lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MYPGWGRYGGSSSISAPAGPPSAPATGAFQSFRDQHMAQLQQLQKMHQQQLETVLPVGSTSQPAGFPPPPGAYQPHTGGYAKRSYYGPGESYPFPPPPFVSSLPPPGYPSYPPPQHHQTNPPLPEPAPPPEPAPPPEPAPPPEPDQPPPPEPAQQPPPEPARPPLPDPEKRLQPAESSSPKDSEGIRGSDGLSLEQQQHYWYTQHLMSLQQKAKLRQKENSGTYSVKSTVPQRVPVPPESELPPAPVVKEPPPPLPADDVKPSFNPPEDPEQAERLKTLQEAAAHWQQHEEHRLGFQYQGIMQKHSTLQQLLQRYQQISQQPPHIGALTVDMQLQHYEMQQKQFNPFYQEWETQFKKWQELLQTYPHKDQLQNYDVQWKSWQTQIKATKSFLKEKVNSLKSMQQQYGGNHYIGGVPVMPPYPAYPQVMPPPVPPSLPGAVNIPPPFTASAPPPFSAAMPPLPAIPAPPFSEGQPPLPPLTAAPPPLPPVTAAPPTEAPPPPPPPLLSTESQPPLPPVTTACTQAPPLPPTPLTIPVAGTQNTSVVPSHFATSKCDPGQPPLPSSGINSSVAGSISLTSGTIVSKLPLSKTTLGGTSFPSSSEKSITPDASSPVKQATDTVKLPFAESKMESESPRFWSQEKQVKPNDGFDQSINSTERSQMPFSEKASNVSRPPYQMMTRFTPQSHIFPPPRSQIHEPRGAIDVSGAPSAFEGEAIDGGTSVQGSSGHNRHTTNTIPNPDLPWEKGQDPVSEAAAGLTTSDFHQRTKNVPLGTLQSFSEREKHNMPSLKKGLDPFLSRPLEKELVESERDREKCNQADSTPVGHPQKLDPSEYHQSLGRPNQLPPDRWERAIDKSDKMWENQTSSPHGQWLGTEGQSKEKWGRLNPAPSGRWVAPVDAPAMGKWAESEGPPKIIPEAHSNLWKRSEGPTRDMHHVPSDPPCDILDDPKDPLCDSMTGHANDRWVGPEEPLNDRWSRPEGPLGDRWGRPERPPGDRWGRPGEQCIGRWGKPVAESGRCSRPEGHPEDSWTTGGGQMGEKWGVPEGSVRERWGREEEAYNERWRRLEEPTVERCSRLEEPGERWRGPEKPHEDRWERENVLSGDMWGKSKMPLGKPELNADERLKSKTGPLKGRWDGPHASLEPRWEDNSDQNIPGNKDQAGVKNIPGNKDQAGVKTGPTEAKRAADTPTISYQSKFRKNAQIGGISKGSAHSMVSNNQTRDKGNTSELDQSSEMGGTGTLANKGSESVQNDCKMGGLTAFPAMKRHDSVAKFEVTVASGVSSSLVQAKADNPVQTSPEPGAVKTDTSQVLSDVRSDKSAPSGFAKPNSSLPCLEPKPDTAPVHCPNVDTAPSLNVGNAMTSPITTKDGNLPGSDPSKKADILSPSLAKEVSESVPDSQKQSTFNAPGVGVGAPMLSNELSLKNLASEPLISEAPNQHRPSAPLVPVQPRPSAPLAPVQLRTGAPPAPGQPRFGAPPAPGQPRAGAPPAPGQPRAGAPPAPGQPRAGAPPAPGQPRAGAPPAPGQPRAGAPPAPGQPRASGTTVHGHPRPGVPHPLPRTGAPSPFRSRTPLGQGPRMGMPGPFRPGAPGPFRAGAPPVGLPRGGFPVSFRAGAPGPPRITGPRGPSSINPTELQDFQIASLPAGQIPGGSLVPQEFDHPLNVKEASKSSSAMQNILAEDPDMSLSSVRVPCSEEGESGANILRDAVPDFPERHTRHGDIENYDAIQEPAYANAHLQPGPSRLHHGRGGLREQWLQGTEQWSSQGKRLENYEVKFDQRGRGRSRGLVRERILPRPGSRDAIEHLRERDFGSRGNFLDERPPQGPDYDPLFMREMLHRDHRFSDDERPPLDPLEITIREYLDKVRLDNWEWERYMRENEFLREQSHAFLRDERLPFHHHPPLPPPPLPRDTDVRQDPWWDRLPEREQYRGPGDVVERFERPYEGHDRERDYLRVQEDLDFLTRERISAHPVRRPLSPHRSLSPLRPRSPLPPLPPLDRYLDESWRDDRETDRDFRERGDIRILEYPERQEERSREFPPKRVEWREDPWYPSENRLENRIDPSHNLETPVSLENPVPGAESSQEMESAPSSAGVLALSQRQHEIILKAAQELKMLREQKEQLDNLKNFFSDSQTSGESKHQPPLPGDSGSAPNMFKGLKSEREKSVVSEPIVKMASSTSLTTGPVPPRPMSDCWNEDTFSGLWDDERRFRSPGSLVDSGKPGSLAHGPKQPVPQQTVDYAHGRDSSVGKVEQVPYGERVVLLPDSVIERAPLPFHKDYQVDRYDRDLRDREPYFERQSNKNSDRRDYERERDRERDSHRDRSFGEHERERFDRDRHSREDRTASYRDSKESSRRSGNDKVSYDRKSDRPPYELAPPPFGSERRGYPDERPSMHPPLPAPKQEKKPESKNVDDLLKKPGRDSRPDRIVVIMRGLPGSGKTHVAKLIRDKEVECGGPAPRVLSLDDYFITEVEKVEKDPDSGKKVKKKVMEYEYEPEMEDTYRSSMLKTFKKTLDDGFFPFIILDSINDRVRHFEQFWSAAKTKGFEVYLAEMSADTQICAKRNVHGRKLKEISKIADHWESAPRHMIRLDVRSLLQDAAIEEVEMEDSEPSVEPQKEIKKQLPEEEESDRVYIPKSKWEMDTSEAKLDKLDGLKGSKRRRDWESVGSRLEDYLQLPDDYDTRESEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDKSGHLAERALNRTKYI
The following text describes a protein:
Function:
Iron-storage protein, whose ferroxidase center binds Fe(2+), oxidizes it using dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the BFR protein shell.
Sequence:
MQGDAKVIDYLNKALRHELTAINQYWLHYRFLDNWGLLDMAKVWRKESIEEMEHADKLTARILFFDGFPNMQVLDPLRIGQNVKEIIECDLAAEMSARALYQEAATYCHGVKDYVTRDLFEKLMSDEEHHIDFLETQLDLIGRIGLELYTQKHVGGLEGEGH
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases.
Sequence:
MAIARVNLAILCLSLIALLVLTTVPEAAGGQPGGYINYGAMSKNRSHGSPQYNHQGSSANHYTRGCEKQLHCRGKRRGF
The following text describes a protein:
Function:
Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repressor in association with the cell cycle regulatory factor efl-1 and the transcriptional repressor lin-35, but may also act as a positive regulator of cell cycle entry. Involved in the regulation of intestinal cell division during postembryonic development, most likely in complex with efl-1 and lin-35. Promotes germ cell programmed cell death, probably together with efl-1, by positively regulating the expression of the apoptosis proteins ced-3 and ced-4. In particular, positively regulates the expression of ced-4 in response to starvation. Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins lin-35, lin-37 and lin-52, and is independent of the ced-1, ced-8 and ced-9 pathways.
Subcellular Localization:
Nucleus.
Sequence:
MNPTNYDPRIGQPAQSRPQVSLSMGRRIVQMPTGLPRSYQDESHNEPVGWDEPSGVGGSSGAGGQQSDKPTGLRHFSTKVCEKVKEKGLTNYNEVADELVADYFQNNLIKQIDVVKQEYDMKNIRRRVYDALNVLLAMNIITKSKKDIRWIGLPASASQEISRLEEEKSRREASISSKKQALEEMVLQIVSYKNLVERNRKNEHKNGRPENDTVLHLPFLIINTDKEANVECSVSSDKSEFLFSFDKKFEIHDDFEILKKLNLACSLETTNPTAEEVKTAKSFLPTLHQHYVDEIIANRKKVEAEKEEKRKQQQLIADQMSMNLSQAQYVEPTSSLAQMSYSSRFNRQLQEHLINDGSEDRSAAAGIMERDYDMDKNVNQGSASRGPMYNTYSPQKIRAQVNTPLQVPPVTKRYYVQKTQGPMKHDMTPVVRTVNRPYSTVPPDRRLSTGATSVNSGPVKYYVPQGHQPMHQPVGQRYRVRPQQPQMSHMGQPHQVQQRVVYPAGSISGHQLQPGQRIVTQRIVAPGGPHPPGTIVRKVIRKIVVNNPKQSPAQQVIQKKMMEQDMCTFERKTEQPMTSAQAAALIQHPQPEEYDYFQ
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MQTLTIIRPDDMHLHLRDGDALKAVAPYTARQMGRAVIMPNLKPPVVSVADALAYKARIMAALPEGSAFEPLMTLYLTDNATPELVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIPVLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPVLAQVPNLKVVFEHITTAEAARLVLEAGDNVAATVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAHKFFLGTDSAPHAKSAKENACGCAGMFSAMTAIELYAEVFEKAGALDKLEAFASKNGARFYGIPENTDTITLVKQSQTVPASVPYGDGELVPMRAGGEIGWTVQY
The following text describes a protein:
Function:
This protein is required for high-affinity potassium transport.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MHFRRTMSRVPTLASLEIRYKKSFGHKFRDFIALCGHYFAPVKKYIFPSFIAVHYFYTISLTLITSILLYPIKNTRYIDTLFLAAGAVTQGGLNTVDINNLSLYQQIVLYIVCCISTPIAVHSCLAFVRLYWFERYFDGIRDSSRRNFKMRRTKTILERELTARTMTKNRTGTQRTSYPRKQAKTDDFQEKLFSGEMVNRDEQDSVHSDQNSHDISRDSSNNNTNHNGSSGSLDDFVKEDETDDNGEYQENNSYSTVGSSSNTVADESLNQKPKPSSLRFDEPHSKQRPARVPSEKFAKRRGSRDISPADMYRSIMMLQGKHEATAEDEGPPLVIGSPADGTRYKSNVNKLKKATGINGNKIKIRDKGNESNTDQNSVSSEANSTASVSDESSLHTNFGNKVPSLRTNTHRSNSGPIAITDNAETDKKHGPSIQFDITKPPRKISKRVSTFDDLNPKSSVLYRKKASKKYLMKHFPKARRIRQQIKRRLSTGSIEKNSSNNVSDRKPITDMDDDDDDDDNDGDNNEEYFADNESGDEDERVQQSEPHSDSELKSHQQQQEKHQLQQNLHRMYKTKSFDDNRSRAVPMERSRTIDMAEAKDLNELARTPDFQKMVYQNWKAHHRKKPNFRKRGWNNKIFEHGPYASDSDRNYPDNSNTGNSILHYAESILHHDGSHKNGSEEASSDSNENIYSTNGGSDHNGLNNYPTYNDDEEGYYGLHFDTDYDLDPRHDLSKGSGKTYLSWQPTIGRNSNFLGLTRAQKDELGGVEYRAIKLLCTILVVYYVGWHIVAFVMLVPWIILKKHYSEVVRDDGVSPTWWGFWTAMSAFNDLGLTLTPNSMMSFNKAVYPLIVMIWFIIIGNTGFPILLRCIIWIMFKISPDLSQMRESLGFLLDHPRRCFTLLFPKAATWWLLLTLAGLNITDWILFIILDFGSTVVKSLSKGYRVLVGLFQSVSTRTAGFSVVDLSQLHPSIQVSYMLMMYVSVLPLAISIRRTNVYEEQSLGLYGDMGGEPEDTDTEDDGNDEDDDEENESHEGQSSQRSSSNNNNNNNRKKKKKKKTENPNEISTKSFIGAHLRKQLSFDLWFLFLGLFIICICEGDKIKDVQEPNFNIFAILFEIVSAYGTVGLSLGYPDTNQSFSRQFTTLSKLVIIAMLIRGKNRGLPYSLDRAIILPSDRLEHIDHLEGMKLKRQARTNTEDPMTEHFKRSFTDVKHRWGALKRKTTHSRNPKRSSTTL
The following text describes a protein:
Function:
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. It has also been shown to be involved in formyl-L-methionine transport.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Domain:
Contains a regulatory C-terminal extension (C2) with a ferredoxin-like fold. The C2 domains from each MetN subunit in a transporter dimerize to form an eight-stranded beta sheet.
Sequence:
MIKLSNITKVFHQGTRTIQALNNVSLHVPAGQIYGVIGASGAGKSTLIRCVNLLERPTEGSVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVFGNVALPLELDNTPKDEVKRRVTELLSLVGLGDKHDSYPSNLSGGQKQRVAIARALASNPKVLLCDEATSALDPATTRSILELLKDINRRLGLTILLITHEMDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV
The following text describes a protein:
Function:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAIFAGLLTFVSTLLALALRRLLRLLRRRAPDPAAAAGFFHPYTNDGGGGERVLWCAVRAVQDLCPDLPCAVFTGDADASPDGLAARALDRFGVRLLRPPQVVHLNKRKWIEASTYPRFTMIGQSLGSVLSYTHYPTISSDMVERVKQRNSMYNNNSLISGSIWLSRCKVLYYTIFSWLYGLVGSCAHLVMVNSSWTRSHIVNIWEVPERMKRVYPPCDTSALQMLPLERSTTPPIFISVAQFRPEKAHGLQLEAFALALERLDSDCLKPKLQFAGSCRNKEDLERLQKLKDRSVELHIDELVEFHQDISYRDLVQLLGGAICGLHSMTDEHFGISVVEYMAAGAIPIAHKSAGPMMDIVLEEDSRQTGFLASRKEEFAEAILKVLRMPEPERREMAAAARKRAQRFSEQKFHEDFTNAVRPVLLGRS
The following text describes a protein:
Function:
Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MDDYDEFGNYIGEEVEEVVANGVEEVHIEEDQRIPDSDDEIEDDSKTEMVLNPDTAHLALEPMVRDMEVEGGNQQITLHEDKVYYPRMESVYGPGVEIVHNDRDGQSLEEPMVEPEREVIKEEGLPETTYQRDYQVAMMSQTEYIRNVSIVGNLHHGKTALCDMLIEATHKLTDEHSGHINGHVSRYTDTAAVEIERGVSTKTNPLSMLLADSKHKSHAMTFLDTPGHVNFYDEVICALSITEGALLVVDVVEGPLAGTKEAIRNAFRHSNTLTLCINKLDRLILDLRLPPADAYYKIANVIDEINIFIASEFGEERYFDPLTNVMFASAKFRFVFTLESMARKVTPNYTALTKRLWGNVFYNPETSAFSTQASSTAKRAFVYFVLEPLYKVFSTCLGEEPEKAVNMLSSLKLPKHSQKLDAEDLIRTACIAFFETYSPLVDILTRYIPAPKVGEEKEEAEKPTVVKVAKLIASADRESFYALSRIVSGSVRLGQKVKVLGAHYVPNEDEEDCADATITDLFVSQTRYKYTVVSAPVGNIVLIGGIDKTIIKNATVTTDKSIFPFSPLQFTPPVFKISIEPVNPSELPKMLDSLRKCQKSYPLLQTKVEESGEHVILGSGELYVDCVMHDMRLVFARDLNVKVSDPTTRFCETCVESSAIKTYAETPNKKSKITIIAEPLEEDVSKTISLGQITPTDKQGFAKLGYDALASRNVWAFGPTETSPNLLLNDTIPGEVNKQLLNSVKDSVVQGFMWATREGPLCEEPLRDVKFKVMDLDLADKAIFRGAGQIIPTTRRACYSSYLLAGPRLMEPIYSVHVTCPHAAVKVVLEVLEKRRGHLTSDTPIGGTTLYEVMGYVPVMDSFGLETDIRVATQGQALVSLIFNDWQVVPGDPLDRSIKLPSLQAMSGTSLARDFVVKTRRHKGLSDDPTVTKYLDDSLLKTLTESGLLG
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSHKEVENKPIHGNPPDEQLANGPIENRQCRDLICFLLFVGATAAFVVIISMGFNQGKPERLSYAYDPNGRACGHDDGVFNAPYIYLVAPLVGYLNRSVCVSQCPNWQEGAKQPTRLECVVNNVITNCSERYSYDGVNDIRDFDVNFLLNSDNYADEPSVDKLFNYSTFIYNSTSVLDRLCIPAGDKYVEKIYGNMDDIASVQVFQQWVADIRLTYKILFASVGIAFAIGLFYMLVMRYCAGTLTWTAIFLYFVCIVLFIIYLNDKANAYKTRAALNTAQGISDTDNQDLQTYYGLRGSMIGMCIIGGLSLLGLLCYFNRIRMAIAVIKTAALFVMEVPSVMLVPPIFSILVMGYWGLWIISFFYIYSMGDVKGSSDTPLATVEWNDNIRYYLIYHLFYGLWSNALLQAFSQFILASSACLWFYQHSDGQLIHFYVLESFKRSIIYHFGSLIFGALLLAIVQFIRFWLEYINYQMKQFQGDPKQPVKCFIDCLRCYASCFERFVSFINKNAFIQIALTGDNFITAAKNGFYLAWNNAGQFAVTSGIGSVFCTLCKLFIAFSTTFLCYMIITTSDTYKEKLNSPIVPTLLFFVISYVIGDLFMSVYGMAIDAILQCSITELELVKAKPGLLQKKRAPQPIQDFLEEHKKS
The following text describes a protein:
Function:
Presents an endo-cleaving activity on the homogalacturonan (HG) region in pectin. Active on homogalacturonan with a degree of polymerization above 4, and does not appear to be affected by the degree of methylation of the substrate. Does not degrade linear rhamnogalacturonan.
Subcellular Localization:
Secreted.
Sequence:
MMGKSVWVFAALFPAVLAADIYVSPDGSDDAAGTIDAPLQSIQLAVDQATAGSTIYLRGGTYTPTSNIQITKSGTASAPYVLRAYEGESVIIDGEELPGTPADLDASLDNADRGILHIQDAEYWEFYDLELINGPYGVYARDASNNHYERITTRNNYETGFQLQGESSNNVVLYLDSYGNRDPRKNGESADGFACKEGSGEGNILRGARLWNNVDDGLDLWYAVNPVHPRISANTSREFKSAVTIEDTIAWGNGFNRWDFTPFEGDGNGFKLGGGDDTDIGPADHIITNCIAFSNAKDGFTDNSQPGNFVLTRNTAWDNTAVGFKFGTAVATLTGNIAASNGEAPTSLSDEQISDGNSWDGDEDWDDGSFVSVDVSLVQGERNADGTIEPSGFLLPADGEEIGATTDWSA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
Sequence:
MISLSSHVLDTARGVPADNMNITLITPDGKEYQATTNDDGRCKDWGIEDFTPGVYHIRFHCKEYLLRHVDSTLYPFVDIHFEMTADGGHYHIPLLISPFGFSSYRGS
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MANAYNQRGGRVAVTNSDEVVGCVPLPYFLVRTDFLLSISLLQFMANEGLVPSPDETLKRRSIVLRLEKIVQDWITKVAWQRKRPENGISNASAGVIIYGSYGLGVHNSESDIDALCFGPFFATMEEDFFIGLHNVLKSTSGVSKIHCVKDAKVPLMRFIFEGIAVDMPYARLPENVDMLSPMLPTSIDETTLKILSGVRVNKRILQLVPHLENFQSLLRCVKFWAKQRGVYGHLFGFLGGIHLAILSAFICQTSPDFCLSALVLKFFNTFANWPWPIPVVLQGNTIQVVRDVIEKGWMPIRMPCSPSECCQSNVTRSTFTRIMNEFLRGHKLTMGILQPDFEWVNLFEPYSNMYRQLYSRFLKIDLLACAKDNLGDWIGRVKSRFPSLILKLEEMNVLCDPNPTEYVDQHSGNVDSKKSVVFYWGLGTDRPMDINVTSLEKDFRSNLSSGYRGMPGKMKLSIVPASELPNIVQLPKTKRMEACWRVPEHDQYRMPNSFTG
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEGPNSMEVGSLEVKKNDKDPWSKTAYLGGRLVSKIPAVYSNDNKFVFLTYDTFIGIFSLITGDCINRIFFPNNLANLLPVAVLLSPENAFELYVIFQSGYVCVHDWSNSELLRTMEISTRVHAASFSGKLLFAVTDTPASDSASSQDRFTLYALSPSTSKEGSSILIPTFVSKFNEFLALDSSLRDNNLATVAVITTDKAIFSLNVPKKKRSQRWIHREHLFNMPQKLTNVSLCGSACAVSDDEGKIHVINDISNEKFNPQILHWHANPLNGLSWALNGEYLLSGGQEGVLVLWQMETSHRQFLPRLGSSILSIATSHDSDSYALHLGDNSLVVIRAVDLAEQIHVSGINSFESKYLTSTGPKNTSKQLQGLVQFSSVSPNGELLLMSSSSFNGHSVSVQEYDLTKDSTIRKFEAARYSYSSVSKNSDDATSLDNGHVGSVAVTSSRNGLYIATIDTWCTNIIDEQQRNVKQTALKFWQFDSVQKTWVLMTRIDNPHGNLEVVTALKMMTSSNRFITVGTDATLRIWALLPGSSAWKCVAIHHFANTHSQASIKQRYGFSKALTCSLDDSIIGFGYGSCMHFINSETLEEISTVDLPHGGQLENAQFLNAEHCVIISQRRLLVWNVISASVQWTLASKFTGLLASSSSGNDFAVIDFNSSYSRLIIFSPDSPKIQSIHIFKTLPVALHYLHGGFVVLDNKSIIHVYAGDLTTKIPSAQLSIDNTSRSLLGDFQKRNVPLLNLENPISGSQGLHYKRLTTDMIHNLFNVPSNSPVNMQAIYNTFSKMAVGEPMESLGTQIATLNTE
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCTTGVSCACTGSCTCKECKCTSCKKSCCSCCPVGCAKCAHGCVCKGTLENCSCCA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.
Subcellular Localization:
Nucleus.
Sequence:
MDEIALRLPSTMTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLIQHNLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVRLADTHFVQRCPSVPTTENSDPGPPPPAPTLVINEKDMYLVPKLSLIGKGKRRRSSDEDAAGEPKAKRPKHTTDNKEPIPDDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFRLVLQKKHLEQKQVEDFAMIPAKEAKDMLYKMLSENFMSLQEIPKTPDHAPSRTFYLYTVNILSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTESNDSGEPFQVFTSADRIRQLNEIDKDVAKLIHSAGLAIQALTNARSNDSTTLASADNSLDSHKARFKEATSQYFALLSSIDVRLRRQVYALEEASILAPDSSSRTGDSGSGAAAGGASNPLDVSWLNSRKDTVGKEKEAELWAAARQFVQQIHQANSEDKATVKVEGEQETMEVD
The following text describes a protein:
Function:
Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis.
Subcellular Localization:
Cytoplasm, cytosol. Lysosome. Nucleus. Preautophagosomal structure.
Sequence:
MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSAGTDTNPIYMFLTGDERLPPTIYNSDADNELRRQVEESHRLPPALETVRQRAQLAQHMRELARKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLELLRNFPDDLKQLGRIPILPDLMSLAEADFHGFDELLDNDDVFTAQQQPTPQQQALTESSQADSPNKKLKMGDEVETESGEQTERGVQTLTSSSSLARRPNLNLLQWISSKGNHRALQLMSDECIQGLDVFSVEIYEKLKEEVNQIIKLANQADVKEIKGLGDRLCKLEEFKFRIKKMVQEQKEQALALQQNEARAQNLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCIANSKDELGWNLHTRLRRIVWIENGMSEFDNRLLFNHRCLRRAERHICIIEQIHRAPSTYVSAVAEVVRRKIFSDEFRQWATRLSADFDRIHSEELSRRRDFNASFEGHFLNILFPGMGDMPPAFANEHPLSFDTRLPSLSRSDMELLSSQLPELAGQLQLPDMKPVIDFFALRSDKNVEPDQEQERDIPLMAPRLAELQAQAAASDCETDTETEFEKLSTTSKCVATSISTSLVEQVAQSTATEDLLMLSAGTLTEENAGSFEKMRSDMESMTKLARACLAEARSNVGVFRSDVANYQDELQSELHLLRDKCNVLKMMCEEREQKLQEKLDEMSLKLQLAEQEKQAAVAQAREQLIHEHKTELESLRCRFKLMTSMERSPSDSSLEKIERPTSSASVVSANAGVDIDHLLAQQRQELLAQRERAISEAVDSERSLWQSRLLPLNSESVMANVGILKDMLADKERQLDQLREQNKILTQETYQLKTRLEMITNEDGNSWLKEKIDYLNKDKCRLEEELSQEKSRRQEMESSVAAMRSSAYDLNVGGPLTRSKSGVSSSHRSIALEGCARGDLVFVVWSMRHAQFMVVQDSLTLYFVHADSLASLQLTAPTSPTPSLDPSQTVVDINQIPLPYYAIGRVIDKEYCQARKDDNRYRVSRGSKFYRIKLAPLPSRNASRRERLESSSSIAAVVASPRDVIDAPSSNTSVYQSFKQRTVSITSVNEEDDESASLLSERCRYISVSEEDELHAAGGSMPAVTAAVATGTSTAASSATPITTAAPVAGGPTSTAPTAATQAQSVITEQPTASSKLKLDLLLASADIITQPLTQQPHQQRQELDQPAEAESTAPVAETSPNQTIQPEDPDPEPETITIYVPPNAPAVLTATPSTRASILASISAKPIISTDSMLPMSIGTAAISEDSDEYRSLEGKDDGDGDADDFPISE
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MGWFFSSKPRRRPPKYSSMAPPPPSLSSLLPHSHSFLPPQNPHLTHRYMPSPRPSHSLSFTTRFSPDNKLNDDKITYPPPQQEKKSFAVATGELFLGIASRVLRSRNKNSYNNNKVSGLSLLEKSDDGNVDYEERIRAVMEDEVEPVVIWEQRVKDIEAEKERPVVTSPGFCFSAAGLLFPYHLGVAHLLIEKGYIKETTPLAGSSAGAIVCAVIASGAGMQEALTATKVLAEDCRLRGTAFRLGAVLRDILEKFLPDDVHVRCNGRVRIAVTQILWRPRGLLVDQFDSKEDLINAVVTSSFIPGYLAPRPATMFRNRLCIDGGLTLFMPPTSAAQTVRVCAFSASGLGLQGIGISPDCNPENRATPRELFNWALEPAEDHILDRLFELGYLDAAVWAEENPVQNVVQDDIPLVENGSSSSQ
The following text describes a protein:
Function:
Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKVLVVDDEMLARDELKYLLERTKEVEIIGEADCVEDALEELMQSRPDIVFLDIQLSDDNGFEIANILKKMKNPPAIVFATAYDQYALQAFEVDALDYILKPFDEERIVQTLKKYKKQKQSQIETKHEIKGTDVTVEMHKLALPIEESIVLVNIEDIVYVGLVDGKVTVKTMRETYVTHDTLVILEKKLPQVSFMRVHRSFIANINHITEIQPWFNSTYNLIMKEGSKVPVSRTYAKELKKLLRI
The following text describes a protein:
Function:
Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.
Subcellular Localization:
Nucleus.
Sequence:
MAECQAGPAAGDWEIDVESLELEEDGRGAPLPTPPGPSPPPADEDDEDEDEDDAEDDGDGEDAGACPGVPGRPEQRGGPPPRPPPVPQASPPRAGPPERCASAGGSAEPRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQATEDKKGLSGKQNNFERKAVYQRQVRAPSLLAKSILEGYRPIPTETYVGGSLPLPPPVSDRMRKRRAFADKELENIMLEREYKEREMLEASQAAALFLPNRMVHGPEYNSYKSAYSPTPGEPPSKDFCNFLPTCLDLTMQYSGSGNMELISSNVSVAATYRQYPLSSRFLVWPKCGSISDTLLYQQCLLNATTSVQALKPGASWDLKGVRIQDGLSVEHDVMPPKLEGSLVLPHPLEVQTSRNELQGHQAVPERSAFSPPRRNFSPIVDTDSLAAQGHVLTKISKESTSHPLPLKHNPFHSLFQQTVNDKSGPELKTPFVKEAFEAAPKKHRERLVKENQKYTFTIDRCAKDLFVAKQVGTKLSVNEPLSFSVESILKRPSSAITHVSQ