lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Directly activates the transcription of SsrB. Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SsaR (SpiR) and Pir at transcriptional and post-transcriptional levels respectively. Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene. Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells. Negatively regulates prgH, which is required for invasion of epithelial cells. PhoP uses multiple mechanisms to promote transcription and activates promoters for PAG at low (uM range) Mg(2+) concentrations (Probable). Involved in acid tolerance.
Miscellaneous:
MISCELLANEOUS: PhoP/PhoQ-signaling cascade, which activates virulence membrane proteins (PagC, PagO, PagD, PagK, PgtE and PhoN), is induced by cationic antimicrobial peptides (CAMP) (polymyxin, alpha-helical peptide C18G and sheet peptide protegrin-1) at sublethal concentrations.
Subcellular Localization:
Cytoplasm.
Sequence:
MMRVLVVEDNALLRHHLKVQLQDSGHQVDAAEDAREADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSSDVSLPVLVLTAREGWQDKVEVLSSGADDYVTKPFHIEEVMARMQALMRRNSGLASQVINIPPFQVDLSRRELSVNEEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPHDVITTVRGQGYLFELR
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MELYKCENCTFVTKLPFNTTNHLTIHAKGSETFDCSSDLEPYKCHKCQTFETPLLSQMRHHNLQGHTSQSVKLTINKCPSCDFTSFSRYLFARHLITSNHQKKEVYWCKNCNFTTNFPYNLKRHVILRHTDDSQIHWFKCKHCQFKAKNKDNLRKHLINRHEAKNVNPAQLLVCDHCDYKCTKKYRLKEHKLAMHSLLCDFEYFPCDQCQFKTLFKSTLNKHVTVTHGSDWFKCDQCKFETKYKQNLQNHLLTKHNHNPKLFECDKCGHKTKTKATLIKHRKHKHENTPLFHCDICDYTTNVNRNLIKHCDARHATGYHKCNKCDLSFETRFELTTHTKNEHFKVIVKYQCHLCDFKTNSKLELATHKKTEHLKNVKLYECQLCDFKSEHKGNFGNHKLQKHSDKWLKCEQCGYQTKWKSSLLRHVRTQHG
The following text describes a protein:
Function:
Baseplate protein that is located next to the tail tube (inner baseplate). Involved in the tail assembly. The gp25-(gp6)2-gp7 module is involved in sheath contraction.
Subcellular Localization:
Virion. Note=12 copies of gp6 form a continuous ring that makes up most of the inner baseplate.
Sequence:
MANTPVNYQLTRTANAIPEIFVGGTFAEIKQNLIEWLNGQNEFLDYDFEGSRLNVLCDLLAYNTLYIQQFGNAAVYESFMRTANLRSSVVQAAQDNGYLPTSKSAAQTEIMLTCTDALNRNYITIPRGTRFLAYAKDTSVNPYNFVSREDVIAIRDKNNQYFPRLKLAQGRIVRTEIIYDKLTPIIIYDKNIDRNQVKLYVDGAEWINWTRKSMVHAGSTSTIYYMRETIDGNTEFYFGEGEISVNASEGALTANYIGGLKPTQNSTIVIEYISTNGADANGAVGFSYADTLTNITVININENPNDDPDFVGADGGGDPEDIERIRELGTIKRETQQRCVTATDYDTFVSERFGSIIQAVQTFTDSTKPGYAFIAAKPKSGLYLTTVQREDIKNYLKDYNLAPITPSIISPNYLFIKTNLKVTYALNKLQESEQWLEGQIIDKIDRYYTEDVEIFNSSFAKSKMLTYVDDADHSVIGSSATIQMVREVQNFYKTPEAGIKYNNQIKDRSMESNTFSFNSGRKVVNPDTGLEEDVLYDVRIVSTDRDSKGIGKVIIGPFASGDVTENENIQPYTGNDFNKLANSDGRDKYYVIGEINYPADVIYWNIAKINLTSEKFEVQTIELYSDPTDDVIFTRDGSLIVFENDLRPQYLTIDLEPISQ
The following text describes a protein:
Function:
May regulate transcription elongation by RNA polymerase II. May enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex.
Subcellular Localization:
Nucleus.
Sequence:
MGEVAAQIPTSFGHELRACLRCRLVKTYDQFRDSGCENCPFFKIEEDPERIVDVTTPNFNGTISMMDPRRSWAARWLRIGKFAPGCYALAVSETLSEDMQSLCQEERVQYIPPKRI
The following text describes a protein:
Function:
Positive effector of CLE45 peptide signaling. Post-transcriptionally regulated amplifier of the CLE45 peptide signal that acts downstream of BAM3 in the regulation of the transition of root protophloem cells from proliferation to differentiation; thus preventing primary root elongation but stimulating lateral roots development.
Miscellaneous:
MISCELLANEOUS: Less stable in procambial than in phloem pole cells.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol. Note=Recruited to the plasma membrane upon CLE45 peptide application.
Sequence:
MEALTFMKFWLTNNTTIKPRREIRISESAVDSTTGSEDPDLDLCEGEDSFFELKISLSDFKTPKEKQRLETTTTTTTYSVSNKSKVLPFVDISSKPQQSPTTLLKSGQKFRAFSFKKSEKSTTTEKKKEENNRTSLNVRFRVDDETTTTSFRKTASIARSQQTDDTMFDDSVSKRFFSLIKPLYTKSTKKQSSSTITSPTSSPATREKQRSNIPSGMRSVRRQLGKSRSASAAIGGMSPANRIDESLQVQQDGIQSAILHCKKSFHGSRESSLLSRSTSESSSQEKLSTSSSEDSYLFSRISSDSISEKSMDSLTSIKEQREKISD
The following text describes a protein:
Function:
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Sequence:
MEELCTLGIYGLSNTGQQFAAHHARNQIRVCICDHDDPSFTPKVIAEYRKQNEKRDDADTTVDRFMRPSNTVEEMVSGLNTPRKIIIFNSNSSDGKFELLWNKLSPCLDKGDIVLRWGREEKENAPSHQFHSQSIVNKLAREQANSKEVHLLEMVRLERDRVNTFKSSNTQPDAFLVGGSEDAYNIMQPFLAPYAVTGLVGNSASCAHYALMIQRAIEFGVTQAFAEGSEILKRVAGHYEPTDVARVFVNWAEKGGKILSSYLLDITSKIIYKRDKVSGDGFVLSKIVDSIEVTPSDAWAKQEAIKLKVPAPILGAVLDARLLSGMKDEREDASSVLSELALKDTPSVLKDQISEDLQCAIYCTCMCAYAEGLSIFQAASDVESWDLNIAECVRLWNLPGSFLESDSLRKVHSAVKDDADESSTLMVISPIAAELQEMHMHWRRMVTLSFAYGISIPALSSSLTYYDTYRARTLPVGLIRAQRDYFGGNGYDRIEGAGWFTTNWTKDHTALNKKGLTTTDKPVQLDADGDEKIKTAAKKRKRQTL
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular Localization:
Cytoplasm.
Sequence:
MERAMKIWRKPDLGKYAVGERVKKIGSKAMPPLCDIDRDIIQVELKQPTILPPNLSLATHFNVPYGNVFTKEKAQSSEPIMNRKSVHAEQRSSHESIVSMQGFDYFDLHSLASGGLGSSAANHGNSAIALSDLDLKKPGSFGNIQVGQPEYWLNIPPSHQSNNNIQVATQNSPFETAMLRKSHVPFVGYKDSPKKNVPFVGYKDSPKKNVPLFNPNVLNLTEKEREYLLNRQSSNVNSANAQYVAPTSTDDFSRLYNNARQPDIAKDRLIAGTALGNNTNGKNLGRRGNQFEEGFQLPLMDQVYEQHLQRSNLTNSASTANYPDGLLYQTAYADPLLAQNQLQHVNAYSGESSRLENEYHGGVSSYNLGSLYPESSLSSSVLSSQRRNPLRSSANISHFPSLMKIPNVGPSSNPENFIRENNFASTFMEDLGNNMTRNSGNISELLGRIVYLSLDQNGSRFIQHKLKFASVEERNMMFPEIFDHARELMIDVFGNYVIQKFFDFGSKHQRTQLLNQLTGHVLHLSFHMYGCRVVQKALQIVELDQKIRLVSELEGSVLKCICDQNCNHVIQKCIECLPERNIEFIMSSVKRNIRTLAIHPYGCRVVQRVLEFCNDVNTHKKLMDAILDAASVLAVDQFGNYVVQYILQNGKPEERSALIAKFSGQFVNLSLKKFSSNVVEKCLTYGKPAECQVFINEILGSTEENENLQTLVKDPFGNYVVQKILEICDDKNRELILSRIKIHYEELKMFLYGKNIVARVSKLADCKGRGMSNFET
The following text describes a protein:
Function:
Required for normal inner ear hair cell function and hearing.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAPGMSGRRGAALLCLSVLLAHAASRSHPASPSPPGTQASPILPVSYRLSHTRLAFFLKEARPLTPAAINGSLQRSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVNWKVRAFIVRARVPASQPVAQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAREVRSSCRLGGALATCLVRAELPLAWFGPPAPAAPPSARRKSPDGLEPEAAAESQQVELYYTLHAPDASGGCGSARRGPGPGPGAAARAESPTQHPLLRIGSISLFRPPPRRAVQEHRLDSNLMIRLPDRPLRPGEVLSILLYLAPNSSSAASPSVEHFTLRVKAKKGVTLLGTKSRSGQWRVTSELLTGAKHSTATVDVAWALDTPLPPWEGQGPLEILQLDFEMENFTSQSVKRRIMWHIDYRGHSALPDLERAVTELTVIQRDVQAILPLAMDTEIINTAILTGRTVAIPVKVIAIEVTGLVLDVSDLVECQSHSEDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLSAPLEMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDEEEEEEERRQSANRGCTLQYQHATLQVFTQFHTTSSEGTDQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQAQVVASLTLSLRPSPGSSHTILATTAAQPTLSLVKQEALLSLWLSYSDGTTAPLSLYSSRDYGLLVSSLDERVATVTQDKAFPLVVAEAEGSGDLLRAELTISESCQKTKRKSVLATTPVSLRVHFGRDEEDPTYDYPGPSQPGPGGGEDEARGAGPPGTAIPAGEVPGLGTAGPVPPTEDYLPLPTGFLQMPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNGQPLRVQGELSPPAGSALETVPACCHGDHHSSGSSQTSVQSQVHGRGDGSSGGSARDQTEDPASSPTSKRKRVKFTTFTTLPTEELAYDSVPAGEEEDEEEDLGWGCPDVAGTTRPTPPPDLHNYMRRIKDIA
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted.
Sequence:
MAARSSKRQDSECSTAPLADDIYERKACNSHCTLVVLCSVLAFFCAGLLAGLATMWVYFGQQIDQLRSAYEKLDLPGHGSDRWNITATVDEAVRMLLEQEEDQKAAADHTQVGPPIQTGWSPGSRKPMAHLTGNPRQNLRKHHGEVKLRSWESEQGLATLANGMKYRGGNLIIPVDGLYYIYSQLSYRFLNENPEEHSDKDANIFQLIHYTFKQSSYPEPQLIMKSSRSTCWSKRTEFGLYTSFQGGVFRLEKGDKVSISVSNAQMISFEESSSFFGAFMI
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. Required for female meiosis and early embryonic development.
Subcellular Localization:
Nucleus.
Sequence:
MAAMQKKVIIVDSKSYFDKLIDDAGTNKYVLVEFFATWCGPCAMIGPRLEQLASDYFGRMLVLKIDVDENEDLAVQYEVNSMPTFLIIKNRVTLIQFVGGNVERVVSTVEKFVGKVEDSKEHKSKEGGASSATVPKLER
The following text describes a protein:
Function:
Transcriptional regulator of pseudohyphal growth.
Miscellaneous:
MISCELLANEOUS: Present with 1710 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDIEPTFKGYIEDEDDALLILQATLDGKLKHIPRRPYEIERPYLIVSGSIFVFIEEISGIKRWTDGVSWSPSRISGKFLIYKELDKENAGSNANATSSGSTDSAVITDGTSGARNNPSSSKIKLPPLKNHQFDLPPTMGHSSFESEQDTSISPSNRSNLPLKYTGLVKKTISVKLKRPPFNSIENLHIVSYYSVKDIKQNCLVTPKASPFLKDVRPSQELIVAMGNTTLGNVKNNSTTTGNGPNNINNKSNSSTPLNTVISTNNNSANINAAGSNQFTSANKNYYYKNDESSGYPITQFAPALPSTTLMYTANPPYITQSPDNTNATGMNTHVNNNNNNSNNSSNSNNSNNNNNNNNNNNNNNNNNINNINNVNTNAGNGNNPNRFHNASFAYNTTGDFINPQQQGQISYPFYYTTIPINNPNYYTTQPPNPVTNASTNENQGYSTSSTQHPYYGHPTESQSASAAAGATGTPGTAENVLPVSSMQPLLHQANNNSASSATSTAPYPVYSMNVNVPYYNSSASAYKRAQENTTSNTNAEPSGATSTNSGTMLSNPAYANSQYTPSQVYYQGFPQYAMASAQNPSMYQHQHQHPLPTVYPIATPQQNIMSSGHTLSTIGSDPQHHHYQQEPNDHKNFAMGHANNNILNITNNDTMNNLNTNTSTTTQ
The following text describes a protein:
Function:
Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGFSFSSNRFGYLTVTFLLVISCLLLGFFTNPVDSSALRPKSEHDCSALKHFHDYKSKCAYLKSIDPCASQGFFDYLSFLYCNFEGFPILGQFLLFLWLLLLFYLLGHTASEYFCSSLESLSKLLNLSPTVAGVTLLSLGNGAPDLFASLVSFMGESKGTYDVGLNTVVGGSGFVTCVVVGIISISLHKRRVRIERAAFIRDICFFCAAIGSLALILVYGKINFWGALGFCSLYAVYVAFVVLSWRFGGDQGAESDLESIHKRGSLSEPILQRDGLEEIEDGVVNGEHQIVDDDDDHQRYYYWKRLVIWAITLPLNLPRILTIPVVSEDKWSKPLAVASVTFAPVLLSFLWNWKRKPTSFEAGVVYLIGCLIGIALGFIAGATTKKLTPPKKWLLPWLAGGFVMSMTWSYISAQELVALLTSLGYIFGVSPSILGLTVLAWGNSIGDLITNLTMALHDGNEGAQVAVSGCYAGPIFNTLFALGISLVGCAWEAYPLSIVIKTDPRLLESLGFLVAGLVWSFLVLFSNRMRLGGVMGIGLLVIYLASLSLRIMQTVGDAH
The following text describes a protein:
Function:
Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermidine, spermine and the antimalarial drug quinidine, but not quinine, chloroquine and mefloquine.
Miscellaneous:
MISCELLANEOUS: Present with 21400 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPSSLTKTESNSDPRTNIQQVPKALDKNVTNSGNLDSTSSSTGSITEDEKRSEPNADSNNMTGGEPIDPRDLDWDGPDDPDNPHNWSSLKKWYTTMTSAFLCLVVTMGSSLYVSSVPELVERYHVSQTLALAGLTFYLLGLSTVIGAPLSEVFGRKPVYLFSLPVSMLFTMGVGLSNGHMRIILPLRFLSGVFASPALSVGSGTILDIFDVDQVSVAMTYFVLSPFLGPVLSPIMAGFATEAKGWRWSEWIQLIAGGLILPFIALMPETHKGIILRKRAKKRNIALKKFSREAQKEFLKTTVTITILRPLKMLVVEPIVFVFSVYVAFIFAILFGFFEAYAVIYRGVYHMSMGISGLPFIGIGVGLWIGAFFYLYIDRKYLFPKPPAGTQPLTEKERTSKRTTPYRGARDAETGELLPVVPEKFLIACKFGSVALPIGLFWQAWTARSDVHWMAPVAAGVPFGFGLILIFFSVLMYFSTCYPPLTVASCLAANNLLRYVMSSVFPLFTIQMYTKMKIKWASTLFALVCVVMIPIPWVFEKWGSKLRHKSQFGYAAMEKEAETEGGIDDVNAVDGELNLTRMTTLRTMETDPSTREKPGERLSLRRTHTQPVPASFDREDGQHAQNRNEPISNSLYSAIKDNEDGYSYTEMATDASARMV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. uS3m is essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MKLKLLNMILSMMNKTNNNNNIIINNTLDSLMNKKLLLKNMLLDMNNKKMNNMKRMLNNNNMNPAGANPVVHRIGPAGNINNKLQHLNNMNNWNTQIYNYNKNMEIMNTMNDKLINKLLYKMMTLKLNNMNINKIIMSKTINQHSLNKLNIKFYYYNNDINNNNNNNNNNYYMNMMNKLMNIMNNNMNNNLCNILSYYYKKKVTIEPIKLSYIYLNSDIFSKYISLNDMDKYNNGILTNYQRMLNNIMPKLNDHNISMNYINNINNINNNKYNNMINLLNNNNNINNNNNYNNNNNNYIGNINNIYNNMTIDNIPMDILMYKYLVGWSIKFKGRLSNNNGRTSTTNLLNGTFNNKKYLWSNINNNYKLNYIPSNHNLYNNSNINKNGKYNIKVKLNFI
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKKKHGTVQSADETIAAAGFAGEAAQGKGEDVQSVAAEERIRQLETELAAKEAEAAANWDKFVRERADLENYRRRTQKEKEELLKYGNESLLQDILPVVDSMERALGHADSESLSAVIEGIRMTHGMLLGTLKKFGVVAVEAERGTVFDPAYHQAMCQVEVSELPPNTVVEVFQRGYLLNERLLRPAMVSVATVPKDAA
The following text describes a protein:
Function:
TY1 element enhancer binding protein. Binds to the DNA sequence 5'-TCGGTGGTATTATTCCGA-3'.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MTAPLWPNKNEKNHTVKRALSTDMTSNILSSTNASSNEENSRSSSAANVRSGTGANTLTNGGSTRKRLACTNCRNRRKKCDLGFPCGNCSRLELVCNVNDEDLRKKRYTNKYVKSLESHIAQLETNLKNLVQKIYPDDEQILNRMMVGDVLSALPDSSQVSINYTDQTPSLPIPATRGTFIIENDKVSQPLSSFNQQTEPSTLNSGIFNTQKQNFEESLDDQLLLRRSLTPQGEKKKKPLVKGSLYPEGPVSYKRKHPVKSDSLLPVSSLTAATDPSTFSDGITAGNSVLVNGELKKRISDLKTTVIVRGLNDDNPNSINNDPRILKSLSNFYKWLYPGYFIFVHRESFLYGFFNHSKNNYEDSSYCSVELIYAMCAVGSRLTPDLQEYSEVYYQRSKKTLLQLVFDEQSTARITTVQALFCLAFYELGKGNNQLGWYFSGLAIRVGYDMGFQLDPKVWYVDDNNLQLTQSELEIRSRIYWGCYIADHFICLMLGRTSTLSVSNSTMPESDELPEVNGTEEFRFIGRHVLQISLPLKNLIILSRLVQIFTSKIFIESEDIARKLKYLNTFNSQVYNWRQSLPEFLQWSKTLIENDDVSTDPTISYFWYCYYIVRLTFNKPFIEDSQESETVVIEIIDDLKTLLDNFGKKFGNYTKGNLYQLYSCLLAINCLKKLKEIRSSEQDSWNAQLDFFNHIFYTQLYPAYDLPKKLQEDTELETEQENQMLNQVGNINYTHDFSLSHEIDDLIRELFGVGTPQKL
The following text describes a protein:
Function:
Inhibitor of Ras signaling. Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (By similarity). Together with Nf1, plays an important role for normal sleep behavior, mainly during the night. Might affect sleep by modulating GABA signaling in Rdl-expressing neurons. Might play a role in the regulation of brain glycogen metabolism and organismal levels of triglycerides.
Sequence:
MLKSISGGVGVASTERGGGGGGCGGGGAGGSASGSRSTSGSGRASCGLGSSSISSGLSAVCGFVTGASGGGGFERDRDRDRGLANISGGSTPAGILYCPACMAAANQQSPSQNSSPHHESFFLRSSFKSSKRNKARKSASTAGCLDAQHIRANLRMSMSSSMRSSRGNGGGGAASSSHPPGSSCSSGPGGSGCSMAYDAASNASSGSGSGSGKATSPGSYSCNALNVDFTSYTATHQWTRMLECAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNLTGENQWEEVDQLGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADSTLPNDLHCYDLDSQVWSVIQPEQNSDVPSGRVFHASAVICDAMYIFGGTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFFQDKQFCDIQFIVGAEEIRILAHIAFVAARSKYLRNKILAAREARQQQMEKVYGVGQVDALALNAGAGGDRGPMLEVRLANASPEAFEIILNYIYTDRIDLKDTYSKNIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINKLNVLEALYNADKSNIKIIKDHCMQFIIKEENFTDVVMSSEFSDLDKPLLVEIIRKRLYPSKLVIDTSYEGNIGTTLEIDLCAFLESTGKDFCDISLVLEDHVIPAHKSVLSSRCTYFQGMFRSFMPPDNTVNIQIGEISPSLEAFHSLLRYIYYGETKMPPQDALYLFQAPCFYGLANNRLHAFCKYSLEHNITFENVLQTLEASDITKIYDIKEYALKLIVKDFAKVARLPKIAGLSRELLLEIIRAVADSHGEFLTRININTDI
The following text describes a protein:
Function:
May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTSVPVIPESYSHVLAEFESLDPLLSALRLDSSRLKCTSIAVSRKWLALGSSGGGLNLIQKDGWKHRLFLSHREGAISQVAFCLHDDDYVAVATSQGLVVVWELNQERRGKPERIYMSSEHKGRKVTALCWDTAILRVFVGDHMGKVSAIKLNTSKQAKAAAAFVMFPVQTIMTADSCVVQLDFLDGRLLISSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSADQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLLSSPPLPVITLRTEPQYDHTVGSCQSLSFPKLLHLSEHCVLTWTERGIYIFLPQNVQVLLWSEVKDIQDVAVCKNELFCLHLSGKVSHLSLLSVERCVERLLRRGLWNLAARTCCLFQNSVIASRGRKSLTVDKLEHLKSQLDLTTCSDLISQLEELILKFEPLDSACSSRRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQTLSEDERLKEFASHQEEDQPDQCCGSQGNEDNVSHVPVTFETEKNETFLPFGIPLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRPEPRGDEQSCEEDVSPVICPKEEDTEEEKEVTSQPPEEDKLQELRIATAEAMTKLEDPLVLFEPKSLRMVLQQWLSQLEKAFAIKDFSGISDAGNSSMTSNQDVLLLDESKKGILDEDNEKEKTASLSNEETVDQTVCDSVNNLREPLDDLFQVCSPCSIANDLQKDLAELTTLCLELNVLNSEMKSTSGHADHTLQQCSPETLACQFLKKYFFLLDLTRAKESIKLSYTDSPCVWDTFIEGLKEMASCSPTYMEMGEGDLPTRLKLLDDSVPFDSPLLVAYAARLYERFGESALRSLIKFYPSILPADVMQLCHHHPAQFLAYLDSLVKSRPEDQRPSFLESLLQPESLRLDWLLLAVSQDAPPSTSTVDEEGDPRPHSHLFSWGYSQLILHLIKLPADFTSKEKMTDICRSHGFWPGYLILCLELQRRKEAFTNIVYLNDMSLMEGDSGWIPETVEEWKLLLHLVQNKSTKPAPQKSPNGNFNDGPSPINVENVALLLAKAMGPDRAWSLIQECGLTLELSERFTRTCNILRIAEKRQRYSPSVMPLSCPLHPESPSFLRLNSIPLNGYMTFYLSIHLLMYAWVASTSWLL
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLRCAPAICLQRRTYTMYSQPSQLQGGLSQSMALWKHSRSHAVSYQTKMGLVSLSPKSTTSSHLQNGTCFACLEQQSKHGLSARDRILHAKLDMASHHGFSSISWKSRTTRSLAQKIGGTGAGLSLSFTVAGIANAGGPVDNDIDSKSSSSCAHGKKVYTEYSVTGIPGDGRCLFRSVAHGECIRSGKPIPSENLQRKLADDLRTLVADEFIKRRTETEWFIEGDFDTYVSQIRKPHVWGGEPELLMASHVLQFNFKTWPFFATVRCQSSKNKHHFVFRMPITVYMHEEAAGGLIAIAEYGQEYGKEDPIQVLYHGCGHYEALHIPGNAEPRSRL
The following text describes a protein:
Function:
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MGRGILNFNVYDGSLEAIVHGYKDGFLRPEEYASLVQCDSLGDMKSQLQVTDYGNFLQHDGQAQLSARVIVERAQEHYAKQLRELRSWAAPPLSHFLDFITYEHMIANVLKLIIAKRSGRDGMQLLTRCHPLGWFPELASLTAAADVREMFEVVLIDSPVGRFFNANGGLESDLDELSVEYIQGMLMKNYYEQFYDLCCELGGATAEVMCPLLELEADLTVLRSTVNTMGVPDIHATDRRRLFPSFGSLVDIHDDIAEAESVEQLRERVRRFGLMHELLDDSRYNSTSSSSAKGGNNNRGNNAVSGAASGQTGASAAGASSLERRFVEVTVALYRDALSRQFQYGVFYAWAKLKELEVSNLHWIADCIAQGMMHRVDEYVSIF
The following text describes a protein:
Function:
Putative COX assembly factor.
Subcellular Localization:
Mitochondrion.
Sequence:
MSTSVPQGHNWTRPVKKDDDEEDPLDQLITRSGCAASHFAVQECMAQHQDWRQCQPQVQAFRDCMSAQQARRREELQRRKEQASAQH
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
GSHWLILILLFSSFHFSSFQLFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDRNDTVYFDVVERSTGKIVDKSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLVSQTPLLKECGFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKTQIPEGRVSQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLFFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVSKEEGARPGTLLGTFNAMDPDSQIRAKKGSCLSGNGHITKRPIDRESPHVNNSFYIIIVHAVDDGFPPQTVTGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFAFELDNTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGDKQGLSQKQTVRVRICPCASGLTCVEHADAEVGLLVGALFPVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKATSAQTWSDVEGQRPALLICTAAAGPTQGVKDLEEVPPSAASRSAQARCALGSWVSSGRLLPATAISLVTNRWSP
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MSADSHQLHTHSHKDTLSSTCRGLLNVNSHPLSKSSSSLICAGHSSLERQSNKQELKKSHSSTVCQTLGHDSDARSAPSPRWSFSQSGLMGLESVVQTINNQSPDNNSQSRTKTTNHFLIIEQSPASWEVGDTKMCVKSSTVENVSSACFKHQQSMGKMDEPRAVLQRSHSDLTCSCKQQSYVTHVETSATDSSLSSSSSRHGPSVVRMSFQTERYGSEINENTSHYQNLVTHLPALPIDQKVPTNTFDSGGIPHNTTVYTDPGRFHSAVLGPHMPGNGFSNRTMFSQATGIIHGGLTYSNIPNSAFSPMAMTVHNSSAVPCNIRQDSCMKVDATIPAYCHSLPIPSIQLVPRLVCSVSESGKEQAAPDYFHSFSTSDILTYPKLVSSVSESGLDAKRVLKCCSVPGEQLQHAQRCTQQERASSETQTACVAFSSQQTTDVAMKTKDMWTMTSANDLTKGLKPALERRDAEVQTLPTMECKSVATSPAAAAEGHSHVFPEVNLEQDLEAPKSPVREVRWDDEGMTWEVYGASVDPEVLGLAIQKHLEIQIEQFQTEPAQQTGKSDEDPLNKEPSSDKMEKKRPFRTMMHSLRYPSCCARSSTAVE
The following text describes a protein:
Function:
Zeaxanthin epoxidase that plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. Converts zeaxanthin into antheraxanthin and subsequently violaxanthin. Required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression and disease resistance and non-photochemical quencing (NPQ). Through its role in ABA biosynthesis, regulates the expression of stress-responsive genes such as RD29A during osmotic stress and is required for normal plant growth during vegetative development. Is required for late skotomorphogenic growth through its role in the xanthophyll carotenoids neoxanthin, violaxanthin and antheraxanthin biosynthesis. Required for beta-aminobutyric acid (BABA)-induced priming in disease resistance, tolerance to salt and drought stresses and sterility. Participates in NPQ by regulating the level of zeaxanthin in photosynthetic energy conversion. NPQ is a process that maintains the balance between dissipation and utilization of light energy to minimize the generation of oxidizing molecules and the molecular damages they can generate.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing ZEP show increased levels of violaxanthin and ABA and increased tolerance to salt and drought stresses.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MGSTPFCYSINPSPSKLDFTRTHVFSPVSKQFYLDLSSFSGKPGGVSGFRSRRALLGVKAATALVEKEEKREAVTEKKKKSRVLVAGGGIGGLVFALAAKKKGFDVLVFEKDLSAIRGEGKYRGPIQIQSNALAALEAIDIEVAEQVMEAGCITGDRINGLVDGISGTWYVKFDTFTPAASRGLPVTRVISRMTLQQILARAVGEDVIRNESNVVDFEDSGDKVTVVLENGQRYEGDLLVGADGIWSKVRNNLFGRSEATYSGYTCYTGIADFIPADIESVGYRVFLGHKQYFVSSDVGGGKMQWYAFHEEPAGGADAPNGMKKRLFEIFDGWCDNVLDLLHATEEEAILRRDIYDRSPGFTWGKGRVTLLGDSIHAMQPNMGQGGCMAIEDSFQLALELDEAWKQSVETTTPVDVVSSLKRYEESRRLRVAIIHAMARMAAIMASTYKAYLGVGLGPLSFLTKFRVPHPGRVGGRFFVDIAMPSMLDWVLGGNSEKLQGRPPSCRLTDKADDRLREWFEDDDALERTIKGEWYLIPHGDDCCVSETLCLTKDEDQPCIVGSEPDQDFPGMRIVIPSSQVSKMHARVIYKDGAFFLMDLRSEHGTYVTDNEGRRYRATPNFPARFRSSDIIEFGSDKKAAFRVKVIRKTPKSTRKNESNNDKLLQTA