lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of P-granules which is required for P-granule formation and integrity in adult germ cells. Promotes the accumulation of glh-1 mRNA and localization of pgl-1 to P-granules. Involved in RNA-mediated gene silencing (RNAi) in the germline. In particular, it is required for piwi-interacting RNA (piRNA) gene silencing and positively regulates the formation of secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. Its role in RNAi may also be through positively regulating the expression of the dsRNA-binding protein rde-4. Plays a role in small RNA-directed transgenerational epigenetic inheritance.
Subcellular Localization:
Cytoplasmic granule. Cytoplasm, perinuclear region. Note=Localizes to P-granules in germ cells at all stages of development. Co-localizes with prg-1 at peri-nuclear P-granules in the proliferative zone and transition zone, at pachytene, in oocytes and in embryos. In the distal loop, a higher proportion of deps-1 than prg-1 dissociates from the perinuclear region. In the adult germline, co-localizes with znfx-1 at P-granules and with pgl-1 at P-granules in the pachytene region.
Sequence:
MSERQSKYFDYQGIVISSTGQDNQDSETDLVYLIQAHGKAAPKNIMYGVSKCAFVPTNLERNFDNIEEAKNLERRSKIPLKFGEVILWNESDCDHDKRIILHIKREKPIYEASSSRNGLILKVGGVIQPTSTTSFWTPLCTVTMPETEATRAEPDVWLYAWIRFETTMKSGLDPFNMTATFESFDSCDPSDQARVCEAPWNAGSPDSKFGVWRPDPKPADSDDEIDIEPREGWHLPEDKWAEVIKMQLGLYVGERLLICKELSQFDFIIPLQKPFSRGTDKTLIYPAVGEYFHFSAIWSMQHNGFLIYELQPVPLLRQHVTSVNGNLLTRVVPASIRGLFVDKEGTLGLIDDPHHLLSFFEFHPAGYEFLKAMAEVRAVRTSENKSVRYRIVRTSGMSIFENWLRDTQFVVGPVKGIRINEDTVICAKHPNVYFKIPNNLKEGIPIGGGVQFVGKRQAGVDSEIMITECSPCPAFTCKNYSVSGDTRLFQVYLKPNCDHEQLAESDSMGFVDFRELETPCRGKFLAWVRESITVNDCRRAATIMEVCSTAICPPLIAMSANSSRATSARTTPAGSSIGSRSSIQSRASAATSVSSNRFVGPSSRRTPSGTPQSSTSSRV
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASASNYSSAPVSEFLLFCFPNYQSWQHWLSLPFSLLFLLALGANATLLVTIWLEESLHQPMYYLLSLIAILDMVLCLTVIPKVLAIFWFDLRAISFSACFLQMFIVNSFLPMESCTFMVMAYDRYVAICHPLRYPSIITDQFVARAAIFVVARNGLFSLPVPVLSSRLRYCAEKVIQNCICTNLSVSKLSCDDITFNRLYQFVAGWTLLGSDLVLIVLSYSFILKAVLRLRAEGAAAKALSTCGSHLILILFFSTVLLVLVITNLARRRIPPDVPILLNILHHLIPPALNPIVYGVRTKEVKQGIQKLLSRLQ
The following text describes a protein:
Function:
Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1-propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro-hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate.
Subcellular Localization:
Cytoplasm.
Sequence:
MIILDNSIQTKSKAYSISKLITINTLGPEGTSSEYAAKNFITNFTLLQGVNSKLSLHDTFESCIEKTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCDTPMYGLAVRPGFEYTDDMLDKAVIVSHPSPINLIKYFTRKDVTFDLVNSTSAAAKRVKDGLSDIALTNELARQKYGLHFVKTFKSIPMSWSLFGKGEIHDEN
The following text describes a protein:
Function:
Transcription factor involved in phosphate starvation signaling. Binds to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes. Functionally redundant with PHR1 and PHR3 in regulating Pi starvation response and Pi homeostasis. Involved in both systematic and local Pi-signaling pathways. Regulates several Pi transporters. Regulates the expression of PT2. Directly up-regulates SPX1 and SPX2 expression, but PHR2 binding to DNA is repressed redundantly by SPX1 and SPX2 in a PI-dependent manner. The DNA-binding activity is also repressed by SPX4. Involved in root growth under Pi deprivation. Involved in the modulation of Pi response and homeostasis together with RLI1; promotes RLI1 expression in response to nitrate availability, thus triggering the nitrate-induced phosphate response (NIPR).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Interaction with SPX4 trap PHR2 within the cytoplasm and affects the nuclear localization.
Sequence:
MERISTNQLYNSGIPVTVPSPLPAIPATLDENIPRIPDGQNVPRERELRSTPMPPHQNQSTVAPLHGHFQSSTGSVGPLRSSQAIRFSSVSSNEQYTNANPYNSQPPSSGSSSTLNYGSQYGGFEPSLTDFPRDAGPTWCPDPVDGLLGYTDDVPAGNNLTENSSIAAGDELAKQSEWWNDFMNYDWKDIDNTACTETQPQVGPAAQSSVAVHQSAAQQSVSSQSGEPSAVAIPSPSGASNTSNSKTRMRWTPELHERFVDAVNLLGGSEKATPKGVLKLMKADNLTIYHVKSHLQKYRTARYRPELSEGSSEKKAASKEDIPSIDLKGGNFDLTEALRLQLELQKRLHEQLEIQRSLQLRIEEQGKCLQMMLEQQCIPGTDKAVDASTSAEGTKPSSDLPESSAVKDVPENSQNGIAKQTESGDR
The following text describes a protein:
Function:
Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.
Sequence:
TPVHLLPADPEDTAMPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEADNADLVSELRAENQRLTASLRELQEGLQQEVSRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERGELLTTLTSLEGTKALLEVQLQRAQGGTCLKVSGAHSSALGPTSHLWNGHKPGVLRTGMVLGSGGDPGPFMALQEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPMGTPAADSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVRELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSSEA
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MVKLRLKRCGRKQRAVYRIVAIDVRSRREGRDLQKVGFYDPIKSQTYLNVPAILDFLEKGAQPTETVYDILKRAEVFKEFRLNQTKFN
The following text describes a protein:
Function:
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGGRRESAWQCWWGLAVVFLRTVVSRSIVLDPIYWNSSNPKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKDNTPLLNCAKPDQDVKFTIKFQEFSPNLWGLEFQRNKDYYIISTSNGSLEGLDNQEGGVCQTKAMKILMKVGQDASSAGSTQTDPTRRPELEAGTNGRSSTTSPFVKTNSGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing. Binds to the polypyrimidine tract of introns. May promote the binding of U2 snRNP to pre-mRNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAESSKVVHVRNVGHEISENDLLQLFQPFGVITKLVMLRAKNQALLQMQDVSSAVSALQFFTNVQPTIRGRNVYVQFSSHQELTTIEQNIHGREDEPNRILLVTIHHMLYPITVDVLHQVFSPYGFVEKLVTFQKSAGFQALIQYQVQQCAASARTALQGRNIYDGCCQLDIQFSNLEELQVNYNNDRSRDYTNPNLPAEQKGRSSHPCYGDTGVAYPQMANTSAIAAAFGGGLPPGITGTNDRCTVLVSNLNADSIDEDKLFNLFSLYGNIVRIKLLRNKPDHALVQMGDGFQAELAVHFLKGAMLFGKRLEVNFSKHPNITPGTDSHDYVNSNLNRFNRNAAKNYRYCCSPTKMIHLSTLPQDVTEEEVMNHVQEHGAVVNTKVFEMNGKKQALVQFENEEEAAEALVCKHATSLGGSIIRISFSQLQTI
The following text describes a protein:
Function:
Plays an important role in galactose metabolism.
Sequence:
MDMNNKPTFDPKEHQHLRYNPLRDSWVLVSAHRMKRPWKGQVEKPPEDNIPRHDPNNPLCPGSVRANGELNPEYDSTFMFDNDFPALQPDAPDPGSDHHPLFQSKAARGVCKVMCFHPWSDITLPLMQPAEIRKVIDKWADLTVELGATYAWVQIFENKGAMMGCSNPHPHCQVWASNFLPNEASLAERCQRDFLQKHGEPMLVQYARMEAQAQERVVVENEHWLVVVPYWATWPFQTLLLPRRHVLRLPDLTTQERDSLASIMKRLLTKYDNLFEVSFPYSMGWHGAPTGSHLNKNMSHWQLHAHYYPPLLRSANIRKFMVGYEMLANEQRDLTPEQAAEQLRKLSEEHYKVKKAEGKSGVEN
The following text describes a protein:
Function:
Needed for flagellar regrowth and assembly.
Sequence:
MVPHDKDKDNPSELIRGKDVAAFGLWSLPSFDEPRDEPAVAAPQVPAVAEPAPAPPAVEEVELETVKPPTLEEIEAIRQDAYNEGFATGERDGFHAGQLKARQEAEEALKERLQSLERLMTQLLEPIAEQDALIEQGMVNLVNHVARQVIQRELHMDSSHVRQVLREALKLLPMGAANIRIHVNPQDFERVKALRERHEESWRILEDDSLLPGGCRIETEHSRIDATIETRLAQAVKQLFEQQREQATHPLASDIRIDLDAPGDVDAP
The following text describes a protein:
Function:
Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle. Note=Also found in ER-derived COPII-coated vesicles.
Sequence:
MSYNPYAYATSEQNGVNDRFSHTPQQQRPMQIPRNTPVNGQGNANMNANVNGSGGGFPFQDPRGSMAFQLGQSAFSNFIGQDNFNQFQETVNKATANAAGSQQISTYFQVSTRYVINKLKLILVPFLNGTKNWQRIMDSGNFLPPRDDVNSPDMYMPIMGLVTYILIWNTQQGLKGSFNPEDLYYKLSSTLAFVCLDLLILKLGLYLLIDSKIPSFSLVELLCYVGYKFVPLILAQLLTNVTMPFNLNILIKFYLFIAFGVFLLRSVKFNLLSRSGAEDDDIHVSISKSTVKKCNYFLFVYGFIWQNVLMWLMG
The following text describes a protein:
Function:
Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi. During Gram-positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation. Functions in a separate pathway to the psh-mediated activation of the Toll pathway.
Subcellular Localization:
Secreted. Note=Localizes at the membrane of lipid vesicles. Secreted from the fat body into the hemolymph at the surface of these lipid vesicles.
Sequence:
MQLISFLSNPLFFCALLLKFRTIFAACDSSQFECDNGSCISQYDVCNGEKNCPDGSDETALTCVSQRQHCTKPYFQCTYGACVIGTAGCNGVNECADGSDETRLRCGNEDDIRQHDRRLQGNCKENEFKCPSGICLDKSNFLCDGKDDCADGTGFDESVELCGHMECPAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGCPLPLGDERPILTGDGSRVLTGPITRGTVRFSCKQGYVLEGEESSYCAKNKWSTSTIPKCVKYCSTAGEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFKTLSPLPEMRCMKGGYWNRGRQRCEQDCGQLATPIKQFSSGGYTINNTVVPWHVGLYVWHNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPEEKRRDVRLIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPICVTFASFAEKESVTDDVQGKFAGWNIENKHELQFVPAVSKSNSVCRRNLRDIQADKFCIFTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGVISNAPNADQCAHSLTVMTNIQHFEDMILNAMNRSVETRS
The following text describes a protein:
Function:
Part of an ATP-driven transport system TM_0123/TM_0124/TM_0125 for a metal. Probably responsible for energy coupling to the transport system.
Sequence:
MKIVEVKNLTYRINDFEILKNVTFSVEEGEFVGIIGPNGAGKTTLVRILVGDIKNYEGKVEVRGKIGYLPQLHQVQREFPITVKEFAAMGMYGRYRKIDWEKVRSTLKDVGILHKENDPIKNLSGGEFQRLSLARALLSDPDILVLDEPEAGVDEMGKASFYELLNRLRKEKNITVIMVSHDIGMVFKECSTIMCLNRTLHCHGPTETINPEDLKKIFTDFDIWIRGTRHYEIYHGRERD
The following text describes a protein:
Function:
Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
Subcellular Localization:
Cytoplasm. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes.
Domain:
The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.
Sequence:
MAAPRSAGPRGHREGGAGMRPGVRRCPISVLPVLSVSPSCLSVSVCLRQEELEHLNQASEEINQVELQLDEARTTYRRILSESARKLNTQGSHLGSCIEKARPYYEAGGWAKEAQQETQKAALRYERAVSMHNAAARWSFVAEQGVMADKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLCQQAEARVQALQKALRRPIAKSRPYFELKAQFNHVLEEHKAQVTGLEQQVAQAKTRYSVALRNLEQISEQIHARRRGPPPPPGSRRTSPVGAEAAGAAGAGPAADTLSQLSLRTVASDLQKCDSVEHLRGLAERASLDGRQLSPGGRAGREDAGERGAARHQRSLSL
The following text describes a protein:
Function:
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis (By similarity). Colocalizes with TJP1.
Sequence:
MSEPHRVQFTSVPGSLNPAFLKKSRKEEVGGTEQHQDCEPAAAAVRITLTLFEPDHKRCPEFFYPELVKNIRGKVKGLHPGDKKKDVLDPFNDEEKERHKVEALARKFEEKYGGKKRRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQFRQASESEDDFIKEKKKKSPKKRKLKEGGEKIKKKKKDDTYDKEKKSKKSKFSKAGFTALNASKEKKKKKYSGSLSVREMLKKFQKEKEAQKKREEEHKPVAVSSIEAQGLRELEGTSDPLLSLFGSTSDNDLLQAATAMDSLTDLDLEQLLSESPEGSPFRDMDDGSDSLGVGLDQEFRQPSSFPEGLPIPLEKRVKELAQAARAAEGESKQKFFTQDINGILLDIEVQTRELTSQIRSGVFAYLASFLPCSKDALVKRARKLHLYEQGGRLKEPLQKLKDAIGRAMPEQVAKYQDECQAHTQAKVAKMLEEEKDKEQRERICSDEEEDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESRDLERNSKAQAWEDCVKAFLDAEVKPLWPKGWMQARTLFKESRRGHGHLTSLLAKKKVIAPSKIKMKESSVKLDKKVSVPSGQHGGPTTLLSEHQGGGLNTGANSREHPSQATCGLTDSVSVTLEDSLDEDLVRNPASSVDAVSKELATLNSRAANSSEFTLPTPSKAPTEKVGGVLCTEEKRNFAKPSSSAPPPTNALQSPLNFLAEQALALGQSSQEKKPEGSGFKELSCQGPLSKGVPELHPSKAKHHNLPRTSHGPQAAAPVPGPQVKVFHAGTQQQKSFTPPSPFVNKLQGPKATSPQCHRSLLQLVKTAAKGQAFHATMPASSGSSPASSSSAHKTTASNSTTISHPAKLHPTSSVGPSYKNNPFAGSVSKHGASSSSPSPGGGAQVQSSVSGASLPGVQSPSAGQSASRAAPSSAVKKTPVTQKLTLVAPPGGPNGDSGGGTQGVAKLLTSSLKPAAVSSVTSSTSLPKGTGGAVLLSNTSSLSLLSSSYKSNNPKLPGAMNSNSLGIITQFPLHVLSFNADSSAKAGVSKDAIVTGPAPGTFHHGLSHSLLAGLHSSPPHTAPLPHAAVSTHVPQSLPDASQLHGKGPVVPRKL
The following text describes a protein:
Function:
Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=145 nM), Kv1.2/KCNA2 (IC(50)=2.5 nM), and Kv1.3/KCNA3 (IC(50)=15). Also inhibits calcium-activated potassium channels (KCa/KCNN).
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).
Sequence:
VGCEECPMHCKGKHAVPTCDDGVCNCNV
The following text describes a protein:
Function:
Aminotransferase that has 6'-oxoglucosaminyl:L-glutamate aminotransferase activity by catalyzing pyridoxal-5'-phosphate-mediated transamination leading to the conversion of paromamine to neamine in the biosynthetic pathway of kanamycin B.
Sequence:
MSTHPVLDWSRSAEHLRRSHGVTTDPRPDEDGHYPCVLTRGSGTRVYDLDGNAYLDLTGSFGSVLIGHAEPAVVRAVTDVLSEGNLFYTGASPRRLALAERLLDWFPWSEQAIFYRTGSCAVSAAARLAQHATGRNRVLSSGYHGWHDWHLEAVPEAKPKTFESYATEFHNDLALYRSWLDRHGEEIAAVVVTPEPHRFDHAYYQELREVAKEHGCLFVVDEVKTGFRAGAGGFSALAGIEPDAVTVSKGMANGHSISAVVGQRQLTQELSEAHVWSTYQNEQVGFAAALASLDFLERHDVAAVTRRTGEAVRQGVLQLFAEHGLPVGAPGWGPMFELDFDAADEGLAERLEAALLRHGIFCDTGDDFNMMFHTAEHTDELLERFAAALGDL
The following text describes a protein:
Function:
Antimicrobial peptide required to resist Gram-negative bacterial infections, regulated by Dredd.
Subcellular Localization:
Secreted.
Sequence:
MQFTIAVALLCCAIASTLAYPMPDDMTMKPTPPPQYPLNLQGGGGGQSGDGFGFAVQGHQKVWTSDNGRHEIGLNGGYGQHLGGPYGNSEPSWKVGSTYTYRFPNF
The following text describes a protein:
Function:
Essential for progression through the whole cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MSEVIKSVPPGSQNTSQWIISKDQLVFTPSALDGIPLDQEEIQRSKGCNFIINVGLRLKLPQTALATANIYFHRFYLRFSLKNYHYYEVAATCIFLATKVEDSVRKLRDIVINCAKVAQKNSNVLVDEQTKEYWRWRDVILYTEEVLLEALCFDFTVEHPYPYVLSFIKKFVADDKNVTKVAWTYINDSTRSIACLLYSPKTIAAAAFQFALEKNEINLSTTTDGLPVWMEESQVSYEDVKGVLTLIDSLYKKINPSKQALPIDQKNGSHASSVAPGTPSSLASVSTQATPQHQNSSGRTDSFHSLNTETPSKSTVDDQILSTAAQPKKSSDTDKEMETEAS
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol, ethyl acetate, propyl acetate, and pentyl acetate. Also responds to pyrazines.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLRRWFPTLYTQSKDSPVRSRDATLYLLRCVFLMGVRKPPAKFFVAYVLWSFALNFCSTFYQPIGFLTGYISHLSEFSPGEFLTSLQVAFNAWSCSTKVLIVWALVKRFDEANNLLDEMDRRITDPGERLQIHRAVSLSNRIFFFFMAVYMVYATNTFLSAIFIGRPPYQNYYPFLDWRSSTLHLALQAGLEYFAMAGACFQDVCVDCYPVNFVLVLRAHMSIFAERLRRLGTYPYESQEQKYERLVQCIQDHKVILRFVDCLRPVISGTIFVQFLVVGLVLGFTLINIVLFANLGSAIAALSFMAAVLLETTPFCILCNYLTEDCYKLADALFQSNWIDEEKRYQKTLMYFLQKLQQPITFMAMNVFPISVGTNISVTKFSFSVFTLVKQMNISEKLAKSEMEE
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAMLGGEAMPRILMQVIRFCINSDDKPLKKLCMLYWERKLLPEMILVCNALMNDLNHPNEFVRGSMLRFLCKVKDEEILGPLIPSIKACLKHRHQYVRKNAVLAVFHAHRLHGDTLIPDGPELVGEFISTETDIGARRNAFLMLYNESEDLAIQFLAHNLDDVSKFGDGFALLVLDLTRKACRRDPNQKSRFVRVLFQMLSSTSSAVSYEAAWTLISLSNSPTAVRAAAVTYTNLLNSQNDNNVMMIVLERLEQLQVKHSKILQELLMDILRALSSPNPDICRKVLDVAMSLISHKNVVEVVTVLKREVGKTTQESSDSSEDKGKVYRNMLITAIHGCAVRFPEVAESVVHTLMDFLSSDGGMQVIIFVRAIVERYPNLRPAVLTKLINTLDEVTNGNVMCVCLWILGEYCETSETVKDAFDKVTEQLGEAPFVVAADDKKAQEKAAAEAAKGPKMVTKNVILADGTYATQTVYSEPKMNLSLDKTPHLRKMIIGGDIFLGTIIASCLTKMCLRAPDVGIDAVTSKAMNVKSLLIMCGIVKMAEVTVSAQKTSLADCSERVSLSQADDLIHFRQLRSLAAQGGDIDLDDGTDLARATGYADGGSLLSNELSHVYQLSGFADPVYAEAFVTVHEYDILLEILLINRTPNTLANLTVELSTMGDMKIVERPQSHTIGPLDQMTIRASIKVSSTETGHIFGTIVYEDASTQEKGYINLNDIHMDIMDYIRPATCTDEVFRSMWAEFEWENKVAISTSISGLVEFLDHIVTSTNMSCLTPHDRNEKGSFLAANLYAKSVFGEDALVNVSVEKKDDNDGKLAGYIRIRSKTQGIALSLGDRITSVQRGHTQ
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSYYQQQCKQPCQPPPVCPPPKCPEPCPPPKCPEPCPPPVCCEPCPPPKCPEPCPPPVCCEPCPPPVCCEPCPPQPWQPKCPPVQFPPCQQKCPPKNK
The following text describes a protein:
Function:
Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. Preferentially cleaves single stranded RNA at poly-U sites with CU, UC and AU sites cleaved less efficiently. May target mRNAs encoding proteins involved in lipid metabolism to regulate their expression. Regulates levels of TBPH protein, but not mRNA, by an as yet unknown mechanism. Important for neuronal development or function.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MDAVQQQTNSTSNIDSAKCQKLKRFVIVGLLITIGILSWHFYEYFHSKPLPKTPDDVLTLSKNLYAEETEVSPYLYKVNLQGKTTSGAHDDRAPRNLFELHQDLLARDANSTTALLMRLFDNYELDVAVQEHPTPEHVQEQYDFLRAVMGTRVMKLTMRFLVHKDIVSVEYDDQLRLLQELWFTPYSRGRGIVGSSSFEHVFMAEIRDQKVLGLHNWLYFADQEQRGNVDYKGWLNHKEMGKHNQMVLSVRYTFHNINKPVNGFFVGISPELDMALYTACFLATAKEEPCHIQLGHASATIVSHEWKWNGMRLIGTVYPDSS
The following text describes a protein:
Function:
Is essential and sufficient to confer resistance to the bacteriocin sublancin 168.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=A small amount is also associated with the cell wall, but this is probably contamination.
Sequence:
MEYVVMIIILLALFFIFTVFLNTRYSFDEKCLVLKFGLSKTEIPINQIVSIKESDKYGVADNIDYKIGMPYAQPDRIVIETTNKRFLVFLNGAQQFIQKYKRVSV
The following text describes a protein:
Function:
Required for release of calcium ions from the vacuole in response to hyperosmotic shock.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MVSANGDLHLPISNEQCMPENNGSLGFEAPTPRQILRVTLNLKYLIDKVVPIVYDPNDIVCDHSEILSPKVVKLAYEACGGNPKDKANKRKYQSVIIFSLLKVCEWYSILATMEVHNAKLYETRNLASQQLCKLLIEREETRDLQFLFMQLLLRRYVINENDEDQEPLNALELATDMHCTTVIGSSGFQRCLKWIWRGWIVQNGLDPTTFIKDDSLAEVSLISHFNPVRLKAPVYQNYLQMIFSFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGYAHLSFWNLFNDTTYLIITFAMGFRAMSVTPLNAKYSSEDWDKISYRVLSCAAPFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLIMIGFTQGFLGLDSADGKRDITGPILGNLTITVLGLGSFDVFEEFAPPYAAILYYGYYFIVSVILLNILIALYSTAYQKVIDNADDEYMALMSQKTLRYIRAPDEDVYVSPLNLIEVFMTPIFRILPPKRAKDLSYTVMTIVYSPFLLLISVKETREARRIKYNRMKRLNDDANEYDTPWDLTDGYLDDDDGLFSDNRNSGMRATQLKNSRSLKLQRTAEQEDVHFKVPKKWYKNVKKCSPSFEQYDNDDTEDDAGEDKDEVKELTKKVENLTAVITDLLEKLDIKDKKE
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Plays a role in the speed with which bacteria traverse human epithelial cells; disruption of the locus increases the speed of trafficking about 2-4-fold. Binds to its own promoter, binding affinity of the FitAB complex is 20-30-fold higher than FitA alone. No nuclease activity was observed for the FitAB complex, perhaps because FitA (the antitoxin) prevents metal binding and thus catalysis by FitB.
Sequence:
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL
The following text describes a protein:
Function:
Has antibacterial activity against the Gram-negative bacterium E.coli. No antibacterial activity detected against the Gram-negative bacterium V.vulnificus.
Subcellular Localization:
Secreted.
Sequence:
MNGLFLFCVATTAALAYGSDAPCTNSGGVCQDDHLACHNGHYQSGLCTGGAHRRCCLTSASHTGSFSTGIVSQQCLQCICNVESGCKAIGCHFDVNSDSCGYFQIKEGYWHDCGSPGSSWRSCANDLACASKCVQAYMSRYIGFSGCSHSCESYARIHNGGPAGCKHTNTLGYWSHVHAQGCSHNSK