lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSADALKDVIGGGKDLYALLEVSISSPEELEAVDAAQLRAQFRRLALRYHPDKRRDDTQQNDKFVSVQKAYDILSNSSLRATYNRWLSCRLFGDPERRRLVRELHQREQLQVRQKEPMDKDIQNIQSYGQLLRKMRHLRIPYGDWRPNTSISRDSTLVETCTLRLLLRQNSTTNSKSSMLQLFQRAKLHIVDLYFSSRNVDTENDLVLYAVMPDVDTMLDLLNNWAVKPPLSEHILQVQPRVHTDYFHFKTDISLDKTITEAIDADNQYMSSF
The following text describes a protein:
Function:
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Miscellaneous:
MISCELLANEOUS: Overexpression of FLZ4/IRM1 rendered plants shorter which creates mechanical resistance to M.persicae aphid attack.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles from the cytoplasm to the nucleus when associated with KIN10.
Sequence:
MVLGKRHGSLIKRTTSMKMITLDTPTIYDASQPSDHLTFHQHPHNPMVVMASNYDDFLKTCSLCNRSLCHHRDIYMYRGNNAFCSLECREKQIKLDEKKAKTGFVTSKKPIRI
The following text describes a protein:
Function:
May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSEHAAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPGGLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGADALNDSQDFPFPETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSPPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAPSTPDSSRPDPGVPLEDAPAPAGS
The following text describes a protein:
Function:
Probable insulin-like peptide which negatively regulates synapse development at the neuromuscular junctions. Probably acts as a daf-2/InsR agonist ligand to prevent dauer formation under optimal environmental conditions.
Subcellular Localization:
Secreted.
Sequence:
MFSFFTYFLLSALLLSASCRQPSMDTSKADRILREIEMETELENQLSRARRVPAGEVRACGRRLLLFVWSTCGEPCTPQEDMDIATVCCTTQCTPSYIKQACCPEK
The following text describes a protein:
Function:
Homophilic binding protein that enables kin discrimination in heterogeneous yeast populations by mediating homotypic cell-cell interactions during flocculation, a reversible and asexual process in which cells adhere to form aggregates (flocs).
Domain:
The Flo11 domain contains aromatic residues that form two hydrophobic bands on the surface of the protein that confer homophilic binding. The hydrophobic bands are lined by stretches of acidic residues that may sensitise the protein to environmental pH (By similarity).
Sequence:
MVSLRSIFTSSILAAGLTRAHGSSGKTCPTSEVSPACYANQWETTFPPSDIKITGATWVQDNIYDVTLSYEAESLELENLTELKIIGLNSPTGGTKLVWSLNSKVYDIDNPAKWTTTLRVYTKSSADDCYVEMYPFQIQVDWCEAGASTDGCSAWKWPKSYDYDIGCDNMQDGVSRKHHPVYKWPKKCSSDCGVEPTTSDEPEEPTTSEEPVEPTSSDEEPTTSEEPTTSEEPEEPTTSDEPEEPTTSEEPEEPTTSEEPEEPTTSEEPTTSEEPEEPTSSDEEPTTSDEPEEPTTSDEPEEPTTSEEPTTSEEPEEPTTSSEEPTPSEEPEGPTCPTSEVSPACYADQWETTFPPSDIKITGATWVEDNIYDVTLSYEAESLELENLTELKIIGLNSPTGGTKVVWSLNSGIYDIDNPAKWTTTLRVYTKSSADDCYVEMYPFQIQVDWCEAGASTDGCSAWKWPKSYDYDIGCDNMQDGVSRKHHPVYKWPKKCSSNCGVEPTTSDEPEEPTTSEEPEEPTTSEEPEEPTSSDEEPTTSEEPEEPTTSDEPEEPTTSEEPEEPTTSEEPEEPTTSEEPEEPTTSDEEPGTTEEPLVPTTKTETDVSTTLLTVTDCGTKTCTKSLVITGVTKETVTTHGKTTVITTYCPLPTETVTPTPVTVTSTIYADESVTKTTVYTTGAVEKTVTVGGSSTVVVVHTPLTTAVVQSQSTDEIKTVVTARPSTTTIVRDVCYNSVCSVATIVTGVTEKTITFSTGSITVVPTYVPLVESEEHQRTASTSETRATSVVVPTVVGQSSSASATSSIFPSVTIHEGVANTVKNSMISGAVALLFNALFL
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes at the barrier septum.
Sequence:
MFDQLEFYPAVNYEDNETQNDIKLPEVAKLENIETVHSISKERRDSLTEILNDSSSLPARPFSLPNPNNSTVEKQSLFPFEEKMNPIWIISRPTFSIEQDAEKKINELQTFTNIIDQILGQTNNIESTLLSMKEKFESSEKKLSEFSEMCENLSTDEMRFSEIADGIRKGLTIFAPLKELTRVFRHPPPDFAGKVSFKEHITQLNTCIMFLEENLDFQESPHYLGQYKKLLSQAMDIFKPYFIRIIKQTTDQVLKDSKKMDVHKQLHSSLFYARFSAVGHNLCPTITELCKLCSKESLDAFLPAFYDVYFQCRTRLLKPVLDYHLKSFFMEKSISSYIQKSLALLQLTFFDENKLFREILIMDDFRFMHYWNNLCQSFFENSRSLILHEKNLTELCEVCSYIQSFQNAILEGEREDVDKKVVEFLNPLVLELQERLLFVVQTAIETDIQRYSPTEEDLNPIADDKSLLFDLEKLRLNNDEEKLDPDVPQKLAMAQGWYPVVQKSLIILSKIYRLVNSQVFDEIALELVHSCIRSLVDAYRYFSRNNDKQLARLFLIKNFLVLKDQLNSFDIHYACIEAGVDLRKVWDSVREWRSNLRGVLQLVYETFPKFITNAVDTRQELNQQLRVAVNGYIETAVIHYTECLSIGNLESITEFQNRIQKFPELRQQISLYLSETWIIELFLQAIREEVVSKFQNFYESIVANEDITGSDHNKSGTTSLKHLNEYVEDIYSVMS
The following text describes a protein:
Function:
LRR receptor kinase involved in the regulation of root growth and root nodule organogenesis. Involved in long distance nodulation signaling events (Probable). Involved in the autoregulation of nodulation (AON), a long distance systemic signaling from root to shoot and back again, which allows legumes to limit the number of root nodules formed based on available nitrogen and previous rhizobial colonization (Probable). Acts from shoot to root to control AON. Interacts with CLE12 and CLE13 signaling to control nodule numbers. Required for the modulation of shoot-to-root auxin transport in response to altered nitrogen tissue concentrations and in the absence of rhizobia. Shoot-to-root auxin transport influences lateral root density and length. Involved in the regulation of root colonization by arbuscular mycorrhizal (AM) fungi. Interacts with CLE33 and CL53 signaling to repress strigolactone biosynthetic genes and strigolactone content in the roots, and consequently reduces the promotion of further colonization by AM fungi.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKNITCYLLLLCMLFTTCYSLNNDLDALLKLKKSMKGEKAKDDALKDWKFSTSASAHCSFSGVKCDEDQRVIALNVTQVPLFGHLSKEIGELNMLESLTITMDNLTGELPTELSKLTSLRILNISHNLFSGNFPGNITFGMKKLEALDAYDNNFEGPLPEEIVSLMKLKYLSFAGNFFSGTIPESYSEFQKLEILRLNYNSLTGKIPKSLSKLKMLKELQLGYENAYSGGIPPELGSIKSLRYLEISNANLTGEIPPSLGNLENLDSLFLQMNNLTGTIPPELSSMRSLMSLDLSINGLSGEIPETFSKLKNLTLINFFQNKLRGSIPAFIGDLPNLETLQVWENNFSFVLPQNLGSNGKFIYFDVTKNHLTGLIPPELCKSKKLKTFIVTDNFFRGPIPNGIGPCKSLEKIRVANNYLDGPVPPGIFQLPSVQIIELGNNRFNGQLPTEISGNSLGNLALSNNLFTGRIPASMKNLRSLQTLLLDANQFLGEIPAEVFALPVLTRINISGNNLTGGIPKTVTQCSSLTAVDFSRNMLTGEVPKGMKNLKVLSIFNVSHNSISGKIPDEIRFMTSLTTLDLSYNNFTGIVPTGGQFLVFNDRSFAGNPSLCFPHQTTCSSLLYRSRKSHAKEKAVVIAIVFATAVLMVIVTLHMMRKRKRHMAKAWKLTAFQKLEFRAEEVVECLKEENIIGKGGAGIVYRGSMANGTDVAIKRLVGQGSGRNDYGFKAEIETLGRIRHRNIMRLLGYVSNKDTNLLLYEYMPNGSLGEWLHGAKGCHLSWEMRYKIAVEAAKGLCYLHHDCSPLIIHRDVKSNNILLDADFEAHVADFGLAKFLYDPGASQSMSSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELIIGRKPVGEFGDGVDIVGWINKTELELYQPSDKALVSAVVDPRLNGYPLTSVIYMFNIAMMCVKEMGPARPTMREVVHMLTNPPHSTSHNLINL
The following text describes a protein:
Function:
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
Subcellular Localization:
Nucleus.
Sequence:
MPKRKSPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETKAEEAQKTESVDNEGE
The following text describes a protein:
Function:
Exhibits zinc-dependent disulfide isomerase activity. Required for seedling and chloroplast development under heat stress, probably by maintaining plastid-encoded RNA polymerase (PEP)-dependent transcription.
Subcellular Localization:
Plastid, chloroplast stroma, chloroplast nucleoid.
Sequence:
MASSSLPLSLPFPLRSLTSTTRSLPFQCSPLFFSIPSSIVCFSTQNPDREEVRWLREEQRWIREEQRWIREEQRWIRERESLLQEISDLQLRIQSLESRNSQLGNSIPDTISNIAALLQVLKEKNRISESGLSATPMVLESTREQIVEEVEEEEKRVIIAEEKVRVSEPVKKIKRRILKVGSEGDDVQALQEALLKLGFYSGEEDMEFSSFSSGTASAVKTWQASLGVREDGVMTAELLQRLFMDEDVETDKDEASTMKKEEAGNGAVFTSVTQVPEKKQSIVKDQSDREVDVTQNRVFLLGENRWEDPSRLIGRNKPVDRSESTNTKTRCITCRGEGRLMCLECDGTGEPNIEPQFMEWVGEDTKCPYCEGLGYTVCDVCDGKKNL
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MMGDEEEPVARKRLFHGWSQDDVEEFLEQDDAVMSQLPVSSEDRALGELDFYKRYLIQCLAKGRLGVEELRRMKDVKCEAFESYLCSLVNARQRLPLNNSAPRVPKSLMYTCDVDEHGRISYQRPYYEDGRTPLQRAFGDDKVLQVRFNCQGVTSPEMYRDIIERGFDVGLRHFEYFVHKEEKKRKNMRKVKQTRQQRSFFVCTKSIAASDLVDPHFLKFRSMDACRKYIMHIHTVPCLQLYNKRLQLALSKTWTANHDPGGEIAVGCNGKPLIHTDGTGFISEDLAKQVAVNTSEEYPALLQVRLFYHGIAVKGTLLTLKTLQHKTIVYRDSMLKVKADPKLANCPSFNSLEICTTSHKPPVASLSRYVIALLLEGGVPESFFIQVVQEAIAKAMTPLQDIAAAHRLCSRFSFGDMPRRMILAGIPLTDHFLRNSLMTMIRTQLKRYAKANVPLEGSYYLMGSADPTNTLARNQVAILLENGPLHRHKVLVYKHPGMHPGDVHVFEATWNQELESCLGNSKYVIIFPTKGPRSVVHEIANSDLDGDLYWICTNEQVSNLYKPQLPWQEKRTNGTTAVPSCLGMSPEVIMSRLVAMFLRAIFKPNFAISRAATNWLIHMDKYLSTSFDNVREREFRQNCLLELADLYYLALDADKTGEMVTIEDRLLCDKIKPHFLVEENSNNPNRRKIQQQDNVYRSTSIFGKIYNLVTEVIENEAKEFTGPLMFYEEFVYGNYLSYKDLWRQHFNNYRLEISLALDEKSAEKTDEIAAQYCQMLYTGSTNLDGAKKSIYQIYQESCAIYSVVHDHVQFCLDRARAGSENEKEWKPSFTFAWKVAGEPLCHLFCERRKESGGTFSVARDVLDTITGAPGALARLRRF
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MTVISQSLKSELECHKNNSLLAQRKKRKKVKGKFRLVTKKFPRLPAEAAVLKLRECALFFQLPLISGPRTSVCFLIDKLCFPFPSFFVRKRSVLHQAPLCYSFHLPCIQIVKMEGVQPLDENVGNAPGRRFQSNKLLLVAAVIQGLGLLLCFTYICLHFYASQVPPQYPPIQSIKVQFTKCGNGTGCIITSPNKDETMKVQDNSIIINCDGFYLISLKGYFSEELSLSLYYRKGRKPLFSLSKVKSVDSIGVAHLAFKDKVYFNVTTHNTSYKDIQVNGGELIVILQTPGGFCAY
The following text describes a protein:
Function:
Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3. The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases. Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway.
Subcellular Localization:
Secreted.
Sequence:
MHSWEHLAVLVLLGVAACGEGAWAWAAQPRGRILGGREAEAHARPYMASVQVNGEHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSRPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVEPGTLCDVAGWGIVSHAGRRPDRLQHVLLPVLDRATCNRRTHHDGAITQRMMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
The following text describes a protein:
Function:
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Sequence:
MVEVQVLVLDGRGHLLGHLAAIVAKQVLLGRKVVVVCCEGINISGNFYRNKLKCLAFLRKRMNTNPSRGAYHLRAPSRIFWRTMRGMLPHKTKPGQAALDRLRVFDGIPPPYDKKKRMVVPAALKVVRLKPARKFAYLGLELPGSSGPPTSVSGVAGTTGVYHHT
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Note=Punctate pattern.
Sequence:
MQDNSSHSRESASAGDDPLGIDKLTVDYDYLLYKMRDYVQSIQLDTTELCKKQNEVMVNGIIENTIDKNIAKFKELLEKCDTLENHYEMLNQLAIITDTFKERIAEAVNNYNSLKKGASKSK
The following text describes a protein:
Function:
May phosphorylate a specific serine in the N-terminus of a myosin light chain.
Sequence:
MLKLFKRIGRKKDSKIEDFYEFGPEIGRGAFSIVRQGTHKDTGDQVAIKAISKQHVSEADMKRFTREIEIMKKLKHKNIIQLIEVFDSNDYLYLVLELIRGGELFDKIVEKGNYSEKDACNLVRQIVSAVEYMHQHGVCHRDLKPENLLCSGDDEKEEIVRIADFGLSKIFEGGEELKTACGTPDYVAPEILECKPYDTSVDMWSIGVITYILLCGFAPFYADTHHELFQKILDLEYDFPEPEWNGITDLAKDFISQLLIINPEERWTASQCIKHPWLAENHGDKELKSLDSAISSMKDYVRNREASTSNILKMRASQSTPNLHSANSNTNTNSLSSSNSNNTTSNSNNNNNNNSNNSNNNNNNSNNNNNINNNNNNNNNNNNNNNNNNNNI
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MEEERQCNFFVKKRKRLCRLLPGKGKKFCGEHINLEKGCNANQNEVDQSNTTGRIPCPYDPNHTVAVKQLAKHFKVCNSRPKEQPIYYEKGINAGSTEYDKDLEMLRLASFSLEEIQLIISKVESAYAEHVHDVKTEILHHDALKAEVENPENGVTARKHLLQLDSLLGHMNRLDLLQPDTCFVEFGAGRGRLSQWIQQAMGNLEQTSFLLVDRAAVRHKRDTFYQRDDGGYERISMDIENLILGKVPNVCNHGNRPVVAYTKHLCGAATDLALRCLMETRTGNIPQASSETLITMNKPGDEDNSQCPEHSTQQSSSQRSSSSTPQSFSGGSPDSQHISSDNGPTDVQSTIRQGSSPSEPRHHEGIPGDNSSAHQQVVETDDASRSIEPTPVSTTIPVKGVVMALCCHHRCSWRTHVGKQFFQDVGISERDFMALVRMSSWATCGTRLAKDGDKDENKKEEKGKEDGKDGKKMEGLTDDQLEGGMKETQKGSGTEELMERSKKGKERVEGENSDIPEEQASVVGSLGLSVPEREEIGFKCKRILDMGRIIYLRNLGLDAKLVSYVERNISPENVVLIAKPLNQ
The following text describes a protein:
Function:
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MSKNTSRIMFDLKRKILILIFCGSIIIFIYQIALKYQLNLRSNSWYTGYYYQNSQDNDHQHYYGHRHDHGVSGGKGGVVKFEDGSHHSHDDTSVADKLKEKIKVLCWVMTSPDNHATKAVHILATWGKRCNKILFSTESNKDPNGLPLLVINTTSGRDHLTAKTMQTFDYLYRHHLNEFDWFLKADDDTYVVVENLRYFLSSQDPTEAIYFGHHFHMYMKQGYFSGGAGYTLSRAALKRFGERSSYVCKDDRGAEDVEIGLCMQSVGVATGDSRDALGRSRFHCFNPETHIQGSFPDWYYAYDKYGSKKGIETMSDYSISFHYIPVDQIYAFEFFLYHLRPYGIMSGLQELNIGPQKPSLQKTTVSNSVPKMDTVTSSSYGTSTLPPDLINAMGGGGDLEEDEYDKDEDGADEATTTTTMKMKLMRRRKRKTTNSAADGGGGGFQS
The following text describes a protein:
Function:
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Required for meiosis, but plays no role in conjugation.
Miscellaneous:
MISCELLANEOUS: There are three genetic loci for mating type genes in S.pombe, mat1, mat2-P and mat3-M. Cell type is determined by the alternate allele present in mat1, either P (plus) in a h+ or M (minus) in a h- cell. Mat2-P and mat3-M serve as donor of information that is transposed to mat1 during a switch of mating type.
Subcellular Localization:
Nucleus.
Sequence:
MKRVAVLLKTVMCEFLKCDYNGYDRIISLLRRILTLICTPNLNGLTIKRVIDSMQSLEYIKQTCNFKLQMCISSMAFKRNNALQNCNHYAWCDDHCSDIGRPMTTVRGQCSKCTKPHLMRWLLLHYDNPYPSNSEFYDLSAATGLTRTQLRNWFSNRRR
The following text describes a protein:
Function:
Plays a key role in autophagy. Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (By similarity). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (By similarity). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (By similarity). Finally, plays an important role in biofilm formation and resistance to antifungal compounds such as fluconazole, itraconazole, terbinafine and caspofungin.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MLSDFKQQQQQKHHSHNPPNSHDDTQTKLQVAKLTQVIQKFFTKAAQIILESRAYPETSTPSLYPTKEESSKINKWFNLYMTNIPDSCKDDLKLWKGVDLTTIPPMIIETYIDLRSLPADQTLVLMDDEKHPWTVAKSRGKKQEVVLERWLIEFEPNTTDATVMVEELPLSYKQAIVLFRSIYGFTRLMPAFKVKKNLQNKLPLGNKILDGNQPISSKGRIGLSKPIINTRTNESHMTQKYFQPVHTSLGTLKISVAYRMDSEFCLHENEELLSSHFHKRDEEETKKKVSSSVSPLSSGTSLKETSTSPRKSQPPIRIQPFKVGSMSTSPPVQSPSISQPGTAPIQNQPSVPSSSLERRVSITSNKSTSNASLAAFLRNARSSTPSANNIPIINANPISGTSVPRSFSSSTGHEDSIFVNPDSASNTPRFASSFGSRASRRYSSTSIRQQTPQSDLMGQTNSVDAALSGIDADDDISDFVRMIDSKSDLRLGGGGGGGNSSVHNMSINESSYHGDALNKFQSLRSQYQQLSDSVSASLILQSRHSSRKSSLNSPAGSFDSHHHQHQQQQQQQQNQQQSQSPHTNTTSSIHSHAHSYSHSRMKDARPRSEDHQQTKFSAARRSSNISPTTAVPSSIGTPSSISSRIPHVTTIISSSDVSSTGGNRTKSAATTAIVSGMATSPSIYDYRSPRYQNVFDDDDEDDNDEEEGDREGNQLHEGRNSTESSQNQSKRIMKHIKKDEEDSEDDEDLLFTMSDMNSRNF
The following text describes a protein:
Function:
Involved in pre-rRNA processing and ribosome assembly. Is associated with intranucleolar chromatin and pre-ribosomal particles and plays a role in controlling activation and repression of a specific subset of rRNA genes located in distinctive nucleolar organizer regions. Binds specifically rDNA chromatin and may be required to maintain rDNA chromatin structure, but is probably not required for the overall histone methylation status of 45S rRNA genes. Involved in leaf polarity establishment by functioning cooperatively with AS1 to repress abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial development in leaf primordia at shoot apical meristems at high temperatures.
Miscellaneous:
MISCELLANEOUS: Disruption of NUCL1 induces NUCL2 expression.
Subcellular Localization:
Nucleus, nucleolus. Note=Found in the dense fibrillar component region of the nucleolus.
Sequence:
MGKSKSATKVVAEIKATKPLKKGKREPEDDIDTKVSLKKQKKDVIAAVQKEKAVKKVPKKVESSDDSDSESEEEEKAKKVPAKKAASSSDESSDDSSSDDEPAPKKAVAATNGTVAKKSKDDSSSSDDDSSDEEVAVTKKPAAAAKNGSVKAKKESSSEDDSSSEDEPAKKPAAKIAKPAAKDSSSSDDDSDEDSEDEKPATKKAAPAAAKAASSSDSSDEDSDEESEDEKPAQKKADTKASKKSSSDESSESEEDESEDEEETPKKKSSDVEMVDAEKSSAKQPKTPSTPAAGGSKTLFAANLSFNIERADVENFFKEAGEVVDVRFSTNRDDGSFRGFGHVEFASSEEAQKALEFHGRPLLGREIRLDIAQERGERGERPAFTPQSGNFRSGGDGGDEKKIFVKGFDASLSEDDIKNTLREHFSSCGEIKNVSVPIDRDTGNSKGIAYLEFSEGKEKALELNGSDMGGGFYLVVDEPRPRGDSSGGGGFGRGNGRFGSGGGRGRDGGRGRFGSGGGRGRDGGRGRFGSGGGRGSDRGRGRPSFTPQGKKTTFGDE
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATGKAEIRRQRENCVIFAGITYGIIFTLVAVVLGFGVYLHTLVHQENSCSMTYMYRKLEFLEIPLLTPQSDKYSFSVYNEGHRWWNRSTIEAGQIPVLFIPGSQGSGKQIRSLASVMQNKTEMRYAPFSFRFFAVDFDEEMTFMNGHIVKRQIEYVMKAIRKIQSMMRGNRKIVLVGHSYGGMIALLTTIYPEYQKDVELIIVKGAPLNKQPLVNDWFSLRFNLLLVNQWNALQNNNLSHVGVVAYSGGIRDYMIPDEWSILRNVTNRPLWAIDGVSDLGADHLAILWCNEFVRHVSRVLWSYAENLDTLTGRQVVQKFYKEDVDRNIKRAKLVRHVNDVPSKEIKIGEKYRGFRVNETQFALLIKPKRFEVLSVRVNASCVNSMTTVRYDESMMYFKNSSDGAVETWIYRALEKEEVRLVLDVTAPCSIDIQMSPPMTVQLWRFYEIVFSHLHEVGGTMIVISVFFAILVRETLFYSTTAVLLTNLVALFFVIHGSTDYTDTTTLPMALGYFMALGWRAICFVVDWLIVSRIGFVKTGHLALRDDKLMNGLYLVGSAITIMARNEGSIVLIILLAYRHHPRAVLLILPTLIPYILKLVGFPWFSTDSLIVYQLQYQPAFYAGGLYLFGLVSNLGNRQITLRLLVYGLVPAFLYLITSPLELFSGFTLIIFSTARFVTFPSRKSVTPPVPEQERVQVEQPRPIQNNRQRYNLRNRRR
The following text describes a protein:
Function:
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MWSIDTGRLWIIGTTSLISFIAFTPQIFIIIPLFDHPSTNPDCLSLLIPFNILVGLLFINYYLCITTDPGRVPKEWDPIGLIESEEHDRAKILSLGQLRFCRACKVSKPPRAHHCRTCKRCVLKMDHHCPWVNNCVGHHNYGHFLRFLGFVDLACWYHIWMISKRVFGEFAYGPEPSKTEMIILVLNYVSCLPVILAVGVFSLYHLWAVLSNTTTIEGWEKEKARELRRKGRIQQFTYPFSIGIYRNLQVVLGPNPLLWWLPQRMSGDGLRYPTLATIDPLEQYLWPPRDLFTRRAPQLRRRQFEKEAFTYGEERLNPDLIPSGSMRGQSVPQGVPRRTVSPYHADYDVESDESEESDSGRLANGHAVDFSASDEEPLSTLVARRNQASGVPSHQAAVMARRPLVRRGSEGVEIKPVGPHWSPAEFSADPLVDQPTHDDERWLQVEGSEGSDGWD
The following text describes a protein:
Function:
Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones. Probably responsible for energy coupling to the transport system (Probable).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MSADNHQVPIEIRGLTKHFGSVRALDGLDLTVREGEVHGFLGPNGAGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLWPSLTGGETIDLLARMRGGIDNARRAELIERFGLDPTKKARTYSKGNRQKVSLISALSSHATLLLLDEPSSGLDPLMENVFQQCIGEARQRGVTVLLSSHILAETEALCEKVTIIRAGKTVESGSLDALRHLSRTSIKAEMIGDPGDLSQIKGVEDISIEGTTVRAQVDSESLRELIQVLGHAGVRSLVSQPPTLEELFLRHYSLGPEVAAEQQVATP
The following text describes a protein:
Function:
Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.
Sequence:
MKSTSDLFNEIIPLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQDLHQELTKNLTADEVATLEYLLKKVLP
The following text describes a protein:
Function:
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEEVGLDLEELRQLQNIAKRPRVLNLINSEISNLEKLRDSAVSSNAKPKVPVTVPAPVSSSGKPVSSSALNYVTLGTFSWDQDNDKVKMYISLEGVDEDKVQAEFKPMSLDIKIHDVQGKNYRCAIPKLCKEIMPEKCKVLVKPKRIVITMVKSSRGNWLDIHHKEDKIKPSLEKEKDPMAGIMGMMKNLYEDGDEEMKKTIAKAWTDARSGKAADPLKGL
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCSQEEPSMGTENQTCVTEFILVGLSSGQRTQIPLFMVFLAIYLLTVLGNLLIIVLIHTDSRLHTPMYFFLKNLSFTDLLFSTTIVPQMLFHLLVTRKTISIAGCSIQMIFSLVAGCTESSLLAVMSYDRYVAVCKPLRYATVMTQRVCVQLTVGSWASGAFVSLVDTTFTLSLSYHGQNMINHYFCEPPALLKLASEETSKAETAIFAMGVVILLGPLSLILFSYWNIISTVIQIHAGERKLKVFCTCGSHLIVVVLFYGSTVFTYMRPNSTKMNEGDKVISVFYSVVTSMMNPFIYSLRNKDVRESFRKVLGR
The following text describes a protein:
Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSNSIKVVCRFRPQNRIENEQGAQPVVKFEADDTCALDSNGAAGSFTFDRVFGMSSRQKDIFDFSIKPTVDDILNGYNGTVFAYGQTGAGKSYTMMGTNLDNDDGRGVIPRIVEQIFASILSSPGTIEYTVRVSYMEIYMERIRDLLQPQNDNLPIHEEKNRGVYVKGLLEVYVSSVQEVYEVLKRGGDARVVASTNMNAESSRSHSIFVITITQKNVETGSAKSGQLFLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINNLTDGKSSHIPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNAEETLSTLRFGMRAKAIKNKAKVNAELSPAELKALLRKAQSQVTTFETYVSTLEGEVQLWRKGESVPKEQWAPPLAGVSGAKAEAARAPRPSTPSRLAMESRAETPLTERSATPGIPIDKDEREEFLRRENELQDQITEKETQIAAAEKTLRDTKEELTYLKERDAKVNKDNEKLTSEANEFKMQLERLAFESKEAQITMDSLKEANAELTAELDELKQQLLNVKMSAKESSAALDEKEKRKAEKMAQMMAGFDLGGDVFSENEATIKKVIDHIDSLHEQSSAGEAIPPDEFEELRVKLVETQGIVRQAELSMFGSSSNDANVKRREELEQRLQVLEQEYEDLLERNLSEGDVAEIKERLEKAYANNQDIKVELVEDLKKEVAQKSAEIEKFKAVNEDLQQRVKSGGATNGTAPSSASGKTVQQQIAEFDVMKKSLMRDLQNRCERVVELEISLDETREQYNNVLRSSNNKAQQKKMAFLERNLEQLTHVQRQLVEQNGSLKKEVAIAERKLIARNERIQSLESLLQDSQEKLTTASHRFEAQLSAVKERLEAAKAGSTRGLGSPTGGFSFGGAGSRIAKPLRGGGGDGQIPTIGNLQNSETGSTGSTKRSSWFFSGQK