lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis. Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells. Regulation of NK cell activity by adapters Sh2d1b and Sh2d1b2 is reported conflictingly. Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (By similarity). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells. Inhibits inflammatory responses in dendritic cells (DCs).
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cell membrane. Membrane raft. Note=Receptor engagement results in a recruitment to lipid drafts essential for the subsequent tyrosine phosphorylation of the ITSMs.
Domain:
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Sequence:
MLGQAVLFTTFLLLRAHQGQDCPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQGSHRKIEILNWYNDGPSWSNVSFSDIYGFDYGDFALSIKSAKLQDSGHYLLEITNTGGKVCNKNFQLLILDHVETPNLKAQWKPWTNGTCQLFLSCLVTKDDNVSYALYRGSTLISNQRNSTHWENQIDASSLHTYTCNVSNRASWANHTLNFTHGCQSVPSNFRFLPFGVIIVILVTLFLGAIICFCVWTKKRKQLQFSPKEPLTIYEYVKDSRASRDQQGCSRASGSPSAVQEDGRGQRELDRRVSEVLEQLPQQTFPGDRGTMYSMIQCKPSDSTSQEKCTVYSVVQPSRKSGSKKRNQNSSLSCTVYEEVGNPWLKAHNPARLSRRELENFDVYS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MKSLFKVTLLATAMTLTLNTSTVFAADATSPVVTNSAFKNNDQQSAYALGASLGRYMDNSLKEQEKLGIKLDKDQLIAGVQDAFANKSKLTDEEIEKTLQNFEARVKASAQAKMEQDAKENADKGAKYRDTFAKEKGVKKTASGLLYKVENAGTGDAPKDSDTVVVNYKGTLADGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKQIKKGGKITLVIPPELAYGKAGVPGIPANSTLIFDVELLDVKAAAKADAQEQQPAVDTKAKK
The following text describes a protein:
Function:
Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Exhibits low basal ATPase activity, and unable to polymerize. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
Miscellaneous:
MISCELLANEOUS: Present with 1010 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton.
Sequence:
MSQEEAESSIIYEEPIDIPLEDDDDEDELEEENSVPLSSQADQENAENESDDSVDNVVGSETPRSVTGLSVDPRDVADEEDEDEEGEDEDEDEDDNDVDNEDENDNDNANENENELGSSRDKRAPPAVQTSKRYKKYPKLDPAKAPPGKKVPLHLLEKRRLGRIKAAEEFAKTLKKIGIEKVETTTLPATGLFQPLMLINQKNYSSDYLKKDDQIFALRDRKFLRNNNTSQISSTNTPDVIDLKSLPHSEASAAPLNDEIDLNDPTATIVIHPGSNSIKIGFPKDDHPVVVPNCVAVPKKWLDLENSEHVENVCLQREQSEEFNNIKSEMEKNFRERMRYYKRKVPGNAHEQVVSFNENSKPEIISEKNDPSPIEWIFDDSKLYYGSDALRCVDEKFVIRKPFRGGSFNVKSPYYKSLAELISDVTKLLEHALNSETLNVKPTKFNQYKVVLVIPDIFKKSHVETFIRVLLTELQFQAVAIIQESLATCYGAGISTSTCVVNIGAAETRIACVDEGTVLEHSAITLDYGGDDITRLFALFLLQSDFPLQDWKIDSKHGWLLAERLKKNFTTFQDADVAVQLYNFMNRSPNQPTEKYEFKLFDEVMLAPLALFFPQIFKLIRTSSHKNSSLEFQLPESRDLFTNELNDWNSLSQFESKEGNLYCDLNDDLKILNRILDAHNIIDQLQDKPENYGNTLKENFAPLEKAIVQSIANASITADVTRMNSFYSNILIVGGSSKIPALDFILTDRINIWRPSLLSSASFPQFYKKLTKEIKDLEGHYVNAPDKTEDENKQILQAQIKEKIVEELEEQHQNIEHQNGNEHIFPVSIIPPPRDMNPALIIWKGASVLAQIKLVEELFITNSDWDVHGSRILQYKCIFTY
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAPCPRVPVSSRWLYSGRGCRLLKFDWEICLNTRRSAPQWDILNGKKVQRGRHGLHGQNPAKPEGRHTKERMAAGLLTTWSQELVTFEEVSVDFSQEEWALLAPTQKILYRDVMLENFRNLASVGYHLCKHSPITEVAQEELRPEGRGILQSACTDGATQLKSKDVILMQNVPGEKTANGIKMVRFTRNDSCFLRLGDLCEFQEIKTAAAPKQEETLEAPTLPGEKPLECDHCRKFFRKNYHLIRTRYCKGKKCYKYKEYGRDFGHPSTLRNHLCTHIGEKILEFSDCGKTFNQESPLRKHFRTLTGEKSECNQHLISKLHSSFSVHKQIPTEEKLHEHSDCGKRSFHSVHKKMCTVKESSKCNGHGKVFTGPLSLQICLRPHTGEKAYECRDCGKAFVFQSSLKKHVRSHTGEKPYECNHCGKSFSQSSHLNVHKRTHTGEKPYDCKECGKAFTVPSSLQKHMRTHTGEKPYECSDCGKAFIDQSSLKKHTRSHTGEKPYECNHCGKSFSTGSYLIVHKRAHTGEKTYACKECGKAFRNSSCLRVHMRTHTGEKPYKCIQCGKAFSTSTNLIMHKRIHTGQKLCE
The following text describes a protein:
Function:
Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.
Subcellular Localization:
Apical cell membrane.
Sequence:
MWSTQDVSDTKNMLDKNKKSGYWIVAVAVILCFATGILIGRYGTTSVADYHNFDVRNLVIDEISAEEIDSNLRYLTSTPHVAGTAQDLLQAEWMRDRFLEAGLDEAKTVPYDVLLSYPRVGVMNKVSLIDEQGRINYTTAGRQPPLGSPEEFSDDILHNFNAFSANGVVEGNVVYVHYGRKKDYEYLLSRGINVSGHIALIRLGAIFRGSKVDLAERYGAIGVILFSDRLEKTSQNRNNTYPDSWWMPGTGAEYGHVGRLRGGDLLTPFYPAIESAFRIKEENHPGLPKIPVQAIGYEEAEVILRNISPENSAPTKWIGKMDAPYSLGPSLRNPGWRVRLDVSTVNERRTTFNTIGILRGSVEDDRYVLLGNHRDAWTFGALDPSSGTASMIEIARVFGKMKRDQHWRPRRTIVFCSWGAHEYGLVGSYEWTQQHATVLGQRAVAYLNVDTAVSGNRTLFGNAFPTLKQLLIDTAKLIPNPSVHEIESGHKTVFDTWLAQSRDRDNVDQPMVGHLGGGSDFEGFSYVIGIPAADFGYMKNGVYPTQYSLYDSYHLASNIVDRGFVHHQAVARMWAVAAVTLSDSVILPFDVLAYASYLNHSLSLLHTKYGPILQQNGVSLKHVRVSVDHFMFSVKHFSENELKNVDQSNIFAVRRVNDKLMYLERFFIDSKGLPDHPETNHVVFSTSSSDSHNFNTFAGLVDLVVQVENKTESNDPEIWSKIRHHLSVIAFLIGEAGRSLNGDF
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MSVAASFPKHTSFTMRASFAAADGLPETENNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQRGEGVFMAARCFWDADTDNCTHDVFMNDSLFCVVAAFGCFYY
The following text describes a protein:
Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MLRFPVKKIRKQFKLLLLLVLLTFAVWFTYLHINQGKSIKLHFNYGKDGERPMEGTDTSHKRDSRSSDKYRKSEDASNSQEEDNTQEDEPNAGTAHNKDQAEIRKLLAQKYKKLPWKPEFKGQANLHVFEDWCGSSVAQLRKNLHFPLYPHTRTTVKKLAVAPKWKNYGLRIFGYILPYKDGDFQFAVSSDDNSEFWLSSDESPLNARLLAYVGKLGSEWTAPGEFTKFRSQASKSVHLMASRRYYFEILHKQDDKGSDHVEVGWRPFLPGLKYEVIDSAYISLYTDESSLKMNHVDHIPQTLASHSRVPAETHIHSQHGADMLQPDPRDTFFNIPMIDPAHLENVLPACLYSPTYVVKDFPIARYQGLQFVYLSFVYPNDFTRLTHMEKENKCFYRESPIYLEKFGFYKYMKMDEEEDDRPFFFPNPDDFLEEEEGVDPDDEAQVVGTQSAKKTIQPSQSTHTLSPSDKPVPTMLDRKEVEPGNPALRREQRRFFASARQPVVPEAQEMEKDTPDHQINVGSPKSESVVRGRSLAWVQRDRREGWSEERSPKISRTALLFPPKSSLVALNSRAKQILSNPNPSPANNHAHDNNRNPGNIHANKEHKKEDNKIYVTRPRPAREKQGLVSRHPREVFPGVFLYQNGKTTKLVNLSAKPKLGKGPLRASQLFARSPLQESKVFPASPNFSNPIPPNRAAIPSHFERRIRGVWEKHQHPLRPVTTLRPTPQSSNSSENVPPTESVRVTSYMHTSQITESQQQRPDTDLEPEEDGGLSEYSYEDVEPRPGWAEEAINWQRTFSVNSMDFESLRSDWNDLRCNVSGNLQLSESEVVDVLAQYMEKLNERNGGIYTLLRIINVEKRRDSARGNRYLVELELMERGRKIVRLSEYIYMLLHRGRAEDSLENVEGVTASSPSSPVASPPAQPSHTPTRGARGTPQWGTVYAKPLLCQPVMLRWKKDVMVHFVVPVKNQARWVQQFISDMESLHSETKDNNFNIIIVDFQSEDMDVEQALRESTVPRYEYLRREGNFERSAGLQIGVDTIEDSHSIVFLCDLHIHFPPNILENIRKHCVEGKLAFAPIVMRLGCGSSPLEPDGYWEVNGFGLFGIYKSDFDKIGGMNTEEFKDRWGGEDWELLDRVLQNGLEVERLRLRNFFHYYHSKRGMWNSQSSKTPK
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MPDSNAQGSREKESGHHRSHKERIGNYVVGAEIGRGSFATVYKGYRSKTRVPIAIKAVSRQKLTSKLLENLESEINILKVINHRNIVALTDCFKNDTHIYLVMEYCSGSDLSVYIKQRGNIPTLDFVPKAGSSMALLPTDDEGKIYWPHPPTGGLDERVTRSFLGQLAQAIKFLRAQDLMHRDIKPQNLLLQPATETEVAEGHPYGIPVLKVADFGFARILPAAAMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLFEMSVGRPPFRANNHVELLRRIEKSNDNIVFPDEKERDSKSSDETSIPVPSDIKALIRALLKRKPNDRMGFDDFFNCGVWDGHMAESTEEESLSLDVSTDSSAGLGESDRIRQMVASTEQSKDRLIPTRAPQPLAADAALNPQPAVPISRDTSEGRSRLSTPPSRPTPTRRSTPKYYVGDATPSEPTAIIPPSPSSAPTPTSAPDPGLTTQQSPTSRANPRPIITAASSAQRRMSGKGDGREASSVEEAAPITPPFAGPSPTMARPSRGINEGSPLAAAPPITMGPDGRLERSSALEGSTSGVGTDYVVVEKQTVEINALADELDQASKRPMIRRSSRGSVVSRPVSSFKPISPNIAKNDPTLGPISYSPPFALSSTPPFAMQVPRHASGGNSFPRNPSIPSSLNAFPPTTISASPSYGQDAAARFGVSPGSLQTGALARALTNTAIRLIGTSANTAATAIARATAKRRPNIVRVSDMDAAEDDLLCTVEDLARKAFVLFELADERLLAQTQLAQTARTSSTPTGLTGTTPPFSMQAAAAAQAGSRRKSSSSSMNSEVWILRQQEAAANDAVVLYMKSLAFIVKAMDKVKRYWKNRTDVYDGYVASQELNEMGQWLRARFNETFEKAEWAKTQAGDTLLFPDWLVHDKARDTSRQAAVAELQGDLTTAEQGYETSLWLLQALLDESVYENGSIPDEDKVAYDRLMVPIKTRLDALRKKLAESSGMTAR
The following text describes a protein:
Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MLTLPPGLTEEEEALQKRFAKLRKKKKALLALKKQQSNTGPSSQGGIKRSMSDQPPVDTATATEQAKLLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPAPTFQPFQRSVSADDDTPESRRPQRKSLYESFVSASERLREPEAGGGRGDPPERGERDRRLDWEQEPEPEERGGREREASFRRSDSFPERPSPRKGNTLYVHGAELSPELLRSAFSPFGAIIDLSLDSPRNCAFVTYEKMESADQAMAELNGAVVQDVQLRVSIARKQPLLDAATGKSLWGSLAVKNSAKGSHRDKRAQVVYNEDLFGGQ
The following text describes a protein:
Function:
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MQHYIIYMGDHSHPNSESVVRANHEILASVTGSLDDAKTSALHHYSKSFRGFSAMITLEQANKLAEYDSVVSVFESKMSKLHTTHSWDFLRLNPVYDKNHVPLDFTSNVIVGVIDSGVWPESESFNDYGLGPVPEKFKGECVTGDNFTLANCNKKIIGARFYSKGFELEFGPLEDFNKIFFRSARDNDGHGTHTASTIAGRNVVNASLFGMAKGTARGGAPGARLAIYKACWFNFCNDADVLSAMDDAIHDGVDILSLSLGPDPPQPIYFEDGISIGAFHAFQKGILVSASAGNSVFPRTASNVAPWILTVAASTVDREFSSNIYLGNSKVLKGYSLNPVKMEHSYGLIYGSVAAAPGVPETNASFCKNNTLDPSLINGKIVICTIESFADNRREKAITIKQGGGVGMILIDHNAKEIGFQFVIPSTLIGQDSVEELQAYIKTEKNPIAKIYPTITVVGTKPAPEAAAFSSMGPNIITPDIIKPDITGPGVNILAAWSPVATEATVEHRPVDYNIISGTSMSCPHISAVATIIKSYHPTWSPAAIMSAIMTTATVMDNTNHLIGRDPNGTQTTPFDYGSGHVNPLASLNPGLVYDFSSQDALDFLCSTGASPSQLKNITGELTQCQKTPTPSYNFNYPSIGVSNLNGSLSVYRTVTFYGQEPAVYVASVESPFGVNVTVTPVALKFWKTGEKLTFRVDFNPFVNSNGNFVFGALTWKNGKQRVRSPIGVNVVSI
The following text describes a protein:
Function:
Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDMTVSNQKAESDDGSDIDDAALLQKINSLPIDQSITNSVSLEKHDFQGSDDHDSSTDLSDSTLEDVEGSEWADVSRGRYFGSDPSESIVCHNCKGNGHISKDCPHVLCTTCGAIDDHISVRCPWTKKCMNCGLLGHIAARCSEPRKRGPRVCRTCHTDTHTSSTCPLIWRYYVEKEHPVRIDVSEVRKFCYNCASDEHFGDDCTLPSRSNYPESTAFCEANCPSGNDASNKEFFETRRKEFQLERREQNRNQKSSKQRPFHKPGNSLASRLGSKPKSFKRKHSPPSEENGNLSFHSSDGRKFTKTSKKNRKRKW
The following text describes a protein:
Function:
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
Subcellular Localization:
Nucleus.
Sequence:
MDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVNIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPPFFEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGRPINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT
The following text describes a protein:
Function:
Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MEQINSNSRKKKQQLEVFKYFASVLTKEDKPISISNGMLDMPTVNSSKLTAGNGKPDTEKLTGELILTYDDFIELISSSKTIYSKFTDHSFNLNQIPKNVFGCIFFAIDEQNKGYLTLNDWFYFNNLLEYDNYHLIILYEFFRKFDVENLKAKQKKELGSSSFNLKAADDRIKSINYGNRFLSFDDLLLNLNQFKDTIRLLHESIDDNFVKDNKLLLDWNDFRFLKFYKCYHENEEYLSLNSLVTILQNDLKNEKIFIGFDRLAQMDSQGHRLALSKNQLTYLLRLFYSHRVSADIFSSLNLSNTELLKADNNSIPYNVFKDIFYLFQNFDLLNQIFHKYVTENNLNEQDIREQIVTKNDFMTVLNAQYNKVNNIIEFSPSQINLLFSIVANSKENRRLRKRNQDRDDELLNDHHYDSDIDFFIHNEYLHGVSRSRKNLESFNDYYHDLSDGFDQDSGVKKASKASTGLFESVFGGKKDKATMRSDLTIEDFMKILNPNYLNDLVHQMELQKNQNESLYINYYFYPIFDSLYNFSLGSIAGCIGATVVYPIDFIKTRMQAQRSLAQYKNSIDCLLKIISREGIKGLYSGLGPQLIGVAPEKAIKLTVNDFMRNRLTDKNGKLSLFPEIISGASAGACQVIFTNPLEIVKIRLQVQSDYVGENIQQANETATQIVKKLGLRGLYNGVAACLMRDVPFSAIYFPTYAHLKKDLFDFDPNDKTKRNRLKTWELLTAGAIAGMPAAFLTTPFDVIKTRLQIDPRKGETKYNGIFHAIRTILKEESFRSFFKGGGARVLRSSPQFGFTLAAYELFKGFIPSPDNKLKSREGRKRFCIDDDAGNEETVVHSNGELPQQKFYSDDRKHANYYYKSCQIAKTFIDLDNNFSRFDSSVYKNFQEHLRSING
The following text describes a protein:
Function:
Catalyzes the conversion of chorismate to isochorismate.
Sequence:
MYLKQNLMSYLAQAIGELKSQIHAYLQQSTNELVRFQVKLDKVDLLAWLKGQSAYPQFYLHFRDEEKALAALGAVQSFSQLNLAQEFIEESGFPLVGGLQFQGTAQFVLPKMLVEQDNKGTLVSFFVKNEQSANDTLAHLKTFENLTALSALPKQIPLHTELRANERTWCDWVNQALVEIKSGELTKIVLANETTFHLKQAINAYDFLAESEKQNQGCYHFLWAENSHSVFVGSTPERLFAREYNLLLTEALAGTASVSESEEETQSQANWLLNDEKNLKENWLVVEDISQNLRKQVESFDVSNVELKPLRKVQHLIRKIRANLTAHYADVNILKAIHPTAAVSGLPQQQAKMILSEIETFDRGWYAGTLGVMSDVCSEFCVAIRSAFIEGHRIRVFAGAGIVAGSQPLEEWKEIERKAAGLISLFAEEK
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MRLLITGTDTGVGKTFITYNLAKELKERGYKVGCLKPVETYVREVPEDGSLLSKATGQSVNEIVPVRFSLPLAPYAATLEEGRDFALEELGKHYEELSKKYKFLLVEGAGGIAVPIKKNYTYANLARDWKLKVLIVGRAGLGTINHTFLTWYYAKATGLEVIGIILNGFTGEDVSERTNPQIIEEMTGIKPYKVPRIQDVELPKDIRTGLADYVLSRFTP
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTRLKYWFNIGSFFETMKPNIRVLKLFGLFPYTISQAKGRSFPSNSHHSNNRCNHSKTLKSEVKFIDIAIFTLWQTFFLQMLYVSWPKMFLNMPVSRIITMVTLILYLLAGFNCSVSATLVLLFRKKFLHMVQLVEEADFLFSKYFYEIQHSKHHLVCVALLLGSFACQGLLILNDYTAGKMLVNTTLSLQSMPMQAITSYYYIIRSIHISCVVAFISGLYSFRDRFFAFNKQLRICFVEKHSGEQAASYRVLMNHIQGFTAIYSNLCDAIGIFCTIFAWQPMMFCASLIVTVVFSILTIGHMLTNSAPIVLALALIYSALTILYTLLFLVLVKLGSDLKREGKQTAVLVHKAINQSSKTPALVERLVLFSHHLQHQRPVVSCGLFCFDWTLALSIISALATYSVILIQFELGVPKFFISAILQQNGDMTTTNSQP
The following text describes a protein:
Function:
[Isoform 2]: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17); [Isoform 1]: Inhibitory immune receptor involved in the regulation of phagocytes.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Mainly detected in immune tissues and cells; MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
[Isoform 1]: Membrane; Single-pass membrane protein; [Isoform 2]: Secreted.
Domain:
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Both motives are required for full inhibition of FCER1A-mediated degranulation.
Sequence:
MTAEFLSLLCLGLCLGYEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDKHDELEAPSMKTDTRTIFVAIFSCISILLLFLSVFIIYRCSQHSSSSEESTKRTSHSKLPEQEAAEADLSNMERVSLSTADPQGVTYAELSTSALSEAASDTTQEPPGSHEYAALKV
The following text describes a protein:
Function:
Involved in purine nucleosides uptake. Could also be involved in uptake of nucleobases.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIFSSLFSVVGMAVLFLIAWVFSSNKRAINYRTIVSAFVIQVALGALALYVPLGREMLQGLASGIQSVISYGYEGVRFLFGNLAPNAKGDQGIGGFVFAINVLAIIIFFASLISLLYYLKIMPLFINLIGGALQKCLGTSRAESMSAAANIFVAHTEAPLVIKPYLKSMSDSEIFAVMCVGMASVAGPVLAGYASMGIPLPYLIAASFMSAPGGLLFAKIIYPQNETISSHADVSIEKHVNAIEAIANGASTGLNLALHVGAMLLAFVGMLALINGLLGVVGGFLGMEHLSLGLILGTLLKPLAFMLGIPWSQAGIAGEIIGIKIALNEFVGYMQLLPYLGDNPPLILSEKTKAIITFALCGFANLSSVAMLIGGLGSLVPKKKDLIVRLALKAVLVGTLSNFMSATIAGLFIGLNAH
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MDATLPLLTLPADTVVLPGVSMKVGLSKETAVAMLKLFEKPKDKDVAYSKATQDLMSSVNKLQAFFKLKRTSADGYRNASLITIACVPRITQKQIKETGENNEAGAHDSESVTPVLGTNSTEVNTSVYSFGTVCRIVRFERSGTEDFQIVVEGLSRLELGQLVDKSGLVPTARIKVRVDEDGESASSDESSDKEPTWSKTELSQLEVLHASAKEIIDLAAKSNATQFSKLMASQTTVAASVMKQLTKLGPNPGSARDTRKTAGMLVDLLMAILPTDFEDKIAVLAAFSIPERIAKGSEILKTKLDMMKITEKIDSTVDSKMNKQQREYLLRQKMRAIQEELGETDDRGEDDDLKELTQKLQSLKLSPEADKVVSRELKRIKRMPPTQAEYQVCRTYLETIAELPWDKCTEDTVVTVDQARTILDNDHYGLSHIKKRLLEYLAVLRLKSLRSESEVAQEETAAAASSEGPNGQLDDSAKPIDYSNRAPILLLVGPPGVGKTSLAKSVARALGRKFQRLSLGGVRDESEIRGHRRTYVGAMPGLFIQGLRQVGVNNPVVLLDEIDKIGGANFHGDPAAAMLEVLDPEQNATFRDHYINFPVDLSKCIFIATANNLDTIPAPLLDRMETVHLEGYTYMEKLHIAKKYLVPKQTKANGLEVDQVVIPDDVLLHICTKYTREAGVRNLERKIGAVCRAKAVDYAKSLSADDGELITVVDEAKKGAHSSYDPVVTIENLTDILGMEVYTDEDAQDAKEEPNSSHIGVVNGLAYMGTGNGGLLKFEATQMPGKGQLKLTGKLGDVIQESAQIALSWVKSNAAALHIDTDFDKVDIHLHAPAGAIPKDGPSAGVAMTLAFVSLFMGKPIPPSIAMTGEMTLRGRVLPVGGIREKLLGAHLAGVNRIMLPLANKRDVDEEQRKGGDGGVLDKMEISYVKYMWDVLELVWDLRFDPMIESRL
The following text describes a protein:
Function:
Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIRKPGVIALFDVDGTLTAPRKVATPNMLEFTQKLREVVTVGVVGGSDLAKISEQLGRTVIMIMIMSSLKMALSHTQSLKSFLGEEKLKEFIDFTLHYIADLDIPIKRGTFIEFRSGMLNVSPIGRNCSQEERDEFEKYDKVFPNGWDKTYCLRYLDDFLEIHFFGDKTYKVGNDYEIYESERTVGHKVTSPEDTEEQLYSSLPCYAQSKLLNLWQRQFHVFNFMSL
The following text describes a protein:
Function:
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MPVAIAAARYAALSAGASSSRSAIMLSSSHRALSTSSKVASSSSSSNRGTFSPTSPILFSASSSSSSSSSPSSSRELSHLSWDKYLQLRRSRRLAGMVTTIPTTLLAGAAAGSYFLTLELDPTNAIAGLDPVYINAGLTLACTGLGWLIGPTVGNSIWGLLHRSDAKQIAQKDHDFYEHIKRNRVDPTRQSVQNPVPDYYGEKIGSIKQYRQWLRDQAAFRRKAAHGLEQDA
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAQPLVAAPSSSSITSPIPRKLCSSLLTPSSLSLSSNPRNSLQFLNSKLFLSPPSTSHRRLSIVAMAPKPGKAKKVIGVIKLALEAGKATPAPPVGPALGSKGVNIMAFCKDYNARTADKPGFVIPVEITVFDDKSFTFILKTPPASVLLLKASGAEKGSKDPQMEKVGKITIDQLRGIATEKLPDLNCTTIESAMRIIAGTAANMGIDIDPPILVKKKKEVIF
The following text describes a protein:
Function:
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQVVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQGVLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLLWLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAAKKMIPNDERSS
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Sequence:
MDKPTTSAAAAAAQDSNLLPDSPQHGPTLSSASSFEALTRHDPNLSRLATKMFNKTEEYITHELNAPLEDYKLLEEMNKATIAKYKDMRQIAENLNTSTSELSLKFQQLAPMMQQIDEISDTVDKLEAAAYKLDAYSIALENRVKCVLQRKSGGGQVAQ