lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Subcellular Localization:
Cytoplasm.
Sequence:
MSILTNIFHRDSDSSELSISDHSDCSVQYDLAPASIEPRIGTLHTHLISHAPSRSITIHEDTAGGCGGRTWPAATILSNYISHRRLLGTFPYSRIIELGAGTGLVSLTVAVLPNEQSVLRSSELAPTAPVSITITDLEEFVPLISFNAKLNLTEQELKTISIETCRWGDPLSQHIKAAFPFDLILVADCVYLEAAFDPLIKTLTDLSTRSTEIWIAFKKRRSADRHFWTRLAKTFHVEPITDDPNHHDYSRKRLFLYKAMLKSPFTKNTVASTKTVQALS
The following text describes a protein:
Function:
Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26-hydroxycholest-4-en-3-one diastereomers to the corresponding carboxylic acid which is a prerequisite for entry into the beta-oxidation pathway. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
Sequence:
MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG
The following text describes a protein:
Function:
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLKSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MSDSMEEPATPAATRGGVGSHGGSAMRGEDFTTFIKALTEKYGLFEKTSRIKPPQLSFDKTPQQSGRKHSPEGQLSSHAQGTVSIKDGVSIADVKSKTEGKPELSAGPPQTRRTGRIESPDLNATSKLDIPGLRLGVSDAMPGGHPAATAPHHLSDASQDPINHAMETQLSPSLSQSPTLPTSGSEASFTRHRASHRQAWHSKEPHEDSIDGNTDILSEPRGQANEASNTSALPSPSSPAGNTLAPFTRPVLYQDQASGQASSQPPLLPGRSPRRPPRWLPLLTSIEAEARLSDIGGGERMREPDAEATPGADGEASQADGTAPETMLEPSAASAETPHGGMLKRFQEASTSELEGSKASAGVSPPGDGGHSQAHDQESADDERERQAGSQPGGWSALNRSLRDNGFGSLRSPQEPGFFVDVHAVFKDLLKQYERRGAMVQELLGANESAKEAQSQQQADLQRLAHEKETLESKVEVLEHQAKEAAEGVDQAGANLAERIRKLESANASLQQRCSQLQHLARAKERTAQKLQDKLEETVLKEEKRRSREKDIYEKLKRKLASDARGRGWGDLGKAAAVAARELQPTVLVGLYEAQREATDAELSMLRKELAAVHAELRDKDNLIMRKDRAGGWKTLEVGVLLEKQMAAEKAASEEALALAALEASLAEKQQDANRRVADATKRAEQLAEENANLRLELEARPSVRDFRETQRLLSRLTRKIEDMRKQQGTWSDSDSEEDALEEAELDGAVARKQERLRPTRERIARDRNVHRLRLKKLDKLPKDVLLEALQDVCIQVEAAELSQLTSSVDKMLRVMAAVPKMERFISDVCSIVFLEGPPPNSSNGSNGQRSPDAVPSILRGWIETLGKVRELEEFQAVIATELGQRPEGRQTVQGPNLARNCAAAVKELVGLEREFLLKEATFRQAEGLVLADPERLIHKMLAHFQRLFEVPRLDGVFARINAVYSQYSEHHNFLRALRSLLGLPDNAGTGACIARIRALLDQDGRARALVPEYVLGEKRNGAAAGASASGRPAEEPTGDKVGRREVVNKLLRLFHQSDEKQLVAHCETILSRLQRHTQVLPRYQSVVNELYDLLRVATLDAIVPAVRALKHV
The following text describes a protein:
Function:
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium.
Subcellular Localization:
Secreted.
Sequence:
MWKALSLTLALCLLVGCSAESETEGARCKLPPEWKVGDVEPMKNALGQVTVVAYLQASULFCLEQASKLNDLLLKLENQGYPNIAYMVVNNREERSQRLHHLLQERLLNITLYAQDLSQPDAWQAVNAEKDDILVYDRCGRLTYHLSLPYTILSHPHVEEAIKHTYCDRICGECSLESSAQLEECKKATEEVNKPVEEEPRQDHGHHEHGHHEHQGEAERHRHGHHHPHHHHHHHRGQQQVDVDQQVLSQVDFGQVAVETPMMKRPUAKHSRUKVQYSUQQGADSPVASUCUHURQLFGGEGNGRVAGLUHCDEPLPASUPUQGLKEQDNHIKETUQURPAPPAEUELSQPTUVUPAGDATUGURKK
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
Subcellular Localization:
Membrane. Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MRRRLRLLAAALGGCGLLLGSALAAGDERLYTAAVMPALRVVTPEAAHGLALRAAALGLLPPARPDSPSLEVHVLGLRFRNPLGLAAGFDKHGEAVDGLYRMGFGFVEVGTVTPEPQEGNPKPRVFRLVEDEAVINRYGFNSHGHAAVERRLRARQEAQLKLTTVGMPLGVNLGKNKSSTDAAADYVAGVQTLGPLADYLVVNVSSPNTPGLRDLQGKAELRDLLTKVLAERDMLPSERKPAVLVKIAPDLTEQDKQDIAGVVCECQTAVVLVLLKGTADLQCWLAGGTTLCLAVGLRVCVHPIRPLGLQVVRDDYWVGVDGLIVSNTTTSRPRGLQSTQRLEAGGLSGKPLRELSTQTVREMYALTQGRVPIIGVGGVSSGRDALEKIRAGASLVQMYTALVYHGPPVVRTVKRELEELLREQGFKSVMEAVGADHRR
The following text describes a protein:
Function:
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Sequence:
MVVSNHYTVHLKFTVLYVNYIAINLEEKKNTQRRAKQSQNTQIFKLWSQGTVGPRRSGPSFLGQQAAAQVVVACCEGINISGNFYRNKLKYLAFFRKRMNTNPCRGPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPATLKVVCLKPTRKFAYLGCLAHQVGWKYQAVTATLEKRKEKAKIHYQKKKQLMRLWK
The following text describes a protein:
Function:
Endosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS). Efficiently hydrolyzes sulfate groups from a broad range of substrate size, including disaccharide to high molecular weight CS and DS polymers. Has a strict specificity for the 4-O-sulfate groups of galactosamine. GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract.
Sequence:
MGGLTLFAAQGCKAPKQVAEQAEHPNIIYVFPDQYRNQAMGFWNQEGFRDKVNFRGDPVHTPNIDTFARESMVLTSAQSNCPLSSPHRGMLLTGMYPNRSGVPLNCNSTRPISSLRDDAECIGDVFSKAGYDCAYFGKLHADFPTPNDPENPGQYVETQRPVWDAYTPKEQRHGFNYWYSYGTFDEHKNPHYWDTDGKRHDPKEWSPLHESGKVVSYLKNEGNVRDTKKPFFIMVGMNPPHSPYRSLNDCEEQDFNLYKDQPLDSLLIRPNVDLNMKKAESVRYYFASVTGVDRAFGQILEALKQLGLDKNTVVIFASDHGETMCSQRTDDPKNSPYSESMNIPFLVRFPGKIQPRVDDLLLSAPDIMPTVLGLCGLGDSIPSEVQGRNFAPLFFDEKAEIVRPAGALYIQNLDGEKDKDGLVQSYFPSSRGIKTARYTLALYIDRKTKQLKKSLLFDDVNDPYQLNNLPLDENKEVVEQLYREMGTMLKEIDDPWYTEKILSDRIPY
The following text describes a protein:
Function:
Probable transcription factor. Binds to the sequence motif 5'-ATAAT-3' in regulatory elements. Required for development of the anterior hypodermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. Modulates and maintains dopaminergic neuron differentiation. May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-40 and ceh-20.
Subcellular Localization:
Nucleus.
Sequence:
MDPSKGFEYVAGDYYQTSGVAPPTSNGAGSNVSPYFPYHAYPTSSTNGATGGSMYGTPQQTSAYAMYPPGPGSSPEEAFPEHTTTKIVEGCEAKYNVKGKKMRKPRTIYNSSQLQMLQKKFQKTQYLALPDRAALAHELGLSQTQVKIWFQNRRSKQKKQKGGSSDHASDEEDDDTEESKPESPPMGESVMIQESSEPRTLVSSSIKTEMKEEYPPMTLNEQYASPYLYGSDFSTILPPSQGFPNNALYNTAGAYPSIDYTNGVYQNTLYKYV
The following text describes a protein:
Function:
Part of the ABC transporter complex NrtABCD involved in nitrate uptake. The complex is probably also involved in nitrite transport. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MASSTAGLRPRRKKNPLSFIYSPKVIRPAVAIAVLLVVWQILCSGEGSNLPSPVQVLEQTYPLILNPFFDNGGTDKGLGIQIFASLTRVAVGFSAAAVVGIALGILIGSSKFMYDALDPIFQVLRTIPPLAWLPIALAALQEAEPSAIFVIFITAIWPIVINTTVGAQQVPQDYRNVSRVLKLSKSQYFFNILFPAAVPYIFTGLRIGIGLSWLAIVAAEMLIGGVGIGFFIWDAYNSSLISEIIIALIYVGIVGLLLDRFIAFLESLVVPAEQK
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MTRTSSSKPFPSTRRKERDIGDGGGKRFSVFDFSEEDARVEKVSRRLLGKFSARRSSPVTKHQFLHCFGKGAKSVSRNLSDELIDIDAEVGKSANIDSFSEDVSDELIHIDSEGHQISPGPTDLNAEDTCADTPLEGGGSMKQEILETNDILLSRSSTNEDDVTVIFPDFVIYEGNWCTTSKLIFSCSCIKFRGSALSGLQRTFDSEWAISDIIGIESEWCSRVETAIVNLCLKGKHFTRAENSKDISGIELLKFSVCDPLWSESEKAIRTLNLRYNDLWNADHDDNDKVNGEEIVSWRHSDVFSPKNCFSEFVDTFEEVIYPMGDPDAVTISKRDLELLKPGMFINDTIIDFYVKYLKNKFLSEKNNRFYFFNSFFFRKLVDLDKDLSSARGGRDAFQRVHKWTKKVNLFQKDYLFIPVNYSLHWSLVVICHPGEVVNLKDKKHDNLSKVPCILHMDSIKGSHRGLKSLFQSYLCEEWKERYGDGDYKDISAVFLTLPFIPLELPQQENSFDCGLFLLHYVELFLEGAPVNFSSLKILKFSNFLSQDWFHPAEASLKRAHILKLIYEIMACNQAKELSGSIGKYPSSDANDSDNDLSKHVSGQAHIFTMTHSDNFSSVGKEVGSVSKVSSDTNYQPIGRWESVMPPIEEDENGERADSPQCLEDRPQASTVSECSSAFSFGQQFTELEICWEGRYSKNVKEMCRKPSPRLSLHELQTPLELGQPEILTSSSDELINCVVEDSEEEGNERNERIEIQVSSSSSSSSRNNLFLSRQVVESPAKFSRQHQHK
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLTKRAVSPVNLSRGTIPSTIHRDELQCTANGTIANLVRQLSSLSKHAENIFGEIYHDAMIINHKSNTLQQRIDRLHKKVEDLDSNSDQATLNEANMRKAFKSSMLVDQHILDRSTLPTALTEIYAKCDPPPDLDALNPYRDSEIPALSLYTNPSFFFDLWKKETLKEVAERPRRVKSPNDGSKSPKKRRKQPGQGPLGTTAYNDMQHRNRQISGSRINQQNEVFSFPEEYQAPQALGLQLNFKNQHPSNMVAPIGMTMHHHPQQNVHPSQQRGGAPAAARGSPNVKRPTEAPPPVNLDHLPPPDMSILSIDDDDDDLPPPPPPLLMNTSIVHQLPAEAPSTIQFVEPSAAPPTNIPPPPPPPPPMVISSAAASFAAPAPKPSADGEAAGTNSPVAPKQPDARSDLLAQIQSGIKLKKVQRAEAEAAENAALEANNVAAILKRRMDQVMGNDDSSSEEGADDDEWDD
The following text describes a protein:
Function:
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MTQKGSMKPVKKKKTEEPELEPLCCCEYIDRNGEKNHVATCLCDCQDLDEGCDRWITCKSLQPETCERIMDTISDRLRIPWLRGAKKVNISIIPPLVLLPVFLHVASWHFLLGVVVLTSLPVLALWYYYLTHRRKEQTLFFLSLGLFSLGYMYYVFLQEVVPKGRVGPVQLAVLTCGLFLILLALHRAKKNPGYLSNPASGDRSLSSSQLECLSRKGQEKTKGFPGADMSGSLNNRTTKDDPKGSSKMPAGSPTKAKEDWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQAFILALLIFLLTSVYGITLTLDTICRDRSVFTALFYCPGVYANYSSALSFTCVWYSVIITAGMAYIFLIQLINISYNVTEREVQQALRQKTGRRLLCGLIVDTGLLG
The following text describes a protein:
Function:
Endonuclease involved in nonstop mRNA decay via the formation of mRNA cleavage fragments in the vicinity of stalled ribosomes.
Miscellaneous:
MISCELLANEOUS: Present with 2130 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Note=localizes to the proximity of the head region of the ribosomal 40S subunit (hr40S).
Sequence:
MKGTGGVVVGTQNPVRDYNHSTDEEYQRLRRLADEAYKKRDQLSHESQTAYQQGDKKLAHELSEKSKAQLKTAEDFNMQAAEYVFVENNADSSSNEIDLHGLYVKEALFILQKRIKFAIDHNEPQLNVIVGKGLHSQNGIAKLKPSIEEFCAKHGIRNHLEKGNSGVLVLELQGVQMQMDGPAVNAPTNQYNAQPHPQYNNNGGQPQGQAQNYNNSGNDNKDSTLTSIFKIFCNCIQSLA
The following text describes a protein:
Function:
Seems to be involved in the regulation of AidB.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPVLQWGMLCVLSLLLSIGFLAVHLPAALLLGPMIAGIIFSMRGITLQLPRSAFLAAQAILGCMIAQNLTGSILTTLAVNWPIVLAILLVTLLSSAIVGWLLVRYSSLPGNTGAWGSSPGGAAAMVAMAQDYGADIRLVAFMQYLRVLFVAGAAVLVTRMMLGDNAEAVNQHIVWFPPVSINLLLTILLAVVAGTVGCLLRLPSGTMLIPMLAGAVLQSGQLITIELPEWLLAMAYMAIGWRIGLGFDKQILLRALRPLPQILLSIFALLAICAGMAWGLTRFMHIDFMTAYLATSPGGLDTVAVIAAGSNADMALIMAMQTLRLFSILLTGPAIARFISTYAPKRSA
The following text describes a protein:
Function:
Serves as a ruler that controls the length of tail by stopping the tail tube polymerization and is probably released from the tail shaft during infection to facilitate DNA translocation into the host cell. Assembles into a multimeric linear form possibly stabilized by the covering tail assembly proteins G and GT. Its C-terminus fixes the tail tip complex (J, I, L, K), thereby forming the tail assembly initiator complex. Tail tube proteins polymerize around tape measure protein, displacing the tail assembly protein G and GT. When the tail reaches the length specified by the tape measure protein, it stops and becomes capped by the tail terminator protein (Probable). Upon tail assembly, tape measure protein is cleaved into a form called H*, that plays a role later during virion entry in a new cell (Probable). Once assembled, the virion is released and can infect new cells by binding to the entry receptor LambB (Probable). After opening of a pore on the external membrane, the entry protein H* protein is probably released in the periplasmic space for successful DNA injection.
Subcellular Localization:
Virion. Note=There are 6 copies of entry protein H* per mature phage.
Sequence:
MAEPVGDLVVDLSLDAARFDEQMARVRRHFSGTESDAKKTAAVVEQSLSRQALAAQKAGISVGQYKAAMRMLPAQFTDVATQLAGGQSPWLILLQQGGQVKDSFGGMIPMFRGLAGAITLPMVGATSLAVATGALAYAWYQGNSTLSDFNKTLVLSGNQAGLTADRMLVLSRAGQAAGLTFNQTSESLSALVKAGVSGEAQIASISQSVARFSSASGVEVDKVAEAFGKLTTDPTSGLTAMARQFHNVSAEQIAYVAQLQRSGDEAGALQAANEAATKGFDDQTRRLKENMGTLETWADRTARAFKSMWDAVLDIGRPDTAQEMLIKAEAAYKKADDIWNLRKDDYFVNDEARARYWDDREKARLALEAARKKAEQQTQQDKNAQQQSDTEASRLKYTEEAQKAYERLQTPLEKYTARQEELNKALKDGKILQADYNTLMAAAKKDYEATLKKPKQSSVKVSAGDRQEDSAHAALLTLQAELRTLEKHAGANEKISQQRRDLWKAESQFAVLEEAAQRRQLSAQEKSLLAHKDETLEYKRQLAALGDKVTYQERLNALAQQADKFAQQQRAKRAAIDAKSRGLTDRQAEREATEQRLKEQYGDNPLALNNVMSEQKKTWAAEDQLRGNWMAGLKSGWSEWEESATDSMSQVKSAATQTFDGIAQNMAAMLTGSEQNWRSFTRSVLSMMTEILLKQAMVGIVGSIGSAIGGAVGGGASASGGTAIQAAAAKFHFATGGFTGTGGKYEPAGIVHRGEFVFTKEATSRIGVGNLYRLMRGYATGGYVGTPGSMADSRSQASGTFEQNNHVVINNDGTNGQIGPAALKAVYDMARKGARDEIQTQMRDGGLFSGGGR
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MADVMMMNDIDERAAAAGIDLSQLDLSSIHLSPGENFGIISDDEDVHQREQLDFEAGFNNIIVVDNLPVVPKEKFEKLEGVIRKIYSQIGVIKEDGLWMPVDPETQKTLGYCFIEYNTPQEAELAKEKTNGYKLDRAHIFAVNMFEDFDRFMRVPDEWAPPEFRPYVPGENLQHWLTDEKARDQFVIRAGSDTEVFWNDARQLKPDPVYKRAYWTESFVQWSPLGTYLATVHRQGAAVWGGASAFNRLMRYAHPQVKLIDFSPGEKYLVTYSSHEPSNPHDANRIVINIFDVRTGKVMRDFKGSADEFAIGGTGGVAGVSWPIFRWGGGKDDKYFARMGKNMISVYETETFSLIDKKSMKVENIMDFSWSPTDPILALFVPELAGGNQPARVSLVQIPSKEEMRQKNLFSVNDCKMYWQSNGDYLAVKVDRYTKSRRTTYTGFELFRIKERDIPIEVLELDNKNDKIIAFAWEPKGHRFAVIHGDSPRPDVSFYSMRTAHNTGRVSKLTTLKGKQANALFWSPAGHYLILAGLKGFNGQLEFYNVDELETMATTEHFMATDIDWDPTGRYVATSVTSVHHEMENGFNIWSFNGKLLYRILKDHFFQFLWRPRPPSFLSAEKEEEIANNLKKYSKKYEAEDQDVSLQLSEQDREKRRMLKDDWEKWVNEWKLQHEEEKLERQKLRDGEASDEEEEYEAKEVEVEELLDVSEEVLSFEFGQE
The following text describes a protein:
Function:
Guanine exchange factor that acts as an activator of arf1 at the trans-Golgi net-work and is thus involved in vesicular budding and traffic between compartments of the Golgi apparatus (Probable). Activation of Arf (ADP-ribosylation factor) GTPases is essential for vesicle formation via recruitment of cargo adapters and coat proteins necessary for Golgi trafficking (Probable). Involved in the resistance to tamoxifen (TAM), an anticancer drug used to treat estrogen receptor (ER)-positive breast cancer.
Subcellular Localization:
Cytoplasm. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, COPI-coated vesicle membrane. Cytoplasmic vesicle, COPII-coated vesicle membrane.
Domain:
The homology upstream of Sec7 (HUS) box is necessary for the allosteric activation of Ssec71; The homology downstream of Sec7 (HDS) domain 1 is required for recruitment to the trans-Golgi network via its interaction with activated arf11.
Sequence:
MQDASEPVINMPALPMNSVNEQHDRHEDLPEVGTTSVTKIINDSDNEDDENGMDLGRVASESLEGDAVVSIDINTEDSSLSPAKQENEKSPEGIEQKYQEEDLKDDKKSNETIATPVPDAASRASLEKQKSGLTNLEKSTHVVLIKCIEQLIQIKVCMKNEKMKNLMEQLKPLLQTECQFDKFLIVELFQYCFESSQDEVMNISLDTISKLASFAYFSSKDKTPASFGPPKSLLQCMVDMVCDSINDEVVDGNLQLNVVKALSAFILCSEQDSMLHGAILLNSVRKLFNVFLLGDSDTIQSVAQASLTQAVTVVYERLRASHTQSNSTSALPEEDASVTENWVHDEDEPDKKITLHSMASAGTSSLDHVKVDADDPAVTSVENSSIQDAFLVFRSMCRLAVRQTSPDKVSNIRSQAMRAKLISLHLIYRILEKNSDLFMDPTLQFRGIPALKGMTLVHASRQYICLVLSRNAVSPVPQVFEVCCDIFYLMVFSLRAHFKQEIEVFFREVYFPMLDLKNTSYNQKLHTLLIIQRICLNPRALVELYINYDCDRSSTTNVFEQLLFSISKVTTNGPSETISEDIEEILPSLESSERSSTPFLNTNSASLKSEVVQLTTFSDFQLKLKTLQCVLDILQSLSNWAESGLYLSRRGVSTDEQGFVGDYDALSRSDTPVTNPYYNGKQSFEANSHSSSSIALADPSQFESNKQRKKLLRTCINKFNYKPTRGLKMLSENEYVDINDPKAIAEFLFRADGIDKTTLGDYLGEGDEKSISVMHEFIDCLSFINLKFVDALRRLLQCFRLPGEAQKIDRIMLKFSERYMKENPSAFANADTAYILAYSIILLNTDLHSPRIKNKMTKEDFIKNNRGINDGADLDEDYLGFVYDDILKNEIAMKDDQELAAIAPLMNNFSTSSGFTTFTSNGRDLQRVACIQASEEMANKATSVLKKLLYQQKHGSQKTNVYYNATHFEHIGPMLEATWMPILAALSNPLQNSDYVNELNMCLDGFQLVVRIACLFDLDLIRDAFIKTLTNFTNLHSTSEIKLRNTMVIKTLLRIASTEGNNLKDSWKDILTIISQLERVQLIGVGVDETEVPDVINARVRRKNVNIGSSNSIRHVSGSTSRSTRTRSLSKPLSPEAVSELMSTEVVLSIDRIFTQTSSLSGSAIVSFFKALCEVSWDEITSSSDLEQPRLYSLQKLVEISYYNMQRIRVEWSSIWNVLGRFFNMVGSDENRHVAVFALDSLRQLSMHFLEIEELSLFSFQKEFLKPFEYVMASDTVVEVKELVLQCVKQMIQAKISKIKSGWKTLFGVFTFAAKARSEILISMTFDTLVNLFSEHYDTLMQQNCLIDMLISFTELCKNGTNQKISLQSLEIIREVYSSLSTMIKEGLSSKPSVNETFSKYVFPVLFAYYDIIMSAEDLEVRSRALQNLFYIFLEESDDFTEETWEVVSRKFIFPIFSIFGPEADEATVMLRDEEIRTWQSTTLVEALRSLVTLLTRRFDKLHNLLKGYLWLFSNCICRDNITLSRIGTNCMQQLLSGNAYRFEVKDWNLVADMFIELFKETTPHQLLLLETFSNGQGAPVYSENENTQLSHKRGGSLPETSRSISTSSISPEKQMEFRSMIRKCILQLLLISIVAELLDNEEVFNHIPHEHVLKITVAIYDSWQFARKFNEDKSLRITLLNVGFMKQLPNLLRQETASALLYITLLFRLLKTRDPLGKTETDQKIHKLLFPVCAEMLDMYASLVVEKHTRNHAAWQPVIATILDSILNLPLELFSENIHTLYFSCCSMIAKENLDDQLRELLKNYFNRVGHILLNLNAQQE
The following text describes a protein:
Function:
Involved in metal homeostasis. Specifically binds Cu(2+). The truncated isoform has less specificity in metal binding.
Miscellaneous:
MISCELLANEOUS: Knockout lines indicate that CUTA is not essential for copper tolerance or accumulation.
Subcellular Localization:
Plastid, chloroplast intermembrane space.
Domain:
A central prokaryotic signal-sequence-like domain may be used to export the protein to the chloroplast envelope after import into the stroma.
Sequence:
MASSLTTRLSAVIGSRRSFPIVGAFCVLSTLSISSLSSSSPFKSGCAQSFSVVPLLRSKFSSKAFSSSIRMEESSKTVPSIVVYVTVPNREAGKKLANSIVQEKLAACVNIVPGIESVYEWEGKVQSDSEELLIIKTRQSLLEPLTEHVNANHEYDVPEVIALPITGGSDKYLEWLKNSTRN
The following text describes a protein:
Function:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Sequence:
MTSNQKAILAGGCFWGLQDLIRNQPGVVSTRVGYSGGNIPNATYRNHGTHAEAVEIIFDPTVTDYRTLLEFFFQIHDPTTKDRQGNDRGTSYRSAIFYFDEQQKRIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHFVRPGWRLPRRTAESALRASLSPELGT
The following text describes a protein:
Function:
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MKKFGVAAFDEVTRDYETLGINFDRQNQELKEQLTIFQERLAEFAKDNNKELRANPELRVKVLKMCSKIGIDPLLIFDKDKHLFHVDDYYYELCVKVIEICRRTKDLNGGIIAFEDLHRGYFKGTKVQVDDLEKAISMMKSLDGGFEVFIIKGKKYLRSVPNELTGDQTKILEICSILGHASIALLRANLEWKSVRSKAVLEEMVAKGLLWIDEQADGETLYWDPAWIMRTY
The following text describes a protein:
Function:
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular Localization:
Secreted.
Sequence:
MVSFSYLLLACSAIGALAAPVESEDTSFNETALHEFAERGGTPSSTGWNNGYYYSFWTDGGGDVTYTNGAGGSYSVNWRNVGNFVGGKGWNPGSARTINYGGSFNPSGNGYLAVYGWTTNPLIEYYVVESYGTYNPSSGGTFKGTVNTDGGTYNIYTAVRYNAPSIEGTKTFTQYWSVRTSKRAGGTVTMANHFNAWSRLGMNLGTHNYQIVATEGYQSSGSSSITVY
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MAALGQEEYPSLATLLQDVYQRRKNLLQVVELLGPSLTSTDTDKRCSAVQLLSSLLQKLVNYKLTDREDLKPVGSDLVFGFLQAMDGEKDPRNLVVAFKLARIIIKNFPIGLFAEDLFEVTSCYFPIDFTPFCLPLLMEKLSSDVINAKIDSLLTLVFQTVSSELEDAAFKALSSIIKNLESSSPGQEPFLSRIFINFYTISCYVTQCHPDVVEFKTPFLDCVIKECCANIEGADLRKVKPSGQLLQAAFVTDTTYNEITSTAVPLILSKYNDEATQGLVKKLLLDVLLGLLTASKPYYKRKGSVLASHTSALVDVLFSALVSDSPSLCRAAIAGLVSMVTLPGLLLEQKVGMFVEHLTSFVLNTKDLTVRQESNAALAFLAMEFPELIKTKLVSVLAEQLQKEDGSAMDEENISHLQSDKSHPQYDQMLNTLSAVCTEEGVVRHVVPIILDHGEYLVTGKDLERGVLHGKISETLKCLNSIVKGTLQSSTVEPNYYTEVVIYRIIDLCTQSALQESPDCPMATPEALALVCSIVRQVISHLAVNEAEDVLHIIVSNFIEGKTPLSARAEQKFAPLEPSSPWQQSQLVTVLMAAVCSARREVRIPRQKELVPRLQVLASGCNHRKTTVAASKCLGGIINKMAQGDDLTADLHSLKGQLQNHMDGNEEQRWRAVITWLWLTRALVTRSHPMAQEFVQKVLHLLDDVSVGRVAADGFYVIVSDCDDVMNQAMHADIKMMYKQRFFMETLPLLLKGFHDTRPECKYLYLCALSHLLQWIPKQVLLTEIPTLMPMLIQALSRDEPSLLLSTLQTLYSLVFDAPEVISRQVTSLIPNFLELAKCKASMKVRMEAIKCLGAMTTLEHHVVYVYKARVIKELACTLDDPKRLVRAEAVKCRNEW
The following text describes a protein:
Function:
May play a role in cilium morphogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm.
Sequence:
MALASNPRRRLHEVRVQKYVVIAVTWRGAQPMSQRARPSRVVRAAAWGMFARCHPGAAAGWHRCTDLVTRSSARPAYTVASQSFSQGLVEDAPLQNPNTLTYNRVYSKVGNTRILQAEPAVLNFGGYELGKVYSQVLRIRNVRASGTRFHIIPPSTPFFKATCPAKKGLLAPGMTEEVAVEFCPTQYRYYYDCVRVHCEEENLLIPLHAYPVANEALFPTRVDFGRVALGQEVVRSHTLECKVPVDFEYEIVEVKPNPAFRVEPARGVVPGRGRVTVDMWFCPLALTTEEAVIETEVAGVYVPDTMLLSAAEVGLRTKDVRGAIEARKAAAAEQQAALEKGALFRLQLALAEEAARKVALGTAPHSGQQLLTAEQPELEAGGAVHQPSAPVGSSSSGGGGGSDPAFKPEHKRTRVLDKFMRAVWRVVTHQRLQRRLERIKEVLAHLGYDKQRLAEEAANPVLLVSESDRPGTAPTKYLRPEMVRVRPLPLYRDVLFQVHHATDLSHYTDFDELAPFTSKVRERLVPSGLVPPLSDYPTMPDACKNMPYITLEIGNRYGDDRVYGAPDPSYSPYGSLDVDYAVQPRQYDVYDSARHEAVASGGVRSLRGGPGLSDSWLVRQICPAVPTDEQLAKCGGTGIVNTIPN