The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; (Microbial infection) Binds to and is probably the functional receptor for B.thuringiensis subsp. israelensis (Bti) insecticidal toxin Cry4B. Trichoplusia ni insect cells stably transfected with this protein become suspectible to Cry4B; cells undergo oncosis, they bleb and ruffle after 20-40 minutes, swell after 40-60 minutes and lyse after 90 minutes. Following toxin treatment in the T.in insect system levels of intracellular 3',5'-cyclic AMP (cAMP) rise 12.5-fold; EDTA but not EGTA pretreatment prevents cAMP increase. Inorganic phosphate also rises 3.4-fold after toxin treatment.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Note=Found in microvilli membranes in the posterior midgut of early 4th instar larvae (at protein level).
Domain:
Three calcium ions are usually bound at the interface of each cadherin domain and strengthen the connections, imparting a strong curvature to the full-length ectodomain; (Microbial infection) A membrane-proximal extracellular domain fragment (residues 1358-1569, called CR11-MPED) when expressed and mixed with activated Cry4B toxin from Bti enhances the toxicity from 20% mortality to 92% mortality. The CR11-MPED fragment does not bind Cry4B as well as purified AgCad1/BT-r3. Another peptide (residues 1570-1735) does not synergize toxicity. A larger fragment (residues 874-1569, called EC7-11:MPED) also binds Cry4B; binding leads to cell death.
Sequence:
MKCVASKFNMWLHLGWLLGLLLVLLPLVRCQGWGEPRFETGNVENISLAAYNEAQLQQDVWMVEEMDAPFVLLYINYQGPSEPTIRESPADLDARLQLSEGGRWSIVINRRQDYEVHQRSSLILLAVESTAIPYAIVVNLVNVLDNAPVMTAQGSCEIEELRGDFVTDCLFNVYHADGFEENGIGNSSTNELSFEIGDVAGARDHFTYVPSTVTPSQPIYNKLFNLKVLKQLDYTENAIFNFITTVYDLDRTHSFKMSTIVQVRNVDSRPPIFSRPFTSERIMEKEPFYATVIAIDRDTGLNKPICYELTALVPEYQKYFEIGQTDGKLTVHPIDRDAEQNELYTFTIVAYKCHNRLLNTSSEGAIILLDKNDNIPEIYMKPLELEFWENTIMELPFDELVIHDRDLGENARYEVRLAETVAGVQQTTDSFTIIPGNGYQRVSFTININNATSLDYELPERQTFVLHVTAHEPIEPTHESTQPITIRLKNWNDEVPKFGRDEYQISVPETIGAGELLATVTVTDRDIDDGIRLFALGRLAESLSVTELPVSAEPETNLPLYGFEIATKVGDIFDYDIAKEVIVQLQAEDTLRTAKQESLHQIFSQLTITVIDVNNKPPQITLPRGTMHILENSVPDSAVIIGEEQIAQIIGTDPDTEAELEFSIDWSNSYGTKSGIRAKAETYENCFYIHEEKVNRQRTIGTIRVNPTFPLDVDHEMYDTLFLVIRLVDRNQTILPNTVETVVAIQIDDENDNAPYFDNSTLTVVRSVKERSDSGVTIGNIIAHDIDGPGNNEITFAMEPIDPAHKGWMNIDDNGIVRVEGNRSIDCDIPPIDKVLQNVTISDWKWSNWHVFEIVLMDTNNKQPYHDPFPNDGQVYQFEKIPSNTAIVRVEGKDQDRDVPYHTVSYEINYRDFPQLQRYFEVDSTGRVYVKENNDLLDRDAGLESIMINIVMLDNAGGYDIQNRVSTNINLTLLDINDHTPKLPELAADELKVSENAKQGYIVKTPFAALDLDDKRTPNAKINYYIEEMTPELETPLFSLENIDEYNAVLRVAQDLKGFYGTWTLKIKACDRGSEYEPIIPLTEEPKDNCETRDYELTVEPFNYNTPSITYPSRSAQLRLKYESLQNGRPLVETNGSPLPKFEAIDDDGGIYGDVTFSLTSTNDGEQDHEVFRVDKVDNKTGLLVLENSLAVQPFPKNYSITVIARDGGDRQSEAAIHVVFINMTGEPAFLEPTFDTDFTENEEGRDERRQLPFAEDPKNAGLPPGAETNVYYFIDKTYGNASHLFQLDRVSNVLQLAQLLDREEIPTHEIRIVATNNENGPPDTVLESSPSLLVVRIKVNDVNDNPPVFQQRLYAAGITTNDRVPKALFRVYAEDPDEDEIIRYELVNGTAVGENLQTDGLPFRLHPDSGELTLTSKVQPNQNGYYQLTLIAFDRDDTHNDTVPAKVYIVSESNRVTFVFLNSVEEIDQPDVRKFLAQELTGAYEMECNIDDIDQTTASDGRQAGGSSSALTDVRTHFIQDNQAVEASRIQQRSSNRTFVTVLKTTLRTRGLSLQDVPPLATEALTEADETLQIILIVVSAALAVLCVILFVAFFIKIRSLNRQLKALSATDFGSISSELNGKPTRNVPTTNIFSIEGSNPVLNDNEFRDRMGGSGGGVYDDLSLQSEESDFNDVDRDIFAPKRKESLNPALLEHIRQRSLNPMANGTDKSNDGAPTSNHKKLDETDDELSHRF