lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential protein. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. Required for the development of megagametophyte in female gametophyte (embryo sac) independently of cytokinin. Contributes to vascular bundle formation and secondary growth in a cytokinin-independent manner, probably by promoting the maintenance of mitotic activity and/or identity of procambial cells. Seems to influence and promote the cytokinin signaling pathway.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMVKVTKLVASRPIVVFCVLAFLVVVFECIWISNWRTTTENLVKEVASFTEDLRTSLVSEIENIGKFTYAKTNLSTIGLARVIDSYITNNDTGFTEIQTQIAPLLFVAYSTILQVSQVSYISRDGLMFSYIAESNTSVAVFANSSSNSSRGDYTWYTQTVDQLTGRLNGNSTKSQSLDVTHTDWFQAAQSNNYTTAFVGTSLGGEDNETLIQSVVSLYSKKGLVSLGFPVKTLTEVLNSLNLHGEELYMWTKDGTVLVREGSLNDSFFISNGSICFGRESNSLWSQCIPENCSSSGYEVEIKRLRYQAFCSVIEVSGVPLRYTLMFPNKGGATRIKHQAEKAKYQLIVVMIFLGFGWPVWFVWFMMQATRREMHMRATLINQMEATQQAERKSMNKSQAFANASHDIRGALAGMKGLIDICRDGVKPGSDVDTTLNQVNVCAKDLVALLNSVLDMSKIESGKMQLVEEDFNLSKLLEDVIDFYHPVAMKKGVDVVLDPHDGSVFKFSNVRGDSGRLKQILNNLVSNAVKFTVDGHIAVRAWAQRPGSNSSVVLASYPKGVSKFVKSMFCKNKEESSTYETEISNSIRNNANTMEFVFEVDDTGKGIPMEMRKSVFENYVQVRETAQGHQGTGLGLGIVQSLVRLMGGEIRITDKAMGEKGTCFQFNVLLTTLESPPVSDMKVRQEIEAGGDYVSTPNLGLTINTSLGGSMNIRNLSPRFNNCLSSSPKQEGSRVVLLLKNEERRRVTEKYIKNLGIKVTVVEKWEHLSYALERLFGFSPQSSMGRAECSLSCPSSRELPFIGMDGIDSRSQLPKRRSISFSAVVLLVIDAKTGPFFELCDIVKQFRRGLPHGISCKVVWLNESSTRVSERGDISCSRPLHGSRLMEVLKMLPEFGGTVLKEPPTELQRESLLRHSFVAERSPKHKVQEEGPSSMFNKKLGKRIMASTDSESETRVKSVRTGRKPIGNPEDEQETSKPSDDEFLRGKRVLVVDDNFISRKVATGKLKKMGVSEVEQCDSGKEALRLVTEGLTQREEQGSVDKLPFDYIFMDCQMPEMDGYEATREIRKVEKSYGVRTPIIAVSGHDPGSEEARETIQAGMDAFLDKSLNQLANVIREIESKRH
The following text describes a protein:
Function:
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup.
Subcellular Localization:
Cytoplasm. Note=In cleavage embryos.
Sequence:
MTSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINTQVITQ
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEENKSKVTLHGMWASSYSKRVEIALKLKGILYEYVEEDLSNKTESLVRLNPVHKKVPLLVHDGKPVAESQVILEYIDETWNNSPRLLPEDSYERAQVRFWVSYINQQVIEVMGKVLFQEGEAQEKAIEEARERFKVLEEGLKKHFPNKTIRENDDVGLLDIIIISTFGSHKVYHDVFGVGVIDQVNTPTLYNWIESLKELAVMKEAEVPSDRLVPFLQMYRQMHLQQAANA
The following text describes a protein:
Function:
May contribute to the regulation of cell proliferation.
Subcellular Localization:
Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MISRLTFRNINNIKIYNRFIKSTSLLNNSQTVNNYIPTGLNQQYSFNNNHNINNNNNNNNNNNKSFCTITKNKLLNVTKEMSVTSRKLTEKQKGDIEKFDNENLLGKGILRGAPDIFNGITVENTQQYPKDPIEFSKYLENSIKFWSDNNRRGVWLKIPQSHSNLISIAVEKGFEFHHCQLDYLLLTKWLPSPESNDPNKLPQYTSHFIGCGGVVINDKKEILLITEKQRPDKWKIPGGSLDSGEDICATAVREVFEETGVKTEFVSILGFRQLHNYAFNRGDIYYICALKPISEEINIDPHEIALCKWAPVEEFVLTQSTFPLQQAVSQLAHEYAFNGYKGFKASEVANSLKPGNSFVYHGSNLDFTDLKNKL
The following text describes a protein:
Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MESSSDAVGNGTASSTSAMPSPLQIALWNGNLQQIRECLRIGGQEALETRDARGNRALHLALKFAHRNATAIVKALLDAGARVRSRDTDGWKAIHHAVVSENEEILRLLVRRGEFLSIKEQAPALLQKKIDSICPRLAQIPDFYCEMLIDVSTWIPGVSRWLPSDTVKIWKAGQDIRFDVTLVGFEDGKWDRGDLSFLLQGAQGKFLCLDNEAETCTDLLKLDSELTEADLDQMVHFLMITSIVATDLDASKVAFEKKCAWFSSAPMRQNIGRWNGTRVVDMVGVEASLRYRKPHNPKHAPPKSANEQPVACDAVSMLTEAAAITDHYTDVVVEPKSNHIVSVELTKGEGLRWKFSTEKRDINFGVRFLQENNGDEWVEIVPLQRTQAHLNEETGSFEASSSGTLVFTWDNSYSVIRPKKLRFAICPAGEEDKDSTESENWDVQMRVKEEEMAFEDWFGVPVESLPVSLRAMRPRRCIMVHIQPACRKIAKSFPATVYMSDQFPLTALTDGFPVQFCFPLVPSVSATFRFERMELQTPEPCMFTVPSTYTMHAEDMLSPRTHQMMLQRVTAT
The following text describes a protein:
Function:
Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
Subcellular Localization:
Nucleus.
Domain:
The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.
Sequence:
MDNFPAVKKDRYSVLTGMEVPIPASLGLTPVTEDLPYIKFSEWKFKLFKVRSIEKPSSVETQPRNKENPPPEKSVLGNTSAVLEDASGAVLDKPAKVQAGLCSLLNASGKPTDDEKAREIARHQANLQQLCRICGFSFKADLHNRKHPVHGPVDGKTQALLRKKEKKATSWPELISKVFKIDVRGDLDTIHPTQFCHNCWSIIHRKFSNAPCEVYFPRNATMAWQPHTTACDLCHPTRQKLKRKRCQVNQQLSKKLKTGPAQAKKSRQAKSQARKSNGHQILMKKITNCSKIHLSTKYLAVDYPADFVRSISCQICKHILADPVETTCKHVFCRSCIFKCLKVIGSHCPSCRYPCFPTDLESPVKSFLNILNSLVVRCPAEECDEEVSLEKYNHHASSHKETKETHVHINKGGRPRQHLLSLTRRAQKHRLRELKLQVKAFADKEEGGDVKAVCLTLFLLALRARNEHRQADELEAIMQGRGSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQIFQPLHSLRTAEKVLLPGYHPFEWDPPLKNVSANTEVGIMDGLSGLPVSVDDYPVDTIAKRFRYDAALVSALMDMEEDILEGMKSQDLDDYLSGPFTVVIKESCDGMGDVSEKHGSGPAVPEKAVRFSFTVMNITLAYEQENVKIFEEAKPNSELCCKPLCLMLADESDHETLTAILSPLIAEREAMKDSELKLEMGGILRSFRFIFRGTGYDEKLVREVEGLEASGSVYICTLCDATRLEASQNLVLHSITRSHAENLERYEVWRSNPFHESVEELRDRVKGVSAKPFIETVPSIDALHCDIGNAAEFYKIFQLEIGEAYKNPNASKEERKRWQATLDKHLRKKMKLKPIMRMNGNFARKLMTKETVEAVCELVHCEERHEALRELMDLYLKMKPVWRSSCPAKECPESLCQYSFNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWASEGNESGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTSKYLQKFMNAHNALKSQGFTINPESSLEGSLVLEDSLEPQDSMEF
The following text describes a protein:
Function:
Required for the development of the one-cell zygote and endosperm in embryos. Required for micropylar pollen tube guidance, but has no effect on ovule development and gametophytic cell fate specification. May connect transcription factors and the Pol II machinery to regulate pollen tube attraction, via its interactions with AGAMOUS-like (AGL) transcription factors, MEE14/CCG and the Mediator complex.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MIKSVTLRSFHLPIEFNDTKFVSRPCFLARSFPVVRCSSTRDVPKLELFSRGKFDRILQDPPLIEKAESELSDYCSTLEGDDSYSCWRAYFELKDLEREKPKVEVENLILQTGGLKSLIGCLHGVASMEKDNKTKNGLHVGEESDREKGMNLHIHIPDGLPKSEQELEEEEKSKMPDSAFTRLLRSKGTIPAWFSHAPDHETD
The following text describes a protein:
Function:
Plays a role in tubular endoplasmic reticulum network formation and maintenance. Works in conjunction with the ER shaping proteins (reticulons RTN1 and RTN2, YOP1), and in antagonism to SEY1 to maintain the network in a dynamic equilibrium. May counterbalance SEY1-directed polygon formation by promoting polygon loss through ring closure.
Miscellaneous:
MISCELLANEOUS: Present with 3390 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to three-way ER tubule junctions. This localization is SEY1-dependent.
Sequence:
MFSALGKWVRGSRNDKDFVTKYTADLSQITSQIHQLDVALKKSQSILSQWQSNLTFYGIALTVLALSYTYWEYHGYRPYLVVTALLCIGSLILFKWALTKLYAFYNNNRLRKLAKLRAIHQKKLEKLKEETHYNATSSIIQRFSSGEDQNDDAMVLLDDELNAKYQELNNLKTELEKFKKESHVKGLKKEDSDAWFDKIISVLAGGNELDSTSSLSPFKKIICPQCHWKSNCYRLASKPIIFICPHCNHKIDEVKEREDAIEAKQPAQPSQSEKEKTK
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus.
Sequence:
MALNLDGKRKLAEEMQKRDYDDQIERNKLHLAEKNKFRNLERCMHNIRRERETADKILEVKQREAFSEKRLEKTEALARELDKIKRIELRDLKLRQSLRENCHELRELESKLRTAYVSKELATQLAEKNARKLEDKLRQQEEYRKLQESLVTIDEMNQVAAEEELKKKAQYRQELQDQMIINEKRRRYLYDEFLREKKMIDDIVQRIYAEDERERQEKMCKMQKTKEEMDAFKKAQQIWRNKEKEEIDKENQRIQEFITNKALEMQSREQKKNELEAIKAKLTENIAKQMYEVEMRRKEREEIMQELYEEEQKQAIEQRHKANLEKELRQRIEVRESLRDQMLQREEKLREEAAADAKYKEELLAKMAEDQRLEQLSNEKRRLKMLECRREIERMMEERRQRHAEEMQVLMKLKEQEEMEAEERRRIIEEERLRMLKEHAKNLIGYLPKGVLRPDDLTHL
The following text describes a protein:
Function:
Binds RNA.
Subcellular Localization:
Nucleus. Note=Distributed in the nucleus in a dot-like pattern.
Sequence:
MAEPTSDFETPIGWHASPELTPTLGPLSDTAPPRDSWMFWAMLPPPPPPLTSSLPAAGSKPSSESQPPMEAQSLPGAPPPFDAQILPGAQPPFDAQSPLDSQPQPSGQPWNFHASTSWYWRQSSDRFPRHQKSFNPAVKNSYYPRKYDAKFTDFSLPPSRKQKKKKRKEPVFHFFCDTCDRGFKNQEKYDKHMSEHTKCPELDCSFTAHEKIVQFHWRNMHAPGMKKIKLDTPEEIARWREERRKNYPTLANIERKKKLKLEKEKRGAVLTTTQYGKMKGMSRHSQMAKIRSPGKNHKWKNDNSRQRAVTGSGSHLCDLKLEGPPEANADPLGVLINSDSESDKEEKPQHSVIPKEVTPALCSLMSSYGSLSGSESEPEETPIKTEADVLAENQVLDSSAPKSPSQDVKATVRNFSEAKSENRKKSFEKTNPKRKKDYHNYQTLFEPRTHHPYLLEMLLAPDIRHERNVILQCVRYIIKKDFFGLDTNSAKSKDV
The following text describes a protein:
Function:
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAELAVRGVQAFRAPSRAGRGCRGQGEAGRTSFRREGVMASRPRVPASTGSVKADDPAPRPKPGRSTAAHGRRTRYRLKSHLPSYCDESLFGPPAQTPTWEPPWAEKKEGSRSQPLLWTPSTFSTCCAQAPHVTSAHPPLSSTELAPYQGKTDFWRRPESEEEVGDTDWRPQKDVGLMRKTKSACAGLGATDKGKSAHLASLCLPHRRPKTTASIKAKPPWKY
The following text describes a protein:
Function:
Promotes plant cell differentiation, organogenesis and somatic embryogenesis as well as cell proliferation.
Subcellular Localization:
Secreted.
Sequence:
MGKFTTIFIMALLLCSTLTYAARLTPTTTTALSRENSVKEIEGDKVEEESCNGIGEEECLIRRSLVLHTDYIYTQNHKP
The following text describes a protein:
Function:
Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues (By similarity).
Subcellular Localization:
Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane. Synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Mainly located in the lumen of the endoplasmic reticulum. Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2 (By similarity).
Sequence:
AECCGQKRSLSREALQKDLDDKLFGQHLAKKVILNAVSGFLSNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSDYVHLFVATLHFPHASNVTLYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDVVDEVSYQKAIFIFLSNAGAERITDVALDFWKSGKQREEIKLRDMEHALAVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEVDEDIISKVAEEMTFFPKEERVFSDKGC
The following text describes a protein:
Function:
Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MKTRDSQTSDVIIIGGGATGAGIARDCALRGLRVILVERHDIATGATGRNHGLLHSGARYAVTDAESARECISENQILKRIARHCVEPTDGLFITLPEDDLAFQATFIRACEAAGIRAEAIDPQQARIIEPSVNPALIGAVKVPDGTVDPFRLTAANMLDAREHGAIVLTAHEVTGLIREGATVCGVHVRNHLTGETQTLHAPVVVNAAGIWGQRIAEYADLSIRMFPAKGSLLIMDHRINQHVINRCRKPSDADILVPGDTISLIGTTSTHIDYNEIDSNRVTADEVDILLREGEKLAPVMAKTRILRAYSGVRPLVASDDDPSGRNVSRGIVLFDHAERDGLDGFITITGGKLMTYRLMAEWATDAVCRKLGNTRPCITADTPLPGSKESTEHTLKRIISLPAPLRGSAVYRHGDRTPGWLSEGRQHRSLVCECEAVTAGEVQYAVENLTVNSLLDLRRRTRVGMGTCQGELCACRAAGLLQRFNVTTAAQSITQLSEFLNERWKGVQPVAWGDALRESEFTRWVYQGLCGLEKEHQDEI
The following text describes a protein:
Function:
G1/S-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 phosphorylates LCB4, which is required for its ubiquitination and degradation. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit.
Miscellaneous:
MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the incipient bud site.
Sequence:
MCEYSKALHILLKSPVTDDIIKFLTDTTLRVVPSSNYPTPPGSPGEKHLTRLPSLMTFITRLVRYTNVYTPTLLTAACYLNKLKRILPRDATGLPSTIHRIFLACLILSAKFHNDSSPLNKHWARYTDGLFTLEDINLMERQLLQLLNWDLRVNTEDLILDLQPLLEPIKQDLARSSDQRKRINMMMSMNRRTCAGTSPIRSNNRFKLYEKQRNVSIASDLSSATLVDSCNDLRRLKDVTNIANNTVANTNYVRTVEKWNDNVNRQSWDLEQIMSQHGF
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTRAMINKYKSHRIFFSMSHYLNCAMDGANESVVSEFVFLGLSNSWEIQLLLFLIFSVFYMASLMGNLLIMFSVRVDLTLHSPMYFQLANLSFLDVGICSIAAPKMVYDLFRKHKTISFGGCIPSLFMLLGVQKRCCSLPWPLTDMLPYVSLSLVLGLIHSVAQLAFVVDLPFCGPNVLDSFYCDLPQLIKLACTETNRLEFMVTANSGLISVGSFFILIISYIIILTIVWKHSSGGLSKPLSTLSAHVTVVVLFFGPLIFFYTWPFLSSHLDKFLAIFDAVLTSFLNPVIYTFRNKEMKVAMKKLCHQLVNYRKIL
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MLSGDDGVDLQCCVTVEQLNSSGQATRRKLIRKAAVILGRNEFQEILLRVHDGKLAQSYRLKEFQLFTKFVRDGKCTVKLLPENTQVLLSNCPPDRLSLFLKTLSIKHQAWRSCKPLSEREKLKAALPRSFEAISPLQQKDIQKANELRSKASGGPADCTNRAGGKQQVKRGRGDTSSSPEKTNPNKKPTLTLPSRRLSKEQTAVLSAVLRGKNVFFTGSAGTGKSFLLKRIMGSLPPKSTFVTASTGVAACHIGGTTLHNFAGIGSGSAPLEQCIELAQRPSVLQHWTSCRHLIIDEISMVEAQFFDKLEAVARSVKRSTQPFGGIQLIVCGDFLQLPPVSKGKEKASFCFQARCWRKVIQVNMELTEVRRQTDQNFISLLQAVRLGRVTEEISMKLMTSSYHRIERDGVLATRLCTHKDDVELTNEDKLQQLPGSVRLFEAVDSDPELVKNIDAHSPVSRLIQLKVGAQVMLTKNLDVARGLVNGARGVVEAFESEKKGLPRVRFLCGVTEVLRPERWVFKSASGVHLSRTQLPLKLAWAISIHKSQGMTLDCVEISLARVFESGQAYVALSRARSLEGLRVMDFNPHVVRADPDVLLFYKKLRKERLLVQQNHNKNHWEHLKKMEWDF
The following text describes a protein:
Function:
Probably involved in maintaining Golgi structure.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MEKFGMSFGGGPSKKELLETIEVQKKQLVKYQTRFKDVVRAYQSLLKEKEALEASLKVLTISQEVDLSRVDNLSFGEASGSRALPSDLGDDRCSLHSEDSLDTAASAETATSVTSNSTKGDQIEDDQSCAVDGATAGAVVHTSPQQSEEASGSESGVSTSSSGCSEPTPQVADTDRRVIQLKTQLSTLTSSLATVTQEKSRMEASFQADKRKMKQELEELQARLEEDKKQHQAELQNLQEQFAESKARVITQQHEREQEQGDHALMLRELQKLLQEERGLRQDAELKLEDARATLAEAMQAADRGLDYESQLKEIIQERDELKKSLKAAAVENSKPDPRVEELQQENADLKAHFNQQLQQEIRKVAQADELLREQAKMEEIRVASLEERVSELSELLGACEKARQKDQQNTQRLRERILQLDTENKTLAMAAVNRTTSSDLNMDDMNLNVDALKDKLEKVKKLLLLAAQRSQDQSLDIEKLLEGGEKDHEVSESEKASALHYQQELRQIKEEFERYKMRAQGVLKNKNTKDGNQAKELEEARDQLAELKEKYINLRIQSDEAEVKHKRDLEERQQGLAALQQTHKQEVEKLEAQHRENFMRLEEELHKQRDRTMALLAEKDLELERLRASAVMGFGSHQRHIINSSAALEGGDLDEVDPEQEESDIIAQALKLAGPNEPTLLLYAEQLARKEVEVAALRKQKHRLEEDLHQLQGKLIANGERHEEELVELRGQLDKRIRDKGRDGANLEYLKNVIYKFLTLQDTRGRQQTLTAILTILHFSPQEKQVVLKQQQHSWWTAGMR
The following text describes a protein:
Function:
May play a role in the regulation of membrane traffic through the trans-Golgi network.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MSGVPSSAGNVFAGLNNLIYEVGLDQPGTLLEEMIAQACDPSFGQPNLSLNLEICDMVNKTQKTYPRDCAFAILKHVNRGNNTAAYLSLMLLDSCVKNCGYPFHLVIGSKEFLNELVRRFPEKPTNITATQHRILELMQLWNATLCVNSRYKEDFKHINDMYRLLMYKGYRFPELREDAVKSFNGNNNLKTEDELEEEDRKAHGVKLEELIRKGTPAALAQANELMKVMTGYDVSKKPDYKKEVNQEIERIESRIILLNDMLNQRRPGESLAADSTIEELYGTAKSAQTKLQSFIELNDDEDRLARLLELNDLINIVLQKYSDVKSGKAIRHNDFDRKQAASEKSSNAPDSVGPINLIDFDDLSFPAAPASNFMAVPQTMSNLTNSKQSSISPGIMDGISDLQIGALPTFASMSAEVPFQQSRSLGNPPFFPPSKYDGGATLLQIQQGGAAASKSLQDTTNSLDPFSIFGNTDAMNKPLLGAPMSAGGISTTQPAQLGYQGTFSSFQSKNTDLLSMPTDFSMGLGSQMGQRSNTTSTQNATFASPTKEVMMYDKNGLQIKLLICSSHGPRTVDAKAVFINVTPVLFTGLSLQIAVPKSMTLTMDKPTGTTLAPLNQAQITQPFSISNPTMESVRLRFKIQYSINGATVNEMGEYALQ
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MIKKISGRIVTHEKDFLGTVEWDSKTGLILTVLEQKESIPILNSQHQENEIQFNSLETVIFPGFGDIHIHAREDESGKHTYKEDFVSASAAAVNGGVIHVADMPNNPIPPIDENSYSKKRKLADRSNIHITLYAGIGPDTKPLKKSVPYKVFMGPSIGELFFHNNQTLEDTISSYVGENVSFHCEDPEILEKHQNETFHEDRRPAEAETTATDFALYLIEKYNLRGKLCHYSTGEGLNKIKFAKQKGVKVTCEVTPTHLFFDRSMLTPENRHWFQMNPPLRSKEDRERMLEGVKQGWIDYLATDHAPHSIEEKRKGTSGISQLDTYSLFVTWLVLKAGVELKTVARICAKNPGDFVNEYLPEKFGKGFGRIEPGYSANFTVLNLKKPKKFLKEEIKSKSGWSPFENFEFPGSIEAVFFLGKQMK
The following text describes a protein:
Function:
May be a peptide transporter or a protein that facilitates peptide internalization.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTSRFMLIFAAISGFIFVALGAFGAHVLSKTMGAVEMGWIQTGLEYQAFHTLAILGLAVAMQRRISIWFYWSSVFLALGTVLFSGSLYCLALSHLRLWAFVTPVGGVSFLAGWALMLVGAIRLKRKGVSHE
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MATETNKITLLTADEEEFVVDEAIAMEFGTVKTYYEDNPDSCDEAIPLPNVTSKYLAKVIEYYKWHYEEEEDEEAKAFDEALFNTLDNEGMKQMIMAANYLDAKDLLEMLTQAVADRIKNKSVEYVRKVFGIENDYTPEEEAELRKQNEWAFEDLDPDDN
The following text describes a protein:
Function:
In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Subcellular Localization:
Nucleus.
Sequence:
MVNATKGVFISCDIPMAQYIVNMNASLPASDKFIIHILDSTHMFVQPHVEQMIRSQIAKFREDNTYVKPS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
Sequence:
MALIDISRSVSPATAVWPGDQEVQWTWTARRNEDESSVNLGSLRLSTHTGTHVDAPLHVKRQGQATDDLPLDSFVGPARVVDVNANAPSVRPEHIGQLDGASAERVLFKTSSGVSPDDEWPDAVVPIQPDTIHALADAGVSLVGTDAPSVDPLDSTDLPAHHALLDTGIVNLEGLVLTNVPPGRYELIALPLKIVGGDAAPVRAVLRDAPDP
The following text describes a protein:
Function:
Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond. Possesses activity toward the single-stranded DNA, double-stranded DNA and RNA. May be involved in genomic DNA degradation during programmed cell death.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MGNALTFLYGKCCKPTTTDDSLGPHGVSAATVGVSALAHDLFNFEITSQVPEGLGRYVQSSRKAQANWYRKILEAWKQAKPPPQTAEEASRLVTDILKRNQKADVEGLLSFYGLPLSHTLVEVTVEAPVSLPEGILFEFQTLPVDPKAVADGDTITVYVSTSEPVVSSSVPREVNLAAVQRAKAREKRNYPKADELHQKIIDSGYRVLNIENEEVLARKFRIRLRGIDAPESQMPFGKEAQEGLLKIVGRKSLKVLVYGEDQYGRCVGDLYCNGIFVQEAMLKKGLAWHYLAYDKRPVLAKWEKEARQKRIGLWASSNPEKPWDWRKNNRRE
The following text describes a protein:
Function:
May play a role in transmitting a signal which both protects non-diapause eggs from cold injury and terminates diapause in diapause eggs.
Miscellaneous:
MISCELLANEOUS: 'Samui' means 'cold' in Japanese.
Sequence:
MESPVVLDKPPEYHGDRGFPFEEEEGSGAWSELAARHPDIAARLRQRPATWARKRRPSSNDATDDFGDNFSGFDRFPFDDIPPEFREHFPSHWNRRFSSRDEQPQQQTPASPTQPQQQTTATQTEQTPTHSEHEQQTQIPQYGLRNTVDLGQKSPADPSLVDADDRTHRSMSAPPDTPNQTKMSVHNHQEQTHQPHGETQSNVRHIPIFVEGRDKPVINKSVDHGTHFGEAKPQYVPPPPPPHVDRDQYFADDVNFHPPPNFSRSFGTPFNKTYRQGPQPFVQQKAYPQTAFARGASPQRSQSPKPTDEHFVKVPVHHETPKAEPPSRAQKSPQQHQPPPPKSPQQHQPPPPKSPQQQPPPQREQTPPQPKTQQPSSNDPITQILSIQTDVLNLMTDVENFTGTKKDKRYLFLDEMLTRNLIKLDNIETDGKENIRQARKEAIKCIQKCIAVLEAKADSSNQQRKAQPEQETQVQDECQSHDVDMKENTQNDQTTEIPAQPIVENGEVEMDEATKEKPAEPQTAAAVPPQTDNTEEANVEKQAVESAVAVEKDEKQEVVKVEAQEKSEEVKPEDANASGTVNPAETQPPAADTRPEDNKSTGGDAEKKEDKKSTPKKVTKTVKKRDKSKDKKDAPKDSNKEDKIEANSVLNPEPMPVDEKGDKTDSQVMDVDGAASQ
The following text describes a protein:
Function:
Plays a role in the development of the nervous system such as in neurite outgrowth and elongation. Involved in motor axon growth and guidance. Required for correct interactions of motor axons with the horizontal myoseptum.
Miscellaneous:
MISCELLANEOUS: Overexpression partially rescues the motor axon defects upon Smn-depleted.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRATLRILCALTFLVSCSRGARVVSGQTVCQGNPEHPCYKIAYFKDVSSRVAFWEALQACEMDGGSLLSIENTAEQKHIEHLLRELSVSSSTGPASITDGDFWIGLTREEGDNAQEPGAFASCPNLYRWTDGSVSLFRNWYADEPSCGGEACVVMYHQPTALAGPGGPYLYQWNDDRCNMKHNFICKYEPESHLVKVQSDRPGGHDVDLSTEDKEDRRTPPTDEDESPRLIIAGPSSMLLIYVIIPTIPLLLLILVASGTCCFQMLSKSKPRTKTSVNQSTLWISKTPKIDSGMEV
The following text describes a protein:
Function:
Component of the auxin signaling transduction pathway that regulates cell proliferation and differentiation during flowers stigmas and styles development. Involved in the regulation of auxin-related genes.
Subcellular Localization:
Nucleus. Note=Inside the nucleus, confined to the interchromatic region.
Sequence:
MGSDKKTPEEKRKHKRSSPSSPLDEVKSKRQNIKGDEERRKEKKDKSKKEKHKSHSSEEKKSGEKHKTKSHKHKDKSKNKFEELSKDDYFSKNNEFATWLKDKKNLFFSDLSSETARDLFSDFVIQWNKGKLDSQYYEGIATGPRSSHAWNIKK