lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules.
Domain:
RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA.
Sequence:
MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARRPPRKFSPVLPLFPSHPPGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS
The following text describes a protein:
Function:
Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Can also catalyze, with lower efficiency, the adenylation of the toxic riboflavin analogs 8-demethyl-8-aminoriboflavin mononucleotide (AFMN) and roseoflavin mononucleotide (RoFMN) to 8-demethyl-8-aminoriboflavin adenine dinucleotide (AFAD) and roseoflavin adenine dinucleotide (RoFAD), respectively.
Sequence:
MEVSHVTLAPNKDSRAAVLTIGKFDGVHIGHQTILNTALSIKKENEILTAISFSPHPLWALKQIEIYREMLTPRMEKERWLAYYGVNHLIETEFTSRYAETTPEEFVTDHLTNLNLSHIVVGSEFNFGKGRDSDVDLLRDLCKPYDIGVTSVPVIETNQTKISSTNIRAFIRRGHFQEAEELLGHPWYITGIVENGEMTGLDDYVLPATGTYQTDSGIVNVTNNRTIEVGLSDGLQQLHMKNELSE
The following text describes a protein:
Function:
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.
Sequence:
MADPKFQNLPGIAYDQPDVYETPDDPETDTSDYYEEEPENEAIERMHISASAAHKRFSGATLEGSVDFTDRIGRRPGRGYDMRGAGEYELVGQGEKETPVQKCQRLQIEMNELLNEVAALQVDRKIADEEKQSYDAVATVISTAKKVLDTLKLEQVLGKEQVPNSKQVKALISQVEEFKQSGVLTAIPTPGTDLASTARVASLEQRLYQLEKTVGAQPEKLSRLNAATNTTNVLEAVRQLSTKAALLQPDKLDTIEQRLTTLAGKMDSIAEKSSGSSQDAKRDQKISELYDIAKRTEPVVEILPHVIERMQALESLHKYANNFAKIIAEIEHKQGTITTSLVNNKELLHSVQETFAQNLETITNKVAKVEQRVTAISTAK
The following text describes a protein:
Function:
Antifungal activity against C.albicans ATCC 76615.
Subcellular Localization:
Secreted.
Sequence:
ESAPAPEVSGDAVFSAIQNGXLKNLGNAFFW
The following text describes a protein:
Function:
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced.
Subcellular Localization:
Mitochondrion. Cytoplasm. Peroxisome. Note=Mitochondrial in liver. Cytoplasmic in uropygial gland.
Sequence:
MRGLRRGLSRLGPRLGPWAVPRSLRRVLRAAGPWRGQSSAGSVSERGGASMEEVLSRSVPLLPPYETKEKAPPPAERRSAEFVRYYRGLEAGSRRAELLGCLARDFGADHGRVAEFSAKVLQAREQEREQGALLQAEDRVRYYLTPRYRALFQHLGRLEGGLRFLVELRGDLVEGLAAKAVDGPHVKEMSGVLKNMLSEWFSTGFLNLERVTWQSPCEVLQKISDSEAVHPVRNWVDLKRRVGPYRRCYFFSHCAIPGEPLIILHVALTSDISSSIQSIVKDVESLETEDAEKITTAIFYSISLAQQGLQGVELGNHLIKRVVKELQKDLPQIEAFSSLSPIPGFTKWLVGLLSSQTKELGRNELFTESERQEISEITEDSTTETLKKLLTNSEWVKSEKLVKALHSPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAELWRINWMGDTSPRGIAASCGMMVNYRYFLEDTASNSAAYLGTKHIKASEQVLSFVSQFQQNSKL
The following text describes a protein:
Function:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes. Involved in organ growth regulation. Plays a role in plant immunity and abiotic stress responses. Required for ER stress-induced autophagy.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRGSALLDLILFLLVSPLAHSFKGSEISKFYDKSISNQISQSDRESGYVLVSTVDGSISLVDMSSQKLDWTFHTNEPIYSSYQAPHYHYTTDEERSSVLGDDFYMDCDKDWRLYNSSVRKGKRVNEIVDASEFIGTLPYTSTDRIVLGKKDTSVFLLDWKTGKLVKRYRMDELYSNTVVENDKEKAIVLSKEAPLLFGSGFKKSEDFPELVYIERKDFKIQCISKFGDVLWSVSYAKMEAKLQNHESVQFISGLSSSVGKNQFPLSYTTSVPMVQLRNVKYETLFPRLGFLDEALYLPFQDRKPNQLAIGDGNQLTLPGNKEAEEVLSLPLPETVISQITDIIDGSTKQAGFASKFSGLIVLIFGFCVTMLSVCGLFFYRLRQSIRIKEPYVSEVPIATPKKKKSKKNGTTKAVHKKENGFISGGNKDPSHEENEKRLLTAFPGLNNSSAEGYRVGKLFVSNKEIAKGSNGTVVLEGSYEGRLVAVKRLVQSHHDVAQKEILNLMASDKHSNIVRWYGVDQDEHFIYISLELCACSLNDLIYASSALLESPMASSSIHSIQINPIFENGKGVELWKENGHPSPVLLKLMRDIVAGLVHLHDIGIVHRDLKPQNVLIVKNSSLCAKLSDMGISKRLPADTSALTRNSTGLGSGSSGWQAPEQLRNERQTRAVDLFSLGCVLFFCMTGGKHPYGDNYERDVNVLNDQKDLFLIESLPEAVHLLTGLLNPDPNLRPRAQDVMHHPLFWNSDMRLSFLRDASDRVELENREEGSQLLAALESTAAVTLNGRWDEKLDSIFLDNIGRYRRYKFDSIRDLLRVIRNKLNHYRELPKELQELLGSVPEGFERYFSSRFPKLLIQVYTVLFDYCNNEEFFFKYSKTTVF
The following text describes a protein:
Function:
3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MNSLEMLGEYSSSSDEESISISKTNTASSQKSKLVVPDAICALYATEQTEHNDPTKHQGRVRSFQHVKGNWATFLYIPYPNPHCNELRSYVEDLLQFQGLDHWKIVDDFHLSVSRTSAIPHHFIEPLVEGIQGCAQKLSPVILNFSCDLKFYVNDEKTRSFCGFEVTSPFILAKLQTLVDHINKPLKDYKCDSYYENPSFHISISWTLGNIFEQNWKKQLEIFQTHWSEVFIESPELFSFEANNLVCKCGNRLFTFEISYKS
The following text describes a protein:
Function:
Cleaves double-stranded RNA (dsRNA).
Sequence:
MESPPHATASADEMPSIWKEQHAQDAPPGFVPPMGPGEVAAVESLLGYEFRDKALVEEALTHGSFYYPYRPGVTYERLEYLGDAVLTCVVSREVFLTYGQLQPGPLTRLRAANVDKEKLARVAVVHGLHHFLRHKAPNLDGQITDFIEELSMYPIHSNGLLDPPKVLCDVVESLIGAIYCDSNFNQEIVWQVFQKLADPLISLETLGKHPVSELFEFCQKTRRGVKIVKDEWDKNLTVEVLIDGEMVGRATYAQKKEIAQNRAAKAALDKLKETLGQSQTEPMSAEVSEQFNKIDLTGS
The following text describes a protein:
Function:
Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs) (By similarity). SPT20 plays a role in nuclear division and regulates hyphal and biofilm formation, which are crucial steps for virulence.
Subcellular Localization:
Nucleus.
Sequence:
MIKSEVLSGSASKTVGNSISNGTTVSTQNQGGKQNLIRQQQQQQQQQQQQQQQQQQQQLKHRTALQNYHFASTSEEILKKYSKYPASMSLHIFETHYRFNNSQDSQVIPKDSPMIKDFMKHVLKEQIPVEMCELIKDFAIRPYDGCIILQVYDHRNMVKTAVLQNRSTSSPSKDQDKKQQMVVSKPRTYRTLLRPTSLSIYYDLLYHTDSALHRFTDYLSLQMESEILTATNRELNLSVPLNPYNYDHLRPEPEPSGDMSQNSDEEIDQVKFQHRDAVEQPRRKIHQDEMVLHKSSEYEELMLLLSNKHKRPDDCSDKRLVVVSTSALPGSSLTGTSNTSTGTAAATPTPTSTTASAASQSSKQTTADGASTTDTKGKKGDKANGTSANQASASPTSVHPPIPTIPQNSVRATGQFMRLRLIEEIRKKRELEKLQQEAKIQAQANAIQSDSVPPSQQLAPQNTINSPVVTEPTKRSSPAAQNQPAPKRAKKETKKQLQAKAQAQAKAQAQAKAKVQTETPGPTPVQGQNSLSGPSVVNGSNVTSTANTPTMNNQSSLQQPSQASQPQIGSLNNNQQSQSQQQQQKNPQQTLQQQQQQQIFQNSLTPEEQKVYKQIQQNMATLAMMGQSGVTPTGQQLTPQQKQQAIQQAKNLQQQLFQRFPLYFQRMKQLQLIHQKRRLQQQQQQQQQQQQQQASNSSGGNQNNSSNQAAPQTQQFNQALPSTSEQSKPVTTSPEVKKKRTYQKKKNAPAN
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MANQDFEERSQQPQELGYDPNFVPDSVKSFVVHLYRHIREKNVYEIHQMYESSFQTLSERLFKDTPWPSVDAVAHYVDNDHVFCLLYREMWFRHLYARLTPTLRQRIDSWDNYCSLFQVVLHGVVNMQLPNQWLWDMVDEFVYQFQSFCQYRAKMKSKTEQEIALLRQFDQAWNVFGVLNFLQALVEKSAIIQILEQEKEGLEQFTATDGYDYNGGSNVLKVLGYFSMVGLLRVHCLLGDYHTGLKCLLPIDITQQGVYTSVIGSHITTIYHYGFANLMLRRYVEAIREFNKILLYIFKTKQYHQKSPQYEQILKKNEQMYALLAISLSLCPQSRLVDETVNSQLREKYGEKMVRMQRYDDEAFAIYDELFSYACPKFITPSAPSFEEPLVNYNQDAYRLQLKLFLYEAKQQQLLSGVRTFLKVYSTISLTKLASYMEVDEPTLRTILMTYKHKTHAVDSDGKITSNADLDFYIDDDTIHVMESKPAKRYGDYFLRQIVKLEGVINEMDGIKLE
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVKRNHKFKSGEGAMYYTRKAAMNKLQLNIKDFRQLCILKGIYPREPKHRARAQHGSREMKILYHKKDITFLLHEPIVWTLRDRKIFNRRIKHAAAKQNMNLRDIRLHNYPQLKLDHIVKERYPTFIDAIKELDDCMTLLFMFSTFPATKIITRELTRMSRRLTVEFMHYVIAAQALRKVFISIKGYYFQAEIKGETVTWIVPHYFPYSPHRGEMVDLSIMKSFGDFFTVMAGFINYRLYHSINLVYPPQFAHSLDSDETMGNEQKFVSERIAALNVELLRSDGGNGDTEEPELLEWTGNDEELPHVSQIRQEAQNVNKLKTLFKGLKFFLNREVPREPLVFIIRCFGGKVSWDKTMFVGATFDESDETITHQIVDRPSMEKQHISRDYIQPQWVFDSVNQRRLLPTNKYFMGAVLPPHLSPFTSANARYVPPEELAARKAAEGEEEEETFEPAEVNADHEHISDDEEVQDPENEQEMQDYALMKAFNDERTDSLNSGKKEGADDATDNGKDAAEKKQQQNGDGESDDEDEEEEDDDDGEEEEDVMPKKQKPVSNKPKGMAVRRGTVYRENEAEKKIVDKQEEALRARMVKSRHRKLYSKLVEREKKADKNARLLANKRERIEKQKRAEQMEKQKQQRKQILA
The following text describes a protein:
Function:
Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
Subcellular Localization:
Cell projection, dendritic spine membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MLIPDDAISLSPRKHATVKMAARWVISCLVVILGLCRAEQLYVLHAPSYVQFLPSASPLHTVDLPKVIGLVLGFSTSKDLEWQGLGPGSLFQRPRANFLISVENLPTGATIEPVGGVKATYPVKQTGLPDLSAVHSHIASSFPDRKSLMLDLTMDGNVFEVRPLYPGLFSELPATPQQIAVHLQKDGSVLRTERLGSLNTTKEADLIFAGELQLLQDIVNTLSGQQALVSDGVPDLVSVSLTGVGRLAQEYGPTSQQVQDAITVLNSFLPKFSKTVAELYSGNVVVEAMTLSTPTGGMQRSRRSLLQQAQDKPGNLAPKINPDYPVIFNMSLWLGVLLLLAVYSVAYNLLYMEPGRDSIIYRMTSGRMKTEDDYTRFGQGAHRPVQKWD
The following text describes a protein:
Function:
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Sequence:
MSAQQIPNLLSLRGGTRSRGRGQGLRDPLNPHSEVSSNRRDNAIQGTDTDAAVSRLSAVNLGYLEDPFARYFVNGSGTRRLPIINRGTYSRTTALDLLIESFLSQPENSAPQRKQIISLGAGTDTRYFRLRAKNLHKGVIYHEFDFPSVCAAKNRLVQQNHAELIGTERFFEMGQGDGEIAQPAMAKGVQASSEWGLGRTIDGHSEVGYMCHPLDLRKLPSIIGLDSFHGIKSDLPTLIVSECCLCYLEVDVAQDVIKWFTNKIPSIGIVLYEPVGVYDAFGQMMVENLASRGIVMPTVQKYKTLKDQKDRLVGLGFGTAEGGINAVSIENVWENWVAGRERERVDRLEGLDEVEEWLLLARHYSVVWGWTASSGFERLKALNP
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MATSVAPSEDQSRLLEEALGVVRQQSSMMRKCLETPGKLMDALKCGSTLVSELRTPSLGPKQYYELYMAVFDALRHLSVYLKENHPVNHLADLYELVQYAGNIVPRLYLMITVGTVYMSVEDAPVKEIMKDMMEMSRGVQHPIRGLFLRYYLSGQARDYLPTGTGNGPEGNIQDSINFVLTNFVEMNKLWVRLQHQGPSREREKRMQERRELELLVGSNVVRLSQLVDLDTYKSGILQALLEQVVQCRDVLAQEYLLEVITKVFPDEFHLHTLDLLLSAIARLNPHVDLKKIVIGLMDRLSSYAAREAETSMNAETRKQKEEEAVTKLLENLKVSEASQEKPKEDATPTQENGVEQTPTESEEQTKPADEVTANGRDEDQKPTSPQDIKLYDIFYEQVVSLIKSRGLPIQDTMALLVSLVNLALNTYPERLEYVDQILQFATKETAEYTDHADLHAAPTQQNLLHLLIAPLRSYVSVFTALALPHYLPLLSSQSYPTRRSVAGEIARTLLKDRTLITTTENLDRVLQALRVLIKEGVQQGGYPGSQRRGESDETIEEQGWLARLVHLLQAPENDTQLKLLQATRKAYLDGNERIRYTFPAIVSSSIRLARKLKSREHYDDNWQSQSSALYRFMHQCVNNLYQRVNPGCADLALRLFVMCGEVADQTGFEEFSYEFFAQAFTIYEDSISDSRAQFQAVCIIAGALHGTRGFSKENYDTLITKAALHGSKLLKKPDQCRAVYLASHLWWVIENPHRGEEDPKNLYRDGKRVLECLQRALRVADACMDTAVSVELFVEILNRYVYYFDQQNETVTTKYLNGLIELIHSNLQTDQDEPNPALENPKRHFYRTLEYIRAREFEGVVTDPRS
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme that catalyzes the elongation of monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAQHPLVQRLLDVKFDTKRFVAIATHGPKNFPDAEGRKFFADHFDVTIQASILYMVVVFGTKWFMRNRQPFQLTIPLNIWNFILAAFSIAGAVKMTPEFFGTIANKGIVASYCKVFDFTKGENGYWVWLFMASKLFELVDTIFLVLRKRPLMFLHWYHHILTMIYAWYSHPLTPGFNRYGIYLNFVVHAFMYSYYFLRSMKIRVPGFIAQAITSLQIVQFIISCAVLAHLGYLMHFTNANCDFEPSVFKLAVFMDTTYLALFVNFFLQSYVLRGGKDKYKAVPKKKNN
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MYAAADVSLVGTFAKLADRTAVPGALPPRLNEDPSLYGHLTSGLDLTIGCEGYSDTRSLDSRFHSIFDYLCKTSQLSSSFKEVLVVYCSHFQCLRLDDREYPSQPFGHKFEQYLTLNDRGLPHDKYERLTNDGCSKAVFRTTFTSGNKAIKVFYAAEMDAIDEERNFVELKTTSMSHDRWVQIASLSNYLQSFFGKIPYIICGRKPSFGNNVIYQVDKIQTADIPNYSGVHWKKEVCFQQIFNVLNAVKSRLQQDNEAVVFNLTQGTIYLETERAENCTFTDQAFLNYLN
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MTFGKQIDPDLTRLLDKKLNVKLNGNRTVQGILRGFDTFMNIALKDTVEVVSPTEKYEIGMVLIRGNSIILMEPLESM
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MHQMNAKMHFRFVFALLIVSFNRDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDKGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTAIDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNIPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQQHPHQSLEDDAQPADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSLDTYSECSEVDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTNNCGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS
The following text describes a protein:
Function:
Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Sequence:
MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAENDLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSITVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSLLAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTKIPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTILVTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVLLMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVDDIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKIIRKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVHSVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHNGSITVHSRIDKGTTFSFYIPTKR
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains (By similarity).
Sequence:
MSETSFNLISEKCDILSILRDHPENRIYQRKIQELSKRFTSIRKTKGDGNCFYRALGYSYLESLLGKSREILKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDSSVSSLLKVFNDQSSSDRIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMAMECDHVQITALSQALNIALQVEYVDEMDTALNHHVFPEAAIPSVYLLYKTSHYNILYAAEKH
The following text describes a protein:
Function:
Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.
Sequence:
MDTNKGAGERTVGNGDTTRETLVENGKNKVHIECKYCSSRILNAGMCQFVQTEYTLPALERDDSAQDPKDNVENVTDFWCVEDIYTFENIGFSNTVGKAKYLACADCDRGPVGWHSLETKKSFVALSRVRHL
The following text describes a protein:
Function:
Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MRATQSLPFKSFWSRSLDELSRLTNIVVKSENIRGATGPREIHNFQTPESVADCKLLSDADVGGSSTAHLDWVPPPNAIPTVTAGDGSDRKPYTPIPGSYARFHGTISLELPTDRREISRTGYAGFRTLDRPPTIFGRGLWDIDPYAYLAMRVKTDARSYFVNVRTESVVPLDLHQHRLFVKKPGQWETVLIKWNDFVRTNHGKVIEPQTGMLRQKVLSIGFSTTDRKAGPYELCVERLWATNDFDEAGVVETDVAGAQLKNKHGEKVKVTWGALEQE
The following text describes a protein:
Function:
Binds specifically to GTP-Rho.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDTLIPNGCKSNGPVENGYFKKGCNPFAQTGRSKLQNKRAVLNQKIIKQMRMRAGAENLLKATSNNKVREQVVLELSYVNSDLQLLMEQLEGLNSSVEVYQNVQESSSIPLIPLGLKETKDVDFSVPLKDFILEHYSEDGSNFQNQIDDLMDLRQACRTPSRNNSGVDLIANYFSQLSFLETRFFSPTRQIGIFFTWYDSFTGMPVCQNNISLEKASMLFNMAALYSQIGTRADRQTLAGLEDAIAAFQKSARVLHFLKETFTHTPSYDMSPAMLSMLLRLMLAQAHECLFEQITLPGIRNEFFCLLKMAQEAAKVAETYAQVHQSMIETPITKNVPFFWTTMSQLKINHYNSLAHYFVSTALLDHQLNPSDDEDKQEKALSQLYDAMPEGRSPLDILKNKDERRRIGKAHLQRSIMGHEEAIRTHCRCRHLQKLDILSDILRASLNRSLTKFEQNDKEDEFTDYMLAPDIISKTEKKAEMEIPAATKVKVTDLFQRLGPLSVFSAKQRWTAPRTIRLILQDRDLGFTLKGDAPVQIQSLDPLCPAAAGGLKEGDYLVAVGDTDCKWMGVSDVMKLLKDVDEEGINIRVVSMMDSSSQPMATKSATYCGGLSKTYSMICLAHDEDDKNPKSRKVAKKPSFLSFGLKNKKSSSTLSLPNADYSRPWNRPSANYSNSHHESGLY
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSKNDKNQKLTAYESYKKIESEIKFQTNLLEKSNPTIRCPIHQYNYSKTCRQCKKIVVEEVPTYQEKSINMDKYHYDVGDRGDNIIPIRGENAISNMNSLVRQNILTCPYYKELLQIRDINDIVTETDKIVTSVGTWAGPGVPSSFFCILHKLMSMNLNVKQLQILCDWKLNPYVRCLGLLYLRYSLDPNFLWGWMKRYILDEQEFKPSKDEDITIGDFCERLLTDLNYYNTRLPRIPQQIDTIIQAKILLSQEKRQRRNINQRIMALLQPGVSVRAISQKDDEWHVGKIESVDGTYLIIQFEEVMERISLGEIEFIPKNDEQRLYIAQMITEGMQEGQIQLPQEVVQQKSPSRSKSKKKKRSSSSSSQSSSSRSKSRRKSHKKKKNKHKSQKEHKKKKDKKKDKQKEKEKQKQKKEKERQRSNSPELGQYETNKERQERLEREIRRKQMDKAVAHSKQDVAKIPASYKTSLAAALPTSTKPVRQNSPSAIKKKEQFIELGNSETNNPKFEKESKTDQNNPFLKELIKKYGDDDV
The following text describes a protein:
Function:
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSQLNTVHLEQIISYLQFADKMRKHILSEVKEEIADHVDSRVDDSETYTGSEICDALEDLPDLLDTMLDRELEHQRDVSVFLIQKIFEQYRQLDMEISLKVPMLENEKDIKSSHALCEDLTTKPAETLKSAPLPPKDAKRVGEKLKEMKSQSKSKDPKSILEENLRLKKQIQDEMNAFPQYKKLQEMIHEREIELNGLKACL
The following text describes a protein:
Function:
Has a broad substrate specificity. Hydrolyzes various p-nitrophenyl phosphates, aromatic esters and p-nitrophenyl fatty acids in vitro. Most active against paraoxon, phenyl acetate and p-nitrophenyl caproate (C6), respectively. Also has tributyrinase activity, but shows no hydrolytic activity toward other triacylglycerols including tricaprylin, trimyristin, tripalmitin or triolein in vitro.
Sequence:
MPLDPEVRNFLQVYYKANIIDFTKYQFQEIRQKVNELLAKAVPKDPVGETRDMKIKLEDYELPIRIYSPIKRTNNGLVMHFHGGAWILGSIETEDAISRILSNSCECTVISVDYRLAPEYKFPTAVYDCFNAIVWARDNAGELGIDKDKIATFGISAGGNLVAATSLLARDNKLKLTAQVPVVPFVYLDLASKSMNRYRKGYFLDINLPVDYGVKMYIRDEKDLYNPLFSPLIAEDLSNLPQAIVVTAEYDPLRDQGEAYAYRLMESGVPTLSFRVNGNVHAFLGSPRTSRQVTVMIGALLKDIFK
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTRQLSIRSVKGNIYKIDVPEDATVGQAKEIFREQCDPEAKDITFIFKANRLDNSKLISSLDIKKTDFFIVHIVKKPAAPKPAEPAPAAVAPAPAPAPQTPAPAVPRAAPLPELVQPTQQNQFDMDALVSSPQFVTAVNSLEELGFKEEEATAALKAAKGNAELAYNFLEQGYIPSEQDIENQQNLINQLREKLTAEPSLIPQYILAIAAQHPDRAQQYMANPEQFLNDYGLDPNKFDIPQIKEQLNAASQEIENLAASGDFADAPDSFPQQEMNPMQARLSSYSPEEQEVLKRIFEIFPNQDQFTVIQVYEACGKDENQTVNCLLSMM