lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MPTFDTTKQIFLCGLPSVGKTSFGQHLSQFLSLPFFDTDHLLSDRFHGDSPKTIYQRYGEEGFCREEFLALTSVPVIPSIVALGGCTPIIEPSYAHILGRNSALLVLLELPIATLCQRLQHRSIPERLAHAPSLEDTLSQRLDKLRSLTSNAFSLRAETSSEAVMRDCQSFCLRFLSTKESSYA
The following text describes a protein:
Function:
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MENNNKNINTTNNSTTINTNNNNNPINKNNNNNNINNNNNNNINNINNINNVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNNINNNNINKKNINNINKNKINNNNNNEIGEEKAVEGGFLAGLSRNVTRIIGSFSSGMAEESAGYPLDLIKTRIQLSQSGVSGGGGTNTSIIKIFKDVIKTEGVIGLFKGLSSPLILSALVTAIQFGLFEDTLKYFRKHQYFKNHDTLSLLFSGSIAGFAQSFITCPVDLVKIQMQIQGIPSSQPNSNNNNNNNKAKGNSYFTKLIYREKGLLGFYQGLSPTLFRDVPGLAIFFTTYETLKKQFGQPELSTQSPTEFIKSFIPIVLSGGSAGVFYHGLTHPFDIAKTLIQSDRSATKYKGTFDCLKQVYQNQGPKSLFKGFSAVAIKSFQSNAVGFLVYEMVINL
The following text describes a protein:
Function:
Involved in a key methylation step in both tocopherol (vitamin E) and plastoquinone synthesis. Catalyzes the conversion of 2-methyl-6-phytyl-1,4-hydroquinol (MPBQ) to 2,3-dimethyl-6-phytyl-1,4-hydroquinol (DMPQ, a substrate for tocopherol cyclase), and 2-methyl-6-solanyl-1,4-benzoquinol (MSBQ) to plastoquinol.
Sequence:
MPEYLLLPAGLISLSLAIAAGLYLLTARGYQSSDSVANAYDQWTEDGILEYYWGDHIHLGHYGDPPVAKDFIQSKIDFVHAMAQWGGLDTLPPGTTVLDVGCGIGGSSRILAKDYGFNVTGITISPQQVKRATELTPPDVTAKFAVDDAMALSFPDGSFDVVWSVEAGPHMPDKAVFAKELLRVVKPGGILVVADWNQRDDRQVPLNFWEKPVMRQLLDQWSHPAFASIEGFAENLEATGLVEGQVTTADWTVPTLPAWLDTIWQGIIRPQGWLQYGIRGFIKSVREVPTILLMRLAFGVGLCRFGMFKAVRKNATQA
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MISSVYFTGVLGNIMSGLVYLSPTPTFWRIVKRRSTEEFESLPYICKLLNAYFWVYYGLIKPDSLLVATVNMFGAVVEIIFLFIFLLYAPPGMKARTAILVAILDVGFPAAAVLLTQFLLHGDVRIDVAGLLCVGFSMIAYASPLSAMKTVVTTKSVEYMPFLLSFILFLNGGVWTFYAFLTKDWFVGTPNGTGFLLGTAQLILYAIYWKPKPSKQQVLNINEDLDQDNDTRQREPLIIPAAGSQSVNAEAET
The following text describes a protein:
Function:
Transcriptional activator that binds to the G-box motif (5'-CACGTG-3') and other cis-acting elements with 5'-ACGT-3' core, such as Hex, C-box and as-1 motifs. Possesses high binding affinity to G-box, much lower affinity to Hex and C-box, and little affinity to as-1 element. G-box and G-box-like motifs are cis-acting elements defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control (Probable). Binds to the G-box motif 5'-CACGTG-3' of LHCB2.4 (At3g27690) promoter. May act as transcriptional activator in light-regulated expression of LHCB2.4. Probably binds DNA as monomer. DNA-binding activity is redox-dependent.
Subcellular Localization:
Nucleus.
Sequence:
MGSSEMEKSGKEKEPKTTPPSTSSSAPATVVSQEPSSAVSAGVAVTQDWSGFQAYSPMPPHGYVASSPQPHPYMWGVQHMMPPYGTPPHPYVTMYPPGGMYAHPSLPPGSYPYSPYAMPSPNGMAEASGNTGSVIEGDGKPSDGKEKLPIKRSKGSLGSLNMIIGKNNEAGKNSGASANGACSKSAESGSDGSSDGSDANSQNDSGSRHNGKDGETASESGGSAHGPPRNGSNLPVNQTVAIMPVSATGVPGPPTNLNIGMDYWSGHGNVSGAVPGVVVDGSQSQPWLQVSDEREIKRQRRKQSNRESARRSRLRKQAECDELAQRAEVLNGENSSLRAEINKLKSQYEELLAENSSLKNKFSSAPSLEGGDLDKNEQEPQRSTRQDVA
The following text describes a protein:
Function:
May be required for vacuolar fusion. Overexpression leads to fragmentation of vacuoles, missorting of the vacuolar enzyme carboxypeptidase Y (CPY) to the exterior of the cell and accumulation of multivesicular bodies inside the cell.
Miscellaneous:
MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein. Note=Binds to various phospholipids.
Sequence:
MPDNNTEQLQGSPSSDQRLRVDWDNGNHFDVSPDRYAPHLSEFYPIVNSKRPVASSAGSENNDHLDDMNHLRSSKVYSKARRASSITSGTSTINDLQTLITKRDVKETQEALSTLLRNSNAYSDSLLKTSQNGAEIAHSLENIAKLKGCNDETAEKLLSASGLFYLLSNHQLIMSKYFNDLLGDNLIDDIDEFELQTKIMENKFKAQSKEQSLKLKLQERHNFDISKRKIRNLISYRESLSSLQARLDQLETLKHDFYMDSYELVENTCNKVLSKVATVSRAQVEISENIARKGWSGGGLDELLCDADDPFSKKADGPYGTIGGDGETAGEAYNSDEETGGNDVVLNELLEGTSQPSTSKTSLPKSKGSSTVSTPNHSQSSSNKDGVRNNGGGKNGEDEDTDNLMGTENSFSLPPTRNSAEETTQTFKQLSIKEDNDNHSSDTDGMQDQSSNI
The following text describes a protein:
Function:
Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein. Note=One of the very few enzymes located there.
Sequence:
MARFWQILIALLLVPTLAQAEEATIEKIHDAPAVRGSIIAAMLQDHDNPFLLYPYETNYLLYTYTNEINKQAISSYDWAEQANKDEVKFQLSLAFPIWRGIAGDNSLLGASYTQRSWWQASNSEESSPFRETNYEPQLFLAWSTDYELAGWTFREVEFGFNHQSNGKADPTSRSWNRVYTRVMAQRGNLEIDLKPWYRIPESDSKDDNPDITKYMGYYRLKVGYALGDSVFSLDGRYNWNTGYGGAEMGWSYPITKHVRFYTQVFSGYGESMIDYNFRQTRVGVGIMLNDVL
The following text describes a protein:
Function:
EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression. Required for the formation of P-bodies. Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism.
Subcellular Localization:
Cytoplasm, P-body. Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Mainly localizes to processing bodies (P-bodies). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.
Domain:
Intrinsically disordered protein with multiple low-complexity regions that confer binding to multiple RNA translation, deadenylation and decapping factors; The YXXXXLphi motif mediates interaction with eIF4E (EIF4E and EIF4E2).
Sequence:
MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDVLQQPLPSMPAKVISVDELEYRQ
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MSAVPLRNNKAAASAVRSVTVLGATGSIGDSTMDLLRASPERYRVEALTANGNVEALAKLAKEFSARFVAIADTSKFAELKAALAGTSTECGAGESAVIEAGARPADWVMAAVSGAAGLKPALAAVDRGAHVALANKECLVCAGDFFMQRAAKAGACILPADSEHNALFQALGSGNRDELVRVIITASGGPFRTWKPADIEQATLAQALKHPNWSMGQKITIDSASMMNKGLEVIEASYLFALSPDEIDVLVHPQSIIHGMVEFSDRSVVAQLGSPDMRTPIAHCLGWPDRIKGPAAKLDLAKIGQLTFEAPDFERFPGLRLAYDSLRTGKGATTVYNAANEVAVAAFIAGKIRFGAIARLVEATLEDWIRGGNQTPLTSADDAISVDHVARNRAAALLPQIALKAS
The following text describes a protein:
Function:
Component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope. Involved in the formation of the bipolar mitotic spindle. Anchors the spindle pole body in the nuclear envelope.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Central core structure of the nuclear pore complex.
Sequence:
MVMLRTSFPSGSRTKAVRYHTLLRPILQQRFLRACFALLCLCCITSYWFSSGPFISLSFWFLSLVRGFVCFFFMFPYFVMLKSRMSTQKVTKQSLGAQLFYDFSPKSFFLVYLTFAVSVSCLCLFYIKGHASSIRLQWIASPNAYELPSLNERFVYMTYFSHILILALTVEHLYLQRDSPSRPVINVSFFNYIFQNLGWLIRFSFRKSIICCLFTPFSYAILRSYIWRFAALLTSCCRRIAYTKTPPKWPLSLRLLLHSFWMAFIVCLTFQIALLIFRVFLYSGPMIRGKLLSARSNDPNGTLVDGMKTKKKPLTECIATEELWFIAKRDPQRIKSIFQDIDRSVSIWQELYSITESRCKELATSLKILQSTGDFSAATSKKSGLTKKTNIPYSPNSNHEEINSIPLRNKNIFVPPSQGHSPLLEKIKKQGSLPSTTPVNEGGISDIIPKSLYDQVIRFISTFYKAPVFGIFRKTLRRQNEALLPNPWLFCVTVNSLTQLVLKSLKYDTYGVVARDISSILAVYCDTFDVLVSYKRSLVKNHSNSTNLDDDFKNLNSAANALHCGIIDITEKFQDFFTQLNLSPRIERRCWVLFREYKSNS
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPYLNPQRIRAALRALNLRPTRGMGQNFLLDGQVLATIVDEAKLNASDAVVEVGPGLGVLTWELVQRAGRVICVELDRRLADRLAAEFRDQSHLYLIQGDVLKVAPSDLLARAAATPPYKLVANIPYAITAPLLRHFLEATTPPDLSILLVQWEVAERICAGPGDYSVLAHAVQLYAEPTIVARVPAASFFPAPAVDSAILRLVRRPQLAVAVDDVNALFRLIKAGFLHARKQLGNALPGGLAALGVTVSREHVVQALHAAGIDPQRRAETVTLAEWAKLLAVLSESGV
The following text describes a protein:
Function:
Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity).
Sequence:
MYTNLPKACLTGIVLTISTHSGPQVVYHYPPVKQPVEARRGRKVDSRNERVRSWQAGRMPSAASGAVDAVGEGVDGLEEESSESELDRSSGLSESEVSTDWADYSMSSSDSESEMREDGGGESSAVGGSSAAEGGEESLAEGADSSIAWPGPSESYNQLLESQSMVGSSANVAAASTKPKSIKSRHSQISANKLFQYLTNTSDADSRRQSVFSKLTGNEDSETIRLTDSVNLLDLESLLEDLEPGLADVDISELLDVEVFQPGRFQDVSKIFNFDAEFVAELCSPPKEMCNTRFELTVDDLCFLGLPIHVDESGRWRKQKVKRQQTNTRSKRSSSGGKPDAGSRTSVGLPHGTQERQPSTDQSGSGAPYLAQSSSESGQLRDPEQSDDVEDLQKAVHMFHVCFIMNPQLVEYNERIDDMYHYIVTRLSLILRYIQDKKGYVVRECAKILKTRDRILKKSLKLKKSHGQALQGRYLYECILKSSSLARALTKCFNSIINNEIVTLDIDNHKVISLQIPIKNEFSSLPDLKINPVLRGSYLTSLLNDSFLKQPVDFAAGSMMPGGDVMHDDNDVLDYALLLLDDTPKIIKDLEFSSFGSDLANVIMINLVKNLKPTVSLRSYLPLVSNLLEANLSLSARAAGSRHAASNAADSHSTPLQHSMIRSIVLHLVYWRYARIILPLSSKNTYIVSPLAPIRGTAADDFENTDMVKQGCKALIYQHQDLFHEKFPTLPTLPSFLSSISTCKPRSFGHLIPSKDHNLLYLSVLAWLIRYGYLTQLLTFVWLRVDRRIKIAVDEDLEREGVRTWNSIVKKEHRQNPHDNVAAPTREPASSAIDETASSSEHGDANISDGQESLDDYLFKESDYTIILEPKTATALEKRWLFKCIENQPTEMQLLFRKVIKYFNGKTPLELVEIKENIPKQELKKLIACLDKYVVELKHW
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
Sequence:
MRFIKWLDEIGKKDILLAGGKGANLGEVAKMVQVPPGFVITTEAYLHFLNVTGLKDRINEVLKEFISKGEPDEYEKASTVIRGLIESSPLPSDLEKELLEAYKKLGEIVGMANVPVAVRSSATAEDIPEASFAGQQDTYLNVKGAENVIYYAKKVWSSLYTPRALYYRDKMGIPHEKSLMAVVVQKLVNARSAGVIFTLDPTTGDRSKVVIEASWGLGEGVVKGIVTPDEFVVDKSSLKIVERRISPKKVAVVRDEAGLVKEVQLPPEKVNAPALSDEEVVELAKMAIKLEEYYGHPVDIEFAVDADMEYPRNLFILQVRPETVWSRKAERPAKAAEEAPVGTVVVKGIPASPGIAVGQAKICLTLEDAKRKLKKGDILVTKMTDPDWVPYMRLASAIVTDEGGRTSHAAIVSRELGIPAVVGAGNATSVLKDGETYTVDGSKGIVMVGAVVKKEEAKAVEVGVAAPPKEIILHIYRAVPTATKVYMNLGEPDKIDEYKDLPFDGIGLMRIEFVISSWVGQHPLYLLSIGQEHKFVNKMAEGIAKVASAIYPRPVVVRFSDFKTNEYRGLEGGEKFEPEERNPMLGWRGVSRYISPQYERAFRLELKAIKKARQEMGLNNIWVMAPFVRTVWESEKFAKLLEEEGLYRDRDFKVWAMAQVPSIAFMVQEFSEYFDGFSIGSNDLTQLVLGVDRDNDFLVRINPKYFDEREAPVLRAIYELIKRAHKMGRTVSICGQGPSVYPQLVEFLVRGGIDSISVNPDAVLQTRVLVASVELKVLRERLDAIYNALYKPDESSEFYDILKKVFGQVRY
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Subcellular Localization:
Mitochondrion membrane.
Sequence:
MAAPKLGFFEKIANLTGALYRHQHAQFPRRFAILKAVGKHELAPPRQADWPAIKADWAKVQSFIQTGGYKNLSIREGLVYTAVTLEVVFWFFVGEMIGRRYIFGYLVPADYVSKSTKKTVKEQEALAALEN
The following text describes a protein:
Function:
A humoral factor that may play a role in stress tolerance.
Subcellular Localization:
Secreted.
Sequence:
MKVPVFQLSCLLCLIVCLLCSVKAQKDDQYDTEKSRILEIYNNPAVDEFTKERNIPKLIEFYRRYPARIQLPDADKRQWDEFVARYTESQTKLVDGLPAQGGWVGSVLSSTVGNLIAKFIFSLIRYDPTTPKPTGAH
The following text describes a protein:
Function:
Endonuclease that is involved in the suppression of homologous recombination and may thus have a key role in the control of bacterial genetic diversity (Probable). Also involved in repairing oxidative DNA damage. Has ATPase activity. Binds DNA; Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity; Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC.
Sequence:
MSDAPKRSLNPTLMMNNNNTPPKPLEESLDLKEFIALFKTFFAKERDTIALENDLKQTFTYLNEVDAIGLPTPKSVKESDLIIIKLTKLGTLHLDEIFEIVKRLHYIVVLQNAFKTFTHLKFHERLNAIVLPPFFNDLIALFDDEGKIKQGANATLDALNESLNRLKKESVKIIHHYARSKELAPYLVDTQSHLKHGYECLLLKSGFSGAIKGVVLERSANGYFYLLPESAQKIAQKIAQIGNEIDCCIVEMCQTLSHSLQKHLLFLKFLFKEFDFLDSLQARLNFAKAYNLEFVMPSFTQKKMILENFSHPILKEPKPLNLKFEKSMLAVTGVNAGGKTMLLKSLLSAAFLSKHLIPMKINAHHSIIPYFKEIHAIINDPQNSANNISTFAGRMKQFSALLSKENMLLGVDEIELGTDADEASSLYKTLLEKLLKQNNQIIITTHHKRLSVLMAENKEVELLAALYDEEKERPTYTFLKGVIGKSYAFETALRYGVPHFLIEKAKTFYGEDKEKLNVLIENSSALERELKQKNEHLENALKEQEYLKNAWLLEMEKQKEIFHNKKLELEKSYQQALNILKSEVASKDTSSMHKEIHKASEILSKHKTNQEIPQIITNFQANEKARYKNESVLIVQILDKGYYWIETELGMRLKAHGSLLKKIQKPPKNKFKPPKTTIPKPKEASLRLDLRGQRSEEALDLLDAFLNDALLGGFEEVLICHGKGSGILEKFVKEFLKNHPKVVSFSDAPINLGGSGVKIVKL
The following text describes a protein:
Function:
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
Sequence:
MNPNFTTEHTWQGRHDPEDGQAGRRVHHIACPIQVGELANQEPGVALIGFECDAGVERNKGRTGAKHAPSLIKQALANLAWHHPIPIYDLGNIRCEGDELEQAQQECAQVIQQALPHARAIVLGGGHEIAWATFQGLAQHFLATGVKQPRIGIINFDAHFDLRTFESELAPVRPSSGTPFNQIHHFCQQQGWDFHYACLGVSRASNTPALFERADKLGVWYVEDKAFSPLSLKDHLTQLQHFIDDCDYLYLTIDLDVFPAASAPGVSAPAARGVSLEALAPYFDRILHYKNKLMIADIAEYNPSFDIDQHTARLAARLCWDIANAMAEQVQSIRHP
The following text describes a protein:
Function:
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme.
Subcellular Localization:
Secreted. Cytoplasm. Cytoplasmic granule. Note=Detected in secretory granules of parotid acinar cells and gastric chief cells and secreted from them into saliva and gastric juice, respectively.
Sequence:
MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MYILKIAYDGRYSFQQQPHKQTVCDILLDALEETGFLAKKKVIYSGGRTDKGVSALGNFVVVELKKEPILSYINAKLKDKGIWVLGYREIDEIPKVKYRHYRYILPNIGYDVDAIKEGAKKMIGTHSFHNLSKRDRTKEKSPIRTIYDIKISENEFYLTVDIIGESFLWNMVRKIVGALDLVGRGKKPVEWIDKLLDENHREGVPTFPPEGLILVEAKVDIEYIYDNYSIRKFKEYWGEFFKLQVMKIGIAKTVLEFTK
The following text describes a protein:
Function:
Transcription factor that controls hypaxial muscle development by down-regulating myod1 and cdkn1b/p27, thereby allowing myoblasts to proliferate before the onset of terminal differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MKRQKRLMDPPNKSLTPFSIADILNKCPPQQLPPTPQSSPLSALLELTSKTFQGLDFSLLTPGRETPSSFGHCNGSKKRRKSRTAFTNRQIYELEKRFLYQKYLSPVDRDHIAQQLGLSNAQVITWFQNRRAKLKRDLDEMKADVESLKKLPPHSQEKLVSVPVLGVTGGDGVTGRGCCPKSRDTVSQPPQCCLLDPTGDEFSDEEEIDVDD
The following text describes a protein:
Function:
May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRHAGSWKLWPWVAVLLLPASTSVTVRDKSEKQCPVLRTEGHQFSQDNRAKLEVSGFDLGESFSLRRAFCEGDKTCFKLGSAFLIRDTIKIFPKGLPDEYAIETIFRVRRSTKKERWFLWQVLNQQNIPQVSIVVDGGKKVVEFMFQAAEGDVLNYIFKNRELRPLFDRQWHKLGIGIQSWGISLYMDCNLIASRHIDEKDTVDLRGRTVIAARASDGKPVDIELHQLKIYCNSNFIAQETCCEISDTKCPEQDGYGSTASSLLPAHASKMSAYLPVKQELQDRCQCIPNKGEAGLPGTPVSPGQKGDKGEPGENGLHGAPGLPGQKGEQGFEGSKGEIGEKGEQGEKGDPGPAGINGQNGLKGDLGPHGPPGPKGEKGDTGPPGPPALTGSLGIQGPQGPPGKEGQRGRRGKTGPPGKPGPPGPPGPPGIQGVQQTLGYYNKGETGQPGFPGSIGPKGQKGESGESLSKGEKGDRGEPGLIGSQGIKGEPGDPGPPGLIGSPGLKGQEGPAGSMGPRGPPGDTGLPGEHGIPGKQGIKGEKGDPGGIIGPPGLPGPKGEAGPPGKSLPGEPGLDGNPGTPGPRGPKGERGLPGVHGSPGDRGPPGVGVPGRTGSQGPAGEPGIQGPRGLPGLPGTPGTPGNDGAPGRDGRPGLPGPPGDPIALPLLGDIGVLLKNFCGNCQASVPGLKSNKGEETSAGEPGKYDSIAQKGDTGPRGPPGIPGREGPKGSKGERGYPGIPGEKGEEGLQGIPGLPGAPGPTGPPGLLGRTGHPGPSGTKGDKGSEGPPGRPGPPGPPGVPFNEGNGMSSLYKIQGGVNVPSFPGPPGPPGPKGDPGPVGEPGAMGLPGLEGFPGIKGDRGPAGPPGIAGISGKPGAPGPPGVPGEPGDRGPVGDIGFPGPEGPSGKPGINGKDGLPGAQGIMGKPGDRGPKGERGDQGIPGDRGPQGEQGKPGLPGMKGAIGPVGPPGNKGSTGSPGHQGPPGNPGIPGTPADAVSFEEIKQYINQEVLRIFEERMAVFLSQLKLPAAMLAAQAHGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLPGSPGLPGTSAPGLPGSPGAPGPQGPPGPSGRCNPEDCLYPVSHARQRTGGK
The following text describes a protein:
Function:
Sterol 14alpha-demethylase, encoded by cyp51A, cyp51B and cyp51C, that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (By similarity). Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4'-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity); As a target of azole drugs, plays a crucial role in azole susceptibility.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MGILAVILDSVCERCSGSSLWMLSTVALLSILVVSVVINVLRQLLFKNYKEPPLVFHWFPFIGSTISYGMDPYRFFFNCREKYGDIFTFVLLGKKTTVYLGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKGPNGVFDVCKTIAEITIYTASRSLQGKEVRSRFDSTFAELYHDLDMGFAPINFMLPWAPLPHNRKRDAAQKRMTETYMEIIKERRKAGSKKDSEDMVWNLMSCMYKDGTPVPDEEIAHMMIALLMAGQHSSSSTAAWIVLHLAASPEITEELYQEQLRILGHDMPPLTYENLQKLDLHAKVIKETLRIHAPIHSIIRAVKNPMPVEGTPYVIPTSHNVLSSPGVTARSEEHFPDPLEWKPHRWDEAIAVSSEDEEKVDYGYGLVTKGTNSPYLPFGAGRHRCIGEQFAYVQLGAITAALVRLFKFSNLPGVQTLPDTDYSSLFSKPLGNSKIQFEKREPVTKA
The following text describes a protein:
Function:
NADH-dependent flavin oxidoreductase. Stereo-specific NAD(H)-dependent 3-oxo-delta4-cholenoic acid oxidoreductase involved in bile acid 7beta-dehydroxylation.
Sequence:
MDMKHSRLFSPLQIGSLTLSNRVGMAPMSMDYEAADGTVPKRLADVFVRRAEGGTGYVMIDAVTIDSKYPYMGNTTALDRDELVPQFKEFADRVKEAGSTLVPQIIHPGPESVCGYRHIAPLGPSANTNANCHVSRSISIDEIHDIIKQFGQAARRAEEAGCGAISLHCAHAYMLPGSFLSPLRNKRMDEYGGSLDNRARFVIEMIEEARRNVSPDFPIFLRISGDERMVGGNSLEDMLYLAPKFEAAGVSMLEVSGGTQYEGLEHIIPCQNKSRGVNVYEASEIKKVVGIPVYAVGKINDIRYAAEIVERGLVDGVAMGRPLLADPDLCKKAVEGQFDEITPCASCGGSCISRSEAAPECHCHINPRLGREYEFPDVPAEKSKKVLVIGAGPGGMMAAVTAAERGHDVTVWEADDKIGGQLNLAVVAPGKQEMTQWMVHLNYRAKKAGVKFEFNKEATAEDVKALAPEAVIVATGAKPLVPPIKGTQDYPVLTAHDFLRGKFVIPKGRVCVLGGGAVACETAETALENARPNSYTRGYDASIGDIDVTLVEMLPQLLTGVCAPNREPLIRKLKSKGVHINVNTKIMEVTDHEVKVQRQDGTQEWLEGFDYVLFGLGSRNYDPLSETLKEFVPEVHVIGDAVRARQASYAMWEGFEKAYSL
The following text describes a protein:
Function:
Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.
Subcellular Localization:
Synapse. Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor.
Sequence:
MAISCRQSRVLPMSLPLPLTIPLPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSASISPRLQLLGIAALIYICAALRTKRVF
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSLPTPFATPYNSNFSDDAETGHAGTAPAAAFDSEEVPLSPRALPHRASNATRPELTLAGGDAKRPFRDVLWAGLFLGHLGLIGWALVVWGKMRFDGPDRHSQTTTYWPQYGGAAGLGIVLTWAWLWLFRRCSADMIKMSVHSVSTFGAVLSVLLFWNHSPLWGIGFAAGAAVAFVFSFTVTDRLPFTALVIQKAVDLVGDFPSTLYVAFLVGVVSLAWLALWTFGAAGTIALSSEKHRWAKLFLLSVSLLWTAVVAHNVVHVAAACAFAQWFLAGGEGQPPEHRSSRGLVVALTSSFGSVCFGSLLSPPVRTLRWLARGLRGRMRSNECMLCCLDCYLGLLEGFVRIFNKYAYVHMAIGGKGFNRASTDAWERFQLTGVEALVAQDLSGAVLLLSVALGGLITGTVVGTWVHYTQEDRTVPVAVTGALLSMMLIGLVTAVIEAGVTTIYVMFAEDPALISRWDPEFGSELEAMLNERLARRARKPLIDNPRNQP