The following text describes a protein:
Function:
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Together with MCU, has a role in oxidative stress-induced ER-mitochondria calcium transfer. May be involved in visual and olfactory transduction, and myoblast proliferation. May be involved in ethanol tolerance.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Sequence:
MGDNIIGSASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICPMNRYSAQKQFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVVGDKVILSPVNADQQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYHVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAMSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLDATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPFQEHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSEDVCLATLAEDPGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKWTGQPTSRSMADLASCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAKFNTTIAFVENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSVEEETNAEAEGGVLRSIGDINTVMTSLALGSVGQAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEPQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCERSDAANLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILRQSVEKSELWVYKAKATDELGATDAGGDAVSLEYNAALSQEQRNEYRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIHGRHVAYLQFLQTVVAAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLGMEKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQLITNPAAASNKTLQAYVLNGVTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELEQQVATMSSKTAMLTRQTTKWLLASKQPKYEAQQAASLMRWDRSIIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMMAIDVNYGEKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNLALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNMNPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKLADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELSSHISLLFWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGLLNTTANSLLPFQ