lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Sequence:
MLEIGKYGNMFTEEQNELVVSAAEMLYGLIHVRYILTTRGMSAMYKNYDFGRCPRVYYFGQPCLPVGQSNIPRSSSVKIYCPKCEDIYYPRSKYQGIWLHNRYGWCLFWNDFPSLVPDDLWSPEATKGHTMLHPIGNYPSPYKGSQRREVDDMAHGAALALTKASQRGGSPHLDTVRTKRHGNLIDEEIFEGSSRSGGAKNEGYQKGRKFYGQKDDNDLDDGGEACSGTGEGLAVGVGGKFDENIEYYSQGKRKKNKKLLFRDETSALDALQTLADLSLMIQSSKDSPVLKDDKLATGTNDNNAPGRPGSTSNRRHKTKVSVEKEKVGNEFPRGESSKSRREVKVDYKALSEGKQKRKNKSTSFEVFIEEEKPTDKLLHSTQCYT
The following text describes a protein:
Function:
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Sequence:
MGELLGSGSFLHLGDIVSLFAEGSVSAFLSTLGLVDDRCVVNPEAGDLTNPPKKFRDCLFKICPMNRYSSQKQFWKAAKQSSAGGGSGDASLLKRLHHAAEIEKKQNETENKKVMGSLVRYGSVVQLLHLKSNKFLTVNKRLPALLEKNAMRVSLDPSGNEGSWFYILPFYKLRSTGDTVVLGDKVILNPVNGGSQVLHVAANHELPDNPGCKEVNVVNSTTPWKISLFMEHRENLDDVLKGGDVVRLFHAEQEKFLTMDEHKKKQHVFLRTTGRVSATSATSSKALWEVEVVQHDPCRGGAGHWNSLFRFKHLATGQYLAAEVDDDTAVDGMRSKLRDSNNGPVYHLVPVPHANEIASIFELDPTTLTRADSLVPQSSFVRLRHLCTNTWVHSTAIPIDKDEEKPVMSKVGSAIIKEDKEAFALVPVPAIEVRDLDFANDACKVLVGVSARLEKGTISQNERRSVTSLLQDIIYFIANGEADQNKSDALELQVTVTNRDRQKLLREQSILKQLFKILQTPFLEPSKDGEGPWLRLDELQDPKNAPYKYIFRLCYRIFRLSFQDYRKNQEYIAKHFGFMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMRQWEWRFLDYLSDLCLSNKVAIPVTQELICKSVLSPENADILLDTRMLLTPQEMEMDPDSFNYEDDDVILIWGRHQTTRKLADLALRARGGGVEEQAILDYYRHQLDLFSNMCLDRQYLAINRLSEHLGIDLILKSMADEALPYELRASFCRLLLHMHVDRDPQEPVTPVKYARLWSEIPKQLSIEDYDNKLPEHENKEAVHQKFSSTMIFVEDYLCNLVHKAWSLQCKDQNKLTFEVVKLARELIYFGFYSFSDLLRLTRTLLNILDSANNQELEAPDGGGVLRSLSDMGAVMTSLALGTAGFAKSPMPLSLRKKQAQAALKKEDPLVMDTKLKIIEILQFIMNMRLDYRISCLLSIFRREFDESSPSGGASGNDTPKLLEKRIDLESISLKAESIFDNHHTKIIGDLDGQGGKTFLRVLLLLTMHDSPPLVSGALRLLFRHFSQRHEVLQAFKQVQLLVSDSDVESYKQIKADLDGLRLLVEKSELWHHPASPIASQQETCGQRADAQLLRQTRPVLSTTSSVGSGGGSGSGGSEDVRMNELMRLAHEFLQNFCRGNQPNQTLLHKHLELFLTPGLLEAQTVCAIFQDNAQLCSELSDKVVQHFVHCIETHGRHVEYLHFLQTIVKAEGQFIRKCQDMVMQELVNVGEDVLVFYNDKASFNAFVDMMRAERHRLDATDSSGALKYHIELVRLLALCTMGKNVYTEIKCHSLLTLDDIVAMVSHKDCIPEVKEVYINFLNHCYIDTEVEVKEIYTSSHMWSLFERSFLVDMARCASATHDRKHADTALEHYVTSSAVSVVTTFFRSPFSDQSTAVQTRQPVFVQLLQIAFRLSQCAWLSSSQRHSVESCIRTLSDMARSRSIAIPSDLDNQVTSLFNKPALHLGASKASKIFRSSRLQSAHLSRESSQSQLSVRFDRTIIEGLQDIVVLLEAQLHPLVQAESSVIVDVLYRPEYLFQPGTEARKKCDNGGFIRRLIKHTERLLEDKEEKLCIQVLNTLRQMMNFDVHNGEKGDALRKNLLVRYFSKSASHSSKKTELNGGSGISTAGIHSTLSGGTGGVGGGEMCLHEVQVYLDREGASDLVAELVMKSSWASPCWKAATPSSSEVSTRNCSRPRRAPSSSRCSTTKSESRKRKSGPPCRSTRPGETTTTTQIANCTATDSDMESKLSAKVLVMLPVFRFLQLLCENHNRDQQNFLRAQSNKNSYNLVSETLMFLDCICGSTTGELGLLGLYINEHNVALINQTLQTLTEYCQGPCHENQNCIATHESNGLDIITALLLTDINPLGQRRMDLVLELKNNASKLLLAVMESRGDSENAERILYNMNPRQLVDVACKAYHQKLVGGEEAASPKEVVGATQQRIGRPDEPPPVDGVSGDAALQYYANHTAQIEIVRHDRTMEQIVFPIPEMCEYLTNDTKVRVFHSAERDDQGSKVAAFFEGVDLFDEMKWQKKLRGQPFLFWVSSHMSIWSQILFNLAVIINLIVAFFYPFDTDGPAPDPGTHLSGLIWAVMLLSAAVAITLPKPSGIRTLVMTVILRLICSAGPQPTLMLLGTATVVLKGVHLLSIMGNAGTFQRSVRQICTDTEIVYHVVYLIFCFLGLSTHPFFFSVLLFDVVYREETLLNVIRSVTRNGRSIVLTAVLALILVYMFSIIGYFSFICSGGSTNSFMSQIEEAEGSGGGGGESRERACDSLIMCIVTTLNQGLRNGGGIGDILRAPSSREPMFGARVIYDMLFFFVVIIIVLNLIFGVIIDTFADLRSEKQQKEEILKNTCFTCGLDRSQFDNKAVSFEDHILHEHNMWHYLYFIVLVRVKDPTEFTGPESYVYAMVKDKNLEWFPRLRAISLAAEGEESEQNEIRSLQMTEHRKQKQRMGLLNSAPAYFHHLSQ
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSLYRSEEMCLAQIFLQSEAAYSCVAELGELGLVQFRDLNPDVNAFQRKFVSEVRRCDEMERRLRFFEKEVTSSGISILNTGENPNAPAPREMIDLEACFEKLENELKEVNTNQEALMRNFLELTELKHILQNTQTFFSEGNRPDEAFGFSDMQLGFVTGVIRRERIPAFEQMLWRVCRGNVFLRQAEIEEPLKDPSTGEEVWKSVFIIFFQGDQLKIRVKKICEGFRATLYPCNETAAERAETSMAVLTRLEDLQKVLSQTEEHRQRLLSLASKSLRVWFIKVRKLKAIYHTLNLFNLDVTQKCLIAECWCPVSDLDQINLALRRGTEVSGSSVPSILNRITTDEEPPTYNKTNKFTKVYQSLVDSYGVANYREVNPAPFTIITYPFLFSVMYGDMGHGLIMFLFGLWLVVREKQLHASLANHEMFGMLYGGRYVIMLMGLFSVYSGFLYNDCLSNSVNIFGSTWNATNMNYTDELLSQDISLGLDPKYSATGAVYPIGIDPMWQLSTNSINFLNSYKMKLSVILGVSQMTFGVFLSFCNHRYFKRSLNIWGEFVPQLIFMISIFGYLVVLIFVKWLIYDVWNENSAPSLILTLINMGLLTPPDPPMFPGQPSLQIFLVLLAVSCIPWMLFVKPVVLYLRHQNRPLSTYLTWPNRGTADASGLLSSDTQAVINQDELAINNSDAEDPETSNHLEQPASLVPKEFDFGETFIYQAIHTIEYCLGCISHTASYLRLWALSLAHSELSEVLWNMLLAIGLRMNGFVGSIATFGCFGAWAILTVGILLFMEGLSAFLHTLRLHWIEFQSKFYKGEGHPFLPFTFDAILEGKEE
The following text describes a protein:
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MPIKSSILILFLATSSQSQDEVVITFFPSSGFLIRNEPFLLSCTVINAKSIRFRCNGEWMDESRQLSMEGVNKDGTLYLQSSINISKSEDDIEKRCDCYGIGKGEITVKSERQAVISPAYMKKHFEHNPPSSIRIKEGSQFALPCLPPLSHPVPIIEWTRNGQVISLDNYRIMGSDGSLLFSSIRLQDGGAYVCTATNVAASRSTPPSSIYVYVDGGWSEWTEWNGQCSVQCHQLDRMIKLRGHQVIPTLSRRRWCNNPAPLNGGLPCTGDDEESSLCPLLCSIDGGWSEWGKWSLCSSQCTTNRTRTCSNPYPLNGGNHCIGDSDDSISCSTGICSSRWYVSDGIVVVSLFAVPILLSILLSLCILLLCRQKSIRTHSYCGDIASYKSGIIVEGAPFMHSPLPSMTMMTNKNGYARYESGGGYSISRGGESRQALLDGCSTTSSARKAFLTTNSSVTQEDTYATVYECVRGDIYEGEGVLPARVDREGGRLSIHNNGTHLLIGEESLESPTTIILSTHSPDDDLPMKDEYEIPVSCAISTNCSSQSCIPRFPFILSFTHCMQSIDEWNIYLYSNTNYGWDRYEIESDSNDSTSPIFTHFDSHNSSIIHCAIPHYGKFLLCARPKKLNPMLRMRVAVFTQIDRRDTFSLRVNIVRDGSGKTDRQENERLIIESIMLVVMDGGPLCICLEDIAPSFSSTHNYMEMDLSTQSSYSFEIESIDTERTFNARLVLLQKGSFFSNPLILSVSLDHNYDELVTTEESQVSLDFRLPYAVKERIVSLLDPPSERDWMSLARCLGISSFVHFGRTLSSPTTVLLTLWEARREDPCHLAHALRLSGRPQIAHIVDNIR
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Promotes organ development by modulating cell division rate. Prevents abscisic acid (ABA) signaling leading to stomatal closure and seedling growth inhibition. Involved in oxidative stress signaling. Prevents anthocyanin accumulation. Accelerator of defense gene induction required for rapid defense gene induction, and for the establishment of both basal and effector-triggered immunity (ETI), in a NPR1-independent manner, but is not required for systemic acquired resistance (SAR) establishment.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: No experimental confirmation available.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Folds into a two seven-bladed beta-propeller structure which is required for elongator complex assembly.
Sequence:
MSENTKVEAKRVFIGAGCNRVVNNVSWGASGLVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPTSKFAFKAKKLDRQYLLSGDSDGIIILWELSTLNNDWRHVLQLPLSHKKGVTCITAYMVSETDAMFASASSDGVVNVWDVSFPSQPSEECKVVCLDSICVDTKAIVTLSLAELPQNPGRFALALGGLDNKIKLYSGERTGKFTSVCELKGHTDWIRSLDFSLPLHTTEEIPNSIMLVSSSQDKVIRIWKLVLVGDVGSWRREITLASYIEGPVFVSGTFTYQISVESVLIGHEDWVYSVEWQPPVIDFIDGRLVNHQPLSILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSSSKESENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAWKNDEGNEAEDEHWHELARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPLSFLKTLNHTCAGGEGSFPEDLQADVQVLGANMSALGLSQKPIYLHSSSEPLERNGGGEGLDTFETVPEAAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTDNGEVSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKQILVLPPFGSSVTAVAWTGLDRNEKSGCVAVGMESGLIELSNVKIIETEEGTTATAALALRLEPFMCHVSAVNRLAWRPTEKCESNQSLRWLTSCGDDNCVRVFNFKF
The following text describes a protein:
Function:
A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response (By similarity).
Subcellular Localization:
Secreted. Note=Secreted from the fat body into the hemolymph.
Sequence:
MNSSTALMCFALLLISPLCLGYSDEDREADSRRIAEIIQNAQDDDSKINSTQELLDIYRRLYPTLSLEDRENIDKFVNEHTDAIVIDGVPIQGGRKAKIIGKIVSPAAKGLAVGFFEELGSKIAQLFTG
The following text describes a protein:
Function:
Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa.
Subcellular Localization:
Secreted.
Sequence:
MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVHITSLLPTPEDNLEIVLHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNFLFLCLQDTTTPIQSMMCQYLARVLVEDDEIMQGFIRAFRPLPRHLWYLLDLKQMEEPCRF
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Late endosome membrane. Membrane; Multi-pass membrane protein.
Sequence:
MGKKTQPYPQPASSQQQLHYHQPPPARVRRAPHGITVSICVKYTIFAFNVIFWLCGLGILAFGVWGLVSKSVSSVEAIAEEVGIKLDPMYGFIIVGGCIFILAFLGCIGSLRENTCLLKLYVIILVLIFLAEITIGLLVYFYQDRFVTLLDTWVEKTLLNYFDDPDSQFLMDNMQEGLTCCGVNSPDDWQKNAYFNCSSIADSRCSVPFSCCVPDPTTSVINYQCGYGVLALPPTEWFMTIYTIGCAQSLTDWFKTNVILLSCIGGALVLMQSIAICLARSLIGDVKEVKSYW
The following text describes a protein:
Function:
Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila. Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors. Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial peptide synthesis, reduced mating receptivity, reduced day-time sleep and reduced lifespan in multiple mated females.
Subcellular Localization:
Secreted.
Sequence:
MKTLALFLVLVCVLGLVQSWEWPWNRKPTKFPIPSPNPRDKWCRLNLGPAWGGRC
The following text describes a protein:
Function:
Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Note=Binds to chromatin from the end of mitosis until prophase.
Sequence:
MSTTNTAAASQDACYISLLGLAEYFRTSQPPNVKKCIQCLQALFTFTPPSKVEARTHLQMGQILMAYTKNIDMARQHLEKAWNIAEPLMNFDDVKFDTASVLAQLHLQTDQSSHTAKAMLRRAVELSQHNVYWHCKLLLQLSQIHASDREYSLASELLAVGAESAEEAGATYLKVLFLLSRAMILMIERKTNDVLALLNTAGQIIDNNIPNPHQKEYLKVFFLVLQVCYYLALGQVKTVKPSLKQLQMSIQTIMAPNWPTDEAIFGANQLEMFVWLPKEQLYVLVYLVTVSHSMMAGYMDKAQKYTEKALTQIEKLKMQEDKPILSVFKVILLEHIVMCRMVMGNRELAIREIAAARDVCLAVPHRSLLKRHSAQLHCLIGLYSMSTSFFEHAERQFLVCVNETTERDLKLFANLNLAIIYLRTKRDADLKQILDAVSTENTHTYSSQALMGGFYYVQGLHAFHKNSFHEAKRFLRETLKMANAEDLNRLTSCSLVLLSHVFLSIGNSKESMNMVTPAMQLASKIPDIHVQLWGSAILKDLHRMSKDAQHEKDAYANHVKYSENLIADQRKCVQSAHHELVNWFQGDPPVTSGAAALILSEIPTTSALQPTTGQQFGQFY
The following text describes a protein:
Function:
Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAGAPAPPPPPPPPALGGSAPKPAKSVMQGRDALLGDIRKGMKLKKAETNDRSAPIVGGGVVSSASGSSGTVSSKGPSMSAPPIPGMGAPQLGDILAGGIPKLKHINNNASTKPSPSASAPPIPGAVPSVAAPPIPNAPLSPAPAVPSIPSSSAPPIPDIPSSAAPPIPIVPSSPAPPLPLSGASAPKVPQNRPHMPSVRPAHRSHQRKSSNISLPSVSAPPLPSASLPTHVSNPPQAPPPPPTPTIGLDSKNIKPTDNAVSPPSSEVPAGGLPFLAEINARRSERGAVEGVSSTKIQTENHKSPSQPPLPSSAPPIPTSHAPPLPPTAPPPPSLPNVTSAPKKATSAPAPPPPPLPAAMSSASTNSVKATPVPPTLAPPLPNTTSVPPNKASSMPAPPPPPPPPPGAFSTSSALSASSIPLAPLPPPPPPSVATSVPSAPPPPPTLTTNKPSASSKQSKISSSSSSSAVTPGGPLPFLAEIQKKRDDRFVVGGDTGYTTQDKQEDVIGSSKDDNVRPSPISPSINPPKQSSQNGMSFLDEIESKLHKQTSSNAFNAPPPHTDAMAPPLPPSAPPPPITSLPTPTASGDDHTNDKSETVLGMKKAKAPALPGHVPPPPVPPVLSDDSKNNVPAASLLHDVLPSSNLEKPPSPPVAAAPPLPTFSAPSLPQQSVSTSIPSPPPVAPTLSVRTETESISKNPTKSPPPPPSPSTMDTGTSNSPSKNLKQRLFSTGGSTLQHKHNTHTNQPDVDVGRYTIGGSNSIVGAKSGNERIVIDDSRFKWTNVSQMPKPRPFQNKTKLYPSGKGSSVPLDLTLFT
The following text describes a protein:
Function:
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDTLRLRPGCPVALPLLAGSVALLLLLGPAGAQCPAQCSCSRAAQVECSGPSISEMPLPLPGDTMSLQVVNTQVAELGEAAFGNASALIAVRMEKNGLWRLSPGAFLHLSSLRYLSLASNRIRELPLEAFQSLGRLESLLLSGNQLQRLHPAHFTQLAHLKELQLQGNQLQAVHPGAFDQLTSLARLNLGKNRLARLPPRLFAQLHRLQVLRLYENQLAEVPPRAFEALAELQELGLHQNRLRQLPPGLFAHNRKLQKLFLSHNRIEALPEGLLLDLPELSQLSLFGNALRELPRGTFGPMPGLRELWLYDNQLTALTDHALANLTQLQLLVLSRNRLRSVAPSALAGLGSLLEVSLHTNQLTSLDTETFRGLDKLQNVSLQNNRIESLPGGLFHHNPSLMTVQLQNNSLQTLPGGLFDRLPHLHEVKLHDNPWRCDGEISGLHAWMRRNRALLGGSPPLCASPSQLEGQPIWEALFGPEVTEVIDITDVTEVTEGWTPTPGQTDSPSWEGRPETTVAPIHLHPGPSEAEGGIWGLTRTQTGVVVTCIVVGCALLLGSLAAMAYYSYQRKDSGHAKV
The following text describes a protein:
Function:
Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics.
Subcellular Localization:
Cell membrane.
Sequence:
MEGLEGCSGDVIHLNVGGKRFSTSRRTLTWASESFFSSLLSGRIPTLKDETGAIFIDRDPTVFGPILNFLRTKELDNRGVKSSVLLHEAEFYGITPLVRRLQLCEELERSSCGSVLFNGYLHAPIFPAKRRNRHSVSGLQVNSRSGFNERAPVRRSNTMPPNLGGAGLLGRLIEDRCFGNGAVFPSDPGMVRIICGHHNWIAVAYAQFIVCYRMKETSGWQLVFTSPCLDWVIERVALNAKAMVGTLGDNDKMLAVSSCSEIILWAISGDSSGSEIGVFSLGVPVEALFFVGNQLIATSHTGKIGVWNAVTKHWQIQDVVPINSYDTAGSFLLLGCNNGSIYYVDVQKFPLRMKDNDLLVTELYRDPSEDAITALSVYLTPKTSDSGNWIEIAYGTSSGVVRVIVQHPETVGSGPQLFQTFTVHRSSVTKIMLSERHLISVCADNNHVRTWTVTRFRGMISTQPGSTPLASFKILSLEDVDGHAGSSAGNDIGPFGERDDQQVFIQRVVPDSNIVYVRLSSTGKRICEIRSVDCTPITSFTVHECEGSSRIGSRPRRYLFTGHASGCIQMWDLTTAMEVASKGESRELGGLTEKELLEQLEQCDLALTRTPELSPAASFSHSANPRASITSLQSQPSERFSRTAFPSSRPPVLNGRPSEGWASLCSLQPNLSGSFGSLQKSDTLPRSGSRPCRALRNQPQMEVNGMASTDSTSARASGSFVERCQELARYTESQYLGSQRSSYETVATRIKTPRGSTSARRPGSPTPPQPPPLGIATSLAPCLPPTCFSAVGEASASSPTAPKLTLKPRLNETSF
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MQIGIYGSGTTSNAAKIVKKILDDAGIKSFTITKSKSKPADCVIVLGGDKGVRNYFHRTFDSTLPILGISEGETSGFLAQIDLKEFASYVDILKKQKYTIEEVPRLGVKIDGKNVYPVLNDVAVFSSRSAMLMEHTLRVNGEEVWHDNSDGIIVSTPIGSSAYSMSAGGPVLFQDSAVFEIISVNSLDVTRRPIIVSNDSSIEIDDISARLHCEVVLDGLDRYKVNKTVECTQFFPPAKIIRLKKDSTAISALAKKVHLAEELLSMPPSSKLLLKTLEYEGALTQKDLANKTLLPDRTVRLALSHLLKKGYVKKKVSIRDARQKIYEISKIE
The following text describes a protein:
Function:
[Protein hedgehog N-product]: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development; [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
Subcellular Localization:
[Sonic hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane; [Protein hedgehog N-product]: Cell membrane; Lipid-anchor.
Sequence:
MESVADDHYDNGHYRHNILSKVLKIFSNNFLRQLKRHTQDLYKRHQKQQQQQHKHPTSQQQQQHVDQQQTDDKHHQWHGQHQKQQPLKLQTQKYQDIHQQQPQNQQQQHHQQQQQHLLHHLSTSLSLHLSDISDSYSNAFNTSITDSSKSSPDHSTNHYNHYHDSISTHHHRHHYQKSQRQRSLLTRPPFYAVLIFFLVVFDGRCFVGSCGPGRSYFSPRKGPRKMTPFVLKQHVPNLSETTLGASGQPEGKVSRGDPEFKKLVTNKNPNIIFQNSEGTGADRVMSKRCSDKLNNLASLTMEQWPGVRLRVVEAWDEDETHPEDSLHYEGRAVDVTTSDKDKSKYGMLARLAVEAGFDWVHYEYRSHIHCSVKSDSLIAEHAGGCFPPEATLYRPDWSAVSMRDLQIGDLVWTFDGDVIKTPPPFLSLRWTPPWLLKLLQWPLSLLSSSSPSRSSSSFSHSLSSSSSSSSSSSLSAGRLVLTEVIAFLHKDPNLEMEFVEVKVGNNLDNNDDGNDNNDDSFDGYDNHYHHLHSRQQQQKQPQQQQQQQQQQQQQQQHHHLITLTDNHLIFLNRHHHHHYQHHHHFKMKKKPNDDDSRHISDESDKNDGVSVDNDDYNSDKSNIITSFAAYLNTANDFLFIVTPPPSSSPTPTQPPPSSSTPPSTSSSSTSSHHLTSSTDTIVEPTKIVGISKTRHRGIYAPLTTHGTMLVNGIWVSCYATYNNHHLAHMSLAPLRWWLSVAGVVKGAVGTALEVVGGFAGWVQWWISGKSGFYHARQNYGVYRDDDDNINKNINIGDNNVNNNNNDDSIKEFNVIGSIDDDENNSINNNINNDNKINCSSLLKLNNNNNYYYKNNIHNNNNNNNSNNNNNNNNNSNNNISKFLVNVYSAHSGCACDLNYTATNNNNNNYNNYNNNNNNNKNINNNNNNRIINDNLSDNANAVSHVSHCHYNNKFYDKTCDSIDSEKFDNNNNINNNNNNNENNNNDNRYYFCRDKNSYFICKDNNNNDNNNNDNNNIIDNNINNNNNNNNDNNNNDNNNDVNRETSADQNYMHPYIKILWKIAKIIRPECSFFTN
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MAPARLSNSLFGTFRAASHRPLAAVCRQRCSYHSYDYAEVPPFSKAESAILSSAYAHVPGYGFTIDSLKLGARDAGYLDVSTNLFPRGVFDLINYHLVTQRLALKDNVQVPDNGEKKLGVGSKALAIMAQPSYVPASISELAKLADEIWFLAGDQSVDSSWYTKRASLSTIYSATEVYMTQDKSPNFTETEQFLDNRLADLMKVGGFMGALGEWVNYTGHSTVNVLRSKGFEFDTSSGARKYALVDTNSSVFAMRAAFFCFSSTKNSFMVSFGYKFLTIACKRLKGVSGT
The following text describes a protein:
Function:
Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. Required to localize MPC54 to all four spindle pole bodies, and localize DON1 and SPO14 to four prospore membranes.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Nuclear in mononucleate meiotic cells. May not be localized to the spindle pole body or prospore membrane.
Sequence:
MNQGYTQLSAPELKETKTSKLNKMNNFRSSPIAEIINKIPPDCGKIQNTTFPEFNPALRRRQHEQWPAYEKPIRVTDSMSPQLSSINCLPNLYPHGTLPLPNPYLSYLNHIEKVNCQDVKFSNWSVLHNSNNGFEIPTYFSPRTTQNMPCSEKVESWLERLPIFVGFDGYLFTNCFDYEYMLDWEETEFTFEKTSCMETDYSKALTDTDIIYIQEKKIEALIRNQYLKEYEFSQKDF
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MANHHDHDKPLRSALDPISSPYFSSLNGTLSIAKEVLIGPFQGDHRRSESARILSDLAPSLMQPRFLNAASSSQQSLSKSSHPGAPYPLLRLPTNLPFNKSSRPTASSLAILEAVDNLASLSLGDVSHPQNGQNSPSLIRGFKATIPSSELAKQRRRMVRGGIVDEDLGGKIGLKKLGDRARGLLTEKGEDEEDGELGVGRHAVKKRRKKRESRRFTEGRHLEGKLRLEDLAKQADEIGQDKENLHVRQSLIQSEIAEVGAKIDALEDIRRHLEASLLHLQEEDLELDDELEGVQELMASPAIKAAAGAKSLPLSSSGAGISNKSSRRRKGPAFLPSEHDELPSGVAFMTLNGHTAPITALDFDEPYGMLVTAGQDDVVKVWDLCDGEEIGQLRGHRGTVKALQVEDTLCLTGGADGNVRLWDLRMVEDYEERLHTQLAELARQDPLERIAEQRAHEEDGEHAEQDDELPDGTLQDPQPGDGSPCVRTLEGHSKSVTSLYYEDGCLVTGSSDKTIRQWDVATGQCVLTMDILWAISNPPPPPSSVPPQRPPRLSHRSSTSFGSNTYEDILPSPGASLVGMSGAALLGAATGQNFAVPTPPYADGTWEMYQDFVGGVQFWGYALASGSGDGGVRMWDMRTGQAHRTLIGHTAPVTCLQFDEQYIVTGSLDRTVRIWDLRMGSVSEVHKYEYPVTALQFDSRKVVACTGENGVEVYNRTTHAHSRLVVNGHTKPAEKMRFIDKYLVSGGRDGCAKVWAM
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MVQSLLSLSQSIVRSGVPKRKPTVGRPQASRRQASLIPAVRRARHHCLSTSPPLIVNLCRSSGYPDNPKAAGPGQPSGSIRAFSLTSASTIRPPQERPAAHSAIPESISKTTGYQLDHLGLLVQFDKDRSSKFDHIWLRDNCRCEKCFHAHTKQRLLDTYEIPLDIQPTRVDLEGEGFSLTWPDGHKSLIQLSFLLQHAYDPPLAPSSASSSTQTPSSEKYLWDKAIANRLPSVSFNDLFSQDQATWKGDLYVLEWLRKIEKYGFCLVDDVPPTPEATADLLKRIAFIRETHYGTLWDFTADLQHGDTAYTDLALGAHTDTTYFSDPIGLQLFHLLSPPSSHEGGKSLLVDGFAAAAKLKLECREAYELLSEEPIETHASGGVDVAFRPLLPQPVFSHHPHTGELTIIRWNPDDRLPLNPRSAGRVKQLYLAFREWQKIIKSEQMELWTQMKMGQALIFDNHRVLHGRSSFKGSRRLCGGYVNGDDYRSRLRSLEQRLLSRSPGSTNHQA
The following text describes a protein:
Function:
Member of the two-component regulatory system SsrA/SsrB (SpiR/SsrB) that is required for intracellular proliferation and systemic dissemination within the host. When inside acidic Salmonella-containing vesicles (SCV) within host cells the SsrA sensor kinase autophosphorylates and the phosphoryl group is transferred to the response regulator SsrB; phosphorylated SsrB activates the expression of genes encoding virulence proteins, including pathogenicity island 2 (SPI2) and other horizontally acquired genes, and antagonizes the action of transcriptional repressor hns (H-NS).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNLLNLKNTLQTSLVIRLTFLFLLTTIIIWLLSVLTAAYISMVQKRQHIIEDLSVLSEMNIVLSNQRFEEAERDAKNLMYQCSLATEIHHNDIFPEVSRHLSVGPSNCTPTLNGEKHRLFLQSSDIDENSFRRDSFILNHKNEISLLSTDNPSDYSTLQPLTRKSFPLYPTHAGFYWSEPEYINGKGWHASVAVADQQGVFFEVTVKLPDLITKSHLPLDDSIRVWLDQNNHLLPFSYIPQKIRTQLENVTLHDGWQQIPGFLILRTTLHGPGWSLVTLYPYGNLHNRILKIILQQIPFTLTALVLMTSAFCWLLHRSLAKPLWRFVDVINKTATAPLSTRLPAQRLDELDSIAGAFNQLLDTLQVQYDNLENKVAERTQALNEAKKRAERANKRKSIHLTVISHELRTPMNGVLGAIELLQTTPLNIEQQGLADTARNCTLSLLAIINNLLDFSRIESGHFTLHMEETALLPLLDQAMQTIQGPAQSKKLSLRTFVGQHVPLYFHTDSIRLRQILVNLLGNAVKFTETGGIRLTVKRHEEQLIFLVSDSGKGIEIQQQSQIFTAFYQADTNSQGTGIGLTIASSLAKMMGGNLTLKSVPGVGTCVSLVLPLQEYQPPQPIKGTLSAPFCLHRQLACWGIRGEPPHQQNALLNAELLYFSGKLYDLAQQLILCTPNMPVINNLLPPWQLQILLVDDADINRDIIGKMLVSLGQHVTIAASSNEALTLSQQQRFDLVLIDIRMPEIDGIECVRLWHDEPNNLDPDCMFVALSASVATEDIHRCKKNGIHHYITKPVTLATLARYISIAAEYQLLRNIELQEQDPSRCSALLATDDMVINSKIFQSLDLLLADIENAVSAGEKIDQLIHTLKGCLGQIGQTELVCYVIDIENRVKMGKIIALEELTDLRQKIRMIFKNYTIT