lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts.
Miscellaneous:
MISCELLANEOUS: Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex; MISCELLANEOUS: Two proviruses inserted as tandem repeats in most of individuals tested. Both proviral genomes encode identical Rec proteins; MISCELLANEOUS: This Rec protein is encoded by a human specific provirus; MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HML-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus.
Sequence:
MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGVPNSSEETATIENGP
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSTANFFDTAAELGSEEEDEDFDEEGGEVRPKKTNGANGLEDSSEEEDEDDDELLAQEGAGFVVDEDEEDEEAERKRRRKKKRKNREVDEALDDEDLDLIGVEVERPDETQSRFKRLKRGHKERARARGIDDIFSDDEPNDDIDEPRRAGLNEFDDFIEDDQFEDEIEDDRDVTQPGINLITQGLQAAGLDEGAEEDYRAAFGDGTDYDWALDMQEAEEDEQAGEGRDLQLKDVFEPSQLQERLLTDDDNIIRETDVPERLQLARKPFKDLELTDEDMQERLKEEAHWITTLLWPKKGLEGYFHAPFERAVHKVLEFLNIEDYEVPFIFNHRKDYLIHAPGDSDDQDDANLPPVNVRPERLLNQSDLWEVFDLDLKFRAFAEKRDALRLNYDNIRSVYPEIIDTEIEDLSNKAITIEEIQELQDYLHYRYSTEISEVRQETNGVQKRANNARSFYDKLRSGKAHQLVKAIGITAEDFAKAAEGTSRGAQIIEDPPFQVQEYADQLAEAPETGTTLLRSAKILFVQDLNMSSRLRRFLRGSFYQNAQIDCIRTDKGARKITEDHPYYEFKYLRRQTFMDLHGRPDLFLKMLKAESEGLVQVQISMSNYTDFKKRLQGKIVSDNVSEVSDSWNNLRRELLDEALDKLQKVIAAGVKESLRARCEDELASRARESYYNRLDQAPYKLKAAPLGSVPNALCMSNGQGQRGDAIMWAYVENDGRVLEHGKFVDFRLGNQERGIADGQDIAKFVEAAQRRRPDVIGISGWSVETRKLYKDVQEIIQQNGLTGPTYEDENSGQERSDPLEVVLVNDEVARLYYNSGRAAAEFPKYAPLVRYCISLARYLQNPLAEYASLGKDIISIPFIPNQTLIPQEKLFDRLETAMVDMVNLVGIDLPESYDDKYLGKLLPYVCGLGPRKADRLVKAIQANGDEILSRYDLLGVSENSSRDLKAAMGPKVHQNCASFLYIPYDATEESSDYLDYTRVHPEDYDLARKMVADALNMDEEDVKAETDEGGPSAVIRKMVREETTDLVNDLALEDYAIEIQRNFGQRKRATLETIRAELENPYEEIRQTFALMSSDEIFTMLTGETKETLYEHMVVPVTIKRTFPDHIECRLECGIEGGVSESEFPEGVGNGGQEPRHVYQSHQVVRGRIMFLNIKALTAQLSLREDIIRKPQPQPDRIPGEWDDLQEAADKKAAEKEKEVASGRPNRVVNHPLFFSFNSIQAEEYLGSKEVGELVIRPSSKGFDHLVVTWKVGNNAYQHLDVLEMNKPNQFTLGKQLKIGKTTYTDLDELIVNHIEAMARKVSELTRDERFKTGTKEETEQWLENYCTANPNRSMYAFCSMPKYPGHFWLCFQLGHEKPKGAWPFKISPGKFEMRGHAYGDMVSLKNGFKMLARVAGTGAAAGGAIPRR
The following text describes a protein:
Function:
Phosphorylates elongation factor-2 (eEF-2) at two threonine residues that are conserved in all eukaryotes and are located within a GTP-binding domain. Calcium(2+)/calmodulin dependent activity. Inactivates eEF-2 by catalyzing its phosphorylation. eEF-2 catalyzes the movement of the ribosome along mRNA during translation in eukaryotic cells.
Sequence:
MTIDTTNESDNSPTNSPGLEASARTFSLNASKMVRITDDYADEVFIEQNDVVIEKPRMDPLHVRKLMETWRKAARRARTNYIDPWDEFNIHEYPVQRAKRYRYSAIRKQWTEDIVDVRLHPDSFARGAMRECYRLKKCSKHGTSQDWSSNYVAKRYICQVDRRVLFDDVRLQMDAKLWAEEYNRYNPPKKIDIVQMCVIEMIDVKGSPLYHLEHFIEGKYIKYNSNSGFVSNAARLTPQAFSHFTFERSGHQMMVVDIQGVGDLYTDPQIHTVVGTDYGDGNLGTRGMALFFHSHRCNDICETMDLSNFELSPPEIEATEVAMEVAAKQKKSCIVPPTVFEARRNRISSECVHVEHGISMDQLRKRKTLNQSSTDLSAKSHNEDCVCPECIPVVEQLCEPCSEDEEDEEEDYPRSEKSGNSQKSRRSRMSISTRSSGDESASRPRKCGFVDLNSLRQRHDSFRSSVGTYSMNSSRQTRDTEKDEFWKVLRKQSVPANILSLQLQQMAANLENDEDVPQVTGHQFSVLGQIHIDLSRYHELGRFVEVDSEHKEMLEGSENDARVPIKYDKQSAIFHLDIARKCGILEAVLTSAHIVLGLPHELLKEVTVDDLFPNGFGEQENGIRADKGQKPCDLEEFGSDLMEIAAEMGDKGAMLYMAHAYETGQHLGPNRRTDYKKSIDWYQRVVGFQEEEELDSDCGKTTFSSFAPLTRHEILAKMAEMYKEGGYGLNQDFERAYGLFNEAAEAAMEAMNGKLANKYYEKAEMCGE
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MHSQRLVSDPRVGATASGTVGADADLSGGGSSIGGTPQLSLIESLRGRAVFITGATGYLGGVVLEQLLRVAGEAVGRVYVLARARGRLGAAERVGRVLGGGLFTTVRERHGEAMRKVVAVAGDLSESGCGISEAALAEMAAEGSLLVIHSAARIALEDPIQTTLLNNYEGTRRLLGLVAGRLAHCCAGFVHVSTSFVGMNQPHNSVVPERLCPLMFGDQRVDHARLARELLATDTAMADMRADMLCKNWGLPNTYLLGKHLSESLVEQYHSERLIPAGCAIVRPSLVSALAGAPWPGYVGNLAGPSGYMTAFALGFFNRGSAAWHAWHLLDSVPGDVAGAVILAAAAALAAGIHSREQLHALAARAAANGGGGGGGAAAVVAATAAMSDQRTSGSFLEGGNESFRLRPGVQGGGGFGGALRTITTVGRAHDGGAEGGGGGGGGAAATLAEDSGDHWNRRALQAQAALDAAAAGEEGRREAPAAQRAAGELLVFHAASSTVNPCLHWEAYEMARRFFTVHKLKYRLGGYVRAGADYMPVPWRVTLAKKITKAKVAAAAGLLGCFGQQRAARKLRVGFTAWDYANDVKHDKTLFFSVRNVLALERCLPPQERAALPLVWRGSWELFANTYMAGVCKLFMGLPVPPATPQLPHNFVHLPFVHLTPEQLPRVAGAGAAAGTAAAGGPAGTTPTAAAVPPTAAGTTAGAGAAAAAAAPLAVEEQTRTAAAAPPAGAGEGGGGGGSAVNGSSGGGGGKKGGPWTLGKILGGGGDGGGHKKHDTATDQEQQGQGPALVKAGGVAAAAPAGPAQALPAQVV
The following text describes a protein:
Function:
Transcriptional activator that binds specific DNA sequence. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. May directly activate some type-A response regulators in response to cytokinins (By similarity). Functions as a response regulator in response to cytokinins.
Subcellular Localization:
Nucleus.
Sequence:
MLLGALRMEERKGLMGRERDQFPVGMRVLAVDDDPVCLKVLETLLRRCQYHVTSTNQAITALKLLRENRDMFDLVISDVHMPDMDGFKLLELVGLEMDLPVIMLSVNGETKTVMKGITHGACDYLLKPVRIEELRNIWQHVVRRKFGNRERNNLDFSKECNKPQSADTDHGPYQPTCGSSDQNGRSSRKRKELHGEDDDEGDDNDYQENDEPSAAKKPRVVWSVELHRKFVAAVNQLGIDKAVPKRILELMNVEKLTRENVASHLQKYRLYLKRLGAVASQQASIVAAFGGRDPSFLHIGAFEGLQSYQPFAPSAALPSFNPHGLLTRTSAAAAFGLQELAAPSSTIQTSTGNVTVGHCLEENQQANLAQGLTAAIGQPQLQQNWIHQEGNGLSDVFSGSSLTNTLSSTLQRVPSSSLPPQELLECKQAKVSMPPSIRIPPSSSALLERTLGVSTNLGDSSISQQGALPIDGGFSADRLPLHSSFDGAVATKLDTSLAASQREIGQQGKFSVSMLVSPSDNLALAKNAKTGASSSGSTIILPLDTARHSDYLQFGGASNSLQKMDGQKQDHIQSSNIIWSSMPSTQLPSDTQIHNTQNQRLDSGSFNHNIGAHLADQTNASASILPQMKFDTRISEEKMKQKNTYDLGSSKLQGGFNSSGCNFDGLLNSIIKVEKDDLPFMDNELGCDLFPLGACI
The following text describes a protein:
Function:
Cereal endosperm protein required for the ring-shaped distribution of 22 kDa alpha- and 16 kDa gamma-zeins in protein bodies.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=In endosperm, predominantly deposited into protein bodies, at the interface between the alpha-zein-rich region and the gamma-zein-rich region.
Domain:
The seven repeat domain is responsible for dimerization.
Sequence:
MSLHAARGGPHEDLSWSAIGRRAPRDVVTFGDREGGGGMRSAQQGPGAVRVDEASSASTFRELDEAFLQTQTKIWLGEVLHLRFGEDALVADLLADGELLFQVSKVLWKMLLKNNREQLKQSKVYIYERLSFGRSSGKYMPYSKVDSFLKICQILGLAGIDLFTPSDVVEKRNVRKVCICIRSVSKKSLILHLNVPDFDVVTYTISMPNYVVGGIRRNLEQTQYSSSSSSGYSPCARSKVLQQQIIFGGQNDQHEDTHYDSDEAESKLSLLEPEDSVNEDNFAAVLSQFNDAHNKGSEGYGESGCGKHGEKSLAESVGSLNIGIIDFEFMDSTPLIHDKESCSLLEPEDSVNEDNFAAVLSKFNDAPNKESKGYGESGRGKHGEKSLAESVGSLNIGIVDSEFMDSSPLIHDKESCSPLEPEGSVNEDNFTAVLSQFNDAPNKESEGYGESGCGKHGEKSLVESVGSLNIGIVDSEFMDSSPLIHDKESCSPLEPEDSVNEDNFAAVLSQFNDAPNKESEGYGESGRGKHGEKSLAESVGSLNIGIIDSEFMDSSPLIHDKESCFPLEPEGSVNEDNFTAVLSQFNDAPNKESEGYGESGCGKHGEKSLVESVGSLNIGIVDSEFMDSSPLIHDKESCSPLEPEDSVNEDNFTAVLSQFNDAPNKESEAYGESGCGKHGENSLDESVGSLNIGVIDSEFMDSSPLIHDKESCSPLEPEDSVNEDNFAAVLSQYSDGPNEGNEGYGESGHYKHEEKSLDESVGSLTIGIIDSEFMDSSRPIHDKESCSTGSAADQCSRTIPAKYELSSEESDSTGSHLVFDSGKNYLELNNHSVTDLERIYNGHATSVDQYVRGNGETLADHPKKEEAGLQKDTGTIAQHRDTLACDGESVCSSCEEPRRGLNGEPSDFSSESHSRLTPTHNTGGKLSMVSEHPVHNMESDMTGMASDSTNPELNPEASTRNEMDGSRSTDNPVEPENVAQDSATRGRPEGDAPRSGKGVLRSVAGGITLVGAVFFMFHLSAALLQKKQGGKLCDGHTISFGKICSEQRKGQEHGQRKRP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAHVNEYYKHLKGDVGALCLVCNVACQHWNTLQRHLQTHINFRPFTCDFCGRTFFSQSKLKRHQVIHNDVKPYKCPVCDRRLGRTEHLKRHLLVHTDSKPFGCSGCSHTTKRLDGIRRHIKRKHGV
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MQTFDSLHLQLIGKTGSGVSASANTILGENRFKSERSLTSITDRCQKHTAKVWNRTVTVTDSVNFFNSNDIDLRVELERELRTRAEGIHAILLVLRLHTFTAQDAKLLSLYKQMFGESAMKHTIVLFTHGDELQHTSLSQLIRENSELSKLIEECGGRFHLLNNKDMNNKDQVTKLLVKIERMLSENENRCYTLQMFMQAQAIRIQHLCAVSVVIVLALGYVNMRNEDYWGFNSFLHGCFGGVLSALVGYASGHICANMWKNEIRKCGKCTKRHLRNVELLSVAWGCGAGGISVFLTGPVCLFTALLRGTQGSLMAYITMMKHCRLI
The following text describes a protein:
Function:
Required for maximal bacterial cellulose synthesis.
Miscellaneous:
MISCELLANEOUS: The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when DgcC, a putative transmembrane protein regulated by CsgD, is expressed. Cellulose production is abolished in E.coli K12.
Sequence:
MRKFTLNIFTLSLGLAVMPMVEAAPTAQQQLLEQVRLGEATHREDLVQQSLYRLELIDPNNPDVVAARFRSLLRQGDIDGAQKQLDRLSQLAPSSNAYKSSRTTMLLSTPDGRQALQQARLQATTGHAEEAVASYNKLFNGAPPEGDIAVEYWSTVAKIPARRGEAINQLKRINADAPGNTGLQNNLALLLFSSDRRDEGFAVLEQMAKSNAGREGASKIWYGQIKDMPVSDASVSALKKYLSIFSDGDSVAAAQSQLAEQQKQLADPAFRARAQGLAAVDSGMAGKAIPELQQAVRANPKDSEALGALGQAYSQKGDRANAVANLEKALALDPHSSNNDKWNSLLKVNRYWLAIQQGDAALKANNPDRAERLFQQARNVDNTDSYAVLGLGDVAMARKDYPAAERYYQQTLRMDSGNTNAVRGLANIYRQQSPEKAEAFIASLSASQRRSIDDIERSLQNDRLAQQAEALENQGKWAQAAALQRQRLALDPGSVWITYRLSQDLWQAGQRSQADTLMRNLAQQKSNDPEQVYAYGLYLSGHDQDRAALAHINSLPRAQWNSNIQELVNRLQSDQVLETANRLRESGKEAEAEAMLRQQPPSTRIDLTLADWAQQRRDYTAARAAYQNVLTREPANADAILGLTEVDIAAGDKAAARSQLAKLPATDNASLNTQRRVALAQAQLGDTAAAQRTFNKLIPQAKSQPPSMESAMVLRDGAKFEAQAGDPTQALETYKDAMVASGVTTTRPQDNDTFTRLTRNDEKDDWLKRGVRSDAADLYRQQDLNVTLEHDYWGSSGTGGYSDLKAHTTMLQVDAPYSDGRMFFRSDFVNMNVGSFSTNADGKWDDNWGTCTLQDCSGNRSQSDSGASVAVGWRNDVWSWDIGTTPMGFNVVDVVGGISYSDDIGPLGYTVNAHRRPISSSLLAFGGQKDSPSNTGKKWGGVRADGVGLSLSYDKGEANGVWASLSGDQLTGKNVEDNWRVRWMTGYYYKVINQNNRRVTIGLNNMIWHYDKDLSGYSLGQGGYYSPQEYLSFAIPVMWRERTENWSWELGASGSWSHSRTKTMPRYPLMNLIPTDWQEEAARQSNDGGSSQGFGYTARALLERRVTSNWFVGTAIDIQQAKDYAPSHFLLYVRYSAAGWQGDMDLPPQPLIPYADW
The following text describes a protein:
Function:
Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Golgi apparatus. Presynapse.
Sequence:
MSSMQNAMNFLKRRFSDTNFNSNLPNGYLESDDDVSVTSSVSRGTPQKQQIAQPGINQQNKTNVNPAQSGQVSSTGGFFASLASGNPLAVLKVDGNEQIKTVLVVDEQHTDWSKYLKGRKIHNDYTVRVEQAEFSELSLSSHSVNGVTVDINCYRNGNKVVRSFKPDFLLVRQTPRSMAQGEDFRNLVIGLKYGGIPSVNSLHSQFNFMDKPWTFSQLIRIQKRLGPEKFPLVEQTYYPSHKQMLTSSHFPVVLKIGHAHRGMAKFKVENHYEFQDVVSVAALTNAYVVSETFIDSAYDIRVQKIGGNYKSYIRTSISKNWKANTGSAMLEETPVTERHKLWVDACSEMFGGLDIVAVKAVHGKDGRDYIIEVVDCSMPLIGERQEEDRRMISDLVMQRMTACTRPRPDHTPSTAASVYGRSYSSQNTSREMTPQRNVQVPQNRPNHAIPSCPPSAPLSSHSSEPPSPTATRRSNSVSEPSSPGGDRERIRSTTVSEDEESKAEKIRSLRQSFANLFSD
The following text describes a protein:
Function:
Golgi apparatus protein involved in N-glycan mannosylphosphorylation. While MNN4 seems to have a regulatory role in N-glycan mannosylphosphorylation, a transferase activity of MNN4 can not be ruled out. Mediates mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides. Has partially redundant function with MNN14.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum exit to the Golgi apparatus requires SVP26 and MNN6.
Domain:
The conserved DXD motif is essential for the function, which could be an indication that MNN4 has transferase activity.
Sequence:
MLQRISSKLHRRFLSGLLRVKHYPLRRILLPLILLQIIIITFIWSNSPQRNGLGRDADYLLPNYNELDSDDDSWYSILTSSFKNDRKIQFAKTLYENLKFGTNPKWVNEYTLQNDLLSVKMGPRKGSKLESVDELKFYDFDPRLTWSVVLNHLQNNDADQPEKLPFSWYDWTTFHELNKLISIDKTVLPCNFLFQSAFDKESLEAIETELGEPLFLYERPKYAQKLWYKAARNQDRIKDSKELKKHCSKLFTPDGHGSPKGLRFNTQFQIKELYDKVRPEVYQLQARNYILTTQSHPLSISIIESDNSTYQVPLQTEKSKNLVQSGLLQEYINDNINSTNKRKKNKQDVEFNHNRLFQEFVNNDQVNSLYKLEIEETDKFTFDKDLVYLSPSDFKFDASKKIEELEEQKKLYPDKFSAHNENYLNSLKNSVKTSPALQRKFFYEAGAVKQYKGMGFHRDKRFFNVDTLINDKQEYQARLNSMIRTFQKFTKANGIISWLSHGTLYGYLYNGMAFPWDNDFDLQMPIKHLQLLSQYFNQSLILEDPRQGNGRYFLDVSDSLTVRINGNGKNNIDARFIDVDTGLYIDITGLASTSAPSRDYLNSYIEERLQEEHLDINNIPESNGETATLPDKVDDGLVNMATLNITELRDYITSDENKNHKRVPTDTDLKDLLKKELEELPKSKTIENKLNPKQRYFLNEKLKLYNCRNNHFNSFEELSPLINTVFHGVPALIPHRHTYCLHNEYHVPDRYAFDAYKNTAYLPEFRFWFDYDGLKKCSNINSWYPNIPSINSWNPNLLKEISSTKFESKLFDSNKVSEYSFKNLSMDDVRLIYKNIPKAGFIEVFTNLYNSFNVTAYRQKELEIQYCQNLTFIEKKKLLHQLRINVAPKLSSPAKDPFLFGYEKAMWKDLSKSMNQTTLDQVTKIVHEEYVGKIIDLSESLKYRNFSLFNITFDETGTTLDDNTEDYTPANTVEVNPVDFKSNLNFSSNSFLDLNSYGLDLFAPTLSDVNRKGIQMFDKDPIIVYEDYAYAKLLEERKRREKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKQEEEEKKKKEEEEKKKQEEGEKMKNEDEENKKNEDEEKKKNEEEEKKKQEEKNKKNEDEEKKKQEEEEKKKNEEEEKKKQEEGHSN
The following text describes a protein:
Function:
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPFNRLSLPCLLLALIASLFIHAAQAGGKIPKAVTEAYLRAEKEILHLEQSSFQTKIQKGNWMIFYGATWCGHCQKFTPTWLELQKKVETDFKDSNFHVGKVECTLNADLCEQIAGFPTVYYYQDGKRVGDEVVDQELPDLLKFVKSHAWDKSGQPGLANLKDAELNAGKPNIALDQSPMEVLHAYAEQEIHPGADVNPTGLVTHMTRGTFASLTAERSWFVMFHAPWCGHCKTLAPIWDQVAEELKGQVDIGKVNCDEEKDLMKRFNIKGFPTLVLINEPNAPIVYKGSRRLEDIKKFVLDSITRPSFLPVTAKEIPDIISKEEVAFYFAYDANVTDYIPFRMFQSVAKTVKPFAKLYVSPEVQAFKILHAEEGKPVLIAVRDGGLDSSVYPGEFAGDGSTRTMLREWIMQERFPLVTKLDTATQADILESNRFVALALVNPDTPDGKGALDHFKNSAKHWKNIAAAEKRNRVKFAWIDAKMYADYVFSVYSVKPMDLPVFIIANPAMEQYYNEFADGKKYDSFAHVVVHDSINEVLDGKGKAKTNQGTFSRSAKWVNRQFVRTVSIFVTNNIIVTVLIMGGCIMSLTYYAMNRKGGYQSVSSISKQE
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSPRSNILVPVSVSQNPKNQRRFVVVVGEERERKNKKKKVISGSQDGAGSDAPAGAERDVSNDGGGVAGSGGNQFPSTSLYVGDFQASVTETQVYDLNPVNATTALEVLNFMPLNNKPIRILDSNRDPSMHRNGAANIFVKNLDKAICNGQLFDIFSAFGRIVSCTIAKDASGQSKGYGFVQFEQEEAAQNAINEINGMLLNDKPVFVGPFIRKKERQNSLDKTKFSNVFVKNLSESTTNEDLENIFGEYGKITSAIVMREEDGKSKCFGFVNFENPDDAARAVQELNEQKFDDKEWYVGKALKKSERELALRKSYNQSARNTVDRDQGLNLYLKNLDDSVGDDELKELFSDFGTITSCKIMRNPDGISKGFGFVAFSAPEEANRALEDMKGKMVRGKPLYVAPAQRKEDRRASFQAHFSQVRPVAMGLGPSVGPRVSIYPPSAPGLGQQIFYGQPPPNLIPPQPGFRFQPQLIPGVQPAEAPMPNFLPAPVQQRRKVHQPLTLQQVLDHLACKLQLVESRKSTRMVPKFHVHSYPPGTPGAVGGMLHPNEMGGLPMQDVAVPQPIPIAALPSALANAPPEQQRLMLGDSLYALVKQLEPVDTAKVTGMLLEMDQTEVLHLLESPDALRAKVAEAMEILRSVAQQQQG
The following text describes a protein:
Function:
Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI).
Subcellular Localization:
Secreted.
Sequence:
MAWKWIKAFVYLSVCVTSALGDDEEASASKCADFNNTTWLEYRQATKLQVQYLLLTRKNANCASLFTQDCLNHTQKHTAYFNSSLPTKVIVHGYRALGSKPSWVSGLAQALLREEDVNVLVVDWVYGASFAYNLVVENYKEVAVQISVLINQLTKYGSTLESFHFIGVSLGAHVSGFVGTLFHGKLGRITGLDPAGPMFKSADPFDRLDSSDALFVEAIHTDSDYFGISIPVGHVDFFLNGGMDQAGCARSRFASMYGYVICDHMRALHVYMSALNGSCPLIGFPCSGYEEFLAGKCITCDDPFNGTCPQIGLLKNSGITATPLPNQEKVYLLTTASGPFCAHHILVELNVSRLDKTAEVQLILKSIGHPETELNLKLYTDETRYKTVAAHPEQLCKIDSMQLINTGGRFYRQGDIHFEYICISEIPQTRGMDPLCVKNIHIGRGVPWSHDFVQVC
The following text describes a protein:
Function:
Metallocarboxypeptidase inhibitor. Has an inhibitory effect on bovine CPA1 and CPB2, human CPA1, CPA2, CPA4, CPB1 and CPB2, and porcine CPB1. Does not inhibit D.melanogaster svr (carboxypeptidase D). Shows no activity against serine proteases subtilisin or bovine trypsin, cysteine protease papain, and aspartyl protease porcine pepsin.
Sequence:
FHVPDDRPCINPGRCPLVPDATCTFVCKAADNDFGYECQHVWTFEGQRVGCYA
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MAMKCKMKCFAPSVFQIRYAGYKGVVAVDPRSNRKLSLRKSMLKFQSENITLDVLAYSKYQPCFLNQQLITLLSTLGVGDSVFESKQEEAVRQLNRMLTEPQAAIEAIKLIPMGEVTNMVKELLLCGYQPDHEPYLSMLLQTFRASKLLELKTKSRIFIPQGWTMMGCLDETRTLKYGHVFIQASYCADDRHKFVVTGMVVVAKNPCLHPSDIRVLHAVDVLDLHHMFDCVVFPQQGPRPHPNECSGSDLDGDIYFVSWDQTLIPSRLVEPMDYTQQPAETLDHDVTIKEIQKYITNYIVNESLGIIANAHVVFADKEHLKAESLPCIELAKLFSIAVDFPKTGVPVQIPHELHVREYPDFMEKPNKATYGSKGVIRKLYREIKKHTPHVKYFTMDVARRSSDSDLIVDGYEDYITEAIEFKQEYDFKLGYLMDHYGIKSEAEIMSGCILKMARNFTKSCDADAIRMAVRSLRKEAMSWFSEMAMDENGVGQDDLDAKASAWYHVTYHPEYWGCYNEGYVRDRPHLISFPWCVYDRLVNIKQRRNLKRKMVLK
The following text describes a protein:
Function:
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Sequence:
MEYSTFGKHIIVDLWGVDFSLLDDMHFLEYHLVTAADYSGAHVLNVSKKEFQPYGVTVLVLLSESHLSIHTYPEQNFAAIDCYTCGTTVEPQIAIDYIVNILKPERMHIKRLIRGIGEIVTAD
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLRDELLRSKNDEIARCLLSRKRKLSELYFATVGFAGATENAPTNALYHQKEQTFLDANDLTKGRYFNEATLPPFPDFAALIPRPEEQHSSLEITEPVVQTDDVSSVIAPKAEGAVRGIAPSFQQQEGQTAQVIEQRLVEDSLKKDDARIHQQPALATTSEIPQVANSPTTPAQPDQLPQKASFAVPDTPPTSTSHESVDASVSPALKGLPPSEVAPPRAVSNQLPSAQRKPESRPSLVLAQPSEDQPLSPASSAGPYSNNTPAPVAVSPDTSPAEEVTEGADEVALSPKRVGPVQLQPGLVPSTPDEQLQLEAAQSLQQNALASKSIGDVTTASSLSNEVIKEDVGPTPSAAADSSKETQDQTSTSVEAPEPKRPDGVVVAPEESQPPAQSIQEETQSQVGAEVKVVASTTPAGKKPTAAAVLPAQPERMTTRVSSGAIRHKSVSEILGETPKPSAVQPEKAHAIEKPADMVRAPASASPESAAKMRLKDRKAREKERSKLSTVVFPKQQQQQQQQQEKDDSLDIVRQYAGELARLNEEQDYLFTLFQNKAYAPPRGTNLSTLLASAHKTLTTSNHLLEYQEQMDCRTLRRIYALQNANRWPLRQLKRSVEPPRQGTHWDVLLDHMKWMRTDYREERKWKIAAAKSCADWCAEYVNSDPEHRALLRVPCRIPSKFEKKEAHASSMISPPEETTEEMLVVSQPTPDLIPSAEDESVSDGFNDEIRHDIRDTVAPAAIFSLGSDEFTFSLDMTPAAQKLLDELPIYTPVKIAPGANVPMFEQPPDSAWKTELLPVSKYASGRIKFHETESPRKRSRYDYSQYDSNPEHGMLDLPPEQTNVALFRPENKPIRDRIHPGHSFRPPTEYPMPSVGFFESRQSSQWTYAEDDELRRLVKEYSYNWSLISSCLTPSSQFTSGAERRTPWECFERWVGLEGLPADMSKTQYFRAYHQRIETAQRTVLAQQQAAQQQQQQQQQQQQQGGNNSGQAQPPIRRRTTQPVRVDRRRSSKHLALLDAMRKLAKKRETMLQKQQHASHLASLRKVNDANQPKPPISSPAEFSRLKYDRELKLQERQEQYRQQMIAQQRANLAAQRAGQIPSQQPMMNAPPGRTPNGIPHNPGTPGIPGATPNGMHNGMPNALPNGIPPGMGVSQGRPHMQGVPAGGPPMNGPIPPNPMAMKMMPQTGMPQGPGGRPGMPMQTSPDNTRVMREANRLQEQQRILQSRQQQPQPPQHQQPQAQQAQQQFHNQQQFGPQGSHSPNMNLPNVNGTPNNPAMMAAIQAGSGMQSPSLHNAMPQGVSTPSPRMGQPNLLSGGVVPTISSIQSQIQRSNPNMPPEQVNKLATDRLHQYQQQRMSQVAMNAAAGNMASVQANYQVPHDGNFQSPQPGMNGTPGMQVPQSQGFSPMMRVPQPAQQNRMGVGNSPAMNVALPQQSRSATPQTQRSGSAQAGPVPGSSKSPHPPQAQIPSG
The following text describes a protein:
Function:
Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell projection, dendrite.
Sequence:
MSDPHSFLGCVRRGLRFDMFKDVARQYPVIFCIFTVMISSTIILNQYLHILMVFWSFLAGVITFYCSLSPEYLLPNILISIKTKRKPQEQHELFPLGHSCAVCGKNQCKRHRPTLLLENYQPWLNLKVPSKVDASISEVLELVLENFVYPWYRDITDDEACVDELRQTIRFFAAVLAHRAQRVDVPSVVMDKMMKAAMKHIEIIAKAQQKVRNTDGLEQAALAEYGADLHVALRSRKDELLYLRKLTELLFPYVMPPKATDCRSLALLIREVMTGSVFLPIMDFVADPDTVNHMVLIFIDDSPPEPVTDPPSTLVPFLERFADPRTKKSSVLKLDLKEIREQQDLLFRFMSFLKEEGAVHVLQFCLTVEEFNDRILCPDLSDDEKQRLHEEVKKIYETYCLEESIDKISFDPFIIEEIHSIAEGPYTGVVKLQTMRCLFEAYEHVLCLLEKVFTPMFCHSDEYFRHLLCGAESPARNSKLNRNTSKRGESFGISRIGSKIKGVFKSSTMEGAMLPQYAMIEGEDDTVEEAVMVFEDDSPGPMDAVGTPGTLRNLSAWTISIPYVDFYDDEVKKERIPVFCIDVERNDRKNVGHETESWSVYRKYVEFYVLESKLTEFHGPFQDAQLPSKRIIGPKNYEFLSSKRGEFEEYLQKLLHHPELSNSQLLADFLSPFSMESQFRDKMLPDVNLGKIFKSVPGKLIKEKGQNLEPFIQSFFSSCESPKPKPSRPELTILSPTAENNKKLFNELYRNNANLPEGLEKKHNQNYFMELMEVDGAYDYMMYIGRVVFRMPDWLHHLLSGVRILLKRTLEAYVGHYFQYKLEQIMEEHRLVSLVTLLRDAVFCESTEERSPEDKQRRAKQTFEEMMNYLPDIVGKCIGEEAKYDGVKMLFNTIQQPLLNKQMTYVLLDIAIQELFPELSKNQKQGLSVSTRWM
The following text describes a protein:
Function:
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
Sequence:
MASGGRHAPQNSASEVRPSRCPGKSSDESLGEMALRCPLPPRPWNVSLSAAIQRSFSEACLRDALRFPAPPSWTRSVRGGMRARPPAGPDPAAARGPSPAPSTQPPVPSAPRLMQKTWGGFPDQRRLLAYLTQAQGREARLWRGGQLQQAEICEAFREVVLWLLRVENIFDFSQTTFNLALSIFSRLIVSVKIKKHLLHCVTITSLRLATKVNEEEELIPRIKDFIKHYGSGYSPNELLRMELAILDKLHWDLYIGTPLDFLSIFHALVVLGWPHVKELMPQRNPSLHVASLTRQLQHCMAGHQLLQFKGSTLALVIITLELERLMPDCCTPISDLLKKAQVGIRQWNRCKELVKEQLASL
The following text describes a protein:
Function:
Essential for meiotic chromosome segregation. MER1 and MER2 proteins must interact directly or indirectly. MER1 might be responsible for regulating the MER2 gene and/or gene product. MER2 is not required for mitosis and mitotic DNA repair mechanisms. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to chromosomes.
Sequence:
MVARGRTDEISTDVSEANSEHSLMITETSSPFRSIFSHSGKVANAGALEESDKQILEWAGKLELESMELRENSDKLIKVLNENSKTLCKSLNKFNQLLEQDAATNGNVKTLIKDLASQIENQLDKVSTAMLSKGDEKKTKSDSSYRQVLVEEISRYNSKITRHVTNKQHETEKSMRCTQEMLFNVGSQLEDVHKVLLSLSKDMHSLQTRQTALEMAFREKADHAYDRPDVSLNGTTLLHDMDEAHDKQRKKSVPPPRMMVTRSMKRRRSSSPTLSTSQNHNSEDNDDASHRLKRAARTIIPWEELRPDTLESEL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MISPAKINLGLEIPFKRLDGFHEIRSVFLKISWGDDIEIEPASNGVFELFSNNEIILEKRKLYDQVSERGDIKNNILYKTFIKARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLLNFLFSWRPFFTSDEMFVLAAEIGSDVPFFLGEGHAFVTGKGEILEEIEVHHGQGILALTPQVMNTSEMYSLLKKPLQESASQKNGNTLSKNLISILKNGDWSSLQGRLWNDFEPVAFQLHPELGVLKDKFLEFGSSYCSLTGSGSSMYGLVQGLEIQEELLQRLRQEFSNLTFVRFNF