lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors.
Subcellular Localization:
Cytoplasm.
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST
The following text describes a protein:
Function:
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MKKFDEINIIPFIDIMLVLLTVVLITASFISQGKIQVNVPKASTAVAFKSDELAKLLTVTADKQLYFNDKPISQEALEAEIAQWNKDQKVTLKIDAEASFQDFVTITDMLSKNEIKNVAIVSMKDKGKSAGKNSQESTPSQSVPTTP
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MENKDALDIGKDDTNTSEADVSKNETQEQPVLSKSALKRLKRQQEWDAGREKRAEMRREKKRLRKEERKRKIEAGEVVKSQKKRIRLGKVVPSSIRIVLDCAFDDLMNDKEINSLCQQVTRCHSANRTALHPVELFATNFGGRLKTRQDFVLKGQQNNWKRYNPTTKSYLEEFESQKEKLVYLSADSDNTITELDEDKIYIIGAIVDKNRYKNLCQNKASEQGIKTAKLPIDEYIKITDRKILTVNQVFEILSLWLEYRDWEKAFMEVIPKRKGILLKSDESFDVSEDTRSQSNQSDSELEKEN
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MASEHAQLSAKAAAGSRFAVTYGLLRQYMKEQGGSGATRSLAPAVGVGLMPEADAAAAAEATEERTTVLELFPQQAGTLKDEQQRCVNSPLPSVSASPCACELLIADLSVVRRPLRKRKERADGRAPLTIFYGGKMVVFDDFPAEKAEELMQLAGSGNAAQDALGQPSLTDMPLARKVSLKRFLEKRKNRLTAADPYPAAAATAAASESSTKPPAVKDEGAPWVGVNSALSLS
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MEERPEAELISIPATPRVSTPEILTPGQRSPRAASKEGKSWTPTSFISPRFLSPIGTPMKRVLVNMKGYLEEVGHLTKLNPQDAWLPITESRNGNAHYAAFHNLNAGVGFQALFLPVAFAYLGWSWGILSLTIAYCWQLYTLWILVQLHEAVPGKRYNRYVELAQAAFGERLGVWLALFPTVYLSAGTATALILIGGETMKLFFQIVCGPTCTSNPLTTVEWYLVFTSLSIVLSQLPNLNSIAGLSLIGAVTAITYSTMVWVLSVSQQRPPSISYEPLSLSQPSASVFLAMNALGIIAFSFRGHNLALEIQSTMPSTFKHPARVPMWKGAKVAYFFIAMCLFPIAIGGFWAYGNQMPPGGILTALYAFHSHDISRGILALAFLLVVFNCLSSFQIYSMPAFDSFEAGYTSRTNRPCSIWVRSGFRVFYGFVSFFIGVALPFLSSLAGLLGGLTLPVTFAYPCFMWVLIKQPPKYSFNWYFNWILGWLGVGFSLAFSIGGIWSIVNDGLKFKFFKPN
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWQAYVDDHLMCEIEGNHLTAAAIIGHDGTVWAQSANFPPVKPEEITAIINDFNEPGTLAPTGLHLGGTKYMVIQGEAGAVIRGKKGAGGVTVKKTGMAIIIGIYDEPMAPGQCNMIVERLGDYLLDQGNLIWCDSISRLVNLLVVLPS
The following text describes a protein:
Function:
May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.
Subcellular Localization:
Nucleus. Note=Associates within the nuclear transcriptional apparatus during proliferation and differentiation.
Sequence:
MFLTEDLITFNLRNFLLFQLWESSFSPGAGGFCTTLPPSFLRVDDRATSSTTDSSRAPSSPRPPGSTSHCGISTRCTERCLCVLPLRTSQVPDVMAPQHDQEKFHDLAYSCLGKSFSMSNQDLYGYSTSSLALGLAWLSWETKKKNVLHLVGLDSL
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP. Required for normal development of the gametophyte and embryo, in association with GK1.
Sequence:
MGEAPAFFVDHLENGYTNGFGVKSEPKNRDTSVLIGDRSFVIGGNHEGNPLFLGVQIHDKVTNKWSSPSVLGTGPKPCKGYSAIVLPKGRILVIKKGSASDDSIWFLEVDTPFIREQKKLLGREVVAWSKGVRGNAEKPIVISGPSGVGKGTLISMLMKEFPSMFGFSVSHTTRAPRCMEKNGVHYHFTDKTVMEKEIKDGKFLEFASVHGNLYGTSIESVEVVTDSGKRCILDIDVQGARSVKASSLDAIFIFVCPPSMKELEDRLRARGTETEEQIQKRLRNADAEIKAGKSSGIFEHKLYNDNLEECYKTLKNLLGINDLAPVNGVEVEGINLPKEHTVTKMDDKILIQETGEGTKNKMIVLDLSSINGGAPGRTRGIVLDTVKSS
The following text describes a protein:
Function:
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MVCVGRFLGTTSACSMHICLLPKWLRGVNHPQSSRGTTCWAEMAALKRSRAQAWPEEQGDREHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDYERGMIRSGRDFLLALERQGRCDETNFRQVLQLLRIITRHDLLPYVTLKRRRAVCPDLVDKYLEETSIRYVTPRAHSTAEHSLGHPHKSVPPQHPMVCCSSAGPQICTKRPGRGRALLSSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYEVGRQKLLRNLMLQTAP
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Sequence:
MCTPYANSPGFAGDDQEEFPYDVEDDVWGPVEPLDEYKRDGFHPIIFGDRLGANGRFRVVSKLGAGGYGTVWLCEDTLSPTLKWRAVKVMSAKASKPDCEELRALEVFRSIDRSILENDFHLSAPLEYFWIDGPNGRHLALVFSLCATTAEHFFANYGHHRTLVKDLCFQLVKSLELMHSRGLCHGDFRPSNIMFRLRDGIDSLPETELLKHMSPPKPARVISIEDEKPVTRASAPSVPEFLSPCTSIPYHSGLCATKLAVTDFGVSYSASNPPVEGFTGIPTRYASPEERFRIRELLSYPSDMWSLGCVISWLAMGFTPFGHEGDGAWMDELSINMEKNMGPMPEPFRAKFREEHDQQTPVEELGKAKSELDFLTEMAKLEFQRHKEQQNVDGKSGRYLHSGWDVWRSRITRSSGTMTSMTAGEVKQMSEQLQNNPSQLPCSELRQPDSKTRRDSDDAMSVTMDEKEIDQLFDLLISIFKWHPKDRATIEQVLNHPWFEGRNWNAAKVPSPVTAKKSVVDEAIESVKSYLYVNVTSRWAQGLS
The following text describes a protein:
Function:
Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation. Inhibits root growth.
Subcellular Localization:
Cell membrane. Secreted, extracellular space, apoplast. Note=The precursor of SCOOP8, PROSCOOP8, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP8 in the apoplasm.
Sequence:
MEEKSASQLGLVVFLLLFLLVPTHTESSLPSQQESLPVIGSSRRLMSTYKTNSNIDFEGSISGQAGGGQQNP
The following text describes a protein:
Function:
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails (By similarity). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar.
Sequence:
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVTALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQSNGAGALSYTSPNTSKCPVTIPDDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLNEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKSHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVPIAVNTSKYAESYRIQTYADYVGKKREEKQMKRKWTEDSWKEVEPKRLNTQCGSYSLQNHHYHANSLTATSTVGKRNLSPSRAEAGLEARASGEISDTELEQTDPCAEPLSEGRKKAKKLKRMKKDLSPTGSISDSSAKLFEVPDTW
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MPRLELSPLRQSDPPLQRKFRSIWLRVKDLPYDALHRYHRLGRKGKASIWILTVINLLIVAVVLIITPTRIGQWFNSLALSIKGMGWKGVVLCNIFAILSSHPPLFGFVPTLTLIGFIYGIWPGFLIAGIASMLGAGIAFLSVRSFFLGLFKKNDKWEAFGHVMRAKGLPLVIMIRFCPVPWGVSNGLFASIESVKFWHFMVANLMIQPKLLLVVFIGSRLTSLASDSAAHDPLRFWLNLISIIVSACISIATGVIIYRLTLQQMRKLDQTGAGLGDGELAAEALEENALLGDYDSGSGEDEAEFLTSSNHRDREGNGKGLKVGGGAGIIRRNSSQDTTGDADLV
The following text describes a protein:
Function:
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous:
MISCELLANEOUS: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MLDSIKDSFTESIQIQIAAAEALPDAIMHAAQAMVASLLNGHKILCCGNGGSSVNAQQFVSCLLNRFETERPSLPGMALTADNTTLTAVANDYHYQEIFSKQVRAFGQPGDILLAISTSGNSKNIIKAMEAAVTRDMTIIALTGKDGGEMAGLLGENDVEIRIPSHRTARIHEVHMVTLHCLCDLIDQVLFPAHEE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MASALASLDQEGLLIVKVERDYIWKEDTVPLEDDIAPERFHERFRQFCYQEVAGPREALSRLRELCRLWLRPEMHTKEQILELLVLEQFLTVLPREIQNWVRERHPESGEEAVAMVEDLQRDPRRLRQQVTLRRQGQQGLLEDAESLNLQPKEEEQRARANQEKGLWSPQSEPQEPSSPKEAQSSLEEELQPLRERASPTPRVPSLSRKGTTRDRDMAVALLSYDSQRSKKYENASMSLSQERQNHLVPPRRNLHRHLKQENYGNISSLGFGVSKPDISGLKPGEEELGDLDLQGSKDKDILRGSCPEEQEETESEAPTRREEANWKDQEPEAWKDEKVAGMHWDSEEIKTLLAILSEPQFYEIIRICHQNSQVYGAVAERLQEYGFLRTPEQCQAKFKGLLKSYRRARSGHVLEPCIFYEEMDALMSSWSPVLPTDVLEEGMSLPYYGMGHAETDEQEPGAWDHEVAAAGVLSEESDSDELGIEEPAQEEGPSSLFQGSRGFEFGNGIKKNPKQEISDEVKLHGTFPGRPKMDAPLHPDWEKAFENECSSGWQWENPQGERQQRLTPQEDLEKVLGFQWPYLGESSFAYLKFGKGFPHSSHLITHQLAHQIKNPHTCSECGKSFDLSRSLIRHQRIHTGEKPYKCLDCGKSFSHSSNLCAHRRIHTGEKPYKCGECGKCFNQSSSLIVHRRIHTGEKPFKCAECGKCFNQSSSLIVHQRTHTGERPYKCGECGKSFNNSSHFSAHWRTHTGEKPYECPQCGKSFNRSSHLTKHWSIHRREKLLLQPRPSYTPEDLQGSSVL
The following text describes a protein:
Function:
Exhibits phosphatidylglycerophosphate phosphatase activity. Involved in root growth and columella cells organization. May possess protein phosphatase activity.
Sequence:
MRIEELPGDSGGGGGGGMVGGGELQPQPQLRCEDGGANGGKLRLRGEDRGVDGGELKLRAEDGGAAVEEGQEESRVEESTGGAVMRAAFDAKRAAVGVGARMLFYPTLVYNVVRNQFESHFHWWDQVDEHVLLGAVPFPSDVLRLQKLGVCGVVTLNESYERLVPKSLYEAHGIENLVLPTRDYLYAPSFDNLCKAADFIHRNASCGKLTYVHCKAGRGRSTTVVLCYLVQYKQMTPAGAFEHVRSCRPRVLLASAQWKAVQEFYQLRVKKTGPSCLDIPIIKPTSSPVFLATQNLITFDDKTFVMVSESDLEGYNADTLSVNVGSSLWEISLVYRVQFASQAAFAGFSYLWLQCRARKDKEALAESVGSESCSLEAEQPANGHPCLLQSVVVNP
The following text describes a protein:
Function:
Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA. RCL1 activates BMS1 by promoting GDP/GTP exchange.
Miscellaneous:
MISCELLANEOUS: Present with 10000 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSSAPKYTTFQGSQNFRLRIVLATLSGKPIKIEKIRSGDLNPGLKDYEVSFLRLIESVTNGSVIEISYTGTTVIYRPGIIVGGASTHICPSSKPVGYFVEPMLYLAPFSKKKFSILFKGITASHNDAGIEAIKWGLMPVMEKFGVRECALHTLKRGSPPLGGGEVHLVVDSLIAQPITMHEIDRPIISSITGVAYSTRVSPSLVNRMIDGAKKVLKNLQCEVNITADVWRGENSGKSPGWGITLVAQSKQKGWSYFAEDIGDAGSIPEELGEKVACQLLEEISKSAAVGRNQLPLAIVYMVIGKEDIGRLRINKEQIDERFIILLRDIKKIFNTEVFLKPVDEADNEDMIATIKGIGFTNTSKKIA
The following text describes a protein:
Function:
Required for respiration. Stabilizes the mitochondrial bicistronic mRNA encoding ATP6 and ATP8, 2 subunits of the proton-translocating ATP synthase.
Miscellaneous:
MISCELLANEOUS: Present with 1760 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNTLRCLTQALSKSGREAPKLYQKVIFPGLFREGIPIANVKKVDEKIIDSPTSTSVNGEAKKIVRHGVKYEREQVKEYLSSLPTLTLSRKQIRDDYDEERAKRMYMFSKQTNSSNKFQKLLTAKSQEFTRELLTLLIDCTSNEKNSGPERFTRKFLKFSNDEIPPLPDFSKNPQLFENYIGILSHTKFNFRSSSKLNGIVRKMLRHLLHPTNKTTLPLRSAQVYNDSIYFFSEHFDFASCREIFAQMKAEGTKPNTITFNLLLRNVVKNSHIRKTKHPDDEVLFYLRSMRNHGVFADVITWTTCYNFLRDEVSRQLYIVQMGEHLGNFNVNFVYTVLRNGDYRAEDCLKVLAANSLPISRKTFYLCIERLLNEEQLETASKLLDYGFQHLKSNFKLDSEAMNHFMRVFANKGRSDLAFLCYNTCRKIYKIKPDSQTFEMLFKALVRNGNTKNFGAVLQYIKDLKVSEGFGLRTSYWRTKADSIFKFGSPNTLSEKSIEKARKLLGNLIASEGEFSWKIWKESDSSQKKILRFLGCIPTTLRCTNTAQDHQKPTNLPSNISQKKREYRNRVKAIATKAALEKRMAYIKDNDVAFKKELVKRRIVGEV
The following text describes a protein:
Function:
Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MASRIMGNTIQQPPQLIDSANIRQEDAFDNNSDIVEDGGPTPFEATLQQGFQCPPATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPLLPPPPPPVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHLKSKHESRKEKRKKSSRHESSRSEERKSHKVPKLEPEGQNRPNERVDPAPEKPREEPVLKEAVPVQPILSSVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREERVEQYTFIYIDKQPEESPSQAKKSVTSKAEVKKPRRPRSVGNSQPEQTSAGEVASPQSSTDPRRQSQRRHTSVEEDGPPPVKIAWRTAAARKSLPASITMHKGSLDLHKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRNEKSTPSASPPEATSGSAGPVEKKQQRRSIRTRSESEKSTEVVSKKKIKKEQVETSPQASLKTGLQKGASEISDSCKPLKKRSRASTDVETASCTYRDTSDSDSRGPSDGQVGFGKQVDSPSAAADADASDAQSVDSSLSRRGVGLSKKDTVCQVCENTGDSLVACEGECCRHFHPECLGLAAVPEGRFTCEECETGQHPCFSCKVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMKCLRCPIAYHFGDACVAAGSVSVSSHILICSNHSKRSSHSAAINVGFCFVCARGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRQVSQADRKWWPAETCSPRSVPLNIQGLKHGVGDFPVLFFGSHDYYWVHQGRVFPYVEGDTNFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKTSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAADEKTKNAKLKKRRRGKAEAKQIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECGSAAISFCEFCPHSFCKAHEKGALVPSALEGRLCCSNHDPASPVSPEYWSKMRCKWESQDGGEEVKE
The following text describes a protein:
Function:
Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MACRGTAGDGHRASATPSRVSPGSLSTCRTHAHNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVIIVTHAYGNRKGIRYLTNGLKVYYLPLKVMYNQSTATTLFHSLPLLRYIFVRERVTIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSITIVVVSRLVYRKDILETKKSTKMKTKISGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRDVLVQGHIFLNTSLTEAFCMAIVEAASCGLQIVSTRVGGIPEVLPEDLIILCEPSVKSLCEGLEKAVLQLKSGTLLAPENIHNIVKTFYTWRNVAERTEKVYDRVSMEAVLPMDKRLDRLISHCGPVTGYIFALLAVFSFLFLVFLRWMTPDSIIDVAVDATGPQGAWTNNYSHSKREGENSEISKTSLPGYLNCNCQCCTGRYVETHCSTLLLTLILK
The following text describes a protein:
Function:
Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol. Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity. Has little or no activity towards glycerophosphocholine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Sequence:
MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRVFSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGIPVLMHDNTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRNDFPDEKIPTLREAVAECLNHNLTIFFDVKGHANKATEALKKMYMEFPQLYNNSVVCSFLPEVIYKMRQTDRDVITALTHRPWSLSHTGDGKPRYDTFWKHFIFVMMDILLDWSMHNILWYLCGISAFLMQKDFVSPAYLKKWSAKGIQVVGWTVNTFDEKSYYESHLGSSYITDSMVEDCEPHF
The following text describes a protein:
Function:
Required for the accumulation of phytic acid in seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Sequence:
MTETTKVMYIVVVDGTDTAETVEEDGTGTWKDSFRYTRPVLQSTLQLMGCKARHAFKISRRVFELIRSEGSLILSPSLSPSHSKESEFQKTGDASACANVEKANKVNSLATDDVDKSKSKPFEVYKRRTTVVVSREIFVNVVCDALAEYKYVGHDQRADLILSCRIRERKESVTVLLCGTSGCGKSTLSALLGSRLGITTVVSTDSIRHMMRSFVDEKQNPLLWASTYHAGEYLDPVAVAESKARRRRAKKMDSIEDEKAKASEGGKAKNTQQTDVGSTKNTPVLLSPKQMAVEGFKAQSEMVIDNLDRLITAWEERKESVIVEGVHLSLNFVMGLMKKHPSIVPFMVYIANEEKHLERFAVRAKYMTLDPEKNKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSVAAIHATVFSCLRRREAGEHLYDATTNTVSVIDDEYRNQCTANSLSSKGMFQLIQRKGSSRHLMALLNTDGTFARTWPVTGKVDESGKPVFCNEMIEENGMEHPVYGYLQKAEPVNLQFGLFGISAWPSDGATSRAGSVDDCKADMAETSSRYYSSCCSSPRMSEGTSKELKEDQSVHGSDEEVEDDPPEPDTDFSDDDNKRDHDEVGSVDEQSTKSDEEYDDLAMEDKSYWTDEEEESRDTIAIMSEKNNKQATKEDKYIQNLDLFLRTANQQLVEPLQLCASLLTCENGNTRLWLGKEKMRKRSLSISAIGKHGSGLGDAILLGAP
The following text describes a protein:
Function:
Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility.
Subcellular Localization:
Chromosome. Note=During meiosis, recruited to chromosomes and localizes on recombination sites in a double-strand break-dependent manner. First appears on the chromosome axis at leptotene. Along with the progression of meiotic recombination, released from the axis to form bridge-like structures linking homolog axes before they are synapsed. Finally, located between synapsed homolog axes and on the synaptonemal complex (SC).
Sequence:
MNKKKQRNSGVGLHPSKPSKNPRLRDSQSSMMVHSHYSRESEDSSEPAPSVELGGEEPLHEAFSCPVEDTGAASDLAGSPKELVPLPPSQNSVGKFVPQFAKPRKTVTRKAKAWEEDLEGCTTSQETRPELGALKAASQPQRESLRFPPHDIRPEVQTQPDGTLSKERTISLDNRSLGNNGFEMATVQDSSSPLSDAAAEGREADSRDPQERDAQGGEAGAQHSGEPQEGEDILYTSALAPASEPTWSVAQDLSVPTYTLSSTAAAPSSTSPADASLMDTVITEVSLDPSVLQQSAPQVAKLLGSLDEQIPDGGCIGTLLSSTPLAEETTAGREEARWEERCHGDTLASFTETEPEKQEPVTEAGDSGHIAQEMDPVVKTKDSGSDEQSPGDIGMLPLPAQSMNQMLVELRGLTCDQDLEGLSTPHTSSQLEHTCAASDPPQSTKDCHSSPGIPVHLAAPCPRDQAAWQESSAMELDFLPDSQIQDALDATNMEQGFPSGSMPDLGWPVPSSQSIGGSPKAVTKPQSRSHVETWAQETYRMQDATDTVRGLVVELSGLNRLIMSTHRDLEAFKRRKTKSLPYLTKGLGSLPRGDQSWRDL
The following text describes a protein:
Function:
Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MARGQQKIQSQQKNAKKQAGQKKKQGHDQKAAAKAALIYTCTVCRTQMPDPKTFKQHFESKHPKTPLPPELADVQA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MPVHGVIYYSSPSMATFLSPAQDNLVRTYFAQHLKKWVVQYKLYRNAVTPKTLEFLKQNINPSMLACVDEATMIDAEPELEDIIVRTKLWNFRQSFTIEGSIYEVGSFKVAIANVLQKSVWKGILFHVTYDGTESVDLARPIIQEFFLKCFLQNNKSVTPVYESFFNQPRHSLDSKLLLQLFKQRIDTVSQRT
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEATTAAQNLILRWDIVATNENLFDGEHRAEAERYLRAVKDIRQSESSSTTSVGIFLEMAMNRLKAEFRKILVTRLDEVDSDFLESSLSSISLSSSVNGLGDSFSVPDPGISVRNSFDDDVDDEEEEDIYRIFEKELATLDVVDDLRSIAKKMIASDHSQECCQVYCDARKDSIHNCLQLLGITKFDLDEILHKPWETVVVMIPQWIHAFKVCLRVFSSEKRLCDLIFDGLDCDRGSNSMSLSEQSFAETAKGPCYQLLRFAEAISTVEKSSEKLFKIIHIYQALRSVLPDVETIFCGPYCSSINSQVSEILSQLKEIIREIFSEFANDIQRYSENLIPGGTVHPITQYVMNYINLISEYKIVLSDIIISAPSMNDDASSNLEVNLDDDDGERSPVAVHLVRIVALLVAKLDSTSDLYKDPGLKQIFITNNIHYVVKKVKATPVLLEMIGRNYIRRLTGRYRSAATNYHRATWVGVLNCLRDEGIRTKSSTFSSGISKTTLRERFKSFNAAFEESHKTQASWIVPDDGLKEELKIMISERLLPAYLSFFGRYHQFIENGRNSHLYIKYTVDTLEKAIQDFFGGGSSSNSTHSLSHGVTQRRGKFFNLGITRSF
The following text describes a protein:
Function:
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNSTGHLQDAPNATSLHVPHSQEGNSTSLQEGLQDLIHTATLVTCTFLLAVIFCLGSYGNFIVFLSFFDPAFRKFRTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIPDAFCFTFHLTSSGFIIMSLKTVAVIALHRLRMVLGKQPNRTASFPCTVLLTLLLWATSFTLATLATLKTSKSHLCLPMSSLIAGKGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVRKCPPVITVDASRPQPFMGVPVQGGGDPIQCAMPALYRNQNYNKLQHVQTRGYTKSPNQLVTPAASRLQLVSAINLSTAKDSKAVVTCVIIVLSVLVCCLPLGISLVQVVLSSNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLQYIGLGFFCCKQKTRLRAMGKGNLEVNRNKSSHHETNSAYMLSPKPQKKFVDQACGPSHSKESMVSPKISAGHQHCGQSSSTPINTRIEPYYSIYNSSPSQEESSPCNLQPVNSFGFANSYIAMHYHTTNDLVQEYDSTSAKQIPVPSV
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MASQEDPVQREIHQDWANREYIEVITSSIKKIADFLNSFDMSCRSRLATLNEKLTALERRIEYIEARVTKGETLT