lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Single-pass type I membrane protein.
Sequence:
MASLTGVGLWLLVMLPVFQKQVEARENVQLMRQKREWIIPPVKVPENEDYTKKEYIAKIRSDHESVKKVFYELRGKGADQEPFHIFVVDRNTGNIRVTDILDREDIAFYNLTGVAMDAFGNIVETDIELRIAVEDKNDCFPVFKENQMGKVEELSKAGTFVMQVIATDDDDPATDHAKIKYSIVSQSPPEPQMFYIDEDTGMVYAKTNTLDRETVDTYTLVVQGRDLNGKITGNVGQGTVKIQVLDVNDNVPTLEKDEYSASVEENTANVEVMRLKALDKDLEFTDNWETEFDIVSGNEAGYFSIVKDSHTNEGVLMLNKELDYETMQNLNLAVAVRNKAEYSGAGAVGFGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGFGSGKTYPIKIQVKNQPEGPRFSPKVKAISVSEGKKTLNISNVIAKYPAINGDTGKPAERVRYAKAYDPDNWLSIDEKTAEIKLNKLPDRESKHLTNGTYYAKILVMTDDMPSKTATGTIALQVEDHNDHCPVLTSTSQVLCTKSKAVFVTAEDGDADPNGPPFDFKIIPEGTKGTWRVEKLNDTTAILRAQENLWPGPYEVAVEVKDQQGLSCPDKQVVKVDVCTCKNNEDNCASVRKTTGAEFGPAGIGLLLLGLLMLLLVPLLLVFCSCGGLGVGGKGGAFLDMPFDTKEHLISYHTEGQGEDKAVPPLEAYQGGFVPGVGMLAAGSRGSQTAIAGEGVFGNGQRTIRKTAGFGVNAETDGRALGDMSYQRNSSIRNSRSEVRESYHDGIALPDAYLEEYYMQKSMCVAEEDQIQKDGLLIYDFEGRESPVGSVGCCSFIEGDDDLEFLNDLGPKFKTLAEICTSKEMKSEVLVPPAMPTVQDVAVTRTEIKRENTVTTDAVRPQPSPVPQPQIQKNIVTEQYSSTTLPAMHLRENVVVPSPAYVIQQPVYYTTTPAVQPTRYIVEPQVHNTVLFSERPAAPNVQGVLLMNEGSGSEKVLVQENRVVSGSAVQGGVLGYLHGTLNRSEIPGSQNVVLVERKAGSGQYMQEGFTGSNQGTLHRVGLPGSQNVMLVXRKAGSGQFVQEGITGSNQGTLHRVGLPGSQNVVFVEKKAGSGQFVQEGISGANQGSMHSVGLPGSQNLVYREKTVSSSSGAQGGMMNGGSFYMSDLPGSQKVIMKEKIDSR
The following text describes a protein:
Function:
Transcription activator. Binds the promoter core sequence 5'-GGNCC-3', especially at sites IIa (5'-GGGCCCAC-3') and IIb (5'-GGTCCCAC-3') (essential for meristematic tissue-specificity expression) of the PCNA gene promoter. Can target the TCP motif 5'-TGGGCC/T-3'.
Subcellular Localization:
Nucleus.
Sequence:
MEAQAQDKAEEGEEEGTRQQHAQAGPVGAAGGGGGGGAAAVAMSAIPMNSWLVPKPEPVEFFGGMAMVRKPPPRNRDRHTKVEGRGRRIRMPAACAARIFQLTRELGHKSDGETIRWLLQQSEPAIIAATGTGTVPAIATTVDGVLRIPTQSSSSSGPASSAVVDGEESSAKRRRKLQPTRAVAGASPLATAAPAAYYPVIADPLLQGSGGAAISVPSGLAPITATGAPQGLVPVFAVPATGSPAVAGGNRMIPQATAVWMVPQPAGAAGAGNQPTQFWAIQSAPQLVNFAGAQFPTAINVADFQQQQQQQPVSTTIVQNSNSGEHMHFSGADSHEQQRRGRKEGNSGGVVDHPEEDEDDDDDEPVSDSSPEE
The following text describes a protein:
Function:
Transcriptional activator that mediates auxin signaling to promote lateral root development. Activates the expression of two downstream auxin-responsive genes, DBP and AIR3.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA-binding domain and a dimerization domain.
Sequence:
METEEEMKESSISMVEAKLPPGFRFHPKDDELVCDYLMRRSLHNNHRPPLVLIQVDLNKCEPWDIPKMACVGGKDWYFYSQRDRKYATGLRTNRATATGYWKATGKDRTILRKGKLVGMRKTLVFYQGRAPRGRKTDWVMHEFRLQGSHHPPNHSLSSPKEDWVLCRVFHKNTEGVICRDNMGSCFDETASASLPPLMDPYINFDQEPSSYLSDDHHYIINEHVPCFSNLSQNQTLNSNLTNSVSELKIPCKNPNPLFTGGSASATLTGLDSFCSSDQMVLRALLSQLTKIDGSLGPKESQSYGEGSSESLLTDIGIPSTVWNC
The following text describes a protein:
Function:
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus.
Sequence:
MASSGGGGGAGGGGGGGGGNAGDNPIRRFRLQRESELRIEVGWEGSLKVQLLSGSAEIFGTELPPAVWMTFPPAHKIAIFTWSGATVELDGVSEVAYIADETPMVSYVNVHAVLDNRRIKAREAGTNSTPPAGSQRTESNAAPGQGPRVIVVGPTDSGKSSLTRMLLGWAARKSWKPTYVELDIGQGSITIPGTIAATPIEMPVDPIEGVPLEVPLVYFYGHTTPSVNTDLYRALVKELARTLELQFAANADARAAGMVINTMGWVEGIGYELLLHAINTFNADVVLVLGQEKLYSMLKDVLKDRSGVEIVKLYKSGGVVNRNSKYRSRTRVLKTKEYFYGPANDLSPHASVSNFSDLQVFRIGGGPQAPRSALPIGAEPTADPTRVVPVSISRDLMHAVLAVSYAKDPEHLLGSNIAGFIYVTDVDIPRRKITFVAPCPGPLPSNLLLAGSLAWVE
The following text describes a protein:
Function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKTVGEVVAMLDSSIHVDAFRDVVITGVCFDTRQIKSGDLFVPFVGNVRDGHEFVGQAREMGAVATFWQKNVPNPPTDFPVILVEDTLLALQELAAKYIQQVKPKVIAITGSNGKTTTKDIMAAIVETTYKVHYTGGNFNNHIGLPYTILTMPEDTEVAVLEMGMNHRHEIEVLSKIAKPDIAIITNIGEAHIEYLGSREEIAKAKLEITAGLNPSGILIYPHEETLLLGNINGDFRQLTFGKSEAAEIYPLEIRAEAEGTSFITNWEPELEIFVPIIGEHNVFNTMAAMLAAREIGIEGEKIQSALKNMERSKSRLEWITTKSGARILNDAYNSSPTALKTVLKTFMHMDSSGKPKYLVLADMLELGDLSTKLHQESAEVLENDTIQKVFLYGDAMKAFGEVAESKIGQGKVHHFDTKESLETALLSEIKGNEWILVKGSYGMGLKDVVENLIIK
The following text describes a protein:
Function:
Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney.
Subcellular Localization:
Cleavage furrow. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Midbody, Midbody ring.
Sequence:
MAAKGAKETLVNKLGFKSSSSSSKSAELEVEKLKRENQQMKKSLEDMKRAGRHQHTHPDTDKARLLERILALETLREKNNQQLLGREQEITTLRQQLRSAHGEVVSSLQSQLENKQHEAEQRERQYQALVKETEDLKNKYCAVSERCDTLEKQKGSSGELAVVQEQLRDALEKNQHWLVYDQQREAYVQGVLARIKDLEAQLNEANQALQQQHKEAKSDDQSAQKVQQELEAERNKVSRMQMEVEDLQVRYEEKSREAAQAREQLLEERRREREDRKSSVERDALLQDQHRKREAELIMQVNLLQKSLMNQKEEQKRMAILEQQIQLSAKESENEKLDRQTLQHQLHKVLKELRKARDQITRLESSQQRESRFSEPSSYNRMDLERLTIQDHMTSPSKVHNILDESVLECPNCGASYPTSQHRELLAHLDYCFT
The following text describes a protein:
Function:
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Subcellular Localization:
Secreted. Endoplasmic reticulum. Lysosome. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes.
Domain:
Binds cholesterol in a hydrophobic pocket; there are no hydrogen bonds between the sterol and the protein.
Sequence:
MHFLAAAFLLLTLSASALAEPVHFRDCGSGVGVIKEVNVNPCPTQPCQLHKGQSYSVNVTFTSNTQSKGSKAVVHGIVMGVPIPFPIPDPDGCKSGINCPIQKDQTYSYLNKLPVKAEYPSIKLVVEWKLQDDNDQCLFCWQIPVQIES
The following text describes a protein:
Function:
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI to transfer oxidizing equivalent. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MGKGAIKEEESEKKRKTWRWPLATLVVVFLAVAVSSRTNSNVGFFFSDRNSCSCSLQKTGKYKGMIEDCCCDYETVDNLNTEVLNPLLQDLVTTPFFRYYKVKLWCDCPFWPDDGMCRLRDCSVCECPENEFPEPFKKPFVPGLPSDDLKCQEGKPQGAVDRTIDNRAFRGWVETKNPWTHDDDTDSGEMSYVNLQLNPERYTGYTGPSARRIWDSIYSENCPKYSSGETCPEKKVLYKLISGLHSSISMHIAADYLLDESRNQWGQNIELMYDRILRHPDRVRNMYFTYLFVLRAVTKATAYLEQAEYDTGNHAEDLKTQSLIKQLLYSPKLQTACPVPFDEAKLWQGQSGPELKQQIQKQFRNISALMDCVGCEKCRLWGKLQVQGLGTALKILFSVGNQDIGDQTLQLQRNEVIALVNLLNRLSESVKMVHDMSPDVERLMEDQIAKVSAKPARLRRIWDLAVSFW
The following text describes a protein:
Function:
Receptor binding protein (RBP) that is at the tip of the long tail fibers and serves as the phage recognition site for the attachment host receptor (By similarity). Probably uses the host receptor OmpA (Probable).
Miscellaneous:
MISCELLANEOUS: This phage use outer membrane protein ompA as a receptor.
Subcellular Localization:
Virion. Note=Forms the distal tip of the long tail fiber.
Domain:
The N-terminus is involved in binding to the fiber protein p37. The C-terminus contains glycine-rich motifs (GRM) and mediates the host specificity. The glycine-rich motifs assemble into a 3-layered PG(II) sandwich domain.
Sequence:
MAVVGVPGWIGSSAANETGQRWMSQAAGQLRLGVPCWMSQFAGRSREIIHTLGADHNFNGQWFRDRCFEAGSAPIVFNITGDLVSYSKDVPLFFMYGDTPNEYVQLNIHGVTMYGRGGNGGSNSPGSAGGHCIQNNIGGRLRINNGGAIAGGGGGGGGGYWNASITRYRYRYVVGGGGGRPFGAAGGYSGGSASTAGTLTGAGIGSKPGNAIYGGNGGNVGSAGGAFGGISGSRYGGGAAGYAVIGSAPTWQNVGAIYGPRV
The following text describes a protein:
Function:
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MTFQKQRRMDCSILCLLIFTLLLNHVHASKKCYIVYLGAHSHGPTPSSIDLETATSSHYDLLGSIMGSKENAKKAIIYSYNKQINGFAAILEEEEAAQIAKNPKVVSVFLSKEHKLHTTRSWEFLGLRGNDINSAWQKGRFGENTIIANIDSGVWPESASFNDRGIGPIPAKWRGGNICQINKLRGSKKVPCNRKLIGARFFNKAYELVNGKLPRSQQTARDFYGHGTHTLSTAGGNFVPGASIFGIGNGTIKGGSPKSRVVTYKVCWSQTIADGNSAVCYGADVLSAIDQAISDGVDIISVSVGGRSSSNFEEIFTDEISIGAFQAFAKNILLVASAGNGGPTPGSVTNVAPWVFTVAASTIDRDFSSTITIGNKTVTGASLFVNLPPNQSFTLVDSIDAKFANVTNQDARFCKPGTLDPSKVSGKIVECVGEKITIKNTSEPVSGRLLGFATNSVSQGREALSAGAKGMILRNQPKFNGKTLLAESNVLSTINYYDKHQLTRGHSIGISTTDTIKSVIKIRMSQPKTSYRRKPAPVMASFSSRGPNQVQPYILKPDVTAPGVNILAAYSLFASVSNLVTDNRRGFPFNIQQGTSMSCPHVAGTAGLIKTLHPNWSPAAIKSAIMTTATIRDNTNKLIRDAIDKTLANPFAYGSGHIQPNTAMDPGLVYDLSVVDYLNFLCAAGYSQRLISTLLNPNMTFTCSGIHSINDLNYPSITLPNLGLNAVNVTRIVTNVGPPSTYFAKVQLPGYNIVVVPDSLTFKKNGEKKKFQVIVQARSVTPRGRYQFGELQWTNGKHIVRSPVTVQRK
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MSAIYQRARPIRWEDVVGQEHVKDVLRTALEQGRIGHAYLFSGPRGVGKTTTARLIAMTANCTGPAPKPCGECESCLAVRAGSHPDVMEIDAASNNSVDDVRDLREKVGLAAMRGGKKIYILDEAHMMSRAAFNALLKTLEEPPEHVIFILATTEPEKIIPTILSRCQHYRFRRLTSEEIAGKLAGLVTLEGASADPDALNLIGRLADGAMRDGESLLERMLAAGTAVTRPAVEEALGLPPGERVRGVASALLVGDAGEAISGAAQLYRDGFAARTVVEGLVAAFGAALHAELGLGEEGRLEGAEVPRLLKLQAALDEQEARFARSADQQSLELALTHALLAADGGTGGGAPSLGSAATSAPAQVPGDLLQRLNRLEKELSTLRSAPRAAAPASAVPAAPAEKRGPAPAREAVREAAASIAPAAAPTQGSWADVMAQTTMQMRAFLKPARMHAQDGYVSLTYEDRSSFHAKQVAGKFDELAALVERVFGPITFELIAPEGLGRKREAGRAGGSQAAASAPAPTLNPAPTRSTPAPKADAPVEIPDFDPSPRRSRRGPEFEPVTVGAAQPQPVAAAQTASTQTPGTQTASAPPPSLPPRPPARPSGTRPCACGPAT
The following text describes a protein:
Function:
Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons. Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation. Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9. Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway.
Subcellular Localization:
Cell projection, dendrite. Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Nucleus. Perikaryon.
Sequence:
MKDVDNLKSIKEEWVCETGSDNQPLGNNQQSNCEYFVDSLFEEAQKVSSKCVSPAEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSELQGIFDKEEVDVKVEDKKNEICLSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNNLSAVPLNNLEPITNIQIWLANGKRIVQKFNISHRVSHIKDFIEKYQGSQRSPPFSLATALPVLRLLDETLTLEEADLQNAVIIQRLQKTASFRELSEH
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MSEVRHSKRLLAKSNKVNVSPQKKQQTKVAKAPKTQTTTKRKNKSSDAKENIRKTPENIVDSSQTDDSSDIDSEDEDFYQKIQNQRRKLEQEKLKIIQDLNLHQAALDLQSSLKSNSGARRKTEKREAGVPVRKSRRLQNIKPEDKDKEGWSASTEVSEPKAQRVTDQEHKIDPVVKETTTKKNSDPEETNNNKESSKYTELIEIFKSELKLKFPDENLPVDSFTKKLESNTSSQCVVEKVVQSRIYAIDIYPSHSDIIMAAGGREGDVGIWNLDTSYKGDDKASIFSFFPHSSPVKCLRFAPDAPHKLYSCSYDGMFRCTDLTSETVSKAIHDDETYPPMYFDFIGKTSQSFILAKYGGDVMLCDTRESEDKFKTYGTGMRSLRGVSVHPVDSHYFAVSGNDKTLGSALIFDMRKLLRKASHPVVTLHGHKKAANSAIFSPITGNKLVTCCYDDRLRVYNTSVIGESASKPCVSIHHNNHTGRWLAPFQPAWHPTRDDIFVMGSMHKPRQVEIFDSDLQLQCVLNDTEVMKSVCSLNRIHPSRDVVVGGNSSGRVFIFGQ
The following text describes a protein:
Function:
Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates G-protein alpha subunit goa-1.
Domain:
The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).
Sequence:
MRSVRSSSRTPKPVKRFVFDEDEDLEEIDLDEVDNADFEREDDEEEVLSEPSESPYTSTPKSSKRVNKTRGTKDFFKKDESLQLFRFVLNECRSQKPGRVGRVAKKRVGVNSMKYWERYKREIQGYRLPKQYRYHYSFYSKCFYKVLGLTPEEKVDLYYACEMPVVTDAEKQWLVEQFHVEFDEFGVIIGSDVCTHWDEEHSDSEDDSGKKEEKAREVSRYTEYHDDMMWKFIVDKISEGAQPIIDKHPIWDEFVKLNEENDVISKKSGRNHYDRFRRILVPNLHFMPYDDFTKAVLYERLEYPIPEEYRKILFTTTGADINESGFIEYLPPSTIHQISPIVPIPCHKSNPKFSQLKEPKDLILWSERKKFTPREDSQIWEFVRRKCVDSAGIFVKNDVLRGRGTLFFKDFRNTERKYESITQRFVVLRKLIMDTDYSLKQKLEIYYAISQPVDEDALDAFKSIACLVLNPDGTIRFAISKSFLIGRISDEPAKLEAENYSYVYDLFIFNETFGTAENPEPLCSVSQNRAEKFMLVSQLVFRFISRFEALEDRRIAWITPNAQVAPKEPVPAPSKKKSAFEAYQSSPQTFDTIQRFSTKRPFFCGDNFQIPPKKPFLAEEDVKLEPMEYENSEQIVENAEIKLEPAEELLDAETVTVEEFLMNSYSTAAPSTSTAPAPPKAPVTAPPAPQKSAQLLGKIDFAIGKMRENFDRFLQFAQQNSADLTVVQRYRYDAQMQQMTEKFTKDVSKVLSGDSIKR
The following text describes a protein:
Function:
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.
Sequence:
MAPSKARQKRSLPQITTIAGTGPIANSQPASSTLTKEVDQQEEQCLKEPKIPPLPPITVNVVPQQGLGCEVVEGLLVPSRKREYKSNGKYTVGNHPIYAIGFNFMDVRYYDVFATASSNSVTVYRCLENGSFGLLQAYVDEDKDESFYTLSWTINKVDRKPLLVAAGNNQIIRIINCAGEKLAKSLVGHGGSIHEIRTHASKHSLIISASKDESVRLWNVHTGVCILIFAGVGGHRHDVLSVDFHPTDVGLFASCGMDNTVKIWSMKEFWVYVEKSYSWTDNPSKFPTRHIQFPVLSAAVHSEFVDCTRWLGDLILSKSVENEILLWEPKPDKNKPGEGSVDILQKYPVPQCTLWCMKFSCDFHFNQLAVGNSKGEIYVWEVQSCPPVLIDRLSNKECKSPIRQTAVSVDGSTILGAGDDGTIWRWDEVSPSTSKTKPIQAAVATDANA
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MIVNFKTQRVIQNFSKFLLSLNAITDSGLSILNMTEVDENFDSRFSCNSREYEYWILNTKYPRPTWKNRTFWYQHRIDVPRLEAELELLKGEHDFRSLAKVASLKGRSTVRTILDVKLERSLELEGLLKVKIRANGFLHNMIRILTGTLLEISNGKRKDTNVLEILSSKDRTIAGITLPPYGLYFIRAYYDSYPKIDFMYSHLDFLK
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTIFDSDEEELVTTLSDFEPPVQIDTSFNKFIVVDNIPVAPEAKHEKLKSILVKIYQNRPGAEVVGIHLALDAQRNTKGFAFIEYSKKESAIDAATSLNNYPLDKSHTLKVNLLDDFSKFANFEETYKPPTREDFKPKPNYNQWLSDPKALKGYDQFVTRYGDYTDICWNEMHVGKPMVEKSSVSLTSSYVQWSNTGSYLVTFHPDGIALYGGKDWIQVNLFEHRGVQLVDFSPEDKYLITFAPIASDNPNSPKSIVVWDVRSGKKLRSFLAPPKEQFTWPAFQWSAKDKYIARIEQLEKGINIYETPSMNLLDDKIFEVKGIKDFSWSPTDLSLAYFVPANDPLPAKICLVEMPSKKLLAEKSIWGATDARFHWQNEGAYLCVKTDKVATGKTKKEKIPTTSFELFRTHEPNVPIESFEIQYAIKAFSWEPRGKRICIIHGEFKMNMFVSFFEVQKTSVKLISKLENRKLNTIFWSPRGTLVLLANLGDTGELEFYNTQDCESYGTQEHLQCTGVDWNPSGRYVTTFVSHWKVQTDTGFNIWSFNGDLVYSVLKDRFFQFNWRPRPKFMLTNKEINQIKQNIKKYQEKFDKQDEDDNKAIQHIEQTRLDNLMKEFLSFLQKGEQEYQALEPTRKQLGSYEDIDPNDIYESIETIEELIDIKTIVLKKIN
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MFTVYHSNQLDLLKALTTALIEREPLDNPFQQEVVLVQSPGMAQWLQMQLAQQFSIAANIVFPLPATFIWDMFTRVLPDIPKESAFSKEAMTWKLMWLLPDLLENPLFSPMKRYLSDDGDRRKIHQLAARVADLFDQYLVYRPEWLESWERGQLIEGLDDAQQWQALLWVELTRYTRQLEQPEWHRANLYQRFIHQLLKSDVCPQGLPKRVFICGISALPPIYLQALQALGKHIDIHLMFTNPCRYFWGDIQDYTFLAKLQSRKRRHYRESIELSLFRHPQQAEQLFNTDGEQNLSNPLLASWGRLGRDHMYLLSQIDEIQEVHAFVDIEPDNLLHGIQHDMLELEDHAVIGTTPETLARSDQKRRLDLDDRSLSFHVCHSPQREVEVLQDHLLGLLAADPELTPRDIIVMVVDIDSYTPYIQAAFGNAPSERYLPFAISDRKASQAHPALHAFITLLDLPQSRFTAEQVLALLEVPALATKFGITEDGLRRLRQWVGESGIRWGLDDDNVRELSLPATGQHTWRFGLTRMLLGYAMDSTAGDWQGILPYDESSGLAAELAGQLADMLMHLSQWRQQLGQPRELSEWLPICRQLLDTFFDQDNDTEAALVLIEQQWQKVIGYGIAAQYPDVVPLNLLRDELAARLDNERISQRFLAGPINFCTLMPMRSIPFKVVCLLGMNDGVYPRTLPPQGFDLMAKKVRRGDRSRRDDDRYLFLEALLSAQQQLYISYIGRSIQDNSKRYPSVLVSELIEYVAQSYHLPGDEKLSADDSAQRVTQHLLCWHARMPFSAENFIKNSELQSYAAEWLPSAESKGHAHPNFNQPLQAEPLAEITLDELVRFYRHPVRAFFQLRLGVNFVIEETELPDEEPFTLDNLSRYQFNTQLLNALINEDDINSVFARARAAGVLPYGSFGELYWESQQDEMVPLAEQIRSERKENHSIELNIEFADITVTGWIHQVQDDGLVRWRPSILTAVDGLLLWLEHLVYCSAGGEGESRIYGRKGTAWRYAPMAADEARPYLQQLIKGYQQGLCEPLMLLSKSGWAWLSQCFDRESGQILWDEETQGKARMKLLQVWQGDQRVTGEGEDHYIQRVCRRMDNQHLDIILHETERYLLPIARHNKA
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEEESITDAADCEGGMPDDELPADQTVLPGGSDRGGGAKNCWQDNVKDNECDSDAENEQNHDPNVEEFLQQQDTAVIYPEAPEEDQRQGTPEASSHDENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLMPVNGRPRSGLKTSQCSSPSLSTSPGSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFSSGGQLQATSSPQGVVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLETNQASLASKEQEAVSASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKEIPAPTNSCKSEKLPEDLTVKSETDKSFEGARDDSTCLLCEDCPGDLNALPELKHYDPECPAQPPPPAPATEKPESSASSAGNGDLSPSQPPLKNLLSLLKAYYALNAQPSTEELSKIADSVNLPLDGVKKWFEKMQAGQIPGQSPDPPSPGTGSVNIPTKTDEQPQPADGNEPQEDSTRGQSPVKIRSSPVLPVGSAMNGSRSCTSSPSPLNLCSARNPQGYSCVAEGAQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSATVSPAVQEPPVKVIQPNGNQDERQDTSSEGVSTVEDQNDSDSTPPKKKTRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICRKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRGAEDRDAMEQEDAGPEVLPEVLATEHVGARASPSQADSDERESLTREEDEDSEKEEEEEDKEMEELQEGKECENPQGEEEEEEEEEEEEEEEEEEEVEADEAEHEAAAKTDGTVEVGAAQQAGSLEQKASESEMESESESEQLSEEKTNEA
The following text describes a protein:
Function:
Enhances the transcriptional activities of several nuclear receptors.
Subcellular Localization:
Nucleus.
Sequence:
METKEEKKERRQGYFARLKKKRQAKQNTETVSANSPGSPVSKTPAEKDDESKVILEQISSSGDNCKFAGEKETVPEKEKRKKKYNQLKDIRRTELKRYYSTDDNQNKTNEKKEKKMVSQKPHGTIEYTAGNQDTINSIALKFNITPNKLVELNKLFTHTIVPGQILFVPETSVARLPSFSPGAPISPSSSDAEYDKLPDADLARKAFKPVERVLSSTSEEDEPVVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYNDISHMKIKDALPSDIPKDLCPLYRPGEWEDLSSEKDINPFSKFKSLSKEKRQQNGDSPNVPGAKQINPSDKEKSADFEVLQSSESTGSIKSKSLEFYNNITATEHLEKFAADPHVKEPSEEKNVSDIRTKEDSLSGGGDDFIDLEKVPSPMDRGLDRKISLMEGLLADPRELGRTKQQVTKPTTEVQEHFTVDSLEKKDSVEPKADLDLELCEKQDVIPEVNKCVSSPTGKVETALDTKKELEKDKLIEFYLNKDGSGSQSSEDLHKAEIQKGENNKAIGIDLTLSCSKSQADEVHTVKSMELDSCCVGRKAASLESSAAAAEEKDLKESLDSSLVPAVDKTCQETQLDNQSEVRLWLLQKIQVPIEDMLPSKEEKSKTPPMFLCIKVGKPMRKSFVSQSTTVSQQYSKKIKQPEYWFAVPREIITVEEAKRRKSVCSYYGEEDDDDALPVLKHHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFRFSDHYYGTGETFLYTFSPNFKVFKWSGENTYFINGDMTSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFIIQDVEVWTFE
The following text describes a protein:
Function:
Probable GTP-binding protein that may be involved in cell development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEESDAAEGVAVQLIDGEGEFAAAAAERFMAAAGVAGCGLSYAVVSIMGPQSSGKSTLLNQLFGTNFREMDAFRGRSQTTKGIWIARCVGVEPCTVVLDLEGTDGRERGEDDTAFEKQSSLFALAISDIVLINMWCHDIGREQAANKPLLKTVFQVMMRLFSPRKTTLLFVIRDKTRTPLEHLEPVLREDIQKIWNSVAKPEAHKDTPISEFFNVQVTALSSFEEKEEQFREQVQQLRQRFSNSIAPGGLAGDRRGVVPASGFLFSSQQIWKVIRENKDLDLPAHKVMVATVRCDEIANEKFGCITSDTEWLDVESAVQSGPVPGFGKKLSNIVEVHLQEYDKEAFYFDEAVRKGKRQHLESRILNLVQPAFQKMLTHLRMKALEKFKAGLNSSLESGKEFAISARDNTECSLKDFEQGCADAIIKQANWDCSKILEKVRRDIEDHALSIRERKLSELTTHAKEKLRKALAEPVESLFDAADQTTWTSIRNIYKRETEAILPEFLKTICGFEMEYAQAEEMVSKLRDYARSVVQSKAKEESSKVLIHMKERFTTVFSHDKDSIPRVWTGKEDVHAIAKEARAAALKLLSVMAAIRWDDEPDRIESIITSTLLEGSVVSKIASAASADPLASTTWEQIPPEHTMITPSQCKLLWKQFKSETEFTITQAVSTQQAHRRGNSKLPPPWAIVAIAILGFNEIMTLLRNPIYVFLLFVGYLMVKALAVQLDVSREFQNGVVPGIISVSAKLLPTIQNLVNKVAAEQQDEHRHPHQQHPQVAEPLQPQMQPPPLLLSPRSPMSELRRLHMPSSPRKVASSSSSPSSSSSSAVSSPRHVGEDQKPRPGAAAPENQSTIADSIV