lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localized to centromeres and spindle poles in endopolyploid tumor cells.
Sequence:
MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLRVNVVKTCEEILNYVLVRVQPPQPGLPRPRFSLYLSAQLQIGVIRVYSQQCQYLVEDIQHILERLHRAQLQIRIDMETELPSLLLPNHLAMMETLEDAPDPFFGMMSVDPRLPSPFDIPQIRHLLEAAIPERVEEIPPEVPTEPREPERIPVTVLPPEAITILEAEPIRMLEIEGERELPEVSRRELDLLIAEEEEAILLEIPRLPPPAPAEVEGIGEALGPEELRLTGWEPGALLMEVTPPEELRLPAPPSPERRPPVPPPPRRRRRRRLLFWDKETQISPEKFQEQLQTRAHCWECPMVQPPERTIRGPAELFRTPTLSGWLPPELLGLWTHCAQPPPKALRRELPEEAAAEEERRKIEVPSEIEVPREALEPSVPLMVSLEISLEAAEEEKSRISLIPPEERWAWPEVEAPEAPALPVVPELPEVPMEMPLVLPPELELLSLEAVHRAVALELQANREPDFSSLVSPLSPRRMAARVFYLLLVLSAQQILHVKQEKPYGRLLIQPGPRFH
The following text describes a protein:
Function:
Permease for nitrate uptake.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDFAKLLVASPEVNPNNRKALTIPVLNPFNTYGRVFFFSWFGFMLAFLSWYAFPPLLTVTIRDDLDMSQTQIANSNIIALLATLLVRLICGPLCDRFGPRLVFIGLLLVGSIPTAMAGLVTSPQGLIALRFFIGILGGTFVPCQVWCTGFFDKSIVGTANSLAAGLGNAGGGITYFVMPAIFDSLIRDQGLPAHKAWRVAYIVPFILIVAAALGMLFTCDDTPTGKWSERHIWMKEDTQTASKGNIVDLSSGAQSSRPSGPPSIIAYAIPDVEKKGTETPLEPQSQAIGQFDAFRANAVASPSRKEAFNVIFSLATMAVAVPYACSFGSELAINSILGDYYDKNFPYMGQTQTGKWAAMFGFLNIVCRPAGGFLADFLYRKTNTPWAKKLLLSFLGVVMGAFMIAMGFSDPKSEATMFGLTAGLAFFLESCNGAIFSLVPHVHPYANGIVSGMVGGFGNLGGIIFAIIFRYSHHDYARGIWILGVISMAVFISVSWVRPVPKSQMRE
The following text describes a protein:
Function:
ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/RAD3 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. XPD/RAD3 acts by forming a bridge between TFIIK and the core-TFIIH complex. Involved in the maintenance of the fidelity of DNA replication. Has single-stranded DNA-dependent ATPase activity. 5'-3' DNA helicase activity requires ATP (dATP partially substitutes), will unwind over 800 bp dsDNA. Able to unwind an RNA:DNA hybrid.
Miscellaneous:
MISCELLANEOUS: Present with 14400 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKFYIDDLPVLFPYPKIYPEQYNYMCDIKKTLDVGGNSILEMPSGTGKTVSLLSLTIAYQMHYPEHRKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFRGLGLTSRKNLCLHPEVSKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLYNIEVEDYLPKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQKLQDEYEKLVQGLHSADILTDQEEPFVETPVLPQDLLTEAIPGNIRRAEHFVSFLKRLIEYLKTRMKVLHVISETPKSFLQHLKQLTFIERKPLRFCSERLSLLVRTLEVTEVEDFTALKDIATFATLISTYEEGFLLIIEPYEIENAAVPNPIMRFTCLDASIAIKPVFERFSSVIITSGTISPLDMYPRMLNFKTVLQKSYAMTLAKKSFLPMIITKGSDQVAISSRFEIRNDPSIVRNYGSMLVEFAKITPDGMVVFFPSYLYMESIVSMWQTMGILDEVWKHKLILVETPDAQETSLALETYRKACSNGRGAILLSVARGKVSEGIDFDHQYGRTVLMIGIPFQYTESRILKARLEFMRENYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFSRKRSQLPKWIAQGLSDADLNLSTDMAISNTKQFLRTMAQPTDPKDQEGVSVWSYEDLIKHQNSRKDQGGFIENENKEGEQDEDEDEDIEMQ
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MREDLLRNSVEFLREKTVLDAPDVKKIEFLKSKGLTAEEIQEAFKLAKNPLFPSYPRFENTSNFVSRDWRDWFIMGVISTGFAWSAYSLVKKYIAPMFRAPSQNAYEADKNALDAKFLEAHKILENLDEQTRKLSERTEKQQDELDIALDDLEETLNTLKRTSENRDREIARISQDVYTMSTITLPQSLEQIKKSQEEALQNLSREISSLRCLQTDSKKDDTFATTSNSSIPVLENPLDTSEGFQTKKVGTASLPDWQISMHNEASKNIDFNDIDPAESYVAEDAY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGASGAGGPGGAARCPLCQEPFPDGLQLRKNHTLSELLQLRQGSGPGSGPGPAPALAPEPSAPSALPSVPEPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHRLVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQEHRGHELVPLEQERALQEAEQSKVLSAVEDRMDELGAGIAQSRRTVALIKSAAVAERERVSRLFADAAAALQGFQTQVLGFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVPEADSVSFLQELLALRLALEDGCGPGPGPPRELSFTKSSQAVRAVRDMLAVACVNQWEQLRGPGGNEDGPQKLDSEADAEPQDLESTNLLESEAPRDYFLKFAYIVDLDSDTADKFLQLFGTKGVKRVLCPINYPLSPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWVSMGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLEYADRALAFYAVRDGKMSLLRRLKASRPRRGGIPASPIDPFQSRLDSHFAGLFTHRLKPAFFLESVDAHLQIGPLKKSCISVLKRR
The following text describes a protein:
Function:
Plays an important role in the biosynthesis of the phospholipid phosphatidylcholine. Catalyzes the formation of CDP-choline.
Sequence:
MVAVRRGNPPGNSGHSLDMARRGKRKAPAAVDENLVDTGNEAILSNQRSNDEAEDREEFQDATDEESPEEDNGACRKLVASEADGCVGPASAVSPLADGQNPFHCDRPVRVYADGIYDLFHFGHARALEQAKKLFPNVYLLVGCCNDELTHKYKGKTVFTEEERYESLRHCKWVDEVVKDAPWVVTKDFIEKHDIDYVAHDALPYADASGSADDVYGWVKSVGKFAETKRTEGISTTDIIMKILKDYNQYIMRNLNRGYSRKEMGVSYVKEKQLRVNMGVAKLREKVKQQQQKVEKTVRERLEKNQEYFKKNVKEMTDNVGTVVEWVENADKWIAGFLGKFEEGVYNVEKIITYPLLRPRLTRQSSKKDSSAKPSPKDKAKTRSEDGPPPAKRMAV
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSKVTAHAIDFKERHKEPRNQVFVPMDGIREDAVGGRLTIPPPPLTVDGISQNMAQMMIYHDGSLRVFNSLTPEKVRQIMLIAATSDPISVPKILEKVPSFESSTAETPQASRPHDQAQHIGRLQSDFPLARRFSLQRFLEKRRVRLGNKTPYATPHGCAAVDPCSNSHHFSGETTESL
The following text describes a protein:
Function:
Lipid transfer protein that, together with LTPG2, binds to lipids and functions as a component of the cuticular lipid export machinery that performs extensive export of intracellular lipids (e.g. C29 alkane) from epidermal cells to the surface to build the cuticular wax layer and silique walls. Involved in the establishment of resistance to the necrotrophic fungal pathogen Alternaria brassicicola. Contributes to pre-invasive defense against some non-host powdery mildew pathogens by preventing the penetration of the epidermal cell wall by the fungal agents (e.g. Blumeria graminis f. sp. hordei (Bgh)). Maybe involved in seed and ovule maturation and development, probably by regulating the fatty acids homeostasis during suberin and sporopollenin biosynthesis or deposition (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Endoplasmic reticulum. Golgi apparatus. Note=Targeted to the plasma membrane via the vesicular trafficking system. Localized to the plasma membrane on all faces of epidermal cells. Also detected in the periclinal cell wall. In young meristematic cells, observed in plasma membrane and in puncta resembling the Golgi. Localized to papillae at the sites of Blumeria graminis f. sp. hordei (Bgh) penetration (Bgh).
Sequence:
MKGLHLHLVLVTMTIVASIAAAAPAAPGGALADECNQDFQKVTLCLDFATGKATIPSKKCCDAVEDIKERDPKCLCFVIQQAKTGGQALKDLGVQEDKLIQLPTSCQLHNASITNCPKLLGISPSSPDAAVFTNNATTTPVAPAGKSPATPATSTDKGGSASAKDGHAVVALAVALMAVSFVLTLPRHVTLGM
The following text describes a protein:
Function:
Serine endopeptidase which, by cleaving prophenoloxidase activating factor PPAF2, is required for the activation of the prophenoloxidase cascade probably following the recognition of pathogen-derived products.
Subcellular Localization:
Secreted. Note=Secreted in the hemolymph.
Domain:
The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Sequence:
MWLSLVILGVASAIVNVSTQESCTTPNGETATCLPIESCKIFWDYVVTSGADPEINSFLRASLCRQGNYVVCCGSTLKFNSALPDRTECGLQDDFKVLGGEDTDLGEYPWMALLQQTKTSGAKSFGCGGSLISDRYVLTAAHCVVSSSYTVTMVRLGEWDLRATQDCVGSGSYQYCSPPPQDIGIESITSHPNYEKSSRGVFNDIALIRLARPVNRNKYVQPICLPLPTERTPVGENLLVAGWGATETKAQSDKKQKLKLPVTDLPACKTLYAKHNKIINDKMICAGGLKGKDSCKGDSGGPLFGQTGAGNAQFYIEGIVSYGAICGTEGFPAIYTRVSDHLDWIKQNVRV
The following text describes a protein:
Function:
Plays a role in the inhibition of programmed cell death by converting the toxic proline catabolism intermediate (s)-1-pyrroline-5-carboxylate (P5C) to glutamate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MYRVFASRALRAKSLCDKSSTSLASLTLSRLNHSIPFATVDAEELSGAHPAEVQSFVQGKWIGSSNHNTLLDPLNGEPFIKVAEVDESGTQPFVDSLSQCPKHGLHNPFKSPERYLLYGDISTKAAHMLALPKVADFFARLIQRVAPKSYQQAAGEVFVTRKFLENFCGDQVRFLARSFAIPGNHLGQQSHGYRWPYGPVTIVTPFNFPLEIPLLQLMGALYMGNKPLLKVDSKVSIVMEQMMRLLHYCGLPAEDVDFINSDGKTMNKILLEANPRMTLFTGSSRVAEKLALDLKGRIRLEDAGFDWKVLGPDVQEVDYVAWQCDQDAYACSGQKCSAQSMLFVHENWSKTPLVSKLKELAERRKLEDLTIGPVLTFTTEAMLEHMENLLQIPGSKLLFGGKELKNHSIPSIYGALEPTAVYVPIEEILKDNKTYELVTKEIFGPFQIVTEYKKDQLPLVLEALERMHAHLTAAVVSNDPIFLQEVIGNSVNGTTYAGLRGRTTGAPQNHWFGPAGDPRGAGIGTPEAIKLVWSCHREVIYDYGPVPQGWELPPST
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasmic vesicle membrane. Presynapse. Note=Mainly cytoplasmic with partial expression at the plasma membrane (By similarity). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).
Domain:
The Rab-GAP TBC domain is essential for phosphatidylinositol binding.
Sequence:
MHPPAYNCFVDRDKMDSAIPDLGPKELSCTELQELKQLARQGYWARSYALRGQVYQRLIRDIPCRTVTPDASVYRDIVGKIVGKHSSASLPLPEFVDNTQVPSYCLNSKGEGAVRKILLCISNQFPDVSFCPALPAVVALLLHYSADEAECFEKACRILACNDSSRKLVDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYADWQRWLFGELPLSYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRAFVRDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALKQKGITVKQKSVSLSKRQFVHLAVHADNFHSEIVGVKEMRDIWSWVPERFALCQPLLLFSSLQHGYSLTRFYFQCEGREPTVLLIKTTQKEVCGAYLSTDWSERNKFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHPELTKPAPLEPTTVPPSPSHSVSSEPADRLSPFLATRHFNLPSKTESLFMAGGSDCLIIGHVAGDWR
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MHSFGYRANALATFAITILVIMCAMASFSDTFNTPSPTASVKVLNINWFQKQLHGNDEVFVFVAAEYETPKNSLNQISLWDGIIPSKENAKFSIHTSNKYRFIDQGSNLKGKEFNLTLHWHVMPKTGKMFTNKIVMTGYRLPEDYR
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MIISTKFFLSSFLALLIYGIASTALSIESTQSDDLSILPSTQDDFFSILASTQSDFLGAHNSARASIATSPRIPPVSWSNDAAAFAMRWITTLRDTRNCNMVHSGNRAYGENLYKWMGSPGLPSPNPAEAVKSWVNEKRDYRYASNSCAAGKVCGHYTQVVWRNTKRVGCASIKCPGNMLLVSCNYDPPGNWVGQKPY
The following text describes a protein:
Function:
Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells (By similarity). In the dark, tonic release of glutamate activates the G-protein coupled receptor for glutamate GRM6, its activation induces the release of G(o) protein and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization (By similarity). May play a role in metastasis suppression (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, axon. Note=In ON-bipolar cells is intracellular and located predominantly in the ER, and not at the plasma membrane or Golgi apparatus.
Sequence:
MGSMRKMSSSFKRGSIKSSTSGSQKGQKAWIEKTFCKRECIFVIPSTKDPNRCCCGQLTNQHIPPLPSVTPSSTAEDTKQGDAQSGKWSVSKHTQSYPTDSYGILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQSFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGKSVVSHVGDALKDHSSKSRGRLCAIGIAPWGMVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQLEKHISLQKINTRLGQGVPVVGLVVEGGPNVVSIVLEYLREDPPVPVVVCDGSGRASDILSFAHKYCDEGGVINESLRDQLLVTIQKTFNYSKSQSHQLFAIIMECMKKKELVTVFRMGSEGQQDVEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPVDTKVAEKEKKPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEECMAKALVACKLYKAMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQVAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILIPPTILFLEFRSYDDFSYQTSKENEDGKEKEEENVDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSPQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQNQPYMGYGRVIYCVDIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDRKTRIHIYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIVMRLSGRCRKKREGDQEERDRGLKLFLSDEELKKLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERENFMKASLQTVDLRLSQLEELSGRMVGALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADGYSMYRYHFNGEELLFEEPALSTSPGTVFRKKTCSFRVKEEDVKSHLDQPSSLHHTPGPSPPATPGRSRLALDGPLSTELRPGLDPGISAGELDPRADFKSAEVAPSLNTANVASTQLTVESTVSHPLRESKLARYYPGDLNTYKTMKSRSFVYSEGRKLVRGLSNWGAEYSSIMDQTWNSAEWRCQVQRITRSRSTDIPYIVSEAASQDEFEDEHRESLLAPQISRSALTVSDRPEKENLLSVKPHQTLGFPCLRSRSLHGHPRSAKPSPSKLDRAGHASSTSNLAVMSDAPEGQNTQQEKGNPETEC
The following text describes a protein:
Function:
Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
Subcellular Localization:
Cell projection, bleb.
Sequence:
MLAFTGAKLLERTRARRENLQRKMAERPTAAARSAPHAKRGREPLSEASNQQQPLLAGGEEKSCTKPSPSKKRCSDKIEVEASDLENKEPVDAAKPCSPKPAPRQMKPPAPAAISDSVAAPASLLSTGKASTTSSVKTRMQKLAEQRRHWDSEITDDVSESSHFSPMPSEEKPASPSKPPVSNASATPVGRRGRLANLAATICSWEDDVSYSSAKQNSVQEQPGTACLSKSSSASGPSASINSSSVQQEATCCSQRDGNASVKKDPTSNAADGPLLKASVSSPVKASSSPVRSAPFITRNCEVQSPELLHKTVSPLKTEVLKPCEKPTLSQALQPKEGANKEVCLQSQSKDKLATPGGRGIKPFLERFGERCQEHSKESPTCRAFHRTPNITPNTKAIQERLFKQNTCSSTTHLAQQLKQEREKELACLRGRFDKGSLWSAEKDEKSRSKQLETKQEVHCQNSPLKKHQIVSGTPSTSVSDKVAETPTAVKISGTEPAGSTESEMTKSSPLKITLFLEEEKSLKVASDPEVEQKTEAVHEVEMSVDDEDINSSKVINDIFSDVLEEGELDVEKSQEEMDQVGTESSEEQEDVLNISSMSLLAPLAQTVGVVNLQNVISSPELELRDSSLSAPSPKPGKFQRTRVPRAESGDSLSSEDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLSEKNGVFSGQVNIKQKMQELNNDINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEKRALLIDELNKLKSEGPQRRNKTAVASQSGFAPSKGSVTLSEICLPLKAEFVCSTAQKPESSNYYYLIMLKAGAEQMVATPLASTANSLSGDALTFPTTFTLNDVSNDFEINVEVYSLVQKKDSSGPEKKKKHCTLIIILVRVAIAVKRLMASPGGLSAVRTSNFTLVGSHTLSLSSVGDTKFALDKASVSPSSPLQDRVCCFGGPEIQIEGLIHSGALLTIFANFCNVSGFGAWHRRWCVLSGNCISYWTYPDDERRKNPIGRINLANCISHQIEPANREFCARRNTLELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVIVDIRLWQPDACYKPVRKP
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKSVSIKQLEGIVILDSDGKRIAVKYYNDKLIFKEEKLQNFNCSYESINYGMDTYNDFKTVEDQKLFEKDITEKIKKLGLNYSNETEILLLNKYVILCLSVNDIVIYIIGDDNDNEIILYEIIETVHQALNNITNNHIGKKQLIDKLDSVYLILDEIADSGIIMETSASVIINRLYMNESDIQEQHTPLNQAISSAKENIIRSLLSGA
The following text describes a protein:
Function:
May act as a modulatory subunit rather than a functional channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVFYVVGWALLAKKGYQERDLEPQISIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWADEDCPEGERGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCRPHYSFQLQEKSYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRQSSAPAPTATAAGSQTQTPGWPCPSSDTHLPTHSGSL
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MPSRCCRVLALILVSSLMIVSASATLEHLASALARLNISVTISPFSPRPPVVLSKAKMARQFLAAHNIVRSVFGLPPLRWNRKLARYARRWANQRAGDCALQHSPNSPYGENLFWSLKGNWGPREVVKVWADEYIFYDPIRNECINGEMCGHYTQIIWRKTEELGCGRVQCGDDKGFLYVCSYNPPGNIYFRGPFGGHFTNSIVKPPS
The following text describes a protein:
Function:
Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (e.g. pH 9.5). Inactive on phytoceramide. Involved in the regulation of turgor pressure in guard cells and pollen tubes.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
MGKFITTTLSPPLYARSKLLCFSLLYLFSTIFLFLYVSLSRNQCIFRYSPFDPIQAKLFSYPSSYGEHKYALPTHRSSCSSPIFFSDYWTVLKEIQSILSGSSPKENLRYINGKSESFGGNFSTQKRFSYFNHSNIDVEVPCGFFRDFPVSNSDRVEMEKCGLVVASAIFNDHDKIRQPVGLGVKTLETVCFYMFIDDKTLNSLFHHNVILKNNPSDYRVGAWRIIKISKSENLYLNPAMNGVIPKYLIHRLFPNSKFSIWVDAKIQLMIDPLLLIHSMLVVPEVDMAISKHPFFVNTMEEAMATARWKKWGDVDGLRIQMETYCEHGLKPWSSSKLPYPTDVPDTALILRRHGIRSNLFSCFMFNELEAFNPRDQLAFAFVRDHINPKVKMNMFEVEVFEQVVVEYRHNLKKIESSTYEEQEEEQKQESLRTIQKRRKWLDHESWSLNRSSCKNYLTDMWG
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLPPTIRISGLAKTLHIPSRSPLQALKGSFILLNKRKFHYSPFILQEKVQSSNHTIRSDTKLWKRLLKITGKQAHQFKDKPFSHIFAFLFLHELSAILPLPIFFFIFHSLDWTPTGLPGEYLQKGSHVAASIFAKLGYNLPLEKVSKTLLDGAAAYAVVKVC
The following text describes a protein:
Function:
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Sequence:
MPVDPAKLAALQKKSGAQSGGKGTPRRPGKKVAGRNISEDEKKLSATLKKFNAQEITGISEVNMFKEDGTVLHFPKVHVEGSVASNTFAISGPSQQKDIAELIPDILPQMGQDALLQLQQAAVQFSKLQEQAKKTAGGPDAAKEAGDDEIPNLVENFEDNVE
The following text describes a protein:
Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
Sequence:
MDSESFSNGSSYEYPGEYDQRDTDYRPKGKPISLSSFHSAALFILSVVLVLGVLGNALVVWITTCEMKRSVNTVWFLNLAIADLLCCLSVPFTIMEIILGQWPLGLATCKLIPSLLLINMYASVLLLTVISIDRWALVAKPVWCKNKRTVTKAYLACATVWLLALILTSPSFLFRNILTDFKGVSCVMHYNFSEEHIEKVKQFIAIFRFLMGFMIPFVALTVCYGVLVRKVSERYSKSGKTMKVVAVVIVGFFVCWFPYHIAGLILATHSPKTDIYKNTLQVDRILISFAIINSCINPIIYVLAGQDLKSIFRTSIKSVIKSVLEEEESQLFDPNKTKSHAENTVTSV