lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRVPSLSVLSFLLGTALAAASNFEAGLLSSGKVSLGDWKSAHEKASQFVAKLNTTEKIKLITGSSVTTTNGETFTALDILDGDMGAQAYYYVSAFSLSSALAMTWDKEAMYEQGRAIAAEFYGKGIQMVAGPTSQPLGRTPWGGRLVESFGPDPYLNGIATGLETRAYADVGVIAGAKHFILNEQETNRTGGMGGGGGAPGGGGMGRGAEFSSSVPGGMSPTSSAGAIPSSTSTPGGSGMGGGMAGSSAFSSSSSSGAPYSSNADDKTLHETYLWSFYDAVHSGLGGVMCAMTKVNGTLSCQSSSLLLDILKTELGFPGMVWPDTNGQQDALASAANGLDYGSSSLWSESTIEGYLESNNITEARLNDMAIRNLMGYYYVNLDNGTQPSTAAQDDYVDVRANHAKLIRSHGSKSMVLLKNKNNTLPLYKPHKMAIFGSHARAAVAGPNMQFSVEGSGPTYDGHIATDSGSGQASLPYLITPENALNIKASQDGTMLRWIANDTYSSSTGSALVMQGSSSTSVTPSVSAYSENMDVCLVFINALAGEGADRTELRNTDQDNLINEVADNCDNTVVVINTVGARILDSWIEHENVTAVLYGSLLGQESGNSIVDVLYGDVNPSGRLTYTIAKTESDYNVDICYTAQCNFTEGNYIDYRYFDAYNVTPRYEFGYGLSYTDFAYSNLHIQGPSALSTYPTGQLAVGGYEDLWDTVAKVTVTIRNAGSLDGAEVPQLYISYPDVAKQPVRQLRGFHNVYIKKGQSTKVTFELRRRDISYWDVQHQKWAVAPGTYEAWVGASSRDLRTHGSFVVKTKA
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Miscellaneous:
MISCELLANEOUS: Present with 3550 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFPGVVPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVLLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGEALTSFNDMIVEKNITNATVHISIPPCMTGVTLFGELNYGVYGINYDKTENTTLLQEMWPSFDFLITHEPTASQLPFENKTTNHWELVNTTKMFTGFDPTYIKNFVFQERVNVLSLLKQIIFDKTPTVFLKELTANSIVKSDVFFTYKRIKQDEKTD
The following text describes a protein:
Function:
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
Sequence:
MSTITSLLDTDLYKLTMQAAVLQHFPAAQATFLFKNRTPSKQLNDDAIEWLKSEIAALGELRFTEDEIVFLQKHVGFLPAEYFEYLKTCQLDPAAQVKVTVNTEGHLEIEVNGPWKDTILYEIPLLALVSEAYFKFVDKDWSYDGQSELAATKAQELIAQGCAFSEFGTRRRRSLKTHDIVIAGILEGLKSAQGNGIFTGTSNVYLAKKYNLKPIGTVAHEWMMGVAAATGDYSTANLRAMELWIQTVGDANAGVALTDTFGTESFLLDFNKPLTDIYNGVRQDSGDPLEYTKLLGDHYKQLGYEPMSKVIVYSDSLDVEKCGKYKAAAAENGLKAAFGVGTFFTNDFKRLSDGQKSTPLNIVIKIQQLNGQSCIKLSDNLSKNMGDPETVERVKRELGYVEKGDVIDESKRWN
The following text describes a protein:
Function:
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. May act as a stage-specific inhibitor of anf1 in the anterior neural plate during the development.
Subcellular Localization:
Nucleus.
Sequence:
MSTKEEPTKPTLSSFTIQSILQGTTTTTSDRAGRNVARVYTISCQSSSPSISSDEEEQDEFWNGPGCNCPDQGDKDSKGQAPRPCGAHRCPNRTQGSSSSNERLQMPSPSQQGYIEEKQNHYSQSLGDRHKDAGDNMGNSKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVGMPLVFRDNSILRVPVPRSIAFPAPLYYPSSNISLPLYNLYNKMEY
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MEKSAATGEELQLVDPRVWKASAGISSRIAAVGSSVYYFPQGHADQASSLPDFSAVPCPRAYVRCRISSVRLHANRSTDEVFARISLDPRAPPAASPVQPQTEFPFSYSHAAMPTLGGGFSVPRFCAESIFPPLDLGDPTPAQTVTIHDVHGKSWTFRHVYRGTPRRHLLTSGWSNFVNSKRLISGDSLVFMNSSGKVFVGIRRTSRSCGPATLNVEMEEKHGRFSRMPQEAVDAATRVSWTVGMRVRMSVETGDSARMNWFNGSVTKVTINDAGLWRRSPWGMLQVLSLIDSLICESIDTKLYKKQFVVITDMFIEIITWDDPEVLQKVRDVSPWQVECFVAGPQGEIPRSIRNILDEQESSLLPDDKEDSVLTGFKSRIIGSLSPSVSNSSLFPVGMQGARHDFFHTAGLFDSKSNGNQTFLNSVHGVNAPEKSDVPVEPSIRIPSQSRGSSPPRQGSIQALDRETLEPASNQVTKASIQLFGQVIHVGNHIDKDADN
The following text describes a protein:
Function:
Auxiliary factor required, together with HCF244, for the biogenesis of photosystem II (PSII), especially for the synthesis of the reaction center proteins (e.g. D1), via the regulation of the corresponding mRNA (e.g. psbA) translation initiation (ribosomal loading) and stabilization.
Subcellular Localization:
Plastid, chloroplast membrane. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Plastid, chloroplast stroma. Note=Predominantly present at thylakoid membranes.
Sequence:
MVGSIVGSNMAATDARFLSSNFGNSFSINTRIHRFHDRSQIVIPRAQSSSSPSPSPPSDKKKTKTRPGTITTKESEETVAKKLDVAPPSPQSPPSPPTLKLDDVNPVGLGRRSRQIFDEVWRKFSGLGQMSRTTRPDEQETLDSLLIREGPMCEFAVPGAQNVTVLVVGATSRIGRIVVRKLMLRGYTVKALVRKQDEEVMSMLPRSVDIVVGDVGEPSTLKSAVESCSKIIYCATARSTITADLTRVDHLGVYNLTKAFQDYNNRLAQLRAGKSSKSKLLLAKFKSAESLDGWEIRQGTYFQDTTASKYDGGMDAKFEFTETERAEFSGYVFTRGGYVELSKKLSLPLGTTLDRYEGLVLSVGGNGRSYVVILEAGPSSDMSQSKQYFARISTKAGFCRVRVPFSAFRPVNPEDPPLDPFLVHTLTIRFEPKRQRPVDGLAGAQQDLRSFSLVFEYIKALPAGQETDFILVSCTGSGVEANRREQVLKAKRAGEDSLRRSGLGYTIIRPGPLKEEPGGQRALIFDQGNRISQGISCADVADICVKALHDSTARNKSFDVCHEYVAEQGIELYELVAHLPDKANNYLTPALSVLEKNT
The following text describes a protein:
Function:
Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
Sequence:
MSAKLSESDLNDFIGAQVACVKPTRTLHTADEGDEALEVGKEPQEATKVSISLQDCLACAGCITSSEEILLSRQSHGVFLEAWRSLAPKALAVSVAPQSRLSLAQHFGLSVAELDQCLSGVLGSYFGAKYVVGTQLGRELSVQQTNARLVERKQQGVQGPLLCSVCPGFVLYAEKTKPGLVPYMLDVKSPQQITGALLHAADPNIYHLSLMPCFDKKLEAAREDCAREVDCVLTPREFVALLDELQLDLHSFAGAAVPIAQLTPPGWDPRVSWCSSAGSSSGGYAYQYILHMQRLHPGSTIATQAGRNADLLEHRLLAPSGVLLASAGELYGFRNIQNLVRKLLSPATKRSAKVVRRRLPQASPAPPATDPCNADFIEVMACPSGCINGGGLLNGGLGPSQRRDLVSQLNEGYARLPTLDIPMPTYSQPSYIYNLRPLAPTDDVLTVANAW
The following text describes a protein:
Function:
Catalyzes DD-carboxypeptidase and transpeptidation reactions.
Subcellular Localization:
Secreted. Membrane raft. Note=May be anchored in the membrane via a C-terminal amphipathic alpha helix. Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Sequence:
MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKILADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVSPKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAGYALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity).
Sequence:
MATVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHGLLKVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGNGTNQASQTEAEISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLTDGAKGMTISDDYDKTEKERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENIIKDVQKNRPLLLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVSKNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDESEEDNYVSSAGQRGGQRVVQRGIPRAVAGDEDDEDDVNIDDI
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of guanosine, producing xanthosine and ammonia. Deaminates exclusively guanosine and 2'-deoxyguanosine but no other aminated purines, pyrimidines, or pterines. Deamination of guanosine by GSDA is the only source of xanthosine production in Arabidopsis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes predominantly to the nucleus.
Sequence:
MEEAKVEAKDGTISVASAFSGHQQAVHDSDHKFLTQAVEEAYKGVDCGDGGPFGAVIVHNNEVVASCHNMVLKYTDPTAHAEVTAIREACKKLNKIELSECEIYASCEPCPMCFGAIHLSRLKRLVYGAKAEAAIAIGFDDFIADALRGTGVYQKSSLEIKKADGNGAAIAEQVFQNTKEKFRLY
The following text describes a protein:
Function:
Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.
Sequence:
MFKTCLGIVLLISCDGLLAQNVSNSFNWGVEHCGYALGLVMNKLNLLDHHIIEKEVQMESKLNDLSSKIDSLMQQKCNTTTLPVFNKTKDDVYSSCRKTPATGVYTIQPEKPFKEPITVLCDQEYESGGWIVIQHRFDGSTNFYRNWKEYKNGFGNLDGEFWLGLDRIYQLTVSQPYELVVLLEDFDDNKTFARYDQFEIADENQMYMLSKIEGFSGPAGDSLGNVKGMKFSTLDSDNDTWKDSCAVTYTGAWWYSACHASNLNGQYLRGETTEYATGMVWKTFRGYYHSLKMAKMMIRPKWLRA
The following text describes a protein:
Function:
RNA-binding protein which is required for syntaxin location in sensory neurons during long-term synaptic facilitation. Binds to syntaxin mRNA and is required to maintain its accumulation at the axon hillock following neuronal stimulation and at the opposite pole in stable unstimulated sensory neurons.
Subcellular Localization:
Perikaryon. Cell projection. Note=Present in both the perikaryon and neurites of sensory neurons. In unstimulated sensory neurons, located in the region of the perikaryon opposite the axon hillock. After neuronal stimulation, expressed at highest levels at the axon hillock.
Sequence:
MSHNHMMNNQQQHAAMINPGAVASVSGAQVQQRSMMSQQRGGSHAINSSKSPYQLQTSSISQFSHLQQQQQQQQQQQLVNNYHKQKQMSPDITSHQFSSSTGGGMPTQNGNYQSMSGSSIHTSMGLDNGQLSLQHQHHQYSSQPAQALQTSVQQHHYQSQQMTQQQQQAAQQQPQQQYQSFQQQHHLIQQQQQQQQIHTQQQQQLPQQAMHQQQQHLQLHQHLQQRSLNQQQQQQQRYQKQQQQPQPKQILQHSPTSGKSLSSAPHGTSVQPSTLLNHHQHNMAAPQVTPVTNGESAGEDTSPKDSPQAPKTSGRDSVHVSDNEESASNASEMQQSLANTKEKTPMCLINELARFNKMSHQYTLVDEQGPAHKKTFYVKLKLGDEEYSASGESIKKAQHAAAAIALVETKCPHPPPKPARLGCCDLEKSADGNITPTVELNALAMKRGEPALYKSIEPQQPPYYHQPNMDFRGLYNQRYHQYMRASRDPRYRGNGVLWPLRYHYPRMNRAFYVSLRVGHREFIGDGPTRQAARHNAAQKALRILKNLPVQSGEKKSEEQADEAAEDACEEDVDDSLKSEISLVHEIALRRNMVVQFEVIRETGPPHMKNFLTRCTVADMVTEGEGNSKKTSKKKAAELMLEELRKLPPLATPAFPRPKSKIQMNKKKNRNLIKSELQQQKADPNYGVGINPISRLIQIMQAQKKKEPVYTLVTERGLPRRREFIVQVEVEDKTCPGSGPNKKLAKRAAAEAMLQLLGYTKPSPQPTKSSFKNPSTGEAGQTNGDKKVTFVGGDSPGDGDDKVSSGSNQQRVPGLLHLPSKSSASSSGNQHTASKESLVNLASILKPNLRPEIQLRELCKAMDCQLEIDDFTKKRTSGTEHITRITIGSENPQSFHGSNTSLESSRDMAALDALKVLVARAKDIHPGGDGPQVKKDVLARSGSGMKKDFSK
The following text describes a protein:
Function:
Extracellular metalloprotease that contributes to pathogenicity; Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MMNVNGRIVAGISVICMVLCGIAAGQEEPPVRYDGYQLWRVIPRSDVDLEVLTLLCDKHNLSFWLEPSSVGRPVDVMVSPSSAEKLTAYFKRYFSSFEVLQTDIQRVITEQYMDRARPGLEFEYEQYHNLDEINAWMDTMVSKHADLATKIAIGTSYEGRTISALKISVPAQASRYHSNRTNAGKPSIFIQGGIHAREWISPATVVYMTNQLLKQYKTSDDVKRILTAFDWYVLPVFNVDGYVFTWTTNRMWRKTRSPTSNPLCKGTDPNRNWDNHWCENGASRNPCSETYCGKSAFSEVEVVAVSSFLSSGINFVGFIDFHSYSQLWMTPYGYTYSLPKTSDYFKQNTQSEKSVQALEGVHGTRYEYGTISNTLYTASGASVDWTYDDAGILYSATVELRDMGQYGFLLPANQIIPTGEETFAGLTQYALYILKNQ
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MGVAALGPQRLRLRPSALHLESRGAVEPAFSLSFPGCGVMLNWQLGVLKGLSRHVDPMEVPLLGSSSGALTAALGGCGVGPEAAAEELLRLMCEQRVAQRRLGLIGRLGSLTRTWLDRVLPDNAGALLSRGRTTVLVTQLPRLQTQHISAFGDKQDVVEVVMASAHLPLVLDGSWYATCRSAPAIDGGLWWWWRRCEAAYTVPAGRGGSSSSSGSSGSSGSGSSGSSSYSRTSAEGLQEQGEEGEEGWVRASGGLASGGAGAAAAAAAVAGDGGGGGSSGAVGVALSSPTSFLDFIAGDVQRGLAPEVARQQRQRAAAAAAHSWSFSSAGGLVRGSSSGSSNYGIGSSSGSSNYGIGSSSIGGGGGGGGGFLGEDASTLPWAAAVGGAGSPLPAHSHTFPLLPRLHPHPHPHPHHTAHTHHHPHHPHHPHGAMGLALAAAGPGGGVAAAASGNGAGSGGRMSATLAAQQQQWHMQDLAWEPYGGGSSSSSSGGSSSSSSSRQPVVLIVQPGDDPAVVAEWGRFRNWRPSSPSSSPTRSTRSTHSGPGSGSGSYADARELLRRGEAYGAGPLLRRIEAGLKEAAAAAAAAN
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (By similarity). Exhibits catalytic activity for the formation of hydroxyestrogens from 17beta-estradiol (E2), namely 2- and 4-hydroxy E2. Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (By similarity). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system. Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (By similarity). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (By similarity). Plays an important role in retinal vascular development. Under ambient/hyperoxic O2 conditions, promotes angiogenesis and capillary morphogenesis of retinal endothelial cells and pericytes, likely by metabolizing the oxygenated products symptomatic of oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion. Note=Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria.
Sequence:
MATSLSADSPQQLSSLSTQQTTLLLLFSVLAAVHLGQWLLRQWQRKPWSSPPGPFPWPLIGNAAAVGQASHLYFARLARRYGDVFQIRLGSCPVVVLNGESAIHQALVQQGSIFADRPPFASFRVVSGGRSLAFGHYSEHWKTQRRSAYSTMRAFSTRHPRSRGLLEGHALAEARELVAVLVRRCAGGAFLDPTQPVIVAVANVMSAVCFGCRYNHDDAEFLELLSHNEEFGRTVGAGSLVDVLPWLQLFPNPVRTTFRKFEQLNRNFSNFVLDKFLRHRESLVPGAAPRDMTDAFILSAEKKASGAPGDDSSGLDLEDVPATITDIFGASQDTLSTALLWLLILFTRYPDVQARVQAELDQVVGRDRLPCMSDQPNLPYVMAFLYESMRFSSFLPVTIPHATTANTFVLGYYIPKNTVVFVNQWSVNHDPAKWPNPEDFDPARFLDKDGFINKALASSVMIFSVGKRRCIGEELSKMLLFLFISILAHQCNFKANQNESSNMSFSYGLTIKPKSFRIHVSLRESMELLDNAVKKLQTEEGCK
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MTVDGEPQRDLNQARRIVLEMKEPLCRIPEDLRSLLSVTISVYCIETPSALVSTIIKNMPPEASIALVTGCRFLAVRDGPRGKTVTVLSTAFLSGLDESVTQQLFIHADTLLLTPEARSRISLLQDIIEDPPTSFETVGHIAHYNLREAHLPYRYFIGAVTCEKEPAITTVITKIDTVQSQYRTYNFELIGGVPRYDVKLVQDGITYSFNYTKVYWNSRLSHEHLSLAQHINQTICPNDLVLDGTCGIGPHALLLAKRFNFTNLICNDLNPDAYKSLKMNVRINKAENAITCFNEDVSSLLRRLLPETNLKAVIFSLPELSINLLQAMKGVPDIYCFLECFTRAPPHLAYYDLLLRCSESLLDTKVCTGIQQALSDIEKVAENKELIDLLIACYETFEVKEIRTVSTNKFMYRVTLKINEQKETVKVLKK
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MASRDEKRIWYDGVIPYVIDCSLSELMKVFFTMKEWESKTCVRFVEREGEDDYLTIFRGTHCYSTVGRAKGKRIMSVGNGCEYHHVMLHELGHVIGFWHEQSRPDRDEYVRVLWHNIAKGWENAFLKLSWEAVDTMRVHYDFSSIMHYPFDAFSRNNKRTLLPLIPVKATPYTKLTDRDVLKVNLMYKCSTICRDKLYSCKLWAKQGFCEIRKDFMPTECPKSCKICQDKNERTTTSMPVCKDRTSWCRKWASYGYCHTKAVYMLKSCKRSCGICEDPRDPSLPCEDKHKSCVYWASIGVCDVRPTYMYKHCRLACRVCTPGIKHEGPPCDNKDPDEECDHWAKLGKCASRPSYMMEKCQKSCNACPPSK
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MSSWKQVTCDQRGVPMLIDEIITKQYPNFSLTIPRIRYGEIGVLTLTNKRLIFNVYQNPIALEFDLSELGQFTTAAHPADANALAFSKFKSASGEDFSMQALKFDLTDLAARLSTSQSSSSGSSKRIVKKISTKSASREFRGIAAAKQIEQNDIDQKNAQLSSSLADIQSLKESAQQLLNFAQELKRKGDSDSKSDLDEVYAALGVTDSTIEKSGGQFSERLALRFATDISKVLEVKGGVLSVAEAFCIFNRKLGTDYVSPNDLADAIKHLQRRQYKVKVETIEGVTVVILANKTYQAVLTDILSKIDEGEYTTPLLMSKKTGLPMSIARNYLLHAEVDGVFCRDDSMAGLRFYKNNFKNFKPMSY
The following text describes a protein:
Function:
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MWTFLGIATFTYFYKKCGDFVSLANKELLLGVLVFLSLGLVLSYRCRYRNGALLGRQQSGSQFAVFSDILSALPLIGFFWAKSPTGSEKKEQLGSRRGKKGSNISETTLVGAAASPLISSQNDPEIIIVGSGVLGSALAAVLSRDGRKVTVIERDLKEPDRILGEYLQPGGCHVLKDLGLEDTMEGIDAQVVDGYIIHDQESKSEVQIPFPLSENNHVQSGRAFRHGRFIMGLRKAAMAEPNAKFIEGTVLQLLEEEDVVLGVQYRDKETGDIKELHAPLTIVADGLFSKFRKNLISNKVSVSSHFVGFLMENAPQFKANHAELVLANPSPVLIYQISPSETRVLVDIRGEMPRNLREYMIENIYPQLPDHLKEPFLEASQNSHLRSMPASFLPSSPVNKRGVLLLGDAHNMRHPLTGGGMTVAFNDIKLWRKLLKGIPDLYDDAAILQAKKSFYWTRKMSHSFVVNVLAQALYELFSATDDSLYQLRKACFFYFKLGGECISGPVALISVLSPNPLVLIGHFFAVAVYATYFCFKSEPWITKPRAIFSSGAVLYRACSVLFPLIYSEIKYLVH
The following text describes a protein:
Function:
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
Subcellular Localization:
Secreted. Note=Secreted upon association with IL12B.
Sequence:
MLGSRAVLLLLLLLWPRTAQARAVPGGSSPAWAQCQQLSQKLCTLAWSAHPPMGHVDLPREEGDAETTNDVPHIQCEDGCDPEGLRDNSQPCLQRIHQGLVFYEKLLGSDIFTGEPSLLPNGPVDQLHASLLGLRQLLQPEGHHWETEQIPSPSPSQPWQRLLLRPKILRSLQAFVAVAARVFAHGAATLTP
The following text describes a protein:
Function:
Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAQGAAHKRFRNAVHRVALLQAVTKRFIHRAEEALGCTFWGDVGVPRFASGDASYNEEAMKEQETSKKGKRKNKGSLSFDSSLFKSQYEFTFPEKAIEVALRRPEQRSEQDIRFIRSMMMGILSFRRYSSQMQLMLARVVYYRRFGRGRVIVRKGHRGDSFYFVFSGVIAVTQDVDGSSALLDPEPILLHKGASFGEVALLKDLRRNATVVCMEETEFLVVDRMEFFENKLDQELQKELKYRFQHFRSLDLFSSWSDKSLETLADHCKAEECHHSQVMVKDTHETKNIIFVTKGRCEVLRLVHLSQCPSFLKWIKQHEAHTGKPILGPHHSEIGKSHRGSRFHGTSFSQREEPNLTAQNGDISDKRPPSMEDRAIHRVLTDASGNLDLPRSLMAGVYLRIDTIHPGQYFRGVDVDYIESCLERDSRPIHEPSLTCLSNLYHKDPRSMVIISQGAEVIRVKLDKFSELSDLVTLKKLKEDILPYPSDNELCRIFLEQNRWKIFKEDLVTTLSSAPSPSHNVYPKRNRSRTEAGHKSHTADRRGILQLGRGKPSNIKIWTTPVMENVSDPGTEQDQSPIRLIHGIDIPKLCGKRIMW
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLYHALLLACCLAALTLPSGGMGAGDLFTSSANIYQLYSVEKNLASDLETLINDHQVKLDHLRLVVQQLRDAPQPADDLHLSPKESFSVIERLVADRVHNLTSHDMIPSDEDLAGASAALLRLQRTYEMGPDSLMPNASVSAYHRIGRQAYKQGDYASAIDWLAQAADLTQSAKERAEILDYLAFSHFQVGDLQAALDRSAQLLELQPDNGRVFKNVEYYTHQLHKASNGTSASGSVRVARKANYRPDNVLGRDERELLKFNKLCQGRKIYKPSKPLSCRLQHFNKPHLFLKPIRVEYVHEGNNRLQIFRNFASAQECAHLREEGRKKLSRAVAWTDGAFRPVEFRISTAAWLQPDHDDVVTNLHTRIADATQLDLEFAEALQVSNYGIGGFYETHYDHHASRERELPEGDRIATFMIYLNQVEQGGYTAFPRLGAAVEPGHGDAVFWYNLLPDGESDNNTLHGACPVLQGSKWVANKWIHEKKNDICRPLA
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MALPLSAIKAVLSSDELHVGLEDVVFDFALEWAHAKYPNLGERREILGSHIVPAIRFSSMSTHKLRAVFECEDIDPSLASKLVARAFIVNAEEAELKHCVAECAYKLPPLKVIQLAESLAKCLVFLDLRQEQCAALFPTGYMKSQVFYLSGNAFYLRVQCNKNDESSSHSFGLYLGIGERLDTVFTQYTFAYRLKPSRRFRTTGMLEYQFVKGQTSEYGFANLFKTPWTSFIAGDSPHFLNGLLHLRAEVAINTQ
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFIVSSTALSSHLQAISRVINSKNALPILDCFLFELEDGTLSVTVSDSETTMVTTVEVNESDTNGRFAVVAKTLLDALKEIPEQPLTFYVNTDNYEITVQYQNGKYSLMGQNADEFPQSAVLGENAVRVEMEAGVLLGGINRSVFATADDELRPVMNGIYFDITTEDITMVASDGHKLVRCKTLAAKGNERAAFILPKKPATLLKNLLPKEQGTVTIEFDERNAVFMLESYRMVCRLIEGRYPNYNSVIPQNNPHKVTVDRQQLIGALRRVSIFSSQASSLIKLRMQENQIVISAQDIDFSTSAEETQVCQYSGAAMSIGFKSTFLIDILNNISADEVVIELADPSRAGVIVPVEQEENEDLLMLLMPMMLND
The following text describes a protein:
Function:
Channel-forming protein essential for import of protein precursors into mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MADHLALPSFLTDNSVVSALLDTYTSFSERRAALGLPNPGTVENVGREVQKDVLLSNFMFSGLRADLTKMFSMAPLFRVSHAFSMGGSGNMAPYAFSAMYGTSSVFMQGNFGSDGGLAALYNYRWTPKLVTKTNVQIMPGAEQGLIQLDNDYTGDDFSLSLKAFNPSYLDGGLTGIFVGSYLQSVTPKLALGFEAIWQRQGLNTRPESAVSYSARYKSDDWIASAQLQAQGVFTASYWKKISERVEAGVDMNLQFAPNAAAMMMGGPSKDGTTAIGAKYDFRASTFRAQVDSAGKVSCLLEKRIAMPIALTFAGEIDQAKQSAKVGLAVSLEIAGEEVMEQTEKADPSTMVTPPF