lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Note=Constitutively associated with membrane rafts.
Sequence:
MTTPRNSMSGTLPVDPMKSPTAMYPVQKIIPKRMPSVVGPTQNFFMRESKTLGAVQIMNGLFHIALGSLLMIHTDVCAPICITMWYPLWGGIMFIISGSLLAAADKNPRKSLVKGKMIMNSLSLFAAISGIIFLIMDIFNITISHFFKMENLNLIKAPMPYVDIHNCDPANPSEKNSLSIQYCGSIRSVFLGVFAVMLIFAFFQKLVTAGIVENEWKKLCSKPKSDVVVLLAAEEKKEQPIETTEEMVELTEIASQPKKEEDIEIIPVQEEEGELEINFAEPPQEQESSPIENDSIP
The following text describes a protein:
Function:
Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTDLNLTSLLNGTESDLNNQTRCSLTKTGFQFYYLPTVYIMVFIMGLVGNSLAIWMFVCHMRPWSSISVYMFNLALADFCYVLSLPFLIFYYFNKTDWIFGDVMCRLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVITSMLVWVVVIVGMSPILYYSRTGPKGNSTTCYDTTTKDELPGYFIYSMTLTVFGFCVPFIIIFCCYGMIVKSLICNDMNNAPLRQKSIHLVIIVLAVFAISYLPFHVMKNLNMRARLYFQSPDMCEFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRKLSRATKKASRKGDNVLQSKSEETALNSLAEYVENGERRL
The following text describes a protein:
Function:
May function as a transcription factor downstream of MPK1 that is subject to activation by the MPK1 mitogen-activated protein kinase pathway. Binds to the DNA sequence 5'-CTA[TA](4)TAG-3'. At least some RML1 target genes are involved in cell wall biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGRRKIEIQRISDDRNRAVTFIKRKAGLFKKAHELSVLCQVDIAVIILGSNNTFYEFSSVDTNDLIYHYQNDKNLLHEVKDPSDYGDFHKSASVNINQDLLRSSMSNKPSKSNVKGMNQSENDDDENNDEDDDDHGNFERNSNMHSNKKASDKNIPSAHMKLLSPTALISKMDGSEQNKRHPENALPPLQHLKRLKPDPLQISRTPQQQQQQNISRPYHSSMYNLNQPSSSSSSPSTMDFPKLPSFQNSSFNGRPPPISISPNKFSKPFTNASSRTPKQEHKINNSGSNNNDNSNYTQSPSNSLEDSIQQTVKARRKLSARPVLRVRIPNNNFSSNSAIPSEPSSASSTSANGNSMGSSQIMKENKTSRSSKISPLSASASGPLTLQKGNNGRMVIKLPNANAPNGSNNGNGSNNNNHPYPFGSGSSPLFSATQPYIATPLQPSNIPGGPFQQNTSFLAQRQTQQYQQMSFKKQSQTVPLTTTLTGRPPSTFSGPETSNGPPTGSLPSKFVHDLMSNSPNVSSISMFPDWSMGPNSAKPGNTNNPGTFPPVQTAVNNGNSSNISSTNNTNNNNNNNNNNSSNNNSNNGNDNNSNNSNNSYYSNNEDAPVNGAAISEHTTDGDSNNQSNSSTYDAAATAYNGNTGLTPYINTAQTPLGTKFFNFSTDISGEKNSSKI
The following text describes a protein:
Function:
Prolyl cis/trans isomerase with specificity for phospho-Ser-Pro bonds.
Sequence:
MASNQVRASHILIKHEGSRRKSSWKDPEGRIISNTTRDAAVSQLKSFRDDIISGKSKFKDVASRFSDCSSAKRGGDLGPFGRGQMQKPFEVATYALEVGEISDIIDTDSGAHIILRTG
The following text describes a protein:
Function:
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MKIPPIPHHGTIFHTSGSHKASAIFLDEELVITSGLIFSDNESLNQTVADATKNSSIVELGTELKEIFDLDFRVVRKQENVLQQQAARAYHIVHSHRVRECMETVLEGLHVCIGGDMKPVRLYAPLYASIVILSTNLAKCVSWNHIKTVIDRLRPTGSTGPKLLDEVVTVSTPFGDESFFNTLNVGHISNIFGDHECLLLLDTHLSSGCQGGAVYNRNMKLQGILIGSTFTHRNENVSFPLAISMEEIVGVALNRRNLCQSLPMALPVQAFRSVCMIDSQGCWGTGCAFELNGKRYIISCSHVLATDNITCVFNDQKTMHPKLIYKNPIFDSAYDIALMEATFEEAQSSNWFCQLANYIPRIGQRLYAVGFPVLKSLARGINFKPSIIPGRVTKYSEGLLFTDCSIQCGQSGGPIFDENGLLVAIAVSNFKSSVDNLIYNCHNMCVPVKDIYNTLERYSITRDKTSLDGLQADWNVRCKWKLKPPVILNKL
The following text describes a protein:
Function:
Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPGVYGGDEINALVIDAGHSSSRVGWAGEDAPRVVLPSYYGHTSITDDAIAELESQAAFATSSSSTVEPTERAEPVDGDETMADGQALSTSNGNGGAAATQEASDHRLRQARAKSASKTLRFSVDREKKRRRFVGDNELNLYRTNLEIAPIFDDDGMLADASAFAQLCSFGLDSLSCDASEHPLLLTEPAWNSRESREKLTELAFETLGSPAFYLANRSVLSSFAAGKPSSLVIDVGSTNVSTIPIVDGFILRKGIYRHNNGGEAINRALLYSLHHGRGATFAGVTPQYVIKSRSSVDPGTPANVVLRQERVQGASSSFRSYHINRVVNDFKESVAQVLEVPWDDQQAQFRSGRMYEFPDGYNDAFGVERLRAAEVLFTPALWNGVSSSESFGAVLHASSQPSSEAGAVNGGSVSAAGATSVAGGKAAIGLADMVLSSINAVDVDSRPSLYGNIVLVGGSSLIQGLSDRLSYELGVKAPNQKIKIHSPGNTTERRHSSWLGASILASLGTFHQLWISKQEYEEHGAAIVHARCK
The following text describes a protein:
Function:
Catalyzes the attachment of methionine to tRNA(Met) in the mitochondrion.
Miscellaneous:
MISCELLANEOUS: Present with 3120 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MQCRSIVHRLYSKVSHVTTPIFYPNAKPHLGHLYSSLLSDVYHRWQLFKGNLSFFTTGTDEHGLKIQCASESNGFDQPKKFVDKLYPEFVQLDKIYGINYTRFIRTTDPDHIENVMKLWELCLKNGYIYMGEHKGWYSISDETFYPESKVIKDPKNDGKYLNTESKNEVVYQSETNYFFRLSLFNKKIVDHIRKNPDFIFPASKRDQILKELETGGTLPDLSISRPSARLKWGIPTPNDPSQKVYVWFDALCNYLSSIGGIPSILSNATEVVSRHYSDKSNVKGQLLIPYPKEVQRNTIHVIGKDIAKFHTVYWPSFLLAAGLPLPRQIVVHGHWLCNGMKMSKSLGNVVDPIDMARYYGADIVRWFLLENSKLEEDGDFQEAKLYETRELLVSKWGNLINRCCGSKFNIERAVMKFSDKANFQFQEIFQNEPIVSERIENLAKLLNKSQEVFDEKIAIFQYPQLLRHVWSIINDANTLVQNSKPWERELDQQDNIIFLAMETSRILSILCQSIIPSLSQSFLDRIDVSKEKRTINYARLGSDKTYGKQSNKKGREVPLKKIPFRLQEEQTNMRS
The following text describes a protein:
Function:
Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINTPKEDDYETRITESKCVTILHKGFSASVRTILQSDHSLLASSWVSAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIKPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKHDVQVRAAVSSMCREAGLWSEWSQPIYVGNDEHKPLREWFLIVIMATICFILLILSLICKICHLWIKLFPPIPAPKSNIKDLFVTTNYEKAGSSETEIEVICYIEKIGVETLEDSVF
The following text describes a protein:
Function:
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Sequence:
MTTRDDCLALDAGDPLADLRQLFALPDGVIYLDGNSLGARPRAAVERAAEVVAAEWGEGLIRSWNSADWRGLPERLGDKLAPLIGARAGEVVITDTTSINLFKVLSAALRIQEEDAPGRKVIVSESSNFPTDLYIAEGLTDMLQRGYRLRLVDDPEQLPAAIDADTAVVMLSHVNYKTGYLHDMREVTRLVHENGALAIWDLAHSAGALPLDLHAADADYAIGCTYKYLNGGPGSPAYVWVAPRLRERVWQPLSGWFGHSRQFAMEPRYQPGEGITRFLCGTQPITSLALVECGLDIFARTDMQRLRDKSLALADLFIELVESRCERFGLTLVTPREHARRGSHVSFEHAQGYAIVQALIDRGVIGDYREPGILRFGFTPLYTRFVEVWDAVQALLEILQSEAWKEPRYQVRHKVT
The following text describes a protein:
Function:
Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione.
Subcellular Localization:
Periplasm.
Sequence:
MTQFITHKWLAALGLASSIAAFPALAAKDVVVAVGSNFTTLDPYDANDTLSQAVAKSFYQGLFGLDKDMKVKNVLAEGYTVSDDGLTYTITLRQGVKFQDGADFNAAAVKANLDRASNPDNHLKRYNLYKNIAKTEVVDPATVKITLKQPFSAFINILAHPATAMISPQALEKYGKDIGFHPVGTGPYQLETWNQTDFVKVKKFAGYWQQGLPKLDSITWRPVTDNNTRAAMLQTGEAQFAFPIPYEQAALLAKNKNLELVASPSIMQRYISMNVTQKPFDNPKVREALNYAINRQALVKVAFAGYATPATGVVPPSIAYAQSYQPWPYDPAKARELLKEAGYPDGFSTTLWSSHNHSTAQKVLQFTQQQLAQIGVKARITAMDAGQRAAEVEGKGQKESGVRMFYTGWSASTGEADWALSPLFASQNWPPTQFNTAFYSNKQVDSDLAAALKTNDPQEKTRLYKEAQDIIWKESPWIPLVVEKLVSAHSKNLTGFWIMPDTGFSFDDADLK
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MKAGKSERERSSRRRHRSGDALATVVVKQERLSPEPVAHRRPDAPAASPPPPAAESGSAGHRGSRARGASRSPAKKKSKSSGRRSKSPRTKRSRSPHYSTVKVKQEREDHPRRGREDRQHRELSEQEHRRARNSERDRHRGHARQRRSSDERPVSGQGRDRDSQILQAQEEERDFNNARRREHRQQNESAGAEAQEVIPRPAGNKNKEVPVKEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSELDRKEDEDEEEEEEMVSDSS
The following text describes a protein:
Function:
May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; Extracellular side. Cytoplasm. Note=Associates with unknown subcellular structures in the cytoplasm.
Sequence:
MAPPPPSPQLLLLAALARLLGPSEVMAGPAEEAGAHCPESLWPLPPQVSPRVTYTRVSPGQAEDVTFLYHPCAHPWLKLQLALLAYACMANPSLTPDFSLTQDRPLVLTAWGLALEMAWVEPAWAAHWLMRRRRRKQRKKKAWIYCESLSGPAPSEPTPGRGRLCRRGCVQALALAFALRSWRPPGTEVTSQGPRQPSSSGAKRRRLRAALGPQPTRSALRFPSASPGSLKAKQSMAGIPGRESNAPSVPTVSLLPGAPGGNASSRTEAQVPNGQGSPGGCVCSSQASPAPRAAAPPRAARGPTPRTEEAAWAAMALTFLLVLLTLATLCTRLHRNFRRGESIYWGPTADSQDTVAAVLKRRLLQPSRRVKRSRRRPLLPPTPDSGPEGESSE
The following text describes a protein:
Function:
Activates endogenous medium-chain (MCFA) and long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated. Is the main if not exclusive MCFA (octanoate, decanoate and laureate) acyl-CoA ligase. Required for efficient MCFA beta-oxidation inside peroxisomes. Facilitates the transport of MCFAs into peroxisomes by passive diffusion, by decreasing the intraorganellar MCFA concentration. Also esterifies LCFAs in the peroxisome matrix. The LCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Peroxisome membrane; Peripheral membrane protein; Matrix side. Note=Imported via the peroxisome targeting signal type 1 (PTS1)-dependent protein import pathway.
Domain:
The FACS motif is required for catalytic activity and substrate specificity.
Sequence:
MAAPDYALTDLIESDPRFESLKTRLAGYTKGSDEYIEELYSQLPLTSYPRYKTFLKKQAVAISNPDNEAGFSSIYRSSLSSENLVSCVDKNLRTAYDHFMFSARRWPQRDCLGSRPIDKATGTWEETFRFESYSTVSKRCHNIGSGILSLVNTKRKRPLEANDFVVAILSHNNPEWILTDLACQAYSLTNTALYETLGPNTSEYILNLTEAPILIFAKSNMYHVLKMVPDMKFVNTLVCMDELTHDELRMLNESLLPVKCNSLNEKITFFSLEQVEQVGCFNKIPAIPPTPDSLYTISFTSGTTGLPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQQLYDMCFLPLAHIFERMVIAYDLAIGFGIGFLHKPDPTVLVEDLKILKPYAVALVPRILTRFEAGIKNALDKSTVQRNVANTILDSKSARFTARGGPDKSIMNFLVYHRVLIDKIRDSLGLSNNSFIITGSAPISKDTLLFLRSALDIGIRQGYGLTETFAGVCLSEPFEKDVGSCGAIGISAECRLKSVPEMGYHADKDLKGELQIRGPQVFERYFKNPNETSKAVDQDGWFSTGDVAFIDGKGRISVIDRVKNFFKLAHGEYIAPEKIENIYLSSCPYITQIFVFGDPLKTFLVGIVGVDVDAAQPILAAKHPEVKTWTKEVLVENLNRNKKLRKEFLNKINKCTDGLQGFEKLHNIKVGLEPLTLEDDVVTPTFKIKRAKASKFFKDTLDQLYAEGSLVKTEKL
The following text describes a protein:
Function:
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Subcellular Localization:
Nucleus.
Sequence:
MTLTLPLNNLVNTSDIGAPAQLLTESPPTPLSKTNKKARKKSLPVSQPSVAVAEQVETVLIETTAENIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQTTEPTPTQVYIRTPSGEVQTVLVQDSPPATAATTSTVSCSSPALRAPHLSGSSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGEAQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLGTKGL
The following text describes a protein:
Function:
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
METGGRGAAVSGGRAAAGGCRRKARAAAGTLAADMDLHCDRAAEPPAAEPPSGKINKAAFKLFKKRKPGGTMPSIFGVKNKGDGKGAGLVRSRTHDGLAEALVLEGGRREEPRAGSGDGARPGPAAPRAAPGGAGSAAGASVAKSHSFFSLLRKNGRPESGRAEQADAGPAAGRQKRGLRGLLGGVRWRRKDRRPKDAAPAGRAGAPGELARPGSLTASLECVKEEAPAAAREPHRPGADARPEPAGCGDIIADPEDEAGPSCAKHAPGPGQPGPAKKPPGVVAYQGGGEEMASPAEADDSYVQEFWDMLSQTEDQGQGPQEGAATAAAAAAPEAQVPPETPKDARCAEGAKEASSVKRRRVQRIPAELQPKEEPKQPDKEPQEGVPNSDEGYWDSTTPGPEEDGARKVGLPRDSDSGDALYDLYAEPDGSPAALPAGEETSCLSRLKPVSPVTVTCPLRTPGSLLKDSKIPISIKHLANLPSSHPVVHQQPARSELPRTKIPVSKVLVRRVSSRGLAGTTLRAAACHDSAKKL
The following text describes a protein:
Function:
Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MLTITKRLVTTDVRSRILLSSLNGKMSDALALLRQQQQTSVDVELLHTMLARAAALAHADTIAYMWYQHVMPRRLPVEGRLLCEMAGVALYQDRLFLPAQFLQHYQAMNRDRRTSPEDELIEYELRRIKVEAFARGTMHSTALREKWKVFLQEMDTLPGQPPLRLRDFPQMTKAMGIALMQQDEQAAALALFGRQPLVIKNEWSLPLLLAGVLWHVPGPAQARRVLAEFRQSYRGLPLLDAELVIKRRGFEINT
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MKISITAPAKINLSLDALYKREDGYHEVEMVMTTIDLADRLYLERLDEDKIVLDVKAHFIPEDRRNLIYQAALLLKKRFDVKMGVRITIDKHIPVSAGLAGGSSDAAAALKGLNVIWELGLSIEELAEISSEIGSDIAFCVYGGTALATGRGEKISALPNIPGCWIVLAKPSISVSTPTIYKELQVDNVEHPDTQKMIESIKNGDLDGIFAATGNVLESVTLEKNPQVKRIKDRMLAFGAEAALMSGSGPTVFALIKQYSRAKRVYNGLRGFCEEVYMVRPWSEGENDTNINY
The following text describes a protein:
Function:
Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (By similarity). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin-mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation. In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules (CGs) at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Golgi apparatus. Vesicle. Note=Enriched in synaptic vesicles at the presynpatic vesicles. Detected in the Golgi apparatus of cultured hippocampal neurons. In cytotoxic T-lymphoocytes, localizes to intracellular vesicles that move to the immuno synapse (By similarity).
Sequence:
MSGSVAAGAAAGPVPPAQEEGMTWWYRWLCRLAGVLGAVSCAISGLFNCVTIHPLNIAAGVWMIMNAFILLLCEAPFCCQFVEFANTVAEKVDRLRSWQKAVFYCGMAIVPIVMSLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQADEEKLAETFEGEL
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MTDSVAEVVRMLNEPPFEKAFTLIGFDAITPIQLLQVFNDVLASIAPDHEMDIRSEDPEQTVVRFLSLLRVLKYKPNLGPAEFRQGLVAASRDVIYPALHWLLQRREELAKRAYLARYLMRVEVPADILQDETVGETNRRYLELIDMFKTTHQELEGMKSSNLSIAEIKNDIKAMETEQAQLTTRLNRLRTKTEGVDRRDELLAAARALRQEHERQELLEQQREDQVEQRSALEDKLHRVAEQLRQLRATAVTGGSEGLLARLEEETQMYAYLATDKLPTALAEKEEQVAANRRIVDGPALTGSDLDALQREIQERSRNINRMMEARLAKSGEDASDQLTVFRKQAAIIASKKSNMSEKLQDLQDELARLQKEYSGRRAALGTSGPRVPGADEFKAFVAKLRSKSTQYKEKRAQLNAMEAEAMLLERTAAILTARLDGVRAELTAVEAAQGVSGAFDAQERLEQVSMAKSEIDERKGEALDDISSMVDKLTQTIANKREELAPLVAELRNLRADKAKLQEEYDTKKADYDRVAGTLGATKAKEEKMVRAYREEINQDESRYHYLHAMIQQLQAQQRAAADEEERYINKKEGESMRQIYNKRIREQDTLSKHLRERQKEVEQNHDNNLKQLDMWADLDRIFQAKLDSSSDGATGGAGGAGAHADRLDGTENHLVL
The following text describes a protein:
Function:
Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in telomere capping.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MCSSINEGPYNSPTFGKSLSLKVDGGFNAVSINPSGRDIVLASRQGLYIIDLDDPFTPPRWLHHITPWQVADVQWSPHPAKPYWIVSTSNQKAIIWNLAKSSSNAIEFVLHGHSRAITDINFNPQHPDVLATCSVDTYVHAWDMRSPHRPFYSTSSWRSAASQVKWNYKDPNVLASSHGNDIFVWDLRKGSTPLCSLKGHVSSVNSIDFNRFKYSEIMSSSNDGTVKFWDYSKSTTESKRTVTTNFPIWRGRYLPFGEGYCIMPMVGGNNAVYLINLCDDDDSEQNKKTKLQPIYAFKGHSDRVIDFLWRSRHTCDGDYDDREFQLVTWSKDCDLKLWPISDSIYGKVNFDRGKRLEEKLPDYDYCSYNKEPENRENVQKNEFRRLRENFVTTSGLKKNKTNHITWLSGIRMNSATSQEDLFNETKIQNLGEEVSAIGHKFPKVVFEKISVSTRELCLTLNGPWSEENPDDYIFLRISINFPLNYPNKGDPPKFTIEENSNLTMSKRQEILSNLATIGQKYTDSNLYCLEPCIRFVLGEKVSLEDIEEGQEPLLNFDIADHIDFEELSSLDSSYSDSQNPENLSSQSDIESYKEALVFPDTSNQGLDFGRNLALDTTPVPNGCGSCWTATGELFCFFANEKKPEKKQNAIIKLSQKEAGVEKHPFKIEPQVLYDKEVDSSVITAADELKARPKRYVDTLGLGGGTNGDSRTYFDDETSSDDSFDSVADDWDDILRNDIIVRTKIPILRGNFKAFSSVHSESGKTVESTKKNKNLVISKNFSSLLSDRKELALEYLFMDATPEGFARNNALVAEKFDLDEISHCWQILSDMLIDQSDYDPYTTIWNNHPMGIKWFIKEAIVYFERQQNLQMLAMLCCVILSARRKKIPARYYGQELENMEGTIVFNDNESQNTSFWKGSDAFSTRSRSSTVTPNFYGNHLRGKNIHGGDNSSIRSDDHHARLRTHNTLNGSSKFTEPAQKQGSRAISSSPFHSRMPDIKVELLHDDIIEAYEQEDLLHLEVSDIPKFQTYIYQYSKLLFRWGLPLERVKILKVSTDFRSSYSSQGIPPNNNKKSPYNGVLTHWIENNEFGEEKFLARNCNYCDLRVTRSSFICGNCQHVLHSSCARIWWEIGDECPSGCGCNCPEMFDA
The following text describes a protein:
Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
Subcellular Localization:
Cytoplasm.
Sequence:
MPHQWMEGNLPVSAKCAVCDKTCGSVLRLQDWRCLWCRATVHTQCRPTLPPSCPLGPARVSVVPPTALHAIHDEAWEVVRPQASSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPRLGLRLFRHFDPFRILVCSGDGSVGWVLSEIDKLDMHKQCQVAVLPLGTGNDLARVLGWGSSCDDDTHLPQLLEKYEKAGTKMLDRWSIMAFERTIAMPKLSLTPGQPEGQLHTQITQYEDSLVTHLQNILQSDETSVILNSAKRLCETVKEFATQLSDSSLTRGDEQLGKKCDILQQKLDLLLATLTSEQLDAAHLDDAKTKQEDTDSEVSFDKAKTEKSEKDLSNFNFRKHRRTSRFMEREKDALMLRANSLKRAIRNLVEHTEQVVDEQNRQASSSLPTVKISLSTDLDKEESAKMDSLKVLPTIESGSSTDVSSCPSPTSSILTARLANISPMPDVRRDSTVEDPDLLTTLPVPPDFADSRRSSQVQPSSMVDIATEKILRETCSTLISIGNLKTNEPEVSHDKQRRESTKYDEEEKECSSILSAISNEEVSITSEILDQKSFCPRKNSDGEDLNGHICHIDSPETDTYPNSDALHGESLMDDISSMLGEVMYGYDQDSIENTYTDDTTLFTNDMADLKLERRMSAKRDSLDKKRRSSRSKLDEDTQFGFENRAFMSQHVYLDNKVESEPTRYCSLAQFVEGNDIARRSFKRRSTKMSKTEANVTRQSTLLEESEITPVGSFNNLNKLEKELSNVSTSTLKALELDKETEEEAPKKNKEDALEKLKAEMCVFPQVSVIVEPPSPVLTEEIRTERMVKLGVEIEIDSGSDLDLRKSDKLSTDVTTSNNSSSSNLLGIDNEQFMTRSPAATRRISCCSMLNPAEAAALAAAAATTSFYTDAEKKEKKDEREKENRKLPIINPLVRLPTWPNVSTGSGFISKCLLANADTLCAAVSPLIDPDETLLEGFYERCVMNNYFGIGIDAKISLDFHHKREEHPEKCRSRAKNYMWYGVLGSKEWLQKTYKNLEQRVQLECDGQRIPLPSLQGIVILNIPSFMGGINFWGGHKEDHIFLPPSFDDKILEVVAVFGSVQMAASRLINLQHHRIAQCQSIQINILGEEGVPIQVDGEAWIQPPGIIRILHKNRMQMLCRNRALENSLKSWEEKQRQSIAAQGKQRHSISHDKGRHSFTRQSMPSHEKSFLGVNFEKIRQHSFSGAVPVHHHEKTVTFVEKPITPIEPDILFTDEEHHLLLSFIECVTTLTKWIKILAISHSLEADLYSLAAKCDTCLENIHPNGKILEGPTLRTEFTKLVTAVKQLYEESCCLLHDRGDKLKLREDLENKLSASLANTEMELRKCVMYDKPQGSLVYLQPVQGDQSEHKRKGLFWLKFRTKGASSSQQQGGKKTSREVASWGTQEVATWLETLQLSEYIDSFVKNDIRGRELLTLARRDLKDLGVTKVGHVKRILQAIKDLTQGL
The following text describes a protein:
Function:
GDP-mannose transporter that may be involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSTNDEENGTVIEVKNVPEPSPETWYSVFLRQASVYGVAAGYCLSASLLSIINKWAIMKFPYPGALTAMQYFTSAAGVLLCAQMKLIEHDSLNLLTMWRFLPAAMIFYLSLFTNSELLLHANVDTFIVFRSAVPIFVAIGETLFLHQPWPSVKTWGSLATIFGGSLLYVFTDYQFTIAAYSWALAYLVSMTIDFVYIKHVVMTIGLNTWGLVLYNNLEALLLFPLELLIMGELKKIKHEITDETDWYSLQVVLPVGLSCLFGLAISFFGFSCRRAISATGFTVLGIVNKLLTVVINLMVWDKHSTFVGTLGLLVCMFGGVMYQQSTIKKPNATQEAKPQEQDEEQEKLLEMQENKESNSVDIKETLKSEEKL
The following text describes a protein:
Function:
Hydrolyzes ribosome-free peptidyl-tRNAs (with 1 or more amino acids incorporated), which drop off the ribosome during protein synthesis, or as a result of ribosome stalling; Catalyzes the release of premature peptidyl moieties from peptidyl-tRNA molecules trapped in stalled 50S ribosomal subunits, and thus maintains levels of free tRNAs and 50S ribosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKYLIVGLGNIGPEYHETRHNIGFMTVEALARINNAPPFIDGRYGFTTSFSIKGRQLILLKPSTFMNLSGLAVRYWMQKENIPLENVLIVVDDLALPFGTLRLKGKGSDAGHNGLKHIAAILGTQNYARLRFGIGNDFPKGGQIDYVLGHFTDEDRKTMDERLETAGEIIKSFCLAGIDITMNQFNKK
The following text describes a protein:
Function:
Involved in resistance to arsenic compounds.
Sequence:
MVSFITSRQLKGLIENQRKDFQVVDLRREDFARDHITNAWHVPVTAQITEKQLNQLIKGLSDTFSSSQFVKVIFHCTGSKNRGPKVAAKFETYLQEEDITSKFESCILVGGFYAWETHCRESNLKLIVSG
The following text describes a protein:
Function:
Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis. Positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation. Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous. May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability. Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy.
Sequence:
MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGDYLLVTAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPIGILITSYCELLQNKVPLLGSSTACIVVLDRTSHRLHTANLGDSGFVVVRGGEVVHRSDEQQHYFNTPFQLSVAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTELKKLKNSNYESIQQTARSIAEQAHELAYDPNYMSPFWQSGMNQRGAEPELQGAQSGERRQGCHSNCKRKQRFRRCRVTSLYLYF