lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO.
Sequence:
MLLRKGTVYVLVIRADLVNAMVAHARRDHPDEACGVLAGPEGSDRPERHIPMTNAERSPTFYRLDSGEQLKVWRAMEDADEVPVVIYHSHTATEAYPSRTDVKLATEPDAHYVLVSTRDPHRHELRSYRIVDGAVTEEPVNVVEQY
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MENRNEEEELDLLLGEITFAESPILRDNRSYLLHQQLPRRNNSSVNAIQTLTGPSLESAFGRLNLSTAASSQQSSFRSIVPRGYDGVIGNPMTNSTSIGQGLLHLSFQQMQQNTIDLHRLRLQDAVMGQTTAFMRGTPTLRAETSNSFPLNRSTSTFLSREGEVKAAASVTSFENGYREPFYNCYSRNQSCFKLKRPSPRESINCFLTRPCSNGNGFHLDSEAHCGGGVINGSLFESENSNADQNPYCNRHFQQYLSLEELRGHILEVAKDQRGCRFLQKKFEEGNEEDIKMIFSEVKDHANQLMVDPFGNYLVQKLIEVCNVEQRTEILHAVTREEFELVTICLNPYGTRAVQKLLEHLTTPQQISRVMSALRRGAVTLTNNTNGHHYLLNAVADHSVEIATDRSGCCVLQQCLAHAKGEPRERLIAEITENALLLSQDPFGNYVVQYILDMHIPNVTENILNQLHGSFVSLSLQKFGSHVVEKCLKYSGVEQSTRIIRELLNSRDFFMLPQHEYGNYVVQSALMVSKGHIRSALIASLVQMHFPSMCSSPYGKWIMQWINANK
The following text describes a protein:
Function:
Involved in bacillithiol (BSH) biosynthesis. Catalyzes the second step of the pathway, the deacetylation of N-acetylglucosaminylmalate (GlcNAc-Mal) to glucosamine malate (GlcN-Mal).
Sequence:
MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAELSSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVFMPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFVIDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEGFFSKRMLMLDHDVLGGEQ
The following text describes a protein:
Function:
Involved in the biosynthesis of sulfomenaquinone (SMK, initially named S881 on the basis of its mass), which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. Catalyzes the transfer of a sulfonate group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to omega-hydroxy-beta-dihydromenaquinone-9, generating omega-sulfo-beta-dihydromenaquinone-9 (sulfomenaquinone).
Sequence:
MKALRSSSRLSRWREWAAPLWVGCNFSAWMRLLIRNRFAVHHSRWHFAVLYTFLSMVNSCLGLWQKIVFGRRVAETVIADPPIFIVGHWRTGTTLLHELLVVDDRHTGPTGYECLAPHHFLLTEWFAPYVEFLVSKHRAMDNMDLSLHHPQEDEFVWCMQGLPSPYLTIAFPNRPPQYEEYLDLEQVAPRELEIWKRTLFRFVQQVYFRRRKTVILKNPTHSFRIKVLLEVFPQAKFIHIVRDPYVVYPSTIHLHKALYRIHGLQQPTFDGLDDKVVSTYVDLYRKLDEGRELVDPTRFYELRYEDLIGDPEGQLRRLYQHLGLGDFECYLPRLRQYLADHADYKTNSYQLTVEQRAIVDEHWGEIIDRYGYDRHTPEPARLRPAVGG
The following text describes a protein:
Function:
Facilitative glucose transporter required for the development of the cardiovascular system.
Subcellular Localization:
Cytoplasm, perinuclear region. Endomembrane system; Multi-pass membrane protein.
Sequence:
MGERLRGASRPLPLLPLCASVSLLGGLTFGYELAVISGALLPLQLDFALSCLEQELLVGSLLLGALLASLVGGFLMDRYGRKQAILGSNLVLLAGSLSLGLAGSLTWLVLGRSAAGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITLGILLSYALNYALAGAPWGWRRMFGWAAAPALLQSVSLLFLPAGTDEAAAHKDLIPLQGGEATKLGLGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFRSVGFRGGSSAVLASVGLGAVKVAATLVAMGLVDRAGRRALLLAGCALMALSVSGMGLVSFAVPMDSGPSCLAMPNATRLPGLPGDSGLPRGISPPPLPTTGKRRGEPVWSTSEKTKPRAGAGNPTTPPLPALGTTFPVSPSPAPEWVLLHWTALLCMMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQRRRFALSLGHRQSAAGVQYSRIEVSAGS
The following text describes a protein:
Function:
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.
Subcellular Localization:
Nucleus.
Sequence:
MASFSRAVFVQKLSELRISQKSIVSLSRWVLEFRQNAGSVVTVWLQQFRLVTPGRKIIFLYLANDVLQNGRRGGPEFLILFATVLREAARLVARSRDEACKACFRTLLDIWQERKVYIDEFIQNLRLPLGEPQTLPPTVTEEQRPPEKQTFGAIQESEPRSVPEGPSPQPSILNLPLIEKMIRALQNLQQSASGDTGEMPTLPPEVQDASFVKRVAGTSEAKNLTELMEKKCTSLLEYSSVLVRKIDDQHNLIEMLLACTQNQYEVLVEKEKKYEESKKKYQEATQILQCLVDIST
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MHELVLSGRFVLNGEIVGGSIGIDNGLITEISRRDIKGEEVIAFKSEIILPGLIDTHVHLRDFEQKEKETVESGTKAALHGGITAVFDMPNTKPPIMDVKTFEKRLSILEKHAYSDYAASFLLAGNCGEASRARADFYKIFMGASTGGIFSENFESDYSCAPGIVSVHAEDPETIRENPERPPEAEIRAIKKALTAAEKLRKPLNVCHVSTVGGIEAIIKKNLPWVSFEVTPHHLFLTSKDFERNPLLKVYPPLRSEEHRKALWENFSRIPIIASDHAPHTIEDKEAGAAGIPGLETEVALLLDAANRGLITVFDIVEKMHDNPVRFFGIKGRDFSLGNEATFTIIDPKKEWKVKPEEFYTKAKWSPWEGKKLKGKVVMTVIRGMVVMEGDEIIEEPKGVRLDVQGGNH
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVYFQRPENALKRANEFLEVGKKQPALDVLYDVIKSKKHRTWQKIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEERTESAKESSQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSKVERLYHDIAQQAFKFCLLYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFALSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLSPEEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQSPPNRVGLIKDMVRFNALQHVVPEVKELYNWLEVDFHPLKLCTRVTKVLDWIKEQAEKEPELQQYVPQLQSNTVLRLLQQVAQIYQTIEFSRLSSLLPFVDAFLLERAIVDAARHCNLQVRIDHTSRTLSFGSDLNYSTREDAPVGPFLQNMPSEHIRNQLTAMSTVLSKAVATIKPAHVLQEKEEQHQIAISAYQKNSRKEHQRILTRRQTIEERKERLENLNIQREKEEHEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTEFGAKAFKDIDIENLEELDPDFIMAKQVEQLEKEKRELQDRLKNQEKKIDYFERAKRLEEIPLLKKAYDEQRISDMELWEQQEEERISTLLVEREKAVEHKNRMSRMLEDRDSFVSNLKASRQSVYDAKLKQFQERLAEEKRVRLEERKRQRKEERRISYYRDKEEEEQRLIEEQLKQEREDREKIENEKREAEQREYQERLKKLEEQERKKRLRELEIEEREKKRDEERRGPDDSFRKQDTPSRWGDREESGWRRGADPDERKQAPPERDWRSGGQDSKPVKDEDREGDEDSVLRKDEEQVARGDGDEERAASWRGTDDRGPKRSVEEDGGPRRGFNDEPGPRRGFEDDQGPRRGLDEDRGPRRGLDEDRGPRRGLDEDRGPRRGLDEDRGPRRGLDEDRGPRRGLDEDRGPRRGLDEDRGPRRGFDEDRGPRRGFDEDRGPRRDFDEDRGPRRGFDEDRGPRRGFDEDRGPRRGFDEDRGPRRGFDDDRGPRRGFDDDRGPRRGFEDDRGPRRGFEDDRGPRRGFEDDRGPRRGFDEDRTPRRGFEDDRGPRRGMDEERVSWRGGAEEDRGPRRGAEEDRGPRRGAEEDRGPRRGAEEDRGPRRGAEEDRGQTPWKPVVTSRPASGGWREREKAREDSWGPSHDSKPPEERDWSKRGEDGEKDSERDRRPVREESAWRRGGDDNVTPRKVSPGDKSTEDRKEPSDVRRAAPKTDEPSQWRQGEQKDSQQEERGTPRRVAAADREKPSWRTEKKEEKDAPRRPKLEEDEDGWTTVRR
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLYDTVLGIIFLSQTGVGVLGNSLLLCFPFFSSHSSRLLDPILVQLTLTNTIVLLSKGCPLVNFYLGDVYFLGNLGCQMVFYFQRMSRGLAACTTCLLSIFQAVTISPSSSRLAKHKVRVLKLIRPSCLLSWIFNVIIEVNVPFHITGSKRINSSHTGGFEVLYCYWEKVLKEVTILPSLRDILCVGGMVWASGYIIVLLYRHQRKVQHIHRRSLSQKTSPEIRATQTILLLLSIFVSAYCISCSFALYKVYKIHSGDWLVVVSTFTALCFPTISPFLLIHRDTQIFRSCCASWQKPSLHS
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase (By similarity). Mediates EXO70B1 ubiquitination. Involved in the regulation of abscisic acid (ABA)-mediated stomatal movements.
Subcellular Localization:
Endomembrane system. Note=Displays a punctate pattern. Colocalizes with EXO70B1.
Domain:
The U-box N-terminal domain (UND) confers binding specificity and subsequent ubiquitination.
Sequence:
MIHTKTGSGRRILTFPTVEPSESISIVTLLDSLIQLAGDILTFKSKHFSTNKQSFRETLRRIQNLLVVFEEIRIRIRNSRRYFHDSAAASSLKEIHVGFQKLKFLLEDCTRDGARLCMMMNSDQVSDHLRVLTRSISTSLSAFPVASVDLTTEVNELIDLVVRQARKYGVQPETNDKRAVSSINRILALFVNRVVPDPDEINRILDHVGIRKWGDCVKEINFLGEEIDAERLDEKKKKSSDQVELLSSLMGFICYCRCIILGRIERDDHHNHHEDGIKKDHDLIRGLKVEDLLCPISLEIMTDPVVIETGHTYDRSSITKWFGSGNITCPITGKILTSTELVDNVSVRQVIRKHCKTNGIVLAGISRRRKSHDDVVPESLAAKGAGKLIAKFLTSELINGGEEMIYRAVREIRVQTKTSSFNRSCLVKAGAVTPLLKLLSSVDIRIQENAMAGILNLSKHVTGKSKIAGEGLKILVEILNEGAKTETRLYSASALFYLSSVEDYSRLIGENPDAIPGLMNIVKGDDYGDSAKRSALLAVMGLLMQSDNHWRVLAAGAVPILLDLLRSGEISGGLTADCLATLAKLAEYPDGTIGVIRRGGLKLAVKILSSSEDSPVAVKQHCVGLILNLCLNGGRDVVGVLVKNSLVMGSLYTVLSNGEYGGSKKASALIRMIHEFQERKTGSVEPNLQRGRFVHAW
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MATESSRSTSSSADSYIGSLISLTSKSEIRYEGILYNINTEESSIGLRNVRSFGTEGRKKDGPQLMPSDKVYEYILFRGSDIKDLQVKSSQPVQPTQPMINNDPAIIQSHYPRPPPSSSAPTNTLPDLSIQNPPTLQSGPPLYPPGPNLGSWAPMPPPPNPNTTGLPMPMYWPGFYTPPNGVPQLHQQSLIPPPPPPHMQYPSYNGSLPGGTSNMSNSMGPTAPMEPLPTPSLVTPGQLLQSGVTSAVVSSQVTQTVHKDVEEVVQVAPTSSSSELELESSIPIPVPAQPPILPLPPQARITPKVNGGSYQNRQSYNYRGRERGRGYGGSRSVVKFTEEFDFNAMNEKFNKDEIWGTLGKTNDGNLSANDDDDDEYEDENENGADVHVSKVEAKSGVYSKDDFFDMLSCNSLDNQSNNGRTRFSEQMKLDTETFGEFSRYRGGGRGGRGGYRGGGGYSRGGGGGGYGRGGGGGYYGYGRRGGGGYNSYGGRSQNQNRDC
The following text describes a protein:
Function:
Co-chaperone that facilitates HSP-mediated activation of TSSK6.
Sequence:
MERHTSHPNRKVPAKEEANAVPLCRAKPSPSYINLQASSPPATFLNIQTTKLPSVDHKPKECLGLLECMYANLQLQTQLAQQQMAVLEHLQASVTQLAPGRGSNNSSLPALSPNPLLNHLPQFSK
The following text describes a protein:
Function:
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm.
Sequence:
MSSNNSINNSCADSVDDREMLMSVDVEAKDATKSCSIVIDAYEKEFVDVDGEAEADEGVQKLKEGAKKKRGRGLETKRYVNEYEYESMDVGVEEMNMENGPQRCQSVEGWIVFVKGINEETQEDDIREKFEEFGEIKNLHLNLDRRTGFLKGYALIEYSTYKEAEAAIQSLNGTELCGQKISVDWTFVKQPNKKSSKSRKEQRQNPPPHHRHPFSGCRWSSPNGRQTYRK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPKANKSSASAGTRKKHAAKKTHREHDDDSDHQPESGTPQPSRKQRGEKKLSKAQKRAMPKVKQYIPPPKPPAPPILDPLDGQGLARTLPADLVVVLRRLGKKDAVTRRKGLEEFRDGWVKYILKEKPTEEEETEREVKEIALLAAIPVWLHNLSGLLQSPFHRAIALLIHTDLLSVPALRASILESLNLGLLPGTQNRDVLGSWMIAALEEGRRAGGLGLRGWESSILWKASGEEVGGDTDIRIDLKEHLSTLIEYLTLSTLNPSILHEDIHPIPVAATPVSSIPLGKKGTNKQGKSKTSSAPPSRQTETPVPPPEDHEILEERMTRYRVGGLIGLSWLLQQLPQVGLTSLPEDLVTLLRHPALWLSLSSEQVDTVNSPGSLGTAQPPVRKAGYGLLDVLVNSYESIVAEPEMLKMVSNAVLSSCWREKEAVVWESAGSAIAKFIRKWPECWTLTTESAADHRDGRNDGRNDGEEEVDSEDENVQNADDEDGANPATLLQLSSPYYSDFLDFTSTICPYIPHITYPIILVVLSTLPPSLLLLVGPSLQLQTLFSHLWAPLDSRLLSTHCLPGQKSAFQVFFQAILECTIFLIGKSWKEKDGKEAAMWLVKEQLGNRAWKEGVLLMGGRAGGRHVPRGCTEESEASAFGSTLGRLASIDQLLLDQIRVVLTQTLSDACFPQENPESGPMEVSILPRSLSILSAIRDAIAASQVIGLVDQLMEDLIEKLSEVFVGSSKSDNPSHAIMAETLVDALKNHHHLVHSDTIEKLLGQVKDSSHELLIILHPPLFIAYLDSLCSKLPSAERHVCQQALSTVLQSSEIDSSQRFTVANAVLILDHTQLLQSGSLDQIVKEATHDALAGGSPIAIPVVTASLKSLCYLSKSTLDEVLSVTCSVIRESTKKLLTTDFVELGVPQAAFEIFAAYATNHLQEVIESEHLISGLVGVHHVLFVLPRLPGHIASAESKASGLLSLWSKLGELVVEYQEKVLQRVYSALKGEMGDVEVRVDPEVLIDVALATTLGSHSAPSLQALVLALLPEVISIIQDLAPHTSQPPHPSLPIVDPLIPFVPHGDDDLDSIQPEFDSLGRAQTARYAEAAVALLRADRSLVKDEPALLQMILAVSRLAQDALTVPGASRGLFSKETPSTRLADLVREVEGAVSFALGYVDEVEPSWHHATIHALKSGSVPHDSDLLQSLMVALQKEVTANGNDVDARSFRDVLYKHMRQIGAGVQEGEAWLNYAMSLVDRSPQLSLAIITAIKPLMLDTQAFATAQTRLASALTTIPPSKCHTALNLLRIFNASAPEVDSTSVFLPQQRALFVLRHVAGWLTSDDVDEDKLPEDMEFRVLELEGSVAPIVQDVGGAHWDGIFDLVENGLENSGMDDSSSLCLLYHSLSVLQQIRDLCQTNKSLRASWTSKTNHMKLVLDLFLQCRSANSVPLQLIQNLILDLLPDVPEQVMKEASLTSLCNLISLSTSSAIQTAAYRIISQVIRHQTVGLVLEVEASVAQAQEGHAERTIEMAKELVDVVKIGSEVNWHGELGVSLVLGQLLAWMSILDYFEDASRTLRWAYLDQLNTSKLITDGLVPMLFSILGVSEMGAWNFPASQYAVDEFFTEFLDPESLPDLSPLASHLFYRALVTIPSSVRAYYESLKDRQLSMSMLSFTARHYSPVIIAHEFSALREPSAMAQLTEEGLNVRIAQGGGATIAAGAGSAEAIASYVVDEQPMEIGIRLPAEFPLKGVDVRDLRRVGVPENKWRGWLMGLQQTITSRNGLILEALTMFKKNVSLHFEGVVECAICYSIISLTDRTLPTKPCRTCKNRFHASCLFKWFNSSHSSSCPLCRALF
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.
Sequence:
MSTADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLEGPHFQSNERLGRLASIARQLRSQVLQSEDEQGSYGRMPTTAKALSDDEQGGSAFVAQSHGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLCQEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSKMIAQIESSSQSSAFESLEEVRGALERSEPLLLQCPEATTTELSLCRITGMKEMLRKFSTEITLDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGRHYWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVCKVGVFLDYESGHIAFYNGTDESLIYSFPQASFQEALRPIFSPCLPNEGTNTDPLTICSLNSHV
The following text describes a protein:
Function:
Plays a major role in synthesis of cubooctahedral magnetite crystals by controlling crystal growth and morphology after nucleation. Has a partially redundant function with MamF (By similarity). When overexpressed in E.coli the soluble protein self assembles into shells of about 36 nm. This protein mediates the formation of magnetite nanoparticles from a solution of Fe(2+) and Fe(3+) sulfate; the crystals are larger and lack alternative iron oxide/oxyhydroxide species seen in the protein's absence.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 20 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)).
Subcellular Localization:
Magnetosome membrane; Multi-pass membrane protein. Note=Tagged protein forms straight lines with a punctate pattern extending along most of the cell associated with its inner curvature, in the correct position to be associated with magnetosomes. During magnetosome formation protein is first dispersed in cell inner membrane, the gradually forms foci which align and form lines as the magnetic response increases.
Sequence:
MTEAILRSTLGARTTVMAALSYLSVLCFVPLLVDRDDEFVYFHAKQGLVIWMWGVLALFALHVPVLGKWIFGFSSMGVLVFSLLGLVSVVFQRAWKLPLISWVAHRI
The following text describes a protein:
Function:
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Domain:
The domain III mediates oligomerization.
Sequence:
MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVLV
The following text describes a protein:
Function:
Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Miscellaneous:
MISCELLANEOUS: Knockout of this gene results in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm.
Sequence:
MTLESPSTRLMTCQSSLLPEKPRFLSQKMWAPHLVVAYLIFVTLALALPGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEETRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRETTISQLLIEPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILVVFSFAALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASISTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQLNTYSRAPASDYGTEPTPSGPSAPGGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MINEDSIQLDTLLKKYYEHSIEKIVFADDNGKIIAMNDAAKDILSEEDNYSAVANAICHRCEGYTNAYDVQSCKDCFLESMQVQATNFQVFMKTKDQKVMPFTATYQLIDQDRGIHAFTLQNVSSQIEQQEKLHQQRMMRKTISAQENERKRISRELHDSVIQEMLNVDVQLRLLKYQEDTTKLLEDAENIEYIVAKLIDDIRNMSVELRPASLDDLGLEAAFKSYFKQFEENYGIKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKPKGSGLGLYGMNERAELVSGSVNIETKIGEGTNVTLNIPI
The following text describes a protein:
Function:
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Sequence:
MATRIQFENNCEVGVFSKLTNAYCLVAIGGSENFYSAFEAELADAIPVVKTSIGGTRIIGRLCVGNKNGLLLPHTTTDQELQHLRNCLPDQVVVQRIDERLSALGNCIACNDHVALTHPDLDKETEEFIADVLGVEVFRQTIAGNILVGSYCAFSNRGGLVHPHTSVEDLDELSTLLQVPLVAGTVNRGSEVIAAGMTVNDWTAFCGSDTTATELSVIESVFKLREGQPTAIVEDMRKSLIDSYV
The following text describes a protein:
Function:
Accessory subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Vacuole membrane; Single-pass type I membrane protein.
Sequence:
MFSWSILFIVCFSLVSAFKDTSPIFLFSTNSKLPKSSDDSSISTCPMMFFDAAIEALSTCNTATLIIHQPGLEVNDFQLGAFKHLKRVSLQSPYSLLLPYSKESLDSQELVHSAKQNCDVEVVYLGGSFNAFPPLQNDRITVVYMNELSNESYHRSAQLMELDEMFYNLQSTLEQDAQWNVIIASSPLNNSDFEGFKVDANEEEANAEFVIQTLGGLNSGKSALQHGQLASLPDQNEGSQTTLAMHQTRKHPVTDNGATGLFTEYQFFTPGLYMGYLALAVLVPTLFISCRLLSSIQISYHAFDSPRRKQL
The following text describes a protein:
Function:
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Vesicular and vacuolar.
Domain:
May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
Sequence:
MLGQSNYLALVGGGRQPKFPQNKLVIWDDAKQKVVITLEFRTSVLGVRLSKSRIVVALLNSIHTFVFSSPPKKLAVFETTDNPLGLACLGQKVLAFPGRSPGQVQLVELETGNVSIIPAHSTPLRAMALSPDGEVLATASEAGTLVRIFATSNCAKMAELRRGVDHAIIFSLAISPSNNLLAVTSDKSTLHVFNLPHPRNAPYSNQQASSSDDGVNKKWGILGKIPLLPRVFSDVYSFASAHFELGEEEPGPTYAPPLGTVLGRPPKGVIGWSNDNTILVVGSGSDGRWEKFVLRDDEEGKKHCIREGWKKYLGSGS
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLALLFLALIVSTCPAEPAANDVALEFNALCELIGIARARDKIPKLTLGSKITKQKEFIIALNMSVSSDTFFNQKFDRPDAPTGESPEWQKNKKTWQRLQKIINDKSSGAFGRVIKQPPDTEERELAATLNNQTVAAAEALTEGEVNGPTDKEIQDLLQGAVSGKGGAAPADDTKTFGTVARSCGGNGADNTGQGKSLANDILCLCSHDSSNAGFQGCAGEGATQIITYTRESGVTAALTTVTGKCKINTTQQVTAHRLAAAITNFKALLGRHEEAADLSSMRLGKGHAGNTRDGGGAGGCILYKGLGPNGIHDIPWVKKLEGAQHLLLLRYQAIREEKTVLYGMTTLRMTAEQLHKRALLTKKRPAGTPSKEPETKNQQITDCKQHKNNKTECENAGKCKWEGENETKGECKAKQGSDTPEAGTGDEATGTTTDKCKGKSQTDCKDGCKWDGKECKDSSILATKKFALMVSSSVILVILQHYKDICSIL
The following text describes a protein:
Function:
Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MWEPGPAAACPRPRPRPRPRPRAPGPAGYVLGLDVGTTVIRGHVYDRRTHIRGSSYHKVEILYPHSGWVEIDPEVLWTQFIAVIKEAVQAAGIQMNQIVGLGISTQRATFITWNRTTGNPFHNFISWQDLRASDLVKSWNNSFLMKAIHSFSKVLHFFTRSKRLLGASLFTFTTQHVSLRLSWVLQNLMEVQRAVETENCCFGTVDTWLLHKLTKGSEYATDFSSASATGLFDPYQMCWSGFLTCLLSIPLSLLPPVKDTSHNFGCVDEQILGVPIPIVALVADQQSAMFGECCFHRGDVKLTMGTGTFMDINTGNHPQQTVGGFYPLIGWKIGQEVVCLAEGNAADTGTAIKWAQELNLFTDAAETDKMAKSLCSSAGVYFVPSFSGLQVPLNDPCACASFMGLKASTNKCHLVRAILEAIAFRNKQLYEMMQKEIHIPVTKIRADGGVCNNSFVMQMTSDLINEKIDRPAQVDMSCLGAAFLAGLAVGFWSDKEELKNLRKSEMVFEPQKKWKEYEHNMQNWMKAVQRSMNWY
The following text describes a protein:
Function:
Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MDARWWAVVVLAAFPSLGAGGETPEAPPESWTQLWFFRFVVNAAGYASFMVPGYLLVQYFRRKNYLETGRGLCFPLVKACVFGNEPKASDEVPLAPRTEAAETTPMWQALKLLFCATGLQVSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNRVLALIVAGLSCVLCKQPRHGAPMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKVSKVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPEPRSSPATTLSGLILLAGYIAFDSFTSNWQDALFAYKMSSVQMMFGVNFFSCLFTVGSLLEQGALLEGTRFMGRHSEFAAHALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYARGRLKQRGKKAVPVESPVQKV
The following text describes a protein:
Function:
Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nucleus and/or cytoplasm.
Sequence:
MSHEHPAEIVHQLQSIDSIQQDLADTAAAVVDAASQSLPPQHAAQDQKSHSTLLDNAEAMESILESAIPAAPGSSSTAAASDAIGDNNFTASGPPPISNTVVAPSAADDETGDVIVVESETPTTTNVVEAVVNPENDGDVPIESTEQSSGQPAEQPTEQPTEQPTEQPAEQPAVETPQAPQSTPAAPAASAVESIPTTLEETHLEQIVQAPAPTVHTEPLTPVVDIKMEEKPMIEHVAWIPPQGIHSDVFLPEGLTEYSPSVSQNGELIRSWRADPSNPTLLLSLFNWAVQKTEVEDARAWYRVLAVDNPTAAQPLLALINLELALSNFAEVEAIFASTLKGSAGITTAADVSIWAAYLHYIRRQNPLTEGSANAADVRSTITEAYEFALRECGFDRESGDIWDEYIKFVASGPATNQWDTQAKNDNLRKIYQRAVCIPLNNIEALWKSYDNFESSLNKLTAKKYLAEKSPAYMTARTALRELRALSDPIPKPILPPYPTFTEQDRQVVGAWKACLRWEEGNPLVIENHELLQSRIGYALRKCLGEMRHFPELWHYAASYYSKLGKQDEAAEILEAGVNACPKSFLLTFAYAELQEERKAFPTCHSLYTTLISKLNPEVDELRQNVAREIDIARGPPIPGSEKAAVAAAVGDSIDADGNDISDIQRLVEEREQRGALVAQRRGKDIEELMVGISVVWIMYMRFARRAEGIKAARGVFGKARKSPHLTWQVFEASALMEYHTNKDAAVAIRIFELGLKQFSEDVDYVIKYLQFLLSINDDNNARALFERSVVRIMGDKARPLWDAWARYEYTYGDLSAVHKLEARMSEVFPEDAPLKRFAQRWSYNGIDQIAIRDLGFNRARMGVAAPPAFAIAPVLPPVHASIPAPIAVPTPVQPPQESYKRPAPEDIPPRRPSSAEFSRSPKRHRAQSPPRRYPERDDRPPPGRYRDSLPPVKAPSSIPPPPLAGPAYATPSSGAYGGDKDRSGLEKPLAWFMAQLPNARSFDGPVFRPDDIMKLFGGLSLPGAGMPPAPPISRGPPPPPMQSRGYYEPERDRRYGGHGSGRY