lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Target of p53/TP53 with pro-apoptotic function.
Miscellaneous:
MISCELLANEOUS: Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MSEVKSRKKPGPKVAAPEPEKRSDGRKNPEARGDAGWADPRTGLSLLSLAMTLGLAWLVFQQSEKFAKVEKQYRLLQTESSEFQGLQSKISLISSKLESTENTLQEATSSISLMTQFEQEVSGLQRSIRDIETSEEMLTQKMQNLNEKFQNITDFWKRTLAEMIDDTAVFKSEVKDTHSEVTLKINSADQEIKSLTERLKDLEDSTLRNIRTVSRQEEEDLLRVEAQLSSDTKAVKKLEEEQHTLLARDEDLTNKLSSYEPKVEECKAHFPTIENAVHSVLRVSQDLIGTERKMEELTMQMFNMEDDMLRAVSEIMEMQKTLEGIQYDNSLLKMQNELVVLKGKVHDFIAYSSAREKGTLGEYSLGNKGTDEY
The following text describes a protein:
Function:
Probable transcription factor required for axillary (lateral) shoot meristem formation during vegetative development. Seems to act upstream of REVOLUTA.
Subcellular Localization:
Nucleus.
Sequence:
MLTSFKSSSSSSEDATATTTENPPPLCIASSSAATSASHHLRRLLFTAANFVSQSNFTAAQNLLSILSLNSSPHGDSTERLVHLFTKALSVRINRQQQDQTAETVATWTTNEMTMSNSTVFTSSVCKEQFLFRTKNNNSDFESCYYLWLNQLTPFIRFGHLTANQAILDATETNDNGALHILDLDISQGLQWPPLMQALAERSSNPSSPPPSLRITGCGRDVTGLNRTGDRLTRFADSLGLQFQFHTLVIVEEDLAGLLLQIRLLALSAVQGETIAVNCVHFLHKIFNDDGDMIGHFLSAIKSLNSRIVTMAEREANHGDHSFLNRFSEAVDHYMAIFDSLEATLPPNSRERLTLEQRWFGKEILDVVAAEETERKQRHRRFEIWEEMMKRFGFVNVPIGSFALSQAKLLLRLHYPSEGYNLQFLNNSLFLGWQNRPLFSVSSWK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTVDAMDVDSSPAPAAVAEPERKRKHKHKDHSSKKKRKHDSNLIAETTVHETTSKKSSKSKEKSKQKSSGNAPLPSGSPYVLTTATLYLPLSPISISPTHALASLLAEHLSPLLLTYYSPLQGVILAYSNASISSEPPSASSPSSDPQDNPQPLTLAKSADEYGVLYVYLTATFLVFRPQRGQILEGWVNVQSEGFLGAVVLNLFSVGIERKRLPSDWKWVPPGEEEEGNGFNSSGKPKKKVFSSTEDEDDSEPSSHFDPEKEHFKPISLASDANPFSETMDPNNGPAADDDDDDKSAAEGYFQSVSGHRVRGTVRFRVVDIDVIPGSDRERGFLSIEGTMLSPEEEARVLDDERNGNYSSMTPRPQGQWEPSSTMSGALAGLSSAAPSTADADTGALEETPSKKKERKPEKEKKSKASKSKKKKEEK
The following text describes a protein:
Function:
May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.
Subcellular Localization:
Secreted.
Sequence:
MKGRSALLRALWIAALSFGLGGVAVAAEPTAKAAPYENLMVPSPSMGRDIPVAFLAGGPHAVYLLDAFNAGPDVSNWVTAGNAMNTLAGKGISVVAPAGGAYSMYTNWEQDGSKQWDTFLSAELPDWLAANRGLAPGGHAAVGAAQGGYGAMALAAFHPDRFGFAGSMSGFLYPSNTTTNGAIAAGMQQFGGVDTNGMWGAPQLGRWKWHDPWVHASLLAQNNTRVWVWSPTNPGASDPAAMIGQAAEAMGNSRMFYNQYRSVGGHNGHFDFPASGDNGWGSWAPQLGAMSGDIVGAIR
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPHNDPDGPPPERSARVRPRRQSGVPAVRPHRFVDPRFSDLYGAVDRKQFEDNYKFLREQEEEEQSRRKHCIQCLKYALRRHEREEVGQDEESEEEEDRFEEENRDEINRLMLRPPSDLKAELQQLKRESQLYISRTKDREVRARRQAVRKGIIKREAAAVRDGKKQRAFIPKRSQLKREVLAETFDKLEKKGGKGAVDKYVERKTKKRR
The following text describes a protein:
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Sequence:
MAAANPWDPASSQTAAGLLLNHLVASGIVTKEMLDVSKKMAPCFVNFSRLQQISDIQAEIYQNNLELELLKLEKDTADLIHPSHLIEKCDVLQSMNNHLEAVLKEKHAIRQRLLRPMCQENLPLEAVYHRYVVHMLDLAVTFIEKFETHLETVKNSPHLDANLKQMSKALAKMDILVNKTEELAENILKWRELQTEISLYIPKMLTEERHLHELDIVPPLPFFPKAHTETSRAK
The following text describes a protein:
Function:
G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand. Stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue once activated by kynurenic acid (By similarity). In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation. In turn, induces chemotaxis of macrophages (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid.
Sequence:
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
The following text describes a protein:
Function:
Flagellar protein that affects chemotactic events.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMSKKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILTEKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH
The following text describes a protein:
Function:
Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP.
Sequence:
MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAERTEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISVKGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK
The following text describes a protein:
Function:
Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEFAKIRGKSYQDCLMEMKMKYGSEATVISQTVVTEGGVMGTGLLAKKMIEIQIGIPEKQASREKIERKLQDLKDLLKQKSYASPERKKTLQTLKPLSKTLEEKEIAVEEEIEEITTEPDRVGLSFEKELLDKNSFLRRDTSTVRKDSPLIRLGEKLVREGMSQSYVEEIISKVEERLSPLDQGRNHAVLERTIEILKERVSVDSDLFRGTGKNQRKVIFFVGPTGSGKTTSVAKLAAKYFLHRGKSVSLYTTDNYRIAAIEQLKRYADTMGMPFYPVKDIKKFKETLARDGSELILIDTAGYSHRNLEQLERMNSLLSCFGEKDSVENLLVLSSTSSYHHTSTVLKAYESLNYRRILLTKLDEADFLGGFLELADTYSKSFTYYSVGQEVPFDILSAEKNLMAECVVTPEKIAELRGEVFTVAGD
The following text describes a protein:
Function:
Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own expression.
Sequence:
MSGAFNNDGRGISPLIATSWERCNKLMKRETWNVPHQAQGVTFASIYRRKKAMLTLGQAALEDAWEYMAPRECALFILDETACILSRNGDPQTLQQLSALGFNDGTYCAEGIIGTCALSLAAISGQAVKTMADQHFKQVLWNWAFCATPLFDSKGRLTGTIALACPVEQTTAADLPLTLAIAREVGNLLLTDSLLAETNRHLNQLNALLESMDDGVISWDEQGNLQFINAQAARVLRLDATASQGRAITELLTLPAVLQQAIKQAHPLKHVEATFESQHQFIDAVITLKPIIETQGTSFILLLHPVEQMRQLMTSQLGKVSHTFAHMPQDDPQTRRLIHFGRQAARSSFPVLLCGEEGVGKALLSQAIHNESERAAGPYIAVNCELYGDAALAEEFIGGDRTDNENGRLSRLELAHGGTLFLEKIEYLAVELQSALLQVIKQGVITRLDARRLIPIDVKVIATTTADLAMLVEQNRFSRQLYYALHAFEITIPPLRMRRGSIPALVNNKLRSLEKRFSTRLKIDDDALARLVSCAWPGNDFELYSVIENLALSSDNGRIRVSDLPEHLFTEQATDDVSATRLSTSLSFAEVEKEAIINAAQVTGGRIQEMSALLGIGRTTLWRKMKQHGIDAGQFKRRV
The following text describes a protein:
Function:
Binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon.
Sequence:
MDGRRRNPYELTEDTPVYVISVAAQLSGLHPQTLRQYDRLGLVSPDRTAGRGRRYSARDIELLRQVQQLSQDEGINLAGIKRIIELENQVAELQARAAELAAALDGAATAMRQREAAVHASYRRDLVPYQEVQQTSALVVWRPSRRGQSSD
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MTSGQDPNALFEQHTRTDCDPANYDRVHKKPRCPVAGCKTKLTTINRYRCKHCSQAICLKHRDPADHRCAEVQAANRQQRGGFFSSRPPAATSAAAASSSGRSSGAASAASSRPPSAPRPAPGAASSVTTTSPAAARRPSPQELHAAAARQYEDPDNSLRGTAARRAAQAAAPPPPAQSRWPWQSTPLTTGTGTSTSTSNANPLVPPHRPEKCPQCGAAFETVARLIQHVEDFHPSQQPVGTSTAAGGGPAGGGAAGPDAAGGAGAGAGGAGFFSNPLRGLAGTTIAGGPAPAGGGTFGGFGGAVGVQTDVNRGAGGGGGGGSLLSSGAGSGPGADGREVYRCHMCSRTFNDPVMLVQHSERCGAAARVGAGRGGGSGASKDTCVLS
The following text describes a protein:
Function:
Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.
Subcellular Localization:
Secreted.
Sequence:
MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP
The following text describes a protein:
Function:
Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs.
Sequence:
MNRNCASPEEGGTTEQLVKEASDIVERDGFENKKKPPTLKLEHVEVVGEKSPTPATVYDLFKKYKKPDIVTNSNGDDMNVGFDQLSSDEKNGFLRKLQMLTVSSRKSVKVVGESTPSSAGRLLKKFAPSRKPTEKISVDEPPSRFNFFGRSTKKLSDSDRPSSLPKKKSARRLLFGKEEQKPEPEVVKNRVLPAMTSQQSAKGAPIPINKPYRYQGPRGSLETPTDSPAKISSNSSSSSPIPPVPTRNHFTSMNEESPSKKRTFSRQGLSNRDNLSNGSWHGELPPRDYTSPTFSRKIFVGGVPWDITEAALKDSFGEFGSCAVEWPGQEARYRSGQSNIAPLTNLRNQSKYAGQAATGYVYMIFEDERAVASLLHECSQEIGGAGEWYFKIRAQRSKSTEIRQVQIIPWVTSDSMFCEDESLLETGIEPKRTVFVGALHGMMTAQVLHWIMEDCFGSVECVQLDTDKFKYPIGSGRVTFREHGAYFKAIEMGYLHVHTSKFRKRVQIDPFLESTSCMVCTTESAQCFCRNRNCFKYYCHTCWAIDHGKDNADDVHVPVIVPSSASKAYAGPHRRPHLTSNSLSKSHGCSTNNQLSHVLSPGFPMIVGGPSQTLSALYGYIQNNQQMMLTPAVYETPMTPPSNESNAKRRSFTEFQNPAIFFNPSSMMTPQKSATCSETPVPAFFTNSAAFLTPNSNYYGSPNHSSSNISQSPQQYYGANLYYGYMPPQVAYDGSTNGSKLSPIHVPHIPNYQ
The following text describes a protein:
Function:
Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione.
Sequence:
MKSRAAVAFGPGKPLEIVEIDVAPPQAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVLGHEGGGIVEQIGEGVTGVKVGDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIFHYMGCSTFSEYTVVPEISLAVVNPEAPLEKVCLLGCGVTTGIGAVHNTAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKGRTQLPGMVEQSMKGEIDLDPFITHTMPLEQINEAFDLMHEGKSIRTVIHF
The following text describes a protein:
Function:
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRDSYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVASLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSSDLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNKLTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYNQIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRNDSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAEDPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNLNSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ
The following text describes a protein:
Function:
Chaperone necessary for the assembly of mitochondrial respiratory chain complex III.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNHLKDQSKSIVLGISSGIGIFLISGGINIFKNVGQYILNRINSNIYYRIDVDSKDKSFEWLLYWLSENDSIKVSNHLNAETVYNLVGKNPKVILVPSVGKHRIVYKGKWIWIDRVRDQQFDMGAGAPFESISISTYKSNAQLINQLLQEAMTLSLNRDIGKTVIYINGGNGNWERFGNPRSIRSLSSVILADDLKSKLIEDIKSFITNESWYRNRGIPYRRGYLLYGEPGNGKSSLINAIAGELNLDICIVSLSSKDIDDKQINHLLNNAPPKSILLIEDIDAAFKSHRDNVDSNNNNSNNNNSLTYSGLLNALDGVASQEGRILFMTTNKIELLDSALIREGRIDLKIKVSNATKSQAAQLFTHFYNLPTDNQLAIRFSENLHDHQLSMSQIQGFLLKYINSPEKAIEEVQSITPFNLN
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MSVSFKLAPVGDYWANNENRWNIELGRHRHKQLLINHAAIGMNLDEGYNNFENEHGGERIESILAYIMKTARIGIPLKEMIEADIVCRRGLLRNLSINKYTGHYINFYAVRHRGVIFLCEDKDFGGAPDKLRRAMYHTLKFENVMTVPQSRDITASRKEATKMVIRGCLEKEGAESIRLFYAADIDCLDIYGSPVEFKSISKPLETGWDKNRTMAWYMQCFFASVNTIVVGERQRSRLRTVRHYRKSIKTMNVEAFYTHRNHSWTRESCIEQLYGTLSFVKHHMSLDGMALKFSVINGTNYLATTQYGEYIVPQNFLRVFPF
The following text describes a protein:
Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
Sequence:
MPKCPKCSKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAATFGPKGFGRGGAESHTFK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MENLDEVQWRSPEWIQAHQGLRTDNVLDYFAESPFYDRVSNNQVLRMQTQFNQQQTGQLTPQHFEQELQKMTGIEFVITHVREPDLWVIKKQNRLNPQQTTPISTYFVINENVYMAPTVAAIMQSRVLSTSMFLKRALEEAIELPSYSPSQGYTYEDSQLTTAGDDDSTPQASKAELGLLERSFRAAISGQQKYVSDIAPISSQSESAASSVPGTPVLKGRKLPLKK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MRRFILERNPTNVKNMAKLSPIPHTLLGIRKFMLERNHTSVINVAQPLFYPQPLVNMRRFILERNSTNVKNVAKPSTIFHTLLYIRQFILERNAINGIKTFTWSSSPHKHRRTHTGEKPYKCEECGKAFTASSTLSEYKTIHTGEKPCKCEECGKAFNWSSDFNKHKRIHSGQKPIL
The following text describes a protein:
Function:
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Sequence:
MPLLDSFKVDHTRMHAPAVRVAKTMTTPKGDTITVFDLRFCVPNKEILPGKGIHTLEHLFAGFMRDHLNGNGVEIIDISPMGCRTGFYMSLIGTPSEQQVADAWLASMQDVLNVKDQSKIPELNEYQCGTYQMHSLAEAQQIAQNVLARKVAVNKNEELTLDEGLLNA
The following text describes a protein:
Function:
Inner capsid protein that plays a role in viral DNA ejection into the host cell.
Subcellular Localization:
Virion.
Sequence:
MKVTANGKTFNFPDGTSTEDIGAAVDEYFAGQASAAETQPAEQQEEPQQPEQSLMQRAGDLLTGGQSAGQIAEQAGRGLVNIPFDVLQGGASLINAISQGLGGPKVLDDVYRPVDRPTDPYAQAGESIGGYLIPGAGVAGNMAIGSVAEAANQQGDFAGNVAKNAAVNLGAQGLLSGAAKLVGRGITAARGEIAPEARQLIDTAESMGVKPMTSDMIKPGNAFTRSLMQGGEGALLGTGGKRAEQYAIRSKLLGDYFDRVGGYNPDDIVKSMTSTVGGRKNAAGAVRDEIVNRMGSAPVGTTNSINAIDTNIARLEKLGTSADQRLLTALKNLKGELNSGNVDFDLLQQHRTAFRTNVQGDAMVFPNQAKAATNMVENAMTRDLRNAVGKSLGPQDAAKYLKSNSDFANIYNKVLNKRISNTLNKARSEYTPELINTVVFSRKPSDIKRIWSSLDNKGKDAMRAAYISKIAEKTGDSPAKFITEVNKLKAQSGGEIYNTIFSGRHMKELDALHDVLRQTARSDSANVVTQTGQALANPVRLGAAIPTLGKSLAAEAGYGLAMRVYESKPIRNMLLRLANTKPGTPAYERALNQAATAVRPLLANEATRQ
The following text describes a protein:
Function:
Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Localizes mainly in the cytoplasm in stage I spermatocytes and at the cell membrane in stage II spermatocytes and in spermatids.
Sequence:
MSGVELQPESTQSEEKEEPKTAATTISSTEETKTENPNVALDNLAKTPIQLILQPTPQTPAKTPETPRIQKINNLKKSASFDSKNQPEDSKTPKQRDQLIEVPSDEVGRVENNIDNLPFYHGFMGRTECESMLSNHGDFLIRMTEVGRRVAYVISVRWHYQNSHVLVKRTKTKKLYWTKKYAFKSICELIAYHKLNQIPFYDNMTLICGLARHEWQLNNEQVTLNKKLGEGQFGEVHKGKLKTSVFTPPVIVAVKTLHQNHLSANEKILFLKEANVMLTLAHPNVIKFYGVCTMKEPIMIVMEFCDGSSLEDVLLSKESKVSSEDKILYLFHAACGIDYLHGKHVIHRDIAARNCLLNSKKVLKISDFGLSVKGVAIKERKGGCLPVKYMAPETLKKGFYSTASDIYSYGALVYEVYTDGKTPFESCGLRGNELRKAIIGKSVILTIDVECPEFVKAIFEQSRLYDTEQRISSKRIIEIFKEEAGMHELDATGLFGRIGSFFSRVRRQKEAEPSVPILT
The following text describes a protein:
Function:
Cytochrome P450 involved in the production of catechol-substituted substrates needed for the arabidopyrones biosynthesis. Converts p-coumaraldehyde into caffealdehyde.
Miscellaneous:
MISCELLANEOUS: Arabidopyrones are derived from phenylalanine instead of tyrosine like other ring-cleavage-derived plant metabolites.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLTLMTLIVLVPLLLFLFPHLLLRRQMLLKPYPPGPKGLPVIGNILMMNQFNHRGLAKLSRIYGGLLHLRLGFSHIFVVSSPDIARQVLQVQDHVFSNRPTTIAIRYLTYGGSDLAFCNYGPFWRRMRKLYVMMLFSRKRAESWVSVDEEVHKSVRLVASNVGKPLNICKLAFSLSRDITFRAAFGSSSSTSDESRLDEFLEIIQEFSKLFGEFNVADYVPSWLSWIDPQGINGRVEKARKSLDGFIESVIDDHLHKKKREHDNVDEETDMVDQLLAFYEEEVKVNNSVTKINLDNIKGIIMDVMFGGTETVALAIEWVLTEILRSPENMKRVQDELTSVVGLDRWRVEDTHLEKLTFLKCILKETLRLHPPFPLLLHETVKDTEISGYFIPKGSRVMVNTYALGRDPNSWSDPESFNPGRFLNPIAPDLKGNNFEFVPFGSGRRSCPGMQLGLYAFELAVAHLLHCFTWSLPDGMNPGDVDTVEGPGLTVPKAIPLVAVPTTRLLCPIVVS
The following text describes a protein:
Function:
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Sequence:
MLLSEIAKIIEGELIGEDMDIEKVAEWEIATEKDLIFVFNSKDIDKIEGKTKARSLVIPLDGKSNKTHIKVENPRLAMAKLLKFFDFRIYPSGVHDTAILGKNVELGEDIGIGAYVVVGNNVKIGKGTKIFPGVVIGNNIEIGENCIIYPRVTIYDHVIVGNNVIIHSGCSIGVDGFGYVWNGKEHFKITHIGKVVIEDNVEIGGNTVIERATLGETKIGKGTKIGSLIMIGHNVKIGENCVIVSQSGIAGSSELGNNVVMAGQSGVSDHVRVGNNVVILAKSGVTKDIPDNMVVSGFPARPHREEMKIQAILKKLPDLWEEIKKLKKT
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADLKEPPGQTSPPPPPTTTTTTTTRALRGASLLILLQILSRALTFIANQILLRFLTASLLGVSTQLEVYYLSVIFFARESLRVAIQRQDTTTLSASLLSSSTSTPSETAKDGKDGAEKDTAAATQAVINLSHLSLLLSLPLAFLFGRLYLSSLSLSTLQSTPYLVPSLYLYGLAAILELLSEPCFAVMQIRFQFGVRAAAESVATFLRCAVTLGIAVWGARTGREMGTLPFAVGQCVYAVGLLAVYLWKGWKLSGREGFSLWPRRLLLLSGGEKKQQQQQQQQQQQQQREDGKGNGEAEGGKKQDLFVLGYFYRPTLDLASSMMAQSVVKHILTQGDTFLVSILSTPTAQGVYALANNYGGLLARLVFQPVEESSRSYFSRLLADSSTSPSSKPSSPSSKPSSKPSSTALHQASSSLTTLLKSYLLLSLPLLVFGPPASSPLLTLIAGRRWTSGPSSSSSSSGSTTTVPVDSAPATLSLYMYYIPLLALNGILEAFVSSVASEAQVHRQSLFMTFFSLVFAGTGYLTLKVWGMGARGLVVANAVNMACRIVWCWGFVGRWFAERSGTGDGKVGEKGGKKDGEEDEKEKEKEKVRFGVLDVLPKPGAVAAAVVARSVVGRVVGASQEEVVMGAKEAVWELFKIAGVAVPFVVAVAIAERDFLLSGYRALQGKRQQQQQKS
The following text describes a protein:
Function:
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
Subcellular Localization:
Secreted.
Sequence:
MGVWLLSLITVLLSLALETAGQGERIIDGYKCKEGSHPWQVALLKGNQLHCGGVLVDKYWVLTAAHCKMGQYQVQLGSDKIGDQSAQKIKATKSFRHPGYSTKTHVNDIMLVRLDEPVKMSSKVEAVQLPEHCEPPGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWGTYPCGQPNDPGVYTQVCKYKRWVMETMKTHR
The following text describes a protein:
Function:
Catalyzes the addition of fucose in alpha 1-3 linkage to GalNAc-beta-1->4-GlcNAc-beta-1->3-Gal-beta-1->4-Glc (LDNT)acceptor. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-alpha-1->3-(GlcNAc-beta-1->2-Man-alpha-1->6)-Man-beta-1-4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (GnM3F6) acceptors.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MKHNTLRAVFQFSFFIGICTFIMIAGYSYQINYNQRMGIFYGGNITFKKVPKVVIYTATPFFDVPIENSILRDCSEKIKNSCTVTSNNKTFPIADAIVFHSRDINETKLSFFNKNRRYDIPYIMMAMENPFFAGLTVYHNFFNWTMTYRTDSDIFHPYGAFVKSYVPAEVNYSEIWNSKTKETLWMVSNGNAQNKRKELVEKLIKKGMSIDLYGQLYKKEPAECPRRRGPPGCDVKFHSPYKFAIAFENSNCKDYVTEKFWKKAGIYKTVPIVMSRKIYRDLGIPDSMYIAVDDYPNLEEFVHHIQNVTSNEEEYMKYHKWRKQFKIVDTNEGNIGFCQLCQKLAGYKRKLVPHKVYENLNSWHSTSTCDNSFATRFL
The following text describes a protein:
Function:
Essential for Golgi structural integrity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Golgi apparatus.
Sequence:
MWLYTFAVALIVIAQEINGEPHTRPSSATPLNATLPPQEEGSAQNTTDAAVGSRLSTILRDLPTIKNISIFICVLTTLLITCLVIKICRSARKIRKTRKYDIITTPAERVEMAPLNEENDEEDDSTLFDVKYR
The following text describes a protein:
Function:
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity).
Subcellular Localization:
Synapse. Cell membrane; Lipid-anchor. Note=Enriched at the synaptic terminal (By similarity). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (By similarity).
Sequence:
MAFMVKTMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQMAGGDVELPRELAKMIEEDTEEEEERASVLGQLASLPGLDLGSLKDKAHSTLGDLKQSAEKCHIM