lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MSTTTNDDSSSELPSSADFLIDALPGQPKSTTQSIIQYAGHLPSHPPSTLSPPPDSHLWFWLIRSKHIADREKFVIWFNGGPGCSSAEGALMEIGPLTPSLKNEPGKPIELVESTIGWSEYANLLFIDQPAGTGYSYVNVGDDVRELAGASEQVVVFLKNFYKVFPEFSKIDTYLAGESFAGQYIPYFAQAILDTAALSTPLLGLMMGNPWINPKVQYLSYLDFAYERGMIVKGTSSAVEAEKSFQKCIKALKGKTESQRILVDSCEEGLQSILDAGAQVVNGTKMTPVPYNITEMSAEESVEWPKKNKNLKAYLVQNSTVSALHATAKTGKWTLCNDTIGKEMWVPRSAPSSTLLPALVKKLKVIVYVGDQDYMCNSLGLNRSISEMEWNGQKGWGVDDKGQQIVPQDYYVNGTKQGTWTEARGLTFVKYDRASHLVPSDAPHAAHDMLLRFMGVDALLAAGPGGSLSSQVGTDDHKGIIVKTHPNGTLVDQDNLITDLDKKPSIGAAPILETIEERQAYYGPRQTIALIVLLTGLSLGLVMLFKWRRRRRRARHGSKNKGRAISMQSRSPEAYGHRNTLLRRSPSPTQRKQSRHPTRKLNGNHLTLDEEAQALVHAEETSNLEPTTLSRRTSLFSSDVPSHSRHESQIFSLEDEEEEDDDHHHQNV
The following text describes a protein:
Function:
Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPAVTREEGPRLGVSVWEQETRSMTESGKMLQGGGGDGEKNRCQDTLWVETVLPLQMLLLPPRPPHPRSSSPEVMDPPPPKTPPFPKAEGPSSTSSSVAGPRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREATPGEPGPRKGYSCPECARVFASPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQDAAELAQHVRLH
The following text describes a protein:
Function:
APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MVMLLLLLSALAGLFGAAEGQEFRLGKCTSPPVQENFDPNKYFGRWYEIEKIPTTFEKGRCIQANYSLKENGKIKVLNQELRADGTVNQIEGEASPVNITEPAKLEVKFFWFMPSAPYWVLATDYENYALVYSCVSIINLFRVDYAWILARNRHLPSETVDFLKNILTSNNIDVKKMTVTDQENCPEFS
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E2 enzyme UBC8 in vitro. Plays combinatory roles with AIRP1 in the positive regulation of the abscisic acid-mediated drought stress response. Plays a positive role in abscisic acid- and high salinity-regulated seed germination through the ubiquitin-proteasome-dependent down-regulation of ATP1/SDIRIP1.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing AIRP2 exhibit tolerance to severe drought stress.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The RING-type zinc finger domain is required for E3 ligase activity.
Sequence:
MRKSFKDSLKALEADIQFANTLASEYPEEYDGGYVQMRLSYSPAAHLFLFLLQWTDCHFAGALGLLRILIYKAYVDGKTTMSLHERKTSIREFYDVLFPSLLQLHGGITDVEERKQKEICDKRYRKKDRTDKGKMSEIDLEREEECGICLEIRNKVVLPTCNHSMCINCYRNWRARSQSCPFCRGSLKRVNSGDLWIYTCSAEIADLPAIYKENLKRLLIYIDKLPLVTSDPNLVPYAPLPR
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MSTTTSNDDSTANAGTPSTHEIPATTPSLPSVSREDLIASAVKFLRDPKVQSAPLAKRIAFLETKGLTSGEIETALFRATSTTAGANGPSLPPKDLAVQSADGHSSNNDYYAQVVQQQQMMLLQQQHQMGLQRLQQQWTWKDYALGGIGVAGLVYGVFLLSEKYIKPLINFPTASSIKTDTDKIEAQLETTSKSVDLVRVQTLDVIKAIESNADDLQKSLVGMAEVIKGLEEADEKRGSQIEQIDQEIGTLKAMIFKMTERTKDQQDEMLTDLQNELKSLKSLLLNRRIASNSGGSTQINGSGVELAGTGSGGLVGQVTAQCIQEGSMAAIETIPDVTNESGFVKNLLSSNTKPAIPAWQIEAARAAKEKRSVASNSLGNSGSSASVDA
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MKSIFLSLSLLASATVGVLAAEELGIDVTVPVECDRKTRKGDKINVHYRGTLQSNGQQFDASYDRGTPFSFKLGGGQVIKGWDEGLVDMCIGEKRTLTVPPSYGYGQRSIGPIPAGSTLIFETELIGIDGVPKPESIVYKQAAEKAEEAASAVEEKVAEATDKAGGKIADATKKVEEKAEEASANVVEKVASVVSGAAEAVKTVVADTDDVQEHNEL
The following text describes a protein:
Function:
Acts with RNA polymerase to initiate transcription from late gene promoters.
Sequence:
MAKRVSLPDVVISAPKAVFKPAKEEALACILPKYYKSMADVSIKTNSVIDKCWFCNQDLVFKPISIETFKGGEVGYFCSKICRDSLASMVKSHVALREEPKISLLPLVFYEDKEKVINTINLLRDKDGVYGSCYFKENSQIIDISLRSLL
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MLNLFRNRKRNGAGPTIKKAQKMPELDDFLSNQDYEGAISLLNHKLKAGNLDREEEDSLQLWLAHCYYRLRNYEEAANVYTFLMNKDDAPAELGVYLACCKFYLKQYIEAKSIAEKCPKTPLCIRLMMNVSLRLNDEKRILTFHSSLGDTLEDRLSLAGVNYSRMHYQDAIEVYTSVLQTSPNLIGLNVNMALCYAKMDYPHVAYNLIKNYLRNFPNSPFAKNLLLSVLYRTITSKTTVDEKSELARNIDQEGLTMVSDMEALLKQKLYPEIEYICKHNLVLFKNCETALQVLPSLMKHIPEARVNLILYHLNKNNVKDAISLCKDFDPVTPYEFLVKALTFLRHGQETNSREHLKIAENFFQMVGESGLVQDTIAGRQSSAAYLFLSFKFDDVITYLKSIEAYFTNNDDFLLNLAQAYLMYKNYVAAEKLFIRVSGPERDKILYKSMLARCYVRNKKPQSAWDMMLKTNNPSDRMSLLKVIAQDCYIANEFYYASKAFHEIEISDPTTENWSGKRGACAGLFRQLANHKTDPILISQMREVVHLVAMKPHSNCEFLLKVVRNWAETHNVNIIN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAYRGRGRGGFGGGGGFGYATQVPFELFPDVDLPNVKGILDPDKKINQGKSEEENLVNQSRKFQKIWKGSPFYLEQTTSKERQNTEVERYSDRLKPKTTIRRGALFDILELKGFPQELTGGSRAQEPGRKRVRWNPDSELQKLDLFEKLEQRQGNNDGKEKKEGEGEDEDEEEEEEEPEEDFSDDDYQKNQDFDDDDDDFNMEDDGDDEPLL
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular Localization:
Nucleus.
Sequence:
MSSESRENEVKAETKDEIANDGSPQLNGDNNIQSSDGHNDENEESLSRKRDSSGATVGDLKQEEKESMPKKEPEPTVKKIRGSGMPPPQQKYCLAIVRQLKRTKNSAPFKVPVDPIKQNIPDYPTIVKNPMDLGTIEKKLTSYEYSVPQEFIDDMNLMFSNCFLYNGTESPVGSMGKALQEVFERQLKQLPDAEQPAAAPVKKSKQKSASTAPPRTRRNSSVSSTSASVAASTAPKAASPAVLPEGKPRRRKNNSQMRFCSTVLKELYKRQYESFAFPFYQPVDPVACDCPDYFDVIKEPMDLSTIQSKLNKNEYSTLEEFESDILLMFNNCFTYNPPGTPVHVMGRQLENVFKEKWEARPKFDDATLVKQQEAETDALFDNGEEEEALMSEEEINGAKFAAVDKQISMLQDTLEAMKAKKMNRMRKPRRRDLTKEYGPITYAMQNELAERCNYLSAEQLSNVAEILREEMPWLRDTDEIEIDVGNMKPEVFHRIYRYVCKPDADSSEPASPVLMPTKPEKKKGRVLSETEQAEKIRRLQQQLDRFAGKTSPTSPESNNAANVSDSESDNESESSESA
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA processing and stability. Together with Fmr1, regulates axonal growth in the mushroom bodies and neuromuscular junctions by repressing the translation of several mRNAs, such as those of chic and futsch.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGVDQMKIPGNTAKSVEERNIPWSQQVDEASYENLSSPTHDEVSGNDNSMQFQYPPFNFKENCNTPWNNMNKGRKANANHDSYRRHGHSIPNNTRRDEHQVNPWNSRKPAAQSFRNENDQPSTKLDNRTSDEAQNQEVVAAPKKTTWASIASQPAKLTSRAASTTSNSKKKGPGMPPPPMVPGKHNLDVNVWDLPNNKPPPVPSPPSPIDLGYSDLSSDFSISSNTAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVSPTGPVRRNLGPQQPVHHAAPRPATNAGPFGPPNARRHDGGPHPSRNSERSGNYSSFRGSEFESASKFEYRDENQSRPVEATSATEELPVDSQLVLDELKDKNNYNPKVLDLKKAGSARFFVIKSYSEDDIHRSIKYEIWCSTDHGNKRLDDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVKWIYVKDVPNGTLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKKQEEEVSSKRPPMHGPDGNNHAPAPLARSFNRQADDKDRDRDGRGGMSQKHFNSGGGAGFRNPGHRGGAGSGGSHNNYSEYRRGFDIHKSSSDYQFKDRDGPDFDRENDFGSHYGSNNRKNEYKHNNTNKARLKTRDRDFSTEQIKIGVRFKDTDKDKMRSNEYS
The following text describes a protein:
Function:
Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. With tpcE, coregulates the production of trypacidin.
Subcellular Localization:
Nucleus.
Sequence:
MDSITQLEARANEVAAAARRLAEYCRNARVDGACLPAVVPSEAPRAIREIQRLLLSNVDHLQILLTEPADLVQRLAVQSQLLSCLQWLGEFQVLACLPLTDTVSIADLARLSGVPEAQLARIIRFTITIGFLQEPQRGHVAHSPLSSLFVSRPSLRDAVMFLADSAAPTALQMASATGRFGDTVASETDTAYNIAFDHRDPFYFACEQRPKLQRRWSAYLQHTGGDARDLTQQVLSRVDWFNLNNACVVEVLGPQSQSVTMMLDQLHPMLHFIVQEARIPNGSTHAALHQDVRSVQIRELGGPQRVRDAAIYILNLGPLPHAILSTSVLTELRAHFSVLAANSCAMLILTAGLLLPKPGAVDARVETSVRLHDLSLLQLANDRLMEEDELVEMVHGVKDSVGRLAVVNRLHLPCTTTVALGVRYQAFGHGDSSAKSL
The following text describes a protein:
Function:
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development; [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner.
Sequence:
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
The following text describes a protein:
Function:
May contribute to specialized endoplasmic reticulum functions in neurons.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLGSPASRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI
The following text describes a protein:
Function:
Required for hemolysin production. Contributes to virulence in both silkworm-infection model and mice.
Sequence:
MEILRIEPTPSPNTMKVVLSYTREDKLSNTYKKVEETQPRFINQLLSIDGITSIFHVMNFLAVDKAPKADWEVILPDIKAAFSDANKVLESVNEPQIDNHFGEIKAELLTFKGIPYQIKLTSADQELREQLPQTYVDHMTQAQTAHDNIVFMRKWLDLGNRYGNIQEVMDGVLEEVLATYPESQLPVLVKHALEENHATNNYHFYRHVSLDEYHATDNWKTRLRMLNHFPKPTFEDIPLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMVLLLDDPQKIVRWRAAMFIFDEGNAEQLPALKAHINDNAFEVKLQIEMAISRIENGDEALGSVWKQMANRTI
The following text describes a protein:
Function:
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTVSESSVLDTEVLVGGSAMPNERPGPMEPQSLSQMPEGFPRRSTVANGVRSRASRRFFVVGGALLLSSFAIYEMGAVFSIGGITPLEYLMLALFAINFCWIALAFCSGIAGFLLLLKKPKPNELAQTELHTRTAILMPTYNESPDRVFSAVSVMAEALSQTGHGHAFDWFILSDTTDPEIALLEEQAFLVLRQETHKHSRVYYRRRRKNVARKAGNVADFCRRWGSRYDHLLVLDADSLMESSTITGLAQRMQADPDAGLIQTIPSLINGTTLMARLQQFAARIYGPVIGTGLGWWVQKEGNFWGHNAIIRTEAFMGAAGLPNLKGKPPFGGHILSHDFVEAALIRRAGWSVVIAYDLPGSYEECPPSIVDLAVRDRRWCQGNLQHSRILPTKGLHWVSRLHLMTGIMAYLSSPFWLLLILTGLMLALQAHFIRPEYFTDQFSLFPTWPIMDSDRALRLFYITMVVLFGPKIFGVLLLLKDGKFARSVGGRIKAMFSVLFEVILSALIAPIMMFIHCGAVMSILMGRDSGWSPQRRDDGSMPWLTLIYRHRWHMLAGVMLGYAAILDSLTLLAWMSPALIGLWLAVPISAWTGSIKIGEFFKRIGILATPEERNPAPICIRAQEARAAYQSHIEQPWTLAQLLKDPALMELHLAMVDKQPLRAAGTPIEPVEAIVHVKVHEAQCQQSALALFNRQEMALVLANPLMLRSLQKLPEQFVPEDLVSFC
The following text describes a protein:
Function:
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate.
Subcellular Localization:
Secreted.
Sequence:
LQFVCGDRGFYFSRPSSRINRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSASTTVLPDDVTAYPVGKFFQYDIWKQSTQRLRRGLPAFLRARRGRTLAKELEALREAKSHRPLIALPTQDPATHGGASSKASSD
The following text describes a protein:
Function:
Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFYALYFEIHHLVASAALGFARVAPIFFFLPFLNSGVLSGAPRNAIIILVALGVWPHALNEAPPFLSVAMIPLVLQEAAVGVMLGCLLSWPFWVMHALGCIIDNQRGATLSSSIDPANGIDTSEMANFLNMFAAVVYLQNGGLVTMVDVLNKSYQLCDPMNECTPSLPPLLTFINQVAQNALVLASPVVLVLLLSEVFLGLLSRFAPQMNAFAISLTVKSGIAVLIMLLYFSPVLPDNVLRLSFQATGLSSWFYERGATHVLE
The following text describes a protein:
Function:
Confers broad-spectrum resistance to pathogens.
Subcellular Localization:
Secreted.
Sequence:
MKFSMRLISAVLFLVMIFVATGMGPVTVEARTCASQSQRFKGKCVSDTNCENVCHNEGFPGGDCRGFRRRCFCTRNC
The following text describes a protein:
Function:
Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPQEGQNIVSHLVLDTGGLIKSSATLRKVAQKFYTVPRVLAELKDENSKKNLELWGDSIEVKVPEPEFIKKVSEFAKRTGDYAFLSATDLQVLALTYELEYKNNGGDWRLRSFPGQKKINGPPPVQETASVSETAAVEAKEVAATTEKLEQLNLSNEKSESDNSNAAVEPKEQEPSVDQVEEEDEGDDDDEEGWITPSNLKKVRAREAEADSVAKPVNMKVACITTDFAMQNVLLQIGLNLVSADGLKIQKVKQFVLRCHGCFAIERNMEKKFCRSCGGNTLLKAACSVNSKGEFRVHLKKNFEWKVRGTKYSLPKPVHGSANGKSKKNPILREDQPEYQRAVRYAQRKKERDLMDQDFLPSILTNDRREDLRIVIGAGKRNPNEVRKFKKRQ
The following text describes a protein:
Function:
Dynein-attachment factor required for cilia motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm.
Sequence:
MALPTHLWNKETKELRNAIHDDWKRKAIDSAKKRAAAAHVDYPTFANLVSVAHLKPVERKMSGQEDGETPEHFYRGTAPSWTFDPAGTNKSSNLDDGNAQTADEPPTSLGLQRPRRQLGGREKITDHDVFAKEWRLLNKDTLSQMAFLTGIDSDHYPEIFKVELPPNLLADILATIYTFVKTEKNAAGSPERQQLLRAAFNKAVDEDWIVRMLEEMTKCGRFSLVIGCIGATTHAMIRELISHLNESDWCKTSYEAEDSKRQPSPVSRIHNIASLYRVQIDRQNCMSKSAK
The following text describes a protein:
Function:
Required for male fertility. Plays a role in pollen tube guidance and successful gamete attachment. Essential for the fusion of gametes during double fertilization, where one male gamete fuses with the egg to produce a zygote, and another male gamete fuses with the central cell to produce the endosperm. Mediates the fusion of cell membranes. Not required for pollen tube outgrowth.
Miscellaneous:
MISCELLANEOUS: HAP2/GCS1 family members mediate membrane fusion between gametes in a broad range of eukaryotes, ranging from algae and higher plants to protozoans and cnidaria, suggesting they are derived from an ancestral gamete fusogen. They function similar to viral fusogens, by inserting part of their extracellular domain into the lipid bilayer of an adjoining cell.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Predominantly localized in a perinuclear ring. Redistribution to the cell membrane is mediated by EC1 peptides after their secretion upon sperm arrival.
Domain:
The N-terminal domain (62-541)and the C-terminal domain (583-705) are both required for functional gamete fusion. A positive charge, and not a conserved primary amino acid sequence, is required for a functional C-terminal domain. The N-terminal domain may be involved in interactions with another membrane-bound protein on female gametes, while positively charged C-terminus may function through electrostatic interactions with the sperm plasma membrane.
Sequence:
MVNAILMACILAGIFVGMFNEVDGIQILSKSKLEKCEKTSDSGNLNCSTKIVLNLAVPSGSSGGEASIVAEIVEVEDNSSSNMQTVRIPPVITVNKSAAYALYDLTYIRDVPYKPQEYHVTTRKCEHDAGPDIVQICERLRDEKGNVLEQTQPICCPCGPQRRMPSSCGDIFDKMIKGKANTAHCLRFPGDWFHVFGIGQRSLGFSVRVELKTGTRVSEVIIGPENRTATANDNFLKVNLIGDFGGYTSIPSFEDFYLVIPREAAEAGQPGSLGANYSMWMLLERVRFTLDGLECNKIGVGYEAFNTQPNFCSSPYWSCLHNQLWNFRESDINRIDRHQLPLYGLEGRFERINQHPNAGPHSFSIGVTETLNTNLMIELRADDIEYVFQRSPGKIINIAIPTFEALTQFGVAAVIIKNTGEVEASYSLTFDCSKGVAFVEEQFFIIKPKAVTTRSFKLYPTKDQAAKYICTAILKDSQFSEVDRAECQFSTTATVLDNGTQVTNPFQIPETQPKGFFDSIRILWTKIINGLVDFITGDTCRNKCSSFFDFSCHIQYVCLSWMVMFGLLLALFPITCLLLWLLHQKGLFDPCYDWWEDHFDLDHHRRLLPSRADVVNRHHHHHKHRHHHNHHRRTHQRHKHHHGQDDDVLQKMMLERDHSDSHYYHQLHRVHKDSKQKQRRRAKHGIVLPRDVHVERQRKQRLRES
The following text describes a protein:
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Miscellaneous:
MISCELLANEOUS: There are two HMG-14 proteins in chicken: HMG-14A the major component, and HMG-14B the minor component.
Subcellular Localization:
Nucleus.
Sequence:
MPKRKVAASRGGREEVPKRRSARLSAKPVPDKAEPKAKALAAKDKSENKKAQSKGKKGPKGKQTEETNQEQIKDNLPAENGETKSEETPASDAAVEKEEVKSE
The following text describes a protein:
Function:
Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSLRFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPKRR
The following text describes a protein:
Function:
Plays a role in promoting translation.
Subcellular Localization:
Cytoplasm.
Domain:
Binds to ife-3 using a bipartite interface in the C-terminal domain which comprises a canonical helix which engages the ife-3 dorsal surface and a non-canonical helix which engages the ife-3 lateral surface.
Sequence:
MLHNYDDFGGGKMQGAPQVPRNTLLSVDQQLQLMNTINNMVRASQFTSQLANTIFTLCAQLKTSGSMLEQSHKNELNKVFTSLRQACCRDNGQLGTPCRLKIMELVELRAMNWRTNLAHSQYYVNRPEGQHDPAPTVGIPPSATSPPTQVTSSVTSPVPSSPQPPMQFVPQNPMMFQDPMAANHNAGGIFFIPAASTWMNPLMPMPPNPFLPHSMIPPDHQMFLRQRSLNKKPNNLMNKTLQLRHEMIIRNSDSGKIMGVKGRRVAAVEQLTNTVISFQKVDSKSKERTLTITASTMEDIERAKDMIIDTIRRNMSPMRTDMSIPPPNQYSGMSSENQSIPSQQNTANIDEDDDDDDEDIKLEQTSDGKLTFHCDDPELLAAAQEALSAYLRVRARPSAEEREKKKERRKSMPLQQTARDQQEPVMLKPAKTFHGSTPNLADGLAATTTVVVASIPQPMVPNVHASGDNPIRYNRDTLMTARDTKRAPIPDEMLQEINRVAPDILIA
The following text describes a protein:
Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular Localization:
Nucleus.
Sequence:
MASAYKLSEGALQTIMYGGEVIDPLVQILGTKKMSPGGSDSSSRLRLMISDGLHKVNIAVFTVPKNDQTLPHVLEQVFTIIKLKRYLSNVIKNKNNIDARVIAILELEVVARGEFVGQIIGNPVSLSDSETLTQSSDVIKRNECINGSFSSKTISPIASLNPFHNNWIIRARVVNKTNVRNWSNAKGEGKLFSIDLVDKGGEIRCTAFRDLVDKFFDRLEVDKVYYISKCQLQPINRQFCSLKHQFEMYFTPETIIEPSYDDNEIIPQITYNFTTIDKVAVMEAGTIVDVIGVCKTISELQSFVAKSTNREMQKRQLVLVDQTKTAISLNLWGSQAESFAVTGNPVILVKNAKIYEFRGAKSITLMGTSLLKIDPEIRETHILRRWYHSEGNQVEITNVSHRNGYGSTPWLTFKEARQQTISEKPLYYQTFGTILLVRLDRAVYKSCPNADCQKKVLDLENGMYRCEKCNREFPNFKYRLLVSMNVADSSSSQWVTVFSSEAEKILGKTAQEIGELMETDPDTVANMFEEAQFKQFIFKCRAKIETYNDEQKMKTVVVTVAPVDYEEYNAYLVDRIEKFTGVPCN
The following text describes a protein:
Function:
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Sequence:
MGGGRMLPILGAFRHHICLRTSSLTASTPRAFTSQIIKSPSLLSLDLSDSWSSPSKQSEESYTPEEYSNNCIAKIIDGKAIAENIRSRIASEVSRMKELIGHVPGLAVILVGQRRDSQTYVRNKIIASEEVGIKIKMISLPENCDECEVCNVLCRFNKDPSVHGVLVQLPLPQHLDEAKILNVINVEKDVDGFHPVNMGNLAMQGMEPLFIPCTPKGCIELLVQSGVEITGKKAVVIGRSNIVGLPMSLLLQRHHATVTVVHDFTKKPEKITREADILVTAAGVANLVRGSWLKPGVVIVDVGTNPIEDRRSEHGYRLIGDVCLEEAIRTASAITPVPGGVGPMTVAMLLYNTLLSAKRAFNFT
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MSILKFKSILPKLSSGILRNTLLPTKIVPLKILCKYSSGSNLQTQENEHYDRPKLLNVHLPNTSEPLKLHPIWLRDHCRCPECYNDVTCQRNNDILKLSDQIAISTYSQSDDLLHICWSDGHKSSYSIPWLVSNTYDGKYKALQEETDRLTTWDGTTVNLLGLEPISHQRLMSDDKILREIYRRVIQYGFVKIEQVPPTKLDTSAVIERICRMSHTVFGKFWETGTNFDHKDTGYLNGYLEAHTDNTYFTEAQGLLVFHCTHFDGTGCESFLVDGFHVAKQLKQLDPSAYGYLSKVNMESEYIEPGEHFSSWGPIFRHHPVSHKLEQIRFNMLDRSPLSSIPQEEVGTHYRYLKTMATLVKKKENEYRFRLSPGTVMIIDNWRLLHGRESYQGERVLRGCYYSRSDFMSKARHYGIIS