lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDLREKHLGEPPLALGLSTRKALSVLKEQLEAVLEKHLKERKKSLTWKEAWRSSFLHLSNRCSCFHWPGASLMLLAVLLLLCCCGGQPAGSQGVELVNASALFLLLLLNLVLIGRQDRLKRREVERRLRGIIDQIQDALRDGKEIKWPNSMYPDLHMPFAPSWSLHWAYRDGHLVNLPVSLLVEGDIIALRPGQESFASLRGIKDDEHIVLEPGDLFPPFSPPPSPRGEVKRGPQNPQQHRLFRVLETPVIDNIRWCLDTALSRPVTALDNERFTVQSVMLHYAVPVVLAGFLITNALRFMFKAPGVTSWQYTLLQLQVNGMLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAKFSEDTLSSYTEAVSSQEMLRCIWGHFLRVIQGTSPTLSHSASLLHSLGSVTVLCCVDKQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDDLSTRSFCHPEVEEEPHEHDALLAGSLNNTLHLSNEQERSDWLADGPKPSEPYPHHKGHGRSKHPSGSNVSFSRDTEGGEEEPSKAQPGTEGDPYEAEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQSHLTSLKPLGLNVLLNLCNASVTERLCRFSDHLCNIALQESHSAVLPVHVPWGLCELARLIGFTPGAKELFKQENHLALYRLPSAETLKETSLGRPSCVTKRRPPLSHMISLFIKDTATSTEQMLSHGSADVVVEACTDFWDGADIYPLSGSDRKKVLDFYQRACLSGYCSAFAYKPMNCTLSSQLNGKCIELVQVPGQNSIFTMCELPSTIPIKPNNRRSSWSSDEGIGEVLEKEDCMQALSGQIFMGMVSSQYQARLDIVRLIDGLVNACIRFVYFSLEDELRSKVFAEKMGLETGWNCHISLTPNGDMPGSEIPPSSPSHAGSLHDDLNQVSRDDAEGLLLLEEEGHSDLISFQPTDSDIPSFLEDCNRAKLPRGIHQVRPHLQNIDNVPLLVPLFTDCTPDTMCEMIKIMQEYGEVTCCLGSSANLRNSCLFLQSDVSIALDPLYPSRCSWETFGYATSTTMAQASDGLSPLQLSGQLNSLPCSLTFRQEESISIIRLIEQARHATYGIRKCFLFLLQCQLTLVVIQFLSCLVQLPPLLSTTDILWLSCFCYPLLSISLLGKPPHSSIMSMATGKNLQSIPKKTQHYFLLCFLLKFSLTISSCLVCFGFTLQSFCDSARARNLTNCSSVMLCSNDDRAPAWFEDFANGLLSAQKLTAALIVLHTVFISITHVHRTKPLWRKSPLTNLWWAVTVPVVLLGQVVQTVVDLQLWTHRDSRVHFGLEDVPLLTWLLGCLSLVLVVVTNEIVKLHEIRVRVRYQKRQKLQFETKLGMNSPF
The following text describes a protein:
Function:
Ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
Sequence:
MSGGKVSFKVTLTSDPKLPYKVFSVPEEAPFTAVLKFAAEEFKVPPSTSAIITNDGVGINPQQSAGNVFLKHGTELRLIPRDRVGCVC
The following text describes a protein:
Function:
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. Acts to promote CASP3-mediated apoptosis. Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1. Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4. Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade; [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells; [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; [Isoform 1]: Cytoplasm. Nucleus. Mitochondrion; [Isoform 2]: Cytoplasm. Nucleus. Mitochondrion; [Isoform 5]: Cytoplasm. Nucleus.
Sequence:
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGSNATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPVSRKLSTTGSSDSITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVSVGPGVTSGVNVNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQPTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVETVKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQQQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSISQSQISQVQLQSQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVAQGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQSLAQAIGSQIEDARRAAEPSLVGLPQTISGDSGGMSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGPTA
The following text describes a protein:
Function:
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval immune response: required both for the phagocytic degradation of internalized bacteria and for the induction of Defensin in the fat body. Within the phagocytic blood cells, has a role in detection of infection and activation of the humoral immune response.
Subcellular Localization:
Lysosome. Note=Blood cell lysosomes.
Sequence:
MAQQQGMDSALFERRLRPVYDNLEVGNNRKALQESEKLLRKHPNLLCARALKGLSLLRLGRYDESHGCLQTVAEEKPTDDSTLQVLSFCYREMEQLDKIVELYQHAVKQNPGNEELLAHLFISHVRVEDYKAQQAVALQLYKAQPKNAYYFWSVISVVFQGIRGPESALPEKRKIYLGLAQRMVDKHIKEGKMETEQEAFLYLHILKLQNKYQEAWEFLTGELCAKLYPGAPVSMKFELLKELGNWRELNELLQQLLDADRDRWDFYKEYIQSSFELLKLTPQGVENGDKDSLARCQEFLQRIIDSSERKKRGPYLARLELHQRMRAEQLPAEKLIGDFDEMVIEYFRLFGDKSCCTHDIALFLPSISMNQRQALASKLLLESGVTSTSLPKNKEQLQKHLCALQISRMCGSHMDLPADHLLAFYTALKLHYEHGRTTFGKKLLATEMGPSDAYALLAANVMYDLSRRENKSDHLFEALCLLQYVLRNSTSNFHVKLLSLKIYHLFGCQVGAQEMYEYLDIKQIQLDSMGYVHCQLLALGGRFSGNRNVYDATLKFFTNSYKERLEYIALTYRFCTFSKMEEFMNFKERLTNSLQYVACSVEAQICDLVSCYGNITQNLSAYVAMSIEPAEDRIAWHELSDNRDLGAIIRWDPLHEVDAAEERRESFDQEVEVLQVRSLMLRLFASFIDLYHGAGLKDSPAGAETATLELLRESWTGLFQRLRVMNYKPLAQKFLVNLLPTRLHLLLDMPYERFFDDLAQLVLDLQSGSAKLAEQCKRVGDNVIATMELCVQTINESNESNGIDGLWKRRGQQQKVAASLEMLSLYAFLLSVLNDKLQVSSKTKTKKKPVENKVDGPQPISEKERSQMLQELMRQLKHKFEACDTAIRSWKAPVLPRDLSSFMSDMSLKPEVEATLIGDVSATFKDSHELMVTELRNLLKDKIRMVAK
The following text describes a protein:
Function:
The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
Sequence:
MAEVLVYVDHVDGAVRKPTLELLTLARRVGEPVAVALGGGAGDTAATLAEHGAAKVLTHEAAEYADYLVVPKVDALQAAVAAVSPAAVLVPSSAEGKEIAARLALRLGSGVITDAVDLEAGDEGPVATQSVFAAAFTTKSRVSKGTPVITVKPNSAAVEAAPAAGAVEALSVTFSAAATGTKVTSRTPRESTGRPELTEAAIVVSGGRGVNGAENFAIIEALADSLGAAVGASRAAVDAGWYPHTNQVGQTGKSVSPQLYIASGISGAIQHRAGMQTSKTIVAINKDAEAPIFELVDYGVVGDLFDVVPQLTEEVKTRKG
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Subcellular Localization:
Secreted.
Sequence:
MKATLLLLLLFAVILPGTISAEQEKPGSCPNVDMPIPPLGLCKTTCSKDSDCSETKKCCKNGCGFMTCTTARP
The following text describes a protein:
Function:
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
Sequence:
MSKPIEIEIRRAPVLGSSMAYRETGAQDAPVVLFLHGNPTSSHIWRNILPLVSPVAHCIAPDLIGFGQSGKPDIAYRFFDHVRYLDAFIEQRGVTSAYLVAQDWGTALAFHLAARRPDFVRGLAFMEFIRPMPTWQDFHHTEVAEEQDHAEAARAVFRKFRTPGEGEAMILEANAFVERVLPGGIVRKLGDEEMAPYRTPFPTPESRRPVLAFPRELPIAGEPADVYEALQSAHAALAASSYPKLLFTGEPGALVSPEFAERFAASLTRCALIRLGAGLHYLQEDHADAIGRSVAGWIAGIEAVRPQLAA
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Sequence:
MKFSASILAVAIAAPLSVSAFSTAFSRGAAKSAVSSTSVSRKSSTHFSSCACPSCITFHSRSCACSSCTGSHPANCACFSCSGGFALRMSEAVVEEVPVEVEALDGVASDEEAHNVDRPARASGIHKHKEGGKQRTALADLEIGASVEATVKTITAYGAFLDIGAKSDALVHVSRLSDDFVANVEDVVKAGEKITVRIVSVDTEKNQIAVTMRSEEAEASAARPTKRRERPQRSGADQTSQAASIKAISDKGFDDSKFIDGEVVSTLAFGAFVRFDSAQLGEGLEGEVDGLVHISALAEGRTANVSDVAAVGDKVSVRVRSVEPEAGRISLSMITKEQEEAAPPARTERRSGGGGREVAPIANSWKDTGAGDWKETMDEFTKDQPTFTNTAVIQDRRK
The following text describes a protein:
Function:
May be involved in cell migration.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDQVSIEMSSTPRPTMVKSKSQLSLRRSLTITFKDLAYSVTVKKKKMQILKGVSGTVTPGELVAVFGPSGSGKTTLLDILANRKESGEISGAVLINGNEIDDDYKRLCSYVVQEDVLLPTITVRETLRFYADLKLPKSWTEKEKHERIEQILEQIGLSHRADAKIGGVLPGGIVLRGLSGGEKRRVSIGCGLVTSPSIVLLDEPTSGLDTTSAMAVMKTLVELTQQKSVTVICTIHQPRSEIFKLFTKIMVLAEGRLVYYGNRPVEHFTEIGFPFPDQTNPADYILDAVTTIKEEGRADEIADRLQSSYLDQANQESSSTLTQSQLGIINASGKRKINAYNNGLFTQFLVLWKRTGLDFIRNPSNCLVRFAVAVFVGLLFGACFSGLGMDEKGVQSRSAVLFYLVINMILQPFASISLFISKRTLFNAERASKLYHTLPYYLALMFFEILACIGTAFILGTITYWFADLNPGADKYFFAMAILTLAHLAGDFFMLIISCITVQVDTSFAVGAGVATIYQLFAGFFVPINALPKSFEWLHWCNFVYYSFEALMHNEFVGETVNCGQLACPTGRDVLINLGLNNRGKGINLIIVSSFAFAFFTMVFLCLHYFHREKR
The following text describes a protein:
Function:
May play a role in cellular stress response.
Subcellular Localization:
Cytoplasm.
Sequence:
MDQKCKELILSSGEPLIFRNYVNWGLVKWKLDDWSNLLKNEELVFRCGKKAFTQEPQWERATRIKKTTFKEFISFTESDNNSWMYFDYKYLKDWFKNTKELKKEVNWSLFGFPELSSEDSTIWIGSAGAHTPCHIDTYGCNIVVQIHGRKQWILFPPDENLKPTRIPYEESSIYSKLNFFSPMITDFDGICELRVVLEPGDALFVPHKWWHYVENLDTAISINVWLPLPEDHEERFREALVQFFITQVTQNLDLETKKAILNPNSDQACSPKFLQIFINNFYRKLGTLLWMHL
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKPTEIKKPYRMEEFLRPQMFQEVAQMVHFQWRRNPVDNSMVNASMVPFCLSAFLNVLFFGCNGWDIIGHFWLGHPANQNPPVLSITIYFSIRGLMLYLKRKEIVEFVNDLDRECPRDLVSQLDMQMDETYRNFWQRYRFIRIYSHLGGPMFCVVPLALFLLTHEGKDTPVAQHEQLLGGWLPCGVRKDPNFYLLVWSFDLMCTTCGVSFFVTFDNLFNVMQGHLVMHLGHLARQFSAIDPRQSLTDEKRFFVDLRLLVQRQQLLNGLCRKYNDIFKVAFLVSNFVGAGSLCFYLFMLSETSDVLIIAQYILPTLVLVGFTFEICLRGTQLEKASEGLESSLRSQEWYLGSRRYRKFYLLWTQYCQRTQQLGAFGLIQVNMVHFTEIMQLAYRLFTFLKSH
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSKSVIESTAGSTPSSTTGSNPSSNPSSTPGSTSIPHPFRFSSSKLSIYDSPELQCPTKPTTTPHDSSPYRTFSTIRTLATFQDKPNDLELLIRDARLETTKAFASTRVQAQGIVNHWLALEKSAQDVVGTYHEPTEDYIPGLIYVTIAGFAGSILAKNSNILVGLLAPVAGSMGAFAYYFPTTLQNIAMQRHASTATPFKIGNLSVSEYTCSVLDKAASTLGITLPWTTSEKK
The following text describes a protein:
Function:
Binds to actin filaments and promotes cross-linking into thick bundles. Has an actin-stabilizing activity. The actin regulatory activities are not regulated by pH and [Ca(2+)].
Miscellaneous:
MISCELLANEOUS: Cross-links actin with a constant of dissociation of 0.5 uM.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSFTGTQQKCKACEKTVYAVELLSADGVGYHKSCFKCTHCKSRLQLSSYSSMEGVLYCKPHFEQLFKESGSFNKNFQSPAKSADKSTPELTRTPSRVAGRFSGTQEKCATCSKTVYPIEKVTVESQTYHKSCFKCSHGGCPISPSNYAALEGILYCKHHFAQLFKEKGSYNHLIKSASIKRSAAAAVAAGVPAASVPES
The following text describes a protein:
Function:
RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2. May be involved in cellular senescence.
Subcellular Localization:
Cell projection, dendrite. Perikaryon.
Sequence:
MEEAAPSVDHLDEEEAKDLDFYGFEPLPTLLEDEENVSLADILSLRDSGLTEQDIWAICLECSYSMKSISNSSIFQTLCITPDTLAFNTVGNVCFMEQLSDDPEGAFVPPEFDITGNTFEAHIYSLGATLRAAVEYVREPELAPQFTQDLEALLDQMQEDNPGHRPDIESIISLCEEKMKLASSCNICQSLSAVGRRVLSIESFGAFQDVNDSIWRGKMSQKNMGPKLKPNEKTTSDLSSAEDVSLNCLTGVVLKDREGDRKEGGISFENRSPPLKARLETLVKNGEKDDQERFTSFILDSKYYASDPDRDFLKKSRLRKIQTFPKLPIEAPEANNFCVSVASSGSLSKKGQFPISELFPLEKKSCPVEKNGPSGIKAQTKLKSDVRDGLRVEVPLPCEEATVESKGDRKAGSAGNMGKGGAGPNGETLRECGPQNDPIQILEGEDGSAGIPGNELTSLTGTNLDEQLSPLNQIPPPQSSNSWMAQPDSEGNSESEIISNEQRISLQDLLSQVVRPFKEYELWALCHECLSTLQSYTDYPAYLCLDSVLIDADGNVLFDTPKEGGPYNSFYLAPEIEEEKVVTEKASVYCVAAILWTAAKYNFPLNHKLALPRKLKRLLLDMAKSDSDERPSIADAIKTCSGYLLQRGMNGKKVLAHLSSSTCKQVYPEEEVISLQNAFSVVEFKNKSNKLFSSDSPSGFVPSTNESKLIAVKGPIPCRFSPYKETSELPDAFTSSATHFKPIIIAQTTETTKENHASTLSQPESPEGEEFDFSNKKGIFVGDIENRASEDQLATLNKKTQDMPSSAPDIKSSTQAVPKEETPGSVPKEDSPSPLISSDSQREKSLSISSDSSACPTLPAPTLINDFLSKQEQKLKEIGQDPREQLSNQQPPPDKKAKSPMSSSVSQGTLGKNLQNRSSKLPSGENADAPDQGEENHGLMVQTRVEKGSDKMMLGSALPSPGCGRPANQNPVRPPNLEISSPQNRMICPSLQRAVRLIQEEFAFDGYLENGLEVLIMGEYIFGLKDLTYATFCGAISEKFCDLYWDEKLLQNLFDVVNGKTSSPLGTSENVGSQWEQTTQNMKKSGSLPTGRKLIKDGIGKERRVTTAHANIALSPSPSFVEMDSSDLSQSNFEVGFRPQQTRPEKELYSLDDICSPTHRGLGPELDQEDAENDGATAMVEADDNRNSPHPCPTEFQSCSPGWGSAFYEVDCFSSEVYNYVKKLGRQKGNEPQNLDAKNLKPLLDRECNQELEQQLMIEKKNYRKTVKFYQKLLQKEKRNKGSEVKTMLSKLKGQLEEMKSKVQFLELVKKYLQVMYPEQWGLEPCALPVIVNIAARCDTDFSPLDESSSLIFYNVNKHQSNKQKRSRILQAGTPLGLMAYLYSRDAFFEGYVQQFIYTFRYFCTPDDFLQFLLDRINSTLSRANKDPSSIFTKIYNRSFCILQAWIEDCYTVDFTRNTGLLDKLEGFISSKIAPLDRYGEQLLSFLEVTTDKKCDGMSRDCTLEDLKEADSDSKSLHTLCKKLSEDNVSRKSFNWKLYKGNGFIMPHHKERQYTIASALPKPCFIEEFYGSYTKTNEKGPYFLTEYSTHQLFSQLTMMQQELFQKCHPVHFLNSRALGVIDKSATIPKAASTESLSGKVGSLFLPNYIQDKYLLQLLRNADNISTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILGGLEHLIVRQLPAWKILPAKVAEIMEELKAVEVFLKSDSLCLMEGRRFRSQPTLPSAHLLAMHIQQLETGGFTMTNGAHKWSKLRNIAKVVSQVHAFQESPYTFAVDHKLQSYLKQRIARFSGADVSILAADNHTNFHQGPGEKHSRKIQDTLRRMKATFQ
The following text describes a protein:
Function:
DauR represses the dauBAR operon.
Sequence:
MSPSQDPSLENYRAIADGIATLFFPHAEVVLHDLRSQRVDYIANNLSKREVGDDSALEDMLEGDSDERNIGPYEKLNWDGQKIRSVSTVLRDSAGQPLAVLCINLNISLFESAKAALDLFLSPSKLIPQPDALFRDDWQERINTFLHGWLRQRQLGLNLLTREHKRELVLALHAEGAFKGKSAANYVANVLNMGRATVYKHLKELKEGGD
The following text describes a protein:
Function:
Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini. VP2 is required for the replicase activity of VP1 polymerase (By similarity). Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles. May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication (By similarity).
Subcellular Localization:
Virion. Note=Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (Potential).
Domain:
The N-terminus binds RNA (By similarity). It is necessary for encapsidation of VP1 and VP3 (By similarity). The N-termini of 10 VP2 molecules form a cylindrical hub underneath each 5-fold axis of the inner capsid.
Sequence:
MAYRKRGATVEADINNNDRMQEKDDEKQDQNNRMQLSDKVLSKKEEVVTDSQEEIKIRDEVKKSTKEESKQLLEVLKTKEEHQKEIQYEILQKTIPTFEPKESILKKLEDIKPEQAKKQTKLFRIFEPRQLPIYRANGEKELRNRWYWKLKKDTLPDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETASICDAIFQDEETEGAVRRFIAEMRQRVQADRNVVNYPSILHPIDYAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIVNTIIYPAFGMQRMHYRNGDPQTPFQIAEQQIRKFSGSGIGWHFVNNNQFRQVVIDGVLNQVLNDNIRNVHVIKQLMQALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETLMACVTMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKAIVEDFLKRLHIFDVARVPDDQMYRLRDRLRLLPVEVRRLDIFNLILMNMDQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPVALVGALPFVTDSSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVPTSTTKVYKQVPQQFDFRNSMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA. Unable to interact with the cap-binding complex and is therefore unlikely to be involved in translation initiation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSERVSEEPGLDKGDGAEECELDDPELKAIRMRVREMEEEAERLKGLSGQDKSIGVSPRPCMKLIHSKMTAGEYTEGPPRPLSAEEKKEIDKRSVYVGNVDYGGTAQDLEAHFSSCGSINRITILCDKFSGHPKGYAYIEFAERNSVDAAVTMDETVFRGRTIKVLPKRTNMPGISSTDRGGFRGRPRGNRGNYQRGQRPRGRPFRGCGRPGPLNHPY
The following text describes a protein:
Function:
Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA.
Sequence:
MTVPTYDKFIEPVLRYLATKPEGAAARDVHEAAADALGLDDSQRAKVITSGQLVYKNRAGWAHDRLKRAGLSQSLSRGKWCLTPAGFDWVASHPQPMTEQETNHLAFAFVNVKLKSRPDAVDLDPKADSPDHEELAKSSPDDRLDQALKELRDAVADEVLENLLQVSPSRFEVIVLDVLHRLGYGGHRDDLQRVGGTGDGGIDGVISLDKLGLEKVYVQAKRWQNTVGRPELQAFYGALAGQKAKRGVFITTSGFTSQARDFAQSVEGMVLVDGERLVHLMIENEVGVSSRLLKVPKLDMDYFE
The following text describes a protein:
Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMCIYWLRQRQAPSSDSHHEFLTLWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPVTLGLLVAGVLVLLVSLGVAMHLCCRRRRARLRFMKQFYK
The following text describes a protein:
Function:
This protein binds directly and specifically to 23S rRNA (By similarity). May play a role in plastid transcriptional regulation.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAASLSFFSSSIFLSNPNIQSSKHLLFRSPKQLSVAAIATIRSEVATIPILSFDGAEVGSTTLNLKSAPLDTARAVVHRGLTTDLRNQRRGTASTLTRSEVRGGGIKPYPQKKTGRARRGSNRTPLRPGGGVVFGPKPKDWSVKINKKEKRLAISTALSSASENTIVVEEFNDKFEKPKTKEFIDLMRRWGLDPKEKSLFLMTDVSDNVILSSRNIGTLKMLTPRTLNLFDILDSEKLVLTKSAVDFLNERYGDENEWEDEEEDDQEDNDGGEAEESTESSE
The following text describes a protein:
Function:
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus, nucleoplasm.
Sequence:
MLTPAFELTQDRDFLTVAIRVPHARASEFDVYFEGVDFKFYAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLAPRKSRSAKPLVEEIGASGVSEEGADDEDEEFDWEIEQTPYEEVSESTLRSQCHYGFGNLRAGVVQRLQDELSEVIDIKDPDFTPVTERRQKRLAAELAKFDPDHYLADFFEDEAVEQVLKYSPWWNDVHTEMMASLGKSQEQGDAAALVSFSEEEKYQLRKFVNKSYLLDKTAHRQVYYSLVDILLAYCYEVRVTEGEHNTWTDVHEILVSFGRRVLCYPLYRHFKLVLKAYRDTLKILQLGKSAVLKCLLDVHKIFQENDPAYILNDLYISDYCVWIQKAKSKKLAALTEALEAVSLSKAQLGFELLELEAAAILVQEEETAGKTAQCSPTEQVPHSSPEPSDSDSTSSSDTEDSASVQEELVGTQPSLLTSLQVPLLEEDSALTIRDSGLCRNMGSQKCEVRQGQPLASPRAPLIEEVGDSGLCRNMASQGCEVSQEQPLASPRAPLIEEVGDELKTMLWVSTPSGVNAGSHRSVQDAEERDQVPCD
The following text describes a protein:
Function:
Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Sequence:
MLIKEYRITLPFTKEEYRLGQKYMTARKTHESSNAGDNVQLLEKSSFTDKNGVKGTFTHKVFLLKKSLPRYASAILPKSALKIEEKSWNSYPNTKTIYSCPFFGEKFYLCIESIHKDGRDEEENVFGLSKDILKKRIVDHVDIARDEVEGKDVKTDEDPRMFKSKLTGRGPLTSPNWRKEVNPAMVVYKLVTVNFNYWGFQNRVENLVQTNGLREVFLKAHRSLFCWMDEWIDLSEEQIEQFEQSTYQLMMNNTIENKLNEDIKNMNISEKKGNQQNTYSKGDFKCPNVNCQHVCSECKHMLMTTTTTTTKTVTETTTTVQSPICYRNMVC
The following text describes a protein:
Function:
Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane. The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier. May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta. Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate. Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTKAEMGRFNISPDEDSSSYSSNSNEFPYTYPTKQAALKSHYADVDPENQNFLLESNAGKKKYETEYHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFVILLAFVSIFSLYSVHLLLKTANEGGSLLYEQLGQKAFGMAGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALMSIEENKGEWYLNGDYLVLLVSLLLILPLSLLRNLGYLGYTSGFSLLCMVFFLIVVICKKFQISCPFETEMVNETVNNTFMHLAESQTSALEVNVTEEDTCKPHYFIFNSQTVYAVPILTFSFVCHPAILPIYEELKGRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYGNVEPELLHTYSAVMGADILLLIVRLAVLMAVTLTVPVVIFPIRSSIIQLLCAAKDFSWWRHILITVSILSFTNVLVIFVPTIRDIFGFIGASAAAMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGIFVMTGSMTLIILDWIHNASVDGH
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
Sequence:
MGHMLFKSLASNQRNHKYMKSGRLHPVCTTELADLAKHQSEFAKRGVKLIGLSANSIESHDGWINDITEIAGCSLTFLVIGDEDRKIAHTYDMLDHQDVTNVGARGIAYTIRSVFIIDPNKVIRLIQAYPASTGRSTTELLRVVDSLLVTDKYSVNTPANWEPGDDVVVPAGLTAEEAQVKYPNMETVKPYLRFIPLARHHLYQH
The following text describes a protein:
Function:
Required for the processing of the 27S pre-rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MYPEALPVGILSNPGTFKRRSGSYSNDKPEVWFAAGSGSPNQKLSSSCVGRACGEMDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKVQTEVLQKRQQEKAHMMNAIKKYQKGFSDKLDFLEGDQKPLAQRKKAGAKGQQMRKGPSAKRRYKNQKFGFGGKKKGSKWNTRESYDDVSSFRAKTAHGRGLKRPGKKGSNKRPGKRTREKMKNRTH
The following text describes a protein:
Function:
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASAADALEPESGSSTAGGGSHPVRAARSARGRRRRSGGTRRAAAPDREYLQRPSYCDAAFALEQIAKGRATGRRAPLWLRAKFQRLLFNLGCYIQKNCGKFLVVGLLYSAFAVGLRAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPQEDGTNVLTTEALRQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITEAGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLQWINFDPLEFLEELKKINYQVESWEEMLNKAEVGHGYMDRPCLNPADPDCPITAPNKNSTKPLDVALVLSGGCYGLSRKYMHWQEELIIGGTVKNSSGKLVSAQALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRMYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVTRVIQIEPQAYAENDNICYSSPPPYSSHSFAHETQITMQSTVQLRTEYDPHTQAYYTTAEPRSEISVQPVTVTQDSLSCQSPESASSTRDLLSQFSDSSVHCLEPPCTKWTLSTFAEKHYAPFLLKPKAKVVVIFLFLGLLGLSLYGTTRVRDGLDLTDIVPRDTREYDFIAAQFKYFSFYNMYIVTQKADYPNVQHLLYELHRSFSNVTYVLLEGDRQLPKMWLHYFRDWLQGLQDAFDSDWETGKITYSNYKNGSDDAVLAYKLLVQTGNRAKPIDISQLTKQRLVDADGIINPNAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRETSDFVEAIEKVRAICNNYTSLGIASYPNGYPFLFWEQYIGLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIVVVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHIALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPACGRNRLPTPSPEPPPSIVRFALPPGHTNNGSDSSDSEYSSQTTVSGISEELHHYEATQSPGIPVHQVVVEATENPVFARSTVVQPESRHQSSPRLQSNPEAGTQQVWHQGRQPKQEVREGLRPPPYRPRRDAFEISTEGHSGPSNKDRLNHKAHSHNMRSPAFGAMGVPGSAYCQPITTVTASASVTVAVHPAVHSHNSCRGSFPSCEEYNEDDRGMFEDPHVPFNVRCERRNSKVEVIELQDVECEERTAGKISE