lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Elongates the mitotic spindle by interacting with spindle microtubules to generate an outward force pushing spindle poles apart (By similarity). Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force, possibly generated by KAR3, that draws separated poles back together (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Note=Spindle microtubules that lie between the poles.
Sequence:
MPDHEVQTRKSRMLDDAQEELNITVAVRCRGRNEREIKAKSSVVVTVPDVTGSNEVSINTTDEVGIAAKMNSRTYTVDKVFGPSADQSLIFKEIAEPLFDDFMKGYNCTVLVYGMTSTGKTYTMTGDEKLYDGQLSDSAGIIPRIMFKLFDALEATDSDFLVKCSYIELYNEELKDLLDESHDSSKRLRIFDSSSMNHSSRASSQSNSPREPEVAHNGFSRRRQRPPPVKANRMSATKQQLSESGSGIYVQNVQEFHIINAREGINVLQKGLKHRQVASTKMNDFSSRSHTIFTIMLYKNCDGELFRVSKMNLVDLAGSENISRSGAQNQRAKEAGSINQSLLTLGRVINSLADKSIHIPFRESKLTRLLQDSLGGNTKTALIATISPAKINADETSSTLEYAAKAKNIKNRPQLGALMMKDILVKNISSELAKIKSDFLSTKSKDGIYMSHEHYQEIVNDLENCQTEIQESKRQIESLTSQNNLLLKDKKASQEVTELQNSKIKKLQSTIEYLYDKIERQHHNETELATTIHKLKEALHTMQGSLKSYETHELRLQNDIKEVLYQGITSYRESMNQHLEKVKVSMLDKNLSIKENINNITTIFDDTLKSVEANGSDMCDTLVKLIKETPSMYLKEFNETVSSLKSELSSYSNALTNKLTEISEENNHLREYLDQHLFKNSTQEVLDLRMESVYQKVKNDSDQLLSKLVSMVGAHVEESRTLMVNSMKDTVNEIIDNERSLFQPIRDRWIASCDNINQCDASHQNFEAKSTSGLDKLKELSDASLKSSEDAVNKAKHRTDSFHDFVQKLCCDQSLKKQMHDISDKHRMLEDHFDDNVKYFKESSKGFEDMDCSIKKIIHEMSPEVGDIKSVETLMERINARTFSPVRPTGKTPSRQVLKNAITSKASSRSMSPIKTLDTNVRIISPVKRGTIEFGAEGPPTKKVR
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Miscellaneous:
MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MTIAPMANDLEDFESLLEPDFDAKQFGNDLLKATNNNDTTILDLNTPLKKLNYDLHEIDSRIDQLMNSNPLEIIELIYKNEHVNSTIVGELKPSLGYMNMSYDRLKNQVLDPYERARKVQLALSKVYQTSFLLRGALLYIHLSNKLNALSKTAQLSTSTAINLASLHYQLEITLEENKNLKSLRKIKQLDQDIVSPNKRELITFLSLQMCKECLNSIKIKSNKEIISQLAYSLYLLSSQEFESAINKIVLSNVTMSSQILSKILNSIRMFPDAFNEVVEKGYNIYILETLLQNIKTDNVTNSSRSIAANKSRLGNLLSEYTSMKSKAGSGTPRDLFWSKVSSAFKKDFDISVNRGGPVGKSLLKNKDFIINTMKQSMKKSSDNSDYQSYLDVMLNSVSISLNK
The following text describes a protein:
Function:
Probable cell adhesion protein involved in gonadal cell migration.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Lateral cell membrane; Single-pass type I membrane protein.
Sequence:
MKKILPIIWLINLVSGSLSLEKKAPDLLGKVCAFGDFNADRNTDILVFANGTLTINYQETKLLDVLEASKFTPGTSFAISKPSLNADFVECSVGDFNGDSRLDVLVSIRDKDTEIYNHTLWTSEIEDEKEIFRPFHVAMLQQHAMAIDVSDDGWTDVLGFYPNGSMFCTGFNKEGKYNLLVNGCKHEFVAFPEKLNIYPGMPHLFVDLNSDLIADIVFMTKESDGSLFMSVWQKTKISWQFRDWVPKLTPAQYPFVGAPVVMDVDSDGELDILVPICREDECSHITQMASWSKTKLWGLVACDMQDYTVIKEPFSRVIFRVGEFSLDSFPDMVVIAQATRANTRPVIKVMDNAECTKCEKNGTRRFEIRAQENIQPKNMSLGVIKMGTFFDLLEDGSLDLLVEYEYGGQTRFGFIYCPDKGDTTFLKVQVFTGVCSDRCNPKSNEIGSSISMTGACASFSMTDGWGGSTQSVACQVPASSNRALYLPFLLYGLGRSPNFVDELNIAIPKYADRKEDWKHSLKQIVPNSRIIVLPPSDQYPHWTSRLYVTPSALIVQSLAVIALVCCMLLMVVVFLHYREKKEDRYERQQQSHRFHFDAM
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSEFEHVLLVNVLVVDEISNRVDHLEGNFRGPSPAFCLLFKLFTMKLTDEQIQGLLNHADSPYVRAVRLLLFFGAFLIVANRELSGNGILSRHKWAGDKDGSVHSRSSLASVHYFDTIFPRIPVPVARQIASHLERLKLPTTPQGTTGRHSSEETARRPPSVKAALSVSFGQRAPHRASTRDSSPVRRSLPPSNGNNNNNNNNNNTDDRSSRGQDRTREERDRGRDREVERERPRSRDSDYRDRGRDRRDRRDREERDKDRHSSRERENRDRDRHSSRERDRDWRRERRSRSRSRSPRRSPRRRSSSPGMKDSDKNGSAANAAISANLLKLRDVYGDASGKKLEENQAARVKDSSGEDVIRLGGSSWR
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSLKSPAGVYGTIPATTTTTTTTHFSQPLPTTATSLTFISRATSATQSVIATRRPWKELLNPSSFSCPCNYSEAMSRVKYNVNYFRVNYAMVVLSVLFLSLLWHPVSMIVFIVVFIAWFFLYFSRDGPIVLFNREFDDRVVLVVLGLVTIVALVLTHVGLNVLVALMIGAVVVGIHGAFRNTEDLFLDEESAAEGGLLSVVGSQPLRPTTTGYTRI
The following text describes a protein:
Function:
Catalyzes the cleavage of p-aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate.
Miscellaneous:
MISCELLANEOUS: Unlike E.coli, AbgB is not present in H.influenza and therefore the multicomponent hydrolase AbgAB does not exist in this form.
Sequence:
MNLDLNQLVKWHREFHRFPEIGWSEFWTTSRIADYLEDLDCFEIFLGKQIINPDFVRGRKQAVVDKGLANAKAYGANEKWLEKMEGYTGCVALFDSGKPGKTIALRFDIDCVNVTETRSPEHIPNKEGFASINDGFMHACGHDSHITIGLGVALWIAQNKDKLTGKVKIVFQPAEEGVRGAAAIAQSGIIDDADYFASSHISFCANTGTVIANPRNFLSTTKIDIRYKGKPAHAGAAPHLGRNALLAAAHTVTQLHGIARHGKGMTRINVGVLKAGEGRNVIPSSAELQLEVRGENKAINEYMTEQVMQIAKGISISFNVAYETEIVGEAVDMNNDVELIKLIEEISLEQPQINNVNSDYAFNASEDATILGRRVQEHGGKAIYFILGADRTAGHHEAEFDFDENQLLTGVNIYTSLVQKLLS
The following text describes a protein:
Function:
Ligand for the G-protein coupled receptor QRFPR.
Subcellular Localization:
Secreted.
Sequence:
MGVRVMRSRICVIGLLVLMLTQSEAYSFREKSWRTSPYYRQYGGYFRRRDGGDQAPSFTSTGNGEDVSNGLDDDAGIYLSDQAGDDGISPADKRSAMLQQLAQQLKNRPREKGGFTFRFGKRESRRSFGSD
The following text describes a protein:
Function:
Nuclear lamina-associated inner nuclear membrane protein that is involved in cell division, nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis. Involved in chromosome segregation and cell division, probably via its interaction with the nuclear intermediate filament protein lmn-1, the main component of nuclear lamina. Required to organize the distribution of lmn-1, nuclear pore complexes (NPCs) and chromatin in mitotically active cells. Together with lem-2, plays a role in baf-1 enrichment at the nuclear envelope in anaphase. Together with lem-2, involved in muscle cell attachment to hypodermal cells, as well as muscle cell location and sarcomere organization. May play a role in radiation-induced DNA damage repair response. May repress binding of transcription factor pha-4 with target sequences in pharyngeal cells.
Subcellular Localization:
Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus envelope. Note=Lmn-1 and mel-28 are required for its localization to the nuclear envelope. Remains in the nuclear envelope until mid-late anaphase. Recruited to the reforming nuclear envelope from telophase and throughout interphase.
Sequence:
MDVSQLTDAELRDSLKSHGVSVGPIVATTRKLYEKKLIKLSDGSINNQSNLNDSQFNEDSLIISSSPKKSPPQRVFQNVSAATAAATTSPESDSDDCEESMRYLTEEEMAADRASARQAQSNKGGFLGSTITFTILFVFIAVFAYFLIENAEQLKLVAETNPEDTI
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSWRKDQDERLDGDEGDEELDENDYKTQKDAVLFAIDVSKSMLKPPQNTGDKKADKDSALTAALTCAYQIMQQRIISQPKDMMGVLLFGTEKSKFRDDSGNGTGYPHCYLLSDLDIPGAEDVKKLKALIEDGDDEDEIMVPSKEPVIMSNMLFCANQVFTTNAANFGSRRLFIVTDNDDPHAGDKQAKSSAAVRAKDLYDLGVVIELFPISREDKKFDLSKFYDDIIYRNPAAEAGQSESPKTSKSGDGLTLLNSLISNINSKQTPKRSYFSNLPFELAPGLTISIKGYMPLNRQTPTRSCYVYEGEEQAQVVQSETAQVDFAARTVEKSELRKGYKFGGEHICFKPEELAELKQMGKKTLRIIGFKKRSKIPSWASVKKSIFIFPSEEQYVGSTRVFSALWQKLLKDDKVGIAWFVARENAHPVMVAIFPSGNPDDEEANTPYLPAGLWLYPLPFADDVRSVDHVTAPPRPADELTDQMRQVIQNLQLPKAMYDPRKYPNPSLQWHYKILQAKALDEETPDAMDDVTLPKYRQIDKRVGGYLAEWKEMLAKKANDLQNTRAFKREFEEDDERPAKRAKPSKKAASGGGGPANSNADLKKAFEQGTLGKMTVAELKDIMASKGISTAGRKAELVERLEQWVEENL
The following text describes a protein:
Function:
Histatins (Hsts) are cationic and histidine-rich secreted peptides mainly synthesized by saliva glands of humans and higher primates (By similarity). Hsts are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle).
Subcellular Localization:
Secreted.
Sequence:
DSHEERHHGRHGHHKYGRKFHEKHHSHRGYRSNYLYDN
The following text describes a protein:
Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) (By similarity). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF) (By similarity). Required for regulation of a stress response gene network, probably as part of the PBAF complex and perhaps acting in concert with histone demethylase jmjc-1. Binds to the ethanol and stress response elements (ESRE) in the promoter regions of hsp-16.1 and hsp-16.2, probably as part of the PBAF complex.
Subcellular Localization:
Nucleus.
Sequence:
MESRKRKSELEHYIDKLTDPPEKQRKMAEFYNSLRMFYKRRWNATLKLPHVQGVEVNLYRLYDTVMALGGWQKVAASDKWSDIAEMFGCKDDILCGDHAIKIIYMRYLSKFEQVETIGDVDDYVDNEMSRSRGRNATSFFATNECPISNNRMVQEYQHRDERGQIINEPDYARLTKSLISGLPNEIDFAMNVCMLLSHAGPKQLRICHAPTLLTLLVAHTGVYDEDDETMADMGKEWKRTTKHNFRDFWASSGVPLDMLMTFLDREIEAEYIDEDDQFFTGVSETFNVKDSRCWRLNQVTTIIRNLSFEPANRVTIVKTWPVMKFLIMCASCKWSPLYVAALDALSNLATDIDLTDKTLVYISQHAILRIITDGIFSLDKFKLVRSLEILTGLCGFEGNEAIICDWLNSATIAHIFEVVGVKDIMMCVYTLECLYQISEMGDTACDLISESPKAIQQLVSMATLEAVSFGPAGLAGMKVVEYQPSFTQGSNQQQNPHHSQGGHQLGHSNVRMGGLNHNQHHQQIGPPGAPGAAPMTVRQVIQNNLALQQVQRENLNREQYSTQSSQPHPPHTNVPPSPSILAHHSSGLVQQNGMKFDRRTGNLPVRPIAPSTNSGESQLEQLTEKWIRQNCVFEPAMSTPRGELYAAYVDDLRNLYHSMSGSLAMFSGVMKNLYPDVNFRMAQNGIMIVAQGIRLIRPHRLAPAASQSASESHPLMKKMLTSEPKEENGVLINGHAVQESGAERIIKTEPIRTDEPSVLIESQEQSVPKKQNDINGEETDEVELNSKIVTPEKKSITNGTVEVCQEPIQASKLFDENYANQIEGSEVSIEIREQFVNDTDNVKLESEKINGIICNGNSKVKKESMASRAAHIVAVAAACNGDLERMNVVSNGNDIEKEIEKETEKVEEETNEEKNKEVVETEVVDDAQESEKRKCVPPSSNPTDYMCDWDCCSIYYASPSHVLKHLSEEHVAEELRLLCRWNGCADPTPRNRWSLITHIQDSHCNEAQLKAASQKRKEGGGIAPVRGAPRAEVISRDINNHPGYAKNAAFDAIRRHAFNFLSRELTDEAEGPVTKSIRLTSCLILRNLARYSAEGRQKLRRHESHICWLALSRLESAHALSQLLSELHQAPAAEEEQQKMLSEVPSSASLSSMAGSSSQLPTVPDSPTSSVASAPMKESTSVSNKPTVHINRMLNFSSLNEKTPTSPQFTAGSSPHRHQPIQQHIPSQPSPLVQTTPVRAGAGI
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MIKRLVDIGAVKFGAFKLSSGLESPFYVDLRSVLGEPELFQWVIERYEAVLSGLEFDVIIGVATGGIPYASVLGYRLKKPMGYVRDEAKGYGTGRQIEGADVAGKRAAVVDDVLTTGKSVLNAIRAVRASGGEVAGVVVFLDRGQCGAEAVKREAGVYVYSVYKMRELLEELRPHIGEERYRSVLDYLSQWRC
The following text describes a protein:
Function:
Transcriptional coactivator that specifically associates with POU2F3. This complex drives the development of tuft cells, a rare a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
In the N-terminus possesses a conserved OCA domain for bivalent binding to class II POU domain-containing transcription factors and to an octamer DNA motif (5'-ATGAAAT-3').
Sequence:
MSEKPKVYQGVRVKITVKELLQQRRAHQAASGGTRSGGSSVHLSDPVAPSSAGLYFEPEPISSTPNYLQRGEFSSCVSCEENSSCLDQIFDSYLQTEMHPEPLLNSTQSAPHHFPDSFQATPFCFNQSLIPGSPSNSSILSGSLDYSYSPVQLPSYAPENYNSPASLDTRTCGYPPEDHSYQHLSSHAQYSCFSSATTSICYCASCEAEDLDALQAAEYFYPSTDCVDFAPSAAATSDFYKRETNCDICYS
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Sequence:
MALTREEVLKIAKLSKLSFEDKEIEKFQVELNDILKYIDMLNEVDTSKVEPLVYINESVNNFREKEEKPSLEIEKVLFNAPESAENAIVVPKVIGE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths. Has both exopolyphosphatase and endopolyphosphatase activities at different ratios depending on divalent cations by cleaving phosphate from the chain end and by fragmenting long-chain polymers into shorter ones, respectively. The limited digestion products are 1 and 3 P(i) residues. Also releases phosphate from dATP. dATP phosphohydrolase activity is about 7-fold lower than the exopolyphosphatase activity (Ref.16).
Miscellaneous:
MISCELLANEOUS: Inactivation of PPN1 leads to the inhibition of expression of both exopolyphosphatase PPX1 and high-molecular-mass exopolyphosphatase not encoded by PPX1; MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein. Cytoplasm. Note=The cytoplasmic form appears in the cytosol during the transition of cells from stationary growth phase to new budding on glucose addition and phosphate excess.
Domain:
The transmembrane domain contains polar residues that mediate the recognition by TUL1.
Sequence:
MVVVGKSEVRNVSMSRPKKKSLIAILSTCVLFFLVFIIGAKFQYVSVFSKFLDDRGDNESLQLLNDIEFTRLGLTPREPVIIKDVKTGKERKLHGRFLHITDIHPDPYYVEGSSIDAVCHTGKPSKKKDVAPKFGKAMSGCDSPVILMEETLRWIKENLRDKIDFVIWTGDNIRHDNDRKHPRTEAQIFDMNNIVADKMTELFSAGNEEDPRDFDVSVIPSLGNNDVFPHNMFALGPTLQTREYYRIWKNFVPQQQQRTFDRSASFLTEVIPGKLAVLSINTLYLFKANPLVDNCNSKKEPGYQLLLWFGYVLEELRSRGMKVWLSGHVPPIAKNFDQSCYDKFTLWTHEYRDIIIGGLYGHMNIDHFIPTDGKKARKSLLKAMEQSTRVQQGEDSNEEDEETELNRILDHAMAAKEVFLMGAKPSNKEAYMNTVRDTYYRKVWNKLERVDEKNVENEKKKKEKKDKKKKKPITRKELIERYSIVNIGGSVIPTFNPSFRIWEYNITDIVNDSNFAVSEYKPWDEFFESLNKIMEDSLLEDEMDSSNIEVGINREKMGEKKNKKKKKNDKTMPIEMPDKYELGPAYVPQLFTPTRFVQFYADLEKINQELHNSFVESKDIFRYEIEYTSDEKPYSMDSLTVGSYLDLAGRLYENKPAWEKYVEWSFASSGYKDD
The following text describes a protein:
Function:
Involved in osmoregulatory glycerol response.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRPIKKSRSLKLPKSILEEIGESDSSARRGKRNHNLPHREKRKFARISRGKNGYENRKITEEGDSKSSELNDDYLDAHRKSSTKKKSSQNKQAKESKLLDPIAFQHKIALEEDDREIAHLEKMLGIKSKDKSAHSKIDKEFGWLLEDLDQEIDDIGVPGTEDPSYGHSEDSEVSDDTGDHGSVDELESEREGNSGEEEEEFHGFESNSDEFHQPETKPIRMDPLKPAVPSLPNANVGSKYVPPSLRKKLGGDKESEDALRLRRKLQGSLNKLSIANISSIIKEIEVLYMENSRHSVTSTITNLLLQTVMGRESMLDQLAIVYAALATALYRIVGNDFGAHLLQTLVERFLQLYKSKEKEPLSSHKETSNLIVFFVELYNFQLVSCVLVYDLIRLFLRSLTELNVEMLLKIVLNCGGQLRSDDPTSLQDIVTEMNLLLASADPSTISVRTKFMVESITNLKENKKTKVANASAQSKFEAVNQLKKFLGSLGNRSLNAREPLRVTLEDIEQIETKGRWWLVGASWNNVPSGDNTLSTEALQDKKKSEELTAHSKILQAAKKLRLNSTLRTSIFVALVGSEDYIDAWERVLKLHLKRNQLPEIAYVILHCVGNEKLYNPFYGLVALKCCTLQHNLKKSFQFSLWDFFNELQPDDDSEEREISMRRIVNLAKLYASLVIEAAQPLTILKHVDFMAINAQMQTFLLVFFTDIILGVKDDLQLVKIFENCKAEKNLSSKVDWFLKTYVRKNPLVDNSKKALFKSNLAMASAILQSISKEEI
The following text describes a protein:
Function:
May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum. Binds hydroxyapatite and may promote the biomineralization of the cementum. Also promotes cell proliferation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the nucleus of some cementoblasts.
Sequence:
MGTSSTDSQQAGHRRCSTSNTSAENLTCLSLPGSPGKTAPLPGPAQAGAGQPLPKGCAAVKAEVGIPAPHTSQEVRIHIRRLLSWAAPGACGLRSTPCALPQALPQARPCPGRWFFPGCSLPTGGAQTILSLWTWRHFLNWALQQREENSGRARRVPPVPRTAPVSKGEGSHPPQNSNGEKVKTITPDVGLHQSLTSDPTVAVLRAKRAPEAHPPRSCSGSLTARVCHMGVCQGQGDTEDGRMTLMG
The following text describes a protein:
Function:
LEA proteins are late embryonic proteins abundant in higher plant seed embryos. The function of those proteins is not known.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEEQLQKPIDCADVKGEAEKISTTEGGIKAAEDKEKGVVAEASGEQAEGEVNQKKVVANPLKSEGTITIGEALEAAVLTAGNKPVEWSDAAAIQAAEVRATGRTNIMPGGVAASAQSAATLNARIGSDDTKTTLADVLTGASSKLPSDKAATRKDAEGVTGAEMRNDPHLTTYPTGVAASVAAAARINQSK
The following text describes a protein:
Function:
Rapidly hydrolyzes choline released into the synapse.
Subcellular Localization:
Synapse. Secreted. Cell membrane; Peripheral membrane protein. Note=May be secreted or membrane associated via a non-catalytic subunit.
Sequence:
MRYSLLFFIFLPCVITAVDLIHLHDGSPLFGEEVLSQTGKPLTRFLGIPFAEPPIGNLRFRKPKPKQPWRIPFNATTPPNSCIQSEDTYFGDFYGSTMWNPNTKLSEDCLYLNVYVPGKVDPNKKLAVMIWVYGGGFWSGTSTLDVYDGRILTVEENVILVAMNYRVSIFGFLYMNRSEAPGNMGMWDQLLAMKWVHKNIDLFGGDTSRITLFGESAGAASVSIHMLSQKSAPYFHRAIIQSGSATSPWAIEPRDVALARAVILYNAMKCGNMSLISPDYDRILDCFQRADADALRENEWAPVREFGDFPWVPVVDGDFLLENAQTSLKQGNFKKTQLLAGSNRDESIYFLTYQLPDIFPVADFFSKSEFIKDRQTWIKGVKDLLPRQILKCQLTLAAVLHEYEPQDLPISAQNWLNAMDKMLGDYHFTCSVNEMALAHTKHGGDTFYYYFTHRATQQTWPEWMGVLHGYEINFIFGEPFNQKRFNYTDEERELSNRFMRYWANFAKTGDPNKNEDGSFTQDIWPKYNSVSMEYMNMTVESSYPGQNRIGHGPRRKECAFWKAYLPNLMAAVADVGDPYLVWKQQMDKWQNEYITDWQYHFEQYKRYQTYRQSDSETCGG
The following text describes a protein:
Function:
Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P; (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
The conserved DXD motif is involved in enzyme activity.
Sequence:
MSKPPDLLLRLLRGAPRQRVCTLFIIGFKFTFFVSIMIYWHVVGEPKEKGQLYNLPAEIPCPTLTPPTPPSHGPTPGNIFFLETSDRTNPNFLFMCSVESAARTHPESHVLVLMKGLPGGNASLPRHLGISLLSCFPNVQMLPLDLRELFRDTPLADWYAAVQGRWEPYLLPVLSDASRIALMWKFGGIYLDTDFIVLKNLRNLTNVLGTQSRYVLNGAFLAFERRHEFMALCMRDFVDHYNGWIWGHQGPQLLTRVFKKWCSIRSLAESRACRGVTTLPPEAFYPIPWQDWKKYFEDINPEELPRLLSATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHEAMKMYL
The following text describes a protein:
Function:
May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cytoplasm.
Sequence:
MIATGALLRVLLLLLAFGHSTYGAECDPPCDPQYGFCEADNVCRCHVGWEGPLCDKCVTAPGCVNGVCKEPWQCICKDGWDGKFCEIDVRACTSTPCANNGTCVDLEKGQYECSCTPGFSGKDCQHKAGPCVINGSPCQHGGACVDDEGQASHASCLCPPGFSGNFCEIVAATNSCTPNPCENDGVCTDIGGDFRCRCPAGFVDKTCSRPVSNCASGPCQNGGTCLQHTQVSFECLCKPPFMGPTCAKKRGASPVQVTHLPSGYGLTYRLTPGVHELPVQQPEQHILKVSMKELNKSTPLLTEGQAICFTILGVLTSLVVLGTVAIVFLNKCETWVSNLRYNHTFRKKKNLLLQYNSGEELAVNIIFPEKIDMTTFNKEAGDEEI
The following text describes a protein:
Function:
Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASLDQEVMGIFSHSSVSVPVKDKKLLEVKLGELPSWILMRDFSPSGIFGAFQRGYYRYYNKYINVKKGSISGITMVLACYVLFSYSFSYKHLKHERLRKYH
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKDHNKSFVIVLIVLVGIFVAITVNALIRAKSWTITKPWDTHGFYCGFDNSKLVVKDAPNDFVKPNLVNYPYLYFDGNNITHQICVSKCPTEKGLPGLFDKIHIGQNRIGSYLDNKTYNAKYYPGARKVYKYKTRLVLNRCIPDLTIGGYMDLASSYSEDFEQISKIIPKYKATIDDLLKNKYMYLVSCAITLIIGFVWIMIQHDIVGYVIKFFVVLVPISLIGVGLFLFSPVVIMSPMISLFLLLFYSQLKIIAVIVWVIAALIIWFLVRIWRKLNLAISLINIAADAFYYNFTTIIFRILSTFIFILVSSIVLVSSVALYSIYEFKYNIPDDGFFKGIGRITFDWNIVTCMLIYNFVFLVFIYILLNQVSYYATSAVIVKWYFTKQIGNTRNGHISFHGIWLAWKKGLGTITISSLILTALHRYVMQVVKLFRNISLIVGLLLRFINWLLQCSCLLPIQHIFNTGWIQSAKLEHDFLVYDFLFSIIMRVTSNFIFWLSSLAISLISGFLMRYFEYKILGVQNPQIERLYLYSILNYFVLSCLTSTFYNIIHCVYACYEYEKSNPEYKDFLNHKMEHKITPEINEAPQNADASIKDSDEKLEDETKLKEE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MMCRTSFSEVLIEIGCACVCSWGECACVIECLRLLHTHTPRVLNSMAESHKRMRTSPGNGNAMVVVKKEPAQSPDAGQASSSSAQGSDGRDDTSATSIAAVKDANKLDCSECAAPLKTPIYKCEAAGHKVCSACRGSGNPCRACGSNNGAAASSYTRCGDDLDGLARALKVACPHKPYVCKKRVPCLDVDDHRLCCPDAPCSCSIPPCSGGFLGSPMAVHDHLTGPAHSWPRTVIDTDYRGKALQLGLTLSGPESRQLLVSKEDDSVFVLLAAAAAARVSLTCLRASAAAAAGPHYWAVLWAHATKDPVTGKVDRQQDEFTVQSRRSPREIGAGEDDGTLVSLKRKYLHGCGEEERKILLYVRIFKLKSPSASSSARRMLLVG
The following text describes a protein:
Function:
Participates in the host transcription shutoff by causing premature termination of transcription from host DNA. Acts as a site-specific termination factor that abolishes transcript elongation on cytosine-containing DNA but not on the 5-hydroxymethyl cytosine present in the viral DNA. Therefore inhibits as well transcription from other phages that contain cytosine in their DNA.
Sequence:
MDLQLITTEMVVEAYGDTTDGISVFKGNRRVGYITGLKKDLAKQVKRKTTIKEYRNRRLEQARDMLPDAVEEMKVFLENQLAKYDCEVFINQTQPNVHINSCKCYIIVNPLTGKHRLGISNPNRSASDMAEDVEACFKISKSPAEHHILINGLSQDDIVEVIKTLCM
The following text describes a protein:
Function:
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSAFLAMGGYGAYVWTAYALFVLVLLADLIAPWLRRRRLPAQLRGQLQRQAPRRPREQPVPVLERDA
The following text describes a protein:
Function:
May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Nucleus. Cytoplasm. Note=Also localizes to microtubules.
Sequence:
MASKFKQVILDLTVEKDKKDKKGGKASKQSEEEPHHLEEVENKKPGGNVRRKVRRLVPNFLWAIPNRHVDRNEGGEDVGRFVVQGTEVKRKTTEQQVRPYRRFRTPEPDNHYDFCLIP