lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Salicylic acid (SA)-binding substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of NPR1 in the absence of SA. Together with NPR3, acts as receptor of salicylic acid to monitor immunity in a NPR1-dependent manner and induce systemic acquired resistance (SAR). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways.
Subcellular Localization:
Nucleus.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MAATAIEPSSSISFTSSHLSNPSPVVTTYHSAANLEELSSNLEQLLTNPDCDYTDAEIIIEEEANPVSVHRCVLAARSKFFLDLFKKDKDSSEKKPKYQMKDLLPYGNVGREAFLHFLSYIYTGRLKPFPIEVSTCVDSVCAHDSCKPAIDFAVELMYASFVFQIPDLVSSFQRKLRNYVEKSLVENVLPILLVAFHCDLTQLLDQCIERVARSDLDRFCIEKELPLEVLEKIKQLRVKSVNIPEVEDKSIERTGKVLKALDSDDVELVKLLLTESDITLDQANGLHYAVAYSDPKVVTQVLDLDMADVNFRNSRGYTVLHIAAMRREPTIIIPLIQKGANASDFTFDGRSAVNICRRLTRPKDYHTKTSRKEPSKYRLCIDILEREIRRNPLVSGDTPTCSHSMPEDLQMRLLYLEKRVGLAQLFFPAEANVAMDVANVEGTSECTGLLTPPPSNDTTENLGKVDLNETPYVQTKRMLTRMKALMKTVETGRRYFPSCYEVLDKYMDQYMDEEIPDMSYPEKGTVKERRQKRMRYNELKNDVKKAYSKDKVARSCLSSSSPASSLREALENPT
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MDYWEWKTDGAGLEADEVCITVQHGVTLYDKNEKTQRQNGKLSLTTHHLRYNDEADISTVLQLPLELVRRSGQAPSISSGFGPFSSAKIIVPLPKNAYVKLSFRSGGVDNFYAALVGALKKKTWLQTKTEAAASGRGSSSGASPASTTPVPNSRPPPPVPRGFGIAGVQQASLQSAAMSETLKDIDDVMNKASKLVNNIRRLRERSEAAAAAGSDAGSETAVERTTIESIESTLGLGAIVTRNHSNGSDSRFYRDLAVEMHTWMTHECNSKLFNDMPVVPLIELFALYNKARGGDLVSPLDVLNACTYMAAKMSSSCYDLVTLPSGRKALVNRDDSLLLAKLTTVLGPQLVNSKGSPVQDAWTKTSSQQQQRSGDASSLVRVSTTSDFPKASRDLKSVSDVSLAEKMQVATEVAADILTLLMLKGYLCCMDTGFDCYVYTWNIFVF
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.
Sequence:
MSNTNLSQLAADLMQDELQRENLPLEIFQELSNVISDWVNYDGQSNSEVDELTNCFRVLRNSCVNGARNQNEIMKLSIVSKTVQVLEKLSEQNTSTHHTVLLCGNQFLGNLIAGNLLNQQKLWKIIFPSYLKSILKVDSPKVLSAVVMTVYNCIGSTECFVDEIFQDESPTNIAISIIEKLPAVHDQDWVILCITEHFLKSEEFLPLIFNYGSISCKCSTLDVLSQYFETGDSIPPTHTATCLWNQFAKDCQDITAMQDHTNQTAMVTTKLLHTLCMATSSSAEARKSLSSCCAVEVVVDILRRVVMAGKLDKASVFAPAEKASPGAGAKEQCSPVAGFKRDLVRVIGNLCYRNPPLQNKVRELEGLPLILDSCNIDDNNPFIRQWAVFTIRNLCENNAENQAILSRLERHSVVENPIFQNSGLEVVESDDGHLSIKPST
The following text describes a protein:
Function:
Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
SERAVVLLSCVLSALGSGLLVATHALWPDLRSRARRLLLFLSLADLLSAASYFYGVLQDFAGPSWDCVLQGALSTFANTSSFFWTVAIALYLYLSIVRAARGPLTDRLLWAFHVVSWGVPLVITVAAVALKKIGYDASDVSVGWCWIDLEAKDHVLWMLLTGKLWEMLAYVLLPLLYLLVRKHINRAHTALSEYRPILSEEHRLPRHSSTADKKLVLIPLIFIGLRVWSTVRFVLTLCGSPAVQTPVLVVLHGIGNTFQGGANCIMFVLCTRAIRTRLFSLSCCCCSSQPPTKSPAGTPKAPAPSKPGEFQESQGTPGELPST
The following text describes a protein:
Function:
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.
Sequence:
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAHYPTVDTSPPELEAASVEQPFLAAGQSSNTASQRLGYHSGRRSYRDAFFLVLFLTALGATVGIGIYGILHRNRDFLDLVGKDSLNDPANCPAYHTDNVTLLNHLRSNEATLGALAKAFLTPVAVTLGASVVLGLILLWLLKTVPFFLVYATVSLVVLSPALGGLAAYSLARDDRQRDPQIVLYPAGATAVLAFVFWYIRDKLALTARLLGCSAAALRENLSLLTFVALVQVFAVVIWVPIPALIGVAYTDGRLAPNPDLKPGQACGANYDVTCCAWQPKSWFPAYAALAGVVALWLAALVNHIQSFTVAGVIAQWYFAELGHRRRAPICKNLRYAVGPSLGTLCLSSLVVTVISLVKDALENAKQKLRESGGENLLLSCVVCCFEAILSGIEFVTKFTIITVAITGDSFCSAAARTFVLLRRNLLSSVTVDSVSIWVLNLGTFVLSAAWGTAVGLFCSRQWSHHNAPGFDREDAGALGAVEGQVCFLVAFALLRLFSQLLLSVVDTVYICFALDKNQGDVTRRQVHEIYEKLPSVKKGRHGEDYEAAQGNGGQPYYASAPPVPGLPAHNATRGEPVTGYPLR
The following text describes a protein:
Function:
Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling.
Miscellaneous:
MISCELLANEOUS: Involved in non-canonical Wnt signaling only when massively overexpressed.
Domain:
The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Sequence:
MWAPSGQGPAGWDRRRVGARLRAALAGLQELQGLRATQQARVRGALGLHPAPGPRGQELRLEAALTALREQLSRLRRQDAGLKTHLDQLDQQISELQLDVSRSSCEALDSDSRPSSGFYELSDAGSCSLSTSCASVCSDRLSPSLGSWLPVFQPSKSRSGIGDWRPRSADETTVPAWSPQLTEDSRLLHGAEGTGRLTGMFRPRPVSTGDLERVLPADVGLQRAGTDAAHLLGQGIEIPAHALDPTYQRDLVARGGQEVYPYPSPLHAVALQSPLFALPKEAPCFDICSPPQEPPLVPVDENRTQPEPIRELGSAEAYIHRLLHLRGQELPLRDVGQEQGGDTAAFPPKPCGQRSESTCQLEKQACGADRGGLKLGRGAAKDSLKQHGPVSLVGAEPLSSPLKEETIPWNPCVHGDNTVGSSPCSQAQQPLNDCGQGPVLSPSRVLGTESPPLAPEPFAYTSCTTGETSPVKLRMGFSQNKAVKVRRRVSEKVPRLGKQLPPQPERQRVTERDPSRPHQGGLSRRPTLAREPPGRSCSESTLYPVPFLVPVVVAQRESYPTSPQAFFPMEAALLSSAARRKQRRWQSTMEISAKAGSVSQPGPSMGLPRSPAKRGSGPRAQSRPTLARQDACARCESDPSEHSADCTSLYHSTIAETSEDEEASDHTANRFGDESSSNDSEGCFRGSRRRLAIGSAEAGQGGWAWPRVPPQQPSRAPGNTRPPLPPVPKLCRIKASKALKKKIRRFQPAALKVMTMV
The following text describes a protein:
Function:
Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MGELSPLQRPLATEGTMKAQVLLKLALLALPLLLLLSTPPCAPQVSGIRGDALERFCLQQPLDCDDIYAQGYQSDGVYLIYPSGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWNDYKLGFGRADGEYWLGLQNMHLLTLKQKYELRVDLEDFENNTAYAKYADFSISPNAVSAEEDGYTLFVAGFEDGGAGDSLSYHSGQKFSTFDRDQDLFVQNCAALSSGAFWFRSCHFANLNGFYLGGSHLSYANGINWAQWKGFYYSLKRTEMKIRRA
The following text describes a protein:
Function:
Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mdl-1. Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging and may overlap with the insulin-like signaling pathway. Involved in promoting infection by the microsporidian pathogen N.parisii. Required for the expression of svh-2 and the promotion of axon regeneration after injury.
Subcellular Localization:
Nucleus.
Sequence:
MSDMSDLEDDQTGHCGSGEHSGPFDPKRHAREQHNALERRRRDNIKDMYTSLREVVPDANGERVQASRAVILKKAIESIEKGQSDSATLSVDVAEQESKNAKLREEIARLKAKKDPSSSQSIIQ
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits translation and colony formation. Its toxic effect on colony formation is neutralized by coexpression with cognate antitoxin VapB47; the effect on translation has not been tested but is probably neutralized also.
Sequence:
MIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVESMRVVARYGQPGQTERARYLLDGLDILPLTEPVIGLAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR
The following text describes a protein:
Function:
Required for the maintenance of the cell wall integrity.
Miscellaneous:
MISCELLANEOUS: Present with 8070 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
METLLHAKLLLSAEVESLKSGSFDQTYVKKAEHIISGESYQLVQQFVDKFKGKISISGEISTSSVIAALNDFLNVEVFKMGQENEMLFLAIALLQTFIQNNYTGPAARLKAISGLFGKTGIEIGAVNTALSRSLAIMGQPAYEFMDDPLYLVLSLLLLERITGQKSLFDVTPDQEIPLPIISAESTPGLLAVAYWWWARALLTQLSLIPEPSGFQASVASAIYQSADLAYAITKELPESIHEDFKRELCAMYYLENVKCSLAINTEHLCLPSLTRAKKITNFEFVMTGARATRTKYQQKAHAGLIILAKSFTFQNFALRTTSATPETFALESDLLLEKPHFESIADEPLDEQIYSKRQKVDLNEGYEEDKLLPLALRQENIPKLLLDLNPNDQPTLSDYDNIQLLLRLYTIKNTTPAKDPLVEEELTALLSRILYQNGDKNWSIFARSLWERSIIETTKAKTIERGLLQMQSLVEELDLKIKSKLVPSSSEINVASRLSYIHQLPFIPRWQLDATLAEKYMSLGILKSAVEIYERLGMACETALCYAAVGDEKKAEEILLQRINENDSDARAYSILGDIKQDPSLWEKSWEIGKYVNAKNSLAKYYFNPPPKSGAQPNYSATLKHLNDSLRQYPLSFETWYFYGCVGLQCGKMQIAAEAFTRCVSLDPYHALSWSNLSAAYTKMDKLKEAYSCLKRAISCDAQKNWKIWENYMLVAVKLNEWEDVLTACKQLVSIRRDKSGEGSIDLPIIEKLVELLVTSEYPEEPQQLSYFQKSCTEFICNTLPQVITTSARCWRLVARVELWRKRPWAALECHEKAYRAISHNPDLEVEEKVWNDTVDACEDLVAAYESLGEMEGKYGPGSLVCKDWKYKCRSTIKALMSKGKGRWDDSPGWDRLVEARSQI
The following text describes a protein:
Function:
Might play a role in signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression in early development as part of the Janus kinase-STAT pathway. Might play a role in male germline stem cell maintenance.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Sequence:
MSLWKRISSHVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHMLAAVKELMRVRLVTEEPELTHLLEQVQNAQKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYVNENGLVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVTGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNGDFGMADFDTITNFENF
The following text describes a protein:
Function:
Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling.
Subcellular Localization:
Secreted.
Sequence:
MLPPAIHLSLIPLLCILMKNCLAFKNDATEILYSHVVKPVSAHPSSNSTLNQARNGGRHFSSTGLDRNSRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESVSPAKPAQHHRERKRASKSSKHSLS
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAPRASLRLVAPVWNRGTSGIRGLSKAVDPEGSQKKGRTLLQFLTDHFYDVEAVREYLLRKQVLKVQKKNRSFTYIKERYGPYVAGAYFVLKQGGAVKFRDREWMRANEQGLSSLEFRKLQEVPVEAVDASGCAINYQGLDNLLALKELQSLSLRRCPHVDDWCLGRLYQLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPHCEVLGADWAQGLKVGPEEQSRDAASSPIPAWPSAPPHQARSLPGCAERPTAHPSGSVGLTQLGGSGWGEGRRA
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MEFRVNTEDDLRIVLLGKTGVGKSTTGNTILGRKAFTAETSHQPVTKESQRETCEINGRQVTVIDTPGVFDTELTEEEIQREIRHCISMILPGPHVFLLLVPLGRFTKEEETSVKIIQETFGENSLMFTMVLFTRGDFLGNKSIKEFLGKPGSPLMNLIEACGHRYHVFNNTQPEERTQVSDLLEKIDNMVKANGGSFYSCKMFREMEREKQEQQMKILMDRVRETEEEMKKLEEEKERMKMMMEEERQNQETERKRREEELKREIREGEEHQREMKEEMKRERETFRHEIEEIRREKEKMQIKHETETDRLMKRTEDEKKKRDEENTEREEKYTRQIREKEEKEREMKEKMKREREEMMKEIEKLQLKHQTETERLMKRIEDERQNHETERKRREEEFNEREERYKREIKERKQSEEKMCEEIKREREEWEKQRQEENNRREEEDEKRREKEQRDREELNEKLKEEKDRMEREKEDLQSKHEEEEKKMKIQIEELNREREELMKKHEEEKEKMKMMMEEEKKRREEELMKSHEEEKERIKKMMMMEEEQQKQEKEGKRREEEFREREERYKRLIKEREQKENELIEQMKLERMQKQKPEERLRREKEKQKSELHKRRQSPVRELTAGLNVVLLGKRGAGKTASGNTILGRQAFITEKSPKSVTRDVTVESGTFCEQPVTVYDTPGLSDIEMSEEEIQQMINEKVLQKCSSGLCVFLLVIRADRFTDDDRKTVEKIEKILGEKHQKNTWILFTGGDELEEENTRIQEFIEETEELKTLVQKYEHRYHLFNNKRKMKKDEEGLSEQVKILLTKILKPYTMGEEINPLKRKIPENIGAVSPVSSPPSRRIVLVGKSGVGKSAAGNTILGQREFRSAMSVFSVTFKCSAAQTTVSGRSVSVVDTPGFFNTQMKPEELMMEMARSVYISSPGPHAFLIVFPVNMRFTEYELQILQMIELMFGQEVLKYSIILFTHGDLLDGESVEELIEENSRLRSLVQQCGGRYHVFNNRDEENREQVEDLLQKIDSMIQQNGGGHYTNQMYEDAQRFRQEEEEERQREEEERQREEEERQREEEKRKRQEDKQIQEVIEREIKKTAERIKSEDQGRKQSENCVCS
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MWFEILPGAVIITTLLSVPIYAMYGLDKLMIGNAFRRNMDERFSRVMYQRDFRLTDNPYKMNGLEQIPDEEVKKEEKDPNEDSDDPAIVKKREKERKLREKQLKKEEKLREKQLKEEEKQKKN
The following text describes a protein:
Function:
Member of the two-component regulatory system RstB/RstA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTIVFVEDDAEVGSLIAAYLAKHDMQVTVEPRGDQAEETILRENPDLVLLDIMLPGKDGMTICRDLRAKWSGPIVLLTSLDSDMNHILALEMGACDYILKTTPPAVLLARLRLHLRQNEQATLTKGLQETSLTPYKALHFGTLTIDPINRVVTLANTEISLSTADFELLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLDNAAEPYRIKTVRNKGYLFAPHAWE
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MVRGKTEMRRIENATSRQVTFSKRRNGLLKKAFELSVLCDAQVGLVILSPRDKLYEFSTSSMQEIIERYQRHTKDIQCENPAMEQNNMQNLKHDTSSLMKKIELLEKSKRKLLGESLESCSLEGLQQMEHQLEWSINIIRARKMEVFSEQIERLKENVKDLASENVMLLEKCGGFEMQQTSGGEDVSMVISSEKSDVETELLIGLPMSLN
The following text describes a protein:
Function:
A probable mono(ADP-ribosyl)transferase; it is not known which residue is targeted for ADP-ribosylation. Upon expression in yeast cells causes cell death.
Subcellular Localization:
Secreted.
Sequence:
MKEIIRNLVRLDVRSDVDENSKKTQELVEKLPHEVLELYKNVGGEIYITDKRLTQHEELSDSSHKDMFIVSSEGKSFPLREHFVFAKGGKEPSLIIHAEDYASHLSSVEVYYELGKAIIRDTFPLNQKELGNPKFINAINEVNQQKEGKGVNAKADEDGRDLLFGKELKKNLEHGQLVDLDLISGNLSEFQHVFAKSFALYYEPHYKEALKSYAPALFNYMLELDQMRFKEISDDVKEKNKNVLDFKWYTRKAESWGVQTFKNWKENLTISEKDIITGYTGSKYDPINEYLRKYDGEIIPNIGGDLDKKSKKALEKIENQIKNLDAALQKSKITENLIVYRRVSELQFGKKYEDYNLRQNGIINEEKVMELESNFKGQTFIQHNYMSTSLVQDPHQSYSNDRYPILLEITIPEGVHGAYIADMSEYPGQYEMLINRGYTFKYDKFSIVKPTREEDKGKEYLKVNLSIYLGNLNREK
The following text describes a protein:
Function:
Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGAALGLEIVFVFFLALFLLHRYGDFKKQHRLVIIGTLLAWYLCFLIVFILPLDVSTTIYNRCRHAAANSSPPENTNVTGLDASVTPAPRQHPCFKPWSYIPDGIMPIFWRVVYWTSQFLTWILLPFMQSYARSGGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPRLHLEWNQLQTIGIAAANTWGLFLLVLLLGYGLVEIPRSYWNGAKRGYLLMKTYFKAAKLMTEKADAEENLEDVMEEVRKVNESIKYNHPLRKCVDTILKKCPTDYQEKMGRNMDDYEDFDEKRNTYPSEKSLVKLHKQVIYSVQRHRRTQVQWQILLEQAFYLEDVAKNETSATHQFVHTFQSPEPENRFIQYFYNPTVEWYWECLLRPWFHRTLAVVLSIFSVIVVWSECTFFSTTPVLSLFAVFIQLAERTYNYIYIEIACFLSIFFLSICVYSTVFRIRVFNYYYLASHHQTDAYSLLFSGMLFCRLTPPLCLNFLGLTHMDSSISHQNTQPTAYTSIMGSMKVLSFIADGFYIYYPMLVVILCIATYFSLGTRCLNLLGFQQFMGDNDMTSDLVDEGKELIRREKRKRQRQEEGENRRREWKERYGHNREDSTRNRNVHPDPKESNFSDTTTNWSSKYTRANNRTERDRIELLQDAEPLDFNAETFTDESLEPESGRYQPGGRYLSMSSSIIFEDI
The following text describes a protein:
Function:
Hydrolyzes 1,4-beta linked polysaccharide backbones of mannans. Has high activity toward locust bean gum. Also active toward konjac and beta-1,4-mannan. Hydrolyzes mannotetraose (M4) and mannopentaose (M5) to mannobiose (M2) and mannotriose (M3) with a little production of mannose (M1). Hydrolyzes beta-1,4-mannan to M2, M3 and M4. Hardly hydrolyzes M2 and M3. Does not hydrolyze p-nitrophenyl-beta-D-mannopyranoside, gua-gum, carboxymethyl cellulose, soluble starch or laminarin.
Subcellular Localization:
Secreted.
Sequence:
MVKLFSFLLLVWVASPAFSSEFLKASGSNFYYGGQKVFLSGVNFAWRSYGSDFGNGQYASNGPALKDWINKVKASGGNTARVWVHVEGQVSPAFDSHGFVTSTDSKKTLINDLSDLLDYANGQNVFLILVLFNGALQNNSNVQNLFWDESKLNSYINNALTPMVNALKSKPSLAAWEVLNEPEGTLQPGSDQNSCYDTSTLAAQGAGWGGKKFPMKQILKTINWISSAIHNADSKALVTVGSWSELTQTDSFGYRNHYKDSCLTGAGGKSNGIINFYQMHTYSHSGKWNQNAPFKVNRWAYNVNDKPLLIGEFASVCSQNEGIQNLYKYAYNNGYNGALTWQFNSGGDCSDTYSNQMYGMQALKGQNDQSGGKGGMVSVNIN
The following text describes a protein:
Function:
Glycosyltransferase; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA). UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U.maydis. UA consists of 15,16-dihydroxypalmitic or 2,15,16-trihydroxypalmitic acid, which is O-glycosidically linked to cellobiose at its terminal hydroxyl group. In addition, the cellobiose moiety is acetylated and acylated with a short-chain hydroxy fatty acid. UA biosynthesis starts with omega-hydroxylation of palmitic acid catalyzed by the cytochrome P450 monooxygenase cyp1. Terminal hydroxylation of palmitic acid precedes subterminal hydroxylation catalyzed by the cytochrome P450 monooxygenase cyp2. Sequential glucosylation of the hydroxy fatty acid is probably catalyzed by the glycosyltransferase ugt1 (Probable). The cellobiose lipid is further decorated by acetylation of the proximal glucose residue and by acylation with a short-chain beta-hydroxy fatty acid at the distal glucose residue (Probable). The acyltransferase uat1 may be a good candidate for catalyzing either acetylation or acylation of the cellobiose lipid (Probable). The fatty acid synthase fas2 may be involved in synthesis of the carbon backbone of the short-chain beta-hydroxy fatty acid esterified to the cellobiose disaccharide (Probable). The secreted UA consists of a mixture of both alpha-hydroxylated and non-hydroxylated glycolipids; therefore, alpha-hydroxylation of the long-chain fatty, catalyzed by the fatty acid hydroxylase ahd1, occurs late in UA biosynthesis and may be the last step before secretion.
Sequence:
MATEHILLVCWPAVGHARPMLDYAAAQLKQNPGLIITFICSKMQIALLEGLAISEHLADKKFGDRLRLLGTGRPAQEVLKEFGDREDAKNAANSASKAPNTTANGPEPEVILTMQAATLIQKRFAEIFPTILANDDLFDEQDNSLLLPACVAGKPTTIVVNWMLPGMVETVRKHSSDLKMVTFFDNSCTFVTRMLGPRSIGGFGGIERLWSQYCNSNPEVDPNDSTLKEKLLGRRWTGKFYIPGSRMGAIEEQEMAALAKDWLLSVPLTPSLIEIQKLVDASHTILINTHLAVEERELDYLRMVYPFKKIGILGPAMFSGFVEKGEKLAAKLLDKHINVKPAASRPLTPPETPPPGSPDTDSHGEEEDPKQKSVKQVEKFLAESATGSVVYISFGTMFRPQPTHLIKMLEIIIYEMSLSSQFRLLFTFGGSKDLASSCPPSFAPQISALESQLFKSGNTLFVNWVDQHYVLQHPSVGWFLSHGGWNSCQESMLAGTPLLILPFFGDQLFNAYFLESIQIAYRFNTAANMSVADFVASFREGITCTRPESERGSQLTKNAKELQLRLKGERALAEVRLF
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MSSTRKVTLKSSDGGTFKIDKAVALESQTLKHIIEDDCIHDNGNPLIKVTSNILAKVIEYCKKHVEAGSSEEKPLHDDLKATLLDLILSANYLNIKSLLDLTCQALGEMMTKTTPDEILKTFNSVNDYSPEEEEEARQENQWACE
The following text describes a protein:
Function:
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MLTILVLLYLGCAVTQCQKTCGYYNVTDALGVLQLSPTLVYLRPVTDWREPTYVTLDMTFRSVLQMDEKLQTLSSLMDIEMTWENQLLSWDSEEFCGISRVSIPESTIWIPDIYISETIEDNSLDVLYVHLYNNGTVQRTKTLNVMTTCTLDLYKFPFDEQKCNLTFGISTNPVKDVILASGLKAGNITLLSKATFTTGEWSLQNVKVFPLNISKNGETWSKMIYQISIKRAPMMYVINLIIPACLLVVVDVASMFIPMEGGERLGFKITVVLGFSVLLLILNDFLPNTDTPPILGVFCMVCLLIMIVSIIDSIFIAYMLHLSAVRPEVPHWLKLWVLKRLAFLVRIPTNERKLGSNILGHENTAVIEKAVSLPEQENSTSKQVSKEFKDSMEIKLLKKLLRELLLVRQHLIVTKQEEEDKSEWHMVAFVLDRFILILYLIIVTLIAVIMVSVWVA
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (By similarity); Inhibits translation of various mRNA species in vitro. Associates with a 35S prosome-like particle that contains non-translated mRNAs in a complex with proteins. May be involved in pre-translational regulation of some mRNA.
Subcellular Localization:
Cytoplasm. Lysosome. Cytoplasmic vesicle, autophagosome.
Sequence:
MATPLSQVRQNYHQDCEAAVNRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWENGLTAMECALHLEKNVNQSLLELHKLATEKNDPHLCDFIETHYLDEQVKAIKELGDHVTNLRKMGAPKYGMAEYLFDKHTLGHSDES
The following text describes a protein:
Function:
Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGNDISLIALLAFSTLLPFIIASGTCFVKFSIVFVMVRNALGLQQIPSNMTLNGVALLLSMFVMWPIMHDAYVYFEDEDVTFNDISSLSKHVDEGLDGYRDYLIKYSDRELVQFFENAQLKRQYGEETETVKRDKDEIEKPSIFALLPAYALSEIKSAFKIGFYLYLPFVVVDLVVSSVLLALGMMMMSPVTISTPIKLVLFVALDGWTLLSKGLILQYMDIAT
The following text describes a protein:
Function:
Putative sodium-dependent amino acid/proton antiporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MWQHSTDDDDCKDEETGSMASSIFNILNTIIGAGIIGIPYSFRLAGLGLGIIILTLVAIISDYGLIMLIKAGTITDENSYRGVMTAAFGKPGHVIALLTQFLYPFIALMGYCVVVGDIFTKVFRLFGDDGNLLTNRQFVISAAMLLIMGPLCYMKKISKLGWVKLIRFEFSFYIIVLCVYRYLESQSIQFAAPKVPQALAIMQFTFVCHYNIFIVYRFMKKKSEERISRACHTAVGISYLLCLVLGIAGYLTFLDATQADILQNYCVHDVLVNVARICYGISVMTIYPLDCFACREVSLFPDRPKSTLRRVVITTCVILGSLPVPLITSCLGTVLELNGSLTAAPIGFIFPAACYLKIAKGSLISPSKLAAGFIVVLGTFASFLGTIYAIIGAKGCGHHVLNPWCNETMFSNDSYITILNNTLK