lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator (By similarity).
Subcellular Localization:
Nucleus.
Domain:
In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).
Sequence:
MEEGSKENCGFNGSPMGSRSPPKQLTSAASVLGEIQIAAANLKTPTKPQERNNADPWTPTANLKMLISAASPEIRNREREILEEQFSGDELEKTLPSRKEKSLGLLCHKFLARYPSYPNPAVNNSICLDEVAGELSVERRRIYDIVNVLESLHMVSRLAKNKYIWHGRLNLSKTFDALKKVGEENRYGEQIQLLRKREQEECDSQNSPNAETQKPLAKQPEVGFVELPGLEFRAASVNSRKEKSLRVMSQRFVMLFLVSDPQIVSLEVAAKILIGEDQLEDLDKSKFKTKIRRLYDIANVLTSLNLIKKVHVTEEKGRKPAFQWTCPELCTDDQENRSSPAALTPVAIDLSSPKENCAKNLFASGGKTFTRHPSLIKLAKSIENDRRKINSAPSSPIKSGDGSSSAASKMAQLAAICKQQLQQSRDQTKVKLKVSACKAKSTVKQPGGSDKNQTPTYCRAIPLLHPHPSAAPPYTVIVQPPQEQTLSRQSPPALGYTNRTPPEAPLQGGRHEGDGTSHSEDHSAQERHPKRLPESDRGCTSKRMKSSAVDDVTETLYPSGYLIPIHLAPVAPEPSKENTGPSSENKLFTSPIPGVFPLKLMFSPGPVTAVPVMSRGGQHVGGGSGSASRSPSPGMFTFALQNRELISAGLPQGATVSPRNGRGQEELSAASVLNCKHVSPVPYHGQPFTVFALQQSAVPVTPKGYHSLQETFFRTPGGMGCSPPESARKLDVGTDD
The following text describes a protein:
Function:
Positive regulator of arginine catabolism. Controls the transcription of the two operons rocABC and rocDEF and probably acts by binding to the corresponding upstream activating sequences.
Sequence:
MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIEDMEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYPIVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRATRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKGAFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDVRIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHLFQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKIKPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQYRLKKFSHSSNE
The following text describes a protein:
Function:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Contractile vacuole. Cytoplasmic vesicle, phagosome. Note=Expressed diffusely throughout the cytoplasm. Accumulates in the cell cortex, contractile vesicle and phagosome.
Sequence:
MSEEPTPVSGNDKQLLNKAWEITQKKTFTAWCNSHLRKLGSSIEQIDTDFTDGIKLAQLLEVISNDPVFKVNKTPKLRIHNIQNVGLCLKHIESHGVKLVGIGAEELVDKNLKMTLGMIWTIILRFAIQDISIEELSAKEALLLWCQRKTEGYDRVKVGNFHTSFQDGLAFCALIHKHRPDLINFDSLNKDDKAGNLQLAFDIAEKELDIPKMLDVSDMLDVVRPDERSVMTYVAQYYHHFSASRKAETAGKQVGKVLDTFMLLEQTKSDYLKRANELVQWINDKQASLESRDFGDSIESVQSFMNAHKEYKKTEKPPKGQEVSELEAIYNSLQTKLRLIKREPFVAPAGLTPNEIDSTWSALEKAEQEHAEALRIELKRQKKIAVLLQKYNRILKKLENWATTKSVYLGSNETGDSITAVQAKLKNLEAFDGECQSLEGQSNSDLLSILAQLTELNYNGVPELTERKDTFFAQQWTGVKSSAETYKNTLLAELERLQKIEDSLVEFAKRAAQLNVWIEAADDHVFDPINVDSVQGVQEIQEKFDAFLHDQSQQFAELEALAALTQQLRELGRSENDYSVISYDELSAKWNNLLAGIEERKVQLANELTTQTNNDVLCQSFSVKANEISDYVRVTLDAISQNTSSDPQEQLNNIRAIITAHAEKKPELDELYTIASQLEEAQVVDNKHTQHSLESIKLKWDKLNTLAKKNEQVVEGEILAKQLTGVTAEELSEFKACFSHFDKDNDNKLNRLEFSSCLKSIGDELTEEQLNQVISKIDTDGNGTISFEEFIDYMVSSRKGTDSVESTKAAFKVMAEDKDFITEAQIRAAISDSKQIDYLLASMPAVEGGFDYNSFAEKLYQ
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Binds to the 5S rRNA independently of L5 and L18. Not required for binding of the 5S rRNA/L5/L18 subcomplex to 23S rRNA.
Sequence:
MFTINAEVRKEQGKGASRRLRAANKFPAIIYGGKEAPLAIELDHDKVMNMQAKAEFYSEVLTIVVDGKEIKVKAQDVQRHPYKPKLQHIDFVRA
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MLHLADLHLGVENYGALDPRRGLHSRLIDYLDRLDEAITIGLDHQIDLCLIAGDVYKNRSPNPTVQREFATRIRRLRDAGVAVVILTGNHDISPAQGRAHSVEIFATLALEGVTVADRPRMHRIETRSGPLQLIAVPWVTRQMLLTRDEMVGASFTTIEYEIRRRLEQFIERSVAQRDPTLPTVLAFHGTVEGAQLGAERAMILGHDLSLPSSVLAQPGIDYVALGHIHRHQVLTRQPPMVYPGSIERVDFGERDEPKGCVLVELAPGQADWRFVPLAARPFVSIERDLRRSSDPVQALQTAIERHNLRDAVVRVEVELTREQAALLREEQVREWLRAADAAVIAAIVFNVERPARQRFAGVAEALDEGLTPLKALELYLKSKQVPPQRITQLLAAAQELMDGVE
The following text describes a protein:
Function:
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MTLDLPRRFPWPTLLSVCIHGAVVAGLLYTSVHQVIELPAPAQPISVTMVTPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKRDVKPVESRPASPFENTAPARLTSSTATAATSKPVTSVASGPRALSRNQPQYPARAQALRIEGQVKVKFDVTPDGRVDNVQILSAKPANMFEREVKNAMRRWRYEPGKPGSGIVVNILFKINGTTEIQ
The following text describes a protein:
Function:
Key transcription factor for sexual development. Activates the transcription of ste11. Binds to a stress response element-like (SRE) region in the ste11 promoter.
Subcellular Localization:
Nucleus.
Sequence:
MTRESLAPIASKANTLSESKVSENLMSINSDSGTSNANTPSSVTSNSKPVASSTAAKKDPNAPPQKVKQYVCETCTRAFARLEHLKRHIRSHTNEKPFTCSEIDGLPTGCGRQFSRRDLLLRHQQKIHRNPQPRRRRRSTTALPNPSLSNVSVSTTNLASKPVISLPQADSIDKFRYPKLHAALQAQLANNSGSFSASWLQAQQQRLVSAGNGRETVNASASGAVNPTSSQWSDQRLGVPYGPDSPLYYRRATIASDLRPSVYQHPQLYDFNRPESLSGQLDDESLARMPYSPNAVSRNYAMNMTLPESIPEGYEIDKLDWMSFSESLNLPTFNQPSGPSDVSASFLNLQAMPSPHASPKDSLINKSNSYFFQNPPKSNSVDYTRLDNLEHMRQSCISPSGTNFSPSCYSPESLMQQPLTLSPSSIPSGLPTYAHVNSPLGTEQYPSEAYPPKGYVDMEGRISEGIKEEGISLSEEITDKDQAFASMGYFDSYNFEGVENSNSLNNEGDQMETNFQSEKLDNSNSIPFFNFNSFNNNGANWSSDFNYPVSETSGLLTDNNRNQPPSF
The following text describes a protein:
Function:
Required for anchoring microtubules to the centrosomes. Required for ciliation.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MSATEEDTELRDLLIQNLENSGVLNKIKAELRAAVFLALEEQDKVENKTPLVNENLKKSLNTKDGRLVAGLITDFLQVFNLDFTLAVFQPEISTLNGLDSREVLSKELGISESEVNKNSPLLLELVKRGRHREKTSIFTEGDRVADRTFPKELLPRQIAEARKKFDSHDKNRSGEINRDAVIGIFADLFPQFSRNMLDCYVTEELRAKGKDTSSTIDFQDFLGMYKCFFIQCRSVVTSDNSDALYSSSKTTEDKIILSSASKAGDRRPGELLGSPKIRGSVQVSEGSEEESGLGDGKNLPTPLKRALEFGLEDEEEEGDSFFDDPLPKPQKTYGCGLSSAEKPYSGQRHSEKSFSQKDLSAIGSDKEGDGEDMLSDCESRPTPDSERRREGLGGSLGKAFTSGTQLKSAGGSISAESSKKDHSSDKNDKGGKDFSTPNEKTGSPLLDDDLDYDDDFNSHRSENSKSEVSIDEEIEEVSIEGPDISDKLDETTQDVSVSQTSLGADYMEDVA
The following text describes a protein:
Function:
Has high NADPH-dependent quinone reductase activity with a preference for quinones with hydrophobic substituents. Also reduces CrO4(2-) and Fe(3+). Somewhat active with NADH. May be involved in response to oxidative stress caused by arsenic.
Sequence:
MTDFNHPPRILFLYGSLRERSYSRLLAEEAGRIITTMGAETKFFDPRELPLRGQVLDSHPKVQELLELSQWSEGQVWSSPEMHGNITGILKNQIDWIPLEIGSIRPTQGRTLAVMQVSGGSQSFNAVNTMRILGRWMRMFTIPNQSSVAKAYQEFHEDGTMKDSPYRDRVVDVMEELYKFTLLLRDKVDYLTDRHSERKAKVNTDG
The following text describes a protein:
Function:
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex hat acts as a global regulator for secondary metabolite gene expression (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Enriched in the nucleus in the dark (By similarity).
Domain:
The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism (By similarity).
Sequence:
MGAQVIAAASNGLCHDDEPIASVKSRITRSGRKLWYSLRVVQEPLRARACGSGPKSSADRRPVDPPPVVELRIFEGESFEMAQERDVTFQYNANFFLYATLEHARVMAQGRLQTPSANTPPVLTGMPVSGMAYLDRPKLAGYFLFPDLSVRHEGRYKLTFNLYEETKEDKDKDPEEPNAPPDGSPGSFDFRMDIKSHDFVVYSAKKFPGLTESTPLSRTVAEQGCRVRIRRDVRMRRRDGKGNSGGNDYENGEEEYRRARRTATPDTAKQEAYRQRSMSGSTERTPYSSISDPQRRPSMADYPPQYAAQTPTSGGHLGFLGGNTHHQYPAQPPPQSFAQPHSVPPSPVYPTSQRAPYQHQPSSYPPPPPPHQPIFQSEHHTSRTYAPINPASRHDSIHQSTKQYTLPPLSEAVSPTQPHHQHPSIAPHRLPVTALPPLQVDRFSSASHNQHPMVSPSNMAAPPYPRAYSVSNSGGLTSAGGYNQLPPPPPPPPQVAGSKRAHDQTFRADPEMRRYQDGARERESVDDKEPPLCTFKYRRADGSVECKQADIGGY
The following text describes a protein:
Function:
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex. Allophycocyanin has a maximum absorption at approximately 650 nanometers.
Subcellular Localization:
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Forms the core of the phycobilisome.
Sequence:
MQDAITAVINSADVQGKYLDGAAMDKLKSYFASGELRVRAASVISANAATIVKEAVAKSLLYSDVTRPGGNMYTTRRYAACIRDLDYYLRYATYAMLAGDASILDERVLNGLKETYNSLGVPISSTVQAIQAIKEVTASLVGADAGKEMGVYLDYICSGLS
The following text describes a protein:
Function:
Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDIDESFFYTFDSEEYNKLWAEVKNSEDPVLYKTCIITPRALITMVDHAIAGDRNEILGFCLGKATKNTILVNDVFSTTTLGTETNCYATTESYVQYFAVKESLELSGRQSANVSGWYHSHPDYGCWLSTTDVIAQNIMQATGPMVALVVDPIKTANTGKVFLGAFRNFPQSYISSQHNFGNSLIPSEKIKDYGASAGKYYQLAINYFLTDSDKLVLNDIIQHSWGEELAESPLIANSIFIAAQINDQAAKRINMLANNVMSGTDIETLKNIVRGINEDRRAGIMIQKMKSEVFG
The following text describes a protein:
Function:
Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 2510 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSFRHFKRRLDTSSADESSSADEEHPDQNVSLTEKSASLSHSDLGGEILNGTGKNRTPNDGQESNESDGSPESDESPESEESSDNSDSSDSDDMRPLPRPLFMKKKANNLQKATKIDQPWNAQDDARVLQTKKENMIKNIDKANQVAKNYETMKLRLNTNYSTNEELIKQCLLLDDNDEVDSEKERQKWFERQNERKQKHRRIQLAKQRESEEYEAKRFEAMQKGKDGNTKYDVILDKEKEKLDHKKQRSAEKVEKSHNNNRYKITRTKNVEFGDLGKNSRDYEETEYSVI
The following text describes a protein:
Function:
Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.
Subcellular Localization:
Cytoplasm. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEPREVKDRILENISLSVKKLQSYFAACEDETPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAVKHIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTTLEWDDSAIAPSSEDGDLTDTVSGPRSTTSDPTSSKASTKSPTQRHNPFNEDQAETVSSSDTTPVHTSSQEKGESHTPDLPDTCTELEVIRVTKKKKTGKKKKPRSDEEASPLHPASTQHTCARQGNGDPVVSSPGPGQGSPDTTLASPPQEGQGPGSTVEGSERSEPGQVGLLIPEMKDTSMERVGQPLSKVIDQLNGQLDPATWRSHVEPPDQSFRTGSPGDAPERPPFCDFSEGLPAPMDFYRFTVESPSAVTSGGGHHDPAGPGQPLHVPGSPAAAGQEEAGGGGGPGQTPRPLEDTPGEAQKPEAQELDAQLPQDGEGLEPEPGTQEALCRLKGDQPSPCLSSAEDSGVEEGQGSPSEMTHSAEFRVDNNHLLLLMIHVFRENEEQLFRMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSPALCLAMAAPVAAAAKLRVHVGCGFRQVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEATAVTVRFYGLVHWEDPQDEFLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVTPLLSVNMGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGVAPSPCIPCCLVITDDRLFTCHEDCQTSFFRSLGTAKLADISAVSTEPGKEYCLLEFSQDSAQPLPPWVVYLSCTPELDRFLSALNSGWKTIYQVDLPHKAIQEASKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity). Regulates a photoperiodic flowering response. Transcriptional repressor of 'CONSTANS' expression.
Subcellular Localization:
Nucleus.
Sequence:
MMMETRDPAIKLFGMKIPFPSVFESAVTVEDDEEDDWSGGDDKSPEKVTPELSDKNNNNCNDNSFNNSKPETLDKEEATSTDQIESSDTPEDNQQTTPDGKTLKKPTKILPCPRCKSMETKFCYYNNYNINQPRHFCKACQRYWTAGGTMRNVPVGAGRRKNKSSSSHYRHITISEALEAARLDPGLQANTRVLSFGLEAQQQHVAAPMTPVMKLQEDQKVSNGARNRFHGLADQRLVARVENGDDCSSGSSVTTSNNHSVDESRAQSGSVVEAQMNNNNNNNMNGYACIPGVPWPYTWNPAMPPPGFYPPPGYPMPFYPYWTIPMLPPHQSSSPISQKCSNTNSPTLGKHPRDEGSSKKDNETERKQKAGCVLVPKTLRIDDPNEAAKSSIWTTLGIKNEAMCKAGGMFKGFDHKTKMYNNDKAENSPVLSANPAALSRSHNFHEQI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
Sequence:
MKTRAASASCRQGGGPVSGRARDQPGSGGTADSREEAEARGRGAEAELETGPPGRGTTPGKKSEARQSRGGKPRRGAPAEAARALELGVAGAPEWPELRIDSYPSSEERLGARRGRERLPSEEVTGGTRPRGTLGRAHPASPGGDGSAGAAPDVDLAPPKGFAGPGLHNPAPEEGLAATPRGKENSQGGVPSGETPSDSAVPDTDHETPESGTLRPGSGIGPHPLGSTWASATSSLLTGPTAGDSRPGPASPLTAGRTLGARASMEDSELDSQYLRSLLRPATRRSFALHSSPGKGRATASPAAGAPGSLQSPARATEKSEGEGETAGGWNTRPGPTGPSPRGVGGPPGIDGDRVPGESTPPPQEPALSAESQGIPGMSTPSRGSPLVSPLSSPRPAQGARASPAGSETPNDWLGGDVETRERAGFPENDAKEISAVFGRSNGTSGPGRGPRRQALKLASSEEDSSSEDDELPCFQDLLLGRAVSTPARPAGTAAPRDGSSHRAVRPATPPSRTSLEPELSQESEGSESLFSSGSLNCEGSAPRAGGPGSQRSPWADRTEGEADAGPGGRSRGDREADPNSGEASESASEASQPEDSSALSTQCDILTTQQRDAMQDNLKKLQQEMAALEAVLEGHESPAASAPAFSWPESGPQQHRPGEERTLEPRRNPTQPSTDTDPGPRGNGDPDPPASASSRRSPRGVPGSRPAAGCSTQERPGVSERSQEAPRPSGGRMALVASGLTQPELVLVQKFARKTQSILSSQFTAGTTHVVMKTDAEFVCERTLKYFLGVAGGRWVVSHLWVTQSFQEGRVLAERDFEVRGDVVNGRSHGGPRRARVAQDRELFAGLAICCLGPFTDMRSDHLEWMVELGGALLVKKPSLFPAGARVAPVLVVEPEAWAEDGSFQGIQRACLATVVTREWVLDSVARYERQDFGPYLVSHLLTPSPP
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MFYLYQSNRLETLAALFARIQKVKPLKSALQPEQIIVQSQGMRRYLNTCLARDLGVAANLSFSLPAGLTWKLMKKLIPGIPELSPFAPEVMRWRLLDLFRSEAFRNTAEFEDVRNVLQDYLGSGESADYQLAGQLADIFDQYLVYRPQWIDAWQQGRRLGLGDDEIWQSKLWRYLDDGRQSAPHRVALWEKLLESLSSDKLPERYFVFGISTMAPMYLQLLHKLSEHCDVFVFALNPSGMYWGNVIEAAQILKGGGDPDLTQAGHPLLASLGKQGRDFFDFLNEMEIEGETPVFEEGGRDTLLHALQTDIQNLKMPSEMAGSVNTGDGSIRIVSAHSPLRELQILKDKLLKILHEHPDWQPHDIAVLTPNIESYTPFIEAVFGQAQPGAQALPYSVSDVKISRRQPLFHALSCLFDLLESRFEVDKVLVLLETAPVLRRFGLTEDDLPLLHDMVADLNVHWGLDGEMRGGTDQLFTWKQAVERMILGWMLPKGGNPMWQDVSAWYADVNQTAMFGRFAAFLETLTDIVRIWRQPATVGEWVARCRDLLETLFQAEADDQKSVQNLENEWVKWQAETELAQFSGQLPPHTVIRHIRRFLDSESEAGFLRGGITFCSMVPMRSLPFKVICLLGLNDGDFPRNTKAAVFDLIAKHPAKGDRARRDDDRYLFLEALISAREILYLSYIGRDIRKDEELAPSSLLGELIDTVAAMAGIGSRQLAQNLIEQHPLQAFSRRYFQEGGRSDGIFGTRTDYAAALGQTPEPPQPFFDQPVENAEPVAEIGQDEFIRFWRNPVKVWLQQQLAWSEPHIGEAWEPAEPFEPQHADQIAEIYIEARCEGRDFAQTAARIGAESLLPSGELGRLWQQDFQTAAKQIDTAVLNSPKLPPLSYAIPSDGQILKGSLGNLYRCGQVFYAYGKPNAPQRIAFLLEHLIFCAVMPSEAEMRQTFIVQSGETEILAEIAQDRALQLLSEWMAFFNIGQNRPLPFFAKTSLATAEAFAQKQDWEAALKKAQTAYHGSKVSKGQKDYTEVALVFGNASQNPLEQPLFENLVRLLADTLAAAEKKEEAGEA
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis. Plays a role in cytokinesis during early development (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
The KA1 domain mediates binding to phospholipids and targeting to membranes.
Sequence:
MAVDDYEELLKYYELHETIGTGGFAKVKLASHLTTGEKVAIKIMDKESLGDDLPRVKTEIDAMKNLSHQHVCRLYHVIETPNKIFMVLEYCPGGELFDYIIAKDRLTEDEARVFFRQIVSAVAYIHSQGYAHRDLKPENLLIDEDQNLKLIDFGLCAKPKGGLDYHLMTCCGSPAYAAPELIQGKAYIGSEADIWSMGVLMYALMCGYLPFDDDNVMVLYKKIMRGKYEIPKWLSPGSVLLLSQMLQVDPKKRISVKHLLSHPWLMQGYSCPVEWQSKYPLGYVDEDCVTELSVFYKCSRTSTSRLISEWNYDHITASYLLLHSKKSHGKPVRLKRPLAVGDQPVTSFKELRPKSTLDFEEPNCGEIAYVFGSMEFSDDELFSEDFAYSCFEPHTPKEYVKGRSEFHSVDSAPSTPVVQRYARHKSEDKENCDAALGKDENVFLHPAPWTPTPRRKQNEKKGILTTPNKNSHTKEKNQSKETPTKKPITTGEELANVISPERRCRSVELDLNQAHVDSAQKKKGAKVFGSLERGLDKMITMLTPSKRKGYAREGPRKLRAHYNVTTTNIMNPEQLLNQIVKVLPSKNVDYVQKGYTLKCKTQSDFGKVTMQFELEVCQLSKSEMVGIRRQRLKGDAWVYKRLVEDILSSCKV
The following text describes a protein:
Function:
Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage.
Sequence:
MEEREALKRQIELLQNLINKHKSIHGDAPFNRAEQRLPETSAAARGFSDVHRGSRGKPYEAQNRGSWRRTYSLKNKSPQGSGTSSMSSFSHQSTSHSFPLPSQSRGVPTNPTKSAASLPLKKKVSTAGLQGEKKKQSLSPAGGSLTHEAPKFQQRAEARQVLLPQKKERASTEVPPSSKAKSASPLFTKTTNNSCQIISAAAPLKAAHTMPALPDLSTKHLNVSSATGPRPDFPKTSKFTWVKSQDSFKDDSRQITSPSKKAAAVTISVSGGASGVPPAGALSKRTPPKKVARKLGPVSAATKTSKYKWVCAAGSQSRALRKLPSPKSLTPQRSLEKGDVTRKLKPTSTPPAKLKKGASGNLSVYNRYRWKAGAQGPSGAEGGALASPLRRSAFHWTAEKSSKGMKAGLLPPAAPHRPCPPSALPGGFKLRSRMKIIRRYSSSGGSERGGGQSAVKFSPRSRMHASIRSPAGVRRTPSRELVSFGRHKLRRLSSPPTRTNPSSSSHRSPASQRVFRTRYKMVTRPGSSPTNTLNYNPALSWRARRIHYARSFLQNRLRTPPDRHPSPSQRWARSGICWIRGSLYRVSANKLSRTANMSINRTGRLPGSSLARPSSTRHLASRAVQRSIAIIRQARQKKQQKQYCMYYNRFGKCNRGTSCTFIHDPDKVAVCTRFLRGTCKREDGTCPFSHKVSKEKMPVCSYFLKGICNNSDCPYSHVYVSSKAEVCEDFVKGYCPEGEKCKKKHTLVCSDFFKTGSCSRGSRCKLQHRQRLKRTSSNTSSAPGKRTRSKEPQKRPTLSIIMPKDAQTPPRTLPTGLLALPSFISLSSSPEEADPLDTLPADTTQVKEKKLQIKPRLRPDTS
The following text describes a protein:
Function:
Probable transporter of a GTP-driven Fe(2+) uptake system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSQNTYCLLGNPNTGKTSLFNALTGSYEYVGNWSGVTVEKKVGTLRSKTGKLIDLPGIYDLNPISRDETVVTRFLLEEKFDCMLNIVDSSQIERNLNLTIQLLEFGAPVVMGLNMIDVAAGRGIHLNIQNLAKKLRIPILPVVARSGKGTDDILTTLSEKHVAPAIPLVLPYGEPAEKAIAEIQALTKDIIPTKQSRWLAVQFLSKNEVTEEFLTTSPMFEQLKDIRSDLEIALAGKLENHFHQVRVNYIHDICLTSVEYTRNSDIPLSDKLDKIFTHKFFGIPIFLGIMWLIFQITFTWVGAPLSDLLDGFIGGSLTDWVTSFLTTIGASGFITDLVADGIIAGVGGVLVFVPQILVIFFFISVLEDSGYMARIAVVMDRVMEIFGLNGKAFIPMIIGFGCNVPGIMAARSIEESKERTLTILVSPFMSCSARLPVYALFVGVFFEKYQALVVLSLYVIGILMALIVTKILSKTLLKKDNSVFVVELPPYRLPSLKTLWRSTWEKGKGFLRKAGTFIFAGSVIIWLLNYAGPSGLDVPMGESFLAIIGGMLAPLLVPLGFGTWQAGATLIPGFLAKEVVVSTMAIIYAVGESSMGSIVSTFYTPLSAYCFMLFILLYIPCLATVAAIRKETSSWKWTAFAVAYPLITAYVLVFLVYQIGSLFV
The following text describes a protein:
Function:
Potential transporter for phosphate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MALSVVFVVGVAAAIFVGVNIGGSSTGVAFGPATGSDALSMRQASGLMAVFVLLGGFTIGTNVVDALGADFIPAEYFTLGASIGVLLFIGLGILIGNVLNVSTSTSQTAVAAVVAMGAALGVLDWRTVGVVGMWWVLSTTLAFWICAFVGRYFYDAIVNLLSFESDDTGRFAELVVIGIGCYMGFSTGASNVASAVAPLVGSRQLEMTSGVAIGGVAIGVGAFAIGPRTMETVGEDITDLSLEASPDR
The following text describes a protein:
Function:
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). May control nuclear division through the microtubule cytoskeleton.
Subcellular Localization:
Early endosome. Late endosome. Prevacuolar compartment.
Sequence:
MVPPPSNPQQVQQFLSSALSQRGPSSVPYEESNKWLIRQHLLNLISSYPSLEPKTASFMHNDGRSVNLLQADGTIPMPFHGVTYNIPVIIWLLESYPRHPPCVYVNPTADMIIKRPHAHVTPSGLVSLPYLQNWVYPSSNLVDLVSDLSAAFARDPPLYSRRRPQPPPPSPPTVYDSSLSRPPSADQSLPRPFPPSPYGGGVSRVQVQHVHHQQQSDDAAEVFKRNAINKMVEMVHSDLVSMRRAREAEAEELLSLQAGLKRREDELNIGLKEMVEEKETLEQQLQIISMNTDILDSWVRENQGKTKNLVDLDVDNAFECGDTLSKQMLECTALDLAIEDAIYSLDKSFQDGVVPFDQYLRNVRLLSREQFFHRATGSKVRAAQMEVQVAAIAGRLHS
The following text describes a protein:
Function:
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEEQVNLSAGLAPDCEASATAESTVSLVGTCEAAAKSPEPKDSDSTCVFCRIAGRQDPGTELLHCENEDLICFKDIKPAATHHYLVVPKKHIGNCRTLRKDQVELVENMVTVGKTILERNNFTDFTNVRMGFHMPPFCSISHLHLHVLAPVDQLGFLSKLVYRVNSYWFITADHLIEKLRT