lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAAEIDEGVFETTATIDNGSFGTRTIRFETGRLALQAAGAVVAYLDDDNMLLSATTASKNPKEHFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLRNEIQIVVTILSLDPGDLYDVLAINAASASTQLGGLPFSGPIGGVRVALIDGTWVGFPTVDQIERAVFDMVVAGRIVEGDVAIMMVEAEATENVVELVEGGAQAPTESVVAAGLEAAKPFIAALCTAQQELADAAGKSGKPTVDFPVFPDYGEDVYYSVSSVATDELAAALTIGGKAERDQRIDEIKTQVVQRLADTYEGREKEVGAALRALTKKLVRQRILTDHFRIDGRGITDIRALSAEVAVVPRAHGSALFERGETQILGVTTLDMIKMAQQIDSLGPETSKRYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSVEEFPYAIRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDIQVEGAVDGVVERRFVTLTDILGAEDAFGDMDFKVAGTKDFVTALQLDTKLDGIPSQVLAGALEQAKDARLTILEVMAEAIDRPDEMSPYAPRVTTIKVPVDKIGEVIGPKGKVINAITEETGAQISIEDDGTVFVGATDGPSAQAAIDKINAIANPQLPTVGERFLGTVVKTTDFGAFVSLLPGRDGLVHISKLGKGKRIAKVEDVVNVGDKLRVEIADIDKRGKISLILVADEDSTAAATDAATVTS
The following text describes a protein:
Function:
Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons.
Subcellular Localization:
Nucleus.
Sequence:
MMFPSLIAPPAVYPSLLRPTPTLTLPQTLQTAFSSHSSFLVEDLIRISRPASYLPRTVPPPSLSPPTSGTTTVMTDTVTSDLVSSSTSGSRRGCSPQTSASSTNESTFLKFGVNAILSSSPRTETSPALLQRVPPKTFSFPYFEGSFQPFIRSSYFPASSSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKERELLSNGGCREQTLPTKLNPHPDLSDVGKKCPGDEEEEEEEEEEEEEASHLRPASPRLPLAFFPSPEHRHRRDRLDNQMPPSPSHSSSPSKPSDFSDSEEEEEDEGEEEEITVS
The following text describes a protein:
Function:
Mediates the deactivation of rap1 during multicellular development and is required for normal morphogenesis. Also required for the correct patterning of specific subtypes of prestalk cells.
Sequence:
MFSHCEGYRIEGGVTDGETNWNNNFNQNNNNNDNNKVMASIYKQQFYGKPHKTFMSLSSPNGPILVCIKKVGNSSDDFYLLVCTEKGFEEVRANKDSLQKSKTTRSFLKMRPTSLNVITSVRPELTKVPLCKVTDKSIQEELVKVCEPEFNKVIKSALLYCKESQRDDNDMLKNISSNVSQEYNDFLNFLGEKVELKDFSKFNGGLDIKNNSHGTHSIYSQINDVEVMYHVATMLPFFPSDPKQSERRKLISLDRVVIIFNDGSKPMSPNCIKSKSTQIIILIQPIKNFVGNSKTTIGISNDENRVVGEQPSPSLTTTTTTTTTTSPTINSNSPTPSNKIKYRVSISNRDEVPNYGPPLPDPPIFEKDDSFRNFLYQKMVGGAASLRNTPAFTSKNSEKASALINVISKYSTKGMEQI
The following text describes a protein:
Function:
Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAAVGNAVPCGARHCGARPAGQPKPKPQPRTVLAAGPALIASGDELVAAVWPYRRLALLRRLTVLPFAGLLYPAWLGAAAAGCWGWGSSWAQIPEAALLVLATICLAHALTVLSGHWSVHAHCALTCTPEYDPSKATFVKVVPTPNNGSTELVALHRDEGEDGQEVLSFEFQKIKYSYDALEKKRFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKKFGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMSEIRKMGNKPHMIQVYRSRKWRPIASDEVVPGDIVSIGRSPQENLVPCDVLLLRGRCIVDEAMLTGESVPQMKEPIEDLSPNRVLDLQADSRLHVIFGGTKVVQHIPPQKATTGLKPVDNGCVAFVLRTGFNTSQGKLLRTILFGVKRVTANNLETFIFILFLLVFAIAAAAYVWIEGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVTPVSNIPIETHRALASCHSLMQLDDGTLVGDPLEKAMLTAVDWTLTKDEKVFPRSIKTQGLKIHQRFHFASALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMFAQCPPDYHHIHTEISREGARVLALGYKELGHLTHQQGCTCRIWRFLGWGSNQNCSCQPTPQLQQHQILNPLSEAKDGTCILMDASQAREVKREALECNLKFVGFIVVSCPLKADSKAVIREIQNASHRVVMITGDNPLTACHVAQELHFIEKAHTLILQPPTEKGQPCEWRSIDGSIILPLAPGSPKALALEHALCLTGDGLAHLQAEDPQLLLRLIPYVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAPERVIERRRRPRDSPILSNSGVRTTSRAAKQRSGLPPPEEQLASQRDRLSQVLRDLEDESTPIVKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKTLSRERPLPNIFNLYTILTVMLQFCVHFVSLVYLYSEAQARSPEKQEQFVDLYKEFEPSLVNSTVYIMAMAMQMATFAINYKGPPFMESLPENRPLVWSLAVSLFAIVGLLLGSSPDFNSQFGLVDIPVEFKLVIAQVLLLDFCLALLADRVLQFFLGTPKLKVPS
The following text describes a protein:
Function:
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAVARGQGFVLSRPVTFVTGNAKKLEEVKAILGQSIPFQSLKLDLPELQGEPEDISKEKARLAAIQVNGPVLVEDTCLCFNALKGLPGPYIKWFLQKIGHEGLNNLLMAYEDKSAYALCGFAFALGPNIEPITFLGKTPGKIVPARGPNDFGWDPIFQPDGYDQTYAEMAKEEKNKISHRSKALAMVKSHFAEAGYTFQMDTST
The following text describes a protein:
Function:
Responsible for methylating the 5'-cap structure of mRNAs.
Sequence:
MDRIAYHPIRVSPHASLFLPLSEQELKIYQTECVNTLRVPSGSDPNLSRSQPPDSHINTNDKESAIQPSPQLEQDIGSPVGYTTPSPLSIPISSFPAAQYPHESYPPQTSSTNKRSLQSPTEYNQSGAASSSMPHFPKRTRHNHSPHHSLNNDSHNSISETVAQHYNMRPNLTKGARTESPIFGLRKFNNWVKSVTIGKFASVESSFMAPLLSYNNHPQQQQQQYPHQHHPHPKSNGTKILELGCGKGGDLAKWQNAGVRELFGFDIARVSIEQAQSRYQENCSQRFYAKFVALDCFSLPISSVLSPEELREPFHAVSLQFCMHYAFESEVKARTMMENVTKYLVTGGVMIGTIPDPDLLIQGWERCSRESNVDKPSFGNSVYQIRFPYPLSPQRSELNQVYGNRYSFYLEDAVEDIPEYLVLWEPFVRLAQEYGLKLVYKKGFHELFQIERANPSYKNLLYKMRVTNSEGNLVIPNDQWEATGIYSAFAFVKI
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MENIGSGRGRTFQIAGSRLPDCMHACGSCSPCRLVTVSFACASLTDEAESCPMSYRCMCNSKSYPIP
The following text describes a protein:
Function:
RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAALGGGADDDFDQFDKPGAERSWRRRAGDDEWDSELEDDLLGEDLLAGKKNQSDLSDEELNDDLLQSDNEEEQEFRSQGVTVSLNATSGMFTSYELSENISDPSVEHESGYNQGEDEIGYDKSEAPEVYASEYSEEGHYEGNDPELTEDQIEYGEEPGEDDEVLDLEINEPLDEFPDEDYMQSYNEQAMEEQEEYTADEELEESQTMTNESEEAAIESLELQEETKEESDEEEDDDEESGRLRFKTERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQLKQGRYGSRRGGRRGGSIMCHGMGEQRRDNDRGRMKDHRPALLPNTPSTMTHSQRLIPTHQQPVRSLFQHQQQQQQQQQQQQQQQQQQQQLQSLLPLQHQHHSSPPPGLHMPPQIETPRIMMTPPPVTPQQPKNIHINPHFKGTVVTPVQVPLLPVPAQPRPAVGPQRFPVPPDFQQHTPGPVPTSFSQAPRLPMQDQWRGPPPPPPPLPPPPPQDRDPFFLGDPRFPSHHLFEQRSPPPPPPPPLLNSPHPVPTQSPMPFSQPGPAFSQQGQQPVFPRERPLRPNIQPQGPVGILHFNQPGSANPRPFIPPRQQFLQAPGQPFLTAHAQPNMQGPLHPPLQPQPQPQPQQHHHQQQQHHHQQQQQQHHHHLQGPPQPLMPMNQPQFRPHMQASPQQPNNNRMQCQQRQGPMKPRHSTPSQNIVKRPNQQLQPTAPRNSNLRELPIAPSHALEVSNNRRASTPAAQVKPITSTMSATKTVAGGGNSQGRPEMKAKAVTPVGQAKPEVKSEPEYPDEDEETRLYRLKIEEQKRLREEILKQKELRRQQQAGARKRELLERLAQQQQQQQQPSMQQSYMQQDDDSSEYPTNGNPYIPHSGLQTRQNVKNRLLVKKQDVVVPNIQPKHTDYSQVGANTQYQGQQMKPVKQLRQTRTVSPSQPQASQKVLQTKPAAAPLPTTQTARVASVQARPQEMKPGVKRTVMQRTNSGSGDVPHVGSKVRVIKLSGGQGGEDAGFFHPEGQPQRPQQPLEPKQQPVRKVTLTKGMQQQQHQQQQALIRSAAPQGVKNIQGIHQPKKVIMHGRGRGVAGQMGRGRLMPNKQNLRVVECKPQPCVVSVEGLSSSTTDVQLKNLLMSVGPIQSLQMLPQQRKAIAKFKEPAHALAFQQKFHRHMIDLSHINVALIVE
The following text describes a protein:
Function:
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.
Sequence:
MSISVDSVEQFQEIVQSNKEKTIILNFYAPWAAPCQQMNQVFDQLATEAPNAVFLKLEAEKLPDVAEIFDVASVPLFVLIKEQQVISRISGANPQKLKEAVDEHVNKLPGAKAADASATKSTSTAASNTSAAPTAVKETAAVSAVESGEVRKEGEQESEQELNARLEKLTRAHDVMLFMKGIPSEPACGFSRKIVALLREQGVQYGYFNILADNSVRQGLKTFSDWPTFPQLYIRGEFVGGLDIVSEMIETGEFQQMINGSA
The following text describes a protein:
Function:
Mediates heterochromatin assembly by promoting RNAi-mediated heterochromatin silencing and histone deacetylation. Binds pericetromeric transcripts and recruits the RNA-induced transcriptional silencing (RITS) complex to heterochromatin. Recruits sir2 to chromatin to promote deacetylation of 'Lys-9' of histone H3. Involved in bipolar spindle assembly during mitosis. Required for proper localization of kinesin-14/Klp2 on the spindle microtubules.
Miscellaneous:
MISCELLANEOUS: Shown to localize to the nucleolus in PMID:16823372 by overexpression of a C-terminally tagged allele, however this allele was subsequently shown to be non-functional in PMID:33693625.
Subcellular Localization:
Chromosome. Nucleus. Cytoplasm. Cytoplasmic granule. Note=Dri1 is dynamically shuttled between the nucleus and the cytoplasm and exported from the nucleus through the Rae1-dependent mRNA export pathway. Localizes to the cytoplasm throughout the cell cycle. Upon mild heat stress, a portion of DRI1 assembles into protein aggregate centers (PACs), sequestering it into the cytoplasmic aggregates and limiting cell division at high temperatures.
Domain:
The RNA-binding domains (RRM domain and RanBP2-type zinc finger domains) are essential for DRI1 cytoplasmic localization and function.
Sequence:
MPLPESVGDLVVLHFETNLDDHGISIGRAPCEIHEICWVILDGKTLEKQHCESCSIREDSSRHGICGSASSLTEAIFTLDNSIQERLNFQGKPFTFVVMNGRELRVLLPKEARDQGITLPSYMRHPRLFDLSSEYAKWQIRMGAVPPYTITLSHIFGKLDVDSLPPITESKAIELSPSDAPYITKGLTQCWRLANATTLLLRKAEKDSRGHSLPSVLTQPINCQADARSFYAERSKIVHVAGLTNDVTQLELESWFTNHGVHPVALWTLKTPEPYKSTGTGFVLFASHEDAADALAFNGYCLGDRMLEIIPSSTKVLDKASDILIPFPSSKNRPRPGDWNCPMCGFSNFQRRTSCFRCSFPGPTHVSAATGSNTFSPDFPYGNSYGNGSSHFIANYGGSVHHSNENTMQSDLQHQNGNNAVNHHHSSRSFGGNVPFRAGDWKCGSEGCGYHNFAKNVCCLRCGASRATAAVVADHASGPVNGSYSHNSYSHIPPVMSTSPPNHSVYPYSQLSINSVTANHGQNFGGQNGGNVSRFDDHGRFKEVSRPSVTTDQGDWLCECGFTNFRRRSNCLRCNAPHYSNMQIPASLPSDFNAYV
The following text describes a protein:
Function:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
Sequence:
MEIVRSHRQVAAAAAGGGAGALPTYKAAPQLEVRLEEFELFAIDRLRVLKGISDGLSRGKRPEEVEKLVNELWKTHMGHQDPAETLNKDIISHFVLRLVYCRTEELRKWFLSMETTLFRYRFRLENPESQRMLMTEFQLPYKALPHSEFEAVKDKLSQVARSIGQSANVDHVFFKVWTLVLAIYPFSIYIFCSVQKLIPSKSYCNPIKVPFEQVPDLVASRRVFLSKGYAYVAMNQVVSLVVTQFRCNISKALALTNRKWSATIKEQEKDRLTPIVEALSNAYFGPDYSQPKDAVDISLKDIDQLAKSSFPLCMRHMLDKLRENHHLKHGGRLQFGLFLKGAGLKLEDALAFWRAEFSQKIGSERFDKEYAYSIRHNYGKEGKRTDYTPYSCQNIISATPGVGDHHGCPFRHFGEENLRAALNKMGVGGHALEEIIDKVKNRHYQLACTLTFETTHGVSCDSGINHPNQYFSESQKVLRAKNQKMESQSAT
The following text describes a protein:
Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Subcellular Localization:
Membrane.
Sequence:
MAAEPGLLLGAVLCILPLLPFGTGALLTGLTYPEPPFNVTVDMLPDRYSVMWDWNSVNWGDTKNVTFSVLLRKLKKKTQWNSVPGCLHIPHRNCSIDPALVDIDKRYQVRVRAEIAQINFSFSDTITFTPKAPGEIALPIAVYVESIDGGVKIKITLPNTREYWDNALFDYILLLRTNSSIEERRSLYPNFYLYDLNPGENYCFKVKVSSYLTKTNDTFSPEKCFKVEAVGLDGRPYPENVTMEALNTNYMLKWDWDYSQHPNVTFSVENNSEIWPGKWNQVQGCENISRRNCDVSGIYIYGKYNFRVAASLDNNNRTLSRALRFNPEKDTVIGPPSNVSTELYGTKLHVNVLKVEAFHNDDLKNYCDWEYNLIYWKDSASDREEKTLNEKVGRFTIEVEASTTYCLTVRVVCQTHNRSGLFSETQCITTGADALPVWSAGIVIGVLLSVVLTAVLVYLCACPLKRYVKHIFYPTGKLPSSIESGMFDSRVKIPFVLQEEEPTDLCYIIRNSEHDEDSVQNRKYSLKESNTDSGNYSNEDETTGDNGLSIQRM
The following text describes a protein:
Function:
Necessary for the efficient intracellular multiplication of tobamoviruses, being a component of the replication complex.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MACRGCLECLLKLLNFLLAVAGLGMIGYGIYLFVEYKRVTDNSVTFDLTNGDQSYVSFGRPILMAVSLSSNIFDNLPKAWFIYLFIGIGVALFVISCCGCVGTCSRSVCCLSCYSLLLILLILVELGFAAFIFFDNSWRDELPSDRTGNFDTIYNFLRENWKIVRWVALGAVVFEALLFLLALMVRAANTPAEYDSDDEYLAPRQQIRQPFINRQAAPVTGVPVAPTLDQRPSRSDPWSARMREKYGLDTSEFTYNPSESHRFQQMPAQPNEEKGRCTIM
The following text describes a protein:
Function:
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MTFLKLKDKQVGSVLAASYLGYTSIFWFYPFIWLAVLSLTEWRFVGIPTFNGLNNFILVMQDPLFWKSMLNVMRFLMYYLPIVFISSFLFAFGLQKLKHGRTFVALSFLLANVSSGVAYSIVFSKIFSQNGPLNTFLYDWFGFTLPWLTSPDFAMLSIALVVTWKFVGYYGLILFSGLNSIPKEIYSAAELDNTRTIKRLFHITLPMINPQLIMVLVLAITVSFAIFTEPYLITGGGPLNSTTTPMIVMYETAFMKMQPSWAATMSIFIALISFGIILGVRKLLERKVEIV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase that catalyzes the transcription of viral genes.
Sequence:
MDLIQQQIAHEEALVGAAQNDARIALEKAIAQGSIDRIPRARIMLMRMLPIVTEAIFAHQEAKAAGPAAKLRHLLRIIDAQDLAVMALRAGLSMLINYPTITATKYYTHMGKMLCREIEVRLAFKVNQPYYDRTLDYLKTSRTRSVRHIQKTMDALLDAVLPEEARIDLPDGDYLRLGKFIGDPLIQCGLFEPNRFTGRGGTSVHLEPSPEAREFLQDPSAAMTWGGPGRSVMLAPPRPWNDWCDGGYYSAKAQKHHVLVRRTKHQTKRARQAQLRHLGQDKMPKVYEAVNVLQSVAYEINRDVYEIIERVFNSGGGVLGIPQRTYPDKPEFPLGDEWAKENASEQELEAFNRWKRSVHRWYTGEREHTAKLREFAALYRVVREHHGKAVYFPMHVDSRGRMYYWGTPNPQGSDIAKACLRFHDKRVLGKRGLYWLKVHVANSLGCDKVYFDDRAAWVDERWDDFQRALAEGPENYPGLFPEAESPLCAIAGLLELRAAYASGNPEGYRSGFIVHMDATCSGLQHYSAILRDEIGGAYVNLLPPGLAKADIYSRVLGLVNESLERDRAPGAEGEARGYALLWDKAGLSRSLTKKPCMTLVYGTTFKGVVDHCLDYLDESGVEIPEGVPSYRLGSYMATLILDAIRETVPSAVFAMEWLQRLAKALPDASKDLHWITPLGMQVFQSYPKTEEVRVRLRAEAVEYVTLYEAKDELDPMRNANGIAPNFVHGLDSSHLGLTALACAAEDIPIQAIHDSMGTYASDVDRMHVHIREQFIAMYSGPCVLVELAKQLGVEATPPRRGSLNLEAVRDSWAFFC
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MISWSSLYHVVEAMMPLYAAMALGYASVRKKAFTPEQCAGINHFVALLAVPLLIFRMISSNNPYTMNIRFLAADTLQKVIILAALAAWARFSNNGSIAWVITLFSLATLPNTVLMGVPVLRGMYGPMSENLMVQIVVLQFVVWYVLVVFLFEYMAAQNAFMEQQQMPPPQANGSHSVDIPAVNADGSDPDVSIAQEETIRPSGMLILVMAVKKILKIPSTYASLLGLFWSLIAFRFGIKMPAIIDNSLSIISVSAIGLGMFSVGAFMAQRKKFITCGYYLAVLAMVMRFLIGPIVMLVSSFAVGLQGVFLNVGVVQAALPLAVLSFVYAEEYNVHPDIMSTGVIVGIFISVPLTILYYVLLGLER
The following text describes a protein:
Function:
Required for the polymorphic O-glycosylation of the serine-rich repeat protein PsrP. A stabilizing protein that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins encoded upstream in the same operon. The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to PsrP, attaching the first sugar residue. Stabilizes the glycosylation activity of GtfA (By similarity). Has no N-acetylglucosaminyl transferase activity on its own.
Miscellaneous:
MISCELLANEOUS: Encoded in RD10, a pathogenicity island with an atypical GC content that is associated with invasive pneumococcal disease. Pathogenicity islands account for greater than half the genomic diversity observed between isolates. The main function of this island seems to be correct synthesis and export of pneumococcal serine-rich repeat protein PsrP (Probable).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
The N-terminus of the protein, including the glycosyltransferase 1 domain (residues 1-171), is required but not sufficient for full formation of the stable GtfA-GtfB complex; the complex of GtfA with truncated GtfB has intermediate N-acetylglucosaminyl transferase activity.
Sequence:
MIELYDSYSQESRDLHESLGATGLSQLGVVIDADGFLPDGLLSPFTYYLGYEDGKPLYFNQVPVSDFWEILGDNQSACIEDVTQERAVIHYADGMQARLVKQVDWKDLEGRVRQVDHYNRFGACFATTTYSADSEPIMTVYQDVNGQQVLLENHVTGDILLTLPGQSMRYFANKVEFITFFLQDLEIDTSQLIFNTLATPFLVSFHHPDKSGSDVLVWQEPLYDAIPGNMQLILESDNVRTKKIIIPNKATYERALELTDEKYHDQFVHLGYHYQFKRDNFLRRDALILTNSDQIEQVEAIAGALPDVTFRIAAVTEMSSKLLDMLCYPNVALYQNASPQKIQELYQLSDIYLDINHSNELLQAVRQAFEHNLLILGFNQTVHNRLYIAPDHLFESSEVAALVETIKLALSDVDQMRQALGKQGQHANYVDLVRYQETMQTVLGG
The following text describes a protein:
Function:
May be involved in localization of sqd to the oocyte during oogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MVSKNQFYQNWTMQSQQQHPHQMQQQFQQQQQPNLQHRNNQSNNNNCNNNPRAAAAPYRKPFRSGKINSGPGGNGNGNRVNGNNQMMFSSSQMPSDPLYIDFSSPPPGFKHNQVGSPKKKSMKGIKQQQHPSPNQQQPPSPNQQQHPSPNQQQHPSPNQQQHPNSNQQQHLSPNQQQGKMNNQNNNHMNQSQQPFNNQMNGSDWQRHPGNNPNQIRGGFNGFQRGPPPNRPPPRLMMGPPMGPMGPGPRGPGPMGPGGPYPQMPFPPPVPGMRGPGPMGPMGGPPPPPPPLFMRRNGPGPGPMMGVPPPMHMMGPRMPPRGIPPVGPYGPMNMNGGRIMKPNPKLIKQVVKGKSSIKTLKNLINQYPIEKPWVTDEIRSEHDKKVDIENRLKGHKDDELFAQYKGQRDKFVSLYEAAREEYLKQEAATVKAKDAKSDKDKNAISSQSAAPKAGSAKDATIPNP
The following text describes a protein:
Function:
Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGGIFSPLEGLGALDGPRCHPLVCFLCHEQYEQPCLLDCYHNFCASCLRGRANDGRLACPLCGHQSVVKGNNGLPPVDRLLQFLVDSSSDNEEAVRCANCDQECHKQDAETTYFCNTCGQPLCARCRDETHKAKMFACHDIVALSKRTMDIHKKCSLHSEPYIMFSTDKKSMVCIRCFRDMHGESRAHCIDIETAYLQGCEKLDQAVLAVKSLQVATLEAIALLQAMLEEVRRSAAEEEGDIHALFSSMQEKLAERKTLLLKAVQSQHEEKEKAFKDQLSHLASLLPTLQVHLVTCSAFLSSANKAEFLDLGYELMERLQGIVTRPHRLRPAQSSKITSDHRAEFARCLEPLLLLSPRRVAGSGGNATLLSGGPGAKTLVRPGCLSSCGKMSGSPVRKPTLHRYISTKVLLAEGGDTPFTEHCRNYENAYRSLQSEIQNLKDQVQELHRDLTKHHSLIKAEIMSDILQKSLQVDKQIASEYSSVEMMRSIFEETWEETYQRVANEQEIYEAQLHDLLQLKQENSYLTTITKQITPYVRSIAKVKERLEPRFQEPTDEQPETLPKIYDDSLIVSETQPRNDPLRSPGDREKVLESREDGQTLNTFPEETFLKNKDYYKHKPKSGVTGPIQKEFTS
The following text describes a protein:
Function:
Phosphorylates eIF2-alpha, from 1 to 7 hours after the onset of development or during the preaggregation state, resulting in a shift from polysomes to free ribosomes for bulk mRNA.
Sequence:
MAPGEIIIFELCQAVQEFLLLYNKETVSLHEEMIKRLNTNINRVNSSDDINNNNNNNNDDDDDNDDYDDSDDENSDSDYDDYDDSDDENSDDEFYSDDEDYNTRHQMGDIGSSVNKIINSIDHTISHGGGVGVGIGSGNGLFSKSSSSSSPMIPYNFSFDSLNGFDPDIIFEDSFQTPLKGSSSIDFEEMNNLTNSNNSNSTATTTTTTTTNNNNNNNTNNNNNNNSNNNNNNNNNNNNTNNNTNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNISNNKINKINNNNNNKELIDNNNNNKDKENDLINDTIPKIKWKKGSCIERKSNYSVYRGVDEDTDRKLICKIVNLNIDDRSSSSLTSLSNSNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNLSIDVVELKKRLIEKVKMIQKEIESMKYLGNPYIIKYLGTNFQEGQNTLYIFQEYNSTLTLQQKILSNGIGFEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSHNIFFNQSTSKMLLSNYGGRNIKIFDHFEKLNSLKNLNSWISSTNNSINNINNINNNNNNNNNNINTTTTQNQINNEIDRREDIINLGIVVLEMLCGSDLANNQTVLIYLAQLNLLNNQQQNQNFIQPPPLQYQLQQQYDLIKEIEQKTHPSSPISNNAKDFLSLCFTINGNGSTNDSLEAGILLKHPFLASNSNSTPPPSNFLNFTNNIKFLDQRSAATQALLSSPHSLIPQPIQTLIKSQTPNNNNDNNNLASSNELLSSSNGSNIDLRSTNSSIVSNPLATSSSLDNITPPPSRPISPKPSPLNKRNQKLQTSQQKPPLSPPQTPLKQIPQSPQSPPQQNFNTPPTTTTTTTTPTATPTTPTMTPLTPIQKQQQIDYDMFRYHSRYRTDFEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNTANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLLPSKMEDDILKEAIKTIANPTISLFSYLMEKLFCLSNDEHIMSRYLYTSNPSLTPMHLICREKTFSRLEKIFLNHGSIRIDTPTLFPKNPTNSTHPGAANVAKFLDESGTVVYLPYDLTIPWARHVVIHNIQQAKRYTFSKVYRRSQPGFSPKELYECDFDIIGPSKSRHISDAETLRIIIEIMEEFKDELFGNNSGSNSGSGSGGSINYKIRINHYGLLDSILSECGVEKRFFTVVYQTVAQLHWRLNWAQVAQSLKEHGLSASIVSNISTYFRQRGELAQCVTQLESLLANHKEATTGISDLKILVRNLQMINIIPRFLLDLSLIHNHQYYEGLVFQAYIERPTLSNPSRTEIIMSGGRYDKLIKSLHPNPSLSNNIVSGVGVTLACEKIVNSVLNYRQHLLNNCFNTTYTRRNKDPPNSNNNPNNNNLNNNVSIFTKFQSHIEVFVCSLGSSLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENGIPWVVILREKAFQIGKLKVKQIETRQERTVARKDLVDFFLKSRKHNVDSKNIIQNTSSSDLSNLIGGINNSGSGGSGGSGGGSSMSSGGGGGGNSNIGGSDHHHHGHHSNQSTSSSGNSNNSNTQQTSPIQHHVHFSNTKSIIGSSGIISNATFSGGSSSSSNIIHFDEPTDSFSTQIVYQGVEEIKKSKIETLVQTSLSKLFRGFIQSKSSTIRVIVTDLAYSVIRDLQISESHDNISKFQRVSKEKLLQLKNQIFKWKVYPFIVIHSIKDDKSVIFNSVV
The following text describes a protein:
Function:
Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to dihydroxamate rhodotorulic acid. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLVHIISFLLFFQLSAAKAPPSKTSLINTHERRSIYSCYVGLRKETWGFNGSAICRYEPAIQSMLYCLYEDTHEKGYSNKTLEKGFEEMRQFCYTPKFLNMTDAEFYTSLDNGTYYIQDQPKAGINITYPIRLNTTLRKAYYDAYYGYYYNHDIPYYFGGIICAYFVGVMLLAGLIRFLNYTPIKKIMFQQKLVNYVRGYTTLPTLYEKHAEPFSYLKVITGYLPTRFETLVILGYLILHTIFMAYKYQYDPYHIIFAAHRAEVAHFVAYRSGILSFAHLPLIVLFAGRNNFLQLISGLKHTSFIVFHKWLGRMMFLDAIIHAAGFTNYYLYYKKWNTVRLRVYWKFGIATTCLAGMLIFFSIAAFRRHYYETFMALHIVFAALFLYTCWEHVTNFSGIEWIYAAIAIWGVDRIVRITRIALLGFPKADLQLVGSDLVRVTVKKPKKFWKAKPGQYVFVSFLRPLCFWQSHPFTVMDSCVNDRELVIVLKAKKGVTKLVRNFVERKGGKASMRLAIEGPYGSKSTAHRFDNVLLLAGGSGLPGPISHALELGKTTAASGKNFVQLVIAVRGLDMLNACKKELMALKGLNVQVHIYNSKQELASAEKISSNEVKNGETTAEKAPSSLSNSEKAPSESENTELPLSLNDTSISDLEFATFHVGRPNVEEILNESVNHSGSLAVVCCGPPIFVDTARNQTAKAVIRNPSRMIEYLEEYQAW
The following text describes a protein:
Function:
Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Co-localizes with MGAT1 and IFITM3 at the perinuclear region.
Sequence:
MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPTAPPPPPYPYLVTGIPTSHPRVYNIHSRAVTRYPANSIVVVGGCPVCRVGVLEYCFTCLGIFLAIVLFPFGFLCCFALRKRRCPNCGAVFT
The following text describes a protein:
Function:
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSLVKEYINKKVEVVTTLGKVYIGILTGYDNFMNIVLKNSIERTFSKEGVSNISCGLLILRGDEIMVIGGLNEEKDTQLDWQCVVSNPLSQALI