lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Collagen VI acts as a cell-binding protein.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKILLFKLLMFSWLQISFTQKALPKYADLVFLVDSSSNLGDKGFSQVKTLITRIITSLPIGPDKYRVGLAQFNDDLDIGFLLNTYKGKGPVISHIKNKFAYKGGSLKLGNALTKAHERFFKRVTDRDKSVYPPVLVVVTSGSSLDDVTQPALELQQDGVRIVSVGLKTTPLTQLQAIASSTRHILQVSNIQDIPTISTTLIDSIKDVIQSKTVVPTLSATDISVIPTITEDLNITVDSTIYTCDQEFTADIVFIIDTSHHKPSENEDLKTFLSNVISRLPVSENCAHVHLVKYGSKAELLTTLEIGVNKNSVLEAIRSITAVKEEIANTGHALNFTRTEVVANPKISRKGQGIKQISFLITHRLSADNVTDAAHLLRQDQVTSFALGIAEAKKTQMDQIASHPPDNYVISLKAFSDLSTQVEYIQKNIQNVLEEYTIQSPARTGLIKQGCLDTEVADIYLLVDESGSISTDNFQQMKIFLENLVEMFDIGPEKVLVRCVLYSDSPREIPIGRDFSKDDLKSALQNLRQLGGGTDTGKAINFTQQVITKGENTRPGDVPVHLIVLTDGESQDSVKEAAEIVRGHGVNTYAIGVRGYNKTQLLEITGTEQRIHLANDFDSLQNIKNVIAQQICIEKACESLMADILFLVDSSSGMGLEKFSKVKTFMKDLVNKVEVGLTSVQFAAVQFSNSIKEEFQFNKHATKTGIWDSIDNMKLMGDVAKTGNALTNVADYFAKIKGARPSRKASKNLILITDNPAQDEVKAPADLLRSKGVIIYSIGGFNANKKQLQAISGKLTAYYQSFDKLETVESDLLFRLCNPEVECKRIEVADIVFVIDSSTSIDSTQYKEMQNFMVSLVNKSAVGPDNVQFGALKYSDHNKELFYLNRYKNKLDIINHIYEDTVQHGNTYTAGAIKFSKEFFTEKHGSRKARGVPQIVIVMTDGESHDKAKLNETARQLEQEGIIIYAIGIGKEANTEELVTMAGTEGKWFMVENFSGLQDIRVQVSEAMCNKTDCKVEQADLLFLIDGSSNTSKETFREIKHFVISVMDDFNVGPVNVHIAVSQYSESCIREINFDYSTEKETLKKEIRKIAKTKGHRHIGAALAFTKSTVYRPSSDCRINQGVKQLLVVITAGNASDHVAQPAKALRDRGVDIYAVGIGKVCKTQLAKITGSPEKIYTDDVRSLKSIKKRLVRDTCSKDPVTNCSLDVVVSFDISTKSSGQSVFHDHPELEIILPNILKTMLSMKSPSCGAGKRPQVSVAFYVKDTNSISRFNTYSQDLFNKLKEVKVSGPLYLDSTFLNSAWDIFKNTDKGKATMLLVFTDGLDEDVKQLKITAEAIRSKGLNALVTVALEGSKKVEEMKLIEFGRGFEYNNQMHIGMRGIGVRLARQADHSVEAICCCAFCKCYGERGEPGAFGFRGIKGRNGTKGHQGHRGDDGESGERGLPGLKGEQGIKGCQGARGLKGNRGYEGDKSEDGEPGLDGLPAEQGNTGHPGTKGDKGEHGQTGSPGSRGIKGDKGNQGFRGAPGEPGTSSIIPGPTGLKGDPGQEGEAGRQGPEGPPGSRGTGNLQGRRGVPGPKGIKGKPGENANAGYQGVQGPQGDSGPSGVKGEKGSSGSQGNRGQPGTDGPKGSPGKPGTLGKEGEPGDPGQKGEPTTPGKRGQAGDDGRSGYGKPGKKGLKGQPGFPGESGFMGSNGDSGMDGGKGLKGYKGNPGPSSKGEDGSRGIPGHPGRMGRKGDRGPSPTSACELIEFVRDKCTCCQGKPPCPVYPTELVLALDMSSAVTPAIYTRMLTLTKDIVSNITIRASNCPAGARVAVVSYDSNIKHLIRFSDFHIKEKLIRAVESIPLEKSSQGPDVGGVMKFVARNIFKRSLQGFTVRRITVLLSSGRSENADNINTAVMEYGALGIIPVVIAFNSAPLIKRAFEMDATGAFELIEIKPNVDPLKNFKLCTLCFDRCRPDKSCGDKLIQQKSSVDVAFLLDSSYNVKNDDFEAAREFLSNMIDHFEIEGSTSDRVALVTFNESYHVDFNLLSYDNKIRIKKHIKESVQQVSGQPALGLSLQYTIENIMAKTPNLRKHKVIIIILFGETSQWDKQTLSEASLKAKCEGYALFVLSIGRSHNDTELTELASKPLDHHLLELGRVHKPDLVYANGFLQQFLNYVRTGGAGKYPPAELRKKCSAVAVPVSRRRMPSQTDVEEIGRSEAEYVSDMQLDFISQEQSSNMDNLAFLDLERKLLRADSREAQTDHIR
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKKKEKKEKKAGKRMSKKELAALLIDFFHAKPSETLSMKYIFSELHLTTHPQKMLCADLLHDLSDDDYISEIEKGKFRLNNHGTEMIGTFQRKSNGKNSFIPEGGGDPIFVAERNSAHAMNNDKVKITFYAKRKNKDAEGEVIEILERANDTFVGTLEVAKSYAFLVTENRTLANDIFIPKEKLKGGKTGDKAIVKVTEWPDKAKNPIGQVIDILGVAGDNTTEMHAILAEFGLPYVYPKAVETAADKIPAEITPEEIARREDFRKVTTFTIDPKDAKDFDDALSIRPIKDGLWEVGVHIADVTHYVKEGGIIDKEAEKRATSVYLVDRTIPMLPERLCNFICSLRPNEEKLAFSVIFDITEKGEVRDSRIVHTVINSDRRFTYEEAQQIIETKTGDFKEEVLMLDTIAKALREKRFAAGAINFDRYEVKFEIDEKGKPISVYFKESKDANKLVEEFMLLANRTVAEKVGRVPKNKKPKVLPYRIHDLPDPEKLENLSQFIARFGYKVRTSGTKTDISKSINHLLDDIHGKKEENLIETVSIRAMQKARYSTHNIGHYGLAFDYYTHFTSPIRRFPDMMVHRLVTKYMDGGRSVSESKYEDLCDHSSNMEQIAANAERASIKYKQVEFMSERLGQIYDGVISGVTEWGLYVELNENKCEGMVPIRDLDDDYYEFDEKNYCLRGRRKNKIYSLGDAITIRVARANLEKKQLDFALIEK
The following text describes a protein:
Function:
May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3)P). Plays an important role in protein trafficking.
Subcellular Localization:
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Also localizes to a novel cellular compartment, the 'delta compartment', characterized by colocalization of EPSIN2 and DELTA-ADR.
Domain:
The ENTH domain is required for PtdIns(3)P affinity and EPSIN2 subcellular location.
Sequence:
MKKVFGQTVRDLKREVNKKVLKVPGVEQKVLDATSNEPWGPHGSLLADLAQASRNYHEYQLIMVVIWKRLSDTGKNWRHVYKALTVLEYMVGHGSERVIDEIRERAYQISTLSDFQYIDSGGRDQGSNVRKKSQSLVALVNDKERIAEVRQKAAANRDKYRSSAPGGMYKPSGGYGDKYDYGSRDEERSSYGREREYGYRDDDRNSRDGDRHSRDSEDRYGRDGNRDDDYRGRSRSVDNYGSRGRSSEREREDDGHSSSRGSGARADDNSQDGRGGLQRKFSEQNIGAPPSYEEAVSDSRSPVYSERDGGETPQVTAPGAASPPPPQVAAPEAASPPTGTNTANTTATFVNESPSQKVETFDEFDPRSAFSAGPPAYASTDGVTAPPTVTSMSAPTTSNSVEMDLLGSLADVFSSNALAIVPADSIYVETNGQANAGPAPSFSTSQPSTQSFDDPFGDSPFKAFTSTDTDSTPQQNFGASFQPPPPAFTSEVSHPDTAHNFGFGDSFSAVANPDPASQNVQPPSNSPGFPQEQFATSQSGIDILAGILPPSGPPVQSGPSIPTSQFPPSGNNMYEGFHSQPPVSTAPNLPGQTPFGQAVQPYNMVPHSQNMTGAMPFNSGGFMHQPGSQTPYSTPSGPAGQFMAHQGHGMPPSHGPQRTQSGPVTLQGNNNVMGDMFSQATPNSLTSSSSHPDLTPLTGAIEIVPPPQKKFEPKSSVWADTLSRGLVNFNISGSKTNPLADIGVDFEAINRREKRLEKQTNTPATSTINMGKAMGSGTGLGRSGATAMRPPPNPMTGSGMPMGGGMGVGSYGGMNQNQPMGMGMGAGMNQNQPMGMGMGPGMNMNMNMGGYGQGYPMQPQNPGMVPSPNMPGNNYNPMMGQGGYNPQQSYGGGYR
The following text describes a protein:
Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals.
Subcellular Localization:
Nucleus. Nucleus, PML body.
Sequence:
MEVEEAGAVQTGTGEAVVANERTKQCSAFASITGCDEAVAQCFLAENDWDMERAINSYFEPGVESTLQNKPAADLADPLKQEMHAVTSDACIDLTSDDLVATKSEAVTSNSSTVKQQEDESHFTFLTWNIDGLDESNVAERARAVCSCLALYTPDVVFLQEVIPPYCEYLKKRAVSYKIITGNEDEYFTAMMLKKSRVKLISQEIVPYPSTLMMRNLLVANVNISGNSICLMTSHLESTKDHSKERLKQLDTVLKKMMDAPPSATVIFGGDTNLRDQEVAKIGGLPNTILDVWEFLGKPEHCRYTWDTKLNNNLRACYTSRLRFDRILYRASMEGSQVIPQFLNLVGTEKLDCGRFPSDHWGLLCDFDIIL
The following text describes a protein:
Function:
Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay. Also destabilizes target mRNA by modulating 3'-end processing, creating extended transcripts that are prone for degradation.
Subcellular Localization:
Nucleus. Cytoplasm, P-body.
Sequence:
MWAQLSYTRPESQKTDLTSLFSTDQEQNPLNDYQYQINIRELEEYYNKTILNEDNIQETSSEISSAVSFSPPKNTNAIQPGLLYDPQLMNPFLPSAHLNSTAPTTFKKKLEVQINPDYVPKSSQLPLTSQNLQQLSQQKPKNDASFSSEKESSAQPKVKSQVQETPKQLYKTELCESFTLKGSCPYGSKCQFAHGLGELKVKKSCKNFRTKPCVNWEKLGYCPYGRRCCFKHGDDNDIAVYVKAGTYCNVSSTSKQSDEKRSNGRGSAKKKNLNVKVKALQRMTW
The following text describes a protein:
Function:
Part of the MTV complex that associates with the HipHop-HOAP complex to form the terminin telomere-capping complex involved in telomere maintenance and prevention of telomere fusion. Potentially functions downstream of mei-41/ATR. As part of the MTV complex binds single stranded DNA in a sequence-independent manner, protecting it from degradation.
Miscellaneous:
MISCELLANEOUS: Multiple telomeric fusions result in multicentric linear chromosomes that resemble little trains of chromosomes, hence the name 'modigliani', the name of an Italian train named after the artist.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, telomere. Note=Localizes to euchromatic telomeres of polytene chromosomes. Telomere localization is not dependent on peo/pendolino. localizes to specific interband regions on chromosomes. Localization to telomeres is dependent on ver/verrocchio and telomere associated cav/HOAP.
Sequence:
MSLVPEASTSRAPKYCYFFKTLLVEELELETSYHNLHYGQCALIGRLAFKANQYRLENVRVKCLPKKYSLGEGTVSLLILGLTHDKVVENRVSTGRYCIVRGEVVLHNVQHPKGAKLTAGGVYDKINSLSNDPLAQKQYLSALLATYRPAIDLWYIQVIDRAEDLLTRRLEMRSLIEK
The following text describes a protein:
Function:
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity.
Subcellular Localization:
Preautophagosomal structure.
Sequence:
MAQQRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQAGSVGLVEMLYRSNLLALVGGGSNPKFSEISVLIWDDAREGKDSKDKLVLEFTFTKPALAVRMRHDKIVIVLRNRIYVYSFPDNPSKLFEFDTRDNPKGLCDLCPSLEKQLLAFPGHKCGSLQLVDLSSTKPGTSSAPFTINAHQSDIACISLNQQGTVVASASQKGTLIRLFDTQTKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTKLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGKNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.
Sequence:
MSAVPSFVLPAQWPAPPRIHVLTTLRHGLGVSPAPFDTLNLGNRSSPQGDLLANVERNRALLTQALGLPGAPHWLRQVHGVEVVRVDAPRSADAVHTQPRELDEPVADAAVTSVPGVVLAILTADCLPVVLAAADGSEVAAAHAGWRGLADGMLERSVAAMRSPPQRLVAWLGPAAGPQAYEIGADVFEAFVTRDPQAASAFVATRPGHWRVDLYALARLRLCSAGVPAEAIHGGELCTISDPTRFFSHRRDRRSGRMATLAWIAP
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MAASSVSSGSETERQQQELEDTVLLLFSAFASASSQNTSLLLELWREEHVQYLKRAFRGLGTSYSVLDSSRPWLCYWIMHSLAMLNQPLGPGMDRRTIDFLSRCQDPNGGYGGGPGQIAHLATTYAAVNTLVTIGGEKALASIDRNEVLRFLIRMKQPNGGFSMHDGGEVDVRGCYTAISVAHMLDIMVPEIVDKVADYILSCQTYEGGIGGEPNAEAHGGYTFCGLSALALINKVNTIKLPNLLNWIVFCQGKVEGGFRGRTNKLVDGCYSFWQGGVFSILQHIMPELNRQQLASITPLYEAWNQDVASSSASSSKVTLEGSSEVSPTSRESVEERTAAGIPADAEPRATDGTTTDHQPTGTSPMYTHREDNRRGSISELVTAEQLFPVVDRNIKRAPISVTFEELEDQVSETSKEAKDGAGNTNQAQLSTVDQILNENEQMLYGPLYNAHALQGYILLCCQVLDGGLRDKPGKSPDYYHTCYCLSGLSQAQSSASHRVNAPPPPKAVLGPYTNLLEPVHPLCNVVLSKYTDAIRYFRHHPFRRVP
The following text describes a protein:
Function:
May regulate the dynamics and distribution of mitochondria in neural cells.
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MGRAREMGWMAAGLMIGAGACYCMYKLTMGRDEGNELENEEEDEWDDEQDLDEEEADIWFDFTAMARPWSEDGEWDEPGAPGGTEDRRSGGGKANRAHPTKQRPFPYEHKNIWGVQSFQTFPCALNLTKCAFSQGKKMFTESTIAGFSLTHNVSRHLSSLSVVGSRSPTPQPTVREKALDVPEHPNSSIENQDQIKMYIDEVCRDAVFCCCKSFLQQAGLGLLISMTVINNMLAKSLSDPKFPLLSEGSGCAKVQGLEAQMSLPEKPVLAEEVLAAQMLFSFMCLFTRSGSREMLVEAISP
The following text describes a protein:
Function:
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSNTFSHSLFSQITSPISNHRPKPTSLCSFNPYPLRPISRSPVLSTQSKTSFITNCSSPASDNSSKDETPIELRFPAFPTVIDINQIREILPHRFPFLLVDRVIEYNPGVSAVAIKNVTINDNFFPGHFPERPIMPGVLMVEAMAQVGGLVMLQPEVGGSRDNFFFAGIDKVRFRKPVIAGDTLVMRMTLIKLQKRFGIAKMEGKAYVGGEVVCEGEFLMAMGNSE
The following text describes a protein:
Function:
Prevents the interaction between CTNNB1 and TCF family members, and acts as a negative regulator of the Wnt signaling pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTANEEEFLRTYAGVVNSQLSQLPQHSIDQGESRLGRPATPFLPREAQLWFLGQTGGVGAFPRWEPRTPSGNGGVPPFFKPGGGEK
The following text describes a protein:
Function:
Catalyzes the desaturation of long-chain acyl-CoAs to 2-trans-enoyl-CoAs. Active on substrates longer than C14 and mostly with C18-CoA. Activity on long-chain mono-unsaturated substrates is double than with the corresponding saturated substrates.
Subcellular Localization:
Peroxisome.
Sequence:
MESRREKNPMTEEESDGLIAARRIQRLSLHLSPSLTPSPSLPLVQTETCSARSKKLDVNGEALSLYMRGKHIDIQEKIFDFFNSRPDLQTPIEISKDDHRELCMNQLIGLVREAGVRPFRYVADDPEKYFAIMEAVGSVDMSLGIKMGVQYSLWGGSVINLGTKKHRDKYFDGIDNLDYTGCFAMTELHHGSNVQGLQTTATFDPLKDEFVIDTPNDGAIKWWIGNAAVHGKFATVFARLILPTHDSKGVSDMGVHAFIVPIRDMKTHQTLPGVEIQDCGHKVGLNGVDNGALRFRSVRIPRDNLLNRFGDVSRDGTYTSSLPTINKRFGATLGELVGGRVGLAYASVGVLKISATIAIRYSLLRQQFGPPKQPEVSILDYQSQQHKLMPMLASTYAYHFATVYLVEKYSEMKKTHDEQLVADVHALSAGLKSYVTSYTAKALSVCREACGGHGYAAVNRFGSLRNDHDIFQTFEGDNTVLLQQVAADLLKRYKEKFQGGTLTVTWSYLRESMNTYLSQPNPVTARWEGEDHLRDPKFQLDAFRYRTSRLLQNVAARLQKHSKTLGGFGAWNRCLNHLLTLAESHIETVILAKFIEAVKNCPDPSAKAALKLACDLYALDRIWKDIGTYRNVDYVAPNKAKAIHKLTEYLSFQVRNVAKELVDAFELPDHVTRAPIAMQSDAYSQYTQVVGF
The following text describes a protein:
Function:
Functions as a negative regulator of actin polymerization. Modulates actin/myosin II at cortex actinomyosins to prevent excessive F-actin polymerization around the cell periphery, thereby maintaining proper cell shape during phagocytosis and chemotaxis.
Sequence:
MKIKVTFQERIIEHNFETEITNLQQVTQKLCSLFLITNYYSYSLFLSSGQLVDNINLIDEGSEIIIKHLNRLGTISIGSGYSNSVVGTTNNNAPSSPSSSININGQQIQQQIQQQIQQQQQQQQQQQQQVQLSPDTLINNLLNNLKDNTFKKKAFFDLKDLKEEILIKKFVEKNGIEVIVCQLKELTGNTLSYALSALQTIMSYEFTITSMTSTDTASLITQLLPLTENTSNPSISKTSLSLLCLFLNQSNNLNFKQFSSTLVLEYNEKTKRNYNHTLVQLLSSSNTVDVQLNALTLINIIIGKTMSTTIPGLENGSVTGGENGFNKLLKELDEYEINQKLKKLVESIIVAPELKRQLYIYQRHRFQVITNRKNVTFNKESSEHDALLMKLWSLTYPGVKLESRVSEQWKQMGFQGTDPCTDFRAMGIWGLDNLIYFAQNYNEKFRKIVNSQIDRKEREYPTATAGIVLTFELYNSIFKMGTPNLNPYNSTTSNTTSNTTSTTNIDDLPFFPLFFSHPHAFEEVYCTTFQILDSTWDDMNGTYMHFQKIMSSVKNLIITALESKPTTLEAFDWKCQKNTKNSNGGTNSNQNNSSSNLLLSNFANGSSLLSLLNDLSSSSRDDMKKLLTGVNYQVLDLIKSQKISYFQEGFQFKLHKQLKTKQSLPLNWIFIRLFNNNNNNNNNNENCSYEIQYCFLSTELNQPPLPNQSIPTNYNTIKISDLFFNGESTNSNNKKKDKSLSYFNISIKDEQIQSLIQNQLPLSNLNNSSNSLQLDSSTSMNSIKDSIINISSSNNNIKDNLTNNNTNTNTNNTNNNTSNGNGNSNSVSMSSININNSGQLSPNTTSPILIPQQQQQQPQSSSLSVQHQQSSTPTPSSPVLLSSPSLQSSSSSSSSSSNPNLFTIDLISSNRDDVSNFWDSIKLLSGQEIKSQEGLDDYHSLLSINTSVKLLDLDGIDIPKETPQIPILPDNFDFRTV
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication.
Subcellular Localization:
Nucleus.
Sequence:
MPSKSKGRKSVAGIKPNPSSSLSGAEDEVYFELQRILRNRMCGSELPASLPHLQDQRRHLMDIIERCATQGESNSALVIGPRGSGKSMLLKHVLAELVKNRKVSTNLLQVRLNGLLQTDDRIAIQEITRQLKLENVAEEKVFGSFSENLAFLLESLKKDSSGAQSILFIVDEFDLYAHHKNQTLLYNLFDICQSAQTPITVIGVTCRLDVVELLEKRVKSRFSHRQIHVFNTLTFDQYCEVFRKTLMLPSNFMDKTFAKEWNNHIEMLTEDATITEILQKTYSLDKSVRSLYSLMLLPIARIGADHPTFEGHQLLESRKIHSTDSKAAMLHGVSVLQLCLIIAMRHLTDLYEGDPFNFEMVYNEYQKFIQKKSHTVQQFDKSVVLKAFEHLVALELVKPAEHSTASSTRTQKEYRAMSILVTSSQLAESLSSYPSCPSELLHWAKNPMAS
The following text describes a protein:
Function:
Serine protease (By similarity). Cleaves the proform of PRSS8/prostasin to form the active protein (By similarity). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (By similarity). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted. Cytoplasm. Note=The non-phosphorylated, inactive full length protein localizes intracellularly (By similarity). N-glycosylation and phosphorylation is required for trafficking to the cell surface (By similarity). Interaction with SPINT1/HAI-1 and SPINT2/HAI-2 facilitate its translocation to the cell surface (By similarity). Proteolytic cleavage is required for secretion (By similarity).
Sequence:
MDRGSHRNSSPARTPPQASPARTSPARAPPQASPARTPPQASPARTPPQASPARAPPPQASPARASPARAPPSRSSSGRSSSARSASTTSSPTRVYLVRATPVGAVPIRASPARSAPATRATRESPGLSFPKFSWQETQRQLPLIGCVILLISLVISLILLFYFWRGHTGIKYKEPLESCPIHAVRCDGVVDCKMKSDELGCVRFDWDKSLLKVYSGSSGEWLPVCSSSWNDTDSKRTCQQLGFDSAYRTTEVAHRDITSSFLLSEYNTTIQESLYRSQCSSRRYVSLQCSHCGLRAMTGRIVGGALTSESKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKLLEGWKVYAGTSNLHQLPEAASISQIIINGNYTDEQDDYDIALIRLSKPLTLSAHIHPACLPMHGQTFGLNETCWITGFGKTKETDEKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWIYRKMESEVRFRKS
The following text describes a protein:
Function:
Functions as a Na(+)-independent bidirectional multispecific transporter. Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively. Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides, and nucleotides with cGMP, 2'deoxyguanosine and GMP being the preferred substrates (By similarity). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (By similarity). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood. Involved in renal secretion and possible reabsorption of creatinine (By similarity). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion. Also transports alpha-ketoglutarate and urate. Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified (By similarity).
Miscellaneous:
MISCELLANEOUS: Involved in the uptake of clinically used drugs such as ketoprofen, indomethacin and methotrexate, and contributes to renal and hepatic drug elimination.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Located to the sinusoidal/basolateral membrane of hepatocytes. Apical side of the renal tubule.
Sequence:
MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALPGAPANLSHQDLWLEAHLPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPEGEPLTVPCSQGWEYDRSEFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMSAASINYIMFVVTRTLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWSGGVLLLALVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGSLSQEALNNVVTMERALQRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQTQLLFGAVELPSKIMVYFLVRRLGRRLTEAGMLLGAALTFGTSLLVSLETKSWITALVVVGKAFSEAAFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYGGIALVAACTALLLPETKKAQLPETIQDVERKSTQEEDV
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MILGKAARNFGKHVGFFSGKNQPLFINSSRRFYSNEAPKEEKKVNEEKKVNEEKKAEEKEKKEKTVEDLENEEAEEAKEAEKKKKKRFLPVFHTIGAGIGLTVIVTSVLGYLAYEYKKDITEEERYRLSTLEQHVLKATTGLRDGFENIFANLSDRSEIFESLFGQAKVHKILPPQLPGSKKYTLVIEIDALCELSKASKYPAVYKRAGLDFFLENLKKDFDIYLFFNANIPQNKNEQIYFKIDPNQNYFVGQLYAEHGLKERNQFSKKIEMLDRDPSKVILIDATAPYKHPNVINVGKFHSNSKDTILIELLPVLLNLPKNKVADVRPEIQHLQDLDKAPLSSLLGQYMNEKNINPILKKLKPENN
The following text describes a protein:
Function:
Required for vacuolar protein sorting.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Sequence:
MNSNIEDDPWSSGWNDDNDNNNNNNTSINDPLTGATATTTPYQSSYLTSSQLFTSTGGGGSGSGGGYNSGVNTYNTTIPPNLINVPSSYETIYSHFITKYNNNNNNNNSNSTFTLNDFEINIIDKLISLNYLTNYQKQKILDIIYENNLLPINQSFKFYQILGLLALEIDVPGTGDYVTLQFRLNNNLPDLPEKFINEIINEENEQEEQTSGLLGNRNRSIQSHSHFGPNNQDDWNIDDSTTISGGGGGGGGNFGDPLLVDHSYIHDDLIDESRSVGGTQPQQGGGGGSGGGSGSGSGTIAPNVDSSYIEKYINDIKDQFKPLFSGIDLIKIKEVPEKEGIIFKHINYMITHDLKIGGTSSGTKKVIRRYSDFVWLMEYLLEKYPFRVIPGLPPKKFTGASPDSQFLQRRRRGLHRFLNQLIKHPILSQEPIVQSFLTVPTDLTTWKKQAKIDSSLEFKGQKIQTDFINVIWPIMGEPFLKKWRQAEENIQFIIDKWVKIIILVERYERRQQQISFDNGKFAEMLNGFSKLNTKIYPDNEDNNNSTRNDVNVNVVVVDNNENYKQDFDFNSSGDIININQCLNSIGEFFNKSSQVLIDESYIINTKTLEKFKNYLDYLNSLQELFERTKQLSINQIDLLDKRIKDQEIKFKKISEENPDIKGGELIKLRQSIINDKQEIFQQLNKDWLIKQCCLQEFIIFQETQFLITELWVEWCKDRLKCQEKLVGLYDNLNQEIIHDMPLER
The following text describes a protein:
Function:
Plays a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube. Required for establishing left-right asymmetry of the body plan; controls cell fate and convergent extension (CE) movements during gastrulation, respectively, via the Wnt and the planar cell polarity (PCP) signaling pathways. Required for the proper development of renal glomeruli and tubules.
Miscellaneous:
MISCELLANEOUS: Mutants show development of polycystic kidney disease and left-right (LR) asymmetry defects.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle. Cell projection, cilium. Note=Localized to cytoplasmic puncta in ciliated cells. In the semicircular canal, localized to kinocilia.
Sequence:
MVRISEDLIRRRAEHNNGEIFSLEELSLHQQDIQRIEHIHKWCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEVIENLEGCESLQKLDLTVNFVGRLSSVETLKHNLHLKELYLVGNPCAEYQGYRQYVVATVPQLQSLDGKEISRAERIQALQELDAVRTRVLQQETKYLEEREKQKSNANEHPEINQSLSESQNGTQQYPESSSKTHTEAEDEEREFWEKPCPFTPESRLEAHRHLEEKRRANEKEKEKPKTKTPRTLITPDGRVLNVNEPKLDFSLFEDENNCLLLDLHVYRHMDSSLLDVDVQPMYVRVTVKGKVFQLVLPAEVKPDSSSAQRSQTTGHLLLILPLANEDVKPKKRTIRPTSVTSNQNNKKDTRAAPRRELLEVDPGLAGSLANIVPKGQESSHNPQRCGLEERPVSKDFVDDPEVPPLM
The following text describes a protein:
Function:
RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.
Miscellaneous:
MISCELLANEOUS: Present with 1440 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
Contains two helicase domains. The N-terminal helicase domain has catalytic activity by itself, contrary to the C-terminal helicase domain that may have a regulatory role and enhance the activity of the first helicase domain.
Sequence:
MTEHETKDKAKKIREIYRYDEMSNKVLKVDKRFMNTSQNPQRDAEISQPKSMSGRISAKDMGQGLCNNINKGLKENDVAVEKTGKSASLKKIQQHNTILNSSSDFRLHYYPKDPSNVETYEQILQWVTEVLGNDIPHDLIIGTADIFIRQLKENEENEDGNIEERKEKIQHELGINIDSLKFNELVKLMKNITDYETHPDNSNKQAVAILADDEKSDEEEVTEMSNNANVLGGEINDNEDDDEEYDYNDVEVNSKKKNKRALPNIENDIIKLSDSKTSNIESVPIYSIDEFFLQRKLRSELGYKDTSVIQDLSEKILNDIETLEHNPVALEQKLVDLLKFENISLAEFILKNRSTIFWGIRLAKSTENEIPNLIEKMVAKGLNDLVEQYKFRETTHSKRELDSGDDQPQSSEAKRTKFSNPAIPPVIDLEKIKFDESSKLMTVTKVSLPEGSFKRVKPQYDEIHIPAPSKPVIDYELKEITSLPDWCQEAFPSSETTSLNPIQSKVFHAAFEGDSNMLICAPTGSGKTNIALLTVLKALSHHYNPKTKKLNLSAFKIVYIAPLKALVQEQVREFQRRLAFLGIKVAELTGDSRLSRKQIDETQVLVSTPEKWDITTRNSNNLAIVELVRLLIIDEIHLLHDDRGPVLESIVARTFWASKYGQEYPRIIGLSATLPNYEDVGRFLRVPKEGLFYFDSSFRPCPLSQQFCGIKERNSLKKLKAMNDACYEKVLESINEGNQIIVFVHSRKETSRTATWLKNKFAEENITHKLTKNDAGSKQILKTEAANVLDPSLRKLIESGIGTHHAGLTRSDRSLSEDLFADGLLQVLVCTATLAWGVNLPAHTVIIKGTDVYSPEKGSWEQLSPQDVLQMLGRAGRPRYDTFGEGIIITDQSNVQYYLSVLNQQLPIESQFVSKLVDNLNAEVVAGNIKCRNDAVNWLAYTYLYVRMLASPMLYKVPDISSDGQLKKFRESLVHSALCILKEQELVLYDAENDVIEATDLGNIASSFYINHASMDVYNRELDEHTTQIDLFRIFSMSEEFKYVSVRYEEKRELKQLLEKAPIPIREDIDDPLAKVNVLLQSYFSQLKFEGFALNSDIVFIHQNAGRLLRAMFEICLKRGWGHPTRMLLNLCKSATTKMWPTNCPLRQFKTCPVEVIKRLEASTVPWGDYLQLETPAEVGRAIRSEKYGKQVYDLLKRFPKMSVTCNAQPITRSVMRFNIEIIADWIWDMNVHGSLEPFLLMLEDTDGDSILYYDVLFITPDIVGHEFTLSFTYELKQHNQNNLPPNFFLTLISENWWHSEFEIPVSFNGFKLPKKFPPPTPLLENISISTSELGNDDFSEVFEFKTFNKIQSQVFESLYNSNDSVFVGSGKGTGKTAMAELALLNHWRQNKGRAVYINPSGEKIDFLLSDWNKRFSHLAGGKIINKLGNDPSLNLKLLAKSHVLLATPVQFELLSRRWRQRKNIQSLELMIYDDAHEISQGVYGAVYETLISRMIFIATQLEKKIRFVCLSNCLANARDFGEWAGMTKSNIYNFSPSERIEPLEINIQSFKDVEHISFNFSMLQMAFEASAAAAGNRNSSSVFLPSRKDCMEVASAFMKFSKAIEWDMLNVEEEQIVPYIEKLTDGHLRAPLKHGVGILYKGMASNDERIVKRLYEYGAVSVLLISKDCSAFACKTDEVIILGTNLYDGAEHKYMPYTINELLEMVGLASGNDSMAGKVLILTSHNMKAYYKKFLIEPLPTESYLQYIIHDTLNNEIANSIIQSKQDCVDWFTYSYFYRRIHVNPSYYGVRDTSPHGISVFLSNLVETCLNDLVESSFIEIDDTEAEVTAEVNGGDDEATEIISTLSNGLIASHYGVSFFTIQSFVSSLSNTSTLKNMLYVLSTAVEFESVPLRKGDRALLVKLSKRLPLRFPEHTSSGSVSFKVFLLLQAYFSRLELPVDFQNDLKDILEKVVPLINVVVDILSANGYLNATTAMDLAQMLIQGVWDVDNPLRQIPHFNNKILEKCKEINVETVYDIMALEDEERDEILTLTDSQLAQVAAFVNNYPNVELTYSLNNSDSLISGVKQKITIQLTRDVEPENLQVTSEKYPFDKLESWWLVLGEVSKKELYAIKKVTLNKETQQYELEFDTPTSGKHNLTIWCVCDSYLDADKELSFEINVK