lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYLLQRKASPPTV
The following text describes a protein:
Function:
Vesicle trafficking protein that functions in the secretory pathway.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Prevacuolar compartment membrane; Single-pass type IV membrane protein.
Sequence:
MADAWAREFHETALLTEEIDGRIAEKNALPAHSSESIRVVSVSRRKLAVLNNKLDRLESLLQSDSLKSSLNEKELNRRQNMLVDIRFKFKQMSESLSSTRDNRASLMEGGIAPVETSRTQDLDNTGLVKLQRQIMKEQDQDLESLEKTVLSTHHIALAVNEELDLHTRLLDDMDQDADVTNNKILAAQKRLGYLNKNLGQEWSLLTMIILMVVVVVLVLVLFKLL
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MSVVDEAALAAVRAHMKSVRIPGFHDKVYKDECMFSYDDPESPGGLYVNLATLQGFGESFLPLDHSRTGGGLYLHLVHRRVPLPKAEVEAARQAAQAAGQLLLNAPTYRLDKAMALVVVNGPGPEQRLRVPLPCPDLPERVLQAIDAVVKHESVTQAEALAVFEEPRRVSKYAAGLEQLNTGRKISPNPADWRCDETGVTENLWLNLSTGFIGSGRKNWDGSGGNGAALRHFEAGGRKYPLVVKLGTITPHGADVYSYAPDEDDMVEDPGLAQHLAHWGIDIMQMEKTEKTMSELQADLNTGYEFSRITEAGAALVPLAGPGHTGLINLGNSCYMNSVLQLLLTLPEVVGRYGGGAAAAGGGGGLFTSAPADPSNDLPTQLAKVAVALAQGRTGHVKPAEAEAAMEVDGEELVPLPDDERVTAVRPLSFKSCVGRGHPEFASGRQQDAAEYFTHLLELIARAEHTQAQRLGISGGGADVGSSADLGLLPLPTAFRFNLQDRVQCGESGAVSYKRQPHSLLMLQVPLEAATNSEAVAEYRDRQAKRQRLKEQSAQAYIGAAPEGATAGAAESAAVPAQVSGPGSGAAVVVVAEGEEEAVLPRVPFDACLQRFSGAEVVEDYRSAALGGRATTATKTTRFASFPPYLIMQVNRYFQDKDWTLKKMEVLVDVPDVIDLEPLRAPAGPAPGEVLQPEQQPEQQQQQQQQPAAAAQPAQAPAAAPQPDPALVAGLVDMGFGEAACARAAAAVSNAGLEAAMEWLLAHLEDPDINDPLPAPGAAPAAAAAPAAAAAAAAAEADPEKVSTLAGMGFSEEHAKAALQACSGSLERAADWLFNHMDDLDTAVAKVLSEAAGAAAAAAAAPAAVGAAGGSSGSAGSAPVVDGPGRYELVGFISHMGSNLACGHYVAHIKKDGRWAIYNDEKVAVSEHPPRDLGYLYLFRRLPAQQ
The following text describes a protein:
Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
NLRLLHKTTSMKKKRPLSELQTSILGENEENLFTNKPIEEEESENEEENEENAHSVAEESESDYSGLGEDEDSDSDDSMLGEEDSDVEEGEEVNEKSTEPTQHTEEKKETSEVVAKINEKLEKQTEDNDNDTSDEEDSRNTVGNIPMQWYEDFPHIGYDLDGKKIAKPIRNNDELDKFLDKMDNPEYWKTIHDKTTGRDHVLTEEELSLVNRVQRGYFYDAKYDPHEPYVDFFTNEKMLHPINNAPAHKRSFTPSLVEKRKVGKLVHAIKMGWLKVGKPKQDDEEQIKFYDLWADVNDDKKQKMHIPAPKPALPGHEASYNPPPEYLPTQEEIDQWKEDDPEDRKFDFIPEKHDALRRVPQYPKFIQERFARCLDLYLCPRQRKMKFNVNPDDLIPDLPKPRDLRPFPTVQALCYRGHQAMVRTISVDTTGQWLASGSDDGVVRIWEVQTARCVRELKIDEKEAIKCISWCPNTSVCLLAITVVCHIFTDVLLQNLVDTKIIILNPYIGDRLVAQATDSLLQSYEPNEEEEEQSGSKSEKSNSLIPPWRSVETGLEYQDGYRLVITHPKAVSKVTWHAKGDYFAATVPNNSNAQVFLHQLTKRRSQNPFSKCKGAVQSVLFHPNRPFFFVATQQYVRVYNLVKQQLSKKLLSNAKWISSIAIHPGALYKHTGDNLIVGSYDCRLSWFDMDLSSKPYRTMRYHKRAIRACCFHRKYPLFASAGDDGSIVVSHGMVYSDLMQNPLIVPVKVLKGHKVDRNLGVLDCCFHPHQPWIFSSAADNTIRLFS
The following text describes a protein:
Function:
Microtubule-binding motor protein which has ATPase activity. In complex with alpha and beta tubulins, preferentially binds to the growing microtubule plus-end to stabilize it and detaches following ATP hydrolysis. Negatively regulates axonal length through inhibiting microtubule polymerization at its plus-end.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Localizes to microtubules and to the growing microtubule plus-end.
Sequence:
MADTCVQVALRIRPQGNREKLEGSRVCTSVLPNDPQVTIGGDRSFTYDHVFDMPTLQYVVYESCVEKLVDGLFDGYNATVLAYGQTGSGKTHTMGTAFDAAVTQKEEDLGVIPRAIQHTFRKIAECKAQAIEQGLLEPAFEVSVQFVELYNDDVLDLLSDDRSMSSSIRIHEDSRGEIVLHGVEQRSVFDMHGTMDILKNGALNRTVAATNMNEQSSRSHAIFTLHLKQQRVAANPLDESGEQKTGELEMEMLCAKFHFVDLAGSERMKRTGATGDRAKEGISINVGLLALGNVIAALGGANGKVSHVPYRDSKLTRLLQDSLGGNSRTLMIACCSPSDSDFVETLNTMKYANRAKEIKNKVVANQDKSSKMIGELRSRIAALEAELLEFKQGRRTVDVDGHEVVNDQYHENVYLTSEVNHLRFRVKALNETLDILRTENIDLKAKQEFNSIASLPTAGSGGAEGEVDAIQSTFRKYLEELERTKSLLYESQSTCDQLRKDNARWKALGASRGSGGGNAEFNSQKLIEMAKQEVEKQRKLMESVNIGGENVSSEYSSMAQDEDGTSNEAEELLDEEDLDEDEDETAEEKQEQEESEALQIDLSEVMIELDIKEKLIDQLERAERQNQQIRETYEKKLRELMERIKDTETERDRVLNEGGKRGGNNEQMKAIKQEYELKITDLRKELKKIEALDKEHLKVIAKSQRELQEKTRLKSEVVDLKKAKVELIKKMNEDKKKQKTQQLANARAFATKEKQTRLQANKIRTLEMKDKQREQFLKKTTQEVNALRKEKAVAAATARQANRGTPRGGAAVTNSPARRVRGVVGGVQAIKELAFSAKASKVKWDVIVRKIEESARRRQIVQKMEAELERYLNERHAVMVEIVENEKQFTQSQDVIYRDGLLEAIDSAKQKLQYVQDQITYQQKLICDVDEDITASNAENEPILDVGLKKQTIKQLFDGCDTLSEARYLLQHLFDLCIDKAALAAKVESEFKECAARIEQLEQQSSLKEQLLTSIIEDKNLVDEIEGFVPSDLRKSRTSSQSSLLRSGSPSVVEDAHTLQNYKVRRHTATQEELLFANSEENSMVSDANANPTVDVGADVGDSDERKEKKKRIAFVSTSPASTSFANSTSQSPSFSRNTRFRSTVGGVSNNNNIRKSVQPLINGKGVSSTARKGISRLPSVTEDPEIGIFAKSFPGRSRSNLMSSSSSTTTTTLSSSNLLNPRGTTSSSSSKSVFARISPSWLSDTCAELIMRNNNRKQSRIVPVKDGMRGNVITRTHTLEGHARGVLSVDVNEKLMVTGSKDRTAKLWDIEACREIRTLGIHPNNVHLVKFVPFSNYVFTFSMFEARAWDYRTPECICVKVLNSSGQVNEGDSIDVSQVMPRQNTIPFLETLITAADVDPTGQLLFTSFSAYVRVWNLREWKPLGRLNAASHSPKSEVSCLRTTMTPEGSILAYTGSRDHYVKEYEVGLGTGVIESKCEFTPPHYDNVTAVLPLNGHLYTASKDVNIMKFSLKDGKREHLELRAHQQYIQSLTGFGPKGKELLVSACKDGTIRFWDVGSSSRMKLVEEYSKAHQEGINDMCSTKSMLFTASGDSTVGFWKSNAV
The following text describes a protein:
Function:
The major shell protein of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The shell probably limits the diffusion of CO(2) into and out of the carboxysome (Probable). Molecular modeling shows the central pore of this protein is selectively permeable to anions such as HCO(3) rather than CO(2) or O(2) (Probable). There are estimated to be 2970 CsoS1A/CsoS1C proteins per carboxysome (the proteins differ by only 1 residue) (Ref.5); Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.
Subcellular Localization:
Carboxysome. Note=This bacterium makes alpha-type carboxysomes.
Domain:
The tight homohexamer forms a pore with an opening of about 4 Angstroms in diameter which is positively charged.
Sequence:
MADVTGIALGMIETRGLVPAIEAADAMTKAAEVRLVGRQFVGGGYVTVLVRGETGAVNAAVRAGADACERVGDGLVAAHIIARVHSEVENILPKAPQA
The following text describes a protein:
Function:
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
Subcellular Localization:
Cytoplasm.
Sequence:
MDLRRAKVRILGEEYTILSEAEEDYIYSLSEEVDRKLRELGAGMPGASKQKLAILAALNFADELHQAKEIKDEPNSVSTKIGEVELEEKTRKLIMMLEEGIIGDL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
Sequence:
MMISCTRTAILPLRRRLMTASTAYPIKFASSIIPGYGRGSADLGIPTANIPIDDVPVLDALDTGIYYGLVQILKTDKPSEKKTSEFQKDRVVDFQYTNKLNDQEINAVLPMVMSVGWNPFYKNDQKSAEIHIIHKFAHTFYGASIKVMVLGYLRPEKNFTSLEALVDEIHNDIKVSEEKMEGTREKKDQFWQ
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSTLENTLQIEIKLEKEKTNQALLKDHVEKYSELTQSMSKILNSFEQRLGKLEHTILPVYNITKNLQKQQQNLDSTLQCMEQVLSHYDASQDVCNLIHQGPSEGNIGSFLDGLNKLKKAKDYFLNNNPQSVELENVTSLFNNGCETLNNHFKSLLKKHNAPLKPVDLLDMIYIEEDSSNEDCPSIKQVPPSAREELNVMAQWLDNNLRREYVQIFGDERSEVIMRSLQNLKDHQKSGSWGNEPLRTRHGYGRAEAGGKKTTSARLQQIFERKANKMFMKASQTLGQSAGLAMRKNSSFGDILAAEEYGNDNDQELEKYLVLLLGLQKLLVWERQLLNDIVPPSRHNEVFSRLSQPSIEMVVKDAEQITSKVMRSIGRKEWSAALGIFSALKHVQILQPDIDRICDSTQKQQLSGVLNRLQQTASKALEQFIESVRNDAGGGGMVSMTSSTISYGGGSSVPRDATVYELTSNTIWFLEQLQEHCDTIGGLLQTEAIYTNDLDRIASQKALTMEQKNKALLGIYVRKVLAELNYTIATKSEQYSDTATKQLFKLNNTHYILKSLQRSSLIEIVALTEHDCERRYQKMIQDLKKAYLGSWSKMLSFIHPLDDMPRPINGKVKDKERATIKDRFFNFNKELDEAVKIQRAISVPDVLLREGIKRDNTEHIVPKYNAFFEGYSDVQFSKNIDKYVKYRPSDVTTMLNSFFDDTV
The following text describes a protein:
Function:
Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
Subcellular Localization:
Endomembrane system.
Sequence:
MEQLKTIGRELAMGSQGVWGSSKEFLELVKTIGEAKSKAEEERIVLAEIESLKRRIQEPDVPRKKMKEYIMRLVYVEMLGHDASFGYIHAVKMTHDDNLLLKRSGYLAVTLFLNEDHDLIILIINTIQKDLKSDNYLVCCAALTAVCRLINEETIPAVLPQIVELLNHQKELVRKKAVMALHRFFQRSPSTVSHLFPAFQERLCDRDPSVMSAVLCALYDMILVNVKPFKHLVASLVSILKQAVEHRLPKSYDYHRTPAPFVQIKLLKILALLGTGDKAASENMFNVLGDILKRSDSTSNIGNAILYECVRTLTSIYTNPRLLQNAAEITAKFLKSDNHNLKYMGIDALGRLIKITPECAENHQLAVIDCLEDPDDTLKRKTLDLLYKMTKANNVEVIVERMVEYIRNISDNHYKTEISSRVIELAERYAPSNQWFIQTMNQVFEIAGDLVPQKVAHDLMRLIAEGAGEEDEDADSHLRSSAVQAYLQILKEPKLPSILLQVISWVLGEYGIADGSHSAEFIIGKLCDIVATRPGDDKLKGYVVSAITKICAFEKAAGQTVDLIPECVSFIEELYASHSTDLQQRIYEFHAVLKLDRDTIASILPMDASCEDIEVDKDLSFLNSFVESALANGSRPYLSDNERRGMGAMTTLASNNDAGTSSLLRFQPYEKPSIPEPAAALVTASHYSQDAIDQHDIYSKSSSNDGTRLKLEGVQKKWGRPTYTPEAQVPKNPINISDSVKVSSSAAGKEASSRNSSAPPYTERKQPSQEISAEKKKLAASLFGSKAGETKAKPAAKLQQNGTSKKAPAKPTSPPAPAPAPPPADLLDLSDSLPQIPSVDPVDQLADLISVDSSAATSTTSLVEQVLDAGKVATKGPSPQASLQKDSVSRQVGVTPSGGTNPDLFKDLFG
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MHQVFYQKYRPINFKQTLGQESIRKILVNAINRDKLPNGYIFSGERGTGKTTFAKIIAKAINCLNWDQIDVCNSCDVCKSINTNSAIDIVEIDAASKNGINDIRELVENVFNHPFTFKKKVYILDEAHMLTTQSWGGLLKTLEESPPYVLFIFTTTEFNKIPLTILSRCQSFFFKKITSDLILERLNDIAKKEKIKIEKDALIKIADLSQGSLRDGLSLLDQISNFSDSEKISITDVEKTFNIVDRNAKFTFIKAVLSGDIKEAFNLLDDFESNGLNFTYFLRELFALTVNLYAYAKLKNINVLDSTEKTMIETLNFEKQHYAFLIKAIEENTNFGLSQLTLIDRLKAIVISYNEFFNQKPLTISSPSNEKSLHLETEYLEKKKIKKSNHKQDQKHFSLFEKSFIDKSEKTPKNDEVTNNKFLDTSKLNLANIALAINAFNDNKWINHFQNLLSVFQTKFNDKDKQNNLSYFNNFIDKYSARDIVKATKIVKASSFGIVILFEDQKIAMRLWKEAIEEGNVQATIFQIFNQNLFLASFSEHQYKTTITEETKNQKYQTEVLNLTQLENLAKPFLKEKKRSLSQKMVDKYFKGLFEEK
The following text describes a protein:
Function:
Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates.
Subcellular Localization:
Cell projection, dendrite. Cell projection, dendritic spine. Cell projection, filopodium tip. Cell projection, growth cone. Chromosome, centromere. Cytoplasm, Stress granule. Cytoplasm, perinuclear region. Nucleus, nucleolus. Perikaryon. Postsynaptic cell membrane. Presynaptic cell membrane. Synapse, synaptosome.
Sequence:
MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPPPAGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVIYDSENHQLIILSINDVTTKRANMLIDMHFRSLRTKLSLILRNEEASKQLESSRQLASRFHEQFVVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSYLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENDKNIPQEEGMVPFVFVGTKDSITNATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGATSRPPPNRTDKEKGYMTDDGPGLGRGSRPYRNRGHSRRGPGYASGTNSEASNASETESDHRDELSDWSLAQAEEERDNYLRRGDGRRRGGGARGQGGRGRGGFKGNDEQSRTDNRQRNSRDAKGRTADGSLLIRIDCNNERSVHTKTLQNTSSEGSRLRTGKERNQKKEKADNADGQQPLVNGVP
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MATGGGSSVAGAGVAAEAEMKLECFDFAFNSERFSDRLLRIEVLAGDDGTEGSLPARARHRKEGDKRQRIDSPTTMVGTPVLRVKTLHINSAILAARSAFFLKCRQLLTSLMTTKSALLCLDHRCSISVTPEVQHVTSAAKQFLAKKYRDFEKSEIKVKEFPLAGIKAIFSSSDLRVSFEDNIYFFLRKWAFTRYRKSDERRKILSSRLLPLVRFSHMTGSALQKILTCTVTNTDHDLATKFVSEVLLHKGYPAQLQGSQAADATQSELTFTNL
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFQITPTRDLKVITDELQTLSSYIFHTNIVDDLNSLLTWMSPNDAKSNHQLRPPSLRIKNIIKVLFPNNATTSPYSMINTSQANNSIVNEGNTNKELQLQLFSTLKEFYIFQVRYHFFLHFNNINYLKDIQRWENYYEFPLRYVPIFDVNVNDWALELNSLRHYLLNRNIKFKNNLRTRLDKLIMDDDFDLADNLIQWLKSANGSLSSTELIVNALYSKINKFCEDNMSRVWNKRFMIMETFNKFINQYWSQFSKLVGCPEDDHELTTTVFNCFESNFLRIRTNEIFDICVLAYPDSKVTLLELRKIMKDFKDYTNIVTTFLSDFKKYILNPSVTTVDALLRYVKTIKAFLVLDPTGRCLHSITTFVKPYFQERKHLVNVLLYAMLDLPEEELKEKINFNVDMKALLSLVDTLHDSDINQDTNITKRDKNKKSPFLWNLKVKGKRELNKDLPIRHAMLYEHILNYYIAWVPEPNDMIPGNIKSSYIKTNLFEVLLDLFESREFFISEFRNLLTDRLFTLKFYTLDEKWTRCLKLIREKIVKFTETSHSNYITNGILGLLETTAPAADADQSNLNSIDVMLWDIKCSEELCRKMHEVAGLDPIIFPKFISLLYWKYNCDTQGSNDLAFHLPIDLERELQKYSDIYSQLKPGRKLQLCKDKGKVEIQLAFKDGRKLVLDVSLEQCSVINQFDSPNDEPICLSLEQLSESLNIAPPRLTHLLDFWIQKGVLLKENGTYSVIEHSEMDFDQAQKTAPMEIENSNYELHNDSEIERKYELTLQRSLPFIEGMLTNLGAMKLHKIHSFLKITVPKDWGYNRITLQQLEGYLNTLADEGRLKYIANGSYEIVKNGHKNS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA. m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity. Required for corpus callosum and cerebral cortex development (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGLYAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLEVGSRPGPASQLPRFVRVNTLKTCSDDVVDYFKRQGFSYQGRASSLDDLRALKGKHFLLDPLMPELLVFPAQTDLHEHPLYRAGHLILQDRASCLPAMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSPSDPRYHEVHYILLDPSCSGSGMPSRQLEEPGAGTPSPVRLHALAGFQQRALCHALTFPSLQRLVYSTCSLCQEENEDVVRDALQQNPGAFRLAPALPAWPHRGLSTFPGAEHCLRASPETTLSSGFFVAVIERVEVPR
The following text describes a protein:
Function:
Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle II (propionate degradation route). PrpF catalyzes the cis-trans isomerization of 2-methyl-aconitate through a base-catalyzed proton abstraction coupled with a rotation about C2-C3 bond of 2-methyl-aconitate.
Miscellaneous:
MISCELLANEOUS: Together with AcnD, they are able to restore the growth of prpD mutant on propionate.
Sequence:
MSNKLFPPQIKVAATYMRGGTSKGVFFRLQDLPEAAQVPGPARDALLLRVIGSPDPYAKQIDGMGGATSSTSKTVILSHSSKANHDVDYLFGQVSIDKPFVDWSGNCGNLTAAVGAFAISNGLIDAARIPRNGVCTVRIWQANIGKTIIAHVPITDGAVQETGDFELDGVTFPAAEVQIEFMNPAADDDGEGGCMFPTGNLVDVLEVPGIGRFNATMINAGIPTIFINAEDLGYTGTELQDDINSDNAALAKFETIRAHGALRMGLIKHIDEAASRQHTPKIAFVAPPKSYASSSGKTVAAEDVDLLVRALSMGKLHHAMMGTAAVAIGTAAAIPGTLVNLAAGGGEKEAVRFGHPSGTLRVGAQAVQENGEWTVIKAIMSRSARVLMEGFVRVPKP
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MSEPAGKRLKLTLPVCTAHRTLTGTRVKHNFPLVVEESLCGVITVLMAVAYRLQALAKLFERDDIALPRIAAFFHQEAEQEQKEAESLLEYLRERGGQYCNKDIQKPGCEAVGSVLQALELMLAQWKEVARILTELCQQSKQSGDPHTASVVKKRFVTPAIGKIEVVGCKDETGFGEYLIDQLQKELTNL
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRDWDCYRWITIFGGFVAFALACAAGANDVAASFGTSIGSGALSMTQATVMASLMEFIGATVMGDRNLDSMQFNLVSRLFYALDKLSHLRLVQLLTNVFAAVCLAFATYLELPVSSTLAVIGGIIGMALTARGLQAIYWNGRPVRNIGGVLEIILSWFLAPLIAAVASFLFFGFTKMIFLRSEHAGKRILQFMPVYYGLTVMVLIFFVIYKVSRGHFRLSGILATLLAFVSRFLSFVLIAVSEEPTQPIAIAVAPEKEAPPGPQDHSTQQQEQDMSPEEMIKQFNQLRVLDTVYEGEDEGNASPDVSVSLSVPQKIDYDRDVIVRHALAEKFDDKVEELFSFLQVLTACVASFAHGSNDVAAIMGPYAAVVQIFNHRPDVPNRDIDVWILAMAGIGVSLGFALFGWKLSRCLGGRLTFMTPSRGYSAQFCALATILFASRTELPVSTTHVVVGAIVGVGAADNIKNVNWKLAMAFVMAWIATLVSACGIAAALYSFTVFSPAYTVA
The following text describes a protein:
Function:
[Mature tail spike protein]: Receptor binding protein, which mediates the attachment to the host capsule. Degrades the alpha-2,8-linked polysialic acid of E.coli K1 capsule by cleaving within the polymer chain of polysialic acid; [Intramolecular chaperone]: The C-terminal chaperone protein mediates homotrimerization and proper folding of the catalytic endo-N trimer.
Subcellular Localization:
[Mature tail spike protein]: Virion. Note=Tail spike.
Sequence:
MSTITQFPSGNTQYRIEFDYLARTFVVVTLVNSSNPTLNRVLEVGRDYRFLNPTMIEMLVDQSGFDIVRIHRQTGTDLVVDFRNGSVLTASDLTTAELQAIHIAEEGRDQTVDLAKEYADAAGSSAGNAKDSEDEARRIAESIRAAGLIGYMTRRSFEKGYNVTTWSEVLLWEEDGDYYRWDGTLPKNVPAGSTPETSGGIGLGAWVSVGDAALRSQISNPEGAILYPELHRARWLDEKDARGWGAKGDGVTDDTAALTSALNDTPVGQKINGNGKTYKVTSLPDISRFINTRFVYERIPGQPLYYASEEFVQGELFKITDTPYYNAWPQDKAFVYENVIYAPYMGSDRHGVSRLHVSWVKSGDDGQTWSTPEWLTDLHPDYPTVNYHCMSMGVCRNRLFAMIETRTLAKNALTNCALWDRPMSRSLHLTGGITKAANQRYATIHVPDHGLFVGDFVNFSNSAVTGVSGDMTVATVIDKDNFTVLTPNQQTSDLNNAGKNWHMGTSFHKSPWRKTDLGLIPSVTEVHSFATIDNNGFAMGYHQGDVAPREVGLFYFPDAFNSPSNYVRRQIPSEYEPDASEPCIKYYDGVLYLITRGTRGDRLGSSLHRSRDIGQTWESLRFPHNVHHTTLPFAKVGDDLIMFGSERAENEWEAGAPDDRYKASYPRTFYARLNVNNWNADDIEWVNITDQIYQGGIVNSGVGVGSVVVKDNYIYYMFGGEDHFNPWTYGDNSAKDPFKSDGHPSDLYCYKMKIGPDNRVSRDFRYGAVPNRAVPVFFDTNGVRTVPAPMEFTGDLGLGHVTIRASTSSNIRSEVLMEGEYGFIGKSIPTDNPAGQRIIFCGGEGTSSTTGAQITLYGANNTDSRRIVYNGDEHLFQSADVKPYNDNVTALGGPSNRFTTAYLGSNPIVTSNGERKTEPVVFDDAFLDAWGDVHYIMYQWLDAVQLKGNDARIHFGVIAQQIRDVFIAHGLMDENSTNCRYAVLCYDKYPRMTDTVFSHNEIVEHTDEEGNVTTTEEPVYTEVVIHEEGEEWGVRPDGIFFAEAAYQRRKLERIEARLSALEQK
The following text describes a protein:
Function:
Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTKLGFTRSGGSKSGRTRRRLRRRLSGGVLLLIALTIAGGLAAVLTPTPQVAVADESSSALLRTGKQLFDTSCVSCHGANLQGVPDHGPSLIGVGEAAVYFQVSTGRMPAMRGEAQAPRKDPIFDEAQIDAIGAYVQANGGGPTVVRNPDGSIATQSLRGNDLGRGGDLFRLNCASCHNFTGKGGALSSGKYAPDLAPANEQQILTAMLTGPQNMPKFSNRQLSFEAKKDIIAYVKVATEARQPGGYLLGGFGPAPEGMAMWIIGMVAAIGLALWIGARS
The following text describes a protein:
Function:
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MDRNDPLQVHRDAFNIPKRRDGSDHVYLCGQTLGLQHKDVESSVAGALKRWRELGVLAEFQHPNPWAEVDRLGRKEIAEIVGAQESEVITMNSYTVNLHLLLIAFYKPKGNRRLVMMGNYALPNNVYAVMSQLEARGLNPAEDLITVCAPKDEDGKDSPAHIPMTEYLSIIDKRGSEIAVILLSALHFITGQLVDVQAITKAAHAKGIIVGVDCAHAVGNVPLKLHEWEVDFASWCTYRYLNSGPGNLAGAFVHTKHTQVGSELKTLRGCRGHEPRDLIDPSYKFEPAEGAAGFQLSNVSVLGMMALLPSVRLIAKVGMDSLREKSLLLTSYLELLLGELVPPGSIRLLTSVDPSQRGAQLTIRILPNKLSASLTPRASYGGESESDAECMERYLRDVGIIVSTCSTDLVFLAPVPLYNTFKDVLLAARAIAECF
The following text describes a protein:
Function:
Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by binding to VA. May act by serving as an adapter that bridges the presence of gaseous pheromone molecules, cVA, to activation of specific neuronal receptors expressed on T1 olfactory neurons, possibly via a specific conformational change induced by cVA that in turn activates T1 receptors. T1 neurons are excited by the pheromone VA, while T2 neurons are inhibited by alcohols. Also binds to phthalates.
Subcellular Localization:
Secreted.
Sequence:
MKHWKRRSSAVFAIVLQVLVLLLPDPAVAMTMEQFLTSLDMIRSGCAPKFKLKTEDLDRLRVGDFNFPPSQDLMCYTKCVSLMAGTVNKKGEFNAPKALAQLPHLVPPEMMEMSRKSVEACRDTHKQFKESCERVYQTAKCFSENADGQFMWP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGFLHVGQDGLELPTSGDPPASASQSAGITGVSHRTQPPCFEGLTSKDLVREEKTRKRKRKAKESGMALLQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDTSSKCMMKMFSSTGQGNTEVVHTGTLQIHASHHIGDTCFQEIEKDIHDFVFQWQENETNGHEALMTKTKKLMSSTERHDQRHAGNKPIKNELGSSFHSHLPEVHIFHPEGKIGNQVEKAINDAFSVSASQRISCRPKTRISNKYRNNFLQSSLLTQKREVHTREKSFQRNESGKAFNGSSLLKKHQIIHLGDKQYKCDVCGKDFHQKRYLACHRCHTGENPYTCNECGKTFSHNSALLVHKAIHTGEKPYKCNECGKVFNQQSNLARHHRVHTGEKPYKCEECDKVFSRKSHLERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHTVIHTGEKPYKCNECGKTFVQNSSLVMHKVIHTGEKRYKCNECGKVFNHKSNLACHRRLHTGEKPYKCNECGKVFNRKSNLERHHRLHTGKKS
The following text describes a protein:
Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Subcellular Localization:
Secreted.
Sequence:
MNGGLCLCVLMAVLAAGTLAQPVPPADSAVPGAQEEEAHRRQLRAVQKVDGESRAHLGALLARYIQQARKAPSGRVSMIKNLQSLDPSHRISDRDYMGWMDFGRRSAEEYEYTS