lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex, dcaf1 may function as the substrate recognition module within this complex.
Subcellular Localization:
Nucleus.
Domain:
The DWD boxes are required for interaction with ddb1.
Sequence:
MTSKEIYPLRSTGTMMMISDQDLKLSTQLMLRIAELLLEFDANHEQSSFDPIPILKRISELLEQATDIFIKNDPDPLDDRHPHRTHPDSALGNILKIIFKNDDFMTKLVVSYILARDNVELNIQGSRLLLACIPGLDSKVVFSEPDDFIPRLYTWAGSEGTNETLQGYAMGLLAAALENTENASKYRNENALLVPFGLRRLHELQGRSLEEQKKIGQTDFSQLHAEQSTSNGTSIPSIKITSVDGSTKENEKTFVQSTDPPPPKKRRTEPCLTSLLRTEITQRVPSFHNLRNLDDSNSKWDILQPFLIGDQQVYPLSLATYQRFILQYLAACGEYQDLLLQTFEGNALEILFDYIDLEKSKDVRLTFDALKYLTSLLVHRKFALEFVNKGGIPALLKVPKTSLASVGVVTCLYYIAYSNDVMEILCQMSDEIVDETVQYVLWCLEHSHESGMASACMFFSQGLFYKAILRRFDQYDGPRKLHNYIATLTLMQNNEDVELTEEQIHTSTQCTRGVCTTFRSYLTAHIFIKVENYKKLYGNNLPTGMRFPELVQGDCPDYKSMKPYEEVCWQCEAIVTEMLRFTGSSFREAENLRKLGMVRMFLAVRVLSRDWENISPSLRTEMCVHALETLCMMFCLPSIQTELITQHSYNHSNYDGFTILLQTSLGRYDEDPSLRMAALGCIQRCVYVEPECWKAIIQRVKSSEEKSSSASKRQSKYEIIMNHLERMWTEVRKTDGIMALVNLINCKIPLTEADSIRKTATNTLTGLARHPEVRQILAKLPLIAHNGLQNLMREPVCSDKRDIHAAFCKEAVQLLQVIYGRKIHDQQGKEIQSSEKSHRQWVIENTQVSFNQAELLQLIHDHLLKSKLDSVAAMLKSEAKLPDRPASRSINTPILNKPLPSSGNNFSKINDTYPTLAPRTLESEIGGISARRPSNAASLSSPAMATRSHSTDDDVFATPTLPRRYTTSGAFPKKLMISPARQKLRPLTPGESSSGYRPIKDLNSIVTDYFRNQHSTCKNPVTTCPPFSLFYQHKCPELSYQTNVVRNISLRTLDQELLRPHERVYSQWTNERTIFSRFRNWKTIHDHDESYTKATFSVDDEHLIVGLFNGEVHWINVDTGLDEGHTNCHGSALTNIEPSKDGSMMLTSSAFSRPLSALWRLGEALQRVHTYREDSCVKFANTTMQRIVGTCRDKATVYDTETNHVLDTYLSGIDGLQYEKNYASFSPDDKLIFNDGLLWDVRKKNSAIHVFDRLSKITLFGTFHPHGTQIVINSEVYDIRTFRMLHHVPELNRCQVSFNSTGNIMYATEVTDVHCPDYDEKIFSSFRTFETRDYSALTTFEGRRPVIDLCASHQDQKMCVIEKVRPQMSDYMIQASTQLKIVEIGRLKDNEDENDEEEDEQREDHDEDEDSDESGDGDDDEEIGGNSSDRESVFRTLGRLGDESDSGSSVDDNDTLDDLDFENAQNRIIRRQAQRRRQRLNSSENDAELPGSDEGSDEDGDDDEDGEGDPDFDMGAAIDDLVDAVDEEVDEDELGTDGDDDDSGSWRTTNSIDSEDINLDDLDEEEARVVENEGNNERPARPVDPIEAAAAARRAILGRGLRDLRMGIRGGNRRRNGGGLEQAEMLNARAEEQRVSFMEALVRGAEAERREEEGGDDGESSSSSSSDTDEYQSEEEEINSVSTTALNPALRRRNRRPDDEA
The following text describes a protein:
Function:
Elicitor of plant defense.
Sequence:
MERGVSYYLWIPFKFIHQTFGSLLLKLLGLRSPSDHSFPEDGEEEVKVVEVSSRGLPGKKNVLKKSRESSGKPGGTNKKPF
The following text describes a protein:
Function:
Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA; Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MNWHCNFGRIPKAEFLPECFYNSFVLHLNKRCCSNKYSTFDCFCLLDCAHLSIGRACAEACSSVNMAATQGTNPSQLLPLELVDKCIGSRIHIVMKTDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLIPGGEGPDV
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of malate to oxaloacetate.
Sequence:
MRMKKTVAVIGAGNVGEHVASLILLKNLANVKMFDLPRKTEEKVFEPVKGKALDMKQMLAAMDIDARVEGYTVTPEGEGYEPLEGSDIVVITAGFPRRPGMSREDLLEANIRIISVIADRIKRYAPDAIVIVVTNPVDVMTYVAYKLLNFPKNRVMGMAGVLDSARFKTFISEELMVSPKDIHAYVIGGHGDEMVPLISISNVGGIPLKDLLPKEKLEKIIERTRFGGGEIVNLMGTSAYYAPAAAIVDMIEALVQNSKRILPCSVYLDGEAGEYYGVQGFCVGVPVKLGSNGVEEIIKVPMIEEEREMWRRSVESVKKTVEVAEGILSAGSSRQ
The following text describes a protein:
Function:
E3 UFM1-protein ligase that mediates ufmylation of target proteins.
Sequence:
MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLEREIQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEKLVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGALAAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQVTSKQANSQYVPHIYAKTQADWVNSFYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYLDLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQALAESQAKAAIDGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSGKAGGGAQGRETKTKSTKKHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKPLELVKTADIVKLITASLEEEGLEHLSKSIASLYTNQFNQTALARAQELFEATPQTNRRQTHAAIQDRINTLLIDIRLYEKGLKLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKNTNLNVDQRNKLAQECEAQYRAALLEQNKALNKSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQKQLLECNEPALLLHLAALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVLQAIPDSNESKLANEHLQTMQNQVVELAQNFSRASISKAD
The following text describes a protein:
Function:
Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity).
Sequence:
MLPILLSFEGKKVAVFGCGSVGKRRAKKILKSGGIVDIYSKEFDEEIKKLKESNKNLNLIEIDINQLSDEELKNIIMKYDFIVTAINDEINKRIVKLAKELNKFVNSSTKTEGVNFIIPAYTEVDEVIFSIYTKGKSPLIAKHIRIFVENYLKSTDINMIAYIREFLKETIPKQKDREKILKKIFENEKFREELKKLIEKWENGNH
The following text describes a protein:
Function:
Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes.
Subcellular Localization:
Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
Sequence:
MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRDMQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which seems to be clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. It also function in maintaining the identity of lytic vacuoles and in regulating the transition between storage and lytic vacuoles.
Subcellular Localization:
Endomembrane system. Golgi apparatus.
Sequence:
MESFFQNTLTDLVKALRSTSLGEAAFLEAALADCKREIRSTDPHIKATALQKVTYIAMLQGSGMEWASFHCLEVMSQARFWHKQAGYLALCHSFTGHSDLLLLATNLFKKDLASQNEYEAAQALNALSRVLTPSLARDLLPDVCRALLSGRLAVRKRAVLVLHHFFRADPDTAPHSAFKALVDSLNDSETSVVCCAVNVLCELVCSSSAPSAYLPLAPPLFALLTRSSHTWLVIKLVKLFAVLAPLEPRLAARLAAPLTAILERTPAKSLAYECVRTATASLPHHPEVMALCGDKLREFIQDEDANLRYLGLLALERLLPGQAAVVAPHHGTALACLSDADPTIQAVALRLVRALVATPDDAALVSEALLRLVRGGAVEPDFQFQLMAALLDLNSRDHYALVADFAWYVSVLVELAAVPGSPHGGAVAAQLEDLALRVPDCRPDLVHHARDLLLAPSLLRGGPAHPTVSAALGAAAWITGEYAEHVRDPRGVLEALLQPNVTALPAGVQAVIVQAILKLLLHARAASSGGAASAAANAAPTVVWAPLPSTSALRAIPPEQEDAAGNPAEGGGTPDELSGAEEALPTSSNQADRAGPAAAPQLTGQDGSSDVGCPDRRGTPESSEPHVGEAPPSLAGSLEQLVRAHLGPLLESGHSAVQERAGNVAALLYLAATPTARGALHRLAAAQKEELRPVAPHAQAMVEVPPGLPLDTSLAGLAGLRAEYGMPGPPEWGPEARAREDAAAERPQTVDEGQASEDARAARAAHRQRHGQHYLANDERAPEQDTGQEKAAGATQQAPAPAPKRKPARAIVKLDEDLPPGVVRWRSGEGLPSAGSLKGGVLDQSVASLLAGKHGSAGEEVQQEKRSRSHRSKHRGSQRGPGSGGTELGSEQLGKERTGGRRQHKHHSRRSAPANAQEKEGPSLASGTGHDLPPLISFEHLSRPVT
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQYLELCRRIVSEGEWVANERTGKHCLTVINADLEYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRALGTKTWDANANENAAWLANPHRRGVDDMGRVYGVQGRAWRKPNGETIDQLRKIVNNLTKGIDDRGEILTFFNPGEFDLGCLRPCMHTHTFSLVGDTLHLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIVNAHIYEDQLELMRDVQLKREPFPLPKLEINPDIKTLEDLETWVTMDDFKVVGYQSHEPIKYPFSV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MSSSTSPLPSNTSEYVRATRSSCASASTALGLTPNVAAIDAFLTSLDQARFSRLCTQHGLSFPLRFPTPTAEVNFLSIVALLNALSGYRTAFHTATGCGAYQNVVRLMIGLYISSADEDRVVGAGTLTAKGMVGLTEARIVELLGVSVHQERQHETLAGVTVGVRGGEMFEAVQLILNAMHGVGRKLEQLNSPSLGAYIVSLLTHAKSENMDDVQATDYLTCNIAQTFPEFRDTHHISALNQDVFLFKRIFFLLHSLRCKFADKLEWCVPDTKLTLPMFVDNVLPTMCVWFNMFNLADQLPNGMERLYDWVRTKHCNADLPRQGLVTGSKQAGPRLSQDETYAIRAATLNLGAAIVQRAKQLAEQCDANRWLQTLNEVDLDAYLWSVAKDDEALRSVPRLVYACIHF
The following text describes a protein:
Function:
May be involved in autophagy-related processes.
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Endoplasmic reticulum. Golgi apparatus. Membrane; Lipid-anchor.
Sequence:
MTKTKIDLKVVLLGYASVGKTCIVTRYTSGQFGDTHTTIGGAFSSKRVVVGETEVLLGIWDTAGTERYQAVNVSYYRRANAAIVCYDLTNRESWEKVTFWAEELTQNEPEIEIYIVGTKLDLIQQGDIKAVPEEEVKQTARRYKAHIFETSSRTGENVSLLFQTIAEDFCKRTNNGTNPVNSNPSNVVNVNTQTQKKKGGCC
The following text describes a protein:
Function:
Adhesion G protein-coupled receptor. In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis. Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation. In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump. As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKSPRRTTLCFMLIVIYFSQATLNLNLESIVHPLILHEHELTEKEPLREKRAVASSSPVPAEYTVDVEISFENASFLEPIKAYVNSLSFPIPGNSTDLATNILSIEVTTVCRPAGNEIWCSCETGYRWPQEKCLHNPTCQEHDSSLAGHRCSCLKGLPPKGPFCQLQGDVTLRMSVRLNVGFQEDLKNSSSALYRSYKTDLETAFWKGYSTLPGFKLVTVTGFRPGSVVVTYEVKTTTPSPQLMHKANEQVMQNLNQTYRMDYSSFQAVTSNETKFTIIPEIIFEGDTVNMMCETDVLSSNVSWHHVERHSDIQNSSRFSVYTTVLNNMTSVSRLTIYNITQRDAGEYICKLTLDIFEYESRKKIDVTPIRILATEEMKVTCDNNPISLNCCSEINANWSTIEWKQEGKINIPGNPETDLESSCSRYTLKADGTQCPSGSAGTTGIFVCEFISTYGARGSKSIEVTFISVGDNSSHKGEVHEILRHDTEMSTVQSTTGNSLETSKAQEQQANLTITPDPISVSEGQNFSIKCISDVSNYDEVYWNTSAGIKIYQKFYTTRRFSDGAESVLTVKTVTREWNGTYHCIFRYKNSYSVVMKDVTVYPLPLEPNIMVDPLEATVPCKGSHHFRCCIDEDENYRVTFQVDSLSFPAEKEVNGKQVCYKYKFMARTSVSWCLKKLDIFCHFTNAANNSVRSPSMKLNVVPGKNIMCRDPVIGVGEPGKVIQKLCHFSKVPNISGGPTGGIITYKCVGSQWEVKKNDCISAPINSLLQLAKALTKSPTQDKKLPTYLKDLSISTGKVKHEVSSFPGSLGAIVNILDLLSTVTTQVNSEMMMNVLSTVNTVLSKPMLSTWKVSQQQQTNQSSQLLDSVERFSRALQTEDSTFLSINQTNVQMRSMVIKTGHPKTYKQSFVFSDLDLWGNVAIDKCEVGSLQQDSSIVTVAFPTLQTILTQDVQGKNFANSLVMTTTVSHNITMPFRISMTFKNINPSGGVPQCVYWNFNLANHTGGWDSSGCYVHNVDGDSVSCICDHLTSFSILMSPDSPYPGSLLGILLDIISYIGLCFSILSLAACLVVEAVVWKSVTKNRTSYMRHTCIVNIAASLLVADIWFIVAAAIHDHFYPLNETACVAATFFIHFFYLSVFFWMLTLGLMLFYRLVFILHDTSKSIQKTIAFSLGYGCPLVISVITVGATQPQEVYTRKNACWLNWEDTKALLAFVIPALIIVVVNMTITVVVISKILRPSIGDKPSKQEKSSLFQISKSIGVLTPLLGLTWGFGLATVFQGSNAVFHIIFTLLNAFQGLFILLFGCLWDQKVQEALLKKFSLSRWSSQHSKSTSLGSSTPVFSMSSPISRRFNNLFGKTAAPKGPPGNDGNLVSSGSSPI
The following text describes a protein:
Function:
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSDISEEYEEEDQGPNLGEYDGERNDDGERHGFGKAILPNGDTYEGYYEHGKRFGQGTYRFKSGARYVGEYYQGKKHGQGIFWYPDGSRYEGNWVNDQRHGSGTYFYANNDLYEGNWLNHQRHGQGVYTYADTGTKYKGSWENGKRQGFGELIHANHSYQGNFTSDQPEGKGKYIFDIGCEQHGNYELVEISQGGINEDDEPVKIVVPTWRSGKVKARNVINDDEVEDILKLDSTNNSRPESAVIAGNGENNQPVEAKDEETVNNETNDDNTNISENQEGSVVPDVVAGESEAPPTLAVETPVAET
The following text describes a protein:
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Sequence:
MKQKEIKQKDNLDQQEKPVAKKIKKNEANPAEEYEVVETMLTADFYKAGVVELAQKLIGKIIVRQLPQGEVRAIIVETEAYKAPEDKACHAYNNKKTDRTKYFWQDGGHLYVYSIYGNNYCLNITAATKDDPEAVLIRAVQPLSFDIIKEIRKTKSTKVQDLSNGPGKCGGCLLLDKSHNGLNLCDQKSGMYLIDNKKQYEIGVSARINIDYAEEWKDKPWRFYVKNNSFVSKG
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MQVLRPSFVGNKKVISFNEPRCTPKVDSMPRSLSAADIDTALKQADKDPSLIGNFSKKCALPLVEGAAHDLKMITPSTLADLIQGKYQSVVDNYTVIDCRYPFEYLGGHVQGAVNVFEPQDLLGAFLDETCLSSSHTRHVLVFHCEFSSERAPKLARLLRHEDRQLHMDVYPELRHPEVYLLQGGYKAFYELFEDLCEPCGYVPMRHKDYEAHLCVYRGQAKSTAKRRKARHVRTALCTPSSQHKETLQ
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Sequence:
MAGWRTVVVNTHSKLSYKNNHLIFKDAYKTELIHLSEIDILLLETTDIVLSTMLVKRLVDENVLVIFCDDKRLPTAMLMPFYGRHDSSLQLGKQMSWSETVKSQVWTTIIAQKILNQSCYLGACSYFEKSQSIMDLYHGLENFDPSNREGHAARIYFNTLFGNDFSRDLEHPINAGLDYGYTLLLSMFAREVVVSGCMTQFGLKHANQFNQFNFASDIMEPFRPLVDKIVYENRNQPFPKIKRELFTLFSDTFSYNGKEMYLTNIISDYTKKVVKALNNEGKGVPEFRI
The following text describes a protein:
Function:
Transcription factor (By similarity). Coordinates the placement and migration of various organs during embryogenesis, including the salivary glands, hemocytes, germ cells and Malpighian tubules. Likely acts non-cell-autonomously to provide signaling cues from the mesoderm/musculature to nearby tissues. Mediates salivary gland positioning, at least in part, through activation of the secreted signal Sema2a.
Subcellular Localization:
Nucleus.
Sequence:
MLPSCYANGSMLPDNEELVNSMLANPDYLRTQVSPNPLAPSAVGGAGMEGLMCGSFSPAFYYQGIDSFLALHNNIWGLPISFLHNSHRPEKPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYERESGKDSNDGNSSAAEIRSPSEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELHSPSAFTPPLNRRETSSSGAPVLAEAFNGIKDVVDAPGSSPVASSNRSKTTLFTIDNIIGKP
The following text describes a protein:
Function:
LEA protein are late embryonic proteins abundant in higher plant seed embryos. There are two subsets of LEA proteins (5a and 5b), the first ones are expressed when the cotyledon weight reach 80 mg and the second set are expressed above 100 mg. The function of those proteins is not known.
Miscellaneous:
MISCELLANEOUS: This is a SET 5a protein.
Sequence:
MASSWFFIVFLVLTVASVRCTTVDHMPSTDEDARDYSKLKTKTEEATDEHHSRTQQAKDELKSKADHAANEVKSNTQQAKDRASEVGKEAKEYTESWTEWAKEKISEGLGFKQDDDPKGSVEKAFDSVADTATKTKDKLQDMASGAGEYSAGKAKDMKDTAYKKTDDVKNAAKGKSSEMRQATTEKARELADSAKENANTAYIAAKEKVRDMADRTSEMTNEAQERGARKAEEAKEVVAEKAEGAAEETKKKNEERGESLKWAKEKAKQGYDAAKSKAEETIESAKDTIASGYESRSRNHKN
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASTGKWETVGAKKSKKSTSKSNGKKPGGTGTVERNPVIEHAKPIETAQTIWSSVAELEVDDEHKENKQIQANKDQAKSSNASPKSPKKTGADKKKQQGKDKKAGKREFKTVEDAMKKLDANVLKTVVQDTKLKFPDNPQFWLNDLASMLNLKLDAPDLDPTFYQQPAEYPLSILPKPVYSVLSSTVTSCPLQVQNIFFEHCLYMMVKEMTNGTPTYGYRICIQYLAQSRPEVTTANLPKFADLLKTTVNRPNVCLSIIWGLSQSGSKDLATGLTVWLQLLLPHLGTKSLSSYIIGILENLFKSHKKTKASHNSIGPHEFFPVLDFVFTPNTALAQSLQQRLQAVYPKIKDLALGPSASKTPCQYFPSLLARATPNCPSALKTEIMELLVHCLISDPQSFSNWRQMYTKQLLQSGVLMRYMLDNWDKVSRVLPEKFVQETVLAFSITNEEMAAHTPGREECRSACKELLLKMKKPKFPWGRLIFTILLLVVAILGLDIYTHGSFQASTSHRVLKDSGLLAVSQQAWVKISFYSRKGTDWAREWVPYYYSMVAEVLDPYIKLLWQNLYDLGVWIAEVSAPLRAWLDRKIPLVLEWIDAKVPVVVASVTQVTSKVTMAAQEYWAVLKPHVMVVWTAVGDNIQAVGSWLEKNVFTGKLSPEALQASMVMVWEYVWTSSTAAKQWIVDKFSA
The following text describes a protein:
Function:
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MPSRSSKKRSRPHSPADSGAGNPIKQEPGNSLASLAALVVLATVPFALSIGGELVFDDRKTVVENGVVRGTKPLIEVFSTDYWGDPLASMTSHKSYRPLTTLTFWLNHHLHGLWTPGYHTVNIALHAINTLLVHRLTTVISSKIASGPNASGYGSWAAAAAFAVHPVHVEAVANVSGRAELLSGVFYLAAVLLYLGSVPAIGMVPRNAIYALLVVLSVASKEQGITAPIACVVLEWALGGRRSSMRRIAANASLVAGIAITINYAHYWMYSLSLLLLPSSLCFDYSMGCFPPILNITDYRILSTVVLIALAVTVLVLLVAAEERSRKRILSASLLTVIPFLPASNLLVTVGFTVAERVLYLPSIGCCLLLPVVVDAIRTRLHQSINKSIKSLGWTALVIAAAISAQRSLEWRSSLVLFTRDLGVCPNNAKIHYNLGKVLADAGSLQEAEARYREALRLHPAYESALNNLGNLLEARGKTSDAEEYLKQAIRVAPSFAAAWMNLGIAQMRAGKYNMSEASLTHSIALRPGSAEAHFNLGVLQLRVGRQEAARASWLHAISLDSAHSLAWSNLLVLLDEMNRCDEVIDLSASALAHNADLASLRLSIGTCYAKRGDFIEAERELRRAVQLSPSTAIYHANLGVLYQRWHRYEDALRTYSTALDLDPTVTSIRENLETTRRRLNQTRN
The following text describes a protein:
Function:
Acetylates the N-terminal alanine of ribosomal protein bS18.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKKLEINDTDYIDQIFNLEKEIFKNSAFNRTYLDTLIKGDNSFIYVYLIDSKVCGYLIVLDSIDIYEILAIATIEECRNKDIAQELLNKIKTKDIFLEVRESNQPAINFYKKNKFKEISIRKNYYSKPNENAIIMKLEVNNE
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSTCCNSELTVPTHTSGTNCTVAMGPSATITMGAKPKLPRQGVAGVPPPSGQLLPIDLTSPVKKLSKSGVINAYRDACTEVQCLSSCFNSTYNCIGSFIDIAQMVCAAKTVQRPALARLMSRLRRRWPRSSYGSGIAKIPPVSAWYYNPNSEEDSEENDPTLPHHFNPDQHVTQEHLQSLGVLVWTGLQTSNYTKNPLFNLVKSDRGYHYEEVVTVAPGSLPDYDLKKKEFFNEHLHEHEEVRLILEGGGYEDVRDFEGRWIRIHITKGVLIELPRGMYHRFTLDDTNYLKAVLLYQENPIRIQFDRNDGTDIMEVRLRYKANILNRDTSLKLTSSDLNSMLEGLDDEVEMIRARQDMVDATLSEADLCAGSVATQKQTQCGPEVVKDCMDPYEADSMELDSVNLKHHMTVVQ
The following text describes a protein:
Function:
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
Sequence:
MDARAINSREKADLKYPRNTYIIGDVQGCYRELQELLELIQFDSTKDRLGFVGDLVNRGPNSLEVLRFLKSLSSPLIVLGNHDLYLLILGYGLMPEDSYEHTLHAVLQAPDKLELLEWLRHSPLIRYEKSLSAVLVHAGLPPQWNIKESILHAEEISTALKGPHYLAFLKNLFGNEPSQWKEDLEGQDRLRYICNAFTRMRFCDAKGHLDLESEGKTNQAPSRFRPWFEWRNPQEDNVDIVFGHWAALNGQSSAPHTHALDTGCAWGYKLTAINLKTKERFSVPCQSALRM
The following text describes a protein:
Function:
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation (By similarity); Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance (By similarity).
Subcellular Localization:
Endoplasmic reticulum lumen. Secreted.
Sequence:
MRLSLLLLLPLLGAWAIPGGFGDEASLTATAPELDDEEKFSTHIPTHLRCDACRAVAYQMWQHLTKAEAKLLPLDSGGRRELSESVYTDVLDQSCSQTWQGYGVGEVDQVKRLMGPGLSTGAQPSIMVMIMEGLWPTRLSKTCFHYLGEFGEDQIYEAHQQGRGTLEALLCGGPRGACSEKAPDTRTEL
The following text describes a protein:
Function:
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Miscellaneous:
MISCELLANEOUS: In contrast to the mouse or rabbit ortholog, the IMPACT locus is not imprinted in Xenopus.
Subcellular Localization:
Cytoplasm.
Sequence:
MADTEEENVQRQIDEVEALTSIYGDEWCVIDEAERIFCITISDSSNKPTWTLCLQVILPPDYPVASPPLYQLNAPWLRGEDRLTLSNCLEEMYLQNLGENILYQWVEKIREFLVEKSQTSDPGPSLKSTSEETDVGDDCEVSTDELTESFKNSMIFGMNYSSGVEEIPPIVHGETISDRRSTFQAHLAPVVSPYQVKLILNKLYENKKIATATHNIYAYRIYIKERNSFIQDCEDDGETAAGKRMLHLMQILDARDVMVVVSRWYGGILLGPDRFKHINNCARNVLMEHNYCSTVEESSKQTSKSKKSSQRK
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MSDEDVQDVDSPETEASPAASEAPAPPPPAPVDPNAPPKPEVDDESPMDWYILKVAFNREDSIAEALRKKVRMEDMGEYFGDIVVPSEDVATFTRDGKRRVSKRKLLPGYIMVYMSINDDTWFLVREVGGISDFTGSAGKPQPMEPEDVERFINRPAVDDEDETPIKTAIPFKVGDRVRVKEGNFENQEGEVDVVDEANGRVTVIINIFGRSVPMELDHWQVEPL
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Binding of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4-bisphosphate occurs at a much lower affinity. Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity).
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus (By similarity).
Sequence:
MGDRERNKKRLLELLQAAGTGNGHCADCGAADPDWASYKLGVFICLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHNGNLSVKAKFEARVPTFYYVPQASDCLVLKEQWIRAKYERQEFMAEKAVSPPGDREGFLWKRGRDNSQFLRRRFVLLSREGLLKYYTKEEGKTPKAIINIKDLNATFQTEKIGHPHGLQITYRKEGQTRNLFVYHDSGKEIVDWFNALRAARLQYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLDAFEQGQVFLGSNEQGYEVWEGLPQGIRGNRWKVGLTVITPERKFVFTCPTEKEQREWLESLRGVLSSPLSPLHLLTTSAKSG