lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MFIYYPTSGETVTRAELVHNIPTQNDNFLIRGIELSRPRNGKLQISIFPSSFLLRIKFIKTVVHTASCPPLLLSFQTDNSESEMQQSQMEGQIQCSSSPATTTTTGTSHPSNIQYPTLGQAAYPFPDPYYRGTNIFNPYETQSYPAQPYPGQPMVHLQFMGIQQAGVPLPSDTVEEPVFVNAKQYHGILRRRQCRAKAESEHKANKSRKPYLHESRHLHALRRSRGCGGRFEKKDKQQKEKGSNDNNPQSQSQMNINLNSDKT
The following text describes a protein:
Function:
Involved in metal tolerance. Probably involved in the transport of metal-bound phytochelatins. Compartmentalizes cadmium within vacuoles, thereby protecting cells from cadmium toxicity.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MVLRYNSPRLNILELVLLYVGFFSIGSLNLLQKRKATSDPYRRKNRFGKEPIGIISWWILGIALTYVVDISNLVIYALRVPNWWPCKTTVVCLILFLLFWIIVLISCADSKALPKNADSILKAYRLSVLYVWAIDIVFETIFIVYSPHPNETFQGIVLADHVARLVLCVFATAIYLTYRRKRHTHDPLDFEERQLTEESNVNENAISQNPSTVQLGVSASTSNFGTLKSTSKKPSDKSWAEYFRSFSTLLPYLWPTKDYRLQFQIFICIVLLFLGRAVNILAPRQLGVLTEKLTKHSEKIPWSDVILFVIYRFLQGNMGVIGSLRSFLWVPVSQYAYRAISTKALRHVLNLSYDFHLNKRAGEVLTALTKGSSLNTFAEQVVFQIGPVLLDLGVAMVYFFIKFDIYFTLIVLIMTLCYCYVTVKITSWRTEARRKMVNSWRESYAVQNDAIMNFETVKNFDADDFENERYGHAVDIYLKQERKVLFSLNFLNIVQGGIFTFSLAIACLLSAYRVTFGFNTVGDFVILLTYMIQLQQPLNFFGTLYRSLQNSIIDTERLLEIFEEKPTVVEKPNAPDLKVTQGKVIFSHVSFAYDPRKPVLSDINFVAQPGKVIALVGESGGGKSTIMRILLRFFDVNSGSITIDDQDIRNVTLSSLRSSIGVVPQDSTLFNDTILYNIKYAKPSATNEEIYAAAKAAQIHDRILQFPDGYNSRVGERGLKLSGGEKQRVAVARAILKDPSIILLDEATSALDTNTERQIQAALNRLASGRTAIVIAHRLSTITNADLILCISNGRIVETGTHEELIKRDGGAYKKMWFQQAMGKTSAETH
The following text describes a protein:
Function:
Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
Sequence:
MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDPEKAPITHGNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGEFGIQEHCENKPVIIGWNRNRAALSQKPLNNNNEDDEGISHVPKPYGNNDTAKKMSNNNNGLTEVLKEIAGLDTAPQIRGNETNSRETFLGRINDCYKRSLERKLPPSCMIGGIKDTQGKRVILSGSTEVISNEGGRFCYPEFSSGEESEEDALFSNMEEEHESWDESDEELLAMEIRMRGQPRFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSVVSYGQGSIQSMVSSDSTSPDSSLTEESRSETASSLSQKICNGGISPGNPGDSKDMKEIEPNYESPSSNNQDKDSSQASKSSIKVPETHKAVLALRLEEKDGKIAVQTEKEESKASTDVAGQAVTINLVPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAMATEHLEGPVNSPKTKSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTSPRQKIPKVELITSGTGPNVPPRKNCHKSAPTSPTATNVSSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPTYARSSKNAIKVPIVINPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESEVPDNTTSKTTDCLQTKGFSNSTERKRGSVAQKVQEFNNCLNRGQSSPQRSYSSSHSSPAKIQRTTQEPVAKTEGTQESQMVGSSSTREKASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTPKSTPVRPKSLFTSQPSGEAEAPQTTDSLTTKVQKDPSIKPVTPSPSKLVTSPQSEPPPPFPPPRSTSSPYHASNLLQRHFTNWTKPTSPTRSTEAESVLHSEGSRRAADAKPKRWISFKSFFRRRKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFMYRCDPAQGQLSVDQSKAGADQAAVMEKGRAENALLQDSEKKKRGHSSPSQIPKKILSHMTHKVTEDFSPRDPRTVVGKQDGGGCTSVTTALSLPELEREDGKEDISDPMDPNPCSATYSNLGQSRAAMIPPKQPRQPKGAVDDAIAFGGKTDQEAPNASQPTPPPLPKKMIIRANTEPISKDLQKSMESSLCVMANPTYDIDPNWDASSAGSSISYELKGLDIESYDSLERPLHKERPVPSAANSISSLTTLSIKDRFSNSMESLSSRRGPSCRQGRGIQKPQRQALYRGLENREEVVGKIRSLHTDALKKLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYYTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPDDPEKEEDDMEETEEEAKGETDGKNPKPCSEAASSQKDSQGVMSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPSPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPLRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQTFTACPSLVQRNTLLQNWLDIKRTLLMIKFAEKSLDREGGISLEDWLCAQYLAFATTDSLSCIVKILQHR
The following text describes a protein:
Function:
May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MESCNCIEPQWPHDDLLMKYQYISDFFIALAYFSIPLELIYFVKKSAVFPYRWVLVQFGAFIVLCGATHLINLWTFRIHTKTVEVVMTTAKVLTAAVSCATALMLVHIIPDLLSVKTRELFLKKKAADLDREMGLIRTQEETGRHVRMLTHEIRSTLDRHTILKTTLVELGRTLALEECALWMPTRTGLELQLAYTLRQQNPVGFTVPIQHPVINQVFSSNHAVQISPNCPVARIRPISTKYMPGEVVAVRVPLLHLSNFQINDWPELSTKRYALMVLMLPSDSARQWHVHELELVEVVADQVAVALSHAAILEESMRAQQQLLEQNVALDLARREAETAIRARNDFLAVMNHEMRTPMHAIIALSSLLQETELIPEQRLMVEAILKSSNLLATLINDVLDLSRLEDGSLKLDNGVFNLHTMFREVLNLIKPIASIKKLLITTNLATDVPEFAVGDEKRLMQVLLNVIGNAVKFTKEGSVSVTALVAKAESLRDARTPDFIPLATDDHFYLRVQVKDSGPGINPQDIPKLFTKFAQPQTPANRNSGGSGLGLAICKRFVNLMEGNIWIESEGLGKGCTAIFVVKLGSPERSNGAMVPFASKPLVNHIQSSFGGLKVLIMDENGVSRTVTKGLLMHVGCDVLTVASSEECLLAVSREYRVVFLDLSMPGFDGFEVAVQIRKRFSKRHERPLIVALTGSADRLTRENCVRVGMDGCVLKPISVDKMRSVLSELLERRTVFEPL
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MLSPWNDCVGDDHQWILKPLQNRLRYERPLPVQQAVVPTVRRALLSGLPMDVCLTAPTGSGKTLCYLLPLLQMITEAKKGTNHTRLLALVLVPTKALGQQVTHELQRLTRGTTITTVSLCDEMSVKEEAAALVRTVRLVGSGTHQTQGHYRNVPYMNIYNGDSVSLPSNAAGVAHNEDESEDGASSSDGGNGEEVGYDSMVDSSLHYYSRADIVISTPQRLLRHLDGTPGFTLLHLRLLVIDEADQVLSGNFANFVAKVVERFEEEQASRVGSTGDRRRLTQLTYSLHKFLCSATLSSHITRISEVRLRNCRHFTLDSFGTEIQREDEGEPLPLPSTDDTGSRKKNKRDQERGNANTKNKRGDDVGKGGEEDSCEDGNEEVKLPLSRQQLVRTSFALPPRLQEHVVFVEDWYRHAVLLKLVRAIVDKQKKAEALVKEHKRREEGLAAQDDESEGTGLGSNGYGTFSRENVRECESTEFRALPHRRRGASKLVGASDPSYPSCDDDAGRRIVIFCRSADEARVMGHFLLSAGVQATEFTTLATESERRRALLKSRPDSCVVASDALMRGVDVPNVGHVIMYNPPETLSQYVHRAGRTARAMRAGHLHLLLQKLGPSGTMKDGEVAMFKAISAAVSRMQPVRYERHFFMFDVAPTQLGKVAIESSPEGGNNGEGRGLVKDKARLLIEEADRYLKETQLRLTGRWVSALESARRGDAVGNKPSSATFGGSRRFISQTKRERG
The following text describes a protein:
Function:
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.
Subcellular Localization:
Cytoplasm.
Sequence:
MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC
The following text describes a protein:
Function:
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGPRPPGESPAIKEDSTGLGPTHEPFSGQPNSTSGDVLLSRRGPGHAIRPPGRAMVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGARGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEESEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSIHSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELQVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKVLALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFISTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVIKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP
The following text describes a protein:
Function:
Amplification-dependent oncogene.
Miscellaneous:
MISCELLANEOUS: 17q23 region is one of the most commonly amplified regions in breast cancer and therefore may harbor genes important for breast cancer development and progression.
Sequence:
MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDDSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ
The following text describes a protein:
Function:
Involved in protein export.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSWFRENWRIAALVVLVVASSVALFAPGIGASANTSGQQAATGDPTNLNYGLELSGGVRLRTTVTGVTADGVSVTPDNEGEIATRISTALDVDRGDVRARPATGSVEVYQNVSTSSLRTTLEDAGYSPDSVRRGVTQATRDNIVSIIGSKIDATGLGGAEVKDIETSAGAQAHYIVVEVPGQNASQVQSLIQGRGQVTLDAYYPGSNGTNVNATVLRGDELVEVDQPKRDQNGRPFVPVQLSAEAAQRFTGDMTQYGFTSQAGISNCRFPNGGYCLLTKLDGEEVYNASMGPTLARTLSSGKFVNNPSFRITANSMTAARNLQVNLQAGALPAEITVQNSYYVAPSFAQKYKPLSLVTGLAAAIAVAIMVLLRYGEPKIAIPMVFTALAEVVILLGFAAVSGLALDLSHLAGFIAVIGTGVDDLVIIADEVMTEQVSSSRIFQSRFRKALWVIGAAAATTILAMSPLAVLSLGDLRGFALVTILGVLIGVLVTRPAYGDVLRRLLTTDT
The following text describes a protein:
Function:
Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme; Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol.
Sequence:
MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRETLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVSAIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGKNCELLLVVPEEVEARQSWRADV
The following text describes a protein:
Function:
Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MARPLRAARLPPPLLLLLAAGASLGAYAVGVDEPGPEGLTSTSLLDLLLPTDFEPLDSEEPSEAMGLDAGLAPGSGFPSEDSEESRLLQPPQYFWEEEELNGSSLDLGPTADYVFPDLTEKVASMEDPGQAPDLPNLPSILPKMDLAEPPWHMPLQEEEEEEEEEEEEREEEEREKEAEEEEEEEELLPVSGSPGATAQAHAPSPSTSSSTSSQSPGATRHRQEDSGDQATSGMEVESSVKPTLSVPSVTPSTVAPGVQNYSQESGGTEWPTGGLGVQSEVPQGAGEGATVGAADFDGQQGALPSSSLPQTVPPSGTEVPSEGPLYPRIPDSLPPGPQDTESTPSSATWGQEGLSEQPLEGQAAEAHSLTPWDSTQVICKDWSNLAGKSYIILNMTQNIDCEVFRRHRGLRLLALVEEVLPRHRSGHRGDWHISLSKPSEKEQHLLMTLVGEQGVVPTQDVLSMLSGIRRSLEEIGIQNYSTTSSCQARATQVRSDYGTLFVVLVIIGVICFIIIVLGLLYNCWQRRMPKLKHVSHGEELRFVENGCHDNPTLDVASDSQSEMQEKQPSLNGGAINGPSSWSALMGSKRDPEDSDVFEEDTHL
The following text describes a protein:
Function:
Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Aids the autocatalytic processing of PRB1. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.
Miscellaneous:
MISCELLANEOUS: Present with 4930 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MVTRHRVTVLYNAPEDIGNHMRQNDTHLTVRGGSGVVLQQRWLLERTGSLDKSFTRITWRPRADLARSLSVIENELSAGFSVYSNSSDVPERFITNPVYNSFHSEKFDIEQYLPPEVDLNLSWNPEDFTYDISVEPTQIQIVEYRLLKQGEEFTIARVKDEKLEVGVFFVDASDESDVDIGGIRCNWRMDDGKMERCQKTSLLYKQGHIAYNHSTTTTSLYLNEPIGLHPKIMIDLTDFEERPKCMYLMHLQLPLELFIDKFQSSPLLLFGEDDLELPEYSLRDKAWGSESIFELKAGTMNEVTLHTRYIEPSNNKGDKLEVSFDPEVILACDTGDNKVSRNPFYKKGLGYESLFTDDTTFRHLNSTTLLVPIPRPDTKDYSKIKNGTLLCLLISIIYIFSKVFGNNKKKRSVKRE
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEKPTGVIVFLFMFILFAAAQRNGSNIMENPFHVGVILDLTTLVGKMGQTSISMAIDDFYSINSNYTTRLVLHTKDSGNDVVQAASAALDLIEKIEVQVIIGPQKSSQAALVSYVGNKSHVPIISFTATSPSLSSALTPYFVRAAFDDAVQVDSISSIIRAYGWREVVPVYEDSDYGRGIVPYLIDSLEQVDCRVPYRSVISLVATDDQIIEELYKLMTMQTRVFIVHMSVPMGSRLFRKVNEAGLMSQGYAWIMTDGLTSLVESLDPSIIASMQGTIGVRLYVPKSRKLDHFARRWRRRFQQENPDDQPAEPGIFALWAYDTVWTVAMAAENVKGINSSFLKLANTGNSTGSDRLGVSIAGPLLLKLISESRFRGISGEFLFADGQLQSSTFQIINVVGKGGREIGFWTPQHGIIKQLKKNRTKEYSALMTDMNPVIWPGESTVVPKGWEMPLSGKKLRIGVPLLDETDEFVKVERNPITNAITVSGFCIDVFEAALQTLPYALPHEYIPFENEKGLCAGTYDDLVDQVYFQFTISSIISSSPSIRFILIDLCQQKYDSVVGDVTIRENRSRYVDFTLPYTESGIAMLVPVKDSINKNAWIFLKPLTFDLWLGSLAAFFYTGFVVWVLEHRINMEFRGPVSQQLGTIFYFSFSTLVFAHREKLENLLSRIVVIIWVFVVLILTSSHTASLTSMLTVQQLQPTVTDLHELQNNGEYVGYPVNSFVKGLLMQLNFDEKRMRGYSYSDEYVEALKKGSHSGGVAAIVHEIPYIKQFLSKYCKGYTMVGPIYKTAGFGFVFPKGSPVVPDISRGILNVTEGDSMKQIEKKWFGGRDSCLKQGDIVGSGSLGFNSFWGLFLLSGAVSTCALVIFLASFVCKNWHEMRDIDRDKSISQRLISWVRYYNKKDYSANTFRKDNSEDSEQDADGTRRNSGEIPATLDDDPSNGRRSISNLSDVSCPPGESSSAELASPCSEARPISIIVTNRRH
The following text describes a protein:
Function:
Required for DNA synthesis. Required for entry into or completion of S phase. Involved in DNA replication and seems to participate in the activation of the pre-replication complex (pre-RC) and in transcription elongation. May play a role as key coordinator in assembling the replication fork. Proposed to function at replication origins following the binding of the mcm2-7 complex prior to the recruitment of sna41. Probably is required to stimulate phosphorylation of the mcm2-7 complex by the dfp1-hsk1 kinase complex. May recruit the DNA polymerase alpha:primase complex to replication origins and is required to maintain it on chromatin independently of sna41. May have primase activity. Binds to single-stranded DNA.
Subcellular Localization:
Nucleus. Note=Associates with chromatin.
Domain:
The zinc finger-like domain binds a zinc ion and is involved in self-association.
Sequence:
MHDPFIAEENDLDLEEKRLQRQLNEIQEKKRLRSAQKEASSENAEVIQVPRSPPQQVRVLTVSSPSKLKSPKRLILGIDKGKTGKDVSLGKGPRGPLPKPFHERLAEARNQERKRSDKLKTMKKNRKQSFQRKRNILEDGKSEEEKFPMKCDEIDPYSRQAIVIRYISDEVAKENIGGNQVYLIHQLLKLVRAPKFEAPEVDNYVVMGIVASNSGTRETVNGNKYCMLTLTDLKWQLECFLFGKAFERYWKIQSGTVIALLNPEVLKPKNPDIGRFSLKLDSEYDVLLEIGRSKHLGYCSSRRKSGELCKHWLDKRAGDVCEYHVDLAVQRSMSTRTEFASSMATMHEPRARREKRFRGQGFQGYFAGEKYSAIPNAVAGLYDAEDAVQTERERKERYKKQRAQAEREREILVRLSKRCCASSSSSSNSNNLSTGMSMRTLGHQYLNLQGSGVKNLHDKGNPTALSKDSEIDSSTKKPSVLASFNASIMNPKSSLPSFSNSAILGTNDAASGTPVPQDTTSTKVSPAVVFTSSPRIFSPQSLRKIGFDPTHSADASTTHSTATGLSRSGSLKNIKFRYEFTESDDEDDLEIVP
The following text describes a protein:
Function:
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MAYHTPFAAQPPVASSGLPLTLISLDDWALVTLTGADRVKYLQGQVTADIDALSADQHVLCAHCDAKGKMWSNLRLFYRGEGLAFIERRSLLDNQLSELKKYAVFSKVVIEPQPDAVLIGVAGSQAKTALAEIFTELPSAEHPVTQMGNSTLLHFSLPAERFLLVTDTEQAQQLVEKLAGRAQFNDSKQWLALDIEAGFPIIDAANSAQFIPQATNIQALNGISFTKGCYTGQEMVARAKYRGANKRALYWLAGNASRVPAAGEDLEWQLGENWRRTGTVLSAIQLNDGTVWVQAVLNNDLAADSVLRVRDDALGTLAIQPLPYSLAEDK
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MELTPEEIRARRLRKLGAKTTKNVANSNAPSTEDGNSTSQATTSNSGSSSTTTTTTSVELEKVADSQQMPTTVAPIGPGKADTVPMESSNSDTVGSSSSLTGSNTTDPKTDLILPDKIEASLMLGLEVAEQSQQQPQQQQQKARSVLVASVSASTASAALRKKPIPSAVVAPSMTAPVNTWAVKKRSSSDHCATKPDGADHHRTDSTEGNTLDPKTHCEQDSRVSAQDELLQIMLRIMKINSKARYSNSRFTIEANVLENALEMLDRQRYDEFCAEVIVEVVKGIYYGKLIESHGEDSDAGRLSDSWSTIPSKKVKPIMLDEVVIGRSGRSGSSGMAAGSTATPMDIDIEMQPEEDAPGYCSSKPSMKAFANNRVAALEYLIGCYLRSNEELYSYTKVKKSKKMYLAETLPSVVSVIRQQTLKYAILVLKNTFQSFCQPDGGSVESGGSSGGAINSSSTGGSTSSSTSKTTTGSTALEKSPLLTLMYENKVSADFMSNLMAESRKSDGEEDFRIIFNAVLDDLFIDMQNAICNENIVADPLNRLKELIETRVDNTHPICLLIVEHRIFLTAFTPDKYFAREISKVSFLAPFLSLSVMLDENPKFASHHFSDNVCDRTLASSFHAILSNTRKVLHSIFLVLLSNQYSRYEMLNYIAAILKSNAKRIQYNADDRFLAKDGFMLNFMSVLQLLSVKINLSRIDPLYPHHPESLVEIEDETKLKFSSQEYADWLGTLKDVKDWEQHKFVTHCWFLTLHAHHLGIIPAIQRYNKLLRATKELQRMVDELNATKTQWENTPLARRNKQIRDRCVSQMNKLSKAKLSCDIAIIDPNVLSACMQFYSTVCEYMLYQIENRPIDGPFTNQQHPSTLVASENFCALPEWYIEDIADFILFCMQHSSSVIDYVDNSIITWILTLVCAPHLIKNPYITAKLIEVLFVTSPTIQTTSQRLYLQIINHELAQTALVSALMKFYTDIETTGQSTEFYDKFTIRYHISHLFKGLWESALHRQAFVNESKSGKQFVKFVNFFLNDTTYLLDECLEYLKRIHETQVLMMDDSGWNALTQEAQQSRQRQLVQDERQCRSYLTLARETVDMFHYMTIDIKEPFLRPELIDRLSSMLNYNMHQLCGPKCNDLRVRHPHKYGWEPRRLLGQLVDIYLHLSCDEFANALAADERSFEKQFFEDAANRVERIGIRSHRDVDEFRKLIHKAAEIYVKNQENADEFAEAPDDFKDPLMDTLMTDPVILPSGTIMDRAIITRHLLNSSTDPFNRQPLTEDMLKPATELKERIQQWIKEYRAQKKSS
The following text describes a protein:
Function:
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Domain:
The RRM domain mediates the association with collagen mRNAs stem-loops.
Sequence:
MAQLGEQTLPGPETTVQIRVAIQEAEDLEDLEEEDEGTSARAAGDPARYLSPGWGSASEEEPSRGHSSATTSGGENDREDLEPEWRPPDEELIRKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVTLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLHLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVDAAIKAHEFMVTESQSKENMKAVLIGMKPPKKKPLKDKNHDDEATAGTHLSRSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAASNKLSPSGHQNIFLSPNASPCSSPWSSPLAQRKGVSRKSPLAEEGRLNFSTSPEIFRKCMDYSSDSSITPSGSPWVRRRRQAEMGTQEKSPGASPLLSRRMQTADGLPVGVLRLPRGPDNTRGFHGGHERGRACV
The following text describes a protein:
Function:
The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKKKLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACTGLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGPWFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVVYRKRS
The following text describes a protein:
Function:
Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (By similarity). Involved in modulating physiological aging, probably by regulating expression of branched-chain amino acid transferase-1, bcat-1.
Subcellular Localization:
Nucleus.
Sequence:
MLMEDGGLDTTSEEYRKLSKAERRKRRRATPKYRNLHATRERIRVESFNMAFSQLRALLPTLPVEKKLSKIEILRFSIAYISFLDNLLQ
The following text describes a protein:
Function:
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway (By similarity).
Subcellular Localization:
Cytoplasm. Apical cell membrane. Note=Localizes at the apical cortex of epithelial cells and cytoplasmic, punctate.
Sequence:
MPNQSQHHLQPHPHHLRPQQQQQQQQQQQQQQHHRQQQQQNHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGLYYINHLAQSTQLEDPRQEWKSVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELNHITNDISYTERGMNTLYSVGEKINARQNGCYDIAEVQAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELSRQQISEENSDLASPFDRVCVASQTDLCGSTGDNLNGGARFAEMAKTKLQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIQQTRNKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQRLHPVHPGLQQQQQQQQQSSEVSLSPRSSLSMETPPASPMKYNPGADPTTPALKEEPTYANALPAPPAYTAPPPVPVSGVRARPYDLDSTVLDCMMLEAKLQKLNLGTPLNLAAAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKLEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPTFESLDLPSTSAAAAAVAVAASSSASNSIREESSDESTITSSQTSTLTRNQAPPMELQAQIAEEQPEQDGSDDDDDDDEEEDDNNKKIIREVAVGLMNSGCMLDTYLQNMKQEFADKETNTDCAFLPEKSRGQSQMMDDRPVKRSQTFTPSAAVSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHTKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLIAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGMSVPELPSEFTLPEANPIEEEEEEEEEDEDEFYNAAETAIAINTALVASNNRNKNLTDHLNRVSNYAAPKPPTIPAPPAASPAAPAGSNPPSATPSTTPATQATTTAVPVPADDNNPEQQRYDYVVDRTYGVEV
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MGDFNSNEDNNNPFNNVLYNPYIVDLYDTTNNNNNNNNNNNIISGFNCDSSIFTQQISNTNNELTIPLTQSIQNLLPPVQQQTQLFISPNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDINTSIDINLNQLVYSTPSQQITNSVQPIYQCATQSTTSNIDTNINTINDNNNNNNNNNNNNNNSVNNNLLSMCQDPTLILQIQQLLLQQQLLQQAQQQSVPLNIQVPTTTTPINQQHQALLVPQQKQFYGNVSDNSSPETNFSYASPSSPSSTQSQSSPYEQQPLSPNPTISLSSSISVTATTTTRPNATEKTKESSLKSKSKSNEKDKEREDEEEDDDDRPKKRKKFDKNVYKGVDLGDELLEITSEEFQAYKNNFFANASDKKTVSALNYQFRKIKNRESARRSRERKATHVDELEAKIAEIEKERDNYKKENERLRMELDQYKLQEKQKSAGSIFDYISIGSPTTQNFSKNFGIILFLFLFGSFILTNTTPNFFNTNNGVINPNLVYNANSNNNNNNNNNVNRFSVNGVHSTQQYFQSQRNPLSNLDEDSLESLTASQGVFSTHFVPEQPSILLNRESIRNWATLPQNSVASLSFEKDNALKTIENANLDKSKHNVISNLNQLQQQQPSSDELMIDQKEEKNCNNNNENNNNNDNNKNSDDEKGKEIEEIKRKSTTTTISPTRYVNNSTISLLVNPTSVIGDIPDDLMKNSNVTTFGENSSFKFNFLIDTQNFPNGSNDISKAFFDNENQQMTVTSVIIAIQKSPKTPSQQPSTK
The following text describes a protein:
Function:
Catalyzes the interconversion of serine and glycine; Interconversion of serine and glycine.
Sequence:
MDLSSQSTDTSSTLSLGLVSPSPPSHRSQIVDDSITLQLDTRDTTHPVPPVPLQLLEPQTENHNSLQNGKQKESESYNEDEESKEMEEFHILGHPMCLKRRRDSCSSSSSSSTKRMTVEPDLETRKATVKSWGSQPLHVADPDVFDIMEQEKKRQFLGIELIASENFVCRAVMDALGSHLTNKYSEGMPGARYYGGNQYIDEIETLCWKRALEAFGLDAENWGVNVQPYSCTSANFAVYTGLLLPGDRIMGLDTPSGGNTSHGYYTPNGRKVSGASIFFESLPYKVNPQTGYIDYEKLEERALDFRPKILICGGSSYPREWDYARFRQIADKCGAVLLCDMAQISGLIAAKESANPFDYCDIVTSTTHKSLRGPRGGIIFYRKGTKPRKGGMLLSQGDDNDQYDFEEKINFAVFPSLQGGPHNNHIAALAIALKQVATPEYKAYMHQVKKNAQALASALSRRKCRLVTGGTDNHLLLWDLRPFGLTGTPAMTSRGCLESDFETIADFLLRAAHIASMMQRDHGKLQKASLKSLHNNKDLLELRTQVETFASPPPHTTRPHLCLLKCWQNACENGFSMVLLQQFCGHTLVFGNIFPLIAILLVVFADLLNFDYKKLNPEFVSFLFLV
The following text describes a protein:
Function:
Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Located at the microtubule tips.
Sequence:
MFPLGSVVEVITGERGFVRYAGEVENRKGVYVGLELLPEFAEFGKNRGVVDGREYFKTKNNEKTGIFVPFDKCKLASSISSSPSPKIDGTAASIGMGFPPMSPNLQSSIPRLTNVSSSSNLSMNTISSTALTPTEKILQKRIEDLLYERQNHQQQLEEVLATVDQLQSLVTNFNDQQDEVDELRERITLKEERIQQMRNEASQRRFEFKTTIECLEESSNRAIETYENRIAELEAQLEMYMSGKSEDDLLFSLQQERDYALNQVEILQERVDTLMKQKANSSTANEKLSHMESSSPTLTNASFESPKRGKGSNDLPENHPQRRQTLEFYEIEIEVLREKVEKLQALSDEKDFYISKLEKSLDRNDTTPVPSDEKLSNYAAEKENLVSRISELEHTIEQLTINNERDNERMSPAEFELETTQEVEENDSDSHDDEETWCEVCETNNHSLQECPTVFGSTDEA