lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a specific terminal uridylyltransferase for U6 snRNA. Responsible for the addition of UTP at the 3' end of U6 snRNA which stabilizes U6 snRNA. Does not have activity towards modified uridine containing 3'-monophosphorylation or 2'-O-methylation.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSSNLQLVETFDSRQFVVARWNRNDTTAMVPSAIAVVVFVESVEYKLGCKEKIGYSPTPEDQDQFMILQMESIDEANRICHDSIAKGFAINNTKIVFTPLLGLNGFRLQDAIDFMKTSQPHFNNDELLEVLTMAICQELPERLKILEDGFSFIEQGVSELIQNSACEMFGSFASPVRRNGYSDIDINVESVSAPGQRVSTNVRPLNEVVANPKCLITHPLTKSELETYPQEEIIKILYRCFNENSAFKTKFEMRFLPARTPIIVFKNIEVEGMNVSYDLSVHNQISVEKASLLHEFIVKDKSKGSRMKNAMMFIVHWAKSNKLLSGDYPEEKLEVKTKLNSYIINQLVIHFVQAATNKVHVNPQAKRDSRVNEYNFDTLFGDYCKFFRELFKYYANFDFTNKAIYGKKAMQKKTLSSAHGGVEESPLMLMDPMDITHNISAKVTEDAVKLLNGLIRNALFILKQNHFHINYLLETNTMATMLMKSREPKISISTRVTDGAEHQYLSVQLPAVVITSSDLFLLLTRVLRFNVCPNEQGPSVVDLCTPTGAIFLVTSRAWVGRRNTKRALKNSRHDLTPLQIDVMCSDKYDYEEDIAELRISMSTVPGTRIRLACIDIMRGQVSEVRDAIHFLIDQFINNNYDDLEKNGVQTISRIPIAAPTWP
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mL61 is not essential in cells grown at 30 degrees Celsius but is required for mitochondrial translation in cells grown at 18 degrees Celsius.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MSKVAQQLKFLNKISATTRLPQILVDPKKYSGLRLTFQTKNHNGHMGARVFWHNYLPTLQFYNPRMKFDVIRIKNEDKQKSVPCKLEILSHEGSVVETIDMRNKMHEDIMKDLLDKIEHVPLPENEIIRVGPQESII
The following text describes a protein:
Function:
Involved in allosteric regulation of aspartate carbamoyltransferase.
Sequence:
MKEELVVRRISDGTVIDHIPAGRALRVLKLLGITGERDGVVALVMNVPSKKLGKKDIVKIEGRELSKEEVDKISLIAPSATINIIRNFEVASKRRVELPRRVVGILRCLNPNCVTNAPREAVEPSFTLISESPLRMVCEYCGEYLREEDIIEQLSGV
The following text describes a protein:
Function:
Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Subcellular Localization:
Secreted.
Sequence:
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
Sequence:
MEASVSVEKSLSRWEAAPQVGPNTEGCRPACSCLAQLNLPPSCAGEPREPPQRGLIPFELCAAWRGTAPPPPHHLCGFTWERPAFVWSSLTVTWHFAWRPALNLAALDCADEANTAVCRDFNIPGFPTVRFFKAFSKSGSGATLSVAGADVQALRERLIDALESHSDTWPTACPPLEPARLKEINGFFARNNEEYLALIFEKEGSYLGREVTLDLSQHRGITVRRVLNTEGDVVSKFGVTDFPSCYLLFRNGSVSRVPVLVESRSFYTAYLQKFSGATRVAAQTSVAPTTAHTIAPTVWKVADRSKIYMADLESALHYILRVEVGKFSMLEGHRLVALRKFMAVLAQYFPGQPLTQNFLHSMNDWLKRQQKKKIPYNLFKNALDNRKEGAMIAKKVNWVGCQGSEPHFRGFPCSLWILFHFLTVQAARQNVDRSQETAKAQEVLQAIRSYVRFFFGCRECAGHFERMAAASMNRVKNPNSAVLWFWSSHNKVNARLAGAPSEDPQFPKVQWPPRELCSACHNELRGAPVWDLGNTLSFLKTHFSPSNIVLDLPSAVPGPRRGARRMAATPKPGELELADRNFTLGPEKAEIMVGPGTKSPGTLIPDVPVERLGESRPQEMHTGLGVTTAGPDQGPPERTAELQRDKLKQPKGQQHLTKRDTGAELLAEFLAEKPLPRGPSELRRVGRSSKQLASVPEGEPEAGAVRGRGQWLQVLERDFSHLDISLCVVLYSLSFMGLLAVYTYFRARMRALKGHASHLAA
The following text describes a protein:
Function:
Interacts specifically with the 8-bp sequence 5'-CACGTGGC-3'in the abscisic acid response element (ABARE). Also binds to the hexamer motif 5'-ACGTCA-3' of histone gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MASSSSATSGDDRPPAAGGGTPAQAHAEWAASMHAYYAAAASAAGHPYAAWPLPPQAQQHGLVAAGAGAAYGAGAVPHVPPPPAGTRHAHASMAAGVPYMAGESASAAGKGKRVGKTQRVPSGEINSSSGSGDAGSQGSSEKGDAGANQKGSSSSAKRRKSGAAKTEGEPSQAATVQNAVTEPPLEDKERSASKLLVLAPGRAALTSAAPNLNIGMDPLSASPSSLVQGEVNAAASSQSNASLSQMDERELKRERRKQSNRESARRSRLRKQQECEELAQKVSELTAANGTLRSELDQLKKDCKTMETENKKLMGKILSHDDKMQQSEGPSVVTTLSIQVEAPEPHQGGHGKAS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPKTTKKIAILTSGGDAPGMNATLVYLTRYATSSEIEVFFVKNGYYGLYHDELVPAHQLDLSNSLFSAGTVIGSKRFVEFKELKVREQAAQNLKKRQIDYLVVIGGDGSYMGAKLLSELGVNCYCLPGTIDNDINSSEFTIGFLTALESIKVNVQAVYHTTKSHERVAIVEVMGRHCGDLAIFGALATNADFVVTPSNKMDLKQLESAVKKILQHQNHCVVIVSENIYGFDGYPSLTAIKQHFDANNMKCNLVSLGHTQRGFAPTSLELVQISLMAQHTINLIGQNKVNQVIGNKANVPVNYDFDQAFNMPPVDRSALIAVINKNII
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MNQSVRYFLEGNEIDIPTEDPPSDAQDTKNPIDLKGKFKNFNSYKMYQAAGDVSYPESNEDRYLHLRQYYINQVKGEKQRAENETMSGAFKRIINDEPLEKIEGYYTLRQRWRQEMHEQIKDGKKICHCQNCINVALPGSDYCINHILEDKNQKLFIACPKCHRPHPFFSVCFTCGV
The following text describes a protein:
Function:
Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress. Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity. Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids. Also present at mitochondria-endoplasmic reticulum contact sites; where it interacts with EIF2AK3/PERK.
Domain:
The transmembrane domain and a C-terminal adjacent region contain all information necessary for mitochondrial targeting.
Sequence:
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MKATKVLLTLGGITYTGAARAASFVDVSKLTHHHTSALQRHHRHNQQRLTHHPRQPSPIISLQAKRNNSGNKRKKEQSLDSLLALETDLHSRGYQFVIGSDDSGGAGCIAGPVVVASCCLLQPFSAVLPLDVSTKQSTAADKLLSQSEMEIMAIVNDSKTLTPQQRIDVYNVICAHPDVFAVSVAQRSPQEIDDINLTRATQLAFAESIESLVENYNLPFDKIYAIVDGKVSPKLYALQSSDTESSMQQQQSTQQSQQAAPKRFSVRPYTNGDANVFTVALSSIVARVSRDAIIAELHDQYPSYGFDENLGYGSREHVEAVHRLGALTGVHRLSFKQVKGR
The following text describes a protein:
Function:
May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. Has a role in rRNA biogenesis together with PWP1 (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1.
Sequence:
MAEMKSPTKAEPATPAEAAQSDRHSLLEHSREFLDFFWDIAKPDQETRLRATEKLLEYLRTRPNDSEMKYALKRLITGLGVGREAARPCYSLALAQLLQSFEDIPLCDILDQIQEKYSLQAMNKAMMRPSLFANLFGVLALFQSGRLVKDKEALMKSVQLLKILSQHPNHLQGQPIKALVDILSEVPESMFQEILPKVLKGNMKVILRSPKYLELFLLAKQRVPTKLESLMGSVDLFSEDNIPSLVNILKVAANSVKKEHKLPNVALDLLRLALKESRFELFWKKVLEEGLLKNPSWTSSYMCFRLLGASLPLLSEEQLQLVMRGDLIRHFGENMVISKPQNLFKIIPEISTYVGTFLEGCQDDPKRQLTMMVAFTTITNQGLPVMPTFWRVTRFLNAEALQSYVAWLRDMFLQPDLNSLVDFSTANQKRAQDASLNVPERAVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIARFCLFHAFFKTKKATPQIPETKQHFSFPLDDRNRGVFVSAFFSLLQTLSVKFRQTPDLAENGKPWTYRLVQLADMLLNHNRNVTSVTSLTTQQRQAWDQMMSTLKELEARSSETRAIAFQHLLLLVGLHIFKSPAESCDVLGDIQTCIKKSMEQNPRRSRSRAKASQEPVWVEVMVEILLSLLAQPSNLMRQVVRSVFGHICPHLTPRCLQLILAVLSPVTNEDEDDNVVVTDDADEKQLQHGEDEDSDNEDNKNSESDMDSEDGEESEEEDRDKDVDPGFRQQLMEVLKAGNALGGVDNEEEEELGDEAMMALDQNLASLFKEQKMRIQARNEEKNKLQKEKKLRRDFQIRALDLIEVLVTKQPEHPLILELLEPLLNVIQHSMRSKGSTKQEQDLLHKTARIFMHHLCRARRYCHEVGPCAEALHAQVERLVQQAGSQADASVALYYFNASLYLLRVLKGNTNKRHQDGHKLHGADTEDSEDQAANCLDLDFVTRVYSASLESLLTKRNSSLTVPMFLSLFSRYPVICKNLLPVLAQHVAGPSRPRHQAQACLMLQKTLSARELRVCFEDPEWEQLITQLLGKATQTLQTLGEAQSKGEHQKELSILELLNTLLRTVNHEKLSVDLTAPLGVLQSKQQKLQQSLQQGNHSSGSNRLYDLYWQAMRMLGVQRPKSEKKNAKDIPSDTQSPVSTKRKKKGFLPETKKRKKLKSEGTTPEKNAASQQDAVTEGAMPAATGKDQPPSTGKKKRKRVKASTPSQVNGITGAKSPAPSNPTLSPSTPAKTPKLQKKKEKLSQVNGATPVSPIEPESKKHHQEALSTKEVIRKSPHPQSALPKKRARLSLVSRSPSLLQSGVKKRRVASRRVQTP
The following text describes a protein:
Function:
Receptor for the A2 pheromone, a prenylated mating factor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLDHITPFFALVAFFLVLMPFAWHIKSKNVGLIMLSIWLMLGNLDNFVNSMVWWKTTADLAPAYCELSVRLRHLLFIAIPASNLAIARKLESIASTRQVRAGPGDHRRAVIIDLLICLGIPIIYTSLMIVNQSNRYGILEEAGCWPMMVFSWLWVLLVAAPVIVVSLCSAVYSALAFRWFWVRRRQFQAVLASSASTINRSHYVRLLLLTAIDMLLFFPIYVGTIAAQIKSSISIPYGSWSSVHTGFNQIPQYPASLVLMENTFQRNLILARLVCPLSAYIFFAMFGLGLEVRQGYKEAFHRALLFCRLRKEPKASALQHVVADIEVVTFRSHDTFDANTSTKSEKSDIDMRGSEAA
The following text describes a protein:
Function:
Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein; Lumenal side.
Sequence:
MAVEMCFLGKGFRCLVLFLFILQLFTPIFSIKRKLNLQEYLCPPKIQECKDKNISLVYVSAESADHDNVVHFVWSGFQGPSIINAYSEKLPEKHAKPGLNVKWENLFKNDTEGALEFTPKVDYITAFSLSSVLQFADPKDEIYFTKTGGVIEHNLRSVQWRKVILDKDNDNATFVGEFLGGTISFSCAAADHDDRDEEPPRPRYSSNSTRFTVNLSHLKTNSTDRLALEFVSVVKSEESMPSCSREFQSIDDEHSPGIFRTVVINNTYATYSSFISWKPVMYTKLDRGLKTQLPAFNYLYKNGKFEQTKISSKHCFHLTERKTLLPKIILGAMSKDIITYPIRLSSGQKKDGWYKATQLLSWSGQAGCGQPLFDSISKTLYITIIAGLGIPALIILGGFYCLAADLRKSLRATCKCKLVKVQRDV
The following text describes a protein:
Function:
Mitochondrial DNA endonuclease involved in intron homing.
Miscellaneous:
MISCELLANEOUS: Endonuclease aI5 beta (group I intron) is encoded within an intron of the mitochondrial COX1 gene. Splicing from COX1 requires PET54, MRS1, SUV3 and MSS18. Translational initiation codon is predicted to be ATA rather than ATG.
Subcellular Localization:
Mitochondrion.
Sequence:
MLMLLMMILTNNKVFMETLYYYLMFNFQLMSPFGVPVPGPAPETKDIKNLYESIMNNYINILNKYTININKDNINKLKFLDNYTEEEKGYYLSGLFEGDGNIYTRCFSITFSLEDVLLANYLCTYFKIGHITAKYNFNKELTAVKWNIMKKKEQEVFMNYINGKLLTYKRYDQYFKYNFNNRLNIKLLKPKEFDLTLNPWLTGFNDADGYFYTGFQKHKNSQWLKFHLELSQKDSYILDIIKKYFKTGGILKRDYKSGATAYIYKAQSSKAMKPFIEYFNNYQPLSTRRYKQYLLLNIAYLLKLNKLHMLTNSLLMLKELMLLQSVKNMSLEMKNELNNRVKIIINKTHYNNIE
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm. Contractile vacuole.
Sequence:
MASLIGSAKLPFNNEVELISDEIEKGLNDSTTIRKFFEKRAQIEEEYAKNLQKLCKATPILLKSGGTSDAFSMIVESTNQFSNHTISTIQRFNQDVNDPLAGFIKDLRGELKQYSLEGQNLAKERKQAFDSLKSSKALYEQMCNNPESDVMKVQQSEEEYKLQVQACNQYHSLYHQEKLPKIQNEIIRLETVRMQKMKTNLKKYITEFESIPQKQQQSIKDSEELINSIDTKQDIQSFTNFNKTLNTPTPDFQFESCESINGGGGGAAGRKSKKGGWRQTISVLKIGNAFMKDDGTIVNGNSSLNSSSSNINILNNPIVFKIPIEEIMFKQKSKFPNLDIPYILVLLVNLIKKLDNGMGMKTEGIFRIPGHTSEVNALKKLINEQGEYQFPPDLYSIHPIASLLKLWLREMPQPLIPNYVYDKSLECQSIEEFIVFFKFLPASNQKIITYLAGFLNELVQPDNVVTSKMNLDNVAMVFAPSFLRCDSQDMILANVDREKTLVKLIIEGYLKLSDVCPIQLDDIDSKIQIPSFSNNNNNSTTTTTTTTTTTVPSSTSTNITTNGASALGAESSTTPLPSLTTFSQSQSSSPPNQPSPSITPQQVSNLPPSYQPPQPPPTMAPPPLFNIPQQQQQQQVTNNNNSGGYTPPPLQYTQSSSNLPPIQLGVTNSPSKPQLSDKQKEKEKEKEKEKEKEKEREKEKEKEKEKEKEKEKEKEKKGHKKSSSSTSPNSSSLSISNFLSSNKDKDKEKDKEKEKEKEKEKDKEILATNSTPEKPVSNRMSLIFSQQLQQQLQQQIQQHQQLQQQSNGSPTSPISPSSANNSPSMSPSMVKRTIRPNLPPLQSGTSATTSSSSLTSSSSPTLTSSKDNIQKQQLPELNQQQQQQSPQAELKSSGIKSLLQRVPPPPSQS
The following text describes a protein:
Function:
Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, axon.
Sequence:
MRPLRCGERTQGIPLGLLAFWVTAARCLQSQGVSLYIPQSAINATVQQDILLSVDYICHGVPTIEWKYTPNWGVQRIVEWKPGTPANVSQSHRDRVCTFDNGSIQLFNVSVKDSGYYIVTVTEHPGSSQSGTILLRVSEIRYEDLHFVAVFFALLAAVAVVLISLMWVCNQCAYKFQRKRRYKLKESTTEEIEMKEVEC
The following text describes a protein:
Function:
The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
Subcellular Localization:
Virion.
Sequence:
MDSSRTIGLYFDSTLPSSNLLAFPIVLQDTGDGKKQIAPQYRIQRLDSWTDSKEDSVFITTYGFIFQVGNEEATVGMINDNPKRELLSTAMLCLGSVPNVGDLVELARACLTMVVTCKKSATNTERMVFSVVQAPQVLQSCRVVANKYSSVNAVKHVKAPEKIPGSGTLEYKVNFVSLTVVPRKDVYKIPTAALKVSGSSLYNLALNVTIDVEVDPKSPLVKSLSKSDSGYYANLFLHIGLMSTVDKKGKKVTFDKLERKIRRLDLSVGLSDVLGPSVLVKARGARTKLLAPFFSSSGTACYPIANASPQVAKILWSQTACLRSVKVIIQAGTQRAVAVTADHEVTSTKLEKGHTIAKYNPFKK
The following text describes a protein:
Function:
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress.
Miscellaneous:
MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAVQTPRQRLANAKFNKNNEKYRKYGKKKEGKTEKTAPVISKTWLGILLFLLVGGGVLQLISYIL
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MFSQALLRSTRQTIATSRACKPTTTNNNGLRKAFYSDDKSAGQQLSPATTERPSGIQPASSSDDPQLIPAGLTSGAPEQLAIRPVRIYRPSPTTMQSAKANNHTWVLDWETLQGAGRWENPLMGWASTADYMQGTNLKFDSSEAAVAFCEKQGWPYFVQAPKAIKFKVKSYSDNYLYSDSKLRIHKTK
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MHPVISDALRNAHGTYHAALDRYYALTTKQRIAVWLGLGFAGFMGLGFLIWHQTLIAWLVGFAEKVHDTPFAWVGLFLAICIISFPPLIGYSMISTFCGMAYGFPNGWPLLAAATIIGSTASFLIVSRRFANYARHLAQTNTKFAALTQTMEKDSFALLWMIRLCPLPYSLSNGALASIPSITPQAFALATAITSPKLLIHVFVGDRLARLGQGEKDWTSTLVDFLSIGIAVSAGAITAYIVYTRTLQRAAEIEAEQHPNLDELDVLDDDEFIVNDV
The following text describes a protein:
Function:
Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST
The following text describes a protein:
Function:
Involved in tetrahydrobiopterin biosynthesis (By similarity). Interacts with and acts downstream of the E3 ubiquitin-protein ligase SDIR1 in abscisic acid (ABA) and salt stress signaling. Regulates the expression of the bZIP transcription factor ABI5, which mediates responses to ABA during seed germination and salt stress. The SDIR1-ATP1/SDIRIP1 complex plays an important role in ABA signaling through the ubiquitination pathway. Acts downstream of AIRP2 in regulation of ABA signaling during drought stress.
Subcellular Localization:
Plastid, chloroplast. Cell membrane; Peripheral membrane protein. Nucleus.
Sequence:
MAATSSSPPCNISASSLLLRQPSRSILKVFGLLPPVSRNNRKLGRLTVTRSNLAQDFLGDFGARDPYPEEIASQFGDKVLGCQSTEHKILIPNASVLSLSQLQCSPVSSSQPPLSGDDARTLLHKVLGWSIVDNEAGGLKIRCMWKVRDFGCGVELINRIHKVAEASGHYPSLHLESPTQVRAELFTSSIGGLSMNDFIMAAKIDDIKTSDLSPRKRAWA
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MNGVQISPDESILWQSEAWPVVKINVTLAFTWLVMALLVIGSWWITRRLTSDTKIPRWQNLLEVLVTGIRDQIRDVSRHDPGPYMPFVGTLFLFIAVANLLSIVPGYVAPTGSLSTTAALATCVFVAVPVFGIASHGVGDYLKRYLQPTPLMLPFNLIGELSRTLALAVRLYGNMMSGAVIAAILISFVPLFVPIVMQVMGLLTGMIQAYIFAVLAMVYIASATKVAK
The following text describes a protein:
Function:
Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon.
Sequence:
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQGCNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVIMEEPPERDSTVAVIVGASVGGFLAVIILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK
The following text describes a protein:
Function:
Acetylates the N-terminal alanine of ribosomal protein bS18.
Subcellular Localization:
Cytoplasm.
Sequence:
MMEPTIHLRQAKAGDIPAILEIEQECFQEDSFSREQFVYLICRSKGTFYVVVEQERIIAYVSLLFHAGTRYLRIYSIAVHPDCRGRKLGQLLMERTIETALDCRAVKITLEVKESNTPAIKLYMKNGFIPVGVKPNYYHDGSDAIYMQRHM
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MTRAGGRSPLAPRRTLPATVVDDTVAAAAILLDKWHPDEDSFGSSLFLDSTPDEVDAFLRAAKDLHRAMLFYASGAATAADALHAGGHGLIHAQELLDTAMRRLQRELQLLLTSLPAVLHFRQDDDDDDEQEDDQSLVDACAHLRVVAEAMMAAGYGKECVSIFKARRRAAVTANLQRLHGFSLSPQHAQVHKFSWEQVDAKIQSWLAGARVAFTSVFSAERELCDRVFVGDNEGVGDAVFGAIADDHATNILAVAEAAVGRSRRAPERLFRVLDVHDALTETILPAIVSAFGEKSEVTSRAATLVTTKVSEAVRSMVASFEAAIEKEPSKGTVPGGAVHPLTRYVMNYLSFLADYENALAHIYFYQQGVGAGGDQFTDTSSLASGSMASSSDLSSSSSSSPALSVWSNPIGWLVHVLLRKLDAKAGSYREPALSYLFLANNTHYVAKKVGGGTKLERVLGEEWAEAQRAKARGYVDVYVRAAWGSKVLRGGAVEEAVVQMVAMQEKWVAADDEMGEALRAAAKEAVVPMYRLFYRRQGAVARLTPGDVITMIDGLFGGRNAGAGDENVAAGGRRRPSQQQQQQQEVPVEIRNGKTRRQRVTITD
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MPSVFVQGRPTASYPPFAPEAGRGAVRRVTEVGEEVLHRPCRDVTEFGPDLAALIDDMFRTMYVAEGAGLAANQVGVDLRLFVYDCPDDEGVRHVGHLVNPVLDALDPAARRLLDEGEGCLSVPGAVMAVPRPDRAVVRGLDKDGVPLLVEGTGYFARCLAHETDHVNGHVYLDRLSGRERKAALRQSADRREEVFARRAANAAAFAA