lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CatSper complex targeting and trafficking into the quadrilinear nanodomains. Targets the preassembled CatSper complexes to elongating flagella, where it links the channel-carrying vesicles and motor proteins.
Subcellular Localization:
Cell projection, cilium, flagellum membrane. Note=Specifically located in the principal piece of the sperm tail.
Sequence:
MELPPPGNRRVSINNPQETSGRVPTTSAGFPTQSSKISLKRSTYAYRPSMMSNRSSGGQSLLPSSILQKTSLNPPGSLQSKPSNLSSVHYADEEGKPLTDKNKDKDKGRGKGKGTGTRLLTMLRKTLQGSQSDEMAIANQTPNLIPFGDVVGCLAIHIKSCRQFSQRFLGQQRFNLFMRVSINNIVKCTKIRHLKAVNNEKNLVLRFGEMKYFSVQVPRRQDDERNFIYLELMHDGGDPESPPIPLGGAESHLYEVIQKGCFTEVMHLMHKNSSICRVEVEFMFSYGNFGYGFSHQLKPLQKAIEPSMFMNIAPPPERTDPVTNVITPQRVEYPAFLSPEFNVSIGVPEASHATVVQLEKLREKPRERLERMKEEYKNMSTWIEKADYLRNLINPKMTKRDNKGSSIPSESNSSALEELERTTYDIHHRKYEAISNEYGDKEGRVIPVLKVLDQNYSEVFLPKSSDSTPLEDVLLPPIHSLQIVEENEMPHLPKTSEPEDRPHEERKSIVFSSDEELMPKHPSILKISSSQQENRRKMEKSPHFSDVLIIPDKPFEDLNTNKKGRPPIELRKSWERHPTDVACSLRKVAFAQKDYTIPVCKAETTEFKPKHQFQKLSKSGLDPFLRNINSKMSFRKKKDHDDGYRNLSTSSAEILEHEDQDPPYPGHSGSAGSDATWAENPSPVTVQMVNRDSLPPDLITATIVISDRKNKLSLDSVFNSANSLNTKSIFASDNPVVSLTKLSDSDNKLITDSSFNTTKPSNRRLSKDSNFNTTKPSDRKLSSDPSSNTTKPSDTKLFSDPSSNKLSQGPSSNASQLSGSNRLSHNPSINGNKSSYTSDLNKVSRDPSIVSTISSDPNKLSRDPSFVLAKSSDPNKLSHYPSIISAKSSDPNKLSHDPSFVSARSSDPNKLSHDPSIISARSSDPIKLSRDPSFVSARSSDPNKLSHDPSIISARSSDPNKLSRDPSINSTKLSDPSKLSRDPSIFSTKSSDPNKLYRVPSIISGMSSNPKLSRDPSIISGMSSDPKLSRDPSIISAKSSDPNKLSHDPSIISGMSSNPNKLSHDPSIISMKLSDMSKLSRESSINASKSSDTNQLSYDPNIISAKSLDSNNSSASSSPTVNSDTTTNAAEPSGTKNMLDPVVSTIDSSDKQSKLEWLPNVQGASSVTENINTHRSSNSVNFTSDIDILKQSIVLKSILSKNLQDLSDELFSKSELYTNDEGYSPPPSVHSRPSDSTDDRVLGKVQDLNSWRSSKDLLNSQVLLSPVVKNSPQDLLPEGEPGKSSDIEDYVSEKLLEAAGRNFPMNRKSSFKKKHLVSEESSSEHVLSGSIYEYVIKQIFTAPIFSQLGIGIKSSSEARMDSQNQLLTPWERSVTSHIINYEEKDSDVNLSQSKSIISQIIQSFPVNTLLESGVIKVIELDKEHQNSLLDSQTTSSTEQYSDSRSQIKLLSRQNTSSINPLDSSVSGAEYTEDCQSISTQESKYPVRDTKSDSPNDTEEMELDSNLESSSSSLDKVKDTDTAKLKNILKNIFSIFFKYNQSERRQQPEKDSESLIKHSSSSGSEHLEKTQENFNKADKKVDRKPILNPKLRMFLEKLSETEVKNLKSELSKHIQHYLVERLTESGHITKEDLPTIYHKLYLMNEKVELKEQTPFQEKYSETVKEIMSFVNNFNHHFIDKHLETKLRGFLSEILQNYFLKNLSVSNLFNETDAMALHASMSPVRSKSELGQDIADGNFGSSLKINMQYPVTKSLQHYLQDLSENELLSLKTDLSKYLQVLFIEKLYKSGLVSERQLKGISQEIISLHSPSIPLKHIKTNLPFRNESYFMREDSEEQMKYLKNGQNAALHVLLKDKCGETELSRKKERESSFSQILKENLPAIWEQKNIYTREEETLNLIQMQSFLNKNNQANPLTRSPERPSDISLKKQKKDHGFMQFTQVEGSVYKTEIQDPYSWDSRSKTIQSKPCLEKTLKMKLLDKRENNNFYKLTAQEKLDTEFSSYLKLPNCKIPKEKEPISRLSFPTWKTNTFIHVKPEIGEQSKLDHYYQRLKGNNNNNKKHLVTFAQFKNEMETLYRNPYEACNEKRAKISESQSFKYKEKEKSSRPFFFPEVLKRENTKSKRKERDHATKPKKSFHKIVRLLPATLPTTRPHLRKSAPRNLLHWTARRTIHDCLDRFDDLHAPTVKCPKKSKSGARLLGKSPEDSHNQAKHCARPYTAPEPNKRRESAAWKFASPRMVSAGLLHLYVTPAYGIRKVRSKRKLKEDIEKRPLISEIIQMLDNAE
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MDDEKGLDLSLGLPCGGNSSSHKGKYSSSSDIKSDDGHDRGSKLINDFKNFLEGGSQQHPLNIGENFYNSFPNSSVDPEASKNSNTGGKIWPTNEIEEKRSSIGEKRKNNSVTETSQQKRQERETNRTESTDKTKVSHISITTDEGSTAENDDVADSEMDGSTSRLKGVEVLGQKNRFTVSSEKEFNVMPYGASFPSQPLNMMNMSYSQPPHSMMMHAMGSTNGERTAVQPANFPLMFGYSPVQLPALDRDNSRGVVSHHQQIHPVYPGRNSVNPDTHNDIRKLNQVISHKPTESPANGKGYGKQQVGEEGGSSSQTEGDPKVNHQVKDAAAAPDQPRAESATPSEFPAIRPGIAADLKFGGSGSYPNLPWVSTTGSGPTGRTISGVTYRYSPTQVRIVCACHGSHMSPDEFVRHAGEDNNAPDGLDASFPTGNPAASAQT
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MVCPDPPAAVSRRFPDGPASAAAARRFVRTALDGAARDLVDTAQLLVSELVTNAVLHARTEVEVSVARLEGRVRVGVGDRRPGRGLVPQRCSPYAGTGQGLVLVEQLASPFGADGGDGGKTVWFELWHDGPAPPSAGWETAVPPRPAERTVTLVDMPTALESAFRQHRHAVLRELTLAASAGDLLGVPPEDLVAANDVNNVISAGVSAAPAGPASESGLRTLPLPLSADALPAVRALRRVLDLAEARAGEERLLTLPALPRGRAFQNWLFDEIAGQLAGDRPTAWTVVPRAPEVSSAELVPWDVGQVRASRMPTVAADEGNRIVATNGAAADLLGWDPDQLVGRRLTTLVPEHLRERHTAAFTSMLLTGRTRIVGRSVPLPALHRDGRLIPVRLYIQTQETADGRTVFVAQLVPRATTFLDGPRTPGRIRKAAVGEPDGGRSPTVPPAGAGTPGARGGMSALDRLTLLAELGAQLNNTLELDEGLQRAGRLLTRRLADWCVVDLFTADARVDRACVVHRDPRALRPGAYEGLLPGVSEESRGPLARVLRGAGPLLLTGAPQPGQTGSALDRAYAGLFRELGAGSAVVAPLRARRKIFGALTLARAPRGRPFTEEDLTLVDDLVHSLALGVDNARLYQDTRSIAERLQRSLLPVLPKVEGLRLAARYAASSTTAQVGGDWYDSFVLPGGNTALVIGDVTGHDLDAAIAMSQLRSMLRGIAVDREEPPAEVLRRLDLANHSLHREATGTCVYGLIKGPPEGPWELTHSSAGHLPPLLTTRDGRTRYLDGGAGLLLGMDPDASRGTARDVLPAHSTLLLYTDGLVERRDEALDGALDRLRRHAADLAREPLDTFCDELLIGLGADSADDIAVLAVRPSPP
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MSNERPSTTSNPLAGLVAIAILLIVLGFVAGLLISRSGTPIVVPTAAPAPTNPPAPTEPASVPTPITGSMPILPTATTYQYSSPPPMSIDPAKKYTATIYTPRGEIVIELLPDIAPQTVNNFVFLARQNFYNGLTWHRVLPNFMAQGGDPRGDGTGGPGYTIPAEFTDKILFDQPGIVAMARSSDPNSAGSQFFITTAPAPRLNEQYTIFGRVIQGQEIVDGIPLRDPSNPADLATPGEMILGIAINEE
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGQEDETTRKGPWTEHEDFQLVFYVHMFGDRRWDFIAKVSGLKRTGKSCRLRWVNYLNPGLKRGKLSPHEERLVLELHSKFGNRWSKIARKLPGRTDNEIKNYWRTHLRKIAQEKKRSTTSSSSSSLSQCSSSSSRCTTVASMPVIETKERSFYDTGGVDQKLTNMKGKNNNHFKSGTTRVSDSSDGYYWMDDIWNDLGLLEDDNMKPFFDPYSEIAPSLTWDSCLSTSWTMDGQEEFAENNFHLTSQHFSSELVD
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MATPQQNQHPNPNSQSRSPEPSAPTVNQRTGQIAPLDAERNLPDRQLQSDWPHYTNRITLLFFLLHLLVAFVLTFYLAVRSIIAASSSGFQLLNWYPQLLTTAAASVIFSYPWLILTLRRPLIAIKACLSLAPFLTSAFAFILLGSSTVAGGVLGGIALFAAICMSLYGCYVAPRIDFASLIIGKSLSSAEPHAGKLVSPANPYIGISILVGILWSVFWVTGLVGGASMKHSALYLLALCVSYYWTMGALRAASVVALSRVSGIYFARGNEVGAREAFIWAHTKWFGSACLGALSEPFVCVMRLIARVANAVEQEDEFLFSCAHCCLGVTARVRTRASVWGYTHIGMHGKGFVQASEDTWVAIDARGMGPTVEGEMAGAVWWLAGVASGAGCAVLVGGWTLGVDKEIVPAVAVFAFFTGYSMTRIALALPQACVCSYYVAFLENPESPVFDETIPDRIKLFQPSFRV
The following text describes a protein:
Function:
Plays an essential role for normal photoreceptor cell maintenance and vision.
Subcellular Localization:
Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.
Sequence:
MGCTPSHSDLVNSVAKSGIQFLKKPKAIRPGCQGGSERGSIPLLVKNSTCYDAGEGLAEEQPSPRRNQTTAKGLCQLMGDPASGKRKDMEGLIPGTKTSSSQLNKSQSHMAKDIPFKTQGSHGSQGADFSGDESEESSTQDTSKWKRTAKCHTSSTQSHCYQTIHPAHEPEGKVDFPEPLVKAHQQAYTYLHSSLSKYEAILCIIHQATQTRELLQPMVSFLLLCFEEISQLLGEISKDGEVLLQEVREDLAWPLKKREPQEQPNLLQQLLQYTVSKLQVLNGTVASLTGSFLEGSSSYLHSTATHLENKLSTKRNVDERLLRALRQLESLASGCGDPGVQGLPLCSEDSGIGADNESVQSVDKLGKQTSWDLAPEPEEWKSVTSPHTEARQSGHTWQQSPFCLGSGRPQDCLLSGAPMAKVQPRAQDEARSPCLSSTSPENITSPPLKLGTSTPCDSFGIGVSVEPHLSKTSRPMDASSLSDSEDSSPEEEEEDKMSSMSLCAWQEKTPHSRPQSSPADRESPFQARTRRLRSLQAQEMILKMKESISERIKFVPVPCGHQDWSEEEEGRTVVPPRPSTVSGSRRAPERQTRSQSESCLQSHVEDPTFQELRRVQRDLSQKLEAFYALGAKGQGQSQEQILQPRAAAVWPNGTCRVSPSNTTSRLKASLTKNFSILPSQDKSILQKCNPHPEDEQGKAGKLPNAIPSGEVSEAAKATDWNVRGCPTRTSVKKLIETFSPTESLRMLGDSKDAGASPCLRNCIMPPRFPKYTGLAPLYPKPQISPASGRESLKMGIGWKPLAPIFPPLPKAEAAKSEELSCEMEGNLEHLPPPPMEVLMDKSFASLESPESSKSTENSPKETQEPGPGEAGPTRRTWASPKLRASVSPLDLLPSKSTASLTKPHSTGPGSGRSSCQPRKPALDLSSPPATSQSPEVKGGTWSQAEKATSLYRQPRKAIAWHHSGPPSGQNRTSESSLARPRQSRERSPPVGRKASPTRTHWVPQADKRRRSLPSSYRPAQPSPSAVQTPPSPPVSPRVLSPPTTKRRTSPPHQPKLPNPPPESAPAQCKVPSPPTQHPEASPPFSIPSPSPPMSPSQEHKETRDSEDSQAVIAKVSGNTHSIFCPATSSLFEAKPPLSTAHPLTPPSLPPEAGGPLGNPAECWKNSSGPWLRADSQRRAALCALNPLPFLRRTASDRQPGGRPQPPTLDPTSTSYESQLGQNSSSEESPKKDTEPGSSPCSPELQGGTRRASPPEFCVLGHGLQPEPRTGHIQDKSQPEAQPQQEEVS
The following text describes a protein:
Function:
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Sequence:
MIKENEKQSIFNSDCPNSHLADCLKWMQVYFTDLGKISKCKMPALNTTKFKHKKFCRKVWKVVGEQIKPGQTISYSDVAKLMGNPKAARAVGMAMKSNPLSIIMPCHRVVSKNGIGFYSSLNGIKTKEWLLQHEKVDTKKIGN
The following text describes a protein:
Function:
Involved in petal morphogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MSSSTNDYNDGNNNGVYPLSLYLSSLSGHQDIIHNPYNHQLKASPGHMVSAVPESLIDYMAFKSNNVVNQQGFEFPEVSKEIKKVVKKDRHSKIQTAQGIRDRRVRLSIGIARQFFDLQDMLGFDKASKTLDWLLKKSRKAIKEVVQAKNLNNDDEDFGNIGGDVEQEEEKEEDDNGDKSFVYGLSPGYGEEEVVCEATKAGIRKKKSELRNISSKGLGAKARGKAKERTKEMMAYDNPETASDITQSEIMDPFKRSIVFNEGEDMTHLFYKEPIEEFDNQESILTNMTLPTKMGQSYNQNNGILMLVDQSSSSNYNTFLPQNLDYSYDQNPFHDQTLYVVTDKNFPKGKVWIQDSFVN
The following text describes a protein:
Function:
Required for development but not growth.
Sequence:
MELFPELKNIKVPTEKSRLWKDECCYCFDTPENGEGLFIDLIGLLAFSKKYVQLNHQKTHHHLYLNFKKVAIVNEKVKSPTIENGGEEKPPKKLAIGVEGGFNVEDEEIKYEEHYKLYIFPDDKFLELSDPIIPENVRVCCEKIKTLNSQSRKEEIVSWNAESVFPSAFAESIIQLDNNTKKIDPKGPWRCDIEGCDKVENLWLNLTDGFIGCGRKYADGTGGNGHAQEHFNQTQYPISVKLGTITKDHADVYSYPEDDMVSDPLLFQHLTHWGLNPNVMVKTEKSMAELELDQNLNFEFGKIQEKGKLLENVFGPGLTGIENLGNSCYMSSVIQMIFAIDSFQTRYLKDREASFKDITQDPTQSFEIQMSKLAHGLLSGDYSIPLSKPSKNANEESEAATQIGIAPKMFKSLIGASHAEFSTMKQQDAHEYLQYLLEYIERAEHSRPSWIQQANPTRLFQFHNEDRIECGSSGQVKYTRRLENILSVPVNLDDATNKQEVAQYEETLKQQNGVRQKDQEEIRPIIPLVSCINGFVEPYRVEDFLSPATGVKTFSLNSSRMATFPEVLIIHLKKYTYNADYTPKKLNVFMDVPDIIDIDSLRGRGIKEGEVPLKEGTINTTTKVPEPSFNQEVLDTLLSMDFPLVRCKKALLATGGKDAELAMNWIFEHTEDPDIDIEQTPVNNNNNNNNSSNSNDKLFVFNSQDVDNIIGMGFTDSQAKLALKNTKGNLERAADWLFSHIDNLDELVAKDNASTSSINPSLIPQSTTSLQPVSDGVGKYELLGFISHLGNNVTCGHYVCHIKKNNRWIKFNDRHVQLSEQPPKELGYIYFYKRQLN
The following text describes a protein:
Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG); The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins; The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.
Sequence:
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWRPWRN
The following text describes a protein:
Function:
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MKPDDCLNNIHIETENLDEVDLTKLTGEAHSLSNGIVPPFTDKTFRKATSFKQKCATYVLALRPWSFSASLIPVALGTAIAYRSGGSLDLLLFVVCAVAVLAVHGAGNLVNTYYDFSKGIDHKKSDDRTLVDHILEPQDVVRFGVFLYTLGCLCAACLYFISKLKLEHLALIYFGGLSSSFLYTGGIGFKYVALGDLVILITFGPLAVMFAHAVQVGYLAVTPLLYAVPLALSTEAILHSNNTRDMESDRQAGIVTLAILVGPMFSYMLYNLLVFLPYLIFSILATRYTISMALPLLTIPLAFSLERQFRSQNFNKIPQRTAKLNLLVGLFYVFGIVLAPAGSLP
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASADMSPSRSHPHDATRSPSPRTQSPSPRDEDGSRSPGERTPSPPSRDPSPYRSPGERTPSPSPRRDRSLSPRDQPHSHPRSRSPTPRSQSPSRRSVRSPSPRQGSPARRVDRSSSPRARSPPPRRHSRSPPLRGQPPPPRHRDAGGDYRPVRKERTPTPPPVAVKTEEEKLADARAEYQKLLNLRSQGVYLPPHRLRALQAAITDKKTREYQRMAWEALKKSVNGLVNKVNTANIKFVVPELFGENLIRGRGLFCQSLLKAQHASLPFTPIYACLAAICNTKLPQVGELLVKRLVLRFRKAFKRNDKAVCLSSTMFIAHLVNNQVVHEMIAAQILLLLLAKPTDDSVEIAVGLMREVGLFLEEMSPAIAHAVFDQFRNILHEADIDRRTQYMIEVLFQVRKDKYKDNPVIKEELDLVEEEDQITHRIGLDDEIDPQDGLNVFKMDPNWEENEEEYKKLKAEILGEASDDDEDDDDDDESESGSESEDEEQKALEIKDQSNADLVNLRRTIYLSIQSSADPEEAAHKLMKLRLPAGQEAELVSMIVESCAQEKVYLKFMGLLGERFARLNRMWMDLFEESFAKYYSTIHRYETNKLRNIARFFGHLLATDAIGWHVFSVIHLNEEETTSASRIFIKILFEDLQENIGSAKLKARMSEETLQPSLQGIFPHDEPRNIRFSINYFTSIKMGYLTDEMRTFLANMPKPALPAPPADSDSESVSSYSSYSSYSSRSRSRSLTPRKDTRGRSLSRTPPRRGRGRSYSRTPSRSRSRSRSYSRSVSKSVSRSPPRRRAVESRSPSPPPRGRGRSYDRYSRSPSRSRSRTRSPAAAPPIRRGRSGTRSRSRSYSRSPSPPPARGYPTRGRAPVSNNDRAAAASGKRRREGSYSASRSPHPPPQQRLRRGSYSRSRSRSPIPIRGNGPAGRDTGRAGPAPARGGRRNRSYSRSRTRSPPPLADAATGSRRVVSRSPSPVVGNNKRRRSYSSSRSRSRSSSRSRYRSRSPVAKRGRVD
The following text describes a protein:
Function:
Could be a component of the mitochondrial translation system with a role in promoting accuracy of translational initiation.
Miscellaneous:
MISCELLANEOUS: Present with 1730 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MGFYNCRFLSRRLSVEPCRIGSAAKSYQQRSIYHFGAALTNAPSGRETPDKLRSDLHSALEMVDEIYDTNSTVEDIGNKEKGGRQKYTEEMDKAINLLKTNIKKEYRHDKYLERTKVGTYPGRRTYPGRRTYPARRTYPASRTYSDSNSYTFRINVQKIRHALVRYNQDGVQKHNQKPPRIGHGLTRVLYQPLSLQKLRDNRSRMYNFDPAVENINPEYLEKKSEKDVNTDSSGEGQSKPIFITPHKDESLLKVAKEHRKKYISSSSSMTSVLSQLHYLLSNFRRLNIIDSSISKNFPQKNCNYSESAYFPSAVILRKKRNGICSIDSDRSLDREIVLSVLGHYLEDFLTEKSLKNSSKSENYHYSSIDEFIVRSQLDAYDPNLPGTGVFDLKTRAVSAIRYDLSHVESNNNQTGYEIDKVYGEFESLEREYFELIRSALLKYSLQARIGKMDGIFVAYHNISKMFGFQYLPLDELDYIIHSSYNSKFDSLLKEKNDITKGIYGEEDYILHYDRDDRKIACLVANREFKMSMNLFSNILKHVEQLLNSSNTKWEKCKIMLKTEVEEKRSKSGRFFNEPVLNIVALPLSPEYEDKSLLVKDTSNEQLTEELLNLRSYNENLLEEHLNSLVGFKVNVKHFYHHHPNTTHLPDFALKKNDILDTESRKYISDMMKRDWYKDIPSTQTPNFFHASDVSTWEVNSTFTDINDKQILRKLYFKYLDVKLNALKNQVITRQEPDMSKKDEIMNRIKSLQARNDHRDNGSNKRYSNFGPTRLQTKLRAYAKKGALRRKLLERSNKFHI
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MRSVIVGFLLVCASTLACGELFTALTHMRGLIRLEKTLQRKLVEYLNLNPRASEDLRITMEEVKQHTKNIRGDVEKFLGHPVNAYMLIRRFIKNWKDVEEYLEKHDDQEDLLALLRLHKVDFPTSKDMLGCVQAIQRIQDVYNITAKRIASGHLSDITSTPPMSADSCFEIGYAHHRWEKHEEARQWMEESLRRLDPPFRYRGSLQKQDILEFIAWSEYMTEREDLALAHTSELLQLDPNNDFAARNLEFFLQEYQAKANGSTKKPNIFKKPPPPREHFMEAYERLCRGISYRSNEEAAKLRCYYDFTRHPMFRIRPLKVEELHSDPPIWMLRDVMYDSEIEYIKRTATPKLRRATVTNLKTGELEFADYRISKSGWLEDPRDDNEEKILNRVNRRTSIITGLDTTPRSAEALQIVNYGAAGHYEPHFDHATEAVSSILKLGIGNRIATVLYYMSDVEAGGATVFVDAEAIVKPSKGDAAFWYNLHKNGKGDERTRHAACPIIVGSKWVCNKWIHEHGQEFRRPCGLSIEE
The following text describes a protein:
Function:
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEKTQSVFIRFIVNGSLVKQILIGLVAGIVLALVSTPAAIAVGLLGSLFVGALKAVAPVLVLMLVIASIANHKKGQKTSIRPILFLYVLGTFSAALVAVVVSFIYPSTLILVAESADITPPSGIVEVLHGLLNSIIANPIHALLNANYIGILAWAVGLGIALRHAADTTKALINDMSDAVTLVVRVVIRFAPLGIFGLVASTIAATGFGALQLYAQLLVVLIGCMLLVALVVNPLIVYWKIRRNPYPLVFACLRESGVTAFFTRSSAANIPVNMEMCKKMNLNEDTYSISIPLGATINMAGAAITITVLTLAAVHTLGITVDLPTALLLSVVAAICACGASGVAGGSLLLIPLACSMFGIPNDVAMQVVGVGFIIGVLQDSAETALNSSTDVLFTAAVCQAEDAKLANPDPLAAGKSV
The following text describes a protein:
Function:
Required for gamma-tubulin complex recruitment to the microtubule organizing centers (MTOCs) (By similarity). During mitosis, modulates gamma-tubulin complex localization, spindle stability and chromosomal segregation. Necessary for gametophyte development and embryogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, phragmoplast. Nucleus envelope. Note=Reorganized from the nucleus to the prospindle and the preprophase band in late G2. After nuclear envelope breakdown, localized on spindle and phragmoplast microtubules (MTs) and on the reforming nuclear envelope of daughter cells. Present in mitotic microtubule arrays. In interphase cortical arrays, gamma-tubulin complexes are preferentially recruited to existing microtubules, from which new microtubules are efficiently nucleated.
Sequence:
MDEEASRTARESLELVFRMSNILDTGLDRHTLSVLIALCDLGVNPEALATVVKELRRESIPDSVTTTPSIH
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MLIAVPLDDTNFSENLKKAKEKGADIVELRVDQFSDTSLNYVKEKLEEVHSQGLKTILTIRSPEEGGREVKNREELFEELSPLSDYTDIELSSRGLLVKLYNITKEAGKKLIISYHNFELTPPNWIIREVLREGYRYGGIPKIAVKANSYEDVARLLCISRQVEGEKILISMGDYGKISRLAGYVFGSVITYCSLEKAFAPGQIPLEEMVELRKKFYRL
The following text describes a protein:
Function:
Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity).
Sequence:
MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAVW
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MLSSSNLNHPNVDGIGIINFLSHKYYFITGSTGFIAKVFIEKLLREVPEVQKVYLLMRAQNAEAAEQRLKTEIIDCELFKRVKDEHGERYNEFMKSKLVPVVGNFSDPGLGMDADLARLIADQLNVIVNCVGNTKWHERYDVLLDVNVRGLSKLLGYAMNCKKLRLLVQVSTAYVETRYEVIMENPIFMEERRIPEKKMPHFITRAELDIEAELEMVSNFASGIPKDKLQIEMAKFGMRRAKNLGWPNTYVLTKAMGEVVLTKFREKLPMIIIRPTLVESSLKEPFPGWIEGYRVMDPIILSYGKGQLQGITGDPLAVLDIVPVDMVVNTMMAAIANHGIVGKPGINIYHVSSSTENPLFCHKLFEYCCNYFTLHPLKDSRGELIRGVKEMEFFTTIDEYVLFGLDANKPSNVKLHSKLVRMAAIYKGTMLNPSRFSNKNSQELFGKMSKEERKVFELNMKSIDWEDYFINIHFPGLRKHILKEIFLPPKL
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MTSVSNRKCESCDEATPKYRCPRCERLSCSLPCVKRHKADHDCDGVRDKTAYVPVKEITERHLLSDYRFLEEVDRKVDNANRDVHAHKRTNNKYMNLLRSKARLSGVTLKLLPGGFTRRRQNTTQFNRKFQKMNWRVEWSFPQAEVSYSDKWVPEDMLLKTALQKYVDPEKADPIIRHRLKAYCSRELSHIHLLMKVEERRANSVRYEELHADMTLKENLRGKVVVEFPTILVVLTEQMHKYKLVTEEDTPEEESSDSSSEDESDTDTDTSSGSSDSSESSQSDEENLSSHGNGKSADQSEQQSSKHVTESRDVITSQKNPVLLENKMDEGQGNESLQVEQSDKESPEAFADSTSVTTNQIDNPETSI
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MINYLFAVALLIMQQLAAVDATAQKGMLPAFWKPLCGLSEELDSKPHKAISDLQSATSQVELMQRATLRAQIYGLAMAGTKEATPTALAELYYSSKVQASLSKLRTTSIQAAIETASAATYLKGHVDEYLSLWSNVNQGGSDGCLLTNAGSAAATITQNRLGGTECKLKLTGASSSGIQPTHITANGFPQLAHRISGDDEQHSSGKCTLASGHTNNGLGDGSALAANFKVLDGYLTIPNSANALSINSVQTMTQEHANTHPAWYNAWSKNKLPPQAEDPAFTNTTGEIKNYNLVSEAIRTVNLKKAEAADADVEAQVTSYFGGKDDAKWKEFIAKIEKFPIPAKTGKQAEPTTLGAIEDTETLLTILYHYQLQLSKRLTELQTRLDDTESKGKNKTPEQLCNEIKDAKTCNADKKCKYDETKKEEPKCTLSEEGKQKAAEKANQETEGKDEKPGTTNTTASNSFVINKAPLLLAFLLF
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MATRLRKTRRLRGGRHMGWGQVGQHRASGHKGGLGVTGMMKHHWSTTLKDEPDHYGHDSTKPPHPNITKKWASVRDLDDLFTKFGKEEGGKKVVDLENAGYEKLLGGGKVSNAYSVKVTQYTASAEEKLKAVGGEVISAAKEKSDGEEVVTEDG
The following text describes a protein:
Function:
ATP-dependent RNA helicase that unwinds RNA in a 3' to 5' direction and that plays an important role in mitochondrial mRNA editing, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA. As part of the RET2-containing gRNA-binding (RET2-GRBC) complex, acts as a scaffold for the assembly of mRNA-gRNA hybrids and the recruitment of the RNA editing core (RECC) complex. Regulates several steps of mRNA editing by the MRBC3010/GRBC6 containing gRNA-binding (MRBC3010-GRBC) complex including loading of unedited mRNA, editing in the first sequence block and subsequent editing progression across multiple sequence blocks. Also, regulates the RNA substrate content of the MRBC3010-GRBC complex as well as the association of this complex with mitoribosomes.
Subcellular Localization:
Mitochondrion.
Domain:
The DRBM domain is required for binding to guide RNAs (gRNA) and mRNAs which facilitates the association with the GRBC complex.
Sequence:
MRAIRLTVACRYLGPFRSVTLSPVVLPVRLFQTQEITPGEVSLVEATDESDRAFGETRKEDFSFDGSSEFPECFKDTKHVDTFSRARVVSFIKRFSQGAVTSSSEVFEGREIVNDNGTPLYHSRVRLPFRSHTGELWAHGVACNSKDAELLAAMHAEHIIDEFGYHIYTLPSMQRKHAEAARKAGRWAPLPDELERTQSPVRVPLPLRRIVDRDETEGGKWLLIDMRPNHYISPSHTLLSPCLFDTTAVHRIKSFLDEHKLSFAQLCTSVEEPGEGGGQSWYVATVSLPPELSTFSEIKAQGKALNREAAVTLACMHAELVLDAHSICLYPSDSTKQKQHALAAWSYGRPAPLPGEDQKNPSHVVCPLPLKQLAVRREDRISCISYEEDIIRRHRALTDQTCEFIETPTLDSSAVEQLKQFLQRENVPRTDPFLVEEVNGYYKATVVLPLPDLYGIRGGVGIAMNATDARVLAAMHAIDVLNILGFHLMDGSTARAEWIAARRARGESVPADTRDPNVLSPSGRRRVATGNSSTQTPSSSTNARSVAAAPDVGTSDPTAPQNTKRRVAKRARVADAQPTEEKDAANSDSDEATSYLKMRETVSKELWNLEPDSPDGYIMVSPTDPETRTQFEQALYSPRQVDLGSKSRIKNYLASVGRRIEEVFFVQRIEAEDNGGQAICRCAVNLPVPRRFGDRIALGEAVDPKDAENLAAMHAELILDTLGIPIYTDSALQRLHVRLCAKCGRNAPVEYSESVAAATASPPPLRREVVGSIHWENKSKRRRAAISVQKGGGPANSQETTSALREDEEPLIAPKERREYTFVPEKDLDLVSRARVHYYLRRNGIAKLEPEYRMELRGLGNVLHIAELTLPLPDVYGKRVAHGSALTKRDAEILCWMHAEQILDAVGLCLFDNLPMLQRRHVECVKRLGRWAPLVSENATKPPHTPTPLPLTLGTTQEKPQYPTPPTNVRQDWEQYAQECQRYIEINVMREHNIFYEMGKTPRTGDETYDAALAEVESMPIDPDAKTVLQRYCNVANVNYPTFWKSRTVGPISCRVCLTTIEVPGHEYLRASGVAWNKEASQRQAAMHALALLRRVEPDFAEFEKQIKAEVVDKVNLVDPAAVLDEEAPVLRRTARVSKKSLGNWDPVSKDFSHEGKVRIIELFTVCFGLQPPLVRHLNRRSGSFVQHFTVVEVTDEDGKTWVGTGRDAGPRFNEPAAFDDLFSKLSRGVQGFQALMDLIRAHPHLDPEHIANVSLTDSQKERILKAVDGLPMVEEEDVAHPEQWADADSDRGIGIMALIAMDASQRAQESQELEAKLQAKLTNEEYQTRYASQRQRLRIYEKRDEILRAISSNQIVIICGTTGCGKTTQVPQYILDDMTEKGMGGDCSIVITQPRRLSAVSIARRVAAERLESIGETCGYSIRLDAKPGRNINFCTSGVLLRLLHSAPLLNGINYLIIDEIHERDINSDFLLILLRQLLHRRKDLHVILMSATLQADQFGKYFGNAPIINVEGYVHAVEEMYLEDLVPIATERNVMTPLLKEAAAALERNGAADGFCPTVVPPTAKYGFLEATADIDYMTIQIAIDHAVRSLDLTDSSILVFLPGWDEINRAKEILERNAKFHIICLHSSVGAEEQMRCFLPAPEGKIKLILSTNIAESGVTIDDVAAVIDVGRGKEKSYVMRKGTTSVGRNEMGSMSQLVTVYASRANCVQRRGRVGRTRPGMCIRLYSKKHFQSLHDFQTPEMLRTHLDSLCLQILALDLGDPADFLQQALEPPSSDHIEAAMKRLHELGATTSTRQLTPLGLRLSRLPVAPKVGKMVIMGAILRCLDSALTIAGVSDTDVFISTREHREAVRLHKEDLSYGTQSDVIASVNAFNFWVTSHYAKTPAEVVYDLQERMLSVPQLLTVSKYKQQFFEIVAGSGFIHMKQNYKDAKNKDRADIFVDQSEYSADSLNVGLVKCVVASGLFPNVVMNRGKRLMRNKLANRLDPSSASVVHRTSQENIGQPYFVYDELVKSSESERLLVRDLTNVSLWTILLMGTSSMPVTYRDDLNLAVVDEWIMFRATFGTLELIRKFKRALNVCLGRKFMNPNDEENNAKLEELRCIIKELVCTPFKPNDLAEKPWEEKGVIIEPCTEPKGGSSEAEKTHVNSSHTPTTSAEAGGDS