lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
GDP-GTP exchange factor for TEM1, a Ras-like protein, component of the mitotic exit network (MEN). Activation of TEM1 by LTE1 in the bud ultimately leads to activation of CDC15 followed by the release of CDC14 from the nucleolus, which then inactivates cyclin-dependent kinases (CDKs) activity by several mechanism. Required for TEM1 localization to the bud cortex during mitotic exit. Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis; Involved in proprotein-processing like proalpha factor-processing in the secretory pathway.
Miscellaneous:
MISCELLANEOUS: Present with 304 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Bud. Note=The localization to the bud requires interaction with KEL1, as well as the presence of septins, CDC42, CLA4 and RAS2.
Sequence:
MEIFSQKDYYPTPSSNVISYESDCVSKPVNSADLPALIVHLSSPLEGVDYNASADFFLIYRNFITPQDLHDLLIYRFRWCIREITTNAAKAKRRRIGEVALVRTFVLLRHSILNYFVQDFLPNITLRLRLIEFLNDKHIEQYPKIISSCIINLKKNWVHCSKLVWENIELNEPDKLDFDAWLHYSLKDFTQLESLHKRGSRLSIYARQSFASPDFRNQSVLSLYKTSDVFRLPEKLQSSNSSKNQRSPSMLLFPDNTSNVYSKHRIAKEPSVDNESEDMSDSKQKISHLSKVTLVSTLMKGVDYPSSYAVDKIMPPTPAKKVEFILNSLYIPEDLNEQSGTLQGTSTTSSLDNNSNSNSRSNTSSMSVLHRSAIGLLAKWMKNHNRHDSSNDKKFMSAIKPANQKPEMDAFVKYVVSISSLNRKSSKEEEEEFLNSDSSKFDILSARTIDEVESLLHLQNQLIEKVQTHSNNNRGPTVNVDCERREHIHDIKILQQNSFKPSNDNFSAMDNLDLYQTVSSIAQSVISLTNTLNKQLQNNESNMQPSPSYDALQRRKVKSLTTAYYNKMHGSYSAESMRLFDKDNSSSRTDENGPQRLLFHETDKTNSEAITNMTPRRKNHSQSQKSMTSSPLKNVLPDLKESSPLNDSREDTESITYSYDSELSSSSPPRDTVTKKSRKVRNIVNNTDSPTLKTKTGFLNLREFTFEDTKSLDEKKSTIDGLEKNYDNKENQESEYESTKKLDNSLDASSEANNYDITTRKKHSSCNHKIKQAVVRPASGRISISRVQSIAITPTKELSIVDPEQNKSNSVIEEISEIEPLNLEYNKKSALYSDTSSTVISISTSKLFESAQNSPLKQTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTGSTVETFETSRDLPVPHQRIINLREEYQRGNQDIISNTSSLHELKTIDLSDSNNDLESPSTHAKNNKYFFSPDDGSIDVASPMKNVEELKSKFLKNESETNSNISGSVLTMDDIDINDTSSARNTRRANSESAFTGSLNKKNLNEIANMLDDSINDDPITVALMKLEGTYEKIPEKPENTKSSDAIGIKTSKLADEVEMLNLNNLPSFQNSPAEKRKSLLIERRRQTIMNIPFTPDQSEKEGFTSSSPEKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISNNESHVPFILMYDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSGIDLAISRFNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFTDAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLLNSVNPLVGCVPFIVVYLSDLSANAEKKDWILEDKVVNYNKFDTNVQIVKNFIQRVQWSKFYTFKVNHELLSKCVYISTLTQEEINELST
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; There are 2 NADH dehydrogenases in E.coli, however only this complex is able to use dNADH (reduced nicotinamide hypoxanthine dinucleotide, deamino-NADH) and dNADH-DB (dimethoxy-5-methyl-6-decyl-1,4-benzoquinone) as substrates.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIPLQHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
The following text describes a protein:
Function:
Probable RNA-binding protein that may play a role in growth regulation.
Sequence:
MPSKVMDQRGITPMYAPSEPSSFFSDEASFPAERHVGFWKPEPTSDLSDTELMSASGPVTSSPHDKNLRELIVSSAKSLESAQWGLGDMVGDEKINSVLGTPWKPTSNDFLVHRSNHLVQPANYFSNGSKVDLNVVHLENGSFSSSLSEIFNKKVTLSSNNNFFGNSNDTTKLKFEEEIFASLEEMEARTIGNLLPDDDDLFDYISQPNTKDYAEEDIFCTVGGMDIEDINSLGSLNGLELSNITSNDPLGELNSYSSGKHPYGELPSRTLFVRNINSNIEDTELRDLFEQYGDIHTLYTACKHRGFVMISYYDIRSACNAMKELQTKPLRRRNLDIHFSIPKDNPSEKDINQGTLAVFNLESSVSNDELCQIFGVHGEIKEIHETHNQHHYKLIEFYDVRASEAALHALDMSDIAGKQIKLESSFPGGLRNSIQKLSLDLQKDEIDGCRQQSSPKKSLTGNYESISIGEIVSGGSDSTNVHGFQPVSQSPVNSSVDGIFNGTPSNTPHNFPSMRSGSFGNHSDFSHSPGMRNFGFHPMQNFHPHSLPENQGNIPQRIPYNMENSISTMAANISRSTEDIDNRNISVGLARFGGQNGNGGYTVHGHQFAWQNSFHNPTGPVLWPNSPSFANHIPRRPTSQVHRFTATPAPHHNVGSAPTSNPSLWDRHHAYAGEPIDASAFHPSSLESMGYSGSPTLNHVEHGSHSIFPHVGGNFMEPPIPPMHIGMSSPHQNFHIFHGRSGMISMPNTFDFPGDRTRIRRGDISSNQGDNKRQYELDIERIISGEDTRTTLMIKNIPNKYTSKMLLSAIDEHHRGTYDFIYLPIDFKNKCNVGYAFINMINPQQIIPIYKVFNGKKWEKFNSEKVASLAYGRIQGKAALIAHFQNSSLMNEDKRCRPILFHSVGPNAGDQEPFPMGVNIRSRPGRSKNHNNDDHHQDDMLNSVTEMNSNGFTSSSSSTKDLE
The following text describes a protein:
Function:
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
Sequence:
MARVTVQDAVEKIGNRFDLVLVAARRARQIQSGGKDALVPEENDKVTVIALREIEEGLITNQILDVRERQEQQEQQAAEIQAVTAIAEGRR
The following text describes a protein:
Function:
Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition. Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair. Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells. Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements.
Subcellular Localization:
Cell membrane.
Sequence:
DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS
The following text describes a protein:
Function:
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.
Subcellular Localization:
Mitochondrion.
Sequence:
MAATLWRLYSKSICNSLQGIILNKPFIQKQLLLSSRTRSLSFSSDSQFGSATAEVCSNTGLKTGGGIIVKEGFLRWENGGGTCHSSAQIYSSALVEFGAVVHEKAVLGAEVHVGSGTVIGPSVDIGPSTRIGYNVSISNCSIGDSCVIHNGVCIGQDGFGFYVDEHGNMVKKPQTLNVKIGNRVEIGANTCIDRGSWRETVIEDDTKIDNLVQIGHNVIIGKCCLLCGQVGIAGSVTIGDYVALGGRAAVRDHVSIVSKVRLAANSCVTRNITEPGDFGGFPAVPIHEWRKQIVRAQIANKREI
The following text describes a protein:
Function:
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Sequence:
MRHLVLRREGGVKFYAPDPEKYGGIYSAPVFYNPAMEKNRTLSTLLLKAYGKGGLVVCEPLSGTGVRGIRYAVESGVVGKLILNDISKEAVELIKKNLEINGVDAEVYNEDANVLLHKLKDSCDVVDIDPFGSPAPFIHGAFRALKEEGLICATATDTAVLVGRYPRKCLRRYGSVIVKTPFYIEVGLRNLLGYIARVAAAEDYKITPLMSYWEGHYFRVCAYAARGARDADDNFHHIAYIKYERGVRKILHAQSEGSSGPLWVGPLGDPLIINKMSEIGPYQDFLKILAEEYSISAPWFYRLPEFAAGGKSPTLKEAVGVLRAAGIYAVRTHMAPDGFKADGEYGEVLMAFKRYISSAHSLQ
The following text describes a protein:
Function:
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway. Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells and is essential to maintain the complex on chromatin.
Subcellular Localization:
Nucleus.
Sequence:
MFGFRKPKMYRSIEGCCICRAKSSSSRFTDSKRYEKDFQNCFGLHEARSGDICNACVLLVKRWKKLPAGSKKNWNHVVDARAGPSLKTTLKPKKMKTLSGSRIKSNQISKLQKEFKRHNSDAHSTTSSASPAQSPCYSNQSDEGSDTEMSAGSSRTPVFSFLDLTYWKRQKVCCGIIYKGRFGEVLIDTHLFKPCCSNKKSATEKPEQEGPQSPAISTQEEW
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Sequence:
MDPNCSCATDGSCSCAGSCKCKQCKCTSCKKSCCSCCPVGCAKCSQGCICKEASDKCSCCA
The following text describes a protein:
Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
MSSSIEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHPMAASDGDFGGDLDAAALAYEQVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAVLESTRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVGRQNTLWLLDRDAAAKLPS
The following text describes a protein:
Function:
Mediates the induction of a number of unlinked genes involved in purine utilization. Binds to the consensus sequence 5'-TCGGNNNNNNCCGA-3'.
Subcellular Localization:
Nucleus.
Sequence:
MLNPSTSDIHTSPTAVGNGRKRPHPIADSGSAMPSDPSAQQLPHPANESAAIPSIASSSSFRNVSACNRCRQRKNRCDQRLPRCQACEKAGVRCVGYDPITKREIPRSYVYFLESRVAYLEKVLMDNGIEYNEAVAFDEEEAVKIEAGYEAYAGSANGPAAGEIAAQDGSNDKSVRIKKEKNGPLGLEKASRYDHDPEVKQDSDAEDGWRIQNLVSNIGMVSVQGTSDPRYLGSTSGISFARVVFAAVKSSVPGNSSERGPSRPKERLPHSATGTEGSTTRDSFFGLQTRPMMKCAAFPDRELAERLADLYFEHANPQIPIVHRVDFMELLDRTYSVDEKSRSPRSLYFLNIVFAIGSGIIFEDKPAEDQKEGRDHSPSATKRQRLSSRQYQPEEYHASAIVHLESFLSTSPTTDGFGALEELQAVLLLASFALLRPVAPGLWYIVGVAMRLAVDLGLHYEDGAGIDGPENDNMNRTNNKDGEKAKLRIDDHERGRREWVRDFRRRLWWCCYSFDRLVSCCVGRPFGISDQAISTEFPSILEDKYITKSGIIKAPEGAPSYKHSAFHYFKLRVLQSEIQDVLQHQQARFARQRGPPGARSFMRLDVVSPFLQGFDSFRSWRRDVDRRLLEWKNSAPMPSENGVRFPLEFLELNYWQAVIMLYQQSLTVPAELADELSPAEDVSSPSFSQVEEDEHDIYYKVAEAGQKVIRIYRQMHRVRLVNYTYLATHHIFMAGISFLYAIWHSPYVRSRLTLDEVDFTVLAATSVLRDLMHKCPPAEACRDAFERMSKATVEMSLSTTGFGPQVELNRVQTSTSGSRQFNATQSRSRPYSRQQAEQRQRQSASRRQLQMRQSRPLPRFDMNLEDLFGDNRAVAERQGSGGMGKLAQPYPVSETSDPNFARPQSHRNPSMEYYGPFENPVSPQQPQPQPRYYYNNSPQQSGSPGSVVAASGIPPYQVTPTEQENPSGMGLDYLDYDPTGIERQLSLGSEENSDFKFQGGAQSLGHGAGHNFGIDLGFGMAVDFQHDWSENANYDLLEGYFFGGAGATGPGHGHGHGSGI
The following text describes a protein:
Function:
Probable transcription factor involved in the regulation of time of flowering through the photoperiod flowering pathway. May repress FT.
Miscellaneous:
MISCELLANEOUS: Under epigenetic control. In wild-type plant, FWA is silenced in the sporophyte. The epi-allele fwa mutants (which do not have a change in the nucleotide sequence of FWA) cause a late-flowering phenotype due to ectopic FWA expression in sporophytic tissues. Repression of FWA is dependent on histone H3 'Lys-4' methylation and cytosine methylation which are partly controlled by the lysine-specific demthylase 1 (LSD1) homologs, LDL1 and LDL2.
Subcellular Localization:
Nucleus.
Sequence:
MNGQGDLDAVGNIPKPGEAEGDEIDMINDMSGVNDQDGGRMRRTHRRTAYQTQELENFYMENPHPTEEQRYELGQRLNMGVNQVKNWFQNKRNLEKINNDHLENVTLREEHDRLLATQDQLRSAMLRSLCNICGKATNCGDTEYEVQKLMAENANLEREIDQFNSRYLSHPKQRMVSTSEQAPSSSSNPGINATPVLDFSGGTRTSEKETSIFLNLAITALRELITLGEVDCPFWMIDPIVRSKGVSKIYEKYRSSFNNVTKPPGQIVEASRAKGLVPMTCVTLVKTLMDTGKWVNVFAPIVPVASTHKVLSTGSGGTKSGSLQQIQAEFQVISPLVPKRKVTFIRYCKEIRQGLWVVVDVTPTQNPTLLPYGCSKRLPSGLIIDDLSNGYSQVTWIEQAEYNESHIHQLYQPLIGYGIGLGAKRWLATLQRHCESLSTLSSTNLTEISPGLSAKGATEIVKLAQRMTLNYYRGITSPSVDKWQKIQVENVAQNMSFMIRKNVNEPGELTGIVLSASTSVWLPVNQHTLFAFISHLSFRHEWDILTNDTTMEETIRIQKAKRHGNIISLLKIVNNGMLVLQEIWNDASGAMVVYAPVETNSIELVKRGENSDSVKFLPSGFSIVPDGVNGSYHRGNTGGGCLLTFGLQILVGINPTAALIQGTVKSVETLMAHTIVKIKSALDLQT
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFHGDEQNVATDVLASDSTRNKALRGKQLGVVSSFLNSFEHNQSFPMLPKNKKENRLAKGLNKFTGKEINACTFSQDHLANFNPADFPSVDLEKSFSSCISKSSSRPHSRLSLGGSWSFSSFINASDKINPSDIKPINKAVFTIDAETSQILTANTNACIMFGYNGGFVNVKLTNLLKKPSPGKPGKEALLRDIHDVEGNEVVIAGKVMEAVTKQGDVFAVSVWARKVEANTEQPRCLVILQPVVRVVGKFQFNQQGDILSCDDKFGHIHGYSDNTLLSKLKLQQLMPSYEMPTSSRISKGVRKQQVTSTTLDGQKIPILVYIINQTESDTDVIYSANVWYFTDINGILVCHPCGKIKQINTNFSLALMGYTASEMCNKNIRDVLPDISSSAEPCSIKLDISDDEVALVKACSEDRTPNEQFSATLIEKLSENETLQTSSCEPFEMISNATAGNQQVSSFTHIDFTLSEKQQSTADHINSLLSGSCSESLGSDVDHNGSNIPYKHDLEGNSSWVELTLNEGNPSNAKDKLSQINAALNGSLHSQPTVKDKTRSPDSAVHSSSETTESSSTQENKGSTKSSFSDYHSRDGSPAHVFKSSANTSQLANHPKPNALSKTINITSTPIDGLLRSESRMKSTLDLPLGIFSGQLRHKNNTLIPVTYEIQNDENGQLFYVRISFTTNYSHDPNQTLSSSFNSTLPSLNASAVSGMLDYSLGAAIKQAAEQRNGNVSHEIETPEGNEEWNAMQGKFKEYYDVIRTIGNGAFGFVRMAKRRIDGKKVIVKFIRKEKVLDDCWVDDYEREATIPLEISLLFKFNHPHIVEVVEFFENENFFSMIMPTHGTQGFDLFEFIDREPKLDEALASYIFRQVVSAVNYLHQQGVVHRDIKDENVIIDECFHCKLIDFGSAAFFEDGKKFSTFCGTIEYCSPEVLLGNSYKGPELEMWALGVTLYTLVFGENPFLTAEDTIEAILKPPNRLSDELMFIIQWLLQPVPEHRCTMYDLLEDPWLNIIIDPKEYNWEDVVPSAGQKDVSYNGAIKPKMDDDCVEDFDSDDNEPLANQVKCWVNEHKKFGLKHGKMDPSGLDKDENIFPLTRCLENINLNHSI
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MARPSRLYLLAYNSLQAIGWSVAFLRLLACLAPPVSVDSAYAAAGDLICLLQTCAVLETIHAAVGLVPTSPFLAFLQWGGRTHFVLALLRQIPEVQDSPSVFITFMAWSISEVIRYSHYALSTIKVCPAWLTYLRYTAFIPLYPIGVGPGEMWTMYQALPFVKERDLYSGFFAKFSMSYHSFLVGVLLCYPLLWLKLYLHVFKQRKSKLGKADRKKRA
The following text describes a protein:
Function:
As a component of tight junctions, plays a role in paracellular ion conductivity.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell junction, tight junction.
Sequence:
MEDPSGAREPRARPRERDPGRRPHPDQGRTHDRPRDRPGDPRRKRSSDGNRRRDGDRDPERDQERDGNRDRNRDRERERERERDPDRGPRRDTHRDAGPRAGEHGVWEKPRQSRTRDGARGLTWDAAAPPGPAPWEAPEPPQPQRKGDPGRRRPESEPPSERYLPSTPRPGREEVEYYQSEAEGLLECHKCKYLCTGRACCQMLEVLLNLLILACSSVSYSSTGGYTGITSLGGIYYYQFGGAYSGFDGADGEKAQQLDVQFYQLKLPMVTVAMACSGALTALCCLFVAMGVLRVPWHCPLLLVTEGLLDMLIAGGYIPALYFYFHYLSAAYGSPVCKERQALYQSKGYSGFGCSFHGADIGAGIFAALGIVVFALGAVLAIKGYRKVRKLKEKPAEMFEF
The following text describes a protein:
Function:
Acts as a cyclic nucleotide-gated ion channel. Permeable to potassium and sodium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Might constitute a common downstream component of the signaling pathways leading to hypersensitive response (HR).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.
Sequence:
MATEQEFTRASRFSRDSSSVGYYSEEDNTEEEDEEEEEMEEIEEEEEEEEEEDPRIGLTCGGRRNGSSNNNKWMMLGRILDPRSKWVREWNKVFLLVCATGLFVDPLFLYTLSVSDTCMCLLVDGWLALTVTALRSMTDLLHLWNIWIQFKIARRWPYPGGDSDGDTNKGGGTRGSTRVAPPYVKKNGFFFDLFVILPLPQVVLWVVIPSLLKRGSVTLVVSVLLVTFLFQYLPKIYHSIRHLRRNATLSGYIFGTVWWGIALNMIAYFVAAHAAGACWYLLGVQRSAKCLKEQCENTIGCDLRMLSCKEPVYYGTTVMVLDRARLAWAQNHQARSVCLDINTNYTYGAYQWTIQLVSSESRLEKILFPIFWGLMTLSTFGNLESTTEWSEVVFNIIVLTSGLLLVTMLIGNIKVFLHATTSKKQAMHLKMRNIEWWMKKRHLPIGFRQRVRNYERQRWAAMRGVDECEMVQNLPEGLRRDIKYHLCLDLVRQVPLFQHMDDLVLENICDRVKSLIFTKGETIQKEGDAVQRMLFVVRGHLQSSQLLRDGVKSCCMLGPGNFSGDELLSWCLRRPFVERLPPSSSTLVTLETTEAFGLDAEDVKYVTQHFRYTFVNEKVKRSARYYSPGWRTWAAVAVQLAWRRYKHRLTLTSLSFIRPRRPLSRCASLGEDKLRLYAAILTSPKPNPDDFDDY
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
QVMSEASIGVVSPKACDVCNSVAKMLLDYLNSGKSIQALIKLLQGVCAFFKLAGPETCNGAIDLYKDEVIYIMRNLKAPPHELCTVVMGSSCGPLASPVHNWTVPLNGRPKPAVDARTGRGLTRHLRVLHVSDTHYDPEYEPGSNGDCPEPMCCRGANGKAPSDETKAGKWGYLGKCDIPLRTLESMLQHASQNHKASGARIDMILWTGDLPPHDPWKATKEETISNLRVTSQLIRKYFPTATVLPAIGNHEAVPINSFPVPNKGNYTVQWLYDEFANHWMDFLPQSTKPTIKRGAFYSIQAGKGLRVISLNTNLCYIYNWWLLYNSTDPKGQLHWLVDELQRAEDAGDKVFIMGHVAPVHLECITAWANSFRRIANRYESTIVAHFYGHTHFDHFHLFYDEKDESRPTGVAYMGPSVTTFVETNPSYRVYTVDGVGDKPSWEVVDHETYWMDLAATNRDDKPRWALQYAAKKHYGLKSLSPRHWHELAERFNKDDNLFQDYYR
The following text describes a protein:
Function:
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVPAYWKPREPKNALTCDPPVPYDLQSSYQWQSILEHDTCYAAEVFDKMMIELVYHPERTSSVIMRTDIILDSQEDDSILNKQKSVFENLDERYQISRWIDRRIIPRNTNLDATMDQTVVVLHEKLENDRILMYLPHLDKSLEQPYNHLPYYHPAVAGIAFHYKGSSVEVLYLVEKDFQRELSSRLLRTAHMLLLVLHKHCKGAVEGYQKRMLHDTVVERNKFQDTYVILKDKYAKQLVDNWVEKTDPGKHVFEDLAIAAFLIELWKQTYSSNKEFSFVDVGCGNGLLVYLLLMEGYNGYGFDARKRKSWETYPLWVQVKLYEKVLVPYFLHDFETKIPFPQLPAGFTMSAANIHDGRFSENSFLIGNHADELTPYLPILARLNQKCYFMSIPCCVHDLTGAKISWALPKPRNPKHGGRYAMYIEWLMQLSEEVGWNIEVEPLRIPSTRNYALIGRKLLSNDLLHSSLSTDALYDIVEKNHGSQGFFVHAMQVAAANSRSH
The following text describes a protein:
Function:
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEANQSHNAKTNHPTCLTIAGSDCSGAAGIQADLKVMTAHQVYGMSVLTALTCQNSHGITGIYPLHPSLIQRQIDACLSDIQCRVVKIGMLPDPKSIPVISQALTKYKITDVVMDSVIISSMGNVMCETPTIPATIQHLFPHLLVYASNVMEAFILVEKTLKKSPPPLKSFPDIQNLMSIIHRLGPKFVVLRGHHVAFDKNMMITEKPDSKSWTADLIYDGKEFYIFEKPYNTTKSIHGESCSLTAAIASNLACNIPPLQAIHEALYSIEWAIQRVHKKSSDPYKSAQLFTALGHSSKFSGSLISLKSENYIPQADLTSVLLSHIPS
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Miscellaneous:
MISCELLANEOUS: Present with 6440 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MELILNSLISDDLTEEQKRLSLDFLQDILQSNTKDYESYFSSRAVPGSITEDIAEIDAELSALDRKIRKTLLDNTSQIIGNILENDDRAQLDDIAKSLEQLWELDTNINKAADRNVTNDDINNESVSIDDFLEDDKEDNDTGRIMTTESNNLARKKKEDEFHKALSRLRNRISTKEDDKDDIRSDTLVTVLENLDSITDLMELPFLARTCIRTGHYQEAVMLYTHTTSLRSRFPGSTIVDEVCEKVLNEISTTMLSGLVKLLSTNVSVNSLKKILQYLNSIPPFDGKTNKSLLSVFLAMRYKFITDEIASYPLDVESSNESLIEMMVKRKIEVLREHVYMSLNVFLKSFLYDTNDLEIPFPEELESTVLRINGTNEEKEIEEKEKETKKEEYQKQDSVANNEEDVTENKSIEDVQEEVQGKVEGEDDGAERKTENEIENETVNKTEDKAEKEKEEEVNTKDNKAEKEEEEINKVEVTPEEPSKSIDNKAEKEEEEINKVEVTPEEPSKKIRTSKRENKIPTNAVMLQFVDKCITYVLKDLTRGLNSIKLSDSVCLQLVYCSFRLCDLNRNYHHLFLKKINDTSLFTTEQLARAIDKRAELASKYIYS
The following text describes a protein:
Function:
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein.
Sequence:
MREAWRLFPETHTVFVRQRRRSSDVTESRGRACAATIKPRRSGGGNKRTEPDRRQSKSSTDLINMVKITFQPVSAQKPEKDNDPDKITLPQPYEKVIPHVKPGQVIPSRKPFPIGLCCLAFGLLVFLTGLVLASVYTYRHYFIPQHIPEDSLFHCRVIYEDSIFAPLRGRQELEENVGIYIEDNYEQISVPVPHFGGSDPADIVHDFQRGLTAYFDIALDKCYITELNTTLVMPPRSLWELLINVKRGTYLPQTYIIQEEMTVTGRVRNMRQLGPFIHRLCFGKETYRLRRRNQRQRIERRETKRCHKIRHFENTFVVETVICDRF
The following text describes a protein:
Function:
RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Subcellular Localization:
Cytoplasm, Stress granule. Cytoplasm, cytosol. Note=Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment.
Sequence:
MLLFVEVTSKGTGLNPNAKVWQEIPSGNPDGTPVTEPSWHETAATSGSHPEGHTELSEDMCKEYEVMYSPSCETTRNTADVEESADGMILGPEDLSYQLYDVSGESSSAISTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTNTDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPVEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYTQPIQTPTQYPSPVFMQPVYNPQQYSVYSLVPQSWSPSPAPYFETPLAPFPNGSFVDGFSSPGSYKTNAAAMNMGRPFPKNRVKPHFRSSSGSEHSTEGSVSLGDGPLSRSSSRIFLSERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRRRDDDRIPRPQPAATEAKAPTPKFDLLATNFPPLPGSSSRVPDELGLENRMSDVVKGVCREKDSEDVRVSCPVPAEDGQTDCTSAPLSISPSPPCTAEPPVLSTTQQEQDQMEDSAVPKDTLNPVAVPVSSPTATKPSPANTASPCTSNINPPRAVALQEPRKLSYAEVCQKPPKEPSPVLVQPLRELRSNAVSPTRNEENGAPEKPVEKPHEKPETRASKDHSGFRGNTIPRGAAGKIREQRRQFSHRATPQGVTRRNGKEQYVPPRSPK
The following text describes a protein:
Function:
Binds the viral DNA inside the capsid and the portal protein. May control the DNA exit from the virion.
Subcellular Localization:
Virion. Note=Probably located next to the portal vertex. Present in one to two copies per virion.
Sequence:
MPEPQNQEELDKYLDNIITQAEKRLDKVFASRLKEIKAMINKLFEKYSKNGELTYADVVKYNRLEKEMDVIKQNISADYKTVLKMLNELLETQYVDNYLRSAYIYEMYTGRNLGFSVPSADVVQRAVENPIPLLTLPKVLERQRVELINNIAMAIAQGLMAGEGYSQVAQRVHKRMQLSLAKARLTARTEGHRVQVAGRMASAEQAAKKVNMQKMWSAALDTRTRAGHRKLDGKIINMDENFKSIYGGVGKAPGHMHMAKDDCNCRCALIYVIDGEIPSVRRARLSDGSTRVIKYIPYTEWEKQKKAS
The following text describes a protein:
Function:
Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRKEDFLSAKQVHTRPLSKYCDYDIENCTTKSFAPNHSKYHREMASSPVPATCKVILAQGIAKKLLGEVSTDLKKLSFKPKLVGLLANDDPAAQQYADWSMATCIENGFDFELRKFTKEEIEDEILKANNDDSIHGIIVYYPIFPAPSLQDGYIQQIVALNKDVEGLAHTYRFNMYQNIRFLDAPHNTQKSILPCTPLAVVKVLEHLQIYNSVLPYGNRLYGKTITVFNRSEVVGRPLAALLANDGATVYSCDLDGVKLFTRGKGIKKVHHEVHDMEGMKNDDCLPKSDVVISGVPGERFKVNTELIRDGAVCINFSSQKNFDGPAVKEKASIYVPSIGKVTIAVLLRNLLRLVENQGKGAAKPTEISN
The following text describes a protein:
Function:
Involved in transport of proteins into the mitochondrion.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MSLVAEAFVSQIAATEPWPENATLYQQLRGEQILLSDNAASLAVQTFLQMCNLPVKVVCRANAEYMSPSGKVPFIHVGNQVVSELGPIIQFVKAKGHSLSDGLDEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITLARYGSPYPWPLNLILTYQKQCEVKRKMKAIGWGNKTLDQVLEDVDRCCQALSQRLGTQPYFFDKQLTGAAEPQFGAGSRMGIEKDGELKKKISASGRWRCPPLIPALGRQRRADLCEFKAGLICTVNSRTSRATQRSPAQQQQQQQQQKQKQQQQKQQQQQQQQQSGGGG
The following text describes a protein:
Function:
May be involved in assembly and disassembly of the actin cytoskeleton.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDDSVPPPSYEEVLRQEGVIDSPNSSNGQTSTSAGHPSSSSSTLPNYAASSLNSRPVSSSGSGNAYSQAPYPPARPTSQRPNSWQPGNASTMYASPPPSSNYNTAKPPYQTSQFYARPQSSYAPPPSGRPRISYPYPPGYMCYKCHNTGYKDSGRPCGRCARRFGRSYDVQFSRPPPGALVVYPGDPRIPGRVCGNCKGSGQLDFIFFTEICPVCNGVGKIPY
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MATRSVRELEKQIEELRYEANTERVKVSQSCKELMDYCESHASQDYFLYKTDKTNPFKESRSPCVVL