lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor. Involved in the control of tapetum development. Required for male fertility and pollen differentiation, especially during callose deposition.
Subcellular Localization:
Nucleus.
Sequence:
MGGGSRFQEPVRMSRRKQVTKEKEEDENFKSPNLEAERRRREKLHCRLMALRSHVPIVTNMTKASIVEDAITYIGELQNNVKNLLETFHEMEEAPPEIDEEQTDPMIKPEVETSDLNEEMKKLGIEENVQLCKIGERKFWLKIITEKRDGIFTKFMEVMRFLGFEIIDISLTTSNGAILISASVQTQELCDVEQTKDFLLEVMRSNP
The following text describes a protein:
Function:
Promotes the exosome-mediated degradation of mRNAs containing a DSR (determinant of selective removal) signal sequence from mitotic cells.
Subcellular Localization:
Nucleus. Note=Localizes to distinct foci in the nucleus in mitotic cells, which disassemble during meiosis, although the protein is still present.
Sequence:
MSRSINLDELRKKALESKKKNEEDESNDSDKEDGEISEDDPVIDQSNSVPPMKVPTFPEQIPQLPPFDRFPGTNANFFPFGAPFMLPPALMFGPNTVPFFPQTASSNKTFSKRKRSSENSFNNRNKAKSSETSDSSNTSQSFKENRALKDTATSRPLALSSDTSYQKSEKAKSEKSPFLSTSKNSDANYSKTTNQKEAEKAVSQLFEVGVRFNDFIAEGIEPSVVHTLFLKLGLDSSSASSQGSLTLSADKAARSAKLRKIDSNLSDTHILPGDNGTPTVLPERKNLISLPLLKQDDWLSSSKPFGSSTPNVVIEFDSDDDGDDFSNSKIEQSNLEKPPSNSENGLTMSRSDYLALLRNKEEEIRRMTKLILRLESNKKPYRSPTSAADMKLPSVPVAAVDNKSKTHLDTFEKVVDLSSKADFVEAGPSISSSGASSSAATTNSDTTEQILEAPWLRKTEQIAVVHEEHPAQIKKSEIDILNNLIEKEEGELTKYQTLVKSKTEILTQLYTRKKQLLEQQGKGNVACLPKESDLSMDSITEVSAQADENSSQILSSKTSNAPNGTTETDFEDKVPLVDYISPFYRFKSYRFNQQFVERVPLKYRSLTYSNKIEPMKVFCKYETTGGVCNDDHCEASHFRDIKMTDDEIIQDLSRYIEGNDEIEKESYKSGLDIVMKNTDENTDFVDVATRIVEYHNLWKSERMTIPVAKVSI
The following text describes a protein:
Function:
Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.
Sequence:
MLWIYISNESHVLQWDLIQLDERLTIMEESVLILPIDIRRLCSREILVVKVQRRHRPVKEVTWENESKLQAKYPHLFEPSAEEEEQNKPKEKSSHESTNMSKITNVRQDSSCQGRNVVIKDAAIELGKELISRNIDLVYGGGSIGLMDLVSQAVHYGGRHVIGVIPKILMPRELTGETVGEVKEVADMHQRKAKMARHSDAFIALPGGYGTHDELLEVISWAQLGIHDKLVGLLNVDGYYNSLLSFIDKAVEEGFISPNACQIIVSVPTSTVLVKKLEEYVPCHERIASNLKWETELI
The following text describes a protein:
Function:
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. The MinCD complex plays an important role in asymmetric septum formation during sporulation of B.subtilis cells.
Sequence:
MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQYTDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREEAEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNNQAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPDLTRLEGGM
The following text describes a protein:
Function:
Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2. Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nuclear or cytoplasmic localization of IRS1 correlates with the transition from proliferation to chondrogenic differentiation.
Sequence:
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MYISHRAPAKMAAKFRRLLPLVALPGSASLGAVYAAEAVKKEETDCGCGKKKKTVGISELPIYDQPTDLEQYTYIEEDVGFLRQHVSKVRQAVWTGLDKMEGTRVYVVDKYRIAEKKTTDGLEYVQSEEGFFPRLGVITLSGLTGLVLGARGGLIKKAVYSTTLAGAAAFLCYPNLYTSVTNYSVSCY
The following text describes a protein:
Function:
Involved in the interconversion between alpha- and beta-L-fucoses.
Sequence:
MVILKGIPSVLTPELLYVLAQMGHGDELVLADANFPTSSVCKCGPVEIRADGVRIPELLKAILKLFPLDTYDESAAVMDLVPSDLLKGLKVPIWDQYSELLKQAGSDGNMKPVERFAFYERAKKAFAVVATGETALYGNLIIKKGVIPPEEQC
The following text describes a protein:
Function:
Probable polyketide synthase.
Sequence:
MSNIKKNPITVFIFCGHGAQWNGQGLQLYNNEPTYKNLMDMLDKKFYEYFGYSILKKLRSIPDNDLISIQDPILAQPATCMLQVSLFELYKEWGISPSFIIGHSLGEISAAYCSGMIDIDTFCYLVYNRSVAQSKTNGSGKMLSTLISEEDYKDNYLSKFPNIEVACYNSPSSVVLAGNEENLKEISKDLKKRNIHSAFLGSLSSFHTSSQLKIKDQILSLSFKSKEPLIPIFSTVTTQLFTKETPYTPQYLFDNIHKPVKYSQTIINLYKHIENNDLGNEIAFVELAPHSTLAFYLKQMMPSTCDQINSNYFNTNLISIHSPLNKKKPNDNLGFMETISKLYCDSNYIINFKYQFKNKSLKPLSGFKNQLLPKYQFEVKSPLKSYTTLIDIKKQPFQFLKGHQVLETKLDIHDIIKNHCNLAKLNKTELYSNIKLKTGLNYSGAFQGVSEFYIGEKCSMAVIPLGLSQSIDSKSFFNTALLDTCLHGFIGLIEETSNIVFDSVENMIYYASNIPSAERKSQHENLYVYTLIKSRKGNNFYGSIKVLLSDGTILWDMKNACCASLSLVKDVLTLEYPSDLVFSRYLQSKDSPFETPNSFNNLYEEFEIKDIIDLEYPNCSLTKKVLDSIYQLINESDSYEIDIELTWTDISPSIIEEAKEKLSNFKDKRVEIIFNHLDLNEELIGKQSIKPSYYDMVIMSNVLNIVSDVKFSLNEIYKVLAPKGYLLFIELPYKSIIFDCIFGVFDPWWQNFKDHNIRKDRACLDQKTWNKVLGEFDATTTNYLASSVVGANTYYYEFPLLNTFSIDFDKVSINNMNLHKIITPLINPKINNQREYMVRNNIVYYERFKKESLSSLKKDFKSNSYNNINNDEVFLHLDFNLEYILRSKKTQLKPNEIEVKVESFGINYKDFLVHNGLLPSEMMNQFGNSNDPELGCEFSGVIKKIGENVTKYKIGDNVFGAYFNSSASHIIVDENYICHKPSNITHTQAASLPIVYGTSYHSIYNIGNLQQDETILIHSASGGIGLSSLNILKWKDHKGLIFVTVGSTEKEKYLKEKFGSFISGIYSSRNKDFVNNIKERVKELSFNEKEGVDLILNTLDSNEYMGSNFKALDIGGRIVDLSITHLNQNDFMLNNHFKFNFAYSNVEFVFIRKQIVKKLLNIIAKGISNNSLETIPITEFSSENIKEAIEYINKRKHIGKIVVNNDINILERMISQQKNENSLVLKSDYHIKPSNVGKTVLITGQAGIVLELFKWFLKYSISIENVIILSRSSLRWELEYLINKFKNIKFHYKITDVSDPVSVDNSLEQVFSENPTITNVDTILHFVYQHATCREDEIDMNNLNISHGAKTMGAINLHNQSIKPSSVTAVIGSYNQCSYVCANKVLDGLASYRRSIGLPCTASNWGAFGGAGVVARNDTIWTFVEDQGLNAIPTSHALGALDLLIQNQHLSNNLIISNFNFKTFKELNQIHHDKFDFLLNQINNSNDLKLSQADIGDAFLEKISESLSIDKQKLDLETQLGSFGIDSLVLVQLKNWVDKEVTPNIINTQQLSNNKISVTINVIKKEFEKKKNDKKK
The following text describes a protein:
Function:
Part of an ATP-driven transport system HI_0359/HI_0360/HI_0361/HI_0362 for iron. Probably responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MDSFSTSIWVNDVTVRYNNGHTAIHNMTFSLNSGTICALVGVNGSGKSTLFKSIMGLVKPQQGEIKLCDLPISQALKRNLVAYVPQSEEVDWQFPVSVYDVVMMGRYGYMNFLRIPKAIDKQKVQEAMQRVNIEHLAHRQIGELSGGQKKRVFLARALAQQSPIILLDEPFTGVDVKTENAIVDLLQQLREEGHLILVSTHNLGSVPDFCDQVVMINRTVIAAGKTEDTFNQHNLEIVFGGVLRHIKLLGENLHNDEDKRSVTVLTDDEKAVVFYGETKQDPPAPTTQNCHFEDCPYKSAVKNKRD
The following text describes a protein:
Function:
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MDKERILTPAVVFSVALLHLAMVALLWQAHKLPVIESGNVIEFVDLGDFGGGDGAPEGAGAPAAPEPQPVPEPPKPVEPPKPVLKPVVTKKADADIQQPKEEPKPEEKPKPEEKPKPEPKPEAKPVPKPAEKPVEKPSEKPAEHPGNASAKADSEQGNGEDKGTGTKGDGTGRGEGSGKGSGGVKGEHGEGAGSSKGNPLRANGSIPRPAYPTLSMENDEQGTVVLSVLVSPGGHVESVKIVKSSGFSRLDNAARKAAQNGHFQANAWTEFKVPVKFELN
The following text describes a protein:
Function:
Binds predominantly GDP, and also GTP. Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MEAGGEREELAHLRSVFAACDANRSGRLEREEFGALCAELRVRPADAEAVFQRLDADRDGAITFQEFARGFRGARRGGRPPAGAPRRPAPAPAPAPCSASAAPDPEDGGEDEGEEGEGEGEGDGDARAAAWGRASPGQAWRDFQERLGDEAKFIPRKEQVSTLYLNINLVEPRLIQPYEHVIRNFIREIKLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAVEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRISQKEDVAALKKQIYDLSMENQKVKKDLLEAQTSIAFLQSELDALKSDYADQSLNSERDLEIIREYTEDRNSLERQIEILQTANRKLHDSNDGLRTALENSYSKFNRSLRINNISPGNTISRSSPKFNGHSPQPLGYDRSSHSSYMDEDCDSLALCDPMQRMNCEVDSLPESCFDSGLSTLRDYNEYDSEVEYKHQRGLRRSHGTQESFGGDASDIDVPDIRDEETFGAEGVAAILDWKPHGSPSEGSVVSSSRKPISALSPQTDMVDGTHKSSSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRGNTSATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRRADGVLLLYDVTCEKSFLNVREWVDMIEDAIQESIPIMLVGNKADLRDAATAEEQKCVPGYLGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDEDDSKSITNLTGTSSRKSTQMKNCCSS
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). Also, regulatory component of the CSP25-plasmepsin PMV complex which cleaves the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence of several proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Partially colocalizes with plasmepsin PMV in the endoplasmic reticulum. Partially colocalizes with SEC11/SPC21 in the endoplasmic reticulum.
Sequence:
MSGNNVQEEDSTFHVSNLYSETEIKKITQDFISEKIREQNFEEIVKYSNIRIFLSLVLIVIGTYCSIFVQYKKNPVIMIQLLVAFFVVSTTLIIFEYFFFDDVFMILRSNNGSLVKLYCRLDVKKSTLILAYKLNKNVFETSFELKRLYNENGYLMKPYAKNVVMNFLSAHGRTLKLKN
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEQAVSMRQTGEVICRLHMWNRDGLSTAANSHYECINRPPLSIRTNLTHFCSCPCDSSERSSPDNYASSVASDSNGGGIGARNGHPLRYSSNVHLLDENVNLISTESVAQLDTAMGRCGEIIGDHREELLMVFTNNSDMLSSLFYEYDTPWILGKNTKTSMDFSKCEDLGKDYLIMLKISTKVLQSMFCQFCGQNQPFFQTKKDYFQQFAKSPIKKMLEIALSFSESNWSEEHIRPMLLAYDTLQDVLPTIRELSPDEPDEFFTSILHNMRNASRGIIDNMKRFIQHKVQTWDNIAIHPTTCFLINAIKIFNVHKNLLHSTLVPGDGQDSFGYLINGVIACWKLKIKELSMLDDPDKNDSDGNNPNLFIFLLNNIKHFNRDTNGLLDGLLVHRELIEECKNEFQSDMENYTSRYMTASWGPAISCLNNHTGGSIRQSMNAFISKFEGTFDCQKVLKVPDSELKQKLRDDIENLIFPAYEISFEELQRNSNSGLFCSCFPRNLTCSMYTPEILRRSVQGLFEG
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MKLSWSLFCGLASLALSQFDEAPPSQSDYFVRHIPGLDSVDNYTMHSGNILTDAAHNGNLFFWLVEAQYKITERPKTIVWFNGGPGCSSMDGALLEVGPFRIVDDKLRVDPNKGSWHKYANVLFVDQPYGTGYSYSDTDSYLTGLGQVGDEMDSFMTQFLKLFPERAHDDFYLAGESYAGQYIPYIATKLQQTRTVDLKGLLIGNGWMDPANQYYQYVPYALDYGVIEKTEEHVKDLKELTDTCERAINIAKDKNNGRLPVHIRACEDIMNGIVELSRNERSAPESEGICVNYYDVSKEDKWPSCGMNWPEILPYVTDWLRQDATVQALNVNNDKQESWQECNGAVGSRMRQGNDDAAVYLLPDLLESMEILFFNGDRDLICNHYGNERMIEQLEWNGKKGWTEGLELDDWVVDGVSKGKKQSDRNLTYVRIYNASHMVPYDEPEACLTMLNDFIGVSKALSDLSGNKPGRGSENPSDLDDQKSGDQKSDDDSSSDDDDDAEHDKKIASDAMWKAYYQAGFTALIVVLIILGLAGFLFWRKNRGHIYQEETSLLGSCFGGISRWRNSSGGPLSNQQGTFDSRQRLMEPGEYYDLGEIAEEDEDAEELVIRRPEV
The following text describes a protein:
Function:
Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B.
Sequence:
MMNLAINILQNDGGYTVQLNGEIDAYTASDLKNKIMPIASEKEVQIVVDFHNVDYMDSTGLGVFIALLKAVKKNDGKLEFIGVSKRLKRLFDITGLTEILNLNSDFEKVERR
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
METPSDNPPNVDSQNPATMSQPAAKDHDANPEATRENSPASVFVNSEPVREEQVENAVKFLSHPRVKESPVMYRRSFLERKGLTKEEIDEAFRRVPDPAPTVSTTQPVSANEDEKVKSPSTTQALSASQNLQFASAQQSNTMRKRGYFSHFHWIHAVMAVGIMAASGAGTALLLKHIIIPRFKSWIRKVVMEEEDEKGTLKGRPSLAEEAAVAAKAAAAAAVDVARASQEMLASKTEEKRYFEELTNLLNYQVQEMKSMSSALQKLEGKSSTSGRIPAMERDDKRVSISNSTDINDQPPNPYQPVPNPRFGPKPKPWEIGQNQNSSRSFFQSQGSGDGLNYEYQDSSTPWWQRKSGRITVTEAENEEKFGYTAAPTEVRPVQRSWVPPQPPPVAMAEAAAAIRQPKKSLLQKEKLTSDELRASSSEMSDDDLQRITKISESGGLTETNRSGFGQQLSGTPITNGDNVLNS
The following text describes a protein:
Function:
Involved in heme d1 biosynthesis. Catalyzes the decarboxylation of siroheme into didecarboxysiroheme (By similarity).
Sequence:
MDEFDRRLLNRLQHGLPLEPHPYALLAAELDCREEDILRRLDDLLDDGTLTRFGPLFDIEPLGGAFTLAAMSVPEARFEEIAALLAGWPQVAHNYRREHALNMWLVVACDSPAEVAETLARLERESGLAVLDLPKEATYHVGLHFPL
The following text describes a protein:
Function:
Regulatory light chain of myosin. Does not bind calcium.
Sequence:
MPPKKPEPKKEAAKAAPAPAPAPAPAPAPPPEPAKEPTFDPKSIKIDFTADQIEEFKEAFSLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNAKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMSG
The following text describes a protein:
Function:
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MGLAGGARVVLFVVAAAAAAALTAAADQIFTSSGAPFGRNSREPRYHVEFHPVDAPFNPENGQESVPMTSHVGKHYTCFLPVEETKTMKSIIPQNATNVIIESERRVKPKDPDELLEILKDQCFYRHEGWWSYEFCYYGKIRQVHVEGEKVIQEYVLGEYDADATDAYYENQTSDSADEDDNLIDTSKRYHVHLYTNGTVCDLTDMPRETEVRFVCSEPTVVISSIKEISSCKYVLTVQSPMLCKNPLFQQEKRTLSIHCNELLAEAEATVDDDSLPKEAQIIIPDPDGLHNYAAYAT
The following text describes a protein:
Function:
Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.
Subcellular Localization:
Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription.
Sequence:
MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEVNLDDSIDIQQQDMDIDEGQDGVEEEVFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPTPVEKETVVTTQAEVFPPPVAMLQIPVAPAVPTVSLVPPAFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPSLSMTPETVKDVGFGSLVIPGGSVASNLATSALPAGNVFNAPTKQAEPEEKVPHLIDHQISSGENTRSVIPNDISSNAAILGGQPPNVTSNSGILGVQRPNVSSNSEILGVRPSNVSSSSGIIAAQPPNILNNSGILGIQPPSVSNSSGLLGVLPPNIPNNSGLVGVQPPNVPNTPGLLGTQPPAGPQNLPPLSIPNQRMPTMPMLDIRPGLIPQAPGPRFPLIQPGIPPQRGIPPPSVLDSALHPPPRGPFPPGDIFSQPERPFLAPGRQSVDNVTNPEKRIPLGNDNIQQEGDRDYRFPPIETRESISRPPPVDVRDVVGRPIDPREGPGRPPLDGRDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGHRGDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWVPPPHARVFDYFEGATSQRKGDNVPQVNGENTERHAQPPPIPVQNDPELYEKLTSSNEINKEKSDTVADIESEPVVESTETEGT
The following text describes a protein:
Function:
Under acidic conditions, in the presence of lysine, functions as a cadaverine:lysine antiporter that facilitates the excretion of cadaverine and the uptake of lysine. At neutral pH, also catalyzes the uptake of cadaverine via a proton symport mechanism, however the physiological relevance of this uptake activity is probably negligible because the expression of cadB is low at neutral pH. Cadaverine uptake activity is low at acidic pH.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Amino acid residues involved in both uptake and excretion, or solely in excretion, are located in the cytoplasmic loops and the cytoplasmic side of transmembrane segments, whereas residues involved in uptake are located in the periplasmic loops and the transmembrane segments. The SH-group of Cys-370 seems to be important for both uptake and excretion and may be necessary for recognition of the NH(2)-group of cadaverine.
Sequence:
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVPAGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVMTAIVGWHWFDAATYAANWNTADTTDGHAIIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQVLSGMYPSSVMAASGAPFAISASTILGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDSNGIPKKGLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGVNIRNFVSLICSVLGCVFCFIALMGASSFELAGTFIVSLIILMFYARKMHERQSHSMDNHTASNAH
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MSSDMRRGVTSRMLYPYPEQEKIYPVVILDTTAGDMTLEFFFNESPKTCHSFLEHCRKGYYDLCLFNRIQKGLWVQCGDPTSTGRGGESIYGYGSGELLHKCRPTFEDELSHLKHNKAGVVSMCNKRKPDTNGSQFYITLGPCPWLDDVQLAMKDRNFNLSPDNTVLGLHTIFAQVVKGLDVLRRMNVLVVNKYDRPNKLTKLIRTLVVERPRHYEWRPYAESYGCFNLKGSHLAGKVEPGISVRKKKLERGSFKVVKRVSAAFVKPTHQGGWEVYRKRAF
The following text describes a protein:
Function:
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MLCIKKPSVASAFNELIPKILKDGEVVETEFEERTKEIRNTIIEITNPKLKKVPEKYPLGEKAVEEYTKNLLYGSKNVFSYDYHQRLFEYPYADEKINQIDYIIEKLNQQKNSRRAVAITWNPKIDIEVSRDERGSVPCLQLVQFLIRNGKLYQTVIFRSNDALLAFVSNAIGLITLGEYIAKKVGVGYGTYTHHAISMHIYVDRDFDYIKKYFPECLKYLW
The following text describes a protein:
Function:
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion (By similarity).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Secreted.
Domain:
The C-terminal region binds to collagen; The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme (By similarity).
Sequence:
MHPGVLAAFLFLSWTRCWSLPVPNDDDDDDDMSEEDFQLAERYLKSYYYPLNPAGILKKTAANSVVDRLREMQSFFGLEVTGKLDDNTLDIMKKPRCGVPDVGEYNVFPRTLKWPKMNLTYRIVNYTPDLTHSEVEKAFKKAFKVWSDVTPLNFTRLYNGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFVLPDDDVQGIQYLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMVFKDRFFWRLHPQLVDAELFLTKSFWPELPNRIDAAYEHPSKDLIFIFRGRKFWALNGYDILEGYPQKISELGFPKDVKKISAAVHFEDTGKTLFFSGNQVWRYDDTNRMMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPTNSLLWC
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MELNPVDSILSDRIQAIVATEKNIDDMMKCAREIMQDLGKEKQISKNKMDDNANSFKKLITQVENELSAQMQYLSHVCVGSSHQGSTFGVLQNSLLAQSGLSSLHSELAQILKNIEPPTQEVDEDNEDEEDSGDADMLEETPEDVVAPRTTSSSATTSDGGSGGADDAASSSAPRSQEERRSTEEEEGEQMEN
The following text describes a protein:
Function:
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDPMITGLGVVALMGAAATIAGAAEDLESDVGSQSNPNSQVQLAPQMGHLHRIINKAVSGEPVAYGTWCGIAGSVAFVLMNSMQLPVIMAIAIGAVIAAMVHTTYAVTSHMGRIVSQSQFNQPLFMDMLVQHLGPIAGHGFIVTFCTVGLSYLMTLPIPGFAHPFPLPLLAVLWGITIGAIGSSTGDVHYGAEREYQQYPFGGGIPVAIHGDITTKAELGARNSMDVVHFCAKYGGPLTGFAFGAIVFLSFWNTIVFGITGGIISGLIIVLLLIILNNRLEVFARNRYGPYKEEE