lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box (5'-GGA[TG]GA-3'). Displays weak ATPase activity, but this activity is not required for promoter binding.
Miscellaneous:
MISCELLANEOUS: A study on malT mutants has shown that some of them became nearly completely resistant to Aes repression while still being sensitive to MalY. These mutations are located at positions 38, 220, 243, and 359, most likely defining the interaction patch with Aes on the three-dimensional structure of MalT.
Domain:
Consists of four structural domains: the ATP binding site resides in domain I (DT1); DT3 binds the positive effector maltotriose with a low affinity, and the binding affinity is increased in the presence of DT2; the C-terminal domain DT4 contains the helix-turn-helix DNA binding motif. DT1 also contains the region that interacts with MalY (but not with MalK), and the binding site for Aes is also likely to be contained in the N-terminal portion of MalT encompassing DT1 and DT2. Domain DT3 may mediate oligomerization.
Sequence:
MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALITSPAGYGKTTLISQWAAGKNDIGWYSLDEGDNQQERFASYLIAAVQQATNGHCAICETMAQKRQYASLTSLFAQLFIELAEWHSPLYLVIDDYHLITNPVIHESMRFFIRHQPENLTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFTHQEAKQFFDCRLSSPIEAAESSRICDDVSGWATALQLIALSARQNTHSAHKSARRLAGINASHLSDYLVDEVLDNVDLATRHFLLKSAILRSMNDALITRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFCYHPLFGNFLRQRCQWELAAELPEIHRAAAESWMAQGFPSEAIHHALAAGDALMLRDILLNHAWSLFNHSELSLLEESLKALPWDSLLENPQLVLLQAWLMQSQHRYGEVNTLLARAEHEIKDIREDTMHAEFNALRAQVAINDGNPDEAERLAKLALEELPPGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMARQHDVWHYALWSLIQQSEILFAQGFLQTAWETQEKAFQLINEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIEVLSSYQPQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLGNGKYHSDWISNANKVRVIYWQMTGDKAAAANWLRHTAKPEFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQAGRKSDAQRVLLDALKLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPELEQHRAQRILREINQHHRHKFAHFDENFVERLLNHPEVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELEVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYGV
The following text describes a protein:
Function:
Recognizes fungal (e.g. B.cinerea and A.niger) endopolygalacturonases (PGs, e.g. BcPG3, BcPG2, BcPG4, BcPG6 and AnPGB) and acts as a microbe-associated molecular pattern (MAMP) receptor to mediate defense response against fungi (e.g. B.cinerea) and oomycetes (e.g. H.arabidopsidis). Functionality seems to depend on the presence of the receptor kinase SOBIR1 as an adapter protein.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSKSLLRLTFLLLLLLSCVSPSSFFTFNNPAEGPGACGPHQIQAFTQFKNEFDTRACNHSDPWNGVWCDNSTGAVTMLQLRACLSGTLKPNSSLFQFHHLRSLLLPHNNFTSSSISSKFGMLNNLEVLSLSSSGFLAQVPFSFSNLSMLSALDLSKNELTGSLSFVRNLRKLRVLDVSYNHFSGILNPNSSLFELHHLIYLNLRYNNFTSSSLPYEFGNLNKLEVLDVSSNSFFGQVPPTISNLTQLTELYLPLNDFTGSLPLVQNLTKLSILHLFGNHFSGTIPSSLFTMPFLSSIYLNKNNLSGSIEVPNSSSSSRLEHLYLGKNHLGKILEPIAKLVNLKELDLSFLNTSHPIDLSLFSSLKSLLLLDLSGDWISKASLTLDSYIPSTLEVLRLEHCDISEFPNVFKTLHNLEYIALSNNRISGKFPEWLWSLPRLSSVFITDNLLTGFEGSSEVLVNSSVQILSLDTNSLEGALPHLPLSINYFSAIDNRFGGDIPLSICNRSSLDVLDLSYNNFSGQIPPCLSNLLYLKLRKNNLEGSIPDKYYVDTPLRSFDVGYNRLTGKLPRSLINCSALQFLSVDHNGIKDTFPFYLKALPKLQVLLLSSNEFYGPLSPPNQGPLGFPELRILEIAGNKLTGSLPPDFFVNWKASSHTMNEDLGLYMVYSKVIFGNYHLTYYETIDLRYKGLSMEQENVLTSSATIDLSGNRLEGEIPESLGLLKALIALNLSNNAFTGHIPLSLANLKKIESLDLSSNQLSGTIPNGLGTLSFLAYMNVSHNQLNGEIPQGTQITGQPKSSFEGNAGLCGFPLQESCFGTNAPPAQKPKEEEEAEEDEQELNWKAVAIGYGVGVLLGLAIAQLIASYKPEWLVCLVKSRNPLRSFFGFEY
The following text describes a protein:
Function:
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLSHPLCLTQTARASAEVGQPCGSDQSLWTAAWGQDRPELHPITIAWSKSFATIVPALENGPDCHHTLSHSGGISGCSSHTSSCQAKAGRPGFKFASSMGEFNFANYYDEEFSNYSYNTDLPYILPDSAPCRPETLEMNTYALVVIYALVFLLSLLGNSLVMLVVLYTRVSRSVTDVYLLNLAIADLLFALTLPIWAASKAKGWTFGTVLCKLVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHWVKFICLGIWILSFILALPVFLFRKAIYPPYSGPVCYEDMGANTTKWRMVMRVLPQTFGFLVPLLVMLFCYGLTLRTLFQAHMGQKHRAMRVIFAVVLVFLLCWLPYNLVLVSDTLMRLQVIQETCVRRNDINRALDATEILGFFHSCLNPLIYAFIGQKFRHGLLRIMAIHGLVSKEFLAKDSRPSFVGSSSGNTSITL
The following text describes a protein:
Function:
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Subcellular Localization:
Golgi apparatus lumen. Secreted.
Sequence:
MMLNTVIFGWFLVNVVVMASHPHLRRRENSFILTSDTDSLPEMEHLEINSAEEKILEDLEAYDEDLGKAVHLQRRGTRSPSRCIPHQQSCLGHHLPCCNPCDTCYCRFFKAFCYCRSMDNTCKNEYA
The following text describes a protein:
Function:
Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MAFTMLRPMAARVLYPDIGMLSEDEENRSESDTSDQSYGCCEGAEARRKVPRKTGPMVMVKQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLGEGCEDGQPCFSAIYGAKGDLDGRQPRSICTFCLSNQRKGGGRRDLGGNCLKVRGVTPLRVARR
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFLRYFLDENQQRVYTLKRTAPSGEQTLTAHPARFSPEDKNSKYRIIIKKRFGLLPTQKAKTVC
The following text describes a protein:
Function:
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus.
Sequence:
MADKKLIVVFGATGAQGGSVAKALLEDGTFRVRVVTRNPRKKRAKELQRQGAEVVQGDQDDERTMEQALTGAHATFIVTNYWENLSQEQEIKQGKLLADLSKRLGLRYVVYSGLENVKKLTGGKLEVGHFDGKGEVEEYFRGLGVPMTSVRLPCYFENLLTYFLPKKASDGSGYLLNLPLADIPMDGLGISDLGPVVLSLLKSPGEYVGQDIGLSTCKHTVEEYASLLSKHTGKAVRDAKMTPEEYESLGFPGAKELANMFRFYALKPDRNMELTLKLNPKAKTLDQWLEENKEAFANL
The following text describes a protein:
Function:
Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway (By similarity).
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization of ATG20 to the perivacuolar punctate structures.
Sequence:
MAQDDSYEEKPEVISSDSGGSGYSTEIQIVGTVTSSDGSYVEYEIVHQKRSVWRRYSDFESLVKLMRRQYPAAIVPPIPGKQSLLSYAKHPRKAKSDAEFLNFRSRMLELFLRQCLLHPCIRSNPIFDKFIHSTVSWHVTLSSLDLPKDSNTDPLRLPPIATEHDPFAHLRSSMPLVMANSLSPPSSRALKPIHSLSNPSTASSLEPSSPLGSEDECHPPTSDMQPTHELNESPSTPTAPDFPHYNSSPSELSPTQRRSSISNGKDAPSPVLKDLTSYTQEVIVCRKFLHHSLSPSIHSTLSSISKMESCLSKLGSAFHSLTALNEIQLANHLQVIANAFEFSGMYAKEFEQEFNSSVYEKMVQSMQLAKCAADALKYKQLKIQQRDFLQDQLIHSNTMSATDSMVAASPTIHPATRLNTIQRAVVSQAKKGYTIFGRLQNVLHDFVEGETSISKESLQQHKNTIENQLAAANWDCQKIDEFMDAELKFYKECQTSQWEEIIKSVHECIYKWAQTNLQRWLRTREELENLSKDI
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus.
Sequence:
MPQTRDYQSPYVPALAQCPPRFPYLKTDAMSEYQLDVGLLTVTDVSTVSGPMRREEDLMSSCTNSLKALLGEFVDLPTEVKKTKYESAMTLVQLPQPVMQLPREKAPPKPKPLTAWQKFALKKGIDIHRKKANRVFDEDRQVWKDKWGKRAREDRDKYDWLREVKPGYMPAEDGGDPFLDDRRAKQARLEKQKKKEEHNKRRTEHLMQAQEEVKHLSAAARNLATASNGKFEKTKKFKKNTKRLA
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNLHESILTLAFCMQIAIGVLGNSFLICLFTVTVLSGQRMRPIDMILNQIAWANSLMIISKSIPQTLVAMNLKNFLNVYGCKFFFYLHRVSRGLSLSMTCLLSSLQAITISPRSSRWAEFRDKIPQYMIPTYSLSWAFHLLLNSIVLEKVKGPRKSRNISNILSYGYCSTSEATTVSTTLFIVVVSFPDVVCVWIMVFTSGYMVWLLYKHHKEVQHIHMANLSPRSSPEISATQSILLLVSTFVSFYSSNSILAAYIHLRKPGLWLVHSSTFLAACFPTVSPFVLLNTDSQLQRYSALFWRRNKPRFLPFSESLVPNQESDSLISSLLVE
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MDGSQGGSNSSPPFLTKTYEMVDDPLTDHIVSWSHTGSSFVVWNPPEFASELLPKYFKHNNFSSFVRQLNTYGFRKIDPDQWEFANDEFLRGQRHLLKKIHRRKPIHSHSTPPQGSTPATLSPSERQEYEDDIQKLKHETNSLRLVLQRHKQENQEYEQNFATLRERVQKIQLRHKKTMSFLAQILEKPGFLESNTRKRRLLITTYLHGEANADDNGNPDSIPLLNKLESSLKFWTDFVNDIVKVSGEETYDFGILAQPEKQVSGDFNEVSRVKSSGIDVNAAPAAATDGDGGAATVPAVQAGANDVFWEQFLTETPGGGDTQEVQSARRDVINKHDELGQRKSLWNTNNNLDKITEKMGNLSPSGKLDVR
The following text describes a protein:
Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Sequence:
MPFSSVKPQIHSLSFSTPVLYELEHLPPPTPNTANIFKHSSMIKNKHTFTSISRQDVSSIKDVQNTLDKGIRFGHTRSGNYIDICFLIKTDDRLSNLPTHCLPRVSVVMEGKAKITCLLNTSCSLADVIQDLCENHFMVASPDRQKNKDFSEPHILSDPESTLVANTYNFSNDYVLRVCETEELITDDKFYSSKVAHGTNLKLSLSAHLLAPSMCDSLADPVDNASLKKSVFLLQKYLKETEFRKHFLDVGGFIQLQKVAITAQQNTLAYTLGCIHTIIEQEWVSINQNLVSSSPTVLLDCTNVPLWCCFTNEFLEKLAFSLAVEVPGNIFKPITLICIWLLRSSTLSKSVDIFCKYIASQPSVLSNLVHCITSSYPEVQLGSLQLLNSLLTFPPERRRAVLMRLADSFGIRKSVAWLMNHHADQMFHESLIEFQHIVALDYFKGKHTKVDTELATHANVLDEIWSFADISSNGDKKWRLIGFLTETPTIELSRVGVLGLANFHFFICKNRKEYRQFVIDQLALSEEFRCPVARAAIEVCDVLLDVWQDFFKKSVISRYQPLFLLFEELFAITLRAFFRFWVDMDARQSESEIKRVVATLKSHIVSTLQSISDDEKVALDLFYKAMLQTSLTDIRSAQLKMNKQAEMTTCSDYLQAKAAINSSAREFIFQQRILTMRRGDFFSMANNDKSRSKTVRLYKLNAKCTKLMWIDFENTPTRDVADDKFPNHARVRDLIELKTQQASSKQSPDNALPCNLLFWASFKQSNKVFKSIILQTKDSKSPNIIDQRLPFQCNSTHQFMCWLDGLSMLMKESPIFFAGNETERYIHDVADNQFTLWQISQEGLKSPINYLPEIPSLPTSWDFWYDEKCMDPVFVTH
The following text describes a protein:
Function:
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
Sequence:
RLIRQVRNSRRRLLWLQENLIPGRTGNSSILVRILPSVYKKTVNSHQTALICCFAPEGRGADSAPDSFSFKKFSQLCGLSSKTPQEIRDVFQILDEDNSGYIEESELKFFLQRFLPGARTLTEAETKSFISAADDNSDGRIGVDGEYLVSHTVISKKP
The following text describes a protein:
Function:
Intermediate/inner baseplate protein. The gp25-(gp6)2-gp7 module is involved in sheath contraction. Involved in the tail assembly.
Subcellular Localization:
Virion. Note=Present in 6 copies in the baseplate.
Sequence:
MTVKAPSVTSLRISKLSANQVQVRWDDVGANFYYFVEIAETKTNSGENLPSNQYRWINLGYTANNSFFFDDADPLTTYIIRVATAAQDFEQSDWIYTEEFETFATNAYTFQNMIEMQLANKFIQEKFTLNNSDYVNFNNDTIMAALMNESFQFSPSYVDVSSISNFIIGENEYHEIQGSIQQVCKDINRVYLMESEGILYLFERYQPVVKVSNDKGQTWKAVKLFNDRVGYPLSKTVYYQSANTTYVLGYDKIFYGRKSTDVRWSADDVRFSSQDITFAKLGDQLHLGFDVEIFATYATLPANVYRIAEAITCTDDYIYVVARDKVRYIKTSNALIDFDPLSPTYSERLFEPDTMTITGNPKAVCYKMDSICDKVFALIIGEVETLNANPRTSKIIDSADKGIYVLNHDEKTWKRVFGNTEEERRRIQPGYANMSTDGKLVSLSSSNFKFLSDNVVNDPETAAKYQLIGAVKYEFPREWLADKHYHMMAFIADETSDWETFTPQPMKYYAEPFFNWSKKSNTRCWINNSDRAVVVYADLKYTKVIENIPETSPDRLVHEYWDDGDCTIVMPNVKFTGFKKYASGMLFYKASGEIISYYDFNYRVRDTVEIIWKPTEVFLKAFLQNQEHETPWSPEEERGLADPDLRPLIGTMMPDSYLLQDSNFEAFCEAYIQYLSDGYGTQYNNLRNLIRNQYPREEHAWEYLWSEIYKRNIYLNADKRDAVARFFESRSYDFYSTKGIEASYKFLFKVLYNEEVEIEIESGAGTEYDIIVQSDSLTEDLVGQTIYTATGRCNVTYIERSYSNGKLQWTVTIHNLLGRLIAGQEVKAERLPSFEGEIIRGVKGKDLLQNNIDYINRSRSYYVMKIKSNLPSSRWKSDVIRFVHPVGFGFIAITLLTMFINVGLTLKHTETIINKYKNYKWDSGLPTEYADRIAKLTPTGEIEHDSVTGEAIYEPGPMAGVKYPLPDDYNAENNNSIFQGQLPSERRKLMSPLFDASGTTFAQFRDLVNKRLKDNIGNPRDPENPTQVKIDE
The following text describes a protein:
Function:
Involved in import of methylthioribose (MTR) into the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGIFVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGELLAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLPAAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGMKGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTGMMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRDGLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIAVIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYFLYSRKHSLLNK
The following text describes a protein:
Function:
Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGTKKLVFVSILTALSIILSITIYFPILPQAPYLLYDPGDIPLILISTQVGISHGILATLIVAILMAVLTGQGGPIGALMHFLASGTLIVVSGYVYTKTKNLILGLTFGTISMAIVMAVANIIFTPIYLGVPRNTIYPLIFPVIIPFNLIKAGINSIITYILLSISLIRTYFEKMKG
The following text describes a protein:
Function:
Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
Sequence:
MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEEFDVSRQAVYDNIKRTEKILEDYEMKLHMYSDYVVRSEIFDAIMKKYPNDPYLQNKISILTTIDNRD
The following text describes a protein:
Function:
Influences the activity of genes involved in vulval development.
Sequence:
MKPGRKSLPKKNRASNITEKMPTTSTEAQSSSSKNQDRCRSFSQELGVDDEPEEQQAPVATPKQTKKAQKTAKTTEEVKSPRKSARKSELKKPEPEEKAKEPRKSASKRKSSSLMNKDEPSTSTEAPSADVPGTSEASDEASEIQEAPENPNSALAIKKRLMGGGESSKSAPTKNPPKARKSNVKKPEKEAEALAPPEPPAEPQEAAETPAPEPLVPEKKPKIEDAPTTSSPKKSTPTSAPPTRASARVSKPNRLYADGSFNTEILGRTRITEQNPVKEAQAKESTPELADLPLPAGRRKSTAAPRAPPAPKPIPVINGVLRGYIPSVKVPLAEYEVDGEIINLNEGVNETMDTILAKVCEDGVEKHEDIDPKVVKAKKLAKIDYTKRLKLQVKKLDIQMRIKIPSTPEELGKRKRQAPKTDDFYWSAQSRTKLKGSSKEREETPAFDEESPIGGDEKRQQKARESISHLFDAEMDASIKEAKKYSVSFDKYIKPKITGALKHAKIKLMSRKRQSAEPDDFYYHELLVDQVSPSNSNVENVDVDVDIEETDDKVDPTEFEISEEGVIGIRDEAVDMAEQIALVIPRPTKHDGSPMSMDEIQMRAMEHVESRTKCLDGSLEIVLNQLGHEMAPPTRGVEEQGCQWHTVTSANAQALKNLYTIANNCTEDAITWTHQFMIENLEVHMLASYLSILKYAKRLNSSRFGYVISSTDQLDPEWTQVTSLLKSFVYKRHTEPGTEVLNNTIPYHRMTDTVFLLVPPTLTFGDHQRAPPRHHARIFRWLQSIGHQDSEFISFDEDIDATCSVAEYLSDVIVERICDKVRQKNKYRPNCNVVLVGYGASTYLIHRAANLVEGISAIISIGFPVMTSLGRRGTADDEILLTYCPTLFIVGAEGRRFNNEAITELRTSMISPSGLVVVGHSNDMILVPTSMLLRLGISQTVVFRMVLEKILDFLNLEPVRQQEFADLVPIELNNVFDLDSALLKSDKALSGLAFASSTHSASSSAAPSPVGASGRRATVTGAGSEDIAKRRKESIILSQQIAAPSISGPPPPAPSPRTEDRFLAFQNLVASTITTGDDMPRRASMGASPRVIERGDFRDHRPPPPPPLPILQNPVATPMSQQPPLPSPAPPPPRGPVDPASISLI
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPDDLYRKAIARFWADFFNRKFLASRAAVLKTEGEEKEKAIAEFTENIMVLEDGFCKDFSDLQPFLNGKTFGYLDIVVGSSLAWIKVLEEITKERFLALEKTPFISSWMSNFCEVGVVKEVLPDHGKLLAISQGYRDRALSSSK
The following text describes a protein:
Function:
May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with PAPOLB in the endoplasmic reticulum.
Sequence:
MGLPKGFSSQRKRLSAVLNMLSLSLSTASLLSNYWFVGTQKVPKPLCGKGLPAKCFDVPVPLDGGGTNASSPEVVHYSWETGDDRFTFHAFRSGMWLSCAEIMEEPGERCRSFLELTPPTEREILWLSLGAQFAYIGLELISFILLLTDLLFTGNPGCSLKLSAFAAISSVLSGLLGMVGHMMYSQVFQATANLGPEDWRPHAWNYGWAFYTAWVSFTCCMASAVTTFNTYTRLVLEFKCRHSKSFRGAPGCQPHHHQCFLQQLACTAHPGGPVTSYPQFHCQPIRSISEGVDFYSELHDKELQQGSSQEPETKAAGSSVEEC
The following text describes a protein:
Function:
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
Sequence:
MINNQHNTWKLGNVFTFLCTCISILNRLKMSITDVLSAADIAAALKECQDPDSFNHKQFFQTSGLAKKSASQVKDIFRFIDNDQSGFLDEDELKFFLQKFESGARVLTSSETKSLMAAADHDGDGKIGADEFQEMVHS
The following text describes a protein:
Function:
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRSETVWIVDDDRSIRWVLEKALQQEGMTTQSFDSADGVMGRLARQQPDVIISDIRMPGTSGLDLLAQIREQHPRLPVIIMTAHSDLDSAVASYQGGAFEYLPKPFDVDEAVSLVKRANQHAQEQQGLDVPQNLARTPEIIGEAPAMQEVFRAIGRLSHSNITVLINGESGTGKELVAHALHRHSPRAASPFIALNMAAIPKDLMESELFGHEKGAFTGAANLRRGRFEQADGGTLFLDEIGDMPADTQTRLLRVLADGEFYRVGGHVPVKVDVRIIAATHQNLESLVQAGKFREDLFHRLNVIRIHIPRLADRREDIPALARHFLARAAQELAVEPKILKPETEEFIRNLPWPGNVRQMENTCRWITVMASSREVLIGDLPPELLNLPHDAAPVTNWEQALRQWADQALARGQTSLLDSAVPSFERIMIETALKHTAGRRRDAALLLGWGRNTLTRKIKELGMNVAGGDDEEGDDH
The following text describes a protein:
Function:
Plays a role into cellular response to oxidative stress. Decreases cell proliferation.
Sequence:
MSQATKRKHVVKEVLGEHIVPSDQQQIVRVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKDHVRSLQKDGFWPEAFSEVAEKHNNNRNRQTQPELPAEPQLSGEESSSEDDSDLFVNTNRRQYHESEEESEEEEAA
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Sequence:
MKEQKWIHEGLITESLPNGMFRVRLDNEDMILGYVSGKIRRSFIRILPGDRVKIEDFSRNPSSVVVND
The following text describes a protein:
Function:
Involved in F pilus assembly.
Sequence:
MASINTIVKRKQYLWLGIVVVGTASAIGGALYLSDVDMSGNGETVAEQEPVPDMTGVVDTTFDDKVRQHATTEMQVTAAQMQKQYEEIRRELDVLNKQRGDDQRRIEKLGQDNAALAEQVKALGANPVTATGEPVPQMPASPPGPEGEPQPGNTPVSFPPQGSVAVPPPTAFYPGNGVTPPPQVTYQSVPVPNRIQRKVFTRNEGKQGPSLPYIPSGSFAKAMLIEGADANASVTGNESTVPMQLRITGLVEMPNSKTYDATGCFVGLEAWGDVSSERAIVRTRNISCLKDGKTIDMPIKGHVSFRGKNGIKGEVVMRNGKILGWAWGAGFVDGIGQGMERASQPAVGLGATAAYGAGDVLKMGIGGGASKAAQTLSDYYIKRAEQYHPVIPIGAGNEVTVVFQDGFQLKTVEEMALERTQSRAEEDNPESPVPVPPSAESHLNGFNTDQMLKQLGNLNPQQFMSGSQGGGNDGK
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MTEKRRRCDGDGDRQLTQRPRCSDRGVSAPRTASDPRSFTVPRVHELSRQERVSLSKPQEVAYFSKYADDDVRFDRSNLVGAKLLDGFEEYTSKDEMNPLSPPAPIGPLLAALEHFQGEERTREQPHFVTYRNNLNKIMGTPYNSKNDWTFDVEKRGGESTDDGKGDNQRKVNEDEEFCSISAMTLGDKRLVVAAEIDCYDDKGAAREGGREYIELKTFRLLQREKDQFVFERFKLLAFWIQSFLVGTPKIVCAFRNDEFEVRKLQSFRVTEIPNFCRKHWSPVVCLNFTKALLDWIYAHAEDGRVYRITYIPRRHVVDMTLSSEPSFLPV
The following text describes a protein:
Function:
Part of the Notch signaling pathway.
Sequence:
MYLDTKNLTASSTSALTAATASNSKSTRRMRNVWKPLSRLLKVGGKGRTAQATLAHPNNVDLNNTQQQQQQQQQELLIEDDTKSTPEESIHKYGLELRQLPEEEQVSLTQPPNTPTLISSVHVDKVSAQSCGNCQHGRNCQHRHHSSSNINSSSSSSNMNSSSATQLPSNLWDLQLPLQYISTDNGTFFWANTQDRVDDDLLHALLCQSFSQLPGTLC
The following text describes a protein:
Function:
Hydrolyzes D-aminoacyl-tRNA into D-amino acid and free tRNA. Broad specificity toward the amino acid, but strict specificity toward the D-isomer. Seems to be required for ethanol tolerance.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MVTLIVATTADPASINPAAALLAMPGWTAGPILPPDIKSFSNKQTRVIQHDRSIVKEDDLDLRWEEATGEVVDEVIFLSRHTAVSNRPALTVHPIGVLHLKDGESPPQGGKPGWAALPSTRIGPWFRLLKKMAEAHGLVPEFEITLEATHHGPITNKPTMFLEIGSTEEYWKRQDAAQVMALLMWEGLGLGGSEEVGKWKSETGKRKVLLGIGGGHYAPRHMDIALKDDIWVGHLLSGYSLPMEDPTQTKTTPGENYIGGNWRQSIKAAFEATKASFPGGEILAHLDHKSFKGWQKKAITEFLAEESINVGKPNDFT
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the mus-8/ubc2 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSIDEAKEGGGGPAMSPRAFALAHQRDRGSFVGCSRIADYEVLGKLGEGTFGEVHRARSRKTGALVALKKIIMHNERDGFPITALREIKLLKLLSHKNVLRLEEMAIEHPPRTDKRTRPIVYMVTPYMDHDLSGLLDNPSVRFTEPQVKCYLLQLLEGLKYLHANHILHRDMKAANLLINNKGVLQIADFGLARHYEGDIPQPGKGSGEGKRDYTSLVVTRWYRPPELLMHLKRYTTAIDMWGVGCVFAEMLEGKPVLQGESDLHQLELVWDLCGTPSEETMPGWRTLPGGQAFSSKPRPGNLARRFEKHGPVVISLLKELFKLDWRSRINAIDALNHPYFRTAPLPALPGDLPTFEESHEFDRRKFQDRKAALPPAPKGGTVGRGAVVNSQGPDTGFSGRDGYGGGGRNGANGGRYPPYHRGPPPGDERVPSWHSARGLPPRPPMPADYHGSGPMDHTDGYRDRPPRRGPGGPPGGGGGPSNVDTYIPSYDRDGPAPRREDWRRRDDWDDRRGGVDRDRRRPEYDVRSRDSRTRSRTRSRSPVRDRDRGRDRDAYARR
The following text describes a protein:
Function:
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.
Subcellular Localization:
Nucleus.
Sequence:
MMQPTPAPSSAPGSPQRTQAEPEMETPSYPQPPQNVGTAPFSVLVKLFEKLATERKQERRRKLLDAWFRHWRREKGFDLYPVLRLLLPQKDRDRAVYGLKEKNLAKTYIKLIPLGMRDPDAIRLLNWKKPTERDKSSGDFPQVLCEVVSKRSSVIEGTLTIDELNEILDDIAKNMGKSDVQSKILRRIYNNSTADEQRWIIRIILKDMNISVKETTVFAVFHPDAQDLYNTCSDLKKVAWELWDPSRRLNAKDKEIQIFHAFAPMLCKRPTRKIEETVKAMGGSKFIIEEKLDGERMQLHKRGNEYFYCSRKGKDYTYLYGKHIGAGSLTPFIDSAFDSRIDDIILDGEMLVWDPVSERNLPFGTLKTAALDRSKKENNPRPCFKVFDLLYLNGMSLLDKTVKFRKNNLRHCIKPIPGRIEFVEEYQGETANDIRKRMEQVMENRGEGLVIKHPKAKYILNGRNTDWIKVKPEYMDNMGETVDVLVVAGNYGSGKRGGGVSTLICAVMDDRRPDSDDEPKYSSFVRIGTGLSFADYVWVRSKPWKVWDPKNPPEFLQTAKKGQEDKGDVYLEPEDSFILKVKAAEITPSDQYHMGFTMRFPRALAIRDDLSIADCMTATEVFESLKSERKRKMEDDAGITTKKRKTTVKKVALLPEYSGPNLKKVAVKTDIFNGMKFVVFSDPKSRTGEADKKELMKTIHANGGTCSQIVNKNSEAIVIYGGSITPYDLKLVIDKGIHDVIKPSWITDSVTLGEPAPFKKKYFFHATEERKYADEYNEDDGEEEGAVPSADEQERDVKSGTVEPGSETEDEDEEQAPEIKEEQDGELHEWLKVDDRKSPALPAHDEEDSVTEDDSDNADVADEEEPDLDDWFQVKGETEDEGAGALATASRHRETTPDVDGDVKMGESEEAMDYDPDVIFKHLCFYLDSPANAQRHGMATRPKYEAAITKSFEEVEKLIKDNGGKIVDLDEPKLTHVVLDKRDDSRRVELMKRTSKPRRRHLVLSDYIEACIDEGTLLDEEGESF
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MTEVKLPELGDGIESGDVLEIFVSVGDVITAGQDIVEMETDKATVPVPSDVGGKVTKISVGEGDTVPIGGVLIEVEAAAGAESAPAPAAPAEPEKKPEPKPEPQAEAPAPEPAAPPAAKPAAPAAPPVAQPVATPAARTPAVADEPDAPVDGGGSIPAGPAIRRFARETGVNLASVTGTGAGGRITRDDVLAVVRSASQKAAAPAAKPAPSAGTAAPRTNVTSGDLPGTPDTDDYGPIRVERMSKIRKTISAQMHLSWSTVPRVTNFDDADITDLERLRQSSKDDYAAQGLKLTTMPFLVKAVATALRHHPSLNAVIDSENQQVIYKDYVNIGIAVDTDNGLVVPVMHNADQMGIPDTARNIAEMAGKVRGGKFGVNDLRGGSFTISNLGAIGGQYSTPIVNVPEVAILLVGRSRKLPVVMPDDSIQPRLMMPLSLSYDHRLVDGGTAARFLNDVIGYLQAPSRLLLAL