lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine.
Subcellular Localization:
Nucleus.
Sequence:
MSTPSIAPAPAPLVPALAAKPAISPSPGPGTPGSITSKEWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVNELEEQIKKIEDEHEIHIAAFKEQITNLSREVEQCRSEMTWWRDRCHALEKEVSVERSAKEAIVKEFRSSLSDREAVRSDKGLAPLTTSTPQARSSDRPDNGDASNNDSGEGREEVPLGCNDCSTSHCQCIEDAFTMPGVVAQEQSRRLDTTKPGLSEPQIKPDPEEMEIDFTSRFAATQQQDQSPTSVSSPAVDPCGFCSDGTPCICAEMAAQEEQRPRRNSFENNRLAPIQNLSQFTPPPSDGDVRSDVTLPPISQATNPCANGPGTCAQCLADPRRTLFCKTLAASRSPSAAPSGCCGGKGADGGCCQSRNTNVSRGRSGSNNNTSSGSSAAPSLTLSCADAYTTLSRHPNFSRATDELSTWLPKLHTLPKPRDFPLTDRGVPRAALEVEAASVMGVLRYFDRRFADK
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAQRTSNAVANKRRGKKRQSRTEISSSSESDSDSDSSVPSQKNESVKSKSVSPSSEDTPEPVAAPAKKSKKQSKPAAVEDEASQKNDSAESTSPSSSPSSSEAPEPVAAPVKKSKKKSKPTPVEDEDVSMTDARPAPVIKKSKAPTEDFSAIYLRKIAAELGDDIDKVREAQDFKANSVPMLIHALKQGESMFSAEEKRRVVGAAGH
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MAIASTLASTQNPFLCLRQPPSPGNRSVVFRRCQDPCGRRWISRSIRACQPSDKVSGQFPFDFMYSSMLIPSSCGEWNRIHLGGDGGISASAQRLYFGKELLSFASDNFLPLALVSGVGLGFANPTLGCLADKYSFTKISTCGIFIISGLTLRTEAIGAAVKGWPLGLFGLISILLLTPSFSRLIMLVQLQPRELVTGLGIFCCMPTTLSSGVALTHLAGGNAALALAVTVASNLLGILTIPFWVSRYIAGGVGVSFPTDQLFRSLIVTLLIPLIIGKVIRESFKGFANFVDNNRKLFSKINAICLSLVPWIQVSRSRSLLLSVQPKVFLAAVGIGILLHLSLLAFNAVSIRILSGLTGGSKSSKENSTAVLLVSSQKTLPVMVAVVEQLGGAFGETGLLVLPCVAAHLNQIMIDSVLVNLWLRRGKDTSTKVKTA
The following text describes a protein:
Function:
An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the mTORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the mTORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development. This component is required for activating mTORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate. GATOR1 and GATOR2 act at different stages of oogenesis to regulate mTORC1 in order to control meiotic entry and promote oocyte growth and development. After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate mTORC1 to slow cellular metabolism and promote the mitotic/meiotic transition. At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate mTORC1 to promote meiotic progression, and drive oocyte growth and development. In addition to its role in the regulation of the mTORC1 complex, functions independently of mTORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues.
Miscellaneous:
MISCELLANEOUS: This protein rapidly evolved the ability to recruit the methyltransferase unmet at an evolutionary branch point between honeybees and mosquitos, corresponding to the emergence of the order Diptera. This allowed the GATOR2 complex to repurpose the substrate binding ability of unmet to function as a nutrient sensor for methionine.
Subcellular Localization:
Nucleus. Lysosome. Note=Accumulates in pro-oocyte nuclei in early prophase of meiosis I. In egg chambers, detected in lysosomes and autolysosomes of both fed and starved females.
Domain:
The WD repeats are important for recruitment of the methionine nutrient sensor unmet.
Sequence:
MSGNTHGLSWFPHFPDKFVSWGQEIHLYEVRRKDDHSQKSRLPYISVNYLANESRYQYARCVAASYHSDQPIIAVGLADGKVGICNFRDTYDSSWEYTPRQQRMCTCLAWNELDANILAIGHDRHRNDTCITIWDIERGVPKETANFFGVGESANSICWDRNHRTVIAGMSQKMIKLFDLRQSNATCQSIQTKTVQGLSVSPNGNYLCSYVDSVITLWDPRNIKSPLRQIQSSKNHLQIAWCPTRTSLLSSLQRDSSYITLYDIRSVDTDNSGEIYHVKRQISPFPARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNRRKLPLLMQRPLYTPASPTSTAATPTQQQPTSSCSTNSGSSLDFSTPGGSPFNVDLLKPELFELDLVDETRQRALEDYGIKPDNKRFGELHLTPYLRNVWSTLNNVYSEDRLTGLKATLGINLGHTSEALMASSRIESQVLQWPEGINNSNKLICYRSEQRDLALQLCGWAFEQELDRFIDQLYANKEYSRAAMICVFHLKIFHACNILSSAADNMRDPSMYRITVIALSSFNADRCSSTWRNQRSSANMQIHDPHLRAVFSFLTMEKDNFDAVLKEEGVSLSDRMAFACKYLSETKLADYVAQQIQAAIDGGDLNGLLLTGESQDGIDILQSYMDTSFDVQTVALVAINYFRQELFEDKRIQYWIASYLDHLNSWGLWEKRAELDIKIESIRPSSRSSRTVFLSCNFCGKSVSNALLDEPRPRSTTTSTNRLSSCPSCRKPLPRCSLCLMHMGTMVNMSNGETPTTTPDVPGWQTKPFSKWFSWCQTCRHGGHTEHIMQWFKQNSECPVSSCNCRCFDMDGTKPNTLRDIS
The following text describes a protein:
Function:
Unlikely to encode a regulatory protein. Has ATPase activity. AmiB and AmiS may act jointly into a two component ABC transporter system.
Sequence:
MPFLSDMLDQSRRQQDEEQALARENLAEASLLQAHLSHRSALRSRFRFDPAAVMDCLRAEVLGQDPALQAVEDMLKVVRADIADPRRPLFSALFLGPTGVGKTEIVRALARALHGDAEGFCRVDMNTLSQEHYAAALTGAPPGYVGAKEGTTLLEQDKLDGSPGRPGIVLFDELEKASPEVVHALLNVLDNGLLRVASGERTYHFRNTLVFMTSNLCAHEIQRYDERRQRLPWRLLPVGGERRRRDIDGMVRARLLKTFSPEFVNRLDSVVTFNWIERDVVARLVELEVQRLNRRLEKHRCRLEATPEVLAKIARAGFDRQFGARALRRSVRHHLEVPLAEHLLDHHQPGDGNCTTYLASLEHERVRFVRR
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent.
Miscellaneous:
MISCELLANEOUS: Present with 217 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The AWS and SET domains are necessary for transcription repression.
Sequence:
MSKNQSVSASEDEKEILNNNAEGHKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGTFKNNDFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQNIADALGVTVSMEKKWLKLKKLSGEPIIKNENENINIEFLQSLEVQPIDSPVDVTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHGYTCFSKMLKLFITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPAKFPFLKPNCDELLEKWSKFETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKTKLHYPPSGSSKVFSSRSNTQVNSPSSSGIPKTPGALDSKKHKLSDEEYERKKQKRLEYERIALERAKQEELESLKQKLKLENERKSVLEDIIAEANKQKELQKEEAKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFFASFVPNLIKKNPQSKQFDHENIKQCAKDIVKILTTKELKKDSSRAPPDDLTKGKRHKVKEFINSYMDKIILKKKQKKALALSSASTRMSSPPPSTSS
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKLPEASETQNARDDRVEQLWRKLDTKQRGEINLQELQKGLRRIDHPLKDASDLLRDVVKAMDKNGDEVIQYEEFRLFVEKTEKELFVLFQGIDKDHDNRLDKDELQVAFKKAGLTISKPKLDLFFTEVDMNNDGYITFDEWRNFLLFLPATASTQPLKAVLSYYQSAVSVNAEGDTSIREDTLEGLGTKTNFLKLLFGAVFSIAESHRGRASTIHIGEAPSPISSNKKTAKMDMAEIQALNAIDPVDDEYGRDIDPIHPRTEMMANVLRGRHRQELTQEVSKKLKPSERSRLTEILPDPGYFAAGAIAGIFSRTATAPIDRLKVYLIANVSAKRAPLEAAKQGNVAAVAKMAGQPIILAIKELWNAGGIRSLFAGNGLNVIKVMPESAIKFGSFEAAKKHLAQLEGHGNSRKINPYSKFVAGGFAGIMSHMQCETVAGGLRGNALIVATAKQMYKQGGIRCAYRGLTMGLVGMFPYSAIDLATFETLKAYTTRRNMSRFGYSAEDATPGPFVTGAIGAFSGAFGASIVYPINLLRTRLQAQGTVLHPPTYTGMMDVAQKTIKNEGFRGLYKGLAPNLFKVVPAVSITYVVYEQAKKSMDLH
The following text describes a protein:
Function:
Functions in the bile acid 7alpha-dehydroxylation pathway, which forms secondary bile acids via the 7alpha-dehydroxylation of primary bile acids, and is carried out by intestinal anaerobic bacteria. Catalyzes the dehydration step in this pathway, yielding a 3-oxo-Delta(4,6)-bile acid-CoA intermediate. In vitro, can act on the free bile acids (non CoA-conjugated) 7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoate and 7-alpha-hydroxy-3-oxochol-4-enoate, but not on 7-alpha,12-alpha-dihydroxy-3-oxo-5-beta-cholanate, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate or 7-beta-hydroxy-3-oxochol-4-enoate.
Sequence:
MTLEERVEALEKELQEMKDIEAIKELKGKYFRCLDGKMWDELETTLSPNIVTSYSNGKLVFHSPKEVTDYLKSSMPKEEISMHMGHTPEITIDSETTATGRWYLEDRLIFTDGKYKDVGINGGAFYTDKYEKIDGQWYILETGYVRIYEEHFMRDPKIHITMNMHK
The following text describes a protein:
Function:
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. May play a role in the interconversion of ribosomal RNA-folding intermediates that are further processed by DeaD or SrmB during ribosome maturation.
Miscellaneous:
MISCELLANEOUS: In vitro, can replace RhlB in degradosome and facilitate the degradation of RNA by PNPase.
Subcellular Localization:
Cytoplasm. Note=Ribosome-associated. Can either bind to the intact 70S ribosome or to individual ribosomal subunits.
Sequence:
MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVRALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFIHDIRRVLTKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASDQVTQHVHFVDKKRKRELLSHMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKKEIPRIAIPGYEPDPSIKAEPIQNGRQQRGGGGRGQGGGRGQQQPRRGEGGAKSASAKPAEKPSRRLGDAKPAGEQQRRRRPRKPAAAQ
The following text describes a protein:
Function:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRKVIQIKPEIFRQIKPLCRHLTIQADPKNTEAITLSDGCVKRLKEIREENGRLRVVVTNGGCSGFQYLFNLDKNVNEDDRIFEKDGAQVIVDQMSLDLIKGSIIDFREEMIRSSFHVVGNPRAEMGCSCGVSFSIKE
The following text describes a protein:
Function:
Actin-binding protein which is involved in F-actin stabilization. May play a role during phagocytosis and pseudopod formation by contributing to the maintenance of F-actin.
Subcellular Localization:
Cytoplasm. Cell projection, phagocytic cup. Cell projection, pseudopodium. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=During phagocytosis, recruited to the phagocytic cup by 14-3-3 protein 3. Co-localizes with F-actin in pseudopods and in phagocytic cups. Localizes to the site of phagocytosis until scission of the cups occurs.
Sequence:
MSGFDLSEVAGPVAEVIDDKNEEVEFVVFGVQTQPNKLVVDAKGKGGLEEVKAALKEDALQFAYYRTISGDEESKRVKFVFISWAGEGIKKPKLRAVMSILKGDVKNVINNFHIELHATSLDDLVEDEIAAKIKKAGGADYSFNTTSN
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MSYNCCCGNFSSHSCEGYLCYSGYSRGGSSYPSNLVYSTEPLISQHLPAGFLSLQGLSGDLLGNP
The following text describes a protein:
Function:
Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys-32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes.
Domain:
Adopts a GT-B fold and acts as an inverting enzyme that converts the beta-configuration in the dTDP-beta-L-rhamnose donor to the alpha configuration in the N-linked (Rha) arginine product.
Sequence:
MKATWDIFCSVVDNYGDIGVTWRLARQLVAEHGLAVRLWVDDLNAFTPMCPGADATAAQQWQHGVDVRHWPAAWLPVAPADVVIGAFACQLPAAYVEAMRARPQPPLWLNLEYLSAEDWVEGCHGLPSPQPNGLRKVFFFPGFTDKTGGLLREGSLLARRDGFQQSAEARRAFLQGLGVDLVPGALLISLFAYENPQLGNWLDALATADQPCHLLVPQGRVVAGLSQWLGEGPLHVGDVRTRGALTVQVLPFVSQDDFDRLLWSCDFNAVRGEDSFVRAQWAGQPMLWHIYVQDENAHWEKLEAFLAHYRCGLSDDADAALLGLWRAWNMDFDMGQAWRAARQHWPELQQHARLWGARQAAQPDLATALVHFYRNSL
The following text describes a protein:
Function:
Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSSSDLIKEDDYVFISGRGLNKIVQIKKDVTVRLGRSGAALATTLIGIRYGGVCHLDHARKKFVESDEYPDLDITEVGDGEEVKDNRDLVDDNTNQQLSNDEVAAIRRDKGLDELLQALVEKSASYRTKTNFAQEKYLKKKQKKYGTLFKVERVTVDNLAELHVPTINPSDNTSEDARCLRLRADTVALILHHSDVHHNSRVILYEKTNGVLPASLLTRMSDEGRIFQILDKNAQPSPTTAVKVLKLPLVKERWKAVPRNRGFLEGLEEPDKDSARDTAEAAEKNAAGAAAGKGLQRQDICASSTQWVKGLEARQLLLESSADSLVICDDEAPQRAVADLLPFLAFGGHIVVYSPFLEDLTGIFLALRDDCVNLQISETWYRHHQVLPKRTHPTVNMSTAAGYLLTAIKVCRNPAAPRLTAAVTAPALSATTHAGHKRSATEELNGMASKKSATREASDEGNAN
The following text describes a protein:
Function:
Involved in the genetic cascade that governs left-right specification. Required for correct asymmetric expression of NODAL, LEFTY and PITX2 (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with the basal bodies at the primary cilium.
Sequence:
MVLAGLIRKLGHQLAEIRERALKSILCKIEHNLICYADLIQERLLFLHLLEWFNFPSVPMKEEVLNLLSRLVKYSPAVQHLIDLGAVEFLSKLRPNVEPVIQAEIDGILDGLFILPSEVPALCSSSYHTDQIELSQQPEVLTGYFPQDKSNFQQMEVPPGPAGNQAVKWLRFSVFPWLPLTTTDRHVLSSNESSLRSSNHTLIWNTCELLKDVIMQDFPAEIFLQRPKIVQGLLCLVKLAFGGDGKHRLALQSVSCLQQLCTSLRNRLNFYRDPNFFSSRQDTVSQNSSLSYCHEARGPYHSPNPSPGSSSSRPSVVGRTGQRPRGDGQDWDAVSSSGSSSHTHVNSRISVHSPLDVAPVDLPELEAEDTLELQFQQLSLPQFCISTLEAAAPLLRTGSREMIIRVLELLAEDMLLIGQAISSEIWDDNSLFAINVKEKLLQVLGSLGETMCYRKTSFSMEQAEAVLVHHRMAFVSISLFTVRLLQLLLPVEKASEFLPESMSAALFFVSLDMPISLEYPEIHDTVVAYLEQLDSENYSIYKRTAEAVYSIECTCNFLSDVGKEGEKNLLELVELADQALRSFSYHQHSPLIKEIICICSKIWKSAQASPLLQGESQKVFLHMLSHPLPQVKVETYQCCLEIVKECLGVQNVTKPVSSLCSGIHFLLHPKVLYEISAFGIQESKNEVNAAAKAILLYLLQGRLMMTALTWNKFIESLAPVIPVLQGYADTEDPLGNCILLLSKVSSEAGEGALPCTARLKSVLRLLLVKKPSVRSLALKLLAFHLTSEEGADKKRPFIDAGVLSRVTNLFIVKKPIDLKLDDRRELVIKLETVKKVCDIFTSDDVDLVLRKSAAEQLAVIMQDIKMHTVVKKLCLVEKIIGHLNEFVGQDGEVIECLIQPCLTLLRKVLYADPVIRVSLSQQASLLTLLLRVSLIFHEDCTVVAEVGALFCLLLFDEVSRMDTWSDTLSDKPSLSSVFSLPVSVFRRYHLPVHVTGHHAVSPYSIVLPLPTECLTLKPVSDMLRIAWNLAWYHGSDNLLKQMTSEAKIQEFLDTLQLSTEDILALKITYTDSGLKDCLQSIIQAGGHRDVRAAITRMSFYLLNDKLSLKDDIGPCGVTLKSLAWHTVLNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNPSIELLNWILELLLRHNPSPLLDLLVLTDSHAGEETDDVRTAVRQQLQKELISLLNSLLLVFMTVSDRKCLELFYVFQTQLSLKLLQCLRVTDAPHFYGLPSLERTLAGMAHLTAFPGWSAHSPLSKPLEICGKYLSGLLEVITSFYVERGGNAMSFMGKGVTKSTGLCLLHLSHEMIVQAPGSEWMPLWFLPLGSHSEEHAPTQQGLAWLIPLWVDRDPEVRFTSLGLGSALTTIEAGCVALANSCQNISGGLWGTVVNILLDQSECSLVRREAAFILQNLLVIPMPSEIIKDYTWQGPCVHDEDSGLSLSGKPALQALLYHCRFYEHLTHMVKHCYVGRYIFDFNFSAFTETSEYSDLNGLDDSFKFWRAPSGTSTQDHEPSSLSTSETMVAASVVSSEIQPLLPSTLLPETALDQFVTQGQREMRPVRPRDSLLSTSLNRQYVFVTPSLLSAVCSLLDNLLAVTPRDAANAFQQAHLIELLCSTVDASLIEMCIQELKTPLPLPSAVEHIQAQASFFLEYLSSLSQLLKSCLLVEPKLVTQDELLKPLITNVIRVLIVCPKDVLDVQLVLAFYRTWTHLFDLLATLLRKAGAVSLVPLTSALAKHWEAVTDTLCRCVGLSFKCPALTIASLQFLSVLLAEEEKRRVQDKDKTNEGQAPTVALLLDGTQGSLSSSERLNETILQCYEGISPKDVLKRVAANALLSLLAVSRRAQRHALRSDLIENCMEQMKHINAQLNLDLLRPGKAVLKKKEDGFIKELSITMQLLRNCLYQNEECKVAALEARLVPVLHSLWPWLLMEDSLMQIALQLLCVYTANFPAGCSSLCWSNYGQCIQTAHRGTPSSSLILCILKLASQMPAENTTIQQLVFMFLSNLALSHDCKGVIQKSNFLQHFLSLTLPKGGNQHLSTVAILWLKLLLNMSFGEDGQQMILRLDGCLDLLIEMSKYKHKSSPHMPLLIFHNICFSPANKPKILANEKVVTLLAACLESENQTAQRIGAASLWALTYNYQKAKATLKNPSIKRKVDEAYSIAKRTLSNSEENPLNSYYLKCLENLVQLLNYS
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
Subcellular Localization:
Cytoplasm. Endomembrane system; Peripheral membrane protein.
Sequence:
MAQVNGDESVSKYAAVPESGVARLHSAAVPIKQPSVNGKALCSNGSSSSISSFRLSVGSGSSGDTDIQYIKPSELFPKKLAWVEGGSANTIPPPFPLLPGEDIIYEGRAVEGTLYISNYRLYLSKKVPTEVFAIPPALSPQSSVRDVNVPLGLIESIECKDIFYINLYCKDARSFRLIFVNGECCQDWLKRLSQSLNLPRKPEEVFSLAFYAWTRDDDENHLTKPPVNQTMPWWRNLSNYDQPLTGEKLFRFEVERQGYDDSVTWRISSANADFKLSPSYPTHLLVPTSISDDMLEAVAAFRSARRLPAVVWRHKRNGAVLGRCSQPEVGWLGWRSQEDETLLLSILNSCFYDSANNPLRSRHPTPNKDMNSTNEEWNGEGSLSISNGSSSNVECGSLKDLSEDSSCFTQGHKKKMLIVDARSYATAVANRARGGGCEFPQYYPQCDIEFMNLANIHAVRKSFLLLRALCQSAIGNLATTDQSNWFTQLDSTRWLHHMANLLRASWYTAVNLEEHGRPVLVHCSDGWDRTPQIVSLAQIMIDPFYRTVKGFQILVQREWIEFGHKFADRCGLLGGCEDTNERCPVFLQFLDCVHQLMSQFPTAFQFNHAYLVKMVQHIYSNLFGTFLLNTVQERTSHRISERSHSLWSFLLQKSNEYSNYLYELTEEPIWPSYQVRDLYFWSAVYTAELGSMPNDCQTGDCRENSTTVNLNTSSSPCSSGYATPQQTALTDSMVDTLAWKNLNIKGGVRNPMEDSTDTLVDDGHKPTTVLDQSDGDMEAGESFPLLEPEPVKEPSYKEHQDPLPSMTHFRSKQLKSPLEEPLSLPQNIASEEDGEESEVDGRNSYLNNCPTCKRNWDLLNRNQTHSKADPAPMTFNDGEEKAIATTMTRLGDSTATCLGYDLDGLLPSIDRQQVRLGQILAAKDAELDALRRDLHQTRVALCRQVCHDCKSSRKTNSSSKSNSEGLIEESCRDGSPGRNESSDCSLGGLNSSPSSWENVDEKEIGDKAPVGPPILWVPDHLAPSCMRCSTPFWMARRRHHCRNCGKVFCSECADRDLPLPHQNLFQPVRVCNVCYDSLSGENEDGEMCLGALQEHQDFSATRSHLGRAFSLTSLATEIPLLSGQFRGFSLKDWAKTAEGPV
The following text describes a protein:
Function:
High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain. Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance.
Subcellular Localization:
Secreted.
Sequence:
MARSNLPLALGLALVAFCLLALPRDARARPQERMVGELRDLSPDDPQVQKAAQAAVASYNMGSNSIYYFRDTHIIKAQSQLVAGIKYFLTMEMGSTDCRKTRVTGDHVDLTTCPLAAGAQQEKLRCDFEVLVVPWQNSSQLLKHNCVQM
The following text describes a protein:
Function:
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTTTGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYHVNHLVTFCLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGHVTLLDPVSKEELESYPLDAIVRCDAVMPRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRSGRGERRAAALRATQEELRRGASPAAETPPLQRRPSVRAVINTVEPSAVRGRPQVEPIPETEEARKPDPARTTTRSSDPTSPDLGPRGPELAGLQAERDVDILNHVFDDVESFVSRLQKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSPELLHFLFGPLQMIVNTSGGPEFPRSVRRPHLTLEAVALLRDNVTPRENELWTSLGDSWTRPGVELPPEEGSPYSPEFYSGWEPPATDPQGRPWEDPVEKQLQHEKRRRQQSAPQVAVNGHQDPELETESQLEEKARKWVLCNYDFQARNGSELSVKHRDVLEVLDDRRKWWKVRDHQGQEGYVPYNILTPHPGPQVHCSQSSAINLETSPPPPPPAAAPAPTQVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEELQARLAQGRSGPSRVTPGLRAPEPQLSPRSEASVVRAWLQTKGFSSGTVDALGVLTGAQLFSLQKEELRSVCPEEGARVYSQVTVQRALLEDREKVSELEAVMEKQKKKVEGETKTEVI
The following text describes a protein:
Function:
Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
Subcellular Localization:
Nucleus.
Sequence:
MKFLPLPEFEDVTSSLNFDTADCHIVGGCELYITKAPRSDRKLYKNIEQSLEAQYESVLRLSASLSPPTASDAAASLNLSRSSPFGPLSDHSSRRTFAYLIATLNASHPDYDFSHVLRPSDFHREKNLKRVMNTIDSTLFNLRPRETLDLTPPSPSAVSGSYNSEASARWGRRMWKILDEQLSLKECNIYSYSPDEDPSDADDGAIWSLHYFFFNRIRKRVCYLYVKAIPILSHTPSEGLATPVSKRTFDDGILTPNLSTSKRAKYWFGENVEIESDSDGENKYLMSDEDFRSRSVSKGTVRAMSEEIADSMEV
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Sequence:
MTKTKPAPHRVKMHVKKGDTIQVISGKDKGKVGEVLRTIPSHSQVVVKGVNIRTKHVKPRQEGESGQISSYEAPIHSSKVMLYSTKEKIASRICYTVTDDGRKVRMLKKTGEIID
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MKIPQKYIETIEKINSYLALLTLTILLYLIIFKSPHRLGTYKYLMTYLSIFEMVYAGLMILSLPQIYTKDSGFFVVMNRNVTGENFRIFNIFYFAMFSTSMANFSVHFVYRFLAIKGYKSWTQFSPSKLLIYISCPLIVGIADTVVVITFWGENESTQWFMRQVIMKISENLENLSFIGFCIIAQDENSIKYINWHSIIGIAAACLLITFSMIIMLYFGIKCYSAIRNLTNISTVSQNYRSIQNQLFFALVIQTAIPLILMHLPSAIILITCCLECSPEILGQITAIFISFYPVLDPLPNIFIIKAYRNAFFNFLSCCFQKVGPAPSESSSTLPRNVVSIMKP
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Can also produce 3,3'-diiodothyronine from reverse T3 (rT3, 3,3',5'-triiodothyronine). Does not have significant inner-ring deiodination activity for T4, T3 or rT3.
Subcellular Localization:
Membrane; Peripheral membrane protein. Nucleus.
Sequence:
MHNLLEIKIIRFLRNVFYFLHVLFNECLDTLKAYYKRWRGMKSEKPLDPSSRRARIIQATGVDLSRDPAMQSLRGVYHMAKSILYADVLRTAVRGGNAPNSSLVNYRTKEKCNILDFMKPGRPLVVNFGSCSUPPFMASFEIFSRIIDSYHERADFLTVYIEEAHSSDLWALKNNKYSIPSHITFEDRMEAAAIFKKSVSFECAFAVDTMKDETNLSYGALPERTAIILDGKVQYIGGIGPFNYDLVELEKELIAVLKK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTRLVKSPIVLIYIYRVFGIIQFCDSRSEIAKFVSRHVCILFYLFYIYISVQCYQSFKTIIFTGIFFYFDFAIMCTSYVLMFTLISNFYFRNDQLEKVLFKLKSICPKSESFGSNFIRLMVTVSAFFFIFLLFLVEDMPLVCSMELFLPLVVASFNHVFLYDVMAAIFSKFQTINNHINSISVAEIENLIILHSELTDMATHFFYFFEIPTIVGLVNWFGYALNMIYYILYVLINSISLNMWFFAIFNISILSFLFFWLFSIIWALEQTRKKAKETLSLIHDAWNEKILKRNIDSEARHLILLSVRLFVSQLKFSARNYFNVDWSFFHLALSAIATYVIILVQFNFKP
The following text describes a protein:
Function:
Erythritol-mannosyl-transferase; part of the gene cluster that mediates the biosynthesis of mannosylerythritol lipids (MELs), surface-active substances that enhance the availability of water-insoluble substrates. Mannosylerythritol lipid production is responsible for hemolytic activity of Ustilago maydis. Depending on the number of acetyl groups, mannosylerythritol lipids can be differentiated into MEL A (fully acetylated), MEL B and MEL C (monoacetylated at R-6 and R-4, respectively), and the fully deacetylated MEL D. The first step in the pathway is the generation of mannosylerythritol by the glycosyltransferase EMT1 which catalyzes the transfer of GDP-mannose to the C-4 atom of meso-erythritol. This reaction has to be stereospecific, since only mannosyl-D-erythritol is generated. The produced disaccharide is subsequently acylated with fatty acids of various lengths derived from the peroxisomal beta-oxidation by the peroxisomal acyltransferases MAC1 and MAC2 at positions C-2 and C-3, repectively. The existence of MEL derivatives which carry an acetyl group at C-2 implies that at least MAC1 also accepts acetyl-CoA as a donor. The final step of MEL biosynthesis is the acetylation of the fully acylated mannosylerythritol lipids catalyzed by the acetyl-CoA-dependent acetyltransferase MAT1. MAT1 displays a relaxed regioselectivity and is able to transfer acetylgroups to both positions C-4 and C-6 of the mannosyl moiety.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MKVALLANPARGEINVLLATAYELIRLGHDVTFLTGSSFANAIAEFRSEQNDPILAARIHFSDLGNARAVEDFTRGMQSHLKGLRKPPGDYSSMEICQIVALVTEQEFRDAATMVRDRLLEIEPDMIAVDALSPNLVTGCRMTGLPWMFTVPCSPSLTATRKSLFDPHPMGRRRQRTLMSALENLKLTFIETYRNATKKDLYARRALLKNEFGLNSMGFNGDSAIVPPLWKDRNCVGGIHFNTPGLTDSIRQPHQIHFVGAGVTSDPENHDTPVFEAASFLKQLSPSSSTTFKPLFPPLSKTGRDLDVEWMDEAYAAGQLVVYLNMGSMFLWTDAEVRSCLRAFERLYEQSGGKIKLLFKLNKPKRTPNNTGASTPTAPISSPDFEEKQRTVMGSARPVGASNLVSEKLADAIKNVTPRRKTDADKGYSQFTLSEFEGLEYVRFTRWVHDQRSIYKHPALRVVIHHGGGNSFNEAVHYALPQMILSQWFDTHEYAILAERFGIGLRSKHAPKIDENDLVNTMTRLLQGPEAEKIRRNAKVWSIRSRNAGGAPAAARLIEAQAMLFNQQKQLELAASEVRAAVDTLSGKSSVADLESETAFTPNMLSGAASTVGSD