lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MHLWLELVSVLFSLFVERRKRFKTLLEAHNIPETSALMSAQAHRSHMFPSTAAAHTSKLSDAKAVNKAEGTTDKEYVEEHGYLSSDPEEYFEADLFVGARAESMAEDLARVQAANQARGLSESDDFSEGDAEDCLAGQTIMSVEDIQRRREAHLVKLRHLYHQKMQRLQQQLSLKRLAYEKDADELRSSISRVQAELDADATAQLRAQGMLEPMDATPDGEEEDEDADEDGTIPIPAHRQALAMRVPRELDLDELDTEPISLVPTRQDAALLVRKLRTLPTPSGSHAESPKPETKTETSSPTETMDLTRPQAFRCIFEARASSEATDGAVERCPAIALPFSQYCRQHILKDEKQQLYVPDMPGRPLLVNA
The following text describes a protein:
Function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate. The enzyme from chilling-resistant plants discriminates against non-fluid palmitic acid and selects oleic acid whereas the enzyme from sensitive plants accepts both fatty acids.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MLSFSAAPSVCGTFPRLRVCSTSLSSTTSKVSPISYSFSRYRGLGVRRCTCTFYSSSKVRSMAELVEDKEPMGKRGLPGNAAVLASDSGAEKEVSHSRTFLDVRSEEELLLGIRKEKESGRLPSNIAAGMEELYQNYRNAVLKSGDPRADEIIISNMGVAFDRILLDIEDPFIFSPHHRAIREPFDYFMFGQNYIRPLIDFRRSYVGNISIFHDVEEKLLQGHNVVLISNHQTEADPAVIALLLEKTNPHIAENLTYVAGDRVVTDPLCKPFSMGRNLFCVYSKKHMYDVPELAEMKRRANTQSLKEMALLLRGGSRIIWIAPSGGRDRPDPVSKEWYPAPFDVSSVDNMRRLVDHSGIPGHIYPLALICHDLMPPPPQVEKEIGERREISFHGVGLSIASEINFSQVATHHEDSEEARMVFSQSLYSSVTEQYNVLNSAIHQDQGLDASIATVSLSQPWQ
The following text describes a protein:
Function:
Component of the DZIP1-Fam92-Cby complex which promotes ciliogenesis in sensory neurons and spermatocytes by acting downstream of Cep290 to initiate early ciliary membrane formation and thus transition zone (TZ) assembly. During spermatogenesis, also regulates distal elongation of the basal-body and their docking (anchoring) to the plasma membrane and as a consequence, regulates the initiation and proper elongation of axonemal microtubules. Within the complex, required to recruit or stabilize Rab8, Fam92 and Cby at the distal basal body of cilia to promote early ciliary membrane formation and initiate TZ assembly. Also acts with Fam92 to restrict Cep290 localization to the proximal part of the TZ. May also be involved in recruitment or stabilization of Mks1 at the TZ.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone (TZ) in type I sensory neurons and spermatocytes. In spermatocytes, localizes along the TZ membranes. Localizes at the centriolar distal ends of early spermatocytes and in elongating spermatids, when the TZ migrates away from the basal body, localizes at the ring centriole. In sensory neurons, localizes between the transition fiber and TZ core components.
Sequence:
MGFKGKYPQMVRETGFKLRQYRDGPLDWRLMGSYETERILREQNFELVDKALTHLSEAPLGTVLETHILDSGIAKYFVMSQYAIQYLMCCRTYLDECVTDLKEAHTTAQEEIATLRKSLSESNNEVVQLHKRITQIEAIREVVYPCHLCTKNFISNEALNVHIGRKHRVASPPSLTSATGKEKDRDKATDVHLINTIKMELEIKQLKERLNAAERNIKERSTGSKRVSPRQEQRHVGIQSNLAEPKEKDEDSGEARQSEASERKEQLTGLAERLSNFEEWQTQLKQSNEQFIQDINKRLEGLSHALEQSKQASASTPPLEDRVATPCLEDLERILTEKVAEIGKVSAHRLEEVVYHLEEGYKEKLGALERELKQLSVQKVQPEPVQTVPVASKIPKPVVRKEETNIDRIRKQVESEFLKQKHDDDTYSIEEAPRKGSEKPFPQLVTQVQVVEKEQPSAGSSDSNPTYTKSPREPAPNKQETKEATDVSDSLSQEETENEEERSLTEEEGTDVPTSGSEAAREDPTPKTIKPSGRIIKSPQKPLTRKDARKMVNRKLMSHGFDMKSKGISHNSLKRVNSELTEHRNKLKLQHPHFYATRNRIRKFVEKLCSAKFSERAEMLLKHKSPLKPMEVPGKGIPRSAISEKSEEDIASSQGEEQTDEQTDSSEQQTRSPSPQRLVSRDFKARLEEILVKPAATIRGASKSSLSSRPVPLPRKRVMFNTTEDGKSFNDSDDNLK
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MHSIANSSAPVSRSVRDMPNSGSDSDDDDDFVPDAEPSHTAVVRSGLSKQGKDAVVATDDPSDSDSDSDADGAHSETQDKPAGASVRAAEQIDADELEALRKEREELVAAAGGEQRLGKRRRLAHVSESGADNQVTNDNEVQALKAKAAAEWEAIKASESGSSMNEQVTQSTATGDYASATTLASTARQEMVSIPTTYKFAGELHTSMRLLPRSHPDALKYLSSQIASPTSTTSSAPAPSASASAPLPTSPASTSTSSSPSRPQPARPTPRRKKPSSLSALSAAATTKPTKLNTLEKSKLDWDTYKSDHSQLSQQELDELEHQTKRGGKGLGDMKGYLDRSDFLDRVKNRTAQP
The following text describes a protein:
Function:
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAKEELYSQIIPRKNRQHRAGTIKHGSSLEILLSMGFPKARAQKALASTGGRSVQAACDWLFSHVDDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQMCGRNKAHNIFPHITLCQFFMCEDSKVDALCEALQTTVSHWKSRFPNPLPLELYVSTNFIGLFVKEECAEVLKKFAADFAADALVKTEVRVEPHKKQLHVTLAYHFLDSHLPTLEKLAHSIDINLGCDWVAAIFSRDIRFVNHETLQVLYPYSPQNDDELELVPGDYIFMSPVEQSSTSEGWIYGSSLATGCSGLLPENYITKADECGTWIFHGSYSLLNTSLSATCSLEDRVMEKRQQEDPGMGDTSALTIICQPMQPLRVNSQTEPGAKKRCLFVCRHGERMDVVFGKYWLSQCFDTKGKYVRTNLNMLPSLPQRSGGYREYEKDSPITVFGCTQAKLVGEALLESNTAVDFVYCSPSLRCVQTAQNILKGLKQENKGKIRIEPGLFEWTKWVSGNTLPSWISPTELAAANLSVDTTYRPHIPVSKLVVSETYDTYMSRSFQVTKDILSECKGKGKNVLIVAHASSLDACTRQLQGLTSQNSKDFVQVVRKIPYLGFCCCEELGDTGLWQLTDPPILPLTHGPTGGFNWRETLLQE
The following text describes a protein:
Function:
Required for both pre-rRNA processing and heterochromatic gene silencing.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MDMKVVPWRLKEDFLYLMSCFYNEGQEGIPDLAALFRGVEIIQAWSTRGRIPHSVESTSQLVSSLISNDRSQKLALAVSISRFVSGLLDPIQQSQYAIPMAVLAKSIDLPTYFVELRHAITHEELPSLPVLRQAAQRALSWLYDHYWNPAATAESEDTYDYTETNELHKFEIKRKVKDLLKQWRSWRKVNVSANMFLPVEEHDYIQQFEALVQELVTTANLRLPYIPASFVDDEKDLDFAIETTNLDIVVSCFLEKRVLIPSRTMPISFFPKLKNVWLPLLQSIASKHSFFLPALFTTLWSEILEISQTVDSLVFLDLKEKEELTDKESAGCYLAKWYAYLMREAYTGQPWTSTLSVTQTDLASVLEICLQRSDPFTKIIIDELSILDKELENKFSPLFQYRSDMFDSRILDEQEFEDITLEQMKTELNKFSVRLNNIEAQADSSTMEFQGHVWYKPSVEPSPIGQIIES
The following text describes a protein:
Function:
Acts as a methyl group carrier between MtmB and MtbA.
Sequence:
MANQEIFDKLRDAIVNQNVAGTPELCKEALAAGVPALDIITKGLSVGMKIVGDKFEAAEIFLPQIMMSGKAMSNAMEVLTPELEKNKKEGEEAGLAITFVAEGDIHDIGHRLVTTMLGANGFQIVDLGVDVLNENVVEEAAKHKGEKVLLVGSALMTTSMLGQKDLMDRLNEEKLRDSVKCMFGGAPVSDKWIEEIGADATAENAAEAAKVALEVMK
The following text describes a protein:
Function:
Fructose and glucose phosphorylating enzyme.
Miscellaneous:
MISCELLANEOUS: Expression may pollen-specific.
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein.
Sequence:
MEGRAAGWVRVAAVGWAVAACAVAAGMVARRGAARVRWNRAVAVVRDLEERCATPAELLQRVVNSLAIEMFAGLASDGGSKVRMLLTCVDALPDGSEEGISYAIDLGGTSFRVLKVELGAGSTIINRKVEHQPIPENLTKGTSDDLFNFIASALKNFIEREGGEVEGRALGFTFSFPVRQTSISSGTLIRWTKEFSIEEAVGKDVAQCLNEALARNGLNMKVNVLVNNTVGTLALGHYYDDDTVAAVIIGAGTNACYIERNDAIIKSLGRVTNSERTVVNVEWGSFRPPQIELTPYDICFNNETWNYYDQGFEKMISGVYLGEIARLVFQKMAEESDIFGTAVDGLSTPFVLSTPNLAAIREDDSPDLREVGKILEEHLKLPDVPLKTRKLVARVSDIITRRAARLAAAAIVAILQKIGCDGTLCGSTQVRTMRGVRRRTVVAIEGGLFEGYSVFREYLNEALVEILGEEIAATVSLRVMEEGSGTGAALLAAAYSSARQKNSE
The following text describes a protein:
Function:
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections.
Sequence:
MPAPGALILLAAVSASGCLASPAHPDGFALGRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQAPSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN
The following text describes a protein:
Function:
Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. Note=In cardiac muscles localizes to the sarcomeric M line. Is targeted to lysosomes for degradation (By similarity).
Domain:
The PB1 domain mediates interaction with SQSTM1.
Sequence:
MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGCHVVDEVLPQTVVEKQATARTGKKPLAHYSSLVRVLGSDMKTTEEPTAEARSPVPCDTDKPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPPFSSSPSEVSMPISEEETLFLPENQFSWHIACSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYSHDTNHILLKFRRPVVISSEPFFYSKYPTPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHIGVVSVEFIAPTLEGTYTLHWRLSHKGQQFGPRVWCSIIVDPFPSSESPVNLERDGISSSKADDFTCEQEEAFLLAEEEIPLGEVTKQTEGTGSSAPQKTQHAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPRMSPLPHDSPLIEKPGLGRIQEESEGAGLKASPDSTVLTKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEEQQPLMLPGFCRKDSSLKFALPEEGPHGDEREEIVHIAEEEAIEEEDVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGQEPAEARERLPERESQPKEQSISDILTTSQHLDTVPLVPEVAGLPAALSRSAPCGQYEAPRVDSPVTIQEVLPVPDHVRGEPRGSTGLANSRQKSCDHSRHHNGSSIAGGLVKGALSVAASAYKALFSGPPVTAQPVISEDQTAALMAHLFEMGFCDRQLNLRLLRKHNHNILQVVTELLQVNNNDWYSHRY
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRNKEKAQSSLNRFYQSQSSAPINYHYHQRPKNIHSITQLSQAEGWRRSIIGEISKQLTEINDFEISDIKVRELNDQLNELFNEKRRWEYHIRDKLHGNDYIRHNGNTKNDLINTGIRVNNSDKGKYYRYFGRAKDLPEVKLMIEENKKNRKNHKRDDIDDSDQSKRRRKVDQYKSTDNSIDMNYYGFYDEEEDEYLDDSEAQLGDPLVVYEEKRTKELNDAEIQQQDTENLEQIRMSFNDIPTNEVVTKWLVNKRREQLLSKFR
The following text describes a protein:
Function:
Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Also seems to be involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLLSSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPLGDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHDAVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLEGKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKASKVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGKGTQIEVKVPIFPEEKGENERDSSIID
The following text describes a protein:
Function:
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MEVTGLSAPTVTVFISSSLNSFRSQKRYSRSLTVAEFKDKLQLVVGSPASCMELELYGPDDKFYVKLDQEDALLGSYPVDDGCRIHVIDHSGARLGEYEDMSKVEKYKISQEAYDQRQNSVRSFLKRNKLGRYNEEERAQREAESSQRLIEEEAQASAIPVGSRCEVRAPGQPPRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPSVVTVGDFPEEDYGLDEM
The following text describes a protein:
Function:
Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQLDTSTWFITIISSMITLFILFQLKVSSQTFPLAPSPKSLTTMKVKTPWELKWTKIYLPHSLPQQ
The following text describes a protein:
Function:
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
Miscellaneous:
MISCELLANEOUS: Was named 'Tectonic' after the Greek word for builder.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Secreted. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Despite the presence of a signal sequence, the full-length protein might not be secreted.
Sequence:
MGSRGLPPLLLVLLNCYTSSSTQVIAIPAAATPAVTKEDLNSTKATPTTLQPSLSPRTPGTPRAPERSGPRPTPVTDVAALCVCDLLPAQCDVNCCCDPDCSPADFSIFSACSVPVVTGDRQFCSQKAAFYSMNLTADPPHRDFKLIDQINPSVFCIHISNYKPALSFANPEVPDENNFDRLMQTSGGFTLSAESAVPSTAASDGPQPTKYEYGAPLQTAGASSGSFLKLPSPLTSSLCADQNPAAFLVSQAFECSRRVDIEQCEGMEALSMAHYSSPAILRVPNSMTQVSIKIQSVMYRSLNHTLTQLEGHGVLRPSLVSTGQDRLCSNVVLQVKYSLLYTATGQIHEAGLSLVLGTLSSAVSLLQQKFEIHFIQHGTKPVPLSGNPGYRVGLPLAAGFQPQKGSGIIQTTNRQGQFTILRSTSQQDCLASEGLRTPVLFGYNVQSGCQLRLTGTIPCGLLAQKVQDLLRGQAFPDYVAAFGNSRAQDVQDWVPVHFVTYSSNMKGSCQLPVALAIEVKWTKYGSLLNPQARIVNVTAQLVSVPEPLPGPERTVVISTAVTFVDVSAPAEAGFRAPPTINARLPFSFFFPFV
The following text describes a protein:
Function:
Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis.
Miscellaneous:
MISCELLANEOUS: Present with 1560 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus. Note=Translocates from mitochondrion to the nucleus upon apoptosis induction.
Sequence:
MTINTKNIVVVGAGVFGVSVANHLYRELGGTYAIKLVTASNYVYFLPSAVRLTVSKDYTKSILPLKNVLDSGIEVIKDTAASFDDKEVVLGSDRAIKFDILVLATGSKWADPIGSTYTFGDNYKEYFEREASRISDADHILFLGGGFVNCELAGELLFKYLEEIRSGKKRISIIHNSDKLLPDSGLYNDTLRKNVTDYLSKNGITLYLNTVGASLDTSPKRIFLGEGSSKYIDADLIYRGVGISPNVPVNSISDLCDKKGFIQVEKNFRVKAVEAGNVFAIGDVTNFRYHGLVKRDNWVDVLTRNVISSLQEGTEASLVDADCLETGHAPSGVSLGPNAGFGQFPLPLLGTINIPSFLISRAKSKNLFSDKMEPLFKK
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKFIESELILLKKEVDEMWTLVYNQLDRAGEAVMTLDKELAQQVMVRERRVNAFELKIDSDIEDIIALYNPVAIDLRFVLAMLKINTNLERLGDFAEGIARFVIRCKEPVLDADLLARLRLGEMQAEVLSMLELAKRALNEENIEMATAVFGKDNLLDDINAEATGILADYIREHPETAHTCVDLVGVFRKLERSGDHITNIAEEIVFFIDAKVLKHSGKVDENYPKS
The following text describes a protein:
Function:
Binds flavin derivatives, such as lumichrome, riboflavin, FMN, and FAD. May act as a flavin storage protein. Appears to lack proteolytic or chaperone activities.
Sequence:
MAKKVAVLAVNPVNGCGLFQYLEAFFENGISYKVFAVSDTKEIKTNSGMVLIVDDVIANLKGHEDEFDALVFSCGDAVPVFQQYANQPYNVDLMEVIKTFGEKGKMMIGHCAGAMMFDFTGITKGKKVAVHPLAKPAIQNGIATDEKSEIDGNFFTAQDENTIWTMLPKVIEALK
The following text describes a protein:
Function:
May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.
Subcellular Localization:
Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A- sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes (By similarity).
Sequence:
MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPLKGGFPAASQGANPSPGTPRTSHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTTRPARANRADDASMTLVEHLIELRSRLIKSGIAVLIGMVLGFVAVWPQGPIKLIDILILTFAPINDRFAPIQSVGTTEQFTSYMKVALLVGVILAMPVIVYQILAFIIPGLTDSERRLIYRALPFVTLFFLAGIAFGWFVTTPVALQFLIGFSDSPLIQTQPTLSDFLETVSMLLLINGIVFELPIIIYVLAYLNVTTARQLAGYRRYALVIVIIIAAFITPTGDPVNLMLLALPMYLLYEVGIILARFVPNAKPKTAA
The following text describes a protein:
Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Subcellular Localization:
Nucleus.
Sequence:
MNIETLLEAAKYVESGGALAIATAAEHSFTRGKDEVDNGDPKGASSYTPSILEKQLTGSPPPPKRARTKSPGPRYSETQHLLPPASQHVIPPPTSQAPITIATSIPVSSSSSIIQHAPRYPATTPPVSYHLYTHIPPQHLQQHHPVHQQQQQQQHHPRPSQQHPQLLPQHVQQHHFQALTHHQQAENQQPQRYVAASVANAVLSTQPPAPPPTHPPPVPPHPLLSPPPASSAGTSPRVVGPSQAMDLLQLAESQGHKYTTLNNVTSPRARSSPGSHHDNISPRLVHQIVSHNQWVAGERPGSPKQSPGHPKASGESDSNDSANDGSGKDKRAGIREVHNKLEKNRRAHLKDCFENLRNTVPNMEDKKAKTSNLSILRGALRFIQVLTRKERELEHELDRLVRQKIEAQQRLDLLKIKNGLTIGKPIKLPTLTGREEEEIEEDDDDDEEERLVVVEDKDVDVTVDDEIKNEVEDDQVSTSTASEAEEEERKSRAQSRSQSPLHQPVSSSHLSYSLPGVSYQQAFASFQGAIKETPPYTHAASRPVGLSRSANEAMLRFTTMRDAQPPQGSDPLRPKQKLPEAILPRHGSAPSLGTSAIPPQRTTYMQMTQDNVSSVLHSVANQISPVTRIETPIVVSQSSGALAGSVTRQTVSQLLGKQPVVRQPVRRQLSVSQLPVIQHPLQTPHHLLPRIMNTNPSLRLGFNPTTQGVIGPAKPVVTVGINSLLAQPSVIQTTSTHRTVISNGSGTTVPDPSTVTFTAKPTTPSVITASPFTTPIDTSPLITSVLGTSTAGVSRSTSLMTASVITQTLPVMSHTGHNQFIPPIALQSPANAGASLLFHPSSYIGLPHSMLPQPFLGSFAATRPSHIQLATSTQVSPSFAASQPLVHPSTQPIDSANLLALAQALPKQMPPAQFPSALSIGSLASPGTLLSTNLSAVNHGSFTTVSSTPISAAPAVKNAMSAAAPASKKSKSSASGSSGGKGSRSKHGKSLNGKTEIQITTSKIAETMATLANTQVIANNGHSTSTVNNRSSQQSVVVKL
The following text describes a protein:
Function:
Involved in the biosynthesis of rosmarinic acid, a compound with antiviral, antimicrobial and anti-inflammatory activities. Can use 4-coumaroyl- and caffeoyl-CoA as hydroxycinnamoyl donors and 4-Hydroxyphenyllactate and 3.4-Dihydroxyphenyllactate, but not shikimate or quinate, as hydroxycinnamoyl acceptors. Can also putatively catalyze amide formation with D-amino acids as acceptors.
Sequence:
MKIEVKDSTMIKPSAETPGGSLWLSNLDLLSPANYHTLSVHFYSHDGSDNFFDAAGLKESLSRALVEFYPYAGRLKLNGNRLEIDCNNEGLLLVEAECDGALDELGDFAPRPELNLIPKVDYSRGISTYPLMVFQLTRFKCGGVALGVANEHHLSDGVAALHFINTWAHLSRGAPAPTPLPHFDRSSLSARNPPQPQFSHAEYQPPPTLENPLPHTDIAHSRFKLTRDQLNSLKSKFKTAPADGGAGKSYSTFEVLAGHIWRSVCIARGLPEGQETKLHIPFDGRGRLQLPPGFFGNAIFFATPIATCGEIESNSLNYAVRRVSDGVSRLDEDYLRSSIDFLELQEDISKLAQGAHSFRCPNLWVISWVWLPIYEPDFGWGKAVYMGPWAAPFEGKSYLLPNPEKDGSLFVSITLHKQHMERFEKLFYEI
The following text describes a protein:
Function:
Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Also plays a critical role in virion morphogenesis.
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network.
Sequence:
MPRSPLIVAVVAAALFAIVRGRDPLLDAMRREGAMDFWSAGCYARGVPLSEPPQALVVFYVALTAVMVAVALYAYGLCFRLMGASGPNKKESRGRG