lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities.
Miscellaneous:
MISCELLANEOUS: Present with 7950 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSAIQSPAPKPLQPTYPAASPASTNAYMKPGLIGSPAVSNHTEPNNGNNETAEPQGPNQRIDLGAMIEELTSLLGKESWTKYAQIISLFILGKLSRKELSNELELVFSPSAASLEKSNTNHHHSLVRLHNQLLLGIFANSLRENPLGRNGNESSWGFGNGSNNPNNKLKRINKHNSQIEVYKKIVMSLPLNDRNRLKMITKEAGKRGFIFCSVFQARLNNIPKIPIVTNPESLKRVKSNNLKTPLEWSQDIMNGFNVPLASESHSLPDTDSFYLRMVGIAREHGLVGTVDARCVELISLALDQYLKNIIEFTIDTVRYRRKKYSDYYDLNESGLYKSVSEMAADKRDAKIKQLDDDKNEDECADEAKSINNGNNSSKDDIGDISMSSITKAGEAVNEELHENRTISLTNEDIYDSLSIFPNLVEPSGSYYALTNLGLVNDDELVDMKSNIDDLPDFLNEKPTFTPLDERNVGTRHELNWLIKGILTED
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIEDFSLKDVSSSPGVYLMKDSQGTVLYVGKAKNLRNRLSSYLQKKGDSRKRIPFLMKKTTDIDTIVVSNETEAILLENNLIKKYQPRYNVLLKDDKTFFCLSVSLEHPWPRIEAIRTRALSPGKKKQWLFGPYVSAEACYALLEVISLWFPLRTCSDREFSTRQRPCVLYEMKRCLAPCVGLCSQTEYQETLDKAVLFLKGDVRSTISNLEKAIEKASQEQKFEHAAALYRTLTLIRQTMAKQHVEKFQAYDIDVLGLYRKGSLAIVSVLSVYSGKLLGARYFIFPENAQEDSALFSSFILQYYAENPRIPKEIFVPVSLDSPELPYLLNTAEPPKIRCPKTEYGKELLALAHKNAAEQAKPFNSITPPYEELQHFFNLSQYPYRIECYDNAHLQGEHNVGVCIVFENGLFSPKQYRTFSITSHGDDLAAFEEVLTRRFRSLTTELPNLIVIDGGRNQFKRAQRILEELNLTGITVVTIAKESGNHSKSLRQEKLFCETFPQGILLHPTSAILQFFQLLRDEAHRFAIQHYRKKHAKAVLTTKKIPGIGEVKTKRLLQKFKSWKRVFIASEEELKTVQGITAKDIQRIQEEGAKPE
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MPRTAKAPKKSTRASTKRNVKRVKASITRRQTINSLKASGEIKKGIDKKQAAKRAQRTVVSKPNKKTVEDVLPVKISRHTTSSLNQNGLLLECNGKGKSPRKSVSCPSIQRNVQKKGAQEIREQETETKRSEVNDPNDDAEQQKGAEIPTGEGQSVNISSKESGEEHRETVVNDTLVAEKKKVKVNTETVQSESYSAVVEQPNTVLVDQQDPLKHNPVNNVDFAYNNNTSGPPTPSPSDQVEAIQPTLPPVDLQDISLQTTRGNSTEEGETAESSLPNQVCQSSNDSPALENIADAPQIEETELRSTADVDTKDESIDAEMLMKKEGALSLLSLSAAIYNTTLCEMGHGPQATALLSSSTESTQSSFDSESELVLEHRTSGKSIPQVEDIQLRLLQDQQRREQNKRGHCGVCAPCQCKVNCGECRSCLNQKTDHQICRLRKCIKLRKKTLIICTGKVESEANSVNGTSSEQMEETCAAPEEEAHYIPVTHNVPPDIITPLQHGLLPEPHGKDPGTTDVLLPHSFSSTSHNGAEHIKSNAQRYVDPTETPANFHSSTINNRHAPEVVQEQMVPLKKIKLEEQQLEIDDQHSKHLETNGCYEDALSTLAAVVCFSSTDRKSLEEKLFGSQTSDVCLKTEPKEEPYQCQLNQEEPPQNDYIALSLPTVQSLVQHRNISVDQAIAIEALTQLAAIPQTVPFKTENQIQDAQQETSTYSAPSNHIPIREAKPATDVVSNKVSVISSSLHQTSVIRSSLNTPTNFTQSQRCAPPPRKLSLKDLLMASSECEKLSYTTENRRNGQALCKSDRLEGTFKMYRHGEATPIYRKKDEEEVAAQLVQLAFMIESRQAQVSENSPPNGMATQSLKYNQNYLGQHLKKQRKPKMTPSNPRMSKKKVAEIDDNHCRILLAKKTPNKKTPLKATIQKAISQHKMRFQHKRNPFLPQAQIDLKKYIAEAQHENRQLLYYNTKKEHLETFIGSGRQNGFHVKYEHGGHSLPPQNGHFYNHTNDHLGASQCPRHECEQKVSQVSKTYDVLNPGAKQQLLQTMANEPFKDLPQIPEMYHKANGFNGHQHLHTNQNGFYKVEKSGGVTVLSASSVHSENGDMVYAGEQTPTKHTINSFLESPMRFLDTPTRNLINTPSKQSMEIPSCDCVEHIIEKEEGPYYTHLGSGPNVAAVREMMETRYGEKGNAVRVEVVVYTGKEGRSSQGCPIAKWIIRRGSEQEKLLCLVRQRAGHCCQNAVIVILILAWEGIPRSVADRLYQELTQTLCKYGSPTSRRCALNEDRTCACQGLDPETCGASFSFGCSWSMYFNGCKFARSKTPRKFRLQGDSPKEEGRLEKNLQNLASDLAPVYKRLAPKAFHNQVEQEQRGQDCRLGCREGRPFSGVTACVDFCAHAHKDTHNMTNGSTVVCTLTKEDNRAVRNIPEDEQLHVLPLYKISDTDEFGKVEGQWAKIKTGALQVLSAFPREVRLLAEPVKSAHKRRLEAKRAHVEKLNSLGSKQVTPVKMKNESPKGFKQTSTENSSFSEKNSPNLSSTMRVPDIGGQYSPLHSGGSYNQSNSCRTPPVGSSFGTSTLPKFPHDPSGGTTHFNGSPPFRHGTIKQEPFRNDPVRTNPKFKSEPEEMRCFQGGAAPTPLSPPMAEGLHSRLNITAQPVTPEVAKAEEVWSDSEHNFLDKNIGGVAVAPSHGSILIECARRELHATTPILRPDRTHPTRISLVFYQHKSLNAPGHGLQQWEAKRAEKAREKEQAERLGLNNQSEPVDSDTDSENETCLDERHKFQVPTRQSLTVSRDSLVMSAPYALTHVTGPYNRWT
The following text describes a protein:
Function:
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Sequence:
MSASVTSSDGRGPASPTSSSTGASTNPATSGLAAALKGATLAFQHQQRTAAKGSDTAVPRPHGGSRVPTPGTGSVSTSTSRTVGGSNGARLAATLAAREHSPPTTSKNEASRVVTSTPSSSSSVGSAGRTNRQELHGQATGGSSQQQQQQQHVEERANDHAPSKRPAMRSRRPSLASLSSQAVDNSHSHPPTPASAKPSSEPKSVSWIAATLAATSIAPTTSLVAMFDGKQEEAETATKKKKKKKPRPASKTQHHQTLTSPSPTPSEGLSIENQCGTGGVPSVASGKSKVAPKPKPKPRRDISLSTVESIKSSTGAMGRDGKSSNQEQGETRNRNGDVRDKPSREGGKVTVTGAKDIVFEGTSERRSQQKVPATPRSVQSKQGVEVPTDKRPSTPPVSQHAQISETTIISPQPRRVVSTPRLESSPAVPKTYKTVTNPRPDNKPTIRKSSRVVSPSVDQSQTIRQSAETGLGDRHTSRNSTSSDETFVSASSSPSPRPQTPTKELERVRPRLDRANTSTSSRASRVSTPASVRSPASQTRPSPVLRPGTGLYSYSTGASPTPEMSLDSLTNAMIASNLASSRLTALTQTSLESPGLPPVPPPRRGHRHHHLPHPHLRHRTQSPPHARPLIPQRTADSLPVRTGPSRQTEHTQPASLLKTLRAPRSLSDDEDLRLQTHRHRKKHLGGKKHAHNEGARRRWRDEMTIRQRRRYEAVWASNRGLFLRPGFAFEHPENWQPLPPPDDSLGQVDLSRAWESPEADLVVNVVVRDIWSRSRLPVDELAEVWELVDRRKCGALDKQEFVVGMWLIDQRLRGRKIPTVVGEGVWESAMDRVLSVNVKAPKAHKGRTKGHLKGVF
The following text describes a protein:
Function:
Component of the tost-1 variant of the PETISCO complex which plays an essential role in embryogenesis. Within the complex acts as an adapter which binds to the complex via erh-2. Does not seem to play a role in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs). May inhibit 21U-RNA accumulation. Required for chromosome segregation and cell division in early embryos.
Subcellular Localization:
Cytoplasm. Nucleus. Note=During early embryogenesis, localizes to the nucleus at prophase of cell division, and remains in the cytosol at interphase in 2- and 4-cell embryos. Mainly localizes to the germline cytoplasm.
Sequence:
MTTAIQYQVIPLADREHSNKVASILENKYKTATNKRITLNERFGVLEKGYTIQATEPETVKNDSDVFFVVHDRNLNSKKEFVENYLAKNPIVNSPEKVFEEEDKENAPTKKAVLKPSSTDEKKLTSSDIYIQEITRSILQSV
The following text describes a protein:
Function:
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Stabilizes chromatin-associated RNAs probably by binding to them and thereby preventing their degradation. Associates with, and may be a part of, the HipHop-HOAP complex that recruits the MTV complex to form the terminin telomere-capping complex, which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion. Telomere capping is independent of the origin recognition complex (ORC).
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Chromosome. Chromosome, telomere. Note=Colocalizes with Arp6 on pericentric heterochromatin. Telomere localization is not dependent on peo/pendolino, ver/verrocchio or moi/modigliani.
Sequence:
MGKKIDNPESSAKVSDAEEEEEEYAVEKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTSTASKRKSEEPTAPSGNKSKRTTDAEQDTIPVSGSTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEMVPSSVANEKIPRMVIHFYEERLSWYSDNED
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MNHSTDTNSADMNNATALAANWYNAGALRLKAPLTELLKYWEKERLITALDRHFALEMARLHPNDAQEPLFMLLCALLSQQLSAQHTCLVLEYIVPTNPMAEPINRCQIRLSLTELIDALQHFDAIGAPNSNKPLIFEDGRLYLERYHHFETQVASALTRLSAAALSLTPSQPLASDNQSLLQLRRQLDCLFPSAAHTVEANIDWQKVATATALGNKLAVITGGPGTGKTTTVTKLLLLQQLGTPKQIRLVAPTGKAAARLSESIKASKARLEQELQQASKENPQENQVLLTALSRIPEEASTLHRLLGVIPNSAHFRHHQGNPLRLDLLIVDEASMVDLPMMYKLLSALPEHAGLILLGDQDQLASVEAGAVLADICAGLKQASTQHTEWKMRYSQAQAEQLTALTGFNLSHFIHSEPKIGDSLCMLTHSHRFKGDAGIGLLASAVNRADLAGILSVWQSGLAELTWLEHSVDHSQTQAKISEPSNNTGLKALLAQACEQYGDYLRLLQPTHATPIHTSEPFCPPSAMEAIAKFNQYRILCAMRTGDYGVEGINLAVTKALAQAKLIQPQQEFYLGRPIIIQSNDYNLGLFNGDIGLILQDEERADRLMAHFIKADGKLLKVLPARLPSHETCYAMTVHKSQGSEFNRVALVLPPAPSLVQWQLLTKELIYTAITRAKQHFSCLGTQQVFERASLQATQRASGLADRLWGDQSLSHTAAVNS
The following text describes a protein:
Function:
Plays a role in the maintenance of mitochondrial DNA.
Subcellular Localization:
Mitochondrion. Cytoplasm.
Sequence:
MSKVPINSSKLSCGGPYNQAVKSGGLIFCSGQAAVKDGNFVPGTIQEQTRLTIENLAEVLRVAGSSLEKLVKVNIFLTDIDDFAAMNEVYKEMLPDPMPARTTVAAGKIPLSSKGGKIEIECIAAE
The following text describes a protein:
Function:
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents (By similarity). Has bacteriolytic activity against Gram-positive bacterium M.luteus, and Gram-negative shrimp pathogenic bacteria V.alginolyticus, V.parahaemolyticus and V.vulnificus. May play a role in host defense.
Miscellaneous:
MISCELLANEOUS: Lysozyme C is capable of both hydrolysis and transglycosylation; it also shows a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Subcellular Localization:
Secreted.
Sequence:
MRVLPLALLVGLLAVSDAKVLGKCEFARLLETRYNLSRNDIKNWVCIAEFESSFNTAATNRNRNRSTDYGIFQINNKYWCGSDYGKNVCGIPCSDLMSDDITAALRCAETVRRATERYRGRGKGYTAWVAYNSKCKKRDLDQYMAECWSRGSNSIFPF
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MDGDNQTPLTKSPERSLWSMDKLIETLSILTAPEKASSMSLMGKGGIFDLATSFNVWSTNLFLSSNLRPDQGAAIVFNFLISRIFKEDYVTGLIRARAASSSPALLGESVDKELKIREVLFGCSENPEHHTPLSQSPCLDLNDCSKFYYPESYIHSELFMKLHGEELPLSICGKVLNSHLGFKCQYCTTDKSSVMCLECFDESKHVGHEYRCFFSTGLCDCGSVVSTGKTGVCARHLGDNYSKNALSVYTGIVGSSCDLAMLCNVAVFLSVALLQSIIFPIEAFLTNLTAIDAGALGDSPAISIASAKRSDLECSVQSLVNNVFHHLFINVKIDGFWRILSKVLTIPVTNSTTVGDILAYDPVHQRYYRDVMAFAQKLVSSRRSLIAGISKLRSNALSLSMLMEDLAEGLVLSDIIFSLSLFKVILDKEKLCLSRTTTASGLEHDQRWLTVDSPALNDLLKFIVDGLIFEPIYRVFLCNIYHWYYPYLFIGALNNDISEGPWDLAADKLAHAFTHDPPMFCKYKPRFLQIQRAFAYGPISFSVVNEAIKQLSLIYNDKYAETFDAAYLHSYLLENFKLPHRVIPQDNVWTRAPVQIYTEFNPVDEACHLIAGYILSTVYLSLSISFVPNYLHRERALLFREYIFKTLHDNYIDCGQLGAGMASTAAENGSLTDTIFNSIFRGLDESLPYMCCIPNGFLPISNLDNGEYGDDTRFAIEAHRSFFDVYLSSCIGVHHPIAYSGKMSNFTQSSFFHPLPAMALLAVISSLTTVDALQVMYGNHLEMDTEFGTTRYRNVLTYSDFTTYFTYGAWFAFTHGPFYNDNPMFPNDTISRKHCDAFKLAELRGKFGRNDSEIQTGNAYILSFLHLLCMFILTINNSEALSFEPLFQGAKEIEREQASVEALKTGSSTVEKFDYHELDLEVHIYHPIFLPLHYILGYTLGAVSTRNAFGISSVAVSDVIAQTIDRIISLNNYVEEPVSILKVQLFNLCCHYNNVLKGSSIFTEYLRASCLTPEEQKLAVEIGICDLAHDEEYVSPCLVRPRHTVWNQYQNIFWNEACLPGLNVRTRIALELVLLPFKTLIAIALNFSEMFVRSGMAQKYIFYVLMNSSRACSADLLSMGYACQSVLRFLYDQQESCPGGLEAFFFILFNLAERRIALEKDLAKVTNARALILKTAISFLCFDYSPRTVENQLALLYLPRLVDASPDDTVVSIVDSCMRLTFWREPTVMGTLAQVCDIIYPATDALNTDVYSITECAAYYRLNKKGWAYTSIYSPTVTGIDYVDAWERYCRETNQPQEDCSTDRRVPVPVPQCVAGLTALSNDVEKLDGDYADLISIHGNGLSPALTAAVMRIPCVGLYICQVFADAVLSHFTRTDVESSLRPTVVLCLCNTFFLLHHYTIRDVPEHAGAGAPSLVDPAVKKAVTETYDALYTYIKSVLDSGISHCFFNDSIMEFLRTVVYREKFQPEVSLVDSELSTTKPITKKPKRKLAFLKEKLGPSKSGILMSIDDLTSLETLTSISHEPAKNSNLDTQQFFPASVGKVLYEVVQSIIVNNDTQCYNCRLFDVPELPICQPVAFVPNSLNKLYANILKQSHKGDKEFSNILEHPWINPARQLFDKDLVLIAYPPLPADQHLEEIAHHTNHIKYKDAFRGVIFSKSTTLSIWNAIPLVHSLSDKLYDVPTVKYFIRVAGCKHFSHSSCLSFNKITSLPKTCSICRRFYNTCLPVVTAYKSQSSSPEGIAKLKEQLLEEFRLQSLAMAMCMSVLIYHGNATIALSTQQLYAEFVSASSFSLTESPTAQLLFPRRSARHQETSLAHSQNLIYSAWYIMFSDLILYNTFLTLHGFSIGLQSKLFTDSRLMTMLGSNLSSLGSVVLIAQITLSFLINRYGPNLCTIAFGPARMRCTHILQQELFMELHRSFVKVLETLIGILKDTERTPKTKNMYGFVDNISAESGSTEKVVYWAQGNSMTLTDREISQAILDQNDGRRELSLKAQCIIPSIYNFSQVNCYLGIFLQISNRIVGVIGFPLFMHYLGQLLACFDLLHPGEDVFLPFTNLYENPAVVFVALFLSYEVGLFSITEPSVLISEQQYHNLHSQYNSCPSDALSYQSYCQREALMARSLIVDHAHISMRHSSDYDLALFAESVAEALNELTTKLGYDEEQTPWNAGLIIELFTEINDTLGLAYQGWKTTNYSQDEILSNICATMPRFEHRKFVILAKNALTAARSIVTPGELYLFVHAFKASHVLSAVGTFFGNTASEHNKVISSISSLEGYSLHARRFCMTHLRSFVDSRHSFTVAAPPSSYGLYSMIAGRDSLRITPLDYSRRYLYKVFPFSYTAVKALKKYITDKHACPYCKYTPERSKNDEINLIVCMMCGQCFCNFCGHTHTNINIQETPDYLDIDRFLALHDSLDVWTPVIDISAKALHKYSIFISILHHSAACILPAVFYLPAQNKILCLNGTGVIWTQPAPMLSKYGDPDVNMRDGIPVRLAEEQVGRLFATVLINGLLDLPVEHNGFFSIPYYLG
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine; Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.
Sequence:
MKIIFNKKILSADTPIIYSNDRGFLFGDGLFETIKAEKNELLFFAEHYNRLATSAKKLFIPLNFSLLELKTQCESLLEINKLDEAAVRITLTRGSSERGIAIESAVSPNLLITTIPYKKQADIYPTLCITAIRRNEYSPLSQLKTLNFLEPILTRQQAIKNGSAEGVMLNTKGAVTETSVGNLFAVIHQKIFTPKIEDGLLPGIVRQIVIDIATKTDIPIKEKTLSPEDLLEADEIFHTNSLIEIQSFAKINERPLATGEQALLTRKILETYEWYKNKRKK
The following text describes a protein:
Function:
Involved in the regulation of inflorescence branch growth angle. Promotes horizontal inflorescence branch growth.
Sequence:
MTIFNWVQKKLHQNVIKEIDGVRKNEKKKRNEGISEIEKNTKAILDQVGLVDALDNWFDGVLTIGTFGFDTLNFKEEDEMDDDECGSGDLDYVVIDGSIIKNVDQESDPLISVENKFYDHHEDVGNLYVQADTDHFGSIKTAETPAVTAAAEAEIEPQKKRTTLAELFMEDHDKGYDTWHCKKPNNPNLDGEEVKYYKQNGSKLSKRFSFVKKKLVMSKSKEEENDLRPIKKMRQMIKRMLKKKIHPDVDATKALKKDVPYKPTRNCEALESHYLLKIQDCVA
The following text describes a protein:
Function:
Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 (By similarity). Seem to be non-essential for normal development and function of the central nervous system.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane.
Sequence:
MLTDFLQAPVMAPWSPFSLHLLLLFLPLLPLTRVHRFSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRTQELVACGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVRQLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLYSYVEMPLTCHGQGLIQAAFLTPDTLLGAFSAGTSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEATVEYGVTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQQVGPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVAACPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGRAAQPNHWLWSYEDNHCPYIQSLLPAQHPRQEQGQIILSVPRLPTLAMDEYFHCAFGGYNSLAQVEEPHVVCTTPPQDQMPPNPPGSDHVTLPLALMFEDVVLTATTFSFYDCSAVQALEVAAPCRACVSSLWRCHWCPQSSHCIYGEHCPEGEKAVYSAQEVDILVRGPEACPQVEGLASPQLVPVGWESHVTLHIQNLHYFQGLPALYHCWLELPGKLQKLPASLEETSRDSGLIHCQAQQFYPSMSQWELPVPIYVTRGEIQRLDNAGDLHVTLYDCAMGHPDCSHCQAANGSLSCLWCGDGQPACRYGPLCPPGAVEQLCPIPSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPNGTAGPVQVAIKSRPPGISTQNFTYQDPVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISVFVGDQPCPIQEPVCPEAIICHTMPQTEPGEAVVLIVFGHVERKLLTTPFRYTANPQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEPKVKALGVQAQDANPRRSCGAPAADPQACIHLESGLLQCSTLCSVNSSSLLLCHSPAVPDGALPKRVFFALDNMQVDFASASGGQGFLYQPNPRLAPLSHEGITHPYHLKPGHVLDVEGEGLNLGISKEEVQVHIGDGECLVKTLTLTHLYCEPPPQAPQPTNGSGTLPQFVVQMGNLRLALGPVQYEAESMMSTFPVEAQLGLGMGAAVLIAAVLLLTLMYRHKSKKALRDYQKVLVQLENLETGVGDQCRKEFTDLMTEMTDLTSDLEASGIPFLDYRTYAERAFFPGHVGCPLQPGLEGLGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVDKGPVDAVTGKAKRTLNDSHLLREDVEFQPLTLMALVGPEADRAAGNSGVHRVPARVLDTDTITQVKEKVLDQIYKGTPFSQRPSVHSLDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDGATVVLIPQVHNGGTVSQSLGQTGCPSGENTPMLEDGEEGGVRLWHLVKATEEAEGAKVRRSSLRDRERERSRAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSMNRPVPIAVKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNVLKNPQLIFDVQVSDNEDAILAVIAQTFIDSCMVSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAELSGNYSSAPHCLEALRELYNHIHRYYDQIISALEEDPVAQKMQLACRLQQVAALVEYKVTDL
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MALYEHVFLARQDASPQQVEELTAQMTGIVEGLGGKVTKTENWGVRSLTYRMNKNRKAHFVLLNIDAPSAAIAEIERQERISEDVIRYLSVRVEELEEGPSAMMRKADRDRERDDRGGGFRGEREGGFRGDREGGFRGGDRDGGGFRGDRGPRRPREEAETATDGE
The following text describes a protein:
Function:
Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries. May be involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MILVLIVERYSKFEFLKVELIEIRVKALEGVHSDYGDTYEDPKLPPIPPLAGPAPGAIPSMSLQRNLPMSNNHMPGSGAPNLPVSSSYNQVNVDSSGSQYQTQINNHTFPSGFSLGQKADASTYWREFTSPGENLHASDFGSISVVKTSSPGADGLLVSAHDAKSSPIAVSPAANLPTIVALESSSLSGNVSSPMIGTVEMKNSSEPALPAVANSEKIGIAVTLGNSVAPPVHVFRFICYKFASGLCCFLFGIQFFCSFETTTTQVTVVYGDGFSSKNRENVKKDVVITEIGGTTPSDEKIVELGPLVYESKAEEKSTFKTLLESANIGSDCMWNQAMRAVINDRRYGALKSLCEQKQAFNEEHAKALEEQKRNRVEYLEFLKSFNFIKASSQWWKVQDRLETDERCSRLEKINRLEIFQRMVVVEVVTPVTVVVMVSEECVKVDDVLVVVSDVWKLMMCRWLLVVVVVLIDELVGSRDQLVAVDGGDVGGRGVHGSIWVGVVAAGSVVGSDVGCDGGSGWWWCQIGLTSAWTLDDFKVAIAKYISSPPMSDTNLKVLHKMSGLSAKALVVLPCYVSLEVGQFVIAKLATRRKLLHRRNGRTGNPSSEIGK
The following text describes a protein:
Function:
Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. Possesses ATPase activity.
Miscellaneous:
MISCELLANEOUS: Present with 1620 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEGQKSNASWESSIIEGQLSKNLARYTLLLDKLSTLSQIDKLSEVIANDYAKQSKQLNAFVQQSQSSLNKESRKLELQRTNLTTTLTQFHETVATISSSNARAKAIHDDIETVDQERALVNKTLQFVKDVRTLKNNISLAHSALETKDYLVAATAINEIRSLPDKKLIVSEFAKKVVPSSEIPEEPAILIKNWCKELTSLFQEQFMEATRTQDIKELTLMFKMFPMIGQDVLGLDLYSKYVCDIIADESRKIMSNSMENSTKFQGFFSQVLLHLFKIVSTIINDHSKVIATCYGKKHMVHVMEKVEKEADLQASLILDIFMETRKIERTIHDINEWEHSQKNEDVNIDSNQSDIETDGETEKSSIISIHDLALLIMEFSQILQNWSMYSRFYSVKWNEFSDLHPHVLQPPPPIADGKFALKLKQDKVFDEFQVFVLNHLQRSFRNSISLEELPSLNDLITAVPLNDHDNISYPVTSVLDDLILLVRKNLISVVNTGQFKLLASFLNELVKFFQNRFLVKFMQNKFKLLQSKLASNVSLKRYIPKGEEQSATSRSVSPPANKFSPLSRFTFRGAAASALTNIQSNLQAVVAEDEDSILALHHYLIYLNTLYLSKVYVHRLLSIEILEDDSQRILRDNFPFDNDAAQLQNLIINSEKLVLEQTDKLSKWAVKYLFQNILQNRVRNLLGTVFVNSASSNSSTSNQKNVSRDYSAGSNQKNYITSIEDFEDLSQINSFNSKWNQLIIPYKNILHNEAYAELLSVIVDYIVTTLEQRIWTLEFNELGVTKLDRELSLFIGNMCGLNYNLREKFLKLTQIVLLLGLDDDNFDLTTGDIKDDFNGTFDWVINSQERIKARNMKIDRTQ
The following text describes a protein:
Function:
Involved in the production of sphingolipid metabolites. Active on sphingosine, phytosphingosine (PHS, 4-hydroxysphinganine), D-erythro-dihydrosphingosine, D-erythro-sphingosine and trans-4, trans-8-sphingadienine, an LCB found exclusively in plants, but not on N-acetyl-dihydrosphingosine (C2-dihydroceramide) and D-threo-dihydrosphingosine.
Sequence:
MQKSGVNRNPSLKVAIPQAQQSLRRLGFCSQIATGGSQQSSPIVFPEKRNKKVKASSRRGEVTNDPQVKPKPDEHRIDIGGGDEKSDLLGSLVYAGKLVLDKRKSASGKDATEIQQPAATDISIKKAVDAKLTSSALVWGSDMLQLNDVVSVTYNVGLRHFTVHAYPIGKGSCGLSCFTKPKRSRKDFRFVAPTVEEAVQWVASFGDQQCFINCLPHPLVAKKQASSELFSVPIDTPPELVFRCKSAPKMLVILNPRSGHGRSIKVFHNVVEPIFKLAGIKMEVVKTTKAGHARELASTVDINLCSDGIICVGGDGIINEVLNGLLTRSNPKEGVSIPIGIVPAGSDNSLVWTVLGVRDPISAALSIVKGGLTATDVFAVEWIHTGIIHFGMTVSYYGFVSDVLELSEKYQKRFGPLRYFVAGFLKFMCLPKYSYEVEYLPAQKEDAEGKIRLEKEAVDMQDLYTDVMRRSSREGFPRASSLSSIDSIMTPSVGELDTCSSTHASTEPSEYVRGIDPKMKRLSSGRRDVTAEPEVIHPQAQSTTPNWPRTRSKSRMDKGWMGLTSVQDPPTRCSWGNTGGQDREDISSTVSDPGPIWDAGPKWDTEPSAWDVENSIELPGPPEDIETGLRKQSITPIFEDKWVSRKGHFLGIMVCNHACRTVQSSQVVAPNSEHDDGTMDMLLVHGCGRLRLLRFFILLQTGRHLSLPYVECVKVKSVKIKAGKNTHDSCGIDGELFALHGEVISTMLPEQCRLIGNAPGRHS
The following text describes a protein:
Function:
Required for the methylation of the wobble bases at position 34 in tRNA. Appears to have a role in stress-response.
Miscellaneous:
MISCELLANEOUS: Present with 2360 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEINQAAEKEQEYVHKVYNEIAPHFSQTRYKPWPIVTQFLKTRPMGSIGIDVGCGNGKYLGVNPDIYIIGSDRSDGLIECARGINPSYNLLVADGLNLPHKNETFDFAISIAVVHHWSTRERRVEVIRHVLSKLRQGGQALIYCWALEQGSSRRGYHEGMEQDVFVPWVLPKSKSKPKTKSTPPAKVKTRPKPNLMNIPPKERSEYLQRWKEEQQRSKSLDDNDEKQQQDQEQEREEVKYRYYHLYREGELAEDCRQAGAAVHSEGFERDNWWVVAQKR
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.
Miscellaneous:
MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
Sequence:
MNHSEVKTGLIVTAKQTYYPIELSNAELLTHYETIQEYHEEISQNVLVQSSKTKPDIKLIDQQPEMNPHQTREAIVTFLYQLSVMTRVSNGIFFHAVRFYDRYCSKRVVLKDQAKLVVGTCLWLAAKTWGGCNHIINNVSIPTGGRFYGPNPRARIPRLSELVHYCGGSDLFDESMFIQMERHILDTLNWDVYEPMINDYILNVDENCLIQYELYKNQLQNNNSNGKEWSCKRKSQSSDDSDATVEEHISSSPQSTGLDGDTTTMDEDEELNSKIKLINLKRFLIDLSCWQYNLLKFELYEICNGMFSIINKFTNQDQGPFLSMPIGNDINSNTQTQVFSIIINGIVNSPPSLVEVYKEQYGIVPFILQVKDYNLELQKKLQLASTIDLTRKIAVNSRYFDQNASSSSVSSPSTYSSGTNYTPMRNFSAQSDNSVFSTTNIDHSSPITPHMYTFNQFKNESACDSAISVSSLPNQTQNGNMPLSSNYQNMMLEERNKENRIPNSSSAEIPQRAKFMTTGIFQNTGELTNRASSISLSLRNHNSSQL
The following text describes a protein:
Function:
Cell wall formation (Probable). Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Subcellular Localization:
Cytoplasm.
Sequence:
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MAPSLSGQSCNMKTAVLAGSRAKVELFQVLYFNRPARRDMTEWTLLKRLLDAVHQHSTMIGRLWLTIMVIFRLLIVAVATEDVYTDEQEMFVCNTLQPGCPNVCYDAFAPISQPRFWVFQIITVSTPSLCFIIYTWHNLSKQPEGEQIKEALERSCDSESCSIKSHKHINPSLEGVTNQKPSQASKTSSGVLSKYYIFHVCFRTILEVAFVVAQWLLFGFRVPAHFVCTSSPCMQSVDCYVSRPTEKTVFLIFMFCVGVFCIFLNFLELNHLAWKMIKRSVLVKDGSWNGYGAINQDSQSIASLTFRDVTSTTSLPTLDLVVDHQPDWTCAANCSTKKDNRGTQSKPKTNRKAKQRSTEVWI