lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA target cleavage products that lack a 5'-cap structure. Antagonizes the negative feedback regulation on EIN3 by promoting EBF1 and EBF2 mRNA decay, which consequently allows the accumulation of EIN3 protein to trigger the ethylene response.
Subcellular Localization:
Cytoplasm.
Sequence:
MGVPAFYRWLADRYPKSISDVVEEEPTDGGRGDLIPVDITRPNPNGFEFDNLYLDMNGIIHPCFHPEGKPAPATYDDVFKSMFEYIDHLFTLVRPRKILYLAIDGVAPRAKMNQQRSRRFRAAKDAAEAEAEEERLRKDFEMEGQILSAKEKAETCDSNVITPGTPFMAILSVALQYYIQSRLNHNPGWRYVKVILSDSNVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIMLSLATHEVHFSILREVITYPGQQEKCFVCGQTGHFASDCPGKSGSNNAAADIPIHKKKYQFLNIWVLREYLQYELAIPDPPFMINFERIIDDFVFLCFFVGNDFLPHMPTLEIREGAINLLMHVYRKEFTAMGGYLTDSGEVLLDRVEHFIQAVAVNEDKIFQKRTRIKQSMDNNEEMKQRSRRDPSEVPPEPIDDKIKLGEPGYKERYYAEKFSTTNPEETEQIKQDMVLKYVEGLCWVCRYYYQGVCSWQWFYPYHYAPFASDLKNLPDLEITFFIGEPFKPFDQLMGTLPAASSNALPGEYRKLMTDPSSPILKFYPADFELDMNGKRFAWQGIAKLPFIEEKLLLAATRKLEETLTVEEQQRNSVMLDLLYVHPAHPLGQRILQYYHFYQHMPPHECLPWMIDPNSSQGMNGFLWFSERNGFQTRVDSPVNGLPCIEQNRALNVTYLCPAKHSHISEPPRGAIIPDKILTSVDIKPFPPLWHEDNSNRRRQARDRPQVVGAIAGPSLGEAAHRLIKNTLNMKSSTGAASGLIDPNGYYRNVPGNYSYGGVNRPRAPGPSPYRKAYDDDSSYYYGKYNNSTQGTFNNGPRYPYPSNGSQDYNRNYNSKIVAEQHNRGGLGAGMSGLSIEDNGRSKQLYSSYTEAANANLNPLPSPPTQWIGTQPGGNFVGGYYRDGVGYSETNGKSVKKVIYQAKTQPSHRGANL
The following text describes a protein:
Function:
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates (By similarity). Component of the BTR double Holliday Junction dissolution complex, which is involved in homologous recombination during meiotic double strand break in the germline (Probable). Plays a role in double strand break repair by positively regulating the accumulation of rad-51 at double strand breaks. Stabilizes and positively regulates the localization of the BTR double Holliday Junction dissolution complex components rmh-1, him-6 and top-3 at nuclear foci during meiotic recombination. Positively regulates meiotic recombination, chiasma formation, and chromosome segregation in meiosis. Positively regulates DNA crossover formation and positioning on chromosome arms (away from the chromosome center) during homologous recombination.
Subcellular Localization:
Nucleus. Note=Co-localizes with rmh-1 in nuclei foci during pachytene in meiotic prophase I. Localization at nuclear foci is dependent on rmh-1 during meiotic recombination.
Sequence:
MCDRDDCASIASRCTGETIICAFVESITPPKIRDKTGTYELKCPFAEGFTMEIGDLFLFHFVFDGSSEKCTRLTPIPKMLAMVYEKLLKDLRKAKKEGKMIISPTAN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPREVSWPMWAMFITATYALAGWSAYSCATSFDDPLSALFMASSGVHFVIWGNFLIVHYCLFVWAIIRVLFGQLTAIEYDHIFERLHVVLVTLASIVITMRKTYMAGHMTILFYTLCLVAHWVLRDRMDFVFQVHGTDSSLLGILCSRFMFSLLVLGMVDYKMLKFCVQNTNVDGKRHDLYLMLALSFAQLILDVLHVVLLTSLNLFEMVRSRRTRSANLVYEGGTTDDDADDEVFILEGKYIYETVFDLTITVLKVILDIIQEVFVPWSITVVYSIFVRSIKAGESFLLVYNYWKNNKKLYEKLSDVSEEQLDDTDSMCIICMDDMLPTTETTKMNRRAKMLPCGHMLHFGCLKSWMERSQTCPICRLSVFANDSNSHATTQAREQTPPDLLQERGIDEHIDVIGMQDMSVQSISLHEGTAVRRGTTGNCMNQAYDGGLLSHEERDQAGWVAFPIEFRADNKVFFNLNDSQGDRQWMASYTSYPRQNMVNSDDPDNASESHSRIPSPSLPGSLEGTSSQVDVTVSAKDAPANACFVIATSKLEQTKEVEHLKRKVEELESRVEELSKRIKTDQV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTHLPSSAVRDHMKWAGLLGCEAVLSSMALMQASSMAGQKKMMSPLGQGAAGAGQRDGGDRGAQSHMVLPTGLSCPPLLIRKEGEFHSSRLLDDKELRESEELQLKKKNRKSGTPCKVVVVDENGDCSLKLQKSFICEHCYRGFRSSYHLKRHVLTHTAWGAGEKPFACDVCDMRFIQRYHLERHKRTHSGEKPYQCERCQQSFSRSDRLLRHRRMCQGGGGAKVEAPSCLEPRSYAQDPNPPPTASWSPLTQTPPGRLAV
The following text describes a protein:
Function:
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
Subcellular Localization:
Cytoplasm.
Sequence:
MINKNDIVADVVTDYPKAADIFRSVGIDFCCGGQVSIEAAALEKKNVDLNELLQRLNDVEQTNTPGSLNPKFLNVSSLIQYIQSAYHEPLREEFKNLTPYVTKLSKVHGPNHPYLVELKETYDTFKNGMLEHMQKEDDVDFPKLIKYEQGEVVDDINTVIDDLVSDHIATGELLVKMSELTSSYEPPIEACGTWRLVYQRLKALEVLTHEHVHLENHVLFKKVS
The following text describes a protein:
Function:
Involved in membrane trafficking and vacuole development through membrane fusion at the vacuole. Required for membrane trafficking machinery and accumulation of flavonoids in the seed coat.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MWLSFLRPRDRFSLAELRYLTDQLRKIQIVNEANKDLVIEALRSIAEILTYGDQHDPLFFEFFMEKQVMGEFVRILRVSKTVTVSVQLLQTMSIMIQNLKSEQAIYYLFSNEYVNYLITYTFDFQHEELLSYYISFLRAVSGKLNKHTISLLLKTENDVVVSFPLYVEGIQFAFHEENMIRTAVRALTLNVYHVGDESVNDYVVSPPHTEYFSKLISFFQKQCMDLSAMVLNTLKSPSPDSGGKLFSAVDGIEDTLYYFSDVISAGIPDIGRLITDHILQHLTLPLLLPSLCSEAVNDISVDPVTSLYLLSCILRIVKIKDLANMTAATLFCPVKAFISSSLVKPNSSLAPEGLTYVNGHPDKGVTEEANQQCSSTAAGMSDDGNSHLCSEDTPKSIFNNSHMTFRETLLQYISEGDDVQAQGSLFVLATLLQTKELEESMLDAFGILPQRKQHKKLLLQSLVGEDTGEEQLFSPRNGSMRDGLSSELDWYLRRLEEQFGVCCSLPGAARCPRVHRHQVVDTLVTLLCRENISAETLWDGGWLLRQLLPYSEAEFNRKHLKMLNVSYEKCKNSLTREIKGIWPDLLIRVLLDEWRKCKRVIEAPSPQKEPKSVLLQLDRSSSNDNSVSESSFTAGERMCEVVKVFVLLHQLQIFSLGRSLPEQPPIYPPADRSETSRATRAGLDVSVPKPGTELKLVDAVPCRIAFERGKERDFSFLALSSGESGWIVLADPDNGIVRVTAPLAGCKPRIDEKHPRWLHLRIRPSTLPLLDPTKRGVYEKLKSKGLVDGRWILAFRDDESCHSAYSMVAGEIDLQCSEVERRLRPLFDLERNQLEDQ
The following text describes a protein:
Function:
Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear; May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MRPVSPVLFLTLLAVNAGNILPGAAEVENRGQKVWAREGSSALLPCYLSPRKHGKSRKHLSGRTSVLWKRHGASAPQELHVVLEVEYTGLRKTALPMRPRVSVLDSALRNGNFSLCINPVRSDDVGLYEAQVAYNTEILSCQVELGVVTVTLSPPLPVVENEPLLLSCNSSHQASLVETCWFHNGRPVLISGAFCSSHGALYILRPTVSDSGSWHCQLRYADNEIISATYNLQILGFDGPTNPVVYAAAGSAADLPCTLNYLPSASGIRVVKAHWSHFAGGHLQNWSILQNQSSRNFPLHLPVVGPGDAGRYCCAVTVGNKMLSRDMTLAVITVTPRIQGPVSEGSHLLLTCSLTNPQGHEYFQWKHLSSASAEKKLTVATSHNLKDSRVRTGPTLEIPQVSQKDVGIWECSVYGPEGRLGAVEYGLQITGAQVSGPPTIFSGQVTFGLMLTLFFLLMVCILALGLQKRARLPASFPALERIVAVTVPKEMEESQKETIQQTEC
The following text describes a protein:
Function:
Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7. May have a role in sialyl-lex-mediated transduction of apoptotic signals (By similarity). Involved in bone resorption.
Miscellaneous:
MISCELLANEOUS: Sialyl-lex is a carcinoma associated antigen.
Subcellular Localization:
Autolysosome membrane. Endosome membrane. Late endosome membrane. Lysosome membrane. Note=In case of infection colocalizes with Salmonella typhimurium sifA in proximity of Salmonella-containing vacuole (SCV).
Domain:
The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and LC3A/B/C.
Sequence:
MLSVENGLDPRAAIQVIKKKLVGSVKALQKQHVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAEAGGKRKKHTHQKALPQPVFWPLLKAITHRHIVSDLEHLVFINTDVGRCRAWLRLALNDGLMECYLKLLLQEPARLCEYYQPTALLRDAEEAEFLLSFLQGLTSLSFELSYKSAILNEWTLTPLSLSGLCPLSELDPLTTSGAELQRKESLDSISHSSGSEDIEVQHSGHKIRRNRKLTASSLSLDTASSSQLSCSLNSDSCLLQENGPKSPDHSEEPMSYDSDLGMANTDDPDRSLQEVLSEFSKAQVNSAPSSGPNQEPDTPMFQTPLSLHSLATSTHLHFEGSEELFPAHKSSGTSSGGHKHQLLPQETPDEKQLGTAQAGPAQSTSDQQPSSPVGGAAGQGSGPWKALEYGRVGPKLVVSSPTSPKGKSWISEDDFCRPPQEPALKSAAGLCTSPVQDTPESRAALHGPFSQGPRKSCSLGALDKACVPSQACGNAQPAPAPAPAPAPAPAPAPGVTQDHKNFCVVHRRQMGLSNPFRGLMKLGTVARRGAMGIWKEFFCELSPLEFRLYLSDEERTCVESCSLLRCEAVGPAHSDGRFELVFSGKKLALRASSQDEAEDWLDRVREALQKVRPQQEDEWVNIQYPDQAEDAPEAPPDSLPPYSTLLPEPAGAQGMQLDWTSAQVPEPDAIKESLLYLYADRTWVPYIFSLSLESLKCFRVRNNEKMLSDSHGVETIRDILPDTSLGGPAFFKIITAKAVLKLQAKNTEEATHWRDLVRKVLASYLESAEEAVTLGGSLDEKCQEVLKFATRENGFLLQYLVAIPTEKGLDSQGCFCAGCSRQIGFSFVRPKLCAFSGLYYCDFCHQDDASVIPARIIHNWDLTKRPVCRQALKFLAQIRAQPLINLQLVNASLYEHVERMHLIGRSREQLKLLGDYLGLCRSGALKELCKRLSHRNYLLESPHRFSVADLQQIAEGVYEGFLKALIEFASQHVYHCDLCTQRGFICQICHHQDIIFPFEFDTTVRCAECRTVFHQSCQAVVRKGCPRCARRRKYQEQNVVS
The following text describes a protein:
Function:
Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVENTTTKSVHTIVLDAGPILKNNPPLSTLLSRCEELVTTPSVVAEIRDPDARQRLETMYLPFLKQRTPSPKSFAVLSEFAKKTGDRAVLSRTDIEVLALAYELECERNGGDWRLRSVPGQKRVNGKPPVKPVEQQGGQQPEGTATTDEIAEDPAVKEVTEDLKATTLETKEDESNTEHPRGAEPEAAEDNQAADLAVQDSQDEDEAGEVEDGAASESDGGEWITPSNLKKRQARDEVGDATAASEVKVMQVATMTTDFACQNVLLQMNLNLLSTATLQRISHLKSFIKRCHACFSTTKDMNKQFCPRCGGDTLTRVSCTTDSSGQFKMHLKKNMQWNNRGNVFSVPKPVHGSASGKWKGGGGKGGWGTELIFAEDQKEYVRATAEQSRKLRRERDLMDEDYLPGILTGERNKQTGRIRVGAGRHVNSRKR
The following text describes a protein:
Function:
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.
Subcellular Localization:
Nucleus.
Sequence:
MSGGWGREMMDYGGGGGGPGGSGGGRGGGGMGTGDGRIYVGNLPANVREKDLEELFYKYGRIRDIELKSKRGLVPFAFVRFEDPRDAEDAVYGRNGYDYGQCRLRVEFPKPSRGRGGFGGGPRGRNGPPSRRSEFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGMGVVEFLRKEDMEYALRKLDDTKFRSHEGETSYIRVCPERSISYGYSRSRSGSRSRDSPYQSRGSPRYSSPFRPF
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MEIDDILASVDHTDISSPESTALDHQLLTRFWVAERSVPELLPWPARLMERMMERVRQQIETIEDLAAASSEPTSSTVNPNATLTLSILQTDLSRSQYLLRSLLRNRLSKLTKHSMHYLLLSSHNPPNPPPASGSSEAKYQTPEDSVPLPDPDNLPRSSPLSPSETTFLYTHQQLLAKHFGSSFLNSFPPQLRRLDDNAGGTSMVQGPDTREAVFVRCLADEVLLLAPPGPGEGDDGEEVYGGTMRMGDVWVVRWEAVKEAWERGDVEVL
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Sequence:
MNPDYGDCKFCLKLKDHSENRCEFSEVIAKCQEWVASLKGRMPEDVLIQCQTGSFMLSGNQTMVVIVGMEGSGKSSIISGLNGRGVILKNEEMHRDFKCKYVTLRTNEKKAMTFSFIEPRGVENMLTGLSIADCAIIVIDSTQGYPINNIVDSEDNIVDPASLAVSMGLKTLICCVNKMDVVGYSQTVYNQLRDGAITYFKSIGIEESNVTFVPVSAQTGDGLLDKSEEMAWYEGLTLIGQLHTLDRESRTSRRLRLVVDSTEVKGTVVLIRCRVHYGILLSGRRVVFCPGNWAVYVDKMRVGGLEVKYAWPGEAVELEVKGPVNEMMEQGCVGAAIIDDKLKVAMGIEVEILVTNSKVEVTTGLQGYLCSCHKASFPVIVSQIKESVDAATRIRNKDTPTSLKIGQIGVVSLTPLVEVVVETVSDYMSLGRIIFCKEEEEKKDVVAVGVVVDVDHTELPKLNMEQLNLGKPVRIK
The following text describes a protein:
Function:
Confers resistance to antitubercular drugs benzothiazinone (BTZ) and dinitrobenzamide (DNB). Inactivates BTZ and DNB by reducing an essential nitro group of these compounds to amino group or to hydroxyl amine, respectively, using NADH or NADPH as source of reducing equivalents; two electrons are transferred. Able to reduce the nitro group of bicyclic nitroimidazole PA-824, but not of quinone menadione, nitrofurazone, methyl-4-nitrobenzoate, 4-nitrobenzene methyl sulfonate or 4-nitroacetophenone.
Sequence:
MSVPTLPTGPTVDLAQAAERLIKGRRAVRAFRPDEVPEETMRAVFELAGHAPSNSNTQPWHVEVVSGAARDRLAEALVTAHAEERVTVDFPYREGLFQGVLQERRADFGSRLYAALGIARDQTDLLQGYNTESLRFYGAPHVAMLFAPNNTEARIAGDMGIYAQTLMLAMTAHGIASCPQALLSFYADTVRAELGVENRKLLMGISFGYADDTAAVNGVRIPRAGLSETTRFSR
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MMTDPIADMLTRIRNAVRVERPFVDIPASRVKRGLADVLKREGFIWDWKEEKLEEEPVGYLRLELKYGPNGERVIQSIRRISKPGRRLYSRSKELKPVLGGLGIRIISTSKGVISDREARRDKIGGEVLCEVS
The following text describes a protein:
Function:
This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD(+). The NMN adenylyltransferase domain also functions as the NAD and ATP sensor.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MLQFDYLKTAIKQKGCTLQQVAEASGMTKGYLSQLLNDKIKSPSAQKLEALHRFLGLEFPRREKKVGVVFGKFYPLHTGHIYLIQRACSQVDELHVILCHDEPRDRELFENSSMSQQPTVSDRLRWLLQTFKYQKNIHIHSFDEHGIEPYPHGWDVWSRGVKAFMNEKGIVPSFIYSSESQDAPRYREQLGIETILIDPQRSFMNISGRQIRRDPFRYWDYIPTEVKPFFVRTVAILGGESSGKSTLVNKLANIFNTTSAWEYGREYVFSHLGGDEMALQYSDYDKIALGQAQYVDFAVKYANKVAFIDTDFVTTQAFCKKYEGREHPFVQALIDEYRFDLVILLENNTPWVADGLRSLGSDRDRKSFQNLLEQMLRDNNIEYVHVESADYDARFLRCVELVQQLLAADPQRLARPSVLTDAR
The following text describes a protein:
Function:
Dynein-attachment factor required for cilia motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm.
Sequence:
MSNSRLSFEKLFKELCIAEEKEARYWRENDAKFRAVHQKVATYDEFRGIVQASHLKPLDKNDKINGKFYQPWNAISSEKSYTEENHYPVSSSNLHINDPDNKKNFFRLWKLSTSVEKYCFLTTSRKEHIKTIFSVDINCELLGEAVVELNNNYNNIDASKIFEVLSIFADASRFKLLLDFLSQPEKDSLKELFKKLETDLNSKNIFDLKNVYSI
The following text describes a protein:
Function:
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTEAGKLPLPLPPRLDWFVHTQMGQLAQDGVPEWFHGAISREDAENLLESQPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQKDPANVDYEDLFLYSNAVAEEAACPVSAPEEASPKPVLCHQSKERKPSAEMNRITTKEATSSCPPKSPLGETRQKLWRSLKMLPERGQRVRQQLKSHLATVNLSSLLDVRRSTVISGPGTGKGSQDHSGDPTSGDRGYTDPCVATSLKSPSQPQAPKDRKVPTRKAERSVSCIEVTPGDRSWHQMVVRALSSQESKPEHQGLAEPENDQLPEEYQQPPPFAPGYC
The following text describes a protein:
Function:
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MAEPGRLMGQTASNADPDDIDADGDYEMDDEYEQEQVAGAQISQLDGHSTDAEGSDVDAEGAVKIALRRPASSDEEDDYNDEEAVAHSSDAKTSDSEDESGAESEEEAPWQAESENGEEVEAARSDPNVCIYCNQDEENDPSPEYEEYLSCGVCGDNGYHLVPKLARDLLPSHRGVDPGGHSIFKEPHSSLTMPQTALTGFKGKRKASHEEEPVAQPSRGNRNKQRPSEASKSPVGGTSVNASSPALRPKSARSARSAITEAHDTEGEAQQTASDNDDEDDETRTRSRPRRSKMKRSNDKRPLAWIEEQQGLSLIMAFHLNNEKVQKIVTAKPKKKVLTIEQERQERRRERDRERRERNRRAAQAARESPELTHYPAVPIHYSTPFHGFSEKEDESKSKPYGGVLSEADADTSKTYPSQADRKRFEEARVKAEEEWKEKQDTLYAHLDVIKPSKQTATASKIKCVNFGGWEIDTWHAAPYPEEYSKNRVLYICEFCLKYMNSDYVAWRHKLKCPAKHPPGDEIYRDGKYSFFEVDGRKNPVYCQNLCLLAKLFLGSKTLYYDVEPFLFYVMTENDNYGCHFVGYFSKEKRPSSLNNVSCILVLPIHMRKGYGQYLIEFSYLLTRVERKTGSPEKPLSDMGLVSYRKYWRLVLCEELLQQKGPISISAISDRTGMTADDIVSALEGLRALVRDPVTKKYAFRLDTGYFKQYIEKCNAADNPKINPDCLLWTPYVMGRLGQYEDGPALQTVQQRDEVEEEEKPVPEEGVQMDAAAKQNGSTQDQDGGTGDEADPSVPALPAEDSVNGGSPAPGTPLANGSTIALAGSQMATSEPAIPPSRYEIFPPIPGQPASRRRPGRPFGTRRRTSTPNRARNTPLSIHTAPVSKIQLSPSRIAKGSPSNGALTPGTILRRTRSRLGESVTNGDDVEEGGAVKAVLTNGRRSTRSSASSLGSPRVGKDIKGKGKALPVEEEQDDPDADADGDYDEEADEGMDIDAEGEDDDDIIMAGA
The following text describes a protein:
Function:
G protein-coupled receptor (GPCR) that senses glucose and signals via the heterotrimeric G protein alpha subunit gpa2 to activate adenylate cyclase and PKA signaling, and suppress sexual development and gluconeogenesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLHLDYTFNVSDATSTSSIIIVSRRELANLRIMVIIASAISIVFSLIAIFWRWSRRRTIREQFHIALFSVLFIRSIVQMIHPCLALSDPFFWAPKHRCFTIGFFLLVLVRMTDYWIFINILHNALLVLFPHVDTERRGLYRFRHTVFTLSFVIPLTIGGLAFTNKRNTFVNLQTRCYLPYTPVRFMFGLNWSFDYALSIAIIALQTCMFISIRRKIKRFKKYSHQQTNVFDTLNVIDSYPTAPDQVALPPFPDTNSTLTYTPSNSQSIYSSQSQPSPYSRPLLSSVHPNLPPGSQSTPANLNQSGIHFEQDFRDSPNRTNGLEDHTSFKLSSPLTSDEDGASSVLAAYGNDMQDDPLLKQRKRILSQSKFLFAYPAIFIFMWILPQIQIIVILAQPLHCSGSCKRFAFVAVFADNFVAIFIALSDFIWICYRGYTYLKERDSSKSYWDQIKELTLKWWRGKFGEEK
The following text describes a protein:
Function:
Binds preferentially DNA with A/T-rich content.
Sequence:
MSAPHLSYGPKTAVFTNGYGSSTTTYPSPEASYEEIIQNPQFFWEKLQLFHSVFGTKFKIPVIGGSSLDLHRLFIEVTSRGGIEKIVSDRRWKEVMAVFKFGPTITNASFVLRKYYLSLLYHFEQVYYFHKKTPTIGPHDATNKVSHGSASGSVKNLFSARQKIEVGGEVTGTIDNRFDQGYLVTVDLGSEKLSGFLYHLPSDSPAPSHGTHNMYQLAIREPSPEPDTSGYDVFFTEHYIRLKPLYHGQESIIRKRIQVLWSTLTEEEKQIYQLQGLRGKER
The following text describes a protein:
Function:
Catalyzes the O-acetylation of peptidoglycan (PG), an important mechanism that appears to confer lysozyme resistance and contributes to pathogen persistence in the host.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLASIISILRVFVLLFNTPLFIFAFLPVGFLGYFILQAYAKNPLFPKLWLVLASLFFYAFWNVKYLPLLVGSIVFNYFVALKIHQTQPNAYKRLWLILGLIANVSLLGFFKYTDFFLTNFNLIWKSHFETLHLILPLAISFFTLQQIAYLMDTYKQNQIMQPKMRERVSENAPILLNPPTSFFSLSHFLDYALFVSFFPQLIAGPIVHHSEMMPQFKDKNNQYLNYRNIALGLFIFSIGLFKKVVIADNTAHFADFGFDKATSLSFIQAWMTSLSYSFQLYFDFSGYCDMAIGIGLFFNIKLPINFNSPYKALNIQDFWRRWHITLSRFLKEYLYIPLGGNRVKELIVYRNLILVFLIGGFWHGAGWTFIIWGLLHGIALSVHRAYSHATRKFHFTMPKILAWLITFNFINLAWVFFRAKNLESALKVLKGMVGLNGVSLCHLSKEASEFLNRVNDNMIMHTIMYASPTFKMCVLMIIISFCLKNSSHLYQSNQMDWIKTTSACLLLSIGFLFIFASSQSVFLYFNF
The following text describes a protein:
Function:
Rhodanese domain-containing protein required for anchoring ferredoxin--NADP reductase to the thylakoid membranes and sustaining efficient linear electron flow (LEF).
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MAATTTILSSAAPTPLTAPPRARARAPAARRRRLRARDILGAALGLANGGASAALAAPLSYEETLRLSTDSGGGGGGGGGGEFALPDLGLGGVLDFVAQNPLAAAAGVAAVALPLVLAQVLGGASKPYGVVSAAAAYRALVEEPGAQLVDIRPPGDARQSGAPDLREAKKKAAAVPYDGEDKNGFLKKLSLRFKDPENTTLVILDNLDIMQTRFDGNSELVAELVTANGYKAAFAVKDGAEGRRGWLDGTDGLPVTLGLAAATGLGILAYTEIETVLQFLGSAAIVQLVASKLIYAEDRKRTLKQIDDFFNKKVAPKELVDEIKEIGQALLPSTGTKSQPAITEAAPATAEAAPAAATATAAPPAAPVEETSTEAAPAEPTPLSPYTNYPDLKPPSSPSPLAPAEATKNESESESAATESAPAVNSAPVAEAAPEAAPPAAPRPLSPYPNYPDLKPPSSPSPSAP
The following text describes a protein:
Function:
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MFHSSAMVNSHRKPMFNIHRGFYCLAAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAIDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSVSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLNEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLQLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLLVNT
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSQRIGITASALTRVWHHVDVAADNRSLGRLASSIAITLMGKHKPTYTPNRDHGDYVVVTNCAHLKVTGNKLKEKTYWSHTTRPGTLRLVPMERMIDNKGYGEIIKRAVKGMIPKNKHRLVRMDRLKLFDGDDHPYKDNLIAFADENPDMRNKLAELEKNEKNRAELREKYLSHQQ
The following text describes a protein:
Function:
Involved in maintaining the structural and functional integrity of mitochondria. Activity is required for maintaining the subcellular distribution, shape and activity of mitochondria in neurons and as a consequence has an important role in the development and maintenance of dendritic arbors. Function may be particularly important in class IV dendritic arborization (da) neurons.
Subcellular Localization:
Mitochondrion. Note=Detected at the mitochondria cristae.
Sequence:
MVVAASTCRTETVFDYSWMNVVVAYWNRYPNPSSTHVLTEDTIQREVRDGKLFSRRLLSKTNPVPKWGARFYNNVPVKIVEDSVLDPVKKTFTTFTRNLGMTKIMKVDEIVVYSEQKDGSTLAVRRAYISSQVFGFSRAIRAFGIERFKANGNKASNGFNYVLRRMFPDSLVGGGHHQHAVTTTSPAGELPATTITVSTTNGSLNNQGALKSAAKVGYEFFKSHASKIAQLFSVKN