lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor of the kdgRKAT and kduID operons for pectin utilization.
Sequence:
MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNIKKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMVCNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLKLDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNGLVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQDIGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVIMRKSL
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MYTETTIDPDPRQPARQSCAFPTVTKPTLIGFFSLNQERQYDASAAQLKYLTLPRDSLLTELRLDLNEGFETHHPKPDSAQEERINMLLTFIHQSDSRQLWIPQENGQLRLKHNFVCFRGLLRLLACTPYEWKTPWIVQAIRYRGTIYLCEKATPEKEQSVRNETEQQKRFCYYGFKFEQHILTEEPAVEPDTSAPVRLGEEFCAMFDTTLAGHRLLYGAEMDGIVTDRPLDRERVSVDELRRCEFVEVKVKRRETAQRQVDNFYRFKTKNWWCQSFLVNVQRLVVGLRDDAGIVREITNVRLNDLCRQSARYWSPAVCMDFCADLLSEMVRVMGRTDSSRKVYQFEYDARQCRRVRYRVLEGESFLPDWYTKYVEEMQPKWKD
The following text describes a protein:
Function:
Involved in the determination of the onset of polarized growth. Required for the ubiquitin-dependent degradation of RPN4. Cooperates with UBR2 to transfer ubiquitin from RAD6 to RPN4.
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium; MISCELLANEOUS: Is a short-lived protein whose degradation is dependent on the UBR2/RAD6 ubiquitin-protein ligase.
Subcellular Localization:
Cytoplasm.
Domain:
The MYND-type zinc finger is essential for the ubiquitin-dependent degradation of RPN4.
Sequence:
MRDSNHRSLTSNKPIVTITSTVYDRRALDINSSIPLINSLNYLTYLTSNSSKVRETVANDGALERLVSILRSCHLSLFELLDLDLENFNEHENIKDLWKEKRLALCAWKWTLTFQCLVLTGTRGTEQIRKKVVMSGVLSVLVTVLDNYLLYHKNYDFIKDQTMTFDFKGITTETMYKFMRKDENETYQQYIEFITGQDKLKLSTDKNFLNERLVAPSMTIPTDFSDIWGRFADLASNFEPDQERHDDDIDIDSEVESENFDAHKNFFSQPDINRPTISTPREFFLGRIVPKQDDVIWSLQLLAFVSKYTYMKSTLQNVELVESLSFRSMAYKIKQRISEENDLEEQERDVTVKLSSLYPYLSKNPENNSKVKALDTSKMDPFFKELEELSNRCQQEEQNEICNNHCPVLNLFERYRVPKPSDDNAYGKDKERINLRKKISDNFERRWSYDKMKKELTNIVYKNKVLTNVVNIFPLVEKYTVSAENTHDVIYWSSVIMRNSCRKNEILGVRQCANFSCGKWEDFPRQFAKCRRCKRTKYCSRKCQLKAWGYHRYWCHEVGSSHMRSTNTTTGVNTPNEPSSLNATATTAADVSNSTSTFTPNISTTVPDEISNRDENSIPE
The following text describes a protein:
Function:
Lineage-specific modulator of primary metabolism. Influences flowering time.
Sequence:
MEKESHEENNHTISGDLTAKRKRGRPRKQLKLESNEHSLGHSPSFSRSQQQSRQRNDDEAMVGQPISGVIEATFEAGFLLSVKVGNSDSMLRGVVFKPGHCDPVSVDNDVAPDVPMIRRNSDVMHHDGSAKRGRKSRFREKRGSGVRSRALVPVPIQPAHPTIPNNLIVPVVLQPAHLENGGERVPIDHSPMQTETGSQASGASNGKPFETLLTQVMNKGQVQHTTQSVEPESDEQALSIEPLQAIHPIHPVHMLKPMPSYGRGKMTELLQAVQENVRETHFSQGH
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MEIEEVEVETVTSIDQYECQNTVEKEKAYTRYIIRHNFLTYSFNPEIHIKWLTLSIHKPLPSGFMSLDSSTPWILYWTLNPLRLFGYNVDKYLNEYTEALRLITLPDGVIRGSQQSIPIVAGCYSGVCTMIDIGTVNAYQLINRQNTYNFLISKKFPDGSFEMNCDSGDIDTRACYCAISTAYVLNILDDNLKQGVAEWLLKCQTYEGGFSGCPGGEAHGGYSYCAVAALALLGRIDEIDINKLLRWLIQRQKPIEGGFDGRINKLVDACYTFWQASIFGILKKYSKTFQASPVFPNVDKLLDYIILASQNKDGGYRDKPSKKPDLYHTNYALSGISSILHASDHQMKNTIRPIEPAMGVDQFYFDKACEYFRSL
The following text describes a protein:
Function:
Involved in the biosynthesis of 3-amino-5-hydroxybenzoate (AHBA), a compound that then serves as the starter unit for the assembly of a polyketide during the biosynthesis of rifamycin B and other ansamycin antibiotics. Catalyzes only the phosphorylation of kanosamine to yield kanosamine 6-phosphate.
Sequence:
MGTPYHLGIDVGGTKVAFRVESGSACIEETSFSWGARHSAEDDLAQLAGHVARLRERIGTPLEAVGVAMPGTVGADGRVATWPSRPEWTGVDLKTALHSLFPEAAVAWADDGDLGALAESRASGCENLLYIGIGTGIGGGLVLGGVPCPGLGRGSFEIGHVIVEMGGVRCVCGRRGCLQALASGPATLRRASLLRGADVTYYRLQRALRNGEPWAADALEGSTRALAAAVTGVQELVHPDRVLIGGGFAAGIPEIVPSVSGFLADLVRQGQAPLPVEPAALGGLSSLRGAVALAGLVAAGEVP
The following text describes a protein:
Function:
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTLKSPSCLIFLLLFLFSSTVNSQKLAVVVIDGLAANTFYKFSHLSVFRTFEEEGVWSTKVFPVFPTFSISNRHSLLTGTLPRRHGIIGDYINNWKDNLKFQNFTADSDFSRDWWSIDPIYISALRSSASVAMFFFPECDVDWDVAPQICVPPRTDGKTFADESQAKRVIQATREHDLTLIYHPWIGEEIRRKGVHHTNEKHSKEVLRFAQSLERLTAQARERVDLNVIVVSTHGFIDVPRKNIRVMDEYVPMELIETTVGSGAIKQLQVKKGKTHQVYSQLHDHNPIPNVHVYYTTPKSGNLPDHYHFKKSDIVADLVLLADPGYAVVTKDEKKQFPKPKLQEITAAIDGYNNELPDVLGVFLGYGPAFRVGFRKGPIQLFDVYSLMCSLLSIEESCNHTPGRILRIDDVLTSDARVSIRNPISLISTVFSVILVILFSVVRSVY
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEEIPSLVIDPGSCWTRFGYAGEESPMTILPSYYGVRSDVTGRNKYVVDELQIHAPIPGMEVKNGKSNGIIQDWESTLYTWERGLKEKLQVNPTEYAMMITEPSWNPQSVRQQIMEAAFEQLHVPAFYLTKQAVCVAFANSKSTALIVDIGSDNASVTPVVDGLIIRKGIFKQSLAGDFLNANIEQLFNTMNIEFPPHYRIARKSVAIQQSGNMANGSADAVKPAVLYPPIQDLTSSYEIFQKRRVIEEWKESVLDVLDTPFDEAKASSRNPKPFEFPDGVTHKFGQERFRISEILFNPSFSASRSAETTPPQGSVGLHELVYQSILACDSELRSPLLNNIVVTGGTSLIPGLSERLQAEVQRLATGSRINVHTAETASATSNAVWFGGSILASLDNFQHLWVSKQEYDEVGVDRALFVEKRCK
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MFLIQYWVQQEILSPELLPYFDVSKIQDALKGQLDSIQDLKKDLSKHNKQRDTQYLTLHVIELERIQYFYQQYLRTRMLKLISNAFYYYNNIGEYQISLKEKEFLKALVEKKLTIYSQIKFWSEIGQSKLIIQSQQDDKINVQKPDVNQYVVIHVNTSRTIHVGSIALSENDSALVSYDDIKQLSYVILRFMVPIKSVTLI
The following text describes a protein:
Function:
Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation.
Subcellular Localization:
Nucleus.
Sequence:
MMVEPGQDLLLAALSESGISPNDLFDIDGGDAGLATPMPTPSVQQSVPLSALELGLETEAAVPVKQEPETVPTPALLNVRQPPSTTTFVLNQINHLPPLGSTIVMTKTPPVTTNRQTITLTKFIQTTASTRPSVSAPTVRNAMTCAPSKDQVQLKDLLKNNSLNELMKLKPPANIAQPVATAATDVSNGTVKKESSNKEGARMWINDVKMRSFSPTMKVPVVKEDDEPEEEDEEEMGHAETYAEYMPIKLKIGLRHPDAVVETSSLSSVTPPDVWYKTSISEETIDNGWLSALQLEAITYAAQQHETFLPNGDRAGFLIGDGAGVGKGRTIAGIIYENYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLNKFKYGKISSKHNGSVKKGVIFATYSSLIGESQSGGKYKTRLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGEGTPFREFSDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNKAVKLWVIARERFQQAADLIDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVKRVVQLAREEIKNGKCVVIGLQSTGEARTLEALEEGGGELNDFVSTAKGVLQSLIEKHFPAPDRKKLYSLLGIDLTAPSNNSSPRDSPCKENKIKKRKGEEITREAKKARKVGGLAGSSSDDSGSESDASDNEESDYESSKNMSSGDDDDFNPFRDESSEDDENDPWLIRKDHKKNKEKKKKKSIDPDSIQSALLASGLGSKRPSFSSTPVISPAPNSTPANSTTNSNNSLITSQDAVERAQQMKKDLLDKLEKLAEDLPPNTLDELIDELGGPENVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQADRRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRATESRDLSRFNFDNKYGRNALEIVMKSIVNLDSPMVSPPPDYPGEFFKDVRQGLIGVGLINVEDRSGILTLDKDYNNIGKFLNRILGMEVHQQNALFQYFADTLTAVVQNAKKNGRYDMGILDLGSGDEKVRKSDVKKFLTPGYSTSGHVELYTISVERGMSWEEATKIWAELTGPDDGFYLSLQIRNNKKTAILVKEVNPKKKLFLVYRPNTGKQLKLEIYADLKKKYKKVVSDDALMHWLDQYNSSADTCTHAYWRGNCKKASLGLVCEIGLRCRTYYVLCGSVLSVWTKVEGVLASVSGTNVKMQIVRLRTEDGQRIVGLIIPANCVSPLVNLLSTSDQSQQLAVQQKQLWQQHHPQSITNLSNA
The following text describes a protein:
Function:
Exhibits calcium-dependent phospholipid binding properties. May function in membrane trafficking. Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole. Affects directional sperm motility.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner.
Sequence:
MNQPIAAIGISDSTRPKTNVRLTISAEHLMDTDVFSKSDPICLVYEKTSGKKATTTEPVQVPTWQDSQWTERGRTEVVMNNLNPQFTKTFLLPYFFEETQLLRFEIYDADSPNVGQDLSPHDFLGRFECVLAQIVSYSTLKAHLGKAEGIGAQWRNKDKNTRTGSITIRAEEDEKCEKIQFDVCGEGLDKKDFFGKSDPYLNFKRKFDDGSAHLVHRTEVKQKTLDPRWATVQINTQTLCGKDGERPIIIECYDHDKWKKGEEPRGEAKFSRDDHIGTAHTTLNELLRGGAGDPVELLLTNEKKKAKKGDKYKCSGTLKIWNSKIIVEPTFLDFISGGTQLEFAVAVDFTASNGAPKNSSSLHYMSADRPNQYELALRSVLSICQHYNSSKTFEAFGFGAKLPNSVSVSAIFSLDLLRGTPEVVGISGVMSAYRHALQNVQLYGPTNFAPIIDTVAQKAQNMIHDSARYQILLIITDGIISDMHATIRSIINASGLPLSIIIIGVGNEDFEKMHELDSDDSLLQQDSRIAQRDIVQFVTIREFLNNGRGVYLDPDVVQENLAREVLFEVPGQLTGYMKQRGFQPRPVENPWTRNSPPPDYDPVLDGIGRRAQAPSPGFQMPVASAPPMY
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSMAAALAASLPAAVSTQATPQPAAQQPSKVPQRLEGVVDVEAAREVENVSLSSLVFLKMMKHSTDSLPAPPASVLQQDRNPPPSTELSSHVDALGVLLGLDLDGVMEVEDCYALPGGETSLGPNSYSAKLLSRLGTVSTPDSPVGIYLSTHNGGFATRVSIELLSAVEKAAGRGKAILVVHDASRSNGGDVSVKAYRLADGAREAAKLGRWDGQVLIEQGITASTLLTSIPITVTSPSLVNAFISTLNTPSPSETSAPSLTNPSVPLPPSFAPLINPLPGSLTAYLQNTLDALTLHSHEANNIAFLTRQIAREKTKHEQAIRDREEENARRRKMGLSEFPSIPQEIRGGTKEPSRLEMVCLGGTVEGIAKGMAAEAGKGLVRAYL
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MIRIAAFLTLLAASCLGESCTDPVITPSAYTTSDAVISSESVFIVELGLTCANGAQTVTLYADVNGRQFPVTRGQDVGKYQVSWSLPHKQASSGTYQVKFFDEESYSALRKAQRNNEDVNAIQPLFSVNIDHRGAWNGPWVSTEVVAALIGILIYYLAFSAKNTIQA
The following text describes a protein:
Function:
Acts as a zinc chaperone in the AztABCD zinc transport system. Directly transfers one zinc cation to the solute binding protein AztC; the transfer occurs without the formation of a stable interaction. Binds 3 Zn(2+), two with high affinity and one with low affinity, and transfers only Zn(2+) bound to site 2 to AztC. Likely functions to store zinc in the periplasm and may be important for zinc accumulation in zinc-limited environments.
Subcellular Localization:
Periplasm.
Sequence:
MLRHLAGASALALTLAGAGFAQDHDHDHEDVTLYRVFVGDHEKGQVTAFDLAEPDHRWTFPTTGQVKLYSVAGGAVVAAVQSDADTVQFIRSGISFHDHGDHRDIEVGDPAAIDASLTGPRPFHLVEHDGKVVLNYDQGGYAEILDGHALAEGKAEPGRFPQARAHHGFVAPLGGNWLSTVASDEKVEGDASVPRLGLQAFDAEGNPAGNLATCTGIHGEAFSGAYLAAGCKEGVLTVKAGANGSEYKLLPYPADLPQGVTTGTLLGSTGIQVFLGNYGPDGLVVIDPVDEPHYRYIKLPFRRVDFALDPAKPSTGYVLTEDGSLHRIDLLKAEIVASAKVTEPYSMDGHWNDPRPRIAMAGDEIVVTDPNAGLVRRIATEDLSERGTVPVEGKPYNIAVTGGSGVTH
The following text describes a protein:
Function:
Hydrolyzes the bond between sulfate and the aromatic ring in a compound such as 4-nitrocatechol sulfate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKRPNFLVIVADDLGFSDIGAFGGEIATPNLDALAIAGLRLTDFHTASTCSPTRSMLLTGTDHHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGKWHLGLKPEQTPHARGFERSFSLLPGAANHYGFEPPYDESTPRILKGTPALYVEDERYLDTLPEGFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPREIVEKYRGRYDAGPEALRQERLARLKELGLVEADVEAHPVLALTREWEALEDEERAKSARAMEVYAAMVERMDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLGFLDRHYDNSLENIGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQGAISHAFATVMDVTPTLLDLAGVRHPGKRWRGREIAEPRGRSWLGWLSGETEAAHDENTVTGWELFGMRAIRQGDWKAVYLPAPVGPATWQLYDLARDPGEIHDLADSQPGKLAELIEHWKRYVSETGVVEGASPFLVR
The following text describes a protein:
Function:
Plays an important role in the degradation of dermatan and keratan sulfates.
Subcellular Localization:
Lysosome.
Sequence:
MCLPVKRQVLRALWLFAVLDTGLLLDGGMLYPRESSSREVKELSGLWVFRADRSPSRKQGFDEAWYKRRLEETGPVIDVPVPASYNDITQDPAIRDFIGWVWYERELVVPTHWIRDDTIRVVLRVGSAHYNSVVWVNGVSVTQHEGGHLPFEAEVSDVIRKDPTGSCRITIAVNNTLTLQTLPPGNIQYMNDRTRYPDGFFVQSIYFDFFNYAGIHRPVLLYTTPKAYVDDITVVTDFSDNTGLVSYIVSVKGAVTAALKVTLMDKQGHCVASSNGPFGVLKVQDVKLWWPYLTHENPGYLYSMEVRLNAADGRTTYEDVYTLPVGIRTVNVTSTQFLINNKPFYFHGVNKHEDSDIRGKGLDWPLIVKDFNLLKWLGANSFRTSHYPYAEEILQMCDRHGIVVIDESPGVGIKDIRSFGNASLSHHLIVMEELVRRDKNHASVVMWSVANEPASEMPPADYYFNTVIKHTKDLDPTRPVTFISSSNFARDKGAPYVDVICINNYFSWYHDPGHLEVIPIQLNTEYENWHGKYKKPIIQSEYGADAVPGVHVDPPVMFTEEYQKIVLQNYHKVFDQKRAQYLIGELIWNFADFMTTQGVTRVVGNKKGIFTRQRQPKAAAFVLKERYWRLANETGRLPLWTKYPCSL
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDSETTHFLSKPEASSLPCFWVSDSCSSMKGEGTTLGGKKRRLSVDQVRLLEKNFNDENKLEHERKVQIAEEIGLRPRQVAVWFQNRRARSKMKRIESDYECLSAEYDKLKSDFDSLLNMNHELKAEVDQLRTTWAAVEKMKNHFEPVGVEAMDSSVTKLEKANAKTMGEILYKVQMGSSRHEEGSLSSSKSDGFYSESPTRDNQSKSANFLQDEEDELGCLGKLEDELSANELMNSFNILSSAVENQSFCFWS
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEDLFSPSILPPAPNLSVPILLGWGLNLTLGQGAPASGPPSRRVRLVFLGVILVVAVAGNTTVLCRLCGGGGPWAGPKRRKMDFLLVQLALADLYACGGTALSQLAWELLGEPRAATGDLACRFLQLLQASGRGASAHLVVLIALERRRAVRRPHGRPLPARALAALGWLLALLLALPPAFVVRGDSPSPLPPPPPPTSLQPGAPPAARAWPGERRCHGIFAPLPRWHLQVYAFYEAVAGFAAPVTVLGVACGHLLSVWWRCRPQAPAAAAPWSASPGRAPAPSALPRAKVQSLKMSLLLALLFVGCELPYFAARLAAAWSSGPVGDWEGGGLSAALRVVAMANSALNPFVYLFFQAGDCRLRRQLRKRLGSLCCAPQGGAEDEEGPRGHQALYRQRWPHPHYHHARREPLDEGGLRPPPPRPRPLPCSCESAF
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MFLEWKVETEEDGLLLRTFLKSKHISKQLLTAVKFGADGKIEVNNEEQNVLYHVKVGDKVRLTFPTEQQNERLLAEYTNLDIVFEDDFLLIINKPAGMASIPSQYHPNGSVANFVKGHYEAQGLTNAIHIVTRLDRETSGLMLIAKNRFAHARLSTFLQKGLLKRRYQAFISGVLVEQKGSIEAPIGRKEVSIMERFVTPEGKYAKTNYEVLARYRAFDHVAIQLETGRTHQIRVHFSYIGHPLIGDDMYGGDTNLLKRQALHSCHLHLVHPLTEEYMAFDLPLPADMEEIIQKSK
The following text describes a protein:
Function:
Required for nitrate signaling. Regulates expression of the nitrate-responsive genes NIA1, NIR1, NRT2.1 and NPF6.3/NRT1.1.
Subcellular Localization:
Nucleus.
Sequence:
MGCAASKLDNEDAVRRCKDRRRLMKEAVYARHHLAAAHADYCRSLRITGSALSSFASGEPLSVSDQTPAVFLHTPPPPLSEQSPAKFVPPRFSPSPAPSSVYPPSTSPSVASSKQPSVMSTSSNRRRKQQPKPRLPHILSESSPSSSPRSERSNFMPNLYPSAYQNSTYSATPSHASSVWNWENFYPPSPPDSEFFNRKAQEKKHNSDNRFNDEDTETVRSEYDFFDTRKQKQKQFESMRNQVEEETETEREEVQCSEWEDHDHYSTTSSSDAAEEEEEDDDRESISEVGTRSEFGSTVRSNSMRRHHQQPSPMPQVYGGAEQSKYDKADDATISSGSYRGGGDIADMKMVVRHRDLKEIIDAIKENFDKAAASGEQVSQMLELGRAELDRSFSQLKKTVIHSSSLLSNLSSTWTSKPPLAVKYRIDTTALDQPNSSKSLCSTLDRLLAWEKKLYEEIKAREGFKIEHEKKLSQLQSQEYKGEDEAKLDKTKASITRLQSLIIVTSQAVTTTSTAIIRLRDTDLVPQLVELCHGFMYMWKSMHQYHETQNSIVEQVRGLINRSGKGESTSELHRQATRDLESAVSSWHSSFSSLIKFQRDFIHSVHAWFKLTLLPVCQEDAANHHKEPLDAYAFCDEWKLALDRIPDTVASEAIKSFINVVHVISAKQADEHKIKKRTESASKELEKKASSVRNLERKYYQSYSMVGVGLPESGPDNQHMLDARDPLSDKKSELAVCQRRVEEEMVKYSKAIEVTRAMTLNNLQTGLPGVFQSLTSFSALFMESLQTVCTRSYSIK
The following text describes a protein:
Function:
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
Miscellaneous:
MISCELLANEOUS: RraA and RraB interact with Rne at separate sites within the Rne and exert distinct effects on the composition of the degradosome, affecting distinct sets of RNA transcripts.
Subcellular Localization:
Cytoplasm.
Sequence:
MANPEQLEEQREETRLIIEELLEDGSDPDALYTIEHHLSADDLETLEKAAVEAFKLGYEVTDPEELEVEDGDIVICCDILSECALNADLIDAQVEQLMTLAEKFDVEYDGWGTYFEDPNGEDGDDEDFVDEDDDGVRH
The following text describes a protein:
Function:
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Subcellular Localization:
Cytoplasm. Lysosome.
Sequence:
MEGADASRSNGASPEARDARSPPGPNGSLENGTKADSKDTKTTNGHSGEVTEGKTLGSALKSGEGKSGLFSSNEWRRPIIQFVESVDDKGSSYFSMDSAEGRRSPYAGLQLGASKKPPVTFAEKGELRKSIFSEPRKPTVTIVEPGEARRNSYPRADSSLLLRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCDLHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIVDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNNYTSSYGNEWSTPDTMKRYSMYLTPKGGGRTSYQPSSPNRLSKETNLKNFNNLYGTKGNYTSRVWEYSSTVQNADDMPTVQGNSSFSLKGYPSLLRSQVPKAQPQTWKSGKQTLLSHYRPFYVNKGSGIGSNEAP
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MPEMTDVESGVTDFAASGRAGRRNALPDILGSPAGGETSDLPKKLAELSLSEDGGGEEASAEAPPENQEKSEET
The following text describes a protein:
Function:
Transcriptional regulator involved in phagocytosis and pinocytosis. Both activates and represses transcription. Regulates expression of acaA, carA, pkaC, csaA, cotB and lagC. Promotes amplification of the tRNA gene-associated retrotransposon TRE5-A, a mobile genetic element formerly called as Dictyostelium repetitive element (DRE). Suppresses agnC and agnE encoding argonaute proteins which are part of a RNA interference pathway controlling TRE5-A amplification. Required for amplification of both sense and antisense RNA transcripts, but does not activate their promoters found in A-module and C-module of the TRE5-A, respectively. Nevertheless, binds to distinct DNA sequences containing A and T stretches within the C-module in vitro.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal domain (724-998) alone is able to regulate gene expression. The C-terminal domain (724-998) is required and sufficient to maintain high steady-state levels of both sense and antisense RNA transcripts of the tRNA gene-associated retrotransposon TRE5-A; A.T hook involved in DNA-binding is important for the gene regulatory function in vivo.
Sequence:
MEELIKAPNSNFIIMSNQPYQTTSPEIVEDYIIKRGQPFVLTGTTQGWSRSNMFTLDFLSERYSEMELINSPRNNETHTDLQGWRMKDFISYLQVSPEERNPKHLYGKDIACPREWQEYLSHKLQPQYSYKSRFDLVSHLPDYLQPETLLVYIGSNGTYTPGHIDMCGSLSQNLMVSSDQDAFAWWFIVPTEYKDEALKFWGDKGGDVYNESRFIRPIDLLGAPFPIYVFKQRPGDFIFVPPDSVHQVVNCGPGISTKVAWNSISLKSLPISYFSSLPHTRRMAKPELFRIKAIAYYTLRKIMGDVENTNFNTIDVNDVIDIIAPLLEIFHNILQTESILIPKPNYPYCNGETIPFLQPFKYFNGDRIQDRRCDHCNSDIFNRCYHCETCKTDDGQGKDFCFDCVSSGIGCEFHFKVMVLKEFISHSKLKKELSSFYEIYKNLLAHSGRRPKEVDDIITKSTDRVSDECGFLTTATVAYHVVFYSSQKKIKCHRCEKRFKKFSIIFCTNCNARFCEQCVVNTFGQNFQVLMKRNEWECFCCKGLCDCSNCTSNSNSSNHPRILNNNQQLGLPYNNNNNSNNNNNNNINNNNNNNNNNINNNNNNMNNNNSINNNNNNNNNNNINNNNINNNNHHNNNGNNNLNSSYSSLNALSSLSQQQSYGSYDNYNNNNNNNNYNNNNNNNGHIQILKSGRQYDDEQSSSSGSGSSNSTPTKPRPRNGGDDGLMSHFSGNNNNNNNHHNNNNNNNNNHHMMSHHHHNNNNNNNNNNNPTTSSLSSLSTSLSSSSTSTQKPMDVHSKKRPIVLDNDKPKGRPPKNLKEWTSTHKFIISLIELFRSSNNAILGKPNPHYKPIENLPPLVQLYLSQRKAFGGVLWAKTNSCPLLPCIWVKDLSVIPPNTKLLPSLIQGKKIVVLFFGDQDQEEYVGIVGKKSIFSFDEVNQTLLLKCGEVPLAQLEDLFNTTEPEIAMKKDIAAFNYKNQIEEKEEGLYVKQELYNNKKII
The following text describes a protein:
Function:
Required for uptake of DNA by competent cells.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes mostly to the cell poles during the development of competence, this depends on comK. During competence a number of proteins (at least CoiA, ComFA, ComGA, DprA, RecA and SsbB) are thought to colocalize at the cell pole, when comFA is disrupted ComGA no longer accumulates. Colocalizes with CoiA and DprA. During development of competence ComGA and SsbB colocalize in discrete foci which accumulate at the cell poles and then delocalize without the overall levels of proteins decreasing, these processes are coincident with the timing of transformability and the site of DNA uptake.
Sequence:
MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLKKRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEESLVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQYAKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRDAETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDLACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIRKGIALGYLTTNNYDRWVYHEKD
The following text describes a protein:
Function:
Has antiviral activities.
Subcellular Localization:
Secreted.
Sequence:
MTFKVNQPITWDIYRKGGAQQLIFTMYAFGFIQIGFILLCTITISSLTCNHLPLQQRRVIESSLQLLDKMGRRFPQQCLREKMSFRFPEQVLKPRQKETVKVAIEEILQHIFYIFSKNLTLAAWDGAALEQFQNGLYQQIEKLEACIIKKQTQYFWSKEVNRLKLKKYFQKIDSFLKEKQHNLCSWEISRAEMRRCLQLIDKVIRKLYK
The following text describes a protein:
Function:
Participates in transcription termination.
Subcellular Localization:
Cytoplasm.
Sequence:
MTIRLSDEARQLIAVFETETDATAVDCLPDDDRVVYVVTAGEMGAAIGDGGSRVDALEATLGRSVVLVEDAPTAEGFVANALSPAAVYNVTVSENDTTVAYAEVAHEDKGVAIGADGTNIETAKELAARHFDIDDIQLT
The following text describes a protein:
Function:
Possible negative regulator of polyubiquitination (By similarity). May modulate the activity of the p38 MAP kinase pnk-3. May have a role in axon termination and synaptic transmission at motor and mechanosensory neurons. Plays a role in intraflagellar transport in cilia and cilium length regulation.
Subcellular Localization:
Nucleus. Cytoplasm. Cell projection, dendrite. Cell projection, axon. Cell projection, cilium.
Sequence:
MSDQPGTSRPPLRAEPTPTKTATRRRARPIAIPSDETPRNEVTFLRPSEVPQRKPLPEYREPQPRKTVPKNVPLEDLHNYHREECLNVSIPHFINTEDLIKESQRVNGLISFRSTNFVDPSVILKEIKKKEEETVTLMDNDKNSIIDIVGDGINYEKLKKVEKSLCQIDIITEFMNRSRHLQGKKVNGCIMRIDETKQLLFHVIIDGPVGSIYEGGTFFADINIQPYQNHSLIPRVCFHTFIFHPNLGKYGNWDMRGIQWERRSNLEVLYNFIVEGMRNVKYDIERRNLAQLEDMSQPNISRLAKEDWPKFERTAREFVMKMAGGTINGRKTIFAETKKRRRQDFLDEDIDVIGIS
The following text describes a protein:
Function:
Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Involved in delivery of substrates to the 26S proteasome. Also required for membrane fusion and sporulation.
Sequence:
MDREDILKEFCNRNNIDVSQGRFFLESTNWNYELATALLHEVIPPEEDHGLQPSSDVSKVPEVTGSSSGISGGDQQPPRPLQRQQNTQGQGMKSGTASKKFATLRDLEGNDESAEEKSHLFTGGEKSGLSVEDGDPDPKKQLVRDILEKARQHTISPLDEQDSGPSSLASSWASVGQRLGTENEASGSTTPVTQSGPPRENPPTESQPEKPLRRTLYFWRNGFSVDDGPIYTYDDPANQEMLRYINSGRAPLHLLGVSMNQPIDVVVQHRMDEDYVAPFKPFSGKGQRLGSTYMQPRMSQMPGGLYTDTSTSSSVPINVKPNSTTPHASLQIDENKPTTRIQVRLSNGGRTVLTVNLSHTLHDIYEAVRAVSPGNFILSVPFPAKTLEDDPSVTVEAASLKNASLVQKSL