lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane.
Domain:
The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins; The cytoplasmic N-terminus preceding the first transmembrane (residues 1-22) regulates volume-regulated anion channel (VRAC) conductance, ion permeability and inactivation gating.
Sequence:
MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSNTIQSGPEDSLVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE
The following text describes a protein:
Function:
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDFFALLLAKFTWAWRRWEHQGKESTELSRGQDNFFAIVFIGGMLNKFSGESAFALISLLGASIMPHNFYLHSSIVQILNCDYKTNVMGTLNMLGLARRVGAKFLLTSTSEVYGDPLEHPQKETYWGHHLGVSSCYDEGKRTAETLTMDYHRGANVEEMKISLFRNKFNIKVRNQQSFQGELCVRTIFLPLFSYSAANVSYSTGLLLLTFPDTLSLLDQVFRSSVAPFTIMLVTFISNQVTPLTWDLGRQAVVHYLEWHPRLVSLCDDQRAEGLYQLLILTQVVVALVLPSSVIPLFRLMEFLSLGTFIGLFVIEMIFGNSDWYWGSSVSTPYVFLLIAASLISLSHAVVSSYSTEICKFQVRCSGILQTPMPEPYLECNQLEGSSQKQEGAFHVEKSLVSHPYLSTKDPDQLLPESLLNFEKVHHLATIDEGKSETTYSAPAVGHPEVSVSAGASSANDRDDGDSWEEPEEAIRENTQSFISDGPGSYKSLSEKLEDTGIVTGSLPRLAEVLNEFWWQLFGYHGMHGHSRSEVQKTGYNTWSGLIGESKTCPSITKSGKQWVYSIGECKDTRVSDQLAYVLPQVAICIKHCGLIFDIFYMV
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MLSNTLRSNFLKFYANRNHTPVASSPVFPHNDPSILFTNAGMNQFKNIFLGKEQTSYTRATTSQKCIRAGGKHNDLENVGHTSRHLTFFEMLGNFSFGDYFKQDAISFAWEVSLSIFNFDPDFIYATVHEKDDEAFALWEKYLPTDRIFRLTDKDNFWSMADTGPCGFCSELLFDRGEKFGKAASPLEDVDGERFLEYWNLVFMEFNRTSDGTLLALQKKCVDTGAGLERLVSLLAETETVFEADVLRHLISKIENLSGTTYSPTEAKGAAFRVIADHIRSLSFAIADGLLPGNTERGYVLRKILRRAVNYGKRLGFNRPFLADVVPSLVDVMGEAYPELSASVTQIQEVLTTEEEHFFKTLQRGGNLLQQVLKSSASSAKISGEDAFKLKDTYGLPIDEIALLAKDYNYAIDMDTFEKLEVEAKERSRKNTKKTKNDSDSVFQDLDPTNTSEFIGYDTLSCDTFIEGIIKYNEIASSLEEGDEGAIILRTTPFYAGKGGQIGDSGEIFCESGTFLVSHTIAPKAGLIVHLGKLSQGSLTTTMAVTAQVNQNLRKKTANNHTGCHLLHKALEMTLGEHIRQAGSYVDSQKIRLDFTHNKALSPEDLLAIETLVNEKIRENDPVTIREVLYSDVMSSSEIKQFFGDKYGDIVRVVSAGFSHELCGGTHAQATGDIGYFRITKEHAVATGIRRIEATTGEDAENIAREQDVDLNEIATVIQSPKDQILVKIRSVMEEKKDLAKQVADLENQLVQQQVKTLLTSCEKICDTSYLVYYLTEEEGQRIQHYANAIHKEIPTNFISLWITEKNGRYIVLSRVSDDLTKRGVQAHTLLAELLAPYGGRCGGKAISAQGSSAELPQIEFLNKTLRQWISTQLA
The following text describes a protein:
Function:
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.
Miscellaneous:
MISCELLANEOUS: The name 'dim gamma-tubulin 3' derives from the decreased gamma-tubulin staining of the spindle pole seen following RNAi-mediated knockdown of dgt3 in S2 cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MGDLLSNSEFFKKLGVDSSNQWILYDEQMEMFFKFLSGNITDANILTERQVLEREEMQRRGEWLSASDRELKLLQIEAESPGLLNYKQQDVDALTMSIEAIEDASRDYATLLEDMMTTKHSITKHLGEVECVTAELQLREKDLIAECQSKAKQLEELQQENCRLSAEAKKAFTAPQLPPLFMHQLPLEQYFHKCDSFMQYFTLYVKENFKIQDYDEFQSAEEDLGREKAKLEDLERGIQFYALSYIRTKAKVKATQCLIDQLDLGKIHCLSLTDMAREMHDLQLLNDYQLSNTHDTLLNDLTIHIQQHTQRRIELVLYENTKLKLERAVRRHESDKKLTKIISDALSNAELLWIAIQLDCDKKRNCLDTSEELRDQAQATWQRIQTMRSINASYQGICAQFVQEIANLLSAHLGQNIKATEAKACLFEYEKFGRLLSYSFQSMLNRKSCAAVQDQLAELKRLEQTLRPFVYDSPLEQPMFENVRYLSAIYNVTQQQTRLDESGRSLRKDFLENVVGRIERDKLYRYSVVLWIWFLTEPQRMMHAIDEVKKAAAAVIRPGGGLHRK
The following text describes a protein:
Function:
Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has replication fork regression activity, unwinds stalled or blocked replication forks to make a HJ that can be resolved. Has a DNA unwinding activity characteristic of a DNA helicase with 3'-5' polarity (By similarity). Involved in genome maintenance but probably not in phase variation, which contributes to virulence and disease.
Domain:
The wedge domain within the N-terminus inserts into the replication fork junction, where the lagging and leading strand split (By similarity).
Sequence:
MSLELLDAVPLTSLSGVGAAISNKLAKIGIHNLQDLLFHLPIRYEDRTRITLIANLRPEQYFTIEGIVQTCEVAFGRRPILSVSLSDGTSKIMLRFFNFNAGMRNSFQVGVRVKAFGEVKRGRHMPEIHHPEYQIVRDNAPIVLEETLTPIYSTTEGLKQNSLRKLTDQALALLDKVQIAEILPNEFNPHQYSLKEALRLLHRPPPDISLEMLEQGKHPAQQRLIFEELLAHNLAMQKVRLGTQQFSALPLHYQTDLKQRFLATLPFQPTNAQKRVVSDIEQDLIKDYPMMRLVQGDVGSGKTLVAALAALTAIDNGKQVALMAPTEILAEQHANNFRRWFKPFGIEVGWLAGKVKGKSRQAELEKIKTGAVQMVVGTHALFQEEVEFSDLALVIIDEQHRFGVHQRLMLREKGEKAGFYPHQLIMTATPIPRTLAMTVYADLDTSIIDELPPGRTPITTVVVSEERRAEIVMRVKNACVNEKRQAYWVCTLIDESEVLEAQAAEAIWEDLTKALPMLNIGLVHGRMKPQEKQDVMMRFKNAELDLLVATTVIEVGVDVPNASLMIIENAERLGLSQLHQLRGRVGRGCTASFCVLMYKPPLGKVSQKRLQVLRDSQDGFVISEKDLEIRGPGEVLGTKQTGIAELRVANLMRDRKMIPTVQHYAKSLIQKYPDVAESLIRRWLNNKEIYSNA
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Subcellular Localization:
Nucleus.
Sequence:
MIIEDFEALKHWLSKTLEPICDADPSALAKYVLALVKKDKTDRELKALCIDQLDVFLQKETQGFVDKLFDAINTKNYLPQPDSTSTAVVKLDTFEHQEREIKKDEVNKEEEKEKKAPRRLNQSPQPSITRHKETRENRKRSNSDRESSSIQNSFRSGLPEQKLDVDAAPTRLSSNKVQNAKNIRSRDDRKREDRFRKREYDRNVPRRDLYRDRYNRRRGRSRSYSRSRSRSWSKERQRDRERDRSRSRTRSRDKDSGKPKFDLDRSDPVDNSYASGSSVSHIGPAHFPVPTLSSTITVITPSHHGNSSAENWPEFHEDQVDHSNYGRPQIPKKRCRDYDEKGFCMRGDMCPFDHGSDPVVVEDVNLPGILPFPAQPPAVEGPPPPGLPPPPPLLTPPPVNLRPPVPPPGPLPPSLPPITENEVQVRLRTIREQVTESQMWDQNSLFPVKRRKQVYVNRCFLKKIMEPGKTSDIEKNGMLERCYQLPRTEKLQVNKGTSDSSQLQFNMLNKMQGYQDAFVQPQYSKELDEETGFCKTLIPYMRRVPLDRRLEMHIAVLNCISSFCQSPASSGQNPSVPFTIPSLLPTPLSVNASRSCISDIPPYSQSTQTCGLYPQISHETHRYIQF
The following text describes a protein:
Function:
Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MSEVLPYNEGKMNGYGADSEVSQISFSCRLQDTNSFFGTSQSKRPPKLGQIGRAKHVVIEDDRIDEVLKGMTDKSSPGV
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MEASASTSTARRLRAFRRWMRDHGVVCSNALRLDAAEDGGGGVYVRALAALREGDLVATIPRGACLTPRTSGAAEAIEAAELGGPLALAVAVMYERARGAESPWDAYLRLIPEREPVPLVWPADEAERLLAGTELDKIVKQDRQFICEDWKECIEPLILSGELEVDPDDFSLENYFSAKSLLSSRSFRIDSYHGSGMVPLADLFNHKTGGEHVHFTSVLEASDSDSEDGEDPNNASADEQSTIENSADIPSGDDDEDLEMIVVRDVNEGEEVFNTYGTMGNAALLHRYGFTEMDNSYDIVNIDLALVTKWCSSKYSRRYARARVSLWHNLGYSGCTSQDADYFEISYDGEPQLELLILLYIISLKSDAYDKLASVAHDLIGDDEVDSISSVLKVVRVTSSNQHPDISGLEKLPDVKKLLLNESVCSALVSLVDMRESLYGSNTLEDDRQKLQACSSVNERNLYHSLVLRVSERTILHKLKKHASSWSKTKKRKQL
The following text describes a protein:
Function:
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MNETLCDNNKAPKGGMKTSKKYSLISNQTLNQKENTIWNIVNNGRLPNYGLNEISVMNILYQISSQNLCNSEKNVKIGERENRIYSSIVRSKYIGFGHGIGRSGNLDDVQPKSAGNSILAKLTSSFVKDLIRNFGIKSCEDVYILPYATGMCLSTCLLYLKQIREDSQYVIISRIDHKTCYKCISFCNLKYFVVDMIYKNEELYTDLEGIEKLLEEYKEKICCVMSATSVYAPRNSDDIIKIAHICKKYNTPHIINNAFGLQCTYICKEIQKCFESQGRVDFVVQSCDKNFLVPVNGGIIFSSNREQMKLLKKSYPGRTPVNAYLDLFITLLEMGKDKIMNLRKERVDNFNWLKEKIQLLCLKYNLELIKTSKNFISMAINLNHMYTHCNTDNPKVINMLGSMLFYRNVTGHRVICSPLLNRNYLLKKAREKYMNMLENKKGNDAMMITSNESNEENVKRDLSKKEADIYDNMYSNGFDEIKSVENDMLQNKSNIIKAYEKQIEEEFDKLNEPNTIVIGNHKFKNFGSSYNSYPISYIAFSCVVGIERPELENFVSKLDNAIDYFIKFFKKKKEEELK
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MQDMCKTYNKVTELCFSKCISNMNGFRFTPDETSCVDHCGGKFISSNKVLMATFTEIQFKKQQQMLEEARSQQQAEANKAKMNP
The following text describes a protein:
Function:
Seems to be involved in the anchoring of CDC24 to the membrane of polarized growth sites.
Miscellaneous:
MISCELLANEOUS: Present with 56 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Bud membrane; Single-pass membrane protein.
Sequence:
MFSHYRYKENSCQKREAIPDKSRVSLTFLQKRTDSSNVTVAVAVAVPIGAIIIVLSVVLIVVYRRCKKEPSMQDFDPNFEGDLYYLPKMDSSMNSANSDSNATEKRFIYGGYDDFLQPSIENSQSFKDYVRRINEHAPSAYNIASLASQNNSKLSVPSKHIDLSNKISFESLENSELIVSPQHSNTGQDCDQRCDSTSNPDVNEKSSHNNDNRLKSNYTSRSGLEPQCSREEEENIDRIRSIYNIYFEKSNSTIRSSVTSSIRRDSKLNIATRKSVNMSSQDNPNDTTLIEQSHFGSTTVQEIDSSSSANEEYEDATDYLQVPAPQENKNIASSVYSEVATREKVIPESSLSLTFPPPNGLSTRITSSIYSDTVAKDHIHSAKAPVRALSEGSGQSNLTSAQQYSTYFIDHCNQSNDDNYYYNYPLPLEHPQNYENIGDLPTPTQFIYSTSSHSLTSFKGRPKPPKTLKHVPTARLNGTALNPMDHPEMFYSSPTKIPSTSLTKQFCTPLPYQLRQSVVMTNPSELSMKPRYKPAGSLRNLIKAQYLPGNSSTTTSSSLSQPPSTLSNAINFRVSGLLDDTDILQPPSVGEILPFKASTEDLRKQLGTSHNYEITPYENVHV
The following text describes a protein:
Function:
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins; Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MEGRKEGRKTIKSSQAMVAKQRIRMANKKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSGSSHPVPSCLPPCTHQEKRWEGSAICQLSCMPATEVCASRGMRDYKNTTLKGDIICPEKTFSLPDPVV
The following text describes a protein:
Function:
ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (By similarity). In addition, positively regulates DTXL3 protein levels (By similarity). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (By similarity). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (By similarity). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ) but the complex function is restrained by PARP9 activity (By similarity). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation. Also suppresses PARP14-mediated STAT6 ADP-ribosylation (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Translocates to the nucleus in response to IFNG or IFNB1 stimulation. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner.
Domain:
Macro domains 1 and 2 may be involved in the binding to poly(ADP-ribose). Macro domain 2 is required for recruitment to DNA damage sites. Macro domains 1 and 2 are probably dispensable for the interaction with STAT1 and DTX3L and for STAT1 phosphorylation.
Sequence:
MAYYMDTWAAAPAERPGMIASLSLSFKKAFAELFPQRRRGHSEGDYPPLRGSANNSLEEHYRWQIPIKHNVFEILKSNESQLCEVLQNKFGCISTLSCPTLAGSSSPAQRVFRRTLIPGIELSVWKDDLTRHVVDAVVNAANENLLHGSGLAGSLVKTGGFEIQEESKRIIANVGKISVGGIAITGAGRLPCHLIIHAVGPRWTVTNSQTAIELLKFAIRNILDYVTKYDLRIKTVAIPALSSGIFQFPLDLCTSIILETIRLYFQDKQMFGNLREIHLVSNEDPTVASFKSASESILGRDLSSWGGPETDPASTMTLRIGRGLTLQIVQGCIEMQTTDVIVNSGYMQDFKSGRVAQSILRQAGVEMEKELDKVNLSTDYQEVWVTKGFKLSCQYVFHVAWHSQINKYQILKDAMKSCLEKCLKPDINSISFPALGTGLMDLKKSTAAQIMFEEVFAFAKEHKEKTLTVKIVIFPVDVETYKIFYAEMTKRSNELNLSGNSGALALQWSSGEQRRGGLEAGSPAINLMGVKVGEMCEAQEWIERLLVSLDHHIIENNHILYLGKKEHDVLSELQTSTRVSISETVSPRTATLEIKGPQADLIDAVMRIECMLCDVQEEVAGKREKNLWSLSGQGTNQQEKLDKMEESYTFQRYPASLTQELQDRKKQFEKCGLWVVQVEQIDNKVLLAAFQEKKKMMEERTPKGSGSQRLFQQVPHQFCNTVCRVGFHRMYSTSYNPVYGAGIYFTKSLKNLADKVKKTSSTDKLIYVFEAEVLTGSFCQGNSSNIIPPPLSPGALDVNDSVVDNVSSPETIVVFNGMQAMPLYLWTCTQDRTFSQHPMWSQGYSSGPGMVSSLQSWEWVLNGSSV
The following text describes a protein:
Function:
Branched chain amino acid transport system, which transports leucine, valine and isoleucine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFSRKDIIVLGMMIFALFLGAGNIIFPPMEGFSSGQHWTSASLGFVLTGVLMPFITLVVVAILGRGEELTKDLPKWAGTGFLVILYLTIGSTFAMPRITNVAYEMAWLPLGLTENNANVRFVFSLIFNLIAMGFMISPNTIISSVGKFMTPALLVLLIAVAITVFISPLSEIQAPSNAYENSHSLLIGLTSGYQTMDVLAAIAFGGIVARALSAKNVTKTKDIVKYTISAGFVSVILLAGLYFSLFYLGATSAAVAEGATNGGQIFSRYVNVLFGSAGTWIMAGIIVLASLTTLVGVTSASADYFSKFSVRFSYPFWAALFTAMTITVSQYGLTDLLRITIPALLLIYPVAIVLVLLQFLRKKLPSIKFTYNSTLLVTVCFSLCDSLNNVKMLPESINSLLKHFPLSSEGMAWLVPTLVMLVASIFIGKALHKTHS
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=May be released from membranes by a process known as regulated intramembrane proteolysis (RIP).
Sequence:
MCPSQHSSLKDIHRQLENTAISNPTENADPSSYVDGSNIMDFKHPSIVSSSASSSYPISHVPSVGTRGIPRSYSMASAYPYQVNSNSMDASTAFNLNQDVADKPMLARNSIDSSINTELGPLESNHWFTQAQDHSRQYSSSWDPSIDPFEVKNSLHDSTDLSITHHPHLPINHQGNTWKHANESLQSNQGPVPNTKFVGLETTQTDSYQQSSVNSVVKIEEADATYALREESGQFNTFTGAENPSISPHSLNPNFPQYTEKPALTLLQSPKQNSNYDTSNFQNSVSDSSMQFTNEGMPSPVKGIMSSDDAVAFNFSQYSTVYPQNAPENGNEFETPNKLKRTVSSPCASISSKRSYGDIAQDCSYISSKTNGGGPSDSPSSSSTSVRGSVNDSNSPISSSATFAIQSNGVEPVGLSTQEQNLSPLSKRSAHNMIEKRYRSNLNDKIAELRDAVPTLRSGYNSTTADELKGTYVPLSRKLNKATILSKATEYIKSLQSKNKKLIEENKILQKRLSEYTSVIQASLTAPSQPASLSLLGPPGNTPGHRNVPPILKRSSIGTPSQQAYFPDAPHNCHSVPQNSSYPRPPMQVNRSPIDSMQTIPHANFNEMHNAYSSRYPLKYSKSCNAVSHTSMMHPQEYGGSLPSSTVPSDYNQPQLVSPRAQADQQGLSYKNVGRAVLNGLVGLETVHMLTNPDDAGSSNRFSMSVLPISPSLHSILRFLLLLLAFLCFAMHILLTPEATLRKWASSIYLSFRLECVFISFLIFSVPIYDWGNYLNLRGKLLSELNLESGVAT
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSKRKVRFQEKENGGDAEMQVEDDSKRRFKTKHSLDSDEEEENEEKDDVYNILSTEDIDGQEEATLDHDGEIKITPFNLKEEMEEGHFDNEGNYHLKKEKEIRDDWLDSVDWVKIKEMDKNKDEKMDSGNDDQFEDAVEVDVIGHLKQMQEILKPGETVLKCLRRLGSKPGGVRRPSFKAKRQKTEISDPADVKENKEKLLKLTELADTLLQGGDFGIYQETYEKICFRVKQLGEEKASKDEDDELEAAYKHGGGEGTSTSTSEKSEKPTIDDQVYWEYKWDEASSSEVYGPFSSIDMLHWTNEGHFSDGVFVRKVSDGKAGGQFYNSKRIDFELYT
The following text describes a protein:
Function:
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
Subcellular Localization:
Nucleus.
Sequence:
MSSHQRLNFLLLLYTCAKEHPGLRGTPLAMLAAQCSKLSSKSPPPLADAAVGKGFHPWKKSGGGNNTSASSTTATATSGNNTLATSSASTGGLNNNNNNNNNNGQFNGVSQNGQSGQRQASATTTNTNTSSVTSLGAATATGLGMAGYHQRPGMGATAAGSYGGDLYFSHPHQAPDMYSRTAHHPYEQAWQFQQHVKQEAAAGVNGSSWWDMHQAAAAGGWLDMSGATVNMPSAHHTASAMHAAAAAAAASAAYSASDYSASLAAAGSTAHLLTTGQHLLQDTYKSMQQHHTSVTASPFGVGLGSTGHQPTAASVSSAATSAHQVPSPRSSRRYTGRATCDCPNCQEADRLGPAGAHLRKRNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSAGGGGSGGGGNGSGGSGKGGSSSCGSCSESEEGADDRDCNSQSEPGNPGSVSSPGANSSVNSPTPIQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHLHHAHHLPIVGHHPHHPHHHHHNMMMLQHHTDMHHHHQQVMHSLHHPVHHHMGIGGHHHAGHHHHLGVVDAVGDHIKSGH
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
CVYMQVFKCIVGKCGEMFTDLESFLGHAKSHENNMMYRCPHCPKTLPSLYDLNIHQLTHTLWCFGRIHQCSHCLNRYATPEALAHHQATCSHNYPCPVCQKVFPCERYLRRHLLIHRSSAPHVCSVCHKGFKTDHYLKVHAVVHSKEKPFLCSQCGATFNRQDKLKRHYLVHETVKRYKCPYGSHLGCQKEFSRADKLKAHLLTHSGVRPYECHTCGRSFTQKQRLREHERLHTDVRSFFCSTCQQGFVGRKALEEHACPGRKPKRQSALRSRRRRFNGGRPAILRQQRLARARL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGVKKSPLKRSKTAEFINKHRKLCKNPISSEDNTSQCITRLPVSMYVSLAPLYQQHPLEGIKRQHLNPMVMKYNGDVGGVILGYENVAIMNEGAAKDEELLVKLTPDTPFAFTWCSVDLVVWSPHIGDVLEGWIFIQSASHIGLLIHDAFNASIKKNNIPDDWTFIHNEESTNGSSENDSSTGMRKARSLGHWVDGNGKQLDGKLKFTVKNVYTAGRMVSLEGSLLSEGYHRSQAENLPVVSNTKIIFDDEVSQENKESHKDLELSVLKEDNGDEIMYEKDSSDSNSDSDSD
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MVESSTSELLFISVNHSITLMGKLWLIAMVFLRILILLFAGYPLYQDEQERFVCNTIQPGCANVCYDLFSPVSLFRFWLVQLVALCVPYLVFVIYVVHKVANAISVTASGKAFQLLKTHKAPLKKACVNEAAVLVEQPAWTQSFTGAYILQLLFRTLLEAAFGAAHYYLFGFHVPRRFLCHHAPCTTQVDCYISRPTEKTVMLNFMLGLAALCLLLNFLDFVFAVKRSVKQKSRRKMVLEEIFEEERCFLSAGGADAVLQNPEQQSGEGFKSRRITKDPRGERAVGLGLEPSHRDCCSHPDHEIYSVFQEDVLERNGSEVALCPQEPSGTPRSICVNKRSKLKPPPPPRRDTGACRAPAAPVREASAAVSTRTLTQYRLVDLGSTAELQTDKEGQEKKSEWV
The following text describes a protein:
Function:
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MIRPRSLPLRYPNRSLPLFRFRNHLISRSILTDSSTALPTSSSSAPRSTASFYISNVFPIQLGRLDFRPSIASFLREEALLEHLHAIANDVKVHGFQVENWEVSRKDGGVFLHFSYIAPTEEQTSKEEEKVDEEKAARIGVESTPSSYTQNQPGRLFISPLEESAQKHGGWPSWLGNWWAQKKWHDDRKVPGHTLYSSRAEDGEDAAMDGDEGGLVKGSAGAVKGLQGAAGGGRVWVVKGKQWTEDMNRFPSNRLRVEFDGPDVSQEMLYTLFRPYGRLADIQPPTPVPAGSLRFASVSFSRLSPAAIAINALHGYSTPTNTADFTIRVLSSATDKPIPLSRLRLFYERPLKAHALRDWISSHPRLVLPVVAFLIGTLSYTFFDPIRAFFVRSKLEGVWDINEYSLIKTLRQKFVLPTSFGFLNSSTSETENSEEAIGKNAWADRIEAEKGVEQWLAEYPSTFITITGPPGSGKSSLVTRVLKQQDKPAMVIDCEEIAKAKNDAGLVSALADQTGYYPVFSFMSSLSGLIDLAAVGLIGQKAGFSTPVDQQLRQMLEIVGGALKDVSTHAQKSHQEAFQAQKDQVETDKMRQRKRQMIARGWHDGRLDCVAGNGLSELGVGDEPFEEQDWDSVPLAVPMGGNVAPIQGDTVLTSLTASTDKVESEKLELQTTASTELDVESETIKSLPIVVLKNFAQKTAKGDLWNVLAEWGASLVENKVAHVIVVTEGPTATKALTKALPAKPLNTVGLADADEVNALAYVRDKLRPHTAATTTTTASNSTSTANAGNESQKQGSDPKAYTLSPEDSAQIAKLGGRMVDLENLVYKVRTGSKIKDAVDDIILRNVVELRKAAFGDDSEDAKALQWTRAQAWKVVSELANKGEIPYNKMLQEFPFKGAEQSLKALEEHELVSVSYIDGRASMVKPGKPVFRYVFQALVNDPIFKSSCQIEYNNAIIAKSESDIKAYEQELMNLKNITTEGGSNAIGVSGGWLGLGGNSAIRDRGKWLLDKMGGLVDKVGKLEKENAEMVKVLSSGR
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MSLIKYAKTYIANQAKYAHLNAFVSRVEPSALLNVPPNPPLATDGEGNADWHNLRGMPVAVKDNICTKDLKTTAASGILKDFTSPYDATVVKLLREEDVVVVGKTNMDEFGMGSHSINSHTGPVKMQRYDGEEASAGGSSGGSALAVASSQCWAALGTDTGGSVRLPAAYTGVVGFKPSYGLLSRWGVIAYANSLDTVGILAKSPRNAERVFEKLNHALSAYYVLAPAEASSNLAKYDGVRFGSRADGIDGTPESVLFAKTRGQGFGAEVQRRILLGAFSLSAQAIDNYFIQAQKVRRLVQQDFNNVFAKANPLGNEGTTSGGADEKVDVLLCPTAPTLAPALSDVKQQDPLKAYMNDVFTVPASLAGLPAISLPVHITKEEELVLHGDQDIRESAGMQIIGQYGDDKLVLNAAQSLQLALKAIQVTAKPDMTAWGHSSLGKTSARERKKYEENANELGLSMAEAIPIIEARKLQAAKQLTATFYEALGSARLNEAGSFHRQSRQEYIARFIDEEDPLLAEKLLYAKQIEYLKRMEDRREGQERLARRYQREADMFNASEAIKAEDAEPPKANDTGRPANQQHESKPLHPLGSSFYRNGVAIKNWRRATFKGADIDLKRDAGKLYTNSPPPPGLEVKKDVNFWLLKPKEPPPNLPPPPELEVKKDIYVWRLQPKESPSGRRRTKAKKQAGPSIEELQ
The following text describes a protein:
Function:
Probably functions as a sodium/glutamine symporter for glutamine uptake.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRMLKEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWIIAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGIVFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVLYIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMGSAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAMIVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFYKDVLKNHNGIECWPVSDTKTDTHNKQIS