lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
GDGHAADKPTPPPPPRPVLLAGASGDAKLCRAAALSREEVIRRRRRGLLQLHSLYRAQLWALADELSARHAEYWWEHGSSPDAGNAVGGGAPPPPHPAVNGGGAAVEIAAARAGCSAANCGAKAMPFAAYCFDHILFDPKQLLYKPCAFVTNRSGMQNGVETCGKPVLTGITPSRCSDHDPKSQRLVIEALKKVGIDLHLTSNGVPKLNLLICETVRQIQRKRKMQLNGAKNAPFHRSSD
The following text describes a protein:
Function:
Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSFSLNFTLPANTTSSPVTGGKETDCGPSLGLAAGIPLLVATALLVALLFTLIHRRRSSIEAMEESDRPCEISEIDDNPKISENPRRSPTHEKNTMGAQEAHIYVKTIAGSEEPVRDRYRPTIEMERRRGLWWLVPRLSLE
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSTSGEKWETVSHKKKATVADKKAAQKAFVQHAPTVDQMSPLRENSTMFSEAFTNGSAKGAKKANGDASQGGKKPNPTPQQHKKKKGGSDGKKKPERFNTLDEALDALQVAEVKDQLEEVKARVPDSPALWLGDLALLLNRKLLTKEFDPTFPDKPSDYPLCKMNSSVRKLLKNLMETYPERMLSMFFQHCIREVETDLPKGNAVNGYRIFLQLLAVEYPQFVTNRISDYLEVFKRRQSDRATCLTILWGCIQAGQHDPVIGLQVWSKLMLPLLGHKMVSPYAISTLDRFLGQKLDEKRASQVLGPNEFFPILDYVFTPNNSLQPNLQKQLLGHYPRLKRLAFRENPESNLRNFFPSLLARTTDHCPVALKTELLECLVFCLCQDQHCFSEWRQMYDSHMKQSSLLMNHIIKVWDQVKLPKKLLQETVRAFSVTNEEQLALNQASIRRVHIEECKVACEELLEKMSSFRMPWKTLISVVFLAIMTFLAMDFYTSHGFQGSRTEVFLQKSGLLAISKQAWTKISLFTTNIMGWLQVNAPIYYAKVSELCGPYLALALEKLYDLWAWFVTVTTPLKDWIAVNAPIWLDWILAQTVEILQRLMVWLTQLWEVVSEYAIAGWIVVAPYLQQAWDLTVVYVALVWNAVYPVLDQAWDMLKTTFSKT
The following text describes a protein:
Function:
Probable zinc protease.
Sequence:
MHPLPASRWLAALLLALLIVASPITARSTRSGPLQRIARTSNIKVERIPRSEHLHLQARSDTGSSLRLSFRAFQQDFHLHLQPNEHMLHPDGTRVRYFGVNETTGESYVESSETLYPGDVPAYHGVVVHSSFSPRRLEEDRAGVARDIYQDHDLGVVGRAAIMLHDDGLVSGAPSFSGSFDWFGNVHYIETPRSYIAKRQAQDPWLESRSSSSGSMVVHRDSDITLEPRDDTFTTNFTASMACSSDVLDYNSHNRLVLSDDTNDASSLSVYSFFKSPIPARLSRRELSSGWNDLFARSIQDDIVETPQASSDAFIYHKALDDYLEPTFQRRQATGNDIGNGNNQTNSFENVIGSTAGCPRSARVVYAGVASDCAYTERFGTQDDTRREILNNMNSVSNLYRSTFNVSIGVVELDVRSASCPSSATQDAPWNLGCGTITIDERLSDFSRWRSQQPGNGIGLWHLMTACNSGREIGVAWLGTVCMTDASSSSGQTVSGTGVSSLTTQQWQVMAHEMGHNFGAIHDCTNGCTSNSNFAVQNGGAPCCPLSATTCNANAQYIMNPSSSSNIQSFSQCSIGNICSLLGQGLDTSCIQTPGQRSTLSTQQCGNGILEPGEECDAGPNGSQCCTSQCRLASGAQCDPATSACCSNSCTFAPSSQMCRPAVDERCDSAEYCTGTSAECPADVTKDDGSSCGSRLSCANGYCTSRDLQCQQASTGQLNFQTACSASNANSCQLTCQSPNSANSCLILQQPFIDGTSCGYGGRCKGGECKSGSWQNTFRSLYMDNLRISIPVTIVVGIIVLLILFSIVRRCCCGGRRQRPAKSSGRRPFQRSHGNDYNGAAYNVPIPEGTPQGSQSSSQVQGAYAAPSFPPPPPMRQSYSSYGNGATQPSGWVDPAAYNGPHRS
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs. Has glycosylase and nicking activities and is active at A/G and A/GO sites.
Sequence:
MSDSNHSLDLHSYTQLEVERFRESLIQFYDKTKRILPWRKKECIPPSEDSPLEDWEQPVQRLYEVLVSEIMLQQTRVETVKRYYTKWMETLPTLKSCAEAEYNTQVMPLWSGMGFYTRCKRLHQACQHLAKLHPSEIPRTGDEWAKGIPGVGPYTAGAVLSIAWKQPTGIVDGNVIRVLSRALAIHSDCSKGKANALIWKLANELVDPVRPGDFNQALMELGAITCTPQSPRCSVCPISEICKAYQEQNVIRDGNTIKYDIEDVPCNICITDIPSKEDLQNWVVARYPVHPAKTKQREERALVVIFQKTDPSTKEKFFLIRKRPSAGLLAGLWDFPTIEFGQESWPKDMDAEFQKSIAQWISNDSRSLIKKYQSRGRYLHIFSHIRKTSHVFYAIASPDIVTNEDFFWISQSDLEHVGMCELGLKNYRAALEIKKRKVTSLSNFKEPKLTSARRIVTKAEC
The following text describes a protein:
Function:
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
Subcellular Localization:
Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.
Domain:
The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).
Sequence:
MYSGAGPALAPPAPPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLWLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA
The following text describes a protein:
Function:
Transcriptional regulator that negatively regulates transcription of the mce4 operon, which is involved in cholesterol transport and utilization. Acts by binding to the promoter region of the mce4 operon. It affects the utilization of host cholesterol as a carbon source, impacting the host's innate immune response.
Miscellaneous:
MISCELLANEOUS: Overexpression of the gene in M.smegmatis impairs the utilization of cholesterol as the sole carbon source by M.smegmatis, activates the host's innate immune response and triggers cell apoptosis.
Sequence:
MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLTMRLGRDRRQDLVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTTVAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVRGRTAGPPA
The following text describes a protein:
Function:
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.
Subcellular Localization:
Secreted.
Sequence:
MAGPAMLVAAALALCLLLASPGLAWYKPTAGQGYYSVGRAAGLLSGFHRSPYARRSEPRGGTRSLGGVGTFREMRPNLRSLAVCVEEVTPNLQSCEPLPDGRATFQCKADVFLSLSASDCRK
The following text describes a protein:
Function:
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase (By similarity).
Sequence:
MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPKKPKVEEEDTGDPFGFDSDDESLPVSSKNLAQGKGSSYSESSEAAQLEEVTSVFEANSKCSHVVGEDSFASDRCLLVEDTLIGKEKSISRIPEDNANKSSCTKLLTSDKVENFSEEHEKNSHHFHKNAEDSTKKPNAETAVASEYKADETKETNDTWNSQSGKRTESPSESCPVKGSVRTGLYEWDNDFEDIRSEDCILSLDNESLLEMKDEDLKNRIGGLENLNETFEEDIIQSVLRPSNCRTYCRANKARSSQGASNFDKLMDGTSQSLAKANSESSKDGLNQAKKGSASCGTSFRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHDETGGDEGGSGSSNYKIKYFGFDDLSESEDDDDDDCQVERKKDKKRTKTAPSPSQQPPPESSDNSQDSQSSTNNAENLDFTEDLPGVPESVKKPISKQGDKSKENTRKIFSGPKRSPTKAVYNARHWNHPDSEELPGPPIAKPQRVTVRLSSKEPNQKDDGVFKAPAPPLKVIKTVTIPTQPYQEIVTALKCRKEDKELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDDEDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIISSAKALQHCEDLIQQYNRAENSICVADSNPLPYQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQEGLIGTAMNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMQTSCSFDSSFSSGEGDHSLRLAGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGAEEKQKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKFLSFMNLTCAVGTTGQKSISRVIEYLEHC
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MALPRPTSPHARGSNRTPAIMRLVLGACVPGLLTLTWLYGPGTLLNLAWASLVALACEAAMLALRKRPPGVFLKDGSALVTALLLAVALPPYAPWWLTLVATFFALVFGKHLYGGLGQNPFNPAMLGYVVALVSFPLEMTRWPSPDSALGLPDSLREFLGLATRPDAWAHATALDVLKTDRSLTVDELFAGNPAFGHLGSAGSEWVNLAFLLGGLFLLWRRLFTWHAPLGMLAGLFAMSLLFWNGSGSDSHGSPLFHLFSGATMLGAFFIVTDPVSGATSNRGRLVFGLGVGVLTYVIRAWGGYPDGVAFAVLLMNLAAPTIDYYTRPRTYGHRKAERGFKAGD
The following text describes a protein:
Function:
Required for maturation of 30S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPRDIVEQVTALAEPVAEQLGLQLVAVAYQTHTKPATLRVDIRHPTEGTGLDDCEKMSRALEALLDTRDDLIIGAYNLEVSSPGVERVLTTDREFMAFRGFPVMVKTFGPVDGKKQWEGRLLERDGENVYLTIAGRRVALPRPQVARVQLVQSLP
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MDALQGDLFHPTPGAVTADHSGGIMPDPPWREWVTPHKISLLILISEYVQSKAERSQGITDVFTKTLLFGVRLQRNFSLALLKWIQSPDETLADLRREVEKLAEGDPSTAETVVGWLDNKLKEMAQDGLMVLTDFMQSLEQLFNLSAEGEEPLLQRAGVVGMFIRRMVLAFDKLSFSQVSSLYELLMEYCQEGKSSVRDNLDTSDAMEMADEGEGMRREDLEVGKEDSTILSYRQAQYYLSLGLQNNYNDAEASSPAELQQQVQRLLKSNPLFVEAHYLSYLNSMNVYEWCGAVQSLHLYFDRFSLHSQHNQQSKPNEDAMAARSYRYAALNLASLHCRFGHREEAMAVLQEAIRLAQVTNDNVCLQHALIWLSRLEQDESKVAMLLQRSVIRASVLTLPYLASMAVQMFTKLKAQAGLKPARVFEYLAKSNSLNCLHYIPELVASCFALQTALWQMYGKSAMSLLNIQLLLHGSGNPTTNHWDKELGCLVLSHLAVIHADQGNYTCVYEILQLLKEKFHHIKKNARVWMFAEQCINFDRALRNHKWTAAETAITSLAALDNTEAQYRRALLLKEKGDSVGACKHLQELLQKCREEPSTTITEIHAGVLLALGEVYTAASNLTTANSYFLQCLTLCKEHHLNHMATMAQLNIAHIQLLMKLPTQALALTEQVMPQVLSHGSLYNRSRAQFLLAKCQLASSDPKHPTQRKAAILSAIGTLGIALEGFQKVEAPARVKDVLYYQAQLYNEVGNSADRNRCALQFRQLDQQVPTNPTQILNIF
The following text describes a protein:
Function:
Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. Catalyzes the oxidation of cyclo(L-Leu-L-Leu) (cLL) to yield pulcherriminic acid which forms pulcherrimin via a nonenzymic reaction with Fe(3+). Substrates with small alkyl groups (cAA, cLG, cLP) exhibit weaker binding to CYP134A1, but substrates with larger hydrophobic side chains bind in a similar regime to cLL.
Sequence:
MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFISRYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSGVADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYTRGPVSLLVAFDGA
The following text describes a protein:
Function:
Regulatory subunit of the error prone DNA polymerase zeta. Involved in damage-tolerance mechanisms through translesion DNA synthesis (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSRKDDNQSGEVGRTLVDFMEVAITMIVYLKGFYPSAAFERRRYMNVVVQRARHPELRDYIHSAASGLLPFIEKGLVERVAVVFFSEDNVPVERFIFKITIKPSCAALVEEGQLEFALRSFLIKLSVSKSLVKPLPLNCRWEVTAYLRSLPQVGSSKEAELWIPTDTKQWQNPPVLTPVKSLNSEPLCLQLYLEHPSLSEPLNLVNPEDVAPHDP
The following text describes a protein:
Function:
May play an important role in the development of cancers in a broad range of tissues.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the cytosol and the Golgi apparatus.
Sequence:
MGSTDSKLNFRKAVIQLTTKTQPVEATDDAFWDQFWADTATSVQDVFALVPAAEIRAVREESPSNLATLCYKAVEKLVQGAESGCHSEKEKQIVLNCSRLLTRVLPYIFEDPDWRGFFWSTVPGAGRGGQGEEDDEHARPLAESLLLAIADLLFCPDFTVQSHRRSTVDSAEDVHSLDSCEYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAMYLPPAPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSASSASPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLFFVLKSSDVLDILVPILFFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSIRVPMDIPVFTGTHADLLIVVFHKIITSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLFSAAQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRSIFHQLANLPTDPPTIHKALQRRRRTPEPLSRTGSQEGTSMEGSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVSEDGTLRSLEPEPQQSLEDGSPAKGEPSQAWREQRRPSTSSASGQWSPTPEWVLSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPVWYDTDVKLFEIQRV
The following text describes a protein:
Function:
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Membrane; Peripheral membrane protein.
Sequence:
MATAKFFSFACLRNESSNYGELSPKPHYPSMPKYPKGVSVSSDEEKSIHGTESKAVFSVNGMSCSACAGSVEKAIKRLPGIKEAVVDVLNNKAQVIFYPSFVNEEMIRETIEDVGFQATLIIEETNEKTSQVCRIRIKGMTCTSCSTTVESAFLLIPGVQKAQVALATEEAEIQYDPRILTYSRLLEAIEDTGFEAILISTGEDRSKILLKVDGVYTEDSMRIIESSLRALPGVEDIDIDLELKKLSVSYKSDIIGPRNFIQVIESTGSGRFKAMIFPEGDGKQSHRQEEIEHYRHSFLWSLVFTIPVFLTSMVFMYIPGLKDGLDIKVVNMLSIGEILRWVLSTPVQFIIGRHFYSGSYKALRHGSANMDVLIALGTNAAYFYSVYSVLRAATSPSFKSTDFFETSSMLISFILLGKYLEVLAKGKTSEAIAKLMNLAPETATLLQFDDEGNVVKEEEIDSRLIRKNDVIRILPGAKVACDGFVIWGQSHVNESMITGESRPVAKRKGDTVIGGTVNENGVLHIRATKVGSESALSQIVQLVESAQMAKAPVQKFADRISKYFVPLVIILSFSTWLAWYLSGKYNSYPISWIPSSMDSFQLALQFGISVMVIACPCALGLATPTAVMVGTGVGASRGVLIKGGQALESAQKVNCIVFDKTGTLTMGKPVIVNTKLFRSMVLREFYELVAAAEVNSEHPLAKAIVEYAKKFREDEENSVWPEAKDFESITGHGVKAVVHNKKVIVGNKRLMLEQGISVPVDADEVLAEAEELAQTGILVSIDGVLIGVVAISDPVKPGAREVISLLKSLNVESKLVTGDNWGTANAIAKEVGICDVIAEAKPEDKAEKVKELQSLGNIVAMVGDGINDSPALVAADVGMAIGAGTDIAIEAADIVLMKSNLEDVITAIDLSRKTFGRIRLNYFWAFGYNLLGIPIAAGALFPFTGFRLPPWVAGAAMAASSVSVVCSSLLLKNYRRPKRLDNLEIGGITVES
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MNEDQVSLENQTNPVSPEASDVPAVTPEESPQPTDAVLGEPSGEQSEDPRIGAATETEGGPLEQEKSSEEIIAILQKDLASHRQELAEQSEQLDSIKKRYVALAAEFDNFRKRTQREKEEQAKLIKGRTITELLPVVDNFERARTQIKPNSDGENQIHKSYQGVYKNLVDSLKGLGVAPMRPEGKPFDPKYHEAMLREPTAEYPEDTVIEELVRGYLLDDIVLRHSMVKVAVAPEEGAEVVNGEAGANP
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLTVPPLIPRLLLALTPLATIAAAFFYFSQTNVLQPTPYIDEIFHIPQTQQYCKGHWNAWDSKITTPPGLYIIGYAWARMLTLTGLSESEACSTLSLRAVNLMAVVIYIPATLYIIQRRVWGSQAHFSAFSLVSFPLIWFYAALYYTDVWSTATVLMALAFALSPRVPFYMVQLSALMCAVSLFFRQTNILWAAVVAVIAIENSHYSNGAPPKNGALAQIFSTISYTFQIELPIFNILISYASVAVGFSFFLYINGGIALGDKDNHVAGNHIPQVFYCALFITTLGFPVWFTWAHLKAYISSSFSVLGLTVRPLFIFVLIPRLLKSYAIEHPFLLADNRHYVFYLWRRLLKPAIYSISVEDVMQSQDAIDPKTLDVISIGLKYALSAAIYFSLWNIWTTLTNSIPAAILVRGRGFNRRNGKSISPAIDLQCLTWPILLAMVFATLASLIPSPLIEPRYYILPYLFWRIYMTPTTAGKRVNTDARFLREWIWYMLINAATVYMFLYKPFEWAHEPGVLQRFMW
The following text describes a protein:
Function:
Contributes to the transport of fatty acids and their derivatives (acyl CoAs) across the peroxisomal membrane. Provides acetate to the glyoxylate cycle in developing seedlings. Involved in pollen tube elongation, ovule fertilization, and seeds germination after imbibition (controls the switch between the opposing developmental programs of dormancy and germination), probably by promoting beta-oxidation of storage lipids during gluconeogenesis. Required for biosynthesis of jasmonic acid and conversion of indole butyric acid to indole acetic acid. Confers sensitivity to monofluoroacetic acid (FAc), a toxic acetate analog, and to 2,4-dichlorophenoxybutyric acid (2,4-DB) and indole-3-butyric acid (IBA), two precursors of auxin after beta-oxidation.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein. Glyoxysome membrane; Multi-pass membrane protein.
Sequence:
MPSLQLLQLTERGRGLVASRRKSILLAAGIVAAGGTAVYLKSRVASRRPDSSRLCNGQSDDDETLEKLTATDQNAKITTKKKKGGGLKSLQVLTAILLSQMGKMGARDLLALVATVVFRTALSNRLAKVQGFLFRAAFLRRAPLFLRLISENIMLCFMLSTLHSTSKYITGALSLRFRKILTKIIHSHYFENMVYYKISHVDGRITHPEQRIASDVPRFSSELSDLILDDLTAVTDGILYAWRLCSYASPKYIFWILAYVLGAGTAIRNFSPSFGKLMSKEQQLEGEYRQLHSRLRTHSESIAFYGGETREESHIQQKFKNLVSHMSHVLHDHWWFGMIQDFLLKYLGATVAVILIIEPFFSGHLRPDDSTLGRAEMLSNIRYHTSVIISLFQALGTLSISSRRLNRLSGYADRIHELMAVSRELSGDDKSSFQRNRSRNYLSEANYVEFSDVKVVTPTGNVLVEDLTLRVEQGSNLLITGPNGSGKSSLFRVLGGLWPLVSGHIVKPGVGSDLNKEIFYVPQRPYMAVGTLRDQLIYPLTSGQESELLTEIGMVELLKNVDLEYLLDRYQPEKEVNWGDELSLGEQQRLGMARLFYHKPKFAILDECTSAVTTDMEERFAAKVRAMGTSCITISHRPALVAFHDVVLSLDGEGGWSVHYKRDDSALLTDAEIDSVKSSDTDRQNDAMVVQRAFAAARKESATNSKAQSYQTQLIARSPVVDKSVVLPRFPQPQTSQRALPSRVAAMLNVLIPTIFDKQGAQLLAVACLVVSRTLISDRIASLNGTTVKYVLEQDKAAFVRLIGLSVLQSGASSIIAPSLRHLTQRLALGWRIRLTQHLLRNYLRNNAFYKVFHMSGNSIDADQRLTRDLEKLTADLSGLLTGMVKPSVDILWFTWRMKLLTGQRGVAILYTYMLLGLGFLRRVAPDFGDLAGEEQQLEGKFRFMHERLNTHAESIAFFGGGAREKAMVDKKFRALLDHSLMLLRKKWLYGILDDFVTKQLPNNVTWGLSLLYALEHKGDRALVSTQGELAHALRYLASVVSQSFMAFGDILELHKKFLELSGGINRIFELDEFLDASQSGVTSENQTSRLDSQDLLSFSEVDIITPAQKLMASKLSCEIVSGKSLLVTGPNGSGKTSVFRVLRDIWPTVCGRLTKPSLDIKELGSGNGMFFVPQRPYTCLGTLRDQIIYPLSKEEAEKRAAKLYTSGESSTEAGSILDSHLKTILENVRLVYLLERDVGGWDATTNWEDILSLGEQQRLGMARLFFHRPKFGVLDECTNATSVDVEEQLYRVARDMGVTFITSSQRPALIPFHSLELRLIDGEGNWELRSIEQTTE
The following text describes a protein:
Function:
Involved in the control of root growth angle. Involved in cell elongation in the root tip that causes asymmetric root growth and downward bending of the root in response to gravity.
Miscellaneous:
MISCELLANEOUS: IR64 cultivar shows shallow rooting in an upland field.
Sequence:
MKIFSWVANKISGKQEANRFPANSSAPYRANVSDCRKDEFSDWPQSLLAIGTFGNKQIEEVAQVENSSDNVQSVQDTVKFTEEEVDKIRKEFETLLAIKDQAEAQRSHDDDQVGLQKRADGEDNEKHIRQLINKRIIVSKSKNSLGKKGNTLKPRSVASLLKLFMCKGGFTSVVPEPRNTFPQSRMEKLLKAILQKKIHPQNSSTLVAKRHLDWKPDETEINECLEDALRDLDDDGAKWVKTDSEYIVLEM
The following text describes a protein:
Function:
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDENSLEDFSLDNYDWENWPPCIENDVPADDSFHFTFTDELLFQNASELSSSNEYSASSFESNSSTCFFSSARDYENIDNHQYIYSTEQKTLSCSSSQKHVNISSEQLAKLKFKELKRLFKSLPETKVQELKKKRRQLKNRNYAKTCRHKKITKNVSLEEEVKMLRQERIHYVNEISKYKEEIKLLKMKLEITDRAL
The following text describes a protein:
Function:
May play a role in septum formation.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MLTDPGLRDELDRVAAAVGVRVVHLGGRHPVSRKTWSAAAAVVLDHAAADRCGRLALPRRTHVSVLTGTEAATATWAAAITVGAQHVLRMPEQEGELVRELAEAAESARDDGICGAVVAVIGGRGGAGASLFAVALAQAAADALLVDLDPWAGGIDLLVGGETAPGLRWPDLALQGGRLNWSAVRAALPRPRGISVLSGTRRGYELDAGPVDAVIDAGRRGGVTVVCDLPRRLTDATQAALDAADLVVLVSPCDVRACAAAATMAPVLTAINPNLGLVVRGPSPGGLRAAEVADVAGVPLLASMRAQPRLAEQLEHGGLRLRRRSVLASAARRVLGVLPRAGSGRHGRAA
The following text describes a protein:
Function:
Plays a role in the transport of the nucleocapsids from the cytoplasm toward the host nucleus together with the host actin-polymerizing Arp2/3 complex.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MTNRRYESVQSYLFNNRNNKIDAHQFFERVDTAEAQIIKNNIYDNTVVLNRDVLLNILKLANDVFDNKAYMYVDDSEVSRHYNAVVKMKRLVIGVRDPSLRQSLYNTIAYIERLLNIGTVNDSEITMLIADFYDLYSNYNIELPPPQALPRSRRPSVVQPAAPAPVPTIVREQTKPEQIIPAAPPPPPSPVPNIPAPPPPPPPSMSELPPAPPMPTEPQPAAPLDDRQQLLEAIRNEKNRTRLRPVKPKTAPETSTIVEVPTVLPKETFEPKPPSASPPPPPPPPPPPAPPAPPPMVDLSSAPPPPPLVDLPSEMLPPPAPSLSNVLSELKSGTVRLKPAQKRPQSEIIPKSSTTNLIADVLADTINRRRVAMAKSSSEATSNDEGWDDDDNRPNKANTPDVKYVQALFNVFTSSQLYTNDSDERNTKAHNILNDVEPLLQNKTQTNIDKARLLLQDLASFVALSENPLDSPAIGSEKQPLFETNRNLFYKSIEDLIFKFRYKDAENHLIFALTYHPKDYKFNELLKYVQQLSVNQQRTESSA