lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle membrane.
Sequence:
MDPRGGITQIELEYMVHDEDAEPIALPLPLLEKITNYFSHELIIGRGGFAVVYKVSRVLLLLQAVLDNGIVTVKRLFDTHMHEEQFQGEVECLMKVKHKNIVRFLGYCADTQGNISDYKGKMVMADVQQRLLCFEYLPKGSLDGYITDSPGELNWRKRYDIIKGICEGLNYPHQNNILHLDLTPGNILLDEDMMPKITDFGLSRCFEEDQTGVITKNVAGTRGYLAPECYNKEIVLAHKFDLYSLGVIMIEILTGKKGCQVTIENVLQIWNNTVLDALQWGQIRVCAKIGMECTEVDPAKRPASMKHIMDWLAEIECSTHVIPAGGTRELLLVHPSALCFPFEPNKAITCPLQLTNNTDKHVAFRLMDNSMESSFLRLPLYDVMPPNTPYTLIVTTQEKEDLPRKYIIDVILQSATLILGDDDHINTFRSQPDKFFQETGNDIQVVKRKALYTLTHIATSFSKPILSTVKVHVYIEMHLSCLDTNRAKQWIIIGDENGHVGFWDYPTQKKVDALKVSASRVTCIRFIERKQWIVAGTEDGYLHVYSYETRIQKITSLRVGAIENLESRAAHTHLAIHPTQPYLLSVYGFKVKLWDWDVGWECIQTFENEELMTILRVAFNPNDTFATASMDCTVEVWSLDSPEFIYTLVGHSSIVNCLDFFTCDDQEYLVTGSHDQTAKIWDLRKMMCIHTLEAFVSPVMSLLYQPDLQILITGSKDGAIYLWSTTNCGNYSCPPTLNRVIKIGCVGAVYHIACVMGGLVIGKENAVAIMDIDDVNYQEQPTDKSEQQLSACTTHHAGDMSKEKAGSISKLLDVHPLELRFPYCPNEPIPCSLHLTNNTDENVAFRLVDKSGKSPWCFAKLPLCGIVPHGSTYTLTVTMKEEMKLKEETDFDLVIQSSLLGDKYIEVFNDQSESDTFFKEAKQFGNMVHEVTLKAVYVQYGEITSENISVKYNPDSLWSLDAHPTEPWILTGHNSGYARIWNNEMKFLINSFKVSDQDAVSCVKFIARRQLIVAMTDRAHLHVYDCSCVTKIEKISFERGDYGTSTLLAVHPILPYVLASGLMLLNWDLSWKTTRIFESEAVTAEAVAFNTRDTNSFASGSYDGEVQVWRFDSSDPEYSLLGHLKKVTCLDFVTCGDQQYLISGSYDATVKIWDLQKRECICTLEAMSPVHCVLAHPNLPVIITGTEHGIIHLWNSTDFRLKRTISLGGGGPVITLGCLMGSPRVVIGQENAFFAMDIHDDWGGQPQGRDNFIGLLGSSLEEGLHAKRHRQW
The following text describes a protein:
Function:
Antibacterial activity against representative Gram-negative and Gram-positive bacteria and exhibits a very high hemolytic activity.
Subcellular Localization:
Secreted.
Sequence:
FITLLLRKFICSITKKC
The following text describes a protein:
Function:
Catalyzes the NAD-dependent oxidation of highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MEDLSDKGSESEVVNIKSPNGGVSSEESHTKTCADCGTSKTPLWRGGPAGPKSLCNACGIRSRKKRRAALGLNKEDKKPKKTSFCGSNKIGDNTKQRLMALGREVLMQRKKLGEEEQAAVLLMALSYGSLW
The following text describes a protein:
Function:
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.
Subcellular Localization:
Nucleus.
Sequence:
MLFTHGELNMENSSTENATYSQDQDETKSKKDEMELDIKTENTDVLIGPTDEPCTSEQRDDQISSIQPEQSSKENSEHQLVKEEDFTSDHAGLTGEDQSSGGQPALIRDALTSDQSGRADQSSNIKSEPIDEQICSVQSGPAEMQYGTVVSPQSGTGSLALLSMQYRGNSSDDNCSDSDSDSSSSTSSSSSSSSSSSSEPFEVVIMPNKAEDDDDDEGFAGGNKKSAPVKTQDELLIDDLPAVENLIISLPEDTEMEPIGTISSIVDQLVIVESYKNLPPLNEESVLFSKNRNSVGKVFEIFGPVCQPFYVLRFNSHDDIEQKDLKVRDPVYFAPKLKDFTDYIFTDKLKTLKGSDASWKNDQEPPPEALDFSDDEQERLAKQKLKEQKRRQQNDSDSEDESDAQKMPQKAARRKPRQNRNHPRGQYHNRGGGFHSNFHAHPRFPPEYMLPHPDPQMFPYQGPMVPHFPRPSPYHMGMAPWPPGPNQGFMFQPPPPPPPPPYQ
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MEDYSEVRVQLTRRFADFFEYDFVTPGQGSWSYARALEDLYEPVEGDGKAYRIKSRRLMVAEHHLRKFDEPLLLQLLQKPLECLPAFEDALTNFVKSGVDAVLQRLLEETGNDNLYIGLKGDFGRSEVSPRQLTSDLLNQLVCVFGIVTKCSLVRPKLVSSVHYSEATKEYTTNQYRDVTSMRGAPTQGTYPQYDTAGNPLTTEFGLCKYIDNQTLHIQELPETAPPGQLPHSTEIVLEADLVDSAKPGDRIAVVGIYKPLTSRQAGHISAVYKAVLVGISVQKLNKDSQTKVTMADAREIKRLASKPRVLDLLGASLAPSIFGHDIIKKGLALMLFGGLEKTLENGTHLRGDINALMVGDPGVAKSQLLRAVMNIAPHAVSTTGRGSSGVGLTAAVTSDGETGEKRLEAGAMVLADRGVVCIDEFDKMSDQDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVLAAANPLYGSYDRHISVTRNVNLPDSLLSRFDLLFVVLDSMNDERDRQVALHVLRQHQYRPPGDDGRGATNLHETIHDRRLSLDQDPEDLRMWLKIDTRLHGAAAEAEQQVLTTEFLRKYLIFAKRKYARAAQSAGGKGGSSVLTMEETAIKRIVDYYVSLRALPPTQRNFPVTPRCLETIIRLATAHCKVRLGDVISRQDVAVACALLDHVMRREIVGEDDHANKATKAARRNGGDDDDNGDEDGGDAPAHGRQEQDEEMADADGAAAAPATGAYGAEAPASARARRTKRARDADAAGPSGQEGNEPTGEVAARGRRPRAAPSGLTGDVATALAAAGVQVVPDGHEEAMAAQEASGSETYTTLESLTDAVKKAVNEQVAAILEQRGRDDLVELAELKRCVADQGFSISSDALGAYLTWMSANHDTEMAKGNYLPDIAYDVESKLFSFM
The following text describes a protein:
Function:
Vacuolar Fe(2+) uptake transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
LVELRQTPSKFAEIVGHPERFGFHVFITFVSYIVFGLVAPITYGFSFRESDDKGKKLIAMSAASVLCVILLAIAKAKVTSKSYIKTTLQYVAIGVAASGLSYVTGKYVRKLLEKLGWITDSNSPSSHYGVVGKGSSFSRMLGRKASRDAYLYY
The following text describes a protein:
Function:
Required for the processing of the 27S pre-rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLLAEPQQPVEDMDASTEDVSESFKAEFADSTDSEESFTDEYDSDEELRQAFLRNELKPGLNVILKEERQPINDTIKLKAALETCTLKAPWLERMDLVNDLAPLTPELAIQIEKHEQKRENLFKGNRKIPYVKPEADTVLNDFKREILFHRQAQAATLEGIGRLHELGIATKRPDDYFAEMAKTDEHMQRIRKVLLDKQEGIAKSERIRQLREQRRIGKLIQREATEKRDEERRKMLGDIKKFRKGKLANLDFLDDDDGPRGEFRKSGKGPGKGGKGGKGGKGGASAKRKARDAKFGFGGKKKGKKQNTKESCMNDGPRRRGGPGGAKGGGGGGAKTRPGKARRAQMKSKGGGGRKK
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGFSAEQAKKDGKDQSPVSESSSVGGTSPATASSVVSPNEPKLSGKEAKALKKARKQASRRAKAEAAAANNPPGVSEEKKVAIPNKNSNQQKKASKQNPQNSPETDANLQEKKIFEEKQVSIFSHLDWRRRRTTENIPKDIHPAVIRLGLKLANYKIFGSNQRCIDLLKTFKIVIQDYQTPYGTTLSRHLTTHINSQIAYLVSTRPLSISMGNAIRFLKLEISVLDIDLTDDEGKELLLEKIDSYIRDRIIIAGQVIVQAATEKIQDGDVILTYLHSSTVNDVLIHAKNVGKKFRVVVVDSRPEFEGRVCLKLLTEHGIECTYVMISALSYIMQEVTKIFLGGHAMLSNGALYSRAGTSLISLLGHESNVPVIACCESYKFTERIQLDSLVYNELAPGDQLVNMGVDDFEEKPGVLANWKSVKNLKLLSLKYDVTPPRLITVCVCEMGLLPSTSVPAIINEFKQVYA
The following text describes a protein:
Function:
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASPDAEDASPSPEYRSDLDDDMAAEQKTDDGSPSQKSSNGQKPASNAKDPLRPRRKKARRACFACQRAHLTCGDERPCTRCIKRGLQDHCMDGVRKKAKYLHDAPDGALMPGVGGHYPYMNGNRPTPLPSQDTHNVPMAPQGNMYTQAPSGTFYQPPSAQIPLPQAQHGRSFSDQQSPLSPPFSQAHHGPNVNPPSSISQGQPGQMQQFGPLFDPSDPALFNFDISSLNFGNHYGALEFGMLGHMSSAVDAPNDNTMMNAMNQTANMYGPQMAGAYGPNNPNAAMPFAQNSLPAGEWQESQSRQNSMHIHTPTSSATALDHGGHRHDSLNGPHAFAIGQGPSSHSTASPASTDASAFENDNPLSTATFFANTNRGQPQRSPTTNRHHQGNRPPSTALQPIHSNGVRKRHRDTKSIYQGIKKPFDYVKGYHRLFQICHKKFSKSLLAQAQQYLNLYRPVLLSVREEMDTDDLIHQEMGLQRNLMTLQDHFTEVGTPFLICRRSGEIVSCNKEFTILTGWRQDVLLGREPNLNVNLGNSREADESEMSTQTNTTPNLTGQEAETGTPAVNAIQLMDAKSALEYLQNFSELCWQDPHGHAKQRANMLRYQTKADFDRIQEMKANADHKSDAFVKMEGGAVHQGESAMQRLGAKNGMVDCMIWWHIKRDIFEMPVLVCMSVMPVLDKGLQ
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis. Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks. Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta. Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome. Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis. Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPQQQPPPPPQQQQQQQPPPPPPPPPPLPQERNNVGERDDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPILRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKIFVKTLKGTHFEIEVKPEDTVADVKKNIDTAQGPDIYPAAQQMLIHQGKVLKDNTTLDDNKVAENSFIVIMLTKNKVSSSGASTASTTSAPTSQLPDKVLNILEFLLMHAWLIILEKGFIKWGLNCVCHTYTCKSVNEFKSHKQSLCIAVAEACCGLGCPYAYVVCGLTSVNIVIHDKLMNKVSSSEASTTSATPAPTSQVESAAPAETQPSTTPEAPAPIVAVPESVPEPAVTQAAPASDSQMDVYSQAASNLVAGNNIEAIIQQILDMGGGSWDRDTVVRALRAAYNNPERAVEYLYSGIPAQAAVPAVARAPAAGQAANPPAQAQQPAAPTSGPNANPLDLFPQGLPNTGSNAGAGTLDFLRNSQQFQALRAMVQANPQILQPMLQELGKQNPHLMRLIQEHQADFLRLINEPVEGEGNLLGQLAAAMPQAVTVTPEEREAIERLEAMGFDRNIVLEVFFACNKNEELAANYLLDHMHEFEE
The following text describes a protein:
Function:
May modulate immune response and may play a role in inflammation. Down-modulates STAT3 signaling throught direct interaction with IL6ST, resulting in the inhibition of phosphorylation of STAT3 at Tyr-705 (By similarity). May negatively regulates AKT signaling by modulating the activity of mTORC2 complex through RICTOR interaction (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSRPIVLHICLAFCSLLLLNFAAQCLAFPNLERREIVLLHAEKGQSERLNTDDLENDSVTSNTPVSGDPMIVLAGPSTMSLNKVFPSNKETSPVGAGLMQADGSNIYTATEPEVPAGEEVFGSSQPERMSPESRPSKATLTNPVMPTASLNIDEREEPSRGTIIQPTVEGTTEATQGFLSYVDDQLFATESPEGLSLGHSPLSLVNTKEMLTTSPRTEKFEANPEHKTTSFPGSKLTAGTEPSQMTADNTQATAATKHWLPTSESILSVEPETDSLLGAPEVTTSVSTAVAAAPVISDEWDDTKLESVSQIKTPKLGDNTETQVRMEISQTTQAPDIGMEVMEEGKALTEAADVSLKLPEMETHMETTLPMAHGGERASDQSSVTPTSPMGDTKVSVMNLVQDTADFVESTKENGAMFLETTVSISEYESEVHQPLGNRFKDIITQEMTTAVQAAEATVSLVTQEQQVATLEVTRGEDETKGGRELPSATVDAPRATQLSRRWEPLATVVSTTPIPVSFKVTPAVEDVMDTVTGPNEELFTPILGSPVTPPGITEEAPSTSPALADPEASSERRTAAPSFSYVNTAASYGLDQLESEEGEDDEDEEDEEEEDEEEEDEEEDEEDKDADSLDEALGDTELPGFTLPGITSQEPGLEQENVVSLEGVTFQVPDAIQWEQQNQGLVRSWMEKLKDKAGYMSGMLVPVGVGIAGALFILGALYSIKVMNRRRRNGFKRHKRKQREFNSMQDRVMLLADSSEDEF
The following text describes a protein:
Function:
As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. May have a role in spermatogenesis.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle.
Sequence:
MLPSLQESMDGDEKELESSEEGGSAEERRLEPPSSSHYCLYSYRGSRLAQQRGDSEDGSPSGTNAETPSGDDFSLSLADTNLPSEVEPELRSFIAKRLSRGAVFEGLGNVASVELKIPGYRVGCYYCLFQNEKLLPETVTIDSERNPSEYVVCFLGGSEKGLELFRLELDKYIQGLKNNMNCEARGLESHIKSYLSSWFEDVVCPIQRVVLLFQEKLTFLLHAALSYTPVEVKESDEKTKRDINRFLSVASLQGLIHEGTMTSLCMAMTEEQHKSVVIDCSSSQPQFCNAGSNRFCEDWMQAFLNGAKGGNPFLFRQVLENFKLKAIQDTNNLKRFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHEEMPEAKNVIAVLEEFMKEALDQSF
The following text describes a protein:
Function:
May be involved in intra-Golgi transport.
Miscellaneous:
MISCELLANEOUS: Present with 2650 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MDTSVYSHALDIWAKADLTNLQRELDADVIEIKDKETLSLNSRKSLATETKKFKKLEPEEKLNNVNKIIKQYQREIDNLTQRSKFSEKVLFDVYEKLSEAPDPQPLLQSSLEKLGKIDDSKELKEKISYLEDKLAKYADYETLKSRLLDLEQSSAKTLAKRLTAKTQEINSTWEEKGRNWKEREADLLKQLTNVQEQNKALEAKISKNIDIEGNGNEDGDQENNQKEVSTRIAEYNLVTQELETTQARIYQLEKRNEELSGALAKATSEAEKETELHAKELKLNQLESENALLSASYEQERKSTSHAINELKEQLNSVVAESESYKSELETVRRKLNNYSDYNKIKEELSALKKIEFGVNEDDSDNDIRSEDKNDNTFESSLLSANKKLQATLAEYRSKSTAQEEERNELKKSVDQLKQQIATLKEANEKLETDLEKVENVSPHFNETASMMSGVTRQMNNRTSHKMSPTSSIIGIPEDGELSGNQSTILPIVTKQRDRFRSRNMDLEKQLRQGNSEKGKLKLEISKLKGDNTKLYERIRYLQSYNNNNAPVNQSTERIDVESQYSRVYDESLHPMANFRQNELNHYKNKKLSALEKLFSSFAKVILQNKMTRMVFLFYCIGLHGLVFMMSMYVINISGYMTPEVGIVQSAKSSSNLNGGLGGAEKVAAGVGSVHGINR
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
Miscellaneous:
MISCELLANEOUS: Present with 1700 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MLNGEDFVEHNDILSSPAKSRNVTPKRVDPHGERQLRRIHSSKKNLLERISLVGNERKNTSPDPALKPKTPSKAPRKRGRPRKIQEELTDRIKKDEKDTISSKKKRKLDKDTSGNVNEESKTSNNKQVMEKTGIKEKREREKIQVATTTYEDNVTPQTDDNFVSNSPEPPEPATPSKKSLTTNHDFTSPLKQIIMNNLKEYKDSTSPGKLTLSRNFTPTPVPKNKKLYQTSETKSASSFLDTFEGYFDQRKIVRTNAKSRHTMSMAPDVTREEFSLVSNFFNENFQKRPRQKLFEIQKKMFPQYWFELTQGFSLLFYGVGSKRNFLEEFAIDYLSPKIAYSQLAYENELQQNKPVNSIPCLILNGYNPSCNYRDVFKEITDLLVPAELTRSETKYWGNHVILQIQKMIDFYKNQPLDIKLILVVHNLDGPSIRKNTFQTMLSFLSVIRQIAIVASTDHIYAPLLWDNMKAQNYNFVFHDISNFEPSTVESTFQDVMKMGKSDTSSGAEGAKYVLQSLTVNSKKMYKLLIETQMQNMGNLSANTGPKRGTQRTGVELKLFNHLCAADFIASNEIALRSMLREFIEHKMANITKNNSGMEIIWVPYTYAELEKLLKTVLNTL
The following text describes a protein:
Function:
Required for endocytosis and endosomal pH regulation.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Note=Associated with the endosome/lysosome system.
Sequence:
MAPPEIGNDEIPLQEFGQKSFAADNTIGGMQSISYDNSGAPMGLYKEKKGMYVTARNLSMSIGTEKKGDKRNILSDLNFFLKPGSMVLILGSPGCGKTSVMKALANQLHSETVSGSLLFNGKAANKSTHHRDVAYVVQGDHHMAPFTVRETFKFSADLQMSEGTSEEEKNARVDYILKTLDLTRQQDTVVGNEFLRGVSGGQKKRVTIGVEMVKDAGLFLMDEPSTGLDSTTTLELMKHFRELSNVNQVSSLVALLQPGVEVTKLFDFLMIMNAGHMVYFGPMSDAISYFEGLGFKLPKHHNPAEFFQEIVDEPELYFEGEGEPPLRGAEEFANAYKNSAMFQSIVNDLDNTQPDLTFCKDSSHLPKYPTPLSYQIRLASIRAFKMLISSQVAVRMRIIKSIVMGLILGSLFYGLDLNQTDGNNRSGLIFFSLLFIVFSGMGAIAILFEQREVFYIQKDGKYYKTFAFFLSLIFSEIPIALLETVVFCVLVYWMCGLQANAEKFIYFLLMNFVGDLAFQSFFKMVSAFAPNATLASVIAPAALAPFILFSGFMAPKRSIGGWWIWIYWISPIKYAFEGLMSNEHHGLIYSCDDSETIPPRNTPNFELPYPRGSGNSSICQITRGDQFLDQLGMPQNNWFKWIDLLIVFAFGALFSFGMYFFLKNVHVDHRASDPKNDKRSKKASKRSKKIKDSKVDIKENRMVKAQKEIPIGCYMQWKDLVYEVDVKKDGKNQRLRLLNEINGYVKPGMLLALMGPSGAGKSTLLDVLANRKTGGHTKGQILINGQERTKYFTRLSAYVEQFDVLPPTQTVKEAILFSAKTRLPSDMPNEEKIKFVENIIETLNLLKIQNKQIGHGEEGLSLSQRKRVNIGVELASDPQLLFLDEPTSGLDSSAALKVMNLIKKIASSGRSIICTIHQPSTSIFKQFDHLLLLKRGGETVYFGPTGDKSADLLGYFENHGLICDPLKNPADFILDVTDDVIETTLDGKPHQFHPVQQYKESQLNSDLLAKIDAGVMPVGTPVPEFHGVYSSSYQTQFVELGKRSWLAQVRRVQNIRTRLMRSLFLGVVLGTLFVRMEETQENIYNRVSILFFSLMFGGMSGMSSIPIVNMERGVFYREQASGMYSIPIYLFTFIVTDLPWVFLSAIIYTVPMYFISGLRLDPNGAPFFYHSFISFTTYFNFSMLAMVFATVLPTDEIAHALGGVALSISSLFAGFMIPPASIAKGWHWFYQLDPTTYPLAIVMINEFQDLEFHCTSSESVTIPNVLTVNGTYIDVGPICPITNGNQILQRYEMKPEDKYKFLAVIFGYSVFFFICIFIALKFIRHQTK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion matrix. Cytoplasm.
Sequence:
MTAVFRVGLVRLVSRATQSPNLLQAQTNALPAAFQQRCSISGKTMRGGPRVPKAAPYPYKTKKYSVFNAIFDKTSKRFDENSKVICVEGPIAAGKSKFAKELAEELDMEYYPAVDLDLIYINSYGYDMRKLDPQLPPSCRSYDVRNFCLDPSHDLAAQFQIRMYMLRYSQYIDALQHVLSTGQGVVLERSPYSDFVFMEAMFRQGYLSRGARSVYNELRQNTIGELLKPHLVIYLDLPVDAVKKQIKARNVDYEVQSKVFSDAYLSDLEQLYKQQYLKDISTHAELLIYDWTAGGETEVVVEDIERIDFNQFEADIHNKKMLDWRFPLEAEWCEARIKYCHEKPDLMNYFNVPRFDVPELVRSADDGKVWRDVWFNAPGMKYRPGYNADMGDEGLLTKTKIGINQGI
The following text describes a protein:
Function:
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein.
Sequence:
MGTWVLLLPLLFAAEAQAQAQVCSVDKTSLTVKENTNPGEPLLDIYVPQGQQVTLGPSSTLFAFRIQGNQLFLNVTPDYEANTMLLAHLECRSGDSVVTQLRVFVSVLDVNDNPPRFPYETKLWEVPEDTRVNTTVISETELEAQDQDKDDVLFYTLQEVTLGASSFFSLVGANRPALRLDQSLDLERWPNMTFRLLARDTQEETTEPSHTATATLVLEVQPVDLRPPWFLPCSYSDGFVCIHAEYHGAVPTGHRLPDPLILHPGPVYAMDGDQGINQPIKYSIISGNEDSTFSISVDSGNLTMTKSIPNAKTFLLVVKGEQADNARYSVTQVTVEARNASGSMPHFTQSLYRGTVGLGSGAGVVVKDAADPSQPLRIRAQDPEFPDLNSAITYRITNNSDFRMDGEAVLTATSLEHAGVFYAEVEANNTVTSGTATTVVEIQIQPSPTGPPGPPTSPETAGTTRPSSGTTLEVPRPPEPSQGSSTTSSGGDTGLQPSPGTTLTSPASSMPSGPPSVGTSPSPPAASPSGGSATRPSSSPTSEAPQPPEPSQGSSTTSSGGDTGPHPSSGTTLRPPASSTPAPAGPPSVGTSPSPTTASPSGASAQTSTPTSPASSRNTWTPGTPETDGTEGRPVGGQAGDRRFSEAEMAVLGGVLGALLLLALIALAVLVYKNYGHRLTCGSGRALEPQPQGFDNQAFLNDSDDANWAPAPSPSPSHALPAPREPEPPEPAPPSPETPRRLPEAPAKAADGGSPAAVRSILTKERRPEGGYKAVWFGEDIGAEADVVVLNTPASEAGGAGDSGSEGSGDEAADAQDAPGTYSIHF
The following text describes a protein:
Function:
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex that is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to at least two telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand). Its activity is TERT dependent but it does not increase TERT activity (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA.
Sequence:
MPVQVLKIIKGKPETQLPSHLQREDLKHLQTGLDHTNKYFQGIVILSYPLTKLGDGTDFFKIVLQDDTCSRINSINVLMYGKMAEDCAKLIRNGDTFIVAGFKVAESPTAREDGRHACHLQVSEESGSAIFICTQPSITPFSEATSPSVAPKYVYTPLNCLKDGTVVNLYGIVKFFKPPYISKGTDYCSVVTLVDQSNVKLTCTLFNGNLDSLPKIYKNGDIVRFHRVKIREYNGQMQGITSAGFASLTFDGTVGAPVVPRASSKVYTFVDEEQKTVEELRIWAASNLSVSGPEAKLSDVKPMMFFDLTCQLVGKAKVDGSSFLLKVWDGTKCPYPTWKVPVEAKELEGDRVLLHHLRNLTVDVLVYDNHVQLAKSLKTGSFLRIYSIHTKQASAKNEDMSSHIEFHLHGGTCYGRGIGILPENNPDVEELKSFLECVELTDSQNMESVSSLELGDTFDSYTDLESPLQRCQQLSATVLTDHQDMSNTVLKTVLNSSAPQQYRIRAKLRSFKPQKLYQSVKLHCSKCNTLQEVPNGDAIDFILQGCAATAPNPELQSMSWYESVVWTTEEDQGRKITIHFVKHYEMLQRPENTLLMIEGGTLKEIWKLTRRFKCVIPVKSKEDDLELLDLSAPFLLQGNIKYYGCKKCSTPKSIKNLSSLAEKREPSWEPTEIAQVLGIEPLQYVFVMKFTLVDGTGVLNAYLFDYEKFFQIPASEILTNSFLQQKMEMTMNTLSPPGRKLDDLPWLECFIKSYNVADGMKHQVYYQIFDTTVAEDVV
The following text describes a protein:
Function:
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane. PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures. Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress. Involved in the regulation of the mating pathway. May be a receptor that feeds into the pseudohyphal growth pathway.
Miscellaneous:
MISCELLANEOUS: Present with 2330 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bud. Bud neck. Cell projection. Note=Localizes at the tip of the mating projection during conjugation.
Sequence:
MSISSKIRPTPRKPSRMATDHSFKMKKFYADPFAISSISLAIVSWVIAIGGSISSASTNESFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAFVYNTNSATNLVYADGPKKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGIRPSPLENSLHRARRRGNRNTTPYQNNVYNDAIRDSGYATQFDGYPQQQPSHTNYVSSTALAGFENTQPNTSEAVNLHLNTLQQRINSASNAKETNDNSNNQTNTNIGNTFDTDFSNGNTETTMGDTLGLYSDIGDDNFIYKAKALYPYDADDDDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLIDGPEEMHR
The following text describes a protein:
Function:
Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MRSHLARNATTTTPNVYRRLHAAVGHHHGLLRPCSATALSARRCLFDCQHDVAHIPRDVALCTRTSKRTFISLFTPKPERFVKLPHFDPGYNVLLQYRKSEVEQERPPPRDQLVTAFKKLTKFKADTNRPLNPNQAFLLRTVLHYLLVTKPEADAPVDLKMSDLENAMDAALLPPKGSPEFHLALARLLHEEIMRRRLILLNPEERKVHLTKDDFARYIKALTQYGGSLEAAGRVKEFWQQLKDERSAVYFRGSGRIWIMVLEGLANEGREEELLQFWEEAQETGGIKYIPGVHQIFVTYYARQDKIEETKQWYSKPIHSGFSPTGETLLELVRSSRRSSQKWNEWLLPVFEQVVQDKFAKKGSLDAFLQWSVLALDKGPDGIKTYLQTMASGDFYQSHEVKVDATTINRLMQAAQEKGNPYMAERFWQLAQDFNIKANVHTYLNQMSYRLDANDIEGAHQIFSKLASGAVEVEFDEDLPVMNKYLRVLCAQQEPNIQHILTITSALEQRHAVLEPETIVALCLVFLNHDKKFDVIDTLSLHSVSISHIERQQIYKAFVDYICSPQTTTDRAWDAYSLLRQYFPETSVDDRVRLMESFFERKKPDMACLVFGHMRAHDDDNMHPTADIYVRCLEGLGRCPIPEQRPSDPASSLKMVHNMLKMDTRVEMNTRLYNALMLAYAAGGDPFTALDFWEEHITRSAEGPSYNSLAIVFWCCELIPLGDRYARPVWQKMLRMDLEVPQLGLTYNALPDPVSKDEFAAWAKEEYPEEWARLESKGQKETEFQGPVFNITRLFEA
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MLELRLVQAASLKNVLEALSVLDLSSEVNFEFSGTGFELQAMDTSGAALVALLLRADAFNHYLCDRDLSMGLNLADMANVFRCANNDDILTIKVDGCPDTVMFVFESPKVGEISYFDLHFVDINRMPCEIPEIPESEYQAIVRMPSAKFMRICKKLSSVGDREDRDTVASISVDKERVDFFTSGKAGTSTIFCTVGKPKEPTLIEEPTLIEMKEKVSLSFDLRYVNSFSKMCTQSDQQVTISLSPELPVLFEYKITEMGRIRYYVAPRIKLQNEVDGMQN