lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
Sequence:
MLWLSIVLWQIRTVSRALAPHLTHAYAKDVKFGADARALMLEGVDLLADAVAVTMGPKGRTVIIEQSWGSPKITKDGVTVAKAIDLKDKYKNIGARLVQDVANNTNEEAGDGTTTATVLACSIAKEGFEKISKGANPVEIRRGVMLAVDAVISELKNQSKPVTTPEEIAQVATISANGDREIGVITVKDGKTLNDALEIIEGMKFDRGYISPYFINTAKGQKLKKKISSVQSIVPALEIANAHHKALLIIAEDVDGEALSTLVLNRLKVGLLVVAVKAPGFGDNRKNQLKDMAIASGGTVFREEGLTLNLEDIQAHDFGKVGEIIVTKDDAMLLKGRGDRSQIEKCVQEIIEQLEITTSDYEKEKLNEQLAKLSDGVAVIKVSGTRDVEVNEKKDQVTDALNATRAAVEEGIVLGGGCALLQCIPALEAIKELPKKKSPGPDGFTSEFYQTFKEQLIPLLYKLFGIISKEEVLPNSFYDTNMVLISKPVSSKTEEKKPQTKHSSK
The following text describes a protein:
Function:
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome.
Sequence:
MASPTKAFNPPEQDLDTLRYSYNAEYTADISTKMRVPDKIQVAEGDEGYAVPSRDDSRMLHHSMDVPDRIMVAGEGQYKGQHQSPRTLDLDTMLPSQPPPVSLQTPPRTLTLEEHLESLEIEERPRSRPRTASGRKEPLANRGMPNGIAIPESDAAPALPNMDAVTPMAEDEVEELRRQLSRVGRRLRILEDENEQRNQRELILYSVTLAFWLINAWMYIRRD
The following text describes a protein:
Function:
Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.
Sequence:
MDEEYDVIVLGTGLKECILSGLLSVDGLKFMMANGALVRVLIHTNVTKYLNFKAVDGSYVYNKGKVHKVPATDVEALKSPLMGLFEKHRARKFFIYVRDYDDNDPKSKEGLALNKVPAKDVISKKYGLDDNTVDFIGHALALYRDDSYLDQSAIDFIKRVKLYAESLARFAGGSPYIYPLYGLGELPQAFARLSAVYGGTYMLNKPECKVEFEDGKAIGVTSEGETAKCKKVVCDPSYLPDKVKAVGKVARAICIMSHPIPHTNDAHSTQVILPQKQLGRKSDM
The following text describes a protein:
Function:
Negative regulator of transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MEVDGAEPARRRSTRATRGRHSKYEEAVEEPGKVKSDKKDPKTSDKNPKTTKLKTPTKAKTTTRSKARKKSKNDEEGVVRCPCGATEDDPSDGKIMIECEDCLEWQHSQCVLQTNDLEQVPDHYVCNECTEKKTQEKETTEAQEESEDKGKGEEEKDSNDKDEKYDSTYVPNNETAEKEPVARVSKSTHKRVGHIDDITEKVRKSAASALKGIFVSVPTSKYSPGAGVSPEQFCETLALTIEQELYDAYGTVEPEIGSNYRDKFRTLSFNLRDSKNETLRIRVMTGQVTPQTLVAMSSEEMMNPELQKLAEEVRAEAIRDTVLVVDEAPRLRRTHKGEEIVGEYEEYIDNVDQALKMERQRDGDGKEAAESRNQIERAVRDIEGANGEADSKTSNSPKESSNSPIVPKWKRDIDLAQGESDHEHDHDHNSDHEDKVNGILGDVSREAREAETDDWTTISEAPFVWTGTVPMAGLDKTSCAAFSLGSSSVHFNPNVSWGSVFYASKPLTIEGRLDKSKADPYLSKVLGAGTRDVAAFCLLPSDSSESDREAYYKLYEYFHSRSKYGVIHNRSTLVKDAYLIPLAPDDAPPYTLGSLVKPSVELSSLKRSRPLLVALYIVGKLSPKRGAAVSVESHVASSEKHPPKRQSMRDRVKQNAGNAGNASRRASDARKSTPPVTATPVTPAAPTLVAPVNAPVGPAPVVPPYAGFQGGVYGAPVGIQRVPGAPMGVPGVPIAPAGMPGVPVAPLGMHGAPAHHMAQSGTPIAPAAHPRKPTGAPPPDLDALKTLLNDPNLRNAPAAPAQNDLLQNPALLMSIIDQAKKR
The following text describes a protein:
Function:
Required to maintain microtubule bundles in inner ear supporting cells, affording them with mechanical stiffness to transmit sound energy through the cochlea.
Subcellular Localization:
Cytoplasm, cytoskeleton, stress fiber. Membrane; Peripheral membrane protein. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). Colocalizes with detyrosinated alpha-tubulin along the length of microtubule bundles in inner and outer pillar cells (By similarity).
Sequence:
MCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPNKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPIQSKSPTLKDMNPDNYLVVSASYKAKKEIK
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MVSEQRAVCPENDDLVEYMRKWWTEKKAEDKPTFTHNTEKTVLKAFTNICKHKTPITTLKEFKEIKGIGKWFVTEMREFFSSNSGASESQDDDLAKGGKKARGSRRYLPKKNSVAYALLISLHRATANGKEFMHKQELIDTAEASGLSRVPIAPELGRGKQKQFGSSPRDWYSGWSAMSTLIDKGLVYKTSNPAKYMLSDGGREVALECLSRSGMLDTTANVVSREEASDSDNQNVENLEFVAAGSPTSPDLNKKGMNDDISVEFLERFTTLGYTREQVVHALAEVSVCPSPQEISTLWPQVLCQLRENEVYCFHSNPQATVRRNSGDVSTSSRYVEGEQNLTRGINPNGLTSFTSTPDYHGKKASQSVHQASQVVLRVPPLEDLQKFEDAYNVVLILDDREHFIRTKSRMLIEKICDEFKILIEVRRLPVGDAIWIARHKQLFTEYVLDFIAERKNVDDLRGSIRDNRYRDQKLRLQRTGIKKIMYVVEGDPNACEGADSIKTASFTTEIVEGFDVQRTSSLGDTIRRYAFLSLAITDYCKRNSSPGLGCKTAGACPKYNQFIKKCEDADKMSVSDVFATQLMQVPQVTEEVAMAVLECYPTLCSLAYAYAALDADTLAQEELLMKKSEGSVNASASKNIFRFVWAD
The following text describes a protein:
Function:
Serine/threonine protein kinase that specifically phosphorylates chloroplast precursor proteins in the cytosol within the cleavable presequences (transit peptides). May be part of a cytosolic regulatory network involved in chloroplast protein import. Does not phosphorylate mitochondrion precursor proteins. Specific for ATP and does not utilize other NTPs. Plays a role in chloroplast biogenesis and differentiation in cotyledons, possibly through phosphorylation of chloroplast preproteins.
Miscellaneous:
MISCELLANEOUS: Plants silencing STY17 does not show visible phenotype under normal growth conditions, but plants silencing STY17 in the double mutant sty8 and sty46 background show more severe retarded growth compared to the double mutant itself.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAIKEETEESCGSRAVVASITKESPRQHRMKLEVYGEVLQRIQESNYEEANFPGFDDLLWLHFNRLPARYALDVNVERAEDVLTHQRLLKLAEDPATRPVFEVRCVQVSPTLNGNSGDVDPSDPAVNEDAQSSYNSRSLAPPTFGSSPNFEALTQAYKDHAQDDDSAVNAQLPNSRPMHEITFSTIDRPKLLSQLTSMLGELGLNIQEAHAFSTADGFSLDVFVVDGWSQEETEGLKDALKKEIRKFKDQPCSKQKSITFFEHDKSTNELLPACVEIPTDGTDEWEIDMKQLKIEKKVACGSYGELFRGTYCSQEVAIKILKPERVNAEMLREFSQEVYIMRKVRHKNVVQFIGACTRSPNLCIVTEFMTRGSIYDFLHKHKGVFKIQSLLKVALDVSKGMNYLHQNNIIHRDLKTANLLMDEHEVVKVADFGVARVQTESGVMTAETGTYRWMAPEVIEHKPYDHRADVFSYAIVLWELLTGELPYSYLTPLQAAVGVVQKGLRPKIPKETHPKLTELLEKCWQQDPALRPNFAEIIEMLNQLIREVGDDERHKDKHGGYFSGLKKGHR
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MDAVLRGGRTRRSTTQRWSGSAHELKPAQTVVVKQEESDVRRVVHLKERWEDLPLRTGSEQPILISFKDPKSFIIHHPDIMLTMTSIANAMPCPRKPILQSLIRMPGPASKPMLYGNILHGLLQGALQEQNFGIDETRRRLNDELRKESIKLDVWGTGLGLDDVRQEVGGKAGLGFEKFGQKWIGSTPKSGEKPSLLAITGLHDVEEDIWSPKWGLKGKVDASVQASILAPGAKQADETIAPLEIKTGRSVGVIAHRAQTMLYTLLMEDRYGIPVPAGLLYYSQLDSVLRVEAKSNEIRALIITRNELASYLANERTLLDSTSSTAPSSEKATFLPPTIDHAKECKSCYAVDSCMLYRRAIDGVPTHDDDDEIFELYAEKAGELTDADAAFFKKWENLLTIEEQDVLRFKSQLWTMTAGQREKAGRCFSNMVISAYSNDLGKSLAKIHRHSYTFTRAQLDASQSAKSLLSGHIARGDPVNLSIEPDILCLSRGFVTDLKPDSITIGVAYVIDPAALLERTKHRNHAMSSDKVVFRIDKDEMAAGTMKMRANLAALFFSDVSDSVKRLRQLVVQHQAPEYEIARMPRPEEIPNSFNADQTQAMERVMTAKDYSLILGMPGTGKTTTIAEIIKALVARGKTVLLSSYTHSAVDTILMKLLNSEFEMLRLGNIDKVHPDVQHLTLEAHEESSDLLQLDARLMRPPVVAATCLSVDHPLFFKRRFDYCIVDEASQITLPTCLGPLRLADTFVLVGDHFQLPPIVGTAVVLYVLYEDDGLNPSDLAVITPYRQQIKLLTGLFADMPSVEILTADKSQGRDKECILISLVRSNASGYIGELLKDWRRINVSFTRAKRKLVIFGSRRTMAGDPLLKYFLQLMEEQKWIYTLPTGAKGHDDGRSMKLEETKAEGSVKAEENGRENVTMKEEKGKGKAKLGESLIEKKPFLRDILAVSGHLHASE
The following text describes a protein:
Function:
ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Its ATP hydrolysis is required for proper assembly of the spore coat. Forms a basement layer around the outside surface of the forespore and self-assembles irreversibly into higher order structures by binding and hydrolyzing ATP thus creating a durable and stable platform upon which thereafter morphogenesis of the coat can take place. Required for proper localization of spore coat protein CotE and sporulation-specific proteins including SpoVM.
Miscellaneous:
MISCELLANEOUS: Present in an increased level in yabG mutant spores.
Subcellular Localization:
Cytoplasm. Note=Uniformly distributed on the membrane around the forespore, lying close to or on its outer surface. Expression only necessary in the mother cell chamber of the sporangium for the formation of a mature spore. According to PubMed:8299942, not a coat protein of the mature spore, is only transiently associated with the assembling coat. According to PubMed:9922240, present as a component of the fully mature spore. Proper localization requires the expression of a gene spoVM which is under the control of the mother cell transcription factor sigma E.
Domain:
Extreme C-terminal region (AA 487-492) is required for its proper localization into a spherical shell around the developing forespore. N-terminus (AA 1-64) is functionally important although largely dispensable for proper localization.
Sequence:
MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLPNISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYTVPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDIARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVESMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRLRDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRDHLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVRLKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLSSIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MNDDCVISADSEASSVAQKVTSILPSMSIAAIQQHVESLASNGQLTPRLITRKCLPLVRKLYNHEHGWVFKDPVDPVELGIPDYFDIVQHPMDLALVETKLENGVYKDLDSFERDTKLVFENAILFNGEKNDVGGMAKQLLFMFDEDLKAVMKGMGLVHKSEKEEPKKKDDTSCTLCGNHRRLFEPTTLYCSGQCGMQKIRRNASYYTDRYRQNQWCEKCFDVLMEEKPVLLDDGKETKKSLLVKMKNDSTPEEKWVQCDNCHNWAHQICALFNEVQSSNAFTCPKCFLKQQDRATSPELTSFKDAAALPQCKLSTVIEEGLATTLSVEYEKIAKERGCTVAQVEKAEGLCVRVVSSLEKKHKVRDEMLGRYSKKGYPSEFPVTSKCILLFQKIHGVDVLLFGMYVYEYGDKCAAPNRRRVYISYLDSVQYLEPSSYRTTTYQSIIVEYLRYARMRGFHTAHIWSCPPSKGDEYIFYCHPSSQLVPKDDMLCAWYIETLKKAQDQGIVLETRTIYDEYFKNNGINSENGEPFDPMSLPYFEGDYIPGEIEKIIRDFNKDENLREETKLKELKSAPAPTAHKKEGNRKGTRSNPGELVNQDRDKVMIRLDLALAKMKQNFIVAQLLSDDFIKAVEKGHDVSSWIEDIEPHEVKQPKQVGKNPCVLDAPTDMSDKMSADGKDGDATKTPASLVIGNTIDEDPLMEQEFIDTRLQFLNYCQKNNLQFDELRRAKHTTMMLLCNLHNPRAEREQQVKVHLQIIAHASCCNGPPACMSTNCRRMKQLFSHVRGCEITYKRGCKMCVRLFMLLTKHARDCDSAGSCAIPFCDRIRERNRRMLRQQQLMDDRRRNAQNDRHREEEDDAQARV
The following text describes a protein:
Function:
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNKRSQNSPYITPNSSYTTLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVLGLVIGELLYHKFYQYDEGKLSKLRASIVSAHGFTKLAKAIALQDYLRVSSSEEISNGREKPSILSSAFEALMAGVYLEAGLAKVQKIMQNLLNRAYKRLDLEHLFMDYKTALQELTQAQFCVIPTYQLLKEKGPDHHKEFEMALYIQDKMYATAKGKSKKEAEQQCAYQALQKLKEAK
The following text describes a protein:
Function:
Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development.
Subcellular Localization:
Nucleus.
Sequence:
MGISEEIKLEELPQEAKLAHPDAVVLVDRAPGSSAASAGAALTVSMSVSGGAPSGASGASGGTNSPVSDGNSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYLPGGAATMQTVVGAALPPNPFTHLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGMYSPSSSFQSLLANMTAVPRGTPLGKPPALLVGSPDLHSPNHMLASPPTSPASGHASQHQQHPTAHPPPPQAPPQMPVGVQPAQLSPQHLVGIALTQQASSLSPTQTSPVALTLSHSPQRQLPPPSHQAPPPPPRAATPPEDRRTSSIAALRLKAREHELKLELLRQNGHGNDVVS
The following text describes a protein:
Function:
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Sequence:
MSRSSKKGPFVDPKVFFKVQKAAETGSKEPIKTWARSCTIVPEFVNVTFMVHNGRQHIKVLVTEDMVGHKLGEFAPTRTFKGHGGKGKR
The following text describes a protein:
Function:
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MVPWTYGERNPKFREKLNGRPSVLLLNKMDLVEPGKRQEVLKKFESQGIRTVFTDCKAQHHYSAKRIVPAVLDAVKDAEYEGSYIRKDPDKPYHLLVCGLPNTGKSSLINALRRTHLRKGKGTRVGKLPGMTTAIQEKNMINDEPKMYIFDTPGIMAPHIPTAEIGMKLASIGCFKDHMIGEDLIADFILYTLNKRKKLEYVQKLGLENPSDSIDFVLRHMATAQQYLIKGDRPDYLRASIQLISSYRKGEYGCFMLDG
The following text describes a protein:
Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAEEEGPPVELRQRKKPKSSENKESAKEEKISDIPIPERAPKHVLFQRFAKIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINAVQQMSLYPELIASILYQATGSNEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLRENWALPYFACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDKVYEVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQLNVKKGSFVAKIIKVINFYLVCTLTITLNIIMKMFVPHKENGHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSLKETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILSMAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEGDKLTYSKYGRFCHEVKINYSPYVNYFTRVYWNRSYFVYKINTVISFQS
The following text describes a protein:
Function:
The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4-ethylbenzoate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTAPSLVPVTTPSQHGAGVPHLGIDPFALDYFADPYPEQETLREAGPVVYLDKWNVYGVARYAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRTRAVLSKVLSPATMKRLRDGFAAAADAKIDELLARGGNIDAIADLAEAYPLSVFPDAMGLKQEGRENLLPYAGLVFNAFGPPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPSLARNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGPLKRRFNNTLRGLESLPIQLTPA
The following text describes a protein:
Function:
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSETRTLYSQLPAIDRLLHDSAFLSLRDRYGHTQVVDLLRRMLDDARDVIRNTQTLPDWYADWAQEAKLRLENAAQSALRPVINLTGTVLHTNLGRALQAQEAIEAVTQAMRAPVTLEYDLDGAGRGHRDRALATLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHAKDYRQAVNENTGLLMKVHTSNYSIEGFTKTVEEAELAEIGRELDIPVVADLGSGSLVDLSQYGLPKEPMPQQLIAAGVSLVSFSGDKLLGGPQAGIIVGKKAMIAQLQSHPLKRALRADKMTLAALEATLRLYLHPEALAEKLPTLRLLTRSEASIREQAQRLQARLAARYGDEFALEVKPCLSQIGSGSLPVDRLPSAAMTFTPHDGRGSRLEALAARWRMLPVPVIGRIYDGRLWLDMRCLEDESRFMEMMLK
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MSSTKRITMPRRTQEFEISAPQSSVKKSQARVSRIAQPVRKSSKQSGIGQFGENGRSRSVERGLNALAGLPSTAVKKSLNPPRSSSATPQLRTPHRSVFHHGGLNAENIPSFSIPSTVERERCTVEARPIFDYLAQANVPDLPKEFIERGNIKTMSMKQFLIIVAHLLRQIGGHRYKIGTNFIEDIIKAITELQCPFTVSKSMLKTPSAPHSIQQVVTMLTWLVQLAPVPVTDWAPNYQHVAEFPTPEYTQFFFQSATESFHLWNLKREEEFEAQVERMVDRLVAAKTGGLSQEQVRQRTEQIRQQLEAISVDRSSGQMREQSFDEVQREVVEKQRIVKQLTEETKQLDRQFERQQQEYYLRQDQYYDCESAIQRVKEQLARQQMTAKERDELQAEIAYDRNVVAAKRNAIACLDGESSDYQITLSRLIKQKINLISELNTKLYNFSNAIKPDIEFTPIELSLTCSNYPELERTLRALEQQLTAVFAEYQALQQRLSQQKMRLEQQVSDEQLTIEPLETKIAKQTERLQQLQQRRETVVRELVALAERANERGTLEQRTKELDQRIEQAMEQMESNRKAIVKLTYDKQQLMEDGLERCRQALEERHQKLADLREQVDGCEAIMKQIVDVCAKSNEEEPLC
The following text describes a protein:
Function:
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Subcellular Localization:
Nucleus.
Sequence:
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAINQSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGNMGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE
The following text describes a protein:
Function:
Extracellular metalloprotease that contributes to pathogenicity.
Subcellular Localization:
Secreted.
Sequence:
MRLILPSALSVVASCIGNAAGDSYANNQNAVVVDSPQVSANFPDVEGVQLLSPAFLSNATLPSTWANGTSGPTPQSTLGMLDYHLCSLTMMTDLSLQESFVKSIASRNGWINYHDELNSEEGRSIPYVTLSNGKHSDKKLRLWLQGGQHGDEPAGDQGALALLAKFANDAQWASKVLEKIDLLILPRYNADGVEYFQRQLASNYDPNRDHAVLLREQTRAIRQAQSDFDPHIFIDAHEYTGVGPVAQRYIRAQDLLVSANKNPNVNANIRTLNQDFVEDIFVATTAKGLRVGPYFTTSVANGTITIQEPDWHAQANHKGAGNYQALTFLVETRGIRLAAQHFQRRVASQLITLTTIIDKAVSEFESVYATINSGREAFTESNDDLVVLDDYQITSKQIPFFEKDSGKLVNVTVRSQNSDPTRILLTRPRPRAYIFSRAFATVAERLRILGVNVTQLSADYIGTVEALVIETAEVAEAKFEGIAQTSVTTRTSTRQVKIPKGGFWVDTRQKNAGYAFALLEPEGVGSVVRYNIVPGEEGDEYPIFRVI
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MQSRLAEELRALKFDRVWRPSPHRSESDGGSCSYRNSIQRVVTASVAAASTSSTTLVFPSSGSVTSSSSASFTSSAPGSEAHGTPSSGPESYRLLRGEAFRGLSEIASHMVSDRYTERLITEFSRPRLGSGSGGGGGGDEILQTWFSDLGVDWVLRVDEMNLQEKPWSGVEEMIKGWLAALTVMAEALRLTKATLSSGDGDSGGVIPVLPIEKYRPQISAPAWIDDDHAGVTLHDVSPGSGSSNLDQESSDPAPNTSRSRSIAIATVKQAITAYSQAASSRSYRYDQHGAAGPEFQFALFAKASLVKMMCFPDAIAALSRSPEKILRVIDMYAVVSGVSPSLLALLPGATKWLVSERITAVLKTLSGMMRGILHDLESLIREEDSWRTTAQGNDIHPVNQIATCWSRRARTTTATTSCSPSGSYTSSRRRNRR
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MTSARSGGEGQGTSVLGVSWVQREGEPIGDEVDMPTFKEHRNVEWERKGVIRILSIDGGGVRGVIPAVILGKLKEHLGGKEIWECFDAVTGTSTGAILASMLFARKEVEGALQKAALYSPEEASEEYLKLANQIFPSSTSVRGWRKALCGIVPLYSAAPLESKLVTALGEQTLSDTLKPLLVPAYDLRSSSLVFFSSMDKVRGNLPLRDVCRATSAAPTYFPAKSLEGPNLNILAIDGGMAANNPVLHGMAHVFKSPKNFPGPVEKMLVLSLGTGEGGRESKDRSKLASRGRFGWVMHLVDVMMGGTSHAQHLSANKTLTGANYLRLQAVGLSREDMRMDHGDPKHLESLRKKVEQHVCVQEHGKNVYETWEDRLKDFAEKLLEVQ
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEISTQPILAPTNDPSTSSSHGTAATILCCICATPIHPNPSNTCPSCLASTADVTRGISTEATLHQCRGCSRWHHDAGKWIGCELESRELMGLCLGNVSGLKKRKGEGVEGRVRLVDAAWVWTEPHSMRLKIRLTIQREVVTGTILQQSFIVTFIVRNQQCVECQAAFRQGSWKSLVQVRQRVGHKRTFLYLEQLILKHGAHRGCLSIETFKDGMDFYFPDKGKANRFISFLEDVVPMKVKSSKKLIGTDDKSNVSNYKYTNLVEICSLCKDDLLFLPKKLARSIGNINRLVLVKNVSNVINVIDPLTGQTGNIESDAYWRDPFRPVITAARTRLTRYVILGKDPVFLERNMSKLASITAARESDLGANDSQMEEHSHLGYLMKSGDVCMGYDLTEAQLVDDEAEELRTSGKLPDFVFVRKLYGGVATGESDAAKKRMFKLKRLDVKDGEEDKPRKKKKDAEMENVDEEDFMQELEADKEMRTRVNIYKSDVVAKRDDGDSGEEDDEEDEDDQKITLDELLDNLVLDSKPDAADDVMGEEAGEEQQQQLQFTGVEGERAALDNIAYVGRDEAINVNAKDTAVPVAGNVWGKDFLDPDL
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MVGPFKKILHAHNQRFPPSSSSSLDPVVDDSSRKQTRIILSYLLHLSLSLHITYSLCLLHFFFGSSNPFSPMEESNNSAVVDFPDNFMDQLLWEECWEEEATQHDQALSSPSGLKERVACAMGHLQEVMGERELLIQLWVPVETRSGRVLSTEEQPYSINTFSQSQSLALYRDASAGYSFAAEVGSEQLVGLPGRVFLRRMPEWTPDVRFFRKEEYPRIGYARRYQVRATLALPLFQGTSGNCVAVMEMVTTHRNLEYASQLSTICHALEAFDLRTSQTSIVPASLKVTSSSSSSSRTEVASILQGICSSHGLPLAVTWGHQDSSSCLSALISASYAADHGSRCFLAACSEHHLLGGEGIAGRAFATKKQCFATDVAIFSKWSYPLSHYAKMFDLHAALAVPILTRGNRTVQFVLELFFPRDCLDIQTHSLTLASQLKLRFQSSPHLMVDDNQIAEEVRDAATPPLTQEDPKGKQVSFSFSSASSLENRKRKTKAEKDITLDTLRQHFAGSLKDAAKNIGVCPTTLKRICRQNGISRWPSRKIKKVGHSLRKLQVVMDSVEGVQGSLHLASFYSSFPQLQSSSSSSFPFINPTQTVHVPPKSPPSSSGSQSSSGSSTCCSSEEQQLGGFQKPALSHPQLLTLSSMHEDQRPVRVTSSLPPLPSATTPRKAKDGMKVKAMFGDSMLRMSLLPHSRLTDLRREIAKRFGMDDVLRSNFSLKYLDDDQEWVLLTCDADLEECIQVYKSSSLKETIRILVHHPLSRPSFGS
The following text describes a protein:
Function:
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MSHIQIPPGLTELLQGYTVEVLRQQPSDLVDFAVDYFTRLREARSPASIPPAAPPSGSQDLEPGSGLVADANGDSESEDDEDLDATCVAERAWAMKLRLPPTQSGSTFVSRFQFLADLIDEYQVIHPKTDQQRCRLQEACKDILLFKNLDEEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKSYKDGERIITQGEKADSFYIIESGEVSILIKSKTKANKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSLDLIDPGQ