lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short transcripts are synthesized and released before proceeding to the processive transcription of long RNA chains. Unwinds the double-stranded DNA to expose the coding strand for templating. Participates in the initiation of viral DNA replication presumably by making primers accessible to the DNA polymerase, thus facilitating the DNA opening. Also plays a role in viral DNA packaging, probably by pausing the transcription at the right end of concatemer junction to allow packaging complex recruitment and beginning of the packaging process.
Sequence:
MNTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTAFQFLQEIKPEAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWSSWHKEDSIHVGVRCIEMLIESTGMVSLHRQNAGVVGQDSETIELAPEYAEAIATRAGALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPAIEREELPMKPEDIDMNPEALTAWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAINGTDNEVVTVTDENTGEISEKVKLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQFRLQPTINTNKDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQLHESQLDKMPALPAKGNLNLRDILESDFAFA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPPRIPNAPSSLLLQSSACSGSSSRCTASRLPTWASSCSSSSPQSSQPTTHQQQCSSFSTTAPAHVQSVRRQKMFSWLDKKGSAYKEHTRQGPNLLGGQGKDGLAVPFPNNPYFKSQPVLSEGSREIIYQDVMEKGLPIKAVSAKYNVDVRRVAAVIRLKEIEKRWIKEYKPLARPYARAVMKMLPQTVLGGPDQKPHESINDVHVHSYTTQQLFVPVSESREFTREDAAKAFGDHILPVDKKLRVPELIEFQKDLLKEVPLQEANRKFLNATAASEAKIAEREAKRRQAVEDAITRVKTDRFEFRFQEFNAENVGHDGRDRNAVGWRYGVPFPDRKRSQIKIPTKVE
The following text describes a protein:
Function:
Transcription repressor that represses many genes including ureABC and tnrA, during nitrogen excess. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site.
Miscellaneous:
MISCELLANEOUS: The amino acid sequences of the N-terminal DNA binding domains of TnrA and GlnR are highly similar, and both proteins bind to DNA sequences with a common consensus sequence. In contrast, the C-terminal signal transduction domains of TnrA and GlnR have no homology.
Sequence:
MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEGNRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSDDELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MEVACSVQSLRSVRNIHRISVWNAAQLALLSFREQEDMRNIIDGMGRLSAQAQHLRTPITDYGRLKAGSHTLYLCTTGVQGKPELVLAKGMLKVGRKNLFIRKDNGQLVEMSPLCVLDFYVHESCQRMGLGHELFETMLSKEKASARELGYDRPSSKFHSFLEKYYHLTEFLPQANQYVVFKDYFNVDQTNSNGACALDERGRSPGTGFLESSGKKDKVLHGRRATVSESSNSDAEFCPARKSERDVKGSHDVGVADPCTVQQQPPSGRRQSRHHMANLPVVNKVPCHSNSVDTQRHVPSLSSSTAANDRDSSGVRKHAAAAGEYKPSIHGRRSTLSGPSKSTDARKASEKAYARYPSPPCLPKTLENEPKDDSCCNPYKFPRTESTRSRIFHEDCFVQIARPAAPPLKCPFWTEDAPAFRTKNSDTIDKINLLASAPVSFENTRSCYHAGMKGYGAAEAMGWSSSLIK
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MAFGKFFNTITRTLILPQIKSSSPLLQNRFINPHLRLYSSDKSKDKGGKKPNNRGNKSFRHNYSEEVEAAVNHQILSELNASMVYLSMFCYYGRTDIALPGCQSYFRAMYQEEQDHALEFIQYQLMRGGQVTLFPITVPEDGNWTDITIAIGVALGLERRVKEQLEELSKLAECHNDKQLVDLVDSKFMKEQNESICELGRLLTKAKRLVDTGGVGRHLFDQEILKFVAKRHPHVQLPFDNI
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MILTPLKHSGIHLSSGTLQRRNIPLDAVFIDSIPSGTLTPVKDLVKYQKSSLKLKVHQNNQLLETTTSNNKNIFQSTMLSGTTPLNRSFDVSVIKPNMDRLKNETIYESPQKIFQRMKEKVQRDKEELSRISSMLASPKCEHKVFPLNRDKETRLQHTYICEEKEKSFQSNNPSLEDPPVLNQEQKYVLASCISRKALTRAQFGRQVLHSKESPVKTTVSKKNTFVLEGIDSTYEKFESTDVSTISTICVPIKNHSQLTTSNNDMTTENTAKEDITEQNDKTTSRRTVLQDPIRNTSEIICANPRLNSTISGQPQRKLTKLETIVGEVKKYQVVKLQEWMIKVINNNTAICVEGKLVDMTDVYWHSNVIIERIKYNELRTLSGNTYILKGMLDQASMKEAGYPCYLIRKFMFGFPRKWKEYIDDFLEQLRAEEKNKNKTRQKTARFQEKQKSIKNDAEDKQTDILRKASVTYDLNDDSLERTEVLNVPIDPLKSLEQPTSNKERHPPLGQKEAYVLMTPLRTTKLIEQRCMEHSLSIEGVRGFLKANHQEESESDVHGMSTSKSSETFEHSVDYKGSSKEDCSKCDIITVTHSIPIPCPKSKQMFTNDFKKKNKLPSKLQKTENQIDVSLYSQSSSHLSSKENEIEVKGKTRARNKKQRLDQQRKNTNYITKDILISESSGESGSYVTPKKPRSSAKESHYKSDITKDFLIEVKASDTTNGQLLDHQPGSTDDGEWNEQELQKLHRAFASLPKHKPGFWSDVAMAVGSRTADECQKKYTEEPQGRGSRKYVSKKKQANFKVQNGEADDADDKQTVKITARVGTLKRKRQMRDYLEQLPKDNHDDFFTATPLQKQRIQLPSFQYSQDDDFLLAMDRNPVSPASITSTLTSTTPKCQHVSPSMLASINRNDCDKYIYHMQKNAKKYGKSNGNLVWGNIRKKTVETDLSSPTPTRKALFNKDLGENTDIAKYFIDDRESDEEEKDYYFSSSDL
The following text describes a protein:
Function:
May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.
Subcellular Localization:
Nucleus.
Sequence:
MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNFVDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTLPFPVYSNGIHAAQTLERKED
The following text describes a protein:
Function:
Also deaminates threonine, particularly when it is present in high concentration.
Sequence:
MISVFDIFKIGIGPSSSHTVGPMKAGKQFTDDLIARNLLKDVTRVVVDVYGSLSLTGKGHHTDIAIIMGLAGNLPDTVDIDSIPSFIQDVNTHGRLMLANGQHEVEFPVDQCMNFHADNLSLHENGMRITALAGDKVVYSQTYYSIGGGFIVDEEHFGQQDSAPVEVPYPYSSAADLQKHCQETGLSLSGLMMKNELALHSKEELEQHLANVWEVMRGGIERGISTEGVLPGKLRVPRRAAALRRMLVSQDKTTTDPMAVVDWINMFALAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIREVNANSLARYLLVASAIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPAQVCIAAEIAMEHNLGLTCDPVAGQVQVPCIERNAIAAVKAVNAARMALRRTSEPRVCLDKVIETMYETGKDMNAKYRETSRGGLAMKIVACD
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MEGDEVNTKPTPPENWDRCHAYNERKRRYCRQAPVPSNDVSSAHQPRYCGNHMHLLDKLISSGNTGSQADDTMNKLKRPREYEPSNVTANTNKKDRGKRIPCPIDPSHLIFESALSKHIKVCPAAKQKQDVATNEYYREGVNVGGFGELSVGDGRMSASTTDDVQRANELALAVLRVFRHLFMNTDEVKGEEISTEQLKQLTRDDIYNALPEVDLSSIEESTGTNTTDSNSTANDEPQQAGRLTSAITKYRIKAGGSRHLHQIASILGHLRQKGLIDRENTQPQRTVLEMGAGRGMLGLVVAGAMGASIKSELESKVKLCLVERTGSRAKAETKIRTAIKDAQRKENTTSKPDNSTTDECLRLDLVEVTRIKCDLAHIHLPTAFPFLTANQTQSDPTSNAVVIAKHLCGAGTDLALKSLRDIAPTGSVNGCVMATCCHGLCTWEDYVGRHCLLELFCESVGRLSNFDETDFNILKRWTSASVLEDTSRNNTEVGDTTDEAKEEHHSNVVEEKGSATHIFEVVSRLGLLCGGSGLGRVCQRVIDYGRCDYIKRQLFSSSRGNGSTSNDDTVSLLHYVQSGITPQNALILATKR
The following text describes a protein:
Function:
Probable component of the FTS/Hook/FHIP complex (FHF complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Sequence:
MMSSVSTESKLQQAVSLQGVDPETCMIVFKNHWAQVVKILEKHDPLKNTQAKYGSIPPDEASAVQNYVEHMLFLLIEEQAKDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKIEQLKMYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEEKLVVLLNQLCSILAKDPSILELFFHTSEDQGAANFLIFSLLIPFIHREGSVGQQARDALLFIMSLSAENTMVAHHIVENTYFCPVLATGLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPSLVQFMNSLEFCNAVIQVAHPLIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFILLHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLIPCNHMMLSQRWAVKERDCYSVSAAKLLALTPVCCSSGITLTLGNQERDYILWSKCMHDTSGPVERPFPEAFSESACIVEYGKALDISYLQYLWEAHTNILRCMRDCRVWSALYDGDSPDPEMFLQSLTEEGSVSSACPVFGLPQQLPRKTGPQLAPRKDKSQTELEWDDSYDTGISSGADVGSPGPYDDLEVSGPPAPIDPPKHIQEMKKNALLLFKGSYIEESDFQDDVMVYRLCAEKDSEDMKDSQEEAARPPAEAQAEVQSVPINNGPLLSTQPETDSEEEWNRDNSDPFHSEPKEPKQEREPEAAPESNSELASPAPEAEHSSNLTAAHPESEELIAQYDQIIKELDSGAEGLMEQNYPTPDPLLLTKEEEGKEESKGEKEKEGKKELEDEEDDFDSFIAEMPAVETVPSPFVGRDEAAFASRHPVRTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLFRVDMSDMTPAALTKDPIQEASRTGSGKNLLDGPPRVLQPFLTHRTKVAEAPPNLPLPVRNPMLAAALFPEFLKELAALAQEHSILCYKILGDFEDSCC
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negative regulator of guard cell abscisic acid (ABA) signaling, especially during drought stress.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MKSRRQNVSVARQTILGRDENFEPIPIDLVIEIFSRSPVKSIARCRCVSKLWASILRLPYFTELYLTKSCARPRLLFACQKHRELFFFSTPQPHNPNESSSPLAASFHMKIPFDGRFNIISPIGGLVFVRYEQILKGRKTPEFVSAICNPSTGQSLTLPKPKTRKRIWGTSHFGYDPIEKQFKVLSMNIGDGVYKEHYVLTLGTENLSWRRIECSIPHVHGSKGICINGVLYYRAKADMFSGTLMIVCFDVRFEKFSYIKILKPTTTLISYNGKLASLVWEGPSYICGKRFEMWVLGDPEKHEWLKHTYELRPRWQNVLGEDLLIFAGMTGTNEIVLSPKYPSHPFYVFYYNLERNTIRRVEIQGMGAFKVNEDYIFLDHVEDVKLI
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MNFFDKLDKAIAQQGSLLFVGLDPNPEMLPERYGRTASIAALRDWMRALVEQTAASICAFKPTLGFYQALGPAGIDLLLEVLEWIPPHLPVILDAKHGDLNTGTQLARTFFEDWGVDAVTINPFAGQDAVAPFLLYPRKGVFVLCHTANPAAQAMQAHPGQQPPLYQQVVREARGWGLPEQLGLEVGTVRPEILARVRAAAPERLIMVRSLWAAPPGALASMLAAGLDAAGAGLLVPVPQECLGADTPGLSVAALRCEIEAIRTVPGDVPSSCTLWQPDVCLIETDRLLDLALQLFDTGCILFGEYVQASGAVFPYYIDLRRIISNPQLFQQVLLAYAEILSTLSFDRIAGIPYGSLPTATGLALHLNRPLIFPRKEVKAHGTRRAIEGTFYPGETVVVIDDILITGNSAVEGARKLQSVGLVVRDIVVLIEHGPEASAFLQSQGYNAYAVLPFERIARTLHQAGRIDDSQYAALGEDKLASAS
The following text describes a protein:
Function:
Part of a potassium transport system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLDPILLLGLVVAVLAMSLVAQALSSYFRIPFIIFLLIEGIIAGPEVLNLLNPALYVDGLSTIVAISVSVIVFDGGLHIDLKHIRMVQESVLKLTTIGVFVTFLGTTVLTSLLIEIPLELAALFGALVTATGPTVITPIVRNIQISHKLGKILELEGVLNDAASVILAAMVFEWVAAELSGTDAVVFILYRLGIGIALGSLSGFALRWFFTRGKAISNRTARLVSLTAVFSCFVFSEYLGNESGILAVAIFGIILGTSDFPYKDTIKEFKSDIVIVMLSLIFILLAAMIKFEYILRIGASGVALVLLLIFVIRPFAVFVSMWNSQIGTNEKLFISFVGPRGVVPTAVATYFAIKLDSMGIPGGQTLVGLVFLTVIITVFMSGSLSKKVAEVLEVIPMEILIIGGGKVGRILAERFDKRGENVVVVDISEDNCKKCMELGIRTVQGDAGDVNVLKKAGIENAKYVVATTNQDNTNLLFCQLAKASFGFRGDQLVARVNEIENLQAFWNLGIRSMSPAMTTAVVLDNMIGRPHLFSMCEVGGEGEMMEVKVTNPRVIGKAIKDIQFPEKSLLVMVQRGSDSIIAHGNLVLEYEDIVTVIGEGDAAKQTAAILHK
The following text describes a protein:
Function:
May function as a transcription factor.
Miscellaneous:
MISCELLANEOUS: Present with 2120 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTDIGRTKSRNYKCSFDGCEKVYNRPSLLQQHQNSHTNQKPYHCDEPGCGKKFIRPCHLRVHKWTHSQIKPKACTLCQKRFVTNQQLRRHLNSHERKSKLASRIDRKHEGVNANVKAELNGKEGGFDPKLPSGSPMCGEEFSQGHLPGYDDMQVLQCPYKSCQKVTSFNDDLINHMLQHHIASKLVVPSGDPSLKESLPTSEKSSSTDTTSIPQLSFSTTGTSSSESVDSTTAQTPTDPESYWSDNRCKHSDCQELSPFASVFDLIDHYDHTHAFIPETLVKYSYIHLYKPSVWDLFEY
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MSLITVQLGQCGNQIGFEVFDVLCSDVHSAQGLCSKRENEAYQEIGKERFFTEEKNGVPVARAVLVDMEPKVISQTLSKAAQSGKWRYGSHSHFCQKEGSGNNWAYGYSVHGPKHEESILNLIQKEVEKCDRLGGFFTVMSMAGGTGSGLGAFTTQNIRDAYPNSFIMNHVIWPYGTGEVIVQNYNSVLTLSHLYRSSDALLVHENDAIHKICARLMNIKQISFRDVNQVIAHQLGSVFQPTSSSEGSPQCRRNPLGDLMQSLVPHPEFKMLGLRNIPQMAEKSLAYSSFTWAGLIKHLRQMLISSAKMEEGIDWQVRPPWLGCRATERGPLKKELHFNTSIANLVILRGKDVQSADLGSFKDPALYTSWLQPDAAFCEWRTPRAFNKYEKSATLVSNSQFLLKPLDTIVGRAWNMFASKAYVHQYTKFGMEEEDFLDSFTVLEQVVASYSNL
The following text describes a protein:
Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASLPTGIRLITSFTRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHKHCASHGKVKLNIVNENAFRAPAGKISDNETHCGWAPFDKKNYQQLLGALDYSFLCAYAIGMYLSGIIGERLPIRYYLTFGMFASGAFTALFGLGYFYNIHNFGFYVITQIANGLVQTTGWPSVVTCIGNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGIIIASMGTVCFLFLIEHPRDIKCSSTPLISSKSYENGTNRFRVQKQILYTKDNSKNLDPEIQSLLSDGENGTIQPKFVTVLHGDGGNGMAAISFLGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHFDAKKAGDLSTLFDVGGIIGGILAGVISDRLGKRASTCGLMLLLAAPTLYMFSMVSKMGLEATIVMLLISGALVNGPYALITTAVSADLGTHKSLKGNSKALSTVTAIIDGTGSVGAALGPLLAGLISPSGWNNVFYMLMVADATALLFLLRLIQKELCCTGSMPGEQRQFKEH
The following text describes a protein:
Function:
Regulates the ribonucleotide reductase activity through its mediation of the nuclear localization of suc22, the small subunit of the ribonucleotide reductase. Delays the progression of the G1-S phase transition, thereby ensuring the G1 phase is complete. Interacts with both p34 and the p34-p56 complex, although no direct inhibitory effect on the bound proteins has been demonstrated. The action of p14 may happen coincidentally with the cdc10 function or may happen downstream of this.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MHSSKRVMTTKTHVEQPESSMRPQLPESIQGSLMDVGMRVRKSISTGYKSKQTTFPAYNPPLYNTVSENIALKNTAFSYEPNGTKRPFEQAIPNYNWANPPQDFEEPEWLKPFDVVMEGTNERL
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGKDKHASREELAEYPPETPSHGHSSGKYGTPKKYDPSFHGPIKNRSCTDVICCILFIVAVGGMIGVGVLGWMYGDPMRLIHPTDSFGQVCGIDENVKNASYLFYFDLLECFSSITTTVLNFGCPTPKICMSECPQNTFAPYTLLLQDAQKFIDELELDLNMWDEFICLPGFDPEAEFNDASGPYYQNLAKIFEHRKCATYYLPSTNYADRCVPAFLVAENASLADIFTTGLTNLQTLGGTLIDNDNVTSVFSSAVDKFLNLASVLEVVYEDFVNSWHIILIGLGIGMVLSMIWCFIMRWIAGVMVWGSILCLHAVLAAGIYCCVQQYLDLQGVAGSMDSITFEFTTNLSSYTRLQQTWLIIGIILCVVFLILFLLTICLCSRIRIAVELISESSKAVSSMWSTLFWPIVPFLLQTGVIALWVGIAVYLATSQQAMYQVFDATTSNFTGDSCDIDTFQEESSSDTFTADYNLTSNDTDLSCLFIDYSLPEYFKWLQLYNLFVFFWLINFVIGLSHMTLAGAFASYYWAFNKKDDVPFFALSGAFYRSLRYHLGTIAFGSLIIAIIQIIRVLLEYAEYQLKGKENKVAKFILRCMKCCFYCLEKFMKFINKNAYILVAVYGKNFCSSAKEAFFLLLRNIVRVAVVNKITDFLLFLGQLLIVSLVVVGAFFYFTLEVTWVNAVLPVPAVNYYWVVIIVIGIGVYLISKAFFGVFDMAVDTLFLSFLEDIERHDGSAEKPYYMSKGMMKIVGKKNKKMEEEW
The following text describes a protein:
Function:
Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Secreted, extracellular exosome.
Sequence:
METVVIVAIGVLATIFLASFAALVVVCRQRYCRPRDLLQRYDSKPIVDLISAMETQSEPSELELGDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKNSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI
The following text describes a protein:
Function:
This protein binds to 23S rRNA in the presence of protein L20.
Sequence:
MYAIIETGGKQIKVEAGQEIYVEKLAGEVGDVVTFDKVLFVGGDSAKVGVPFVEGATVTAKVEKQGRAKKLTVYKYKPKKNYHKKQGHRQPYTKLTIDAINA
The following text describes a protein:
Function:
Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Maltose is the preferred substrate. To a lesser extent, also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in glycogen and maltooligosaccharides such as maltoheptaose, to produce maltose which then can be converted to trehalose. TreS plays a key role in the utilization of trehalose for the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P). Might also function as a sensor and/or regulator of trehalose levels within the cell. Thus, when trehalose levels in the cell become dangerously low, TreS can expedite the conversion of glycogen to maltose via its amylase activity and then convert the maltose to trehalose; but this enzyme also can expedite or promote the conversion of trehalose to glycogen when cytoplasmic trehalose levels become too high. Is also able to catalyze the hydrolytic cleavage of alpha-aryl glucosides, as well as alpha-glucosyl fluoride in vitro.
Miscellaneous:
MISCELLANEOUS: Maltose-1-phosphate (M1P), the building block required for alpha-glucan production, is generated by two alternative routes: the TreS-Pep2 branch and the GlgC-GlgM branch, however it seems that the GlgC-GlgM branch provides most of M1P for the GlgE pathway in M.smegmatis.
Sequence:
MEEHTQGSHVEAGIVEHPNAEDFGHARTLPTDTNWFKHAVFYEVLVRAFYDSNADGIGDLRGLTEKLDYIKWLGVDCLWLPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVTLLDAAHRRGIRIITDLVMNHTSDQHEWFQESRHNPDGPYGDFYVWSDTSDRYPDARIIFVDTEESNWTFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMLDVLRFWLDLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRCRKAIDDEYPGRVLLAEANQWPADVVAYFGDPDTGGDECHMAFHFPLMPRIFMAVRRESRFPISEILAQTPPIPDTAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLENDRNQIELFTALLLSLPGSPVLYYGDEIGMGDIIWLGDRDSVRTPMQWTPDRNAGFSKATPGRLYLPPNQDAVYGYHSVNVEAQLDSSSSLLNWTRNMLAVRSRHDAFAVGTFRELGGSNPSVLAYIREVTRQQGDGGAKTDAVLCVNNLSRFPQPIELNLQQWAGYIPVEMTGYVEFPSIGQLPYLLTLPGHGFYWFQLREPDPEPGAQQ
The following text describes a protein:
Function:
Required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Implicated in the formation of stable and biologically active snRNP structures. As part of the U4/U6.U5 tri-snRNP particle, dispensible for spliceosome assembly, but required for conformational changes, which result in U4 snRNA release and the subsequent catalytic activation of the spliceosome.
Miscellaneous:
MISCELLANEOUS: Present with 2380 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MAVNEFQVESNISPKQLNNQSVSLVIPRLTRDKIHNSMYYKVNLSNESLRGNTMVELLKVMIGAFGTIKGQNGHLHMMVLGGIEFKCILMKLIEIRPNFQQLNFLLNVKNENGFDSKYIIALLLVYARLQYYYLNGNNKNDDDENDLIKLFKVQLYKYSQHYFKLKSFPLQVDCFAHSYNEELCIIHIDELVDWLATQDHIWGIPLGKCQWNKIYNSDEESSSSESESNGDSEDDNDTSSES
The following text describes a protein:
Function:
Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm. Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling.
Subcellular Localization:
Nucleus speckle.
Domain:
The basic polyhistidine region acts as a targeting signal to nuclear speckles.
Sequence:
MAASALYACTKCTQRYPFEELSQGQQLCKECRIAHPIVKCTYCRSEFQQESKTNTICKKCAQNVKQFGTPKPCQYCNIIAAFIGTKCQRCTNSEKKYGPPQTCEQCKQQCAFDRKEEGRRKVDGKLLCWLCTLSYKRVLQKTKEQRKSLGSSHSNSSSSSLTEKDQHHPKHHHHHHHHHHRHSSSHHKISNLSPEEEQGLWKQSHKSSATIQNETPKKKPKLESKPSNGDSSSINQSADSGGTDNFVLISQLKEEVMSLKRLLQQRDQTILEKDKKLTELKADFQYQESNLRTKMNSMEKAHKETVEQLQAKNRELLKQVAALSKGKKFDKSGSILTSP
The following text describes a protein:
Function:
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGO-Y14 heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGO-Y14 heterodimer interacts with the EJC key regulator PYM leading to EJC disassembly in the cytoplasm (By similarity). EJC core heterodimers play essential roles in plant growth and development, and pollen and seed development. The MAGO-Y14 heterodimer selectively binds to the UDT1 (UNDEVELOPED TAPETUM 1) pre-mRNA transcript and regulates the splicing of UDT1, a key regulator in stamen development.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Sequence:
MAAAAEDVEFVDYDRDEEEEEDAMDEDDRGGGRGGRALPVPHIVSQGVMRSRGRLLGRSTSVLASNRDRFDSLADAGNPGHGPQRSIEGWILLVSGVKEDAEEDDLYNTFSDFGHVKDLHLNLERRTGYAKGYALVEYESFEEAQTAIKAMNGTQLLTRTVYVDWAFSRGPIQKLTSTRPLHRRSRTPPRRLAALTC
The following text describes a protein:
Function:
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Both up-regulates and down-regulates gene expression during neural development. Acts early in neural plate development to induce proneural gene expression and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros.
Subcellular Localization:
Nucleus.
Sequence:
MSFPQLGYQYIRPLYPSDRQNVGGTRSGTELSPAGTLSNVLSSVYGTPYAAAAAAQAYGAFLPYSAELPIFPQLGSQYEMKDSPGVQHAAFSHPHAAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSDHEEDKHEDDEEIDLENIDTEDIESKEDLDDPDTDIHSDSKTDARSDSEASDGFEDLNAPEDRLLKSVVGQRQVLNEEPQDKCALSSDAKASQPACEQIKLDRIPSSPPLENNIPAAHKPKIWSLAETATTPDNPRRSPNTGGSVNTQNLIAQHRLIASPGSRFQGWTGRAFSAQQLSLLNSAHFLQGLSVSHTALGSGTASFPKAAEPKHSTDSLTDRSSTVDIEKKIPVLNTAFQPVQRRSQNQLDAAMILSALSSS