lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
As part of the central apparatus of the cilium axoneme may play a role in cilium movement and thereby cell motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MALTAEEAYLEELWREEDEQSEEATAMQQMLAHQHEQQHDALPSYQELMGQGSPAVTLRRAKAAAAANGTSSPGIRGSPSPARGPGGRLPSLAMGPTVGANVEQLKRRLQTVVAEVEGHQQRYDKVLLEANKATDLVHSMEAEIESLYVEAEELARRVPPAAERQRQVATWLAQRSAALEAQRQVLGGKQLELIEAEAALRAAETELDFMAEARNEIAAAQAAETAALSAAAATLRGKEDKAVAGYRRKQAAEAARLADVAAAAEDLAQRRIQAAEEAQAQAMERLKANTERIREGIASGRDLLAAEQSRRREAVLGLKESLAAVQADVAQQAELARVLQRQRRDLQEKEFGALVEAGMNPYEVFRRRDQEAAAARQHEAITSNIATRQLEVAAQLAREQEAYAQKLAARKREKKTREIFDREMGPAAQQARTEAYMQAHTVGGVSMLDPTGRVQPFPSEAVVVKTRRFGRGGAPEEVLQQQLQRLGDDTQPKQLLLPAKYRNTADTDAAAVAGLGRGGGSDDEDGMGSPPRSPSLTQQLAATQQSLTATASLAQQQQQAAGDRYKQLATRALTKHEQGLMEAAKTRHKGGIGAPQTQMGRTFGGDAFLPSPAVVEFKDFDVGRTVSASVQIINRSYKKNTFRVTGIPVEYCDVLDFAYKLPGYLAPGVSGEVVISFTPKAPVDIDTSLQLLADTGPFEVPIRCRTKRAALSVSPSAVDFGAGVTLGECATRTFTIANDGALEVEFRLDSPQLSEDERALLKSTANMAHLMTSATVAAAAAAAAATASGQGPRSARSFANMGVADGAAPETDTGPLVAPREERRLAHGGFTVFPCVGHLKGYSKVTFTVTFAPVVAAPAKLLLHASYKAPAMKRLALPHHEVTLTGTGRDVPVYVERPLIDFQCCMLGHLYRDVLVVRNGGKSAMKVMVVPRPELEGFFEFSPDFGFVQAGDSFPITIRFKPTPALLHACRKHVVEPEEEQILEIGMRLSVPDQSLPVPFTLRAQITNTDLLFQPPALDFGDCVMGERTAVKLLVRNPGRLPQTFGFVGLPSGLHFTPNDGFGYVLPGEALERLVSFQPPIAGPQTFSITAKTLAGRSFTLPCRANGVAPPVVLSSNRVRMPATPIGDTRTVSVVLINKTDQPQSYEFAVPADSDLTLSPHVGRVPPQSRLRVQIDYSPRPPVDGEQQGALPPPSAPNTARGPRDGGGGGAMANGNGSGGYEHYNDDGEPEDGEGDADGHTDTDSFQSPSARASPVQPLGRGGRGGRGGAAGEDEDEDEDAGELPVRGKSSSSSKASSGRRSSSPQLGGRQGLAMGRINEVPDDDDADAEAEAAAEAEQRTALAALKRIQSMGGGDPGWYRWREHAITCYIKPQSQNPTPSQSQSGQAPAASAPSDGASGAAAAAETAASSGPAAAPPPQEIHLQVATCAVLPDLVLLAPPDLPYVPLHQCHCLDFGPVPVGQRVVRRLELANEGEEPLVLGAESMDSREVFGLVNALRPVRPGASFRVMVSFTPQARTEYLEVLVLKSARTRLRLALKGAGIAPELQLGPEGVTATGLDMGDVLVGEAAARTLTVTNVCPFPLSFTMRLAGKASAADPNPTMRQAFSCHPAEGTLAQGESCEVAVSFTPFSQRPYFEDVLQVVVPNQQDQLLVPLRGRGWREAVFVAGPDYPEPQPDPFLLHHLAKQAGVALPPSVSGGGAAAGGAAVAAAAAGDKPSTPAPGIKPPATPPGGASKGKAAAAAAAAAAAAAAGASEPRELTLNFPHAIYPGEVATASFDVGSLKSTASGSAPGEVGVAELPAEAREAGWAVTDPPTAGAGGGGKVPLAAGERKPITLSYSAPAAPHPGMVAAYGHAEYRVLKLQLTLKGGLAALSGGPEGRKVVVAARCRLLPGSRPPGEPVPPGVTPAPEPVAASGPGAGAAGVKKLVPPPSPPKKAV
The following text describes a protein:
Function:
May be involved in protection from oxidative damage.
Subcellular Localization:
Mitochondrion.
Sequence:
MPHHHSLPTSSADFGDFNSAPASSIQTSSLSQDDLLGSYDETIRHSPSVKSHPSPDPRASNLDLLFLDHNAEEHRRPEPTYSPRSRPTGVLPESVPHARSPRRLSTFSSSTSPTSPPSITDAGCDIIFHPFYDHMDVNATRAMQKMQGHGERGASKRSDKMQLRGQASHSRIAPSSSPPHSRLLDTLATTTKLASKWRSVITHPTSPNTADQTHNGQPKPQIRHAETSPMDITHDTPFASAEQIAGSYIPPTGAPGFTQASVLGMKHHGDGPFEPLTLIGRKDSTSNVLTPEDAIGLKACLPPRQRLTNQWTLLFSLDQHGASLSTLYRLIDIYSVSHQSSGNILVIRDGHGNRFGTYMNEPIVKREGTYYGSGESFLFKLTHSCQTIPYRWTGKNKYFALCEAGFMSFGGGAGAYGLILDSTFTHNSSATCPAYNNDILCELEPLKSQHAQSFQCLGLEVWSTL
The following text describes a protein:
Function:
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Sequence:
MSWDYRPLLSGQSRDPFSSMARGALWCASGFYNVAARHRRRQYDSGNREICNAGVPVISVGNLTTGGTGKTPVVADLCRRLRAMDFRVTIISRGYGASDGRMNDEAMELQERLPDVPHVQHPDRVEAARIAVEELAAEVLVMDDGFQHRRLQRDLDIVVIDATCPFGYGHVLPRGTLREPLDSVTRADWVLITRVDQVDPEEVLAIRSTIAQHAPDCPVLETEHRPSTIQSSVGDWEAIEVLIDQPVALVSAIGNPDAFEQTVLDCGAIVVDHLRLPDHDSYERATREKLRSWVTKLKGGPQPPQRLLCTHKDAVKLATDSIAGVPLGYMPIELAYRTSEEPLQLRLELLMGGSVENQSSRDDSA
The following text describes a protein:
Function:
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
Sequence:
MFSGIVEEYATLVALVKDQENIHFTFKCSFVNELKIDQSISHNGVCLTVVNLTDDTYTVTAMKETLDRSNLGLLKVGDKVNVERSMMMNGRLDGHIVQGHVDQTATCVEIKDADGSWYFTFKYAFDKEMAKRGYITVDKGSVTVNGVSLTVCNPTDDTFQVAIIPYTYEHTNFHTFEIGSVVNIEFDIIGKYISRMIQYK
The following text describes a protein:
Function:
Required for vacuolar assembly. Provides the t-SNARE function in a late step of the vacuolar assembly. Required for homotypic vacuole membrane fusion, autophagy and fusion of biosynthetic transport vesicles with the vacuole. Required for the delivery of alpha-factor receptor-ligand complexes to the vacuole.
Miscellaneous:
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Single-pass type IV membrane protein.
Sequence:
MSFFDIEAQSSKGNSQQEPQFSTNQKTKELSNLIETFAEQSRVLEKECTKIGSKRDSKELRYKIETELIPNCTSVRDKIESNILIHQNGKLSADFKNLKTKYQSLQQSYNQRKSLFPLKTPISPGTSKERKDIHPRTEAVRQDPESSYISIKVNEQSPLLHNEGQHQLQLQEEQEQQQQGLSQEELDFQTIIHQERSQQIGRIHTAVQEVNAIFHQLGSLVKEQGEQVTTIDENISHLHDNMQNANKQLTRADQHQRDRNKCGKVTLIIIIVVCMVVLLAVLS
The following text describes a protein:
Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
ARVRRGSMATDQSGGVELDRSQVKKAAQALLAYLKSTPSSGSVLLDEHQHISLLFTLWKVPKKEQTIRIPLPHGLRLESGDVCLFTKDEPNMTSDQTERFYKRLLSEKGVKGITQVMPFRVLKKEYKSFEAKRRLLGNFDLFLADDRVRRLLPSHIGKHFYQSKKAPLSVDLQGKQLARDMTRLIQGSTLGVSNKGPCCMARVAHSEMSVDQVVENIAAAFSTVAEKLPKKGKSIKIVHLKSQSSVSLPIYTSDLSHLALLEGGSDSAEKAEKADKPKTKKKRVMSTLGKHESPAAEEEEIPRLVPIETPPKKARREAPARKELESAPQTVEIKGSKPLSSPGSLPATAGKQGIGAKTKVSQTPKKPLAPRRLPGVLQRKTPPKKTQGSSARSKLSKSAKKSPRTPLQKRKKRTVPQSC
The following text describes a protein:
Function:
Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MIAVFLVCLLSWCRSSAVATALPPPQDLTMVAINTNYTLRWNYKQSAALPNQVTFTTEFISKYMLTIKKKPPVWKPACKESPEHSCELTSFDLYYFSIYKLRVRASVNGNHSAWAFKEFCPDKDTGIGPPSSVKLTLAGYSLEVSIVDPLTSTNSSMKDYMADLSYNICYWERHEDEEALIMETISTNSNVVALSGLKPLTWYCVRVQSYTKYYNRSSSFTSPLCMKNDGHAPCWQILLIFMAFLVIVVPLVVLLAVGSFRCSRFWKSVFHPELPSFLIESRRDSTGGRSPQLITMSIESERLCDNMTVCPKSSVLETLSLLKESAAPPLGLNPDSRSLKVLHICF
The following text describes a protein:
Function:
Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus.
Subcellular Localization:
Golgi apparatus. Endosome.
Domain:
The C-terminal domain (551-712) is responsible for the Golgi localization.
Sequence:
MWSSIENMKANLHKIVLDVHEDDEEEDDLHKYGSANGVSNSDRRNSSGFRSVSRYSISNGIESPAHHEIERYKAEIKKLQESESDIKALSVNYAALLREKEDQISRLNQENGSLKQNLTSTSAALKEARTDISRGSNNYAIKGNNDQSPNRLHKSVSHLKSPNHMSNGKGKDTDSFIKEKDLADMLEDRTKSMAAVQATELAKEREKLRDFQLSLQEERKRSESFKEELESMRLDKNKTSMEISKMRSELDAKLLEIKHLQMKLTGQESHAIGPGMEHLKEVNKALEKENNELKLKRSELEAALEESRKLTNSKVFPDATESLTRHPSTLDKEKPESFPGKEEMEQSLQRLEMDLKETQRERDKARQELKRLKQHLLEKETEESEKMDEDSRLIEELRQTNEYQRSQISHLEKSLKQAISNQEDNRLSNDNQIRKLKDTVDDLNQKLTNCLRTIESKNVELLNLQTALGQYYAEIEAKEHFERELAMAKDELMKLSARLKDSDERLESSNKEKEDVTSKLLHAEKVAAEWKNRVTKVEEDNAKVRRVLEQSMTRLNRMSMESDYLVDRRIVIKLLVTYFQKNHNKEVLDLMVRMLGFSEEDKERIGAAKQGGGKGVVRGVLGFPGRFVGGILGGKSAELHANAASDNQSFADLWVDFLLKDAEERERREAEEAAASKAKQDSERTRQEAALHDSEFSTVPLRSSESNQRLSR
The following text describes a protein:
Function:
Probable metallophosphoesterase which may participate in recombinational repair of double -strand breaks.
Miscellaneous:
MISCELLANEOUS: Present with 583 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVYRNRSKSVLSTHSKKSDDKAHYKSRSKKKSKSRSKKRLRIYWRYISIVWILWLGLISYYESVVVKRAMKKCQWSTWEDWPEGAESHRVGLFADPQIMDEYSYPGRPQIVNYFTRVIVDHYHRRNWKYVQYYLDPDSNFFLGDLFDGGRNWDDKQWIKEYTRFNQIFPKKPLRRTVMSLPGNHDIGFGDTVVESSLQRFSSYFGETSSSLDAGNHTFVLLDTISLSDKTNPNVSRVPRQFLDNFAMGSHPLPRILLTHVPLWRDPEQQTCGQLRESKEPFPIQKGHQYQTVIENDISQEILTKIQPEILFSGDDHDHCQISHSYPFQGKTKNAQEITVKSCAMNMGISRPAIQLLSLYNPSDLTMVNAGGEYASKTYQTELCYMPDPYKAIRMYLWGLLFSAAFIAYMHFFPKSFNNRVATIMNRVFTRPDGNTSDLPLPTSISKSKSKKSLTHSKYAVNDTRSIKQFLVNAIVLFVSVMPIFIYFYTVV
The following text describes a protein:
Function:
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MAAAATAGSGTPREEEAPGGEAAASQAQAPTNAPGGARLSRLPLARVKALVKADPDVTLAGQEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MDSRPTIAEVDLAALRHNYDLVVRTIPRGCGILAVVKADAYGHGFMDIARELETLGVTAFGVAFLAEGIQLRKSGIDRPVLILGGVYPGQERKCVGFNLSTALFSLEQARVLDDAAGRLYRRARVHAKIDTGMGRLGIPHEEASAFFSALRELKHLDLEGIISHFASADELDEDGRRYSDLQASRFAAAVAAARHEGFEPRYVHIANSAAAFGMDLPFCNLVRPGIVLYGALPSGDFEGKMALKPIMRLRSSIAMLKWVEPGTSISYARRFTAPDRRLVASIPVGYADGYSRSLTNRGEVVVRGRRAPVVGTVCMDWIMADVTHVSGVTVGDEVTLLGCDQEGNCVRAEELAEWAGTIPYEIFCGISKRVPRVYLNPSIRHR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
Domain:
The RanBP2-type zinc finger, also called Npl4 zinc finger (NZF), mediates binding to 'Met-1'-linked polyubiquitins; The UBL domain mediates association with RNF31 via interaction with its UBA domain.
Sequence:
MDEKTKKAEEMALSLARAVAGGDEQAAIKYATWLAEQRVPLRVQVKPEVSPTQDIRLCVSVEDAYMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPSLQQWVVGQRLARDQETLHSHGIRRNGDGAYLYLLSARNTSLNPQELQRQRQLRMLEDLGFKDLTLQSRGPLEPVLPKPRTNQEPGQPDAAPESPPVGWQCPGCTFINKPTRPGCEMCCRARPETYQIPASYQPDEEERARLAGEEEALRQYQQRKQQQQEGNYLQHVQLEQRSLVLNTEPTECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVACPFIDSTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVCTRVNCLLCKAIHEHMNCREYQDDLALRAQNDVAARQTTEMLKVMLQQGEAMHCPQCRIVVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
The following text describes a protein:
Function:
Accepts electrons from ETF and reduces ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MLVPLAKLSCLAYQCFHALKIKKNYLPLCATRWSSTSTVPRITTHYTIYPRDKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLDPGAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVALGLVSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTSENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLTLRDDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSGSGSDLVSPGTARAIDSGRESIGVLLSTAQDRLQHVFIAFVVGLLAGIFVMRLFIWPTLEADLLPANAEVIAQTPFEVILMQVKIGLFAGVLAALPVLAYHAKRPLQDRDIVPPISVTRWQLGGVLVIAAGLAALGVLYAYFAFFPLMFQFLAGNADTVGLSPKYSIVKWTEFILFLSLSFSLAAQLPLLMSGLSYSGIVAYETFRDKWRYAIVAIATFGALFSPPDPFTQILWATPLVLLYGLSLYVSKIVVTVKRGRDDIDVRGVFRAAWNRILGVVVLGFGAGYAVEQYNGIQLFNDGLAALGSGVRVPTVERALGVPTDTAVLVLGAAFAALAVLAATLYYLYVAVDRAAARNGPRSRRPDPADIDLNALDAAGIEAAPPEAFAALSEDEALATASQAMDDGDDRKAELVLDRFDAAAADDDDTGSEADNPDAESSATMQRTAAGMMDAFTEDDTTEDDIGGYYHDLRFIFDSLRSRAFRIVGGFMLVMVGVFGWLYYGGLATLRYDFITRIPQEIQPDANSWPITLHPVEALVFQVKLSVVIAAVAVVPLLVYYLWPSLSERGLVTGDRSTILAWGGSLAVTLVGGSYLGYAYIAPAVISFLVGDALQAGMVISYTIGTFAWLVFLLTVGIGLLASIPVTMVLFNHGNIVSFDTMRRRWRVPVLATFFFAALATPDSLYTMFIVALPVATMYGLGLAILYALTLGGRRGGDSRSTPT
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MDEKWRLSKKDALAASCSSSSTSSKSKFSRSFSTSASSSKAPAFVRSSSTKCSVPSSSSSSISRSSSKKEKGSITQKYSSLAKEQKGRFYIMRRCVAMLVCWHKHDS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
Sequence:
MSISTQITFFEFLTPLVASGQKTITIRDKSESHYVPGTRVEVFTLETQRKVCEIDILAVEPLKFDEINEFHAEQEAIELPKLKALIQEIYPNIDELYVITYQLAK
The following text describes a protein:
Function:
Probable transporter involved in ethionine resistance. Overproduction leads to accumulation of S-adenosylmethionine.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSKQFSHTTNDRRSSIIYSTSVGKAGLFTPADYIPQESEENLIEGEEQEGSEEEPSYTGNDDETEREGEYHSLLDANNSRTLQQEAWQQGYDSHDRKRLLDEERDLLIDNKLLSQHGNGGGDIESHGHGQAIGPDEEERPAEIANTWESAIESGQKISTTFKRETQVITMNALPLIFTFILQNSLSLASIFSVSHLGTKELGGVTLGSMTANITGLAAIQGLCTCLDTLCAQAYGAKNYHLVGVLVQRCAVITILAFLPMMYVWFVWSEKILALMIPERELCALAANYLRVTAFGVPGFILFECGKRFLQCQGIFHASTIVLFVCAPLNALMNYLLVWNDKIGIGYLGAPLSVVINYWLMTLGLLIYAMTTKHKERPLKCWNGIIPKEQAFKNWRKMINLAIPGVVMVEAEFLGFEVLTIFASHLGTDALGAQSIVATIASLAYQVPFSISVSTSTRVANFIGASLYDSCMITCRVSLLLSFVCSSMNMFVICRYKEQIASLFSTESAVVKMVVDTLPLLAFMQLFDAFNASTAGCLRGQGRQKNRWVHQPSRILLPRCAHGICVSIPVSSGCRRLMVGYN
The following text describes a protein:
Function:
May inhibit TGF-beta signaling.
Subcellular Localization:
Secreted.
Sequence:
MHPLWAFLLGLSLTNGLSANCPGRCSCDSMQSVQCYRLMELPSGIPSTTKRLYISHSRIQHLQLSNFTGLLALEDFILLASGTESIENDTFKTLSTLKTLELWKNKLRQVPSALPANLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLASLQSLMVDGNNIESVVGPLSLPHLKYMSMENNQLHLIPGNVFTSLQNLQFLSFSGNFLTKIPINLPKSLLSLKMERNQLKVVRFRDMKHLENLSHLYLSENFLSSIDGAQQLTNLTTLEVSQNQLQMLPPRLPSRLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDNNVVSLFEAGALQRCSQLSNLALEQNLLLSIPLRLPKTLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNPWNCTCSLLRAREVLKAKGTDVKGGQCAAPAERQGESWMSSKKILRQCEHHLQQSEKSKETKKKPKPEDSSSIRLNMDDDDDDYEID
The following text describes a protein:
Function:
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P). Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MENIKVAKVGNVKFVNKGNELNGTLHLTAYHSIFSISENGKEIWTAYSMINNVKLCSNEKSFCIRIQCRDFMFFCWRFQSTEDAMDVYDTLQELMSINSINMLYAFYYMPSGDEEKLPSSWKSFLLENEYRRMGVGDSTQADGAGGNWRITKINENYSECHSYPQALAVPASISDSVIYYGCKYRSKNRFPTLTYLHKNSFSITRASQPLVGIRQNRSAQDEKLVEAIFATSIIPGKENLIVDARPSTNAMANIAVGAGSENMDHYRFAKKIYLGIDNIHVMRDSLNKIVNALKNTDISAAPPLIELLNRSSWLKHLANILQGAVLIVKTVHFRHAHVLVHCSDGWDRTSQLCALPQLCLDPYYRTIEGFFALVEKDWLSFGHRFAERCCHLPGKRIFTIDSSYSEEPPQSSPSSTLQYTFSTVRSALSGFSIDHSEKMMSPVFHQFLDCVWQIMDQFPNCFEFNERFLRRLLYHLYSCQYGSFLYNSERERAQASVSTHTRCIWDYFLSRKDEFKNPNYVPYDDVIMPDPSSLRWWSASFAQPDENMNIPSPSESPSL
The following text describes a protein:
Function:
Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.
Subcellular Localization:
Nucleus.
Domain:
Amino acids 178-210 are essential for repression activity.
Sequence:
MGSTAAPEGALGYVREFTRHSSDVLSNLNELRLRGILTDVTLLVGGQPLRAHKAVLIACSGFFYSIFRGRAGLGVDVLSLPGGPEARGFAPLLDFMYTSRLRLSPATAPAVLAAATYLQMEHVVQACHRFIQASYEPLGISLRPVEVEPPRPPTVAPPGSPRRSEGHPDPPTESRSCSQGSPSPASPDPKACNWKKYKFIVLNSQTSQAGSLVGESSGQPCPQARLPSGDEACSSSSSSEEGTTPGLQSRLSLATTTARFKCGALANNSYLFTPRAQETSLPASKQANPPPGSEFFSCQNCEAVAGCSSGLELLAPGDEDKPYKCQLCRSAFRYKGNLASHRTVHTGEKPYRCSICGARFNRPANLKTHSRIHSGEKPYKCETCGSRFVQVAHLRAHVLIHTGEKPYPCPTCGTRFRHLQTLKSHVRIHTGEKPYHCDPCGLHFRHKSQLRLHLRQKHGAATNTKVRYHILGGP
The following text describes a protein:
Function:
MFS transporter; part of the gene cluster that mediates the biosynthesis of the antitumor cytotoxic peptidyl alkaloids fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts. Probably involved in fumiquinazolines metabolism and transport.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Sequence:
MPEDKVEAIEHVESSRHDATVNEKAIADFLNAEKEMTTWQAVRAHRRLLLFAAYRVTHLAILPFVCASNYGYDTVSNGSSIAMPAFIMSFGAMNHATGSMYLPSIWTSLWTSMTNLGQALGSLIAGFLAERIGRRWTAVSLAILSIVGTFILVFSSTRGMLLVGKTMNGAVVGGLMAIGTTYAADVAPIKLRGALLQAIVFFGVAMQGVSLGIVRAFILDMRPLAWKIVFGIQWAFATLVLIAAFLVPESPVFYVAHGKHDKAQSALRRLHGSSDQYLHIRYGAIVHALDEERKQQSESVSWAELFKGCNLKRTITIGFIMFSTSAIGVPFLTQNIYFLITVGLNVTSVFDIGIGGFFLGCLFVMLGWLSNEGIGRRRLWLWGLIGNFLCMVTIGALGFSTTKASQLAIAVIMNVLISYGVYATVGVAWTICPEISSHRLRQYSQSVAFIVGAVGGWLFNFITPYMYNVDSGNLGAKTGFVYAGLTVVVAVISWFLVPETAGLSVEDIDRAYEMGTAPRHFKSAKATVSAESGH
The following text describes a protein:
Function:
Along with DnaE2 and ImuB is required for the error-prone processing of DNA lesions.
Sequence:
MEAGTRTPTPVLSFGEPSIDGCFPGGGLPLGGWHEVTGAGLEDETGAAPAAFVTQLIRGLTDRKGGAVVWVARRADLFAPGLLGLGFPAARLIQVRARDEAETLSLLEDALSTQGVAAAVAEAEAPDLTAGRRLQLACEKRGGFGVVLHRRPYGGRAGGKPRLVSGSASFSRWRIAPAPSGPPPDDIGLGPPRWRVELERCRGGRPGGWILQAQEAGHGPHPFRLVSQLADHDVAAAEAGRRFG
The following text describes a protein:
Function:
Involved in oxidative stress resistance and N-glycosylation.
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTWILSTGMGPHEDKYAKHERATFKKTYSSMKTLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSITLYEPQSLRDAFTYFWQKLNSAYDNNSSFEGASQKAVNGDGKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSLMVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQSYLTSDLRYIRNQEGEVQEDTNVPEETEDYEDGEDDADEDSHVVVADESTVDVPSNDSLSDNSDGGLFPVNRPSVSHSQSPKRPKKYPKKAFNFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLERILHEMHPPA
The following text describes a protein:
Function:
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Sequence:
MSAVGCGRRRARVSRLVSFSATHRLHSKSLSNEENLKLFGKCNNPNGHGHNYKDLCLDVNLLKVMLVFWYFVLFPIVVVTVQGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADIVRGWPHGRVVKFACSAAGGPVFRWFKSWARTWHCSSNHAEAASHIPQLEGPTTKNIQLCTGGLWGEKGKK
The following text describes a protein:
Function:
Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Fimbrium.
Sequence:
MMTFKNLRYGLSSSVVLAASLFSVLSYAATDSIGLTVITTVEMGTCTATLVNDSDQDISVVDFGDVYISEINAKTKVKTFKLKFKDCAGIPNKKAQIKLTKRATCEGTANDGAGFANGSTAADKASAVAVEVWSTVTPATGSATQFSCVTPASQEVTISTAANAVVYYPMSARLVVEKNKTVNNVTAGKFSAPATFTVTYN
The following text describes a protein:
Function:
Required for proper ring canal development. Also required for the development of male genitalia and for adult survival.
Sequence:
MMGTKHRNSHVNGSIKSSSSLRSSSKSFQAKMDLMSERLYDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD
The following text describes a protein:
Function:
High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways. May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis. Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form. Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate. The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic. Involved in the regulation of citrate levels in the brain (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWANVTHIET