lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos.
Subcellular Localization:
Endosome.
Sequence:
MAERQSASSPTPSSPPQQQQQTPQQPPQYLLNSKKNFKVKVLNGREVERHPLNSITKTEDTGKPKQSSLSSNASSLQSAAAAASSSTATTDIDPLNNNNNNNTDIDPLNNPLEKKHDPLSETIATMGGLKLIKENHLTNYVDENFMPWDTLKPSILQQYTSDDSNPIQVSFMSTGTSGKIKIPINRLNKILEELEQDKEDSKSTQFSQPDIIMDLETLHSELLKAWAAEERVRSLKIAIQTAKLLSDTSLIKFYPSKFVIATEILDTFGNLVYDRIKKRLQSSKESKNHEILLKEQAKETCRNWFYKIASIRELLPRLFVEISILKCYEFIQGDVNTEPKQVINRISEMIRGIGNPLVANYIRAYLTRRSFDLCPEYKKFVIQLLKDFVFTQKSYEKSKYLENTLSMYRITLTDYMGLYSPSLEWLLQCLAHKATPETLEEVLELFRESKNSLLLNHIISSFPPEYICSNSTMFSNFIKDADTLSYPKYQLYSTFGVNLVLGQPPKNQILSILNDVWKVVTNFENIKDYISVAEVFIEYVLTHCSEKETDVFLKDILRHIIPDKGYETIQSHLQSIVLKIFTHISDFGKLVSFTNFLPLLDLFNGESQKQISRSTLEALSTSKVMTSDPILINTFLTYGKALHDSLNSLSFQDEVRQVTQLVVNCINKIDFGRDVEKQLNFYVECRQTFINFDGVKNRLVYGVCEICEKTLNLVKGKHTPKTTSFIRACVAYCFITIPSIDDIFLKMNLYLVSSSVALQNQALSQADALLKAAITFIQEIPPILEFKQVKSTEDWTISYVSDFISLLVVTPGHPESGPFYLVKALYKVIKEYQWESSSTAKSKLFIQLLLLCSSWAQTSLPYHIEKVESNDQLFTEDPEFNTELTEFYNSLIKEILYDLNLLKDEPDNLTQKKVGIICIDLINALLNVGELNSKTASLIFNLYNMAKKIIPSTCFNEITYLKNTLAFIGTLESKMGQDIFNKLSQQQ
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Bud32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit osgep (By similarity).
Miscellaneous:
MISCELLANEOUS: This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event. Bud32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit osgep switches the activity of bud32 from kinase into ATPase (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDANECSNSENSATTTIPKSASPSTTISTKVVKLDEIGILISQGAEAKTYETDLYGLKCIVKERFSKAYRHPILDQKISSKRILQEVRSLNKCKKKGIQVPSLYLVDIGNNRIYMEFIKGETVKHYLYKNQESTQHQNQIESIMKELGNQIGIIHEMNVIHGDLTTSNMLLRESTNELVFIDFGLSYTSNSVEDKAVDLYVLERAFISTHPNSEQLFQTILSNYELTSSNSKIVIQKLNQVRLRGRKKTCFG
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRIGYRGFSTRSRVFKLSPQEYVNQVQQEKIENEQFKQALSQDQLEYNPKILSSHKLTKNRPIPINVELLKYKPLRLPKTHGDEVATLTIRGYDEDNLIRVGEFALRTAYYMGIPMSPLMALKTEKRLYTVIKSPFAQAKTKQNFHRVTYKKKLVAYDANPEIIDLWLSYINKNKFTDVEYKATVSSYESLNYHEELKSLKEFNLPDAYEGIEDPVAKKVQELLKSKSFKKHL
The following text describes a protein:
Function:
Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.
Subcellular Localization:
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MATLTAKNLAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDDDISLLPLHARARRGIGYLPQEASIFRRLSVYDNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILLDEPFAGVDPISVIDIKRIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQDEHVKRVYLGEDFRL
The following text describes a protein:
Function:
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MGVCSAPHCSNSSYIGKQLFRFPKDPERKKKWVVNCQRDFEPTPHSRLCQDHFEQSQFEEIAKSSAGRKKLKPNAIPTLFCVRNPPYPAVTTPYIRLTPLKDEPVRVMKKRLYRLSRIEMGLQSFLYEDQIRALSLPKRSRRAVWSPETILEARNIRSIVGTKGYDYLREIGYPLPSYRTLCNRVETKLMVTTDINCEDLDELHLGFMASCESPIERVGDHDEEELIGVLS
The following text describes a protein:
Function:
Catalyzes the desaturation of medium-chain acyl-CoAs to 2-trans-enoyl-CoAs. Active on C8:0- to C14:0-CoA with a maximal activity on C12:0-CoA.
Subcellular Localization:
Peroxisome.
Sequence:
MSDNRALRRAHVLANHILQSNPPSSNPSLSRELCLQYSPPELNESYGFDVKEMRKLLDGHNVVDRDWIYGLMMQSNLFNRKERGGKIFVSPDYNQTMEQQREITMKRIWYLLENGVFKGWLTETGPEAELRKLALLEVCGIYDHSVSIKVGVHFFLWGNAVKFFGTKRHHEKWLKNTEDYVVKGCFAMTELGHGSNVRGIETVTTYDPKTEEFVINTPCESAQKYWIGGAANHATHTIVFSQLHINGTNQGVHAFIAQIRDQDGSICPNIRIADCGHKIGLNGVDNGRIWFDNLRIPRENLLNAVADVSSDGKYVSSIKDPDQRFGAFMAPLTSGRVTIASSAIYSAKVGLSIAIRYSLSRRAFSVTANGPEVLLLDYPSHQRRLLPLLAKTYAMSFAANELKMIYVKRTPETNKAIHVVSSGFKAVLTWHNMHTLQECREAVGGQGVKTENLVGQLKGEFDVQTTFEGDNNVLMQQVSKALFAEYVSCKKRNKPFKGLGLEHMNSPRPVLPTQLTSSTLRCSQFQTNVFCLRERDLLEQFTSEVAQLQGRGESREFSFLLSHQLAEDLGKAFTEKAILQTILDAEAKLPTGSVKDVLGLVRSMYALISLEEDPSLLRYGYLSQDNVGDVRREVSKLCGELRPHALALVTSFGIPDSFLSPIAFNWVEANAWSSV
The following text describes a protein:
Function:
Has a role in inhibiting host-seeking behavior during a reproductive cycle.
Subcellular Localization:
Secreted.
Sequence:
MWKFASIVVLVVCLAWAVYCEDQRPPSLKTRFGRSADEPESDNYVSNDIMEKRSAQRPPSLKTRFGRSEGAEVMEKRSAQRPPSLKTRFGRSVANPESDGYMRKRSAESEPFVTRIRHGRANKKRAAN
The following text describes a protein:
Function:
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Photoreceptor inner segment. Apical cell membrane. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells.
Sequence:
MWWFQQGLSFLPSALVIWTAAAFIFSYITAITLHHVDPVLPYISDTGTVAPEKCLFGAMLNIAAVLCVATIYVRYKQVHALNPEENRIIRLNKAGLVLGLLSCLGLSLVANFQKTTFFAVHVCGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSLLYNGSFGADIVQKLHWNPEDKGYVLHMITTAAEWSMSLSFFGFFLTYIRDFQKISLRVEATLHGLTLYDTAPCPVNNERTWLLSRDV
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HicA-mediated cessation of cell growth and inhibition of cell proliferation.
Sequence:
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
The following text describes a protein:
Function:
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Subcellular Localization:
Cytoplasm.
Domain:
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Sequence:
MGMYNKIDSNKSFVQREKGIADLWKDRGVIEKSFNLNEDGEYFTFYDGPPTANGKPHVGHILTRVMKDLIPRYKVMKGYKVLRKAGWDTHGLPVELEIEKKLGISGKPQIEEYGIEKFVTECKDSVFKYTSLWKQMSEQLGFWVDMDDPYITYDNNYIESVWWALKQMWKKELLYKGHRVTPYCPRCGTALSSHEVAQGYKDVKEATAFVKFKIKGKENKYFLAWTTTPWTLPSNVTLAINKSYDYVEILNNDEHYILAKELLGKVIEGEYEVVKEFKGEEIVGVEYEQLFKFEVPEKKAFYVVHADYVTLTDGTGIVHTAPAYGDDDSKTGKKYDLPLINLVDSEGKFVDSVEPWKGMFVKKADPKILEYLKENGMLYKSEKFTHSYPHCWRCNTPLLYYPKDSWFVRMTSLRDDLVKNNNTINWYPDNIRTGRFGKFVENVIDWGISRDRYWGTPLPIWECDCGHRECIGSVEELKEKGINVPENIELHKPYIDAVKLNCPHCGKEMTRTNEVIDCWFDSGSMPFAQHHYPFENKEVFENTFPAQFISEAVDQTRGWFYTLLAISTALFGKSSYENCIVLGHVLDKHGLKMSKSKGNVVDPFDVLENEGADATRWHFYTASAPWLPTRFSEEDVKETQRKFLSTLWNVYSFYILYADLDNFNPLEYKEFKSEHVMDKWILSKLNSLIKNVEEHLDNYRITQAALELEEFVDELSNWYVRRNRSRFWSTELTDDKIGAYTTLYTVLTTVIKVAAPFVPFVTEEMYQNLVVNLDKDAEESIHLCKWPSYNESTMDKDLEEKMGLAYKIVKLGRSARNSVNIKNRQPLKKMLVSTKELPEYYEDIIREELNIKEILSGADLSDYVNFEIKPNLPILGKKYGKFIPAIRKEISSMNQMELAQSINNSRSVFINVEGCEDQIELTAENLLVTMQGLEGFAFAGEGEIGVVLDTHITEELKEEGFLREILSKVQNMRKESGFEVADKINLYVSGNNTLNAIVKKYEDEIKVETLSVKVMYDENKDYIECKINGENYNIAMEVVK
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
SQVEAIILLLHYQWSPSKIEDEWFTDEEKVRESAGLLKEPVVDLNDKVNIECGICFDSFLQKDSATVSCGHPYCKTCWTGYITSKINDGPGCLTVQCPEPSCSAVVGQDMINSVITKEEDKEKYYKYFLKSYIESSQKKIKWCPSPGCEYAVDFGGESEKYDVSCLCSYEFCWKCCEDAHRPVDCHTVAKWIFKNNDESENTTWILANTKPCPSCKRQIEKNQGCNHMRCSICKHSFCWACLDPLNNHKSCHNFRGETEVKREMAKKAIDRYMHYYERWVGNQSSRVMAMADLKKLQSVQLVKLSVKHGIRETQLQFTVEAWLQIIECRRVLKWTYAYGYYLPEQESTKKRFFEYLQGEAEVGLERLHHCAELEFKELVNETEYFSKKFEDFRRKLIGLTKVTKTYFENLVKALENGLADVEPNETKSATDSNKRQKLV
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MGSTVNYLSYWQYAETTASGHPVLREGERDIYVEQDVGLYHGKIKILNKQKGRCYLTSQRIIYVDDTFHAKESVSIELDDVEKARYNAKFLKRATKTVLFLKPNSKHSLGGKASRSNVDQKTFKRIVEKSQWTCAICMAHNEVNMEIQGYMPPCVNCGISVDFEMISKSLTIVYADDATDAAKNKCPACTFDNHVHMNNCEMCGTRLPNMCPTALTRNQQLGGDPRVHIELEGNPGFTSRDIPFVQLSFRRSDGSLFFEALCKQLEDWESDQKKHMFNQDLTKVNGVGLETPIFEQDTRFSTLGIASLEKSREEQLLKNDILLNKALTDLGNLAALASDIEKLYHDGESAPSNTNPTLVIDRDKFLSKSAFIDEIAREIYQLTVSEFKDQREKHGTILVPLVDLYALYNKSMRIGTGYVSPEEMREACERFGKLGLTDLSLSRINGRVLCIASANSFEAVKRKIMSTIEHSPGADLLQITKQLNRENDNAWAIGIIMEVLQNCVKEGNLLIDEQISGIHYYINVCWRI
The following text describes a protein:
Function:
Cell cycle regulatory kinase that is not rate-limiting for cycle progression under normal growth conditions. Transcriptionally activated upon DNA stress or damage in an ATR- or ATM-dependent manner. Once activated, inhibits plant growth by arresting dividing cells in the G2 phase before proceeding into mitosis. Down-regulates CDKA-1 and CDKD-2 by tyrosine phosphorylation. May target principally CDKA-1.
Subcellular Localization:
Nucleus.
Sequence:
MFEKNGRTLLAKRKTQGTIKTRASKKIRKMEGTLERHSLLQFGQLSKISFENRPSSNVASSAFQGLLDSDSSELRNQLGSADSDANCGEKDFILSQDFFCTPDYITPDNQNLMSGLDISKDHSPCPRSPVKLNTVKSKRCRQESFTGNHSNSTWSSKHRVDEQENDDIDTDEVMGDKLQANQTERTGYVSQAAVALRCRAMPPPCLKNPYVLNQSETATDPFGHQRSKCASFLPVSTSGDGLSRYLTDFHEIRQIGAGHFSRVFKVLKRMDGCLYAVKHSTRKLYLDSERRKAMMEVQALAALGFHENIVGYYSSWFENEQLYIQLELCDHSLSALPKKSSLKVSEREILVIMHQIAKALHFVHEKGIAHLDVKPDNIYIKNGVCKLGDFGCATRLDKSLPVEEGDARYMPQEILNEDYEHLDKVDIFSLGVTVYELIKGSPLTESRNQSLNIKEGKLPLLPGHSLQLQQLLKTMMDRDPKRRPSARELLDHPMFDRIRG
The following text describes a protein:
Function:
Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.
Subcellular Localization:
Lysosome.
Sequence:
MGAGARPSGVRAGGGRGAAGPWMSSRALRPPLLPLSLLVLSLQAAPGARAAGYETCPKVQPDMLNVHLLAHTHDDVGWLKTVDQYFYGIQNDIQHAGVQYILDSVISSLLEEPTRRFIYVEIAFFSRWWHQQTNRTQEIVRDLVRQGRLEFANGGWVMNDEAATHYGAIIDQMTLGLRFLEDTFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKKVRMEKLEMEQVWRASASLKPPAADLFTSVLPNMYNPPEYLCWDTLCADKPVVDDPRSPEYNAQKLVDYFLQVATAQGGHYRANHTVMTMGSDFQYENANMWFKNLDKLIKLVNAQQQANGSRVNVLYSTPACYLWELNKANLSWSVKQDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALAGPAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVADDYARQLAAGWGPCEVLLSNALARLSGSKEDFEFCRDLNISVCPLSQTAESFQVTIYNPLGRKVDWMVRLPVSKHVFLVRDPSGTVVPSNVVTLPDSDSQELLFSASVPALGFSIYSVSGQSVRRPQAHTLRVRIQKPASRVLAIQNEYLRARFDPYTGLLVELENLDEKLLLPVRQGFYWYNASEGDNLSTQVSGAYIFRPSRQEPLPVGRWAQTHLVKTALVQEVHQNFSAWCSQVVRLYPGRRHLELEWTVGPIPVGDDWGKEIISRFDTALKTNGLFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNSRIYITDGNVQLTVLTDRSQGGSSLSDGSLELMVHRRLLKDDARGVGEPLLENGLGVWVRGRHLVLLDKARTAAAGHRLQAEKELLAPQVVLARGGGAPYHLGVAPRTQFSGLRRELPPVVHLLTLARWGPTTLLLRFEHQFAVGEDPGGNLSSPVTLDLRDLFSAFTITHLQETTLAANQLSARASRLQWTPNTGPRPGPTPHLSPSRLDSSTIELQPMEIRTFLAEVQWEEDS
The following text describes a protein:
Function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr); unlike most archaea the editing function is found in a freestanding protein (ACQ980D1). In vitro when both subunits are present, or if the 2 subunits are fused, L-seryl-tRNA(Thr) is no longer produced, the 2 subunits edit incorrectly charged L-seryl-tRNA(Thr). Has no activity on correctly acylated L-seryl-tRNA(Ser) or L-threonyl-tRNA(Thr).
Subcellular Localization:
Cytoplasm.
Sequence:
MESYKPVWLKGAVILAINLIDKGYKPVAVGLGERDFYIDVKSDTSITLDEVKKAINENVLANVSIENNQIVYKGNKVSIIEDKVSISTNLNPKYFEILNISTHHPNPNEQYVRIRGVAFETEEQLKDYLSWLEKAEETDHRLIGEKLDLFSFHEEAGSGLVLFHPKGQTIRNELIAFMREINDSMGYQEVYTSHVFKTDIWKISGHYTLYRDKLIVFNMEGDEYGVKPMNCPAHILIYKSKPRTYRDLPIRFSEFGHVYRWEKKGELYGLLRVRGFVQDDGHIFLREDQLREEIKMLISKTVEVWHKFGFKDDDIKPYLSTRPDESIGSDELWEKATNALISALQESGLKFGIKEKEGAFYGPKIDFEIRDSLGRWWQLSTIQVDFNLPERFKLEYIDKDGIKKRPVMVHRAIYGSIDRFVAILLEHFKGKLPTWLSSVQVRVLPITDEVNEYAEKVLNDMRKRRIRAEIDYAGETLSKRIKNAYDQGVPYILIVGKKEASEGTVTVRARGNIEVRNVKFEKFLELLITEIAQRDVEQTTVKALK
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MFKSFDGLKLSNSELEGRYIIANRDIDIGESILKCKSYFAVTCEDFKKNSCYNCIKLIKSPSPQQVPRCFGCNEVWYCSEKCKQDNQAKHQHYECAFFNNIKSPKLIQNSKLDFDSYSEIRIILGLLSRYYQDKLLNNKFNSSIIINNQQDDEEDFIKDTLDGVLDLVENDINEETNSVAKEYIDNIIEYIINILKLTINNNSNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIEELIKLIRPLIQKVRCNQFGIWTKNDKCIGMAVSPSSSYFNHSCIPNCESVRDGSDMTFKSLFPIKKGDQINISYLALDKSTKRRRDYLKFGYYFHCQCPRCNSTDIDPTGKLEDSLDNWISKFYCHQKKCTGLYYSKLKLSLQSLTNIDNHEIQLSCSTCNDQLIVNSNFYLNKPNY
The following text describes a protein:
Function:
Transcription regulator that can specifically activate or repress expression of target genes. Activates expression of genes such as molecular chaperones (groL, groS, dnaK, grpE, and cbpA), proteins involved in acid resistance (hdeA, hdeB, and gadA), the starvation lipoprotein slp, virulence protein hlyE/clyA. Represses expression of genes involved in the histidine biosynthetic pathway such as hisA, hisB, hisD, hisF and hisG. Required for the activation of virulence genes.
Sequence:
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLITLIAKLEHNIIELQAKG
The following text describes a protein:
Function:
Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. MetR is also a negative regulator of its own expression. Binds homocysteine as an inducer.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEVKHLKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEILLQLANQVLPQISQALQACNEPQQTRLRIAIECHSCIQWLTPALENFHKNWPQVEMDFKSGVTFDPQPALQQGELDLVMTSDILPRSGLHYSPMFDYEVRLVLAPDHPLAAKTRITPEDLASETLLIYPVQRSRLDVWRHFLQPAGVSPSLKSVDNTLLLIQMVAARMGIAALPHWVVESFERQGLVVTKTLGEGLWSRLYAAVRDGEQRQPVTEAFIRSARNHACDHLPFVKSAERPTYDAPTVRPGSPARL
The following text describes a protein:
Function:
Involved in the degradation of beta-alanine.
Sequence:
MSGRPQAVPTVQVDNAEVIVTEWRFAPGAETGRHRHGHDYVVVPLTDGTLLLETPEGDRHAPLVAGQAYFRKAGVEHNVINASAHEVVFVETEIK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MQMRAQMSAAAQQQASQPFQLSGATNTETMRNVVGAFMSAGRQHEQPAPARRPHKSEARMKKSHREEVWEDEEGGQFGEIDSAMRQVKKDWPFVMESDFSSSSLALSLLSQAPSPSLPQHPGLSSFLRLHDSLSAGLQAAVQANSKSFAASLPAHQNFLDILERAQEQVRKSKQELKAARDGFAGKGKSELSGIRARERTVRDMLRILDTIDNLRQVPDQLESLVGDKRFLQASLILVRSLETINKPELREIGALSDLRSYFMSQETTITEILIEELHNHIYLKTFYSDSRWRPYTPGRADLPIIGSQDEDLAFLRSPDPNSTSPNLSGNNTSSTTTNGNANATAGPGTSSKFSRYLSQLSTKPSTRPMLQYDGDPIPSTYTLPAVHSHQQPNALGLGSGTGIVQPGGSHTSLSSLLGTAGNTGNPETDSYVYIENLLEALAVLGRLGQALDTVAQRAPGEIFALVDGTLDEVEERTERHREEDLSVRPQNLLGNVDPTPSSRTNPPTATTTAVPSRKSLFSSAETSRIEISLGAAGPPQHAALLKDLFWTLYSKLAAVLEGHRVMYEVSRWISSRPDFKDSTTPKGSSINIPVLEMWRPVQQEVRTLLSNYLTDDRPGSRLDRNPILSINEVLRDPKVSRDKSKSMFRFNDSDSRAIQKEIKPIDDSVQQALRSSVPGLVNMQSDQPVSIAPDTDDRFSPSSSRYRTLVPPNAFNVTTLFHPTLAFIHRASAIVPPGFESETQGFSTILEDFVVKVFLRQLDEKVTAGFQKAVSGYDAYQVDRGVLADTKQRPLKSSVRVMALIHSLCIMLQTTPFHRENYSRLIVGVIVQYYQQCSARFKDLVSHPATFETDSERPMVIPAVWAQREDITKCLSEMRSVPTTDRAGMASVSHKEIRLEMELLRDRPVSESNLINSSRKLEALGNLSQSLRWFIAALLDLQWVSEEPVSPEGEQPELDVLKTAPPLSADSDEPRLPLTRAMAQRYQAIIQTYEQLAEMVVNAIRLEIRCKVMCNIGASMQKGDFRLESEALEPDSDILDLNASLVEFEELAQRTISPDDHSFIFRALGQLVDHCLIAYASKYVKGVNAAGVRKIKRNILSLQQTLRGIATANEQGVLVRATEFWDLYEQGPKKMLEDLKNINGTPPYAFEDYNTMLKLQCKSNTDELNTYLIDLHALSMDVEGWDLGED
The following text describes a protein:
Function:
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSGDSAFNIDTWLQQEVAEIGVPDASHASLAAHLHAKDNLATLRDKFEYPKNATLPDVDLSIVNPQDDSIYLCGNSLGLMPKATRRIMNEQLDKWGQMGVFGHLTQPIPWAHGDECAIEGVAALVGANPVEVALMNGLTVNIHILLTAFYTPTPTRHKILLESRAFPSDHYAIESQLRLKGLDPATSMLCMSPRDGEETLRTEDILKTIEEQGDSIAVVFFSGIQYFTGQLFDIEKITRAGQAKGCFVGWDLAHAFANVPLKLHEWNVDFACWCSYKVSCMVARVPEVSRGLSFMKVLDLDEGAAGYRISNPPVHLVVPVMGFLETIDNVNLEDLRKRSYRLTGYLEYLIEYVQGKECPRSASCLPIYGKMVMVQNGFNVSIDYIYKELVMRGVAVDKRYPYIIRVAPVHLYNSFIDIRRFVDVLIESVSIVEEKL
The following text describes a protein:
Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Membrane.
Sequence:
MAKEDEKKESGSWKDFFWNPRTHELLGRTASSWGLILLFYLVFYTFLAGVFCLTMYVMLLTLDDYQPTWQDRLATPGMMIRPKGEALEIVYSRENTESWELYVQALDSFLKPYNNSQQAVNNDDCTPDQFNIQEDSGNVRNNPKRSCRFNRTTLEDCSGLTDRFYGYPDGKPCILIKLNRVIGMKPGKDGQSPYVTCGAKRYKEGDEWKEDAESIGEIAYFPPNGTFNLMYYPYYGMKAQVNYSQPLVAVKFMNISFNTDVNVECKINSNTITEFSERDKFAGRVSFKLRVNN
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MTSSEGELEEQLKETGNKLLNPPSSIDELLNLLDKVESLLANVEQAPSESMKDALLPSMKALIANELLTHSEMDVKVSVASCLTEITRITAPDAPYNDDQMKEIFHLTVAAFEQLPYMSSRCYTKAVSILETVAKVRSCLVMLDLECDSLVVEMFQNFLKGLRSNQPHTVFSAMETIMTLVIDESEEISSDLLVPLLASVKKENETASPIEWELGERIITNCAVKLEHCLKEAVQSMGIALDEYSQTVASICQSGSVPLEHEHVNGYGEHSADDKLEESTDSDLPPKTDPNEPPQVTEGLAPDTVCGTKVGQLVDGTLKSAMSNGIRNDETLKNEKTSKSLQSRVLAKHSKSIGARSNAEPGSLGSTKAAKSEIERVSVPKKRGRKPNSLMNPEEGYDHTWISPGRKTTITHRRKSHDGGVDDTPSENPDSSMANLSLENVTEPSAFEAKTNEIVVPAAPSPEHGLPDSSLRKRGRPKKKGNTANQDADPDSHSRSKGRFLKAHVGEKALQSADLSMKKESEVLSNCNTKAQGRSRKIRIATTPKEETTVAPGYVVSEKEADVPCVPEEKHPCPSTMNVDGMNDKSLIQLVIKKRKRGDVPSKQDISETSGSKMISKSATKSTNRDDSYLEETSKSKLKRMRTTGKKEVQSSEKSDLDEQLVGSRIKVWWPLDKMFYEGVVNSYDPVKKKHQVLYADGDEEVLNLKKECWELVGDNVLPVGQETNAQEPCASSDLLQKRRGKAKSKSAKREIVDSSSKRSGALGGRSEVVERTESGGNSADNLEPDKPIVGSESVNDPSMAEDGLKDDHIKSTGKLRIERLKTGTNLMQNVPKATTLPKGFL
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
G domain binds GTP and has GTPase activity; Arf-GAP domain interacts with G domain and may regulate its GTPase activity; PH domain binds phospholipids and is required for nuclear targeting.
Sequence:
MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAVGAPGARGSEPRDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGAGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPFKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSTAGTGASAVAAGGGGSAAVTTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPSAGSPPLTVPAIPVPATSVTAASTQPLGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGPGPLPGPQGLSSSSGSRELLGAELRASPKAVVNSQEWTLSRSIPELRLGVLGDVRSGKSSLIHRFLTGSYQVLEKPESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSHLHGQLISLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCTDMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGPEASTPMPSPSPSPSSLQLPTDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLSTPSKTEGSAVQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSTCVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPTRDSSREERESWIRAKYEQLLFLAPLGTTEEPLGRQLWAAVEAQDVAAVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSTATTPSAATTPSITATPSPRRRSSAASLGRVDTTIALV
The following text describes a protein:
Function:
Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine (By similarity). Transports with a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Plays a physiological role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MALDFLAGCAGGVAGVIVGHPFDIVKVRLQVQSTEKPQYRGTLHCFQSIIKQESVLGLYKGLGSPLMGLTFINALVFGVQGNTLRALGQDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQAVGPARTYKGSLDCLVQIYRHEGLRGINRGMVSTLLRETPSFGVYFLTYDVMTRAMGCEPGDRLLVPKLLLAGGTSGITSWLSTYPMDVVKSRLQADGLQGTPRYRGIVDCMRQSYQAEGWQVFTRGLASTLLRAFPVNAATFATVTVVLTYTRGEEAQVDSEAALGTSPTPAGSALAQPSSL
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAKLSPLTLIFIAACLSRILQLTILSGLSKALPLFDTSPSLLLSSPPPALRWDAIHFASVAYNGYEYEQQVAFQPGWLAVMRLAGEGVRFIRAASVVELKDVILGGTIVANVAFVAATLVLYKLTKHIFNPTFAFLTSLLYLLPPTATPSAPYTEPIYSLLTFSGIYLLSIKRQMVLAGLCFAGATTIRSTGIFNSITLMCFAVFGDAHIFDLDPKDYCKIRKKLKPFLSAILVVAPFFMFQHYTETVFCTRELKRASTARPWCSNSPPVSYGFVQKLYWNVGPFEYWTVSQLPNFALAMPILFFSLAGVVKFFSHLVSSSQVLNHGTEEIPPPPILFELYSVHVLTMALLLFTSHTQITLRVCLGDPVVWWNAVKLGFDNVQIGEAPTGQVKVNKFGRYWIGWTVVWGAVAAVLWAGHYPPA