lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MASLLGAYPWPEGLECPALDAELSDGQSPPAVPRPPGDKGSESRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRPRRKKQAKRLCKRVDPGFLLSSLSRDQNALPEKRSGSRGALGEKEDRGEYSPGTALPSLRGCYHEGPAGGGGGGTPSSVDTYPYGLPTPPEMSPLDVLEPEQTFFSSPCQEEHGHPRRIPHLPGHPYSPEYAPSPLHCSHPLGSLALGQSPGVSMMSPVPGCPPSPAYYSPATYHPLHSNLQAHLGQLSPPPEHPGFDALDQLSQVELLGDMDRNEFDQYLNTPGHPDSATGAMALSGHVPVSQVTPTGPTETSLISVLADATATYYNSYSVS
The following text describes a protein:
Function:
Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Has a high substrate specificity to fibrin.
Miscellaneous:
MISCELLANEOUS: Secretion of subtilisin is associated with onset of sporulation, and many mutations which block sporulation at early stages affect expression levels of subtilisin. However, subtilisin is not necessary for normal sporulation.
Subcellular Localization:
Secreted.
Sequence:
MRGKKVWISLLFALALIFTMAFGSTSSAQAAGKSNGEKKYIVGFKQTMSTMSAAKKKDVISEKGGKVQKQFKYVDAASATLNEKAVKELKKDPSVAYVEEDHVAHAYAQSVPYGVSQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLKVAGGASMVPSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASLYAVKVLGADGSGQYSWIINGIEWAIANNMDVINMSLGGPSGSAALKAAVDKAVASGVVVVAAAGNEGTSGSSSTVGYPGKYPSVIAVGAVDSSNQRASFSSVGPELDVMAPGVSIQSTLPGNKYGAYNGTSMASPHVAGAAALILSKHPNWTNTQVRSSLENTTTKLGDSFYYGKGLINVQAAAQ
The following text describes a protein:
Function:
5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNLVVFGTNAHPELTKAICSRLSIPVGHVELGQFSNGETSVKVKQSVRGCDVYIISPAAGDVNDHFMELLILISACKTASAKKVTAVVPIFPYSRQPDQRYSSAGAPVQAMNQLSITKSAPAPVTAYREWIAQSGTLVADLLMCSGADHIITMDLHDAQFQGFFDVPVDNLYGRPLLERYISLHIPNYQDAVVVSPDAGGAKRATAIADSMMMDFALIHKNRPHAFGTSLMLVGDVRNKVAILIDDLVDTGTTLVRAAELLKEHGASTIYALVTHAVLSDNALERIENSSIDKLVVTNSAPQGETEKDYVDVIDVAPVFAESIRRIHNGESISILYKRNNLLY
The following text describes a protein:
Function:
May play a regulatory role under conditions of derepressed gsp gene expression.
Miscellaneous:
MISCELLANEOUS: Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSTRREVILSWLCEKRQTWRLCYLLGEAGSGKTWLAQQLQKDKHRRVITLSLVVSWQGKAAWIVTDDNAAEQGCRDSAWTRDEMAGQLLHALHRTDSRCPLIIIENAHLNHRRILDDLQRAISLIPDGQFLLIGRPDRKVERDFKKQGIELVSIGRLTEHELKASILEGQNIDQPDLLLTARVLKRIALLCRGDRRKLALAGETIRLLQQAEQTSVFTAKQWRMIYRILGDNRPRKMQLAVVMSGTIIALTCGWLLLSSFTATLPVPAWLIPVTPVVKQDMTKDIAHVVMRDSEALSVLYGVWGYEVPADSAWCDQAVRAGLACKSGNASLQTLVDQNLPWIASLKVGDKKLPVVVVRVGEASVDVLVGQQTWTLTHKWFESVWTGDYLLLWKMSPEGESTITRDSSEEEILWLETMLNRALHISTEPSAEWRPLLVEKIKQFQKSHHLKTDGVVGFSTLVHLWQVAGESAYLYRDEANISPETTVKGK
The following text describes a protein:
Function:
Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O-methylglucosyl lipopolysaccharides (MGLP).
Sequence:
MCAFVPHVPRHSRGDNPPSASTASPAVLTLTGERTIPDLDIENYWFRRHQVVYQRLAPRCTARDVLEAGCGEGYGADLIACVARQVIAVDYDETAVAHVRSRYPRVEVMQANLAELPLPDASVDVVVNFQVIEHLWDQARFVRECARVLRGSGLLMVSTPNRITFSPGRDTPINPFHTRELNADELTSLLIDAGFVDVAMCGLFHGPRLRDMDARHGGSIIDAQIMRAVAGAPWPPELAADVAAVTTADFEMVAAGHDRDIDDSLDLIAIAVRP
The following text describes a protein:
Function:
Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
Sequence:
MTLDTMKEHGMLCCLLPTIVYLLLPDLPITGASTDCVKIENCQENHNGSSLKFKYPNVQLDISVLRGKYMDPSMLCKAEGFTSITWLKDDRIEFPFGFMPGSSKCYTSLKDCNQTVEITNTQKEAIGNYTCLVSNGEETIQRTFHVYVEDEKFTDDPSTIDHANCSDMAVKPGEDVYLFCEFCAGDKSHVTEVRWNKLDEDENLVPVNQLTDGEDEDGSRYWESPNTYSRDCFETYNLPAAVGRQLIIRDVTSGMFGSYVITGNYTLNGAYKGDSIKIIVSQAPDTMIEITVGVVVSLTVIFLVVTVVTVTCHKYHLTLQLYWKNRFGKIEEHDGMEHDAFISFSDSPEDGRFAIAVAQRLHQQGYDAWMRDMHAIPGEALIAEEIVSMKRSRRCILIISPEYSTSSHSEVLTDLAADQTLRKRSRIIPILYRGVTREHFKRHRRLAEIVRVCPCITWQEMEDAGSSENQLGNSISGSSPEGVHGNGSSGSGLGEMPNNDVSGSGLGQMLSNNVSGSSTEELPSNVSGCGTGEMPIDSNTSINSTNDDEGTLACHSNNGMRMTRRDGDSDQLIEDQEEGERKKREMKTKKQREKYEKRLLLKMPPKRLVASHAGNVASMVV
The following text describes a protein:
Function:
Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus and could also play a role in the integration of nascent murein strands into the sacculus.
Miscellaneous:
MISCELLANEOUS: In E.coli there are three murein endopeptidases: two are penicillin sensitive (DacB and PbpG), the other (MepA) not.
Subcellular Localization:
Periplasm.
Sequence:
MNKTAIALLALLASSASLAATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYFGHPDLVMFIQRLSSQVSNLGMGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWTSAQLLRPQALDLVSRDGKHVVSTLWKPEIFSLIKLAAQDKDVTRIFVNPAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPSGDGCGAELQSWFEPPKPGTTKPEKKTPPPLPPSCQALLDEHVI
The following text describes a protein:
Function:
Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLPPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEEEENDMIEGIPEGKDKHRINKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPTVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHPSKAYIASAGADALAKVFV
The following text describes a protein:
Function:
Minus-end microtubule-dependent motor protein involved in the regulation of cell division.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNGGGASGGDGYDSDGYSFAPPTPTTLSMSIPPELAGAIPLIDRFQVEGFLKAMQKQIHSAGKRGFFSKKSVGPHVREKFTLEDMLCFQKDPIPTSLLKISSDLVSRSIKLFHVILKYMGIDSPAIISLDERIELVAKLYKHTLKRSELRDELFAQISKQTRNNPDRAWLIRAWELMYLCASSMPPSKDIGAYLSEYVHYIAHGATTDSDVRVLALNTLNALKRSVKAGPRVTIPAREEIEALLSSRKLTTIVFFLDETFEEITYDMATTVADAVEELAGIIKLSVYSSFSLFECRKVVNGSKSSDVGNEEYIGLDDNKYIGDLLSEFKAAKDRNKGEILHCKLVFKKRLFRESDEAITDPMFVQLSYVQLQHDYILGNYPVGRDDAAQLSALQILVEIGFVDNPESCVEWISLLERFLPRQVAITRAKRDWELDIVSRYQLMEHLSKDDARQQFLRILRTLPYGNSVFFSVRKIDDPIGLLPGRIILGINKRGVHFFRPVPKEYLHSAELRDIMQFGSSNTAVFFKMRVAGVLHIFQFETKQGEEICVALQTHINDVMLRRYSKARSATSAVSQNDVSQTYKPPNIEIYEKRVQELSKAVEESERKADLLNEELQKKTKQERDMQKELEGLRDTLQSERQSIKEVTNDLDKLKSLCDEKDSSLQASLMEKTRLETRLKSGQGQESSNRTGVSGNHFERDTLPTVGTVNNSIEMLAKLEEELKSCKKELDASKELSKKLTMENNLLDQKVQRLERAKSEEKSNMERVYEDECCKLKSRIAELEQKLESRTRSLNVTESTLALRNAEVDTLQNSLKELDELREFKADVDRKNQQTAEILKRQGAQLIELENLYKQEQVLRKRYYNTIEDMKGKIRVFCRLRPLNDKELIEKDKNIVCSPDEFTVAHPWKDDKSKQHIYDRVFDANTTQEEVFEDTKYLVQSAVDGYNVCIFAYGQTGSGKTFTIYGSENNPGLTPRATSELFRVIKRDGHKYSFSLKAYMVELYQDNLVDLLLAKNATHQKLEIKKDSKGVVTVENVTVVNISSFEELRAIILRGSERRHTAGTNMNVESSRSHLILSIIIESTNLQTQSYARGKLSFVDLAGSERVKKSGSAGKQLKEAQSINKSLSALADVIGALSSDGQHIPYRNHKLTMLMSDSLGGNAKTLMFVNVSPAESNLEETYNSLMYASRVRCIVNDTSKHVAPKEIMRLKKLIAYWKEQAGKRSEDDDLEEIQEERTPKEKADNRLTS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKRVDRAGKCYEGSLDTFWTGGGGRSRRRMDLWIKNWPDKEKNWSLHAAGYRLVPFGSEISNRNITRSAGFHSNQDVHHSLSQMQSQTTSLLDNKGGRSSNQNYFKDMSSSVLNETIERNTNKQCQHGFRESKRSQNLKSLDSFINKMTPSSKKLNIVSKISSTFKPFICPKCKRRFCSIQNLHTHQRIHTGRRFVCSKCGKCFSHRKILTAHKWLHTGRKPFTCAECNNGFLWNRDLQEHEKDHKNGKMNISHPETQSQGNSYHYTEYRTSCRNKSMCKTPFKTHTKNKTCICSECGKSFRHRGQLNVHLRIHTGEKPFVCTECGKGFRKKYKLKNHLGTHREGRPHVCTECGKTYKHRSGLSAHLHSHTRVKPFACSECRKTFHCKTQLNIHLRYHTGKTFPCTECDKTFTQKKNLKRHQMIHTGEKPFECTECGKGFREKRKLQLHCLIHSGLKPFECLECGRQFRWKQGFEYHQLSHTGERPYECSECGRGFKSSGDLGLHVRIHTGEKPFICNERGKNFKDPGVLDRHLHIHTGEKPFICNERGKSFKDPGVLDRHLHIHKLEKPFVCVECGKRYRELCLLRSHLQTHIRIEKFVCPECGKGYISNRCFETHLLTHTR
The following text describes a protein:
Function:
May be involved in the control of meiotic sister-chromatid recombination.
Miscellaneous:
MISCELLANEOUS: Present with 7250 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSHNALRAFDCSKVIISRRCLTSSTSIYQQSSVHLQETDDGHSGNREKHVSPFERVQNLAADLKNELKAPDSDINEVFNDFKDKIESLKQKLRNPSPMERSHLLANFSSDLLQELSYRSKNMTLDPYQVLNTLCQYKLARSQHFTIVLKYLLYNQSPQDVIALWVKYLETISENPVILLQNSSSRAHMQNIAITTIAYLSLPENTVDINILYKILQIDRKMGQVLPFNMIRRMLSTEFSSLERRDVIIKNLNTLYYQYTVQDSDHFLSQIENAPRWIDLRDLYGQYNKLEGEKNVEIISKFMDKFIDLDKPDQVVTIYNQYSKVFPNSTSLKDCLLRAVSHLRAKSSKEKLDRILAVWNSVIKPGDNIKNTSYATLVNALTDSGNFNHLKEFWEEELPKKFKKDPIVKEAFLLALCQTSPLKYDQVKGELAETVKTKKLFNKVLLLMLDDEKVSEEQFNTFYYNHYPSDGVLPPTLDTLSIKMYANYKFQAEDTRPQFDLLQSVSINPTDYEKVEKITKAFISVCPTVEPIRQLYKQLGTHLNARNYADFISAEFNKPDGTVAEAKNLFSDFLSYQKTRKRNVDNTPLNALLLGFCDKLYKSKHSEYVPYIEKYYNLAKDSSIRVSNLAVSKILFNLATFARNTQQLSDKEVAFINQFMRDLGTNEGFRPNPKDIQILKECDGITVPEKLT
The following text describes a protein:
Function:
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
Subcellular Localization:
Nucleus.
Sequence:
MCIQPDSLEDAYKIPRPVHREEFTQLSPSFFQTATFQLEKTNEKNNIEEPKKNKAFLNSKIIYKDLFEIRKLSNNFVNTSHPTCTETMNEQNEFSDEENFKFFGLGGCNEVGRSCHIIEYKNKVIMLDSGMHPALSGHASFPYFDEYDISKVDILLISHFHVDHSASLPYVMQQSNFRGKVFMTHATKAIYRWLMQDFVRVTSIGNSRSEDGGGGEGSNLYTDDDIMKSFDRIETIDYHSTMEIDGIRFTAYHAGHVLGACMYFIEIGGLKVLFTGDYSREENRHLHAAEVPPLKPDILISESTFGTGTLEPRIELERKLTTHIHATIAKGGRVLLPVFALGNAQELLLILDEYWSQNEDLQNVNVFYASNLAKKCMAVYETYTGIMNDKIRLSSASSEKSNPFDFKYIKSIKDLSKFQDMGPSVVVATPGMLQAGVSRQLLEKWAPDGKNLVILTGYSVEGTMAKELLKEPTMIQSATNPDMTIPRRIGIEEISFAAHVDFQQNSEFIEKVSPSKVILVHGDSVPMGRLKSALLSKYASRKGTDQEVKVYNPKNCEELIIGFKGLKIAKVLGSLAEEQLQVLKKIIQDEVSAENSKITELTEEKEEADEIKEDNGETDTTQKPNESSINVLKTGQVVSGVLVSKDFNLNLLQLQDLHEFTQLSTSIVKSKMHLKINADISLMVWHLEQMFGYINVINDDDEEWECVIMDVVDVFIDRSKGPGLFITVEWINDNLMADSLADSVIAILYSIDSSPASVKLSSQNHNHGDNHIVKKEDSMEIDRPVEAHAKTDIKSRIERIALLLKAQFGDSLKELPEEKAIIQIGKTVANVDYKRLEVECSSKVLKDRVENVIKRGCQLTAPLSQNPKIA
The following text describes a protein:
Function:
Phytoene desaturase involved in the carotenoid biosynthesis pathway. Converts phytoene into 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene, by introducing up to five double bonds into phytoene. Is also able to desaturate 1-hydroxyneurosporene into 1-hydroxylycopene and 1-hydroxylycopene into 1-hydroxy-3,4-didehydrolycopene. Gamma-carotene and 1,19-dihydroxylycopene are not accepted as substrates. Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene. Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene. Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta-carotene by an additional al-2 cyclization reaction. Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAETQRPRSAIIVGAGAGGIAVAARLAKAGVDVTVLEKNDFTGGRCSLIHTKAGYRFDQGPSLLLLPGLFRETFEDLGTTLEQEDVELLQCFPNYNIWFSDGKRFSPTTDNATMKVEIEKWEGPDGFRRYLSWLAEGHQHYETSLRHVLHRNFKSILELADPRLVVTLLMALHPFESIWHRAGRYFKTDRMQRVFTFATMYMGMSPFDAPATYSLLQYSELAEGIWYPRGGFHKVLDALVKIGERMGVKYRLNTGVSQVLTDGGKNGKKPKATGVQLENGEVLNADLVVVNADLVYTYNNLLPKEIGGIKKYANKLNNRKASCSSISFYWSLSGMAKELETHNIFLAEEYKESFDAIFERQALPDDPSFYIHVPSRVDPSAAPPDRDAVIALVPVGHLLQNGQPELDWPTLVSKARAGVLATIQARTGLSLSPLITEEIVNTPYTWETKFNLSKGAILGLAHDFFNVLAFRPRTKAQGMDNAYFVGASTHPGTGVPIVLAGAKITAEQILEETFPKNTKVPWTTNEERNSERMRKEMDEKITEEGIIMRSNSSKPGRRGSDAFEGAMEVVNLLSQRAFPLLVALMGVLYFLLFVR
The following text describes a protein:
Function:
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MPTDNDLKAAILELLRDLDVLLVAHFYQKDEIVELAHYTGDSLELAKIASQSDKNLIVFCGVHFMGESVKALAFDKQVIMPKLSCCSMARMIDSHYYDRSVHLLKECGVKEFYPITYINSNAEVKAKVAKDDGVVCTSRNASKIFNHALKQNKKIFFLPDKCLGENLALENGLKSAILGANSQEEIKNADVVCYNGFCSVHQLFKLEDIEFYRQKYPDILIAVHPECEPSVVSNADFSGSTSQIIEFVEKLSPNQKVAIGTESHLVNRLKAKRHHQNTFILSSTLALCPTMNETTLKDLFEVLKAYKNHRAYNTIELKDEVARLAKLALTKMMELS
The following text describes a protein:
Function:
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.
Sequence:
MAKNKDDEESYCGGGGYWDMVEDLEEEICFDAQEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPPKIKEFTTLCINIEDESQKDISSYFQQCHGFIENGRKLGGILVHCSAGVSRSASVVISYLMSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEATILKNQNVISTTTTTTTTTTITKKKLISNDCNNDDNSSGGSGGGMES
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion. Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons.
Sequence:
MNVSFSTPVQNSTASRLALIQQAAARSGALPPAGQYRGSKLSPFDVSQMSGVSISMVERAKINGPEFVEELEWLRQQTTSRCFLDAEMWTNEILAHLPDKWCAPNTLNLYNQVSELVLDNTRSPMASPASNSLYAPGEDQMPTVKRNHTSRFAQSLIKNKEFRRAAFFLEKTMNGNKLDHFLHFRCLFLAYYQEHLENDAEGIERKTSFAEERSPFSLLYQRMEDKKLRENEDVWFEYLMGLLEVELGLKDLAEKSFRNVVIREPRIWPAWEALSRLIADIEDADKFVTSAEVKSLWMGDWFMTLVLQRFHQHSMAIQKAEQLVTRGMTGLPMIITKIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCIVANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFEVFLVVYELVTSAEEKIIYAIAFLANHFFKIEDFDKASEYATKCLAFETLCQEGNRLFREIAKIQARESRLPVEEAPGPSNASAAGGQEAMDTEEAPQEGGEEEMSEGEDDFSF
The following text describes a protein:
Function:
Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.
Sequence:
MVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRLCSEMEELAEHGIFLPPNMQGLTDDQIEELKLKDEWGEKCVPSGGAVFKKDDIGRRNGQAPNEKMKQVLKKTIEEAKAIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPPYDPIRMEFENKEDLSGTQAGLNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQRGQGAPAREPIISSEEQKQLMLYYHRRQEELKRLEENDDDAYLNSPWADNTALKRHFHGVKDIKWRPR
The following text describes a protein:
Function:
May play a role in cell-cycle-dependent microtubule organization.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cell projection, cilium. Note=Associated with mitotic spindles.
Sequence:
MLFPLQVAAVTSSVRDDPLEHCVSPRTRARSPEICKMADNLDEFIEEQKARLAEDKAELESDPPYMEMKGKLSAKLSENSKILISMAKENIPPNSQQTRGSLGIDYGLSLPLGEDYERKKHKLKEELRQDYRRYLTQGITQGKRKKNFLSTSETDPSTLGVSLPIGERLSAKERLKLERNKEYNQFLRGKEESSEKFRQVEKSTEPKSQRNKKPIGQVKPDLTSQIQTSCENSEGPRKDVLTPSEAYEELLNQRRLEEDRYRQLDDEIELRNRRIIKKANEEVGISNLKHQRFASKAGIPDRRFHRFNEDRVFDRRYHRPDQDPEVSEEMDERFRYESDFDRRLSRVYTNDRMHRNKRGNMPPMEHDGDVIEQSNIRISSAENKSAPDNETSKSANQDTCSPFAGMLFGGEDRELIQRRKEKYRLELLEQMAEQQRNKRREKDLELRVAASGAQDPEKSPDRLKQFSVAPRHFEEMIPPERPRIAFQTPLPPLSAPSVPPIPSVHPVPSQNEDLRSGLSSALGEMVSPRIAPLPPPPLLPPLATNYRTPYDDAYYFYGSRNTFDPSLAYYGSGMMGVQPAAYVSAPVTHQLAQPVVNTVGQNELKITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIREREERRKKEREEKEEYEAKLEAEMRTYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDARTYEDKRAVVSLDPNLATSNAENLEDAANKSSGHMQTQSSPFARGNVFGEPPTELQIKQQELYKNFLRFQIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKLQRPPSVDSIIRSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQLRSEERRLQERLLHMDSDDEIPIRKKERNPMDIFDMARHRLQAPVRRQSPKGLDAATFQNVHDFNELKDRDSETRVDLKFMYLDPPRDHHTLEIQQQALLREQQKRLNRIKMQEGAKVDLDAIPSAKVREQRMPRDDTSDFLKNSLLESDSAFIGAYGETYPAIEDDVLPPPSQLPSARERRRNKWKGLDIDSSRPNVAPDGLSLKSISSVNVDELRVRNEERMRRLNEFHNKPINTDDESSLVDPDDIMKHIGDDGSNSVATEPWLRPGTSETLKRFMAEQLNQEQQQIPGKPGTFTWQGLSTAHG
The following text describes a protein:
Function:
Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
Sequence:
MIERYSREEMSNIWTDQNRYEAWLEVEILACEAWSELGHIPKADVQKIRQNAKVNVERAQEIEQETRHDVVAFTRQVSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEKDLERFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEIEVGKMSGAVGTFANIPPEIESYVCKHLGIGTAPVSTQTLQRDRHAYYIATLALIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRGYITTAYENVPLWHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNIDKTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITSVLTKEELDECFDPKHHLNQVDTIFERAGLA
The following text describes a protein:
Function:
Could be involved in fluoroquinolones efflux.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSYLMGLAVFGLASLVCAAAPSMQILVAGRTLQGIAGGLLAGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGPATGGLFAQLGLWRWAFGVMTLLTALMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNYLVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKWIYLTMSVQMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSARVIGHVVAAAPLVMASGLALGAVTQRADAPVGIIALWALALLIIGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGAFGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIASYQATHRDRRLPR
The following text describes a protein:
Function:
May regulate transcriptional activity.
Subcellular Localization:
Nucleus.
Sequence:
MAATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis.
Sequence:
MEQLGALNPWSMTSAVESDERCLEGASNCEGIARYLAAHLSERSYVLGGKKAEEFFQGLGRVWASLATSFDPSAKDTSRYASEDSRIQLALGLAKMERNLVAGLLPFQIEAFKHEPEIRRFIFNITTFVRIEDCRFFTIHSIATQLLSNVLAPVDSSKAATRHADAALRIYVSGNREDDVIIRLLDSRDPKTNHATLHLLNNLTRNSLPRLELLLTPTGMRWLAQLLGRMDEWLDKEHNCFDLATSIFTSIISFSLHPRLFQLLSEPPEPITPSQTVFLKILDSTLSSLPTSSPTPPVENYPNSFLHPLFNSLIQSSLPSLAQKSDDPRLPKYLEGLVLVSEALGTIGLRVQERIDKAAAPAADREDVELQMQGGEEQLIKATKEPLSGIVRPLIDMLRALNDFFPRTNPRNPSPPTATTTIQPELKPFSNLKRDLVRLLGVLTFNDTRVGDQVREYEGVQLVLSLTEIDEGNPFLREHALFCIRNLMLNNPANQAIIKEMDPVGVLSETGELLPVPDKMKKKSIESTITEEK
The following text describes a protein:
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MADAAAATVPGEASSSSSAAATTTVLDSLGEDITRIVTPVSTCMLLVVLLVSLLSSPSSPSPFTAAFSAAAGPGGGGDDITTALITAVTFVVAVTAATFLLAFLFYLRCTPCLRAYLGFSSLSVLLLLGGHVALLLLSRLRLPLDAASFALLLPNAAAALALAALSPASVPIALHQAALVAIAVLTAFWFTLLPEWTTWALLVAMAVYDLAAVLLPGGPLRLLLELAIERNEEIPALVYEARPVDPRHGHNWRLWRERTQSGAELDANSTVEVLGEVLGTNLGASSAGNLGVSAIRSDERVGLAGDARNLRLGTSMPNLSSDSASAQVEVLPASPEISVSVPEMRVPLIQPRPERTRDEEDDEDGIGLSSSGAIKLGLGDFIFYSVLVGRAAMYDYMTVYACYLAIIAGLGITLLLLAFYRKALPALPVSIALGVVFYVLTRTLLETFVMQCSTNLVMF
The following text describes a protein:
Function:
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Sequence:
MKGWLLDTNVISELRKKNCHPAVKAWADRQSPTSFYLSTITMAEIRFGIEKAEDEAFRQELNQWLDQVLRPWFGDRLLGVDEDVILQWRWLVEKGRKQNYTFSQPDLFIAAIAVVHDLCVVTRNVGDFEKSGVPVFNPFLFAQ
The following text describes a protein:
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions.
Sequence:
MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQAGDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSAIFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKPETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRGIGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLSYASLYLWRSIE
The following text describes a protein:
Function:
Receptor for the hormone galanin. Receptor for the hormones spexin-1 and spexin-2.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNASQQIHVFSSHWKVESVIISLIFSMIFLVGTVGNCLVLAVLIRNGQMNTKSTNLFILNLGLADLCFIVFCVPLQATIYTMDEWVFGAFVCKAVHFIIYLTMYASIFTLAAVSLDRYLAIRYPLRSRETRTPRNALTSISLVWALSLFFSSPYLSYYQQMDLDGTTVCIPAWSVHHRQAMDICTFIFGYLIPVLILGITYARTIRYLWTSVDPMQDMSESRKAKRKVTKMIIIVAVLFCLCWLPHHLVILCMWFGHFPLNHTTYVLRILSHLVAYANSCLNPIVYALVSKHFRKGFKKVFGCAFRNRVVNRIHTVQPAQTVSLMEAASSEGSNHCDGSTRGRLWSKSSKKMMTSAFMTFNVT
The following text describes a protein:
Function:
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYNEILGLVTFIATFVLMVLMYRFFGKQGLIAWVAIGTIIANIQVIKTVEIFGISATLGNVMFASIYLATDILNDIYGRRVAKRAVWLGFSSTLIMIIVMQLSLHFIPAPEDMAQKALHAIFDVVPRIALGSIVAYIIGQHIDVFIFSLIKKVFSSDKTFFIRAYGSTFLSSIIDTALFVAIAFIGSLPGTVVFEIFITTYVLKLASTVFNVPFGYIAKSFYRKGKIDKLDQGY
The following text describes a protein:
Function:
Involved in recombination ability and DNA strand transfer activity.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MDSQLVLSLKLNPSFTPLSPLFPFTPCSSFSPSLRFSSCYSRRLYSPVTVYAAKKLSHKISSEFDDRINGALSPDADSRFLDRQKALEAAMNDINSSFGKGSVTRLGSAGGALVETFSSGILTLDLALGGGLPKGRVVEIYGPESSGKTTLALHAIAEVQKLGGNAMLVDAEHAFDPAYSKALGVDVENLIVCQPDNGEMALETADRMCRSGAVDLICVDSVSALTPRAEIEGEIGMQQMGLQARLMSQALRKMSGNASKAGCTLIFLNQIRYKIGVYYGNPEVTSGGIALKFFASVRLEIRSAGKIKSSKGDEDIGLRARVRVQKSKVSRPYKQAEFEIMFGEGVSKLGCVLDCAEIMEVVVKKGSWYSYEDQRLGQGREKALQHLRENPALQDEIEKKVRLLMLDGEVHRSTPLMSSSSSSASHREEEEEDSLDDFQ