lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPARFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDNPLCTTDDIMKIVKGPDFPTGGIIQGIDGIRKAYQTGKGRVVVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLFKNTDLQVSYNFNMVAINKKRPELMGIIPMLDAYIEHQKEIITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSKDKRDAKLNLQTKYDFSEKQAEAIVSLQLYRLTNTDIHELQSEAKSLAEQISVLEKILGDEAELIAVLKEELAEIKKKYKTARRTEVQAEIAEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHAIFIQKMNSLDSLLLFTSKGNFIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAIQAFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKLKGDDELLSVHLIDGTEDIFLATKNGYGLRYSITEIPESGARTAGVKAINLKQDDIVIGGIVLMPNEQKHILLATQRGSLKQMKASEFEPISRAKRGLLMLRELKSNPHRFIGITLADNNDHLFIETNTDQIVEIDVANLRITDRYSNGSFVLDETMEGEPTSIWLAIPEIKDTSDAKEE
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MHVEKLNYLLAPLPTHPRVCSRFPLVLPRAGGQSGGAARGGARSGNVPGAAQSLSAASGCTAMGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDAPESMGGPGGTGGGSSSGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECDRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRTFILFNKMLSFTFSSNPPSASL
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MNVAAILSLFHTIWAVPMLLLSTAPRTSEDVSRFEVLSLPDSPTLPRSWAGRLPIPDTEEGNSIFFWLFEAQDPGYDENLIIWFNGGPGCSSLIGLMTGNGPVLLDSNTTHLIENPQSWTKLGHVLYVDQPAGTGFSTASNPYPVRDNDRVTSDFYKWLQSFFSHFPNFRSKRVHMIGESYAGIYIPYFAYAIAENQDNYPIDLRSISLGDGTLGNPAAMTAVTVGTFLKSRKSLLQIPGEILSAFTQADQTCGFTTVLQQASQFPPKGKFEIVGDPENLNYKHRHRRHRFQQDQRRNLRNVMNETCNNHPTTPEQVSSSILNSTCYGSCATYSTAMNYLNAVSAAGTGKRCFDVYDITNDCTMIDPLGLMASYLSRGDVQAALNLSPAPAGLAFAPCNSTILDTLLLAVPPTPPAYTILPSLVTEHNISVHVYSGDNDLLLNHLGTELVLQNMTWGGAQGFSRKPSRIFYVDDAAPSLHGADACNVSVSHDSTGLSEGAQRCVPAGIWASERGVTYHLFRGAGHSVFIKKPREMFAYVRDVVVAQASG
The following text describes a protein:
Function:
Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Involved in distinct membrane trafficking and signal transduction pathways. Highly active against a range of soluble and lipid inositol phosphates. Active in dephosphorylating the 5-position of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 and to a lesser extent Ins(1,4,5,6)P4 (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MQCYLKRKERSVAFITEKYAAIIQKPSVKDSDCIITFTCISLEEFEKIKEYELLFGGEKILGTLGLFNYVCEDMKEGVFLCVARKAKLVLRIGNRDPISKLENVSFISLDQELWDEELFEPMPRNSSPSSTFSTSTSDLNNIEKDNLVNSEYSSKYSSTTRIYPYHSLSQLTDLLTDGSFYVSTNISCFSRFQSEQPYGPKDIYCWNRFLITELDNHFSEAHILEKFPNLLLHCFRGYVERMFIDSMSMSIISKVSSYGSRQTYPPSGIDDSSYCSMFVETEFIVEIAQTVFSFVQVRGTVPCFWEEQFSSWYGPSISFLRSSQASQSLFNFHFSKLYKAYGDIYVIDLLQTKGFEASLYEAYKHHLMLLPFPAVVKKFHFTPDPARPDIDPRLETDLADDLKEMGYTQKSIENDMLESFQKGVFRINDLDCLGRTNVIQYQISRLVLKDIFFNLQIGVTFNILEYLRHLWSNNGDAIAKLITGVGSIGSSATRRGRKSIAGSLSDISKSFGRMYVGRYPDVESQNAILLLLGCFPNQSPVLISESVSSYIQGVLRQRRSEYRVERDFSIFSSTFNANGKVPSTDEFKRLLLPFGERTSAYDLYVVAVQEIITLNMSHLVSSSNQKLRIWEEKILMILNSRDSNNKYMLISSIQMAGVFLGVFIRKDDHLVVSKVTKTTRKTGFGGFSANKGAVAIEMNVCDSDFCFVSSHFAPKVNNISERNMEYTSISDNLVFPSGMKIYDHTNILWMGDFNYRIDSDNEEVRKLVELDDLDKLASYDQLCTEMKKGTVFHGLVEPQLTFLPTYKFDNGTNDYDTSDKQRVPSWTDRILATKSFTRNCYKSCDIRCSDHRPVFATFSLKIFSTCMDKKAGIIRDARIAYIKSKNSNK
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGGLPELGSKISLISKADIRYEGRLYTVDPQECTIALSSVRSFGTEDRDTQFQIAPQSQIYDYILFRGSDIKDIRVVNNHTLPHHNDPAIMQAQLQNGPPQMPQHFPMPSGMSGPPQQQQVPSQQPPQMPSGGGSGGAGGAGAPGGGGPGYGNGNPFGNLGGPNLANMVGNAGGSLAPGSGAPGSGPFMHIGGNQQQPKPQQQKQPNMLAGASRSTTPISLIVSPTAELTQQQQLHQQQNAGQGGNGRDAGHKRQNHQQQQNQQHQQRGGPSHNNMQQQQQRGGGSGTDFYNQQRDRRDSGRQMDNNYSNNYNNNNNNQRNRGGGNGMQQQQRGGNGGSGGGGGNGGGNNPAWNMHRGNQNSNNMMNMRNRGMGSRGPMRPNQGYRPQSANNQNKPRNKIKFEGDFDFEQANNKFEELRSQLAKLKVAEDGAPKPATNATAATATATNEQLNGETDKKDDSGNETGAGEHEPEEDDVAVCYDKTKSFFDNISCEAAQDRSKNKKNDWRQERKLNTETFGVSSTRRGSYRGRNQYYNNNGNGGINSGYGGAPGYNRNNYRMGGGGGNFRNRSNNRNNGGGRGGNGMPNITNGNTAAALKAANNAAGHGSNATDSSAPNATTATTKSTSLLPEQTQQVAAVSQ
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSIDVNWRFATSGPDGEALAERIRSFIHDRFQQVALPRFIRSVQVHAFDFGTIPPELEIKDFCEPFADFYEEDDDDHTSDASEERGEEHSSRWNSTHPELNEPSYREDTAVNHSLRDPFPDGFPTSPLRSPLGEHLNPHFLPRASTPGIPGGTSTLGYHLMSLGGLSGTQTPLAAVAGGNPFASGWSDSGMGPGNRGRSETHAGMQHPRAEPEIDTSNSTSRPSTANTLPSHPSGSSKNSGQAATGRNDHPSLHAGEHLEDSVTQGQLPLPPRMRERRPEDFQVLCHVKYAGDVRLSLTAEILLDYPMPSFVGLPLKLNVTGITFDGVAVIAYIRKRVHFCFLSAEDADALIGPEQQQQRESAGDDHRPQSRPDSSASASQKRHGGLLQEIRVESEIGRKEDGKQVLKNVGKVERFVLAQVRRIFEEELVYPSFWTFLI
The following text describes a protein:
Function:
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Sequence:
MEDKLLEYNMTDPSSESEEVETWISHYCSSTGHDYFVEVFEDFIEDDFNLTGLMFLVPYYKEALEMILDLEPEDPLKVPSIPMFEHSAELLYGLIHARFLLTKTGLQIMAKKYDEAQFGTCPRYYCDGTRLLPTGRHDLPGYESVRLYCPCCCDVYVPPNSRYLNVDGAFFGTSFVGLFLKMFPEVERNCIPLRKNIYELKLFGFRINEMSYSGPRMKWLRQYPEDPSVLDEEDKLPPPRTDEKDDDGDVKLETDQENRA
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Sequence:
MPTVPSFIPKPKKLTPENDPLHIIKTRRITHNRPATIAGPMVRYSKLPFRQLCRHFNVDIVYSPMILAREFVRNEHARMADFTTNSRDTPLIVQVGVNNVVDLLRFVEMVSPYCDGIGINCGCPIREQVREGIGSALIYNQPLLCEMVRAVKEKYKDTVRLETKIRIHDDLAQTVTLCNALASAGVDWITIHGRTRTTRSSVPANIAAIRYIKEHITDKELPIVANGDCFTLDDCHRIAAETGADGIMAVRGLLANPALFSGYKTCPWHAVELLWHYAMEFGTLPYQLLQHHLHCMLENMGADKTLLKQMMDIKNFCELIDWFDEHFVLRRKSQEELSDIPDIPYRHRAPRP
The following text describes a protein:
Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTDPLDLSLDLLRRLPPSKVEQNLESIVKLIPSYADDLYSSVDQPLKVKLDESKQGASREFLCCDYNKDGNSWRSWISDTYHPPIPPGADDTVDGESGTRPSAPLRSLELKANDAFETYARLYYDNALSSVYLWDLDSDPSSLPGATVGGIHAPSAFAGVVLLKKTIGQDRGNGISGAWDSIHVFEATERASGGSKSSSSGTGISASYKLTSTVMLSLIRRDESTEEPTDIQSSSAKVGTVEIAGSLTRQSEADYALPDFVSHVSNVGRMIEDMEAKMRNQLQEVYFGKTRDVVSHLRSTQSLEKERRARDLQKELMGLWKK
The following text describes a protein:
Function:
Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to ssRNAs and dsRNAs in vitro. Also functions as a replication enhancer.
Subcellular Localization:
Host cytoplasm.
Sequence:
MKFFLKDGETSRALSRSESLLRRVKELGTNSQQSEISECVDEFNELASFNHLLVTVEHREWMEQHPNQSSKLRVPSRIGEMLKEIRAFLKVRVVTPMHKETASDTLNAFLEEYCRITGLAREDALREKMRKVKSVVLFHHSELLKFEVTENMFSYTELLKLNLSLRVISSQILGMAI
The following text describes a protein:
Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MAHAGGTGYDNREIVMKYIHYKLSQRGYEWDAGDAGAAPPGAAPAPGILSSQPGRTPAPSRTSPPPPPAAAAGPAPSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDSIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKALLSLALVGACITLGAYLGHK
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion.
Sequence:
MPRIPTVELSRYLLTGHIASPGCLRARAALPGKNTRVALGGAPLPSRQLQPRQHARYLTTETSFANPSATTSSPAAAAPFRKQLKEQAKALKKSGHKKKKSSDNQTVPGWELTVGIEIHAQLNTAHKLFSPATTSFNDPPNTHVAPFDLALPGSQPLFQPATLIPAVRAALALNCSIQPVSRFDRKHYFHWDQPSGYQITQFYEPFAKDGFITLYARDGIAAEDGEEIKVGIKQVQMEQDTAKTTAQPGDVQWLDFNRVGVPLIEIITLPEIHHPATAAALVRKVQMVLASVDACVSGLEEGGLRADVNVSVRRTDDPSGKLGTRTEIKNLSSFKAVEDAIIAERDRQIELLEEGGEVKGETRGWSLGSTETRRLRGKEGEVDYRYMPDPDLGPVVIGEDLVARLRETMGVLPDQEADQLMERYNLSAKDALSLMLLDGGARIQYFYNVLDSLEERLVADGQAVPEGAEHATLAANWCLHELGKLTDSASSSSCSDPDVLEGLAMTPLGESPLVPSSSLAAILHHLYSRTITAKVAKDLLWAVYRGEIPEGGTTSYIDTHGLWFKELPEEEYAKLADEVIQGEEKILGEFLRWKQGKMKAYPQGKLMFLVGKMMRGGPEGRVEASGAERVLRRRIEEVYLPELEKGE
The following text describes a protein:
Function:
Involved in cytokinin-mediated development. Together with SOFL2, triggers the endogenous content of specific bioactive cytokinins derived from the biosynthetic intermediates trans-zeatin riboside monophosphate (tZRMP) and N(6)-(Delta(2)-isopentenyl)adenosine monophosphate (iPRMP) such as N-glucosides trans-zeatin 7-glucoside (tZ7G), cis-zeatin 7-glucoside (cZ7G) and N(6)-(Delta(2)-isopentenyl)adenine 7-glucoside (iP7G).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Domains SOFL-A and SOFL-B are required for function in cytokinin-mediated development.
Sequence:
MESPRIHGGAEEKSSCESGWTMYIEDTFHGNHHSEVVYEEEDDGFSVKEVDDDGDGDEDDDDDDDDDSSNNESDDSMTSDASSWPSTHQPPRSTKNHAAAKNSNAKQVNNQTENRVRDRFSDEGEESELKARTRTTAASRVKVSKTK
The following text describes a protein:
Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
Sequence:
MSATTACPKTRAFQLRVNPLTGDSEWIVVEEGGDREELEEKTSENLLATTSYLDMLNDSYRNWAFRAAIEKSIKKPCHVVDIGAGTGLLSMMAASTMAKFEEASEAKVSACESYLPMGKLMRKVLWENQMEKKVKVFHKRSDELLVGVDLQSPAEVLVSEILDSELLGEGLIPTLQQAHDMLLAKNPQTVPYRATTYGQLVESPFLWKLHDLFSNEINLSDGIHLTPAGLERVIGIKKQQYAMHCTAMSREIRLLSEPFKIFEFDFWKKPESHGEIEMSIKASGDGNVIAVISWWVLQLDEEGSIFYSTAPRWTNCPDNGMVENCIPGNENWCDHWKQCVWFISGAGLPVSKDKLVLFKAAYDEIKISYHLKCDDQTCCNNFNFGNCLLELSPERVAVYGDKDWRSGFINAMRNTLNVRSAPLCIVADDSVFLTILISSLSKNANTISSFPGIQEKGAQYLRAVADSNGFSMDRVKVIGKRASYLFTDNLIQQKVDFLVGEPFYYGNEGALPWQNLRFWKERTLLDSILSEDAVIMPCKGILKVCAMSLPDLWRSRCSLKKVEGFDHSVVNKTLGACGDLPPMLEGPCLPYYIWQCGEVEELSEILPLVEFNFLEPIHACSGKIKIEFSKLGICHGFALWIDWVLDNKKTLVVSTGPISRYWKQGVKLLSKPLAVNAADSFAGIEAFFDHSSGEISISSFSPS
The following text describes a protein:
Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MASGNRSSLFVGLSAVFYLVLLFSPLAFLQTANAQSDQDPLQESYGTVIGIDLGTTYSCVGVMQKGKVEILVNDQGHRITPSYVAFTDEERLVGDAAKNQAAANPKNTVFDIKRMIGRKFNDKDVQGDMKHFPFDVVQKDGKPSVQVDYQGTKKTFTPEEISAMILGKMKEVAESYLGKTVTHAVVTVPAYFNDNQRQATKDAGIIAGLNVLRIVNEPTAAAIAYGLDKTEGERQIIVYDLGGGTFDVSLLSIDRGVFEVLSTAGDTHLGGEDFDQRVINYFAKKYNKENSVDITKDLKTMGKLKREAEKAKRTLSSQKTTRIEIEAFHNGNDFSETLTRAKFEELNMDLFKKTLKPVEQVLKDAKVKKAEVDDIVLVGGSTRIPKVQELIEEYFGGKKASKGINPDEAVAFGAAVQGGVLSGEEGTEEIVLMDVNPLTLGIETTGGVMTKLIPRNTVIPTRKSQIFSTAADNQPVVLIQVFEGERTMTKDNNNLGKFELTGIPPAPRGVPQIEVSFELDANGILKVTAGDKGTGKSESITITNDKGRLTQEEIDRMVQEAEKYADEDKATKERIEARNGLENYAFSLKNQVNDDEGLGGKLDDDDKETILDAVKEATEWLEENAATANAEDFEEQKEKLSNVAYPITSKLYSGGPGGDDEPEGHDEL
The following text describes a protein:
Function:
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MKMRLHFVVDPMGWFCMSMVFFVWIYNSFLIPKLVLLPHYAEGHITAEPVICYYLASLLCFSALFRASTTDPGKLAQDPKIPLAERDNWELCNKCNMMRPKRSHHCSRCGHCVRRMDHHCPWINNCVGEDNHWLFLQLCFYTQVLSFYTLVLDFCQYYYFLPLSSVDQADFAVHHELALLRVSCFMGLIMFGGISSLFYTQVKGILTDTTTIEKMSHLTEEVPRRPWQQAMAEVFGTRWKVLWFLPFRSRHPLKLNLTIRSHV
The following text describes a protein:
Function:
Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
Sequence:
MGLLSLGSPLSWEETKKWADHVRKHGIQQLINIYRRLKDRHGDVLKWGDEVEYMLVVLDENNRTARLSLKGNQVLEQLEKRERESPNDPPTTWRPEYASYMIEGTPGKPYGGLMGHFNMVESNMRLRREELLSLLDRELGETAISFTVFPRLGSPAFTDPQVECNPTVNTASRSLFFPDAAINHHPRFRTLTRNIRERRGEKVCINIPVFQDKNTPKPFRETFSNGDEESRKAAKDDHIYMDCMGFGMGCSCLQMTFQACNIDEARHLYDQLAPLCPIFLALSAAAPVYRGYLADVDCRWNIIAGSVDCRTREERGLEPLKDDKFVIPKSRYDSIDCYLTPEAQKYNDIDLVLDQDICQQLEDAGIDRLLARHFAHLFIRDPISLFSEKIHLNDDEESDHFENIQSTNWQSMRFKPPPPNSPIGWRVEFRPTEVQLTDFENAAYVVFIVLLTRVILSYNLNFLIPISKVDENMQEAQKRDAVRQGLFWFRKEVLPPNECCEEDPKPKPAAKSYSQYNGSCQQEEYTKMSINEIINGQAGGFQGLVSLMNSYLETVEIDVDTRCSVQQYLRLIQKRASGELMTTARWIRAFVQNHPKYKYDSVVSDEIAYDLTKVSDEITKGIRSCPELFGMLNSRTKVSLPPVVHKKLRKENPDHDILT
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MILRGMEDSKSAQKRFEAAVKVIRSLPEDGSYDLSDDMLVLFYSYYKQATEGPCNTLKPNSWDPIGKAKWEAWKDLGNMSKDQAMTEYVQEIQLIIETLPVTDRMAELLDALDPFYEIVEDDDDDDDEGVSKAAPLFTGSTNADKDAERDEEVESESKEGNLDDYMELVEKQKDLSSTTGEKGSLLVFNRSEENSISSLTDGTHSSLNTVDDEEELVYDGSDDEMDSDSMDKPATPEKGSGVRSVRLADGSVVGANMQHGGNREPQCGSQDGKPQGLISPVPHPPTLGTVRNDRISACSGRERGCQGDGGQRGETADRMDKQAINTQITTILSELEDNMQDVLRRLTTLEQLTASQAEISPSKTWHSDKPKKRLSWWPLNSSPFTAVLTVLWPFAVHWLVQFYLQRRRRR
The following text describes a protein:
Function:
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.
Subcellular Localization:
Cytoplasm.
Sequence:
MPCLLATNFPIVPDDKQIKTEEFLEACSKIPSIFDLLGGKVFYPVKNDVVGNIKKIQDRFLQNPIKFATLNQIIEEEKLETDKALKAKDGGGIATNALMWLKRGLLFIILFMEHLLKKDYGEDMESLKECAKLAYKDSLQSYHGWIVQKLVQAATSACPYRSDFLKKFSEGEGLSVDEVLVRLEEYIVNFRANVDVIYDLFETTGAEKTHKV
The following text describes a protein:
Function:
Functions in nuclear protein import via a substrate-importin alpha-beta transport complex that passes though the nuclear pore complexes (NPC). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus envelope.
Domain:
The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
Sequence:
MSSRDKQDSRKKEFKKSLDSETARRKREENSIGIRKNAREELMLKRRGIVQPNPSTSYQIIVPPEVQEQFQKYENETMENKIKNLPGLVTALNSNDQAYVYSSLVQFRKLLSIHAYPPIDQVIECGIIPKLNQLLQCNNPKVQFESAWALTNIASGNNRQTQTVMESGSVPIFIQLLCAETTDEVKEQCAWALGNIAGDTVDSRNYLLKYGAMNALIPLLHYGEDNGATTTSANSERKIGLIQNVVWTISNLCRGKPQPDFSVVSQCLPAINELIRIENLPSEIYGDLCWALSYLCDGPNTKIQAVIDSGVVPRLVKLLEYPDSIVFTPALRAVGNIVTGESSQTQIVIDNNGVELITRLLAVQKKSIRKESCWALSNITAGEPSQIDVVVSNPKTVTTLISLLSHSEHDIKREACWALSNSTNNSSTKSIQTLVRHNILKHFIDLLNSQDLVILKIVLEGLINIIKEGEKTKTKTGVNPYVNLISEMQGESIIYDLQEHQSKDVYKKAFELIEFFESSDYSDSENSEPNINQNGQYEFSSNYNSNSINI
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MCFDNLLAKRMVPVWMWKEGQPKRHLLTTGWSVFVSAKRLVAGDSVLFIWNDKNQLLLGIRRAIRPQTVMPSSVLSSDSMHIGLLAAAAHAAATNSCFTVFFNPRASPSEFVIPLSKYIKAVYHTRVSVGMRFRMLFETEESSVRRYMGTITGIGDLDPVRWANSHWRSVKVGWDESTAGERQPRVSLWEIEPLTTFPMYPSLFPLRLKRPLYPGTSSYQDSNNEAINRMTWLRGNTSELGPHSMNLQSFGMLPWMQQRVDSRIIPNDINQHYQAMLATGLQSFGSGDLLKQQLVQFQQPAQYLQHASTDNSILHQQQIMLQAVHQHMQPAQTQMLSENLQRQSQQQSNNQLEEQAHQHAYQEAFQIPHNQLQQRPSSNVSSQFLKADFADLNSKFSASVAPSGVQNMLGSLCSEGSSNSLNINRTGQCVIMEQPPQQSWMSKFAESQLNTCSNSSPLPTYEKDTSNPRENCSLDSQNQVLFVANVDSSGHLLPTRVSNVTTTCADMSAMPLGASGYQNSLYGYAQDSSELLHNAGQIDPPNATHTFVKVYKSGCVGRSLDITQFHSYHELRRELGQMFGIEGFLEDPQRSGWQLVFVDRENDILLLGDDPWEAFVNNVWYIKILSPEDVQKLGKEEAESLNRGAVERMSSSSVDDRDLISGMPSLGSLEY
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPMPVRSLLTRAGAARMNLDRTEVLFQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGSEKQHDCDYKILPDLGVKHSENDSVPMQDTQVLPDIETLIGVQNPSLLKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQLEELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWPEPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGVAQLSQAGPSKSDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFENKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTDHVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTANHNNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQPKTPDNIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQLSEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNGQTTTLSNSHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDATHTQIEEDVATQLTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKSTPSRDRRKKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEEKVKVEPLDSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIRFQQVVKEQLMHQRLPTLPGISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSSSFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVIQKDKGPYYTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSDEEKVLCLVRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLKSYNGHPTDRRCTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPCRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKASSLPTLGSKTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASAPPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV
The following text describes a protein:
Function:
Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein.
Sequence:
MAHYQWRKFQFFNDGTPQGDLPAELQKPLRCSSCDRSYLFFGGADGTVVVTDRSLKVVANFPAHGHTVSQMQQLKQRNMLVTVGEDEPPPAGKVGVSVVKLWDMDKLAGEGGGAGGGPPCLKTIKVFTSKFPEAEIASFLVLEEAPPSLWAIIGLNNGQVYLLHGDFGRDRIVRTRLVVDPGEDDWPPSRVTGLTAASQGGTLYLFAATLDVFVSFNLAQSAPQRRQLDAHGCQPHCLTMSDANEPVLGRPEAVYFYEADGRGPCWAFEGEKRFLSWFRGYLLCVTAEPRNPLKNVVTVYDLKNKLIAYNATVGGVQHVLSGGGMITILTDDHKALCLAEKDMGSKLEMLFRKNLYTIAINLIQGQQADAASTADVMRKYGDHLYGKQDYDEAMAQYIRTIGQLEPSYVIQKFLDAQRIHNLTHYLEKLHEQGRATADHTTLLLNCYTKLKDVAKLDEFIKAEGDHRFDVETAVRVCRAAGYYEHALWVAKRAGEHEWYLKILLEDLGRYEEALKYVGALATFEAAVTLKQYGKILVTHRPGETTAILLKLCTQGLAPARDTSNRPPAPNGVSSATARGDPPTASPEASTSKSSTRGTAPSEASTSKPSARGIIRGAEEEMEPILPSPMDFVHVFVDRPRWLLRFFEQYSEQVKGSPSEVPINNTLLELYLADDLQATAIAKAALSGPVPVPSSLETEEAERERKERLKKALALLKAGWPPHEPQPKYDPDLAVVLCQMHGFREGRLFLYEKMRLYKEVIASYMADSDHAGLIACCRRLGTASRGGDPNLWTDVLTYFGEKGGPDCEKEVREVLEVVERDRLLPPLIVLQKLALNPHLQLATVRDYVARQIAQDTRAIEEDRRAIEKYKEETAAMRAEVAELRSAARIFQNTKCTACTSALDLPAIHFLCMHSFHQRCLGENEKECPVCAPANRTVLEMKKSLDQNSNDHDRFFQLVQNSDDGFSVIAEYFGRGILNRHPAPQSSMQQSSTRTLSQIPDLGQLVLS