lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MDPQAATGRGPGERSSQEAPSAEAGFATADLSGRETETELAVDRLASGAQSIPADIPAHAEGPSSEEEGFAVEKEADGELYAWELSEGPSCPPMEQAADLFNEDWDLELKADQGNPYDADDIQGSISQEIKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED
The following text describes a protein:
Function:
Ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
Subcellular Localization:
Secreted.
Sequence:
MRQMKRTAYIILLVCVLALWMDSVQAGSSFLSPSQRPQGKDKKPPRVGRRDSDGILDLFMRPPLQDEDIRHITFNTPFEIGITMTEELFQQYGEVMQKIMQDLLMDTPAKE
The following text describes a protein:
Function:
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
Subcellular Localization:
Chromosome.
Sequence:
MEEEPVVSGTANRRTKRTRVQTRVNEEQNVNEEREESSDDFEESRGRAKRSKAVAGTSAAAAAASRNAHLSLIDVVKGDRRLIPLVVKHWVEHYEKNPKAAIAGLLSMMFEACGVKYHIEEDFLDQTDVDDVVVALVNMAKRVFSSIIFMRFSYLICLGEVEDYQSSKKKDFNNFKDNLVYFWDTLVAECENGPLFDKVLFDKCMDYVIALSCTPPRVYRQVASLMGLQLVTSFIHVAKVLGAQRETTQRQLNAEKKKKVDGPRVESLNKRLSLTHEKITIIEEMMRKIFTGLFMHRYRDVEPDIRMACIQSLGVWILSYPSLFLQDLYLKYLGWTLNDKSHGVRKASVLALQNLYEVNDNVPSLGLFTERFYKRMIELADDVDISVAVCAIGLVKQLIRHQLVPEEELSSLYDLLIDDPPDIRRAIGALVYDNLIAQRLNSSQSSSGDNTDSSEVHLSRLLRILREFSKDEMLSMYVIDDIWEYMDAMKDWKCILSMLLEEEPSAELSDVDATNLIRLLAASIRKAVGEKIVPASDNRKQYYTKAQKEMFESCKRDITVAMMRNYPQLLRKFMSDKAKIPYLLEIIVHMNLELYSLKRQDQNFKSAVLLMKEAFFKHGEKEALRSCVKAVGFCATESRGELQDFALNKLKEIEDELIVKLKSAIKEVVDGDDEYSLLVNLKRLYELQLSRQISIESLYKDFAETLKNFRSIDDEVIGFLLLNMHLHVCWCLHSIINSGTVPEQSVSSLISKRSTLFKLLESFLTTESPEGLRANHLACRVCVILSEQWCLFRKATFASTELEVLGYSPDESILQKFWKLGEHQLHISDETEEDDSNREYIEETNRDAIIIAVAKLVAVEAVPKEYLAPEIVSRFAMHGTSVSEVIKHLLTVLRNKGADVACLFLEALKKAYQRYLVVLSSDDDNSARKTFQECEDLASELAKTFGKAAKNKHRSDVLNIVTGGIQYAFSDAPEHLSFLDGAVLHFISKLPPPDIMDILKDVEKRTENVNMDEDPSGWRPYHIFVDTVCEKYAKDEGLQDDKEGTAMRRRGRPPKRQNLQGKKLFNKHTSSEDEESISGSDQDADEEKQDDEEEVPLIQSIKSSSKLRSLKISKRAEAM
The following text describes a protein:
Function:
Methylates ribosomal protein L11.
Subcellular Localization:
Cytoplasm.
Sequence:
MPWIQIKLNATNDNAEAIGDMLMEETGAVSVTFLDAKDTPVFEPLPGETRLWGDTDVVALYEADMDTSLILQQIKASNMLAEGFAHKVEQVEDKDWEREWMDNFHPMQFGRRLWICPSWREVPDPQAVNVMLDPGLAFGTGTHPTTALCLEWLDNLDLSGKTVIDFGCGSGILAIAAIKLGAAKVIGIDIDPQALLASKDNAARNGVEDQIEVYLPKDQPEGLVADVVVANILAGPLRELSPIIKGLLKPGGQLAMSGILDTQAESVAEFYRDDLELDPIAEKSEWCRISGRKLG
The following text describes a protein:
Function:
Inositol phosphate kinase with a broad substrate specificity.
Sequence:
MAATVDVERPVDIGELDLRPCEHQAGGHFASEQGKAAGTFVDSSGKFYKAFQDDIRGGREAAVYELIFGDADESVRKEDMEQLRRFVPKYFGTLVSDGKKLLALEDTCKAYTKPCVLDCKMGMTTIYDWAEDKYKTKNAGKDTATTQASLGYRVTGFKVWQQAKAEYFFADRHYGKKLTDGTMAAALATFANNGAIGPDAVYGGPNGAVAQIRALQSWFESQRSLVFFAASILVIYEGAATRPEDANVTIRFIDFAHTFPSKGQADANVTPAVKSLADLMEQVATGQAS
The following text describes a protein:
Function:
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8. Recognizes adjacent tubulin dimers along the same protofilament.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associates with microtubules.
Domain:
Metalloprotease with an atypical HExxxH zinc-binding motif instead of HExxH, which interrupts the active site-containing helix without affecting the integrity of the catalytic site arrangement; The N-terminal disordered region enhances its anchoring on microtubules, while dampening processivity on the polymerized substrate.
Sequence:
MVLDSGTQVYEQAPPSPPASSPSQHHKLKPSNRNGPPLYPWPQSLAMPLALAVPSALQHQTMWQTFSKLHLEQRSHMKRSESTYSVNSTGRRGRGKAPLGRGCDPGGGTLRPAASLPHIAKIRKDVVSGSNKSPCMLVALRPTNMDQEREKFFQSHYAYNPQFEYQEPMPMSVLEKYQEASGQFMHQAVGIIKAVLEKFGTYENFEAATGGQLLTKCQIWSIVRRYMQKEGCVGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNSRQPWHSTEGRQQYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHQAAHMSFRQLFQDLEQYVQDEDVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGILRILRHRQTIDFQLLTSLGKVSYEDVEQLRPHGVLDKTRVPHFMKDLDRYRQQLEHIMTTNRLDEAELGRLLPD
The following text describes a protein:
Function:
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD.
Sequence:
MMDKRTSEIEFHLKNLLACDAYKLSHRLMYPQDTQNLYSMLTARGVYGDFKEFVWNHDFAKEILLNVFNGFVNSVIEVKKNKLLAAALTDKLVSVFNDHELANEFTQHICHLASFLEKNKKMPLVAKIHESDQSLPFRTPLITIEGVENIPNNFVWLVNYFETVLLENIWLFQTASTVAKRIKSLLEKYAKETADETSFINFQCHDFSMRGMSSLQSALYVARAHLQYFTGSDTILGGDNSRSILASEHSVMCADGSKHELKTFQRLLEKFKDKKLSLVIDSYDMWNVLDNIIPRLKNLILMRGATLYLRADSGNYQTLICNPNYKKQDKSTWAMIDYLDHHFSSTINKKGYKVLNKKIGIIYGDGITYQKIEWILNCLKNHGYCSSNIIFGVGSSTYQNLNRDTLGFVYKLTAIKRNNRWIGVKKTPITDLSKSSKGGRYKTKRLITVY
The following text describes a protein:
Function:
Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes; Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
Sequence:
MSSESSKKRKPKVIRSDGAPAEGKRTRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDAAVEIEDRRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSNMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKMLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDDSVLHLTFYYLMNLNIMTVKARVTTATELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLDLGHPYLWVQKLGGLHFPKEQPQHTVITDHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCHYLFPAKVVSRLVKWVTIAHEDYTELHFTKDIVEAGLAGDTNLYYMALVERGTAKLQAAVVLNPGYSSIPPIFQLCLNWKGEKTNNNDDNIRAMESEVNVCYKELCGPRPGHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRIKPFKYNHPQGFFSHR
The following text describes a protein:
Function:
Putative oxidoreductase.
Sequence:
MLLLYKILNLAGDYIVAFLTVILSVLVLGLTPIFTLVNLFRNKTFNSPKNIVITGASSGIGYSLALHYSQPGVTISLFGRNEANLLKCKKECEAKGAVAEIKIADVTDRKTMKKYLTDFDNRYPVDLLIANAGIIESQLPNDFDFEEKTHKLTETNVIGMLNTVLPLLSKFEERKGGQICITSSLAGYMDFFFPAYSASKSYITSYAFTLRKRMAEFGVGVSVIVPGFITTPMTDSFKRQDLLFCLNVDQAIKIIANGIKYNMAQISFPFPTFLLGILFSISPPNFRGALSYLVSFAIKDIYFFDHVEKKEDKKNN
The following text describes a protein:
Function:
Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
Miscellaneous:
MISCELLANEOUS: Present with 704 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDTVTVLNELRAQFLRVCPEKDQMKRIIKPYIPVDEFNTEQCLDSSIRELYMNSDGVSLLPELESPPVSKDFMENYASLGKMRIMRENEGQKGKANQNLIGAEKTERDEEETRNLQDKSAKNTLIVEENGTLRYNPLNSSASNSLLNDDDHTSGKHHKTSSKEDSYLNSSMEMQKKSSKRSSLPFVRIFKSRRDHSNTSGNKNVMNTTNTRAKSSTLHPPGARHNKKGSKFDMNFDFDENLEEEDDDDDDDEEGDDIHSQFFQLDDDFDAKGSGASPAHKGINGMSNNKNNTYTNNRNSISILDDRESSNGNIGSASRLKSHFPTSQKGKIFLTDNKNDGQKSDSLNANKGIHGDGSSASGNGSVSRDGLTETESNNISDMESYINEKDLDDLNFDTVTSNINKTVSDLGGHESTNDGTAVMNRDSKDSRSNSNEFNAQNRDRITPGSSYGKSLLGSEYSEERYSNNDSSTMESGEMSLDSDMQTNTIPSHSIPMSMQKYGIYHGDDDSTLNNVFDKAVLTMNSSRHPKERRDTVISGKEPTSLTSSNRKFSVSSNLTSTRSPLLRGHGRTSSTASSEHMKAPKVSDSVLHRARKSTLTLKQDHSQPSVPSSVHKSSKEGNILIEKTTDYLVSKPKASQLSNMFNKKKKRTNTNSVDVLEYFSFVCGDKVPNYESMGLEIYIQASKKYKRNSFTTKVRKSSTIFEVIGFALFLYSTEKKPDNFEEDGLTVEDISNPNNFSLKIVDEDGEPFEDNFGKLDRKSTIQSISDSEVVLCKVDDAEKSQNEIETPLPFETGGGLMDASTLDANSSHDTTDGTINQLSFYKPIIGNEDDIDKTNGSKIIDVTVYLYPNVNPKFNYTTISVLVTSHINDILVKYCKMKNMDPNEYALKVLGKNYILDLNDTVLRLDGINKVELISKKDARELHLEKMKPDLKKPVLPTIQSNDLTPLTLEPLNSYLKADAGGAVAAIPENTKVTSKAKKISTKYKLGLAKQHSSSSVASGSVSTAGGLANGNGFFKNKNSSKSSLHGTLQFHNINRSQSTMEHTPDTPNGVGDNFQDLFTGAYHKYKVWRRQQMSFINKHERTLAIDGDYIYIVPPEGRIHWHDNVKTKSLHISQVVLVKKSKRVPEHFKIFVRREGQDDIKRYYFEAVSGQECTEIVTRLQNLLSAYRMNHK
The following text describes a protein:
Function:
Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MFGFLGAVTALVLGLGALIVRVLRAPIGRVLISGTILARVQEARQNHDDESVKKAVNEYDEALESTWYVEDMKAEELMRKIEKEEEQVAYDDPEKKIYHLCIVNLVIGTLYCAKGNYEFGISRIMKSLEPYNKKALMDVDEVYTLEEITAEPLPEAEAKEVKQKKKKKKKNKKGPESLNECRKEESELLKAVAPPEKNVASTDVSKVQEEESEMESTVKDSHLYQRTSIDELFMEYRDPRLLRRTDKACEIGTAMSSIRVQSERKPVVELPTDPRIQKGIPSNVKPLVGDNKQASDCHLKDKINLIGKQIPADPRIRPRPDSQGKVDSVKPFVEETVHAGITQLQEDRRQMQKQPLAVDPRTRPSLESQEQEDSNVEPVSEKVQVDIRRQMQKQPLAVDPRLQPRPQSQEQ
The following text describes a protein:
Function:
Binds the chemical odorant 2-isobutyl-3-methoxypyrazine.
Subcellular Localization:
Secreted.
Sequence:
MAKFLLLALTFGLAHAAMEGPWKTVAIAADRVDKIERGGELRIYCRSLTCEKECKEMKVTFYVNENGQCSLTTITGYLQEDGKTYKTQFQGNNRYKLVDESPENLTFYSENVDRADRKTKLLFILGHGPLTSEQKEKFAELAEEKGIPAGNIREVLITDYCPE
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site.
Subcellular Localization:
Nucleus speckle.
Sequence:
PPQPAHKMARDRKKRRSHSRSSSSSPERSSRRRRNNRSRSRDRRRRSIERHRRSRSRDRRRSRSRDRHRRSRSRGGRRSHSRSRSRDRRSRSRERRSRSKDRDRKPEKSAEDKRIEEQVAAAKAAAELACGALENDNSMDKDTRQQQLDLEMQRRRERIEKWREARKKTEEAAMIVLPTPGKKWSLEDDDEDEKEVAAAIEVKEEDDVDPLDAYMIDIHKEVKQLKDKAFKGNSKSEQKANKVTVIVGVAKKKEDKKKGELMEQNVDALEYSSEEEGEDLQSAMQGLQNNKAKKPATVSIEDISYAPFRKNFYIEVPELAKMTPGEVELWRAEMEGIKVRGKGCPKPIRNWAQCGVSKKVMEVLKKHGFEKPTPIQAQAIPAVMSGRDLIGIAKTGSGKTLAFLLPMFRHILDQPPLEDDDGPIAVIMTPTRELAMQITKDCKKFTKSLSLRVVCVYGGTGISEQIADLKRGAEIIVCTPGRMIDMLAANNGRVTNFRRTTYVVLDEADRMFDMGFEPQVMRIVDSVRPDRQTVMFSATFPRQMEALARRILMKPIEILVGGRSVVCKEVEQHIVIINDEDKFFKLLELLGLYQDKGSAIVFVDKQEHADVLLKDLMKASHNAMALHGGIDQFDRDSTIVDFKAGKVGVLIATSVAARGLDVKHLILVVNYDCPNHYEDYVHRCGRTGRAGNKGYAYTFITDDQGRYAADLSKALELSGNPVPEDLQRLFNNYKAKQEAEGKKVRGGSGFSGKGFKFDEAESHLKSEKKKFQRAALGMQDSDDEDAEADIDREIESMLAPKKRVIKELPIPLPMIALGSTAPVPAPAGGVSEKLEMARMLACRINMTRTFSAPSQPAPDIPQTPQSAAEAMMRGQFIPELPTPVVSARTIAEQRAEKLNTRLNYQPKIIEEEEVELPPQKERFQKFEEELEINDFPQQARWKVTSKEAMAQISEYSEAGITVRGTYYPPGKEAKGGERKLYLAIESTNELAVSKARAEIIRLIKEEMVKMQHSYQPINRGRYKVL
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MESTNIALPASTIFPVEVTAILKGAGDEIEKFAPILTFKYWHEVEDNIGEETNVFPKPPPTMVRKEFFSNFESPVKGQIDNWSIKVGDMIESADQIVAAVQEPCTHAVQYGGMCAWCGASVADEKDYTDFSNKDRAPISMSHSTAGLTVSLSEAQRLEEGSTKQLLKQRKLILVVDLDQTVIHVTVDPTVGEWKKDPSNPNYDAVKDVRVFSLEEMTMVSYDGGKPVPQLCYYYVKLRPHLKEFLEVVSEKYELHIYTMATRAYAKAIAEIIDPDGRYFGDRILSRDESGSLTQKSLQRLFPVDTSMVAIIDDRGDVWKWSKNLIRVVPYDFFVGIGDINSSFLPQRAGMVTPNKPPGKDERIEELDDKKEGNEQEDNPTTESNGTNEDKGKEIDNGESDEDSDKKEHDKKVETTEGSEADEKSDPETTEEATKPSSAPAEKASPVANMLSLDKALPAAEDERKCSLEAQQKDRPLAKLQSDLDSASSSEDESHEERHHLLVDNDNELIHVQKALLKLHEDYYKDYDDHVKHHEDILPDVQDILSSLTYPVFGGCVFLFSGIIPIGVNIQHADISMWVKKFGATVVEDVSKQVTHVIAASGNTRKVRQASRYKRIKFVYISWIFDCISQWKRVPVEGHEIPQQEINENGFSDGGEHVDDDDDDDDDDLEAAQPFSLSNMDWGDELGSSDDDEDEEEADHADDEGSNKRSHDEDDDTDSLTKRPKTVDENDGGGEGDDDFAAQLEADLLDM
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm, cytosol. Rough endoplasmic reticulum.
Sequence:
MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIRRMVSVSLGFAHHFGTSWTLPCALECVMVPE
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDNNLTSKLKYREAKLGYLMILPLLTVVLVFIILPVMGTFWISLHRDVTFIPEKPFVGLRNYLRVLSAREFWYSTFVTVSFSFVSVSLETILGLSFALILNERLKGRGVLRAIVLIPWAVPTIISARTWELMYNYSYGLFNWILSILGVSPVNWLGTPISAFFAIVIADVWKTTPFMTLLLLAGLQAIPQDLYEAALIDGASMFERFKSITLPLLKPVLIVALILRTIDALRVFDIIYVLTGGGPGGATTSISLLAFNYYNLGDYGIGSAISILTFVLVLSFTIVYLKVGRFRRD
The following text describes a protein:
Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Binds to microtubules.
Domain:
The DVD domain (residues 311-334) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation (By similarity); The D domain (residues 4-19) contains a conserved docking site and is required for the binding to MAPK substrates.
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSEEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKATDVASFVKSILGD
The following text describes a protein:
Function:
This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).
Sequence:
MAEIINRNKALAVSPLKASQTMGAALAILGLALSMPLFHGSQGCTAFAKVFFVRHFREPVPLQTTAMDQVSSVMGADENVVEALKTICERQNPSVIGLLTTGLSETQGCDLHTALHEFRTQYEEYKDVPIVPVNTPDFSGCFESGFAAAVKAIVETLVPERRDQVGKRPRQVNVLCSANLTPGDLEYIAESIESFGLRPLLIPDLSGSLDGHLDENRFNALTTGGLSVAELATAGQSVATLVVGQSLAGAADALAERTGVPDRRFGMLYGLDAVDAWLMALAEISGNPVPDRYKRQRAQLQDAMLDTHFMLSSARTAIAADPDLLLGFDALLRSMGAHTVAAVVPARAAALVDSPLPSVRVGDLEDLEHAARAGQAQLVIGNSHALASARRLGVPLLRAGFPQYDLLGGFQRCWSGYRGSSQVLFDLANLLVEHHQGIQPYHSIYAQKPATEQPQWRH
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MDLILLQKVTNLGNLGDKVSVKPGYGRNFLVPQGKAVPATAANVEAFETKRAEYEAKANTILADAQSRATKFEGASVTIGAHASTEGKLYGSVGPRDIAEAFTAAGLPLEKSEVILGEGAFRNVGEYDVVLHLHADVETTVKVIVESDA
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MPSQDNQPENNQVLAEQRDNDKDHLQMLEQQISRENKDIMDKEEAAKAKLEHFQKGSELFRKSLGLEFKKIDDDHLQFVFKYIDPNDWERPFTFTVRIDSNDRSYKGNANSRPVYNAALKRRE
The following text describes a protein:
Function:
Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Sequence:
MTPMSDGGTSESIFDLDYTSWKIRSTLAVAGFVFYLGVFVVCHQLSSSLNATYRSLVAREKVFWNLAATRAVFGVQSTAAGLWALLVDPVLHADKARGQQNWCWFHIATATGFFFFENVAVHLSNVLFRTFDLFLAIHHLFAFLGFLGSVVNLGAGHYLAMSTLLLEASTPFTCISWMLLKAGWSESLFWKLNQWLMIHMFHCRMVLTYHMWWVCFWHWDGLVSSLYLPHLALFLVGLGLLTLVINPYWTHKKTQQLLNPVDWNFAQPAPRSSRPAGANGQVPQKKGQ
The following text describes a protein:
Function:
Catalyzes the conversion of butyryl-CoA through butyryl phosphate to butyrate.
Sequence:
MSKNFDELLSRLKEVPTKKVAVAVAQDEPVLEAIKEATENNIAQAILVGDKQQIHEIAKKINLDLSDYEIMDIKDPKKATLEAVKLVSSGHADMLMKGLVDTATFLRSVLNKEVGLRTGKLMSHVAVFDVEGWDRLLFLTDAAFNTYPEFKDKVGMINNAVVVAHACGIDVPRVAPICPVEVVNTSMQSTVDAALLAKMSDRGQIKGCVIDGPFALDNAISEEAAHHKGVTGSVAGKADILLLPNIEAANVMYKTLTYFSKSRNGGLLVGTSAPVILTSRADSFETKVNSIALAALVAARNK
The following text describes a protein:
Function:
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGSQQEYVGSGKEKVGEVQALLFAKAQELAGVSQITLEIQKGWTTANCFEAVMTKYPALKAIRSCMMVALNHDYVTEPVAVKDGDELALIPPISGG
The following text describes a protein:
Function:
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Sequence:
MLDKHGRKINYLRVSVTDRCNLRCVYCMPPEGIVKKEHDNIMRYEEIFKVVKSASLLGVNKIRFTGGEPLILKDIDKLIYNTSKINSIKDIAMTTNAILLEDMVEELKKAGLKRVNISLDSLKEDRFKSITRGGDINKVFKSIEKSLSIGMKPIKINTVIMKGINDDEIDDFMNLTKKYPISVRFIELMPIGEGRKLYKDGYISSEEIISKHSDLIPVETEKSSTALLYKFKESKENIGFISPMSCKFCSGCNRVRLTSEGTLKPCLHSEKEVNLKNYVGNNQALLSKINETIYNKPLEHHMIEEKESKSKKMMYQIGG
The following text describes a protein:
Function:
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Tightly associated with the nucleus. It is present in a granular pattern that excludes the nucleolus.
Sequence:
MFASLDTPAVHQRKKYEFTPIGHIKEKENMIAQELRQNKRPPLEDEEDAAIEGNYMKRTRVGDDTMNSQQLFNETSFDDTLPEQTLQGISAIKKNLAPELLSNDNKEKAELASNPLKEQQHALQKLNMENYSLRVKCNSLLKFLNNVTDDGKLKQGLEMLDELQEWKTKHHELIQRFKELQLRYDELEQREPEPLKVAEPADHSHCEKLRAELETSLKETRSQLDEVQATVSTLEKRLVEVKKDYSEKEHQYKMSLDIAKSENNRLTSSLSSREDALNEAQEKINRLMVQLEEFDHTSGSLLELEKKIDDKNQGIRNLETRLQELNFHRQDLERQLLTANETIEALKKEHEEYREQNELKLTSLHKNTSGEDRLRKQLRDLAEDKEGLQKLRQTLEERNKELDERVEALESQVAAIEEDRQKIIGEQQQVVRNLKLEHQKRAQNLKREIEELRELNQQLEETNRSYKKRFEHFSRNSPARKATQEELTAKDREIGALKRTIRDIEESVLRTTRELETAKIQHRREKSMLEARLDQAASEEPFERSRLEKEISMLKLEIRSIQDTKERELSLWESKYESLKNTYEKLLQQDKHSNLNEILEDRREELKSLMKKYNDLTTENLELTRELNKQKSHKEAYKEDLRKVQARLDFITKEFVKLKESAPEPKDSSDELNSKWMEKYQNMKIKLLNELKVLQDENIQLERRLLDRSQQQSHNLAETPTQSRDSSLQDKVDYYRLKYHDEVRKNNDLRVINEYLNRVLKASSQHLKLDILKLENEISPLNSSTTYINDYDYSYAPSYYSRRGRPLKFKTVAIFVLSCIRMYQATLRRRWDQQRINYLQRKIAYGEDRITW
The following text describes a protein:
Function:
Probable substrate recognition component of tsome E3 ubiquitin-protein ligase complex (By similarity). Plays a key role in cell competition via its interaction with l(2)gl.
Subcellular Localization:
Nucleus.
Domain:
The DWD boxes are required for interaction with DDB1.
Sequence:
MSEGSGSENAAAAEAAAEAEAATEAALMAEAVAVAYQSDEEEQPEAEDMPEQAGDNQEEDAAEQQDGGEPEADEDADADDAMSVENAENESDSGGNAEETAAADRRQATKKELTQIIDKWEQQQTQNGYDPVPTLRSLAEIFEREKDVYRRKDPDPLDSRHPYRADPSCQYGLLLKLLFRKDTFMGKLLNDYLRENYFSRQNVSRSSLELNILACRLILEIMPGMETSAVFQTAEGDGTINRIYSWAEDSIEPLQSYATGLLAEAMEVSDIAINFRDLNIRLVPKMIKRLHMLLAISKSATSDVNTSMHNLSADSSTAGMLSWVACASNASAPQSPQHNGSGLGASSSQHGDASNMSILFENSRDAFSVSRYYKRMYIPLHPATADTSQMLIMRFLTSLGEYQEFLAMAFENNVMQLIFGYLENLDRRDTCLAYEVLKYLASLLCHKKFALEFISHGGLELLLKVPRPSLATTGVSIAIYYLAYCEDAMERICSMQRPLISELVRYALWILGRCHDSSKCHATMFFSLSFQFKVILDEFDAQDGLRKLYNVISVLKILDPSHNDSDNDSDFNEDVECASRQMVRHVCVALKRYMEAHFFYKYNSFLCQTNAASPAPSSAHYFNQNPTVAAKLTFDQLNDQIRTLQEHTSIRAHWQPVDQLMKLGGITMLLRIIAFSYDWVNSGRSETVRSALDVLSVCCIIPRVYVVLCERLLMLDKTTTSGFCSVLGAAAGEISSDAEVIKSALAVLCHCVCSPIIRKDSGTSLIKFGTSSRKNKANHKYAEELIERVWESVCSNNGIVVLLSLMQTKGPITDADCIRGMACRALAGLARSDRVRQIVSKLPLFASGQLQTLMRDPILQEKRAEHVIFQKYALELLERVSGKTKPLNNPLDPSLSNMHKANVIAQTRIQYNKQQLYQLIFEHLESNGLSQTAQMLQREVGLPLQTPTTRSFHQSPFDYKSLPSGSSSLSRNRLRSRMQDVNAAIMGNGDLNRSFGEDSSPAGAGGSNAGDGVSIPNFSSLNTTQTPIKIRRTDRSSVSRSIQKQAMEPGGMSVGLAEDGQLHPKRITLNTIVTEYLTNQHSLCNNPVTTCPQFDLYEPHKCPDPKPSRLLSSNYNLTSRHARTQAGFNTSRFDRRYVHTHFSPWRSIRSADYEDLEFTCCDLAGKYIIVGTQQGDGRVFNMNDGVEQFFSNCHNFSVDAIKANRAGDLVITSSFWRTPTSILWSIADDEFKLKLRLPDVTYCEFSQTVQDRLLGTQNECATLFDINTGSKVASFTPTIPNLYTKNRATLCRTDELILSDGVLWDVRSGKEIHKFDKFNQCISGVFHPNCLEIIANTEVWDLRTFHLLQTVPVLDQRNCTFSPMHVIYGASLGADRDHDMETTTYDTSFNVLDAYDYSSIATIDVKRNINDLSVSANGSLIAVVEDYSGYESKQETYVKIYAVGVKKSERSEEEDDEEVPESDEDGSDTGSENTFAIGQNLLGFPLLRNLHGSDNDDEDLDEDDDDGEPLDSDDDSDDDDGSDNGDDDGDFDVLEYFDRSSSDD