lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MRRVLEDNGGDGSSVRDFSFFTTERGDTLFTQSWTRVGSVKNRGLVVLLHGLNEHSGRYSDFAKQLNVNGFKVYGLDWIGHGGSDGLHAYVPSLDYAVTDLSSFLEKVIAENPGLPCFCVGHSTGGAIILKAMLDPKIESQVSGIVLTSPAVGVQPSHPIFGVIAPFLAFLIPRYQLSAAKKKIMPVSRDPEALLAKYSDPLVYTGFIRARTGYEILRLGSHLLENLTRIKVPFLVLHGTADTVTDPKATQRLYDEASSSDKSIKLFDGLLHDLLFEPERGIIADDVSLLVLLLDTNPFFWDTTSTTFSQFLSHVLAFLNAVLGLNQLNQVVVIATGYSSCDYVYDSSLTSNILCLQGSPDGPEQSVFGQSKLDGANASSSVNDRKRKAPDS
The following text describes a protein:
Function:
Required for 27S rRNA processing to 25S and 5.8S.
Miscellaneous:
MISCELLANEOUS: Present with 6960 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
METSNFVKQLSSNNRKTRVNALEALKKYLTAKQFKENKQIEFNKLWKGLYYAMWFSDRPRPQQRLANELGELHGLYFDPKDNSTADELTTNDKAFIKFSRGFWKVMCFEWFNIDRYRLDKYLLLIRRVLFSQLKYLQSRNWDKKLVDEYIKKVLRWLPLSGSPKVYTGIPIHIVDILLDEWERLLKDGDEDDEDEENKEEEMRKIAESAKKTPLADVIAIFQDIVADYNNSKVLREKIKEDLFSDTRLVSWDILEGETQHNDSSNESEEEEEEEWKGF
The following text describes a protein:
Function:
Has a dual role in the assembly of mitochondrial ATPase.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MTESKLTPTELSPTGPPTTVTASAGNTPINNETSFDRWNRKLRMTTGLGLKSSEEKQEWLLSRCRGWKDDLVETSPVIRYLLQHISTLPVPDSQPSSSEASRPTRSIPIPINCGICSPMRSAGLFSPNEPDPSSPTGGQVKLCADSLASKAHLEDVLSHELIHAYDHRRFDIDWTNLRHIACTEIRANALSGDCKWTREVDRHNFNFARQRQICARRRAILSVAQHISAGSQPSGSGDQATSSKTLASEQAEKVVDQVWSSCWSDTRPFDEIY
The following text describes a protein:
Function:
Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
Subcellular Localization:
Nucleus.
Sequence:
MPSNPSLEAVSAANATKRKNAPRDDEDSASESGSDVSMINVDFDFYNLNPDVDLIAVKRLLRQTLSYDEERIDVHSLAELLLAEGVRLQAGSSIKTDGEESDPWGLVAVIDIVRHKDHPALKPFLDYLGSVMANSNSPLQSVFSPSSPNTRPALVFSLRMLNLPLPLIPHLYRMLLEELETKEEGRFTHFLVWGRGYRLEGTEEGMGLDMNVVEKSSKKKKALGNETVALSAGSFPYHPEEEFMDKVASQVHTYNFKTAAPRDAESFGVEQFGRLVLLEKAKLVSAIQSMQAACQ
The following text describes a protein:
Function:
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MLEGTFVLMRFPQVIPVHWLCCQVASAQHPNPLHPKPTQPQPAGSSSPTCGPRIGPDFAAGSPPGPSSASTMRWATILLVAGLCRASLGQYNEEEDLAWLQYYMRQSRMSSYNYMPYYEDENSPYVYSYVPAPDTEAEPVPEAQQASSWQCPQECDCPPNFSSAMYCDTRNLRYLPFVPTRMKYVYFQNNQITAIQEGAFDNATELEWLALHNNQISSEKMGKRVFAKLKNLERLYMNNNNLTKMPSPLPRSLRELHLSYNQISKVPSNALEGLENLTALYLSHNYIFEMGASLKGLKSLILADLSYNHLRKVPDGLPMALEQLYLEYNYINAIPDDYFKVSPKLLYVRMSHNSLTNQGLSTNTFNSSSILELDLSYNRLQKIPRVSTNLENLYLQGNQINEFSISSFCTVVDVMNYSRLQVLRLDGNEIKRNAMPPDAPLCLRRATVIEI
The following text describes a protein:
Function:
Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
Sequence:
MQGVVDDDPPYVFVVFGASGDLAKKKIYPTLWWLYRDELLPKNVNFVGYARSALTMEKLVGTFEKHCKVQDSEREQWGRFLKKCAYVQGAYDDDKGFKCLQRLIDAMQAEASNIPVNRMYYLALPPSVFADVTTQLKENCMDKGDSWTRVIIEKPFGHDLQSSRELSNHLAKLFKEDQLYRIDHYLGKEMVQNLMVLRRMVKRCGVCPRPVSLPMRSFPVNSLPEKQSMWIRRLNLLPEEGDALLQQFREGLAKQPPVRTYWCPAHFDGDQPDPIDKTLGLPNITAPLDMPLLTRKLSEVAVRDCNVSVAPPSRMHSLTLFSQSSIPPIESENDQSNDYNSQEFDAGDYSSQETTTDSVDESTSLELPEFLLIESSQLLSLFDRCPSCGLKAIVSRSFTLNGSAVRIAWDCEHCVTPQSWRSQSLLKGRYYHGNVKLVTAAHTTGLPFPIVNKHKKEIGINNVSGRMEKAGVREGLRRIQAMQLRIRSVCTDNDAKLGKMLREDVLFKDIQHLLDFWHLIKSINHDLREIAKKRSCGNIQYWRRKIINHAYFLHFKYAKSRQLGLNYWKAVLPHVTGRHTNLGKIPFLDGIRRCKHKRLQPSTLHQIKRDSDEYQELKAVIMKPTFLAGFLRASPKKNTSPNECFNSIINLYAPKSRACSPRWYSERVKLATLHSNTLAILNLLNLREEKGNCSVNVLGRESNAVKRKMAKADHAWRREIWEAIPAVIEGRLMEQFLKRINAPNDREYMLAMQQEEEENMDEGDEEEGEGEDGGESDVSEELGGGVYGEEVDSDHEPAMNTIELSDAEDEESEEELVEREGEEGSGSDWDEGEAALRALERGGRGRGRGRGRGRGRGRGGRGGRGRGGSVAVSVAAGKSTTVQGEGQPPEEEKGDRREKKERRSKTARKDMEEERESTDSDYDQPPVKKGRGAGRGTKCQGTMQVGELEYMVVNVSKSQIYNTSWRLHFPKSWTSGRSLSSSEAGATSTASLTSTAHSSAIFGNRMFNPSWNRDNIGSVLITFKEDFGTEGRAGYFDQSGIIRDVMQNHLMQILTLVAMEKPASLNAEDIRDEKAAKKYEGPKENPSRKLGYKDDKEVPPESKTPTYAQAVLHIHNERWEGVPFILRCGKALNEKKAEVRVQYKPVNGDIYPAGELKRTELVMRVQPNEAVYLKMMTKKPGMGFGVEETELDLSYAQRYKDTRLPDAYERLFLEVFMGSQINFVRTDELDHAWRIFTPLLEKLENVKPTQYKFGSRGPAEADEVMRKHGFVFTGTYKWTPSK
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MENSAADAAAAAGGADVIYISSDDEDEEIRILSADPYSPEEIQIQEVILLSLDYSRAAAADADTAQSSASSSRPSAAASTFGEPSSLPDRKGKSKLLSEESVGCNADGPSESTTTRRWRKRGFTCIICMDKVQASEEFLVNVCSHAFCKSCIGGYVAAKVSDNVAAIGCPDPGCEEGSVEIGQCRDIVPPELFGRWSVSLWESSMGETTKCYCPFKDCSAMLINDNGDGGDAEEIAETECPHCHRMFCASCRVPWHDGIDCKEFRKLGNDEKGKEDLMLKKLAGKKKWQRCPQCRMYVEKSAGCTFMRCR
The following text describes a protein:
Function:
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (By similarity). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2). Essential for definitive hematopoiesis and pancreas morphogenesis.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Colocalizes with pre-60S rRNP particles.
Sequence:
MTMKVHKVHSRSQQRQRNASKQHGKNKWNKKVRSLDSTLLNTSSGTAKLEQEIAKKEKPAIKRLKKLYAKPVTLLSDNNCADEDKVKPTSVTFAHVHTNGGTELDDSSRSVDSQEWSEYANSVLQNGMETSTLPDSDQAEDGLQFHAHLDHTKNRAVLVMKQSQVLCFRGKCLLTCLYGHVEVLGFTIEEGQQPYPVFSPPTHCPLTITALGNNQSSSKNKKEGQLEAKAIVRKYFTTEPSKKLMNEVDSDSCVVLLESLDTPLTRFLSSFSELTELFGLNSKELKSQAAIYSPVLSAVGVTALRGPCAQGLVMSRSYKETISSLLSAWAGEFDRCPIILVCGGKSSGKSTFNRHLINSLLNHTASVEYLECDLGQTEFTPPGCLSLCTVTEPLLGPPFTHLRDPEHMVYYGQADCQSDIDRYLESLKSLWRNVSGESPVIINTMGWIRGHGFQILVDLVRLFSVTHVVQLSYGTAPQCQLLTSEFIRSAHGWQTHPPTTPALTEDSHSPSRSHVFLSVQSEFEGAGVSGEMRFQRSNELRDLALLSYISKLQSSDPGPIRPLHCFIPYQVPHSSVAIGVTHCEVAPNNILYAANASVVGLCCLSEKVVGRGGPVILSQTPICQCVGLGVLRGVDMGRGLYFLVTPVSPSVLKHVNCLLLGEISLPKILLTQQHGVEGDLPYITTDYSFEVQGAGKLHIFKGLTRPGFIKSDN
The following text describes a protein:
Function:
May act as a catecholamine-responsive trans-membrane electron transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
DOMON domain could bind catecholamines and thereby could regulate the cytochrome b561 domain function. DOMON domain could bind one heme b.
Sequence:
MCDQRPNLLGSLVLLGFFIFFVNGEECSNSSSLIGHESEFKMLQHQLRGVFTVVDDCSFRVSRFDMLSGSEVHWWGAMSSDFDNMTNDGFVISDQKLNQTFKNSSFIVRLLGNVTWDKLGVVSVWDLPTASDFGHVLLSNATESDTSKAESPPSESNDVAPGKSNNSEPFKAPTMFDNCKKLSDKYRLRWSLNAEKGYVDIGLEATTGLLNYMAFGWAKPNSTSNLMLNADVVVTGIREDGFPFADDFYITESSVCSVKEGTATGVCPDTVYEEADSVGSSVNNTKLVYGHRIDGVSFVRYRRPLNDSDNKFDFPVNSTESLTVIWALGVIKPPDVINPYYLPVNHGGVESENFGHFSLNLSDHVDECLGPLDADNKYDQDVIIADAHAPLVVTAGPSVHYPNPPNPSKVLYINKKEAPVLKVERGVPVKFSIEAGHDVSFYITSDFLGGNASLRNRTETIYAGGQETHGVLSSPSELVWAPNRNTPDQLYYHSIFQEKMGWKVQVVDGGLSDMYNNSVNLDDQQVKFFWTIVGDSISIAARGEKKSGYLAIGFGSEMTNSYAYIGWFDRNGTGHVNTYWIDGESASAVHPTTENMTYVRCKSEEGIITLEFTRPLKPSCSHRDRPECKNMIDPTTPLKVIWAMGAKWTDGQLTERNMHSVTSQRPVRVMLTRGSAEADQDLRPVLGVHGFMMFLAWGILLPGGILSARYLKHIKGDGWFKIHMYLQCSGLAIVFLGLLFAVAELNGFSFSSTHVKFGFTAIVLACAQPVNAWLRPAKPAQGELISSKRLIWEYSHSIVGQSAVVVGVVALFTGMKHLGERNGTENVDGLNLALGLWVFLCVVTVAYLEYRERGRRRARNLSRGNWVLGNVEEDDSIDLIDSRGGFRDKDDEDRNGGRMEIQLEPLK
The following text describes a protein:
Function:
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
Subcellular Localization:
Postsynaptic density.
Sequence:
MSQACPEGFCILFWNADRGGGQVGGPFQSGCCFVRFAGDSFKLSPDVAHSRQQVDFLGPCAGGGSRSALVQLRGQTSVFRKQIHCILGGEVLAVADAVSTPAQHLQGAHHVLGSVLVTCILSLAPDSGAGSTLTQATWRLDITEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MPPKSTTAAAAAKNQQQQQNNNNQQTNKSQNELELNSKAQQQKKKTDQETTRMAIEQFAESVHLVESFADTLDAIPPSLTRSLSDLKELDAVLTTPLNQLHSRLDQLIHSLKQPKSINPQQRLQLLRSIISDIERYRLGAQDKIRVANGTCESLSHHIRQLDTTTSLLISSLPPSLESRIPPSTFPTGYPKLTGSLRSKPIGGVWQNSNPSNLQQPSPPSIPAREFINFYQGSPGRQINSQRPFDPHQPLSKRPRLGASGQSHQAGDDPSLLRRDHQAETGSKLLDQHIYSQSVLDKHRTIHEDNHQPSGPPRPGGKTASLARQHSQIGLTSPNPSLNAPVSKNKRSRISSGLAEPETEDWSNPSPKLNPASQQAGAVGPKKRVRKSNPAGSVAKNAPAQQADELGSSAKPSELKANGLPSTASTSPSSHPTKSTTVAPVGGAGRKAVTGVRQTLTKADGPAGAAAPAPAKRAYTKRSGLTNPGTAAGGPKGKRANAKKAVGGTTEGGSGEAAGKEPATRKAEGPERGRKAATKETVRLDDVAEAGAKPRQRKSALHDPSQADQSASARRDKEARNSFPSRDPPEFDSLNRPAHEDQLAAVSNGDPTSSRLTKTQSAAPSRKRKNHRSYDLDQSVQVEDGHSSDGSNHSSSTKAYCICKGEVHGDRMVACDNSECPIEWFHYQCAGLTEDPTGNWFCPDCQAQGFGSTSVCPPGVPSHLEDGPARPVEQQQPVPPPPAAQPGPLPETSFVVPSDDPVVGGRSP
The following text describes a protein:
Function:
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSLFNLDRFRFTKDKRKPDSAVLAEECRSESPDSEKENKTETPEPKRPPSNKQIKGVEFLDSDSEADDLPSTVSDAPSIKSKPVAKSLMHRNQQAGEPNDSHWNTNEVDVETTEERLSKLKEIFPQKDSKQLKEVLKNTSTLDGAVASCMVLFGDEDNARKRKNKDSSKSSSEDRDIVQPSKKKKTAVSSSLFEVDENEAANSMEEWEKQEATLRRLQKKFPNLDKEELRDVLQEHEWCFEDALEALRMFSDPDQDSSSSPEPKVTKEHTVSPDIKTWLSAGERPVARKQNWICRPSESGKNKARVTRVEDSSSEDEESISSDYEKSSGEDSDAEDGLNQEFKAKILTFLQDASVDELSLISQCSVKKAQKIVELRPFKNWEDLIKTFTKANGLTEDLIWGCKDVLKERDVVLGLMTKCEKISKKMTEAVTRVTECGLNTFKQPALLNQRMQLKPYQLIGLNWLVLLHKNKLSGILADEMGLGKTVQAISFLANLYEEGDHGPHLITVPSSTLDNWVRELKQWCPALKVLVYYGSVEDRRYLRHDILNKEVDFNIIVSTYNLTISNADDRSLFRRLKLQSAIFDEGHMLKNMNSLRYKHLMTINAKYRLLLTGTPLQNNLLELMSLLNFVMPHMFSSSTSEISRMFSMKSFEEQSTFERERIAHAKQIMKPFILRRVKNEVLKQLPSKEEKIEFCAMTEKQGKLYSALFEKLKRSVNGEKKELCNVMMQLRKMANHPLLHRQYYTEDKLRQMSKLMLKEPTHHDANPDLIFEDMEVMSDFELHNLCKQYKSLCKFQLDTNILLNSGKFQVLEDILAKIKVKGDRVVLFSQFTMMLDIVEVLLKHLNLRYVRLDGSTPMADRIHLIDDFNTDTDIFVFLLSTKAGGLGINLTSANVVVLHDIDCNPYNDKQAEDRCHRVGQTKTVQVIKLISKDTIEDCMLKVSQKKLKLEQDMTAAVEGEEGIIPEDMASLLKATLGL
The following text describes a protein:
Function:
Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
Sequence:
MDSPAILPTTRTLCPYCGVGCGLEAVASPQKSVVDAGHAHKIRGDRQHPSSQGMVCVKGATVMESMDKQRLLYPMFRSSLDQPWQQISWEAALEIVVDKIQQVKQTLGVSGLCMYASGQMQTEDYYVAQKLFKGCLGTNNFDTNSRLCMSSAVSAYSLSFGSDGPPCCYEDLEITDCAFLIGTNTADCHPIIFNRLRKHHKQNPHVKLIVVDPRCTATAEVADLHLAINPGSDITLLHGIAYLLKKWNLIDQKFIDNHTQDFEQYCQVIDHYPPEKVTQICGISLEQLETAAHYWGNAKTVLSLWSMGMNQSFQGTAKGRCLINLHLLTGQIGKPGSGPFSLTGQPNAMGGREAGGLSHLLPGYRSIKNPQHRQEVEQLWQISPGRINPEPGLSAWEMFMGLENQQVGFLWIVATNPVVSMPDLERVKKALQQSTFTIHQDAYSPTETAEYAHLLLPAAQWSEKTGTMTNSERRVTLSPAFRSPPGEARPDWEIFAEVGRRLGFENQFNFVDSAAVHREYVQLTAERLCDQSGVSYEKLQKLGPLQWPCRQSDQESQLLSTKRLYTDYKFCTENGRANFCLDHSRGLAEPVDPNYPFVLTNGRLYGHWHTQTRTGHIEKIKKMHPKPILEMHPKDAEKLGIKSQDLVAIKSRRGSAQLEVLVTRAIAPGTVFMPMHWGFLWDDNAEVNSLTHATACPISKQPELKACAVNITPV
The following text describes a protein:
Function:
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
Sequence:
MTKPNSLIFYCIIVLGLTLMKIQLSEECELIIKRPNANLTRVPKDLPLQTTTLDLSQNNISELQTSDILSLSKLRVLIMSYNRLQYLNISVFKFNTELEYLDLSHNELKVILCHPTVSLKHLDLSFNAFDALPICKEFGNMSQLQFLGLSGSRVQSSSVQLIAHLNISKVLLVLGDAYGEKEDPESLRHVSTETLHIVFPSKREFRFLLDVSVSTTIGLELSNIKCVLEDQGCSYFLRALSKLGKNLKLSNLTLNNVETTWNSFINILQIVWHTPVKYFSISNVKLQGQLAFRMFNYSDTSLKALSIHQVVTDVFSFPQSYIYSIFANMNIQNFTMSGTHMVHMLCPSQVSPFLHVDFTDNLLTDMVFKDCRNLVRLKTLSLQKNQLKNLENIILTSAKMTSLQKLDISQNSLRYSDGGIPCAWTQSLLVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTCELRDFVKNIGWVAREVVEGWPDSYRCDYPESSRGTALRDFHMSPLSCDTVLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDDIQICLHERNFVPGKSIVENIINFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLAPIPQYSIPTNYHKLKTLMSRRTYLEWPTEKNKHGLFWANLRASINVKLVNQAEGTCYTQQ
The following text describes a protein:
Function:
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDKLLAWSVKQQQEGTNEPPPDPKLLAQLFGAPDDAQLMVQAMVVITQPDNKLEDKEVAFDNFEMLVENLDNANMMKNLKLWEPLLAQLSSPHPSLQKLAAWVVATATQNNPKSQEALVEQGDAGIKKLVDLTSHDDPEVVVKSLFALASAIRNCDDAYKLFESADGLKKVVGHLKPDATAQVKSKTLGVLTGILESETDLMKPEEKRQVFDILVKELETDDHIPSLERSLHVLVLLNQKGFPFTPEETEQVKKAAKRVEGKLDEEDVKYNEDLKYVNNL
The following text describes a protein:
Function:
Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole and gamma-aminobutyric acid (GABA)receptor-mediated sensitivity to muscimol. Regulates synaptic levels of nAchR receptor subunit lev-1 and unc-38, and GABA receptor subunit unc-49 in the nerve cord, probably downstream of egl-15. Regulates motility. During the formation of neuromuscular junctions at the larval stage, down-regulates membrane protrusion from body wall muscles, probably downstream of egl-15. Promotes vulva induction and down-regulates fertility, probably downstream of receptor let-23. Down-regulates daf-2-mediated repression of dauer formation and positively regulates daf-2-mediated aging. May be involved in the recruitment of phosphatase ptp-2 to egl-15.
Domain:
The PH domain is required for fluid homeostasis; The C-terminal domain is required for fluid homeostasis.
Sequence:
MSIPDENIILEGSLKRCKKYKLFKTKWVEHYFVLHCRDRERNLFAIDEFKTSRKNDLKKRFKLEFVIRVESNLSVSDPSILCTAGGGHQEESMLNCIFGVGFRFENIVKDLYLVAKNDEEMTLWVNEICKLCKLHRQHDEGDSSHAAESSISGMSMSSQSLDMSIIEQQQYAENIPESKQYHRMHHFKSVISHNSLPSNPNYNNLPDPLESSRSETSSMYSSRRTEDDSVSYTSGPPVPPPRTRHTLNRFVKNGQVGRLHMIPASTSMGQVVKVEDAEDSSGETLKLDTPEQYPESVTSSEGFPVYERNGKTLIRRAPPPVDRSNKPKNLRGEEEAGTRYRNLSRNGVNENGNYSATFSSRTSNYQQSETSKRRNLDYFEPTQMIENSSLSTLAATSTRSPTPSDIEYISVDVDRTLAFKQMRRAAQSTD
The following text describes a protein:
Function:
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the interphase centrosome and the mitotic spindle.
Sequence:
MDADMIPKFTTKEEEIDFWKALSLKYKKSYKEAQEELLEFQEGSRELETELETQLGQAEHRIRDLQADNQRLQHELDSLKEKLEYQYAQSYKQISVLEDDLSQTRGIKEQLHKYVRELEQANDDLERAKRATITSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRDTRSEVTRMSAPSSPTPDNDKTDSAVQASLSLPATPLSKNLDNAFTSQTVLANGSTNAALTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQAARKNYVTNVNGNLINGDISNYSHSLHTSYFDKARTVNGLDPGDGTHITAPPRSNSPSGLVLSV
The following text describes a protein:
Function:
Mediates sugar transport across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAEFWISFFSNGCIAVTIIMFATGIPQCMEMMKKKTTKNIPFLPYLITNVNAIGWIIYGKMTVNFTVVFVNTIGAGLQTLYMAVYIFFAADKSKPLVQSSVCGGAAAITWYIITQFANVIDAINVTGIICCTVTIFMFASPLAEINTVIANKSTATISLPLTVTASLCSAMWTMFGLVLHDNFIIIPNVLGFFAAFSRFYLFYKYPSSPGLPHSV
The following text describes a protein:
Function:
Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.
Subcellular Localization:
Nucleus inner membrane; Single-pass membrane protein.
Sequence:
MHAGERAPGSPSEGGEEGRLFGHVTPRRPLRERASQNGSGSNNSSTSNFRFRTSTPHYPRGRQRQKREVRFSEEVLELSAEGPFATPFGKRARMKPRQEREEGLQEEGEEQEDDAPAYRLRSSRLRYPPSPYRRVEEEDEAQEEQRLHEEDQEEEEGGSSEGEEGCHQSPNIFGIADDSKLVRPAIRRSPRTGRNVVLGGRGALRRRRGGRPISLSPPPSIWAHVLLWGFSYGQVKDSTVNKPGSLHSVQKSPDHYQKTDLRAKIQPPILKKLPQKVPKSSTQSDGVYSLFMILILLVACIAAGGWYAFQYTPPHTLESDKALQAFQNQMKELMNNYPSQDKQVWKRIQTAFEKRLNFSQPHLEPAILLLTAAKEAENSLKCLSNQIADAFSSSLSAATIRIDGARKATLDSDTVKFSVDEMLSSGFQGGKKAAVVHRFELLPAGSTLIFYKYCDHEHAAFKDVALLLTVLLEEESLQKNLRLLDVETKVRDFLQMKFTNSNMPGSYNHMDIDKLSGLWSRISHLVLPVWPENILPQEKCLQVE
The following text describes a protein:
Function:
May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MGDVPVQPAHPPQDGHWRHRSLLPAATHMGSGPTMGPAAAVGHAPGSCRCPGADGSLPARVHLLSGATRGMWLCLLLLMAACVPTTTSSPGIKGRVTRSALEYGQRFGLELLRSLLQKEHNVNLQGSYQAPLLGRLNYTVPQIHIHELQMNDSTVDFAEDVGVQLTVHRARIQLNATWQAQLGAWQDSGSLRLRIRDLAVAVLLGLGADEYGHPSVWDAGCDARGTDLRLEFRRGQSWLYNLLVPLLQRTLRQQLNKQLCVEIQKGISRLQDSLKNMRVSAQLDPFAAIDLSLLGQPAIRKQHGDVGLKGEFFGVHGRWQSPFSAQPVGLPELQEPMLLVAVTEFVANTAAFVYFTAGALRRNITAEMLPRRFPLKLNTESMGSFAPQLQQHFPSRPMELHLWARRQPLLSCHPNALHGALFGSAEAFVVLPNATRVPAFLLNIDANVTAKPTIAGNRLGGTVGLQSLSVVQVMSHVGPLQVQKLENMLKFGLWLFGVPWANKRLRPGVPLPTPHGITLLHPHLSLHEGFMLITTDLRYEP
The following text describes a protein:
Function:
Precursor of the major egg-yolk proteins that are sources of nutrients during early development of oviparous organisms.
Sequence:
MRAVVFALSLALVAPNFSPGKTYVYKYEVSLMTGLPEEGLGKAGVYGNCKFLISAIDQNTFMLKINEFSGIWLKDHPYLMSMLPEIMEPETRIPIKFEYSNGAVGKVYAPEKVSDFVLNFYKGFLSFFHLTIKKTHNVYDLQEAGIEGVCNTLYSVNEDVKTDRILLTKTRDMNHCQERIYKDMGLAYTEKCDECQKVSKNLRGSTSYRYILKPVPSGIMIMKADVNELIQFSPFSEHNGAAQTKIKQTLVFLEIQNNPITSIPVEYHHRGSLKYEFSKETERTPLQFVKVTDLQVQIQELLDHLTTHNAEKVTDHAPLKYLELVQFLRLARYEDLEVLWSKYRDTPSHRLWLLEAVPPSGTSAALRFIMEKFQAEDLSVTEAVRTLVAAVHMVTANPESIKLFETLTEDSKLNANPVLREIVFLGYGTMISKYCAESDVCPVEFVQPIQKRLSEAVSKGETEDIILYVKVLGNAGHPSSLKSITKIIPIHGTAAASLPIRVHIEAIMALRNIAKKEPRMVQELALQLYMDKALDPELRMLSCIVLFETNPSMALISTLANAVKSEENLQVASFTYSHMKSLSRSASMIHPSVAAACNVAMKILSPKLDRLSLRYSKAVYGEAYSSSFMLGAAATAFYINDAATFLPRSVVAKTKAFFVGAAADVLEIGVRTDGLQETLLKNPSVLKSGDRITKMKRVIKALSQWRSLPNNKPLASFYIKLFGQEIAFANIDKPLIEQAIALASGSSAQTYSIKALKTLLLTGVSFNYTMPVMYTEVRRILPTASGLPFELSLFSAAVAAAVVKVKPTLSPRLPEDFPLSRLVETDIKLETEIRPSYAMATYAMMGTNTPIYQQFLVSRTKFNSTLPSKVFARLNIKEGDFKIEVLPVTAPENITAGSVETYTVARNIEDPTIERIAPILPNKVLKTFPIQIFSNKDSSSEEISSEIIQEEDLKEDVPLLAKRYCAKYRAIGLKACFKVATENAAFIRDTALYRIIGSQNASFSIKPIEGEEVERLEMEVKVGAKAAEKIIKQINMKDSAGTVLSKLNKILTSNLNRTSSSSSSSSSSSSSKHSSKSSSSSSSSSSRPSGSSSSSNSSSSSSSRSSSSSSSRRSSSSSSSRLSSSRSFSNSSRSSSASSLASLFSAESSSSRDSARRSMQKVNSHRFRKAHKNQVFFVDPESINQKSYNKKTCGNELLDERSVAVVVTVHAVKANKEDQGYQVAVYVDKPNARLQIIIFPLSGSNWKLCADGVLLSKHKVTSKIAWGAECKQYSTMITGETGLVSSNPAARLRMSWEKLPSYVKRSAEKVYDYMPNKMLADLIKSKSANSTRQLSFTVVAESEKSIELIAKTPRRTYYNMTLHLPITLPLQEIKSLTPFEEVTDKVHYVFAKAVAAECSLSNNTLRTFNNRRYKNKMPESCYQVLAQDCTEELKFMVLQMKDATEQNHLNVKIADIDIDLYPKDSEVHVKVNGMVIPLTSLPYQHPSASIEIRENEEGVSVFASSHGLHEVYVNKTSWRIKITDWMKGKTCGLCGNADGEVKQDYRAPNGRLARNSVSFALSWILPAENCKDNSECRMKYESIQLEKKVNVHGQDSTCFSVEPVLRCLPGCSPVKTTSVNVGFKCFAADSTLDPSNIFESSVDLRNSTVAHLACSCTSQCS
The following text describes a protein:
Function:
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MCTLEPVCPVNATICTGTSCLVPRDPFNDILSVVMSVAITVMLAMVMFSMGCTVEARKLWGHVRRPWGIFIGFLCQFGIMPFTAFILSLLFNVLPVQAVVIIIMGCCPGGSSSNVFCYWLDGDMDLSISMTACSSILALGMMPLCLLIYTTIWTAGDAIQIPYDNIGITLVSLLVPVGLGMLVKHKWPKAAKKILKVGSVVGIVLIIVIAVIGGVLYQSSWTIAPSLWIIGTIYPFIGFGLGFLLARFVGQPWHRCRTIALETGMQNAQLASTITQLSFSPAELEVMFAFPLIYSIFQLVVAGIAVSIHYSIKRCRHQTLVEEDGEGTTEDCDKHSYSLENGGFSCDENGNNQNKDKGTKL
The following text describes a protein:
Function:
May be involved in recombination.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MWFKNLMTYRLTKPLDWDLAQLQTQLEDCQFHPCGTQDQSKFGWSAPLRGSDLLYFSVGKQILLIAKKEEKILPANVVKRELDDRIESLEQKENRKLKKVEKQTLKDDVVMNLLPRAFSKNQHTALWIDTENNLIHIDAASSKRAEDALALLRKSLGSLPVVPLAFANEPSTILTNWILQDNLPHWLLALEEAELRGSQEDSVIRCKKQPLENEEILALLQDGKKVVSKLALEWEDTLTFVFNEDCTIKRLKFADTVREKNDDILKEDFAQRFDADFVLMTGILAKLTENLLDEFGGEKARL