lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MEQQQLDEETGTNFRLDLLSSLLGQQIASGILNYNTIDDDDEDRVPNSCPHPVFIGNSCTKCGQETNGTISTIPFWYIYPRLNVCLKEVNRIRDTNLQRLLSRRKLHLVVDLDHTLVHTRKLYKLSPEDRNFLRLRSKRYGVDYNLAGELGTLFQVGDGWTKLRPFVREFLREASTMFDITIYTLGCRAYAWDMSKLLDPDGMYFDNWRVISREDCVALDKHKKCLDVVLEHERVVVVMDDNEAVWEDHKTNLFKVTPYNYFSYFSPEDKVHDASPPRLSWSQLNGDESGENGVLAMALDKLRLVHQAFFDDNSTVKGIEDYGNRDVRQVLQRVLMKQKSLSKKQKKQQLKKINYNGLARNLQAAHL
The following text describes a protein:
Function:
Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage.
Sequence:
METKQAAHYEGYATRDGSDLISSHKNIHGNVPAPPAPASTRWRNPAQPPYRAQGAFRGGHTQRAGGFIGPAQEQPNQGWKNKYSLVNRTVLASTGTADAGNKGGRAATTALSPVCLTATVAQKSQAALSVPATEQSKLTSKGSTNSLPKPKAQTAPSKQTSAKHLAPTATPAQSAQRVGAPTAGGSSVAGKHQKRPPSQTICISSQESVRLHSQAAVPKPANPVPRTASSDSRGATPSNYIYSPPKPAASPPAPAKIPKVRKTKYTWVANSAKTSLAGKKLSPGGKKLNEENDKGQSPAASMAAPKKKVGVAPKSGTVRNRYKWKAESPGPTAKVHSAKKTQEPPVQTTPKASPHLLFKGQGPPTAPKLPLRDSAHSHYKVKSRTKIIRRRSSSSSPTDKKASPLAPVSVRSRYCLRRRSSPRVKSPVVQRRSSPRGLIHITKHKLRRLPPSKQHDPTKAGPPTTAMRSPPSSRVIKTRYRIVKKNVSALHPASPFSPFSPSLSWRSRVLLVHQIRQLSQSSRFPHPQQRWKSRGIRCIGGVMYRVSANKLSKTSSPGPVSKLSPRAGSLDLSSTSPGSLYPSRTTTPSRYIASRAVQRSLAIIRQAKHKKEKKEYCMYYNRFGKCNRGQNCPFIHDPEKVAVCTRFLRGTCKKTDGTCPFSHKVSKDKMPVCSYFLKGICHNNDCPYSHVYVSRKAEICKDFLKGYCPLGAKCKKKHTLQCPDYARDGKCPNGAKCKLQHRQRKKRPENVAQSEWPRPGGRQGQSAGASAIGSTDTASDEDLGRSRMQTLPAFISLNCSLTPTGDTSQGPAKGATTDDSGKRLQIKPRL
The following text describes a protein:
Function:
Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation. Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cell projection, dendrite. Secreted. Note=Located at dendritic tips. Secreted following proteolytic cleavage in vitro.
Sequence:
MNQLWRASCLQVLITFLLIHQNKASEKDRFVELVDCIADSFTVVLNKSDPEVMRMISNPKSQPVVYVYGHKTRHPCGTSMKDEKGLTNFNLTIPYGSECDVTLTDLPKHRYAETTVVLEDNADLSFGKTTRLNHVFCLYTRNVKTIRFSDVSNGHEVIASTGGKPKPKVEMLFRSTDSGKTLQAARENEFVEFFIALSPDSAYHGISPKECTFSDREDISAPDAKKITFVQGGCPVNGMNDIIDPLANVNDQIYFSKFRTFRFGNQSTVFVHCQVQVCLKKDECSKTCYKKVSDSNLTAERLRFRHKRSITDLERRTTRSAPTDDNGSLDLTNSLTVVSRIESAELVASPISQPTIVDTPSEQRRDPCPKSSNMGFIPLIIMGSLASLLLFSAGAAIYFGCKLKSMKKKDSFDMMSAFSNPTVSMPVTYSHYQRSAYNASVDSLYR
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MASRKSIDPQHCANGCGFYGSTEYRNLCSSCYREEIKKASMEIEEPLNQKSSPPPSNATSRFFNSAPRSAFSFHSNNISGSNSFFGASSSNTKQFSFSAASSLTDKTCISHRANPNNFLFGSSTVRKDVCNTCNKRVGLTGFRCRCGNKFCGKHRYPEEHSCSFDYKAFARENMLKQNQVCKGDTDKLRNRI
The following text describes a protein:
Function:
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTIDQKGHKTFYGEPFREDTLSQNAINNVLNNQDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVNQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSL
The following text describes a protein:
Function:
Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by nbs1 following phosphorylation, and promotes the endonuclease of rad32 to clear protein-DNA adducts and generate clean double-strand break ends. Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection. Required for the repair of programmed meiotic DSBs. Involved also in an rhp51 recombinase-dependent recombinational repair pathway.
Subcellular Localization:
Nucleus. Chromosome. Note=Accumulates at DSBs; recruited to DSBs following phosphorylation and interaction with nbs1.
Sequence:
MNEEEHNKSVHWSIVYRQLGNLLEQYEVEIARLKSQLVLEKKLRIQVEKELESVKTKQISSSASSKVSSNTIQELDSTTDEDEIPGSDTVDEEDPSLNAPFSEKNQSVKIPPHSPTLPVQNASAFVKPISVPLGNVKEEKFLDTNPIGAESFESSDGEMHLRARSPEDMILLRETQPLAPLDINTLGVSDNRQKKGTEKKRPFEPEFLNDDVIRGNKRKALPAYECPDCQKFYELHGPVKESSVAPTWNDENRLGGGSLPNCKHQPLVQKVGRHRKLNIPKPIPNGFWESDFVD
The following text describes a protein:
Function:
Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, kanamycin and tobramycin.
Sequence:
MNYQIVNIAECSNYQLEAANILTEAFNDLGNNSWPDMTSATKEVKECIESPNLCFGLLINNSLVGWIGLRPMYKETWELHPLVVRPDYQNKGIGKILLKELENRAREQGIIGIALGTDDEYYRTSLSLITITEDNIFDSIKNIKNINKHPYEFYQKNGYYIVGIIPNANGKNKPDIWMWKSLIKE
The following text describes a protein:
Function:
May be involved in the small subunit (SSU) processome assembly and function, and in the 17S rRNA synthesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAQKRKNDKIETSKKEEIDPRFVNKFEDLEENDFKDDDEDDFINDVNEGEEEEEEEDNEDNIEFNQEEDDEDEDDEENKDNKNKIKKVIKIKPMDIEKMKKLKEQNENKGIIYLSTIPSRMKPAKLKQLLAKYGKVTRMHLVRANVERKNHRNDMFKEGWIEFEDKALARKIATILNNIPMGGKARDIHKDCLWNLRYLPKFKWHHLQDKLVSQRMERDKKLRLEINQVRKQNLILLEQVELSKHVNQKHESKGKPIKEKVVRTFKQRSSHEDSLNSNISSKVLEKVVSNKKQKIN
The following text describes a protein:
Function:
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Sequence:
MDSEYAALLERAYKLVAPKAQRRAEIPKIEVENMPRKTIIPNFGQIAKRLNRDVYFMAKFFQKELAVPGTLEGDVFTLHGEKSPKVVEAVYDRFIRYYVVCPVCNSIDTELRKEGRIFIMRCLACGASTPVRPL
The following text describes a protein:
Function:
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MGLGKTIQAIAIAYFYKKEWPLLVVTPSSLRYPWVEEIEKWIPELGPEEIVIIQNKTDVGRISTSKVTILGYGLLTTDARTLIETLNHQHFKVVVVDESHYMKSRNASRSKILLPLVQNADRAILLTGTPALGRPEELFMQIEALFPKKFGTWTEYAKKYCNAHVRYFGRRIQWDCRGASNLSELHRLLSDIMIRRLKSEVLAQLPPKVRQRIPFDLPAGAAKQLNASFEEWEKLMRASASGTTENSGDFSRAMGLITRLFKETALAKAGAVKDYIKLMLQNESLKFLVFAHHLSMLQACTEAAVENKVRYIRIDGSVPSSERMHLVQQFQKDPDTRMAVLSIQAAGQGLTFTAATHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSVMWGMLNRKAGITGSTLNGRKERLQAAEGDREKWDFLSFAEAWTPRENPEEIQNETLFTQCEKEKQHDIRSFFSPRPNKKRPSSPASCNEPHSIPGADSEPLCSGDATSEGAAGSERDFEPPCKRSRSEGRHDRVPRGSQSRPGRASSSCPGARAEGVQPNPSGEALPGQQGWDCSRCTYVNSSSLPYCEMCEHPRRSHVNLSQEEEGNHACTTSGQGSVSEGCGGADVLRADSSDRQEPNQESPGTEPSAESKQRGGGGGRGCIQAEAHEEPFENSDAFPVYDGLLFCASRNTDRIHLYTKDGESMGCNFVPLDVKFDLWEDLPASFQLKQNRSLIARFVREWCCLTAMKQRILRKSGQRFSSPALALEEIMQPLSKQICTKRYITKADVAAASVNKAQSLGGSVQVVTKESRFSIQNGDLSAAEGQESPPKKLSEPEARGLVSLNSDLVDPELPADPSGSKGYVQAVDRDGNPLCLYCQQPSCQSGQQNKAIGWDWRFCSLKCQEEFGIRSSNSYLRAKVFEAERGVCQLCKQNVQELFLRIRDAPTSQRKSLLDATWTSQLPLQQLNEMIRSPAEGQFWQADHIQSVSSGGGQCPLGNLQTLCTLCHRKRTAQQAKERSRLKRHSLASKHRCDITRFLVKM
The following text describes a protein:
Function:
Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSLVPYPDSDSDEDVGGHGIAAQSPGRAPKSPIQLKRKHSQSAQDDLPPLPAAFHDLYTTNARISTSDNPELHGGRKRAMPHVEGNWPSHVYLEWNPSQAESDNLHGLIQHVKDAIDAQNKERPKKTPVPKIIPSLQSELGAPLPLHVSLSRTLQIKTEDRDVFLDALRSRLRRASVAPFQFQFRGLKWVPNFQRNRWFLVLSIEKPANNELNRLLDACNKATRHCGHPGLYVGGHGDGPMESSNENTGNKRRKGQDTEEESVDRSDRFHVSIAWNLEEPDPEWTALIKNIDVSERIKQPQASIDVVKVRIGNVVHNIDLKAGRLGGTMGLNQNSN
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MDYEFGRESGFINSQPSLAECLTSLTNPAGDAFQSSSIKSSPRSLPTLQTVSGLDTSVPPRQDRSTPALRGCSPLQTASILAEYPWMNEKKSTRGPFFMCSGSPEEPESTDDGASKRLRTAYTNNQLLELEKEFHFNKYLCRPRRVEIAALLDLSEKQVKVWFQNRRMKHKRQSHCKENWDGERKYACVKDAPGIDFQQAADSSMAAQRERCSDQHTPTSPHNNNANRRGNQAASLMSSNEKHLKHFPNPTPTAPACASTMGPDNDDSSSLDGSLQTFQPISSSSSFSPSLSESAQSPLHLPSESFNFFTETFTAMDQQNLIY
The following text describes a protein:
Function:
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MKRPQPPSSPSRCCEQFGPEAELQIPDPVSSSEVTTPGFGSFSFNMAASAVKGLTALRSRTGRPIAFIRKIPWTAASSELREHFAQFGHVRRCTVPFDKETGFHRGMGWVQFSSQEELQNALQEEHHIIDGVEIHVQPQKPKVLHGAQTSDEEKDF
The following text describes a protein:
Function:
Probable transcription regulator.
Subcellular Localization:
Nucleus.
Sequence:
MGSSSDIVPDRSPADDVAPVTDTKIPKEEPLTLRRTRPSRACTVRAQQRLQELQAAERKLKPPKKEYKREQHRRREEVVEEDEDSEDDDQEDEENDGDDESNPKQCVAGGSSTKIITSLVPPPEPSQMPRWNLRSMWELASVLNFLHVFRPLLKINAEFSAEEFETALLTPNDTLSDIHIPLLKAIPPVTRMALTRDTWVTVLCRKIRDCWHWVAEGDLPIVALQGREIEVYKNLDPAIRVVILKALCDIRVEQEDIRSYIDNSLKTGVHLSVFRKDRVGGDSHGVNFWYEEDPLIGHRLYREIRKAEVLKVKTKGSKILPNITYQWETVATNFDEFQDVSEKLLQSSSRIEVSLGKKLVKDMLPEIEKEHKRKEKLLKKQHRQALLLDNFVVVDGLAGRSLRDRKPVRYTFDDYDKSINDAIKITKKKHPSPEHPLHRRESARLDALANGRSTSSTHPTEPVNDTASGRSSDFADYDDFDEHRDESLDRRRRQRPQRYSATDFVETVSDNEVEFQSDDDIYGEAVYDEEYLKKRKQKKLSSGSEGDEEKGDEEYKWDEDNAEYEEEEEEEEEEDSLSASEEDSDEPRRAKKMPRRETKLRSRSNDFRPGLRRSKRATRIDYQQYEFSDSDKEATGLAKRKRFVEPDEPSDETGNGDFTMGSQDSEENANDPETKSGEEEEPRDVNDNADTTNGKENNQLNKSNGTTDQEEVEGVVGKRRYLDLNELAPVSGFDDGPSTVLKDDDKTDNS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MVAQPSPDKVARSTRSRPFPSSAPPIPLPLHRRRSLSSSSPVTMIPQSQSSSLQRLHHVEKRIVRVLELAGAVMEELGNSQGPRTDAVGAHCREFMLAMKDIQTTLREEIKSACEYRPFEKCDYSARIANEICCKKLEYVIEKLDTMQQNLGQSPDDI
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATLNSNPEILLRKRRNAERTRVEKQEAARRRAEAEVRQRRARQHKFVRAEALVASTLATEREKTRIQRVSKRAAKQRAGHVTGGEWLVRVRAAADGGLEREKTAYDGRATLLFVVRVRGPAAAKIPRKAHRVLTLLRLAEVNTGVFVRLTAEVFPLLQVVAPYVVVGRPSLASIRALVQKRARVVHQRAGEAAPVEMVLNDNGVVEERLGDEGVICVEDIIHEIATMGEAFAKCNFFLLPFKLGREVSGFSALSRLQKLKQREEASQTRPVSNAAAAPLVEVDVDELIGRLN
The following text describes a protein:
Function:
Initiates and terminates the replication only of its own subviral DNA molecule. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep binds a specific hairpin at the genome origin of replication. Introduces an endonucleolytic nick within the intergenic region of the genome, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.
Miscellaneous:
MISCELLANEOUS: The genome of nanoviruses is composed of six to eight segments. In addition, some isolates contain subviral DNAs.
Subcellular Localization:
Host nucleus.
Domain:
There are 3 rolling circle replication (RCR) motifs. RCR-2 is probably involved in metal coordination. RCR-3 is required for phosphodiester bond cleavage for initiation of RCR.
Sequence:
MACSNWVFTRNFQGALPLLSFDERVQYAVWQHERGTHDHIQGVIQLKKKARFSTVKEIIGGNPHVEKMKGTIEEASAYVQKEETRVAGPWSYGDLLKRGSHRRKTMERYLEDPEEMQLKDPDTALRCNAKRLKEDFMKEKTKLQLRPWQKELHDLILTEPDDRTIIWVYGPDGGEGKSMFAKELIKYGWFYTAGGKTQDILYMYAQDPERNIAFDVPRCSSEMMNYQAMEMMKNRCFASTKYRSVDLCCNKNVHLVVFANVAYDPTKISEDRIVIINC
The following text describes a protein:
Function:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Sequence:
MTIISQRHHLACSAGKKPWIFVLWVNLCCPRRLTSTFNLPPLVKFLALCKSKTISPMLPIQHSHTLKSFYSEFIRLWFPTRTTSVLHAAVQDPFKVETVKLILERGADPNAIDQNGRTPLHLLAGIDDIYWELNESMFKTLVDAGTHLDMAADYGKTVLDVLKRNVARATTEAKSINPYLHSVSGTVFPLSCYCTRVIGKRRIRHDEDRLPLHLQEFMSRHCAAQGN
The following text describes a protein:
Function:
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
Sequence:
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
The following text describes a protein:
Function:
Nuclear factor that influences the activity of genes involved in vulval development.
Subcellular Localization:
Nucleus. Cytoplasm. Cell projection, axon. Note=Expression is restricted to the nucleus in most cells, but it is also expressed in the cytoplasm and neuronal projections in neurons.
Sequence:
MKQTTRPPAQYIVAPGTRFRLVANEYDKNKYGQCNYASYRTLVRCKQIRSKEELAKHGGRCEEHVEFSKTLENNHKKEVMRCHAENDSKMQRRRFDPWIASNEYISDDDDYLQAAQTVPQRLPDVANDDILDNNSLRYAEYYTDKDILNIKMDLVQKDIDDLIEFKELVTSQAQKEHELLGNDEEEDYPTDMAQRRIFKASTKYSRNDYLTLTTIDPVFHQCCVGPDMDDSLVIVHTMHSILDKIDNFEPIDSEKQCNKPALHLSKFCFDHIILDRSQKMFDVCNACGLTAIGGVDPKCSFHIKSSAIAETTSCPCNRCVQPGEHASPKDEKNSITCYLNSSDDDEPTLGNLSRIESMVSPMQQFSNQSNTLTAPLPRRYQGPPAQVLRPPQMGPPPGINQVPYQPKANRTPPMTSQQLHEQQKLKMQEEEMMSQTCASDFRVRPIDASQFGGGKKKQRLPPRRSPSFGTSPNSYQFHQQSQKKMPSIISTAYNSSPGKMNFQGWKNQSTSSATRPLPQPRFPVHAARSQQPKMIPLEQTQDSIEDDIGPSPMFQGPEPSRRGVPYYKNAYRRTELPSRHAQHSPLTPSTSTSSSQLLAPPKSPQPGTSSQTFRSQASRLPIAPHRAIAAGLNPADVGTRPAYRSQMAGQRPGMTPSAQQGSPQLISPPRQGSMMPVAMNQSPQAVRRQTPVPPYRLMGPQRVTTSYTVVRSGSSSSVAGPSRSSVASGSQHTALDTVQHDPRLANINVRTFLSIGNRDLSTLTQDEIDLLMAGNSPEKGGRKAGAPGAKESSKAAGGAQKGTSAASTSVPEPTKSSESSVDPQSDVSFSNPSPAPEVIEKVAPAAMTITSNKRKIDETLASESTSSEATLIHDTTSSSSAETVSGEPPAKKSSDVSAPVPSPEKEKEKIDRPKTPKSSTKRTTPTPSGRTPRAAAIAANQAISHSKPNVPSASTSSSAASTDQENPLDLLAELSVAAAAEEQQQAIGSTSKNGGSTKKTQRKSPSRSSIGKKRENSEEYEEEL
The following text describes a protein:
Function:
Response regulator of 2 two-component regulatory systems SasA/RpaA and CikA/RpaA involved in genome-wide circadian gene expression. The histidine kinases have opposing effects modulated by the clock oscillator proteins; SasA phosphorylates RpaA (stimulated by fully phosphorylated KaiC1) while CikA dephosphorylates phospho-RpaA (stimulated by the phospho-Ser-432-KaiC1-KaiB complex); The RpaA regulon is about 300 genes, and includes itself, cikA, sigE, sigG, genes involved in photosynthesis, carbon metabolism in the light and dark, phototaxis, CRISPR arrays 2 and 3 as well as nearly 90 ncRNAs. Genes are up- or down-regulated in its absence. Involved in regulation of primary sugar and amino acid metabolism and in adaptation to light changes. Regulates the accumulation of the monomeric photosystem I and the D1 protein under high light conditions. Overexpression causes cells to grow more slowly, increases levels of transcripts for clock oscillator genes in the light and the dark, increases levels of SigE protein, increases accumulation of sugar catabolic enzymes in the dark with concomitant decreases in most sugar metabolites. Plays a role in cell division; overexpression from the psbAII promoter increases expression of some cell-division-related genes, alters cell volume and changes the outer cell membrane and cell wall appearance.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRILIIDDDPAISDLVSINLEMAGYDVQQAVDGIKGQALAVQLQPDLIMLDLMLPKVDGFTVCQRLRRDERTADIPVLMLTALGQIQDKIQGFDSGADDYLTKPFDVEEMLARVRALLRRTDRIPQAAKHSEILNQGPLTLVPERFEAIWFGKSIKLTHLEFELLHCLLQRHGQTVSPSDILREVWGYEPDDDIETIRVHIRHLRTKLEPNPRRPRFIKTVYGAGYCLELSTEEGGGSPT
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
Subcellular Localization:
Cytoplasm; [Isoform 1]: Membrane; [Isoform 3]: Membrane. Note=Colocalizes with CDC42 to plasma membrane.
Domain:
The CRAL-TRIO domain is involved in interaction with inositol phospholipids; The DH domain is essential for transforming activity and directly catalyzes GDP-GTP exchange activity. It may interact with CCPG1.
Sequence:
MAEANPRRGKMRFRRNAASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY
The following text describes a protein:
Function:
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
Sequence:
MSKVYLLDYVAGNVRSLVNAIEKVGYTIEWIKSPEDVPKADKLILPGVGHFGHCMTQFSSAGYLPAIRKHIESGKPFMGICVGLQALFEGSAENPAVPGLGIIKATLDRFDDSSKSVPHIGWNSANTSGEEVYGLRPSSKYYYVHSYKVPYKQGELESQGWTVATARYGDEEFVGAIAKGNILATQFHPEKSGVAGLRVIKAFLDGNNTSSAVEGLVAAKEGLTRRVIACLDVRTNDQGDLVVTKGDQYDVREKTDGGNVRNLGKPVEMAKKYYEQGADEVTFLNITSFRDCPLVDVPMLEILRQTSKTVFVPLTIGGGIRDTVDTDGTKVSALEIAKMYFQSGADKVSIGSDAVTAAEEYYSRGKKLSGTTAIEQISGAYGNQAVVVSVDPKRVYVSKPEETKHNTVQTKYPGPNGENYCWYACTIKGGRETRDMDVVELVTAVEAMGTGEILLNCIDKDGTNSGFDLELINQVKNAISIPVIASSGAGNPGHFEEVFSKTSTDAALGAGMFHRGEYTVKQVKDSLAEKGLMVRQFESDL
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MVRVKSRYLLIHAVPSGIGEPIDIAKGEFQTLIVAGVRQLYGIFGAGCCLKTGIIYTNWLKTGIVIIKCRFERLNMIKTTMKYFGSERLPFPFKMNVVHVSGTIRSCKREAIKYDSRATF