lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity. Recruited to sites of DNA damage and may play a role in DNA damage repair.
Subcellular Localization:
Cell projection, stereocilium. Cell projection, microvillus. Nucleus, nucleoplasm. Cytoplasm. Note=Localized prominently at the basal taper region of hair cell stereocilia (By similarity). Forms organized ring-like structures with diameters ranging from 150 to 200 nm in the stereocilium taper region (By similarity). Detected in microvilli of inner hair cell supporting cells (By similarity). Predominantly nuclear in non-stereocilium cells but can shuttle between the nucleus and the cytoplasm.
Sequence:
MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENPFMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRAAEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAPGPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAGSPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIRPAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGPASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPPPFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPARPLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF
The following text describes a protein:
Function:
Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response. Required for normal sarcomere structure and muscle fiber integrity (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, myofibril, sarcomere.
Sequence:
MEAARPPPTAGKFVVVGGGIAGVTCAEQLATHFPSEDILLVTASPVIKAVTNFKQISKILEEFDVEEQSSTMLGKRFPNIKVIESGVKQLKSEEHCIVTEDGNQHVYKKLCLCAGAKPKLICEGNPYVLGIRDTDSAQEFQKQLTKAKRIMIIGNGGIALELVYEIEGCEVIWAIKDKAIGNTFFDAGAAEFLTSKLIAEKSEAKIAHKRTRYTTEGRKKEARSKSKADNVGSALGPDWHEGLNLKGTKEFSHKIHLETMCEVKKIYLQDEFRILKKKSFTFPRDHKSVTADTEMWPVYVELTNEKIYGCDFIVSATGVTPNVEPFLHGNSFDLGEDGGLKVDDHMHTSLPDIYAAGDICTTSWQLSPVWQQMRLWTQARQMGWYAAKCMAAASSGDSIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGSDHELMLRCTKGREYIKVVMQNGRMMGAVLIGETDLEETFENLILNQMNLSSYGEDLLDPNIDIEDYFD
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MKVVTTETPLTQGVLLAGGLARRMGGGDKPMRTIGGRTILERVIARLSPQCSGLILNANGDPARFAAFGLQVVADDVPGFPGPLAGILAALDWTAANRPGIEWVLSAAGDCPFLPRDLVARLHEARERESAQLAVAASGDQTHPVIGLWRVALRDELRHALVVEDLRKIDRWTARYPLATVTWPVEPLDPFFNANTVEDIAEAERLAALDDAA
The following text describes a protein:
Function:
Required for pre-mRNA splicing and spliceosome assembly.
Subcellular Localization:
Nucleus.
Sequence:
MNSIRQIERLNEQELDKPFSSSWHQDYSDSAYIYIGNLDFDLNEDDILCVFSEFGEPVDINLVRDKETGKSKGFAFLKYEDQRSTVLAVDNMTNVKLLDRLVRVDHVASYKVPQKEKEPANLVPLGESGSSLSVSTINTSNLPDHDYKTIIQNEVEQTLSPKDEKDLLDPMRDYIHREKRRKLKHESSDRSDKSDSNRHSRHHRRHSRSRRHRDLDG
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner. Together with cdc18, plays a role in preventing DNA rereplication and resulting genetic instability upon cell cycle-regulated phosphorylation by cdc2.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MLINEHVRERYHFLRVSLTRVAHLVFANSHESNDLKMVENVSSTPKKGVLEDPSTLTPEVVTPRTPGHRIIKAKGAYTKDRSAKRRRGRIEIERHLLGEFDDNVGSNSLLDVPLYSLEAEPLSPSVMLEDESMEGINQSPQGISVEKLGKEDNRSRSSTPASPSLESHEFSESREAGLSQSNGFEARSHGTGFDEYFDKFSQRKTSSNTLSQLPVLDNQVYLDTVKEICTETEQHTQTLVHFQSRNFHQWYFELVNNFNLLFYGFGSKEHFLSSFVEKKLPCFPIFVVKGYFPQLQLKNVLSSFLEFLEVTPAASVSDMLIQSLSIINSPSFSLGKIVFLVHNIDGESLIDERFQSALAAIASSKNVYFIASVDHVNFALLWDTSLESSFNFVMHDATTFARYYNETTYENSLGIGRANVSNKEKAIKHVLYSLPANSRGIFKFLLIHQLERMMDTQDFDARQGEKVGIEYRSFFQKCSAEFLCSNEPNFRSQLTEFFDHNIIESKRDVSNSEILWVPYPKNLLEILLEDMMEDV
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MARFGVDEAGKGPVLGSMFAAAVAGDPAAVPDGVADSKRLSADRRAELDDRVRASMRVGVAEVPVDRIDDPETDMNTLTVAAQADALGRVVADGMAGYVDAGDVNEQRFGRRVANRVAADVAVTAEHGADDEYDLVAAASIVAKVARDAHVDALAAAFDADIGSGYPSDSTTREFLAAYVREHGELPECARASWQTSRDALGAAEQSALDEF
The following text describes a protein:
Function:
Involved in determining the orientation of cell expansion, probably by playing an important role in cellulose deposition. May act by recruiting cellulose synthesizing complexes to discrete positions on the cell surface.
Miscellaneous:
MISCELLANEOUS: A partial protein missing the N-terminal signal peptide was reported to complement a yeast mutant defective in phytochelatin synthesis. It is therefore possible that COBRA binds divalent metals.
Subcellular Localization:
Lateral cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Located on the longitudinal sides of the cell rather than on the apical or basal sides.
Sequence:
MESFFSRSTSIVSKLSFLALWIVFLISSSSFTSTEAYDALDPEGNITMKWDVMSWTPDGYVAVVTMFNFQKYRHIQSPGWTLGWKWAKKEVIWSMVGAQTTEQGDCSKYKGNIPHCCKKDPTVVDLLPGTPYNQQIANCCKGGVMNSWVQDPATAASSFQISVGAAGTTNKTVRVPRNFTLMGPGPGYTCGPAKIVRPTKFVTTDTRRTTQAMMTWNITCTYSQFLAQRTPTCCVSLSSFYNETIVGCPTCACGCQNNRTESGACLDPDTPHLASVVSPPTKKGTVLPPLVQCTRHMCPIRVHWHVKQNYKEYWRVKITITNFNYRLNYTQWNLVAQHPNLDNITQIFSFNYKSLTPYAGLNDTAMLWGVKFYNDFLSEAGPLGNVQSEILFRKDQSTFTFEKGWAFPRRIYFNGDNCVMPPPDSYPFLPNGGSRSQFSFVAAVLLPLLVFFFFSA
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MHARMEQSAQLLTPTLSRPKLTTNADELPEAVVLEDEGAAMAGFVGLLRQLGDLAQLAAEVFDGLHEQATAVSARARGLTLGTRRLEAELTLVEERLRRRRSARPCFVQQQDVAVACSNSVFSSGIRSEGLCRVAGHGVHRRRASARPVNHGVIVVGGTKPRSIAEHIRRCRGPPQLSMLDKYDAGGEGACLKRYTDPSFFRAQSAKHELFLQETKPKLQSSHKCSKFKTDALLDMLRQLKYRHIIGRIRRQMHSSHNQDSPEDEASEAHVLSPSDSPETSNTKVPCPSVPVNKERSSDLVERTSSFRAWLSPDAASTHASDIIQETNADGFASHGANKADDNANIATNARSALINFIASRVESSPRKLSVRKHSDPLTESFRNMAKKVLLENESAHSSQRTSEF
The following text describes a protein:
Function:
Involved in formation and maintenance of cell shape.
Sequence:
MKPIFSRGPSLQIRLILAVLVALGVIIADSRLGTFSQIRTYMDTAVSPFYFISNGPRELLDSVSQTLASRDQLELENRALRQELLLKNSDLLMLGQYKQENARLRELLGSPLRQDEQKMVTQVISTVNDPYSDQVVIDKGSVNGVYEGQPVISDKGVVGQVVAVAKLTSRVLLICDATHALPIQVLRNDIRVIAAGNGCTDDLQLEHLPANTDIRVGDVLVTSGLGGRFPEGYPVAVVSSVKLDTQRAYTVIQARPTAGLQRLRYLLLLWGADRNGANPMTPEEVHRVANERLMQMMPQVLPSPDAMGPPAPVPDPATGITQPSAGQTAPVSTQPSPSGATTPPARAPGG
The following text describes a protein:
Function:
Acts as a negative regulator of seedling photomorphogenesis. BBX25/STH and BBX24/STO function as transcriptional corepressors of HY5 activity, leading to the down-regulation of BBX22 expression. BBX25/STH acts additively with BBX24/STO during de-etiolation and the hypocotyl shade avoidance response.
Subcellular Localization:
Nucleus.
Sequence:
MKIQCDVCEKAPATLICCADEAALCAKCDVEVHAANKLASKHQRLFLDSLSTKFPPCDICLEKAAFIFCVEDRALLCRDCDEATHAPNTRSANHQRFLATGIRVALSSTSCNQEVEKNHFDPSNQQSLSKPPTQQPAAPSPLWATDEFFSYSDLDCSNKEKEQLDLGELDWLAEMGLFGDQPDQEALPVAEVPELSFSHLAHAHSYNRPMKSNVPNKKQRLEYRYDDEEEHFLVPDLG
The following text describes a protein:
Function:
Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
Sequence:
MLDSFKEDPNLRKLLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDSVYEWLENLHNIVSLRSENELLWPSSNPPILPAEEDIPIAEYKTPDSPDRKYREHLAKGYGKKIQLLSGIHYNFSFPEALIDGLYANISLPEESKQDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFSKTKHEESLPDGSSALRDGISLRNSNAGYKNKEALFVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQTVESLAEHGVEYLEIRSIDLNPLEPNGISKDELDFIHLFLIKGLLSEDRELCANNQQLADENENNIALNGLAQPSIKNCDNEDIPLADAGLLELDKMSDFIKSLRPEDTKLRAIIEKQKERLLHPEKTIAAQVKQQVTKEGYVDFHLNQAKTYMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDVLDRAENFLRFQKGDHIEYVKQASKTSKDNYVSVLMMENKVVTKLVLAEHDIRVPFGDSFSDQALALEAFSLFEDKQIVVKPKSTNYGWGISIFKNKFTLEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELVEEKNTDPLRGTDHLKPLEKIRTGPEETLMLSMQNLSWDSIPKAEEIIYLRENSNVSTGGDSIDYTEEMDDYFKEIAIRATQVLDAKICGVDIIVPRETIDRDKHAIIELNFNPAMHMHCFPYQGEQKKIGDKILDFLFD
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MTNSSTITASTLILILLAPSMHASGTIELLVASPRTILLEPTVCANFECAAPDELSSPRKVQGELRFNTGRYQGESREIIDVHLKVIEPGTNAILAIEHHRPSADNEWNRMPIVVTTSTGFNVTVQLRNKCDSNYHGHRCGSYCIPSPDHHWECSPQGQRRCLPGWTGGDCSTPICASGCNGHGKCVAPNQCACINGYKGAQCEQCVPRAGCLNGQCHNDVPNTCKCRDGFIGDRCDIDVQVCSIEKPCANGGRCSIDTKSPNGYKCECPFDFLGPQCKTPLSSVKCSATAKDVCQNGGACISMDDRTIQCKCRAGFTGKFCEYGTHGDCSTLKCTSPTATCHMSGDLPICVESNEDVVTTTPTMKSVKVLTKKRRMEQEAAPIEQDPLLLISLLLHVNAAASTLPMTMSPTSKASTSSRPPVYKVCIIDTECGISSDQHQHHPRHHNSPPPAYTSPMMPRVYRSLPQTMDDDSNTFRSPSGKC
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MGVSKKKSGEIRGDLIPGLPEELAIECLVRVPFQFHSSIKSVCRSWKCVISSRSFIKERIGFGKAESLLCLVQPLTSPPSPAMMEGGEMSQKKKEEEEGESQMTQQLLQPRITGTPLYGLSVYNATLDTWHRVAIPERIPLFCECVAIQDAGKVLLIGGWDPETLQPVRDVFVLDFFAGEGSGRRFRRGRPMSAARSFFACASVGSTKVYVAGGHDDQKNALRSAEVYDVEKDEWSMLPPMTEGRDECHGFSMATDPGFCVLSGYGTETQGQFRSDGEIYDPITNSWSTIENVWPFPDLSPRGRTAAAAAEFPGDFRGCRLWCFIDSERQSQPHWEVEDDSMKWKVIMDTIRLPVTTMTSVFAGSLSGQAVAMIGGGGEESGTMMVKTTAEKNGGKWSHVNTPSGFSSLPFSCSSIYV
The following text describes a protein:
Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MQYAPFASDIELPFYTALATLKIDRDKLDDSARKVLGLYEVRSTDAPKNSCRMQIHGNALTSDEAEGSIKNFNTCEEYRDIDKPQMLQQAGQTILDAIEDGSIYLCPSKLSYFMILSFADLKKYKFHYWFAFPALHSTPSWTPVPYSEEIVGDTPVEPINRSPFKALSTLESSTLVEAVQTWSRSVEACQRGFFLARKYPKLDGRPEHDSKEMTKIADGTLVASSQQSAGHNWEIASLASYESGFFDGVPFEDSFICFADPSNYDDAPGWMLRNLLFLIKQRWGLRRAQILRYRDTRCENGRSMVVTMECKGQLVSRPGSFPETVSGAPKVTGWERNSAGKLSGRLVDLTEYLNPKRLADQSVDLNLKLMKWRISPDLDLEKIKRTRCLLLGAGTLGSYVARNLMAWGVTKITFVDNGNVSFSNPVRQSLFNFKDCLEGGARKATRAAQALSEIYPGVETTGHVLSVPMAGHPITDTEKTRKEFGILKALVDDHDVIFLLMDTRESRWLPTVIGKAAGKIVINAALGFDSFVVMRHGVRNDADPTSELGCYFCNDVVAPMNSVRDQTLDQQCTVTRPGVATIASALAVELLISLLQHPQGAAAPAALPGDDRGSHPLGLVPHQIRGFLSSFENISVIGRSYDCCSACSINVVNAYNEQGWEFVMKALNEPGYVEELSGLREVSRNKPLLTYPVFLVFHFPCPRQITQPQPEISGTGHKQGNFS
The following text describes a protein:
Function:
Serine protease that is responsible for cleaving many of the prohead proteins during a major morphogenetic step in viral capsid maturation. Cleaves the major capsid protein at 7 [A,G,S]-X-E recognition sites.
Subcellular Localization:
Virion. Note=Low-copy capsid protein.
Sequence:
MQPYSNFSGLQQRTNNQVVIGSDMLAGTNKKGVLVPDADGYYLTPLGAYGTRNSAGMFYEMASGVSMFNPDSPLMRRVKKGVLFMEYKHPEPYRKDGTRMNEHEYLMRIRQIDDDRVCAHIKELILVDSTDEKGLPIKLVLGKCKPYGPFGKYFEASITNPSQNTYCSVRSITQDDPMRGIKYTREISTWDMVGEGGIYGANKWNSPALENYEDQLMVITPDTLYQVQRERERQINMGFECSDITNVTDLAKSLGWDISPVKHRRPGFMR
The following text describes a protein:
Function:
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSTERGLKDSIAGTVAGAACLFTGHPFDTIRVRLQTSNTPIGIMECFRNTIKYEGFSGLYKGVTSPLFGMMFETAVLFAGYGQMKVLLQKDENTPLTVGQCAIAGGFAGVGASVVLTPVELVKCRLQVQTTGPQKYKGSLDCLVQILKEGGIRGAYRGFTPTIAREFVGNMAFFSTYETCKRYFKNKENKPNDDDELNLPALIISGGLGGMAYWTVLYPVDVAKSKIQISEGAGPSPSIVKVLKEIYSKEGVKGLFRGYTPTIIRSFPANAAMFSVYELVIKLLG
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Zona pellucida. Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MAPSRLKISCLFGHLTAFCLQLTLAFPPLHYVPPVSLKSQSSLPSVVQQPEEPVPVNTVGVLCHPDSMELSINADLFEVGAPVDVRELRLGVEHSDYCSATASSDSEYRILVGLEDCGTKHWMTEDSLVYTNLLIYTPLPALNGITRMEEAVIPIECQYKRKYSLSSSSLVPTWVPFTSTQAAVETLQFNLRLMTNDWLHERGANTFFLGEPINIEASVRVDHHMGLRLFLNSCVATLEPNIKSDPKYVFIENGCLLDSQLPGSKGHFLPRTKDNILQMTIDSFKFHNDERGQLYITCHLNAVPVDDAEAQSKACTYVNGRWRSADGNDYLCGFCQSPNEASKALSIPGVFNPRSFGKSADMEPMWRSGLKTNKVWEHEARLGPVTILPSWKSGALAAHELPPVLHKIHKTALYGSHWRSGLNTIEKSLVPEPSSSELEEDDSDDYDESDSDLAFVMKSLEIAHTNTTFPIVTYDLEPSKMNATAANPDLSDKHDPKK
The following text describes a protein:
Function:
Forms the helical nucleocapsid (NC) in a ratio of 1 N per 6 ribonucleotides, protecting the genome from nucleases (By similarity). The encapsidated genomic RNA serves as template for transcription and replication; encapsidation by N is coupled to RNA synthesis. Forms the encapsidation complex with the phosphoprotein protein P. Before encapsidation, the newly synthesized free N protein, so-called N0, is chaperoned by P (By similarity).
Subcellular Localization:
Virion. Host cytoplasm.
Domain:
Ncore is globular and carries the regions required for self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain in the C-terminus.
Sequence:
MSSVFDEYEQLLAAQTRPNGAHGGGEKGSTLKVDVPVFTLNSDDPEDRWNFAVFCLRIAVSEDANKPLRQGALISLLCSHSQVMRNHVALAGKQNEATLAVLEIDGFANGMPQFNNRSGVSEERAQRFAMIAGSLPRACSNGTPFVTAGAEDDAPEDITDTLERILSIQAQVWVTVAKAMTAYETADESETRRINKYMQQGRVQKKYILYPVCRSTIQLTIRQSLAVRIFLVSELKRGRNTAGGTSTYYNLVGDVDSYIRNTGLTAFFLTLKYGINTKTSALALSSLSGDIQKMKQLMRLYRMKGDNAPYMTLLGDSDQMSFAPAEYAQLYSFAMGMASVLDKGTGKYQFARDFMSTSFWRLGVEYAQAQGSSINEDMAAELKLTPAARRGLAAAAQRVSEETSSIDMPTQQVGVLTGLSEGGSQALQGGSNRSQGQPEAGDGETQFLDLMRAVANSMREAPNSAQGTPQSGPPPTPGPSQDNDTDWGY
The following text describes a protein:
Function:
Formins play an important role in the nucleation of actin and the formation of linear actin filaments. Important for cell migration and formation, elongation and maintenance of filopodia. Specifically controls filopodial dynamics by regulating actin turnover at the barbed ends of actin filaments.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Enriched at the tips of filopodia. The N-terminus of the protein targets the protein to the cell cortex and the FH1/FH2 region refines the localization specifically to filopodial tips.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Sequence:
MSFDLESNSSGGSTIGRNSSIRLSSGLAPSESTVSLNEIIDLDREFELLLDKLAIEDPIKRKQMQSLPDISKRTLLEQNKADIYRTVKHKGPIESFADVKSVISSINTKHVPIDIIKTLRIHLNTADRDWIQSFLDNDGVQPILNILKRLERNKNRKRKEHSILQWECTRCIAALMKIKIGMEYIASFPQTTNLMVLCLDTPLIKAKTLVLELLAAIAVTDRGHGAVLTSMIYHKEVKKEITRYFNLVQSLKIEKNAEYLTTCMSFINCIISSPSDLPSRIEIRKAFLNLKILKYIENLRADYNEDKNLLTQLDVFEEELSTDEQLNSQQGTQIGIEDLFSQISSRVTGTPSQQELITLMTHFQRMSSSNLGLGVWTLYNALANQLEDELKIHPDLDVTLVSLLFPEVKKSSSGLFGFGSKSKSPSSSPALSSMAKTELKKDNEEKQKTIEHLLKQLNKFSGGQNTERWMIEREEKNKLIAQLMAQTKNGGGGGGGGVGGDSSLSNDEALKRENQLLRMEIENIKNNPSVLLNSGNSINGDVPNLFISSPGSTLSPSPSGEPPIPSTDFGITSSSIHTSTDKLTNSTEPILGSPPPPPPPPMSGGGGPPPPPPPPGGKSNKPAKPIIKPSVKMRNFNWITIPALKVQGTFWDKLDETSFIQSLDKVELESLFSAKAPTVKVESKQLTRKVVVTVIDMKKANNCAIMLQHFKIPNEQLKKMQIMLDEKHFSQENAIYLLQFAPTKEDIEAIKEYQGDQMQLGAAEQYMLTVMDIPKLDSRLKAFIFKQKFEGLVEDLVPDIKAIKAASLELKKSKRLSDILKFILAIGNYVNGSTTRGGAFGFKVLETLPKMRDARSNDNKLSLLHFLAKTLQDRIPEIWNIGAELPHIEHASEVSLNNIISDSSEIKRSIDLIERDFVPMINDPLFAHDKHWIHKITEFQKIAKVQYQRIEKEIDEMNKAFEEITSYFGEPKSTQPDVFFSTINNFLEDLEKAYGEYQAMIRKAELENSKMEDPEKGGLQDLSSQIRSGQLFKDRRVGDSVIAQMQNVDSLRKNLKSTSTTTPNTPPTIKIELPSQSILKPSGQLKK
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MKIAIALSLLASASAFTTPMQTMPSSALRMSEPSTAEEVAEPVVVAAPVAAAAPAMSTALPFMARPVALDGSLAGDVGFDPIGFAKSSADLMNYREAEVKHARLAMLAAAGWPLSEVFDKKIAAAFGATPILDSSDRVPSLLNGGLGKISPAYWIACIGAAAAIDVLGNMKSKGADHLPGDFGLRLGYPSDSAGQQRMQLAEIKNGRLAMIAVFGFAIQEFVSKQGVVDETPLFFFPIVETMHKLQNSGYIQ
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MAISTAIQKLRDSFNSEESANESIRCISQSIASKELTILKLVEDLQPDLLNQQNTHRCKAVSTIGTILEQLGPELKGLNEKEVELVTEFFCSKLKDHHSILPAALQGLHALSTAPKLSPGLARLISQSIFQDVHCQSQLQHDRRAIYKTLKNLLAFHLKELQDLGQDFVFGLIQLADQERDPRNLLILFSIFPVVARYFRFEPFTEEFFEVFSCYFPIDFTPPANDPYAVTKEQLCDGLRQCLAGSPHFAEYCLPLLQEKLESDLVSAKVEALKTLELCCQTYQAGQLEKWVDSFWTGIRREVLINVNTDDLEHASLDALAALSRAFTTDGEFNSPAFTKLLKNVLTECQGHLCEPERRLMTPSSYILLAICSGSAPACALIVSQVIPLLMDQYRIRPQSNPRQFILNSLNKMVHAGLYGFTEENVAQSGLASLIPKLLELYLEVLKEDDAVLRNLSLQGLSHLIGTCLNHQDLEKVNGTLLDLLQKSTATDSVIAEIGHFFCKSAEKNENLFLEQVLVKLLDIAVSGSIPTDGCARTIRPGITTGSTQSFDSFRTKGRTRNIPAIAPLGIENIGRRRSSGVTPSHLCLIEKSGFQFIFRVILLDQNVGRNVFVTFSALYRKATEFINEQTEQYVSQHLARSPWTLSIMEATLGSLDATPSGHSLERLVNTLEPLTVCHPKADVRLSACRLMAALVNKLPEGHELEAILDSLRRKWQDPSTDRCNSVCLFVWITKALLMRSYSKLNQYIQELVDSLNDPTHGYQVAEGFKTILCDTEECLNFNCHANIRLMYRQRFFQEVVPRLLKLYRESESCNKAACFAAIANQLAFIPEGVLIAHITTLIPLLIQCLSTDQPAQLIISTINAFMGLMSDNVSAIEEYISSLVPRLLTLAKDGITMDVRRLALQCLSELRKAQSIVLLPLRSEVILRLVPCLSDKKRLVRREAALARQKWIMLGQPGCN
The following text describes a protein:
Function:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.
Subcellular Localization:
Nucleus.
Sequence:
MGVQGLWQLLQPVARPIKIETLEGKRLAIDSSLWLYHFQMAMRDKDGRTLSNAHILGFLWRILKLLFHGVRPVFVFDGGAPAMKRKTLSGRKARKQGAKESHARTAEKLLAAQMRQAAVKHVADSQNRASSSSAAQVSTSQDAVDLGENTVYFDDLHAANPRVLASRDLQSTAPTSSAPASRDKSSSPTKSGGRKMDWHKDPYALPALEEDLDKVAAANGRNGRRKDYRFATEDELRAVMSTIAPEDLDTNSDLFRSLPAELQYELVGDLRAQSRMTSYKRLQSMLATAPTPIDFSRAQIAGLKTRNDLTQKVLTVTDEIGNANIKVPIRVAGQRNKEYVLVRNQGAEGGFVLGVRDAGMTQDKAIDVDYEPEDIVITDDEAQRSDSDSDPEIEMDEVEIPVQPSGSQSVSRTADPELDQLQTEADPYKRKEKALELLQARAKYHAKQKSSKPGIQDDDNNQLERTLRPQQQRQQRPLFIRNRRTTAAESSNSPDQTDWIDVDADSDDDNHDFHRMPENDDDELDEDEAEDLAWAIAESQTSNNPSRAKEPSPPLRGLKLAHRSGEPISLHDAMSHRQQSTQSTQSPVSSSRAPDLHTSQTDIAAAAGAQDAESFEINEDDFEDVQPEAPSTLREVQPVVEPQPLLDAFGRDPSPADMPDRMHELAALVGRGRKFGGEFAGPPPPPRKSLAGSLRAARRSTSTTDLREQSKPMPSPDTSIKESEKETQSETPPRPPIANAGHMGPPLRSASQQRLERAAMRPKSVTPAEATARTLHEDLSPTPEEVNRQIAVDLYADEAKDDADFKVIESAPLKERSDSRRESRSAQSKTLKNATVSTLHGQAGESMVASDAAKTVDAVDSQVAQQEEPEETGVPVSLSVPEVVLNGAQGPGITKDGADVEAKTMDNVPSASTEHTVEPTSIETAPIEGIEKRSSRQQTPIGWSPTPSPEPEAVVIGADGFPLPTAEELDALDAEDQDEIARLNADQNEFVAFLSATKGRSLLDVQKEVASEVNALRAEFANSRRSEEDITKQMAQEIQMMLRLFGLPYITAPMEAEAQCAELVSRRLVDGIITDDSDVFLFGGTRVYKNMFNNNKIVECFLLSDMQRELGLDREKLVQLAYYLGSDYTEGLVGVGPVVAMELLALFPGQDGLLKFRDWWMRVQMGQDTEEHTRGKTMRRIKRNLHNKVHLEPSWPEHAVLDAYFAPTVDESDEPFAWGLPDLDSLRTFLGEYLHWPVTKTDQYLLPIIERQNTRNRARGNQTTLDRNAFFDASSGTGVYAGRKTVTYASNRLQEVINGFRAANKARKGGGGEAERRRARGGNSSSSSSSDGEDEFQVVDARMQTPVVAEEMLGKQMGRTRRIVRRDEGTEANGGARMKDAQTSEARQAELDAAIEALENATGAQGSTSSASSASKRKKKRTKQAKGQTDADAQDGVCGSACSASSADEAVVVAKTARWTRGRRGRSTAARARSMTGRGSKARANLNAARNMSLDDVHSLPPSRSASLDPAVLRARSTTRSRSASSNASAHQ
The following text describes a protein:
Function:
Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100.
Sequence:
MGCTVSRRRTTTAEASSAWGIFGFYRPRSPSPPPQRLSLPLTVMDCPICLDVAATEAQTLPCMHKFCLDCIQRWTLTSTACPLCNARVTSILHHVDSDASFVETPVEGATDVDGEEDEPVGGGFAVIWGEDYTEEVRHEEAEGQGSGSGSRARPRVPVFNWLYGQVSTVIESDPIREAVVDNIVEIIQEHGMNRQRVTEAMLPMFGANTHALVDTLFDISAQWMRRMQRRAPMSHQGVNYIDTSESEAHSDSEVSSPDEEDSGASSSGVHTEDLTEASESADDQRPAPRRSPRRARRAAVLRREQRRTRCLRRGRTGGQAQGETPEAPSSGEGSSAQHGASGAGAGPGSANTAASARSSPSSSPSSSMRRPSPSASAPETAAPRGGPPASSSSGSPRSATIFIDLTQDDD
The following text describes a protein:
Function:
Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has probably a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of the other Ala-X dipeptides L-Ala-L-Asp, L-Ala-L-Leu, L-Ala-L-Met, and L-Ala-L-Ser. Is not able to epimerize other L-Ala-X dipeptides. Is also active with L-Ser-L-Glu and, oddly, L-Pro-L-Glu, but not with L-Glu-L-Glu, L-Lys-L-Glu, L-Lys-L-Ala, or D-Ala-D-Ala.
Sequence:
MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVGWGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAAVEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLKIKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELVEQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGISGAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFNGGITYSGSTISMPGKPGLGIIGAALLKGEKEQ