lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MNSISSVFSSEQSVFIPYISLGDPDYDSCVIWADALIRGGAGILELGIPFTDPVADGPVIQKAFKRSLAHPFSMDKILEVTSEIHKLHPQIPLVYLTYFNPLFSMGLESFTERAKNSGIQGLIIPDLPFDTPEAEEFFSQLERKRIDFIHLVTPATTEDRIRSMKSLASGFIYYVTSYGVTGERGSIASGLEDRIRMVRKIVGLPVCAGFGISTSDQSKVISTYADGVIIGSAVQRIIEENGSDRNNCADKLLAYASEIRASMR
The following text describes a protein:
Function:
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAPLAEASAPVLEPVTVLKQKSVHEPEEPQSEASCEEDDDHNDASSSTAETETDDDDEPSTQQETAAAESEYVQQPAKKRVRFNEADVVEFEPTMWTATVSSEGVPIGMSVDVRRRTKRPLDTYENERVIQQRVDRQEYMELGYLEPEERLDILENAGHAISIISHVERETLRINRERWESNEYDLMYQYGLGEVPLMEDGDMDMMLQQDDADDIMHVDDSSEDDFFFGDSGRSMAVDSEVRFAMEDMDAYDAINSRTYDDLSIDYASDCILGDDESSDENNELPYAVDSFDSPLSCDLLEMGTSPSDVSAPSDCMLAAAAAATCAQSAAAAIKASREITPVIAIHAHVAPLSTFACTGGPMLKCDQRTRRCKSYAQAQQLTSPKLPLLMVLSSVARVSTHSLRCSRSLSTAAPFDPQVPHYDVVVVGGGLVGSALACQLKSSPVFKGKNVAVIEPSNPPVAPAVEEDSPDLRVFTITPASKKLLQRTGAWDLIADAHKADFKDMQAWDAMGDGFIRFDAKKAGKDVLGHVLEHRVLVRALHERMNQLAGDSEDSAPLKLYCPAKVKHFQRPTPVSGISEIGLEDGQRLKADLVVAADGGNSIIRTLSALGTWGWDYDQQAVVATVKTDRVNETAWQRFYPTGPVALLPMRDGYSSVVWSCSADMAKELTALSPDEFVERLNEAYAAPPMSPVPPEFPGIPVLSDLVKGVHHAANTIMSAAALTEPFVAPPKAVATVGHRFAFPLKLKHATKYIKPGLALVGDSAHTIHPLAGQGLNLGLGDVQALSDLLVEGVKSGESLSSEHFLQQYEDERMKANITMQLAMDGFKRMFGPTPDAVSVARNVGMGTLNAVEPLKNQIMKYAMGL
The following text describes a protein:
Function:
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Sequence:
MEIIRAKHMGFCFGVLEAINVCNSLVEEKGRKYILGMLVHNKQVVEDMERKGFKLVTEDELLNDMDELKEDDIVVIRAHGTSKSVHEKLKERKVKVFDATCIFVNKIRQEIEIANENGYSILFMGDKNHPEVKGVISFADDIQIFESFEEAKKLKIDLDKTYLLSTQTTLNKKKFEEIKKYFKENYKNVVIFDKICGATAVRQKAVEDLAVKVEVMIIVGDTKSSNTKKLYEISKKLNDNSYLVENEEQLDLSIFRGKEVVGITAGASTPEETIMNIEKKVRGIYKMSNVNENQNEFSLMLEEFLPNQEKRVEGVIESMDQNFSYLDVPGERTAVRVRTDELKDYKVGDTVEVLITGLSEEDDDQEYITASRRKIEVEKNWEKIEDSFKNKTILDAKVTKKIKGGYLVEAFLYPGFLPNSLSEISDSEEKVNGKKIQVIVKDIKMDPKDKKNRKITYSVKDIRLAEQEKEFAGLAVGQIVDCVVTEVLDFGLAVDINTLKGFIHISEVSWKRLDKLSDNYKVGDKIKAVVVSLDEAKRNVKLSIKKLEEDPWATVANEFKVDDEIEGIVTKVLPYGAFVEIKPGVEGLVHISDFSWTKKKVNVADYVKEREKIKVRITDLHPEDRKLKLGIKQLVANPWETAEKDFAIDTVIKGKVVEVKPFGIFVEIADGIDAFVHSSDYNWVGEEIPKFEIGNEVELKITELDLNNKKIKGSLKALRKSPWEHAMEEYKVGTTVEKKIKTVADFGLFIELIKGIDGFIPTQFASKEFIKNIRDKFSEGDVVKAQVVEVNKETQKIKLSIKKIEIEEEKREEREQIEKYSTSSSEE
The following text describes a protein:
Function:
Seems to function only as a co-chaperone, along with cpn60, and in certain cases is essential for the discharge of biologically active proteins from cpn60.
Sequence:
MAKRLIPCFNRILIEKIVPPSKTSAGILLPEKTSQLNSGKVIAVGPGSRDKAGNLIPVSVKEGDHVLLPEYGGTQIKLDDKEYGFEIVFCVSFTYWFLFIFLLLFCRFHLFRDEDILGILHD
The following text describes a protein:
Function:
Actin stress fibers-associated protein that activates non-muscle myosin IIa. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.
Subcellular Localization:
Cytoplasm, cytoskeleton, stress fiber.
Sequence:
MASNAALQGEDIPQPQESPPDTACMEAQKWIEQVTGKSFGDRDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNITLFLRGCKELGLKESQLFDPGDLQDTANRTTGRTSDCNRKLRNVLVTVYWLGKAANGCSSFSGTNLDLKEFEGLLAQIRKENEEIESPKRSIRDSGYIDCWDSERSDSLSPPRHGRDDSFDSLDSFGSRSQQTPSPDVVLRGSSDGRGSDSESDLPHRRIPDVRKDDMSARRVSFGENKAFVPFNQYLPNKNNQTAYIPAPLRKKKAEREDYRKSWSTATSPLGGERPFRSMSMCDMRYEEEGSMLPHSRAHHEHLQHVNSLLKEEDDTWQDDLARWKTRRRSASQDLIKKEEERKKMERLMSGDSELSDRRKSIKTYREIVEEKERREKELHVAYKNAKTRGEAERILKSYIEKFTISEAVLEGLVMPKILERSQSVEPSLLSSSEDPNPLKYLRQQSLPSPKYTSTVEATVTPSSPCESKSPTGLISPSKNIISKTVPMLTAKPYSQPKNTQEVLKTFKVDGKVNLNGVEEQKGKESGSQTFAAPSLTRSQMFEGVARVDAPVVETKQDVASIKLNLARPNTLNSLHESNSLCEDRNHISQKDEPDSFVQEESVHSVEQLSEGNTQSNSTTQAVPAVSSIEIPPLTVNGKDTEDKRKVEAAELIMHWSLDSNYKEAKKNSLPPLKSSENVEESSKIKENESSHKVQLNITLQTRNAWRRSQFFLQSVDTECTEKSPALVPNLSSPNRSCTWDPEEERKRQEKWQQEQERLLQERYQKEQEKLKEEWEKAQKEVEEEERKYYEEERKIIEDTVVPLTLSPNSNVHFNISERNGNFIPVLPDHAKRDQENNNGQLMAEPNRVIKNEIHMHSNVTQQQILYAHERSMLAAEETQIKGKTEKWEAEPCNHVQSNECNTPTRLTLQAGCKQVMLSESCDLGSPKTPVDENAVHHNMSSIISTRGIDSKEETLNSSQSTSQCQSPNRSVSGKKLCSTCGLPLGKGAAMIIETLSLYFHIQCFKCGLCKGQLGDATTGTDVRIRNGLLNCNDCYVKSRTAGHPTPL
The following text describes a protein:
Function:
ATP-dependent protein-folding chaperone for the eIF2 complex (By similarity). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MKKEQVVNCQFSVWYPLFKKHTIKSLILPIPQNVIDYLLDDGTLVVSGSENNNSQTQANNSDSDEEDIQWTDDETTTTVTAPEFPEFNVKVQEAINVLGGCIFPKLNWSAPRDANWIALNSSLQCQSLSEIFLLFKSSDFITHDLTQPFLHCSDDSPDPTINYELVLRKWSELIPGGEFRCFVKENKLIAICQRDYTQHYQHIGKQEASISTSILQFFRDNIQYQFPDEDFVLDVYRDSSGRVWLIDFNPFGEVTDSLLFTWEELTSGKNLTANQTQEETALPDGPAFRCTNSEVTVQPSPCLSYRIPRDFLDLTTGEDAYKLIDFLKLKRGQQEEEEESNEEGEEPQ
The following text describes a protein:
Function:
Plays an olfactory role that is not restricted to pheromone sensitivity.
Subcellular Localization:
Cell membrane.
Sequence:
MGCCRWYLVVGLGLGKVGTGLIFLFAWRDIFDILVTEEKSLLPGSTLYKEWRRPTERPSWQFYVYNWSNAQAILEHQASSASFQEIGPFQYEEVAEVVDVKYHQANGTLSYRKRTFFRPSGPHSTTTNGTESERIISVNFVALLASHFGHSMDYSVQRELSFMLHNFRQTVTVTRTIGQLLFTGYREPMMEPLRKLVCPTKRRSVACQDERLAYFRTFNVTRRASEVYSLDVGLKDRSKYGTVRSWGAASVPAAHGEFHPCDGFAGLTGEFFPSRIERDQAIVIVLPELCRRLTLEFDREQLVAGIMGFRYAVRLVRPFRSAQMSESNMQSCPDTSIRLGRYGILNTNECNGFPLYESDQAHVSSNESTSFSSDSDLLYYLLEPTTGTVIESNIDLTYHTFLRPNEHIALFQSVPELRIPLFRFARYYRLSELKAAKLRQLLHLLDVGHQIALAGCVAGLTIILLAVVYACWKAQRPSKTNNDQYRIIGMQLSDGGREHNLLK
The following text describes a protein:
Function:
GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins.
Subcellular Localization:
Cell membrane. Cytoplasm, perinuclear region. Endosome membrane.
Sequence:
MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETERNYSLIDKHLTLSARKKDTHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKTELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHIDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNELDLENSTDWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVSAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGPDGNHLAADRGNCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECLINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MAPSTSLNAEWAGWVQEAADHAANNGSRSCDTYRRAARAIRLHNQPLHHPKQALALNGVGEGIVRLITARLQEKCDATGDPFPTEPESLKGKRKKDTTNPTRPRKRAKEILTAEERALDPSSSEEEEEQEQRPSNNRTGSSAGQKKKGKPRQPRRRRKIEVLTPEERALDPSSSDPEPSLPPKTTRQASPAQPKTRTNQKKYIPKRRTGCWGILVGLSILTTERAGSFTKQEIIEHAQKYCDSSYTERGSRGGGAGNSGHYTAWNMKKLLAEGLSLSTPGRQAKFTLTQQGFELASILAEKEDLTLVPFDKSKLPDGNSMSLLETHVDSARDPLPAASSSKAPVTSTSNASNLNPCGPNPSSSSDTIHSASHQRANTTAQKSNNPQRKNSLPTIPDDPEIACLNTNSSQQSSRVSHNRGPFEFWYLDRAGLRVRNMDDADSRMHPRTFETLYQVEFAASQSSHPVKRSSIVDEAALRPSPMNSSEGHMMGWMYESKAIPSCPGFGLSTHSPTLSTSTTIPPPTLSSSYNKNNSAPHVPSASQRRRSSPSPDPPVNIIHDDSYCGLSAQTTISAGYQNRISPLDRLFKPSSSGSATPAGSVVSIPSEADPAAPKDLAPSARLKPPSRPGSCEILWSGAALSETVAGWSASESPDSLPVSGAVNSLASSRTVVDLSREASNLSHQSSSLDRSSSSCPLRNLKRTTSALSESRSSSDGLPSNRTRVNLKRTPSGLSESLLSRASDDVQPEVWKAGSYDICLVLDHREVRAINDRDAFYNLCVEKVSALASPGQPTIRVLQRALVLGDAIWIAVHRDSQREVVLDSIVERKRLDDLCASIKDNRFEEQKARLKRSGLRDPIYLVEAYNTQSNLDSYGQMIYTSKFETMLLNDFQLEATPDWKASVEFLVRRSEVLRDLHQTIDLSIIPDATIDRTTYLFHLADLRTKDAENSARYWVTTYGAFEVLNHKTATLTVRELWARMAHCLPGMSASKVASFVDHWPTPVSFWADLLAHTSAPLSDQTKADKYPWSWIDRHPNEPLPSALSHPDHPVEMSIASISSTQTSCSAYPANCANSRIGPALSKRLWELYTLSDYASVEPSL
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRAYIFQDEGDQRKPNDSKIEVSAEDLEAAKVSYRHHDGDLHTFADGLMKEYGFKNRDEVVVSRKGLGDRYDNMVKKFFEEHLHEDEEIRLILDGNGYFDVRSVDDRWVRIFVEKGDLIILPPGIYHRFTTTTDDYIHAMRLFHENPKWIALSRTDSTSEELDARKSYLNSIKKSVYV
The following text describes a protein:
Function:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPPLNTTPQTLTGDAPSPPPPHPKKRPNAFTKLMSVSKKSKPAPTAEDPQPSSALSRAKNAVKGWDPRNGLGVYLENPETNPEGRVVEWDEQFVVIRDKFPKASVHLLLIPRNPDLYFKHPLHLLSSDTAFLADCRKRVERVKALAAQELRRQFGHVSVADKPYQNALDELMCASDGSPTEEKIAALPQGRDWSKEIVAGVHTHPSMNHLHIHVFSRDMHSACMKHKKHYLSFNSSFLVQMDEFPLEEGSERFAPGDWPTWGMKCWRCDKGFANKFARLKEHLDDEFEEWKKE
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular Localization:
Endoplasmic reticulum membrane. Microsome membrane. Membrane.
Sequence:
MGLDALVPLAMTVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPIYQVLGIGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQAGCPFRPNGLLDKAASNVIASLTCGCRFEYDDPRFLRLLNLAQEGLKEESGFLREVLNAVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTDAFLAEMEKAKGNPESSFNEENLRMVVADLFSAGMVTTSTTLAWGLLLMVLRPDVQRRVQQEIDDVIGQVRRPEMRDQARMPYTTAVIHEVQRFGDIVPLNMPHMTSRDIEVQGFLIPKGTTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGRFVKPEAFLPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPAGRPRPSHSHVVGFLVTPSPYELCAVPR
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDPRTSQARPDTHLKPPNPHQRASPSSSASPSPTPRAPVAAHNTATVAESVTFQGTHPISVGAGTVIHPRARIYSYDGPVIIGEGCIISEKSTIGIPPSTPTSLPPTPKEVVPIRISNGVTIGPLVTVFPGAHIHSFVTVESLAIINRRVSLGAHSKVCSGCEVAANTVIKDWTVVWGSGAGSCQRRKRATGKMSSSVVAGQDLSAPDAKVVEDARLIVLQKEREVVARLIGSSASAGGRRK
The following text describes a protein:
Function:
Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation.
Subcellular Localization:
Cytoplasmic granule membrane; Single-pass type II membrane protein.
Sequence:
MSESSSDSDSSCGWTVINHEGSDIEIVNSATASDNCGLTLECSLVEQEELPVLYVGHGGEESSANNTSSVGETMLSSMRETKSAAEVEEAPSPEDNVYFGTTSDDSDIVTLEPPKLEEMGNQEVTIQEAPSSDDLNMGSSSSSQYAFCQPEPVFSSQPSDEESSSDDTSHEPSPAPRRRRNRKKTVSISESEEPPLAEPEDEPSKEPSKRHFSRGLNKCVILALVIAVSMGFGHFYGTIQIQKQLVRKTHEDELDGVKGYLSQRKQEQESFLDFKSLKENLERCWTVTESEKITFETQKKNLAAENQYLRISLEKEEQALSSLQEELRQLREQIRLLEDKGTSTQLVRENQVLKQYLEVEKQKTDSFLREREMLLEEARMLKRDLEREQLTAMALRAELEQFIPGQAQSRAESPSVQTEEKEVGLLQQRLAELEQKLIFEQQRSDLWERLYVEAKDQHGKQETDGRKRGSRGSHRAKSKSKETFLGTVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGSKRFRAPKEAATEKTRTAYSYSSYSQQEAPNQNQNCRRPSAQRDGGREKPSHSEEIRKNANSYTYKAKSDCRGTHSTRRVCSGMFECAGQEAISPVNKASPVRMNDFKQLIHWYLLNELETFHHWKELDQFISPFFPNGVFRHDQQLFADFVDDVKGYLKSIKEYRVEDGNLEKLDGCIYRHFGHVFALPFGPRSVYIKPCYYNSF
The following text describes a protein:
Function:
Involved in regulation of xylonate catabolism. Represses the expression of both yagA and yagEF operons. Binds mainly at a single site within the spacer of the bidirectional transcription units yagA and yagEF.
Sequence:
MPIIQSVERALQILDLFNEQATELKITDISKLMGLSKSTLHSLLKTLQLHGYIDQNPENGKYRLGMKLVERGHFVVGSIDIRQKAKGWLTELSRRTGQTTHLGILDGREGVYIEKIEGKLAAIAYSRIGRRLPVHATAIGKVLIAWLGEAELNALLEGYQYTTFTPATLASREALMSALAQTREQGYALDSEENEQGVRCVAVPVWNHESRVIAALSLSTLTSRVDDAELANFREQLQQAGLALSRALGYPA
The following text describes a protein:
Function:
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAAIGVHLGCTCACVAVYKDGRADVVANDAGDRVTPAVVGFLEKETIVGLAAKQSRVRNATNTIVKVKQILGRSYGDPHTQKHISESKCIVVEKVGKPKYEIDTGETQKFVSSEDVAKLIFSKMKETAQSALGSDVNDVVITVPFDFGESQKKALGEAATAAGFSILRMIHEPSAALLAYGIGQESPTGKSNVLVYKLGGTSLSVTVIEVNSGIYRVLATSTYDDIGGICFTEALAQHLASEFQRTYKQDIRGNARAMMKLMNSADVAKHALSTLGSSNCFVDSLYDGIDFDCNVSRARFELICSSLFNQCIDPIKKLLEQIGFKANDVNQVVLCGGSARIPKLQQLIKDLFPEVEMLSSIPPDEVIPVGAAIQAGILIGKENLSTDLDTITIECSASDILVKETDESGDNKFTVLLPSGTPLPARRQHVLQAPGHISSVCLELYESGGKSPVESKFAQIVLKDLQKKASGVHDILTVLTMKRDGSLHITCTDKDSGKSEMITVEETP
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MPIPKNRPMHVEEEVSSQTNTEILLFALVIILSVIFINFFFFYLCRCCVYFYHTLENQEGDDERPLIQHHMVNRSTGSLSPSVDRLGNVLGYDIPSRRRRSVVSKEALSCISLEIPYIKWLKKRKGHAKGESTFLDNRSENQSVIVQGQGETPSVIITYDVRRPNLGSTSFVEMSSALSNIYNTDASDGDSSDDSCLLEDEEDFCIICYADYAFDDILRVLPCEHVFHTQCIDTWMTTMKASCPLCNEDYYKYFLQMDAASSVTHENAAWSIPLSPGDSRTHSAETDRSLLSAMSVRNSRMPYIVSSTL
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MPLVRRKDPNSMEMRFMPRNKACRKLQLTLGEFRRVCIIKGIYPQVPPKKFAGDTSYFLRKDIVHLFHDPIIPKIREIAAQLKRIKRMKARANVLEAKLLQAQMPIISLDHVVLERYPTFKDALSDFDDALCLLFMFSRLSSEHAPQKIIDNCKRLCREWDAFIAATGCLVRAFVSTKGYYYQAVVQGVKVTWLVPHRFQLDVPDVVDFKVLKSFVEFYQTFAGFVLYRLYSVLLNGYQYPPAVQEEADYILRLVGNIRAHATASEVDLSLIYGPNGCDEPCDKNGGVRNLNPASVKPFIGQKHAISREVPREPLELVLLSGGADVFTYSSPPHGATHIIVDRPPHNIEGVVGARIDGCAYLQPQWCFDSLNWGTTLPHAEYAPGAVLPPHVSPFYDDSADADGYVPDRVKELDQLVREKNNMVDITTLSVAAVKGLQEHGLLEAKDEAAAKVSSVDSLATQLAKAHATSLREELNLGCDEQEASESESSEINPDDFYRKDTRTLDAERLSEETRMRRAMLNATKARIYDRMVKENEEIARRRQELERRRDELRHTIELEKAKVAMGVDLRPPALPNEDEQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDVDDLFGDSENVTLQAINVASPVKGLSKRIDELGASGCCQKIAWSKNGCVAYISPDGYTANLKVFSRDTETGKWDLRKDVPLDVPQGREQFPFVHLSWSHLGNDLALMDAAGRVMVFSCAMALDRMQFIRAELAHPEAEVDGVVGMHWLAIHPYEAKVRTHIVNDANHLTQAQNNIAWSTTRDGNKWQWHVKSHMFNDAFHPLDGKASLIYLKRHGELKLRFQQNDSSWQEVSAQSAPLMSTKEPFTHAAFSSNNDATLLLVAYDVARRLHLYRVEIVWNVPQDKRNANAGPFDKPVLNVSLLSIEDDCDPIGLINGDLRGAAAAQLTHLNFLPTTPEDGDGSSPTIQAIFCRPPNIISSDQLQENPYSVIVTSKKKSVGSISAKTISKLDRQPDFPLHSVVLATYPLWYNMLLAFSYNDGTIEFRKRGTMEVIMPDGNTETMTSLLQAGFAFPHAEPSLHVALSPSHCIAVCMQQDGTIKLRSMEYLAGGTLSSDDDDPRHSAALAALVLQSSSAANQYYSSDDVFSIIGSLSEKRTNDFIDLLFDGLQVNIDCGVHDQNGQHLVLLGRSPFFVKTLSAMNLLGLHGPANRSLSSKIAWINLNIKYITQILTTIMRMHGNIEKTSLRPEVVPQFIGICRWILHFMAYLMDDLFTIGRAIQDLPSQSLTRETLEQKMHALNKPAVLILLSAFPRAMMKLWHQPIGWVKKSAETLAGSAGPNQPPISLDIRKLYTPLYSAVNEVPFDYRWFDGLVNDTHNHVRAAYKRANLTDIQRNHIERELMLGHIPEILAPIAKRLVTDTLWNDKSGNGCLADKLDMGRLMFFDTTWLGFNESKRASEWHDTHVVDVCQKMIVRGTGKQEHPVTGSGQQMRGRSDSIQSTNGETVLGKKKAQLRQCTRCGAYMEDVMQGTPGYTPHHASWLMGVAKHCVCGNSWMLAPDKMRAK
The following text describes a protein:
Function:
Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall.
Subcellular Localization:
Cell surface. Secreted, cell wall. Secreted. Cell membrane; Lipid-anchor.
Domain:
Forms a U-shaped beta-half-barrel with a large hydrophobic cavity (2835 Angstroms(3)) which is large enough to hold a single phthiocerol dimycocerosate (PDIM) molecule.
Sequence:
MNDGKRAVTSAVLVVLGACLALWLSGCSSPKPDAEEQGVPVSPTASDPALLAEIRQSLDATKGLTSVHVAVRTTGKVDSLLGITSADVDVRANPLAAKGVCTYNDEQGVPFRVQGDNISVKLFDDWSNLGSISELSTSRVLDPAAGVTQLLSGVTNLQAQGTEVIDGISTTKITGTIPASSVKMLDPGAKSARPATVWIAQDGSHHLVRASIDLGSGSIQLTQSKWNEPVNVD
The following text describes a protein:
Function:
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MQNGVGSSGAKANLKIAIVHPDLGIGGAERLIVDAAVELASRGHSVKVFTAHHDPRRCFEETLDGSFGVHVYGDWLPRHIFYRFHALCAYLRCLYVAWAVVLLWGSFDVVIADQVSAVIPVLRWMRQARILFYCHFPDMLLAKRESWLRRAYRAPIDWIEERTTGSADLLLVNSSFTAAVFNQTFRHLRKKGVKPTVLYPAVDLKQFDIPPPSPKEQEGTLEESIMVADTLEGIGGLHKKSRIFLSINRFERKKNVGLAIRAYAIMRSQLPNAMGGASASSDGASSSTGVREAQDSTVKLVIAGGFDVRLRENVELLEELKALAQESGVGEDVVFVPSFTQTQKNLLLTASICVLYTPEDEHFGIVPLEAMAARRPVIACNSGGPTESVDHQTTGFLCPPTPDAFAAAMADLLQHPQLAEKMGHAARAHVERSFSREVFGSKLEHMVLQLANERGKKKAV
The following text describes a protein:
Function:
As component of a spoke-associated complex, regulates ciliary mobility by mediating a stable and functional assembly of the radial spoke 3 (RS3).
Subcellular Localization:
Cell projection, cilium.
Sequence:
MYQQEEYEVNNEGQEDVSKINALNLKWTLGFNFQLTDGVHNLTNEKRKEIFYPVAHTGVIYDYENNTQRLLQGHCNRITATAYCKFSDIIVTADCGPDSMLVVWDASTGIPKKTIFEPHPNGCQALDISQDGQFIVTLSKEANTDTDVQSLSLWEWNKDDEPCLITNEFDRRIKDYQYFVRFNSDDNTEFATTGKTRIVFWRREGEQKGFNYYSPGNIPSLKVLTQTVFIPDNTQVVTGTTDGHIIVWDISLIIEKVDTPKERRAIKLVDLMNKSKKPDGKKGSNSINILKIQDNYLVIGSSNGSIRFYDFQYRIIAWFEDAIIGSISNISFANTPMIEDNEDEDGFDDERKDKGENEPKFICPDFIVVDLDATITMLNYKLFEELDDEKKKGTTLMKSIVSPIIAMSCRPNSNVIGICCENGYLYEWNFQEKSSVLSILRVFDTDKENIPNCIDYSPDGNWLSVATKSGKIHIFDCKEKQWQNSVLEVSENEQGKPKVNMQVFSSDSKNLATMDADYAVSLFTIDHRQFDVNIPEKEWQFVGKHRIHHSEIKSIAFGESKNENDKKYYRLFSIGADMKMVEYEVLEIDYSKQKEKGQQINYIDRLKLKSIYPIEQETIPTACIWYPINMYKEDVLLTVNEEFKIKLWQFMKDNFKFCKKTCLGPIYGGAINKLLILNQNDAQNDYQDKYLAYSTKEKVVGIIKLPLEGNPNQTMGLIAHPDKITSISCSNDGKHFFSSGSDDYCVNVWSVNVQALEQIFATNPNEDPYPKLLEGGEDGQTHQDLKNFFYYSQIRSKDEHTTKARKLDGKVPLIAIPDMMRSMGYYPTNKEIENMQNEIRFSKYLDPGEQVEELDLNMFLKLFVNHRPVQGIGKSKIAESLNTLTKSLSDSAKEIAEQAKGQSVQPKTYNIDGIGEISLQDLKKILTTEGERMTNEEFDECLKILCGENEDQIPQQINVNNLCEDILGFEDLEGEERDDNIEDQYEDEENEEYDQD
The following text describes a protein:
Function:
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MYLARAASRARFAGANAPAAPLYTRYCASTTLVARANASSLVSARLSAPISAASLPVRGAIGRIHRIPASAVNLHPASRWSSSAALASTSPEAAKVAEDAEQETENDPFRKIGYLYFDTVFPIRLGFWDIRYMLASLEKCSVLDRVKASLPPDQSVGYGFKVIGAEERMKDGGAFVTFSYLEDPNETNEESLDTIEKRLKSGVRRVFNPSLFFLGTPGVHVVRGKPFREDMNIFPATRIFVKLEGGDASEEQLWQTLRPYGRIVSIVKEKPSEALITFSRIRGATSARNCAHGLELPNGARFVITFRSMLRSKQAWDWISNHPRLVFPLVAFLIGGISYIVFDPVREFMVESKVHNTFSLEEYRVYAWLKQNTVGLFTNTDGDAKGDVDDWWERRQSAETIQEWIREKPSTFVTISGPRGSGKTGLVNRVITRDVQHLVIDCDVIAKTAKNDSLLIDALANETGYWPVFSWLSSINNMIDLAAVGLIGSKAGFATPTDAQLKQILGVVTNALNHINEQTQKRIVKAEKARLAAEKKQSASQTLYPAPGVPTVHNGAVGEKESLGEKASELAQNTIESLQHLVTCEDDSIAKKDKNTTFVSPVVVIKQFHHKGIKQAILHQVLAEWAAELVTNGIAHVVFVSDNPVGMGKELAKALPNVPFQGIALADAEEDKAQSYVYNKLKEMGRLPALGGAAPSWHPAYESNATRAQATAAEFAAANADYTTNGSAAASSEPQYAPTLDDETASWVDKLGGRLTDLETLVQKVSLGQTVESAVQDIISRSVVELRKNAFGDDSGEASSLPWTRSQAWTIVNKLAKTGEVSYYGLLHNEFKGNETAIKSLEQAEIISVRHHDGRPSAIRAGRPVMQEAIKRLVSDRVFNDTQTLLANTGAIESAEKSLRTIEAEIADISKMIQGSPFKVTSGAGSTSGAVLPPPADDKKESASGGLLGIFGGGSAGVAPISTSEAAKARTEFLMYKMAELQTKISKLDAQNTSIKARLASHMD