lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MPQLRLILVGRTGTGKSATGNSILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPRTDPGCVETARCFVLSAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDSLQDYVHCTDNRALRDLVAECGGRVCALNNRATGSEREAQAEQLLGMVACLVREHGGAHYSNEVYELVQDTRCADPQDQVAKVAEIVAERMQRRTRLLAGLWGWRKFYWKGWRRGFSVFLGVAILIYLLFYRKGFGDQNNR
The following text describes a protein:
Function:
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (By similarity). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (By similarity).
Sequence:
AGVDPLVPLRQAMFNYFQVPDRLGILTHLYRIAEGAQQGDPLSRSWELLKEGFLLALTQGR
The following text describes a protein:
Function:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAFFSSGSRVLVEILTRMQSAERPMPVDHTFFESGSIRYHVEASASDPENVFLSISTPSLSYDYEEAAAAPSSSRLPELTLQEARKTYHRFAEMVEPPREGYVLTLKLNFSGLTRPKDRVKAINQVSLLQSVVLSSQLKHMLGSLGSSGTMRLVYNNQREPFFVSKTAEKINAIFPMRFRDDTDLAIATSFFQELQEVGNSFARAPKCSWSPIPPPELRGENVHHLTTNGGFVSFGVLSRHVRGKRPPRPRGSCSTSSPTSSTTSSAPGATSRAGCGSGWRP
The following text describes a protein:
Function:
This protein is able to complement bacterial recA mutations, but its native function in the plant is not known.
Sequence:
MRKLLASPFSSLLAVVFISVISVVRCCSPKDQTALNAFKSSLSEPNLGIFNTWSENTDCCKEWYGISCDPDSGRVTDISLRGESEDAIFQKAGRSGYMSGSIDPAVCDLTALTSLVLADWKGITGEIPPCITSLASLRILDLAGNKITGEIPAEIGKLSKLAVLNLAENQMSGEIPASLTSLIELKHLELTENGITGVIPADFGSLKMLSRVLLGRNELTGSIPESISGMERLADLDLSKNHIEGPIPEWMGNMKVLSLLNLDCNSLTGPIPGSLLSNSGLDVANLSRNALEGTIPDVFGSKTYLVSLDLSHNSLSGRIPDSLSSAKFVGHLDISHNKLCGRIPTGFPFDHLEATSFSDNQCLCGGPLTTSC
The following text describes a protein:
Function:
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Domain:
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Sequence:
MASGQGPGPPKVGCDESPSPSEQQVAQDTEEVFRSYVFYLHQQEQETQGAAAPANPEMDNLPLEPNSILGQVGRQLALIGDDINRRYDTEFQNLLEQLQPTAGNAYELFTKIASSLFKSGISWGRVVALLGFGYRLALYVYQRGLTGFLGQVTCFLADIILHHYIARWIAQRGGWVAALNFRRDPILTVMVIFGVVLLGQFVVHRFFRS
The following text describes a protein:
Function:
Transcriptional activator.
Subcellular Localization:
Nucleus.
Sequence:
MASDLGSSLTSIDWLPQLTIQASIKGSQQNSVGRKGPGSPADPSAMLSKEEAAAHRDGKPPYSYANLIQYAINSAPAKRMTLSEIYRWICDNFPYYRSAGVGWKNSIRHNLSLNKCFRKVPRPRDDPGKGSYWMIDSCPKEDITLPRRKRPHPDDEVSQDSFEQEVNKSPLSSASEVSMPQEATQGHPMNNNSPLPTYSQANPTQMPPDSRAPTYNNNDCYKFSFSESTFPDLSCSFRSLYHSLLGKQGERGDKDLYNSMQSKQVLPPVHSEVQSSSCCMYQQNSGAAPSNLHPHNVPSISGLPPSHHQAQHQQPPYLPQQQMPRPPAPGMSLGLPSDWCSNIDSLKESFKIVSSLDWSSVDLSQFSDLMESLRQAELKNWSLDQDHIASLCDSLSHLLSTTGLLPQNHGQPPSCQAPCMPPTTSSACALRGGKPGHNMAVNSYGQNQPPPVSCGHTFTVSSGYPTQSQAPPTYSQQGRHPHRALYPPQRPTLRYPQSSDDIQDDFDWDSIA
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MDSHVLAFPIPDPSTPPPEEASLYASKCDYYESDIYSQIRRLTEEKCIETEKELPVNIKLHVKHKGMSISSSRNELVVTVSGNYKNVYTAKIKILQAIPKILISKLVLEEPLENLLFDEDGYVYEDTMKHLDKITEITGAKIYIMHRSMCHDIDFQLRTDSGFSNRLNEQQSFYQRHLESTRHEFSCQKNAENSFFIVFYGDYCSVEHARIRVLALMDEIRGLSVVAIATSVSFQPILVGKAFSSTAGMKATESINIYTLPFCSDSIPRLQTLPALNSSKIIITGEEEKLQRLEEAFYYAEEHLKLFTHVTEISFVKLFEFLAYEMDELRLIMEENSSFIRFPEYFKEGGETSPENSKVKIYSSSIANSEKTALRLAKLASKYVQGKTQFGVEDNEDFLRVAGSWRRASTIEKGVSSSELSSIVSSTGSIVETNGIGEKMSFSPLKKLSIPPTEFVAQIAIICMASGVEMLLKTNGIEYFGQENTVPIAMDKASKIFYKFGQSQWHQILLEAPTKDQDFISGKKNGKLDKVKQQCRFNLKNGDILFCPQSTSIFTVDIYSDELERVIKGMNTMLLEFPAEMHFYVPEEIHKKLIGFRGEQIQRVTKLYNSYIEFSTTPFDCYGHNVLIRTPSKFSENLWAVRSLFIKTAEGLGYDIPKYLFAN
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MRRRPPQLTKTKLADEEVPELTLVPDGVSRWTGSDLDALLNAARRGGAEAAQQDLERKLCRTIDILGARSQQAQEINAVLTSVARLRENSTFRLYLLTQNHRGVGILKVGVKKLFVTHPVTCGLVEVDPLCVLDFYVDESCQRQGYGKMLYSHMLKAEHVSRPEVLAIDRPSNKLLGFLRKHYGLAAYTPQVNNFVVFHSFFDHTTVSERGKLLRAPSPARASPFPSSANATVAIGGAKAKNWTPG
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
MISETSAVAFRQNLGEMLNQVQYRHDSILIKKDGKPVAALVDARLFERIRRMQARFDALCQRIEAGYAQLPEAEGLAEIDATVAQVRAGR
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (By similarity). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (By similarity). Also has adenosine deaminase activity (By similarity). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages. Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface. The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity. Participates in pattern recognition receptor-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (By similarity). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (By similarity). Does not show laccase activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Endoplasmic reticulum. Peroxisome. Note=Upon stimulation of the pattern-recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum.
Sequence:
MAEAVLIDLSGLQLNAQKNCHETLLETLDGIHYHHAPKAKFLCIICCRNASKEKDGEYGLCELEAGNGFSRLAGKFETVSHPCLAASLYTIKQKIDEENLSCIKVIVPEHRKLLMKAYVGQLFTEVYEFEFEDLQGAWRDSLLKPSTGINVTTTQELEDIQHEIETYLRSLPALKGDLTIVTSPLIPDNFLHGFTTRTGGISSVPTLSSLNLFSSSKRRDPKVVVQENVRRLANAAGFNAEKFYRIKTDHASEVWVMGKKEPESYDGIVTNQRGVTITALGADCIPIVFADPVKKACGVAHSGWKGTLLGVAMATVNAMIAEYGCDVEDIIVVLGPSVGSCCFTLPKESAVSFHSLHPSCVRHFDSPRPYVDIRKATRILLERGGILPQNIQDQKEDLDLCTSCHPEKFFSHVRDGLNFGTQIGFISLRE
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane; Mediates sugar transport across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MTTFIIYFVSIVAFVFTIIQFFTGIPICLQIYRQGHVGDISGFPFLMGTLVLPFWLRYGFLRNDVMLISINCAGIPIAVFNAMFFLYFSKPKKYYMTQLSIVTIIILTMLMLIHFNPNVQFLGFVCIVLNLITFGSPLAGLRVVLRDREVITLPFVLCLVQLIVQCLWNLYGILIQDFFLVIPTAVGIMISLVQLSLFLIFPRKRDGYSPMAKVARCVFGSSNNRKEVPDEPQKIVVESNTVY
The following text describes a protein:
Function:
Together with NovH, involved in the formation of a beta-OH-Tyr intermediate in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Acts as a cytochrome P450-type monooxygenase with specificity for the tyrosyl-S-NovH acyl enzyme (L-Tyr-S-NovH) to form the beta-OH-Tyr intermediate (L-beta-OH-Tyr-S-NovH).
Sequence:
MSTRPTVSPSELEQIDLASPVLHAEYELDEIFRHLRADEPVYWQQPRNEQPGFWVISRHADVNEVYKDKEHFTTEHGNALATLLTGGDSASGAMLAVTDGVRHHQVRNVLSRGFSARMLDLIAHTLQETVDGLLLAALERGECDAAQDIAADVPLGAICDLLEIPHADRKYLLGLTSHAWSTDYADEPPEESWVAKNEILLYFSKLLKERRGGVREDMVSLLANCRIDGDPLKAAEQMANCYGLMIGGDETGRHAITGTILALIQNPDQWRALKNGDVDLNTATEEALRWTVPSLHGGRKATGDVVINGRRINAGDVVSVWISSANRDETVFDAPDEFNLARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYSSILHGMSSLPIRITG
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MRRSARVQALETIKRRKLSKLQAEGSHVTSHNTPDHVTQHPSPPTPADNATTVVGQNGQSGSSDGSHAQSTHVTTSGPNGHDPTPAGSNGHQVTTNLSATDALPPQQFRTTRAQAKLLSQQRNNFNAVLIPQTDLRPVNSHMTPKLDQFKFSQKAKVQSESENTVKIEDELESYDLSRDIKAEEKSAYFIKTEPVIPPLISDIEECHTFAAPQEFNVQDNPEVLSQPGPRGWSTIYARVKKMRALVNAPVDTMGCERLVQDGVPAKVQRFQLLISLMLSSQTKDEVTCQAVLNLREFLKSRDLLLSVDGILSMSVGEIDGCISKVGFHNRKADYISRATALLVKDFGGDIPPTIAAMTSLPGVGPKMAHLLMHRAWGVNEGIGVDVHVHRLANMWGWVKGKTPEESRVQLEKWLPQELWVDINPTLVGFGQTVCPSKGKKCGVCIVDKGLCKARLVKGLEWKEEKWMKEGYRKMMVEYEGVEQ
The following text describes a protein:
Function:
Acts as an anion channel mediating the transport of chloride, bromide, iodide, nitrate, sulfate, gluconate, thiocyanate, oxalate and bicarbonate ions (By similarity). Its permeability towards bicarbonate is weak and increases when pH is above 7 (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (By similarity). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function (By similarity).
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Lateral cell membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion.
Sequence:
MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIRVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFILIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVHKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAVVIGRFPRTMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNIIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEETSQSCPNEKCSLILDCSGFTFFDYSGVSMLVEVYMDSKGRSVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
The following text describes a protein:
Function:
Acts together with mto1 to promote nucleation of at least a subset of cytoplasmic microtubules, by recruiting the gamma-tubulin complex to the interphase microtubule organizing center (iMTOC) and to the equatorial MTOC (eMTOC) during anaphase. Does not appear to be required for cytoplasmic astral microtubule nucleation from the spindle pole body (SPB). Required to establish the eMTOC, and thereby to tether the cytokinetic actin ring.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes at the interphase MTOC (iMTOC) and at the equatorial MTOC (eMTOC) at the end of mitosis.
Sequence:
MSEHNYQSDREVAEDPFLNYEASANQLSSNSRESTPRGSPWRAGMRSASLMTEPLEDSMYSDNNYLDNGVSFTKDENPLYSPSWPSLADANVNSMKSNNAIQEHKAAKFVSEKSLEKVSTADNNLVLQELENLRERLNQVELQLSERPSSYLGYHNNLSPYRSPNSYPSLLPSTHSPHSPAPLSTMQTALMRLRTYHPSPIILKPVEQAVNHAITLVNTSPSSVVDALCRSLAELCLGLVQEAIDASILSQQESSNSLDLVRHTPPLNYTSSVDSSPQRMASDSYGRPSLHLNDPFPSVDLQSNELSHHNVRTTLFSDDSRFHSKIHTHSTPPSQMYSAASHFRYRSDPSTRHVSNSTNKSSLHPSPTSLRVAHPIIPQRASPASQSFPSLQDTPSP
The following text describes a protein:
Function:
Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the cell from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
Sequence:
MSLSQQSISIIKATVPVLQVHGVNITTTFYRNMFKANPQLLNIFNHSNQREGKQQNALANTVLQAAIHIDKLNELNLAPIVHKHVALGVLPEHYPIVGTNLLGAIKEVLQDAATDEILGAWGEAYGVIAQAFIDAEAALYKVTEEQIGGWRDTREFIVDRKVEESSNIISFYFKPADGKPIATYIPGQYITIKVPLTLENGEQRTHIRHYSLSDTPSEQYYRISVKKEDALKKSDPNGVVSNHLHANVKVGDKVLLSPPAGDYVVDQLSSNPILLVSGGVGITPLLSMAKATLAKQPEREVTFVHSSKNKQYQPFANELSQLEKSNKVKVSTVHSETDGQITKDKLEKFINPSQIKDTKVFICGPVSFMSAINKQLIELGYPKENISYEIFGPLTNV
The following text describes a protein:
Function:
ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Endosome, multivesicular body membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MSDNTRLLGHQKPSGYGTLPPCEFISCMEIRGYRRVTWKLLLFCILCVLTLGLLLLFIHWKPRLYVLLTCRHCPLAEAQWLVIKDAFGQISISEVRTEQGVDVSLGHHVIGRLGKNGVGSVIVGVEDQEEFKDTIQLHHKDENNELRYFVFEGMRYIWSNWTQNFVKVSSLDEGVTCGELHKKKLGLSQTEHNGRKQIYGANEIDVPVKSYGRLLIEEVLNPFYIFQVFSIVLWMCDNYYYYSGCILVISVISIGLSLYETRKQSVTLRNMVKMQVSVRVRRETGEEMLVNSPDLVPGDCIILPPEGILMPCDAALLSGECMVNESMLTGESVPEMKTPLTDGPQAGGTPYCPEEHKRHTLFGGTQIIQAKTYLDKEVIAVVTRTGFCTVKGNLISSILHPKPVSFKFYRDAAKFVLVLGLFAFLGNIYSIGILIKNKVSVRRIIIQTLDLITIIVPPALPAAMTVGTIYAQSRLKKQGIFCISPPRINVCGKIKLFCFDKTGTLTEEGLDVWGVVPLDNTNFLPITHDPRCLPDGPILQSLVSCHSVTLLKGNLIGDIMDVKMMESTNWTLDSQDMDEQMTEHFGTKVLAVMKPPPLDEQPHGPKHHVPIGVLRRFPFSSALQRMSVISKLPGDSPALLYMKGAPEMVASLCKSDTVPLDFSAMLKQYTKDGYRVLGFGYKTLDSVKTFEDAQLVTRESVEQDLSFLGFLIMKNVLKPETAPVIHELRRANIRTVMVTGDNMLTAVNVARSCHIVEATERVFFASASPPSLNKAASVKFIPAEAATPEETQETLYQQGGSFLDKGPYCFAMNGKSFSALCDHFPQLLPKILIHSAIFARMSPDQKTQLVQNLQELNYCVGMCGDGANDCGALKAADVGVSLSDAEASVASPFTSRTSNIECVPALIREGRCSLETSFGMFKYMALYSLTQFITALILYTVNTNLGDLQFLYFDLVITTLVAILMGRTGPANELGIKRPLGTLISLPVLGSLIFQTILILIIQLIPLFLVQNQSWFVPVNVTNPETVHLPNDENTVLFCISGFQYLILAVVLSKGHPFRKPIYTNVPFLLLLLALLALCLWITIAPLGFMKSLLQLVTYTDINFQGVLVGLVTVNFIAAFLVEMALDYGFLNCLKRLRRKKEPKKLYKRIERELQGQLSWPPIEQTLHPGPIQTYRGR
The following text describes a protein:
Function:
Does not bind lactose, and may not bind carbohydrates.
Sequence:
MSEKENNRNEEDYVGEIKGGLRPTMRLIVMGIVHKQPKSMVVIVSCQSKGEGDEEIEGDVGLELKVNFPEKAVLRNARLSGKWGSSETALSFFPFAPGEAFKMEIVCEHQQFRILVDGQPLCGFAHRQTQLASLNALRVHGDLQLTKVA
The following text describes a protein:
Function:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
Sequence:
MALAPERAAPRVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSGDPADPHKVYALSRELCWREGPGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPAPAGDKGDLLLQAVQQSCLADHLLTASWGADPVPTKAPGEGQEGLPLTGACAGGPGLPAGELYGWAVETTPSPGPQPAALTTGEAAAPESPHQAEPYLSPSPSACTAVQEPSPGALDVTIMYKGRTVLQKVVGHPSCTFLYGPPDPAVRATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRMGKCKVYWEVGGPPGSASPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIYLGFGQDLSAGRPKEKSLVLVKLEPWLCRVHLEGTQREGVSSLDSSSLSLCLSSANSLYDDIECFLMELEQPA
The following text describes a protein:
Function:
Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway. Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MTGRILTVENISALEGTSATLQCHLLYTAAEITQVSWKRNGHLLALHDSIYGSVIDPAFRKKVTLAPAYGITLLSLNASDTGEYLCDFYTFPDGIYKGKIFLEVTLPSLPEDSEADALDSSHSRISFGIMVSVIIISAATVIMLVILGAMRKTFRINSANCHQMGRSPSKQNELRSASLGSCLPTEAIPMTINQIYELENGIEESRTYFNIIGYRSLNSFNFSVETRVPTNEKHKIDS
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSELDGINQHFEELRKRLLRIVLVIGVITAFILTFHAEPIQVGQTTLYYPTPEPLNNIAAQITNHMKVNLVPEDVQLIQTAPGQAFFAQVYIAALVGIVVGMPVIIKELVGFIKPALKENEINVSRSITIPALGLFITGCAFSYNLVIPYILEFLYRYGESAGLVTFLNVIEFVTFVLQFLLAFGFSFQLPLVMYAISASGMVDADFWRKNIRYAIVIIVIFGAIITPDGSGVTMWFIAGPMIALYVTGMMLIERKERKKLNT
The following text describes a protein:
Function:
Protein-histidine N-methyltransferase that mediates methylation of target protein on His residues.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQANGFSFGFYDEPNNLNGQDVGADSLPSVAIESDSLGHMLKYIPEKLSYARVSGLGHTFVQRELWDVKMQLMEQDDSIESDDKLKVLDGCNDLVPNVYEGGYKTWECSLDLANEIKKIDVVKNNLTTVLELGCGSAIPILSCFQEFYKHRIPCTLVFQDFNVDVLRYVTLPNLLLNWYFCTQEHDSSEKHGTIDVSPSLLQEFSDDLARTNIYCEFLCGCWSEEMQLLIQRTYGDHYFSLVLASETIYSLPSLENFLYMLLKNTKNLALVAGKDLYFGVGGSILEFNSRLQKLVDDPNSLKAIKTSTQNVGRSIVYWEKEFPPSNIDSSPQSPLPGSL
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLFYKLICLFLSFIIIIIHGKDISSTKKLLKSGNLNNKIKKGRERYGGIYNSKYMTIEKRRKYNYIKKQKNNNNSYFSYCNVYKNNDVNNNYTAYNYYINNPKNKLKEYYEKIKNHVIKKKKKIFSLKFSQNKRNEKKKKYFFINFTSFHDIKDNIKVLFNIDYIENNIIYSYIKSFKRTPPITKIYLLGTFLLSVLIHMNKNVYKLILFDFNKIFKKGEIWRLFTPYLYIGNLYLQYILMFNYLNIYMSSVEISHYKKPEDFLIFLTFGYISNLLFTIWANMYNENIMNVKLYIHNFKNFFIKDCVSKYTSRSSTNNNSNNINSNNRSSNNNNHYNNSKNIDIKKEQYNHLGYVFSTYILYYWSRINEGTLINCFELFFIKAEYVPFFFIIQNILLYNEFSLYEVASIFSSYLFFTYEKYFKFNYLRLFFKTLLKVIHIYPLYDRYKEEYE
The following text describes a protein:
Function:
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLRAGARQLLAPGLRRLGLGTGAAGQVGPAAAAAGMRAYHERVVDHYNNPRNVGSFDKEDPNVGTGLVGAPACGDVMKLQIRVDEDSGKIVDACFKTFGCGSAIASSSVATEWVKGKPMDEVLTIKNTEIAKHLSLPPVKLHCSMLAEDAIKAAVKDYEAKKAKMGQKSEDSPSEKAAEA
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MKDLDWNNLGFSYIKTDYRFIAHWKDGKWDEGKLTTDSTLHIHEGSTALHYGQQCFEGLKAYRCKDGSINLFRPQANAERMQRTADRLLMPRVPTELFVRACKEVVKANQDWLGPYGSGATLYLRPFLIGVGENIGVKTAPEFIFSVFCCPVGAYFKGGLAPSNFITTDYDRAAPMGTGGVKVGGNYAASLLPHELAAEQGTPERKFADAIYLDPKTHTKIEEVGAANFFGITKDNKFITPKSESILPSITKYSLLHIAKERLGMEAIEGDVYIDQLDQFVEAGACGTAAVITPVGGIQHNGKFHVFDSETEVGPVTRRLYDELTGIQFGDIEAPEGWIVKVE