lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytically impaired chitinase that binds efficiently to chitin, but not to chitosan, xylan, or cellulose. Despite the lack of chitinolytic activity, retains substrate binding specificity and acts as an effector to prevent chitin-triggered immunity by sequestering immunogenic chitin fragments. Does not function in the protection of fungal cell wall against plant hydrolytic enzymes.
Miscellaneous:
MISCELLANEOUS: In plants, chitin acts as a microbe-associated molecular pattern (MAMP) that is recognized by lysin motif (LysM)-containing plant cell surface-localized pattern recognition receptors (PRRs) that activate a plethora of downstream immune responses.
Subcellular Localization:
Secreted.
Sequence:
MFTPLSSVTALLALSSAFLGAQAGCKPKNYGPEKPHGGNGGNRGSGNGNSTSKFIAKGYYTGWNSDDFKPEQVSWSKYTQLAYAFGIPTDSANFNLSLDASNAESLDPFVTAAHEHGVQVTLSVGGWTGSLHLSYAVANAQNRTTFVKTLVDFVVKHKLDGLDVDWQSPNKLGLPCNAINANDTANLLLFLQELRKDPVGAKMILSATGNIVPWTDANGNPSADVSAFGKVLDHVTPLLYDVWGSWSDSVGPNSPLNDTCAAPDKQQGSVVSAVAKWNKAGIPLEKIVLGVGAYGHAFSVNKTKAYVNGTKELAAYPPFNKDIHPKGDKWDDPAGVDPCGVATPDGGIFTFWGLIEHGYLNEDGSPKRPYRFDNCSRTAYAYNEEEQVMVSFDDAQAFKEKGAFIKSQGLGGFSVWNAGSDHKDILLDAIRSGAGLSK
The following text describes a protein:
Function:
In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.
Subcellular Localization:
Chromosome.
Sequence:
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTKSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEEEEEEEDEEDEDEEEDDDDE
The following text describes a protein:
Function:
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
Sequence:
MFPQFASTAASLTRATSLMNRVGTDAYLYDDPEDGNIAMLLDSKFEVEKVEGMKRLIALVSQGRDVSSFFPQVVKNVATTSLEVKKLVYIYLVHYAEKRPDEALLSINSFQKDLSDLNPLVRAWSLRAMSGIRVRVVVPLVVMAVTKCTRDPSPYVRRCAAHAIPKIHAIERDLHKEALEEMVDLLLNDSSPSVIGAAASAFLIICPEKLSILGPRFRKLCEMLPDVDEWGQAVLLDILMRYAVARYGCVRGAGQNSCARNDLQHKVQKMHSTDNSDHSAEEASEVELPADIRGLLHWSTPLFRSQNSAVVMAVATLYWVFAPDTDLKKIVQPLLFLLRSSKDSHYVVLANIATFALQMPPLFASYFEEFFVRSFDTDPIRALKLDILTTIATEASIHTILREFQAYLRDVNRQFAANTVSAIGRCAVRLPAVRSACVDGLLMLAKGVIVGDGVSHSKDEAEQLSCQGGLKMPAKEKLSQEAGVVAQSVLALRSIVQQNPSEQEQVFARLVRLLDHMKVPEARAVVIWMVGEEGLNSELVSQMLPVVLRYLAVSFTKEADETKLQILNCAAKIVLKLEEASASILKETATLVLEHTLNLSDLDTNNDIRDRARMLRRLVLPKSHVISQSKNREIHLDLAQQMQSLGVDNEATNVSNQEPKTVLGANGHATFQLSRADVLTKLAKQLLLVPKAPPVLPALAPDRSSFLPGTMSHIVNHNAPGYTSLPKPHSLDVVADGNTPGSARDSTLHKHERSLISGYTESGTEASGDSGGGDSDGYSDDSGPYDSGSEDSRNEESSSSQNILGKGTQIQGQGGTDLAPLISMDDESAGGELTKGNGSLYYGLPVKSDRDLDSWLDSQDVEAKGYSQTADPSSLLGYASISLGPLNPVLSKITLLDYTNGDGLDVKYTYVREPAICSQEMVCLRLYFFNRSGDPMLKISVKGMEEPASVDNADQAGVTSEGRKVISFEEIAELAPGDTIERDLQVEFKHQLTPIKLFVVLNGKTYPAKIAPEVGALVCPLQLTRNQFITAQSRISGMLESSRRCLLGSSYSQTSNTGDDKILFISRAIASSVLRVAHVAVVSATLPISDAIGFSGLQLCFAGETLTERLKCLISVTFDTENAVLIKVNCEDTVFGLNLLKQLETILSS
The following text describes a protein:
Function:
Required during female meiosis for bipolar spindle formation in the absence of the centrosomes and chromosome homolog segregation. Also has roles in male meiosis and mitotic divisions of the early embryo.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Sequence:
MDSKEVSEVPRREVRSFLMARDPSIDRRFRPRPNKKMRLFDNIQESEEESFSEYSDTESEYKYQSSEATEGASCATSAADSSNVETGPQVFLRLRPVKDASKAYIVSEEANVLITSCKVDSTSNNVNRMEKHFGFTSIFDSTVGQRDIYDTCVGPKIMEEECVTIMTYGTSGSGKTYTLLGDDVRAGIIPRALENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYNRSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPVIKQHRVSYCGFMEFSKMSTCEGGDYTKELEDENVRLQLEIEQLKYDHVLQMQLLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIEDLKDEIEELKNPASDTDISDDPNESKSPIEILDDD
The following text describes a protein:
Function:
Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.
Miscellaneous:
MISCELLANEOUS: Present with 3620 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
Contains X-F-X-F-G repeats.
Sequence:
MSETNGGNAARENSEVKQTAVENPIDKLDGTPKRPREKDQDEQAEETSDKSEAPNKNDEEKKEEGKKDQEPSHKKIKVDDGKTVESGIVEDDKKEDKFVFGAASKFGTGFGVAKKDTKDGDATTSTESLPASDSKTKKPFAFGSGLSFGSGFNILKNKTENNSESEKKATDVDKDKVHSGSEQLANASEDTKDKPKPLKLQKQEVKSGEESEECIYQVNAKLYQLSNIKEGWKERGVGIIKINKSKDDVEKTRIVMRSRGILKVILNIQLVKGFTVQKGFTGSLQSEKFIRLLAVDDNGDPAQYAIKTGKKETTDELYNIIVKSVPK
The following text describes a protein:
Function:
Involved in the biosynthesis of strigolactone natural products, bioactive compounds promoting plant fitness and soil microbe interactions, but preventing shoot branching. Converts carlactone to carlactonoic acid by catalyzing consecutive oxidations at C-19 to convert the C-19 methyl group into carboxylic acid. Prefers 11R-carlactone to 11S-carlactone as substrate. Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.
Miscellaneous:
MISCELLANEOUS: The branching phenotypes of the max1, ccd7/max3 and ccd8/max4 mutants can be rescued by exogenous treatment with the synthetic strigolactone analogs GR24 and 4BD (Probable). However, the max1 mutant does not respond to carlactone (CL) (Probable).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MKTQHQWWEVLDPFLTQHEALIAFLTFAAVVIVIYLYRPSWSVCNVPGPTAMPLVGHLPLMAKYGPDVFSVLAKQYGPIFRFQMGRQPLIIIAEAELCREVGIKKFKDLPNRSIPSPISASPLHKKGLFFTRDKRWSKMRNTILSLYQPSHLTSLIPTMHSFITSATHNLDSKPRDIVFSNLFLKLTTDIIGQAAFGVDFGLSGKKPIKDVEVTDFINQHVYSTTQLKMDLSGSLSIILGLLIPILQEPFRQVLKRIPGTMDWRVEKTNARLSGQLNEIVSKRAKEAETDSKDFLSLILKARESDPFAKNIFTSDYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEIDGFGNRDLIPTAHDLQHKFPYLDQVIKEAMRFYMVSPLVARETAKEVEIGGYLLPKGTWVWLALGVLAKDPKNFPEPEKFKPERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLDYGIILSFKNGVKLRTIKRF
The following text describes a protein:
Function:
Required for resistance to the DNA-damaging agents methyl methanesulfonate (MMS), cisplatin and oxaliplatin, but not to mitomycin C. Plays a role in protection against mutation accumulation. May be a component of the recombination-repair pathway.
Miscellaneous:
MISCELLANEOUS: Present with 876 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MEVLKNIRIYPLSNFITSTKNYINLPNELRNLISEEQESKLGFLHIIESDFKPSVALQKLVNCTTGDEKILIIDIVSIWSQQKQRQHGAIYMNSLSCINITGLIVFLELLYDSPMDALRRCQVDNFNFQLRGIVIDNLSFLNFESDKNYDVINLSKFEKLFKILRKLREFLGCWIITKSFPTDFYNGIENTLVDKWSIKRKSGVTLYPTKLPDSYMKGMDLIIYREVVDGRPQYRRIAALEE
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVKGHGKHQSKRFAGKKEKAPKISKYITRTQAIKRLNCTMEQFRKICILKGVSPRLPSKGLNTLTQKKTYYHIDDIKPLVNDKVTLKIKQIRAFKKHIRKLTARKEFKTKEQLLKTKPVIDLASTIQERYPTFQDALNELGDCLSMVFMFASYRVSKGEKAEAVRLARRIAMEWEAYIKHTNALRKCFISYKGYFYTAVVYGIAITWMVPHQFAIEKNETVDFNVLHEFLSFYVVLMKFINYKLYTNAGLNYPPEITKINGVEFLGTVQLEPLQLQKETEVISKDQDVQELNEALKQVKGEGENLATEMLVNHDTGASVQVTSHFVQSSGSGLFSGMVFYIQREVPRHPVAFVIETLGGIIVDNVDDESITHQIGERGEHKNIEREFIQPQWIFDCVNENFILPCGEYTIGQKLPPHLSPYVNEEEEGYVTERRKQLDAIKNNTKYDYEEEQKKEEESKKIQVKDLESDFVDGLVEEMGEEKKGKAKAPSVSKEAKKAEQEKKRKMAVLSGKDRRIVMKNEMLERRQTKKVNKFKERLAKSKEQK
The following text describes a protein:
Function:
May participate in lipoprotein metabolism.
Subcellular Localization:
Secreted.
Sequence:
MSLLRCRQQTLPSLCLSVLFLACFVASMPTESLTPTPGPENSRWSLVRARVMEMVEPLVTRTRDRWRWFWGPRAIQGFVQTYYEDHLKDLGPRTQAWLQSSRDHLLNKTHSLCPRLLCRDWTQG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
Subcellular Localization:
Cytoplasm.
Domain:
The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient; The PDZ 1 domain participates in the interaction with the PID domain of NUMB, and participates in the isoform-specific ubiquitination of NUMB. The PDZ 2 domain of isoform 2 participates in the interaction with IGSF5/JAM4, other isoforms containing this domain may also interact with IGSF5/JAM4 (By similarity).
Sequence:
MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MNLKITINQQASISEKLIIANLEQLLIFRDNTFNKIDCDQQITLKDAVQISQILNDQGVLNYEGEINEQITTYLEACGLYSQGQGQFIKRTLQTKKINIPQQDFNNCYGKYDYIEQKFQNQINFFKQVDLKGNQETIDENELLNDGVEVKQVESCASKPRACANCTCGRKEMEEKQDKEQLLEQLKNNSVKGCGSCYLGDAFRCANCPFRGLPAFKDGEQVKVLQDDVFLKEKEETDQIKLENGKVKLMI
The following text describes a protein:
Function:
Transcription factor that is necessary for cell cycle progression from G1 to S phase.
Subcellular Localization:
Nucleus.
Sequence:
MKGSSRNKDHSTDGEGTGKRPKRKCLQWHPLLAKKIIDFSEEEEEDEDEEDIDKVHLLSTDGLEHDADETEDEDSSEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWSVLDPKEKQKYTDMAKEYKDAFMKANPGYKWCPPTSKPVKTQSSTVTNRKKLWAFPSESAKDLPSPKKLVKTEEMPQLNFAMADPTQMGGLSMLLLAGEHALTAQEVSNYLSHLILSLKGKTCPPELTKPCGTSALFQLAEVVLKPWGLIATGARLKVEESEKVKVKIEKSQKTKGHENVKTKTGELEENARCCLAANPGLNSTMLVGPDSTTAKDPTYCSQELALPTISTLGLSKPEKLKKKKKKNKLDRQALEKCTPKKACKKRQSSESDIESVIYTIEAVAKGDWGAERLMEVPCKKIRPSSTVKGNFLDTKSPKKKVKSKEKKALKEKCVETAKDSKPPDAVNVMENKEMPCEIPDNIKSEPLTPTEDVMLPSLPEQVKIEDSGCNKKAETCGSRKSERACKGALYKTLVSEGMLTSLRANVDRGKRSSGKSGSSDHEGCWTEENWAFFPVGTSGNKKLKKPKPKEEIILGLAKLEEEFEKKFNSLPQFSPVTFDRKSVSVPRKKKKVGNYSADQPKSNKVLYPCPSCMPMIVHAGENIAIFGYRSSSNVSFQLRHKKEPQKSNSYMSFLNASGSPATQEPLVGSQKRKARKTKITHLVRTADGRVSPVGEVLEEKPEEQLQSSLQKATTDIDFSEESLQNTQLEEGHSITSGMPSVSAFFSLAALAEVAAMENVHRNQRTTPLPCDGQPKEMSQAPVLISCADQ
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MVQFKNRYMVMEIFIDGEKELVGGDPKKILSSNNVSRAIKDSIQLNFGECGLALSLGSFQVKYLNALTKICIIRTSHVDHRKVWSAITMIRSIGNCPAMFNLLDLSGSIRTCKTAALKCEEMKFEQYIVAAGDHCPQDITDIMKESIDKINALES
The following text describes a protein:
Function:
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence:
MVATTQQKPEAEKKKVDDKKGKPEPKKEEMTEEDQKLEEDLNLLVQRLSEPDTSLYKPSLETMRSLIRASTTSMTSVPKPLKFMRPHYNKMKEIYTSIAAPEVKKLCADIISVLAMTSDERTDTINYRILGSHEPIGDWGHEYVRHLAMEMSEEWKKEGTSDARKAELLQLTQDIVSHHMKHNAEVEACDLLIEIERLDLLVTYVQEVDHQRVCLYILSCAPLTPDPDNIILIRTALQLYLKFNRYLEAVRCAIMVNDVPKVHEIFAKATDPLLRKQMAILLGRHQIFLDYEGAEDSDALSELNSNAHLYEYFHSLARELDIMEPKTPEGIYKSHLEHSRPFGNSSQPDSTRMNLAAALVNGFVNCGFGVDKMMAETEEASRWFYKNKEYGMLTAAASQGLIWRWDIDTGLAQCDRFLYINDDYIKAGTLLAIGIISSGIQDACDPASALLLDHVQSERPIMRVGSILGLGLAYANSKRETVTKNEERGVIFELKKVLSDQKPSATPEVKGLAGLSLGLILVGTADAEAAMEMLQALMDKSETELTDPNMRFLALGIALIFLQTQDKSDVFVESLRSLPDPFGAMVSTLVEVCAYAGTGNVLKIQKLLHLCSEHYETPVAEKKTTSTRAGRGNPSATPARAAAPGAAAGTATPAPTGTPAVVPGAPRRDGAAPSATPAAPGSADASATDATPAPPAKPDLSSQQAIAVLGIGLIAMGDDIGSQMALRMFGHLIRYGEPVIRRAVPLALSLLSVSNPQLNILETLSKFSHDSDPDTAHNAIFAMGLVGAGTNNARLVAMLRNLASYHYKDQVSLMLVRIAQGLTHLGKGTMTLNPWHSDRQLLSPSALASLLSICYCFLDANNTVLNSRQHYLLYTLVLAMQPRMLTTLIEDEMKPGSLKQLNVSVRVGQAVDVVAQAGKPKTITGFQTHTTPVLLAHGERAELANDECKFKFKKHKLDEILLSDIPVTPHLEGLVILKKNPEYQPVVVSSKK
The following text describes a protein:
Function:
Regulator of cell proliferation and cell survival of differentiated cells independent of cell division. Essential for imaginal disks formation. Not involved in cell polarity.
Miscellaneous:
MISCELLANEOUS: Its transcript shares the first untranslated exon with the alpha-Spec transcript, suggesting a common regulation. It was initially identified as a candidate for quantitative trait locus (QTL) that affects olfaction. However, given that the mutant used to identify this gene also affects the alpha-Spec gene, this result is unclear.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAELKASDTEMTKPEERHLLQLLAQLEKVPHHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTTPAPQQPQGRRSTPGSGAQFCSTPNRSGGGGAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPEEAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQSPVKSYVPSALEGLTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELGLKLDPLRHNKLAQRLVTSSSSVEGQFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIARSCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCNCNRNKADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MFQWKIPLACLLCICLAYCEITVDVKGVTKKFDHFWESTGLCPPDPKDKIYEFLQSDDEKFNVALIGALPNQGIKQVRIHWLLNLILTGPHGYNFTYLDNLLGFLTDRGLKPRFELMGSSEFLKSGEQFWRDLVHEIASRYIGKFGANEVASWKFELWNEPDLKNYNILKFALPEYLSYVAGCAEGLRVAFDGRGVSASLGGPAGLFREENHPLCWGLLQACSANSHCPIQFISFHRKGGGTAEGVLNGTLELLDLLHNKFPNLAEMPIANDESDIITTWSDSWEWRGDARYAAMVVKVIAEHYKSLTLSRKLKIELLSFDNGFLNYHPFYFTQRTLFARFQMNHTDPPHSQFIKKPVYVAMGLLALLGDEYLAGGCDSNDSMLTVLATRTSDINQSNVGILVAYADSDEVNIETIKSVRLRINNLSIGSRFVVYLLDNILTNPYRFWHELGRPVFPPKFLRQQLREHEGPYRLFVPTSVSTANLNIALNLTVPSVALIHICSKPSANPGPVTKLSISNVTRNEILLTWSDAKIDTKCIRTYEVEFEAKCANSLRFERVNTNDVIFLSYHHAPTGDGACETTIGRYRVRAVDYWDQPGIYSEIIDKTAGRRIELMNFTYQSGRKLIDISLVMSPKMSEKSARKAQKIILKSDKKKKRRRKESYAIYIYKVLKQVHPDTGISSKAMNIMNSYVNDIFERITMEASHLAQYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTNSSNA
The following text describes a protein:
Function:
Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
Sequence:
MSISISDSAAQRVSAFLNHRGKGLGLRLGVRTSGCSGMAYVLEFVDEINDDDIVFEDKGVKVIIDGKSMVYLDGTELDFVKEGLNEGFKFNNPNVSNECGCGESFNV
The following text describes a protein:
Function:
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by directly recruiting the SWI/SNF and RSC chromatin remodeling complexes to the histone genes in a cell cycle dependent manner. In cooperation with HIR and ASF1, creates a repressive structure at the core histone gene promoter and contributes to their repression outside of S phase. Involved in regulation of Ty1 transposition.
Miscellaneous:
MISCELLANEOUS: Present with 11100 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to the promoter region of histones HTA1-HTB1, HHT1-HHF1, and HHT2-HHF2,.
Domain:
The N-ter domain (residues 1-67) homodimerizes and interacts with H3-H4 independently of acetylation while the double pleckstrin-homology (PH) domain (residues 68-301) binds the 'Lys-56'-containing region of H3.
Sequence:
MSKLFLDELPESLSRKIGTVVRVLPSSLEIFEELYKYALNENSNDRSGRHKKPRIDVSSDLLKTDEISETNTIFKLEGVSVLSPLRKKLDLVFYLSNVDGSPVITLLKGNDRELSIYQLNKNIKMASFLPVPEKPNLIYLFMTYTSCEDNKFSEPVVMTLNKENTLNQFKNLGLLDSNVTDFEKCVEYIRKQAILTGFKISNPFVNSTLVDTDAEKINSFHLQCHRGTKEGTLYFLPDHIIFGFKKPILLFDASDIESITYSSITRLTFNASLVTKDGEKYEFSMIDQTEYAKIDDYVKRKQMKDKSMSEELKAKSKSKGQATDGTADQPSILQEATRQMQDEKKAGVFSDDDEENDQNFEAESDLSDGSGQESSDGAEDGEEAEEDDEEDDEEEDKKGQSALNRDNSFASINGQPEQELQYKEFKEPLELEDIPIEIDNDDDEDDEDGSGVEYD
The following text describes a protein:
Function:
Acts as a translational repressor. Can mediate repression affecting different steps in the translation process: cap-driven, IRES-driven, polyadenylated RNAs or nonpolyadenylated RNAs. Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Note=During early cleavage and blastula stages found close to the cell periphery in a germ plasm-like pattern. From gastrula stage on, detected predominantly in a perinuclear region.
Domain:
The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Sequence:
MDGGLCFDSWSDYLGLSSLISRGLQPQREGERPRWDVLSPASAEPLPSNESVGHKGCGFCRSNREALSLYTSHRLRALDGRVLCPVLRGYTCPLCGANGDWAHTMRYCPLRRLLRDPQSNSNNPKLRH
The following text describes a protein:
Function:
DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.
Sequence:
MSPKRPQETPTLFAAAGLDHEAPHPLPDRLRPRALSEVVGQDHILGPDGALTRMLETRTLGSLVFWGPPGTGKTTVARLLADATDLHFEQISAVFSGVADLKKAFDAARARREMGKGTLLFVDEVHRFNRAQQDSFLPVMEDGTVVMVGATTENPSFELNAALLSRARVLVFRSLDAAAIEKLFAHAEEVEGKKLPLDAEARAVLVRMADGDGRASLTLAEEVWRSARADEIFNAAQLQDILQRRAPIYDKSADGHYNLISALHKSVRGSDPDAALYYLARMLDAGEDPLFLARRVVRMAVEDIGLADPQALVIANAAKDAFDFLGHPEGELAIAQAVVYLATAPKSNAVYTAFGAAMQTAKQAGSLLPPKHILNSPTKLMKSEGYGAAYEYDHDAPDAFSGQDYFPEALGRQTFYDPPERGFEREIRKRLDYWAKLRKERGGSR
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEAASAQHAEEIRRILLNRHLDAVFSSTGPRRPGSAPPQAEVLPGSPMGPPAVNLITGEPFGRAETEVKALVPAPVTHAKAPDTGGLGLPPEAEEALRSQPDYQQFYYANVRNNPRLPPPLPARGSWANNGKEDPGKADEAQAQATFNLLFGAQLNLKDGGADPIPIRPTANFLGQDLGTQLGTSLGAGSTGLSPPTHPPDTIAAAWANVGSASAAGSAAQQLDSLLGAFGSPKPGAGPMGLSPLLTELRAQASGASLYSARSADEQTLHDSLYLGSQPHTPLGGSQHGGLTVNVAPGGPTGQAPHPLFGSFNPDSPRPPSMDAVGRSTSSNSLGGNSFKDRGPQGRLASVIGGERSTVRTPSKLRMATTAAAAAVAEHDAQQQLLNSLTGADTAAAAAAAAAAAAAADPDNPAAAAAAAAAAQQLVSATQMQAAVEAFQNLPPAAASAFAAALGDQSGGGVGAQQLMAPDVYLGGGGVQAAAQSQHMQAQAQAAQAQAAQAQAQAAQAQAAAMYMAAMYGPAALGHMGNPMAGVGHVAPLSSQAAAASMYYAQQQAQSLQAMQAAALASASGFPGAGMPGLVGAGGFGPNAVAAAMLGGMSPAAAAAAGLDMAALAGGGMPGVGLVRPQGPGHFPGAGSGGGGGGMMMMGGMGGAGPGGGGGSANAEYAAYYQKMMEAQVVAMGLVGVGGSVSKEAEAAAAAALMRAGVPPPPPGPPGVKVKRDSGGEPPYGHGYGSDGGMGRAGSGGRGNVSAGRDGERMGMRGGGPGSPMAGGGIPGSPTHGAAGPFGPGPGGPPPNSRLRAATGPGGYQQGGDYGGGGGGGGGPNSASGMAQLPREGRDARGSNDGPHPQRRHSQRREDNGDPSSAGSAGGAGHGAGGRAPRSSGDTLLDEYKNNKTGRKYELREILGHVYEFSLDQHGSRFIQQKLEGVAAEDLEAAFAEVLPRILHLMTDVFGNYVVQKFLEHGTPEQRLKLGRALHGHVLQLSLQMYGCRVVQKALETFPEEAQMELVTELDGHIMRCVRDQNGNHVIQKCIECVPTHRIAAVLDNFLLCVVPLSTHPFGCRIIQRILEHVKDARRRSAVMSDILAAAVQLTQDQYGNYVIQHVLERGTPEERASIAASLASSVVPLSMHKFASNVVEKCLTYGSTADRDLLVSRMLGAHGVALQLHQQAHMGGGGGGLEGEEVEDPVQAMMKDQFGNYVVQKVLEVCSDEQREVMLARVRQQLHALKRYTYGKHIVARVEKLLSAGTRYQTHAKGRMLPDDEALAAAAAAAGGGGGRLGAVSGAGAGPSTSGMLPLPPLSPDPGAGASASSSSTASQSLNNSVSGETTAGGEAAAASRGGTASGQAAEGAAALTGVSESGGGAAGAGGAAAGDTAEAVAVSGSGGGAAPEQPSV