lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ).
Subcellular Localization:
Synapse.
Sequence:
MDDDLTEYAPDIPDNVLELIFSYLKLQDLRNCALVCKSWHRFLSDENNEVWRAQCMQKLSPDAFKTDLLSVVPTYKAKLRAFFHAWNPYDCSRHVYIKPNGFTLHRNPVAQSTDGSRGKIGFQHGRHAWEVRWEGPLGTVAVVGIATKDAAIQCHGYYALLGADDQSWGWNLVDNLLLHNGDAHGIYPLLNNAPKYKVGERIRVILDCDDNTLSFEKNYEFLGVAFTDLPDKVFYPTVAAVYGNTEISMVYLGPPLDG
The following text describes a protein:
Function:
Transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. Binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA. Functions as a dimer with SPCH during stomatal initiation.
Subcellular Localization:
Nucleus.
Sequence:
MGLDGNNGGGVWLNGGGGEREENEEGSWGRNQEDGSSQFKPMLEGDWFSSNQPHPQDLQMLQNQPDFRYFGGFPFNPNDNLLLQHSIDSSSSCSPSQAFSLDPSQQNQFLSTNNNKGCLLNVPSSANPFDNAFEFGSESGFLNQIHAPISMGFGSLTQLGNRDLSSVPDFLSARSLLAPESNNNNTMLCGGFTAPLELEGFGSPANGGFVGNRAKVLKPLEVLASSGAQPTLFQKRAAMRQSSGSKMGNSESSGMRRFSDDGDMDETGIEVSGLNYESDEINESGKAAESVQIGGGGKGKKKGMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESTPPGSLPPTSSSFHPLTPTPQTLSCRVKEELCPSSLPSPKGQQARVEVRLREGRAVNIHMFCGRRPGLLLATMKALDNLGLDVQQAVISCFNGFALDVFRAEQCQEGQEILPDQIKAVLFDTAGYAGMI
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of 2,5-diketo-D-gluconate (25DKG) to 5-keto-D-gluconate (5KDG), 2-keto-D-gluconate (2KDG) to D-gluconate, and 2-keto-L-gulonate (2KLG) to L-idonate (IA).
Subcellular Localization:
Cytoplasm.
Sequence:
MTSIKNNNENKHIVVYRKIHQSLIEKLENQGYKVTQFEPINSNNIQEFYEAIKTANGLIGSVFKIDENVLSKAPFLECVSAISVGYDNYDLVVLNDRKIPLMHTPNVLNDSMADIMMGLMITVARKLAYCDKRMRNGEWNGPLDKSWFGLEVHHKKVGIIGMGRIGEVLAKRCRMGFDMEVAYYSRSRHLKVEELYDAKHQDLDTILSTSDFICVVLPGSQETKHFFSFGQFSKMKNSAIFINAGRGMTVDEVALIDALETGKIAGAGLDVFEKEPLNKDSKLLTLDNIVLLPHIGTSTIETQHIMSECAVNNLISALNGNLEKNCVNASIIKK
The following text describes a protein:
Function:
Involved in the biosynthesis of galactolipids found in the photosynthetic membranes. Catalyzes the isomerization of monoglucosyldiacylglycerol (GlcDG) to yield monogalactosyldiacylglycerol (MGDG).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAMAWLMGLGLALASVLWVELVRDCYHALAHVWSPLYRLHGWHHRVFRSDLSVVSTEIYQKAHWYNDVPEALVMLAFGIWPPLLTWMWQGFSQWPLILAASAGMVYTLGFLLSAIARGVGLPNADEITDLTHRPGPFLTPPAPWMVNRTYHWRHHFDDPNAYFCGTLTLVDKMLGTALSLKGKKIAVTGASGGFGQALLQELHQQGAKAIAITSCGQEVTVIGAEKTIPIRTEQWCIGQEDQLKDLLAEIDVLVINHGVNVHQRRDGQAIQEAYEVNTFSALRLMELFLATVKTNRHIATKEIWVNTSEAEVNPAFSPLYELSKRALGDVVTLKRLDSPCVIRKLILGPFKSKLNPVGIMSAAWVARQVVKGVKRDSRNIIVTINPITFIAFPVKEFFVSLYFRCFTKKS
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLIVTGADRYSPDKLPQLEAYVDEQVANRSWSLDANVTLLRFYQFSPASVKPAIVAKVLIKAIMQAPAQDYKCCITLLPERLLQSDESVYKVVQLANALETSRFGDFWNAANTCRDLLGGIPGFYESVRGFIAHTLVHTYGRVTKRTLADCLKLEGATLEQYLSEKCKSAGWSIVNTPAGEVVGLPKNDDNQSVVKRTQELIRFDQVAPMLKAVTVGF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MKKVERWKISGIEFDVLRSHDILKLSVVENDSIAGLIERPKDLYDARLGIPNESRRCETCQGTRRGVCDAKLSCDGHFGHIELPSAIYHPYHVRRVVKCLSKICLGCSRAFKKKIRPNPIQLDDVPDAVESQESATGKRVTRKRKFSETESEKKVPKSRKRNGIQKWLDRLDCDNDVAGVKEEDGHDVYTTKYRSWSSSVPKSTSPPLVQVKDEPMDFRIDDSYPVPPTQEKNVKDAAGRSSTKDRAHTRVTGRFHGSAQRGAKEVRREPRGEPEAYPGHSREDGSETASENSCRYCGKSSEGLGPKFPKVVLRVVTIVTRSGRVDAIQMIAEVKHRGAQIPSGFWDFVGGHPGAETENSRVLLPFEALKILRKVPVEDHARLDMDRVVTHPEAFIPFVIPVTPNCNRLIMDDWSSTLMPRIILGRGGPNSKLEALVSKVRQINSTKSSGKRTFTTERRDVEELQLLVARHLRACKVTDFSSFGKQKTTEQETGGSLELKWLKNHVLSKRSNFSARTIVNGDPNISICEIGIPYEMALSLTVQETVNSVNLRNWQKVIADIKTGRLVSPPGPLFLRTRNNLFDLREKCSSILSNYEVRAGDVFTRCLQNGDYLFANRPPSLHKHSLIALKVKLHHPLTFAINPLICAPFDADFDGDAFHVFVPQAVESIAELSELMSVSSQLVSTQGGQVLISLTQDTLVGGHFLTRYHNFFNHAEFCQLSMSCSVVMPLPAIVKSPAGPLWTGKQLYSMTLPRGFDFGTLRGDIYVKSGELLICKGSSGWLQTSVKGIVKAICDHPGPKAALKYLNSVQAMLHQWLMSRGFSVGLKDFYLAKTRESRRTMLEGIRRCLQRSEEASLRQVLKLDPTVQARILCPKPDPLQALEDVKHGGCFGLLLGENRKSLKIKDLQRSAIEKFQSTVPIIDNLIYAYIDSDNSLLAMVKSGSKGSMSRLVHQTACLGLQLYKGENLISVNKPNNKLFYYNQSLKFRREDVFDNKNEIICQPGYWESKGIITSSFLDGLNPAEFYLHTWSARGGMLREGIEEPNKIMRNLFLFMRDLYVAYDGSVRDTTAKRIIQFQYGGLKKNSKETHSEAAQMAGEPVGALAATAIAEPSYSVKLDSYHSSQLLKAGPIQLLQETLFPRRESTLTMRDRSVILRMFPEFGVQRRALRLKRGVERVPLKKFVSTLALEFSNHGGTYEKVYYDERKKASNECVKRSSPWQCRVLLNKKALRDYDLDATAVKVRLYHKFNSATSADGLPSIIFVDTIGYNSRFLPEIMDECLVFFFHECGEVPPPTGQTSNPIRLGEKNVSNRTLEGEKDKTRKISSEMITNFLIPELLSTTVKGHDEIEEVKVIWEDRDAGCRVARPCHYPPFPMNGNPDQGELVLEVHTRKPKGAGRRGSAYSIVKEAFTLFMDDIDWARSTPYSVQEIKQAFGVEAAHLSMFRRLRSATKDMGKPVREEHLFLVADALTHSGEVAGLSLAGYRDHCVQLSMSTPFTQASFQEPKKNFFQMAVRGARDNLGGALASAVWGRQIPLGSGADFKVVPNPEEERKCTTQNGVKSGSKLLAGLKGYLSSSIANRESGKITPRKQHGVMRSSVDGKLHKRKKDLDTIVKNIDIQMLDKNLMERLRLLLKSCNVGDTVDAESQKMLLQDVLIHHPRREEKFGCGVISVKVDNHPEYPSTKCFHVIRTDGSTSDFSYRKCLEAKWQNSSTQHPPT
The following text describes a protein:
Function:
May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MHKDHNTSSSAPSTRRIRHRRRSNEIPHELSKLNGTHLLINDQDKYKSMWIRAHSSLWMVGGFLFIIYLGHLYIWATVVVIQIFMARELFNLLRRAHEDRRLPGFRLLNWHFFFTAMLFVYGRIISQRLVNTVTSDKFFYRLVSGFVKYQMVICYFLYIAGFMWFILALKKKMYEYQFGQYAWTHMILIIVFTQSAFTVANIFEGIFWFLLPASLIAINDVAAYIFGFFFGKTPLIKLSPKKTWEGFIGASVATVISAFVLANILGNFQWLTCPRKDLSAGWLKCDPGPLFKAENYPLPGWISDWFPWKEISVLPVQWHAMWLGLFASIIAPFGGFFASGFKRAFKIKDFGDSIPGHGGFTDRMDCQMIMAVFAYIYHQSFVFQQDYSVEMVLDQILGSLTLEEQQILYLKLRQIFQERQLKGT
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNISDEELKKLISENAHRFMNESNRATFLPNIRPIPPYDEMQFKIMDNCIVHGVRGLVMGAGFGFFFGALFTPNSGFNPEPTTPTPIWRQVIDGFKEQGRNGVRSAKSLSVITLVYTGTECAIEKARGRTDKLNPIYAGCTTGAVFAGRAGPVAAAGGCVGFAVFGMIMDHFMSRD
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells.
Subcellular Localization:
Nucleus.
Sequence:
MEPITFTARKHPLPNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSSRKEPVTKQVRLCVSPSGLRCEPEPGRSQQWDPLICSSIFECKPQHVHKLIHNSHDPSYFACLIKEDAVHRQSICHVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSGSLGSESPRPAPPHAAPTGSQEPGRRPMRKSFSQPGLRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQGLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQIAAENIGSELPPSATRFRLDLLKNKAKRSLTESLESILSRGNKARGLQEHSSSVDLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHFPMECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPPRLNPSASSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDENNTSDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDASSRYEDYSELGELPPRSPLEPVCEDGPFGPTPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDVGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFGGLKKERREGRGTRRVPLKDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKNTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRGSASPSDLQEPECTQPEPTGD
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MTSSYLKITEGDDEEDEGESDVELEFVGSPLKRKKMNLGQGSSGRRSGGGGAAAPPCCLVESCRKNLSGCKNYYQRHKVCEVHAKAPVVFVDGLGQRFCQQCSRFHEVTEFDETKRSCRRRLAGHNERRRKSSLEPNTRAKP
The following text describes a protein:
Function:
Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization.
Sequence:
MYFFTPPQKRTLKPVVDRVLQQQQQQQQQQQQQSLPKFQPFEVETYSLEDEKYLYNISYFSKEEIKLLYDLFHRINLDLDGFTENIIYQTLSFLVHIPSGIEELSSLFYNEDVIYRKEINSSHRSNQSFNHSNSTTPLNTTNNNIKKPTTTTTTNSNNINNNGNVNGNNTTNLDDILNNHNDNYSSDNSYLHNIYDDIYEDEDDEDDEDDDDDEDEDDEGKEFEQDDEDESTISSMSLKNSQAKRLSKKMNSIDLNVDEISSTHNQNHQNHQNHQNHHHHTTTHMIEKKITTTINKIKQKISNESSGLLCEVVGAGGAGTEGASSSTTTTTTLSNDLQTNESIKFVEDEKQQLKQQLRKQLLKDGNHNSLNNILYDYKHPNDINTPIEELTAAATTTTTTTSTTTTTNDHQNLEKTIISNKTIKKLEGVETIKDTVELEKQQQKQQQTSNVTTAKVKDTILSSSPKTTTTATTNNNNNNNNNNNNNNNNNNNNNSYKYNSYLESSNISNISNASYTDKPMDDEYYYGEYDDEDDSKPPSQEKIESINLYRSQFSIIRDCNLWGGKTLKEDEFDYIDSSSEILKYRMIIKYMVENLFSYIRKRYNLEANKNPSIIHLIEIISIMTRGTLKEKSELVFKLVRKKSEGVVYKTELLEMIQGIDALTVLNVFGLGSIGTPDEVVNNIYREGLSTVNSIQRTPSFPRSDSFYQKSMSSEQPFFKDTSLEMKEFIKRSVSNSDIPRCFGFFDLIYLCYIKPIEDYLKSSIKYKQASGYLYYEKYLGIIKAYSLRWFEVRSGFLIGYKRLFSKPSKVICLFKTNVKIIPKEHPKHHMKLKSLFKGSLSKQIDGNKEATDFVLRRFDDTEQTFISLSSHRASNFVNAIRENSKGSYRYHSFASPQEDINVVPYINGSTYFKGVYKALKHATSEIYIAGWWISPNVSLNRTATSKTPDKYRLDSVLMKKASEGVKIYILIWDETMIAMDLGSRGVKSFFEKMHRRNIKVIRHPHMLPLYWSHHQKVVVVDQRIAFIGGLDLCFGRYDNEYYFVKDNLEINFPGADYINSCIAKPVNNLKDCLVDRNTQPRMPWHDVSISLDGKAARDVTYNFIQRWNHAKDSNRDYKSYPYLITSLETPLNIPHPQPPTQFLHPNTNINNNNNNANNNTNNINNNNNNNNINNLNSSTNTTNNTNNTTTTTNNNNLNTSTNMLPINNNNNNLNTSTNILPNNNNNNNNNNNNNNNNNNNNNNNNNNINNNNTTSTTTTTTTNNNLNSSSNNLNFNISGEIHNNSLPHQLNNQQQQQHHHHHHHHYQPPLPPQQRGTCKVQIVRSVCGWSAGQVLENSIYKAYLNLINLSQHFIYIQNQFFISSVGFTQPNNQIAFAIYKRIEKAVLLNQVFRVILLLPVHCEGDIYDVDTQLIIKYTEKSITGIKTELLKKFPEMDIDQYLSINSLRNWDANGDIIFTEQIYVHSKVLIVDDKIAIIGSANINDRSLNGSRDSEICAIIEDRDLVDSRVNGLPYKAAKFAHNLRCNLWEYHLGLISNPDPLLSDRIKDLVIDSTYHDIWRNMAQRNSAIYKEIFGTTIPENCTKTSQYNRGSIKLTSEALETLCGINGFLIEYNTSMLSELETPTSIYSDIITSMKLFL
The following text describes a protein:
Function:
Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus.
Sequence:
MPYVDRQNRICGFLDIEEMENSGKFLRRYFILDTMDSSLMWFMDNPQNLPEGTSNVGSIKLTYISKVSDATKLRPKAEFCFVINAGMRKFYLQANDKQDLVEWVSELNKATKITVPKSGEQVAPNTAEACVDTSSSATKQVSYKTEIVAGVPIITTTQEKGEGQNGADKSGLRKPPGQLPYYLSRSNQDQSVIKTGYCVKQGAVMKNWKRRYFMLDDNALSYFKTDMEREPLKVILLKEVNKVQECKQSDLMMRDNLFELVTTTRTFYIQSDSPEEMHGWIKAISGAIVAQRGPGRSAASEPAEPTSTFYHDEPSLPTSRSPVPAELSFPECHLPSGHQHGVGGSRANQHAGRGTSAPVAPGVAPNLLKVNTDDCSPWQRRTNITPPSNSPKDKDLHTTEV
The following text describes a protein:
Function:
Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
Subcellular Localization:
Secreted.
Sequence:
MDTKGILLVAVLTALLCLQSGDTLGASWHRPDKCCLGYQKRPLPQVLLSSWYPTSQLCSKPGVIFLTKRGRQVCADKSKDWVKKLMQQLPVTAR
The following text describes a protein:
Function:
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MFLPQINATRLLAKSVFWAPFQQLEMARRTFRCKDLLIKLYSTNAASNTSDPLTQQTTKTLTWPEFFKLRKRRRRIESLTSIPTALAGLGLGGAFFFTRSFDATATWMGADLAVWYVLGDLVCGGVGWLLGPALGRRVWSAMHRELAAQMLEKERLFFHHVQKSRAIPLKDSYSNPIPDYYGEKISSLHDYRRWLRDQKAFIQKASWGTRRN
The following text describes a protein:
Function:
Regulates the transition between growth and differentiation.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MNYILYILLILIIFSINNTFSIGSFVYTPDGYYNLYRINKFENFSKIPTKANSVNVEPHELYYPDICDSALKNKNSNEFSIDNFPGSPFLKANIKITKGSNMTLDPLLSIHPSYINILCIEGSFTAGSQQTLTLGGIIVLPGGNFHCNNCVLQFVDLSSTIIKIDPFGFLPGILSLGGSISLIGSQRILYSAKPIEDNVLEVNDISTLDPFNGFNVSIVSDSFPNVRTSRFTYNKNKLEMQDLTIPTTDLNIKLFFNDSGSLKFGGISTRTKSSIYITGDTKLHIENYLLDSIGKTSNKEYDDTKLTFSSDNPNNVTDIIIGKNQRFRNSLYIEFSNSVTIKNSVIIGNTGSSRSSLVFFQSNVNISGNLIVGTAGSSMIAQYGTEYIESSNNYFSLVLPNEFPTSPAFMDYGHEGNGIYSLSPNIFSTNDIFNGQKILYNFNFISRENVTGFDKDCFAPCDINSIVVPSLSQEPIDFSKNLVNPISINPVDYFLIVNSDEELKNTFFTIKDSTISSKIIVNLKGSGLVLKNIIGVNNFKLTGQVKRLDIYDSFFGSSTTPSLGDNGIKSSAVIIKNSSFYIDDFQLQNNQIYGSSIVPYLYELLNVDEFILVDSIFPTSQYQIPVGGKLDLIVKLVIISPVISRITCELESDNETITSSAISESVNKECKFPLTFKNDGSVNLKVTVKLKNVGDSEIMYIINFPKITIFSNYSFYSGWSMENSTENGIISVDGNSFKKGCSISSNDNSNNCTISNNIKYITNLPKLNISNDLNELFLNGITSINSNELVTITTRIDSETKYYQIQLFFIHQPIDDQPTPLSIYIENQPVFLLEPLESNSAPIFKNLTFNFDNINSLENINISFATRGNTYLTSMAIYSSLVIEYPIPVEKINLLPIIVPICVTVLVLLSILIVFFGARYYKHKKRRRLEIAVFGVELYSKKPSNNKSPVPSTPLIINSNQEQSSSNHISITVNRNSDIQTQSENNNLEPTTVETTTTTTTTAAGAILQTNVTLEMENLEIKPIINNNEPFFEDYSDEYDDSSDGAELNEDDVEDYINIIRGGNIKIEAEGELFVRQFERNTFDQEFFEYKKSKIPSPHLVPSLAHGDFIENPLNIIDILLDPVTNEIPLEHYLKTYKNRNGQSGKYRTNTQTHVLIADTIFQHCNDPDLPVSVSPYICDFGMNGRKSDLGEVCHDTITFKNKLSEPLYALFLFPEGDDSSITSSPFQSIELKPNVETSISLSVTLFSTTKYNEKVIVRFETLDVKQSWSTFVFLRLESELTNIIDFNEIIIKNYISEGTFGIVYRGIWRSSPVAVKLLKNEYVDHDEIEKEISLLERLRHPNILLYVGRFIFSGIHGIVTDYCSKGCLSKYIHENKYKITIIQKIRILIDISKACAYLHRNGITHRDLKPENILITSLNPKSLVCAKVSDFGTSKETNERYNLQTRRGTVAYMSNEILSQGSYTKSTDIYSFGMLCYELFSERIPYYSEPHWRIRELVLKNERPSLDQEIFKDTDISDIVTRCWSKNPSQRPTFDYLSKYLKHLLKKYDINNIIYDKDKKNKKKNKNNNNNNNNNNNNNNNNNNNNNNNDDHDDNNNNINDSDCDNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNN
The following text describes a protein:
Function:
Sea anemone phospholipase A2 (PLA2). When incubated with plasma, this protein shows a moderate anticoagulant activity (0.15 ug of enzyme/200 uL of plasma), inhibiting clotting induced by thrombin. This enzyme also induces myotoxicity, and edema. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Miscellaneous:
MISCELLANEOUS: Lacks hemolytic activity.
Subcellular Localization:
Secreted. Nematocyst.
Sequence:
GVWQFAYMIAKYTGRNPLDYWGYGCWCGLGGKGNPVDAVDRCCYVHDVCYNSITQGPRPTCSRIAPYHKNYYFTGKKCSTGWLTSKCGRAICACDIAAVKCFRRNHFNKKYRLYKKNIC
The following text describes a protein:
Function:
Involved in the melanization cascade in response to lipopolysaccharide (LPS). In vitro, reversibly and competitively inhibits trypsin (Ki=8.6 nM) but not serine proteases chymotrypsin, elastase, subtilisin, thrombin and plasmin, cysteine peptidase papain or metallopeptidase carboxypeptidase A.
Sequence:
MKNKAVLMLMALFLVAVTQVHGDPEPSYKARSCTAYGYFCMIPPRCRGTVVANHWCRARGHICCSSPSNVYGKNQLLAA
The following text describes a protein:
Function:
Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation.
Subcellular Localization:
Cell membrane. Secreted, extracellular space, apoplast. Note=The precursor of SCOOP22, PROSCOOP22, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP22 in the apoplasm.
Sequence:
MNKALVWLITLLFLIFSATPNRVLAHPPYISPKTRAREGVWDHKIMKVRKIGVGASNSGHSPGAGGIP
The following text describes a protein:
Function:
Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MELGDKLVGFLLTLTSLSIITYYTLWVIILPFVDRDHFVHKYFLPQKYANLISVLAGVVLVSFLSVWVL
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MASRTAISNQYEVLGNFSIGEDKKYRNDLSQRLFLVEPDDDQPNFDLLQGLREYKDTVYTGPVPTSMSPLLDWFHDHRDELIKKKVLKSEGSSRKLDIDFVGRRGFFWRLLRAVESLDKLEILVTLCNGTYYIENVKIDNYKLTAWQIELGFGGDKFAQCITSPDGRKPDINKPVNANAQYGAVMKTQYGDHRIILSTEVQAERKDSNKAPPENYVCIKTIKDDLVGKPLTNFNRYKTLQWWSQAYMAGIPEVICGRRDDRKHIITSVETMKTNQLSSKSEGYWDPRLCQKKFESYLSEIKKLVKDDDPRAVYRLKLPEIERGRGLKDKLRSRRFLLLGRKEDDYVILPDRYLKDVLGLKEY
The following text describes a protein:
Function:
Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.
Sequence:
MVATSDREGRGAEKDEEAIEALRMSSILRLSLFPLVSLASPKRVYALPLHAKSSFLGKYDSDDNPREETMKPMVDGGTEGFKGHARVIKPGVTPCFECTIWLFPPQVKFPLCTLAETPRTAAHCIEYAHLIKWDEAVKTAELFRIPGVTYSLTQGVVKNIIQAIASTNAIISVACALETLKIATGCSKTLSNYLTYNGVEGLHIKVTEFVRDKDCLVCGPGVLIELDISVTLQKFINMLEEHPRLLLSRASVTHRGKNLYMQAPPVLEEMTRSNLDLPLFDLMGKVPRDVIHVTGMSRKDDKKVSSLMKLRVAFKGVDGVVDMDMAGGALFHHLNAETFLTDLVETQWRDMTPEL
The following text describes a protein:
Function:
Major secreted protein that belongs to the subtilisin family serine proteases.
Miscellaneous:
MISCELLANEOUS: The pro-region inhibits protease activity and plays an additional essential role in the proper folding of the protein into a conformation compatible with secretion; MISCELLANEOUS: Its complex processing and high level of secretion make XPR2 the perfect model to study the secretion pathway.
Subcellular Localization:
Secreted. Note=Proper secretion requires TSR1.
Sequence:
MKLATAFTILTAVLAAPLAAPAPAPDAAPAAVPEGPAAAAYSSILSVVAKQSKKFKHHKRDLDEKDQFIVVFDSSATVDQIASEIQKLDSLVDEDSSNGITSALDLPVYTDGSGFLGFVGKFNSTIVDKLKESSVLTVEPDTIVSLPEIPASSNAKRAIQTTPVTQWGLSRISHKKAQTGNYAYVRETVGKHPTVSYVVDSGIRTTHSEFGGRAVWGANFADTQNADLLGHGTHVAGTVGGKTYGVDANTKLVAVKVFAGRSAALSVINQGFTWALNDYISKRDTLPRGVLNFSGGGPKSASQDALWSRATQEGLLVAIAAGNDAVDACNDSPGNIGGSTSGIITVGSIDSSDKISVWSGGQGSNYGTCVDVFAPGSDIISASYQSDSGTLVYSGTSMACPHVAGLASYYLSINDEVLTPAQVEALITESNTGVLPTTNLKGSPNAVAYNGVGI
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLWKLLRLFIIIKLIQLAIIYFSPCQFDTSSELIIQNLSSTSSSKSYYNVIITTILNKLIVWDSVYFNDLFINPIQFEHQFVFCPGWIQLIKLLNIKNYYTAQLTSILISNLCHFASVITLYYLTNEMDMKFGLVSGLLMIISPAGVFLTGNYSENLSNLLTLLMFLTYYKSINFNDVKQPSNKSITNILGYIISGIFCAINFTVRANGLLLGVIYVFDLYHFIQNKSSSQIILSIITGSILFMTFLMTNIYHYIKFCPGREWCNNTFPSLFQFAQHHYWNVGFLKYWTPNNIPNFILVLPVLIFNIYSLGYMYQELPKNRKLLPLIVINGLIVVGGTFFWNIQILNRITSFSPLIYWTLAYNLKKPWAKYAIGYCIVWNFVQTGLFAAFLPPA
The following text describes a protein:
Function:
The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSCACQDGVCNGKMDKATKTVGAETHAYSKTSSNTSIHESDDDDIWGDDEPTQTPAVKRIHTKQGYVDGLAHAQESSLQAGFDEGYGTGAGLGVAVGSILAKTWGTPAYDEARRELVITNVLSRQWFDNDLCMKKHALIQKWNQNLD
The following text describes a protein:
Function:
Under harsh environmental conditions, larvae enter a developmentally arrested state known as dauer; TGF-beta-like daf-7 acts to inhibit dauer larva formation and promote growth. May be a ligand to cell surface receptor daf-4. May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. Involved in mate searching behavior of males, acting in concert with the neuropeptide pdf-1. In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family.
Subcellular Localization:
Secreted.
Sequence:
MFMASSLPVFIFLLSLPHGLTFNCTNSGVCIEKMKQHRTEYLKNEILDQLNMKEAPKGLKPMDPEMKSVYLEMYRDLLEKDEQDMGVEMSFYTAKDPSYGENPSQLVAKFDVTNDLERSDILQATLTVSIEIPAKDSGMLQDVQVQVYEKNEDGSMGEMVTSGIFATKGSERISIQLPIDTVKSWFTISPIQGIFVKAMLDGRNVALHPQQTTADVDNMRLQLSTRPKGSRKRRSHAKPVCNAEAQSKGCCLYDLEIEFEKIGWDWIVAPPRYNAYMCRGDCHYNAHHFNLAETGHSKIMRAAHKVSNPEIGYCCHPTEYDYIKLIYVNRDGRVSIANVNGMIAKKCGCS
The following text describes a protein:
Function:
Probable pseudophosphatase required for the oocyte-to-zygote transition during which it regulates the polarized dispersal of the cortical actin cytoskeleton, the synthesis of the eggshell chitin layer and the formation of the polar bodies after meiosis I and II. Acts as a scaffold to tether kinase mbk-2 and pseudophosphatases egg-4 and egg-5 to the oocyte cortex and thus restricts mbk-2 activity to the cortex during meiosis I. Regulates mbk-2 localization to cytoplasmic foci during meiosis II. Also required for chitin synthase chs-1 localization to the cell cortex of unfertilized oocytes and to cytoplasmic foci in the fertilized embryo.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm. Note=Co-localizes with mbk-2 to the oocyte cell membrane during most of meiosis I, relocalizes to subcortical foci during anaphase I which become cytoplasmic during meiosis II. At the end of meiosis II, egg-3 is degraded releasing mbk-2 in the cytoplasm. Co-localizes with egg-4 to the cell cortex in developing oocytes and in newly fertilized embryos. Cortical localization in developing oocytes is egg-1, egg-2 and chs-1-dependent. Co-localizes in the fertilized egg with chs-1 to cytoplasmic foci.
Domain:
The N-terminal destruction box (D-box) motifs 1 and 2 act as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Sequence:
MRTSDSHLPLSNLARSDSIEFKDAVINEKWVHSANRRKGHLTPKAPEKKSGWFGGQKSEEELLMERVEQHELEELQTFIAQKLFRVDGIICDEETRILLVEKLMNAKEYPTINHDELAHRYGSSMAGWLRDRLVPSMSDCSSVLQRAAAEFYQNKMSDPLCNWGQLNPEHVSMVAARIAKFSEEMSSKVKWSLLVEPGKFSCHLTEFVQEFNRLDRMFVSNELSDEESLQTAFNANYLTKARSKMVPCAEFSRVKLNDGLGRLDDRNELRNGMFSDEHEFLQEEGYTAKSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTLGPLDSANRNHCPYYWPRAENESLRFGSFHITCMKVDSKADPLFTITKLKVQKVGGNLLDAEFDEELFLEHWQWDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWIEPYVNKWYHRAALGLRFKSIGFIQKYNAMIQEFSRITPAY
The following text describes a protein:
Function:
Co-chaperone that binds to the molecular chaperone Hsp70 and regulates Hsp70 ATPase activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSNKVTAAIIDYLKQAITTGSISEEEKESLEVAAQCIQDSFKIKPEEIKPKSGDRLVAAFEEYEKLHPVEEDSTAHVNKEEAEKLKLEGNNAIAAKDYQKALDLYTKAIEIDPTSPVYYSNRAAAYNQLGQFENAVEDALTCLSLDPHHARAFGRLGRAKLSLGDAAAAADAYKKGLDFDPNNEVLKRGLEAANKQLNQPSDSSATSGADQARTSAGAAPDLGSIFGGGMPDLGSLMNNPAVMNMARNLMQSGALNNIMNDPNIANMARNFQSGGGMPDLSSLANNPQLQNLARNFMNNNNNGNTDNNNQGNPPPQ
The following text describes a protein:
Function:
Terminal uridylyltransferase which, specifically, catalyzes the addition of Us to the 3'-hydroxyl group of single-stranded RNAs with a 3'-terminal U.
Sequence:
MPPSPAVVGRSLVNSFKQFVSKDLHTRHVDATYRLVLDCVAAVDPLMRLYTFGSTVVYGVHEKGSDVDFVVLNKTDVEDGKGGDAATQVAKGLQADILAKLARVIRQKHLSWNVEEVRRTRVPVVRVKGGGAVDFDITAYRRNGVRNSALLRAYFEQNPPCRWLSMSIKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQRNHLQFVPPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLHFFLHEFDSDKQVISLNRPGITTKEELDWTKSAEDFARMNGEKVHYQWCIEDPYELNLNVGRNVTPLKRDFLRRHLEKARDTALLTIV