lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Inhibitor of protein-phosphatase 1 (PP1). Binds to and inhibits PP1 activity. Required for early embryogenesis progression.
Sequence:
MSTATRPSSSATTSVILENPVSQSQPTERLVLRLNRKKKKVSWKDGTVDNEFMQKKSSKKCCIFHKQKPFDEDDSEEEDDNNHHCDHNHEHSESGEASSSNDSKAVD
The following text describes a protein:
Function:
Promotes cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDLIREQGALAGVHLSLWVPGPVAPVNPAPRGAVGDSRPDPRMEAVRDEHALGGGMEADEPASPQEPPSPPLPPSPPSPAVPEPPEVPVPEPPTEASARQLLLEAWGPPGAGLELPPRLTWKLLFLRRPLYRNLLRSPNPEGAAGPERGGRPVPVFFPAWPTQTVRLFFFPSISLFSLPSLSLHPSLSLSLCLCLFASLFVPSPAHLRLSLCLSPSLCLCLTLYPPLSLPPSAYILCLFPSVPLCLSAWVSPHALVLPLPLRSPPSPLRTFSGLSRALTHCPCPAGLAWLARPRFPPFLGSWAGREGEDVEGAASPAWGPTNLLVPGINIYEPAPSTGPTQQPLETLGNFRGWTIRTEMLQQDLSWTVKQQCVDLLAQGLWEELLDDEQPDITVMDWFEDSRLDVCVYELHVWLLAADRHTVIAQHHVAPRTSGRGPPGRWVQVSHVFRQYGPGVRFVHFLHKTKNRIEPGGLRRTRVTDSSVSVQLKE
The following text describes a protein:
Function:
Involved in the assembly of an N-linked disaccharide that decorates the S-layer glycoprotein and flagellins. AglK initiates N-linked glycosylation through the formation of alpha-linked dolichyl monophosphate N-acetylglucosamine. It catalyzes the transfer of GlcNAc from the donor substrate UDP-GlcNAc to dolichyl phosphate C55 (Dol-P) to yield Dol-P-GlcNAc. AglK reaction proceeds with retention of stereochemistry. The reaction is specific for UDP-GlcNAc. AglK shows a stronger preference for short dolichol (C55-60 Dol-P) substrates compared with the longer (C85-105 Dol-P).
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MADKLIYLIIPAYNEEKMIKNVVNNLQNHNYDNIIIVDDGSKDNTYKIMKELEEESKQNNNNNNNNNNNKVIAIKHEQNKGVGGATITGLKKAYELGADIAVTFDADGQHAPDDIAKVIQPIINDSKEYVVGSRIKNPKEFKNMPLTKKVGNLGLSFITFLLGGYYVTDSQSGLRAFSKSALKVLSEQLRAKRYETCSEALIIAKKNKLNIGEVPIKTIYTEYSMARGTNVMIGFKIFYRLLMLKMGKVLD
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLGKADRPDASSSKMARFRHRPHANPLADNDFQFPCTEPDEFPFDLYYPTWTSQRSTDAREYHFDIVDIGCGYGDFVRNVSLAFPDLLVIGLELRDIPVVLGQQALLNGRSAGQNENAAIIRCNIMKHLPRLLARQSVRYLTVMFPDPQFKASHARRRVISPQLLSEYAYYLKSGGFLFVCSDLQDLYLYMCSTIAGHPFFCELQHEEGADDNDGDTRVVKTILKLMDKTADAERHMRKDADKTVYKAVFRCTKPHCM
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Miscellaneous:
MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTEWQAVVLGIVEGISEFLPISSTGHLILTAHILGIKHTDFVKSFEISIQLGSILAVVVLYFNRLIRDYEIWKRIIAAFIPTGIIGFLLYKLIKGFLIGNDLVVVVSLILGGIILIFADTYCEKFCYLGDVRELPLRKAFMIGVFQSIAVIPGVSRSGSTIIGGMLMGLNRKVAAEFSFLLAIPTMFAATTYDLIKSGGSFNAQEWNILIIGFITSFITALIVVKWFLNFLKSHSLKIFGFYRILIGLVYAAFFLF
The following text describes a protein:
Function:
Involved in indole glucosinolate biosynthesis. Catalyzes methoxylation reactions of the glucosinolate indole ring. Converts the hydroxy intermediates 4-hydroxy-indol-3-yl-methylglucosinolate (4OH-I3M) and 1-hydroxy-indol-3-yl-methylglucosinolate (1OH-I3M) to 4-methoxy-indol-3-yl-methylglucosinolate (4MO-I3M) and 1-methoxy-indol-3-yl-methylglucosinolate(1MO-I3M), respectively.
Sequence:
MGYLFEETLSSNPKTPIVVDDDNELGLMAVRLANAAAFPMVLKASLELGVFDTLYAEASRTDSFLSPSEIASKLPTTPRNPGAPVLLDRMLRLLASYSMVKCEKVSVGKEQRVYRAEPICRFFLKNNIQDIGSLASQVIVNFDSVFLNTWAQLKDVVLEGGDAFGRAHGGMKLFDYMGTDERFSKLFNQTGFTIAVVKKALEVYQGFKGVNVLVDVGGGVGNTLGVVTSKYPNIKGINFDLTCALAQAPTYPGVEHVAGDMFVDVPTGNAMILKRILHDWTDEDCVKILKNCWKSLPQNGKVVVIELVTPDEAENGDINANIAFDMDMLMFTQCSGGKERSRAEFEALAAASGFSHCQFVCQAYHCWIIEFCK
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
Sequence:
MGRITSSRSQLIGDPRHHSLLASKFINCLMLDGKKTTAQRVFYDALEEIGKRHEGEETPIEVFEAALENIKPYIEVRSKRVGGASYQVPMQVNKARQQSLAIRWILAAVRDKKGRPMALKLADELLAGFKKEGAAYTKRENTHRMADANKAFAHFAW
The following text describes a protein:
Function:
Involved in degradation of pectin, which causes soft-rod disease in plants.
Subcellular Localization:
Periplasm.
Sequence:
MAKGKKLSFSFHTYQDSVTGTEVVRLTPPDVICHRNYFYQKCFSNDGSKLLFGGAFDGPWNYYLLDLKTQQATQLTEGTGDNTFGGFLSPDDDALYYVKNVRNLMRVDLNTLEETNIYQVPDDWVGYGTWVANSDCTKMVGIEIKKEDWKPLTDWKKFQEFYFTNPCCRLIRIDLKTGEATTILKENQWLGHPIYRPGDDNTVAFCHEGPHDLVDARMWFINEDGSNMRKVKEHAPGESCTHEFWVPNGSALAYVSYLKGSTNRFICSVDPVTLENRQLTEMPPCSHLMSNYDGTLMVGDGCNAPVDVKDDGGYKIENDPFLYVFNMKTGKHFQVAQHNTSWEVLEGDRQVTHPHPSFTPDDKHILFTSDVDGKPALYLAKVPDSVWQ
The following text describes a protein:
Function:
Vacuolar Fe(2+) uptake transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MLICKISEKGSPATGVDPQSITLFSPRSPALKVYAENTAKAKRETICKEEALPSPYKAAAASALAFLCGSLFPLLPAIFIAQNTLKVAIVVVVASIALALFGGIGAHLGGSPVKVSATRVLVGGWIAMGITYGLLKPFDKDDDK
The following text describes a protein:
Function:
Participates in nucleolar liquid-liquid phase separation (LLPS) through its N-terminal intrinsically disordered region (IDR). May be involved in ATE1-mediated N-terminal arginylation.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleoplasm, a significant portion localizes to the nucleolus.
Domain:
The N-terminal intrinsically disordered region (IDR) facilitates its liquid-liquid phase separation (LLPS) in the nucleolus. In the IDR, the lysine-rich domain mediates self-association and targeting to the nucleolus; LIAT1 proteins of some primates, from macaques to humans, contain tandem repeats of a 10-residue sequence, whereas LIAT1 proteins of other mammals contain a single copy of this motif. Quantities of these repeats are, in general, different in LIAT1 of different primates. For example, there are 1, 4, 13, 13, 17, and 17 repeats in the gibbon, gorilla, orangutan, bonobo, neanderthal, and human LIAT1, respectively.
Sequence:
MAGRGGTGAAEYGEEGEEEEEEEAREGGAEGSPGSKLPPIVGTASELAKRKVKKKKKKKKTKGSGKGDADKHHSRGRKNQPLSSSFHDILNPHKDHGLRAEPRDKEENRQTLPYSYSINHPCFAEIEDTLSSQINESLRWDGILTDPEAEKERIRIYKLNRRKRYRLMALKCFHSDPCVEESVENLPYLSDKDCSPCSKQPSSKGDHAHSYFEASKLLHPELATTVAE
The following text describes a protein:
Function:
Condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Sequence:
MTKPENIGIHGIEVYFPSTYVAQEDLEKFDGVSQGKYTLGLGQTNMAFCGDREDIYSLSLNAVNNLMDKFNVDPNSIGRLEVGTETVIDKSKSVKTVLMDLFAKHGNTSIDGIDTINACYGGTSALHNALQWMESSYWDGRNAIVVAGDIAVYEKGPARPTGGAGVVAMLIGPNAPITFESGLRGVHMENVYDFYKPDMDSEYPRVDGKLSISCYFRAIDNCYNRYAKAFEKKYGKSFSLDQVDFALFHSPYNKLVQKSFGRMLYNDFLNNPNDSRYASLEAYKNVKPEDTYFDSVLEKALSAITKNDYATKVAPTTLLAKQLGNTYCGSTYSGLLSLLDEKSNDLVGKRVLTFSYGSGLAASAFSFKVEKPINHIVEKVDLKNRLAKRVRVEPEIFTEKLSLRETRHNLKNYVPSDETTNMFPGSFYLSSVDNAGIRKYDRTYSTSAVLGAFQRRQQISQSTIKSLNLFRATKSVLSILKK
The following text describes a protein:
Function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis; Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has very weak wax synthase activity, incorporating palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
Sequence:
MPRGCAGARFACNACLNFLAGLGISEPISPGWAAMERLSGLDAFFLYMETPSQPLNVCCVLELDTSTMPGGYTYGRFHAALEKYVKAAPEFRMKLADTELNLDHPVWVDDDNFQIRHHLRRVAMPAPGGRRELAEICGYIAGLPLDRDRPLWEMWVIEGGARSDTVAVMLKVHHAVVDGVAGANLLSHLCSLQPDAPAPQPVRGTGGGNVLQIAASGLEGFASRPVRLATVVPATVLTLVRTLLRAREGRTMAAPFSAPPTPFNGPLGRLRNIAYTQLDMRDVKRVKDRFGVTINDVVVALCAGALRRFLLEHGVLPEAPLVATVPVSVHDKSDRPGRNQATWMFCRVPSQISDPAQRIRTIAAGNTVAKDHAAAIGPTLLHDWIQFGGSTMFGAAMRILPHISITHSPAYNLILSNVPGPQAQLYFLGCRMDSMFPLGPLLGNAGLNITVMSLNGELGVGIVSCPDLLPDLWGVADGFPEALKELLECSDDQPEGSNHQDS
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEKIYSGKVKNRRKSYVDVTKLPDDDVTDASDAGDDVEDESLLHLDLHQISIDIDQFTDELSTVDEKEISPEIPDTVNTFVGIIESRINKRYNSIQPGSRFANLTGEDEFFIEAIKRLSKLKIVLGEFPNSSSFNKVSKVLQQAMVLMEEEFGALLQDWTTSTEPISKSKSSSSKSDPLPTLTPETSYSNNEQDFPGYTEENITLMNKIASLMIPAGYQYECCQVYSTMRKDGINEQVKRFEFEKFNVEEVPKLKWVSLEPDITRWIKLANHCSSVLFPAERKLGETVFSDHLKVFTTLFINLLRGVTTLLVESVTVVATAKPKAKRLLKFLEMYVAIRDLGDSIDDSDSSNVKLEESCNLTSEIASATYIIGQVVLNMFNDLKSSIKNDANKTPIQGGGVHPTTRYVMNYIKCAFDDYQHVLEYVFREHTKPEDDDTEEESSILSKQLLSVIQLLDSNLETKSALYKDASLGYIFLMNNDRFILQTVKEMNGVLGDNWCRRKSSDVRNYHKSYQRETWNRLLQCLTQEGVQVKGKPNRRILKERFKNFNAMFDEIYKTQSTWVVSDDQLLSEIRVSITAVVSPAYRSFVGRYKPQFEGAKSIDKYIKYQPEDVEAMIETLFEGTEKVDNQMNSIQAVSTVKQTTGAFKNLLKSYKNVGLM
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGDVEHLETQSMAPVEFIVDQARVIKAIKLELEAAGAFRGIETNGGSKIVRSSLDVSADTAARICTTYQVSSREYSAGAPRVPRTLEGFAESYLHAQGFSEVETAALLRAMPQRYTLYPPLVLFSHSGARSFEHDAWGAAFARMDKDAFFAAMLASGCFPTGYTHVAANRPIVATDAMRRPFNIAPLYGELLAQGDAAGAQLWEQPTAADFARSVWCSVVQNGIRQTWSPVFTMFSRGNIKEKKRILDTYPDVAGRDVVDLYAGIGYFTLSYLARGARSVYCFELNPWSFEGLRRGLAVNAYPGSCYAYNESNESAPARLAGRDLDVRHINLGLLPSSRPGWGIAMGLALAHGCRPITTLHIHENAAASELHALADTVADELRALAATCSPGLHVRPRHLEKIKTFAPDVWHVCLDVDVSRSAE
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDVMPLLLLVAGSAAVAAAGRRVPVPVPLLLVAAGLAVSYVPGVPDYTLDPHIVLPLLLPPLLYTAATDSSYLDLRAQARPVALLSVGYVLFATFVVGCAAYLIVPGLPLTAALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLVNDATAITAFKVALAAAVGEGATWAGGIGEFLIAAVGGVGVGLVLMVPLHWLRTHLTEALLQNTLSLLIPFVAYAVAEQVQASGVLAVVVVALYLGHRAWEVDFATRLQEEAVWKMVAFVLESAVFALIGLQLPVVLKGLGEYEGADAAWYALAVFLVVAVARFVWVYPATYLPRLSARVRAREGELSWKGPFVIGWAGMRGVVSLAIAFSIPLTVHGGEPFPERNLILFLTFTTVIGTLVVQGVSLPPLIRLLKFPAHDVQAETLAEANAQAQASRVAELRLDDLLADERNALPAPLADRLRMVLERRRNAVWERLGQVNPVTGETVDDTYRRLSREMISAEREVFVRLRDGRYIDDEMLRTLLRRLDLEEAAAYREAT
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MFMINILMLIIPILLAGAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSTSMFILAPILALGLALTMWIPLPMPHPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLSTLIITQEQTWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNMFTAILFLGTSHNPHMPELYTINFIIKSLLLTMLFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT
The following text describes a protein:
Function:
Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-directed RNA polymerase complex (RDRC) which is involved in the generation of small interfering RNAs (siRNAs) and mediate their association with the RNA-induced transcriptional silencing (RITS) complex. RITS acts as a priming complex for dsRNA synthesis at the site of non-coding centromeric RNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEQVQDEIWKLSTLDAWEMVNKNTEVVFDEIPEPETLSEMKRHPLYSNIFNADNNTTSFTEQIETSETSKTQDSEGNKVDKNLKENKSIRRKRSIDNDYELSNVKRNDITSGKNREFENEHHPASDTSSWRELPSIPTLEELTSKSVELPSNNIYGGYKSFEDYLSIHYRLLREDAVSPLRESVLRYKVNPNYITGSSLAVYDHVRIDGYTISSSVIAAKLSFSVRAKKKIKWATSRRLISGSLVLLSNDDFQTFRIGTVCARPLSGLNKHPHEIDVKFEDISISLDPREEYVMIEATSGYWEAYKHVLRSLQRLSASTFPMKDYLVHCKSNQETAKHIQNNPRIRINSILKNNSQKIVNALEPFGPGEYILDSSQLKAYQSMLTKRLSIIQGPPGTGKSFVTLKAIETLLENTHSHVLPILVACQTNHAVDQILIRLLHQGASVMRLGSRTKDPEIAAVTIFQKAKHTKHSFKAAYNEIRHKKQRLIKQITNIMHNFNLEFVTLSYLHSKGIITTSQLESLRNNTEWISSVAENGEKTEEELISIWLGDAKVELITPSEITDGFEEELQIDPEKLEEIQKEAEDSGALMEEELRGKFINLRCKYLFSKLTTLHEKEIDTLLTIPNIWDIPEYSRGIIYCRWLESAYAAAEKELNRLYRFYLKVDRERIGFSNKRAAILLRGANVIGMTTTGLNKYRDILERINPKICFIEEAADVLEGPIIPAVFPSLEQLVLIGDHKQLRPGCSTYALRQDPFNLSISMFERLVENDMEYTRLTMQRRMHPQIRRLVSSVYEDLSDYEITKYWPSIPGMGEIRRFFLTHSRIEDNDGFASKINLFEAQMLVQFAVYLINNGVEPQKITCLTFYAAQKDLIERLLSESLNREKHFIKVATVDGYQGEENDVVLLSLVRNNDRTEVGFLSSPHRVCVSLSRARRGLFIFGNAQLVAESNPLWWDAINTLMNDETIQGLGDHLPLFTKDGTIYVNDPVELLDVNMRLTRK
The following text describes a protein:
Function:
Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Note=Transcytoses across the cytoplasm.
Domain:
Ig-like V-type domain mediates binding to lymphocyte.
Sequence:
MRPLLMLWGCLVLPGYGSVVNPKEISGFEGDTVSLQCTYEEELKKHQKYWCREAGLFISRCTGTVFSGEYGQEGRVSVHDNPRENRFTVILRNLTLKDRGKYLCGVKRLGFDKTMSVSLLVFPGTSLHPATSPPAGISQPATQLDSTSTEDTSFVPSSSSKSRVSIPLIRILAPVLVLLALLLATGLAALGNYMFQRREKAQLASETQKKDKVHLSHLTSEDDEASWRDPKGDMTPASTLPMSGDEPGFSKFSSV
The following text describes a protein:
Function:
May play an important role during development.
Sequence:
MKCQLLFVATVCLASVWALPVPDEEVAIQPDSGAKAELLTKTVLPTAVEPAPLKPEAEKPAETKTIEAKAAVPEQPDVNANPSPSTPAAEPAKEINSVELKSSAPDVETAPAIPEKKTLPEEAKPAQENAPVEAEKKQEKTARTEAEPTVEAQPQATKAIEQAPEAPAANAEVQKQVVDEVKPQEPKIDAKSAEEPAIPAVVAAEKETPVPEQPARQERINEIEQKDAKKDAAVAEEPAKAAEATPTAAPEAATKSDSNIQVIAPEKKSIESSPAAAAASPAAQAAQAKSGEAPKPVDQQKSTETVAESAPVLKTNAPLAPAGATKVTEAVKEQEKEQPAADTAAKALPEQKKTEETAAPAGAPEPTAAVAPAAVPEAKKIDEAPAAETVVKGEEAIAKPIAQSPSAEPKKSSEEKSDKSESKVDESSESKESEESSESKEN
The following text describes a protein:
Function:
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTDDIPSPCDLLVIGTGLTESIVASAASRIGKQVVHVDHRDFYGSNWATFSFNNLHNVLGVNKGLTECIEETKKETYSIHIGLNSNTVLNVVEKWFISDEDVEATIDNQLRIEETNNGILKQTWTKSEVLKHSRKFNFDLSPKLLYSKGEMVEVLISSGICRYAEFKNVSSIYTYDNVESGLLPVPCSRADIFNSKDITMIEKRLLMKILSMCVEYETKPEKFQEDEMGNFGNFLDAHKIQGKVRKYLIDSVAMAKESTNFQDAVKNIQKFVRSIGRYGNTPFLWTLYGSGELPQCFCRCSAVFGGVYCLKRSTRSIIIGSDGQATGIMCDNQNLKAKFILIEDSLNPLATIKSGISRAILVTNKALTSNDQAVLINLPSLNGKEPVRILELSASTMACPQGLYVVHLITRQVTTAIEDLREVIDTFFSAVESNENEALHKPQIIWSLHFNINEYESYADMLPLNLYSSPGPNSSMDFDNHVIQARNIFKSMFPDEDFLPRVPDPEDVILEGSAEEVVLQESLENQEVHNVHE
The following text describes a protein:
Function:
Acts as a tumor suppressor in lung cancer. Inhibits tumor cell growth by inhibiting cell proliferation and migration and promoting cell apoptosis. Inhibits metastasis of lung cancer by suppressing beta-catenin expression in the Wnt/beta-catenin signaling pathway (By similarity).
Subcellular Localization:
Cytoplasm. Membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in lung cancer cells.
Sequence:
MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHKPQLGDSSPVWSGVCFLLCGICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKKTSSLYPLHLASMSLACIGIGGCTLSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEITDNMSNGGPQLIFNGRV
The following text describes a protein:
Function:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Subcellular Localization:
Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MAEDVSSAAPSPRGCADGRDADPTEKQMAETERNDEEQFECQELLECQVQVGAPDEEEEEEEDAGLVAEAEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRNSAEAIIHGLSSLTAYQLRTIYICQFLTRIAAGKTLDAQFENDERITPLESALMIWGSIEKEHDKLHEEIQNLIKIQAIAVCMENGNFKEAEEVFERIFGDPNSHMPFKSKLLMIISQKDTFHSFFQHFSYNHMMEKIKSYVNYVLSEKSSTFLMKAAAKVVESKRTRTITSQDKPSGNDVEMETEANLDTRKSVSDKQSAVTESSEGTVSLLRSHKNLFFSKLQHGTQQQDLTKKERRVGTLQSTKKKKESRRATESRIPVSKSQPVTPEKHRARKRQAWLWEEDKNLRSGVRKYGEGNWSKILLHYKFNNRTSVMLKDRWRTMKKLKLICSDSED
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIGWGDVYKVVAATVPLYFALFLGYGSVRWWRIFTREQCDAVNRLVAFFALPFFTFEFTLHTDPFQVNYRAVAADVISKAVIVAVIGAWARFMSKGGCAVSWSITSFSLSTLTNSLVVGVPMARAMYGEWAQQLVVQLSVFQAIVWLTLLLFVLEVRKAAIGMYVDGAEAAAAAGKDVEAAGAAAAAGTVVVAAAAGKPSLWALVKVVAHKLARNPNTYASFVGITWACLANRLHIALPSAFEGSVLIMSKSGTGMAMFSMGLFMAQQEKIIACGTSFAALGLVLKFALGPAAMAIGSIAVGLRGDVLRVAIIQAALPQSITSFIFAKEYGLHADVLSTAVIFGMLVSLPLLVGFYIVLELIR
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MPPKRSNGKGNGVSVRPRDQPSLIVAFAKQISRKRCTVCSAEIPAGIFAAHRRECKVKSDDEDCQVLFSQTAEEKWAAGLITLDEMEEGRENSMRVKKEGETPTTSRGRQSSLSTRGRRATKRKMEERDSAEDDSDFVMASQKSPEEEETERKRDEPVRTRRSARVNLSANKRRSLDDDEIAAMDDVGENLDMTMFDEEEVAPPPSRRHTRSTGGGESNMILTELDGPPTPDSQGSSMEVETGFVPDIKEGSEDREVEEEAVDLDATLAPEGIEERVTTRRRRGRKDTVENREEPVQEKRMTRRGAKEASQNSQSSQEQQVPKKGRKGREEERKKREGEAKKKEEEKEKERKKKEEEETKRKEEEKAKEQPIAGLTRIVLRALEDKCVRHERGLVPSQELVQAAVITLDEEDPEVVPHYVYLMCKIMRRVLSTRSSTGRVHDESFWGEDLRMVSRFLSLNDDAKLLFIRLFTRKRGWHLPEKLREKYPYLKRMDETLVELQKEGFLENGKTALTSTEETLRLCSTEKLKLIAKDFRVDANKPKSGLIEALLKSAISQRQLFMAGTPGNTGRLLMMSKKHLGPVYRTSSSVNSFFRALFSLYSPVLTDSHLITEDRTINIISNFMFRMKEIHYDQIMRKAPFPCGELIGVYEDKEDLYGFVAAKDSEERMIRALDRHDVNGALVEAERAREKLTEMNTPRMDYLRTVPVHHQQYTTEAILTRIVSRGVDCLERKKDHAAACNWIKFIIKSQVLSSLLPHSIGALYERLALNLHYHCGESDEAIDEIKRALDDPLVPEKNRLNLDDRAKRILKEAWESRFALTPPTEITIEGETIGRDLGNERKNQFVKKNENGDVVSVGVEQIALDYFLSKGMEEGLHSEGEIWHLAFKLLFWDVIWCHQVGGGVWLCELQIHPVDYDYSLYEARKEAFEARFEVLRKSSLSDRLALIDEHWACSDTMMNRISITEMKSFLTACALPTLLGVMQILVKEPRHRRSGFPDLVLWSAGKQVVMVAEVKGPGDTLSTKQRLWLDFFMKEDGERVKAYLCKVTASGRKRLQ
The following text describes a protein:
Function:
May play a role in a switch from carbohydrate utilizing metabolism to fatty acid utilizing metabolism.
Miscellaneous:
MISCELLANEOUS: Present with 4490 molecules/cell in log phase SD medium.
Sequence:
MSDAGRKGFGEKASEALKPDSQKSYAEQGKEYITDKADKVAGKVQPEDNKGVFQGVHDSAEKGKDNAEGQGESLADQARDYMGAAKSKLNDAVEYVSGRVHGEEDPTKK
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MKEPLKIGLMDSGMGGLSVLKELLKYDSELEIVYYGDLKNSPYGEKDASEVLELVRSVCNFLQKENVSAILLACNTATSAAAQTLRKEFSIPIFGMEPAIKPAILQNPGKKVALLATPVTQREEKLQRLKSELKAEELVLSISCPGLAGLVDQGDFDKAEKYLRPILANLQEQDVENLVLGCTHYVFLKQIILKNFPNVKIYDGNSGTIKHLLNSLQVPRVILNGSQNNRSIYKLILNSEKEFHFRLASELLSLKE
The following text describes a protein:
Function:
Catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine (gamma-GC), the first and rate-limiting step in the production of glutathione (GSH).
Miscellaneous:
MISCELLANEOUS: Present with 5130 molecules/cell in log phase SD medium.
Sequence:
MGLLALGTPLQWFESRTYNEHIRDEGIEQLLYIFQAAGKRDNDPLFWGDELEYMVVDFDDKERNSMLDVCHDKILTELNMEDSSLCEANDVSFHPEYGRYMLEATPASPYLNYVGSYVEVNMQKRRAIAEYKLSEYARQDSKNNLHVGSRSVPLTLTVFPRMGCPDFINIKDPWNHKNAASRSLFLPDEVINRHVRFPNLTASIRTRRGEKVCMNVPMYKDIATPETDDSIYDRDWFLPEDKEAKLASKPGFIYMDSMGFGMGCSCLQVTFQAPNINKARYLYDALVNFAPIMLAFSAAAPAFKGWLADQDVRWNVISGAVDDRTPKERGVAPLLPKYNKNGFGGIAKDVQDKVLEIPKSRYSSVDLFLGGSKFFNRTYNDTNVPINEKVLGRLLENDKAPLDYDLAKHFAHLYIRDPVSTFEELLNQDNKTSSNHFENIQSTNWQTLRFKPPTQQATPDKKDSPGWRVEFRPFEVQLLDFENAAYSVLIYLIVDSILTFSDNINAYIHMSKVWENMKIAHHRDAILFEKFHWKKSFRNDTDVETEDYSISEIFHNPENGIFPQFVTPILCQKGFVTKDWKELKHSSKHERLYYYLKLISDRASGELPTTAKFFRNFVLQHPDYKHDSKISKSINYDLLSTCDRLTHLDDSKGELTSFLGAEIAEYVKKNKPSIESKC
The following text describes a protein:
Function:
Exhibits phosphatidate phosphatase (PAP) activity in vitro. May play a primary role as PAP in plastids.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Sequence:
MDLIPQQLKAVTLTHVRYRPGDQLGHFLAWISLVPVFISLGGFVSHFLFRRELQGIFFGIGLVISQFINEFIKTSVEQARPETCTLLEACDSHGWPSSHSQFMFFFATYFSLMGCKGIGFWFGLRSRWIMNLLHWSLAVVTMYSRVYLGYHTVAQVFAGAALGGIVGASWFWVVNSVLYPFFPVIEESVLGRWLYVKDTSHIPDVLKFEYDNARAARKDMDSAKSD
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Subcellular Localization:
[Phosphatidylserine decarboxylase 1 alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain; [Phosphatidylserine decarboxylase 1 beta chain]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MSTLPLKAVSRLWGRFNEIDIPYYLRVPGFKLYSWIFGVNLSEVSEPDLHVYPNLAAFFYRTLKPGVRPLDPNPNAVLSPADGKVIQFGTIEHGEVEQVKGVTYSLDALLGSVRPTKPSTNIVDSQVKTSDTHEKNAEEDVVRADEEFARVNGISYTLPNLFSGPWPKEGKPTDMPTDQSTAPRASSEAEVRADLALSEAERPWWAPASNKTPTALYYCVIYLAPGDYHRFHSPVSWVVESRRHFAGELYSVSPFLQRRMPGLFTLNERVVLLGRWRWGFFSYTPVGATNVGSIKINFDRELRTNSLTTDTAADRAAEEAAARGEPYSGFAEASYTSASRVLGGYSLKRGEEMGGFQLGSTIVLVFEAPKGIRPSLDEGYAGHRKGGFKWNIEQGSTVKVGEALGAVEEPQ
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MSDTIADEILRNGYAKTFTRHSVFLTGSTGSLGGCLLYKLALQLPTQKIFVLIRGSAESAIEKWRRLMPKQTQAILNTGKVHFVVGDIKKTDFGIEEAELSRLREEVTLVIHTAATITLDAGIVESIENNCLPSLELAKIVSRFRRLKLFLQISTAYVSSFLPDGYVGERVYSISDADPEDELAAILSTGNSLDTARFSSSYTHAKYLMERLLLKRYPLLPLLLVRPTIFGAAMRDPYPLYGPINSTPMNKFASLFFADRGGTHIWHATEGYETGANIVDEIPVDFVANGCLLHAASRTQGIVHLGAQLYVPFTFDDFLRLAEASAPPSIQKELPSLIFTQDRNAPQSLLADLVKVSTRNWVFDCGRSYWLKQMAGPLSLAACKHDVDALNSARIKEIYENTVKKLAKL
The following text describes a protein:
Function:
Probable serine protease inhibitor.
Sequence:
MDTEASRPSKKARGAVDSAGGGVAALALRLSKQLAEHDGSKNVAFSPLSIYAALGLAAVGARGTTLDELLALLGAALRHEVAEHMRASGARSAAQAGLPPGRRQVLKVEARAVDFVEKAEDAREEINGWIAEATKNLITSVLPPGSVHGDTRLVLANAIYFNSKWNGAFSKSRTKDRKFHRLDGTVVQFWKAKMKAYIMAQSYAIWEKVAKPYELPADNAITPKNLVHVENNYKARNYIIQGVAGARGTWSMTGSRDEAWEKLRSRIKVMRNRYYSMCVFLPDERDGLRALVMASGGPGFLFGHLPSPLSDQKVRKLPLPKFKLSFLCSMKGALQSLGHREAFSERADFSDMVEEEEEDVDVPLCVEEVFHKAVVEVDEEGTMAAASTAARFVFSCFGYKTPTPVDFVADHPFLFFIVEEMSGAVVFAGHVLDPSETSE
The following text describes a protein:
Function:
May negatively affect PAX8-induced thyroglobulin/TG transcription.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly nuclear.
Sequence:
MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKARKQAAERTQRLDEKRKKVKLDLEARERQAQAQGTEEEEESRSTTTLEQEIARLREEGSRQLEEQQRLIQEQIRQDREQRLRGRTENTEGKGTPKLKLKWKCKKEDESQGGYSRDILLRLLQKYGEVLNLVLSKKKAGNAIVEFATVRAAELAVRNEVGLADNPLKVSWLEGQPQGTVDPSPPGLSKGSVLSERDYESLVMMRMRQAAERQQLIAQMQQEDEGRPT
The following text describes a protein:
Function:
Protein phosphatase that dephosphorylates specifically tyrosine-phosphorylated peptides; especially active on dual-phosphorylated substrates containing a phosphothreonine-X-phosphotyrosine motif.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAQKPRTVICVGDIHGYISKLNNLWLNLQSAIDPSDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLGLLPRPSDGSDLKDTWKEYSKSEETEGWYTGEGFEDMHLQGRRWAGKIKATFNSVKGMAYKGSIYDAGSTFESYGVPHGSSDLMKAVPESHKKFLTNMVWVHEEDDVCIETEEGLKHCKLIAVHAGLEKGNNVEEQLKLLRAKDTSISKIQHLSGRKNVWDIPQELDDKHTVVVSGHHGKLHIDGMRLIIDEGGGFPDKPVAAIVLPSKKIIRDTDNLSS