lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB.
Subcellular Localization:
Cytoplasm, cell cortex. Cell projection, filopodium. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Expressed at the tips of filopodial structures located at the trailing ends of cells. Found in the focal adhesions at the cell-substrate interface.
Sequence:
MATKGLNMDDLDLLLADLGRPKSSIKVTATVQTTATPSSGKNFDNSDIQNEIQSIIEELDQQPQTVQTISTPAPKNHNTTTTTASFSVSSQPAPQPPQQSQQIDGLDDLDELMESLNTSISTALKAVPTTPEEHITHANSNSPPPSLHKNTSSTNSASSLSRPNNNPSVVSTPQPGKVTSTATITTKKQPALSKATLETTSGNNVYSSQPSQSQPQPYKVTATNSQPSSDDLDELLKGLSPSTTTTTTVPPPVQRDQHQHHHQHQHHHHHNPNHNQTQTVTTQINIGRTNTPNNNNNNNTNSPKVVHGDDLDNLLNNLTSQVKDIDSTGPTSRGTCGGCRKPIFGETIQAMGKFYHPEHFCCHNCQNPLGTKNYYEQESLPHCEKCYQELFCARCAHCDEPISDRCITALGKKWHVHHFVCTQCLKPFEGGNFFERDGRPYCEADFYSTFAVRCGGCNSPIRGECINALGTQWHPEHFVCQYCQKSFTNGQFFEFGGKPYCDVHYHQQAGSVCSGCGKAVSGRCVDALDKKWHPEHFVCAFCMNPLAGGSYTANNGKPYCKGCHNKLFA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the thioester bond of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) in peroxisomes, a necessary step to form the naphthoquinone ring of phylloquinone (vitamin K(1)). Displayed also slight thioesterase activity towards benzoyl-CoA. Is not active on phenylacetyl-CoA, succinyl-CoA and palmitoyl-CoA thioesters.
Miscellaneous:
MISCELLANEOUS: May originate from a horizontal gene transfer with a bacterial species of the Lactobacillales order.
Subcellular Localization:
Peroxisome.
Sequence:
MDPKSPEFIIDQPLKILGFVFDELSATRVSGHLTLTEKCCQPFKVLHGGVSALIAEALASLGAGIASGFKRVAGIHLSIHHLRPAALGEIVFAESFPVSVGKNIQVWEVRLWKAKKTETPDNKIMVSTSRVTLFCGLPIPDHVKDAPDELKKVISKL
The following text describes a protein:
Function:
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
Subcellular Localization:
Lysosome.
Sequence:
MNEWNVVARTTSPEISRGLGKRFRRALFQPPGPGGTCPPRPLPGPARMGDNSSPISVILVSSGSRGNKLLFRYPFQRPQEHPAAQPSQPRSRYAVNSSGDVSEDQDGDSSEQCPVTDEQLVSGFSDVILATILATKADVCGQKFELKIDNVRFVGHPTLLQHGLGQVSKTDPSPKREIPTMILFNVVFALRANADPSVISCLHNLSRRIAIVLQHEERRCQYLSREAKLILAIQDEVSAMAETGEGPQSPFRHILPKCKLARDLKEAYDSLCSTGVVRLHINSWLEVSFCLPHKIHYVAANSIPPEAIEKSLKAIRPYHALLLLSDEASLLGELPVDCSPALVRVVKTASAVKNLQQLAQDADLALLQVFQLAAHLVYWGKAIIIYPLCENNVYRLSPHASVCLYSPLARQFSSRFPGHDLPSVLAKFSLPVSLSEFKNPLAPPVQETQLIQMVVWMLQRRLLVQLHTYVCLMVPPAEEPPPPPRARDDDVPFSARGGGGGRSLSTPNALSFGSPTSSDDMTLTSPSVENSSAELIPSGDSPLNRRMTESLLASLAEHEREAILSVPAAQNPEDLRMFARLLHYFRGRHHLEEIMYNENARRSQLLTLFDKFRSVLVVTTHEDPVIAVFQALPNCPPGPARGTLPCRPPTRLPAGPAARLPSTCLPAHRSAHRLTLAGDVEAEMHAVDEVDVQGSRAHEHALVAWRLLAPSGVGGLVLGTQVGLCLNHPPTQLLPVGEPPDQHLKDISRPPPVPAFLLDLHLIHLAPGDCGV
The following text describes a protein:
Function:
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
Sequence:
MSKRKEDREEVERSLDAEMEELLPADELEIFGRVLEPLGKGHFRVECIDNLIRICRVRGKLRGRRAWIKRGDIVLISLWPFQRTKGDIVVRYDRQQVEWLIEKGYIPRDWATLEEG
The following text describes a protein:
Function:
A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.
Subcellular Localization:
Secreted.
Sequence:
MWKSRRAQLCLFSVLLAFLHSASLLNGDSKYMVLVPSQLYTETPEKICLHLYQLNETVTVTASLVSQSGRKNLFDELVLDKDLFQCVSFIIPRLSSSDEEDFLYVDIKGPTHEFSKRKAVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKMLRPLNELLPLAYIEDPKKNRIMQWRDIKTENGLKQMSFSLAAEPIQGPYKIVVHKESGEKEEHSFTVMEFVLPRFNVDLKVPNAMSVNDEVLSVTACGKYTYGKPVPGHVKINVCRETETGCREVNSQLDNNGCSTQEVNITELQSKKRNYEVQLFHVNATVTEEGTGLEFSRSGTTKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEKVFIKAQELSYTSATTTDQHGLAEFSIDTTCISGSSLHIKVNHKEEDSCSYFYCMEERHASAKHVAYAVYSLSKSYIYLDTETSSILPCNQIHTVQAHFILKGDLGVLKELIFYYLVMAQGSIIQTGNHTHQVEPGEAPVKGKFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLRFSTSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLLKPESELSPSWIYNLPGMQQNKFVPSSRLSEDQEDCILYSSWLAEKHTNLVPHGTEKDVYRYVEDMGLTAFTNLMIKLPIICFDYGMVPISAPRVEFDLAFTPEISWSLRTTLSKRPEEPPRKDPSSNDPLTETIRKYFPETWVWDIVTVNSTGLAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMQMSVQLEASPDFTAVPVGDDQDSYCLSANGRHTSSWLVTPKSLGNVNFSVSAEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPEGIKQEHTFSSLFCASDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIRNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNGEREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSAYITMALLESSLPATHPVVSKALSCLESSWKTIEQERNASFVYTKALMAYAFALAGNQNKRDEILKSLDEEAIKENNSIHWKRPQKSRKSEHHLYKPQASSAEVEMNAYVVLARLTAQPAPSPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVALDALSKYGAVTFSRSQKTTLVTIQSTGSFSQKFQVENSNRLLLQQVALPDIPGDYTISVSGEGCVYAQTMLRYNMHLEKQLSAFAIWVQTVPLTCNNPKGHNSFQISLEISYTGSRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVSNNNVLIYLDQVTNQTLAFSFIIQQDIPVRNLQPAIVKVYDYYETDEMAFAEYSSPCSTDKQNV
The following text describes a protein:
Function:
Fatty acid desaturase that introduces a cis double bond at the 8-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Delta(8) double bond to yield (20:4(8,11,14,17)).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The cytochrome b5 heme-binding domain acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
Sequence:
MGRGGDSSGQAHPAAELAVPSDRAEVSNADSKALHIVLYGKRVDVTKFQRTHPGGSKVFRIFQDRDATEQFESYHSKRAIKMMEGMLKKSEDAPADTPLPSQSPMGKDFKAMIERHVAAGYYDPCPLDELFKLSLVLLPTFAGMYMLKAGVGSPLCGALMVSFGWYLDGWLAHDYLHHSVFKGSVARTVGWNNAAGYFLGFVQGYAVEWWRARHNTHHVCTNEDGSDPDIKTAPLLIYVRNKPSIAKRLNAFQRYQQYYYVPVMAILDLYWRLESIAYVAMRLPKMLPQALALVAHYAIVAWVFAGNYHLLPLVTVLRGFGTGITVFATHYGEDILDADQVRHMTLVEQTALTSRNISGGWLVNVLTGFISLQTEHHLFPMMPTGNLMTIQPEVRAFFKKHGLEYREGNLIECVRQNIRALAFEHLL
The following text describes a protein:
Function:
Translocates aromatic and neutral amino acids such as tyrosine, tryptophan, phenylalanine, histidine, proline, leucine, valine, glutamine, as well as arginine. Transports the auxins indole-3-acetic acid (IAA) and 2,4-dichlorophenoxyacetic acid (2,4-D).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAIKDLTATTGDSSLPLIKSPPSETTGGDRTSALQTLGNIIVSIVGTGVLGLPYAFRIAGWLAGSLGVIIVGFATYYCMLLLIQCRDKLESEEGEEESKTYGDLGFKCMGTKGRYLTEFLIFTAQCGGSVAYLVFIGRNLSSIFSSYGLSMVSFILILVPIEVGLSWITSLSALSPFSIFADICNIIAMCFVVKENVEMVIEGDFSFSDRTAISSTIGGLPFAGGVAVFCFEGFAMTLALESSMREREAFPKLLAKVLAGITFVYVLFGFCGYMAYGDQTKDIITLNLPNNWSAIAVQIGLCVGLTFTFPIMVHPLNEIIEQKLKRIDWLQKHHNGYSNETGSVSKFAIFTTRTLLVVGLAAIASLVPGFGTFASLVGSTLCALISFVLPASYHLTLLGPSLNVWNKSIDVFIVICGLIFAVYGTYNTIVGV
The following text describes a protein:
Function:
Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. In ciliated sensory neurons, required for the sensation of nitric oxide and avoidance of NO-producing organisms like P.aeruginosa.
Sequence:
MSLFRLVEWVSQTIPNTSTILNASFFQDREQLVIGGENGQITISDPGFRDTNAHVLCTTETKYAILQMASDNFLPSMNNILAVLSPTKLTYYKVHFASPDETLASLDEIFSHSFSTSAWNMCVIPIEESTPQILVQSIDCKLSLFQGDQCVFSMVPLRALQPGPIGYCQTTQTLFVANNGFLAAIKFSLMSSGSQKKINYDWSFNLGDTAIQMKVTEGSKPTTIVLCRRHVSAFNATGSVVWQIRLEAVGMAMCLYRSLLINNTQFNRLIVSTSDDTLLIFQDNKLVWNCNAQMSPVALLVCSYNKSYENTITMMAPDGKVVVGYLGTEPNLYRLPEDKVIVNYAERMEEYKRMEQKIKESDAAGGAIKRKEGIQMKLSIGEIGKRTIEPNAASNAPYCNLIVEFSEVQNVSKLHINILSECASPSKQVILNVGTSKSTASIEIPFYVGSKKSPTSNKVTIAAHCAFTQLTVTKSIDLPFKVLFEESQIDRNAKYKVTIDTAGSVMPLNKLFSEFESENPQAIGFSLHGSDKTVSVFAANKSNRYRIQSEHISLLQITSRELVKRIAESAPGIEIGGVIPFEYMRETLDEIQELQTKKKEDSKKIDCRTKEVRAIEALSLNSCKTGNMGNLPSLDALFDKSYRELLDAMDSYNSLTAKIENQKASLNSLFQLAADLSKLSKVDTILNGSFWANTQQSLRDRLRWAVKTDRGNEMTMIEKLCEHSPKELPKIREEEEEEEQQVTA
The following text describes a protein:
Function:
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Subcellular Localization:
Cytoplasm.
Sequence:
MEIYLVTGNMNKKEEFLKMMDEELNVEFVNINLEEIQAQDIVEINEHKVKTAYNILKKQDNNKNKKRYVITDDTGLFISKLNNFPGPYIKWMQKALGSKGIADVVSRLDDNTCHAICTYSVYDGKDVHSFKGITNGKIVEPRGNNKFGWDNIFQPESLSKTFGEMTFDEKQNLSPRFKAFVQLKEFLMNEHKKYNNEF
The following text describes a protein:
Function:
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes (Probable). tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
Subcellular Localization:
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Sequence:
MKLIASNKKAYFDYEILETLEAGLALLGSEVKALRQTRVNLKDNFVKIIKGEAFLFGVHISYLDTIHAYYKPNERRERKLLLHKKQLLKWQIEASKERLSIVGLKLYFNQRNRAKIQIALVKGKRLHDKRQSLKEKALNKEILADLKHHFKG
The following text describes a protein:
Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAAHRSWLLVSFFLLEVLLLEAAKILTISTLSASHYILMNRVSQILQGGGHDVIKLLYEGGDIPDFRKENSSYQVINWRLPEDQQKTFENRWHRLIDEYAYGRSKYHTLLKIHQYFADLCSHLLSRKDIMELLQKENFDLVLLDSMDLCSFLIVEKLGKRFVSFLPFQFSYMDFGLPNAPLSYAPVYGSGLTDQMDFWGRVKNILMFFHFTKKRRDIFSQYGNTVQEHFAEGSQPVLSDLLLKAELWFVNSDFALDFARPLFPNTVYVGGLLDKPVQPIPQDLEDFISQFGDSGFVLVALGSVVSMIQSKEIIKEMNSAFAHLPQGVLWTCKSSHWPKDVSLAPNVKIMDWLPQIDLLAHPSIRLFVTHGGMNSVMEAVHHGVPMVGIPFFGDQPENMVRVEAKNLGVSIQLQTLKAESFLLTMKEVIEDQRYKTAAMASKVIRQSHPLTPAQRLVGWIDHILQTGGAAHLKPYAFQQPWHEQYMLDVFLFLLGLTLGTLWLSVKVLVAVTRYLSISRKVKQA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.
Miscellaneous:
MISCELLANEOUS: Present with 1590 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSIDNKLFVTEEDEEDRTQDRADVEDESNDIDMIADENGTNSAIANEQEEKSEEVKAEDDTGEEEEDDPVIEEFPLKISGEEESLHVFQYANRPRLVGRKPAEHPFISAARYKPKSHLWEIDIPLDEQAFYNKDKAESEWNGVNVQTLKGVGVENNGQYAAFVKDMQVYLVPIERVAQLKPFFKYIDDANVTRKQEDARRNPNPSSQRAQVVTMSVKSVNDPSQNRLTGSLLAHKVADEEANIELTWAEGTFEQFKDTIVKEAEDKTLVALEKQEDYIDNLV
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSVEKMTKVEESFQKAMGLKKTVDRWRNSHTHCLWQMALGQRRNPYATLRMQDTMVQELALAKKQLLMVRQAALHQLFEKEHQQYQQELNQMGKAFYVERF
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSSEIVSFYTGKNFFITGASGFVGICLLEKILRVIPNHGQIYLLLRPKKGKAINERLEEIKKNQIFEKLLANRSVEDVFRGVQAIAGDVGQDNLGISPEDRRLLVENVNVIIHSAATLDFGDTLKTTVNINLLGTRRITQLAKECRQLKVLTHVSSAYVNSYRLECEEIIYDKPCDSEELISLVEKLSEAELEKQTPEILKDHPNTYTITKHLAEHEIKNCETIFPCTIVRPSMIIGAWKEPIPGWTISKNGPQGFLMGAAKGVIRRLPVGKSLIYDYIPVDVVVNNLLAAGYSAATHNAKQVEVYHCTSSTRNPFSWILIEDRVNSFLHEYPLKSAVWYPYLKFLPSVTWYKISAFFVHILPAILLDFVTRVAGGRPILMKLHRNVNTSLDRLEKFIFTEWKFHATKTTQLHKSLSKTDQELFILDITTLVWLDYFKDLAVGARVYLNREPLKNLAGAKTKDNILMILHLAMQAALFSLIWYLFACIFGMKMSSSAFVVPIGYFVFSLL
The following text describes a protein:
Function:
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVPDPARPAASPSARPRVLVANDDGIFAPGIKALGLALSEWADVVVVAPDVEQSAVGHGITIRRPLRFKHTAAAGFGDIPAYRVDGTPADCVVLGVHLLGRPDLVVSGINIGPNLGEDLTHSGTVAAAIEGLTLGLPSIAFSQFANEAGEYDFGPSAAYASRLAREVCCRGLPPRVLLNVNFPRVSPRGVRVTEVGLHRWEDSVVTRQDPEGRDYHWVAGVSTAHDGHDEQTDYGAVQAGFISVSPVRLDLTARDLIGELTQALPPL
The following text describes a protein:
Function:
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTLNTNDKDLPIVKKYDSLNGTWDFLKTGVSQIFERLDEGMTITKYMELYTAIHNYCADASKTITVDNFNDQTANVLGEALYNNLVLYLEEYLARLRKECISQTNHEEQLAAYAKYWTRFTTSARFINHLFGYLNRYWVKLKNRFTETLVYDIYTLCLVSWHHHVFSHIRDSLLQNLLYMFTKKRLYEPTDMKYVEVCVDSITSLSFDKTDMTKPNLSSYKTFFETNFIENTKNFYAKESSEYLASHSITDYLKKAEIRLAEEEELVRLYLHESTLKPLLEATEDVLIAQHEEVLHNDFARMLDQNCSEDIIRMYRLMSRTPNGLQPLRQTFEEFVKRSGFAAVAKIVPQVGGEADVDPKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTAFRELVNRNVVCQRSSSRSPELLAKYADSILRKSNKNVDIDDVEDCLSSIIIIFRYVEDKDVFQNFYTKLLAKRLVNGTSNSQDAESSMLSKLKEVCGFEYTSKLQRMFQDISLSQEITEAFWQLPQSRAGNIDFSALVLGTSFWPLSPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKLSWLFHLSKGEIKARINPQTNVTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDFLTGILNIFLKAKVLLLGDNDKLGDPNSTYKINENFRMKKIRVQLNLPIRSEQKQESLETHKTIEEDRKLLLQSAIVRIMKARRTLKHVVLVKETIDQIKSRFTPKVSDIKQCIDMLIEKEYLERQGRDEYIYLA
The following text describes a protein:
Function:
May sustain the structure of the postsynaptic density (PSD).
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MWTGGRRPGRLRRAASAADMEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELDKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRAMSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQQRVSLHMEKHGCSLPSPLCHPSYADSVPTCVIAKVLEKPDPGSLSSRMSDASARDLAYRDGVENPGPRPPYKGDIYCSDTALYCPDERDHDRRPSVDTPVTDVGFLRAQNSTDSLAEEEEAEAAAFPEAYRREAFQGYAASLPTSSSYSSFSATSEEKEHAQASTLTASQQAIYLNSREELFSRKPPSATYGSSPRYAKAAATLGSPLEAQVAPGFARTVSPYPAEPYRYPASQQALMPPNLWSLRAKPSGNRLAAREDIRGQWRPLSVEDVGAYSYQAGAAGRAASPCNFSERFYGGGGGGGSPGKNAEGRASPLYASYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPSRSADPLPGYATSDGDGDRLGVQLCGPGSSPEPEHGSRDSLEPSSMEASPEMHPPTRLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN
The following text describes a protein:
Function:
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
Subcellular Localization:
Cell projection, cilium. Cytoplasm.
Sequence:
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMNF
The following text describes a protein:
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MWSSLLDPNGVIRERSGGVPIWHRGSESSVQCGSRVPRWSVGMPPSAAETLRAWLLSALVVHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTSDVLRVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYHQGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKTPLTHIDELRKGAAGSKHMISNNTALKRAWADNRAAPQIYDHHMAITADGNYEVTLMTKATVYYNGLVVWQPPAVYKSSCAIDVEFFPYDVQTCVLKLGSWTYDGFKVDLRHMDEKAGSNVVDVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMSPWVKRVFIHILPRLLVMKRPQYVFETNSRFLMRGREPSTCLYPYHTTVQRDDCSPKRRYPTRTPSKEDLSPSLEDGGPFGGSCQIHGPVAIPHSESEDLTVSAEADNGIKSPVLRNPGFSHSRCPPEIHKSCFCVRFIAEHTKMLEDSTKVKEDWKYVAMVLDRLFLWIFTLAVLVGTAGIILQAPTLYDDRIPIDKKFEEYTTTTVVRCPPPQ
The following text describes a protein:
Function:
Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATRKAAKTKANGPAHVPSGPSQVLAVVYGTLLLVYLRFIFSAGITHDPAKVMTQALPGLLLLHMGYCVVVLGNKPGRKIGTDVSTAMIAAALSVFFSVIIFGLLVLFGAPAISLVHNTFVCAMHMSILAVLPLFFTYHLDSKVWADIIAMRRPLDHVYAASVCTLIGAWLGAIPIPYDWDRPWQQWPITILAGAYLGYFVGTLGGIALELTKSLCSKTKKTE
The following text describes a protein:
Function:
Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSFHKNSSYMEDPDYPGYSGSQNHTQNYLRTQDDLEFPGCLDNPGFHHPRRNPYSSDSRTNPDYHHSLAEPDYPGSPSDADYQNTRCHPRSAHPRTRPDYEPDYEPDYNDFQSESYHPDLSMEPDYPGSHGHPGFAGVRSSVNSTGPRTNLGYLDLEEPDYPGAQGNSYHSGPRSHSNLPGSRRNAGYAGSRINSYPDSLGEPDYPGAENQPNSPDFYGKPDYPGAEEGDVYSPSKTLGVIGRSRGSFGILGREDGDYPEGIEMASLGMAGDPRNGYVNPAYMRGSSPVCPDRNLLLCARDWNTSPQGQKLIASLVPMTSRDRIKTIRNQPRTMQEKRELRKIVDKEKNKQSHGTFEANCCAQCLSSLSLAYRRTKSSLSELLNYISLWQKRFKVIGGKFGTSVLSYFSFLRWLLKFNIFSFVMNFSFIIIPQFTVGEKNTLQFTGLEFFTGAGYFRETVMYYGFYTNSTIRHRMGGASYNMQLAYIFTIGACLVICFFSLLFSMAKYFRNNFINPHIYSRGIAKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSEIRQENDRLTLNQKLTRFSVHVAAWLVSTGITAACCVAVYYLAEYNSEFLKTHKNPGAVLLLPFVVSCINLAVPRFYSMFRLVERYEIPRQEVYVLLIRNIFLKISIVGILCYYWLNIVALSGEECWETLIGQDIYRLLLMDFVFSLADSLLGEFLRRLIGMKFITSLSLQEFDIARNVLELIYAQTLAWLGIFFCPLLPFIQMITLFIMFYVKNVSLMMNFQPPSKAWRASQMITFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPSFIQSIYSWIDTLSHRPGYLWVVWIYQNLIGSVHFFFILTLIVLIITYLYWQITEGRKVMIRLLHEQIINEGKDKMFLIEKLTKLQDIERRANPSTLVLERREVEQQSPLHLEELDAAPDLRLRRSMQEENAIA
The following text describes a protein:
Function:
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
Subcellular Localization:
Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGTRLAAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLLKSPGLLAVPPEEMAASAAAIMSPEEELDGCEPEVLSKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEDDELYRQSLEIISRYLREQATGSKDAKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSFSRVMTHVFKDGVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
The following text describes a protein:
Function:
May be involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNIEGDDEEFYNFNDIKKKRKFTKEDAIYGVFNDGWGDYEDEEESKMTEEEYYKMKKRYSTPVGFVASGIYEPNEHKLKNKDGENIDNDDDDGEEKKKKKKEKKEKKQKKKEKKEKKEKKNKKKNKYGGGGGNNYDDSDNDKSIEDKPVGGIGAALLSKMGYKGTGGLGRDGGGMVEPIKVQVRPKNAGLASVTELNVNSSDDSDDSDQSEGDTDSDNENKRSLGWKKKEPKLKYDFDEHLESTTTTTFKKKTTTTTATTTTSSTPQIVIDMRGPEARLYTGMEEIKHHKHHHHHQHNKEYQNITSILDDQSKPLSELKHNVDLLLKLKQIDIQNQDNKIKHENDKINNLTRGVEKLKLTIENDKEQIKKVTEILETITTVKKQLDQSQLDLKQLYKVFKKLKSNYPKEYQNFKLYNLQKELLEPLLKEKLNQWELESNSDNNDNSSLEISKKLSKEMVKWRQLFQESVSVLGEYQINVYFLIMRDLFLPKFKNYLRSQWDVKKPSNAATLISTWSDTLPDVIQEALLEQSILPKLKVAIEKWDPRTDPIPLDHWLLPWIPLLGSELESFYPLIRQKIISALQDWHPSDKSAIKILTPWKNIFQSNSMDSLLNRAIIPKLSKSIKDLEINPSNQKSPIEIQWLLRWSNLNNNDNNNNNNNNNNNDNNNNNNSITTTDNINLDSGLITLSTIICILEKDFFTRWLKILLEWLKSPDANLEEISNWYSGWKKQFPKEIISNDKIKSIFNISLNLMKKVLSNETIQKDDEILISQKINSLLNTNINNNNNNNNNINNSYQQQNQQQPIKPISSPSLNSSNNNNIDNISTKQMVEQLAIKNGLLFIPSEKKTNSGQQIYIFDKIPIIIERDLIMYNNNNNNRWEPANIQYLLDKSLNK
The following text describes a protein:
Function:
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Multi-pass membrane protein.
Sequence:
MENGDGGGRAPTPAGLPYYVALSQLLGLASVAATGAWLGLYRGGIAWESALQFNVHPLCMVIGMIFLQGDALLVYRVFRTESKRTTKVLHGLLHVAAFVFALIGLVAVFDYHRKKGYADLYSLHSWCGLLVFSLYFIQWLAGFSFFLFPGASFSLRNLYRPQHVFFGAALFLLSVGTALMGIKEALLFGLGTKYSLFPAEGILANVLGLLLLSFSVVVTYILTRPGWRRPPRPEEQALSMDFKTLTEGDSPGAGQ
The following text describes a protein:
Function:
Together with PDP1, PDP3 and PDP6, interacts with MSI4/FVE and MSI5 to suppress FLC, MAF4 and MAF5 expression by regulating the function of the PRC2 complex and modulating H3K27me3 level, thereby promoting flowering.
Subcellular Localization:
Nucleus.
Sequence:
MSTESERIESVSEANASSLEVGNDQMSEALAGQAQELKTIGDDKEGCGNFASAGDNGMEKVNGFTNLVKETESVNGELDLGTRTENVGGESNQSDKKVLVDSEEVMMVEKRGLLVEKEVEPDMVCSHGADLSDVKVSDGRLDSEDLVQDRKPDGLEKQGTKVEDLDVVCFMGLEPHESKDESILDDEIAHVAAKVKISDSDLVWAKVRSHPWWPGQVFDASAATDKAKKHFKKGSFLVTYFGDCTFAWNEASRIKPFRQHFSQMAKQSSLPDFIDAIDFALEEVSRRIEFGLACSCISEEVYQKIKTQNVINPGIREDSSSIHGGDKVSSAVFFEPANLVGYVKRLACSPSYDATDALQLVSQRAQLLAFNRWKGYTDLPEFMTLQGSVESAPKISPAEEQSSLVEVSDPEPTKSKQVYTKRRKTNLQTEQSSLVEVSDPDKGDCKHDGVFEYEETIVPKKKEKTLAEFIAEKRVSRHNGNTSHEKSGNVPHCEKKRKVVQSKVPKSTKKIKANLQTEDPGSPVSPKNDRKNNLSAGDKITPQKARKSFGIGASILKVANQMHCSTPTRLLPCSDSTSKKAAKSNGSGKSLQEKPKAEALSAREISPSTTLSSPHAASVTKTTSGKSNSVSLDHNLSGELDQVRKEAPSTNLVEDPMLESRDLKDSSKEQVVHEDKKEAANVADEKSIMDSNLTGEKISGLDLREQPSNKNCSGGSDSCKEDVSAE