lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for correct biomineralization of the magnetosome, maybe via redox control. May function with MamY, MamZ amd Mms6 in biomineralization (Probable).
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)).
Subcellular Localization:
Magnetosome membrane; Single-pass membrane protein.
Domain:
The C-terminus of the protein cannot be tagged, suggesting it is required for function.
Sequence:
MNTKAVAHPDIAVWIMALGIAFSMALVLTALFNANPWEDHTYDLAPPIVAGMAAPHRDGREKMVCSSCHIVTPASAATGPGAGTLPIVEGTPAPHVDGREKMACASCHTIVKKGSVAKSGKASPAPVAFSQGMPLPEAMSVALAVTPAPAPLGNEAHERMVPFRYQGKIVSVAGAGTRSVWGDIYIQINDGINPPMWIDLAPLWFLQAEGCLVRPGMFVKGTAFRDPTQASAGLDYAMSVMANGEVCALRDDHLNGLWANVGGVDAEER
The following text describes a protein:
Function:
The erf2-erf4 complex is a palmitoyltransferase with a major role in driving sexual development. Palmitoylates ras1. Palmitoylates isp3. Palmitoylates rho3.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MLVRIERDYSVSGDKYPQFPTDYPVPLRAYVNLEDWDVFIHTLNEKLREAFCPWSIGNLLDGILSVLTIYISEFVFGSIHRKRIGAIDLYILDFATQHNLYVASLRNMGFLSLVFHTKETNSKSSTLHSNPYCPEHHSIRTLPSAVTATTSNISTSSSHRSDLPNEWTNSTL
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins. The first step in the biosynthesis of sterigmatocystin is the production of hexanoate by the fatty acid synthase (FAS) units stcJ and stcK. The polyketide backbone is assembled by the non-reducing polyketide synthase stcA by condensation of the starter hexanoyl-CoA and 7 malonyl-CoA extender units followed by cyclization and release of norsolorinic acid (By similarity). Norsolorinic acid is the first stable intermediate in the biosynthesis of sterigmatocystin and is converted into averantin (AVN) by the ketoreductase stcE which reduces the hexanoate ketone to an alcohol (Probable). Averantin is then oxidized into 5'-hydroxyaverantin (HAVN) by the cytochrome P450 monooxygenase stcF. 5'-hydroxyaverantin is further converted to 5'-oxyaverantin (OAVN) by the 5'-hydroxyaverantin dehydrogenase stcG. The next step is the conversion of OAVN into averufin (AVF) which is catalyzed by a yet to be identified enzyme. The cytochrome P450 monooxygenase stcB and the flavin-binding monooxygenase stcW are both required for the conversion of averufin to 1-hydroxyversicolorone. The esterase stcI probably catalyzes the formation of versiconal hemiacetal acetate from 1-hydroxyversicolorone. The oxydoreductase stcN then probably catalyzes the biosynthetic step from versiconal to versicolorin B (VERB). The next step is performed by the versicolorin B desaturase stcL to produce versicolorin A (VERA). The ketoreductase stcU and the cytochrome P450 monooxygenase stcS are involved in the conversion of versicolorin A to demethylsterigmatocystin. The Baeyer-Villiger oxidas stcQ and the reductase stcR might be involved in the biosynthetic step from versicolorin A to demethylsterigmatocystin. The final step in the biosynthesis of sterigmatocystin is the methylation of demethylsterigmatocystin catalyzed by the methyltransferase stcP.
Sequence:
MISQICNEVIGLVPKKEEPGWLSVTGHPGAVYCENSISSGPEATGADVSQAIRIAYFTPLKHIPGPWYASLTGLRLSWSVFANNRIHYVHSLHQKYGPIVRIGPQEIDVADPVAGREIHRMGSGFMKAPFYELLSPGPVDNIFNFRDPKLHAARRKLYARGFTLQSLRNEWEPKVRDIIKLTVEKIKCDAVKGEAEIMGWWTLMANEIVCQLTFGGGAGIVAKGVKEPFVLMLERRMGDLAHLLKHFAPPGYYLGRALAWFIPPLQDIFYSQERMFAAGGDVVSRAREAKKAQAEPRNLFNKALEAGNLTDTDIITDAGALLLAGSDPTAISLTFLLWCVLSRPEVQKQVEAEVATLEGELTDEACERLPILNAVIDESLRLYGAAPGCMPRSPPSGGVTIGGYFIPDDTIVATQNWSLQRNPSIWDDADTFDHTRWLSNSRITDQAKLAFNPFGYGARQCLGIHLGRMEMRLAAAMFFRECVGARLGRSVTDESMHVVDSFIAGVPRDRRCAITLT
The following text describes a protein:
Function:
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MANEAYPCPCDIGHRLEYGGLGREVQVEHIKAYVTKSPVDAGKAVIVIQDIFGWQLPNTRYIADMISGNGYTTIVPDFFVGQEPWDPSGDWSIFPEWLKTRNAQKIDREISAILKYLKQQCHAQKIGIVGFCWGGTAVHHLMMKYSEFRAGVSVYGIVKDSEDIYNLKNPTLFIFAENDVVIPLKDVSLLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREDCSPADKPYIDEARRNLIEWLNKYM
The following text describes a protein:
Function:
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQCYTELLSPSGVTHALAIPFLSASAENLVVVKTSVLQIFSLLKVQHHSRGETIETKSARPDQVETTKLVLEREYPLSGTVVDICRVKILNSKSGGEALLLAFRNAKLSLVEWDPERHGISTISIHYYERDDLTRSPWVPDLSSCGSILSVDPSSRCAVFNFGIRNLAILPFHQPGDDLAMDDYEFHLHQDDLNQVSDHVGNGLKSKDSTVYQTPYASSFVLPLTALDPSILHPVSLAFLYEYREPTFGILYSQIATSHALLSERKDSIFYTVFTLDLEQRASTTLLSVPKLPSDLFKVVALPPPVGGALLIGSNELVHVDQAGKTNAVGVNEFARQVSAFSMVDQSDLALRLEGCVVEHISDSTGDLLLVLSSGNMVLVHFQLDGRSVSGISLRPLPTQAGGTIMKSAASSSAFLGSGRVFFGSEDADSVLLSWSSMPNPKKSRPRMSNVAEDREEASDDSQSEEDAYEDDLYTAEPETPALGRRPSAETTGVGAYIFQTLDRLPNIGPLRDITLGKPASTVENTGRLIKNACSELELVAAQGSGRNGGLVLMKREIEPDVTASFDAQSVQEVWTAVVALGSGAPLVLDEQQINQEYRQYVILSKPETPDKETSEVFIADTQDLKPFRAPEFNPNNDVTIEIGTLSCKKRVVQVLRNEVRSYDIDLGLAQIYPVWDEDTSDERMAVSASLADPYIAILRDDSTLMILQADDSGDLDEVELNEAARAGKWRSCCLYWDKAEFFSSTGPALKQGTRCELFLFLLSIDCRLYVYRLPDQQLISVIEGIDCLPPILSTELPKRSTTREVLSEAVIADLGESWNPSPHLILRTESDDLVIYKAFASYIKGESHTRLSFVKESNHTLPRVTTSEKEMQSNEKLSRPRSLRILPNISNFSAVFMPGRPASFILKTAKSCPHVFRLRGEFVRSLSIFDLASPSLDTGFIYVDSKDVLRICRFPSETLFDYTWALRKISIGEQVDHLAYATSSETYVLGTSHSADFKLPDDDELHPDWRNEGLVISFLPELRQCSLKVVSPRTWTVIDSYSLGPDEYVMAVKNMDLEVSENTHERRNMIVVGTAFARGEDIPSRGCIYVFEVIKVVPDPEKPETDRKLKLIGKELVKGAVTALSQIGGQGFLIAAQGQKCMVRGLKEDGSLLPVAFMDMQCYVNVLKELKGTGMCIMGDAVKGLWFAGYSEEPYKMSLFGKDQGYLEVVAAEFLPDGDKLFILVADSDCNLHVLQYDPEDPKSSNGDRLLARSKFHMGHFATTMTLLPRTMVSSEKAMANPDSMEIDSQTISQQVLITSQSGSVGIVTSVPEESYRRLSALQSQLANSLEHPCGLNPRAYRAVESDGTAGRGMLDGNLLYQWLDMGQHRKMEIAARVGAHEWEIKADLEAIGAEGLGYL
The following text describes a protein:
Function:
Activates the phosphorylation activity of the protein-arginine kinase McsB. Is required for the delocalization of competence proteins from the cell poles.
Sequence:
MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISANQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSECYKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFENAAHVRDQIRLLEQSLKSTDSEEEQE
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSAFAALKNNPFGESIFNNTSNGDNHSRDDVEEDEVVQYIANSSDEDDDDDNDDNDNDQGNEDNNLFPLEISAPVDTSISSTPAPILNSRITQSNYTPNESNLKFSDNHVTITLNPSEYIIISGQCNLKIIKGSIKINQCHCLTSEDNKSYNIIALQSQSLPIISHYTTPEMEEDGVTSVSIIQLENSFSGIENISQIEPAFKNLISGQPNVEEPSLFKNYSFDIVLTETNGGYGLDINSYWINELNLLKSNKDDPTPKIIMIIGNKNTGKSTFCKSLINELLLTNPNRPVSYLEIDPGQSEYSTPCALSLSEIVQAQFGLAALPHKNNNIVKSRVEHYFGFTSAVNAPTRYVEIIEELFNHHQTKFSQRNHLIINTPGWVKGYGKELLNQITKIINPDKLILLSNNLNQEYPDNANILQDLTYQSLSIIPGVYQLSKYSAPQIRTINKLLYFHQTTTTGTFNFNDHLLDSSPLKISYACGNSPNNPGIYSTTIINHNIDNEFSHRDLCSLVEVSIYGIYSIKSNGNTKFDEMSCFRRDDGNSPFYLNPDDFDNLLSNETITSKFIGLIMVHSINPNDHYMNIYAPDIIINRLRKVLSTNSNQTNDYKLIMIRGEGDIPNCEMLYPEFINKKIDYLKSIKKRKAATTSRKLVDLKLPYISFETKSKVGGIWKVRKNIKRRGHHQKG
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVERTYNSIRTHKQTRLSQRPISKKTSSTMRETFGLDSEKNSENVFYFRSQVLRELEMKNRMECPSLDEIFSFYHFPWEKFRYRKNSQKKKRSTLYSFYFEQVNTCYFNIIIFPCQKDGTRLYCKYHFLCGKFSFLNFISKPQIQIISACTSMRTSVTYLLIFSTYSLLPMSFMLMIFSTFSLTFLVAFLGVLSDYTIGYDIILTRIMMVILVNVVGSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDMQDTHEERMFHKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKILGDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWSNDVTLANQMESGGLPGRVHITDATRKYLKGAYILEEGNGASRSKFLEKEKIRTWLVVDRSPDYDMICEETTNHPLTIPWKSTRGISKQERLTGMSTRTRGASTRNGLSEEEVLVDNVDSHLRQGIQAIHQENWKSMYCKEWSLKYKQLRVENKFVRMKYKDIPFQVTLYVVTVSICTGIKFGWASLNMFSFIPQMFILITSIIIFILTRVLIKYARLVGMVTSVLFVLLSMQIVVLMAMYQSKLSCDLESCFKNSYTDFFEIFEICTLATCVILSVDFLTKLVMSLIYFSSFIVLITMKLLSIDNNQNLFSTYANFCVLACVTLLLLVFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVLENILPSQVAKHFVEDATSVSKLYHESRDNACIMFATLTAFDKFYIECDGNNEGVECLRLLNEIISDFDQILDRSEFKKIEKIKTISTTYMVASGLAGEECADNSHVEAIALFARELLLKLESINIHSFNDFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKTILEPLGYKFECRGQINVKGKGMMTTFFLLPPENYECQLYK
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Subcellular Localization:
Mitochondrion.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MGIGSKILENNIQKSISLGFYHSHSELRKSFYEFFKSKNHEILRSSSVIPDENDGTLLFTNAGMNQFKPLILSSTESRRVANIQKCIRAGGKHNDLDDVGKDLHHQTFFEMMGNWSFNDAFSKEEACRYAWEYLVEILGINADRLYVSYFGGIEKLGLPEDRECREIWKRIGVSSNRILPFVAENFWEMGAAGPCGPCTEIHYDRIGGRDASRLVNIDDSVVEIWNIVFMSSVRDSCGQIRHLGKNHIDTGMGFERLLSVVQNKTSNFDTDVFTPILEKTSELAKKQYTGSLDSRQDATFRLVADHIRAATVAISDGAVPDGTGCGFIVRKMMRRAFLQGISKLGIERYAMSELVPVVASTMKEVYPEIHDTSTHIRKIFNDEEAQFWKTVDKAKKMFDSVAAESKSPIISGRKAFNLFETHGLPLAVTVELARNIGREVDETEFERCRLEAQKVSQKASQFKLPISADDFPSHSDKEKYSYVFRNGKYEFPQVKTRILQVYKDQQKAESLEANDRGFLVLEECQFYGEQGGQTSDTGHLLIDGREVFEVENAKKIAGGAVTVLFGRALLPIRRDLRVEQKLDETRREGVMRAHSATHLLNWALQKLGVGSGQKGSSVDCDRFRFDYSTGDEDLSKEQRTELLIKCEMKMREFIQNGGFTEIIETSLEEAKKIENLQSDVKEDRIGGASVRVVALGSGADVPVECCSGTHIHDVRVIDDVAIMSDKSMGQRLRRIIVLTGKEAAACRNYTKSIYEDLRSTDPKERSKTGKNIDWKRVPIADQARISILLKQKK
The following text describes a protein:
Function:
Involved in regulation of various organellar membrane contact sites. May be involved in sterol transfer between intracellular membranes. Selectively transports sterols between membranes in vitro. Involved in stress-dependent formation of sterol-enriched vacuolar membrane domains.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes to intracellular puncta representing endoplasmic reticulum-mitochondrion membrane contact sites (ERMES), nucleus-vacuole junctions (NVJ) and vacuole-mitochondria patches (vCLAMP). Localization to ER-mitochondria contacts is dependent on TOM70/TOM71, and localization to ER-vacuole junctions on VAC8.
Domain:
The VASt domain bind sterols.
Sequence:
MWGDSMRELGDAMDNELNAVKPVVEEGGMDGARKFIKGKSFQKSSTEHMLISPGRDGSVPLNGLKSSPADPHLSDVNSILDNHRGGGETALTSVNNIIMATSTNGDSDGVDGDAKRPSISNCSSRSSFFDTVLSTFSLKSNSQDTVTNEVKNIEVQFASEEANKKFRQMFKPLAPNTRLITDYFCYFHREFPYQGRIYLSNTHLCFNSTVLNWMAKLQIPLNEIKYLDKVTTNSSAISVETVTNRYTFSGFIARDEVFQLITRVWSKENLTNINDVLEVDERVSKKKGISSTPSSIFNNVSTNAYNDFISTTTTEPTSRASYMSENDMLIEEAIRSVDDYMGTPRASPSSSSSSSSSSSSLGSSTTYYCRPVYRLKPNAPFQYEGPFHVQETMDFPYKPEANNEYVLLERQFSVPPGLLFIMMFNEDNPVFELSFLKTQDSSNISHIGTFEKVNKDGQHYREFQYTKQLHFPVGPKSTNCEVAEILLHCDWERYINVLSITRTPNVPSGTSFSTRTRYMFRWDDQGQGCILKISFWVDWNASSWIKPMVESNCKNGQISATKDLVKLVEEFVEKYVELSKEKADTLKPLPSVTSFGSPRKVAAPELTMVQPESKPEAEAEISEIGSDRWRFNWVNIIILVLLVLNLLYLMKLNKKMDKLTNLMTHKDEVVAHATLLDIPAKVQWSRPRRGDVL
The following text describes a protein:
Function:
Probably binds the 23S rRNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MTVQRFIEYTPFDSNGQQLPGESRKITLNVLLEDSGNYLIHRDILRHQLSQKQGTVSTKTRSEVRGGGKKPWRQKGTGRARAGSSRSPLWKGGGVIFGPKPKTANLKLNKKERNLALQTLLYNKRDIITQVSTLDIKNVKTKEFYNFCKEKGFNLNEKLLVIDSEKTTPLKLSTRNLKNVELISASNLNTLSLLKAKKILVTTSALNDIKEIYCG
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Sequence:
MNRSDLLENPRTQTESGFLLIHKPVGMTSSDLVVTVRKKLGFKKVGHTGTLDRAASGLMILPIGSCTSFSSVFLEKEKSYEAWVKPGESTDSGDKEGEILESLSKEQTETWFQEHQEKLRNLFEQVPTWETQEAPEVSALKVNGRRRSDLFREGVALVPVVRKIKIYRYELGKFSPESISFQIRVSAGTYIRKIVMDISDRIGFPLRLEKLVRTSIGKLNLNQADSYESLLDGKIKIHPPETILDFPTVEVPDTEVRNVLNGRKIKLEWIPVNEFLLVSPEEEILAWCKKEEHGIHELDYKYLRVFPKN
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
Sequence:
MPTNSYKINPKATKSIHYTLYYGTFIHTPDLTTLEINFNTLVGVNEQGTIDFIHKDYDASLYNNKSPIQFFIDQREHPHSQPHQENHGQQRYQHFEFVDYSHDLTKFFIPGFIDTHIHASQYPNIGIGLGTPLLDWLKKYTFPLENHFCQSGQEQQQEQEQETKLQFANEIYNQVIQRTLENGTTCASYFTTIDPETTNLFAELLLINGQRGFVGKVCMDHNEPYQEYQESIEDCEKSMHKIINHIEKLNTNTNTNKNLVTPIITPRFAPVCSDKILKFLGELSHEKNLPIQTHISENKQEIELVDKLFPDCENYASVYNKFNLLTNKTILAHAIHLTPKECQLIKLKNCSISHCPTSNTFLSSGEAPIYKYLYHDNINVSLGTDVSGGFDYSILQIIKHAILVSHHLNMHKSNTTTNTTTKNDVDERLSIKDGIYMATMGGAKAVGLQDIIGSFEIGKQFDVQLIDLSTRQINYHYHSHNHNHNHNHNHNYNYNYTIPTISDNSSRIDIFNWQYPVNKDLDKMKDLLGKWIFNGDDRNCIKVWCNGRLVINKEKYNHRDDRWVITNSNGHNSDRFTTNTNTTTTTNTTTATNTATTTQMNGNQDNWEYV
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSVPPSGHRQVSLRGSSAREITRDALLQKVSEERQLRSHLRRAAAAAITIQRVWRRYHVIRKVSEQLHEEWDALINNQLDVNPTNQWISSKMLRPFIFFTTQPSSWYKGKQTKTVKSISTCFKIILNSINSMDASKNFCSFAMGLPEERSIWLYQAKKLISLCSCILAMRDHSYCKDVNMVEITAIAMRLAISLTDCKTWKNLKSGNVKAADASVETLIEFIGASHSGTYSCVRRYIKSFGPHVNSGKIDPATAPDDQLLITASAVTVALRPFQSARADMGVDLAGVAKEYFTLVLTIPYLCKRLPPLLLPALKHISVLQPSLSIVLTSKDKIFEEIAKLEQSEVSSVGASIIPYCGWALGNLVNLATEQDDVSNSGCFIQGLDCCLYINAINFISQNLLKSFEESKGMLQYVGDSDAATSVTEETDTDDNSCMRILFMDLLKPVYQQWHLRKLLALAKEDVSRKRETNHDPTLKQIHSRSLKLTDVICFYYYMLRIFSLLSPSIASLPILNMLSFTPGFLVDLWGELEISIFGQPIHKSQESEHDKQFATSSSGEQISSTRQRRNAKDTAGKWVNVLQKITRKSSDADDTNLSGIPLNSENSNDDALIMWDIGAMRQGSEGIGKDLIHMLHLFCAIYTHLLLVLDDIEFYEKQVPFTIEQQRKIASVLNTFVYNSFIQNSGSNNRPLIDVTVRCLNLLYERDSRHRFCPISLWLAPARTGRIPIAAAARAHEAAFATLSGTTSGIATRSSVLTTVPHVYPFEERVQMFREFIELDKASRRVTGEVSGPGPGSIEIVIRRGHIVEDGYRQLNCLRSKLKSCIHVSFVSECGLPEAGLDYGGLSKEFLTDVSKAAFSPEYGLFSQTSTSDSSLIPSNSAKLLDNGIDMIEFLGRIVGKALYEGILLEYCFSQVFVQKLLGRYSFLDELSTLDSELYRSLMQLKHYEGDVEDLCLDFTLTEEFGGKRIVHELRPGGKNISVTNENKLHYVHAIADYKLNRQIIPFSNAFYRGLSDLISPSWLSLFNANEFNQLLSGGSQDFDVDDLRNNSKYTGGYTESSRTIKLFWEVIKGFKPTERCLLLKFVTSCSRAPLLGFKYLQPSFTIHKVPCDVTLWATIGGQDVDRLPSASTCYNTLKLPTYKRSSTLRSKLLYAISSNTGFELS
The following text describes a protein:
Function:
Protease that degrades several proteins of the host immune system. Cleaves P-selectin glycoprotein ligand-1 (PSGL-1), leading to its functional inhibition; PSGL-1 is a leukocyte cell-surface receptor essential for leukocyte recruitment to the site of infection. Next to PSGL-1, targets host CD43 and CD44 that are also involved in leukocyte homing. Thus, prevents neutrophil extravasation and thereby protects P.aeruginosa from neutrophil attack. Is also able to inhibit the decay accelerating factor (CD55), but not the cell-surface receptors CD46 and CD31.
Subcellular Localization:
Secreted.
Sequence:
MSLSTTAFPSLQGENMSRSPIPRHRALLAGFCLAGALSAQAATQEEILDAALVSGDSSQLTDSHLVALRLQQQVERIRQTRTQLLDGLYQNLSQAYDPGAASMWVLPANPDNTLPFLIGDKGRVLASLSLEAGGRGLAYGTNVLTQLSGTNAAHAPLLKRAVQWLVNGDPGAATAKDFKVSVVGVDKTAALNGLKSAGLQPADAACNALTDASCASTSKLLVLGNGASAASLSATVRARLQAGLPILFVHTNGWNQSSTGQQILAGLGLQEGPYGGNYWDKDRVPSSRTRTRSVELGGAYGQDPALVQQIVDGSWRTDYDWSKCTSYVGRTTCDDVPGLSDFSKRVDVLKGALDAYNQKAQNLFALPGTTSLRLWLLWADAVRQNIRYPMDKAADTARFQETFVADAIVGYVREAGAAQKELGSYAGQRQQSMPVSGSEETLTLTLPSAQGFTAIGRMAAPGKRLSIRIEDAGQASLAVGLNTQRIGSTRLWNTRQYDRPRFLKSPDIKLQANQSVALVSPYGGLLQLVYSGATPGQTVTVKVTGAASQPFLDIQPGEDSSQAIADFIQALDADKADWLEIRSGSVEVHAKVEKVRGSIDKDYGGDVQRFIRELNEVFIDDAYTLAGFAIPNQAKTPAIQQECAARGWDCDSETLHKLPGTQHINVDQYAQCGGGCSGNPYDQTWGLNPRGWGESHELGHNLQVNRLKVYGGRSGEISNQIFPLHKDWRVLREFGQNLDDTRVNYRNAYNLIVAGRAEADPLAGVYKRLWEDPGTYALNGERMAFYTQWVHYWADLKNDPLQGWDIWTLLYLHQRQVDKSDWDANKAALGYGTYAQRPGNSGDASSTDGNDNLLLGLSWLTQRDQRPTFALWGIRTSAAAQAQVAAYGFAEQPAFFYANNRTNEYSTVKLLDMSQGSPAWPFP
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MTVPIIRDIDTARAGILRRMPLDDDAATTTAVAGIIAGVRQRGDAALREYTQRFDGVDRATLEIPRERWAAAAADLDPALRHALLLAIGEIRRFHERQLRNSWVEFSVEGALGQLVRPLDRVGLYVPGGAAPLPSSLIHAAVPARVAGVREIVVCSPPQRSTGEPAEVVMAAAHLAGVDRLFAVGGAQAIAALAYGTESVPRVETIAGPGNRYVIQAMRLVYGTVGIVSLPGPTETLIIADHTASPRAVAADLLAQAEHVEASAILLTPDPVLAEQVQVEVERQLATLPSPNAQAARDAVTRRGGIVIVPDLATAFMLANDYGPEHLCLLVADPWSYVGMVRNAGGIFLGEESFEVLGDYVAGPSHIMPTEGTARYASPVNVDSFRKIISLVGLNRSGLNRIGPAAMRLAEAEGLVAHAAAVKVRFESADTDGRE
The following text describes a protein:
Function:
Catalyzes the first step in a degradation pathway of oxalate to CO(2) to protect the cell against the harmful effects of oxalate derived from endogenous processes or an environmental sources.
Subcellular Localization:
Peroxisome matrix. Peroxisome membrane; Peripheral membrane protein.
Domain:
The FACS motif is required for catalytic activity and substrate specificity.
Sequence:
MSFTTLYSAIQGDASARALVAPSLNAELSFSELRIAIMDLQRQIASLGIKVGDPVNIAIPNGLEFVVAFYAVSWQRAICGPLNSNYKQSEFEFYIDDLKSKLVIVPEGSVAANTPAVRAAKKLSVAVAELAWCPKSRLVRIVHFEGAKINAPQPLGLPQPDDVMLVLHTSGTTGRPKVVPLTHKNLCRSIHNITTSYRLDPRDTSYVVMPLFHVHGLLCGLLSTLASGGCAVVPPKFSAHSFWKEFIQYGATWYTAVPTIHQILLRTPPPKPLPRIRFIRSCSSPLAPPVLSKLEATFRAPVLEAYAMTEASHQMTTNPLPPLVHKPHSVGKPFGVELKILDQKGNEMPQGKEGEICVRGINVTKGYLNNPAANKSSFTKDRFFRTGDEGKLDKDGYVFITGRIKELVNRGGEKISPAEIDAVLMQHPDVSEAVCFAVPDEKYGQDIQAAINPVAGKTVTPKQLHDYLEQKVAAFKIPKKFYFTDRIPKTATGKVQRRLVCDAFFNHSKAKL
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Subcellular Localization:
Nucleus.
Sequence:
MSSRKPGSQSHGQQSAEEDNFKKPTRSNTGASSGKKAAENFLASGSVRKTRKNKQRTPGNRYGGSTSKAPQTPGKERAWADLTVESEDAFKNRMEVKVKMPEESKPWLVGDWNLQNVDAILKEYANCKTSQGNAVNEIVTRIKEYFDVMLGTQLLYKFERPLYAEILLAHPDAPVLFVRIGEMLAYISLDEKSLALLLGHLHDFLKYLAKNSASLFTGGDYKVASAKYHHKALCWSTDHSLLFA
The following text describes a protein:
Function:
Catalyzes a reversible transamination reaction between pyridoxamine and pyruvate to form pyridoxal and L-alanine.
Sequence:
MMRYPEHADPVITLTAGPVNAYPEVLRGLGRTVLYDYDPAFQLLYEKVVDKAQKAMRLSNKPVILHGEPVLGLEAAAASLISPDDVVLNLASGVYGKGFGYWAKRYSPHLLEIEVPYNEAIDPQAVADMLKAHPEITVVSVCHHDTPSGTINPIDAIGALVSAHGAYLIVDAVSSFGGMKTHPEDCKADIYVTGPNKCLGAPPGLTMMGVSERAWAKMKANPLAPRASMLSIVDWENAWSRDKPFPFTPSVSEINGLDVALDLYLNEGPEAVWARHALTAKAMRAGVTAMGLSVWAASDSIASPTTTAVRTPDGVDEKALRQAARARYGVVFSSGRGETLGKLTRIGHMGPTAQPIYAIAALTALGGAMNAAGRKLAIGKGIEAALAVIDADA
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis (By similarity). Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Chromosome. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2 (By similarity).
Domain:
The JmjC domain mediates demethylation activity and is required for satellite silencing; The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated (By similarity). It is essential for its ability to repress the transcriptional activator activity of CLOCK-BMAL1 heterodimer (By similarity); The F-box domain mediates interaction with UBB.
Sequence:
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQWPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLISVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKDFQKESLSMDMELNELESGNGDEEGVDREARRMNNKRSVLTSPVANGVNLDYDGLGKACRSLPSLKKTLSGDSSSDSTRGSHNGQVWDPQCSPKKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELASSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSDKAQKRKIEESDEEAVQAKVLRPLRSCEEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRPNPRVLMQHCPARNPQHGDEEGLGGEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRKELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPTDKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLFFLRRIANVTLIDLRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS
The following text describes a protein:
Function:
Transcriptional regulator involved in the specification of floral identity. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in the external flower organs in association with APETALA2 and other repressors. Is required to maintain floral meristem identity in concert with AGAMOUS. Also interacts with APETALA2 to ensure the normal development of ovule.
Miscellaneous:
MISCELLANEOUS: Mutations in the SAP gene result in the ectopic expression of AGAMOUS, leading to partial homeotic transformation of the external floral organs. Mutations affect equally ovule development and cause floral sterility.
Subcellular Localization:
Nucleus.
Sequence:
MSTSSSSSDNGAGGSGGVFEAPSPSRPRRGANDVWPEPFLESLAVQVAVNASTSAGLLAAAPALANVFRVCTTWHAVSRSDHLWQLLSRQVWARTHLMHDTWRDEFIYRHRTARNFRTRTHTYFTLQFDPSDVDEPDSLSCRCLTLSDLYLAAGFADGTVRLFLLNNRLHVRTLRPPLRDRFGRFSRAVSGIVISDSRLTFATMDGDIHVAEIDGVGHTRTAYAGDIVNDGALVDFTGCGRWWVGLFAGVPGRAFHIWDCNSEETTFVGGTLTDPEAVMGWHTLTELTTSLGRLRISGNETAVACTRWRIMVIDLRNQGVIIGEDEEQRRGLIVTGFDANDEAYVRLDSRGNASVRRVNTQQTVCEFRVSGAAQRRVMGCVNRLHALMCAGGIMRVWEVERGEYLYSIRERVGEVDAIVADDRHVAVASASSTAQSIIHLWDFGAL
The following text describes a protein:
Function:
Specifically hydrolyzes beta-1,3-galactan in an endo-fashion. Requires at least 3 contiguous beta-1,3-residues.
Sequence:
MKLFVVLACLAAPGTFPFVDAATVIPANSFSSFSTYWNNFYPWGTDHNGSGRMASANIIVASNTLSLIATPTSNPSPPTSTSNPKPAIHYASGAIHAKEHITVTAANAYTVSGEFSAPTAVGTWPAFWLTAVSGWPPEVDIGEWKGTADNWFNTFNTSSVVKSTLVDWPTDLSFHSVKAVLTAQSNNKDVKIDFYMDNKFIVTQYGSGFVGKAMYLIINLQMEGSSGSPGPSGRTVYKARNVQVTRTGN