lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the TonB-dependent uptake of copper and iron under conditions in which the concentration of copper exceeds that of the iron.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MVFVECGAALKLNQCIYIGIASTICLLITQKANAQEKPVNTKNIGLITNIPRLSDIERPPTSVKDWLSQSAPTPPKIKITGVRINRTDDNFEIILETPDGEISAPETLQEGNIFIADIPNAVLALPEGKEFREDTPVDGISYVTVTQQESNNTVRVTIASSGKLPPIQVVNQSNGLTIALTPTSPDIELIVTAQKRPEDAQDVPLSLTVIPQQEIEDAQIRSFQDIANNTPNFSFLPTTAGSADFSYYSVRGLNNFNFLANQDTVGFYIDDVPFDYGGFLDVGLIDLERVEVLRGPQSTLYGRSSPAGVVNVISRPPSNQPEMRISALYGSYNNRELQLSLSDAIIPDKLAFRLAGAYNARDGVFDNTFLNKPIGERSQLTGRAQILWTPTPEWNISFNAYASDNDNGNPTFSRQNAENPFQVSQEVDGFHRLSTNTQALKISYNGDGFRATSITTRRFSNQNTLVGDNFPGDLLQQIIGINSTLWSQEFRLQSPESADRLRWLLGGYYESRNFNVLDDTFKYSDAGAVFFGLPASGSDRVSAEQNRHTYAIFGQIDYKPIAPLTLFAGWRYETADAELDRRRVFVNPDGTANPPTAEVRNATLNSDAFIPRFGLQYRFNPNLMAYATIAKGYRPSGFNYRADTEDTRRFQEETTWTYEAGLKSSWLDDRLSANLSIFQSDVDNYQVLLTDDFGFFRNVTNANVKVTGLEFELKANPLQGLDLIAGIGYVDSKFKNYRNSFTNRDFSNNRVPFAPELTYNLAVQYRSPGGIFARAELRGYGITYFDDANQVKQDPYALVNARIGYEGEKYGIYLYANNLFDTRYITSGFLFPPPNVTAGFGDPVTYGVRVSASF
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MALEMRLPVARKPLSESLGRESKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYNGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWVYPTPEHKEDDAGGFIANLEPVSLTDREVISRLRNCIVSLATQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRRLTRRLVLPVFGVLWITVLLFFWVTKRKLEVPTGPEVQTPKPSDADWDDLWDQFDERRYLNAKKWRVGDDPYKLYAFNQRESERISSNRAVPDTRHLRCTLLVYCTDLPPTSIIITFHNEARSTLLRTIRSVINRTPTHLIREIILVDDFSNDPDDCKQLIKLPKVKCLRNNERQGLVRSRIRGADIAQGTTLTFLDSHCEVNRDWLQPLLHRVKEDYTRVVCPVIDIINLDTFTYIESASELRGGFDWSLHFQWEQLSPEQKARRLDPTEPIRTPIIAGGLFVIDKAWFDYLGKYDMDMDIWGGENFEISFRVWMCGGSLEIVPCSRVGHVFRKKHPYIFPDGNANTYIKNTKRTAEVWMDEYKQYYYAARPFALERPFGNVESRLDLRKNLRCQSFKWYLENVYPELSIPKESSIQKGNIRQRQKCLESQRQNNQETPNLKLSPCAKVKGEDAKSQVWAFTYTQQILQEELCLSVITLFPGAPVVLVLCKNGDDRQQWTKTGSHIEHIASHLCLDTDMFGDGTENGKEIVVNPCESSLMSQHWDMVSS
The following text describes a protein:
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSDQNQIKKGEDFEKQAEKKLKGWAFFGSKHEDAADLYEKAANFYKLGKSWDQAGAVYVKLAECFLKLDSKHEAANAFADAGHCYKKTNPTECITRLEQSLDLFMEIGRLGMSARYCKEIAELYEQEQNLEKAMVYYDKAVDLYQGEEVNSSANQCRLKIAQYAAELEQYQKAIEIYEDIAKQALNNNLLKYGVRGHLLNAGICQLCKGDVVAITNALEKYEDLDPTFSGSREYKLLSALAASIDEEDVEKFTDAIKEFDSITKLDAWKTTLLLRVKEMLKAKEMEDDDLT
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MADQVDAGVPDLAGASKQKLEEVMTSQSEHAKQFIDQNFDGMQTLIRNLRTSAFKGLTGFADNLAHRRQVYGSNEMPLARRRSLFHFLLYSMKDWILIVLVIGAIISLVLGLVYPESCKGVINGEVAWYEGVGILVMVVLMILISALSDYLRDADFRCQQKRVHMEERVTVIRDSGAVKDILKSELVVGDLCLLKAGSLVAADGVVVQSSDLVVDETLFSRSERHKSVVDPLVFAGTHVVKGTGKFIVLAVGASTQAMMQLRLGDPASPGIELQPAPAGPINNKGSQNLLEFKRHKEENATLEGKVNRVAVALGYIGIAVALITMIVIMVHFSVTNYYTNEKPAKPEDVNMYVRAFIMGMVVLVVSVPEGLPLAVTFALAFCTKMMYNKQSLVKHMDIIETMGNVSNIYCNKTGVLTEHRMRVDRMFIADQLLDGDPKVYKHKIPSELLDDLFKAISLNTSYSSQIQPAGRDHLPVQVGNKTDCSLLQLMLEMGETYQYWRDDHPEDRFVKVFAFTSERKSMTTVLEKEKDGFYVYTKGAAEILLPRCTSTITTDGKMRPFTDEDRERLRKEVMEEMHKQALKILVLACRSLSDSDKGLLEDEAKVLEDLTLMAVVGIEDPIREKVPEAIWKCDRAGIRVCMVSGDSIQTARAVAARVGILKPDEDILMYTGQEFNSYIRDPDGKVNTDRFNSMWPKLKVLARATARDKYTLVKHVMGSGVNRQGEMVAVTGAGVHDGPVLRKADVGFTMGVSGSDVAKDSADVVLLDDNFGSIVWAIKWGRNVYNTVVKFLMFQFTVTWSAFIVVVIGACVTGRSPLGATQLLWVNLIMDSLASLALTRDFPTDDLLRHQPYGRHKALIGRTLIRNVVGHVIFQLVVMFVLIFKAHEWLDIKDGFQTDTICQPSQHSSLVFTTFVFMQVFNEINSRSVHGRNMFKGIHRNIVFICIWIAQVSIQVLIVEVFTRAFNTKGMDAEQWLWCIFLGLSELIWAQVIYTFPKTWLPLFLRCGVTGHPKGRHINWIRSTSRVDQKDSGPAAAFKLNVADHPPPPATPTGVMPITPEDEHWRGPTAADERL
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSKYEVQEKHKKSQQRKQRKDTYFEDGQRRKDWHDIEAIWKDAKRVGNGEQGKPYPITDAERVDQAYRENGFNIFVSDKIALNRSLPDIRHPNCNSKLYLEKLPDTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMAQFPSVRILRTKKREGLIRTRMLGASVAIGDVITFLDSHCEANVNWLPPLLDRIASNRKTIVCPMIDVIDNNHFGYKTQAGDAMRGAFDWEMYYKRIPIPLELQKPDPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYIPYKIPTGVSLARNLKRVAEVWMDEYAEYIYQRLPEYRHLSTGDVTAQKDLRNHLNCKSFKWFMTEIAWDLPRFYPPVEPPAAAWGEIRNVGTQLCIGTKHGSLGSALRLESCVKGRGETAWGNLQVFTFSWREDIRPGDPQHTKKFCFDSISHSSPVTLFDCHGMKGNQLWKYGKDKTLYHPVSGTCMDCTESDHRIFMNTCNPSSPTQQWIFQYTNSTVLEKFNKNSDL
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Mitochondrion.
Sequence:
MGVSIWRRAFRSSMYPYKTATNNNKRPLNRIDNSNTSTEQQQQQPKPTGKLSSLSRQWSSNEPQPPKNLPSSQPPPQSSSQPSWQLDQEEWPPTPPQPDPPSKKPKPNNNISYPTSAIRYPPQNQNNQKNTLERTTSANKALPWELPAPQNPRNNNQINGSSSSSSSKSVAFNQLQGIGKQNKSDAIIKSHLNNPNMSIAAKVSLSPEQQSVLDLVLKGESIFFTGSAGTGKSVLLRHIIAALKRSYSSRPDAVAITASTGMAACAIGGTTIHSFAGIGLALEPKDILLGKVKRNRKAAGKWMRTKVLIIDEISMVDGELFDKLAYIACKMKKSEKPFGGIQVVIAGDFFQLPPVSKGKVSFAFNASSWSECIPKTINLTQVFRQKDSTFIDMLNEMRMGELTRDSIQRFYKLSRELNFGDGIEPTELYPTRNEVERSNATRLAALKTEARVYAAIDSGKAPPEQRARDLANMMAVPSLTLKKDAQVMMIKNHAGEDGPAWLVNGLVGKVVDFVDPDITPDYLLHQQRTREEAEAVDLSGIFSDDDSDLEIKPRPISSKPSAFPPLRGAAKIEAEAKGLPTTANTSTTPKSNGGLVPLVEWFLMNGKREFTVVKRAEFKVENMDGEVQSRRSQLPLILAWAMSIHKSQGQTLQRVKVDLGKVFEKGQIYVALSRATSLEGLQVLRFDPKKVMAHPDVILWSKNNLVTGSSL
The following text describes a protein:
Function:
Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPPSKKSHPKKSKRDDKLRGASKKPFKPRMRQNEAVPSESLALQMEDDVPDFPRGGGSLLSRQEHDAIRAEVDAEFEAGERKTKKKNKNAKKTKKNYALEDDMGSLFGDGITGKLPRFANKITLKNISPGMKLWGVVAEVNEKDLGISLPGGLRGLVRASEAFDPLFSNEIKDAEGIFLPRIFHIGQLVSCVVLQLDDDKKEKGKRRIWLSLRLSLLHKGFTLDALQEGMVLTAYVKSIEDHGYILHFGLPSFTGFLPKSSQAENIEINTGQILQGVIRSIDKAHKVVYLSSDPDTISKCVTKDLKGISIDLLIPGMMVNARVQSTFENGVMLSFLTYFTGTVDIFHLQTTFPSSNWKDDYNQNKKVNARILFIDPSTRAVGLTLNPHLVNNKAPPCPVKTGDIYDHSKVIRVDRGLGLLLEVPSTPASTPTYVTLFDVADEEVRKMEKKYKEGSHVRVRILGFRNLEGLAMGTLKASAFEGSVFTHSDVKPGMVVKAKVIAVDSFGAIVQFPSGVKALCPLRHMSEFDIVKPRKKFKVGAELIFRVLGCKSKRITVTHKKTLLKSKLGIISSYTDATEGLITHGWITKIEKHGCFIRFYNGVQGFAPSSELGLEPGCNTSLMYHVGQVVKCRVKGSVPASRRINLSFIIKPTRISEDDMVKLGSVVGGVVDRVTPHAIIVNVSAKGYLKGTISTEHLADHQGHAALMKSTLKPGYEFDQLLVLDVEGNNFILSAKYSLINSAQQLPLDLTQIHPNSVVHGYICNIIETGCFVRFLGRLTGFSPRNKVMDDQRAVPSEAFFIGQSVRSNILDVNSETGRITLSLKQSCCSSTDASFIQEYFLLEEKIAKLQLSDSEHSELKWAEGFNIGTVIEGKIHDAKDFGVVISFEKYNDVFGFITHYQLTAERGSTVQAVVLDVAKTERLVDLSLKPEFLDRHKEDSSNSQAGKKKRRREAYKELQPHQTVNAIVEIVKENYLVLSLPEYNYAIGYASVSDYNTQKFAQKQFLHGQSVIASVMALPSPSTVGRLLLVLKSVSEATETSSSKRAKKKSSYNVGSLVQAEITEIKPLELRLKFGIGFHGRVHITEVCDENVIENPFSNFRIGQTVSARIVAKANKSENNGKNHQWELSIKPEMLTGSIEVENKLVDAEFRISTGQRVTGYVYKVENEWIWLTISRHIKAQLFLLDTSCEPNELQEFQKRFEVGKAVSGYVLSANKEKKLLRMVLHQFSVSNGTLDGKVLNIDNQHCNPPIENLIPHIHKGDTLGGRISKILPGVGGLLVQIGPHLYGKVHFTELKDSWVSDPLSGYHEGQFVKCKVLEIGHSEKGTVHVDLSLWSSLNGMHSPNSRVEKIDNLHSDMLVQGYVKNVTSKGCFILLSRKLDARILLANLSDGYVEKPEREFPIGKLVSGRVLSVEPLSRRVEVTLKTSSATSVQKSEVNDFSSILVGDIIFGTIKRVESYGLFITIDDTNMVGLCHISELSDDHISNIETKYKAGERVAAKILKVDEERHRISLGMKNSYIKETTQNNGFVDDTQLSTFLENNSREIQNLDVEYEDEEYPVLSQVESRASILPLEVDLDDVNHSNLDDAVGQNHIYTNETNTIDEKSKRRAKKKAKEEKEQEIRAAEERLMLNDVPRTADEFEKLVRGSPNSSFLWIKYMALMLSLADIEKARSIAERALRTINIREESEKLNIWMAYFNLENEYGNPPEEAVVKVFQRALQYCDPKKVHLALLGMYERTEQHKLADELLEKMTKKFKHSCKVWLRRVQNVLKQHQDGVQPVINRALLCLPRHKHIKFISQTAILEFKSGVPDRGRSMFEGMLREYPKRTDLWSVYLDQEIRLGDIDIIRALFERAINLSLEPRKMKFLFKKYLEYEKSQGDEERIESVKRKAMEYANSTLA
The following text describes a protein:
Function:
Binds to lipopolysaccharides (LPS) present on the cell walls of Gram-negative bacteria, behaving as a pattern recognition receptor (PRR). Induces bacterial aggregation and enhances their subsequent clearance by the innate immune response. Binds to the inner core oligosaccharides region of rough-type bacterial LPS. Displays activity against the Gram-negative bacterium E.coli. Does not display any activity against the Gram-positive bacterium S.aureus or the fungi C.albicans.
Miscellaneous:
MISCELLANEOUS: In mouse bone marrow-derived mast cells (BMMC), inhibits LPS-induced expression of the inflammatory cytokine Interleukin-6 (IL-6).
Subcellular Localization:
Secreted. Note=Detected in larval plasma.
Sequence:
MDFKIFLFLTAIFMIVGVTVSTATTNPTAPRAYRPRINTTAGVCELEVPIVNILPPELKHTAHTIRGNGSAPGFSKIKICCSGYKIVAHTPFHCTPDCPSGCGLGNCTAPNVCTCNKGAGFGPDGKCISVCPGRCLNGQCYGNFCNCNSGFVLEPNGRYCTGGCTRNCGPGGQCVGNNQCSCLSGFALNSQGTCQMICAPGFQQMGSACEPLCPKGCVNGECVAPGQCRCKSGYALNSSKVCAPKCSQPCYNGFCSAPNVCTCKEGYIKDATSRNGNRCIAYCAAGCPNGTCSAPNFCICKQGYIKQSKGSNVCVKQ
The following text describes a protein:
Function:
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane (By similarity).
Domain:
Both the N-terminal core domain and the C-terminal headpiece domain are sufficient for binding to F-actin and necessary for actin bundling activity.
Sequence:
MERLQKQPLTSPGSVSSSRDSSVPGSPSSIVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRERSLSPKSTSPPPSPEVWAESRSPGTISQASAPRTAGTPRTSLPHFHHPETTRPDSNIYKKPPIYKQRAESTGGSPQSKHPIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASRRGAEEEEEEEDDDSGEEMKALRERQREELSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHAGTSKSSSLPAYGRTTLSRLQSTDFSPSGSEAESPGLQNGEGQRGRMDRGNSLPCVLEQKIYPYEMLVVTNRGRTKLPPGVDRMRLERHLSAEDFSRVFSMSPEEFGKLALWKRNELKKKASLF
The following text describes a protein:
Function:
Ribonuclease. Angiogenic. Plays a role in host defense. Exhibits strong antibacterial activity against Gram-negative bacteria but mild antibacterial activity against Gram-positive bacteria. The RNase activity is not required for the bactericidal activity.
Miscellaneous:
MISCELLANEOUS: Although the OmpT protease is absent in Gram-positive bacteria, LF-ZF3 generated by a Gram-negative bacterium can penetrate a Gram-positive bacterium and exert its cytotoxicity.
Subcellular Localization:
Secreted.
Sequence:
MGIHQCTAVVLLLLCASLSTYGQPAEIRRRYEHFLTQHVYGGITEQTCDRVMRQRRITRFPTGNDCKEVNTFIQANGNHVRTVCTGGGTRQTDNRDLYMSNNQFTVITCTLRSGERHPNCRYRGKESSRKIVVACEGEWPTHYEKGVIV
The following text describes a protein:
Function:
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing.
Subcellular Localization:
Nucleus.
Sequence:
MFPSSAENSGKCCSQPLFGSFASSESFETSGSDRYGAYESIGLGTLITEDSDSVFDNSNGGYSDTCSSTWAADMLGLDRPFAMSSQRSRSPFSDSGRESQHSTSNLSDSSSLHSPSHSRPAPIGSRGRDMHPYGQRNYRGRGAVVHEAKGQSVGCSCENPSIWIERYCSASPTLVFRGTKRKMMEPVPPCTLVKKKRIVRAAPSKSNIVGPHILEDSCLSSDAKEINGEHELGKKVRAREKRRRRREKNHEKYGDKHRLAFTCAFCKFHTFEDKDIEKHFGSTYHRETLDYIRRQAKFDDKVISFLHDCMVNKFHKTVSNLHKLKFSCGRSKDEWAKIMEGVTEDDYMRRMEVVYCVACDVHIPVLFSSVQQHLHSLTHLKSKVAYKEQLKRDSVVTAKAIINNDNVKERYEKYMKGEDPFATDAKDTSSDSQDANRSDEAEEDEEENSDS
The following text describes a protein:
Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYESVEVGGPTPNPFLVVEFYNQNRACLLPEKGLPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVKPSLPSASWANTLRYEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAAVAPASAPAPTEAARPPTPRDRPRHMDTALALRPGFSLPFYRPCDPAAALPRPVLPGSTGDLPWGTGREEAATPWTEAWALSGLPAPTAWADVRGRGRELSEAPGPLSQDGSWGPRVHQDTPLPSSPHLHHQQTPGLGSPILRTHKPLLPSWGTSTSPLPRLVTEGVGQGRGVPPVHTLPYQPQVLILAGFVFILIFLF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MNYSFTEKKRIRKSFAKRENVLEVPFLLATQIDSYAKFLQLENAFDKRTDDGLQAAFNSIFPIVSHNGYARLEFVYYTLGEPLFDIPECQLRGITYAAPLRARIRLVILDKEASKPTVKEVRENEVYMGEIPLMTPSGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDLLYFRIDRRRKMPVTILLKALGYNNEQILDIFYDKETFYLSSNGVQTDLVAGRLKGETAKVDILDKEGNVLVAKGKRITAKNIRDITNAGLTRLDVEQESLLGKALAADLIDSETGEVLASANDEITEELLAKFDINGVKEITTLYINELDQGAYISNTLRTDETAGRQAARVAIYRMMRPGEPPTEEAVEQLFNRLFFSEDSYDLSRVGRMKFNTRTYEQKLSEAQQNSWYGRLLNETFAGAADKGGYVLSVEDIVASIATLVELRNGHGEVDDIDHLGNRRVRSVGELTENQFRSGLARVERAVKERLNQAESENLMPHDLINAKPVSAAIKEFFGSSQLSQFMDQTNPLSEVTHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYARTNDYGFLETPYRRVIDGKVTEEIDYLSAIEEGRYVIAQANADLDSDGNLIGDLVTCREKGETIMATPDRVQYMDVATGQVVSVAASLIPFLEHDDANRALMGANMQRQAVPCLRPEKPMVGTGIERSVAVDSATAIVARRGGVVEYVDANRVVIRVHDDEATAGEVGVDIYNLVKFTRSNQSTNINQRPAVKAGDVLQRGDLVADGASTDLGELALGQNMTIAFMPWNGYNYEDSILISEKVAADDRYTSIHIEELNVVARDTKLGAEDITRDIPNLSERMQNRLDESGIVYIGAEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRMPTGMSGTVIDVQVFTREGIQRDKRAQSIIDSELKRYRLDLNDQLRIFDNDAFDRIERMIVGQKANGGPMKLTKGSEITTEYLAGLPSRHDWFDIRLTDEDLAKQLELIKLSLQQKREEADELYEIKKKKLTQGDELQPGVQKMVKVFIAIKRRLQAGDKMAGRHGNKGVVSRILPVEDMPYMADGRPVDIVLNPLGVPSRMNIGQILEVHLGWAAKGIGERIDRMLKERRKAGELREFLNKLYNGSGKKEDLDSLTDEEIIELASNLRKGASFASPVFDGAKESEIREMLNLAYPSEDPEVEKLGFNDSKTQITLYDGRSGEAFDRKVTVGVMHYLKLHHLVDEKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYENIVKGEHKIDAGMPESFNVLVKEIRSLGLDIDLERY
The following text describes a protein:
Function:
May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions. Binds to AT rich DNA.
Subcellular Localization:
Nucleus.
Sequence:
MGFPRIISKNNKIYTKLGAFCLSGDGQQFWIVCHTCQEELQTQDKFWKHIQDEHNFMHGPKQEQGRTAAQAYMEAAEAAAMTPLPLYRKVSENDQQRDDVVSTEDEDMQKEPKDYTEMRAHDDQQQTAAVAIDIKLEPSSLSQQSAVQAQQQQQQQQQQQQQQQQQQQQQEQLQQQQQQQQTQQIEITTPLMYQIPQVHPPVSAYAALVQAPAINTLNMSVAAAAAAVASNQVPSTMANLLPQELQYKQELQYKQEVQQHKESTNNSTTASASSAMSSDDGERFYICDFENCGLKFKYHSRLELHRSVHSKVRRFACEICGASFKQSCNLSTHRKKKHALKGTTKATLVPSQSF
The following text describes a protein:
Function:
Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
Subcellular Localization:
Cytoplasm.
Domain:
The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.
Sequence:
MRNYDLSPLLRQWIGFDKLASTMQGGQEPQGFPPYNIEKTDDNHYRISLALAGFKQSELDIEVEGPRLTVRGKPTPVEKQVEYLHQGLVRKEFSLTFTLAEHLNVDNAQFENGLLHIDLLRQVPEALQPQRIAIGSATPQERQVLESPEAPDQQ
The following text describes a protein:
Function:
Thought to form a receptor-activated calcium permeant cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVILSLYLAAFTLRLLLAGLAHKHCRDAPDGAACHYFTSAERSEWRTEDPQFLAEVLFAVTSMLSFTRLASILPAHESLGTLQISMGRMIDDMIRFMFILMIILTAFLCGLNNIYVPYQETERLGNFNETFQFLFWTMFGMEEHSVVDMPQFLVPEFVGRALYGIFTIVMVIVLLNMLIAMITNSFQKIEDAADVEWKFARSKLYLSYFREGLTLPVPFNILPSPKAIFYLLRRVFRFICCCHFCCKTKKPDYPPIPTFANPGAGAGPGEGERGSYRLRVIKALVQRYIETAQREFEETRRKDLGNRLTELTKTVSRLQSEVAGVQRAVVEAGPRRPPGGASVLSRYITRVRNSFQNLGPPIPETPELTVPATVGTQESSEIGLPDAGGAQAPASGESGPSSPAHVLVHREQESEGAGDLPQEADLGAKEGT
The following text describes a protein:
Function:
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.
Subcellular Localization:
Nucleus.
Sequence:
MAAAVPQRAWTVEQLRSEQLPKKDIIKFLQDHGSDSFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFESKRFKGTETISKVSEQVKNVKLNDDKQKDSKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLPDGTVFDTNIQTSSKKKKNAKPLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNTKLIFEVELVDID
The following text describes a protein:
Function:
Involved in early stages of melanosome biogenesis and maturation.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytosol.
Sequence:
MVRLYNLHPFGSQQVVPCQWEPEQVCCGGSDALFVAAGCKVEAFAVQGEELCRQRCAFSTLGRVLRMAYSEAGDYLVAIEEKNKTIFLRAYVNWRSKRSDNSRVCIRMVGHNVEASFCESFRDQMSIIEMPMSEAPLCFSCCPVKGDLLVGCTNKLVLFTLKYDIINEEFSILNFERSLIIHIDNITPVEISFCVGYVAVMSDLEVLLLKLESDPIHGESVDHHPQETSNPLKEAEGVSNETSQLESEDFVICLKPMELIGEKCEQSGISVKLESTGLEDEKVKYLRVRHLLYRRFAPDISSYVLSDNIKLHSLQLLPIHQSGFHPDENDLSPKKEMPNLFCFFSLPHVGYLYMVVKSVELMSVYWYPEKSQQAVLTPQFLHVITSQSLQCFTVRCSAAVAHEEDLYMDTTLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAEPEAIPERRESPKKLISRKDASVRSGTPHVAEAAWNLYLVNTTAPVQLYKEMVDYSNSYKTVKTESCLHLLSEAHLLVRAALMDGSQLEPAEKAELLEAFKESCGHLGDCYSRLTTEQSHLALPYYKMSGLSLAEVLARVDWTEESESQKYERGLVFYINHSLYENLDEELSKELAAKVAQIFHMAEPKQLPHVLSSPSMKNIDPLTALHYLRKLDSCGVSPVLVTLTKAAVALKMGDLDMYRNEMKSHSEMKLVYGFILEPRLLIQQWKGQIVPTELAIDLKETQPGLLVASVLGLQKNDKIGIVETDSFFKVLCGKDEDAVPQLLIDFWEAQLVACLPNVVLEELFFKLISQYVWRLSERRCPDTVPLRTAEDLINACSHYGLVNPWVHVLTTSDSLADKNYTDDLLKLQSLICSPSLDVASIIPFLEPLSEDTVAGLSTHALCHTRLQEYEQCIDTLLERCPEAVIAYANQELKEDHWILWWKKLLPELCQRVKSGGERSHLHLSLLKETLSVIAVGLDLRDFLNVLPEDGAAAFFLPYLLFCSRKKSLT
The following text describes a protein:
Function:
Component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTTPDAFRDAEYIADVSGISYGNVANLTEQDANVVPRENERMRKLQLAAKVAFIDRLLRDLDILIYCELSALYYMDCSVILFAIRAIVQLIFFTPKAPPFDPTRNQPFIGAIFVSNIFCMIFHNFFTHPEASEATRGYLHGGLLIDFIGQKAPISLFRLFLLDFLVLILDLVMLGLIVERVKTTGQTSTTSTEILRVQDHDSEERGVHRTRPESRSSVVGAELDETDGHITRANAGVGEQAEHTQLLADPSEDGHTPGAKNSHPLDAFSSGEAVIMNLGLFDVIRDQWKYSTTAPPARTSSYIPSDQTAAFLRARFGLQVGPDGRVQRIES
The following text describes a protein:
Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Sequence:
MSRDITKIRNVAIVAHAGAGNTKLAEQILFKTGQIDRVTTGETTGKVIDYEPEELARNMTLSCKVAYCDYKEHRINIIDTPGFVNFLEDTKNALRVSDGAVVIVSALSGVKAETERIWKYCDDYDLPRVVFVNKLDKENASFDRAVAEIEKVFGQEAIPLTLPIGEGPGLRGIVDLISLKAYEQDGKSVKEVPIPSELSSKVEEYRKKFVEKIAELDDSLLEKYLEGGELTEEELRKGLHDASIARRFIPVLAGSALLGIGVDALLDSIILALPDPQERANIYPIKGINPKDGSEAKREPSETAPLAAYVFKTTIDPFAGKISYIRVFSGVLKADSTVLNPNTGTKERIGQIYYILGKTQNPCQKAGHGEIVATVKLKDTLTGHTLCDENNPILLPEVRFSEPIISYAIAPKTRGDEEKVSAGLHKLLEEDPTLKFSRDEESKDMILSGMGQVHIEVALEKLKRKFGVEVNLMAPKVPYRETIRASASAQGKYKKQSGGRGQYGDCWIQIEPLPRGGGYEFVDKIVGGVIPQQYRPAVEKGIIETMKEGILAYYPIIDIKVTLYDGSYHPVDSSEMAFKIAGALALKKAFMDAKPVLLEPIMKAEIIVPDETLGTIIGDLNSRRGKVQGVDPQAGGNQKITALVPMAEMLTYANQLHSMTSGRGIYSMEFSHYEEVPSHIAQKIIEQRQKERQAKAEE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity to ensure proper cell division.
Subcellular Localization:
Chromosome, centromere.
Sequence:
MSAYEYPRLSRSDIITALKDAQIASVTETDLKTPTSDFVSELYTRILIYLDALDEEEKGQVDFEALEQLENPDHHATSMQAMKLYCKVKDMLEMLDCPLPISFKDLLRPESSRTEFFISALLNYGLYKDSKMDLIRPKAEELGLLDEQRKQCEAKVAQLNAEIGEFDEAVERDLPFVQELEANIEQLNKKILELNNQQMSLRATFQKMREKSTQMDNEISKAEFDLVETVQENANLRSQIVQSPDKLQGALEEKKLVLGETKKAEQSAMVTFQEKAAILEVFEKALKKILKSSSQLQLINEQVTNAKTVEKEFKALKDKLSEDGVAYKSLEAKVVERERIVEQLNESLKQLEKEKAVMFDDWTKQLNELKVEVESRRRELETRQTNVESVVAMVDDNTAKTNQVRQSGEAKVKKLAAKYEEIVKQFHEYTVSFDAFLPSL