lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron.
Subcellular Localization:
Nucleus.
Sequence:
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDTEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPSGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPVVHPPAPAVHPQAPGVHPTPAVHPQAPGVHPPAPGVHPPAPGIHPQPPGVHPPPPGVHPPAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MASKAILEELNILSSKIFGTQYKSNNSRTGRKFVVQELKGAKLKSYYPATINYRQLRTLLNDKTFPDSDEELRMEIRKGRIRQGKGASKSKKK
The following text describes a protein:
Function:
Important role in determination of the surface properties of the casein micelles.
Subcellular Localization:
Secreted.
Sequence:
MKVFILACLVALALAREKEELTLSNETVESLSSSEESITHINKQKLENFKHEEQQQREDERQNKIHPLFQQQPLVSPYADPIHYAILPQNILPLAQPAVVVPFLQPEIMEVPKVKENIFPRHKVMPFLKSPVTPFLDSQILNVADLENVHFPLPLSLPLLQPLMHQIPQPLPLLQPLMHQIPQPLPQTPMLTPQSVLSIPQPKVLPFPQQVVPYLQRDMPLQAFLPYQESTHQAQPVTQPLAPLVNSALN
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MAYVKERIYESMFIIAPNVPEEERENLVERVKKIIEERVKGKIDKVERMGMRKFAYEIKKFNEGDYTVIYFRCDGQNLQELENFYRVTPEIIRWQTFRRFDLEKKERKAQREKAAAEATESSEGGSED
The following text describes a protein:
Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSDGSDDDTNNDGNYCKNVSYNFLIQRLAEVSNRKCLLLPKKKNRVDYISIMQTAEFYPELVNSSPPLEPGFTSCEVFVVDKKVDKDTLHLDNFSPYHIGATRRTLERQHSYFYRVNESGNFVPAIKTNGTHILRILVSILGSCPALNRKIYRMVKIESQNKNCLPSLIVYTFEPGHEIPKPNAPAILRRQTSDEIQKILNIPGTSFSQAHSEAVLNRFYDDLPIRDEASDQKRARYSIESTSSTNNQLNEINSFVVPKFEGRQESEQLFRDVKVEQFEESAEISINNRALSPHIQPSKTSVVNRPNQQNRKFQNYDMFSAGVISTATVPAPMFHPHITPIADLKDDDGYDPEELTQRNKLASLYRLVDLFRWSQGIYNHITVRVSTDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGSTNFGVNQAGYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIVGDVGYHEYRGILIDEAERALLVRDLGDRNVMILRNHGFVVCGESIEHALSLTYHLIIACETQIRTVPGGNTDNVHFPAQSAIKQVYKVASQGGGGVNRQNGHVNSMQWKKGELEWQAYMRQLDAQGYVTGNVPN
The following text describes a protein:
Function:
Catalyzes the condensation of beta-alanine with tryptamine to form beta-alanyl-tryptamine (BATT). Beta-alanyl-tryptamine is an essential pheromone produced by the male that stimulates female sexual development during pairing.
Domain:
The nonribosomal peptide synthase is composed of three domains. The adenylation (A) domain is responsible for the adenylation and activation of beta-alanine using ATP (Probable). The thiolation (T) or peptidyl carrier protein domain (PCP) contains the prosthetic group 4'-phosphopantetheine; activated beta-alanyl-AMP is transferred to the prosthetic group via thiolation. The condensation (C) domain performs the selection of the amine substrate, tryptamine, and the condensation of this amine with beta-alanine via an amide bond (Probable).
Sequence:
MPQSTAQLKSPLLHTLLENLTQSSICTSTAIWHVPNPVNFVCNHNENSFDNKNNSVTTITTTDVSTNNHKNTNYDYEQQEQWSNEEINSNQESNEIYTMTFLKLNNAANRVAMNLANYLERKWSSITNKINRTQLNQHSLSIDEPIELRNQSDTVIALFMPPGIDRIVVQIACMKLHLAYMPLDRNVPAGRITQILHKLKPILILIDKDYYDFIYDDDHNDNDKMSDLSSSIDNNNKSLLSRKLSSNDFIIGNLNQLKLTFQLFDVKVYEYIKLMKLSKYYSRSDIYTASIPIRVCLFPFESDPIVLVLFTSGSTSSGPKPVKLRTTQLFNRLEWQWDSTSDMDLPNFENATCNSNTSVKRIGLAKTAWGFVDAFTELFSCLLAGIPVVVPGGSACPSEKSITDVQQLINLTKHFKISHITTVPTQMNLWLKQLRLKPKEIVTSHLSSLRTVIVSGDIVHPKMACEFFQLFKNPEMRLINLYGTTEVAGDVTGLVFRGEIDVKKHTKVVPCGLERENNKSGKPVLSVGTVIQGTAIFIVQDDDDHHLHHEKDNENQPDKWSNPSLSIIGSVDRKPNWDKFPFKILPKGHIGHVCILGQQVSDSASRCQRIESLPEDLNCVDTNKCKSDVESCENNSSKEIRVFMPGDLGFIDPQTNHLYICGRTNELIKINGIRFHANDIDNLFIELKKNWKAKNMTNCTREELLVNKVSETVTLTIQTVHGRDLKLVCFYVLHMNENQNTMNIEPKENYDKLEDLPKQDDFIAVFSHYLPPYLSPTFINIDHIPLMRTSGKVDKEYLRQYYYSKHHCEISEITKVLQPGWVNDPVKHMTENNNSTSDQSFGKNSRDFKLSRGRERARKVLAEVLGIRGPNGDVIPGRPKDDEDFYLLGGDSLLTVLTTEQLRQLGFNVNLDVFTKTGKIGSILTSLQNTESDFLKTQEPFTSDSWTVKEISMNKVLKKSHTCNLINRIPLMEDECYLSPTICPQGSYEIFIEQWNDGNFSVTERHEIVDVLVNAFIEKDRLSHALKLDRTDLTEAIEVFLNAHKSNPGIVLTARYYYENPYEHTFVKNKLVGVIISLPAKHVPSLHLTPKLALVQRFFDECSNKDQFQDISMDNLLATQMVAITSQSPYSKSKYLQYMLSNWKKISLKLLTRLERDLLRIAAKQGYSGVITFNTNEVTEEVCSQLGYKVIQTTMLKSFMNKENLLLLPQYERIRCSYMIKELNPSS
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase. Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids. Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response. 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning. Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MQGATTLDAASPGPLALLGLLFAATLLLSALFLLTRRTRRPREPPLIKGWLPYLGMALKFFKDPLTFLKTLQRQHGDTFTVFLVGKYITFVLNPFQYQYVTKNPKQLSFQKFSSRLSAKAFSVKKLLTDDDLNEDVHRAYLLLQGKPLDALLETMIQEVKELFESQLLKITDWNTERIFAFCGSLVFEITFATLYGKILAGNKKQIISELRDDFFKFDDMFPYLVSDIPIQLLRNEESMQKKIIKCLTSEKVAQMQGQSKIVQERQDLLKRYYRHDDPEIGAHHLGFLWASLANTIPAMFWAMYYILRHPEAMEALRDEIDSFLQSTGQKKGPGISVHFTREQLDSLVCLESTILEVLRLCSYSSIIREVQEDMNLSLESKSFSLRKGDFVALFPPLIHNDPEIFDAPKEFRFDRFIEDGKKKSTFFKGGKKLKTYVMPFGLGTSKCPGRYFAVNEMKLLLIMLLTYFDLEIIDRKPIGLNHSRMFLGIQHPDSAVSFRYKAKSWRS
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MHELKRFTIQKKEKNHTHTHTHTHTQTTTHSMSCSICQQESKYRCPACSARTCSLACSKQHKASEKCSGLPDPTKYLNREALFTDTSVNRDYRFLKRLERDIVVRKQDGESMPIFKRARYNQNRKDGKDGSVMERNGVKIHKVAQGMGRQKRNHSRWDPNIKQFCWTVEWVNVDTNETMTVDKVNPVQSLLECFQKRGSEKGGNGDNKGERKVEKNDTEQTEMKDEHSKQKDGDKKDEEKEVVPLTPRSFYMKRIKSKNTSPILLDPSKPLSENLKDKSVVEYPTIYYTNEEIVASDSDSDSDSDSDSDSGSDDSDDSDDSDDDSDDDSDSAPEEESARQPEMPDIVKTLADSAVNDMAGLEDAFEKAQEEGKQ
The following text describes a protein:
Function:
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRGRRRRHTCWVMYGIVYTRPCPSGGAAACVWPYLARRPKLQLSVYTTTRSNIGAESNIDLVLNVEDFDIESKFERTVNVSVPKKTRNNGTLYAYIFLHHAGVLPWHDGKQVHIVSPLTTYMVPKPEEINLLTGESTTQQIEAEKQTSALDEPVSHWRSRLTLNVMVEDFVFDGSSLPADVHRYMKMVQLGKTVHYLPILFIDQLSNRVKDLMVINRSTTELPLTVSYDKISLGKLRFWIHMQDAVYSLQQFGFSEKDADEVKGIFVDTNLYFLALTFFVAAFHLLFDFLAFKNDISFWKKKRSMIGMSTKAVLWRCFSTVVIFLFLLDEQTSLLVLIPAGIGAVIELWKVKKALKMTVKWQGMRPKVQFGASNDSEKKTEEYDTQAMKYLSYLLYPLCIGGAAYSLLNVKYKSWYSWLINSFVNGVYAFGFLFMLPQLFVNYKMKSVAHLPWKAFTYKAFNTFIDDIFAFIITMPTSHRLACFRDDVVFLVYLYQRWLYPVDKSRVNEYGESYEEKPKKKSS
The following text describes a protein:
Function:
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEIIMIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
Subcellular Localization:
Nucleus.
Sequence:
MDIKKPITSTISSASFSFLTAEDIRRISVKQIINPVLLDTTNHPNAGGLYDPALGPMRPNDICSTCHLNSYQCPGHFGHIELPSPVFHPLFMGNMFNLLRGTCFYCHRFRLPLVVLTKVIGRLRLLEYGLVDDAENIEAEEPRSNTKLTDIDNADGESTDEDGDDAKGSKGSKASSSKSRGSSGETPAEFAHRINQQVKELIKAAKASGKAQMEPEAGSLAYTARKKCINEFMKDIHRRQCGQCNAISPTVRRDGFLKIMEKALLPAEVASNEHKGYMRVSPVKRVAAIERRLAASTASTSASTDAVDDAGLASQAISAENAPKGTVYRVMPAVECQAHLRLLFHNEGPLCSLIFGRNGPFRLGNSEGKVKAKVGSSIWSTPNGASADSFFVSVLAVPPTRFRPASIMGDMTFENSQNELLTNVLKTTFSIRDQITELTRLVSKKDFPELGPDASEADYRAAEAQLIKGREDTRRKVLNSMMQLQVDVNSFIDASKNPMPLRQGQLPPPGVKQGLEKKEGLFRKHMMGKRVNFAARSVISPDVNIETNEIGVPPVFARKLTYPEPVTVHNVQLMRQLVINGPFKYPGAVAIRSEDGTETQLDKLSVEERTALANQLLTPQEHSSKQARGTFAGLGSSTRTPIANKQVLRHLRDGDILLLNRQPTLHRPSMMAHKARVLVGEKTIRMHYANCNSYNADFDGDEMNMHFPQSQAARAECYYVANTDNQYLTPTSGNPLRGLIQDHVVAGVWMTSKNTLYTRAEYQQMLYGALRPEGKYTGGGRVLTVPPALLKPEPLWTGKQVISTVLLNLKPAKADGLNLTSKAKVAGRMWGKDHASEEKVIIEDGELLQGVLDKAAFGASSFGLVHAIFEIYGSETAGKLLSILSRLFTKFLQTNAFSCRMDDLLLSKEGDEWRRTTLDAAKNQGKGVAMKTVGLEGEDEKNPDTDRNLRIRLEEVLRDDDKLAVLDGEMMNSSNALTSKIIESCLPAGLYKKFPENNMQMMTGSGAKGSAVNVSQISCLLGQQALEGRRVPLMVSGKSLPSFRPFETSARAGGFVSGRFLTGIRPQEYFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGVHIQYDNTVRNADGSVLQFNYGEDALDTTKSKYIGQFDFTAANFENYNKRYDPKQLGEVVEAELAAEHMKKALKKPHKYDPVLSVYLPSTHFGSMSEKYAKEIEAYIEKNPSKLLADKKKKSKKRKSEASAPDEATAVEKLRFAKEKLGVEAFRAMCKVLYHRGLVDPGEAVGLLAAQGVGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMTASQHIKTPIMRLPVLDGITADQIKTFCKDGSRLVLSQVIDEAIVTEKISPKSEGTGFHRQKTYTVRLNFYPADECKEEYNCTTAHILHGLQETFAPNLENSINNEMRKQKREHALQAAAIGKGRVFSDNAPAGDNADEDGERANGVVGRSQTRSRGNEADSDDEEDASSDAGDGDADDAKRKQKSAAHASYEEGDDEEMGGPSTTEDIEAAFSNGGSKKRSSDVMDVDSDSESDSSEDGSINEEWAEQTCALERALQENSKYINAFRFDDVKARWAEFDLTLNTQSQKLLLINIVERVCRQSVIHEIPNIARVMKPPPKAGEEGVSLTAEGINFRDLWDFGFGVIDLDNLYTNDIGAVLHTYGVEAARAAIVAEMRGIFDTYGIAVSPRHLFLIADYQTAAGGFRPFNRSGISESSSTLLKASFEMTMAFIGGSALHGEVDMLKTPSSKLVVGRPVNSGTGTPEIRLALPAPIGAAA
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAFLNVNFGEVKHDDDTYGDDHDLFFTPLSSPTRLSTKRRPSKNWCNPILQHIKALLPFKMRRNPSSDETKKTKKKINMKTKTKKSSFHPPAYGVRTNSDEYNFSTDDAFDRFMLYLMPFETSGGGRLYVDHNYEEETHEFPRSINPQKKATSDDDDLLNEFMLSWEPFKNRRDPNYFDEEEVEFPRSNIDPPNTPEEVDDIVAHDNKFMASSRVSHEVGKPSDSKNIEYVPAVNNNFGCNICFEPKAGHQWFDIKNCSHGYCTECMVNYVVSNLQENVTTIRCPDPDCASGSIEPEDCDWILPQEVFESDCSAMLIIDNDDGSEVVRQSQCPHCRRLFCAHCKVAWHEEMECWEFQELNDDERGREDIQLRNLANMEDWKRCPNCKFYVEKKTGCNVMKCRCRATFCYRCGQSLSVPKNQRHYCSYCTG
The following text describes a protein:
Function:
May play a role in cis-jasmone-activated defense response to aphids.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSSTKTIMETIYLILSLFFFFIFLSLKLLFGPRPRKLNLPPSPSRPFPIIGHLHLLKLPLHRRFLSLSESLNNAKIFSLSLGSRLVFVVSSHAVAEECFTKNDVVLANRPEFLVGKHIGYNSTTMVGAAYGDSWRNLRRIGTIEIFSSLRLNSFVSIRQDEIRRLIICLAKNSQHGFVKVEMKPLFMCLTINNIIRMVAGKRFYGDGTENDNEAKHVRQLIAEVVVSGGAGNAADYFPILRYVTNYEKHVKKLAGRVDEFLQSLVNEKRVEKVKGNTMIDHLLSLQETQPDYYTDVIIKGIILVMILAGTDTSAGTLEWAMSNLLNHPEVLRKAKTEIDDQIGVDRLVEEQDIVKLPYLQHIVSETLRLYPVAPMLLPHLASEDCIVDGYDVPRGTIILVNAWAIHRDPKLWEEPEKFKPERFEKKGEDKKLMPFGIGRRSCPGSGLAQRLVTLALGSLVQCFEWERVEEKYLDMRESEKGTTMRKATSLQAMCKARPIVHKVLDASCP
The following text describes a protein:
Function:
In tachyzoites, required for the cellular trafficking of guanylate cyclase GC to the cell membrane and for GC guanylate cyclase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=In intracellular tachyzoites, localizes to the apical cap, to the cytoplasm in disperse foci and to the residual body.
Sequence:
MRMQWFLLRHAYFIKGEDFAVAVALLDLALYVLIGTNSLQFLDQSPEKALFGMITSALIFIIALCGFVIVRMFRTSKYKIETYIMPVLIICNIASVFYMQLINKLVGFMTLQLPVLTFLITGYPYVWLVAFVLIGMGGGLIAQSVVCSVSLGSSCPPSVWVDVGLYALQLISGSVAYFTVYELGILIVRYKRHPARYLDAFSDLTALDTIVFSPVFGLGGETARQVQVNQLMAPEKPNLDGLTFLRSASQVSQTTNRIVSRAFYHANTPPHSSSRDALPADKALGAERSDRAGSAVFSPNTLGPLGAPSAGLRDFGPGRPVPGASVVVPKSLKQHAAALHAGANSPHGSPPLQPHGALPGAPRSNTLRGCSGQVSLVPREEESDPACGSLRASVESKATHRSAATLSACESKSRSGRVAGLFRGLSKRPGGPDCEEAAPAEPATSLGSKELGRKKTAGSKAQSSVPILLPRPQSIEETTWRGLASGDLSKDTPVASLASRRNLRMDEQSGDADKASSDVSRDPAKKGAGPFVAEAPVHTAVLPSSSFHSEFPLSRRDSGKELLSDLRESRERTARAASHDTHAAADDSGLQGDPALAAEARVRTALHYHRRWFFSQLFHFRRARRRHRRGAGARDGELVFERGEPDEVESEESCDDSRSRPRETASLSHFSRLSRSRRHKTRTYRRGRSSDGTTAGTSDSDSHGESLEDEGSDSGQESESEESRRRRMRSSRNRRRETSSEDSSSGTSVRSEGRHCREGRANSSVFSSGIRRYFSFFSAATRCAHAASSEEERPVRPARHSWRRGSGDSRECSASTSGVSEACEHSSDASWASSSSLCGSCEKRSIRMSRRRRREGKSRPHASSVSRAERHRGHVSVDLAPLLPSRLFFDTFLNSVRRAERLSKEGRLPASVSRQSSETRGSRTAFLNGDKGCSPTSEAPERSFPASANEVSFRRNEGWERYYDMLLPSLPPFPSARPLYVKPRKNSQAFQNVAVSVSRNETEMTASSPATSFDGPRAVSLSPEGRGARESSDGGGATAPSDLHSRPARAKSLVAAMLHTYPTCPQPPSDLSLFTTPPASPSSLNEVQASRSSSARITSVELGALGKQQGEAAPAGTDAVEEDRDATEDARGSLSSPTGASRRGDRCRRSWSSCEARSSVEMKPNLSIRDARASESPLQSAAPLLSEEKKSRKAQSCAQCRRCGRSRTRLQPSGRLGSSSREDLVGEADSHVSPEKEVFVSSRREKREEQVPRSRREERRDRRGRRWRRGRRRRKARECSETEERRDSSSEWSGTQYSSQERRSHEAVGGVAQLTPICVDDECGKGDAGLSPLLRSEAEESEGEGDMRERQIYETHSDGDVEELSEEEREDRGRSWLRWLFPWGAGEGQGGEKNRRKRSRSEGRREREFISAERRYLEHHRRSRVSSVADSRWGSGSEASADAYPALRRRKGSRVYPVSKPQWFQPSGLTACSSKNSWLAVPPDISLVSAAPALPTPSPSSLSFSGLDQELDCDANSSTAVSSSLPDSTAWQGSGAAASASSPSLRASVDAHFAEAELHAAEHSDGVSVSPRNSPGALSARPMSAAGMPNPDSGIATQTPQTPQTPHTQRPLLLAQSLVAASGKPLPPTRADFEAQRSQGLGDLSQKTPRVFSPQGLGRSQGYGPGGSSYALDSSREAGPSGRLSATPSTRLQGSGGPAFPHSSFPQAIGAAGTPTAPSRDSRTFFGDTGAARASRAGLSGRLASRGTALAPKGTRRLKSGYSVGAADAKDKQKGKVLRYQLVQKFHDRLPWWVARIIVYTDAALENCRRRRRLMQRATWKTKVAMPVRNMLGLFSDEKIETWYVQWLNAFNAKYYPRVAWLLFLICFYATAFHGLLRLRGFIENYPLCIDAVRASPLGEAGFLILVAVRFASQPILSFLLLLPLLRHSGSRLIDFLFCSRAPATPLKSYKLYRWMLALSFLQFVYAVFDNTWHLIAEPGSRHVNPLTIIPASPSLEIAAVQTVYILAVRTPTINLIFLLYIITYIIIFFVALPPGVQQVQLFTISMAGWLFTCVGGQLFYTRAFEVNRRRLFCKYVLPYMLYLEEIAAILYSNPQGEYPLDEGSEDEVSMGSGHLVGDRSA
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKARQIITHLAVLLLLVTPQARAAAPADGDNLATLAYLCPALQLADGDITLHPEQSNLDGSLQDLLALNMSLADAAWAAQFKASPPGATPVAATEQQQKQQAGTPEQIAAWTAAKANVDNTAKFKDVLAKYGYTQENASKLIPLKGPIAQYADAAFGIQQATKTSEKDDKTDSDLKALIKTAIYGHDGGYDATKKEEMGLQGTQNRENHCTAQSNSNPIQTISTMVACLCAVKDDMVSGKAPCGPHADATLKWQADGPPQTPLWPKIRSICPKADGGTVTADRIAAAIAAAKMAFFSKGNDLYVGKFDMAGCDGSNNGACIKYTDQASNSVPSFKQAAWIDKLETVETSLRTRQQNQDIQKQAQTKIETLKQLVKAAAKHAEKLTAPTTQHHSNPKLATTNDKNSQAQKTADCSKLEKAECKPDVGCRYNETTNKCEEDPKSPVVQANKEAKGGATNSEGKNYSGKKTEGECKDSCKWDGKECKDSIFLFRKKFFLIVFAFLVLLF
The following text describes a protein:
Function:
Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions. The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Starting from lanosterol (lanosta-8,24-dien-3beta-ol), it catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of the sterol in the form of formate, and converts the sterol to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, which is critical for ergosterol biosynthesis. Can demethylate substrates not intrinsic to yeast, such as eburicol (24-methylene-24,25-dihydrolanosterol) at a similar rate to lanosterol, and at a lower rate the 24,25-dihydrolanosterol (DHL) to 4,4-dimethyl-8,14-cholestadien-3beta-ol.
Miscellaneous:
MISCELLANEOUS: It is the main target for antifungal compounds of the triazole family like ketoconazole which inhibits by coordinating the iron atom at the sixth ligand position; MISCELLANEOUS: Present with 73200 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKI
The following text describes a protein:
Function:
Functions as a scaffold protein for the assembly of beta-carboxysomes, initiates carboxysome assembly by coalescing RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) (Probable). Produced as a full-length and a shorter form; both forms are required for correct carboxysome assembly and growth (By similarity); A carbonic anhydrase, catalyzes the reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation, supplies CO(2) to ribulose bisphosphate carboxylase (RuBisCO) in the carboxysome. Active when the disulfide bond (194-200) is oxidized, suggesting the interior of the carboxysome is oxidizing; Beta-carboxysome assembly initiates when soluble RuBisCO is condensed into a liquid matrix in a pre-carboxysome by the RbcS-like domains of probably both forms of CcmM (Probable). CcmN interacts with the N-terminus of full length CcmM, and then recruits the shell proteins (CcmK) via CcmN's encapsulation peptide. Shell formation requires both CcmK proteins and CcmO. CcmL caps the otherwise elongated carboxysome. Once fully encapsulated carboxysomes are formed, they migrate within the cell probably via interactions with the cytoskeleton (By similarity).
Subcellular Localization:
Carboxysome. Note=This cyanobacterium makes beta-type carboxysomes.
Domain:
The N-terminus (residues 1-164) forms a trimer with a partially blocked channel forms at the trimer interface. The C-terminus has 4 domains that resemble the small subunit of RuBisCO (rbcS) joined by flexible linkers; the first one (CcmMS1) has been crystallized and folds much like RbcS. CcmMS1 binds to holo-RuBisCO (RbcL(8)-RbcS(8)), a CcmMS1-CcmMS2 constructs binds about 10-fold better, while the entire C-terminus with all 4 CcmMS domains binds with an intermediate affinity. CcmMS1 binds to a different region of RbcL than does RbcS, up to 5 CcmMS1 domains can bind to the intact holo enzyme.
Sequence:
MAVQSYAAPPTPWSRDLAEPEIAPTAYVHSFSNLIGDVRIKDYVHIAPGTSIRADEGTPFHIGSRTNIQDGVVIHGLQQGRVIGDDGQEYSVWIGDNVSITHMALIHGPAYIGDGCFIGFRSTVFNARVGAGCVVMMHVLIQDVEIPPGKYVPSGMVITTQQQADRLPNVEESDIHFAQHVVGINEALLSGYQCAENIACIAPIRNELQRQEDPPTLHVEMLTGEKNTMTTDYGTHVRQLLQQGYQISLEYADARRYRTSSWQSGPTLTGQQESQVMAAIAQLLKEHEGEYVRLIGVDPKAKRRVFEEIIQRPGQAAVASSSSSRPSATVNASPVGSLDAAVVAQVRQLLQQGYQIGTEHADARRYRTSSWTSCAPIQSKQEPEVLAALEACLQEHAGEYVRLIGIDQKQKRRVLEQIIQRPQGPVAIAPKTPTPVATSHASVSSGGNDTLLSADLVNQIQDLLRQGCQVITEYADQRRFRTSSWQSGIKITSAQQINDLRSFLAEHQRDYIRLVGVNPQAKQRVLETIIHRPNGKAASNGNSTRGQGFTPRPTASSQGSPSTHSLSQEVIEQVRQLLQQGYTLGLEHVDARRYRTNSWQSGPRIEAKNLNEALAAIQACLQEYSGEYVRLIGINPAGKQRVAEILLQQAAK
The following text describes a protein:
Function:
May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN.
Subcellular Localization:
Nucleus.
Sequence:
MAACYNAYSAGSQSFEFDEDDDDASFDSGYEKSFETEAQLSSRRRLDFGTPPTPAIPQPYSGGTWDAVPLSSPPAGFVGLLDTSSNHSTRSGRTLVEHLNSRATNGVFDPPLTSTPVKSPEDPNAPRPKRKYAVGKNRVTRSRSPTQVVKIKRFRRMKANDRERNRMHNLNDALEKLRVTLPSLPEETKLTKIEILRFAHNYIFALEQVLESGGSINLDLEKLQNFTLSGERITKELFDALFVNPQPYPLFGRMFPYGQGMAPLAQHQTAPASHAEQPPAMGGFQHGMDYPQQPPGFDFTGSMRFYHQQQQQPHQPHHLQPNPQQESSPQQFSQEKYDLFRGSFDAAANLHSTNLDSGIHQQSSFYSQTPPWKDYPEDQAHVHPVPHQHSYKNFAPQV
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MASLVQEDGSDDVMVVLTCIDRNEQDDFSPNQDEDAMISTVDVYNWNFPSILKHRTIKVKAQRNRQTYDFYNPDLEILVQWNQPTFLSLLASLFGSPVDVTSESFLSLFEGALYFGMETIISKCMMWLTKAISVNGVPLLQLNDLLSIWEFGSELVNNYLPELCTTYIAKNFIWAMSCSSFVDVPYDLLLSSTKHPNLTVDSEMQLCDALLIWISANKGQYTEDCYINLLKQIRISLLPLWFAFGKKTYESLSMCCNESYSGVITLLKQPFTPRMNALQDNELLNLRIRLTELTQRVDISCCTQMNPAILLLSVLPFSLNLEPQLRIKFEKSLINHESINAFPWTKWSNLTFEAVHEIDISNCPMLPLKVAIDIISYSFPSLRKLKAANHLSFKTLDVMQLVKKCPLLCDIDLTVDVSPVIPTQVSILSSFLPAIIPRSFSIHWHSNHSNITKLILEGRNDIEDFDLRAISNICVSISYISLRGCTSVSDVGISSLISKCLKLNSIVACDTSFGQNSILALCSSNASYDHHPSVKHSGRNIPHGCNLQMLHIGGCKGINLSCFSKLMSQAYMLKNLCLRDTEVVDDVLFNFLGSSLEVLDVSNTKVSSAVLAHVIGRNPGLKCLKTRGCNNLLHKETKNLFFEVCKLEEISVGWGFSYFSLQNLKPSLSSLKEIEVGLGASLGQEGLKWLPGISPSLESVVLYFQVISDDIIINMLESLKHLKSFSLCHCLGEISSLGFKVRMPNLRKIRLERVAPWMNNVDLVNLTHNCANLIELSLLGCPLLNSESQKIISSGWPGLISIHLEECGEVTKNGVVSLFDCFALEDILLRHNGSGIQKGFIHEAVTKLPMLRKISLDICDAKDRDKDFDIPEVDNRHFLSHVKIARCKSHTHRCIFDPQHVRASTVSIHRETLVLVWDSKHLTTTLVKERV