lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular Localization:
Secreted.
Sequence:
MPEGDRQLLLAKVKEQIIEALGSPPPQPTNSSPTPSAYLEGPVQRMLHKRHSKRHQDNMEDVSQVILFPSSDVLCETTQTGANEEGSENSFTYVFRPSPHIRTRRVSAAQLWFYTGHPAAEESAMLKNVSSSMSDQMGVEPTLETLGSDQLPPSTGAAQKPHAVTAAPLDVATEVADTVGHAVDLQVLSEHEPVTVATTKVQRVDDWTVFHLAPAFLNLVTREIFVLLVHCPTCPCSDQPEHTPFITFSTHPTQRNRRSGVPWSPSALEFLQRPPESGAGSDHCHRGSLNITFEELGWGQWIVHPGSFQFHYCHGTCSPTHGLTPALHWGHCCAALPSTMKSLRVTTTTDGGFSYRYETVPNILTQDCACS
The following text describes a protein:
Function:
Required for bipolar spindle formation. May act as a regulator of the p34cdc2/cyclin B kinase. Required for full activation of the plo1 kinase. However, in cut12.1 cells at restrictive temperature the H1 kinase does rise concomitant with entry into mitosis, indicating that cut12 is not required for activation of p34cdc2/cyclin B. The cut12.s11 allele may promote cdc2-independent phosphorylation of SPB proteins thereby overcoming the requirement for cdc25 in cell cycle progression.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MSETLNTPPTYAWVLKAFSSKLAGTVTKPVTKMSSYIEDAESDAELPQDAKEDLRPTETLTPLKSKAAQNGILKTPGTLQIKKTVNFKDISKDAATWNRPTKNNFLFTRLDDENPLMGHEEFKSPLLQSTPKPNINNPDNENKSKHDEFDNRYNININESYKNETKSNQRLGEDVPSKKKYPHSMDAEISKFKWDSNNNNDWSSLMKDCFRDVVNNNRKMKEIIKDVMIDTSQAFPSESLDEPDYTINLDAPRSSSGKYWKQKFSMLDSAHSDLELELTSIRERLESLILEKQEEINFWKQRCRALETEKIHNHQGQQSKYKGKEFVGNRFSQMRELYTAKPSPITTKVVSRPSQSDVREPQEQVPSKNLHRGADMSHLAAQMLTHSSKKSHTTNLIPSEGIISSTPISAASKVRMNLMQSNQTPTPAPFSIAAKKSHLPSKLSFPQDGGSLSSATTLQQLPKARVTPNVLSSLSSNLGKTNPTSVYQSKANVTTSADVEKPQVKVATSSRVDYDLKSPNQRTANAKKRLEERRRRRKLKLQELQLNS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
ADSLRRFEPNSPRSSPRGNRSPVVPRQQDSTGTLKTTISLGKTPTIVHTGPFYLHKELPGDTDLTGATNLMAHYNLEHSYNKFSGKKFKDSLSSFLPGLPGMIDTPGNTDNSSLRSIIEKPPIGGKELAFLNSSQLAGFRLHPGPLPEQYQTSSLAPLKKKQKHKKHK
The following text describes a protein:
Function:
Binds arsenite and regulates the expression of arsenic efflux pumps. In vitro, also binds antimony and bismuth, but not arsenate.
Sequence:
MPSPAEVFKCLADETRVRATLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPALPAWIHEVLQVTLRANGDWLQADAARLRDMDGRPQRASACCQ
The following text describes a protein:
Function:
Regulates pharyngeal pumping during feeding.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MTTFCRVLLIFGIYVAVCCAQSVEDDVFHFTNPSQGNAVWILDESSLPWTGGYQFLRSISGMPTTLLSVVDSSTGVTLGQCVAPQDATGNFSKRWERFSWELTASGLDCTFEHGAAIRVEFDRTQNPRTFSIRIQSITGPACLRDVVVQTEQATGCPPHLSRNSFTANALNCSCPFLDAANEDSEIENEDVDMLANTPQFPLFKGIDPSVLGSANPPTLPPSPCANHECHNNGTCLVSQEGAATCLCRNGFTGDRCELDVCSSVPCQNGGVCRSNNGIAYCECPPAFTGLLCESAHTDESVAPICRPECSNGQCVFKDGQAQCECRQGFTGANCNVLDVCLGDAACSMFGPLAKCVLDDNMDKMSSLTLINGTYDCLCPHPIHGQFVDCMQLHAPSATSVQPTEQVVINNVTPSFPVLEISKLPTGAPVTFTATSTTLMVTQPTVTVSPTHQVPSEPFVGFTVTRAPLRPLDIGSTTLPPPFNQHIITAGEPTWSSQQPHQPSEVPTQTTFIFPQTPETTTFAPTTGTQQPVHKFVSPSVPDENEEEEEEETTEETEETFPTPSTMQVATNGQFTTETAFVTSTIPSTTTDMEETDEDEDMTEEVTDSSTQPSTTVFVQPTTTFTTEAPTTTMEEEEEMTTDQVEDIESEEIATTTTQTSLPFWMTTTNKQVVPDSPTPMVIMPHPQPDEKMETSTEGVVDEESDEERTTVPESNEEVVTKNAEATTPSDITHHHTSSGKQSSAAASWIIAIIALIVLGLLLLATSLFILRYIRQSRKLHGKYNPAREEHNLSAAYAMPMSHIAKEERLI
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDQEKEEVSFRKKLLDIIETLTDIENISELEEHLPHLHGLGWDEVIEERFVNKQCGFPACSQNPPKKTKTQMFQIDKKEGKIYEFCKQRSKFCSEKCYQKNLFVRNQLDEHPLWITGMTETRMNKKYEVPDETFVSPVAEKVEKEKESIEFVADSIINLKLNEEYQEPKVLESDEPEKEPYKLTEDDKEFIKSIKQFKTNNFGPAKDPKTAPKKTPQPRLSEKNLKKEEEILAKLREKIPSESQACPIVTFAPPVNEKYAWLLDLMKSWITEETRRLTREGPRSHGGDVEQILMDFLSGKKIDAEKLVDLPNLDKYNVKEKRLNIFLHSMRHHWADLEARLHLTPTRRDILTRVAATFHLNAENITGWNKKELNTISIAMFLLICLVDVELGDDFFKKDHPSPELSTVSIDLCDIDSSELTGLYEAIKAQCAC
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.
Sequence:
MSGRLWSKGIFAGYKWGLRKKREHIAFLKIEGVYAPDETKFYLGKRCAYVYKAKNNIVTPGGKPNKTRVIWGKVTQAHGNSGVVHAKFQMTLYTTRV
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-lipid IV(A) to form a Kdo(2)-(acyl)-lipid IV(A).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MDRPRFSSAFLHPRYWPLWFGLGLLWLVVQLPYPVLLMLGRGLGALMYRLVGSRREIAARNLELCFPEKSPAERERLLKENFASSGIAFFEMAMSWWWPKARLARLAHIEGLEHLREAQAQGEGVILMALHFTTLEIGAALLGQVHTIDGMYREHDNPVFDYVQRRGRERHNLDATAIEREDVRSMLKVLRGGRAIWYAPDQDYGAKQSLFVPLFGIPAATVTATTKFARLGRARVLPFTQSRLADGSGYRLTIHPPLEDFPGESEEADCLRINQWVERCVRQQPEQYLWAHRRFKTRPPGEAKLYPKRRKR
The following text describes a protein:
Function:
Required during eoplast (a highly reduced plastid type present during the degreening and dehydration stages of seed maturation) development in embryos and early stages of eoplast redifferentiation during seedling growth.
Subcellular Localization:
Plastid, chloroplast membrane; Peripheral membrane protein; Intermembrane side. Plastid, chloroplast envelope.
Sequence:
MRALNSRLVLIDINSSWQASRRLISATATAFSSDSSSSFRRTRGARQRIASSKSPASSPSPVRRPSDGFSFDVRSPSSDSSISSRKSPTTAPPTVELDAFLEILPPATRKELVKHEAIEELIEVVMDLGRKPLARFPSGDWVISEQPVTHQDLELAVSKVGDFSDDNRSGIDRSLHRISAIRNRKLQVIGLTCRVGRVVSGSAEIIRDLIEGGGSILVIGSPGVGKTTLIREIARMLADEHRKRVVIVDTSNEIGGDGDVPHSGIGRARRMQVPNVNLQHDVMIEAVENHMPETIIIDEIGTELEALAASTIAQRGVQLVATAHGMTIDNIIKNPSLQILIGGIESVTLGDEEARKRKVQKTILERKGPPTFTCAVEMISRTECRVHQRLDVTVDAILAGKSAPFEIRQIRGEDDVPHKLVTPIPLENLEEEPAPLLNRDFVSELLSDDEDEDFLLIRSNKARSNTYTSPRSSPVHVYTYNVLEADLLQVAEVMGLDDEIEVTDDVGEADVILASSSELKQNSSIRRVAKLHKLPIFVIKSTTMAQMVKAVRMILGRESFGSAPKAIEKSSVDDIEIKDDAPESKPSLEELDALEEVRLAIEYIVIPGGEPVELLPRRSDIIVRQLELVESYQLAVENLGTHLNPRLQILPRRSTKKTLTSSSPQKSADGSMGTTGTRLPFLKD
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MGTPSDRVPLAERVEELLAVGGPLPIVAAGDPVLRRAAEPYDGQVAPALFERFVEALRLTMHAAPGVGLAAPQVGVGLRVAVIEDPAPVPDEVRVARGRVPQPFRVLVNPSYEPAGAGRAAFFEGCLSVPGWQAVVARHAEVRLRAHDEHGRAVDEVFAGWPARIVQHETDHLDGTLYLDRAELRSLASNAAMAELWSQPTPRRAASALGFELPGPAA
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNRQQLCRRLYFSRSATAFPSTRIAARSITTASPASPASPASPSTAPSTFSTINASEISHFSKLSSQWWSETGEFALLHRMNPVRVEWIRQKVALAPPPEEEWSFETRHMDAQREAARGTGAWLTGLRCLDVGCGGGILSEALARLGATVVSVDASESNIGIATTHANQDPYLAKKMEKGELEYRFSTAEALRDAGEKFDVVCSMEVLEHVDEPGEFMKCLGEMVKPGGHLLLSTISRTPLSHLLTITLAEDILRLVTPGTHTYRKFIKPEELRRFVYSDMGGFKTWHRNDDASDIRENEVGETRGIIYDPLKGAWRLWDGVEGSWWKEAGEVCNYMYHAKKRS
The following text describes a protein:
Function:
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MNNQHMLRTTVFITAFLWAAASCGSPSAMAGGLKLGDLCRLKGQETNTLQGLGLVVGLQGTGDGDAAPKGRALARMMQLMGGPMAVDAAGRLNIEDVGDAKNVAMVFVSATIPTVGAQQGDVLDVTINAISAKSLDGGYLMLTPMLGPRADNPTVYGMAEGRISVSADSPPTSATIQGGLKMETSVRASYVHDNRITLVIDRDFADFSTAHMIEEEVNSLTSFTIGDRNVSRLASPNHQGTGQDGNIALARAIDQLHVEVVIPPTYRDNPIKFIAFLLDIVIPLSNRGKRVVINEADGVVVIGEDVEIAPVLVTHRNLRIEAGGGGRFVEVGPDGTPAAAKLKSLADALGALDVPTEDLIAIIKTLKAKGDLYGEVIFR
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Has a broad specificity for nucleoside triphosphates, being highly active with ATP or dATP as phosphate donors, and less active with GTP or UTP.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. The LID domain is a solvent-exposed domain that is much shorter in Mycobacterium than in many other bacteria like E.coli.
Sequence:
MRVLLLGPPGAGKGTQAVKLAEKLGIPQISTGELFRRNIEEGTKLGVEAKRYLDAGDLVPSDLTNELVDDRLNNPDAANGFILDGYPRSVEQAKALHEMLERRGTDIDAVLEFRVSEEVLLERLKGRGRADDTDDVILNRMKVYRDETAPLLEYYRDQLKTVDAVGTMDEVFARALRALGK
The following text describes a protein:
Function:
Involved in vacuolar trafficking.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLSFLLFSPFLPPCFSSISICLSVLSTVSFFFAFTIPHYVLRCGSVDEWHIHSSAEDFRTQRCVCAVKLSASLLGCLLACASWSLLLEVSRIKWHVGTAYS
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular Localization:
Cytoplasm. Membrane.
Sequence:
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMSNVTLDYCLDVIKKFEVSEENKVKNVLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFKDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKLDLSSVDTGECRQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLDSLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQNLDVKESGKKSHGRSLMANFGKHKQKTPKSRSKSYSTDDEEDTLQNPGKEGGQLYRLGRRRRTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKGTFNPLSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIFGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHGSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKVGFQEMVEIKDSVCEATRDQDGVLRRTTRSLQLRPVSMPVDKNLLGALSLPISEAAKNTDGKENYLVQI
The following text describes a protein:
Function:
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Sequence:
MAAVNGYQGNTPADPPASNGSKQPAAPTKTVDSQSVLKRLQSELMGLMMGGGPGISAFPEEDNIFCWKGTITGSKDTVFEGTEYRLSLSFSNDYPFKPPKVKFETCCFHPNVDVYGNICLDILQDKWSSAYDVRTILLSIQSLLGEPNISSPLNTQAAQLWSNQEEYRKMVEKLYKPPSA
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSSPSLVELKAILRLAGPLIAAQLAYVAMVFTDTVMMGKLGPDALAAGGLGAVSYAFVSTFCVGVVAAVGNLVAIRHGCDDAAGAAAAARSGLWVGAALALAAGLLLWNLRPLLLVFGQAPQTVDGAMQFLHSLTFALPGYMAFMVLRGFTSAIDRAGPVMAISVLGALANLALNYSFIEGLFGLPRLGLAGIGLVTALVMNCMPLLLALYIRLQPAYAEYSLLRGLGRPQRAMVEEILRLGLPIGGTYAVESGMFTVATLCMGIIGDHALAAHQIAIQAVYVAFMVPVGLSYATTYRIGQHFGAGRLLEARRAGRVGIGFGALCMLLFAGLFWWMPEAIIGLFLDRDAPANREVAAMAVSLLAIAAWFELFDGTQNVAMGAIRGLKDARTTFLVGLACYWLVGVPLACLLAFAAGWGAAGVWWGLAGGLACAAIGLTLAFEWKTARLLPKATASEASALNCRAAGRGAPSARLCPGNAPVPPTAAAD
The following text describes a protein:
Function:
Methylates precorrin-2 at the C-20 position to produce precorrin-3A.
Sequence:
MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD
The following text describes a protein:
Function:
Involved in the replication of mitochondrial DNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MSNRRLLLRGITRSHRSFVTSLRRRQQQQQQQQSSQQLQQQHPLQQFTEEPRVNQLGIQYLSNDLHKKVFPTTSTKDYLSPQHPQLLEISKKHLQENELLGKKTQITEPITIKNFPSLVGKSMDEHFNKLGQKSSDPYLAMATNFLKKELPCKPPKSQWKFQSGWTRYTKDGNPPEQVPYPLEDTLVFDVEVMYKISNYPVMATCASNEAWYSWVSPALLDWEKQKNNSITTDQIDWNHLIPMNCAKKPKVIIGYNVSYDRARILEEYNIKQTKAFYLDGMSLHVATSGICSRQRPKWAKYNKVKKLSQEDVDEIEGTMEEEEEEEGEMSQELGQLSSESNDVSDYAKLLSDGFQVAVELEVADDPWLLMGAPNSLANVARFHCNIHLDKTDRDYFATEDPNLVIDNFPKLMDYCAKDVDATFEVTKKLFPVFIQRIPHPVSFAALRLLGTLILPTTTKWPKYIEAAESLYESNRQEVATTLQQLANDLVAHIQNKKQVKPDYENDPWLSQLNWKLKETRLKKDGTPYKKTAYMTGYPEWYRELFKTSKGEEMNLTLKTRITPLLLRLKWEGHPLFWVDSQGWCFKVPFDDDNEIARLTEKKYVQPKLTEEELMETRDALLTKGKSYVLFKVPHPNGPSSRCTHILSKLYVRNFEDGTLTSEYDYATKILNLNNEASYWLGNRNRIKDQFVVYNQQGKNKFFDTIKKSKEHSSMGIIIPNLATMGTITRRATENTWLTASNAKKNRIGSELKSLVEAPKGYCFVGADVDSEELWIASLVGDSMLQIHGGTALGWMTLEGEKSQKTDLHSKTASILGISRNDAKVFNYGRIYGAGVKFATRLLKQFNANITDEEADKVARQLYDSTKGRTAVSKYLPSRIYYGGTESIMFNALEAIAQQEEPKTPVLGASITDALNVKNLNTNQYMTSRVNWTIQSSGVDYLHLLIISMEYLIEKYGIDARLAITVHDELRYLVKETDKYKAALLLQISNIWTRAMFCEQLGIKEVPQSCAFFSEVDIDHVLRKEVSMDCVTPSNPTPIPLGESLNIGQLLSKCQHGDILADKNTKPLTLRTTKYSPRQPIINQLDKNLTIAEKIAKIELQTSIDKDEWKKNLYNLAKVSRNKQNGKNNSTEKPQRVIKRKPIVEYDLQEDNNKKREIKYKKDPPKSKIATTTTTTTTKKASSNNSKTKSNVKVDESKSAMTILDLKTDQQRPTYNNRKIVYIGNPQSKL
The following text describes a protein:
Function:
Zinc transporter that acts with PRA1 in sequestration of zinc from host tissues during infection. The pH-regulated antigen 1 (PRA1) binds zinc from its environment and then reassociates with ZRT1 to acquire this essential metal.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFTHLFFIGLLTKVYTETVTVLSTRSYRLATTESTPTDGTVYLTLTRQQSSSTSLNASTITTPPSNSSASVQTTAVTDCHFHNSVQYCVDGYGNEGSILPVPTNTNNLPTSYDGCHSHDGDTFCMDGDKEVQFVKLEDEDDEESSSSSGKKCHFHAGVEHCVDDNNHDAVTCERVKRDYDIPLRIGLLFVILVTSGIGSFGPIVLKQFVNLSQENYIIVIIKQFGTGIIISTAFVHLMTHAQLMWSNSCLKIKYEGTGASITMAGIFIAFIIEYIALRIVNARDTGKVDKKEIEETSSNEQSLHGISVNDKISVMILEAGIIFHSILIGITLVVTDDVYFITLFIVIVFHQFFEGLALSSRIISITNASLSTKLVMALMFALITPIGMAIGIGVLNKFNGNDPSTLIALGTLDSFSAGVLLWTGLIEMWSHDWLHGHLRNSSFVKTTVALVSLILGMLLMSLLGNWA
The following text describes a protein:
Function:
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
Subcellular Localization:
Cell projection, ruffle. Cytoplasm. Nucleus.
Sequence:
MKLAKSQGKKINNVSTRGETETGLNSISASLARSSTSPGCNLAEMLSHNEGEVQKWTSWQPFPENPLWTCVDFQIAQIGTWNNCSHCTHQPQLKSSWTDMDLPHSWRSSSFGNFDRFRNNSISKPDDSTEVYEGEPINESGEQSKTSNNGGGLGKKMRAISWTMKKKVSKKYIKALSEEKDEEDGEDAVPYRNSDPMIGFHTEKISLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEEEAAPKKIKAHRKSGKEKPKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIKNPEDRMRLLSAAENLLDEETIQEQENESMPLSLNPDISLNKSQLDNCPRDSGCYISSENSDNGKEDLESENLSDMVQKITITEPSD
The following text describes a protein:
Function:
Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides. Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH. Plays a role in the turnover of the vacuolar GSH, serving as an alternative nitrogen source during nitrogen starvation (By similarity).
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MSPTDTTPLLYSWDDQSRHQDPDWHKLRNYHGAWYRRISRRRFSQFIFAFGLMTLFVLVYSISSNLHTPTQFTGHKVRGRRGAVASEVPVCSDIGVSMLADGGNAVDAAIASTFCIGVVNFFSSGIGGGGFMLIKHPNETAQSLTFREIAPGNVSKHMFDKNPMLAQVGPLSIAIPGELAGLYEAWKSHGLLDWSKLLEPNVKLAREGFPVTRAMERVLKLPEMAHLLKDPIWQPILMPNGKVLRAGDKMFRPAYAKTLEIIANKGIEPFYRGELTNSMVKFIQDNGGIVTVEDFGNYSTVFADALHTSYRGHDVYTCTLPTSGPALIEGLNILDGYPLNTPSLAFPKRLHLEVEAMKWLSAGRTQFGDPDFLPLDHLDVVSKLLSKEFASQIRNNISLSKTYPWEHYNPSYDLPISHGTTHVSTVDSNNLAVSITSTVNLLFGSQLMDPVTGVVFNDQMDDFSIPGASNAFNLSPSPWNFIEPFKRPQSSSAPTILTDINGDFEMALGASGGSRIVTAVLDSIIKRIDMDYDIESMVASARPHHQLLPDILILESGFSKSVATRMKKYGHKVWRLKQHDTPLSQIQAVTRHHSEYYGMSDPRKYGQAAAY
The following text describes a protein:
Function:
Component of the endolysin PlyC that degrades the host peptidoglycans and participates with the holin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles (Probable). Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and breaking down the peptidoglycan layer (Probable). The small subunit PlyCB is responsible for the specific binding of the endolysin to the host cell-wall, probably to the rhamnose of group A streptococcal carbohydrates. PlyCB is essential for lytic activity, cell wall binding is a prerequisite for cell lysis.
Miscellaneous:
MISCELLANEOUS: Part of plyC operon, which contains plyCA, lil and plyCB genes; MISCELLANEOUS: Seems to be involved in the internalization by mammalian cells infected by Streptococcus pyogenes.
Sequence:
MSKINVNVENVSGVQGFLFHTDGKESYGYRAFINGVEIGIKDIETVQGFQQIIPSINISKSDVEAIRKAMKK
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVSATAVRRFGYVGAAANWLIPLAAIVNLPTRKPSEIDPLMTGVLGTYSAVFVRWSIAISPPNYPLFLCHATNCVVQAATLVRKAV
The following text describes a protein:
Function:
Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing; Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIKVIEDIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWETFKKKPDHFPFFFKCILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQPARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQSFQERRFLSQLIQKFISVLKSVPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDDSHLLVHCYLSNLVHREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVDTRESLVKFFGPLSSNTLHQVASYLCLLPILPKNEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLVTVRPTKPYGTKFDRRRPFIEQIGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYETFNIIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLKTSFPGHNVKVTVDDPALQIPPFRITFPVRSGKGKKRKDVDGEDEDTEEAKTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYISKVKNKGRTYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGSNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTSRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHHYHQTLLQLPPAMVEEGEEVQSQETELETEEEANPAQADLSSLTDATSSQESSASQTESTPNQTGASSSPEAIPTTSDITATVAGPVTVPAEANASQAVTPAPEETK
The following text describes a protein:
Function:
Inhibits protein synthesis. Does not cleave supercoiled pBR322 dsDNA.
Miscellaneous:
MISCELLANEOUS: 2 forms exist, PD-L3 and PD-L4, that differ in their post-translational modifications. PD-L4 is not glycosylated.
Sequence:
VNTITFDVGNATINKYATFMESLRNEAKDPTLKCYGIPMLPDSNLTPKYVLVKLQDASSKTITLMLRRNNLYVMGYSDLYNGKCRYHIFNDISSTESTDVENTLCPNSNSREKKAINYNSQYSTLQNKAGVSSRSQVQLGIQILNSDIGKISGVSTFTDKTEAEFLLVAIQMVSEAARFKYIENQVKTNFNRAFNPNPKVLSLEENWGKISLAIHNAKNGALTSPLELKNADDTKWIVLRVDEIKPDMGLLNYVSGTCQTT
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MVAFRLAKIPGALVAGATPVLGLMAFSRVQASGTKIHPSDLDIYDKPVVYNEVFLDDKRSALELKVSSGRRALWGYWDDVKVLVEKTRSAYEVVSTKSVEFVDLITNDQVFQIKFGCISSGVLVGALLAGRGRRPFRRVFYSVGLGAAVASLCYPSKATDISLEGYRKAKMFISDQWTKYQENKPKITKNPEKVLDMTSQSEGATEEKFFIVDKPVEMPETELVNEGVTPVEAVEITPSESQNSKQVSSEMAEESIMTKVPFVGWFFKSNSSNADTNDENSVVIESQEEKTQEKSDVSGKDQRMVIEPEEVKKPVKVEGDPGQSNPDDKDMYSTRS
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor. Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters.
Miscellaneous:
MISCELLANEOUS: Present with 1590 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MESTAIVPKGPVVGSEDMEKAEVIASGSTDIISTTSTATTTAAIGSVQEESVKQEDVPMEGGEGEVEEEEGETRCICGELDTPDDSGFFIQCEQCSSWQHGYCVSITQDNAPDKYWCEQCRPELHQLFTTDTGEARSIYKPVQEKRRQSRRKARSAAASKSHAANEAEKSPRNTSNTDDNVDDIGDEEDEVEDEASAVALAKDGNTRSSRRRRRNSMDDASTDQYSLDPGDSDKKLLDRKRATFMAREEKQYQRMLEKALKESRRTSHQEDPESYENDADIYQGDTDNHNGTTRLQTDVMLTEGKPDSVTNDDMKESLRPSKEQSMEKTNDVEKEASQEKESSTGSAQDTEKTDEPILPLTSISSSEDDSRKASSRGSKRVSKPARKGNRTRRSNTSSDTNQNRRSADIGTDKPVKPRLPPQRTSLNEMRRRVSAILEFISRTQWELSEDQSDREEFVRFVENQHFVEKVDTIYNGYNESLSMMDDLTRELLLWEKKYSNNTNAIQ