lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MSARLRVEELRAALLSRGLDVSGTKNALVRRLDAAICKDEKIAVAAAATEVADGYGVAVDGVLVDGKGNGRNNKRKRSGDGDEEGNGDTSIDLAKLEGMSYRELQGLAKARGLAANGGKKDVIQRLLSATVDPVAVADGGPQGEKEVIKGGDEEAEVKKEKIVTATKKGAAVLDQHIPDHIKVNYHVLQVGDEIYDATLNQTNVGDNNNKFYILQVLESDAGGSFMVYNRWGRVGARGQDKLHGPFLTRDQAIYEFEGKFHDKTNNHWSDRKNFKCYAKKYTWLEMDYGETNKEIEKGSITDQIKETKLETRIAQFISLICNISMMKQQMVEIGYNADKLPLGKLSKSTILQGYDVLKRISNVISKADRRQLEQLTGEFYTVIPHDFGFRKMREFIIDTPQKLKAKLEMVEALGEIEIATKLLEDDSSDQDDPLYARYKQLHCDLAPLEADSDEYSMIKTYLRNTHGKTHSGYTVDIVQIFNVSRHGETERFQKFASTRNRMLLWHGSRLSNWTGILSQGLRIAPPEAPVSGYMFGKGVYFADMFSKSANYCCASEACRSGVLLLCEVALGDMNELLNADYDANNLPKGKLSTKGVGQTAPDMVESKITDDGVVVPLGKPKQEPSKRGGLRYNEYIVYNVDQIRMRYVLLVNFNFKRR
The following text describes a protein:
Function:
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m-xylene and p-xylene.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVAIDRTKGDQSTPGNIIRGEGYALIRNSEATPDPDKVIHIPCADSFSVIVQLRDFNSHRLWNGNKLVFDGGHPRKSISIAYLGDEIKCQHRTTYDNVRFMLPRASIKEFLYEEGQRASAEPERIIGVDDPVVYHLALALLPSFARAGERNELFIEQVMLALLTHVQDRFASTQVPVCTGKGLAPWQLRRAKELIAGHLAEGVSVARLAEECGLSRSYFTKAFKCSTGVSPHEWLMRMRVDRAKELMLGSDEPLSQIGVACGFSDQPHFSRIFLRLAGASPSTWRRVKRQRTDAAL
The following text describes a protein:
Function:
May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions. Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cell junction, tight junction. Nucleus.
Sequence:
MPAFPTLDLDGKLGKMDRVVLGWTAVFWLTAMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSPRAQALSKRNLEWDPYLDCLDSRRTVRVVASKQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVILGIFLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHDDDSNFRQSYHQMRNKQFPMSGDLESNPDYWSGVMGGNSGTNRGPALEYNKEDRESFRHSQQRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRSRRANGNSHEARAGSRFERSESRAHGAFYQDGSLDEYYGRGRSREPPGDGERGWTYSPAPARRRPPEDAPLPRLVSRTPGTAPKYDHSYLSSVLERQARPESSSRGGSLETPSKLGAQLGPRSASYYAWSPPTTYKAGASEGEDEDDAADEDALPPYSELELSRGELSRGPSYRGRDLSFHSNSEKRRKKEPAKKPGDFPTRMSLVV
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGRCEFYHPFTPYRIQLELMQQIYGLLESGKKMGIFESPTGTGKTLSLICSTFTWLREHKAGYLQGSTGAQDSEEDSEDEPAWVKENYEQSVLADVTASMRAYEQRLAAVDTDLLVKGAAKRQRVEVAVERPDDGAEFLPDAYHSDVEERPSHAGGRGQLRKQLDADIKRLLRKLDEPDAADKSRLAANPLKVYFASRTHTQLGQFAAQLRLPQFPPSLAGLEQERVKFLPLGSRKQLCIHKKVSKVKSDGINEACMDAVSKSECSFFSAAREPDIIRQFQDQAFSTIQDIEDLVGIGNTLHACPYYSSRELIEGAEVITLPYQHLLLENARKTMGIDLRDSIIVIDEAHNLIDTINSIHSASISLTELRQCKLALQAYLAKFKTRLNSGNRVNLLKLIKMVDVLSQFIETQYKNGKRINDPNDIFMGTSMDVVNIHKLEKYMKTSKVAYKIDKYIQATTSNDLQDRGSRDIKQPILFKVASFLKTLANPSEEGQFFFENGHVLKYMLLEPSEVLKSIVTEAKCVILAGGTMEPVNDFFTQLVPYLAPTDVTTYSCGHVIPDDNLNAFIVSENFEFTFANREDIALIERLFHFIYQLASRVPFGMVVFFSSYKYIDFVVKTWTDRGLLSRLDAIKRIYHETSDGADVLKGYSETIQSEKKGAILLAVVGGRLSEGINFENELARAVVLVGLPFPNMFSGEMIVKQQHIKEKVIRNGGTQEDVNKAVREFYENICMKAVNQSVGRAIRHASDFANVYLIDKRYSGPRIQQKLSDWVRKRIQSASNIPKILSDTEAFFSGKGL
The following text describes a protein:
Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Sequence:
MVAIRFCRIAIFLCAFAPNRFPTHRPAMAADISKIRNIGIIAHIDAGKTTVTERMLYLSGAKHRVGRVDHGTTDTDDDPEEQERGITIFSACVKYAWGDYNVNLLDTPGHVDFTAEVERCLRVLDGAVVVFSAREGVEAQSETVWRQADRYEVPRIVFINKMDREGASFETVFNDIGPRLGGRPVAVELPVGEGPAHVDNPFRGVIDLVDMKLLQFDPETEGKQVTETDLPDELADDAAIWREQMLEAVYEISEDAMSLAMEDKEVPRDVILAALRKGCLDRTIQPVFCGSALHGIGVQPLMTGVGNFLPSPLDRPAVEGHDPKKPDKTLSRNPDPKEPFCGLVFKILPAKTGDNYWIRIYSGELKQNSRVQCPNRDKKENVAQIWQIHATKKDRDGQVDSVGAGDICCVIGPRFAITGDTVCDTKELIELPSIKFAETVLSMAIEPESTADRKKLEETLDMLRRQDPTFRAVDNEEIGQTIISGMGELHLEVIQHRLTRDFGLNVKFYKPRVNYRETIGGSAELVGQCNRVVGSTQMFARLKVKISPTDNPSDPVIVFDRLPPDVGLPNAVRSAAIDEIRDRAEGGGMIAGFPLSGVRIDVMDAEMAEEGSDEVAFRIAAGDAFESGLQAAGPVLLEPVMRVEVTTPEDYMGEIVGDLQQRRAIIASTESRGAMTVITAHAPLKEMFGYSGAVRSLSQGRAGSSMEPYGYQAAPKEDADSFQY
The following text describes a protein:
Function:
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MGKALDREASLLGPVFPEAPVSAHGKAPPRRRLSLCTCGMGTRAQLGGPGRRPTCSRSSPRRLFPQSEGASPCASLSGGPPSPWRRTRWRAAATRPRGLAGPRSPLRAAWAWAPLKRCRQTAATPRPLRGRRRPTTPAWGKALTEAAALWKKYLRAARAQTLCPTDLGSAIDKIIESTIGPDLIPSCITVTSAEDGGAETARYLILQGPDDGAPMASPMSSSTLAHSLAAIEALADGPTSTCLEPPEEARGRPSSPAQPPPGSGTEEPDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPAAAAAAGKKGRLRKWGTSAKTQEEEGPEEEDDDDIIDAGAIDDLEEDSDYNPAEDEPRGRQLRPQRPTPSTPRPRRRPGRPRKLPRLETSDLPDGVEGEPLVSSQSGQSPPEPPDPEAPSSSGPGCLAALGKADRAPVDPGVSQSDAENAAPSCPDEPDALPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVVRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPPSSPAPPEIPPEAAPFQAPETPPLLCPDTLGGATIIYQQGAEESTAMATQTALDLLLNMSAQRELGGTALQVAVVKSEDMEAELACPGGQPSPAGATPQVVTLHVAEPGSSVAAESQLGAPDLQQITLAPGPFGGTGYSVITAPPMEEGTSAPGTPYSEEPPGEAAQAVVVSDTLKEAGTHYIMAADGTQLHHIELTADGSISFPNADSLASGAKWPLLQCGGLPRDGPEPPSPARTHRVGDSQGSASPPPVANKALGLGVPPSPPSAATASSKKFSCKICAEAFPGRAEMESHKRAHAGPSAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKKDLRRHMLTHTNEKPFACHLCGQRFNRNGHLKFHIQRLHSPDGRKPGTPTARTPARTPTQTIILNSDDETLATLHTALQSSHGVLGSERLQQALGQEHIIVAQEQTVANQEEATYIQEITTADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPEGHHIQVQEGQITHIQYEQGAPFLQESQIQYVPVSPGQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEHIQQLQHQGIEYDVITLTDD
The following text describes a protein:
Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MKALRRFTVRAHLPERLAALDQLSTNLRWSWDKPTQDLFAAIDPALWEQCGHDPVALLGAVNPARLDELALDAEFLGALDELAADLNDYLSRPLWYQEQQDAGVAAQALPTGIAYFSLEFGVAEVLPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRSGYFRQSLTADGWQHETYPSLDPQGLPLRLLTDANGDPVLVEVALGDNAVLRARIWVAQVGRVPLLLLDSDIPENEHDLRNVTDRLYGGDQEHRIKQEILAGIGGVRAIRAYTAVEKLTPPEVFHMNEGHAGFLGIERIRELVTDAGLDFDTALTVVRSSTVFTTHTPVPAGIDRFPLEMVQRYVNDQRGDGRSRLLPGLPADRIVALGAEDDPAKFNMAHMGLRLAQRANGVSLLHGRVSRAMFNELWAGFDPDEVPIGSVTNGVHAPTWAAPQWLQLGRELAGSDSLREPVVWQRLHQVDPAHLWWIRSQLRSMLVEDVRARLRQSWLERGATDAELGWIATAFDPNVLTVGFARRVPTYKRLTLMLRDPDRLEQLLLDEQRPIQLIVAGKSHPADDGGKALIQQVVRFADRPQVRHRIAFLPNYDMSMARLLYWGCDVWLNNPLRPLEACGTSGMKSALNGGLNLSIRDGWWDEWYDGENGWEIPSADGVADENRRDDLEAGALYDLLAQAVAPKFYERDERGVPQRWVEMVRHTLQTLGPKVLASRMVRDYVEHYYAPAAQSFRRTAGAQFDAARELADYRRRAEEAWPKIEIADVDSTGLPDTPLLGSQLTLTATVRLAGLRPNDVTVQGVLGRVDAGDVLMDPVTVEMAHTGTGDGGYEIFSTTTPLPLAGPVGYTVRVLPRHPMLAASNELGLVTLA
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEPRAVLKQGNRNRDKDSVGLGNRLRFVSISSALNPMTFSSILRHLQTLPLSKDLREKLQKRGHVQLSGLPRLPKGLIVSSLAQSLEKNLLVITATLEEAGRWTAQLELMGWQTVNFYPTSEASPYDPGRLESEMVWGQMQVLAELIQGHQVKGKAIVATEKALQPHLPPVATLREYCLALRRGQEMDSKSLELTLARLGYERGSTVETEGQWSRRGDIVDIFPVSAELPVRLEWFGDELEKIREFDPASQRSLDDLTGLVLTPTSFDQVIEPALNAQAIDLSAWGEDAETEQLFGKEGLQRFLGLAFTEPACLLDYLPTETVCVLDEPEQCAAHSERWFEAVAQDWSALQLPNLPQLHRNFSALGDRLKTDFQYITLSEIHEANGDSLDISARPIPTMPHQFAKLAEILRGKREIYSGLTLGQYSTWLISAQPSRTVSLLQEHDCAVQFIANPRDYPAIEKSQIQRTAVTLKYSGLAELEGFILPTFRLVLVTDRELFGQHALATPEYVRKRRRATSKQVDINKLSPGDYVVHKSHGIGKFLKLDALANREYLMIQYADGILRVPADSLDSLSRFRHTGTRPPELHKMGGKVWEATKNKVRKAVKKLAVDLLNLYAKRAKQVGYAYPPDSPWQQELEDSFPYQPTPDQLKAVQDVKRDLEGDRPMDRLVCGDVGFGKTEVAVRAIFKAVTSGNKQVALLAPTTVLTQQHYHTLKERFAPYPITIGLLNRFRTASEKKEILAKLKSGELDIVVGTQQVLGTSVKFKDLGLLVIDEEQRFGVNQKEKIKTLKTEVDVLTLTATPIPRTLYMSLSGIREMSLITTPPPSRRPIKTHLSPYNPEVIRTAIRNELDRGGQVFYVVPRIEGIEELGGQLRQMVPSARIAIGHGQMEESELESTMLAFNDGEADILVCTTIIEAGLDIPRVNTIIVEDAQKFGLAQLYQLRGRVGRSGIQAHAWLLYPNQKQLTEKARLRLRALQEFSQLGSGYQLATRDMEIRGVGNLLGAEQSGQMEAIGYEFYMEMLQDAIKEIQGQEIPKVEDTQIDLPLTAFIPSDYIPDLEEKMAAYRRITSIESTDELPKIALDWGDRYGMLPSPVEELFKVVKLKHLAKSLGFSRIKVEGKQNLVLETPMEEPAWKLLAENLPNHLQSRFVYSAKKVVVRGLGVLAPAKQMDNLIDWFGKMQGALPETKMETLVGK
The following text describes a protein:
Function:
Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.
Subcellular Localization:
Chromosome, telomere.
Domain:
The C-terminal wHLH region seems to mediate telomere-specific function.
Sequence:
MDKYGHIAHQEGDVCYYIPRLFKYNSYYSGTEDVRIFVGDLKYRMRVSLQICEKYYDRRLSMLFWKNHPLQQIHLIGCIIGLQFKWIGKQEYIFFQLDDCTSDSSLVGYTSDMRFLTCKVKKDSILSWGLNITDLIGLTLHVYGQASLNYQELQVEYLRLCYSLTEEIDHWKITMNMREQLDTPWSLSDFVIGELFTQEQEWTPETSQIEVVNPDFVGIGYKTPESKRNETTFIEQLQEERLKDELEIISPYNSTDTSNSVHSLSFRFVSSLKDFPETHFLNSGDQIDNGNDEQLKKLEYQSANLPVMIPNRTSAKSNLMLILLGLQMKEISNSDLYKLKEVRSVVTSLASFLFQQQNVGVMKSFDSLEKEAFRDLVNRLVSQGLIGLKDKTSETFDLLPLKNLFEYAEKRISVLMKLQCYTGTVQLSHVQEKLHLPYITTNGIVDVFKECLKRTKKQYPEVLKNWWIDLDPKNGMEDQNSGILLHLEYAAAYS
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg1.
Subcellular Localization:
Nucleus.
Sequence:
MFVPIGSEQDFPSDYTLLLPAISVGNVGQLAIDLIISTLKIPKVGYFYTDCLVPMVGSNPYETDEENAKELCTNAEVYALPSQKLAVLQLRSLVIKKKSKSFRQALVSWIKRCAFARVILLSSCHAYHRDDTQLFGTPFRYLVTPALQKSVADVLKELEWKEMEKVSSYPGLNDNEKRVFIPGGGFTKRFYDDCCLEDLQMAVVLKFCSEGDNVPDAFSLLNQVNEWLHLVASTNGDVLAKWKAPGSWQLLFGSGLPAAIF
The following text describes a protein:
Function:
Responsible for physiological and behavioral changes in mated female flies.
Subcellular Localization:
Secreted.
Sequence:
MKLIKVTLVFSLLALVFVAQTEAQNPIWENWLACNRIGTKALASLLRETIPTVRNLLNCIDFNPPTDIGNSYLSKLKLYYELVKRGALDKTQCLIVPLKESVRLLRPYVKSLETNKCLGE
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNDTKILIEKIKEGIQEKKGKNIIIADLTSIEDTICKYFVICQGNSPSQVNAIVDSVKEFARKGADSKPTAIDGLRNAEWVAMDYSDVLVHVFLPEVRSFYNLEHLWADAKLTQIPDLD
The following text describes a protein:
Function:
Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
Sequence:
MELKKDINAVSIDMLLIVHSEKRRAAQGTLSDQQANPSSLLQRGGGFQGVGNGVRRWQKLEGNDFHENLVEKQHPQQPQVITSYNSQGTQLTVEVHPRDAMPQLLKKFSLAKRLQGDKNGNTRPRQPGGKDAHAYPWDRSSLKSMSLDLQQFEKLDIYASQVTAKSGLDELVSDLLQEAHTDLERVRAIWIWICHHIEYDIAAAQEKDRQAFKPTDILRTQKTNCDGYAGLFERMCRLAGVQCMTVPGYSKGFGYQTGQSFSGEFDHAWNAVYLEGRWHLVDSTWGSGLVDTITSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFENNMYHKSEFYNKGMLSAHPETSMIRTVNGKATVTIESCAPTLFMFMLNGKQEHGLLSLRKNGMKLEVYPPTMGTHKLQIFAKGNSDIYSSVLEYTLKCNYVDMGVQLPAELHQPVGPSWFSEQMGIMKPSHPDPIIHTSDGRCSISFSVEEGINVLASLHGDDGPITEETQRRYIFQLHREKQTELKVQLPHAGKFALKIFVKKRQEPGNYIFVFNYLVCCANTKVNWPMFPESFGNWGQDNELLEPLSGVLPANRNVPFKLKLHGIAKVLVKGQDTWPLTLNHEGYWEGSCSTAGCQEVYVMVLENANHNFYSYILKYKVNAQ
The following text describes a protein:
Function:
High-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAAQDEREPLITPALPANRSGYGTVEDARDAMSKFVVNNVAGESGRKLPQYIAGLAASGGALAAGTFLGWTAPTDKPLTVEGEYGFPVSDEQFSWVGSISNLGAALMCFPIGYMMKLIGRKWSMLAMVLPLVLGWLLIIFAENVAMLMVGRFFLGVGGGAFCVAAPTYTAEIAQPSIRGTLGTFFQLMVTVGILFVYAVGAGVDVQVLSIICGVIPLVFGAIFFFMPESPYYFVEKGRYSEAASSLKWLRGAQYDENAEIEDLKQADEKVKAEAIPMLVAFRQKATVRALAISLGLMFFQQLSGINAVIFYNSAIFASANGGKEMSSASIIVGGIQVVATLLASVVVDKVGRRILLLVSDLMMAVSTILLAVYFQLKQDDPAKVDDLSWLAVLAVCLFIAMFSIGYGPVPWLMVGELFANNVKAFASPVAGVFNWLLAFLVTKVFTNLKDAMGEAGVFWLFSGISLLGTVFVFLVVPETKGKSLNNIQRLLAGEKLNADEPAGLPEPRDERDERPAQVA
The following text describes a protein:
Function:
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MRLNKMINNPLLTVKNLNKFFNEQQVLHDISFSLQRGEILFLLGSSGCGKTTLLRAIAGFEQPSNGEIWLKERLIFGENFNLPTQQRHLGYVVQEGVLFPHLNVYRNIAYGLGNGKGKNSEEKTRIEQIMQLTGIFELADRFPHQLSGGQQQRVALARALAPNPELILLDEPFSALDEHLRQQIRQEMLQALRQSGASAIFVTHDRDESLRYADKIAIIQQGKILQIDTPRTLYWSPNHLETAKFMGESIVLPANLLDENTAQCQLGNIPIKNKSISQNQGRILLRPEQFSLFKTSENPTALFNGQIKQIEFKGKITSIQIEINGYAIWIENVISPDLSIGDNLPVYLHRKGLFYS
The following text describes a protein:
Function:
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
Subcellular Localization:
Cell outer membrane.
Sequence:
MKQGKSFIFYCLVLLLCGFQQLSSAVTASIAKAIKTTDRKQRVSETLPTGLSYRRFYQHIAHLLGWVPAPDLVCRGYFKEPLILTEHPHPGPATKEPAIVTAKGPSMVTAQGVSILRKDVVVTQPGRIVEADKAYIYRDSKTGHVTKIILIGHVRLHEADKRIVADKGTLTLYPKTAILMNAAYHIYNGEPYFYKFKYPFDAWGIAKHAVRDASNVITLRHATYSTCKPTAPAWSMSATTLVLNRNTHRGEAYNMLLHIGRVPIFYFPYFNFPIDNYRKTGFLIPYAGHSSSSGWFFALPFYWNMAPNYDLTLTPEFMSERGLNLQSLFRFLSTKSSGTIYLNYLPNDKVFQQFRETTLSKFPPSVLAEHPVFIPYVDKLKKMKNQRAFFSMNETTLFNSEWSSRVILNYVTDPYFFQDLGGQLGGSSLANQLLNQIDLQYNGLHWQFMGMLQAYQTLHLISQWTTPALDQYSRLPDFNIVGYYPDIARHVDFNFNAEAVNFDYRSDFVPDKPRGQRFHMRPGISFPFYFASGYIIPQLWADATAYNITHFQPGQAHTSSRLLPIFDIDSGLYFDRNFHLGHRSFIQTLEPRFFYLYVPYQNQDRFPNFDTVLLPFSFEQLFALNQFTGNDRLQNANQASFALTSRVLDAQNGSPILTANVGFIYYLENQRVCLTPGCTPSNYHYSPIIGELTFYPFPYWSFTGSLAWDPNLGQTNNTSVELAYNNGGKKADIRYLFVHGNEDSIVTPTTLIVPGNAYSQNTNHVISSGAWPLLKKWNAVGYWDYNITERRTDVYSIGVQYNTCCWALSFSIRRTYAGLKVDPNGALQRQYDTAYGFELQLKGLGNLGTAPISTVTVLDAMNNGVSNDVR
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKVLTTSEEDLTIAAKQINAGGLVAFPTETVYGLGAHLEEKALAQIFAAKHRPYSDPLITHFATAEAAKKYLILTDEESANFDKLAAAFWPGPMTLVAPATKAVPPLVMAGTGCVGVRVPSHPIAHRFLEICGEPVAAPSANLFGHVSPTTCDHVMYDLGQTPDLLVISGGNATIGIESTVLRLHGKNITVLRPGFITAGQVEQVIPGSVTRDAGVQEKLASPGHETRHYAPNMPTYLVRKQGSKDAVEQTVSLTPDTVLIDFNRTFSTASSQVLRYFDLSPVGNVADAVRNVYNVLRDAEVTPGAKQCIIADILESGNHDDTHDNELCNSLRDRLLRSASHQIRTLIL
The following text describes a protein:
Function:
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Miscellaneous:
MISCELLANEOUS: Tyrosine phosphatase activity has not been demonstrated for this protein to date.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Note=Localized to the cleavage furrow and the midbody during cytokinesis (By similarity). Also colocalizes with F-actin in the cytoplasm and the cell periphery, which may allow local control of actin dynamics at sites of cell locomotion.
Sequence:
MALVTLQRSPTPSAASSSASNSELEAGSDEERKLNLSLSESFFMVKGAALFLQQGNSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESVWTDRVRYMVVVYTSGRQDTEENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWSALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKEFKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQPTDDTIAEPSEFLPETLDGALDAQLPCLDDTTHPGLPRSLAPGGPALPCCFRRLSDPLLLPHHDETGGLVHLEDLEKDALLEEEESQPVEVHKLVQHPQEGARLCEKDVKRKLEFGNSKPRSDSLPQVEELEKDGSPRTGRWRRASTQLDRSLLDQENLNNNNSKRSCPDDLERDAMFGILSKVKPPYTSCADCMYPTAGGTPEAYMERHEDPSSSAICTQPTFLPHVTSSPMAHASSRSRAPERPASGPANTSPFLLPAGSRKPDVSGSGAGAAPEPPASLLEPSRETSKALPKSLQLKNPHCDKNAANMEVSAKEEPSPKKDPKPAKDLRLLFSNEAEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSLPSDSPAACRDSATCRLEASIPEEGSQEPAHPALCSQAGSEEQPVGGTLQKSPTSTLPRLDHTSNFSKDFLKTVCYTPTSSSISSNLTRSSSSDSIHSVRGKPGLVKQRAQEIETRLRLAGLTVSSPLKRSHSLAKLGSLNFSTEDLSSEADTSTIADSQDAKCGLSSSFLPEPQSAPRDPAATSKSSGKSAPEHLKSPSRVNKS
The following text describes a protein:
Function:
Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
Sequence:
MEDAVNEYLLSFIDPKDKLILEMEEYATENHVPIMDRLGMEFMLQFLRLIGPKSILELGTAIGYSSIRMMQAIPNSRIVTVERNRERYEKALEYIERSPVTDRISVIYGDALETGEQVKEHGTFDVIFIDAAKGQYRRFFDLYEPLLNPGGVIISDNVMYHGLVTTKEKIENRRTRGLIRRIKTYNEWLMNHEGYDTTIFPIGDGVAVSKKRG
The following text describes a protein:
Function:
Controls the proximal-distal patterning in petals and the adaxial-abaxial determination of leaves. Involved in the repression of the homeobox gene BP.
Sequence:
MASSSSPCAACKFLRRKCTQECVFAPYFPPDQPQKFAFVHKVFGASNVAKLLNELASNQREDAVNSLFYEAEARLRDPVYGCVGLISILQHRLKQVNHDLENAKKELATYVGPQAMLPILQPHFMSLPPQPQRPSSSSASVLTQHHHNLLPMMAIPTGQLYHQQQQQIFEAQQLAAVAREQQNEMFRAYGGGGGSSSPHHQNQAQAEILRFNNGFDSVPAGSVTVTGFNQLSSGGTAVTGMSLGGNFVDSPSTNNNYHTDQQLHHHHQPQQHHEAQLFIPSQSSQPLPLQTQETQTQTQPNSESEEGRRNVIG
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MPDSALPPCSILLLAGGRGQRMGGRDKGLIEWQGLPLIAHLHRLVRPLTDDLIVSCNRNQERYAAYADRVVSDDSRDFPGPLAGIRAGLAVARHPWLLVLPCDAPRIDRALLETLLQAAGRTPARPWMLRCGGQWEPLFSLIPTHLAEEIEHAWRQGDRSPRHVLLPLGAEAIELAAGDPRLANLNTPELLANHRELK
The following text describes a protein:
Function:
Required for initiation of chromosomal DNA replication. May have a role in regulating the MCM proteins nda1 and nda4.
Subcellular Localization:
Nucleus.
Sequence:
MFIKRSDYASAYLKIKEASVSGGCTVQLFVALDPDALCACKLLSTLLKGDFISHKIRPVSGYRDLEQANKTLLEQNEDIKFIILLNCGTMVDLNNYLVSMEDVSIYVIDSHRPHNLNNIYIENNIFVFDDGDIEEDMNKIHDAWYAFNSHELSDEENSDSSNEREEEVEDDNRSVESYSSSDYQARSRRRFSEETTQRRAEIKEKRKKRKEFASILSEYYEKGSWYGESITNILFAVASMLGREDNDMLWLAIVGLTCLEIHCQSSKKYFNRSYSLLKDEVNRLNPSPLENQIVGRAHGKTPHDQSIRLEDEFRFMLVRHWSLYDSMLHSAYVGSRLHIWSEEGRKRLHKLLAKMGLSLVECKQTYIHMNMDLKKTLKSSLKRFAPFYGLDDVIFHSFTRTYGFKCTLSASDVSYAISALLEMGNTGVLLQSKTVARSPDMTEEEYLEKFENAQNQEWLHNFYDAYDALDDVDSLERALKLAMHLQRAIVRTGITLLEKRAIKTLRSFRFGLINEGPDLKIFMHPLALTKMSLWIAEAINEQEREFGKLRHLPLVLAAFVEEKNRYLIVGTSTSAFTSNEDDDDDDGHGHNRFGVAFQEVANMTSATLQMDCFEASVIECQKSDLGVFLESLSFKTLL
The following text describes a protein:
Function:
Serine protease.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MYRPVIASRKSIPPWLIILCVLGVLAALGIIIGLLVHFLAVENKIYYYQGGFKVLDIPYDRNYERETSLESNYLSKILENKMVEAFQNSNIYKQYINSQVITLVPDNNSVTAHIWLVFKDPWSNKENLRRRIESILRQMLENNPESLTTDPGSLKLTEISKVDAEKIINNRCGRRPRMSATYDRITGGSTAHKGEWPWQASLRVNGKHYCGASLIGERFLLTAAHCFQGTNNPKNLTVSFGTRVTPAYMQHSVQEIIIHEDYVKGEHHDDVAVIKLTEKVSFNNDVHRVCLPESTQIFPPGEGVVVTGWGSFSYNGKSPLLLQKASIKIIDTNTCNSEEAYGGRIVDTMLCAGYLEGSIDACQGDSGGPLVHPNSRDIWYLVGIVSWGHECGRVNKPGVYMRVTSYRNWIASKTGI
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNNVDYFCRKCIVSTSLYLTHVKKLTKFDLYMSMHGMKLIYLLFLFFSLTFKKVLQKKNIEGFSCIPYIMAMFNCLLYTWYGLPVKVNGCLLVPALLLFVGVALTSTFSFHNHRTRKILVGSFGLVASVLMYSSPLVAVKQVIKTRSVKFMPFHLSLFTFIATSLWMAYGLVTHDLVLAAPNMVGCPMGLLQLLVYFIYRNKTPEFEQPPLKVVDLEKNGSDITPAAPIIPA
The following text describes a protein:
Function:
Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of chaperone and assembly factor genes. Component of a feedback loop involving atfs-1, atgl-1 and hlh-11. Acts together with flp-7 to negatively regulate the expression of the transcription regulator hlh-11, to promote expression of atgl-1, and thus atgl-1-dependent fat oxidation in response to mitochondrial stress. In addition, functions with hlh-11 to maintain lifespan. Promotes mtDNA maintenance and propagation of deleterious mtDNA.
Subcellular Localization:
Mitochondrion matrix. Cytoplasm. Nucleus. Note=In absence of mitochondrial stress, localizes mainly to mitochondria where it is rapidly degraded by protease lonp-1. Upon mitochondrial stress which causes a reduction in protein mitochondrial import, accumulates in the cytoplasm and translocates into the nucleus to activate transcription of mitochondrial unfolded protein response genes. Similarly, accumulates in the nucleus in response to P.aeruginosa-mediated infection.
Sequence:
MFSRVGRLTTFGAQAVSNCPFRRDNIYQQPLKVTAPINDQLTSFAHSFSDSVRHRTTSFGNDPFLGVPMDDDEVIKELELLDLDSWHTKPRAPCPAPSDELELDQFWEGKNVTVCGRDPRLGKSTDCFELEAWRPTDSWQNGSSVGHPHGHQQQQQTCQQPPTHSSTTETMHDFSNFGDNMGSPLFQSPSKSAIDQLTGTSRIDEYGMPPQDRKLSKFEMDIEQESKAVDWEAWNHYLESDDDVFKRPEAFFKEEPMIMTSSDSLMTSSTSSPDSGISLYDPMIPPPSSHFPSFNLSSSSSASNLLRLSTPSAPMQQEHRAPVRMHHDVDLFSSGPLLCVPKQEDVFDDFIQQRDDDDEDYIPASEARRTSSRLNRKSATPTYLRRRDSERSWTPASDDYFPEEHQKFKKRGVVLKPSVDEETDRRRMLNRIAAVRYREKKRAEKKGRKMEFQEVADRNRILLQKERQLKREINSMKKELRKMGAIIQ