The following text describes a protein:
Function:
Transcription factor involved in maintaining normal fat levels. Regulates the expression of genes involved in lipid metabolism in response to nutrient availability, such as the fatty-acid desaturases fat-5, fat-6 and fat-7. In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation, acting in concert with transcription factor mxl-3. Plays a role in synthesis of monomethyl branched-chain fatty acids (mmBCFAs) as well as other very-long-chain fatty acids. Downstream of the cis-Golgi membrane protein eas-1/GOLT1B and the E3 ubiquitin ligase rnf-145/RNF145, plays a role in the regulation of glial size, perhaps by modulating synthesis of long-chain polyunsaturated fatty-acids (LC-PUFA). Modulates expression of genes in the one-carbon cycle, which produces the methyl donor S-adenosylmethionine (SAM). Probably involved in a feedback loop in which decreased levels of SAM lead to increased transcriptional activity of sbp-1, thereby causing lipid accumulation. Involved in the negative regulation of zinc homeostasis. Involved in the response to simulated microgravity, in concert with Mediator complex subunit mdt-15, probably acting in the intestine. Plays a role in transgenerational lipid accumulation in response to a high-fat diet, probably acting by upregulating wdr-5.1 expression to increase the level of trimethylated 'Lys-4' histone H3 (H3K4me3), which may then induce the expression of fat-5, fat-6 and fat-7. May act as an oxygen sensor for lipid metabolism; [Sterol regulatory element binding protein sbp-1]: Precursor of the transcription factor form, which is embedded in the endoplasmic reticulum membrane (By similarity). Processing of this form allows release of the transcription factor form that translocates into the nucleus and activates transcription of genes involved in sterol biosynthesis and lipid homeostasis (By similarity); [Processed sterol regulatory element binding protein sbp-1]: Key transcription factor that regulates expression of genes involved in sterol biosynthesis and lipid homeostasis.
Subcellular Localization:
Nucleus. Note=Localization to nucleus is enhanced in a sams-1-dependent manner. Localized to nucleus in an eas-1-dependent manner. Nuclear localization is reduced by lowering the level of zinc. Does not accumulate in the nucleus of AMsh glial cells during the early larval stages (L1 to L3), but has strong nuclear localization in adulthood; [Sterol regulatory element binding protein sbp-1]: Endoplasmic reticulum membrane; Multi-pass membrane protein; [Processed sterol regulatory element binding protein sbp-1]: Nucleus.
Sequence:
MNEEFEGDVPMSDPFLSLVTKLDDIAPFPNNDPLDFDMEHNWQEPGPSQQPDPSIPGNQHSPPQEYYDIDGQRDVSTLHSLLNHNNDDFFSMRFSPPNFDLGGGRGPSLAATQQLSGEGPASMLNPLQTSPPSGGYPPADAYRPLSLAQQLAAPAMTPHQAASLFVNTNGIDQKNFTHAMLSPPHHTSMTPQPYTEAMEHINGYMSPYDQAQGPSGPSYYSQHHQSPPPHHHHHHPMPKIHENPEQVASPSIEDAPETKPTHLVEPQSPKSPQNMKEELLRLLVNMSPSEVERLKNKKSGACSATNGPSRSKEKAAKIVIQETAEGDEDEDDEDSDSGETMSQGTTIIVRRPKTERRTAHNLIEKKYRCSINDRIQQLKVLLCGDEAKLSKSATLRRAIEHIEEVEHENQVLKHHVEQMRKTLQNNRLPYPEPIQYTEYSARSPVESSPSPPRNERKRSRMSTTTPMKNGTRDGSSKVTLFAMLLAVLIFNPIGLLAGSAIFSKAAAEAPIASPFEHGRVIDDPDGTSTRTLFWEGSIINMSYVWVFNILMIIYVVVKLLIHGDPVQDFMSVSWQTFVTTREKARAELNSGNLKDAQRKFCECLATLDRSLPSPGVDSVFSVGWECVRHLLNWLWIGRYIARRRRSTTKPVSVVCRSHAQTAVLYHEIHQLHLMGITGNFEDTYEPSALTGLFMSLCAVNLAEAAGASNDGLPRAVMAQIYISASIQCRLALPNLLAPFFSGYFLRRARRHVRRAPEHSVSHLLWIFHPATRKFMSDAKRLEHVLSSKQKQLRFGSFVEDEQLSPLARIRTTLKVYLLSKLVQELVGGDEIFTKNVERILNDNDRLDDEVDVVDVSRLLVTISTQCAAILTNEKDESAKFGTWISRNGDACCTWWTHVLTCGIYWRSNKNELARQHYSLIRNCPPKILTDNLGLAVGHALCARKICIDDRDSPKVSQYVCIHTKKSLESLRLFSTSSRASGVVSGIQEGTRRMAYEWIMNSLLDAWRSNLFASKPYWTQSFKGQSTFSTLYQEAYNHYAIINGTRGDCWRLFVYELTCRMLNGANPQATWSGVRRVRSTKMDAVRGRVSMRRSAQPDAFHLHTLVKLHTSMDL