lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MALDFWKSSHAQQWIFDKTEIWKQRAEDMKTYSEEEYSRLNIFWANFITAVATECAHSQANVGCKLRQQVIATAIVYFKRFYLRQSFRDMCPFLVASTALFLACKVEEHTTLSVSSFLKNTALVLPKRWGVAFETNSAKNGVLYDSEFILVEILDCCLVVHHATRPMFELLEDWKQHTLTSTNTPVKDFDQIEIQCQKVVNDTLRCDVGLMFAPHCIGLASISVGMELMGRGEELEDWLVEVDTDMDKLADCINQIYTMYQLWRSFDEKEEVKKLMAKLPKPNTPIPPPQQQQSSYHM
The following text describes a protein:
Function:
Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal; Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MHYCVLRAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQRTLKSNRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRMPTQLKEYRRALQVTSPRSGQPWNWKPSPQTQISILKNPESQAVGSKQVKKLCNSIRL
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
MDLKSDCFHVGSDCLTPIAYEKGIITSKQIFKLAEKFGYHFNLLDIGGGFTAFSALETTFAKAAAVISKALQKYFPPELGVRIIAEPDFDTCSSSIQFNNAIRMERVEIVPNLSLQELIEKKTTAMDQQFKDDSFMLVNIGNIIERYREWKMRLPNVEPFYAVKCNNDPVLLRILINLGVNFDCASMAEMQLILDAGVHPDRIVYANTIKAVSHLRFAKENNINHTVFDNEDELHKIKKYHPNAKLALRICPDMKSCESRFQLGIKFGAPERDVAHLLKVARSLSLDVMGVSFHVGSDCLNPIGYEKAIIASKKIFKLAEKFGYHFKELDIGGGFTASSALEMTFEKAAVTISKALQEHFPPESGVRIIAEPGRFFPTRAYTIVLNIIGKRVVRKGNNDPFDLEHENAHLYENTSDIEKVLYYVNESVYGSIGFITLDPTLIILKPLNAGDWIYFEELGAYSLVLATEFNSFKKPKCFYYIQEEFWNEIQGKIDLPFDFYNMS
The following text describes a protein:
Function:
May be involved in DNA replication and thus regulate cell proliferation.
Sequence:
MTDMRRHSVSVDVPLSRTLVQLKRVRSLRDPATNSMSKYASPSDSMIWETASSNGAMMEGSRSAHHHLIEEDVDLEAEATMGSERSFRAPNARTASYRKSSVVRIRGFNPPRNKQVHRVRGDGHRKSVDSNHSNHSSLRQLANNIVTNVVEEKEEEEVNSYERAHLALPEKSEEEVKRRSKFKGKSSAAMSRVGSPCMSASEARSVGSRRSTVGHGTEDTRVRSNDVVGSNFSGCGISYCWSGASKYRDLYSDSDGPEQPLLSPEGTEVPFQENVPYTETPRCLSQKFRPRSFSELIGLNVVAQSLLYSSCKGKIAPMYLFHGPRGTGKTSTARIFAAALNCLSLEEQRPCGFCKECVILFSGRSRDVKEIDAAKMDHLGRVKALLKSASLVPYSSRFKVFIVDECHLLLEDAWSAIVKSLDEPYRHAVYIMITSDLDSLPRTSVTHCQKFHFPKIKVADIVNRLERICVDEGLEFDHDAVHFIAAKSNGSLRDAEIMLDQLSLLGKRVTISLVHELVGLVSDDELIELLDLALSSDTTNTVRRARELMASSVDPLQLVSQLANLIMDILSGRCQSAVTEVSKSFLGRYALADVGIEKLRHALKILSETEKQLRTSRNKATWVTVALLQFGSSESDIVAETNDMHARSATGYTDDWVSKVNSSSNFCDACNSNKSNCSERHCRRLKLENIWRRATGKCQSRSARSFLKKEGILSSVHVTEGNSEVAIAEVGFSHPDHLSRAEKMQSLIQGVLQHVLGFNVEVRFKLVPCAARKDARSKRHSFNLLGCSGRKQELSDSTVTDEDEPVRLGARETPHKGYSSSQQPSPFIVQRVDSKPTVHGSEDDARSTLTSNRSMTDDLTRTCRSETNYSKGASEQGRFDSIQEPDLQPNCFSRTLKLQKRFFSSDAAHTICFRIQPHNKMGFLPKKEFDTYFCTYGPYEQCPRSNSRATYGSRDEDLSIKTSSGFGSNLLCWKGPKQSI
The following text describes a protein:
Function:
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
Subcellular Localization:
Cytoplasm.
Sequence:
MSMFCYQCQEAAGGRGCTVKGVCGKTEDIAKTQDLIIYVVKGIAIYSSQVREIGLNTSEADKFIVESLFSTITNANFDAKALNARVQEGLKIRQSLKDAIIKAGGSYNSKENKSWTSKFLSVLGIKNDKDEKEIHDAAAWAANNPEDFKKKAETVGILATENEDIRSLRELLTYGLKGMAAYLEHANNLGYDEDSIHAFMEKALVATLDDTLSADELTALVLECGKYGVDVMALLDKANTSTYGNPEITKVNIGVRNNPGILISGHDLKDMEELLKQTEGTGVDVYTHSEMLPANYYPAFKKYKHFVGNYGNAWWKQNEEFEAFNGPILMTTNCIVTPKASYKDRMYTTGVTGFEGVKHINASKDGKKDFSEIIEHAKRCSSPKEIEKGEIIGGFAHNQVLALAPQVVDAVKTGAIKRFFVMAGCDGRMKSRNYYTDFAKALPKDTVILTAGCAKYKYNKLDLGDINGIPRVLDAGQCNDSYSLAVIALKLKEVFELEDINELPISYNIAWYEQKAVIVLLALLHLGVKNIHLGPTLPAFLSPNVAKILVENFGIGTISSVDKDIKMFMN
The following text describes a protein:
Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MTTEKSLVAEAENSQHQEQNEEGEGATNSGQQETRLEETSQAAAEGDNQCEQKLKTSNGDTPIHEDLTKNKERTSENRGLSRLFSSLLKRPKSQVSEEEGKEVESGTEKGEGGQREREFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEERREDPDFETKEEEGLEECSKIEVKEESPESKAERELKASQKSIRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLHKRVCEHLNLLEEDYFGLAIWDNTTSKTWLDPAKEIKKQVRGVPWNFIFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTVQSELGDYDPELHGADYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAIAQSQVTEGAPVKKAGVSKAQKETAEAEVKGEEVPPEQAEPEPTEVQKDLGKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTPNINGQIPTGEGNINGIRTEEVAAVTKGPSTNPDSDWEGPKHSVIPSKSQMTTPSESPQSFGFGSLSISSKETEEKEQGAAGCLDIKEIPRGPSGECVGVEDQASALEFSVSPASSQRQLAGKKAESSEEHVTPREPLGKQNGSFLDSRVGNQFPTLIRSFQPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKTITYEAAQTDDSNGDLDPGVLLSAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
The following text describes a protein:
Function:
Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
Miscellaneous:
MISCELLANEOUS: Parasitic protozoa lack the de novo purine biosynthesis pathway and rely exclusively on the salvage pathway for their purine nucleotide requirements.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAAPSATAPKHNYTLGTNASQLELYKYLKTVPPIPELRQAVTIKKYEEASVDDTLYPLIDEHQIIMVVGAFFGDEGKGKTVDAVARHPACTCVARVNSGENAGHTVFDDIGRKYVFNLAPSSLLTPNTRNYVSSECVMDPISFMEREIGQFIKSNMPYKDKLFVGNVFVVTPYHKLLDLLGSAPNSSTLKGMSPIHASKVTKRGIRLDHIFNDEGVLRARLAKDMDTYYGLLKVKGLTDKDVVRRCQEENADGVERVPGYVVDFARAENKIDYLVKLYTERVKNNKDFPRRCDVTHELRAALARGEKLLLEGPQSYWLSNAREKFWESTTSADTTAGGLLASAQFNFQRYKVLVINVHKAPGSSRVGIGANPSSFVPQDYYSAQDIKTLEALPKGGCVDFDKIQNFFYTKAFNTESKTFNGIYEPLEYEDATGKYNIGVAMSIASARHHGECGAVTKKPRVCGFFDCVLHFEVNAVQGPYLSISAVDRGDDYDRIGITIAYVYYDVGNKMVDANGRVYKNGDIIKAGDPVPCEMALYHCYPIVKVINGWKGAPIAASKRRPNEPLPKGVCEFIANVEFFTGAKVISIGNGPRGSDIIYLKQ
The following text describes a protein:
Function:
Required for pre-meiotic DNA synthesis and S phase progression. Regulates levels of meiotic intragenic recombination.
Sequence:
MNSNNKRVALQEISNYVSKSLNVKGWVNAQVREISLQNGCSPSDKHFPSQSWHGISSIEESQIQKDYDSFLASPLEEEIVFTEKQLLVDLDVCSISNVQSPNCSVSEFGIAIEESNDNCAEEDEEEELQMRYSADESVSVEYAKEILSHMEKLEIRFMPDYRHMSAQPYYVTEMRASVINWIVGVHTCINLLPESLFLSINVLDRFLSLQNVPASKMKLCGATALFIACKYEEIHPPTVKDLEIVLEGEWIGEDICGMEKYMLMVLQYQLGWPGPVSFLRLLTIVNKWESQLRIMIKYFLEVSLVEQRFSSLRASQLVATCAYTGQSILQEENWSNTLPQITGYDYMSLVSYVHLLLKCLENPFDHHYAIYSKYATPYFHGISRQVHDWIATNTNLMAMDGS
The following text describes a protein:
Function:
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
Miscellaneous:
MISCELLANEOUS: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNLLDLSYEELVTEITNLGLERYRADQILDWVFDKKVNNFDEMTNLSKKHRALLKEHFSISFLKLLDKKVSRIDGTTKFLWELEDGNTIESVMLFHPDRITACISTQVGCPVKCIFCATGMSGFVRNLTTGEIVAQILSMEKEEKKKIGNVVYMGMGEPLLNYENTIKSIRILNHKKMGNIGIRRITISTVGIPDRIIQLAEEGLDVKLALSLHAPTNFKRDQLVPLNKKYSIEEILNAVKIYQRKTGNRVTIEYVLIRGINDEISDAKKLAEILRNMKVFVNLIPVNPTVEGLRRPSRERLLTFKRILLENGIEAEIRREKGTDIEAACGQLRLKRIKSRS
The following text describes a protein:
Function:
Involved in the regulation of gravitropic response and basipetal auxin transport in roots. Involved in salt stress tolerance. May facilitate membrane trafficking and asymmetric cell elongation via SYT1. Binds stigmasterol and dipalmitoyl phosphoethanolamine (DPPE) in vitro.
Subcellular Localization:
Cytoplasm.
Sequence:
MAISHTQLLLLLLVSLFFSPALCGPKFQTCDTGKEYPLKVSSVEISPDPVKRSGNGEITITGVTNKEISDGVTVNLKLAVGMFPVSTKSYSLCDITACPVAPGPIVLTLPNIFTPREKRTAIGYTIIISITDKPLKESMMCILFVVKLTGHASMINQVTE
The following text describes a protein:
Function:
Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C-terminal D-Ala-D-Ala dipeptide. Associated with recycling and remodeling of peptidoglycan (PG) (By similarity).
Subcellular Localization:
Cell inner membrane.
Sequence:
MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS
The following text describes a protein:
Function:
NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin. Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals. In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds.
Miscellaneous:
MISCELLANEOUS: Primate DHRS4s display different stereoselectivity and catalytic efficiency in the oxidoreduction of some substrates as compared to other mammal DHRS4s due to a difference in conserved amino acid residues.
Subcellular Localization:
Peroxisome.
Domain:
The C-terminus peroxisomal targeting signal tripeptide is important for peroxisomal import. Once in the peroxisome, it is involved in intersubunit interactions; Three specific residues, Ser-176, Phe-179 and Thr-195 are conserved between primates whereas the respective residues are phenylalanine, leucine, and asparagine in the other mammal enzymes. The two residues at positions 176 and 179 are molecular determinants responsible for the stereoselective reduction of 3-ketosteroids and benzil. The presence of an asparagine at position 195 is important for the maintenance of the quaternary structure and stability at cold temperature. The absence of an asparagine at position 195 destabilizes the quaternary structure, thereby affecting catalytic efficiency toward some substrates and decreasing stability at cold temperature.
Sequence:
MHKAGQLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSQVFTSSTIPLTFESREHKEHHSIRNKPPSSPPESTDNETLQQPIWQCMLAGGFGGVVGDSAMHSLDTVKTRQQGFPYKVKYKHMIPAYSTILKEEGFFRGLYGGYTPAALGSFPSTAAFFGTYEYSKRVMINQWHVNETLAYFIAGILGDLASSIFYVPSEVLKTRLQLQGKYNNPYTKECGYNYRGLGNAIVTIAKTEGPKTFVFGYKETLFRDLPFSALQFSFYETFRQWAIYSNNGSDDLSISMELLTGAAAGGLAGTLTTPLDVIKTRIQTATNTSELSSSISTKQTITNPIIRLLNRNATLKALVSIYKHEGILGAFSGVGPRFIWTGIQSSIMLLLYQVALKQLDVLSDDKDRDKLES
The following text describes a protein:
Function:
Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.
Subcellular Localization:
Nucleus.
Sequence:
MNHLSPPPSPHSQQPSPAGLGCHGAALDKQWMQRASAFNTVIASAAAQKLNGRDLPFLYNPLLYSSALLWPQFLLSSATALGTPLTPMTPKSPASVVLGQRDRDFALTPEKEHELQMNNNNENSKQDYQEQDEDMPLNLSTKERITSDDSNRDQYHSSSNNSSRSSSSSEVEQLHPMTSLNVTPPPLSAVNLKSSSTPQQQRQRSQGNIIWSPASMCERSARREQYGLKMEEQGDEEEHQVDPIVRKFKYERRTASISSLQSPISSLSAPASNAVQDLEFEVAQQQLYAHRSAFMAGLTGNNLELLTQHLKLKSEQPQQQQQQHRIKDEQQQDNRSAAALMNLVAAAEFGYMRNQHQQPQQQQQQQLHHQQQPQQHQHQQQHPDSTATDVARRSSSSSSYQGENEEKRSGRNFQCKQCGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSSNLITHMRKHTGYKPFGCHLCDQSFQRKVDLRRHRESRHEEAPPVEDLKPLKMEVSSSSC
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MANRRHTKEGGDDRQEEGEGVVVLKKDVLDCPVCSTPLSPPIFQCKLGHLVCSPCRDKLPGKKKACSVCSKAVSRRCHAMERVVESIVVPCSNAAHGCTAMMAGGEKAEHEEACPHAPCFCPEQGCGFAGTTEALLNHFDAEHEWPVTAFKYAQPFDVPVKAGMHVLHGSEEYEEDEDDDSDLFLLHVGPPDTTMRVVSLVRVQAHAPEYDIGCSASFSWFRGQTQVATLDTIQISSLSSGVPDCRFCIVPEAPPMGDGLAFLSVTIDVDVEDDDEQEEADDEEDESEWMRRMAWVEVPANGDDEDDKADDHNDD
The following text describes a protein:
Function:
Key maternal determinant of the dorsal organizer and body axis formation in vertebrates that acts by promoting stabilization of beta-catenin (ctnnb1). Localizes on the plasma membrane of the future dorsal blastomeres in early blastulas and binds to and promotes the tankyrase-mediated degradation of axin (axin1 and axin2). Axin degradation results in stabilization and nuclear translocation of beta-catenin (ctnnb1) for activating organizer-specific target gene expression.
Miscellaneous:
MISCELLANEOUS: Was named huluwa after the Chinese animation TV series huluwa, known as Calabash Brothers in western countries.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Enriched on the plasma membrane of blastomeres only in a small region in which the dorsal organizer will form.
Sequence:
MSQLGSAVPSSNLPEGLPVSSLALLILVLIPCVLLLLLLNCLFVGYKLFRMTRRKRDRYGSEMSLMHSSYSTRQRITRFSDEPPVAPNRKTNYVSVSEPMLAPPITSSLTSSAERRATGQRAMFLRPDGATYAGSESLRVPHWRTSAPVLVQSSDSDMERVNTVPPNSPVLRVTPNGFSVPMTSLRRSSTMELESTSLDKIHVECESASIIPQENSCYVVSSSSSARGSGLDSDFGASAGVSLRILSMDSDGFPGSAWASALEWDYYDPSYVTQNHVPKHRPQAPPITTKQYWV
The following text describes a protein:
Function:
Activator of the chitin synthase CHS3 which polymerizes chitin, a structural polymer of the fungal cell wall. Chitin produced by CHS3 is deacetylated to chitosan, which helps to maintain cell wall integrity, anchor melanin, and offers an advantage during infection, as chitosan is less readily detected by host immunosurveillance.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Farnesylation is not required for cellular membrane localization.
Sequence:
MATTNAQIYQQSQMPIPMPTPSLNPNINSAPTPGPNAMSVYEDCQSPLDTSVSGMYPGDRGSRVVSQPAPLLDQSHLRPGNQANLLSHDRTIELYRENAKKTNDPELIFEFSAFMIDAAKAMIPPEQEKDTNPSPALIKQMEKREEIIKEATSLLKRLADRGFPDAQYFLADCYANGIGTARGKQDFDRAFPLFILAAKHGHPDACYRAGTCCEHGWGCRRDSAKAVSFYKKAAVGLHPGAMYRLGTAELNGALGFPRRPKEGVKWLKRSAEHATEEFPHALHELALLHERGIENVVFVDNDYAAELLAQSAELGYAPSAFKLGECYEYGKMGCPVDPALSIHYYNISAQQDHKDACFALTAWYLVGSPGVLPQSDTEAYLWAKKAAELGLAKAQYAVGYFTETGIGIEANPQAALTWYKQAAEGGDKRAAKRLATGSRSSALDRRLEMEALKEEKRLGAANLAQRSGSGSGASGKDGKDGCLIM
The following text describes a protein:
Function:
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Subcellular Localization:
Cytoplasm, P-body. Nucleus.
Sequence:
MSTPAAAPDHQKKKHRGARRRNAAASNPPKVETQSTNPPQTGRASQASNLLAQLAAAQGSTIPVSQPSTSRVPSIPKAKEINNKHQKQPRCYNRGKSVGARMSAKHPPPPAPSSQRNRTTSQGTYKQSDTTTYRGPKVPEDVLDIISFRFLMNVPDSERLDETRICFQIELAHWFYIDFYVNQDERADCVNIGMRDFVKVMFAHNDFLKQLTYRSDEILDNWRSYKSTVPTYGGILMDSSLNHILLVQGFYASKNSWGFPKGKVNQMEIPRMCAIREVLEETGFDFGEHSDGNEFKIQKMVNDTMIRLYIVKDVPMDYKFEPQTRCEIRKMKWFNIWDLPLDRNDQVAASNGFHPKNFYGVVPFVQDIQNYVKREEKKREKEGKNKKGVPLNDGKKHSAFTKVEKKSPTDRLWMGDVSMGSNSETIHFEGVETPTTYETLFKPLGETGGAPPGSNLAMILAHSSAGSTPRNASTSKASVAHPVAIRPCDHPVYEAPVKEDKCKVASNLIANVWSPAPTSSSHSATHIENTLNKLLFNAPIECVSLGMDRSKTPIQRDSSVDGDEEVKECVPTLSQEPSLPPLGDLCISVEGVYPTGLVDLPSTSSQTHSHSSSTFRRHSVSSSILSPAIKNRCAFELVPAWKSFKLNREQIFKEIASFFM
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MEGQGVGRTLRLLRNRLPRLRAGQSQNNPGEAVTEPERIQEHSPSSFAGGQHFFEYLLVVSLKKKRLGDDYEPTITYQFPKRENLLRGQQEEEDRLLSAIPLFCFPDGNEWAPLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPQLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSVLLHCLHLEQIIQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFLQEVMDSPMEEVLLVNLCEGTFLLSVGDEKDILPPKLQDDILDSLGQGINELKTSEQINEHVSGPFVQFFVKTVGHYASYIKREASGQGHFQERSFCKAVTSKTKRRFVKKFVKTQLFSLFIQEAEKSRNPPAGYFQKKILEYEEQKKQKKSRERL
The following text describes a protein:
Function:
Involved in microtubules reorganization during spindle and phragmoplast development.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Preferentially localizes to microtubules minus ends.
Sequence:
MSDVTGDLAAVSEAKGGSDAARISEVKAWLTSQFEAVGKEVPNFEYTHRSITHLYNLATASQAKSQAATIVANDFRLKASEYRAQAARIREILESAGMSQESLPSNVVSSAQVLANVANLLNIRDTELSSFLVAMGDISLRKTGVEEKRAKAQKESNALLDYTRKAIQRLTYLKKILAQLEDDVVPCESQMENWKTNLEVMAVKEEQYIQQYKKYEQMLLNRVGYTPKISHRELVEMAEHRKELDKMTKPVLDTLRSYQDLPPDKALAALAIEDKKRQFTAAEKYLEEVLQSALETNDE
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of adenosine to produce inosine. Unlike mammalian adenosine deaminases, also catalyzes the deamination of 5'-methylthioadenosine (MTA), a by-product of polyamine biosynthesis, to produce 5'-methylthioinosine (MTI). Plays an essential role in the purine salvage pathway which allows the parasite to use host cell purines for the synthesis of nucleic acids (Probable).
Sequence:
MNCKNMDTSYEIINYLTKDELDIDLSCMDKKERYKIWKRLPKCELHCHLDVCFSVDFFLNVIRKYNIQPNMSDEEIIDYYLFSKPGKSLDEFVEKALRLTDIYIDYTVVEDLAKHAVFNKYKEGVVLMEFRYSPSFMSFKHNLDKDLIHEAIVKGLNEAVALLEYKIQVGLLCTGDGGLSHERMKEAAEFCIKHKKDFVGYDHAGHEVDLKPFKDIFDNIREEGISLSVHAGEDVSIPNLNSLYTAINLLHVKRIGHGIRVSESQELIDLVKEKDILLEVCPISNVLLNNVKSMDTHPIRMLYDAGVKVSVNSDDPGMFLTNITDNYEELYTHLNFTLADFMKMNLWAVQKSFVDPDIKNKIISKYF
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MLFTKELSFAMVLLVHLVQAVPVVNLVNMPDTELCALIRNGTNVAFAMEEAEKCNDTQDDLGAGCPSVECDNSLLCSNGYLLDAEGCETCECIEWARDMEMDITGDFDDIDVWKDYTDELGEFVITYETSEYLTEKKAITQAIDEINENTCLQFLPRKINDSKENYIRFEWDEVCSSAVGKTGGAQGVILSEECSTKGGVLHELMHTLGFLHEHNRPDRDQYINIEWENIIPEKRSMFNKWQVSEDGVLNEFPYDVSSVTHLDSFAFSNNGEPTITGLDGFPLPTQNTHLSVLDIDKINHVYGCPEFMPLPPMMPDKCKDDLFACPELANTCACLLSPAFMMNHCCSSCEMEATQIVDHFPFCNLWAANCGKSRYFDNLCRKTCPKCVLAG
The following text describes a protein:
Function:
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
Subcellular Localization:
Vacuole, aleurone grain membrane; Lipid-anchor, GPI-anchor.
Sequence:
MASRILYAAAVVAAVAVSSLAGVAYAADAPAPSPTSGAAAVSSSLVAAVLCPAVALLLGNLRQ
The following text describes a protein:
Function:
Transport system for both nitrate and nitrite, with much higher affinity for nitrate than for nitrite.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLKKLFSFSDRYRILHQTWFAFFLTFVCWFNFAPFATTIGKELHLAPEQIKTLGICNLALTIPARLIIGMLLDRFGPRITYSILLMFAVVPCLATALAQDFNQLVISRLLMGIVGSGFVVGIRMVAEWFQPKEMGIAQGIYGGWGNFGAFGAEFALPILAISTSFFSGGASNWRLAIALVGIITAIYGVIYYNTVQDTPRGKVYKKPKKNGSLEVTSIKSFWAMMISNFGLIFALGLLAWRLEQKKIHFLTLSQMYLTWLVLAGLFAYQSYKAWQVNRELLTGKKTYPVSERFQFGQVALLEFTYITNFGSELAAVSMLPAFFEKTFGLEHVVAGMIAATYPFLNLVSRPSGGLISDKFGSRKWTMTIISVGIGVSYLMAHFINSNWPIPVAIAVTMFAAYFAQAGCGATYSIVPMIKKEATGQIAGNVGAYGNFGGVVYLTIFSLTDAPTLFSTMGIAALICAFMCAFFLKEPKGSFAPAYEGEASETATKSSVFLTEE
The following text describes a protein:
Function:
Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MASVTEQVGEVLLGTTEEPQLSQLTRAAFMKHAQKDEATGEYFLTEDQFIDAVAPESEDYHKIKRYQYGILFAVADRDRKGRVTIHDWSVFQNLLAKPDAEYEVVFRFFDKKRTGYINFDEFYETWKAHKTEGSLPFNWEGEWAALYIGSKKHRHAMTYPQFAQMLRGLQGERVRQGFTHFDSDKDGFIEPEDFQRIIRETASHKLSDYLLENLPTLCNISVGSKISYANVRAFQNMIQQMDMVELIVRNATLKSGDGKITRTDFLNEAARLSRFNLYTPMEADILFHFAGLDEASGRLSLRDFARVLDPSWHSAASLGAEAVSEAGQKVFAKSKSIWHDVLESVHHFALGSLAGAFGAFMVYPIDLVKTRMQNQRSSGAGHVLYKNSLDCAKKVIKNEGFTGLYSGVLPQLVGVAPEKAIKLTVNDLVRGKMTDKSTGQIRLPHEILAGGTAGACQVVFTNPLEIVKIRLQIQGEIAKNVEGAPRRSAMWIVKNLGLVGLYKGASACLLRDGKSQRTHNHLKKDFFGESPQKSLGVVQMLTAGAIAGMPAAYLTTPCDVIKTRLQVEARKGEVSYNGLRHAAQTIYRQEGFKAFFKGGPARIMRSSPQFGFTLAGYEVLQRGFSEATAPLPYLRSRNALKVILDLDENFGRPKMPAKWTGIPGFSGKPNA
The following text describes a protein:
Function:
Necessary for normal cell division and for the maintenance of normal septation.
Sequence:
MIIRDVELVKVARTPGDYPPPLKGEVAFVGRSNVGKSSLLNALFNRKIAFVSKTPGKTRSINFYLVNSKYYFVDLPGYGYAKVSKKERMLWKRLVEDYFKNRWSLQMVFLLVDGRIPPQDSDLMMVEWMKSLNIPFTIVLTKMDKVKMSERAKKLEEHRKVFSKYGEYTIIPTSSVTGEGISELLDLISTLLKEN