lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cell membrane remodeling, perhaps acting by negative modulation of the liaFSR and liaXYZ gene clusters, thereby regulating content and localization of anionic phospholipids. Binds to the antibiotic daptomycin (DAP) and to cationic antimicrobial peptides, such as human LL-37, perhaps functioning as a sensor that activates the cell envelope stress response.
Miscellaneous:
MISCELLANEOUS: LiaX and its N-terminal region are released into the extracellular environment in daptomycin (DAP) resistant strains, such as R712.
Subcellular Localization:
Secreted, cell wall. Cell membrane. Secreted. Note=Despite lack of predicted classical secretion signals, detected in the extracellular environment.
Domain:
The N-terminal region (1-277) is able to bind the antibiotic daptomycin (DAP) and the antimicrobial peptide human LL-37, under physiologically relevant concentrations; The C-terminal region (278-533) is involved in cell membrane remodeling.
Sequence:
MKERERVLELVKKGILTSEEALILLENMATEKDEKQIEKAAEKVDTQNIGTTNKEDQVADLMNALEKGESEGPTVDSFEENTQDSAEKDRENLERILDELATKANRASAELDEVNAEIAGIKEEIKEVAEEIGTLDTKEELDALTEDEQVQRKDLHVLLAQLEEKLATQSTEKTALEEELKNIRKEQWKGQWNDTKEKVSSQFSEEWKDQATDTFNQVGGKVAEVGGQVGEFLKKTFNSFSDTMNDNVEWKDIKMKVPGVATTKFEHEFNYPNPQASLIDVKVANGTVVFKTWDQEDVKVEAKIKLYGKMAGDSPMEAFLERSDIDVDDETISFQVPNKRVKADLTFYLPKRTYDHVSVKLLNGNVLVEELTAKDVYTKSTNGTITFKKIDATMLEIEGVNGEIKVLEGTILDNIIETVNGDVSISAAPESLSVSLINGDIRITAKEKTLRRVEASSANGNIKLALPNDLGVEGQVKTNLGSINSRLTDIEVVREKKDRGNQQLHFRRVLEESMAQINASTTTGSIFLKDTDK
The following text describes a protein:
Function:
Involved in development and cell differentiation.
Sequence:
MQTNITSTKMSILVTGGTGVVGRQVVKSLELREKNINIRVGGRDQDKCNQLGFGKNSTFTRFDFMDPTTWDKSLEGVDRVFLIALPMDPTPEKSLGPFIEKCKERKLKKIVVLSVIDAERVPLVKIEQMVQGSGLTFVILRPPFFSENFSEGFMKHDIDQGTIRVPVGEHSVNWISTHDIGECASIVLMDSKFDGRTIEITGPKPINFKELSEVVSKNVGKQIRFEDIKPQEYKKCLMDRGISEPSANYLNELFTSAREDKLSKCTKGVNEITGHDPRSFEQFAKETFSNTSGSCTSKPVI
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MIQPNNIEQVLVLTLSMLTMQKAMAENEAENAIASLCHEAKYLHKVAEDFKSLLSTTDSDVSQAEKLTQIWQLKAAEATQLKEQNAYAALVLHGRLKIDKTKQARVNYKQTLSGVREGILQRISYLQGRTQAYTSFKVSKSTRDATTTKCKAKTTWAKHGDAQCDPTTLSNSPLERKTISAMAATKVKAATEAEIDIEMGNYDLELELSTALNSDSNNKCQTTTTQGTLEAITMVAKATAPHYGGKLLPTRKTDRPKQNCDAEEEKPPSKLPTADKLAALLCKAREAVPPPKIALESTTTETLFGDSDFLYIAAQLLTTEIPAGTQPEGTEADQIKQLIKSTYGDATTFGSRYTTGLYDKQTKYKKETQDSKGTLDSIATGTDLALVSSYFKGIALRLTAVQAGQEKQKNKTGQTDETCEKKGTGAECKDGCKLTGVVDNKKCVVDPDFVKKEVEGVKAENDGKTNTNTTGSNSVIIKKAPLVLAFFLR
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAISVASLASSFASLSFSSQISQKPYAVSLAHSKQFSFSLASKISTLVVSASVAEAPETEELETRENLLKLVKSRLPGGFAAQPIFGTGRRKSASARVVLQEGSGKIIINYRDAKEYLQGNPLWIQYVKTPLATLGYEASYDIFVKVEGGGLSGQAQAISLGIARALLKVSESHRKPLREEGLLTRDARVVERKKVGLKKARKRPQFSKLQVGTYSLWQHLVESDEDYYNGEYEDDYDRDPEPESDDDLSCGKAPSCRVIKKESLLAAQKEDLQRVVDLLSLKEHHARTLLIHYQWDVDKVFAIFVERGKERLFVEAGITLEEKNENPSSDPSTEYTCEICFEDFPDEQTTLMECNHRFCNDCWTEYFVVKINDGKSRRVTCMAQKCKAICDEGKIRDLVTAKDPNLAEKFDRFILESYIEDNKRVKWCPSVPHCGNAIRVEDDEYCEVECACGQQFCFNCLCELHSPCSCVMWDLWLKKCDDEAPTVNWLSEKTKHCPKCHKIVEKDGGCNLVQCICGQPFCWLCGEATGFEHTWNSIAGHTCGRYKENHLKSEEDSVEDYWRLTHYYSRYKAHIGSLKIEASESKQKILDKVHSLESKEFQLKDFSWAMSGFYRLALSRRVLACSYPFAYYYFGALFANEITKEEREIKQNLFEDQQQQLETNIERLSMFLEEPFGSYAEDKLVETRMKIITLSTVTDDLCKNLYECIDNDLLVPLQQATHTIVRYRSNGVEKASEL
The following text describes a protein:
Function:
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MPGGETVSEPQAAHSPVEKPPGTAILCHTCGNVCKGEVLRVQNKHFHIKCFVCKACGCDLAEGGFFVRQGEYICTRDYQRLYGTRCFSCDQFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKECVCQKCSLPPVAAGSSAPLSQGLWSCGGCGTEIKNGQSLVALDKHWHLGCFKCKTCGKQLNAEYISKDGLPYCEADYHSEFGIRCDGCEKYITGHVLEAGEKHYHPLCALCVRCGRMFAEGEEMYLQGSSIWHPACRQAARTEDKNKMQTQGCSQVPRGSAPHALQETRTSSESIISGPASSASGSPSRAIYAKLGDEILDYRDLAALPKNKAIYNIDRPDMISYSPYISHSVGDRQSCSEGDQDDRSYKQCRTSSPSSTGSVSLGRYTPTSRSPQHYSRPAGTLSVGTSSCLSLPQHPSPTSVFRHHYIPYFRGSESGRSTPSLSVLSDSKPPPSTYQQAPRHFHVPDTGVKDNIYRKPPIYKQHAARRSDGEDGSFDQDNRKKTSWLILKGDADTRTTSPDLDSQSLSHSSGTDRDALQTVQGDSFYSRCPYSKSDPLPGHGKNGLDHRNANLAPCGADLDASWGTREYKVRGAARAHADPAPPARQIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFREVFGMGMEEFDRLALWKRNDLKKKALLF
The following text describes a protein:
Function:
Member of the two-component regulatory system PfeR/PfeS. Activates expression of the ferric enterobactin receptor.
Subcellular Localization:
Cytoplasm.
Sequence:
MIVQPSAVAKGWPIATTLLPASCGPADPKPEPKPKQRRLCRKVFPLRARCGALAHCPIPGKNEIFTNVNHSHISIPSPRLLLVEDDPRLREDLDAHFRRRGFRVTVCGDGSHGLEAAGREAFDLVLLDIMLPGLDGLALLESLRREQATPVMLMSALGAEQDRISGFTRGADDYLPKPFSLAELDARTDALLRRVRLDRLPLAQRRDTRLVFDDQAQDVLHQGLPAGLTPSEYRLLATLREHAGEALSKPFLYRSVLHRSYTRLDRGLDVHVCNLRRKLAVVAVRHLQIQAVRGQGYLLVETEHP
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQQSQYQICVLGSANSDHFLEVEDFPKEGETIASKKSYLKNGGKGANQAVASALLKSKIIFAGQIGKDELGQLLVKEMTLAGVDLTALRKVDEQTGQAIILLNKKGENLIIIVAGANGYYETLDVLPQEYQQAIESSDLLQLQMEVPQSINILAAKYMSQNDKITVLDCGGKAEKLKSDFLEKLTIVSPNETELERILGEDLNMDADSNAEEFLTKTIHDKVFTRYPDLIVLLKLGSNGSMLVTKGYSVRCQTVTQLNPNILEEYKIVDTVGAGDCFTSAFTVSFYNSLIEFGPARISTLRKIDVETQKKLFYKAMHFGSASAFLCITKHGAMPSMPKFETVDNFIKKYFP
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MATATVESRIDELDKTRKKVLNVVEIADQILKELSNDHPSTQSVKSSTTTFASLLESIERELTQHINHLLSVTKEQQQEQVTYTQEKDCELALMRVSQIKKMVEKAIELHRSPVASTQHGDIEPMDES
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
Sequence:
MEEKQILCVGLVVLDIINVVDKYPEEDTDSRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSLAPGHVADFLVADFRQRGVDVSQVAWQSRGETPCSCCIVNNSTGSRTIVLYDTNLPDVSAMDFEKVDLTRFKWIHIEGRNVSEQVKMLQRIEQHNARQPPEQKIQVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFRSAVEALRGLYSRVRKGAVLVCAWAEEGADALGPDGRLLHSDAFSPPRVVDTLGAGDTFNASVIFSLSQGKSMQEALRFGCQVAGKKCGLQGFDGIV
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). Does not appear to play a major role in ciliogenesis.
Subcellular Localization:
Cytoplasm, perinuclear region. Midbody. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the midbody during telophase.
Sequence:
MAAPRMPPSRLSGIMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSTHAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNVASRNEESQSIVWVHAFPELFMSCLNHPDKKIVAYCSMILFTSLNAERMKDLEENLNIAINVIEAHQKHPASEWPFLIISDHFLKSPELVEAMYGKLSNQERITLLDIVIAKLVGEEQLTKDDISIFVRHAELIANSFMDQCRNVLKLTSEPHTEDKEALVTIRLLDVLCEMTSNTELLGYLQVFPGLMERVIDVLRVIHEVGKESTNIFSPSDSLKAEGDIEHMTEGFKSHLIRLIGNLCYKNKENQDKVNELDGIPLILDSSNIDDNNPFMMQWVVYAVRNLTEDNSQNQDVIAKMEEQGLADASLLKKMGFEIEKSGDKLILKSNNDIPPP
The following text describes a protein:
Function:
Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.
Sequence:
MKQYGFFVDSTKCTGCKTCQVSCKDEKNLDLGPKLRRVYEYGGGSWTQQDNIWVQNVFSYYLSIACNHCSSPTCVTGCPTGAMHKREEDGLVVVNQDLCVGCRYCEMRCPYGAPQFDAKKQLMTKCDGCYERVAQGDKPVCVDSCPQRALDFDEISVLRDKYGDENAIAPLPHAHLTQPNLVIRGHRDAKPSGDTSGRIQNPAEV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MATTLHAKLGYIEIGSLFAVQKSTLSKHQRKWHSAFATIYCSRAFNLFSLSKSKFTNTKIPRSPSYTTLTVKPDNEFEIDQTTLTDLVKDKSLNQLRELGGVEEIASALKTDAEHGIHGNGDAQDIAKRVEAFGSNTYMKPPAKGFFHFVGEAFKDLTIIILLGCAALSLGLGIKVHGLKEGWIDGGSIFLAIILVISVSAVSNYRQNRQFDKLSKVSDNVQIEAVRGGRRQQISIFDIVVGDVICLKIGDQVPADGLFLDGHSLQVDESSMTGESDHVGINQTQNPFLFSGTKVADGYARMLVTSVGMNTTWGEMMSQISRDTNEQTPLQARLNMLTSSIGKVGLVVAFLVFIVLLVRYFTGNTQDENGNQEYNGSKTKVDDILNAVVEIVAAAVTIVVVAIPEGLPLAVTLTLAYSMKRMMADKAMVRKLSACETMGSATIICTDKTGTLTMNEMKVTKFWLGEEPVAEEAFSSISPYVLNLIQEGVALNTTGSVYRPSSVSEIEISGSPTEKAILSWAVHGSKMDMQKVVKSCSILYVEAFNSQKKRSGVLMKRKADNNTIQAHWKGAAEMILAMCTSYYNASGLVINMDDNAKMRFEQIIQGMAASSLRCIAFAHKEIPAEEQVDEQEHRALLKEDGLTLLGLVGLKDPCRPGVKKAVEDCQYAGVNVKMITGDNVFTAKAIATECGILKPNQDMFSGAVVEGVQFRTYTPEERMLKVDKICVMARSSPFDKLLMVQCLKQKGHVVAVTGDGTNDAPALKEADIGLSMGIQGTEVAKESSDIVIMDDNFASVATVLKWGRCVYNNIQKFIQFQLTVNVAALVINFVAAVSAGEVPLTAVQLLWVNLIMDTLGALALATEKPTKELMEKKPVGRTEPLITNIMWRNLLPQALYQIAILLTLQFRGKSIFGVDDKVKDTLIFNTFVLCQVFNEFNARKLEKKNVFKGIHTNKLFLGIIAVTILLQVVMVEFLKKFADTERLNWGQWGACIGIAAVSWPIGWVVKSIPVPEKPIFSYLKMKKHKKNSS
The following text describes a protein:
Function:
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. MSRB family specifically reduces the MetSO R-enantiomer.
Sequence:
MTAAADSVQKTEEEWRAILSPEQFRILRQKGTEPRGTGEYNKLYADGFYNCAGCGTALYKSVTKFDSGCGWPAFYEGLPGAINRSPDPDGRRTEITCAACGGHMGHVFKGEGFKTPTDERHCVNSVSIKFIPGDAPASS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MGDFPPPERTSVKASELVHRAVDRSYEDFRTLMHQLPTMREEERREPLLAHLQSSRKRFAQLLAVLKWSVQSPLLQQCDTLLQQTESYRNNVNETNDRLFFMHADLNRAKERRYDLSTAVDVLYGGSYLRLPTIINNAMFPRELPEVDTEQAATEVADIIRFRLIEAEIPEQLSNIKLEGGFVTCQAEGEFEIVLTIQGKEKDAKWRVISVNTVLTDPQAFEDHAQAASTSVLRIIRTNAPNAAHYNHLKNLVQRAMNKSEKPFVDAFNVMREFCSSLALQILASQGKLLMEGRWKNRIMIKHHRDQYVLDICYWPKACTRKEAQPLTEQQRLLQQLSDPVANSQKGSSLPYPESSLCVRLGFDPNQKKLLSVSLSPSLPPNLPGYTSLLSALEVPSNMFLLSAENLLIAAMRAHVSAALFSVGRLLVVDSPDDKASTQLVSGEDVSMICSDTSLRIARADIGGLQQFLEVTFDIREGQFIVSSVAAAKHPALYATVKQLERILNAQCKVELGGNIDKSFPNDFALVSGNGKGEKSNELIHASVRKALCEIVADEVAQIGSSFKGIEVLRSVNLNWERYLAFRQQHGGQTEDLSISETALYFQLTSSKESTCYLVIEIDKYGEVDGMNGNVHEAAEVEEYVRLPCFSLLQTSAGLPGQPSGVQFIQRFGAFKKEDLHPSVTRHNEIIANDLRGSRKRPYGSNGNSLVGNNVRSTKKALLDGGRVQENTGYWLDDAEHNAVSRNFVPHIASVLLHAITLCSERIQLQHFVNFARRRKSRIRYSGEAGTSNREGTGGQVVTLSFPEKVNTDPLKIVAIQGHLKHGGGFELCLQLSSLPFKFILPKDPKQHLLSERSHYVNARGQLIFKYPTTLVTSDLFSENPLEMFMVELICVVRPLCELAVKLEKMLTSVGRYTNDIKSDGHFYVESADPFAIVLACRAPNPRHCIAAGSSPDGMTTYRVTVQFKQKMGFVVNYSHKAEHPLMHFIQSALNGHSDPAQFVEALERTCIPMGILASVVESQLLCAKYYRQDPPPNAKDSAANGGPKAVGRGKMGGKGMKLGYKFKLPGEEKGYYAEKSYGGDDKSFVPAELVMIPRSQTQVRLSYGDRSAVDIYFLENHSVKMQSSTGGVRVPSCPSEKGIVMDCQNFADKLRSALSEMASA
The following text describes a protein:
Function:
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.
Sequence:
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNLMTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDYLLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGSEDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYNRFQELIQEYEDSVDPPMRLPEQPGAGKPENEEKGGRGAPGGGEEPPRSRAPDFPTWQVFSPKPLPEKQAFSNVYSGLDCFQPAGRGWCGGREPLCQMSGRWGEGEETPWTRRPGRGPPGMHIPLGQRFGDLS
The following text describes a protein:
Function:
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MEAVLQRLQTLTPDELRVQLRAAGLQSGPVTHTTRSLWEKRLARALLEERTDSHTPHSSGALPADEPEQPISVQETQEAREESSETSTEGPSVYYGVCANPDEPSLLTGSPLVFVDQTKVLKAVMKLKDARFKAFASRAEAENFAKGLCGGRVSPEKPSTASVTDVEKANEFRSPRTQDLTATLRRTVETGDQQAFRELVWTNPRFLIGSGDNPTVLQEGCRYNVLHVAAKENQAGMARLLLETLEDPEFMKLMYPQDQENMLSQRIRYIVDLYLNTPDRASNETPLHFACKFGCPEVVNVLCSHPFIDKHCRNKYDQQPSSVICERKNRSKDVKQKILQYLEDRFYVPLLRAEDNTLPPVIGAPWCPGAQESCDQSLEQDRVMDSPKNPIMTIRAFVGPLSSAKAEEFQRRWKTPPREQAQYFHQILKSDAERGAERVGRELAHQMGYTWAEHWAFLNAFTDLSSRDGLKMLEEHLSSGNPPRTHCPAAHTGAAGDAGAVRLPVCDLLQEFEKVLQCGDQTDGESEDEELFFTADEDSDDAGGSWICRRVEQDPSISSSVSSSCSSFKSTHSTTTERDAADVFITGPSPSRLDHEVLVALNDVQIDLHLYPTVSRWRNRVVSYSPSQRQSWPAVSVLTPEQWSSTADRLNMLSGSPRLRRPPHCDHQLLMFSPTNKTYRHI
The following text describes a protein:
Function:
Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate.
Sequence:
MSEDTRVKIQVFRPTWEEFKDFPKYIEYIESQGAHKAGLAKIIPPPEWKPRKSGYDLDSLDITIPSPICQVVAGKQGLYQQINIQKNPLTVKQFAELANTERYATPKHFDFEDLERKYWKNITYVAPIYGADVCGSITDKDCNIWNINHLGTILDFVDEDYGISIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAPKTWYAVPPEHGRKLEKLARNSFPASHKTCPAFLRHKMTLISPQILKQHNIPYDKITQEENEIMITFPFGYHAGFNHGFNCAESTNFAMPRWIEYGKRAAQCYCSSEMVKILMDTFVKRFQPDRYEAWMDGTDFGPHPEDPTTILGPPPRILDASGDERDEGIEDGGPATAAAAAAPLKKGCNLTVSIRNVSFKEKNPDLDLTDIQQNPHLPDDVKQALYGIADEEEPPKPAKSFKQSSYDPFDDEDEEEEDEYLERRKKAGKKRKKVDSDYDDDWYSTTHAKSKGRKSGTPKKRDDTPLDTEKRERQLAAKRLNINKKRQEQRLEKERLQQQQQRLEKERLQQQLLLRRQQQNRPTNGKSSNGMIDRQKAMPRTIPPDPLRIETSSNRGGAAAPVGRVCVLKAPFYHRRAASLDEVDPLSVRARQSLPSIKAPKPTPMIGKPAERKSLPDTFLSDVAKRYPELEIRPAKDYLLTSVGCKQEKLSIPSKAVAAKPRSVTKSIQAATSLLLPIGKRPPQGRKSLPAVPSASSAPVATTVSSSAAAAGSTSVPTNSTPKPKSTTKRRKSTPAVSAKPVVYETALKKPSPDLFDNSKDFFTVFNQFVAGDQMQVTTTHHPVMDKPVSSVATVPVPTKTSSLPVAGPLWNNKVRPLLVNSTSQIVRAASAALQMPTPPASSTPIQTLKSTEIAATCVNYVAQPRQVPVAPVNSIPSPSSSSTNGTVGGEMAENQRAAAATQQTAADSTVLLLHNGNQLNVMDRTILKVPKPPQPPPITIPVVASDGISPNSNGTSQPSSNVINVLIINGTDVSTVTPYTIDTPPLLQDGQLTPIASSTLVQPTACVSDTLIQTNSTCS
The following text describes a protein:
Function:
Hydrolyzes certain amino acid conjugates of the plant growth regulator indole-3-acetic acid (IAA).
Sequence:
MAWFSAHLVALFLLLLSHLATPSSATTTRLGADLLGAARAPPFESWLRGLRRRIHQRPELAFQEHRTSELVRAELDTLGIPYVWPVAQTGVVATIIGGGGGSGPVVALRADMDALPLQELVDWEYKSLESGKMHACGHDAHVTMLLGAAKLLQSRKEDLKGTVKLVFQPAEEGYAGAYYILKEGVLDAVDPVIAASSAILSLQQLVARETDPLESAVVSVTQLRGGDAYNVIPESASFGGTFRSMTDEGLSYLMKRVKEIIEAQAAVHRCTAIVDFMEEKLKHYPATVNDEGMYDHSKEVAEAMLGEANVKVAPRSMGGEDFAFYAQRAAGAFFFIGVGNETTMDMVRPVHSPHFVLDEDVLPIGAAFHAAVAIEYLC
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MSLVKLANTCAHLQNCSKVRVALTSIPYTKLQLQFAYNLYQQGFLSSLQKGSTMGPDKDFVEVTPDNISTRRLWVGLKYRDNKPVLSSCKLISKPNSRIHLPMEDMKKLCSGVTIRNIKPLQPGELILVRAHNNIMDINEAISKKLDGEVLCRVK
The following text describes a protein:
Function:
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Sequence:
VESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
The following text describes a protein:
Function:
Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The di-lysine motif confers endoplasmic reticulum localization.
Sequence:
MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRHYLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRKEKLKKME
The following text describes a protein:
Function:
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MERFLFFWMCSFYRAVLLLFGTLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVVETITDLTVAWFPLYYELKIAFVIWLLSPYTRGASLIYRKCLHPLLSSREREIDDYIVQAKERSYETMVNFGKQGLSIAATAAVTAAVRGQGAITEKLRSLSMHDLSQIGQQDEGGNQLFQYSSRSANPAARRAQSSEHAADGTYTHDRSDEEAEPTFSEDEAVSQKGLRRSQSVKMTRSRARKDARYGSLKIKGKKRPALSAVNYSTMRDTPS
The following text describes a protein:
Function:
May be implicated in B-cell differentiation and lymphomagenesis.
Subcellular Localization:
Cytoplasm. Note=Seems not to be secreted.
Sequence:
MKLSCTLTQWALYVCPAVLLATQMLLAASSETLKCEGLVSTEQGSCQAAAEEDEGDEDDGDMTQSSEAGFQFKGYTFSKPFHLSVSYDWLILQGPATLIFEGDTLVLHCRAWQDWPLTQVIFYREGSALGPPGPKSEFSITMVQKSDGGHYHCSGIFRSPGPGSREAASPVAITVQELFAAPVLKALPSSEPQEGGSVTLSCQTKLALQRSASRLLFSFYKDGRSLSVRGVSSELKIPKASEEHSGSYWCEAVTEDRQISKQSPQLEIWVQALQKPTASETPPTEALGPLPPPPASSAEQPRFSSPDPHLHHQMQLLLKQIQDVRALLGHLVMELRDLSVYLKPGTTKVADK
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MLLLLRLLLLLLLLLRAVAKRRDPHWNRTWDCTNPNLEGLLDYQKKICIKNLDLMSGVVHASLQTAQTCQELFIDSRWNCSNILQAPRYMPDLTGGSREQAVVYALASASLVQSIAKTCSSGYSTKCSCGRHPFDEPPATDFKWGGCGDDVRFSVDFSHKFTDKFWQKKLKEKKLKKLAMINLHNNRVGRQIMSTSLGTSCKCHGVSGSCSVKTCWKSLPDLKTIGALLVHQYAIAVEVDLRRPRVKNDDVTVGGKRGGRSGDKQQQQMSNSFWLDHEEKWIDFDYGGEEALIMAMNNNNNNNNNNNQNGINNINANNNNNNHMNNDYNEYDYGVDVRVMKAKSAPPSPPSLSNKKNNKNNKNKNNKNKKDVKKVLVPILPFRKNFSENDLLFITKSPDYCLPEPSLGSIGTKGRECSRTEDGSGGCKSMCCGRGFTSEEVEIQYRCDCKYYWCCYVKCKTCYKVVEINRCR