lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm. Nucleus.
Sequence:
MEDYLQDCRAALQESRPLHVVLGNEACDLDSVVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALHQAGQLTLILVDHHILPKSDTALEEAVAEVLDHRPIEQKHCPPCHVSVELVGSCATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTIYRQGVKVAISAVYMDLEAFLERSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLAIFCPHVALRTTICGVLECSHSPPLKLTPASSTHPNLHAYLQGNTQVSRKKLLPLLQEALSVYFDSMKIPSGQPETADVSREQVDKELDRASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK
The following text describes a protein:
Function:
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
Subcellular Localization:
Cytoplasm.
Sequence:
MCGIIGYIGDKNAIQIVLDGLKKLEYRGYDSAGIACLLNGKIKTVKCKGKIKNLESLVDDSLKQSKIAIGHTRWATHGKPSDENAHPHCSGSIALVHNGIIENYAEIKKELQTEGYKFVSQTDTEVIAHLIRKYRENNLSLEDSIRKAVSRLRGSYAIVIMDDKEPDKLIGVRMESPLVVGISDGEKFIASDVPAFLNHCNKALFLEDGEMIVLNKEGFRVYNLEGKEKKKTPITITWTASMAEKGGFKHFMLKEIYEQPRALSDTIRGRVLSDQGKIVFEEFGLTRDEMRRIEKIYLVACGTSYHACLIGEYIIENIAQIPVEVDIASEFRYRNIPFEKNSLFVAITQSGETADTLAALRYAKKFGVKTLSICNVLGSTASREADAVFYTHSGPEIGVASTKAFTCQIVALYILSIGLSIAKGVFPKIFIKNLLEELLLLPRMAEETLLLDKKIQLLAKEVYRKPNFLYLGRGVNYPVALEGALKLKEISYIHAEGYAAGEMKHGPIALVEEGFPVVFIASDDLYLEKTISNIEEIKARDGFIITISSSKEEKLKKLSDRFIYVEGINSYLNTVLFSIPLQLLAYHVALLRGCDVDQPRNLAKSVTVE
The following text describes a protein:
Function:
As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis; MISCELLANEOUS: Present with 784 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSNLVKEKAPVFPISKVKKIAKCDPEYVITSNVAISATAFAAELFVQNLVEESLVLAQLNSKGKTSLRLSLNSIEECVEKRDNFRFLEDAIKQLKKNSALDKKRELNMQPGRSDQEVVIEEPELHEDDGVEEEEEEDEVSEEEEPVHNEELLDDSKDQQNDKSTRSVASLLSRFQYKSALDVGEHSDSSDIEVDHTKSTDP
The following text describes a protein:
Function:
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
Subcellular Localization:
Cytoplasm. Secreted, extracellular space, extracellular matrix.
Sequence:
MEARMFWLLVVLLALASSSSAGEYVGLSANQCAVPAKDRVDCGYPQVTPEQCNNRGCCFDSSIPGVPWCFKPLQETECTF
The following text describes a protein:
Function:
Disease resistance protein of the TIR-NB-LRR-type. Part of the RPS6 locus that contains a cluster of several paralogous disease resistance (R) genes. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity). Required for [5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione-(DFPM-) induced root growth arrest due to reduced number of meristem cells in the division zone of the primary root and inhibition of abscisic acid- (ABA-) induced stomatal closing.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MASSSSSRNWVYDVFLSFSGKDVRVTFRSHFLKELDRKLISAFRDNEIERSHSLWPDLEQAIKDSRIAVVVFSKNYASSSWCLNELLEIVNCNDKIIIPVFYGVDPSQVRYQIGEFGSIFEKTCKRQTEEVKNQWKKALTDVANMLGFDSAKWDDEAKMIEEIANDVLAKLLLTSSTDSAENSIGIEDHIANMSVLLKLEAEEVRMVGIWGSSGIGKTTIARALFNQLSRHFPVSKFIDRAFVYKSRETYKGANPDDPNMKLHLQGCFLSEILGKKDIKIDHLGALGERLKHQKTLIIIDDLDDLVVLDSLVGKTNWFGCGSRIIVITNNKQFLRAHGIDHIYEVSLPSKERAQEMFCQSAFGENSPPEGFEELVVEIAWLAGSLPLGLTVFGSALRGRKKEYWVKMLPRLQNDLDGNIEETLKVSYDAIGNVKDQALFRLIACLFNHVKVRDIELLLADSGLDVNIALENLVDKSLIHVRNDHVEMHRLLQETGRNIVRSQSTDNPGEREFLVDSNDSRTVLSEGIGTRKVLGISLDTSKVSEFCVHENAFKGMGNLLFLDISSKTFIEEEVKVHLPEKINYYSVQPKQLIWDRFPLKCMPYTFLRNLVKLEMHDSKLEKLWEGAMSFTCLKELDMWASKYLKEIPDLSKATNIEKLDFGHCWSLVELPSSIRNLNKLLELNMEYCGELETLPTGFNLKSLDYLNFNECWKLRTFPEFATNISNLILAETSIEEYPSNLYFKNVRELSMGKADSDENKCQGVKPFMPMLSPTLTLLELWNIPNLVELSSSFQNLNNLERLDICYCRNLESLPTGINLESLVSLNLFGCSRLKRFPDISTNIKYLDLDQTGIEEVPWQIENFFNLTKLTMKGCRELKCVSLNIFKLKHLGEVSFSNCGALTRVDLSCYPSGVEMMKADNADIVSEETTSSLPDSCVLNVNFMDCVNLDREPVLHQQSIIFNSMILPGEEVPSYFTYRTSDSQPFGTSSSLPIPLLPTQLSQPFFRFRVCAVVSASNGVYIGVYSRFKGRIGNKFDSFGEVHNFMEIEKGIHLCIFDCRIRLYKDNVPLSQLNYDHVDINIHITSGDWRSTVVLKEWGIRLLETGSSAENRLGNPNSTLPHVSQAEEGNMGYYTHVQGLVNEIENSEDSGDNNVETERSKKRMRLHHFI
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MKINQGIFFDTSSICAVFINVLLITLIFKRSPKLLGSYKSLMIYINVFELTYAILYFAEKPNPFTKKSAFFLIVNWKESIFPKPISCLLNLLFVGFYGTTIAILALHFVYRFLSVTCNKLLNSFNSWKIILWFALPLLNGTMFMLIGSFVMCSSPESDRFMKENYQAVRENTTSFEDLYYLGPFLWPKLGNSSTEQYFSWKDAIGGMAITGAIGLSCFLMLYLGLRCYRCINATISTASSSSHLKTIQKQLLNALVFQSLIPVLLLHIPASIIFVTIFLGKSTEAIGETVSLTVAWYPALNPLPALFIIKSYRDTIGGFLVALLRRVVPRTNVVATYEHPSPGSPAIRETTVNNLNKITLT
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MAQKREKEETELKVPESIPLCSPTLPISAPPPHLSANDTKRSPEISDLKLSASSLERIDLKLSTSSLERIDMKLSGTNESRSSSDSSPESIDPKLSSSDSSSESLDLKISDTDESRSTSATSPESTDLVGRKAATKRPREANRCCGIGCRRKVGLIGFRCRCGEVFCYEHRYSDRHSCSYDYKAAGREAIARENPVVRAAKLVKV
The following text describes a protein:
Function:
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Sequence:
MNTVNYLRISLVDRCNFRCSYCMPTGEAIAYLHRSQILSYEELLFLVGEVFLPLGIDRFRLTGGEPLLRRGVVGFVRALVGLPGVADVSLSTNAYLLEELAEDLYAAGLRRVNISLDSLDPGVFARITGRDHWSKVWAGIQAAHRVGFDPLKLNVVVLPGINEQEVPDLAALTIDRQWHVRFIEFMPIGNTGYFEQAGWVNSETLRSRIRERFGLGEGACYGNGPADVFQIPGAKGTVGFISQMSECFCSRCNRVRLAADGFLRPCLLNEADQIDLKTPLRAGAGAAQLRELVSELLLRKPEINFRERDRGTTGSYGRTMSQIGG
The following text describes a protein:
Function:
Has a role in pre-mRNA splicing where it is involved in spliceosome assembly.
Subcellular Localization:
Nucleus.
Sequence:
MSETRLFVGRIPPQATREDMMDFFKGYGQILDCKLMNGFGFVEVEDARDARDIVNDFQGKEFMGSRIVVEPARGERRRRENFRESAASKYPRPRRTGFRLIVENLSEDVSWQDLKDVMRKAGEPTFTDAHRENPGAGVVEFSTEEDMRNALTSLNGEVIKGQAVTLREDPDAANEPLPEVPSRFRSRSPPARRRYRDDYRRGGDYRRDAYRPGRDDERRYAPRGEYRRNNRDEYRRGGRDEYRRNSRSDYRRPHDDEYRRPRGDEYRPGRDEYRRSRDDGRPSHDDEYRRDAYSRSPSPRRDREENRSPAYEGSKSYSAAPEASMESSAPTESYDKPAASEEQQPLQNHSDVGNGSAEGQVAAEW
The following text describes a protein:
Function:
Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9. Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis. Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron during embryogenesis. During larval development, required for the elimination of transient presynaptic components upstream of ced-9, ced-4 and ced-3 apoptotic pathway. Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3 and ced-4, regulates temporal cell fate patterning during larval development. Has been shown in two studies to be dispensable in mitochondrial dynamics and morphology during early embryonic development. However, one study shows that during larval development, egl-1 is involved in modulating mitochondrial dynamics, perhaps acting by stabilizing the interaction between ced-9 and drp-1 in order to promote mitochondrial fission. Involved in inducing mitochondrial fragmentation during apoptosis, probably acting via ced-9 and dynamin-related protein drp-1.
Subcellular Localization:
Synapse. Note=Localizes to RMED/V synaptic regions in L1 larvae.
Sequence:
MLMLTFASTSSDLLPMSNVFDVQSSVFYNEKNMFYSSSQDFSSCEDSSQFADDSGFFDDSEISSIGYEIGSKLAAMCDDFDAQMMSYSAHASDRSLFHRLLDFFAF
The following text describes a protein:
Function:
Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity).
Subcellular Localization:
Cell projection, microvillus membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells.
Domain:
The extracellular domain mediates homodimerization. One or more cysteines in the extracellular domain is essential for the formation of dimers probably by forming a disulfide bond; The cytoplasmic domain mediates the interaction with LCK.
Sequence:
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MASAATFPKLRLAPRFRTYSQFQMTDLVHIHIKTGDGCNRPTHAHGWLISTGRSLRHTFLPVSAVRSGRGSSVAQEEEKTGLSLDNFKTTVVSRDDENINLRIDLPGKATQKVFDEALTSLARDAPPVPGFRRSKGGKTSNIPSSILLAMLGKSRVTKFILQEILSVTVGDFVKKENLKVNPEIATTQSEGDLESSFTPGSSFRFNVILQLEKESDSDEASEEVQVDSDEASGEVQADSDVATEEDPSS
The following text describes a protein:
Function:
During the asexual blood stage, plays an essential role in the export of several proteins into the host erythrocytes by cleaving the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence. Specifically, cleaves after the leucine residue in the RxLxE/Q/D (or RxLxxE) motif of exported proteins including RESA, EMP2, EMP3, KAHRP, RIF/Rifin and STEVOR (By similarity). Also, by regulating protein export, plays an essential role in gametocyte development and thus parasite transmission to the mosquito vector.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=During gametogenesis, localizes to the perinuclear ER in stage I-II gametocytes, and relocalizes towards the cell periphery as the ER redistributes in the cell in stage III-IV gametocytes.
Domain:
The transmembrane domain is essential for localization to the endoplasmic reticulum.
Sequence:
MNNYFLRKENFFILFCFVFVSIFFVSNVTIIKCNNVENKIDNVGKKIENVGKKIGDMENKNDNVENKNDNVGNKNDNVKNASSDLYKYKLYGDIDEYAYYFLDIDIGKPSQRISLILDTGSSSLSFPCNGCKDCGIHMEKPYNLNYSKTSSILYCNKSNCPYGLKCVGNKCEYLQSYCEGSQIYGFYFSDIVTLPSYNNKNKISFEKLMGCHMHEESLFLHQQATGVLGFSLTKPNGVPTFVDLLFKHTPSLKPIYSICVSEHGGELIIGGYEPDYFLSNQKEKQKMDKSDNNSSNKGNVSIKLKNNDKNDDEENNSKDVIVSNNVEDIVWQAITRKYYYYIKIYGLDLYGTNIMDKKELDMLVDSGSTFTHIPENIYNQINYYLDILCIHDMTNIYEINKRLKLTNESLNKPLVYFEDFKTALKNIIQNENLCIKIVDGVQCWKSLENLPNLYITLSNNYKMIWKPSSYLYKKESFWCKGLEKQVNNKPILGLTFFKNKQVIFDLQQNQIAFIESKCPSNLTSSRPRTFNEYREKENIFLKVSYINLYCLWLLLALTILLSLILYVRKMFYMDYFPLSDQNKSPIQEST
The following text describes a protein:
Function:
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Subcellular Localization:
Mitochondrion.
Sequence:
MSCWTTSAASVRAVAPRLLRAPSAASTLPSQLLATSISRVATAAASSSSSPSSSRHIFSSARLKNNTAAPSKTVSGQDISIALDDKGQIPAAPYSQLPLAGTSPSYKVHLIVHPYDHPRPVESWPSHLESVSPLLSELESRAKKGGSLEGYGISFSSGDGRTGTGTGTRSEALKPWDATTSRMMRSVPNSAQEQEQFLVYAYTTNGTMAKVGPISLATLDSGSPFRQRIDDALASAQPQTGRAKQDDETHVYVCTHGARDCRCGVAGTAVYEALKDEVRSHQASIIKSGKDAPKKVKVFAVSHVGGHAWAANALVYPHGDWYGNLRVTDSKLVLRAALAPASSMHDLDDLRERLVHWPRWRGRLGLSKAAQRDHYAEWGPPTINTAHITPRSRGTASSARSRPSLAALSTPGHAHASTSSARTYATDASDSKKKAPSARMVAFREKLAADLSIDDFAAGEVDSIMTSASASGRVQMGRTGEARLPSHLKTKIPTGANYTRIKSDLRGLGLSTVCEEARCPNIGECWGGSGGKDTATATIMIMGDTCTRGCRFCAVKTSRAPAPLDPHEPENTAEAISRWGLGYIVLTSVDRDDIADGGASHIASTISKIKAKSRKILVEALVPDFSGDMACVEKVAHSGVDVFAHNVETVERTTPMVRDRRAKYRQSLAVLLHAKQANPALITKTSIMLGCGERDDEVEQTLRDLRNAHVDVVTFGQYMRPTKRHMKVHQYVSPDMFLHWQKRAEHLGFLYVASGPLVRSSYKAGEFFIKNVLEQRNSAHNLYPTSEQAVQSTTS
The following text describes a protein:
Function:
Might play a role in mitosis. Could be a centromere-associated protein. Antigenic molecule. May induce anti-centromere antibodies.
Miscellaneous:
MISCELLANEOUS: Two ORFs are contained in the Sssca1 gene, but only this protein is efficiently translated and expressed.
Subcellular Localization:
Cytoplasm.
Sequence:
MALNGADVDDFTWEPPTEAETKVLQARRERQDRISRLMGDYLLRGYRMLGDTCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQAREHQLASSTEPASSSRPPSQPPVPRPEHCEGAAAGLKAAQAPPLPAAPPNTDAVASTQTALLQKLTWASVELGSSTSLETSIQLCGLIRACAEALGSLKQLDH
The following text describes a protein:
Function:
Nuclear receptor which acts as a transcription activator. Binds small molecule ligands, such as phenazine 1-carboxamide (PCN), a pathogen-derived metabolite, leading to modulation of innate immune responses against virulent pathogens. On exposure to exogenous PCN, P.aeruginosa and other xenobiotic immunostimulant such as R24, activates immune response genes, including irg-4, irg-5, mul-1, drd-50, cyp-35C1 and ugt-30, probably via direct interaction with their promoters, and independent of the p38 MAPK pmk-1 pathway. Exhibits higher affinity to R24 than PCN and thus induces stronger immune response. Binds its own promoter thereby autoregulating its expression in the head hypodermis and the pharynx. Possibly plays a role in lipid storage or catabolism.
Subcellular Localization:
Nucleus.
Domain:
Ligand-binding domain exhibits affinity for phenazine 1-carboxamide (PCN) and xenobiotic immunostimulant R24.
Sequence:
MEPLDNTSLEESQFRPEKKEKSTCSICREDGDGYHFGAEACRACAAFFRRSVSLDKTYLCRGNNDCEITANIRCMCRSCRFAKCLEVGMNPAGVQQRRDTIGKREIKPDSTDLMQLLGSVGDGYPPTTSAQSALVEDLHPSFNDRMPILMKMRVNYRKMDNARLVIHRKDGQSLFKEKTPKAVNYKEACAQSIREVSLVADWVAWCFDDFVTLPMDQKKVLFRNFYTPFSVLEGAFLCHINDTSNALILPSGDYIDTNNLKSFFNIPDEEQPMTDDEIEKFCRMFKPSFELNRRGLVLPMMAEKIDVFEFFALCTFVFWDFGLDEQTDDCMMIGKSVKDRVMKELAFYLRCAKRLEEPSLRVASLLTLLPALQRCVRRFQEDIEITNVFNVYAPPKDFYDLVNGKFC
The following text describes a protein:
Function:
Transcription factor involved in the regulation of tapetum programmed cell death (PCD) and degradation during male reproductive development. Interacts with TDR and promote tapetal PCD by regulating the expression of RTS, and the two lipid-transfer proteins C4 and C6, which function in microspore development. Acts downstream from and interacts with TDR in the regulation of tapetal PCD. Regulates directly the aspartic protease AP25 and AP37 during tapetal PCD. May not target the cysteine protease CP1.
Subcellular Localization:
Nucleus.
Sequence:
MIVGAGYFEDSHDQSLMAGSLIHDSNQAPASSENTSIDLQKFKVHPYSTEALSNTANLAEAARAINHLQHQLEIDLEQEVPPVETANWDPAICTIPDHIINHQFSEDPQNILVEQQIQQYDSALYPNGVYTPAPDLLNLMQCTMAPAFPATTSVFGDTTLNGTNYLDLNGELTGVAAVPDSGSGLMFASDSALQLGYHGTQSHLIKDICHSLPQNYGLFPSEDERDVIIGVGSGDLFQEIDDRQFDSVLECRRGKGEFGKGKGKANFATERERREQLNVKFRTLRMLFPNPTKNDRASIVGDAIEYIDELNRTVKELKILVEQKRHGNNRRKVLKLDQEAAADGESSSMRPVRDDQDNQLHGAIRSSWVQRRSKECHVDVRIVDDEVNIKLTEKKKANSLLHAAKVLDEFQLELIHVVGGIIGDHHIFMFNTKVSEGSAVYACAVAKKLLQAVDVQHQALDIFN
The following text describes a protein:
Function:
Possible regulatory or functional link with the histocompatibility cluster.
Sequence:
MPRKTPISNKRRKEQLLVRRALKRGDISIEDHDAIRTQQKLKTEKRGPGAVAARSGGPVDTTSRKLQSKFIALSADYVARTRDLAYALPLQRPLAPESAVFPLEILQDRDPKRRLRCPSRPKFRYGQTKTEVEKNEEGVFKKWLKDIEEVVHEWVDGDEEQVYVGESIYQVPRGPTWFETNLEVWRQFWRVTEASQILLLLLDSRCPPLHCPPSLRTHLKSLVPSKEIILVLTKSDLVDSKALEGWKKWVRSWWGQESVHIVSVRSYDTELLREGKGRHKPDIPQQSLDELISALQAAHERLLHSPNRDKDDKELDNWKPPVRSSVDWASLKDEDHIPDPRVDTVEENIGPQNSVGKLPSGQGDEQSTPEEAKAPSTEPLTLGLIGQPNVGKSSLLNALLGEQKVRASRTPGKTKHFQTMFWGPKKEIKIVDCPGLVCPSLAGLEIQAMAGIIPIAQIPSLPSCILFASAHMPIEAIFRVHLDIDVQDDTGAFASKKTYRNAEQAERAKQREEEERRGVRWTVGGVLEARALDKGFMTAKGGRPDINRAANGMMRALADGKVKWGFYPPGMTGKTDMGIWLGDDDPEGVEEGDTAGASWDERNDDDEGFISEESEFADQRANEEVEAEEVESQQSGEEATSSNVKQIGGFFAALEVSDNEEEGSEDEDIGDANE
The following text describes a protein:
Function:
Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Together with su(sable), part of a transcription termination checkpoint that promotes transcription termination of aberrant RNAs and their subsequent degradation by the nuclear exosome.
Subcellular Localization:
Nucleus.
Sequence:
MKIKLIDSVVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTKVDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPIAAYDPEGLIFAAGVNSESIKLYDLRSFDKGPFVTFKLNQEKECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNNKGIPIEASFSPDSQFIFSGSTDGRVHIWNADTGNKVSVLNGDHPGPVQCVQFNPKYMMLASACTNMAFWLPTSEEGL
The following text describes a protein:
Function:
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRANSRMGSRPVSAAGGGPAPLQGFGRTNHDTSNRTTLPPSQVLGRGRYKPVKAKASYVDESLFGEPSRKSASERQQQQTKWAAPWHEPSSRPTSSAKASRAQPSDRTSWLQSAQPRSMRAVDPGKYKSTDPWNGPLTNTAPPAKGARKAMPSDPWRGSGFHQANPARRGLAKPPAATIDLTQDKR
The following text describes a protein:
Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Subcellular Localization:
Membrane; Single-pass type III membrane protein.
Sequence:
MPGIQRAPDFLSPSEDQVLRPALGSSVALNCTTWVVSGPHCSLPSVQWLKDGLPLGNGGHYSLYEYSWVKANLSEVLVSSVLGVNVTSAEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEMNDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEMQLALPRKVRYRPVEGDPQTQLQDDKDPMLILRGRVPEGRALDSEVDPDPEGDLGVRGPVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Subcellular Localization:
Plastid, chloroplast stroma, chloroplast nucleoid.
Sequence:
MHLALLISRIRLLPTAMPSTRSASASRLLVRADNSPVAREIKRESSVSLDTPKPEATVSVKRRRVKRELEVNGQHHKKQVPDIEDFIYEKAKTLTSSSKATTSLVKVEKKVGVSSVIKVGAPDNWEAVLGGIKSMRLSGEAPVDTKGCEKAGSLLPPKERRFAVLISTMMSSQTKDEVTHAAVERLSENGLLDPDAIVRTDETTLANLIKPVGFYQRKAQFIKEASKICLERFGGDIPDSLNELLALRGVGPKMAHLVIIYLFCPLWLKYEHIYLHGYLSLTKQVMSIAWKNTQGICVDTHVHRISNRLGWVFREGTRQKTTTPEQTRISLEKWLPKDEWEPINPLLVGFGQTICTPLRPKCDKCGINNICPSAFKESSSPIPKQKKTRSP
The following text describes a protein:
Function:
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKPLGDRVVIEVLEAEEKTASGIVLPDSAKEKPQSGKIVAVGSGRVLDNGTKEPLEVAEGDTVIFAKYSGTEVTYEGTDYLILRESDILAITK
The following text describes a protein:
Function:
Transcription factor that positively regulates the cluster that mediate the production of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol).
Subcellular Localization:
Nucleus.
Sequence:
MAPKDSQVSASNEMTGNPPSSVQGRSRNGCITCRIRRVKCDEERPHCRRCQSTGRKCDGYTPLTGQQPKQQPPQQAAKAGSSELRIIQHTPQVTQPTQLCMFPGVDTLLTEDEYRALEFFNVQTVSCFGPRAGGWLLNAACQDSAIRRAAMALGTMHRVVLYHSRTPPHDRRRGMQLALQQYNSAIRQGLKLFAGSNDSSADGILSMCVLFFCLDSLQGHFRSALRHVGSGLRILAQRQLRGQRAENTLLPPDVIQSLFAALEAQMLEIDGQSPLLDENGLPVRGAGRPAPLWTLEEAQDTFRSIYNDFLRLLSFSARLEEPVDELEMVQIVEQVMARKQQVQTDLDAWSLEFDHFLAHIFHWGNQASQQSVRMLQLWRTMLTMVLHMGWPPQDTAWGSHLSELNIILDLAEQIIVMSPPLELESSAGSTFSLQGHSRAGSPSGSRSRSMSTSSSASRDDSPTTTTTTTTTPTPRLKKETDPQSTYTPILPRPFHSSPSRFTLALGILPALWTIATQCRDSSVRYRAIDLIGRSKRREGVWDSDLHFRLALQLARHEEQAAGLDAGAEYTHARIPPEARVTLNGRFDEGRKAKISYIRENVRVGEEIFHW