lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids. Capable of oxidizing short as well as long chain 2-methyl branched fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MGSPMHRVSLGDHWSWQVHPDIDSERHSPSFSVERLTNILDGGLPNTVLRRKVESIIQSDPVFNLKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPERIYANRVLDGNVNLSLHGVAMNAIRSLGSDEQIAKWGQLCKNFQIITTYAQTELGHGTYLQGLETEATYDEARQELVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYAFHFTATSLSEFFHSSYSAILKRDFSLLPELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVARFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWAYVSTRLIRDAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAHCYFITVKNFKEAVEKLDKEPEIQRVLQRLCDLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYERLFEWAQKYPANTQENPAYKKYIRPLMLGWRHKM
The following text describes a protein:
Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Nucleus, nucleoplasm. Note=After ligand activation, translocates from the cytoplasm to the nucleus (By similarity). The hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20. Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20. Upon dexamethasone binding associates with the glucocorticoid response elements of target genes (By similarity).
Domain:
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.
Sequence:
MDPKESLTPPSREEIPSSVLGRERAHVMDFYKSLRGGTPVKVSAASPSLAAVSQPDSKQQRLAVDFPKGSGSNAQQPDLSKAVSLSMGLYMGETETKVMGSDLGFPQQGQISLSSGETDFRLLEESIANLSRSTSVPENPKSSASAAGPAAPAEKAFPKTHSDGAPEQPNVKGQTGTNGGNVKLFTTDQSTFDIWRKKLQDLELPSGSPGKETSESPWSSDLLIDENCLLSPLAGEEDPFLLEGSSTEDCKPLVLPDTKPKVKDNGELILPSPNSVPLPQVKTEKEDFIELCTPGVIKQEKLGPAYCQASFSGANIIGGKMSAISVHGVSTSGGQLYHYDMNTAASLSKQQEQKPLFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFSGRSVFSNGYSSPGMRPDVSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENSANKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSIPDSTWRIMTALNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMVFALGWRSYRQSSASLLCFAPDLVINEQRMALPCMYDQCRHMLYVSSELQRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHDVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQLPKYSSGNIKKLLFHQK
The following text describes a protein:
Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MIHLVDYALLKPYLTVDEAVAGARKAEELGVAAYCVNPIYAPVVRPLLRKVKLCVVADFPFGALPTASRIALVSRLAEVADEIDVVAPIGLVKSRRWAEVRRDLISVVGAAGGRVVKVITEEPYLRDEERYTLYDIIAEAGAHFIKSSTGFAEEAYAARQGNPVHSTPERAAAIARYIKEKGYRLGVKMAGGIRTREQAKAIVDAIGWGEDPARVRLGTSTPEALL
The following text describes a protein:
Function:
Is required for the biosynthesis of pyrrolysine. Catalyzes the ATP-dependent ligation between (3R)-3-methyl-D-ornithine and L-lysine, leading to (3R)-3-methyl-D-ornithyl-N6-L-lysine.
Sequence:
MKTICLIGGKLQGFEAAYLSKKADMKVVVIDKNPQALIRNYADEFHCFDVIKEPEKLLEISKNVDAILPVNENLECIKFLSSVKEEFSCPVLFDFEAYRISRDKKKSKEYFRSIGIPTPQDKPGRPPYFVKPPCESSSVGARIIYDEEELGELEPGMLVEEYVEGEVISLEVIGDGTHFAVVKETLIHIDRTYDCHMVTPLPSDLSFREISYSLAANLPLKGIMDVEAISGPQGLKVIEIDSRFPSQTPTAVYYSSGVNLIELLFRAFGEGVEEVKTLPEDRYCIYEHLMLAENGALIPVGEQVLSMGNDYGKYYEEPGIEIFLCRGEDPVFTLVFWGKDREEAENKKRTGLLILKDRFGAAV
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. A translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome; YafO alone is not able to digest mRNA.
Sequence:
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRTNDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAGLPSTIYNTVFKRTSTFALACVCATFFFERTFDLGSEYLFEKVNEGKLWKHIKHNYEK
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MNSSTETMDVFEFKVEDSDIEANRFCTKYTSTENGALGANINLKVTGDEPSEDIEAADGDFNGSHALSSLDAGGCSDERKLRLSSMPKINSTNKRRYPDREPNNRIGGSLLEGSSYSGTAFQELFSGSPSNDESVGAVSDIDESISEESASYSSATPENLDILDGALSSRHLDHWGMFENKPIIFCPDYLYYQGISYAVIDTTVTFSSDCVEVKGSTMNENSGAFCIRFEVEDIFRIQPRLSRRFDVAVFKIHVNKRSTTQGENAHETSGIEEVEFAVNDFDLSEKCEAIQSLDVYKAVWNYRNENEELRENSHGETSDQLPKRYFPSYGEPLEEVIYPKGDPDAICISKRDFDLLAPDTFVNDTIIDFYIMYLKNRISPENRRRYHFFNCFFFRKLADMDKDPNSAFDGHAAFLRVRKWTRKVDLFDKDFVFIPVNYNYHWSLIVICHPGEVAKYDDIAANSLRVPCILHMDSFRGSHVGLKGLLQSYLWEEWRERTKETSDVVSSKFQNLRFLTLELPQQQNLSDCGLFLLHYVESFLEEDPAGISPYSIKNYHNEFLSINWFQPHEPSIKRSAIQRLISNLLQNRSLENSPSCASNSCYPEGGLKTSKDDENAVELVSNQLGSSKNSDNLPCSQAIEINPFPASSLGGVCASDSGFVLNESFESESDEQPLLDMRFGHSASFNEFRSSLPPIQEEVEAGDLVYTATETGLQHLDGNGSEPCAFSYSSGSLAVGTSWIPGVSVVQDVHDELDSPPTTSVPDTENPLEAEVVEPCQVDHNMSSDEKIDHPRSSIDCLVDGHATSGELLDITLAQCSVETHGNSGTGPVAFGEENPYDIHGNVNLACKSLLLIGSGSGSEVDPQHNVKRRRLTPLDEEEAAFRSNLSRDLHL
The following text describes a protein:
Function:
Plus-end directed kinesin-like motor enzyme that plays a critical role in the organization of phragmoplast microtubules during cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, phragmoplast. Note=Localized to the midline of the nascent phragmoplast (late anaphase) essentially at the plus end of phragmoplast microtubules.
Sequence:
MSTTLRRAWSSLNGNDGVLPYFLATLNEVSLLQARPPPGHAAAALALRRRRRDTPPSRRRVPKENVDPGSSPAGHSPFRSPTSSAKPLGNRNRGLLPPRPPSSNPLKRKLDVSPAAAADSSGGAAAAAAAAGGGCPAPDSGVQVVVRIRPPCRVEEEEDARAPDLCVRKTATNSVAIQGQDFTFDAVADEVSTQEDIFKLVGLPLVENCLSGFNSSIFAYGQTGSGKTYTMWGPLSALSEDSTCSERGLTPRVFEQLFSRIKEEQGKHEDKELTYHCVCSFLEIYNEQITDLLDPSPKSLQIREDVRTACVYVESLTKELVFTTKDVTQLLVKGLSNRRTGATSANADSSRSHCVFTCVIKSESKNLEDGSNSTRTSRINLVDLAGSERQKLTHAFGDRLKEAGNINRSLSQLGNLINILAEISQSGKQRHVPYRDSKLTFLLQESLGGNAKLAMICAVSPSQSCKSETLSTLRFAQRAKSIKNNAVVNEQKEEDVNMLREQIRQLKDELHRMKSGGSDGSNGSFSTGWNARRSLHLLKMSLSRPTTFQTIHEDSGDVEMEIDENDVEKPYNQDNMVISPPGDKECKELQASLKINGGTSLDVFDGENLMPTKRSCSDDRYKLNLAASIQRGLQVIENHQNNGAWRRASVGFNARIVDVQPCKVDVAIQTEPEESEARDNPLALISSHVLGTSATVSNDPNACRDLQLVQYDAGITRDEPKQQQILKAVEKVLAGAIRREMARDEQCVKQAAEIQQLNRLVQQYKHERECNAVIAQTREGKIARLESLMDGTLPTEEFINEEYLSLMNEHKILQQKYENHPELLRAEIELKRLQEELELCRNYIDEKEVLQEEIQDLKSHLHFMLSSSASIRRLWPPVQLSHGVGPSPVTNDADGDNNAVDTPDWAEAESKWVTLTEELRVELEANKSLVGRLRSELESEKKCSEEVKEALQTAMQGHARILEQYAELEERHIGLLAMHRKIREGVEDVKARAAKAGVKGAELRFINSLAAEMAVLRAENKGLQDQLGDTAEAVQAAGELLVRLKEAEEAEALAQRRALLAEQETEKAYQEIDNLKKNYDQEIVALNQRLSESSHHQETTLAIEACDMETTKYDTAGSPGDQQWREEFNQQGGSFEVSKSTDLNSWFSGYDKCNI
The following text describes a protein:
Function:
Binds to the DNA sequence mediating pheromone induction (called the pheromone response element = PRE) which is found in the upstream control region of several a-, alpha- and haploid-specific genes. Involved in mating of haploids and in pseudohyphae formation in diploids.
Miscellaneous:
MISCELLANEOUS: Present with 1920 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The DNA-binding domain seems to be involved in the suppression of pseudohyphae formation under nitrogen-rich conditions and in haploids. This region is also involved in the regulation of budding pattern of haploids.
Sequence:
MKVQITNSRTEEILKVQANNENDEVSKATPGEVEESLRLIGDLKFFLATAPVNWQENQIIRRYYLNSGQGFVSCVFWNNLYYITGTDIVKCCLYRMQKFGREVVQKKKFEEGIFSDLRNLKCGIDATLEQPKSEFLSFLFRNMCLKTQKKQKVFFWFSVAHDKLFADALERDLKRESLNQPSTTKPVNEPALSFSYDSSSDKPLYDQLLQHLDSRRPSSTTKSDNSPPKLESENFKDNELVTVTNQPLLGVGLMDDDAPESPSQINDFIPQKLIIEPNTLELNGLTEETPHDLPKNTAKGRDEEDFPLDYFPVSVEYPTEENAFDPFPPQAFTPAAPSMPISYDNVNERDSMPVNSLLNRYPYQLSVAPTFPVPPSSSRQHFMTNRDFYSSNNNKEKLVSPSDPTSYMKYDEPVMDFDESRPNENCTNAKSHNSGQQTKQHQLYSNNFQQSYPNGMVPGYYPKMPYNPMGGDPLLDQAFYGADDFFFPPEGCDNNMLYPQTATSWNVLPPQAMQPAPTYVGRPYTPNYRSTPGSAMFPYMQSSNSMQWNTAVSPYSSRAPSTTAKNYPPSTFYSQNINQYPRRRTVGMKSSQGNVPTGNKQSVGKSAKISKPLHIKTSAYQKQYKINLETKARPSAGDEDSAHPDKNKEISMPTPDSNTLVVQSEEGGAHSLEVDTNRRSDKNLPDAT
The following text describes a protein:
Function:
Part of the dynein complex of respiratory cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSVSYKVGTVKSKQSPNVNTQPKAPVVKGVKTTGKKKDEEEGIDTADGEEWMQGKTLVKPPDQLDLTEEELKEEITRVLTANNPNAPQNVVRYSFKEGCYKTIVFVDQMAIHFELEGNLVHKESDEGRRLMAKHTEREDCGGDERLENVPIKPGKREQKVTNQFNFIDRASQTLNNLPREISCQTEPPPRANFSATANQWEIYDFYVEELQRREKSKEKQESQFPNKEEDRSKKKMIQAEAQSDDISQLAKPAKIIERMVNQNIFDEVAQDFMYFEDAADEFRGEKGTLLPLWKFQYDKAKGLSVTALCWNHIYSDLFAVGLGSYEFTQQERGMLLFYTLKNPSFPEFIFNTDSGVMCVDIHEQLSYLVAVGLYDGCVSVYDLRKKSDQPMYNSIASSGKHTGAVWQVKWQKDDLDSNHNFFSVSTDGRVVSWTLVKHEIVFTDIIKLPPVDKVPDDLKNVVATAGTSLDFHKQKDHHFLVGTEAGKIHKGSKYYSSKFLEMYDAHFMTVSCVRWNPFHPNVFISCGWDWMVKIWDHTINSPVFTFELKSSVTDVAWSPYSSTVFAAVTADGKVHVFDLSINKYEALCQQKVVSKKTRLLHIEFNPVHPIIIVGDDRGRVISLKLSPNLRKKPKEKKGQELPKGPEVEIAKMEQLLSSLR
The following text describes a protein:
Function:
Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular Localization:
Nucleus.
Domain:
The SBP-type zinc finger is required for the binding to DNA.
Sequence:
MDSWSYGRSVFMSNETLLPCDTFAKNRRFEQRLSNNDDVLISDMAGNSNGFSAVSITKVVPEEEDEENISSSSKFSSQELNRIDFKLRSFLDLGNDDDDTSSRGFALPSKKSRASNLCSQNPLCQVYGCSKDLSSSKDYHKRHRVCEAHSKTSVVIVNGLEQRFCQQCSRFHFLSEFDDGKRSCRRRLAGHNERRRKPAFYFLPGKRHKLLRTSQDVVGNKFLENSSLVLPESFPGSLLYRVIDEDDHRTSRLVSFKDEPTCSMFPTNEQNSSRTYESKPAIYSTEVSSIWDLHETAASRSTRALSLLSAQSQQHLSKFPNTTFSITQPNQNLNHSSSTDYHQMEQPLWIDPGKTNSAGSSSCKGKGTSTVDLLQLSSHLQRIEQQRNYTGDVKQEYNELYFPGS
The following text describes a protein:
Function:
Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MLPTVPLYLLPGVLPMTQVNPFYNFSGMDPMMTPPFLPVPSIFNMQTNLINVMSMQAMTPLPQPNALSLTGLPTIIPTVPLPEAIRKKSSYQIYTIPSAGQQTLGNEKNRTAKNIKKPLNAFMLFNKENRNTSLEENEYDQMPILTPMVPTLEAMKTESANQIDTIPSTVQRVSLNRRQKKENYIKKPLNAFMLFIKENRKTVLEENGYDQIPAGEINKELGRRWRETSHEERQKYFELARIEKQLHKDKYPEWSAKDNYPKNPKKANKRIHDPTQHLAEMCRARFGIENKAKWCKYCLQKKKCILSREITQSYEEEITSETSRGSTETASSSATTPTDLALNQASSTPQSREESLQTSLSTNSEAEEEEKA
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MRLFTFKLESKLIARRRHHVTPSLRGSLVPLRRRHESSHFRFSDNDKSLPSSHRPKVRWKASSLPRRRSSQSRSRNRRKGHFVAGLHRSPFRENEEKVIALHPSTENIASFFGTCLNRLNAISSVGILSVPYALASEIRLSLAFLFAIATVVFYTYMLIKKCMDKYLNSRTYPDIGELAFGKIGRLIVSVPMYTKLYLVSIGFLILEANNLIWLDNLSLLSYVSASGVFAFTFIILSISWTATFDGVGFHQKVLLLCFLLTTMGCASMAMIGYLMFGADIESQITLNLLVNKENSKLAIYITLVRKFYCMYII
The following text describes a protein:
Function:
Transcription activator that binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3' (By similarity). Regulates transcriptional activity in response to calcium signals (Probable). Binds calmodulin in a calcium-dependent manner (By similarity). Involved together with CAMTA2 and CAMTA3 in the positive regulation of a general stress response.
Subcellular Localization:
Nucleus.
Sequence:
MSSVAEDNSFTCDIATIFVAICRNPPANPSDSLFQYEISTLYQEAHSRWLKPPEVLFILQNHESLTLTNTAPQRPTSGSLLLFNKRVLKFFRKDGHQWRRKRDGRAIAEAHERLKVGNAEALNCYYAHGEQDPTFRRRIYWMLDPEYEHIVLVHYRDVSEREEGQQTGGQVYQFAPILSTQNVSYNQYIGDSSDIYQQSSTSPGVAEVNSNLEGSASSSEFGQALKMLKEQLSIGDEHVNSVDPHYIQPESLDSLQFLEYSDIDHLAQPTTVYQRPENNKLERCYGGNFGAQYSAKNDSNKLERCYGGYVGGAEYHSSNLMLVKNGSGPSGGTGGSGDQGSESWKDVLEACEASIPLNSEGSTPSSAKGLLAGLQEDSNWSYSNQVDQSTFLLPQDLGSFQLPASYSALVAPENNGEYCGMMEDGMKIGLPFEQEMRVTGAHNQKFTIQDISPDWGYANETTKVIIIGSFLCDPTESTWSCMFGNAQVPFEIIKEGVIRCEAPQCGPGKVNLCITSGDGLLCSEIREFEYREKPDTCCPKCSEPQTSDMSTSPNELILLVRFVQTLLSDRSSERKSNLESGNDKLLTKLKADDDQWRHVIGTIIDGSASSTSTVDWLLQELLKDKLDTWLSSRSCDEDYITCSLSKQEQGIIHMVAGLGFEWAFYPILAHGVNVDFRDIKGWSALHWAAQFGSEKMVAALIASGASAGAVTDPSRQDPNGKTAASIAASNGHKGLAGYLSEVALTNHLSSLTLEETENSKDTAQVQTEKTLNSISEQSPSGNEDQVSLKDTLAAVRNAAQAAARIQAAFRAHSFRKRKQREAALVACLQEYGMYCEDIEGISAMSKLTFGKGRNYNSAALSIQKNFRGYKDRKCFLELRQKVVKIQAHVRGYQIRKNYKVICWAVRILDKVVLRWRRKGVGLRGFRQDVESTEDSEDEDILKVFRKQKVDVAVNEAFSRVLSMSNSPEARQQYHRVLKRYCQTKAELGKTETLVGEDDDGLFDIADMEYDTLFSLP
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MADLQARVQEFVNPELPGEVHNAALTEILDAVRQERLSVPQLVGSLAEQLTTEDNGIRARACQLLAGVIKGIPDVPLQDTAIHSLAEFFASRLADFPSLRGALTGSLALLKRTPEVGALHPTDAVEIAKAVLNSVHVQSLTAVDRLLSFEVLETLIESHPSAVLALEGDFLDGLVAAIDGEKDPRCLLLAFRLVEIAPKVFVTGQSAVLAEAAEELFEVIAVYFPVSFNPPPNDTRGISREDLVVALERALAATPLFAPYSLPLFIEKLGSSLTSAKLDSLRALRACAQSYGSAIASQTGPLWTALKNELLPLSVEASSAGEVGPVPERSAEVGDAAVEALTQCVRALEGVGRGAPAVSNPLVRSVLEDPTLGDLFIAATGETSIPLTKLLNHGGQSTHSQTDPHLDESQPRPVLHQTVSQALSAAPHDSEGQARRREAVERWSGVLSAVATAGAGPCRQVAEAVMARVTSAGSVGYTGLRLLSKLAGAARTLVWTGQGDVSRGFEGGTGRELDAEEVLGGKAEALGEIFSGVVRAWQAEGGVPDGELNDLATLAVDGLEALASLPPPLSQAESNPLRQNCISVLVSVLFSPGSDPHTPNPLQQKALQALASISRGPPSKEPPGTAEPNTGVTRGEVGDSWHGARQVWAAVSERLLQGSASQGFSLQIFATLAESSGVINREVLQALERQLDRLWGAVGGSVESESEAVEVLRLLAREILPKFGSDESDQELVLHFVHALLERLATWPSPRRPNDGLLAAALGALCVAMRICTEANQAALLQKAAGGFFQALEGDGVWRSGPVLAILVALRPSVSAEAGQPRVLQGLLSLALQSSDALIADAASVALASLLKKWPAQSVRHVAAQETSLSAFHAGGASDQLDQGGGTEAEPEGRFENVSTRPYSEEANSPHETRLPATSTPSDTALRTQTLGQPFVPFGVSTPPHGQPAARMTPSPVTPASTQALPSVSPPSSAATSDYSPAIFLDSSPQSVLFDTTPVSILQPGFSPAGGLPGPSPDPPGTTAVFRAPSPGDIPPRARRVAQRLDLSRLGGAVAASNTAPRGPEPTNPPERSPQKLAGGDGSLDLESALRVVLDERLLPLLPESTTETGQKGLEAQIRGVRVLAVVGQALAMRGHKRTGDVVGALVQLLFTLGKAHGTAGGVNASSGGSGKADGRGGPGEGARNGMPRVSAATLSSFQPEAHTSRSTGESLSPSAGSPQDDQPSASYDLAGLAQLADVAAEGFGVIAGERRSSNPAESSTDLNLSKETHAQIKPLYRQRLFTMSLGPFSEAVRKAKNPEERLPLYRGLAHLLRGTPPAALAVEAEKVLLLLLESLSALAASSDVRAPRPASDAPLVLSDLLTLTSFLTDGGPAREHASEHVPSIVRTLVRLTAYGLSASVRETALQALVAAADLPFTRVYPLRNEVHKAILGALDDPKRAVRKEAVRCRRVWTALGSSKK
The following text describes a protein:
Function:
May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSFFKFYKASLQSHPKRTNALTTGFLFGLGDIVAQTQFPEPGASYDPMRTLRPFLYGAVLFSLVGDKWYRFLSTVRLGRLPQAHWANVLARVACDQLIFAPIGVPLYYTAMALMEGGSLEDVRIRLSEKWWSTLLANWIVWPAFQLCNFSLVPVQHRLLTVNVLSIFWNTYLSYSNSTASS
The following text describes a protein:
Function:
Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Not essential for viability, while oxa102 is essential. When both genes are deleted the cell is non-viable, suggesting that oxa101 act as a back-up for oxa102.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLHFLIRPSTRCAGSPHFNSTSSFLRKRLQSKTILSKRLGFQFRPSSTNVLAEVSTATSGFNPSWWPYALIQNTAYTINVYAGAPWWVSIILTTLGVRLALTPVMIASFRNSTKLSVIQPEMKKELEAIKTAKLDNDQLALNQHSIALRGIYLKHNVNPFAIFILPLTQSAVFFSFFYAIRKMSRLSVDGFTTGGLAWFKDLSIPDPYCILPIINAGLMFSGMQMNRANTASTIGNSTNWRTFFFLCCLLSPLLTAKLPAAIFMYWIPSSLFNIVQGYILKNPVVRSKLGFAPLPSIIEKQPSGFTLITNPIKSLKEFYKGVRDGFKTQYEQLQKDVSRRAVATTSASTIRPNSHYKKLKELNRSKKNSKKQSN
The following text describes a protein:
Function:
Involved in pyrimidine catabolism. Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously. RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions. In vitro, can also deaminate 2-aminoacrylate.
Miscellaneous:
MISCELLANEOUS: This reaction can occur spontaneously. Under standard laboratory conditions, a Rut pathway lacking RutC generates sufficient nitrogen from uracil for growth of E.coli; MISCELLANEOUS: The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function).
Sequence:
MPKSVIIPAGSSAPLAPFVPGTLADGVVYVSGTLAFDQHNNVLFADDPKAQTRHVLETIRKVIETAGGTMADVTFNSIFITDWKNYAAINEIYAEFFPGDKPARFCIQCGLVKPDALVEIATIAHIAK
The following text describes a protein:
Function:
May overlap in function with tropomyosin and may be involved in organization of actin filaments. Acts as a multicopy suppressor of RHO3 mutation. RNA-binding protein which may modulate mRNA translation. Involved in heme regulation of HAP1, as a component of the high-molecular-weight complex (HMC).
Miscellaneous:
MISCELLANEOUS: Present with 8430 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Note=Associates with translating ribosome.
Sequence:
MSAETAAANTATAPVPEVQEQESSKSKQVNLTPAPLPTSSPWKLAPTEIPVSTISIEDLDATRKKKNRTPTPKSSTATKWVPIKASITVSGTKRSGSKNGASNGNSNKSKNNKTAASSTSSSNANRKKKHHQHNAKKQQQMKKDGFESAVGEEDSKDATSQENGQSTQQQQPPHHRNHHHSHHHNSNGPQRRKFHNSNNAGMPQNQGFPPQFKPYQGRNARNNNNNRSKYHNHFHHNQQHPQQPMVKLQQQFYPVQPVLMAINNIARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVVNMSFGGDTNLILAALREIVANEAATVNVAEGTLAAKEGDNVTGEAKEPSPLDKYFVRSKSWSNWLPETFETEINIEKELVGDALDQFMISLPPVPQQEEESSTELASQEQETKEDSAPVAAGESESSL
The following text describes a protein:
Function:
Galactosyltransferase that adds one galactose residue in the beta-1-4 linkage to GlcNAc-alpha-pyrophosphate-lipid in the biosynthesis of the O-polysaccharide repeating unit of the O antigen.
Sequence:
MIDNLIKRTPEINRLLENKRVTGVVTFVNPYSYYKIKEYNKISQLDYIYIDGILLLKLFNFVNGTKIKRHSFDYSSIAKTVFNYSIQNKMKIGLIGSKDYEIEQAVKNIRKKHPGIDISYFHSGYFSSLEEKSSVIDSVIKKSDIIICGLGTPAQEELALDIKIKSNEHLIFTCGGFFTQTASRADFYYPWIKRYNLMWLQRIVLYKHVRKRFFIDYPKFIVRFISENLMKIFTRSN
The following text describes a protein:
Function:
Dynein-attachment factor required for cilia motility.
Subcellular Localization:
Cytoplasm. Cell projection, cilium, flagellum.
Sequence:
MSSTPDHRPSKVSKELANAACDDFKRKAIDEAKKRAVAQRVDYDTFKNMVLTAHLKPITAPKQLNNDRPLPCWSFGVDGKMLKEQISQSQLPPTTPTEVPTTSGDFTRDWRRNCPTPDDKYRYLKLCGPEGLQAVFRVEISAEVLREMLAVLEACWLGHGGVAEEAEGGAGAALLEAAFVVQVLEAVSTAGRFSLTVKLLGSSAKPTLERLFSGLQSAVLASQAAHQGKQEQPAAAEAPHEEGGSTVDPCSPTRVAALQAMYGLPPS
The following text describes a protein:
Function:
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing (By similarity). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper cells. Required for CD28-mediated differentiation of T regulatory cells (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle. Note=Colocalizes to dynamic vimentin filaments both in the central cytoplasm and at leading edges of migrating cells. Colocalizes with F-actin, Arp2/3 complex and cortactin to leading edge lamellipodia, ruffles and macropinosomes of migrating cells.
Domain:
The N-terminal leucine-rich repeat (LRR) domain is necessary for localization to vimentin filaments. The C-terminus is necessary for localization to the cell membrane.
Sequence:
MAQTPDDISCELRGEITRFLWPKEAELLLKTWLPQEGAEQSHILALLRWRAYLLHTCLPLRVDCTFSYLEVQAMALQETPPRVTFELESLPELVLEFPCVAALEQLAQHVAAAIKKVFPRSTLGKLFRKPTPSSLLARLERSHPLESTIPSSPCGGFLETYEALCDYNGFPFREEIQWDVDTIYHRQGCRHFCLGDFSHFGSRDLALSVAALSYNLWFRRLSCEDMKLSLEVSEQILHMTSQSSYLEELVLEACGLRGDFVRRLAQALAGHFNSGLRELSLSGNLLDDRGMRALGRALATNATFDSTLTHLDLSGNPGALGPSQDSGGLYTFLSRPNVLAYLNLAGTDATLGTLFTALAGGCCSSLTHLEASRNIFSRMKSQAAPAALQRFLGGTRMLRHLGLAGCKLPPEALRALLEGLALNTQIHDLHLDLSACELRSVGAQVIQDLVCDAGALSSLDLSDNGFGSDMVTLVLAIGRSRSLKHVALGRNFNVRCKETLDDVLHRIAQLMQDDDCPLQSLSVAESRLKQGASILIRALGTNPKLTALDISGNAIGDAGAKMLAKALRVNTRLRSVIWDRNNTSALGLLDVAQALEQNHSLKSMPLPLNDVTQAHRSRPELTTRAVHQIQACLWRNNQVDSTSDLKPCLQPLGLISDHSEQEVNELCQSVQEHMELLGCGAGPQGEVAVHQAEDAIQNANFSLSILPILYEAGRSPSHHWQLQQKLESLLGQVGEICRQDIQDFTQTTLDTTRSLCPQMLQTPGWRKQLEGVLVGSGGLPELLPEHLLQDAFSRLRDMRLSITGTLAESIVAQALAGLHAARDRLVERLTQQAPVTMAPAVPPLGGNELSPLETGGLEELFFPTEKEEEREKVLLRKRNGTPSWQLRGKMQSRRLGRLHAVAEKHWAAGPRDTPASAVYQRVDVCVGWVPPALLQEGNGLTARVDEGVEEFFSKRLIQQDHFWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRPDLETSPGAAARARKSTLGDLLRPPARPGRGEEPGGAEGGTSSPDPARRNRPRYTRESKAYSMILLPAEEEAAVGTRPDKRRPLERGDTELAPSFEQRVQVMLQRIGVSRASGGAESKRKQSKDGEIKKAGSDGDIMDSSTETPPISIKSRTHSVSADPSCRPGPGGQGPESATWKTLGQQLNAELRGRGWGQQDGPGPPSPCPSPSPRRTSPAPDILSLPEDPCLGPRNEERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGSKPLPPYPTEPSSPERSPPSPATDQRGGGPNP
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MANRFTSSDQTQETHGHHVDKHSFSGRQRHPSMGVHSFNEYMNEYPEAGPLVQEEEDDMESSSYHATQEDIGDDDSRSESTRNRSSQHTGRVNFSSLGGLGSIFGGKKSRSKSANGTQKKNANNNEEQLDEEEQNDPYLDRDISLLGSTI