lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and a low-spin heme of subunit 1 to the bimetallic center formed by a high-spin heme and copper B.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVDVPYDRIADIPPAEVPDVELYHPRSWWTRYVFSQDAKVIAIQYSLTASAIGLVALVLSWLMRLQLGFPGTFSFIDANQYLQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYVNMLSYWVYLLAVLVLASAFFVPGGPTGAGWTLYPPQAILSGTPGQDWGIVLMLSSLILFIIGFTMGGLNYVVTVLQARTRGMTLMRLPLTVWGIFTATVMALLAFPALFVGSVMLLLDRLLGTSFFMPTLVEMGQLSKYGGGSPLLFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVAIGALSFVVWAHHMYVSGMYPYFGFFFATTTLIIAIPTAIKVYNWVLTLWHGDIHLTVPMLFALGFIITFVNGGLTGLFLGNVVVDVPLSDTMFVVAHFHMVMGVAPIMVVLGAIYHWYPKVTGRMLNDVLGKFHFWVTFLGAYLIFFPMHYLGLLGVPRRYFELGDAAFIPPSAHSLNAFITVVALTVGFAQMVFLFNLVWSLFEGEPSGGNPWRATTLEWQTPETPPGHGNWGKQLPIVYRWAYDYSVPGAAQDFIPQNQPPPTGAVQGVAP
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MTSESDERMIPINGADSPSTDDANSGGDGGLNGPLKKGPWTSAEDAILVQYVNKNGEGNWNAVQKHSGLARCGKSCRLRWANHLRPDLKKGAFTAEEERRIIELHAKMGNKWARMAAELPGRTDNEIKNYWNTRIKRRQRAGLPIYPPDICLQALNEGSQQNEDTINTFSPNDVHRPDFIQISTLDVPSLEFKGLEINQPLYPLDIPSNTLLDISTNTLLSQGLHPHPHPHNHPFYLHPPSKRLRSGAPESMFPCINIVPPIGMSQYQSNDGLLLSCPSSDPSAWAMKMELPSLQTQMRNTTANTNWGGPPPSPANNPFFEPADVLMQSPPPNEGAQLCNLSPQNSGLLNEVLYESGALNNSKTSYSFPQPDSYIDIDSSNANVLCDAEWEPYGERLSPLVHSLDDPHSDETKQPVKDEDDYLNPMQYNDKFETNPTIFSKPDFMYPSTSFDGPVKQHPMNDNYLLKDVIGTFLGDDFRDCKKMDTGATSSSQGHCHDSCAWNVMRTI
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity to ensure proper cell division. Required for the maintenance of plant architecture.
Subcellular Localization:
Chromosome, centromere. Note=Colocalizes with CENH3 at the centromere.
Sequence:
MGNASENFDIEDLMSYGDDLINLLNVKNGFDIISQSSEQFKALNFACHEDFNQIQGSIEDCKTKLYACKKKTEEAYSDIAAEDEIERLQKELDEEMEREFKLKDELRLVADELKDLNAQLSSIDEHKQSTKRKVRDDLRAEKKLSMYASVTNVIPDIDDPSKISGYMVDREKRLIEKFQFETNKMTAYETCNSIWSIINKQ
The following text describes a protein:
Function:
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MAYPSTISVTFSLLPRPSISHFANGHFNLQPPRRHPTASPARRWPERSLASQRPPPPPPPPPWTPLPAAAPASPRCAPSRTSSATSAPAAPPSSAPSPKVCDLFSRLAGADLDCLCLYGNSDGTWEVAPPPEMVPPELPEPALGINFSRDTMYRSDWVALLSVFSDSWLLAVAFFHGARLDRDDRVRLFNMINDLPTVYEVVFGVEQSDEQSGMDNGAKDTPSPQVKLNVYITVLPLC
The following text describes a protein:
Function:
Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Cytoplasm. Nucleus speckle.
Sequence:
MIPTGNKVDDSTGETSKQTGEDGIVKKKSGSKSKSGRSKTKSSKGTTGKRESRKHNDSARSGRRVDDERVVDANGSVSGVSTQGNSPVAGTAYPKQVATSSDDGRVKASQKSTNNVAQTVNEIHDVIIIQEEDDPRETYARQPTKVTVMKADGGEETAVVIDTSMLDDVNQPANVEVGKNGGMSDIVAASYNIATSNDVMDEQPQIGEHGDFDSRKKKNANNNSDESGHEMAGKEYTEMSDITLGQVQGSYTQAQDYVEYSQPQHTSYQSQPASNAGWYQHEQPVIQGQVVHDPSVASNVAYPSQNSSLGYTQSYNQHFGTAPGYIPQYAVGPGGQYFRTLPGGDGLRYEIVEPSTNLILGNPQMGIAGYRGSTSGGYGVVSPSVSTQPSGTYPPMEEWEEEGENDEEKIKEEKLAKRNKIKRPMNAFMVWARQKRTIYAKNNPGLNNADISVRLGERWNSMTAAQKQPYYDQADKIKADHKKEHPDWTYQPKPKRRRMGQGTTWLYAVTENTRGGRISRCIKTFEHCNGSLVFPHRETPSAEVPGTSSPQIGNVMTIPMPQVQPTHPMYGNQSIPPGSMTLPPHLAQRGALLTPGPNGPMFMQNQVGQPMIFGGAGLSQGQVHVLGAPPLYTQHSMLPTQEYSTEATQPRSNTAPSSRFMMMGGYPVIPPVANLVATSGVPQTKSSDLTEDARRVLDIGGNSTNENKAARLHEKTAGLNKPVLAGFSDPTLHTLRDFLQPGVADNQVHKSD
The following text describes a protein:
Function:
May dephosphorylate thiamine phosphates.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MQLCIISLWFLAAFIVNADNVQFEDYESNFFFKEHLGTLSPYHEPYFDGLDSAFPETCEIQQVHLLQRHGSRNPTGDVTATDVYSSQYLNNFQEKLLNGSIPVNFSYPENPLCFIKQWTPVIDAENADQLSSRGRLELFDLGRQLYQRYYKLFDSYVYDINTAEQERVVESAKWFTYGLFGDKMYEKTNFILISEGKAAGANSLSMYNACPVFKDNNFHKNATDAAHAVWRNIFIEPIVNRLAKYFDSSYKLTINDVRSLFYICEYEIAIKDHSDFCSIFTPSEFLNFEYDSDLDQAYGGGPVSEWASTLGGAYINNLADSLRNVTNPDFDRKVFLAFTHDSNIIPVEAALGFFPDITPQNPLPTDKNIYTYSQKTSSFVPFAGNLITELFFCSDSKYYVRHLVNQQVYPLIDCGYGPSGTSDGLCELQAYLNSPIRANSTSNGISIFNTECQARPTNVTIYF
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
GGFPEKKRRLSVEQVRSLELSFETENRLEPVRKMQLAQELGLQPRQVAVWFQNRRARWKTKQLEKDYDVLKAAYESLAEENKRLKAQ
The following text describes a protein:
Function:
Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Part of the ABC transporter complex PstSACB involved in phosphate import (Probable).
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MKFARSGAAVSLLAAGTLVLTACGGGTNSSSSGAGGTSGSVHCGGKKELHSSGSTAQENAMEQFVYAYVRSCPGYTLDYNANGSGAGVTQFLNNETDFAGSDVPLNPSTGQPDRSAERCGSPAWDLPTVFGPIAITYNIKGVSTLNLDGPTTAKIFNGTITVWNDPQIQALNSGTDLPPTPISVIFRSDKSGTSDNFQKYLDGASNGAWGKGASETFNGGVGVGASGNNGTSALLQTTDGSITYNEWSFAVGKQLNMAQIITSAGPDPVAITTESVGKTIAGAKIMGQGNDLVLDTSSFYRPTQPGSYPIVLATYEIVCSKYPDATTGTAVRAFMQAAIGPGQEGLDQYGSIPLPKSFQAKLAAAVNAIS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in the accumulation of the PSII complex.
Miscellaneous:
MISCELLANEOUS: PPIase activity is unaffected on reduction.
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MVTILSTPLSPRLTFLCETKLSLSRSNRSVCCSLSEEPKDQCLSRRSLVYVLVASPCLLLPALSSSAKTKSKSPYDERRLLEQNKRIQRENNAPDEFPNFVREGFEVKVLASDNYIKADSGLIYRDFNVGQGDFPKDGQQVTFHYIGYNESGRRIDSTYIQGSPARIRMGTNALVPGFEMGIRDMKPGGRRRIIIPPELGPPVGPSTFFSSKQFEVFDVELLSIQNCERRTIIGFYSDVTCS
The following text describes a protein:
Function:
A flexible structure which links the flagellar filament to the drive apparatus in the basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MAFNTSLSGINAANADLNVTSNNIANVNTTGFKESRAEFADMFQSTSYGLSRNAVGSGVRVSNVAQQFSQGNIDPTGRSLDLAISGEGFFAVSSNGAKMYTRAGNFQTDANGYVINPQGARLQVFAPNPSGNGFDVGRLSDLQLLTTDSPPKSTSTVNLAFTLPGNASAPTVTPFNPADDKTYSHSTGGINVYDSLGVSHVQTSYFVKTANPNEWQVHNYVDGSAVGAPTTLQFSDTGSLTTPANGIVAMDPFTPSTGAGVLSMQLNVSGSTQYGEAFALRDTRQDGYASGKLNEISIDTSGVVFARYSNGADKALGQVALNSFVNPQGLQSQGNNMWAESYTSGAARVGAPDTSDLGQIESGSLEASTVDLTEQLVNMIVAQRNFQANSQMISTQDQVTQTIINIR
The following text describes a protein:
Function:
Probable circularly permuted 1,3-beta-glucanase involved in cell wall modification through beta-1,3-glucan network alterations such as increased branching or remodeling.
Miscellaneous:
MISCELLANEOUS: Present with 5525 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=GPI-anchored plasma membrane protein (GPI-PMP).
Domain:
The conserved ExDxxE motif might be important for catalytic activity.
Sequence:
MLQSIVLSVCMFMLHTVAASGPQSYQKLDFTNVGFTGSYVDVNKFKDITNNESCTCEVGDRVWFSGKNAPLADYLSVHFRGPLKLKQFAFYTSPGFTVNNSRSSSDWNRLAYYESSSKTADNVTFLNHGGEASPCLGNALSYASSNGTGSASEATVLADGTLISSDQEYIIYSNVSCPKSGYDKGCGVYRSGIPAYYGYGGTTKMFLFEFEMPTETEKNSSSIGYYDLPAIWLLNDHIARTSQYPTNANCSCWASGCGEYDIFEAMNGTEKNHLYSTFHTFQGIEDLGTGIQSYGYITRNTTGTMKGGVVFDSSGNVVSFISDATPFNGTVSADTVNDLLAAIPENETYSSQLMSISATAPSTTSKSNGVALTKMQNGVWYYILAIFTAFTQVVLI
The following text describes a protein:
Function:
Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Acts partially redundantly with cdk-11.1 to ensure embryonic viability. In contrast to cdk-11.1, not essential for male and female fertility.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Evenly distributed between the cytoplasm and nucleus in embryos, but becomes more enriched in the nucleus from the 4- and 6-cell stage as embryos develop. In the germline, localizes to the nucleus and cytoplasm in the mitotic region, but is enriched in the cytoplasm. Nuclear localization increases as cells enter late pachytene, and then the distribution between the cytoplasm and nucleus becomes more even as oocytes mature.
Sequence:
MSNYSTNGSRKIRISNSDDDSRETRFSIQPRNSHKTKEERYRDKEKERDHERHHDRERRDDRYRKVDSRDHRDRNRRSPAGSRTYCRDEPDRRRNNHSDRNRRDRSSERDRDNRSSKSKTKSPDSLRSKSSRKSQTPNHLPDDGKLFDRILDPNYKKKEKTVMEVEDVEMSPVEMLDEEEVSTFTFDDACGPVRPSNEPEEKDYKSEGDPESRPATPKTPLTPDYLENTIVSLNETLSDDEDKGPDDKYGKTPDKEQWESMTENEQKLHRDAMKKRREQRHREAVSKLPVYYPGLRGCQHISEYVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINMLLKAGAHENIVNVKEILVGSTKTEVYMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLSGIEHMHKLWILHRDLKTSNLLISHSGILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRSPELLLEPKTYSTPVDMWSIGCIMAEFIMMKPMFQGDSEPNQVHQIFQMMGTPTEQIWPDIKELKVWNMVEFPPVKPGQLRRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQHDWFSEHPKAVPPEDLPVYPAKSELNAAPPENRRKNRLEALLADEEPERAALLRQFNVKAEQLKPSGFQLRG
The following text describes a protein:
Function:
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Subcellular Localization:
Cytoplasm.
Sequence:
MIELVTDSPHPIHLVDSLQNPKLFASLSTDFPLIFITNTKLNALILPPLLDLARSLGFSVETLTIPEGEETKTGDTFLSLHQQLTDLNVPRQATLIGVGGGVILDIAGFVAATHCRGMPFIAIPTTLVAMIDASIGGKNGINLNHIKNRIGSFYLPKAVWICPRKLSFLPQQELHHGIAECIKHAYIADSAILPLLQDPNALKKEDKLSLLIKKNCLCKASVVQQDVRDYAKRQILNFGHTLGHALEMLFIGKIPHSCAISVGMVLETKLSLSLGVARSPAILHSLIQDLLRYQLPVSLKDLYMRAQIPPHNCDQILSALTYDKKKQNTPLPPFVMIEEIGLAASFDGRFCQTISKHILTKVLEEEFYAMHNN
The following text describes a protein:
Function:
Has a role in the perception of gravity.
Sequence:
DQLSRTNLYIRGLTPNTTDKDLEELCRKFGTIISTKAILDKNTNKCKGYGFVDFDSPSAAESAVKALQLQGIQAQMAKQQEQDPTNLYLANLPAHITEQDLHDMLYKYGTVISTRVLRDGGSQSRGVGFARMESREKCDEIISIFNGKLLSGSTQPLLVKFADGGNKNKRQHKTHDQRWRDAADGPGGLLSAYD
The following text describes a protein:
Function:
May be involved in zinc transport from the cytoplasm to either intracellular organelles or extracellular spaces.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYNKNNNNNNIIDDNDYDDDDDDYNYYNNNNYDYNENLISKDTKKQKDLEKEPLSKSIAFISIGTLTLLYVIVELGAALYVGSLTLLSDGFHNLSDVVSLVIAWWAQKAAKRDSDNFMSYGWARAEILGGLTNGCFLLSMSLYVALEAIPRFIRPEPMESGLIFMIVAGSGLAINILGTIVFACTGMSHAHSHGGGGHSHGGGGGHSHGAEKEKKKEKHGHSHDGADKEKKKEKHGHGHSHSTATTAVGINSEEHNHDDHDHHDHSEESHGHSHGGEKKKEKKHGHSHSHGGGAAEGININDEHDHDHEGHHDHSEENHGHSHGGSEKKKEKHGHGHSHDGGVEKKKEKHGHSHDGVEKKKKKKKSSGTCLGMDLNMFGVFLHFLGDAISSLFVLITGAVIHFTHGKWTEYIDPAVSLIIVIMIAATSAPLVKRCSMILLQKVPDDIDLDSIRYKIAKVEGVVSQHDLHVWQLVDGMTIASVHVGIEQGREFQSIASKLRKIFHKEGIHSTSIQPEFLPINSFTGGATSDPNFCIQNCVDDCEEEWCCKKSADRIRMRNFNSKNSNIVDINDI
The following text describes a protein:
Function:
Catalyzes the Claisen rearrangement of chorismate to prephenate. May sequester with cyclohexadienyl dehydratase and an aromatic aminotransferase to form phenylalanine or phenylpyruvate.
Subcellular Localization:
Periplasm.
Sequence:
MTHFVAIFFSSLFMCSNVFAGSVSSVSLGSLSSALNERMQVMKAVAGYKALHHLPIEDLPREQVVLDHMLQNAQQAGLEPHSVEPFVHALMNASKTIQYRYRADWLSSPDSAVPVRDLTETRQQIQQLDTQLLTAISQRLMTGAFSQEDKEFLMSHLTAPHLSESDKNSLFASLSRIQRQH
The following text describes a protein:
Function:
This is a receptor for the anterior pituitary hormone prolactin.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MNWRIQDTMRDAEQVLTLVWLLCGIPHSMCHSPPGRPRLTRCRSPEKETFSCWWETGSSGGLPTRYQLYYRKENSLEVFECPDYHKAGINSCHFEKRHTAIWIIYNITVVASNALGKAYSEPVEVDVMDIVQPHPPESVNVSLMQSQNSQYVLVKWLPPHDVDTRSGWVTIKYEVRSKILNSRDEEDSSWESYSAGKQLEFSIYSPHPGTNYVVDVRCKLDQGLWSDWSPSVFIQIPDNMTVMQNTVVICAVTLTVVIFMLTAGVMTFKKTQVKHFLLPPVPEPKISGLNTQLLKSGRSEEIFSALITPGLYPQISQSTDHQVEYLVVSDCDEEMTVGKAHFEIHKAEICLIDATESSKGNGVVFGEPQKPLHLNCSVTAHDRNTGMSSECKCEHVDITSAGPTGYVEVDREQPDQKDYSVVSDVINDNMLVLQDSIPVQEHKEVKCKKKYVLN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that negatively regulates water stress response. May control in coordination with PUB23 a drought signaling pathway by ubiquitinating cytosolic RPN12a. Acts as a negative regulator of the immunity triggered by the pathogen-associated molecular patterns (PAMPs), in association with PUB22 and PUB24.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGGIMDEEIEIPPFFLCPISLEIMKDPVIVSTGITYDRDSIEKWLFAGKKNSCPVTKQDITDADLTPNHTLRRLIQSWCTLNASYGVERIPTPRPPICKSEIEKLIRDSASSHENQVKCLKRLRQIVSENATNKRCLEAAGVPEFLANIVSNDSENGSLTDEALNLLYHLETSETVLKNLLNNKKDNNIVKSLTKIMQRGMYESRVYATLLLKNILEVADPMQSMTLKPEVFTEVVQILDDRISQKATKAAMHILVNICPWGRNRHKAVEAGVISVIIELLMDESFTSERRGPEMAMVVLDLLCQCAEGRAEFLNHGAAIAVVCKKILRVSQTASDRAVRVLLSVGRFCATPALLHEMLQLGVVAKLCLVLQVSCGGKTKEKAKELLKLHARVWKDSPCLPKNMILAYPC
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPSDKAAYLAAHYLSTDPPNKSSSSTSKKRKRKNKSAEDGLIIADDDDTSWAQAAKRDSDDDDFDGPVLAAGVVSADFRKAKKSGWKTVGSSSAFAKQATTSTTTNSTKEDIDAAAAADAILAQTAAETAALAREAGGDDEVLVVDTTTGATALTRSHQPAETATQAPIMSNGTHAGLQSASAITAQLKARQEAERLELERIRAERDQQHPEDQEELVLRDATGRRIDASMRRAEARRQQAEAERKEAEKKRALKGEVQLEQARRRREELEEAKLMPLARSKDDEQLNAELKQQDRWNDPMAQFLAPEEVKVKGRKKGTAGRRPTYKGPAPPNRYGIKPGYRWDGVDRSNGFEAERFKALNRRERNKGLEYAWQMDE
The following text describes a protein:
Function:
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
Subcellular Localization:
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Sequence:
MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDDDVEEDEGVGEVRVHRVNHAPGQSQEHDAPRQSPQHQYQPPYASAQPRPAAPPQPQAPMQQPVQQPVQPAPQPQQVQPSAPPVQPPQQQPAPPSQAPQPVAQPAPPPSAQTFQPAEPVVEAEPVVEEAPVVEKPQRKEAVIIMNVAAHHGSELNGEVLLNSIQQSGFKFGDMNIFHRHLSPDGSGPALFSLANMVNPGTFDPEMTDFTTPGVTIFMQVPSYGDALQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDRIREVMDANA
The following text describes a protein:
Function:
Transcription repressor.
Subcellular Localization:
Nucleus.
Sequence:
MEEYEAQLLVVEQALENAADDAQRQDLLALKNNLQELLALTRESGDEAPIDELPQQGDNLDDELQRLKSELNDLEAAGSSQTALDEERQLADLRTKYTAMVGEKCSAPHEHSWGTCYHNALICGVDDEVVMNSEGVLDARLRVLFTNPTHREMLPCSYYLEGECRFDEAKCRFSHGALVTGSSIRKYNPPDFHKLSRSRPVFALLPDRLWHRGRVLCVNFVEQICRVRLDGQDHKERERDFKFEELYPLTTDQDEDDELSSEESNSSMNDNSSDEAESDMDDLEEARRARMVELSLFTFKPTERLGAWEEFTRGIGSKLMEKMGYIHGTGLGSDGRGIVTPVSAQILPQGRSLDACMELREAANGDKDYFSVERKLKRAQRRQRKADEKAYVRESQRVDVFTFLNDSVLGPGESTQQGEQVTKKAKTNELQQHSTKTLNVETVRIADEIRRKQRDMAKVKQSLDRNSGDAQLQKRLQVQMQSHKQELATLQAQERSLSKEQQTRKSKNKMFEF
The following text describes a protein:
Function:
Inhibits antiviral activity induced by type I interferons. Does not block signal transduction of IFN, but is important to counter the host antiviral state induced by a pre-treatment with IFN. Plays a role in the inhibition of host NF-kappa-B activation by preventing the acetylation of the RELA/p65 subunit of NF-kappaB.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MDLSRINTWKSKQLKSFLSSKDAFKADVHGHSALYYAIADNNVRLVCTLLNAGALKNLLENEFPLHQAATLEDTKIVKILLFSGLDDSQFDDKGNTALYYAVDSGNMQTVKLFVKKNWRLMFYGKTGWKTSFYHAVMLNDVSIVSYFLSEIPSTFDLAILLSCIHITIKNGHVDMMILLLDYMTSTNTNNSLLFIPDIKLAIDNKDIEMLQALFKYDINIYSANLENVLLDDAEIAKMIIEKHVEYKSDSYTKDLDIVKNNKLDEIISKNKELRLMYVNCVKKN
The following text describes a protein:
Function:
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Translocates to the nucleus upon NOD2 stimulation.
Sequence:
MLQMPKLNEIPPGRGGPGEPWGEGRWAGPTGPEAARPARGARGQARGARARWDSWEHSRLPTHPGPGWDQCSPSFLCAPSSQKLIMESKDEVSDSDSGIILQSGPDSPVSPMKELTNAVRKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDEWALHREDPLSSLERQLALQLQITEAARRLCAEENLSRQARRQRKHAALQEEKKLRDLQRCLGDRRRNSEPPPTTVPSLGRELSASDDSSLSDGLLLEEEDSQAPKPPPESPAPPSRPLPPQSLEGLQPTGPESGGQERAPIQNSPWKETSLDHPYEKPRKSSELSSESSSPATTPQDQPNPSSLWVLDAASYHVVPIRNVPGQRQGRTSAPATPEMQGRRGQSQSLRVDSFRAGAEGRGRSAFPRRRPTHYTVTVPDSCFTPGKPPLPHPACHSCSEDSGSDVSSISHPTSPGSSSPDISFLRPLCLPEPPRHRGAWGPACGRELAPHYSKLLLPAGYFPTGRYVMVAEGHLPPGEWELCRAAVGAAYDEEGAPLRYQRLVPSHSRIVRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSSRPHSLDRQGAFRVRSLPPGRESFGRASGPRTQVPPVYVLRRSTDGAPVQVFVPENGEIISQV
The following text describes a protein:
Function:
Probable oxidoreductase.
Sequence:
MAAQESIFAGLIPTVADITNNLPSLQFESALTDGEKPLLVLRARSHALTVCACAQAAYLVAILNEARQLVVELQTPVSRHSRSSRLLHQAPPRNPVRVGIIGGGRLGGQLAQALLTYGDVEPHEMVISTRRPEILVKLEEQGVTCLYDNRRVAASCDVLFLCCLPSQLNVVAEDIKGRIAAHCTVYSFVIGVPLPRFKQIFRFSNVLKPELSWRDDGQASWDVSKDVCSCLEDSRVASLTCPLPPQPDECLIRTGEKWAELAVYIFLNMCSDLQLSWEQSLDLANTVILGQTSTHPAAAAFSTENFTKNIANPAAPFPRFDLSLVTENDTPLTRCLKENQGVRNLFCKKYVSIFDKFYYWKGIKQVKQKKQ
The following text describes a protein:
Function:
May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
Subcellular Localization:
Golgi apparatus lumen. Secreted, extracellular space, extracellular matrix. Zymogen granule lumen.
Sequence:
MLTVALLALLCASASGNAIQARSSSYSGEYGGGGGKRFSHSGNQLDGPITALRVRVNTYYIVGLQVRYGKVWSDYVGGSNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVTDKGRYLSFGKDSGTSFNAVPLHPNTVLRFISGRSGSLIDAIGLHWDVYPSSCSRC
The following text describes a protein:
Function:
Protein phosphatase that specifically mediates dephosphorylation of 'Ser-586' of Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-586' of Akt1 triggers apoptosis and suppression of tumor growth.
Sequence:
MLKATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAKPRPKFHGGTVKRSAGPNSAYFGSLQRLMPYNFEYDFAVTQERERNILDEEEHDDDDFNEHESRMRKYWGVATTEL
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Subcellular Localization:
Cytoplasm.
Sequence:
MASVREVSSFTEDLLCPICLSIFRDPHMLECGHSFCASCLEPCIPKGQRRGLCPECRRPFALRHMAINRALCSLAEKARLLKLDEGPQLGATGGWYFCEEHEEPLKLFCSQDEGPVCVICRDLPQHRGHDFLPIKNAVQAYQDQLKASLEPLEEGLRRLKMSQCRQQENIIELKTCSESLSDHVSGEFVKMHQLLNDRELGLKEALENQREKNLTQMETKLKELNEKVASWSETLYQVRAGLQCKDHISFLKEAKDLLERKSVKKLYGRALLLTSFLIPSDLNLGEFKGPLQFFAWKELLGAVHPVPACITLDCNSAHPSLVLVEEATGVKFSPGRRFWRRKPERFTASPCVVGRKGFTSGRFYWEIRVGDSTGWVVGAAKKSVKRKRRLNFQPKEGVWAIELRAGQYQALSEPRTPLSVCGRMDKVGVYLDCEGGQLSFYNSSSMNHLYTFQESFHEELLPFLSTQGNHPLSVWDLEL
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAVFLRRSALYRAFNLNKSLRLSCVNISTTKKNKEVPSTTISDTGVSKPPVTAADFADTKPRYWMSYGYSETDYTMDRDYHHLVMFFGVTFMLGLGFIMMYIPDFRDLDWTEREAYLRLERREKLGLPKIDRNLVDPSRLTLPSEEELEGVEIIL
The following text describes a protein:
Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSQESSYGKWTISSSDDSEDEKPKPVKPSTSSGPQAGQGVSKEPTYTCSEARKAAHKRQISPVKFNNTDSVLPHKKQKMDSPEGLGWCLSSSDDEQQPDVTQQEQPKGVPPQEKKYAPSANVTTAQKVEDRSPPDSHRAQRADEEYETSGEGQDIWDMLDKENPFQFYLTRVSGIKAKYNSKALHIKDILSPLFGTLVSSAQFNYCFDVNWLIKQYPPEFRKKPILLVHGDKREAKADLHAQAKPYANISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIYQGNHTSGESSTHFKADLTSYLMAYNAPPLQEWIDIIQEHDLSETNVYLIGSTPGRFQGSHKDNWGHFRLRKLLQAHAPSAPRGECWPVVGQFSSIGSLGPDESKWLCSEFKESLLAVREEGRTPGRSAVPLHLIYPSVENVRTSLEGYPAGGSLPYGIQTAEKQRWLHPYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKLAWFLVTSANLSKAAWGALEKNGAQLMIRSYELGVLFLPSAFGLDTFKVKQKFFSSSSEPMASFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRALLEEL