lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).
Sequence:
MPDTKMYDSSQIMNSMPKAELHAHLNGSLSLLTIRKLIDLKSSHNCEDVHNLESIITKLCDEKHNKTLDECFEVFKIIHQLTDSEKSIYIATVDVIKEFAEENVRYLELRTTPRAIDGSLDTYVDAVIRAIDDCRKEKVPILVKLLLSIDRSRGVEIAKKIVDLTISLGHARKDVVIGLDVSGNMAQSNVTDYFPLLHKIKEAGLKLTVHTAEIRNDAETEAILRLKPDRIGHGTFISPSLIGSPHLLGLLKENNIPVELCLTSNIVCKTVPRYQDHHLKIFLDHGIPFSICTDDKGVFSTSLSQEYLIAFRTFNFTLSSMWSFSRKSLDYTFATENEKEQLKKIWKEWEHENVDLNLVNSQETNE
The following text describes a protein:
Function:
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MAKLVNKLVDSFDHDEAPAPDVGCVRAVLAELVLTFLFVFTGVSASMAAGAGGKPGEAMPMATLAAVAIAHALAAGVLVTAGFHVSGGHLNPAVTVGILVRGHITKLRALLYVAAQLLASSLACILLRYLSGGMVTPVHALGAGIRPMQGLVMEVILTFSLLFVTYAMILDPRSQVRTIGPLLTGLIVGANSLAGGNFTGASMNPARSFGPAMATGVWTNHWVYWIGPLLGGSLAGFVYESLFMVNKTHEPLLNGDI
The following text describes a protein:
Function:
Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5.
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Chromosome. Cytoplasm. Note=Colocalizes with cdc-48.1 to the perinuclear region in spermatocytes. Localizes to the nucleus during S phase in a cdc-48 and npl-4-dependent manner.
Sequence:
MDLTASLEDDQREKLRQYTEFTHQQDYEVAIGTLASLNWNLEQAIEAHLMQEDKNDDEDPEILETIPAAASGRNAGASSSSRFEPEVINIEDDEMPATRGRRRGRAVTPDETTTVDNQVKRLRIDDGSSSSSNGAATHHRGAAIPRQKRGQATEPTPSSSGSSSASFSSRRGTRANPVPPPNQEPAHPESARQNGGILASRHNNHNNQQNNHHHHHQRIPINPRRVDVFNVDSDEDDDSMAIAYEDDDDGVHEVHHSEVVARGSGPPNGRIPMIPDGFSSVSDALRNFVAIFSDRFCSTPQTQAFMPPFYTEPLPAAVKEAFDHPNSEHRRPLLFYINHDRSIAANIFASQVLCSETVSTLIRHQYVLFPWDITSDSNLMLFLEYLQAANMGDVRTIIQRLAMSKIESFPLMAIVVKERNSYRLVDYCRGTDTSDQVMEKLLSGVSEYSDIRMNEQSERREREEREAIRNQQEAEYKASLAADKARMEAKQQEIEEQRLEEERKLREEEEECVRRQTVASTVPEEPPASAPLAEIINVKFRLPEGGQDMRRFRRLESIQTLINYLSSKGYSPDKFKYFNSDFPKKEITRHFDLSHNFADTKWPAREQIFVEEI
The following text describes a protein:
Function:
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGKKRTASSNRWMLEHFDDHYVKLAQKRGLRSRAAFKLEELQQKDQLIRPGMTVVDLGAAPGGWSQVAVKLVGDKGKVIACDILPMDPIVGVDFLQGDFREEKVLEALLTRVGADKVDVVLSDMAPNMSGSDGVDQPRAMYLVELALDMCHQVLAPNGSFAVKVFQGEGFDEYMKAVKEAFKVVKTRKPDSSRARSREVYLVATGYKL
The following text describes a protein:
Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MFPRPLTPLAAPNGAEPLGRALRRAPLGRARAGLGGPPLLLPSMLMFAVIVASSGLLLMIERGILAEMKPLPLHPPGREGTAWRGKAPKPGGLSLRAGDADLQVRQDVRNRTLRAVCGQPGMPRDPWDLPVGQRRTLLRHILVSDRYRFLYCYVPKVACSNWKRVMKVLAGVLDSVDVRLKMDHRSDLVFLADLRPEEIRYRLQHYFKFLFVREPLERLLSAYRNKFGEIREYQQRYGAEIVRRYRAGAGPSPAGDDVTFPEFLRYLVDEDPERMNEHWMPVYHLCQPCAVHYDFVGSYERLEADANQVLEWVRAPPHVRFPARQAWYRPASPESLHYHLCSAPRALLQDVLPKYILDFSLFAYPLPNVTKEACQQ
The following text describes a protein:
Function:
Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing, translation and export (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (By similarity). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (By similarity). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity).
Subcellular Localization:
Nucleus speckle. Note=Promotes formation and localizes to paraspeckles, a nuclear membraneless organelle.
Domain:
The C-terminal disordered region undergoes liquid-liquid phase separation (LLPS) for the formation of paraspeckle membraneless compartment.
Sequence:
MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAAAAAAEPYPVSGTTKRKYQEDSDPERSDYEEHQLQKEEEARKVKSGIRQIRLFSQDECSKIEARIDEVVSRAEKGLYNEHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSSTLPPSYASDRLSGNTRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCPEAASSPTRKVKMRRH
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. This major G-protein of the squid photoreceptor is involved in visual transduction. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSESQLKKVLKENETLKAQLEKSTTILKVSEACESLQDYCTKTSDPFIPGWSGENEWTKPLKGNGCSVL
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSVLSKHPLNSLKINSRLIQTCEDKLQVKTYSHVQYAAIPEILQEKDCLVKAQTGSGKTLAYLLPTITMILNKHPKLKRTDGLFCLILTPTRELTQQVYDVLTILTTSIIGLVPSIVVGGDSKKSEKARIRKGVNILVGTPGRLLDHINSTNNLKLDKVEFLIMDEADRVLDAGFEKDVIEIINHVNKNRTSILVSATLTESVKKLSNLALKNPVFIDGDKRENAKERKKLKLIKEEENNQEKTEKIINEDKIEDKLILPSTLKQYAMLITDKYRLAYLIACLRTFLKESIQRKIIVFFSCIQSVNYHYSLFSQLQFMDKTPILPETSLFRLHGDLTTVERHDGMQKFIKSKKAVLFTTDVAARGIDLKDIDWIIQYDPPGETSEYIHRVGRTARIGRNGNSLLMLLESEGEYVNLLRNEGVIIEEMKRDEVVKSLNMAGGDKKVISRLHEMQLQVEKLLIDNEELKEMAIKSFQAHLRSYTTHRGELRKIFSIKKLHIGHICKSFGIRDTPTSVMSVIKKQDGFLTKPKEKKKELKEGMRKMSEFDAGIITKKKKKR
The following text describes a protein:
Function:
Probable N-terminal protein acetyltransferase.
Sequence:
MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYTVEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDKAHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNVKINGVWEDHQVLAILNPDDEQ
The following text describes a protein:
Function:
Involved in chitin degradation. Catalyzes the oxidative cleavage of glycosidic bonds in both alpha- and beta-chitin via a copper-dependent mechanism, leading to oxidized chitooligosaccharides with a dominance of even-numbered products. Acts synergistically with the chitinase EfChi18A, and combining the two enzymes leads to rapid and complete depolymerization of crystalline chitin, especially with beta-chitin as a substrate. Is likely involved in a chitin degradation pathway that allows E.faecalis V583 to grow on chitin as a carbon source.
Subcellular Localization:
Secreted.
Sequence:
MKKSLLTIVLAFSFVLGGAALAPTVSEAHGYVASPGSRAFFGSSAGGNLNTNVGRAQWEPQSIEAPKNTFITGKLASAGVSGFEPLDEQTATRWHKTNITTGPLDITWNLTAQHRTASWDYYITKNGWNPNQPLDIKNFDKIASIDGKQEVPNKVVKQTINIPTDRKGYHVIYAVWGIGDTVNAFYQAIDVNIQ
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MELLLLYSSSLALLLLSSQGLRSTEGRDLHYQPKEEPPAAPKVKAEEEGAVMAASAAMIGSRPPRCEGRCALCGRCEAVQVPVAPRDKGHFRLARAFGGDGADESSTNYKPLNWKCRCADRRIFNP
The following text describes a protein:
Function:
Regulation of fluid secretion. Stimulates primary urine secretion by the Malpighian tubules. Increases the frequency of contraction in the heart and hindgut. Causes a dose-dependent stimulation of cAMP levels in the dorsal vessel and hindgut, but not in Malpighian tubules. Has synergistic effects on urine secretion by Malpighian tubules with serotonin.
Subcellular Localization:
Perikaryon. Cell projection, dendrite. Cell projection, axon. Secreted.
Sequence:
GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP
The following text describes a protein:
Function:
SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MNALYNHAVKQKNQLQQELARFEKNSVTAPISLQGSISATLVSLEKTVKQYAEHLNRYKEDTNAEEIDPKFANRLATLTQDLHDFTAKFKDLKQSYNENNSRTQLFGSGASHVMDSDNPFSTSETIMNKRNVGGASANGKEGSSNGGGLPLYQGLQKEQSVFERGNAQLDYILEMGQQSFENIVEQNKILSKVQDRMSNGLRTLGVSEQTITSINKRVFKDKLVFWIALILLIIGIYYVLKWLR
The following text describes a protein:
Function:
High-affinity glutathione transporter which plays a role in scavenging glutathione from the extracellular environment for the maintenance of sulfur homeostasis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MTARNSASIPTSIRKTSENEVSGDETPAGVGNLSTKTASKTSLTFRQSSSDESTSSYSGNHHNINIQHHPNRPFRTNSSSFSPNDYSISESPSKSKKDGVHVSAVQLDNETDSEVESEVEELERELEAIEDSVYPEVRAAVNPTDDVNLPVNTWRTWVLTTIFVIVFAAVNQFFSLRYPALSISFIVAQLILFPLGKLLNLLPNWKIGYGRFSFYLNSSPFNVKEHAAITIAVSLTSSTAYATNILSAQTSFYKQNLSWGYKILIVLTSQMLGYGFAGLTRRWIVYPAAMIWPQTLVSTVLFRTLHGNSGNDIGVLKNNRISANGWTISRYRFFAYVMIGSFVFYWFPGFIFKGLSYFTVLCWIWPKNRVVNQLFGYNSGLGILPLTFDWQQVVYNSNPLASPWWVICNTFGSVVLIFWIVVPILYYKGVWFSNYLPMLSSSTFDHTGVSYNSSRVLNSDYSFNHTKYESYSPLYMPMSYSMSTALNFAAVTAIFTHCALYNGKDIWQRLWKESGKDECIHRKLMRNYKEAPQWWYATLFIVVFGLTIFTVRYYDTQCPVWALIVALLIFIVNFIPQGVLEGITNQHVGLNIITELIGGYILPGKPLANLMIKLYGFIPMRQGLEFSRDLKLAQYMKIPPRILFFVQLFATILGGITQVAVQEWMNYHIPGICTTSQSNGFTCPNGRSIYNASLIWGAIGPAKMFSKGKPYYPLIFFFLIGAVAPFITWGLRKRFPKSWIGKLNAPVLFTGPGNIPPATGINYSSWAIVGFIFNYVIRKRAIHWWRKYNYVLAAAMDSGVAVAGVVIFLCVSYPGGKITWWGNTVYTKTYDWKSVPYRSLGPNETFGYTNW
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi. Involved in plasmid maintenance with SMP2.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFIKKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIMGISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSLINTQDGIESIDEVAFSVGNHHVIDLKGCDLPLLTETIRRLRLNGSITPLTLVTPNSMTSELKKLKRDGTINLIPKRNYLFHLDLDHLDFNDFTTFKPGLTVYSIELL
The following text describes a protein:
Function:
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Miscellaneous:
MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Sequence:
MLPFLSMLVLLVQPLGNLGAEMKSLSQRSVPNTCTLVMCSPTENGLPGRDGRDGREGPRGEKGDPGLPGPMGLSGLQGPTGPVGPKGENGSAGEPGPKGERGLSGPPGLPGIPGPAGKEGPSGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSTGAKGSTGPKGERGAPGVQGAPGNAGAAGPAGPAGPQGAPGSRGPPGLKGDRGVPGDRGIKGESGLPDSAALRQQMEALKGKLQRLEVAFSHYQKAALFPDGRSVGDKIFRTADSEKPFEDAQEMCKQAGGQLASPRSATENAAIQQLITAHNKAAFLSMTDVGTEGKFTYPTGEPLVYSNWAPGEPNNNGGAENCVEIFTNGQWNDKACGEQRLVICEF
The following text describes a protein:
Function:
The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Subcellular Localization:
Mitochondrion.
Sequence:
MSANLLRPVFRSCRVSIPAYSLNSLSRVSSTGFKRFVSTKRYTKEHEWVSLDPKTNVGTIGITDYAQNSLGDVVFVELPEVSATVSSGDLIGAVESVKAASDIFAPVSGTVTEVNTKLADQAGLLNKSPEDEGWLAKIQLSSPQELDNLLSEESYKAHIEGEH
The following text describes a protein:
Function:
Involved in the early biogenesis steps of box H/ACA snoRNP assembly.
Miscellaneous:
MISCELLANEOUS: Present with 7060 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MITPRFSITQDEEFIFLKIFISNIRFSAVGLEIIIQENMIIFHLSPYYLRLRFPHELIDDERSTAQYDSKDECINVKVAKLNKNEYFEDLDLPTKLLARQGDLAGADALTENTDAKKTQKPLIQEVETDGVSNNIKDDVKTIGQMGEGFNWEIEQKMDSSTNNGILKTKYGFDNLYDTVISVSTSNGNDINELDDPEHTDANDRVIERLRKENLKFDPEYYVSEYMTHKYGNEEDLEINGIKELLKFTPSIVKQYLQWYKDSTNPNLVMPIEFTDEEQKQMQDNLPKKSYLVEDIKPLYVTILSVLFSYVFEQIENEGTHTTESAWTMGKLCPQISFLDQQLKQVNELQDGMKEISKVNKDSSLIKIAIITGIRRALSYPLHRNYDLAMKAWTFVYYILRGGKRLVIRALLDIHETFRFHDVYYVYDKVLLDDLTAWFISQGSENVIRSLALEMRKEQESLSKQDIEFECIASFNEQTGEPEWETLNIREMEILAESEYREQQQNPQ
The following text describes a protein:
Function:
Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein. Presynaptic cell membrane.
Domain:
The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.
Sequence:
MARARGSPCPPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGPASSSTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHLNHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane.
Sequence:
MWGGDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVTWGQQPAFLSWVEGRHFRDQGENVAEINRQVGQKLGLSNGEQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAASLEQHLLDQIRIVFPKAIFPIWVDQQTYVFIQIVALIPGASYGRLETDSRLLIQPKTRQAKENTFSKGDNARGKFHNYEGNQKGLTKEPQTKQLQSNTIGITRSQETDSKDTIDASSVPSLWTMIGSIFSFGSEKKQDMSWGLTEINAFKNMQSEVVPLDNIFRVCKSQPPSICNASPTSVFHKHYTIHVFPWDQEYFDVEPSFTVTYGKLAKVLSPKQQQNKTKQSVLSPEKEKQMSEPLDQKQISPDSSQEDDKACVLKVVWNGLEELKNAVKYTKNVEALHLGKVWIPDDLRKRLNIEMHAVVRITPVEITPKIPRSLTLQPRENLPEDVSEEDIKAVFSSWLQQSTTTTLPLIISEEEYIKLEIKDGLKEFSLNTAHSWEKEKEKNIFLLSANLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLNCLGGVNSIGVSSMEHITHSLLGRPLSRQLMSLMAGLRNGALLLTGGKGSGKSTLAKAICKEAFDVLDAHVEIVDCKALRGKRLENLQKTIVAAFSEASWRQPSVVLLDDLDLVAGLPALPEHEHSPEAVQSQRLAHALNDMTKELISMGSLVALIATSQSQHSLHPLLVSAQGIHLFQCVQHIQPPDQEQRCEILHNAIKNKLDCDMNSFTDLDLKRIAKETEGFVARDFIVLVDRAIHSRLSNQSVSTREELVLTTLDFQKALQGFVPASLRNVNLHKPRDLGWDHIGGLREVRQILMDTIQLPAKYPELFANLPIRQRTGVLLYGPPGTGKTLLAGVVARESGMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSASLPLAEDVDLQHVASLTDSFTGADLKALLYNAQLEALHGRLLSCGLQDGGSSSDSDLSLSSMVFLNHSSGSDDSAGDGEYGLDQSLVSLEMSEVLPDESKINMYRLYFGSSYESELGNGTSSDLSSQCLSAPSSITQDFPGAPGKDQFSRPPMFRTASQEGYQELTQEQRDQLRADISIIKSRYRNQIGEDDALNQPGPIRTSLAISQSHLMTALSHTRPSISEDDWKNFAELYENFQNPKKRKNQSGTVFRPGQKVTLA
The following text describes a protein:
Function:
Plays a role in nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSQGAAESEPEAKVLHTKRQYRAVVETVHRLDLIISNKSAYQEVFKPENISLRNKLRELCVKLMFLHPVEYGRKAEEVLWRKVYYEVIQLIKTNKKHIHSRSALECAYRTHLIAGVGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGFKKPVSASSKEMEWARMACHRCLVYLGDLARYQNELAVVDTEKLAERFYYQALTVDPQIGMPFNQLGTLAGSQYYHVEATYCYLRCIQSEVSFEGAYGNLKRLYDKSAKMYHQLKKSETRKLSPSKKRCKDIKRLLVSFLYLQSLMQPKSSSIEAELTSLCQSVLEDFNLCMFYMPTSLNMSSASEDEEEYEGGYSFLPDLIVFRMVGICLMSVHSLKRADSKQYSAAIAFTLALFSHLVNHVNIRLQAELEESPLPAFKNDSPDDNDSKDVSEVIGKDTDPEPEMGENQTRKQQGTKSNSKKSHKYSRLSRLRRRRHARKLDESDLSEGFDSDSSHGSVKGSDISESGSEKSDDEAAFDMETDSDMNSQESRSDLEDMEDDPYERKGKNSLKNPTEEQDAKMAASTKAECQELPVNGPCPASGEASIASNLQAMSTQMFQTKRCFRLAPTFTNVLVKPTVNPSSEAPTPLLNGDVEKQNSVEQEDGSDSEESMLSGKSFRNEKTLQERLEIITSEGLLVTVKIFLDWLRANTDIVIMCAQSSQSLWNRMSVLLNLLPSAPKIQEAGIPLCNEVKKLLMDSELPDINSHLLLPEDAALRNLPPLRQAQRNINFEQERPLLTVLEESVARSCYIRSFGHFLTRLQSNVLQFNTELAIFTSIAEPGQDNILHQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEGTLQQPKSQSAMSPYLVPDTQALCQHLGIIRQLATSGRFILIIPRAVIDGLDFLKKENAGARDGIRYLEAEFKKGNRYIRCQRETGKSYEKNKLKRQDTDAWHLYKILDSCKQLTVSQGNNDEDTAGMVTIITGFHLNDPHSFSPAMQTALQTASSSNIEIKNVLEFYKQWKEMG
The following text describes a protein:
Function:
Has a role in chromosome segregation and cell morphology upstream of the ras1-scd1 pathway. Promotes the exchange of ras1-bound GDP by GTP leading to its activation.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRPNLDRLRLKSRQGFETSVSKPSTPSYSTYSLSPTFSDKSVLSPSTMSDSYALSSTYTAGSSYQNGESDYFGSLPTPSSDKSSTSPFPYLKGSFDDRFSSTHSLTRQPSPRSPLTPLKGNTRASPEIRYVSDFTPPSSPFEDMQASVHSLPLSGCSIGPVRTNHSSSLSNSSNSLLQTESSLRPNSSFVNSPFFPLPSSDDLFLNDRVINLFLFYEKFSYLFTHLLSAIKSRDALSIPSLVLSLQEELFNLCQQTGTFYLLQHNLLQNFEFENPIKLHFDKIIPYFSRLTVLTFSNRAFIFPDHTFPRLQQSAEDFLYHLQFFFTLCANNSLYLSRFCYYPSFVPNTPFGGKWTNNGLSAVSSAYRTRLLEPCLPELDKCVWFLLKNCDEFIENFSDFADEEYVFEICSTITSHSEQIFNKLESWDMSIYFDKDLSECEQATNFAVQSYFVTKQRCYDLLTDLVCSSQDLMMEHSNDFSTMPTMIASIAVAFQTLFENVCDFLKVRAALVDEMQELATKEFENKFSNANTAKDDEPARQTNKGTTRISRSSDFTAVSEMSKDTLTLGRNSLQSILMLDNLLTNKVVQSDNNVKGGTLPALVHYLVQNVHLNKDFRHSFLLTYKTFTTPQELFTLLVILFHELPPPGLDATAYSSWEKGDNFVTKKNVCTVMNLWVQKYFFEDLKARNTLYLISEMRTFLRDHVVPSFHIGSVILSEIDNLWTEEPPDSLTQRLLSSPMATFISLNVYAYTPEEFASQMTLLEFDYLKQIPSREWIFRSWVSRDSRSAVRNYINFSNCFTYWIINCILEKKNTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAPIYRLHAAYKLVKAEDIICLSGLREIVETKKNFSTYRALLRKAELPCVPFLGVILSDLTFIDEGNPDVLDSSPHLLSFNKRHRLADVVADVCRFQSSSYEMQSNTDLQSYILHRCRFVNQDLSYLFDKSLSLEPRSS
The following text describes a protein:
Function:
Probable transporter whose substrate is unknown. Is not involved in aerobic D-malate transport.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVLLAMGLVIYLATSKYGNIRLGEGKPEYSTLSWLFMFICAGLGSSTLYWGVAEWAYYYQTPGLNIAPRSQQALEFSVPYSFFHWGISAWATYTLASLIMAYHFHVRKNKGLSLSGIIAAITGVRPQGPWGKLVDLMFLIATVGALTISLVVTAATFTRGLSALTGLPDNFTVQAFVILLSGGIFCLSSWIGINNGLQRLSKMVGWGAFLLPLLVLIVGPTEFITNSIINAIGLTTQNFLQMSLFTDPLGDGSFTRNWTVFYWLWWISYTPGVAMFVTRVSRGRKIKEVIWGLILGSTVGCWFFFGVMESYAIHQFINGVINVPQVLETLGGETAVQQVLMSLPAGKLFLAAYLGVMIIFLASHMDAVAYTMAATSTRNLQEGDDPDRGLRLFWCVVITLIPLSILFTGASLETMKTTVVLTALPFLVILLVKVGGFIRWLKQDYADIPAHQVEHYLPQTPVEALEKTPVLPAGTVFKGDN
The following text describes a protein:
Function:
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein. Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA). The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
Miscellaneous:
MISCELLANEOUS: Hepadnaviral virions contain probably just one P protein molecule per particle.
Domain:
Terminal protein domain (TP) is hepadnavirus-specific. Spacer domain is highly variable and separates the TP and RT domains. Polymerase/reverse-transcriptase domain (RT) and ribonuclease H domain (RH) are similar to retrovirus reverse transcriptase/RNase H; The polymerase/reverse transcriptase (RT) and ribonuclease H (RH) domains are structured in five subdomains: finger, palm, thumb, connection and RNase H. Within the palm subdomain, the 'primer grip' region is thought to be involved in the positioning of the primer terminus for accommodating the incoming nucleotide. The RH domain stabilizes the association of RT with primer-template.
Sequence:
MPLSYQHFRKLLLLDDEAGPLEEELPRLADEGLNRRVAEDLNLGNLNVSIPWTHKVGNFTGLYSSTVPVFNPDWKTPSFPHIHLQEDIINRCQQYVGPLTVNEKRRLKLIMPARFYPNLTKYLPLDKGIKPYYPEYAVNHYFKTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELQHGRLVFQTSTRHGDESFCSQSSGILSRSPVGPCVRSQLKQSRLGLQPQQGSLARGKSGRSGSIWSRVHPTTRRPFGVEPSGSGHIDNTASSTSSCLHQSAVRKTAYSHLSTSKRQSSSGHAVELHNIPPSSARSQSEGPIFSCWWLQFRNSKPCSDYCLTHIVNLLEDWGPCTEHGEHNIRIPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGSTHVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLLVGSSGLPRYVARLSSTSRNINYQHGTMQNLHDSCSRNLYVSLLLLYKTFGRKLHLYSHPIILGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLFTSITNFLLSLGIHLNPNKTKRWGYSLNFMGYVIGSWGTLPQEHIVQKLKQCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQSKQAFTFSPTYKAFLCKQYLNLYPVARQRSGLCQVFADATPTGWGLAIGHRRMRGTFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLYRPLLHLPFRPTTGRTSLYAVSPSVPSHLPDRVHFASPLHVAWRPP