The following text describes a protein:
Function:
Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Domain:
Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
Sequence:
MALDNRHRLIVGKLAEAFGLPENVIEKTLTQDKQAVNSFFTPAGPPSLVFVYQVKEDKLKDGSVGPVDNKPTLHRIGPHERIHNSVYFTRLNPKGINEKTLEADMGSGELSVLWALENFKAIVSDLYLPIMQEQQQWGKMSTEYLEDFLSSTAKFGSMLTEAVATVSGGVEPMPDPRYIDQYGDLRPAGITQAAGDDDTLQEMEECLTEWCREAELLLNQTNKIKDGEERGPDTELEYWRTRMSNFNSITEHLKTKECKLVLGICSHAKTKAYLRWRGLDVQITDAANESKDNVKYLATLEKSMEPMYQGRVTDITESLPALMTNVRMMYTIARFYSTAEHMTRLFTKITNQLVRRCKEQIMENGKIWDQDKVTLIGNMKVSVELANVYRQQYRLAKETLAAQPKSKQFDFDEQAIFLKFDLSSKALHKLIDMFTTIHQFSSLEQHTHIEGLDTMLKSLNNIIDDVKRKPYDLLDYSRNAFDTDFLEFNVQINDLELQLQGFVNASFEHITSTEHALSLLAQFQAIMQRETLQQDLENKYMVIFQNYAKDLDAVQKLYEKNKYEPPVPRNAPPVAGNIMWARQLLRRIEAPMQLAQNKNLLAAKESKKNIKTYNKVAKALIEFETLWHQAWIKSIEQCKAGLAAPLLVQHPDTGKILVNFDKEIMQLVREAKYMQRFNIRCSSPSQMVLLQEEKFKFYHNQLTHLVREYEHVLGRGATIKPLLRPHLDDMERKIAPGFAVLTWTSLNIDGYLHRFKQGLARLEELVRKVVDLTENRVDSNLGAISSTLLVELPTDRSFTYEGFVEQNRFQKKQAELLAIRNEEVRRAIEDLYTLVRNYPRENTEDVLDEKEVSLLVRHYSKNMYNAIMQCTLNSLQAMKRRLGSKTTTGIFFMERPFFDVDVELKVPSVCMNPTLEEIQAAINQCAKKVLTISKQLPAWGMDNVATYHEMMRGDRRWVKAVLRLTGSVEGIKTQVGEYIRTFDKYDFLWKEDLQAAYDHFMRSNPTLEAFEAELKKYMAIETEVTMINGVNNIGALSLETHPLKNSLKAEAVSWKTQFAQNLHKQCSDDLKLDNYIRDTNSKFHRKIEDLEDVRNVMAVLKEVREKESEIDNLIGPIEEMYGLLMRYEVRVPKEETTMVSDLRYGWKKLKKVATEVSDNLTRLQVGFKRELIKEVKTFVVDAQMFRKDWEANAMVPGLDPQEAVDRLRKFQQMFEVRKRKWENYSSGEELFGLPVTQYPELEQTEKEIQMLDRLYSLYVAVITTIKGYGDYFWVDVVEKIDEMGEQVQQYQNQSKKLPKLRDWPAYNACRKTIDDFLEMLPLFQALTHKSMRERHWKEVMRVTGHELNLAEDHFKLQHLLDCNVLRYREDIEDLTGAAVKEEIIEVKLNQLKADWATANLALAEYKNRGPVILKPSDTSELMEKLEESQMTLGSMATNRYSAPFRDEVQAWSIKLSTVSEIIEQWLMVQSMWQYMEAVFSGGDIVKQLPQEAKRFLNIDKNFMKIVSNALETQNVINTCFGNELMKNMLPHLHEQLEMCQKSLSAYLEQKRAEFPRFTCVGPHLLEICRWAHDPPSVVPHFQSGLFDSLSNVTFDRIDKTRMTEMFSQQNEKVEFERPVDAKGNIEVWLQRLVDGMEDTVKQIIKRAVRNVAEMPLEDFVFGHPAQVSLLGIQFQWTAETQMALSSAKVDKTIMNKNMKKVDALLRDMVNITVRLDLTKNQRTNLETCITVHMHQKESTEDLVKKKIKDPTDFEWLKQVRFYWRDDKDTVIISICDVDFEYSFEYLGVKERLVITPLTDICYITLSQALGMFLGGAPAGPAGTGKTETTKDLGNTLGKYVVVFNCSDQFDYTYMGKIYKGLAQSGLWGCFDEFNRINLDVLSVCAQQVYCICRTRERKKSFQFTDGTTVSLDPRVGFFITMNPGYAGAQELPENLKALFRGVTMMVPNRQIIMKVKLAAAGYQENDILSKKFFVLYGLCEQQLSKQAHYDFGLRNILSVLRTAGASKRQSPDKSEVFLMMRTVRDMNMSKFVAEDVPLFLSLIDDLFPGLKADATRPDVNKDAEKVVLERGLQVHPTWMNKCIQLYETYLVRHGIMLVGPSGSGKSAICECLAAALTELGTKHVIWRMNPKAITAPQMFGRRDDTTGDWTDGIFAVLWRRAAKNKNQNTWIVLDGPVDAIWIENLNTVLDDNKVLTLANGDRILMSAAMKAMFEPENLNNASPATVSRAGIIYVSDVELGWEPPVKSWLQKRDPTEACWARLFSKYIDRMLEFVRISLKPVMYNEQVSIVGTVMTLLNGYLKSMKEAGTAMNDAKYERVFLYCMTWSLGGLLEMKERPLFDQELRTFAHNMPPKEEDSDTIFEFLVNTTDAEWLHWRHCVPVWTYPKNEEKPQYAQLVIPTLDSVRYGALLNLSYNVDKATLLVGGPGTAKTNTINQFISKFNAETTANKTITFSSLTTPGIFQMSIEGAVEKRQGRTFGPPGGKQMCIFVDDISMPYINEWGHQVTNEIVRQLLEQGGMYSLEKPIGDMKFITDVRYVAAMNTPGGGKNDIPNRLKRQFAIFNVPLPSVAAINGIFGKLVEGRFSRDVFCEEVVYVASKLVPLTITLWNRIQTKMLPTPAKFHYLFNMRELSKVFQGVILATRDRFNLAAGDSAVFGGNVASPEGYLLGLWIHECRRVFSDKLISYEDKNWVDKAVFDLCRDNFSSDLVKQVEEPIYFVDFLREPAVMMRPVEIVTPHPSFYYSVPGGLPEVRARVEGLQRKFNEESKVMKLELVLFTDCVTHLMRITRLLAWPGLGLLVGVGGSGKQSLSRLSAYIAGPTFYITKTYNVSNLFEHIKGLYKIAGFKGQPVYFIFTDAEVKDEGFLEYINQILMTGEVAGLLTKEDQDMIVNDIRPVMKHQAPGILDTYDNLYNFFLNRVRDNLHVVLCFSPVGAKFARRAQQFPGLINGCTIDWFCPGPKKRLTSVSGKFIDKFTMACPKEVKNQLELLMGHAHVFVTAACKEYFEKYRRYVYVTPKSYLSFLQGYKELYAKKWSFTKELAYQIEVACQKMFEPKADVNKMKAELAVKNQTAVSAKEAEALLKQISESTAIAEKEKQKVAVIVDAVTKKASEIATVKDDAERDLAAAKPALDAALEALNSIKDGDIKNLKALKKPPQIITRIFDCVLVLRMLPVTKAEYTDEKGRMVQVGNYPEAQKMMNQMSFLQDLKDFAKEQINDETVELLEPYFMSEDFTFENAQKGSGNVAGLCNWAESMAKYHNVAKVVEPKIAKLREAEAELKLATKEKNAAEERMAKVQAKLDEMQAQFDAAMAHKQALEDDAAATQRKMDSANALIGALAGEEARWTAQSKEFDVQIQRLTGDCALASAFVSYLGPFNKEFRELLLNRDFYGDCMKLNVPVTPHLQITKFLVDDSEVGEWNLQGLPTDELSIQNGIMVTRASRYPVLVDPQGQGREWIKNREEANQLKTTQLNDKLFRNHLEECLAFGRPLLIENIEEELDPLLDPVLERRLVKKGKTWVVPLADKEVDFTETFRLFCTTRLPNPHFTPELSAKVTVVDFTVTMAGLEDQLLGKLISKEKKELEDQRQQLLEEVQSYKKRIKQLEDDLLCRLSNSQGNLLDEHQELIDVLAVTKQTAQDVSEKLANASETNKRINEACEEYRPVAHRATLLYFLIAEFSVVNCMYQTSLAQFNQLYELAIDRSEKANMPSKRIHNIIEYMTYEIYLYVQRGLFERHKIIFALMLTNKVLTSAGKVKATDLDVFLKGGAALDINSVRKKPKDWIPDLVWLNIIALSAMDAFRDIPDSVFRNDGLWRQWYDQEAPEMAKVPDYEDRLNKFERMCVVKTFREDRTLIAAADYIAEALGQRFVESVPLNMEKRPGRRAMAKCPLICLLSPGPDPTKLIEDLAKKKKIKTLGVSMGQGQEVIARKHMAAASLEGHWVLLQNTHLGLGYLTEVETFLVKEENVHEDFRLWITAEPHPQFPIGLLQMGIKITNEAPVGIKAGLRASYQWVNQDMLDMVSRQEWRQLLFVMCFLHSVVQEPQFGPIGWNVPYEFNQSDLSACVQFLQNHLSEMDAKKAPQPTWETVRYMISAIQYGSRITDDFDKLLMDTFAEKYFLQPVLQPSYELFKDTRSSDGFSYRVPDSTDIETFGSYIETLPGTESPEIFGLHPNADITFRTLQVQESIVTILDTMPKGAGSGSGLSREDVVDKICEDLLSKAPPLFDKEETKEKLKKLPGGPTLPLTVHLRQEIDRLNIVTRLTTTTLKNLALAIAGTIAAERGLIDALDALFNARIPQQWLSKSWEASTLGNWFTGLLQRYDQLNKWLNLGRPKAYWMTGFFNPQGFLTAMKQEVNRKHRDKWALDDVVMSSEVTHRPKDFESLKEGAPEGVYVYGLYLDLRLDGRENRLMDSDPKKLFNPLPVLHVDGVLAKDKKRSGLYEAPKPYRVKARKGLNFITTFSVRTEDDKSKWILPGVGILCSID