lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor that regulates ribosomal protein (RP) and ribosome biogenesis (Ribi) gene expression in response to nutrients and stress. Promotes RP gene expression under optimal growth conditions. Leaves the nucleus upon environmental challenges, resulting in a down-regulation of RP gene transcription. The effect of the environmental cues on SFP1 localization is mediated through the TOR pathway. Also regulates the expression of genes involved in the G2/M transition during the mitotic cell cycle and the DNA-damage response. Required for carbon-source modulation of cell size.
Miscellaneous:
MISCELLANEOUS: [ISP+] is the prion form of SFP1. [ISP+] is the result of a conformational change of the cellular SFP1 protein that becomes self-propagating and infectious. This conformational change generates a form of SFP1 that assembles into amyloid fibrils. [ISP+]-aggregates accumulate in the nucleus, and results in significantly larger cell size and increased drug resistance. [ISP+] can be cured by GdnHCl. It is speculated that prion properties of transcription factors may generate an optimized phenotypic heterogeneity that buffers yeast populations against diverse environmental insults; MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nuclear under optimal growth conditions. Leaves the nucleus in response to stress or changes in nutrient availability. The [ISP+] aggregates appear to be nuclear.
Domain:
The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
Sequence:
MDFTTMTMASNMATSTTTTATSAHASINSSSNFNIDIDSNQNTPSILINNNSDSSNGKNTDFNGVNNIHQKNIMNNTNNVHLYSPNIMDQTLLTPQDIAKLRRESIAHSQGMGGVSWGSISVGSWLRDEIISRRNSIVPASANGAASAAASATTTATNTLQIQQPTKRPSVSNPPYHRGYSISPQIAYTAYLPNLEKQYCKDYSCCGLSLPGLHDLLRHYEEAHISTSPNTTNMSQIPMNSAGNTSSSVRMTNNTSSANYNLQNNMAANTKNAGHKTNTMQAHSSNATNNTSINNMHANLQSNMDSNSTIRQSQHPHHQQNIIQQQLQSNSVNHTSGAVPTPSVMGSATASSTTANPNVISITGAPNSGLSMANHSQQLHLNGNLVDAVSTNDVFLRTSNSPSRHVPHNKQINSNNNSGININNNTSHNSNINMGSKNAMVNRPHTFNNYSLNKTSRNPIQHQSRKIDPHQTDLSPLVLVQDIDLSFMDDDILGPSNHNSMNSVVNPTTGSHNYNTFHSSVHAKSSQNMVEDQDIDDIDDDDDVDDDDDDDDDDDTENGSSSNGKSVHNNNYKMPQQAYIDDPARRLYVMDHEEQKPFKCPVIGCEKTYKNQNGLKYHRLHGHQNQKLHENPDGTFSVIDPDSTDSFGDGMGSAKDKPYRCEVCGKRYKNLNGLKYHRGHSTH
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor pep1/vps10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSQHSTDDLMNSHVFSGGFSTLDDKGFQDVPIHTDMPGSISVEPSSEDANVGSVNGNINETPVFEADRLIAEATMNPSAASSTTGENSISQTGSGPFLRIRIVDIEAENSKDPVIKMNVQTTLPAYRSKLYKNVRRTHAEFKKFAKYLISTHPECLIPAVPEAKTSVSSGIKEDLIYLKSGLQSWLNYVSTNPNLLYDPELQLFVESDYGYSPLINTGNPTSGLKRKALKQFPLPPDPCQALANLRPIVKSFYKNAKDAEIKLEKLVNRKQSLALTHADLGQSLIDYSVEEQHNGLANALNRVGKMLQAISDVRIMQSSKQLVTLADSLCYASDNAFVVKEILSNRHILMRDLISSKNQTNSYLSAANRLQDSPKISKARTDDALQALEVARVHEKLLSDKVDFVTLNLVKESKTYTKKTSVSLQKAIREYVEKEAYYERRLLSIMESIRPHIRNIDPFGGLSRLGREEYPRRLSNPPPSQKTNQDAWTNRKRPGYSSSFDGSSQSTFNPSNNDGAHNTSENADELVEPPIGNERLDPKSVANLLNAI
The following text describes a protein:
Function:
Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
Subcellular Localization:
Vacuole.
Sequence:
MASFVFVISLLLLSFSSAVFSDDASFQKLPVPDKRSGPESFAFDSTGGFYTGVSGGKILKYVPGKGYVDFAQITDSSNSAWCNGALGTAFAGKCGRPAGIALNSKTGDLYVADAPLGLHVISPAGGLATKLADSVDGKPFKFLDGLDVDPTTGVVYFTSFSSKFGPREVLIAVGLKDASGKLFKYDPATKAVTELMEGLSGAAGCAVSSDGSFVLVSEFIKSNIKKYWIKGPKAGTIEDFSSLVSNPDNIRRVGSTGNFWVASVVNKVVMPTDPRAVKLDANGKVLQTIFLKNEFGNTLLSEVNEFNGHLYIGTLTGPFAGVMKL
The following text describes a protein:
Function:
Structural component of the gap junctions and the hemichannels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKLLPYSLLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITERERREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHLLILLLSVAPISYLCTYYATQKQNEFTCALGASPDGPAAGGTAVRVSCKLPSVQLQRIVAGVDIVLLCAMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDAGVQTVDPSANPAEPEGTAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPVRRKTATDTLIAPLLDAGARAAHHYKGGGGDPGPVPDKKHARHFSLDVHPYILGTKKAKPEAGPATTLPTSRSQEGGFLSQAEECALGLAAAPTKDAPHPEKEILYPAEPARAALPPGGPFHVCSPPAAPATAPLSPASLGKADPLAILSRNATHPLLHISTLYEAREEEDGGPRAPPDVGSLIAIPPPQQILIATFDEPRTVVSTVEF
The following text describes a protein:
Function:
Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
Subcellular Localization:
Nucleus.
Sequence:
MATYPCQLCGKTFLTLEKFTIHNYSHSRERPYKCLQPDCGKAFISRYKLMRHMATHSPQKSHQCAHCEKTFNRKDHLKNHLQTHDPNKMAFGCEECGKKYNTMLGYKRHLALHAASSGDLTCGVCALELGSTEVLLDHLKAHAEEKPPSGTKEKKHQCDHCERCFYTRKDVRRHLVVHTGCKDFLCQFCAQRFGRKDHLTRHTKKTHSQELMKESLQSGDLLSTFHSISPQFQLKAAPLSPYPLGAPAQNGLASSLPAEVHSHPHNPSDQTSQPVQPLPEPLAPLHPVTSPSSPPPPLQNHKYNTSSTSYSPLASLPLKTDTKGFCNINLLEDLPLQEPQSPHKLTPGFDLAKGSAGKVNLPKELPADAVNLTIPASLDISPLLGFWQLPPPATQNAFGNSTLTLGPGESLPHRLGCLGQQQQDPSLAMSTMSLGQLPLPPIPHVFPAGTGSAILPHFHHAFR
The following text describes a protein:
Function:
Probable transcriptional activator.
Subcellular Localization:
Nucleus.
Sequence:
MDEDGLELQPQEPNSFFDTTGADATHMDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTSESIHVSDIGHVEHVVHDSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANGIPVDQQEDDKGNCEDYLMISLDDAGKIEHDGSSGMTMDAESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNNSIRVPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAAHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Sequence:
MEQDLSKLDVTKLHPLSPEVISRQATINIGTIGHVAHGKSTVMKAISGVQTVRFKNEPEHNITIKLGYANAKIYKCEDDRCPQPMAYGRGKEDSPLCDVPGFENTRMKLPRHVSFVDCPGHDILMATMLNGAAIMDGALLLIAANESCPQPQTFEHLAANKIDLIQESAAMNQHEAIQKFIQGTIAEGAPVVPISAQLEYNIDVICEYIVKKIPIPERNFTSPPNMIVIRSFDQSNASLQGVLRVNQKIEVRPGIVMKDENGNIKCTPIYSRIVSLYAEQNELQFAVPGGLIGVGTTMDPTLTRADRLVGQVLGEVGSLPDVYVELEAGKVSKLTKGEILMLNIGSMSTGARVLAVKNDLAKLQLTAPVCMSRGEKVALSRHVEKHWRLIGWGQIQAGMTLEVPPCPL
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSVIRHINPGLTQFIADLRNARAREMEEKRVNQELANIRQKFTDPNLSGYQKKKYVGKLLYIYILGYKVDFGHLECVKLINSTKLSEKQMGYIALSVLINEDHELVHMVINSVQKDLDGMDEMHNCLALHLVATVGSEMMGSELNHDVYKLLISPTSSTFVRKKASLALLRLFRKNPNIVEPQWYDRIIALIDDPDLGVATSVCSLAIALVQHDPEACATSHIRVVRRLYDLCVNNQAPRDYIYYGVQSPWLLVKMLKLLQYYPPPDAANETTTDMLRQTVLETVDKCSQPAQSSQQSNAQHAVLFEAINLCIHMDMAPDAKLLSILGDFISSKETNLRYLALTALARLAARYEVSSQMSENSALPVKKFLITVLGNLKDKDISIRRKSLDVLYCVCDSSNVKTIVAELLRYLVTADFAIREEMVIKIAVLVEKYATEYKWYVDISLKLIAVAGAHVSEEVWQRVVQIVVNNESLQQYASQTLNTYLAQPQCQECMVKTGAYVLGEYGDLLTEVQPIQLFYNLHSHFRQVSAPTKAMLLSTYIKLANMFPDIKPHISRVLTAYTSSADSEIQQRAIEYVSIIQKPELLKTICDEMPPFEGRTSALLSRLHARELTSQDQRSWGLGKSGKSEVDAIRSKSIMRKNSQISSSNRSDSASPFGDENNVTTGNKTTPPPPPSRGVSHSGLSPNWDLGFYDLCIKDEGTFFKDPVMQVGLKSEYRKNLGCVILYFVNNSGTKISSLSCEITNKEPDNLTVSTKNFPDSSIEPNKQTQQVIILNCHKPFTSSPTIKITYMAGTLKVLHLKLPIVISKFMTASQVSTGDFQNRWNQLADKESRRIFKPQDISKSANPAHNLKVMKGFGWSIDAQQSTRDAIYGAGVLYTSVSGNFGLLGCLQKLQGNQFSITIRGTNAVLPAIVGKCMSDYYQDIM
The following text describes a protein:
Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs) (By similarity). Plays an important role in the proper development of cranial nerves by facilitating the secretion of HBEGF.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAFTFAAFCYMLTLVLCASLIFFVIWHIIAFDELRTDFKNPIDQGNPARARERLKNIERICCLLRKLVVPEYCIHGLFCLMFLCAAEWVTLGLNLPLLLYHLWRYFHRPSDGSEGLFDAVSIMDADILGYCQKEAWCKLAFYLLSFFYYLYSMVYTLVSF
The following text describes a protein:
Function:
Involved in protein export.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNRKLKKILLNWKVLLLIIFLIGSIGSLYTRGLTFGIDISGGVALIAQTEEPVDSKTMELVVDSLQKRLNTFGLRDISVEGQGNSIVVVKVANVSSTEEANQLKQVIESQGVFFMEFNGVVFGTGKDITYVGPYEIKSDNSWAVPFRISKSAAEKFAELAKGKAGWPVDMFLDPPINSLLVVPQDVFMTMNGTAFNAGAPDAPPLAARIEKALNITTIMYTNQSATELKEMANGRAIVLAGVPRELYDGLKDMNVSVKYIPSEPSADTTSFVKEILGLYGPYSLGEGLANGVPQTDVQITGRASNRVEAEREAKTVYTVLKSGSLPVKLKVISMEFISPKLGQDFKKQALYAGLAALVAVLLIVYFHYRNWKIAIPVASTSLFEVIIILGIAALIKWNLDLPSIAGIIAAIGTGVDQQVVITDELLGGERSTRITRRAGALKRIGRAFFIIFASAATTIAAMSFLLVYFVGTLKGFAVTTIIGVLIGIFVTRPAYAEVAKYLIGEE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MITFHTIEQAGKTIHSPCVVTLGNFDGIHLGHQALLDQVLKVSQTTGLSSCVVTYDPNPAIVLGKKAGMKILMSLEDKEEWIRQKGIDFLVVLPFNTELAEMNAELFLEEILLKQLKAKNIIIGFNHCFGKQRRGNYELLKEYSEKLKYSVKKVDPVYLNDTKLSSSYVRRLITEGNVKEAFHCLNRSYSISGIVVGGHKRGRDIGFPTANVKPNMDILLPGIGVYAGLTQVEGIEYPSMINIGRNPTFGINSLTLESHIFDFQKDIYDQTVRIYFKEKIRDEIKFSSVETLISQLKQDEILTRNILKSTIGKNSAHF
The following text describes a protein:
Function:
Acyltransferase that mediates the acylation of lysophospholipids to produce phospholipids (glycerophospholipids). Highest activity with lysophosphatidylinositol (1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) or LPI) producing phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) or PI) (LPIAT activity), but also converts lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity), lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity), and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) producing phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Has a preference for unsaturated fatty acid arachidonoyl-CoA ((5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA). Glycerophospholipids are important structural and functional components of cellular membrane, acyl-chain remodeling regulates the molecular species distribution of glycerophospholipids which can affect membrane fluidity and curvature.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSIDDVIYVICLLGCIGAGSYVKKIADEGQRKLVSTGLGVLVVVIVSGLHSLHCFVSLALGTAAVLLVHPSKGHLVTFAVMFGYLVFFRIFDFYFGIPGHTNMIQMILTLKVSGIAFEKTAAWKRLQAHDEQKKNDQRDVHQESPIEITDYDVELQSLSAAEILHYSFNYIGVLTGPYYRYRTYRDYFEMPFKTYAPTVEATLEKLKYAVFYCALYLATNYMWPLDYALSDEFFNDRSFVYRLLYVWPTFFTFRARIYTGLTLSECVCTMAGFGAYPDESDPNNGEGPRKRYQHLKRDADKHTYNFTTIVNTRVLEVERCWTFREGMKHWNVCVQYWLAVNVYKLFPSKKYRTGATLLCSAYWHGFRPGHYFCIMGAPFYVSLEDMWDKLVRKSATGTSRRVIDVIFWIFKWFAFSYLGEAFLLSSFGNIWRFYSSVYHIGYISWAAMTALGFYLTSQRKAAERRKKRAAEKAAGGDGIAAAIEKEKAQ
The following text describes a protein:
Function:
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
Subcellular Localization:
Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Sequence:
MRASTHSWLLLVVVLSLSSFTVNAVILEGLIPPRSHLAPSTFQQPFALSSYLQKLFGTSLRALYGAEQNRQTSVKTFGLREAYHQGIGDKAHERARATFDFRITANDVQADQANIDFIPAIRTVRQRITRAKDPKKYVEVRGQSYRDAMCAASTELDWEDVDVEAPDVTERTTVLAFAKMASAAYKNDTSDWDGIGGFDPTNSFGWEGDGIRGHIFTTHDNDTIVVALKGTSNVFLGGGDTARRDKTNDNLLFSCCCARVSWSWSTVCDCYQGHGDQCGQTCVERALIEKSLYYPAITDLFNNVSYAYPDSQIWITGHSLGGALSSLLGMTFGVPTVTFQAPGERMAAMRLHLPLPPAKHADESPVAALPIVHVYNNADPIATGTCNGAASVCSNFGYAMESKCHSGKSIVYDTVGKLGWSMTINAHRINTLVDDVLTEDWSEKVRKKKAKLRSIGSRGGQISTRGWRWPWHRGDSADDDGDSDEDTDEDDKLAVPKARSEERCQDCTNWHFTDETL
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). The physiological function of RAB42 remains undefined (Probable).
Subcellular Localization:
Membrane; Lipid-anchor.
Domain:
Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MEAEGCRYQFRVALLGDAAVGKTSLLRSYVAGAPGAPEPEPEPEPTVGAECYRRALQLRAGPRVKLQLWDTAGHERFRCITRSFYRNVVGVLLVFDVTNRKSFEHIQDWHQEVMATQGPDKVIFLLVGHKSDLQSTRCVSAQEAEELAASLGMAFVETSVKNNCNVDLAFDTLADAIQQALQQGDIKLEEGWGGVRLIHKTQIPRSPSRKQHSGPCQC
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MKGTNAKKVVRGEWTPMGSLCYVLGVLLMLVVAVTLCSIRTPRNQSSLMERFMDFQLPLKKNLAEDVLLSSADIDCASLGSPLKSIPSDEQYHPKNTLDAEVCTSKYMQHCYWNATRKPPPPQFLQALREYEALHQRCVGNHNLTELFVAGKVPEGCKYLVWKEQDGKGNQIMSLVSAFIYSLLTKRTLLTMPSLGHVDGSLHHLLCEPFPGSSWKLPPDFPLDAMLQQTDVQWDYFHKVDNLTKNGSESYLDASSTISPSRLYITLSNYNVPDHEDRRFFCPAEQTLLSRIPWLVLKSNNYIAAGFYFLPEYRQALNQLFPDRAMFLHAGRYLLNPRNDIWGRITRFYDGYLLNADKKIGIQVRSWKPEYNPILSEHILRCATLNNILPNVTQEDTAPPTKTPPERVTVLMTGLVAQYHHDVREKYLRNANVRGDSISVLSPSSEGVQQTGDVEHDKKALADMWLLSFMDDLVSSPKSTFGYVAHGLAGITPYVFVRWGFEDYTQYNGCERSNLAGPCYIDTPHGQECPLDPPGTRIGDPNAAVPEIQHCRNQWGVGVFPG
The following text describes a protein:
Function:
Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.
Miscellaneous:
MISCELLANEOUS: To study the function of the orphan receptor CEACAM4 chimeric proteins containing the extracellular bacteria-binding domain of CEACAM3 and the transmembrane and cytoplasmic part of CEACAM4 has been used.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGPPSAAPRGGHRPWQGLLITASLLTFWHPPTTVQFTIEALPSSAAEGKDVLLLACNISETIQAYYWHKGKTAEGSPLIAGYITDIQANIPGAAYSGRETVYPNGSLLFQNITLEDAGSYTLRTINASYDSDQATGQLHVHQNNVPGLPVGAVAGIVTGVLVGVALVAALVCFLLLSRTGRASIQRDLREQPPPASTPGHGPSHRSTFSAPLPSPRTATPIYEELLYSDANIYCQIDHKADVVS
The following text describes a protein:
Function:
Required for targeting of connexins to the plasma membrane.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway.
Sequence:
MDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSDSAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAVTYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKESQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIEGIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDGSENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSDESCLSLDDLAKRIEIAEVVPTEGLVSILKKRNDTVGDHPAQMQHKPSKRRVRFQEIDDSLDQDEVGGGSCILLVLLCIATVFLSVGGTALYCTFGDMESPVCTDFADNMDFYYTKLLQGVAELKHWIYLS
The following text describes a protein:
Function:
A phasin, it attaches to the polyhydroxybutyrate (PHB) granule surface regulating the number and size of PHB granules within a cell. It probably also acts as a regulator affecting the biosynthetic activity of PHB synthase in vivo.
Miscellaneous:
MISCELLANEOUS: Nitrogen-free medium induces chlorosis in Synechocystis, leading to the degradation of the photosynthetic apparatus and concomitant accumulation of cytoplasmic polyhydroxyalkanoic acid (PHA) granules which in this cyanobacterium are composed of PHB.
Subcellular Localization:
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distributed in cytoplasm during photoautotrophic growth, insoluble and associated with polyhydroxybutyrate (PHB) granules under nitrogen starvation.
Domain:
Probably has 2 alpha-helices (resides 3-26 and 39-83); both helices alone target to PHB granules, although helix 2 may be the main anchor. Both helices are required for oligomerization.
Sequence:
MNTQFFEEYQTQLLDWQKKFFSTWMESLPKGTAEIKLTDTFETSLKLQEEMVKSYLEAQEKSATMMIDAQKQFWDNYFQALRQEPVSAN
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHILKFATLIAAAVIATAGADKQSKNRADCTDPCTCMARIDVALNRLEGAMPQTLQKIASNAAYMSELQMAAGSTDAELAKLVQPLLAVAIDVQQDATTDLPTASKTISETLNALTQRKALFEAIKKLSGTYDGSIITKTSGHFGTAQYTAAPIVAVQREPCPKLSGTEEYTYDELNFDHGQGIGLPQLAIELDQACYKNTEGTPCDANDGSDKLKTKIKFGTKHGPAGTSPLANGRFATTVQGTINLSNETAADNKKKLSKAAAADAKLTNIPDLSKRETYTSHPAFSLLVNRLLMSTAPTVEITGQVATATEAFINKNYGSDQEQFKAKIWDKIKTATTVYYENKAKKTKKVSALSGDQKVTALPAAFFKEQKETTTTKKETAEDAPKKTDTEDKKGEKKDGDKTSGESFSSYQTKDACEAVNKDGKKHCGWKRKVIATPKRIKKPAQTVVFSSIKKLALCVAAAFVSILVF
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MEAPQLAPQSSAESQIDGARRNPAHRTVERVGWDLRLAPPPHKRTIQKSAAQERLRRGLLNSEQSSMELLPPVKGGQLRVGVLFECDERCERRLLWASEKGEAGAQTVTEKEETSLEFFYTPSLQTNSNEGEGSLPRKQIKLRFSTEITTVRAIELGNGSEVGFLVESKHAPLVYEISGDENGFKKRFTRTVDFTPGVALAKSNTYDFTLPRSPQNEAVLNGFFGFSNELDWVKPPLQVDGSVFPEAVPPEGSVPPLSPNGDEALYLEPQVDSSILQADLPFDVLWLLNALLQAGLLLGDRLKGEFLELVTLLVATGGEELVVVGLGKLFAQGKRIWDPTAALSRMTADILSLHTLPPRRAPPPPHTVLVYRLVITPCRAFASLPVAEPSNRLLRSYPELSKEGRFLRVSFRDEDGGLLSGGPLKSRERNPPEDGWEPRSAVYDRFSKIDFLFGGRRYRQLATSASQVCGFSFWAFAEEDLPGSVSRDQIRSAMGDFDGIREAAKHAVRPGLVLSTTIPTVTLKEDEVVTLDEVVRHGLSFADGCGRVSPDLAEMVAAKLPGVENPKSVAAFQIRFGGCKGMLQVFPPWAGRNLVGIRPSMDKFQSDHRTIEVISWASAPKPAFLGRQLIQLLEARGIPARVFETLQAEHLRTFDDVMLTGRTTAPLRALVGARSPAAALLAPRPGASSDALSPFQCRVVARMRERHVSELRDRARIYVPDGALVLGVVDELRVLAPGQIFVSLSGRGVVTGRVIVYRNPGLHPGDVRVLRAVDCPELHHVENVVVFSVLGRQRPESVNLTNGDLDGDRYWVFWDQRLVPDTSLPPFKYESSPPMPPEDRNLTVQDDRFFQLKHRREDNLGAICVAHMALCDARPRGANDPDCARLAQMAFDASNFVKSGFSVVLPAELRPRAYPDFMQKRGEESYASQNALGKLFRALDTAEWNRAAFYPADVTHGPAPADEAEFRDVSVSDARLNWARGLKAEYDSSVLELMDTYGLQAQEDLIVGAASFDSAGTELDGAELGEGEAEAEDGDEVTLEDEEGKMTGSDVEPKGRGTCLEDENGDMEVDRLGVTEVGDTIGKMDLGGGRKGRRSETRSRDERTEGEDVMREAPRVGADTSERPEFYPEKSGSRPGVQGRKGGSGSGTRTAQSRKEKTERQERVGAAFEALLAHFRERLDEGPPVSARENEDPSKKPKLEERHLNAAACYQATYGTASAEAEWSGGTAFATIGGIVYGKAEAERIGGTAGDVKLRGFWEVLARPHIVGSDACVNGGFN
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MGCCGCSGGCGSSCGGCGSGCGGCGSGCGGCGSGCGGSGSSCCVPVCCCKPVCCRVPTCSCSSCGKGGCGSSGGSKGGCGSCGGCKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSGCGGCGSSCCVPVCCCKPMCCCVPACSCSSCGKGGCGSCGCSKGACGSCGGSKGGCGSCGGCKGGCGSCGGSKGGCGSGCGGCGSGCGVPVCCCSCSSCGSCAGSKGGCGSSCSQCSCCKPCCCSSGCGSSCCQSSCCKPCCSQSSCCVPVCCQCKI
The following text describes a protein:
Function:
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Plays a role in the regulation of primary cilia length and Hedgehog signaling.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus speckle. Note=Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.
Sequence:
MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKPPGKGTEQNPRQHNELRREETTAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPRPSVSRPPLPPPEVEPQGGKISREPEPEAGSQTKESATVSSPAPMSPTRRRALDHYLTLRSSGWIPDGRGRWIKDENVEFDSDEEEPPDLPLD
The following text describes a protein:
Function:
Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (Mlh1-Pms2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with Mlh3 to form MutL gamma which plays a role in meiosis (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Recruited to chromatin in a MCM9-dependent manner.
Sequence:
MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMTENCLDAKSTNIQVIVREGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQTFEDLAMISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRKKALKNPSEEYGKILEVVGRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELIEVGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESAALKKAIEAVYAAYLPKNTHPFLYLILEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEAVKSTTGIASSSTSGSGDKVHAYQMVRTDSRDQKLDAFMQPVSRRLPSQPQDPVPGNRTEGSPEKAMQKDQEISELPAPMEAAADSASLERESVIGASEVVAPQRHPSSPGSSRKRHPEDSDVEMMENDSRKEMTAACYPRRRIINLTSVLSLQEEINDRGHETLREMLRNHTFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLPEPAPLFDFAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAKMLADYFSVEIDEEGNLIGLPLLIDSYVPPLEGLPIFILRLATEVNWDEEECFESLSKECAVFYSIRKQYILEESALSGQQSDMPGSPSKPWKWTVEHIIYKAFRSHLLPPKHFTEDGNVLQLANLPDLCKVFERC
The following text describes a protein:
Function:
May play a role during early embryonic development. Probably involved in pre-mRNA splicing (By similarity).
Subcellular Localization:
Nucleus speckle.
Sequence:
MPKRTTHTYSSEDAAPDGPDSDLFVYYCKHCGSHVLITDTQLQKMPKRKTDRSNVLDKKTHLARLNVSEGGKVLLKRGEGKMERQFRMNCIGCELFVCYRAEENLETASFIYIVDGALSAVAAETNPQDAPVPPCISQLDGGLVQVAIEVEDRAQRSAITRVNADDVRVTVAAPAARGEANNELLEFMGRVLGLRLSQMTLQRGWNSKSKLLVVEDLSARQVYEKLLEAVVP