lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
5'-hydroxyaverantin dehydrogenase; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins. The first step in the biosynthesis of sterigmatocystin is the production of hexanoate by the fatty acid synthase (FAS) units stcJ and stcK. The polyketide backbone is assembled by the non-reducing polyketide synthase stcA by condensation of the starter hexanoyl-CoA and 7 malonyl-CoA extender units followed by cyclization and release of norsolorinic acid (By similarity). Norsolorinic acid is the first stable intermediate in the biosynthesis of sterigmatocystin and is converted into averantin (AVN) by the ketoreductase stcE which reduces the hexanoate ketone to an alcohol (Probable). Averantin is then oxidized into 5'-hydroxyaverantin (HAVN) by the cytochrome P450 monooxygenase stcF. 5'-hydroxyaverantin is further converted to 5'-oxyaverantin (OAVN) by the 5'-hydroxyaverantin dehydrogenase stcG. The next step is the conversion of OAVN into averufin (AVF) which is catalyzed by a yet to be identified enzyme. The cytochrome P450 monooxygenase stcB and the flavin-binding monooxygenase stcW are both required for the conversion of averufin to 1-hydroxyversicolorone. The esterase stcI probably catalyzes the formation of versiconal hemiacetal acetate from 1-hydroxyversicolorone. The oxydoreductase stcN then probably catalyzes the biosynthetic step from versiconal to versicolorin B (VERB). The next step is performed by the versicolorin B desaturase stcL to produce versicolorin A (VERA). The ketoreductase stcU and the cytochrome P450 monooxygenase stcS are involved in the conversion of versicolorin A to demethylsterigmatocystin. The Baeyer-Villiger oxidas stcQ and the reductase stcR might be involved in the biosynthetic step from versicolorin A to demethylsterigmatocystin. The final step in the biosynthesis of sterigmatocystin is the methylation of demethylsterigmatocystin catalyzed by the methyltransferase stcP.
Sequence:
MEPLDLTCDLTSLNGKSAFITGGASGLGLATARKWAEAGVYITIADIQPPTSPVQPGLAHCFHYVYCDVTSWESQVAAFKSALRFSPSGALDIVACFAGTALAPGNQIDHVLAAGVPSLEVDPPRPSSSVRNIEVNLVGSYFTSWLGLYYLRIPGTGTDPELPSNKCLLFCASIAAYMDSPKASTYPASKFGVRGLFRSTRSQTKQLGVRCNLLAPWFFDSPLIAPIKHAMAARGVDMAKVLTFTSIDACVDAATYCVASPEIHGRALAVQPEGTFDLKDDLEDGWGGNQLRPIMQRRRDAGFDV
The following text describes a protein:
Function:
Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
Sequence:
MASRLLHRLRHALASDGPGEAAAGPEAEQFPESSELEDDDAEGLSSRLSGTLSFTSAEDDPDDEDEDDEAGLDSPPSGDGASGEDAERSPPPDGQRSSQLLARQLQDFWKKSRNTLVPQRLLFEVTSANVVKDPPSKYVLYTLAVMGPGPPDRQPAQISRRYSDFERLHRNLQRQFRGPMSAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELRQAPDLQDFFVLPELRRAQSLTCTGLYREALALWANAWQLQTQLGTPSGPDRPLLTLAGLAVCHQELEDPGEARACSEKALQLLGDKRPHPFLAPFLEAHVRLSWRLGLDKRQSEAQLQALQEAGLTSTPPPSLKELLIKEVLD
The following text describes a protein:
Function:
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.
Subcellular Localization:
Membrane; Peripheral membrane protein. Secreted, cell wall.
Sequence:
MHLQFSFYLRLFCFGIAMKLAMLPAATAVGQLQHHTLDLHWYPGTATWYGDPEGDGSTGGACGYGTLVDVKPLRARVGAVGPVLFMKGEGCGACYKVKCLDNSICSRRAVTVIITDECPGCPTDTTHFDLSGAAFGHMAISGENGQLRNRGQIPVIYRRTPCKYPGKKIAFHVNEGSTPFWLSLLVEFEDAEGDIGTMHIRENGSSEWLQMNHLWGANWCIIGGPLRGPFSVKLSSSTGRTLSARDVVPSNWVPKATYTSRLNFYH
The following text describes a protein:
Function:
Required for the A-I editing activity of the double-stranded RNA-specific adenosine deaminase adr-2 by facilitating adr-2 nuclear localization.
Subcellular Localization:
Nucleus.
Sequence:
MSFASGCTPVSFDKLFEVSSGDKVSRENWGMIARPEPQHDSLKRRNTTSSIAKKKAKMTRGDEQITDETARKAATQLLDQIQDTPGRISLNFETPEAASVCPIPTSLNQIVNTKWTVNQLQEGQLTMLLAQDANKFKSLGVKNIKKGSVETQILPRQMDVKEIVEKLKKQDNDSDQFVGYAAAVANVLRRCDAETAQKITQAITATIEKEAPSIVNC
The following text describes a protein:
Function:
Activator of specific mitochondrial mRNAs. PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3.
Miscellaneous:
MISCELLANEOUS: Present with 799 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MKASSKAIKLVLDHLKSTGRVLGSVESGNSATISEKTASVNKQQQLQEKKPSVLQYRSYNPYLVKEDFLSILPENLYKKRGQFTNELDFQLMKVRDPKYFQFKDQYYLFFNDYNSLTEYIKLTKHSRINKIRVKMTPLAQPLPTLLTKLQRYSKNLYNAFRSSEQYFEGLNEKVDVSGEFTTNQLRSILDSVEEIENKSVLVWNIPTKLRSHDILNYFWFYNIRSSFKIYWDDEMKRNLRFISFENSHDAYRFKRNYHGLLAKELLTLSEKGDAADYSLEMDDSKILIEHLSE
The following text describes a protein:
Function:
VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
Subcellular Localization:
Secreted.
Sequence:
FIDSSQDSPVKRHSDAVFTDNYSRFRKQMAVKKYLNSVLTGKRSQEELNPSKLRDEAEILEPSFSENYDDVSVDELLSHL
The following text describes a protein:
Function:
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
Subcellular Localization:
Sarcoplasmic reticulum lumen.
Sequence:
MKWNLVFLGLLLTFGQLSWGQKGMDIPEYDGKDRVHELNAKNYKSVMKKYDVMVVYYHEHVGSSKVAQKQFQIEELALELAAQVLADFDDEDIGIGLLDEKTDKAVAKKLGLDEADSIFIFIEDEVIEYDGELAADTLVEFIYDVIEDPVEIIGNVREMKGFNNIEEDIKLVGFFKSAKSDHYHEYEDAAEEFHPHIKFFATFNPKVALKLGLKLNEVDFYEPFMDKPVVIPGKPYSEKELVRFIEDNDRPTLRKMQPHNMYEIWEDALDGEHIIAFAEEGDPDGFEFLEIVKEVAEDNTENPDLSIIWIDPDDFPLLVHYWEKTFDIDLSSPQIGVVEVDDAESIWFDMDDDDMPTVDELEDWLEDVLENKIDPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
The following text describes a protein:
Function:
Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.
Subcellular Localization:
Nucleus.
Sequence:
MTDQDSTYRPRSPDLSTFQSSIPPAVNSPIYPLASPLAHRASYDASPFFAPQYQQPPAPLGRVPQQYIPPFVDPNSPLSPDMARRSSRLARATEVAPMPEVSYAQPVLSEEPQQLPPPPPQPNPVASIEVKTKFPVARIKRIMQADEDVGKVAQVTPIAVSKALELFMISLVTKAAKEARDRNSKRVTATHLKQAVVKDEVLDFLADIIAKVPDQPAGGRKHDDDGSDQNEQPKRKRGGRRPKDDSD
The following text describes a protein:
Function:
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Sequence:
MEIIKISPRGYCYGVIDAMVIAKNASLDPNLPRPIHILGMIVHNKHVTDAFESIGIYTVDGANREEILDKITTGTVIFTAHGVSPSVKAKAVAKGLTTIDATCPDVLHTYNLILEKQAAGYEIIYIGKKGHPEPEGAYGTAPDVVHLVETKADIDALSLLSDKIFVTNQTTMSKWDVADLMHYIKGKFPKAIQHQEICMATQVRQEAVALQAKDADLTIVVGDPRSNNTARLAQVSIEKAGTKAYRIADITELDIEWIKDAKKVAVTAGASTPTQLVREVLLFLEQFDAADKTTWKREHNQDFERILPKTKNKYMAEKRSQRLAHLKNGGS
The following text describes a protein:
Function:
Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3'. Binds to the HMGN1 promoter and may repress HMGN1 expression. Regulates SNCA expression in primary cortical neurons. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9. Plays a role in chondrocyte differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MEGSRPRAPGGHLAPSPPAFDGELDLQRYSNGPGVSSGSPGMGAVGWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRPRSSGGLQATPATEALGRPQAPSSSAFRCPFCKGKFRTAAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPDRPLAATSAAPQPQPPPQPEARCVPEPDPEPEREATPAPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPGSGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEARPNGEGAEPGAGRSFGGFRPLPSALPARARRHRTEEPEEEEEMVETEEETWARSRALGPLASLPPRPGEGSGHNAPAAGAQARSTTTQEENGLLVGGTRPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQKSGAGPGPPPEPPPSSQRGSAQSSGPKPAPQPATWVEGTASPRPPSRGAAPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARPPSGETPPSPPQEGEEGPGLLRSGEAGLGGQER
The following text describes a protein:
Function:
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.
Sequence:
MPNNETEASMRNTLFPTLKWSLLVLMTSLLTACGFHLRGDYDIPQELSRMSLTSYDQYSTFTRMVHRQLRLNKIDLQAPAEDLPNLHLLSESTGERTLSLYQNTRAAEIELTFVASYRVTVPELGSRTFTTSVTRSYLDNPLTALAKSVERDMIEDEMRKLAASQIVRQMARLKADFARKTLDDESIEGKGITDYRVDTQEVANPVSTEGSSE
The following text describes a protein:
Function:
Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Peripheral membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Anchored at the ER, PM binding is mediated via GRAM domain and phosphatidylinositol lipid interaction. Localizes to distinct EPCS than GRAMD1A.
Domain:
GRAM domain is required for specific location to endoplasmic reticulum-plasma membrane contact sites (EPCS). Mediates interaction to phosphatidylinositol lipids and binding to plasma membrane.
Sequence:
MTALSRSEATEEGGNQQMHRKTASLNSPVSCKEKPDRVEEPPDYSLHWPEGLKGEEIKKCGREGITLNKYNQQYHKLFKDVPLEEVVLKVCSCALQRDFLLQGRLYISPNWLCFHASLFGKDIKVVIPVVSVQMIKKHKMARLLPNGLAITTNTSQKYIFVSLLSRDSVYDLLRRVCTHLQPSSKKSLSVREFSGEPESLEVLIPEMKWRKVCPSSRSLSLPDNIPCIPPSSVDSTDSFFPSRKPPMSEKSRAQVASENGGRWAWPMPGWGPACPKKMPNCSPTAKNAVYEEDELEEEPRSTGELRLWDYRLLKVFFVLICFLVMSSSYLAFRISRLEQQLCSLSWDDPVPGHR
The following text describes a protein:
Function:
Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MAGAREVVTVQLGPYAGCVGAHWWALQESSFSSDPATARSDETLHHNVLFRPGRSSQGQETYTPRLILMDLKGNLGCLKQEGTLYHDTNTDTPVAWKGALTTHREDPSPVHPFLKGLGGSEDNRSSGSGFSPRTLPGGKDVYAERRNETPETLPSETTAHVWSDFLRTSLHPRTTFAIQQYSHEGDSSQLEAFGQGEKLLQSAAYAEELEDRLHFYVEECDYLQGFQVLCDLHSGFSGIGAKLTELLQDEYAGKGVLTWGVAPTHKSAVPQKNFYRLMNTVLGMVSLSSHSSLLCPLSLNGSLGLRTEPPATLPYLRYDVSARAWLQKQCAVQQDLPLRVGGSFKLVLFCYYHKQVAASMAAVPFPVMRGQSLPDALCSQQLAAPWSSMSSCGEQSKSHCFAQSVVLRGISKEYQVSRPPSGTEPKSVLHMCDTGQEVLARYLYMASPRTFSTSHLLQSPTRLLAPYPQYFSPLLNKQGLLLEKPPLHTSAAVESIPVFTALQSSAVLRRTLGNLYEELHQVDVRRWASFFSAGVESDDFQEALEELRTLSHCYRHSDAAEDSEDDLD
The following text describes a protein:
Function:
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Sequence:
MMLTLPFRNFIKKAANRTLQNSLLLRAKSTKEEKSEAEKSQEAALEEKLFLVDENDKVIGHASKRECHQVKKDGEIPLHRAFSVFLFSSHGDLLLQRRSEEKITYPGLYTNSCCSHPIVDIEGEGEECDALGVKKAAQRRLGFELGIPKDKLPLEKFNYITRVHYKDEGNGEWGEHEIDYVLFFQGDVPVNPNPNEISEISYVPRHELDQHLPTLGTLTPWFHLILKHRLKLWWDNLDKIDKIIDHEKILKLGFPK
The following text describes a protein:
Function:
May be involved in ventralization.
Subcellular Localization:
Nucleus.
Sequence:
MRLSSSPPRGPQQLSSFGSVDWLSQSSCSGPTHTPRPADFSLGSLPGPGQTSGAREPPQAVSIKEAAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTWFQNRRMKHKRQMQDPQLHSPFSGSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQALMLPPGSFWGLCQVAQEALASAGASCCGQPLASHPPTPGRPSLGPALSTGPRGLCAMPQTGDAF
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Sequence:
MLLCKTVYKPWMQGFNRSFLRFIHSKKSINHISFIKDETTCVSYNDVDSFQNQIVSQFLDFKAGKIGEHPKATFLSMQFHPVYTLGRRQRNTELINRLQAGKADVVQALRGGQTTFHGPGQLVVYPIVDLIDLQIKPRTYVSMIEQSVINTCEHFGIHGTHTTENTGVWVTDDDKIAAIGIHLRRYITSHGVAINVNTDLRWFDSIVACGLKGKRTTSFEQQGISVSIKDVESYFIKTLWNTMSKK
The following text describes a protein:
Function:
Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion.
Domain:
Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.
Sequence:
MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSESTITISLYIPSEQQFDPPRPLESDVFIEDRAEMTVFVRSFDGFSSAQKNQEQLLTLASILREDGKVFDEKVYYTAGYNSPVKLLNRNNEVWLIQKNEPTKENE
The following text describes a protein:
Function:
Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Subcellular Localization:
Nucleus.
Sequence:
MASRTATKDIITLRGSAAIVAEFFGYAANSILYNRGVYPEESFAKVKKYGLQMLLTQDEGVKTFISNLTAQLSEWLEAGKLQRMVLVIMSKASGEVLERWNFSVETDSEVVEKGVSREKSDKEIMREIQAIMRQIISSVTFLPCLEEPCVFDVLAYTDTDVAVPFTWIESDPKLIANPHMVKLHSFDTKIHKGKPTLSPSSIRYVVFFPLSRLSKRGAHFKE
The following text describes a protein:
Function:
Catalyzes stachyose synthesis by transfer of a galactosyl moiety from galactinol to raffinose. Also catalyzes verbascose synthesis by galactosyl transfer from galactinol to stachyose or from one stachyose molecule to another. Oligosaccharides of the raffinose family play a protective role in maturation drying of seeds. They may act as cryoprotectants in frost-hardy plants.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPPLNSTTSNLIKTESIFDLSERKFKVKGFPLFHDVPENVSFRSFSSICKPSESNAPPSLLQKVLAYSHKGGFFGFSHETPSDRLMNSIGSFNGKDFLSIFRFKTWWSTQWIGKSGSDLQMETQWILIEVPETKSYVVIIPIIEKCFRSALFPGFNDHVKIIAESGSTKVKESTFNSIAYVHFSENPYDLMKEAYSAIRVHLNSFRLLEEKTIPNLVDKFGWCTWDAFYLTVNPIGIFHGLDDFSKGGVEPRFVIIDDGWQSISFDGYDPNEDAKNLVLGGEQMSGRLHRFDECYKFRKYESGLLLGPNSPPYDPNNFTDLILKGIEHEKLRKKREEAISSKSSDLAEIESKIKKVVKEIDDLFGGEQFSSGEKSEMKSEYGLKAFTKDLRTKFKGLDDVYVWHALCGAWGGVRPETTHLDTKIVPCKLSPGLDGTMEDLAVVEISKASLGLVHPSQANELYDSMHSYLAESGITGVKVDVIHSLEYVCDEYGGRVDLAKVYYEGLTKSIVKNFNGNGMIASMQHCNDFFFLGTKQISMGRVGDDFWFQDPNGDPMGSFWLQGVHMIHCSYNSLWMGQMIQPDWDMFQSDHVCAKFHAGSRAICGGPIYVSDNVGSHDFDLIKKLVFPDGTIPKCIYFPLPTRDCLFKNPLFDHTTVLKIWNFNKYGGVIGAFNCQGAGWDPIMQKFRGFPECYKPIPGTVHVTEVEWDQKEETSHLGKAEEYVVYLNQAEELSLMTLKSEPIQFTIQPSTFELYSFVPVTKLCGGIKFAPIGLTNMFNSGGTVIDLEYVGNGAKIKVKGGGSFLAYSSESPKKFQLNGCEVDFEWLGDGKLCVNVPWIEEACGVSDMEIFF
The following text describes a protein:
Function:
GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity); Functions as a GTPase. May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Nucleus, Cajal body. Note=between the cytosol and Cajal bodies via a XPO1/CRM1-dependent export mechanism.
Domain:
In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Sequence:
MGKKRGTGLGRSLQRQRGSERRGASSWLHASEVVGESGPERRSAVEQSPLEEFLATAELAGTRFVAERLNIQFVSAQSRTGLLTAQEAQHVRQLHEENRQFLRIPRRPYWDRTTSSEDLKQAERESFLEWRRQLAHLEEEKKLILTPFERNLEFWRQLWRVIERSDIVVQIVDARNPLLFRCQDLESYVKEVSNDKENMILINKADLLSEEQRAAWAQFFEKEGVKVVFWSALAECRRLSGEVKELDADSVADDLSDSEEESSSQEEDVTAEDSAESTSTGSALQTENQCLLSDDDSSDEYEDCEDEEEDDWQTCSEDEGGDKVNAIAPKSMENRTDIVSMHHVVQEQNRNVKNFSHLVQRNELLEIFKTLHSGPRVKDGEVNVGLVGYPNVGKSSTINTILGDKKVSVSATPGRTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMICSGILPIDQMRDHVPPISLVCQHIPRNILEATYGINIIRPREDEDPDRKPTAEELLTAYGYMRGFMTAHGQPDQPRSARYVLKDYVSGKLLYCHPPPGIDPDGFQHQHERCPESRTVQASGPVKPKKNTKAKQIENVVDKSFFHQENVRALMKGVRATMGYRPGSGLVSVPAPSAGSVVGKPWKKHGNRNKKEKVRRITKHLEN
The following text describes a protein:
Function:
May be involved in telomere capping.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MWILIYLFIIWSSLRTWVTAVDSTTTVGDDLNETVSASVWPTMSPQMTVAFRSQRDVMGNLTIDQLPYVGLNLRRVLLNNETSMVNEGNNTRLLTLFKSMLSSEANAFVLDLEQYNNDLRVVDTTLLFSDVLTALQSFIFSTQNNLYANIIVLLLNISAPELDSTEYRHQNQTLNTTYILDKNLGNSFIYKPTDLQSDRAKNNTWNIYGKSSIDGWPTLGSVLYEQKKRLVIGELTDFFNETTAPYIFPHDVFHYEQGNSTLDCPSTVEGLTDLSSIHWRFLDSLFNSVDIKEYISCGLSPIISNSAYVNNVTQLADIIHEGSVWSWDSDQPSVTQSTSKSGSSSGTLEAYNCVLLYYFANNETVTWRVGNCYNSNIGLCRYENMAFRWLVRSNKATYFDFDSYQGSKCPDQYSFNIPRSPLEQRSFIAYMRNSSFSDTQIWIDLNSISVSNCWVSGGPYASCPYEKVISRRNFVTMMVPASVCSFALLCIVVYLSVLRVPIYDNRKNWRRVINKISKSELEGVPS
The following text describes a protein:
Function:
This isozyme seems to be implicated in olfaction. Active in the demethylation of erythromycin as well as benzphetamine.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MDLIPNFSMETWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYRKGFWEFDKYCHKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKENRMKEKEKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA
The following text describes a protein:
Function:
Component of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription. The PKD1L1:PKD2L1 channel complex is mechanosensitive only at high pressures and is highly temperature sensitive. Also involved in left/right axis specification downstream of nodal flow by forming a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. May function as a G-protein-coupled receptor.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
QAILLLKVNGVYATRDLGFQIHAFSENTPSVIVDFGDGSPGICNSAREETYEVEITAHHHYKKGILQLFLWYLSRIYCLLENFRLRLFFCLSKLQYIHYVLFSFSEGIYMIRVIAFNEFYRIEDELGPYYVEMAPESLSLSMNSSGIQKDEPILFTASLMKGTNFSSVSSYNVTLTAWNRVGICQTWTLVTVLDSIQSISIFTNGTVFATDTDITFLALTTETNPLEFLWSFGDRSPPERTTSRSITKRYNFPNSYQVMVKASNKISSITSDPHSICVQRKIVPNRLVSGSSVLINSSLSFECRINFGTNVTHLWNFGDGSIRPGKSTESHVYTREGEYTVEVLVVNKVSSASLRKQIFVVREPCQPPLLQSMGPGRIQIRRHETVTLQVTFAAPIMCNISRGLRYRWILIKSNGFLMPLPPTTDTHKQTVLLPRYFLDYGNYSAIAKVQIGGSMVYSNYTVQMEVLPSDLVSTISEGTHLFVPRTASLIITLNGSESYDPDNPGARLQYHWKCAPASRQQQVCFNSSGDPPFNSRAPVISFPATLLDNTYDQFLVTLTVSSGHRTSSEAQLFLSVSSDLTSFAFCRSVHISWVSFKGNSGNWNEELSFKVTCEDCGQILDASYNWNLYLINATEPNDSEGRNYCLFFIVNTSYALSLATLSENIQKHLLDQKSKHFDFEVLKCAMTTIFLNIYLIYFLGYTNSISGPVINEETNSFSTEEEGYNLIDSFYSTDSAGSSLMVDWSKSPIDTDVFQSFTSSGKFHLMLSSNHNLLGKAQLYFAVNEIPQGMTCQVQPSNGSEANTVFSVFCTSGQADFHYEFSYSIGNSSRMPLYRGRDIQYYFTLPAGEPLDDYRVTIYTEVTNGRGSKSQPCAVDVTVLPRFVRSSYSSGLKNLSTLLLMGSYTEIRNYVTVLTRVLNRLYAEDRDTDPDKPSQIRSALISSVCNLPFQEQEELTDSVLMLTDLISTATEVTFSSAVQIIKYVKQFTNHNTFSGIFVLDKELTTKLVFLASGVLKISEQEESAHAEYLMSEGSKVITDVTLISISTGQLELQTTLHSTFRRTKLTVGSTKFHLPDALDQQVIPRSGLFQQCFISQIIYFRKNPYFWRTAPVQIAGDAADLSLYSCASRRKINIQRLVNPVTVEFERKDTENNEKRTIFSLSRDKMNFHQFRWLPKSSQESLQITVEFSKPTSRTFPVLLLVRFLEKPTPLLFNVKQTHFWDHQVVQIFIPAVALKSPGSGYLSLLDADYNRKPQNKYFTSIANYAVSVRGIQCLLWDIEREWKSGGCHPQQGTILGNINCSCNHLTTFTLISFDFPYSTGKNIFPCMFLSSFGILYVVLAIVSKFTDAHEAKKKGYIFLQDNMSTDRQQYAIIVDTGFRSQAQLSAKVHIVLYGEDGLSETRELSCPEKPLFENNSRHTFILSIPESLGPLWKIHLWHNNSGPSPSWYVSRVTVKDLMTGAHWVFPAECWLAVDKGDGRVERELTCLRRGSVFRKLLYSKFTEYLEEFHIWFSVYSHPSYSSFTQTQRLTVCFVLALGYMCFDALLTHLEPEEVGEITLTHAKHNPEKASGELAEETMSLTLFPFPRFGPSKCIIWLHLVFFSIVTCILVIQPFGVSNTFIILAIRQRSRHSRWARPPTPAQLKEAKERIRKETFLFIRNTQYTFGDLKDADGWWNWSLTTLLDSLYKDKWQNTSGPRTEVDILFYSSKLDHQSQRKIQWEGLIPFVPNISQFHLLSRTEAYSILVNLKRRRWLDMTVGAVGVQFVLYNPPTNLFTSVFLLVEFPSTGGLVPSLRIESVDIYHINSVSSYCVRVSELLFLGLILLHLCSQFWIMNQMSILSYCQEPWNWLEFSIIGLSFFLYAIHMHHFVLAVDVIDQLHKGFFQGFVDFSFIASWGQVSNFTSWVKGQIKFNSSFLLLYKSEVTHKL
The following text describes a protein:
Function:
Suppresses cell growth when expressed ectopically.
Subcellular Localization:
Nucleus.
Sequence:
MAEYKKIVLLKGLESMEDYQFRTVKSLLRKELKLTKKLQEDYDRIQLADWMEDKFPKYAGLDKLIKVCEHIKDLKDLAKKLKTEKAKVQKKKQGKCKTAVKKKGQDELSSSESLFINKESYKSVPSSKKKGKAIAKTEGEKKNKLTQDQDHLPETSGTDIKTEEDCLQNSPKPPPTSPSSSSNKKKRKEITKTEGGKKKKLTQEQAQLPEPLGTDIKKDEDCLQTPPKPPPTPPSSSLNKKRKSRREEETGVKKSKAAKEPDQPPCCEEPTARCQSPILHSSSSASSNIPSATNQKPQPQNQNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMFHATVATVSQYFHVKVFNINLKEKFTKKNFIIISNYFESKGILEINETSSVLKADPDQMIEVPNNIIRNANASPKICDIQKGTSGAVFYGVFTLHKKKVKTQNTSYEIKDGSGSIEVEGSGQWHNINCKEGDKLHLFCFHLKRERGQPKLVCGDHSFVKIKVTKAGKKKEASTVLSSTKNEEENNYPKDGIKVEMPDYHV
The following text describes a protein:
Function:
[CLE14p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Acts as an elicitor of the root meristem differentiation through the CLV2/CRN complex signaling pathway. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular Localization:
[CLE14p]: Secreted, extracellular space.
Sequence:
MKVWSQRLSFLIVMIFILAGLHSSSAGRKLPSMTTTEEFQRLSFDGKRILSEVTADKKYDRIYGASARLVPKGPNPLHNK