lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MHLTLTSLSVLRVVWGIVVPLEVTPVAYGTLAWTLGDTVLHGMMTTQREKRREVTLACLLLATAGCFADLNQIPQVTVQPSSTVQKLGGTVILGCVVEPPWMNTTWRLNGRELNGSDDALGILITRGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRDNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVAGYNKTRFLLSNLLIDATSEEDSGTYRCMADNGVGEPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLTSSQRLRLSRRALRVVSVGPEDEGVYQCMAENEVGSAHAVVQLRTARPGTTLRPWRDAKLDTATPPVLPSRPGSPDQMLRGHPGLPKPPTSVQPASPQCPEEKEGQVAPAEAPIILSSPRTSKTDSYELVWRPRHEGGSRAPILYYVVKHRKVTNSSDNWTVSSIAASQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGSNPQSSSQPDHGRLSPPEAPDRPTISMASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSSYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDRYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQLPPPETIERPVGTGAMVARSSDLPYLIVGVVLGSIVLIIVAFIPFCLWRAWSKQKHTTDLGFPRSALLSSSCQYTMVPLGGLPGHQANGQPYLSGTSRRACANGIHVNRGCPTAAMGYPGVKPQQHCPGVLQQQDDTSSLLKQTILGTEYDHTSHQVTRGPRSSPDEGSFLYTLPDDSTHQLLQPHQDCHHLQEQPAATGQSVMRNVPPSPGLEATWDPLFHRGPPCCLGLVPVEEVDSPNSCQMGGGDWRSQHPTGAYTGQELGMRLSPSPPVHISFETPPPTI
The following text describes a protein:
Function:
Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MDYLIFLLAILHVYKVLCEEMFWDTTVKLAKNMTLECVYPSTDTLTQMEWFKVNAMEKESLVIFNPTYGAIIRQPYADRVYFSNSTVTPNDMTLSFHNASEADVGFYSCFLHTFPHGPWEKVIQVVPPDSFEIDAPSNSDILSEPGKNVTLTCQLQMKWPLQQVTWEKIQPHQIDLLTTCNLSQGKSYTSKFRRQILSNCSQGMRRASIVLPHVTASDSGLYRCRFKASTGENETFVMKLTITDGKTDNRHILFVAGGTVLLLLFVILITTIIVILYKRRRRREKRVLVKESWDTQNKASNNYRSPIFTNQPSDDAREDIYVNYPTFSRRPKTRV
The following text describes a protein:
Function:
Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (By similarity). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form (By similarity). Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (By similarity). Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (By similarity). XPO4 then return to the nuclear compartment and mediate another round of transport (By similarity). The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4. Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (By similarity). Also mediates the nuclear import of SOX transcription factors SRY and SOX2.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MMAAALGPPEVIAQLENAAKVLMAPPSMVSNEQRQHAEHIFLSFRKSKSPFAVCRHILETSKVDYVLFQAATAIMEAVVREWVLLEKGSIESLRTFLLTYVLQRPNLQKYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSSSSKTSNIGLSMEFHGNCKRVFQEEDLRQIFMLTVGVLQEFSRRENLSAQMSSVFQRYLALANQVLSWNFLPPKLGRHYIAMFESSQNVLLKPTESWREALLDSRVMELFFTVHRKIREDSDMAQDSLQCLAQLASLHGPIFPDEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVRDDKHFHKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDRDQFSDQLASVGMLGRIAAEHCMPLLTSLLEERVTRLHGQLQRHQQQFLASPGSSTIDNKMLDDLYEDIHWLILVTGYLLADDTQGETPLIPPEIMEYSIKHSSEVDINTTLQILGSPGEKASSIPGYSRTDSVIRLLSAVLRVSEVESRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPLSTAFGADTEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLVIQCENWWNLAKQFASRSPPLNFLSSPVQRTLMKALVLGGFAHMDTETKQQYWTEVLQPLQQRFLRVINQENFQQMCQQEEVKQEITATLEALCGIAEATQIDNVAILFNFLMDFLNNCIGLMEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMHLYEACLTLLQVYSKNNLGRQRIDVTAEEEQYQDLLLIMELLTNLLSKEFIDFSDTDEVFRGHEPGQAAGRSVSAADVVLYGVNLILPLMSQDLLKFPTLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMTSMSSEVCQLCLEALTPLAEQCAKAQETDSPLFLATRHFLKLVFDMLVLQKHNTEMTTAAGEAFYTLVCLHQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASSTPPALDRKQKMAFLKSLEEFMANVGGLLCVK
The following text describes a protein:
Function:
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
LVFYNMSMFGNDCLFSEFQSSCSSDDEEDDSLLRQYKEENATLRKQNILYIHTVNIFTQPSFIKVKDAAKDGPIAHVLLFNNVTARKHANEIKNFFHEIASRPNLSDDYVLDSPQRSSVPYLPPKLKSYKSKRSSRDERKASKAYVVTNSFQVFSNYFYLDQIGESLSRDEKNESLLPSYERARPDPLDGEVDEADVNKISNKTMRACFNCGMNDHQIKDCPTPKNFKNINQRKMQFQERVNSSPQMGNSRYHADNDSDSERFSEFKPGVISSQLREALGIRDNQLPPYIYQMRWHGYPPGHMIDAKINSAGLNFYSEGRKSDSQDSEGQVDVDKIISYPGFNVPPAPQTVEDPSFPPMDDRHSKDVMVSYHMHKNELLKNKRNNVVPNPRKRQKVSHRVDNVDEVDMEIEDDSDPAEVVAGDARERGDQRIVIESSSVEEEEKEEGECDEMIDVDQYVVGLSQDELQVNTNDVTPDDVTPDNVTPADVTPDDVTTNDDVTPDDVTTNDVTPDDVTTNDVTPDDVTTNDVTPDDVTTNDVTPDDVTSDDVKVEGKETLTDDVIHNDVTSDDVTPNNETNTNEKMFAESTTTGHPSSVKDDSPNVDVTQLGKYGHDVTSQVTRGGVANHITGGMASKVDDSNQYDVDYLNNKKCVELRDIDVIIPQKDGTPHCDVITSKTDTVMSQSEQSSHTVQDYDVTNDDKTICDVTESVTMQNDVTNEPQSTTRDDVEGNNDVMDKVNNISLEPCAGNNDDSDVIMDGGSGEGNPENTGVPHRSKFAAGVTQFDAYYRETKSHGVFNKLKRLLRNSPRRQPKD
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTIEVVALFGILFALLAGGVWIGLTLALTATLLLAMFRSIPLDKLLPQYAWNILTTQELLALPLFILMGELLFRTRLSRSLFQGLAPWAGLLPGRLLHVNVIGCTIFAAISGSSAATTQVIGRMSLNELLRRGYSRDIAIGSLAGAGTLGFLIPPSNIMIIYGVLGDVSILKLFTAGVLPGLLLAATFMGWVMLHTTLKPSMVPETEAKLSQVPWGERFAALKDLAPALFLIACVLGSMYGGLATPSEAAAVGVLGAGLVAWAQGSMSQQVMRDVLIGSVVTCSMIALIVLGASILGNAAAFLGIPQAVAAFVKGLGLSPFMLIVVLIIFYLILGCFLDGFSMIVMTLPIVLPIVKGAGFDEIWFGIFLVLAVEMAQITPPVGFNLFVIQGLTEDGLGYIARVTMPYLMIMVGFVLLLTLWPGIVTILPRVLYG
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity).
Sequence:
MSKGEDKFSSVLKLTEFDYIVPSQICIKPVEIEKSNDSGNSKIQIESDGRYVEISEDGTKKSLEKATITLNDCLACSGCITSAESVLITAQSISEFLLNVNNNNDSNNNQDEKKTIVITLSPQSRASLASHFKISTLSVVKKLKTFFKKLNINYLFDSSFSRDFSLLESAAEFVARYKKTYINNNNDEETGKLEPFPLPMLSSACPGWICYAEKTHGEFILPFISTTKSPQQIMGTLVKYYFTEKILDNNTNNNNNNNNNNNNNNSKIKPSNIYHVTIMPCYDKKLEASRNDFYNDIFKTKDVDCVLSTTEILDLFKEKEIDFLSLEEDNSIEEQFFQLSPSNQFYSINGSSGGYLEFIYKYAAKELFNVDIVEPIQYKIGRNQDFKEVSLEIDGKKVLNFAQAYGFRNIQNIVRKIKTNITTKKDTNSQYDFVEIMACPSGCINGGGQIKSDAIKENKAILLDSEEKYNENVIFRQPIDNQSVQNIYNTWLNGCFSTDSKTNLHTQYHRIEKTTNALNIKW
The following text describes a protein:
Function:
May regulate leaf (and possibly other organ) development by functioning in cell wall loosening and cell wall expansion.
Sequence:
MEIKGYIVALIMAMTMMELASLTLATSRRSMLTNGIGLTPPMGWNSWNHFGCDVDEKMVKETADALVSTGLSKLGYVYVNIDDCWAEIARDDKGNIMPKNSTFPSGIKALADYVHSKGLKLGIYGDAGYYTCSKTMPGSLGFEEQDAKTFASWGIDYLKYDNCHHDGSKPIERYPVMTKALKKVGRPIFFSLCEWGEMHPAEWGFHVGNSWRTTCDITDTWESMISRADQNELYAQYARPGGWNDPDMLEIGNGGMTKDEYIVHFNLWAISKAPLLLGCDIRNMTQETIEIISNKEVIAVNQDSYGIQARKARMHGDEEIWVAPLSSYRTAVVILNRGSVRYSVTAFWEDMGLDPNTVVEARDLWEHKTLKNRFVGNITTMLNPHSCKMYVLKPVS
The following text describes a protein:
Function:
Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells (By similarity).
Subcellular Localization:
Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
Sequence:
MRHSLTKLLAASGRDFPSRRDSREPPATRAPPREPSGAAAGAETPRPGSPDREQPHGDGDGGEPEARSGSRGSVAVRAPAPSPLKMEEEEEDAIAMVPKEEPEDMDFLSGLELADLLDPRQPDWHLEPGLSSPGPLSSSGGGSESGGLLRGDDDDDTAAAEMQRFSDLLQRLLNGIGGCSSGGDRGGGEKRRRKSPGAGGGGANDGNQAATKSPRKAAAAAARLNRLKKKEYVMGLESRVRGLAAENQELRAENRELGKRVQALQEESRYLRAVLANETGLARLLSRLSGVGLRLTTSLFRDSPAGDHDYALPVGKQPPEPREEDDAAGGVCLHVDKDKVSVEFCSACARKASSSLKM
The following text describes a protein:
Function:
Non-reducing polyketide synthase; part of a gene cluster that mediates the biosynthesis of a yet unidentified natural product.
Sequence:
MNLLIFGDQTADQYALLRKACTWKNNAALTTFLDRISVVIRDEVQKLPRTQRDHIPDFLTTWDLVEAYYSKGLKLPQLESCMVTIAQLAHYIGYVQGLESFHGLTNPSRYYAENPSELPILANTRIVGLCTGLLAASVVASARSLSELLPLATEAVRLAFRAGTCVGSAKNALENATNPKESWSTIVTGISEQDAKTALAAFHNDRQIPASARAYVSAVSVMALTISGPPATTKRLFQEAESFNQADIDRILDKDAARHLQQFRPLALVHSATHGKCHTATNTLELVQIALGEILLEPVRWDSLLEQVVNEVTAASSAECTISAIGVTNIANSLVSALKAGGQTNVSVRDQSLWSATTDESRGRTQNDKIAIVGMSGRFPGAASPEKLWELLEKGLDVHREVPADRFDAKAHCDPSGKGKNKSHTPYGCFIDEPGLFDPRFFNMSPREAAQTDPMGRLALTTAYEALEMSGYTSDDWREINAAENIDTYFITGGVRAFAPGRINYYFKFSGPSYSIDTACSSSLAAIQLACTSLWAGDCDTACAGGLNVLTNPDIFSGLSKGQFLSKTGGCKTYDNDADGYCRGDGCGSVVLKRYEDAVADKDNILGCILGAATNHSAEAVSITHPHAGAQEFLYNRVLAKAGVDAHEISYVEMHGTGTQAGDGIEMTSVTNAFAPRHRQRRPEETLHLGAIKANIGHGEAASGINSLVKVLMMMKKDAIPANVGIKGVMNKTFPKDLLQRNVHISTKQVAWPRNGAEKRKIFLNNFSAAGGNTSLIIEDAPLPTAPKAADPRTMHTVTVTARSIASLKKNINNLMEFLDQNPDTTLPSLAYTTTARRIQHNYRVAICVSEISQVKDALQAQLKDSYSPLPMVPTKTAFTFTGQGSQYTGLGQKLYEELDTFKADIDELDNLARLHAMPSFLPLLTGEDVTTLSPVVVQLGMSCIQVALARMWASWGIVPTSVVGHSLGEYAALHVAGVISASDMVLLVGRRAELLVQECTANTHGMLAVKGSADSIKAALVDKMTEIACINGPEDTVLCGTVEIVHSTSELLSSKGFKATKLNVPFAFHSAQVEPIVEKFKAVASSVIFSKPSIPVMSPLTGEVIHEAGIIGPDYLARHARETVNFWTALSAGQDEKLFDAKTAWLEVGAHPVCSGMVKSTLSGAPVTATSLRRNEDSWKTLSNAVATLFLAGVYIDFNEFHRLFNDAHEMYTLPTYAFDSKKYWLDYHNNWTLTKGEVLEGSPVKAIEQAPIEIESKLKTTSCHKIIREELHANSGTIVVQSDLSDPQLKATITGHQVNGTPLTPSSLYADQCMTVADYLYQQLRPGMTTPGLNVRAMEVTKTLIPQYPPPAGGQHLQVEATADLELNQVDIKFRTVTADGSKVYAEHAVGVVMYEDIVAWKEEWSRIQYMVQSQIDMLQMKLETGAAHKVLRGMAYKLFKALVTYADNYRGMEEVILDGKQTEATAQVQFQTTAADGNFLCSPYWIDSLCHLSGFIVNASDHLDSENSVYISHGWGSVKISKKLSPEKKYRSYVRMQPAPGNISVGDVYIFEDKEIIGVVTGLKFQNIPRRALNIMMPPAGKSSGGAATTPVAKLIPKALPAAPVKKVQVAPVKATKAVAKAPGKAVKPAKVAKATSAGVTSKVMKIVAEEIDVDMSELVNDAAFENLGVDSLLSLTISARFREDLDMDISSSLFTDCPTVGELKKHFAQYDGGAVAVEDDDSSDTTDEPSDDSSTPYEIGTTSTPASSAPSVADDDIKPAGEVVEGEASVARKLVADEMGVDVSEITDDLDLTDIGMDSLMSLTILGSMREQTGRDLPADFLTVNVTIKDIETALGMRSKPKQQTKVVTKVSVKTSSKSPQLAEVNKKLEKTVDISGLPASNSVLLQGNPKVATKKFFLVPDGSGSATSYISIPNIDPDMAVYGLNCPFMKCPEKWTCGVEGVAQIYLNEIKRRQPEGPYLVGGWSAGGVMAYEVAKQLVNNGEKVESLVLIDAPCPVALDPLPARLHIFFDQIGLLGTGKPGGTPSWLLPHFASAIQNLKDYDPTPMDPKIAPPVLAIWCTDGVCPNPDDPRPPPGEGEDPAPMKWLLNNRTIFDDNGWAQLLPKENFEYGVMGGNHFTMMKGEHGATLGKLIKKGLKL
The following text describes a protein:
Function:
Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome membrane; Single-pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MSFKFLIESLLLGSISGQIRCGRSSVIPRGDVSYGGDDTDELNMDIMLFAFGTLIVVYIVICIVYFFTKQIATRLITAYYNEHGPGQRISLFSDYDENNAHVHSRRLMENMSLRWPNNLDDADEVRDKLAQLSPEEQFYYKQGEEYIKQNPPFLLNQGLLQQSEDSNPDTTREDPIMNEQTRQYIQEEGAYAWEFSPNPDMPNHTVIVENKTEVSFLNYNYDASISTNLPIPCINKVYYCEFKIFETDGPLNSDENVSKGVISFGLSTQPYPYFRLPGRHHHSIAYDSNGARRFNDSFKLNEQLRTLFPQCEKGDIVGIGYRSRSGTVFFTRNGKKLNEKSVGGHIRGWKFQYLYPIIGSNVPCQIHVNFGTYGFVYIEANVKKWGYAKSNGIKLPPPSYEDYGKDTLLESGGEDNDFDEDFSDGDSDNIAAGSTTNLNDDIIIRNGEILPPPPGFEFTMSPPTGKKIINEEINLDSLPMLPPSYSDDEHHSKNDKSAISGRIIGTSRNLITDEASFDSVDNDNEDENDHERDPEQFSEFDDYESRMHGI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MCSQPRFSASAVSGLSSVEVSRLKPKSQYLRNKVALVWKEGRSPGDRSPTWKKSPSDRDHPHQSFRTDAEELRKERVLFALPVTVVNHLAQREPDLVMSPHPEAVIDYVTVDTGPASSRCLSRTLLCISPEQQKMNISQASVSFKDVTVEFTQEEWQQMGPIQRTLYRDVMLENYKNLVLVGNCTYKPEVIFKLEQGEEPWFLEEEFSNQSLQVLGDCKGDNLFKRNKRIKEKPLQQVIFINNKPLTKEEEKFGGRPFNLHIASVSSTKMSCHCDSWRVNSQNSSQFILNNRTYSTKKRDSCSVCENLPFKIKFERTHAGEKCFEYNKNGKALSYKESLTEHQKCQTLEQAFEYDEIRKAFYNEAVSVTHKSTHTGEKSCKDDEFRENCDKTTLFDHKRTKTGKKHCRFNQCGKSFCEKSVVKEYNKFNVAVKHYECNTSGNTFIRKSHLTQPQRTVTEKNPLVCNGKTQTGDKSFEYCENKSYQTSTHRVCQRTHSEVKPYKCNECGKSFCQKGHLIQHQRTHTGEKPFECNECGKTFSQKSHLSTHQRIHTAEKPYKCNECGKTFVQKSTLRGHQRIHTGEKPYKCSECGKTFVQKSTLRDHHRIHTGEKSFQCNECGKTFGQKSNLRIHQRTHSGEKTYQCSECEKSFWRKDHLIQHQKTHTGEKPFKCNDCGKTFARTSTLRVHQRIHTGEKPFKCNECGKKFVRKAILSDHQRIHTGEKPFQCNKCGKTFGQKSNLRIHERTHSGEKSYERNEYGKLYKKSTLNVCQRIQGGGKPY
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit. Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability.
Subcellular Localization:
Nucleus.
Domain:
The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.
Sequence:
MGKKRTKGKTVLADDDSEILEPRCRHIKKGLEQSGLKKSLMNVQWNVCQECKIDNRTNDKPEGENKENPSIWLCLKCGHQGCGRYSQEQHALKHYTTPRSEPHCLVLSLYNWSVWCYLCDEEVQYSSSDRLGQLVDYIRKQINVKTSRQASKEQGKAEIENKKLEKDSKNEQEREKKENMTKENSPLNAAAHMTVKGLSNLGNTCFFNAVMQNLSQTLVLRELLKEVKMSGTIVKIESPDLSLTEPLEINLGPPGPLTSAMCQFLNEMHETKRGIVTPKELFSQVCKKAVRFKGFQQQDSQELLRYLLDGMRAEEIQRVSAGILTALGSPTGKPDEDLRRRIKEHERKKSMPSFVDRIFGGELTSTIMCEQCKTVSLVHESFLDLSLPVLDDQSGKNINDKNIKKTKEDESKDSEEEKDNNIYMKKNTIPPYTSKHWQKKAKKQAKKLAKNQRRQQKMQEKTIQLNNLCMNDKPEEHPHVTDALPEEETDDDSNSFSQEEEKCQESCSNQEDISDRESPVEALPGNAGEADLPRAAFSIERAGDFNGASLGGDSEDEEDLAGDLGHLQLDPLLEPDEGNGELLNDGCPVGAKIYEVVHDVPETAFCTLAPREAADTDEGSIHHCLYQFTSNEKLQGSNKLLCDVCTQRQRPGPKAHSKGEKKCVYTDAKKQMLISQAPPILTLHLKRFQQAGLNLCKVNKHIKFPDVIDLAPFCTIKCKNVAEGNTKVLYSLYGVVEHSGTMRWGHYTAYVKTRTSNSHLYNLVLDGTSPQEFENESTKGQWFHISDTHVQAVPASKVLNSQAYLLFYERILNN
The following text describes a protein:
Function:
Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Negatively regulates stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Also seems to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involved in seed mucilage production. Activates the transcription of GL2.
Subcellular Localization:
Nucleus. Note=Moves from developing hair cells (trichoblasts) to developing non-hair cells (atrichoblasts).
Sequence:
MATGENRTVPDNLKKQLAVSVRNIQWSYGIFWSVSASQPGVLEWGDGYYNGDIKTRKTIQAAEVKIDQLGLERSEQLRELYESLSLAESSASGSSQVTRRASAAALSPEDLTDTEWYYLVCMSFVFNIGEGIPGGALSNGEPIWLCNAETADSKVFTRSLLAKSASLQTVVCFPFLGGVLEIGTTEHIKEDMNVIQSVKTLFLEAPPYTTISTRSDYQEIFDPLSDDKYTPVFITEAFPTTSTSGFEQEPEDHDSFINDGGASQVQSWQFVGEEISNCIHQSLNSSDCVSQTFVGTTGRLACDPRKSRIQRLGQIQEQSNHVNMDDDVHYQGVISTIFKTTHQLILGPQFQNFDKRSSFTRWKRSSSVKTLGEKSQKMIKKILFEVPLMNKKEELLPDTPEETGNHALSEKKRREKLNERFMTLRSIIPSISKIDKVSILDDTIEYLQDLQKRVQELESCRESADTETRITMMKRKKPDDEEERASANCMNSKRKGSDVNVGEDEPADIGYAGLTDNLRISSLGNEVVIELRCAWREGILLEIMDVISDLNLDSHSVQSSTGDGLLCLTVNCKHKGTKIATTGMIQEALQRVAWIC
The following text describes a protein:
Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLRRQARLRREYLYRKELEDRARTIDEKKQRLKQALDENRLIPTEVRKEALKLQKLTEYDDEGAEGVNSHMDDEYKWAGVEDPKIMITTSRDPSSRLKMFAKEMKLIFPSAQRMNRGNHEVVTLVKACRANEVTDLVILHETRGQPDGMIVCHLPFGPTAYFTLYNVVMRHDIPDIGTMSEAFPHLIFHNFTSRLGKRVSDILKYLFPVPKDESRRVVTFSNQEDYISFRHHTYKKTDHRTIQHASRAGDRITLQPLYMIKLGTLENESTADVEWRLHPYTHTAKKRKFLSVE
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSVIDKYIGKLLETPSEEQRTIVQELSNTRSETKRAIYLGMLKNILELLNVRNKGYSIVFMNQLTTDLQRSEIYQTMPVSKSEILLLTNIVNDIGYRFNSEESLEKVVKAQSIIRGFLYHKRYLTYKAFSATKFQQYNSSFLNLHEKQIHYVENIETLIYYLDELRAQGKFKILGEYPYKNYYNSLTSILSLETQFKNGLNDIYGTFPKVSGVGEVVKKYCEGVLEAYKEINLQGAVVMATVFYEKENPYFKEVYETLSKGQTYAFRYLLQSFPRIQHFSNLIKLLTVMKEAVEKLSEYKEEIEPLEEALKELNNINIILHDTIKSEQMNNKEITIKTNETTEFSSLLLKIKKEFTKTPSVVEVYLKLGKEIGNIEEKRFLKETRVTVEILPNIDNYPPNLKTNTQSVSFGSSNHLTEKKHSTSLRPKLQKRTNRQKEEAKLKASGELMKDIEVLKNNDLETIKFEATLFIMNDIIYVSKMDSLEKYHILTEIPLTGNGFSVSNCIGNKFNIGSKVFDFTTSFIIPNEDDARNLFLLLREVFFVHSPPKLFGGSLEDILEREGNTTGVPLCIKALGEYLMNPNNLQTEGIFRKNGASNKVSRLAHVLDQMPDHFNSFNEYAVHDIAATFKKFFMDMSEPLFSPEVVDLFIKIVKGSPDEKDEIKKVMKEHMKPMYFKLADFLIHVIKKTVENENVTLMNVHAMSVCIGPAIIRSTNEIVVQPNSKNNDVEGAVTKVTRCNEILAEIISDCDFFFQ
The following text describes a protein:
Function:
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAATGVDKDRPRAMTSTTYLGLLLVGIQVLGFVAAIHAVLTVRTAQGAIAWATSLVFMPYLTLLPYLVFGRSRFDAYIEARRQANREMHLAAAELDWRPWVEEALAARQVSGYKGLKALVRMTRTPTLANNRVRLLVNGEASFEAMFKAISAARQVILVQFFIVRDDALGQRLQQLLLERAANGVEVFFLYDAIGSHALPHRYVERLRQGGVQMHGFSTGSGMLNRFQVNFRNHRKVVVVDGECGFVGGHNVGVEYLGEKPPLAPWRDTHMELRGPAVACLQESFAEDWYWATHSLPPLILPPQYDSEGALCQVVASGPADAQETCSLFFVEMINAAHERVWITSPYFVPDEAVMAALRLAVLRGVDVRLLIPSRPDHRTVYAASSLYALEAIRAGVKVFRYQPGFLHQKVVLVDRDTAAVGSANLDNRSFRLNFEVMVVTVDEGFAGEVEAMLEADFAESLEFTPEDRRSVRRLQQLGMRVARLVSPIL
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVIASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRMNKEIKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKLKVSA
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to pentanol, ethyl acetate, and propyl acetate.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKSTFKEERIKDDSKRRDLFVFVRQTMCIAAMYPFGYYVNGSGVLAVLVRFCDLTYELFNYFVSVHIAGLYICTIYINYGQGDLDFFVNCLIQTIIYLWTIAMKLYFRRFRPGLLNTILSNINDEYETRSAVGFSFVTMAGSYRMSKLWIKTYVYCCYIGTIFWLALPIAYRDRSLPLACWYPFDYTQPGVYEVVFLLQAMGQIQVAASFASSSGLHMVLCVLISGQYDVLFCSLKNVLASSYVLMGANMTELNQLQAEQSAADVEPGQYAYSVEEETPLQELLKVGSSMDFSSAFRLSFVRCIQHHRYIVAALKKIESFYSPIWFVKIGEVTFLMCLVAFVSTKSTAANSFMRMVSLGQYLLLVLYELFIICYFADIVFQNSQRCGEALWRSPWQRHLKDVRSDYMFFMLNSRRQFQLTAGKISNLNVDRFRGTITTAFSFLTLLQKMDARE
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQLVPFYWMNLLTTGIAAVSILLYLSATIILPNVLRLLVARAIIVRV