lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
Subcellular Localization:
Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Secreted, extracellular space, extracellular matrix.
Sequence:
MRWLLRLTLLFAAVHFCSTAGTSEAEQRSCSECHSNATCQDDGGSPVCSCQPGFSGDGFVCSDVDECAAPGAHNCSGGRCVNTEGSYKCLCPGGYRFAPESGCIDVDECSGPEFGPCHPLATCTNSNGSYSCSCPTGYTGDGVRCDCSPGSCGPGLECVWQNGSRVCSDPCAAYSLLDEYWRSSSYQGGWTCDSNRRGWHRFVGRGGVRMPETCVPVNRCNTAAPMWLRGRHPSSEEGIVNGTACAHWSDNCCLWQTSVQVKACPGGYYVYNLTGTPVCQLAYCTDPSSVEGTCEGCNLDEDCKSVDGNWSCHCKPGFYNSDIGSLDPHLQCGANDIKVSLDKCELESMGFQKIFMYLRDSHCAGFEERENRTSVSVVTPSQEGPCGTTLTRNETHVTYSNTLYLAKEMIIRDTNININFQCTYPLDMKVSLKTATRPIVSALNISVGGTGMFTVRMALFQSESYTLPYEGSTVALSTEAMLYVGTMFDDGDTSRFVLLMKNCYATPTSNATDPVKYFIIRDRCPRGQDSTIRVEENGESPQGRFSVQMFRFAGNRDLVFLHCEVSLCDITSEQCKPSCFRTGYRSGTVINPAHVLNLGPITRTDFQASALSDATRSLGFLSAWPVLLSSVLVVFLF
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MAAPPPTGCFKCGRPGHWSRDCPSSASTNPPAAADAPTNPSHLSGAASRFNAKPRPPAAAVDGEDGKGKKKKERATRPKLTPDLLLSDGGIGFVLRYFPKAFKPRARPGHEVDDLANLIKLYADWHSRLIPYYSFEQFVRKLEKLGAGNRVRVSCLYQELKFFLSRQLDGHCRDMCAFLFVRDVFPNSGIGSPEAVILRFCTNRQSTKTCHCQAEVNMVLKTQFSAPMLRCRTTMALAPWCRKTQIHRWRATTWWIPWKRICLTKSTKTQLISRLVREPARSLRSSRLQKKPTRWRRNPRTATSPSRRRLSSLRRRRHAWRPTGSRPWRERRHGLVPRSSPPRYARCCCLHFTSIVGWLVEMMHHSVVCH
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKPQYLLSSFSIFLLFLHCPNTFAQSPAAAPAQAPAVVASPPAATPTQAAAPHGITNVTKILEKAGHFTIFIRLLRSTQDENRLFSALNDSSTGLTIFAPTDSAFSELKSGTLNTLSDGDKSELVKFHVVPNSYLLPSSRPLSGTVYTDNQLAIYKIEKVLLPKDIFASNAPAPAPVASAPEKPTKAVPAVTVESPAASVDISSALIFTHNLVVGSVGLLASAMFSL
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQLVHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAIELAKRFGDDKATKFVNGVLSNIKSDIEQS
The following text describes a protein:
Function:
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVRAAKEGVGRAVGLGGGSGCQAAKEDPLPDCGACAPGQGGRRWRLPQPAWVEGSSARLWEPATSTGWMDLEASLLPTGPNTSNTSDGPDNLTSAGSPPRSGSVSYINIIMPSVFGTICLLGIIGNSMVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
The following text describes a protein:
Function:
Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during meiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis.
Miscellaneous:
MISCELLANEOUS: 'Shugoshin' means 'guardian spirit' in Japanese.
Subcellular Localization:
Chromosome, centromere. Note=Localizes to the centromere. Bub1 is required for centromeric localization. At the onset of anaphase I, Sgo1 decreases markedly.
Sequence:
MSKASLSPNVEDLKKKQIRQYKEIIRISKAQSIRIKELQLENERLLSENIDLRTTAINLEEQLETVQNENEENKTKLAALLNRFHEETDNFLSKLSLCQQEIQDTFKPVEANLAYDVDTDSEDLDEESVVKDTEEIIEQAQHDVSLRNLSGIEDENIIDDGETAINEQKKREANVFSDTQSAPQLKSGKALPADFENPYNLSNSKPVNNNNEDRVEAVTSENKSIDSAPQEKNHEYEIVSPKSLSNKINNQAAAQRRTEEDNANGVAQEENEGSQEAHFHSRIQSDTVIQSTPTKRKWDVDIQNKQINLASAATNVTGYVSETDSRPNRANSLDSAVLLVQSSNKSNRNGHHISDPNLNSSISLKFAPEDTAHNSLTSQENVGPQVTTTSLSNMTVAESPRTDTPREINGLVDSSVTNGNEKFSVEIMNDSNKIGLNPKSFTDEEREILTLFRNPPMRLSSEPPSSNGFSIAHPNNSPLRPPSLQGILNAEDRPYEIEPSRSSFATNDTGSYNNLELLSSVTNLKSPNENDRVTKTQSRRETKVKRRRKARIQETSEESTVVNEPNEKPDGRSRRERKKVNYALPGLRTKLRRNFDLPSDHVKAKKTRRAPKNSENDSATKTETANITSEAPTTSEVTLENSETLNL
The following text describes a protein:
Function:
Phosphorylates the FHA domains of the ABC transporter Rv1747, the heat-shock protein GroEL 1, and Rv0020c. May play a role in the regulation of glucose transport, cell growth and septum formation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADFGIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPFQHANPAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGHRLGGAGDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVAVREFQRADDERAAQPARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This protein may be a 5' to 3' ssDNA exonuclease.
Sequence:
MENYLEEELIIGGIEINYLYVCKTKLWYFVRGITMEQESDFVDLGKFLHEKSYFGEEKEVQIGSIKIDFIKKRDVIEIHEVKRGKQMEKAHIMQVLYYIYYLNSLGIKSKAILHYPKLKEIKEIELKENNKEEIKRAIKEIEYIKSLKEPPEPIYQKICKNCAYYELCFI
The following text describes a protein:
Function:
Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDITDDIAEEISFQAFDDDCRLLESLLRDVLHREAGPQFTDIFERNRILAQSAVNMRTAGLTDMAELLEKQLASDISKMPLEGALTLARAFSHYLNLMGIAETHHRVREARSTSSLSKSCDDIFDKLIQSGVPPQELYDTVCKQEVEIVLTAHPTQINRRTLQYKHIRIAHLLEYNDRADLSHEDKEMVIEDLAREITSIWQTDELRRQKPTPVDEARAGLHIVEQSLWKAVPHYLRRVSNSLKKHTGRPLPLTCTPIKFGSWMGGDRDGNPSVTAKVTRNVSLLSQWMAIDLYLREVDNLRFELSMNRCSDELAAFANEILLKENASEDRFSDSRNQSSNWNTSKSHIQQTSLPVQLPTNASLPSCADGESHYPMQFPGNIGPKITYQKTVKKEHRNLSAPQSPVSASRSTPFNSNQLQRKITDTQIGRFSFQKLLEPSLPQRAGISPFRVVLGHVKDKLTKTRRRLELLLEDLSCDHDLSEYYMTSEQLLEPLLLCYESLQSCGSGVLADGRLGDLIRRVSTFGMILMKLDLRQESGRHAETLDEITTYLGMGFYGEWNEERKLEFLISELKGKRPLVPRDMEFSPEAKEVLNTFHVAAELGSDTLGAYVISMASNASDVLAVELLQKDARLSVSGLLGKSCPGGTLRVVPLFETVKDLRGAGSVIRKLLSIEWYREHVITNHNGHQEVMVGYSDSGKDAGRFTAAWELYKAQEDVVAACNEYGIKVTLFHGRGGTIGRGGGPTYLAIQSQPPGSVMGTLRSTEQGEMVQAKFGLPQTAVRQLEIYTTAVVLSTLRPPLPPREERWRQVMEEISKTSCDKYRSTVYEDPEFLSYFQEATPQEELGFLNIGSRPTRRKASGGIGHLRAIPWIFAWTQTRFVLPAWLGIGAGLMDANHKGYRQDLEAMYKEWPFFQSTIDLIEMVLGKADIPIAKHYDDVLVSDCRRELGAQLRQQLLTTEKCVLAVSGHEKFSENNKSLRRLIERRLPYLNPIHMLQVEILKRLRQDNSNNKLRDALLITVNGIAAGMRNTG
The following text describes a protein:
Function:
When overexpressed in human HEK-293 cells forms an inward rectifying potassium channel.
Miscellaneous:
MISCELLANEOUS: YdfJ may constitute the C-terminal portion of an ancestral gene disrupted by an insertion of the cryptic prophage Qin/Kim. The N-terminal fragment may be ynfP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=When overexpressed using vectors that provide a promoter and ribosome binding site.
Sequence:
MDFQLYSLGAALVFHEIFFPESSTAMALILAMGTYGAGYVARIVGAFIFGKMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGVFAPILLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSFVAMGTNCGTLSATAIWAFMFFILSKEELLAWGWRIPFLASVVVMVFAIWLRMNLKESPVFEKVNDSNQPTAKPAPAGSMFQSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFNKAIPTDALMISSILGFMTIPFLGWLSDKIGRRIPYIIMNTSAIVLAWPMLSIIVDKSYAPSTIMVALIVIHNCAVLGLFALENITMAEMFGCKNRFTRMAISKEIGGLIASGFGPILAGIFCTMTESWYPIAIMIMAYSVIGLISALKMPEVKDRDLSALEDAAEDQPRVVRAAQPSRSL
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MLRSVLSHLRCTSSLHNLDPPVDGEFGVKGRNPGGWDSSYCPMFDEVTISYRLPHIAAVVRSHEAWGLLLSVTMGHDVKRLGLSCVFLLSVIFVVVDAQLPPDANQPSAFLTPHNAARSRVGVPPLKWSNTLATYARKYAYSQRGKCRPLTHSQGQYGENLFWGYGKAWTPREAVNFWVGEAKDYRYSTNSCTPGKMCGHYTQVVWRTTREVGCASVLCSDQAIYIICSYNPPGNWIGRRPY
The following text describes a protein:
Function:
The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A 5'-3' DNA helicase with DNA-dependent ATPase activity; helicase is equally active with ATP and dATP. Requires single-stranded (ss)DNA for helicase activity; The intein is an endonuclease.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Domain:
Residues 135-197 are required for dimerization of a 1-197 fragment.
Sequence:
MAVVDDLAPGMDSSPPSEDYGRQPPQDLAAEQSVLGGMLLSKDAIADVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRRIGGAPYLHTLISTVPTAANAGYYASIVAEKALLRRLVEAGTRVVQYGYAGAEGADVAEVVDRAQAEIYDVADRRLSEDFVALEDLLQPTMDEIDAIASSGGLARGVATGFTELDEVTNGLHPGQMVIVAARPGVGKSTLGLDFMRSCSIRHRMASVIFSLEMSKSEIVMRLLSAEAKIKLSDMRSGRMSDDDWTRLARRMSEISEAPLFIDDSPNLTMMEIRAKARRLRQKANLKLIVVDYLQLMTSGKKYESRQVEVSEFSRHLKLLAKELEVPVVAISQLNRGPEQRTDKKPMLADLRESGCLTASTRILRADTGAEVAFGELMRSGERPMVWSLDERLRMVARPMINVFPSGRKEVFRLRLASGREVEATGSHPFMKFEGWTPLAQLKVGDRIAAPRRVPEPIDTQRMPESELISLARMIGDGSCLKNQPIRYEPVDEANLAAVTVSAAHSDRAAIRDDYLAARVPSLRPARQRLPRGRCTPIAAWLAGLGLFTKRSHEKCVPEAVFRAPNDQVALFLRHLWSAGGSVRWDPTNGQGRVYYGSTSRRLIDDVAQLLLRVGIFSWITHAPKLGGHDSWRLHIHGAKDQVRFLRHVGVHGAEAVAAQEMLRQLKGPVRNPNLDSAPKKVWAQVRNRLSAKQMMDIQLHEPTMWKHSPSRSRPHRAEARIEDRAIHELARGDAYWDTVVEITSIGDQHVFDGTVSGTHNFVANGISLHNSLEQDADVVILLHRPDAFDRDDPRGGEADFILAKHRNGPTKTVTVAHQLHLSRFANMAR
The following text describes a protein:
Function:
Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Also regulates capsular polysaccharide production. May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSNTESLNIGKKRGSLTIYIGYSPGVGKTFEMLSNAIELFQSNVDIKIGYIEPHQRDETNALAEQLPKITTNFTKHGSHHFQYLDVDRIIEESPTIVLIDELAHTNISRDRHEKRYMDIEEILNHGIDVHTTLNIQHIESLSSQIELMTGVHVKERVPDYFIMSADVLEVVDISPEQLIKRLKAGKVYKKDRLDVAFSNFFTYAHLSELRTLTLRTVADLMSDKEKVRHNHKTSLKPHIAVAISGSIYNEAVIKEAFHIAQKEHAKFTAIYIDVFEKNRQYKDSQKQVHQHLMLAKSLGAKVKVVYSQTVALGLDEWCKNQDVTKLIIGQHIRNKWRDFFNTPLIDHLMSFEHSYKIEIVPIKQIPVELKMNKSPYRPKGKRFAIDMLKMILIQIICVMMGLWIYQLDKHESSTIILMIFLIGIILLSIWTRSFIIGFLAAIINVFVFNYFFTEPRYTFEVYRFDYPITFIVSILTSILTSALLKQIKFQYSITKKQLYRTDLLFQFNDSIKQTYTVENLLINAGYQINQLLQQSITIYVINQSKVIKTIPLQNHIDNTTQQHEQALSWVIKNERQAGATTDTFPGINKWLIPIGTSPIKGILAIDYQSSQVINPYDASILESMLNELSLAVENVTLLKQTRESMLQAERQLTHSNFLRSISHDIRTPLTTIMGNLDILVSHSKDMSIIEKEQLLVHSFQESQYLYLLVTNILSLTKLQSSNVQIKLQPYLVSELVEEIDMILERRHLKKRITVSSSVNLQFIHIDSKLILQALFNLIENAVKHTSTDTKINLSIRYASYEQIEFAVIDEGPGISLEEQQKIFEPFYTGSNKYFKDNQKESMGLGLYLVQTILHKHQSNLQYKPNQPHGSIFYFNIYTDFNEGDV
The following text describes a protein:
Function:
Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome membrane; Peripheral membrane protein.
Sequence:
MVCDTLVYHPSVTRFVKFLDGSAGREKVLRLLQYLARFLAVQNSSLLARQLQAQFTTVRKFLRFLKPLNHLQAAAKFYDNKLASDNVVRVCNVLKNIFFAAYLSLDQVNLLRILKVIPVTVLTGKKIPRWSNWCWLFGLLSGLAMDLRKIQTSHAQIAAFVKAKSQSQGDEHEDHKKVLGKAYQDRYTALRRLFWDAADSFIVLNNLGYLSSNEEYVALSGVVTSILGMQDMWKAT
The following text describes a protein:
Function:
Probably involved in transport through the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSDYPPPNYPPPNHPQYQQQQDETYHVRPDMERQQDFGYYEKPTPSQNFDDSFKVEKPKFNDWPFAIFFWLVVAGFIAVAGITLNALRSTYGFQGGSIYGSGNTFTLNTNTIILFAFIIVMAFILSAAIIVFARLAPKAFIVTGVILNVVLGIGTAIFYFVEKYYSAAIVFLIFALFGAWCYWSSRHRIPLSATILTIVIDVMKMYPSTLIASFIGLIFSAAFSALFSIVIVATYVKYDPNSNNEACSVGGGSCSKGKLIGVLVFVFFAGYYISEVIRNVIHVVIAGIYGTWYYLANSDQGAPKHPALSSLKRALTYCFGSITFGSLIVSLIQLLRQFISILRSNFAADGNGWGVCGMIILDFFVGFIDWLVRYLNKYAYCYVALYGKSYIKSAKDTFDLIRFKGMDALINDMFINTALNLYSLFVAYLVALLAYLYLKFTKPEYNSGGAFYAPVIAFAFLIAGQINRISLTVIESGTATFFVALAKDPEIFQMTNRNRFDDIFRNYPQVLEKITSDH
The following text describes a protein:
Function:
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. Acts as a coactivator together with otx2 to stimulate lhx1/lim1-mediated activation of the gsc promoter in the Spemann organizer. Acts synergistically with lhx1/lim1 and ssbp in axis formation.
Miscellaneous:
MISCELLANEOUS: [Isoform b]: Lacks LIM-binding domain.
Subcellular Localization:
Nucleus.
Domain:
The dimerization domain is located in the N-terminus.
Sequence:
MLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKESFHNNFVSLDCDQCTMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQAPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ
The following text describes a protein:
Function:
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
Subcellular Localization:
Secreted.
Sequence:
MSGFLVGFLPGKVRITSVRICKEAGKAGSSPARRLGAAAAVASSPSRGFYCLGYCEGREGGEDSERKGGGGGEKRKRRSLGIVPAFLRLPRGPAPPCHLCTMHLLEMLSLGCCLAAGAVLLGPRQPPVAAAYESGHGYYEEEPGAGEPKAHASKDLEEQLRSVSSVDELMTVLYPEYWKMFKCQLRKGDWQHNREHSSSDTRSDDSLKFAAAHYNAEILKSIDTEWRKTQCMPREVCVDVGKEFGATTNTFFKPPCVSIYRCGGCCNSEGLQCMNISTNYISKTLFEITVPLSHGPKPVTVSFANHTSCRCMSKLDVYRQVHSIIRRSLPATQTQCHVANRTCPKNHIWNNQICRCLAQHDFGFSSHLGDSDTSEGFHICGPNKELDEETCQCVCKGDVRPSSCGSHKELDRASCQCMCKNKLLPTSCGPNKEFDEEKCQCVCKKTCPKHHPLNPAKCICECIESPNKCFLKGKRFHHQTCSCYRPPCTVRTKRCDAGFYFSEEVCRCVPTYWKRPLMN
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSFDINWNQLTIDDTINQSIKEFLDQQFKNISLPSFISNLAVTDFNLGEIPPEVTIRHIGDPFEEFYEDENNLGVMNEANNDSKDEHLKNHGDGINKDSGYNSQNLDDEDEDDEDDDEDDEDEEEEDEDDYDDHDLGTINEGISLLNFNENSTTPSANSFAGSAAPPLPPPLNPSRDSFHSILHPYGVNSIIGATGAGSETPTNILNQNYLSSRVLPKISVKQKQPHHDDNDIQLIVEINYKGDMHINLLVNLLVNYPSPNFISLPIKLHITDIVIHSIATIAYLKKSVFLSFLCDVDDTFPDFDSNVQTPTSTTGGNFVDYYSNDATINKERIDIVKKIKIESEIGEVENNILRNVGKVEKFLVEQLRNILRDEIAWPSWICIDMNDDDDEEEEEEESEDNDGGNSDLNDNDGKHGDGRTDETEAGE
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Cytoplasmic vesicle lumen.
Sequence:
MRIAFFLLILSIIVGLAYGYSCPKPCYGNMCCSTSPDHKYYLTDFCGSTSACGPKPSCSGKLYFTADSQRFGCGKHLNLCRGKKCVKAKVYDAGPAEWVEKDAGKMIIDASPTICHELTGGSSCGWSDKFEITATVTSLTDSRPLGPFNVTEEEMDQLFIDHEIAMAQCEAEKTCNGFDLE
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCSGNQTSQNQTASTDFTLTGLFAESKHAALLYTVTFLLFLMALTGNALLILLILSEPRLHTPMYFFISQLALMDLMYLCVTVPKMLVGLVTGDYTISPSGCGIQMFFYLTLAGAEVFLLAAMAYDRYAAVCRPLHYPLLMNQRVCQLLVFPFCQSRKILSFFCETPALLKLSCSDVSLYKTLIYLCCILMLLAPIMVISSSYTLILHLIHRMNSAAGCRKALATCSSHMIIVLLFFGASFYTYMLPSSYHTAEQDMMVSAFYTIFTPVLNPLIYSLRNKDVTRALRSMMQSRMNQEK
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSNTILSASAKGATFLILLQVASRALTFAVNQILLRFLSPELLGVSAQLELFSISVLYFARESLRVALQRQAHGTQAIVNLSYLAIFFGTPLAYLLALFWLRSDTPAVPYFVEALIVYCLATFIELLSEPAFSVVQQKLLYKIRASAESTATLLRCVGTCGSAIVASRAGLDIGVLPFAVGQLAYALSLLVVYTYNTWPVSKADRFSLFPEKTPSTKDSPSVLNYFSTPLLRLTGSLTLQSTLKYILTQGDSLLITSLASLADQGAYALASNYGGLIARMLFQPIEESSRNMFAKLCAGSEAKSNNREKDDPKQADEEKQNLAQASRVLTTILRLYGIISLFAITLGPTLAPLLLGIVAGKKWSATSAATVLSTYCYYIPFLAINGVTEAFVAAVATSKELYAQSVAMGVFFALFAGSAWFFIGQLELGGSGVVLANTVNMGLRIIWNTWFVNKFFNQRGSSFKLSETLPSLTSLAPAVIVPTLMQMRPGIGFLRRFGVFGELVSMGAIGGVYVLHVLFFERQFLMDCYRMLRPSRAPAAPQT
The following text describes a protein:
Function:
Interacts with the cell-bound hemolysin. Necessary for the extracellular secretion and activation of hemolysin; Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin.
Subcellular Localization:
Cell outer membrane.
Domain:
Probably a beta-barrel protein.
Sequence:
MIKKITALTLLVSTALSAETLPDSHMMQDMSMGESRRALQDSTREVNQLIEQRRYQQLKQQRLLAEPAAPALPQSAQCLPIAGVYLQGVTLLSPADLSALSGLPEQCISSNDINRLTRELTRLYVQKGYITARVQIVRPNSQGELGLSVTEGFIEKIEGGDRWVNSRLLFPGLEGKPLKLTELDQGLDQANRLQSNTTKLDILPGRQVGGSVIRLRNQHAKPWLITAGTDNYGQKSTGRWLARATATLDSPFGLSDFVSLNANSTLENPAHRYNRAYTLLYSLPYGAFTFSGFASFSSYENHQQLPHNVVKLHGQTQQYGLRSDYVFYRDHDQIDSLSGQLTYKRIDNYFESVRLEVSSPTLTLAELSASHLQILPNGVFSANLSVEQGMPWLGAGRHPSSVHLDSQFTKGKLFANLSQRLRLGDATYQLNNLFYGQYSRDPLPGVEWLSLTDRSAVRGFSRSTQSGDNGWYLQNTLSRSFNLGATTLTPRLGADVGRILPRQDNSGWRSSAGISTGATLRYQRALVDLEVSRGWILSNHATPEDPVQVLARFSYTF
The following text describes a protein:
Function:
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTQNVVIIDTGCANISSVKFAIERLGYAVTISRDPQVVLAADKLFLPGVGTASEAMKNLTERDLIELVKRVEKPLLGICLGMQLLGKLSEEKGQKADEIVQCLGLVDGEVRLLQTGDLPLPHMGWNTVQVKEGHPLFNGIEPDAYFYFVHSFAMPVGDYTIAQCEYGQPFSAAIQAGNYYGVQFHPERSSKAGARLIQNFLEL
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGGGHDDFSSGAFNDPKHRVSGPGLTRTMYSTGIGAAAGTFYGACVAAWYPDPVTTTQKFGGTLGKSDFRAVGRTIARPAMWFSLAAGTFTATECVMEMIRNETQDAWNSLVAGMAGGAVIGLTTGKPQIVAATAIGMGIFTAAMDLSGAKTVHNESMLDYKRHGLLPKVHKESEALASLKEQFPKFKDL
The following text describes a protein:
Function:
Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchanger (GEF) for the Golgi YPT1 GTPase. TRS65 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS120 and TRS130. Involved in cell wall (1-->6)-beta-glucan synthesis.
Miscellaneous:
MISCELLANEOUS: Present with 1660 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Golgi apparatus, cis-Golgi network.
Sequence:
MECFVPLRCDLDGSNIEQLRQSHLSRKFIIFDEQLNLWLWFQGNSQENKRFVLQNMIILINEAQVTRTSTIDDYFTQVENNENLWRLKNDCCSKILFKSNVVMNNGYNNQIKFVFEYKSVDANFNNQDSLQDPQAKYTLDKYSSEEILPSFEPVYSWSSAATKSSKNTNNHLEKNNRATHRVSSKNSEVHEADVSRNPNTFTLKLQYPIFSLLNMRLRNISLKSEHCILSSLDFQTSKASEQLTKKFIYPQEHNSFLKLNFQEISYKLIDGTSQIELDPICPLKVPLTAFSYDSISATFKLVLLPKSTQPHRVKITLAYELELHPNLKLPVRTSWETEVTLKRSMPISSTSSQYSSNNNNTNHSASFNGAANNVNSGGLANLRLGGVSSSRFSLGAASTTSLVNSKLSNVKFKFINSNIKVIKGEKFTMRLQIINSSSSPLDLVVYYNNTINPIPSANNVRNSNGINNCGMNNGTIPNSPLTLENQYQLHNKYRKIAEGIILLSNDYKIPVVPPRETYFADLRFIGIMSGYYGTLSGLKVLDLNTNELIEVGNGASVLIQ
The following text describes a protein:
Function:
Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein.
Sequence:
MNKKCIVTATHILLFLQALSSINALPILPEEPEHDVVHDYHYETSFVTPYEEIDELAHLKWSVDYTTSLLRYMLSVPLFDDVTADDAGSRSENFPALSRAGREWLAVGMSPYGASTDADMVTFIRGSNGEVTILDTYTDENGVLTVDDKQDYKLWNAWIRQPLGEDISDDEDDHRVKRKELVIEYGRQIDTCDDKDYLVERGTTHLLFLRGPGSWPQNDTVESSVAPLHHSLRRVTLLKPERPIPSFPSDTKIIEVTVDDITVPDDDTTYWCKVSKFPDAEVKHHIVKYEVEVTEGNEDLVHHIEVYHCDVDPDVEVSLYQGPCDDRPAGSSSLACSQVIGAWAMGAEAFVYPEEAGIAIGGPTTSSYIMIEIHYNNPARKAGIVDSSGLRFYYTPTLRPFDAGIIELGLVYTPKLSIPPEMDEFILTGHCLPRCTGKGLPRRGIKAFASQLHTHLTGTAVWTKHVRDGIEQPELNRDDHFSSDFQEIRMLPKPVHILPGDTLVTSCRYDTSDKDNVTMGGFSITDEMCVNYVHYYPRTPLEVCKSTISKRILRNFFYWANGHEEDVADDMSDEEIVEGFQSLEWTGETKKVWQEIVHQTNVDMDCFRPAGVPFTGKWNNMEREEIRTHLPQISDECSTTDD
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAQSFDDWLQSLNPVTKGVFAAAVLLTAAISMHIAPYTYFTLDTSAIMGLQLWRPFTAALFFGKFSFPWLIAMAMFVSYLKYNEEYDYQGKTADFAWMLILVVIGLTAGGLLLGLPIVSGALLMALCWVFCKRHPQLRMKLYSFEFDAKTFPWVLALFHFILGQNILEDALGIVVGHLFFFLNDLIPLKHGTNPIATPSWFVRLTGLENGGVRFGGVHAGGQAFAARFARQPPPAAAGGRPHHWGPGHRLGTT