lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5-formyltetrahydrofolate (5-CHO-THF) to form 5,10-methenyltetrahydrofolate (5,10-CH=THF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT).
Sequence:
MSITSPVSNTWAPTVKGPHGTQSKIDTKSLSPNLSRAELRKQVRLARRSLSTEVQAEASINACERMLKKLMAMNAQHVALYLTHDGELATAPLIAALWQRGIQTYLPRLHPFNAGQLLFLHYHADSPMQPNQYGILEPKLDVRSVMPIERLDVVVTPLVAFDIKGNRMGMGGGYYDRTLANWQDNGKPLPMGYAHDCQQVPSLPCEHWDVPLPAIITPSRVWEF
The following text describes a protein:
Function:
Synthesizes selenophosphate from selenide and ATP.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Nucleus membrane; Peripheral membrane protein.
Sequence:
MDSCVIPLRHGGLSLIQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQKMSEEERDKIMPLIIKGFRDAAEEGGTSVTGGQTVLNPWIIVGGVATVVCQPNEFIMPDSAVPGDVLVLTKPLGTQVAVNAHQWLDNPERWNKIKLVVSREDVELAYQEAMFSMAMLNRTAASLMHTFNAHAATDITGFGILGHAQNMAKQQRSEVSFVIHNLPIIAKMAAISKACGNRSKLLQGTSPETSGGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNQTARIIEKPRIIEVTPRGASASPQDNNSSASPEAAS
The following text describes a protein:
Function:
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).
Sequence:
MDPETCPCPTGGSCTCSDKCKCKGCKCTNCKKSCCSCCPAGCEKCAKDCVCKGEEGAKAEAEKCSCCQ
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MQFTKWFIALPLAVTALSGCSLLERLVYRIDINQGNYVDQQSVDQLKFGMSKDQVRFVLGSPMLVENGYPDTWYYIYHHTQGHNDPVQKNLIVKFNDGGKLVNVAGDFPAGDSFFEGVN
The following text describes a protein:
Function:
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Subcellular Localization:
Nucleus.
Sequence:
MATGLSGQANWSNMVWEVKTKLMPDSVQKVQVLVEESASRMDDTFEMLKCTEDLPSSPGCPSSENRMEYDDLPELQAVQEDRASPAVFQLTTGVSHQERPRNIWGPRPSCPPAGGVSPEHGTSWLAELANIATSPQSPLMQCTFYNRSSPVHIIATSNSLHSYARPPPASSSSEPSLSKTHWKERAAVKHERASSESESGIFCMSSLSDDDDLGWSHSWPSTAWHCFLKGTRLRFHKGNNVEWQDAEDLADSDDESEDERDSQCHSLKSFGSEGLKLVAHEETVSFGQSVLKLTFDPGSQEDGLLTAECSLDHPFYVKNKGWSSFYPSLTVVQHGIPCYEMQVGDLCLPPGHPDAINFDDSVVFDTFRSYDFTPLDSSAVYVLSSMARQRRASLSSGGAVSPDCEKSSRDFEPSGSSQPSCTFYSKSNKSHSSGTANSATPTKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTMEAKALAEEQKRLNPDCWKRKRTSSGSQQN
The following text describes a protein:
Function:
Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway.
Subcellular Localization:
Perikaryon. Synapse. Endomembrane system; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Note=Intracellular membranes, mitochondrial, and perinuclear region. Localizes to synapses of DD motor neurons. Synaptic localization is dependent on axonal mitochondria.
Sequence:
MVDSMDMANSSQNTFRRRTMATSEMREFLSTKDAEPNNFGMQTIPESPTPSTPTRRMSIGDSTRIYDWEEPRFNIQGFVVDYFTYRIAQNGLDWYDAPALPDGVQKEHEMMRSLGTIFEKRHMEMFENFSEQLLAVPKISFSLYQEVVQTVGNSSNTPCPMSYGRLIGLISFGGMVAAKMMESAELQGQVRNLLMYTSLFIKTRIRQSWKEHNRSWADFMKLGQQMKEDYEKEKDAEEGKRLKSWSIIGASVIAVIVCGRIIFSFK
The following text describes a protein:
Function:
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex.
Subcellular Localization:
Nucleus.
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
The following text describes a protein:
Function:
Plays an olfactory role that is not restricted to pheromone sensitivity.
Subcellular Localization:
Cell membrane.
Sequence:
MDVKLLKTNKVPVHLPSRRRNSSTKALFIICLTTTLSIACFTMGLFFHIYKPTKLILDDRLTMRQIMPYYRWWKDTDDVLVTCRIFIFNVTNSERWLGGLDDQLKMQEVVPIVYREILEHDNVTFHEHNSTISYVTRRRLVFLPDRNVPGILNKTIIVPNISLLGVAARMENDNFFMKRGFNFIYSMSGDTVFSRMTIYDYLWNTRPPFLDQARKFVPGMVPSDNVGVLKTMYEDHEDHVNVRHGKRYGDDQFFMMNTYEYEPTVPGFSLAKGDCFASILNSSEGATYPQNLDEQSVLIYWRKTLCRAVPLYFERRVQKGPLTGYKYVLPDNSYDRLPDSDADCYKGQFGLLEDGMTDTSKCSHDVPIVATSPHFYARNFSNAHKITGMIPDRENQHSYAIVDPSFGIPLDQCARTQTNLAIPELTGYSADIKRFSDMIIPMFWIEYHQQELPIYIIRTLQAFYVIRDVEPYLPYVLYLCFMLLLAVAFREAARYKMQGKISPAKYTKPQLTSL
The following text describes a protein:
Function:
Involved in protein trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MGASFRSYVWDPMLLCSQIIAMQSVFYVCFGIWLIFVDYILDHPRSLGQIFGYDCLDFSSSGGRMIAAVYVMNALTCATGLWCIVQRTKQCTDFSVTVHFFHFIACWMYNSRIPSSLAWWFTNIGCIALTTVLGEYLCMRTELKDIPLTGARADL
The following text describes a protein:
Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins.
Subcellular Localization:
Cytoplasmic vesicle membrane. Late endosome membrane; Peripheral membrane protein. Note=Membrane-associated. Colocalizes to large vesicle-like structures with PDCD6IP/Alix.
Sequence:
MKLFGKPKPKQDTQETIGKLRLTLDMLEKRQTFLQDKLEKEQEKAKVLVSQKRKREALLCLKKRNNFQNEVTKLQGSYDTLNQQIFALENAKMNMEIMNSMRDGARSLRELHGHLTIDKVDDVIEEIQEQMEIHEEISNAISQPLGNQVEDEEELLRELAEYEQEELDAQLLNIKAPSRELPQEIQVNFPTISKTVPKLSKEEEEIRALEESLAM
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MGEDDVPFDDKAKRTRDLLSSFYSPDPSVSNTSNSFKFASLDAINTTSFDAEQYMNLLVQKSNLEGLLQRHVEMAAEIKNLDTDLQMLVYENYNKFISATDTIKRMKSNIVGMEASMEQLLGKITSVQSRSDGVNTSLFEKREHIEKLHRTHNLLRKIQFIYDLPARLGKCIKSETYADAVKIYIGAMPIFKAYGDSSFQDCKQASEEAMATITKNLQGKLFLDSESIQARAEAAVLLKKLNFPMDNLKAKLFEKLEQSLEGLQLKHEDIANVLVESNNPSEQGNNTESVPGSAHDALVCEFAEAVRAYQVIFPDSEKQLIKLSQDLIAKHFEITAGYIKEWIPIANFLGALRIIWKDVHLMDKVLREALLPDCSLKASQVAVKQYIKSTFSHLLHDISDSLTNVHIKPKEEAKEHLLVVFLEAGKTAVLQGSVNVLLDFRQLLEENLGGLQLSNLIIVWVREGFQDFFRALHDRLLLISGKNKSASQDENSTEGMQVEKVIPGLVLVLAQLSVFIEQTAIPRITEEIAAYFSGGGGLASENGPALVPGEICRTFHSDGEILLQHYINMITQKILVLLRKRFTAPNWVKHKEPREVHMFVDLFLQELEAIRTEAKQILPHGVLRKHRRSESNGSTASSRSNPLREDKMIRSNTHRARSQLLETHLAKLFKQKVEIFTKTEYTQESVVTTVVKLCLKSLLEFVRLQTFNRSGFQQIQLDIQFLRASLKEIVEDEAAIDFLLDEVIVGASERCLDPIPLEPPILDKLIQAKLAKEKEQTPISL
The following text describes a protein:
Function:
Chemotactic for CESS B-cells and THP-1 monocytes, but not T-cells.
Subcellular Localization:
Secreted.
Domain:
The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Sequence:
MRLLAAALLLLLLALCASRVDGSKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKMVIVTTKSMSRYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE
The following text describes a protein:
Function:
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the bicoumarin kotanin. The non-reducing polyketide synthase ktnS first catalyzes the formation of the pentaketidic 4,7-dihydroxy-5-methylcoumarin from acetyl coenzyme A and 4 malonyl coenzyme A molecules. Further O-methylation by ktnB leads to the formation of 7-demethylsiderin. Then, an oxidative phenol coupling catalyzed by the cytochrome P450 monooxygenase ktnC forms the 8,8'-dimer P-orlandin via dimerization the monomeric precursor, 7-demethylsiderin. P-orlandin is subsequently O-methylated in a stepwise fashion to demethylkotanin and kotanin.
Domain:
Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm (By similarity).
Sequence:
MLADMCVGVYKAAMNYEIRPHEFSFNTQESLFTGLGLGFLAATAVVASPSLLDLPITAAEVVRIAMRAGILLYQKSQDLEQLSLDSSLESWTTVVRGLDESIVRGELEKFNKSMETPPSSRIYISVVEPDGSVFISGPPSGLREFFNKSGKVQSAPRAPLPVYGGPCHAAHLYDRTHTEWVVSKVNPEIASRRLSGHPLVLSMGDGQPLAGENARDLFESATYVLLTSIIRWDSVLAAVKKLPHWKQDTKLQLETFRPSSPAVHGLISAVQSEYPDCTVSVDDLGDWIIDNSLEPPTIPIDSRIAVVGMSCRLPGGSDDLQRFWELLEDGRDVHQKVPGNRYDVESHTDMTGRRLNTSHTPFGCFIDSPGLFDASFFDMSPREAGQTDPTHRLALLTAYEALEYSGYVPNRTRSTTRDRVGTVYGQCSDDYREANAGQNIDMYFIPGNYRAFAPGRISYFFKFSGPSFNCDTACSASLAAVQIACSALIRGEADMVVAGGLNILTGSDSFAGLSRGFFLSKTGNCKVFDDGADGYCRADGIGSIVLKRLSDAQQDNDNILGVILGTATNHSSHAISITHPHAPTQEHLYRSVLSQAGIGPHDVDLVEMHGTGTQAGDAAEIESVTRVFSPPVPRRSHPLYISSVKANLGHGEAAAGITALMKALLIFQHNAIPRHVGIKTALNSKFPDLERLNVHIPKETIPWPYRSNRKRYVMINNFSAAGGNTSLLLEEPPVRPDPQGPPQTRFVVALSAKSTTSLRRNLESLITWLEGNRSARLASLAYTTTARRMHHKHRIAVHGASVAEIIQALHQRGSRAELGLLVSKPPSVAFIFSGQGSFYAGVGSQLFKEYPPYREQLQRLDEICQQNGFGSILPAITDTDADVSQLSALVTQLTTVCVQIALCRLWRTLGVKPAVVIGASLGEYAALYAAGALSASDAIFLVGQRTLLMQKLCTANSYGMLAVQGSVDDIRRCVQDRTYEVACINAPRSITICASIKDIVDIQQSLVSQGYRSVKLNVPFAFHSSQMDPILDRYEEIAKAVSFRSLQIPLISSTLADAAVQSRSLVASLFLRENTRAPARFAEAVAKAQDMGLVNSHTVWVEIGVHSTYSGAVRATVADLQAIVPSLRSDETNWHTLAVSMCTLQETGVPLDWNEWYRPFEPEVRLLDLPSYRWDLKNHWIQYNGDWLLVKDKRPRTDQISAATPSLRTALVHQIMEESFRPDGGEIVVQSDVMDKEFFAVASGHKMSGRPLVSVFSYPDIAFTLARYMYSRLKPESPLPAMDFGQVRVLQGLLPRKDRSKPQWVRMRMRADPQCAALQLSISGLSDESSRHVEEKLASGVVRCGDRQSWQDEWADYAHLLTTRIVTLQQMAENGQASRVSRDLVYTLFKNIVDYADHYRGIQSAVLHGLEAVADVILAPSNDSRWTAPPHHIDPITHVGGLVLNAGHATDHHNTIYVMEGWKSMRFAEELVAGELYRSYVKMNPARDGSGFFVGDVYVMREDHIVGKVRGMTLRPLPRILMNRFFDPPDDGDGLATQHIQPHDLPQVQHQPSPTTDSGPDDDPKDPNTGPLTPEVDLPVAPSVEKANTKLVRGALALLAAETGVEPDGLTDETEVSALGIDSLLSLVLVEKFATELQVNIQSSFFLESPTIRELKEYLTASW
The following text describes a protein:
Function:
May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFQITFKILNWIRPYKARMILGFSMSFLNAIFIALPIFLAAKIFNNVLSHKPIYMKDILNVVIIMVLLVIGRFITAYFKSKSHESIAYEMSAKERLDIGDKLKNVRLGYFNSHHSNELTTIVTTDLTFLENFAMKMVDVVVNGYILITVLILSLLVVSWQVSLLACIGVLLSFFAIQLLERKSRQNAPAYHNVQNQLVEKVLEVIRGIQVIKSFAKENTSLKSFNQAVNESKRINTKIEMQYIPFNLLHLLSLKVVSIMIVLVACLLYMNHSIDLPTLIMISIFSFVIFDSVENINSAAHVLEMIDMTIDDIEKIKNAPELDENGKNLTIKNENIAFQNVNFSYDDKQVIKNVNFEIPTQTSTAIIGPSGSGKSTLCHLLLRFYDIDDGNIRIDGVDIKDMTLSTLMSKISAVFQKVYLFNDTIENNILFGNPGATKEEIIRAAKQACCHDFIMSLPEGYQTMLNEKGSNLSGGEKQRISIARAILKDAPIIILDEATASIDPENEQLIQTAINELSKGKTVITIAHKLETIKNADQIIVLNEGEIIQKGSHDELIRKPGMYQDFIRIKSKSAGWKL
The following text describes a protein:
Function:
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MDNLHYNIRYGFLDGYVRACFTEFLTEADYMQLKQCETLEDFRLHLSNAGFQSYLQNDAGTASPTVIYERCLERLVDKFNYVESQASDELKTFFQWLRIPFMIDNVIIIISGVVHDHDVTELIERCHPLGMFDGIKALAVASTVQDLYQMVLVDTPLGPLFSKCLNTNSLSEQNVESIRLKLYREYYDQFYEFCKNLGSETALVMCDLLEFEADRRAIIITLNSIRTSMIADDREALYPRIGQLATITSKLAAKGAGETTLADALQPFETYKKLFDLSRTSSKTIEEVFLERAALMHVESFSVFFSFAVFYSWVQLMDQEVRNIQWIAECIHQGKRDRADSYVRIAP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Nucleus, nuclear body. Nucleus, nucleoplasm. Endosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Postsynaptic density. Perikaryon. Cell projection, neuron projection. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas.
Sequence:
MPRSALSVISFCHRLGKQERKRSFMGNSSNSWSHTPFPKLELGLGSRPTAPREPPACSICLERPREPISLDCGHDFCPRCFSTHRVPGCGPPCCPECRKTCKRRKGLRGLGERMRLLPQRPLPAAALQETCAVRAEPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGGPHSGKTFLLNHLLQGLPGLASGEGSWPRSAGSGQGFRWGANGLSRGIWMWSHPFLLGKEGRKVAVFLVDTGDVMSPELSRETRTRLCALTSMLSSYQILTASQELKDTDLEHLETFVHVAEVMGRHYGMVPIQHLDLLVRDSSHPSKAWQGHVGDVIQKSSGKYPKVQGLLQGRRARCYLLPAPGRRWASRGHGSSGDDDAGRLRAYVADVLSAAPQHAKSRCPGYWSEGRPAARGDRRLLTGQQLAQEVKNLSGWMGRTGPSCASPDEMAAQLHDLRTVEAAKKEFEEYVRQQDAATKRIFSALRVLPDTMRNLLSAQKDTLLARHGATLLCTGREQTLEALEAELQAEAKAFMDSYTVRFCGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAGLAATVGCMEKEEDERVQEGDREPLLQEE
The following text describes a protein:
Function:
Links the unfolded protein response and programmed cell death and mediates mitochondrial-dependent apoptosis. Induces cell death and disruption of the mitochondrial transmembrane potential via the mitochondrial phosphate carrier MIR1. Dispensible for starvation-induced autophagy.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Translocated from predominantly vacuolar sites in healthy cells to mitochondria upon apoptosis induction.
Sequence:
MSGPPPPYEEQSSHLYGQPASSQDGNAFIPEDFKYSTVVISCEPIIRQRFMHKVYSLLSCQLLASLSFCYWASVSTSLQNFIMSHIALFYICMVVSLVSCIWLAVSPRPEDYEASVPEPLLTGSSEEPAQEQRRLPWYVLSSYKQKLTLLSIFTLSEAYCLSLVTLAYDKDTVLSALLITTIVVVGVSLTALSERFENVLNSATSIYYWLNWGLWIMIGMGLTALLFGWNTHSSKFNLLYGWLGAILFTAYLFIDTQLIFRKVYPDEEVRCAMMLYLDIVNLFLSILRILANSNDDN
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDPHGDLGGHDCWIPLDSRAASTPDFVLTRTPDSSRFMNSTTESPSDAIATVRVIPGGPVCGSIRPPGSKSLTNRALLMAAFGRGTSQLEGALVSEDTHVMTDSLRKIGVEIESHDAGRTLVVTGVQSAPESDSPYDLYIANSGTTVRFLTAALSALGGNYVLSGVPRMHERPIGDLVDALSPVVDGRIEAVSEGGCPPVHIQTAGWAKHELSVAGSVSSQYLSGLMMAAPLASRRSNQPVTIRVVGELVSRPYVEMTADAMQVFGASVELQWPAAAQDDVLVQISGDYDAIGWSIEPDASAASYFWAAAAISGGDVTVNGLSRAATQGDVAFVDVLEMMGCQIEEGEDSIRVIATNLPGGQLRGVDVDMNAISDTVQTLAMVALFANSPTRVRGVAHNRFKETDRIGDLASELRKLGATIQEHDDGMTIHPLSEPAVSDESPVRLDTYHDHRMAMSFSLAGLRLGGIEIENPACTGKTYPNYWSDLEQLIGRAHHWTAE
The following text describes a protein:
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLPYAPCIQP
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Does not have cyclase activity (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLKFQGSTHFRQRIICSTLSGKAIRITNIRDEDEKPGLRDYEASFLRLVDKITNGSKIEINSTGTQITYIPGIIIGGKGITHECGTVRGIGYFVEALICLGPFAKAPLDITLNGITNNDIDLTIDTIRTTTLPIIRKFGIEEGLIIKIIKRGAPPNGGGSVNFKCPIVPHLKAIQLIDEGKIRRIRGIAYATRISPQFSNRVLDKAKGLLLEYTPDVYISSDHYKGNESGLSPGYGLTLVAETTTGCCLSAECMSNTGIATTEQQLQKQKSTSETPEDLGERTAFALLEEIFNGGCIDSHNQSLALLFMVLCPEDISKVRLGKITPYTIEFIRQLRDFFGVTFKIEPDQNSKTVLFTCLGIGYKNMARSTF
The following text describes a protein:
Function:
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRNQIDKIRLLFRKDRESYLCFYRILGFYPHNIQIYEQALLHKSSAVRSEKGRPLNNERLEFLGDAILDAIVGDIVYKRFEGKREGFLTNTRSKIVQRETLNKLAVEIGLDKLIKYSTRSSSHNSYMYGNAFEAFIGAIYLDQGYERCKQFMEQRIINRYIDLDKISRKEVNFKSKLIEWSQKNKMEVSFELIEQFLDHDSNPVFQTEVRIEGLPAGTGTGYSKKESQQNAAQMAIKKVKDQTFMDTVNEAKSQHSKPSEVETESVEPELTESETMEPDTLETEAPEAETTADKVETTVNEVEATETEKE
The following text describes a protein:
Function:
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein.
Sequence:
MLEVIIALTIFCIAGLSIMKIISERLRWINILEQRMISSWVAENVLTEIKILKIEQTNEWLMGQESMAGQLWYWQSRSIKLQDDRMEIIAVEVRNNKESEHPDFSLEGYKTTND
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
KIQNDFFFRRPPLHRRKQLRGGVMNAAADGSSYGYDALYSHLAALNLSGQPSHPPHPAYDEGASSSHGAAGGVGSNIWRCEPLLNGFVDFNSNGDDTINRMRANSAARVYMQPNPNENHLYNNVTGANYNYNINYNNYGRSTLNGFAFHNSNANFDLGHGNRQLRYSTRNNNNNSSGFEYMKNRTESNSAPTWISNFRCGYSGSLNRLGMRLDSLSLEELRGKLVSVVMDQYGSQYLQNKLEGIDPNTVEFIFSELKGHICYLMVDQVANQFIQKFFKVCNENQITEFLYLLVTDHVKFKDICCDMHGTRVVQKLLDKLTTPNQVAIALSVLRRITIELTRSMNGQHVIQHCLKSFPPQDNEIILQVIADNCLAIASDRSGCCVLQPCVSSAQGETRNRMIANLTAYALLLSTDPYGNYVVQYMVDMPKVKVQILTQLSGNFVPLSMDKYGSNVVEKCLKGYNGNQLLSILNEIMNSPNFVQLLQDPYGNYVAQSALICSKGAARDALTERIHSNYAFLHSHPHGKRVLERARCCKIYRA
The following text describes a protein:
Function:
Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro).
Subcellular Localization:
Nucleus.
Sequence:
MVQLAPAAAMDEVTFRSDTVLSDVHLYTPNHRHLMVRLNSVGQPVFLSQFKLLWSQDSWTDSGAKGGSHRDVHTKEPPSAETGSTGSPPGSGHGNEGFSLQAGTDTTGQEVAEAQLDEDGDLDVVRRPRAASDSNPAGPLRDKVHPMILAQEEDDVLGEEAQGSPHDIVRIEHTMATPLEDVGKQVWRGALLLADYILFRQDLFRGCTALELGAGTGLASIIAATMARTVYCTDVGADLLSMCQRNIALNSHLAATGGGIVKVKELDWLKDDLCTDPEVPFSWSQEEISDLYDHTTILFAAEVFYDDDLTDAVFKTLSRLAHRLKNACTAILSVEKRLNFTLRHLDVTCEAYEHFRSCLRALEQLADGKLRFVVEPVEASFPQLLVYERLQQLELWKIIAEPVT
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNEEEDGDGQSSSKKVVPSFKFQCPVILEQGPSKPSSPTIYTGSSQITADLMQQIQMFTSHFDAARLSPNYATSDLGSSARSSFSTSSWMNYRDRFADYDESGKEMGSPFDCESTHSVSPAFSLSPNSFNHFSFDARSVSSLGHSTTNLNHLLSVGAAFELSRERSRSESDMQPMQKDADEASLLANSTVSVPCYTKKSKFGGEIKRSSSTPPPTTNEREEMERMTTRPTSVMENKETNLLVNNWARDQFLAIQNAMPIYNLLTKSSEDCSSLSTPGPLKVVPKSKDDMTFLMRDENNRAKEMQYPCTMCGQAFAVHDRLAKHIASRHRQRSCTLDDASKVHKCNMCTKSFARSDMLTRHMRLHTGAKPYSCPTCNQVFSRSDHLSTHLRTHTGEKPYACPICNYSASRRDMISRHMRTHSMSDDVSTPLTQLSIRSASTSPLPPKIATAVVEIGSGERSAFKPILSTSLSSHHLSVSSPFQSLSLSTPSSPSFSPQNNSLFLNRQYSFDNSIISETLNLNLNLNSSSTSNLNLNSNPDSKNS