lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MKQQRPNQAQEDIMIKDLQRVVQLNDLQAREILSLAQWNLQKAANSVLEIQKSGVKVEEQFKKYITNGQSVIDENGIISFCKDLGIDIMDPVILYISYMFKSETMGIYTKFDFLYGFSQLKVQSTSDLKRELKRLRDDLNNNREILKAVYKYCFDFAKKKNRKDIDLPIAQGLWDTLLTNTFPIMKKFMSYTIEEKDIKPISRDTYYMVWEFCVQIGEDLAKYDYKTGAWPTFIDGFYFYMNPLHRQ
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MRLVTLALGAGRGLLVLASEDGPPRRATYNLHAPSPEDLAHLAGQLGRGPRPLTRRVCLPTAGSAVIVPLIGGEDGSEVLGFLYADDPGTELPGDRVLGLARSVADQLALTLTRERLLTALRREEARYRQLAEGAHDLILSADAAGNVTYANPAACRLLEPLTGPLTGAPLLALPTPATREALHLAWDMALAHPAGGRAEITVAGYRLEVRLSAVQGSGPGGLGAGGVLLVARDLSELQTLADEIARRGQALEAATSRQSELRSYLALFTQAQEEERRRISRELHDDTAQVLIATARRVARLARDLDGPQRERADDIRADLDTAIESVRRFARNLRPSVLDDLGLLPALEWLASQAQTAARLEVSGPERRLSPAAELTVFRLAQEALSNVDKHAHAASAALRITFGESGVSLRVSDDGQGFTPEQAEARAQAGHLGLLGLRERVALAGGQLTVDSAPGRGTTLVFELPG
The following text describes a protein:
Function:
Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDKTAVLLLQMGGPDSLDAVEPFLLNLFSDRDIIRIGPAFLQPFIARLIAKRRSPGVERKYEEIGGKSPIRELTESQARALEDVLGDGYRCFVAMRYWKPSTMEALAAIRREGISRVIALSLYPHYSRATTGSSVNELKRVLSQSGVQFQMMYVDRFFDHPLYIDALAEKIREGLDDFHPLAEVQVLFSAHSLPQSFIDEGDPYLDHIRETVRLVMERFEGVTHHLAFQSRAGPVKWLEPSTDEMLEHLAAHQVKNLLIVPLSFVSDHIETLHEIDIEYAQEAHKLGYSRFRRSPSLNTSPTFISCLADLVRRVEG
The following text describes a protein:
Function:
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs); Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MLKPNFFFLSLRNLLSEIAFCPNSHDVHIYKKDGDKWSKIHELKEHNGHVTGIDWAPESNRIVTCGTDRNAYVWTLKNNVWKPTLVILRINRAARCVKWSPKENKFAVGSGSRLISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSSDFKSRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHSVCFSHSGDRMAWVSHDSTICISDATKKMRVTSLITDTLPLLCVTFITENSLVAAGHDCFPVLYIYDEAQGTLSFGGKLDIPKQSSQRGMTARERFQNLDKKASSDTNNITLDSLHKNSISQLSVLSGGKAKCSKFCTTGLDGGMCIWDVKSLESAMKDLKIK
The following text describes a protein:
Function:
Converts GTP to dihydroneopterin triphosphate. Is not active with GDP, GMP, ATP, CTP or UTP as substrate.
Sequence:
MALVKEVLVVLNRLSPFELQESWDNSGLNVGSENSEFSEIVACLEITLKIALNAPQNALIITHHPLIFKPLKTLNDEIYPGNILKILIQKNVSVISMHTNFDKTHLNKHFAHALLEFDGLVEKGLMLVKENANIEFDALVKKIKSSLGVGSLACVKSSQTIKDLAFVCGSGASMFSSLKAQSCLITGDVKYHDAMIAQSLGISLIDATHYYSERGFALIVAEILHSFNYLVTIENFKNPLQII
The following text describes a protein:
Function:
Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins).
Subcellular Localization:
Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side. Secreted.
Sequence:
MSGKGGVATYADRGAELREGFRKQSGESGGTFGRRGERQQAHKAMHLTWLVSAALLGLAACVPIERPKEKQEAETPPEAPDTGLYYHRYLQEVINVLETDGHFREKLQAANAEDIKSGKLSKELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDATMEQNVQIDHLSLLKQFEHLDPQNQHTFEARDLELLIQAATKDLENYDAAHHEEFKRYEMMKEHERREYLKSLDEEKRQQEEAHFEELKKKHKEHPKVNVPGSRDQLKEVWQETDGLDPNEFNPKTFFKLHDTNSDGVLDEQELEALFTKELEKVYDPRNEEDDMLEMEEERLRMREHVMQNVDLNRDRLVTLDEFLKSTQKKEFNEVDGWKTVDETQIYSEAELQRFEMELAAQEAELGRRAEQLRQQHQELQQRQVELDAQKKEYQQVVLQMEQRKSQQQPGQVPNAGPGGELKFQAQPPHAAPADQPVPPESHPAAPEQNPQENHVEPPQNQQHPEVETQ
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MAEVEDRDNNTRHHHHYISSTTTTQSPMNNFPRDLLRTFMGVNNNNNNNNNSNNNNHHNLPMPVVKLEEELELSLDLSMNGRFGVDPTAKKIKRTTSIPEFASDKEMGFATVGCTGSLVRTCSLPTETEEEWRKRKELQTLRRMEARRKRSEKQRNMKALREQQQRVVGVVGSQGSNPVDQGAGEYGEVAVAPPLARTVSLTTRVCGLGLNGDSEKEKKSGIVLPPPSPSQGSIGSSGISEAESQQGQGTTPMDVRSPTSANLLPDSELKSPAGVAENNTGKNAAAAVVTMRSQSNKHSPPQSRTKDIVRNLLEDMPCVSTKGEGPNGKRIEGFLYRYGKGEEVRIVCVCHGSFLTPSEFVKHAGGGDVANPLKHIVVSPSLL
The following text describes a protein:
Function:
Involved in the regulation of actin cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Note=Colocalizes with cortical actin patches.
Sequence:
MSEPEVPFKVVAQFPYKSDYEDDLNFEKDQEIIVTSVEDAEWYFGEYQDSNGDVIEGIFPKSFVAVQGSEVGKEAESSPNTGSTEQRTIQPEVEQKDLPEPISPETKKETLSGPVPVPAATVPVPAATVPVPAATAVSAQVQHDSSSGNGERKVPMDSPKLKARLSMFNQDITEQVPLPKSTHLDLENIPVKKTIVADAPKYYVPPGIPTNDTSNLERKKSLKENEKKIVPEPINRAQVESGRIETENDQLKKDLPQMSLKERIALLQEQQRLQAAREEELLRKKAKLEQEHERSAVNKNEPYTETEEAEENEKTEPKPEFTPETEHNEEPQMELLAHKEITKTSREADEGTNDIEKEQFLDEYTKENQKVEESQADEARGENVAEESEIGYGHEDREGDNDEEKEEEDSEENRRAALRERMAKLSGASRFGAPVGFNPFGMASGVGNKPSEEPKKKQHKEKEEEEPEQLQELPRAIPVMPFVDPSSNPFFRKSNLSEKNQPTETKTLDPHATTEHEQKQEHGTHAYHNLAAVDNAHPEYSDHDSDEDTDDHEFEDANDGLRKHSMVEQAFQIGNNESENVNSGEKIYPQEPPISHRTAEVSHDIENSSQNTTGNVLPVSSPQTRVARNGSINSLTKSISGENRRKSINEYHDTVSTNSSALTETAQDISMAAPAAPVLSKVSHPEDKVPPHPVPSAPSAPPVPSAPSVPSAPPVPPAPPALSAPSVPPVPPVPPVSSAPPALSAPSIPPVPPTPPAPPAPPAPLALPKHNEVEEHVKSSAPLPPVSEEYHPMPNTAPPLPRAPPVPPATFEFDSEPTATHSHTAPSPPPHQNVTASTPSMMSTQQRVPTSVLSGAEKESRTLPPHVPSLTNRPVDSFHESDTTPKVASIRRSTTHDVGEISNNVKIEFNAQERWWINKSAPPAISNLKLNFLMEIDDHFISKRLHQKWVVRDFYFLFENYSQLRFSLTFNSTSPEKTVTTLQERFPSPVETQSARILDEYAQRFNAKVVEKSHSLINSHIGAKNFVSQIVSEFKDEVIQPIGARTFGATILSYKPEEGIEQLMKSLQKIKPGDILVIRKAKFEAHKKIGKNEIINVGMDSAAPYSSVVTDYDFTKNKFRVIENHEGKIIQNSYKLSHMKSGKLKVFRIVARGYVGW
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MADEHQDVEDNTATTTTTTVGEDDLELSLSLRPLNCSNSYLPSSNLPKNLPETSSPAASNGQILSKRDAQALRRQEAKLKRELKRKSSLNNDVVGANPQQEDFMEEQRRKVLNLGFQGAAPPWFGLNAGAVYGGFMPYQGQNGNFTPRSEGKDAAGVSFSSGSSSGISDNYQSISGPGGNSSDAGSHSSHSHSPLPPPNVPTTSNTTSQIQRCSSQLDLQFNGLNPNHSKPQLCRSYSSNIELVTSSRQPCKSPEELTSLSMTCQQNVAQPNNDNTLSEKNPNSTPRSTIPKEAKVELGKPPKPVGLNGQQKLLFSEMPCVSATGNGPNGKTITGFLYKYSKAEVSIICVCHGTSFSPAAFVEHAGGENVEYPLKHIRVVPFALG
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions.
Miscellaneous:
MISCELLANEOUS: Encoded in a type III-A CRISPR locus.
Sequence:
MVQLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPDVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAKAYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLRLIADGVVDTRAFSKNSDTGAVFATREATRSIARAFGNRIARTATYIKGDPHRYTFQYALDLQLQSLVRVIEAGHPSRLVDIDITSEPSGA
The following text describes a protein:
Function:
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLTKRTHPMIGKISELLVGVNRSTAAPFFDVLMTSPKSPLDFKILPQISQRNSSKRFYDDNLGGSVGLGIVAALENSNTRRITSVCRSEPNQPGRSDPVQFMSHGGSTDGEDEEMFIMDEEDYTLVTCHHGPSGSCNTRVYDKDGFECFSSKINDDRRERLFVVDVVTESPENSPEFQGLGFLNSCYLCRKKLHGQDIFIYRGEKAFCSTECRSSHIANDERKERCRSKFSTSPYTAGQIFSTGVLVT
The following text describes a protein:
Function:
Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. May activate AfsQ1 by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTREHQGGTRGLAAARKGFWSGLRFTSLRLRLVLVFGLVALTAAVSASGIAYWLNREAVLTRTQDAVLRDFEQEMQNRAGALPEHPTQDEVQHTAGQMANSSQRFSVLLVAENADGTAVYGSSGGLGGVALSDVPESLRTAVNKEQKLTSANKHPYHLYWQRITDDGTPYLVAGTKVIGGGPTGYMLKSLEPEAKDLNSLAWSLGIATALALLGSALLAQALATTVLKPVHRLGVAARRLGEGKLDTRLRVSGTDELADLSRTFNSAAENLEKRVADMAGREQASRRFVADMSHELRTPLTALTAVTEVLEEELEYAGEGEGEGGSFDPMVEPAVRLVVSETRRLNDLVENLMEVTRFDAGTARLVLDDVDVADQITACIDARAWLDAVDLDAERGVHARLDPRRLDVILANLIGNALKHGGSPVRVSVARADHEIVIRVRDNGPGIPEDVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAENAPEGGAVFTLRLPQDPSPPADEDGGPDEETEDRGKDAKGQV
The following text describes a protein:
Function:
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s); Binds to mRNA to regulate gene activity at a post-transcriptional level (Probable). Represses expression of many toxic extracellular enzymes and compounds; decreases translation of lasI and rhlI. Positively controls swarming motility and rhanolipid and lipase, possibly via expression of rhlA; activates transcription of the CsrA/RsmA antagonistic sRNA RsmZ. Overexpression dramatically reduces extracellular protease, elastase (lasB) and staphyolytic (lasA) activities, decreases HCN production, decreases levels of autoinducers 3-oxo-C12-HSL (3-oxo-N-(tetrahydro-2-oxo-3-furanyl)-dodecanamide) and C4-HSL (N-butanoylhomoserine lactone), and abolishes production of cytotoxic internal lectin PA-IL (lecA). Control of hcn expression is post-transcriptional. Replaces endogenous gene(s) in E.coli and P.fluorescens; Probably binds to and is sequestered by non-coding small RNA (sRNA) RsmZ; overexpression of rsmZ produces very similar phenotypes to deletion of rsmA, while rsmZ deletion has no phenotype.
Subcellular Localization:
Cytoplasm.
Sequence:
MLILTRRVGETLMVGDDVTVTVLGVKGNQVRIGVNAPKEVAVHREEIYQRIQKEKDQEPNH
The following text describes a protein:
Function:
Acts as a transcriptional regulator that recruits coactivator IFH1 to the promoters of ribosomal protein genes. Recruited to ribosomal gene promoters by RAP1.
Miscellaneous:
MISCELLANEOUS: Present with 639 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDGEMAIIESSNHVGTSSPTTETQFTIDSSALKDQETKESITNSPTSEVPIETKLPKSSDIVTEEKHPQNTTTDIENEVENPVTDDNGNLKLELPDNLDNADFSKLLEFDAKNDEALFNSNELLSHTMDPVNNIDLTHDHSREVSSKEDINIEPVNPDEDEREKTQDNTAAVKTEGIRNSEDTSIQKDEPTADAIYTDVHKLSVNKDTETLPTLVDEKNNMLHMRNNSITPIMFQQHELVGQPPQNTVTENNSTDAETTQRKLSEPIDASLPLPNEQPTIFAYARLDFQSFTFYVQTLHAIIGRRSENDFSHKVDVNLGPSKSISRRHAQIFYNFGTGRFELSIIGKNGAFVDDIFVEKGNTVPLRNKTKIQIGQIPFQFILPEQERNDDSKSPENADIAESEINTRNLKKNEPKSKKKITTGAKPKKAQTKPAVKKEKKPPKIPKKVYTLEEIPVEYRTKPTVSYSAMLTTCIRKYSTAKGMSLSEIYAGIRELFPYYKYCPDGWQSSVRHNLSLNKSFRKVSKEGKGWLWGLDEEYIAERERQKKKQSEIAVAKAQAAQLKLEQQQHKLQQVPQRGKKDIVSQRSNVNARKQNISQTLAANRAASNRKNTASDNQRTMKYLQEQLVILTRDRKGLSKQVIAAILTQALAMTINQVTQAAKNKGITGNPLTALMDKNPQHLNLILAAAVNAATAKVTKGEVKQLVNPETTAAAALAAKAQHSKPIRQPIVQTPHVPDRPPSQLSASASSHPNNYLHDKQPGSFDPSSLSRFFQPRQNARATSSVAATSVPAAASQNVDAQPKPKPAQDNDLESESGTSSSSSSSSESGSESDSGSDDGSASGSGDNSSTSSESESESDSGSEVDEKNNKNEKIDSESIKNNESKDDIPSKDENSSNDNREISKTDEEGHDSKRRKVSEDINEGITEVNVSLEEKL
The following text describes a protein:
Function:
Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the plasma membrane that mediates sucrose-induced Ca(2+) influx in autotrophically grown leaf cells. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Plays a regulatory role in defense responses.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSEAEAPLITEEAAERGLASSGSRRLSDGAGGQGSRKYRRRSDALAHGDRYQKAAALVDLAEDGVGIPEDVLNDTRFGRAMSFYFVYLRLDWLWSLNLFALILLNFLEKPLWCRKDALQACDQRDLYFLGQLPYFSKTESLIYEGLTLVILVMDIFCPLSYEGLNIFWRSTTNKLKILLLFILACDILVFAFSSQPFRLAPYIRVVFLIMTIRELRMCAITLAGLIGTYLNVLALSLLFLLFASWLAYVTFEDTPQGKTIFSSYGVTLYQMFVLFTTSNNPDVWVPAYKISRWYSLFFIVYVLLGVYFLTNLILAVIYDSFKEQFAKQLVQVDSIRKNILQKAFDLIDTNNRGYLDREQCISLLNELNKYRSLPKTSREDFELIFAELDRSGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEKFPFYHSPLCGRLKSFVRSRVFEFIIIFVLLVNLVAVIIETTLDIENSSSQETWQEVEFFLGWIYVAEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAFPSKLPFLSNGEWIRYLLLGRVLRLTRILLQVQRFRAFVATFFTLMSSLMPYLGIVFCVLCMYCSLGLQIFGGIVYAGNPTLEETDLFNNDYLLFNFNDYPSGMVTLFNLLVMGNWQVWMESYWQLTGNSWSLIYFVSFYLISILLLLNLIVAFVLEAFFAEMELEKGEEVDIQNPTSGGIKKRRSMRVRSKGTMVDILLHHMLSNELDGSQNS
The following text describes a protein:
Function:
Possesses potent anti-fungal activity.
Subcellular Localization:
Secreted.
Sequence:
DKLIGSCVWGAVNYTSNCNAECKRRGYKGGHCGSFANVNCWCET
The following text describes a protein:
Function:
Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSAGNGTPWGSAAGEESWAASGVAVEGSELPTFSAAAKVRVGVTIVLFVSSAGGNLAVLWSVTRPQPSQLRPSPVRTLFAHLAAADLLVTFVVMPLDATWNITVQWLAEDIACRTLMFLKLMAMYSAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLALPQLFLFHTVHRAGPVPFTQCVTKGSFKARWQETTYNLFTFRCLFLLPLTAMAICYSHIVLSVSSPQTRKGSHAPAGEFALCRSFDNCPRVRLWALRLALLILLTFILCWTPYYLLGLWYWFSPTMLTEVPPSLSHILFLFGLLNAPLDPLLYGAFTLGCQRGHQELSIDSSNEGSGRMLQQEIHALRQQEVQKTVTSRSAGETKDISITSI
The following text describes a protein:
Function:
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
Sequence:
MGNSLLRENRRQQNTQEMPWNVRMQSPKQRTSRCWDHHIAEGCFCLPWKKILIFEKRQDSQNENERMSSTPIQDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRESLGGTETEYSLLHMPSTDPRHARSPEDEYELLMPHRISSHFLQQPRPLMAPSETQFSHL
The following text describes a protein:
Function:
Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling. Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms.
Subcellular Localization:
Secreted.
Sequence:
MEKLLLILVLSIQPYNFGGDVLPPLHANHMIRARSPLPIGQRVDGFLRVDKSSRFYFVTNGSHDILTLRVTPCESPLIWTLSSVHDKKAHGAGEINIGHLKPFDQRLHTRTLFSFQGNGEETFTTGVTSDSLFLLDIASLESDTSFQVFVWDHKSQGNLWPQLPNDSQLEITSVEEDRIKLSWKPSLGDIKKINYCVFVNKQHNVKTLCATMSNTNKRFSNQLNENDGKSSRSLEIAMKTSKTYSNKLKEDVMEQNVNADFFSSKNFVGAQKICVGHWTNATISRLKSKTLYYFDVFAVNSHTGTSLAYTGTFAETKNKHRSQLATLHNDEMVNIFLKSKVLRMMTVDLPDHGSKWLFIHSCLHKVHLKISVNGKVIVSQNIHRAHNFKLSGTPKANCIITLKSSKGGPGLVKIFSTTAHHNLPFPNLFSNISFSVSKSTCSSATVRWTGSGHGTEYCIYARHLEQNLDLKLIHRHQNSCLSTKTRSKAEKVFCNHAGPHTSIEEEITDLKPGKTYLLDLYLIGLHNSTIKFPSRVVRTQGLCT
The following text describes a protein:
Function:
Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis. Required for the normal localization of MSH4 to chromosomes.
Subcellular Localization:
Nucleus. Chromosome. Note=localizes to a meiosis specific chromosomal structure called the synaptonemal complex (SC) formed during meiotic prophase.
Sequence:
MIIERWEVKLSKCNQNVGGYSVLSGNLKENIKLGRRAQKYLKELRNLQLKPLKIGGYENCGTINGEEYFLEVIHITSGRQKIDVAVGKTWNVTNIENDNKEELQYELFKEKLKVGKQDMLFFSWMKSLSVQLNAPLHQKMTEHGLADDNTRLEWFNIPLLRRSQYRKKVPYPSLRQMSSVLEVQCSTLTEEKLNFCVGFSDKPLSEWKPQIFEQTYNRYRLQRISPEKSFKYKSRCSKYNFKTSSQSWVVKVPEHDQQLNTFEKRYDELFDAQFNKLEFFKIRMKKLKKNKPIEKKNYKIWCLEKEDLKDLVWDPLKRICNHSRYAIFEHVTINREAYSIKPLRLTFQKLDSGSLDLIDNQKKTFGSIKLAMSMPDVKKTENQSIEESERHDETAIETQEFDENDCLSSKADINTSLAPQKRSFIDNELMSMLVTKKKIKKDKDVSDTGISSTSYLINSGTYANSHIEIPTSNSVYNGKEDCSFNNYSVKHSILEEDIENKCIAVNENKVIENQKVIQSLCKNSHLDLIEQSYFGECDFIINHSTCVYKIQASRFMQLRNNGSLHYDKAVNDLLTEFQRVIIIVEFSEIIQDVDPDLFWKIKLYLLNSRVDVFFIHETTDFFIDWMKYFIARWAFSYNDEKEKNIANADILLDLGFNILLVRKIFQTYSLEEFFMAIIKEESKAVKMLTVSQMTRLKKLLTLEW
The following text describes a protein:
Function:
May be involved in a process influencing telomere capping.
Subcellular Localization:
Cytoplasm.
Sequence:
MTERFGVVLKKRSKELWLRELYRSLAIYDKGARPEIEDKQKGTVNEKQTEAAATNSSLGFAVDAPDDGDEGDNQEDDELVLAALESMDATEVFKHGEQSNVHHSIIPTDNLLKLVELLLLIAPIDPQQSISSLSPDLSQGRVEELRRAANVIMLSFGVENHPGVTYNTFNTVVSLCMPHLFNGLHPLFEHFLFAKDFDLSKRKGGSTTPTAETKPVIPPPKPVTEPEPLLRDPGEILNLTILSQLSFFIDGNQLFRRLRPLYRGNQHGFSMGSFEKQVFNWRAPTILLVKGRLLPAKASSTRERALENLLPPKRYPSSIPETATNQSLVYGGFVPSQWKNTGKACFGDANTKLFQLSPTHDVFSPSQYADNYVYFNKSPTHPPGLGFGTKIPLQSSAHSHSQETFKPGVVSLHLDDALEFGIFTHISGGGGTFHSSGLPCRKGKDWQDRFEIEEIEVWGCGGDEVAEAQRKEWAFQEREAEARRRINLGTGDVELDRELLKMAGIIGGSQSGGSMG
The following text describes a protein:
Function:
Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high affinity to the free 50S ribosomal subunit. Does not bind it when it is part of the 70S ribosome.
Sequence:
MKEKPAVEVRLDKWLWAARFYKTRALAREMIEGGKVHYNGQRSKPSKIVELNATLTLRQGNDERTVIVKAITEQRRPASEAALLYEETAESVEKREKMALARKLNALTMPHPDRRPDKKERRDLLRFKHGDSE
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFLMAASGVSELSVPFPSSSLARIALGSLAPDPEPRKGGISKELSVTEDTLHVRWRADEARILRVSVSSFLEHLSLVVETMDLFGPPVA
The following text describes a protein:
Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
The following text describes a protein:
Function:
Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions.
Sequence:
MSSPEPPTEPPEPDNPTWSTQPTYSNLGQIRAHLLPSKACRLRTPGSLSTNPEPLPPPLPKKILTRTQSLPTRRTLHPSSIQVQPPRRPFLGSHSVDKSQAAVGPACLPAELTFGPADAPLGLSLRDLHSPEAVHTALAARQLQGLRTIYARLRARLMGGHPGPCHPGHSFRLLDSSPCAESGDALYYRVVRAHEDAWHILVAKVPKPGADVPHPWGLELQASLSPHFNLQGLCGLVPEGTLPGAPWRGAVALAAEVPERTVAQWLAEACTQPPEEFVWAVALLLLQLSAALKFLEAWGAALVELRPENLLLVAPRGCATTGPPRLLLTDFGRVCLQPPGPPGSPGPHAPQLGSLLRALLSLAAPSTTPLAAGLELLAAQLTRLRPSASRTRGALQALLWGPGPELRGRGAPLGPWLRALGPWLRVRRGLLVLRLAERAAGGEAPSLEDWLCCEYLAEATESSMGQALALLWD
The following text describes a protein:
Function:
May play a role in embryogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAMISFSFPSPAKLPIKSQPSVSNRINVADRLILRHLNAGDLRGAVSALDLMARDGIRPMDSVTFSSLLKSCIRARDFRLGKLVHARLIEFDIEPDSVLYNSLISLYSKSGDSAKAEDVFETMRRFGKRDVVSWSAMMACYGNNGRELDAIKVFVEFLELGLVPNDYCYTAVIRACSNSDFVGVGRVTLGFLMKTGHFESDVCVGCSLIDMFVKGENSFENAYKVFDKMSELNVVTWTLMITRCMQMGFPREAIRFFLDMVLSGFESDKFTLSSVFSACAELENLSLGKQLHSWAIRSGLVDDVECSLVDMYAKCSADGSVDDCRKVFDRMEDHSVMSWTALITGYMKNCNLATEAINLFSEMITQGHVEPNHFTFSSAFKACGNLSDPRVGKQVLGQAFKRGLASNSSVANSVISMFVKSDRMEDAQRAFESLSEKNLVSYNTFLDGTCRNLNFEQAFKLLSEITERELGVSAFTFASLLSGVANVGSIRKGEQIHSQVVKLGLSCNQPVCNALISMYSKCGSIDTASRVFNFMENRNVISWTSMITGFAKHGFAIRVLETFNQMIEEGVKPNEVTYVAILSACSHVGLVSEGWRHFNSMYEDHKIKPKMEHYACMVDLLCRAGLLTDAFEFINTMPFQADVLVWRTFLGACRVHSNTELGKLAARKILELDPNEPAAYIQLSNIYACAGKWEESTEMRRKMKERNLVKEGGCSWIEVGDKIHKFYVGDTAHPNAHQIYDELDRLITEIKRCGYVPDTDLVLHKLEEENDEAEKERLLYQHSEKIAVAFGLISTSKSRPVRVFKNLRVCGDCHNAMKYISTVSGREIVLRDLNRFHHFKDGKCSCNDYW
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
METNQNEKGPSLPSYPAGGIMSVSNSNADTNQGVTQHPLANRIVNPNYYNMGFNPYSGFNSFIPSFNPFVPLETNLPGNGPISSLQVIESIVGAVGSIAQVLESTLMAAHMSYNTFVSVSENLNKLKSSIGAIFGIVSLLSRLKRLVLKFFKHSKIDEMNSQEYDVFEKEEGNHKNSIYSIVSSLAIILGLVGLPYAIIRLFKNIYEKEKQIQQAKIRKKIDSLEFCKADYEFMSRDPGVEMSLKKGDIIAILSKTDTQGNPCEWWQGRKRSGETGWFPSNYCSIISR
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSGSVGESRSSRRRTAAKSPRYDRSITVFSPEGRVFQVDYARNSVKLEGITSVAVRGADSVCVITQRTKAPADPLLDTADPPFMHLFQITERLGMLATGMPGHDDTLPFYLSTSVLLTGIFVTEADGRALAQQARNEAAGFRYKWGYEMPPKMLAQWLGDRAQVRTQHDGMRPYRVVATVVGIDEEKGTPELFTCDPAGQVLGHKATSVGLEDQEAIEFLEEAMAGNSSLSFQETMEMAVSALRHVLEDNNQGHDIEVGVVRKNYPTFRTVLRRIYKNPLAGQNILDGEGQ
The following text describes a protein:
Function:
Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13.
Subcellular Localization:
Secreted.
Sequence:
MEVKIFAFLQIAVLIAFSLHLASAGSKELSGPESSENSIEAAFCDTNCTEGTDGVWSGCSAGCFCVHVGNSTVGRCMTFNGVD