lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2.
Subcellular Localization:
Mitochondrion.
Sequence:
MSARLPLLLRQLGHQQLPPGPACRLRELCRSGSRSSSSGGGDPEGLRGRRLQDGQAFISHSPGSPEDPGMDSIVRDVIHNSKEVLNLLQEKNPAFKPVLAVIQAGDDHLMQNVNQNLAKEAGLDITHICLPPDSGEDEIIDEILKINEDPRVHGLALQISEDSLCNKVLNALKPEKDVDGVTDVNLGKLVRGDAPECFVSPLARAAVELIEKSGITLDGKKVLVIGAHGPLEAALQCLFQRKGSMTMSSPWITPQLQDKLREADIVVLGSPKPDEIPAAWIPSGATMLNCFHDFLSGKLRGGSPGVPMNRLIADESVSLLAAALRVQNMVNSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSLLERLKDQTDGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQTDKALYNRLVPLVNGVRKFSEIQLSRLKKLGIHKTDPTALTEEEVRKFTRLNIDPSTITWQRVLDTNDRFLRKITIGQGSTEKGYSRQAQFDIAVASEIMAVLALTDSLADMKERLGRMVVASDKDGQPVTAEDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSNIQLVADGCCNLQKQIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSAGGKGSVDLARAVREAANKRSRFRFLYDVQLPIVAKIRVIAQTVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHEPDKKGVPRDFILPISDVRASIGAGFIYPLVGMMSTMPGLPTRPCFYDIDLDTETEQVKGLF
The following text describes a protein:
Function:
May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.
Subcellular Localization:
Cytoplasm. Cell projection, axon. Early endosome. Note=Present in axons and neuronal growth cones.
Domain:
The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity; The central coiled-coil region is responsible for association with early endosomes.
Sequence:
MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDAVLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAVKAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPLQESSTRLSLTSDPEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDEDEVSMKGRPPPTPLFGDDDDDDDIDWLG
The following text describes a protein:
Function:
A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration.
Subcellular Localization:
Secreted.
Sequence:
MRIHYLLFTFLLVLLSPLAAFSQKINEPVSCIRNGGICQYRCIGLRHKIGTCGSPFKCCK
The following text describes a protein:
Function:
Non-heme dioxygenase involved in biosynthesis of morphinan-type benzylisoquinoline and opiate alkaloids natural products. Mediates the conversion of codeine to morphine. Also catalyzes, with lower efficiency, the 3-O-demethylation of thebaine to oripavine and of (S)-scoulerine to 3-O-demethylscoulerine. Supports, with a lower turnover, the conversion of codeinone to morphinone, of thebaine to neopinone, and of neopine to neomorphine. Supports dealkylation reactions such as O,O-demethylenation in the metabolism of protopine, benzo[c]phenanthridine, and rhoeadine alkaloids; cleaves a methylenedioxy bridge leaving two hydroxyl groups. Catalyzes the O,O-demethylenation of methylenedioxy bridges on protopine alkaloids such as allocryptopine, cryptopine and protopine. No activity with (S)-reticuline, salutaridine, papaverine, (S)-corytuberine, oripavine, pavine or noscapine.
Sequence:
METPILIKLGNGLSIPSVQELAKLTLAEIPSRYTCTGESPLNNIGASVTDDETVPVIDLQNLLSPEPVVGKLELDKLHSACKEWGFFQLVNHGVDALLMDNIKSEIKGFFNLPMNEKTKYGQQDGDFEGFGQPYIESEDQRLDWTEVFSMLSLPLHLRKPHLFPELPLPFRETLESYLSKMKKLSTVVFEMLEKSLQLVEIKGMTDLFEDGLQTMRMNYYPPCPRPELVLGLTSHSDFSGLTILLQLNEVEGLQIRKEERWISIKPLPDAFIVNVGDILEIMTNGIYRSVEHRAVVNSTKERLSIATFHDSKLESEIGPISSLVTPETPALFKRGRYEDILKENLSRKLDGKSFLDYMRM
The following text describes a protein:
Function:
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGAVLPEQYQEDASDVKDMSKYKPHILLSQENTQIRDLQQENRELWVSLEEHQDALELIMSKYRKQMLQLMVAKQAVDAEPVLKAHQSHSAEIESQIDRICEMGAVMRRAVQVDDNQFCKIQEKLAQLELENKELRELLSISSESLQVGKESSVAPEAQTIR
The following text describes a protein:
Function:
Probably acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes in order to regulate various neurogenic identities. Specification of some neuronal identities also involves expression of non-Hox genes. Specifies dopaminergic and serotonergic neuronal cell fate, and regulates neurotransmitter choice and axon pathfinding.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDTTNQSEDIKPCDSDLMESILMFDEPISDILAHNKLWISHARTRSNFFPQEGRHISNQHTEAATSLKMWMLSKNLVVIVKRKDDIFPCKILTRNPENLFVARFLESGKEKHIQVEYSDIIMTRSELEKALPLCQHLIPARNWDDFYIIRDFEKATPYFEQGLSALVKPGQQFELQLEDAPDFYVMATVVKNYRGFLLVEYQNFKRWIHMLSPYCHEIGWGKNEKQEYLKRGPYNRHMNVDLVAGLVKQSTNQKLGAVPEIVFRNNCPVPHRIPEYSACVYLDLDQKRFYFAHKVTTKTCRNNRHFFNISIGKNLVTSKQNNRPYEFHVYHPRILPYSVAKRMEVQIILPPDVKLLPDESNLDGYLRTYCNPCDKHKTSDRVQPSPKIAKKKNGPLLLDDTPDAMFRSRPLLGDNIGAHKEWTNFMNHIPDYKRKDLLKSMDTLKFCEIFRPTPTGALQLTAAEVTGQQECMLRLKVSGEDEPVYIHNADPHLYHLGACLDMELAINFHGEFFDEKPLKKNKNANNGFSSF
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MYDVILTIVITATVQGCFGYQDLFPYRIPTPREPVINSNTVCGNVPGLTIRQSLVCARDPHAVASAIQGMQLAIHECKRQFKNNRWNCSSLETKNKIPHTSSFLRTGYKETAFSYAIASAGVTHQVALACSLGKIDACPCQRPKKSHLTASERRNGCSHDINFGLQFSTQFLDSRETAHDFMATARLHNNRAGRLTVAGRMRRQCKCFGKSGSCDQKICWDETPDFRMVGKILKKKYDEAVVVGPLNRLNTVRDNSLRLVHEKPSYAAGDLLFFETSPDYCRADPSINILGTSGRYCNATGGRKQQDSCVNLCCGRGYRTYTETRTEKCNCRFHWCCFINCDNCTYTEDIAICN
The following text describes a protein:
Function:
Involved in the biosynthesis of albonoursin (cyclo[(alpha,beta-dehydro-Phe)-(alpha,beta-dehydro-Leu)]), an antibacterial peptide. Catalyzes the formation of alpha,beta-dehydro-Phe (DPhe) and alpha,beta-dehydro-Leu (DLeu) residues during the biosynthesis of albonoursin. The catalytic reaction of cyclo(L-Phe-L-Leu) occurs in a two-step sequential alpha-beta-dehydrogenation leading first to cyclo(alpha,beta-dehydro-Phe-L-Leu) and finally to albonoursin. Can also use cyclo(L-Phe-L-His), cyclo(L-Trp-L-Trp), cyclo(L-Leu-L-Ala), cyclo(L-Phe-Gly), cyclo(L-Leu-Gly), cyclo(L-Ser-Gly) and cyclo(L-Glu-Gly) as substrate suggesting that the diketopiperazine ring is essential for the enzymatic reaction.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRHPSHSPYRGGCEVRPKRRGLMLAHSSSESPPESLPDAWTVLKTRTAVRNYAKEPVDDALIEQLLEAMLAAPTASNRQAWSFMVVRRPAAVRRLRAFSPGVLGTPAFFVVACVDRSLTDNLSPKLSQKIYDTSKLCVAMAVENLLLAAHAAGLGGCPVGSFRSDIVTSMLGIPEHIEPMLVVPIGRPATALVPSQRRAKNEVVNYESWGNRAAAPTA
The following text describes a protein:
Function:
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3.
Subcellular Localization:
Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.
Domain:
The DOCKER domain mediates GEF activity.
Sequence:
MAERRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNLNIVGNISHHTTVPLTEAVDPVDLEDYLVTHPLSGDSGPLRDLVEFPPDDIEVVYSPRDCRTLVSAVPEESEMDPHVRDCIRSYTEDWAVVVRKYHKLGTGFNPNTLDKQKERQKGLPRQVFESDEAPDGSSYQDEQDDLKRRSMSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDHQNDDQRKSNRHKELFALHPSPDEEEPIERLSVPDVPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENFYFDLNSEQMKGLLRPHVPPAAITTLARSAIFSITYPSQDVFLVIKLEKVLQQGDIGECAEPYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDSTEVEISTGERKGSWSERRNSSLVGRRSLERTTSGDDACNLTSFRPATLTVANFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLYPDSRVRPTREILEFPARDVYVPNTTYRNLLYIYPQSLNFANRQGSARNITVKVQFMYGEDPSNAMPVIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEVVAVSSIHTQDPYLDKFFALVNALDEHMFPVRIGDMRIMENNLESELKSSISALNSSQLEPVVRFLHLLLDKLILLVVRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRNNLLASYIYYVFRLPNTYPNSPSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGPKAAPWGSNPSPSAESTQAMDRSCNRMSSHTETSSFLQTLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLDAPRESRFPERFMDDIAALVSTIAGDVVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRGFVFSLIKSCYKQVSAKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSLLTPPASPSPSVSSATSQSSGFSTSVQDQKIANMFELSLPFRQQHYLAGLVLTELALILDPDAEGLFGLHKKVINMVHNLLSTHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTESHNQRGRPICIAPDDYDSESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTFSAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLERSPSGSAFGSQENLRWRKDMTHWRQNSEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIIVQTVSVTESKESILGGVLKVLLQSMACNQSAVYLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRHCSSSISTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGCVTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKVLIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGDLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVLEVIKDSNPVDKCKLDPNKAYIQITYVEPFFDTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEVAQVFLSEIPGDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHRDSFSRMSLRKMEL
The following text describes a protein:
Function:
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Sequence:
MDLEVSASDMNKKIISASILSADFSRLGEEVKSVIQAGADNIHFDVMDHHFVPNLSFGAVVCKALRDAKITAPIDVHLMVKNPNEFIKPFAEAGANLITFHPETVKDVEDTIARIKKAGMQVGMAFNPEKSLSLFTSFLTKIDLVLLMSVNPGFAGQSFMAESLKKIAATRQLLDTLQSKAFLGIDGGIKINNIADVSRAGADFFVVGSGLFHSSNYEEKLKEMRHAINDR
The following text describes a protein:
Function:
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MDIVSLAWAALMVVFTFSLSLVVWGRSGL
The following text describes a protein:
Function:
This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Sequence:
MNKLANGPNYKVKPRRRREGKTNYYKRYVYVISKQTRFIVRITNKYVIVQIAKIDPKGDIMIASAHSAELAKKFGWKGDENNTPAAYLTGYLAGLRAIKRGVTECVADIGLHVPSKGNRVFYVIKGAIDAGLKIPIGDISIENDRIKGEHIAKYAEKLKSENSDLYSKLFSRYLQRGLNPENLPSHFEEILNKIKSSGG
The following text describes a protein:
Function:
May suppress DAO (D-amino acid oxidase) and SOD1 activity and promote their degradation. Has conversely also been suggested to function as a DAO activator. May stimulate the degradation of DDO (D-aspartate oxidase). May play a role in mitochondrial fission.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus. Mitochondrion. Note=May transiently pass through the Golgi apparatus.
Sequence:
MLEKLMGADSLQLFRSRYTLGKIYFIGFQRSILLSKSENSLNSIAKETEEGRETVTRKEGWKRRHEDGYLEMAQRHLQRSLCPWVSYLPQPYAELEEVSSHVGKVFMARNYEFLAYEASKDRRQPLERMWTCNYNQQKDQSCNHKEITSTKAE
The following text describes a protein:
Function:
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with sfc3 in DNA binding. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.
Subcellular Localization:
Nucleus.
Sequence:
MGPKSKEYENPSSYKNDEDNDDDGDFVLENVMSEEDIEIETPSRNRKRVSTTRRTPSKPIRSQPLTPSSSKGAGNEPKSQNSSTTRGSAKKQSSKGLEEKLINSYGTHVESLNKGRRLIEIWKYYETAPGQSSFEGQTSSDSKLQTLLNLDGQQLLSYSENPFYLFEVKNLSISFHFESPQQVEPCQPVNPFKENPQKSGFVVNTGIPLSSVSWLPTNKETQFLAVGGMLKFSETTESVFMRTSGRNQIQLWKLENKTNFKSEFILYHDWGSVLQLEWCPTISVEDSILGFLAVVCSDGKLRVLRVPRSPVKFHVFVEQADFTFGFNDSLISCCTWVSPEHGDIHQILVGCSNGYLALWDILSSQECPLFYIPYHDSYIHNVVQCLDDFPWLFLTTAFDCYTRIFDIRDPIIDNRPLSHKRDICYTITWNNMLQSIISCSESQSVVIESLRGTSTQLLDERNGSIISLSNSKFHPFVACAASDGIVTIVNPFRLLGFSHKQKANVHRIFQLEYSEKQDSYRMLDGFRPRLPKAKKLDMYIYPWQIQVNKVEWNGNKGYAGWLASGMACGILRVEDLSAVERR
The following text describes a protein:
Function:
Antimicrobial peptide with strong activity against the fungi C.albicans (MIC=6 uM) and B.cinerea (MIC=10 uM), and weaker activity against the Gram-negative bacterium E.coli (MIC=97 uM) and Gram-positive bacterium S.aureus (MIC=97 uM). Shows cytolytic activity against insect cell lines. Has potent hemolytic activity against ovine erythrocytes (80% at 50 uM), but has no hemolytic activity against human erythrocytes. In vivo, peptide injection in the vicinity of the head and thorax of lepidopteran larvae induces feeding disorder that lasts one or two days before recovering.
Subcellular Localization:
Secreted. Target cell membrane. Note=Has an amphipathic alpha-helical conformation.
Sequence:
MKQTIVIVLLAAVAMMACLQMVAAEPLPEAAPAPSPLAEAEALASPIAEALANPEALASPEAGRILSFIKGLAEHLGKK
The following text describes a protein:
Function:
Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Sequence:
MTVATPNQAVNQAFVLHPGGSFHYEQRAVPTLGSDRDVLVRVVATGLCGSDVHYWQHGRIGRYVVESPIILGHESSGIVVECGSKSGFAVGDRVALEPGVACNTCSHCRAGRYNLCREMRFAATPPYDGTLATYYLVPAECCYKLPPHISLRDGTLIEPLSVAVHSCRLAGDMQGKAVVVFGAGPVGLLCVAVARAFGASTVLAVDVVPSRLGSALKYGATHTYQMTPDSSEQNAEEILNKVELETGADVVLDATGAEPCLNCGIHILASGGTFVQVGLGKPNPSLPVCQICDKEIVFKGSFRYGPGDYQTAIELLHSRRIRLDGLVTHEFPFTQAEDAFQNVVSRAGIKSVIYGPGVDEHVAKATLT
The following text describes a protein:
Function:
Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MDLQASHSSTFILRELSFSVPGRTLLQPLSLTFPQGKVCGLIGHNGSGKSTLLKMLGRHQPPSSGQVVLNDMPLAQWDSKAFAREVAYLPQQLPAAEGMTVRELVAIGRYPWHGALGRFRQEDRQQVEEAIALVDLKPLANRLVDSLSGGERQRAWLAMMVAQNSRCLLLDEPTSALDIAHQVEVLGLIQRLSHERGLTVIAVLHDINMAARYCDHLVALRGGEMIAQGPADSLMQSAVLEQIYGIPMGILPHPAGGAPVSFVY
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MLYLEDYLELIEQLPNEFKSRFAKIREMDLQVQNDIDSLDTKVKDFFQNGRKAKSERKQSDYLDINGTYLNTIEVADEKIVIVRELQELLQRYTKRLVHELEKFKIELEADNPGITDQLEKHSFEFDHCCSPHTNSTIADMRFHQVSTAGQKRKRDTESTISKYNGILGISSKNSPKAAAFQALSTTKQMQQGMKLGIKASLLIQSSQELAEDGSVASKSHECFQVLNKESTKQLAKRKVQQKYVSSVDNGYNSAITSTPLAVDSTHNTEVNDEVSERPTTLEISEYVVDPDEPRYCICNQISYGEMVGCDNDDCPIEWFHYACVGISEPPKGKWYCPQCTVSMKRRSARSGHK
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKLKLIKELLENKKAEDIVILDVSKLTNLADYFVIATANSTTHARALADYLEEELEKRGIEIDHIEGKDYGHWILIDLIDTIVHIFTPETREYYGLEWIWADAKKMEV
The following text describes a protein:
Function:
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Sequence:
MYAAAKKASGPTLLLASLLATLLLAGLCPLTLVGSAPAPPIGSGEETDDVAAEDFGPAVLNPVALAKLIGREAASLQNKLCENHGVCDNSMEMLAENNLQLPKITTKDRCFSSGFQKNKCLNKIHHDLLIFEIYLLHVKETFRSERSTLESIEYKTNVLTGAIKRMMKRSKTESDDKETNTQITQVRKSENLWIQKVTNRLILQAFIDCIQKTARAVRYIGTFHGGKKI
The following text describes a protein:
Function:
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
Subcellular Localization:
Nucleus.
Sequence:
MAARRGRRDGVAPSPSGGPGPDPGGGVRGSSRGSRSQAPYGTVGSVSGGEQVLLHEEGEDSGFVSLSRLGPCLRDKDLEMEELILQDETLLGTMQSYMDASLISLIEDFGSLGESRLSLEDQNEVSLLTALTEILDNADSENLSPFDSIPDSELLVSPREGSSLHKLLTLSRTPPECDLITPVDTLGPSTGSSRVSGVEMSLSDPPWDFSPPSFLETSSPKLPSWRSSRSRARRGQSPPPQQRSDGEEEEEVANFGGQMLAGELDNSVSNIPDFPMHLACPKEEEKTSASEMAVQAAGDESISSLSELVRAMHPYCLPNLTHLTALEDELQEQPDDLTLPEDCVVLEIVGQAATAGNDLEIPVVVRQIPTRPQPVLLDDSLEASPALKLLMPTLESETEAAVPKEDLCPEKERLSVDSQEKLESVCLLKPREVMEPMMPKETHNTPANTMLSSQRARKGRKKKSKEQPASCAEGYTRRLRSSSRGQPTMATEVTSQARNVPQEEPQKEVGPPRSRGKPRAWARAWAAALEKPSSGNLESSAGQASCAKEDPLDRYSNLVDSIQANPVPTHVSARANRMPLDAVETDPTEVHPVLADPVPVDPALVDLASANPELVVSLPADPVLIDPVLADSAEIDPTVVVPISDDLPPGDPVPANSAPVDSVPSDLAPVDPVLVKSRPSDPRRGAMSSVQGNPAPRLLLESESLDPLKAVIPEVQEVGGPVKVESSTTTQEARPRPLSLSEYRRRRQQRQAEAEERSPQPPAGKWPSLPETPTGLADIPCLVIPPAPAKKTTLQRSPEVPSEACFVPVGPSPASSSPEPPVSKSVASTTIEQVPSQELPLPARPLPPVQPMPPAMPTALPFPPGGLGLTPVLPLPTSGQGIPSLPPPPLQPPSLPMSMRPVPPDPYTHYAPVPPWPCYPPVSPSGYPCLPPPPTVPLVSGTPGTYAVPPTCNVPWVPPPAPVPPYSSSCAYGPLGWGPGLQHPPFWPTLPPPPLPLASVGRAAPPPKVEPSGSPAGPSESVLPGSMAPPLCLGSAGQGAPPIEPTKVEVKSMPASPHMKHRMSSPVQSPQIKAPPCLSAESVAVEEPASERLKPETQEARPREKPLSSVAKAVSTPTPKQSTISKLPAVHPARLRKLSFLPTPRTQGPEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKECPPPAPADSLAVGNSGSVDTPQEKRPLDRLQAPELANVAGLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGVTEAKHPAATRLQEGVHGPSPVHVGSGDHDYCVRSRTPPRKTPALVIPEVGSRWNVKRHQDITIKPVLSLGPVTPLPPRTAASQEPLDHRTSSEQADPPAPCLAPSTLLSPEASPCRNDMNSRTPPEPSAKQRSVRCYRKACRSASPPSRGWQGCRGRSSRSVSSGSNRTSEASSSSSSSSSSSSRSRSRSRSLSPPHKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSSSSSRSRSRSPSPRRRSDRRRRYSSYRSHDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR
The following text describes a protein:
Function:
Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35-P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWEAIISFFLTSVLSVFAKKTEFLDRPDSRKSHGRAVPPVGGVSIFLTLLIFERDNPFFLFSIPLFLLGLLDDLFDLSYRIKLAVTALVAVWFSTAVTIEVSIFGARIHPVFFVIWFVGMVNAFNVVDGLDGLLSGISLFSSLMIGERSLAFSIIGFLPWNLPDAKVFLGNSGSFLLGAYLSTASVVFFEGDLGYATLFLGFPFYEIVFSFVRRLVVKKNPFSPDEKHTHHVFSRKIGKWKTLLILVSFSLMFNLLGLSQKFYFIFLYVVLCCVLLFTYCVLQRGNGNLKL
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIPLEAYLILAGLIFSMGLINLLINRNLIIVFVSLEVMLAGVNLALVALSHYMNDIRGQVLAIFTIAVAAGSVAVGLSLLIAHFNLKKSVDTEEIRELKEE
The following text describes a protein:
Function:
Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane. Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse.
Subcellular Localization:
Postsynaptic density membrane; Multi-pass membrane protein.
Sequence:
MLLVTLPAGHPGERAALSPNGFKMSFCYCFSCKNYKLHLSFQEMSLPILASSVVSLYFLELTDVFKPVHSGFNCYDKSLSMPYIEPTQEAVPFLMLLSLVFAGPSITIMVGEGILYCCLSKRRNGIGTEANINAGGCNFNSFLRRAVRFVGVHVFGLCSTALVTDIIQLSTGYQAPYFLTVCKPNYTSLNVSCSENSYVVEDICSGADANIINAGRKSFPSQHATLAAFAAVYISMYFNSTLTDSSKLLKPLLVFAFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSEENVFQSNFHREPLRSLTDLSQDANRILPGKNGSSTDGIVSHRSESILNRNHRDSGSLTNIKRANADVEIITPRSPMGKENMVTFSNTLPRVNTPSLEDPARRNATIHASMDSARSKQLLSQWKNKNESRKLSLQVIETESGQSPPRAIEMRSSSEPSRVGVNGDHHGPSSQYLKIQPGSVPGCNNSGLSGGPRVSIQSRPGSSQLVHIPEETQENVNTSPKSSSARAKWLKAAEKSVACRSNSQPRIMQVIAMSKQQGVLQSSPKSSEGSTVTCTGAIRYKTLTDHEPSSIVRVEAHPENNRPVIQMPSEGEGSGSWKWKGPEKVTLRQTYELNDLNRDSESCDSLKDSYGSGDRKRSNIDNTEHHHHGITTIRVTPVEGSEIGSETLSISSSRDSTLRRKGNIILIPERGSSPENTRNIFYKGTSPTRAYKE