lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.
Miscellaneous:
MISCELLANEOUS: Present with 4460 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Sequence:
MTESVGGNKLVDFLVNVQSILNAASVKCHVVDESFPAKFFEKNPDKIYESYCKFIKNRSNSEGLIRNEDKLVLTTINKRFENGEYEPIQGGFYKLYHDIKLVCTILIHFYPQGTRNYQLVDKFYKFSSELLLRECCRIGIALTQTNNIKSRSGKLLSGNEMDEYDDDDATELDKIISYDFIKISMNYTVPISQTYQIRTKDMDLFSSIISKSNLDKRPHELPNTNFKINNVLPQTDIENEAPRLGFVGANTSNIPDPTLPPTEMMTRFLHPNWYALPTTVWLKYGNYNSWAPSFNENGTVVDSTTRGLIWLERIGYMDLYEKNEKKVKQEELLNTNEEGINRKQNDENNKNVDGKSNGVQDDGGDNDNDATIASANSESTENKEQFIIKLQNLYNWTPSNYIGDDEIENFRNGTPDKLVSDSLLKLKRLRKERILNKVLKPTTEERELYFKVKRILKEVILAKKVSKVPINNVRAFPVLQTNYNGSIPVVRAQPGRKRKHKK
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MMEVKAAELVAALKNSNMSVDTKVAHLQCVKSDIKQKNVPEGAVPSIFESIRLAIASQHSSLSGAGFSTLGHFLKRLLIQELHHLVALQCRALYPLLVERLGDHKERIRAQAAQSFTDMWLAAPEEVEQCVLGQALVGKNPRAKEMSMIWLSNVSSSFNIGGFSSFLTIALQMTKNYGLLFRSYVSSLVACLEDADSNVRNTAKNTVIELFENASERAKSDLKRQMATHNVRKSFVNAILASIDHGTSDMDAASRPISRAEALVHRPVSRAETQASRSVSRLDTHQRPASRMELAQSSVLHTEALPPRPVSVLSSRSETHKEVTKEVIGVERPKSRLTTAKSEPNWAVVSHTGPAEELPLPSSRPASQEGEKIDALYVSSSRQVDELFRDMMPHFEGRESEDNWIRREKDVLTLRRLTHGNAPDDYSPAYLAGLKTLLDGIFKVVNSLRTTLSTIGCLLIQDIAKRCGPRIDSMVEIMMQNLIKLCSGMKKISAQNGNATVDALIENVTFTTRILQHVSGACQDKNVQLRLFAAGWLKTLIQKQSHHKSSIEHGGGLDMMEKSVKKCLADANPGVREAMRSTFWTYYRVWPNRANEILSNLDPKSRSLLEKDPANPNAHQSAPKDSGPSRKGLANGTSSLAGRSALKEAIAAQKKARLAPAKAVPPPRPESAQSALSDKHSSAPSSSKSSVRTVPTGTSLSSLSSAPVRPAAKPRRPELNRPATADPYAARRSVATDSSTRHGNQIDGSPSAAKSKSSTPSLKSVSSTGSRDRADPVGTTRDRPKRLVISKTRSHDTHTRQHSKPIPTHSRKNSNESIPRHSPLRSEFSVTPISPNSVSLETPSTPRSHLVQDHGNLIAIASPPTHIQRTPIEPDASAEDPREHAAKATPVAIFEDTTPARSDHDDIQDAAMTLTENQTPQPSKVHSDSPIVSNKRVSNQDESVPHLTTGLGFLTGVGSVVEASELPNSDAQTDQSLFADHSLPVTHQPDSVTDSSKPSGLSSSLMVAGSPIRVANNENEIVIDSKTTHVSLPHRSSPKHNVLGELTSNEPSQRANKQIRHAANKLEDEVTTPIDDHSRHRWKKVEIADRRTSISPRSKDPTKAQQMLDKGIQRIRTKTMDILGYRKLQGIIKYHDSIFTNEEKYDEMLLALLDELESSPDDKRQPLGRPLDLKTQVLLTIRLMLIHNKIYFSAYCSRALGALVLARKYYDANCHIVSGLEETADDIIALCEPAAVIDSVLDVIITEEKDDREYRSILMGVSVLTRILSRLNADKCRVPELPLDRLGQFAASKLADRQPDVRRLAVQLCVQLHGMVANEEEYWRVLGHPRENSRNLLTYYILKK
The following text describes a protein:
Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Sequence:
MVKSSLQRILNSHCFAREKEGDKPSTTVHVSRAMPVLSLHSSGSRSSESSRVSFNCCSNLGPGPQWCSDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLTVTEELTSNNRTRILNVQSRLTDAKHVNWRAVLNNNSLYIEIPGGALPEGSKDSFAVLLEFAEEQLHVDHVFICFHKNRDDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERDSSEED
The following text describes a protein:
Function:
Acts as a receptor for A-type allatostatin neuropeptide hormones.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MESTEDEFYTICLNLTAEDPSFGNCNYTTDFENGELLEKVVSRVVPIFFGFIGIVGLVGNALVVLVVAANPGMRSTTNLLIINLAVADLLFVIFCVPFTATDYVMPRWPFGDWWCKVVQYFIVVTAHASVYTLVLMSLDRFMAVVHPIASMSIRTEKNALLAIACIWVVILTTAIPVGICHGEREYSYFNRNHSSCVFLEERGYSKLGFQMSFFLSSYVIPLALISVLYMCMLTRLWKSAPGGRVSAESRRGRKKVTRMVVVVVVVFAVCWCPIQIILLVKALNKYHITYFTVTAQIVSHVLAYMNSCVNPVLYAFLSENFRVAFRKVMYCPPPYNDGFSGRPQATKTTRTGNGNSCHDIV
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSADKPEQPEHDQEMPLVSHLTELRTRLLRSVAAIFLIFAGLFYFSQKIYTLVSEPLRRFLPEGTSMIATDVASPFLAPFKLTMVVALFLAMPVILAQVWGFIAPGLYKHEKRVALPLLVSSIILFYAGMAFAYFLVFPMIFHFFASVTPEGVAMMTDINSYLDFVLTLFFAFGVAFEIPVATVLLIWIGVVDVDYLKKIRPYVIIGCFVVGMVLTPPDIFSQTMLAVPMWLLFEIGLLFGRLVRKRGEHPDDQPASDGDQPPATRQ
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MFGQGARGLEGWGHADYAADKEITRLLEEIPRATSAPPHLADRWAVNPDSGVDPNARATPVGQHLGDIRFDEDYARFYEMYSGQRKLPPPVADRTLYQEVPGLFPSRLQQQLGAVGQAQAQILSRGVTPGLEVIDEQGPTNDMAALHEGMMQAFQQLGVRGPSPMPGHLNGVSPHGSKPGTPSPLDVAAAAAAAAAASAPNPLLLQHGLGSGLESMLPPGHGGMNGLHHHHLGGGGPGGMPGNNPLAAAAAAAAANSPLHPLTNSLEYQAAYQAAYQAALLQTQQQLLLGQQAGVNPLTGQFMPGGGFFAGNASAAAAAAAAAAAAAAAAAAAAGPGGGLGGPGLQGMRLGGPGHGGPDMDGGMGGGMGGPKGMMRGGRDGPGGRDHRDGHHRGGPGGPGGRDGRGPSYDGRGGRDGRDRDGRDRDGHGRDGHGRDRRDGHHRDRDHHRSGDRHGDRHDRHHGGGGGGHSSGGAGGDRHDRDHRDRDHEHEGMAAIAQKYASLDDVVGQLMTVAQDQNGCRYLQRKFDEGGAAAVEKVFPEVLDNIVELMVDPFGNYLVQKLLDRCSEQQRLEVLKRVAERGELVSVALNTHGTRAVQKLIETLSSREQRAIAIEALRPGVVSLIKDLNGNHVVQRCLQRLGPEDSQFIYDAAVACCVEVATHRHGCCVLQRCIDFATPGQKQALVMEVARHALVLSQDAFGNYVVQYVLELGHLDSCAAVVVALRGSFCSLSLQKFSSNVVERCLKLGGLDAERELIVRELIQPNNLSRLLQDGYGNYVIQSALSVTSGTTHGLLVEAIKPYLPTLRGTPHGKRIVQRINGKV
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MASDVKVLLQRFEHWAHRLYPKFPFENVIEQVESLGKKKLVQASDVKVLLQRFEHWAHRLYPKFPFENVIEQVESLGKKKLVQSVHTAPDTTAAAKEAPVELTADQLERIRQNRLKAIERRKAIQVSKAENQPMETETRPELIATEGTGIIREDAEGLPKEIEVSPKVTKVSPKQIETSPKEAEVLSKENEISMEETEVSPEETGVSQTKNGISQIEAEVQEKEIYFPSKAIEILAKEVEPLLVEVQLPPKATEQPEITPD
The following text describes a protein:
Function:
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Subcellular Localization:
Cytoplasm. Peroxisome membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MAAAEEDCSVGAEADRELEELLESALDDFDKAKPSPAPPSTTTAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMTSQQEFTSCLKETLSGLAKNATDLQNSSMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGASGEQCLIM
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MHLLGKHTMEDAVTVKCPPEISHEERKESPPRGPKTATQDEKVKKSVVNGSSKQKELVGGNDLKLVMEPQNPSPTKYFDTNGVPLRKAVEEGNLGQTADREGLDKKPSKVTIKCCNCEKTFTSRAAYELHYRTNYQQEPVYECPVCDKRIKQYRAYQLHSYRHSANQRFTCPECSKTFHQKSDLTRHQNIHQPPGSNGSGTSKERGAAKNGGDGNEQVIPCPRCDATFGTQAEFKEHSRKLHRTPKQLVECPDCGKLLSTGSLYSHRKIHSESPKFSCPECDRTFVQKINLIHHHKTHLTERPFQCGQCDKAFCEKAHLQRHLNYHSQERPYRCELCGKCYKTERCLKVHSAVHNNERPFVCTECNKGFLSSSKLRQHSNIHSGLRPFKCKYCTRDFTNFPNWLKHIRRRHKVDHRTGEKLDSVPKFMTKKKLPVDRGVRKKEQPPVPPEASVTAGGAGEKGKKRAAVKQRPIIPLPDVLKDESLPYFSESSNIDLNLVCKEDLLQPLADEMEDIFQCLPSDESKLSIPEPLEQLSGGTNAVDVPLNGGSLLQPEVDCDFSVRSPMADQSSVCNDLITQELPSNALSSCEEETFSGTLLYDAHLPILPAMVSFCSNSSEEQQFRLINPHFIHLTNPAPFLAGSSKLPSDSGTVPVSIGE
The following text describes a protein:
Function:
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MGDRRRGGPYKTEPVTDLTRWRLSNVGGRQTWRYYGEGETPEREQNMVERHALGLDTSAFAPALPKAQTAREAVRNGMKFYSKLQTEDGHWAGDYGGPLFLMPGLVIVCHVTKARLSEPQRLEMIRYLRSVQLPDGGWGLHIEDHSTVFGTALNYVTLRLLGVPADDKDVVRARNCLHAKGGAVGIPSWGKFWLAVLGVYSWDGLNSLFPEMWLLPSWTPAHPSTLWCHCRQVYLPMSYCYAVQLTAEVDSLVRELRTELYLEDYERINWPAQRNNVSACDVYTPHSWLLNLAYVGINLYESWHSSSLRQWAIDELYDHIKADDSFTKCISIGPISKVIQMLVRWHADGPTSPAFREHASRVADYLWLGLDGMKMQGTNGSQLWDAAFVVQAFLEAEAEKEKEFTSCLHRAHDFLRFSQIPDNPPDYETYYRQMNKGGFPFSTRDCGWIVTDCTAEGLKSMMMLQERCQGVQDPAPDHRLFDAVDVLLNMRNSDGGFATYETKRGGKLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFQDQYPDHRAEEISDTLKKGLDYVMGLQRSDGSWEGSWGVCFTYGTWFGLEAMACMGHRYDIGTATEAVTRACNFLKSHQMKAEAGGGWGENFESCEERKYVQSDTSQVVNTCWALLGLMAVRYPDLSVLEPGVKFLMERQMENGDWPQENICGVFNKSCAISYTSYRNVFTIWALGRFCRLYPHSALTGGAAKS
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Sequence:
MLIAIWAMTQEGLIGNNNTLPWMIKQELAHFKKTTLFQALLMGRKTYESLPKVFEKRTIFLLSKDQNYRFEEKGSEVKVINDFWPLIKSYQANKEKDLFICGGKSVYEQTINECDQLIVSIIKKKYKGDQFLKVDLSKFVLNEVVEFEEFNVNYYRKKQQ
The following text describes a protein:
Function:
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component (Probable).
Sequence:
MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSAQEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSMSDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDSSYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAAPAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDSLGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQAAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPARLYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQNFKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEWQNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAHDVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY
The following text describes a protein:
Function:
Required for normal synthesis of the cell wall.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MYALVIFNIVLCNALDVNFNSSASICNATKLIQQGILDYYEGLRPGGRVGFFQEPYYWWMAGDVFGGMVENWYLCDNTEYKDLLTEAMVSQIGENKDYVPWHQRMVEGNDDQGIWGLLVMDAAERDFPDAPPDQAPGWLALAQAVFNTMWARWDMDNCAGGLLWQIYPWNVGYDYKNTISNGYLFQIAARLARFTGNSTYGRVAETVFDWLVDSKLVQLDNVALVLDGAHVYTNCTDFTRYEWTYNYGVVLGGCAYMYNFTNGSPVWANRLNRVLNGALLFFENGIMYERTCQDVDRCNNDQRFFKSIFTRMLALTSVLAPHTKARIEPNIRKSAEAAAKSCNGGSDGHTCGLVWRNYTWDGKAGLGEQLCALEIIQNTLIHTKRPPLTAKQGAKSKGDPAAGLNSSRYDLPIVHPPSGQKSSILTTLRSLSSSAKVHRHYASTSTRVVQ
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
MDELDSSFEGSYAHEDLKKRLLNNDLYAIKDVIVPKLRKDEYKGCSGKICVIGGSEVYSGAVYLSSISTLKIGGDLCFVITTDENKYPLKSYSCELIVYPYLYTKKSDIKEIENSPLDKCIKYLLERIDSCVVGPGLGEIDEFTEECLIYILEKFLEKNIFLILDADIIQVIMTNMKIFNLIKNYKNCLLTPNINELRKMLTHLNNNIINEDVKNIDFKHLTVYKIIQYAHALKSVLNAPKILIKGFHDVYISDHFFFVFFMKRQCLKRSGGFGDILTGIVSVFLCWASKIIKQGIELKDIISTKETFLSESFKDTVYTNTHVQNNDLLQTVAIFNASYFLKYLCKKCFRKNHRGLLASDVVNSIPPNFYRIYDLKKKIKNNKIKNNIIKK
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSASYWDSSQRNKWQYSRESLARTRQKLWMLECQLYPQGTNILMEGGGKDAQPVTKNIPITHRDLHYDRDYNLRIYCYFLIMKLGRRLNVRQYALATAHVYLARFCLKASIREVNLYLLVTTCIYLACKVEECPQHIRTLVNEARSLWPEFVPPDPTKVTEFEFYLIEELQSYMIVHYPYRAMEQIAAALRRPPYNLVLSPDDLQNSWSLINDSYITDVHLLYPPHVIAMACLFITVCLRSAAGARDLQETFNRFMADSQVDLHEVMDTIQDFITLYDHWDKYNEPWIKFLLHNLYLRPHAGGTTVSGAAAGSAGPAGSVLTPNGTITGSTS
The following text describes a protein:
Function:
t-SNARE that functions in transport from the endosome to the late Golgi and on the endocytic pathway.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Endosome membrane; Single-pass type IV membrane protein.
Sequence:
MAYRDRTGLYITFRQSYSHHGQRLELSGWDPKEERQSLVHKDNKDNTVIEMDMLAPRWVTVEGEIDSLLLNTRRNINLLDKQYAKHVLPSFSDKTEQENEIQRLTIQITQDFQRCQKLLQVTKAQTNSATGSEALMAKNFLSNLASRIQTESAQFRKKQSTYLKKLRGLNANISPVESKLDETVSDVAISQSTIQQVALMEEQGEDEQAIRHERAVAKIAEGIIELAQMFQDLQVLVIEQGALVDRIDFNIEQTQVHAKSAEKELIKAESHQKNTGRLRFICFLILLIVALIVILAIKLLR
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MPRHPLAPTPFDDLRTDTTSSQVSTEIDISTILLSWLDSKDDGNPSGSQSVDSVLLTRSSHISFLYPSFSKLPIRNTALDSSRGWIIYWIVGAFSVLEARLKQVERLKAIETIMSCQHPQGGFGGGPGQLAHLASTYASIAALAILLDGADQNIVDKTCSQIDRQKMLQWMLSLKMPDGSFRMHHGGEIDVRSCFGALTVATLLNLLTPELVQDLPEYIVSCQTYEGGLCATSLSNGCVRPQGNQLDFPSAAPVGEAHGGYNSCALACDFLLQGLPSLSGSPRLDYDSCLRWAAQMQGLPIEGGGFRGRTNKLVDGCYSWWCAGAFPLLQALMSEDFSDQHESFDLFDRQALQEYILLISQDLSPKAKQGGLRDKPSAVPDMYHTHYILAGLSLAQHSQKHSLQRIEELKQAFKKPDFSTCILGNSETESDALERMKIIYSRALAWEVQKDKDLVVGMVSNEVLPVHPVLNIKHLAVEKMMNHFYHQR
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation and is required for bir1 localization.
Subcellular Localization:
Nucleus.
Sequence:
MEWDADDLLIEPTTEVENDYEDLCTQWVNERMAPDLLPFAEEIVSRVLDRIEAQRETLQLAIGTSSATSYRSVLMQTELERVKFVLRSYMRTRINKIDKYAQYIQSHPNLLLYLSSPERQYLLRHQQIVHRHYMDSFLREVPAKMNKLDDKVGNLSMVASPDMDTAVFCVVNESVEENFRVSENEYITLDKGDVLILRYSVISDYLRLGVVSLI
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Sequence:
MNDINNNNVNNNNNKNHINYNIDVIRSNFIILKSLAESIKPSFGPNGISKIIVDDKSKSYLLYGGVSTSLLLSSSLMENALNLLYKGLDLNSIISGYKISLNYSLKYLNEMKSIKLDIKLNEDNNLNKDNLLNIFNIIVQEKGTELNNNDYLVLKDILSDSLISQNHSKKSIETKLNNINISIDQIYQYSDFEINNNETLSKFGFKNYTNNQISTTTTSKILLIENGLIVDKNYCCSYLNEIKEEGNNINILFLDCSLSRDQSNMQIQVELDSPEKLLNWKIDEENYFKQLITTIINELHVNTIICTGDIDPLALHYIDQFKILAFKFVPYLIFKKLSLSTEIIYHLNLDSILQNKNKIVSKHYEKIILNPLQTILCESRNYYFKLNPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNNNNRDDAEIEIQKTIIILSETYFQSQELKRYCQDLLMGLKLLNNNNNNTLNFNENENENKEISNKYYILGGGEVEKVIVKSLLDMSQQESSILKYSIESFSNSFQSLLCILKLAKPTELSQKQLISPIIYDNYFLKKKQIIDSTNLVLTLLKVD
The following text describes a protein:
Function:
Catalyzes the hydrolysis of melibiose and alpha-galactosides of the raffinose family of oligosaccharides (RFOs) such as raffinose and stachyose. Cannot act on polymeric substrates such as locust bean gum.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRYGLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRYTNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIKRRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLDEYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTGLITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKEAVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MKCSLRLFEKAGRLSVRSQTVQTFQQRIVLANGASYLVNTTLPKPYILSIKDITNMPLNNPKVNALSSIRGQESRRSKFEERYEGL
The following text describes a protein:
Function:
Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Cubn.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGLHWQWLIWALVGLHVALATKWYGGGMDFNDPTAWLDDHLPCAQDLVVFPEYYPALLPLPEDISIDGLVFPREGAILLAEESTITFGSDKQPSCESDENKAYLKPPKSSKWFDPGTWTDKSKEFSTFTPELERIPCDDEQVIIKGHGPLAFDLENVQYLRLGQLILAGSSISKTYLEQLISRDLGQFLFYNAEYVQVEYYRGELCGCHKDFERLLEPVCHNVQEQCETPHCLSPVRPLGSCCLICGAILSTPTTHCTEGSRKELVAQISNLISQESLKDQIGLHVEFVGSQKFGNCLQAVVTDRHKYSERSLEFLQQNEHNWNKTGTTLKVSGRPYNPNVSFSSIVLILFCMALVGLVSVVILAHFMPENPYLNRIPQWIHDPRLWRWRHLGLRLRRNLLFNRFDNGGAEGGSSEGGASGVDRLGIMAYDPESGEVRERAFDNPMFEQGGALEEAAKESQEQDEILSVPKMETGDLDARSVVDEQELTEINLETCEADTDEETI
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTSPLASQLQRLQQRPDGSQHRLAKSFLFSTQDAQSFSREQIHQLALNGLQALTAIDNRFHPFIQDLFDVKRVRQERSMLTTTEDSTLRVRLEQFLTFLSPHLFLTAAQQVFEFLVRVYEVHIYDVASVLRAFLPYHDHNIFARALLLLDLRDTGFDFLATNQLHGAPLLREHLVLACAESRKAVRLVCLTVAMPFRYEIRHHAANALFASVVTQLTTHKDAEALWRTFLPFVLELLSGAVSGAEAGTEESKRARQSDNARGGSSRVSMESVATALVVLAAWSAHVRFSKAMLITMLKPIFRYTTAAAFAATSEGHHGAGVSYLPVRDLLALLEIVLATQHHALSDVSVAPLLQTLLTLPWRTLASQLPFAEMTVMMAGPNGAPTASPRHSALLATLLQTALERLSSVSEARLLPSDVVEFLTCAAEDLPLSNYMVTRYLRVLMTAEAGTSPAGAVGDTPARAAEGASNQSLYYRLAAALERRYAIVFDGVLSEVLLHPETTAAATAFLARHFRGTRYGMVEVGSALSGATETLPLFACLLHPVAEVRALAAKTLQGMPTAQLISDASTASGSGQSLVDLLAHVISYERNCTAAEAFVATAAAVIERLAARWSSEKSMGRDELGCRAACQLVRSVYSMVLAWSPSVASAASASVATRVEAQRRVVLPLVTTLLRPALLTWTRGASAVTSDAQDFRTSVLYHATLLYAQWAGTPSAAMQTPGEDVAMATQVVGGLVATLEAGCGGPDAVALLFRARSASNKKQGKKTVRNGSSGEKERQRVGRRCIAAAESDSDDKEQQQSQAGSSGRSGCIATGTRIACFTDLIQCDALLDAIRTEAQRRLPDAFAAARTAVREGATDLSSAAACEVEVAVALAAAVLPAIGTEKPANVLETVSAVMTFLHGGDAANDAAASETAMASSATSAAADRGYLDMVYATLLDNSSGRRVAQAGRGTVDVSTAAREQLYEVPLVARVGAVLRAALTRVLARAATAAAASVSSLTSLVLQLCQGLGFVGAALPSIAAQPDVLAPAYLELISSMNAVTTTAEATSGAAAALRQVDWYALVADAVFSAAGQSEVNDAPYAKPMTLAALALVLFLPLRAPSTQRLAQLRALQDAVVTAGAQHDSACGGANGRTGEQVILAAAMQLQQGTSSSTSSSACSVTALSCLIECMAVEERQYQLTPSAAALVCSLLNMKNGTDGGAQAYVVPVGWAHRVVRYFFRSHNSHGGGRARAGSSAAAALLPAEITPQQVCLIEAMLPRVEGILTSIESVDASSSSSTRTVTADAADLVDAVCSRLQLWGSASAKEDAVANNASVRLVELLLKHPYVHVHHGGGARPVYRYALAALVVGLSYGLEDRQSTQSTIFKSRKSASTAASRKGEYALSAEYQRLVAARLQPVVLHAIDVIGTDVALACMGTLGGYEYFFLPLVATVESATASAAGHPPVTSKAKAARGRPSQAMSTDRETASEAVAVLLKRVHEMLETLAPSTAAAADETLSAKHNGVTELAAEGEDCAASALEARWRPPASAAVANPLTFADARRVLRLPSVCAAAAGGTGKWPLGALSHESLRLLRTLLRVLPTIAMDEEEDGESVFALVIECVELYPLQGMEVLLRHAASSAASDEVAMLPRVKQLRLGARGSLQVEGVLRFVETLVHVCTDQTQLLSEKVTDGAHRIKSLLLREMMVLMARILVDDRSEDNSAEKDEEASAASPRRAEADTEAAERRQGELHFHVDTIAGLLRATAPLLKAPTAAAAAAVTARSSMAESSTYLHIPLVSLLIKLEPFDNTEALGFRSARDVCQEILSNFDVRTQVECLGQLMRLVADPAAQLSSGANAGEDGEEQQRLQHLFRRMVKPNQVTNRQEAIMHLVNLTVKSDLFLEPFLALQRHARSSQPSRAAERRRQQQQQQRSERSTGADKADEKASDADEEAEEQAEGAVQREDGGCMGLLVSALELFARYHDLHETTRSGAASESADAEAEAYTSLLELLAGNTLACVLAGINEPTFVVCQQRLLEDERAALRKIGLEVLLDRLHHSLPTLENVVSDEEMEAHRRRLRDPRQRLSLADLVRIKARPLTTKRSIQLFPLLVAEIKSSVAQFHAAAQSANAAGELLTTAQLGIAAVEELIRIVSSGGSLQSEKTLLNANRSKRVTEAALVKLFGNRSRVAAVHELVDLICNHWMPLLTRCEMRLRSRAEQPGTDGGAYDSTAASRSGAEENVLGCMTCLVTALATITQVMGTAFASTHCLHLLHTLVSAGVYQVLEMPGVVSRSEAGALLRHSTLSSMIRCFPACWQMAQPYLPSMLFLVTHLRNVTDAESHYLSAEMLAVLEAVMEPQLLLDAGITCLQGLPYLNGAVVPASEQHQLANLAAEAAASASEPGKAKKGTVRVRQIRAQVHTHSFALLFTCFERRVENMSKEELLHMRTLTEGTTPQQNFWLAAFQSLASAPSAPSSEAVMPVLQAFTVFLLKFKAKHSVRLLRIVADWAFAESSGGVAGASRKHAAGPGDSANTAAEEEQNGRGHDGAAQSISRVTLQSWIVFFALSNHLLGKLGSILDFAFPIFLPHVVTALRTYCAATATASKAMDSLVALALEGALECMRNMALAQTPGPDHDYSIQVDVYFAKADVFPGVMPALVHQLHNLHYLEDSQRDYRFRVEHNVIPAIRAFMACLGSSKLQSRTQAEVVRALRHPSRHVRREALICLDGIYADGGDELASRLMAEMLPTVVELTEDRDDAVVEEARKLCNNLSHMTGQDVLYAMS
The following text describes a protein:
Function:
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDARDKQLLRSLRLELCTEVLVDGLVIQYLYQEGILTDSHVQEIKSQTTSQRKTMMLLDILPTRGPKAFDAFLDSLQEFPWVKDKLKVKRKEMTVQDPAGLKQFLSCKLTALSVVLDIILSNTGVLEGIGGLLLHGAVMPLNLQRHDGKFTQLHYSDATEIAPCILKSSPTDQQMNKLARRLGPEWEHIVLCLGLSHTDIYRCKVNHPHNVQSQIVAAFVLWRQRFGKSATIQSLQASLMAEEVDPSVMRYMLE
The following text describes a protein:
Function:
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.
Sequence:
MIESKRQKLDEEERKITVIAHPNIALIKYWGKASEAEMIPLNDSISLAVNYFHAKTTLIARKVEKGEEIGDTVSINGKDVGLNSRFHRVFKSVRDKLDCQWSFTVSSSTNFPVAAGLASSAAGFAAIAFALGKTFDLPEHDIVRLARYGSGSASRSVLSGLVQWKKGNDKTESHVVSHFSADHWPELRLVIIVVKDEEKALSSKEGMERTAKTSELLQDRIRRNQERINLIISAFSSHDFPSLAELIMRDSNEMHAVCLDSYPPIQYLNATSWSIINFVHSFNKESVRAAYTFDAGPNACIFTLKEHVNELYDRVTSTFSKGKEVKDVYISELGQGPQIDN