lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Miscellaneous:
MISCELLANEOUS: The crystal structure corresponding to PDB 1SG9 shows a glutamate anhydride cross-link formed between the Glu-97 side chains from two molecules, but this has not been observed in other PrmC structures from T.maritima. This cross-link is suggested being an artifact of concentration during crystallization.
Sequence:
MDTRKNVSGAERKIWSLIRDCSGKLEGVTETSVLEVLLIVSRVLGIRKEDLFLKDLGVSPTEEKRILELVEKRASGYPLHYILGEKEFMGLSFLVEEGVFVPRPETEELVELALELIRKYGIKTVADIGTGSGAIGVSVAKFSDAIVFATDVSSKAVEIARKNAERHGVSDRFFVRKGEFLEPFKEKFASIEMILSNPPYVKSSAHLPKDVLFEPPEALFGGEDGLDFYREFFGRYDTSGKIVLMEIGEDQVEELKKIVSDTVFLKDSAGKYRFLLLNRRSS
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is essential for activity, but not assembly, of the enzyme complex. This subunit is also required for silencing the ATPase activity of V-ATPase when V1 is detached from V0.
Miscellaneous:
MISCELLANEOUS: Present with 22500 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGATKILMDSTHFNEIRSIIRSRSVAWDALARSEELSEIDASTAKALESILVKKNIGDGLSSSNNAHSGFKVNGKTLIPLIHLLSTSDNEDCKKSVQNLIAELLSSDKYGDDTVKFFQEDPKQLEQLFDVSLKGDFQTVLISGFNVVSLLVQNGLHNVKLVEKLLKNNNLINILQNIEQMDTCYVCIRLLQELAVIPEYRDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVKITIKEKVSRLCISIILQCCSTRVKQHKKVIKQLLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQELTSFDEYVAELDSKLLCWSPPHVDNGFWSDNIDEFKKDNYKIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVVELLPESIDVLDKTGGKADIMELLNHSDSRVKYEALKATQAIIGYTFK
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence:
MLESLNRRNSIDSNQGDNDNDNDNHSNDELSPSELYYSPSGSPPKSQLLLRKSSSPSSYSPIKSDLPNIYSHLRSNDSESPPQPSPKQQSSLSSSSSSSSSSNTKSSTTKNIFKKLLRINKSSDNIDESRSIVSNNGGSPMSDSTTVTSTLSTDTAPKRGKSIQRSQILHHTDSDSLYLENQIELRPEISKSIGNIKIPSIFTNDGMPLLKISHKSKKRILFWIDPSCFKFSWRMANSTTTTTSATTSATTSGLPQGITNTTALSNSAIISTPAIATSAIHRLSITNRTTHEFVLDDIKSIYIQNEGSGYREELNISQKLEKNWITIIYFNHKKNSLKSLHLITDNDHDFKKLISAIYNLKQLRSQLAKEFLIDLNELDENYVKMLLNKELLAGDNGNVDGNEVDIQKSHKHVREFLSFNDILKYSKRLNINVNTNHLQQIFDQVLLLSSATTEKPVSTPLFEKGLNFEQFKQFVSILKDRKDLQEIWDSLAQGKEVLQFDEIKNFIINIQKENFSDDDDNSTINLIFQKYCSNDNGWNKESLNEYLLSSYSTPYREITQTQTNYYDYPLNEYFISSSHNTYLTGRQVAGDSSVEGYIRTLQRGCRCVEIDIWNGDSNTTTTTVIGTKDDDDKNEYEPIVNHGRTFTKPISFANVIRAIKKFAFIVSPWPLILSLEIHCSPECQIKVVNILKDILGENMIIAPIDIDSVILPSPAELKHKFIIKVKKTTSFQNLIETENGSFTTSTTTTTTTTTTTTTTATSLSEDNENNKSNSSSTSSFIIRRRKNKSPKIINELSNLGIYTQGIKFRNFSLPESKTFNHCFSLGEKSINRMIKDDDKKISLDKHNRRYLMRVYPSGTRLKSSNFNPLPYWSHGVQMVATNWQTYDLGQQLNEALFENKIFQGYVLKPSVLRKPTLKSSSSNVDTRTSLTTTNSKTIRFNFEIISGHQLPKFPKDDYKDQAINPYISFEIIGAQDVQWDNNDSSPIAPTTSSSPFIRTTKIIRENGFNPNFNTKFSGSIITTTNDLIFIKFVVYASTSLNYPDYGENFPIAILVTKLNYLKQGYRYIYLNDLLGEQLVYSSIFIKIEYDEDLLNEFINK
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Sequence:
MASVAELKEKHAAATASVNSLRERLRQRRETLLDTDVARYSKSQGRVPVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMACAFAPNGQSVACGGLDSACSIFNLNSQADRDGNMPVSRILTGHKGYVSSCQYVPDQETRLITSSGDQTCVLWDVTTGQRISIFGGEFPSGHTADVQSVSINSSNTNMFVSGSCDTTVRLWDIRIASRAVRTYHGHEDDVNSVKFFPDGHRFGTGSDDGTCRLFDMRTGHQLQVYSREPDRNSNELPTVTSIAFSISGRLLFAGYSNGDCYVWDTLLAEVVLNLGNLQNSHDGRISCLGMSSDGSALCTGSWDKNLKIWAFSGHRKIV
The following text describes a protein:
Function:
May be involved in 20S pre-rRNA processing.
Sequence:
MNINMEILRNFTARTLKSWSGYQLALDNSCGGDETREKDKWFLDVLCEQMTTSRGLKAEDLEEWLTNILYHDFDLILEDDSSYQIAFFLLEGFGYIKNQNEAGLQQLLSKLPSDEELAQAKRESVRGAENDEDDEDMEIPEEEEEEEQGPSEPREPQRQVVVDEDGWTTITKRQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MKQYTEEAKNENNCNVEDKLPVEIYCLCHRVPRHVIGSDDSSCNRFDWNICLDSVHFVDVELACAEAANVFFIFKKINLDIFILFSCVFLILRHVADGLSWFLIIELFISSENEDLRIQQRCPVCKAELSKETLILIFEGDQTIKTSKHKVPILGIIIPIRPFGLASGFRSLRSSFRSSTPSPTQQIYDHGYLHNLSQIYYSDQPKTTTTNMYDPVIGMFGEMIYERVFGNSITIIYSYLGSYKIAGSTGPGMRRHSLEVDKSLTRICLFLFCCGFVFFLSF
The following text describes a protein:
Function:
Not known. Putative receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNPSISTAGAVVDDFQMSCRFSNFGDHAPESFDSLSCGACFYFIFMLVEHYKDRYVASLCEDTFGVLVCPVDVSDKICNCYNREYVYNIPEFALNSSRIKPLNHLRLDPPLPFQFDLIVKDCCSAARYCCRNTLVKYHHRVDDSPCPPTWDGWNCFDSATPGVVFKQCPNYIYGGSNIKTDYDRLSQKVCRSNGWATPEVNAAAREHTDYTGCMSNGDVEARILAGLLTYSASVIFLIPAVFLLTLLRPIRCQPMFILHRHLLISCLLYGAFYLITVSLFVVNDAPLSSQVFQNHLFCRLLFSIQLRYLRLTNFTWMLAEAVYLWRLLHTAQHSEGETLRSYKVICWGVPGVITVVYIFVRSLNDDVGMCWIENSTVAWIEWMIITPSLLAMGVNLLLLGLIVYILVKKLRCDPHLERIQYRKAVRGALMLIPVFGVQQLLTIYRFRNVCLIYRLLHKSFCRRMCSEILVITSGEAGSRS
The following text describes a protein:
Function:
Leucine-rich repeat receptor-like protein kinase involved in secondary cell wall formation in xylem fibers. May play a role in a regulatory network which also incorporates the TDR/PXY signaling pathway and regulates the maturation of interfascicular fiber cells. May promote the initiation of secondary cell wall deposition during the procedure of cell expansion.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MAAKPLLLPLLLLLHLSITLAQNDTNALTLFRLQTDTHGNLAGNWTGSDACTSSWQGVSCSPSSHRVTELSLPSLSLRGPLTSLSSLDQLRLLDLHDNRLNGTVSPLTNCKNLRLVYLAGNDLSGEIPKEISFLKRMIRLDLSDNNIRGVIPREILGFTRVLTIRIQNNELTGRIPDFSQMKSLLELNVSFNELHGNVSDGVVKKFGDLSFSGNEGLCGSDPLPVCTITNDPESSNTDQIVPSNPTSIPHSPVSVREPEIHSHRGIKPGIIAAVIGGCVAVIVLVSFGFAFCCGRLDRNGERSKSGSVETGFVGGGEGKRRSSYGEGGESDATSATDRSRLVFFERRKQFELDDLLKASAEMLGKGSLGTVYKAVLDDGSTTVAVKRLKDANPCPRKEFEQYMEIIGRLKHQNVVKLRAYYYAKEEKLLVYEYLPNGSLHSLLHGNRGPGRIPLDWTTRISLMLGAARGLAKIHDEYSISKIPHGNIKSSNVLLDRNGVALIADFGLSLLLNPVHAIARLGGYRAPEQSEIKRLSQKADVYSFGVLLLEVLTGKAPSIFPSPSRPRSAASVAVEEEEEAVVDLPKWVRSVVKEEWTAEVFDPELLRYKNIEEEMVAMLHIGLACVVPQPEKRPTMAEVVKMVEEIRVEQSPVGEDFDESRNSMSPSLATTDG
The following text describes a protein:
Function:
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).
Subcellular Localization:
Cytoplasm. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.
Sequence:
MSEQERIQDCLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVSVCPCGDGTVILKAIPDESTKGIASLVAKQRRSHKVRNSMQKGRSSVCSGRVPYRGRVPPILPAVVKSELKDLLALSPVLLSDFEKAFARRFGRSFQYMQYGFLSMFEVLSAASDVICVEQTRAGSLLTLKKSASEEKQREWPAGKIFTQPFRMKQQGSYSTGFPVTKTRFSQPISNMEPPKQVLSMEKIPMFNTVEASRLSHTEKLNQLESTFKSVIAQIGPGGTVDPDLKHKIKFVVSKFPQGLFISKLLGEFELVFKEQLSPKQLGFLNVTELVGALSDILRVEFSEEKQDLLVFDADLRPLLPAGPLSSVRNSCLVQPDKRIEANAWASSPSRNSLSTVAVKKTTWDCPLKNHKEAEQKAYKKPNLVVKPLQLQVETNKSQLSLSMANHDIPPDAVRAKKLCRLPPLDTSTLVGVFVEYIISPSQFYVRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPEYFIQPGHLCCVRISEDKWWYRVIIHRILGKKEVEVFYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPAEEHWTSKAILHFQKLCGLKPLVGVVDEYIDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENAPSKGFRDFNPPALYTNSSAAPGDMVLTELGHPAQQHYLNEDGEILQQPQQDINDEKSISHLKSVSEELLKDSKLGPLKTRESCEEEPQWSILKPKDPKEENEDEVPTGMPCLESVTIGDDIWDENWLPLQAKMGKAGGPASHLFTSSLVGKKQYQTRGETTRKDWCFSTSKDIWDDSWQPLGLANDVKGRTHTPEGPIAQEKNIGTTRIRKQPDLQYPLDSSTLPKLEEFYISLIKSQQSAEGSQSEPASIQTPLKPGQASSTAPSSTPAAGDSPENHSGSAPDFSEALHSSKYSHGCLGSSCAVSHVQEPPALVPQCERREA
The following text describes a protein:
Function:
Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSRAGTWLKMLGVGIVICVGGPALVEKLRPTDAELIQRYNPELRERSMREGDRRAQEFDDYVTKLKEWSKSDKSIWFAAKEMEEKRLAEQQAIQNQTKEQARIQREEMRKELMGEK
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MAPKGTSLDEKKERLLEEMLKRGEIYSNKTIETLSKPTGISSMVIKNVLQALVNEDLVDTDKIGASTYYWCFASKRSQAARTELARLQKALEEQTNFIDKATARIEELKVGREETEERSSLLKEKLALQVKLEEQRGTFRDLLKNDPDVAQKLRNYTDIAKQEANLWTDNIFCLQKYMLTKLQMDKKTVSTALGITGEFDYLE
The following text describes a protein:
Function:
May modulate the activity of a sodium/potassium-transporting ATPase.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSQLTELVLLTVFLALFSRAEANPFVYNYEALRIGGLVFTCVLVAGAVTALCWGQCKPKRKHDDDASKI
The following text describes a protein:
Function:
Cleaves proteins, imported into the mitochondrion, to their mature size.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSARLLLLRRLLFPLRFQVGRAAPWRAVSTGWSPVGAAFNVKQQRRLDVFGKNTGLFGVPELSSPEGFQIVEDNALRNTESLVERVCSSPPSAETVRLFDQLSNELCKVADLADFVKVAHPDSSYREAAEEACRNIGTMVEKLNTNTDLCQSLRCLLGNQQVMDSLDPETRRVAELFLIDFEISGIHLDEEKRKKAVNLNVVISDLSSEFLLGANLPNRIDKQALPEHIHSQFPWDGRYIQVGGLHADSPDDLVREAAYKIFLYPNANQLECLEELLASRNSLAQLVGYPTFAHRALLGTMAKTPETVQTFLQKLSDKLHDRTLKDFEMMAGMKMKLNPVSGNLMPWDHPYYSGVLRAERYNIEPSLYSPFFSLGACMEGLSSLFHQLLGISLFCEQPEKGEVWCEDVRKLAVVHEEEGLLGYIYCDFFHRAEKPPQDCHFTIRGGRLKENGEYQLPVVVLMLNFPEYSKKSPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCATDFAEVPSILMEYFSSDYRVVNQFARHYQTGQTLSKPMVSRLCESKKVGAASDMQLQVFYAMLDQTFHGVHPLKGSTTDILKETQETFYGLPYVPQTAWHLRFSHLAGYGAKYYSYLMSRAVASMVWKQCFMKNPFDRAMGERYRREMLAHGGGKEPLLMVQGMLQKCPSVDDLVDALVSDLDPDFETFLMDSE
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MASGGGGGNCKPNSNWSKPQEKLPVHVEDALSYLDQVKIRFGSDPATYSGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLMLGFNAFLPLGYKIELPKNGKVVVQTSLASPVSSDATTSSLSSSRVIVPPVPENVLSEVPEESRQQEKEKPQPPPESDSLEFHNAISYVNKIKTRFLDRPEIYRSFLEILHTYQKDQLNPKGRPFRGMSEEEVFTEVASLFRGQEDLLSEFGQFLPEAKRSLFTGNGACDLSSRKLEYQRNLEQSRKRSRPLLLRSMPSSKKKMKMRKSKDQSMASVGKYGTLQEFSFFNKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVTPFLGKFPELFAQFKSFLGVKELSFASPVTNDRSNEGIGREIDYASCKRIGSSYRALPKSFPHPKCSGRTALCKEVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMSPEDQEKFRLDDRLGGTSEVIQRRAIYRIYGDKAPDIVESLKKNPVTAVPVVLKRLKAKEEEWREAQRGFNKIWREQYERAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDERQEQQPDGRTTTSSGPHLIYTYEDWQILEDAAALITFYVNRQPTIQKEDKDTIWQVLHQFLPELFFSSSSSSPSCQSLFAASADEGPTETVTESSVTELPERRRKTVTTEVAQEPPPPVETPHEPPPKTIDEVYSLFYTNNNWYFFLRLHHTLCSRLLKIYRQAQQQLMEYRTEKEREKRLFDGRRDRSNGPAMELRLKQPSEVELEEYYPAFLDMVRNLFIGNLDPTHYEDTLREMFTIHAYIVFTIDKLVQNITRQLHHLVSDEICLKVVELYLSEKKRGAAGGSLASQCVRAAKEASYQWKAEHCMTDENCFKMMFLQRQGQVTMTIELLDTEDVQTEDPTEVQHLANYMEQFINVDGAHSSQSEGFVLKPVLLQRNIRSFHSWQYRTMRVMKDEVKSSWKKLMGVESASNMDCRFRLNSHKMMFIINSEDYMYRWGTLSGAREVQPQVFQRHHEKFSEWHNRWLEENVSPRAAQVIQDWLTGEEDEEMVPCKTVCENSEVHGMSVTRYRVQYPRRAASP
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
METHHDVFVLVFGVLGNIVNSLIYLAPMVTIYDTFQEQTKQHYNAIPYSLSLFTASLMLYYAHLKGNEEALLLITINSIGCTMEVAYLIICYIYANFRAKTVIVRWVFLFNGATYLVILFLTSLVSPLSNRLKVVGWICATFSVGVYVTSLINPMMRTVVRTKCISMPLLISLTLSSIVWFFYGFFSHDYFIVMPNVLHFWLGVAQMILCFIYRNGGADERERVQSETGEINNENDEILETIEMQIAEAKNTNVDHQTDNDDIKKKENGSSSRVELEPCEIVHLQNNIVVVTRNGTRIVCNEIQSVAEPEIVEIPG
The following text describes a protein:
Function:
Plays an olfactory role that is not restricted to pheromone sensitivity.
Subcellular Localization:
Cell membrane.
Sequence:
MPEMVAFYSPETVIPTTSDTEPRKPLKRRTSALNTIFYYLGLEQRSGEDAKENQWIRILTFVVLFVTFITSAIGFFIMWFTNMYNNSLLEKLILSENSTAAEWWENPPVYPLLKVHVFNYTNTEDFFAGKATKLQVEDLGPYVYKETANKVDITHNGDGTISYREHRYIQYLPEESKGKPFDQVVVPNVVFLTGVSKKRSEGTWNQIAFNMAASSSGSSAFIKKPVESMLWGYEDKLLSLAKSMFGSDIVSSSFGMLMTRNGTSAENFTIFSGESSLEDLAVIKHLDGKSRLDLWHTDECDRVGGTDGSQFPPHLMDRKHPLQVFIKSLCRKFPLVYDSEVTALDGIPAWRYKIPNNVFSHPDEHMPNHCFCHLESGSCPPSGLFNITGCSMGAPIFASFPHFYTGDRKLIESIEGVNPVQEKHETYADIHPRLAFPIDGASRFQINIQVQKAAMVSGLEKFTEGQYLPVIWLEVVPGVISDDLRAMIYHSTYSANAIQMSLRVGSLAFFVLSVVLLIAKCFYSTRSTSKK
The following text describes a protein:
Function:
Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex, and confer sensitivity to physiological concentrations of phosphate and to fructose 6-phosphate.
Miscellaneous:
MISCELLANEOUS: Present with 1960 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
C-terminal 700 AA are mainly in alpha-helices and beta-sheets.
Sequence:
MALIVASLFLPYQPQFELDTSLPENSQVDSSLVNIQAMANDQQQQRALSNNISQESLVAPAPEQGVPPAISRSATRSPSAFNRASSTTNTATLDDLVSSDIFMENLTANATTSHTPTSKTMLKPRKNGSVERFFSPSSNIPTDRIASPIQHEHDSGSRIASPIQQQQQDPTTNLLKNVNKSLLVHSLLNNTSQTSLEGPNNHIVTPKSRAGNRPTSAATSLVNRTKQGSASSGSSGSSAPPSIKRITPHLTASAAKQRPLLAKQPSNLKYSELADISSSETSSQHNESDPDDLTTAPDEEYVSDLEMDDAKQDYKVPKFGGYSNKSKLKKYALLRSSQELFSRLPWSIVPSIKGNGAMKNAINTAVLENIIPHRHVKWVGTVGIPTDEIPENILANISDSLKDKYDSYPVLTDDDTFKAAYKNYCKQILWPTLHYQIPDNPNSKAFEDHSWKFYRNLNQRFADAIVKIYKKGDTIWIHDYHLMLVPQMVRDVLPFAKIGFTLHVSFPSSEVFRCLAQREKILEGLTGADFVGFQTREYARHFLQTSNRLLMADVVHDEELKYNGRVVSVRFTPVGIDAFDLQSQLKDGSVMQWRQLIRERWQGKKLIVCRDQFDRIRGIHKKLLAYEKFLVENPEYVEKSTLIQICIGSSKDVELERQIMIVVDRINSLSTNISISQPVVFLHQDLDFSQYLALSSEADLFVVSSLREGMNLTCHEFIVCSEDKNAPLLLSEFTGSASLLNDGAIIINPWDTKNFSQAILKGLEMPFDKRRPQWKKLMKDIINNDSTNWIKTSLQDIHISWQFNQEGSKIFKLNTKTLMEDYQSSKKRMFVFNIAEPPSSRMISILNDMTSKGNIVYIMNSFPKPILENLYSRVQNIGLIAENGAYVSLNGVWYNIVDQVDWRNDVAKILEDKVERLPGSYYKINESMIKFHTENAEDQDRVASVIGDAITHINTVFDHRGIHAYVYKNVVSVQQVGLSLSAAQFLFRFYNSASDPLDTSSGQITNIQTPSQQNPSDQEQQPPASPTVSMNHIDFACVSGSSSPVLEPLFKLVNDEASEGQVKAGHAIVYGDATSTYAKEHVNGLNELFTIISRIIED
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGEKKDEDKWKNLRCVNCGVEAPSLYRRFSKEIIKLTPCECCGEAVDQYVEYDIVLIVIHLVLLYLPAYTHIVHNTRYKVYPRLAFLFILCMTFDRWYQRERSGLESILDLEYGFYECFFLSIFQMGLFLIFSLLVAHFSSFNKEQLILTANSVILGYFGSVATVVCIVYGVRDTLYYRILMLVFLYASQIQVHRALFPSRSFLLTSSLVIIGKSLSLFIPSLIQ
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MYEKEAKQQEEKIEKMKAEACDDYGIKKQIPTPQSCPSTLILPRPSTLKLLLFTTEMTSTAMIEILQESRMMIPDCQRRLEVAHAELTQLLENEKELEEAEEYKEARSILESVKLEA
The following text describes a protein:
Function:
Required for polymorphic O-glycosylation of the serine-rich repeat protein Srr2. Catalyzes the second step in glycosylation of the serine-rich repeat protein in this bacteria. Transfers glucose from UDP-glucose to the terminal GlcNAc moiety of 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-[protein] which results from the first glycosylation step of Srr2; does not use other sugar nucleotides as substrates. Complements deletion of the gtf3 gene from S.parasanguinis strain FW213.
Domain:
Dimerizes via the C-terminus; dimerization is required for tetramer formation (By similarity). Binds protein substrate via an exposed loop in the N-terminus; Dimerizes via the C-terminus; dimerization is required for tetramer formation. Binds protein substrate via an exposed loop in the N-terminus.
Sequence:
MRTYITNLNGHSITSTAQIAQNMVTDIAVSLGFRELGIHSYPIDTDSPEEMSKRLDGICSGLRKNDIVIFQTPTWNTTTFDEKLFHKLKIFGVKIVIFIHDVVPLMFDGNFYLMDRTIAYYNEADVLIAPSQAMVDKLQSYGLTVKKILVQGMWDHPTNITLQAVNHKKLVHFPGNPERFNFIKNWRIPTELHVYTDHNMQLPTTVVKEPYQSDEQLIMKMSEGGYGLVWMDDRDKQYQSLYCPYKLGAYIAAGIPVIIQKGIANQDIIEKNNLGFIIEKIDDISNIVESTTEEEYMEIVSDVRRFNPLVRQGYFTRKLLTDAVFSALNSM
The following text describes a protein:
Function:
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
Subcellular Localization:
Lysosome.
Sequence:
MAASVLIKVLVSVGIFFHGCQSDVRCRNDHGVEVDWYILYKLRNTQKDGSSYLYMDENTNGWTVSNQKIDSRSGCLGWTLKPLLDFYVKQTEGFGYLLYNDQPPNPYVAPKSFGHSKGVVMLDRQTGVWLSHSTPRFPTYRSQNFWPESGNANAQAFMCITFPYAQFEAIGLQLKYIHAYSFDSHVPQVFHMELQCVAQRSCYPKKEPWFKVANLKSMGGHSFLSFAKYTRFKDDLYSGLITNTLPSNLYVKSWGKMHDSLASNCSSSIPHHVYNVKTVKLLKRDFNDTVDHSKWCVTSDENWTCVADMNRETSQMGRGGGALCMDSYEVAKAFRSTISAYEPCQTLSTASKREL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RPB4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II.
Miscellaneous:
MISCELLANEOUS: Present with 6420 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Seems to shuttle between nucleus and cytoplasm in a complex with RPB4.
Sequence:
MFFIKDLSLNITLHPSFFGPRMKQYLKTKLLEEVEGSCTGKFGYILCVLDYDNIDIQRGRILPTDGSAEFNVKYRAVVFKPFKGEVVDGTVVSCSQHGFEVQVGPMKVFVTKHLMPQDLTFNAGSNPPSYQSSEDVITIKSRIRVKIEGCISQVSSIHAIGSIKEDYLGAI
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSEALDIDNAKAKIGLVFSYWKKVANNDFSKCSVFCVLSGKSSKDENATIQEQFQMWLTGYQLTETFFVFLKNSERILILTSDKKKRFLQPLLDNIKNVDVLERSNDNTSNFENIKSTIESTNCDEIALLKDKDATGSFFENCYDFIKTLNKKEMDVNNNIKELLNFRSDTDMKIQKSGSDIACIILKSILITTIENALDNEEFESHDKIKEKALKFMDNKKCVMKLKDKLKVDIEEIDVIYSNVQSGNNFTLTYKNSNDKNYLSQNEGTILVGVGLKYKELCCNITRTLLLNARTQHKELYNFTISIEKYIIKECLKVGTNFSSVYKKTLEYVKEHKKEYKTLSNIQIENYFVKCIGHIIGIEFIDKEYLIIESNHQGKIQKNTSYNLSVGFENVQGLEKNKFAIWISDTICIDDNEDVIVLTDAISKEINTISYELEDTKSDDEEGDDDERDDDDEKDDERDDERDDEKDDDEDDEKKKKKKKKNVKSEKGVSVKKEKKNKHNNSHKYDDNDDEEDDDEDDDDDNDDDDDDNNNNNNNNGLHKDKKKTGISASILNNAASVIVSDRLRRRNKNSLAHNNEQEMEELNKRQHELKEKKINDIKIRFSKGTNDYKDLNKKNIKKLEDLKTYNDPDLLPKDLRPNIICVDNKHECILLPINGLHIPFHVSTIKNLSSNYEDNNDIFVLRINFLVPGNQGVVKGELNTFPTLQQNQMYIRELIFKSPNEKHFQMVVKQVKELIKQVKQKEVEADVNESKTSQDRLVLNKSGRRIVLRDLMTRPNIFTGRKILGTLELHMNGLRYAANSRGTTEFIDILFDDIKHAFYQPCDGQLIILIHFHLKRYIMVGKKKTLDVQFYCEAGTQIDDLDRAKARNVYDPDEMHDEMKEREQKNKLNLIFKNFVQQMQDISKIEFEIPYPELTFSGVPNKSNVEIFVTANTINHLVEWPPFILSVEDIEIASLERVHHGLRNFDMIFVFKDYTKPVKRIDVIPTEYIDTIKKWLTTIDIVYYEGKNNLQWGNILKTILSDIDSFVNSKGFDGFLGEDDDEEEETADDEDEDDEYEVDESELSAEEDSEYDDSEDESLATESDGDEEVEEDSEDEGLSWDELEERAKKDDKKRFAYKSDEDDEGYNKRKKKKKN
The following text describes a protein:
Function:
Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway.
Sequence:
MQNNEQTEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQDRKELIEMLASRPGDDYQLAREPLKLEAILARARKEGYGQNYRGWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGMHLR
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active GTP-bound form, acts redundantly with rab-6.1 (in its active GTP-bound form) to positively regulate the retrograde trafficking of cargo molecules from endosomes to the Golgi compartment. Required for the retrograde trafficking of glr-1, a subunit of AMPA-type glutamate receptors (AMPRs), out of early endosomes and into the Golgi compartment in neurons. Its role in glr-1 trafficking may partly be mediated by its interaction with lin-10 and association with components of the retromer complex such as rme-8. Together with rab-6.2, promotes the retrograde trafficking of mig-14 from endosomes to Golgi structures in the intestine. Plays a role in the epidermis to promote cuticle integrity and impermeability of the cuticle barrier to exogenous molecules. May have a role in the glycosylation of the cuticular surface. Required for seam cell division and alae formation. Required for grinder formation, which is the feeding organ that breaks down food. In contrast to rab-6.1, may play a minor role in the exocytosis of secretory vesicles (cortical granules) during the oocyte-to-embryo transition.
Subcellular Localization:
Perikaryon. Cell projection, dendrite. Golgi apparatus. Cytoplasmic vesicle. Note=Co-localizes with glr-1 at or near punctate structures in the neuron cell body and along the ventral cord dendrites. Co-localizes with lin-10 in neuronal cell bodies. Co-localizes with rme-8 in neuronal cell bodies and dendrites. Co-localizes with rab-6.1 in neuronal cell bodies and dendrites and in Golgi structures in neurons and the intestine. Co-localizes with vps-52 at Golgi structures. Co-localizes with rab-6.1 at vesicular structures throughout the oocyte cytoplasm.
Sequence:
MSDFGNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNSNSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSDKRQVTTDEGERKAKELNVMFIETSAKAGYNVKQLFRRIAGALPGIIKDDPVEPPNVVTMDPIRQRQIVTDEGSCWC