lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Bifunctional enzyme involved in flavonoid metabolism.
Sequence:
MSKQGEGKKVCVTGASGFIASWLVKLLLDRGYTVKASVRDLGQSHSLSGYLYIYHIIFQLYPISYILWATMKHTVSDVLIHLYFLMSASSDDKKKTEHLLALDGAKERLHLFQADLMKPGSFDAVVEGCDGVFHTASPFFIHTANPQVELIDPAVKGTLNVLSSCSKVPLIRRVVLTSSVVALMYSGSPLTPEVVVDENWFSDEGFCKETKLWYPLSKTLAEEAAWKYVKENGMDMVTINPAMVVGSLLQPTLNTSVAVIFRLINAPTYPNITLGCVHVKDVAIAHILAFETPSASGRYCMAESVVHISELVQMLRKLYPSFKLPDKCADDTPFVKYQFSREKARSLGINYTPLEEGIKETIESLKEKKFL
The following text describes a protein:
Function:
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFNRPPNGVYYIRSAVELRAFVNLLKKFKGYATTLITLYINAERPIPDVVNLLRSEWSTAANIKDKTTRTHVQDTLERIINNLKGEAKAPENGMAVFAGFHMINQGNYEWVYYVVIPPQPINTFKYICDTAFHTELLEDQLHAGVVYGIVVIERGEAVIALLKGGQWEVVKSVEFFVPGKHHAGGQSANRFKRQTEHLAEAFYKMVAEEANKIFLQIPTLKGIIVAGPGPTKEDFLEEGGLDYRLKDKILAIVPACCANEYGVMEAIRNAQEQLKESEYVKAKEVMDKVMYYAVKKSEYLVYGRERALKALEMGIADIIVIAEELGEDAVLEVIMKAEEKGIKVEVVPRGVEESKTLMQAFGGYVALLSTPVWVLEQQLSIAEAAQR
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGYQAYQPPIDTKHYSNLAIVLTFIGFCFLSYFVIYQVTQNKQQRSLAKELSVGLFASLFLSSGTLFSFLALGLFF
The following text describes a protein:
Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Subcellular Localization:
Cell membrane. Late endosome.
Sequence:
MTMARASLAHGPLSPLVVSQLDINAVDPQGRTPLRLAIVLGHEACVQALLDCGAEIGDVDAEGWSAVHDATCRGNAGLLEQVLNSRNFRLQQDTEDQVSDLLALLRDTPDFEVCPTSPCVLGDTCHLWKIGSNLRFDMTLLGFENMKWVRGQRSVCFSLPQSTDQSSDNEAGANIEVRYIDHDTQSAYIETMEARPPNRQADSKEIRARLNAPVTTTKMSEDVSFQRLKSGIWGFQRNRTESVGPYECSVYGTNHLTLETLTRLEHLPKNHPARQRSSNPISSMMRAAGGQDNSDAEAQEVGCFDALTASQGGGTEAEQVEALETEHAGDHGLSFEEYIATPAARKRLVVGRPREVKRKKQTLNLNMWMSPDFPLSFRNQLLPILDLLAPTNRHVAKLRDFVHLNLPAGFPVKLEVPLYGVLTARTTFENYRALDADVLAGVSTDDLFGVPTGYRQLLAGQAEFGSEDERMLAMALQASMHQGYGADEFEGYFEVNGSLGDEAALQEAILASMGRSSETIQGQPMQPVTEEELIAQAIALSLQESGSNSNSAPPSNPGPAQPADLSSLSEEEQIRLAIERSLNT
The following text describes a protein:
Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex. Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
Sequence:
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
The following text describes a protein:
Function:
Phosphoglycerate mutase-like protein lacking PGM activity. May play a role in carbohydrates metabolism.
Sequence:
MSPDNKLLPKRIILVRHGESEGNLDTAAYTTTPDHKIQLTDSGLLQAQEAGARLHALISSNPSSPEWRVYFYVSPYDRTRSTLREIGRSFSRRRVIGVREECRIREQDFGNFQVKERMRATKKVRERFGRFFYRFPEGESAADVFDRVSSFLESLWRDIDMNRLHINPSHELNFVIVSHGLTSRVFLMKWFKWSVEQFEGLNNPGNSEIRVMELGQGGDYSLAIHHTEEELATWGLSPEMIADQKWRANAHKGEWKEDCKWYFGDFFDHMADSDKECETEATEDREEEEEEEGKRVNLLTSSEYSNEPELYNGQCC
The following text describes a protein:
Function:
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MASLSTITQPSLVHIPGESVLHHVPSTCSFPWKPTINTKRIICSPARNSSEVSAEAETEGGSSTAVDEAPKESPSLISALNVERALRGLPITDVDHYGRLGIFRNCSYDQVTIGYKERVKELKEQGLDEEQLKTKMDLIKESYTILSTVEERRMYDWSLARSEKAERYVWPFEVDIMEPSREEPPPQEPEDVGPTRILGYFIGAWLVLGVALSVAFNR
The following text describes a protein:
Function:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MQSSMWSFLQKKEGGEIEDIEKKISNAQELNKLKTSPKKKREAVVKEKVEKKEKKETKPKRKSSKKNKEEEEEEEQEEQDGEEEQEEEEEYQQQDEEIEEDINGEEEMELDENEKEKNKKKKQSLKTKENKESKSSSSSKKTIENKETKKPEKQSSKQSNNLKRLKRKKMDDDEEDEEDENKTDDNDLDDMLDDDSDNEKDSISSKDKEYKEKVLKDKEKKEKEKKEKELKEKESKEKEKKEKEKKEKEEKDKKEKELKEKELKEKELKDKKEKELKEKEKELKDKEKKEKELKEKEKKEKEEKEKEKKEKKEKELKEKEEKEKKEKELKEKELKEKELKEKELKEKELTSPKKETIDISDLFKRANAEAKSSVPTSTSKNSKTNKKQKVDHKPTATTKKPSPVLEAKQSTTTTTTTTTTSTATTISSKSISSPSKKEEKEVITSKKQVEATKVEVKKEKEKEKEKEKEDDEEEEEEEEDDDEKLEDIDEEEYEEEEEEDEEGISENEEEEEKKSTQIKSKFIKKVPISKKKGNAKTIQADLKVIGKYRPIEDAQWKKGEAVPYMVLAKTFEMMESTSSRLIIIEHLANLFRSIMLLSPKDLVMTIYLSINKIGPSYQSKELGIGEHVLIKSLAESTGRSVDVIKQELTEVGDLGIIAQNSRSTQTLMGKPTPLTIQSVFKTFQQIADLSGTGGQQKKKDLIKKLLVSCKDCETLYIIRSLQGKLRIGLAERSVLMALAKSVLVTPPIDGSGQQIFDIRKQMKQEEFEERYQNVVSKVTRAYSQLPNYDLFVPHLIAVNGIDNILSTCSLKVGIPVKPMLAQPTTGISQMLDRFSDMEFTCEFKYDGERAQIHRLPDGTTHIYTRNLEDYTQKYPDIVANVTKFVGPNVKSFILDCEAVAFDAATKKILSFQVLSTRARKSVQLSQIKVPVCVFAFDLLYLNGQSLIDEPLIKRREHLVENFIASDGVFAFAKYSNISDVNDIQSYLEEAVEGNCEGLMVKTLKEKSIYEPSRRSYNWLKIKKDYMQGMTDSLDLVPIGAWYGKGKRTGTYGAYLLACYDENNEEFQTLCKIGTGFSDEQLTTFTSQLKPHLINQPRNQFRFSDSIKPDVWFSPSCVWEVLAADLSISPVHTAASGILDPNKGIALRFPRFIRIRPDKSPEDATSSDQVVDMYQNQKINSQSSKINEKDEDY
The following text describes a protein:
Function:
Involved in storage lipid mobilization during the growth of higher plant seedling.
Subcellular Localization:
Glyoxysome.
Sequence:
MGAIAPLQKMGVAVNYEVKHRDQPGVIGGDSGIIRIRNGSTVMQPTFGNLESQRIYQDWRDNPRWHRVTRPYRAEDVIRLRSSRSPVQGEKAVAQGLWSTLTNGASTDSVRQLYMEEALIPAHSDDLAKTFANAQRLIAAGHAAAVVDADAVAAQPVPHLVAARLATDVHDTPLVLMARIKAASGDAALAYACAPYADVIWYEASSFDPAAAKRFIDTVRRLYPRQLVAYSCPASAVPDNSDWQDELREHGFCDVIASQPRQRLADAATAARLHRDFGSEIDQLIAHSLERGASRDFSGETFCEETAEKDLV
The following text describes a protein:
Function:
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).
Sequence:
MEGRHKEYRIRFSPGWVEVVQDDVTIPGRRALITGATGLLGRAVYKEFKENSWHVLGCGYSRARPRFEYLNLLDAAAVKALIQDFKPHVIIHCAAERRPDIVESQPEFASLLNVVASENLAKEAAGVGAFLIYVSSDYVFDGTSPPYREDSVPNPLNLYGKTKLEGERAVLHNNEGAAVLRVPVLYGDVEKLSESAVTILFDKVQFSNKSANMDHWQQRFPTYVKDVASVCLQLTERRLQDPSIKGIYHWSGNEQMTKYEMTCAMADAFNLPSSHLRPITDEPVGATPRPWNPQLDCSKLEKIGIGQRTPFRVGIRESLWPFLVDKRWRQTVFH
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MPLTISTPLLHPTSFRNINLLFRTAPRYIQNQFRCQSTTSTSNSSVNPDEVSHFNALASTWWDPHGSSRLLHLMNPLRHDFIRTCHASQPVAPATSGLRYLDVGCGGGIFAESAARLRSSGSVTAIDPSPVVLSVAKAHARKDPALAGKLTYLNTSIEGLSIPKTKEEQYDVLSLFEVIEHITYPSSFLDKCMPFVKPGGWIIMSTMARTWTSWLTTKVVAEDVMGIVPRGTHDWYQYINEEELRGHFLRERGWNSPIVRGVVYVPGLGWKVVPGSEKVGNYFFGIRRDEVRRV
The following text describes a protein:
Function:
Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
Subcellular Localization:
Cytoplasm. Nucleus. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation.
Domain:
The nucleotide binding domain binds ATP with low affinity.
Sequence:
MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
The following text describes a protein:
Function:
May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.
Subcellular Localization:
Nucleus.
Sequence:
MLAGQLEARDPKEGTHPEDPCPGAGAVMEKTAVAAEVLTEDCNTGEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNMELREKLRALQLQRWKARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKNQSATLLGQRSSSNNSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTPCAERRGGV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPTYVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQFVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYVVAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIALEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQYSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPSTVSVPYPVCVKFLHQV
The following text describes a protein:
Function:
Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase gpi14 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MDLQRTNQDTGTTTLFKVVISNTVNYLPKGVWILRNNTIDSLSIAKQFREIKNNINISHLSRENYWVETPFGKVFHSEVVSEEFMQIFIDKGNKALNNEEMIFACMSEKGWNVSLETVPNLDIPVGSYETQLGLPVGLHPKLHVHLKNLHKPEDECSLQGFMYIPPTLFIDRYELSNIAEMHADNLGHVLGIWGETDLEAPSYKLNGTGSFFWFDIYTDDGLLQKDYIDTIIPLHTRYQSPLKGQTYLKTSLTNPKFFWNCDTEDKVNDFRFLFSSKNKYTLQNDPTTLSISIPIADLSYKHVVEWVTNGVAIFSFFYLLLYLWKRFRYAKD
The following text describes a protein:
Function:
May function as a coactivator for aryl hydrocarbon and nuclear receptors.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm.
Sequence:
MEKTWRVEFRNVGSCYFPQSRVDCHYTINPQHTWASNDWIGLFKVGWSSVKEYHTFVWAVAPSSYKEGTSVNCCVNFQASYLPGPSAQQYQFVYVDGKGEICSCSAAFTFSAPKPLEELVTLEEEGQGEEVGEDMLLVIPRAQLLQSRLQECLKERAELLQALEAADQNVEREKGRRERDRGSWEHTRKELERKIDDLKEEVREYREKVEDMKKKQKEVEDLGEALTEEKRALLAQKEANEQRIRELEEDIKILTQRGLERETDLERMRERAKKSAAQKREDEDEHKNLKLKMEQTEKELHSLSAEFQSLRSSLAQRDTHALQLRDTITTLTHKLNSAHRKEAANELALNELRSVQERLNVSEHCVETLRGELRDMVAQRDSAHAELHQARLQAAQLTLQLADASLALREGRANWAQERETLQQNAEIDKVRLERQNDEIQQKEEMLQKARMEREKAVVELGREKDCNRELKASLRVAQKEKEQLQTEIQEVMEYSRQLERRLEVLSDCKWSETALLQSSRAESPLLSDSEDENPEALQDTHSSGPLNHYSLCEQPQSDLLLPATPPPSPRHPSTVVISQPAPLSSPHQPSARSHTHSSESEEEYEAALSGGHSSGEETALLLPDNRDTTLGELAESPLW
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MVDWSTLPKDLLDLISKSLESSFDLIQFRSVCSSWRSAAEPKSPLPTHHLPILPDNGGSLFPDSAVGFRLSQRSILLIKPHEPCIESDSFGWLIKVEEDLNVPRKVTLLDPLCDTRNSIPENFPRVLDMSKFKVRELGREFKLHYFNTVGDIVESLYLEKAVVKYLDCDGDYKFVLLTIHVSGKLAVFRSWDRAWTVINDMPSPYDDVMLFDGRFFAVDNNGRTVVVDYSSLKLTLVASPVFGGDKKFLIESCGEMLLVDMYLSLEAVEGDPGFVEEIFEHPAFYMNERTVKFKVYRFVEREESWVDVYDLEDKMLFLGDDSTFSASASDILPLCDGSSVFFNGNVFNGEDLGAMQDRDLGVFDFRSGKIELVQKLPEYAKLFWPPPPWITSHARAEDHIGETSSQS
The following text describes a protein:
Function:
A cysteine protease that proteolytically removes the C-terminus of pmt3.
Sequence:
MIGKRNASKRTRQDDCITYEEYQRKRKKTFLNTFVNICSRTVTYAKLFLTKTPISELDRIAGEAIPSNSNSTNSKLEPSTKAPESRFSHINSKTERGYVTVESDMSSHNTLDRNSKPTVSHSYTNSSKDEKFLDPIALQNLFSPASDTHSQNIHDEALSPSSFRVSRSRYFPRPHRSSKNLSVSNRLQLAVFKETTSSTLSHGNSVEADEINSFNPTPFSSSPLHFTNSSPNPNSDIVTPDKQLDVVSEHARYKHLPFTATLRKKSPHDSTSRKASFRFVQSDQQPARNIVTSDIQNEKSLLLLIRDLKEKQTESFQDWNEVDFLQLKGLEISPPPTRPKFIPELEFPDNARKRALKYLNQSNSVSSSEPIITKFNIPITLKDLHTLRNRQWLNDEVINFYMNLISERSKIDSSLPRVHGFNTFFYTSLQRRGYAGVRRWAKKARVNIADMDAVFIPVHLDVHWCMAVINKSKKRFEYWDSLAGSPGKVFDLLRDYYIAETKGAVDVSDWENFMDDNSPRQRNGHDCGVFACKTAECVSRNVPVQFSQNDMPELRIKMAASIIDAQIY
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Sequence:
MDGRRRRPMPLPQAGEVRKTTGATTMNIQTPVKVDKAERMRRARGEAYATPLAQFHPGAPRLFQDDTLWPWFERLRKEEPVHYCTNAPIEPYWSVVKYNDIMHVDTNHGIFSSDSTLGGISIRDVPEGYDYPSFIAMDQPRHSAQRKTVSPMFTPTHLDELAKLIRQRSQTVLDNLPRNETFNFVERVSIELTTQMLATLFDFPWEERRKLTRWSDVSTALPKSGIVASAEERRREMDECYAYMSKLWNERVNSAPRNDLLSLMAHNDATRFMDPDNLMGNIILLIVGGNDTTRNTMTGSVLALNENPEQYDKLRANPALIDSMVPEVIRWQTPLAHMRRTALQDTEIGGKQIKKGDRVVMWYVSGNRDEEAIDRPNEFIIDRPRPRTHLSFGFGIHRCVGMRLAELQLKIVWEEMLKRFDRIEVVGEPKRIYSSFIKGYESLPVRIPG
The following text describes a protein:
Function:
May bind GTP and have GTPase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MWRRQHALLRRISLPKPPAATGIGCYYATEPEGRKPKTAPLQSRGMVDRFRLRAKGGDGGNGCISLRRSRSDRQGKPDGGNGGRGGDVILECSRSVWDFSGLQHHMKASRGANGVSKNQIGTRGSDKIAQVPVGTVIHLVEGEQPSLSVNKPTRALDPWDIPDAVEHSPFSSSRIGSKMMKGLDSSRSSQHISSKKNTAENDCERGNRNHRGKEPYYMTEFVRTEDYDGTSYPHQVGVDENDQFDDEDDEFWEDDEEELDMEEVTEEKEEEEDVRYSVAEMTKPGQRLIIARGGEGGLGNACILKEMWLSKAHKEEEMASLSTGHPGTETYLILELKSIADVGLVGMPNAGKSTLLSALSRARPEIADYAFTTLRPNIGSLTYEDYFSVKVADIPGLIKGAHENRGLGHAFLRHIERTKVLAYVLDLAATLNGRKGVPPWEQLRDLVVELEHYQEGLTKRPSLIVANKIDEEGADEMYEELKKRVQGVPMFPICAILQEGVPDLRVGLRDLMDASDPQGIELSKIVVD
The following text describes a protein:
Function:
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sequence:
MSNSGRWRRRTRSVAPSPATSSPSSPGLREAQPFRLPQWKFSQVLGELPPAAEARRDGAPRPQDDDDADEISAIEFDGRGEYLAGGDNAGRVILFRRTDGDGDDARPRAELERTDRAGAPPPRYSYATEFQSHEREFDVLDSLDISERIKKVRWCARPNSSLLMLAANDRTVKLWKVSEHKAEAPKKGNGRPSWGTAALSAATKLPRGCSSAEPDERPEKAAGDVGDGYSAKCRRVFGRAHEFNIHSVSTNCDGETLVSADDVRINLWHAEVTRQCFNIVDMKPADMEDLVEVITTAEFHPSSCSMLAYGSSSGLVRLVDLRRSALCDHSVRMFQDRENRPQPSTFFSEIISCITDLKFTGDGEHLLTRDYMNLKLWDLRVETSPVATYKVHEFLRPKLSELYTDDYIFDRFGCCASNDGAYFATGSYSKTFRVFSRAAAQTCGATLEASTNPYRIQLHAPTKIPALLSNFSLGVHRKGQDGHPRSDGKEQVSCNMASKSANHRTAFVAN
The following text describes a protein:
Function:
Its role in unclear. In contrast to NINJ1 paralog, does not mediate plasma membrane rupture (cytolysis) downstream of necroptotic and pyroptotic programmed cell death. While it is able to oligomerize and form filaments, filaments are curved toward the intracellular space, preventing circularization to mediate plasma membrane rupture. May act as a homophilic transmembrane adhesion molecule involved in nerve regeneration. Promotes axonal growth.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Composed of 4 alpha helices: 2 hydrophobic transmembrane regions (alpha3 and alpha4) and 2 alpha helices (alpha1 and alpha2). Alpha1 and alpha2 feature one hydrophobic side and a hydrophilic side. In contrast to NINJ1, does not disrupt membrane integrity. NINJ2 filaments are curved toward the intracellular space due to cholesterol-binding, preventing circularization and ability to mediate plasma membrane rupture.
Sequence:
MESDRETIHLQHRHSMRGGNQRIDLNFYATKKSVAESMLDVALFMSNAMRLKSVLQQGPFAEYYTTLVTLIIVSLLLQVVISLLLVFIAILNLNEVENQRHLNKLNNAATILVFITVVINIFITAFGAHHAASMAARTSSNPI
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
Miscellaneous:
MISCELLANEOUS: The Rieske protein is a high potential 2Fe-2S protein.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSNAPLNQGRRRFLTATTAVVGGLGAVAVAVPFIKSWNPSAKAKAAGAPVEVEISKLEEGQMVRVEWRGKPVWVVRRSQAVVEGLKSHENQLRDPNSDELQQPNYAQNPYRSIKPEYFIAVGICTHLGCSPTYLPDSFSEQVQGVKSGFFCPCHGSKFDMAGRVFQAVPAPLNLVIPPHMYLSDTRIVIGLDETGEA
The following text describes a protein:
Function:
Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.
Subcellular Localization:
Nucleus.
Sequence:
MATENNPQSNLTAVRQNDRLAPARGSRTMVIDQDSSSHQGEDSQANNSSSAATLILRAGPLQDSQPRQPRVQWQENVIDNEGLGRKKSKVCCIYNKPKAFDESSDESDHSDSDCCPTRSSGARPCPSTTSTTQARLGSTSQPTPSHSLPTPPRSPNAYEAEPSKSKGKGKA
The following text describes a protein:
Function:
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPRKKSAAKKAREALVQKKVINSNVPTDKKSIDQLQENVTSKSHLLEESSSEDEEINSFQINEEYAKRFEHNKKREELQKLEAKYGEQMANGVDGEGSDESSSEEEEDSDGELVTPEVDAAILRMIVKIRNKDPDLYDSQQKYFDEVEKDVQGSLKSKDGFRSVTLKDYHRQKLLSGEILDAEEDEPMPNDANPTHVEEQERLRKETIAAFHDVNGNKDAVSNESDEDGDFLVKKEKTKKQLEEEEHGYERFLLESAQSKEARKVLEDLSSSYVKQRPSVLVNTEDDENGIKPSDEDFLLKYMMNRGWRTSNTKQPSYEEIIDEVDAENRFDEDAEEFENKFNFRFEEEAGSQIVSHPRNVADSLRRKDDSRKRARDRKKERLEEASQKRLEEVNRLKNLKRKELEEKLNQVIEIAGSKNIDVSKLDLDEDFDPEKWESKMSEIFNENYYEEDSAKKPEFGDDIDIDDIAQVDNGSEDLGSIENKTVEDTGNREKSKKSLRKDIREKKRKIDEYVEEKYGVPEAVIVKNSKFRYQQVAPETFGLDILDILNASDADLNNYVGLKKMTPYRTPEEIARDKKKYGKKKRLREWKKQVFGK
The following text describes a protein:
Function:
Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein.
Sequence:
MASLYPRTLGGFTLLLLALAVTITPGGGQALITPLDSPLLATKYRGFREIMFNFIGQTGNNKNKFLINLKKGKVQKQFGPEEPFFCNTTGMRSETVPTSVDRLRPGDIDIIGAIGDSLTAGNGAMATNILEVLIENKGLSWSIGGQGTWRQFLTLPNILKEYNPKLYGYPTKDGLSTRKASLFNAAEGGAMSQDIPYQARNLVKRMLSDRKVDINNHWKMITLMIGGNDFCAEICYMATPEKILQYHEKNIVSALRTFRDYLPRTFVNLAASPKVDILARFKNKPQECVSMHVIECPCLLATRFRKQRERFVKLIEDWNMLQMDIAAREEFHRKPDFAVVYQPFTMNLTFPETASGDTDFTYMSLDCFHLSQKGYALASNALWNNMLEPVGGKSMNWEREFTLFRCPSAEMPFLRTPGNS
The following text describes a protein:
Function:
Forms part of the polypeptide exit tunnel; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Sequence:
MIQVPVYNQKAEKVGEIELKEELFGVERRPDLFYTCVVMHLANGRQGTHSTKRRSEVNRSGRKVWPQKGTGHARQGDRKATHWVGGGRPFGPKPRDYSYKIPKKMRRLAIRSALSTKLKENNLIILDKIELPQPKTKELVNILNNFGLADSKVLIGVPTKDENLKKAAMNLERVKTMIASVLNVYDLLKYDYLILTVDAIPVLEEAFLK
The following text describes a protein:
Function:
Glycerol dehydrogenase involved in the assimilation of glycerol.
Subcellular Localization:
Mitochondrion.
Sequence:
MIGPRLCAATPRFPLVSLAHRNSKVFALASSNAVAQRWGKRFYAPIETETPHKVGVEFEESKDRIFTSPQKYVQGRHAFTRSYMYVKKWATKSAVVLADQNVWNICANKIVDSLSQNGMTVTKLVFGGEASLVELDKLRKQCPDDTQVIIGVGGGKTMDSAKYIAHSMNLPSIICPTTASSDAATSSLSVIYTPDGQFQKYSFYPLNPNLIFIDTDVIVRAPVRFLISGIGDALSTWVETESVIRSNSTSFAGGVASIAGRYIARACKDTLEKYALSAILSNTRGVCTEAFENVVEANTLMSGLGFENGGLAAAHAIHNGMTAIHGPVHRLMHGEKVAYGTLVQVVLEDWPLEDFNNLASFMAKCHLPITLEELGIPNVTDEELLMVGRATLRPDESIHNMSKKFNPSQIADAIKAVDSYSQKWQEQTGWTERFRLPPSRHSPHLTDIHP