lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MIGRSTRIIVQSRSVSVLSAVSKVEGKRKIKKDNGEVKDKKIKNWEDSALDRLEKELKEAGARYSRLQERRGNHSKLMEYAMKEDVSGIVSLAEATCGSRRELKWIQEERDQGCDMDMLMSLCLLVSSRIIGREMKDEGKVRSAAYGLANIVSTLRNSRPGEDTKASLILLWDSLYSLGDESINEILEETRPNLIKLIRSVDLKSSRVIMKENEKIQVRNRLLEWKINETDGEMTDDQYDSNLSLVDRLRTPMSFGEYLGNPYSIESLEKDELKMRFDRQMERDSKPWLEVPNVFLNEKSSLCSAEELIDTWEWKKEIEKVIKRKLAKKSGNHHVRNLLSNLDPTSTSEGLHKAVLSALGQGQSLLSLGSFQQSLAMPILSLSHSSFITTHRITDEQTMSDIFTDYSNYFTDTSISRVHSHREWWNICARKRGLDPTFDTPLHTFDNDSIIIYGEFVLEVVLEACEFPRGPRGTKTRVFSTKSVTQEEESLLREEGRIVSSKMLAIDPSLLKLLSYHQFRYLVFPCWQLPMEIPPRPWLDRGMAGPLYTTQNAAVVRNLPEFPKVDMGYEMRNRLKHKGQGRPVFDALNCLGSTGWTINRPVLDVLKKLFVMSNDPEKKGILANLSIPSKGDIISIPDSSKVVTQGKVDGVFSIEDKEKWREFYRQKEGALKEKNELNSLWYWMLYRLVLAEYFSSSTLFFPHNMDFRGRVYPISPLLNHMGDDVNRSILKFARGKTVGARGLSWLKLHCINLTGKLKRQSVEERMKVAEESVEKMIDSADRPLDGDRWWMESEEPWQTLAACIEVRDALRSPDPELFVSHLPIHQDGSCNGLQHYAALGRDRGGGSEVNLLPAPFPADVYSSVAVRVEEKRKIDETNGVEIALRLREKLKEPVPRKVIKQTVMTTVYGVTMYGAVQQIKRQLKALGMDGEEAAEFASYLAKHTFASLSDAFASSMQLKDWLRQCARGIGELMRPVEWVTPLGLPVMQPYTKSSRKKGKLVMMPITSKQENAYPPNLVHSLDSTHMMLTALHVSHKGLTFAAVHDCFWTHAADVDVMGVVCREQFVALHQEDLVKGFSGQMKDSYLPFVSEEEDKKKFDDLFSPKVDPGELDIKEVLKSVYFFS
The following text describes a protein:
Function:
Common component of the spliceosome and rRNA processing machinery.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTVEGVNPKAYPLADSQLSITILDLVQQATNYKQLKKGANEATKTLNRGISEFIVMAADTEPLEILLHLPLLAEDKVFEFLLIVSLSYESQLVVSLALASFTGFTWVSSSYDKKIRLYWLLDSSFEIVIVDNVPYVFVPSKQALGRACDVTRPVIACSVTSNEASQLKSQIQHLKDAIEKLLI
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular Localization:
Nucleus.
Sequence:
MGKHYCDYCDVFLTHDSVSVRKAHNSGRNHLQNVREYYQTLEPECIQQVLDTLAQEYDLRGIEKPRDLLQPAGSSFMTFGAGPLSGSSDRAFRSQVPPSRMSMGGGVGGGSDRRGDSRGGSGGYGRYGNNDGSRDQGAPPNYSRPPPQGGPYSRPPPDMMAGGPPGISNGPYPPRGPPLGYGAPLPGAYPSGPPPNMRGPPPPLASNGSHAPHSRTGYGPR
The following text describes a protein:
Function:
Delivers copper to copper zinc superoxide dismutase (SOD1).
Subcellular Localization:
Cytoplasm.
Sequence:
MASKSGDGGTMCALEFTVQMSCQSCVDAVHKTLKGAAGVQNVEVQLENQMVLVQTTLPSQEVQALLESTGRQAVLKGMGSSQLKNLGAAVAIMEGSGTVQGVVRFLQLSSELCLIEGTIDGLEPGLHGLHVHQYGDLTKDCSSCGDHFNPDGASHGGPQDTDRHRGDLGNVHAEASGRATFRIEDKQLKVWDVIGRSLVVDEGEDDLGRGGHPLSKVTGNSGKRLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGQGRKDSAQPPAHL
The following text describes a protein:
Function:
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGIDKPDPKTWKANFRCAMNSLPDIEEVKDRSIKKGNNAFRVYRMLPLSERPSKKGKKPKTEKEERVKHIKQEPVESSLGLSNGVSGFSPEYAVLTSAIKNEVDSTVNIIVVGQSHLDSNIEDQEIVTNPPDICQVVEVTTESDDQPVSMSELYPLQISPVSSYAESETTDSVASDEENAEGRPHWRKRSIEGKQYLSNMGTRNTYLLPSMATFVTSNKPDLQVTIKEDSCPMPYNSSWPPFTDLPLPAPVTPTPSSSRPDRETRASVIKKTSDITQARVKSC
The following text describes a protein:
Function:
May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=Mainly localized in the nucleus.
Sequence:
MDRLKSHLTVCFLPSVPFLILVSTLATAKSVTNSTLNGTNVVLGSVPVIIARTDHIIVKEGNSALINCSVYGIPDPQFKWYNSIGKLLKEEEDEKERGGGKWQMHDSGLLNITKVSFSDRGKYTCVASNIYGTVNNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMVLNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAADRDEVYTIPNSLKRSDSPAADSDASSLHEQPQQIAIKVSVHPQSKKEHADDQEGGQFEVKDVEETELSAEHSPETAEPSTDVTSTELTSEEPTPVEVPDKVLPPAYLEATEPAVTHDKNTCIIYESHV
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSYSKKDDDTDESVFAHVDQITVMQEARIFNQSPVSPKKCRALLEKLAYLVYTGEKFQEAQATELFFGITKLFQNKDPSLRQMVYITIKLLSGTAQDLIMITSSIMKDTATDRETVYRPNAIRALVRVIDANTVPAIERIMTTAIVDTISAASAAALVSSYHLFPIAKDIVSRWNNEIQEAVVSRTIGKQVGKSPFFTSSLGYKPSSSGISQYHALGLLYRIRRQDPVSISKLIQLLCGKQGIVSNPHALVMLIRYTGVLLQQSPHLTDSFVPILHGWLKGKSDMVNLEAARTLVRVKGLPEQFLQPVINVLKIFLSSHRSAARFSAICTLSELAMTRPHLVHSCNIDMENLLTDPNRSIASYAITTLLKTGNEESVDRLMQQISGFMSDISDSFKIVVVDAVRSLCLKFPNKYKAMLKFLSSILDGEGTYDYKRSAVDAIYDLMKYIPQSKEKALGELAEFIEDCEYPKLAVRILRILGEEGPKASHPTKYIRYIYNRIMLENAIVRSAAVSALTKFGTDAENEAVRESVKTILSRCLDDADDEVRDRTVLSLKVLDNVETLTPVVDMKKIPSLSALESKLVDYLLNEKFDDAFDLNEVPVLTQDEIDAENYKAKKASTEAVPVEPEEEAAAEVVEKPEVLVDTYNKIFQSIPEFSNYGDILKSSTTPVELTEKETEFVVKTIKHVFKDHLVVEFQLQNTLAEVVLENVVVVSTPSNDDLVEDCVIPAPRASQKEPVSIYVSFSFKEPYPTVTLNNVLKFTSKEVDLHTGELEEEGYEDEYEIDDLEVDSGDYLIPVYEPDFSGAWESLSSSEGSAVYVLSNVHDYFETCERVVEMLQLEPLEGSEHPMEGERVHTLKLSGKTVTGDKVLATVKMARAKDNAGVAVKITAHGESQTAVDLVLSGVA
The following text describes a protein:
Function:
Virulence factor that suppresses host Toll-like receptor 2 (TLR2)-mediated NF-kappa-B signaling upon infection. NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Able to reduce NAD(+) levels in host cells.
Subcellular Localization:
Secreted.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MSVLETKLKSQMSKSAKIARNMNKLPDEIDRLRKRIERINKKRKPTSSNIRDLEKSNKQLVTKQQKLADLQVEYTKIEKKINETKINLQKEQSRNQKKLSSMLDKNTKGNEEIMEKLLTNSDQINEISNQIKKAVNQKEIIEYDVFLSHSSLDKEDYVSKISEKLIEKGLKVFEDVKVFEIGKSQTETMNMGILNSRFVVVFLSPNFIESGWSRYEFLSFLNREINEEHVIILPIWHKVSVEDVRAYNPYLVDKYALNTSDFSIEEIVEKIYQVIVNSKN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Subcellular Localization:
Nucleus, PML body.
Sequence:
MEPHGEDEQPPPREPWGRLLRLGAEEDEPQILLWKREWTIGRRRGCDLSFPSNKLVSGDHCKLRVDEKSGEVTLEDTSTNGTVINKLRVVKKQTYPLQSGDIIYLVYRKNEPEHNVAYLYESLNGKQSLTQESLGPGTISISPKECSSLVANGELSSLSSVFQDNEASFSLLKTEDTEELEPAKKKMKGDGELDLNLQLSVADQRGIAQTSSEDVKDASVKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSSLCPTCRCPVERICKNHILNNLVEAYLLQHPDKSRSEEDVRSMDARNKITQDMLQPKVRRSFSDEEGSSEDLLELSDVDSESSDISQPYIVCRQCPEYRRQAVQSLPCPVPESELGATQALGGEAPSTSASLTTAAPGYTCPLQGSHAICTCCFQPMPDRRAEHEQDSRIAPQQCAVCLQPFCHLYWGCTRTGCFGCLAPFCELNLGDKCLDGVLNNNNYESDILKNYLTTRGLTWKNMLTESLLALQRGVFILSDYRITGNTVLCYCCGLRSFRELTYQYRQNIPASELPVTVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQTRFKN
The following text describes a protein:
Function:
Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Promotes clustering of HT2RC at the cell surface.
Subcellular Localization:
Apical cell membrane. Cell junction, tight junction. Cell projection, dendrite. Postsynaptic density. Synapse, synaptosome.
Sequence:
MLEAIDKNRALQAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHIPHLSPAVIPTLQNESFLLSPNNGNLEALTGSGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAVSILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHVETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEEHTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQESELMSREDVTKDADLSPVNASIIKENYEKDEDSLSSRRNTNILPIEEEGYPLLSAEIEEIEDARKQEAVLLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDADQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEEGLADKPLFRADLALVDTNDADLVDESTFESQYSPDNDSIYSTQTSILSLHGSSCGDGLNYGSSLPSSSPKDVIENSCDPLLDLHMSLEELYTQNLLQRQDENIPLVDISMGSASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLASNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAVGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGKIMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRSRKSPLPSLPHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKTSQDVDKEDEFGYSWKNIRERYGTLTVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSTSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLRGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPVEKFISLLKTTKTTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEIKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLEQGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGVGMSKLSSLAFSGPGVLFHVSDRYSGMHLICTKMFLNFDY
The following text describes a protein:
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling activates adenylate cyclase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MALSGQDWRRHQSHRQHRNHRTQGNHQKLISTATLTLFVLFLSSWIAYAAGKATVPAPLVEGETESATSQDFNSSSAFLGAIASASSTGSGSGSGSGSGSGSGSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMRENYYQDQYGEPPSQRVMLGDERHGARESFL
The following text describes a protein:
Function:
Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAPKDSASIDVGYPIMGIKFLNNKTILVAGGGGEGNNGIPNKITAIKSSFKVKDPNRKLQRFREITLPSNEDSPQCIDTAKLVGENKFNVVLGCNQSSQLIKSMNINNNIRKYEYTNEEHLRFVDAAQFEAEINGDADDYPKIVRLAQNNNVGCFMTSIVPSSIYIFNPETLELNYKFIPDKSIEIKDFVLSPHDGNSLCYITSNSINVVATNNTSNVELSSVSIPNLDKQLKGYVLSKVRYINSDELLLAATFVGKKGAVLLRLNIPNKKIIQTQVISKKGVIVSMDVSPTKVAVATNDLALTLINLSNLKVLKAFKNLHSWAITSVSFSPSGDKVASVSASGTLVVSKISSIGRSGGSGWFLSVLLALVFGIVAILAAVFPDFATQLTGQSSLIDYKFFDFAVPVSIVAEKYSSIVSQFLDTKSTTVSSVESKILDNTPSAEIPTTESTFLQSVDHQDPIIDSSEVESADVETTVIEVVVEETTVVENSSVETSIIPSEVREAHTEKSSSIEESHVPSTFIESDVVSSTETSSSVESLVESPVVESSVEETPIVESSPVQPPIIEESSSFELEFSESTTESQVVQSSVIESVEEESSLEGTTIIESQSVEPPVVESSSSEISSVESFSSEPANVESSSTESSVLESSSVRASYIESPSVESLPVESISVESPSTESPTAESMSVDVSSTEVSSSESPSTDPSSESPSPDVSTVESARVESSSVENPSVETSSVETPSTETPSTETPLTETSSTEPSSAEIPAVESISSESLSVETPSIEVSSAESHSVEPNVTESLSVQSSTAESDTAPSSITSASTKKARVKRTITKKVTRTIKKDEL
The following text describes a protein:
Function:
Transcriptional regulator that can both act as a coactivator or a corepressor depending on the context. Lacks DNA-binding domains and acts by associating with other transcription factors such as rotund (rn) and squeeze (sqz). Acts as a coactivator of sqz and is required to limit the number of neurons that express the LIM-homeodomain gene apterous and to specify Tv neuronal fate. Acts as a corepressor of rn in wing development and is required to limit the expression of wingless (wg) in the wing hinge, where wg plays a mitogenic role.
Subcellular Localization:
Nucleus.
Domain:
The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Sequence:
MEASSNPTTPTTAVATTTSTSSPSPAASTSSKGHSQSATASASASATQSQLLTTSLEMPKTEDLYNLSVASGLSEGQRSLSGAPSASSSPIMSPQGKIFGRNANGTMITTSRPGNEAEVQLYRVLQRASLLAYYDTLLEMGGDDVQQLYDAGEEEFLEIMALVGMASKPLHVRRLQKALHEWANNPGLFQGPMMPHLGLCETPPKPALIFNPDTTPALPRQKFPSFNPSGSSFMPSPVPPAPLPASASVPAPTVPLATQISCPSAPSVPLPLVLPPNPLTSSPHPSANSNLPANTAHQVSSSSPQLTPVLTEAQIQRITMCADKIGRQLPQREPRAQTTRKRTTRELEQVIAMGEQDPRRMDEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQLCRNPQTIWLLTRRDELFPLARQIVKDAGFGHSASIARYGGLLTQLPSQGAGLGGGRAPGDTDCESSDAAVPSKRQRLSSTEAAQLPLDLNREAVEDSRYNLFAMYQKFAKPPFDLSEIAKFSVSKAADYEDNDSRFSFSNSSSPTMPTPCNGMEGERSPVSRQMETSSPPRESVDLSGTSSGAALSGVQVISAAGDNIIAVANPALALSPALNEVLALKRSAASPET
The following text describes a protein:
Function:
May be involved in the transport of sterols.
Sequence:
GNRGNVDRTAVLTAPLSFDGESQVDYRAPNLLQRILSLLGNVRPGSDLTNFQLPPLFNIPKSQLQCFGEPLYCTREDMLSRCCSAESPLERLTSVVAWSISITRPLIFGVAPYNPILGETHHVSRGNLNVLLEQVSHHPPVSALHATDDREELEMIWCQHPVPKFYGTSVETEVHGKRQLKLLRLGETYVMNSPKLLIRFFPVPGVDWVGNVRITCQGTGLGAELCYRGPSLMGRNRRSIKGKIMDLSSSKTLYEVDGHWDSTVTVKDVSNGKQKVIYNAAEIISGSKTPQVKDSKCVLGSESAVVWSEVSRGILSKDWDRAREAKKAVEEEQRKLKKERDSRGETWVPKHFTVSYDKKNGWDCLPIEKSVPSAPIHVPFDC
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MKIGKSILLLLVIYIFSIVKSIEIHKNPNIKNSNVKNPQKNPYSKDDIGGDKEDKTLKKIQVGRNGLNDTLYWGTYKPQQYFGLKTRSIEPINTGLIWSTPNINYGFNRFNYKTSQGGDGVASYKWLKHDGKNFGVQEIQDSKGNLNLTTSFVKKSGKKGGDWSIRVSGKTNETNINSQPITSLIYFIHDESIKRSRGETNFLSVQNHKKGDTDNINGDLQIKGEHKEIGKYTLYFSDISNKEKQQETLKKYKLVDEHPDIEGWRYYGVSKFTENNWDILPTIFDMTTKIHLNPVADKWVKDQRKIIIPTLPNIINEKSNIIAIQRVLTVPFDVVEEIVKSLFVGSNFDNLFNQHEKQFDDKFNLKFNYEKLRKHPEYVYKVTKESLSSLIGGFGYWYGSSLFESSSGRFLKTKPVALYSATPSRTAFPRGFLWDEGFHQLVVSSFDIDLTIESLSHWFNIMNKNGWIPREQILGREAQSMVPDEFVKQSPIIANPPTIILAVNKLIELAEVHKKAGHKEEFDKIFEFINEAYPRIQRFYQYYWKTQKSGALENAFRWRDRKVNHTLASGLDDYPRADIPSDAEIHVDLNSWMAFFAQSLAKISEFIDKKEDTVTYQNQFNAIFKVIEDYHWDPEENLFQDILLHPNGTKEFIKTYGYLNYFPLMLGILPEDSPKIPPLVSTLKDVNGIWSRWGIRSLSIKDKHFGTNENYWRGPIWININYLFTHSMYKKYMKNSLSVSDLYISLRFNLLSNVGKKYIETGFFWEQYDPINGNGQRNHPFNGWTSLISLIISEQY
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MYCCALRSCSVPTGPATTFCSFDKSCRCGVCLPSTCPHEISLLQPICCDTCPPPCCKPDTYVPTCWLLNNCHPTPGLSGINLTTYVQPGCESPCEPRC
The following text describes a protein:
Function:
NHase catalyzes the hydration of various nitrile compounds to the corresponding amides.
Sequence:
MNGVYDVGGTDGLGPINRPADEPVFRAEWEKVAFAMFPATFRAGFMGLDEFRFGIEQMNPAEYLESPYYWHWIRTYIHHGVRTGKIDLEELERRTQYYRENPDAPLPEHEQKPELIEFVNQAVYGGLPASREVDRPPKFKEGDVVRFSTASPKGHARRARYVRGKTGTVVKHHGAYIYPDTAGNGLGECPEHLYTVRFTAQELWGPEGDPNSSVYYDCWEPYIELVDTKAAAA
The following text describes a protein:
Function:
Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MASLRAERTPGGPRLPSTRAGRPAVLRLLLLLGGERSAPGPGREAREVREALEGRGAGRLRPKWAPGASADSSVLRAVPGPTAVRAQRELLPTWGKLGCWGPRRGLKSSWAGEEGGDLGLDESGKELVPAPLFLALRYPVGAWIIPLSLLSSPDFQGPPSPTTPPHLQAPLPRSLPSHLPLPFLPTAVLKPQESLAQLLLTPGSLESEGKTVENYETNVQLCWQEYKVYMDSIQKDWCDWAMISRPYSILQYCLEQTAEGFGLGFPNPWAERIIFETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLVTLVVWRSKDSEAQA
The following text describes a protein:
Function:
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
Sequence:
MPVEKVMKRDGRIVPFDKERIRWAIQRAMLEVGVRDEKLLNRVVRRVVRRVNELYDGQIPNIENIQDIVELELMRAGLFDVAKAYILYRKKKAEIREEKKKILNKDKLDEIDKRFSLNALRVLASRYLIKNEKGEIIESPRELFERVAILAVIPDILYDERVFDKNGGHEQDVSAIERYRENLDEYDGKFSIGRFRLNKWHFERLLNLYRELAEKGQMKLPIDEVLKMLENGAFDNYEDEIEEYFRLMTGQYFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKAGGGCIDGNAKIIFENDGEEHIMTMAEMYERYKDLGEFYDPEYNRWGINVEEVPVYVKSFDPSTKEITKGKVKVIWKYELGEDVPKYEIKTNKGTRVLTSPWHPFFVITQDLKIVEKRADELREGDMLVGGMPSDDDYEFLLDYWLAGFIAGDGSIDKYRSHVKGHEYVYDRLRIYDYTTETLGIINDHLEKTFGKRYSLQRDRNIHYIDIKAKGITSHYIELLRGITNGIPQPILKEGRNAVLSFITGLFDAEGHVNSKPGVELGMVNRKLIEDITYYLNSLGIKARMRKKPRKDGVDYVMHVEEYSSLLRFYELIGKNLQNSEKRIKLEELLSKHNGGSFGLTLSFEDFKAWSSKYGVEFKTNGSQTLAIIKNEKVSLGQWHRRGRVSKAVLVKMLRKLYDTTKSEDVKRMLHLIEGLEVVKEINVTNEPKTFYDLTVERYQNYLAGENGMVFVHNTGLNFSKLRPEGDLVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEVWHPDIEKFIHAKEKNTGTNVLSNFNISVGLWEDFWEALKEGKRYPLINPRTGEKVKEIDPKSLFEELAYMAWAKADPGVVFFDVINRRNVLEPAKGEKIRATNPCVVGDTRVLTPEGYIKAEELFSLAKERGKKEAVAVEGIAEEGEPYAYSVEVLLPGEEEVKYETVHGKALAIADPVAVPAYVWKVGKKKVARVRTKQGYEITATLDHRLMTSEGWKEVGELKPGDEILLPRFEIEEDFGSESIGEDLAFVLGWFIGDGYLNVNDKRAWFYFNAEKEEDIAWKIREILAKHFGIKAEPHRYGNQIKLGVRGEAYRWLESIMGSNEKRVPEIIYRLKPREIAAFLRGLFSADGYVDNDNAVRLTSKDRGLLRDVQDLLLLFGILSKIYERPYSSEFKYTTKDGEERTYRAEGYYELVIANYSRKLFAEKIGFEGYKMEKLSLQKTKIDEPVVTVESVEVLGEEIVYDFTVPEHHSYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKYDDEGKPYFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDRNTKLTRRIGVGMMGLADALFKLGIPYNSKEGFDFMRKATEYLTFYAYKRSVEAAKERGPFPLYEKTRYKDGELPVEGFYHREIWNLPWDELVEEIKKYGVRNGMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLWSDEILKKISDNYGSVQGLEEIPEDMQRVFVTAMDIHWLDHILAQANIQLWLTDSASKTINMPNDATVEDVKAAYLLAYKLGCKGVTVYRDGSLSVQVYSVEGEKKKRVPAKPSDYAVEKLKTIVEAEPWLSRFINVEAILNGTNGKEKSAQAGGLTFSVSHVSAVKPAHEHSHHAKRPDIPEEKIRELLGVAYCPVCYEKDGELVELRMESGCATCPRCGWSKCVIS
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MKIQLFFFILHFWVTILPAKKKYPEYGSLDLRRECRIGNGQCKNQCHENEIRIAYCIRPGTHCCLQQ
The following text describes a protein:
Function:
Catalyzes 3'-non-homologous tail removal of RAD1/RAD10-dependent single-strand annealing recombination intermediates. Plays a key role in targeting RAD1/RAD10 complex to 3'-flap cleavage substrate in recombination. Also contributes to the integrity of ribosomal DNA arrays.
Miscellaneous:
MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MAPSIATVKIARDMVLPLRIFVNRKQILQTNDKTSNKSNATIFEAPLLSNNSIICLKSPNTRIYLSQQDKKNLCDEIKEDLLLIVYELASPEIISSVLSKIRVGHSTDFQINVLPKLFAGADTDNAVTSHIQSVTRLAKFKYKLHYKHKWELDIFINSIKKIANLRHYLMFQTLTLNGFSLNAGPKTLLARKIEKQPQVPNLLIENGDADALDTPVEEDIKPVIEFMYKPVINLGEIIDVHVLHRPRRHKVRTQSKQPQEE
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Miscellaneous:
MISCELLANEOUS: The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.
Subcellular Localization:
Nucleus.
Sequence:
MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDASGKGAAGFEGKLFVQTIDARDENEEKYMRAYRAFEETTAGLSDKDFHDLLSSLVSKEKQHEEISLALVYIILTDPSSAPKTYRDLTLLTRDGLGFVTANLAMLVAEKYHKLTDVGRKQLLWLLRELIKNQVLNVDNLAWNILRQASGGDISPKNVALIEGLLDIFTEHRAWLEKDQFLVGTVAYTFVRLIEDHFGPQFVHLRNREVKFVISLIRDRFMDIIPLGREFVRLLQNVGRIPEFDQLWKDMLYNPKSLCPTFNGVWQLLQTRTSRRFLRGRLTPDIERKIHFLTSNVKFGNQKRYQDWFQERYFNTPESQSLRCDLIRFIISAIHPTNDMLCSDIIPRWAIIGWLLTSCTNAVTLANAKLALFYDWLFFDPAKDNIMNVEPGILVMYHSIKNHPLVSCTLLDFLCRIMKNFYPKWEDRIRTGIYNSLRKILEMKVIPNLVPLFESPKLDRELKGMLRETFREFCVPPNSMYMHPGPPQPGMETPMMMHYPGPGGGEQVEQHPPHLMHPAAKAASTAASADDPKFSDDEDDATTKPATTTTTTTTTTKTEDVSDDDDLPLAKVRLLEKPAIAKVALPDTLNGHLEEFLREKSVKTFEPLLQCLGSCGKAALNQEQENYLTESVISVIKQTLPDKSYFPASKTDDNLSESINYPLFAAYRLLYQQEDSCKKRVMALLVAIVTRVSVAGYMLLYFLKVHGKLQGRRKETAGGSTAFKASVYGVLCDALDSVDSVDECIEKDLNLLEKHNTQMFLWILPDMYREFKQTMLNNTTVLRLLVGCIDANNLGDIIYSITQGKLILFDEDGIVEILRKSLEYETFEQVCIWQLVQAHDIPLETFQEIIPELESGAHAEALTAILLLLRAEKPTTELVRLLLSRETESKHRGDPFVTSVLRYWCQEFEEKLSELIAALLTSKYPSNSPNKRKRPSKSAQQNTAPTSEQLLNHLEHFRRSCRHGNGTGTGLFVQNDMQRALQQAFTHSSESQRKQFSDLFALAAEDETSTTVGRRGTSSRGRKAPSNKKETAAEKAAAAAAAAHANNSKKAAEASAKFSDDSSDEDWSKQKASKRRKTLSDSD