lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in membrane protein folding. Required for localization of MPS3 to the nuclear envelope.
Miscellaneous:
MISCELLANEOUS: Present with 3250 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MANRLLIYGLILWVSIIGSFALDRNKTAQNAKIGLHDTTVITTGSTTNVQKEHSSPLSTGSLRTHDFRQASKVDIRQADIRENGERKEQDALTQPATPRNPGDSSNSFLSFDEWKKVKSKEHSSGPERHLSRVREPVDPSCYKEKECIGEELEIDLGFLTNKNEWSEREENQKGFNEEKDIEKVYKKKFNYASLDCAATIVKSNPEAIGATSTLIESKDKYLLNPCSAPQQFIVIELCEDILVEEIEIANYEFFSSTFKRFRVSVSDRIPMVKNEWTILGEFEARNSRELQKFQIHNPQIWASYLKIEILSHYEDEFYCPISLIKVYGKSMMDEFKIDQLKAQEDKEQSIGTNNINNLNEQNIQDRCNNIETRLETPNTSNLSDLAGALSCTSKLIPLKFDEFFKVLNASFCPSKQMISSSSSSAVPVIPEESIFKNIMKRLSQLETNSSLTVSYIEEQSKLLSKSFEQLEMAHEAKFSHLVTIFNETMMSNLDLLNNFANQLKDQSLRILEEQKLENDKFTNRHLLHLERLEKEVSFQRRIVYASFFAFVGLISYLLITRELYFEDFEESKNGAIEKADIVQQAIR
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MPAKRKHPEPKEEPKVEVPVEEPEEDEDEEDEDEDFGGFLGPREPEEYNPGPVDLNPLQFLVAPTDLAEFMKSKWEKAPLHIPATEERKEFFEGLFDFKALCRIADQMEAGALILMDQDPGEKGDALGLDDDVNDEMIRDIGPLVFGRDVVAVRYIDGKREEIRASFADSEALKQLHDDARATLQLHQPQRFVNACWRLLAALESQLGCLVGCNAYVTPPGGQGLAPHHDDVELFVCQTQGTKSWKLYKPAEGCELPYNPSGDLEQDALGAPMLEVTLQPGDVLYVPRGVVHQAAAEEAGSCHLTVSTYQHWTVGNLLGEVIKQGMAPDALEHVPLELRRGLPVGAIYKHGLTVDMQSKSQAELLAAAQPDAAAVAAALRKLAAAVEAHPVELVSPAVEAMAADFLMHRLPPHPAQLPDSGEEPDSLEDAVYCRGARLFRLVPCEHEDDEEDEDEEEEEDEEEEEHEGPFVRLVTPLANSRYKHMINKPLPDEEEEGDSEDEEGHVHGPGCGHHHHHDEDEEEEGAEEEEEEDKEAKGKKGANGKAEKAEAAAGKKGGKKQEEEEEGEGEDDAEMEEADVDDVDSDELAAAMGGDDDDEDEDDDEEEPEELPGPVFPAAYAPVLGAVLASTADKPLRVSELQVPGDDDQRLRLAVLLHDMGIVVCVKKGGKEEEKEEKQKEEEEPKKGKKEAKKAEPKTKEEEPAKKGGKKEAAPKKEAAPKEEPKKEEAKKEEAKLKGKGKGAAKEAAKPTEEAPKSGGKEAPPAKKAKKGGK
The following text describes a protein:
Function:
Utilization of purines as secondary nitrogen sources, when primary sources are limiting.
Sequence:
MVYANNNIDPNAPCYVSECAELLSDKVGGVVLGCTDQWFAECVNLIKHSAPVWDAEKYVDTGKWMDGWETKRHNPDHDWCIIKLGIPGVIYGFEIDTAYFTGNYPPHASIEALCDDSDPNFNTLKESNNWEVILNKSDLGSSCKKYFECKVEKRFTHIKFRIYPDGGVARLRAYGRVVKDWTLVIPGELVDLAAIENGGLVTQVSDHFYGNKNNIIMPGRSVNMGDGWETKRRRGPGNDWLTVKLAKEGIVKRIEVDTNWFKGNFPTSCSIDAIHSSSAPDETHLQDYEWTNILPNSPLCGHRRHFFQNELVNNDKPFTHIRLNIFPDGGVSRLRINCSLPDSKNNNNNNNNNNNNNTSNSFKTSDRQQ
The following text describes a protein:
Function:
Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
Miscellaneous:
MISCELLANEOUS: Binds magnesium, but the ion is dispensable for mo5U forming activity.
Sequence:
MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGMEVLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQLDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDNVLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSGMVDLKEFLAELGKTQKELKNVIEQAKDIGLELKTNSKMTPEQAGKLYKYIVDGIKEQIQANQPAKNPEQDNKDDLNTAVASKSLNKKVSKTPKKEETKSQPKPKKTKEKKKEAPTPIAKKKGGIEIVNTFENQTPPTENTPKVVSHSQIEKAKQKLQEIQKSREALNKLTQSNANNASNANNAKKEISEVKKQEQEIKRHENIKRRTGFRVIKRNDEVENESENSVTESKKPTQSAAAIFEDIKKEWQEKDKQEAKKAKKPSKPKATPTAKNNKSHKIDFSDARDFKGNDIYDDETDEILLFDLHEQDNFNKEEEEKEIRQNINDRVRVQRKNPWMNESGIKRQSKKKRAFRNDNSQKVIQSTTAIPEEVRVYEFAQKANLNLADVIKTLFNLGLMVTKNDFLDKDSIEILAEEFHLEISVQNTLEEFEVEEVLEGVKKERPPVVTIMGHVDHGKTSLLDKIRDKRVAHTEAGGITQHIGAYMVEKNDKWVSFIDTPGHEAFSQMRNRGAQVTDIAVIVIAADDGVKQQTIEALEHAKAANVPVIFAMNKMDKPNVNPDKLKAECAELGYNPVDWGGEHEFIPVSAKTGDGIDNLLETILIQAGIMELKAIEEGSARAVVLEGSVEKGRGAVATVIVQSGTLSVGDSFFAETAFGKVRTMTDDQGKSIQNLKPSMVALITGLSEVPPAGSVLIGVENDSIARLQAQKRATYLRQKALSKSTKVSFDELSEMVANKELKNIPVVIKADTQGSLEAIKNSLLELNNEEVAIQVIHSGVGGITENDLSLVSSSEHAVILGFNIRPTGNVKNKAKEYNVSIKTYTVIYALIEEMRSLLLGLMSPIIEEEHTGQAEVRETFNIPKVGTIAGCVVSDGVIARGIKARLIRDGVVIHTGEILSLKRFKDDVKEVSKGYECGIMLDNYNEIKVGDVFETYKEIHKKRTL
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERDFLGLGSSEPSGVVKEEETSTEACGGSGLNKVSGARWPFLEKFHAVPHLKLDLPGHGLVFTPNSDLLGAASTLGTTESSYCRNAAKPHGSPQLTIFYAGSVKVYDDIPPEKVQAIMILAGNGTSKSPKASHSKCYVHTPTTGNITGNHVVLTQPITQPCSGLSSPFSVASLPAPHLGSGLTNKNGPKEGNAEGVTALSKVDSPKMVGAMRSIAATTMMSTAIPQSPKASLTRFLEKRKERLRNAAPYHLGKSLSLECASPDSSPMKLSSGPALDKHCTR
The following text describes a protein:
Function:
Probably involved in intron recognition and spliceosome assembly, but not involved in alternative splicing regulation of the SCL33 intron.
Miscellaneous:
MISCELLANEOUS: The splicing pattern of the pre-mRNA is regulated in a tissue-specific manner and by development, and changes in response to various types of abiotic stresses.
Subcellular Localization:
Nucleus speckle.
Sequence:
MSHFGRSGPPDISDTYSLLVLNITFRTTADDLYPLFAKYGKVVDVFIPRDRRTGDSRGFAFVRYKYKDEAHKAVERLDGRVVDGREITVQFAKYGPNAEKISKGRVVEPPPKSRRSRSRSPRRSRSPRRSRSPPRRRSPRRSRSPRRRSRDDYREKDYRKRSRSRSYDRRERHEEKDRDHRRRTRSRSASPDEKRRVRGRYDNESRSHSRSLSASPARRSPRSSSPQKTSPAREVSPDKRSNERSPSPRRSLSPRSPALQKASPSKEMSPERRSNERSPSPGSPAPLRKVDAASRSQSPYAAE
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASQAGGPSDSLSALRTSKLSTVVLDNHSSSGISSNIRLHPLPILNISEHLVRTRLQSEDAQLTVYGVLLGTQQGRDIDIQNSFEIRLDAASSTSLAPIINHAFLRSRQAQYKQVFPTLDLLGWYTVGEVPTPQDLEVHKQLLAYNETPLLVQLHQTVASFENAEANGELPIRVYESVVELVQGETTNFFVPAGYKIETGEAERIAVDYASKAGAESGGDHDSMLAGMQAQHSAITKLNDRIRQVLTYLEAVKDGQAGWDHQALRQIQTVVANLPQTVLPELQEELLREHNDVLLTNYLSVLTESLHTMNELSDKFEVVQAAGKEDGVNAGILGTSKSGAQGRRGGPVLRSVYG
The following text describes a protein:
Function:
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting further deposition of H3K9me3.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to chromatin.
Sequence:
MEENKSVAEGKAATGSLKESEETSAQNGELGEPEVQQTLKRTNSTESGGTGQKPPEEAPRRRFQIPRKSRDKRALQVISSGSREFEEILKILHSSYLDANSKASFSYKCARLVHNEFLEKEFTEKRRQLKFDGRLDKELVESYVFLLVDQEQMHSITEKGLHVGHSRMTTLGKPSMGVYLSRYADLLQANPLETGTTGDIFIFKVIKGKMKFVFDHIRNNQMDSFSGNGGLDPVPKHECHVLKNMNAVTALLGYRAFERTQYYFYEYGFDEVLKRPRHVCPYAVMSFGYKDELATRQPPLPTSGPVSFPTERSFDRSSFTLWRGQLLNKGKLLCYASLKSTSGPFIPYRLPERLDLDIVIKIEVIKKSIPAVLFYKETHNKPNEAKHGGIYSRLYEVVEKTRTGSHLQGLLQKIERENLALVKPLDDRGFMFLYFPSPMTSAYASAKTRLLHALFIYHESRLTQPVANVPVPPSFVPESHEFMPEVLTFVPALHFALHKSQSDTSADFNDVVEKHSRIYLKRRAEKLNKFKEYVLKPYDSRLDYKKSLYVAPRIKGHIESALRSYLFGSEAYTIPVDKAKEMLKENQRFQQFSPVSDYEPVEDDHDSNKYNKKCPVSYVETNSEKSSESTDWDIDKINGLINLIQKKKQSKPETDEPSGVGLKRKLDRQSEKAWKHRKCEENVHHDNEPGESAQSLISSLGGQDTDLRQETESLSSECIKMLLEKLADSCIDPAMAESLKTLKQNSTEELPSQKLKNLSQAHDTEREGAGQDQHIVYNDQTTDNQENTTCLSEEAQQAEGSHSDHSVLMEEKILDPPLESASPCPSNTAGNNCPAQGPNSLDLEMHWKLIPIAEANLTEEQLVYVSTEDALPNDPRAGHKRRGSRYSPLHETERQRPRHDRDYCRSLTTPSRTERNMLQSKHCHNGLIENTVLEVYNTFSEQLHDVLKQRDVPYMVPAAPPLLSSDDRVLKLSDCLCEQVSDICVQQYVDDLHTTLDSVVAAHINSCAVSRTGSPVTEIMAATEVHTFHPKQTVTEYPHVHEHFHVNDLHSDVREANPFSADHVYKVGEENAANGHALSHNSRDLSQETPEISTSGVTDLSEPHLAISNLINQMNPEVFNNLVKIITHVNKNSVKFYVHTEEENAICQNIKEYLLKLGNTECRPEKFLESKTKADKLLIIIQNEDIPNCIHRVPALVLLKRLPSVSFAGVDSLDDLKNHTYNEIFVSGGFIVSDESVLNPETVTIDELKKFLMFLEEINSPDANWQWKIHYKFHKRLKELGRLNTNALNILTLLTTYQKKNLVEILSYHLSCDPQNQQAPQLECLIKLQVQYMKQRHVLFLTEKDAARFPDYCDNGIVVTRMVDFMDNFSNLIGHHSPNNEEQRLSQLTNQGDETAPGEADSKEEEDMSLDSEDDTPPIEVCTDSWKPESQKQNISSLLELVDKDQTESPSTLNQGKTPTLDELQPITPVSVAGSTTGENSVSTGDELGSNTKDYNREVNLSHQFSHFSLLTHQTFLGSMYPTLTNPSQAEICFMNSYSQLTEPETSKNSERKQK
The following text describes a protein:
Function:
Member of the two-component regulatory system TcrY/TcrX. Activates TcrX by phosphorylation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MGITAATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNYIRSGPGPRFLDAPGQPAGMVAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPSTEVGQLGSALNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTELTQRIGDDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHVVLQVIDNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTITVSSSPGYTEFAVRLPLDGWQPLESSPR
The following text describes a protein:
Function:
Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKMLRDPLFWLIALFVALIFWLPYSQPLFAALFPQLPRPVYQQESFAALALAHFWLVGISSLFAVIIGTGAGIAVTRPWGAEFRPLVETIAAVGQTFPPVAVLAIAVPVIGFGLQPAIIALILYGVLPVLQATLAGLGAIDASVTEVAKGMGMSRGQRVRKVELPLAAPVILAGVRTSVIINIGTATIASTVGASTLGTPIIIGLSGFNTAYVIQGALLVALAAIIADRLFERLVQALSQHAK
The following text describes a protein:
Function:
Probable UDP-glucose transmembrane transporter involved in UDP-glucose transport from the cytosol to the lumen of synaptic vesicles. It is involved in platelet dense granules maturation; Alternatively, could function as a molecular adapter enhancing the formation of the PI3KC3-C1/AIC/autophagy initiation complex to promote autophagy in dopaminergic neurons. Could also regulate the plasma membrane localization of the D(1A) dopamine receptor/DRD1 and dopamine signaling.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Active at early endosome membrane in the biosynthesis of mature platelet-dense granules.
Sequence:
MRQLCRGRVLGISVAIAHGVFSGSLNILLKFLISRYQFSFLTLVQCLTSSTAALSLELLRRLGLIAVPPFGLSLARSFAGVAVLSTLQSSLTLWSLRGLSLPMYVVFKRCLPLVTMLIGVLVLKNGAPSPGVLAAVLITTCGAALAGAGDLTGDPIGYVTGVLAVLVHAAYLVLIQKASADTEHGPLTAQYVIAVSATPLLVICSFASTDSIHAWTFPGWKDPAMVSIFVACILIGCAMNFTTLHCTYINSAVTTSFVGVVKSIATITVGMVAFSDVEPTSLFIAGVVVNTLGSIIYCVAKFLETRRQSNYEDLESQAEGEERQPSGDQLPFVMEELPAKSGNSEPESAEGAGDSVQQGGQESRGSIRGISLAARSSRAEGHSDEVGRRSLKDTYLEVWRLVRGTKYMKKDYLMENEALPSP
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MYQLEKLHSDNQKFLKEHPDLPKLNKCLQRKIAIVTCMDTRLVSFVEDAIGVKRGEATVIKAAGNGVWTTGLSDTVVSLLVSIYELGAKEIFVIGHEACGMTHATSDSLSLAMIKAGVKVQDIEKVKGDLSHWVDEFKDPVDNVKKTVQKLRENPLITKNIPIHGLVINPDTGKLTTIVNGYNK
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MENGSRSKRDEEFDWLFISQNPTNSFQPSPATVNGGSGSSAMGSTSSMRPVNHNDGFLVDHGVLSFQNKQQQQQQQHQQLPAAMGVNPVRSILNHRDRYPPLLPDFIEYNPYEYDHSCNSCDQLYCAGDIIPGFPSYGYRSPLSGFPETQYDRNLEIDFSRFNISSPNHHQIPPYLPSPSTLPASDIRNNSFVYTQLRAPVTRNNTGCNDICCNPHRRDQNHSLVVENTNRSRDWISAYELQNPNNNNPFSRQQESRRPRFPASLKDMRGLIYLVAKDQEGCQFLQNKCEEGKSEEVEMIFNEIKDHIRELMVDASMNYLAQKLFKAINERQLTHIVVTLISDNGNLTSICLNSHGTRAMQKLIELLTTSEQRSLIVSALKRITVTLSKNTNGHHVIQNCLKLFHVNECQPILDVVADNCIDIATDKSGCCVLQQCVSLAVGVTKDRLISPIIENSLHLSEHPYGNYVVQHILGMQIPEATGEILRRLSGNFVSLGMNKFASNVVEKFLKDASDDVVIAINREFINSHNFLSLITHPFGNYVAQSALHTAKDGILETMINKIQKEYASLHSHPHGKRVLALARSSRPKVPGHQ
The following text describes a protein:
Function:
Nonprocessive beta-mannosyltransferase that catalyzes the transfer of a mannose residue from GDP-mannose to glucuronic acid-beta-1,2-mannose-alpha-1,3-glucose-beta-1,4-glucose-PP-polyisoprenyl to form the lipid-linked pentasaccharide repeating unit of xanthan, Man-GlcA-Man-Glc(2)-PP-Pol. Is involved in the biosynthesis of the exopolysaccharide xanthan. To a lesser extent, can also use ADP-Man and even GDP-Glc as sugar donor substrates in vitro. Is unable to transfer a Man residue to the free-tetrasaccharide GlcA-Man-Glc(2) used as an acceptor, which indicates that the diphosphate group and the lipid moiety in the acceptor substrate are of major importance for acceptor binding and catalysis.
Subcellular Localization:
Cell inner membrane. Note=Monotopic integral membrane protein, mostly cytoplasmic.
Sequence:
MSASASLPVTRAAAAPRITVLFSTEKPNANTNPYLTQLYDALPDAVQPRFFSMREALLSRYDVLHLHWPEYLLRHPSKMGTLAKQACAALLLMKLQLTGTPVVRTLHNLAPHEDRGWRERALLRWIDQLTRRWIRINATTPVRPPFTDTILHGHYRDWFATMEQSTTLPGRLLHFGLIRPYKGVEVLLDVMRDVQDPRLSLRIVGNPATPXMRTLVETACAQDARISALLAYVEEPVLAREVSACELVVLPYKQMHNSGTLLLALSLARPVLAPWSESNAAIADEVGPGWVFLYEGEFDAALLSGMLDQVRAAPRGPAPDLSQRDWPRIGQLHYRTYLEALGKDGDAAL
The following text describes a protein:
Function:
Required for ribosomal RNA processing.
Miscellaneous:
MISCELLANEOUS: Present with 6620 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKIKTIKRSADDYVPVKSTQESQMPRNLNPELHPFERAREYTKALNATKLERMFAKPFVGQLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTREKNKLEYDEKLKERFRHMPEIKRISRHRHVPQVIKKAQEIKNIELSSIKRREANERRTRKDMPYISERKKQIVGTVHKYEDSGRDRKRRKEDDKRDTQEK
The following text describes a protein:
Function:
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide. Can catalyze the reduction of a variety of substrates in vitro, including dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase.
Subcellular Localization:
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Sequence:
MKKNQFLKESDVTAESVFFMKRRQVLKALGISATALSLPHAAHADLLSWFKGNDRPPAPAGKALEFSKPAAWQNNLPLTPADKVSGYNNFYEFGLDKADPAANAGSLKTDPWTLKISGEVAKPLTLDHDDLTRRFPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAKYVAFETIYAPEQMPGQQDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLAAPDEYGFYANVNPYVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYAAQVASLYRGLDLRENF
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) complex. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells.
Subcellular Localization:
Nucleus.
Sequence:
MTPATAEVKVGGRKRKNDEPVFIKTKQSRSARREEEKENLLNKSLPSTPTSSEAGSSRESSNPVTSSSRRKNPPTKLENIQKTLPTCSDGLEIRNYVKKYGLPEDNKFLVRNVFDKQLLFGKKYVCRRRVIKSIDEFFPRLKTDAHRENGLYNFCTLQFMKISSWGSSMDEKIYVTSAAIVQSYVIIVDDNDSVTCIENGISVIPMANRTLPSISYNSSNVKNITLTGPELKKAKNVYLAVIVKRKTPKLGENRVGTRGKSTRASFETAASSENFQQLVRFGCTLMYDKDAEINCLNDGVQRIILLDREEKPAYLKIFGKADEPELENAWMNNVKHLEFISDTNYNKEDSHLARLIFSSNTHNYFDRPDISKFSPWQPRSRRTTLKSGISVEPGTSCDEDCGSQYEDTITLKQLLLGTKKLCGRRKRHLTRLTSRWPCFSVDPTKINSYFNETGVTLLENSCSYRPGTQRSIPIKPTRVIRVREETPVSVPIEVITIEDDSDDSPCFSARNRAPGGTRKYGLDFIQSSGHMPYIRYVYMNRANDLVPQLNGEENGKIEGLMEAYPMNNAHMYSDIEFLRKEKLNLPKNAQKYGEMTILDYPLTKTETDEYNKKMSVMNVKDFAVKPRKPIPTVGNTTLSLDLEGCPISTFSEIFFPSGKTELFNILCRHFYSEAGQRPGCFSAQWKSRVLTGFINKYHQYIFDMKLNSLFEKQINLIAMVSPDWKLEDFELPMVRYKQLKKEWKNRQRDIPSSN
The following text describes a protein:
Function:
Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
Sequence:
MKTSSTALLLLLSATAHGQECQDDGMEKIRLGLEWFTNPDHLPLVVAQRHGIFNSVGINVELVEPSDHWEAEEEIIQGRLDVAVTEPLHLAQDAARGKPVLGFSRFLHTDGGVLYDAGKGDIKRPADMCGKTISYPGSPGPGGPAIVNTMVKADGKLDCDLESYGKHNGGFFHTDAIQSGKADVATLVFWNFEIPEARERGMKDAAFFSLKEWGVPDFCQLVLFTTPQHFEERKDVFRKLILAMRRATGIIHQNPELARQYYYEHVKMSEAEETQKAVIDATFTATLPAFPNDNNMSNEYYEHLMSWLVDTKQVDAEKASNVSVSTYWTNEVSW
The following text describes a protein:
Function:
Intercellular signal essential for a variety of patterning events during development.
Subcellular Localization:
Secreted.
Sequence:
MCSMWLMASWLMAFVAGSTLADYCGDHKVPFGMEVHKNGNVNILCSRPSCHEKKYAECPERATSTTCSTNSSWVGGVTQHSDGSLRLMCCEYDLLPTYSTIQYEKLTIRTGEYFEGDEQMEGDVVTAFDLIGNIEQVKEPDGKYSYNLLIYRYHCGNIPDTPPAWYMKKQWPYWEK
The following text describes a protein:
Function:
Involved in endocytosis and clathrin cage assembly.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRNYEKLVKGATKLKLAPPKAKYVEPLLAGLRHTDDLRSIMSCISRRLDDSAYSVVFKSHILLHIMIREGPPNSVLKYLKRHPNMLDCQGIRRQRGGGLDGGSEASVEGLLRYNNYLQVRALRFDEQKGDYVRPKYLHRDDDLKFLSVEKGLLKECQSILDQLLALLKCRYYEEELNEDTLLTAFRLLVEDVLVLYETLNQGVINVLEHYFEMSRYDAEKALKIYQKFVKITSQVVSYLKTAKQMEYATKIHVPNIKHAPTSLADSLEDYLNDPDFDLIRRQYLAEKEARETEKRGNGYRKSSDATVRGSGVDRTASQRRSVSQPSPSEAAAAQQIQQQALQQQQQQYQQQQFQQPTQMQQPLVDLFGPSGIQMQETSIQMDTQAAILQQQQQQAQQQAALQQQQAQQQAMAQQQAQQQAQQQAMAQQQAQQQALAQQQAQQQAQQQAQQQAQQQQQQQFGHNPWGPPQQPQQQMFQQQPQQQQQNTIIPVQQQQPLLQQQTTGSNPFRKSMLQQPMQQQPMQQQPMHQQPMQQQPMQQQNMQQQHTGGHNPFGSLSRAPSTSSTLYSISEPTTTPTSPAMTAPNASVAASPASVASSSASMPAGHLIQQTTGTNPFASGGMAVSQAPMMQQNNGFGQQQQQPLVQQLTQQTTGYNPFRKSMAQQQFQTPMYNPSFGGLEQLQTNPVFPQTQHAQQQQQQQQQFGF
The following text describes a protein:
Function:
Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDMMVSEMQQPPKSPVEVPVVTKRPPAKPAKKAKRATVYFEVEILDAKTREKLCFLDKVEPHATIADIKNMFTKSHPQWYPARQSLRLDPKGRSLKDEDILQNLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLVIYLLFYFRVPFIYGPKYDFITSRHSVVHLACICHSFHYIKRLLETLFVHRFSHGTMPFRNIFKNCMYYWGFAAWMAYYINHPLYTPPTYGEDQVKLAVIIFLFCQLGNFSIHIALRNLRPAGSKTRKIPFPTRNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCFPVALFSLVGFIQMTIWAKGKHRSYLKEFRDYPPLRSPIVPFFL
The following text describes a protein:
Function:
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to chromosomes during meiotic prometaphase I and metaphase I. Upon cleavage at the onset of anaphase I, the C-terminus remains localized to chromosomes. The cleaved form transiently associates with chromosome but not centromeres during embryonic mitosis.
Sequence:
MYHHDSGPHIEEVFDPPSRRTMMQEIETHPDVIAFGKKLRKIKNQPESTFLSSADRMEEIIDAFRDQIAKWEEEEELNEPCEYRQLKIEIFTQKKIEYQRKNNLAVDEFYKKRNLKNHSNRKPLEESRRREEPRDRVHESNIDITHRGDSTSLNHYSRHHYSQRQSQSSRFERERESDEEEENSQPIQRYRSRSPKPSYSYNQSTMQQSQRDDTNVYHRSHQSTSQPPQVRMRSGKSRVTKTHNRKFRPGQKALAEIRKYQKSTDMLIQKAPFVRLVHEIIREQTYKSQDYRIRADALMALQEAAEAFMVEMFEGSVLICNHAKRVTLMPTDIQLYRRLCLRNLS
The following text describes a protein:
Function:
Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MVPIPSAELRTSYSLYSLEFDPEDANRLIVAGGGGPGNHGVGNKITAIDASRPDTLDIVSEIELSRDEDSVATLVVGPRNKDSILLYAGVNSSAEDVAKGKNEHFRVFSLDQPSKAKASSEKPNITELSRTSLFATTEKDTYQRVLRLSAPFPGSAQVGAVATGFSKEPEIALFDVPNMGAATPKLRGNLELVKEAVDMDIIQTGDDSYQLAYCDEYEMRTMNIGKGISEGPKLVFTMPDEAAVTGNARPSFRSVRYLTPDFLLAVANLPKGGGVVLHGFRMPKNDKIHNKLKEKEEEEAKKGNGSADGTVTTEGGAKGTADETVVARKVEEPKARLCISAKLPSSVTRATGLAVRNLSPPASPTAKQGDAQFVIAVTGQDSSITIYTLDHQSVADINLIVNLFKVTTFKNVHNGPISGVAFSYVVPPADSNSDEKAVAKKGSVRPEYVKLASIGSVGNSCIVHSLPLKKFVDKTAQTRRGGAPRAARYVLALKSQAPSPKGLLFFTALITLFIGIFVQSFLEIKGYSSPMIGARRFAPVSWQQNPRYGAGQGVVGNVNYANSESLNSDGVHGFLASLLADKDLKVQDGQAKKLILNVGAKDGIVQVSGHDAEVDSTAPTPKEWDELHETQKKAWKEKLKAAGHWGEGMGETIFKNILFGELGAVVGGLVR
The following text describes a protein:
Function:
Negative regulator of flowering controlling the H4K5 acetylation levels in the FLC and FT chromatin. Positively regulates FLC expression. Component of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of a NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MESDIEILSEADASMRKLRIFGIDDREDENGRRRIKDVEVYVPIVCGSIAFYLGKKATEYRTHKWTVYVRGATNEDLGVVIKRVIFHLHPSFNNPTRVVDAPPFALSECGWGEFKIDITVFFHTDVCEKKLELSHVLKLNPENAYGPIPKSIKIPVVAESYNEVVFPDPFESFVARVHNHPAIQISNIPDGLNLPPPGVADTYYLMEKGDTKEHPLSPWFLKFSEVEELFKLTAARQKVQADIAKLKRQLIMVDGQPEGLESSSGYEC
The following text describes a protein:
Function:
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Also acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MTTLDDKLLGEKLQYYYSTSEDEDSDHEDKDRGRGAPASSSTPAEAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMSCRSHLDEEEEQQKQKDLQEKISGKMTLKECGMMDKNLDDEEFLQQYRKQRMDEMRQQLHKGPQFKQVLEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLAAEYPTVKFCRVRSSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVDTSSSAPASASPAITTSAAATTPVVILVVGMAGTGKTTLVHRMQHYAHTNGIRSYFINLDPAVTHTPYNVNIDIRDSVRYGEVMKNYRLGPNGAIMTSLNLFATKIHQVVSLLEKKEEMLDWIIVDTPGQIEVFTWSASGQLMADSFGAVFPTVLLFVADTVRCVSSPQTFVSTMLYSSGIMLKQQVPLVVVFNKTDVVSADSVIAWMRDNDALDEAVTNPHRSNRSRRAVSGEPGDGEDADWRGEGTRIGAAALGSQDALLANQGSGYAGTLAQSMSLFLHEFYEDLPYAAVSAASGAGMSELAASIERGKQQALEAKAERSAH