lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Synapse. Postsynaptic density membrane. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane.
Domain:
The PDZ-binding motif is required for neurite outgrowth promotion. This motif is also involved in DLG1-, DLG3- and DLG4-binding (By similarity).
Sequence:
MAPGPFSSGLFSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRKVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSTSERRLVAAELTSSSVLIRWPAQRPVPGIRMYQVQYNSSADDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRIKGTSRTPPRVSHVCSQTNGAGAQQASAPPAPDRYEALREVAVPAAIEAKAMEAEATSTELEVVLGRSLGGSATSLCLLPSEETSGEESRAMTGPRRSRSGALGPPTSAPPTLALVPGGAPARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARARLAFTSTEWMLESTV
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEAVRKLIDGHIDFQGQRLADRIMQEGLVLGATVAFLLGYLTQNMQLCMLTFAASTLVVALVTVPAWPMYKKHHVKWLPSSSSSTS
The following text describes a protein:
Function:
Catalyzes the conversion of trans-anhydromevalonate 5-phosphate (tAHMP) into isopentenyl phosphate. Involved in the archaeal mevalonate (MVA) pathway, which provides fundamental precursors for isoprenoid biosynthesis, such as isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Sequence:
MSDLRNYISKIKKNKELKTVKTKVSTKYEIAGITAKVDGSHAVLFENIKESDFHLVANLVGTRKRFALAVGGTEYNIHEKVISAIKKAKAPKIISSGKFQENSSKNLLSMPIVTHFEKESGPFITSSIAYAKNPETGKQNSSFHRMMPIDKTHFSIRMVEGRHLHRCFIDAKEHGEDLKIAITVGVHPAISIAGAYQAEWGKDEIDIANSLLGGKLTLTKLPFTGLNIPSGSEIVMEGRVLQDKTHPEWMVEMLQTYDHERSQPVFELENMYFRNNPIFHDVLSGYSEHRLLMGMPIESKLNGDLKKAFKQTQQVSMTNGGCNWLHAVVQIKKKHDSDAKKIIKKTFESHRSLKQVTVVDEDIDPNSAEAVEYAMATRFQADKDLIILKNVRGSSLDPSSNQKKLQTAKMGIDATRSLSKRPEGFELAKIPKIDKIKLEKYFK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MSFFSNLFSKPEDKLTSFQVSKAPTFEEFKKTLKDNGVSDTTFEDLFEKMVLMTLTSFLEKYPSKETSKCQHIPTQPEWFYSCKTCCNESNYYCRNCFFDGEHIEKGHSISMTENSSGRVCDCGGEGIKPEAYCSKHIKSNEKVKQELLSKIPSFVKKDIHIFFRYSLQYLQYLSTTSATQPTISEENKEETILIGSWFIMIASISSSLVHMAAEETSGRVLDSLENGEFKLNEHKPLPYKIETHSMDGNSDIIQPFASKNSSLLSFVFGNSTALHSLLPLIIILYDNHKNFKLVVIEEFLKNYSNLFKNRDQVSTDISLKMSSLYLGNSLISKFCTDYSKYNYLELVLRAHKNYYVPLLLPFYQTSNPEDIKKDVMLQTDLENFPRLMKSANIVKYFVTDEEKMDLFFELAGSYHKFTTLEYIDPSISTCKFLLNTEHYLVNTIRNILTTIESEKDFIFDSETLKKKFLDSTIKSIAEKLVKNIKELKKREMTNRCGMMLEHKDFFVNFTYAEIPVHFPLFRILSAFLLLSGMDPMELLTTKYNLTQADITEMVTTILLFRFCYITYDIQSSTENITDISMLYDLHILQVGLCLLGTKKFLLTFFNALSSISHGNNSKVFVDNLSLLISVFQTRANLAPTKTQAFYHLYQGAMSGLFFKVHFRSFDMILPGFTENDICEKHIEEFTTPGETEKLLLDQTNWKYYDKYYPYFSLNYRDLISSNCSKKYKAYQESLGLPGNFNPLPPQLEELPSQLSGVYSALNDQYLFEMIFNVLVAPLHSTFVDYENSFELQSVIKRLFSSVPVPPINEFFYILTLTFKSFKEQFLPKLQDSEKLELQQSLQEYFKLDSENKFTFKFQSTIKENAITHLLQVYHVNLGESNGKVMLSLYDLLLKYNEIIKKDNLLYSEYTSNINYVFNILFEFDSEIFNQFKQQSNVVAAVVDVAASAAAVDNSTTENTTTTTSSLNVEDSLKDLNIKDDSTTTTTTTVDATATTTTNEETTKNCVICNGNEEVGRLFSMSYIDLSSVTFQNATRTVYQYSKDKENGYDPRYQTFLENFYFIDIKPGTSQYIPYKDDPAPLFACYLFQRCPSTYISSCGHNVHKKCLEKYNKTNPPPVNTLFNNTYKCPKSGCSRECDILIPLGKPDTSLDFKSSANELFSTMCYFDFLALMEKENKYSIDKYLWKFVLQNIETLELKSRKTKLYNESENDPEYHLMSEQEFQNEMLTTSRLFKVVMTADVEPEPLLPIYDQSTFFMDPFTSSSYSVYLEPKEQPIELLFKGLALYLFNVLLNHCFRNKVVPSESADNPTIVSKLIIEEFNKLFFDDSNKLKQLDQKVYLEFKNQIHPYLRKLLIFNNLYKPESLKSSTTFDISLDVLSDFNQCMKLLFNFDSIELLFSQLVTKDYLELTLNFFMKKRKLSSNISSFPQLLCTYPPPQQYDFLPDFFEMLPKYADSIKENTDVGNCSVCKKINKMVCLVCGVGICPSTTCKLGPIVHLYSCQSAPIGYYQHVPSPSLFVYITKHSIFTRSFSTSIYLDKNGKKPTDLSDCNLTLSKKELKKLFINWMNHSNSNFLIKNK
The following text describes a protein:
Function:
Catalyzes the formation of putrescine from agmatine.
Sequence:
MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHHRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLSAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPHHSVQIGIRTEFDKDNGFTVLDACQVNDRGVDDILAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
The following text describes a protein:
Function:
Transcription factor involved in defense responses that functions downstream of RAC1 and upstream of PAL1 and WRKY19 genes.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes mainly in the nucleus.
Sequence:
MELDEESFLDELMSLRRDGSAPWQAPPYPGGGGGGGGGGMMMSDLLFYGGDGGSAEARGGMDASPFQELASMAAPPPQHPHEEFNFDCLSEVCNPYRSCGAQLVPSEAASQTQTQLTPLRDAMVAEEETSGDKALLHGGGGSSSPTFMFGGGAGESSEMMAGIRGVGGGVHPRSKLHGTPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYVKELTERIKTLEEEIGVTPEELDLLNTMKDSSSGNNNEMLVRNSTKFDVENRGSGNTRIEICCPANPGVLLSTVSALEVLGLEIEQCVVSCFSDFGMQASCLQEDGKRQVVSTDEIKQTLFRSAGYGGRCL
The following text describes a protein:
Function:
ipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis. Involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the PM in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/PM interface, SAC1 drives PS transport. Binds phosphatidylserine and PI4P in a mutually exclusive manner.
Miscellaneous:
MISCELLANEOUS: Present with 2350 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Cell membrane. Endoplasmic reticulum membrane. Note=Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites.
Domain:
The OSBP-related domain (ORD) mediates binding of sterols and phospholipids. It displays an incomplete beta-barrel containing a central hydrophobic tunnel that can accommodate a single lipid molecule with a flexible lid covering the tunnel entrance. The ORD can bind two membranes simultaneously. It has at least two membrane-binding surfaces; one near the mouth of the lipid-binding pocket and a distal site that can bind a second membrane. These structural features correlate with the phosphatidylinositol 4-phosphate (PI(4)P)-coupled lipid transport optimized in closely apposed membranes, such as organelle contact sites. The lipid transfer cycle starts from the association of the LTP with a donor membrane, which accompanies conformational changes that uncover the ligand-binding pocket. The tunnel opening is generally mediated by displacement of the lid covering the binding pocket allowing uptake or release of a lipid molecule. The LTPs extract the lipid from the membrane by providing a hydrophobic environment as well as specific interaction. Dissociation from the donor membrane shifts the conformation to a closed form. Then, the LTPs loaded with a cargo lipid diffuse through the aqueous phase. Lid opening may be induced by the interaction of a hydrophobic side of the lid with the target membranes.
Sequence:
MALNKLKNIPSLTNSSHSSINGIASNAANSKPSGADTDDIDENDESGQSILLNIISQLKPGCDLSRITLPTFILEKKSMLERITNQLQFPDVLLEAHSNKDGLQRFVKVVAWYLAGWHIGPRAVKKPLNPILGEHFTAYWDLPNKQQAFYIAEQTSHHPPESAYFYMIPESNIRVDGVVVPKSKFLGNSSAAMMEGLTVLQFLDIKDANGKPEKYTLSQPNVYARGILFGKMRIELGDHMVIMGPKYQVDIEFKTKGFISGTYDAIEGTIKDYDGKEYYQISGKWNDIMYIKDLREKSSKKTVLFDTHQHFPLAPKVRPLEEQGEYESRRLWKKVTDALAVRDHEVATEEKFQIENRQRELAKKRAEDGVEFHSKLFRRAEPGEDLDYYIYKHIPEGTDKHEEQIRSILETAPILPGQTFTEKFSIPAYKKHGIQKN
The following text describes a protein:
Function:
Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate. Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as a tumor suppressor (By similarity).
Subcellular Localization:
Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFPASWRSEEEMAAEAAALRVYFQ
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MVNKSNSLDELLKQIKITEIIQHYGVKIQTKGNSLLALCPFHDDKNPSMSISSSKNIFKCWACNAAGNGIAFIQKHDQLDWKTALKKAIEICGIKLENWNSNLLTKVDPKQKRYWEINNALITYYQTRLKRETNPNGMNYLVEKRKLNKTLIEQFQLGLAFHNEDKYLCESMERYPFINPKIKPSELYLFSKTNQQGLGFFDFNTKKATFQNQIMIPIHDFNGNPVGFSARSVDNINKLKYKNSADHEFFKKGELLFNFHRLNKNLNQLFIVEGYFDVFTLTNSKFEAVALMGLALNDVQIKAIKAHFKELQTLVLALDNDASGQNAVFSLIEKLNNNNFIVEIVQWEHNYKDWDELYLNKGSEQVILQANKRQNLIEYLVSFFKKQQLDQRVITNKIIAFLTKNQTILNDHSFLIFLIKNLVKLLEYSDEKTLYETVLKHKEKLVSKFDNNRFYINTSGHAQPPQELQKTTAALVQTAFEEAVNELWKPEIFAFALIDKRFLVELKQSHLDEVFKECNFNLFDVELFIEKARIYWSENQTANWVGFESVLDQNYLLNNKARLLEIKDIFLDELTCYQANDFQNYLKTFQTLLKQQKQRLKNLKLTL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MIDENFKKKLAVSRERVEDLFYFENSKEIGRGTYGLVYKAVPKHSNGRFPNKEYALKMIEGQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKHHRTAKTKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGGPDMRGRVKIADLGFSRIFANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDTDWPDMKKMPDHQRLLNDARNEGTPIQTFPNSLQRYFDKWKINSQSSPYRLLVKLLTVDPLKRVSCEEAMNDIYFRKMERPPRETDDVFNRYPIPYAKKEQQITIPIDQFQQQQQQQQQQQQQQQQQQQQQQQQQMQQPQIGPPQMMGQPQMGQPQMGQPQMGQPQMGQPQMGQPQMVPSQMGQPPMGGPHPGVVAPDGHAHQMMQQQHQSQHHMQYQQMHDSMQGGMDDGGPQAKMMRMGNVPVGRYGPMGPPYGPQDFHAPQGPPMMQMMPQPGPSGYYQQRPGQPPGPGPQGYMNPQMGMTMGMRPQGVPQQAYMPGRGMPPPQGPNPQQQQQWQQYHR
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAILRIKEQEVSYSYLYIVVSYIVIKYLLEQFINLRQLDQLSVKQMPIHIEQTLGITQKQFKRSQRFYYDKLSFEMYTKSIKTAIEIIVILCGVMPFIWERTVTFFKMDPNSEFQRGLAYIFVEFLRLKLIDVPNNFYNTHVIEKRYDLSQISFALQFSDLVIESALWVVFVPILLYSYLYVAELGGDYFFIAMQFFVLIMAIVSSLVYPNYIQPLFNEFEELKETQLKQAISQLAFRMNFPLEKILVMDGSKRSDHSNAYFFGMYSKRIVLYDTLINNLTNEEIVAVVAHELGHWKYRHPYIKLVFFCIKILITFYIFGFYRDSDVVFLSFGFKEKSIFIGSALFFSLFEPMNTLFQIFELHLSRFFEYQADMFANRHGLGSYLMSGLIKLFKQNSTNLMVDPIYQWYYNSHPSLFERLKYLNKLR
The following text describes a protein:
Function:
Involved in protein import into mitochondria. Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis. May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix.
Miscellaneous:
MISCELLANEOUS: Present with 1520 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Soluble matrix protein loosely associated with the inner membrane.
Sequence:
MIPRTRTLLQSKIPITRYFARCWAPRVRYNVCRTLPAAALHTNIIAHNEVKKDDKKVHLGSFKVDKPKMMIAFTCKKCNTRSSHTMSKQAYEKGTVLISCPHCKVRHLIADHLKIFHDHHVTVEQLMKANGEQVSQDVGDLEFEDIPDSLKDVLGKYAKNNSENASQLPHPSQK
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Nucleus.
Sequence:
MRNLMGDEGLGDDSPPVSSGEDLWNGKRRSLDAKDDLGIQSRKKHRSGENSKSELELGSAASDCCCESGLSKASDGGCHSDKRDGSGSSGKRRRTSGELQVGDDDDSVEDDRNKKRRKTRWSSFDTRIKLLGPLQLPDFIKESVLESDSNPEIVKLKAELAELNSELQKPVLHDVQPAEKRPPSPETVHNDLGIIVNTHEVRLREELVRKRQGIILKLIRKHPTFNTPPSRKPSKLFKKLYVPVKQYPGYNFVGLILGPRGNTQKRMEKETGARISLRGAGSFARGKHASENDDLHVYIEADNQESLDAAAGMVEKLLIPVDARMNDHKKAQLEEFSTLKKFYPKAKGLCFMCGMQRHPNHACPDQPSTSTSVSCNTSSSNGYLHVSHLPLTVDDDRLKELFCPFGKLVEAKLIRDNNTGVSKGYGFVRFENPADAAVASSHLHGFKMGKKKLTVKMAGKAKVGESVSPSVASQTACPDPPGLLLLEPQGSRSPSITNHTTQPVPRESPLVEASICSAPCVATQLFFRLVSIFITVFIGAVPWSSQLSLLIRNYP
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDIGERVKKIVVEHLGVEPEKVVDAASFIDDLGADSLDTVELVMAFEEEFGCEIPDDAAETILTVGDATKFLEKNAKS
The following text describes a protein:
Function:
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Sequence:
MKVMKFGGTSLANWQRFSMAADIVAKAATMEPVATVLSAPATVTNALLEMVNLAVKGEDYSPVIQHVERVFTSLYQDAVSSGLSSTQSELLFAGLGAQLARWQDRLHGITLLQECPDGICAEIVVAGERLSAALMEQVMLAKGITSAQLDPRKLFLGRGRPLESVVDIAVSKPRFKNLLLDEKRVWVMPGFTAADEDGKVVTLGRNGSDYSAAVLAACLDASSCEIWTDVDGVYNTDPRVVADAKLLSQLSYQEAMELSYFGAKVLHPKTIAPIAQFHIPCYIKNSFNPDAPGTLVSNLADASGLQVKAISNLDNQTMFDVSGPGMKGMVGMASRTLAAISRSGVSVSLITQSSCEYSISFCVATSESAKVKLALEQEFELEIKSDLLEPIEMRHDLAIVSLIGDGMRTHKGVAARFFQALAQASVNIIAIAQGSSERSISTVIEQRKTKHAVAACHQGFFDVQQYLDVFLVGCGNVGAGLLEQIKQQAIVLKEQHISIRVCGIVNSSKMLLDSAGIDLNNWQNLLADSQQSSDLPALLAWVKEQQLLNPVLVDCTSSEQVSNQYLEVMNAGMHVVTPNKKANTRDYAYYQALRQTALTQRRQFLYETNVGAGLPVIDNLKKLLFAGDKLHKFNGILSGSLSFIFGKLDEGMSLSEATKLAREKCFTEPDPRDDLSGMDVARKVLILAREVGLKLELSDIVVDSVLPESFDDSGDVESFMARLPEADAAIAARVAEAKAQGKVLRYVGQIEEGACHVRIAEVDATDPLYSVKGGENALAFYSRYYQPIPFVLRGYGAGTEVTAAGAFADVLRTLNWTREVSV
The following text describes a protein:
Function:
Connects telomeres to the nuclear envelop (NE) during both vegetative growth and meiosis. This connection ensures clustering of telomeres to the spindle pole body (SPB) when cells enter meiotic prophase.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein.
Sequence:
MSGSKCCSSSNTIKVSIYLFLHTLTYGLLNYHLNPRLLASTGVVESDIPYWMSYLSIIMHVGQSLLLQKFNLGYGWLLLTKYPVYVLLSTYYLTPLSQIAWAFIIDAISLLVARCFSRANPIKCSNQVNTQYSVSFLFTIMASVLISVLNYISQKIFLNGLILGNSHNVVTSLVAPPLPLQYLAHVPIGYVIQRVVFSERPIPQSLFLMIFLTLWNCFIPYSILFSMNWSAMFQVVGAYLSQIWIITFICWALSL
The following text describes a protein:
Function:
Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.
Miscellaneous:
MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome.
Sequence:
MKSSKQLVQDAKDYRFNPAIPLRIYLKTCIGILEKAQCAFQANDLSLSFIYYFRYVDLLTNKLSRHPELLRMDASSSSSSSYIHKREYLQLIKLEVPAVCKIIESLRTQIDSQYSKLQTSLANNIAKPNINANTTPVQVEQQPLPKKSFDEYSFNQSISFFQKISNAQLNTGASSQSQATARDEAYRLNYPELPRLTFST
The following text describes a protein:
Function:
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.
Sequence:
MAEVIEQETQLCDNCKREIPTPNFTIHEIHCRRNIGMCHICKEPVPKSEMKTHMESEHSQVTCKCNMKMERRQLTNHEALECPLRLAVCQHCELELAFLKLKDHEDYCGARTELCGKCGRNVMVKDLQAHPEVCGREGEEKRESRSRPSHGYESEEEEEEEEEEDGAWFIAQTVQNLLGPENPTRPLRRLSRSLENPFYSHLIVDQMARNPNRGAGSAMQLDQNRGEEQERQKGNKSKRSPTVSGEEDAHLDYMLALSLQSESSVPSGATTHLEDFWRAVCAEDLGPTGSLGQAQDANLPYAEPFLATEGPNELKNNETMLPCEFCEELYPEEDLILHQTGCNPASALASFGKRSSPPSLSQDRGDRENHEDQFQRFLDLPASRAISSRFRSPLDLSAAPSGESSIIIPCEFCGVQLEEDVLFHHQDQCDLRPGTGVPVQWLLPAYESLPKQGSSQPETSPELPRRRVRHQGDLSSCYMDDIRQEAASKPAYPLPPSRPVSSLGLARNRLPKAATDSRPAVLPSPPRALKANNLESLDLIRGQSRSGHSPAAGPISVVRPTRSFYPESYVPSFPRVPPVRHGLSVRNEGGRNPRMTSTAANFRNGTSKTKSPKPAAGDAEEEEE
The following text describes a protein:
Function:
Regulatory component of the inositol phosphorylceramide (ICP) synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. Helps the medial Golgi localization of IPC synthase in a COPI vesicle-dependent manner.
Miscellaneous:
MISCELLANEOUS: Present with 3420 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MRSSLLTLPKSFLGFMPLYLAVEIVLGISILNKCSGAYGILALFTGHPLDFMQWIAYLWSVFTLIVFSQGLYLIHKPNLLVFSQICVLYTIDTISTCFFTLWFTTQWFTLEDTANIDGNNALQSNPISTGKLTERGIDISKQSATESYEYTMTILITLVSLIFRFYFNFILASFVQELLHHPKYLVDRDDVEQNLKNKPIWKRLWAKSQKGCYKLCKNLLE
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MQIIFKDFKKQTVSLDVELTDTVLSTKEKLAQEKSCESSQIKLVYSGKVLQDDKDLQSYKLKEGASIIFMINKTKKTPTPVPETKSTTGTSNVENKSTTESSTQNKAQGSTNESTTTTSSSSAPAPAPAGATTTTSEQQQPQPAASNESTFAVGSEREASIQNIMEMGYERPQVEAALRAAFNNPHRAVEYLLTGIPESLQHPVAPAQPPATGTAPAQQTEGNTSESGQQGEDEEHEGDESTQHENLFEAAAAAAGAGAGGAGSGAGAGAGSAEGDIGGLGDDQQMQLLRAALQSNPELIQPLLEQLAASNPQIANLIQQDPEAFIRMFLSGAPGSGNDLGFEFEDESGETGAGGAAAAATGEDEQGTIRIQLSEQDNNAINRLCELGFERDIVIQVYLACDKNEEVAADILFRDM
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MNQDSGAAASLSNGENKKRSFEGKMVNGEPKTAPGTPTVNGAPSTGPGSALAVSAPLVPTPDALAELPPEIAHITQEHYHPLSTLLLRISQETYNDLSETLQAMAQMPLAPQTNGVMTNGAGAHRNAQKNEEAIKIYTNAAAERNPDIATAIEILSTGKAPWMPSLGYIPPEPISPEQALKLLRYVNTTMSIRLNVHESLPRHLQDWRIESGRTTFVMGKELEFDVISFSEDTSEQWWLVDLRLLFSPAPTITVNSHFFERVQMQANAISKEKGLVGLFDFFNNFVLTHKISVLRSQALALVRSEWAGSLKVENVHRELVVSYWTDRPTKKNWIELGISKNNTRKGKSSWRGQSLPSLNMRWFRQGVEVKDFKLDFDWHNLSFERVIKRIIACHASDILRSTHESLNPQLVAGSSLSDSEPADCKLQVSLGTSGNAATLSLEPVTGSYILQPATHVTARAEHAFNQGREPKVMANILTEVLAQTLHELVQKHAQQLGWHNINRPALPSDSVKSAVKLAVIRYAMYTPRGWSSTWALGNVVDATGSSWWIFEIGKNGTAIEHAEQIKMDRPDGSTLAITRSTLASLERVAVQLLSARVTVRQLEKEKKQFSLRYELGQQKRKMKTSVAADMQKLMAASPQKGFKFSADGSFRILLSTPFGQDILGELRGRLRDVNRLRSFATTLQKREMRLGSSSLQRVEFRYGPSSHVAAVSFGAEKEIAIEMSHKNPHHRVHKMLTDIANSHNQQLPGIFTGDANGLDRFCTTLLVTRPLVTALQALEANDANVNARNPATHVHSLFKYRLAYENPVCTFDVRVQPKDDKVYWFIEDNMKKHTPDLRPTPERYPTHQRLETLQEKLKEFFSSKGERWFGTRNGLVAEIDGVGEALSKLNECVLSCTMEGGYKAPPPLVLPAAQPQTQQPQAQQPQMTGQQQQQQQQIANQQRLQQQARQQQAQQQGQRRPPQQNQQQNGRPQMQNGRPPQQQQPQGRPNGRPGQGQDVITID
The following text describes a protein:
Function:
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MPVPALCLLWALAMVTRPASAAPMGGPELAQHEELTLLFHGTLQLGQALNGVYRTTEGRLTKARNSLGLYGRTIELLGQEVSRGRDAAQELRASLLETQMEEDILQLQAEATAEVLGEVAQAQKVLRDSVQRLEVQLRSAWLGPAYREFEVLKAHADKQSHILWALTGHVQRQRREMVAQQHRLRQIQERLHTAALPA
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MEPFYPVVKEEYPSNKQSAIINMPQPMEGLHDVGPPPFLTKIYDMVDDQSIDHIVSWSRGGQSFVVWDPHAFSVNLLPRYFKHNNFSSFVRQLNTYGFRKIDPDIWEFANEGFLRGHRDNLKNIKRRKTHSQQATNQPCVEVGKFGMDGEVKHLRRDKQILMMELVRLKQQQQNTRAHLQAMEMRLQGTEKKQQKMMSFLAKAMQNPDFVQKLVHHGKRKDLEECSIMNKKRRMIDHGEGSKVIKDEPEEWEMSELDALALEMQGIGRSKSNQEEVANFDLDDKELDEEFWEELFTEQFGMIENEGL
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MADLAIPAVVQRNVSQLEIAVSDLQRHIRLLTSPESRESIQLLSPADRASYFLAIAKAANALFCLHLRTTGQDPEKHGVKSELERVSVYNDKVAAAIDRSMAPSRPTSAINVPAANRFIEHAIPDLTEEQKQKVREISRGGKRSMTWVRNPNEDSQTKKKLSVSEAAAAFLAEATKDLVPTAPRQNPLPDI