lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Sequence:
MASVAGDSAMEVVPALAEEAAAEATGPSCLVQLPGEVLEYILCSGSLTALDIGRVSSTCRRLREVCQSSGQVWKEQFRVRWPSLMKHYSPTDYVNWLEEYKVRQKAGLEARKIVASFSKRFFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKALTWKYYAKKILYYLRQQKILNNLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISFRDIQAQIHSIVELVCKTLRGINSRHPSLTFRAGESSMIMEIELQSQVLDAINYVLYDQLKFKGNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLRWCQGAEGATLDIFDYIYIDAFGKGKQLTVKECEYLIGQHVTAALYGVVNVKKVLQRMVGNLLSLGKREGIDQSYQLLRDSLDLYLAMYPDQVQLLLLQARLYFHLGIWPEKSFCLVLKVLDILQHIQTLDPGQHGAVGYLVQHTLEHIERKKEEVGVEVKLRSEEKHRDVCYSIGLVMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVEPQEISHPDVGRYFSEFTGTHYIPNAELEIRYPEDLEFVYETVQNIYSAKEDTAE
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MATQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEENTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MVWREQTCWCVTGEVVVWEQVVYKFEFSVAVTCSSWISLLSSSSPVPRITRQPPTNQPTPKPTTTHNIHQPNTCCSFAKGPMHTIAQRINAVSAVATTTIIFLVAGIALIGLFEKPVFEPARVEISDVEVLWGHDRRDHFDRRDREWTNFRFAVEADLRPIFRYNTKQIFVYLVADYSTPEFPSNEVVLWDRIIRNPRDAKINLSGARNKYAFKHIGGSFKDVNATYTLHYNLMPKVGALTWGIAGQTKSSVPFPPVNYRKPLNR
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Miscellaneous:
MISCELLANEOUS: Present with 2550 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=Enriched at crista junctions.
Sequence:
MSKLGPLARSVKWTLSVGVIGSVFYLYRYSNNGYFYDHDATWLKQDHQVQDLVDRKEVVPGETRNRKLVVTDDGTAWSRTMGESIKDIWNEQIRNSVDWIYSWGKN
The following text describes a protein:
Function:
Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo.
Subcellular Localization:
Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling.
Sequence:
MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELFRSGQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRFLMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRSDLYEYIVDFLTYCLDEELVWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKALVKYLEHLVIDKRLQKEEYHTHLAVLYLEEVLLQRASASGKGAEATETQAKLRRLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLLAIYLHAGPTAHELAVAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFCEPVFVRYPNGGLVHTHCAASRHTNPSSSSPGTRT
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRLLLLLLMLLQAALAVVYNWLSLALLNTSTLPIAERGSMLIDKAHYEGLCAHLTGLNPVQQQICTSHPFSIPFVSRGLRDAIYECQQQFKMERWNCSDRYEIMKTPYGYFHDILGKTLRTTTKESSYLAAIASAGIVYAVTKGCNTGNFSDCGCDSKPALQRHLEAIELNPPSAAALTSMHPGGPVPYPPPPGMPSSAYPPMGSNGMTGNGPFSWGGCSDNVGYGVRYARKFLDEFERQEFNRTSNVQHLVAMHNHFVGREAIVQNVRKHCRCHGVSGSCEFKTCWLQMPKMKDVAELLKKRYDNFAVQVTKRAKKRLRRKERSERATPIRGNEMAFVVRSPTYCERNDTAGILGTAGRDCVHDSLNADSCDLLCCGRGDKAEHLANFLICYVNWCDLPRKKISSNFVVRLRIFASLRLRSSHNNIIYFCDTTLACLAIMSIRGYSRSSSVYHVLSKHSQWLNKIFYNTRIERQVTQCNCKFVWCCQVKCKECVDDVALHTVAFWALIKMGYQKAVLPSRCHFEGSRASGLVFFPYHGRNGWRKSPVPLVPDRTVGGVAQSTMGARNSIPRPKRDKPVSSSIKVAMRGRSGGMHDNKLPTICPRRPCYLRYLKQQRVKDYLTLESEFIRRQNAQKVVEAHRKKERQTVRNLRGSPTTLARVHELFDNESRAVVVVEGSKREWFIPILSIVDKTYIHVNSLVIVKCAGAFKNVPIAVVGVLPDEVDSSAMGHKIEKAPKESFDDIGGLESQVQEIKEAVELPLTHPEYYEDMGITAPKGVILYGEPGTGKTLLAKAVANSTSATFLRATGSDLVQKSSGEGARKVRDLFKIAKESAPCIVFIDEVDAVIMATNRIDSLDPALIRPGRIDRKIELPKPDQKTKLKIFGIHTSGMHMDKDVSFEALLAKEKEASGADIKAMCTEAGMLALRAQRKVVCMADFEKAMKTVLLKDVNNIGAAFYA
The following text describes a protein:
Function:
Activates transcription of virulence factors alpha- and beta hemolysin genes (hla and hlb). Also, activates RNAIII expression, a central regulator transcribed from the agr locus.
Subcellular Localization:
Cytoplasm.
Sequence:
MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKEYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEFNISEREASDIINNLRNFVSKNFDYSDKK
The following text describes a protein:
Function:
ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction. Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER. Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Sequence:
MAASSSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGAKQETFTFALTLVFIQCVVNAVFAKILIQFFDTARVDRTRSWLYAACSVSYLGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPMAKYLCVLLIVAGVALFMYKPKKVVGIEEHTIGYGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTLLLGAGILFTGELWEFLSFAERYPTIVYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISPMQWVGTVLVFLGLGLDAKFGKGAKKTSH
The following text describes a protein:
Function:
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Subcellular Localization:
Lysosome.
Sequence:
MKLSVTLVLFLCHNIWSYDYETKYFEVLLDHFSFTNNATFKLKYLINDTFWTNDGPIFFYTGNEGTVENFAENTGFMFDIAPSFNALVVFAEHRYYGESLPFGNDSFVSPSHIGYLTSSQALADFVDLINYLQTMSLEKVPVIAFGGSYGGMLASWLRMKYPASVVGAIAASAPIWQFETPCEDFYKVVTRVYQEAVAKDCPLLITKSWTALRNISESPEGKAWLSDAWQLCSPLETSADVETLIGWYSEILVNMAMVNYPYSTSFLAPLPPFPVKTFCSQLTQANIVDDKSLVMALGDALQIYTNFTETTTCNKINQTAEALGEEGWYFQACTEMIMPMCSIDGDMFENDPWDYGKYASQCFEKWGVNQTHPELPVLEYGGKEIKAASNIVFSNGLLDPWSSGGVLKNVSESVVSVIIPDGAHHIDLRGGNKDDPETVIEARQFHVDNIKKWIMEFYFHSGKGAFFEKIKYQHVARN
The following text describes a protein:
Function:
Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks.
Miscellaneous:
MISCELLANEOUS: Present with 3670 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVAKKRNTLRSKVSARNSQNFGPDVANNGILDESYDIESDPRAFLHQPKETKKEKLLNRQNTFLSNLKGKSTLNDGIAANFDGISKSSIRRRKRKLREELKPRMQDLLTSLEQEKDLRGIIENSSKDMNNDDDIDMDSKIRFVDTKEMNLKKIEPGSVRIKKNQPNIRNQKGAKALAANETARFNQVLTNQDFQKNPFGALREVIKLQKQ
The following text describes a protein:
Function:
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Presynapse. Postsynapse. Postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions.
Sequence:
MQPWQCLRRFALAWWERTAEGRARSPREEVGPRDPGGRGEPDPERSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPASHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTSQGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSSPQKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRLQMQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTLAQIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEGTPLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVKLRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAAQGPAGSPDKGKHGKQRTEYMRIQAQQQVRVGYQAPRPLEGCTPRLCYMPLS
The following text describes a protein:
Function:
Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
Sequence:
MKIRRKGKISEGEWVVLFDSKRRYLIQVEREKIFHFHKGYIRHNDIIGMEEGSIIRSSQGANLLVLRPTYSDFILEMPRGAQIIYPKDIATILVWADIYPGARVLEAGIGSGALTIALLQAVGETGTVISYEIREDFAKRALSNIENFLGKKDNHILRLKDIYEEIIDENIDRIILDLPEPWRAIDNILKALRPGGIFLAYTPTIIQAQKTVEALKGTKSFTLIETIETLLRPWQIEGLSVRPFHRMVAHTAFLTVARRIVTQEENISPMVVPSEERGENYEIE
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPSARSSMLDRASVAETPVKSEATRRVRFRGAGFVPASSRFGGWIALALVIAIWQAAGSAGLVNPLFLPAPLAIVRAIYELAMSGALWQHLSASLLRIGVGWLLGTAAGVAVGFAIGLSRLARSVGITFISALFPIPKIALLPLLILWLGIGEEPKIATIALGVFFSTAISVYSGVDAVPRNLIRMAQSFNVPFATIVRKVIWPGALPAILAGFRITASVALLLVVSAEMIGAQYGIGAFVLQAGNLMQTDQLLAGVVILSVFGLAVGKVINLLETRLLHWR
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MARKEAVNESCLLIFMISISLLHLFTCPYTKVEESFNLQAIHDILYHRFDFEKYDHHEFPGVVPRTFLGPLVISALSAPMTCVLVLFQAPKFYTQILVRGVLGLCVILSLWLMQKEVRRQFGSLVASLFCFICTTQFHLMFYITRTLPNVFALPLVLLAFTSWVAQRHGAFIWLSALAAIVFRSELCLFFGLMLLMSLLNRKLNFGQLLYHAIPAGFVSLGLTIMFDSLFWNKLLWPEGQVLWYNTVLNKSSNWGTSPFLWYFYSALPRALASTILFIPLGLLDRRTRKLLVVSIGFILLYSLLPHKELRFIIYTLPVFNVIGACGCSFILKNYQKSRIYKIGSIVVVGHLMLNATYTSISLYVSHHNYPGGKAMQELHRLMPTTADVSLHIDVLAAQTGVSRFLELNSNWRYDKKEDLTVEDPVMKTYSHLLMEVNATKILLLKDSHKPLVFITGYQSLTFEMFHFPPLKIQLNKKLVLLERQSNKVNGGLN
The following text describes a protein:
Function:
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Sequence:
VHRWVPPSSVRRDAPLSPADKNDAIFRKVRAILNKLTPEKFHKLRKELLVVGLDSTQILKGVILLIFDKALDEPKYSCMYASLCRELCEESPNFEPPPSSSSGTNGGAPQTTFRRLLLTKCQDEFENRRRASEAYEKRQGRLSPEEQEQRLVAKHKMLGNIKFIGELGKQGLLQESILHQCVQQLLLGSGRWQQQDLECLCQILVTVGRRLDTARARPLMDQYFERMRTLSQAPELPSRIRFLLRDILELRANRWVPRRGNGEHGPRTLQQIREEASRDLGMYVSSRVTAHKGSMGGMDDVFAPLPLASLGTGPGVIPSGGDRFFPYSGRGGNSRAPLNSSGECYDPSWTCCPRGGEHLPPRFLKKQTSGSADEISLRPAQNSMVLKPKTPLSFSKGAPTSGVGNVGGPALGPHPLAKQALKEPRKREKGGDPRGGALPRVDELLNTLRAGGGRPAARPPRPTTPEEAGKAFEALKIPRKFLADALAHVMLATLDKAGGRAAAAAGPGLQEGRGPRLPGGAPGKWLPTAGLSWVFGRMAALEVEMPLVKSMVAGHVARGVARGLVSLSELAGALPNGQHYPLFLLVLQQLSRTQGRVWLTQGLAAAKVDLESVLPEGNRGPERLAEVLEDRGLGFLLPRLQGDMWRQLKADPSPNALYRWLRESLEPQQQAQPSFVHALVTCLLRHITGETTLPGLLSAANQVPERAQLDKERELAGRFQPLLRAFLGERPSLQLAALYALQTFCHSLGFPKGMLLRWFVLLYDLEVVEEEAFLKWKEDVNDDYPAKGKALFQVNQWLTWLEEAEEEEEEEEDCSDEGDN
The following text describes a protein:
Function:
Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion).
Subcellular Localization:
Cytoplasm, cytoskeleton, phragmoplast.
Sequence:
MSNRACNCLVVDEAVNDDNSVVSLHPETMKKLQLFRGDTILVKGKIRKDTVCVALADETCEEPKIRMNKVVRSNLRVRLGDVVSVHQCPDVKDGKRVHILPVDDTIEGITGNLFDAFLKPYFLEAYRPVRKGDLFLVRGGMRSVEFKVIETDPGEYCVVAPYTEIFCGGEPVRREDENRLDEVGYDDVGGVRKQMAQIRELVELPLRHPQLFKSIGVKPPKGILLYGPPGSGKTLIARAVANETGAFFFCINGPEIMSKLAGESESNLRKAFEEAEKNAPSIIFIDEIDSIAPKREKTHGEVERRIVSQLLTLMDGLKSRAHVIVIGATNRPNSIDPALRRFGRFDREIDLGVPDEVGRLEVLRIHTKNMKLAEDVDLERIAKNTHGYVGADLAALCTEAALQCIREKTMHAIDLKDESIDAEILNSMAVTNEHFQTALGASKPSALQETVAIVPEESREVTEALESVKRELQKLRLFVFFCFLCILLSFVRS
The following text describes a protein:
Function:
Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRTLTESRRRQSGSSGCKKDSESDDDENTICSRAAIKRSVVYYLKNSTLHGLKYIAEESITIPERIFFGLAFVLVVILSVFFISNVYVKWSASPIIISTSAKQKLTSNMPFPAITICNLNQALLSKVDRIGRTSTNFSLLMGLCDQGGDTTISYIGTWKYFKAILVDVAQPCEKMLLYCSFGSREEDCSWLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGGTGIRMGLTVVLNASIAEYYCTKSMSVGFKVLVHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALPTIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSCVLYYLPRIDPLARVCGPNDNQCTDRVQTEIESSLTNLSCENCWPGCFELTYRATLSTASIVSDPRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYITVRPYCASRTLRQRHKRRLEQLSWLTPIRMPVRRALRRNRGGLLRNPPPPAYSDLQKFRGKLDKPETCKRKLWRTLQVRPVVDRADEELPTYPYLD
The following text describes a protein:
Function:
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAGLRKRGRSGSAAQAAGLCKQWLQRAWQERRLLLREPRYTLLVAACLCLAEVGITFWVIHRVAYTEIDWKAYMAEVEGVINGTYDYTQLRGDTGPLVYPAGFVYIFMGLYYATSRGTDIRMAQNIFAVLYLATLLLVFLIYHQTCKVPPFVFFFMCCASYRVHSIFVLRLFNDPVAMVLLFLSINLLLAQRWGWGCCFFSLAVSVKMNVLLFAPGLLFLLLTQFGFRGSLPKLGICAGLQVVLGLPFLLENPSGYLSRSFDLGRQFLFRWTVNWRFLPEALFLHRAFHLALLTAHLTLLLLFALCRWHRTGESILSLLRDPSKRKVPPQPLTPNQIVSTLFTSNFIGICFSRSLHYQFYVWYFHTLPYLLWAMPARWLTHLLRLLVLGLIELSWNTYPSTSCSSAALHICHAVILLQLWLGPQPFPKSTQHSKKAH
The following text describes a protein:
Function:
Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane.
Miscellaneous:
MISCELLANEOUS: StnB, which is involved in the same pathway, is derived from the same bicistronic transcript that encodes these two different proteins.
Subcellular Localization:
Cytoplasm. Synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Colocalizes with synaptic vesicle pools. Colocalizes with the endocytic network within synaptic boutons.
Domain:
The Asp-Pro-Phe (DPF) motifs, which are found in many presynatic proteins, are thought to mediate an interaction with AP-2alpha.
Sequence:
MLKLPKGLKKKKKKSKKDQELFTEEELEQYKRDLKAKQEAAATKSDAGESDGASSDVEAHHEPVAFNSGLGSGSSSSILNAQQQLSDQNQGAAGGDEEWAKFKALTSGVDSILHKTQDELDRIKKESFYQRLPSAAEKKKQKEEEAARLEAEQQEREKQRLGQIEAQRDKLAEAVVQLSESEEEAGDYEADDIFATDYIEAITSGELQLAVVPDSPVLAEDGPDPFDTAYAEKVIVGADRAKGNKKLVSLGAAVEVLSGRVDREHAVALANPKRKLRKGIQNLLLSESIELADSEAELLAATSNAEPQHNLLDDLDEELSESSVPIDLSVSLHLHLIKHKQPVEEEEELEQKGRENQLLNPDLSEFDSLKDEEDDEFAELAAESLTKKEEVTVVSQVVLPVAQLPTEAFEAGSWAEFEEQSGQEPGKPKRPPPPVRPPTGPHIVPGAIYVSEDEEENPEDDPFNTNYAEQVIKKTTVLEEDDDFDPRAEEHATEPPFLAAPQRDLLAGSATDLSQVVPAPLAPTLSVDQEAEDFDPFDTSAVSALVQPKSTELRFLERELLNYSGLDGVTLKHSLSDQDFDPRADQKEPAAPQVKLEQKETDFDTAQRKSSLSLNIQAKSVGFLVPASDLLGAGNELGASKKPLTPYYAPSDNRLQEREREAEDVDPFDTSHVPEAKLSDIELKHIEKDLISVPANLRHSLSDPDFDPRAPPTPVPAEVLLAVEENINIKVLTPAQDRKKLTNSGGSGKSEEDIDPFDTSIAANLQPGQTELKLLENELLPETKTLVTDVLDVQSDAQELGLGDKVLTPSTHSRPSLPAQDIDPFDTSIAENLAPGEAEIKLLESELIER
The following text describes a protein:
Function:
May play a role in cell adhesion.
Subcellular Localization:
Secreted, cell wall. Note=May be GPI-anchored.
Sequence:
MISFVTLLAILGLLSISWADQTVRSVAGDQRVTDPVIVGDNSILDYYGGSNYDFSNNFEIGRGTLYIGKESYFSSFQSAPTDVPNSFHLLIKNTNNLQNNGQFIIENIKRHANQCSNSSIQVFPINFQNDGEFEIISGGVEGRCCLPTSVIAPQNFLNNGKFYYKVLTDTGSIYSGSCMQNVDIGASTTTTVNNNLWEFTGSINAQINGAVSGAAQINLDGSNMFVNANTFSGQVVNLINGGSFLQTSDPLSNIVVINGLGTSDTGVTSIAVKGKGKSFTYNPSSGIVKLTTVEGKTYAYQIGCGYNTKKFITNNDSGASYESADNFFVLTYSEPYSPQTCQLENSSIFSSNFISTSTSSSSSSSSASSLPSSMSSSLPSSLSSSLSSSLSSSMSSSMSSLFIIPPPYTTTRSSGSSIIDTEIVSFYSTTDSPGHTITGTTTTTLYGPHTHSSVSTPSSSSESSTTSNSSIESSSLPHTSVSSTPESSITPSSNTISSSPTSDFSSVQSSSIMESSSVVASSSVINSSSIVDSSSSSASSLPSSMSSSLSSSMSSSLPSSMSSSLSSSLSSSLSSSMSSSMSSLFIIPPPYTTTRSSGSSIIDTEIVSFYSTTDSPGHTITGTTTTTLYGPHTHSSVSTPSSSSESSTTSNSSIESSSLPHTSVSSTPESSITPSSNTISSSPTSDFSSVQSSSIMESSSVVASSSVINSSSIVDSSSSSASSLPSSMPSSLPSSMSSSLSSSMSSSLSSSLSSSLSSSMSSSMSSLFIIPPPYTTTRSSGSSIIDTEIVSFYSTTDSPGHTITGTTTTTLYGPHTHSSVSTPSSSSESSTTSNSSIESSSLPHTSVSSTPESSITPSSNTISSSPTSDFSSVQSSSIMESSSVVASSSATQSSSVINSSSIVDSSSSSASSLPSSMPSSLPSSLSSSLSSSLSSSMSSSMSSLFIIPPPYTTTRSSGSSIIDTEIVSFYSTTDSPGHTITGTTTTTLYESSIYSSSSSTIQESELSNTSRTTMTSNSSVSISSTSSRSSFSNTKSSTIVISQSASLPDSKTDIILSTSSNIGYSSRSLLSDLGTSISDSDIHHSVLHSTESYSSNESGTNPFTSIASLSNFIPESSSHTSTALGSENSVISSDILTTMSHPVATNSGDKPTTPKRSEQVSTTMTSSGPTPDTSSFDTDGMSAYSRPEFTTNSLEVNKSSTSQLGNNKQTFSNLQLESTRPHSENEVDNNTRLLQSIQQSSTYGTNNVNPLSPTGSISIPLTEDGQGDNNNWNSPATNDLCTQISFNLTATTITVTDRITITDSIHDISSEVITSYIYQTIVDQKTVTQTVDGKSLANKMSSIPKPSSRSLIQPQPPVAIELQEGAASTSRVSLVSLFISIILVLL
The following text describes a protein:
Function:
Functions in cell cycle regulation. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes.
Subcellular Localization:
Nucleus.
Sequence:
MSEPDPQELGAEVVSGLVATSDDRLEMINAEYTNLCRDLNMDRQTELQGYETYLEVSQRCSMEGTASHWMCCAIYTACRRTSTPTVTGQNAVVKGNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLPQEFVNEIEDLDRKFSITFMLHKRFRIIMDMIFSCPPNEKKHSKYISLHGNHAHGKCSYIKLDDICWRLFLCAKNQKPSNTVDLVTSYNLMICCIDLIYNNVLAEKRTDLINPKFEGLPSNWTELDFRHNPHCILSNFCDMTEEAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFERNLKSLNISYEQYVLSVGEFDERILSAYDAGEHTALNDQSLRPPVTPLTRKQDLPAQPAMAGDKFEPVRNATNNVKQLSAFGRITEPTDFVKQAGEEVIAKLLSIIEEIEQKFLAKYPSTEAKSRFQLAKSFFFYLLDQILQAEIRNKPDIDLKRLLVQKVSLVIFNITLMACCVELVLEAYKTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGCLNRSLIKHLNSIEETCLERLAWARNSTVWEMIASAQLPLPTWLMVNLDRAAGPLQIFLRKVYLLGWLRIQKLCSELSLCEKTPESIWHIFEHSITHETELMKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFIDINEDGEPKVKDIIHFYNHTYVPLMRQFVIDYLNVTPDVSGRASDLQLSPHPKERAAQPKKVTQSHSLFVSQMSKNEIQQSPNQMVYSFCRSPAKDLQAMNEKVRGGKRMLSFGDEPGLGTMAETKRSKISQVKAVMDDPELQSAEQQTAVTTEGCVGGEGGEHET
The following text describes a protein:
Function:
Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MDAFTGSGLKRKFDDVDVGSSVSNSDDEISSSDSADSCDSLNPPTTASFTPTSILKRQKQLRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHREILREHLKEEKLHAKKMKLTKNGTVESVEADGLTLDDVSDEDIDVENVEVDDYFFLQPLPTKRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCRLYCDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKLELESKRQVSRPAAPDEEPSPTASCSLTGAQGSETQDFQEFIAENETAVMHLQSAEELERLKAEEDSSGSSASLDSSIESLGVCILEEPLAVPEELCPGLTAPILIQAQLPPGSSVLCFTENSDHPTASTVNSPSYLNSGPLVYYQVEQRPVLGVKGEPGTEEGSASFPKEKDLNVFSLPVTSLVACSSTDPAALCKSEVGKTPTLEALLPEDCNPEEPENEDFHPSWSPSSLPFRTDNEEGCGMVKTSQQNEDRPPEDSSLELPLAV