lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the fusion of nuclear envelopes during mating, ensuring proper karyogamy. Plays a role in the initiation of outer nuclear envelope fusion.
Subcellular Localization:
Nucleus outer membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MTAMKEDNAALITLKKNNDQEKLRVHKLTDASSNSADGFVINKAKNGGPLNKKSLVNNEQHIKKAVSPGRVRKHKTTTSSTKSRTKSKKKDASESKVQRENKGSFYQGAIFGSFLGAAVTTVLSNLAVKALQN
The following text describes a protein:
Function:
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
Sequence:
MSIWSSSYRKASDHGISSWGWNLSGQHSTYHALFPRAWTVYDGEPDPELKVSCRQISPFIPHDYRESSLPTSVFVYTLVNTGKERAQVSLLLTWANSIGGVSHLSGDHANEPFIGEDGVSGVLLHHKTKENPPVTFAVAACETQNVSVTVLPCFGMSEGSCVTAKDMWGKMVEDGHFDRENFSKGPSMPSSPGETHCAAVSATAWVEPHGKCTVAFAVAWSSPQVKFMKGKSYYRRYTRFYGTSERAAVDLVHHSLTNYKLWEEEIEKWQNPILNDVRLPEWYKFTLFNELYFLVAGGTLWIDSGVPSSDSVSTRITRPSNEVKVTKVKSNYKNGVQVEQTAYNGYGEGNHFSSSDKISESIITGSDDVGRFLYLEGVEYIMWCTYDVHFYASFALLALFPKIELSIQREFAKAVLCEDGRKVKFLAEGNWGIRKARGAIPHDLGMHDPWHEMNAYNIHDTSKWKDLNPKFVLQVYRDFAATGDFSFATDVWPSVCAAIEYMDQFDRDNDGLIENDGFPDQTYDTWTVHGISAYCGGLWLAALQAAAAMAMHVGDYAFAEKCKGRLIKAKTVFEAKLWNGSYFNYDSGSSSNSKSIQADQLAGQWYMASSGLPDLFDGVKIKSTLQKIYDFNVMKVRGGRMGAVNGMHPNGKVDETCMQSREIWTGVTYGLAATMLHAGMEEQAFTTAEGIFIAGWSEDGFGYSFQTPEGWTMDGHFRSLIYMRPLSIWGMQWALSMPKTILDAPKINIMDRIQVSPYTPQETGVRKIVEKAKCSIFRCSC
The following text describes a protein:
Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Subcellular Localization:
Membrane.
Sequence:
MKKGFYFLFFCFIYQNFSYGCKQFSRQNVTFQSVNFEFILQWDREDLREDVVFSVQYKRYGDKEWSIKHECQNISRTFCNLTNEIAGDVHELFEHEYYGRVRASSKYCHSDWVMSERVYPREHTHIGQPAVQYVKDVNSITIFVYTPYVPVKNKGGEPQSVQDLYHDMLFKYHVSLSIQEKHSMWQKSQADNKFEVTGLKPNTKYNGSVYILVENIRKSDIHTFVVQTLPDHSLFTLIVCGFAVSVLFLIIVLMYLSYRYVSLKGTKTPKSLVLSNIPAAHPMKPLKDYHLCSVSYAVSDTKELPADKNEPNDLQKPGEIAYKTQSQTTIRNFDSTFPKSSNCLQQSVDYGMVEERTVNKTSYLANPQTNLGKLGKPSLFPSNCSNQMDQSILLTAISNVDDGNQKMTERLRETTESFRSPKMFCFDEANSLRNQNENSLIHTVIVQDLLDLEEPKEQVEDLSILLSQDSTNHNEVTEVTEPAILPSVNTSYVFQCPLKNTQTDLQQRALSNIPAAHPMKPLKDYHLCSVLYAVSDTKEFPADKNEPNDLQKPGEIAYKTQSQTTIRNFDSTFPKSSNCLQQSVDYGMVEERTVNKTSYLANPQTNLGKLGKPSLFPSNCSNQMDQSFLLTAISNVDDGNQKMTERLRETTESFRSPKMFCFDEAKSLRNQNENSLIHTVIVQDLLDLEEPKEQVEDLSILLSQDSTNHNEVTEVTEPAILPSVNTSYVFQCPLKNTQTDLQQRVMVCQQPYRMQHCHVSKV
The following text describes a protein:
Function:
Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis.
Subcellular Localization:
Cytoplasm. Cytoplasmic granule. Note=In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules. In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1.
Sequence:
MTDLLRSVVTVIDVFYKYTKQDGECGTLSKGELKELLEKELHPVLKNPDDPDTVDVIMHMLDRDHDRRLDFTEFLLMIFKLTMACNKVLSKEYCKASGSKKHRRGHRHQEEESETEEDEEDTPGHKSGYRHSSWSEGEEHGYSSGHSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKRYHRSSCGHSWSGGKDRHGSSSVELRERINKSHISPSRESGEEYESGSGSNSWERKGHGGLSCGLETSGHESNSTQSRIREQKLGSSCSGSGDSGRRSHACGYSNSSGCGRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGARENGQPQNCGGQWRTGSSQSSCCGQYGSGGSQSCSNGQHEYGSCGRFSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQSSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGKTSGFGQHGSGSGQSSGFGQCGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQSSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQHGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQTTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQGTTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQQRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGSSQVWKHGSYGPAEYDYGHTGYGPSGGSRKSISNSHLSWSTDSTANKQLSRH
The following text describes a protein:
Function:
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
Sequence:
MSTHYIAGQWLAGQGETLESLDPVGQGVVWSGRGADATQVDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESATEVTSMVNKVAISVQAFRERTGEKSGPLADATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHRGLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRFDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGAQPLLAMTQPIDGAALLTPGILDVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTGAASSAPFGGIGASGNHRPSAYYAADYCAYPVASLESPSVSLPATLTPGISL
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
Subcellular Localization:
Plastid, chloroplast inner membrane.
Sequence:
MSSMNFNPFQNWFEKPPNPVPSINFVSLADSFFPKSQSPNFASIGLPKFSKKSPKPETAGTDEPGPYKQIAEQFLWECENIPDYRHTPEVDKLLNEDPVFEKKENPSTEEIEAEQKWWESFRASPVVQFMTRAEEIADDMNKMELEDNDTPYRKEDKDYWRAIPHVPGFDGRPMPRKAIKSKEESDDKFWDFMKQFLFGLWGFRQRPYPPGRPIDVAQAIGYKRLEKRYYDFIMKTGGWWYKDRLGRSRGPCEIITLKTAYGAGIIDRDTFIWGEDMDEWAPIHMVYGLEPAIATWEVRLGAAATAFLHKLQKGIPPWVPLKGREPKTYKQLQKEAIESKKRDMAVLEANGGVWPGVRTPSHALFLWASGSELTTVLESDHMPNKFIPKQLRLELAKVIPGLRPWEVISIEQAMDQISYGGEWYREPLGTYTTGPPYIREWNRSVMRLFRIFYNLSVRVGQKLERTVPGFDTIMDKVQKDYDKRIARRMKRREEELREEDLKHYSGRTDEDEEEEEEEDDDSNSKKD
The following text describes a protein:
Function:
Implicated in tumor angiogenesis (By similarity). May inhibits BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation. May play a role during myoblast and osteoblast differentiation, and maturation.
Subcellular Localization:
Secreted.
Sequence:
MVPGVRIIPSLLGLVMFWLPLDSQARSRSGKVCLFGEKIYTPGQSWHPYLEPQGTIYCVRCTCSENGHVNCYRLRCPPLHCSQPVMEPQQCCPRCVDPHVPSGLRVPLKSCQLNETTYQHGEIFSAQELFPARLSNQCVLCSCIEGHTYCGLMTCPEPSCPTTLPLPDSCCQTCKDRTTESSTEENLTQLQHGERHSQDPCSERRGPSTPAPTSLSSPLGFIPRHFQSVGMGSTTIKIILKEKHKKACTHNGKTYSHGEVWHPTVLSFGPMPCILCTCIDGYQDCHRVTCPTQYPCSQPKKVAGKCCKICPEDEAEDDHSEVISTRCPKVPGQFHVYTLASPSPDSLHRFVLEHEASDQVEMYIWKLVKGIYHLVQIKRVRKQDFQKEAQNFRLLTGTHEGYWTVFLAQTPELKVTASPDKVTKTL
The following text describes a protein:
Function:
The dimeric enzyme acts as an E1 ligase for sumo. It mediates ATP-dependent activation of sumo and formation of a thioester with a conserved cysteine residue on sae2 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSERYSHIIQALGQSTFDKIQTCKILVVGAGGIGCELLKNLVLTGFKNIDIIDLDTIDISNLNRQFLFRKQHIGMSKAKIAKESVMKYNEQVNITAHHGDVKSSEFGSEFFKQFDLVMNALDNISARRHVNRLCLSVDVPMIESGTAGYLGQVSVIRKGKTECFECQPIAVPKQFAVCTIRTNPSAPIHCIVWAKMLFGKLFGPKDDDGGGDSSSLTDLDNNIIHGTEELGNIKRDEQLLIEKEKGFKRWVFHKIFHTDIETLIHMPDLWKDKQPPTSLKLDEILSSKEVSQAEEEGDQLIFKLPDQKQWTFKENVEVFLDCLEKLKQQFDQSNSKPMTWDKDDELALSFVCSASNIRSKIFGIPMKSRFDVKSMAGNIIPAIATTNAVIGGLIVMEAIKVVDGRFDQCLSTYLYQLPSGKRLLMPTQLEPQNPKCFVCNRSFIICRLNTEKTTISQFIDHVLKKSLAVNEPILTVGNDIIYEGGDQDLSKEEIEQRSKIEKKTLATHRLTNDTSLVVEDYNQDFQITITIQHTTDFDEDTKKLKKQQQKEKDQKEGKTTTIEKEEDDKFFEIIGKTSQTTTTTTTTTTTTESDNNSNNNKNNNNNNDVEEDDGFMFIEDQPSSTTTSSATPSISKKRKEIDTNESEDLDSSKKLKSNLQD
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Miscellaneous:
MISCELLANEOUS: Present with 2340 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTVSNIGGEERLIILPDDYETSKTINTFTLPPPSNITSKPRIELFENINGKLYEIRSFQFGKGPSYSHEEDLANDKYHYTKENHPIKSTFIVNTSDPTDGYVFNSSKIHFCSLYDIAFSLIGFYYRNSVSADEQDYSNSSDTGENQKSNSKTNEKFLTVRDYHDFLTDNHDKNWENISLSRLKSGLAKVSETIEEAGDVYYKITSAMITQFLLGKVSKIVENFPPSIPTLKNAPTEIKQCYKVVMATNLLVSLIPRAAYHNLLTFSPTMDSGCLNPDIKASFIELENYETTNELQNAERELLMKSAMNVGLNSNGRVSLPVKKVTKKIVQNKKPKVAIGKGAIDGFFKRK
The following text describes a protein:
Function:
NADPH-dependent monooxygenase that detoxifies senecionine and similar plant alkaloids that are ingested by the larvae. Is active towards a narrow range of related substrates with highest activity towards senecionine, followed by seneciphylline, retrorsine, monocrotaline, senecivernine, axillarine and axillaridine.
Miscellaneous:
MISCELLANEOUS: Larvae store pyrrolizidine alkaloids from their host plant S.jacobaeae as non-toxic N-oxides. This serves as protection against insectivores; after ingestion of the larvae, the N-oxides are reduced in the gut of the insectivores to form toxic alkaloids.
Subcellular Localization:
Secreted.
Sequence:
MFRKFVIMLVLSLLVAAGISQASSASRVCIIGAGYSGLATARYLQDYGLNYTIFEATPNIGGTWRYDPRVGTDEDGIPIYSSNYKNLRVNSPVDLMTYHGYEFQEGTRSFISGNCFYKYMKSFVRHFGLMENIQVRSLVTWVQRTEDKWNLTYMKTDTRKNYTEECDFVVVASGEFSTPKIPHIKGQEEYKGKTMHSHDYKEAESFRGQRVLVIGAGPSGLDVVMQLSNITSKLVHSQHILKSWHIFNQPDFPGNFISKPNVKHFTANGAVFEDDTVEEFDMVIYCTGFYYNHPFLSTLSSGITATENYVMPLYQQVVNINQPTMTFVGICKPFFAKLLDQQAHYSAKLAAGHFKLPSQDKMLRHWLEHVQMLREAQFKITDVNSVGPNVDEYFKALHKEAGVPLLPPVYASVFVFSGKTLLEDLQNYREYDYRIISDTQFKKKYNPREEVCPYDD
The following text describes a protein:
Function:
Catalyzes the conversion of uridine into uridine monophosphate and cytidine into cytidine monophosphate in the pyrimidine salvage pathway.
Sequence:
MENRYISRIETISSHLLSTNDVSSQNESESITFVKPLPKNKKDHDQSIESDSSFTREKQFEEELDILGEINSKTGLFEIKQVPYQLSFDQGFFHACRAIEILTEKDPKRIICLGIAGPVGAGKTTLANKIGSLVNGVIISLQDFVKLENVKDNNYDDPVLIDFDKVISTLNELKENKTVIIPKIVNRKMESRSISLSTSKVIILEGAYALSARIRPLLDISVAITGGVHLDLIKSIMRGIVTSGKNSSKDVLAQITNVVFPMFKAFVEPDLDQAKIKIHSSFNPMSQVVEPVYVCKAKYDNNKQFFDQFLSSLNVVPVKKNFSDMYLYPPKYGVDGISQADKRNWIRIRRSEHGQFNITFYNEMMDGAVNTRPSLNFEISVKTLGGLLSLGYQIGAILNRTVEVWYDKNGVVITKEYIKELEKHFIQIKGHSRREVLDSAEKLKITGNHVPQTFLYLYFKKLKKSKNPNYSKLKPNNTNSKILKNNKDKKNL
The following text describes a protein:
Function:
Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Subcellular Localization:
Apical cell membrane. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, microvillus. Cell projection, ruffle. Membrane raft. Membrane; Single-pass type I membrane protein.
Sequence:
MRSAPLPPPLLVVLLLLLGGLGNIKTSSSAVELPSSQTSTTLNPTQLSGSSGTENPKVDLPGASSPEKSSTGPTGASSPEKSSTGPTGASLPEKSSTGPTGASLPEKSSTGSPGASLPEKSSTGSPGASLPEKSSTGSPGATSSKPDSHSSSVPTKADQEVDSTTLVAGGSKTQTTGVPIKDTSSALDPLNKPTLASSTSSDTGTLRTKTSTFSAQVVKSSPSSSATTKETITSREIDASTLLTNHQSPLSVTTTSQISGSSLPVTSLDTSSRAQGAFPTITSPGITLTSRTQSTVVTTGGQAPVPSDGSGPVTSQGPATLTSMVSALVTPSVIPKGSTSVFSDDSTSSTISYSSHHQPPDMATSESETFESIPNKITCQPDSYVTENLLILKMTNFTMCDSPKDSRNHPLYVALCRAGKVNFNKDRDVCHVQLVPQPEKQEVAILNVSVQTHLQPKELFEVLKKRWDDLKALGVSNMTYGKESLDKDEEDRFSLPLIITIVCMAAFLLLVAALYGCFHQRFSQRKDQQRLTEELQTVENGYHDNPTLEVMETSSEMQEKKVANLNGELGDSWIVPLDNLTKDDLDQEEEDTHL
The following text describes a protein:
Function:
Displays phosphatase activity against p-nitrophenyl phosphate (pNPP) in vitro; however, the physiological substrate is unknown.
Sequence:
MPIPGTPSRAELAEHLVRTRIAGDVATPRENNLSHYRKLANGDRGFWLGLELGDRWSDEQDVLAVMAERVGVNDDPEHRYGQDTIDPELTISALERMAGRLRKAADGGQRVLFATGHPGGLLDVHRATAAALRDAGCEIVVIPEGLTTEEGYVQQFADVSVLEHGASLWHTHSGEPMKAILTGLEREGRPLPDLVVADHGWAGYAAQHGVDSVGYADCNDPALFLAESEGTLQVAVPLDDHVVSPRYYDPMTAYLLTEAGLK
The following text describes a protein:
Function:
Adiponectin receptor. In insulin-producing cells, regulates insulin secretion and controls glucose and lipid metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDSATNLLEQQGSAADVSGGSHPAEVEVTTQARATFGMDAEGHATGEAVTTTTATLRREGSDEDIFEQVQMILRKRRGWGPEDSLSPNDLDILEYDDELVEEDDAGCPLPSTPEDTQLIEAEMTEVLKAGVLSDEIDLGALAHNAAEQAEEFVRKVWEASWKVCHYKNLPKWLQDNDFLHRGHRPPLPSFRACFKSIFRVHTETGNIWTHLLGCIAFIGVALYFISRPSVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCHSVEMGRLFSKLDYCGIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGVIPAIHYSIMEGWFSQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAFVHYHGISEMAMYRVMYSECTVPIEPITF
The following text describes a protein:
Function:
Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs.
Subcellular Localization:
Mitochondrion matrix. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly.
Sequence:
MGSSGLARLQGLFAVYKPPGLKWLHVRETVELQLLKGLNAQQPSAPEQHVRFLLGPVEGSEEKKLTLTATSVPSLTTHRLVRGPAFRNLKIGVGHRLDVQASGVLVLAVGHGRSLLTDMYDAHLTKDYTVRGLLGKATDNFCEDGQLIEKTTYDHVTRERLDRILAMIQGSHQKALVMYSNLDLKSQEAYERAVQGVIRPMNKSPMLIAGIRCLHFAPPEFLLEVQCMHETQQQLRRLVHEIGLELKTTAVCMQVRRTRDGFFGLDDALLRTQWDLHSIQDAIQTAAPRVARELRKNLSLMSGHQQQLPSAGQPWASRVQAPL
The following text describes a protein:
Function:
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. Has NADPH-dependent ferrireductase activity on the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Present with 46600 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Single-pass membrane protein; Cytoplasmic side. Cell membrane; Single-pass membrane protein; Cytoplasmic side.
Sequence:
MPFGIDNTDFTVLAGLVLAVLLYVKRNSIKELLMSDDGDITAVSSGNRDIAQVVTENNKNYLVLYASQTGTAEDYAKKFSKELVAKFNLNVMCADVENYDFESLNDVPVIVSIFISTYGEGDFPDGAVNFEDFICNAEAGALSNLRYNMFGLGNSTYEFFNGAAKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQFQYTVLNEITDSMSLGEPSAHYLPSHQLNRNADGIQLGPFDLSQPYIAPIVKSRELFSSNDRNCIHSEFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPETIFDLKPLDPTVKVPFPTPTTIGAAIKHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLLSKDKDQFAVEITSKYFNIADALKYLSDGAKWDTVPMQFLVESVPQMTPRYYSISSSSLSEKQTVHVTSIVENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGPRKLFANYKLPVHVRRSNFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNNVSLGKHILFYGSRNTDDFLYQDEWPEYAKKLDGSFEMVVAHSRLPNTKKVYVQDKLKDYEDQVFEMINNGAFIYVCGDAKGMAKGVSTALVGILSRGKSITTDEATELIKMLKTSGRYQEDVW
The following text describes a protein:
Function:
Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability.
Subcellular Localization:
Cytoplasm. Note=In the spermatid, colocalizes with Cul1 at the actin-based individualization complex and the cystic bulge.
Sequence:
MSDTKSEIEGFIAIPTTSGEQQQQQPQQQQNEQQVVGTKDIKAPDQVGKKQRPRLIQEKSTQETNPLILEHATLEWVPQHMDKLLNQYQECRKMPAAEWLHLLTYLVALECGFVEEETFAQKRHLIQPVPSFSSFHAQNVRILSEQPARYEVCFNDTVYIMRLRTLLDKHAPEETSLVAALQCRLMAVSLGDQLMITLSPAPPSKEPGYSVSLSIGRYVLNIQAKNKPIYHRFRKLDELSYQLKQHLFQPMRSQQLMQMEMKLQPSLLGLPDELYFEIFRYLDKSQLNVVARVNRHLHFYSKEVERKRLKGGRS
The following text describes a protein:
Function:
Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.
Subcellular Localization:
Nucleus.
Sequence:
MSLFTALNSTPHDALLEAEEHSRELQVEESFRVFQSALFHLKAKRFDDAEAKFEQLFNIEVLKPDHWGLYRYSSPTLDLLRYLAYRNRGVFYYQYVREHAEELDKDDIVDYILKVVENLLQALQHSDGDAAVTGLLLQVFRGFKSKRLQRWILEYELTKQPEEMLLLGRGRALLPDTRGLVEEYRRVLRDVRSEPVTEFAARVLTLVKTDSLEVQPLPPVLDKIEQLKDEDDAMMKQLAEYEVNLEELSWECIAESFRSLVPKYKYTNFFSKAPDPYSEAGDPIECIKFVHNDKPIEQEVMEQLSVQNEREPFAATQAATEAPTLEKEGSENGGRTESKRDSELPSDSQRPAQRSSKRFKERSTETNEAELLRPHQDFAALFYSCTGILEVRLEIELSHLNPEAIPSTYPAYMPMLDFYECLNSWTSKHTEFLNQSETKGTSKNKGKGEDSFQLTSLLRSSMFTEENRPTISLTELPYKEVAEFISTVNSNRLHFHAVRLLLLQVLLTVRPDGSCLITDTFWSPILYDTIESFVLSLESNIYDLVYSQSEKYKGLGLSFCEVLMNSLGGIYTEIHAKKISGGKYGELEAQKNKLEKKIDRWVLLLDQLVFEGKLKFRYLWSKFCYLQCISDVTDDRIIHSLDYITHELRNSSMDIDISYANYEHTPRLNMETVQSQLSKIKMMRKFTMVNQMDVDRNDSSNEDQIEALSRVLVGTSLLDTPEDRSMSEFVNQAPFLLKIKLWRIVLHHYLAVKDQSNFQICYFKVLHVLYERLCSKEYSDQSQLQRQQTLLSTLSLMRSFTSLFIELLSGANEWVINDTSQASEYFKLLIDVFILLYPLTYFETLSQKSATTVSFFKKAAKSSVILKDMFVDISCLLVLYFTGACTQKEVVNGVEVATEFIHALHLLIGGFTFCDAANGNFLNLAEHFFCSVEGSSSFIPLKQILLCKYRLSLGGDANSFEDHGAKPQVLEMHNAVRLAKYLIRFEYQNKNPYLISTNRSNLKQVIENVIDVIGKIPYAENHILARNVYYFEQYLEAPVTAKIIQEALQGCISIELTKPRDNLQEIVDLGLYYISGVQLLNLYKVRKKTLQARPSELDSIIETLKADILYKTNRFETWFLLGKCYSYVVEDDLIWTSDRLVVASKKATTASIQRKAILCYLMALNLCQLSVDDPSLSEAQKMENAFIKREIYEVLALELLNAYFKPMEGLPFQRDIAPALVLTETGELVEPKNSPQPSISSANIYRATLLVFTNADEMYKDSQDALQNWLNPHYIANLRFKHEREDFITDGFDIIIRACNLAMKASTSNDNIIEPHYSLVIKCYKSVKHGWLRPEDALKHLLNDNSFLAQEANFYSHNPENSVQDFYRKIITLLRRLLALDKRKWHHRPTYRIARILFDDFNDVDGAIQEMGVLMALKSVNKNLVNIWKPEYERPGKHFVYTYQYVMFYLKLLSHKNDYISLGHAARKMRRFGSGMVNGSLATDKAVEMFINGARAALGINEKEHAELLLPTLNYQAFNRYSDELIASFNKENYSYEVLESLAISYQLKKGSSGIAFDGVCLSIYFKYLYLPWVEEHEAAEATQSMVKFVEINKNVNPTENETASPQPAAEPQKSTTKQVSSRKRVSKKDAFDKISQIVDKIT
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNEENISISNEDLAVLGFFFEFLQESENDNENYTALINTIVTIPHKGDTTCLNLTLQEFIPEPKDLALYYRYQGSLTTPPCSEIVTWTLFTKTIKLSRRQFQAIYTSLYYHGNMSMVENFRPVNKLGARHVFTSDSRALVSILCGYV
The following text describes a protein:
Function:
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSTKRSPFLYPGAISSPDQLAILHLKRDLQTPTILKSTDEKDEGYAEGKVTNTRFGSFPHTTLIGIPWGTQVLASKVDTGSRGRRGDKKRKRDDVETADTPKAAELIAENAEDGSSTPTSATKEVTEAVAAGSGFIHFLPPTPENWTNSLPHRTQVVYTPDYSYILHRIRARPGTSLIEAGAGSGSFTHASTRAVFSGYPDEHTTKKRKLGKVWSFEFHEPRHAKLVEELEEHGLDKLVEITHRDVCEGGFLVDGKSPKAESIFLDLPAPWLAIPHLTRSPPPPIKNPNGELAPSRPISEPFVSALNPEAPVHLCTFSPCIEQVQRTISVMRQLGWVDIEMVELSAKRFEIRRERIGIDNGVQRGLQTTPANVEEAVARLLEVETGHQSFHKKGDAPDKMPRQNPNTRATLIKSLVEGKIYKEGKLVHKTEPEVRTHTSYLVFAVLPREWSEEDEKKAREKWEVNFNGEPEANAQKQSELPMSKRQMKKAARASHIKPATAAAPLAGDGTAVADGANGFIKEDTETKAEA
The following text describes a protein:
Function:
APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Subcellular Localization:
Secreted.
Sequence:
MGMMLLLLSMLAGLVAEAEGQAFHFGKCPNPPVQENFDLNKYLGRWYEIEKIPVSFEKGNCIQANYSLKENGRVKVLNQELRPDGTVNQIEGEATHSNITEPAKLGVKFFQLMPSAPYWVLATDYDNYALVYSCTNIIWLFHVDHIWILGRNRYLPQETVTYLKDILTSNNIDIEKMTLTDQANCPDFL
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Produced by alternative initiation at Met-1 of isoform 5; MISCELLANEOUS: [Isoform 5]: Major isoform.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQQALLRPRPGQATSHIFYEPDAYDDLDQEDPDDDLDI
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MTLPANDANSQTHTSANKAPPMRFRRPKIADPLVRPKKRVIARPAATSAPSVGIAAKPTTRPVISNVTPATQADKAAPGAPQNDFSVNGFSGPLLSETYVDYPIVITKRSLRVGLKHHIARFASKKTIDPRDESQFTRPVRLQRRDPRAKTQELNQDKGQAQKLTPQSSLQLGDAEREELEARKAAREKERAENLAQIAPSMGSAPKRSNIPKQRTQQVSKTDMTPEEVARARIKYEEALPWHLEDFDNKNIWVGNYEAALSETHAVFIPENGRMRMIPVEKWYKFGAKNQFRALTIEEAERFMAKKIKDPRWFMEKQQEQAQRKELEQFARQRKVYAGKQGTPAGVDGLEADEMDFEEDRFADDEEHDDLFNEDEETKAAEKRIKQDQLKANVFDLKDEKDYEEEELREKREREARRILGKKVRKALKKREKNYDYSSGSDANPYSDDESSDDSEAERLREEERKAEEDKNKKDSAPSTRGNVTPSGRPKHTEPLKKGPGAASRKRLGSPNVSDASGTDTSRKKAKSKHSSQPTPQPTSRALSPTAPPGQVGKKRIRNVAGAGSVSDADGGAASGGEMSESGKIKKLKLNPPAATSQGGTPQGSRAGSPTPIGSKGLAASRASSPESLRGKISLEVPCLHRNLSAYRTNFCVQGKLASLHRYLRGL