lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MTTNLWVKQKWFDYKLRWDPEEYGGVEMLYVPSEQIWLPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQTCLMKFGSWTYNGAQVELRHLDQIPGSNLVQIGIDLSEFYLSVEWDILEVPASRNEEYYPCCPEPFSDITFKLTMRRKTLFYTVNLIIPCVGITFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNVWYRSTSTHKMSPFVRRLFLEIMPKILMMRRAKYTLPDYDDSTPSNGYTNEIEMSVSDFPGEFKEGGDSFDNIGVNLSHGSVEAENVIPKQLSPEVLSAIQAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWVFTISCIFGTFGIIFQSPSLYDTRAPVDQQLSEIPLRKNNFMLPPDIVRITLD
The following text describes a protein:
Function:
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to the ciliary transition zone.
Domain:
The 2 PHD-type zinc fingers are required for transcriptional activity.
Sequence:
MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRPEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEYVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKAEEGLGEGTAQENGAPECSPRDPLEPFAGLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVMTDTDTL
The following text describes a protein:
Function:
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Subcellular Localization:
Cytoplasm, perinuclear region. Cell projection, pseudopodium. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
Sequence:
MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPIQSPLPVIPHQKDPALDTNGSLATPSPSPEARASPGALEFGDTFSSSFSQTSVCSPLMEASGPVLPLGSPVAKASSEGAQGSVSPKVLPGPSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGAGLLGGSLPVKDLAVDSASPVYQAVIKTQSKPEDEADEWARRSSNLQSRSFRILAQMTGTEYMQDPDEEALRRSSTPIEHAPVCTSQATSPLLPASAQSPAAASPIAASPTLATAAATHAAAASAAGPAASPVENPRPQASAYSPAAAASPAPSAHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASSYSPSPGANYSPTPYTPSPAPAYTPSPAPTYTPSPAPTYSPSPAPAYTPSPAPNYTPTPSAAYSGGPSESASRPPWVTDDSFSQKFAPGKSTTTVSKQTLPRGAPAYNPTGPQVTPLARGTFQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFNCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPICAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDKPLCKKHAHAINV
The following text describes a protein:
Function:
Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MVELAPPVAVSPFIRACRWGALTAGVFYGAYHFRRLSRKETKLREYEAQQMELMREKREEEKRKKNREEMIALAKDTGTPIPPNF
The following text describes a protein:
Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MANILKKMPRFTVKFSSAFTKSERSLSECPLELSLSLCDDESCKPSESFEEEKCPLHEEEGSVGSTEKGTTPSVTEDEERPEKAEEERSEKEEKGEGLAPEVSCNMSLQGEEKQEFSFTLYDFNGHGKVTKDDIASLVRSIYDALGKKSLPKSGSRTIKVRLAIGPDEESGEGKLPAPEKPPPSSRNSSATTACTLLTDDASAARRSQQPESLSVPVHRKFPPQVENVDVAGSKCKHNSGALPSSPLGSRSRRFQSRIHERQELLQWLRDSTEKACQQSATAQDNRRSQPPRQKEVGPEACPWEKTPEPAPCPYRLLDHGHDCAQWSPQCERRPHRRSKSHGEGGGAAPCSGTHHHYRHRERDLERQRAMRQVASWIQREHLASMDCSRGTRPERHEHHHLHEHVHHHYHHYVD
The following text describes a protein:
Function:
Probable protein kinase required for meiotic recombination.
Sequence:
MRPLYSCNLATKDDIEMAGGVAPAHLEVNVGGYNTEQTIPIVKHQLVKVGRNDKECQLVLTNPSISSVHCVFWCVFFDEDSIPMFYVKDCSLNGTYLNGLLLKRDKTYLLKHCDVIELSQGSEENDIKKTRLVFMINDDLQSSLDPKLLDQMGFLREVDQWEITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWIAKHLSQLERLYYKKILCNNEGPKLESINSDWKRKLPKSVIISQAIPKKKKVLE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTDPKEVLSLDVQAPEVWEELLTLKVEAESHFQMQESRLKRNNPLAREIFRRHFRQLCYQETPGPREALTRLRELCYQWLRPHVSTKEQILDLLVLEQFLSILPEELQGWVRERCPESGEEAVILLEDLERELDEPQHEMVAYRLGQEVLPEGTVSLGEQMSLGLQSQPKEPQLTCDPAQEPQHIGETDGMMETEDRELVLRKDCPKRVEPRGKMSYEKTWEVSQQDPRHGEVGERKGGMEQYWGGPLGDPPHRCEECGKSFAQSSGLIRHQRVHTGERPYECNECGKTFSRSSGLFNHRGIHNIEKRYHCKECGKAFSQSAGLIQHQRIHKGEKPYQCSQCNKSYGRRSFLIEHQRSHTGERPHHCNKCGKSFNRHCNLIRHQKIHTGAELV
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit polr2a, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin and transcription pause-release checkpoint.
Sequence:
MNKIFGVKIDSQQKKRQQSNKNLTVFNNGRYLIYIGDIHFDRKFHREALRYYLLGCGLETAFYSDPVKTSVTNSKYLTFLSRRIFDCFYFLRAPMQAIVVSQFFGNLNQTCLVSFKIIQEEYYQLDTNYFQYIWELPLLEILLTTFTKQKDLKKIYLINQIISNPIINENNHPDIRKNFIKNTKHNFWKAISSNYLLQ
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion. Plastid, chloroplast.
Sequence:
MGSSIKALHLLKPATDSFFFSFTKNGISSLPLSIKQRRSYSMKSSVLEPPDVPRLAETARISLIPQQVEEFAPKIRQVIDWFGQLQAVDLQSIEPALRADTEGDNLRDDVPEKFENREALISVVPSFEEPYIKVPKVLNKE
The following text describes a protein:
Function:
[Halocin-C8]: Has antibacterial activity against a wide variety of haloarchaeons. Causes cell lysis and death, possibly by disrupting the cell wall; [Immunity protein HalI]: Acts as an immunity protein for halocin-C8. Able to block the halocin-C8 activity by sequestering the activity of halocin-C8 through specific and direct binding.
Miscellaneous:
MISCELLANEOUS: [Halocin-C8]: Is quite robust, as it can be desalted, boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.
Subcellular Localization:
[Halocin-C8]: Secreted. Note=Secreted; [Immunity protein HalI]: Cell membrane. Note=Exclusively localizes to the cell membrane.
Domain:
The helix-loop-helix (HLH) region is essential for immunity function of Immunity protein HalI and interaction with Halocin-C8.
Sequence:
MKEDNNTSEESGRINRRNVLKTVGAAGLFAAGSTGMAAAADSLSQAEEPKLLTGTEKRTLARELAKTPAFRELAQRARADGAQIRSDADSIVAGYARGEDFAREVVQYDLENLTDAAEASIVIGRNPETGEIEVANLDYYYETDDGVLDEVHRFEPTNASETDGVQSAATSDGATVIAVDTDAIREAQNSEIDVDESSPSNAAPTPADIDITGCSACKYAAGQVCTIGCSAAGGFICGLLGITIPVAGLSCLGFVEIVCTVADEYSGCGDAVAKEACNRAGLC
The following text describes a protein:
Function:
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKFSGLFPFLLLALGTLALWAVEGAENEALKAGACPPRKSAQCFGNEKPRCSSDWQCPHKKKCCLDTCGTECLDPVNITNPVKKKPGTCPVIHGQCLMLKPLNHCETDDQCIGALKCCKAMCGKVCLSPVKA
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase. Has no effect on the stability of the DELLA proteins.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MAVEAHHLNPLFSSNREMIHPVEASGVVYNTQMRYGTVPTFNPTVECQTSLFNPIYNISPVDRLVHQSMKPTIQSVDSSLTFNSDNNVDFLRPVSSRKRSREESVVLNPSAYMQIQKNPTDPLMFLGQDLSSNVQQHHFDIDRLISNHVERMRMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLEEKVKSLCVENQIWRDVAQSNEATVNALRSNLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKGEASVLLLPCRHMCLCSVCGSSLNTCPICKSPKTASLHVNLSS
The following text describes a protein:
Function:
Involved in pharyngeal muscle development and ensures pharyngeal grinder function during feeding. Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine. Has a role in the determination of life span.
Subcellular Localization:
[Isoform a]: Nucleus.
Sequence:
MPLESGKLINDLRVSELKTELEKRGLSTQGVKVVLTVRLNKALRDEGLDPADHVFEHAVSPMKKSTRRSNEMARAAAAAAAEKVEKGAGDEGNDENVLVEEKEEEEEEEDSHDLQIIEDHELEVPSDEKDDTLVEDEEFEEAEQVEPEPEAVEPVVEEKPEEKLEEKPEEKLEEKPEEKPVEPEVVTVEEPVAEVIEVEKAVAEPVELKEKPEKEPEVVLVEEPVEQLENEPEVVPMEVEEAKKSDEQDGEDEFEEDDSSSDIEIIEPTLQESEPLAEEKVEKKEKKPEEIPHNLEQNEPISMETEEKVEEEVIILNSSINNVSQDDEIVLDYEEDLLEDPLDEPIEQKEPKAAEPTPKQLQKVEASTPQATPSKAASSSAGSGKSMLFGDDVKKTSIWIRGMTPATKASSVKQLASQYGKVIQSKIFNSKAADANGDVKNCFALIQFADVTAMELAMTSLHQKNYQGRVLRVEKVSESHLTSSAEKLAREKHVAEAASTMSTSPAPTPTPEPVVTTTTTTSAAPKRKEPIHAPESSSSEGQRAKRRAIEAPVRSRSRSRGGGGEPRSSRKPITFDREEESNRDSRRTIAAAPPARTSRMARSPLRAPLRAARGSESSRSSTRGGGGGGESLTISSRVDTSGCRGGAIKRSVERSVPNNISTSELRRKHHQIHVTVQQDAPRASYQTEQYARERSSSTTTSSRRRQVSPDRSEQRRHRDEPPPRRAPQEQPSRRRGASPPEPPRRQEGARRSEEPERRRLFDEREQLAHIMAAKDMYAEQQKIRAEKALIAFQMQQLEKKKLEAELQIAQKALLMQQAALGGGGALVVDGGALVAGGGAVGYHHQEHRSSYGGGGSSSNGGSSNRRRQTRRSPSPPQQHHSSSRRQRRDSGGAGRYRQSTSSSNSNRNSNSGGRNLVVTATTTNNTNATNAGRSYGIQSVPDASSYSTNNYQQRSSAASAYDLQITATMPQAGAANSGAAYHQPYGNVYQHNTAAYPVWGGLDAQGHMAMDTNWSQNAATPSTSTSSGGGGGQQWQQQSYGSNQHQHHQNNNSSQPSSSNRRGNDYGNYRGNY
The following text describes a protein:
Function:
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.
Subcellular Localization:
Chromosome, telomere. Nucleus inner membrane. Note=Localizes to telomeres during meiotic prophase. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane.
Sequence:
MESEDTKKTQEMKTDLNLLLECLKYQMDNAFSQKEALVTIHSICQQNSNASVYFREIGGLMFVKNLAKSSEHSMVKEAALYTLGAIAEKNVYCQQTLCTSELFEDLTWFLSNDSNINLKRMSVYVILVLVSNNRTGQTLVRETGCITVLSRLFRTVISKHELDLSDKNVFQSYQLWSSVCSTLCVCVNNPQNDENQMFCCSLFPHANEWLKNCTTPEIIRPICSFIGLTLANNTYVQKYFVSVGGLDVLSQVLMQLESDSHETLSSAKLAVVVTKTVDACIADNPTFGIVLSKYHIVSKLLALLLHESLDSGEKFSIMLTLGHCTEDCEENQYDLFKNNGLPLMIQALTESQNEELNKAATFVLHNCKKITEKLSLSLGEYPFDENETQQLKDISVKENNLEEHWRKAKEILHRIEQLEREGNEEEIQRENYQDNISSMNISIQNTWKHLHADRIGRGSKAEDEDKSHSRQLQSYKSHGVMSKACTNDDQMKTPLKSANPVHACYRESEQNKTLYKAKSSCNQNLHEETTFEKNFVSQSSDHVFKHPVHIAKNIKQQLPVTDPFTLCSDIINKEVVSFLATPSCSEMLTYRCSGCIAVEKSLNSRNFSKLLHSCPYQCDRHKVIVEAEDRYKSELRKSLICNKKILLTPRRRQRLSNESTTPGGIKKRRIRKNFTEEEVNYLFNGVKKMGNHWNSILWSFPFQQGRKAVDLAHKYHKLTKHPTCAAS
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MAGFRQGPDDFSFPYTSTRTAHDRLHGCLLAAGFDQEACHSRYQSAMYRRNPGRGPSEHLVSKLRRHEALQRRCGPGTAAYSSALEQLKSGKNAGESPVNLKCRYLVSISYRGLGNRIIAAASVFLYALLTDRVLLVDSSNEMGELFCEPFPDTTWLLPWRSFPLWNFSSDTRPQRRNHHDIHLPFPRARIGGMPRASPGRGPPHALGASRPSHGWRCAAPGSGAQEPARVPAPVYLLQAARPEPHAPITKKPPRHPPPIPSRLDRCSVFVVSARLTG
The following text describes a protein:
Function:
An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction. Does not unwind more than 18 bp of dsDNA. May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA. The core helicase domain binds ssDNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MERLRDVRERLQAWERAFRRQRGRRPSQDDVEAAPEETRALYREYRTLKRTTGQAGGGLRSSESLPAAAEEAPEPRCWGPHLNRAATKSPQSTPGRSRQGSVPDYGQRLKANLKGTLQAGPALGRRPWPLGRASSKASTPKPPGTGPVPSFAEKVSDEPPQLPEPQPRPGRLQHLQASLSQRLGSLDPGWLQRCHSEVPDFLGAPKACRPDLGSEESQLLIPGESAVLGPGAGSQGPEASAFQEVSIRVGSPQPSSSGGEKRRWNEEPWESPAQVQQESSQAGPPSEGAGAVAVEEDPPGEPVQAQPPQPCSSPSNPRYHGLSPSSQARAGKAEGTAPLHIFPRLARHDRGNYVRLNMKQKHYVRGRALRSRLLRKQAWKQKWRKKGECFGGGGATVTTKESCFLNEQFDHWAAQCPRPASEEDTDAVGPEPLVPSPQPVPEVPSLDPTVLPLYSLGPSGQLAETPAEVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPCLKAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFACIDEAHCLSQWSHNFRPCYLRVCKVLRERMGVHCFLGLTATATRRTASDVAQHLAVAEEPDLHGPAPVPTNLHLSVSMDRDTDQALLTLLQGKRFQNLDSIIIYCNRREDTERIAALLRTCLHAAWVPGSGGRAPKTTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQGEDLRELRRHVHADSTDFLAVKRLVQRVFPACTCTCTRPPSEQEGAVGGERPVPKYPPQEAEQLSHQAAPGPRRVCMGHERALPIQLTVQALDMPEEAIETLLCYLELHPHHWLELLATTYTHCRLNCPGGPAQLQALAHRCPPLAVCLAQQLPEDPGQGSSSVEFDMVKLVDSMGWELASVRRALCQLQWDHEPRTGVRRGTGVLVEFSELAFHLRSPGDLTAEEKDQICDFLYGRVQARERQALARLRRTFQAFHSVAFPSCGPCLEQQDEERSTRLKDLLGRYFEEEEGQEPGGMEDAQGPEPGQARLQDWEDQVRCDIRQFLSLRPEEKFSSRAVARIFHGIGSPCYPAQVYGQDRRFWRKYLHLSFHALVGLATEELLQVAR
The following text describes a protein:
Function:
Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.
Miscellaneous:
MISCELLANEOUS: Present with 106000 molecules/cell in log phase SD medium.
Sequence:
MTEFELPPKYITAANDLRSDTFTTPTAEMMEAALEASIGDAVYGEDVDTVRLEQTVARMAGKEAGLFCVSGTLSNQIAIRTHLMQPPYSILCDYRAHVYTHEAAGLAILSQAMVVPVVPSNGDYLTLEDIKSHYVPDDGDIHGAPTRLISLENTLHGIVYPLEELVRIKAWCMENGLKLHCDGARIWNAAAQSGVPLKQYGEIFDSISICLSKSMGAPIGSVLVGNLKFVKKATHFRKQQGGGIRQSGMMARMALVNINNDWKSQLLYSHSLAHELAEYCEAKGIPLESPADTNFVFINLKAARMDPDVLVKKGLKYNVKLMGGRVSFHYQVTRDTLEKVKLAISEAFDYAKEHPFDCNGPTQIYRSESTEVDVDGNAIREIKTYKY
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MGDPNGGASVQGEKKPSVSKVPSLIKRWRSRNKSAENGLVPASGSIPAAAAHNESVAEESPASATAAPRAAPETCTSGTLAADGQEPHCHGTPGRRLTILSLDGGGVRGLIPAVCLEFLEQQLQAFDGADARIADYFDVVAGTSTGGLIATMLTAPDVNKRPLLTATQAKQFYLDKAATIFPKPGIFSSVTSLLGPKYSASPMKKILADTLKDLKVTDSVTDLLITTFDTKTQQPVFFDKQVAQRVPRFNATLQDLCLATTAAPTFFPAHQFDVPDPDQGEGKTHQYNLIDGGVTANNPAEVAILHAVKDLCIGDSPHRGRIPEFKGYRDLLVLSLGTGSSIVSYDAKEVASWGSLSWILNDGQQPIIQMLQNSSAYLVDFDIAIRFQIDEVEENYLRLQTSGIVGDMASVDGSSKKNMQNLVDLSNKLLDEKAKYRNAINGELVDKTYLGSNRDALTTFAKWLSEEKKARAELPASVEEAAQLPRDNATPLPSIATTFV
The following text describes a protein:
Function:
May play a role in apoptosis. May act as a tumor suppressor.
Sequence:
MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVLANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGEGLPEALQSLWSLLKSRSCMCLQARAHGAERGDSKRS
The following text describes a protein:
Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
PTB domain mediates receptor interaction.
Sequence:
MESVETPVKDGLLYQQHMKFGKKCWRKVWALLYAGGPSGVARLESWDVRDGGLGPGGDRPAGPGRRGERRIIRLADCVSVLPADGESCPRDTGAFLITTTERSHLLAAQHRQSWMDPICQLAFPSTGECSSGSGQAESPKRGFVPMEENSIYSSWQEVAEFPVVVQRTEATTRCQLKGPYLLVLGQDDIQLRETSKPQACYSWPYRFLRKFGSDKGVFSFEAGRRCDSGEGLFAFSSPRAPDICGAVAAAIARQRERLPELAMSPPCPLPRALSLPSLEPPGELREVAPEYELAPSRKLPLTDPGPQSLPLLLSPTQDGTASSLYASVCKQTSKHKATVEHLYENVFMLEASPGLSNGGPEAQEGPPGGRSPLGSPIYHNSEELSWPGSAHDSNLEAQYRRLLELELDDAGGAGRPGAQTGIKAKLVTLLTRERKKGPAPCDRP
The following text describes a protein:
Function:
Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDVRRRPPKQPSHYHQTSTSDPNLHPPKASDALPLPLYLTNGIFFTLFFSVAYYLLHRWRDKIRSSTPLHVVTLSELAAILSLIASFIYLLGFFGIDFVQSFISRASHDAWDMEDEVESRFIIEEDRRSPAAIGSSISAPVSRFMDPPAPLPSQEEEDLVKSVVSGEIPSYSLESRLGDCYRAASIRREAVQRLTGRSLDGLPLDGFDYQSILGQCCEMPIGYVQIPVGIAGPLLLNGCEYSVPMATTEGCLVASTNRGCKAIYASGGATSILYKDGMSRAPVVKFETATRASQLLFYLEEPANFDALAMVFNKSSRFARLQKIQPTPAGRNLYIRFTCETGDAMGMNMVSKGVQNVLEYLQVEFPDMEVVGISGNFCCDKKPAAVNWLNGRGKSVICEATITGEVIEKVLKTSILALVELNTIKNLTGSAIAGALGGFNAHAANIVSAIFIATGQDPAQNIESSHCITMMEATNDGKDLHVSVTMPCIEVGTVGGGTQLASQSACLNLLGVKGACRESPASNARLLAAIVAGSVLAGELSLMSAIASGQLVKSHMKYNRSSRDMSTVTS
The following text describes a protein:
Function:
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATPTDGSERATTASGADPFGDAARRRNNPPVAPTATEKPQPEDKKKALVPVKKEQSFLDCIASWEWIVAPVVFTFLAFFTRFWQIGLSPIVTWDEAHFGKFGSHYLKREFYFDVHPPAGKLLVGLSGLLAGYNGSFEFKSGETYPEEINYTFMRQFNAFWGAVCVPLAYFTAKALHFKLPAVWLVTLMVLCENSYTTISRFILLDSMLLFGTVATTLCWAKFHNLRKKSFTPEWAFWLFLTGLSIGFVCSVKWVGLFVTALVGLYTIEDLWNKFGDTKMPVKVLAAHVAARVSCLIILPFAVYLLSFAIHFWVLTNSGPGDAQMPSLFQANLRGTEVGRDSPLELAIGSRVTIKNMGYGGGLLHSHVQTYPEGSNQQQVTCYHHKDANNDWFFYPNRREQAYDENSDEIRYIGDGSTVRLIHAQTGRNLHSHEIPAPMTKSDKEVSCYGNLTVGDEKDHWKIEVVKDTNSRDRSKIRTLTTAFRLKHEVLGCYLRAGTVNLPQWGFKQIETTCTKTNNPRDTYTHWNVESHTNPKLPPAEPGQYKSQFLQDFIHLNVAMMTSNNALVPDPDKQDDLASQWWQWPILHVGLRMCSWDDKTVKYFLLGNPLVYWGSTAALGVFGLLVVWYTLRWQRGYKELGQDGIDQIHYAGVYPVIGWFLHYLPFIVMGRVTYVHHYYPALYFAILCFGFLADWFLRAKSKLTQGIAYGILYATVIGLYIFFMPISWGMVGPNQQYKYMKWFDNWRISD
The following text describes a protein:
Function:
Plays a role in the endosomal sorting pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNDKEINSEKSKRAINHFSNKKEIKNSDRRGILFSKLPSQQLNPDRYDNLMTFWNNSLIDISKSCNILIFTPKLLSTYFTVENVSPIYLPLILNEMIKTKFIVKYEEYIKDYGWSKWVWTKMVVQPFQYYTGLSTPNTETEKNVKFILPEMIKDKAEQLYQHQLKNMNSTTDNIISYINLEKSIKDWYITREELDLLLLVLFRDSKVLILTNNKIKNINNNNNGEDRIGIKFAFDGEKVQPIQETDFGILKLQTTYETLKQQESKLLTDIEEISNTIKESIRIKQKNHALLQLKKKKLLESILEKRATASTNIHEILFSIESAKSNQQIIESLCTGVSTLKKVNQEISVDQVDSILDDYQDAITNQREIDDAMKSGFNSVESLSSADIDEDQLEKELDQMLQDHLTLEKEEKQKQKQIEKEKQQQQQPPTSQFNPNLPIPLKNEEDELLKELESLSVTSNPLPKQDENKQKTSELI
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MKRRTARERAMQALYQMDITGELEPKVAVENTLDEGEETNEFLESLVVGFVENKEAIDEAIRQNLKKWKLERISIVDRSILRVAVYEMKYMEEIPHNVTINEAIEIAKTFGDEESRRFINGVLSNIKDTL
The following text describes a protein:
Function:
C-type diheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the liberation of two electrons, which may be transferred from the SoxAX complex to another cytochrome c and which then may be used for reductive CO(2) fixation.
Subcellular Localization:
Periplasm.
Sequence:
MKTMTGRLVAAALVCGGAFSGAAVSAGPDDPLVINGEIEIVTRAPTPAHLADRFDEIRSGWTFRTDDTQALEMDDFENSGMVFVEEARAVWDRPEGTEGKACADCHGAVDDGMYGLRAVYPKYVESAGKVRTVEQMINACRTSRMGAPEWDYIGPDMTAMVALIASVSRGMPVSVAIDGPAQSTWEKGREIYYTRYGQLDLSCASCHEQYFDHYIRADHLSQGQINGFPSYRLKNARLNAVHDRFRGCIRDTRGVPFAVGSPEFVALELYVASRGNGLSVEGPSVRN
The following text describes a protein:
Function:
The fumarate reductase enzyme complex is required for fumarate respiration.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKDMLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASALETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSKEQTKDNMQGVPANEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHFLLHNEGKEDVYEIRERMKEVMDEKVGVFREGKRLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRIEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHELLDQHNANLKGEHHE
The following text describes a protein:
Function:
May play a role in sperm formation.
Miscellaneous:
MISCELLANEOUS: No coding region alterations in either Hemimelic extra-toes (Hx) or Hammertoe (Hm) mutant mice was detected.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRNKDRSSNKGNLAVTAVALQDHLLHDLQLGHLSVADPCKIKARKKEKKSKSLKRDATAIIDTGLRKSTEGPNMEDPEKEYVLDPTPPPLTLAQKLGLLPPPPLPLSSDEWERVKQRSLLQGDSIQPCPICKEEFELHPQVLLSCSHVFHRACLQAFEKFTNKKTCPLCRKNQYQTRVIHDGARLFRVKCATRIQAYWRGYIVRKWYRNLRKIIPPSDAKLRRKFFEEKFTEISHRILCSYNTNIDELFSEIDVCLAVNRSILQQLDERCGQIITKEDWEKIQAQAAHHEIYECSICLTPLSFHGDGRQAAIGTSSQRPRETVLLSCAHLFHNACLLALEEFSLGDNAPFHVCPLCRSCYQKKIVEC