lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Activates transcription in the presence of PBX1A and HOXA1.
Subcellular Localization:
Nucleus.
Sequence:
MMATQTLSIDSYPDGQQMQVVTELKTEQDPNCSEPDVEGVSPPPVGSQTPMDADKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTLSPQGIVVPASALQQGNVTMATVAGGTVYQPVTVVTPQGQVVTQALSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGAAQPAASELTVSEGAVVTITAPVSMNVDSLQSLSSDGATLAVQQVMMAEQSEDDSVDSTGDGGAALAPGHLGGLVLENSDSLQ
The following text describes a protein:
Function:
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
Sequence:
MIIHSLLDTDLYKFTMMQAVLHQHPAAQVDYRFKCRTPGVDLAQFIDEISREIDALCRLRLREDEVDYLRSLRFIKPDFADFLALFHLDRKYLALAASAAHPGEIELTIRGPWLHTILFEVPLLAIINEVWFRNTSEPDFEEGRSRLREKVRSLRSMPAGCKIADYGTRRRYSRQWHGELLPLLRDGLGEQFVGTSNVFFAKQYGLTPLGTMAHEYLQAFQALGPRLRDSQVAALDSWAREYRGDLGIALSDVVGLDAFLRDFDLYFCKLFDGMRHDSGDPFDWGERVIAHLEAHRVDPRTKVLVFSDGLNIDKVMRLYEHFSPRCRLAFGVGTSLTNDLGPTPLQIVIKMVRCNGQPVAKLSDSPGKSMCEDLGYLRYLRDVFGLPPMPEAGDPARQ
The following text describes a protein:
Function:
Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.
Subcellular Localization:
Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex.
Sequence:
MAGLPQNVQSTEAALQEAGSNVDIFLNKDKGFPALEDLISAARTGPATMSGTTENDFPSLAAPSIGLADLPLLGPTKKTPLPPELVEQFGHMQCYCMMGAFPGISRAWLSVDTDIFVWNYQDGGDLAYFDGLSETILYAGLVRPKPNIFRPHIRFLMCIATTVEIVLLGVSFSRPREDIDPDDFGQSEMHLIPEPLFAIPSDNSHITNIQGTKDGRIFLASKDGCLYELVYQAQDGWFSRKCRKVNHSSGVLSYLIPSMLQLSDKDPLVQIALDESRHILYTRSEQGTLSVYDMGSDGKDMRKVTSIYYSSILRETIAAAKTIDRSHFKQLIHIAAVTSHESSYIHLVGVTHSGIRLYFSTTRGQYGDVSKQRPSSLSLVHVRLPPGFTANMSSVRPTNVHVASYTKGCLMLCASQNEDSDRLWCLSHDAMPFQQTLMETQVSHQVDSRTWFICEIPSEDHITPRDDVSSISLSPSSKLRPVSSSSSSPASPSYSIPNPPAVVQQHALPAPRYVLLSSQGSIIISRLRPVDQLRQLMLNNMGPKCPAVENFFRLHKEDQASATCLILACSTASSDQTIADWATQAFFLYGGEPGGIMMDQQPPPVANLAAVFGATTPVVGQTGHDTTNRPFGSPGGATPGSMRPAVASTPFHQSTPANQPPMSGLPRYAQLSGKFQGLCLYYGRIVRPMWEHRLVKEVPVIGHQPLKTLMSLSTGSHELSSVLRDMKALKTFLEKNSQYTMMAENMANSMPSNNMMRGDSLVSGGPALQREHLRMRAEIYANERQSLMNLQKLVDMTVEVLDMLKLLCYHQFHVVAATLSQMDQEELKKITFRDLVLRGKEMCGSLITALINRYIGDNSTTEAISTRLREVCPSLYSANDATCTKANETLQAAMTAETKSVRDRLLRESLELFKEVSQQLNLAAICAEFHQAHYYDGVVDLCLSAAFKRDPHNLALIYYKNGKKPEDAHGMEAFSARFECYKSITDILDQLLSASQAQPSSPAVPNRPGSPPKPDPNRLSNTDAEHYFDAMMHKCLVSDDELFHVTLYDWLVNKGLKEQLLAIPSPFVEPYIKRAVNYNTDSLEMLDLLWKYHEKSKNYPAASRILLKLAERHSTDVKLQQRIEYFSRAVMCSKSSSLRTSSASEGEFLHEIEEKLEVARLQLQVYEAISQSCNHSDPHVQNALSVLDSELIDITKLYGDFASGFDLSRCKLAIVHCAGHFDEELIQELWREIIDKELYQSGDKLAATRMAILSKLLISLGKIYSTSERYFPLDFLVLHLEKKNCELDWSESWVFKTLLAADVPLLKLHCVYDRHFRAKDPFWQTSRNPQHMLRVIASLLSAFTDNAALVHLQDRRLFINSTLDAIASYKVELEATPGRPNIIQSYLASFNDLQSRLDRMQINRAR
The following text describes a protein:
Function:
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Also mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Its localization to the basolateral or apical membranes is tissue-dependent.
Sequence:
MLPVHTEVKPNPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRAKKDARKPSLTKAIVKCYWKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHTAYGYAAVLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLDELPERKAQEPSDGKAIVHVQDFTAFWDKALDTPTLQGLSFTARPGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEKERYEKVIKACALKKDFQLLEDGDRLVIGDRGARLSGGQKARVNLATAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSPVPGTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQDAENTQAAQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNVTGTLDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECRKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDIAFSSPAVMSTSNGQPSALTIFETAL
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with the EF-2-like GTPase RIA1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.
Miscellaneous:
MISCELLANEOUS: Present with 5060 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPINQPSGQIKLTNVSLVRLKKARKRFEVACYQNKVQDYRKGIEKDLDEVLQIHQVFMNVSKGLVANKEDLQKCFGTTNVDDVIEEIMHKGEIQLSEKERQLMLNKVNNEMLTIVSAKCINPVSKKRYPPTMIHKALQELKFSPVINKPAKLQALEAIKLLVSKQIIPIVRAKMKVKVAISEPSRQPELIEKISKLIASSPGESTKPELDPWTCTGLIDPVNYRDLMTLCDKKGTVQVLDMAVIDNTTHN
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MAQQQTNPEEVVLGQEAGGARVITLNRPRQLNGISDRVVYLLAQFLEKWEKDENAKLVIFKGAGRAFSAGGDLKMFYEGKSNDSCLEVVYRMYWLCYHIHTYKKTTVALVNGLVMGGGAAMVAPLKFAVVTEKTIFATPEASVGLHTDCSFSYIHSRLPGYLGEYLALTGARLNAKEMISAGLATHFVSSEKLEELEKRLLDLDTGEESAVRAVIEEFSTDVQPDEDSILNKLSIINKCFSAETVEDIIKAFESEASIDGNQWIAPVLKGLRRSSPTALKITLRSIREGRRQSLPECLTKEFRLTMNILRSVVNGDVYEGIRALSIDKDNAPKWNPTTLEEVKNEDIDRVFQPFSSERELQVPSDDSNRWSGKYENTVYGRAS
The following text describes a protein:
Function:
Activates the phosphorylation activity of the protein-arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs.
Miscellaneous:
MISCELLANEOUS: The mutant where Cys residues of three CXXC motifs are mutated to Ala (Cys-3, Cys-6, Cys-29, Cys-32, Cys-105 and Cys-108) is still able to bind Cu(2+), probably via its fourth CXXC motif, but loses the ability to bind Zn(2+), Co(2+) and Cd(2+).
Sequence:
MLCENCQLNEAELKVKVTSKNKTEEKMVCQTCAEGHHPWNQANEQPEYQEHQDNFEEAFVVKQILQHLATKHGINFQEVAFKEEKRCPSCHMTLKDIAHVGKFGCANCYATFKDDIIDIVRRVQGGQFEHVGKTPHSSHKKIALKRKIEEKNEYLKKLIEIQDFEEAAIVRDEIKALKAESEVQHDDA
The following text describes a protein:
Function:
May be involved in thymocyte signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MLAYSVTSSGLFPRMLWALLLLAASLNAHNDVWDEPCCTEHEVSVNRGSRVVMACNISNNLRDVTIELVTSEKTSIIFNHTPPGNYSKDSWQLHIQGVQAQLVITDAQDKHSGNYSWKLHGFQAEFKNFNLTVNAADRQKTEDLPVTKVPDKPPTAVRTEVIIIIAIATTIIITGIGVFVWYKQFPVAPQIQMSVPCLIHGSPGIPYLTLPP
The following text describes a protein:
Function:
Dioxygenase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2). Within the pathway, the dioxygenase af480 acts as a 5-dehydro-6-demethoxyfumagillol dioxygenase that hydroylates 5-keto-demethoxyfumagillol at position C-6. The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520. The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps. 5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene. The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin. Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (Probable).
Sequence:
MLGRHECTISESVSALDPTAQEPEYTLVPSTSRDLVRDMTLNMEDAQAHLKEHGWVKIPAVLSKAEAEDALSRLWEAKAASEARGECTFQPILDPNPANVRVFYLPELDAYWRDMLVNPTALDLAKSLLGDQLLVSNFSANIARPGAESMALHSDQSIVLPAPWLDVWAVNVIWCLTRMTKENGATLYIPGSNKWTTWEDVPDNAPDLLVPFEADAGDIVVIDGRLWHTSGSNVTEDEDRAILFAYYSAPHMRPLTNWSAKLPKELQETLSPQLKELLALSHIGYVVKGDLTYMAQKYPSEKGTTAVSA
The following text describes a protein:
Function:
Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.
Miscellaneous:
MISCELLANEOUS: The life-extending effect of mutations is likely caused by an alteration in energy balance caused by a decrease in transport function.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Note=Basolateral membrane of cells in the midgut.
Sequence:
MATETTKMIYTPPPLDIKMEIEIGEQPQPPVKCSNFFANHWKGLVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGVCKINHEPQYQIVGGNKKNNEDEPPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQIYAAAALGNKTH
The following text describes a protein:
Function:
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
Sequence:
MRLPEELLERARDIHSEAPSHRIKLDRVGSFGLKVPVEFKGFLLLAEADVWVSLPEGRRGVDLSRQVEAIYELSNPPKDPFSLCREAAISLLEKLNYADSSGVSIRFDAPLQDGESLKYYGVEISSIASDEIINKIRVEILGMTACPCTAELIRAYKSSEIAATHTQRSLGILEVSTKAEHPDPDKLASIIERAMSSPLRTYTKRPDEGGLVIRSLSNARLAEDVVREMIHLFLEEFGHLPEDTHILAAVRSMESVHMHDIYAERSFSLDEIRKEISSH
The following text describes a protein:
Function:
Involved in fertilization by controlling sperm migration into the oviduct. Promotes the binding of sperm to the oocyte zona pellucida.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Localized in round and elongating spermatids. Localized on the anterior part of the sperm head, and is removed during the acrosome reaction.
Sequence:
MLPLFLVLSYLGQVIAAGKDVETPLLQITVPEKIDTNIQDAKEAETQVTYVVRIEGKAYTLQLEKQSFLHPLFGTYLRDKLGTLQPYFSLVKTHCFYQGHAAEIPVSTVTLSTCSGLRGLLQLENITYGIEPLESSATFEHILYEIKNNKIDYSPLKENFANSEQESQSYRILVKPEKGSNSTLTKRILRIKIIMDKAMFDHMGSEVGVATQKVVHIFGLINTMFSQLKMTVMLNSLEIWSEQDKIETNGDADEVLQRFLLWKSKEISQKAQDITYLLLYKDHPDYVGATYHGMACNPNFTAGIALHPKTLAVEGFAIVLSQLLGINLGLAYDDVYNCFCPGSTCIMNPSAIRSQGIKVFSSCSVDEFKQLASQPELDCLRNTSETEFVVQPQGGSYCGNHLLEVPEQCDCGPPETCTHKKCCNPKDCTLIDAAQCGTGPCCDKRTCTIAERGRLCRKSKDQCDFPEFCNGETEGCAPDTKAADLEPCNNETAYCFGGVCRDPDRQCTDLFGKYAKGPNYVCAQEVNLQNDKFGNCHGRCNYSAIFCGKAVCYWNFAEVIQTEKYDVQYTYLGGQVCVSAHLRSQTGTRDDTYVHDGTVCGSGQVCFRGDCLRVHVLRGTRECEADDKCQGHGICNNLNNCQCESGFAPPECDMTPSSPGGSMDDGFWLPFDKSTPLIFKRHGLKYKKVLLISFYILLPFLVVLAFMAVKRMIGKRLAKQNISKALEHKEEAFNRGSMNPGVVSGGNTDQNLMTVPGSFNSYAYHGNTDQNFMTVPGSFNSYSYHGNTDQNFMTVPGSFNSYSYQDVPYYRSIPEDGNDSQQ
The following text describes a protein:
Function:
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSGRLLGLSSRRCPKTLEADPNGRLTWPEYLALRKQQRRYALFATIPITTLGLTLGVNYFATIEAAPTDLIMGIEAPYVYGLATLSCGLLGYLIGPSIGHAFFRLRVSKPTQRAMQDKNAQFYHHIKRHRVDPAQSIVNNPLPDWHGERIGSLKEYRKWLRDQSAYKRKATQHNMLLSSEDLNRGKDLL
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MKLKKNGYLGVFLTFLTPLLFYFFALAMAAIGGISVFVINVCVVVVLNMLYTAAGDSVGAKFGYTGPVGPNSWGNLSPTYSTCSNGKSQSPINIISDNCVINKNLKPLIMQYNHSEVATLVDNGFNVGIKYGDNAGRLIVGGKTYNFKQMHWHSPSEHTIDGTRYAAELHLVHFSEDNKIAVLAILFHLGHPDPLMTKLHNKMNELARDVATQKERQVQLSIDTHEIRKHSHKYYTYTGSLTTPPCSEIVTWYILGKVRSISKEQVEALKVLLDPTCKSNARPTQPINGRQIQIYEAQPNFQ
The following text describes a protein:
Function:
May play an important role in the persistence of mycobacteria in host cells. May regulate the innate immune response of macrophages by promoting the production of pro-inflammatory cytokines and inhibiting the production of anti-inflammatory cytokines. Promotes the death of macrophages during infection.
Miscellaneous:
MISCELLANEOUS: Expression in M.smegmatis enhances the ability to resist in vitro stress and early survival in macrophages. Macrophages infected with recombinant M.smegmatis produce significantly greater amounts of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha and an early decrease in IL-10 along with higher levels of host cell death.
Subcellular Localization:
Secreted, cell wall. Note=Cell wall-associated.
Sequence:
MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGREYAAVAEELGALLAAVQAGVWQGPSAESFAAACLPYLSWLTQASADCAAAAARLEAVTAAYAAALVAMPTLAELAANHATHGAMVATNFFGINTIPIAVNEADYVRMWLQAATTMATYQAVADSAVRSIPDSVPPPRILKSNAQSQHSSSNNSGGADPVDDFIAEILKIITGGRVIWDPEAGTVNGLPYDAYTNPGTLMWWIARSLELLQDFQEFAKLLFTNPVKAFQFLVDLILFDWPTHMLQLATWLAENPQLLVAALTPAISGLGAVSGLAGLTGLVPQPPVVPAPAPDAVVPTVLPLAGTATPTTAPASAPAAGAAPGPPAGTATATSASVPTSAGGFPPYLVGSGPGIDFDAGTPAGSRRAQPAADNVTAVAAAQVSARHQARRRRRAAAKERGNADEFVDMDSGPAIPPSGERDAWASNSGVGGLGFAGTASNETVAAPAGLTTLADDEFQCGPRMPMLPGAWDLGTWDRGD
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MNELVQILKNTRQHLMTGVSHMIPFVVSGGILLAVSVMLYGKGAVPDAVADPNLKKLFDIGVAGLTLMVPFLAAYIGYSIAERSALAPCAIGAWVGNSFGAGFFGALIAGIIGGIVVHYLKKIPVHKVLRSVMPIFIIPIVGTLITAGIMMWGLGEPVGALTNSLTQWLQGMQQGSIVMLAVIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTVVAIAAVGICIPPLGMGLATLIGRKNFSAEERETGKAALVMGCVGVTEGAIPFAAADPLRVIPSIMVGSVCGAVTAALVGAQCYAGWGGLIVLPVVEGKLGYIAAVAVGAVVTAVCVNVLKSLARKNGSSTDEKEDDLDLDFEIN
The following text describes a protein:
Function:
Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins. Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO. Has no catalytic activity towards oxidized glutathione (GSSG).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-77 of isoform 1; MISCELLANEOUS: In Plasmodium, the C-terminal redox center, which acts as the active site, is formed by two cysteines while in mammalian TRXR this redox center is composed of a cysteine-selenocysteine active site.
Subcellular Localization:
[Isoform 1]: Mitochondrion; [Isoform 2]: Cytoplasm.
Sequence:
MNNVISFIGNSSNKYFQINQLHFIRIINKNIHSKNNLINSNSSYNVFYNKYFIKNTFQNKNKLSSIYSKLNFSIKNMCKDKNEKKNYEHVNANEKNGYLASEKNELTKNKVEEHTYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKLMHYAGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDDIFSLKKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYMEEQGVMFKNGILPKKLTKMDDKILVEFSDKTSELYDTVLYAIGRKGDIDGLNLESLNMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIMDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKDEYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGIHPTDAESFMNLFVTISSGLSYAAKGGCGGGKCG
The following text describes a protein:
Function:
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing of homologous chromosomes during meiosis (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSKSKEAAASSIILKYLNDQNRPYSTQDVFSNLQRDHGLGKTAVVKTMELLAQKGKIKEKVYGKQKIYFADQEQFPSVSDSELKDLDAQVTELSSKLQSSQQSCRQLESELKDLTSSLTTEEMLKEVSCLKEECDRHEHKLTNIKSATNHVTPAEKEKVYGERKHFCKEWKKRKRMATDIFDAILEGYPKSKKQFFEEVGVETDEDCNVTVPDV
The following text describes a protein:
Function:
Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSANARDCLLHLARAKLSERQDLVQLNDQFVDIIEHVHYMEAEHTALEHDYNLLKSGVQSDSSGINEIYNVEIRTVRSGIEEINRSRHELLNEQTQLSHQVKEAEQLWRHTAKSALGVPKEVDDEFHRICHIKMEDCITKRRIKYMEDKLRLIKQNNGRIFEHINLMRMRKDQAVSLQQEYLLRKNELLHSIRNMEEDNKKIIMNEHKYFVRDRNADRHVFRDQLRKAIADIRADYEANRLRNEEEIRIRLEREIHRMNTTMPGVVCYDKLREELSIVKNNLSGLQKQVSEVEIRNNSLTQQIEFYRLEISENNKLFEDTLEFKIKEIEKMREQCTAISVELEKLCDLNIDLQKEIAKYRELLDRSGDPRANAPSTQVIASALSRQNYSSISDHHSRTSSGIVQHTAHHAVRDSSSSRTGTTIHETITHTPIPIPATLPVQPIREYTYSRDASPIRPSYTPYQQESRADSRSSLRERIQIETLQGTLPVLPSHSVETIRASDNTRLVRDLSAGGQINTTQINNPYASRTPTSSVNDRIASERRDSEIRRNDALHQPYPIGGAVPRVEPTIFNERAPGYTHINSNFPLITPVTEGATVPSYYDTFNRNSSQRGPHHSSYHAATGSVSNSISTTLLNEGSIEHSSSSDSVDEDNFQRFTRWYKGRVKISDVTADFVQLVNRSSKKSADVGGFKLIHEFGNKSVYVDLPVGLILAPKDSLKIYARGATHERGAVIAEIDFFDTTIHTNTSIRNTNNEVKSWFVYTSNTEIGDADHHHH
The following text describes a protein:
Function:
Immune regulatory cytokine.
Subcellular Localization:
Secreted.
Sequence:
MAPLSHLLSVLALFTLLAGTSSSPICNNRCCRFVESFPVRLRKLRHDFAQIKDFYEANDDLDSALLDQTVEDSIKSEFACQTIDSILDFYLKTILPKAAAGYPDDTADVKPHVLSIQEIFDQLRTDVTQCRNYFSCKKHFEIRNLTAAYDEMQNKGLFKAMGELDLFFNYIESYLASQRRV
The following text describes a protein:
Function:
Transcription factor which binds specifically to the palindromic sequence 5'-GGGAAATCCC-3' in the alpha-A crystallin promoter.
Subcellular Localization:
Nucleus.
Domain:
Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between.
Sequence:
MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKEVLEAGVKGTSESLKGVKRKKIVAENHLKKIPKSPLRNPLQTKHKQNTEEPPFSVLPSASESHKKHNCVPAKQGRQFTKQNGETPGMTAESSESGDLVSPKKTSSPHQRSELRRWRSEGSDPTRLSGLDGQRDSSSSSSKARTDNSECSSPCCSTTPPSYTSTAFDVLLKAMEPELSTLSQKGSSCAIKTEKLRPNKTVRSPSKLKNSSLDAPNATSPDLVVESPCPPCTSYPVHVASTQKSEQVAAQCVSHLYSSQDHLVPKLSQQNQQLPGHLGFTGSLTNLHTLESTKLEPIYNTAVTSTVGLTSPSTRTQVTPPHQQMDSVSPLSVSPASSTQSPPGPIYSSAHVASVVSQSVEQMCSLLLRDQKPKKQGKYICEYCNRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPEAGGLFLSQECPKALSVHSDIEDSGESDEEGLADGRQNNPCVKDLQPVQTMKTVSNPESLPKLIPSNSDHVVRGFSSQDRPSDSQAPTELPKVVVHPVSMPPLKTDCLQVANPNPELPSPQSPRDLHVASILSHSASVSSLEMDESCHQKGDVIQSEGKPDSHSGTAHAQLQRQQATEDPQEQQGKLLLSPRSLGSTDSGYFSRSESADQAVSPPTPFARTFPTMDPDPAKNGGAPGPRISAPAPSALATGEKSSVVTGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPMGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAIPANIIPPPPSLRGSQSFDDKIGTLYDDVFVSGPNPSMPPSGHHRPLVRQAAVEDSTASESHVPGSGQSVDESCQGCPSSSEAGPVQSKAAQTPHLEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKAAVREAEHGPAPGGAQPQVLHYRVAAPTAVWEQTPQIRKRRKMKSVGDEEDLQPHESGRSPESADALQLQPVPGAAPSPSKHTSATAADQAHRGVQLVARGPERALPLKQCPMVEQQLNAAAQDKMEVKRQGGGISVIQHTNSLSRPNSFDKPEPLEGGITFSLQELGRTGMPGALKVIGMAPEEGHPPQDAMHQTALSHNLRGEPRESARKIPSERYVLGQPLRLVRQHNIQVPEILVTEEPDRDLEAQSHDEEKSEKFTWPQRSETLSKLPTEKLPPKKKRLRLAEIEHSSTESSFESTLSRSLSRESSLSHASSFSASLDLEDISKVELAPKIDFPSKAEFLLIPLGSNTLSVPGSHREMRRAASEQISCVPTLMEVSDFRSKSFDCGSIAPSHVVPALVESQPSYSPSAVGGTAHVPLLERRRGPLIRQISLNIASDSHLSPGSAAALQTIVLPSVNTVPFQAPRLPDMASADCPAHTVHPQALAKDLQAEISSSSSTDTFPPQQLFGAHLLNKTNTSLSHQNTPLPLPVSAQGGKPDAAPTACVSSTGEGSFAPKYQLQCQAFTSDQGCSAPLRSSPNQVLPGQAGADPCPASEAPPAKAADPMAKPCPLPPLELGLPRDEVLQKQLPSFVLPVPQKRNVTVDCFTPVTSLPQILVTQDLPNMPICQTNQSLVPVSEEQNSMPKSQNYLQNASPTPEKELACKTVLPEVGQSVPVSESSPTVQKVSVGRLSPQQESSASSKRMLSPANSLDIAMEKHQKRAKDENGAVCSTNIRALELPSSRANESHKQKKPVLVRQLCTTEPLEGAALEQGACSASGRSSNKAANLTQVLPTDSLSSRPSTFAVTDHVNELQEFKNTKVSTSLTPTVGSFPAPSESACVLPLKSIDNNQEKGSPGVRHEENKVIQGQRPPLVSGLSLVSSSDTQQPSFPSLKTATSFTWCYLLRQKALPLAQNDQKTSAYTGWTVSSSNPNPLGLPTKVALSLLNSKQKTGKSLYCQAITTHSKSDLVVYSSKWKNNLSKRALGNQKATVVEFSNKDDSEINSEQDKENSLIKSEPRRIKIFDGGYKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYHCSYCNFSFKTKGNLTKHMKSKAHSKKCVDLGVSVGLIDEQDTEESDEKQRFGCERSGYDLEESDGPDEDDNDNEEDDDDSQAESGLSAAPSVTASPQHLPSRSGLQDPGSVEEELRVSSCFSGVHTDPMDILPRALLTKMTVLSTVQSSPNRTDLPAKARQSTEKDEHEQAPPADTPRSPGHQLSVHSSESDVLRSPAAGNPAAGSPGAAVQDSSVGLPPAVAQLNPQPAARISSSVSPHPDSQDQKQQIILQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVTAGLTYSTFVPIQAGPMQLTIPAVSVIHRTVGTSGDTITEASGSPNRPTGVAELSSVVPCIPIGQIHVPGLQNLSPPALQSLTSLGMETVNLVGLANATVGPQGHPPGLALNAVGLQVLANAPAQSSPAPPAHIQGLQILNIALPTLIPSVGPVAVGTTGTPETTAPNSKAMELQMPAGQGHSAEPPQGSPEGPQETPQTVSGPSADHARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTPEALQKVATSAPPSLPTDRAAPRPPVPHRQPIVHFSDVSSDDDEDRLVIAT
The following text describes a protein:
Function:
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.
Subcellular Localization:
Cell membrane, sarcolemma, T-tubule. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Preautophagosomal structure membrane; Single-pass type III membrane protein.
Sequence:
MGAVWSALLLGGLAGALLAWLGRGGAGGAGVPGGRAGRQRPPPGTSEPAAAATERCQEDRLAAPAPTDGSLDPETPGAAPRGPSDDPDPEPGAPSVRLPDPRGRVSPELADPLPRDAAGLATGGPPDPGGRETGSPPRGREGAGRPQGLTPKRDPTAAGGGGGPLAATGGPEPDPGAELVPAAAPTPRPVSLRFRVHYVTRSAAQRLAVAGDHRALGAWEAHVPLRGDEGGFWSRSLSLPGETRLEWKFVVVEDGKVVRWEEGPNRRLDTGHQDAEVWRWWGRP
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MAGSSARAAAPIVPTVVFVFLLLLPLSAVRHARAQESDSEDEFSYRSGRDNSPDRWGLLRSDWAACYWGRLQSPIRVPGPGPVAGPRNGRLACTYRSSPATLVNRGHDIMVRFDGNAGSLVLDGVSYRLRQMHWHSPSEHALNGSRYDLELHMLHQSDKASNKYAVVAQLFQIGEHRDEILHMLEPFIERITDRRKGYEEEIDYEVDPRRPVRGSDTFYRYTGSFTTPPCTEGIAWAVATKVRHVSRHQVELLKDAVHDHARRNARPLQEANGRGIALYDSWPRSGPGN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAASLLLRQGRAGALKTVLLEAGVFRGVAPAVSLSAESGKNEKGLPPNPKKQSPPKKPVSAAPTEPFDNTTYKNLQHHDYSTYTFLDLNLDLSKFRMPQPSSGRESPRH
The following text describes a protein:
Function:
Involved in cell resistance against acid stress.
Sequence:
MENNEIQSVLMNALSLQEVHVSGDGSHFQVIAVGELFDGMSRVKKQQTVYGPLMEYIADNRIHAVSIKAYTPAEWARDRKLNGF