lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription coactivator that associates with the serum response factor (srf) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The srf-mrtfa complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Mrtfa binds G-actin via its RPEL repeats, regulating activity of the mrtfa-srf complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Subcellular location is tightly regulated by actin both in cytoplasm and nucleus: high levels of G-actin in the nucleus observed during serum deprivation lead to low levels of nuclear mrtfa, while reduced levels of nuclear G-actin result in accumulation of mrtfa in the nucleus.
Domain:
The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity; The RPEL repeats mediate binding to globular actin (G-actin); each RPEL repeat-binding to one G-actin monomer. In addition, each intervening spacer sequence region can bind one G-actin monomer, to reach a pentavalent complex.
Sequence:
MTLLDTEQALLAIHTVLQLKLQQRRTREELENQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERAELVRMHILEETSAEPSLQAKQIKLKRARLADDLNEKISQRPGPMELVVKNILPVETSLKEVIIDVDYPEVVDNSSFDEDSSDALSPEQPASQESQGSIPSPIENRPSETTQIPALSPSHAFSCVQFGTDAFNQDSLQSTAITISNGLTASICKSLPALVKQSQPKPSFEKSQRIKKPKEPKPKVKKLKYHQYIPPDQKQKGTPAMDSSYAKLLQQQQLFLQLQIINQQQHQHYNYQTILPAPPKPLPDQQNTNSSSTTTVRSMSTVAPSTLATPTITRQNSNVAVGGRTGPLPHNLDEMKVAELKLELKHRGLPVSGTKIDLIERLKASQDPSTATAASAKPTPVQQAKPPEVVPIVSSSCLTTREPIKLCSTSSTPPGSPCPSEVSVVSMDEVSMISDALGETVACPVTQQVQQNPAAEKSPPDARDKDLMLREKDRQIEELTQRLKQKQELVERLRQQLEQEKRTPQHSTDDQQALILAVKQEPLPLTVDSINKKASSIVKQELNTAIICQQEPQLLIGPVSSGIEGKVDNSAGTKLVFTLTNPSSQLPEENRQIVLQKVPTPPSSLHPNNSLPKQEVLLSCCALQNQKPALQLVPGTVLSLSSSNLQPMLNMNGFQKWHGEALDSLQKQLVHNESPATPPQQPEPEPPPHSIFLTHSSPQWSKNPPGYDEAMKQQPNSCEDGRPGCLQAVDFFDVLIKNLDIPSEFKDYLVPCLKQTSPSHQAAQMVPQVEMAPPPSPIHSALGRLEDFLESSTGTPLLRGHQDGPSSMPLIDDLHSQMLSSLAILDHPPSPMDTSDLHFSPIGNSLGLDISEPPLDGMDWLELSEPPAMNLTPLSTFTPSVFSTDFLDSHDLHLHWDSCL
The following text describes a protein:
Function:
Potential disease resistance protein.
Sequence:
MGKDFKSMVTRCIYVGKENDNVKKLKTATEELKDLRNIVMKRVKMYEDQQKLKRLEKVQVWLRQADVAIKEAEEMLITLMSSSSSNGSSMMSFHKLDKKLCKKLKEVQEIKSRGTFDVVVENSGIGSGSMMISNVDRDDQTVGLEAVSGLVWRCMTVDNTGIIGLYGVEGVGKTTVLTQVNNRLLQHKLNGFDFVIWVFVSKNVNLEKIQDTIREKIGFLDRSWMSKTEEEKAGKIFEILSKRRFALFLDDVWEKVDLVKAGVPPPDGLNRSKIVFTTCSDEVCQEMGAQTKIKMEKLPWERAWDLFKMNAGEEIVKSHPDITKVAQEVAAKCDGLPLALVTIGRAMASKKTPQEWRDALYILSTSPPNFSGPIL
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular Localization:
Nucleus.
Sequence:
MGPAEELVRIAKKLDKMVARKSTEGALDLLKSLTGYTMTIQLLQTTRIGVAVNSVRKHCSDEEVVASAKILIKNWKRLLESSAPAKKEKDADGEKEKKEKEKRLDVPNPTEGANPHPAKHPKSPTEKHREKHKERKPSKSGSHAAPPKGHPTDPNPEREPSARRSPTAPSKKSPLDGKKERRDSADSRSSAASSSSSPQKRPSGERRPSVSANPSPAPSSSRRSSSDSNGDRANSSKGKAETPRTPGSPSFSPSICLLPPCYLTGDSVRDKCIEMLTAALRMDDDYKEFGVNCEKMELKSTDMKYRNRVRSRISNLKDPKNPNLRRNVLCGAIAPALIARMTAEEMASDELKELRNAMTQEAIREHQMAKTGGTVTDLFQCGKCKKKNCTYNQVQTRSADEPMTTFVLCNECGNRWKFC
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSALSYKKNDDIESGALDKMTVYQECQRAFAESPINARKCRKLLAKLIHLLTIGETFSEFEATGLFIAVSKLFPHKDPSLRQIVYLAIKELVPLSNNDVIMVTSSITRDVQGSSDLIYKPNAIRALARVIDGSFVQGIERLMKTAIVDRHTSVSSAALVSAYHLLPIAKDTIRRWAAEVQEAVTSQKNFPAVTLPNYAPGPAVLAPYHALSLLYELRAHDRMALIKLIQQFSGASAHLQSPNANVMLIRFIAKAANDGAHRQQLVALLERYLGHKSDMVALEAAKAVLTLRDVSPKEAASAIESLRAFLASPRTIARFAAIRILNRFAMTNPGAVAVCNAEIQPLITDSNRSIATYAITALLKTGNEASVDKLVTQISGFMSDITDEFRIVVIDAVRSLALKFHAKKSTMLQFFGNTLRNDGGSAQYKAAVVAALFDMIRYVPDCRDTALGILCEFIEDCEYTEIVVSVLHTLGQEGPAAANPTVYIRYIYNRIVLENAFIRAAAVSALAKFALVDDTSVKKSVKVLLERSLEDETDEVRDRAVIALKLLESGDQAQAKAYISPESRFSLPILEHKLALYVTGSGADFDTPFDMSSVPLITDQEAREAALKAHRETTEATPVVNGGAGGPTPASAAAATTANLASKSNSHEAAIQRAEKYAAELAAIPDLAAFGTPLKSSLAVALTESETEFVVTAIKHIFPSHVVLQYDVHNTLPDAQLSNVSVVASIEDDSEELVEEFILPVDELGPDSHGTVYVALEKTEDHLAVASFENILKFTLHDINKTTGEVSEDGDEDEYQIENLVLGAGDYLEGGFIGSFDHLWDELANTEAVDTATLSEYKGLEEAVQFLISQLSLTPLESSDEVTSASTHTLKLFGKTLTGEKVIVQIKMAASQRTGVVVQCKARSGDEEVAELVAGFVGSL
The following text describes a protein:
Function:
May inhibit BMP signaling.
Subcellular Localization:
Nucleus.
Sequence:
MESIPNQLPAGRDSSCSPNSKDLQSYSGPPLKPNQVSETSLYGIPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGAHSPPKLPENFAFDVSHECAWGSRGNFIPARYNSSRAKCIKCSFCNMYFSPNKFIFHSHRTPESKYTQPDAANFNSWRRHLKLSDKNSSDDVIHAWEDVKAMFNGGSRKRTLPIGRSESSPSQPPRGQTQGEPSDVPHKTLRCEDDRVNVTMPSSIRSYPVIPVPSKSFGMLQKIPPPLFPHPYGFPAFGLCQKKDDGEVMGEPNKTNLSGVFWPSPKDSAYTSFPMFWPTTGSLAMPTYHHAQPKPPSDVLCARHNELDVSEQSDRSTSTPKDSLLDNERCSSTQSTRNEEDKSGDESRSIEGIPPTSRKISYISAFRPVVKDVESIAKLYGNRGPYSGPRSGYMSPDFLSESSSYRSVSPDVDSVDDPDVDVESHKAHEDEECLQLSVDDRRSPHSLTLAQSEGVKGQDQENTQMHTLNDLHSTNSSETRPSDMESHGNKHTTRFEVYARERDEHVHQMSTSYFGSATTYQRETSVKDVHEEEPSSTVEEMEPKNHQDENNISEERLKEPNDVCADEEAICKDTGNRGSLIEKNIESMAKEELQKQLVEQVELRKKLEREFQNLKDSFQDQMKRELSYREEMVQQLQIVREAHDALHHFSCKMLTPRHCTGTCTFKPPLLPP
The following text describes a protein:
Function:
A humoral factor that may play a role in stress tolerance.
Subcellular Localization:
Secreted.
Sequence:
MYFAIRLSFVLAVLFCLTGNGSARMLDADRNRLQQLQIRSQQSADANTQVDIAYEVIGIYDKYKGQGGSNVLREAQLNSQVNDFKRKTMVIDGVPAQGGVWGILGAIKKAADAVPDNVKKDAENLVKSSTKVLVRGIYDYLMGKMKQH
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTSKRQYPIDQSNQLSQGQNPSPQQPLQQYPQQPYQPNPTYGNDTTQQWNQTPQQQQQPQQQNISPPQSQNQNGVQNTIHTGGSKRVYPVDPQNETLLSSNFSNMNLSSQQQQPLPQPTHIPVPGPNTTTYNPYIQQPQQQPQQQPQQQPQQPQQPQQQPQQQTQQPQTWNTSPPQTQQQPIQTFTPHISPPQTQQQQPQQTTPFQPMQPTQPSYSQPQQTQPLPLPPMQPSYNQQPYTQQPYTQQPYTQQPGQQSQYQQPQQQTPQQQAAVEQPVPTLENLCPKPFMRLSMNAIPNHPSILNKVHIPLGLNIHPLAHDPQGPVPVVYSSIIRCRRCRTYINPFVTWLNGGGRWRCNMCENINDTPQDYFSPIDFTTGKRSDILNRPELQKGCVEFLASSDYLVRPPQPPTYFFIVDVCYESIVSGMLNTAINAIKTTLGDLIEKSNGRARFGIMTFDDSLHFYNLKSNPSNRPQMFVVTDMDQVYVPPFEDFLVNLKDGLEVVENTLNIIQSMPRTQQKVESCLGSALKAAFSICERVGGKLIVLQSYIPRGPLGKLSIRDYQPLLGTKKESTLLQPSNDGEFYKELALSCTSQQLSVDLFLFSNDYTDTASLGTLCQITGGSMYYYPSFVASRDGQVFAANLIHSLTRDTAWEAVMRVRTSRGLTINSYHGNYFLKTSDLLGLPTIDSDKTITLQMGISDSIGQKYASLQSALLYTHSCGERRVRVFTISIPVVSNYQDLFRYADISVVTSLISKMAIDKALSSSLNDARDAIANKCVEILQAFKAASTSNPQANPAVTLSQNAPKLLLPETLKHLPLYVVSMVKSIIFSSRTTHPDLRAFHMQRMKTLDLNSCLNFFYPYFYSLLAPPNYQPPTTPNTPFVPHSFKLSSDELQRNGLFAIVNGYTLYLFIGEQLPQPVFTDIFGVPDVSQLDINTFQDLPILDNDHSRYARKVIELVRNSYPEYLKMFVVKSTDRQRRPEFQSLLIEDRTPEGCSYYEFIIQLQSRITQN
The following text describes a protein:
Function:
G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to bigLEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception. Acts as a negative regulator T cell function.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus.
Sequence:
MTNSSTFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKITVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTYSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMIIPIKDIKEKPNVGCMEFKSEFGRNWHLLTNFISIAIFFNFSAIILISNCLVIRQLYRNKDNENYPNVKRALISILLVTTGYIICFVPYHIVRIPYTLSQTEVISDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKITETFASHKESKAQKEKPRSENNA
The following text describes a protein:
Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Sequence:
MSGESPRSLGKGSPQPGPVPLGVIRLYSMRFCPFAQRTRLVLKAKGIKHEVVNINLKNKPEWFFKKHPLGLIPVLENSKGQLIHDSSITCEYLDEAYPGKKLFPEDPYEKALQKMNFEFLSKIPSLAKDVIIAIQNNEHGTPKKEELCNEFNKLEEVLNRQKTTFLGGNSVSMIDYLIWPWFERLELYEIPNCLDKTPALKLWVVAMKNDPIVAALLTDVKTFKGFYDLYFQNNPDAFDYGL
The following text describes a protein:
Function:
May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport.
Sequence:
MVARSTDNIDTTGEGQVRSLGNATSNVKGKPTKRLSITRGHFPKLTECAHFHYEAVDFGHIQLQLAPEQNENLSNLEEGDQLFPVQVTCQDKNWQVHRSYEEFHNLDAHLHCCIFDRRFSQLPELPSISHVRAHPEMLVPMLSQYLEKLSDLVDSNINCGPVLTWMEIDNHGNRLLVNEEASINVPAIAAAHVVKRYTAQASDELSFEVGDIISVIDMPPKEDRSWWRGKHGFQVGFFPSECVELFAERPSPGLKTDAEGMSGGIPCPPGLLSPSSVSKKHGKLIGFLRTFMKSRPSKQRLKQRGILRERVFGCDLGEHLKNAGSDVPQVLRTCSDFIEKHGIVDGIYRLSGVSSNIQRLRHEFDCERVPELSKDVYLQDIHSVSSLCKLYFRELPNPLLTYQLYNKFAEAVSVSGNEERLVRVHDVIQQLPPPHYRTLEFLLRHLARMAMHSQNTSMHIRNLAIVWAPNLLRSVTLESVAQCGADAFQEVRVQSLVVEFLLNNVQTLFSDTFTSVGKDGAGRCFLPRPKSQLVSCPSTRLLSLEEAQARTQALCKITKSEARQRSADLQAQGKVSTVLSSPDTRQKAESNGRVRKTSGPGWKAFFAIGKAPVTFRKKSHRLGEIFGLGEPLPGGQPETVTLRSAKSEESLTSQASMTGLPKLPCLRRPHSSSDAFPTLKPCRSCSSLGSSVSGQGEGLAVGTVDLAARRRSSWLEGDSELDSELELSPPGLRGLDFDPLTFQCSPPAQQPSLSDESSSPSPAGPLSPCSPPTIGKDTSEPLPISLPNQVLEMFTGGETRGLNVQVSPPHMISMLLCAAGGQLNDTCEREVRCKITQTKGRSSPQSPKTEATLPSPGTLSLLQHIPPPPPPKNPARLMALALAESAHQVALQQKQQASLGQKQPRRHFRRSLSLECKAGELTSGARALYSMVRPNAKAAGPSSLQGQVRGRSRGSECHDRRGGNRMLLNHGSPVGSSDSFSPTRKVLTDMSHKDPSLHSFSDPYHLSSQPSVSPAAYSLHHQPPPVSFPYRAPRHPHDPYPLSSQSPAPPKPPPPGHFPVTPRHLPIKGRPPGSQSYLPDHRHHGRFPVSSRGGVNGTPPPQLEHENLYYEIVGEPPAYPGMARPWPTCPPPEYFATFNASYGVFERPWRQPYLPPAPPSLQTILNNPRAHSQPMPPTVTRQEPIYVNIPFPEPPSITPTPSPPPEMTHPRSHSDPGAPQPLSHHSRPPLPQKQKFGWGCPSTGQYRQLVDVLPCSRTLLQFYRPPSSCLGRPPYGPEPIITYDGPPAHLGGQASASLSSLRKLEESPPQYGNVERREGSPSGCYLGPSWTVYTEGQTHSYC
The following text describes a protein:
Function:
Essential for septate junctions. Septate junctions, which are the equivalent of vertebrate tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for formation of the hemolymph-brain barrier (the insect blood-brain barrier). Vital for embryonic development. Involved in the targeting for degradation or recycling of certain septate junction components, including kune and bou/boudin, by regulating their endocytosis; [Isoform B]: May play a role in neural and glial cell adhesion in the developing embryo; [Isoform A]: May be a more general cell adhesion molecule involved in non-neuronal tissues and imaginal disk morphogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, septate junction.
Sequence:
MWRQSTILAALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTMHRIKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVANETVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGFHEYSQPLDNKSAGRQSVSSANKPGVESDTDSMAEYGDGDTGQFTEDGSFIGQYVPGKLQPPVSPQPLNNSAAAHQAAPTAGGSGAAGSAAAAGASGGASSAGGAAASNGGAAAGAVATYV
The following text describes a protein:
Function:
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol-containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A major conformational change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host cell membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.
Subcellular Localization:
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein that then inserts into the host cell membrane and forms huge pores formed by transmembrane beta-strands.
Domain:
Mature protein has 3 discontinuous domains; D1, D2, D3 followed by C-terminal D4; the domains rearrange substantially upon membrane insertion. A highly conserved undecapeptide in the D4 domain has residues important for membrane binding and cell lysis, and penetrates into the upper leaflet of cholesterol-rich bilayers in the pre-pore complex.
Sequence:
MIRFKKTKLIASIAMALCLFSQPVISFSKDITDKNQSIDSGISSLSYNRNEVLASNGDKIESFVPKEGKKTGNKFIVVERQKRSLTTSPVDISIIDSVNDRTYPGALQLADKAFVENRPTILMVKRKPININIDLPGLKGENSIKVDDPTYGKVSGAIDELVSKWNEKYSSTHTLPARTQYSESMVYSKSQISSALNVNAKVLENSLGVDFNAVANNEKKVMILAYKQIFYTVSADLPKNPSDLFDDSVTFNDLKQKGVSNEAPPLMVSNVAYGRTIYVKLETTSSSKDVQAAFKALIKNTDIKNSQQYKDIYENSSFTAVVLGGDAQEHNKVVTKDFDEIRKVIKDNATFSTKNPAYPISYTSVFLKDNSVAAVHNKTDYIETTSTEYSKGKINLDHSGAYVAQFEVAWDEVSYDKEGNEVLTHKTWDGNYQDKTAHYSTVIPLEANARNIRIKARECTGLAWEWWRDVISEYDVPLTNNINVSIWGTTLYPGSSITYN
The following text describes a protein:
Function:
Transcriptional regulator involved in DIF-1 signaling. DIF-1 (Differentiation Inducing Factor-1) is a signal molecule involved in the differentiation of pstO (prestalk-O) cells. Functions both as an activator of prestalk gene expression and a repressor of prespore gene expression.
Subcellular Localization:
Nucleus. Note=In response to DIF-1, it accumulates rapidly in the nucleus. Nuclear accumulation is dependent on dimB.
Sequence:
MDSDNWNFQNNPYFQDYNIGNPNNNTNGINGSSNGTMNLSNSASLFLNKNLGNSDFQPFSLQPSLYLSNSSNNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNTDEFVFKKISANNLQTPTSPPKDLGFIQTILQHQQELFQKKLSESGVTNLQPDQIQFMFMQEQQKYLTSLNGNDNTLPPLENNFSFQHVNNNNLTSPPQQQQQQQQQQQQQQHQQHQQHQQHQQQQQQQQQQQQQQHQHQQQQQQQQQQQQQQQQQQQQQQLKQQQPQQHPIQSPQPIQSPTPSPSLQQHQTYSYTPSTQQTSLQQLQQQQMQQLLQMSPQHQQQHNQIQQQQAAAAAAALLQQQLAQQQAQQLAQQQQLAQQQLAQQQQQQQQQHVQSLHQAQVQQAHMSQLQQQQLAQQAFQQAQQQQFHQQNIQQHQNQNQQQLQLPQPQQQQHKSTPPTQNTPPVKSPAPQTPTLTTNGKGSKSTPPTTTTTTTTTTSSSSSSSSSSSSSKKKTSNKKTGNLQVPPTPPHHHHHHHNNHHHHHSEGFSDENDEEFIDENEDKSKNKSRSSQNIASRNYRQRKKDHISEVEFKVQQLSLENERLKQENHLLKKGDLGDVMRPDFDFQQVLLESQKLMSQLQDAVNKQDHATIENLLQLYYFASQLRTTVVEREVEKIVHPYTQARLAVMGYRSNAETSILLRPFSTNLWWPKYADEVGLTEEQRKASDILWTDHLKIDMELRTERDQLDREIKELFLKKIVSHGTKRPELLFERETLSTFNSESDYPSSPSSASNSSNSPPTSSPTIITPPDSPLTNNQNNQNNNQMINSNSNNSNNNSHHHHHHHHSHLHGHSPYPVPNGTVHPPPTTAVSEHNKPIELSELLDVTRKLEMLKKNFVKHRNLICDTDLVLSTILTPFQHAKLILRLNSVTCYDFSIVDTITGIWGSINSTLKEGSFIQNLMPDQDGKFEVLEKFKQNQLLDLKGQRPIKLESLQRTYEKLYQTVLGSESPNCQFVKQADYQHQNLLTASPNYTNSPLITSSPSQLTPNSPRPPLDISNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNTNNNNNNYNNNGNNNNGNNNNGNNNNGNNGNNGNNSNNSNNGNINSVDIQALHQQQKQNLQPQQLQQNQQLQQNQNTPPQQSQQVCSPSSPMTPELNKQPEIVGGDNTNKKNKSKKYQWYSYKTPNI
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MTPPVATDAAFSHSSNGVVLSTSVDPSGTVLVIGSMTSAQSGAYQKAVEAYSGRQVEMHMVDRLTDGATSLSANTYPLAHLAVNYAEAASPVLLSSLHSALQPKAKLIVEAAELVDASTAQKVKAELIIAGFTDIQVDVATGSVSASKPATASSSFSIGSSSGSSSALPLRRKLGSGASANAKKSLWATQPASANDLIDEASLLRDADFVATTAVKRPDCDVGAGQGKKKKACKGCTCGLRELQEEEKRTANTNIVQLDTDDMDMPNADTPATTKRTEVIETIIGKDGKPKTIKRIQVDTKGATSSCGSCFLGDAFRCSSCPYLGLPAFEPGQKVEIPVGMDDDI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSNRSITLLQRVDNATEQLNSKFTDIVNSAKVSSKDKSALAMETYLVEESTSAMVRSLEDLLFVTRSLKEAWILGQIRPVVNKPEDGGEGQLADELLDKIEDTSDGVDKETA
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MNGDMQSTEAVGCKNTSIGEYSTFERSPRMSGGGRSASEYVDLSNANIGKNLMPQKPKGSFASDMKNLIGEAICRICQESFSTTVTALTEPIDIYSEWIDECARVNNLEDDGD
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing. Required for the efficient termination by RNA polymerase I and the processing of the IST2 pre-rRNA internal transcribed spacer localized between the 5.8S and 25S rRNAs. May act by maintaining the phosphorylated status of the downstream RNT1 cleavage product, which in turn allows the torpedo activity of RAT1 to efficiently terminate Pol I transcription. In vitro, displays polynucleotide kinase activity on both single- and double-stranded RNA and on single-stranded DNA alone, but not double-stranded DNA alone.
Subcellular Localization:
Nucleus, nucleolus. Note=Associates with rDNA.
Sequence:
MVIDSKQDLPQYTKDSGSESDSDSSNNFIVESPSIPSSKSATVVLNSEEYEDDEGDDLNGLDAELIDNITYEGDEDETMFVGLKEKQKLHLSGVFRLQVVKGGIVYNNVHYNASREILTFWHPLSQSIPTIDFSHFAGWQDTFFMPRNNRFKIRDEEFKSFPCVLRVFNSNHTGLLEAGHLYRDVNYLWKPKEPYFPLNERTTYHLLHESDRIQSLSVPGYWSTPLEKLYLSHKNAAYDTRIMVIGGKNSGKSTFLRLLLEKFTQDIRDSTTSQEELVYLDLDPGQPEYSLPDSISLNKILSSPISLGQHLCQGSNFQTLLQFYAGSSSPQDEPTSYLNCADKLIDHLEEQAFFGTSLLNLPGWIKGFGMQILNHIIRKYKPTHLLFLETANSKRHLDELTIPQSFSTSLRDAYAPEVVRVPAHSLNHTLSSRFHASQLRTFKILALFHKITQFDYDFAPLLKSAPLQISYGKGKSGIKGIQFPMEFQDLNPQDIKSALEGTVIGIYTYSGEDSLEVKSLNTFPILQSCTSSSKNFITLGLIHSIDTSQQIMNIYVPPCHTQILDKQPEDAQWIIVRNKTETPFCDFLPSPRTITWDDNIQIPFATFERRKKLEHVWKVRKNVMRRGQFMKR
The following text describes a protein:
Function:
Probably an RNase.
Sequence:
MEIIFRGAALEVGRSCIEIKTDKSKILLDCGVKLGKEIEYPILDNSIRDVDKVFISHAHLDHSGALPVLFHRKMDVPVITTELSKKLIKVLLKDMVKIAETENKKIPYNNHDVKEAIRHTIPLNYNDKKYYKDFSYELFSAGHIPGSASILLNYQNNKTILYTGDVKLRDTRLTKGADLSYTKDDIDILIIESTYGNSIHPDRKAVELSFIEKIKEILFRGGVALIPVFAVDRAQEILLILNDYNIDAPIYLDGMAVEVTKLMLNYKHMLNESSQLEKALKNVKIIEKSEDRIKAIENLSKNGGIVVTTAGMLDGGPILYYLKLFMHNPKNALLLTGYQVRDSNGRHLIETGKIFIGKDEIKPNLEVCMYNFSCHAGMDELHEIIKKVNPELLIIQHGEEVQATILRNWALEHGFDAITPKLGEKIRI
The following text describes a protein:
Function:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.
Sequence:
MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLWPDFLGYPELGIGEKFLIKAISIATNTDENSVENLYKTIGDLGEVARRLKSKQQSTGILGFLGTTSKESLTVDEVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAKFLVRFVEGRLRVGIGDATVLDAMAIAFGGGQSASEIIERAYNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAERLSNPEEILKKMGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKYIEGKEFIIEGEIVAIDPESGEMRPFQELMHRKRKSDIYEAIKEYPVNVFLFDLMYYEDVDYTTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFFYRAISEGGEGVMVKAIGKDAIYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDSFESVCKVASGFSDEQLDELQKKLMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITISPLHTCCQDVVEKDAGLSIRFPRFIRWRDDKSPEDATTTDEILEMYNKQPKKKIESPAVDESV
The following text describes a protein:
Function:
Together with RGI1, RGI3, RGI4 and RGI5, acts as a receptor of RGF peptides (e.g. RGF1, GLV5/CLEL1/RGF2, GLV7/CLEL3/RGF3, GLV3/RGF4, GLV10/CLEL7/RGF5 and RGF10/CLELN), peptide hormones which maintain the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT, e.g. PLT1 and PLT2). Links RGF peptides signal with their downstream components.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSLQMPIPRKKALTVSHFSITLSLFLAFFISSTSASTNEVSALISWLHSSNSPPPSVFSGWNPSDSDPCQWPYITCSSSDNKLVTEINVVSVQLALPFPPNISSFTSLQKLVISNTNLTGAISSEIGDCSELIVIDLSSNSLVGEIPSSLGKLKNLQELCLNSNGLTGKIPPELGDCVSLKNLEIFDNYLSENLPLELGKISTLESIRAGGNSELSGKIPEEIGNCRNLKVLGLAATKISGSLPVSLGQLSKLQSLSVYSTMLSGEIPKELGNCSELINLFLYDNDLSGTLPKELGKLQNLEKMLLWQNNLHGPIPEEIGFMKSLNAIDLSMNYFSGTIPKSFGNLSNLQELMLSSNNITGSIPSILSNCTKLVQFQIDANQISGLIPPEIGLLKELNIFLGWQNKLEGNIPDELAGCQNLQALDLSQNYLTGSLPAGLFQLRNLTKLLLISNAISGVIPLEIGNCTSLVRLRLVNNRITGEIPKGIGFLQNLSFLDLSENNLSGPVPLEISNCRQLQMLNLSNNTLQGYLPLSLSSLTKLQVLDVSSNDLTGKIPDSLGHLISLNRLILSKNSFNGEIPSSLGHCTNLQLLDLSSNNISGTIPEELFDIQDLDIALNLSWNSLDGFIPERISALNRLSVLDISHNMLSGDLSALSGLENLVSLNISHNRFSGYLPDSKVFRQLIGAEMEGNNGLCSKGFRSCFVSNSSQLTTQRGVHSHRLRIAIGLLISVTAVLAVLGVLAVIRAKQMIRDDNDSETGENLWTWQFTPFQKLNFTVEHVLKCLVEGNVIGKGCSGIVYKAEMPNREVIAVKKLWPVTVPNLNEKTKSSGVRDSFSAEVKTLGSIRHKNIVRFLGCCWNKNTRLLMYDYMSNGSLGSLLHERSGVCSLGWEVRYKIILGAAQGLAYLHHDCVPPIVHRDIKANNILIGPDFEPYIGDFGLAKLVDDGDFARSSNTIAGSYGYIAPEYGYSMKITEKSDVYSYGVVVLEVLTGKQPIDPTIPDGLHIVDWVKKIRDIQVIDQGLQARPESEVEEMMQTLGVALLCINPIPEDRPTMKDVAAMLSEICQEREESMKVDGCSGSCNNGRERGKDDSTSSVMQQTAKYLRSSSTSFSASSLLYSSSSSATSNVRPNLK