The following text describes a protein:
Function:
Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin-modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSALLNEIQRILGDLQSGKAASRNKGIQQLDEKLSSCREDLDKLFLSKTSDISWTTIFEASKEALFKQAGNLEDVNEKVFKTLAGKNYLYDNVLEKITQFNLEAGSQTSGNGHFLAKTSIFSAFEDGIKMRVVVKYFGDRILSLLEKGIYSSVSYVRDLKINEYSRILSYLFELNVDMDEVLRTRILKCITRTVSLAKDRVQLHVDLVEYLPELSSFALSAFGARKTEIVRVYLIFASELAVNYNHQLNVHMQEILPKLCEYHDEDAFRDDTRNLFFQCVSKSLHSMYLKMDMCDFNTLGVPVHEKWPQTLLRLKTIVNVEIRKNSWARCKNALLSNNKFSDPFIKMSALAMYIVLWHLETKKADENGEGDAPKKIPKPADKMETIFSLIDKKENTFNDVWLAIFTEILQLSSVILNVANYQMALTTVAEIMQMYGNAKNLRNLRLCLAHLLTKEQELLHSKSIREDFLGELWSQMANQLISETTTNSEEIKEKQLVLQMLIRHNKLNQKLSSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQADTFAISIINFLDVQQLRQISQSEHIVPSTERNLLAYKYNEQLICFDKDYATPFESITHIQSETKNCLIQSNYDCLMRGLNFEIAKENKPAAIIKNLNSLLKLICTMERLLHYKVFDADTYTGCPLIKRIGLYLSHIEFQLKANGAEILDKSDLPEILRLEIYVLDVFRTNLVLLDYLERQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRDEAFEHIVKVTMRWHPQDVLIVTKMLCSCQTISEASSSWLVSKLKTLFQQHHQDAELMDKVVQHMPTIFYFVRHKENHLDDMLMALNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRCPDIYLLENFAVICKSTAKFITMPTLEVRFATLFTFTILLESNCVTSDAIGHSRTHWDFCQELYESIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSSFHQEIALKELLHHCALRRLTEREFISLQSMSSCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCSKSISEELALPILASFLLIKNSSCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISMLHDPQEMMRLFGSLAICNRTASWYSLSGESLFKCLNFHIDPEMRPSMDSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVADAVYDAARKNETIVTQCSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNHFGDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHINLNSFLEETTDCEFLKPLREDCKSSQPNIDRADVANYLRSFLLSPTPERLRDLRTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLAQIGPLKISTVSYYFQTDFEAFEKSNGEPMEAFLGVVCHSLDTSLFQFDPKTHEGLVSVAIQVVNSKPGSNIMERYKNLRIFADKSTASTFLHSNKQIRRIDWLSILKATKSLSYEPWMCAFVSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIKLLLENSLEHVESLSQMLDYFFEGFTSSTAPNSQEIFRNKRAIKKFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSIMYLELWACSESPKSKADFLDNECFQDGAKKAYESIGCLDAIPGFVNPMRSRLDFLGHGSNLSTILLESDHLDRASGQLCIDIMKGNGLWSFAKLQQHQNIEPDYEIFWRLGQWDSLTDPKHQQNQTVVRTSLDLEQEFKRHHFVALRSIGQREEENSLSAIEQAYSCVRDILMEISVECLQSVYKYLTWLCSLQQAEDFCQIQFGTQLDPASTTKIFRKWQTELELKYGNFSCKEYVIAHQIALLKLAGTRASRRMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIKISVLLEDAEINLKMGNQQIAKAILDYVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTAAYATIAKYADREYQQLHDYRHSQEYQTLKDIIEQNRQTAEKVTQRENQDRRVISVQMKRYASLDEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGFSSAAIYRIISLWFTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERSGIARKIIAMICEKNGTAGECSKQLESLLPALITFANEGKTNDNRPVSDSVRNKQFDKVRRWRNLNAVHCPTLELPVMPSKEYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQSPQQSGEESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGWDPHL