lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Carboxylesterase acting on esters with varying acyl chain length.
Sequence:
MDSEIAFDYSPLLKIYKSGRIERLMGETAVPPSLTPQNGVISKDVVYSPDDNLSVRVYLPEKAADTDEKLPLLVYFHGGGFIIETAFSPTYHNFLTAAVSASDCIAVSVDYRRAPEHPLPISFDDSWTSLKWVFTHIAGSGPESWLNKHADFSKVFLAGDSAGANIAHHMAMRAAKEKLSPELSDSGIFGIILVHPYFWSKAPVDDKETTDAAVRSKIEAIWMMASPDNKDGVDDPWLNVVQSDSVDISGLGCGKVLVLVAEKDALVRQGWGYKAKLEKNGWKGKVELVESEGEDHVFHLTRPDCENALEAMKKFAGFIKGEM
The following text describes a protein:
Function:
Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.
Sequence:
SILAGHRRSLFIQVQTTPNPASLIFSPGKPVMEIGSSDFPNARTAMKSPLAKSLFGIDGVTRVFFGSDFVTVTKSDDTEWDVLKPEVFAAIMDFYASGQPLFYSAQVEAPKDTAIEEGDDETVVMIKELLETRIRPAVKDDGGDIEYRGFDRESGIVELKMQGACSGCPSSAVTLKSGIENMLMHYVPEVKIGFLVCSSLIILLYFDVCR
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MNSSYTAIEPDEPLDSPPSYSANDHNTTTNTTTSNPSTQPYVNQPQADQPQQPGTSSSFEPRTLLQRLKESSHPIALLFYIFFRVSPIVTYIFGTIVIHQFTSKNTFILHFIVLILLVAGDFWNLKNISGRLLVGLRWWNETTLIESENGNGNGNASGQVGESAKDFENVWVFETADPNRYINPIDSKVFWLLLYGQPVAWVVLGVLAVLKLQFLYLLFIIVATSLSMTNAMAFTKCDKFGKANNFANDVFTRAAGSMFNNFNPFGR
The following text describes a protein:
Function:
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Sequence:
MAAPMDKVAEHHKQKQICASRPAYRQGRRDRAVKVYTVNQESRYLLVQGVPAIGVSEDLVKRFALYGAVQEYRILHEYPAEEFTQAYWVKFDRLQAARVAKRKLDEYSFFGGVLHVSYAPEFETVQDTREKLGERRLLIANKTRGNDRVKQQPTPSQQERRKPQASTSTSTSILQTEPSHGTNSSYQETFPPVPSEVETFHALPAPPQHQWYHPAQHHSQWDVPKVASKQGVYPLGYDARLSVQPPNTDQSNTRNRTPTDNQAEDSRPLIGPQLPSKDQSGGSNEGATGQAVIRPDLVPRQVLAGRKRPAPPGFFGEALEEEKDSKGEDEEDNDLQKTSCPDTGSSSMNRTAIFVRQKMRQISQTRTMSSGGRSSRSGSSSSSSGSSKSTTRRRI
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability.
Subcellular Localization:
Mitochondrion matrix, kinetoplast. Note=Localizes predominantly to the kDNA disk.
Sequence:
MLLNSTRTLLLTYGRLLFAPGREGRQSRLAKGVSAWTVAAEGEKGGQLSPAPESTSCCGAAEVNEIKERDTKTCRQASSAGHNDLGLQEKEKSSGDESAFSSLGLNEEKRRALTLVLDGAPLFIGGGAGVGKSYMIQSIVTALRAKDLDVVVTASTGIAALNIGGSTFHSTFGVRVTSVGNSETNESCAVSILRYSKSLLAKVDVIVVDEVSLLHARHLEGLDIAARGAPGRIPHLPFGGIQVILCGDFMQLMHSTENCTSQDGGGDAGNKIGYRGDETTENTAGQNRSDVSSTAAVTDQGHIMSAVKNICVGERQRTSSGLIFESPLFLTCLLHLQLCEVKRHGDTAFLNDLNKLRQGVLTRRMMRSALVNPEDPNAIQLYPTRRSVAAFNESKMLELDGEEHLFRSIVESAGLSGPKGHASPNSRGANNVDGCNDVVVLHFLEKMRSSRRWQREVKKFVGQICTRCGISGIATSVVAPPYSSRQPYLKVYVHFCVSKQYDCLYPVAKMKAEWERSYYGTTPESKSARRFFGRVLFEVKHKNSLSTFLRASLKQAYSKVIESDNVLQSKRLKVGCRVILLRNLSNEYVNGSTGTVIGFQPVNKSRHLFPKGIRTQLSRKVYASLSRRPVVSSDSSAGSSENSYGGNGKEQALDVVNYDDVIVPIVRMDADGKDVAIPWLSLPLPDLQDRVFCTARVVTMPLVPAYAFTVHKTQGLTLDHSILLDCKGFFPCNHIIYVAASRVKKFSQLRMINVSPRMVTVHPGALHFSSSLPNVAEAETKWKKWKELQRMVNNGKALSASNPSVLELALYCATWKHHK
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATVQQSAAAAVAAFSSLLGVMTALINQRVPDSYMDEIFHVPQAQQYCTGVFDQWDSKLTTPPGLYLVSLGFHKLWIAFLQTPISGCSVLQLRSVNAAFGIATLPVIFNLIPLIHPARNQSFTFNAIEAFVISLFPISFFFHLLYYTDSGSTFFVLFSYYLSLRDKLFFCALTGFISIWFRQTNVIWVAFIAATICIRHLQSIDSTTALDCPGYKLKSCGDKTNHTAGLHIPQLYYFCGFSAFFGFFAVNIPQAILNFPVWIVAPAIMFETVRRFTIEHPFLLADNRHFTFYIWKNIFRQYAEARYVLIPVYMFCAWAIVRQLAKTQSVLWIVAYIGSVMLTLIPSPLLEFRYFTIPFILLRLHIATYYRSESTSGKRTTKTGFPGWGWALALALECILFVGINVSVLYLFLEKPFEWPTPTDGSNSIGHFTKMRFMW
The following text describes a protein:
Function:
Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56.
Miscellaneous:
MISCELLANEOUS: The proteins lin-15A and lin-15B are produced from a single precursor mRNA with non-overlapping transcripts where lin-15B is the upstream transcript and lin-15A is the downstream one. The precursor mRNA is cleaved at the polyadenylation site and a 22-nucleotide SL2 leader sequence is trans-spliced to the 5'-end of lin-15A to allow its translation.
Subcellular Localization:
Nucleus.
Sequence:
MLAPAAPAKDVVSADEKEEIIAKRKFRMKNVDAMRMSSLANDRMAFNKKCNALAMKFVKSAGIGTDALQLTCFQELVRHFNPIAAVVVGVKREPNSNVQAEKKTIPKVKTIQTPTQSMESVRLLQEKKASATEEQSAESASIMKHFANTIPNSTPTQSVKDVLTAAASKGQFKSSAEIFSHFPSEPSPSKPRATREGSQPSDYTYCTYLTPCILCEKALLMRESIAMTDNEAVKVLMAAVMSGHFRMATAEKAIRHERLRMCYDHVDFVYEMMCDAFEAKTESEINEMPPDRLMRGHDIYRALKRVGDLHKGKVTSNTPLYSFKNSIKSYYRNHVPRMVNGSLSKPSPKPFSELVALLQSVPPSTNLNELLNHNLSLSDADKQELIQLINGKDNRFTSRRRKIEDILDNKFAAAAAKAYRDHSEDAPSEPYIPNQSEMQNTVERRKRKLHSPEQDDAGSSSISWNAKKTKTPIDYVHLATRVLEGHSIADEALLHKSKVSYARNAFGEKPSSPTPPSAPLKFCVVNGKKYLRFENGTGPPKVVVQGNVVLRTNTLKDALTTAPRAQNQPSTSTDSSSSSEMEGIRQSFGAPQKEEEEEELVPTLLQNKPTHVESSSPVEKKPPTKTNVEKPAVRLGRMLTTAFGSMSYRTRKSVENKTDLLNQPTSASPRRMIKVVRNRNPHLAKQVAAAPSEPKHIPPTHMEKKPEELLMDPKPEPIF
The following text describes a protein:
Function:
Involved in pectin biosynthesis. Catalyzes the transfer of xylose from UDP-xylose onto oligogalacturonides and endogenous acceptors.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAAPRSRRCSLSLLTLFSITLILISVSLFVSTKPANKPFLDYRNQFSISISISSPLEQNTTNTSFVSASPPLSPLGQSNTTNTILASSSSSSSFSDHQNQNKSPSPTSKKIVIRKRSGLDKIESDLAKARAAIKKAASTQNYVSSLYKNPAAFHQSHTEMMNRFKVWTYTEGEVPLFHDGPVNDIYGIEGQFMDEMCVDGPKSRSRFRADRPENAHVFFIPFSVAKVIHFVYKPITSVEGFSRARLHRLIEDYVDVVATKHPYWNRSQGGDHFMVSCHDWAPDVIDGNPKLFEKFIRGLCNANTSEGFRPNVDVSIPEIYLPKGKLGPSFLGKSPRVRSILAFFAGRSHGEIRKILFQHWKEMDNEVQVYDRLPPGKDYTKTMGMSKFCLCPSGWEVASPREVEAIYAGCVPVIISDNYSLPFSDVLNWDSFSIQIPVSRIKEIKTILQSVSLVRYLKMYKRVLEVKQHFVLNRPAKPYDVMHMMLHSIWLRRLNLRLGT
The following text describes a protein:
Function:
GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SDO1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2.
Miscellaneous:
MISCELLANEOUS: Present with 7770 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRVESETYKRLQNDPSCIRNICIVAHVDHGKTSLSDSLLASNGIISQRLAGKIRFLDARPDEQLRGITMESSAISLYFRVLRKQEGSDEPLVSEHLVNLIDSPGHIDFSSEVSAASRLCDGAVVLVDVVEGVCSQTVTVLRQCWTEKLKPILVLNKIDRLITELQLTPQEAYIHLSKVIEQVNSVIGSFFANERQLDDLFWREQLEKNENAEYIEKDDSGIYFNPTDNNVIFASAIDGWGFNIGQLAKFYEQKLGAKRENLQKVLWGDFYMDPKTKKIINNKGLKGRSLKPLFTSLILENIWKIYQNIITSRDSEMVEKIAKTLNIKLLARDLRSKDDKQLLRTIMGQWLPVSTAVLLTVIEKLPSPLESQTDRLNTILVSESDTAAMDPRLLKAMKTCDKEGPVSAYVSKMLSIPREELPVESKRIASSDELMERSRKAREEALNAAKHAGMVENMAMMDLNDNSKNTSDLYKRAKDTVMTPEVGEQTKPKPSRNNDVFCVVSEPSSALDLEFEYEGEDDSDSQDNFGLDFVPTDIDPNDPLSSMFEYEEEDPLLESIKQISEDVNDEVDDIFDEKEECLVAFARIYSGTLRVGQEISVLGPKYDPKCPEEHIETAIITHLYLFMGKELVPLDVCPSGNIVGIRGLAGKVLKSGTLIEKGVQGVNLAGVNFHFTPIVRVAVEPANPVEMSKLVRGLKLLDQADPCVHTYVENTGEHILCTAGELHLERCLKDLTERFAGIEITHSEPAIPYRETFLSASDMNPPQNSQLGRGVHELLLSQYKITFRTFPLSGKVTDFLSQHQNSIKNILKTSTSSMDPVIESTGSSFLDKKSLLVAFEEVINQEEKSRELLSGFKVKLAGFGPSRVGCNILLSQDNLLGSLFEGTPAAFEYSDSIKNGFQLAVSEGPLANEPVQGMCVLVESVHKMSQDEIESIEDPRYQQHIVDLSGRLITSTRDAIHEAFLDWSPRIMWAIYSCDIQTSVDVLGKVYAVILQRHGKIISEEMKEGTPFFQIEAHVPVVEAFGLSEDIRKRTSGAAQPQLVFSGFECIDLDPFWVPTTEEELEELGDTADRENIARKHMNAIRRRKGLFIEEKVVENAEKQRTLKKN
The following text describes a protein:
Function:
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; [Isoform 1]: Cell membrane; [Isoform 2]: Cell membrane.
Sequence:
MQLKCPCFVSLGTRQPVWKKLHVSSGFFSGLGLFLLLLSSLCAASAETEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATELVKILEEVVRLRVAANFSTPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWINTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLPWTSRGDVLCCVENVALHQNITSISQAESFTGNNTKNPQETHNNELKVLVPVLAVLAAAAFVSFIIYRRTRPHRSYTGPKTVQLELTDHA
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Sequence:
MEGGYEQGGGASRYFHNLFRPEIHHQQLQQQGGINLFDQHHQQQQHQQQQQQQPSDDSRESDHSNKDHHQPGLPDSDPATSSSAPGKRPRGRPPGSKNKAKPPIIVTRDSPNALRSHVLEVSPGADIVECVSTYARRRGRGVSVLGGNGTVSNVTLRQPVTPGNSGGGAGGGVVTLHGRFEILSLTGTVLPPPSPPGAGAPVILMAASFSNAVFERLPIEEEEERGGGGVGEGEGPPQMQQAPSPSPRSGVTGQGQLGGNVGGYGFSSDPHLLGWGAGTPSRPPFT
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Miscellaneous:
MISCELLANEOUS: Present with 2740 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRLLVSCVDSGSIKEVLCNIGTDTSVQSALQPFHVAPHLAEGLKAYVDRMWVISEDEAILARNSGVVELVKISKHLKENEALQVDPKGESKNEKSLSDDLPKFDISEFEITSSVSDLFDDAKLESLSSKSVKRTKLVDGFVTLCPIKKDSSNNTFVAATKSGLLHIIKKGEDKKLIKLASLGLKAPVEFLQLYDLEDTDTDKYIFAYGGEENLIKLVEIDSSFQSLKQIWEAKNVKNDRLDMRVPVWPMALRFLEPSPGKTEKGKLNYQFAAITRWSHLTKYSTQHGRKPFAQIDLLPNREPLSQMEVFDAKGENVVSSLGNFQSETFNELNVITTDYKKNVFKFDGNGRMLGKVGRDDITGSSTYIHVHDGKYLLQGGLDRYVRIFDIKTNKMLVKVYVGSRINFIVMLDDVEIEMPLSPSAKAAKGKQKRKVTELEEDADELWNKLEGKVAASKASKKSKI
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Subcellular Localization:
Nucleus.
Sequence:
MEPDHIDMDALGPFKDGSSSQGVYIYKPSIQNRSLGERPSKRRKVQSEQKAEIDSAYSFEPLLNGDEPEHAVKLRYETYQQLWSEQEAKIQEILVDIDSDVYERISTFLRNLIGNRYKGCIPAALVTVGSNVSSLGRLLSRLNDQLSSTGEGGVVVLESGDAPNLKTTLKNIIRAAVTNTEGNDGYQKLLTDREGPRLLAYDLDLLSDYVNRKGVKKLVLAFRDSEAFDPTILTDLLLLLNSWLDRIPFTLLFGISTSVELFEGRLPRSTVALLRGKYFEIHDASNCVDRIYERLQADPNGRFWLGRNITAVLFERSNDYFQTPEAFSRVIKYSYMTHFFANPLSVLLANDLPGTLRSGPLCEAIRNLPSFRGYCEHLLDVGSFDQARRLLEDDEFFFQEMLRHLRSGQQKMRDIFQTVRWIQSCRRTLNLTKRTDISELSIRAMSGELLSSSSVGDMMKILRSLDSKRLGDILSSLPDGLTNVQEFRQIKRDLDALLQDYQGAEPLRSEYDSRQSVVATTVVQQRVKLSKGKSKVSKHIVDYTRIIDHFYHLLESYLTETLLRPQDLCLHEVFFLDMRSPLKETFTPRPRFAIERALSNPFDYLISTPEPCETKLSTKQPATAILFQLYLESGSLVNVYDIWQAFYAVFESEQGDSCDERMILAMFYRSLSELKAFGFVKSSRKKIDHVTKSAWMGL
The following text describes a protein:
Function:
May be involved in modulating long-term memory formation and retention, at least with respect to odor-taste associative learning.
Subcellular Localization:
Cytoplasm. Secreted. Note=Secreted to the cell surface, and to the terminals of neurites.
Sequence:
MAKGLRCKHRIRMRNIKRQHYAKKDLERLKKIVSKSSELKDVVTMKTTEPIQENKTSEGTSTDGSMEVDKMAKVINKKTLQDENGHYPEWMNQRAVKKQKQKLNKLKIKKKSGKVSKAIKW
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MSAGYGANITQNPESHQLPTVFELLAQDNLASLVTPALQHVLKVLAQTRPDLFQKCFQYSDELILGVNFLVELHFLKTHAASFSENFYGLKRVYTSSTKVSDVPSSIKLPSNIICRSLFCMVLYPYIRRKCEKIYDSSYQAENNAQTKWASKFKRAFLTIYPYIHTSLEVSSLMFLVGYLLGSLRHHSPLLLLCKVCLTRLEGEDLIKSNAAPWSSLLQLDFSVASLKTFLLKIVASTAALFKTSLTLTMYFLQFLDWWHQSGLSLQSLHKLPTPDYPKNNLLTNLANNVPIFSLCPLCRKTRCNETALAVSGFVFCYKCIYSYVQSNSKCPVTGYPCKLEHLVRIFAPDN
The following text describes a protein:
Function:
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails.
Miscellaneous:
MISCELLANEOUS: This antigen is recognized by autoantibodies from patients with primary biliary cirrhosis.
Subcellular Localization:
Nucleus. Nucleus, PML body. Cytoplasm. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus. Also colocalizes with PML in a subset of PML nuclear bodies.
Sequence:
MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAITRPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRINLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRLLPYGKQENSNACHEMDDIAVPQEALSSSPRCEPGFSSESCEQLALPKAGGGDAEDAPSLLPGGGVSCKLAIQIDEGESEEMPKLLPYDTEVLESNGMIDAARTYSTAPGEKQGEEEGRNSPRKRNQDKEKYQESPEGRDKETFDLKTPQVTNEGEPEKGLCLLPGEGEEGSDDCSEMCDGEEPQEASSSLARCGSVSCLSAETFDLKTPQVTNEGEPEKELSLLPGEGEEGSDDCSEMCDGEERQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAEQSAYENEKCSCVMCFSEEVPGSPEARTESDQACGTMDTVDIANNSTLGKPKRKRRKKRGHGWSRMRMRRQENSQQNDNSKADGQVVSSEKKANVNLKDLSKIRGRKRGKPGTRFTQSDRAAQKRVRSRASRKHKDETVDFKAPLLPVTCGGVKGILHKKKLQQGILVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSVRCGGWPLRWLMENGFLPDPPRIRYRKKKRILKSQNNSSVDPCMRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTPWNCIFCRMKESPGSQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGFRLEAEFEKNFKEVFAIQETNGNN
The following text describes a protein:
Function:
Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity.
Subcellular Localization:
Secreted. Target cell membrane.
Sequence:
MGYKSSSRTRSKQSKDPNFLLFYLLFRCERKLFEDLIIKRNFTNGRRVHNQLGTPKPIDCLVSSWSQWSLCDPCEKKRYRFVKVLRPSQFNGKACGLIDDSEPCSNMTSCIIPEVPCQGFNCNLTGRCIPLSQVCNGDNDCGDGADENDCKEVTKLCQGSKNQYWGTGSLASGINIFTNALEGVVFDNNYYGGNCNAFVIDQDKYRLPSNLERYSIEVRGYYEFVYKEYESYAAFERSVIREGMKDKKMGPDLHILNWIDIGYNFESQSLRRFLSKIRRATQSKSKILHVQCTIDIGRYKMKSKLLMFDYEFLMRVGRLPSDYSYGEYRDFIRAYGTHIISDAIIGGVYEYALILNPDGMDSEAYHSNLGKTEEDVPIVEDLAVFLRGGTIPSITSLAYKRLPNKELMEKWGDAAKLFPEVLKIKVIPMHEMWTGQNFINRLHLKNNMRSAVKEYYEETHVCHCAPCLGNGFPIIRGIASLYWFALISASTGDATGSWSCWTSWTECIEAKQKRERLCNSPIPGSIKTCPGRQKEETSC
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTSGALFPSLVPGSRGSSSKYLVEFRAGKMSLKGSTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCTTGRVYVLKFKAGSKRLFFWMQEPKTDKDEEHCRKVNEYLNNPPMPGALGGNASGGHELSALGGEGGLQSLLGNMSHNQLMQLIGPTGLGGLGGLGALTGPGLASLLGSGGFPTSSSSSSSRSQSAAVTPSSTTSSTHVTPAPAVPAAASVTSPSPVPSSGSGTSSATSPTQPIQLSDLQNILATMNVPSGAGGQQVDLATVLTPEIMAPILANAEVQERLMPYLPSGESLPQTAEEIQNTLTSPQFQQALSMFSAALASGQHGPLMSQFGLPAEAIDAANKGDVEAFAKAMQNSVKSDQKEGDSKDKKDEEEDMSLD
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (By similarity). Also functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala), and maybe also from Gly-tRNA(Ala).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (By similarity).
Sequence:
MKHNYKVKLFDELGFVRKKCKKCGQWFWTLDEERETCGDAPCDIYSFIGKPITKKPYTYKEMVKEFINFFKEHGHEPIKRAPVTARRWRDDILLTIASIAVFQPWITKGIVKPKANPLVIAQPCIRLNDIDNVGRTGRHLTCFTMGGHHAFNREDDFKYWQDETVELCFNFFKKLGIDEKSITFIESWWEGGGNAGPCYEVITHGVELATLVFMQYEKVGDNYKEIPLKIVDTGYGIERFVWASTGEPTIYDAIFKNIVNKLKEDAGVKDIDKEILAKITEVAGLMDVKDVGDLRKLREEVANKVNIPVEELDKLISPYEDIYAIVDHTRALAFMLGDGIVPSNVKDGYLVRMLIRKTLRHMDRLNLSTPITEIVAMQLNELKDLYPELLDMEDYIMEILEIETNKYRQTIERGKGIVERLLKSKKEIDLENLIELYDSHGLPPEIVKDVAKSLGKDVKIPDNFYTIVAERHENKKEVKEKIKLPEVNVDKTELLFYEYPKMKEFEAKILRIVDDYVILDRTAFYPEGGGQKADTGYIIKGDKKFRVVDVQKENNIVYHKIENLNDELKEGDIVKGVIDWKRRLSLMRNHTATHIINAAAQKVLGRHVWQAGSDVDVDKARLDITHYKRISREELKDIERVANEIVLNNYNIKSIFMDRNEAEEKFGFRIYQGGVVPGNVLRIVIIEDENGNIVDVQACGGTHCQNTGEVGFIKIIKTERVQDGVERLIYSSGLSALKAVQEMEDILEESAEILRCPTEELPKVIKRFFEEWKEQRKKIEELEKKIGELKKFELINKFETIGNYKVLVEKVEANPKEMLNIADNLATENAIVVLLNDKGNILCKRGENVDIKMNELIRYIAKGGGREHLAQGKYEGDVEEIKKKVIEFIKNK
The following text describes a protein:
Function:
DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.
Sequence:
MQEIQGFIEDILFKNDENGYVVAKIRKKKELITIVGCMPYITEGQNLKLKGEWVIHPQFGNQFKVEICEEIVPDTVAGIERYLSSGIISGIGPVTAKKIVKKFGEETLNILDNNIERLTEIEGIGKKKIEVIYDSYIKQNEVRNIMMFFQNYGVTPNQCMKVYKRFGENSISIVKENPYILTEEIRGIGFKTADKIARSLGIASNSPFRIQSGINYIINGFCSLGNTYMPLEKLISEAMDILGVKEEEIHENIYNNVAENKLKIEKVKERSCVFTLPYYYCELGVTKKILSLSLSQYDNLNINIEDEIVRFEKNNNIKFHDSQREAIKGALENGVEIITGGPGTGKTTIINCITEIFEKANMKVYMAAPTGRAAKRMSETTGREAKTIHRMLEMGVSEDDTEEVFSKGEETPLECDVVIIDEASMIDIILMNTLLKAIALGTRIIIVGDVDQLPSVGPGNVLRDLIESKCVKVVRLKEIFRQSKESMIIVNAHRINDGEMPIINKKDKDFYFIECSEPKKIVNTLLELSNRRLPKFNKSWHKIHDIQILSPMRKGILGVSSLNKELQSVLNPKNDSKKEMEFKDYIFRVGDKVMQTKNNYSLKWTRASGEGEAEGLGIFNGDVGYIEDIDEEKETIQVLFDNERRVVYENLYLDEIDLAYAVTIHKSQGSEFPVVIMPAFKGPPLLMNRNLLYTGITRAKRLVVLVGSLKAINFMVQNDKIFERYSLLKWRISNILDTEIINGE
The following text describes a protein:
Function:
Plays a key role to hearing function. Required for normal organization and maintenance of the stereocilia bundle.
Subcellular Localization:
Cell projection, stereocilium membrane; Multi-pass membrane protein.
Sequence:
MPTLWKQIVFSFASILSIGSVVLLVVALSTERWVTGTTLCQTGVDLVNASRPELEQFTGHIYYGLFQGGKTRRCGLGIRRAKIYIFPKLIKKINSGLHMIIIFFLFTAIGFAVVSLAFCIYNARKVPYQSIKGPFGLYIWNFIAGKSIAMGFACFLAAIQCHKLTEHVANYSESLFTLVILEENLGFSFWLVVASAVTHGANILVVASSKIHLPKIQTKKPEEPTATGEDFLY
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
WRCYNTERYIVTEDGLPEVRKWRPSMYRKCTDPLWLMIFFLFWTGLMFITGYAITAGSAERLIFGYDSYGNICGRTNTPVAGAALSGQDMRNKRYVFFLNSCGMGIKNLKINSVALCVSSCPQEQLNSLEDIQHFAENNGSCLCAYSFNVDTCTHNSKAAELCAALPVPPSTSFPLFNRCVPQNAECYSQFSSVLIDMVNEMDIFHRVLGGLMAGRDTVIGLCILAFVFSIVMMLIFRFISVLLVRIFLTLLVFGLLFVSGIMWWLYYNYANEPSIELETEKENMKLLFGLSIVSTIITVTLLFLMFILRKRIHVAIQLFQVVNKIIGSASSLLFQPFWTFIILILFWVYWVTVLLSLGTAGTAEVISGGQVEYRIRFGIRYMWCFTCLFVCFHSRNKSKLPRHPLLSSISNLFCYHLGTIAKGSLLITIVRLPRIILLTIYNILKEKENACARCMFKCCFCCFWCLERGLRYLNQNAYTATAINGTNFCTSAKDAFLILSKNPADTTAINCFSDFIIFLGKVLVVCFTVFGGLMAFNYHRELHVWVVPLLLLAFLAYLVAHSFLSVFQTIVDVLFLCFAVDIETNDGSPEKPYFMDQELMNFVYKSSKLEKEIKQRNKKTLHDNEHGTELQPMVRNNIHSE
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA, rRNA and small nucleolar RNA (snoRNA) precursors. May promote termination of transcription by RNA polymerase II via the recruitment of 3'-end processing factors to the poly(A) site and by the degradation of nascent RNA downstream of the poly(A) site.
Miscellaneous:
MISCELLANEOUS: Present with 623 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGVPSFFRWLSRKYPKIISPVLEEQPQIVDGVILPLDYSASNPNGELDNLYLDMNGIVHPCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLVMAVDGVAPRAKMNQQRARRFRSARDAQIENEAREEIMRQREEVGEIIDDAVRNKKTWDSNAITPGTPFMDKLAAALRYWTAFKLATDPGWKNLQVIISDATVPGEGEHKIMNFIRSQRADPEYNPNTTHCIYGLDADLIFLGLATHEPHFKILREDVFAQDNRKRNNLKDTINMTEEEKQFLQKQNSEQPFLWLHINVLREYLSAELWVPGLPFTFDLERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILLDIWKVVLPKLKTYMTCDGVLNLPSVETLLQHLGSREGDIFKTRHIQEARKKEAFERRKAQKNMSKGQDRHPTVATEQLQMYDTQGNLAKGSWNLTTSDMVRLKKELMLANEGNEEAIAKVKQQSDKNNELMKDISKEEIDDAVSKANKTNFNLAEVMKQKIINKKHRLEKDNEEEEIAKDSKKVKTEKAESECDLDAEIKDEIVADVNDRENSETTEVSRDSPVHSTVNVSEGPKNGVFDTDEFVKLFEPGYHERYYTAKFHVTPQDIEQLRKDMVKCYIEGVAWVLMYYYQGCASWNWFYPYHYAPLATDFHGFSHLEIKFEEGTPFLPYEQLMSVLPAASGHALPKIFRSLMSEPDSEIIDFYPEEFPIDMNGKKMSWQGIALLPFIDQDRLLTAVRAQYPLLSDAERARNIRGEPVLLISNKNANYERFSKKLYSKENNNNNVVVKFQHFKSGLSGIVSKDVEGFELNGKIVCPIQGGSLPNLSTTLILKMSYRLIPLPSRNKSIILNGFIPSEPVLTAYDLDSIMYKYNNQNYSRRWNFGNDLKQNIVPVGPKGITQYKPRTGGYRAFFYFAELSRNNVQPAHNYGRNSYNSQPGFNNSRYDGGNNNYRQNSNYRNNNYSGNRNSGQYSGNSYSRNNKQSRYDNSRANRR
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MLDQSEKGSEPEDMSSKSTEGGENQQKKTCTDCGTTKTPLWRGGPAGPKSLCNACGIRSRKKKRDNLGLNRAANEKKSKKGNNHNSSSNNSSRIGDGLKQRLLALGREVLMQRSTVEKQRRKLGEEEQAAVLLMALSYGSVYA