lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Probably functions redundantly with other cyclins in regulation of cell cycle. Its presence may be required to delay a deadline for completing cytokinesis that is ordinary imposed by nuclear envelope reformation. Degradation of CycB and CycB3 promote cytokinesis furrow initiation and ingression. Required with CycB for female fertility.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Sequence:
MAPTKATTRAAITSGHHQLQQAVNPILGALGAATRKGLTRRAAATGNIDPNVENMQTRAKRKADHSPIKNDKIKRSALGNLTNNVKIMTLHPAQDEEQSGVGKKPTAQQLQALMDAKKQENLSVNVFGASKMTTRASSKVEDSVENCHKVLDKLEEALARPKPRPKAVPAAKKTVLGEVQLPAMPNPMQIPVLLPPTHNLAAPQVAAVKPVRRISNDFNKTEDSLYMSALEDVSSCDSMRLSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQVVPIPPVPEEVEDFDRKNWDDPFQVSHYAMDIFNYLKVREAEFPIADYMPRQIHLTTWMRTLLVDWMVEVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDGAYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLTLARYILELSLMDYANISFSDSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTGYQLADFAEIVTALNAGLHRKPRATIKTIRNKYSHKIFHEVAKVPLLTNQELFQGNLDLNESNLS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDYTDKSCVPSRDATLSVAMNVSKWSERLERCVWSFLLACGTFPLRFDAVGPGRFFTSRKCALYCSGITVVYAVLSPALMYLIYEHERVANVYLVSMLNAAQLSFIYLFMIVVNVRMLSKAQRLASTLNALLAIRNTILQQWNCRVLSREYGQLLLYKVLAIDMALLLFSLIMYYVTQDEVPTGAEVVVGVTFSVFRYVFTALVNLYLVGLMIVSFNQGSINSKLTSLVDRSGEEKPSTIREVYMVHCENAQLEKQFMAIMDLPVLLLNGWYFYMIVVSVYYMYTSTMVEVRRGFGVEDVTKYFNSVTFFLYLAVQLYYMMSIPSQYTERSKKMLSILGAINHRSRGRRMERMLDFITLDYMQRDYDVRNYGLYDINRALLFGTIATVTSYVIILVQFHMQQYG
The following text describes a protein:
Function:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Sequence:
MKSAFLIWFQVAGKRDPEQEKEAQAWIEAVIGERFPPVPYEIALRDGIILCKLMNRLCPGIISKINTSGGDYKMMDNLSQFQKACVRYGVPDVDLFQSTDLWDQKNIAAVTITIFAIGRTAYKHPEWKGPWLGPRPSEENKREFTEQQLRAGEAIIGLQAGTNKGATQAGQNFGASRKIILGK
The following text describes a protein:
Function:
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MFTELKRYSILSLYTCALFFSVPLSLLIWFVRRELCTETSVAGEKQSKTRRSLTQSTNRAQMSSSTLNNNIAIKKMHVVIVHPEQWNGGSDRCTVALIRHFVSQGHRVTWLTTMIDEYWKNHTFDGVEIREVGLKLHPGDWWSQNVALGWHMVFSNLNPDVAIIDHSASCVPMIKWRFPQCKILFYCHFPQQLVTPSRFFLYRWYAKLIGIVEEELFGQIDQIFVNSNFTATQFCKVMPNIEKSKVRVVYPPCDIDFIVTASEKPVSRAERAKNNVYTFLSMNRFWPEKRLDIIVEAAAILKRRGYTNLHVQLAGSVMPHIPESRIYYDLLQDITKELDVTDMVTFIPSPTDKVKFQLYQQCDTALYTPPNEHFGIVPIEALDQRRPVIVCDSGGPAETVLEDITGTKIAKPCGELLADAMLHHMNKTDWPELDTEEGYAKQGGDDVSKKKNILVIDSRIRMIQMYGGSVLKPNSPHMMGDLAINSEESSLEPVETIVHQPVATETFAKPYQQKNAAHIRRAQA
The following text describes a protein:
Function:
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Sequence:
MWGQYKYTALSMGLDEGHLPQSHKSVPSDTWLMWCCHTAISCLSLLFLIVTFPLSAWCFLKMVPDYQRIVIFRLGRVQAARGPGLVLLFPLIDQFQRVDMRTKAFSVPPSKVKSRDGVLVSMGADIQFCICDPVLSVLSVQDLNFVTRNTAQNLMTQSLGRKYLREIQNDRARIAEHLKEDLNEQVKPWGLCVERVELALESILQTPENALIVPSVTPAVPCGGIDQLLMQFLALTRQSSGNDSPSLKDTDLSLKQLLSKVEASLTESLVSEVGSSYQLYVTMPGGQISEYFLDLKSGSGNCGWGVHPCPDVTLEMTEADLMSLICGDLHPLTAYTGGRLRVSGNIQTALQLERVLRAAWQ
The following text describes a protein:
Function:
Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MKRATNLLLVPRRIQNLRFLSEKAAGNLAMEPGKKTTHFGFTDVDEEEKEKKVHHVFANVAKKYDLMNDAMSMGVHRLWKDYYVGGLQIPYNAKILDMAGGTGDIAFRLLRHSPTAKVTVSDINQPMLDINPSRLKWICANAEQMPFESNTYDLFTMSFGIRNCTHPQKVIAEAFRILKPGGQLAILEFSQVNAALKPIYDAYSFNVIPVLGEILASDRQSYQYLVESIRKFPNQDEFARIIREEGFERVTYENMTFGVCSIHKGTKPRK
The following text describes a protein:
Function:
G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter. Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MDSGLSPSADLLHFNTNSCVNYSNTWRGLPHGDTLRHNHTLTLHDHLHNALLGVFLGLLSLLTVIMNLLVLYAVKKEKSLHTVGNLYIVSLSVADLIVGATVMPLNLVYLLEDEWRLGRTVCQFWLIMDYVASTASIFSLFILCLDRYRSVRQPLKYLKYRTRGKASVMICGAWLLSMTWIIPILGWRSFTHVDLKPEEESRCDTDFRFVTWFKVITAVFNFYVPSIMMVWFYTHIYLAVRQHLRDRERIIHPTDSFGEIENGENVPCPEGQKSKSPKTDIEDSIKRLKREKLLDQNTIEQTYSLEDSDKTKAAPFRAPRKIGVKCQQTSLLSMTTKRLRMVHKDKRPLEERHPCAETSLSPPSAPQDGTCSGGNPESKLQTSLNECHVTVPNSVSRVCDISQVSDMQRYSDVLYNSFDPSQALPWPEEGVDDAKIDPENGVTLRQAWHRFIDQSRHRIQSLRIHKEHKAAKQLGFIIAAFLLCWIPYFIAFMVMAFCKQCVHHDLHMFTIWLGYFNSTLNPFIYPLCNGNFKRVFKNIMKIHF
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular Localization:
Nucleus.
Sequence:
MPKYYCDYCDKYLTHDSPSVRKSHTVGKQHKLAVQLFYQQFEAEFTQSLIEARLKEYEESKGRLIHQPPMGIIPTPYGQMYQQQQQQQQQQGILPFQGMQPPPHQQQGMVLSPGMPIHKMQPHQFNNNNNPHQQHSFQPPHHQHHPHQQHQQHQQHQHQHQHQQQHNQPTIPGL
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization.
Sequence:
MDEDAPVDESNEGIIGCLPSAVNIHHIEEIKELVDQLPIIFKLENECDETAAEVNYLRYSRLLHLYQEQPRLLDKWIPEIVANLVDLVTLIGIDVSKPRAMTPLSRESLKYLSDLCIVRGSKTIVRLLPHQVHLLDPLLQTLEYYETSQLSDHNQRNVLLMWLWIVVKNPFDLRRFDPTGDPDNVITRIMNVALHYMKWDWNSSQASAALVIAHCLSRTDGIPKVLSFLSRLLDSIKTHHENKKLLLADLILLLAILKHVDRRVLTGHIGTIHEQLSFLYPIDEKKGGLICKCLVKVVQRIGLIALKPRTCSWSYNRGKRLLEGMLDDNEEYSDEPSFSNKVNSNQSCNNEIDKENQWNDGDELENSEIVEFALMHVLEALSHSDTAVRWSAAKGVGRITVRLPNFDLATQVVGSIISSHFGEVAEYSSWHSHGACLALAELAHRGVLLPSLLEDIVPALELSLVFEDVMGRHQNGNQVRDAACYAVWALSRTYEPSMMAPYLQRLASALLCGALFDRQVNLRRAASAALQEMVGRQKNVSHGIPLIQSVDYFAVTNRQKCYEHLCVPVAEYSTYSAIILRHLITKKVVHWDEKIREQAAISLEKISEIRLENVSDDYYMEILDDFLKASCETRISPFLRHGYLLASGHLIKGLTSRGMDFSSKQTEIAWIPHILWPFCDMTTQPGALIRRTLCKFIQLVSASKKVLLLEKDKSEWLDVLLQLITDPREIIRSLAKTAVGEFVMTYLMNDEELIQKVKTRVIAAMTKCSDESERIGMGMICESLNSEAVDYEMFESLCNTILTPTSSDAKWALARQQTVFALNRISVNSSTETFNRIGQKCFETLYKAMTDYTTSANGDIGRFVREASMRAMSTILVDAKTEPPFLDEHVIKSAKYMVQQSAERISRTRECACACLKSLVKCEITGRCLPHIDLLMNIYSEPMDFISDRTVFQLKPLLDLGSEYYEQLILGIVVSAGGLAEGTQKTAKQLLLDHQREICENKPRFDHFLSTCADLFQRARKVNRIGNSFMQILPQIFGNLGIYEQCPETSESIIEMVDTMKTIAVRSSMMSRQRLSIDSLGELLNCGKKSTVYRSALTMILDTLNSQQPVLRKSAAERLYEHLCCAEESDDEVLEVLATTNWQDENDNVLKQAVAGISEKLIF
The following text describes a protein:
Function:
Putative phospholipase.
Subcellular Localization:
Secreted.
Sequence:
MTRLIRSKKQFLIRSLHSVFYYLGSLLHSTFEMNVFIGLLLATVVASQSSEGRDESYTYKQLCIVDDKPQVLDGFDCRNQVAVARWQNAVNTTGWTFLEVETKENYCPQLQAYSAGYLEGLLSKTVLTYHLKNAQEDYCKNFTGYCSRLSDFLTENQKWIQSSLETVAPDDLYWGAVNRTYHQVSGLIDAYEGREFKPRITYELHPILYLNLNGDFYDLEKKLNKTRDPAFEQTGGKCSGLIKVAPGNADLFISQVTMSGFQNMLRVIKLYKFGYDRQFYPGYASSFSSYPGLLYSSDDFALQTSGLAVIETTISVFNTSLFENTKPVGQLPTWIRAIVSNQLARDAREWCKLYSLYNSGTYNNQWAVLDYKKFKPNQPLPKNGLFYVLEQMPGKIVYSDLTWFVEKYSYFPSYNIPFFKEITEISGFIGQAAKMGDWFKWGASPRAKIFERDHGNVHDLDSLTALMRYNDYKNDEFSKCKCNPPYSAEAGISARGDLNPANGTYEFPGQGHVNHGALDYKGTNVELMKKLQFVAQGGPTWGKVPSFKWSEFDFKDKVNHVGHPDEWKFNTLVHKWETEINA
The following text describes a protein:
Function:
Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.
Subcellular Localization:
Nucleus.
Sequence:
MNEMENTDPVLQDDLVSKYERELSTEQEEDTPVILTQLNEDGTTSNYFDKRKLKIAPRSTLQFKVGPPFELVRDYCPVVESHTGRTLDLRIIPRIDRGFDHIDEEWVGYKRNYFTLVSTFETANCDLDTFLKSSFDLLVEDSSVESRLRVQYFAIKIKAKNDDDDTEINLVQHTAKRDKGPQFCPSVCPLVPSPLPKHQIIREASNVRNITKMKKYDSTFYLHRDHVNYEEYGVDSLLFSYPEDSIQKVARYERVQFASSISVKKPSQQNKHFSLHVILGAVVDPDTFHGENPGIPYDELALKNGSKGMFVYLQEMKTPPLIIRGRSPSNYASSQRITVRTPSSVNSSQNSTKRKMPSMAQPLNESCLNARPSKRRSKVALGAPNSGASISPIKSRQSTPMEASKENEDPFFRPNKRVETLEHIQNKLGALKNQCPDSSLKYPSSSSRGMEGCLEKEDLVYSSSFSVNMKQIELKPARSFEHENIFKVGSLAFKKINELPHENYDITIEKKSMEQNYLRPEIGSRSECKTSYGNELSLSNISFSILPNSAENFHLETALFPATEEDVPRTFSRILETGSFQNYYQKMDAENADRVYSKGVKLIASGTLPSGIFNREELFEEDSFYKY
The following text describes a protein:
Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted; [Tumor necrosis factor-binding protein 2]: Secreted.
Sequence:
MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
The following text describes a protein:
Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular Localization:
Secreted.
Sequence:
MLGLYEKLFVTAVALVVLAVVSSSPLVGPEPIRCAPCTQQKLNDCPAVPADCRQVLREPGCGCCMACALEKGASCGVHTASCARGLRCTPRSGEARPLHALTRGQGICTEDEGQEEADGVSDQGSLHYLFGMNLPSEYQDLAEGHESIKAKVNAIRGKLVQQGPCHIELHGALDMIASSQQELGDKFTTFYLPNCDKHGFYKAKQCESSLVGPPARCWCVSSWNGKKLPGSSDLLGDADCQQEVTQ
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Its toxic effect is neutralized by coexpression with cognate antitoxin RelB3 but no other ParD or RelB antitoxin.
Sequence:
MKSVELGPRARRDLTKLRRWLLNRAPSAADRAIDLILSRAEQLAQHSDLGRRKSQNMRELYVSFGAHGYVLQYRVYPDAVVIARIRHSLERR
The following text describes a protein:
Function:
May be involved in herbivory-mediated responses. May play a role in herbivory-associated molecular pattern (HAMP) recognition. May function is jasmonate (JA) signaling in response to HAMP. May play a role in defense response against the pathogens Altenaria brassicicola and Pseudomonas syringae.
Miscellaneous:
MISCELLANEOUS: Transcriptionally regulated by NAI1, a transcription activator which mediates the formation of endoplasmic reticulum bodies (ER bodies). ER bodies are rod-shaped ER-derived structures produced by plants of the Brassicales order.
Subcellular Localization:
Vacuole. Endoplasmic reticulum. Note=Localized in endoplasmic reticulum bodies (ER bodies).
Sequence:
MAMSHVQPMLLLLVSLFFLPALRGAIDFEYCAKNGNDYGTVTSIVVSPSVGPHENPTITINLFGSASKNIPAGTLVYVAFRDGEFTGLLKTYNLCDVSACNNEAEIEAGTNFELTLSDVLYVGYDEEIKYSVSLRRKTLEEEDPIIKMCVDFKVPAPAPAFVSI
The following text describes a protein:
Function:
May mediate the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNALRGLLNKYTGNQIVFSNKYATTFFEKFPKLAFLNNVTNLAPMMKWSLSIVPITQILSGTKLPENIDVYQASSLCATGSIWTYYATLISPQNTGTRMLAACNAAMAACHGYNIYRRTKWEKSQIIPIENKN
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(3) position of a uridine in 25S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKKARFKEARRLQKRNLNNAIGSSSINSQNSLTNDKIGKGKNKGPTERYVLPFEKNNRFLLLGEGNFSFAFSLLLHHVSSEGFVLATSYDSKEDLKQKYPDAAEYISKIEINGGKVMHEIDATKLHLHKKLKTQKFDTIFWNFPHSGKGIKDQDRNILDNQKMLLAFFKASKFLLSEKGVIVITLAETKPYTLWNLKGLAKDAGYTSLMTEKFDSSFYPEYSHRRTIGWIDGISERSPWKGELRDSRHYCFVVNGSNIKPYNQRKEKRKRSELSDDSSDSS
The following text describes a protein:
Function:
Has a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MYNQRQGNTATPPLHHPIPQHPIPPMRSPPVEQTQHQNLQDRYAPPQQHAQHQQHPQHGAGGDQGNFFNPAGYPQFFNDGTAQVGLQVGRSAVAAGQEYMEKNFNKYVSVSQLRYYFQVSNLYVVKKLGLVLFPFLHKPWTRDVVRSETTGEIEGYAPARDDINAPDMYIPTMAFTTYIILCSVLSGVHDHFHPQLFGTLASKAVSVMVFELLVLRLATYLLSADSQLFDFAAYAGYKLVGVLITILAASLTGSTYVKWGVFLYTYIANAMFLLRSIKYLIIPDGTSPVPQGINTGNRRSSIQFLAVYAFLFQLGMMWILIPANSVLNSAPVPVIAQTMS
The following text describes a protein:
Function:
Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function.
Subcellular Localization:
Mitochondrion.
Sequence:
MRALLPLLSVGRGWRVGAAARPPRRVMSLYRTEELGHPRSQDYRLFFKHVAGHYISPFHDIPLKADCKEEHDIPRKKARNDEYENLFNMVVEIPRWTNAKMEIATEEPLNPIKQDIKNGKLRYTPNIFPHKGYIWNYGALPQTWEDPHLRDKSTDCCGDNDPIDVCEIGSKVLSRGDVVHVKILGTLALIDQSETDWKIIAINVNDPEAEKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENKFAFNGEFKNKAFALDVINSAHERWKEMVMKKCDKGAISCVNVHICDSPFHCTMEEARSLVESVPTPSMNKESNVEEEVWHFLRN
The following text describes a protein:
Function:
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Inserts one or 2 nucleotide(s) opposite the lesion. During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase PolZ1/DNApol-zeta to initiate repair synthesis that is completed by end joining or another polymerase that can bind and reinitiate synthesis. Particularly important for the repair of UV-induced pyrimidine dimers and for hydroxyurea (HU)-induced DNA damage. Although inserts the correct base, may cause base transitions and transversions depending upon the context (By similarity). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue (By similarity). This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (By similarity).
Subcellular Localization:
Nucleus. Note=Localizes to interphase nuclei but undetectable during mitosis.
Domain:
The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
Sequence:
MSSARSHVSMQNKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRGDEAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSLPVGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEVASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESALNNAIKFLGISVGKFETVSSGQNKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTEDELKPSTSKRKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVKSLQTHRDHHFAQELSRTLRSTEREERTQSRQKISLKPTPPKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQEQAPSDPQMNQCPECKAFIKCVDMPEHLDYHVARNLQRELNQQDLRTRTAALNKEKISPVQPKKQSQKKLNSTISASSSGTKTIAQFFSQSN
The following text describes a protein:
Function:
Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MAPTTLLIVESLETLFGHHASQKSQNCCSQGRHSKFFHVDRPEIVEITGFRLGRAYHETCVLKENKSGRCTKEGAVVSASKLKTNAKTPETPLQPVDIGSVFGNKPIQRSKEIPEKRKRTVIEDHSDEDFEATLQQLDEAPVTKKSKVVEKSTSKKGKTDSPTKKEKMKSPAKEEKSKPALHLKMRKHLQKSQPGWNEEKDKRIKSQLKELDSNSNKTSSTPKSNKKMKAETTIVKETPKKKSSKDDDDDDPDVIDSPAFDALEKRKEKAENYRKFLASRRDGGAKNPGSKPVPEGAPGCLTGLTIVVTGVLESLHREEAEGLVKKYGGKAPKAVSKNTSYLLAGDDAGPSKLSKAKDLNVPMLSEDDFLKLIATRPAGQGLSSPAAKKAPTTPRSAHKAAASRKAEPEPPSKPITVSSPPKKKSPEPKKIDLKPQQSSSTAAPIRKAEPISVKMEVAEGNDQAQLPWVDKYKPTSLKQVIGMHGDRSIAKKLVYWLKSWYDNRGKKLAKPSPWSTNDDGAFFKAALLSGPPGIGKTTTAHLAAKELGYDLVEMNASDTRSKRLLHEHVMELLSSQSLSSYAHGSAQIEGGRKRVLVMDEVDGMAGNEDRGGIQELIAMIKTSKIPVVCICNDRQHPKIRSLSNYCYDLKFTKPKIEQVRGAMMSICFKEGLSLKPEALDEIIMGANQDVRQVLHHLSMLASGKKSLSTESAKLEASKSKKDLKLGPWDVVKKVFSAEEHKGMSIHDKTGLFFQDYSFGPLFVQENYPCVVPQAAKGNAIKTLDLLGRTAHCMSQTDLIEKVIRSQNAWSLLPVEAVFASVVPGQLMEGFISSQIVFPSWLGKNSRTNKMDRLLQELQTHMRLKISGSKRAVNLDYLPYVLNSIVGPLKRSGADGVSEAIRAMESYDLMREDLDSLLEVAQWPHKPDIMAGIEGKVKAAFTRAYNKEAHMTPYAAGQVKKGRSKDTADDLEALDGDEDGLAGEEDDEEQSQDPSLDAMIKVKKESKKTASSSSSSGATAAASRKKTGAPAATRGRGRGGRKKAAE
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.
Subcellular Localization:
Nucleus.
Sequence:
MADYWKSQPKKFCDYCKCWIADNKPSIDFHERGKNHKENVAKKISEIKKKSLEKAKEEEKMSKEFAAMEEAAMKAYQEDLKRLGAKAESTGQSSTPKKQEVKKGKKEKKKKQIAEISSETNEWVRGFSAEGYVYYYNTLSGESQWEKPEGFQDSTEESQTWIEGTSDDGLTYYYNTETGASTWEKPDGFVSHSKETNENKCLSNNSLEIESESANAKEGNENELQKPKQNFQKKPKGDDKVEKKPRKPKKSPYGDWQQVKQESIDEEDAAPPLLKPSHAASQTTKPYGEWEEIKEEEDPYEKVDLELPDTEHDPPAAPVLEKPEDAKMIFKEKTVTSLGDTAEGVPVFKKRKFENGKSRNIRQRQSDH
The following text describes a protein:
Function:
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MMRGCHICKLPGRVMGIRVLRFSLVVILVLLLVAGALTNLLPNIKEDKMLTLRREIKSPSKSALDSFTLIMQTYNRTDLLLRLLNHYQAVPSLHKVIVVWNNVGEKGPEELWNSLGPHPIPVIFKPQTANKMRNRLQVFPEVETNAVLMVDDDTLISAQDLVFAFSIWQQFPDQIIGFVPRKHVSTSSGIYSYGGFELQTPGPGNGDQYSMVLIGASFFNSKYLELFQKQPAAVHALIDETQNCDDIAMNFLVTRHTGKPSGIFVKPINMVNLEKETNGYSGMWHRAEHFLQRSYCINKLVNIYDGMPLKYSNIMISQFGFPYANHKSKM
The following text describes a protein:
Function:
Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Required for gastrulation, axial elongation and development of the craniofacial skeleton and eye.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm. Nucleus. Cell membrane.
Domain:
ARM repeats 1 to 5 mediate interaction with cadherins.
Sequence:
MDEPESESPASILASVRAQEAQFELLSRALEEERRHVTAQLDRVWVTPQEPPLANGSLTRRQQDGLPFLYTPTRMEAHSVHADERYVIDDSSYKSCTLTDESRCSEIPIQTVVGYSQTLDRPYREAAGSGGAYTTVPRNYHFRGPGVDSTMPLISQSPHPGYSSLSRPNQRYRSVDPFRGPGYGPQPQVRGGGLGGSQSDLLSGRIYGSEDAYGLEDDRRSLGGFIDGPDYATTGRRGANGGDPRRRLRSYEDPLSDHFGSIPTSGSLSSLGPAPLTLAPNSGPWRHPELPEVLAMLSYTLDAVRLNAAAYLQHLSYRNEDVKREVCRLRGIPPLISLLEDPRAPIRLAACGALKNLSYGPARENKMAVKNCDGVPALARLLRRRGEGIEGRELAECVTGTLWNLSSLDSVKMELVDQALYTLTQEILVPHSGWQQDGGMQDRVEGKPRHVEWEPALVNTTGCLRNISSERSEARRKMRECEGLVDSVVHILRSEVSHGLVDSKLLENVVCLLRNISYHVHREIPHAEKYMESPQNASAETQNPSCFGVRRGKGKKASEEAVDTVDFPKQTMPAQGYDLLFQPEIVRLYISLVKSSHTPAVLEASAGAIQNLCAGNWVYGRCIRAAVRQEKGLSSLADHLTHESERVVRAICGALRNLCGDNRNRELIGKHALNSLVARLSSSSAQSSALSEDTNVCVINTIHEVISGNLEAAKRLRESQGIERLVLINKGGGRSEREIRAAGFCLQTIWGYKELRRPLEKDGWKKSDFQVSTAATSSVQGYDDSTLPLIDRNLKNEKKSVNADIPLNDFIADQFTHNGDSSNRLPTRSDELSELDPLKECSVSAGGSLNLGDAEDQRV
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.
Sequence:
MAAVTDVQRLQARVEELERWVYGPGGSRGSRKVADGLVKVQVALGNIASKRERVKVLYKKIEDLIKYLDPEYIDRIALPDASKLQFILAEEQFILSQVALLEQVEALVPMLDSTHIKAVPEHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAAKQVKPVEE
The following text describes a protein:
Function:
Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.
Sequence:
MMKKRASHHLVICTLIDTLRFRLSSRKAISMNAFNKLVKHSKKISNFNHLSSIVGWDQAAVMPSGGAEARSQAMAELSVHIHGLMTQPQLADWFAEAESETLNIEQQATLREMKRQWQQATVLPEALVEAQSLAGSKCEHAWRSQRKNNDWTGFEKNWAEVVKLSQEEAQIRAEATGKTPYDAMLELYEPGTTTEQLNRVFSDVKTWLPSLIDVVIEKQSSESFIAPKGHYPAESQKALGLDVMKLLQFDFNHGRLDESVHPFCGGVPSDVRITTRYNESEFVQSLMGIVHETGHARYEQGLPKHLAGTPAGEARSMGIHESQSLFFEMQVGRSPAFIAHLAELAGKHFSAMNDPVFRVENIQKLYTRVQKDFIRVDADELTYPAHVILRFEIERDLMNGKIKHTDVPELWDQKMQAYLGLSTKGNDQNGCMQDIHWTDGSFGYFPSYTLGAMYAAQFMAAMKKTVDVDGAIRRGDLSPIFTWLSENIWSKGSLFSTDELVKQATGETLNPEHFKAHLSQRYLK