lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MERCSRCHRLLLLLPLVLGLSAAPGWAGAPSVDVLRALRFPSLPDGVRKSKGVCPADVAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVRTRSGLQAPLLTLYSAQGVQQLGLELGRPVRFLYEDQRGRPQASAQPIFRGLSLADGKWHHVAVAVKGQSVTLIVDCKKRVTRPLPRSVHPVLDTHGVVIFGAHVLDDEVFEGDVQELLIVPGVQAAYQSCGQKDLECEREQRDGPQTQKPHRAQRSPKKEPARLHKPQNQEPQQQPTESLYYDYEPPYYDVMTTETSPDYQEQTDLQVPPTADSFQAEEYGEGGTEPPAGFYDYTYGYGDDYREETELGPALSAETDHTGAVAHGPRGLKGEKGEPAVLEPGMFVEGPPGPEGPAGLAGPPGIQGNPGPVGDPGERGPPGRAGLPGSDGPPGPPGTSLMLPFRFGSSGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGEPGVKGDRGFDGLPGLPGEKGQRGDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPHGPKGSLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPRGKPGLPGMPGSDGLPGHPGKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDGPEGPKGRTGPTGDPGPTGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPAGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGESGPMGERGHPGPPGPPGEQGLPGTAGKDGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPAGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPFGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGVQGEPGVKGPRGERGEKGESGQAGEAGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEAGPRGQDGAKGSQGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGTPGPEGRQGEKGAKGDPGAVGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPTGEQGEKGDRGLPGPQGSPGQKGETGIPGASGPIGPGGPPGLPGPSGPKGAKGATGPAGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSKLMQDEEATPTGGAPGSPAGLEEIFGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCARDAFRVFCNFTAGGETCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSGVSQDGPLKLRGANEDELSPETSPYVKEFRDGCQTQQGRTVLEVRTPVLEQLPVLDASFSDLGAPTRRGGVLLGPVCFMG
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MDVEGRASKGKPLTLNLEQGQEKGTQNDDYGLASAHSIDRDSWQQVGLMLVTSFNCGWILSFSNLCLWPLGWTWGIICLIVVGFYTAYANWLLAAFHFIDDRRFIRYRDLMGYVYGKSMYHLTWVFQFLTLLLGNMGFILLGGKALKAINSEFSDSSLRLQYYIVITGAAYFFYSFFFPTISAMRNWLGASALLTFTYIIFLLIVLVKDGKSNSNRDYDISGSEVSKIFNAFGAISAVIVTNTSGLLPEIQSTLRKPAVKNMRKALYLQYTVGVLFYYGVTVIGYWAYGTMVSAYLPENLSGPKWINVLINAIVFLQSIVSQHMFVAPIHEALDTKFLEIDKPMHSGENLKRLFLLRAFFFTGNTFVAAAFPFMSDFVNFLGSFSLVPLTFMFPSMVFIKVKGRTARIEKKAWHWFNIVFSFLLTIATTISAVRLIVNNIQKYHFFADA
The following text describes a protein:
Function:
May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation. May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Multi-pass membrane protein. Nucleus, nucleolus. Postsynaptic cell membrane. Recycling endosome.
Sequence:
MLRAAAAGKEGVPPGVCDLATSLPEVPEGPLWSWRSRALGSAAGKAGAMALIEGVGDEVTILFSALACLLVLALAWVSTHTAEGADPLPQPSGTPTPTQPSEAMAVTDSIRGEAPGAETPGLRHRGQAAPPEPSVGLAATPPPPDSPQEPLVLRLKFLNDSEQVARAWPHDTIGSLKRTQFPGREQHVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPLPPCPPGSEPGPSGLEVGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP
The following text describes a protein:
Function:
Essential for mesoderm formation and axial patterning during embryonic development.
Subcellular Localization:
Secreted.
Sequence:
MSAHSLRILLLQACWALLHPRAPTAAALPLWTRGQPSSPSPLAYMLSLYRDPLPRADIIRSLQAQDVDVTGQNWTFTFDFSFLSQEEDLVWAELRLQLPGPMDIPTEGPLTIDIFHQAKGDPERDPADCLERIWMETFTVIPSQVTFASGSTVLEVTKPLSKWLKDPRALEKQVSSRAEKCWHQPYTPPVPVASTNVLMLYSNRPQEQRQLGGATLLWEAESSWRAQEGQLSVERGGWGRRQRRHHLPDRSQLCRRVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLEHHKDMIVEECGCL
The following text describes a protein:
Function:
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSKYPRSVRCCLPLCALTLEAALILLFYFFTHYDASLEDQKGLVASYQVGQDLTVMAAIGFGFLTSSFRRHSWSSVAFNLFMLALGVQWAILLDGFLSQFPPGKVVITLFSIRLATTSALSVLISAGAVLGYVNLVQLVVMVLVEVTALGTMRMVISNIFNTDYHMNMMHFYLFTAYFGVTVAWCLPKPLPDVKEDKDQIATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFNTYYALAVSVVTAISGSSLAHPQGKISMTYVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLVAGLISIGGAKCGPGCCNRVLGIPDSSVMHYNFSLLGLLGEIIYIVLVVRHTVWNGNGMIGFQVLLSMGELSLAIAIALTSGLLTGLLLNLKIWKAPHVAKYSDDQVFWKFPHLAVGF
The following text describes a protein:
Function:
May play a role in the division of some cell types.
Sequence:
MDPKATSTSKTDNIDQITIIEEKVNKIGTEPTIRKYSKGRMLGKGGFAKCYEVTNLENKKVLAGKIICKASLTKSRAKQKLISEIKIHKSLRHSNIVEFEHVFEDQENVYILLELCPNQSLHDLIKRRKRLTEIEVQCYTLQLICGLKYLHSRRVIHRDLKLGNLLLNDKMELKICDFGLAAKLEFDGEKRKTVCGTPNYIAPEVIEGKGGHSYEVDTWSLGVIIYTLLVGRPPFETSDVKQTYKRIKACEYSFPDHVSVSDTAKNLVQKMLTLDPSKRPSLDEILQHPFLKNANNIPKFLPASTLACPPSTSYLNQFASPENSVKVPSQPAPKSAEATPLAAQKNGRFINTQGSNMFGSEKTLVTSPHSATTQAHTNENVVLTSQLDRHQTQGEKGWNFTKTGSWQSNLNGTQSVKGSSRPQTVQQKGDLKSAQSLKAPALLNNLGSRLRVSGSAVGSNRGQVLSGNEVWVKKWVDYSSKYGMGYNLSNGTTGVFFNDNTKIVFNQKTDQVTYIQRGKNDRQDTVTHYSLTEYPKDLQKKMTLLQHFKKYLEGSEYGGSESINDGTETQIGVYVKKWVKTKNATLFRLSNKTVQVHFTDRTEIILNSENKQVTYVARKETEPISP
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAHPAQLGLQDASSPIXEELLHFHEDALMIVFLISTLVLYIITTTVST
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
Miscellaneous:
MISCELLANEOUS: Present with 33100 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Note=Associated with ribosomal chromatin, even in the absence of transcription.
Sequence:
MDSPVLQSAYDPSGQYLCYVTVALDKQRVGVQPTQRATSSGVDTVWNENFLYLEDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFTTGNSYEIKDIDLMGNQLWCIDSSDAFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVASHSISLIDIEEKKVVMTFPGHVSPVSTLQVITNEFFISGAEGDRFLNVYDIHSGMTKCVLVAESDIKELSHSGQADSIAVTTEDGSLEIFVDPLVSSSTKKRGNKSKKSSKKIQIVSKDGRKVPIYNAFINKDLLNVSWLQNATMPYFKNLQWREIPNEYTVEISLNWNNKNKSADRDLHGKDLASATNYVEGNARVTSGDNFKHVDDAIKSWERELTSLEQEQAKPPQANELLTETFGDKLESSTVARISGKKTNLKGSNLKTATTTGTVTVILSQALQSNDHSLLETVLNNRDERVIRDTIFRLKPALAVILLERLAERIARQTHRQGPLNVWVKWCLIIHGGYLVSIPNLMSTLSSLHSTLKRRSDLLPRLLALDARLDCTINKFKTLNYEAGDIHSSEPVVEEDEDDVEYNEELDDAGLIEDGEESYGSEEEEEGDSDNEEEQKHTSSKQDGRLETEQSDGEEEAGYSDVEME
The following text describes a protein:
Function:
RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (By similarity). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation. Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (By similarity). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen. Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL. May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (By similarity). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (By similarity). May be implicated in HOX gene regulation (By similarity).
Subcellular Localization:
Nucleus speckle. Nucleus, nucleoplasm. Nucleus envelope. Nucleus membrane; Peripheral membrane protein. Note=Colocalizes at the nuclear pore with DBP5 and NXF1.
Sequence:
MRSAGREPLPRRSPRWRRASPLCETSAGWRVSQLRRDDLRRPSTMKGKERSPVKPKRSRGGEDSSSRGERSKKLGGSGGSNGSSSGKTDSGGSRRSLHLDKSSSRGGSREYETGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGVEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDAYAPSSSVVGTSVGSHRHAPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRELERERDYPFYDRVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDTFGHRAPDPLRSARDRTPPLLYRDRDRDLYTDSDWVPPPPPVRERSARAATSAVTAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESERPRKQRHCTPSPDRSPELSSNRDRYNSDNDRSSRLLLLERSSPVRDRRGSLEKSQSDKRDRKNSASAERDRKHRTAAPTEGKNPLKKEDRSDGNAPSASTSSSKQKPPSQKQDGGTAPVAASSPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSATSDTAASTQRPLRNLVSYLKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRAKLVNSG
The following text describes a protein:
Function:
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Prefers double-stranded DNA over single-stranded DNA as substrate.
Miscellaneous:
MISCELLANEOUS: Present with 150 molecules/cell in log phase YPD medium, but not detectable in stationary phase cells; MISCELLANEOUS: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.
Subcellular Localization:
Nucleus.
Sequence:
MKELLYYTFIETEVTGAFLVFREKTQNLVFASLGNDKLFLLGKVEGFLKKHEKQDTMYDLQELKEAETYKKSIENYTICLENKMPLPSGAIPFEFLFGTDFQRKVWNELLNVEHGHVVTYGDIAKRIGKPTAARSVGRACGSNNLALLVPCHRIVGSNRKLTGYKWSCKLKEQLLNNEKENSLSLSRL
The following text describes a protein:
Function:
GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. Also required for TORC1 inactivation during nitrogen starvation. Required for intracellular sorting of GAP1 out of the endosome. Functionally associated with the inorganic phosphate transporter PHO84, and may be involved in regulating its function or localization.
Miscellaneous:
MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MSSNNRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDVEHSHLRFLGNMTLNLWDCGGQDVFMENYFTKQKDHIFQMVQVLIHVFDVESTEVLKDIEIFAKALKQLRKYSPDAKIFVLLHKMDLVQLDKREELFQIMMKNLSETSSEFGFPNLIGFPTSIWDESLYKAWSQIVCSLIPNMSNHQSNLKKFKEIMNALEIILFERTTFLVICSSNGENSNENHDSSDNNNVLLDPKRFEKISNIMKNFKQSCTKLKSGFKTLILNNNIYVSELSSNMVCFIVLKDMNIPQELVLENIKKAKEFFQ
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRMLPSYIPSPPRGVWYLGPLPVRAYAVCVITGIIVALLIGDRRLTARGGERGMTYDIALWAVPFGLIGGRLYHLATDWRTYFGDGGAGLAAALRIWDGGLGIWGAVTLGVMGAWIGCRRCGIPLPVLLDAVAPGVVLAQAIGRLGNYFNQELYGRETTMPWGLEIFYRRDPSGFDVPNSLDGVSTGQVAFVVQPTFLYELIWNVLVFVALIYIDRRFIIGHGRLFGFYVAFYCAGRFCVELLRDDPATLIAGIRINSFTSTFVFIGAVVYIILAPKGREAPGALRGSEYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDDPAEPDGIRRQDDFSSRRRRWWRLRRRRQ
The following text describes a protein:
Function:
Histone methyltransferase which contributes to the establishment of heterochromatin by specifically methylating histone H3 to form H3K9me. Part of the Clr4 methyltransferase complex (ClrC). ClrC preferentially ubiquitylates H3K14 and ClrC-mediated H3 ubiquitination promotes clr4 methyltransferase activity. Clr4 functions as a reader and writer of H3K9 methylation. It sets the H3K9me mark and afterwards this H3K9me mark is recognized by the chromodomains of clr4 and swi6/HP1, which then recruit additional clr4 leading to the methylation of neighboring nucleosomes. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeres, ribosomal DNA repeats, and the silent mating-type region. Clr4 methyltransferase activity promotes the assembly of a tripartite complex composed of ClrC and complexes involved in siRNA generation. Apart from H3K9, also methylates non-histone proteins such as mlo3. Interacts with mlo3 to promote the processing of centromeric and antisense RNAs.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Chromosome.
Domain:
The chromodomain serves to recognize and bind to H3K9me; In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MSPKQEEYEVERIVDEKLDRNGAVKLYRIRWLNYSSRSDTWEPPENLSGCSAVLAEWKRRKRRLKGSNSDSDSPHHASNPHPNSRQKHQHQTSKSVPRSQRFSRELNVKKENKKVFSSQTTKRQSRKQSTALTTNDTSIILDDSLHTNSKKLGKTRNEVKEESQKRELVSNSIKEATSPKTSSILTKPRNPSKLDSYTHLSFYEKRELFRKKLREIEGPEVTLVNEVDDEPCPSLDFQFISQYRLTQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLDDLDEPTHFAYDAQGRVRADTGAVIYECNSFCSCSMECPNRVVQRGRTLPLEIFKTKEKGWGVRSLRFAPAGTFITCYLGEVITSAEAAKRDKNYDDDGITYLFDLDMFDDASEYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRNHGFRTIYDLAFFAIKDIQPLEELTFDYAGAKDFSPVQSQKSQQNRISKLRRQCKCGSANCRGWLFG
The following text describes a protein:
Function:
Required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover) and works cooperatively with MER3 to promote crossovers.
Subcellular Localization:
Nucleus. Chromosome. Note=Detected in punctuate foci onto the chromosomes in prophase I meiocytes.
Sequence:
MKISELSPEYREPPSHAGLIADLSKAVSDVESFAASATAPEKLAADLRRILTSLASAASSSSFTESLSVQIWRLGTRLWNAVVDRANSAALAGGPAALAVEAEIRQAAPELLLLAGIPNGVPSAAAKVASFFHRSGLAWLDLGRVDLASACFEKATPLVSAAATEDRGVLLELNLARARAASDAGDQALAVALLSRSKPLAAASPEGAKSLAQGYLSIGEATLAAKHSNPAVEASTLFTEALDLCEKAASPSSSSPRTPPYGGATPKTPNLEGLKRRCLRFLALERLQAQDYEGVLRCIRVSRASMGLEEEHPSIGVMAMRAWIGSGNMAEADKELERLMANALATENLCVSAAEAYLAAAGPEAARKVLIALAARCRAGGAAAAVRVVKQVIDGGGGGIGRARAIAELVSDERVVALFDGPGNTHERGTMHALLWNCGTEHFRAKNYDTSADLIERSMLYVSRDEESRSRRADCFRVLSICHIALQHLDRALEFVNEAYKVEPNIKCAFLKVKINLQKGEEDEAFKQMKTMVGCVDFNPEFLTLTAHEAMSCKSFGVAVASLSYLLGLYSAERPMPMPEVAVLRNLIELLSREPGTEAEILKYSRRAKQRMADLGVESFFGSGIVGGRELNWFADLSWNMGLRASKEKKYNFGAEFFELAAEFFSSRNAECDENRSKVCKALIMAVTIMLNAEELNNSPLSDSDIKKGVEMLSRAGKLLPLISPSVPVASDQLEANNFLYLHTFNSYQLMGRMGTPAHPQQLQLIKNFASSKACTPANLLTLGVTASKGALPNMLAAEFSLKACITTALASQSPNYRVISCALRKLACLAGLQDLNGSKSDAAYDVFQQAYQIVVGLKEGEYPVEEGQWLVATAWNMSCLPLRLHQAKVARKWMKMGLDLARHLEGMKERIASMQTTFENFERVSGDEPDECSQEEAPKASISGSMSQPVLV
The following text describes a protein:
Function:
May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.
Sequence:
MAGGGGGSTSGEGPRELDQTPTWAVSTVCGVIILISIVLELMIHKIGEVFTERRKKALYEALQKIKNELMVLGFISLLLTFGQNYIASLCVASRYGHAMSFCGPYDGPSGESKKPKTTEHLERRVLADAAPAQCKKGYVPLISLNALHQVHIFIFFLAVFHVIYSAITMMLGRAKIRGWKVWEEEVINDHEMMNDPSRFRLTHETSFVREHVNPWAKNRFSFYVMCFFRQMLRSVRKSDYLTMRHGFISVHLAPGMKFNFQKYIKRSLEDDFKVVVGISPELWAFVMLFLLFDVHGWYVTAVITMIPPLLTLAIGTKLQAIISDMALEIQERHAVIQGMPLVNVSDRHFWFSRPALVLHIIHFILFQNAFEITYFFWIWYEFGLRSCFHHHFALIIIRVALGVGVQFLCSYITLPLYALVTQMGSTMKRSVFDDQTSKALKNWHKNAKKKSETPGQTQPPLPNLRPKTGGDIESASPANITASVDVKESDQSQSRDLLSGP
The following text describes a protein:
Function:
Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.
Sequence:
MRIHILGICGTFMGGLAMLARSLGHEVTGADANVYPPMSTLLENQGIDLIQGYDPAQLNPIPDLVIIGNAMTRGNPCVEAVLEQGIPYVSGPQWLHDHVLPERWVLAVAGTHGKTTTAGMLAWILEACGYEPGFVIGGVPGNFDVSARLGNSPFFVIEADEYDCAFFDKRSKFVHYSPRTLIMNNLEFDHADIFDDIKAIQKQFHHLVRLVPGKGKIILPDNDNHLKQVMAMGCWSEQELVGETGSWFARKVSTDASVYEVLLDNNVVGEVNWSLVGEHNMHNGLMAIAAARHVGVLPADACRALGDFINASRRLELRGEAHGVTVYDDFAHHPTAILATLAALRSKVGGTARILAVLEPRSNTMKLGLCKNELAPSLGRADEVFLFQPQHIPWQVVEVAEACIQPAYWSADIDQLVDMIVKTAQPGDHILVMSNGGFGGIHDKLLSALDKKAEQATALF
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAVEETVKGNSFLGLVLLKDEENEKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKIESFVNKDPLVARVSYPEEEPGAPKNTTKAIMRTLLVMTRELAQNNPLFTEEMKLTMLNVNEPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDKIDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFSYADPNTGDYNVIRNYLDILESLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLAVKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFRFSVGGMRDEAEIKGHRRTYIGSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDLPFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTPYGIEFDKKAIVALIDSYSRESGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFLGVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVKGKGGILLTGMLGKTMEESSNIALSYIKNFLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGMTGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRYEEVALLLFDEKVISKINPSFRENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MADSDGEYASDDELKRHGKRTADGRSKQTKASWEDVKRSWDTVLETADSGLSIAEIREAEKRRRLLRDTTPLQRGIIRHLMLVLDMSFAMADKDLLPNRYRVVLNNAIGFVREYFEQNPISQLGIVGMRDGIAVRISDLSGNPAEHIEKLMQWSEQQDPQGNPSLQNALQMCRGALYQTPSHATREILIIYGALVSIDPGDIHDTINDLVADRIRVSVVGLAGQVAICSELCKRTNNHDGNYSVAVDEVHLKELFFAATTPPVTRTPEQNTASLLMMGFPSRTLAPKDHVSFCACHAKPTREGYTCPRCGIKVCRLPIDCPICKLTLIQSTHLARSYHHLFPLKVFVEVPWSQAYKSTACYSCLTPFPARPRDSVAAAPAVLGGRAGAKGSGKQQDGEQKNPKPELKGVSESGRYACQVCGNHFCIDCDVFAHETIHNCPGCQSDTRDVEKDTAVAVPDGGPTPMVMDS
The following text describes a protein:
Function:
Possible role in the specification of a distinct subset of neurons.
Subcellular Localization:
Nucleus.
Sequence:
MATSGRLGFTVRSLLNLPEQDAKPRVRREQQTCVPQTAAWLESECSHYLSSDESGLETSPADSSQLASLRRESPGSDPEKRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRLTPTQVKIWFQNHRYKLKRGRAPGITEPSDMAASSDLHAAPGLLRRVVVPVLVHDRPPSNNGRGEGTSAVPQDKCSARLATACPVPGYTAFGPGSALGLFPAYQHLAPPALVSWNW
The following text describes a protein:
Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MSVVGFDVGNENCVIAFAKQRGIDVILNDESKRETPAVVSFGEKQRFIGSAGAASATMNPKSTISQVKRLIGRKYREPAVQMDLKLLPFATSEGPDGGILIHLQYMNEKQSFTPVQIMAMLFAHLKQIAEKNLEMDVSDCVIGIPSYFTDLQRQDTKEXDFEKLSSDLLEKISIPCRKALLDSGLTADRIHTLELVGSGSRIPAVGRILNSLFRKEPGRTINASECVARGCALQCAMLSPIFRVREYEVQDSFPFSIGFASDEGPVCTLSNGILFPKGHSFPSMKVLTLHRSSCFNLEAFYTNQNELPPGVSDKISKSTIGPFQVPHSEKAKIKVKIQLNLHGIVTVESAWLIKDQTSHSTSENNTDTHAEDMEGDDTRKSKAVKRQDIPVSESVNGGMTLAELSQAQEKECQLAEQDIKVERTKDKKNTLEAYVYETRNKLLNTYRSFATDSEREGISCNLQQTEEWLYEDGDDESEHVYAEKLDDLKKMVDPVENRYKEEEARAQATRNLLNSIVEYRMAAGSLAASEKDAVINECHKAEQWLREKSHQQEALPRNADPVLWSSEIKRKTEAFEAMCKHVMRHKSSPQKTEDGSGSDPRSKREDDMDVD
The following text describes a protein:
Function:
[Ubiquitin-like protein]: Involved in the ATP-dependent selective degradation of cellular proteins, the maintenance of chromatin structure, the regulation of gene expression, the stress response, and ribosome biogenesis; [NEDD8-like protein RUB3]: Appears to function as a stable post-translational protein modifier.
Miscellaneous:
MISCELLANEOUS: Synthesized as a precursor protein containing a N-terminal ubiquitin-like protein fused to the ubiquitin-related protein.
Subcellular Localization:
[Ubiquitin-like protein]: Cytoplasm. Nucleus.
Sequence:
MQIFVKTLTGKTITLEVESSDTIQNVKAKVQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGLNVKVRTLTGKEIDIDIEMTDTVDRIKERVEEREGIPPVQQRLIYGGKQLADDKTAHDYKIEAGSVLHLVLALRGGNF
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Sequence:
MRFLSILYLCFAAIFSSSYAAELVKEDTGSDIWKSIESATTCAGCNAVLLLLKGVAHLGNDAFVDTLTEICKLAGVEDADVCAGAIGLEGPIIAHDLRQMTIGTETSKLFCITFFGLCDYPAVTPYTVPFPSAKPATRRPAASGKTPIKIVHFSDIHVDREYEVGANSNCSKPICCRSYTSADAPGNNSYPAGEWGNYKCDATLSLEESMYAAIKEVAPDATATLFTGDIVEGSVWLVNSTTNIADINDAYSRMSGLTKIFAATGNHESAPVNSFPPDAVGVSTYQWVYDTLSTNWKAFIDPTAASSADSFGAYSTLLPGSNLRIISINTNLYYRSNYWLYEATMEKDPSGQLAWMVTELQAAETAGERVYIIGHMPMGSNDVFHDTSNYFNQITQRYSATIAALFFGHTHRDEFQITYSDYTAQTAANALEVSYIIPSMTPTSGYPTFRVYTVDPVTYGVLDFTNYIAEFDLTASTQSAPTWKPYYSAKAAYGPLVTPPLTSDTAELTPAFWHNLTTVFAENPSVFNQYISRKTRGYNVETCSGDCATQEICQIRAAESQYNCATIKPGIHFRKRSEGDGTLERRIGNVVDNFGGECEGSAIRPILTKLAGQQGLLESALERAKAKAKARK