lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MFTKIPLTAAILAGGKSSRMKRQKCLLSFDNEKIIDMIVTKLKDIFEELFIVTNFPELYFYTGITLLGDIYPFRGPMSGIHVAIKNSKHDIFAFACDMPFVKGEVICALSEKHIKEANTATVPSYNGKIYPLPGIYSRKLLDELEKLLLEDKLSMTKFLNDIGAEIVEVANLDKEGLSFININTEEDLENLKKGGIKCLD
The following text describes a protein:
Function:
Acts as a negative regulator in the ethylene response pathway. Phosphorylates the cytosolic C-terminal domain of EIN2, preventing the signaling in the absence of ethylene. Interacts with C24:1-ceramide upon hypoxic conditions (e.g. submergences) to in turn regulate EIN2 endoplasmic reticulum (ER)-to-nucleus translocation and EIN3 stabilization.
Sequence:
MEMPGRRSNYTLLSQFSDDQVSVSVTGAPPPHYDSLSSENRSNHNSGNTGKAKAERGGFDWDPSGGGGGDHRLNNQPNRVGNNMYASSLGLQRQSSGSSFGESSLSGDYYMPTLSAAANEIESVGFPQDDGFRLGFGGGGGDLRIQMAADSAGGSSSGKSWAQQTEESYQLQLALALRLSSEATCADDPNFLDPVPDESALRTSPSSAETVSHRFWVNGCLSYYDKVPDGFYMMNGLDPYIWTLCIDLHESGRIPSIESLRAVDSGVDSSLEAIIVDRRSDPAFKELHNRVHDISCSCITTKEVVDQLAKLICNRMGGPVIMGEDELVPMWKECIDGLKEIFKVVVPIGSLSVGLCRHRALLFKVLADIIDLPCRIAKGCKYCNRDDAASCLVRFGLDREYLVDLVGKPGHLWEPDSLLNGPSSISISSPLRFPRPKPVEPAVDFRLLAKQYFSDSQSLNLVFDPASDDMGFSMFHRQYDNPGGENDALAENGGGSLPPSANMPPQNMMRASNQIEAAPMNAPPISQPVPNRANRELGLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPNRSDL
The following text describes a protein:
Function:
Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV.
Subcellular Localization:
Endoplasmic reticulum lumen. Note=Colocalized with PLOD3 and mannose binding lectin.
Sequence:
MAALPRGSRGLPLLPLLLLLPPLGGPRGADGYFPEERWSPESPLQAPRVLIALLARNAAPALPATLGALEQLRHPRERTALWVATDHNTDNTSAILREWLVAVKGLYHSVEWRPAEEPSSYPDEEGPKHWSDSRYEHVMKLRQAALKSARDMWADYILFMDIDNLITNPDTLSLLIAENKTVVAPMLDSRAAYSNFWCGMTSQGYYKRTPAYIPIRKRDRRGCFAVPMVHSTFLIDLRKAASRNLAFYPTHPDYTWSFDDIIVFAFSCKQAEVQMYVCNKEVYGFLPVPLRAHSSLQDEAESFMHVQLEVMVKHPPVQLSRFISAPRKTSDKMGFDEVFMINLKRRRDRRERMLRALHEQEIDCQLVEAVDGKAMNTSQVEAMGIQMLPGYRDPYHGRPLTKGELGCFLSHYNIWKEVVDRGLQKSLVFEDDLRFEIFFKRRLMNLMRDVEREGLDWDLIYVGRKRMQVEHPEKAVPHVRNLVEADYSYWTLAYVISLQGAQKLLAAKPLAKMLPVDEFLPVMFDKHPMSEYKSHFSPRNLRAFSVEPLLIYPTHYTGDDGYVSDTETSVVWNNEQVKTDWDRAKSQKMREQQALSREAKNSDVLQSPLDSTARDEL
The following text describes a protein:
Function:
Transcriptional factor. Plays a critical role in neuronal morphogenesis. Represses the corneal epithelium differentiation (By similarity). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The acidic N-terminal part may favor interaction with the basic domain of transcription factors; The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF7, the motif is inactive.
Sequence:
MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKASLSSVKVGGVAAAAAVTPAGAVKSGQSDSEQGGGGADTCPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRTIAIVAGGDTSEFHVSLRSAQGIYSFIDKEKYTLYIVEMQGTRWEVQLPDGAKAPVDRNDFSFMLGTEKIRFDFAYITIHGTPGEDGRLQGYFDMMHIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQSVSDEDVMEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFEEAQEVLVEAFMEGTELTCGCYKTKDKTVIFPPTEVVTHNEFFDYDAKYNGQVDEITPARISDELTNRVQMLTSAIYDILGCSGIIRVDYIVTAGEKINLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDIIENKF
The following text describes a protein:
Function:
Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAPLSRKWLPVVGAVALALTFAQSPGQVSPDTKLDLTANPLRFLARATNLWNSDLPFGQAQNQAYGYLFPHGTFFVIGHLLGVPGWVTQRLWWAVLLTVGFWGLLRVAEALGVGGPSSRVVGAVAFALSPRVLTTLGSISSETLPMMLAPWVLLPTILALRGTSGRSVRALAAQAGLAVALMGAVNAIATLAGCLPAVIWWACHRPNRLWWRYTAWWLLAMALATLWWVMALTQLHGVSPPFLDFIESSGVTTQWSSLVEVLRGTDSWTPFVAPNATAGAPLVTGSAAILGTCLVAAAGLAGLTSPAMPARGRLVTMLLVGVVLLAVGHRGGLASPVAHPVQAFLDAAGTPLRNVHKVGPVIRLPLVLGLAQLLSRVPLPGSAPRPAWLRAFAHPERDKRVAVAVVALTALMVSTSLAWTGRVAPPGTFGALPQYWQEAADWLRTHHAATPTPGRVLVVPGAPFATQVWGTSHDEPLQVLGDGPWGVRDSIPLTPPQTIRALDSVQRLFAAGRPSAGLADTLARQGISYVLVRNDLDPETSRSARPILLHRSIAGSPGLAKLAEFGAPVGPDPLAGFVNDSGLRPRYPAIEIYRVSAPANPGAPYFAATDQLARVDGGPEVLLRLDERRRLQGQPPLGPVLMTADARAAGLPVPQVAVTDTPVARETDYGRVDHHSSAIRAPGDARHTYNRVPDYPVPGAEPVVGGWTGGRITVSSSSADATAMPDVAPASAPAAAVDGDPATAWVSNALQAAVGQWLQVDFDRPVTNAVVTLTPSATAVGAQVRRILIETVNGSTTLRFDEAGKPLTAALPYGETPWVRFTAAATDDGSAGVQFGITDLAITQYDASGFAHPVQLRHTVLVPGPPPGSAIAGWDLGSELLGRPGCAPGPDGVRCAASMALAPEEPANLSRTLTVPRPVSVTPMVWVRPRQGPKLADLIAAPSTTRASGDSDLVDILGSAYAAADGDPATAWTAPQRVVQHKTPPTLTLTLPRPTVVTGLRLAASRSMLPAHPTVVAINLGDGPQVRQLQVGELTTLWLHPRVTDTVSVSLLDWDDVIDRNALGFDQLKPPGLAEVVVLSAGGAPIAPADAARNRARALTVDCDHGPVVAVAGRFVHTSIRTTVGALLDGEPVAALPCEREPIALPAGQQELLISPGAAFVVDGAQLSTPGAGLSSATVTSAETGAWGPTHREVRVPESATSRVLVVPESINSGWVARTSTGARLTPIAVNGWQQAWVVPAGNPGTITLTFAPNSLYRASLAIGLALLPLLALLAFWRTGRRQLADRPTPPWRPGAWAAAGVLAAGAVIASIAGVMVMGTALGVRYALRRRERLRDRVTVGLAAGGLILAGAALSRHPWRSVDGYAGNWASVQLLALISVSVVAASVVATSESRGQDRMQ
The following text describes a protein:
Function:
Putative guanine nucleotide-exchange factor (GEF) involved in the formation or budding of transport vesicles from the ER. Positive regulator of SAR1 probably through inhibition of the GTPase activation by SEC23.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=In the process of transport, SED4 itself may migrate to the Golgi apparatus and function in subsequent transport events.
Sequence:
MSGNSANYDVGYPIYGAKFINEGTLLVAGGGGQFNSSFPNKITALKVNFQKKKHIRRFREITLDSIDDAPTSLDCNNNLILVGCNELFNDSSMENVNHHLRKFVFEQEHLKFVASIDFNRTTDPSVFTKFVYINQRATVAAIASSEVPTVIRIIDPRNLTENYEIETGREVNDLHFAPNGILLSYITSNSLEVASVRDGNFVARKTDFDKNLVLSNIRFLNDNTLLVAASLSNSDGVSLLKLGVSSKGVKILKTASFMFDLNGITSMDVSPNKKFVALSSNDNLVAIVSVEKLKLVQLVPRVHESTITKVTFSPDSRYLASTSMGNTINVLKLSGTSSSILRNIWKFFLNFVLLVVLAGAIQLGYKHNVHGFIYKHAHDIYKSKFKENTTIDQGSSSYFTINDDYRGITESADIISATDVASDIETEFSSFDTSTMRTTTEDEQKFVWISSSADSQFTSADIPTSASSSSSSSSSSFYEESVTNEPIVSSPTSEITKPLASPTEPNIVEKPSLPLNSESIDLLSSSSNSITEYPEPTPDLEEKLSSLIVEQSESEITTDRESVSKLLSTESPSLSHMPSSSSSSLSLSSSLTTSPTTALSTSTATAVTTTQTNPTNDAANTSFLDNSKPASTREIYKTKIITEVITKIEYRNIPASDSNAEAEQYVTTSSSMLLTPTDTMVSSPVSEIDPIASELERMVETPTHSISIASEFDSVASNLIPNEEILSTSASQDSISSHPSTFSDSSITSGFQSIEVSTVTSSVLASESIPSISDSTFSKFHSISEPVSSAIVETATSSFSKTETKTSRVIAFSTEDSERSSALIDNSEYTSVLADNLEPTSVLADNSEPTSVLADSSEPTSVFTDAVQSPKTSVGQSSLSESTNIEGTSMASMIFSSSGASIGALSDIGKGTLSVESASSTVAQPMPGVTTTAPSFVSSPHKISASSIDASGFVQKEIMIEVQSSKDSSEAFGVRHKISENVNTPVSRMLTTEMQASGTVDVTEDVSLSSEVISALNVEITSLPNPVAPPQTIAAPLNNNSNTNIVNDDNAVAGTVNYAGLHDEL
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the ATM2 gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels. PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis. Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline. Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ. Finally paxilline can be mono- and di-prenylated by paxD. PaxP can also utilized beta-paxitriol and alpha-PC-M6 as substrates converting them to paxilline.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MDLSDFHISTPLRYFHEEASLLWKLGVFAVLVYFLLPKPTYKTNVKVPTVKYMGPWMPEILSRIFFNSHAPTVIYKGYEKFKTSAFKVVKPDGDLVVLSTRYAEELRQMPSTTLNALEATFTDHVGGYTTILTDSHLHTETIQKKLTPAIGRLIPRMISELDHAFEVEFPTCDDQFASINPYTVFLRLVARVGARIFIGDELCREEKWLQASIDYTKNIFLTIALMRPMPGFLHPIVGRILPSSRSLKDQLSYIQQDLLGPVIKERRRLEASSDSEYKKPDDFLQWMMDLAQNENESHPDNLSHRLLGITSMAVVHTSAMSMTHILYDLLTMPDLIEPLRDEIRNEIKDWNKATQADLSRLIIMDSFLKESQRLNPPGDLSFHRVVKKDLTLSDGLFLPKGTHICMAAGPISKDPDVVSDPDTFDAFRFVKQRTATSGFVSTGPNNMHFGLGRYACPGRFFAAFVIKLILSRFLMDYDFKFETEHKERPKNLLIGDKIVPNVATPILIKRRATKA
The following text describes a protein:
Function:
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Miscellaneous:
MISCELLANEOUS: Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MCDMGGLDNLIANTAYLQARKNSEGDVKELQKRRKSLSLPSTDVSRKEIKETITLDYQSICVEQPIGQRLFRDFLGTVSEYKLAEEFLEEVKEWELEEGSAKEQLMEKLVSRRFKEPAEGSLNFLGKDLSSRIQQAQSKDMPELILLAKDAGNAFLMDAPFQDFQNSPFYDRFLQWKAFERQPINQKYFYEFRILGKGGFGEVCAIQVKNTGQMYACKKLDKKRLKKKNGEKMALLEKEILEKVHSPFIVSLAYAYETKTHLCLVMSLMNGGDLKFHIYNIGEKGIEIKRVIFYSAQICCGILHLHSLKILYRDMKPENVLLDDNGNCRLSDLGLAVKVKEGKPITQRAGTNGYMAPEILTDVDYSYPVDWFAMGCSIYEMIAGHTPFRDPKEKTSKEEVKRKTIEDEVVFQHPVFTEEAKDICRLFLAKKPQNRLGSRTNDDDPRKHAFFKSINFQRLEAGMVDPPFVPDPSVVYAKDISDIADFSEVKGIEFDDKDSKFFKRFATGAIPISWQKEIIDTGLFDELNDPSREATGGGGNSGEKSGVCSIL
The following text describes a protein:
Function:
Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (Probable). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate. Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (Probable).
Subcellular Localization:
Cytoplasm.
Sequence:
MQKDASSSGFLPSFQHFATQAIHVGPEPEQWSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAHP
The following text describes a protein:
Function:
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA).
Sequence:
MPSKKALVRRPSPRLAEGLVTHVEREKVDHGLALEQWDAYVEALGAHGWETLEVDPADDCPDSVFVEDAVVVFRNVALITRPGAESRRAETAGVEEAVARLGCSVNWVWEPGTLDGGDVLKIGDTIYVGRGGRTNAAGVQQLRAAFEPLGARVVAVPVSKVLHLKSAVTALPDGTVIGHIPLTDVPSLFPRFLPVPEESGAHVVLLGGSRLLMAASAPKTAELLADLGHEPVLVDIGEFEKLEGCVTCLSVRLRELYD
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVSNDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPTGAEQIRTGEIVDVAFLAQHG
The following text describes a protein:
Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein.
Sequence:
MTSLFKKKTVDDVIKEQNKELRGTQRQIARDRTALEKQEKQLEMEIKKMAKTGNRDACKVLAKQLVQVRKQKTRTYAVSSKVTSMSTQTKLMNSQMKMAGAMATTTKTMQAVNKKMDPKKTMQTLQNFQKETAKMDMTEEMMNDTLDEIFEDSGDEEESQDIVNQVLDEIGIEISGKMAHAPSAARKTPSAATAKADGISDEDIERQLKALGVD
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MEPQRNSQMLQNLYAVGPEARFQSMSAPLVVHDGVWTAYDRNQIPDVDESVSNLFSSLNISSPSNFHCRNIIPPVGYDGGVTGAGTGSPIGAGEGSGRHPFRTGIRSSYYTLGGQTSALTVDPQRNYYPLWRNREVGCSVGFDQMFDFDQSFDLLPKEHIYNPHNVSRSVNVSVLCLKELRGKVYALAKDQNGCRLLQAKFENPSDEEVEFVLYEVLEYISELMKDQFGNYLIQKLITVCNDDHKLRMLLSLTDVPVEMVLVCMNPHGTRAMQKLLENLTDPYHIALAMAALRPGAARLASDPNGHHVIQYCLIHFPSDVIEPILNEIADKCYEVATDRSGCCVLQACMEHSHGKVRNRLVAEILGNAVVLAEDPYGNYVLQHMVGLKVPEFTARLVRQLQGNFASLSCNKYASNVVEKCLNESSEDISRQIVMELITCSNPALLLIDPYANFVIQSALTVSTGHVYNYLLELISDNMSSMRTNLYGKKILSWFEKRRILAI
The following text describes a protein:
Function:
Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLRKH
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADIFKRTYNKLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDPLSANLVNIDGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSCAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGAPELAAKLRMKATVQEVEDFYMNIIRDTVDYRVKNNVKRHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSKGGIHLKVTRV
The following text describes a protein:
Function:
Probable chloroplast-localized Mn(2+)/H(+) and/or Ca(2+)/H(+) antiporter regulating Ca(2+), Mn(2+) and pH homeostasis.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MKLTSLSKNANSTATAVTVSSIQKLPFLSLSETLPCPKSSRKPTFLPLRCRRRPKLDLLWGKFRVRASDAGVGSGSYSGGEEDGSQSSSLDQSPATSSESLKPRGPFPYSLSIALVLLSCGLVFSLITFVKGGPSSVLAAVAKSGFTAAFSLIFVSEIGDKTFFIAALLAMQYEKTLVLLGSMGALSLMTILSVVIGKIFQSVPAQFQTTLPIGEYAAIALLMFFGLKSIKDAWDLPPVEAKNGEETGIELGEYSEAEELVKEKASKKLTNPLEILWKSFSLVFFAEWGDRSMLATVALGAAQSPLGVASGAIAGHLVATVLAIMGGAFLANYISEKLVGYVGGALFLVFAAATFFGVF
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAAVEQLKELGEKLQAVAPAPADELAKLLEKAVECLHGIEQSPVSSVMEAIQPSLKAVTREELLKHEDDNVKVLLATCFCEITRITAPDAPYNDDILRDIFYLIVGTFGGLNDVNSQSFGRKVAILETVARYRACVVMLDLECDDLITNMFQTFLVVVSESHEEYIVKSMQTIMTLIIDESEDVHESLLRVLLSALGQKKTGAAMSARKLACSVIEHSATKLEPYLKKFLMSSWAGNVSSSNDQIDHQGVVFDLYQCAPKVLKVIVPYITGELLADEVDNRSKSVELLGEIFSLPGSPIVECFETLFTEFLKRLTDRVVEIRISVVEYLKRCLISNPSRAEAPEIIKALCDRLLDYEENVRKGVVAALCDVATHSPDAIPIDTIKVVAERVRDKSLAVKCYTMERLADIYKLYCQRGFDSSTNSDDFEWIPGKILRCLYDKDFRPESINSILCGSLFPPEFPMKGRVKHWVTAATYFDKVEMKALEQILLQKQRLQQEMMKYISLRQLSQEDAPDLQKRIIGCFRNISRLFSDSAKCEENLNMLHQLKDADIWKIFTSLLNCSTTFEKAWSLRADLLKIFGEKHVLYNFVGALAMGCSYLLVNKEYAKEILSEASEQKTSGNTKLISSCMNLLTAISSFFPSLLSGLEEDIVELLKEDNEVLKEGIAHVLSKAGGTIREQLASTSSLDLLLERLCLEGTRRQAKYSVHALAAITKDDGLMSLSVLYKRLVDLLEEKKVNIPSILQSLGCIAQIAMPIFETRKEEIISFITKKILECNDDMVRNSSNKSEWGDSTENCLLKIYGIKTLVKSYLPCKDAHAQPGIEKLIDILKNILTYGDVSPNMVSSAADKAHLRLAAAKAVLRLSKQWDHKVPVDVFYLTLRISQDDFPQVRKLFLCKVLQYIKERALDAKYACTFMFGVNDYHAPPYEEFKYNLTEVVQICQQVKMRQLSVQADMDLLTAYPEYIISFLVHALAHDPSSPEIEEHENVNAFGPIYWRLYLILSILLGEEGLQHSVPGMKKDSFTTIISIFKSIKSSQDVVDGSKTKTVCAICDLGTLIAKRLCQDQTSLSEAQTVPLPAQLYTPLHDNQNENSVENNEQIWLGCEKVLAHFEAVRTANMDKVESPKHKMLIDVTDEFGNEVPLGKIVKLLKSRGERKIGEKQKAPSSSSVNAENDDVLGLVREINLNNQEDLEESHKDKSEKRHTNAKDSNQKPLDFSSPKRKRSISKSRPHSAKGSKSSDERLLHTPNSERTNISLETKMKEKDRDDSTDTELLVSPSTRTPVSKQNKGAKKSNINILSSVPKKSADADSTKRTVEPRSLNGSLKRQKSKPISGLLKCSTQDSSSTDLVGHRIKVWWPLDKRFYEGAVQSYDSSKKKHRVLYDDGDVEVLNLAKEKWILIESNDSSVKKQKKDHLGTNPGRALEITSSSKSPPSQTKSKKRSLPSKKKGQPTNKRRKTAGRNNSVEEGSGAGGNDSDSSSSLARSDVDKDVNSDGHMEEVVVSSAEKENARKDSKDVKIKEKSAKDFKGLETKEKARKDSKGLETKKKVGNEMKEKAGKDSKDMEMKEKIGKESKDVEMKEKAAKKSKDAEVKEKPGKDSKDVKMKEKVGKESKDAHVKEKAGKDSKDLEMQGKAGKESKVVEKLDDHTLSNKEESDSETLSVWKKRTAKAT
The following text describes a protein:
Function:
Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export.
Subcellular Localization:
Nucleus.
Sequence:
MQSEMAIDTVATAEKSPLELLQQTKASVEAIIAKMLSIKQQGTPKSENRELLTQMFLNFINLRQANRSILIEEEKVRTETEIAKSPVDFTTLELHNLMYEKSHYLKANKASRDFKSRYPNIDLISEQDFFSDAPEAIKSQTLSNDSSHDLMLKRLNFELHQRKELCKLRVRLEQQKKSLLESNAERNKFLSSLPVHLKSLKKASLPVQSQLSLQNQKKLKYHNLAELLPPPLYVIYSQFMALKEAFEENIDVEVSGSLKDAQTYARQQAEQNSESLRLEVGVDEERQRKRLKKVGSDEGGVYQVHPLKVVLHVYDDEITDPKSHELVMLKFEYLLKLNVVCVGIEESEDGLEKNILCNLFPDDSGLEPPHQSAKLILGNDHVFDKSRTSRPYKWAQHLAGIETLPEMSPFFTDKDIQYSDTAKGYASASDHRNVQTVLQRIRSQKKTKLTLV
The following text describes a protein:
Function:
Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (By similarity). Plays an essential role in early embryonic development.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MPGSALLSLQQELRRGFEALKAAKDTFDGGHAECQELVSSLGNLAPQLKALKQVQISETPLSGFPCLQQRLHYKLSLAVDALLAKLAEKMAALQKVWDAFAQQVFTVVQLYEKNTDALDISVCVSRSAVCPSVSDMLEWLQDADRYYRLQLMQSRLLLQTLTPTDLTSMETAPNRWRSVRSARQEERIADALCQVSIFLETE
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
Subcellular Localization:
Chromosome, centromere, kinetochore.
Sequence:
MSDLANVYQLFRSKFEDNDFQYYYPPSYIRSLTECDDKIIFAFRKVQNHILSSEMDAVRPKQSPNSNGSASLDLTGSPLRDVSFEQFEEMNLSKEYHESSVQNLWTIDEETYAPLSTEKARSLLQAFISLECRIGRGSIWVLCCGTDSEQKVLLQLSVNAASNNQRHFTRGVVRFSGVQPSNSITLGQLIDIHRQRAGEGMKFSPKIQIQQWCKLHAQITLRLSWNAMGEGSTFAVERNARVRLSQEFPVNNGAFSRSSPAEYFWQQLQRLAMMRERIMDIRANRESGYARNDVCGEAEMDLEYIKQKVNNILSSFLEVEPVTYNSSTIIDMVSLVQKRKLTDVMERLYDALTLCSSYEDLKAAIDYIFHLSTHSNIVNVPTNGTRFSQLILAMIQDRLAIPLLTGSEPYELLLECGFSKLMNDYRTIFTEAGIYELEFEKLFQPQVTNTRKSRYATGNGPQLDAHHGAPSKRSATQLFQSAAGEERVREKSILLSNFDEDEVKLRLNRLAQVHLLLEHLLLLESAVNVPSIYGRVCELYLGRAPYSYGEVYNRRTDLLEFELDEFMLLRKADHVLPCARRVTMSSANMLQKLETVFYQNVKPILPGRFYPQFECKELDSKHEFWCYEYDRIESL
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Binds to the 18S rRNA but non-specifically.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEVAPEEIIENADGSRSIITYKIEDGVKYKITQKVKEVKVLEKVHKSVAERKNWHKYGSEKGSPAGPSAVTARLGEEVELRLSRNWKQAEEERIQKEKASLTKTGLQCRLCGNDHMTMNCPFKTILSELSALEDPATNEGGVEAASEEKAGQVGGAGSIPGQYVPPSRRAGARDPSSDAYRDSRERDDMCTLKIMQVNENADENSLREELLFPFAPIPRVSVVRNKETGKSRGLAFVTFSSEEVAEQALRFLDGRGYMNLILRVEWSKPKVKE