The following text describes a protein:
Function:
Acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
Sequence:
MTKFSEGHYDILNLIEVKSNIQEKNILGYSIDYTVGGLFLFGGFKIDIEENNGIICNDAYLIHIKNDKAEYETLSIKIKPSIRCYHNSCTLLENYVIIFGGLNSEVPFVALNDLWVFNSLNKTFVEIKLKCKEKNKEKNLQNGINGTNEKGYISQTDDENCSDNKYGENQDYGSNDSDSKDGEDIDKDDSILDNSYVKNLRKYLKSNKSDELHSSDIPCPRYFSSLDLYIIRKNNIEEEKGFKKDEIKIIKNNIIVSNSLNYEYFSLILFGGYGGYDRSSYNDLYEFNILNNEWILRGCKGNVPSTRYGHISFIHGNNLFILGGTNAEISFNDMYSCDLKNNEWSEVDFSYSFNISKVFCRSVLVESIDRNIIFIFGGYNIISDEKGNRKIEYNNIELNMLKLYDTFKLEELKYNIIQNNEENIIKNNNMEEINNMNSNNVKNEIISTKHDIYEDSNISNNITFCSITYDFMDSNLIITDNKKKIYIMNISNIIGPKYAIFNIWPKQCDINGNKKLLFRGKGFTNEGKILVKYKSDDINLYSEGIYINENNIYTIVPNAKNKIKNNICQVQLSINDKCYTTNSCFLEYYYNIDPKNTLIFGSGLLEPVCLQKDNIFFLIAKNSLNEHKKIGGDKFQISIIYEQKSEQYDIKYFVYDLNNGFYIVKYFSFLNDKQMKVKMQNVGKNNNIEQRNNNNDNNDNNNNDNNNNNNNDNNNNNNNNNNNNNNNNDNLNEQLNCNVVQRKNQNDLETLEGPQNISNKNSMNNEDIKSNTNNHMEILDLNGTLKITVKLKDENIQNSPFFLKVDNNLKDKIIYVKQFINDRLENLLRKGECLFDLIKNKNMNTNNLIQLNINIDHFLNTFPKAIHDINIIEQYILYGLIDIDKIKNVITNLHEEDNLVNASQEEEIYIDKEIHELINNEKFKNDQTDEMGEYTATTTNNVKHTNNTNNNDTHITDTLTHINENNDTRNNFLKVKDNHKIVDFINENKLKFLDYIDPNIMKKLRNYINLLNTEELNLKNKKDNKKIDDSNKKDLLGIKKKRSEDKFHLDNNLEKDEKKIEVIKNLLIFYHKLKTVCLSKKEKELKDEFIKEEKESIKKLKLNYNKFVNIKKNLEVSNVYLHNNGYDSSLKELETTKKYLIEIKDEVTKIKQISDNIIKIDNVEELNKDIENLNNEIHEIEKMWLFIKKKEEILNEFFFCPFKDLDVEDFDIQIKKLQNDFKKIKVDRKHNICKEETLKLKEIIKFISVLCEIKKPFIKDRHIKEMENNINEEKEKNKEEDKINIIIDDSTLTIYFYKLNIMKYHDTIEEVIIKAYNEKIIEETINKFEDYWDKIYFKKKEYKNNILLTYIDDICIDTIEEHQVTLQNCFSSKYFLFFSDELNLWQKKISNIYEVIQLLKDIEKLWIYLQNMYIYSEEVKKELPLYSKFFLTINDEYLEMLKQIIDNNIKVVDFSNEGGIIEKLEELKVKLCKSEKPLNEYLDSKRKSFPRFFFISSTDLIDILSNGNNFKLVNTHVQKIFLSIRKFVTKNEQLTDNEIQNEVKLNNQETITEEKNKNANENSNEIETNKYNKKEELTNNRDGDGDDDDNIKNDKDEKDEKEETIIKLISSYGEEICNFHEGLVLKGKVECYLNDIIDHIKYTLKYYITNLFRLKDLFNNEKEKWIDENYLAQVFILCNTIFFVNDVENILIKKDINIYEELNKYYKNHILQLENVIKKVQKKLTIKNRIKIMCIITLDTFYRDVLEVILKNKSSISINMFDWQSQIRMYPFFKNQKIYEQNENQTEESNLKLDNKNLDNEHQEGKQEYNNKNNDNDNNNNNNNNNILNNELSKYTCLTHFKDLYIKIKIMDCSFNYSYDYIGNYQRLVITPLTSRIYITATQALSLYMGCAPAGPAGTGKTETTKDLSSFFGKNCYVFNCSDQLDYKSMGNIFKGIGSTGCWCCFDEFNRLIPEVLSVCSIQFKSILDCKRNNNNVCIIGSDEIIVKKNCAVFITMNPDYLGRSKLPESLKILFRPITVIIPDFNKICENMLMAEGYVNAKYLSIKFTTFFELAKSLLKDKHCDWGLRSIKSVLTKAGDLKRNYPDVDENKLLYSAIHDINIAKISSSNCPIFSGLLNDIFFSNQNDITDINDINDINENKKEKDNIEELKSDNVKEEKKTKKKHLEDNNNNKKKELFNLNNIEKELMDICKKNHLFGLNYFVKKIIQLNDIMNIRHCVFIMGEAGCGKTTLFNMLMEYQKKQNLKTVSIRINPKSINIDDLYGNVHIKTREWKDGVFSKYMRNYSKKDDCDKAYIIFDGNLDSHWIENMNSVMDDNKVLTLSSNERILLKNHMNLVFEFSDLMFATPATISRAGLVYFSVDPNDLWKNYFLSWIDKHDNFNSNIKKLFEKLMYKYVEPTFSYLSTLQTSIKISPMSHIQSLSALLDILLIDNNYESVEHYFIYSVIWCFGGFLGEKDNVNYKKSFDKYWKNTFKSIKVNRKISVFDFYVENNKFKEWDEAEITNELKQNYVLQDDIFIETIESYSYKYICKLFLKSDMPILFIGKTGVGKTQLCKKILNEEKEEFKSFYMIFNYYTTSKNVQTLMQSCLEKKSGKQFSPPYQQKLIYFIDDINMPKCDDYNTQSAIELLCQYIDTNSWFDLEKLNLIKILNTKLISCMNYNRGNFTINPRLIRHFFILNINFPENNTVNSIFSVLLKNHFNNFKQDVSDLIPSILKSTISLFYNIEKTFKRTATYFYYEFNLRDIHSIVKGLLTTTPVTFQDCDKLLFLWLHECERVYSDKLNKKDKNKYKKIITDIIKKMYNKYEINKFVMKYDSTLLFSNFHKGSHDKTYDICKNMEELTLFLNEELNEYNNSYNVNIVLFSDAIKHICKLIRIVDNLKAHALLLGIGGCGKTTISKFSSYISSKTFFEMDFSAHCTDNDIKKYLQNIFHKCAMKNEDIVLFLKESKIHDTFFIYVNEYMCSNNIIDLYTKEERDYIIHNIRNIAKADGIEQSDNNIFDYYIKKVNDNLHFILCFSPTSNNFRDKSNNFQCILNNTMIDIYDNWEADSLMCVGKNYVSNIYMNINTGDILLDQEYINLKNKNIEKDITLGNKQIEKNYIPTISTNDGDDHYKDMDKTNMKNGDITTTINNIPIDNNNNNNNNRDNIDGNNFFKNREGNDENMKRKVYSNNFTNQNDLNTNITNNNNNNSNNNNNNIYDKNDSILKEEEYVNLKDIITEYLKECYEDLLDISSFYYSHERSHIYITPKLYLESIKTYHIMLLKNITNINNKMNMLKNGITKMNETSSNVENIKNCLKDKKKISEEKMEAAEKYAIDIGNEKMVVKKESDLADIEEQNCLEIQKKVLKQQEECENDIRLGIPLIEQAEEALNTLNKKNIQELKTLNKPPPGVEDITAAVMQLLATIDTTISIDKFGKIKDRSWKSAQKMMINPEKFISLLKDYKNKIDENLVPDCNFKYVENLINLPHFNKNAIQKKSKAAAGLAEWVLNITSFYKIIQNILPKRILLDNTKKGLEEANEKLQIVREKVQSLKAKLSELISQYDHAIYERDLVILEEKKLKTKLELSIRLIDALSSEEISWSKQYESLKKKKKTILTDILLSSTFVTFCGGFTKKYRNKIMTNCVDTLKRKNEIQNNIFNNMLKKINNNDQNFINNNNNNNSSNNNSTNFGYNEDPQKKDNHNNFDISNKLNIKNEKKDNELGNDNLKKEEMIYDIFLVNNFNLDLLINEEVLSKLSKQGLTLNSVCIENNIILENSDKFPIIIDPQMESLKWLINSHKEKSEKLIITDINDKILLKKIEECISFGYSIIVENADEYIDNTLYNVISKNIIKRKNNYYININDKELMFHPSFYIILHTQLSNPHYQPEIQSACSLINFTVTPDDLEEHLLSITLENEFNHLSKKKKKLSLLKYDYMCQLSFLQSSILQKLTDAKGDILEDVSLIENLEKTKLLSENIAKKTEIVKNTEVHINTIINLYRPLSKRGVMYFFILQKLKNLHSFYFYSLEIFLKIFIKCLNDSSPNRSPSKVNQEQEYYLKSEDNDFNDDYLGSTKEEEKMEDEEKMEEEKVDEEKMEEEKVDEEKMEDEKVEEKMEEEKVVEENTEDEKAIEINTEDEKAVEKNTEDEKAVEKNTEDEKAIEKNTEDEKAVEKNTEDEKAVEKNTEDEKAIEKNTEDEKAVEKNTEDEKAVEQNTEDEKVVEENTEDEKAVEKNTEDEKAVEKNTEDEKVVEEKIEDEKGEEQKAEEENVGIEEVEKVQIDDYKVSEKKGENKNCTYEENGKIDKDKEDDLEEEEDFENDDFTNEETKIDKNEVEKRVNMLTDLLNIKMWMYMDKGLLERDKLIVKCLIMLHLEKLNDKISEEEEEIFINPKYKLSNNNITSIRNKKENESMEKKLMNKSFINEELYEDCKNLENLKDFENITESFESESMSWKQWFLSEKVENEELPRKYNNIKDFSKLLLIRVLRKDRFLIALKNYITKNIKMTNDEKNNTYALENILDEYIDNKTPVLFLLTTGYDPSKEIEDYINKMKNNAIKKNDSNKKESNKNNIAYVNISMGQGQENIALKYLKEISKCGGYIFLQNIHLMTKWLKEFEEILDKIFLDAHVNFRLFLSAAIPNEKDTKLLPEKLLKKCFRINNEKSYSLKDNIKCCLDKFENGQYDDKLKTVILGLSYYHSLLLGRFLYGKIGFSQSYSFNDNDLEISFNIIKRYLKTYESFPLADVLFLIGEIIYGGHITDIWDRRINKTYVKNILKEIYRNIISINEKNKNINMDFHHPNDSNNNYNDDDNNNSHKNNKNNNNNNNKDDDDESNNSNDNEEENEEKLILKNTKHNILFDVFKFPDCSKYNINQLKKYIDEKLNKEQTYLLGLHINAEIEYMKNECSRILQTLQELSNKEIASTESYKKNTKIIKKEKPGDNKDNKYTHDQKKETIHKEEDDEDEKHSGSNKSTKIIYDIINHLLNELPDKIDTNDLKIEDSQTNTFMVIALKEAEKFNKLIECINDTLIEIKLVLDGILNMNDKIQNTIKSLMLHNIPHIWINYSYPSKKKLMPWFENFKLRIIFIKEWISKIRNNIFLPNSVWLSALFNPISFLTAIKQKFAQENKVPIDKLKLKWQVTNITKLEDLNNKNNALYIHGLYLQGASWFINSKNDTFTFDKDNINDNVSYGNIIESVPKHIYYSMPLIYVYCISNEQDELLKENMEYRSLDTPLYVTSDRGNTFVCSIDLNLEMEDIEDKWILAGVALFLSDD