lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, photoreceptor outer segment. Note=Localized to the axoneme of outer segments and connecting cilia in rod photoreceptors.
Sequence:
MNSTPGDTRDAPAPSHPAPSHRQCLLPSVAHTPSVTEVTPAKKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRKPPKTSREPGRLQRKSPSAGQAQVFQGGHEAPETSYSWKGPVAPRRLTLVKNGDPRRQQTVVLSHKNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEAFRCLEMENDRGNRTRKLSSVTARSERGCWGPNAKQSVIHSRGRSGGKLRQVSLTSERSGLSDHPASGHRAWAGPALDRCPQDMPVPPGSLVAADDVEKKVCMNEDGSLSVEMKVRFQLLGEDTLRWSQRVGQASVFTAASGKGQDPREADRFCCRQEGYPWGILKPGAQGLGSYDGGCQEAFDVGQKSQPSYDIWRNPLATPEGTGPTPRRRWGLAKLSGCKSHWRQEANHRKGHDKDNLSRVSTPRHPRSVQPGSCCPWTPDGDTGSDTLHPVSSASSHNETDLESGEGLCLEDTGPHGSRPETQSTERALSDTSVSAKSREESSEGGGQLHRSSSQARVMASREQVTKGDNPCISTQSHLPLNHMGLQTEKYRQGTRGWEVSGEPELRLALVPGHSGSQDTQRDALPAPACAPAQWRQRKQKRPASVECLPSVSVPYQVAQKGHARQDHYYRDTQSSLDTALQMPMPQEREQACPGSPAPQSPSNSPSAGNQASEDLRSPFSSSLDLQEPQATSKATTIAVSGSDCVCHSTRSVEPAGDTKCQAHSSTPTPAHRGELGCLWDKAGTTPEPFSFSVLLDRCPEADDPRTYHDCCCLQAVPSSPLAAPSGQTQTSISEACLGGSSFCPTPPKEQTCFGRESASNGSTSSGHSRADGFAGPRRTLLVKSPGVRGSLEEREADGGVTPSALPYASPDAVVREWLGNIPEKPVLMTYEMADENTEVPSDGPEGPKEDSLKVLGEPSQAKQQPPEGATNEHPEPAGVLSGPGSVCCRLGGDLHPDATSGERLKAPAEAGIGEGARVDHGVSLCALPTKVAASTQIMKALLGSKPGRPSSLPEVSSTVAQRLSSSAGAFIACLARLHFFDESLGPLDGKVRLEESPKYQEMLRLFQTLWPGSELWQGQLDFSLRKLTSHQALLGTEDFTPTSSSGVDVSSGSGGSGESSVPCVMDNTLAPEKRDLPLKIPSQRPDSRNQGYPELVGHSTVSSVSQVRACATGGEETGKGGRKQTWGNAPEQSVHSTMLEGDALSEETEGRVRERLQENSVHGKGLPEEGVRVCSQEMLAAGSQDGAGSPEDTRVPTDEAGADAASGGLWPLDGREEPTESPQHFSESNSRVREHQSAHKLELGLEEVSRLDARGCKQACIKASSGTMAHKGSLDPDPIWVSKLLKKIEKAFMAHLADATAELRARWDLHDNHLLDQMVTELEQDVGRRLQASTVMEVRKIQSRAGRMVPEPPREALRGQASLQTEQRRRRLQGLRNFSAVPGQGPLSLTLEDGPTLKTALGTKSGAEPAEDEFCPCEICLKKKRTPRFPKDAATVSGAPVRKAFDLQQILQSKKGGSSNREAMEVAPQRTGRMLSQEDLGTVQGADEKQGLGVAEGEEGEGKQRLRAEEDPEILKTEGSGCCAPEEDEATEEDGEICIGTAQESQQLEGTEMGKEGTLPQSFRDGGTLEAPARQGTHSVEIQEASRERQQEVEGRHQDVKEDSPWVSSGESQGRVGSENTSLDQEGRLLNHHQRPGPQSHHTACSSRALSLDNSSQVSQKGSDGDLTSGDLKCTKAKNSRVLHAEKKVPVMYPERSSSEQEVPSSPRLPKQGKGEDEGSAGSLACTQVGGKVDGFGQDDLDF
The following text describes a protein:
Function:
Contributes to nuclear envelope stiffness in germ cells. Required for male and female fertility.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side.
Sequence:
MHSAGLLMLTVAGYFTSGIPGNTASSDVAYLTPGTYINLSENILGLQTLRTFCYPGKRLTVSSLFETVEFVLAIGSDDYSQYGGKTPEEVLQHYKDKQSLFSITLFAQKRQLLQLSPFEQQCIGISSRQAYTVILNSIPLDLWRLAQFAVGILILFSARRLAKNSVFYYLVGIVIGICASLLVVIYLAAKLFPRRTMMYGVLIGGWTIGFYVIKQLADNLRLILITYRDHVLGYLVITGLISFLICYRIGPPKNPRSQTIVMWVLQAIGAVMAYFSSWHTSAVIFIMVLVFVAHYFPISWTNQIKFMYRRRFPLKRRMLTQEEYEQQTAVETSKSLADLRKYVNSPECKQWAVMGKLRDPLRFASFANGAPHLDDEEIEDHSRTIEESMDAAPEEESVEEPEEDKPAELLPLPNSQFRYQQAARNSEPEPESESDDSEEEEFFEQEVDLRQVVQ
The following text describes a protein:
Function:
Unknown. Its expression during growth is not required for growth but for the proper initiation of development, therefore playing a role in the transition from growth to development.
Sequence:
MSSINPSLYNDNGVYCSKVIVTKAIKIRDLDQIPQTVLALAATNNGANYDYASPNYITNARKRFKARLNRNPIWYPKMGDTAAIFFARSDQAGWDIRAEVDEAILYTQKQYPHIDINYAVLTPVNTHDLVDMNLIAQLFAEDDAAAAAAANQPNQPNQGQ
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MIIHNNINFIGLKLNILNPKQIIKWSSIFYKNKIIIGEVLIPNTINFNTGLPILNGLFCEKIFDYMYKWNCNCNKKMYNINNFSFFLYCKFCKNKLIININRKYKLGFIFLNIPILHLWYLTGPLKVASLLLNKNVFYLKFLIYYKYFFSNIKYKQYFYYNKLFSKINLYKKKYKNIIQYLFSHNILYKKLQNINLLTELLNNKELLLINNKYYNKKYLYKKINLFNLFILNNIKPNWIFLDLLPILPAGLRPYFYINNSTYIISTINENYRLIILKNNKLKYWLYLRNNIFFIFEIIEKRLLQQLIDYLLINKLILKNNNTFFNFSKTFQGKYSTIKYKLLGKRVDFSGRSVITVNPSIIYNNIGLPYYISINLFKPFLINILKYNSKLNIIFKSLLINKNLFIIQKFLNRLLQNQFIIINRAPTLHRMNLQSFKPLLTEGYSLKFYPLGCTSFNADFDGDQMSIFLPLIKTSKFESNINLNFDKNIISPSNNKNLFSNLQYYKLGINTLLILNYNNELNIFYFNSIEKIYEYYNNNILFIFNLVWIKYINNNNIFYILTSINRIIINLYMYIY
The following text describes a protein:
Function:
Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as a vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation. The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen. PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase. VTC1 contributes only 3 transmembrane domains to the complex (Probable). The VTC complex also plays a role in vacuolar membrane fusion. Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation.
Miscellaneous:
MISCELLANEOUS: Present with 12074 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Cytoplasm, cell cortex. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
Sequence:
MSSAPLLQRTPGKKIALPTRVEPKVFFANERTFLSWLNFTVMLGGLGVGLLNFGDKIGRVSAGLFTFVAMGTMIYALVTYHWRAAAIRRRGSGPYDDRLGPTLLCFFLLVAVIINFILRLKYNDANTKL
The following text describes a protein:
Function:
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MARVRHKRKPVAEMNVVPYIDVMLVLLVIFMVTAPMLNQGVKVDLPKVSSEALPQDNNKQVLTLSVKADGSYYWNVGSEVDTEKQTDSAVSLEQMTDAVTKIMSARPDTQVFIRGDKAVNYGAVVGAMGALQQAGVPNVGLITEAP
The following text describes a protein:
Function:
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous:
MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTRQDLVLFRPRLALLNGIAAVAGHALVPDAAHATLWVALAGVAILAAGGSALNQVLERDLDRLMERTRQRPLPRGDLSPAMATALGCACIGTGLLVLAAGGPVPPLLGAVALAWYLAVYTPLKRRTSLALAIGAVSGALPPVIGWTLAGGAPGDYRIILLAGIFFLWQVPHFWLFQRRHADDYRRAGIPLFTPGAGRLGPSFHVRLWLGALAASVLLLPAFGLMAPRMAPWIAAVPLLLLPVCRPRSEATLFSCLNAFPPLMALALLLR
The following text describes a protein:
Function:
Produces N-formyl-kynurenine through the oxidation of tryptophan.
Sequence:
MSTELPLPVLEDYFVSAANAFLPDEFPVKELQDEYYRPWETIVSNLPALLLARQLRDVVDQLKVLEVKKELFEDMRQLRRAYSVLGFIANAYVWGYDDACDTIPESVAAPLLKVSEALGLPPLATYAGLVLWNFCPIFEDEALAGGSVWDLSNLRTINTFTGSMDESWFYLISVFFEKRGAQSMNDGLNAIRAVRSGDRAGVVAHLQALAEGIDSLGALLGRMEEMCDPYVFYYRIRPYLAGWKNMADLGLPNGVRYGDRGEYRTYVGGSNAQSSLIQMLDILLGVEHFQTGVSKTAGRSISAGSNGNGYINDMRNYMPEGHRLFLAHLQQVANIRDYVLSHNFDAELVLAYDACVSMMKSFRDRHIQLVTRYIVLQAKKKEPSTKPHATLRSGLSKHSGTMEQRGTGGTSLIPFLKQCRDETGSAAASAWGKRILYHGVLRVKDNSILDLPKKGVPVVASRSDELVNSYSEQENHLPGHW
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MGKRKKSTPKVQKKFYRLPKNFHCPYCNCEDSVHVTMDLKNLRADIHCVKCKEGVPNAKITKISEPIDVYDDWVDQIREQNKNFNPDKEEQMTEIYEDEEPIYEPSRLQSNATRSNEDKHSGDENEIENTSDDESLSDDTDSLSETD
The following text describes a protein:
Function:
ATP-dependent RNA helicase.
Sequence:
MAKKKFVENTNWKKIDTDNQLIFEQGGFLGLEEIDPNDYFLTDKNVDKIEKQQKQKQKQEQEQEQKPTNKLTTKSTTKSTPVQNKNQKPVDKKRKSKKGNDDSDNEYSGYQDDSDQDDEYSAAKKKPRIIKPTETVDMGTELLNSFVEGTVHNKKKQRKGIKVKQIIDDNDNDFEDEEEEVKPQQKLQKQKQQEQKQKQPQKQPQQPNKKNNKKELQKEEEEQMEEEKEEEEVQQEEEEEKEIKKPIKEKKVKTQKQIEAAKKNINKLEKIKKRKEISEQKTISKEEQDQLDMSEWNSYNLDPLILKGLRSLGFSKPTEIQSSVIPVAVSSGYDVIGAAQTGSGKTLAFGIPMVQRILQHLRKHGQNVENKANKQQNDNDDENEDVEEEEEEEEEEGRSKEYRKLFSLVICPTRELAIQVTNHIKSIISHTNLKVISIVGGMASQRQQRVLSKRPEIVVATPGRLWELITEGHQHLVELESLLCLGIDEADRMVEQGHFAELESILKTLPIHRTAMSKKERLKKKETEEKRNKRRKVDKLNDKGEMIKGDQDDMDDQIPDEEMEELEQEEQNHLTTTHKRQTFVFSATLVNIPGDGAPTSQKKKYRKLTPIENLIEKVRFQRDYKLIDVTQKRLTAKNLLETKIFCNLEEKDMYLYYFVERYPGRTLVFVNSIDCARRLIPIFNILEVPVFALHAQMQQKQRLKNLDRFRTLDNVVLIATDVAARGLDIPLVQHVIHYQVPRTTQLYIHRSGRTARSDQDGISVVLVTPKERPLYIKLDSSIEHDIGNFPTDIRYMEGVRDRIELAKEIDKLSHQSLKDNREKSWFKKQAEEMDIELDGDFFGENSDDEQSEDTRIAEQKKQFKLKQLRAQLKHLLSRSLLPRGVSQSYITASAIQELESKSQSSAATDFSNKAKNVIGKKAKQLAIENHSKFLTKNKKK
The following text describes a protein:
Function:
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVTKEEYGCSSSSEAIGQYTITNKHGMKAKLIDYGASLVELWVPDQHGNTADVVLGWPDLKGYENNSFYFASVVGRVANRIAKGSFSIDGVKYLLNINNGPNTNHGGIKAFHLQVWKGCIEGDDKVTFTYISPDGEEGFPGEVTATASYQLTDDNKLIISFVAMTTKATPINLCNHSYFNLAGHTAGSIIDHLIQINAENYTPLDDTSIPTGEIVGVKDTVFDLREPVKIGDRIYDVPGRGFDHNFCIKSSLEESCARVSHPGSGRCMEMFTTKPGIQFYSANYLDDTCKGKEETTYAKHGGLCLESQYYPNSVNQPNFSKSVLQPGEKYNHTTVYKFSW
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis.
Subcellular Localization:
Cytoplasm. Note=Localizes to punctate or elongated cytoplasmic bodies.
Sequence:
MASLGSAAAGEPATGAEAEPGPPAPPPPPPPPPAPSPSALGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTVDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAIVRWAEAECQRQQLAVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISVVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFLFFSSPGNNNGTSIEDGQIPEIIFYT
The following text describes a protein:
Function:
Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDNKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDTFGQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPYAIKQETPELSSSSSTPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFSHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYSHTPYASYSEAWRFPNSSLLSSPYYYSSTTRPSAPPTSATAFDHL
The following text describes a protein:
Function:
Transcriptional cofactor. Heterochronic protein, involved in timing of a subset of differentiation events during the larval-to-adult transition. Promotes hypodermal terminal differentiation, together with transcription factor lin-29, perhaps as part of a transcriptional complex. Involved in regulating molting by repressing the expression of nuclear hormone receptors nhr-23 and nhr-25 in the adult hypoderm, probably acting in concert with lin-29.
Subcellular Localization:
Nucleus.
Sequence:
MSSSSSSSLPTSSASTTTSSITSRPSASHHLESILSSSSSSPSILSSLTTQSTSSIPTSSSSSSQRQSTSNADRPVSPKPMPTPTTLSEWQLLAVLSKANLVQYYDVFIAQGGDDINQIMACEEREFLEIMNLVGMLPKPLHVRRMQRALAEYSQDQTAFNLAALQQIGPPPPLNYTPAGTDPMALLLPGIAAATSPKFPSLRFLSQLSSVAEKVSTPSEAADTSSSSPSLNLNTTSSNSVPLAFKFSTPLLESLASDQQSSSTSSVRSVLPSTSSNTSHPELPAGILPATTTNVSAAVPPPSSRATANVFSGNSIGLNFSGAASVTRHLVVPPSSTSIQQPSTSFGRSSSITGQEKEGSSSPFLGVGYSQPYGNDFVSLGDFDPNNPSLTENPTLSTAQISRLAECALAASKNLPPLPPRLVQNKKRVSKEVIELLKCSPATPSMIHAFRKYSAIYGRFDTKRKPHKVLTLHETTVNEAAAQLCLLVPSLLTRRDELFPLARQIVKDAGYNYAKSRKRPCDPADLHSPISSPGNSPPPQESEFDEQPSSSSGAFKEEERPPIPPEAWAAIIEKMKGELPES
The following text describes a protein:
Function:
Maintains stem cell potency. Involved in endocytic pathways that mediate signaling during hematopoiesis.
Miscellaneous:
MISCELLANEOUS: Marker for all hemocyte lineages during development; MISCELLANEOUS: 'Asrij' stands for 'blood' in Sanskrit as this protein is strongly expressed in blood vessels.
Subcellular Localization:
Endosome.
Sequence:
MDSPLNDGSHHPPPHAPHPLADYQFSAEEVKALRECNTESFFQRSLPFGTGLGLLAYFGVKNGYLQGHVKYGAVPKVVMGVILGYFVGKFSYQQKCAEKIMRLPNSHLGELLRQRRQGGGVISSITPDENLGRAFTLAPFSPSSADVYSDEAYQPGRSTSLNLDTESRPTLSGLDDIYRPTLDSGSMLEAELPLEPSKPGQSYEDLRRRNREEYSKHQQSPYSRPYEPPVAVQQRPVEQAQSEPAGRKNQYGDSWTD
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
Sequence:
MFQPGGDKKVLCAGLICLDILSVLDHYPVEDTDNRIERQIWQKGGNCANSAAVVAQLGEQAEFIGTLATGRAADMVLDEMREFGVEIDHVVMHDGCDFPSSTIIINTHTGSRTIIHADKDLPELTFSQFQQLDLNWYKWIHFEGRNMTEVSQMVNAVQEFNHSASMEDRIIISGECEKAKYQPEYFISTVDVLFVAKEYAQHHGFTTAKAAVHGFHSRVKKSATVVCAWGEAGADAMGPDGVHHHTDAYSPGQVVDTLGAGDTFNGAIIAAMCRSLPLDEVLKFGCRVAGRKCGQFGYRGLRE
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEHGKLVEFLGLTFDLSSVMMVTVAAVIVFLIAVIGTRSLALRPTGMQNFMEWVFDFVKGIINSTMDWKTGGRFLTLGVTLIMFIIVSNFLGLPFMYSATEAGEHIAWWRSPTSDPAVTLTLAVMVVTLTHYYGIKMKGTKEYVKGYFQPMKFLFPLKVIEEFANTLTLGLRLFGNIYAGEILLGLLAKLGGASVLGALGALVPMLAWMGFSVFVGSIQAFIFVMLTMVYMAHKVSHDH
The following text describes a protein:
Function:
Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
Subcellular Localization:
Nucleus.
Sequence:
MLDGIKIEDQFRTGAETLGVMLGADCAHHQSVCEGCHRPISDRFLLRMNDSSWHEECLQCSVCQQLLTMSCYSRDHKLYCKHDYQQLFATKCSGCLEKISPTELVMRALESVYHLSCFCCCVCERRLCKGDEFVLKEGQLLCKTDYEREKDLASPDLSDSDKSEDEDLDVKPEKGAGGQGKGSDDSKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQEQQNSQRLGQDVMSSRMENLMSSYTPLAPPPPHALVSMESSGYSTDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFMSASDAAALQSRVGNPIDRLYSMQSSYFTS
The following text describes a protein:
Function:
Required for 20S pre-rRNA processing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFDDPSKRLTYFEYAVGVLLCSWPVMKQAVEEEWADVDTADKRDWMAGVLVDYITVTSDVEAWDVEELILQVLQDEFNVGSIEDDSPYILAQDLVNVWKAACEDNYEPIREIHERLGKQLLEKEEGKEKTREESNPPVLVEDETIVDAEDGGAAQNQQEKQQGPIVDDDGFTVVQKRRR
The following text describes a protein:
Function:
Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM
The following text describes a protein:
Function:
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
Subcellular Localization:
Nucleus.
Sequence:
MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRVHGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEIDWETENHDWYCFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSHWQCPVCRSIKKKNTSKQEMSTYLRFIVSRMKERAIDLNKKGKDNKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPDNWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNIHRLHVKRSMGWKKACDELELHQRFLREGRFWKSKNEDRGEEEAESSISSTSNEQLKVTQEPRAKKGRRNQSVEPKKEEPEPETEAVSSSQEIPTMPQPIEKVSVSTQTKKLSASSPRMLHRSTQTTNDGVCQNMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRTEMEEEKRQAVNKAVANMQSEMDRKCKQVKEKCKEEFVEEIKKLATQHKQLISQTKKKQWLL
The following text describes a protein:
Function:
Might be involved in RNA metabolism; it is missing helicase motif III and may not have helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MAFQLLGLAEESGPSPGESGLAVNPFDGLPFSSRYYELLEQRRALPIWAARFIFLEQLESSPSGVVLVSGEPGSGKSTQIPQWCAEFVLARGFQKGQVTVTQPYPLAALSLALRVADEMDLTLGHEVGYSIPQEDCTGPDTLLRFCWDRLLLQEVASTRGTGAWDVLVLDEAQERSVASDLLQGLLRDAKLGNLPGDPRVIVVTDPALEPKLQAFWGNPPIVHVPRGPGECPTPIYRDSVPTDRVEAACQAVLELCQQEAPGDVLVYLPSEEEISLCCESLSREAGHLALQRPPPQVLPLHPGHGQAIQAVYQDIDSGARKVVVTHWLADFSFSLPSIRHVIDSGLELRSVYNPQIRAESQVLRPISRCQAEARRLRARGVPPGSCFCLYPKSFLELEAPPLPQPRVCEENLSPLLLLLKRRQIAEPGECHFLDQPAPEALMQALEDLDYLAALDDDGDLSDLGVILSEFPLPPELAKALLASCEFDCVDEMLTLAAMLTAAPGFTSPPLCAEEAALRRALEHADGDHSSLIQVYEAFIQSGADKAWCQARGLNWTALCQAHILRGELLELMQRIELPLSQPAFGSEQNRRDLQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQLSPYCCYRSRRAPARPPPWVLYHNFSISKDNCLSIVSEIQPQMLVELAPPYFLSNLPPSESRDLLNQLREEMADSSTGSESSSTQELGNACVLQ
The following text describes a protein:
Function:
Required for alpha-1,3-glucan and alpha-1,4-glucan production which are required for cell wall synthesis.
Sequence:
MHGLQGLCFRRAVIALALLLFHSVFAAPYSEDEEPWNLNQNKNASSVLEYSGEWADHDFFPSPDNWRMSFITVILDRWYDGDPSNNDIEKTPFEYDISEVSFRNGGDIVGLELSLDYLEGLGTQGIYIAGTPFVNMPWGADQYSPLDYTILDHHLGTIDQWRSTITAMHERGMYLVVDLTVATLGDLIGMVGHLNDTSGVDFNLNEYNAMWKTSEYRYVDFNFTNVYNTSCEYPRFWGEDGGPVSIQFKGCYVSDYDHYGDTEAFGSHPDWQRQLSKFASVQDRLRDWKPDVAEKLMHLSCLVISMLDVDGFRIDKATQMTADFIVDWSMYVRECAAKYNKKNFLIVGEVTGSSSYGSIYYNRGRQPDQRPPNVTAAFNYTSDESQYSLRDSDHYGFDGSAFHYSIYRALLRFLGMDSKMEIDFDVSSVLTTAWNGIQINEDAVNINTGTVEPLHMYGVANHDVFRWGAIENGTARLILGTMITSLLFPGIPLLYYGDEQGMYVLDNSANNYLYGRQAMNSARAWYIHGCYNGSATSYPTVDLSPAQRGCQDSWNYLDHFDIASAHRNVYRNIHSIRRHYLSLSEGWRFDHIANWTDDVYFPDSQPYASPMGLYSVLRGPMKEIQDFDSITNASNVSKSEVWVLYANRNDTHLWSYDCTDEDSAIIGPWKSGTTLRNLIYPYDTIELEDSWNSSWGCIPNIELDPYAFKLYVPEEDFIENDPIITSLTPEHDARVVASGNEIDLTIEFSRSMDCDSIKNALSVVSSTRPKNTTAVIDVDSSFCRNYSEDASTSLHGQTAGRFAWYGTLTNIDPGIHRISLKSVPTSDFSSRTLSTDNFLIRVGSTNNPIVHYSANYSDTLLIMQDGDLYINHSAPGAVLFRYSTDFQSHWSDWEEYNGGLTKVQASNWTGTRRQGWEGHHIHVQYWSDLGGSANHMQQSDYGFKYRRFLPHMFLEGDFNEYGYDSGVENRFLQKSDFYWEAGFISETYPAAIQLNVWGMNPDGIPDKTRVYGSQGNSTVLSRSDPASLVGNNITIYHPPPHGYLSYKILLRDDDMIYRLAPSGEWGVSIAIYVLCIVIPPLSAIVVSWAFKNSFYTVKFNKHGNNDLGKFYPLKSLVPFRKKNDLDSPAKVTPVVSGVSARKKKCVLIATLEYDITDWKIRIKIGGLGVMAQLMAQHLKHEDLVWVVPCVGDVVYPEAEEASPIEVKIIDQTYTINVYHHYLDNIKYVLLDAPVFRRQTSKEPYPARMDDLGSAIFYSAWNQCIAEVIRRNPIDIYHINDYHGALAPCYLLPDIIPCALSLHNAEFQGLWPLRTPEEKEEVCAVYNISQRVCTKYVQFGNVFNLLHAAVSYIRIHQKGFGAVGVSNKYGKRSWARYPIFWGLKKIGKLPNPDPTDTDEIVDDKAVAITDIDPDMEKSKVEHKRLAQEWAGLEVNEKYDLLVFVGRWSSQKGIDLIADIAPSLLESYKVQLICVGPIIDLYGKFAAEKLDVLQKKYPTRVFSQPKFTQLPPYIFSGADFALIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGWWYSVESSATPHLLKQFEQACQQALSSSQRTRARLRARSAKQRFPVSQWKAKLEALTDGCIKCSQKYGRNSRSRSSFYSLIHESFSRSSEVLPTSSDTNLDAKRAEEAEMIMIETPPTAEANTGAKLDRSLSLGSRRGPGHTTEDDASDGLDTIQEESMTAGDSTSGGSDISRYRAERLNPDSHSPSEYSFDSGDYEFDPQRSYYYDDLFDDDTTIRNAPSFRPQMGSFDAEHAVGATFSQDDLSDPARSVDSDSVSPPLPPFVAGSNPNARNNNNPYFYGNLHTESSLSLASVMSGKEKRDFSLTRVEETFTDEDGQALRSFSEKLQKLNAKNSKDDLCIEQYLMKSERSFFHERRAIKLGLQKPNKLHVNELSSHSGTEESESLSNGQTSYDDIIAMTDESNYTQLGDDDFKTIHGLKKFMLFKIYDWPIYSIFLALGQILAATAYQLTLFTGTSNIQTYEIYSVCAFFIGASFVWWFMFARLPSYYVLSIPWLFYAVALFLVGLPAFDTVAPGRVWITNVAAWIYAIASASGSIFFSLNFGEEGAVQTRIWVFRACLVQGVQQVWSAALWYWGAHLNKRLTAGEANTFKMSPAIPSITWPLSAVSILIFALLFKGLPEYYRQLSGSIPAFYKSLLRRKLVVWFCISVFLQNFWLSSLNGRSWSYLWDIGNIHQWQIFLLIVAFYIVLWALLLGVLAWISRTHSWIICVFGVGLGAPRWLQQFWATSNIGLYLPWAGYSGPYLGRTLWLWLGVLDAIQSVGIGMILLQTLTRRHVASTLMTGQIVGAVATMIGRGASPNREGPANVFIDFTKWNHGDGSSILASAPFWINIICQLAICVGYLAFFRRENLSRP
The following text describes a protein:
Function:
Involved in signal transduction through the Wnt pathway.
Subcellular Localization:
Nucleus.
Sequence:
MAASAPPPPDKLEGGGGPAPPPAPPSTGRKQGKAGLQMKSPEKKRRKSNTQGPAYSHLTEFAPPPTPMVDHLVASNPFEDDFGAPKVGVAAPPFLGSPVPFGGFRVQGGMAGQVPPGYSTGGGGGPQPLRRQPPPFPPNPMGPAFNMPPQGPGYPPPGNMNFPSQPFNQPLGQNFSPPSGQMMPGPVGGFGPMISPTMGQPPRAELGPPSLSQRFAQPGAPFGPSPLQRPGQGLPSLPPNTSPFPGPDPGFPGPGGEDGGKPLNPPASTAFPQEPHSGSPAAAVNGNQPSFPPNSSGRGGGTPDANSLAPPGKAGGGSGPQPPPGLVYPCGACRSEVNDDQDAILCEASCQKWFHRECTGMTESAYGLLTTEASAVWACDLCLKTKEIQSVYIREGMGQLVAANDG
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MRSSMFRCVSRAHYSTSVTEDFINSILARAQEATAKASSNALKLDKMKEGRMQNKRRNGNQNRNSMNNKESRGREGNQGERNMRLKNRSSDSVRANKQQWNKGANTSFVKNPTGNTVVMQPQFKKMQNGKNNLKGDARVEDDLLDVFNSSMEQKPVNFNGTPKSKARFQKKSHILTASKRRKAPQQQLQKVIKRPVSSEYVLEEPTPLSLLEYTPQVFPTKESRLVNFTLDSLKKSNYPIYRSPNLGILKVHDFTLNTPNFGKYTPGSSLIFAKEPQLQNLLIEEDPEDFHRQVTGEYQLLKPYVKKDFEKLTKSKDTVSKLVQNSQVVRLSLQSVVMGSEEKKLVYDVCSGMKPISELQQ
The following text describes a protein:
Function:
Fatty acid desaturase able to introduce a delta(6)-double bond into delta(9)-unsaturated fatty-acid substrates. Can use both linoleic acid (18:2(9Z,12Z)) and alpha-linolenic acid (18:3(9Z,12Z,15Z)) as substrates. Required for the biosynthesis of arachidonic acid (20:4(5z,8Z,11Z,14Z)).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MVFAGGGLQQGSLEENIDVEHIASMSLFSDFFSYVSSTVGSWSVHSIQPLKRLTSKKRVSESAAVQCISAEVQRNSSTQGTAEALAESVVKPTRRRSSQWKKSTHPLSEVAVHNKPSDCWIVVKNKVYDVSNFADEHPGGSVISTYFGRDGTDVFSSFHAASTWKILQDFYIGDVERVEPTPELLKDFREMRALFLREQLFKSSKLYYVMKLLTNVAIFAASIAIICWSKTISAVLASACMMALCFQQCGWLSHDFLHNQVFETRWLNEVVGYVIGNAVLGFSTGWWKEKHNLHHAAPNECDQTYQPIDEDIDTLPLIAWSKDILATVENKTFLRILQYQHLFFMGLLFFARGSWLFWSWRYTSTAVLSPVDRLLEKGTVLFHYFWFVGTACYLLPGWKPLVWMAVTELMSGMLLGFVFVLSHNGMEVYNSSKEFVSAQIVSTRDIKGNIFNDWFTGGLNRQIEHHLFPTMPRHNLNKIAPRVEVFCKKHGLVYEDVSIATGTCKVLKALKEVAEAAAEQHATTS