lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Large subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The large subunit (synthetase) binds the substrates ammonia (free or transferred from glutamine from the small subunit), hydrogencarbonate and ATP and carries out an ATP-coupled ligase reaction, activating hydrogencarbonate by forming carboxy phosphate which reacts with ammonia to form carbamoyl phosphate.
Domain:
The large subunit is composed of 2 ATP-grasp domains that are involved in binding the 2 ATP molecules needed for carbamoyl phosphate synthesis. The N-terminal ATP-grasp domain (referred to as the carboxyphosphate synthetic component) catalyzes the ATP-dependent phosphorylation of hydrogencarbonate to carboxyphosphate and the subsequent nucleophilic attack by ammonia to form a carbamate intermediate. The C-terminal ATP-grasp domain (referred to as the carbamoyl phosphate synthetic component) then catalyzes the phosphorylation of carbamate with the second ATP to form the end product carbamoyl phosphate. The reactive and unstable enzyme intermediates are sequentially channeled from one active site to the next through the interior of the protein over a distance of at least 96 A.
Sequence:
MPKRTDLKTILIIGAGPIVIGQACEFDYSGAQACKALRDEGYRVVLVNSNPATIMTDPNMADAVYIEPINWQTVEKIIAKEKPDALLPTMGGQTALNCALDLADHGVLEKYNVELIGAKREAIRMAEDRELFRVAMGEIGLDCPRAEVAHTLEEALDIQTRVGYPTIIRPSFTLGGSGGGIAYNREELIDIVGRGLELSPTTEVLVEESVLGWKEFEMEVVRDTADNCIIVCAIENLDPMGVHTGDSITVAPAQTLTDKEYQRLRDASIAVLRKIGVDTGGSNVQFGISPTTGRVVVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELKNEITGGLTPASFEPSIDYVVTKIPRFAFEKFPQADARLTTQMKSVGEVMAMGRTFQESLQKALRGLETGKIGLDPTGLDLGSEDDMAALKRELKAPGPERLFYVGDAFRAGMSVADVYALSFIDPWFLDQIEELISLEQQLADDGMAALDAPRLRLLKRAGFSDARLAELIGTNEEAVRTLRRALKVRPVYKRVDSCAAEFATSTAYLYSTYEDECEALPSNRDKIMILGGGPNRIGQGIEFDYCCVHAALALRDDGFETIMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEIVELEQPKGVIVQYGGQTPLKLARALEANGVPVIGTSPDSIDLAEDRERFQQLVDKLGLKQPPNRIARNADEALVLAREIGYPLVVRPSYVLGGRAMEIVYGESDLARYVRDAVKVSNDSPVLLDRFLDNAVEVDVDIIADKDGNVLIGGVMEHIEEAGVHSGDSSCSLPPYSLSAETQAELRRQVVMLAEGLNVVGLMNTQFAVQVNDAGDDIVYLLEVNPRASRTVPFVSKATGMPLAKIAARCMAGKTLAEQGATKEIVPDYYSVKEAIFPFAKFQGVDPILGPEMRSTGEVMGVGRSFGAAFARAQEAGGIKAPPLGKAFVSVRDPDKQRVLPVAQALVERGFTLVATRGTGAWLQQHGLSCEIVNKVAEGRPHIVDSIKNGEIVYIVNTTEGRAAISDSFSIRREALQHRVTYSTTVAGAKALVHSLEFRGTGPVWSLQELHKELEA
The following text describes a protein:
Function:
Putative oxidoreductase.
Subcellular Localization:
Secreted.
Sequence:
MAVPSVMVLPLLIVVFAGVYYVYNEVMRFMSKSVVRNKVVVITDAVSGMGSECARLFHAGGARLVLCGPSWDKLESLYDSLCSGSDPSQTFTPKLVLLDFSDMENISDVVSEICECYGCVDVLICNSSMKVKAPVQNLSLEMDKTIMDVNYFGPITLAKGVLPLMITRRTGQFVLVNSIQGKLALPFRTCYAASKHAVQAFFDCLRAEVEEFGISVSTISHTFINAGAENATPTEATPITATPTKATPTNPIWAYVCSKLNTHGVSPQILAQEIVRSVNRQSREVFLAHPVPTVALYIRALMPGCFFSVVSAGVRDGAMAEQLK
The following text describes a protein:
Function:
Involved in the system for phosphate transport across the cytoplasmic membrane; Part of the ABC transporter complex PstSACB involved in phosphate import.
Subcellular Localization:
Periplasm. Secreted.
Sequence:
MKKSVIGALAILSSVVALPASAKETISAVGSSSVTPLMEVFSETYMKDHSNVYIEVQGPGSSAGIKAAKNGSADLGMSSRNLKASEKEATLKELVVAHDGIAVVVNPSNTLKGLTSEQVTAIYKGEVKNWKEVGGEDKPIVAITRDTASGTRGAFEDIMSLKKKISGMKVSAISQRAQVANGNGALKTMVASNPYAIGYISLGTVDNSVHALSIDNVVPSVADIKNGTYKVSRPFLVLYREGKPSVETQKFLDWMTDETAQSLVEKNGYISVN
The following text describes a protein:
Function:
Plays a role in the gonadal basement membrane maintenance and/or adhesion early in development. Contributes to the guidance of pharyngeal neurons.
Subcellular Localization:
Nucleus. Cell membrane. Membrane; Single-pass membrane protein. Note=Colocalizes in the nucleus with a punctuate pattern.
Sequence:
MFQHRTTNAQGPPPNRPMPRPPAGMPMMTSSHEHDYTNDYEDPEEMARSRGEGFSNHLLIKTTPPPQPHPNFNSYEMSMSQQRRSQQHQQPMAPPLSDCWGSGVHDSGVLHKNADGAYYIPSGSLRTTSSTLSPASGQRYLDQPHTSGGAPNPTYSDASTTLLKYPLAAGTNQNRRRQQVGTMNNGDPVAGGPMALSKKKKKFDDDSDTCSRWPSKWNILLAAALLVALFVICILLFRAPNYVYTQPAPSSDATSSAAAAASRYQDLGLRALPPAISLGERVDVEFFPKSMATTELTVTKPSRIRFNATVGSGAQLVLLMSAGVHPSLSLHDALFPIRADRIRDSKSPTHIVEEFGSRSRRSLGASSSRHRNIEILSPRSATFEQFVLEGRHYLTFINERSRVEPISFVAEELQRPTTPPKTSSSGTSGAKEHPLASVLVCESNCNQRGECVHGKCHCAPGFTGRTCDEAVCPVVCSGNGVFSGGICVCKSGFKGKECEMRHNWCEVADCNGRGRCDTDGRCRCNPGWTGEACELRACPHASCHDRGVCVNGTCYCMDGWRGNDCSVFADAIVHVPQAQSPPRRGQEPTESSKTRKAQVKPTPTSEKKKESRELQKPIIATVQVPTESSHPCSAHGQLIDDICQCESGWDSVDCSQQACQCVNGDCLDDGSCQCWKGWRGSNCTDKKCAIGCEDRGKCASDGSCKCSSGWNGENCAIDGCPNQCSGKGECGMDRRSSEWSCRCQAGSTGVDCSVSVEMHCDDGLDNDSDGLIDCDDPECCSSSSCSSESVCSTAASPIEVLMRMPPIFNANFAQRVGFLIMEKSVQSYTDSSQFNENLISVIRGRVMWGGSPTGSDDLSTYSNKSTVPLVGVRVSDAAHPLYGFTLTREDGYFDLTVNGARSVTLQFLRTQFQSVKKSVFVSPRQIIHIDDIVLYRQSGGSPPAISMAPARAKCSPTLRRIPDVVLISNWQYTSDGIETDETSDSSRIVVDSRSIFESLPIQGTDVRLVYDSARSPAAPSTMLIGLLYDRVDKELRKVHINIRIAGRRFDRVLAPRTNLTYVFAWDKMNAYRQSESGLVPVTVRVGYEYQGCDRTSERVWQTRRSQMMGATARKMIGTMWTLDIHHHLDIVNNVVEMGNGGYRLITESEPRVSTFAGLDGVKRDVECLKCEGKVDSISLFRPTTVVYAQDGSLIIGDHNMIRRVSQDGQVSTILTLGLADTSHSYYIAVSPVDGTIAISLPLHKQVWRISSLEPQDSRNNYDVLAGDGTVCASAVDSCGDGALAQNAQLIFPKGISFDKMGNLYLADSRRIRVIDTTGHIRSIGETTPDQHPIRTCAQITKLVDLQMEWPTSLTIDPITGSVLVLDTNVVYEIDVVHDVVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPCSCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFNRHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRDSATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNLAVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSNGEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGDDSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRKSEVTWGSWKIRLTYDNSNRLTEHAIDGARVPIKMSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIALGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHYWLERKDPITGRTTEILNDEETTVVTCWSPEGAPMCSRSRNLQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARDASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARASIKIIRDKAGRASESHLEISSSGTQRNQKITRTFDAAGRVASVEQNDQEPVRIIWNSDARVEKINDRVVEWNRGGALKTFQDISYQVDSIGWVVKRDNTTVFGYDGKGRLVSARSSQLRINIFYDREDRVVQIQNSKDFIHFYYGYIDTPKLVSHFSKNGKISTLFYDDDSVPFAMQSDDGTRYALLTDETSTIKAIIGDSNVLRIIDRSVFGALLPSSSSSHPFLPIGYLGGIEISEISVSILNNGRPLDLYSERYMSISPEAVVRLELNEKFSNSIDLMALEIDRQPFRVENVPEDFETWFSLAGLSPNLLPSAHLGLPASSAIVHRLLSSFPRKLRPLTHLTTVLPTRLASDISLTSPTSETSWSIDDVGFSNLLILNEDATTGEVMVEMLSDLKSEEREVISKLFDGVKSLDFATWGLVPTRHLWRAPNSKLELSSTSFSHFTMAVNKDSVELRNGKSKIVVHFSENKAEIVKKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMKPAHQSGLLASVHSWKFRKSE
The following text describes a protein:
Function:
Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2; Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Digests double-stranded RNA (dsRNA) producing 21 to 23 bp dsRNAs, so-called interfering RNAs (siRNA). Required for both post-transcriptional and transcriptional gene silencing. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H3 'Lys-10' methylation necessary for centromere function. Required for recruitment of swi6 and cohesin to an ectopic dg repeat.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The C-terminal dsRNA-binding fold contains a bound zinc ion and is important for normal nuclear retention and function in RNAi-dependent heterochromatin assembly. It binds double-stranded DNA and RNA (in vitro).
Sequence:
MDISSFLLPQLLRKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLIKQKLEEQILIQESNLEHKKISVFLVNKVPLVFQQAEYIRSQLPAKVGMFYGELSIEMSEQLLTNIILKYNVIVITADLFYLFLARGFLSINDLNLIIFDECHHAIGNDAYARIMNDFYHRAKAVLSKKHFTLPRIFGMTASPFTGKKGNLYHRLYQWEQLFDSKAHVVSENELADYFCLPEESYVMYSNKLVVPPSDSIIKKCEETLQGCKLISRAVKTALAETIDMGLWFGEQVWLYLVDFVETKRLKKKALGKQLSDDEELAIDRLKIFVEDWKNNKYSDNGPRIPVFDSTDVTDKVFKLLELLKATYRKSDSVRTVIFVERKATAFTLSLFMKTLNLPNIRAHSFIGHGPSDQGEFSMTFRRQKDTLHKFKTGKYNVLIATAVAEEGIDVPSCNLVIRFNICRTVTQYVQSRGRARAMASKFLIFLNTEELLIHERILHEEKNLKFALSELSNSNIFDSLVCEERERVTDDIVYEVGETGALLTGLYAVSLLYNFCNTLSRDVYTRYYPTFTAQPCLSGWYCFEVELPKACKVPAAQGSPAKSIRKAKQNAAFIMCLDLIRMGLIDKHLKPLDFRRKIADLETLEEDELKDEGYIETYERYVPKSWMKVPEDITRCFVSLLYTDANEGDNHIFHPLVFVQAHSFPKIDSFILNSTVGPRVKIVLETIEDSFKIDSHLLELLKKSTRYLLQFGLSTSLEQQIPTPYWLAPLNLSCTDYRFLENLIDVDTIQNFFKLPEPVQNVTDLQSDTVLLVNPQSIYEQYAFEGFVNSEFMIPAKKKDKAPSALCKKLPLRLNYSLWGNRAKSIPKSQQVRSFYINDLYILPVSRHLKNSALLIPSILYHIENLLVASSFIEHFRLDCKIDTACQALTSAESQLNFDYDRLEFYGDCFLKLGASITVFLKFPDTQEYQLHFNRKKIISNCNLYKVAIDCELPKYALSTPLEIRHWCPYGFQKSTSDKCRYAVLQKLSVKRIADMVEASIGACLLDSGLDSALKICKSLSVGLLDISNWDEWNNYFDLNTYADSLRNVQFPYSSYIEETIGYSFKNKKLLHLAFIHPSMMSQQGIYENYQQLEFLGDAVLDYIIVQYLYKKYPNATSGELTDYKSFYVCNKSLSYIGFVLNLHKYIQHESAAMCDAIFEYQELIEAFRETASENPWFWFEIDSPKFISDTLEAMICAIFLDSGFSLQSLQFVLPLFLNSLGDATHTKAKGDIEHKVYQLLKDQGCEDFGTKCVIEEVKSSHKTLLNTELHLTKYYGFSFFRHGNIVAYGKSRKVANAKYIMKQRLLKLLEDKSNLLLYSCNCKFSKKKPSDEQIKGDGKVKSLT
The following text describes a protein:
Function:
May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDHMSPRLRAFLSEPIGEKDVAWVDGISHELAINLVTKGFNKAYVLLGQFLLMHKREAEFQKWLICCCGATEFEARECSNCLKEWCSCFL
The following text describes a protein:
Function:
May remobilize phosphate, particularly when cells senesce or when phosphate becomes limiting.
Sequence:
MASRLCLLLLVACIAGAFAGDVIELNRSQREFDYFALSLQWPGTYCRGTRHCCSKNACCRGSDAPTQFTIHGLWPDYNDGSWPSCCYRSDFKEKEISTLMDGLEKYWPSLSCGSPSSCNGGKGSFWGHEWEKHGTCSSPVFHDEYNYFLTTLNLYLKHNVTDVLYQAGYVASNSEKYPLGGIVTAIQNAFHITPEVVCKRDAIDEIRICFYKDFKPRDCVGSQDLTSRKSCPKYVSLPEYTPLDGEAMVLKMPTEREAL
The following text describes a protein:
Function:
Sperm protein required for fusion of sperm with the egg membrane during fertilization. May regulate the expression of sperm surface protein DCST2 (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein.
Domain:
The extracellular domain shows strong structural similarity with IZUMO1 but does not interact with the IZUMO1 receptor IZUMO1R/JUNO.
Sequence:
MTSQRSLSSPQTRRPSVMGLISLVGSIVLLFLLIFRASTWACLFCFTTYEERLRVCQLFVGREETKINLCRNELEGAFEDLKDMKINYDERSYLHDEFTQMTVSLQEKAARRREPFWLAFKDAAAKLKRTIEHLKKAPACIPPCGLQEVARLFHCSGCFSKLCDLPLDCPVQDMLVNRGDQALFSCIVAFELPESEITYSWKFVGGVRTKDVTYFRDMPGAHGYLARIRPVQPKHGGTFSCVILHDQRPLARLYFYLNVTGPPPPEDTELQVTFREVMNRTPAEPEMIQPWSPSLGELLTNPQALTLGNLFLLAATAALGSASVTLLVWLFFRWYLSGN
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in transcriptional regulation. Heterodimer of ARP9 and ARP7 functions with HMG box proteins to facilitate proper chromatin architecture. Heterodimer formation is necessary for assembly into RSC complex. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Miscellaneous:
MISCELLANEOUS: Present with 1790 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Sequence:
MAPFRQDSILIIYPRSQTTLVQFGLNEETFTVPELEIPTQIYRTTRQDGSYTYHSTNKDNKAELIKPIQNGEIIDISAFTQFLRLIFVSILSDRANKNQDAFEAELSNIPLLLITHHSWSQSDLEIITQYVFESLEINNLIQLPASLAATYSMISLQNCCIIDVGTHHTDIIPIVDYAQLDHLVSSIPMGGQSINDSLKKLLPQWDDDQIESLKKSPIFEVLSDDAKKLSSFDFGNENEDEDEGTLNVAEIITSGRDTREVLEERERGQKVKNVKNSDLEFNTFWDEKGNEIKVGKQRFQGCNNLIKNISNRVGLTLDNIDDINKAKAVWENIIIVGGTTSISGFKEALLGQLLKDHLIIEPEEEKSKREEEAKSVLPAATKKKSKFMTNSTAFVPTIEYVQCPTVIKLAKYPDYFPEWKKSGYSEIIFLGAQIVSKQIFTHPKDTFYITREKYNMKGPAALWDVQF
The following text describes a protein:
Function:
Common component of the spliceosome and rRNA processing machinery; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKHHTRTVPLIPIASPVAGHRLTKKIKELISTSCESKNLVYGVKDTKKLLQKNEKGLAVFGGNVTPMDVITHLPAMCENKKQPYVFLSTKEEISAAAQRTSAVACVVIREPKDADTKAKYDEIVSEINALNNPEPTEE
The following text describes a protein:
Function:
Involved in transport of phospholipids. Contributes to transmembrane flipping of lipids. Has activity with phosphatidylserine and with a much lower efficiency with phosphatidylethanolamine, but not with phosphatidylcholine.
Miscellaneous:
MISCELLANEOUS: Knockdown mutants are cold sensitive.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Requires the presence of an ALIS protein to exit the endoplasmic reticulum to the cell membrane.
Sequence:
MDPRKSIDKPPHHDPILGVSSRWSVSSKDNKEVTFGDLGSKRIRHGSAGADSEMLSMSQKEIKDEDARLIYINDPDRTNERFEFTGNSIKTAKYSVFTFLPRNLFEQFHRVAYIYFLVIAVLNQLPQLAVFGRGASIMPLAFVLLVSAIKDAYEDFRRHRSDRVENNRLALVFEDHQFREKKWKHIRVGEVIKVQSNQTLPCDMVLLATSDPTGVVYVQTTNLDGESNLKTRYAKQETLLKAADMESFNGFIKCEKPNRNIYGFQANMEIDGRRLSLGPSNIILRGCELKNTAWALGVVVYAGGETKAMLNNSGAPSKRSRLETRMNLEIILLSLFLIVLCTIAAATAAVWLRTHRDDLDTILFYRRKDYSERPGGKNYKYYGWGWEIFFTFFMAVIVYQIMIPISLYISMELVRIGQAYFMTNDDQMYDESSDSSFQCRALNINEDLGQIKYLFSDKTGTLTDNKMEFQCACIEGVDYSDREPADSEHPGYSIEVDGIILKPKMRVRVDPVLLQLTKTGKATEEAKRANEFFLSLAACNTIVPIVSNTSDPNVKLVDYQGESPDEQALVYAAAAYGFLLIERTSGHIVINVRGETQRFNVLGLHEFDSDRKRMSVILGCPDMSVKLFVKGADSSMFGVMDESYGGVIHETKIQLHAYSSDGLRTLVVGMRELNDSEFEQWHSSFEAASTALIGRAGLLRKVAGNIETNLRIVGATAIEDKLQRGVPEAIESLRIAGIKVWVLTGDKQETAISIGFSSRLLTRNMRQIVINSNSLDSCRRSLEEANASIASNDESDNVALIIDGTSLIYVLDNDLEDVLFQVACKCSAILCCRVAPFQKAGIVALVKNRTSDMTLAIGDGANDVSMIQMADVGVGISGQEGRQAVMASDFAMGQFRFLVPLLLVHGHWNYQRMGYMILYNFYRNAVFVLILFWYVLFTCYTLTTAITEWSSVLYSVIYTAIPTIIIGILDKDLGRQTLLDHPQLYGVGQRAEGYSTTLFWYTMIDTIWQSAAIFFIPMFAYWGSTIDTSSLGDLWTIAAVVVVNLHLAMDVIRWNWITHAAIWGSIVAACICVIVIDVIPTLPGYWAIFQVGKTWMFWFCLLAIVVTSLLPRFAIKFLVEYYRPSDVRIAREAEKLGTFRESQPVGVEMNLIQDPPRR
The following text describes a protein:
Function:
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein.
Subcellular Localization:
Mitochondrion.
Sequence:
MASVGSRLTRFYISRPGVIARRFLAHAGMDDMGVSLSRSSLERLEFDNVALKKLPLDPSTEPGVRQVRGSCFSRVQPTPLKNPEFVAVSAPALALLGLDAEEVLKDPLGPEYLSGSKVMPGSEPAAHCYCGHQFGQFAGQLGDGAACYLGEVKAPAGQSPELLRENPTGRWEIQVKGAGLTPYSRQADGRKVLRSSIREFLCSEAVFALGVPTTRAGSVVTSDSRVMRDIFYDGNPRMERCSVVLRIAPSFIRFGSFEIFKRADEFTGRQGPSYGHDELRTQMLEYVIENFYPEIHRNYPDLTERNTAFFKEVTVRTARLVAQWQCVGFCHGVLNTDNMSILGLTLDYGPFGFMDRFDPDFICNASDNSGRYSYQAQPAICRWNLARLAEALEPDLPPDRAEQVLDEYLPLYNDFYLSNMRKKLGLLRKEEPEDEMLITELMQTMHNTGADFTNTFRSLSQISCPTQEEAEDESETIKQATELLLHQSASLEELKAANRPSMDPRELAMLVSMAQSNPALFQMISDRGTVSRQLERLSRLKELMDTTEEQLRVKHTEHWSDWIQKYRQRLARECESGVDVKDVQTERVRVMNNNNPHVVLRNYIAQNAIAAAENGDFSEVQRVLKVLEKPFSVQEGLEQPGWMGRGGAAIPGERDETEEEGSNSSGAGARGLVPYDSKPPVWANEICVTUSS
The following text describes a protein:
Function:
Strongly inhibits glucose induced insulin release from the pancreas.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle. Secreted.
Sequence:
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
The following text describes a protein:
Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MATFVSFKTYLDTPFWREVNKRKLHEWKLDETPKPIFSQLSLCKSISYDGKKILTNSGERNSDHCRLSLSHDSFKPSNGNPNEVSISGNLILYNTRESFKAAATTKSLEELMKTEATKIWDVITTKTWLQTPHLLSSFTIIAFADLKKFHYIYKTFIPSLKYPKNPEQEAWLRFLIVNVIFLFQIPSLSTDESSLLTYYKRTLAPVFLFSKSSQEPLEIAHLESQVNPDDVLIVVADPSPNPSSAGRLVKNVVAAVAYLHSSWDHCNVISLRSSGSIEIKYSWPANADAVAQNVVPQCSGWEQHYSADLSKQFDPKIMMEEAVNLNLSLIKWRLNPDLKLERYSTLKVLILGAGTIGCNLARGIMAWGVRHISFVDNSFVSYSNPVRQSLSKFEDARKRRGKAETAVDALKEIFPSVQAFGYQLTVPMPGHTIDEKDEEQLEKDVRQLEDLIKNHDVVFLALDSREARWLPTVMASIHRKIAISVAIGFDTYVIIRHGIGLRKDSLSEDVNSEAVPYSQLSCYFCSDVTAPGNSTSDRTLDQQCTVSRSGLSMIASGFAVELLASILQHPDPLAAPASLDDNITLLGAVPHQIRGFLHRFQQIHPSVKRFEKCVACGDLIADRFQKNGWKFVRDVMNSPKHLEEVTGLDELQESVEAIDIDFDDDESVVSV
The following text describes a protein:
Function:
Component of the TREX complex, which operates in coupling transcription elongation to mRNA export.
Subcellular Localization:
Nucleus.
Sequence:
MSTIGAVDILNQKTITSEVAASVTSKYLQSTFSKGNTSHIEDKRFIHVSSRSHSRFTSTPITPNEILSLKFHVSGSSMAYSRMDGSLTVWFIKDASFDKSVEVYIPDCCGSDKLATDLSWNPTSLNQIAVVSNSSEISLLLINEKSLTASKLRTLSLGSKTKVNTCLYDPLGNWLLAATKSEKIYLFDVKKDHSSVCSLNISDISQEDNDVVYSLAWSNGGSHIFIGFKSGYLAILKAKHGILEVCTKIKAHTGPITEIKMDPWGRNFITGSIDGNCYVWNMKSLCCELIINDLNSAVTTLDVCHLGKILGICTEDEMVYFYDLNSGNLLHSKSLANYKTDPVLKFYPDKSWYIMSGKNDTLSNHFVKNEKNLITYWKDMFDNTMIEKRRKNNGGGNNHNKRTSKNTDRIGKDRPSRFNSKK
The following text describes a protein:
Function:
Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAEDRIKSKLRRPASIESTMSSRTKPRHKPSPMSILMPHLMVGESFRKYRPHGLRNIRMNGHLDWNQLRKSFEKQSTFHGISHAATADGKWRWFWYTAFTICLLALLIQIFFLISKYRQYGKTVDLDLKFENAPFPSITICNLNPYKKSAIQSNPNTKAMMEAYSRRIGSGDKTEGIAAALSATGGLHAKVRRAKRKAKGKPRLRDRRYHQAFAQCLCDIEQLTGDRKGSCFAAFKGKIEIDTNNTAGFMNLHTSRCLCQLDTVSKALWPCFPYSSWKEKLCSECVDNTGHCPMRFYKGNELYENIKEQVDLCLCHKEYNHCVSTRDDGIILEISPNDELNDLDIGKKIASQLSAQQEKQAEVTTTEAPTVTQALGFEELTDDIAITSQAQENLMFAVGEMSEKAKESMSYELDELVLKCSFNQKDCQMDRDFTLHYDNTFGNCYTFNYNRTAEVASHRAGANYGLRVLLYANVSEYLPTTEAVGFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPMYPVAEMFGNNTKPCQAVNMDQRECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGSAKVMECLPGDFLCLEKYRKNAAMVQIFYEELNYETMQESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLIVFATQAYVRKRKGSISAQSHHSVPVHRASRVSLNTLHKSSTTQSVKLSVMDIRSIKSIHSNHSSKSKQSILIEDLPPAIQEQSDDEEETTESSRTNGSCRYLAPGEDLPCLCKYHPDGSIRIMKALCPVHGYMVRRNYDYSVSNSEEEDAEDEVHREPEPFYSAPYEHRKK
The following text describes a protein:
Function:
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions (By similarity). Involved in regulation of lifespan extension downstream of the sirtuin sir-2.1, probably through its role in nicotinic acid metabolism.
Sequence:
MTGTTENDNTGEDEKPKDEECAAIEHKDKFNPTAYLNSFYKTASEDTAMQIVLFFLPGILYRLPQKVRSVLDLGAGPTVYLPISLRDRAENIYTSDYAPANRDTLINWIEDKSDFDWDNVCSWIANIEASMETGKQMQNKTRKLMRAVLDVNVHESPVVQSIVWKENEQVQVPDKFQVVSTVFCLEYSCETLEAYFRAVRSACSLIDEGGILIQGGVLDATTYNFGGKTFRCHRLKQAHIIESLKANGMATTAEQGYKFITHDDIFLLVSKKL
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MLHFVIVALMVLPHTCGQNPAIQVLLTNKGLQYGKHVGAEWIQDMLDHVTLPDIQGTFSTLFGTVSYTLSGITITKCDFPEPNVAYSQEYSGFKTSITGLSIALSGNWATKFGILHESGSFDMAIFGVDVTSVVKLERKADGHLSVSSIICDGEVQDVDIRLYGGFSWIFQPFVHYIKGHIIEEIRKNICPAVQTSIEELETHLQAMNVSFDVNQVLSLELPLTGSPVVSPSNLTLGLKGEFYSIQTHAEPPFKSKPFMMPNIPGYMLSAGVSEFTLNSAAYGYFTAGKLQILITEKMVPKFSPIHLNTSSMGPYIPQLPKLFPGLPMTLQVYATEAPTVSLQSDVVNLTIQAAVKASAVESNGSSIPLFGLNVVVMLSGKMWIADGKVKGSVMLNNFTLTLASTQVGPFKTNSLENMCKKGIELFGVPQVNKKLAEGVMLPRMKHIQPVNSILTVEKGFISISSDAQVLDML
The following text describes a protein:
Function:
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Early endosome membrane. Late endosome membrane. Membrane; Multi-pass membrane protein. Recycling endosome membrane. Synapse, synaptosome.
Sequence:
MGKEPDAKKDAAGCDCRRFLQSNWLLISTIVAVVLGIGLGVTVREYGKLSNLDKFYFAFPGEVLMRMLKLIILPLIISSMITGVAALDSGVSGKIGLRAVVYYFVTTILAVILGIVLVVTIKPGVSQNAEDIDRMGSTPDVSTVDAMLDLVRNMFPENLVQACFQQYKTKREEVTSKKRDKNGTLPTVDPLPPIMPTQTSQNKTKVYQIVGMYSDGINVLGLIVFCLVFGIVIGKMGEKGQVLVDFFNALNDATMYIVQMIMWYMPVGILFLIAGKIIEVADWEIFRKLGLYMATVLSGLAIHSVIVLPLIYLIIVRKNPYKFAMGMAEALLTALMISSSSATLPVTFRCAEENNHVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLVLDIGQIVTVSVTATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSQDELGQMEVIPEVNIANPFALETTTPDSEETKTKKSYVNGAFAIDKSDTISFTQTSQF