lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Subcellular Localization:
Nucleus speckle. Cytoplasm. Nucleus.
Domain:
The Gln- and His-rich domain may mediate protein-protein interactions.
Sequence:
MEGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRAKVSQRSGILQPRVASTKLYNLLQWDRNPHAITYRQDWSRAAHLYSKNQQSFYLQPVDIPTGHPQQQQQQQFHNHHQQKQQFHDHHQQQQQQQFHDHHQQKQQFHDHQQQQQQFHDHHHHQQQQQFHDHQQQQQQLHNHHHQQQQQFHDYPQQQQQFHDHPQQKQQFHDRPQQQQQFHDHHQQQQQFHDHHHQQQQQQFHDQQLTYLLTADITGEHTPYQEHLSKALWLAVS
The following text describes a protein:
Function:
May play a role in mediating neutrophil activation and chemotaxis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP
The following text describes a protein:
Function:
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.
Subcellular Localization:
Nucleus.
Sequence:
MFYFHCPPHLEGSPPFGAHSASEFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGSCDQEGAKETAPEVITAGRNISPPSTVEPVRGKKETLEAHQRCLSHDRDVGSATSFFPSCLPGSLLNTASYAQALSHVASLKGSPLCSCCVSDPLGLSFLPPYSCQSHRTASVAALRMKAREHSEAVLQSAQLLPTAGNSTGASASAPLEGGPEQQAEQNDTEKNV
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAVVALGANVLSAKSIICDIEGTTTSISFVKDTLFPYALKHVEGYLKNNWNEEATKTVVTALREQAEEDKKAEVEGVVPIPTGDSEDIIPEIVKNVEWQMSLDRKTGSLKTLQGLVWAKGYKDGSIKGHVYDDVQKAFEQWTENGRKIYIYSSGSVDAQKLLFEHSEQGDLLKYLSGHYDTKIGAKREKESYTSILKNIESSPEEALFLTDVYAEAKAAKEAGLNVVLLDRPGNSELSEEERKDFPVIATFSDLSFAAETKEENGGATNGKRKIEETNDDVAEEDKAQVYPNKK
The following text describes a protein:
Function:
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Sequence:
MKINNSYILLKDICCFAYHGVAPQENIIGNEYIINLKLKVDISQAIQTDDVVDTVNYAEIHEAVKAEMSIPSKLLEHVCGRIAKRLLAEFPAIEEIELRLSKRNPPMGADIDSAGVELHCSR
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MCAYFRASNKPLLMARSGIVFKDTTVKVTTEKLPKSLIALQIEIDRDQFERSLDQAARRLSQKFPIQGFRPGKAPRFIIERTFGREALIEEATEELINTGYRKAIKQENIEVVGPPNLDKIHSIEPFVFTVHVPVPPTVTLPDYRSIHVPLEVEPITDEMVEAALEQIREKHLTLQELDEPRPAQQGDQLQVRLKTEIEGEEEEATEEQSEEAADDSEAKAETAADTEQTDDEEEEEEDDEIENEGSEETLPLEPNRLVPELYEGLIGTSVGEKKTIVAVLPEDHHEESLRGKKITFHVEILDIKRRIVPAWEELPALESFNGTFEEFRAHVRENLANQERKRAEQEQLNAYIEQLVEQTTFDIPDVMIRDVAHSMLHEQEQQFARYGITLDQVLQYRGVTHDQAVEELIPEAEKQVKVTLALSEVIKQEGITVGEDEIEAEIQTILESYDEKQRPQVERTLRGQLRSSVANVVLDKKLRARLSAIASGNSTDTSDSSPAAPDAEGATDVTNSDEPVSRSSNEA
The following text describes a protein:
Function:
Catalyzes the formation of the second messenger cAMP.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target; MISCELLANEOUS: Binds 1 C18:1 fatty acid per monomer.
Domain:
Consists of 3 structural domains. The pH-responsive N-terminus inhibits the adenylyl cyclase (AC) activity of the C-terminal catalytic domain. The length of the linker segment (aa 192-206) is decisive for regulation.
Sequence:
MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP
The following text describes a protein:
Function:
Plays an important role in the biosynthesis of the phospholipid phosphatidylcholine. Catalyzes the formation of CDP-choline.
Sequence:
MSNVTGDPTGDLPSTAVALPGSTAVQSSPPTDRPVRVYADGIYDLFHFGHARSLEQAKKSFPNTYLLVGCCNDETTHKYKGRTVMAAEERYESLRHCKWVDEVIPDAPWVINQEFLDNNRIDYVAHDSLPYADTSGAGKDVYEFVKKVGRFKETMRTEGISTSDIIMRIVKDYNQYVMRNLDRGYSREDLGEKRLRVNMRLKKLQERVKEQQEKVGEKIQTVKMLRNEWVENADRWVAGFLEIFEEGCHKMGTAIRDSIQERLIKQIPRKKLENGQDDDTDDQFYEEYFDHDMGSDEDEDEKYYDEEEELEEEKKENAVKTDAKDK
The following text describes a protein:
Function:
Probable acetyltransferase.
Subcellular Localization:
Membrane.
Sequence:
MPFINESQLSVREMREEEAPVVLEMLKDGFKDTENRLILYILTRPMTLLLMAIASSGLRFFLNSFCVALVIPVLLTIVGLKLLLWRSPDLKQIYSYYSIGQRKIWVAVYDQDDICGCVALEPTQDSQSVELKRMSVSRWYRRSGVGTHLLKFFEGHAKKKGFQCIVLYTSVVAKAATGLFMKCGYKVTDGWNWLGYTIVQEFRKDI
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSVSAIFGARVVTIPSVLRTSSVDGRTVKLQPSTGGSCGGGVITIECSSRPQKKGTAHHMKTRPKKTARWDIKRGPAVYPPLPPLPAEWTIVSSAVDEADSSSSTTSSSAEIAQSA
The following text describes a protein:
Function:
Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAYQSQDIIRRSATNGLTPAPQARDFQEEVAKLIDVTTCIGCKACQVACSEWNDIRDTVGNNIGVYDNPNDLSAKSWTVMRFSEVEQNDKLEWLIRKDGCMHCSDPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFDIPRLNPEDNRVYKCTLCVDRVVVGQEPACVKTCPTGAIHFGTKESMKTLASERVAELKTRGYDNAGLYDPAGVGGTHVMYVLHHADKPNLYHGLPENPEISETVKFWKGIWKPLAAVGFAATFAASIFHYVGVGPNRADEEENNLHEEKDEERK
The following text describes a protein:
Function:
Mediates the deactivation of rap1 and plays an important role in spatially and temporally regulating cell adhesion and chemotaxis by controlling attachment disassembly in the leading edge through the regulation of myosin II assembly and disassembly. Overexpression leads to defective chemotaxis.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Note=Translocates to the cell cortex in response to chemoattractant stimulation and localizes to the leading edge of chemotaxing cells via an F-actin-dependent pathway. Cortical localization is negatively regulated by ctx.
Sequence:
MSIYHGIIGSSDHIQNIFPPPSPRKNISLSTNNISSLTTPKNFTAIVVTKPLSQSTTSTQEMMNTSDILFDIQQPLSPQHHSRQIQQQQHEKITPEEEERRSDELQKILLDTIPILIKGVETLGIEVEQICNGDSANEKRSNCQVLVDIQKTLREYPRGMGYRSKTIPSNIVGKPKLIAFRHSMDQLVWENISKLSILKDFVEFTLDFQKLCVIGISIRDAINSFVNNKCEYLIKGFEFNNTNSILSGINIHHHLNHQPGASTPRPSHSSSSSLSHSLSSSPMSQSLPSSLTSGGVSLLNTSDDAIVPSLSSGNDDSSGSSLSSSDANVISINISTVIQNGVRDEINNTSISALKKSQKQQPVVLSRAPKQVMESTRILVDTVVNRKCMYREEKASIYREMMNDRLTLLKEDPKKFKQQLLQQRRQKLTNSDQPHETDYNEDFNLNNNSTNNNNNIKKESNGSSVNSQTTTTTTTTNNNNNNISPQHSGTSGSPSDKENSPIFSPGYLSTSPPKSPPKSPEFLGVPIGKKAHLLGHARSFSADTHATKEAAANQHHHSHNNIGSVLSPPLSSQNERILRNYKLLSSSPSSSSSAVVTNPVSLTTQLQQQQQQQQQQQTTSQPTQPPPSEYQLLDLEWEEPIDSDFILPCKGYKIDSGNSKCQQVNYDELIVLYTDEDEYHYCDDFCSLEHFNFLGVNKNQPDNPMCISVVVQHDTNELLYIIRTGEKDEKYRLSLPYGKKEISSKDMLKMIKKSRFNQMSNFKLKEVKSDQNQQFIKQLIQFEAKNIHKTFKFGVLYCSENQGTDENELYSNSSTSDEFQEFLRILGDRVQLQGWTKYRGGLDIKDNTTGTHSIYKKWRDFEIMYHVAPMIPCRAADEQSVERKRHLGNDIVLIIYKEGNTKLFDPSIIKSNFNHIFAVVQKVDPIPNVDGAAVINLGNSFNNNNSSNNNNNNNNNNNNNNNSDSNLPTTNNLPIITNVNYKISIGCKEEVQNFGPAFPKNHIFSTSTGENLTDFLLTRLINGERATLKSPVFAQKLKRTRKEFLHSFITDFGSE
The following text describes a protein:
Function:
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death.
Subcellular Localization:
Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 T3SS), and delivered into the host cytoplasm.
Domain:
The LRR (leucine-rich repeat) domain forms a slightly curved solenoid and may mediate interaction with target proteins.
Sequence:
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAYADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKDAVNYELIWSEWVKEAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVDYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTSLEEEDVNQWRAFEAEANAAAFSGFLDYLGDTQNTRHPDFKEQVSAWLMRLAEDSALRETVFIIAMNATISCEDRVTLAYHQMQEATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEVEVFLGFQNQLRESLSLTTMTRDMRFYNVSGITESDLDEAEIRIKMAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRDECIETDEYQSRVNAELEDLRIADDSDAERTTEVQMDAERAIGIKIMEEINQTLFTEIMENILLKKEVSSLMSAYWR
The following text describes a protein:
Function:
Transcription factor that functions as a master developmental regulator controlling midline development of the ventral nerve cord. Required to correctly specify the formation of the central brain complex, which controls walking behavior. Also required for correct patterning of the embryonic genital disk and anal pad anlage. Plays a role in synapse development.
Subcellular Localization:
Nucleus.
Sequence:
MTNHRRVRKDCYESRLHDIAKTCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQHLMEQQHLQYQYATW
The following text describes a protein:
Function:
Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield the 15-cis-phytoene isomer.
Sequence:
MNNPSLLNHAVETMAVGSKSFATASKLFDAKTRRSVLMLYAWCRHCDDVIDDQTLGFQARQPALQTPEQRLMQLEMKTRQAYAGSQMHEPAFAAFQEVAMAHDIAPAYAFDHLEGFAMDVREAQYSQLDDTLRYCYHVAGVVGLMMAQIMGVRDNATLDRACDLGLAFQLTNIARDIVDDAHAGRCYLPASWLEHEGLNKENYAAPENRQALSRIARRLVQEAEPYYLSATAGLAGLPLRSAWAIATAKQVYRKIGVKVEQAGQQAWDQRQSTTTPEKLTLLLAASGQALTSRMRAHPPRPAHLWQRPL
The following text describes a protein:
Function:
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network.
Sequence:
MSLFQSALDFLAGPGGSGGAASRDQNDFVGQVVELGELKLRIKRVIAEGGFAFVYEAQDLGSSKDYALKRLLSNEEEKNKAIIQEVCFMKKLSGHPNVVQFCSAASISKEESDTGQAEFLILTELCRGQLVDFVKKVEQKGPMSCDTVLKIFYQSCRAVQHMHKQSPAVIHRDLKIENLLISHQGTIKLCDFGSATTLAHYPDYSWSAHKRSMVEDEITRNTTPAYRTPEMIDLYSNYPINEKQDIWALGCILYLLCFKQHPFEEGAKLQIVNGKYSIPQNDTKYTVFHQLIRSMLKINPEERLSINELVNQLQEIAAARNVNPKSPITELLEQNGGFGNNSAQLPSQINNIHNSGVYDTDPTMGGGFLDILKGGTERFLTNIKDTSSKVIQSVASYAKGDLDLSYITSRLAVMSFPAEGVESAIKNNIEDVRLFLDSRHAGHYAVYNLSKRSYRPARFHNRVSECGWQPRRAPTLKNLYSICKNMHQWLKQDQRNICIVHCLDGRAASAVVVCAFLCFCRLFSTAEAAVYMFSMKRCPPGISASHKRYIEYMCDMMAEEPIIPHSKPITIRSVAMTPVPLFNKQRNGCRPFCEVYVGDERVATTSQEYDRMRDFKMEDGRAEIPLNITVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNASTVKFAKYDLDACDIQEKYPDLFQVHVNVEVEPQDRPSNKTPPWENFATKGLNPKILFSSRDEQQEILTKFGKPELPRQPGSTACYASDPPQSENSPDDPQTESDSPSPQSTDTNANNFFQTLDWEDTSRHFDHADGHLDDQEDLSGGSEEESVSYSAPIEGTLSRDTSEPLFEADFTNTPPEAQPDTEDLLGLNSEPGPAVPESGLKSSASNSNLLNDLLFAPQTNTVPSASNEDLMGEDAGEDLFFSNSSSQPPPATNKDFFDPFGVGSASSGSDLFGDLLGSDAANSGFKAPAPASNSSLFNLNKLASETPKMTSSASQPDLLSGWDSWATSGTSTTANLSTAANKPSMSASGVSSFSKAKSQSFDPFADLGNLGSTLPGSSSASFSGSGFKTAPSAGGPKNSGQQWQQTPRPSSGPNKPWMPPNSTARPQAVPQAAKPNYNPSFSVIGGRQERGIRGPGFGPKPKVKEDDFEDLLCTQGFGSKPDRKMPRTIAEMRKQELSKDMDPLKLQILDWIEGKERNIRALLSTLHTVLWEGETRWRPINMADLVTPDQVKRVYRKAVLVVHPDKATGQPYEQYAKMIFMELSDAWSEFENQGSKALF
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNGEYDYEDGAQHQDGARESAVAGASNTNQISTSFFPPPPQVYKKFTKRNLRYLEILNSHKLADDEPSWDLLSVTQRLERQNAILRQPGSSSKIDAEQLQDEEADMAAIQDQDCDKPMTDLPDFDLKAELEPPNVDWIEEDGGYTVFGQLWPIPDVTPTLQQLGIPVLYPLEGTDRKELLLTLLRTLLQTYREITGDLLKPAQPYDVWVPAVPDPNLTPEQQQQQMATNPGFWTQTTEAKDRLKHMQNVVVNMQFLINELRPVQAKETLKLIMQMQLERRKQEMQLIQERCATMRARVEELKKMLGKQSDCYGSS
The following text describes a protein:
Function:
Probable phospholipase.
Subcellular Localization:
Secreted.
Sequence:
MKIINSFVFIFVLLFVFNTNAIKLSEDEKYSIEEKPEWYSIDSNFAVSPGKISDALGWGYYKNEILKDGWGKLYVEMNKFMTPENSSIYYEATGYLEGYLTWSTTWNYSQAYFQNYMNGTNESDIPTPLVEFLKINYDWMTSTFSNRDESVYDTQVSNVIYQFEGFARGYQQAADSDKQLTTLQLLLLQYAGDLEDVAGYLEYEMAQNKTEYINRVKSLKEIETLFAVKGRCSGLVRITPDYGELFISHTTWGSYFTAGYRIFKRIIIPDPTVPGNEILFASYAGVLTSDDDFFMIPSTEMVIIETTNDILNTSLYQYVTPNSLLYFVRSIIANRLSNTAQEWTNNFIQYNSGTYSNQWMIVDYKLFTPYQPLQPNTFWIIEQLPGGFMSADMTEVLALGNWPSFNRPFFPEIYDAMGYSYYEKLYGDIISYDLNPRSKMFRRDVPNVMSLDGMQQIMTQNNYKSDPFSGGFPGNAIAARYDLGGGPAEPLSWSFIGLHGAIDSKITSYSLLQQNQAIAINGMTVTPDCPPFTWNSNWSTVSAHYGSPETFDFDWISITITDK
The following text describes a protein:
Function:
Acts as a non-essential component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec72 may be involved in signal peptide recognition for a defined subset of leader peptides, or may increase the efficiency of unusual or 'difficult' secretory precursors to the translocation pore, it may be that this protein binds charged leader peptides to the membrane until they engage the translocation apparatus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVAKQESVVAPQVDVSKWSGKELELGKKVNEYAKSLATFKYPFFIPPPYPPAKPNMALSTQVNKMKQTANEAFKRKKYEEAKKLYGLALQLALNRCTWEPSILTREEASVMLCNRAAAEIALSQFPEALADANAALKIRNNYGKCYYRKAKALEAMHRIEEAKQVVRDGLILAEPVTRNELVALWASYTEKD
The following text describes a protein:
Function:
May be involved in BMP2-induced transcription; May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAEETPVSSEKLVVYSEAHSDTILANFEEQRKRGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMLADTFGILLEFIYTGYLHASEKSTEQILATAQFLKVYDLVNAYTDYQSNHSSTNPTTLTTGGTPVVVISNKKNDDPPKRKRGRPRKVKNMQVTKPEIVSLEDIQLRENNSVQNKQNSMAKTVEGSTSITNEQNQIREIEESERACGSSAVEMPAEEDENCDPKSQDVQGSQSRYSKRRIQRSVKLKDYKLVGDEDDQYSAKRISGRRKRSGSEARCKECGKVFKYNHFLAIHQRSHTGERPFKCSECGKGFAQKHSLQVHTRMHTGERPYTCTICSKALTTKHSLLEHMSLHTGQKSFTCDQCGKYFSQKRQLKSHYRVHTGHSLPECNHCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCGICGKSFSDSSAKRRHCILHTGKKPFSCPECNLQFARLDNLKAHLKIHSKEKPFPEAPSAPSSSNPEEVRNILQLQQYQLSTSGEQEIQLLVTDSVHNINFMPSHSQGISIVTAEGTQSMAADQAADLTVLTQQPEHLQSLILSAQPDQTEHIQSLNMMDSQIETSPAEQVHIITLSKETLEHLHAH
The following text describes a protein:
Function:
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADVELKVQEVVTGRDGPSVLTGLRWLFYLVTPEETSFRTLDEVPRYIGQVTPIFFGMVFLEMLVAFLKNRQTNTRLNDSISSISAGMIMTMGDLFYMGAYMMAYVWVYENYRLVDLPWDSPVTWWTAFILAEFSFYWLHRMSHEVNILWAAHQVHHSSEDYNLTTALRQSTTQKVGTFFFAHLPLALLIPPAAFSVHRQLNLLYQFWIHTELVTSLGPLEYVLNTPSHHRVHHGRNPYCIDKNYGGVLIVFDRLFGTFAKEEEKVVYGLTHPLNTWDPIWVQLCHYVHIWKTFWATPGWTNKLSVLWKGPGWALGKPRLGCIEDIPKVKYHEPKYDSKVSWLWSTYVAVHFVLALVLHQELFSVVKTLTTAAMVGRVLFVMWTLVCVAAIMDRKPSAPIVDFTRCLAFVLVDVTARLSGSPVVLLPSPLLNALSAWYLMSAVIWGIKFLKSVFTTKTLKSG
The following text describes a protein:
Function:
Flagellar protein involved in sperm flagellum axoneme organization and function.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MTFYMSFFPHFLYVLESKTNLHTSMTEEEGVEQEQVENPKAYLTPDYFYDDQKLFDESPAKTEFDTNFNLYNIFSFDLSRRYNAIPINETTVVITVGNFAMIYDLATGEEQKIYGHNKGVNCCAVHPNKEYIAFGEAGKDPMLLIYQYPSMKLFRVLKGGTEQAYTCMNFSPDGTMLAAVGTFPDYMLTVWDWERETLILRAKAFSQDVYRVVFSENLKGRLCTSGVGHIRLWEMAKTFTGLKLQGEIGKFGNIEISDTSGFAMFPDGKVLSGSESGSLLLWEDAFIKCEFVRTGGKRCHKDMIELVYHQGQNVITAGRDGAIRVWDFQTIDTAETEDTSVAIDLTQKAKLHISNNSSIKCMYPVGTEWLVVDEKQGIWRADIEGRKAELLQKSHSGAIRALSFSPSGALFITGGDDGFVRLWDITEKKMLSELHFEAAVTKILWINENENDVVFAGFADGCLRIILATANGLTLKQPLKPHTGAIRDIQQSPTSKLVATTGDDGALFFMRFDNLTLEPLGFVYVNGKKPKTKEEITQEAISGKKIEDDKEYARGLRIRWGNMISVECSDGKIATIASPTTFPEDSTESYFIDLPVETIDKGAADENITASFTVDEMTEIKGTKEGQIIFGNLTKNIHSAPVTSIALSPDKVWLATASETGELFLFKESQVQGRNLPKQELKAVEVAPVEDIQGTGYSIEEEKQKSELDRRIKAAEQQKSLIRKEIETLRQKFAALVTQNSKAPKYMQLDDAAFKIDPFLFDLMEEQAVNLEKEASRNTMFAAEKSRVHFRKVKSRLVGDMTEESFTVTSTDGKKEVSSFRITELDPVVLEVIQQSTPNEQPSDEEGETQETEAVAQADTESTISESSNKEQEVQQQKPTKANKFGRQPPLKKVVHTPDEHTRKREKRDRRRKKIMEQKPPANYSDPQDLKEIEIAKRTIGDYKLKDDPSYIAPENERVNATKKRRQLMMLLKAIQDLKLGFNQKLKDLAELKKSLQKSVDETNRQLLEIRGTIGYDPLNPELIRIHENRFEPLVLDEKVNITIPTPEAISFAEQVAAAARRRNEAQAGKQKQAAQPAHRQNAKRKQQAPAKKKKSQDEAPKFTEIEQIEMNELSAELAFKRKMLISNISKAIAKFNAKVDEIAVEKVHAQTEVVLAELRFILMLREFKLLSKLELKDAELNGKLRAKASEMKAISNEVAAHNKQIAQKTHEIEENEKEVKGFLKQFHEIVNPTHKFHDPLLRIFNFNMRKNQDKANADEEEVDLTQLDVDAIKKMFEKQNAEKEEDICPQGCDPALFEQVLDLREKRMDFQDKISEAQNAKEKIQRQIDTIQFKTKNLQTVYQQIKQEFEEFQHEKQRHLNELNFSLSIQFHQIKNLIAKEIPQGEARPPLIVKSMPTDLSDSLIFTESGLKQLADQEVKLRTDRESAHKLFEADVSSFKADKDTLDSSMKQLEERQEKLAGIQRLKFGEPVDLVELEQMKVNKDADAVRAQTKEIETEQNAEMEEINKQIKDMTAQLTQEIQRNTAVLGSLVQLTEQRRDIEAVLQNSRKTATADDLSQDLELTDPNELLQEVEKNNDIIEQLEEEIGLLKRR
The following text describes a protein:
Function:
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor; Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Nucleus.
Sequence:
MEDRRVRSTERCDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHTLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPASNPPPPSLMSTTQSRPPWMNSGPSENRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGTPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN
The following text describes a protein:
Function:
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Binds G3P.
Subcellular Localization:
Periplasm.
Sequence:
MERAIVISALRCLQVVATAAAFTFTAQANAATDIAWWHAMSGELGRQLEKLVADFNASQSDYRIVPAYKGNYTETVTAAIFAFRSRSQPAIVQVNEVATATMTAAKGAIYPVFSLMRDQGEPFSLNDYLPAVSGYYTDAAGNLLSFPFNSSTPILYYNKTMFRDAGLDPEAPPKTWPELGAIAKRLRDRGAPCGFTTSWPSWIHIENLSAFHNLPLATRTNGFAGLDAELTINNSVVVKHVAQLAEWQKTRLFDYGGRGQSAEPRFQNGECGIFIGSSATRADINANSKFEIGYGMMPYWPEVKDAPQNSIIGGATLWVLRDRPRAEYKGVARFFAYLSQPGVQAAWHQNTGYLPITRAAYELTRAQGFYERNPGSAISFEEITLHPPTSNSKGIRLGSFVLIRGAIEDELEQAFAGQKSAQGALDSAVERGNKLLRQFERASPER
The following text describes a protein:
Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MADQGALALHRAAYDGDLQALQTALRKKDCDVDARDKHGHTALMLAVYRQHEAVAEALLAAGAEIDTKTKDGWPVLCEAIGIGNTPILSRLLDAQVQHDLSETKAKSEEFLQVLAARPDFQLRMHWDVHSWVPLVSKMLPQDEVTLYKRGSELRLDTHLAISPSGIGRGDMTIIIRNDGRDGLMLYHLNHEKRGYYRKQVFDVGHMTPEKRDMMLEDLQTTEQVDVSIDVDHAVCTRALSGIYGFRTERQETIGEYECDVYDLTQVGVVSKHRAEHLTPELRAWRKALIARMKAAHAAGRPAHEGRRNSKCSADGDDVSPEDVPSDSADSDVDEDASAPLDQVARTNHNGDDEEEYPDPPLSSLPRHEAPAITFDEYQASADPPYLGRPFTTKDKRKNHRATLWMHQGFPLTIEHLVTLLEAVAPTDPMIHSMTTFLQQRLPPGFPVKLDIPVFPTVSARVTFHHFEERAIEAELFAIPKDYRLMGVRAVASSTA