lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes on chromatin between preleptotene and early pachytene. Associates with the chromosome axes, but disappears from axes upon synaptonemal complex formation.
Sequence:
MENGAEASDCDSDETVIEGSVTENEPEDEELPWRRLLLNQDTTCRSEFCFHSGVDGMQKGIHSPEIQLGLKLRKDSQEQNNKNKLLLALSEDLVLQDPQDKTAQNQVLLQTTKEFPVFTVSFPHPEVSWSHQNTGGHEAENCENLPHSKKELRENSDSPEVSLLSGTSPVAPDLVALKERLTEPVKTLAVPNTLSEPGEEVTQTMTSKETKDEESSLETFVSTLEKLLESSECTQEERLLEVMDDFNPQELFSTLSNSLGSVSVPLNAWAAQGRDELENKADAALPAKLLAAVNTGADVGPSCQGQEKSSSVSGGNGCLAVQPIMSQVDEDCTQIAQNIEDPKPFRLQTLTHENAISYEQINKKKNSDPIKNTSTQETPRVLRRSSRLEKLKASRDVVHTEAVLKKPERILSNTLSFKDQINSIFTTDSFSKRKNMHSSGFKNEQIRKSEQLRKKNGTGEMKKMCLCTINRRNVFGENLLYKAALHNDVDLVRCCIKNGENVNQPSYDGWTALHEASIGGYYQAVSELLKGGADVNVKGKYQITPLHDAVMNRHYKVAELLLMSGADPLFRSDHGTCALDEAKDSSMETLLMKYIPQQKKCHLSAQRNSTDPAHVEDMFQNKKPKLSSNNYTEFICDENFDRQEPGHLEINKGSNNLLMSKEYVCEHCQKDSNTTKFGKSNLNSVKNSRTNVSKRKGQKNRQQKKTQVDDRDCNLSQKIGTSSFRRTNKLLTQQQHAVQTLSDLPEESFELSTTTLSSLENGIGYNEACLVSKKSDTHVLDSSDGQELESVDQTEAASVSELSSYKEIKLLPVTTHQQPHTNQEQYSSPYKSLGNNSSNEKGKATNKWEDSFFSFIKGRSADSDSDCHTLDKSIASPKEGMSHDHHEEIMTGQEVDSQQRLSSENYFSQENDLKVHPLTTHPQEEAVNFCDSNLISVQHTPDYKNCLHEISFGNSYAKTEQSSTSCTRPPSTQKVSPLTVEVELLKGLQDSLAHRDSSPLVNQAGIHSLERKQDTDKNYTKKGPNTSSSSRPLPTVVHSQVIEITKAEKRREDLPGNEPINNTDFYSTDINKELANSSQLNQRKEKENVRKSDAELTHNDSEAERTLKSCEEKKKNMDSETHSPCDIQEHRKDQNFRKRKCSLKAPCSQGVNTTGIGKRNKKGESQLHVAARGGNLSRVKVLIEARADVNLRDNAGWTPLHKAASGGFDDVIIELLQAGANVNCENIDGIVPLHGASAGNHLKAAEILLEHGANPNQKDQKQRTALDEADDEKMKELLKSYGAIESTNGEKRNSTDLVKIPTVQPKRYKQFICDNDKAIGSPVPSHKAKKSESLPVHQTISAILQDIEEKQENLLKLEIRNSEDEEQYIGKMLEIKEVMDNILAQQKTERDDLAKKYRVSMESFKHGALREQLANLATRQKSLLVVAKKQKKIRLKIQNYKNATAVSGVGLRKLPCNSDISSDKKSQEPPTMGDSAHAQPGLLAPVSLAYGSMQEIPLSPEIESESQKINICLNAEAIRREEFSGNDINSKQNVQDCTLGGLLRSKPTDDAEKIASSSQPAALTPHAENSQAEATVKGCGFDSSALTGTINISEDKSIFSPNGACLAADPHSQKLSRCNPKRRNKKTASQQPSAGAAEPLPQAPAVLDTYTVHQTLPCLRDSAAAASHTDSTQSSLSSASAHQHPTKTVPHRNTTPRKKAVQLKDLILRGRINPGNNILEFKTQETTHRASVLPSGKLKGENGQIYQNPVTWLKELLGGGSYVTWNYAWNTVTYLGRELVKCVSEEAPMSAELNPPQLHQPHLSAGTSRESMQTIPHYLQIKEILQISKQELLPCHVMEQHWKFYVGRSHSEALLSW
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MRLLLMALPLLALLPQVIPDYSAEKRCLNRLGHCKRKCKAGEMVMETCKYFQVCCVLDDNDYKQKASITRTMEKTSTIEYNLS
The following text describes a protein:
Function:
Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.
Sequence:
MASLLPRIERLSSRVVRVLGCNPGPMTLQGTNTYLVGTGLRRILIDTGEPAIPEYIGCLKQALSEFNISIQEILVTHWHRDHTGGIPDICTNIPNDSEYRICKLPRVPHCEEIIGDGGHKYLYLKDGDVIQTEGATLRVLYTPGHTDDHMSLHLEEENAIFSGDCILGEGTTVIEDLYDYMKSLKMLLQMKPDLIYPGHGPVVRDANARIQGYISHRNAREEQILNVFQKNAGKSYTSSELVKIVYKDIPENLLLAAENNLIVHLKKLEKEGKVLRDASPSFRWRNNL
The following text describes a protein:
Function:
Functions as a ligand for integrin alpha-PS2/beta-PS. Required in larvae for proper muscle structure and function. Involved in the regulation of cell adhesion during wing development.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Note=Localizes to the basal surface of the dorsoventral cell layer interface during pupal wing development.
Sequence:
MRALGGITLLLAVAICQGYETYQRSSFRSSSSSSYGGGQTVPQLNSFASAHFNEVRELANQLKQKFNVLSQGSTNFAYTSPWSASILDLSGKSTLQLDQLSSEISRQLVQDMREGITNYHTIAQPNFFEAKAAELLERYSGAESASLQQTVGLGPYQPVDLSGFDEVKNYAYPAEVKVIDGKTYVVHRNCTEATKLSDYGSSGQLNSGFLGHQQTSLPLSSTTTTITRKKTIHDWVRENMEPSVVGYNSVVKLDGQLRNSALNQMVPLSPGSNVVIHRFNKTITTNPDGTSSVGGSEWQQRWQDGKLVYDHQQPFGQSTIPRDEQWKREERERLFWYLTTPQRLDDWQQQQEERLLGVVQRYQVSLPVLKEFHRRELARYEALLGQYQSRVQDTSSWQRQERGRLDWLIHQNGFTVQDIERWQNENARKLAEAARQHGISQNQLQQFQREELQRLYVHFNQVNESLAPQVPSVPQTTYNYQSSSSLTEDNTKEQQRLEELIRQHNATIAALQNSIKTDQQRLKNLSIKYQGDMQSQTQWLRGEVARIGDLIKEQNEQVSKITAWQSSERSRLENILLQHRGSVEEVQQRINMDRNYLQNLATKYQVSVEELEKWQKEELERLQVRGQQQLEEHIKDWQISVSSNLRDIATQNKLTIDEFQNYIINDRSHLEEMARLYKVKVEEIEQWIKSELKKFQSEGLLKGVEQELIQWQQKERERLQAIVQQNSLTVEQLEVRIKNDQDHFFKLADKYKINVEDIQDWLKKELLRLQSEGLVKAETLKEWQQQERAQISLLVQQNKYSLDEFERKMLADRARLQELSNTYNVKVSEIEQWIKSEGDRLQHEGQLRMESQLNNWQKIERQRLLDLINKNNLSIEEIESKISKDQTHLYSLAQQHQVRVEEIEQWIRQQIQKLQDQGLIEMQKLKNWQLEWRGNLTNMVQDRDFTVEEFHKWLLKDREQLQSLAMQHNVQIEEIEQFVKKEEQRFIGMGLLKPSEKLTNWQEVERLHLKNLAQQQYKSTEQLEARLRQDRELLERLARQYSVQVEEIESWMKQELARMRDEGQLQIDNLTSWQLAERERLEALIKQNKQWSAEELRAELEKDREHMQTMAFQYHTSVEEIEKWLQSEIERLKQQGKLNIEQLTAWQRTEQQRILSLLQQHSNITLEQFQAKVHNDRRFLMNLAEQHHVHIEEVDNYVKQVIEDLRKNGQFEIEQLQTWQRVERDYIKSLISEYKNSLSTAEYEEKLLADRAHLKHLADQYRINVEQIEEWMIAELKRLRGSTEETLKSLSAWQVSELERLQNLVKQQNHLTFVEFEMELNQERDRLQKLANQYSVNVVEIEEWLRQQLINLRTTGQAKVENLSKWQVEEQQRLIEMLLKKQQEMPYEQVERELTQDHARLQSLSQTHHVDIDHVDHWLREELRRLQSSGLVQIEQQTQWQQKISNGFNNWLEQQRNGASYQDFVDFLKRDKQRMDGIATDYHVTVEQVEKWVQKEAARLSLIGVIERPENNLKYEDISNIWVGDQTDSWKNELVTRLRSVTRQRPFTRQEFESYLIRNKPIFEQIARQYHVTIEDIHLWLDQSAKNEGLVTTEWQAKERLHIDNLINQQLRKQQRWTIEELELRLNNDQKHLQDAVAQYHVTVEELKVWYKDELNRLLEQRRIDRGSGISWQNIESQRIYLAIVNNPGISRQALENRLFRDVHVRASQYQITVEELRQFILSQLRRFSDMGLIVDNGRQANNWHDQERKRLREVVKGVVITEQELLDFISQDTSFQTQLAQSYQVGLEQLAPVQRIFIGNLAREQLLEQRRLNHLTTWQQRERDRLYEFIGNQNMTQTELKTWQIQDSKLLAEFAKRYEISVQQLSDWQKKELARINQLARYYGMSQSDLQQFREGELRQLAYINHRQLLSAAEAQKWEKRHQWTLSRLQSRYGKFGQELVAWRRTLYLLSQGLIDLPADSGSNGGYVVDAGSTNATAVYKPIFSKDRGDQPPHTYDESFVEGDEPGLEGETARPRPPNPAPIVSTPKPPLPYSRGGPSGGFEYRRQDYTFNVPVGSASASASGGPTGSSASASASLGKWNRASGDEPLQQEVDLGQQQQIEELGWNEKLEDLGQQTQVEDTDWNQQAEDLGQQQQVQVEDDLHFDQTQGHSSSSNSRSQPLQQATKVEVEATSEPSFWEKLKEKLG
The following text describes a protein:
Function:
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein. In brain, involved in cognitive function, such as learning and long-term memory.
Sequence:
MGSSSSCYAPRTIYLDVNGRMQKVLFSRHCNSCDIKELLCSSSNIPRNTAITLVGPEGAMVSIDPTMPANSPNSLYKVVPLSTAQPGDKEDLVENVLSQVAEQFSRAFQIKELKTEVINRLAVLEKRVELEGLKVVEIEKCKNDLRKLQDEMSTKHGGRVNCPCKSTLLDDGRKVTPRRDVPSYPKYTLSQETIDALKKPTFDVWHWEHNEMLSCLEYMYHDLGLVKEFNMNPITLKRWLLAIQENYRNNPFHNFRHCFCVSQMMYGMIHLCNLQEKLTLTNLGILMTAAVCHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILSLPECNIFANVDPEAFKKIRQGIITLILATDMARHGEILETFKLNVDHFDFTNEEHVASLKTVMIKCCDISNEVRPAEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKPTAQIGFIKFVLIPMFETVMKLFPQIEEIMVQPLRDSRDHYEELKQLEDAISEESPFMIKLKKDFEKTRMKPQ
The following text describes a protein:
Function:
Could catalyze the biosynthesis of cyclic AMP (cAMP) from ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEVEIKVKIDDKNKVVEQLKKLGFKFIKKKFQEDIYFNGIDRDFRETDEALRIRDEDGNFFVTYKGPKIDKISKTREEIEVKIEDKEKMRQIFKKLGFKEVPPIRKIREIYKKEDIEASIDDVEGLGLFLELEKSISDINEKDKVLEEMMEILKALNISKDNIIRKSYLELRGL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MGEQTSTNAWNIDLNLLPSPEQLSGVMANGTMNLIDLVDQPSDRITETSNGGVALDKTSKKRKNVEKGGGSEGSVFDCNICLDLAKNPVVTCCGHLFCWPCLYRWLHLRSSQTKACPVCKGEVTDKNVIPIYGGENNVEVRHEDSSSTLQIPSRPKARHVSNDSSQTIQWSVGHHGNILVEHEASWSPVEDYGMLAEFQLELEASWSLYDDHVSNDSTNMTPTIHWSMGHHGDIPVEPEASWSTFEDYDMLVEFEQELDELRISL
The following text describes a protein:
Function:
Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYLKKHESKLLLIPKNEDKEDAGIIAVLTDRVPSVLIVRWFDLFCFGFAMCSYVLDFFSDIGIAIFHFWAGRHLSGALVLTFALIPSVIINIISMVWMLDDEMHWKRRAHPRRTGTFELNQKRFISLGKMITLCIFQMGPLFWYYKALYYGWMFTKNKKDDTDKEKRKFFMKMVEAERDATLLRFFEAFLESAPQLIIQGSIAANYFQNYYISGKYPYWLYFQAASLTLSIISISWSVVVQNRSLRMTRDDKVNIWPHEAVLQFCWRFLTILARIITLVAFVLLFGIYVVFLIFGHLIVTLVHVIFLQALHIEACTHIEKLLLLINAMIHLFTPFNMAEGNTRYRYLVAYTVEFIEMMIIFLLLPTPLDAFPLIEKIRIGVPATFFIGIFIMLIYYKFFHPNRRQDLEAPNVERNEKLVVSELNGIPSAAIEKAEHIEEIEEHSVPTTSESLLEEDECHN
The following text describes a protein:
Function:
Probable membrane-remodeling GTPase that plays a unique role in the in the determination of thylakoid and chloroplast morphology and regulates organization of the thylakoid network. Not involved in the determination of mitochondrial morphology or ultrastructure.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Localizes in a punctate pattern in chloroplasts.
Sequence:
MRTLISHRQCVTSPFLISAASPPFPGRCFKLSSFTPPRHRRFSSLSIRNISHESADQTSSSRPRTLYPGGYKRPELAVPGLLLRLDADEVMSGNREETLDLVDRALAKSVQIVVIDGGATAGKLYEAACLLKSLVKGRAYLLIAERVDIASAVGASGVALSDEGLPAIVARNTLMGSNPDSVLLPLVARIVKDVDSALIASSSEGADFLILGSGEEDTQVADSLLKSVKIPIYVTCRGNEEAKEELQLLKSGVSGFVISLKDLRSSRDVALRQSLDGAYVVNNHETQNMNELPEKKNSAGFIKLEDKQKLIVEMEKSVLRETIEIIHKAAPLMEEVSLLIDAVSRIDEPFLMVIVGEFNSGKSTVINALLGKRYLKEGVVPTTNEITFLCYSDLESEEQQRCQTHPDGQYVCYLPAPILKDINIVDTPGTNVILQRQQRLTEEFVPRADLLVFVLSADRPLTESEVAFLRYTQQWKKKFVFILNKSDIYRDARELEEAISFVKENTRKLLNTENVILYPVSARSALEAKLSTASLVGRDDLEIADPGSNWRVQSFNELEKFLYSFLDSSTATGMERIRLKLETPMAIAERLLSSVEALVRQDCLAAREDLASADKIISRTKEYALKMEYESISWRRQALSLIDNARLQVVDLIGTTLRLSSLDLAISYVFKGEKSASVAATSKVQGEILAPALTNAKELLGKYAEWLQSNTAREGSLSLKSFENKWPTYVNSKTQLGIDTYDLLQKTDKVSLKTIQNLSAGTTSKRLEQDIREVFFVTVGGLGAAGLSASLLTSVLPTTLEDLLALGLCSAGGYVAIANFPYRRQAIIGKVNKVADALAQQLEDAMQKDLSDATSNLVNFVNIVAKPYREEAQLRLDRLLGIQKELSDIRSKLQLLQVDIDNLHVSRDEMRL
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MADDVEKAILITFRFDGSYTPQLKEQAAAYVNNIKRSPECWQLCLERFSASGYTEVKFWCLQTLHELIRANFVSLGAPEKATIRTALLTWVTRDCNNPAAPLPAFLRNKVAQTLVAVLQYEYPTNWPSFFHDLIGAMAGGEGVVDMFCRILLSVDEDIVSLDIPRSQDESRLSMRVKDGMREHSLQEIAAAWFRLVGGYRDKAPELAGQVLAVMTRYIPWIDIGLVANDKFLPLLLSLMDAPHMTLRGAAVDCVTEVLSKRMEAVPKLTLIQSMKIVGTAARWSGGFPVRLPGPDMEDEEAAGVVVKFARLLAVLATEIMDSLKRVENGVISLSAVGFAVPDEAAGEAARAVEAAGGMLAALFPAVLAAFGSGCDDVALPLLPFMSAYVARLKGLARRPAGLSPDTLGQVRSILEGLAVAAKYPQGPNAASYGGPPPTQPAALAAAAEEAEAVSDKRRELFTLFRNIAKICFGEALGFVGAVLGALLPRQDVAWQDVEVAVSLLYELGEGAPEEALKLGGGGGAAGAAAGAGGQAGADAANGPAGGGAGAGGGAQGVAAAAAAATGVPAGGLASLFLVLVQRGPQPAAVARHRLVALAVLECCVRYSRVLQQVPPAIPPALAAFLDGRGMGHPAEDVSTRACYLFSRLIKALRQNVRPYLSDVLTSLQPHLQRVATTPLAPGASASAAAAGGGAAAAAAAAAAAAEAVSATGAGKASAPANACVDDRLYVFDSVGLLLGQDELPPEQQLALTGQLMTPLMRQIEEALPALRAGSAAGGSAAGGSGVAAAAAAAAGGAAAAALVMQALEAINRLSKGFRTDTVTRTRPALGTLFVRSLEVAVAAPAAAPASKALRSRFISFLHRMVEVLGGGLLPYLPPALEVLLSTQSDVQDLVDLVVLVNQLLARYRDALAALLAALLPPLMMRIHGALGPDWDWSGKTATPGAMTAAADGTSATLEEARERGELQRVYYLLLSAVTTAGMSGALLKVPPGVLEAAVLGLTRGAATHVDPTVRRTCLQVFSRLVGDWCGSPAAGATAAAAAGAAGSGATAAAAAGAAAAAPGGEVVPGFRRYAMERLGEEACLFGLLRSGGGAQGGGGGGAAGGGGGGGLDVRDAAVLNLLGDAAAALKLIYSKCGEEFPGHLVGTVFPALGLAGHAQQQLVFLIREGEAKALRDYLRELMTQAQQQQQQQQQQQGAAR
The following text describes a protein:
Function:
Transcription factor required for differentiation of embryonic stem cells (ESCs) into primordial germ cells.
Subcellular Localization:
Nucleus.
Sequence:
MEAEGSSRKVTRLLRLGVKEDSEEQHDVKAEAFFQAGEGRDEQGAQGQPGVGAVGTEGEGEELNGGKGHFGPGAPGPMGDGDKDSGTRAGGVEQEQNEPVAEGTESQENGNPGGRQMPLQGSRFAQHRLRELESILQRTNSFDVPREDLDRLMDACVSRVQNWFKIRRAAARRTRRRATPVPEHFRGTFECPACRGVRWGERCPFATPRF
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Sequence:
MQSTSETTHSPSQTEAAQSEAQPQEDQLEDERHSRPGRRDPNGGTGPRGRYSGLVDRAEKRAPPEHLLDVVPQSSGIETPQHQGGPAVAIKQALDARDKKGSVDEAWALFEENYTSRDCEALTNPHDGDLALLKNGQIFTELLQKVNGALCNAPGKYTTTPTKVLFKYEQLGLATPELWSRTTLPYLTQTAMFIINAPSTNSKNLPSILSELLSLWPQIGNTSLGFLAVYFYTLSDALSTIETLYKEAEPFIQFLQRILADSSVVSVYKYPQNSAGFKKLPKQVQAEILKEIDTAPYRALEQIAAQGATMKNPTSSPETNLELFQLRRIARAVLSKQSSSVLDVLWNDIQRMYTNDGSPAIPRRIYNAFLSGYLSLFASQRSVEVWNHMIAHGVQPDLQSWIALLQGCETAKDYEGFDAMWKRMLNTGIEPDNYAWTTRVHGLFGLRKIDEGLAALDDMGRRWLFAENAINLSDSKRKGAKRLPTSAKAANKCTKPSIEVINGAVSALAQLPLTAIRQEKRVGYVQKILGWAGNFSIKPDAITYNSLIQLYLRAGDYSTAFKILRQMEKEGIAADIATHTLLITASFDNGSFAGLTAAQQTQKIISVLDSLEAGGIKLNDHAYSIAIDRMLKTYGNHKAVNSIMQYMQARNRALSAHAYVSLITYMFQQSPPPMPAIDSMVDTFFTSHRVSTDQYLFDRTIEGYASHGETSKMMSVLSRMRRLGALPGWQALTTIIEALYKDGETVRARQIVREVEGGEGVGKAGVVGGRAGENRFFHTAQRLGLYGEHDGREDGDMDRGMGRMDDFVVSDALSRGSQNEQPLETHQKRQQEQGIPRSRPDAPLHQERAPAPSADEEDVHGFLTDDYEDTHPKANRQ
The following text describes a protein:
Function:
Essential for blood-stage parasite viability. Required for apicoplast biogenesis. Associates with the apicoplast genome and mediates apicoplast gene expression. Can bind heme. Can bind protoporphyrin IX.
Subcellular Localization:
Plastid, apicoplast.
Sequence:
MIRKIIILMFTFFSNIHNEKIYHHKQRRKFLKGPLGYLNRNVIQKKHYNLYAKKFINYKEIQIQRINDYRKRSGVDKNNINYNLRDTYNYHETHLFVRNEVLPTLAKIENENLKEKEKNKEIFRNINDYNSNFTRQTFLQFLMDLYNIFLKIDDLFLENKTYFSILIYNGPMQLTNHLYDDIIYVSSVVENSDDVSPSEYCMEYISHLENLCEENKLSFLAHAYVFYKNFHLSKEHLLKSICKYLNIIKKLKSSTYVADVENFEFCLNKMSRKWSRWEKDNFLASLHNATNKMMILTKHFEKVKS
The following text describes a protein:
Function:
May be a carrier protein for lipids.
Subcellular Localization:
Secreted.
Sequence:
MIRYYIVLLLYFFAPPVLGISEEMQELVNQLHSTCVAETGVSEDLINKVNSDKVMIDDEKLKCYIKCLLTETGCISDDGVVDVEATIALLPEDMKAKTTPVIRSCGAKMGANPCESAWLTHKCYLETSPADYVLI
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MTMALQVGQFDIKNIKYTLTNKVYFNTNDYKSFEQPEYVKIDNFVYTATSLDIVEQGKLYLSKVQRTDLNLGLNEQVKITKFEPNQTQRCTSYLRIDIGFFNRPTQIEIDAEDIRKLIKNDFNKQMVTQNQSLVLTVKGVPFLLKFVEIQLVGAKGEIIENADRGLIHEKIMNIDISKLGRDGGLLTINGGMTQGTLFTKNFNPEGMGVGGLDKEFTDILRRAFMSRMFPSETIKKLGIKHVKGILLYGPPGCGKTLMARQIGKMVSSVEPKLVEGPSILNKYVGESEANIRNLFAEAEAEQNQRGDDSQLHIIILDELDAICKQRGSRNDSTGVSDTIVNQLLSKIDGVNALNNILVIGMTNRMDMLDDALLRPGRLEVQIEIGLPDEHGRVQILNIHTKKMRENHMLDSNVSIEELAKQTKNFSGAELEGLVISASSFAMKENFDMEKCKPRNDKFVVKREHFDMALGEMKPAFGVDKDDQIPTLPNPMLVYSSAQMHVREMLKDSVQQLSTSTVTNKIAVMIGGKHGSGKTALAVEAAKQSGFPFIKVLSAEQLVGYPDVMKCSKIAKVFTDAYRSTQSVIIIDDLERVLEYTPFGPRFDNTVLHLLLAYIRKPVPTGKKLYILSTTCLAPDVLRNLDVWEAFTQHMHLPIVTGCEQLKTIARTSGMDSNIDELGWVDVMNQFQNKEIAIQNALLLLENFKGKSYDSKEFTMLMNTYCSEEIDPWDSIAYMQA
The following text describes a protein:
Function:
Involved in the structural organization of the cis-Golgi and in vesicle targeting/fusion stages of ER to Golgi transport.
Miscellaneous:
MISCELLANEOUS: Present with 7620 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus lumen. Note=The Golgi localization needs the presence of ARF1 and ERV14.
Domain:
The GRIP domain binds to ARF1, which leads to the Golgi localization of RUD3.
Sequence:
MGKNKKKTGKKAKSHPHVEDVDETVNKPEEIINSVNVTVPPKMSTDPEADGIVASPDDEGKDLSEGVDKQKVNDGLTVDTINPLEDKKAGDEMKELREEIERLKLELSHKKDQETPNEDFKNELANVIKERDEFKTQYDTLLSKISSMKSIFNKMKEAQKQLEEVQEQLTEYESQNLKLKKKLEATKTENSELQSTIVTLNTELENLEKEQESTEEVFLEYESRIEALEDEKHDIIEKHSKELNTYRKEKDQLNLQVQELMIILENNKQDISDLRTERDELRQALESHEKEKAVLKNSLNDLELKIEEVDNKREEEARERDQEVKSLRSQLDTEIETHNNDTEALESMKKQLEAMKEDASMKEKYEEESKQHILQIGKLRHEAIILNEHLTKALAMLKKSSDSESVDKELISNLLISFVSIPRADPRKFEVLELLSNFLNWDEDKKQQAGLISNNESKNSSAVSRTESFVSLWTNYLEKESEKD
The following text describes a protein:
Function:
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
EMRVAVIGAGCCGITAVKACLEENLDVVCFERSSNSGGLWWYRDDEQEPGRSTVMRFTVANTSKEMSAYSDFPPMKEMAVYMTHGQTLRYIRSYAEHFGVPSRIRYRHHVIRLGTDGTLTVLDLDSGREFEETFDSVLVCTGHHATPSIPKFPGLEKFKGRVLHSQHYKYADEGFRDKRTAVVGFGISGADVAVDLTTVTDRVLLVTRRMSWIYPQHIGGVPTDAYILNQLRLWIYSWLPPYFFSRHFQRICNQEFDHKLLGTQPPHPLIKQAGIPNHILPLKLLAGSTELRANLEAFTENGMVFNGVEEPIDAVVFSTGYTNEVPFARDILPAGGQRLPLYKRMIPPKHPNIAFLGYIDASLNLSQGFEMQARYMASVLTGKLTLPSTKVMQDEVWRVHDLSKRQFLDTPRHYLMVDRVAYVNDLARAIGAKPKYYWLFLTDIKLWWTLITSPLLNYQYRLRGPNAWPGAREAILGYAERMRAPLQVSMGSRHQVKKRRRLKTWGIVPVVAIVIISISVKSLITTAAT
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MVHNRIDPPFTRYLDSDGRPLGELPAWAGDSDALVGLYRQMLLTRLFDQKAVALQRTGRIGTYAPTLGQEAIGVAIGSQMRAEDVLVPYYRDTAVQLMRGVRMEDILLYWGGDERGSDYAEPLAAQDFPICVPIATQALHACGVASAFRIRGEHRVAVTTCGDGATSKGDFLEALNVAGAWQLPVLFVVNNNQWAISVPRRIQCGAPTLAEKAVGAGFPGEQVDGNDVLAVAERVRAALERARQGKGPTLLECISYRLCDHTTADDASRYRSAEEVNQAWREEPIKRLRAFLAGRGQWDEEREQALVGECQARVQEAVERFETFAAQAPQALFEHVYARWPAVLEEQREQLLERAARRRGGAEHE
The following text describes a protein:
Function:
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSYHVTEDPIKKVAIFGGTHGNELTGVFLVKHWLENDTEIQRTGLEVKPFITNPRAVKKCTRYIDCDLNRVFDPENLGKKVSKDLPYEVRRAQEINHLFGPKDNEDSYDIIFDLHNTTSNMGCTLILEDSRNDLLIQMFHYIKNSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVGPQPQGVLRADILDQMRKMIKYALDFIHNFNEGKEFPPCAIEVYKIMEKVDYPRNENGDIAALIHPNLQDQDWKPLHPGDPVFLTLEGKSIPLGGDSTVYPVFVNEAAYYEKKEAFAKTTKLILNARSIRSSLH
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSNKVLLADYNNHGNQQFEYPEQDIYYTGRKLNQDLKHGPLEQRGCQDILCVILYLSVWALMIFCAINSWEAGDASKIYLPYDSQQRQCGRGDLKSYSNIYIISQTESYCVSECPGESGVGKELPCYQCSAQTAPYASAQLLTLCFPTLKVDEKYKELITNIVDISGFQRHYADIEETWPIILACAGIAFFMAIILTFLIRLAAGCIVWGMILIYLLILGSIGTVAFLQSKGHYQEYRVLDDAQQLEIIAYVFWSIGLLSLLIILCLAKKISQAIQVLKTAADFTREEWQALFVPVVILILVLAFFAYWIIFSAIIYSTSSDISKSQYSPYVELQWDAKTGWQLCLYFFALIWNVCFSLALCQFVISSCCCFWYYSHQGYPLSSSILKSFCRGFTTNFGSLLFGSLILAIVWTIKFVLEFLHKQLKQSVQGDNNAIGYALRCAKYYVSCFEKFIRFLNQNAYTMMALTGQSFCNSAYDAFYLILRNATRVAITHGLGELFEFLGAVFISASSSFICYLIITKAEAYKNNIFNPVAPTLAFILVSYMIGKMFMNLYGMGVDTLLLCFIVDTEMNKNEGGAKSVPHSLKQYASELN
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MDEDDNLSNADISIDDEEVVREQTHHPPMQEDQELDNEDGSSDVDLSSVYVVPPIVSAPSPASVRIAGGSTIGGGGVAAGAVPTTTDNSHSPFHDWDSSVAAAAAPPPPPPRTGPTTTTSSGTAAESGAASALSDDAGAKPSFFFGASSFSLRSRKEVAALINTECCRGSPTPDLDSIMDTLFNPGTPIDNLDNIEWIRWLIAGGRTPQEFVKIVRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDTSVMKAEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFREHSDTPLEVQAITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNGRFLKANREKYEDAVNRFPNPEPPDEYRDLPALGDKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLTRTFVMHYSRIPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKILIQNTLHDPNKNFHFVIDCTRQVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRETASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHEWLDSIYFMEARLSMEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPLRVQSFFYEILAGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLETAPLKQPQKAEQSSMLEGFLTFLATLVTSRTNLGNDEATQCIIEISALLATENKTHSQLLELMPERSGNVHTKNFETFLKKLSVYKAPSSGSENLEQGLFTPIDEVWEKHYDPLHVLLRAVHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHSTILSIFFRAVHTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGRHEPPKLFHCYPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRRNVSQALVPMRVPGMEVALPPDLSVVAETGVVIRQDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSGTLDSFSLSDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQDEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQKLFMQSAAASSSGMGYGPEDEDDEELYEEQPREKEYDCIICNCTTPSTESNPIGLVVLVESSGIVGHRRRIAERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYDNGVHVQSCGHHVHLSCLEAYLKTLYTTQRQPVQDRGEFYCPVCRQLSNSVLPLSPQLDRPTHLVRSGNQPFERLVADLTDLIKENETIPQPTKLTEAMGHAMEVMTNIAQRKVKCSSITFRKLFIFVTSIARTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHVRVLVEWPLWSSWASLAGLPVTATEPLPAHCLELIPSILADPIALLLKFILLAPLQLDQDYFTCMVKVMYNLLYYQIVVQLCVTLTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQQQQSSSQLGKAMALVLSQTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATTIEVNLKSMELQLQALCLPFLRVAALLRQHLYRHEMPEISAPGLEFVRLVYYLELVTDSMDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQQPRLLELPREYERLFTYYHERPCLNCYKVPKESSICLLCGTIVCLKQNCCAENDCCEAVRHTLSCGGGIGIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSHKFAHTKHTWVFHRDLLXNMEDLLRSIQELVGQI