lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MTSASIHIGSYTSTTNGNTTVVKAPTKESLSTCLSATATTTSPLDSIDIYINTSDLPTHYDSLALASIVPSLSPGGVLSVHVVSASSSAASNESAAVDVVNWSAITTSFVLAGLKAESEQRDGSGGRVYTARKATASQSASSAAATGRINLGGAKTKVKLSLDDDDDDQLIDEDDLLNGGGGMLAPPPTIDTEARAKSNLDDCGGRKACDNCTCGRAEQEAADAAGGPNEQQSKSSACGNCAKGDAFRCAGCPYLGMPAFKEGEEHLVLKLNDDV
The following text describes a protein:
Function:
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. MSRB family specifically reduces the MetSO R-enantiomer.
Sequence:
MRSMFGSRGPARAVHAKAGSDGQASTSGRTALPRRVILGAGLATALVAVPLLATAPDSRAAAAAAGGIDLEKRLGEVRYSEAEWRERLGPAAYDVLRREATERRWTSPYNFEKREGVFKCAGCDSPLFNASAKFESGTGWPSFFQPLPGAVTEVSDYSIIFMPRTEVRCRKCQGHLGHVFDDGPAPTGLRYCMNGLALSFEPAPGA
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAASDRTVLQFSSSSSSSSQILSAKVHPLVIFNICDCYVRRPDQADRVIGTLLGSVLPDGTVDIRNSYAVPHNESIEQVALDIEYHHNMLISHQKVNPKEIIVGWYSTGLGVTGGSALIHEFYSREVPNPIHLTVDTGFTNGAGTIKAYVSNNLSLGERQIAAQFQEIPLDLRMVEAERIGFDMLKATAVDKIPSDLEGMEASMQHLLVLIDDIYKYVDDVVEGRVAPDNKIGRFISEAVGSLPKLSPSVFDKLVNDSLQDHLLLLYLSSITRTQLSLAEKLNTAAQIL
The following text describes a protein:
Function:
Probable component of an ion channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEAAPGTAAAAAKPAKSCKKYRMGKRHANIYTYQEPPHSNSDEDISEEKADSQDPEQVFQNIQYQKEVMSNIRCRPWPMRQKLRVLRQAKEIVLKYEGRLTRTRGYQAAGAELWRKFLRLAYNFVVLFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFVVLPELLAGAPFGSTVSKTIRQEDLKTAQDLDTIWSLGGYLQYSVLFYGYYGSDRKIGKAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSRMSLASASDENYTFCWRLFCAWDYLIGNPEAAESKAAAIVNSIREAILEEQEKKKSKNLAVTISLRIIANILVLLSLTGSIYIIYFVVDRSQKLENNKRELTLWEKNEVSVVVSLITMIAPSAFELVAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNSMSVTNSIYSIYQVSNNSTPSSATGTPAKEDTLSATISDAQMNSSESHAQSLPTAGSLVNNTASSNSAQNQCWETYVGQEMLKLSIIDMIFTVASILLIDFFRGLCVRYLSDCWCWDLESKFPEYGEFKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAMLLFMLFLCMLPTIFAIARYKPSLSCGPFSGQEKIYDIVSETIQNDFPAWFNSVIAYISSPVVVLPALLLLFMLIYYLQSIARSLKFTNNQLRMKIQAERTEDKKKVVQMAVGQNLVDIPDDQIMSDFTQNSEGTRFQSLDGSDKRPDKDGGLISQESSVRASTPRKNGSVLNFESPVSKGTRIQTISQTVPHAVPSTDVARPVNTTPTTSASLTPAPSVSSAQKPRNDHTTNRYPSVVHGSASELCKTKPYTPVTFKKRIGDVHSEPLFRKSIRQVNPDAFGAGAPVFVGRRPHATRYFIVNENEPRKKSARSTSRLQRQFRIEEPEDIVELYPCNVRRYVVQTPQCMYSPHPSEDEEDEEALGRHYVKRSHRPRSLSDLRPAPRFYIGDRADGHVLTSKVHYKSWDDGFELDLDRPPYAYKKVHLKNVEADQHYLEPQVKPKTKHMLEQSLTESDSVSIESSSDPQNSSNDQYIQVIHSKEKYLKPGTKLTKKKSNTNIELNMSEPNELVCSNV
The following text describes a protein:
Function:
Involved in uptake of extracellular oxidized copper under copper-limiting conditions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQVEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEWNAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVFFHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIRETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFTGHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSPWALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTRKQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSISPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQDQNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB30.
Sequence:
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAARAAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP
The following text describes a protein:
Function:
Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MLFSNNKIHAEGKLALIVGASQGLGADLALKLYQQNCSVILVARTETKLVAQIERIQSSSPENNATLSYKCCDASNYEDCVKLWNDLIVDQKQDPDFIFCCAGSSIPKLFSDLTAKDFAIGINTNYTTSLNITHTGFKQVLGQFSDLSCDQYKKRHVIFVSSVVSFYPFIGYSQYAPLKSAIQSLSIILRQEMGPFNYRVSCVFPGNFQSEGYEEEQKTKPSITKSIEGSSKPISGEDCADIILNQLNRGYDTVTTDFIGWLLGCSVLGVLPRSWGFFQVIVSFIFSIIAPIANYVVYRDVLKFFKTRSTREVEEYEIVSTDDNKKTL
The following text describes a protein:
Function:
Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression.
Sequence:
MDQLRTFIAAADEGSFSAAGRKLRRAQSVVSHTLANLELQVGFALFDRTGRYPVLTDAGQALLEQARNAVGSMDAFKARARTLAEGLEPELAVAVDVMFPIANLTAAVQAFQKQFPTTPLRLYVEALGAVIQPLLAGQCRLAVIGSLPEVPPDCQSEYLLDVPAVTVVAPGHPLAARRGMILRSVLEQHVQLVLTDRSTLTAGRNFGVVSPNVWRLADLGAKHA
The following text describes a protein:
Function:
Required for maturation of 30S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MEENNQIVEKITRIVNPFIEEMNLSLVDVEYVQDGGYWYVRIFIENLNGDLNIEDCSKLSSKIEDKVEELIEHKFFLEVSSPGLERPLKKLEDYTRFIGEKITLHLKHKLDDKKQFKTIIKEVNGDNIIFLMDKKEVEIKFNEIRKANILFEFNDF
The following text describes a protein:
Function:
A secreted aminopeptidase. Acts on free N-terminal amino groups with a very strong preference for Leu- followed by Met- and Ala-, and no activity on Glu- or Gly- peptides (an exhaustive analysis was not performed). Both the AP56 and AP28 forms have activity.
Subcellular Localization:
Secreted.
Sequence:
MSNKNNLRYALGALALSVSAASLAAPSEAQQFTEFWTPGKPNPSICKSPLLVSTPLGLPRCLQASNVVKRLQKLEDIASLNDGNRAAATPGYQASVDYVKQTLQKAGYKVSVQPFPFTAYYPKGPGSLSATVPQPVTYEWEKDFTYLSQTEAGDVTAKVVPVDLSLGAGNTSTSGCEAEDFANFPAGSIALIQRGTCNFEQKAENAAAAGAAGVIIFNQGNTDDRKGLENVTVGESYEGGIPVIFATYDNGVAWSQTPDLQLHLVVDVVRKKTETYNVVAETRRGNPNNVVMVGAHLDSVFEGPGINDNGSGSAAQLEMAVLLAKALPVNKVRFAWWGAEEAGLVGSTHYVQNLAPEEKKKIKAYLNFDMIGSPNFGNFIYDGDGSDFGLQGPPGSAAIERLFEAYFRLRGQQSEGTEIDFRSDYAEFFNSGIAFGGLFTGAEGLKTEEQAQKYGGTAGKAYDECYHSKCDGIANINQDALEIHSDAMAFVTSWLSLSTKVVDDEIAAAGQKAQSRSLQMQKSASQIERWGHDFIK
The following text describes a protein:
Function:
Probable transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEIVKTIIPHNRSYIEPPIPSATEWLANMSVMHVSCLTIACVFVAITFLSSFFHLFFVLKYVSNERIRNDMYALIFMFPITTFASLVGMFIPRAAIFLYAVSLVYFMFTLFIMVTLLFNIFGGRQEMSAYLLQRNIRVNFTVPPLCFFKFLPTVESTDQNLRRIEWLVFQTPIIRTLLELVSVVVSMEQEGRRESVWFVFSQLMALLSMCIAFYGCYVMVPLGREKHAPYRFDFLFRTCDIAQCIYTIQKFVFEFAAAVGLITSDRYLPAAAKALWWASFMCTWEMMLLSALCSYCLRPAKCKFFDLYPGNDMPALSARDGSNSRVPSFSRRLSIEYEPRIAGVMLEPPSRSSLSITPRDKIEDPTTVSYFADNFDSLSQIQGQ
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAAASIYPTLDQRPVKNTIVLFDVDDTLTKPRQLVKPEMLQLLSELRHKVAIGFVGGSNLVKQQEQLATANVNVTSLFDFCFAENGLTAYRLGEELPSQSFISWIGQEQYNKLVKWDPALHRRPRHPRQARHLRRVPQRHDQRLAHRPQRLRPRAQRLPSLRHRAQHPPHHGRRAQESLPRPRPHLLHRRTNLLRRVPHWLGQDVLLEARCRGEDAQWRCVRQDSLLW
The following text describes a protein:
Function:
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences.
Subcellular Localization:
Nucleus.
Sequence:
MAASILEVGSIIEDTRYGSSPLAMLTATCNKFGSTSPVRDSATPDKTGSTTQVKKPYAMASDLQTAKIGRTTDASGLADSYTGSFTTAGGGGGGLLTPSGSPPSSAGGYSTEYNPFSHSFQTSVSQDPSLLVSKAHATADCLSSVYTSLDMTHPYGSWYKAGIHPGITSAPANSTSSWWDVHPNSNWLSATQPQTDGGLQASLQPVAPQASLSPQLPSYSTDFTTLNPAPYPSVGLGSSSHLLQPSQHMLPQDMYKPKPVPSTGLIESPMGLKPARGSGGYSGGGTPGRSSCDCPNCQELERLGASAASLRKKPVHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCNKRFTRSDHLSKHQKTHADSAMQGKAGAVEGDTDPRGEDTPELNSSTAPANPATDQITGGEEKTGTPNGVENSSGLLEI
The following text describes a protein:
Function:
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Sequence:
MAKIPVLEIFGPTIQGEGRVIGRKTMFVRTAGCDYRCSWCDSAFTWDGSAKGDIKLMTAEEIYDELKRIGGDLFNHVTISGGNPALIKGIQELVDLFQDKGIFSALETQGSKFQPWMTQIDDLTISPKPPSSTMTPDLKKLDEVITQCVPSSLNLKVVVFDDKDYDFAKMIHHRYPDIPFYLQVGNPYLSDSVDNHTEKLLERYEQLVDLVMQSNDMNHVYVLPQLHTLLWSNKKGV
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MEEVSRLRTLVDNISSYLSISSSTNKLFSNPAHKYYSRGEEIAKLLMPFLDNLVASDASPNEFLNNGFEELSQYIDELREQFESWQPLSSRIFYVLRIESLASKMRESSLEIFQLLKHLPGDLVSEDCIELVKLVGREEVSYTIDRALIDQRKGVELTPEVLLKIAESVGLRSNQDILIEGVVLTNLKEDAKLVKNNIKAGFIKGLMYLTKQMHDYLAKIEQSQLPSDFFCPLSLQLMTDPVTVASGQTYERAFIEKWFDTGLMVCPKTRQALSQTTLTPNFTVKAFIANWCESNNVNPPDPLELIQSNQPFPLLVGSGSRGSLPLPVMDDTLKCNHTESVDASKCEELHQVLTRSASAPGIVSKVVSKANRSILQAPVETVPQPCIIPATIKETGSSSNMEAEETGGSSSMEVEVKKLIQDLKSSSLDAQREATAQLRLLTKDIPDNRTVIARCGAIAALVNKLYSMDKMIQADAVTCLLNLSLDDSNKTVIAYSGVFKPLVHVLKTGNMEAKENSTRALVSLSKAEENRTKMLEAGAIEPLVRLMGNGSPRGKKDAATALTNLATRNKEKEMVIRGGGVRYLIQMMNPAAGTVERAVVVLANLANVPEAKIAIRDGGGIPLLVEVVELGSPRGQENAAAALCLLCMDSSRFCNTVIREGAIPPLVALTRSGTARAKEKAKSLLKYFEALKQENQRRS
The following text describes a protein:
Function:
Catalyzes the transfer of short (four to five carbons) branched acyl chains to the furanose ring of di-acylsucrose acceptors to produce tri-acylsucroses such as S3:15 (5,5,5), S4:17 (2,5,5,5) and S4:24 (2,5,5,12) acylsucroses.
Sequence:
MASSTIISRKMIKLLSPTPSSLRCHKLSFMDHINFPLHSPYAFFYPKIPQNYSNKISQVLENSLSKVLSFYYPLAGKINNNYTYVDCNDTGAEYLNVRIDCPMSQILNHPYNDVVDVVFPQDLPWSSSSLTRSPLVVQLSHFDCGGVAVSACTSHTIFDGYCLSKFINDWASTARNMEFKPSPQFNASTFFPLPSETNLSSTLPATRPSQRHVSRMYNFSSSNLTRLKDIVTKESHVKNPTRVEVASALVHKCGVTMSMESSGMFKPTLMSHAMNLRPPIPLNTMGNATCIILTTAMTEDEVKLPNFVAKLQKDKQQLRDKLKDMKEDRMPLYTLELGKNAMNIIEKDTHDVYLCSGMTNTGLHKIDFGWGEPVRVTLATHPNKNNFIFMDEQSGDGLNVLITLTKDDMLKFQSNKELLEFASPVVESTK
The following text describes a protein:
Function:
Involved in organellar RNA editing. Required for the processing of numerous RNA editing sites in mitochondria. Binds to the mitochondrial MEF19 and MEF21 factors, two pentatricopeptide repeat-containing proteins involved in RNA editing.
Subcellular Localization:
Mitochondrion.
Sequence:
MAMISHRLRRALLTATSYVNRSISSSITPASDFPSVSAAVLKRSVIGRSTEVATRAPARLFSTRQYKLYKEGDEITEDTVLFEGCDYNHWLITMDFSKEETPKSPEEMVAAYEETCAQGLGISVEEAKQRMYACSTTTYQGFQAIMTEQESEKFKDLPGVVFILPDSYIDPQNKEYGGDKYENGVITHRPPPIQSGRARPRPRFDRSGGGSGGPQNFQRNTQYGQQPPMQGGGGSYGPQQGYATPGQGQGTQAPPPFQGGYNQGPRSPPPPYQAGYNQGQGSPVPPYQAGYNQVQGSPVPPYQGTQSSYGQGGSGNYSQGPQGGYNQGGPRNYNPQGAGNFGPASGAGNLGPAPGAGNPGYGQGYSGPGQEQNQTFPQADQRNRDWNNNNPAGQPGSDQVRSRSIMNLASFFFDILIRH
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MMLRSSRRILQAVSSLAEENLSYRLLETLRKPPCFLSTTATRSSSQSTNSTTEESRSGAEPSESENCSELEAKLAKKDKYIEERDKLVTELEDKYKRSLAENQNVLQRSQKMVEEARLFAIRGFSKDLLEIADILEKATTSVPKEELDKNSHLKNLFEGLTMTEAQLHKVFNKNGLEKMNPEGEKFNPHFHEAVFQFDAPDKEDGTVAVVQKIGYTLNGITLRPALVGVVKKST
The following text describes a protein:
Function:
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Subcellular Localization:
Cytoplasm.
Sequence:
MISIKVLFFGEACQLVGKREEAIDFPEETDYEEIRKTILENYPALQKIEKVMMLAVDQEYANPGDRFELVRFTEIAVIPPLSGG
The following text describes a protein:
Function:
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Sequence:
MFNSSTQLKNWTFEHEEELIKLRNNANTKYRTSYCDVNNHVTPDADTFFLTVSEHCFLVQHYERKLQEICWKFKPPMPLNVVGTSCMYLKRLNLRKSVMDYHPRLMHLACIWLACKTEEFNISMDQFVQQVAHGNEEIGDAILTIELILIQELNFHLTIHNPFRPLEGFLIDLKTRYRNLENAEQLRKPAKDFLVRSLNTDVGLLYAPSQLALAALLSAASMRNLNIDRYVTSVLLVGQPQTVLEQTIQRIKKIRTIVKNAVSAPLPSDQIEILEQKLSHCYNKEKDPTSYEYSCLQQEIESQKYDKQTKKRKLEHERRRKIETELLGF
The following text describes a protein:
Function:
Ligand for the EGF receptor. Seems to play a role in the global proliferation of wing disc cells and the larval patterning. Shows a strong synergistic genetic interaction with spi, suggesting a molecular interdependence. Required for the development of interveins cells.
Subcellular Localization:
Secreted.
Sequence:
MYAQHLRKWSLKTKKQLMPLILLIISYMLLLNTCVLSSSATTQQQQQQQQQQQHLPRLWEGSAEESSYYIPLSSDNGSGSSESSAESGSSSSRSSSNNIDNNILSRLLSLNSNSLSSRSNVKLKPATVFDAGSSTPAQQEQHVAAVPEQQQQQQQQQQSMQKVPNTLINSQIYNLLYNGMPSEAASSKMRRHIQPSQLPHQPESRAQLPSNYSSRPAVRSYLIESYEMPESMLEDRSPEQAARSRRDGSNTNGSRQQQRTGHRQQLQQDKRDHRRQRQDQQKEQRQQQQQRQHKSGNKHQQQQQQRRKHQRKHQRYNRYCSARDPAQLAFAAPTVFQGVFKSMSADRRVNFSATMKVEKVYKQQHDLQLPTLVRLQFALSNSSGECDIYRERLMPRGMLRSGNDLQQASDISYMMFVQQTNPGNFTILGQPMRVTHLVVEAVETAVSENYTQNAEVTKIFSKPSKAIIKHGKKLRIVCEVSGQPPPKVTWFKDEKSINRKRNIYQFKHHKRRSELIVRSFNSSSDAGRYECRAKNKASKAIAKRRIMIKASPVHFPTDRSASGIPCNFDYCFHNGTCRMIPDINEVYCRCPTEYFGNRCENKWPDSRYFVAIYGQIHTLNNDY
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEISESTKVVFYVSRIFGLAPYVVKRTPIGQIVDYKRSVFLIAYSVGLVFCLAGLTYKGIFFDVTSKKPIRMKTATSKVVTILDVSVVVSACICGTLSGIGGLHFVRELNRRLTEADEILSLYVKESTRSRRQRRKGILMLGLVCFIITGALSLDIWVWYRIADKIKKENSNSSANVLGYFPFYCLYYILMMFHVLFAQAALGIGNRFRHLNVALYEMFPEFGRTPRIEISSINLDSDKNDPIDVDLRKCVANVAHGFDRKRTLSSRKIIEDLAVIHASLSYCIVLVSKTFGIALLAVLGSCLLHLVATSYFLMVELVGDKDAVFAWIQALWLFIHIFRFLLTIEPCHITNVESNRTITIINSLRRTCKDVEMIESINMFWQQLIASNFSFTACGLCTIDRRIITSYCGAIATYLVILIQFKEADDNSGKTPH
The following text describes a protein:
Function:
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRDVLSITDLSKEEIYELLESAADLKAKRKAGESTEYLKNKSLGMIFEKSSTRTRVSFEVAMTDFGGHALYLNSRDIQVGRGETIEDTARTLSGYLHGLMARVMSHDTVEKLAKYSTMPVINALSDREHPCQILGDFMTIMEFKKKFEGLKFAWVGDGNNVCNSALLGSAIMGMEFAVACPKGYEPKAEFLEQAKALGGKFTITDDPKVAAKDADIIYTDVWVSMGDEAEQEKRLREFASFQVNTELLGVAKPDVIVMHCLPARRGLEITDEVMDGPNSVIFEEAENRLHAQKALILKLMR
The following text describes a protein:
Function:
Endoribonuclease that plays a central role in RNA processing and decay. Plays a major role in pre-16S rRNA maturation, probably generating the mature 5'-end, and a minor role in pre-5S and pre-23S rRNA maturation. Probably also processes tRNA (By similarity). RNase E and HupB jointly contribute to cellular adaptation to changing growth conditions and survival during antibiotic treatment and in the host.
Subcellular Localization:
Cytoplasm. Note=Has dynamic expression patterns, often present as foci near the mid-cell or new cell pole in addition to a weaker overall cytoplasmic distribution. About 60% colocalizes with HupB and about 25% with ribosomes.
Sequence:
MIDGAPPSDPPEPSQHEELPDRLRVHSLARTLGTTSRRVLDALTALDGRVRSAHSTVDRVDAVRVRDLLATHLETAGVLAASVHAPEASEEPESRLMLETQETRNADVERPHYMPLFVAPQPIPEPLADDEDVDDGPDYVADDSDADDEGQLDRPANRRRRRGRRGRGRGRGEQGGSDGDPVDQQSEPRAQQFTSADAAETDDGDDRDSEDTEAGDNGEDENGSLEAGNRRRRRRRRRKSASGDDNDAALEGPLPDDPPNTVVHERVPRAGDKAGNSQDGGSGSTEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFLARREAVERVMVVRDRVRTEPPLPGTRYTQIAVLEDGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYAGEVNWDAAGLGGADRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLAGRFLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEDDIRADVARLRERWEQIEAKAQETKEKAAGAAVALYEEPDVLVKVIRDLFNEDFVGLIVSGDEAWNTINEYVNSVAPELVSKLTKYESADGPDGQSAPDVFTVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGAGGNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTESLARDRTRHQVSEVTSLGLVQLTRKRLGTGLIEAFSTSCPNCSGRGILLHADPVDSAAATGRKSEPGARRGKRSKKSRSEESSDRSMVAKVPVHAPGEHPMFKAMAAGLSSLAGRGDEESGEPAAELAEQAGDQPPTDLDDTAQADFEDTEDTDEDEDELDADEDLEDLDDEDLDEDLDVEDSDSDDEDSDEDAADADVDEEDAAGLDGSPGEVDVPGVTELAPTRPRRRVAGRPAGPPIRLD
The following text describes a protein:
Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.
Sequence:
MDPLAPLNPLIRGPRIPGLRRTEPGLTRSCRGAFRSPRPSPKSGQADGTSEESLHLDIQKLKEKRDMLDEEISQFISEGYSVDELEDHITQLHEYNDIKDVGQMLMGKLAVIRGVTTKELYPEFGLDMND
The following text describes a protein:
Function:
Inner capsid protein that plays a role in viral DNA ejection into the host cell. Ejected from the capsid after penetration the host outer membrane and has been released. Assembles into a structure that extends the extracellular trans-envelope channel formed by the internal virion protein gp7 and probably gp16. This channel allows the delivery of the viral genome into the cell cytoplasm.
Subcellular Localization:
Virion.
Sequence:
MATWQQGINSGGFLAGIGAQNENAPKARDINATLGLIRENNDLARSGANNVALTGLRGLAGVADIYNQEQQQKALNAFNQVHANAWATGDPSGLFKFAQENPAFVAQAQQAFSGLNEQQRNDMGDLAMKANVALSQGPEAYSKFITDNKDRLNRVGANPDWMIQTGVQNPEQLSHMLTTMSLGALGPEKAFAVQDKMVGREIDRGRLAETIRSNKAGEGLQARGQNITMRGQDMSAATARRGQDLATQRANARTISGSEGNRVVQLADGRTVSVGGKLHGAGANAFYEGIDDNGNMVRVPASAIAAPPTSAASAQNYAMKKDIDAIANADASALDFMTGMTGGAGNPAIGADVRSRLTGKEQRQLYNSAQRIQGRMQNQGVAAARDMGASGINTIAEAKMYFQGMPQVDYSSPEAMQQSIREIQEYTNNYNQQYNVNVGNGGLKSPRQQPDTQQSAGGSYTSKSGIKFTVE
The following text describes a protein:
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
Sequence:
MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDVTDLQVTIEGPEGTPYAGGLFRMKLILGKDFPAAPPKGFFLTKIFHPNVGANGEICVNVLKRDWKAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLDNYEDFDANGDGTLDFREYILALHLTSSGRTRLKLEWAFSLFDVDRNGTVSKTEVLEIVTAIFKMIPPEEQKGLPEDENTPQKRADKLWRYFNKRENDRIAEGEFIEEVMKNEDIMRLIQYEAKKP
The following text describes a protein:
Function:
Histone methyltransferase that specifically di- and trimethylates 'Lys-9' of histone H3 (H3K9me2 and H3K9me3, respectively); involved in positively modulating the rate of age-related behavioral deterioration. May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with probable chromatin reader protein, baz-2. Involved in modulation of the mitochondrial unfolded protein response (UPR). Regulates level of expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase). Negatively modulates levels of endogenous 5-HT and dopamine with aging. Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MERSRTGGSSTYSMSTANVPIITISDDDDELTIWEEPRKSPISSNSYSDERNHSLSSTSNSSVERSIIITISDDESEATERNQQEVVDRAISNNLTEKRRRSVESFHRLHSKERKLEVKSRKKSRTSSSSMEASTSCTFPARQTKTKRHKRKTYSTISSFAPHHSTICAELRNVNPARIADFRHPSIFEYSDMSLNERREHWKKEMKVIKKHNDIRLMHEEAVRFDDIIELDPTLNGYYRRFMGAEQSTRALFMAVRCLATFGRNFYEEPERDHGEEEIPEELDRYFEKLIYVAPRTRIRITDDIHLSNDTHRIPVYTDAKGETLKTVKIPNPLLYDHIINNMVDKVKEPLLYEAIKIAGSSENVIRCKCCSQDPVVNCFDNKDCPCFIANQFLQSRNKTTDTNEKLKFHTFQPLMYNDGNPTYYNTVGFACSPKCACKGACTNNATYLIQKKLYSIEIYRADPQIGFGIRSTLFIPAGTPIIEYCGELVDGERLHSSLENYSYQLTDCEGDKHLYNLLREKYKNNPEYYDVLDELSKHHFHLDAKMQGSVGRFANHSCTPNMEPLRLFKEGFTPANMRMIFFTLKDIFPGEPLTLDYGSEYKVFRRQRCLCRTFACRSGPHYEKFSNLDGKLIASCFVRLHHASRIRYSVDLQLIERFYSVGKVEEVRVDPCVSFSKYNLKWRRQLSTATCERLENVIEIELSDEDS
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Subcellular Localization:
Mitochondrion.
Sequence:
MKCFSISKLTTKSLSLKFPLSLFPNYPASSAVAAAARFPSLSPRSIRFSICSDASRSSRGGVSLSSRDRNLFTMAGADEFVKGNVHPNGVAVITLDRPKALNAMNLDMDIKYKQILDEWESDPKVKCVLIEGSSPRAFCAGMDIKGVVAEIQKDRNTPLVPKVFTAEYSLICKISEYKKPYISLMDGVTMGFGIGLSSHGRYSVVTERTVLAMPENGIGLFPDVGFSYIAAQGPGGGSVGAYLGMTGKRISTPSDALYVGLGTHYVPSGNLGSLKEALLSSTFSEDPDKDLTTLLAKYCSNPESEAHLKLLLPQISSCFSADKSVNETIEEVKKHLQSTEASVAEWANDALQGLGKGAPFSLCLTKNYFSRVASGYGKSGNEFTTLKGVMKTEYRIALRSSLRNDFAEGVRAVLVDKDQNPKWNPPSLNEVNLKDVEAIFEPLGPGIEELKV
The following text describes a protein:
Function:
Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Activates WRKY 22, SIRK and its own promoters.
Miscellaneous:
MISCELLANEOUS: Acts downstream a MAPK cascade and therefore might be regulated by phosphorylation. WRKY 22 and WRKY 29 may provide redundant functions.
Subcellular Localization:
Nucleus.
Sequence:
MDEGDLEAIVRGYSGSGDAFSGESSGTFSPSFCLPMETSSFYEPEMETSGLDELGELYKPFYPFSTQTILTSSVSLPEDSKPFRDDKKQRSHGCLLSNGSRADHIRISESKSKKSKKNQQKRVVEQVKEENLLSDAWAWRKYGQKPIKGSPYPRSYYRCSSSKGCLARKQVERNPQNPEKFTITYTNEHNHELPTRRNSLAGSTRAKTSQPKPTLTKKSEKEVVSSPTSNPMIPSADESSVAVQEMSVAETSTHQAAGAIEGRRLSNGLPSDLMSGSGTFPSFTGDFDELLNSQEFFSGYLWNY