lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Leghemoglobin that reversibly binds oxygen O(2) through a pentacoordinated heme iron (By similarity). In root nodules, facilitates the diffusion of oxygen to the bacteroids while preventing the bacterial nitrogenase from being inactivated by buffering dioxygen, nitric oxide and carbon monoxide, and promoting the formation of reactive oxygen species (ROS, e.g. H(2)O(2)) (By similarity). This role is essential for symbiotic nitrogen fixation (SNF) (By similarity). Maybe involved in water stress tolerance.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MGAFTEKQEALVNSSFEAFKANLPHHSVVFFNSGSVHNSVFGLIKKQNNRILEKAPAAKNMFSFLGDAVDPKNPKLAGHAEKLFGLVRDSAVQLQTKGLVVADATLGPIHTQKGVTDLQFAVVKEALLKTIKEAVGDKWSEELSNAWEVAYDEIAAAIKKAMAIGSLV
The following text describes a protein:
Function:
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
Miscellaneous:
MISCELLANEOUS: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
Domain:
Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
Sequence:
MKVYLVGGAVRDQLLGLPVKDRDWIVVGADPATLLSLGYQQVGKDFPVFLNPKTKEEYALARTERKSSAGYTGFICDFSPTITLEQDLIRRDLTINAMAQSEDGEIIDPYGGKQDLENRILRHISPAFSEDPLRVLRVARFAARYHSLGFKIASETLALMAELAQSGELQHLTAERIWLETEKALNEKNPEIYFETLHKTGALSVLFSEIDALYGVPNPVKHHPEVDSFIHTMLVLKQAVNLTENNPILNKSAVRFAAICHDLGKALTPQNILPHHYGHEQAGIKPTRSLCKRLKVPSYFQELAELTCEFHTHIHKAFELRAETVITLFNRFDVWRKPQRFQEFLQVCLADTRGRTGFETKDYPQIDYINQLLHAANEVDVQQVIADGFEKQAIKNELTKRRILAVKQTKTNYPTN
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATKTAGVGRWEVVKKGRRPGAGAGAGGRGGGRKRRALGEANGVWKYDLTPAIQTTSTLYERGFENIMKRQNKEQVPPPAVEPKKPGNKKQPKKVATPPNQNQKQGRFRSLEEALKALDVADLQKELDKSQSVFSGNPSIWLKDLASYLNYKLQAPLSEPTLSQHTHDYPYSLVSRELRGIIRGLLAKAAGSLELFFDHCLFTMLQELDKTPGESLHGYRICIQAILQDKPKIATANLGKFLELLRSHQSRPAKCLTIMWALGQAGFANLTEGLKVWLGIMLPVLGIKSLSPFAITYLDRLLLMHPNLTKGFGMIGPKDFFPLLDFAYMPNNSLTPSLQEQLCQLYPRLKVLAFGAKLDSTLHTYFPSFLSRATPSCPPEMKKELLSSLTECLMVDPLSASVWRQLYPKHLSQSSLLLEHLLSSWEQIPKKVQKSLQETIQSLKLTNQELLRKGSSNNQDVVTCDMACKGLLQQVQGPRLPWTRLLLLLLVFAVGFLCHDLRSHSSFQASLTGRLLRSSGFLPASQQACAKLFSYSLQGYSWLEETLPLWGSHLLTVVRPSLQLAWAHTNATVSFLSAHCASHLAWFGDSLTSLSQRLQIQLPDSVNQLLCYLRELPLLFHQNVLLPLWHLLLEALARAQEHCHEACRGEVTWDCMKTQLSEAVHWTWLCLQDITVAFLDWALALISQQ
The following text describes a protein:
Function:
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (Probable). Involved in the regulation of flowering. Represses flowering under long day (LD) conditions. Regulates the trimethylation on histone H3 'Lys-27' (H3K27me3) of the flowering regulators MADS14, MADS15, RFT1, EHD1, HD3A and LF.
Miscellaneous:
MISCELLANEOUS: Over-expression and down-regulation of CLF respectively, represses and promotes flowering in long day (LD), but has no effect in short day (SD).
Sequence:
MAGDSRNEPMFCEEGSSESGYVLCVIDSLKKKITSDRFVYIQKRVEENSIKLSPITLHSHNLSKNRQTSTSNSTDLVSNLLTKRKEDALCAVNSRESSPDESEGANCQDECSSTVIVGGNLSARNSVRPIRLPEVATLPPYTTWIFLDRNQRMQEDQSVLGRRRIYYDTNCGEALICSDSEDEAVEDEEEKKEFKDSEDCIIRMTIQECGMSDAVLETLARDIERAPDDIKARYEILQGEKPEGSSKKVSELNVKMEDVYGDKDLDAALDSFDNLFCRRCLVFDCKLHGCSQDLVFPTEKQAPLCSSDEGTPCGIHCYKLVSKPDAIMEIDSHLLVDVEEPTSDNLKDQIGSNKKKLGSSGQKTKSQQSESSSTARVSSESSESEVQLLSNKSPQHSPGLSKNKLGAKGGIKKSTNRRIAERILMSVKKGQQEMSPDSNSIVNGCHWPRDMKLRSDTRSGIKDSVVSSQCNSPSTRSFRKKGTLQMENNSSFVDAQSDSMEDTNNEHSATDGCDSSRKEECVDESICRQEAHGRSWKVIEQGLLLKGLEIFGKNSCLIARNLLGGMKTCTDVFQYMNYIENSSASGALSGVDSLVKGYMKGNELRTRSRFVRRRGRVRRLKYTWKTAGYHFIRKRITERKDQPCRQYTPCGCQSACGKQCPCLTNGTCCEKYCGCPKMCKNRFRGCHCAKSQCRSRQCPCFAADRECDPDVCRNCWVGCGDGTLGVPNQRGDNYECRNMKLLLKQQQRVLLGRSDVSGWGAFLKNSVGKHEYLGEYTGELISHKEADKRGKIYDRENSSFLFNLNNEYVLDAYRMGDKLKFANHSPDPNCYAKVIMVAGDHRVGIFAKERISAGEELFYDYRYEPDRAPAWARKPEGPGAKDDAQPSTGRAKKLAH
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MDLPPFEVPVDQKHTHNHPRRMDCFFKDPRLLKQQQQQKQTTTQQQQQQQQIRIKTLQSNQQPLPKRIKLNHQQQTATGTNQTTTTTKKSIHSKPQLNNTQQSDQLSKTRETKPLVNQTEDNHHKTQEINNNNTTQDINQTQDINKTQDIKKNQNNNTTQNNFNTQDKQPQDDQNQTNKNPTTNHQDYQLHPIIPRSVDKTITAYSSNHPLNVEPAERKLTSSAKLVNANRNQFKPWFTNQDPQRWPFKKNQDPKIRVGYPTGAHELFRLLVPKNDLDEYRPLDDLLNVITTTLTYYLTPDQSLHFFSEPHPITSPSASVPHSQLNDFSFLNRRSQERSSPEPGRSTTPKIPLSDASLDLSSKPLLKELVKTIRRKNGPEFLGLVGWYNRVIKYLVEGKEIGRQIGSFVGMPQGVWETILGQAYDRQVGPQLELLQGYETWSSNVYGELKPRFVSEIIRLVGLRPGMVFLDLGSGIGNIVLQVALEVGCVAVGFEIMDGCAKLANLQRSELVGRAHSLWGVNLGAPLLFQADFTKDPRVGQWLQQADVVLVNNQVFTPSLNESLSLLFLELKDTAQIVSLKPFISSSFKLNQRNLDSPLAILSRPALRPTPPSTLVANSPGVFSYPSNSVSWTDNPGDFFVSVVNRDKLIRFQESFQA
The following text describes a protein:
Function:
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Sequence:
MALLEIKSTREIAKMREAGRIVATVLKEIMALAEPGLTTGDLDAHAERRCADFGVIPAFKGYHGFPACICTSINHEVVHGIPSAKRRLKPGDVLKVDFGAIYDGWHGDSCVTIGLEPLAEEARTLIRVAEEALLKGIREVRQGVHLQQVSGAIQDYVEGYGFSVVRQYVGHGVGRNLHEEPQVPNFRTREIPDPKLKSGMTLAIEPMVNLGHHATRTLADRWTVVTLDNSLSAQFEHTVLVTRDGYEILTDRSKV
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
Miscellaneous:
MISCELLANEOUS: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Subcellular Localization:
Cytoplasm.
Sequence:
MIHHPPAGARDLLPLEVAQKARINDQLQQTFHRWGYQRIVTSTLEWLDTLVAGGAISANNVIQLQDSGEGRLGLRPELTASIARAVVTRMTDNQPQRLCYRANVFRNPPEGYHGKQMEFFQAGIELLFAGGVRADAEILLLLTDCLTQLGLSDWQLILGDAGLTRSLLAKLPPTLQATVRDCITRLDYVELSQLPYPDNEAKNLALQLFDLRGTVEEVLARLGKLDLQGECLGLVDRLQALLCLVAASGDGPANLVLDLSWLQPFDYYTGMVFQAVSRQADNCYVLGQGGRYDQLLSQYHPQQQSFPGTGFSLNIEELHQCLLELGTLPTSTAPIDYLVCPVDDTAEGATFRHAQQLRRQHPDRRVELDLGGRSPEELNTYAQAMAVGQIVWVGADGPVDL
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MEEGVEEGEVGEYKLQRLVGQGSFAKVFRAAHRRTGARVAVKAIDRRRVEKRVHEGILKEREILKSIDHPNILRLLDTIDTTNMMYLVLEYCDGGDLDAFLHKHGRLPVATAKDLMRQLAEGLKVLRERNIVHRDLKPQNLLLSTNDDAIILKIGDFGFAKHENLAATICGSPYYMAPEIWQGKDYDAKSDLWSVGVILFQLVTGKLPYTGSTCFQLQQNILASDELNFPSEIEADLCPDCIDLCRRLLLRDPSEKCELVRESHHAVDLRDTCQAITSHVVLKTKPESVESKKSEVFDSWEWIEREYVLVPMNCTSMEMYSSVEKSAKDDTCTRNAGYDRTTGKGSVQNQNRDFIHRVIGVQNHGCTLVPVSQESANAEDRRAKPPDCFTRLHMLNQYVLVLTELAREKLSKGLYLEALSIELVLLAIWKEALDACSLFMDASDDGNFSESSPEHFLPKSDHSSLNVARGLDFSRPASVRSWVESGFMKAYDRAEKISHILRKSYDNTEMPDAMDVIFQTALEYGKSGAANEVLGHRSRSTALYSKSIILLTFILQEAPMLPLNPPFSISPSEQQRIHSYIANLKSHLCTAQVAGQQQRSAHN
The following text describes a protein:
Function:
May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
Sequence:
MSPKPRASGPPAKAKETGKRKSSSQPSPSGPKKKTTKVAEKGEAVRGGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSKGRPSTPLSP
The following text describes a protein:
Function:
May be involved in transcriptional regulation. May be involved in regulation of cell proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASLGLSTSRPRVVIQLERGEEPWVPSGTDTTLSRTTYRRRNPGSWSLTEDRDVSGEWPRAFPDTPPGMTTSVFPVAGACHSVKSLQRQRGASPSRERKPTGVSVIYWERLLLGSGSGQASVSLRLTSPLRPPEGVRLREKTLTEHALLGRQPRTPERQKPCAQEVPGRTFGSAQDLEAAGGRGHHRMGAVWQEPHRLLGGQEPSTWDELGEALHAGEKSFECRACSKVFVKSSDLLKHLRTHTGERPYECAQCGKAFSQTSHLTQHQRIHSGETPYACPVCGKAFRHSSSLVRHQRIHTAEKSFRCSECGKAFSHGSNLSQHRKIHAGGRPYACAQCGRRFCRNSHLIQHERTHTGEKPFVCALCGAAFSQGSSLFKHQRVHTGEKPFACPQCGRAFSHSSNLTQHQLLHTGERPFRCVDCGKAFAKGAVLLSHRRIHTGEKPFVCTQCGRAFRERPALFHHQRIHTGEKTVRRSRASLHPQARSVAGASSEGAPAKETEPTPASGPAAVSQPAEV
The following text describes a protein:
Function:
With TMN2 and TMN3, plays a critical role in the late stages of a nutrient-controlled pathway notably regulating FLO11 gene expression. Acts downstream of RAS2 and TOR. Essential for cell adhesion and filamentous growth. May play a role as effector of cellular copper homeostasis.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MIYKMAHVQLLLLYFFVSTVKAFYLPGVAPTTYRENDNIPLLVNHLTPSMNYQHKDEDGNNVSGDKENFLYSYDYYYNRFHFCQPEKVEKQPESLGSVIFGDRIYNSPFQLNMLQEKECESLCKTVIPGDDAKFINKLIKNGFFQNWLIDGLPAAREVYDGRTKTSFYGAGFNLGFVQVTQGTDIEATPKGAETTDKDVELETRNDRNMVKTYELPYFANHFDIMIEYHDRGEGNYRVVGVIVEPVSIKRSSPGTCETTGSPLMLDEGNDNEVYFTYSVKFNESATSWATRWDKYLHVYDPSIQWFSLINFSLVVVLLSSVVIHSLLRALKSDFARYNELNLDDDFQEDSGWKLNHGDVFRSPSQSLTLSILVGSGVQLFLMVTCSIFFAALGFLSPSSRGSLATVMFILYALFGFVGSYTSMGIYKFFNGPYWKANLILTPLLVPGAILLIIIALNFFLMFVHSSGVIPASTLFFMVFLWFLFSIPLSFAGSLIARKRCHWDEHPTKTNQIARQIPFQPWYLKTIPATLIAGIFPFGSIAVELYFIYTSLWFNKIFYMFGFLFFSFLLLTLTSSLVTILITYHSLCLENWKWQWRGFIIGGAGCALYVFIHSILFTKFKLGGFTTIVLYVGYSSVISLLCCLVTGSIGFISSMLFVRKIYSSIKVD
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MARPRVRRKIRNPSQKVSRKQKNRMDISFENAHPLVKDNWDKKKTLHQNYESMGLMVSLNGAAGGTGHEAADVVQEMMRVDKLKNDVEWRMLDDSPDSSVDDCSNTKTASTHKSSSSATLSKKTKPVGKFSVSKRSNSFQADQPELDLLDFTPIEAEIEVDSRTKRLGVKMSTRRMIEPTSPATSVNPIIATMQEEANNVVKLIRHTSSNEDLVYADLISKHGLDYEAMSKDLKLNRYQLTKGQLQRKIRTLVLVK
The following text describes a protein:
Function:
May act on an initial response of jasmonate-regulated gene expression toward drought tolerance as part of a BHLH148-TIFY11D/JAZ12-COI1A complex.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing BHLH148 display drought tolerance.
Subcellular Localization:
Nucleus.
Sequence:
MQMESYYGAFHADEAAFFFPHHVPASPELPFGLIASPEPEPEPEQAAAEARQSAFQEYGGAVHAGAPAAAGAVTTGGTNIHRRVMDVLGRMGGGGGGGEKGEGEEMEEEEEVPQRRRRGQGADVESSRGFRHMMRERQRREKLSQSYADLYAMVSSRSKGDKNSIVQSAAIYIHELKVARDQLQRRNEELKAQIMGHDEQQPCVTVQFEVDEPSSSIDSMIAALRRLKGMSVKARGIRSSMSGNRLWTEMNVETTIAACEVEKAVEEALKEVERNQPDSDAPFPGSKGWTQTSHVQNVF
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MPTRQQVAAQSISPVLFLTVDGEPMSFFLRPGPTKRQLQPKIKAGGGLMCSSQQPGAILLMDPKDRSSVSESDAHLYVSTQYILDCIEKEEQLSVEDYRFNPVDVPKKDRTKAACPRLSGGRLAYTSDDDTAILEYVSTRKAEIGGNRLWREMEQQRVTHHSWQSMKCRYKDRLAKKQPEVVKVESTEKQEGNKAEEDDTKDEEDLVLEVEIPAEAAVASPQKQSKESEKVCGTNADAHKSTSSRESGSESQQTDGPAEQSAPSQAMTVPASRCSTTEDPSAELPADAQPSSPDRDGPQPADIPTKQSLLQDSPPLQPESLPKAATPGKLKDKQEASPTLDRPMTRRKLELEVAAASPEHYGKKLRSSSSSAAASPQPSKKTTPVKAALQRSTETEQPLPKRARRNIAAAAAGETPAEQSETKAERKTTPADQSKSALQKDKKKPKRQLGILELATREFESECDEEDDPTVEDSAETVATSAELLPPPAETAADPRPTQPSPKTASSPNGNVPESSASSSNCVPDTCPSDPAAAKPAASEPAGVTSKAHLFIFDSESQGGDSERVAGDASAAPSNPQHSASKDASLSFTQVQLEEDKQRIKELMVQTQQDLVSVTKALLKTSGNFSAALDLLLNPSSLSVPIWSRRDDSLLLSADPVIRQQLQEKHGEEGVAKRMVFLEVEG
The following text describes a protein:
Function:
Sesquiterpene alcohol synthase that catalyzes the formation of the pheromone precursor (Z)-alpha-bisabolene from (2Z,6E)-farnesyl diphosphate.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MAARAPVHLRGFIARVALNKKNLHARHKLDTDIDKYYYTLHNVIIPDFMDMVKEIPGYPERIKKCVAHTTPSYFEGWAFSTELIYKTVADKQHQTERNLEKCRIIRALMDMSYAMAGILDDYVDKGEFRRGKKVWASVCEGGQEAAIYDSIAVTYLMSLMVKRHFGTDPGYSKLIELFNMVPGTAAIGNTLDILDRHDTNYYDDTMWKHSVQNKAANTVFPAATAGLIHAGVLCDDLLDRTSEVFGYTGHLFQVWDDFMEHYAVKEQSGKGAPDTKYNAKTWATLTAMAHFNEAQAKEFKACYGSTDPAKRSRVRELYDEVNLRGLYIDYLRNTYMVVEEKISKIPDPRIQSACRSYMDWLLVEPPQDEEEAESVLNN
The following text describes a protein:
Function:
Member of the two-component regulatory system PilS/PilR that regulates the expression of multiple genes including the type IV pilus (T4P) major subunit PilA. Thereby, plays a major role in the regulation of multiple motility pathways. Upon appropriate environmental signals, the histidine kinase PilS transfers the phosphoryl group onto PilR. In turn, PilR functions as a transcriptional activator by direct binding to a cis-acting sequence upstream of the pilin gene promoter leading to its activation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRQKALIVDDEPDIRELLEITLGRMKLDTRSARNVKEARELLAREPFDLCLTDMRLPDGSGLDLVQYIQQRHPQTPVAMITAYGSLDTAIQALKAGAFDFLTKPVDLGRLRELVATALRLRNPEAEEAPVDNRLLGESPPMRALRNQIGKLARSQAPVYISGESGSGKELVARLIHEQGPRIERPFVPVNCGAIPSELMESEFFGHKKGSFTGAIEDKQGLFQAASGGTLFLDEVADLPMAMQVKLLRAIQEKAVRAVGGQQEVAVDVRILCATHKDLAAEVGAGRFRQDLYYRLNVIELRVPPLRERREDIPLLAERILKRLAGDTGLPAARLTGDAQEKLKNYRFPGNVRELENMLERAYTLCEDDQIQPHDLRLADAPGASQEGAASLSEIDNLEDYLEDIERKLIMQALEETRWNRTAAAQRLGLTFRSMRYRLKKLGID
The following text describes a protein:
Function:
Cleaves presequences (transit peptides) from chloroplastic protein precursors. Initially recognizes a precursor by binding to the C-terminus of its transit peptide and then removes the transit peptide in a single endoproteolytic step. In a next step, pursues the cleavage of transit peptide to a subfragment form.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MASFPSPPLAAAAAAAPPRLAPGLPLAAAAVRRPSSLARRSSIALAAPANPLRCIHRRAVSPRLRRRTEAVGAASAAIGSLGEEREGCLSCFPRGRRRGRPGLARFAPCALPHTYGLSSLHSGLTGAKIRRRHVLHAAGPDEPHVASPTWSETALDKHYVDQPIGKEELEGFLNTPLPSHPKLVRGQLKNGLRYLILPNKVPANRFEAHMEVHVGSIDEEEDEQGIAHMIEHVAFLGSKKREKLLGTGARSNAYTDFHHTVFHIHSPTKTKEYGEDLLPSVLDALNEIAFHPKFSSSRVEKERRAILSELQMMNTIEYRVDCQLLQHLHSENKLSERFPIGLEEQIHKWDPDKIRRFHERWYYPANATLYLVGEINDIPRAIREIEAVFEHTLPEGEAAPMSTASPFGAMASLFAPKLPGGLAASLTGERSPAADKIKPVKRERQAIRPPVEHKWSLPGVAQDAKPPAIFQHELIQSFSINMFCKIPVNQVQTYKDLRSVLMKRIFLSALHFRINTRYKSSNPPFTSVELDHSDSGREGCTVTTLTVTAEPQNWRSAIKVAVHEVRRLKEFGVTMGEMTRYMDALIKDSEQLAMMIDSVPSVDNLDFIMESDALRHTVMDQLQGHESLLAVAETVTLEEVNTVGAEVLEFISDYGKPDAPLPAAIVACVPKKVHMDGVGETDFEIHPEEITDSIKAGLEEPIYPEPELEVPKELITQSELEDLKLQRKPSFASLSKEENVVKIFDDETGIAQRRLSNGISINYKITQNEARVGVMRLIVGGGRATEDSESKGSVIVGVRTLSEGGCVGNFSREQVELFCVNNLINCSLESNEEFIFMEFRFALRDNGMRAAFQLLHMVLEHNVWLEDAFDRATQLYLSYYRSIPKSLERSTAHKLMLAMLNHDERFVEPSPHSLQKLTLQSVKDAVMNQFVGDNMEVSIVGDFTEEEVESCVLDYLGTVSAPKSSKTQEHIEKISFLPFPSDLHFQQVYIKDTDERACAYIAGPAPNRWGFATEGNDLFNVIRSSSGDAQVSESANTDLTERKHNDVRSHSLFFGITLSLLAEIINSRLFTTVRDSMGLTYDVSFELNLFDKLDLGWYVIAVTSTPSKVHKAVDACKGVLRGLHSNKIVERELDRAKRTLLMKHEAETKTNAYWLGLLAHLQSSSVPRKEISCIKELTMLYESATIEDLYLAYEHLKVDESSLFACIGIAGAESGEETTDDELDMGLHGMGPIGGRGLSTMTRPTT
The following text describes a protein:
Function:
Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy; May activate Wnt/beta-catenin signaling to modulate epithelial cell function.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MESNLSGLVPAAGLVPALPPTVTLGLTAAYTALYALLFFSVYAQLWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCPVCLQFFTLTLMNLYFVQVVFKAKAKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSRQRQAQPWVLLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAIGGAMVLLYASRACYNLAALALAPRSRLDAFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRPPQDLSTSRILNGQVFGSRSYFFDRAGHCEDEGCSWEHSRSESTSMSGSLGSGSWYGAIGREPGWGGASQTRTTPLLFSQVPGPGSHHHSLYSTPQT
The following text describes a protein:
Function:
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Sequence:
MSDIVEKTLTALPGLFLQNQSVGGTAAAKASFSSRLGNLVRGITALTSKHEEEKLIQQELNNLKAMVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHENHELLLLLVNTVVKDLQSTNLVEVCMALTIVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKENSSAFKDLTGSFVTILKQVVGGKLPVDFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYGRYFISLAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLQQSKEEYIIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETENQQLRLYAVQSYLSLLDMENVFYPQRFLQVMSWVLGEYSYLLDKETPEEVITKLYKLLMSDSISSETKAWIIAAVTKLTPQAHSSNIVERLIQELTTSLDTCLRQHAFELKHLHGNVKFMKSLLPVNKSCEDMVVDASLSFLDGFVAEQLGQGAAPYKPHHQRQEEKLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDISGNSTETGLKEANSLKLEGIKKLWGKEGYLPKKESKTGDETEALPVPQDSIIVENVDQPITKKDQSQVITQSKEEKEKQLLASSLFVGLGSESTINLLGKADAISHKFRRKSKVKETKSGETTSAQHTTHSSFSSSSNMNYEDDYYLDNLQDRGDKELNKFSLNSKLLDSEPLTELPLVEKLSNCRLSTPSLFADNNMEVFHPPQSTAASVANEISLASSLLEETTEHMHSDLMEVCNDETVSVSFYKIWQDDCLLLVWSVFNKSGLELKSANLEIAPAENFKITEQPGCCLPVIEAESTKNFQYSMQMEKPFIEGTLSGFINYQVMDTHSVQLEFSVTLSLLDFIRPLKISTEDFGKLWLSFANDVKQNVKMSESQAALPSTLKTLQQELRLHVVDIIGSEGLLACQLLPSSPCLLHFRVHGDILALWFRSSCSTLPDYLLYQCQKVMEGS
The following text describes a protein:
Function:
Transcriptional activator which interacts with the mcb binding subunit complex formed by res2 and cdc10. Rep2 is required for the mitotic cell cycle start.
Sequence:
MHFADIPLSKPCLNNPPTYPWSSPILSSIANPSLCDIVSSPSSVSSFASSDDFAFMNAYCLPIQQNHQFGSPVAASPNQQPLVESQNRRNVTYASLVIGKLGIAQLIRQQTDPPQIIHRKQDKGLMARVLSRSKKQEERENHSSDARDAIKSALRRRMRRREGRVQKALRPTPNLICSKCNTTFNHSTALMMHEATCLNQVPFKLSDFFVEDVIDDWLF
The following text describes a protein:
Function:
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Sequence:
MAYTAKIGPSILSSDLSQLGRECERMMECGADYLHLDVMDGHFVPNITFGHPMVECLRSCIGPDPFFDMHMMVSRPEQWVKPMAAAGANQYTFHLEATSNPGNLIKEIRESGMKVGLAIKPGTTVEELAPWAGQIDMALVMTVEPGFGGQKFMEDMMPKVSWLRGQFPSLDIEVDGGVGPDSIHRCAEAGANMIVSGSAVVSSDDPRSVIALLKNVVMEAIQKRSLDR
The following text describes a protein:
Function:
Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport.
Sequence:
MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKSEPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLISREWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQHTVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSANAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKLILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVSSMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETFEKASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYSEVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQSQTRDFTGGTGSRPRPALLPLDLLLKVPPHMLRAHIKEIEAELVTGWQSHSLPAVILRNLKDHGPQMGTFLWQASAGIAVSQRKVRQISDPIQQILIQLHKIIYITQLPPALHHNLKRRVIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTSIELEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNHPTKR
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEFQAVIMAAGRGSRMTDLSNNIPKALLPIGNHPMIWYPINMLEKAGFERVIIITLESVGKDLRQKLKSCGEIKLELDIVTIPNDEDWGTAESLRHIRDKIKTDVLVISSDLITDIELHLLADIHRKYDSTITTLLYQQADQGLEGMTVPGTRTKKKSDQRDIIGLDEKGQRMLLMTAEADVEVSLGLKMSLLRKFPCIQFETRLLDAHMYFLKKWVVDFLADSKQGRNLTTLKGEVLPYLVKKQFSRISHASKADDKDSAIINVKQDGQLDLSQYLPYDELSKKSLEMSPWNAHKGEMSRVYQKGDSLRCYTYIASSGMCLRANNVAAYCEANRQVTAQKHLLGDEPLIHPSVNKSKSSGDGKSHSSIGKDCMVGERSSIGDQVSVKRSIIGRHCTIGDKVKINNSVIMDHVTINEGCVIQGTILCPNAHVNKNVDLKDCIVGASQNVVEGASYNGEVIGEGDMMMEI
The following text describes a protein:
Function:
Does not have a carbonic anhydrase catalytic activity.
Sequence:
MADLSFIEDAVAFPEKEEDEEEEEEEGVEWGYEEGVEWGLVFPDANGEYQSPINLNSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLSGGPLPQGQEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQMQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAFQ