lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation.
Subcellular Localization:
Cell junction. Cell projection, axon. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MALTCPRRSFSESVQRSTGSSAVMWSTRLLFFFTLFTPVTLVLSRAPVPMAVVRRELSCEGYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENTRCYLPDAYKIMGFRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGVLRGVYQSEHLFESDHQAGSWCKDPLQSSNKIYYMPWTPYRTDTLTEYSSKEDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGRIVVSQLNPYTLRVEGSWDTSYDKRSASNAFMICGILYVVKSVYEDDDNEALGNKIDYMYNTEKSRETHLSIPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVIYSLDFGNNDNRLGFDPPSSVLLPDPLPPVRSSTTPPRPYTGTLRPSLTTTTTTTMVPPRRHNNVLPEALTRAPPSPQTPVTVDYCAPRLTAEISWPRTHQGQVAKQPCPPGTIGVATFNCLLGYWDPKGPDLSNCTSPWTNHITQRMRSGETAAIVARELAEQTKGELRPGDVPSTVKAMAQLVELLDVQLRNLTPGGKDTAARSLNKLQKRERSCRFFIQAMVETVNNLLQVRSQAAWRELSVAEQLRCATMLLDTVETGAFMLADNLLKTDTIQESTDNIQLEVARLSTDVNLADLSFPQSGLTGNSIHLSANTLKQQGRNGEIRMALVLYKNLGQYLSTENASVRLGSEAVYPNYSLIVNSPVITAAINKDSNKVYLSEPVVFTVKHIQQSEENFNPNCSFWSYSKRTMTGFWSTQDCRLLGTNRTHTSCSCTHLTNFAVLMAHVEVKKADQVHELLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFIAETLFLTGINRADQPIVCAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEYSRTKYFYLTGYGVPAVIVAVSAAVDYRSYGTERVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPDSGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCILQKKVRKEYGRCLRTHCCSGKSVESTISTSTKTSTARTPGRYSTNSQSRIRRMWNDTVRKQSESSFITADMNSSATLNRGTMANHLISNALLRPHGTNPYNTLLGESAVYNNPTANMFNTQASYRDSKGILNNARDSSVMDTLPLNGNHGNSYGVAAGDYLTYSSRGSEPPTTLEKKILKELTANYAPSYLNTQERQGKAHQGTLTNKLNNHLANGGVAGSSSIPKDDVMVLDNPGAFHRHDDGGGLSLELIREESQAPLLPPRPPPPENHAPLHTFTAHRRLPQENSESFFPLLPNDTHSSHTHTPRAHTHSPLRDSLYTSMPTLTDLPHGTDDLINGLHDDEDEEEEEDGEEEEGSELHLANGKGVIMESDDVYYKSMPNLGSRNHIQELESYYQMGRGGSDGFIAPPEKEDSSPEEQPPDPSQLVTSL
The following text describes a protein:
Function:
Involved in caffeate respiration, which consists in the reduction of the C-C double bond of caffeate. CarA catalyzes an energy-saving CoA loop for caffeate activation in the steady state of caffeate respiration. It catalyzes the formation of caffeyl-CoA from caffeate with hydrocaffeyl-CoA as the CoA donor via a ping-pong mechanism. In addition to caffeate, the enzyme can utilize 4-coumarate or ferulate as CoA acceptor. Neither acetyl-CoA nor butyryl-CoA served as the CoA donor.
Sequence:
MAKFISAKEAAKLIPDGSTVGVAGMGLAGWPEEVAVAIADNFKETGHPCNLTMKQGSAMGDWRERGMTRLGLEGLVTKWSAAHIGSAFAMNDLVRAEKMACHCLPQGVIVNLWREIAAKRPGLITKVGLGTFVDPRLEGGKMNKVTTEDLVELIEFNGEEYLFYKSFKLDVAMLRGTTADENGNITFENEGPINEGLAVAQAAKNSGGIVIVQVEYQALKNTLKPKDVKIPGALVDYVVVATDKNACWQTEGVYYEPAFAGNLRKPLSAIPILPLTERKVMARRAAMELSKGDLVNLGVGIPSDVASIVSEAGYIEEITMTTEIGGFGGIPASLPNFGSSYNAEANIDHGSMFDLYDGGGIDVAVLGLAQADEAGNINVSKFTIPGLGDRLTGPGGFINITQSTQKVVFAGSFNAKCEVEISDGKLIIKKEGRGKKLLKEVEQVTFSGKYAAENGQEILYVTERCVFKLINGKMTVIEIAPGIDLQKDILDQMDFTPAISADLKEMDSGLFSEKWDGLDTIMGK
The following text describes a protein:
Function:
Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function. May also act as a cell cycle regulator.
Subcellular Localization:
Cell projection, cilium. Cytoplasm. Note=Colocalizes with microtubules in interphase.
Sequence:
MAPKSKKAPSKKKMTKAERLRLMQEEEERRLKEEEEARLKFEKEEQERLEIQRIEREKWNLLEKKDLERRSQELEELALLEGCFPEAEKQKREIRALAQWKHYTECDGSPDPWVAQEMNTFISLWEEEKNQAFEQVMEKSKLVLSLIEKVKLILLETPTYELDHRTVLQHQGSILRLQELLSLKINVATELLLRQASNLADLDTGNMEKIIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSNVALRLLHTRYDHITPLFPIAVTEQNQNPVGAEQVNVEESTEKAMTEEKLFTEEKAANEDEQPKAEQERELNLVQEENKYEAIENTVLQRTSDSEGEDSQTTQLELEMKLLSEAVLAAQLCLVENVVELPEASQAYKVDLCHFSTLGGVYHLDVLELPPQCKPVKGWVLVEILQEGLQRFIYPPDTTEEPDPDVTFPPIEVTLEIHKSVIFFERPRVVRWDNEGKFWRSDGISSVYYNREDRLLTFSMDTLGPVTLIQDAHVNMPYQSWEMSPCGMNKVLLIVKTVFMELQIYIKENLCMLASVKLRGKGLEFHLKGKWMAPIPFILALKEAGLNIFPAVYSHFYVVINNKVPQVELKAYRQMALLSSAFSFGWSKWNMVCNSTRVVIRVREQLSEETEHHTWSLLMFSGDRAQMLKMQEENDKFSEALREGTEFHSTLYHMMKDFASPVAMERVRHSNCQFIDSVCYMLLSIRVLSYS
The following text describes a protein:
Function:
Probable acetylcholine-gated chloride channel subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. May function with lgc-46 to regulate synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons.
Subcellular Localization:
Presynaptic cell membrane; Multi-pass membrane protein. Cell projection, axon.
Sequence:
MRLIILVISILISNAGSLLRSLEDDSNECMFNCPKRARNVSVPHTEKTCMGDDAIIAQILDGYNKLDLPGGGHVVVSIEIWVQEVSKIIEITSEFELDIYVTERWTDPSLAYSHLNPCKSNMSVDGATILNKIWNPHACFVNSKLANIHESPFKNIFLQIYSNGSIWHNYRIKLTGPCSSTLRTFPIDQQRCMLFYESFTHNTDQVKMEWITTVPPITILKGNITLPDYVLVDFSSSSELRLYPPGIFNELIATFTFQRLYGFYILQVYVPAYISVFISWVSFTLGAEQIPSRTTVGVNSLLALTFQFGAVVNNLPKTSDVKAIDVWILSSMAFIFASLIELAVVGYLSRDGQHGSIKCRCSWLCMNCKDWTALKIDQMSSIVFPVSFLAFNIWYWFIFLGKLLVRTI
The following text describes a protein:
Function:
Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Subcellular Localization:
Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Domain:
The tandem UIM domains form a continuous 60 Angstrom-long alpha-helix and mediate binding to 'Lys-63'-linked ubiquitins. UIM1 and UIM2 bind to the proximal and distal ubiquitin moieties and recognize an 'Ile-44'-centered hydrophobic patch. Since UIMs don't interact with the 'Lys-63' isopeptide bond the UIM-linker region between the 2 UIM domains determines the selectivity for 'Lys-63'-linkage, and its length is very important for specificity; The Abraxas-interacting region (AIR) mediates the interaction with ABRAXAS1.
Sequence:
MPRRKKKVKEVSESRNLEKKDVETTSSVSVKRKRRLEDAFIVISDSDGEEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAREVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTEKTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYFWGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRASDWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFDLEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDSGTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKTSDADIKSSETGAFRVPSPGMEEAGCSREMQSSFTRRDLNESPVKSFVSISEATDCLVDFKKQVTVQPGSRTRTKAGRGRRRKF
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSFQDLTKVKAVFFYSHSGSRITAQYYDNSIPDEKRTDFENNIFKRASEDFDGQIMQHEEYITVYRNCNDVVGFVVGDLKANELLLDEVLETIFTALSLVYKKVSYDDLMKQIDLLYLLLDETIEQGYIFEGDPEIVAARVVLKDDKAFAGKAVRSSQGF
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MTSHADMTGSVMGTVADQEIANLSSKLSQVSDKFINQWTGVNLLQHLKHNEGQLRQFIKQAEDQIESLKGEMVALKQQASSSQLAVANQESQAKDIEKAIEQARTTTEQLLFQKEQWEKQLVEETKQCQEQKELIEAQERATRQRLEALNKAEHYFKDIMALEFRKIDGDHLQFVFTNVDSKNHDRSFYLTIKIDNSQYQVTDCCPAIDGIPEMVAGLNKSNNLMKFVVEARKKFKLTTT
The following text describes a protein:
Function:
Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Subcellular Localization:
Cytoplasm.
Sequence:
MHWPFCLSKCPYCDFNSHVRHAAIDEARFASAFAREIETTAQRAPGREVTSIFLGGGTPSLMQPATVGAVLDSIGKHWQVARDVEVTLEANPTSVEATRFAGYRAAGVNRVSLGVQALDDASLKALGRMHSAREALDAVAIARRSFERYSFDLIYARPDQTPAMWADELRLAIAEAAEHLSLYQLTIEEGTPFFGLHQAGKLKTPDEAVARALYDVTQETCDKLGLPAYEISNHARRGAECRHNLVYWRGDEYAGIGPGAHGRLDIDGIRHATATEKRPEAWLLRVETNGHGVVTDDLLNSEERADEFLLMGLRLAEGIDPERYTALSGRALDPKRIALLREEGAITVDATGRLRVTSSGFPVLDAVVADLAA
The following text describes a protein:
Function:
Binds the lower part of the 30S subunit head.
Sequence:
MSAPQRRLPVYKKILEENKKKWMIKEFLEYRLSKYGYIDSEILKTPLGTRIVIYAERPSRIIGRKGAIVKEISNILTTKLGVENPQIDVIDISKIEAPEMFPKVVAYRIANAMAKGVRFRRVMFVAIRQLMEAGAKGFEIVVSGKLSTERARFEKQTYGKLYKIGYDAKNRVRRAVVHVLLKPGIYGIEVRIAPATLQYSDEYKIKPPVRPEAVQQQS
The following text describes a protein:
Function:
E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MITNQQFNDNIEEFISIMLANLKLKGTDFEFSVNNNYVNKWNIDKMYSFVSVSVKQLRIDFTISFDDLYGVPLLNMRLYDNDTFLTSPMAQRTLAVGICRVDLHNHHLLQQPWLQVHPCETLQTIDSHLKNTPTCKYNSVIQYLCCWFGLYGLPSIFPQFSVRPNIYINNVQSCKIK
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MKPSLYSLLQRYLLLVNKCKHLGSRCWKHISAMEGSHHRLSVYSYQESLNSICNGKLKKDCHSLSKSVSTLSDGQGAEQKKHNVHKNHNRLFCQFTSDNNFLNSQSDKWSTMQVTVPDLYFVEGHSSHLSIDHPGDKSQPQNHYISAASSLNPREPDRNSFSKSDMLENISLLGISKMSMSKAQSFDRFDTQEVGIQKSYSDSFYNNKVPISSSPMIHNKNNATYFTLYSSTGISDAARDSGIVGSLSNIQNNLTEMMRSVRDQNISLYHLGSSNIKQNISLNSVPGTYQHRALEPMTSTNGFLNNSLICSQPHYNNPGLKSCDNICNIKHLQLYSSCKCHCCIAHKQVLKEDDTVAAFCHSLPIPSVQYSPGRLGSLGESVPSHTHPEFCSLPPPTSNFVFPKLVSSVSESGLDAKNLMRCGKLLFPQSIMSIGEMQLNRPDSNELLTKLSETSSINQQTTYLSKEMKDTWTMTSENQLSGEYRHPRHCKDAEVQTIVIMENKSVCTTPFLPNASHTHLFPEVGLALQCPRSPVREVRWDDEGMTWEVYGASMDPEVLGLAIQKHLDIQIEQHIQPSEESRDTKINPSTKEKRRSFRNLMHSLRQSSCCLCTNSTAE
The following text describes a protein:
Function:
Aphidicolan-16-beta-ol synthase; part of the gene cluster that mediates the biosynthesis of aphidicolin, a specific inhibitor of eukaryotic DNA synthesis and DNA polymerase alpha. The geranylgeranyl pyrophosphate synthase GGS is required for supplying a sufficient amount of geranylgeranyl diphosphate (GGDP), the general precursor of diterpenes. The diterpene synthase ACS then catalyzes the conversion of geranylgeranyl diphosphate to aphidicolan-16-beta-ol via the intermediate syn-copalyldiphosphate (syn-CDP). In addition to aphidicolan-16-beta-ol, the enzyme also produces low levels of amphidicol-15-ene and amphidicol-16-ene. The cytochrome P450 monooxygenase P450-2 then catalyzes the two-step hydroxylation from aphidicolan-16-beta-ol to 3-deoxyaphidicolin via a 17,3-deoxyaphidicolin intermediate. Finally, the cytochrome P450 monooxygenase P450-1 converts 3-deoxyaphidicolin to aphidicolin.
Miscellaneous:
MISCELLANEOUS: Part of a gene cluster that groups the genes involved in aphidicolin biosynthesis.
Domain:
The DXDD and DEXXE motifs are important for the catalytic activity.
Sequence:
MVPISTRSEVQDGLIAQARSLITRIVHNSDDVYGFGTLSCTVYDTAWVALVTKHVNGIKHWLFPESFHYILASQCDDGTWCEDKTAQFDGVLNTIAGLLVLKRYRRDPLQLKVDNRDLDSRIKLATSALHSLLEEWDVSTTNNVGFEIIVPTMLDLLVQEDPSLSFELKGREALTEIREAKMNRFQPELLYQGKLMTLTHSLEALLGRIDYDNVARYTVKGSMFASPSSTAAYLMSASTWDDEAETYLRYTITASTGKGSGGVPGVFPTTYFEYTWILSTLFRAGFQSSELDSPELTAMTDTLLKAFKAFSGAIGLDSGIEPDVDDSAKIVTTLNMLGKPAHARYLCDNFEVETHFRVYPRERDPSFSANCNALAAFLHQPDVEVYSSQILKAASYLCERMWNADEKIDDKWNKSHLYSSFLYTQVMTDLMAITEAGRLDGVFTRELLTRVCVTIFQSCLRAMLKQSHDGSWNQSLEETAYAILHLTEARRLCFFEQISEPLENSIYRGITFLTTIDKPPMEYLWSDKVSYGSAYLAETYVLAARRAAESTSVTNLVGSSIWKDNASTKMHKLVGLFHRTPLLKALPKWELQASMIEASIYQGLLQDARLEVLQRPKVDGGEYLSIIPFTWTSCSNSARTNASASHLWELMALSFFTYQVDEFMEAVAGPAFKGRMTHLHAIIDEAVHCSQNRERTPGECENTNHVTSELLQAVRFILDNPTVRKASPYDRNTLLQELRIFLHAHVTQVEDNASFGRERLTGDKALTSYRSQLYRWVHTISSDHIAGPFCFYYATCLLGATLTAHPPNDCFPKSSQKYLAAATCRHLSCMCRMYNDIGSWNRDHREGNLNCLHFPEFSETTSDDAERKASLLTLAQYERKQWCNALQQLEKEMVHGASEPAAARLAKRRACLIDMFCKVTDLYGQIYVLRDVSSVIKDVVRNGE
The following text describes a protein:
Function:
May be involved in plant development processes.
Sequence:
MESRMDQYEIMEQIGRGAFGAAILVNHKIEKKKYVLKKIRLARQTERCRKSAHQEMALIARLQHPYIVEFKEAWVEKGCYVCIITGYCEGGDVDELMKKLNGTYFPEEKLLKWFAQLVLAVDYLHSNYVLHRDLKCSNIFLTKDHDIRLGDFGLAKTLKEDDLTSSVVGTPNYMCPELLTDIPYGFKSDIWSLGCCMYEMAAHRPAFKAFDMAGLISKINRSAMGPLPTCYSSSMKSLIKIMLRKNPEHRPTASEILKNPYLQPYVDQCRALYDASNTMRTPPKSLSTSRSSQRSMSESQSSSMSSSDIDSTLSSDRSTSGGAASTDTKVIDTRSVHDVDRDNSDEKCATPEDLRGNKDLKRQDSSKSIDQHHRGESKQPKIIEKIMTTLREESRLRESNTPARTRGVKPSSAASNKNEAEQPSDTSRFNNNNASCRSRSGDDSSHGLVSTNDGCVNSVQASPPSKQLLPIVEHRSNIRTSRSSTPEPAKQVIENGSAVSAKSKMKTPSSATRRASPQRRVGVGTTGLPATVQKGAQTKVMVEGEKSPCQRVHSPDNTPGDLPLTVRPSKIPSEGLNIMPNNSHAKSAPRELFTVATKEDISPCSSSTVGCVEKIDQSEISEPNPPACLISSHTSSVPDAAAVPEDNGLTAIPRSEINTEKSQRSAVSNDSSLSSALGPSIPSFEQEFVCKDDVQSSKHGQNMATFQSGEDKFTVQELLSSMLPYDSSVSTAEDTMLDKGPNSVQSMKKQTSMKKETGPHLNPLVDDAMRQINFNVSNEQPISENVQGETQNMDVSKLLNVVREDLEVRSSSCSLNSLPSTPLPSVASEQHALGSNAACKIPAGSDTARLSSAIVDVRSYISEANIVVKEETSPAKEMLDVTSFRQRAEALEGLLELSADLLEDNRLEELAIVLKPFGKMKVSPRETAIWLARSFKGMMNDEASRTSM
The following text describes a protein:
Function:
Part of the xanthophyll (or violaxanthin) cycle for controlling the concentration of zeaxanthin in chloroplasts. Catalyzes the two-step mono de-epoxidation reaction. Stereospecific for all-trans xanthophylls. Zeaxanthin induces the dissipation of excitation energy in the chlorophyll of the light-harvesting protein complex of photosystem II.
Miscellaneous:
MISCELLANEOUS: The amount of VDE in vivo is estimated to be 1 molecule per 20-100 electron transport chains.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Domain:
The cysteine rich N-terminal region is required for activity.
Sequence:
MAVATHCFTSPCHDRIRFFSSDDGIGRLGITRKRINGTFLLKILPPIQSADLRTTGGRSSRPLSAFRSGFSKGIFDIVPLPSKNELKELTAPLLLKLVGVLACAFLIVPSADAVDALKTCACLLKGCRIELAKCIANPACAANVACLQTCNNRPDETECQIKCGDLFENSVVDEFNECAVSRKKCVPRKSDLGEFPAPDPSVLVQNFNISDFNGKWYITSGLNPTFDAFDCQLHEFHTEGDNKLVGNISWRIKTLDSGFFTRSAVQKFVQDPNQPGVLYNHDNEYLHYQDDWYILSSKIENKPEDYIFVYYRGRNDAWDGYGGAVVYTRSSVLPNSIIPELEKAAKSIGRDFSTFIRTDNTCGPEPALVERIEKTVEEGERIIVKEVEEIEEEVEKEVEKVGRTEMTLFQRLAEGFNELKQDEENFVRELSKEEMEFLDEIKMEASEVEKLFGKALPIRKVR
The following text describes a protein:
Function:
Encodes a member of the mid-SUN subfamily of SUN-domain proteins that is localized to both the nuclear envelope and the ER. It is involved in early seed development and nuclear morphology. [TAIR].
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MQRSRRALLQRRALEKTTNGRNRLYMLFLSLIFVLWGLFFLFSLWIRQSNSRKDGCTYLQDSISTWNESKYENYKHSEIISESHQNKNCSVVLLKDQFIDSAKSRAFDDANFVREENEKDDNFDEKVNLLSFGELPDVKNDNGLGGNFQTDTLNFDRLSHVLPLGLEVFKSRAFISETKTRTGQVESTFHRLEPSGAEYNYAAASKGSKVLEFNKEAKGASNILERDTDKYLRNPCSAEEKFVTLELSEETLVRTIKIANFEHHSSNLKEFELLGSSIYPTDVWIKLGNFTAANAKHAQRFALKEPKWVRYLKLRLLSHHGSEFYCTLSVFEAYGLDAVEEMLEDLVSVHDNTIISTGLPADNEPKTKYKNEHHNYDGEVSSLRNDADIVEDFVKQDVPDRFQELRHHHQAGRMPGDTVLKILMQKVRSSDLNLSILERYLEELHSKYGNIFKQFNDDIRENDILVEKSREDIRNLLRVQESIGKDVNDLISWRSFISLQLENLLRDNAILRSEMNKVREKQNAEENQGGMMAFVCIVFLLFGVIRVFIDVMVSVYRRTRSVEKKSKSGNFGMISSWILLLLSCSIFILILL
The following text describes a protein:
Function:
May act as a calcium-activated chloride channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MREGGAGEGQGAAVDEATGFEVGIVVPKLYRGAAAGCGEVENCVARLVRELEDVGLIVERVRGVPAEFIKLSAPMGTLGRVAAEMNMKKLTYIGMELQFEWDQVGAFVRQPDGSLFSWRERFACFRHLIYSIVNKTDSDITLSFDDKEFHWTQNESLLTRLEDEGIVKLVFPLHDEIKRKQLLRSWALKWFDFTWQPIDEIYSYFGTKIAIYFSFLGMYTRWLFFPAVFGLATQLIDFGSLQWLVLPAFFFFVISWAVFFLQFWKRKNSAVLARWGINYSFSEYKTMGNELDPLSFSMADDNVQQRKFGAPKEKSIVQRNEWFGVLLRIRNNAIIVLAIICLQLPFELAYAHLYAITKTEALRYVLTAVYLAAIQYYTRIGGKVSVTLIKYENNQGEQSSADSLVYKVFGLYFMQSYIGLFYHASLHRNIMALRQVLIKRLIVSQVLENLIENSIPYLNYSYKKYRAVHKKKHEKESPAGKSVRLSTRVEKEYLKPSYTASIGEELEDGLFDDFLELTLQFGMIMMFACAFPSIFCFAALNNVTEIRADALKLLVMLKRPAPRDAATIGAWLNIFQFLVVMAICTNCLLLVCLYDEEGKWKIEPGLAAILIMEHALFLIKFGFSHFVPEEPAWVKANRGRYVAQAQNVCSKQLLRSIAKLDAKLE
The following text describes a protein:
Function:
C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the liberation of two electrons, which may be transferred from the SoxAX complex to another cytochrome c that then channels them into the respiratory electron transport chain. Some electrons may be used for reductive CO(2) fixation.
Subcellular Localization:
Periplasm.
Sequence:
MKKTVTAVALLCALSSTAIAPTFAADDDEAARLKAIEEYRKQIADGNPSDLLAMEGEELWRTPYGPKNQSLEQCDLGLGPGVVKGAAAKLPRYFPDTGKVEDLESRLMTCMERLQGVERQKVIDSPWRKGEKLRMDKIVAYIVTESNGEKIDVDMSHPKMKEMYELGKRMFFYRTGPFDFSCATCHGKDGQRIRLQELPNLTKHEGAAAGWGSWPAYRVSNSQFWTMQMRLNDCFRQQRTAEPIYGSDATIALSVYMAANGNGGVMLTPGIKR
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATFSYTIPLPIRCSTTGNKQDPKKQNLNKIKITGTPTRSVKVDTLSQTAGVAKTSVASVENGHISKEQIRQNIPTKKQFVDYHRQGLIVEGGVGYRQTVVIRSYEVGADKTATLESILNLLQETALNHVWMSGLLSNGFGATHGMMKNNLIWVVSRMQVLVDQYPICDIAVPFFFSLVKSAHSPESHIVWKQMNVSCRGEIVEIDTWVGASGKNGMRRDWLIRSQATGHVFARATSTWVMMNEKTRRLSKMPEEVRTEISPWFIEKQAIHEDVPEKISKLDSNAKYVNSNLKTIPDQFLESHQLSGIILEYRRECGSSNIVQSLCEPDEDGILNSGLKQNNDMSPLNRFSLASEIMEGNGLLGSLDKVPLRYTHLLQTQGDTQNEEIVRGKTTWKKKQSNIELSNMPFSI
The following text describes a protein:
Function:
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYTIGIAGCGNMGGAIYFSLKERYPTQVLGYDPYIISNQKIELISSWDEFVSKSDLILVCVKPGKVIELLRQIKVPKKIISVAAGIHIDTILKNLPTGSNVVRVMPNLPLLVSEGAIGFFGDEELYETVSEIFQPLGHSVKLGSETLMDAVTGLSGSGPAYVFKFIQALAEGGVLSGLGYQEALDLSIQTVIGSAQLLRKEREKDPTTHPEVWKNKVTSPGGTTIAGLVELEKNGFSNAVLEAVKAAANRSKELGV
The following text describes a protein:
Function:
Acts as a GTPase-activating protein for Rab family protein (s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function. Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail. Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3. May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids.
Sequence:
MTTLSPENSLSARRSATFILEKRNPPIDKAEWDSFFDENGHLAKSRDFICINILERGLHPFVRTEAWKFLTGYYSWQSSRDERLMVDSNRRRNYNSLCQMYEKIQPLLENLHGNFTETRNNIAYDIQRLYDKDPLGNVLIDKKKLEKTLLLSYVCNTKAEYQRGFHEMVMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNSLITLLDPEFAEHLKGKGSGAVQSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLECMSGDAILMACNNLIDLDADELISAACVVYSELMQKEVPQPLKEFLL
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MANRTDASAIKNFGSNPQYLISNIIRSKIYDSPYWKEKCFALTSESIIDQAINLKYVGGTYGGNRKPTRFLCLILKLLQIQPDKDIIYEYIKNEDFVYLRALGIFYLRLIGKSLEVYNHLEPILFDYRKIRMRLQNGTFEKIYMDVFVDNCLILNNFLDVDFPTLTKRQVLEENNLLQRKNLEYYKALLNISSDNELFKNNEDTTHNKNKEINKNKNEYKQRDMLERHKKINKYSSEDDHNYYHKKEGNYDKNKKHNKIYNHKYNNKYDDEERRHHSDYSSDMDRKSRKKEKKRTHSKYDHKKKKEKRNYSSDSKHSFTSSEYSVQNKKEEHDKKKKKLFFLKKQKKKNYHSSSQSNHSYDENKKDELSIDKWNEIRKELGMKPLK
The following text describes a protein:
Function:
Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
Subcellular Localization:
Cell projection, axon. Presynapse. Cytoplasmic vesicle, clathrin-coated vesicle. Note=In primary cultures, mainly present at axonal and presynaptic terminal levels of mature neurons. In immature neurons, localizes to the cell body and growing processes, including axons.
Sequence:
MAHCGAGGAAPAGLPRSPGLGRKGLPRKGSGERRRLKAVVSEQLSRDVLRLLREEMHTDMVLSVSGSLFKVHRAVLLARAPGFHSHITGHTSRGLTDELIPVDSVEASEFKAFLQIVYSSNKSVKNYEEEILQKMQVGNVMPEKGLDVSFLQCRTSSDCFLGKHEIPADVTSGGDSFISKDDCDLEPVSELGADLLKLYLSQDYHDIDICVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQECITLQGITHVEMSVMMHFIYGGTLDFPEKANVGQILNVADMYGLEGLREVAIYVLRRDYCNFFQKPVPRTWASILECLVIAHSVGVESLFADCMNCIISHFARFWSERSFANVPPEIQKTCLSMQIQSLNHGNAALLLMESDKLITGLPRVKWTEAALSMASQLQGECVTFIVQNFSQVMESASFTLLLQSQAMSSTAHLLDKIFKAIEDSITAENSCSLLMALDTLLKSDSAEEMGFTCRIQAVRDKLWTFLVQSFYAVRHTESWKLMHIDDQQKIQAAALDKGDDRRLGRKPVLSSSQQRRQGSDVIKIKPWTGNNKKLCRASPSTNEKMRSDGLGASGHASGTHRNSVNKVSKHGEGTKVSKVTTEVKTGATHVPGKPKTTIKPQTENNAHTKLESISSTVVGRPARMAATGRKDLAHGKGIQNQEGETTGARPKVLTANLNTQARAKPLQTVKGKDNGCSATVGPSSRSANSSMERLASTGSVDETKENGSVEDKSCDKKPYVSASPGQMVYNGVTSTVAVKSRPVSRVTSGTSSKKSFIHEQGPSVTSSVIKKGRGSSKGLNDSAPQTAAKRGGSSNGYAAAQPRTKSAPPTLAQTQGSQGESPHSVKSSISSRQSDESVTRLRHGTDKQMPKRKVVKQGHATLQKVNAKPTPKNPSQSTKGGTMTSKDSKQKVLPGQVTLQSQASQRPSNPEAATTQRSVLHGVNDNRSQVFKQRPPESLVNLASDTNGPEASPSPCRPQPQSPLGNQEKTRQEREHQDGSTLGDSVKHELRSELTSIEQSHTPAYKVSSQCSANPNCGCIASLKPVTSNPSENWINSNTANTDQVCVSDRERQTGRKGTDREPSVNCVARKAALPSVPAGMSGTLKSAQDDRKLPFHREELSAQGHLPHDCATEDSKCATPTSAVSSRCLLGQPSEKGYKNMEASGTSESHEAPEAPFMGPWDLNTSATHQRESPESDTGSATTSSDDIKPRSEDYDAGGSQDDEGSHDRGVSKCSTALCHDFLGRSSSDTSTPEELKVHEGDLRTEVRVRKPGGGDLPLHSASDDETPRKKPDPWSRSTIVHPREKGSAPRGSVPSAQEVDQVSSSADETEDERSEAENVREHSSPSNSGTQHVQGIINLAFEDGTEHESREFSATKKFRRSVLLSVDECEEVGSDEGEGHTPLQPSLDSLSPSDVFDGVSYEHHGRTGYSRFFKENEATTAEHKYSRGNDGHKNEGFLLSPRSRDFPRQGKQCVSTGEKTRLDVPPKASQQPFPESKDMTSKREVAHGLQQHGTLTDGDTRSQERPCHLELHQREPSSTIPKISSARSLDSCPSQVLPQDGQVTATHPTPPKRANNAVFSGDIDDCDTMAQTTMYDHRPSKTLSPIHEMSLTAACEQKEESGTHVADRASEDEQPFAKQDWTLLKQLLSEQDANLNVTSSLPEDLSLAQYLINQTLLLARDSSKPQGSAHADTWNRWSELSSPLDDLTASATTVSVSSTDCSPQGEWTILELETQH