASPAVSYAAAPALVAAPVAKVAYAAAPIAKVAYAAQPEEYDANPHYSFSYGISDALTGDSKSQQESRSGDVVQGSYSVVDPDGTKRTVDYTADPHNGFNAVVRREPLAAKTIVAAAPVATKVIAQPAVAYAAPVAKTISYAAPVATKTYVAQPALSYAAPLTKTYVSQPALSYAAPVAKTISYSAPLATKTYVSQPAISYAAPLAKTYVSQPALSYAAPAYAYHH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEYPNPPPPVTSNYQGEPEKIAQATDMMIKRVTDAKKIIEELLQMLDLQEKCPWPLMLEKFSTLASFMSSLQSSVRKSGMPHGHEDYGQFLRSHVLVTQRLQYEPDETLQRATQGRVMSWNHALVPEYLRTKPNPEMENEEGMLDGERSAKSADLVVRQIAAYNKNIEGLINHLNSVDRMHTEAAIEKPTYNRDETAKIVKSILTGEGIRSQRTMAPAPPSSAPMTTAPSSTGPSSSQPISGNQPEYQGSQLRQQLSGGQPQTSQAHLPMYSHHQQPQYSHQQPMNPQHHSPMKFQQ
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
Sequence:
MTTVGIRGTFFDFVDDPWKHIGNEQAAARFHQDGLMVVTDGVIKAFGPYEKIAAAHPGVEITHIKDRIIVPGFIDGHIHLPQTRVLGAYGEQLLPWLQKSIYPEEIKYKDRNYAREGVKRFLDALLAAGTTTCQAFTSSSPVATEELFEEASRRNMRVIAGLTGIDRNAPAEFIDTPENFYRDSKRLIAQYHDKGRNLYAITPRFAFGASPELLKACQRLKHEHPDCWVNTHISENPAECSGVLVEHPDCQDYLGVYEKFDLVGPKFSGGHGVYLSNNEFRRMSKKGAAVVFCPCSNLFLGSGLFRLGRATDPEHRVKMSFGTDVGGGNRFSMISVLDDAYKVGMCNNTLLDGSIDPSRKDLAEAERNKLSPYRGFWSVTLGGAEGLYIDDKLGNFEPGKEADFVALDPNGGQLAQPWHQSLIADGAGPRTVDEAASMLFAVMMVGDDRCVDETWVMGKRLYKKS
The following text describes a protein:
Function:
Chlamydia replicate within an intracellular vacuole, termed an inclusion. IncA is probably involved in the homotypic fusion of inclusions.
Subcellular Localization:
Secreted. Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane; Multi-pass membrane protein. Note=Secreted, probably by a type III secretion system (Probable). Localized in the inclusion membrane (Probable). In the inclusion, the C-terminus faces the host cytosol (By similarity).
Domain:
IncA proteins share the same general organization: a short N-terminal domain, a large bilobed hydrophobic domain, and a C-terminal cytoplasmic domain.
Sequence:
MTTPTLIVTPPSPPAPSYSANRVPQPSLMDKIKKIAAIASLILIGTIGFLALLGHLVGFLIAPQITIVLLALFIISLAGNALYLQKTANLHLYQDLQREVGSLKEINFMLSVLQKEFLHLSKEFATTSKDLSAVSQDFYSCLQGFRDNYKGFESLLDEYKNSTEEMRKLFSQEIIADLKGSVASLREEIRFLTPLAEEVRRLAHNQQSLTVVIEELKTIRDSLRDEIGQLSQLSKTLTSQIALQRKESSDLCSQIRETLSSPRKSASPSTKSS
The following text describes a protein:
Function:
Transcription activator, when associated with BHLH002/EGL3/MYC146, BHLH012/MYC1, or BHLH042/TT8.
Subcellular Localization:
Nucleus.
Sequence:
MEGSSKGLRKGAWTAEEDSLLRQCIGKYGEGKWHQVPLRAGLNRCRKSCRLRWLNYLKPSIKRGKFSSDEVDLLLRLHKLLGNRWSLIAGRLPGRTANDVKNYWNTHLSKKHEPCCKTKIKRINIITPPNTPAQKVDIF
The following text describes a protein:
Function:
Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Nucleus.
Sequence:
MRDPLTDCPYNKVYKNLKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKALQNTRKSCVSSAWAWASEGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQPSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPSNAGNTATKA
The following text describes a protein:
Function:
Involved in RNA processing and negative regulation of glucose repression. Regulates the level of two antigens, P43 and P70. Binds to protein phosphatase type 1. Functions with REG2 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly.
Miscellaneous:
MISCELLANEOUS: Present with 2560 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSTNLANYFAGKKDIENEHVNRNASHESNSKSDVKISGNDNDNDEDMGPSVSMAVQAKNDDDFHKSTFNLKRTRSMGLLDEYIDPTKKLLGRSDDLYDNDNEYYDNSSNNSSSNSSDDDYDDGYQEHSTSVSPPPADNDSYLIPQDDNDVVVEPERHVDYLSHEWKESEISNSWKYIILKKKKRDVDLVNAARLENASWRTWAKARNNLKTVSPEVVNWSKDSDVTWLYGPIVRDSEGNAQSEEEHDLERGYGSDDENSKRISMPTKNSKSIAAAPKPILKKRTVTEIIEDNALWKLNEARKHMTEMKHASVIMDPNGNKNVHDDFDALAAQVNAQYYHYPKESNSSVSLKSQHSDKKDNSTIPNPVGENSNGGGDKGEEDLHLKSALHVQNNRSTAQSNKSILENSTNDRKANLDQNLNSPDNNRFPSSTSSSNRDNENNSMGLSSILTSNPSEKSNKPTKNRHIHFNDRVEQCMALRYPASQSEDDESDDENKQYVDVNNNANVTTINNNRTPLLAIQHKSIPINSATEHLNKNTSDDDTSSQSSSSSHSDDEEHGGLYINARFSRRSDSGVHSPITDNSSVASSTTSRAHVRPIIKLLPDTTLNYGSDEESDNGEFNGYGNAVSHNVNTSRGYDYIYDYNSVYTGDTSSFLPVDSCDIVDVPEGMDLQTAIADDNASNYEFNNAVESKEKHVPQLHKASANNTTRQHGSHMLLYDDDNYSSSSDSEQQFIEDSQYNSSDDEEEEDDDDQEVDDNHDEGLSLRRTLSLGKSGSTNSLYDLAQPSLSSATPQQKNPTNFTGGKTDVDKDAQLAVRPYPLKRNSSSGNFIFNSDSEEESSSEEEQRPLPANSQLVNRSVLKGSVTPANISSQKKKALPKQPKASDSSQSFRIVNNTPSPAEVGASDVAIEGYFSPRNESIKSVVSGGNMMDHQDHSEMDTLAKGFENCHINNASKLKDKKVDSVQTTRKEASLTDSSNESLHKVVQNARGMASKYLHSWKKSDVKPQENGNDSS
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MDRTLQSHEGLSPVNVAGTLHQSERFRAECKELIKETKQICKRMQEDENQQFDQKLRRIQFLKKELELKLDEVNLEIDDLVVLQSRVTKALDACKEPLEVTDLCMKERLKRPNSERFHDEVDGELLKESEGLKRVESLLQRVTEQISEQLRLNRSAKYGIEKDLKEKSEAQNVDNFCTLMATLSMSHRHRPKTHSTPEPSSVLTLDQWENISYANMAKAEQQKTNSRSLQVLVQSVLDQTAADMQKQVQATTTAIQLNVQKMKNAKNQMEDELVKIQSEISSQRKTREDLRVAVAENEEFLSLTQARLALRHERPGKEQWRDPAQRKLLADVQKITEHIKQLQQEVDRSEDEERRLLNWKLRLQESIDSKANCLYIDEVVCMQRREAVIIQNF
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.
Sequence:
MASLVNGHSTQPGEMRNHPEDESEFQLEFTDDIHKTHMLASLNTMRKNRHFCDVILHVGNTEVHAHRAVLASASPYLAELFANDQAQNPLENVVTFKLNGGFNKDALRILVDYAYTGQLDVKYNQVKAVFLAANHLKMDRVTRTCAQHLIKHLSVENCIEIRSLPGIARNKEFIQQVDAFIAKEFDKICKNNDVLNLHCAKIEVLNQSREEMSLVNQNSLCRLVLEWIKRQVGEESISVEMLSDKTFMLYLAIDNSLQDCSSLPTGDISDTEIVQDYKKMSLKNNNTNAKSKRKCLGQPSKPRVLIYNREIGEEIELEGEPDWNLIASEKVGEHSFLALVTLGGRLSTLSIQLRLNTPSTPSPVQTPDSSRPASEEKPDLYCALANMSCPRCSVGCANFLNTLLVCGGYDRTECLRTVEQYIPETNTWKALPSMRENRGRFKIAVVNDKVYAIGGSNGTTELDSVEMLDLSLDKWVKMPKLPLARSNMGVCHLDGLIYCIGGWNGQVGIKQCDVFDPVASEWSSIASLNTGRYQAGVTSYNKLVYAIGGCDAWNCLNSVEVYNPEENTWSGIKPIITARRGCGVAVFNDKLYVVGGSDGSHSLSSTEIFDEKTQTWVVGPIMTTPRANVDVAVVGDRLYAVGGFSGKTFLNTIEYLDAKSNEWTTFVPKGSCEMLRKSRSRHNSRRSMSEKTESVERPSESFES
The following text describes a protein:
Function:
Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVSLLCCGPKLAACGIVISVWGVIMLILLGVFFNVHSAVLIEDVPFTEEDIFEDPNPPAKMYRLYEQVSYNCFIAAAIYIVLGGFSFCQVRLNKRKEYMVR
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MNRWQWIDGRRAAGSGSGSGSGSGSGGVHEILVGGEAINASGSNIRLYDGGQQTSFEDGQVALTPYRIIWWRGAEQWMHLELRHVSHVSHTAATFFGSPKLILHFTQLEHPLPRAVAATSSEAMTKISFRNRDENTVTAFHHGLLAVLAAQMWLTQPIDLNPSCPTPAGGAIHAAGNESNSASTGAVSQAAPVTLTGSGTGGIRRVVKQTETSLAAADSSLQEAFSGDLQGLQSKASELLALAAKLSARVQDEDNAAISQQLEDYLLSIGIDNPVVRDKQRPAVCPRRFPDSLANRFIPDDLTWKCGYRSFIDNWLKNCQRSCPPSWPRFAAFFFYTPVVTLIFVLWRAVAAWPARVDSRSLFSPDHILARLTRYMQHNGVLAVTDLYCLYNRARGTELLSPNDVLHACEQFEPMNLPYQLRVFSSGVKAVEARAANGAGQFDHTAMMDMVQAQGYLTAGRLARLKSISAVVATELLLVAETAGWLARDESTEGLRFYPNYFLHPRTVAASA
The following text describes a protein:
Function:
Involved in multiple sites RNA editing events in chloroplasts. Involved in the editing of the site 9 of ndhB (ndhB-9) and site 1 of ndhG (ndhG-1) transcripts, which are two plastid-encoded subunits of the chloroplast NAD(P)H dehydrogenase (NDH) complex. Not essential for the activity of the NDH complex of the photosynthetic electron transport chain.
Miscellaneous:
MISCELLANEOUS: The DYW motif is dispensable for editing activity in vivo.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MMLSCSPLTVPSSSYPFHFLPSSSDPPYDSIRNHPSLSLLHNCKTLQSLRIIHAQMIKIGLHNTNYALSKLIEFCILSPHFEGLPYAISVFKTIQEPNLLIWNTMFRGHALSSDPVSALKLYVCMISLGLLPNSYTFPFVLKSCAKSKAFKEGQQIHGHVLKLGCDLDLYVHTSLISMYVQNGRLEDAHKVFDKSPHRDVVSYTALIKGYASRGYIENAQKLFDEIPVKDVVSWNAMISGYAETGNYKEALELFKDMMKTNVRPDESTMVTVVSACAQSGSIELGRQVHLWIDDHGFGSNLKIVNALIDLYSKCGELETACGLFERLPYKDVISWNTLIGGYTHMNLYKEALLLFQEMLRSGETPNDVTMLSILPACAHLGAIDIGRWIHVYIDKRLKGVTNASSLRTSLIDMYAKCGDIEAAHQVFNSILHKSLSSWNAMIFGFAMHGRADASFDLFSRMRKIGIQPDDITFVGLLSACSHSGMLDLGRHIFRTMTQDYKMTPKLEHYGCMIDLLGHSGLFKEAEEMINMMEMEPDGVIWCSLLKACKMHGNVELGESFAENLIKIEPENPGSYVLLSNIYASAGRWNEVAKTRALLNDKGMKKVPGCSSIEIDSVVHEFIIGDKFHPRNREIYGMLEEMEVLLEKAGFVPDTSEVLQEMEEEWKEGALRHHSEKLAIAFGLISTKPGTKLTIVKNLRVCRNCHEATKLISKIYKREIIARDRTRFHHFRDGVCSCNDYW
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSPSSSAKEKTREIERQILNPNSEQTTDDNSPLSAITRMMQGEKARASQAVSRDYSRMAESLEAEMIKYPYADRSPPHHLHVYAHKHNTLLTLTQPNGNPMLSMSCGHLGFRKGGRSGYDPAYQLTSHVFGQIQERGFLMDIKRLEIVFQGFGQGREAFTKVLLGSEGKNIRGLVSRVTDSTRIKFGGTRSRKVRRLG