lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in DNA replication and thus regulate cell proliferation.
Sequence:
MNLSEKYRPKSFHELVGQSEVAQSLLDTILKGKIAPIYLFHGPRGTGKTTAARIFAAALNCQSCKEQWPCGCCQECVLVFSGRSRDVTELDASETNHKDALKVLSESALVPTSSCYKIFIIDECQLLQRNIWSAIYKSIEDLSQQVVFIMITSDPDKLPSGTLSWCQRYHFLNVKSDDIVGRLKKICLEEKLEFEEDALIFLATESNGSLRDAITTLDQLALLGKGIITSLAYELMGIISNDELLDLLHLALSSDTSGTVRRARELISSGIDPMQLTSQLAKLIMDILSGGCQLEPSRFIAEADKEKLKHGLKILVETEKQLRTSKDQSTWLTAALLQFNTGESLPPTNMNPLEAPEKVSYSRDDGPPTVASPKESLKSAITVCNHHISSSKSHYDAARELEDIWRRTIENCQSSSLKRFLWKEGRLSSVHVCEGLAVAELEFCHPDHVSRAEESWELIIGSLQTVLGCKVDIKISLVPINRRAKKKSSISLFCCTGRKQQTSDLTVTNKKDSLLPGTKEETIEFCSSHHKEDLCIKQQLHFNTMYSSNSFDQKVVNTNASNGYALVTGNTMVSRTVQDGLSKECKEETDPSMEVCEGGQYVNIQGTEDQPSCFCCTLKFSRSFSANAAHATTLRIKQLDKLNLFNSKKSSSEENFCTDDPYLFCSDTNEQDTYNTEEDNGPSTGSSLCSRLYCCRASMPVEKAGPKRQQDGRPRLVGSLWPCAEQASPETTTAEQHSPALKQKAKRRP
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MKSVIFAATIAAASAFAPAQVAKTTTSLNAFEDELGAQAPLGFFDPFGMLSGDCTQERFDRLRYVEIKHGRIAQLAFLGQVVTRAGIHLPGSINYAGDSFDSFPNGVAALFGPNSIPTAGLVQIISFIGILECAFMRDVPGTGNEHVGDFRNGYIDFGWDEFDEETKLSKRAIELNNGRAAMMGILGLMVHEEIIPLGYDADLPIIGHLQ
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MLFPEEDAGELKKWIIKRLENTSDADADVLADYVLALLRHDGDVNTVRQLCLAEIPDFLKEDTSIFVRDVFDALQYKTYLSGGPPRRPSQPFAPPTGPSGAPFNNLNMGAPMGHPNGSRKRTYDGRGDGDSQMYMGGDQNARAYKQPRRGGGAGRGNFDNFNNGRGGFQGRPQHMPMPNAPFPNMQGMPGSPTGLPPLDPNNPMAALLAMQQAMDAMGLPLPQGMPGFPPNGSPQNRGQAGPMSQRKQRCRDYDQKGFCARGNTCMYEHGQDSIYVPGGAGKPTDEYDPSNASLMTGKLNQNDNGQGPASFGGLDNNRGGMGRGRGHSMGRGGSQMHAGRGGRRAEFSSDRPNFNTNNTTIVIEQIPEEKFSEEAVREFFSEFGNIKEVDMRPYKRLALVKYDDWNAANTAYSSPKVIFDNRFVKVYWYTNPEALPKPPGNASSNGTTNNGTHGPFPTRETDEPQIDIEEFTKKQQEVQRVHEEKMKKKQEMEATRKELERRQEELLKNQAEEKRKLMEKLAAKTGKSASPGVKAEEGSPAPKTSSQTEALKKQLAALEAEAQSLGLPNLDNPLSDDTWGGRGRGRGGYRGRGTFAPRGFRGGYRGRGGAPFGGSAPARYTLDNRTKKIAVSGADFTNPQIDESLREHLLGIGEYTELTNTANGCHITFKDRHTAEKFMFGLQNGEIPSVGKVDLSWIQTPLPPVTLSNTQNSSGSSRTESDVKIEGGMEGDAMAQDSPSMNMSGTGADRDMQENIDYDVAGDDDWGVQ
The following text describes a protein:
Function:
Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Required for the activation of genes such as Antp, Ubx and Eve. Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins. Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. Acts as an essential coactivator for Zeste, which recruits the whole complex to specific genes. In contrast, it acts as a corepressor for Wg target genes, possibly via an interaction with Pan and Gro. It also acts as a negative regulator for proneural achaete-scute, when it is directly recruited by Pan and Chi. Also represses E2f activation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
YLAAADSAMARTVALQSPCISYLVAFIEQAEQTALGVANQHGINYLRENPDSMGTSLDMLRRAAGTLLHLAKHPDNRSLFMQQEQRLLGLVMSHILDQQVALIISRVLYQVSRGTGPIHSVEFRLLQQRQQQQLRPASAEKQAASAGGSAPVKAEAASTETSSTEAKPAPAATTAVVNDENSNSSQQLPPAATFNDVSNSSTNSNSCGTVSSNQTNXXXXNSSHSSSAISSQSAITVTAPSAPATGATSAXXXAITSDQQQVSKVAAAAAAAAALSNASAAAAAAAAAAAASVGPPTSSSVSAGAAVAQPAAPPPTNAGTTTAV
The following text describes a protein:
Function:
Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity).
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MDKDNQALDELPMLTGSKHANKRLFAAFMIFGLLNNVLYVIILSAALDLVSADTPKGVVALFNIFPALITKVVWPLLSNGKIRYTRRVGFCTICSWFGIITIALSSSLSPRLLGISLASLSSGMGELTFLQLTTTLPTEATSKTALGAWSSGTGFAGVAGAGIWWLLRGLGVKGGLGLSSFLPLFFPITYKYILPPFSHLEASSDSSPYQRLPMSSSLSNNNNFRPPAILISVPSSEYVPQHTPLLSSGFIDRDRDRNRDGEELTDGDKRLMGMRASRLTTQEKMKLLRPLVVRYMLPLCAVYVEEYVINSGVAPTLVFPLPTYGLWSWLFKSPRDYYPFWSLTYQTFVFLSRSSLSLGLPPIPKRLLPLPAIIQFLVLSLLFLQAKTFFFSSPAYTPPADGDGGVDRSITIVFLLICLEGLCGGSGYVNTFYHVGREGSVSENYDADGDNEMGGDRRTVNVTEMEKKAMEREFRIGAVGAADSTGILFASLISMPLEIALCRSQVDQGRTMCREL
The following text describes a protein:
Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons and sensitivity to CO2 levels. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and together with tax-6 inhibitor rcan-1 regulates thermotaxis in AFD neurons. Regulates expression of rcan-1. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. Plays a role in egg-laying, body-size, fertility, growth, movement and cuticle development. Negatively regulates lifespan. Promotes transcription activator crtc-1 nuclear localization, probably by dephosphorylating crtc-1 and thereby negatively regulates lifespan. Regulates expression of chemoreceptor srt-2 in AWC neurons probably downstream of Ser/Thr kinase kin-29. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Plays a role in several endocytic processes including in coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle recycling. May negatively regulate excitatory GABA receptor exp-1 during enteric muscle contraction. May negatively regulate autophagy.
Subcellular Localization:
Perikaryon. Cell projection, cilium. Cytoplasm; [Isoform a]: Perikaryon. Cell projection, dendrite. Cell projection, axon. Cell projection, cilium. Cytoplasm.
Domain:
The autoinhibitory domain prevents access to the catalytic site; The autoinhibitory segment prevents access to the substrate binding site; Possible isomerization of Pro-334 within the SAPNY motif triggers a conformation switch which affects the organization and thus accessibility of the active site and the substrate binding region (PxIxIF motif). The trans- to cis-transition may favor calcineurin A activation and substrate binding. The reverse cis- to trans-transition may be enhanced by peptidyl-prolyl isomerases such as PPIA.
Sequence:
MASTSAGQNSAAKPDTTNTTTTASNNNRERERDLKQFTERFVKTVQFPVSERLTVDQVYDRRTGKPRHEVLRDHFIKEGRIEEEAAIRVIQECSSLFRNEKTMLEIEAPVTVCGDIHGQFYDLMKLFEVGGSPATTKYLFLGDYVDRGYFSIECVLYLWALKICYPTTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDVCMESFDALPLAALMNQQFLCVHGGLSPEIHTLEDIRRIDRFKEPPAFGPMCDLLWSDPLEDFGNERNSEQFSHNSVRGCSYFYSYAACCDFLQHNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVHILNICSDDELMAECDDTFEGGVGSARKEVIRHKIRAIGKMARAFSVLRHESESVLQLKGLNAGGKLPQGALSEGRTGLNAAYRIEQSVAAESGCDSGHLIQSFEEARRLDKINERMPPTMATPPAQSPSQSPIPSRQTTPQPPQNGPSNS
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MIIKRELKTQMIPSLKRCRLSNSVSHSTKKRKSNLGGYYYPLSLLGDISSGIVPGGGPNGFSTREAPSGVSRPPLVPTSRGRIRMLPSRFNDSVLDNWRKDGKNGREGEVERRKEKASSSLKSKQLEARACVVVREREDERVQREGFYGPENFYSGDLVWAKSGRSEPFWPAIVIDPMVQAPELVLRSCIPDSACVVFFGHSGNESERDYAWVRRGMIFPFLDYVARFQEQSELQGCSPGRFQMALEEAFLADQGFMEKLMDDIHTAAGNSSFDDSFHRWSHDLNNNAPSQASVSLPMSSLYIGCETVISFEMAKKMKALTPGDQLLCKPCSRVKKSKHNCGICKRIGNHLDRQTWVKCDGCKVWVHVECDKTSDKHLKGLGETDYYCPTCRAKFNFELSDSEKPKLKLGKGDGGMVLPDKVIVVCSGVEGIYFPSLHLIVCKCGSCGPQKKALSEWERHTGSKVRNWKTSVKVKSSKLPLEEWMMKLGELHANATAANVPKRPSIKQRKQKLRAFLSVHQECYGATNIHDFTSWVCKACQKPSIKRDCCLCPVKGGALKPTDVETLWVHVTCAWFQPEVCFASDEKMEPAVGILSIPSSNFVKICVICKQIHGSCTQCCKCSTYYHAMCASRAGYRMELHSLEKNGRQITNMLSYCAYHRAPDPDTVLIMQTSKDVFSAKGLVQNKKQGGSRLISSIRRDDKESPAEDTVTCDPFSAARCRVYRRNTNTKKRSEEEAIPHHTRGPSHYPSAAIRTLNTFRHVPEEPKSFSSFRERLRHLQASTLWTEMDRVCFGRSGIHGWGLFAKRIIQDGEMVIEYRGEQVRGSIADLREARYRREGKDCYLFKISEEVVVDATDKGNIARLINHSCTPNCYARIMSVGDGESRIVLIAKANIAVGEELTYDYLFDPDEPEEFKVPCLCKAPNCRKFMN
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MELDHDEQHPDRKTVPQVQCCVCGLVIDSNISNMCANCLRAHVDITDDLQREYILIHCPECGRYLQPPKYWARAELESRELLTICLKRIKGLNSSAGSNSNANKAKLVDAKFLWTEPHSKRIKLRLTVQKEIFNNIVIQQACVVEYVVTWQQCTMCQRVATGQPQWDACVQLRQKVNHKKTFLYLEQLILKKRLHENFIRIEGQPDGLDFFFAHKSHAMNFLEFLNKTAPVTRRDAVQLVSHDSKNNTAVQHFTFALDIAPLCREDLILIPYKDYYLKSLGGMGPLVLVHKVFSSIVFMDPRTLRAGEITGALYWKKPFASLQTSRELVDFYVLECQLMPVTNGTYQLGLVTVCLSDEVGKGREWIVQSHLGGVLHPGDLVKGYLLEGRILNNEDLDKNRYKPEQLQDVIIVRKFFPSQRARRNRRLWKLKKLDIVTSQGEATSISGPARRGGASANSGVNEDECEFEDEIERDADLRKEIAIYRMMDEEIAARRGAAATAAGAAENEYEGDDEIPEIALEEMLDELQIDDGAEPAGAEENLMANEDSDNEAVADIHKKVRIE
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MQALAVLLLLSLTLSVSHVEYYSITRDNRILPGVDPEGAASIKLQDRKFEFGYTYAVIKTNPDIPDYEQAYAAGYLEGYTMGPHIYHLMNNVLEDSFDGEFPVEFYTYTQKNLAYIKEQVNVNTSVFWHAVNLTACNWLQGLTHGYTRYANEEKIRPYTIEEFFMYNSVGDWEDLEAVLIVEPTRREKMLQRRRERIELGQHHHCSAAVRMSPDLSDVFFSHDTWTSFGSGFNRAMKHYHFHWDLGESQHQKVSFSSMPGYFSSIDDFYIQSVTSATGRKSNVAVLETTYHTFNTTLYDEFLRTDGSVVLTWMRSQIANMMAFSADQWSEVFNNENSYTYNNMWVSLDYGLFDLLSEATVNMTIEEKKDYILHYGKPLLYVNEVVPGHIKAYDVTEMLLNDGYFFSINTPMDEELFVISGYAAKNDPYWSFNESSRYKIFTRELPKVDNFEDFKLLMRYNDYLNDDASNKDPGQSIASRYDLRDPLLCGRSPSIFGCTDSKATDAKLAAQLAFDVVVGPTRGRDGLLPLFNFSQHPGVPRHGVPDTLPDRWSIYLPMFVEDILQNNWE
The following text describes a protein:
Function:
Serine/tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the OPG144 protein.
Subcellular Localization:
Virion. Host cytoplasm. Note=Approximately 200 molecules of OPG106 are packaged within the virion and are essential for the viability of the virus.
Sequence:
MDKKSLYKYLLLRSTGDMHKAKSPTIMTRVTNNVYLGNYKNAMDAPSSEVKFKYVLNLTMDKYTLPNSNINIIHIPLVDDTTTDISKYFDDVTAFLSKCDQRNEPVLVHCAAGVNRSGAMILAYLMSKNKESLPMLYFLYVYHSMRDLRGAFVENPSFKRQIIEKYVIDKN
The following text describes a protein:
Function:
Major phosphatase responsible with PTP3 for tyrosine dephosphorylation of MAP kinase HOG1 to inactivate its activity. May also be involved in the regulation of MAP kinase FUS3. May be implicated in the ubiquitin-mediated protein degradation.
Miscellaneous:
MISCELLANEOUS: Present with 149 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDRIAQQYRNGKRDNNGNRMASSAISEKGHIQVNQTRTPGQMPVYRGETINLSNLPQNQIKPCKDLDDVNIRRNNSNRHSKILLLDLCAGPNTNSFLGNTNAKDITVLSLPLPSTLVKRSNYPFENLLKNYLGSDEKYIEFTKIIKDYDIFIFSDSFSRISSCLKTTFCLIEKFKKFICHFFPSPYLKFFLLEGSLNDSKAPSLGKNKKNCILPKLDLNLNVNLTSRSTLNLRINIPPPNDSNKIFLQSLKKDLIHYSPNSLQKFFQFNMPADLAPNDTILPNWLKFCSVKENEKVILKKLFNNFETLENFEMQRLEKCLKFKKKPLHQKQLSQKQRGPQSTDDSKLYSLTSLQRQYKSSLKSNIQKNQKLKLIIPKNNTSSSPSPLSSDDTIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSEASTTETKTDKSYPMCPVDAKNHSCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLLFNPQSFITSLEKDVCKPDLIDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQIKNALPC
The following text describes a protein:
Function:
Replicates viral genomic DNA in the late phase of lytic infection, producing long concatemeric DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein (By similarity).
Subcellular Localization:
Host nucleus. Note=the protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.
Sequence:
MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKHKTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVSPRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPEPRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDPLTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSFDIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHSGLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTRLEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAGSVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCLQDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNHYSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGSNSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFASLYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKWVSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRIGRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSTLPEGLETSSGGLNERRVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMICKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSLDEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVIKRLAARSEELPSVGDRVFYVLTAPGVRAAPQGSSDNGDSVTTGVVSRSDAIDGTDDDADGGGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNVLSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
The following text describes a protein:
Function:
Responsible for the transport of C4-dicarboxylates during anaerobic growth. Catalyzes the uptake of fumarate coupled to the export of succinate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEIAMLELLIGLVVTFAVGYFIVKGYKPAGILLTAGILLLILTGILGHKVLPGQMESTGNLLTDAMEYVKYMLQNRGGGLGMQIMLLCGFASYMTHIGANNVVVKQFSKPLSFIKSPYILLVAAYLVACLMSLAVSSATGLGVLLMATLFPMMTAMGISRPAAVAVCASPAAIILSPTSGDVVIAAEKSGLPLHVFAVETVLPVSICAIIVMAAAAYFWNQYLDKKDNTPMEKVDLSEMEVKSPAYYAVLPFLPIIGVFVFNGETLPGITLDIYTIVVLSIFIGVLVDYITKRFNGKQTLEDLEACYEGMADAFKGVVMLLVAAGVFAQGLMSIGAIDNLLHLAEVAGAGGIALMLILTGLTVAAAIATGSGNAPFYAFVELAPSLAAKMGLNPAFLIIPMLQASNLGRTISPVSGVVVATAGMGKISPFEVVKRTSVPVLLGLVTVIIGTMVLVPMHA
The following text describes a protein:
Function:
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLIRKSSRRHCYFLINWLLSFTVIILLSINLYVTLYGSPFKASDGSGKFPIDDNINLKVTTQPVQSKSLISPSKRTNNHNQKNPHPSTVHSCNIPYECKDNDLALSITSGPRHDSARICVNGKYYIDAKSSTRGFNVVVINPATKLVVDSLAFDIYAGQSGALVDYINKVTPGHFLAMATADDAFFRISEEVKHAIEQLGSVTIHTLNFRSSWVFVGRKGSKGATLLEEISHGLRYRSGGPKSIATCIPIDIDMKMTNISFFCENHSEFDVLCKKKTVFIPPRIGTGPVKASAKPAYKLPIAIIAGNRPFYLQRCLESLLRVPNIDRSLITIFLDGFVRTPAWIANLYGIRVIVYPKSTTTSKKSLKLRKFDQIAVHYRRSLGTLWDIYPQKSSTIILEEDLVVSPDILDYFSESLPCLKADNSILTISAWNPNGYRSSSFNTSLLYRSDFFSGMGWILTRKLWNEIAPKWPSCCRGVNWDDWLRLSQQRRGRDTIYPDVSRIYHIGAEGVNNENFHKLHYKNQILNTIIGAKLRNVNSVIKAEYDKEIERILKIATPIRYSRSKKKNVCGPSMIPNTSGKNYAIYFYQSSLNDYKFGKELCACFQLWDSGGIRGLYSGIFRFYNKKNHVIAVGSLSKFAKRFMPKRYSSDWLSETATKSKKPS
The following text describes a protein:
Function:
Forms pores that allow passive diffusion of small molecules across the outer membrane.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKLKLVAVAVTSLLAAGVVNAAEVYNKDGNKLDLYGKVHAQHYFSDDNGSDGDKTYARLGFKGETQINDQLTGFGQWEYEFKGNRTESQGADKDKTRLAFAGLKFADYGSFDYGRNYGVAYDIGAWTDVLPEFGGDTWTQTDVFMTGRTTGVATYRNTDFFGLVEGLNFAAQYQGKNDRDGAYESNGDGFGLSATYEYEGFGVGAAYAKSDRTNNQVKAASNLNAAGKNAEVWAAGLKYDANNIYLATTYSETLNMTTFGEDAAGDAFIANKTQNFEAVAQYQFDFGLRPSIAYLKSKGKNLGTYGDQDLVEYIDVGATYYFNKNMSTFVDYKINLLDDSDFTKAAKVSTDNIVAVGLNYQF
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs) (By similarity). As part of the HAT module, involved in negative regulation of sexual differentiation in nutrient-rich conditions.
Subcellular Localization:
Nucleus.
Sequence:
MSSEQQNEADSKPAVIPQCFKIENQYETFSRLSETSTPGVVPSVSTLWRLLFELQKMIECEPSCVEYFRQRKEELESHVDSEIETSKDESSVNKVEEKVEEFKEDNVEQEIKQKRSLSESPQESMLEKVSKKPKVSEAHNEEISPENVETIENELDLPVKGKDEQTTGLVYKNANDLLTGSLLSFIVDDSFSYEQKKKLLCVDSFPTSDVRSLVAGTPATDDFSHNKPNNQISISTFYSSLDPYFRAFNDDDIAFLKKGFDVSSSYNIPPLGERYYDLTPEDEMTNLCANSIYQNLQTSAQGSLEAFNEADTVSEEVRCGPLTERLMASLIPCYTQNDEEQKPSIAVGEFAETDSGSEKSKIGTSIDGIESGNNEYTEQPDIQESSLSICEDRLRYTLKQLGILYDGDVDWSKRQDDEISATLRSLNARLKVVSDENEKMRNALLQMLPEEMAFQEFQNVMDDLDKQIEQAYVKRNRSLKVKKKRIVTDKIGSSATSGSFPVIKSLMDKRSMWLEKLQPLFQDKLTQHLGSPTSIFNDLSDHTTSNYSTSV
The following text describes a protein:
Function:
Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Nucleus.
Sequence:
MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKASAYLSEAMKLTQSEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLKAQQSTDKEAAAPLQASHRPSSEEAEGQSPLLSEKYSPSTEKHLPEIQGVFDRDPDTLLFLLQQKREPAEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGPVDKELDVDADFVEKSELWSLPPHSETAAASSTWQKFASSTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMSN
The following text describes a protein:
Function:
May act either alone or in interaction with glutaredoxin as a redox-regulated transcriptional regulator, or as a factor regulating Fe-S cluster biogenesis.
Subcellular Localization:
Plastid, chloroplast. Mitochondrion.
Sequence:
MAQTLMATTRPYVLLSSTRASLYRLFQSSKRPFASFSAPLVRFTNSRCVSAVLSRKETAPSSIYGNRVSRVSGFGALDIRSLNFSTKSSQINDAGSIDQTLMQSMELKIKEQLNAESVTVTDMSGDGRHVCINVVSSAFEGQSAVNRQRMVYKAIWEELQNVVHAVDQMTTKTPSEV
The following text describes a protein:
Function:
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21 (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MMAAEAGSEEGGPATAGTGGAAATGSSAYPAACRVKLPAAPPMAVAPCPGLADTDLAAALGGGAASGSGFLGTGPVSGVLGGAALTGGAAAGVAGAAAAGPAGDIALTKGTLSLPAETLGPGGGFPPLPPPPLLPPLGSGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQGQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCSLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLAHLLSILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNNTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGVQQHVLKKLLAITELLQQKQNQYTKTNDVR
The following text describes a protein:
Function:
H(+)-stimulated, divalent metal cation uptake system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDSRSPSLPDDRPDPPEQHLDARAGATLRGTAGPRGVRRILPFLGPAVIASIAYMDPGNFATNIEGGARYGYSLLWVILAANLMAMVIQNLSANLGIASGRNLPELIRERWPRPLVWFYWIQAELVAMATDLAEFLGAALAIQLLTGLPMFWGAVVTGVVTFWLLNLQKRGTRPLELAVGAFVLMIGVAYLVQVVLARPDLAAVGAGFVPRLQGPGSAYLAVGIIGATVMPHVIYLHSALTQGRIQTDTTEEKRRLVRLNRVDVIAAMGLAGLINMSMLAVAAATFHGKNVENAGDLTTAYQTLTPLLGPAASVLFAVALLASGLSSSAVGTMAGDVIMQGFMGFHIPLWLRRLITMLPAFIVILLGMDPSSVLILSQVILCFGVPFALVPLLLFTARRDVMGALVTRRSFTVIGWVIAVIIIALNGYLLWELLGG
The following text describes a protein:
Function:
Involved in de novo para-aminobenzoate (PABA) biosynthesis. Acts as a self-sacrificing or 'suicide' enzyme that utilizes its own active site tyrosine residue(s) as the substrate for PABA synthesis. The side chain of the tyrosine residue is released from the protein backbone via cleavage of the C(alpha)-C(beta) bond, leaving a glycine in place of the original tyrosine residue. Reaction requires O(2) and a reduced dimetal cofactor; Was also identified as a specific toxin that associates with death domains of tumor necrosis factor family (TNF) receptors and induces apoptosis in mammalian cell lines through a Caspase-dependent mechanism.
Miscellaneous:
MISCELLANEOUS: Can complement the PABA-auxotrophic E.coli mutant lacking pabA, pabB and pabC genes.
Subcellular Localization:
Secreted. Host cytoplasm. Note=Secreted into the host cytoplasm, where it co-localizes with Fas in the proximity of the inclusion body.
Sequence:
MMEVFMNFLDQLDLIIQNKHMLEHTFYVKWSKGELTKEQLQAYAKDYYLHIKAFPKYLSAIHSRCDDLEARKLLLDNLMDEENGYPNHIDLWKQFVFALGVTPEELEAHEPSEAAKAKVATFMRWCTGDSLAAGVAALYSYESQIPRIAREKIRGLTEYFGFSNPEDYAYFTEHEEADVRHAREEKALIEMLLKDDADKVLEASQEVTQSLYGFLDSFLDPGTCCSCHQSY
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MDEWSSHGQLKCPKQEPCPMADETEYRIEFGPYTEMPTTFARLRNRLKQTDSNAEVLFGHHERPSAKHMITVYDEHINRRARPCNQELPPLRKWNLFRKTWQPERNDFPLTGNPTNWGLANWKDSQHYAGIRDLLEAYKGVQSDYNNSYINHFKKQQNLRRKIPCYLSKD
The following text describes a protein:
Function:
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity.
Subcellular Localization:
Nucleus.
Sequence:
MMTGIAAASFFSNACRFGGCGLHFTTLAELIEHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREQETLKKKIQPKLSLTLSSSVSRGNVSTPPRHGSGSLTPPVTPPITPSSSFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGDEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQGLRHHTINFHPPVSAEIIRKMQQ
The following text describes a protein:
Function:
Protein kinase which is essential for spore formation.
Sequence:
MSNESIYSVLDLTQVIFEDRYLVKQKLGDGSFGTVYLAQRKEKNGLYETVAVKKLKNSSKPKPKHELLKLRESLALRKISKHPCLIDLLETFMDPYRNIFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILVKRISPKPISSRYSIKLGDFGLARPSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVDLYAFGCIVFEIYSLKPLFPGRNETDQLNRVCEILGNPGIDELDTLHYWSQAKELAKRLGFMLPPTKPYPIQKLLPQNCPEGHAKMIPCLLAWNPDVRPTAKYCKEVFFPLPPSASKSNSVPQKISNPKVEQNLGFPISREDKKSTRRVGWLKKNLSEFVSSVKSVFPDSHGSQPHVKTEKPINAKESTGHLANPIASSNVPAISLKPGELHESVFFSENEQIDYLLTSIDYLPSYKPPSNGSNIAINAFNETVGDRIPSSKDILITEKIPFKKENEIRDSIVPSCSQPDESNKEGVASCLLLQKSGMEMTSVLEYSTPNPAEVQNICNDHAKFETSKSLHLSSP