lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Plays a critical role in sperm-oolemma binding prior to plasma membrane fusion. Can mediate cell-cell fusion in cultured mammalian cells independently of its binding to IZUMO1R/JUNO.
Miscellaneous:
MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes). During the acrosome reaction, translocates to the plasma membrane.
Domain:
The extracellular domain assumes a distinct boomerang shape when not bound to IZUMO1R/JUNO (By similarity). Interaction with IZUMO1R/JUNO triggers a conformation change, so that the IZUMO1 extracellular domain assumes an upright conformation (By similarity); The cytoplasmic C-terminus region is not essential for fertilization. It is however required for protein stability.
Sequence:
MGPHFTLLLAALANCLCPGRPCIKCDQFVTDALKTFENTYLNDHLPHDIHKNVMRMVNHEVSSFGVVTSAEDSYLGAVDENTLEQATWSFLKDLKRITDSDLKGELFIKELLWMLRHQKDIFNNLARQFQKEVLCPNKCGVMSQTLIWCLKCEKQLHICRKSLDCGERHIEVHRSEDLVLDCLLSWHRASKGLTDYSFYRVWENSSETLIAKGKEPYLTKSMVGPEDAGNYRCVLDTINQGHATVIRYDVTVLPPKHSEENQPPNIITQEEHETPVHVTPQTPPGQEPESELYPELHPELYPELIPTVAQNPEKKMKTRLLILLTLGFVVLVASIIISVLHFRKVSAKLKNASDEVKPTASGSKSDQSLSQQMGLKKASQADFNSDYSGDKSEATEN
The following text describes a protein:
Function:
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
Subcellular Localization:
Nucleus.
Sequence:
MGATRDPEQPRGPSGAERGGPEPGDEGSAGQLVVTNPWNIMIKHRQVQRRGRRSQMTTSFTDPAISMDLLRAVLQPSINEEIQTVFNKYMKFFQKAAFNVRDNVGEDVDAEQLIQEACRSCLEQAKLLFSDGEKAIPRLTHELPGMKRGRQADEECAHRGSPIPKKRKGRPPGHILSNDRSTSGMVWKPKSCEPIRREGPKWDPARLNESTTFVLGSRANKALGMGGTRGRIYIKHPHLFKYAADPQDKHWLAEQHHMRATGGKMAYLLIEEDIRDLAASDDYRGCLDLKMEELKPFVPPSWMAEKMRKYMETLRTENEHRPSEVPPET
The following text describes a protein:
Function:
Transcription factor. Represses expression of genes involved in differentiation of touch receptor neurons (TRN), probably acting as a heterodimer with egl-44, perhaps by occupying similar cis-regulatory elements as an unc-86/mec-3 heterodimer. Plays a role in cell fate specification of neurons, including the hook neuron HOB, the gas-sensing neuron BAG and touch receptor neurons. Plays a role in neuron differentiation by repressing the expression of zag-1 in FLP neurons, probably acting as a heterodimer with egl-44; because zag-1 represses expression of egl-46 and egl-44, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates. Acts downstream of egl-44 to prevent touch cell differentiation in FLP neurons. Involved in male mating behavior, acting in concert with egl-44, via modulation of expression of polycystins lov-1 and pkd-2, homeodomain protein ceh-26, and neuropeptide-like protein nlp-8. Modulates the expression of a subset of terminal differentiation genes involved in O(2)- and CO(2)-sensing, acting in parallel to ets-5 and egl-13. May act upstream of RFX transcription factor daf-19 to regulate gene expression specifically in the HOB neuron. Plays a role in specifying commissural dendrites of the PVD nociceptive neurons, acting in concert with egl-44. In association with egl-44, regulates cell cycle exit in the neuronal Q cell lineage.
Subcellular Localization:
Nucleus. Note=Localized to nucleus during interphase and evenly distributed in the cytoplasm of dividing Q.a and Q.p neuroblasts.
Sequence:
MVPMNDFWVKAILSSTNPSPVPSTTSTVSNDENLDKTLDFDCSTQTVFPTLPMFWNPTLVQQMLALYQIQQQQIQFSAKLAPQPLFQEPTIQKEFLPFPHQSRKRPLPIDPKKTKLRKLNEDTVTSSPVSGMFIKEEADVKSVEELQKEADLLDETAAYVEVTEESRQKIDEIPNVIGDCICRLCKVKYEDVFKLAQHKCPRIAHEEYKCPDCDKVFSCPANLASHRRWHKPRNELGGSPPAQSSTIVSCSTCFNSFPTKKMLKLHSSTCQRSPLQDLLSRVIPTM
The following text describes a protein:
Function:
May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MGAIGCRRAGGPVGWQYVFEDEEDEREDEDAPLVEEEGADEDWGVEMERRGTKRKGPRSSRPRKRRRVATLCPSPASSDSGSPSSSAVPKRRRVAKLCASPASSDSGSPSWSAVPKRRRSGNGAKRGRPVAVPAETAAPAPEEATPSTSTAGRAKGRRSCHQCKAAMKQQMTKCKRCREKIYCGPCIEDMYPELSLAEVRVRCPSCRGICNCKRCTAKEQGEPKSSVLRKRNGSRSVTKRKKTNTSGVKSTRVRNEVAQTEANDNSFLSSNEINSTSVILDKVDTLDARADEIARETKVKHARYLLHYLVPCLSDLNRDQMVERKMEAKIQGLELSELSVEQADCRNDERMFCDNCRTSIFDLHRSCPNCSYELCIACCKELRENNLKGSCREELVSYPHRGIDYMHGGDPSPELMNCVQTDLSSCQPKTTKWCANTDGTINCPPPELGGCGDHALKLRQMFPKDWLNKLESDALQLSKQLEPSDIVSGYTNECPCCTKHENARHAATRDNSTDNCLYCPKSDNEKTDDLTHFQSHWVKGEPVIVQGVLQKMPHLSWEPPHMWSEVHGASTTPDMKNVKCIDCLSCCEVEIRTQDFFNGYYYGRVYQNEWPEMLKLKDWPTSNHFEELLPSHGVEYINSLPFQPYTNLKSGLLSVSALLPDDILKIDMGPKSYIAYGYAQELGRGDSVTKLHCDISDAVNVLMHTAKVAPSEGQENAIKNLKARHELQDEKDCCGNFAIDGSDACHKNCLDSNHTSSPNCSMDDDGGALWDIFRREDVPKLETYLRKHSKEFRHIYCSPVEKTFNPLHDETFYLTEEHKRRLKEEHGIEPWTFVQKLGEAVFIPAGCPHQVRNLKSCTKIAIDFVSPENVQECVKLTQQFRVLPKNHRAKEDKLEITVERTCTFGDHRQDDYDKAGRLRQREPRARLLVDAAVPAEVGHKAYHGVATKAKQTDADSHT
The following text describes a protein:
Function:
Involved in morphogenesis and proliferation of peroxisomes and mitochondria, independently from the previously defined pathway controlled by the FIS1-DRP3 complex.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MADVEDRAAKGISDYDQGGVKTTELERKIEDMENKNQELTRENRELKERLERLTGEIEEMKDVEAEMNQRFGEMEKEIEEYEEEKKALEAISTRAVELETEVSNLHDDLITSLNGVDKTAEEVAELKKALAEIVEKLEGCEKEAEGLRKDRAEVEKRVRDLERKIGVLEVREMEEKSKKLRSEEEMREIDDEKKREIEELQKTVIVLNLELVKNVEELKKWKSKKKLTEEALSETQKREKELELKKDELLKKVEEGNKTVFALNERTMKPSNGVRDTNGGDQKGSLEAEYQWPVVAAGSVGAAGLVAATFFVCYSKLR
The following text describes a protein:
Function:
Probable chaperone.
Miscellaneous:
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MLHHKFVYPFLFKWHLSCVEKCPPQITFIAKYATANDKNGNRKLTIRDEQWPELADPTPYDIFGIPKAGSGNPKLDKKSLKKKYHRYVKLYHPDHSDNIQIFSSEKVTNSDSKSPLLLTSSEKLHRFKVISQAYDILCDPKKKIVYDTTRQGWTTSYSPRSNVNTENYQYAGSYGYHSNAQYEYWNAGTWEDANSMKNERIQENINPWTVIGIICGLAICIEGTALLAKIQESLSKAEFTHDESGLHLIQSYTNYGLDTDKFSRLRRFLWFRTWGLYKSKEDLDREAKINEEMIRKLKAAK
The following text describes a protein:
Function:
May participate in the recruitment of inflammatory cells by injured or infected tissue.
Subcellular Localization:
Secreted.
Sequence:
MSFQLRSSARIPSRSCSSFTLLAFLLLFTLPQHRAQAAPFSAMVATELRCVCLTLAPRINPKMIANLEVIPAGPHCPKVEVIAKLKNQKDNVCLDPQAPLIKKVIQKILGSENKKTKRNALALVRSASTQ
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MEEISGDTTKNSMASLGILCEKDIEEQRLQIDSFIASPFQRSMESVLDRAKATAQSQVELANVKADLREAEAELVKVLGVKTRKEAKQMGLRDSISATQSRIQLLKRSLQLHKSNKEEHSKTISHRLQGLSVSKDNAGSKLTGNKSNIDEAISWYNHALGFHVEAGHGVKFTFTNIDAKRPTHEFSFTVHYGNDIYTLLDCNPQLDDMDEMVQELNTTNDLFGFVRLMRDKFQKPTLSELPAHSENLPQETSIIYASAPAMSITTDTSMLTPENKVSKVQVNRRQKRSSNSPLQSPAPTSSTRCSSRLKIGSSSYQRASSSTFHHALASPLRRLIAKDSFFQEGT
The following text describes a protein:
Function:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination.
Subcellular Localization:
Chromosome. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis.
Sequence:
MEGKSASCPEGVVSWYIRTSRLAVALAIIKLRPPGGARQFTESLAERLKRQDESWKSKAEGLHEDLLHLRQELLLTRTLLNTRSSAGQAPGQEIAKVLSQDDTREVNSGTLQTCLPPTPPNSQKVPPKDRQWRQDHRLTKHVQFLQRLSGLRSGFEESLCQDGDVVWDSVVQLLDCVVEDFRQAHTGQPLRHPEQLHNAIQVVAQTLSPGGARQGFPVQHFSRVEDLLKEMVNLLLTNQQLNAFSVQDSLSDCLLALGGNCCITRTPLIQLLMSQIIQLAQQLRDACEKSREEHEHHQVDWVCYQNSFYLFWLLERLAQDTDNRVNQELVVRLETKAFPLADEFSLFSLYMWRIGGLFRAGDS
The following text describes a protein:
Function:
Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme.
Sequence:
MLKRSIMTLYSGPLDIYSHQVRIVLAEKGVTVDIHNVDANHPSEDLIELNPYATLPTLVDRDLVLFESRVIMEYLDERFPHPPLLPVYPVARSRCRLLMYRIERNFYHSMKIIEEGTPKQAETEREFLTKELIELDPVFGEKTYFMNDDFTLVDCVMAPLLWRLPHLGVHVPPRAAKSMYKYKKLIFERESFKASLSESESELREVDGI
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCATGDSCTCASSCKCKECKCTSCKKSCCSCCPAGCTKCAQGCICKGASDKCSCCA
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
Subcellular Localization:
Peroxisome.
Sequence:
MSGPSSWRRAATVMLAAGWTHSSPAGFRLLLLQRSQNQRFIPGAHVFPGGVLDAADSSPDWVRLFAPRHTPPRFGLGPEPPRQPPFPGLSHGDADPAALPDDVALRICAIRETFEEAGVLLLRPRDADPASQEPSQALSPPAGLAEWRSRVRSDPRCFLQLCAHLDCTPDIWALHDWGGWLTPYGRITRRFDTTFLLCCLRDTPRVEPDLAEVVGYQWLSPSEATECFLSKEIWLAPPQFYEIRRLDNFASLSALYRFCSDRPLEGGEKWLPIILLTSDGTIHLLPGDELYVKDSDFLEKNMSTDKKTEEIVKEGKVLNRVVIHSPYVYEIYMTLPSENKHVYPRNYVVNKRCTAHL
The following text describes a protein:
Function:
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MAHMQNLAGGLEKVVGCLEAVSNASDMHCGYGDSAPKAGTAPYVQAFDSLLAGSGAEYLKLSKETGGDGQERAEMAHTGLKLEQALSVTASQCQQPAGNKLSDLLAPISEQIQEVIGFQEKNRGSKLFNHLSAVSQSIQALGWVAMAPKPGPYVKEMNDAAMFHTNRVLKEYKDVNKKHVDWVKAHLSIWTELQAYAKDGLPSGPSAGPGPSPPSPGPPPPQVPPSSGSDESASWSALFAQMNQGESITHALKHVSDDMKTHKNPVMGKVPTISINKTDGCRVYLSENSLDCEIVSAKSSEMNVLIPTEGGGYNESPVPEQFKTLWNGEELVSTKHSCLPSLKYTSG
The following text describes a protein:
Function:
ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. Also aids the recombinational repair of camptothecin-induced collapsed replication forks.
Subcellular Localization:
Nucleus.
Sequence:
METKSSYLKFLNEEQRISVQSPHKYTQILAGPGSGKTRVLTARVAYLLQKNHIAAEDLIIATFTNKAANEIKLRIEAILGNSEASKLISGTFHSIAYKYLVKYGKHIGLSSNWLIADRNDTQAIMKRLLDSLKKAKNPIASGIRGQELTPQNALNRITKLKSNGLLVKPGMDQLSLINGLEEPPKELQSHQSVELYRLYQTSLWKNNLADFDDLLLNFILLLQKQPDCVRNIKHILIDEFQDTSKIQYFLVKLLALQNSDITIVGDPDQSIYGFRSAEIRNLNQMSEDFEGTQVLHLERNYRSAKPILELALSIISQDKSRPKKGLKSNHISSLKPHYRLFETNNKESYWIAREIKRIVGSCPELIFYNDIAILVRSSSLTRSLEHALSELGVPYRMVGVNKFFDREEIRDLIAYLRVLANKDSTSLIRVINVPPRNIGKTKIDRIIFESERRGLTFWQTLNEVKNENILLSQRNDKSFLKSLKSFLCSISKLENRYLSNGHSATLSDLLLGILSEIKYYEYLVRKNKETVEEKWENVMELVQQSDNISCIFYELDYKISTIVLLQNFLTQIALVNEEQKEGESQKVTISTLHAAKGLEWPVVFLPCLCENIIPHSRSDDLDEERRLLYVGATRAQALLYLSSFKSVTGMFADMQNSDNVQDVSPFLKGEEMKRWVMESEIVFNEKIASEIGTILGRKSYGKITNLSGIGSNANHNGTKFENLGFQCCRVLAEAELKKRERVKSVNDYNKDETNFRKHNAKRSKTDIRSWFEKKQPIDSDVEISEPSRSASIMVANKDLNDRSFETVNRIVSTRASTTNASFMSSVRQNLGRGPSTKDQVINRTLREGHQDVVQHTDLNQSNTKVASARPAGSRKRLGVRLRVSRML
The following text describes a protein:
Function:
Oxidoreductase that promotes the persistence of M.tuberculosis in host macrophages by reprogramming the fatty acid metabolism in host mitochondria. When localized in the host mitochondria, it potentially acts on unknown lipid substrates and converts them into products that directly or indirectly alter the lipid profile of the mitochondria. This change in lipid profile results in increased mitochondrial membrane fluidity, enhanced endogenous fatty acid oxidation and increased mitochondrial spare respiratory capacity. All these events eventually favor M.tuberculosis persistence in the host macrophages. In vitro, can catalyze the NADPH-dependent reduction of palmitoyl-CoA (hexadecanoyl-CoA).
Subcellular Localization:
Host mitochondrion. Note=The localization to mitochondria is independent of the predicted mitochondrial targeting sequence (MTS) but depends on specific arginine residues at the N- and C-terminal regions. Rv0547c is not secreted by classical pathways and localization to mitochondria might occur during infection conditions by its release through extracellular vesicles or shedding by an unknown mechanism.
Domain:
The N-terminal region contains a predicted mitochondrial targeting sequence (MTS), but this does not appear to be required for mitochondrial localization as deletion of the MTS has no impact on localization.
Sequence:
MSKRPLRWLTEQITLAGMRPPISPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGLHRAVVVAVARRKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGIDILINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAALSAVSRIIETEWGSQGVHSTTLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSIGPRWVNALMQRRNEQLNP
The following text describes a protein:
Function:
Involved in the biosynthesis of K-antigen capsules. Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P).
Sequence:
MSERHLPDDQSSTIDPYLITSVRQTLAEQSAALQNLSKQLDSGQYQRVLNLIMNCKGHVILSGMGKSGHVGRKISATLASTGTPSFFIHPAEAFHGDLGMITPYDLLILISASGETDEILKLVPSLKNFGNRIIAITNNGNSTLAKNADAVLELHMANETCPNNLAPTTSTTLTMAIGDALAIAMIHQRKFMPNDFARYHPGGSLGRRLLTRVADVMQHDVPAVQLDASFKTVIQRITSGCQGMVMVEDAEGGLAGIITDGDLRRFMEKEGSLTSATAAQMMTREPLTLPEDTMIIEAEEKMQKHRVSTLLVTNKANKVTGLVRIFD
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSTSEAQTPTSIFSPSTILQDLISGLVVFLVALPLCLGIALASGADLFSGLLAGIVGGLVVAAISGSHTSVSGPAAGLTAIVAAQIASLGSFEAFLLAVLIAGVIQIIFGIARGGALSAFFPSSVIKGLLVAIGVILILKQIPHIFGHDTDPEGEMSFIQPDQENTFSELLTIFAGEIHIGAMVIGFLSIAILLVWERIPALKKSLVPAPLIVVVVGVLLNLGFTNMGQDWLVSESHLVQIPIAQSFSEFFGFLRLPDFSRTFDPAIYIAAVTIAVVASLETLLNLEAVDKLDKAKRNSPPSRELIAQGCGNMVCGLIGGLPVTSVVVRGSVNVASGSKTKMSAIFHGGLLLVSVAFLPTLMNKIPLSALAAILLVTGFKLASPAIFKQMWKEGRYQFTPFIITVIAIVVTDLLIGILIGLAISVLFILNSNLRRPIRRIVETQVDGDVTHIELSNQVSFLNRAALDRVLNESQPGGKLVIDASGSDYIDPDVLSLIRDFKQNVAPARNISVNLKGFRRKYQLSDSKQFADFTSRELQEKVTSDQVIKILHDGNQRFTSGTRLNRDLGQQVNATAAGQNPLAAILSCIDSRVPTELVFDLGVGDIFSVRVAGNIVGTKSLGSLEYAVGVAGVKLVAVLGHTRCGAVTSSVNLVAANQGAEAATGCQHLQPIVDEIAPCIPSDVTRAIENLSEEAMEQYVDKVAEDNVMHTVDEIVKRSRIIREAVEAGRVKVIGALYDVKSGHTKFLGDSVSGVIPDSSSGQTAEVAG
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.
Sequence:
MAAPTEFNAETPPLSALSAATAVTVLANPNRKVFTGKSGPRTTSQVPTEISQDPELLEALRCLPSNYNFEVAKTIWRIRQLQARRVALQFPEGLLIFAFPIADILEKFTDCDDVVILGDVTYGACCIDDFTARALGADLMVPTEISQDPELLEALRCLPSNYNFEVAKTIWRIRQLQARRVALQFPEGLLIFAFPIADILEKFTDCDDVVILGDVTYGACCIDDFTARALGADLMVHYGHSCLIPVDQMNGLKMLYIFVDIKIDVLHLIDTVKLNWTTETSLALVSTIQFVATIQAVATELRAAGYVAKVPQIRPLSPGEILGCTAPKVDDVDLVIYVGDGRFHLEAIMIANPTLKAYRYNPYDKTLTEETYDHAQMLRVRRTAIQKASTAGTNDNLERNVVSVLLSEVFPKKLSLFADVDAWVQTSCPRLSIDWGLAFEKPVLTPYEANVALRSVAWQDRYPMDYYARDSLGPWTPNHKPPAAEVPRKKCPDCSCGTSS
The following text describes a protein:
Function:
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Membrane.
Sequence:
LLRRMGREASESVPPGAAASTPAMPRHDPEVIIVGSGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGELLQPGGYRALKDLGLEDTVEGLDAHVVNGYIIHDGGSNSEVEIPYPLSPDSQVQSGRAFHHGRFIMGLRKAAMAEPNTKFIEGVVLQLLEEDDTVIGVQYRDKETGDIQELHAPLTVVADGLFSKFRKNLVSNQVFVASHFVGCIMKDAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLRDYMVERIYPQLPGKIYYLETFDFFPFCLGVLLLGDAYNMRHPLTGGGMSVVLNDIKIWRGLLKGIPDLYEDAAILQVRRPKKSHSFVVNVLAQALYELFAATDDSLHQLRKACFLYFKLGGQCVAGPVGLLSVLTPNPLALVGHFFAVSLYAVYFCFKSEPWITKPRAFFSSGAILYRACGVLFPLIYSEMKYLIH
The following text describes a protein:
Function:
Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Peroxisome.
Sequence:
MIPIRMSSSHTTPGAHVKSLDSRPLYRHQASLPKLPVPTIDETTARYLKTVRPLLNDQEYQQTESAVADFKKPGGVGHVLQERLVARDQACTTSWLIDWWNDYAYMSYRDPVVLNVNYFFAFKDDKLRKNPAARAASIITGVLAFRSQLVRSQLKPDMARDTPLCSHQYRYMFNSTRIAELNTDTTRLSDPISNTHIAVMRNNQFFIIETTHANGSQLSTIDLQNQIQKVYDMAGTTKDTPIGALTTENRDVWASARKNLLAVSQTNKDSLEAIETASFVICLDNTKPVTREEVSRACWHGDGCNRFFDKSLQFIIFDNGKAGFNGEHSMMDATPTSRCCEFVCKGLDQGTIDLGYNVPSLSLPEPKKLKFDLTPALVQTIEIAKQKFDKQTALHDLRVVVFESYGKNLVKKFQVSPDAYAQMAIQLAYYKMYGVCKATYESAQTKKYAYGRTETCRSVSIESVAWVKAMEDPLVPISVKGEMGRKAIASQSSYMAAAVEGRGVDRHLLGLRFLIKADEPKPALFTDPAYAMSCHWNLSTSQITSEYYDGYGWGQVVSDGYGIAYQVKNNAFHFNLVSLHLNNEHLHTYLIEALHEMRTVFEATAPIPKAKL
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Subcellular Localization:
Endomembrane system.
Sequence:
MGFNLIGSSIFAMIFIIGVTEATNYTVGDSFGWSVPSNKSFYTDWASTKKFFVGDNLIFNWNGNHSIKITMKTIDYESCNSSWFDALTYLVTKNGTAMSIHTIDAPIGYRYFYCIVGNHCELGQKFSINVQSHSGSSPAPAPAPSFGILSAFLSSLAVYFFTLTRVLVDLEDNLKI
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYFDWNDRLPNSLRAGFQPPSEEAEEDMKRRHHAELVEYERFATSIRSEYTKPIDKSRAVQQLSRLKQQMRDRHVSEEAVLSGSERASKKAQILLNAGPSHPVASGKTDNVAEDPVRAGFLPPQDARGLIGGALAHANRMAEQASHKVLRSTVNRTAMDNEIIERYVKKTEARSGPGARFGFIQRINQKAAALGKRVITVEADNHCLYNSLIAGLHGPSENSGEAVRHLRNLVGDYIAAHADIYADMINVMVQMSLAAYVEGVKTEAMGDELECSVAAKVLRVRIHLLTPDDDVRIFDPEGSSEADIWIAYYPSYTILGDPHYNVLR
The following text describes a protein:
Function:
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Subcellular Localization:
Secreted.
Sequence:
MWLQNLLLLGTVVCSISAPTRPPSPVTRPWQHVDAIKEALSLLNNSNDTAAVMNETVDVVCEMFDPQEPTCVQTRLNLYKQGLRGSLTRLKSPLTLLAKHYEQHCPLTEETSCETQSITFKSFKDSLNKFLFTIPFDCWGPVKK
The following text describes a protein:
Function:
Antimicrobial peptides 2b, 2c and 2d have antibacterial and antifungal activity against a range of species.
Subcellular Localization:
Secreted.
Sequence:
MAINTSNLCSLLFLLSLFLLSTTVSLAESEFDRQEYEECKRQCMQLETSGQMRRCVSQCDKRFEEDIDWSKYDNQEDPQTECQQCQRRCRQQESGPRQQQYCQRRCKEICEEEEEYNRQRDPQQQYEQCQKHCQRRETEPRHMQTCQQRCERRYEKEKRKQQKRYEEQQREDEEKYEERMKEEDNKRDPQQREYEDCRRRCEQQEPRQQHQCQLRCREQQRQHGRGGDMMNPQRGGSGRYEEGEEEQSDNPYYFDERSLSTRFRTEEGHISVLENFYGRSKLLRALKNYRLVLLEANPNAFVLPTHLDADAILLVIGGRGALKMIHHDNRESYNLECGDVIRIPAGTTFYLINRDNNERLHIAKFLQTISTPGQYKEFFPAGGQNPEPYLSTFSKEILEAALNTQTEKLRGVFGQQREGVIIRASQEQIRELTRDDSESRHWHIRRGGESSRGPYNLFNKRPLYSNKYGQAYEVKPEDYRQLQDMDLSVFIANVTQGSMMGPFFNTRSTKVVVVASGEADVEMACPHLSGRHGGRGGGKRHEEEEDVHYEQVRARLSKREAIVVLAGHPVVFVSSGNENLLLFAFGINAQNNHENFLAGRERNVLQQIEPQAMELAFAAPRKEVEESFNSQDQSIFFPGPRQHQQQSPRSTKQQQPLVSILDFVGF
The following text describes a protein:
Function:
May be involved in the trafficking of signaling proteins to the cilia.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MGHIKKGELTQEEKELLEVIGKGTVQEAGRLLSSKNVHVNCLDENGMTPLMHAAYKGKLEMCKLLLRHGADASCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVAIINNFFPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVMLVSENPLLADAAALGKCYRVMDLICEKCMKQRDMNEVLAMKMHYISCIFQKCITFLKEGENKLDTLIRSLLKGRASDGFPVYQEKIIRESIRKFPYCEATLLQQLVRSIAPVEIGSDPTAFSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSVCKMVIYCDQTCQKTHWFAHKKMCKSLKDVYEKQQIEAAKHKRQEEKNGNPNVSSNHVNEDQPEAEEGITQENSIPSDSVEGEKEAANDTGLASAQDAPTGPQLSEE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MDVLLREVNEEAMADHSEENVPLLSANASAVVDHPMEEDLDDNGEQDEEEEEESSHRSISGTTVNCRVCDAVIQLEGRSLQHVVKCGACQEATPIRPAPPGKKYVRCPCNCLLICKASSTRIACPRQNCRRVITLGQVGERSSSPGTAMQAPTGTCRVACAYCEDIFMFNTLSNALATCPHCRKESAVGGSYRRSRLIYFTSGLTLSLIFAFVFTALAFLTNAGTILETFFIISLTVLYALGAYCTFKALKFYLARISTIVAPV
The following text describes a protein:
Function:
Transcription factor involved in early neurogenesis; sensillum basiconica formation and maybe sensillum trichodea development. Promotes multiple dendritic (MD) neuron formation. Required for olfactory sensilla; regulated by lozenge (lz).
Subcellular Localization:
Nucleus.
Sequence:
MLTNNELMEQFYFPDEAPAIPEFLSNDTFQQLEQLMYQQEFSTSDSQSDGANSCSLEMYYDTPSVLELEHMLNAQEQQQHHLQANPLGKNQGRSPRYWNKQQRSKPYDKLSTSMSSSTSSASSSSSSSAGFGGEVLKKRRLAANARERRRMNSLNDAFDKLRDVVPSLGHDRRLSKYETLQMAQAYIGDLVTLLSRDY
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASFGVSALDANAAGAAAAPASALTVGDQVAFGKPAASSTALTAVGIVGNITAVLVLAIPYFIFVKPVRKAKSVGAWKPYGFVMMLTNCMFWILFALPAFKHSLLVLGVNAAGVVIQGVYIAVYLWYAPAPSRRTTVKLLLGVLAICTVLAVLVIWFVMVKKVWSIRFMGVIASSFTTLMFVVGLVADMMELEEGRAGQIVFQLVVNMMNAAIWTSFGFLSAPANAFVVVPNVLGVACTAVDMAARLIYSKLTTSPAARAA
The following text describes a protein:
Function:
Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSPFPRRRCLPGDFSPSVDSRPCSSPCELPGPTGKLFLGGTPPRALRLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYHGVPVAIKQVSRCTKNRLASQRSFWAELNIARLRHANIVRVVAASTRTPAAFDSLGSIIMEFGGNVTLHQVIYGATGCPEEDGPPCSAGEQLNLEKCLKYSLDVVSGLLFLHSQGIVHLDLKPANILISEQDVCKISDFGCSERLEDLRFRPRHHLGGTYTHRAPELLKGEPVTPKADIYSFAITLWQMTTRQVPYSGERQHVLYAVVAYNLRPSLSAAVFTESVPGKKLEDIIQCGWTAPAQQRPSAQLLLLDLRALQAELG
The following text describes a protein:
Function:
Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMGSVVPLSSPAWDLNLSAGQNLLGHGSPTPSHSRKRRLSVTPEAGDSHMEHESPSKPRQQSPFVHKRARVTRQLQSRPLPMSRLLSSLDQKTLVSLLEGICAQDDRVARQVMEVTPKPTVSSAMDVLSRALDQAFALFPYKGDHQNDYAFFRVRPALEEFLAELSDYLSHFLPPNETQVSNSFAFLDQATSLVHRMPQWSSPANNRLKEETYEHIDVAWTLVCEEAAKRQRGSLAMSGVGNWLIRLEKHNELSGDRLKTSLHLLRDMLDDQGYRPPNPFASFNGAQQLFTV
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Miscellaneous:
MISCELLANEOUS: Present with 4420 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTKSRKQKQKKQDFLRKKLKVGKPKEKARNATDTSFVSKTISIRNQHLDQNPHDLTKRLTLLKHHNINVRKETLTTFQKSIPSIIKSRLMTPLLTQSIPLICDESQQVRQGLIDLVDEIGSHDAEILKLHCNIFVLYINMAMTHIVTQIQADSTKFLSHLLKYCGDEVVRKSWVKLLNGVFGVLGWGQVGKNDSASIVQTKKRNAKYVTIHLNALYTLVEYGCQDERARSDGDTAETTEDSGTLRNPYLIPDYPQPFEHLKLFTRELKVQDATSSGVNATLLSLATQDIDTRKAVFIEQFLPIVRKKIEVIIKEGGECGKSANKLKTLLAKIFD