lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
MFS-type transporter involved in vacuolar amino acid uptake.
Subcellular Localization:
Vacuole. Membrane; Multi-pass membrane protein.
Sequence:
MSNPRTKSPNTNRGQGLRSERSALLNDSLSSLNGNSSYDSIKDSSKNNKDVAEVNEYPRRPESSVSVVSNSPHRQDAATTNTVSTVSVSKVLPALLLGVVLAALDNTIVASTYTKIGAEFGKFSQVSWTATAYMISCTAFQPLFGKFCDIYGRKKTLLAAYCVFGIGCFLCGTSRSLWQLVAARAIAGIGGGGMNSTVSILMSDIVPLKQRGTYQGIINVFFAIGSSLGGPVGGYFADQYTWRIGFLIQVPLIAIAFLCVYFTLNLPHHNHVSFMTRFRKIDLKGLILLIIGVTTMTCAFTLGGNVREWNDPVVISLLIASSISYLSFVYVEAFVAFEPLAPMDVLTERTCLSSYLCNFFHSVANFGWIYGMPLFFQSIKNEGAEKSGIRLIPMIIGSSLGSLLGGAVISLTGNYKKITVGSYFFGSVAALFMLRYGYSNFNWEYAVYPFSGGLGNGIAVTTTLVAIIHASPSAFQASAIATSYLFRSNGCVLGVSISSSIVQTVLGIKLRKSLDFDVDELLHHLRKDISYVHRLPEEIRQTVLDALLGSIHYSFLFVSFMFFCAFVCSMFIKNRNL
The following text describes a protein:
Function:
Effector of RNA-directed DNA methylation (RdDM) triggered by small interfering RNAs (siRNAs, 24-nt RNAs). Functions as an adapter protein that binds scaffold transcripts generated by polymerase V and recruits AGO4 and AGO4-bound siRNAs to form an RdDM effector complex. Promotes the expression of 24-nt RNAs. Required for the initial establishment of DNA methylation. Together with AGO4, required for transcriptional gene silencing (TGS) by DNA methylation and repressive histone modifications (H3K9me2) of several chromatin loci.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Note=Localized at punctate nuclear foci. Colocalizes with AGO4 and polymerase V in the nucleoplasm.
Sequence:
MDRKGKGKQVAGSDSYSGGQKRKNSVEFRDEGLRIKKRKNPEVLQFFEESAEVGYYGGSSDEDDDGLGFLNDMEDEPEVEESSKAGKGEKGKSSFVFPKEEDLNEEEFDRIMEERYKPGSGFLRYADDDIKDAIEMDALAPTSKDPPIWKVKCAIGRERRSVFCLMHKFVELRKIGTKLEIISVFSVDHVKGFIFIEADKEHDVLEACKSLVGIYATRMVLLPKAETPNLLTVQKKTKKVSEGTWARVKNGKYKGDLAQIVAVSDTRNKALIKLIPRIDIQALTQKYGGGVTVQKGQTPAPRLISSSELEEFRPLIQVRRDRDTGITFEHLDSLMLKDGYLYKKVSLDSISSWGVIPTKDELLKFTPVDRKETGDVEWISEIYGEERKKKILPTCREGGKGEGSGGGKGEGSGGGKGEGSRGGKGEGSSDFKSESSYELYNLVCFSRKDFGLIVGVDDKGDGYKVLKEGIDGPVVVTVGKKEMQNGPFDSKFTALDLNKKQISVNDVVKISKGPSEGKQGVVRQVYRGIIFLYDESEEENGGYFCCKSQSCEKVKLFTEESNEKTGGFDGTAFEDFVSSPKSPLSPEKEWQPRERYNSSNQGDIGSTYSIGQKLRIRVGPLKGYLCRVIALRYSDVTVKLDSQHKIFTVKSEHLAEVRDRNTVLSTSGDAGTGSFQPFGMLGTESSTGDWAIGAGTSSEGGNWNIGGPSTDSHESLNIERNMVQLCREKNPWGGSKPTSDVSPTVADDNTSAWANAAAENKPASASDQPGGWNPWGKTPASEAGTVSGWGDTSASNVEASSWEKQGASTSNVADLGSWGTHGGSSGGNKQDEDSVWGKLCEASESSQKKEESSWGKKGGSDGESSWGNKDGNSSASKKDGVSWGQQDKGSDESKGGSAWSNQCGDFGSGKKKDGSSGWNKSAEDSNANSKGVPDWGQPNDGSSWGKKGDGAASWGKKDDGGSWGKKDDGNKDDGGSSWGKKDDGQKDDGGSSWEKKFDGGSSWGKKDDGGSSWGKKDDGGSLWGKKDDGGSSWGKEDDGGSLWGKKDDGESSWGKKDDGESSWGKKDDGGSSWGKKDEGGYSEQTFDRGGRGFGGRRGGGRRGGRDQFGRGSSFGNSEDPAPWSKPSGGSSWGKQDGDGGGSSWGKENDAGGGSSWGKQDNGVGSSWGKQNDGSGGGSSWGKQNDAGGGSSWGKQDSGGDGSSWGKQDGGGDSGSAWGKQNNTSGGSSWGKQSDAGGGSSWGKQDGGGGGSSWGKQDGGGGSGSAWGKQNETSNGSSWGKQNDSGGGSSWGKQDGGGGGSSWGKQNDGGGGSSWGKQGDGGSKPWNEHSGGGRGFGERRGGGGFRGGRNQSGRGGRSFDGGRSSSWKTDNQENTWKSDQSGGSDWKKGWGEDSNNSKPSGSSAGGCAGNWPSWDTNSKKETNDKPGDDSKSAWGTSNDQVNTDNNNDSWNKKPNNDVGTSGEADNAWGGKTNAVAPSPSGSAAWGTGDKKTGW
The following text describes a protein:
Function:
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEETHTGHSPELDCAREHGMNLHKRHSRVTVKYNRKQLQKRLDVEKWIDEALDKLYEGKVEDMPEEVNIDDLLDLPSDEARTHRLQALLQSCSSNTEAFIAELLQKLHGLHKQEELQNEGIEHPCHHTYPHHHGNMHHHRDNHHHPAHQTL
The following text describes a protein:
Function:
Protein acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA) and epsilon-lysine acetylation (KA), possibly with a low efficiency or toward specific plastid substrates.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MGLVGCVGKSSLVSMELRWARRRKSDNAASALPRSIPIYISTLKKDINLEELRNLYSLCNHSCNRLSEKDSNVEKIVDMKKLRRAISRSDVIVSVFCKPQHVDVDDAVLYSEEESLSSSLYTSEFGRQNKDDSFLGDLFQNAVPLTPSNGQLVGFGRAYSDYGLTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERPFFKACGFGDDRMGSTTMMFTKSLEA
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGTEDQSQSPQSQQQQQQQPYGQQPYGQYYPPPQQQPQYQQPQQYQYQQQYQPQFNQPVEQSYQQQQQQPHYAMPLPPQQQPQPQYHHDQDSLMGGGGGQQPPSQGMYGPEDEYEKFPMQPPYRDLPFGIAFLAHLALLLVITISAYSKSITPYYDSHSYIDSSGEIMGLLFVILPFTIIFCVLFLFAWMRLAKGHGEGLIRWSNAVGIIQDFPSTLRLSYAAMLVNFVCFIYPRTNVVRVNRVYEGGVQTCINIYLVFSLYWTFQVIKNTLHTTISGLFATWYFQSGPNGEGMPPNPTLNSFRRATTTSFGSICFGSLVIAVIQTLRYITQLMMNNKNGLIRVIGLILNILLGIMEAVLSFFNIYVFTHVAIYGESYVASAKRCGNLFAERLGSTIINDNFIGTTISISAFAAALLLSVIGSLIGYGFQGAFYGGILTFVFGLLVIVSSLEVVYSGVVSLFVCYVLNPSILYHTKPELYAIYSQTYSLR
The following text describes a protein:
Function:
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Subcellular Localization:
Cytoplasm.
Sequence:
MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNHVASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQPDGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLIEHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISKIAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVPELGSATIHPVSLEEMKDYLVK
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MRLPLPVKKNFHMGRVLQVHSIKMAANSSTFSKSSSSAAGKQPAQSAEQVVATFQRMRQEQRSMASKAAELEMDINEHSLVIETLKEVDPSRKCYRLVGGVLVERTVKEVLPALENNKEQISKATESINIQMQAKGRELTEYRERYNIRLVGEGEGEGEGEGQGQSGASSRDSERGGSKSGAGVLVS
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Subcellular Localization:
Nucleus.
Sequence:
MTETTRDDRRRLLLQCILRARGAVHEQVLAQCLGALGGDGGELGTYVTEMNVRLRGLGYQVKRVTHALGRRYAGEQAGAEGGRFYVYVNVGASREAELATTFRPAELEFVKWAIAQVGTLGPLEAAGEQAGSAAEREVDRVLAAWQGEPCRLPQRATYAERAKTLLTYAELASSDIERLLTRLCELKWFYRTAEGSYGFDLRFLVELEEYLLENHMLMPCSTCEHVVAQGVLCTGCVAKRRDEGGCWAAWHVDCFDYQVTHVTPQCPSCEADILTAGAYLV
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
IARDFLENFGDANGEAKYMDILQDVANRKTKAIQIELEDLLNYKDLDEEFLRRVTENTRRYIGIFANAIDRLLPEPTEVLLESTENAGGSDPQIIAYSIRIYIKASPKGRPYTLREVKASNIGQLVRISGIVARCSDVKPLMQVAVYTCEECGFEIYHYGGNCSDIFDCPSEQCRVNHAKGNLIAQLRASKFLKFQEHVPKGHIPRAMTVHFRGELTRKVSPGDIVDVSGIFLPMPYTGFRAMRAGLIADTYLEAMSVTHFKKKYEQYELRDDEEEQIARLAEDGDIYNKLSRSLAPEIFGHEDVKKALLLLLVGAPHRKLKDGMKIRGDLHVCLMGDPGVAKSQLLKHIINVAPRGVYTTGKGSSGVGLTAAVQKDPVTNEMVLEGGALVRVLARVPSNFYLSFIKGESTSITVQSVVSGTGGYGHLCNRRVYKMDESDRTSIHEVMEQQTVSIAKTGITTSLNARTAILAAANPAWGRYDLRRTPAENINLPPALLSRFDLLWLILDRADMDTDLEMARHVLHVHQMKESPDLGFTPLEPSVLRAYISAARKLSPVVPRELEEYIASAYSSIRQEEAKSNAPHSYTTVRTLLSILRISAALARLRFSHQVAQNDVDESLRLMQMSKFSLYSDDRHKSGLDAISDIYSILRDEAARSNKVDGYSEAQLKECLEEYAALNVWQIHPNTFDIRFIDA
The following text describes a protein:
Function:
Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline.
Sequence:
MQFDEEWSKADPIVHALLHQKSVTPAAWQDLFYHVYKITSWVDDGPLKIRDILTRCINDYVHEANKRIRSLQTDGSLLIGYIKEWNRFYQQANILPLPFKKIDESSRRRSVPETPEESIRTVMLEKWNEIIFMNISEQLLVEALRLVKEERDGNIIDAQNVIGIRESFVALNDRAGEDPLLVYRQSFERQFIEQTTEYYKKICGNLLNELGVLEYMVYADKKLEEEQQRAKRYLEMNSPTSGKHMEKAVIALVESFEDTILAECSKLIASKDVERLQRLYRLIRRTRSGIDTVLKCIDTHIRTEGLNDMRNNAENLSTDPERYVQQLLLMFDKFSSLVREGFCDDARLLTARDKAFRAVVNDSSIFKTEMMNKKGRTLSVESKCAELLANYCDLLLRKTQLSKKLTSEEIDEKLNQVLLVLKYVENKDVFMRFHRAHLSRRLILEMSADQEKEEMMVTKLRECGMPSDAVNKLSRMLQDIELNKDMNSSFKKALTGTNNNKSIADSINMKVLNGGAWGRGGSERIRFSLPRELEDFVPEMEAFYKKQHNGRKLCWMHHWSSGTMVFGTANGGRFDLECTTFQMAVLFCFNDRAHDKISLETLRLATELPDAELNRTLLSLVAYPKMRYQILLCDVPSTTVTARDFTDSTKFLINHDFNVVKNGKSQQRGKVNLIGRLQLSLEANAEKEHESIVALRELRVQEGIVKILKTRKTYTLAQLTMELVEILKPLFIPNRKIIKEQIDWLIENKYMERRADDINTFVYIS
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTALSSKNCSLQYQLHQSPQLLEASCLLFLIILGKVLLNILLLRVRRGDARWTLMEYFCFSLALVDLLLLVNISILTYFRDFVVLGIRFTRYHICLLTQIISFTYGFLHYPVCSLACIDYWCNLSRASKQSSRWQKLLYFLTVILTWISVLAYVLVDPAISVSLKAHRGYVYQCPAYVSTQSHWLSLSMLMVLFVAFLISWQEVVALLQAMRIASYKSKAALYFPFPLHCGYALSCREALLPRLIVCFLGTWFPFVALQVLILSLRVQIPAYIEMNVPWLYFVNSFLIAAVYWFNCHKLDLRDSSLPVDPFINWKCCFVPVHRLKQVERPMSIVIC
The following text describes a protein:
Function:
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
Subcellular Localization:
Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack.
Sequence:
MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAASVKSSSSDTGSRSSEPLPPPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGAGGAGVLKIFAAGLASGANYKSVLATERSTARELVAEALERYGLTGGRGAGDSGCVDAYALCDALGRPAAGVGGGEWRAEHLRVLADAERPLLVQDLWRARPGWARRFELRGREEARRLEQEAFGAADADGTNAPSWRTQKNRSRAASGGAALASPGPGSGSGTPTGSGGKERSENLSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQMVPTDPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGPSSSRGGSPAPYVDTFLNAPDILPRHCTVRAGPEPPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLGEHFLFMYKDPRAGGSGPARPPWLPARPGAAPPGPGWAFSCRLCGRGLQERGEALAAYLDGREPVLRFRPREEEALLGEIVRAAASGAGDLPPLGPATLLALCVQHSARELELGHLPRLLGRLARLIKEAVWVTSSSSSRSHPEGVPEVPLTPEAVSVELRPLILWMANTTELLSFVQEKVLEMEKEADQEGLSSDPQLCNDLELCDEALALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELEAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSIAVNLLCVPRTSLLKASWSSLRTDYPTLTPAQLHHLLSHYQLGPGRGPPPAWDPPPAERDAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANHRHGPPVAATP
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MAEPMTEQQKTENWLEIGTIVAAQGIQGEVRVLSASDFPARFLTKGQRWIRKTPQETPQPLTLKKGKQIPGKNLYILRFTEITDRNQAEALVNYQLLVPATDRLPLEPGEFHVTDLLGLIVYDHDNGDRLGIVTDFYSAGNDLLGITLDKNPDKEVLVPFVEAIVPTVELAEQRLEIKTIPGLLD
The following text describes a protein:
Function:
Probably participates in a plant defense mechanism.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
GIPCGESCVWIPCLTSAIGCSCKSKVCYRN
The following text describes a protein:
Function:
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Subcellular Localization:
Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton.
Sequence:
MHGHRAPGGAGPSEAEHPAANSHGAATPAYADSDPGASDPGLPVPRSSGSALGSSLDPQFAGPSDASLGVAPGPRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPGQGLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPPEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPAPGPSPGPTEPAMLLQPPPQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEDEKDREIPVPPMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLYYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAASGATAEPSEAPQTRDKT
The following text describes a protein:
Function:
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKGYLWGGASVVLVTVAQLVLKWGMMNIPLLSLADINVQFLTMYFVQLASVMCGLMGYALSMLCWFFALRYLPLNRAYPLLSLSYALVYLGAVLLPWFNEPATLLKTLGAGFILLGIWLINIKPIKAS
The following text describes a protein:
Function:
Tetrahydroanabasine acetyltransferase involved in the accumulation of quinolizidine type antinutritional alkaloids (QAs). QAs impart a bitter taste to plants, acting as repellents and toxicants for herbivores and predators, and possess a variety of pharmacological effects, including sedative, anticonvulsant, anti-inflammatory, antiviral, antitumor, antipyretic, anti-hepatitis B, antifibrotic, antiallergic, antidiarrheal, analgesic and antimicrobial activities. Mediates the conversion of tetrahydroanabasine into ammodendrine.
Sequence:
MAYQMASLKLEMNEVVHVKPSKPTPSIVLPLSTLDHRPYPDSIWPIVHVYRSASNGKLDPAFVLKQALSKALVYYYPLAGKLVKQPDGKVAINCNNDGVPFLEAIANCNLSSLNYLDDHDILIAKQLVFDLHLQDENEYPHPVSFKLTKFQCGGFTIGMSTSHIVCDGWGACQFFRAIVELASGKSEPFVKPVWERERLIGSITTQPMPNPMDEATAAVSPFLPATDVMYELFKVDKESIRRLKMSLMKEISGNETMEQGFTSFESLAAYVWRSRARALNLNNEGKTLLVFSVQVRQHMSPPLSDGYYGTAITEGQVVLTMKELNEKPLSDIVKLVKESKNIAFTGDFIKNTIDTLESNPENFNVEEGPGATLALSDWKHLGFMPNVDFGWKEPINMVPAPCNMFEYEGLCIFLSPSKYDPSMEGGVRVFISLPSVAMPKFREEMEALKVTTP
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin.
Sequence:
MEDSEQASEPDWAVGPLLSDRMSALCLKAEYVGNANANFMHGIESLNGRYEALRRVRGDGNCFFRGFIFALCERLLPSAGNEALRDRIQRTIQQSKSELVAIGYSDVAIDAFWETFVDYLAAMESRSHAELVQDFQTEGGEAEYLVWYMRLLTAGYMKKNAETYQPFIDGLYPGQTVAQFCAAEVEPMGKECDQPQIAALTEALQVGVKIEYLDGSAGPGEELQSYVCSGTEEPVAITLLYRPGHYDILYPREAEQETA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MKKLTLKAPAKVNYRLDVLRRRPDGYHDLRMIMQRIDLCDEIEICLTDGPGIRVVCGREGVPDGPGNIAWRAADALLALSADKPGIDISITKKIPVAAGLGGGSSDAATVLMGVNELLGLDLPEKRLREIGVTLGADVPFFIFGRTALAEGIGEELTAIDRVPAAWIVVVNPNVPVSTAWVYQNLQLTGEAARVKIPRFFESVAEVCAILSNDLESVTIPRYPVIGEIKRELLAAGALGSLMSGSGPTVFALFEEEDAAVRAAEMMRARSWFAAAVRTI
The following text describes a protein:
Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSDVFVNFYIITDLSIFKVLVLIFLTFGYILNEKLVPDNSGVGMLMSASEAITITENFGCPADDASSGWVPGLGSAPDVPHTELSGRKAEGSGVGVQKEPPVRNFSEFDRSTMGTMVSCSQMAQKLMSDARSLCFVVADKTGLQDAVWDSVLIGGALLVDVPLNVKPEGSRESFMMLIEYAENILKCSRVVACFKKNRSDRNILIRALMHFGFSLVSPPSSMPTPATTSVSNNINNNADMMYMSCAFDEDDDEEDDDVDDDDDDDGDDSNVVVGQSDDD
The following text describes a protein:
Function:
May play a role in Golgi organization.
Subcellular Localization:
Cytoplasm. Mitochondrion. Golgi apparatus.
Sequence:
MCVIFFCADSNPQPGGYKLILASNRDEFFARATLSAAKWANADHVYGGIDLEPGREGGTWLAIGHSAGFFKVGALLNLTGEPKPRDAVGRGMIVADYVTRADEEHSILNYNERLLKDCTKYSAFNFVSIEIGSASQPARVKLLSNVPPTLEDFQNGECYGFGNSLPHSPFEKVRHGKQEFEAIVKAHGEASVETLSAQLMQLLRNKHKFWPDDELKTRAPNWGEGLSSLNVHIEEHAYGSRTHSVVLVDSENKMHFIEETMTGLDPHGEWNKTHIEKDFQNGV
The following text describes a protein:
Function:
Essential helicase. May act as a helicase in plasmid pT181 replication.
Sequence:
MNALLNHMNTEQSEAVKTTEGPLLIMAGAGSGKTRVLTHRIAYLLDEKDVSPYNVLAITFTNKAAREMKERVQKLVGDQAEVIWMSTFHSMCVRILRRDADRIGIERNFTIIDPTDQKSVIKDVLKNENIDSKKFEPRMFIGAISNLKNELKTPADAQKEATDYHSQMVATVYSGYQRQLSRNEALDFDDLIMTTINLFERVPEVLEYYQNKFQYIHVDEYQDTNKAQYTLVKLLASKFKNLCVVGDSDQSIYGWRGADIQNILSFEKDYPEANTIFLEQNYRSTKTILNAANEVIKNNSERKPKGLWTANTNGEKIHYYEAMTERDEAEFVIREIMKHQRNGKKYQDMAILYRTNAQSRVLEETFMKSNMPYTMVGGQKFYDRKEIKDLLSYLRIIANSNDDISLQRIINVPKRGVGPSSVEKVQNYALQNNISMFDALGEADFIGLSKKVTQECLNFYELIQSLIKEQEFLEIHEIVDEVLQKSGYREMLERENTLESRSRLENIDEFMSVPKDYEENTPLEEQSLINFLTDLSLVADIDEADTENGVTLMTMHSAKGLEFPIVFIMGMEESLFPHIRAIKSEDDHEMQEERRICYVAITRAEEVLYITHATSRMLFGRPQSNMPSRFLKEIPESLLENHSSGKRQTIQPKAKPFAKRGFSQRTTSTKKQVLSSDWNVGDKVMHKAWGEGMVSNVNEKNGSIELDIIFKSQGPKRLLAQFAPIEKKED
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MVMPTVVSDRMGTIDFIDYTNNHVFSKCQTDSLNTVNNGSLKHDDYLHGLANGKLVAKQMIGDALRQRVESIDSEFCEPGDEDTFFVADLGEVYRQHLRWKLNLPRVKPFYAVKCHPDERLLQLLAALGTGFDCASKAEIEQVLRMGVDPSRIIYAQPCKTNSYLRYVAQQGVRQMTFDNADELRKIARLYPDAELFLRILTDDSSSLCRFSMKFGASLDSTDGLLGLARQLGLNVVGVSFHVGSGASDPTAFLKAVQDAHVVFQQAAAYGYSLKTLDVGGGFCSDDSFEQMANVLRAALDEYFPAHTGVNLIAEPGRYYASSAFTLACNIIARRTIQDGSAVSVSDSSSMSDDGSVNNGDARYMVYVNDGLYGNFSSIMFDHQHPVAKILRAGGRTMYNSVAAHESSAEDAIEYSIWGPTCDGIDRITESIRFREILDVGDWLYFEDMGAYTKCSATTFNGFSNEHDVIYVCSEPGAMALLGL
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MNASAHKKRLSMMPGTSSASRPSMAGLPQRNNPPPQREPATPAVSELMRSSRRSMAFGRNPRQSSFGLVPQTPMAPMHTRDPRPVRDRHYQQQISQQIYEYLVTNHFEQETRHPLNQRTLSNPTQKDFKTMFEWIFRRIDPGYPFHKSIENEVHAVLRAAKYPWLDSITKSQIVAVGGQSWAYFSGMLHWMVELNTTIEKYHNHDYSGDDGPSLVDEIFNRHARESYFAYLQGDDRFARPDAELCLAEENAEFQEILAEQRAQNPLPEGEDDELDEELSRLEAKWGKIEEAKLLGKNLADDIVKLGAFVDARKEHNARYASQMSQATAEEDNVTSEVESLSRQKLKLQQTIQDQGLSPAELDKLHLDMERQQKALNSLDEIIDEGRQVVSNKESTALAVFDALDRVIKEYTSSVLSYNAWVASDNDLPEIPESVYLIDLREPLSEENLGRHPSVILGGVDPRNQIRPEIVRICNMVTSKVKALQEEALRLQEEIETNQEKLVSQKRHIGELEAKSRRLRETRNALEDSASMNENENSQNTERLENQFVQAQSETALAQSQLKGLQVRLQDAEHERNKLSVEVQQARERLSQDILKQAEVMVAFKAMVQTKLQDFEMFVRANVEEEIRGDHN
The following text describes a protein:
Function:
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKEKVSVPFMLLGILFNVCLIAANLLETKVIQVGSLTVTAGLLVFPISYIINDCIAEVWGFKKARLIIWSGFAMNFFVVGLGLIAVAIPAAPFWEGEEHFDFVFGMAPRIVAASLMAFLVGSFLNAYVMSKMKIASQGRNFSARAILSTIVGETADSLIFFPIAFGGIIAWKELLIMMGLQIVLKSMYEVIILPVTIRVVKVIKKVDGSDVYDTNISYNVLKVKDI
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MATTQSHTSDLTSEEQPASLDIMKEQTVPANNETSASFKSSQEAPVVVHPAKVAPLTGPYGLAGDFAGHLPSSILSPQAQGFYYRGYENPTGEWDEYSSYVNVEGLDITSPVGFNENASLVYQTGYGYNPQMPYGPYSPAASPLPSEGQLYSPQQFPFSGASPYYQQVVPPSMQYITSPTQPELTSLVGVDQQGDNIGPRQSYHPHPIGPFNGNQPNLGFPEWQQGFDGGIWSDWSKPSDMHRHSSSISPALSPQPLGSYGSYGQNIPMGSQRQRSFYGFGSGSNSYNRGYMHSGGRGQGSNYGSRLISNVGMGNQGWIGVDNSRGRGRVSDPSLGGAYNGTFDILNEQNRGPRASKPKTQVLEELDSAADSKKNNKGSAKEHEESNNADFVTDYTNAKLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDEKEPCPLFLLFSVRV
The following text describes a protein:
Function:
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules; Part of the YfiB-TpbB-YfiR (or yfiBNR) system, encoding a tripartite signaling module that modulates intracellular c-di-GMP levels. The system is a key regulator of the small colony variant (SCV) phenotype, and plays an important role in biofilm formation and in vivo persistence. The c-di-GMP produced by TpbB/YfiN stimulates the production of the Pel and Psl exopolysaccharides, which promotes surface attachment, generates an SCV phenotype and confers resistance against phagocytosis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The presence of the HAMP domain is required for dimerization and catalysis.
Sequence:
MNRRRRYTGSNPSLRRVLYRAHLGVALVAVFTAGLAVTLVGLLTLRAYADPNQQLIARSISYTVEAAVVFGDAQAAEESLALIASSEEVSSAIVYDRQGQTLASWHRESTGPLHLLEQQLAHWLLSAPTEQPILHDGQKIGSVEVKGSGGSLLRFLLTGFAGMVLCLLLTALGAFYLSRRLVRGIVGPLDQLAKVAHTVRRERDFEKRVPEAGIAELSQLGEDFNALLDELESWQARLQDENASLAHQAHHDSLTSLPNRAFFEGRLSRALRDANEHREQLAVLFIDSDRFKEINDRLGHAAGDTVLVNIAMRIRGQLRESDLVARLGGDEFAVLLAPLASGADALRIADNIIASMQAPIRLSDGSTVSTSLTIGIALYPEHADTPAALLHDADMAMYIAKRQARGSRRLAELNDPRILQEEKEIDSATPEAPPK
The following text describes a protein:
Function:
Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vincristine, quinine, and strychnine) biosynthesis pathway. Catalyzes the conversion of cis-trans-nepetalactol (iridodial) into 7-deoxyloganetic acid. Also converts iridotrial into 7-deoxyloganetic acid.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATITFDSLNPVTVAISAGFLLLLIIFVKSRTGSSKRKPPGPPGWPIFGNMFDLGDLPHQTLYKLKSKYGPIVWLQLGSINTMVVQNAVSAAELFKKHDVPFCDRKVPDTLTAFNFNQGSLGMNTYGGHWRVLRRLCSMEFLVNKRMNETTDLRRRIEDNMVRWIEEDSLASKAQGGTGAVQLSRFLFLMAFNLVGNLMLSRDLMDNKDPEGREFFDCMNEILELAGTPNIADFLPLLKKLDPLGMKKRMVDNMSRTMKISSKFVQERLDNRKAGKINEKKDFLDVMLEYQGDGKDGPDKFTEQHVNIVIMEMFFAGSETTSISIEWGFTELLRNPHAFKKVREEIDRVVGVNRMVEETDMENLPYLQAVVKETLRLHPALPMLLPRNTMEDTEYMGYLIPKGTQVFVNAWAIGRDPEYWQDPLSFKPERFINSSVEYKGQHFELIPFGSGRRICVGFPLAHRVVHLTLATLVQAFDWDLGAGVKPQDIDLEERLGLTLRKKNPLNVIPKKRVHI
The following text describes a protein:
Function:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITWLSATGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSETHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVEL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MGDVNSLSYKIINDESIIRFTKSSIYNDIIEFITNLNKSVVGVEMKPLEDFKLCNENDMINNDNFLFLSKNVYNIFQLIKNMNKCIDSCPPINQSSRFGNRGFQHFCDAYYKEVDEYLPHALSESNIPNISEHTYQISYYLKNSIGNKKRIDYGTGHELNFLLFLFCLNKINFFIPSDYKHLVLVLYRQYLEGVRRVQIIYTVEPAGSRGAWGLDDFQFLVFLFGAAQLSYNRKIKTDDIEKKELLELWAPKYLYFDALKYISMIKHAPFHESSQMLYDISGVETWEKICNGLLKMYQAEIIQKRQILQHILFGNLIDF