lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus.
Sequence:
MPPRSRTATSDAYHGSFDPGVTGRRTGVAPPTKVRRTSNGIEAFSDYFNSPRKDPSVSPIRSPSKRTNDDQIPQRMRNDRPDMFHEIGERGRKTGISPPKNSTRDENGFEDFDNYLIKATEQTNKGIARERRKSMRRKSTGQALHNRKLSVATFVDDDDDDDEFMEESMSLATPDTSALQRRQSRSSHLGSAQSNPIDSDQRKTRSRISDAIDQSIRTPTGSDLIDFDVVPEGPVHSHSRHKSHDEQPMTIQDDEQEQDEDEDDIQNSGGMVANEYDEESVVSGELDAPPPPPDSVEDEESDNPAGLEDIAEVEEEEEDHETTAGPNDHADSSNPKPPERPKPQKKNHRPPPPAGVRRGQRQRFERLAHWRGERVVYGRSVTPDGNQKVIGMVDVVRVPTEPPESFAASRRNRRGMTKIKSESVAPQEIHDNRQPEEGWDSKTLPNGIVYSSTKHKDIERAVVCTKNMVTIDVEGKAGVPNSFEFQRVFKHSDFIAGGFMYIPVGGGKPLKPSKDNCYFFTVVEGAVSVHVHRTTFVVAPHGVFWIPRGNVYSIQNISERTAKLSFAQARRATDADAEIDSDDIDEEHSMLQNSSNDPSTSTSIPQKAGRLPHPDESLTHDPTNKSTKTRKNLNKNKKKVVNENDTSASTNTSNPPGKKKPRKVLGMKKKKKNMKQKQKQKEQPDEEEPDEEQQQEEEREEEGEEEEEEEAQSS
The following text describes a protein:
Function:
mRNA endonuclease involved in the No-Go Decay (NGD) pathway, which catalyzes mRNA cleavage and degradation in response to ribosome collisions. Acts downstream of the ribosome collision sensor HEL2. Specifically recognizes and binds RPS7/eS7 polyubiquitinated by MOT2/NOT4 and HEL2, promoting CUE2 recruitment to stalled ribosomes, where it mediates mRNA cleavage upstream of the colliding ribosome. Also mediates mRNA cleavage within colliding ribosomes: recruited to colliding ribosomes downstream of the RQT (ribosome quality control trigger) complex following disassembly of stalled ribosomes and cleaves mRNAs partially released from the colliding ribosome.
Domain:
The CUE domains specifically bind RPS7/eS7 polyubiquitinated by MOT2/NOT4 and HEL2.
Sequence:
MSMDNNDDHESKLSILMDMFPAISKSKLQVHLLENNNDLDLTIGLLLKENDDKSTVDNELHQLYDMFPQLDCSVIKDQFVINEKSVESTISDLLNYETLQKLKDNQANSPDSVKRNEKKNNWESTNDHIESIIKFTDAPKNIAQEYLAENGFDTVKAIIKIILDYYDKRDFKKDVDTFKVKRSPNTTVRGGRVQSSTGLAHVLKKGKESANVAQESLKRPRSYKHSLDSPQMVELNELVADNRDLKAINHEFLQKCLQFYDGDVVKVLNISSLLIEDDKNITKTWNFDEGFTLTSRDNCKQHLPKFSTPQISRRNEVGNTYKLPLHDKETPEGAVPVINNLFQTYRLDFHGFLPSEAVSTLKLALNKWWSKEVAERELNSHNINSYGSKVQFVSPLIVVTGRGIHSIGGISKVRLQVKSFLEKNHYIFWEESSYFRIEGKKKK
The following text describes a protein:
Function:
Catalytic subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase. Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAAAVGPGRSTSSYSEVQHNRLIVSLPLPSVLKKPFSVIDGPPSSAAGNPGEIAKLFPNLFGQPSVSLLPGHTSGAALDHTLKVGVVLSGGQAPGGHNVISGIFGECFSNSSYLMEKTKNSTLYGFKGGPAGIMNCKYVELTADFVYPYRNQGGFDMICSGRDKIESDEQFNQAAETAKKLNLDGIVVIGGDDSNTNACLLAENFRGKGLKTRVIGCPKTIDGDLKCKEVPTSFGFDTACKVIPVCGMYRYRLSKFTIPVQIYAEMIGNVMIDARSTGKYYHFVRLMGRAASHITLECALQTHPNITIIGEEVAAQKQTLKSVTDYIVGVICKRAKLGYNYGVILIPEGLIDFIPEVQQLIAELNEILAHDVIDAAGSWKKKLQSQSRDLFELLPQAIQEQLLLERDPHGNVQVAKIETEKMLIQMVEAELESKRKEGSYTKQFKGQSHFFGYEGRCGLPSNFDSNYCYALGYGAGALLQSGKTGLISSVGVGNLKAPVEDWTVGGTALTSLMDVERRHGKFKPVIKKAMVELEGAPFKKFASLREEWALKNRYFSPGLSWSVDEKSLSDAFSSFGQVTEVRIMYDKETGRSRGFGFVYFLKDEEASSAKDSMDGKAFLGRPLRVSFALEKVRGAPVVVPRLTSTGNAYRKTR
The following text describes a protein:
Function:
Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules (By similarity). Required for neurovascular modeling of the hindbrain. Acts in a non-cell autonomous manner and is required for migration and proliferation of central artery endothelial cells. Required for normal courting behavior and spawning.
Subcellular Localization:
Secreted.
Sequence:
MMLSLPKLSAGGVVVLLATLLHTLTVQGASVRHHRLRGGDQGGFLAPSSDMIKALEYIESLKQRADGPESPTGDYDEVDKFRFLVQLASLQDENTPTHEDATRWPDNKVPQWVRSLLRVLDQAGESPESQAAGNERRLHKTRRPVADGESPAGDYAGFVKPHKKYPLMFEDEENGRDNKRATEDLDEQYTPQSLANMRSIFEELGKLSAAQKRDDEEDGEDDDDLYRVRNAAYEDVTGGEEWVPLEEQLETEELVKGSHEEYKRALGDISEQGMENMERRGEEEDENPDDDTKLVDYYLLKVLEMTDQAQKRDLMEGRRRLLSRPSLIDPRAIKQLLSAISMKLQVPPEDLVGMLFMEETRKQQQRLPEPQLARNPSQPRYKSRVIKYYNGRQPEVTVSDIPHDVKTEDILKVLGLGNLANKNAKFSLLKQRPYKTAMTNYFNPNGRRGSLFLSELNKAPSKRKDDYDDDDAVDEDEESTFLAAKLLTEYPDTSSSNRKRAIDSAANGQLPYELYEEAMKDFFDQVDNGKSALAKRDTQGKEEPEGPQKPPAQDPAQETVDQTPPESGTEDGKEYHGKIVAGM
The following text describes a protein:
Function:
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and by beta-adrenergic receptors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Sequence:
MASSPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNTHPKHCKYSISSSCSSSGDSGGLPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSMNLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAVHMKSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVWTPLSGRVDSSNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVLFETFGYHFRNEDCYPSPGPGALHWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVIERLGQSVVADQLKGLKTYLISGQRAKESHCSCAEALLSGFEVIDDSRESSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGTVQNGCQDEPKTSTKASGGPNSKTQNGLLSPPAEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITCFLKYGATATPPPPAALAVFGADLLLEVLSLIVSIRMVFFLEDVMTCTKWLLEWIAGWLPRHCIGAILVSLPALAVYSHITSEFETNIHVTMFTGSAVLVAVVHYCNFCQLSSWMRSSLATIVGAGLLLLLHISLCQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDNGVVPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYSDKASLGSDDSTQAKEARLSSKRSWREPVKAEERFPFGKAIEKDSCEDIGVEEASELSKLNVSKSV
The following text describes a protein:
Function:
Transcription factor required for phloem identity. Has a dual role both in promoting phloem differentiation and in repressing xylem differentiation during vascular development. Regulates the expression of the transcription factor NAC045 (AC A4VCM0). May activate the transcription of specific genes involved in phosphate uptake or assimilation. Promotes flowering through transcriptional activation of both FT and its transport machinery component, FTIP1.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Nucleus.
Sequence:
MFHAKKPSSMNGSYENRAMCVQGDSGLVLTTDPKPRLRWTVELHERFVDAVAQLGGPDKATPKTIMRVMGVKGLTLYHLKSHLQKFRLGKQPHKEYGDHSTKEGSRASAMDIQRNVASSSGMMSRNMNEMQMEVQRRLHEQLEVQRHLQLRIEAQGKYMQSILERACQTLAGENMAAATAAAAVGGGYKGNLGSSSLSAAVGPPPHPLSFPPFQDLNIYGNTTDQVLDHHNFHHQNIENHFTGNNAADTNIYLGKKRPNPNFGNDVRKGLLMWSDQDHDLSANQSIDDEHRIQIQMATHVSTDLDSLSEIYERKSGLSGDEGNNGGKLLERPSPRRSPLSPMMNPNGGLIQGRNSPFG
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLHPIVKWLSFTTCIPYLLIVNWKSQNPLLYCFALHISLTLLSHIQLINMASCFPNASPFLVMLAMCLLISTSEAEKYVVGGSEKSWKFPLSKPDSLSHWANSHRFKIGDTLIFKYEKRTESVHEVNETDYEGCNTVGKYHIVFNGGNTKVMLTKPGFRHFISGNQSHCQMGLKLAVLVISSNKTKKNLLSPSPSPSPPPSSLLSPSPSPLPNNQGVTSSSGAGFIGVMMWLMLLL
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of dre2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Sequence:
MSGSQSSGSPGSPGPPGPPGRSALVVYGSETGNAQDVAEEVGALAERLHFTTQISELNHVKPESLRSYTIVVFAVSTTGQGDLPANARTFWRSLLLKKLPPTFLSGVRFTWFGLGDSSYPKFNWAARKLYKRLLQLGADEIYPGGEADHQHSSGLEGTFIPWLAGFRKHLLDKYPLPPGQDPIPDDVQLPPKWVLRLRDQEAASEDVSPPDAMGAAVTGDFPDSYRLDNDHRPLHDSLTATLVQNKRVTPQTHWQDVRHLILTVSDPISYAPGDVLTITPKNTAEDVQSLIEMMGWQEQADQLVSLVPRDSTRSTNELPSPPIHSLDSYPRLTLRELLINYLDIRAIPRRSFFAAIAHYTTYEMHKERLLEFTNPEYLDEFWDYTTRPRRSILEILHEFDTVKIPWQHATSTFPIIRARQFSIASGGELKRTSVGGARFELLIAIVKYRTVIKKIREGVCTKYISNLRPGSTLKIQLQRGGLNSSVGQLVGPTMLIGPGTGVAPLRSMLWEKAAIVKSYQEKNPGVDPPIEPTILVYGGRNRAADFFFEDEWQQLSDLIKLKVLTAFSRDQKQKVYVQDVIRENSSLVFNLLHDKGGAVFVCGSSGRMPQAVRETLTEAFQYGNDAGTQPFSRREAEDYLVGMEKTGRYKQETW
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MLAKIVVSGISLILVVGVVIGVVVAVNRSNDSSENTEDLSPQMKAVTQICQPTNYKETCTKVLGSANSTDPKELIKAGILAISDSVTKSMNLSEDLVVNGGSNEPRTKLALEDCKILLKNASDELNDILAKVGENDLKSIAEQADDFRIWLSSIISYQELCIDGFDHDSNLKYSVHNSTDYGSELTDNVLTILGGISKILENFGLHLNLPSTNSRRLLRADGYPTWVSAADRKLLAAGNAGKPAPDAVVALDGSGQFKSINAAINSYPKGHQGRFVIYVKAGIYNELVKVPKRQPNIFMYGDGPRRSIITGKKSFTSGFNTWNTASFVVESPGFICKGMGFQNTAGPDGHQAVAMRANSDMSIYHNCRFDGYQDTLLYQAGRQFYRNCVISGTIDFLFGYGAAVIQNSLIIVRKPNPNQSNTVTADGKKERGQPTGLVIHNCRIVPEVKLDPERLTVKTYLGRPWKQFSTTVVMESQVGDLIQPEGWIPWDGNLFLDTLFYAEYANSGPGANTARRVKWKTLHFLNRIEAQKYTLGTFLAGSGQWVRAAGVPFLLGLRR
The following text describes a protein:
Function:
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPVEAYGRVKSSILEHHKWFDSSLPMIASENVTSPAVRKAMTSDFGHRYAEGWVGERVYAGTKYIDEVESIAMELVKRLFNVKFADVRPISGVVANLAVYTAFTNPGDVAMALPITKGGHISMGPLRGSEGQFIGGTAGAVRGLDVKYLAFDDHNMNVDVDKSIKRIEENKPKLVILGGSVILFPHPVKELSDVCKSVGALLHYDAAHVAGLIAGKQFQQPMEEGADVMTMSTHKTFFGPQHGAVITNDEEKFERIKLANFPGLLSNHHLHSVAALALAAAEMLAFGEEYARAVVRNAKALAQALHDEGFSVVAEHLGFTQSHQVLLDVDALGGGHRCEKLLEEANIIVNRNLLPWDIKRGRSFKDPGGLRLGVSELTRLGMGEEEMKEIAKLYRKVLLDREDPKKVAGEVSELRKRFRNVKYAFEEGPAYEY
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MSAGPNDTFPVSEKTSGASMSYGATAPPGYDNPNYIYQTLPSSAAQHTRVGQQAFVESDRLIEMHRAQHSLEDDKEDMDIYSTKGHVKVTFDEIFNEPKNVTSFEPIRTVNSVVFEYTQGGVYKILSAGLGVILAVVWGLAFGLFNFFIVWFVHPWLKMCFMGIRLFGLTIKAIVRTCIDPFFQSLGLSLSTIAGRFSLKLSGIPGPRADPENAIQNNQ
The following text describes a protein:
Function:
Salivary chemokine-binding protein which binds to host chemokines CCL2, CCL3, CCL4, CCL8 and CCL18.
Subcellular Localization:
Secreted.
Sequence:
MARNWSFRVIFVSAMWCALLKFATLEEPKDGYDYTEGCPFVVLGNGTHAKPAGCSHLCNGAPETLDDNMECYNVTEEVAKRMTPDIPYTCWLGWCSKGECKRDNRTEVCYRGSERE
The following text describes a protein:
Function:
Antitoxin component of a type V toxin-antitoxin (TA) system. Neutralizes the toxic effects of toxin GhoT by digesting ghoT transcripts in a sequence-specific manner. In concert with GhoT is involved in reducing cell growth during antibacterial stress. Overexpression leads to transcript level reduction of 20 other mRNAs involved in purine or pyrimidine synthesis and transport. Not seen to bind its own promoter DNA.
Miscellaneous:
MISCELLANEOUS: Has a similar 3D-structure to Cas2 proteins; MISCELLANEOUS: Can be modified to become a classic type II TA toxin (called ArT) which causes cells to become ghost-like, probably by broadening substrate RNA recognition; the toxic activity is independent of ghoT and mqsRA. Antitoxins to this evolved ArT toxin have been artificially evolved from antitoxins mqsA (a type II TA system) and toxI (a type I TA system).
Sequence:
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDIDFDLNIMTVDDYFRQFYK
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
MESSSVVPPKRREKSGGDYVKRPLNAFMVWSRVRRAKLREEMPDLRNTEISRRLGAEWREMSAEQKLPHIQRSRQLRIEHFDMYPNYRYRPKRKLKPGPVTGPRPVADILQASRSQAPPPPPPPSSLGLGYRPVTPVHTPPPGPPNACVSRVSGVPIPSALFCNFPYGYTRPSQQVFTSTACSSTRVCPTHNKPTMYPYSYSLHPRPYPHPYHRPLTLTLPSGSGTLHYIPTSLPEVDQDTVTSLPGSTRGRSTSLPVTTPTPQFLTSASYFATERPIITVPHYSLPPMTSLMHRSTNEASGSSPCVSAPSDPVLKCRPLQSLVSPDHSPSVQLLCTETDDDSDTETCSSPEEQGGSCHDNRRLQNLRSCTGLFWATPLAPGGGRAKEKVIVETVPAIEPVSIAGIEEPRGSQFRFEWN
The following text describes a protein:
Function:
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MASVLRGVFKTHLPRTLTRPKCARTFQTTTFLRNEQVKLPQTYDEEKVIIDEINKSLKPDDLQASTRLRNIGISAHIDSGKTTFTERVLFYTGRIKAIHEVRGKDSVGAKMDHMDLEREKGITIQSAATYCSWDKDDKSYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVAGVQSQTVTVDRQMRRYNVPRVTFINKMDRMGANPWRAIEQINAKLKIPAAAIQVPIGAEENLQGVVNIIDRVALYNEGEQGETIRKAEVPEDLKELVEEKRALLIETLADVDEEMADIYLEGEEPTVEQIKGAIRRATIGRKFTPVLMGSALANRGIQPVLDSVVDYLPQPNEVLNTGLELQKDNSEKPVHLTPSTSEPFVGLAFKLEEGPYGQLTYIRVYQGKLKKGAYMTHVKTGKKVKVSRLVRMHSNDMEDVAEVGAGEICATFGIDCASGDTFIGQGTQQQITMSSMFVPEAVISLSISPKTKDNGAFSKAMNRFQKEDPTFRVHYDSESKETIISGMGELHLEIYVERIKREYGVDCVTGKPQVSYREAITVPSAFDYTHKKQSGGAGQYGRVIGEMNPIESENKFETQIIGGKIPEKFLFACSKGFEDCLEKGPLIGHRVLGVHMLINDGQTHVVDSSELAFRTATHGAFKQAFLNAQPVILEPIMSVEVTAPNEFQGSVVGLINKLGGMINDTVNGPDDFTVTAECSLNSMFGFSTSLRASTQGKGEFSLEFLKYSPTAPQVQKQLIQEYQKAQAAKK
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). The Cas4 region acts as a ssDNA exonuclease, while the Cas1 region acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
Sequence:
MAETDGSIPLIPVRMLNEHVYCPRLAYLMWVQGEFSHNEFTVDGVIRHRRVDAGGGVLPSETQEDSRIHARSVSLSSERLGITAKIDLVEGEGAYVSPVDYKRGKRPHVAGGAYEPERVQLCAQGLLLREHGFASDGGALYFVASRERVPVAFDDELIGRTLAAIDEMGRTALSGTMPPPLEDSPKCPRCSLVGICLPDEVRFLSHLSVEPRPIIPADGRGLPLYVQSPKAYVRKDGDCLVIEEERVRVAEARLGETSQVALFGNATLTTAALHECLRREIPVTWLSYGGWFMGHTVSTGHRNVETRTYQYQRSFDPETCLNLARRWIVAKIANCRTLLRRNWRGEGDEAKAPPGLLMSLQDDMRHAMRAPSLEVLLGIEGASAGRYFQHFSRMLRGGDGEGMGFDFTTRNRRPPKDPVNALLSFAYAMLTREWTVALAAVGLDPYRGFYHQPRFGRPALALDMMEPFRPLIADSTVLMAINNGEIRTGDFVRSAGGCNLTDSARKRFIAGFERRMEQEVTHPIFKYTISYRRLLEVQARLLTRYLSGEIPAYPNFVTR
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSKLKEIQRQSTVSWSPIADYPDYMAVGTVAGTISADFDTTSKLEIYSLDITNNESKQMALKGVTSANTRFNKVVWGQSSSNFPNGIIAGAMDNGNINLYNPTKILENSDDALIGIGQKHTGPVQSIDFNCQNPNLLASGGSDSEVYIWDLNDATQPSAHTPGSKSQQSSDITCVAWNKKVPHILGSSSYNGYIVISDLKSKKTLMTFNDRNRRCKYRTIVWHPNEATQIVAASEDDDYPIVQSWDLRNTSTPFKSFEGHKKGVWGLSWSPNDPALLLSCGKDNRTICWNYDRQEVLCDIDHQSNSNGNEWNFEVQWSPRVPALLATSSFVGKVNVYSLQDVNEKNVAPQINSLGLQEPTTQPTYKHTPNWLLRPCGASFGFGGKLAVFGKPSKKLGASSPQTSPQASVERQSRIVHISHVTTEKEIVKSSEELERVISTGQYEQYCEEKIQQSTNEEEKSIWSFLKVKFAQDDRFKILDYLGYDIETIKKELSQFLGTLPELPIEKKEPTSTTTTTTEGSTPDESNDNSGDQSSLFPNTGDDDFAKNIANGLTLNGDDSSSVTSTESKTPIEFPVDEKEQMITKALLVGDHQAAVDCCLRLGRYSDALILAHSAGQEIWKKTQEAYFEIVKSPFGRVVSCIVKRDFNRLVRTADLSDWKASLAILCTYAAPSDFKNLSGILGDRLINETKDTKSAILCYICAGDIDKTVNIWTHRSNTNESKETIEESHQDLQNLIEKVSIFRSACGNNNSSLNVVLSMKYAKYAEILASQGNLSGSLRYLSHINNPECQQACGVLYDRVYRATSNHQGIRPPPFPFQLCEVRPSNKPQQPQQQPQQQQPQQQELFGQFNSNAKRAPNMQPLFTNQQQQQPPHMMPMNQQQQQIPSQPQPSLFKTMGNQPPMMMNQGPTTNFNQPPTNFNQPPPMMMNQGPPPTGGFNQPPQNLSKPPSFNQPPPMMNQGPPPTNFNQPPPMMMNQGPPPTGGFNQPPPMINQGPPPTNNFNQPPPMMNQGPPTNIFNQPPPSNQISPPPQMNQGPPMIPSPMGNTNQPPMMPMIPNPTQPPQQLSPPPIMSSNATPSSVRSPILEKSNAPGSPNEFSVAPKPNVHNKTPSISAEGSPVQEPTTEEINSFIERLTQSIQSLNGKSDSKVWDDVNKRCQTLINKVSKKDISGGAFRALEHILSSIVERDFKKASDTYIQITSTGYWAEIGSQPMVGLKRLIDLGLKQN
The following text describes a protein:
Function:
Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.
Subcellular Localization:
Cell surface. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MEPLLHVFIIVAVCAAHACGFTQQGDVRSDTGPLPAPRPAAGSRPPSEAAASGSHTATRSAEQETPPAAGHPPVSSQSPVPPLSSAGATLSPRPAAPLTGDYTVTDSKHQVCIKARLGAQFMVKKNKKTAYFNISPTSTQAQGQCGQSTAWLLLSFSEGFVNFTFVKEGSISYVDEIRASLHPTATCVSCTIPGEEYTGKIVNVKLFKTADGHAYTCNSQYEVFLAENLSLRIVNTQMQAFNITNGRFGQEEECSADWKRRTIPIILVATVVGLSLIVILSCLIIREHDRGRYERI
The following text describes a protein:
Function:
FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Sequence:
MATKKTPVTDDAALPSFEDGVDLDQAIGDLRGVLKTDAEGSLSDFGDFGDFGSTDEVSTDNDLSAFGGGAADFAMDDFAAAPQVAGVKAPLGSGLSENMEMIMDIPIDVQIVLGTSRMLVSGLMSLEEGATIALDRKIGEPVEIMVNGRRIARGEITVLEDDDTRFGVKLIEVLSTRKA
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MHQTEAFAAGEEAEELRPSVESDKKEERILARRLRLAARKEAQTKQRLGEDDLGKEDVKEETRKSQKEVEHRERRMAKLKSDGLELVTNIQVAADARESDRRTELEEGHRLRREKLENEAKSSQEKFEEINRKWTDAKMKQTPLDLRDALSSQQQLCEQIIADKNKLISELQQELKASDDRYVKDLKRQAKDIDLLVERMEEQISTLKKSYREDLHQIENSLDEERRTLLTKHKKKWEHERKDRNEKELKNMMQSLSVMEEYADLLQKLRVQTAEEYNIDKIRMDTEVQKLRMKVQQTKFNCHMNEEKLDYKYEVLKKKEEENAIIKSQLKRKIIRMQDVLNNLKSKLTKQEKQSKAGNQSLSNDYTRISQQYKDMQKKARHFAALDAERLEKLWLMCEDEAKALTHRALETDRVIHEQQLGLEWASPPLPFMERSGAVQQKTFRTATQAAADTLKGEPEGGLDEDTAAGLNKRTVKSILELLCDEMGFLVESKLLMLLSPLEKNEQSLIKLDAIFSAIGIESEKDVYKMAEFFMNYRQHESKYTKDETANGQGESAEELSNLIHTEDLLAALKDFTAQFCRQDVHASHKSSILGLDMRDDSEDAAYWESIANVMPESKLKLWDALDTALNKYHAVLTERTELLMETQNIQQQNSELRQLLHLYTTSKAQ
The following text describes a protein:
Function:
Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has replication fork regression activity, unwinds stalled or blocked replication forks to make a HJ that can be resolved. Has a DNA unwinding activity characteristic of a DNA helicase with 3'-5' polarity (By similarity).
Domain:
The wedge domain within the N-terminus inserts into the replication fork junction, where the lagging and leading strand split (By similarity).
Sequence:
MAKVNLIESPYSLLQLKGIGPKKIEVLQQLNIHTVEDLVLYLPTRYEDNTVIDLNQAEDQSNVTIEGQVYTAPVVAFFGRNKSKLTVHLMVNNIAVKCIFFNQPYLKKKIELNQTITVKGKWNRVKQEITGNRVFFNSQGTQTQENADVQLEPVYRIKEGIKQKQIRDQIRQALNDVTIHEWLTDELREKYKLETLDFTLNTLHHPKSKEDLLRARRTYAFTELFLFELRMQWLNRLEKSSDEAIEIDYDIDQVKSFIDRLPFELTEAQKSSVNEIFRDLKAPIRMHRLLQGDVGSGKTVVAAICMYALKTAGYQSALMVPTEILAEQHAESLMALFGDSMNVALLTGSVKGKKRKILLEQLENGTIDCLIGTHALIQDDVIFHNVGLVITDEQHRFGVNQRQLLREKGAMTNVLFMTATPIPRTLAISVFGEMDVSSIKQLPKGRKPIITTWAKHEQYDKVLMQMTSELKKGRQAYVICPLIESSEHLEDVQNVVALYESLQQYYGVSRVGLLHGKLSADEKDEVMQKFSNHEINVLVSTTVVEVGVNVPNATFMMIYDADRFGLSTLHQLRGRVGRSDQQSYCVLIASPKTETGIERMTIMTQTTDGFELSERDLEMRGPGDFFGVKQSGLPDFLVANLVEDYRMLEVARDEAAELIQSGVFFENTYQHLRHFVEENLLHRSFD
The following text describes a protein:
Function:
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes.
Sequence:
MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHRAGEIWHISASPADKGVLATCYNKTADSKVLTCAAVWRMPAELEPGGHESPEDAASPAHALELLCHLDHPARGSTACVAWEPAGDGKRVISLADNHLLLWDLQESSSQALLASSASLEGKGQLKFTTGRWSPHHSCTQVATANDTAVRGWDTRTMSQIYCIENAHGQLVRDLDFNPNKQYCLASCGDDCRVKFWDTRKVTEPVRTLEEHSHWVWNVRYNHSHDQLVLTASSDSRVILSNMASISSEPFGHLVDDDDLSDQEERRPEEKSQEPPQDSVIATYEEHEDSVYAVEWAAADPWLFASLSYDGRLVVNRVPRALKYRILL