lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.
Sequence:
MEGKRRKERKRRKGREEGRKEREGRKEKEGKRRKGREKEGKKEEEGKRRKEKESKGGGEEEGGGGGGGSRRRQVPPPPPPPRAPIGRPAGAIGGRRLAGGVGRAVKCSAAIGGARVTCRAPIGGARLSLLPRPPPPSSAGGRPPGPGAKPCALRSAPCALHGGGWERLGAERSRAEPSRAERNMAPHGLGALALLLLYLVGAVGGGGRDFYKILGVPRSASVKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDEEKRKQYDDYGEEGLKDGHQGSHGDIFSHFFGDFGFMFGGNPRQQDRNIPRGSDIIVDLEVTLEEVYSGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVLKHPVFERRGDDLYTNVTISLVEALIGFEMDVAHLDGHKVHVARDKITKPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEEQREGIKQLLRQGSVQKAVQKVESVTERKEPVCRARWKFGRCASWKNGCVLSDQGYFFLFYHAPFSPALSLLIPPWA
The following text describes a protein:
Function:
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Subcellular Localization:
Cytoplasm.
Sequence:
MVYLQKQDKEVFDAIKLELGRQRANIELIASENFVSEQVMEAMGSVLTNKYAEGYPGKRYYGGCEFVDIVEDLARDRAKKLFGAEYANVQPHSGAQANMAVYHTVLEPGDTVLGMNLSHGGHLTHGSPVNFSGVLYNFVEYGVREDTKEIDYDIVREAALKHKPKMIVAGASAYPRKIDFAKFREIADEVGAYLMVDMAHIAGLVAAGLHQNPVPYADFTTTTTHKTLRGPRGGMILAKAEWEQKLNKSIFPGIQGGPLMHVIAAKAVAFGEALQPEFTTYCEQIIRNSKKLAETLQANDVAVLTGGSDNHLLLIDLKPLGLTGKAAEKVLDEVGITVNKNTIPFETESPFVTSGIRVGVAAVTTRGFDEVAIEKVGVLISEVLHNLENEEVLADVKARVATLTNEYPLYPSL
The following text describes a protein:
Function:
Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKISTLIVVAALIGLCLAAPPSAEEMGMTPDEWSNWVYSQYGVYGMRPSRAANLVGMILFIILWAIQGALALYYRQWWFGGAFFCGICLEFLGYLGRFLSTWDLQNLNEFILQIVCLTLAPAFIMAGVYCLLAKFVVIYGESYSRVAPLVYTLIFVACDLISIVIQAVGGGISATALYDNKSTDDGTHIMVAGMAFQVFTMSIFFIMTTDFLWRVHKGIRNPNVADSRANDPEIIAIRESPKMKYFVIATYIAFGFVFTRSVYRVVELAEGWYGNLLQHEAYLLVLDGLMMLIAITILTVFYPGFVWGRTHINAGAVKHSKSEKNEFQDVQQEHYPEQQEYPEQRDDGSYGKETESSV
The following text describes a protein:
Function:
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (By similarity). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity).
Subcellular Localization:
Cytoplasm. Postsynaptic density. Cell projection, axon. Cell projection, dendrite.
Sequence:
MGDPAPARQSDFIFLVALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLNSQKQQQQQQQQQQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNSPLAKTKPSSAGPEPPIPQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNTSSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPADFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEDEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEVSGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSQGQSPPTKDGGGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
The following text describes a protein:
Function:
Bifunctional enzyme which catalyzes the first two steps of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
Sequence:
MDYENFVKSAEEINNLHNVNYLETKDLNDFNWKAAYYICKEIYDKQQINKDGYVVIGLSGGRTPIDVYKNMCLIKDIKIDKSKLIFFIIDERYKSDDHKFSNYNNIKFLFHNLNINEKEQLYKPDTTKSIVDCILDYNDKIKIMIEKYKKVDIAILGMGSDFHIASLFPNIFYNIYMNNYQNNYIYNEKTLDFINNDQDNDNLKYLKEYVYFTTTNQFDVRKRITVSLNLLANASSKIFLLNSKDKLDLWKNMLIKSYIEVNYNLYPATYLIDTSCTNENVNINNNNNNNNKNKNNYCYSNTTVISCGYENYTKSIEEIYDSKYALSLYSNSLNKEELLTIIIFGCSGDLAKKKIYPALFKLFCNNSLPKDLLIIGFARTVQDFDTFFDKIVIYLKRCLLCYEDWSISKKKDLLNGFKNRCRYFVGNYSSSESFENFNKYLTTIEEEEAKKKYYATCYKMNGSDYNISNNVAEDNISIDDENKTNEYFQMCTPKNCPDNVFSSNYNFPYVINRMLYLALPPHIFVSTLKNYKKNCLNSKGTDKILLEKPFGNDLDSFKMLSKQILENFNEQQIYRIDHYLGKDMVSGLLKLKFTNTFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYGIIRDVMQNHMLQLLTLITMEDPIDLNDESVKNEKIKILKSIPSIKLEDTIIGQYEKAENFKEDENNDDESKKNHSYHDDPHIDKNSITPTFCTCILYINSINWYGVPIIFKSGKGLNKDICEIRIQFHNIMGSSDENMNNNEFVIILQPVEAIYLKMMIKKTGCEEMEEVQLNLTVNEKNKKINVPEAYETLLLECFKGHKKKFISDEELYESWRIFTPLLKELQEKQVKPLKYSFGSSGPKEVFGLVKKYYNYGKNYTHRPEFVRKSSFYEDDLLDIN
The following text describes a protein:
Function:
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRKSSGSAGLPQQLASNRRNPLTRLSQAESMAHRRAPLLLTSSQSSSSSSDSTDSPVIDVIPPVFQERNVPDFEIDRTRMAGAATVPSLSGTHHRQGVSRPMNHVDLVGNSPSGSPRHTRQTTSAPASPNLRIPHLANVPVTNHRTMLQARRMVEQHGSPPTGGEDSSLVSAAEGIMAAGSAALTSLQLRIPGSPSSSGYPSPTTSFLSSSETFPYPYHNIPSSSSLPRDPTRSSQTVPMRNGQGPSKHAAGGSTLKRAGPYLLGPRLGTSPVRSIVQCLARKEGTDDFYSLKILTLSENGRENQDERQGKMLLHTEYSLLSLLRDQEGVVHHHGLFQDRAYEIRPGTSTSGRKTSYKKRLCLVLDCLVSHDFSSRTVDLVNLQHHVIHEKKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTRQITLTNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGKPYLGKPSDMWALGVVLFTMLYGQFPFYDSAPQELFRKIKAAEFTIPQDGRVSENTTGLIKSLLVLDASTRLTASQVIESVKTTLAMWKTMAMQGEHLQVVPDIDNGDNDAPLGKKPCDPSSSGAASSCSKAVPTADWELKLHQPSQPSPCLTSYRAPRSPLSAHRHPPVRRLSHDAQPLSSAEAANFYNARS
The following text describes a protein:
Function:
Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo. Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir).
Subcellular Localization:
Mitochondrion.
Sequence:
MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGTSVTSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAKDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSSCSDEKIETKAPVLIETLPELVEDDNQLIKIGIAAMDRKARSKPMRNILSRLVATNKFECIIFGDKVILDEDVENWPVCDFLISFFSTGFPMDKAIRYVNLRNPIPINDLPLQKLFWDRRLVLAILDKIEVPTPKRCELNRDGGPKVDKEVASEIERRFGLKLNAPRPPPKSFQVQNDSALLIDGIRMEKPFVEKPVSGEDHNINIYFGGGNGGRKLFRKIANQSSILDPELSDPRTEGSFIYEQFMKTDNYEDIKIYTLGPDIVHAETRKSPVVDGIVKRNLDGKEIRYVVELTPEEREIARKISTAFSQTVCGFDILRVKGKSYVIDVNGWSFVKGNDSYYDKCADTLAKFCLKAMPSLTLPSPNPRQDSKQKPTVSSWKLKAMICVFRHADRTPKNKLKFNFTADEPGSQPFIKLLQGRKDEIILRTSDHLQLIASATDEAITIDNSDQSKLERLKLILSSKMGKQGLKAQLKPSFKTEDGSLEKITIVIKWGGEFTHAARYQSRDIAENFAKDLRVMSKTMLDDVTIFTSSEGRVVATAEIFSAGLREACKAHSKTEPKTIPLVTRKDLLDDSNAAKEPMDRVKKRLKVLLRHNQGIEVDWPIADKEPFDVVQEVIAILKEQRDVMHMNWEKIDVEQIQSRWCCGECPVLFKERWDKLFSDWCDGALDPSRVCELYDSLKYDSLHNRTFLETIFSNSSTWPSPVCSDASSPLAMPGSAPSMMSSGSSFSSHQHFNPIGLIRSGDSSPTPITTSAVSLAHHHHPRQASLKYSNPQSPDGTIKDDDAGWCETESLQRLRKLYKDAKLLFDLIAPQEYGIDQSEKREIALLTSLPLLQKIVNDLNAAKESQGGLARFYFTKESHMHTLVNLIKLSKLKLAHRDVMELDYMAYLCFEVYERISEVGKSEHSVRISLSEGAHGIPLDTSLDAKHALQVIPRKQLIPHKDLDEVIASLEDWGENLFELKKSTTPYDGFLPLEGEDIFSKESLKLSPQPQTSS
The following text describes a protein:
Function:
Probably acts as an electron carrier involved in oxygen activation and/or lignin formation.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAMNGLSKMAVAAATALLLVLTIVPGAVAVTYTIEWTTGVDYSGWATGKTFRVGDILEFKYGSSHTVDVVDKAGYDGCDASSSTENHSDGDTKIDLKTVGINYFICSTPGHCRTNGGMKLAVNVVAGSAGPPATPTPPSSTPGTPTTPESPPSGGSPTPTTPTPGAGSTSPPPPPKASGASKGVMSYVLVGVSMVLGYGLWM
The following text describes a protein:
Function:
Negatively regulates Wnt/beta-catenin signaling during development.
Sequence:
MAYDDSMKKEDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREEEEVAAQVRSSSKKKSKDSDLFFLGTDTHKKKRKHSPDDFYYGDISTLESSQKKKKKSSPQSPDTAMDLLKAITSPLAAGAKSSKKAGEKSCSSSSHSESRKEHHKKKGNGSTGEPSLDDSNAHKPKRMKPLYVNTETLTLREPDGLKMRLILSPKEKGSSSVEEEAFQYPAQQASLKKPSKKLAREEQGALLLGHELQSLLKTARKKHKSSSDSHSSPGPEGCGSDGSQLPEPHSANLDITGLDPILVESESSSAGELEAGELVIDDSYREIKKKKKSKKSKKKKDKDRHKEKRHSRTKRSSTREHGTAREHMLVSSPASSIPTLPLPALHTDGHGEKKKKKEEKDRERERGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWKQKAQYLQHKQNKAEATTVKRKASSAEGTMKVRASSVGILSPQKKSPPTTMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL
The following text describes a protein:
Function:
Regulates exocytosis by functioning as a GAP for SEC4. Also required for efficient polarization of the actin patches.
Miscellaneous:
MISCELLANEOUS: Present with 1730 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Bud. Bud neck. Note=Localizes to the presumptive bud site, the bud tip and the mother-bud neck.
Sequence:
MIMSSTMSTEAALVPNESVFDTVSSFNEDDANYSVLDLYDDDDEGDDSSTVERKEILTTRELEKAKAFTSLIMADPENFDRYGFSKKGYFISQEEYDKWWTEYNRYTERRKKKWENFLLKNKIELHNDNPLVYPARTDELSKFVRKGIPAEWRGNAWWYFAGGQRQLDANVGVYDRLKSDCREGAVSGKDMEAIERDLYRTFPDNIHFHKESFQNGEPAIIRSLRRVLMAFSVYDKTIGYCQSMNFLVGLLLLFMEEEKAFWMLVIITGKYLPGVYESDLEGANVDQGVLVLCIKEYLPEIWSHIESSYMNGNGSTDQISGPASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVALGILKLSESEFLESKSQKLFRQYSSYTFGGSNDSDSTFKRLKNKIKTQEEADMEILQVIQNFPKRLLNPNDIFEKVLMKKKVALNGITQEKIDRGREYVAMARNRQRASSRPKERRK
The following text describes a protein:
Function:
Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.
Sequence:
MPTKKHRRKDPESPQEPSEKTKEQLVEGELRKLRQQFRKMVDSRKSFNFRSQQKITNQRKEIKTLQEEQDEITLLLNLIKSSRNLDLNEKNYLELRFLLQTKEDYEALIKSMKLLLAELDEKIVQMEKKIINQRQIFTKIQEANNPRKLQKQIHILETRLNLVTVHFDQMLTTNAKLRKEIEDLRHEKAAYDNVYQHLRRRLLTKKKTMNVAIEQSAQAYEQRLEAMARMAAMKDRQQKDISQYNLEIRELERVYDHETKLKSFLLIKLNDRLEFEEQSKKEEALKAKKYGKKSKGASFESYEVAHLRLLKLTKTGNLNQLIEEFLAKEEKNFARFTYVTELNNDMEMMHKKIERIQNEILRLRSQQKSSHDDSYSILRELEEKLKKTTEEADMYENDYREITKTLEYLKNSVENLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLVLESYKRLMEMEVAEAEVQPSFLNPFWGGSALLKPAEPIKVIPPVLGADPLSDKLDEVEQPLDHSSLRQMVLSHYATRESRNRDSMPEKGDELKSKKKVTV
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEIRNQTRYFLLLGFTEEPDMQPLLFGLFLSMYLSTFTGNLLIILAIISDSHLHMPMYFFLSNLSFADLCFTSTTIPKMLMNIQTQSKVITYAGCLSQVFFFFVFGCLDNLILTVMAYDRFVAICHPLYYTVIMNPQVCRMLALGSWCISVTGSLLDTLTLLRLSFCMNMNIPHFFCDLPEVLKLACSDTLINNIVVYFVVVVLGIFPLSGILFSYSQIFSSILRISSSKGKHKAFSTCGSHLSVVSLFYGTSLGVYLSSAATSSSRTSLVASVMYTMITPMLNPFIYSLRNRDMKRALGRLLSRVASLSDGVVAGFS
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQKNCCKCQATNTIELSTIRNTTWCRQCFIEQINIKFFQGLKIAKEYCRPPPKRDGIRTITEPASLVIHFKNDLSSFLTLQLMRNYLNTNQDRSTAKWKSPIDFSTIEVISIDFGSASPYISIDSSSETKLVNEEGNRPPTENEGTLRSMVESLGFSFKILNLDDLFDSPASVEESSPNGCSPRCFVDLSDPNLPIKTIAPTDPGFSTPSSKETAMKPLARTLRPLTQTSRRSFIESLINKRLLDFCKHKPRNKVLVKPTTSTQMAIDTLAGVSLGNGWSLDQQIGPSSYIHDVLVCRPLAQIVDAELFQYSKLMQLDHPYPLIHQAPTKKADIPALITDFVVKLEENYPMTSSVINQTVNKIGKNKSALASSSTTSTKTTRTATNGKDCSVTRTCPICHLSSDRKANEWKRSITLSTHEPPTTPTPNASSDESEIVRPVEEEEEDEPMRLRDQLCYACLVTFNDHQYIAHPSQSGHDWVQLPGFYQPLTQLPVAPAATPPRPSLSANHLQAVLDQFLISD
The following text describes a protein:
Function:
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.
Miscellaneous:
MISCELLANEOUS: The name 'dim gamma-tubulin 5' derives from the decreased gamma-tubulin staining of the spindle pole seen following RNAi-mediated knockdown of dgt5 in S2 cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere. Note=In mitotic cells, detected on kinetochore microtubules but greatly reduced at the spindle equator where only non-kinetochore microtubules are present. During male meiosis, localizes to kinetochores in a microtubule-independent manner but does not concentrate on spindle microtubules.
Sequence:
MAYQEKITEFKNWATNLGCPPTALPTDDALRRIFKSGSSLLLNQLQSRIQPVDYVREVRENLLIAQVARYKDKMVPLASRSFQPPELQRYQKIQELKKHKEKANQQLTEARKEYQKLSAGIKTKNIQTISAENRKQLLESKCNILDLKLESLNKNYDQELKNKIQILGTTPVKLSARNASEAQATRAVEQALKQLETFYGMCDDGNAVNNLAEAKQRLWDQMRSTFADIPNSLLLNVVMKIKEEQLQHIMKLNESRGECTNDKPPLNNYEVKLLKTKADMLGLAAKYFAAQKELELKEERFCQDYSVFVDKLQSKVYRFNGISLGDEENADELISDYLVQYNMRNFNRSQNEFLREQIEQLRLELDAGAKQLENHDLKLGSVKQVYGDINSSINRIQQDMVQLSQIKEKILFSRNMMKNLLDDMQAATQKQNAKSQLMSTKLKVSNMSMLGAESFCLANDSVFSSTKVEFDGNCSAINSTMRRSFDNKTLVPGGAASTTLMAASGATLPSHLLEFNTFLEIPLEKFSCTPRACSFLLSANPLIVEAQELASTVQLAPGYLLTPFGALQEVRKRILWASAIAAHTSELKLNLQPLIVDPHDLRLKASRQHEEIDQLLDNLMAIGVKTQLQLEKAERIYQFLLENPLRRYVPPSKRYNNGSFADYESEFNLYYRMTTNGSSMRAPPN
The following text describes a protein:
Function:
Functions in the galactose metabolic pathway via the GAL83 protein and that it may control the level of ENO1.
Miscellaneous:
MISCELLANEOUS: Present with 721 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MVESKNTELSQGTWLNKPKSVFQEAGKVTLETDEKTDFWRETFYGFTRDSGHFLGVETGSAFTAQVRVQGSYESLYDQAGIMVRIDDGHWLKAGIEISDGHAMLSSVLTNGKSDWSTAVYGGNARDFWLRVTVEKGVLRIQVSSDKKTWPLVRLAPFPTSDHYLVGPMACTPERGGLKVTFSEWSLTAPLGKALHDLS
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MERPGARMAGLEVLFASAAPAITCAQDALVCFLHWEVVTHGYYGLGAGDQPGPNDKKSELLPAEWNSNKDLYVLRYESKDGSRKLLVKAVTVENSMIINVLEYGSQQVSDLTLNLDDYIDSEHLVDFHRTYKNSEDLRSRIVSGIITPIHEHWEKASVSSAHREFPPATAREVDPLQIHPQHPHTSRQPPWCDPLGPFAVGGEDLDPFGCRRGGMIVDPLRSGFPRAIIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL
The following text describes a protein:
Function:
GATA-type transcription repressor that regulates iron- acquisition genes through specific binding GATA sequence elements of target promoters. Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity). SreA targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis.
Subcellular Localization:
Nucleus.
Domain:
The conserved cystein-rich region (CRR) localized between the zinc fingers is also involved in DNA-binding and transcription repressor activity (By similarity).
Sequence:
MLASIPHMETLRSLPRNPDVVARHPSAEDLDAAQQLISSAQAGREHPQDRHYTDNGSRKSEAGAPHSHHEGEYPIVQTSETPMNGHHVEKTSPKSQKDTSFLGHSCSNCGTKSTPLWRRSPTGAMICNACGLYLKARNVARPTKRNRTQASPEAYHPQNQSVGSQPDPAVTGSEGCTGSCPGGGNCNGTGGAEGCDGCPAYNNRVYKSTARGNVAAHALNRAGNSDAVPSPEAEAPARNSGQPEGNMLVACQNCGTTVTPLWRRDENGHPICNACGLYYKLHGSYRPTTMKKTIIKRRKRVVPALRENSPTAATHSSHGSSASPEASSPATLAYSHDERHRYYSSEPVDQYHRISPAAQRPFGFAPPPVDFTNFNSGAVTLPHHPPPPRLLEPGHPPLSQFARRSISPSSSGNSKKRTLAEAGANTDTGPVPTTLEAGSNQLPPIVSSANPPPPARLSSISSILNHAHARDESRLDPSLAALGRQQQSQPHHPQSSPLAPTQAASQSLPGVSNMDNHVEDRRAKLQREAEEMREQLRAKERELAELAGQ
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Sequence:
MTEQKQQKKWHEKRKHLVGVVVSDKMDKTVVVKVDRKVPHPIYGKHIIKSKKYHAHDEHNECRVGDIVMIRETRPLSKTKRWVVVKILQRARRPEEEIQKQQEGQEQ
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase.
Sequence:
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKCYIREVMTHKEYDFFTAVHRTKGKK
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MREDCQICLSQAAKYTCPKCRVKTCSLPCVQSHKKLQSCDGKRDKAGYIAKKKYDMACLTSDYCFLEDVSRAADNATRDNANSPSLVHANTLHKPARPLSYMQHLLTKECRSRGTTVKFMSAGMKRHDANQSMYRKKDQTICWTVEWTFVMGESAPQIRVLDARVDETCTLKAALERLLADRPGNTIQRHNLKKFCSDSGDHSVSVKLLQEDIPVNERMQGSGLDTNLTLRQVLQDKTVIEMPRFIVEIDGTRPATTIQ
The following text describes a protein:
Function:
Regulates membrane-cell wall junctions and localized cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKARRLVAIALRVAAAAAAGVAAIVMATSHETTTVFGMQVEAKFQYTPSLVFFVSANAIACAYSLLVLLVPPATSPAAKLVLVADAMIGMVLTGAVAAATAMSDLGKNGNSQARWLPICGQIPSFCDHVTGALACGFVAVVLHFIALLYSIYTMDG
The following text describes a protein:
Function:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MLIFFYSDAHDSKDGATELLNPDSYNPGKPNYHPIQDATWKKGENVPYMVLAKTLELIEETSSRLKMIEILANYFRSVFLLSPDDLLCSVYLCLNQLAPAYMGIELGVGEGIIIKAIAQATGRATDKVKSDVATKGDVGLVAEASKGTQRTLSIPVSLTVKSVFTKLTEVAVMTGNSSQIKKVDKIHGILVAAKQLESRFITRSLAGKLRIGLAEQSVLQALAFAATATPPNQSTPPTQLNCFAGLSSETIKAKVEASAVILKTAYCQCPSYDQIIPVLLREGVEALPLHCTLTPGVPLKPMLACPTRGVGEVLQKFESTKFTCEWKYDGERAQIHLLENGEIRIYSRNQENNTSKYPDIISRFQSWIEPSASVRSAILDTEAVAWDTDKKQILPFQILSTRKRKDAVEADIKVQVCVYAFDLLYLNGESLVTMPLIERRQRLWNSFHKVDGQFGFATSRDPQTVEEIEEFLDESLKGNCEGLMVKGLVKDATYEIAKRSKNWLKLKKDYLDGIGDTIDAVVIGGYLGRGKRTGLYGGFLLACYDEANEEYQSLCKIGTGFSDEDFQAHSDFLKNHKIPKPKPYFRFDPSLSPDDWFEPVQVWEIKCADLSISPVHRAATGIVDPVKGISLRFPRFIRIRPDKNPENATSSEQIADLYNSQEQVKNKKTDDDEEGFY
The following text describes a protein:
Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
Subcellular Localization:
Secreted.
Sequence:
MFLFSSYEQKFLTMGVFQQIAVMKVFVVLAVAVLSGCHANLFYADAPKPQLEVLTDAFWDYIAKATQTADDTLDMIKTSPIGQEINARLTESADVASRYAVALQEQLSPAAQDMMNRITKEADVLKNVLTQELSSVRGKLEPYTDNMRAQIQQRVEKLKQDLSPYADSEALRATLLQKSEELKTNLEQSVKDLQAQLGPYTDDLKQKVDQHLQKFQKSVAPMTEKVQLELSQRANLVKQMVAPYAEDLREKLDPYAQDLQAQLMSLYQSYVNAN
The following text describes a protein:
Function:
During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEAQYSGVGSIPENSRSSHELGIQDQGSPQLRIVLLGKTGAGKSSTGNSILGRKAFLSGICAKSITKVCEKGVSIWDGKELVVVDTPGIFDTEVPDADTQKEITRCVALTSPGPHALLLVIPLGCYTVEEHKATRKLLSMFEKKARRFMILLLTRKDDLEDTDIHEYLETAPEVLQELIYEFRNRYCLFNNKASGAEQEEQKRQLLTLVQSMVRENGGKYFTNKMYESAEGVIQKQTWKKKEFYREELERERARIRREYEAEIQDLRDELERERRRARMEREFNENELIFAERQQNARREVENTSMIYLN