lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSAVRNRNNVEKQSNNGAQLTEVQKKELADLQKVHPANEFGGIIGTFLLTFILPVVVYWIWASIEFNNGYLLRPETLSVEGVKAFLAQLYHYVITYAYPTKEAAIIYFSWFGFQAFLQHVVPGRKVLGSPLPGGARLEYTLNGWASWWITLIVIPIAIYFGLFKATILIDNYAPMMTVVNIWSFVFTFLLKIHAKLKGEEERMSGHFFYDFWMGFARNPRIGSFDLKLFCEARPGLILWVLMNFSIAAKQLEVYGEISLSVILVCCFHFWYIADYYYHEEAILTTMDIITEKFGYMLVYGDLSWVPFTYCFQCYYLYKHLVNGAPLHISIGYAIFVVSLKCFGFYLFRWVNSQKHDFRRNPEAPVWGKPAEFILTKRGTKLLCSGFWGICRHLNYTGDIILSWAWCLPCQFDSLAPYFYGIYFTSLDLHRCWRDHNACLVKYGDDWRAYCKRVPYNFIPGLI
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MCSTLCECDGIPDAVPPVGILEDAKGNTCKTCDDTAHVVLRKKDAYCVSCFLAASTHKFRSTLGKSKLIKPKQKILVAFSGGPSSAAMLTLLLDGFAEDAHKRFLFEPHLAHIDDSVASGKSEADPSLREEAVSLMSSSNLPFYTVPLELVVCSDVVTLDPATHGSTVPIAEVDGCRRTLASSFSSFKSATDRESFHRITLRRLLLKLARDNGFDKVFTAETGTQLAATLLSTIALGRGSQLRDQVSFVDDRDGHIQLLRPMREFSAEEVDLFNQHRNVTFRQSPPKQAASIVRLTERFVNGLQRDFPATVSTIWRTGDKIAPPVRTAGSCSLCGSPLDTVDVPVASAVEALRLTRETSRQREGEGRTSLTTSEDEGCRELCYACQSMMAAGDRATMKPLLDSTNPVKPQLSEENGTATKGLPVL
The following text describes a protein:
Function:
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
Subcellular Localization:
Endosome.
Sequence:
MSNPSSSSSRWPRALDESPSEIDLYDSSKERVAYENLADLYTIITATEHVERLYGQDNITHTEYTTECNKLISQFKIAEKAALGKNNMTTETFMKKYQMDCPRAADRLLRMGVPEPLKTSDGSGHANVAITVAETVQHFITAMDAVKLEQRAVDELQPLLSDLMNALVQLPDTPNDFGPNYKVKKWLQKLNRMRAVDMIDDDDGRQLYHDLDSAYSEFSRYLRSK
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MQAIICLAIYKNRVKGIVRSCLVDLLLLLGPDRWREAYPFAGGSNQSPVAILTKHVHSDPILLPWFTGYDPGASKTIKNTGKGCRIAFDDTFDRSVLRGGPLPNIYRLRQLLIHWGSTDDKGSEHVVDLQRHAGEIQLVHWCSKYSNYLDACRKNDGAAILAMFLKVGKNPKPEMKRIIEELDAIKTKGKEVPFPNFDPSILFPQNRNYYTYQGSFTTPPCEECVTWLILKEPIIVSEEQMAKFRTLSCNAANEPFSPLEDNWRPLQPLNQRMIRTTCQ
The following text describes a protein:
Function:
Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MAVFASRYERKLPIDDTQALSCEITAVQEVAGHTEYLLRVWRGASNKNYWTVLRRYNDFDRLDKSLRVSGIELPLPRKRIFGNMRPEFIAERKQALQEYINAVLMNPILASSLPAKRFVDPESYSQSFHDHAVQNAMLCLRNDTTWSLGGSMGAIGWRLRKHYFKVTTKPPEKSSNKQLVKSGSQTHQSKHFAAGSSNGSGHSIDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMGLQHPHIEPVLLAAHTENGCLVIRKFHKHGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATYGKQILEALIFLHSKGYAYGHLHSGNIVIVDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQESVVRQITECPEALKCLLESILSKEACKAGLPTLEQLLGHRFFLQYASTESAGAAANAEKPYFKLSLNAKELLKQAAIKSENRLRDEQKSVKNQKRIVRVQELMSSEEEKRKSKQKAKLEHKQSKLKQQSSIQTNNGRLSLVAATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGIKSPPLTPGPHLGSIYQQELPSTTGAPVERQSSTPNMLSEDAEGGDGDEPTRSALLESICKFNRGSLRKVRSND
The following text describes a protein:
Function:
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
Sequence:
MNTQFKLIGFDLDGTLVNSLPDLALSVNSALAEFNLPQAPEELVLTWIGNGAPVLIARALDWAKKQTGKVLTETEVKQVTERFNFYYGENLCNVSRLYPNVKETLEILKEKGYVLAVVTNKPTRHVQPVLAAFGIDHLFSEMLGGQSLPAIKPHPAPLYYLCGKFGFEPRQVLFVGDSKNDIIAGHAAGCAVVGLTYGYNYNIPIRESNPDWVFDDFAQLLSIL
The following text describes a protein:
Function:
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.
Sequence:
MTVIDITSKDQFTQQTTVAAGSKLVALYFHTAWAEPCKAMSAVFSAVSEEPAHKDVLFLAIDADEHAEISELFEVAAVPYFVLIKEGAIVKEISGSDPKDFVSALNEYTAGSNSTGAAATASAPAEEYGEEETEEQLQERLKKLTSAAPVMLFMKGTPSEPKCGFSRQMVGILREHQVRFGFFDILKDESVRQGLKTFSDWPTFPQLYINGEFQGGLDIIKESLEEDPEFFQNTLSS
The following text describes a protein:
Function:
Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity).
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MSMAVETFGFFMATVGLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSLGVYNCWEFPSMLALSGYIQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGALHILAGICGMVAISWYAFNITRDFFDPLYPGTKYELGPALYLGWSASLISILGGLCLCSACCCGSDEDPAASARRPYQAPVSVMPVATSDQEGDSSFGKYGRNAYV
The following text describes a protein:
Function:
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Subcellular Localization:
Plastid.
Sequence:
MPIGVPKVPYRIPGDEEATWVDLYNVMYRERTLFLGQEIRCEITNHITGLMVYLSIEDGISDIFLFINSPGGWLISGMAIFDTMQTVTPDIYTICLGIAASMASFILLGGEPAKRIAFPHARIMLHQPASAYYRARTPEFLLEVEELHKVREMITRVYALRTGKPFWVVSEDMERDVFMSADEAKAYGLVDIVGDEMIDKHCDTDPVWFPEMFKDW
The following text describes a protein:
Function:
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Sequence:
MLEDDFGRDVSGVRVSLTDRCNFDCVYCHNEGLGDTRGPIDPRENELSTDRVVRFLSVAHEFGVDAVKLTGGEPMLRSDLEAIIRRTPDDMAVSMTTNGTFLPGRAADLVDAGLERVNISQDAMDNDAFAELTQSGAYDAVLEGVEAALDAGLAPVKLNMVVFEPTAGYVPEMVDHVAARDGLRLQLIEYMPELAGHPEWAIDIDRVHDWLADRADRIETREMHDRRRYWVSSRDAGSTADDAAQSVTPDGGAHPDQGMVEIVDPVGNPQFCANCHRVRLTHDGYLKGCLNRNDDLRGIGETTQSMRAAFRETVANRVPYYGEYMTRTDDGGWEINDDYLDVEGDRDPYEYAADDSA
The following text describes a protein:
Function:
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
Miscellaneous:
MISCELLANEOUS: The C-terminus of the heavy chain binds to ganglioside receptors.
Sequence:
MPITINNFRYSDPVNNDTIIMMEPPYCKGLDIYYKAFKITDRIWIVPERYEFGTKPEDFNPPSSLIEGASEYYDPNYLRTDSDKDRFLQTMVKLFNRIKNNVAGEALLDKIINAIPYLGNSYSLLDKFDTNSNSVSFNLLEQDPSGATTKSAMLTNLIIFGPGPVLNKNEVRGIVLRVDNKNYFPCRDGFGSIMQMAFCPEYVPTFDNVIENITSLTIGKSKYFQDPALLLMHELIHVLHGLYGMQVSSHEIIPSKQEIYMQHTYPISAEELFTFGGQDANLISIDIKNDLYEKTLNDYKAIANKLSQVTSCNDPNIDIDSYKQIYQQKYQFDKDSNGQYIVNEDKFQILYNSIMYGFTEIELGKKFNIKTRLSYFSMNHDPVKIPNLLDDTIYNDTEGFNIESKDLKSEYKGQNMRVNTNAFRNVDGSGLVSKLIGLCKKIIPPTNIRENLYNRTASLTDLGGELCIKIKNEDLTFIAEKNSFSEEPFQDEIVSYNTKNKPLNFNYSLDKIIVDYNLQSKITLPNDRTTPVTKGIPYAPEYKSNAASTIEIHNIDDNTIYQYLYAQKSPTTLQRITMTNSVDDALINSTKIYSYFPSVISKVNQGAQGILFLQWVRDIIDDFTNESSQKTTIDKISDVSTIVPYIGPALNIVKQGYEGNFIGALETTGVVLLLEYIPEITLPVIAALSIAESSTQKEKIIKTIDNFLEKRYEKWIEVYKLVKAKWLGTVNTQFQKRSYQMYRSLEYQVDAIKKIIDYEYKIYSGPDKEQIADEINNLKNKLEEKANKAMININIFMRESSRSFLVNQMINEAKKQLLEFDTQSKNILMQYIKANSKFIGITELKKLESKINKVFSTPIPFSYSKNLDCWVDNEEDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQLVPGINGKAIHLVNNESSEVIVHKAMDIEYNDMFNNFTVSFWLRVPKVSASHLEQYGTNEYSIISSMKKHSLSIGSGWSVSLKGNNLIWTLKDSAGEVRQITFRDLPDKFNAYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLKLDRCNNNNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLRYDTEYYLIPVASSSKDVQLKNITDYMYLTNAPSYTNGKLNIYYRRLYNGLKFIIKRYTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPKDGNAFNNLDRILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNASLGLVGTHNGQIGNDPNRDILIASNWYFNHLKDKILGCDWYFVPTDEGWTND
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MFEARRASMEQARWQTLEAANRGLMEIEHSMSGGEFFSSYLDSFKAGGQAQCTTVWTKTTIAYRCRTCQVNDSSAICVSCFQAGDHRHHDYVMYHSDSGGCCDCGDPAAWKEEGFCSVHRSSSLHKELTIPAHLNEVTSKAVELVLKELCIWVEIIMDAKISDRSYQSSPFKVTMAEVYVKWLQKICSVAALRNIVVVEITSVHSDVASMLRNDRTRNRSFLEILLSTYGRMPDSLMEAETTLFLQMLYDQQFKDTFSRALMRHYSGLIEPAAITPKLLGEYKALDQSLDRVMVQLFNVPEITLNLIQTDRLLESFTSVLGSVLSHCTSRRDGTIDVDHHAIKGKVYGRPQGDLKLIVAHESVAFHVLKERPDVFRNILSTLSLLQWMNPYSRSETVGLKGQEAWTAAITLEMNTMTIPFGLIGRCFSGFPGNEEAVKSALISAACVAMGSLREFLTKVETSQSSEEKLSLHIPLHRVLSAVISKLVMLPWRETGQGFLDNLQPALTEAEVLALMDHPLRVVVWMAEIRAHMWQRSSEDFSRLELIYRGSIWHDQSMDMDILMLQFCCVAVENMGQSVISMMAKKFGLLDMVTMPVLDSGGDSRESTLAKISMLQDFLRLLLLIIRERRNTGMFERESLRYDVIQWLCVRDQTYSQLAYTLGGNLIDQTRLSSVLQEVAIYNIPKVQERGFYQLKQECWKEFDPLFAHFYANDLEEAQERAISVGKLPHYWRLQPPREVKPPFNRLIKILHTQACHQLTWNVLHSVTNLIQDEATATSAEALGVMSLQILEMALADIRDGGLTPQNVPMTSQSWQVQSSSMVHCSDISDFIYAKPHISSVSGVVEWKRRDSTSSHPSIYEMLISLQRYKDSFRLVDSANHVIQLQCSYSITKSGSDSCRSQVFDVYIDDERRKLKKKRQEAILADFKARQKAFLDQVYHEEDSNEVKAKEDAGTPVFEDSKPQEFSTAGGGSSWAVPGDKTPSKDADQEKERHECAFCRSECDGDESPTGWIALVQRYNLPSLIHSRGEVVRSIKEVTSLLSGNHQSEGSDGNVPGLLTVVTESSPNDASVSGPLDLHPTEHVRCCGHQMHQMCFQRYADSLLKRHYAKSTYEGKGIIDLGKMDFLCPFCRRLANVLLPDVNKVVPWARLETKQELHKKEALQDKENQTDEELAYFSLEGLIPHGSSEHFEDMQYWKHYWSTHQDLAESIRIFAAQSLRVRKKFLREPPDLDGLPLCQILWETLAENIIHCEVETREVVTVKDIAASSSSSASASPAENLSWRGDAAHWLGLTELGKLAMLTNTMPCEGKQKKMHLLLQWLGFDENVIKQRFEDDIETPANTTQVDSLSGSAVGDISQHNQSGEEVIEKAESMVMETANEKSTDESRSPRGHKNYWESGSDDYRSKRNRARFKFAGADDNEVGWRLQKKHNLGKVLESSEPMDIGWLWSNSKASKSGSLASGDPFELLIMLLVTFEGWPTFQDLMAMVRVAYVLAATKASVAFNKLSGEDENKLVAMDKAKIEVLQAACLPFLRRVALMVQIIARKETRELANGQAIEWMESECLQQWLDLPKIQEAVELGMQGIHGVKMQQLFQNNQPAPLLYKVPRQALLTKLPEVFQELVLQNLKVACLNCHKTPHEPAICLVCGNLFCCGTDCCNIDGMGECYRHADKESAGVGIYLLIRSTQLVLLRSNRVCMAPSLYLDLHGEEDAYLKRGHPLHLCHLRLNEVRRLWLTASFDHETHILHSSQIGGRVL
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLSLSHLSLVLGQWLQPIVEQLPPSVQDVVLHPLAPKALLVLLALAFLRQTNRILTNWSMNNGERDRFDHERELVLLTGGCSGIGKQMVLDLAKANVRVVILDIQEPSFTLPSGTAFFKADITSSASIAEVAEKIRAEHGDPTVLINNAGVGHDGTILQKPEAKIRQTFEVNTVSHFLMVREFLPSMIEKNHGHVVTIASMASFIGLGDMVEYSCTKASALAFHEGLRQELRLWYKAPKVRTTVVHPLWVRTPMIKVLTDAGSEFKQPILTPEMVSEAVVKQVLAQSSGQIILPGYYTPLSMLRALPNWFQEFARGVGSRDFIKLREWQQKQLKTQ
The following text describes a protein:
Function:
Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDFNNCGFIDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTPGCRDFIEACIDHGSQVNYINKKLDKAAISYAADSRDPGNLAALLKYRPGNKVQVDRKYGQLTPLNSLAKNLTDENAPDVYSCMQLLLDYGASPNIVDQGEFTPLHHVLRKSKVKAGKKELIQLFLDHPELDIDSYRNGEVRRLLQAQFPELKLPEERHTGPEIDIQTLQRTLRDGDETLFEQQFAEYLQNLKGGADNQLNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDINSRPGRANEANLVETAVIYGNWQALERLLKEPNLRLTPDSKLLNAVIGRLDEPPYDGSSHQRCFELLINSDRVDINEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYIGSKSAFGTLPIKDMPPEVLEEHFDSCITTNGERPGDQNFEIIIDYKNLMRQERDSGLNQLQDEMAPIAFIAESKEMRHLLQHPLISSFLFLKWHRLSVIFYLNFLIYSLFTASIITYTLLKFHESDQRALTAFFGLLSWLGISYLILRECIQWIMSPVRYFWSITNIMEVALITLSIFTCMESSFDKETQRVLAVFTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLTGEFDAGSIQFTSIYTYLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGRAGFLLGNHLFRSICQRLMNIYPNYLSLRQISVLPNDGNKVLIPMSDPFEMRTLKKASFQQLPLSAAVPQKKLLDPPLRLLPCCCSLLTGKCSQMSGRVVKRALEVIDQKNAAEQRRKQEQINDSRLKLIEYKLEQLIQLVQDRK
The following text describes a protein:
Function:
SOSEKI proteins (SOK1-5) locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes.
Miscellaneous:
MISCELLANEOUS: 'Soseki' means cornerstone in Japanese.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=SOSEKI proteins integrate apical-basal and radial organismal axes to localize to polar cell edges.
Domain:
The DIX-like oligomerization domain is required for polymerization, edge localization and biological activity.
Sequence:
MSSRVFRATPDNNYLVPRRSKDQQDTSPDRNRIWSEPRLKPVVNRKVPVVYYLCRNGQLDHPHFIEVTLSSHDGLYLKDVINRLNDLRGKGMASLYSWSSKRSYKNGFVWHDLSEDDFIFPVQGQEYVLKGSEVLDSCLISNPRSLLETSSFRDPRSLNPDKNSGDDIPAVINRRRNQSWSSIDLSEYKVYKATESSAESTQRLAADASTQTDDRRRRRRPAKEEIEEVKSPASYENQSTELSRDEISPPPSDSSPETLENLIKADGRLILRPSESSTDHRTVESLSSGRMRASAVLMQLISCGTMSFKECGPVLLKDQGLALNGRSGCTITRGAEDNGEERVDKELKSFGRVQLEDKEYFSGSLIETKKELVPALKRSSSYNADRCSRMGPTTEKDEEEAVRAKCIPRKPKPVAKRNNGGQQ
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MSSEGSWQEKGKGTKITDESCKLGFRKELNSRFQAYTEEINLGNVEESIFGKKRTSVVLYVARMRAILDHVMNRLPSSRFINHDGYRRENERGIRIGNYTYYAGGHWVPLDCEPKWKVAIVIPFRNRHNHLSILIRNLVPLLKLQMLEFRIFVSEQDNTLIFNRGMMKNIGYLEALRFGRWDCVVFHDIDQIPMRGANYYGCDGMPRHFCARPEEMEFKPAYALLFGGVVGVTEEQMTKSNGYSNFYWGWGGEDDDLLKRLYSSGYKPTRDLREGFYRTLNHTKKTQNEMCDEAFCLLDSCTKRMSWDGINNAAYTASRLKLSLLFTQISVDIRREKWNSWFGPCTNTEKLVDTDESVT
The following text describes a protein:
Function:
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Sequence:
MKLTIAGDSHGKYMVAILEGLPSGIRVDEELIRRDLFRRRNCYGRGKRMKMEEDAFEIVSGLWKGITTGAPVTILIPNRAGNPVKDVRSVPRPGHIDYAAWVKYKLPDLNIYVERSSARWTVALTAAGSLLKSLLKEFGIEVLGFVTRLGNVEARDIPGDFEELKRRRDESVVFCPDPEATKEMVAEIDRAKEEGNTLGGKVKVIARGVPAGIGSYSDLFKKLDSKIGSLFFAIPAVKGVVIGSEEMWYGFDYLDEFELEDGKIKRKTNNLGGIEGGITNGEDVWVNVSVKPIPTTGKPLKSVDLRTMEPAKTPYVRSDVTAVPPASVVCEAALAVVISDALLEHLGDGNIDDLKRRFENENLPRWNDGFWKEHYR
The following text describes a protein:
Function:
Catalyzes phosphoribosylation of neamine using 5-phosphoribosyl-1-diphosphate (PRPP) as a phosphoribosyl donor to generate 5''-phosphoribostamycin in the biosynthetic pathway of butirosin.
Sequence:
MKDNPISLFHELESYVRGSKDTLHRYMYACILEQRLADLLLLSRCGVHPDDEDRLAVRLASQRSLCVQAASDLAEGTEEARGSTPAWPDCKVTKSSAAQKRPELLSLVKVMQELRTPECSGYDLCDLEVCREDALHWLRDHADPSSPPVLIGVRTGGAFYAPLWSSALQQRWGNKALYHTVRALRMPSDPGASLYLPEELSILPAAIEPDTDIVILEDQPHTGGTVLELAGRLSAKYRLNKPVWVSSPGRLFQIENGRLAKCSDRIPLNTGTRKRIWQMLGNSEEVAEFLLPKLGLTDAHPADLEAVPYKSVPQWNDPMYRREVPFRINPKKTPFYIRRKSTNEPVVFAKFIGKDLFGDFQFHQLKKFEKYFPDILAYQDGYVMTKYEPGLKEMREMFVNMPSAVTREICQSVSGYWKTLLDSCQISGGHPVHPLADHWQARLGEMEDFIGRKLPYDLDWFERSLHTEWTSSAHVYTSLPYANQYGHWKARLSAGQRLKTYRFHIDSTWGGTSSIEVELASFLLENRVRPDDFRLLVNQVKKEAGSLTIEAVTDALPIACVLQAANLLKQAKDESRLSKELILSEAMQSFEYLQAMKPKLSDVR
The following text describes a protein:
Function:
Retroviral restriction factor that prevents infection by gammaretroviruses. Acts by interacting with the capsid protein ca after entry of the virus into the cell. This interaction presumably disrupt the capsid thereby inactivating the viral genome, making it unable to enter host nucleus and integrate into host genome.
Sequence:
MNFPRALAGFSSWLFKPELAEDSPDNDSPDNDTVNPWRELLQKINVADLPDSSFSSGKELNDSVYHTFEHFCKIRDYDAVGELLLAFLDKVTKERDQFRDEISQLRMHINDLKASKCVLGETLLSYRHRIEVGEKQTEALIVRLADVQSQVMCQPARKVSADKVRALIGKEWDPVTWDGDVWEDIDSEGSEEAELPTVLASPSLSEESGYALSKERTQQDKADAPQIQSSTSLVTSEPVTRPKSLSDLTSQKHRHTNHELNSLAHSNRQKAKEHARKWILRVWDNGGRLTILDQIEFLSLGPLSLDSEFNVIARTVEDNGVKSLFDWLAEAWVQRWPTTRELQSPDTLEWYSIEDGIERLRELGMIEWLCVKATCPQWRGPEDVPITRAMRITFVRETRETWKSFVFSLLCIKDITVGSVAAQLHDLIELSLKPTAAGLTSVGSVGVLSLSPWKHQSNS
The following text describes a protein:
Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Sequence:
MNSKLQTISRYMLRQKCAFNSMRSISTSMPSLISHKHHIGKDPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHWYLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYEILRDICPEISDADTGKIRSEKFPHLRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELEGERICVQVPMFHAFGVIISIMAALTKGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIKKAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKAYAKGKLAHFKVPRYVIPIDAFPKTTSGKIQKFKLVEAFKAKETELKAARL
The following text describes a protein:
Function:
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
Miscellaneous:
MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Subcellular Localization:
Nucleus, PML body. Nucleus. Note=In granular structures; Nucleus, PML body. Note=(Microbial infection) Upon interaction with human adenovirus early E1A protein, the protein is redistributed to the peripheral areas of PML bodies.
Sequence:
MENKSLESSQTDLKLVAHPRAKSKVWKYFGFDTNAEGCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHPEEFCEFVKSNTEQMREAFATAFSKLKPESSQQPGQDALAVKAGHGYDSKKQQELTAAVLGLICEGLYPASIVDEPTFKVLLKTADPRYELPSRKYISTKAIPEKYGAVREVILKELAEATWCGISTDMWRSENQNRAYVTLAAHFLGLGAPNCLSMGSRCLKTFEVPEENTAETITRVLYEVFIEWGISAKVFGATTNYGKDIVKACSLLDVAVHMPCLGHTFNAGIQQAFQLPKLGALLSRCRKLVEYFQQSAVAMYMLYEKQKQQNVAHCMLVSNRVSWWGSTLAMLQRLKEQQFVIAGVLVEDSNNHHLMLEASEWATIEGLVELLQPFKQVAEMLSASRYPTISMVKPLLHMLLNTTLNIKETDSKELSMAKEVIAKELSKTYQETPEIDMFLNVATFLDPRYKRLPFLSAFERQQVENRVVEEAKGLLDKVKDGGYRPAEDKIFPVPEEPPVKKLMRTSTPPPASVINNMLAEIFCQTGGVEDQEEWHAQVVEELSNFKSQKVLGLNEDPLKWWSDRLALFPLLPKVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLYENARSGAEAEPEDQDEGEWGLDQEQVFSLGDGVSGGFFGIRDSSFL
The following text describes a protein:
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLRQPVPELRSFQSLSKYAGGPRSVLGRRTSAITVNRRQSQSTRRHEDVEALGSIEGSKETLQLSEHGRLASSSEASPSRWEGRQIEWGNEEQIEEESELPYPGFAEPALRCFYQARPPRKWALQMVMSPWFDRITMAVIMINCVTLGMYRPCEDGPDCDTYRCQILDIIDNCIFVYFAFEMVIKIMALGFYGPAAYMSDTWNRLDFFIVMAGIAEFVLHEYLGGNINLTAIRTVRVLRPLRAVNRIPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVINLPKTISENQSALFNNVKLTRFYIPEDTSLEYICSQPDANGLHTCSNLPPYTVDGVKCNLTLDEYDKVTNDSCINWNIYYNECQVMQRNPFQGSVSFDNIGFAWVAIFLVISLEGWTDIMYYVQDAHSFWNWIYFVLLIVIGAFFMINLCLVVIATQFAETKRRETERMLQERKMLLNRDSISCTGSEIGGASSKEEGDTVYAAFVRFIGHTFRRTKRAAKKKYTAYMEERAERKSSERQQRRKSKLDDMATLSRIEEKAEDEEDETTITRENGDDQIEQNGDGVRIKRVKIEEEPKIKIGNGNSNGPHYKHSSSDEESDEDGEEDQVYDGEEAKKKSTPSKLWWFREKIQKFVICDHFTRGILVAILVNTLSMGVEYHQQPEILTVILEYSNLFFTALFALEMLLKIIASGLFGYLADGFNLFDGGIVALSVLELFQEGKGGLSVLRTFRLLRILKLVRFMPALRYQLVVMLRTMDNVTVFFGLLVLFIFIFSTLGMVLFGCKFCNHPDTGLQCTSAQVISSICECDRMNFDNFLFATVTVFQILTQEDWNMVLFNGMAQTNPWAALYFVALMTFGNYVLFNLLVAILVEGFQESKEEEKRQLEEDARKQAVEEEDERKRELELIIAKTTSPAFNNGVAPAECTCQRPSSPEESPSPRLLSANYHPSPERKHSANLDAIIDKRLVLRNSAPFDRSPVSEGRDDSRLNRHASLVLPVANGVPYRRQRVHSWSGLCHHFNPNCPVHGRRALIETYAREKFLEASQELKQALAEEEKRNEAKQNTFVRKLLKKTCLHNRTEFSLFLMGPKNPLRIKCLQTTQKKWFDYTVLFFIGINCITLAMERPSIPPDSFERQFLHISGYIFTVIFTGEMMMKVIANGCFIGQAAYFKDGWNILDGILVVISLINIAFELLATGDSPKIFGVIRVLRLLRALRPLRVINRAPGVKLVVMTLISSLKPIGNIVLICCTFFIIFGILGVQLFKGMMYHCIGPEVGNVTTKADCIEDYRNKWVNHRYNFDNLGQALMSLFVLSSKDGWVSIMYQGIDAVGVDVQPIENYNEWRMIYFISFLLLVGFFVLNMFVGVVVENFHKCKEALEKEMREKEKEKRLKRKLKRQKFEESMAGKRKKMERNYPYYHDYGHTRLFLHGIVTSKYFDLAIAAVIGINVISMAMEFYMMPMGLKYVLKALNYFFTAVFTLEAAMKLIALGFKRFFIEKWNRLDMFIVILSIAGIIFEEFEALELPINPTIIRVMRVLRIARVLKLLKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFGKLECSEDHPCDGLGEHAHFKNFGMAFLTLFRIATGDNWNGIMKDALRDDCDSSDHCETNCCVDPILAPCFFVIFVLISQFVLVNVVVAVLMKHLEESNKRDAEGPAEPTGENIENEITKSDDDEIVEEHEPLAIEHVKEGELDEEEETEEGPTTQIPDGHGGIKRLSMQVLEQELIEVERHLEERYRRASECLGGELQPLNPGEIEDLDDPEFRPRSRSHRPRARTNSALSNKSRGSHKSAL
The following text describes a protein:
Function:
Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Subcellular Localization:
Nucleus.
Sequence:
MSRGCCPHLLWDVRQRSLGLEEPGLLRRRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTNLAITNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGLVARFVPPHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKVPSSDERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRSRGGTSRSDVAAASGTVLESAEAVAQMEVDGPEQLQSSSSTVSAQAPSTSSSTESPPSTSLLSSPDNEQRPSLETPAPPTLSQSELMAPELAILRRGLQRLRLKKAEQQRQRELAEGSAQQSCSSDQPSPKGSSQDPQPTDDEKASPRAGTGEPVLSLHYSTEGTTTSTIKLDFTDEWSSTASSSRGSGNYSKTEGPEESLRTQSSEAPTPESEESKIPEESQEENYEELASAHENVTPQSVVDTSDQPESNIEEGNYPHLDLTCQVPGEGLSNKDMEEQETLSQQSAESTANPNNTNNELQSQPDSSGLASHEESSTRSSAFQETDDSDDDPVLIPGARFRGGVGHRKEGANLISLGREFHSQGATTEKALSLVPTSRACEGGRTESRAPPDNLNLRDGSQGEICSDRRSAVARIQELFRRRKERKEMEELETLNIRRPLIKMVYKGHRNSRTMIKEANFWGSNFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESKIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENEDEE
The following text describes a protein:
Function:
Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.
Sequence:
MSLHFHTSVPASCFNRTRSKDISNRSNANKFIVLQARKHVATAKVFDENIARRTANYHPPIWTHDYIQSLQSDFVGESCDERAMKLVAEVRTMLDRVLDPLEKLELVDTLQRLGLSYHYENDTKRILESVNAEESNVVWKKGNLYATALEFRLLRQHGYKVTPEVFSSFMDEMGNFKAGLCEDCKGLLNLYEASYHLVEGESILENARDFAAKHLKQCLKQNKDEYQFMLVEHALELPLHWRIERLEARWFIDVYERREDKIPILLELAKLDFNIVQAVHQDDLRYASNYAQQHDKMNYHLARGHQNNFLLSTANFAKKIANLKKSGWWTDLGLGEKLTFARDRLMGNFLWTVGVASDPQFGHARRTLTKINALITIIDDVYDVYGTLDELELFTEAVERWDVNAMELLPEYMKICFLALYNSINEMAFDTIKEQGFDSIPFLKEMWADLCKAYLVEAKWYYGGYTPTLKEYIDNAWISISAPVILSHAYFLTNSIRKECLECLKEHSQVVYCTSMILRLVNDLETSSDELERGDVPKSIQCYMHETGFSKEEARHYIRNLIDATWKMMNENRIAQSPFSQTFIQIALNLARMAQCMYQYGDGHGIEVNETNNRVLSLLVLPIPLQLGLNTYN
The following text describes a protein:
Function:
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
Sequence:
MSLHLVIIDALNLIRRVHSAQPDPNDITRTAETTTRTLQRIINEAQPSHMIAVFDHHLSDRGWRAELLPTYKANRKPMPDVLQQGIDAIQDAWWQLGIDSLLSEGDEADDLVATLACKVAAHQEKVTIISTDKGYCQLLSPTLQIRDYFQQRWLDEPFIAQEFGVTPAQLTDYWGLTGVSSSQIPGVAGIGPKAAKEILNQFSSIEEAYASPELPAKYRKKLDPHIEMARICKQVSALKTDIELGFNLQDIRFNSSSAD