lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the formation of pseudouridine at position 31 in the psi GC loop of tRNAS.
Miscellaneous:
MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MSTIKVIEVYTQNGLRKVRPYYNRRSAFVKGRWLGKLLIDVLVSEFKLRPRAYYLDQIRKGTYRLIRDGVPLVPDHLMTTIIKNHDVLETTTHKHEPPVKQWCSQEVEAEDLPGRIAGFNIVFEDESILVIDKPSGIPVHPTGQFYQNTITELLKLHGVDALPCYRLDKITSGLLILAKNSQSAGEIQKSIRSRDMIKIYLARVKGRFPHSELILDNENAAETTFEDTSKVTVEMTPIYSIDPKRQFPVGLSTSKDAITKFYPIRYFSHADETVVACKPITGRTHQIRIHLARLGHPIVNDSVYCSHITKYPERLKFITQFPRWENQQDLDAEELKVRFQKFVDETKNNCRTMETFCPECHTVDLKDPVLSDLELWLHAWKYEEINGKFKFKTDLPKWAQLDNS
The following text describes a protein:
Function:
Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
Subcellular Localization:
Cytoplasm.
Domain:
The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.
Sequence:
MRNFDLSPLMRQWIGFDKLANALQNAGESQSFPPYNIEKSDDNHYRITLALAGFRQEDLEIQLEGTRLSVKGTPEQPKEEKKWLHQGLMNQPFSLSFTLAENMEVSGATFVNGLLHIDLIRNEPEPIAAQRIAISERPALNS
The following text describes a protein:
Function:
Has a role in meiosis.
Sequence:
MTESERTSHLDILYENQRGIMLCGVPYFSEKSLLNFDPAPWVDQHFVASPVSTKTATCPDPSWEWAWQRWYIDMSGDVDESGWQYGFSFTMNNWHGKPVSLHSFVRRRRWIRKRKKKELRRDELPLVPESFTISSSYPIQRSSTQTRSSFEDDSSDFDLSEVTTIPALLRALQDSRIDREKLEALATFLASASIDEKVYVKNCKKDLLKNFVFEHSCRKANELLNASLTAAEASTSQVALRESPTPQD
The following text describes a protein:
Function:
Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded, thereby facilitating ribonucleotide turnover.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MRVGVQGCCHGILDNLYILAEKRKVDLLIIGGDFQALRNVSDYHGISMPPKFKRLGDFFNYYNGRNKAPILTIFVGGNHEASNYLDELPYGGWVAPNIYYMGRSSVINVGGLRIAGISGIYSAMDYKKGRYEGLPYNYKMLKSIYHTREFDVLSLKSLQKPIDIFLSHDWPRGIEQHGDVAKLLRHKPFFRNEVERNDLGSPALEELLVELKPRYWMAAHLHTKFTAVVHHNSQEDDGKLSCSSKDVTSSGFSMKGLNEPSQERLPVEKEQNDKSDEEGSNNEQEEKQDKKQSTNRDLCRKESCKKEPSLSSSDQVTKFLALDKCLPRRSYFEVVEIEPVEIPDSGAPYMQYDSEWLSVLRAMHPFQSHTIEQDPPLPSLEVVKTLKRKEEIWVDENLVKKDKLGIPRNFCQTAPPHSRDITENMQPSSYINPQTVAFEILIGLKERTVDSPPPVKNPNEIVL
The following text describes a protein:
Function:
Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively. Sexual experience, the NPF system activity and ethanol consumption are all linked; sexual deprivation is a major contributor to enhanced ethanol preference.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIISMNQTEPAQLADGEHLSGYASSSNSVRYLDDRHPLDYLDLGTVHALNTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCSDTNVALNGHTTGCNVQAAARRRRKLGAELSKGELKLLGPGGAQSGTAGGEGGLAATDFMTGHHEGGLRSAITESVALTDHNPVPSEVTKLMPR
The following text describes a protein:
Function:
Stabilizes the tail structure and acts as a connector between the end of tail and the portal vertex of the capsid.
Subcellular Localization:
Virion. Host cytoplasm.
Sequence:
MAIKGLEQAVENLSRISKTAVPGAAAMAINRVASSAISQSASQVARETKVRRKLVKERARLKRATVKNPQARIKVNRGDLPVIKLGNARVVLSRRRRRKKGQRSSLKGGGSVLVVGNRRIPGAFIQQLKNGRWHVMQRVAGKNRYPIDVVKIPMAVPLTTAFKQNIERIRRERLPKELGYALQHQLRMVIKR
The following text describes a protein:
Function:
Phosphorylates the DNA-binding protein Rv2175c. May be involved in the regulation of cell division and cell envelope biosynthesis.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MVEAGTRDPLESALLDSRYLVQAKIASGGTSTVYRGLDVRLDRPVALKVMDSRYAGDEQFLTRFRLEARAVARLNNRALVAVYDQGKDGRHPFLVMELIEGGTLRELLIERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPFTGDSALSIAYQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLEAIAEELALPEFRVPAPRNSAQHRSAALYRSRITQQGQLGAKPVHHPTRQLTRQPGDCSEPASGSEPEHEPITGQFAGIAIEEFIWARQHARRMVLVWVSVVLAITGLVASAAWTIGSNLSGLL
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTKLFDALRYNFSLQFVSRLLSFGINMYLLRVVDSSVIGLVNVRLMLLYDTVLFLTREPMRKASILNENLQRFVNLIWLSPLISMALCGVIVPLWMYGSSTPLALPVVLSFAGSAVIEALAEPFCVISLRFSLDKHFAVSQGLLIALKRVFIFALILDTPIDHLTLFSVAQIVAAVAFTLFNYAAFYRYAVSGKAELASFRSYRDFFPRLEEGFDAGSIKAVSTLLAHSVLKQLLTDGSAFVMTFTRLLTLPQQAVYDSIERLGSLVSRLLLAPLEESSFAYFSNAISSAKNSVFKQNTDSHDVLVRTFTALMRDLIVCGLVVSAFGVPYSGVAVSIYGGQVLVANGGASLLATYAVYILIIAINGVTEAFAFATMNVEQIFSHGGFLLVSSLVHLSLSYALCLQFGAIGFILANMANMSVRIVYSWRHINKYLGMKCPSVFALLPSFGTIVFMGFALMGGLFSLVLFGSTPGLSHTLSHLAVGGVLFVMLALHIWQAERPFVTLMKKTQ
The following text describes a protein:
Function:
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Subcellular Localization:
Cell membrane. Nucleus, nucleolus.
Sequence:
MAAHKPVEWVQAIINRFDEQLPIKTGQQSTHTKVSTEHNKECLINISKYKFALVINGLTNILKNVNNMRIFGEAAEKNLYFSQLIILDTLEKCLAGQPKDCLRLDEAMLVKQLLPEICHFLHSYREGQQHATQLRSSASAVLFSLSCNNFNAVFSRISTRLQELTVCTEDTVDVHDIELIQYINVDCSKLKRLLQEAVLKFKSLKKPAQLAVISSLEKAFWNWVEHYPDDFTMLYQRPQADMADCAERLFDLVDSFAESAKRKAAVWPLQIILLILCPEITQSITKEVGGEEKANKKSFVDSLRKALGQHSGSKQLTESAAVACVKLCKACTYINWEDNSVIFLLVQSIVMDLKGLLFNPTKPFSRGTGCQSADVDLMIDCFVSCYRINPRNNQHFKVCLASTSPPTFHFVLVNSLHKIITNSHLDWWPKIDAIYCYSGELRTMFADTLGRVIQSLSAHPPLRMTSSLTFKEKMTTSLKFKEKSTDLDSRSLLLALVKLIHADPKLMLHNPGKPGQEIQNSTAEIIKGLVQLVPLTHSAELSQEAMEALLVLHQPETIELWNPDAPIETFWDISSQVLFLICKKLIGHQMINSTEILKWLREILICRNKFLLKNKECATQGSLIPISRQAQTKLEVCLYTFLWSPDAEAVLVAMSCFRHLCEEADIRCSVDELPVHTVLPNYNTFIELASVSNMMATGRNTLQKRVMALLRRIKHPTAGNVEAWEDTYAKWEQATKQILNHPKNKVEDGQVVNIRLVNYFIFFSIHGHLFSVRPQEWINMTGFLCALGGVCLQQRSTPSLGTYSPPMGPLTERKGSMISMSSCEVNSETSLNRFLERLLALMVCTHEKVGVQIRTNVKDLVGLELSPALYSMLFTKLRNSIGRFFDTQGPVPITDANTLFVEQTIAIMKNLLDSHTEGSSEHLGQASIETMMLNLVRYVRILGNIVHAIQIKTKLCQLVEVMMERRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEEDGQQVAGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGAAYLQKLLEPLLRGIITTPEWQQISFEVDPTRLEQAENLEENQKNLLQITDRFFLAIINSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDSPPSDSVNHSLSFISDGNVLALHRLLWNNQERIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLNIFYQAGTSKNGNPVFYYIARRFKTGQINGDLLIYHVLLTLKPYYAKHYEIVVDLTHVGPSNRFKTDFLSKWFVVFPNFAYENVAAVYIYNCNTWVREYTKYHERLLTGLKGSKKLVFIDSPARLAEHIEPEQQKLPAATLALEEDLKVFHNALKLAHRDTKVSIKVGSTAVQVTSAERTRVLGQPVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLRNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTLLVATGPLSLRASTHGLVINIIHSLCTCSQLNFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALSSLETVTEALLEIMEACMRDIPGCKWLDQWTELAQKFAFQYNPSLQPRALVVFGCISKRVTHGQLKQIIRILSKASPLLSIDRGLESCLKGPDNYNSQVLIEATVIALTKLQPLLDQDSPMHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRVFNDKSPEEVFMEIRKPLEWHCKQMDHFVGLNFASNFNFALVGHLLKGYRHPSSTTVARTVRILHTLLGLVGKHRSCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLSEVTMENFPMDTYTVYDTEPGCRLLRENQPWASPKVSERSLAPPYSTIGQTSLRPRKSMSVDMGQPSQANAKKLLGTRKSFDHLISESKAPKRPDMESGITTPPKMRRVSENDYEIETQRIANSHLRKVSVSESNVLLDENVLTDPKIQTLLLTVLATLVKYTTDEFHQRILYEYLAEASVVFPKVFPVVHNLLDSKLSTVLSMCQDPNLLNPVHGIIQNVVYHEESPPQYQPSCLQSFGFNGLWRFAGPFSKQTQIPDYAELVVKFLDALIDTYLPGIEEEGGEESLRTPTSPYPPTVQSQLSITANLNLSNSMTSLATSQHSPEGPIVYRRSPTLSHPRTTEEVPPKTAACLPCSKSAVFPPHLVLPGIDKENVEISPTSSLSTSGRMRHGSASQVQKQRSAGSFKRPSIKKIV
The following text describes a protein:
Function:
Peptidase involved in the biosynthesis of the enzyme cofactor mycofactocin (MFT). Catalyzes cleavage of the MftC-modified MftA peptide to liberate its final two residues, which consist of a cross-linked valine-decarboxylated tyrosine dipeptide (named 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one or ADHP).
Sequence:
MNSSYHRRVPVVGELGSATSSQLPSTSPSIVIPLGSTEQHGPHLPLDTDTRIATAVARTVTARLHAEDLPIAQEEWLMAPAIAYGASGEHQRFAGTISIGTEALTMLLVEYGRSAACWARRLVFVNGHGGNVGALTRAVGLLRAEGRDAGWCPCTCPGGDPHAGHTETSVLLHLSPADVRTERWRAGNRAPLPVLLPSMRRGGVAAVSETGVLGDPTTATAAEGRRIFAAMVDDCVRRVARWMPQPDGMLT
The following text describes a protein:
Function:
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MMSANYISTLMLSSSLRTSITNNQAALSKASKEATTGRFADVGLELGATTGGDLTLRADWSFADQLVDTNELVSGRLDVTQTRITQLGTTATSFLKDLIAARSTDNGGRIVLPPASANLQDLIGALNVSYNGSYLFSGINTQNMPITAYATGSASKNQVDADFAAAPPTGFGFPQSSASVSSITPAQMQTFLNTTFDAEFASPAWNTNWSSATDQVMQSRISTTEVADTSVSANQTGFRKLAEAYTMMADLGNAKLSQETFQVVVDKAIGLIGGAITDLATLGGGVGTVQQRITSATNKLKTQQDILNNQIVGMEKVDPTEASVRVNTLQTQIQTALALTSQLQKISLINYL
The following text describes a protein:
Function:
Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor (By similarity). May be important in C-cell development and, in the postnatal development of the adrenal medulla (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform A]: GPI-anchored form.
Subcellular Localization:
[Isoform A]: Cell membrane; Lipid-anchor, GPI-anchor; [Isoform B]: Secreted.
Sequence:
MLSGAYLRVLNERPGQAVLWSLGCQRGSASSTEGNRCVEAAEACTADEQCQQLRSEYVAQCLGRAGWRGPGSCVRSRCRRALRRFFARGPPALTHALLFCGCEGPACAERRRQTFAPACAFSGPQLAPPSCLKPLDRCERSRRCRPRLFAFQASCAPAPGSRDGCPEEGGPRCLRAYAGLVGTVVTPNYLDNVSARVAPWCGCEASGNRREECEAFRKLFTRNPCLDGAIQAFDSSQPSVLQDQWNPYQNAGCCFLWVSSMSILTALALQALL
The following text describes a protein:
Function:
Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
Subcellular Localization:
Secreted.
Sequence:
MKTLSPTGYGLLLVLPLLLAVLQSTTAHKNDINIYSLTVDSKVSSRFAHTVVTSRVVNKGSAVQEATFQMELPKKAFITNFSMIIDGVTYPGNIKEKAAAQEQYSAVARGESAGLVRATGRKTEQFQVAVSVAPAAKVTFELVYEELLARHLGVYELLLKIQPQQLVKHLQMDIHIFEPQGISFLETESTFMTNELAEALTISQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNFIVRYDVNRTVTGGSIQIENGYFVHYFAPEVWSAIPKNVIFVIDTSGSMRGRKIQQTREALIKILGDLGSRDQFNLVSFSGEAPRRRAVAASAENVEEAKSYAAEIHAQGGTNINDAMLMAVQLLERANREELLPARSVTFIILLTDGDPTVGETNPSKIQKNVREAIDGQHSLFCLGFGFDVPYAFLEKMALENGGLARRIYEDSDSALQLEDFYQEVANPLLRLVAFEYPSNAVEEVTQDNFRLFFKGSELVVAGKLRDQSPDVLSAKVRGQLHMENVTFVMESRVAEQEAEFLSPKYIFHSFMERLWAYLTIQQLLAQTVSASDAEKKALEARALSLSLNYSFVTPLTSMVITKPEGQEQSQVAEKPVENGNRQGNTHSGHSSFQFHSVGDRTSRLTGGSSVDPVFSHRRGWKGQAQGFEKMSYLPPRLGPPGPLQPTRFSHPFSRITLDRVLPEVLSVPDETSHDMDSRIIGATIPPPPARIQAPSVILPLPGQSVDQLCVDLKHSQGPVKLLSDPGQGVEVTGHYEREKARFSWIEVTFKHPPLQVRASLEHIVVIRNRQSSAYKWKETLYSVMPGLKITMDKAGLLLLSSPNRVTIGLLSWDGPGKGLRLLLRDTDHFSSQISGTFGQFYQDVVWGPPAAADDSKRTVTVQGHDHSATRELKLDYQEGSPGKEISCWTVVL
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAKVTGLPEFEDLHTKRKWMLNHMAAAFRMFGRNGYNEGTAGHVTVRDPIDENTFWINPLEVPFSLMKPSDLVHINSDGEIIGGSKMKYNTSGFAIHYEMHKVRPEVICVCHVHSIYGKAFSALGKPLDMLNTDCCVFYNNHGIYFDMDDVISMPEEGRRTAKGLADYKAVLVQNHGIMTVGTTVDEAAYLLSLMERSCQIQLLIDSATKVGERKHVHPTRAKAIRENADNPVGLYTAQQPNFLYEVACSNGELEII
The following text describes a protein:
Function:
Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4. Seems to be involved in the abscisic acid (ABA) signaling pathway. Could also be able to hydrolyze PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
Sequence:
MKTRRGKRPERFWPSIVMNKWLNRKPKVYDFSEDEIDTEPESEDDVCSVKDVPNVHCVTDEDSHNGRRGSEADHGNNISDGGVSVRGGYQRKHRRGKSETLRAQYINTKDIKVTVATWNVAGKRPSDDLEIEDWLSTDNPSDIYIIGFQEVVPLNAGNVFGAEDRGPIPKWESIIRRTLNKSNKESVYDQSPSCNNNALHRSHSAPSSPILAQEANSIISHVMVENLVADHSLDLATNEFIDAATALPSLEPQRNPNMDWPELALDSNPQIVGSEGKLRRVFSSNATLGFKLPENPSGASRFASEARQLKRSRSFETLNLSWNDIKEEIDNRSSSSSEAEEAAKIMHDDSSDGDSSSQDEEDGDKIRNSYGLPEDLVEECRKVKDSQKYVRIVSKQMVGIYVSVWIRRRLRRHVNNLKVSPVGVGLMGYMGNKGSVSISMTLYQSRMCFVCSHLTSGHKDGAEQRRNADVYEIIRRTRFASVLDTDQPRTIPCHDQVFWFGDLNYRLNMSDGEVRKLVSQKRWDELKNSDQLIRELRRGHVFDGWREGPIKFPPTYKYEFDSDRYAGENLREPEKKRAPAWCDRILWLGKGIRQECYKRSEIRMSDHRPVTSIFNVGVEVFDHRKLQRALHVNNAAASAVHPEPSF
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MLFEESQTDDLKAWLTSELGPICDADPEVLADYVLALLKHEGPEAELQTLLTEQLEDFLAAETASFVSKTFQAIADKAYLPASESAQANQSSDSHPFASTSTTAQDTSPSSRKRRADQDTGDAARSPPRQTRRLQDNNATPSSDDSRAGRARERDSRERAATTDGLDANGSQHEGGRREHRPKQLCRDYHNKGFCPRGANCKFEHSADTMPGNADARNQQQQLHQQPRFHHMGGIMGPAGPNAMHGPPMMFPGAPFGMPPQGWHPSMGPPPGMALNSAGSGASPSHTNGDAQNLANRMGGQLPPESPDANHFGNQAGSFNGGMGPGGRGGAMGGRGRGRGGGPPGTFQSSRRSNTTLVIENVPAESLDLIKVNEYFKKFGTITNISIDKPGSKALVSYSQPGEAKAAHESPDVIFGNRFVKVYFQRLDEAAAGAPVAGPSPVPRPPPSAAATRGGFVPGKTSNVYHARPPVAGASTYGGGSTGASGGMSEERKRLLDDQRTKQAALDAQLAEQKALLAKFGDKNLSAEDKKQTMTQLKQLGDQIKVSTEAVKAAVEAVQTAPKETSAGDASTANWKAEKEKREKEQLDRELDLHAQGSSPASTTEELKQKLESLKAEAASLGIDGGASSGAGYGYNARGRGRGGAYIPRGRGGYTPYAARGGAGAMGPNRSLRIDNRTTRLKIDNLPTGADTDKLKQHFAAFGELESFDADTATLVYKARNSAEQALRAGAEIADVGTVKLSWIQPPTPAVAAPVTAVSTDERTNGGDKANANERGDEEFDEDRDSSWKR
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
EMNHTVITEFVLLGLSDDPDLQIVIFLFLFLTYLLSVTGNLTIITLTLVDSHLQTPMYFFLRNFSFLEILFTTVCIPRFLGAIITRDKTISYNNCAAQLFFFIFMGVTEFYILTAMSYDRYVAICKPLHYTTIMNRKVCTLLVLCAWLGGFLTIFPPLMLLLQLDYCASNVIDHFACDYFPLLQLSCSDTWLLEVIGFYFALVALLFTLALVILSYLYIIRTILRIPSASQRKKAFSTCSSHMIVISISYGSCIFMYANPSAKERASLTKGVAILNTSVAPMLNPFIYTLRNQQVKQAFKDVVHKVVFSSSK
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MSNPNLNLINEITTILASNDDAEAVENAAVELNEVIHYRKLEQEEIFNSIRQLTAKTESDSEKLLKLDGTSQNRTIGELKTATKKLSSEIKGIETEIKLVEHGIGERKKMLEEKRKEQESETSELLPKTKYNFKLYTNISHIRWNYESEDDHIAGFIACLKNVKPFDLNAKQNSEYFIANYLWDMIETSID
The following text describes a protein:
Function:
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Also encodes a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
Subcellular Localization:
Virion. Host cytoplasm.
Domain:
The N-terminal region is important for the cap-binding activity while the C-terminal region contains the 3'-5' exoribonuclease activity. A CCHE zinc binding site is present in the C-terminal region and may thus contribute to the substrate binding and/or the specificity of the exonuclease activity.
Sequence:
MANSKEVKSFLWTQALRRELGQYCSTVKSSIIKDAQSLLHSLDFSEVSNIQRLMRKDKRNDSDLKRLRDLNQAVFNLVELKSTQQKNVLRVGKLTSDDLLVLAADLDRLKNKVMRTERPQTLGVYMGNLTNQQLDQRKRLLDMIGISNARNAPRPGADGVVRVWDVKDSSLLNNQFGTMPSLTLACMSKQGQYELNDVVQSLTDLGLVYAAKYPNAMDLEKLTQAHPVLSIIDVSKSSINVSGYNFSLSAAVKAGACMLDGGNMLETLKVTPQNLEDILASMLKVKRAHSMFVSDTPGDRNPYENLLYKVCLSGNGWPYIACRTSLTGRAWDNTVVDLGPPIDLSQNKQMSPAKPKGAGHGMPSGLTMSQILALKDLMAAVDPNAKTWIDIEGRAEDPVEIAFYQPQTGAYIHFYREPTDAKQFKQDSKYSHGIDIGDLFNVQPGLTSAVLELLPPNMVLTCQGSEDIRRLLDSQGRKDIKLIDVLMSKSEARKFEDEVWDKFGFLCKIHTGHVVEKKKRGNKEEITPHCALLDCLMYEAASTGRFSPGSIRAVLPRDMVFRAVTEKVAL
The following text describes a protein:
Function:
Probably facilitates nickel incorporation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTDSQTETHLSLILSDTAFPLSSFSYSYGLESYLSHQQVRDVNAFFNFLPLSLNSVLHTNLPTVKAAWESPQQYSEIEDFFESTQTCTIAQKVSTMQGKSLLNIWTKSLSFFVTSTDVFKYLDEYERRVRSKKALGHFPVVWGVVCRALGLSLERTCYLFLLGHAKSICSAAVRLDVLTSFQYVSTLAHPQTESLLRDSSQLALNMQLEDTAQSWYTLDLWQGRHSLLYSRIFNS
The following text describes a protein:
Function:
RNA-binding protein that plays a role in the inhibition of multiple cellular antiviral responses activated by double-stranded RNA (dsRNA), such as inhibition of PKR activation, necroptosis, and IFN-mediated antiviral activities. Recognizes and binds Z-RNA structures via its Z-binding domain and dsRNA via its DRBM domain: RNA-binding activity is required to escape host ZBP1-dependent necroptosis. Mechanistically, the Z-binding domain binds Z-RNAs that are produced during vaccinia virus infection, thereby competing with Z-RNA detection by host ZBP1, suppressing ZBP1-dependent necroptosis. Acts as a key inhibitor of the interferon response by blocking the phosphorylation and subsequent activation of IRF3 and IRF7 kinases that are required for interferon-alpha gene expression. Inhibits NF-kappa-B activation and the ubiquitin-like protein ISG15, which is an early antiviral protein. The binding with host ISG15 subsequently blocks host ISGylation.
Domain:
Contains a dsRNA binding domain (DRBM) and a Z-RNA binding domain. The Z-binding domain recognizes and binds Z-RNA structures.
Sequence:
MSKIYIDERSNAEIVCEAIKTIGIEGATAAQLTRQLNMEKREVNKALYDLQRSAMVYSSDDIPPRWFMTTEADKPDADAMADVIIDDVSREKSMREDHKSFDDVIPAKKIIDWKGANPVTVINEYCQITRRDWSFRIESVGPSNSPTFYACVDIDGRVFDKADGKSKRDAKNNAAKLAVDKLLGYVIIRF
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MHKFLPIAYFEDKFVPFEDAKISVATHALHYGTAAFGGLRGIPDPEDPGTILLFRLDRHGDRLSKSAKFLHYDISAEKIKEVIVDFVKKNQPDKSFYIRPLVYSSGLGIAPRLHNLEKDFLVYGLEMGDYLAADGVSCRISSWYRQEDRSFPLRGKISAAYITSALAKTEAVESGFDEAILMNSQGKVCEATGMNVFMVRNGQIVTPGNEQDILEGITRDSILTIAADLGIPTCQRPIDKSELMIADEVFLSGTAAKITPVKRIENFTLGGDRPITEKLRSVLTAVTENREPKYQDWVFKIPLNG
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MQVCWFERFGGGNQLLTVLSSSRTCYARFVNFKVFKRMENYRLRRNMPRTGPCKLLLPLSCGISSSVLLHILNAQIQHELAKSHPSPGFDLHLLVIEPSSISHSSLSYDEGFELLQQTFPLHSFTRIPLHSIFELDPELQEVISQFSKDGFVDDTGLSAKERLDAFRASIPTSTSKVDVDYILITRLVVAFAKKIACRGVLWGDTDTRLAAKTLANVAKGRGSSLTWQVCDGMSPFGVEFNFPLRDLFKAEVDNYASFFPELTRIIIPDEPPSENVLTKNLSIDELMMRYVQTQGEKYPGVMANVTRTASKLQASLMPANVPQCSFCGAFMLNSGNNDGGDTTGASRALELCYACIRSRPELTC
The following text describes a protein:
Function:
Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death. Represses the transcription of CYP2A5. Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2. Required for the development of natural killer cell precursors.
Sequence:
MNVDGLSLPNISQSPSKVLWGTRRGLTTRRQREFMPEEKKDTVYWEKRRKNNEAAKRSREKRRLNDVAIEGRLAMLLEENAILRAELQALKLQFGLLPSMCGPRMLPLQAMLWKSSWTGESHPGADSFLPLPGGHGCLFKPYAVDSGIPGCSGCLVAQGWPGLTDSPRFLEESQPLPHRIVDRTFHTAFPAAVFGCHFLDRHVGTRPELKTCCGLWSPIPTGSHAPGSSGISMTSSESSMEFSPGISCPVSDDRSEGRAKTSLPHKLRIKSQASRGSC
The following text describes a protein:
Function:
Functions as a co-chaperone for protein folding in chloroplasts.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAASFIILSSPFASSTLSFSNKNPTGFQRSSLRVNAFATKYEPTKVVPQADRVLIRLEALAEKSAGGVLLPKSAVKFERYLVGEVLTVGAEVEEVKAGKKVMFSDVSAYEVELGTDDARYCFCKAGDLLAVVE