lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCPTGGSCSCAGSCTCKACRCTSCKKSCCSCCPAGCARCAQGCICKGASDKCSCCA
The following text describes a protein:
Function:
Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMSSNLIMELSTMIPTHSEMLQNHSDQPSGNSTSHNSTNDAFDEFVRCLTLFTCICGVIGNGIVLWLLSFHIKRTPFSFYVLSLAASDFTYLFLEVIWVINYLLYRPMFQNIVNLLTNMGLHVTFTVGLGLLASISSQRCLSILFPIWYRNHHPKRGPMVVCGILWLMSLLLNPPKVYYCVVRMEELPPSGCDLMSKLSGTLMLSMLILMTLSSLILFIRVLWSAKRYKPKKLVILILLTVSVFLLCAVPHGINHSVFNWRAMYNHTFHEISYFLSCVNSSANPLIYFFIGSLKHQRLKEPLRVVLQRALRDDSDLTEDRGTSSRTDTTLDAPS
The following text describes a protein:
Function:
Required for high-level post-exponential phase expression of a series of secreted proteins.
Sequence:
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQDPYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYYLETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEAINNLH
The following text describes a protein:
Function:
Involved in phospholipid biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 1910 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFAAIASGNPLQLSVEVPNSNGLQHTIVLSRTKPKLYSHITLFILPNVTFPQDYIATVYFKLSPQEEFKLFGYLSSEKPSAIFKVQIPSSKKDAGDTSDGLGEIDMDVDDGSGAADPFTDTNGSSSNNISELIIGISIEPREQGMMKLEEWKASMNAEAQKNNSLILSRPNLGIIRNITTAGQLAQVYPSLTQELAAKIVQHAYNYLSGFLDAQGNVPIKRFDTWWDKFRNRLANDGTFLDEVTKN
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses. In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes.
Sequence:
MFGNLKKKLSSAIQEGLVISENLQQQYRQRVSSGNSGSSQASGITTPISPLGLNESLSSSRSSSLSLSAPFQLTDGVPSHLNVAAGCSLLAKYEDDWQQIHGANEKNAEKAAQIANQISGIQDQASHQHRIMSELNSSLAGIPTLIAQLQNSSQVLNSLEEMGKQLEIELEKLEDLREECELQEFILEQQFQLSRHKQKKLNELEQYRQQIAQKHQSKIKDQEQTLLKLQRERQAVFDDAFREDMEEYKQRGQLTKIQTTSNKLALEEVVLEANEVETKDALEQFLNG
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MLGDTALKLVHDSRRTAALDLLPAYQEELVRGVCREIRQLDASINKTQDEPGYDPQDRVAHCNLLVQHLAMRRDKRCLLAYQFTRARRMNEAAWKQTEEPNLNGNEQEYMKAYEDLIVDIKGPYTDIDLTGSLEPPNDVFIDVRVLQSVGEVQTEYGVFNLEKDSQFFVRRSDVQTLLLQGYLKEI
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MDTAERAYEKFQNQMIAFDNLKIEMNELAVDLDQQLSDKQSLILQQEQDHKQKVNDLTNQEYKLKLQAKSLKEKENATRDKLNLAMRSLEQQKSKVEDLVKKKQSLVDTKQDLESQIKQLETAIDQGTRELNKSNDNMSLQMNKNLVELNKYEIYTGLKIEVQSNELMCFKFFNLDPNDYDREFAITLNIGGSTYSIENTSPKLSDETVEQIQGKLNQGRQLSKFLKEVRTLFKDFVQY
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEGDAYEDFMMSEDEEMHYAEMEEDSDEMGVYEEETSQGAEEEVPLDPSSSIVEGRYYRAKGLKENSKFREAIEALEGVATSSEPLWAFRALKQIAKCWNFKGAQASEGYQDGVRTALVRLLEHGLRWRQKLGAAYVERSLISTLRMLVPANSQNFVFDEAHEICLPTIEFHLRLLDAVAPLPGDFKDLCTLHMQLRLENLIWRERLRGADCTAILSEAPAPQLTAETLLLLLQCHICRFLRLCQPPAQQFAELVSELQDRAERSLALAQQPHAMVLLAFAQCMRGMQQQPQPHSALRTHFSACLQGLEEIGSNSSFFRDLNLCGFVLADALAYSAGRCSHRVDPFALEQIRILRETPIVHNLQLLYESYVALDLPSFARALDLLAPFRSALAPLFARLCALARERKLWDAIAPLHSCIALADIQRLLCIGSSSLSRDSLLTLMMQGVMASSARVPFRLDLTRDYVYFGDEPRVQLRAPAARPGLRHCAHDLGLTSACARPFQGSSALQLMDCLSEHRNRAASAAADPADAVCRARQPLAAYRTLAALILDE
The following text describes a protein:
Function:
Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.
Sequence:
MQPQIILITGASSGFGKITAQMLSEQGHIVYGTSRKPSENIGKVRMLVVDVTNSISVRQAVEQIISEQGRMDVLINNAGMGIGGALELATEEEVSMQMNTNFFGVVNMCKAVLPYMRKARRGKIINISSIGGVMGIPYQGFYSASKFAVEGYSEALALEVHPFHIKVCLVQPGDFNTGFTDNRNISELTGQNEDYADSFLRSLKIIEKEERNGCHPRKLGAAICKIVARKNPPFRTKVGPLVQVLFAKSKSWLPDNMMQYALRIFYAIR
The following text describes a protein:
Function:
Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKNLSETEAEVTMQENVVHESLPQIPVATSVSCCFVLAVLYVGSLYIWSTKHNRDHPTTVKRRFASVSMVMLAAPFFVYFFSSPELLSRVPFPKLLGLRLEGLWQAVVIPYSLTVLLFLGPIFVNMQNESVRSYFDLDYWRGSFGSIIWVRNHVIAPLSEEFVFRACMMPLILQSFSPLVAVFITPLFFGVAHLHHIAERLSLGVELSTALLIGLFQFIYTTLFGFYSAFLFARTGHVMAPILVHAFCNHMGLPDLQDLWQQDLWRRVVAIILYLAGFVGWMFLVPLATDPSIYDNTLYWNA
The following text describes a protein:
Function:
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MLSRSRIALSASYALLNASKRSVGKIVQPSIVILNNRCISQSPRLAKENAVQTTSNRTLKELIEEKTGTSGPYVLGGGILAYLLSKEMLVLHTETLIALSIFGVSYGIIRKVGKPTAEFLDQQGDEILDTLNEGRNMQMERLQEAIEAEKGIERMFDSRNEIFEVMKENNAMKLELEYRKRQQHVYEEVKKRLDYQVEVEQTKRRQEKEHIVGWLEQEVVKSISAQQEKDFLSQCFVDLKAISSSNRL
The following text describes a protein:
Function:
Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MFKDHQSLIPNEIRDLLDLSSVGKSSPGALLTGCSAGGLSTILRCDDFKSLFPLSTKVKCMRDAGFFLDTVDISGGRTLRRMYSGVVNTQCFFPQNIISQVMTPLYILNSAFDSWQIGNSLAPPSADSSGSWHDCSFMFRCNAAQKKVLEGFRISMLNALETFLTTRKNGVLITSGGKQAPFLQRLDQRGLLDLETDWMGLIELTCLPPAGIVATQRAPWLIWSLWTAPKDWQNAQCQDEPKKPSQRKIEDVPHYDTVLQTDAAWTETTGTAGLGWAIKTARETQRFSSSTTFVISPLMAESLAMREAIKKSKELGIRRLRCE
The following text describes a protein:
Function:
Pre-ribosomal factor involved in 60S ribosomal protein subunit export from the nucleus.
Miscellaneous:
MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm and is re-imported by the KAP123 karyopherin.
Sequence:
MWEQRRQKVVFSLTILVRYRLKQSMAKKISKNSRAARQSDALEPEVKDLSELPRAEKTDLTNILIRTAAKNEALLEAKISKKANKSKRGKKLNKKALEDKLANSISSMDRDRLVKALNFTNRLDGKIAKSISRAKYIQNTRKAGWDSTNETIKKELAFLNGGLSVQAKSASEGNAEKEDEEIPEVFDSLAEDNTVQKTPTNRFGVLPDDVEE
The following text describes a protein:
Function:
Functions as part of radial spoke complexes in the axoneme of sperm flagella that play an important part in motility. The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MTDNAIPGPLDPEELQIQYAKSFLLQTDNSGLSLYEHLSALLSRILSERPPNALEVFESLSAELHWSRLKQGSDVLRAPREESHTCRKAEVQRALFSRGDGEGEESEAEGEMTESPLPNLLDLAHLLQQGGVNLGRDEAVRISLALKRLTDTHPLQVCHFWGKILGSGGSYLVAEVQFREGEDDEAEEGGEEEEKGEVEDDVEEEENEEAEDLPPKSTYRPPPVIPKEENGTGANKHVYYVCSEAGAEWVRLPPVTPAQISAARKIRHLFTGNLDAPVITYPPFPGTEINLLRAQIARISAGTHVSPLGYYQFGEEEGEEEEEGAVRDTYEENPDFEGIPVSELVESLSNWVHHVQHILPQGRCVWVNTSVKSEEEEDEEEAEEEEKEEENEPEPEVGPPLLTPLSEDAEIGQTPPWTAFLSTHLIPHYALAVLRSNLWPGAYTVSSAKKFENIYIGWGLKYMPEGYSPPAPPAPQAEYPSGPEITESTDPTVEEEQALKAAKEEAEAAAEEMEEEEDEEEEEEDD
The following text describes a protein:
Function:
Endoplasmic reticulum palmitoyl acyltransferase that probably catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (By similarity). Could also function as a stearoyltransferase (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity; The C-terminal di-lysine motif confers endoplasmic reticulum localization.
Sequence:
MNILSAIIVFENLHEVKRLFHWGPIIALTVIGVCSSMAILDSIIWYWPLDTTGGSINFIMLINWTVLILYNYFNAMFVGPGYIPLEWKPEKQQDIMYLQFCRLCQGYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGHLNHAYFTSFLLLAPLGCIHAALIFIMTMYTQLYDRISFGWSSVKIDMSAARHIHHPIMPFSIAAFAATLFALGLALGTTIAVGMLFFIQMKVILRNRTSIEAWIEEKAKDRIQYYQTGEDFIFPYDLGSRWENFKQVFTWSGAPMGDGIEWPVHEKCDQYTLTIEQLKQKHDKRQRSVEYRVVEEYNGACCPLGKGLNTFFRTPCTEEPRIKLTKGETIFATRGTKWWMYGDKVLNEEQAKAGVRIRGWFPRRCVEKCLYDSANNSTSEEKKEQ
The following text describes a protein:
Function:
Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein.
Sequence:
MSRENNCTTADLAWGIPSITQAWGLWALFGVVTMLLLISLAALLSQWTRGRRRTQEEQGPPSGRSVEEVPLYGNLHYLQTGRLSEESRSEEQDPSSGGLARGAEEATCYTSLQLRPAQGRIPSSGTPIKYCEVVLDSEPKPQASGPEPELYASVCAQTRRARASFPDQAYANSQPAPS
The following text describes a protein:
Function:
Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MSPLPLRDPSHQANAGPRLVEPSCGPGVSLSNRTLCHPSWPMYDNWGRSPTTSERPEEEQVVSKDTGVPVRNYEDVFLLDPLLPCGQRVPLILTKPPQQAMDSRKLLLPPPIMSPSVHPSSSQACSSTWLSEAEMIALAGLLQMSQGEQTPNCVASSLPSTSCPDPVSVSEDPGPSGDQSCSGTDT
The following text describes a protein:
Function:
Acetylxylan esterase involved in the degradation of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Cleaves acetyl side groups from the xylose backbone units of the hemicellulolytic polymer xylan and xylo-oligosaccharides. Hydrolyzes about 20%-30% of the available acetyl groups on fully acetylated birch wood xylan. Completely deacetylates xylobiose peracetate (fully acetylated), and is active on both the alpha- and beta-forms of the sugar. Also hydrolyzes fully acetylated methyl-beta-D-xylopyranoside and methyl-beta-D-glucopyranoside, and the synthetic substrates 2-naphthyl acetate, 4-nitrophenyl acetate, 4-methylumbelliferyl acetate, and phenyl acetate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKIGSGEKLLFIGDSITDCGRARPEGEGSFGALGTGYVAYVVGLLQAVYPELGIRVVNKGISGNTVRDLKARWEEDVIAQKPDWVSIMIGINDVWRQYDLPFMKEKHVYLDEYEATLRSLVLETKPLVKGIILMTPFYIEGNEQDPMRRTMDQYGRVVKQIAEETNSLFVDTQAAFNEVLKTLYPAALAWDRVHPSVAGHMILARAFLREIGFEWVRSR
The following text describes a protein:
Function:
Catalyzes the phosphorolysis of maltose, leading to the formation of glucose and glucose 1-P.
Sequence:
MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNFEEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKIDLHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECLTGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTVLAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKELLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDARLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAAKLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGIDVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQSLESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELDPAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESSLSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGFAGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVYEEPVVLQGRCERRTPNE
The following text describes a protein:
Function:
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MYGIFASFRRGSQLENITLHARDLSSKISPSIARILKDAKRTNNGRKHPKISTLQLARTKRKFIQQGKEWPQEPLPPLNLKPYRKGHKWEEAKAARKVTIAENMAKMPQMIAEYREQVRERREKYRNRKDAAKKDPNQPEYVQYLLAKGVRLADIAVKLGTQNKKAKI
The following text describes a protein:
Function:
Component of the SRP (signal recognition particle) receptor (SR). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. GTP hydrolysis may enhance the fidelity of and provide unidirectionality to the targeting reaction (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.
Domain:
The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the signal recognition particle (SRP) complex subunit SRP54 (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). GTPase induced rearrangement of SR drives SRP-mediated cotranslational protein translocation into the ER (By similarity).
Sequence:
MIDLFAIVNKGGIVLWKKTNSLVNLKCLQVLFHEAFLSEQRTVNNTVTFDRYTMQYQEATQYSIVFVVVFQDLKCMAYSQSLLNSAHNIFLNLFKEKLEDRQVPNEAEVEKLFAPIFNRKSAQLENETDTKSLPVEANNDNSARKKNEYEMKKKGAQSKQTNAPKKGKKQLRKWDDQITEEEQAALNYSSQASSASQTVDNSQLSSIVGNNNKFQKTGSGDVIISDLEMDPNQTISNKSASSAFSLFSNLIGGKYLKEEDLSPILKQMQEHLTKKNVANSIALELCESVKASLINKKVGSFDTVKNTVNKAFRDRLTQILTPSTSLDLLHSIRSVRKNENRPYTISLIGVNGVGKSTTLAKIAYWLLSNNFRILVAACDTFRSGAIEQLGVHVKNLQSLKGSSIELFAQGYGKDSSFVVKNAVEYAKQNSFDVILIDTAGRRHNDQRLMGSLEKFTKATKLDKIFQVAEALVGTDSLAQAKHFQASLYHRPLDGFIISKVDTVGQLVGVMVGMVYAVRVPIIFVGIGQTYSDLRTLSVDWVVDQLMK
The following text describes a protein:
Function:
Reactivates suicidally inhibited ethanolamine ammonia-lyase (EAL), cyanocobalamin-inactivated EAL and O(2)-inactivated EAL; requires Mg(2+), ATP and adenosylcobalamin. Reactivation probably occurs by the ATP-dependent exchange of cobalamin.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MNTRQLLSVGIDIGTTTTQVIFSRLELVNRAAVSQVPRYEFIKREISWQSPVFFTPVDKQGGLKEAELKTLILEQYHAAGIEPESVDSGAIIITGESAKTRNARPAVMALSQSLGDFVVASAGPHLESVIAGHGAGAQTLSEQRLCRVLNIDIGGGTANYALFDAGKISGTACLNVGGRLLETDSHGRVVYAHKPGQMIVDECFGAGTDARSLTGAQLVQVTRRMAELIVEVIDGTLSPLAQALMQTGLLPAGVTPEIITLSGGVGECYRHQPADPFCFADIGPLLATALHDHPRLREMNVQFPAQTVRATVIGAGAHTLSLSGSTIWLEGVQLPLRNLPVAIPIDETDLVGAWQQALIQLDLDPKTDAYVLALPASLPVRYAAVLTVINALVDFVARFPNPHPLLVVAGQDFGKALGMLLRPQLQQLPLAVIDEVIVRAGDYIDIGTPLFGGSVVPVTVKSLAFPS
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MKDSAILNQLKVVLPPHIMEIIYFRYNQIDTYLKPYNLPIKTDVLLLALFTLIFIIIISKLFGSSGNKTRSVGGRTSNDKKVKRGVNIAILGLSNAGKTALLLNLTNVDKKISTHTSITTNNGVYITENKKKLPIIDVPGNGKAKASLPKILSNSACIIYVIDGTTFIDNSTQEAQYLYDILTNESVYQKKIPVLVFNNKMDLDSTIDTEQVKNILERELDDLRRTRGATPIVLGQEEDKKDIYLGIEGTPFQFDHLPNDVQFSNGSASPSNGELKEIDDIKNFIQTTTL
The following text describes a protein:
Function:
Component of the transition zone in primary cilia. Required for ciliogenesis.
Subcellular Localization:
Cell projection, cilium. Membrane; Multi-pass membrane protein.
Sequence:
METTARVHQPKAGSSSSRHRSSRARRSATPQRLEQLEQSEARGIDDVSSQQSPDQEMAMADGTSKNRTTAPSRTVRRPDTPEHSGASSTTTNASGSVTGMTVPDSGALSRVSQTPRSNSPAIVTTELVAEQAPPVASEEPAAGPPADKLQKGILGYMDRQLKVQSLSDSQKSPAQRSTRSSTRSSNLDKSPRRKRSKSESRRRRERKILAAGEMEVRQANETLMRYLKQCSDFNDASLSGDLEIPEPLEDRRVHRKTKSQRERKQHQPQQPDHRSGGRTHADDLMSYHGEIYNPFTPVVSPTTEAAATRIDKMYIQTASGYRPVDNTYSYHKSRALIGGDPESNSHTISTSVHLSCAVQRVWHLLSTVCHGLLGGLAFAHLLLICTTKPYDWVDASIHHYSAFAEVYANTFYCLAIVCMVSIFDRMDIAYGGDTNISFRSIFIIMIYVMTIILSLSAGTMDERLYVTASLNVTVWEEELETNKVLSVWNALSIARSVGAIFGWLIVGFLPNQDNLYDQLLEMEKYQLQ
The following text describes a protein:
Function:
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MESDPPPTSPSRAQPGRSQLNATSSAAGNEDPQRQGPTPGDHATPPPGRAEPEKNETVKDVTELSLEELLEKAKAGDPKAQTEAGKYYLKLAEDADEELNNSNAIDWLILAAKQGRREAVKLLRRCLADRRGITTENEQEVKKLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGEKQPGPIPKSIQKQRRMLERLVSSEAKSYFALDDFVEITKKYAKGIIPSQLFVQDDDDDELAGKTPEDLPLRLKVVKFPLHAIMEIKEYLIEMASKAGMHWLSTIVPTHHINALLFFFVISNLTVEFFAFFIPLVIFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYVYFLLSVAFVIFSFPVASKECIPCSELAVVSLFFTATSYMSLSTCAEPFTRRALLTEVAAGALSLLPHVPLSLGPLALLGQTFWTVPVGSLVVLNVSVPCLLFVYLFYLLFRMARLRNFQGTYCYLVPYLVCFMWCELSVVILRESSGLGLVRATVGYFLFLFALPVLAVGLALMGAVQLAKWFASLELAKMVATAGLCAVPLLARRWTRASLSPAGVVRSLSRSSVVKLILVWLTAVVAFCWFYVYRSEGMKVYNSTLSWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAEAAINVLPFFLGDWLRCLYGEPYPACDPARDPAHNPAPREEDLCRLKALAKHRCHMKRFDRYKFEITVGMPYGAAGKTPEEDDITKDVVLRASHEFKDVLLHLRQGSVIEFSTILEGRLGSKWPVFELKAIGCLNCMAKLIPSGRHVKIEHDWRSTVHTALKFAFDFFFFPFLAVA
The following text describes a protein:
Function:
GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Also acts as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, lamellipodium. Note=During chemotaxis, localizes at the leading edge of cells, whereas in response to cAMP stimulation, rapidly and transiently translocates to the cortex. Localizes to F-actin-rich regions. During macropinocytosis, strongly localizes to crowns and remains there for a short time after the cups were enclosed. During phagocytosis of heat-killed yeast, strongly localizes to phagocytic cups with F-actin. During cytokinesis, mainly colocalizes with F-actin at filopodia or lamellipodia of daughter cells.
Domain:
The N-terminus (residues 1262 to 1601) functions to regulate both GflB-GEF activity and its localization at the leading edge of cells by binding F-actin directly.
Sequence:
MTDLNSESFSALNFWKSVEKKNISTNFQGTKVVAPSKKINSFPLLAPPAPPPPPTEQEINIGSGNSTFISSNNNNSNNNNNNNSNNNNNNNLNNSNNNNNNLNSNNNNNNNNNNNNNNGNNNNNSNFLTRQDSSTQKEWDEQNVTEAFGFWKQKAVQLQKETERYNARRNARQTIDLTNILRKSTSSDLLIKPPVESPPLTPVGQDDEGEQQQQQQQQKQSSPSTPSNDTDTETTAAAVTTTTTTTTTTTTSTTTTTTETVLQANQLEIKYGGETIAVVDDSGTTPRDYRRSRSISCEIIPKINGVITTSPQRVTTTTTTTTPSTGGVVVADEESDSSEEESDSSEEESDEYTDEESETELQVVSNATPRRSDDFTPTIVESPPLTSVNSNDNTSSGTVVAPIDLNSSTGGNTGSQQPPQPSSQQQKPDQASENTAVAASSISATTNVTSAASTTTVAPDSIINTKDVTVVSSTLTTTTSATSSTTSATTQSIPAPPSPSQQRAAQSISTSSVTPAAITKPTKDAKDKKDPAKKSIGATLTRTVTKTFIRDSKENNKVPTGTSPPVSSSTSISSSTGIKKDKVKLSKEEKDRIKKEKSAKKKKEKDEKKQQKTNKKALTKNNSSTDVKKGFVSPQQQQILDSPYRIYGVRLTQLVLSNDGDLPAILTQTITVLSNSNKLDVNSVFVGAENEPAVREIRKRSDLERIDFSIIGDPRVVAGLLILFFAELPQPLFNSKFFGDLVEINDITNPQVKLNDLKQLINSLSQLRRSLLQILVTFFTSKYINGNSVTTRAIAIQSIAQSFGPQFFRGTSSSDSDIQVGIETLKLIIDNYVFLFEKTNEPDVKYKNIDGKMIISEGSIDKLIDKATDQYYPYNEKYFSLTFFITHLFFIQPHELADKLITLYRENLDTLETKKKWKKHRRSKKASFINEAVKLWVDYCYKEMREDKELSKKILKGFPHLEAQLASRLSHRTTINDFLKLPKRVHSRTRSASFSDTLLSTGGIGSTSGGIGGGVNNCLLSAMEIAEQCTLVDYDLFTNVRLSDWVRLVQGSVDPQTAPSLSLALKRSTIWAQWAMGEILSTEDKSQRVAIINLLVDVAINCKDLANFNTAISIHTALTNHHIKRLQQTWDSVPKETLNKITQLEQSLQVWLKPDATNPFGVICQSINSACVPNFSILRTILSQIDQKIPTFSNDGSMVNVEKLRTIFGIVVEIQRLQQQRNYTMKPTKLFIQLQDINTVSMDELADLSLKCEPPVSKAKKYNAPADIVDEDWRLKITKTFNKPLATTSVGIDLPRLASSFTFNTTGHKTTPEEKSAYGNKIQDIFHVLVSLAQIESSELETDVREKFTTYIPMSTDPDSDFKRELLKFLDEVCHADNSKLVRVLKCCNQAIIAPVIIEITLNIAKGVPFMDAGGWRILISNINNSNNSVILDKIDEINEDSSNVEKEKLSSSQEQQEQQEQKQQEQQQQQQEPQPLFIRHYKKQRSRSAQSKDFFEFEWFIQLNLDADCKNILSFDLKISNLVFSTDTSPNIRDQLLESFKSYLVSQECVQYINFNENKQPVAAPVTPATTIVTTKEESTTVTSSTTTVVQESVPSTNAE
The following text describes a protein:
Function:
Plays an important role in cell growth. Required to keep the uninucleated state. Modulates morphogenesis during bud growth via directing organization of the actin cytoskeleton and the position of the secretory machinery for exocytosis.
Miscellaneous:
MISCELLANEOUS: Present with 5910 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSFLCGSASTSNKPIERKIVILGDGACGKTSLLNVFTRGYFPEVYEPTVFENYIHDIFVDSKHITLSLWDTAGQEEFDRLRSLSYSDTQCIMLCFSIDSRDSLENVQNKWVGEITDHCEGVKLVLVALKCDLRNNENESNAITPNNIQQDNSVSNDNGNNINSTSNGKNLISYEEGLAMAKKIGALRYLECSAKLNKGVNEAFTEAARVALTAGPVATEVKSDSGSSCTIM
The following text describes a protein:
Function:
The C-terminal part of CwlO shows a cell wall hydrolytic DL-endopeptidase activity.
Miscellaneous:
MISCELLANEOUS: The N-terminal part of CwlO was shown to have no cell wall-binding activity.
Subcellular Localization:
Secreted. Secreted, cell wall.
Sequence:
MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQSEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKKLKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSIVDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFDEAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKASDETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGGTVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNLGPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGVSVDSMSNPYWKAAFKGVVRRVVQ