lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.
Sequence:
MMSAGGDTPEDVRKHGYLRKLKARWTLRQDYLYVGTMKKRYFVLHAKSSAGAARLEYFDNEKKWRHGAAPKRTIFLHHCFNINKKDDGKHKHMIVLYTRDECFSLVADTADEHDTWLAVLKDLHESGSQEGFISKQNFEHVWQVTLKPKGLGSSKNLTGQYRLCLTANSITLLKMNSEEPAMDFQLTQIRRCGHVESFFLMEVGRSAVTGAGELWMQVEDTLVAQNMHEAILSSMKAISSDDEFRPRSRSSGSSNPLPVPAGRRMTGTVPTMALSHTLPTRSRMRCDSLPTAPGRGGARYRTTSEGEMKTNSPVSPSRNRTRLSAIHQRSSPRSVIGSHGMFNRSVSAAGSLSQSPISGSPLSPSPTGFASDQYAHPLPISRGLMEYTSDGSTVSMDEYDSSPASSDHYLQRYVPSGRSLTPDSPSHTPIREEGGGDGYVPMAPAFPGGYPTRSAPQDVGYPTRSTPQEGSYMPMSGGIGRGSPTTLSSRLEDGYMPMSPGTPPTTTDMRLDESYMSMSPSSVSAPRQIVTRRPANGDPYVTMSPGSRSPDHAEYMQIWANQRPDNRQNNNNNDDSSYMSMSPVAQALPNTSIPDTYIVYSPSAESSPPAAVIEKGQMEATDGYVHMEMQPRRTGTETARRTGQTTQDDNYMAMDFGAKGSERLSASERLSSSLPAEHHLSSSPGGTNRPTTLRLTNQHEYINVTPTAAPNDGYAVMDYISGDGGVASSDESRTSAADGKTSTSESGIYSGEESGRPRSPGEYVNIDYSTKGADGPGSEGDGSEYMNLTYPSEKPSPKIHVSDYSLMAPVSIAERPEKGAGKSPGLLKQDSLTSEDEGLSSQGVIRHSPVFSTSADISVVKNSKESPEGGASPVTVETAAGASPVTAVTGASPVSGSSYENVSLGSRQGGGLTQSSQPGSRHSSVSSEKELNYISLDLPSDEGEGAAGDDNPVAKATRSPRSSVSSEDKADENPYASIDFTKSEGLRNTSPKYHDRDGRF
The following text describes a protein:
Function:
Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, in contrast to cysteine synthase cys11, this CS-like protein seems not to function in cysteine biosynthesis, at least under normal growth conditions, although the transcript is produced.
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MAKKYQDLASGIAMGAVFMYLLRRLYESLRVKSSADSLEEDIVNGVEGLIGNTKMVRIKSLSQATGCDILAKAEFLNPGNSPKDRVALQMIRTAEENGDLVPYQSNAVYEGTAGSTGISIAMLCCSLGYDSRIYMPSDQSKEKSDILELLGAHVQRVTPAPIVDPNHFVNTARRNAANHTVDESIPGKGYFANQFENPANWQAHFNSTGPEIWRQCAGKLDAFIAGSGTGGTIAGISRYLKSKDPSITVCLADPPGSGLYHKVLHGVMFDLAEREGTRRRHQVDTIVEGVGINRMTRNFSIAEPLIDMAYRVTDEQAVAMSRYLVTHDGLFVGSSSAVNCVAAVRLAKKLGPGHRIVTLLCDPGSRHFSKLYNEEFLRKKNIVPQVPSSLDFVEA
The following text describes a protein:
Function:
Not essential for the accumulation of ER body components, including PYK10.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGSAAELTEPTTGTEKLHQPIEVEEDDEQIVDLERKTFRHGKGHDTSVDSSTITNTSSSSSSSFSGDGGTEETPDFHSNGDGEHTDLVNLEVPELETEIVFHQEHDDGKNCIVFFDGEQGSESAGAIPDAHEESQTADLNGEQTQLEPENGSTSEDNERSREIEEVLDGDVSKDLDAVDPLAGEVIEEEVDFEDVEYHDVENMMDKQETHDLYCPNCDSCITKKVILKRRKRKIRRHELGDSKRPHLTEPLFHSEDNLPSLDGGENSANESFVFKCLSCFTIFIPKGVSSKPIPPRQGVEGLKIQPNPQVEATGDSNWFSSIFGLNKKESAIQQGGASSSVLEANPPPRESIVPVVNPSRGNLSPMRKDTTGSAVVQPDAATSIQVAKSNDTSEIVNNGAIVGDGQKFLAPMVEEQTQQKIDNDDSSTADGNHTSDKGRLSPIQPSHGMSILNTVTNGPDGLKVETTIHEEGAPLLFEGKDTPDTSTADFGLTKVTGVMDTGDRGVITGPANPEIDISAGNLLEEGSLREPLMRRVVVQGRKLEILKSIVYGGLLEAITSLGVISSAAGSGASMLNILVLGLANLLGGLILIIHNLQELREEEPIRTTTEDNQTNGREEEEGRYKRLLGRRENFTLHATVAILSFIITGILPPVVYYFSFSEKHNKDYKVASVFGASLFCIVLLAIAKAHVRYPRGSYLKSILYYGSIAVSVSGISYVVGNFLEQLLEKHGWSDGSETPVGQMMLSSLMGRKAGFGYSSSY
The following text describes a protein:
Function:
Polymerase alpha in a complex with DNA primase is a replicative polymerase.
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MNRPKREKKSITDVSTLKSLEQIKRARDGEKRTDQLQEEDDERKRLEQLKEQETEFDKEERKRKNRDFIEGDSGYRETSDNEDEDEDEDDDGDNSDDDYSLDEDDEDGGGDGENNDSDQEEAIEVGRKKKRQVKKKSKKDENGEPKVKTPRVKKTKEKKNEIVPEKNRIIQFINNPTESKSTSNNESFFFDKLKKSNSNTLNSTNSTLNSNELSSGGTMSSLDIESMLNDLQSAPDSELDLEKLKEKQLELEKKLEKEALLNKPTISTETIITEGVELDDNYEFDFDFNNPITTNNNNNNNTKTTTTTTTTTITNKNLNKVNSMSLPTRPQAQQFISPKQTNQEDWWSKTGVDSVVLVKKLEEIMPKNSDLLKMNMDGSLDFFLLTTEEDKQGRIILFGKVKLQASKSNKPGGGGGATKQTSITDEPVTKVPLKYASCCIIIEKMERNVFFLPRDYKLDQDGESTTIQVTDTMIEAELKQLVDRSKIKDYKLKKVKRTSAFDYSVPHKNGPVGEQHYVWKLSYPSNQMVFPNDIKGSTFRCAYGITSSPVELFLIKRKIMGPTWLTVSGITLNFDQKKSFARYEATVKSFKSIKPSMYKNEPSPPLTVMSISTKSVMKGSSHEVVMISSVIHESISADGPTENQDSIKYITAIRPLTGQVFPPDFQKPGASTTKQNVTICTSERNLLSFFCETVLNADPDVFAGHNIIGYDIEVILDRLEKLKVMEWAFIGRLKRSSFDRFNHISGRLICDSYLVCKEFLPKEKNYSLVELSKNQLSINKPEINYLSIEPYFETTKKLNIFIEINENDCYIIFLLIFKLLVFPLTKQLTNLAGNQWDKSLKSNRAERIEYLLLHNFHEKKYLLPDKIYQKSSSSGGGGGAKDKDNHAAYSGGLVLDPKIDFYDRYVVLLDFNSLYPSIIQEYNVCFTTINRVKRDDGKWEEAMPPPSSIEKGILPKVLHGLVSKRREIKKRMEQEKNKIIKAQYDIQQQAVKLIANSMYGCLGFSHSRFYALPLAELVTRKGRENLQKGASIVNKMCYDVIYGDTDSLMIYTGVGTFNEAETIGKEIQKKINDQYRGSVMEIGLDGIFKRLLLFKKKKYACLKEFRIDSTTTKCERENKGIDIVRRDYCDLTKDIGQWVLNLILGGEEKIALFSLIKEYLESVQQQIKDNTLAVEKFIITKTLSKQPEEYNDADIQPHVQVALQMRAKGLHVQPGEQVPYIITHGNSSSDIKEEWHHRARAPSDVESIQDVDIDWYLSQQILPSIQRNTGPIGMEPHELAQWLGMTGTKYQKQFDHLQQQSNQDFKPRYTLSTEDLRYKQCKSFNFECPYCGQNNEFTGIVKIDSEGKSESGFDCNQCHAKIPLKKLANQLQLNIRTYLKQYNDWDLRCTECEKVSKNYKETSYRCARPQCRGKMIQIMTSSKLFNQISFFSKLFRNDLSNSDNTTTIIPNEDQNTLKQAKQIIDSFLSKFDQYNVNLNSLLTPSQTLDSFNNYLASSRASIQYPILNK
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MFEQWDALCAVLFSFSIAQELKTHADIVNQKGEKIGKAELIQTNSGVLIKLEASNLPPNAELAFHIHELGKCDPPDFKSAKGHFNPFKKKHGLLNPEGPHAGDMPNIHTDDKGNVRVQVLNPFVTLKKGKKNSLFKEGGTALVIHGGPDDYKSDPAGNAGKRIACGVVK
The following text describes a protein:
Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Subcellular Localization:
Cell membrane. Cell projection, lamellipodium. Cytoplasm. Nucleus.
Sequence:
MGGLKDELLKGIWHAFTALDLDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNKFILEKVQDNFDKIEFNRMCWTLCVKKNLTKSPLLITEDDAFKVWVIFNFLSEDKYPLIIVPEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKDGLSVWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLIKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKLLAEQEELERQMKELQAANENKQQELETVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVMKEQALQEAMEQLEQLELERKQALEQYEGVKKKLEMATSKTKSWKDKVAQHEGLIRLIEPGSKNPHLITNWGPAAFTQAELEEREKSWKGKKSTE
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MADQRPLMTWLEANNYESFLQEDIFSFLDQSLFVDPHSSFIDPFKDFQTQNWFSLQDSIVNHISTTFAADHTFLASLDLEAISSTFSLDISSGWWNENNGNYNNQVEPNLDEISRTNTMGDPNMEQILHEDVNTMKEKTSQKRIIMKRRYREDGVINNMSREMMKQYFYMPITKAAKELNIGVTLLKKRCRELGIPRWPHRKLTSLNALIANLKDLLGNTKGRTPKSKLRNALELLEMEKKMIEEVPDLEFGDKTKRLRQACFKAKYKRRRLFSSSS
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGAGAGAFASTVPGLYNVNSPLYQSPFASGYGLGADAYGNLPCASYDQNIPGLCSDLAKGACDKADEGALHGPAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKDEGPAAAAPEGAVPTAAAAAAADKADEEDEDDDDDDEEEEE
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MASESITMWPQISPEEQLQYERCTRLMELLRSEGNAQVTSRYRLEECVDIVETFSFSTGLDFDQAARILMALAFDIQAAHRSFWIHRFKDTLEDDPYAPTGQNPHATDLKDLYGVRVAMIQQYTGVDETHAIVALRKSRWVVEKALACVYSDPTAQPTLFVNDLDLLFAQYQDMQTGKINLRGPPFFSSVILPRQPTEAFKVIAILSWYMQAECFGEVSLREFVVGMLYLRTDNMQDLQDRLFQIGYQLKIPEVYEKVYESCFVWFAGRDQWRMSTSQAICLWTMLFDELDLEPDPEADRVNMRWPLRNDWFRYLRRNPSAPTIDKTTWMHILKFATVIKPDLSNYDDVDWPFLIKDFVDELITIKTLSPDSPDSPANLSGN
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Subcellular Localization:
Nucleus.
Sequence:
MAARPRGDDTGAQTAVFQTRPPRPLPFPRGAGARLSGPEVGQATDRGRGAARSGGPQGASPDPSATAAPWPPPPPPPPIWSPKINVKPGQNILETLQNCFEESRGWDPSLESSSPAVSPGPTGLEDVRYLSPGKEASPVQPAQIRSPEESSSSILASPRAAGEIGDSVRTPETHGGSPVPATVSAKSTPAFGGTSESPEKAAEVPRGAEDFYLAVGPLDLLIEEEEEEEEEEEEAALPSKTTSPVHSRERIRPPVGSADRRPPSPAVELKSKKRLNFNGKAAASVGKEAGIRIERPENSQKKESAVAPEESARGSVSHTPKNEPKSKGKVSSIFLDAVKVGNDRPGFYRHSPAAPPRSPSPPPSGVNPLPDDEFIIDESDSHASTSWISIPRKSTRPGNRGPEPSAARTQARERTRPEAQQAGRPKTPAGPGEKGGHGRDGDDSDTEGGEGTSGEVRRSPRSEERSRGRERSDSDRSRSGREGVGRPSVRHQAVLSTAARLAEEVEPGPRHRGEEPEARADRRHADGERPPGRRAGRETRDGPRSASRSDEEPASSRPDGRGDRSPERRNPGRLPQRGGKPRGRGDGGRPDAGGSPRRSVTPSSRRPRGGSRADGSGGDLDRNGEEESTGQKSPPGGKRKNRDPVEQIQASKKGSPKTPSAGVPRKKRPKVVTEGRPEDDPHPARGRAEIRTSRRASRPPSDWWMLKAERSGTERKEGPTPKRSDRDEPSQAPEVGETGLAPHDALRASVSPSRVAARRPPAPSSRETRRPSAKPKPGAETRQRPRRRKQDPGKMTRSERREAERSVGENGRTVGSGHRPAEEREGEAAGSETPGVTNPTGQNCPPPGSRDPAMSAGYSNLRCPSALSSASSGIASRKESPAARGKRTNRGGRKRPLPPAGERTPPAELQKSAGPARPEPEKLVYSSSGVSDPGNVLAGDEPSGSGAGGSRAGSDSEPSPRSKGRRGSAAKRKARRAGAAGLPEESLESPEFAHPPEEAKTPRGTLRSPLTPDTTGPVTSTVEGSGPARSRITRTFPPGDEVRVYEQEDLSSDDAGYPSDEPSRLAPNQKAKRKFVLPTDTPNVRRTKRIRVKPLEYWRGERVDYKVRPSGGFEIHGIISPDAVSPYRGASGKMEKLKKLAKEKGRPLAKAKSRNAIANLNLSLGDPSKPTTVWCHDTNREVLLSCVRPKGTYTYCLGDDSLMVYKSLNTSSFSAGQLVLGPFKVKGSQHVCFDTLVFYIVQGELICTLRKTPYYLTAGDTFYVPPGNLYNIQNLLNQKSVLLFTQIKSERLEGVRLESDADDEG
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MRERAWLGGLRRPPNPLVSGHRAARGALRSMSEALGARRRLAWLNAADLSIGTTLDVRRTAEELADFTVPELADGAAVDLLDSVLRFQEGDRVSGGGAPRLRAMAVSEVEGLNLAPDPVGELSVHTADRLGQRCLTTRRPVLVSRMTRADFAVIAPSRESSDIMRRAGVHSYLAVPLIARGVLLGLADFVRAGHRAPFNRTDVALAMELASKAAVCIDNARLYGRERDHVVTLQRALLPRSSPSTPGLAVTSCYDPAADPAAVGGDWFDVVALPSGRTALMVGDVMGRGLAAAATMGRLRTVARTLMALDIAPERLLARLDLAARDLEEDQVATCLCAVYDPYGNTFRIASAGHPPPLLTGPDGAVSFLDVPAGAPLGTGVIPYDPVERPVPELSRLTLYTDGLIRSRTADLGTQLERLREAVGGGVPEDGTECRAVAERVGGDRSDDAIVLAALARPLGPECDVYVRALPPDGKAAGQARTAVREQLERWGLQELVDTTELVVSELVGNALRYGNAPGELRLLRHERLSVEVSDSGPDLPQIQHADVSDESGRGLQLINMMCRRWGSCRTPDGKVVWAEQDLPVRAGAPGPS
The following text describes a protein:
Function:
May be involved in cell proliferation and cell motility.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASRRMETKPVITCLKTLLIIYSFVFWITGVILLSVGVWGKLTLGTYISLIAENTTNAPYVLIGTGTTIIVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELIAGISGFVFRHEIKDTFLRTYTEAIQNYNGNDERSNAVDDVQRNLRCCGVQYYTNWTSSLYWHDHGFPPSCCANNSDCNPEDLRNMTINFTKVNQRGCYELVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANQYEMV
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MPEFLDIKHLDAGYGRSQVLFDVNLGIPWRGGVAVLGRNGAGKTTLMKTIVGELPAWKGEVAFDGRDISRRATQERVRAGIGYVPQEHSVFARLSVRDNLAVGSLASSKADAVDHVLSIFPKLGQRLDQPAGTLSGGERKMLAIGRAMLGDPKLLLLDEPTEGVWIGVIEEITERLIELAKEIAVIIVEQHLDLALRVADYAYVLDRGRVALQGEAGEVRGNPELLRYLAP
The following text describes a protein:
Function:
Serine protease that functions in the melanization-mediated immune response. Preferentially, cleaves substrates with an arginine at the P1 site. May be involved in the activation of the prophenoloxidase cascade upstream of CLIPB9; does not cleave prophenoloxidase.
Subcellular Localization:
Secreted.
Domain:
The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Sequence:
MSSAVLLLLVCGCALAVLSPVAYGAPMDTDDRPVWDSIRLCDIPNEPNPGQCMLPAECVAYGKINDVSSLSSIERFSFIKQIQCNGSDTVPYVCCPRDSDAYREPYVNETMVPKNRVASRIAFDADSCGIQSYVAKIRGGQLAEIDEFPWMAMLLYERDNNALTQGCGGALISRTYVITAAHCVTGKNFQQTKGRLKFVRLREYNIHTNPDCVYENDLKDCSDDMIDLVPQAVIPHPEYDSESSNQQHDIALIRIEQTPPFTDFLRSICLPEQNFESSATPGKKLSVSGWGRTDIFKDNLGPDVLSPIKLKLSLPYVEREKCSKTFRPWSFALGPGQMCAGGERAKDTCAGDSGSPLMSYDMKRAIWYITGIVSLGVRGCGVEGLPGVYTNVHHYLPWIKMYTGA
The following text describes a protein:
Function:
Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Sequence:
MERSISFNPRGDNELPDDRSSDVGYAANDRRLAYSRSFQQSHGPRTPAVTEAAKPFLDRTVSSIDMPPDIYSVDGSDVFFGEGKDVDMAKVSVLEMVWEVFGVVTSGNRQMKRLFLLIALNVLYSTTELSIGIFTGRVGLVSDAFHLTFGCGLLTFSLFAMATSRKKPDHAYSYGYKRLEVLSAFTNALFLMFMSFSLAVEALHAFIQDESEHKHYLIVSAVTNLLVNLLGVWFFRNYARVNIAYRKAEDMNYHSVCLHVISDSIRSAGLILASWLLSLGVENAEVLCLGLVSVTVFMLVMPLFKATGGVLLQMAPPNIPSSALSKCLRQITSREDVTEVLQARFWEVVPGHTVGSLRLQVKSGIDERPLLQYVYDVYHDLGVQDLTLQTDYT
The following text describes a protein:
Function:
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MALRIVPCVLFGSLFSYLVNVSIVPVGGDRVHQKPRFLGVRSGSAISMFCYISLGNHTNEVQWVKTLKHDASDEVLVTESDTVKFKGSVKDNNSTITIVGVRSEHSGIYFCKYDSVKGPGSELLVYSSLKPEDALKKSKMKDAIILIQTFLLVLCILVPLLWFKYKGKSEDRDYEEPEDDHTYEGLEIEQCAMYEDIMTLRQTPETAWEQGEHPCQE
The following text describes a protein:
Function:
Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVQRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIAATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPVIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSFNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARSQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTISLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRWDDLIMVCCSLCFILSTGSFIFLWMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
The following text describes a protein:
Function:
Together with flp-18, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit; [SADPNFLRF-amide]: Inhibits the activity of dissected pharyngeal myogenic muscle system; DPNFLRF-amide: Inhibits the activity of dissected pharyngeal myogenic muscle system; [PNFMRY-amide]: Acts as a ligand for the npr-22 receptor in vitro.
Miscellaneous:
MISCELLANEOUS: [Isoform b]: Expressed at about a twofold higher level than isoform Long.
Subcellular Localization:
Secreted.
Sequence:
MTLLYQVGLLLLVAATYKVSAECCTPGATSDFCTVFSMLSTMEQNEVMNFIGENCDGDAEVALQKMEKRKPNFMRYGRSAAVKSLGKKAGSDPNFLRFGRSQPNFLRFGKASGDPNFLRFGRSDPNFLRFGKAAADPNFLRFGKRSADPNFLRFGRSFDNFDRESRKPNFLRFGK
The following text describes a protein:
Function:
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly pdi1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on pdi1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MKIAKGLVGLLILYKNVCQVLCKSGSSVKSGSPWSIKNDGKSIIHDTLNSSYSDIENLNSRVSPLLFDLTEKSDYMRFYRLNLFNKECRYNLDDNVACGSSACNVLVTDEQDVPEVWSSKSLGKLEGFMPELSRQIVETDRSVMEHVDKISQSCLLERLDDEAHQYCYVDNELDSGCVYVSLLENPERFTGYSGPHSTRIWEMIYNQCLPDSSAPTIDFPALFMQGPLAPPPKPQEQLLKERMDAWTLEQRVFYRVLSGMHSSISTHLCHGYLNQRNGVWGPNLQCFQEKVLNYPERLENLYFAYALMQRAIDKLYGHLDSLTFCHDSVLQDSEVRQKIAGLVSLIHNSPKMFDETMLFAGDPSISTALKEDFREHFKTVSALMDCVGCERCRLWGKIQTNGFGTALKILFEVSNIEDEVTNFDSRSFSLRLRRSEIVALINTFDRLSRSINFVDDFKQIYSEQHKPASFKRRVLRRIKQLLFSVTPVALHPFLQKTSSILVDLYFDFKAEWDNVMLGFRYVFASYLRFPRLFKFVLFSQESPFLNWTSHHLQRYIPKNWFPEVASV
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTDNNSKSKDSSQKIPNDSLTPTISKGLRKDVFYWTKAIAYTTWNFFDSSPVTPQRNPISLFVRGLSHPFLRHRLSKSQFNEWFLSHNGVDPVQAQTLPDPLLFDIPDHQETSYSLLEGYSVTAHDHSDTSPLPITSSNQKEGKKNVSSIDVSMVSDSSEFKPDSLQHEKLVKKCNQLRLQKLINSSELAQIDLELSKLYSRRRQVLERLSKIEEQNLKYTSKLASVEKLMLDSDAQDLYSSYSHDLIPSQIEAGKNGANPDVFDDTHDKYTDNLSARAISPRAPRPSTASEVVSDYFEQNSAFSKAPENTESSVNQNYIVGNLVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSDYVSCLAIQDSFIATGSMDTTVRLWNLDNDVLHKDNPVEESLNSPPDQPVDNATNVLTSHTAPVTALALSSDDVLITGADDKTVRQWDIVTGRCIQTLDFVWAETHDTSTSQILVSDTYKQEPFIRALDCLDAAVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQFDSNHLYSGSYDNSVRIWDLRSGSPINIIPMEKKVNSLRLYQGRLAVASDEPNVRIFDTVSNRNWICSIPSHSDSIAAEPNSVPTSVQYKDRFLVDGKSDGSVSVFSA
The following text describes a protein:
Function:
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MSEFIKPPYNFSWLVEKELACMAWPQSVYNLEFLRKEGISHLVTLSPEKIPPIVDFPQIEWTRIDIEEFEAPTLDDIIKFIEICEKCKKNGQAVGVHCRMGRGRTGVMAACYLVRFQDFAPEKAITSVRLQRTGSIETSEQERAVVRYRDYLRGTKI
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MSFRGIVQDLRDGFGSLSRRSFDFRLSSLHKGKAQGSSFREYSSSRDLLSPVIVQTSRWANLPPELLFDVIKRLEESESNWPARKHVVACASVCRSWRAMCQEIVLGPEICGKLTFPVSLKQPGPRDAMIQCFIKRDKSKLTFHLFLCLSPALLVENGKFLLSAKRTRRTTRTEYIISMDADNISRSSNSYLGKLRSNFLGTKFLVYDTQPPPNTSSSALITDRTSRSRFHSRRVSPKVPSGSYNIAQITYELNVLGTRGPRRMHCIMNSIPISSLEPGGSVPNQPEKLVPAPYSLDDSFRSNISFSKSSFDHRSLDFSSSRFSEMGISCDDNEEEASFRPLILKNKQPRWHEQLQCWCLNFRGRVTVASVKNFQLVAARQPQPQGTGAAAAPTSAPAHPEQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLSSFDTKLACE
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MTRTRKFDQDQVVKYDANVRFFSLYGTENFTRRYNLLNNSLLEYTVEPNLVANDHLVYSFTSLGPRERAPLVLVFVNNDPFLIVRSLERTIDVNHFGKITIEDRVTLENNGAALTGPYHFVPQIRGKASTGWLYTHLPASAENVEFFDDLGNCSETRVYNYGTYKTLKFKTRYPLLGGWKTTYNLRYDVPTYEYLFVLGDFFKLQMRAVDYVINDKVVENAVVRVFLPEGSRVDNVALPPQIGLMGEELGCLGSLCVYGRPIVVLNGTDLFDNYVQNLEIEYFLRPLFLLKAPILITAYLEVGFVAVLGALRYFTHL
The following text describes a protein:
Function:
Confers broad-spectrum resistance to pathogens.
Subcellular Localization:
Secreted.
Sequence:
METVTSLVFIVNLLIIFTSVVNQARGDTCIDGLGYCNNCDERCKAKHGPSSESSCDRSVGVPLCKCYYECESPPSPPAPPKKCDGGAGICSQRCQGQCCDMNCAQKYIGGHGFCNTLGTFSFCQCEYPC
The following text describes a protein:
Function:
Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MGALRSKKWKAQGKHVFITGGSQGLGLAVAELLASKGAHVTICSRTESKLRESVEKVKAAAKSNSQNIDYIAADVSTFEGAKRAIESCRVVPDTVFCCAGGAKPGFFIEQTESDFEKGIKTDYWTCLATAHASANAMARTNLADGKIVLVSSTLGLIGLVGYSQYAPMKHAIRGLAESLRSELILYGISVHAYFPGTILSPGLEEENKTKPKITLEIEGQDDGLTPAQCAKGLIKGVERGHFFITTDFNTELFRSAALGASPTNRGVLDRAVALIAWIAIPVWRNLIADRAIKKHSKQHKQSLFSAPTN
The following text describes a protein:
Function:
Involved in photoprotection. Forms a complex with LQY1 that is involved in the repair and reassembly cycle of the PSII-LHCII supercomplex under high-light conditions. May function in guiding the release of psbC from PSII core monomers.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein. Note=Found in the stroma lamellae > grana margin > grana core.
Sequence:
MEVSMSLNALTRLPLKNTGRFEEVGLARHSLFSSRTACRETAVQQRRMVFVVEAKGKKGMAARQYQRTPPPMPKIEDDGNPRFVIFIRMANVYLWYPLSIIAGGTTAKIMVAAKDNLLGKYIYKDTIARNIAAVIYRDEKEIQKTAIKQHRVLRTATEFRYGYKLVENGNMRAALSTSDVIELPTQDQLKTVFDKVKDYFGDAKESFGKLSSLNPGSDEKTEETSDEKAKA
The following text describes a protein:
Function:
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
FTPFQASLFPLLNSYADVLFANQSFNFDKDYQNLIALHSLNHIYKARDRVMKHTAKIKADIMANKQPIEYRDQGFTRPTVLIIAPFRNRAFQIIKTFFALSGCTSQENKKRFMDEFSPVPGEDEADKRKPEDYRKIFAGNIDDCFRIGIRFSKKQMKLFSPFYSSDVIVASPLGLKMIIGSEGDRKRDFDFLSSIEVVILDQAEIFMMQNWDHVKSIFTSLNLIPKNAHNCDFSRVRSYALDGRAKYVRQNLIFSSIISPEINALANTGSQNVAGRVKITRAYSGTISDVANHVPQLFHRMHQHSVQSSPDTRFTYFIEQILPTLRRSMIQKPHTLIFIPSYFDFVRVRNYLTEHNYSFGSISEYTSRSECDRVRHQFKIGDLSFLICTERFHFFRRNNLPGVRNIVFYQIPTNAIFYSELLNMLEHNAGDLTCSVIYSMYDKLALERVVGSVRAERMISSVKDTFMF
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSIPIPPHGKLYDLNIQYESNCLMETTSKANMAVRLGYEVVAINQNVSSVAKETKAKRMKLMLPEPPPLLHLDAESKSYLKINKKNFQQYSRITIELCELGDLHKVRDVLSTGLYDIIAVLPRTDRLFHSACTELHIDIICIDGSEKLPYLPKHATVQAAISRGINFEVCYAPMIRDTTMRRLTINNVQRLVESSKGKNLILSSGALHQMEMRGPYDVANLSTLFGIKENLHIHCVSNNCRSAIVHSFTRKTAKCAVYVQQLNETIATI