lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MALQLDLPTLHDLRVVLNADFLAALAALLLLAVILVPLCSYISLYAWSAILAFKLRSPPANWEKSIVKGVQANGTSTLFGFGFWQAAAVRRQLILQSNDPSYYSVTHVSRRSEIAISPEDRNTEFRNRAQDSGAPRRVIYGFFHPYANAGGGGERVLWAAVKDTLMYDDNIICAIYCGEQDLPTRTSPSTVLDAAVSNFHVTELADKELRKRIVFIGMRGRRLVDPKTWPRFTLMMQAAGSVWMAWHGISTLVPDVFVDTMGYPFAYPLVSWVTHVPVAAYVHYPVISKDMLATVSLKQSPVRAALAVAKLVYWRVFALTYTFAGSYCSVVMTNSSWTNNHMQHMWWYNHKAEHIKIVYPPCGTQALSEIAMSEETSARSPNIVYIAQFRPEKRHDIVLREFNKFYKEYTEKYPNQPAPHLTFVGTVRNDDDKSRVYLLRLQARDLVNPDSVSFVLDAPFDKVRDILRTASMGVNAMWNEHFGIVVVEYMSAGLIPVVHNSGGPKCDIVVPYEGQSTGNSGTLSAMPSSTSIRSHYEAVPPGPTGFHFNCPGSDPTTDSGPSYDGEPIGTLAETLMRAFELSESDTHNMRARARESVKKRFSNEQFGSHWQVRMRILEKLEQIRRGHRLTRGDFD
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGVREVVYAIERWFPEVERPKRHVPLKEKFMWTGIALLLYFVLAEIPLYGIPQQVQDYFATLRFVLAGRSGSLLTLGIGPIVTASIIMQLLVGSEIVRLDLSNPEDRRFYQATQRVFAVFMSFFEAFIYVFAGAFGKVNTGIGAFQTVSIPNGPIYIGIGLALLIVLQLGLASTLLILLDELVSKWGIGSGISLFIAAGVSQTVIYRSLAPVQSNQYIDPLTGEPALIGAIPAFIQHILKGDISGAIYRGGTLPDIVKLIGTIVVFLVVVYLESMRVEIPLSYGRVTVRGRYPIRFMYVSNIPIILTMALYANIQLWARLLANYGHPILGQFDSAGNPVGGFVIYLYPPRDIFHVINDPVRALVYALMTIFWSLIFGFLWVELTGLDARSIARQLQNAGLQIPGFRRDPRILERVLQRYIPYVTFWGSFTIALVAVLADFLGALGTGTGILLTVGILYRFYEEIAREQATEMFPALRKFFAK
The following text describes a protein:
Function:
Member of the pre-replication complex. Regulates endoreduplication. Involved in the coordination of cell and plastid division.
Subcellular Localization:
Nucleus.
Sequence:
MSSSSKIDSEKPVMVSESLFSTKTPIKTVKRQIFSSSPKPESVIKLPERFEILEEFFNGLDTAIRLLKLKGSSTTYANICPKIEYLTNRIFSYDHLAQMKHIYPEAIELKRVLKFVEDTCCMKPRLHIKLNTDAIVVEDTICGTKYMELRKVFHSKLVDFRKAHPKDEIPKELLPEPFNSPQRDSYSGIVSVGLGEPKLEVGGFDVHMEEIEQEEQDVNKVIPDSTLSHIESRIVETPVKDLSTPSKDLSTPIRLMSATPTLQLSKRCIELTPEGGDDNSLRSTNSLARGPSRSLNFDTFEEDAIEKDDIGNESDDKGINYEEDGLLQSVKGPSRSLNFDTLEEETIVKDDISNESGDEKSNYEGDNASDDDSLLQSMIERPKTEPEKHNLPQLVNLIHRVFHSTNRTVITKEELLYKIIANQINITDRREVEEQLSLMLQLVPDWISETKASSGDLLVRINKMSTAETVRARLEEATSHDISLIY
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MIRTRFAPSPTGYLHIGGVRTALFNWLLAKQAGGQFILRIDDTDAGRNVDAALKPILDGFRWLGMDWDEGPDVGGPHGPYFQSERGDQYRAAAEKLLADGHAYRDFAKPEELQTLREEAQKGGEAFVYDRRWMAEDEATAAKFEAEGRQGVVRLKMPREGQCVIQDLIRGEVVVEWASEQDHVIARADGSPLYHLASVVDDHELKITHVVRAAEHLPNTARQVFIAQSLGYELPIYAHLPYVAEPGGSAKLSKRKLDKYKKNRDFAVLLAHGEKIAERCNMQVDADTFNPVLVDFYREIGFLPDALLNYLLLLGWSLDGETEKFTIAEMIEKFTLDRVNKAPASFDPAKLQSFQGDAFAELSDEKRTELVRPFAVAAGFVADGDADETLKAVLAAAGDRLKMAGDIVDFDYCFVDDYSVDEKAYEKRLAKADGAKELLAKLNETLKAATEFDAANVETTVKSFCESEGIKIGQIIHALRVATTGAASGFGMFDTLAVLGKDKVTARIEKTIAGLS
The following text describes a protein:
Function:
May be involved in the response of cells to X-ray radiation.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Gene model based on mouse cDNA data.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAFSGIYKLDDGKPYLNNCFPARNLLRVPEEGQGHWLVVQKGNLKKKPKGLVGAQAERRESLKATSFEFKGKKESRRENQVDLPGHILDQAFLLKHHCVRKPSDLCTINAKENDFKHFHSVIYINASENLLPLEAFHTFPALKELDLAFNGIKTIYVKYGDFKLLEFLDLSFNSLTVEAICDLGILPHLRVLLLTGNGLTSLPPNLAVAEQEASVTSLTSKRYILRFPALETLMLDDNRLSNPSCFASLAGLRRLKKLSLDENRIIRIPYLQQVQLYDESVDWNGGRGSPHKEPQFMLQSKPRMLEDSDEQLDYTVLPMKKDVDRTEVVFSSYPGFSTSETTKICSLPPIFEILPVKSLKARNQTLAPPFPELRYLSLAYNKIAKEDAVLPVALFPSLCEFVFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKPKHHVLMSRKESWKVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHKQYLEAKRLLKEFQARYRQLVSGSLRTVFGTTPLPMACPALSESQPKFGHFLEFMDEFCQEPTASDSQG
The following text describes a protein:
Function:
Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis (Probable). Probably required for both cortical and vegetative peptidoglycan synthesis (Probable). Although not usually required for cell division, in the absence of PBP 2B (pbpB) it becomes essential. Confers resistance to oxacillin and cephalexin.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Forespore inner membrane; Single-pass membrane protein. Forespore outer membrane; Single-pass membrane protein. Membrane raft; Single-pass membrane protein. Note=Localizes at mid cell; localization requires FtsZ and PBP 2B (pbpB). Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Sequence:
MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFDDMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYKVSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRGQIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVKDDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEELKKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLTIDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNKDKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSVTRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKSSIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADVWHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGTENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN
The following text describes a protein:
Function:
Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins.
Subcellular Localization:
Secreted. Host cytoplasm. Note=Translocated into the host cell via the type IV secretion system (T4SS).
Domain:
The FIDO domain mediates the phosphocholine transferase activity.
Sequence:
MVKIMPNLPGLYFLQAYPSEEIWRLFVDGRFWSKENGWRGYESREPGCLNAALESLCSIALQVEKSGEEFELSVDLIKRIHKKCGKKVEELQEKNPGELRTDEPVSFGIPAGRASIKGIEEFLSLVFLTEGGAEFGPGKAGPFGPRFDKNYFKNLNPEQIPDLAKQIYFDMCKYGHSNTNHFYLAVMKNVDVYLEKITQSYNKEIKTAETLDEKLKIIVKHIRMYEVLHPFRDANGRTFVNNLLNILLMQQGLPPATFYEPNVFDLYSAEELVVVVKEAIFNTVEIIEQSKRKTPITLYGYHSSLEEQTKFRDMLDSPSYEKIKHMDFSDLNPEKLHLKTQKCLSSLNEQYPLHRGAIYLSDPGEIKLLLSNRNESQINQQIEQGAPPIYVGKTPAHLAVISGNMAMLDELIAKKADLSLQDYDGKTALHYAAECGNMQIMGKILKVVLSQEDAIKVLNIKDNHGKTAFHYAAEFGTPELISALTTTEVIQINEPDNSGSSAITLAYKNHKLKIFDELLNSGADISDELLDAIWARKDKETLGKIIAKNEKILLNKEAFRIAISLGSVSLVKKFLRAGVDIDIPLTKDKATPLMLSINSGNPKLVSYLLKKGANTRLTDTSGNSVLHYVFYSKAENREALANIITEKDKKLINQPNANGNPPLYNAVVVNDLKMATILLEMGARVDFEDRLGNNILHSAMRRCDLPIILDIVKKDSTLLHKRNSERRNPFHQALHEMHTFPSSKETEEIHFMNLSDLLLKEGVDLNKKDIKGKTILDIALSKQYFHLCVKLMKAGAHTNISSPSKFLKNSDANSILERPFKFKNDLKKELDNNPLIAMAQINDLYVQIKNNRIRTPTGYAPKEGVSFFKGKSNDAKAHDEVLSVLKELYDSKLTEMLGNLPGEGLEEIKRSQKFFDGELKLLIKNQDISRKVDKKSIQEAVGTSLKLKW
The following text describes a protein:
Function:
Plays a role in female and male fertility. Involved in distal reproductive tract development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MCHVIVTCRSMLWTLLSIVVAFAELIAFMSADWLIGKAKTRSSAEPGEQGGGSPEPYHPTLGIYARCIRNPGVQHFQRETLCGPYAETFGEIASGFWQATAIFLAMGIFILCMVALVSVFTMCVQSIMKKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIGYCGHYASAYKPGDCSLGWAFYTAIGGTVLTFVCAVFSAQAEIATSSDKVQEEIEEGKNLICLL
The following text describes a protein:
Function:
Upon host (human neutrophil) infection interferes with productive FCAR signaling, inhibiting secreted IgA (SIgA) effector functions and probably avoiding neutrophil activation. Inhibits the SIgA-mediated oxidative burst by neutrophils, decreases generation of ROS (reactive oxygen species) by neutrophils and reduces chemotaxis by neutrophils, all of which are SIgA effector functions used to stimulate the immune response. Does not block SIgA-binding to its receptor (FCAR) on neutrophils, but it decreases SIgA-stimulated phosphorylation of cytoplasmic proteins, including phospholipase C-gamma and MAP kinases, all actions that may be advantageous to the pathogen.
Miscellaneous:
MISCELLANEOUS: Preferentially encoded in ExPEC strains (extraintestinal pathogenic E.coli).
Subcellular Localization:
Cell surface. Note=Accumulates at 1 cell pole in the bladder of mice infected with this strain, in overexpressing bacteria the protein is found all over the cell surface but not in the secreted fraction. Human blood sera from clinical patients with urinary tract infections reacts with antibodies to this protein.
Sequence:
MKKSLLAVMLTGLFALVSLPALGNVNLEQLKQKAESGEAKAQLELGYRYFQGNETTKDLTQAMDWFRRAAEQGYTPAEYVLGLRYMNGEGVPQDYAQAVIWYKKAALKGLPQAQQNLGVMYHEGNGVKVDKAESVKWFRLAAEQGRDSGQQSMGDAYFEGDGVTRDYVMAREWYSKAAEQGNVWSCNQLGYMYSRGLGVERNDAISAQWYRKSATSGDELGQLHLADMYYFGIGVTQDYTQSRVLFSQSAEQGNSIAQFRLGYILEQGLAGAKEPLKALEWYRKSAEQGNSDGQYYLAHLYDKGAEGVAKNREQAISWYTKSAEQGDATAQANLGAIYFRLGSEEEHKKAVEWFRKAAAKGEKAAQFNLGNALLQGKGVKKDEQQAAIWMRKAAEQGLSAAQVQLGEIYYYGLGVERDYVQAWAWFDTASTNDMNLFGTENRNITEKKLTAKQLQQAELLSQQYIEKYAPEAWARMQKLKAQSAVKTGNK
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
Subcellular Localization:
Cytoplasm.
Sequence:
MAATFFGEVVKAPCRAGTEDEEEEEEEEEEEGRRETPEDREVRQQLARKREVRLLRRQTKTSLEVALLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAFCVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSESTGSLPSPFLKALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVMKLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT
The following text describes a protein:
Function:
Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two cyclic-di-GMP (c-di-GMP) control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD. PdeR acts as a trigger enzyme that connects modules I and II. It inhibits DgcM and MlrA by direct interaction. Inhibition is relieved when PdeR binds and degrades c-di-GMP generated by module I.
Sequence:
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVITSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSGNAYEVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTDSITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVVRQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKRA
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MRLAVKQESFRLEVLMSRLQSECFTFCCKNLSSKELTMDEVKCVERCAVKYLQASDIINRALDKGESGGGAVKQMLKL
The following text describes a protein:
Function:
Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA-dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit induction of sporulation by SDF-2.
Sequence:
MTTFEEAAQKVKEFTKKPSNDELLSLYGLYKQGTDGDCNISEPWAVQVEAKAKYNAWNALKGTSKEDAKAKYVALYEQLATKYA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 1800 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MNFHTARISQVGVISRALLSSVSRRWIHVTPISLNNSGGSLFGSITENKPKEGKNRGDEDAGSFSNRLAIASDSSGEAPEVNRDSITIENDKLLQQHIISLQQPEQLASQSLLSPLKREIYEANCKINGGFYKKDTIVKLPNSSERYKLKLTKREIEVLEPSVYAQSYRIKSSMKKATLLLRLLGGLDVMKAISQCHFSNKKIAREVAELLQKGVKDGQKLGLKPEDLYISQIWTGSDGFWRKRVEFKARTRIGIISHPYIHVRCILRTKSVTKRRLAYEAHLKEQKRAPWVQLGDKPIRGVTGGVYKW
The following text describes a protein:
Function:
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTTSSKVAIKPLEDRIVVQPLDAEQTTASGLVIPDTAKEKPQEGVVLAVGPGRFEDGNRLPLDVSVGDVVLYSKYGGTEVKYNGEEYLVLSARDVLAIVEK
The following text describes a protein:
Function:
In the mitochondrion and together with LipL1, involved in the lipoylation of the E2 component of the branched chain alpha-ketoacid dehydrogenase complex BCKDH-E2/BCDH and the E2 component of the alpha -ketoglutarate dehydrogenase complex KDH. LipL1 is responsible for catalysing the activation of lipoate, forming lipoyl-AMP while LipL2 is required but is not capable of catalyzing this reaction. Although its role is unclear, it may catalyze the transfer of lipoyl groups from lipoyl-AMP to BCDH and KDH or act as an effector protein.
Subcellular Localization:
Mitochondrion. Plastid, apicoplast. Note=Predominantly localizes to the mitochondrion.
Sequence:
MRIIKCLDQIFRPVLPNVNINNIQKNKKINILYFIDVSKFHVFEQLLLEESLFRISNNTTEGLNNIGFVIVNNTCEEMNESKGNECIFNNKKCVILGISNKIKDHIKDTNYIKENKISLIKRFTGGGTIYINKNSLLVSLILPHKFEKNKKIYPSNITEWSYNYFYNTSKQIYDKTQINNEKNSLNKNHILFNQYFNYYENDYVYKDYDEHNKNIILKKVGGNAQSFARNYFVHHTSYIWTCDYKEMNNILLNPSKQPIYRNKRKHQHFLQSIKLCLHDDIHTPNIFIEKLIKHIKHIINYKNITDQHDYWFFNKINLKNINDHILRNSEHFDDIYVADMNLLQCIFNYYNNSSLFNNMRSTYFLDLEGKKVSDRYYDIPTYFL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDTPSPDPLPSPLPGEEEKPLALPPPVPRGRRGRRPGGATSSNRTLKASLPRKRGRPPKSGQEPPLVQVQGVTAPVGSSGGSDLLLIDDQGVPYTVSEGSAAGPEGSGPRKAPHFCPVCLRAFPYLSDLERHSISHSELKPHQCKVCGKTFKRSSHLRRHCNIHAGLRPFRCPLCPRRFREAGELAHHHRVHSGERPYQCPICRLRFTEANTLRRHAKRKHPEAMGVPLCAPDPGSEPPWDEEGIPATAGAEEEDETEGKGEPA
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA); A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA.
Sequence:
MNLLIDNWIPVRPRNGGKVQIINLQSLYCSRDQWRLSLPRDDMELAALALLVCIGQIIAPAKDDVEFRHRIMNPLTEDEFQQLIAPWIDMFYLNHAEHPFMQTKGVKANDVTPMEKLLAGVSGATNCAFVNQPGQGEALCGGCTAIALFNQANQAPGFGGGFKSGLRGGTPVTTFVRGIDLRSTVLLNVLTLPRLQKQFPNESHTENQPTWIKPIKSNESIPASSIGFVRGLFWQPAHIELCDPIGIGKCSCCGQESNLRYTGFLKEKFTFTVNGLWPHPHSPCLVTVKKGEVEEKFLAFTTSAPSWTQISRVVVDKIIQNENGNRVAAVVNQFRNIAPQSPLELIMGGYRNNQASILERRHDVLMFNQGWQQYGNVINEIVTVGLGYKTALRKALYTFAEGFKNKDFKGAGVSVHETAERHFYRQSELLIPDVLANVNFSQADEVIADLRDKLHQLCEMLFNQSVAPYAHHPKLISTLALARATLYKHLRELKPQGGPSNG
The following text describes a protein:
Function:
Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans. Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance. Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs). The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing. Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (By similarity). Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis.
Miscellaneous:
MISCELLANEOUS: May serve as an anti-inflammatory target.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLLPKKMKLLLFLVSQMAILALFFHMYSHNISSLSMKAQPERMHVLVLSSWRSGSSFVGQLFGQHPDVFYLMEPAWHVWMTFKQSTAWMLHMAVRDLIRAVFLCDMSVFDAYMEPGPRRQSSLFQWENSRALCSAPACDIIPQDEIIPRAHCRLLCSQQPFEVVEKACRSYSHVVLKEVRFFNLQSLYPLLKDPSLNLHIVHLVRDPRAVFRSRERTKGDLMIDSRIVMGQHEQKLKKEDQPYYVMQVICQSQLEIYKTIQSLPKALQERYLLVRYEDLARAPVAQTSRMYEFVGLEFLPHLQTWVHNITRGKGMGDHAFHTNARDALNVSQAWRWSLPYEKVSRLQKACGDAMNLLGYRHVRSEQEQRNLLLDLLSTWTVPEQIH
The following text describes a protein:
Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates PLCG1. Promotes phosphorylation of AKT1 and CBL (By similarity).
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes internalization and degradation; [Isoform 2]: Secreted.
Sequence:
MPRQLLSGTVLLGAAFLLAGSTSGSKLKVPVLSVNGRQHVVQAGQTLNLTCRGEMLHSWSLPEALSKDSKRLNVTKYACGRNGTQFCSTLTLSRTQANDTGRYSCRYPTSPVKKKRESIVYVFINDTSNPFVEMHSDIPKIIHMTVGKEMIIPCRVTAPNIAVTLKKIPRETLIPDGKTIIWDNMRGFRIPEATYRFIGLLSCETTIGGHKYSTKYLTHRETNTIFDIKLSTPRLVKLLKGDSLAINCTVKAAWNTRVQMTWTYPGEAMKRGSVTQRIDQKNREANVFYSILVIDKVRDIDKGQYACHVKSGPSNKLVNTTVIVYDKRFINLKRRRKTMLEAVAGRKSYRLPMKVKAFPSPEVTWLKDGLPAAEKCARYMVKNYSLIIKDVAEEDAGNYTIILSLRQWNLSKNLTVTLKVNVKPQIYENAVSSFPDPNLYLLSSKQVLTCTVYGIPPPKITWMWYPCRQNHSKTRRGFCSRTDGSFNLKTGSNIGNRIQSIIERTAIIEGKNKTASTLVVAEAKSSGIYSCVASNKVGKAERNVSFLVTDVPSGFHISLEKVPIEGENLVLSCSANKFMYKDISWILPRTVTNQTKARKALNKEYSITLTLTIRNVSLAHSGTYTCRARNIFTGKEVLQKKDVSIRAQEAPALLRQLMDQTVNTSNSAMLECQVHGIPEPQITWFKNHEEIQQESGIILGPGSRMLFIERVKEEDEGLYQCIATNLKGSVESTAYVTVQGTVERSNLELITLTCTCVAATLFWLLLTLFIRKLKRPYFSETKTNHYLSIIMDPDEVPLDEQCECLPYDASKWEIARERLKLGKSLGHGAFGKVVQASAFGIKKSPTCRIVAVKMLKEGATASEYKALMTELKILIHIGHHLNIVNLLGACTKNGGPLMVIVEYCKYGNLSNYLKSKRNFFSPTKDPSLQGELMKDKKGIEPVEGKKQRLASVTSSESFASSGFQEDKSLSDAEEDEEDAAELYKLPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDARLPLKWMAPESIFDKIYNTKSDVWSYGVLLWEIFSLGASPYPGVQIDEDFCSKLKEGTRMRAPEQATEEIYQIMLDCWRSNPNERPWFSELVKRLGDLLQASVQQEGKDYIPLDTIFTAESGFPPASDPLCNEKFPVPSPNCRSTERARYINTFKIKPPQRIKTFEELPIKEKLVFNDYQADSGMVLASEELKRFTWTGSKQKWTLFGMKGVSRSKESGLSGITKPRSFCSFSCDQLSESKRRYTYGNTVLEKMKACHSPPPDYSSVVHYSQPSI