lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVLDKLLYTGYNVSTECGYCKSGRKTEHFGLLAEKLSCEDYQRLIDLGWRRSGHYLYKPNGKTSCCSLYTIRLDSYNFKIAKEQKKAIKKWVKYVNGKPLKPMKSEISTDYLNNAFQTIESLGAEKYSVTMEPCTYTDEKFEVFKKYQMQVHLEKEEEITKKGFSRFLCNSPLFNEDKGIKYGSYHQMYRFQGRLVAVGVLDLLPHGVSSVYLFYDPDMSKFSLGRISACREIWLALECGYRYYYMGYYIHTCPKMKYKATYSPSYLLNPGTNKWIPIENFTSLWNTGAPKYISFGDENNSDIQTAVDYDSSEDSSQNEDDYTLFNRQLPGILSVNVAESLVSENFANIGNSTFPTRHVLSYFPQVKHWFVEINAAVGEEVAKSYTLVLSS
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Required for both entry into S phase and kinetochore function. Also involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes.
Miscellaneous:
MISCELLANEOUS: Present with 1340 molecules/cell in log phase SD medium.
Sequence:
MPVEKDLKTAYKALYDEKEPLKALHLYDEILKGSPTNLTALIFKAACLEKLYFGFSDWHSDATMENAKELLDKALMTAEGRGDRSKIGLVNFRYFVHFFNIKDYELAQSYFKKAKNLGYVDDTLPLWEDRLETKLNKKNKKQKDSTNKHTIKPVESIENRGDNNSSHSPISPLKIETAPQESPKFKIDWYQSSTSVTISLFTVNLPESKEQVNIYISPNDRRTLSISYQVPKSGSEFQYNAKLSHEVDPKAVSLKIFPKKLEITLSKIDSTQWKKLEEDILTESSRLSDEGKNSDSATRLLSAETASKERLSYPSSSKKKIDWSKLDIDEEADEEAGSADSFFQKLYAGADPDTKRAMMKSFIESNGTALSTDWEDVSKGTVKTSPPEGMEPKHW
The following text describes a protein:
Function:
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. Can complement nadA-deficient E.coli mutant. Essential for the de novo synthesis of NAD. Also participates in cysteine desulfurization mediated by NFS2. Can activate the cysteine desulfurase activity of NFS2 in vitro.
Miscellaneous:
MISCELLANEOUS: The highly oxygen-sensitive (4Fe-4S) cluster at its NadA domain, can be reconstituted by its own SufE domain in the presence of NFS2, cysteine and ferrous iron.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALALSVAPTSSSLSSLLSRTPNPSPNFRTTHLNFGSQRRIYTINPLLRSFKCLQSSSRDVNASPFSISAIASSSSSSQTTELVPYKLQRLVKEFKSLTEPIDRLKWVLHYASLLPQMPESSKTESNRVMGCTARVWLDAELGQDGKMRFCADSDSDVSKGMCSCLIQVLDEASPVEVMELKTEDLAELNVGLLGGERSRVNTWYNVLVSMQKKTRRLVAEREGKVPSFEPFPSLVLTAHGIEAKGSFAQAQAKYLFPEESRVEELVNVLKEKKIGVVAHFYMDPEVQGVLTAAQKHWPHISISDSLVMADSAVTMAKAGCQFITVLGVDFMSENVRAILDQAGFEKVGVYRMSDETIGCSLADAASAPAYLNYLEAASRSPPSLHVVYINTSLETKAFAHELVPTITCTSSNVVQTILQAFAQMPELTVWYGPDSYMGANIVKLFQQMTLMTNEEIANIHPKHSLDSIKSLLPRLHYFQEGTCIVHHLFGHEVVERIKYMYCDAFLTAHLEVPGEMFSLAMEAKKREMGVVGSTQNILDFIKQKVQEAVDRNVDDHLQFVLGTESGMVTSIVAVIRSLLGSSANSKLKVEVVFPVSSDSMTKTSSDSSNSIKVGDVALPVVPGVAGGEGCSIHGGCASCPYMKMNSLSSLLKVCHKLPDLENVYGGFIAERFKRQTPQGKLIADVGCEPILHMRHFQANKELPDKLVHQVLSCESKR
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MLIELQIQDFAIIDRLHLRFEQGFNVLTGETGAGKSIIIDALGTLRGDRVDPTFVRAGCARARVEGVFSLDDCPHLVPLLVEYDLYDEDDGQLILTREMSAESGRSVARVNGRAVNSAVLREIGSRLIDIHGQHEGQSLFNPRTHLDLLDRFGDLLPLRQQVTDQLAALRAVQAQLNDLRTGEARRQARIEELQLLCDDVAAAKLRPGEEEELLRERSIVQNATRIATLADEAYRALYSGGEGRSGRPASEAMALAVDALNELSRFDDRAAPLAQQATELQYQLEDLVIALRSYRSHLDVDPRRLEVIEDRLTVLRDLQRKYGVDLATLIEQAARAGDEIEQLSSATTQIAALEAQEHALLQELARRAAELSQRRKQVGEELSRQISMAMKDLAMPNVQFAVQIDHQDDPNGPLINGRRLACDRNGIDRVEFLISPNPGEPLKPLARIASGGESARLLLALKSILSQVDEVPTLVFDEIDVGVGGRAGHVVGQKLWMISRRHQVLCITHLPQVAAFANAHYHIRKEVVGGRTRTAVEVLSAEQRIDEIAAMLDGVPNDHSRANARQILERAQAWQMHRQAELIPER
The following text describes a protein:
Function:
Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3. Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively; Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MHLLAKPQSSGSREAAWFSSLLLHVCWGLPLARPHSPPGLSPGAHMKMHLQRALVVLALLNFATVSVSLSTCTTLDFSHIKKKRVEAIRGQILSKLRLTSPPEPSVMTHVPYQILALYNSTRELLEEREDGCTQENTEWEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNGTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTETVREWLSRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDSEDDHGRGDLGRLRKQKDHHNPHLILMMIPPHRLDNGGQGGQRKKRALDTNYCFSNVEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSKVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEHLSNMVVKSCKCS
The following text describes a protein:
Function:
Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
Sequence:
MFFFKNISLFPLGKNPFIIIIDILIVSFFIYQFYSTIRRTRGIQLLLGVAVIWFLGIFASTFELELLDWIIESIRPALVFAIIVLLQPELRKITADLSKMKIFQPFLLKQMTDLEEIIEAVKIMAKNKTGSLIAIVRENNLKEIIDQSVQLDAIISASLLLTIFKKNSALHDGAVIIEQNRIACAGAFLPMTQNLDDSRMGARHRAALGISEESDSIVIVTSEETGEISVCYDGEMTHPVKPIELKNLVNTILKKRDNVSEKYNPVVEEKTER
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MPRSVPVMTDVIQVTKRESTGTAATRRLRRDGHVPAVLYGHGEANEHLAVPSAQVKGLLRHHSKTVQLSGDVDETALVSDMQWDPLGIEVLHMDLIRVNLKEKVELGVPIVLHGEAVGVREGGMLLENVHEVEIRCSAGSIPDNLVLEVSELGVGEHKTAGDLTLPEGVELITDVDVVIAHIEAQRDEEIAEAGDALAEPEVISKGSGEADE
The following text describes a protein:
Function:
Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Protects cells against apoptosis by protecting CDKN1A against degradation.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nucleolus.
Sequence:
MGNQDGKLKRSAGDASHEGGGGGAEDAAGPRDAETTKKASGSKKALGKHGKGGGGSGETSKKKSKSDSRASVFSNLRIRKNLGKGKGAGDSREDVLDSQALPIGELDSAHSIVTKTPDLSLSAEETGLSDTECADPFEVIHPGGSRPAEAGVGIQAIAEDLETAAGAQDGQRTSSGSDTDIYSFHSATEQEDLLSDIQQAIRLQQQQQQQQKLLLQDSEEPAAPPTAISPQPGAFLGLDQFLLGTSSEAKKDTVQAPPVRPDLPETTKSLVPEHPPSSGSHLASETPGYATAHSAVTDTLSSPAFTFPEVPEAGPGEGAAGVPPAGTGDTDEECEEDAFEDAPRGSPGEEWAPEVEEASQRLEEEPEEGMRGPIIPAVASLPGSPAPSPRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKKRPDPSVSRSPRTALASAATPAKKHRLEGGLVGGLSRSADWTEELGARTPGAGGSVHLLGRGATADDSGGGSPVLAAKAPGAPATADGFQNVFTGRTLLEKLFSQQENGPPEEAEKFCSRIIAMGLLLPFSDCFREPCNQNAGSSSAPFDQDQLYTWAAVSQPTHSMDYSEGQFPRREPSTWRPSKLPDEEPSPKDIDTAYLEEPQSSILESPKKCSNGVQQEVFDVKSEGQATVIQQLEQTIEDLRTKIAALEKQYPSLDLEGPRLENGLTASADVSLDALGLHGKVAHPPRTLEAKSIQTSPTEEDRILTLPPPKAPPEGLPGPPAAESGESALLTSSSGPQTKFCSEISLIVSPRRISVQLDAQPAMQSTSQLPPPPSLLGADSQGQPSQPSLHPELETSHEHSVFSSFENSCNIPPAPPLPCTESSSFMPGLGTAIPPPPCLSDITVPALPSPTAPALQLTNLQGPQMLPTPPQPPSLSGPGVPPPPPPPPLPGVGIPPPPPLPGMGIPPPPPLPGMGIPPPPPLPGVEIPPPPPLPGGGIPPPPPLPGGGIPPPPPLPGGGIPPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGVVIPPPPPPPPPPLPGVGIPPPPPLPGMGIPPPPPLPGVGIPPPPALPGVAIPPPPPLPGMGVPPPAPPPPGAGIPPPPQLPGSGLPLSSQDGSSTLPAAPQGCGFLFPPLPTGLFGLGMNQDRVARKQPIEPCRPMKPLYWTRIQLHSKRDSSPSLIWEKIEEPSIDCHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHSRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNAGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCVFPLSEPQELFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSEEHKQPFKENMEQFISQAKIDQETQETALTETHKCFLETTAYYFMKPKLGEKEVSPNVFFSVWHEFSSDFKDSWKKENKLILQERVKEAEEVCRQKKGKSLYKVKPRHDSGIKAKISMKT
The following text describes a protein:
Function:
May be involved in sexual development.
Subcellular Localization:
Nucleus.
Sequence:
MDPSETAALHHCSADSSPADEARVPQSTELIPRRPVSRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLAQGLMKGATPLKAPLRVKKGAIRPGIPSGKENIAPQPQSPHGAVPLVLTPPGKENYGPLLLSRPPEALPLPWTPVPPGPWGPGHWLPPGLSMPPPVVCRLLCQEPAVPLHPFPGFDPGTSLRLPTHGTLPTCPGSRSVLTAPLSGEPQGPPNLPHTCSTLILQSCGTPDSLLLQPQAPGASCLAWTSGPSERQLQREAAEALVGLKDSSQAPRLTPSVPPNPAWISLLHPCGPPAPPGGRGFQPVGPPLRPSPGSSVSLHIGRLGSISLLS
The following text describes a protein:
Function:
Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate. When associated with the alpha3 subunit AccA3, the beta5 subunit AccD5 and the epsilon subunit AccE5, forms the LCC complex, which is involved in the carboxylation of long chain acyl-CoA. The LCC complex can use C16-C24 substrates, the highest specific activity is obtained with carboxy-C20-CoA. Has low activity with acetyl-CoA and propionyl-CoA.
Sequence:
MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFMEIGALCRTPGDPNALYGDGVVTGHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQYVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAERGFIDAVIDPHETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV
The following text describes a protein:
Function:
ADP-ribosyltransferase that efficiently ADP-ribosylates both alpha subunits of host RNA polymerase RPOA. The ModA-induced ADP-ribosylation of RPOA alpha subunits inhibits transcription from viral early promoters.
Subcellular Localization:
Virion. Note=This protein is injected from the virion into the bacterial cell.
Sequence:
MKYSVMQLKDFKIKSMDASVRASIREELLSEGFNLSEIELLIHCITNKPDDHSWLNEIIKSRLVPNDKPLWRGVPAETKQVLNQGIDIITFDKVVSASYDKNIALHFASGLEYNTQVIFEFKAPMVFNFQEYAIKALRCKEYNPNFKFPDSHRYRNMELVSDEQEVMIPAGSVFRIADRYEYKKCSTYTIYTLDFEGFNL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLFLRRALSCAVPRRMAQDAMRPSTGTKDAYKSMLAQYYPQELLKSIELGEQAIPDDAEYRLSSNVEFAPPYLDDFSKLDPFWDYKPGLPHQHADGPLTAFRPDQQHQPLPERLEVPRGAALLTTGGSNMAAIARGIARQTGLDAEYITRKLVMRPLVVKRVSNQTAKGKIASFYSLVVVGDRNGMVGLGEGKSREDVSESIKKAHWNAIKNLKHIPRYENRTIFGDIDFRFHGVKLHLRSAKPGFGLRVNHVIYEICECAGIKDLSGKVYKSRNEMNIAKGTLEALTKSQKTLEEIAYSRGKKLVDVRKVYYSSD
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MDVSGEEDHSMCLTRSLSPGFLSVCRYMKCGSDPEFASVGGIARFAKWRWKYGWRRWNVGYRLFMYLCNERLPSVGPSVGSMAQPAEKVEKRSLNSELWHACAGPLVLLPPVGSRVVYFPQGHTEQVAASMQKEVDAHIPNYPNLPSRLVCLLDNVTLHADIETDEVYAQMTLIPVPPTNEKDAHMSPDIEMRSRQPTEYFCKTLTASDTSTHGGFSIPRRAAEKVFPPLDYAQIPPAQELKARDLHDQEWHFRHIYRGQPRRHLLTTGWSVFVSAKRLQAGDAVLFTRDNKGQLQLGIRRQNRQQRVMPSSVLSSDSMHIGVLAAANYAAATSSRFTIFYNPRQSPSEFVIPVAKYQKAICHLQVSVGMRFRMVFETEESSVRRYMGTITGMGDLDPIRWPNSHWRSLKVGWDESTAGERKKRVSLWDIEPLTFPYVLCPQPLAFRAKRPRGGRDEETDSMLKKSSFWSGENSTDALGRLTFRTPSLDSWMRPKQPGLPMQENEHYRALEAAALEEIRTTSTAKNPMSRVQSSIPSSQMQFQPPHVLRQSSQHGELHMPEASGPLLQLSSSRPQSPFEVGINMPQCSGYSEGKIHMASSLSASESFPLHSMLGRTHLGCDTVQVTHVIRPGKSAQQNLSGAAIHGSSAVVRDPQVSPSWYPPNRDLNQYDVSVRMNQLDTSPTSRNPGSFTFPQQGEGIGQSNLAALPAPTSSFMYRESGQAQDLVQSDRRLLFGVSIEQQPLGDSHSVTSRHPQTFVKNKDAQSRFPGNIMLQGSYCPSTTADIPTVGGVVLDKIGVFQRCAPWSIMSPAPMRTFTKVHKLGSVGRSIDVQKFQNYSELRAELARLFNLEGLLEDPQTSGWQLVFVDNENDILLVGDDLWEEFVSCVRSIKILSPNEILRMSREQLEILNPVPMQLRPTCSNSEDARTQLSPANASTMSLEHGHSGAG
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTHSDTDVSHEKRSFKKPTMPNLDSEWLTQVLLYLNLSVFAMAGAIARQGITLLTVFTGSYSPSGLLWCNFGGCIIMGWLEESDIFAVIEEQKGVEKRKIPLYVGIGPGFCGSITSFSSIMLEAFLFGANQNIPKADYPDAGYGVQSVMAIGLIHYSLSFAGLLIGHHIADFLPIPCMSVPFERAVSFVIGCCSIALFCLFIIFAAVWKSWRTWMYLGLWALAGANFRFQFSRMNRLGSGKNPWGTFTSNMIGTIILSVGVILQMGFVGDSQLVTNVVQCQIIGGIANGFCASLSTVSDLVNECYNMSYKRAYVYGWFTNFFGFSLMIVILGSFTWTNSLTAPHCA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGSKRAMDVHMFPSDLEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMGSYGRCMDPCGTCLKLQDCPGHMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRLIDAGYIIEAQELELFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAITHSALQRLGKKCRHCNKSMRFVRYMHRRLVFYVTLADIKERVGTGAETGGQNKVIFADECRRYLRQIYANYPELLKLLVPVLGLSNTDLTQGDRSPVDLFFMDTLPVTPPRARPLNMVGDMLKGNPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAHEKLYTAWLALQMSVDVLLDVNMSREMKSGEGLKQIIEKKSGLIRSHMMGKRVNYAARTVITPDPNINVDEIGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTTYIPADNASKRESLAKLLLSNPKDGIKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCKAYNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFFNREDYQQLVFQGLSQLKKDIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYERINLDSFAKIAGKNWNVSRPRPPICGTNPEGNDLSESQVQIRNGELLVGVLDKQQYGATTYGLIHCMYELYGGDVSTLLLTAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAVAAALELEDEPPHDELVEKMEAAYVKDSKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQLMVLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQPQDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGLDILKSKFFNDKFCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKKKPAKLRAAFTHFSEELREEVEVKRPNEINSKTGRRRFDEGLLKLWKKADAEDKALYRKKYARCPDPTVAVYKQDLYYGSVSERTRKLITDYAKRKPALKETIADIMRVKTIKSLAAPGEPVGLIAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIPIKPGQQHQAEKLRINLNSVTLANLLEYVHVSTGLTLDPERSYEYDMRFQFLPREVYKEDYGVRPKHIIKYMHQTFFKQLIRAILKVSNASRTTKIVVIDDKKDADKDDDNDLDNGDEVGRSKAKANDDDSSDDNDDDDATGVKLKQRKTDEKDYDDPDDVEELHDANDDDDEAEDEDDEEKGQDGNDNDGDDKAVERLLSNDMVKAYTYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGKSVVHQVQHIKRAIIYKGNDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVSNVFKVYGITVDRRHLSLIADYMTFDGTFQPLSRKGMEHSSSPLQQMSFESSLQFLKSAAGFGRADELSSPSSRLMVGLPVRNGTGAFELLTKIC
The following text describes a protein:
Function:
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Nucleus matrix. Note=Colocalized with PXN at focal adhesions during myogenic differentiation (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus.
Sequence:
MSSECDVGSSKAVVNGLASGNHGPDKDMDPTKICTGKGTVTLRASSSYRGTPSSSPVSPQESPKHESKSGLEPEDPSADEWKLSSSADTNGNAQPSPLAAKGYRSVHPSLSADKPQGSPLLNEVSSSHIETDSQDFPPTSRPSSAYPSTTIVNPTIVLLQHNRDPASERRAGEQDPVPTPAELTSPGRASERRAKDASRRVVRSAQDLSDVSTDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDVHSPRYSFSDDTKSPLSVPRSKSEMNYIEGEKVVKRSATLPLPARSSSLKSSPERNDWEPLDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGRPTNLEKDLSFCQAELEADLEKVETVNKSPSANSPQSSAVSPTPDITSEPPGYIYSSNFHAVKRESDGTPGGLASLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSVHSRTFHTSNALGPGCKHKKPLSAAKACISEILPSKFKPRLSAPSALLQEQKSVLLPSEKAQSCENLCVSLNDSKRGLPLRVGGSIENLLMRSRRDYDSKSSSTMSLQEYGTSSRRPCPLSRKAGLHFSMFYRDMHQINRAGLSLGSISSSSVRDLASHFERSSLTLARGELGASQEGSEHIPKHTVSSRITAFEQLIQRSRSMPSLDFSGRLSKSPTPVLSRSGLTSARSAESLLESTKLRPREMDGMDSGGVYASPTCSNMADHALSFRSLVPSEPLSICSDELDHCSNVSNDSREGSGGSVHGDFPKHRLNKCKGTCPASYTRFTTIRKHEQQSSRQSDWRSDSRGDKNSLLRNIHLMSPLPFRLKKPLQQHPRQPPPSDSSESPAGQKADLPCHDPQDQPHSAGKPQVPTRLSSRHTMARLSHNSEPPLDRPAGLEDCTRAINNGNPVPYSDHGLDRNNNPQSELAAAHGDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGLEMRPARAKFDFKAQTLKELPLQKGDVVYIYRQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPRKLAPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVLKRPLVKTPVDYIDLPYSSSPSRSATVSPQQPQAQQRRVTPDRSQPSLDLCSYQALYSYVPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL
The following text describes a protein:
Function:
Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MNKQDMADEALFLLLHNEVISCVYKAGGDQGDAENGKCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFVCKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLITQMSAGKQYLEHAPKYLAFSCGLIRGGLSNLGIKSIVTAEVSVMPACKFQVMIQKL
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Sequence:
MRITSSENFRKMDNYSIENIGIPSIVLMENAALKIVSNIDLQLNNRFVIVCGKGNNGGDGLAVARHLHCLNKEVEVFIIEKSKDGTKDFKINYNILKNMNLNIKTIRDYEDLDYLRESIMKSDMVLDAIFGIGLSRKIEGIHKDTISVINENSKSTLAIDVPSGLNANTGEIEGVCIEANTTVSFEMYKEGFLAYYRDKYLGNIIIENIGIPREALDLFSNDLYIIDKYMFKNNFKERNKYAHKGDFGKALFIAGSKGFSGAAYLCTEAAVKSGTGLVTLATSNDIQNILSSKLEEAMTISYEDYKDVKNIMVKSSCIAIGPGMGKNNNTEELLRKIIRDYNKTMVIDADGINVLENNLDIIKKARGEIVLTPHLGEFSRITGYDIDYIKENRLKLAKEFAKENKIILLLKGYNTIITNGKEVFVNSTGNSAMASGGMGDCLTGIITSFIAQGYDPLEATCLAAYLHGYCGEKLSSKMFCVNATHVLDYIPFAIKELQYT
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management; Protects stationary phase cells from killing induced by endoribonuclease MazF.
Subcellular Localization:
Cytoplasm.
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA (By similarity).
Sequence:
MSQNTLKVHDLNEDAEFDENGVEVFDEKALVEQEPSDNDLAEEELLSQGATQRVLDATQLYLGEIGYSPLLTAEEEVYFARRALRGDVASRRRMIESNLRLVVKIARRYGNRGLALLDLIEEGNLGLIRAVEKFDPERGFRFSTYATWWIRQTIERAIMNQTRTIRLPIHIVKELNVYLRTARELSHKLDHEPSAEEIAEQLDKPVDDVSRMLRLNERITSVDTPLGGDSEKALLDILADEKENGPEDTTQDDDMKQSIVKWLFELNAKQREVLARRFGLLGYEAATLEDVGREIGLTRERVRQIQVEGLRRLREILQTQGLNIEALFRE
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MSPPQPRCVNPKIWQRCAGAGVIIPKLHSKVYYFPKGHLEHACTSPNDHTINIINRYRPSIPCIISTVDLLADPYTDEVFAKLLLTPVTDGFIQESPRDTDQEDKGDDNVVSFVKILTKSDSNNAIGFSVPRACADLILPKLEFEVPMRSQKIFVTDVQGEVWNYNHTYHGKPKRHVLNNGWTLFVNKKKLVAGDSVVFMKNLAGKVFVGIRRHMKFAAAEAAAVPKEKLTEKTVIKAAELAEKSMAFEVVYYPSPNWNDFVVDAKVVDEAIKINWESGMGVKLSLKNEESLRMRYVQPQGTISNALSNVPNWRMLQVNWDGHENLQNQNHVNPWQVQLISKAPEMYLPFPTKRPRLAEGNNFLEDNSVERLTTVSKELNTGGPACDDLSAHNHSSLNTVGTKFVETHNCNTQIASSGSIMLFGKIIQPVEGNFHDHGTKLEATTTRTNSAQQGLVANK
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex); Plays role in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of toxin RelE; Induces its own promoter, in combination with RelE represses its own promoter. Binds DNA in complex with toxin RelE but not alone.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSNDEIRNRYTAR