lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
Sequence:
MDDRALLAKLATGRLSGDTLAREAGLTRAAVWKRIQNLRAAGVAIDGQAGEGYQLAAPLDLLDAQRIRAALQADAAAGLAALELAWTVDSTNTSLLARPAPEQGVAVLLAERQTGGRGRRGRQWASPLGAHLYLSASRRFSGGLGQLAGLSLAVGVAVAEALRGCGFNEVGLKWPNDLLARGRKLGGLLIEGGGEMAGNARAVIGLGLNVHMPPAAAASIDQPWVDLDTLAGRPVSRDQMVAAVLSGLIPALALFEAQGLAPFLSRYAALDLLSGRAVQVEEAGSLHRGTALGLAADGALRVQIGSDVRLFHSGEVSVRPA
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MVIDLTFSDSDDPDAPTKPTQKRLRQTTIEASLRGNPRTGVDARAAAQENGGPGTAEHTGAQHAYQDADAGTPARPNQRRRVDDGAGPSHLGPGGAANPVTPAHQRVPAAGGAAGSPGPGPSRSTQPAAPLPGTRPRARAPPPPLPAGTEPPQATAQAQTPQGPHGRQAQPGIPAEGDAAAAGAGASTAGPGGGAQGTRRRATANGTGGAAQGAGAAGGAAGGGAAGGAAGAGAAGGVAEGAAGPAAGVAATPEAQRHSTWRALHTQEAKLARHREALAGTDADSSLCFLQLAQQANHTLQAIQDPAMAARDAAQHHLLTDAALQASARLERAHGSRTPKDLVDAILFLYAPRREPGAAGAGGAAGAVVDWARLGWDTEPLRRPARGASVMLGPLDVMPKERKAPAARRPRDKVAEVTRAQELQEAQDGSGHDSFTSKIMEEMLTALRRVRDQATAAAGAAGAAGPAGAAAGGGSGSGSGSGSGSGSGSGGRSRGSGAAGAGELVQAPCGLRVPLGAFRPYREVVLDHAGFAQTVENASGADHLFTQEALLIYFDEREDALDNILLAAFSREEMAAMRAARKRGSATVASGQARIGAAGGAGGSSAPPAAAAARNQEISHMLVSYSMDLWRSWCERTPPEACLMRSRPSAPNPDALDAEGWAGGGAAAGAGGGAGGQRGMGAGGRGGRGRAAGGAGPSGSGGGGRRGPH
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MSQIKIELIKSINDLNSRGLLLSSKWSSEQLNGLSPTILATPLTNEEQLSIISQPSISSPPIGSNEYYKYILAKNYFDLKEYRRCSDVLIDCNKYQLPIFLRSYATYLAIEKRREEDIIEQQAQQQQQQQQAQQQAQQAQQESQQNDKNNDTNNNNKTDQQQQQQQQQKIEQCQEFKQLFQFYKKLYIENKKDMDGFLLYFYSMLLKKQRDFTMARKVLIESVHKYPCNWSAWSDLSSLCSDSADIIMQLSLPDHFMKDFFLAHFKLELQQNNESLVIYQQLSRTLFTQSTYILAQTAIGNYNLRAYDIGEELFERLIELEPNRLENIDIYSNILYVRDKKASLSMLAHKAMKIEKYCPETCCIIGNYYSLKLEHDKAILYFQRALKLNDRYLSAWTLIGHEFLEIKNVSAAINAYRKAVDINPRDYRAWYGLGQTYQLLKLPLYSLYYFKKATTLRPYDPRMWCAAGGCYEFIERIPEAIKCYERAEENYDRERVAINKLAKLYQEIQNNEKAAFYYKKNLYYCDQEKIDGQEIIDALLFLANFYKNQNQTQSEQYCLRLLDYAGPEKEEAKSILREIHSKSKLSSKSKPK
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MADEEVTLLDFCASMYGMRCRAALAEKGDEHKSKEEHSVNKSELLLQLNPIHKKIPVLIHNGKPVCESLVIVELWTMKGEEQDAAKKEFIECLKLVESELGDRAFFGGEKFGFLDIAIIGFYCWFSTYETCGDFSIEAEYPELAAWGKRCLEKESASKALTDPRKSCAFILESKNARGKE
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Subcellular Localization:
Cytoplasm.
Sequence:
MQDVIFFDQRPRPDRDQTPRERRYYVWTVGCQMNISDSERLEAALQGVGYSPATRPEDASFIVLNSCSVRASAEERILGKLGELVRVKRQHPDTRIVLWGCMVGPNNRSIFADQLPMVDHFVSPSAVDEVVALAPNPIYTLDEPALPVRDWSHPPVSVHVPIQYGCNMTCSYCVIPLRRGRERSRPLAEIVEEVRRIVARGAKEITLLGQIVDSWGHDLPGRPELADLLEAVDPTPGLLRLRFLTSHPAWMTDRLIETVARLPRCQPEINLPVQAGSDRVLKLMRRGYTVARYKTLIARIRAAIPDISLTTDIIVGHPGETEDDFRQTMDLCAEIGFDKVHIAAFSARPGTRAAEQEQDPALAVPPAVKEERRRRLEQLQEQIATERMARFLGQTVEVLVEGESKGKWRGRTPGNRLVFFSHPADLTGQLVPVKITATSPWSLQGVPQLDDSVNAQSKENGLVKAR
The following text describes a protein:
Function:
Part of a signaling pathway that initiates the aggregation and leads to the formation of aggregation centers or streams. Not essential for cytokinesis, pinocytosis or phagocytosis. Not essential for development, except in starvation-induced aggregation.
Sequence:
MEEIQKLINELGGSQYKDKDTEHYSEEAVELLIKKIDNKSKGKTVIESNTLIYKTLADWSKVEDNRETIIRSPSNVIEKTFQLFEFLLPNGVETLNTDTTVEQSELFSMVCRLLGNLTYENAPNREFIFDKTPSILKYISSFVSQTKYQSLQRTSCAAIANLSSETDFIQLEFFKLGVVSILIDLICREGTTDEVNQMAIKAFNNLVDNENTQVDIHFKEIHRLLGQLKKSLNKEGYYENSFANDLVSSLSTLSLNKDLQKEILKEGFLNDLIELIEESNVHREMINQFEDDDIEKDKDISIAPSTSELIFKLADNDDYRQYFYNKERDGNDANNILDRMIKIMTSPPPAYKDGDSKAQLKALDVAKVKKNITKTIALCSLEDDVIDKFIKTPKIFVDLLVDTEDTERIVNGEMIIGNLARSEPNCRLLNSYNVIELIADIMKKFPNFQPIQHLGLSSIRNLTLPTINKGFKPSSTLMEDVVFNSKVHNQVIQFAALSLIKNFIGCDQSNLKLFLEFPNALQSLLDLANGRVPASMDDESDQQEQLQLDDAKIQEIEEKFEEKEKTIEKTDEKTDEKTNEKKQSKKDMRVIYEATRLLLRFLDNSELSNHQEKMKQLIEESVEPFFSLLQSPFPILQVEGAKGLVLLIKHDKQLFLSRPSWVKDLVEVLSLSIIPFQQLSREQSTITTDPNHQKLIAQIQSNCNFSTELQNVILSNIFYNFSLDESICKKMKDQNVISELKTLKSKQDAPQSLTNLIQKILVQLTI
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Together with psd1 and psd3, responsible for the majority of phosphatidylethanolamine synthesis. Plays a role in lipid droplet biogenesis at the endoplasmic reticulum membrane.
Subcellular Localization:
[Phosphatidylserine decarboxylase 2 beta chain]: Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. Nucleus envelope; [Phosphatidylserine decarboxylase 2 alpha chain]: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Nucleus envelope. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain; Lipid droplet. Endoplasmic reticulum membrane.
Sequence:
MRPRQRFRRFHPRWSKVNLRGFGGVGALKGVKALNGMNVRVSMRLKWISNRIHRIRRSRRLGRLSISVRPNGSWQVYLLSSLPLRSLSRVWGQFNRAHLPTFLRTPGFKLYAWVFGCNLSELKDPDLTHYRNFQDFFCRELRPETRPVDPVSPVVSPVDGRIVCQGVVDNNRIQHVKGLSYSLEALLGGISSSNPLVVNFEDEITPDLIQKHEQFAEQHSISLNSNNRYRKADASAAVVDEHSDEEALLCAFTDHPHFYLNDSRNSLNYFCPFSAFEDISNSVRSSCGKRLSPSSNFDLNNLGGDDDLRSESSSDFESAPASILEHEPTNWDDWVQEADVTDIDSLPWHNIRPGNKLFYSVIYLAPGDYHRFHSPADWVIESRRHFSGELFSVSPFLARRLHNLFVLNERVALLGRYEHGFMSMIPVGATNVGSIVINCDPTLSTNRLVLRKKSLGTFQEAVYKNASPVLDGMPVSRGEQVGGFQLGSTVVLVFEAPADFEFSTYQGQYVRVGEAL
The following text describes a protein:
Function:
Plays an important role in intracellular trafficking of seed storage proteins to the protein storage vacuoles (PSVs). Participates in the transport of the proglutelins from the Golgi apparatus to the PSVs in endosperm. Functions cooperatively with VPS9A to regulate post-Golgi dense vesicle-mediated transport of storage proteins to the type II protein bodies (PBII) protein storage vacuoles in developing endosperm. Involved in the maintenance of the general structural organization of the endomembrane system in developing endosperm. Binds GTP in vitro. Forms a quaternary complex with the two glutelin zipcode RNA-binding proteins RBP-L and RBP-P, and the membrane trafficking factor NSF. This quaternay complex carries glutelin mRNAs for active transport on endosomes to the cortical endoplasmic reticulum membrane, and enables endosome-mediated glutelin mRNA transport in endosperm cells.
Subcellular Localization:
Prevacuolar compartment membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Protein storage vacuole membrane; Lipid-anchor.
Sequence:
MAANPGNKIRNAKLVLLGDVGTGKSSLVLRFVKGQFVEFQESTIGAAFFSQTLAVNDETVKFEIWDTAGQERYHSLAPMYYRGAAAAIVVYDITNAASFTRAKKWVQELQAQGNPNTIMALAGNKADMVEARQVPAEEAKTYAQENGLFFMETSAKTAINVNDVFHEIAKRLLQGQQAQDTPAGMVLNQRPAERMVSSSSCCS
The following text describes a protein:
Function:
May be involved in neuronal differentiation.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear.
Sequence:
MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGGGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLARDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEPKLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKLASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRAPGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPRAPLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAESQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA
The following text describes a protein:
Function:
Protein of the nuclear speckles that regulates RNA exosomal degradation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MSHSKKSLFAAYSNDDDGDGDGDDLYLEEHQKVTSTNTPSSSWFSNSSYKEKQENVIDTVTSKTQLKRASDFFNLDSDNTFSSPPPPSSSPPLYSKTEKKNNDKVKIIMKKRSFIDSSSDDNSDDDDNDSSSSDQDSSDDDSGGFTYNRKKYKKEQQQQENEENEENERKNRKKEKKKKRKDKKFKNDDKSMMIISNENSENYSDNSSYFIEKTGDKVFSSRTSTPNYNYDNSFILGMSDYKIGFSKKEGYQIEPISLTSFNKQQINNRYFTKPSSSSSSSSQSQQQLITVITKRKEIEEIEKVKPISNIKDPSKSNDDEIKLIVLNENNHDNDDDDNDDDDNETLERKTLKKNSELNKLVEQYPNNIEYWIDLVKFQENFQQFSRNVNKSKTSMYEKQLSIYRNSLLHNPDSEILTIEYLKLASKLWDQQKVLDLWNKVLSSSSSSSSSSIISEKLWKEYIEFCLSNFNDFKIEKIKETIITIIRKMLVKRRSFKVKDYNFMENISNLEESILQFISQLSKLLNQAGFSERVIGIYQSLIEFNCFEPIQLSNETQATLLKEFKSYWSSLDYPKIGNPNSIGWSKSFTILLNNSINNNNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNMDLDNLDNLSIEEIEKLLKEQEDQENQDNENIFNITHKSKDLNEDDDNENNNNNQEEQEDNDSNSNDNDNNNNKFNTWGKKEIELDELKWKPLDINNNLEVNKEVNENDTERVVLFNDFYELLFRFVKEENKLELVFQFLEFLGVPISLLDDKIQPRYSFYHPQRRDSINSIHNENIISLLFKDLKQQPSPPSPSPEYPNWFKTFDKFSNNNNNSQNLLGLSDDKIKFIDSIYKLILENSNGIKLKEKLYVSYIMFKASIDINDAKVYTKSLCEKFKNLIYFDIFASLELKSGKTQQARTIYQTTCFYINQLINQQAQQQQQQLQIDLVYREYLFMELNLIYQTIEKDPQILKRFIKSNHKPIELFFTPLHILQCYLDGNYKQYSSSTFNLNTINQFLNQLNLKFLQKLQQQQQQQQQNSSSSSSSSSSSSSSSSSSSSSVDFLLCYCIFELLSNGFDGFLILFKRITSSSTNDYLKIFSIQHELLTIRCIDMVTKIAPLIGTDPKRIKNLIIDSLNQYYDHPKLLSLFLNWESKNQLINRIRIYFDLNSINNINNNNGGDDGGSSIFWLFAIKFESNRIGAAQRIKSLFEKAISTTQKHNIIFWKLYIEFEINRGRLKIAKSIYYRSIKQLPFSKQIWLLPFTNSKLSLIFNNQEFNEIINLINEKGIRLRILTPKVSN
The following text describes a protein:
Function:
Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Shows a strict specificity for acidic residues (Asp or Glu) in the P1 position, and has probably a hydrophobic residue preference at the P2 position. Preferentially cleaves the synthetic substrate Leu-Asp-methylcoumaryl-7-amide (Leu-Asp-MCA) as compared to Leu-Glu-MCA.
Sequence:
MKRFFKMALFLGVSALYGQQGGMWIPSLLEGMNAKEMKTLGMKMTVADIYSVNKSSLKDAAPHFNGGCSSEVISDKGLLLTNHHCGYGQIQAHSTLQNDYLANGFWAKSLAEELPNKNLKVTFMVRIDDVTKQVLKGTESITDETEKAKLIEKNIAEVIKTAPKEAWQENSVKAFYDGNQYILFVTETFKDVRLVGAPPSSIGKFGSDTDNWVWPRHTGDFSLFRIYADKNNRPAEYSKDNVPYKPKHFFPISLKGVKEGDFVLVFGYPGTTQEYLPSAAVAQIENVINPARIGIRDIVLKVQDSYMRKDQGIKIKYAAKYARVANYWKKWMGETKGLKKSGAVALKQQQEAKFQQAIQKANKQAQYGNLLSDFNRLYKEIEPYTLAANLNSEFIFRNIDLLSNGSRLLQLEKALEDKGEQSFNDRKKNLLNTFKEIFKDNDKQVDKDVFEKVVVFYAANMPKNLLINSLKNFDAKKLADNLYNNSFLTSLSGVESVLNLSAAEFKERMKNDVGIQFVRELKEMNDTQVFPVYDRLNTQIHALQRTYMKAILEFSKPSDRIFPDANGTLRVTYGKVAGFSPADAVTYSAHTTLDGVMEKYVPGDYEFDVPQHLRDLQAKKDFGRYGDKNGKMPLCFLSTCHTTGGNSGSPAIDANGNLIGLNFDRVWEGTMSDIHYDPKLCRNIMVDIRYVLFVIDKYAGAGHLVNEMKLIK
The following text describes a protein:
Function:
Modulates root tip growth. May play a common role in the tip growth of plant cells.
Sequence:
MSTTEPSPENDRDPQPTTISTPTSTNAKLLKKIPAIPFRHSDKEGEDEQAKTDEVTTELAGEGPMSHDSPEILAPSSLGLNHIRTKSSPAPSPLRFSSATPLISPGQDDKDVAKEKPRVGVVDARADARARWPIPPHQPDQGKKVQWSQSKSQRVPANSNPGVESTHVGLAKETQSPRFQAILRVTSGRKKKAHDIKSFSHELNSKGVRPFPVWRSRAVGHMEEIMAAIRTKFDKQKEDVDADLGVFAGYLVTTLESTPESNKELRVGLEDLLVEARQCATMPASEFWLKCEGIVQKLDDKRQELPMGGLKQAHNRLLFILTRCNRLVQFRKESGYVEEHILGMHQLSDLGVYPEQMVEISRQQDLLREKEIQKINEKQNLAGKQDDQNSNSGADGVEVNTARSTDSTSSNFRMSSWKKLPSAAEKNRSLNNTPKAKGESKIQPKVYGDENAENLHSPSGQPASADRSALWGFWADHQCVTYDNSMICRICEVEIPVVHVEEHSRICTIADRCDLKGINVNLRLERVAESLEKILESWTPKSSVTPRAVADSARLSNSSRQEDLDEISQRCSDDMLDCVPRSQNTFSLDELNILNEMSMTNGTKDSSAGSLTPPSPATPRNSQVDLLLSGRKTISELENYQQINKLLDIARSVANVNVCGYSSLDFMIEQLDELKYVIQDRKADALVVETFGRRIEKLLQEKYIELCGLIDDEKVDSSNAMPDEESSADEDTVRSLRASPLNPRAKDRTSIEDFEIIKPISRGAFGRVFLAKKRATGDLFAIKVLKKADMIRKNAVESILAERNILISVRNPFVVRFFYSFTCRENLYLVMEYLNGGDLFSLLRNLGCLDEDMARIYIAEVVLALEYLHSVNIIHRDLKPDNLLINQDGHIKLTDFGLSKVGLINSTDDLSGESSLGNSGFFAEDGSKAQHSQGKDSRKKHAVVGTPDYLAPEILLGMGHGKTADWWSVGVILFEVLVGIPPFNAETPQQIFENIINRDIPWPNVPEEISYEAHDLINKLLTENPVQRLGATGAGEVKQHHFFKDINWDTLARQKAMFVPSAEPQDTSYFMSRYIWNPEDENVHGGSDFDDLTDTCSSSSFNTQEEDGDECGSLAEFGNGPNLAVKYSFSNFSFKNLSQLASINYDLVLKNAKESVEASNQSAPRPET
The following text describes a protein:
Function:
Contributes to dephosphorylation of tyrosine 15 of cdc2.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFKEVSTENGVLTPLITIKEKAYMIIEGLNEEEIELLNTRLPKLSKKALARNRYSNIVPYENTRVRLDPMWKEACDYINASIVKIPSGKTFIATQGPTSNSIDVFWKMVWQSVPKSGIIVMLTKLRERHRLKCDIYWPVELFETLNIGDLSVILVKVYTLTSLNEVQVREFELNKDGVKKKILHFYYNGWPDFGAPHTFSLLSLTRYIKSLSYSPDFETAPIIVHCSAGCGRTGTFMALFEILSQTDDSTSTSKFEVDNIANIVSSLRSQRMQSVQSVDQLVFLYTVSQELLQGKEFLLPQL
The following text describes a protein:
Function:
Cytokine which acts as a ligand for wgn. Also acts as a ligand for grnd. Induces apoptosis by triggering JNK signaling. Together with grnd, involved in egr-dependent apoptosis in wing imaginal discs during development. Required for JNK-dependent non-autonomous apoptosis through release from apoptotic cells and activation of apoptosis in neighboring cells. Required for JNK-independent damage-induced apoptosis in the embryonic central nervous system through regulation of the pro-apoptotic gene hid. Involved in the innate immune response to extracellular pathogens. Plays a role in the melanization immune response through its involvement in the rupture of crystal cells and subsequent release of prophenoloxidase. Following UV-induced epidermal damage, released from apoptotic epidermal cells, binds to the wgn receptor on nociceptive sensory neurons and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious. Involved in glial cell division induced by neuronal programmed cell death and injury. Has tumor suppressor activity and eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity. Under certain conditions can have tumor promoting properties by inducing cell proliferation and invasive spread. In the gut, involved in stress-induced stimulation of intestinal stem cell proliferation; produced in intestinal stem cells and enteroblasts to activate JNK signaling in enterocytes through interaction with its receptor grnd/grindelwald. Involved in regulation of insulin production in response to dietary protein shortage keeping systemic growth in check. Shed from fat body cells into the hemolymph in response to dietary amino acid shortage and activates the JNK siganling pathway in brain insulin producing cells by binding its receptor grnd, leading to inhibition of insulin production.
Miscellaneous:
MISCELLANEOUS: Named 'eiger' in memory of mountaineers killed climbing the Nordwand or 'wall of death' on the Eiger mountain in Switzerland.
Subcellular Localization:
[Protein eiger, membrane form]: Cell membrane; Single-pass type II membrane protein; [Protein eiger, soluble form]: Secreted. Cytoplasmic vesicle. Note=internalized into intracellular vesicles upon binding grnd.
Sequence:
MTAETLKPFITPTSANDDGFPAKATSTATAQRRTRQLIPLVLGFIGLGLVVAILALTIWQTTRVSHLDKELKSLKRVVDNLQQRLGINYLDEFDEFQKEYENALIDYPKKVDGLTDEEDDDDGDGLDSIADDEDDDVSYSSVDDVGADYEDYTDMLNKLNNAHTGTTPTSETTAEGEGETDSASSASNDDNVFDDFTSYNAHKKKQERKSRSIADVRNEEQNIQGNHTELQEKSSNEATSKESPAPLHHRRRMHSRHRHLLVRKGESLLSARSEDSRPAAHFHLSSRRRHQGSMGYHGDMYIGNDNERNSYQGHFQTRDGVLTVTNTGLYYVYAQICYNNSHDQNGFIVFQGDTPFLQCLNTVPTNMPHKVHTCHTSGLIHLERNERIHLKDIHNDRNAVLREGNNRSYFGIFKV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASSGVAGGRQAEDTLQPPPELLPESKPPPPPQPLPVAALPPPAAPRPQSPAGAKEENYSFLPLVHNVIKCMDKDSPDLHQDLNALKTKFQELRKLIGTMPGIHVSPEQQQQQLHSLREQVRTKNELLQKYKSLCMFEIPKD
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular Localization:
Nucleus.
Sequence:
MPKYFCDYCDTYLTHDSPSVRKTHCNGRKHKENVRVYYQKWMEEQAQQLIDQTTAAFQAGKIPNNPFPNAAGQVGNEPGAKVLPPAILQAAAFQAGKIASNPFPTSQAGPGPQGGGTMIPPPPSLQGPGGPGSAPAPPRMPGPLLMTPPPGAAAPGMAPPGAPIWLVRHKTGMIAKPEALPQPARGPILLVPAGAVRPQMSVGAVMGPRLCKHSYHINKALFLIKIHTLQKATQSQLVVYKTVEKSK
The following text describes a protein:
Function:
Plays a role in the transcription of late viral genes. May function as an transcriptional initiation factor.
Subcellular Localization:
Host nucleus. Note=Co-localizes with IE1 in the nucleus of infected cells.
Sequence:
MSFDDGVVKAQTDPFALKRGGHNVQKWTSYALFKLFKEFRINKNYSKLIDFLTENFPNNVKNKTFNFSSTGHLFHSLHAYVPSVSDLVKERKQIRLQTEYLAKLFNNTINDFKLYTELYEFIERTEGVDCCCPCQLLHKSLLNTKNYVENLNCKLFDIKPPKFKKEPFDNILYKYSLNYKSLLLKKKEKHTSTGCTRKKKIKHRQILNDKVIYLQNSNKNKLFELSGLSLKSCRHDFVTVESQTRAGDEIASFIRYCRLCGMSGC
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSQEQSIEGLASNPFLALFTEHPSPSLSQPLIPGGVSTSSALAPPVQISSKQQDEEIRNISTADGESQEQILNDLLQRIFLITLKNDHDRLGCKAVGGLPKRCVYLRDSALDSETSLLSFANIDQALLERLTMQYPRNNVVITGRARSMSVLDEIEAGEGDIVKYLVQCFFRARTDATKLKVKQPEIFKHAENAKKLALSYVGTCMLSSEMFPNQNGHKQLFSLLMSSQDNRDIYQFMGDFVKEYTDADEVEMIFLPLIELLAEKQSEFDLVKPQTFQYLDFLLFISRQSHIAELLTKTSWLPPKPLPIFRNQPSISGRAFEKQTLLGGFLGLTSIATDPTKPSMMSELFATTLADDGFFLNLGTAMLRLCQPFLDPSSPKLLKIDPRYCAVAVTESSITQEDTPIHCIGLNEETRLIIPQDESTVSVEPTPAFGFVTECFFMTHYCLQLGFGKICEKYKSLMTRLSELQRVYQSTYDQGGESSLAGRLKDKFELGIIQQLSLKTHLLNPSMIELTLRFYIATTSWINQVALAGDNFLEMTEFVEVAMPLADQTPAALLFVPEFILDNMADFIIFLRHFSEETLETAGKGLHHLLTFFVIYMGSPERVKNPHLRAKLAEALECLVPVQREPREGQSPVTVYHRQLAFEQHAEAKKHLPCALLSLFVDIEFTGHSMQFEQKFGYRHHMYTVLEYLWSMQEYKQSILDLCSEYHRQLAFEQHAEAKKHLPCALLSLFVDIEFTGHSMQFEQKFGYRHHMYTVLEYLWSMQEYKQSILDLCSEMQQKNENSIILRFISLLINDAIYLLDESLDYMAQIKKKQLEEAEQESETLSEQERETRQRAFSQLSQMATSHNILGCKTVHTLSYLTTELKEPFVCSCVCSRIAAMLNYFLLQLVGPKMSKLKVKDFTEFHFKPQQLVSDIVDIYINLGTSEAFCKEVGRDERSYKPDLFIQAERVLKLIGRPASVLFQINEVARKVQEHLEEEEELPEPPEDYQDPIMNTLMRCPVRLPTSGKIMDKEIISRHLLSDQSDPFNRKHLTVSMLEPEEDLKAEIEEWIARNSTKSKGKSAGNDQKEMQS
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDWNQVTLEELASALKEVTWSAPRPVEEFFRSFSPPSQRALMGRLKNNLYYYRTNYLVILVLAFLVCFIRNPVALGSLVLVGLGTALCNDPFATSLNDNLLHALRKYAPRLVAKSRAKAGSDGVVGLHKRKRLYVLVLPRGLVVAALLLVGGLLVYWSHAVLTLCWAILLGVGLPLMHATFRLPNLKAKIASAREEFRAVWRGYQAELYNDHTHSM
The following text describes a protein:
Function:
This protein is a positive regulator of gene expression for the cysteine regulon. The inducer for CysB is N-acetylserine (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MKMHQLRYIVEIVNQNLNVTEAANALYTSQPGISKQVRLLEDELGLEIFERHGKHIKSITPAGKKIISIARELLVKAQGIRAVADEYTRPNHGVLRIATTNTQARYMLPSVIERFSKKYPDVSLHIHQGSPTQIHDALMSGEVDLAITTEAPYLFDDLVQIPCYWWNRAVIVSPEHPLAKVKELTIEELGKYPLVTYTFGFTGVSDLDYAFNSAGILPNIVFTATDADVIKTYVRLGLGVGIMASMAHTALDTDLVLIDASHLFRPSMTNIAFKHSTFLRNYMYDFMEYFSPHLTRSVVEKAERLRDNNSVKKLFEGIELETK
The following text describes a protein:
Function:
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
Sequence:
MPVFFLVYTSSIRKEKANSKGFKMAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYSTEPCWQYSDHHENKYCDLECSHTCNYKMRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEAGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHKTYSSILKHLN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
RMDIAYVCEWEKRPKSNHCPSIPLVCAWSCRNLLAFTTDLKNEEEEKDLTHMIHIIDSEHPWDVYSINSGHTEVISCLEWDQSGSRLLSADGDGQIKCWAMTEHLVNSWESTLGSAVEGDPIVALSWLHNGVKLALHVEKSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWMAVTVSGLVTVSLLKPNGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSAPVQFYKVCVSVVNEKCRIDTELLPSLFMRCTTDPARKDKYPAVTHLKFLTRENSEQVLLCASSQLGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPMILKWRILSATNDLDRVSAVALPKLPISISNTDLKVASDTKFCPGLGLALAFHDGSIHILHRLSLHTMGVFYGSSSSNPQRVGEEPALKRQRGGGPTTHFKALQFSCTSLALVGVDNHGKLHMLRVSPSMGQMLDINTLLRHLLFLLEYCMVTGYDWWDVLLHVQPNMVHNLVEKLHEEYMRQNQALQQVLSTRVVAMKASLCKLSSATAPRACDFHAKLLLIAISSTLKSLLRPHLLNTPDKSPGDRLAEICAKNTDTDIDKVMINLKTEEFVLDASTLQSLQQLIQWVGDFVLYLLANLPNQGSIVRPGFGFLRDGASLGLLREMMVVIRIWGLLKPGCLPIYTATSDNQDSMFLLFRLLTKLWLCSRDESHPQEPDEPLIDECCLLPSQLLVPAMDWLPVSDGIICKLQGKHPLRLQFGKPYSLPGLNSGTQVEIFTRTPGSQRMDNLRCLHMGVCPTEDSKACTRCGCVTMLRSPNKTTAVKQWEQRWIKNCLCGGLWRRIPTTIS