lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MDPELLRQQKAFQKHAATTVAVQNKPSAAASSHTTYSSEAAKAKKKKASGPSQNLSKLPDFDNFASNSNAISNATNFSTMAKIVDYMKKRHLSQQQWPLTLKEVLDELQLYDLGKRNIAFLQEALPNNPRLMMEPNPDGDPTMNKFAFRPPYKIKGKTSLVAVARKHYQDGKGGILVSDLAECVANYDALLQQVAADIIVVPTQVNKKKDRVVFYNDKDFTFPELEDDFKALWRNVSVDHLDEKKIEEYLQKKGLDAMKDLTPKVRMQAPLKRKAAKRRHNQKVQNDHMEGVLEDYE
The following text describes a protein:
Function:
Involved in protein export.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKGKTQKPGQTAEVRAKSREKLRFLAEMEPKKMITYPLVVFIVALLLLAVHFPPLGIDLKGGVVVTGEGISANPDQLEKELSGWLGIEAHVESFTSVSGSKGIRVYAPAGTDPQKIIDILKEKYPNADFTHSDVQPTFGEMAKKQGTRAIIFAFIAMAIVVFLFFRNPVSSLAIIFSALSDMIIAVAVMGIFGIQLTTATIAALLMLIGYTVDSNILLTTKLTKRKEYTIEEAYLSAVSTGFTMSTTTLGALLMLWIISTSPVLDNIAAVLIFGLLADFMNTWIFNAGVLRWYLSRGVEL
The following text describes a protein:
Function:
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis (By similarity).
Sequence:
MEPSTSTRKHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGLNGEVKISDFGWSVHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKPPFESSTSSETYRRIRQVDFKFPSSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWVREHSRRVLPC
The following text describes a protein:
Function:
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Sequence:
MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQDPSTNQTWLLVTSPRTKRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHHGVLICIQVLVRRPHSLSSELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCYSNKEGGGEDDVNTARQRRALEKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDFQRAKDFISNMMRNFYEKCFECNFALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVGSVTKTASAMQHVLDSIFTSSHGSRRKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGVERFAIGVGEEFKSARTARELNLIASDPDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDALHYQLAQIGFSAQILDERQVLLGAVGAFDWSGGALLYDTRSRRGRFLNQTAAAAADAEAAQYSYLGYAVAVLHKTCSLSYIAGAPRYKHHGAVFELQKEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYHVHGEEGRVYVYRLSEQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTVAPGLQYFGMSMAGGFDISGDGLADITVGTLGQAVVFRSRPVVRLKVSMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSGSQLCEDLLLMPTEGELCEEDCFSNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVSQQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIMNCRIGHPVLKRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQFRHGFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVVAVKKLTRTQASTVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEELLKDVTELQILGEISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLIVILVILFKCGFFKRKYQQLNLESIRKAQLKSENLLEEEN
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNPLIEQVFYVYFFISLTILSIAVIASKNIIHSAFFLLIFLLHVAAIFLFLNAEFLMIIQIIVYVGGVLALFIFAIMIMNIKEEFRHKRFVKFSIAGLITGFLFLAGLYIFLGTVKSPENVLIKSDVNSLGKLLYSYYFLPFEILSLVLLIAMVGGIIIAKKTPFDREGK
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Cytoplasm, Stress granule. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cell projection, dendrite. Note=Shuttles between the nucleus and the cytoplasm in a xpo1/crm1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (By similarity). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity).
Sequence:
MADRRRRRRRAFQDSEEEEDEESGSESAGSGGQPAAPSRQESREPGTKRAEPPREGKESECESEDGIEGDAVLSDYESAESEEEEAHLSEEEPLKTTLKQENNVEEAPATREQKPKSKGAVTGERQSGDGQESTEPEENKTSKKSQKQLDDDEDRKNPAYIPRKGLFFEHDLRGHVNDEEVRPKGRHPRKLWKDEGRWEHDRFREDEQAPKSREELISIYGYDIRSSKNSEEIRPRRPRKPRFGSPTRREEISEKPSRPSNRYQDSGISQPLRPYTNRNAPPSNKVGPSRTYSRQGGYKENRSSYQSEEEAPPHPSERRQDYGGHRARSTEQGPAPPREFSPEADPIIKEEPVIEKQAAEPSPPPPDRPVEKKSYSRVRRSRIKVGDTGKSMEDTTVTELPPPPPVPPAVAAEFTPAPLNVKQGNWEPPSEGGMSGIEEELSQMNLSEQSWNPGQPAYISPRGIPNPMHMGGGPPQYNRMEGMAVQGGRVKRYSTQRQRPVPDPAAMHISLMESHYYDPLQFQGPIYAHGDSPSSMPPQGMIVQPEMHLSHPGIHPHQPPATISTPNLYPAPVSLPPGQPPPQQLLPPPYFTAPPNVMNFGNPTYPYPPGALPPPPAHLYPNAQAQSQVYGGVTYYNPVQQQVQPKPSPPRRTSQPVTIKPPPPEENRHVKMKEKSNS
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPAARVEYIAPWWVVWLHSVPHLGLRLQPVDSTFRPRDESYQESLLFLGLVAAVGLGLNLVLLAAYLVCVCCCRQDDAVQTKRPRSCCVTWTAVVAALICCAAVGVGFYGNSEANDGVYQLLYALDNANHTFSGIDVLVSGTTQKMKVDLEQHLARLGEIFATRGDYLQTLKFLQQTAGSIIAQIAGVPVWTEVTEELTELANQTSSVEYYRWLSYLLLFVLDLVLCLLACLGLAKRSRCLLASMLCCGVLALLFSWTSLAADAAAAVGTSDFCAAPDTFILNITEGQVRPEVTQYYLYCSQSASSPFQQALTVFQRSLTAMQIQVAGLLQFAVPRFPTAEKDLLGIQLLLNSSESGLHQLTALLDCRGLHKDYLDALAGICYDGLEGLLYLGLFSLLAALAFSIMICLGPGAWKHCATRDRDYDDIDDDDPFNPQARRIATHNPPRGQLRSFCSYSSGLGSQGSLHPAQTISNAPVSEYMNQAALFGGNPRYENVPLIGRGSPPPTYSPSMRATYLSVADEHLRHYGNEFPG
The following text describes a protein:
Function:
Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MMDPCSVGVQLRTTNECHKTYYTRHTGFKTLQELSSNDMLLLQLRTGMTLSGNNTICFHHVKIYIDRFEDLQKSCCDPFNIHKKLAKKNLHVIDLDDATFLSAKFGRQLVPGWKLCPKCTQIINGSVDVDTEDRQKRKPESDGRTAKALRSLQFTNPGRQTEFAPETGKREKRRLTKNATAGSDRQVIPAKSKVYDSQGLLIFSGMDLCDCLDEDCLGCFYACPACGSTKCGAECRCDRKWLYEQIEIEGGEIIHNKHAG
The following text describes a protein:
Function:
Functions as an osmosensor histidine kinase that detects water stress and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. Positive regulator of drought and salt stress responses, and abscisic acid (ABA) signaling. Confers drought tolerance, probably by regulating levels of ABA accumulation. Plays a redundant role in regulating plant growth and development. Required for the regulation of desiccation processes during seed formation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRGDSFSMSIENLPDSPMGSRKKKMQIRKVFDKMTEWVTPWRSNLESPREMMILRGDVEQDEFQYASSHCLSSYYSVFVVRLAIMVMLAILIGLLTVLTWHFTRIYTKQSLQTLAYGLRYELLQRPVLRMWSVLNTTSELTTAQVKLSEYVIKKYDKPTTQEELVEMYQAMKDVTWALFASAKALNAITINYRNGFVQAFHRDPASSSTFYIFSDLKNYSISGTGPEDVSGWNNKSIHGNMSAIWYQQQLDPVTGENLGKPLKIPPDDLINIAGISQVPDGEASWHVTVSKYMDSPLLSAALPVFDASNKSIVAVVGVTTALYSVGQLMRDLVEVHGGHIYLTSQEGYLLATSTDGPLLKNTSNGPQLMKATDSEEWVIKSGAQWLEKTYGSKRPHVVHAENVKLGDQRYYIDSFYLNLKRLPIVGVVIIPRKFIMGKVDERAFKTLIILISASVCIFFIGCVCILILTNGVSKEMKLRAELIRQLDARRRAEASSNYKSQFLANMSHELRTPMAAVIGLLDILISDDCLSNEQYATVTQIRKCSTALLRLLNNILDLSKVESGKLVLEEAEFDLGRELEGLVDMFSVQCINHNVETVLDLSDDMPALVRGDSARLVQIFANLISNSIKFTTTGHIILRGWCENINSLHDEMSVSVDRRKPWAPMKTKQVQHRNHLQKSCKNANKMVLWFEVDDTGCGIDPSKWDSVFESFEQADPSTTRTHGGTGLGLCIVRNLVNKMGGEIKVVQKNGLGTLMRLYLILSTPDTVDQNIQPDFSKYGLVVMLSMYGSTARMITSKWLRKHGIATVEASDWNELTQIIRDLLETGSRDNSFDSQHNISDPLRAELSNIVEIKNPVFVIVVDIGVLDLTTNIWKEQLNYLDRFSNKAKFAWLLKHDTSNTVKTELRRKGHVMMVNKPLYKAKMIQILEAVIKNRKRGLCNDLRNRGNGSDESHDCLEIDPTQFDTCSSDDSSETSGEKQVDKSVKPSTLHSPVLKNYLIDATTSNDDSTSASMTQKNPEEEDWKDRLYSGIALDGKNQKSLEGIRILLAEDTPVLQRVATIMLEKMGATVTAVWDGQQAVDSLNYKSINAQAPTEEHKSFEEETANKVTTRETSLRNSSPYDLILMDCQMPKMDGYEATKAIRRAEIGTELHIPIVALTAHAMSSDEAKCLEVGMDAYLTKPIDRKLMVSTILSLTKPSAFQTSLSA
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MASELEPEVQAIDRSLLECSAEETAGKWLQATDLTREVYQHLAHYVPKIYCRGPNPAPQREDMLAQHVLLGPMEWYLCGEDPAFGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHREHRYRMTTSGGGGFCDCGDTEAWKEGPYCTKHDLNTSETEEEEDPLVHLTEDMIARTYNIFAIMFRYAVDILTWEKENELPPDLEIVGKSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTKPLKVQVMHSSIVAHQSFGLKLLTWLGSIIGYSDGLRRILCQVGLQEGPDGENSSLVDKLMLCDSKLWKDIFNGFIDYVTDDHDREFSIADLSVQIFTVPSLARMLITEENLMTTIIKTFMDHLKHRDIQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTDWSEDLRHKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMMQDWCALDEKVLIEAYRKCLAVLMQCHSGFTDGEQPITLSLCGHAVDTIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDIVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSENTNKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGHVNATDEIKREIIHQLSIRPMAHSELVKALPEDENKETGMETVIEAVACFKKPGLTGRGLYELKPECTKDFNLYFYHFSRAEQSKVIGGEGEGILVNILQSDVMLCIMGTILQWAVEHNGYAWSESMLQRVLHLIGMALQEEKQHLENVSEEPVVTFTFTQKISRPGDTSSNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAIKKIRESSSTSPVAEAEGTIMEENSKDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSTILDNSPMISDTPLIALGPEQTQVTEQRQIVTCILCQEEQEVKVDNKAMVLAAFVQRSTVLSKNRNKFIQDPEKYDPLFMHPDLSCGTHTGSCGHIMHAHCWQRYFDAVQAKEQRRQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLLPPRNIFNRLDFSDQPNLVQWIRTVTQQIKALQVLRKEESTFNPPSSENSESMIELQFPEGFRPDFRPKNPYSESIKEMLTTFGTATYKVGLKVHPNEEDPRVPIMCWGSCAYTIQTIERILNDEEKPLFGHLPCRQDDCLKSLTRFAAAHWTAASFPVVQEHFCILFASLVPNEKYGNLPCILDIDMFHLLVSLVLSFPALQCQDFSGFSLTTGDLHIFHLVTMAHIVQILLTSCTEENGMDQENPTGEEELAVLALYKTLCHWSMFALKEIPSGWHLWRSVKAGIMPFLRCSALFFHYLNGVPAPSEIQVIGANQFEHLCSYLSLPNNLICLFQENSKIMNTLIESWCNNSEVKKYLEGGRQAISYARESNKLIDLPDDYSIFCPVTILRDKSRAPTLCLVCGTMLCSQSYCCQTELEGEDVGACTAHTYTCGSGVGIFLRVRECQVLFLAGKTKGCFYAPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLWQQHSITEEIGHAQEANQTLVGIDWQHL
The following text describes a protein:
Function:
Enhances NF-kappa-B, SRF and AP1 transactivation (By similarity). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQQQQQPKVKLSKKDYIEKKEKEQQLLNNNNKVNREKDGKIMIEKNLQEKQDDILMNEKKKQQSGLGIDKTFTLVINTLGHLEKKNDLDQYWVLNNKEYHLSFITFLPADNNEQGSSEESILFMNSDLSSLLKFQYNIFWSHCIFNKSLNEFIDSFLKFFKRDNQPIISLVNNNSVNNNNNNNNSIIKKGSKDFNESKKLLFKRVFLVLVRMSLQQEKSGFITREFYSDLIYKNKLFTIPKLFDIVSLYSSHARDAVTTMIQSIFDTQPNYYKDLLQHFQLISKTLFELNQSLLNRNLLDLLRLEDNYLMDIVYNLEQFIRIFPMGSHQLFDEYLMNLEKGGGDGNGGVLGWLTYFYEYIIPIFNKENQKASNKQVNLTPSIYVPLKQHILSIFHTIFRHHFMIKLEQLQLLIQDPCQLCKKLPLDEISHRFFSLLGNITSFSQQIIGSTKSNRSKLFNEYFDNITSASILYDYEQTYKLSNFLDKLVTLDSSIDFTSYTYFMQLIGKPVSQDQKQIQKPKFKKSTTIIDSNISSSSSSSSSSSPSNATTTVKPILSNNPVIMNTVKIDQVKSLFPDLGDWFVHCCLKYYNQDVEQVINALCDDSSLPPHLKSMDRSLSSDPSQPSKNIPTPTTTTTTTTTTDKPNNTTTATTTTTTTTSSSKSLEKSMNELNISIGYEKIYDEKYDDSLEEFSGFSVQDGEKYNDEDEDEKKDSENNTNTEDQKHPTTSASGRTPNESNNLGRPRQNNPNKGRKEDNRNNKQQTHSSHHSQPQQQQQQQPPQHQPQPHQQPQQQPQPHQHQQPQQQQPQQPQHKQQPKPQQSKQHPQQQPKQQPKQQPQQPKQQSQQQPKQHPQPQQPQQPQPQPQPQPQQQQQQQQQQQQQQQQRQPQQPQQPQPQQQNQQQNQQQNQQPKKSQNDDKPKPDKKPKGSYSKGGSVGGGR
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MATLVAPQAGGSTGGKPKEKKSQEEIAAEFQQLRNQQRNLVNNLNTIEMDLKEHKTVIDTLKTVESSRKCFRLIGGVLVEQTVEVVLPQLELNKAQLEKLIEEGKEQITKKGLEINQFKDEHNIKVRGQEPSQPAGSEKEENAADEKSSGNRNVLVGNL
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLRRVAPPLRRALASSAVQHRGGARLPDPGLSSPHALPPQWRRWASAAAASSLPPPPPSPPRGPPRHAGGGSAASSLNPAEVAKFAAIAETWWDAQGPFKPLHLMNPTRLSFIRSTLCRHFRRDPYSAKPLEGLKVIDVGCGGGILSEPLARMGATVTGIDAVDKNIKIAHIHAASDPTTASIEYCCTTAEDLVKENKQFDAVISLEVIEHVANPLEFCQSLSALTVPNGATVISTINRSMRAYAAAIVGAEYILRWLPIGTHEWSKLVTPEELVLALQRASISVEEMAGFFYNPLTREWSVSDDISINYIAYGIKKSEAPSATPQ
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adaptor. Facilitates interaction between APL1 and APS2.
Miscellaneous:
MISCELLANEOUS: Present with 1590 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Sequence:
MDRKKTLINSSVSNNNSTIKGLQLFIADLRSAQQAQEQEKRIQSEIVKIKQHFDAAKKKQGNHDRLGGYQRKKYVAKLAYIYITSNTTKLNEILFGLEQTVELLKSSIFSEKFIGYMTLELLYERSEVVAKVNDEVNYQLMKDLSSSDDNFVMLALNFVGVVGELTNRLAYNDDITTGVFKILRSPTSSIYLKKKSALSFLALLKSNHSILTEDLQRKQLWIQRILSLLDDTENYRLTLATIPLIEFIAKYIDPSYCTRLLPQLTEILYNCVVVGTSRSSDNQFPLEYTFANMPNPWLITKVVSLLSILIASPTERDSGSLLQTNNIDNELLNKLRKCVSVAIELGTRQAQDPMERIVQNTVLFSLINFASKLDPSDEAISNSVTALCSLLTSKEINIRYLTLDSLVKLCSSSGKPAIDAVRYKNLDMIFHLLNTERDSSIVRKVVDLLYTFTDVENVKIIVDGLLQYILSPKNLAEPQIKSDIAVKIAILTEKYATDINWFVIISLQLLSLTSNTTINDDEIWQRLCQIVVNNPSLHRITCERLVDYLCKKQASEAIIKAAAFLLGEYSSLITDRISSANLFTLFAEKYFSAPNVAKAMILTTMIKLYKTSPEIGSNVIKFFQLELNSLDIELQTRSFEYLNIIQLAKVNGNTDILQILFEPMPPFNSKSNPLLKRLGSLPASAGSTTLINTPSEASSSTPDLLSKRANSSRSIMVPMPPPSRRNTIDDVNSKISSSEDFSGKDSYYSRQILAPNWREGFTRMISHKQGVLFTSSLMKVFYRITTPDAQQPYVFHISLAFINLTEWEITGLSTQIIPSKTQGNPEYLIMNINTPSTATIGPHKRAEQSYEVSIRKPFDVEDSPILAIHFKCGGSTNTINLKTAIGMTTTLISSDVNPSMHLNLAQFISRWKTLSDALGKEGEYQKSGIKLNKDFRKVETISLEDGLLLLTQTVKRLGFDIVDQTSVRSTLFVSGIIHTKSEGNFGCLMKIQYQVNGTVNVTCKTTTAGPLAKYIVECIKNVLTK
The following text describes a protein:
Function:
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSIIGSFPPGGPRVEVQETRVQTDRVLTIPNILSMARLAGVPLFLWLILRPEFGGPQSDGWALLVLALSGVSDYLDGKLARRWNQISSLGRLLDPAADRLYILSTLVGLTWREILPLWLTLVLLAREAMLLVMVGILRRHGYPPPQVNFLGKAATFNLMYAFPLLLLSDGSGWIASLAAVFGWAFAGWGTTLYWWAGVLYVVQVRRLVRADVAAD
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRGKIVIRRIDNSTSRQVTFSKRRNGLLKKAKELAILCDAEVGVIIFSSTGRLYEYSSTSMKSVIERYNKTKEENHQLATPTSEVRFWQREAAVLRQQLQNLQENHRLRAPRLIPRDTCHLPPATDTRQMMGEELSGLSVKDLQNLENQLEMSLRGVRVRKDEILIDEIQELNRKGNLIHQENMELYKKVYGNRDANGVSGIALAPNSLSINEDPHTPVHLQLSQPQQQNYGTSGTTELGLQLH
The following text describes a protein:
Function:
Has a role in de-ubiquitination. In conjunction with UBP3, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of sec23.
Miscellaneous:
MISCELLANEOUS: Present with 11700 molecules/cell in log phase SD medium.
Sequence:
MGVTVQDICFAFLQNYYERMRTDPSKLAYFYASTAELTHTNYQSKSTNEKDDVLPTVKVTGRENINKFFSRNDAKVRSLKLKLDTIDFQYTGHLHKSILIMATGEMFWTGTPVYKFCQTFILLPSSNGSTFDITNDIIRFISNSFKPYVLTDASLSQSNEENSVSAVEEDKIRHESGVEKEKEKEKSPEISKPKAKKETVKDTTAPTESSTQEKPIVDHSQPRAIPVTKESKIHTETVPSSTKGNHKQDEVSTEELGNVTKLNEKSHKAEKKAAPIKTKEGSVEAINAVNNSSLPNGKEVSDEKPVPGGVKEAETEIKPIEPQVSDAKESGNNASTPSSSPEPVANPPKMTWASKLMNENSDRISKNNTTVEYIRPETLPKKPTERKFEMGNRRDNASANSKNKKKPVFSTVNKDGFYPIYIRGTNGLREEKLRSALEKEFGKVMRITAADNFAVVDFETQKSQIDALEKKKKSIDGIEVCLERKTVKKPTSNNPPGIFTNGTRSHRKQPLKRKD
The following text describes a protein:
Function:
Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels. Is involved in adipocyte differentiation. Also acts as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression; [Isoform 1]: Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.
Subcellular Localization:
[Isoform 1]: Mitochondrion outer membrane. Cytoplasm. Nucleus membrane. Note=Recruited at the mitochondrion outer membrane following phosphatidic acid formation mediated by PLD6. In neuronals cells, isoform 1 is exclusively cytoplasmic. In 3T3-L1 pre-adipocytes, it primarily located in the cytoplasm; [Isoform 2]: Nucleus. Cytoplasm. Endoplasmic reticulum membrane. Note=Nuclear localization requires both CNEP1R1 and CTDNEP1. In neuronals cells, localized in both the cytoplasm and the nucleus. In 3T3-L1 pre-adipocytes, it is predominantly nuclear. Translocates from the cytosol to the endoplasmic reticulum following acetylation by KAT5 (By similarity).
Domain:
Contains one Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity; Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA.
Sequence:
MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEIIPMYLATSPILSEGAARMESQLKRNSVDRIRCLDPTTAAQGLPPSDTPSTGSLGKKRRKRRRKAQLDNLKRDDNVNSSEDEDMFPIEMSSDEDTAPMDGSRTLPNDVPPFQDDIPKENFPSISTHPQSASYPSSDREWSPSPSSLVDCQRTPPHLAEGVLSSSCPLQSCHFHASESPSGSRPSTPKSDSELVSKSADRLTPKNNLEMLWLWGELPQAAKSSSPHKMKESSPLGSRKTPDKMNFQAIHSESSDTFSDQSPTMARGLLIHQSKAQTEMQFVNEEDLESLGAAAPPSPVAEELKAPYPNTAQSSSKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPGGLPKQASDNGARSANQSPQSVGGSGIDSGVESTSDSLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFADNPAIIDDPNLVVKVGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNATIKEESKPEQCLTGKGHNTGEQPAQLGLATRIKHESSSSDEEHAAAKPSGSSHLSLLSNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSCDFPCSDTFSNFTFWREPLPPFENQDMHSASA
The following text describes a protein:
Function:
May play roles in cilia formation and/or maintenance.
Sequence:
MQGSPRRLSAVNFLSTFFQGRRHSTSDPLLRLYQRRRNSVIEVLSSSSHRVMVAVSSVSNAEINPTFPERKRSSRRPTPKYTKVGERLRHVIPGHVACSMACGGRACKYENPARWSDQEQAIKGIYSSWVTDNILAMARPSTELIEKYNIIEQFQSYGIKTIINLQRPGEHASCGNTLEPESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLIPLRNVFSCCEPKAHAVTLSQYLIRQRHLLHGYEARLLKHVPKIVHLVCKLLLDLAENRQVIKEDIIKVPDLSAEIEKTVSEMVTMQLDKEFMKQENDTSLTFTPSAVTVAFENQEAFLSSEHEFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAEFLLEQGETPWTVPPQTLACCNPKQEQTVSRPCVEPSPPLDISKDALVRNTFSFWNQPKCSLEGSREEGSPLFHRRKIPKEVQRSRTFSSGFSGVHHTGESVTPKAAITPMLPNSLPQKADPCQYNPGGPWGQDPVACAGSYYVPQNCGATLEGECIVTSESQESHNPPQAMPLSPEGRRVLAAKALANLNEFIEEAEVKQKVEMWQKELNSRDGAWERIYGERDPFILCGLMWSWVEQLKEPVITKEDIDMLVSNYADDSEALSLLEKEQHQTILCILHCIVNLQTIPVDVEEAFLAHAIKSFTKERWFTQGIRGGKNYLYKLHNNFFTETIPTQESQNFRCWKASQWSSNSIYV
The following text describes a protein:
Function:
Needed for flagellar regrowth and assembly.
Subcellular Localization:
Cytoplasm.
Sequence:
MKFFSLIYKDQEVVPNKKVLSPDAYTAVLTAQELLEKTQEDCEAYTQNTHEECAKLREEAKNQGFQEGSKAWSKQLAFLITETQAMREQIKASLVPLAIASIKKIIGKELETKPETVVSIISESLKDLTQNKRIVIHINPQDLAIVEQHRPELKKLVEYADVLLLSPKASVSPGGCIIETETGIVNAQLDVQLAALEQAFSAILKHKKPADASTIDQPQSKKD
The following text describes a protein:
Function:
Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Sequence:
LASSKHFLFLSLRHFIYFSFPAVILKKKEVFVKVVDLLSTGEAYLNENAVHSFLNILKKRVQCSDVSCEKTCLLGVTIGELILNFIYCIVIVNNHMKCTSRLDSEGFFKVAPGLCFYMSDPAEACAAVKENQWQRETEAFVQGIKAKGNQGDGFDLSPVELDHMLHKIERHCLAMGKDQDCFTGRLILKESNVSSTDKFLHGIETVFGSIVYHKLRGDCMSVRVLPEAQYFLDYIFHHFQNGSDIMTLEDLTHLMLELDLGISRNGNGDHEHQLKQSRSEVHQYLVWLFLQNDSFSFFLNRTFLKMCFSAKEILEIYHVNSSSEISAAQFTQLSPALIQQLLSQACTQIPDHSNANGDLSVIERYIYASIATLVICLFALFGIVVLLCSSCSQAYQHIIQFCISLAVGSLTGDAILHLMPQILGLHVHSDGEHHDSGDSTNYIWKLVLLLGGIYFFFLMETLFSIMIQEDTQQSVCVVHHEGLDTHHCDHGTVLQVYHNERKSHQSSSQADLVKQEKTEKSILATEYSSRENRLLPYMITIGDGIHNFADGLAIGAAFSVSWKSGLATSLAVLCHEIPHELGDFAVLLHCGVSVKRALLLNLGSALTSFIGLYIALSVATNPSAKDWISAFTAGLFLYVALADMLPTMMHVKSRSPLFVFFLHNLGLMVGWGILLLLSFYEDNIGF
The following text describes a protein:
Function:
Involved in mitochondria homeostasis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVIILFIRRRLATNPLSTQMCIAGTISGSGDCLAQYLSHNQEWDRWRTARFSFLSSCFMAPSLFIWFRLLEKVKGNNKSLLLVKKLCIDQLCFSPCFNAAILFNLRLLQHQSAEKSWDLLKEDWFNIYATSLKVWPFVQVVNLCFVPLNYRVILNQVVAFFWNCYLSYITQKPIDHIEQFY