lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a pleiotropic drug pump at the plasma membrane to clear toxic substances from the cytosol. Organic anion transporter involved in the detoxification of a wide range of toxic environmental organic anions that contain carboxyl groups. Required for tolerance to reveromycin A, tautomycin and leptomycin B. Required for oligomycin resistance. Required for rhodamine B resistance. Mediates the ATP-dependent efflux of rhodamine B. Involved in cadmium detoxification. Displays an energy-dependent efflux of cadmium and glutathione, suggesting that YOR1 transports both compounds as a bis-glutathionato-cadmium Cd-(GS)(2) complex. Confers resistance to rhodamine 6G and to doxorubicin.
Miscellaneous:
MISCELLANEOUS: Present with 3610 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTITVGDAVSETELENKSQNVVLSPKASASSDISTDVDKDTSSSWDDKSLLPTGEYIVDRNKPQTYLNSDDIEKVTESDIFPQKRLFSFLHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYYFEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYFMSIVFAILANCTSGFNPMITKRLIEFVEEKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNHFFHTSQLTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVNLGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPGNIFASLSLFQVLSLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGFDPKLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGYPWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRVIVLGTDGQVDIGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGKIVADGHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAILVVGTTFCSLFSSVWLSYWTENKFKNRPPSFYMGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSMCSRSGIVENDFENRS
The following text describes a protein:
Function:
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Miscellaneous:
MISCELLANEOUS: Calcium is required for ligand binding.
Subcellular Localization:
[Isoform H1a]: Membrane; Single-pass type II membrane protein; [Isoform H1b]: Secreted.
Sequence:
MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVIIENLIKAIFSALLGYLFGSFLPGYFLPLWFKKVDIRKLGDGNPGVLNVKRSIGIFPAILTAIYDVSKGFVSMILLKYLFNFPNFFVYLGGFSAVLGHKFPFYLGFRGGRGFATSLSLFIFLFFKLLIQNFASFQILQFFIFLIVYFLLLNTATHGVGDVFTITAFPIIALFMLINTKSLLDTIFLAILAGVISYEAVKNLLRDGFRFYTEKHTFWRILARPFALLFIPIYVFFSKFIVLLVIGGILGIFFLLDMLRILVRRMEDFFQLRGVKNFKIFKEKEVGRISSITNFLLGIFISFILFEKEIAFASLGFTSLGDMMAKWIGINFGKTKIFKNSEKTLEGSLGFFSMALVVSFFLWFKGMISLYVLLVGTIVAFIVEAIPNPIDDNFSVPIISGAVMEFIKKYF
The following text describes a protein:
Function:
Functions as a GTPase. May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body.
Sequence:
MGRKRAPGSGGGGGGLGRSLIKERNLQNRSQRRRDTWLHTRDMDDELWARAAPRSVTEPTALEDFLATAQLAGTEFVAEKLNVHFVPPEARTGLLSLEEKQRLRERQEEHRGALQVPRRPRWDQSTSAEKLQQMEREKFLEWRRGLVRLEEEQSLILTPFERNLDFWRQLWRVIERSDVVVQIVDARNPLLFRCEDLERYVKEIDRDKENVILINKADLLTAGQRAAWATFFEREEVRVIFWSALAEGDRLRAGSEVARPAGHSGMGSRGRHCRDDYNWLSEEGDSEYEDCLEEEDNWQTCSEEEDGGGHEEEFLSPSGPGKEAGDGPVRNDSHLVGRQELLDLFRAMHSGKKVKAGQLTVGLVGYPNVGKSSTINTIFGNKKVSVSATPGHTKHFQLSRVHSLSLRGEGLLRAQLLPLRPHVCQNIPRHVLEATYGIRLIRPREDEDPDRQPTSEELLTAYGSMRGFMTAHGQPDQPRAARYILKDYVKGKLLFCHPPPGIEPGNFQEQHECPRQSRGRPQAAAEARWPERGHPKARQIENVVDRAFFHQENVRALTRGVQAVMGHRPGGAPGPSASPHGGSGKPWKKHGNRNKKEKVRRLTGHLDA
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
Sequence:
MPDLKSKTLSSQSLGAAIPPEIVYQILTYQFRDLLRNDHPGTAEKFNENLTTFVKSNLTVNKTFSHICQVLIYRYCNLTTAKRFHGLLQTLKGNRCLCNKIEVADFQELTSIGLGRSSEMNKMIKNLTNETLLEFLMLTKANLREFLACENIQDDLDDNIIKYILSPGKVLSVVDFCGCSGTTFTESFIKALDKYYPNKSIDQYRLEPIQQNYQITCLGLNDCIDLPSHVLWKILKMLPELQKLDLSHTSIDDSTLYHGIPHWKNLTHLSLATCLQVTPRAVLEFFSHHPTITDPDNTSTLEWLNVSVIAHSSSWNEVHTMFLLKKLCQHGHNKTLQYLNIGGLPLHVAPSFGEDPISESTYYYQCRDSLQFIKWNFPKLKSLSIKGNSIPISTLVEFLTPIDQDHPNCAQKLKFLNISGNSYVNKWTIQDSLLYTCSPSLVALEVSFDSWQQIEKLNDRHEIIAYRYKNPNSVIKDISTAEQVKWKCYIDSSYGRRYWLYKTDPFLNRDDLDSKSNLTRYDFEGHKIIEIINQPDFLKFAQSKIMLGCGLVPQSGIRRKLCYRDLKPPVSQFLNRKGAISLGDTPLPIITPTLPRGGWRIIHNEDDNNSHVEDSQNHVNAIPRRNSLLSRPTLRSNNGSSSANPFAINVSPASQIRDGLYWDRSVHDLRELSLQEQRIQELADEQQELRTIANFEETDDEYLHDPDLQRRRSQLHLFESSRSRSGNKTRPSLTGEHSSSASFLSFSHFNHLHKRKNYYFTHPDEFVYDPKDPLTTQRYRLHFEIVNEYQVFGCIERGMYRYYSLKA
The following text describes a protein:
Function:
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence:
MSDQEEEYEGEEEVEEEVEEEVEEEVEEEAEPEPEPEPEPEPEPEPEPEQAKPKPKFIPSTYEQPKYEGDEDVEARFGQMADKRRQKDHVELEEFIKKHFEKRAKEEEELQLLIVRREKRKAEMADKETARKERERERVNEEKARLMKQREEEERKRKEEDDRKKKLANVNLHIGGYLSRLEGKEKGPSKRQLAQEAKRKKIMARVKALPDLGTLSDHELREKAQELQDRLKFSEEELYDMKDKVQRQVYDMDRLRTTINEAMGKFNKPGTAGGAQRGRVAGKFGK
The following text describes a protein:
Function:
Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Microsome. Cytoplasm, cytosol. Note=Highly concentrated in the perinuclear area of the endoplasmic reticulum (ER) and surrounding lipid droplets. May be associated with the specific regions of the LR that form lipid droplets and targeted to the initial deposits of lipids where the lipid droplets form.
Sequence:
MDALVLFLQLLVLLLTLPLHLLALLGCWQPICKTYFPYFMAMLTARSYKKMESKKRELFSQIKDLKGTSGNVALLELGCGTGANFQFYPQGCKVTCVDPNPNFEKFLTKSMAENRHLQYERFIVAYGENMKQLADSSMDVVVCTLVLCSVQSPRKVLQEVQRVLRPGGLLFFWEHVAEPQGSRAFLWQRVLEPTWKHIGDGCHLTRETWKDIERAQFSEVQLEWQPPPFRWLPVGPHIMGKAVK
The following text describes a protein:
Function:
Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development.
Subcellular Localization:
Cytoplasm, P-body.
Domain:
The UBA domain is not required for correct subcellular location, gene silencing or interaction with pAbp; The RRM domain lacks RNA-binding properties and does not bind RNA in vitro. It is not required for P-body localization or for interaction with AGO1 or miRNAs but is required for silencing. May play a role in protein-protein interactions.
Sequence:
MREALFSQDGWGCQHVNQDTNWEVPSSPEPANKDAPGPPMWKPSINNGTDLWESNLRNGGQPAAQQVPKPSWGHTPSSNLGGTWGEDDDGADSSSVWTGGAVSNAGSGAAVGVNQAGVNVGPGGVVSSGGPQWGQGVVGVGLGSTGGNGSSNITGSSGVATGSSGNSSNAGNGWGDPREIRPLGVGGSMDIRNVEHRGGNGSGATSSDPRDIRMIDPRDPIRGDPRGISGRLNGTSEMWGHHPQMSHNQLQGINKMVGQSVATASTSVGTSGSGIGPGGPGPSTVSGNIPTQWGPAQPVSVGVSGPKDMSKQISGWEEPSPPPQRRSIPNYDDGTSLWGQQTRVPAASGHWKDMTDSIGRSSHLMRGQSQTGGIGIAGVGNSNVPVGANPSNPISSVVGPQARIPSVGGVQHKPDGGAMWVHSGNVGGRNNVAAVTTWGDDTHSVNVGAPSSGSVSSNNWVDDKSNSTLAQNSWSDPAPVGVSWGNKQSKPPSNSASSGWSTAAGVVDGVDLGSEWNTHGGIIGKSQQQQKLAGLNVGMVNVINAEIIKQSKQYRILVENGFKKEDVERALVIANMNIEEAADMLRANSSLSMDGWRRHDESLGSYADHNSSTSSGGFAGRYPVNSGQPSMSFPHNNLMNNMGGTAVTGGNNNTNMTALQVQKYLNQGQHGVAVGPQAVGNSSAVSVGFGQNTSNAAVAGAASVNIAANTNNQPSGQQIRMLGQQIQLAIHSGFISSQILTQPLTQTTLNLLNQLLSNIKHLQAAQQSLTRGGNVNPMAVNVAISKYKQQIQNLQNQINAQQAVYVKQQNMQPTSQQQQPQQQQLPSVHLSNSGNDYLRGHDAINNLQSNFSELNINKPSGYQGASNQQSRLNQWKLPVLDKEINSDSTEFSRAPGATKQNLTANTSNINSLGLQNDSTWSTGRSIGDGWPDPSSDNENKDWSVAQPTSAATAYTDLVQEFEPGKPWKGSQIKSIEDDPSITPGSVARSPLSINSTPKDADIFANTGKNSPTDLPPLSLSSSTWSFNPNQNYPSHSWSDNSQQCTATSELWTSPLNKSSSRGPPPGLTANSNKSANSNASTPTTITGGANGWLQPRSGGVQTTNTNWTGGNTTWGSSWLLLKNLTAQIDGPTLRTLCMQHGPLVSFHPYLNQGIALCKYTTREEANKAQMALNNCVLANTTIFAESPSENEVQSIMQHLPQTPSSTSSSGTSGGNVGGVGTSANNANSGSAACLSGNNSGNGNGSASGAGSGNNGNSSCNNSAAGGGSSSNNTITTVANSNLVGSSGSVSNSSGVTANSSTVSVVSCTASGNSINGAGTANSSGSKSSANNLASGQSSASNLTNSTNSTWRQTSQNQALQSQSRPSGREADFDYISLVYSIVDD
The following text describes a protein:
Function:
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Plays an essential role in the completion of conidial maturation and is essential for trehalose biogenesis in conidia. Negatively regulates expression of the melanin biosynthetic gene cluster. Also plays an a role in the early phase of fungal growth including proper hyphal branching.
Sequence:
MFAQPFDHAFNDLFSQYVDMDSSMVDGNKDVSIPSDFDQIFSLDSLSSDCGDHSPPVPTKPTHQSPQPWATDLWSLPQDAASSASQCSFTFQDTVHPSAVSDLSFHLEAPPTSHPVPAVTCKASSRSPSTPPATPHHKSTKSALVTPKSIRRHRDSHERKLLRKQSFSPSLMRPSQLQAGRMMYPEAWAQRFQNFSLHSSGEHLPLSPPPSDILVQHENTPADNVVTHMNHSTEGLSRNPAEMPSHYETGIFNQSPAISMPSPSAKLLAQQQQHNYLSQSNNSTMATSSPPSGDDIFSSPHSSDPQSLSSWHSDSLGGSALPFTPELQAHDGQAWWPSMPSRVPRQPSYQHVVSSPAPQRSIQSNNQHDLMQGGLMIQFDSSFDGSTSADPSFSSVVTSAPMPQENQNMYSHIPVTPQKYMNLSAYATPPVQHTSRSPSLSPRGRGSPTQGSPLRNEASTKTSPHRRGYHGRKLSSQSMNTPKPVKGPNSSSPGSGSNKSLTVSFVNFTPNDSKKILTGVAPSGSSKTKARREQEARDRRRKLSEAAINAVRKAGGDVEALEAVLC
The following text describes a protein:
Function:
Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Mettl14, constitutes the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. During oogenesis, required for egg chamber development probably as part of the N/Notch signaling.
Subcellular Localization:
Nucleus.
Domain:
Gate loop 1 and gate loop 2 regions are adjacent to the S-adenosyl-L-homocysteine-binding site and display large conformational changes upon ligand-binding. They may play an important role in adenosine recognition. The interface loop contributes to the heterodimer interaction.
Sequence:
MADAWDIKSLKTKRNTLREKLEKRKKERIEILSDIQEDLTNPKKELVEADLEVQKEVLQALSSCSLALPIVSTQVVEKIAGSSLEMVNFILGKLANQGAIVIRNVTIGTEAGCEIISVQPKELKEILEDTNDTCQQKEEEAKRKLEVDDVDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREKQSKQVGEEILELLTKPTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAGENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDESLGDCSFLNTCFHMATCKYVHYEVDTLPHINTNKPTDVKTKLSLKRSVDSSCTLYPPQWIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRAMELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQKRYPDGNCMSPASANAASINGIQK
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSDDAAAGLVRVLDAAQGAFLALDSYGGNDRSRAVLAMAEALERSFAQILEANTLDLVVSREMSVADCLCEWLKLTPERLQNTVTILKRLASLPDPLQRVMASPYQFNLAQTYCQLMPLGVVALVYESFPELAAIAAGFCLKTGNSLVLRSCGASSHSTAAICEILREGLLDADLPVDSVSHIPSETSPNVQDLVGNASQLNLVIPYGRPSFVEQISQQCTPPVLKAAMGNCYLYWSSKGDLEMVRQMIIDSHVGHPDPVNAIEKVLVSPGQNPAPLVRLLNNLQAKGFKLRGDAELCEQFPDHLTLAKENEWGKAYLDRTVAFRTTQNLKTAIAWINSHSSGHGDCIATDSYQESRQFSMGVDSALVYVNIPPYFCRNPRHGESLFLGVSSQKGQRRGLIGLEAFMTPKQIVQGESRS
The following text describes a protein:
Function:
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Melanosome.
Sequence:
MSFCMCAKFLNEDIFFQSGRDLQQYQSQAKQLFRKLNEQSPTRCTLEAGAMTFHYIIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKKVPTVSRPYSFIEFDTYIQKTKKLYIDSRARRNLGSINTELQDVQRIMVANIEEVLQRGEALSALDSKANNLSSLSKKYRQDAKYLNMRSTYAKLAAVAVFFIMLIVFFPGFSRESRKEKEMARQRKSGRWEEGSSSYLLGSGFTSDTYKVVTLTSSLEIFLEPNTLGRNALKIIWKWQHL
The following text describes a protein:
Function:
Involved in transcriptional regulation. It is able to activate transcription from CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MASPRELDEESPVYLVVSGIPAVLRSAQLRSYFSQFREQRGGGFLCFHYRHRPERGPPQASPEAARAGPDPAAEDPVLAQAPASDARAVRARGSAAAQTRTCCCVVSVRGAAQAQRLLRMYSGRRWLDSQGTWLPGRCLIRRLRLPTEVSDLGSFPFKTRKELQSRRAENEAFTLADLKQLPELNPPVLMPNGNVGTPLRVFLELIRSCRLPPRIITQLQLQFPKTGSSRRYGNVPFLYEDSETVEQEEHVYTAEGEEIPQGSCSEDPAAGSFDEPEDEGQQQEEEEESGSEEDDDRGEEWERHEALHEDVTGQERTTERLFEEEIELKWEKGGSGLVFYTDAQFWQEEEGDFDEQTADDWDVDMSVYYDRDGGDKDARDSVQMRLERRLREGQEDGSVLGGQVGTFERHTKGIGRKVMERQGWAEGQGLGSRCSGVPEALDGDGQHPRCKRGLGYHGEKLQPFRQLKRPRRTGLGLISTIYDEPLPQDQGETLLRRQPPTSMKFRTDMTFVKGSSCALDRPEPE
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFSQRYDPLAEENNGSRPADSGFGVSLKKRKLSDDESSDEEEEEEETDESEHESSQDEDINEEEPEEEDEDTNKVDDNMEIDSQPEVDPDYIHKHQAIFNKFKQSTESETIEQDKEEDGEEDANIEQHSLVPLPQPALPRDRKLSSVSTHTKNLDWLTKPQYASPSDKKAFTDFKSSSFMIKNLEKMGFTEAFSVQISVLNMMLPEIEAQKLKPDRVGDILVNASTGSGKTLAYSIPIIESLYRRVVPRVRVIILVPTKPLINQVKSTLLQLSSGTNLQIAALKNDVSINDEKDSLTKSVPDIIVSTPGRLVEHLLNDSINLSSLQYLIIDEADRLLNQSFQNWSNVLLDKIDSQINIAEVWKLSVQKLVFSATLTTDAGKLSSLKFYNPRLIIVNDSKQLVNEIFTVPVTLSEFKIHLGVAKNSLKPLILTKFLISTNKLSNVLIFTKSNESSIRLTELLTSLFQKLSINLKIAFINSTNNRTSIRSKILKQFSNQEVNILITTDLIARGIDVASITDVINYDLPNSSREYVHRVGRTARANQVGYAYSFCFGKGENSWFKKLAHEVSRSKEVENVDLNVKELISDRDEEIYQQALHELQQQAKK
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side.
Sequence:
MFGLNKTPSFGSTGTQNQNTGTSAGTGLFSSNTFGNNTQANTPASTGFGGVTGGAFGQTKPQTGGSLFGNKPNATSTTPGLNLFGQNPQAAPGGSLFGASTTKPQAPGGLFNQNQTQAQPAQAAPTGGLFGLSGQNQTQSQTQPAQANTSLFGQSNIGTTGGLFDQNRPNTSTFGQFSTQPASAGLFGQSTQPSGSTGFGLSNNTQTTPFFSAAQQQPSTTQLPSNPAINATTRYSSLNANTQKFLDDLDKEIFSQIQLAEELQTKLGTVSELVESVPNDVAEVQRRLSSVSTALLIDSDEIETTKRVVDEDTSNARISSRILDVFKTPGATYPFASNDPLMNYFEQFTENAKKRTDLYAATIGELEQHLEQVETTPQNNSPEALLKTIKEEHKLFMALSNRFAQVHDEVKRLQVNTSTSLPFIS
The following text describes a protein:
Function:
Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates. Acts on propionate 3-nitronate (P3N), the presumed physiological substrate. Probably functions in the detoxification of P3N, a metabolic poison produced by plants and fungi as a defense mechanism.
Sequence:
MGFKPLKIGKLISNIPIIQGGMGIGVSGYNLASAVANAGAIGVISAAQIGYREKDFKTNTKEANIRALRKEIRKARELSPEGILGVNIMVAMNNYEELVNVCLEEKIDIIISGAGLPLKLPSYIKDSDIKIVPIVSSKKATTIIIKQWIKKYDKLPDLIIVEGPLAGGHLGFKYDDLNNEELNLGNILKDVLEEVRIYEDKFHINIPVIAAGGIYERKDIKKFLELGASGVQIATRFIATKECDAHINFKKALINCKEQDIKIIKSPVGLPGRAIKNAFVNKVCKARINPEFCFKCLKSCNPKETPYCISKALIEAVKGNLEEGLIFTGSNGYRINKITTVKDLIRELTENI
The following text describes a protein:
Function:
Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling; Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2.
Subcellular Localization:
Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQEVFRRVSIADPAALGFIISPWSLLLLPSGSVSFTDENVCSQDLRAFTAPEVLQSHSLTSLSDVEKVHIYSLGMTLYWGADHEVPQSQPIKLGDHLNSILLGMCEDVLYARVSVRTVLDACSAHIRNSNCAPSFSYVKQLVKLVLGNISGTDPLSHSSEEKPDRSQAIRDRLRGKGLPIGRSSTSDALDTHKAPLSQQTFLNKGLSKSMGFLSVRDTQEEEDYSKEIPSDNNSRHEDSEPFSSPYQFKTSSPHIDVLSKKKTWASSMDLLCAADRDLSGEIGRYQHCDPETGTGRTSITSRKKEGRYSDGSIALDVFGPQKAEPVIHSRELPASSAVSSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHSDLFSTSSESPSIISSDSDFRQVRKSEASKRFESSSGLPGVDDTVQSRPSRQYETSLEGSLINQEMMLRRQEEEMMQLQARMALRQSRLSLYPGDTIKTSMLDISRDPLREMALETAMTQRKLRNFFGPEFVKTTVEPFASLDLPRSILLQTKKGKSEEQRKKVNIMLLSGQRLELTCDTKTVCRDVFDMVVAHIGLVEHHLFALATLKENEYFFVDPDLKLTKVAPEGWKEEPKRKGKAAVDFTLFFRIKFFMDDVSLIQHSLTCHQYYLQLRKDLLEERIHCDDEASLLLASLALQAEYGDYQPEVHGLSYFRLEHYLPARVMEKLDMSYIKEELPKLHNTYAGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDSSKACQYLLQLCSSQHKFQLQMRARQSNQDAQDLDSLHKRWSTVSSPEREITLVNLKKDLKHGLGFQIVGGGKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPTKVPSTPVHFANGMKNYTKKPSSMQDSAMDPSEDQPWPRGPLRHVPESPFGLSSGLREGSLSSQDSRTESASLSQSHVNGFFTSHLGDRGWQEPQHSSPSPPVTSKITEKTFSDSYRSPARRQGTCDVTELPGCADSDIDDPTYSSSQDRQAPKQEPSSPLKASDKMSFAAFPGPSPEPGDAFEVELAKTDGSLGISVTGGVNTSVRHGGIYVKAVIPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSRERDPASPRCPTPDQDAQSQAPEKMEKQTAHVKDYSFVTEDNTFEVKLFKNSSGLGFSFSREDNLTPELINGSIVRVKKLFPGQPAAESGKINVGDVILKVNGAPLKGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEVNTALLTPLHSPAHAFLNSRKEHSQPSPLSVEQCASSDENGLSGQSKRQCKPPSRRESYSDHSDSGEEESVRAAAKMPNVIPLSAFAPEALRSQGEPASTMFYLPRKIPGKPESESSRLPHPLDVSPGQIRQPPAECAPSDSPGKHLTHLASQLHKEENMTALKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLRPGDRLVKVNDADVTNMTHTDAVNLLRAAPKTVRLVIGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGRGSPHGVVYISDINPRSAAAVDCSLQLLDIIHYVNGVSTHGMTLEEANRALDLSLPSVVLKVTRDGCPVVPCSTRSAISALRPLEANGLSSMEPYGQPALTPKKSFSKVNGDGASGAMCPGGKGLSSPRKKSADLMEARESDSRDDDVYDDPQEAEVIQSLLDVVDEEAQNLLNQTKASRRACSPDPLRTNGEASEDGEDTDCDGSPLPEDVPESVNGGGGKACFASLIQASQEEKPVKEEATQESRESTTETTDREDSSKDPLFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGDEGGYINASFIRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRLALLRMQQLKGFVVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSHPEDLLTFISYMRHIRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVVLYVLTHLQAEEQKAQPGLPQ
The following text describes a protein:
Function:
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG.
Subcellular Localization:
Mitochondrion.
Sequence:
MTASPTEYAFEMIQSTLRFGRGVTAEVGYDIRNLGAKHTVVVTDVNVAKTRAFKQVADSLTRLGQKFTVFEDVQVEPSDKSMKRAIDFARSGRFDSFIAVGGGSVMDTAKAAALYTSNPQDDFLDFIVPPFGLAKIPDRPMLPLIAIPTTAGTGSETTGVSVMDLPEHNCKTAIRLRCLKPLLAIVDPLNVMSLPRNVAIYSGFDVLCHALESYTALPYNERTPRPATPQERPLYQGSNPISDVWSLEALRVMEKYFRRSIFDPSDEEARTHMLMASSFAGVGFGNAGVHLCHGLSYPISSQGKKYTDPDYPQQKALIPHGLSVVTTAVADFEFTISACPDRHANAAKALGADIPISSSNEYISRKLCDQIRGFMSDFKVPNGLGALGFSSSDLPKLTDAATSIAPRKTDRDAVAAIYEKSMKIY
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDHAEHAADAADTDAPEGDDAGGDDGEQAGDDGTSALSERVRALDADNADALADDVAALEARVETLTDELADAEDEVADLTERVQTKQADFKNYKERAKRKQEEIRERATEDLVERLLDVRDNLDRALDQEESESDEDGIREGVELTRDEFDRVLETEGVTEIRPEPGDSVDAARHEVMMRVDSDQPAGTIVDVYRPGYEMSGRVVRAAQVTVSEE