lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MSLSQESGAHHDPQDYPVVSDEEDEIDILGEDDSCSLKSHFYLQPTHSEMGDSGILSPSKLSCTESESDSSGESEGGTSKDSPATPSGGKAKRALVKPPYSYIALITMAILQSPHKKLTLSGICDFISSKFPYYKDKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPASEDMFDNGSFLRRRKRFKRHQQEFFKDGLVMYNPLPYYRPYSTIQPQQVLQQTPVACMAIPENLTMPTHLAPYPDIKRKVPYPDQGVHRGFEALDADNHPNKSQSKCSFSIENIMRKPKEPEPSFSTFNPHWNYNHLLQRPNSCLLPAVLNLSTGPLLSNAQGTRQYNLIKFPGCY
The following text describes a protein:
Function:
Histone acetyltransferase that acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation. In addition to histone acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and is able to mediate histone crotonylation.
Subcellular Localization:
Nucleus.
Sequence:
MVTRRRLHHPEVEQVSKRQKVDKAESKNKKHADVAAERGEQSTEDHEDESQDKKDKKVVGDNRDEDEEVSPNGQEAAEDNDDRKDKDAKEKDTETNDEGTEKSHTDVNDDDDDVDESKEEDAAAAVDITKEKKDEQESDNKTEEKKVQENEEEEEEDENKNDEDVEELGSTEPVDDEKKGLVKFEFDGVEYKFKERASVIEENEGKIEFRVVSNDNTRENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYKPFNKRQFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSDIRYFLTYADNYAIGYFKKQGFTKDITLDKKVWMGYIKDYEGGTLMQCSMLPRIRYLDAAKILLLQEAALRRKIRTISKSHVVHPGLECFNDIENIKPIDPMSIPGLKEAGWTPEMDELAQRPKRGPHYAAIQNILVELQNHAAAWPFLRPVNKEEVPDYYEFIKEPMDLSTMELKLENNKYEKMEEFIYDARLVCNNCRLYNGENTSYYKYANRLEKFFNNKVKEIPEYSHLID
The following text describes a protein:
Function:
Prenyltransferase that catalyzes reverse prenylation at position N-1 of tryptophan-containing cyclic dipeptides. Accepts only dimethylallyl diphosphate (DMAPP) as the prenyl donor but shows broad substrate specificities toward its aromatic substrates. Also shows tryptophan aminopeptidase activity with preference for linear peptides containing a tryptophanyl moiety at the N-terminus.
Sequence:
MDGEMTASPPDISACDTSAVDEQTGQSGQSQAPIPKDIAYHTLTKALLFPDIDQYQHWHHVAPMLAKMLVDGKYSIHQQYEYLCLFAQLVAPVLGPYPSPGRDVYRCTLGGNMTVELSQNFQRSGSTTRIAFEPVRYQASVGHDRFNRTSVNAFFSQLQLLVKSVNIELHHLLSEHLTLTAKDERNLNEEQLTKYLTNFQVKTQYVVALDLRKTGIVAKEYFFPGIKCAATGQTGSNACFGAIRAVDKDGHLDSLCQLIEAHFQQSKIDAAFLCCDLVDPAHTRFKVYIADPLVTLARAEEHWTLGGRLTDEDTAVGLEIIRGLWSELGIIQGPLEPSAMMEKGLLPIMLNYEMKAGQRLPKPKLYMPLTGIPETKIARIMTAFFQRHDMPEQAEVFMENLQAYYEGKNLEEATRYQAWLSFAYTKEKGPYLSIYYFWPE
The following text describes a protein:
Function:
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein; The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
Subcellular Localization:
Virion membrane.
Domain:
The large envelope protein is synthesized with the pre-S region at the cytosolic side of the endoplasmic reticulum and, hence will be within the virion after budding. Therefore the pre-S region is not N-glycosylated. Later a post-translational translocation of N-terminal pre-S and TM1 domains occur in about 50% of proteins at the virion surface. These molecules change their topology by an unknown mechanism, resulting in exposure of pre-S region at virion surface. For isoform M in contrast, the pre-S2 region is translocated cotranslationally to the endoplasmic reticulum lumen and is N-glycosylated.
Sequence:
MGGWSSKPRQGMGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWDFNPNKDHWPEANQVGAGAFGPGFTPPHGGLLGWSPQAQGILTTLPAAPPPASTNRQSGRQPTPISPPLRDSHPQAMQWNSTTFHQALLDPRVRGLYFPAGGSSSGTVNPVPTTASPISSIFSRTGDPAPNMESTTSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGAPTCPGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLLPGTSTTSTGPCRTCTIPAQGTSMFPSCCCTKPSDGNCTCIPIPSSWAFARFLWEWASVRFSWLSLLVPFVQWFVGLSPTVWLSAIWMMWYWGPSLYNILSPFLPLLPIFFCLWVYI
The following text describes a protein:
Function:
Transcriptional activator involved in cell elongation. Regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing CIB5 show increased hypocotyl and cotyledon lengths and increased flower size.
Subcellular Localization:
Nucleus.
Sequence:
MSDKDEFAAKKKDLVNTPVDLYPPENPMLGPSPMMDSFRETLWHDGGFNVHTDADTSFRGNNNIDIPLEMGWNMAQFPADSGFIERAAKFSFFGCGEMMMNQQQSSLGVPDSTGLFLQDTQIPSGSKLDNGPLTDASKLVKERSINNVSEDSQSSGGNGHDDAKCGQTSSKGFSSKKRKRIGKDCEEEEDKKQKDEQSPTSNANKTNSEKQPSDSLKDGYIHMRARRGQATNSHSLAERVRREKISERMKFLQDLVPGCDKVTGKAVMLDEIINYVQSLQCQIEFLSMKLSAVNPVLDFNLESLLAKDALQSSAPTFPHNMSMLYPPVSYLSQTGFMQPNISSMSLLSGGLKRQETHGYESDHHNLVHMNHETGTAPDHEDTTADMKVEP
The following text describes a protein:
Function:
Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
Sequence:
MPRPVLLIHGGAGDIPDSRIAGKFKGIKEALRCAWGSLVPASGAKGGALDAVETAVRSMELDENFNAGYGSCLNTDGQVEMEASLMEGQDLRAGCVTLLRDVMHPITVARRLMEKQRHTFIGGEAAQELALSTGSERLPANALVTEGARFTLQQFKEQLTQGKDPFFARTELAAEQKTDPSGETVGAVAMDHNGQIVVGTSTGGITGKWPGRIGDTPILGSGTYADNARGGVSTTGHGETIMRYNLAQRILAAIEHKGMSAQAAADQECREMTRRIGGTGGAIVVGHAGDLGISFTSQRMAWGYIQDDTIFYGIEGQVVHQEPLS
The following text describes a protein:
Function:
Catalyzes the formation of putrescine from agmatine.
Sequence:
MEEHFIDLSKFMMANCPYEEAEGVIFSIPYDETTSFKPGAREGGNAIRTASWGLETYSPILDRDLAELKYCDLKDLDLYGSQEEIFGTIHSVSREILKENKKIIVFGGEHSITYPIIKAVKDIYDDFIVIQFDAHCDLRDEYLGNKLSHACVMRRVYELTKNIFQFGIRSGDKEEWDLARKNNLYLKMDLMNKDDLEYIKSLDKPIYVTIDIDVLDPAYAPGTGTPEPCGFSTRELFNSLYLLEEVKDKIIGFDIVEVSPIYDIANITAITAAKIARELMLMIL
The following text describes a protein:
Function:
Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MKFMAVFSLALMAIASVHTATTDHVQHAIRAGLVPVRGVNLGGWLVVENWINSKDPLWDGVPSTVSSGGEMQTMRYLGHEVGDARFQTHWDTFITEEDIANIARNSLNTVRVPIGWWILGYDIHDPSNQQEYKTFAPGGLYFLDRLVQEWAIKYNVAVLIDIHAAKGSQNGNDHSSPPDPGQAYWSQYQENIDNTLEVARFFASRYRYTPSFLGVELLNEPTSVDVTKLKDYYLRAYDAIRTTTGNDCILVTSPILWEQNAGTGSDWEHFMPSPAYTNMWHDWHKYLIWGFEGQTADWIMNEGVALIAADIAAWTGAPLVMGEWCVAAPASAVFTDVTLKQYAYNVITTMEAMKGGWTMWTWKQEGNNPRPDGQGGWSMKDLINDCIMDPKWWDNTSTVCP
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGVTWVFEAEQTAKSVERLLESIGGDLHGTFIVDVTPFNPPTPSSDYPSNVVMHHSKCPQSTFSICPKDTFKKSPKAVCDRGFDLILSKLSSGLIADNAGKIEIIGNEYSLYKDWMIRVGTATQGTTVKGVVVEIEYDPSIIVIQCKDMMIEFVKSVFNKYHETLPEIFKITEKPESYTALDTMWQYLGIATKLRKKT
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.
Subcellular Localization:
Cytoplasm. Golgi apparatus. Note=Associates with the Golgi complex.
Domain:
The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes.
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MFLRAIGRPLLAKVKQTTGIVGLDVVPNARAVLIDLYSKTLKEIQAVPEDEGYRKAVESFTRQRLNVCKEEEDWEMIEKRLGCGQVEELIEEARDELTLIGKMIEWDPWGVPDDYECEVIENDAPIPKHVPQHRPGPLPEQFYKTLEGLIAESKTEIPAATPSDPQLKE
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MEESHDFQFVLPLNASDLINSSGDQYYVKEIFGAQEIPAKLQECKRKVHLGDPFYIFEHFDLYYSIIEARGSDGASAQNLMRSFDLLYLTVEKLFQDLQPLLTASEPMSNQQRNSYLNLTKMTLFLQVSTVKKINNSVQQAMRDQQLNVQKKRAKPSEGLEQFPNWEVKRGKFLVQLFNVLQCPLEKLWSPPVAEEDFINLLCDPCYRTIELLPLRMDNKHVFDTIFQILGTSIKRFNQAMTFPVRILQILRGTEHAAHSVAAGILLLHEEYGISSVFSILIKSIVDALRMDSSDSSVSKHFSNFLAEFSNIAPSLIVPHLEKLAEDLLDCQSHTLRNCVLQIIGDTVVSELTSEDLSEELKEVRNEFLEHLMAHILDISAHVRSKVLSIWHHLKTQHAIPLNFLTRVLEEAIGRLEDKSSLVRRAAMHLIKSALESNPYSSKLSIDELRAKHEHEVQAMEKLNEVLEEERKQEEKLNDEFSSLAPELLPFIEENLTEFPDMQFDKEESDETLMERIIPLMREKNYKDVIVLVRKVDFLAGNQNMSSLLKHEEHCVYVLALLKTYHLLAAGFKQSSEEMLQQIKTVQFLKDSIDFAVLMTSAFPKLHEMLMSKTNTDVFEAVDLFTTGYMFGIHGTESGMQRMLQLVWSSDKEKRDAVSDAYKRVLFSTDQTGRAHAIKVVQNLSKFLSEIEYGHYTALESLMTEWVLGGDIDAAVIQVLFERFTLKLEGTTSNESRLSLQLLIMASQSKSSIVSANTAIIEDIAVGERVRRDPRIFTSCLQLLVNSIDANNTAKYYKRQNSDAEFVGKITRLFLDFFFHRSLYDFDALAMSVFEYFYRMCQAPDVIAQQLVTALLKQFNESWLVKEAAAIVPSPDKADTETVPDSQPLEIPHSQTLTPTQTQADSQSQMQGTLIPVYLVSRLIFCIGYMTIKEMIFLDMDIYNNMKYRDELTALEERKNRNQQAGSSHNAARLTLNMSAMEVRKRLSGVAAEPQQEPDDDLVGATAEDNIAEEIHGICEDMLLYNPDALLSKLAPFIIEICKRPGEFGDPTLQQAATLALARLMTVSSRFCESNMSFLMNILNLTKNIRIKCNTVVGLSDLTFRFPNIIEPWTGHFYAQLHESNTELRLTAVKMLSHLILNEMIRVKGQIADMALCIVDGNEEIRNITKQFFKEIANKSNILYNVLPDIISRLGDINLNLDEDKYRIIMSYILGLIQKDRQIETLVEKLCLRFPVTRVERQWRDIAYCLGLLTYNERAVKKLMDNMQHYRDKVQVDEVYQSFKLIISNTNKLAKPELKAVVTEFENRLNECLQVNPDTAAQGDQESTPEGQGNRTRAAPRTKKGGRKPAANRNNTVRGRGRRARRDSTSEESFSSSSSD
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MSNQSKRVTVRIEHSKNTFFEKVLKFQHQEQEDRKLKYVLHKAHENLRKCPFEILTIVDLKNVQGIGENIALKLEETWNVACRENNGQDPTLRSIKKFTTDDYRRFLTNRKSTTERMKDAKRLEKQKSTKTIVDIENEFESDGDDDKQPSVPLTKTKSFQVSKPVQPSLIRSQSGNLSSSSSTSSSSSNSSDPLSFRLLTCRPFEQPTVYLIADNREHRNNPRFKSVIEHLVKKEDIRVDIRSLSVGDYIWICRKIDGTEIVMDWVVERKTWDDLQSSIRGGRYDEQKGRLNMAPMKNRVYLIEAQHKGDVACEQAVASTLSNGGYLIQRCSDTRDTAAFLKEVTIRLQNKAAIEEISGVPFSQLQNLLQKKKAETVKEAWVRQLMVCPGMSQNRAEAIADRFPSMVSLLSYFRANGDDAPIRLLQLLPQLTRPITRNLFKFFVQ
The following text describes a protein:
Function:
Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.
Subcellular Localization:
Cytoplasm, cytosol. Note=Located just near the plasma membrane in close association with filamentous actin.
Sequence:
MKKIFGFRSKGPSPLGPSARPRSNCVGFGRESASGSHVPRYHIHDKDMGKIHKAASVGDVAKVQHILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAVDQLGSNRQMFEYDGKRLQRSENSNPVDNGSEDGSLTRSYNTPGPADSWPTSDEEDYNFDNKNVPKINLTELWTAAQQSRKNQTKCGFEELDNGARFDDSDSPSESEDAIEVEPAPSVRVQTLSPSRQSPDPVEGATELAIEGEENGTDVIESASQEQPNHDNLTRADGWHKSNKSEMMSALGLGEDEDEDSPWDSESISESVSLKDVGHFSGTADQTGKRRAHGQIEDVTYIPSCMSGSRNFKMAKLEESRNVGLPVAHMEAPRKYVIMEPTIERRAPVLNKTETVGMTDAQTFKSEPESVSREEQTRLSGSEDSQQKVEEKRKYKNNEAEPSGNLYSGAADGGADVKPQSGDTENQQSPREGSEGRGSGPALLMKEAKKMENEKWVSREPARTAMSERTGLPTGGWPQMQDGSCWSDTDQSEARPTKKTSSKHNKDSGQTAAVDNLDDFTESSETASEDHELQGPDSESILCAIEHLRLECKDTASLLKIRDAVYSYKRLIELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTMEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQNARMLQDGILASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANEKNDNLQRMVKLNMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELMRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVEERARQDLVEKLKQVNLFLQAQAASQESLEQLRENSNASVRSQMELRIKDLESQLYRMKAQEDFDKIELEKYKQLYQEEFRARKSLSSKLNKTSEKLEEASSKLLLEEQQNRSLLSTLSTRPVVECPCVGSLHNSLVFNRTLIPRENIVVPTSGLQPSNKRVEIYLTKMHQELEKSINRELKEATAELESEFCRVSPLGSATKASQDQLSDASQEFIDILKKKYMI
The following text describes a protein:
Function:
Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth. Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome. In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program. Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis and thus mediate cell proliferation. During gastrulation, negatively regulates stg to delay mitosis in the ventral region of the embryonic mesoderm thus allowing invagination to be completed before cell division takes place. Delaying stg-dependent mitosis during bristle development and in migrating germline pole cells also arrests their cell divisions, whereas in cystocytes it promotes their cell divisions. Involved in the regulation of the mid-blastula transition; promotes the destruction of twe resulting in the cell cycle arrest in G2 of cycle 14 which delays mitosis and thus reduces cell proliferation allowing cell fate specification and morphogenesis to take place. In germline cells, blocks border cell migration during oogenesis by binding to slbo/C/EBP and promoting its ubiquitination and degradation by the proteasome. May function in a negative feedback loop with slbo to coordinate proper border cell migration. During tissue growth negatively regulates insulin signaling by binding to Akt1 and blocking its phosphorylation-dependent activation. However it may also function downstream in the insulin signaling pathway, acting with Akt1 to direct foxo degradation. Essential for the proper formation of operant place and aversive olfactory memories.
Miscellaneous:
MISCELLANEOUS: 'tribbles' is named after fictional small round organisms from the Star Trek universe that proliferate uncontrollably.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cell cortex. Note=Weakly cytoplasmic. In the main body follicle cells, strong nuclear accumulation at stage 10 that decreases to low levels in the cytoplasm by stage 12. In border cells, high levels of expression detected prior to border cell (BC) delamination (from stages 7 to 8). At stage 9, expression levels remains high in BC as their migration begins but decreases throughout migration. By stage 10 levels are low in BC nuclei when they arrive at the nurse cell/oocyte boundary.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MDNSSGQNSRTASSASTSKIVNYSSPVSPGVAAATSSSSSSSSSGMSSSQEDTVLGLFTPKKEFPNAKMLQTIREKLMTPGGACDLLALGIAAEPTDQQPVKLIQQRYLISAQPSHISAAVAAKTPASYRHLVDLTASNLRCVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWLREQRPFHMYLPVDVEVAEDWSDAEEDEGTAADAMDDDEEGLCPLGDKHEYEDIGVEPLDYTRSTLQMAQNANGLSTEPEPDTDVDMG
The following text describes a protein:
Function:
Displays transglutaminase activity (TGase) in vitro. Plays a critical role in the viability of P.aeruginosa. Might contribute to an essential function linked to the cell wall.
Miscellaneous:
MISCELLANEOUS: Unlike Guinea pig TGase, TGase activity is not affected by EDTA addition, suggesting that TGase activity is Ca(2+)-independent, similar to members of the bacterial transglutaminase family.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The transglutaminase activity is contained within the periplasmic domain (180-544).
Sequence:
MNAIPRVALVWLLVAQVLVILPHLAYMPLWIAAMWLGCAAWRVQVFRMRAGYPRAWVKLALALLAGAGVWLSRGSLVGLDAGAVLLIAAFILKLVEMKTRRDALVLVFLGFFAVVVGYLFDDGFLAALYSLLPVTALLAALIGLQQSAFASRPWPTLRLAGGLLLQALPLMLLLFLFFPRLGPLWSLPMPGNKGVTGLSESMAPGDIAELGRSAELAFRVRFEGALPPREQLYWRALTMERFDGRRWAQAPQWSGEDALHWQKRGPELRYDVIMQPSSQPWLFALDVAQTDQTDTRLMSDFHLQRRQPVEQRLFYRVSSWPQALRESSIDPRTRWRNLQLPMHGNPRARALADELRQAHAQPQALVAALLQRFNHEPFAYTLKPPATGADGVDDFLFDTRSGFCAHYAGAMAFVLRAAGIPARVVAGYQGGELNPAGNYLLVHQFDAHAWVEYWQPEQGWLSVDPTYQVAPERIEQGLEQALAGDSEYLADAPLSPLRYRGLPWLNDMRLAWDSLNYGWQRWVLAYQGEQQGAFLQRWFGGLDPTRLGLLLGAAAILSVGLLALFLLKPWQGRGDLRSRQLRRFERLLEMHGLRRSPGEGLRSYGERAARVLPAQAPAIAAFVGAFEAQRYGHGGADDPGLRLRALRRALPWRLVRTPTRDGRGEEQA
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
Subcellular Localization:
Cytoplasm. Postsynaptic density.
Sequence:
MSSLLENPLQAVLYLKELTAIVQNQQSLIQTQRYRIDILERRLEDLATENRQLRDSGSHHRHPPRYHPPPPPRTSSLPRTSRAETPPVQNQTPQQQQQQISPLDMQLVPAGPSTASPDSADEDEELQDPCCRSLVPQTPATLCRAVGLPRASESQTVLHQFCCPAPEAPEGESSTTCSSSVPAAGEEQKEEKRDDQPDVPPCSHPPEYELSPDLKQKQIEELEQKYGGPLISRRAACKIQTAFRQYQLSKNFQKIRNSVLESGIPRRMSVRRVRVQRDGFSAERALMEGCSIMGIPLTHSTSLPVTTTTTLTHLEDTFSEQVQSLARSIDEALSSWSTIRDGEGEKSSAAPPSGSHPEGLLMDPSSLQEATQSGCGESIPRSASKLMMAFRDVTVQIDNHNFRLSSSMLESVSLGNGVAKETVSEPQIGGQIAGQTTLSTAGDPEFPPPPPSEEEKENQQPIGLDTVTTGAGLEGKQTNQVAPEIAENSSDPISSSSTSTSACETMILSLPRPHCQNTPCGTLSTDIARKRLYRIGLNLFNVNPDKGIQFLISRGFIPDTAIGVAHFLLQRKGLSRQMIGEFLGNSKRQFNRDVLDCVVDEMDFSMLELDEALRKFQAHVRVQGEAQKVERLIEAFSQRYCMCNPDVVQQFHNPDTIFILAFAIVLLNTDMYSPNIKPERKMLLEDFIRNLRGVDDGADIPREMLAGIYERIQQRELRSNEDHVTYVTRVEQSILGMKTILSVPHRRLVCCSRLYEVTDVNKPQKQASHQREVFLFNDLIVILKLCPKKKTAATYTFCKAMGLLGMQFHLFENEYYPHGITILSPFSSEKKQVVSFCSQSADELLKFIEDLRESIAEVAEMEQIRIEWELERQQVVRNQTNKNGTQLDIHAGPSSASGDDFYEKAGSNTVEVSIHNRLQTYQLSSPLAPPSAQQRLAVLPSPAPDSALTISPDTLIQCQQIVKVIVVDSAGRGHVEAFLSHNPAHRLIQSAVSTPTRSREAGKQQQQQQQPPLPPPPPPYHHPHQFCPPTPPPPRHLLSQRRYSSGTRSLV
The following text describes a protein:
Function:
Plays a role in the process of neurogenesis.
Sequence:
MNKLRQSFRRKKDVYVPESSRPHQWQTDEEAVRGGKCSFAVRYLGHVEVEESRGMHICEDAVKKLKTDRKVFKGFFKKAGKKAVRAVLWVSADGLRVVDDKTKDLILDQTIEKVSFCAPDRNFEHAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDANRTTFTREGSFRVTTATEQAEREEVMRQLQDNKKDSDLVISSSSGGSCNPVVVTLAGPNGSSSPPLPMAPLGLQDGNPHVIPRRHAPVEALARQGSFRGFPALSQKTSPFKRQMSLRMNELPSTMQRKSDFPIKNTVPEVEGEVDSISSLCTQITSTFSGPPEDPFSSAPMPKPASSPQSPAAPVNGAVPAFPPPSVTVTTAANSPVLPPPPLPVRETNPWAKAPNTAPAHAAHTGSEWPSPSPSTGALPAVSATLSTPASAHKRTPSEADRWLEEVTKSVRAHQPAPTARTSTPPAQQPFPAPVPVPMPPSAPFMPPIPPSAVPSVPPRQPAFHAQAPVSFPVSNGIPYAQPTFPVVGITPSQMVANVFGSATQTQPISVPVPVAQTQLQSSPFSTPPATQFEPQPVCSPFGKPLLPPVPNTVVLQPPPKPSPAFNGANSWAAAASAGQAGANPPQADAFEAQWAALESRSQQRTAPSPTNPFSSELHKTFEIQL
The following text describes a protein:
Function:
Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.
Sequence:
MAASWSLLVTLRPLAQSPLRGRCVGCGAWAAALAPLATAPGKPFWKAYTVQTSESMTPTATSETYLKALAVCHGPLDHYDFLIKAHELKDDEHQRRVIQCLQKLHEDLKGYNIEAEGLFSKLFSRSKPPRGLYVYGDVGTGKTMVMDMFYAYVEMKRKKRVHFHGFMLDVHKRIHRLKQSLPKRKPGFMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSGIDYRKRELPAAGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTVADCTFEELCERPLGASDYLELSKNFDTIFLRNIPQFTLANRTQGRRFITLIDNFYDLKVRIICSASTPISSLFLHQHHDSELEQSRILMDDLGLSQDSAEGLSMFTGEEEIFAFQRTISRLTEMQTEQYWNEGDRTKK
The following text describes a protein:
Function:
Transcription factor that regulates the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20 as well as SWI5 and ACE2, transcription factors required for the subsequent temporal wave of cell cycle regulated gene expression in the M/G1 phase interval. Involved in HMRa silencing. FKH1 and FKH2 associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. FKH1 and FKH2 function also in controlling yeast cell morphology by preventing preudohyphal growth. Acts as a rate-limiting replication origin activator via its interaction with the origin recognition complex (ORC). Plays a transcription-independent role in recombination donor preference during mating-type switching through binding to the recombination enhancer (RE), a 700-bp cis-acting element that controls recombination along the left arm of chromosome III.
Miscellaneous:
MISCELLANEOUS: Present with 1720 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Note=Relocalizes to the cytosol in response to hypoxia.
Domain:
The phosphothreonine-binding FHA domain is required for the interaction with MPH1 and controlling recombination donor preference during mating-type switching.
Sequence:
MSVTSREQKFSGKYSSYTAQDRQGLVNAVTCVLSSSSDPVAVSSDYSNSLSIAREVNAYAKIAGCDWTYYVQKLEVTIGRNTDSLNLNAVPGTVVKKNIDIDLGPAKIVSRKHAAIRFNLESGSWELQIFGRNGAKVNFRRIPTGPDSPPTVLQSGCIIDIGGVQMIFILPEQETIISDYCLNHLMPKLLSTYGTNGNNNPLLRNIIEGSTYLREQRLQEEARLQQLDHLHTPLSSSSDVNPIGDPHGDTIMMEEDEEDENYTRGGIRPNTYTSSSNNAVTNGNVPHIENPSDLSLDENRYIKPPQSYASMITQAILSTPEGSISLADIYKFISDNYAFYRFSQMAWQNSVRHNLSLNKAFEKVPKRAGQQGKGMNWKISDEVRRDFLNKWNAGKLSKIRRGASVTRQLQLHMSKFGEIPAPESSSIDPRGIKAQKVKKSLQATSSILGESAPQLQRTQLTGQISTTTSMDVTTNANVNNSSLS