lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine, psychoactive compounds likely to be used in the treatment of opioid dependence. Catalyzes the conversion of dehydrosecodine to tabersonine, a precursor of vindoline; this process starts with the conversion of dihydroprecondylocarpine acetate to dehydrosecodine.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MGSSDETIFDLPPYIKVFKDGRVERLHSSPYVPPSLNDPETGGVSWKDVPISSVVSARIYLPKINNHDEKLPIIVYFHGAGFCLESAFKSFFHTYVKHFVAEAKAIAVSVEFRLAPENHLPAAYEDCWEALQWVASHVGLDISSLKTCIDKDPWIINYADFDRLYLWGDSTGANIVHNTLIRSGKEKLNGGKVKILGAILYYPYFLIRTSSKQSDYMENEYRSYWKLAYPDAPGGNDNPMINPTAENAPDLAGYGCSRLLISMVADEARDITLLYIDALEKSGWKGELDVADFDKQYFELFEMETEVAKNMLRRLASFIK
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
METFKTHITGQFNATVSSITPFAKKTTHYLRTKIGSRVEELSLPEDYVELEQQVDSLKEAYNLVLPIVETVEVDGYDYPTNFRDSITDFGKTVSGKVRNLGNLTPLEQTPLASVGKNLEEKEAAAKPSRTLYNAISRAASEATTKMGAGNPLSSAFGQISVLEEKVGNLQGERDSAISKNFCEQVRAVLYPRFAEAHRVKADVQDKRLQLEMAKLDVESAKPENLEHCKSAVRSAEDELNGAIEHAKILYEQILNKDYNTDLLRSIIKNQLKFHQDAAAALSDITI
The following text describes a protein:
Function:
Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MARVLRRIFSYSKFSRTCTKTLTIKGFGQNYQLTTPFPRSLFTINQEQLSLVNIESKGSVATIKLNRKPVNSFNMQLMEEICLILEDLESNKDCRGLIITSDLPNIFCAGLDLKEVLALRKSKLVTFRKTFQDMWSRLYGSRLVTMAAIKGHAIAGGCVLSLACDYSVMASDFRIGLPELSLGLYFAPWMAGTLSNAVGRNRAEKIIYNAQVFDADDAAGIGLIDKVTHVDAVMTETRKEMNKWLLITGKGRELTKATMRQDLLTLLHNTREEDIEHFITMVRDETTQQLIAARLQKNNTES
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKRIVVTGTDTGVGKTVFSAGLAGLLGANYWKPVQAGLEQEIDSECIRRLGGLSSDRIVPELYRLRTPASPHHSAEIDGVRIDTETLGLPDSGERRLVIEGAGGLMVPLTARTLYIDIFERWQLPVVLCARTGLGTINHSLLSIEALRKRQIRILGIAFIGERNAETESAVCEIGRVRWLGRLPWLVPLTNDRLQAAFKDSFVSSDFLNL
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph1 subunit (By similarity).
Sequence:
MEVETTAKSYDVPASAFSESAVIDTHLDVPSTKTESIERMVEVYEIERSVQVITSSGFNKVALQFPDSLLADSASVARLIEQRASCKAFILADTSYGRHPPLPANKTFLKLYNVRICFKLLAFLHFSSCCVDEIAAEHADAELIIHYGQACLSQTKRLPVLYVFGKNPINVIECSQHFRQLYPDTGIRVLVFYDVVYNHCIGALDEALSPLYPNMTISTIAPEGLPSEPTSQQSSRNPQASDVEGMEVNQCNRRFGRDFTLAANSSISDYQIFYIGEQSLTLRNLMMTYNKCQFSTYDPITNESRRETLNVNKALMKRYHMIQRAKDAQIVGIVVGTLGVADYLKIIERLKKVLAIAGKKSYVFVMGKLNVAKLANFLEIDVFVLVSCPENSLIDSKEFYKPVVTPYEMEIACLRTQEWTGDYVTDFHELLPGKSINTFWTDDNDDSPYISLITGKMQHNYKSSAKEAGETSTSLVQRNQETTLATQQPLTAEFLASRSWQGLQQNLGDTPVTTAVEGRRGIAAGYTDEGE
The following text describes a protein:
Function:
May be involved in the transport of sterols.
Sequence:
MAHLVSATGPTAAGRFSTGGMASGSGGPTTSGGSATGAPNMGKRSDGSAVAAGHSPSDVHNSGGSGHGGSAFPAGGAAAGHNARSSDSGNLVSGSSATGAPGSPTLPAAVNAKGSTSTAGGQAAPHSTGSQRGRLQQLGQRLNFVTGLGRKKHTTFADESAAAAAAGGSAPNTATAGAAPTAPSTLLSATSGGDIRGLSTSTGGAAGPGVPGGASPTVNNVEAFNPPNHPVNPFSYLATPFRVMAKTKAGAAMGRYTAAALRLKRDGMPPASYMWLWLGNFKRWHKRYFVASEAPGVLLIYKRANMKGKVWSTSLVDATVAQDDSHPRQIRLATPSGTIFLRVLRPEERQPWLACLRDSVATYRKHKEVVDTLAAAAGAAGEADGGVGTVAGALPCTVASNAVDQDMEQRRRIRMRVHERLGELAPHVSEVERHMTALGSQLANTAAGFGHLSTPLLPHHSSIGAALSSRGARAPGASAEHGPSPAANNISGSGAGTEPVAPSPTGPSGRQSHSGRGSGGAAGLAAAAVQAADREPSQERLGLIARSRSRSRAAAPGVPAATLTGAMAALMEAVRAALHADALRITTLEAENAALNKTLQIVRTNANRSGARSRGLSTPGVSGITGAAAARATVAAAAAAAGSHADDAMSEGSACTADEDAFDVVEAFDDDDDEGGPFAALGHYPGAGDEEMEGEEDDEDAEEDAAELAQQAEVLNALEVVRQVEYISANHNAEQLKNLLAADTPPPPDAEEDEGKGRHKGGKGKGEETDATLGEDDDDDDDDSDAALMATTGGGPSGAGALIRAGSTAYAMGGRARVYEGRDRLPAPKPLGRGFSIWSILKNMIGRDLTKITMPATINEPTSMTQRMAEVLENRSLLEKAAVETNSLDRLMLVACWLLAGYNSQPQRDNKPFNPLLGETYEWVAPDGTARYLCEQVSHHPPVSCFVGEGAGEQGYSFYGEVETKTKFWGKAIECILAGHMAVKLKAWGEEYRFNLGTITINDVILGRFWIDLSCDMKIRNEQTGETARLFIKPCRGVLKERGKCEGVVYDALGKEVWKISGSTMVALNATLTPAAAEERGASTDPQLVWTRTPEVPNPTEQYCMTRFALGMNDPADPIMPFLPPTDCRFRPDIRALELGEWNRATSEKLRLEEKQRSARKERKEAGIEYHPRWFKQVMFGTKEATQLATQPGAVWAWTGEYWEAREKKAWGELPDIY
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MMEQAQQAHPILSPPLSAVLRAGTLSPGTRYAPSPTVKSLKRILEQQQKKGVLLTPLERNIRSINYQYSLLFKNHHLHHQHQHSPASSRSTTTVQISDSQPPSQQQEQWAINTTTASRIKRWFTLNWSPKSLPESSRNITTTTATADVGADQQNLIAADPDSFSKPKFPLVLCHGLLGFDVLGPAALGLTYFRGVREALEERGVEVYVAKVPACASIEERAKTLAQFIETRLPGQTVNLIGHSMGGLDSRFMITHLRPTSFKVASLTTIGTPHRGSAFADYLLLDILGRQHHSKFLQISKSLGLPGGGKAFVELTSEQMAVFNQNTPDLHGISYFSYAAVCEPSFASPFRLSWGVVYEREGPNDGLVSVASAQWGSYLGTLHNVNHAELVGWVEPWKTSSSKKHLANLHLDDQDQQHQKQKQKQQQQQQQDLSRLMDPDKPHTHEFQVVPFYLQVVDSLAKKGF
The following text describes a protein:
Function:
Heme-containing cytochrome P450 involved in the biosynthesis of xanthophylls. Specific for epsilon- and beta-ring hydroxylation of alpha-carotene. Has only a low activity toward the beta-rings of beta-carotene. The preferred substrate in planta is not alpha-carotene but the epsilon-ring of zeinoxanthin. Possesses a major beta-carotene hydroxylase activity in planta when depleted in its preferred substrate alpha-carotene.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MESSLFSPSSSSYSSLFTAKPTRLLSPKPKFTFSIRSSIEKPKPKLETNSSKSQSWVSPDWLTTLTRTLSSGKNDESGIPIANAKLDDVADLLGGALFLPLYKWMNEYGPIYRLAAGPRNFVIVSDPAIAKHVLRNYPKYAKGLVAEVSEFLFGSGFAIAEGPLWTARRRAVVPSLHRRYLSVIVERVFCKCAERLVEKLQPYAEDGSAVNMEAKFSQMTLDVIGLSLFNYNFDSLTTDSPVIEAVYTALKEAELRSTDLLPYWKIDALCKIVPRQVKAEKAVTLIRETVEDLIAKCKEIVEREGERINDEEYVNDADPSILRFLLASREEVSSVQLRDDLLSMLVAGHETTGSVLTWTLYLLSKNSSALRKAQEEVDRVLEGRNPAFEDIKELKYITRCINESMRLYPHPPVLIRRAQVPDILPGNYKVNTGQDIMISVYNIHRSSEVWEKAEEFLPERFDIDGAIPNETNTDFKFIPFSGGPRKCVGDQFALMEAIVALAVFLQRLNVELVPDQTISMTTGATIHTTNGLYMKVSQR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MVKVQQCVVSNKLPRKRPYICNICFKHFETPSKLARHYLIHTGQKPFECHVCHKTFRQLVHLERHQLTHKLPFKCSICQRHFKNLITFLKHQQLHNETYQNDVKQVKRLVETKQEKPTYGIYRSFSTEEKWVLHPSSKSDHVYGTARRRKKIHACDTCSKMFPSRSKLERHLLIHTGQKPFKCSLCNKSFRQSTHLKIHQLTHTEERPFQCCFCQKGFKIQSKLLKHKQIHTRKKNFQTISFKKKSPESRSVPIKLNLKQDGFENGDTQELEGNTPLDVDSIYIVPFQCPECEQCFESEQILSVHKCLDAGDAKSTKSIKRNHNYKTNVKGKVLSKRRRPGDKQLDAFWSDKKKFKTRFLKNRDLLGEQSSDQNASPKTFKTPHGKFGTYKKVSSSKKKRHLPFSWQKQLQSPSAEINLKGTINSEGILNVDDSMDNDLIYGPSGEEFFDDPEALQRALSAPTDNMHTRHKMCPCDKCEKVFPSISKLQRHYLIHTGQRPFGCNVCGKSFRQSAHLKRHKLTHIEKIPFKRPIYQVEFENLNKLFTHQGDNSQLVGYSEASDTQEYKMTDSSEISEFKVSTESGDFILVTHGRNMQPYLSKKLLETEQRRYSRYHGYSGNSEKNEGLLYQCSVCFKSFRSPSKLERHYLIHAGQKPFECSVCGKTFRQAPHWKRHQLTHFKERP
The following text describes a protein:
Function:
Binds double-stranded RNA and both single-stranded and double-stranded DNA.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Note=In oocytes, expression is limited to the germinal vesicle with highest levels in the nucleolus although a considerable portion is present in other regions of the germinal vesicle. In oocytes that progress to the first meiotic metaphase, diffuse expression is observed throughout the egg cytoplasm.
Sequence:
MSKEFFWGDSLTGTKKEVKWNPSLDDEDDFDNLDSDGIQHFLFLKQAVLGANAKEGERNVVEIETENFDGDNVKQPLFSLKLGLNESSPLDIGIQPPVTFILTAGSGPVFLSGQHMIEISADDEEELEEDDEEEEEEDEVEVNASPDLPVAKSKKRPLSTSDGTAKKTKMAKLDKDADKKEDDDEEEDDEEEDEVMAMMDDDEDDEDDEDFEGGEDDEEEDEEESDEDEDDEDDNEEEEEEDEDEESPEKPLKTTAKGKKGQMNGTTTAKGDNKPKAKAKTDTKLVKGKAKKKVLALDEIKGKLQESSNVPKKEEKFKNYVRSAFHISEAKKLQDLWGWFRASLQK
The following text describes a protein:
Function:
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
Subcellular Localization:
Nucleus.
Sequence:
MDSDKEESSALSQEELDRQEQIAKQFIMPERQAKMAQLFKQVEPVQYCICRTSDTDRFMIGCEKCDEWFHGDCIQVSQEMARTIKQWYCTTCMEKDPMLQIRYHTKKEKHKEKKDKKEKNKDKKKKLKKLLKKHRHSSSGSGLDVALPFDLEKTKKVAVSQVSLSEETLTQQQLANALKRSSRMCGECDACLRTEDCGKCDFCRDMKKFGGPNKIRQKCRLRQCLLKSRKLLRDKLGRPVSMTRYMAQQKARASAAAAAARAAAAAMTTTTDSESDVNFYSNFLQSQSSGNKHDAYADMSGRVFESIGTSDHDYTVFRSPGEKKRAVKLKHAQSREKKPKPAKKALQRHKRKATSDDTSGDKVKFDDSKDPPRQCYGPECVNAARPGSKYCSDDCGLKLATNRIFEFLPQRIQQWQQSPCIAEEGEKRTLEKIRSEQLEARKQLAVLDKQSGELEKTIERAKNVPIDPDQDSQDEGGGDDTELSIYCVSCGHPVHPHRALKHMEKCFAKYESQTSYGSIYKTRIEGANFFCDYYNSQNQTYCKRLRVLCPEHTRDPKVNADDVCGCPLTKNVVDTTGEICRVSKRKCNKHYGWEKLRRAEIDLERVRQWLKLDDLFEQERNIRYAMANRSGLLGLMLHQTFDHDLMNQQNVPFQQNSE
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MASREGDPALGYLTRKETEVKLPRPTRVKNKTPAPIQITAEQILREARERQEAEIRPPKQKITDSTELADYRLRKRKEFEDLIRRVRWNKSVWVKYAKWEESQKDFNRARSVWERALDVDYRDHTMWLKYADVEMKNKFINHARNVWDRAVTLLPRVDQLWYKYIHMEEMLGNVAGARQIFERWMGWEPDQQAWLSYIKFELRYNEIERARSIYERFVQCLPKVTAWIRYAKFEFKNGEITRARNCYERAVEKLADDEEAETLFVAFAEFEEKCKETERARCIYKFALDHIPKGRAEDLYRKFVAFEKQYGDREGIEDAIVGKRRFQYEEEVRKNPLNYDSWFDYIRLEESVGNKGRIREIYERAIANVPPAEEKRYWQRYIYLWINYALYEEIDAQDVGRTRDVYSECLKLIPHKKFSFAKVWLLAAQFEIRQLNLSAARAVLGKAIGIAPKDKIFKKYIEIELQLGNIDRCRKLYEKYLEWSPENCYAWSKYAELERSLSETDRARAIFELAIAQPALDMPELLWKAYIDFEIAEGEFERTRQLYERLLDRTKHLKVWISYAKFEASAIEEEEEDEEQQQQQKHDDEKKKLCIQRARSVFENAINYYRTSAPELKEERAMLLEEWLNMESSFGEVGDVGLVRAKLPKKLKKRRQIEMDDGPTGYEEYIDYLFPEETQASNLKILEQAYKWKKQKIVSDDEEEEEDDDDDMDD
The following text describes a protein:
Function:
Might be involved in the organization and polarity of the actin cytoskeleton.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MDGLCYVIFIIFSLLSCAFSPLSYASPATFSRRHLLQAPVTDPSTFSPPFFPLYSSTSPPPPPSPPQPLPPPAPTFATFPANISALVLPRSPKPQTPSRTLLIPAISAVLAAATLIALAFFFYGRWRGQTSHFKDESKSLASDISQSQQQTLPCPPPRNNNTQNKLSVAPSTSDVLYLGNVVTSSGSGFVKPESPDISPLPPLPARSFLLQHHSEANLDEEEEDDDFYSPLASIAGQESRDRRINPYSNCSCSISSHSDSPAMSPSAAMSPPMNSTAPHWSTNQNTHSPSSPERTVRNNKRYGGQSLRMFSLWNQNLGFPRISSASTSPERGMIRTPDAYARSSMYSSVSTTPDRFFRKVLDSSPPRWNDFSRNVKSLFLSSTSASPARDFCINISESSRSLKSSWEKPELDTTQQRESAAAAVTLPPPQRPPPAMPEPPPLVPPSQSFMVQKSGKKLSFSELPQSCGEGTTDRPKPKLKPLPWDKVRPSSRRTNTWDRLPYNSSNANSKQRSLSCDLPMLNQESKVLDPRKSQNVAVLLTTLKLTTNDVCQALRDGHYDALGVELLESLARVAPSEEEEKKLISYSDDSVIKLAPSERFLKELLNVPFVFKRVDALLSVASFDSKVKHLKRSFSVIQAACEALRNSRMLLRLVGATLEAGMKSGNAHDFKLEALLGLVDIKSSDGRTSILDSVVQKITESEGIKGLQVVRNLSSVLNDAKKSAELDYGVVRMNVSKLYEEVQKISEVLRLCEETGHSEEHQWWKFRESVTRFLETAAEEIKKIEREEGSTLFAVKKITEYFHVDPAKEEAQLLKVFVIVRDFLKILEGVCKKMEVTSSLA
The following text describes a protein:
Function:
Protein O-mannosyltransferase that catalyzes the transfer of a single mannose residue from a polyprenol phospho-mannosyl lipidic donor to the hydroxyl group of selected serine and threonine residues in acceptor proteins.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MHSAVPYDGAVTSTASSTDTLHDQAPHDERPTWQQRLRRFGYPAGPATGDVRDRLVPPYTSPSPRLWAFLGVSKPLTDRMIRWSAWGGPLLVALFAGVLRFWNLGSPKAVIFDETYYAKDAWALIHRGFEVNWDKNANDLILNSGGDVPIPTDAAYVVHPPVGKYIIGLGELLFGFDPFGWRFMTALLGTLSVLLLCRIGRRLFRSTFLGCLAGALMALDGLHFVMSRTALLDSVLMFFVLAAFGCLVVDRDKARSRLAAALPVDEDGRVRPDAHVAETLRLGWRPWRLAAGLMLGLAAATKWNGLYIMAAFCVMAVLWDVGSRRVAGAHRPYRAVLRHDLGWAFLSTVPVALATYLLSWLGWILSPSDGTGGYYRDWATKDGANSSWSWLFPDWWRSLWHYETQVLEFHTHLTSPHTYQSNPWSWIVLGRPVSYFYESPSAGSDGCPVDAGEKCAREVLALGTPLLWWVGCFALLYVLWRWLFRRDWRAGAIACGVAAGYLPWFMYQERTIFLFYAVVFLPFLCLAVAMLLGAIIGRPGCTDTRRVAGATGAGVLVLLIAWNFIYFWPLYTGTAIPMEEWRARMWLDTWV
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKLSALQQSYLNRRSNSFRGSLPLDSSAACCIVSVVIGFRFSRLVFLFLFSAASLGGEISALLVVHSALATASPIAKSVSAACPPANRTAAGSRVVVGRHGIRVRPWPHPNPEEVMRAHRIIERIQREQRMLFGVKKPKMVIAVTPTQVRTFQKLHLSSVMHSLMLVPYDVVWIVVEAGRVTNETASIIAKSGLRTIHVGFNHRMTISWSDRHKLEAMMRLHALRIVRKERLDGIVIFADDSNMHRCSFCWNSCSFRKLEWAGFVLNSKLLWKDLDDKPEWIKDLEVFDGVDDIESPLYLLGDTSVVEPLGSCGRQVLLWWLRVEARTDSKFPAQ
The following text describes a protein:
Function:
Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Senses H(2)O(2), maybe via the redox state of the membrane. Activates HprR by phosphorylation. Can also phosphorylate CusR.
Miscellaneous:
MISCELLANEOUS: HprSR and CusSR form a unique regulation system, where both two-component systems recognize and regulate the same set of genes, but under different environmental conditions. HprSR plays a role in H(2)O(2) response regulation, while CusSR plays a role in Cu(2+) response regulation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKRLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDILIIHGDSINKIVNRTNVSDGMLNNIPASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSYLNIDIASPGTKINEPEKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHYLNKHNVFRITLPQRN
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Subcellular Localization:
Nucleus.
Sequence:
MSVTEDCLIGIVNNSVKPCDQIVQVIECKVTHSGQLKLALNDKVHYYSGILATQKRDLYNSGELKKFSLIKLKKYVVNNGYRQSIVILDTEVVSNDCNSILGRPQSIKVDESSSAASSNQFSGAPPPQNQPNDNLSHAPPPPAYVPPPPPPSYAPPPQPPSYQQPPPPPQYQQPPPPPQYQQPNQNQYHQQSYQQQNQNQHQNQYQYQQQRQLPQQHAIRQSQNRIIIPISALCQYTHPGWMIRVRIVSISDPRTYRNGEGKLMNITMKDDSGTSIRGTFFNENVDRWQPKLKLNNVYKVSGGRVKVANKEYNNTGNDYEISFDDATSIEDDQDDGSISTLSFNFVKLDQLAERPDNTTVDIIGWVTTSDQAVTFTSKKGNTMLKRRLEIADDTNSKIELTFFGYLANKLPEEPNYVLAAGPCRISPFRGKSLTMFDGNLQVEPAIPETNAIRAWWNQTGQFTLGEMKSLSNGDVGMGGNSQTLHLSAIDEQGLGQNEKGDYFMAYVTLAELSSNKKFCYAACPNEDCKNKGLTPNEDGTYFCEKCQQPKTPRWRWMFNTKISDFSGSLYASVIGNDQVGDLIFGKKVNELHDELADVKDEETMKFTMPLFFRNLKVRLNARLDNYGMESRIKVNIVGASEMNYAEAAKFFASEIEKQK
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation.
Miscellaneous:
MISCELLANEOUS: Present with 1920 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSRRNPPGSRNGGGPTNASPFIKRDRMRRNFLRMRMGQNGSNSSSPGVPNGDNSRGSLVKKDDPEYAEEREKMLLQIGVEADAGRSNVKVKDEDPNEYNEFPLRAIPKEDLENMRTHLLKFQSKKKINPVTDFHLPVRLHRKDTRNLQFQLTRAEIVQRQKEISEYKKKAEQERSTPNSGGMNKSGTVSLNNTVKDGSQTPTVDSVTKDNTANGVNSSIPTVTGSSVPPASPTTVSAVESNGLSNGSTSAANGLDGNASTANLANGRPLVTKLEDAGPAEDPTKVGMVKYDGKEVTNEPEFEEGTMDPLADVAPDGGGRAKRGNLRRKTRQLKVLDENAKKLRFEEFYPWVMEDFDGYNTWVGSYEAGNSDSYVLLSVEDDGSFTMIPADKVYKFTARNKYATLTIDEAEKRMDKKSGEVPRWLMKHLDNIGTTTTRYDRTRRKLKAVADQQAMDEDDRDDNSEVELDYDEEFADDEEAPIIDGNEQENKESEQRIKKEMLQANAMGLRDEEAPSENEEDELFGEKKIDEDGERIKKALQKTELAALYSSDENEINPYLSESDIENKENESPVKKEEDSDTLSKSKRSSPKKQQKKATNAHVHKEPTLRVKSIKNCVIILKGDKKILKSFPEGEWNPQTTKAVDSSNNASNTVPSPIKQEEGLNSTVAEREETPAPTITEKDIIEAIGDGKVNIKEFGKFIRRKYPGAENKKLMFAIVKKLCRKVGNDHMELKKE
The following text describes a protein:
Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.
Sequence:
MDPEVSLLLQCPPGGLPEKQVRAELSPAYDRRPLPGGDKAIIAIWESRLQAQPWLFNAPKFRLHSATLAPTGLPGPQLLLRLGLTSYQDFLGTNWASSAAWLRQQGATDWGDKQAYLADPLGVGAALATADDFLVFLRRSGQVAEAPGLVDVPGGHPEPQALCPGDSPLHKDLPGELVVHELFSSVLQEICDEVNVPPLTLSQPLLLGIACNETSAGRASAEFYVQCSLTSEQVRRHYMSGGPEAHESTGIIFVEKQSMQRLQETEMWPELCPSAKGAIFLYNRVQGSST
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVGTQSFLHLARPLAPAAIGVQPTTAPLNVIIQPQAVFSILDHAIRRDTSVTQTPRVIGALLGIRAEDGMECEVRNCFAIPHTETEDQVEVDVEYQKNMLALQLKANPREVLLGWYTTSLELNSFSALIQNFFASPETGTFPHPAVHLTVSTEAGKEIEAKAYISAPVGVNAERAAESCLFIPVPYEIRYGESEKSGLELISGAKDSESRAAPVVSDIEGLERAVDQTLDLLERVSEYVSSVLDEEREPSNALGQFLMNALSLAPKVDAQDIERDFNNHIQDVLVVSYLANTIRTQIDLSQRLATATLTMGGSDVLATSGSGEGGEKSEQRGQRGGKRGGRGGGRGGGQTREPREPREPREPREPVE
The following text describes a protein:
Function:
May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone.
Domain:
The WH2 domain is found in a number of putative actin-binding proteins; The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains; The KLKR motif is essential for G-actin binding and for actin polymerization.
Sequence:
MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPGPWLQAEAVGQSSDDIKGRNSQLSLKTLR
The following text describes a protein:
Function:
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression. Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (By similarity).
Sequence:
MEALLEGIQTRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDMRDRELKALRSQLDMKHKEVGILHQQIEEQEKTKQEMALEYKEELMKLQEELSRLKRSYEKLQKKQLREFRGNTKSLREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERAKDTICANELEIERLNIRVKDLMGTNVTILQEQRQKEEKLRESEKLLEALQEEQKELKASLQAQESFILDAKMQEKLQTKLKAVDTKHSVERSLEDCQVERKYSSSGQGVLDNVLSQLDISHSSEELLQAEVTRLEGSLESVSTTCKQLSQELMEKYEELKRMEGHNNEYRTEIKKLKEQILQADQTYSSALEGMKTEISQLTRELHQRDITIASAKCSSSDMERQLKAEMQKAEEKAVEHKEILSQLESLRLENRRLSETVMKLELGLHECSMPVSPLGLIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALV
The following text describes a protein:
Function:
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MADQLIRATAADGGIRAVGVITTNLTEEARQRHRLSYVATAALGRTMAAGLLLASSMKQEKSRVNIRIRGNGPLGGLLVDAGLDGTVRGYVQNPSVELAPNAQGKLDVGGAVGQDGFLYVVRDVGFGYPYSSTVELVSGEIGEDVTHYLVTSEQTPSALLLGVFVGKDGVTAAGGLLLQVMPKAARDEALVAALESRLGHLTGFTPLLRSGKSLKDIFQELLGDFGLAILPEVQLLRFDCRCSFPRVLGALKILGQDELEDMIEKDNGAEATCDFCGEVYQADRHHLAQLIGEIQREKAEKL
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MFCAISGEPPKVPVVSRKSGLIYEQRLIHKYINENGKDPVTGDTLELDDLIEIKSSPKTAVPRPPQHSSIPSLLTSLQNEYDAIILETFTLKKHYDNLRQELAHALYANDASARVIARLLNERDQAREALASIQGTIGAGPSSSRTAQDVEMSDSAPAENGSAGAAETGGLPKEIVDVIDSTAQRLSSQRKAKSKRKAPEGYASQSTVADFVEVQKLPSMHHARPAGVSCIATSADGNVLVTGGNDKNVQIYDRKEDQVLATLKGHTKRITQVAVSGVSDARIGSEAANDTAALPTYIVSASEDGTVKVWQPTGATGAKSQAYALSSTADAHKSEVIGVDIHPSEALYGSAGRDGTISLRSLPDGTELLHVDPDLGDTYESFAFHPDGQLAATGTSTGAIRIWEVKTGANASTIQTELSGRVSSLHFSENGYYLAAASDQGKQVEVWDLRKLTAVGKLTVEEEGKTGVSAVKFDPSLQFLAVATDGVNIYANKSWNHLVKLEGTEKLTGLAWDARDGSVVVSSLDRTVRAFGLAA
The following text describes a protein:
Function:
Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain; Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MLGLVGRVAVASASGALRGLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHSS