lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPGCRISACGPGAQEGTAEQRSPPPPWDPMPSSQPPPPTPTLTPTPTPGQSPPLPDAAGASAGAAEDQELQRWRQGASGIAGLAGPGGGSGAAAGAGGRALELAEARRRLLEVEGRRRLVSELESRVLQLHRVFLAAELRLAHRAESLSRLSGGVAQAELYLAAHGSRLKKGPRRGRRGRPPALLASALGLGGCVPWGAGRLRRGHGPEPDSPFRRSPPRGPASPQR
The following text describes a protein:
Function:
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates sporozoite proteins CSP and TRAP. O-fucosylation regulates stability and intracellular trafficking of TRAP but not of CSP (By similarity). Probably by regulating protein O-fucosylation, may play a role in parasite transmission to the mosquito vector and/or infection of the vertebrate host hepatocytes; however, POFUT2 involvement in transmission/infection is controversial (By similarity).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MKGRAHIWVALLLACLPPRFRNLDKDVSSPVCRTDDVYTGDAFYPFKKKKYVLYDVHIGEGFNLQKEVLYRVALAVYYLNQEERTHVHYLVLPPWCYVTHWGRERTNARIKWSIFFNLKALQNVIPVMEYAEYEGQFGPHTDYILSYRHIIGEWPKRGDKKSFQVLKLDKCQVKGYKLKKNLRKNCDHKYSVEYSGKCTNVKGKKMECLEFFFITSHFVSSTLLDIFQYDADSVLIKHGSNILVAFMNELVDANLEDVLPYSEDLINEGDQFVEKNFKSSKNYISCHLRYTDFRKISTYDVSPVGISLLKLLYIMFLRKSTLIFVSTDEKKEVKKVIDSQFPQFKHFFFFYENEKLHTGQVAIVDQWICARSGTFVGNIFSRFSMHIKWERSLIGKGGPDHNLDLCGYSISTNHELRKKYSDVQDAHLDEEALQKLRPLYMRLSQKDRDFLRTICYDFAHYYPQNVSIYRRGERREEGRLM
The following text describes a protein:
Function:
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNSPISLDMGAITYNMDDLYKELAIYSNSTEIPLQDSIFCSTEEGPLLTSFKTIFMPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKINFYCSSLLLACIAVDRYLAIVHAVHAYRRRRLLSIHITCSTIWLAGFLFALPELLFAKVVQPHNNESLPQCIFSQENEAETRAWFASRFLYHTGGFLLPMLVMAWCYVGVVHRLLQAQRRPQRQKAVRVAILVTSIFLLCWSPYHIVIFLDTLERLKAVNSSCELSGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCAGPASLCQLFPGWRKSSLSESENATSLTTF
The following text describes a protein:
Function:
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
Sequence:
MKWLGESKNMVVNGRRHGGKLSNDHQQNQSKLQHSGKDNVKAGRNAGERRSSRCNGNSGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPPRSSRHFSKSDSFSHNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQGRNDASK
The following text describes a protein:
Function:
The small GTPases Rab are key regulators in vesicle trafficking.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MEESKEALQLKIIVIGEPSVGKTSTIRKYCHGVFDQLYRATIGVDFAVKFTTVDERDVELRLWDIAGQEKYIAMTRVYYNGAHGAIIMYDLTNPDTFAATDRWKEDLENKVKFNEQSIPALLVGNKADCLSEEELKKAQEDLMAKVAEQKYSDGILTSAKSGLAVEEAMAKITRLIFKQFSDLVNPKPDANNVDISKQGQQTQKEGGCC
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways and could also regulate other AtERFs.
Subcellular Localization:
Nucleus.
Domain:
Contains a slightly degenerated ERF-associated amphiphilic repression (EAR) motif, which may be involved in the activity of transcriptional repression.
Sequence:
MRRGRGSSAVAGPTVVAAINGSVKEIRFRGVRKRPWGRFAAEIRDPWKKARVWLGTFDSAEEAARAYDSAARNLRGPKAKTNFPIDSSSPPPPNLRFNQIRNQNQNQVDPFMDHRLFTDHQQQFPIVNRPTSSSMSSTVESFSGPRPTTMKPATTKRYPRTPPVVPEDCHSDCDSSSSVIDDDDDIASSSRRRNPPFQFDLNFPPLDCVDLFNGADDLHCTDLRL
The following text describes a protein:
Function:
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
Sequence:
MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRRQQHLRSALETFLRQRDLEAAYRALTLGGWTARYFQSRGPRQEAALKTHVYRYLRAFLPESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREADEGLLRAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEGAFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSGSRQGLLGPRACVHPSPLRRDPFCAACQPLRLPACSARPDTSPLWLQWLPQPQPRVRPRKRRRPRPRRAPVLSTHHAARVSLHRWGGCGPHCRLRGEALVALGQPPHARWAPQQDWHWARRYGLPYVVRVDLRRLAPAPPATPAPAGTPGPILIPKQALAFAPFSPPKRLRLVVSHGSIDLDVGGEEL
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MAKQNNKRQFLVPEYASELSSLSEFLAEFRDNSIVEIDNTYGQRKYMVELQKIANRQTNRIDIYVEDLEYFFNDRIDFVNKIKTNTLSYQRLLYDACDTLMPQQSRDFDQNFDLFDEEINVQRQQNMDQDGTNNQQKRLPPELIRRYQLFIIRGPQTKQQDLQLQQKLWQVRTSEVRPQIIVACFSCDACGYENYQTVHGKTFTPMLDCASDKCRDNKVRGRLIFNHGSSKFISNQEIKIQELKEQLPKGSIPRAFTVMARGDSNIRICSPGDMVTIQGVFLPVEKEGFFANKASFYSTYIEAFHIKRDKKKFKEIDIESVSGHKIFEDIKKYPFSDLYMKLAKSIAPEIFGMEDVKKALLLMIVGGVSKEMHDGLKIRGDINVALIGDPGVAKSQLLRYISQVSPRGVYTTGKGSSSVGLTAAVIRDPITGEMALEGGALVMADRGVCCIDEFDKMNESDRTAIHEVMEQQTVSIAKAAAANPLYGRYNKKQTPHQNINLPAALLSRFDLIFILLDEINHEADTKLASHIGRVHQNKYKENETQDLYSVEEITTFVALSKQYEPILTADIHQYIADQYVERRKQTFDKTLDGYSYTTPRTLLAIIRLSQSIAKLQLADRVTQRDVEEAIRLMDISQESVRRAQQIDDTVQRKDKTAKLYELLSSLCNKNKGTITKDSFVRQAISKGSQMQEIEEFLNTYSSLNQIQIHGDQNDRITLVS
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.
Miscellaneous:
MISCELLANEOUS: Present with 1160 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MQSSTSTDQHVLHHMDPHRFTSQIPTATSSQLRRRNSTNQGLTDMINKSIARNTISGTGIPTGGINKNKRTRSTVAGGTNGTALALNDKSNSRNSVSRLSINQLGSLQQHLSNRDPRPLRDKNFQSAIQEEIYDYLKKNKFDIETNHPISIKFLKQPTQKGFIIIFKWLYLRLDPGYGFTKSIENEIYQILKNLRYPFLESINKSQISAVGGSNWHKFLGMLHWMVRTNIKLDMCLNKVDRSLINQNTQEITILSQPLKTLDEQDQRQERYELMVEKLLIDYFTESYKSFLKLEDNYEPSMQELKLGFEKFVHIINTDIANLQTQNDNLYEKYQEVMKISQKIKTTREKWKALKSDSNKYENYVNAMKQKSQEWPGKLEKMKSECELKEEEIKALQSNISELHKILRKKGISTEQFELQNQEREKLTRELDKINIQSDKLTSSIKSRKLEAEGIFKSLLDTLRQYDSSIQNLTRSRSQLGHNVNDSSLKINISENLLDRDFHEGISYEQLFPKGSGINESIKKSILKLNDEIQERIKTIEKDNITLEKDIKNLKHDINEKTQINEKLELELSEANSKFELSKQENERLLVAQRIEIEKMEKKINDSNLLMKTKISDAEELVTSTELKLEELKVDLNRKRYKLHQQVIHVIDITSKFKINIQSSLENSENELGNVIEELRNLEFETEHNVTN
The following text describes a protein:
Function:
Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate signaling system BtsS/BtsR and their respective target proteins, YhjX and BtsT. YpdA activates YpdB by phosphorylation in response to high concentrations of extracellular pyruvate. Activation of the YpdA/YpdB signaling cascade also promotes BtsS/BtsR-mediated btsT expression.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MHEIFNMLLAVFDRAALMLICLFFLIRIRLFRELLHKSAHSPKELLAVTAIFSLFALFSTWSGVPVEGSLVNVRIIAVMSGGILFGPWVGIITGVIAGIHRYLIDIGGVTAIPCFITSILAGCISGWINLKIPKAQRWRVGILGGMLCETLTMILVIVWAPTTALGIDIVSKIGIPMILGSVCIGFIVLLVQSVEGEKEASAARQAKLALDIANKTLPLFRHVNSESLRKVCEIIRDDIHADAVAITNTDHVLAYVGVGEHNYQNGDDFISPTTRQAMNYGKIIIKNNDEAHRTPEIHSMLVIPLWEKGVVTGTLKIYYCHAHQITSSLQEMAVGLSQIISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNALNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKKELYQIKDYIAIEQARFGDKLTVIYDIDEEVNCCIPSLLIQPLVENAIVHGIQPCKGKGVVTISVAECGNRVRIAVRDTGHGIDPKVIERVEANEMPGNKIGLLNVHHRVKLLYGEGLHIRRLEPGTEIAFYIPNQRTPVASQATLLL
The following text describes a protein:
Function:
Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAEASPETGRFRTKSSPELFFPATDSEGEEQNDVPLTIVHPTQSTSSKFSINIASSSRPQHGITTGDFEATSQTSAHDNVDDDFSIVGHNPASSHPQGTIVAPRRKRSLQQAHSHHSSSSSSPVPSAPVIRADFRKGFLGEFVCEGWSLSKGRGYCSPGTKIVIERPKSKSTDVGAPKPGRKDSGPVRLVNGKVVGGVKSKQMTLGSMMAKKVEPAKKVKATTDQIIRFRNERGFEIGRLSIHEAGFLAHLLDTGVIQLSGNVIDCPQNLTTGCTILLNIKVYLARKAFENFGKHKREEHFSFWKDQRETAMEEAMRLRKDSLRSLFERIGVKPIQSSALSKVTPIQGVLNRQKGPDLEGSRLRSSPSTSTAEEKGKGRAAMPAVDDDGEDSGDEAEKLDEKQMNEIDSIYRKAQQGDTRLDEMDPPSTFLYTLRPYQKQALTWMNAREKGDSSVRNESLHPLWEEYLFKKDQLPGEPIEISDDDEQPDSTRKFYWNPYSGELSLKFPTSQNLSRGGILADAMGMGKTCMMASLIHTNREEKPAGNLESQTRDGVEGEIDEEPASKRIKFKQVTLSNQWRAVPTAPKVESFPRATLVVCPVSLAAQWHDELRKMSQQGSINSYVWYGGDRVDIEALLAGDGKERVDVIVTSYGTLTSEYQKWLRTKDRPNYEGGSLYDHEFLRIVLDEAHNIRNRLAMVSKACYELKGQRRWALTGTPIVNRLEDLYSLLHFLRITPWGNYSFFRSFVTVPFLNQDHKALNVVQYILESCLLRREKTMRDKDGRLIVDLPPKTVEIKVLQFSRAERQIYKFLEERAKKRFIDLDADGRAMSNYTSILAMLMKLRQCVDHPLLVLGKSGEDGELGEKILESGAGNGEGNLRDMIAMYAGGIRAETPEDVDKAYAAKVLKELGEQEDTPICELCSNEMFDEVLLPCYHRSCQDCIVEWIGTCEDQNKIASCPSCGKGPIKLADLRSVQRRHKRVNPITDAYPGGRDPNLKSSNDTTVTLGKVDLVTSTKLRALLRQLEEIRQEDPKAKALVFSQFTSFLDLIEATLTKQGIRWLRFDGTMSQAQRANTIEEFGRKTNEPLILLISLKAGGVGLNLTMANYVFLMDTWWNEAIEQQAIDRVHRLGQNKPVYVTRYIIKGTVEKRIMKIQRSKTALVNASLSNGAKTKETTLADIKKIFGMDEEDSEGEVY
The following text describes a protein:
Function:
Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.
Sequence:
MSGWDDQVVIGRKTTGPRVARDQATVNAARRAGEAIDASKKSVINASHVGPDHQRIAKLDRENDVAPPAKIKPSVAQAMKDARIALSMTQKDLAAKTNEKPTVIGDYEAARAVPSPQILAKFERILQVKLRGKDIGAPLAPKPKKT
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTQTSKRRPVLYQMLLAILSLISTSAPTMGTQEALKAKGFDDSCKIANELMKYGSYAETITKTLTSHLFEVETILHDIKKLMKSGTLARNDDNINLLMHTRTTVDEAKAAVRTHLAAAIDAGNEGAFVAGAILETTHLFFAANNGGSNYCMSNDGAGGRAAINDIPDCKDRDAVRRTFKKEAVATLTGAQHALTNFGTGGDGSKGVDATKSCRLSATDGTNGVMGAGGGTAPTIYLMAGLLKLTGSVPAATSWSTGHPLETNNPITKVKALKPTCTASLDAATAALGQLTTLGSADPNPTFKAITTTEAKLGLGDTEQTVEISVPTLKAAHKAIKKLRGDAVTASGKSTETTKRAQLTQEITPPPPPTECNPITTEGGCNEIKIEADCNATAACSFNKTETDENKKCKLDTEKAKKKSVSVTQAQTGGPETTTEKCKDNKSEAVCKDGCKWEGTECKDSSILVNKKIALIVSSFVGFVEF
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MSPSRIFFLFCFFFRTSSSDILDTITQKGKFPSWVKPGDRKLLQASAVPADAVVASDGSGNYMKIMDAVMAAPNGSKKRYVIHIKKGVYNEHVMINNSKSNLMMIGDGMGATVITGDLSWGRDKLDTSYTYTFGVEGLGFSAQDISFRNTAWPENHQAVALLSDSDTSVFYRCEISGFQDSLCANIKHHSIRIAKSEARLTSYLVRQLSSFKTDILVRKGPTGQQNTITAQGGPEKPNLPFGFAFQFCNVCADPEFLPFVNLPKHSSEDRRRLEALLTSSWLEWNNTAVYLDTLYYAEYNNHGSRAAVQNRVKWPGYHAGPAYCILRPKAKFRQSLLYAFR
The following text describes a protein:
Function:
May be a regulator of keratinocyte proliferation or differentiation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEKKSDQPSQCSAVKQPGLSGLIPPSHFETRHHVSVPPPSASVPSRSPICEPWADLARELVQLRQANEELKKRQEWEREVMQSRPLHCQPLEGPPTESRALEIIAHQIQEIRRLEIALADAHDKDEKLQKMQQEVKEMNKRQKENAQTEQRRNAAEEVAARQREAELVTALQHHKREAEKLRSRVQELEVEFNEDQEQKAQELIHLKNDLQTVTKEREMLAGQLSQSQKALDAQNSLVQQLKTYIGELVPDNKMLEEKNREKMELLNTLQALEKERDALQTTLSLLQTRLSSLTNILSLQENEICKKGIPKDYEKFQQLLSRWREKVFCLMVQLKSEEIHKEDDHRKSREKISSLEKALQEKDQQQILLSHTLQDRTAELEMERVHSKCLQNELSTAKAKSDHLASKVEMTDKAVLNLNQLVDNFAQALSTQEISLKGALSRLVTLGQRVSFASKRVDTTQGLVAQRLALLRLTKDERTKPSSTHGEICQPSYEDLEAEVKLLNEERDRLSAELKRSAHLIESQVAETRETLEAEIAEYQRTISFLRHSIHENEKTTRALGEQLGVAEKKLQEACENTEQLREQLLEQKAEYETELQRRVNELEDHHIQQLAQMEKHLNEARREHTKAVVALRQSERQMQREKTRNQETLRTFEDAAQTLQEQLSQQLRQAERDKNLMIATLKQEGLLNAYRKNRTGAAQTLQTEVEQANKQNVKHSSLPCTTESLSSMVANLQSLGTTLLDDEDDQEEED
The following text describes a protein:
Function:
Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity.
Subcellular Localization:
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome.
Sequence:
RLAPEYEAAATRYGVSGYPTLKDGEEAGAYDGPRTADGIVSHLKFISDKDASVVGFFRDLFSDGHSEFLKFAHTNVESLVKEYDDNGEGITLFRPSHLANKFEDKDLLTAYYDVDYEKKTFSHELSDFGLESTTGEVPVVAIRFVMQEEFSRFLQDYFDGNLKRYLKSEPIPETNDGPVKMDATANDVPSPYEVKGFPTIYFSPANKK
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MDGETRSQRSQRSIRSQGEYPADGPRYIQTLTDTETVYESPIDINISKTKEIQVPPLTWHHLDLPPKKMKVTNSGYTLILSAKWHQERPYISGGPLLGNYVFSQLHFHWGKNDGEGSEHTIDGVRYPIEMHVVFFKANYLTQESALKEKDGIVVLVYMFKGGKNEAFQVLIDHVMEVQKPHTSRKLNPLPLSYFVKKFEQDYLLYWGSVTTTVCLHYILWLISREPMGVAAEQVDELRSMLDANEELLQGNFREVQSGRTQVFHANPSGSKYATLLALP
The following text describes a protein:
Function:
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MASLKRKRHRGGTDSGTSSSEAAAAAGGVGAATAAAPLASGSPVTRARRATRQTSTAPLPVLPDPEPPRRRRRRDSTGTGTGTGTGLATDRQSPTSPPLLPPPGPPPPPPPPAHRDKENIPMQSNSHHGHAPIIKTRLTRHTGFDFDPPSSVPTPPSSSSNSNSNSNSSSHPPRPHAASSHSSSNSSHSGPRAITPARSITIKTSTSTAHQSPLAHPHQAPTASPLRAPAPNPTTKILPGPLAGGQARHDSTTAHGHGRSATGPVVLPHHSIVGQNKTISMAPSVPPPTQHQQQQQQQQQQHTHRSPIARPGPSGGKSDRPERAPGERPDRNIDKVVLGDICFRAWYPSYYGKEVLGEGPPSVGTTIANGTNPSNQAAHGHQPHHQPPMLDRLYVCPCCFKYSKELVAWRRHVCLCEARGHIPGTKVYVHPKGRRTVLVPTGPAPKPGRGKRGSIGQKMVEEVIQDEGEWTIWKVDGAEDMLFCQNLSLFAKLFLDNKSVFFDVSGFHYFLLVFTPPDPPTDPDSDVTEVVKPRGQVVGFFSKEKMSWDNNNLACILIFPPWQRKGLGALLMGVSYEISRREGIIGGPEKPISELGKKGYKRFWAGEIARWLLSLEPTGTTPGEETVVDIEDCSKATWIAPDDCLAVLREMDVAEDAGKGPPKPKIHEPSEEEVGTTPSEAPAPAPAAAAAVVVEDVPRVRITLEAVHNWVTRNRISLERTCDPAGFIDDFVMEEPSSEEEG
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product. The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD. 4-hydroxy-L-tryptophan is accepted as substrate by psiD as well. The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine. The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin. The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin.
Sequence:
MIAVLFSFVIAGCIYYIVSRRVRRSRLPPGPPGIPIPFIGNMFDMPEESPWLTFLQWGRDYNTDILYVDAGGTEMVILNTLETITDLLEKRGSIYSGRLESTMVNELMGWEFDLGFITYGDRWREERRMFAKEFSEKGIKQFRHAQVKAAHQLVQQLTKTPDRWAQHIRHQIAAMSLDIGYGIDLAEDDPWLEATHLANEGLAIASVPGKFWVDSFPSLKYLPAWFPGAVFKRKAKVWREAADHMVDMPYETMRKLAPQGLTRPSYASARLQAMDLNGDLEHQEHVIKNTAAEVNVGGGDTTVSAMSAFILAMVKYPEVQRKVQAELDALTNNGQIPDYDEEDDSLPYLTACIKELFRWNQIAPLAIPHKLMKDDVYRGYLIPKNTLVFANTWAVLNDPEVYPDPSVFRPERYLGPDGKPDNTVRDPRKAAFGYGRRNCPGIHLAQSTVWIAGATLLSAFNIERPVDQNGKPIDIPADFTTGFFRHPVPFQCRFVPRTEQVSQSVSGP
The following text describes a protein:
Function:
Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket.
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus envelope. Note=Localizes to the nuclear pores.
Sequence:
MNTSFGSVVPSTNFNFFKGHGNNDNTSANSTVNNSNFFLNSNETKPSKNVFMVHSTSQKKSQQPLQNLSHSPSYTENKPDKKKKYMINDAKTIQLVGPLISSPDNLGFQKRSHKARELPRFLINQEPQLEKRAFVQDPWDKANQEKMISLEESIDDLNELYETLKKMRNTERSIMEEKGLVDKADSAKDLYDAIVFQGTCLDMCPTFERSRRNVEYTVYSYEKNQPNDKKASRTKALKVFARPAAAAAPPLPSDVRPPHILVKTLDYIVDNLLTTLPESEGFLWDRMRSIRQDFTYQNYSGPEAVDCNERIVRIHLLILHIMVKSNVEFSLQQELEQLHKSLITLSEIYDDVRSSGGTCPNEAEFRAYALLSKIRDPQYDENIQRLPKHIFQDKLVQMALCFRRVISNSAYTERGFVKTENCLNFYARFFQLMQSPSLPLLMGFFLQMHLTDIRFYALRALSHTLNKKHKPIPFIYLENMLLFNNRQEIIEFCNYYSIEIINGDAADLKTLQHYSHKLSETQPLKKTYLTCLERRLQKTTYKGLINGGEDNLASSVYVKDPKKDRIPSIADQSFLMENFQNNYNEKLNQNSSVKPQINTSPKRVATRPNHFPFSQESKQLPQISQSHTLSTNPLLTPQVHGDLSEQKQQQIKTVTDGGSPFVFDQSAQNSTVEASKAHMISTTSNGAYDEKLSSEQEEMRKKEEQRIEEEKTQLKKKQENADKQVITEQIANDLVKEVVNSSVISIVKREFSEANYRKDFIDTMTRELYDAFLHERLYLIYMDSRAELKRNSTLKKKFFEKWQASYSQAKKNRILEEKKREEIKLVSHQLGVPGFKKSTCLFRTPYKGNVNSSFMLSSSDKNLIFSPVNDEFNKFATHLTKISKLWRPLEMQSIYYDNLTKKFPSNSLTPANLFIYAKDWTSLSNRWILSKFNLQTAQDSKKFSNNIISSRIICIDDEYEPSDFSDLQLLIFNTGVTNPDIFDLEMKLKDDGEELIKLITGISLNTNICFSLLIIYWESAENTLSESTIKHLLKLNRISKNYSSVIERIDLMNLTEESPHKCLEDKLSEISHSYVYKLTERGKYDKTLRQKRSLAGIHSRSTQLQTTKDIDQKMKKMLEKEKNKYQQQIGERNTYAHLESHIDASPRSKKRKLPILLSTSHSSQFKTPLASRLNTSGSSTSPPLPSHLAMKFRKNSRVTSLHTVLPVSTPSHSNNIPAASFSGNNTTDIQSQQLIENQKSTSVYLNNVSERILGNQEICQTPINPVTPVLDGADQGKEDIPDSILELKILIDSVKKKVNND
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MSEERTERPERTERPERPQQRGSGPRKRRPFQRRKVCRFCADKTLVIDYKDPRVLRSFITERGKIVPRRISGNCSAHQREITEAIKRARNIALIPIASTHVIA
The following text describes a protein:
Function:
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Sequence:
MSNSFRDQEQGLQAVFRAARVISHMFSQTIGPYGFSTIVHNVQDTRTTQDSQSMLKDILFPDVFENIGMKLIRDTALRTRMRFGDGAKTTALLIEALLAEGMTGIQKGLDPHEIHRGMLLAEKKIQEVFYRETFPLSDLEHTVYVSSIARRCNSEIASVLSSAVGYGGKNGYYIVEEHEEHETYWHAEEHAVWDFGYASPYFITHAETGTVEYSQVYILVSEQPLHYSNPSFLTFLQSVVQAGKTPLVILAEAFDKELLAMLEMNQIERVFPVCAVKVSGKHARESLEDIAVLTGATLLSEMDFEDSEEERITNRLGFVAGICVSSTSLCVPRETDNKQRMAEHCAFLQDKLSFSQEEEASARLRRRLARLSSGEVCIHIAADCIPQEEIGYITSSIRAMTESLRSGCLPGGGCAFIRAAREISVPLALSPSERFGFLAVLSAAEKPFRAIVTRSRRVEEEVFSEVFSQADWRVGFNGVSGFVEDIVSQGICDGASCIQYALSHAVGTTGLLLTSALFIASQEPMLREENSEE