lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation. Negatively regulates telomere silencing. Telomere silencing is increased due to histone hypoacetylation and/or an increase in the ratio of methylated histones to acetylated histones. Telomeric histone acetylation contributes to normal meiotic progression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPATILKSTASSKTLLIIKFDTNSSRYPFYKKHLLELNSESTFLGLLTKGQADTSITRLNQDDVRLFEKAKTVADRTKDVAYSFSDPILSTQLRTPPPQPTSIRYLYFGTYRIKPWYTSPYPEEYSCAKNLYICESCLKYMNSDHVLQRHKMKCSWSYPPGDEIYRDKNISIFEVDGQRQPIYCQNLCLLAKMFLHSKMLYYDVEPFLFYVLTEFDGQECKVIGYFSKEKRSASDYNVSCILTLPIYQRRGYGVFLIDFSYLLTQVEGKLGSPEKPLSDLGLVTYRSYWKMRVAKALLEITTPISINAIAKSTSMVCDDVISTLESLSVFKYDPLKKKYVLQLKRDELENVYKAWNIKHPQRVNPKLLRWTPYLGEEQISNLLLKENILIPLPQKRLLDNSHHLDSV
The following text describes a protein:
Function:
Essential protein required during embryogenesis. Exhibits holdase chaperone activity involved in the stabilization of NADPH:protochlorophyllide oxidoreductase (POR) proteins against photooxidative stress during POR proteins import into chloroplasts. Required for chloroplast biogenesis and development. When expressed in yeast, triggers mitochondria-mediated cell death associated with the loss of mitochondrial membrane potential.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein. Plastid, chloroplast envelope. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Targeted to mitochondrion when expressed in yeast.
Sequence:
MSSSLLLSGSTVSSSFIAPSKPSLVRNSSKTSLLPFRNVSRSFKTVKCTVDSSYGGNVPTFPRTRVWDPYKRLGVSPYASEEEIWASRNFLLQQYAGHERSEESIEGAFEKLLMSSFIRRKKTKINLKSKLKKKVEESPPWLKALLDFVEMPPMDTIFRRLFLFAFMGGWSIMNSAEGGPAFQVAVSLAACVYFLNEKTKSLGRACLIGIGALVAGWFCGSLIIPMIPTFLIQPTWTLELLTSLVAYVFLFLSCTFLK
The following text describes a protein:
Function:
Tubulin-folding protein which is required for the development of the neuronal microtubule network. Essential for the development and function of neuromuscular synapses. Likely to promote microtubule formation by acting in the negative regulation of the microtubule-severing protein spas.
Subcellular Localization:
Cytoplasm.
Sequence:
MVGIIDEVQLFYPLGTRIKIGDNYGTVRYVGEVSGHMGSWLGIEWDDGLRGKHNGIVDGKRYFQTQTPTGGSFIRPGKVGPCATLEDAARERYLNYDSSNVDESLIREAQASLQASLFEVVGMDKIARKQSKFEQLEEVSVDQTPVNAAGYLKELTHLTTLNVSHTLIWNWEIVASIAQQLPSLTNLNLSSNRLVLPTSSQITELEPSFRQLKRINLRSCGFSDWKDVMHTALLWPNILSLGLQENSLGQLAEVDRTKIFKQLHELDLHRTNIMDFDQVTKLGNLTTLRLLNIMENGIEEIKLPDCDSQEKLNIFVSLEQLNLLHNPIWNEADAFNELDKLPQLKRLSKTPHLKSNFDEMFSKAVASIASLQFINKAEVTAEQRRGAEYDIWKKYALDWMQATQGGTDSLREFCRRHRTYPLLVKKYGSPADFVPRSQAKQSNLINVSIRHQLTGETWEKKVPRMITVQTLQGLVMKRFRLSGDVPQLCYVDALHPDLVVPLDNNAKTLDFYSVQEHDTVLVQ
The following text describes a protein:
Function:
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Sequence:
SNLQLSGASELTGAERIRHPEGAMEHEFRYEDYKETAEWLLAHTEHRPQIAVICGSGLGNLANRVTQGQAFAYSEIPNFPQSTVPGHAGRLVFGYLKDKCCVMMQGRFHMYEGYPLWKVTFPVRVFRLMNVHTLIVTNAAGGLNPEYEVGDIMLIRDHINLPGLGGQNPLSGPNDNRFGGRFPPMSDAYDRVLRQKAHGIWKQMDQDRPLQEGTYVMVGGPNFETIAECRFLQKIGADAVGMSTVPEVIVARHCGLRVFGFSLITNKSILDYATRETANHEEVLMAGQQAAKKLEKFVCILVENMQPPAEETF
The following text describes a protein:
Function:
Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSSAIVVSQDAESLGLQIYSRKEKSLGVLVSNFLRLYNRDDVDLIGLDDAAGQLGVERRRIYDVVNILESIGIVARRGKNQYSWKGFGEIPRSLDELKEEGMRERLGYSSSNNSDKVSNGCEREEPLTLTPDDQENSSSSKMDQKKEKSLWLLAQNFVKMFLCSDDDLITLDSAAKALLSDSPDSVHMRTKVRRLYDIANVFASMNLIEKTHIPVTRKPAYRWLGSKSIAERGLSLFNSGEPKRVFGTEITNLRAKRNKTYCSSIRKQIGYKKHDEENTEQESKPAASKYVFGPFSPIGASKTNNDKVGKGRLLEIEALASTYQPQYCNQEITGLLGHFTEAWKKWYAEVDRNK
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Zona pellucida.
Sequence:
MEVLYFHSGSLVSLFLALCVFLEEILGYPGVSTSAASPDDRVKGRQQRTAAELCSVRPADALACGEPQVGEARCRAKQCCFDSSVNPSCFYKNDVTVECTSDGYAVVAVSKAVTQPPLRLESLRLNEDTAAPCSSPASRTPGFVLFRFPLSSCGTTTKEIDNMLVYENQMSVSSRTAVITMDVDFHLTIRCSYPANKSLSVKAEVQSPTLPPSLTAYGPLHLELRIAKGTADQRAGCFKKSSGLVNESYSSYHPSSEDLVTLELQQPVPVEVRMVGRTDPNIHLILDDCWATATPSPFSNPHWNLLIDGCPPNEDLNSTKLIPVAVSQELRYPGHYKRFQTKMFAFLDPAENKALNDLIYFHCTATACQPSDLVQCNVSCSPGAEKSLNWSNMTLLLVNGGPVHLHAALN
The following text describes a protein:
Function:
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Subcellular Localization:
Peroxisome.
Sequence:
MFQASKTHLNELQIKCLEEIVIVIDKQDQIIGADTKRNCHLMENIDKGLLHRGFSVVLFNTQNQLLVQRRADAKYTFPGHFTDSCSSHPLYVPEELEEEDAVGVRRAALRRLQAELGIPQDQISIMDIIFMNRIYHKSPSDDIWGDHEIGYLLLVRKDLTLNPDPREVRSYSYMSQEDVQELLDRGTRGEEKITPWFRTIAEGFLLSWWPHLEDVSPFVEPDKIYGL
The following text describes a protein:
Function:
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSTPAIPQDLQLNPSQRTQSAFREQRRQKLKEHLLKRKTSFACKQENQMLLSDGDQRVRTSEGQIQEGKKVLKIKTEMADKENVGRPTGIKNNLTVEKNCIPLKPSNELTNSTLATDPPNSEDNNQTLPLLPVKDDPQSQHRTLSQTFHLKNNSKKKPVITEKPKHDANVPKKPVLGAYRGQIVQSKINSFRKPLQVKDESSATTKKLPATVSKATKPQPGDVSSITVKSDRASHMTSTTKFASTTSQIRHLVRPPIRSQHNKAQDAMKPGNSRMSANVTVQKGPREKELNTVLSGIKTSSSQDIKGDKTLSKSMAAGMVVRPASSSNTKLIEKSKSAGQRSHTTVKAAVDSRWTQPKETAEERKARLSEWKAGKGRILKRPPSSAVTRPEPETQNEQPVGSFWTTMAEEDEQRLFTEKVNKTFSECLNLINEPIEEMRHTIVDILTRKSQEKLKFGENIEETSAAEEKIQEAHTDDTGVDLESGKLEMENNPPRNVFQDCEKEQDDKVKDPTSDVKTPSTNTRAGCLIKYNVSTTPYLQSVKKKMQFDETNSAYKELKFLTPVRRSRRLQEKTSKLPDMLKDHYPCVSSLEQLTELGCETDAFVCRPNTALCGMFSEPDPTEEE
The following text describes a protein:
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MDFSFLKLVQWKSLCILACLHIGNTDASKTDEKLSQFLFSNYNKHIRPARTLGDVTNVTFYLTLLQLISVTEKSEEMTTSQYVTIRWEDPRLIWNPKDFGGVTQIRLPSQLFWKPDLVLYNNNDGEYDTTVPVNALLNHTGMVEWLPAAIYKSACKIKVDLFPFDWQNCTMKFRSFTYDKTELYITSAYNKVVVDKAAYRDNGEWTIIHCPIKTNEDVNDPSYQDISLYFIIQRKPLFYIINIIIPCVLISSLSVLVFYLPSGSSEKMTMSISVLLGLTVYLLLLAKRVPETSLGVPLIGAYLLFTMLTVTLSIIFSVVVLNIYHRTPSTSEMPEWVRSLFMGTLPDLLRMEKPLSTRRLLLQTERRKLDDPIVSKNPYTHIARQTERDALLTDAYVEQAIPTAEQNLIILEEYKRNQQLVSSISRRSQHLRSRRTNKANDFSENGRKTEKNRRHRKQRQSCHDDQSWKYHGDDLNTTQFLQENIPMNLSEDGWGKEPIVCPEKYLPRSKSCSFDSKKHCAYIKEYQNHGDIATSLPLLGDSHRNNYDQLKEDQGNANPVQDSFENEELYLYKTHNEKIWCSKPRRTDLKGQTRIRNRPRPFQNLRSPHLKPRENGYHSHNTKHTSGDIKSPNVTTYESLFIDEEEQDASHYNTPTSTGAANCFESVEFVTNECKSVGKLSEEALLAASAVDFIAENMKTTDKMKIMIEDWHFVATVVDRLLLWIFMLVFLAGTLYFFIKATLNAPPQHPFEDNDPKYAMCWKTDEHHKYHLLE
The following text describes a protein:
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Domain:
The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane; The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.
Sequence:
MSRTGMPVINFINFNQTGTCISMGTSEGLKIFNCDPFGRFYSDEDGGCGIVEMLFSTSLLAVVGIGDNPSMSPRRLRILNTKRHSVICEVTFPTTILAVKMNRSRLVVLLQEQIYIYDINSMRLLYTIETSSNPRGLISMSPSLENNYLAYPSPPKVINSGIKSNANTNNIGISARSSIAEGGSEYLDKGTEPLTDSSKAGADLNSVKASTETTISPGKEHSAGSGLNATSSSGTVKNGDVIFFNLQTLQPTMVIEAHKGEIAALALSKDGTLLATASEKGTIIRVFSVETCTKVYQFRRGTYPTRIYSLNFSDDNEFLAASSSNKTVHIFKLGKPNAENSSAAATNSDDDEGEADSDDGADDDGVGDSDDTRSTVSIESFDNGSHQTREPIVDSSRKTVGRMIRKSSQNLSRKAAKALGSYFPKKVTSILEPRRHFASLKIPIESGSNLKTICTIGEPLTLDISDYPELFSGSRTMAQSASISANSSDSSLTRNSNFVKMIPIRVVSSEGYMYNYVLDPERGGDCLLLSQYPLLMD
The following text describes a protein:
Function:
May play a role in trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. May negatively regulate cell-cell fusion by interacting with SLC1A5, the probable receptor on the cell surface of the fusogenic syncytin-1/ERVW-1.
Miscellaneous:
MISCELLANEOUS: The human genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit.
Subcellular Localization:
Secreted. Note=Also found in cell lysates.
Sequence:
MACIYPTTFYTSLPTKSLNMGISLTTILILSVAVLLSTAAPPSCRECYQSLHYRGEMQQYFTYHTHIERSCYGNLIEECVESGKSYYKVKNLGVCGSRNGAICPRGKQWLCFTKIGQWGVNTQVLEDIKREQIIAKAKASKPTTPPENRPRHFHSFIQKL
The following text describes a protein:
Function:
Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells.
Subcellular Localization:
Secreted. Periplasm. Host cell membrane; Single-pass membrane protein. Note=Exported from the cell by outer membrane vesicles. Also found in the periplasmic space.
Sequence:
MTEIVADKTVEVVKNAIETADGALDLYNKYLDQVIPWQTFDETIKELSRFKQEYSQAASVLVGDIKTLLMDSQDKYFEATQTVYEWCGVATQLLAAYILLFDEYNEKKASAQKDILIKVLDDGITKLNEAQKSLLVSSQSFNNASGKLLALDSQLTNDFSEKSSYFQSQVDKIRKEAYAGAAAGVVAGPFGLIISYSIAAGVVEGKLIPELKNKLKSVQNFFTTLSNTVKQANKDIDAAKLKLTTEIAAIGEIKTETETTRFYVDYDDLMLSLLKEAAKKMINTCNEYQKRHGKKTLFEVPEV
The following text describes a protein:
Function:
Along with dyf-7, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. Promotes seam cell remodeling during the dauer phase. Plays a role in positively regulating locomotion during the dauer phase.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cell projection, dendrite. Secreted. Note=Located at dendritic tips. When transmembrane anchor domain is absent, secreted in vitro.
Sequence:
MLAHTHRINKCLYGQNQMRNRHALLGALPPIFLLLLPLISCMKFDPERIAARLRIDEKWDQLDAFQSIKSRRGRQIQPKEISIQVTAPLFSSRLFDYGTTAGDEELPQALDVGKKLDLVHPISFFGSDYKTIYILSNGAVGFEASSRSYKSGILPSSTRFLAPFWNRNDLRNGGKVYYREVTKGRVLERGQSEIRYQYDKNVKVKSALIITWDKMQPLNTAALPEENTNTFQAAIFITANGTFANFIYSNIGWTQGAEAGFNAGDATNHFKLPTSGTPNIMYLEEYGNTGIPGEWMFELSELRVISCKSGIKGDTCDQECSNGEWGPDCAYCCHCSEGTCHPISGDCQRGCATCWDGVACQTRQEKCATKTQCASNALSFNDYDRCGEPIQRCQCLNGYKGDGYNNCEDVDECKTNSTICHKNAICTNTPGRYFCMCKEGFSGDGQNDCSQSFLFQYDTHHQLPRKKNSKMEWNLKKPLKIFGETTEKLTVTSTGLIAINEVNRDNGRLEDMQLVGIAPFFGPIDLSRNGAVSVEEVDDVEVLRRVTRTIGENYNDPTFVAKSALVVTFSNVTDGRQTKGNTFQALLIDGSNSKNEKMTFVELMYRDLPWASGAEAGILSSDASSSILLPASGTEAISQLSKNSNIKQPGTWLYRIDKAQLMPCAQPIQVPPYCDRLLSTAPRLPSKLLEEKKEGLTLPSPGAFLVDQPSETIVPTLVRGGGTVTRGRNVLTVTTSPIGNQQRQQTTKAVTRPRPNFSSTPHRPIVSLSDEDFELGPDAFEVTFPPFVTVQPELFRPNQRNGVQKSTQRPLPDFSIRTPLKEEATTSVPREKTSSAAPAHSPIEEMSENEESPFEAGSFDGEAVKFNEELEAIDKALQTTKKQRPELSVTPQPEDLSGDARVIETTEEDEEEAEISTETTTEMSSTTTTTKAHTTTTTMMIPTEAPPSIFVFTTTQKPRAQSTTQKRIIVQQPSIVVNSQPPKQRNDNQPTVNVGHAEEQSPRLAILLPVMIILAWLVILVCIGAVVCCKRRNSRESSQLRAMYGAAYGVRPTAYESKRKESTYEDHLERAARLSGQPALSGQQAGKVSLYGSYWNLEPLSNHSPARLSTQERQSPPSFVNNGYTNQTTRYTYAGHY
The following text describes a protein:
Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVLSIDKASTLDLNFSRHEEKTSQNSELDSSNVNVIKMSVDREALEAGKSYLFTLGRAPQQCSDVTSGSDNSLILKSVTEEDERPGLLASAFFKKSKAGGGGPSDTNYIRFLHHLTDNLLVKWESILLESRLYIQLPETSLHQGGRDSLVELLDIAEEQLGCSQVIIMFARERSDVAQLMRNFKFLGFETLPPGHQWLPPATDQFFMAYNI
The following text describes a protein:
Function:
Methyltransferase which catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Sequence:
MSPTQIKNSSQDLLQAQVDLWHHALGFVKSMALKCAMELQIPNTIQHHGGAMTPSELAAKIGLHQSKLPRLRRLMRVLTVSGIFAVHESTTADKEAVYVLTPTTCLLVSDEVKSNLFPILSLMLDSTVLVPFFGMNSWFLDEHSTSLFKKAHGLTFWEMADKNDSYNQSINNAMVSDSNFLMDIILRECGDVFLGINSLIDVAGGHGGAASAIAKAFPQMKCTVLDLPHVIEEAPTDGHVSFISGDMFKYIPPADALFLKWVFHDWGDEDCVKILKKCKEAIPPRDAGGKVIIVDMVVGSGPNETVTRETQVFFDLFIMFLEGIEREEFEWNKIFMDAGFSGYKIVTVLGVRSVIELYP
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MCRFFMRTQGPKCFDALYRLAHTCFNKCIEKRHKEAELNIGDNCCIDRCISKYWRILRYGALLKISEDGLFQFCTRSCKDTVCFELSIEKAVCMLLKSEDVALLMKLEDQKKTI
The following text describes a protein:
Function:
Part of an export system, which is required for biosynthesis and secretion of siderophores; Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIVQRTAAPTGSVPPDRHAARPFIPRMIRTFAVPIILGWLVTIAVLNVTVPQLETVGQIQAVSMSPDAAPSMISMKHIGKVFEEGDSDSAAMIVLEGQRPLGDAAHAFYDQMIGRLQADTTHVQSLQDFWGDPLTATGAQSSDGKAAYVQVKLAGNQGESLANESVEAVKTIVERLAPPPGVKVYVTGSAALVADQQQAGDRSLQVIEAVTFTVIIVMLLLVYRSIITSAIMLTMVVLGLLATRGGVAFLGFHRIIGLSTFATNLLVVLAIAAATDYAIFLIGRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYFQTLGVPLAIGMVIVVAAALTLGPAIIAVTSRFGKLLEPKRMARVRGWRKVGAAIVRWPGPILVGAVALALVGLLTLPGYRTNYNDRNYLPADLPANEGYAAAERHFSQARMNPEVLMVESDHDMRNSADFLVINKIAKAIFAVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTARMLEQVNDIQSNIDQMERMHSLTQQMADVTHEMVIQMTGMVVDVEELRNHIADFDDFFRPIRSYFYWEKHCYDIPVCWSLRSVFDTLDGIDVMTEDINNLLPLMQRLDTLMPQLTAMMPEMIQTMKSMKAQMLSMHSTQEGLQDQMAAMQEDSAAMGEAFDASRNDDSFYLPPEVFDNPDFQRGLEQFLSPDGHAVRFIISHEGDPMSQAGIARIAKIKTAAKEAIKGTPLEGSAIYLGGTAAMFKDLSDGNTYDLMIAGISALCLIFIIMLITTRSVVAAAVIVGTVVLSLGASFGLSVLIWQHILGIELHWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSIAALLGKWFWWPQVVRQRPIPQPWPSPASARTFALV
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Plays a role in the speed with which bacteria traverse human epithelial cells; disruption of the locus increases the speed of trafficking about 2-4-fold. FitAB binds to its own promoter better than FitA alone. The expected nuclease activity was not observed for the FitAB complex, perhaps because FitA (the antitoxin) prevents metal binding and thus catalysis by FitB.
Sequence:
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDEPVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD
The following text describes a protein:
Function:
Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKALYVHVPFCSYKCPYCDFLSLVNSPVSVRDYLSALKREINLYRELDVKLETLYFGGGTPTLLKPEELGEIIEEIDKVFGLSGVKEITVECNPETYRKKEFEELKKLGVNRISVGVQSFTEKGLRVLGRKHTVKDSLECLESLFEAGIENVNVDLIWGWPTQSLKDLEVELEHLKKFPVKHVSAYLLTLYEDTPMGLAFKRGEFKPLEEEEVVELHKMLSEGLRELGFKRYEISNWAKEGFECRHNLVYWKMEEFLGVGVSAWGFYENVRYGNTKNISKYVKFLKEDKKPVEFRVQLDETELEKERIMLGLRTTEGIEEKYLKFVPEYLRDFFEVKGGRLRIKEEHLLISNELITEVLRKYESSLNKV
The following text describes a protein:
Function:
Ligand-dependent coactivator of nuclear receptors that may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGISLSLRQLDYRDWFQRKISRDIYGNSTWLTGIDLQKELTGHTGCVNTLDWSADGEFLLSGSDDTRLIVWDVFNEYKPRHLISTGHVQNIFSAKFVPYSNNRQILSASGDKLIKLFDLDSSKEGGMDHGMETQTRCWSCALDSVKNIVPCDNGHTFLVCSEDGTARQYDIREPHVCNQDLDCPSILVNYNPYRINLYTITMSPSNPYYFAIGGTHPYAFLYDRRMVKKSFRDDWTMNTSPEKDCRCVRKFSPDGSCNSQGILDRYITCCQFSAANPNELLVSWNSDYVYLFHVHEDKSYTPTFNKIEDSNKKPSKPSLLQTQPLKRKNYSPWYKNNFGASTPASRVSRNPYTAAQPRKHTFYQMYENIEKFFTTENGGLYESIVSGRLSHFSRSIQYVKDAIYFLENYNYIPDSNGLNHSIRVSALRYWRACVSILALMDDTVSLEPNTIIQAGWGWLYDFMNWVTRYLLGISDHWALQMSPPTNVARQNFVLCDPDEPSRVLFSNPSEMIRAFARIDTNDLSSVRRFFWIHKVLRGCLLLISSDIYWEQFQPWDSSTSDVTSSQRLDDENGFLTLLEPPVNYENEVESSSGENIVSMYTGHSDLNDDDDDYQDEESYSYASDDDDESDEDSDEGPTLLSLRMKKRKAVEPNVPVNTHVKSYYGHCNVESIKNVNFYGQNDEYVMSGSDDGRFFIWDKLNASILAIIHGDSEAVNVIEGHPRCPTLAVSGIDSTVKIFNTENTPPSGCSRNHTSNSYKIIATNEMNRQQGSRDSYITSRMLSHLAYRAHLDDGFGHEVLDTDACSIM
The following text describes a protein:
Function:
Nuclear transport receptor that mediates nuclear import of proteins, and which is involved in sister chromatid cohesion. Binds specifically and directly to substrates containing either a simple or bipartite nuclear localization signals (NLS) motif (By similarity). Promotes docking of import substrates to the nuclear envelope (By similarity). Together with akir-1 adapter, required for the import and load of cohesin complex proteins in meiotic nuclei.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus envelope. Note=In interphase germ cells and embryonic cells, localizes to the cytoplasm and nuclear envelope, whereas in developing oocytes, it localizes in the cytoplasm and nucleus.
Sequence:
MTLTETSLSHNAEEGKDEGGRLQQYKNLTKHEELRRRRTECSVEIRKQKGADMMMKRRNIVDVDEGGNSESELEEPEKISHQQSSTRLSNDEIRAILSNNPSEDDMVRCFESLRKSLSKTKNPPIDEVIHCGLLQALVQALSVENERVQYEAAWALTNIVSGSTEQTIAAVEAGVTIPLIHLSVHQSAQISEQALWAVANIAGDSSQLRDYVIKCHGVEALMHLMEKVDQLGDSHVRTIAWAFSNMCRHKNPHAPLEVLRVLSKGLVKLVQHTDRQVRQDACWAVSYLTDGPDEQIELARESGVLPHVVAFFKEAENLVAPALRTLGNVATGNDSLTQAVIDLGSLDEILPLMEKTRSSSIVKECCWLVSNIIAGTQKQIQAVLDANLLPVLINVLKSGDHKCQFEASWALSNLAQGGTNRQVVAMLEDNVVPALCQALLQTNTDMLNNTLETLYTLMLTVQNGYPHKVDILHDQVEENGGLDSLERLQESQSEQIYTQAYRIITQFFTDDDAGEKESHENADPQDNKWSF
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.
Sequence:
MEDKPLVVSKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSNVANDISKPVLTTRVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLAMAVKDKSMERLKALKEVIRLCQVW
The following text describes a protein:
Function:
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MFSFFRRKKKQETPALEEAQIQETAAKAESELAQIVENIKEDAESLAESVKGQVESAVETVSGAVEQVKETVAEMLSEAEEAAEKAAEQVEAAKEAVAETVGEAVGQVQEAVATTEEHKLGWAARLKQGLTKSRDKMAKSLAGVFGGGQIDEDLYEELETVLITSDMGMEATEYLMKDVRDRVSLKGLKDGNELRGALKEALYDLIKPLEKPLVLPETKEPFVIMLAGINGAGKTTSIGKLAKYFQAQGKSVLLAAGDTFRAAAREQLQAWGERNNVTVISQTTGDSAAVCFDAVQAAKARGIDIVLADTAGRLPTQLHLMEEIKKVKRVLQKAMPDAPHEIIVVLDANIGQNAVNQVKAFDDALGLTGLIVTKLDGTAKGGILAALASDRPVPVRYIGVGEGIDDLRPFDARAFVDALLD
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MSARVVDKQPKKGGKGEESLELVTWMGRPPDKPTNCPAGLEYLTTLDKLRISQTYGPEGPVCNFENNDYVIKNGRGQQVYFASEETNCFCRQCCGPARAFHMRLYDKLSREVLHLVRPARCDACCCPCCLMTVTVKTGDGETLGYVKQKWNIFHGILEVQDADKKPWYHIRGPACPCRCFSNMEYKILSLEEDKKAVGSIAKRWGGPQDKYNMDHENFEIEFPFEVDVRMKAVLLGACFLVNYMYFEMS
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11. May play a role in cell growth and/or survival.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MEEQILPETDVAELELQAVIGFNGHVPNGLKCHPDQEHLVYPLGCTVLIQAINTNEQNFLHGHGNNVSCVTISKEGDYVASGQVTFMGFKADIILWDFKKRELIARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATSVVFSRCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQTKRIVMSSGMADDDSFFYLGTTTGDILKINPKTKLLADTGPMKDKFSLGVSALRCLKMGGLLVGSGAGLLIFCKSPSYKPIKKLQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEAVQDIVFPFGTAELFATCAKKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSLSGSVNGMDITQEGEHFVTGGHHHLIKVWDYNEGEVTHVGVGHSGNIMGIRISPGNQYIVSVSADGAILRWKYPFAS