lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFGKEFATQMVPEWQQAYMDYDYLKSLLKEIQRSKQRHKPPPVATTPRSHRLKRRLTLYRAFSGLTSQSRHSQQQPNSPSSISPVDIESQAILVNSVRSDGSESYQTTFLMAAEEGGVQELEYFRKVDDEFNKVDKFYRSKVDEVMKEAAVLNKQMDAFIAFRIKVENPQRPFDWSVEMTRLASDVAASTAALAASTPRGVRASRRAAMAMDVIEESGSNSQEEHSGDEEKDVKMTENVKIQEKKTENFRDTRPAPLDILNYVTMNHTVETPRSTIKGFLNVPPQTELKFSRDNLKKVEEQLKGAFIEFYRKLRLLKSYGFLNTLAFSKIMKKYDKITSRDTSKPYMNMVDNSYLGSSEEVTKLMERVETTFIKHFSNSNRRKGMAVLRPKAKIERHRITFAMGCFAGCTAALILALILMVRARNINNANNPEFDKGKTQYMDNMFPLYSLFGFIFLHMLMYAGNIYFWRRFRVNYSFIFGFKQGTELGYREVLLLSFGLAVLALASVLSNLDMEMDPKTKDYKALTELLPLFLVLLVVLILLCPFNLIYRSSRYFFLVCLFHCICAPLYKVTLPDFFLADQLTSQVQAIRSLQFYVCYYGWGDYKLRQNTCKSHDVFNTFTFIVACIPYWSRLLQCLRRLVEEKDPMQGYNGLKYFFTIVAVSMRTAYNLESLKNEVNWKILAGVFSIVAAIYGTYWDLVVDWGLLQRNSKNRWLRDKLLIPYKSVYYGAMVLNVLLRFAWLQTVLGFDVSFMHGQTMVAVVASLEIIRRGIWSFFRLENEHLNNVGKYRAFKSVPLPFNYDEDQDKHE
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12 (RPL12A/RPL12B) at 'Arg-67'.
Miscellaneous:
MISCELLANEOUS: Present with 1600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Appears often very close to the nuclear membrane and the nuclear pores.
Sequence:
MSELHALLTFPERPISQSYYVPKLQHFLKSGIPATYTLEQVAAFEHEEKNRNGDKEFRESTDDNKTSNTTPLHVLARSLPLDIKDEELQVVMDMMNILFEYGAGWNFIDYEDKTVGDLFLERNQSRESPLYRRLVEAGVSAELLLRKLNGGDVEFLDTDELIGIEPEESVQTAVDGQKEESVGSDDDATAANQQVYLKTELEYKDDALITKENKDGVMMDWETKIMELASETLFPDPEATNSATILNIGFGMGIIDTFIQARKPYRHYICEAHPDVLAKMKMDGWYEKDNVVILEGRWQDTLNNLLDKGEVFFDGIYYDTFSEHYQDILDLYDVVVGLIKPEGVFSFFNGLGADRSLCYDVYKEIVEIDVATYGMKCDYTRYSLDEQLPDWNDVKRSYFNCNYYYHPRITFA
The following text describes a protein:
Function:
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLELQDFYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMRKRNQKTMVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFDSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENKLEENEMINLTLQPFKKSGPQVKLSSSHKWSYSFIRKHRRRYSKKTACVLPAPARPPQENHSRMLPENFGSVRSQHSSSSKFIPGVPTCFEVKPEENSDVHDMRVNRSIMRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLISLIQCLHMS
The following text describes a protein:
Function:
Is probably involved in a pathway contributing to genomic integrity.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIEALEIVLLLVIQSLQYICRTCIAFLLIPFLGLYAFDLFLYVYRMILYLSQMFNYKRKLGRSKTNNRPHSPRLHKIYSSGDCMDTLIGQVRDLRVFLLSTIHSHSKRFFSTRFQTKSGINSAIDANDVETTSDVSSFTNLHLTRSSEEGYYIAGSI
The following text describes a protein:
Function:
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex. Acts as a competitive binder for CBF5 probably required to prevent non-cognate RNAs from being loaded during transport of the particle by inducing a non-productive conformation of CBF5.
Subcellular Localization:
Nucleus.
Sequence:
MRWASVAAALRSASDIGRMALEDSEATHSTTGVQPDDATGPDREAQGAESSSTAAPEHIHTQNADGTQPGEGSAALVADGETVAAGLRAGAQWADETVTVELPEDVSEADCLSSDEEGLGATPAAAAMQTSAEQGGSDGGSAEQGGSDDSSSESSADEADAALSDAELDEEEDAPQGPVRSKNELVEEPLPEIPADFVVESDTPILEIGTIKSAFDQNIIVQAMLSGEQRVLQEGSIFCLADRTVVGPVCEVFGKLSNPFYRVTFPKDAAEKFELFKNQLGAQVFLVQPKAHWLDTFEIKQVRGTDASNGVDEEVPEDEQEFSDDEAEAEFKRQKKLAKKRKAGNQDEKPRGKLSLEGRTGLPRMQVPSSLARASDRAPTYKPRSARQQRPVPPSHSRPQDQRASVAQPAHSAVPYAPLAAQPAPPVSYSQTAFPQATQPQMYPTSDPMAAPNQWYHNAAMQQVFHPAMMPQQYNPQQYAPPHFPQQYAGTYLPPQQYQEQLAPQPPVGQYNQAQLLQQLLLQQHNQNQQQQNQQNQQNQYPYPYNYQQHQPPH
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.
Subcellular Localization:
Nucleus. Cell membrane. Cytoplasmic vesicle. Cytoplasm, perinuclear region.
Sequence:
MDTEEVKRGRGRGRGTRARGRGRGRGRGRGKKIDDSSIADAAALAASSCAALEDSPGRLDASEDSVMQELDKDGELETPGALEEPLPHGALGAVAASGNMTPATQQPQVLQQVPPPVMSQTTISLSLARAVDMEADISQLEAPTFTTLSRGPPEPMLRLKWNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRHVAPQPPPLQPQPQLSAMAEQPKMTDLGGVGLGLELHKQRKLSESSVPISVSASIASRPVLSRLPLTGGVGNIGSIGSIPPPGSAAAAQNAIHGGHSTLTLANLTRINNANAQECHQGKASLHHTLKKGTPHQSESVADASYYSSVLASFGSAAGNPGSGPPGGGATAAAQPANPSGSHSAVGPGALIGGSTDAPTGGSSGNWQQSQYYR
The following text describes a protein:
Function:
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone; Probable source of extracellular death factor (EDF, sequence Asn-Asn-Trp-Asn-Asn, NNWNN) following processing and amidation. This pentapeptide stimulates cell death mediated by MazF. Artificial peptides with altered sequence show that NNGNN, GNWNG and NWN no longer stimulate MazF's endoribonuclease activity; other peptides (NNGN, GNWMM, NNWNG, NNNWNNN) retain MazF-stimulating activity. NNWNN, NNGN, GNWMM and NNWNG prevent cognate antitoxin MazE from inhibiting MazF; although NNNWNNN stimulates MazF it does not do so in the presence of MazE. EDF also stimulates ChpB's endoribonuclease activity in vitro; in this case NWN partially stimulates ChpB, whereas NNGNN, GNWNN, NNWNG, GNWNG and NNNWNNN do not. Only the wild-type EDF peptide prevents cognate antitoxin ChpS from inhibiting ChpB.
Sequence:
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTKVVREALETFMKETIDEGLWDTLSARLDFCNLDVNDTAAFSRLGAMLDQKNRITINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEINDQVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKSSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMITRDGRSWNEFE
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MIQLGDTLPDGILYHIDAATRILHILSIRHLFAHKRVLLLGVPGAYTPKHIPGYITKAPSLHAKGITNIYCLTVNDPFVTHQWSKTFADNNDAVRFLADGSATFTKALGMDIDLTRHGMGVRGRRFVLFADNLRVRKLIVEYPGEAANIAVDDVLKLFI
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
Subcellular Localization:
Nucleus speckle.
Sequence:
PTEEEAAKEESTPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVGEFKEGKAQEPSAAIPKVMQQQQQQAQTQATQQQLPQKVQAQVTQEAVVPKEPPPEFEFIADPPSISAFDLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFVKLKKEAENPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPSEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDDEDEKPEKAEEAPSQLDQDTQVQDMDEGSDDEDEGQKIPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDDSKEKIGPSKPNEIPQPPPPSSAPNIPTSAPPITSVPRPPAMPPPVRTTVVSAVPVMPRPPMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPTPMAPVHPPPPLEDEPASKKLKTEDSLMPEEEFLRRNKGPVTIKVQVPNMQDKTEWKLNGQALVFTLPLPDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Sequence:
MESMFSSPAEAALQREAGVPGLLTPLPDLDRVYELERVAGFIRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCMDVLGAEQAGAQALIHFGPACLSPPARPLPVAFVLGQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPLPVGSLSPEPKPLERFGRYFSLAPGRRLEEYGAFYVGGSEASPDPDLDPDLSRLLLGWAPGRPFFSCCPDTGKTQDEGARAGRLRARRRYLVERARDAHVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFRPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVPLPPPESELWETPDVSLITGDLRPPPAWKSSNDSGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MVDNSSTNNNGQQLPGQDPRVPWPVLTATGFILLAVAGPGVLSLAWNMAQLGWIAGPAAIILFSFLTWIASIILCDFYFSPDDPDKRNPAYMDVIRSYLGAGRTANVKICWVIQYLNLLVTASLYTDSASQMMADIQWVSKCTKNNNGSFKIPCWVYQKPYFIVFGVTQILLSQISDFRRLRWLTLLCFGAFLIYSSIGVGLSLTKIASNNWSIKGSLEPHGNINMTRAKKTRLIFNALGDIAGAFDFSSVLLEIEDTIGRGLPAQEAQKIMRKAIHYGLPATACMCLFFGCLGYAALGEETTEYIFLYGFYEHHWLLNIAISAMVLHYAGAYQIFVQPIFAMFEKAAVKRFSPDNEFIKRKIKIWTYEFKLFQLVLRTFFVIVTTLLSMFLAIYLDILVLIEILAFWPIVFYFPVKIYIMEKKIPMWSARGLGLQMISCGILIVTIAAAAANIVDVFLQDSYNPIMPDRYDWS
The following text describes a protein:
Function:
Required for normal morphology and function of ciliated sensory organs.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Cytoplasm.
Sequence:
MMLLPIFLLLCIGINLIRAESCPPSQAILPCRCSLRGKEIQIWCSHSNLPQIMDGLKAVERNIKGRIDELVLENNQLPALPGRFFGSLQIVRLMLRHNSIERVSNGWLNELENGLVEIFVVEPQLRSIPAESLNGMINMLAITIQSEELKHLPDFSGLLSLTYLSVQTGALQELPSHLFRHLPKLQHIHITGGSGLTRLEAGLFDGLISLKNLDLSHNGLNWIHLRALSRLPNLVSLKLSHNQISDVGMVGRIVKDLEHLKKLRLDNNLITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTPQLKTIYLQNNLIRRIHPESLLQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLLSELPYGALRGHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRNNSLSSDLPLPFWNLPGLKGLDLAQNQFARVDSQLLAGLPSLRRLDLSENGLIELAPNSFRHNPLLETLNISSNELTKIHSSTLIHLERLFEVDASYNQLKSVIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQNELRQLKDTSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLEYLDLSGNALLDISVGLGNLNNLRDIDLSYNQISRIQSDVIGGWRNVVEIRLSNNLIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQEFVLADNKLVELKDHVFEELPSLLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRNMENIGLRSMRNLEVLDLSTNGVKLVSTMPLKALNWLVELKMDNNQICRIQGSPFETMPRLRVLSMRNNQLRSIKERTFRNVRGNIAILDVDGNPIDCNCEMQWLSVWLQETNFPYPGPKCQDGRLLRSARMERSLCVGADIYGNERTDGNQLPLLNEHGDVFQRDLPDDFNDECEAGEGTRLPGDRPLVGESEYFYDQYVDATEAPDTTHSAISTSQRPKPTPTINSNIDLNNTILHTKYFNRKPQPGSGSPFTFFGYPLPSVSLGRFFGFGDRGRKQRTDSNDDMPATHRMAHISLPSGRGKTRMYQPNSAEFEKYLKDQQKQEKLNIARNRYVDTDSTTSSMEDALSNESGSAATTVGVFRTTFREPSSIERGGFRPIVPAHVGGFMPVHDPQQRRGLVEVVNITGNPSEIVQGIGQRKFIPISTQARPKPTKSSGESSETATYEVTETTPDITTTTPLMQRIATSTTKASTTTTRSTTTTSTTQVTPAENNASSSTELDSQYDDEDLEAQSVTLLRPPPLVQTTTAETILLIPPAEEHVAQIKSRSWVTTTTPQSPSDNQVTLAGPTSTVPPPPPASPPLRGGGRSTITKVYTPYQQQVAQPTAEEYQRTTPSGDNEGVASEHQLTANAQKRTELELLQVDRVDRKDGMDWYYESFKKKRDFNGGAAVRKTAHKEVFYDGVAASSSWNRLHKEILFISLLLLWRAC
The following text describes a protein:
Function:
Catalyzes both beta-1,3 and beta-1,4 glycosidic linkage on beta-D-glucan. Essential for (1,3;1,4)-beta-D-glucans synthesis in grasses and cereals (Poaceae). The mixed-linked glucans (which are not present in walls of dicotyledons or most other monocotyledonous plants) are particularly important constituents of the walls of the starchy endosperm and aleurone cells of cereal grains such as oats, wheat, rice and barley. They can account for up to 70% by weight of the wall.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAATAASTMSAAAAVTRRINAALRVDATSGDVAAGADGQNGRRSPVAKRVNDGGGGKDDVWVAVDEKDVCGARGGDGAARPPLFRTYKVKGSILHPYRFLILLRLIAIVAFFAWRVRHKNRDGVWLWTMSMVGDVWFGFSWVLNQLPKLSPIKRVPDLAALADRHSGDLPGVDVFVTTVDPVDEPILYTVNTILSILAADYPVDRYACYLSDDGGTLVHYEAMVEVAKFAELWVPFCRKHCVEPRSPENYFAMKTQAYKGGVPGELMSDHRRVRREYEEFKVRIDSLSSTIRQRSDVYNAKHAGENATWMADGTHWPGTWFEPADNHQRGKHAGIVQVLLNHPSCKPRLGLAASAENPVDFSGVDVRLPMLVYISREKRPGYNHQKKAGAMNVMLRVSALLSNAPFVINFDGDHYVNNSQAFRAPMCFMLDGRGRGGENTAFVQFPQRFDDVDPTDRYANHNRVFFDGTMLSLNGLQGPSYLGTGTMFRRVALYGVEPPRWGAAASQIKAMDIANKFGSSTSFVGTMLDGANQERSITPLAVLDESVAGDLAALTACAYEDGTSWGRDVGWVYNIATEDVVTGFRMHRQGWRSVYASVEPAAFRGTAPINLTERLYQILRWSGGSLEMFFSHSNALLAGRRLHPLQRVAYLNMSTYPIVTVFIFFYNLFPVMWLISEQYYIQRPFGEYLLYLVAVIAMIHVIGMFEVKWAGITLLDWCRNEQFYMIGSTGVYPTAVLYMALKLVTGKGIYFRLTSKQTTASSGDKFADLYTVRWVPLLIPTIVIIVVNVAAVGVAVGKAAAWGPLTEPGWLAVLGMVFNVWILVLLYPFALGVMGQWGKRPAVLFVAMAMAVAAVAAMYVAFGAPYQAELSGGAASLGKAAASLTGPSG
The following text describes a protein:
Function:
Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. Acts directly as a pro-inflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A (By similarity).
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor; Extracellular side. Secreted. Note=Cell wall anchoring is conferred by the LPXTG motif and following sequences. Anchored by sortase A. SpA from strains A676 and V-I is secreted whereas SpA from Cowan 1 and 8325-4 is mostly attached to the cell wall (Probable). Newly synthesized protein is deposited at 2-4 foci/cell and eventually is distributed in a ring around the cell.
Domain:
Each of the immunoglobulin-binding region repeats can bind the Fc region of an immunoglobulin. Cell wall anchoring is conferred by the LPXTG motif and following sequences (residues 482-516) which are necessary and sufficient to target other proteins to the cell wall. The YSIRK-G/S motif in the signal sequence plays a role in the secretion efficiency for SpA, it may have a specialized recognition mode (Probable).
Sequence:
MKKKNIYSIRKLGVGIASVTLGTLLISGGVTPAANAAQHDEAQQNAFYQVLNMPNLNADQRNGFIQSLKDDPSQSANVLGEAQKLNDSQAPKADAQQNNFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQAPKADNNFNKEQQNAFYEILNMPNLNEEQRNGFIQSLKDDPSQSANLLSEAKKLNESQAPKADNKFNKEQQNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDAQAPKADNKFNKEQQNAFYEILHLPNLTEEQRNGFIQSLKDDPSVSKEILAEAKKLNDAQAPKEEDNNKPGKEDNNKPGKEDNNKPGKEDNNKPGKEDNNKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDGNKPGKEDGNGVHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVVDKKQPANHADANKAQALPETGEENPFIGTTVFGGLSLALGAALLAGRRREL
The following text describes a protein:
Function:
The carbon monoxide dehydrogenase (CODH) oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (probably CooH). CooF is required in stoichiometric amounts in vitro for anchoring CODH to the membrane as well as for conveying the electrons to the hydrogenase.
Sequence:
MPPIKENVIIYANPDHCLSCHSCELACAVAHSGGHDMIEAIAANLPLHARNKVVSVDGTAMPMQCRQCEDAPCTFACPTGACRQADGQVQIVEQHCIGCKLCVMVCPFGAITVRSETVVEQGACTNRGVAKKCDLCVDWRASTGKTAPACVEACPTKAIRMVDLDAYRIALREARAREIAKSHRHMRVQF
The following text describes a protein:
Function:
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Miscellaneous:
MISCELLANEOUS: Present with 2270 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSTMSTPAAEQRKLVEQLMGRDFSFRHNRYSHQKRDLGLHDPKICKSYLVGECPYDLFQGTKQSLGKCPQMHLTKHKIQYEREVKQGKTFPEFEREYLAILSRFVNECNGQISVALQNLKHTAEERMKIQQVTEELDVLDVRIGLMGQEIDSLIRADEVSMGMLQSVKLQELISKRKEVAKRVRNITENVGQSAQQKLQVCEVCGAYLSRLDTDRRLADHFLGKIHLGYVKMREDYDRLMKNNRTTNASKTATTLPGRRFV
The following text describes a protein:
Function:
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Subcellular Localization:
Cytoplasm.
Sequence:
MNTADFDFHLPEELIAQTPLEKRDASKLLIVNRETGEMQDKHFHSIIDMLEPGDALVMNDTRVLPARLYGQKVETGSHVELLLLKNTSGDEWEVLAKPAKRLKVGTRISFGDGRLSAVVTEELTHGGRIVRFEYQRIFLEVLESLGEMPLPPYIHEKLDDRERYQTVYAKESGSAAAPTAGLHFTKELLAEIQAKGVHLVYLTLHVGLGTFRPVSVDNLDEHEMHSEFYQLSEEAAATLRSVKENGGRVIAVGTTSIRTLETIGSKFDGQIQADSGWTNIFIKPGYEWKVVDAFSTNFHLPKSTLVMLVSAFAGRELVLDAYHHSIQEHYRFFSFGDAMFIY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Sequence:
MSSRRKRAPPSRVNDEKKKQLCWNMHDDRKHEVIDLDAVDEDQSVAGTSSSTALIVISDDSANEELIHKEHVQRSLIFSTVTVDAEDSCNILAPVSIQLNIVILPYCPDPSWKILFGEFILQLLPYDFLIENIHKRSFTLMKTESNDKLHICFHAKNTEKLDEKEEPVLRNYEEEIMVESSLSSEILEHIMWLQKKRIIVLYQKPGEANCLKVGIYLLEAGLSKLEFLSDGGGRIKKANRLLQKLMEKFYHFIIPDILEEDEEESDRDIERQNIEELYDYVRLIHQKEIQFLKENVQHSALIPVLRPYQSEAVNWMLQRENFRNVSTNENALHYLWREFITLDGLKLFYNPFTGCIIRECPVAGPRWPGGILADEMGLGKTVEVLALILTHTRKDVKQDALMLPEGFLVNFFVPPQPTEGSKKKNIKKIELKLKEKVNYPSLRVMLLTAIKEMNVKKGSSIVAIFKYVNTIYKYDIQRHRQILKRTLEKLIAEKVVEQVKGHGLAGSFKLGKNYKDQKCVKSKKQKIRTSHRVQKKSLSDHKNEIKELGDKETCSVSIPKSSLTIDILANEHDYSATNKDNRKSKLDPQCWKIEEDSQHISGDLNGKELVSKDETHSIDFPKNTDETEEQEDILEAQSPALQEHGSIFVQHPGSIFPFNTSDYRFECICGELGLIDYKARVQCLNCNLWQHAECVNYKEENLKIKPFYCPHCLVAMKPVPTGATLIISPSSICHQWVDEINRHVRSSSLRVLVYQGVKKHGFLQPHILAEQDVVITTYDVLRNELNYVDIPHSNSEDGRRFRNQKRYMAIPSPLVAVEWWRICLDEAQMVECTTAKAAEMALRLSGINRWCVSGTPVQRGLEDLYGLVLFLGADPYWVKYWWDQLLYRPYCRKNTQPLYSFIAKIMWRSAKKDVIDQIQIPAQTEDIHWLHFSPVERHFYHRQHEVCCQDALAKLRKISDWSLKLSSLDRRTVTSILYPLLRLRQACCHPQAVRGEFLPLQKSTMTMEELLTSLQKKCRTECEEVHRQLVCALNGLAGIHIIKGEYILAADMYREVLRSSEEHKEKLKTDSLQRLHSTHNLMELLAAKHPGIAPTLRDSRLQEECEQLRQHYMSKSNAEVAEAQQALQPVVQTIHELQRKIRSSSPWWLDVIQSAIQYAIDEELLQRVQNDLTSNYKQQTNKLSMADKFRDCRGLQYLLTTQMEEVKKFQKHVREAVKKLEGPPSKEVIEAATICHLRPVRLPLNNCVFCKADELFTEYESKLFSHTVKGQMAIFEEMIEDEEGLVDDRLPTTSRGLWAASETERSLKTILSFAKAHRIDSRVVEEGSIFLELFEAWKKEYKLLHEYWMVLRDHVSAIDELAMATERLRVRHPEEPKPNHPVLHIIEPHEVEQNRVKLLNDKAVAKSQLQKKLGQLLYLTNLEKSQDKTTGGVNPEPCPICARQLGQQWAVLTCGHCFCNECIAIIIEQYSVGTRRSSIKCAICRQTTSHKEISYVFTAETPNQEDDIPVKGSHSTKVEAVVRTLKRIQFKDPGAKSLVFSTENLSAFKYDPKINILLLPLHTGSNGLNIIEATQVLLVEPILNPAHELQAIGRVHRIGQTKPTIVHRFLIKATIEERMQTMMKTVERSHSSSSMKQSEASVLTVADLADLFSEETEELE
The following text describes a protein:
Function:
Acts as a translational repressor of SRE-containing messengers.
Subcellular Localization:
Cytoplasm. Cell projection, dendrite. Synapse, synaptosome. Note=Enriched in synaptoneurosomes (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1.
Sequence:
MMFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSQTQARFLQLCLEHSLADCAELHVLEREANSPGIINQWQQESKDKVISLLLTHLPLLKPGNLDAKVEYMKLLPKILAHSIEHNQHIEESRQLLSYALIHPATSLEDRSALAMWLNHLEDRTSTSFGGQNRGRSDSVDYGQTHYYHQRQNSDDKLNGWQNSRDSGICINASNWQDKSMGCENGHVPLYSSSSVPTTINTIGTSTSTILSGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASSGSGGSEHLEDQTTARNTFQEEGSGMKDVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNVTKGARHKIVISIQKLKERQNLLKSLERDIIEGGSLRIPLQELHQMILTPIKAYSSPSTTPEARRREPQAPRQPSLMGPESQSPDCKDGAAATGATATPSAGASGGLQPHQLSSCDGELAVAPLPEGDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKCLIHEAFTETQKKRLLSWKQQVQKLFRSFPRKTLLDISGYRQQRNRGFGQSNSLPTAGSVGGGMGRRNPRQYQIPSRNVPSARLGLLGTSGFVSSNQRNTTATPTIMKQGRQNLWFANPGGSNSMPSRTHSSVQRTRSLPVHTSPQNMLMFQQPEFQLPVTEPDINNRLESLCLSMTEHALGDGVDRTSTI
The following text describes a protein:
Function:
Heterogeneous nuclear ribonucleoprotein (hnRNP)-protein binding the poly(A) tail of mRNA and probably involved in some steps of pre-mRNA maturation.
Subcellular Localization:
Cytoplasmic granule. Nucleus.
Sequence:
MAMMMPPQQQGGYHHPQTLEEVRTLWIGDLQYWVDENYLTSCFSQTGELVSVKVIRNKITGQPEGYGVIEFVSHAAAERTLQTYNGTLMPGTEVAFRLNWASFGSGQKVDAGPDHSIFVGDLAPDVTDYLLHETFRVHYSSVRGAKVVTDPSTGRSKGYGFVKFADESERNKAMSEMNGLYCSTRPMRISVATPRKTVGVQQQYVTKAAYPVPVPVPSAAAAPAYVAQPAQVLAPENDITCTTVLIANLDPNVTEEELKKAFSPLGEVIYVNIPATKGYGYVQFKTRPSAEEAIQKMQGHVIGQQAIRISWSKNPGQDGYVTQADPSQWNGYYGYGQGYEAYAYGAAQDPSVYAYGGYGYPQYPQQGEATEEVTNSAAGGVAGAEQELYDPMATPDVEKLNAVSLSVHANAILGRLLWQRTSALSSQLGK
The following text describes a protein:
Function:
Centrosomal microtubule-binding protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
Domain:
Coiled-coil domains are critical for microtubule binding via the formation of a two-stranded coiled-coil structure in homodimers.
Sequence:
MTMTTNAERKFINLRKRLDQLGYRQPLAIESLPLVEKLFSDLIHTTESLRNAKLAAGKTEKESRNVDAILEPYKTENARLVKENNEMHLGLLKLREEKDRISRELKAYIRKLDHETSDLKFLNNQYVQKVRSLEKDSNGKTERILQLQEKNMQAVVQTPGGKKRSIPFRRQRMQTDELLPSSGGYVPPAVAQPDDPYIADLLQVADDRIQELQKEVAQLKLDLERAQGGIKHLNKQVEERDKEIERLNRALDGGRPHDVISLEAQNISNEKLIAHLNLQIEYLQETNRSLEQRVDSLQQKKKTVSSEVADLSARNQELCQELTQIDQLAQQLEKDKEMVLETADMELQEAKKAIQRQQRELEGQEEVISTLRRDMADGDHVKDQLRNQLLDLQDQNNKMEGLIHFLEEDKKRLQDKIEAMMQEDKEMVLELERMRARHGMCGKDHSPSRLDAFVKSLEEERNYYREEVERYRLVRGRTDRSPTPVGRGRSPRGRGSWHGKRDGDAELSRVVKERDELQSVLLGFEKHMEDIQTRVKLLTAERDQLSSQCQQAQEELRRVQRELESSELQRRIRDDREQTEAELQRVTAERDALRDRLKVAHSTALTDREQEEFRFLDLENTIEKLEREKADLRAQVTVLKESRVVVEKELKAQSAVLLQNVEEATQQRVESSALRLLQEQMEQSLSDVQHRLSVKTNELQAAHQQIDKLEEKIADLSRHGSSQKDEVVILQNTIASLDREKDTLQDAVDQKTESVVLLQQEVHRKEETLLEVRLTVTDLENSLNQLQAVLSSREREIASLRRQLDQSQEELFSVSRDREVALRENRRLQDDLATMTRENQAVHAEMQEALNERDELKLRVHSYISEVARIESLMAAKEQENRDMLERFRSIHTESEDKELKLQQSEGLNNSIRLELLSSDTERRHLRERVSLQDREIQEHLNALQAYEAQVSSLARAMSRLEEEVQAARAEKASVLADLASVRELCVKLDSSKELTVRQLTSKSMELERVTGELEDVRSEMELLKKQLGSERLTVRNLETLLSTNRQKEFQTHISASEKESELKVLKDRLALADSKTAGHAREVSQLRGKVSQLQTEMDVLKRQLTTERFERERAVQEMRRQGLSFSSLRSSSPLSTSLSPRPASPERSILRTPERSTDKTQDK