lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane. Does not use free phosphorylcholine or CDP-choline as donors. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Required for normal bone matrix mineralization.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Primarily localized at the plasma membrane with a small fraction at the Golgi apparatus.
Sequence:
MDIIETAKLEEHLENQPSDPTNTYTRPTEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDYIDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFIKEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNLKVSLQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST
The following text describes a protein:
Function:
Regulates the brassinosteroid (BR) signaling pathway that mediates cell elongation and organ morphogenesis; (Microbial infection) Facilitates the development of the powdery mildew fungus E.cruciferarum; (Microbial infection) May prevent cell death upon A.alternata f.sp. lycopersici (AAL) toxin treatment.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MWNQKHDLESAQTPLYPMMSESPELRWSFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTTTTAGFALYILLILTPLIVMCPLYYYHQKHPVNYLLLGIFTVALAFAVGLTCAFTSGKVILESVILTAVVVISLTLYTFWAAKRGHDFNFLGPFLFGAVIVLMVFSFIQILFPLGKISVMIYGCLASIIFCGYIVYDTDNLIKRHSYDEYIWAAVSLYLDVINLFLSLLTLLRAVDS
The following text describes a protein:
Function:
Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MGENDPPAAEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELTARCDGVSDCKDGEDEYRCVRVSGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIVTAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLKGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
Sequence:
MPLFRTIKNRIKSLRRKQKKMNEGDLEEEMDQQETEEVKEEQVEYSLEEKFRACVDIIQNLPKSGPVKSTYPEMLSMYSLFKQATEGPCNIVQPAFWNVVDRYKWDAWNRLGELSKEEAMEKYVKGALEKIDYCAEQWDWDEMLSTHAKDYDKIEPVLKRNFRIIERDYLESVDKKGAADASSTTTCPTGASSANPEERRSTEQLTVEIPNDAPLVGDLTTPADPLSDAEYCDARDHDSLSRSSSLGSLNDTHHRHSPPGRVRSLKAYCARMDVELRAINAALNALSAATDARHQSIIKLIKNSAVYIAVPSRLSWKSLFFFLVWPFIVHWAIKYFGGQAMIEKLY
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MTPSLVFLIVVIVVVEGQGWRPWDRFNHPGNFGNWGGNNWGTRQRNQEPHDIPPPVPPPGFRGNNDRFGGNIIKVVEIIDLGKSKNRGDILSDFKDVHKKHRHLGRKEWKGKVKQFCHRFPGHPNCRRGKVPDQKELEEMIGQFSKGGIGRFLKRVPKIYIEDPLARVDPKLKGFLENAGRGFGHVSSEHVNKLRDICKRRKCREQPESAKKTRELFTQKLADFETKIAGKDKTDSVQLRFDRTLQIKEALLEKGNLTADIVPVDNGVYDLDTMLTEEQANILLNELNKAGVGDDEIPLPDADTDDEDDDDSTNSASGAAPGSSRLKKSALYFEGNLIKKWDPSSPIRYVLDSSLEDLDKNDVRAAIYEIEKNTCIRFKELSSPPTGSHIVYYKVDSPTFCGLSYVGRADPANPVYLSFGCDNNKGVAIHETMHALGVAHQHLRNDRDQFITINWSNIDPQQYDAFVVVDSKLYTSYGVKYAYDSIMHYNGYTAAQNIAIPTMNPKTNSAVNLKVLGQRQKMGTTDIELLKKMYCQPGCDDKNVYCGAWALKDLCKNPGHDQYMAANCKKSCGLCAIGK
The following text describes a protein:
Function:
May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.
Sequence:
MVDYYEVLGVPRQASAEAIRKAYRKLALKWHPDKNPEHKEEAERRFKQVAQAYEVLSDVRKREVYDRCGEVGEVGGGGAAGSPFHDAFQYVFSFRDPAEVFREFFGGHDPFSFDFFGGDPLENFFGDRRSTRGSRSRGAVPFSTSFTEFPGFGGGFASLDTGFTSFGSPGNSGLSSFSMSCGGGAAGNYKSVSTSTEIINGKKITTKRIVENGQERVEVEEDGELKSLIINGREQLLRINTQ
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit tbp, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of tbp and TBP-associated factors (TAFs). Mediates both basal and activator-dependent transcription.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MFPTIRSCARGTSTPADNYMLARRRTLQVVVSSLLTEAGFDSAEKAAVESLTEMLQSYLSEIGRSAKSYCEHTARTQPTLPDIVVTLIEMGFNVDSLPAYAKRSQRMVITAPPVTNNPVVPKALSAGDNKPHPAHIPSHFPEFPDPHTYIKTPTYREPVCDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDTSTFPLIAARPLSIPYLNALLPSELELQQVDETDSSEQDDQTDTENLSLHLQGDEVGMEKENASVLQQNSMKGGEETLIDNPYLRPVKKPKLRRKK
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity).
Sequence:
MADPRRRFRNKKRDEACSGLLAPVTIARREDAARMMQPKILLKKDRDREQETWDRERDKDRKLERDREAEPSPSCYPDTPPALKTMIVNRTGEVRPADRCQMPLAGGALVQGSGQLSAVPSSSVCAALVSSVPTSRDKGSCSGGAGTAGTSAGAPNALQELQPPRMNRPTPLIVANGIFNANARKLFHKTNTDFTVIGVLGGQSSGKSTLLNLLAAERSLDYDYYQHLFSPEADECIFATRHKLKPNNGQKSILRPRTETLQFFITRERHILLDTPPLMPVGKDSDHQDLYSLGTMAQLLSVCHILILVIDGLALEQLRLINAALRLRPTLHCKGYVRDHMPQVVFVRARAHRIDFEIQQRERLDKKLAYLYGPTGLPIYRGRGDARCLNTFLLPEVSSNKATAFHSCLGELVRQFRERILGCTRISMCHTSTELSEAIWFEILAESARKAAPHFEKIYAEIKLRHLDTRCQWRSDNWRTFSSNAES
The following text describes a protein:
Function:
May play a role in cellular stress response.
Subcellular Localization:
Cytoplasm.
Sequence:
QAFMPRSYQDLMKESLTEVALQKKHYQNLVNSALNSPSLSPINHPRYRDTQTPSMERVSTSVSPASSIRPIPGCPEPGRLPYRHDPLKNYLQYEQAWRNRPSPGEKSHDKFRWQNAVEFISNFSLYLRATKRLGAAWGRPGPAGPDCFNWGTNLDSLPYPMSSSPLIDPANSWHDAHATAPFVVSGAWPDREWTNDDLIKNLPGSFPVRMGSRELEIGKPKYDNACEKAEMTVAEFLQWSSDGVSGLPSINTHWGYMDYLHLVEHDQLDSFCSAFPWSSLLDGDFDDVQPTVWLGTAGAHSPLHYDTMGWNLHAQLRGSKQWILVPPGGPSEEDRLDRHKTLGATRTPYENTTVYSQLDALGDPSLLSSIDGIRVFTLLPGDILFVPPLWWHADPEATDAMEEAMRECIRWLKGEKYDENHPIVQSLIELVNRGRTRYDDFLCRYKHLTPAPTSTVSELTKIDRSKMCLSFVPLRSTPIQKDHIRPWDITKWIESEY
The following text describes a protein:
Function:
Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MMSQQDLPTLFYSGKSNSAVPIISESELQTITAEPWLEISKKGLQLEGLNFDRQGQLFLLDVFEGNIFKINPETKEIKRPFVSHKANPAAIKIHKDGRLFVCYLGDFKSTGGIFAATENGDNLQDIIEDLSTAYCIDDMVFDSKGGFYFTDFRGYSTNPLGGVYYVSPDFRTVTPIIQNISVANGIALSTDEKVLWVTETTANRLHRIALEDDGVTIQPFGATIPYYFTGHEGPDSCCIDSDDNLYVAMYGQGRVLVFNKRGYPIGQILIPGRDEGHMLRSTHPQFIPGTNQLIICSNDIEMGGGSMLYTVNGFAKGHQSFQFQ
The following text describes a protein:
Function:
During infection, may play a role in establishing and maintaining biotrophy; the formation of a tight interaction zone between the host and the pathogen.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRGILVALTAALIFCSLTPAQPVLHIQETNRAKNRANRKLVARQPEYKAVETLEKNVNIAIAVGTALVTLVSAGVGGMLLSDHLACKSVAKQEEIMQKSWDSMHPDGFTPAGDQMRPVSFDCSTQERGLKPLQSYTNGAEMY
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MRRLLPLRPAAVAFAGSARHSSLTMQDKQPKLPNFNDDTTYRQRSAWYLIKALVVLRLCSVNYLAMNSVPLMKRVEKILGSKLTYSILVKKSFYNYFCAGENDQELRDTVRKLSRNNIGAVLDYAAEADTEGFAPEPGVASGPDISMSSLVMKPNVQYPMDEGFFNENMKLYMMSIMHASLYSPRNVAGVTAVKVTGMCDPQLLARVSALLMSVHQSWCKHFTNEESLKLEECRVVMGVNRKHQLFITYDQLRAGFEKYNPSNKLSDAQFKEITEALDPRKTGKVNYFEYKEMLTNALIAVEPTPVQQALIEGLPQMSAKEKVLWKNVNNRLLLIASMAKELNVRMLVDAEQTFYQLAIDAIVATLQKTYNTELPVVYNTYQCYLTYAEDRIDNDLVRARHMNFHWGGKIVRGAYIVQERATAAQYGYTSPIWSTYEETNKCYNAAAKRIFDTFEAQPAKKHEVFFGTHNKKSLEIITASVLERPSIQSRVSFGQLFGMRDNLTVPLARAGFQVYKYVPYGPVKETIHYLGRRAVENSSILTTGDNETVMMIKELKRRCGF
The following text describes a protein:
Function:
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MASFHSHSPSPPAALSPDDAPQPRRPSRTSLHDAAAAAAPALSPESPGHELEDGADSSEFNADDVPVEVLVKHLLAAKQSLSSMTLVLRANDLATSARQMHQEFVILSAQTAFLRHGILQELHILHQLRRGMARAYDNGTRDFKHIIRTLDTADGRLEKIMQVLRKTTVENVFRQPGEEPKCLLDFVDPKIVEQVRDALKESIHELSAAKTSFDGDLLRFDTDLRTLTDAMAAAASLANPTTTTPDGYPPDQRSIPNLLSALSEGSHLMAEHLSSLTRHFDMCVTAVRTTEGGAALARRRAAEATSSDEDQAPVSISGVISAQESESGPSAFEPMDPLERQELLHVVMRDAAEVDDVVADIHNVLQQMEMDHASLHSLFSASRASHAATLTCFSMLEEVGARASSYVAAEAEFMQRWEDEKETIDENVSKMDELKKFYEGFLNAYGGLLLEVERRRAVEGKIDSIWRKAKEQVDKLVEADKREREHFRLEVGDYVPADLWGVVDRPLGRWAVVPLEDTREGSYEMEAHGEPENEGKVETAYERETEPSTPTPRKMPLNGPGSAGERPF
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Zona pellucida. Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MVASQCVLGFLLLVAVFSARPQARSFDQRMIMEGPHLLDNNFRGYWDQLQSPVKVESLRAPLASNLVSSVQSKQEMLSPVSSKVDWRFPLVREEPAQLDVNFQLRQPQTPNTVAVQCLENGVHVEVKQDFFGTGHLLEPSSFSLGGCGVLNVDTAAGVLIFQSALQDCGSQLVMTDDELVYVFTIDYKPAVLPNIPVVRSNSASVNIECHYSRKHNVSSSALLPAWTPYAATAVAEDVLVFSLKLMTDDWMYERPTNVFFLGDIFNIEASVSQYNHVPLRVFVDSCVATATPDVNAAPLYSFIENHGCFTDAKYTGSASKFLPRVKDDKLRFQLEAFRFQKEISGFIYITCLLKATVATQSLVNEHHKACSFIKNGWVSADGGDQVCACCDTSCGPRTAFTASQAGIQYEGRAQVGPFQIPSQSSGIKVVSF
The following text describes a protein:
Function:
Acts as a translational repressor.
Subcellular Localization:
Cell projection, dendrite. Cytoplasm. Synapse, synaptosome.
Sequence:
MKFRDQVSTLSDWFKGWNECEQTVALLSLLKRITRTQARFLQLCLEHSLSDCTEIHILETEANSAALISQWHQESKEKVISLLLSHLPLLQPRNTEAKCEYMKLLQKVLAYTTESNLYIEESRQLLSYALIHPATTLEDRNSLALWLNHLEERFSAGFSRYGRIETPSAHLRQDSDEWQPPVDPCMGEASLSWQDKPSRENGLMPFHSSNLVSSGIQNMGSNTVLACQVHPSPLKRSMSLIPTSQQAPGEWMGSEEVGSRSVFLTPDTAPLSPQSSVASSGSEQTEEVSAGRNTFAEDGSGMKDVPTWLKSLRLHKYASLFSHMSYEEMMTLTEHHLESQNVTKGARHKIALSIQKLRERPSVLKSLEKDILEGGNVRNALQELQQIVITPIKYYRPNQMDVTGSEQPPAQRPNQDLSCKGSDENEPPPGLTADCFQQQSTPACDSEPAVPPIAEGDLPGQLTRVLGKVCTQLLVSRPDEDNITCYLQLLEKCISHEAFTETQKKRLMSWKQQVLKLLRMIPRKALLEMQGYRQQKGCSWAFASNSLPIAGSVGSSIVRRGQRPFQMPPRAVPPSRINVLSPGSIGGVSPRHALTSPSTASQGRQNLWFANPGGSNSMPCPSHSSVQRTHSLPVHTSPQSILKFPPDCQVPGADLEINPRLESLCLSMTEHALEEGTDKTSTI
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MRKANLRTFVVSSYQPQDTSMAKSTDLKLKVTHKSTGTGKARKKKMALPRRIFRILESGKRVHFQNVSLSKKRQMCINRYLPVSDIAVASGRDNLQKNPVMCHSESARGIVGKSEMTVYRESSNIHKPYSAKNEKPTTSKDKGNRHREVVAIDCEMVGLGPKGRFAALARCSIIDHSGEIIYDSYVKPDEPITDYRTKWSGIRPRNMVNAIPFNEAQEQVKNLLKDKIVIGHAVWNDFQALKFAHPPNDVRDTSKCKLLAEIYGSKCTPGQHLGLKSLAKYLLGIDVQRGEHSSVEDARAAMDLYKLVEDKWEEELQSTFPDQDFRTSFLDDHFWPEDLI
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence:
MAATAVNGVAGTSSSGSAAASGAILQAAAGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDIQEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGINNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSFETLQIEKICRTCLSEEGDMRSVFSIDESIGETMRLFEMLMSCAAVQVLENDGLPNQVCLQCVHYITRAFSFKQLCERSDATLRQLLGKPMQATFMELKPLLSSDQHEPSFNDVINTVTENIQAVTDSVNEAFSSAVATVNSIDVGDSFKSEGSQDMKMKLEFVDNDVLGIDPDSCGSDAESKINELRAKRESKKKKIRDDTEQPIYPCEECTQCFTTMIDLKAHAKTHPKISRHICKICNQGFASASTLCRHMKVHDGAKRHLCSECGKGFARSDDLTRHIRTHTGEKPFPCKLCGKSFAQSFRLLEHMRAHANEKSFICSVCGKAFSRYTSLAAHNKTHSGIKSHACGVCGKRLCGSGSLAMHMKTHTGVKDHICPYCGKGFTTPSNLTIHKRTHTGERPYVCNECGKGFPDPSRLTVHVRSHSGEKPYVCSVCGRGCVSSSQLKKHRRIHTGEKPYQCNLCPKAFPRSEDLRIHIKTHTGDRNHICPFCKKGFYQASTLKVHLRIHTGEKPYTCNICNKAFSQTGPLSTHMKTHS
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Sequence:
MAEQPSRQQILQTQYNSYKSRLQQIAQKIVDLETDADEHKLVMDTLNSMDNNRRCFRMIHGVLVERTVGTVVPILKTTQEGIQTAMNGLLDQYKQLEAEFQKFQKDNKIQVVRQ
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSISSKPCSVDTGKSDSATSSSKNKPQKSVQPPRIKDNFNQLNLAIVGHVDSGKSTLSGRLLHLLGRISQKEMHKYEKEAKLQGKGSFAYAWALDESAEERERGITMTVGVAYFNTKCYRVVLLDSPGHRDFVPNMISGATQADAAILVIDASVGAFEAGIDATGGQTREHAQLIKSFGVDQIIIAVNKMXRDKTFKTCRFQGPCLLDAIDSLQLPQRDYSKPFLLPICDVVRAQSQGQVSICGKLERGALQTGNKVLVMPSREMATVRSLECDSQVCNSAKAGDSVTINLQGIDANHVMEGGVLCHPEFPVPVANHLELKVLILDNSIPILIGSQLEFLVHHAKEAARVVRILSLLDPKTGKETKKSPRCLLAKQNAIIEVVLQGMVCIDEHSNCKALGRVSLRSSGRTVALGLVTRIIGKKE
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.
Subcellular Localization:
Nucleus.
Sequence:
MPTLIALDASLSMLRPVPGRNEHTYQSLATKGIQHLLDNLTAAGKLEHVALLSYSTTAELKVDFTRDYDQVRQAVKKVEPVDKACLMSMLKAVVSIMSPWGNQNILQVVVFTDCGLGFGNTSITGFLEAYAEKESEPEFGFLKTLANYNLNFICLGLHGDYYFTRGLAVYQQLLDKVSLKGQLFMTKPAKSSDAVEGNPNPNPNPSHKSELGRTTVFELIERLCEASYKSSEVTLKCGSYFRMEASVLLWPPTAPYEQKSHIFGREPTIRHTDQKIEVCGFLSLSDIGSPATLSRHWVLPKVEREKSGSSRRSGNLSAAAKPPKLNLDTSNPNYELEKLEADIKEFYAKDSKDTEESGDDDVTIVLKPGPQTEQQKENLCVLLHGALKMENMAALVRVGDKWYGFIYAFTDSKKKSNLMLNILPPGTNVIPWLGDLESLGFPEDLAPGETASFPVRADRRSYSQSSVVWIRQASLQSDVQKVLRHAKKMPDKTQHFYKELNRIRRAALALGFVELLEALAMLLEKECAHLSLNGASNDCTLQLQHAATELRKTSNRDMKSMIVPLQKVGASDAGSTAATAPAPAYMY
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Histone chaperone possibly involved in H3/H4 deposition to the nucleosome. Associates with 18S rDNA chromatin and negatively regulates the level of its expression.
Subcellular Localization:
Nucleus.
Sequence:
MGFWGLEVKPGKPQAYNPKNEQGKIHVTQATLGTGLSKEKSVIQCSIGDKAPIALCSLLPNKIECCPLNLEFDDDDEPVEFTVTGDRSIHLSGFLEYYQDDEDDYEHDEDDSDGIDVGESEEDDSCEYDSEEDEQLDEFEDFLDSNLERYRNAAAPKSGVIIEEIEDEEKPAKDNKAKQTKKKSQASEGENAKKQIVAIEGAHVPVLESEDEDEDGLPIPKGKSSEVENASGEKMVVDNDEQGSNKKRKAKAAEQDDGQESANKSKKKKNQKEKKKGENVLNEEAGQVQTGNVLKKQDISQISSNTKAQDGTANNAMSESSKTPDKSAEKKTKNKKKKKPSDEAAEISGTVEKQTPADSKSSQVRTYPNGLIVEELSMGKPNGKRADPGKTVSVRYIGKLQKNGKIFDSNIGKSPFKFRLGIGSVIKGWDVGVNGMRVGDKRKLTIPPSMGYGVKGAGGQIPPNSWLTFDVELINVQ
The following text describes a protein:
Function:
Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSRPGSWDMDGLRADGGAAGAAPASSSSSSSVAAAAPGQCRGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERAGSASSSSSSAVVAARPEAPSAKECPAPGAAAAAPPGAPTLGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPANEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCAKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS
The following text describes a protein:
Function:
Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations. Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (By similarity). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (By similarity). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity). Mediates the non-genomic effects of androgens in multiple tissue (By similarity). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Major isoform.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI
The following text describes a protein:
Function:
Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not involved in dolichol production.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEDAAGEPGRCAAVLPAGGCGERLGSSTPKQFCTVLGRPLISHTLEAFERASWIKDIIVVVALESLDLMKAIIHKYGHKRVTLVKGGETRHRSILNGLKVFSENRSDGTANEKPEVVIIHDAVRPFVDEEFLLQVAISAKQHGAAGAIRPLVSTVIASSSDGFLDYSLERAKHRASEMPQAFQYDVIYRSYLQCTDYDLDFGTECLHLALQYSNVKAKLLEGPPDLWKVTYKRDLYAAESVIKESISQQLCIITNVNKDAIEVGFLLHESLKLHFKVKAVSSSMCKTIHHLQNIFHGQCCNFICINVKDSDFEETQNLVDLLQTTNAGISYPLVILSVHSTSEDYSSGINKLIGIRKLAKEAYKSNILVYGLLINIDQDKVQLQQAVCEGTAIITALIKDRNPALVGQIMVA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MEAERRNNEKSAASEGAIPLEVLDCAFCYHPLRPPVFQCRVGHVICSSCHHKLRKKDKCHVCSITGGYNRCIAFDHILESIKTSCSNSIYGCTVNTQYYKQEDHEKACPHAPCFCPEPGCGFVGSTTQLQCHLTHDHMLPATAFAYGYCFTLEMQEGMRVLHRKEEGGPLFLAKFTPVPPFGNAVSILCIDPHAMVGKHKFECHVDIYSRTMGWNQHSNFQIISTDLSNGFPGEEASYTFIVPNISSNPHTTTTRLLIRPPNITRS
The following text describes a protein:
Function:
Involved in auxin signaling pathway. Required for embryo development and meristem organization. Functions in the auxin pathway, integrating auxin signaling in the organization and maintenance of the shoot apical meristem (SAM) and root apical meristem (RAM).
Subcellular Localization:
Nucleus.
Sequence:
MLEYRCSSVDWKPSPVVALANSSDDSQVAAAREDGSLEIWLVSPGAVGWHCQLTIHGDPNSRISSLAWCCSPSIGLPSGRLFSSSIDGSISEWDLFDLKQKIVLESIGISIWQMALAPISGFSSDVEGIKNGYLSEKSNDEEEIGSEEDGSDSDEFHEKSEEEIDRILAAACDDGCVRLYRISNLEKLTYYRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGLGSSSEICVWSLLSLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLSGSTNGSQDLKPSSSQKWDYIGYVKAHTHDIRALTVAVPISREDPFPDDILPDKASRKHRKKGKPVDFTYHKWAHLGVPMLISAGDDAKLFAYSIQEFTKFSPHDICPAPQRIPMQMVHNSMFNKTSLLLVQGISTLDILRLNISSDSSGRASTKSLVRVKSRDARKIICSAISNTGSHFAYSDQIGPSLFELKKNEFTKCPWSVSRRRLPELPFAHSMIFSSDCSRLIIAGHDRRIYTIDISSLELVYAFTPSREEHEGEAPTPKEPPITKLFTSSDGQWLAAINCFGDIYVFNLETQRQHWFISRLDGASVTAAGFHPWNNNALVISTSSNQVFAFDVEARQLGKWSLLNTYVLPKRYQEFPGEVLGLSFSPSPNSSSVIVYSSRAKCLIDFGKPVEEDEEYDLPNGNLSKTLEGKLVNLGLKKGKGTNRKRRLDEYQLEGKSNERKNFEILPSNHPVLFVGHLSKNSILVIEKPWMDVVKSLDNQPVDRHIFGT
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MLPRFSFLDMQYNLSKKKFLKKPSRMFSQNSGTLPMYLPNIEELKQVFNKFDSNKDGKISPEEYKAVLKALGKGNLLTKEVQNIFEVADLDGDGFIDFNEFVEVQRKGGGVKAADLQRAFQAFDKDNDGKITVEEVHELLKKLGERCSLRDCQKMVRAVDANGDGVIDSDEFITMMTRTMTTY
The following text describes a protein:
Function:
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Does not bind methylated DNA by itself. Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci.
Sequence:
MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEEEEEEEEEEEEPEPERV