lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Positive regulation of conjugal transfer of Ti plasmids. TraR activates target genes in the presence of AAI and also activates traR and traI themselves.
Sequence:
MQHWLDKLTDLAAIQGDECILKDGLADLAEHFGFTGYAYLHIQHKHTIAVTNYHRDWRSAYFENNFDKLDPVVKRAKSRKHVFAWSGEQERSRLSKEERAFYAHAADFGIRSGITIPIKTANGSMSMFTLASERPAIDLDREIDAAAAAGAVGQLHARISFLQTTPTVEDAAWLDPKEATYLRWIAVGMTMEEVADVEGVKYNSVRVKLREAMKRFDVRSKAHLTALAIRRKLI
The following text describes a protein:
Function:
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
Sequence:
MAPPPTAAAAVRCHPHILRRGLLPASSPLLPFASRLASSTPLRAQPLRFSLSPVPKSISSSSTSHIPVRSLFTGIVEEVGRVRRIGPPPTPPGGGGDAAPGVDLEVETKNLLAGTQLGDSIAVDGTCLTVTAIDAAASTLTFGVAPETLRCTSLGERVASDDVNLERALTPASRMGGHFVQGHVDGTGEIAAFRPEGDSIWVTVRAPPEILSLLVPKGFVAVDGTSLTVVNVNEEAGWFDFMLVRYTQDNVVLPRKKVGDKVNLEADILGKYVVKLLAGRLEATSKANS
The following text describes a protein:
Function:
Probable thiol-disulfide oxidoreductase that may be involved in the redox regulation of chloroplastic enzymes.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAATATACPAPPPPRSLYRGVALAAPGRRRAGYGASSSAARRWPGCRRRWAAHRIRTVSCAYSPRGAKTITACSWNEYVICSDIPVLIEFWASWCGPCRMVHRIVDEIAQEYAGRIKCYKLDTDDYPQVATSYSIERIPTVLLFKDGEKTHSITGTLPKAVYVRAIEKSISDSEQ
The following text describes a protein:
Function:
Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli.
Subcellular Localization:
Nucleus.
Sequence:
MGSVLPAEALVLKSGFKPQGLSLSEIITSDILHSFLYGRWRNVLGEHLFEEKTGGVNPKTAFTAEVLAQSFSGEVQKLSSLVLPSEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVISPEHVDLFKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGNSIFYKAVETIPPDQELLVWYGNSHNTFLGIPGVPGIEDEHQKKQKTDDFHLCDGSSSSASSSSSSSASSSSSSSAASSRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCHVCQSAYSQLAGLRAHQKSARHRPSGTGAVVSLQAHSPPPPQMPPVPHPVSLAHHIPTMVL
The following text describes a protein:
Function:
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
Sequence:
MMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTAEMLIEWLQNQMTNGHLPGNGDVYQERLARLENDKESLVELLSRTSLETQKLELMAEISNLKLKLTAVEKDRLDYEDRFRDTEGLIQEINDLRLKVNEMDSERLQYEKKLKSTKDELASLKEQLEEKECEVKRLQERLVCKTKGEGVEILDRDIEVQKMKKAVESLMAANEEKERKIEDLRQCLSRYRKVQDPAALAQGQEGECEGLFHSSSISTLLDAQGFSDLERSTSSTPGMGSPSRDPLHTSAPEEFHTSVLQASVPSLFPTSMDEETCEKPKLATKPETSFEEGDGRAVLGADAEVSLSDGVSTSSLQKSSSLGNLKKETSDGVDKTPTDSHTFGTLPPKAPGHGASVDDSPFGTRKARSSFGRGFFKIKSGKRTASAPNLAETEKETDEHLDLAGTSRPKGSQGTSPFQMSPPSPDSRKKSRGIMRLFGKLRRSQSTTFNPDDMSEPEFKRGGTRATAGPRLGWSRDLGQSNSDLDTPFAKWTKEQVCSWLAEQGLGSYLSSGKHWIMSGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEETNYGKLDFNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENSITPSEVQQWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLTFSNFGNLRKKKHEDGEEYVCPMELGQASGSSQKGFRPGLDMRLYEEDDLDRLEQMEDSEGTVRQIGAFSEGINNLTCSHS
The following text describes a protein:
Function:
Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.
Subcellular Localization:
Lysosome.
Sequence:
MLIVEGTMKNIVAILCVLLHVSNSALSEKPNVLFIVIDDLRASLGCYGGPIISPNIDQLASKSALFTNAMVQQSVCAPSRTSFLTGRRPDTTRLYDFGSYWRRHAGNYTTLPQHFKENGYFTASVGKVFHPGVTSGGHDDYPYSWSVPPYHPPTEQYTGAKVCPTLDGTLHNNVMCPVNVSVMPQKSLPDIQSLEFSSSILKNLSVALHPTNKQGKPIETGQPSQDMQPPFFLAVGFHKPHIPWKYPEEFKSLYPIESVSIATNPYRSPTQPDVAYEDYYTMRTYREDVKAMNMSFPFGTIPLKFHAPMRQSYYAAASYTDSLVGKLLQTLNETGFSNNTIVVLFGDHGWQLGEHAEWCKYSNYELATRVPLIVHIPGVTDKPMSSPIKNQLQNSLKMIQSQDNVKLSAASGMVVAEFVELVDLFPTLSDLAGITVPPVCPPEPFNVTLCSEGYSFAPLLEPVQGSNTILQKDGMKKLTSKRYSRWKNATFSQYPRPGVIPNKKTDLPSLGDITVMGYSMRTKDHHYTEWIGFNPKNFQGNWTDVKATELYFNGLDYDQNQNVAADPQFKDIVKQLSYQLQMGWRESLPVPA
The following text describes a protein:
Function:
Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). Can also use hexanoyl-CoA as acyl donor in vitro. DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis.
Sequence:
MSGRRPTLLVFCDSLSYYGPRGGLPADDPRIWPNIVASQLDWDVELIGRVGWTSRDVWWAATQDPRAWAALPRAGAVIFATGGMDSLPSPLPTALRELIRYIRPPWLRRRVRDLYGWLQPRLSPVSRNALPPHLTAEYLEMTRGAIDFNRPGIPVVAALPSVHIADSYGRAHHGREATARAITEWARQHGVVLVDLKAAVADQVLNGRGNPDGIHWNFEAHQAVAELMLKALAEAGVPCR
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MAPAESGEKATSFAMACSLLSRYVRQNGAAAADLGLAIRAESDAKRTSTDMEKGETGKETMDLFPQIAGFGSEAATKEAPDAREPEKRQLTIFYGGKVLVFDDFPAEKAKDLMQMASKGSPVAQNPGLLPPSTAATVTDSTKIAAVPAAPIAVANAQKSAADIPQAPKASLRRFLEKRKDRLTAKAPYPGSPSDVTPVKKEMSDGQPWLGLGPQIANPDLSLSKEASQ
The following text describes a protein:
Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MATAIVRSALSRAVTRAAPKTSVAPKRNFSSSAGHDDAYEAAKWEKITYLGIASCTALAVYVLSKGHHHGEDPPAYPHMHIRNKEFPWGPDGLFEVKHNKEH
The following text describes a protein:
Function:
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Domain:
The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity; The TBM domain mediates interaction with TERF1.
Sequence:
MSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK
The following text describes a protein:
Function:
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
Subcellular Localization:
Periplasm.
Sequence:
MKWPRPYRRAFASSGVSMLNRVGLIVRGLAAVLLVLVSARVAAAEEKRLPVPAVSIRAGELIRDDMITERAFAPNLLGVAQFIEGRQILVGRMARRALLPGQPIPTNSVEDPWTVARGAMVKVVVEDSGLSIVTYGSAMQSGAAGALIPVRNTDTGVIIRGVVQPDGTVKVVDGS
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MAMPLLLAPVSSISSRSLALVLVLVLAAAALCRPGSCVDGAAAAADRIRRLPGQPEVSFGQYSGYVGVDDDGGKRALFYYFVEADVDAASKPLVLWLNGGPGCSSLGVGAFSENGPFRPSGQVLVKNEYSWNKEANVIYLETPAGVGYSYSADAAYYQGVDDKMTAMDNMVFLQRWLQKFPQYKGRDLYIAGESYAGHYIPQLAEAMVEFNKKDRIFNLRGVALGNPVMEFTTDFNSRAEYFWSHGLISDATYRVFTSVCNYSRYVTEYYGGSLSPLCARVMNQVTRETSRFVDKYDVTLDVCLSSVLSQSKILSPHEQVGQRIDVCVEDETVRYLNRRDVQAALHARLVGVDKWAVCSSVLQYELLNLQIPTINIVGSLVKSGIRVLVYSGDQDSVIPLTGSRTLVQNLAHDMGLKTTTPYRVWFEGQQVGGWTQVYGGGALSFATIRGASHEAPFSQPGRSLVLFRAFLQGQPLPETFS
The following text describes a protein:
Function:
Component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase and is required for the efficient segregation of telomeric and nucleolar regions. Although BNS1 can partially compensate for a lack of SPO12 function when overexpressed, it does not appear to play any role in controlling meiotic nuclear division.
Sequence:
MSYGGSASQDIVTKLIRKIQNTSVSCTRRDENLDSFNQHLKMSLKVAHNTKTFAKHCLHRQVFKNTYRKRKAVEDQRKNLNTQLRQKFASPSDNLLSPCSRKLNDHKSKLFSAKSQPKTLEFVRGKQNIPRKPNVDI
The following text describes a protein:
Function:
Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis (By similarity). Involved in the development of the sporozoite in the mosquito vector midgut (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MFVWTHINKYTSRYINRYILKFTRYESLRLCMLNFTSTIKNENKIYSKKNFNNVLMQNIKITEDEEIICEQFFFSKYNLPYVLKIPFSDLRLIDTCNNNHNPTILIRKDMILLRTGFLSCVIRYNELWLFEPREPLVIKATNLIKQNLKIIYGFKGDMSSGVEIPLNELKDEKCQENVNMYEKNIRNDLYSTYEKNISDDINDAKQKNMCSDINNIWSNHIKIDKKRIISGNYSRLNRNNIWENDREINKKDIFNIKEKKNMNENDDICNKIKIVGKEELNNNIKEDINYLNVENNFYRYKGNISFEFLCLDICMQLSIKEYENYLDTINITLRQKIQLQQKKEENIEINMLTNNLLREMMKIKNKLQKLSNLLNALRSNIEKILKNETDMKNMYLTTLNKISINKIKDYSDLEILLETHLQLTDELSGELENMEEKITHYEELMRLNLDYNRNKFILLNAKISFSTLFCSICAVITSLFGMNLKNFIEHNDYAFFIVSIFITSWSIVGIYFTKNINTLLRFFDKYNVK
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MENVPNPKRTVTVQMLPQLASIDVLGNKELNANWDIEPKLTLNQDCSSGQKTKADQDNMHLKSSVKDSHTALLEGAVLEDKNMSCHDSEDHRRPQNSHTNIKTSGQIVTDCDTNLNSHNINKEKNGNSTTKAPVVEEKRASKETMHNETPSLQKNSSPSDKIKSHLSESKDMSCTTSITTTASTSNTPSSAETLVSIQQPLKNQSTTAKEDTCSNDCKDFKPPGTASGLPVASTNTSHSVCTEAIDEEVQTQGAAPEVHCKLYREASTMTSAVDFGNQRHDAEVQAVVTVCSQSTATSPSLLSQQVQQRAVGPLPEETDSISVVVEVKTTSEIHCSTPSVVSKPSQSGTVMVHVDADLQKESKLGAKPKEPLQNGQRGLSQLQPVYQINIETCSQSKQSNETTCHLQSQAASTTAPQNAVKVSNKTDQDLQQKPTKTPTSKSEGVSAKLPMDITTATPPTSSSTPQSKKKLGAKKLMPEKDDQDEEENAKQSKKSVHDVVWDEQGMTWEVYGASVDPESLGFAIQSHLQCKIKEHEKKIIAQTTFRKSLSSPPGKNSKRRQVNVNFRSMFQNVRRPNCCARPSVQE
The following text describes a protein:
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Subcellular Localization:
Nucleus.
Sequence:
MPKRKAEGDTKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAAPKKSEKVPKGKKGKADAGKEGNNPAENGDAKTDQAQKAEGAGDAK
The following text describes a protein:
Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
Miscellaneous:
MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes; MISCELLANEOUS: Loss-of-function mutant (antisense inhibition) displays impaired granzyme B release and target cell killing by natural killer cells.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein. Synapse, synaptosome. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).
Sequence:
MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCMKNLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCVKK
The following text describes a protein:
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane. Note=Localizes to the centrosomes in a microtubule-dependent manner.
Sequence:
MAAAAEGVLATRRDESARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR
The following text describes a protein:
Function:
Acts in the coenzyme Q biosynthetic pathway.
Subcellular Localization:
Mitochondrion.
Sequence:
MKIVVLGGSGFLGHNICKLAIAKGYEVVSVSRRGAGGLHNKEPWMDDVEWETLDAQKDPNSLLPVLRDASAVVNSVGILMENNYKKILQNPRGPVSHLINSLSSNMFKTGQNPLAPKPEEAKQSKNKVTFEAINRDLAIETAKIAAKANVPVYCYVSAHAAAPGLDPRYIKTKREAEREISKISNLRSIFLRPGFMYNFNDRPFTGALASLFTVSSSINRATSGALNFLGTASAEPLPSEEVALAALEAISDPSVKGPVEISELKSMAHKFKQKSL
The following text describes a protein:
Function:
May play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.
Sequence:
MAVNQSHTESRRGALIPSGESVLKQCEDVDLCFLQKPVESYLFNGTKKGTLFLTSYRVVFVTSHLVNDPMLSFMMPFGLMSDCTIEQPIFAPNYIKGTIQAAPGGGWEGQAVFKLSFRKGGAIEFAQLMVKAASAAARGIPLGSVNYWFDTSGLYIITVPGAAVCSSQTPCPAYPIVIYGPPPPGYTVQPGEYGTPPEGYGAQPGGYGAPPMGYGAPPVGYGVPPGGYGVPPGGYGVPPGGYGAPPGGYGVPPGGYGAPPGGYGAPPAGYGAPPAGNEALPPAYEAPSAGNTAASHRSMTAQQETSLPTTSSS
The following text describes a protein:
Function:
Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.
Sequence:
MKTAENIRGTGSDGPRKRGLCVLCGLPAAGKSTFARALAHRLQQEQGWAIGVVAYDDVMPDAFLAGARARPAPSQWKLLRQELLKYLEYFLMAVINGCQMSVPPNRTEAMWEDFITCLKDQDLIFSAAFEAQSCYLLTKTAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLFLDCPLETCLQRNGQRPQALPPETIHLMGRKLEKPNPEKNAWEHNSLTIPSPACASEASLEVTDLLLTALENPVKYAEDNMEQKDTDRIICSTNILHKTDQTLRRIVSQTMKEAKGNQEAFSEMTFKQRWVRANHAAIWRIILGNEHIKCRSAKVGWLQCCRIEKRPLSTG
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Sequence:
MTSKTNLLAITLAVAAISSDFCSGTATAVESTLKIVRSEPEVGRMAKDFELEVAAGQRSGTVRLSEITGEGPVVIAILRGFPGSQCPACAGQVADLVRHAHYFQARNAEVLLVYPGPASELKAKSKDFLEDTKLPAPFTMLLDPDYQLVSDYGLRWDAPHETAYPTTIVIGKDGKIDFVNISRTHRGRTTATTILDQL
The following text describes a protein:
Function:
Required for the translation of the chloroplast petA and petD mRNAs. Required for the processing of the petD mRNA from a polycistronic precursor. Binds with high affinity to the 5'-UTR of the chloroplastic petA transcript. Activates psaC and petA translation by binding their 5'-UTRs.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MPASLLPPTFLPHHLRRLAPAGCTTSSVTSSSVSIPASRYDFEPLLAYLSSPSVSASLTSPSPPASVPAPEHRLAASYSAVPSHEWHALLRDLAASDASLPLAFALLPFLHRHRLCFPLDLLLSSLLHSLSVSGRLLPHSLLLSFPPSLSDPPSPLLLNSLLAASAAASRPAVALRLLSLLREHDFLPDLASYSHLLASLLNTRDPPDAALLERLLGDLRESRLEPDAPLFSDLISAFARAALPDAALELLASAQAIGLTPRSNAVTALISALGTAGRVAEAEALFLEFFLAGEIKPRTRAYNALLKGYVRIASLKNAEQVLDEMSQCGVAPDEATYSLLVDAYTRAGRWESARILLKEMEADGVKPSSYVFSRILAGFRDRGDWQKAFAVLREMQASGVRPDRHFYNVMIDTFGKYNCLGHAMDAFNKMREEGIEPDVVTWNTLIDAHCKGGRHDRAAELFEEMRESNCPPGTTTYNIMINLLGEQEHWEGVEAMLSEMKEQGLVPNIITYTTLVDVYGRSGRYKEAIDCIEAMKADGLKPSPTMYHALVNAYAQRGLADHALNVVKAMKADGLEVSILVLNSLINAFGEDRRVVEAFSVLQFMRENGLRPDVITYTTLMKALIRVEQFDKVPVIYEEMITSGCAPDRKARAMLRSGLKYIKHMRVA
The following text describes a protein:
Function:
Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
Sequence:
MLPTIITDIECLVTRPDRHNLVTVVVHTNKNVTGYGCATFQQRPLAVKAMVDEYLKPLLLGRDANHIEDLWHMMMVNAYWRNGPVINNAVAGVDMALWDIKGKLADMPLYHLFGGKSRDAIAAYSHAASDTLDGLYQEVERLYAQGYRHIRCQLGFYGGNPDALHSTRQPTEGAYYDQDQYMANTLAMFRALREKYGDRFHILHDVHERLFPNQAVQFAKAVEVYRPYFIEDILPPAQNEWLAQIRSQSAVPLATGELFNNPAEWQNLVINRQVDFIRCHVSQIGGITPALKLGAFCQNFGVRLAWHCPPDMTPIGAAVNIHLNIHLHNAAIQEFVAYPENTRKVFPQAVEPENGYLYPIERPGIGVGIDLDAARQFPVVYRPHEWTQSRLPDGTMHTP
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of a tyrosine-derived cytochalasan acting as a fungal signal recognized by resistant rice plants and leads to avirulence in Pi33 resistant rice cultivars. The first step in the pathway is catalyzed by the hybrid PKS-NRPS ACE1, assisted by the enoyl reductase RAP1, that are responsible for fusion of the tyrosine precursor and the polyketide backbone. The polyketide synthase module (PKS) of ACE1 is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the tyrosine precursor. Because ACE1 lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase RAP1. Reduction by the hydrolyase ORFZ, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ORF3 then yield the required isoindolone-fused macrocycle (Probable). A number of oxidative steps catalyzed by the tailoring enzymes identified within the cluster, including cytochrome P450 monooxygenases CYP1 to CYP4, the FAD-linked oxidoreductase OXR2 and the short-chain dehydrogenase/reductase OXR1, are further required to afford the final cytochalasans that confer avirulence and which have still to be identified (Probable). The monooxygenase CYP1 has been shown to be a site-selective C-18 hydroxylase whereas the function of CYP3 is the site-selective epoxidation of the C-6/C-7 olefin that is present in some intermediate compounds. Finally, SYN2 and RAP2 are not required for avirulence in Pi33 resistant rice cultivars.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLSLLETKIIEPFMVVRQTLAPLRLSRWQIFKHMTRILIFSSNTRTIIFCVLMSLVGYIVSRIIWGRQEKYPDHGLPIVKTNDYHFDNIVAEGKRLYPNQAFMGINKRYKFVIYPSSSWEELKRIPEQTASIMDFQHVCNSGEWSLVGGETHELVKTITAELTRSLPARVPNRQQDAKMTFDTIIGHCPEEKGFNLLMTSLEIIAKINACTFVGRELGANKSWVTAVVYSPLWVYFAVTLCNATPDILRPLLRPLFFLPALRNYWNMQKLLKPKLDREMETFRQTDDKRKLLVPKSDQDLPFTHFLLSRYTEAAATIKQLVIDYIQVSYTSTPTTASALFHALWELAQHPEAAEVMRRELATVMIDGNLPKTHLQELKRMDSFLRESFRLHPITRFTLQRYVKEPFQLSDGSRIPPGVMAVVDAQEINRSPEIWENPDEFDMDRFYRLREISGNDNRYHFVTTSSNSPGWGDGTQACPGRFFATSTLKIVMAHIVMNYDVSLRKVAPLKSQPLVNGSYSPDDSVEIFFKSRNVE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASDPMSVNSSAREPPAPPGSGADEPKYGGYTRFELELEFVQALGNPLYLNHLASRKLLSNPAFIAYLDYLQYWSRPPYLKYITYPGPTLKNLELLQQEKFRQDIISPDLVERLRLEGMKAGIDWHRESFPSTA
The following text describes a protein:
Function:
Component of the Set1C/COMPASS complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNESENSPQHNEVTVPMVEDTSSNADIPMEQIQREDNKNYDKHDNECFDMNGNHNNNSDNLQFDSVPSSATKDLKNIKSVTNQNVKIEESSSTNSVIEESSEPKISKLENVNLAATVGGSQTRKYLNTNVTPHLLAGMRLIAVQQPEDPLRVLGEYLIEQSNILKSGEKESNASK
The following text describes a protein:
Function:
G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes. Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium.
Sequence:
MAAARPARGPELQLLGLLLLLLGGPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSALAPMAWAHGRRQGLGPIHSRTNLMDAELMDADSDF
The following text describes a protein:
Function:
Protease able to cleave casein in vitro.
Subcellular Localization:
Secreted.
Sequence:
MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYIIEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLTEVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEASIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESFNAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQLIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVGKQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALNESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYGGVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQAAIEAANDLYGEGSKQSASVEKAYEAVGIL
The following text describes a protein:
Function:
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
Sequence:
MDIIKFDVYRGPNIGVYISVNDNTILLPMGFAKTKAEKLAKYLGVNYLFTSIANTRLIGALCIMNNKGILLPKTAYQNEFDFLKKELDLEVGVLDSKLTALGNVICANDKGAVVSPWLSKEDCQTISDVLGVETIQKKIAGFNQTGVVMVANNSGAAIHPEADEEDMKTFSNLLGVKIEQSSINNGIPYVSSGILANNNCIIVGSLTTGPEIMMLTRAFLN