lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Spindle pole, half bridge.
Sequence:
MSKNGAPKYVDGGRKIMDEDLRRDLEILRLILLRLSHAADDTSPLDVFNAYESVLRENGLNPARHRSYIRILYRLISSKKLSWNDEWRNLMRRIGFSQVSSDLNTPLFPLNNTDMENDPFIVNGDDYRSRSNQQKSSQFASEVAQTIKSQTAMFRRADQYRSQKDKILLANSLDFMLEKYRYYKKIDAVYLRKADAVYRAFIMLKYFPRWVQKLRNIQSRIYSAGEAYRLILIGQMVNRWRQKTRERLHQKLRFQKNAFLLDVLLKWSALTVNWNRKHEYMLKRRVFTNWMSKRRRNESLIQKANVFFQHSVLAHSFKTWKANLSIKNAATLYEKKVVFMSFNRWHANYESHVLDLQKAELFSQKAYYSIALHKWKLRIEELSDLMNKADDLYEVNLLQRMLVLWRRKATTYEKIDFWMDGHDVDIVKSAFFKWKNKFIKVDRNFELADTILQNTFLTKWRLAVRVKVVQEKRNKDRLIVTFRFWYYLMKAKSFQHKRDHRLLTIAWEAWKDNYQRRIKLQKEAQELQLTRIQKIAKQYLIKWRISLLDIKELSIRAEKLHTTNEIIGVWNQWVVSYNRKVGMQQNADLFFKRKTLRVVFEHWRYLRETNMLLRLENKVVDFREVQSEKLVLRCWNAWVARLLSVSQMLDTAELSTQKVVVRAYEAWSFRYNHQKEIMSQADQFYNERLMRSAMVFWRYQLRAIKFYFNISDWKRREFNRQTLRNAFDAWHLLMFRVTSLVMQADRFHEQKKNKLLGKYFRKWLQRMQLNQEESSLLEAEATIEGNRTSRYMHTFDTTLPMQNDEFTDESVNFENRWKQELKTPISRFSKFLRPIPPNTR
The following text describes a protein:
Function:
Sperm protein required for fusion of sperm with the egg membrane during fertilization. May regulate the expression of sperm surface protein DCST2.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein.
Domain:
The extracellular domain shows strong structural similarity with IZUMO1 but does not interact with the IZUMO1 receptor IZUMO1R/JUNO.
Sequence:
MFVFIAKLLIFSSVITSAFTCYQCFIDENDSRRLCLGHILTEYNVRNVDSCYKTLDRIFNNEEKVIEAGKVGRGYDLTLKNILMAEIMPIVEEFDQQLNYDTEYESRLQAAANNFIAAASSLPRVSGCLPPCGFQVQGAVYNCVTCQYDSCEFPLDCPGKEITVQENNRTQMWCSVPFLLPADVEIVWRYAQDRTMLRERFDDVTVGVDPLYSIPSARPEQSGTYQCEVLSQEQSLVRLYFYLTVVPVAQTYHVHLQDLCAQALRPEPQFPPSFSFWLPRPALLITCLTATMLLIFLSLGAMCRLWYQIRTNVSNPA
The following text describes a protein:
Function:
Required for normal levels of meiotic recombination. Acts in the recombinational pathway of double-strand break (DSB) repair together with rhp51, rhp55 and rad22. Required for the full extent of DNA recombination and cell survival under condition of a replication fork collapse.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNAAEWVAELKRKSQIESFKEQKGLVYDDHIEKVLYSGSVNGTLLVIEGNSCSGKTELLYHLASNVLLRSSQELVLIVSSEWDWSIKRLTFILHERLISSRGVSQTCKCNCAVKLENESTVHLQNAAREDGTDEDINSNSVNDVSLSSGETMLQFPEHEEQHECNREMEQLYESASSTVYPCSFWEDAERKIDAQCAILWPMEFSGVVESIPQSTKDLLRIWKEAKIQMHEDFRCNKTEFNEACFDASSSRLGCILMDGLSTFYWQLRLERGYTQVYADLQNRLCTSSKLFGCPVVCTNWLLNNKQHLPIQCKRFRSERRANARFYLENCVSKLGETFYLSVKGVQTKTEMASPYSQQEMEKV
The following text describes a protein:
Function:
Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid. MhpC shows some selectivity for the carboxylate of the side chain.
Miscellaneous:
MISCELLANEOUS: MhpC is not a serine hydrolase (catalytic triad), as Ser-114 is a non-nucleophilic catalytic residue and Asp-239 is not involved in the catalytic mechanism.
Sequence:
MSYQPQTEAATSRFLNVEEAGKTLRIHFNDCGQGDETVVLLHGSGPGATGWANFSRNIDPLVEAGYRVILLDCPGWGKSDSVVNSGSRSDLNARILKSVVDQLDIAKIHLLGNSMGGHSSVAFTLKWPERVGKLVLMGGGTGGMSLFTPMPTEGIKRLNQLYRQPTIENLKLMMDIFVFDTSDLTDALFEARLNNMLSRRDHLENFVKSLEANPKQFPDFGPRLAEIKAQTLIVWGRNDRFVPMDAGLRLLSGIAGSELHIFRDCGHWAQWEHADAFNQLVLNFLARP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (By similarity). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (By similarity). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (By similarity). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). Binds polyubiquitin of different linkage types (By similarity).
Domain:
The RanBP2-type zinc finger, also called Npl4 zinc finger (NZF), mediates binding to 'Met-1'-linked polyubiquitins; The UBL domain mediates association with RNF31 via interaction with its UBA domain.
Sequence:
MDEKTKKAEEMALSLARAVTGGDEQAAIKYATWLAEQKVPLRVQVKPEVSPTQDIRLCVSVEDAYMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPSLQQWVVGQRLARDQETLHSHGIRRNGDSAYLYLLSARNTSLNPQELQRQRQLRMLEDLGFKDLTLQPRGPLEPVLPKPRTHQETGQPDAAPESPPVGWQCPGCTFINKPTRPGCEMCCRARPEAYQIPASYQPDEEERARLAGEEEALRQYEQRKQQQQEGNYLQHVQLEQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVCTRVNCLLCKAIHERMNCREYQDDLAHRARNDVAAQQTTEMLRVMLQQGEAMYCPQCRIVVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGKKKDGVDKREKWSPCERIISTNQTTAIFSHGSSCLSTMSNSRWPVLSHEKAWKLRFNGGIDTHVPNHSSSPVGYTREFQSMLMEGLDEDGGGDDCAGGGQISEKKRRLSADQVKALEKNFEMENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWKTKQLERDYGVLKANFDSLKHNYDSLKHDNESLLKQIRELKSKLYGEDEESNIPVKEEADEKQPKSPEVMYENENMVTTTYFPDLKDGSSDSDSSAILNDDNNSSNMTTSMADVMKGHQLTESKDIMGAAQKAYQPQFVKIEEHNFFGGDESCNFFSDDQAPTLQWYCQDQWNLTDEN
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MPNSETELEERLKEAGNSLLNPPSSVDDLLDSLDKLERLLTNVEQAPSRSMQDALLPPMKALISSAILRHLDEDVRVAVASCMSEITRITAPDAPYNDDLMKEIFQLTVASFEKLSHESGHCYTKAVSILENVARVRSCLMMLDLELDELILDMFQYFLKFIRSNHPQIAILAMETIMTLVIDESEEISVELLTLLLVSVKKQNQSFSPIAWKLGERVITNCAAKIKPYLKEAVQSTGIPLDEYAPIVASIFQDESHTLECDYNNHSGEPLGSSPNAACRKEVFEGKDVIPKSIARNGTASIRNAGTVKKDNASKMLEPCSHTEHSKSTNAQDKAEPEVMLEMEPKAVPSKRGWKPNSLMNPEEGYDPWFSTGRKTTKLLREKLQDKGNDDLPSETPDSKKVALSLMHVKVTKPTRFTPKTVQISRSSSLTPQQDITAGSHFKRGRPKKKGNSMSEDADPSPSLLSKRESMSAQVEEKAPEFDDASLRKQSKERSDSEAKKQKRLRKNELGSKTPKKISLSSGRVVSSKKSVVLSEPEEKPVHQPVVIAVRRFNKHRTAVPTGTKKKSLDVNSDEDVGEAFRDKKIKSLDMDGSYLEETPQPKLKRKRTPRKEVFSGTPDLGEQLVGNKIKVWWPMDKRFYEGVVDSYDPIKKKHKVLYADGDEEKLNLKKQRWEFIEDGIFPVQGQEIDVPKPGTSSDILQKVNSETKSESKKKSKAVSSSKRSRAASISKTTARRFAGKSAYGAVHDEPIRVDKPADHDTSGPGSGSEDGKNTPGPGGSSKDDGENSTVKLKIHDPQRIDNNSKQAMPETVNTSDNGSPKAGTVFCSFNSEQTMPVGATLSKDESSRGGDESHGSDGPKREQQGEASSSLSPETD
The following text describes a protein:
Function:
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Colocalizes with Sas-4 and Patronin at the microtubule organizing center. Colocalizes with Alms1a at the mother centrosome in male germ stem cells.
Sequence:
MLSNRAFGETIEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHSAPGALNVFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQVLPQIREEFKQVHHKLPYEQTGLFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLKEDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPPDLQIPSGDCVYNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMETMTDFEIRFYSGAKLLKTPSEGLKVYDRNGMLLSDYSCSESRSLIEHGNECFTHCVNISNALEVAQTKDNSCFPVTIGRRPITDVQPAQRLDGLRDTTNIAFSTPKSNQGSINFSLSTISSTRNTSDFGTNCSRSNMLAAHQNIPIKRINVPEIGIATELSHGVVQVQFYDGSVVSVIPSMQGGGITYTQPNGTSTHFGKGDDLPFPVRDRVGQIPNIQLKLKTAPLLGSGRKTDYNNAMTPKTTTPYYNRMLL
The following text describes a protein:
Function:
Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus matrix.
Sequence:
MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVGTDKSFTYDFVFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQLLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQAQMSKELVELNKALALKEALARKMTQNDSQLQPIQYQYQDNIKELELEVINLQKEKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIADLQQKLLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTSCADMQKMLFEERNHFAEIETELQAELVRMEQQHQEKVLYLLSQLQQSQMAEKQLEESVSEKEQQLLSTLKCQDEELEKMREVCEQNQQLLRENEIIKQKLTLLQVASRQKHLPKDTLLSPDSSFEYVPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDDDEGDDEEWKPTKLVKVSRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCCCDPTKCRNRQQGKDSLGTVERTQDSEGSFKLEDPTEVTPGLSFFNPVCATPNSKILKEMCDVEQVLSKKTPPAPSPFDLPELKHVATEYQENKAPGKKKKRALASNTSFFSGCSPIEEEAH
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
MLLRCSYNPINGQTTKSKGRLASVSPLNPSTREISKVRNPKQPSSLPHIPFCSKRRQQLGQAGRLFVENHLIPLCFQTDHKISVIEVADSFLSLPEAGRGRPTPLEGVFSLHQMPLADPIPQGQELGNSIIREIGVDIMNPSIAQKPLSHRDFQVIPPSLRDKRRQVRRDPPIVDRGAPAARATGSRDNNLAPLDLQIPTVFENAYYKNLVAKKGLMHSDRVREYVGSQGAFFADLVEGMVPLTGSDGQIRKNCIRRIN
The following text describes a protein:
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Sequence:
MPKREREDSKDSCSGDTSCSTDSSTSDSSSSCSIFSSSSGSAKRRSKKASFEVHKIDNGNSGDTTSKSNTSPRPNDGAVKLDVSAVLRAELQPKLTETLGDHALEPVYGIKDENNGNSGRAVYEDGGGMQHEGYGNISSDNDSLDDRFGTSASTSSTDADDEAVEDFRERLLAHAQVTSAAKKEHSTSIESEGLLGSGLNPARALEHLRKALLKPVSSTALAVVSATDESHDLMDAVVSAKLPPPPADDVKRLRKLHYVDHSTIEYPPIQKEFYVSPPDVRGLDAGELKELLKELDGAKVRGRDPPRPMRSWTGSGLADSVLEALAEGGFQQPFAVQSLGAPVLMSGRDLLVVAKTGSGKTLSYLLPLIRHCMGQRACKKGEGPITLVLVPTHELGCQIVRVAEKLCSAAHLRLVASYGLVPLSDNIKQCRAGCEVMVSTPGRLLDLLTVGGGGVLSLRFVSFVVVDEADRMFDSGFAEHVEAFLKNIRPDRQLAMFSATMPKELKKVICRHLHDPIEITVGGKPTPASNVEQRFFFFDEELYDVDVESRSEDKKFLKLLQILGEEGGNGEHLILIFTQQKKECDELFARLSACGYNKRIAVLYSGMDPIDREFALEYFSPGNQFILIATGVAERGLDIPYLELVINYTLPDHYEAYVHRIGRTGRAGRKGKAVSFFTRGKDDELAADLCEGLERAEQQVSEELYERATKVRELRKGGTARHNALFHRGYMRAKKQRFTNRDQKEQFKTALRAAGLEDDMPTGSDSDSGFSSGDDSDVGVKIKAVEEDNADDSCDAELSSALTIHKGDGALTVSSAQLQKQKESLEAALAYARKTTEMAVNPASRNVRFEAEYPINDLPNVVRLRLQNSAVLRSVAEESNSTIVRKGVFYDKSLKHSHRLRDGVRPLYLLIIGKTAESVRDTVKKLNSVKEEAQSRLQQKVSSVGAQL
The following text describes a protein:
Function:
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MVDNTHDTIEAFPLRNYLFIEREGQPEEDNSVTNRLKRLEDQYKESGTRRSVEAIMVVTVHGFAHVLVLQVANAFYKLPGGYLDPSESDAEGLITRLNEQLGVPVTTLKGKDEDDLPRTVWLAPEGGRDWEVRDCLSVWYRPHFDTFLYPYAPAHVSYPKECKKLYLVNLPPNKTFAVPANMKLHAIPIFEFYDNAARYGPQFAGIPYILSKFVMSQPEVCEEDERKVYKAVVPSTL
The following text describes a protein:
Function:
Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins.
Subcellular Localization:
Mitochondrion.
Sequence:
MASQVNALLLPVIESTPLHQITKVALTTTLTSKQSDYKFKEIAVPLTKSLQLYEKAQRRQDLRASLKALESIIYQTHFQWNNPLPRHAHLFQKHYHFLLTHWPFENHRDLVDSIAVNNGKLNSTSSRSVWLKADWITLFNVKNPWVQTPPSLMRLSGTDLDTFTPERIFLINSLGNHYKFLIANSHLSYNHKKYPSPGVQIPVRNALGEVSPAKQIAQLFARQLSHIYKSLFIENPPLSPENELALTAVFYDETVERRLRRLYMRACARAYTTTNADSTTEPLMFHCTRWEVD
The following text describes a protein:
Function:
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
Sequence:
MYPWQDFAIQPDFSDKIALRTTQGDMLTWIELTTKINQTVAFLQKKGVNAESAVAFVGKNSEKILFLYLATIQLGAKVLGINPAFPQEKIAKLCEFYQIDFCFYDKDLLNLQEIDVFTQKADFFRPATMTLTSGSTGLPKAVVHNVQAHLDNAKGVCNLMKFDCNQSWLLSLPLYHVSGQGIVWRWLYCGAQLHFPEDDFYASLLKTTHVSLVPTQLQRLLDYLQENPSISFATRHILLGGAHIPTELTQNMLKYGIETYSGYGMTEMASTVFAKKSDRKQGVGQPLLGREYCLVNDEIWLKGAGLAMGYWKDRQIVPLTNNQGWIQTKDKGIWQEGELVIIGRLDNMFISGGENIQPEEIEQVIIQHSSVNQVFVLPQKNKEFGQRPVALVDFNEPFSKSAVENLMFFLQDKLARFKQPIAYYPLPLMLEKGIKISRKQLADWLAKRDEIN
The following text describes a protein:
Function:
Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cell surface. Endomembrane system; Single-pass type II membrane protein. Secreted.
Sequence:
MINTYNTTLPPPLPPRQMARVSSGSPTRPVIWFLSAVILVHMVVSVIMFMYLFRKVEEFQTLVSNHDDLILLRRLHQCEAQTQDKSSLLDCAKVVSKFQSLLSKASTMQESLQAGLKGDRPTTAVAHLRVKKNPGSPTGNKITQWSEDHSLLKNVDFDSFRSMIRITTPGIYYIYSQVTFSKTQDKAPVVQNVMKEWKGQESTLLTASSSLSNSRDPSLYTIYQGGVFELKKDEYLYVKVTNLSLVNFNENSTMFGLFMV
The following text describes a protein:
Function:
Probable transcription activator that may act as growth regulators in response to water deficit; Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MTEGEEYCLARMSVDPFMAMKKSNYNKNNQRRFSDEQIKSLEMMFESETKLEPRKKVQLARELGLQPRQVAIWFQNKRARWKSKQLETEFNILKQNYNDLASQFESLKKEKQALVSELHRLNEEVQKTHEEKRLCCGDQAAVVALSSTDHESENEENTRREQEEEVRPEMEVCEKGDDGVLCGHHNDDYDDGGYNNDIKREYFGGFGEEADHLMNIVEPADSCLTSSDDWGGFKSNANLLDQSSSNCPWWDFWS
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKKKSEDHSGGDANDSDYNEEPNFEDPPNFVDNISDDDLLGDMLAQRPSEADGVESVVVVDNIPKVEPVRLEKLKSVINKLFSHCGDIVNVVYPVDEEGKTKGYAFMEYKHAGQAEEAVKKLNNHRLDKNHTFAVNLFTDFQKYENIPEKWEPPTVQSFKVQNDLYNFINDPDAYDQYCVAAETSQNCVQVGFWQNVLPEPNELETRERFTDTFVKWSPLGTYVVTFHKPGVAIWGGSSFQKIQKFPHTGTQFVEFSPCENYLVTYGPTPTGQKIIIWDIRTGAEKRSFVADGMSVLSMFRWSHDDKYVARMGDNSIHIYETPSFYLLDLKSIKIPGIRGFSWSPTDNVIAYWVEEQNQIPARVTLMEIPKKRETRNKNLFHVADCKLHWQKSGDYLCVKVDRYSKLKKDKKELDVKFLGMFYNFEIFHMREKEVPVDSVEIRELILAFAWEPIGNKFSIIHGEPNSANVSFYEVNKGVKPSLVKRLEKKSCTHLFWSPRGQFIVMANLTMGTFEFVDSTNDYIISASPDHFRASEVEWDPTGRYVVTGVSSWKVKEDTGFNMYTFQGRIIKRTILKNFVQFLWRPRPPTLLSEDKQKDIKKNLKKYYPAFEQKDRLRLTRASKELLEKRSQLRETFMEYRNKRIGEWKEQKSRRVMLRGHVDTDNLETEEVDEEVVEFLVKEEITLLE
The following text describes a protein:
Function:
Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of host immune response. Phosphorylates UL31 and UL34, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. In turn, facilitates nuclear pore impairment and capsid release through impaired nuclear envelope. Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface. Promotes virus intracellular spread by restructuring host cell cytoskeleton. Blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing. Strongly inhibits TCR-activated signal transduction in T-cells by reducing the ubiquitination of LAT and TRAF6, leading to a suboptimal activation of LAT. Subverts host antiviral innate immunity by inhibiting type I interferon production through hyperphosphorylation of beta-catenin/CTNNB1. In addition, phosphorylates the RNA sensor RIGI and the transcription factor IRF3 to prevent the RLR-mediated antiviral signaling pathway. Hyperphosphorylates host RELA and thereby dampens NF-kappa-B signaling. Acts as an immunoevasin partly responsible for inhibition of MR1 expression and antigen presentation in response to bacterial infection.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MACRKFCRVYGGQGRRKEEAVPPETKPSRVFPHGPFYTPAEDACLDSPPPETPKPSHTTPPSEAERLCHLQEILAQMYGNQDYPIEDDPSADAADDVDEDAPDDVAYPEEYAEELFLPGDATGPLIGANDHIPPPCGASPPGIRRRSRDEIGATGFTAEELDAMDREAARAISRGGKPPSTMAKLVTGMGFTIHGALTPGSEGCVFDSSHPDYPQRVIVKAGWYTSTSHEARLLRRLDHPAILPLLDLHVVSGVTCLVLPKYQADLYTYLSRRLNPLGRPQIAAVSRQLLSAVDYIHRQGIIHRDIKTENIFINTPEDICLGDFGAACFVQGSRSSPFPYGIAGTIDTNAPEVLAGDPYTTTVDIWSAGLVIFETAVHNASLFSAPRGPKRGPCDSQITRIIRQAQVHVDEFSPHPESRLTSRYRSRAAGNNRPPYTRPAWTRYYKMDIDVEYLVCKALTFDGALRPSAAELLCLPLFQQK
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Note=Localizes to kinetochores. The NDC80 complex localizes to microtubules.
Sequence:
MFGDRRKTGGLNLNGRASIAITPTKRFTDYTGSTSVRKTDARPSLSQPRVSLFNTKNSSVAPRDVKSLVSLNGSKIYNFLVEYESSDAPSEQLIMKPRGKNDFIACFELIYQHLSKDYEFPRHERIEEEVSQIFKGLGYPYPLKNSYYQPMGSSHGYPHLLDALSWLIDIIRINSAVSEDTQNILFGDFMEQGKAQEKTLNYAWMTSTFRDYTNDRKAAENPSSSYWDDTKHRLRKYFEQSNEFEDMTKTAASALEMLNYECDEIEADKGNEASLKEEISRIRDDIRKAKDYLEQNLHVKQHMEKELAMVKSEQEEKISENEKVQKMVDDLKNKIELQKQIHGLTGKEVRQMNLDNNKDKEVVLEIQSELDRLSKETWKLKDEDFFKEQKSKFIHLAEQIMKILSGLNIQMNLEPLRAPTNERDLKDYWETLNKIWVPEISRQLHQRKLELETEQSRFSNKAVTAEERIQIQSETLCEAKKNEAREERIRRNERDSWKDARKHIEQRYEQLLNEKEVLLKQMKLDGSLEKEIEDETARMSATGEEHIQKRSQLEAGIRQILDLMVVEIAEIENKKIGFHVQCAGIEKAVL
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
CLNQCTYCKTKHARGDLGSYPPEEIVNRAKQAFNEGVVEMWLTSEDTGAYGKDIGVTLPELLWQLVKVIPEGGRMRIGMTNPPYILEHLEEMAKILNHPRVYSFLHVPVQSASTNVLADMKREYIAEDFEHVVNYLRQRVPDLTIATDLICGFPTETEDDFQKTLDLVKKYKFPSLFINQFYPRPGTPAARMKRLPTEEVSL
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MARKLSCRNFAGILVLFSVLGAASFGQEMAPPPFLDTDQSELTVDPGDSLTVTCKGRAPLSWSHPENFGADTASKISIEVLGNGTMKGEYASILTIRNMTSSDTGRYRCYYSDTLPSDIEDSYNAASVYAFVKEASQLFVMMTPMNVLTTQKYRPVTIKCLVTDPEAEVTLWTKTPEKQIIIDGSEITYDKTMGFTLYNPTPRNNGPHMCKATVGNTTVESQTFYLFYFGEAQMPYPKLTTNSPLVTVGETFRLKCEVRGPLDGLLFFNWSLPGADVIGGGIIQNDSKKEEDSGTERYMLFTSVLTVREATVANGGEYVCHARNRAGSASDKIRVNVLESGFIHVECADGNTTQAMVGTRHKIICSINAYPEQVQLTWYKDGHKINKSDSNFLIKARDQRLNILNVAPEHAGIYTLEARNRDVAVNSSVQLLVYMKPTVQIEKTSPHFQMKGEKSVLTCTSEGLPEPTFSWFWKPCGGENPLRCEPSLQAAWQVFSLRNHPNEPLQLQQEMSSDTDGTKVYTSRLTLINPTQNGFYMCTATNRYGNSSAMAEFLVTDVPNGFGVQFDLLDKVEGDEDITFSCQANKFKFTSPTWHRQYPDNVTEAVPTSAIKTKHTEYSNMVVLTLGRVEVEDAGKYVCMAESREDGELIKAETFLYVEAMVAPTMTVGLWDRTVDASNTTSMSLTCLADGVPSPEIRWFHDGEAVLGDVAGIQLEAGGERLVVERISAEDAGIYTCTAVNRAGSVSSNGTVTIEGLPSAVQGLMSTDQKIILGCLLVVLAVVCAVIVLLAWKLHKRRKLYQYIYKLDPDLPIDEQTELLPYNSKWEFSRERMKIGKTLGRGAFGQVMEATAFGIEKDKQCSTVAVKMLKDDASSNEVKALMDELKILIHIGQHLNIVNLLGACTKDGPLYVIVECCKYGNLSNYLRGKRKGFVETKDQLARSNSSSGYDNCRYVDSPNGKCLRTVSKEGIMNYDYTCDDGEPLTLEDLVSYSYQVARGMEYLASKKCIHRDLAARNVLLAKHNVVKICDFGLARDVYCNPEYVKMGNAPLPVKWMAPESIFDRSYTIQSDVWSYGVLLWEIFELGGSPYPGVQINEDFFDKLRQGFRMRQPKHASDDLYQMMLTCWRLEPTERPTFTDLAESMSSQLEATAEQEYLDLSPEIHDDEDSGIPSSPTETDSFLPTFPTDEERRTSRPASGNYDNSRPERHSYGDIVDEEEAVKILMDHPGQRASYHSDAKALPNVSLGVRKGQGSSKSNDSVSSSDSHNSSGFHSYDEAPPDYNTVVTTDV