lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MNFGAPWDSLKKSIPQVPDALLHILKSRFSFTNMTPVQECAIPLLCQHKDIAAQAETGSGKTFAYLVPIIVSLIEKIPRLLDVEDESLNESDPRSGYIHALIVAPTQVLAQQIYDVLIQIISRHYVLLLIGGTDAPIDQASGSLLDRPLVVATPGRLRYYLADGLVSLKDLEILIIDEADQVIVSKDFPYIRAKLPSQRRTGLFSATFDSVTEADLALLMRNPHVVKLYNAAKEQDMYIVPQNLVMWYKVVPYEQKLYMLLRHINALRSQHKADSPKKLIVFFMTCSMSQYMSFAFTHIFELLPDQQVGIYCFNGKQSQETKIKNYNSFLADTRFAVLFTTDISARGLDISDISHVLQFDPPKLIATYTHRAGRTARCYRSGDAGIFLGLEEIGIVSLLRTRGVPLRELTSEQDAQLFDVCTTDMPGCEFTNLITSPPASPDRSALTAEEFSTLQASIKELTQKTKKLTRALATNQQRASLAAESADSTTTAVQKMQSVIHTTIELPLNEARKRLSILLEQEKNYLEQKNYMYDHNLTKFLRQVQSEKREVFESCQRALETWLSGYNENEAKLIFNVEKLPLGEFAVSLGLLKLPNHNILRRKHINFKSVDIDVSKIVYSNPKREESRQVQLDISTRKKEAREQMRQERELSRHKEGSNEITEAIRTSLTQHALSHGNRVPAQFSGEARLLSLLKGGKITEDEFDEMIDDLALSGGKMSKNPAKIRKWRR
The following text describes a protein:
Function:
Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYAPPGNAVPANRRRRGGTALPKQPERSLASALPGALSITALCTALAEPAWLRVHGGTCPRQELGVADVLGYIDDKLIDEFCINSQSILLLRVIAAFCFLGILCSLTAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFCYWASELILSLQQQHKKYHGSLIYVTFAISFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEESSETYPADYDIANQFQPPPAYTP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
Subcellular Localization:
Nucleus.
Sequence:
MKEVVVDILPKRISGLEFSALSASDIVAQSEVEIFTRDLFDLEDGRAPKKGGALDSRMGVSSSQAECSTCHGTLASCHGHFGHIKLALPVFHVGYFKATIQILQSICKNCAKLLLNEEDKRQFLSELRRPGIDNLRRMATLKKVLDQCKKQRRCLHCGMLNGVVKKAAAGSGSAALKIIHDTFRWVGKKSAPEKDKWIGDWNQVLQHSPELERYMKRTMENLNPLKTLNLFKQISPQDCELLGIDSTVKAGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLEKGISINNMMEQWDYLQMAVAMYINSDSVNPALMPGGNGGGKTKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTFPEKVTRYNKHKLQQLIVNGANVHPGANYLLKKNEEARRNLRYGDRIKLAKNLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSFFDRATFVQMLSMMSDGNLQFDIPPPAIMRPHYLWTGKQLFSLLIKPNKKSPVIINLDAKNKVYIAPKNKAYPNEMSANDGYVVIRGSNILSGVMDKSVLGDGKKHSVFYTILRDFGPQEATQAMNRMAKLCARYLGNRGFSIGISDVTPGVELKATKEEMVEIAYAKCDELIDLYKRGKLETQPGCNEEQTLEAKIGGLLSKVREEVGDVCIRELDNLNAPLIMATCGSKGSNLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSSNGIVQFTYGGDGLDPLNMEGNAKPVNFNRSWDHANNITYNHDDKGMLPYQILEETNAILHPLEQQLSRYDNVGNPLAPGLENEELYIDQHDAEREFYQSLRTYMSEKARKLADIRKSRGLKELYHAPALELQLMDLDASCPEVDVKSVNQLCKISSKLVRTFLDIAISKYRKAKVEPGTAVGAIGAHSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINATLVNDDDERAARVVKGRVEKTLLSDVIFYIQDVYRDNMSFLQVKVDLATIEKLQLELTVEDIAIAITSAPKLKISTGDVSIVGRNKININVCNDLDKAKSISTLASEPHENDVFFKMQHLRRALPGIVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMTTDGVVGYKTKTNHFLEVYDVLGIEAARTSIIDEIDYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMTIGTGSFKVVKGTNISPDDLKPKPTLFENLCSLNTLKVN
The following text describes a protein:
Function:
Required for the growth of imaginal tissues and for patterning of the adult wing.
Subcellular Localization:
Secreted.
Sequence:
MSGLRNTSEAVAVLASLGLGMVLLMFVATTPPAVEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEILEFLGIAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNFITDLDKRAIDESDIIMTFLNKRHHNVDELRHEHGRRLWFDVSNVPNDNYLVMAELRIYQNANEGKWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGCH
The following text describes a protein:
Function:
Plays an important role in slowing down the growth of mycobacteria within the infected host. Activates the peroxidase activity of Rv2159c in a phosphorylation independent manner during oxidative stress conditions and thereby maintains the cellular homeostasis.
Miscellaneous:
MISCELLANEOUS: Several structural motifs known to be critical for the activity of eukaryotic-like Ser/Thr protein kinases (ePKs) are severely degraded in PknI. No kinase activity was detected by Lisa et al. for the catalytic domain of PknI, against different substrates and in various experimental conditions, suggesting that PknI may rely on unconventional mechanism(s) for kinase activity and/or it could play alternative role(s) in mycobacterial signaling.
Subcellular Localization:
Cytoplasm. Cell membrane; Single-pass membrane protein. Note=More abundant in the cytosol than in the cell membrane.
Sequence:
MALASGVTFAGYTVVRMLGCSAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLARLDGVLSRALATAPADRFGSCREFADAMNEQAGVAIADQSSGGVDASEVTAAAGEEAYVVDYPAYGWPEAVDCKEPSARAPAPAAPTPQRRGSMLQSAAGVLARRLDNFSTATKAPASPTRRRPRRILVGAVAVLLLAGLFAVGIVIGRKTNTTATEVARPPTSGSAVPSAPTTTVAVTAPVPLDGTYRIEIQRSKQTYDYTPTPQPPDVNTWWAFRTSCTPTECLAAATMLDDNDHTQAKTPPVRPFLMQFGEGQWKSRPETVQFPCVGPNGSPSTQATTQLLALRPQPQGDLVGEMVVTVHSNECGQQGAVIRIPAVASRSGDLPPAVTVPDPATIPDTPDTTSTATLTPPTTTAPGPGR
The following text describes a protein:
Function:
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Subcellular Localization:
Cytoplasm.
Sequence:
MEHLLKTDPEVFDAVVKEYERQFYNLEMIASENFTSLAVMEATGSVLTNKYAEGLPGKRYYGGCEYVDVVENLAIERAKKLFGAEHANVQPHSGSQANMAVYFAVLNPGDTIMGMDLAHGGHLTHGAKVNFSGKLYNVIHYGVNPETELIDYDQLYKLAKEHKPKLIVGGASAYPRVFDWAKMREIADEVGALFMVDMAHYAGLIAGGVYPNPVPYAQFVTSTTHKTLRGPRSGFILTTKEYAKAVDKSVFPGIQGGPLMHVIAAKAVAFKEAMSEEFKEYAKQVVENARVLAEELKKYGFKIVTGGTDSHIVLVDLRNKNIIGKDAEKALEKAGITVNKNAVPFDPLPPTKTSGIRIGTAALTTRGMKEDEMRKIAGWINEVLSNMDDEKTIQRVRQEVRELCETFPLYPELKRRIDELRSGKATDL
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MMEQLETIEALKRTSKGCGLFRKPDSNNNNANTVQFKKDDSDTMQTNDKIRSHSKSPEVIWKTNAELSTGDEKENRQNTLMQESSSDNKPKYNNNDDINDDSQNFLSTPLNKISLSESIISYCDEEIDLKVKNFMLAKQSDLERKETKQRENVLVEKNVLQEKVQKKILKIQDEDNDFERAYNEELMATQNQLKEVHNRHAQLLNKRDSDAQKDALRKEQEKLEQKVVKGRKEVHKCIEEMNNLLKVHNFTDNLPPPVGSCVDVLKQISDKIADISSPATLTDLDARSVAFLSAEAKKIIAIAETLIVEASRKRLEEKIKESEKAVHIRSSTAAEVATTFTKTTSAKTASSAAPQVSSRLSPQPANQCRAIYMEFLKLLNSVEMDCKEFEEDTVLKKYRFSLMKAVSENVNTINNNEPGHLHDKVEKFIRLLEGGTIGVSGDQNVSTRDHPVASLYCLNRLAKKLVNQGGELVSSRPEAAFIYSPVVVGLWCKYPIFGKLFLVHLALKCPFLVPYIIEREGKSDLEYFQMLGYDISDNGELEKESLFLKRFSGYVTFYAAVTVSQPPSNHLLGRKIKLQSPHGLQNAWTWLARVLGQPPIQGITPTALHSFLEVVGFEMGRCYGKQFFKMLQFLKFIYLPEIKKVTTDSDKIAPLERLRLFVDGAFSKGKIVRHPGLKKMIK
The following text describes a protein:
Function:
Has role in the regulation of chemotaxis.
Subcellular Localization:
Cytoplasm. Membrane. Note=Cytosolic in unstimulated cells, localizes to the plasma membrane in response to chemoattractant stimulation with kinetics consistent with those of kinase activation, where it binds to phospholipids via its PH domain.
Sequence:
MISLDLSPTLWKSPDKEGELKKQGHVVKNWKKRKFIIQNDMLFYFKDKEERPVGAVPLRMSRCYENKSLGKPNCFELVSPRINKTFFIQANTPDEMASWMKAVEKGSEYSTVSQPFNLKHEVHVDFNSATGFSGLPKEWEVILKSSNVSKQEVLDKPSEWLSVLEFQAGRTMEKSNSQNLSALPDESNLTLSDLVTKEDPTKIYKNMTKIGEGAAGEVFVATSSKNNKRVAIKKIEINNDNAKLLVTEIAIMKTSHHDNIVNYIDSYIVNDRELWVAMEFMGGGCLTDILEAFDNIKMSEIQIAYVVKETLKALQYIHSLHRIHRDIKSDNILLGSEGSVKIADFGYAAQLTQKQQKRNTVVGTPYWMAPELIRGHDYGVKVDIWSLGIMMMEMAEGEPPYMDFPPLRALFLITTKGIPPLKETTKWSKTFQDFFSKCLDINVANRPDATDLLKHPFMDLACDSSEFKPLIQAARNV
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MDKLIVSLQYSGFLGSIVLNALLLHLLFHKASSSFGRYKILMISFSIFAIFYSIVDVLTLPVIFAKGRSICVCSNGPLKLFRSIGVPLTAVYCGSFGLCISLLALHFFYRYIAVCKPEKMYYFDEKHICYTFVLSIFIFVAWTITTYFPMLPDEMREEYYSDVLMDNFLTDSHETSFLVMMYKTPPDRPEPVEWIYSQLLACGFMCFQMSTCSFVMLFCGYKAVVQMKHSEVHMSSKTRNLSRQLMMTLGAQTLLPFTTVFLPVGLIIVLPVFGIDVGVAANKTAAFLGIYPALDPMIAIFLIKDFRYFVFCRSESSYVSSALSLTSHPSKVFKIVKRNNAA
The following text describes a protein:
Function:
Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIVCNVVVITYSALHPTAPVEGAEDIVQVSHHLTSFYGPATGLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTVPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIENILKIPLGKFTPWLAIIEGILTAWIPAWLLFIQHWV
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
DPQDCTCAAGDSCSCAGSCKCKNCRCQSCRKSCCSCCPASCSNCAKGCVCKEPASGKCSCCH
The following text describes a protein:
Function:
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
Sequence:
MDAFKQQLEQLSAKNQYRSIPDLVHQGRYITRENRKMLNMSSNDYLGLASNENLRQSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANIGILPALTTTKSLILADKLVHASMIDGIRLSQCEFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAVGVYGQNGLGIAERANVIADIDLLVGTFGKALASMGAYVVCDQILKECLINQMRPLIFSTALPPFNVAWTHFIFERLPQLSKERTHLEQLSAFLRQEVEHRTQIMPSQTCIVPYILGENEATLAKAKDLQEQGYYCLPIRPPTVPKNTSRIRLSLTADMTADEVRQFAVHL
The following text describes a protein:
Function:
Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2. Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization.
Subcellular Localization:
Apical cell membrane; Single-pass type II membrane protein.
Sequence:
MVSVAGGRTVPCCSGSKVAALTAGTLLLLTGIGAASWAIVTVLLRSDQKPLYPVQVSPADTRLTVFDETEGTWRLLCSSRSNARVAGLSCEEMGFLRALAHSELDVRTAGANGTSGFFCVDEGRLPYARRLLEVISVCDCPRGRFLATICQDCGRRKLPVDRIVGGQDTSLGKWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQMGVQAVIYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGPDFYGNQIKPKMFCAGYHEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTLT
The following text describes a protein:
Function:
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MKNLSIQPHHLPNNNICIKVLAEGAANVIYQITIDPKSQGVIEVDKDHQDLDYLSGKLLRLRKDVPTTAPTSESYQQWLTYIVPLFKPEQIVIQELIYIGHLNVIPGLNTDLRRFDNPGTCTTNHLVPPPKGKFYRSRAQSGTFLAKDDYGLLITDMTPRKSAQETVVEFKPKWLSPSHELPSKAIRCRTCALHARRVAFGEERKNTDLQSYLCPLKLVDDDPKLKFESYLASASHVLHKPHETPSVQSLARWIHENPLLKRLRDLQTEYDLKGSLKTEKASHELCVAMTLRDCSLYIRMDKNHQVIEARLGDLDYKSPNKYSSWRRKEQELIDEGWYCGEESKELKQPIDECLLSRRI
The following text describes a protein:
Function:
Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The MBT repeats mediate binding to histones tails; however, in contrast to other MBT repeats, does not bind specific histone lysine modifications. The MBT repeats lack the conserved Asp and aromatic cage at conserved positions (By similarity).
Sequence:
MNGEQQLDADLGSGVEVEEFSWEDYLEETGATTAPYASFKHVDICLQSGFAPGMKLEVALRKDPETYWVATVITACEQLLLLRYEGYGEDRKADFWCDIRRAGLYPIGWCQQNKKTLEAPEGIRDKVSDWSAFLQRTLTGACGPPVALLEGLRNGRNPLDLIAPGSRLECQDFRDSVSTWIVTVVENIGGRLKLQYEGLERHDGFEHWLYYLDPFLHHIGWAAQQGYELQPPLAIRHLKNEADWQEILARVKEEEPLPSYLFKDKQVIRTHEFSINMKLEAVDPWSPFGISPATIAKVFDDKYFLVEIDDLRPEDHARRSFVCHANSPGIFPVQWSLKNGLHINPPPGFRSQDFDWADYLKQCGAEAAPQKCFPQSVSEHQFKENMKLEAVNPLFPEEVSIATVTAVRGSYLWLQLEGSKKPVPEFIVSVESMNIFPLGWCETNGHPLSTPRRARGHKLRKIAVVQPEKQILSSRTVHEGLKNQLNSPHSVMINGKYCCPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYKGKSYRATVEIVRTADRVTEFCRQTCIKLECCPNLFGPRMVLDTCSENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLSCALKKTSKRRKRRKNIFVHKKKRSSASVDNTPVGSPQGSGGEDEDDADDGDDDSLTEGSTSEQQDELHEESEVSEKKSCSPSPTQSEMSTPLPPDTQTDKREAQTSSLSDGENKPPSPKEIRIEVDERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIKFAFYEQFAN
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
MSEQSCQMSELRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRENRVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELSAPSLHALLLVIAIGHFTREDEETAKGIQQVFGAEARKHIIIVFTRKDDLGDDLLQDFIEKNKPLKQLVQDYEGRYCIFNNKTNSKDEQITQVLELLRKVESLVNTNGGPYHVNFKTEGSRFQDCVNKAASQEGDKPHGPRERQLQSTGPEQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHICTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQKCKNRYSAFNYRATGEEEQRQADELLEKIESMVHQNGNKHCVFREKETLNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSFNQMLDVEKDPSRLEEEVKRCLSCCEKGDTFFVLVFQLGRFTEEDKTAVAELEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDNKALRRIFKKCGRRVCAFNNKETGQAQETQVKALLTKVNDLRKESGWSGYPHTQENVSKLIKNVQEMSQAEKLLKNLIGILQ
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Subcellular Localization:
Mitochondrion.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MYNSAKQLQRVLTAREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTAAAPHKRVVNSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPYNIDPGRLYVTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHRPDLGSVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKSSNYDTDLFTPIFDGIQQAAKTPVYSGSFPDGGNAAVLDTSYRILADHARMVTACLADGMLPDQNQKLRRVLRKALNISEHVFAHDKLLTQLVPIVVETLGEAYPEMAAKQQAVIDLICHEQEVYKNLRESSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYKLTDTYGLTEESFLKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAMLTKRLTPTDNSHKYTYSFDKESDSYQIPPLKTRVLGMLLNDAEVSRTQGSRIQQPFTDLISIVTAGSNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAFQLAIGDEVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRIQKTDVQLIEDLINRVICSAAPVEVQLLSAAEVLEQNDITMVPGEVYPEQGLRLVNVESPELQLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRHRVDLLEKQFQTDKLTNATEAELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRIKDSSRTTLKEFVDVEMRTLLQEKPLDTHPFILHYITSSALVEEIPLQRATKLCPDRPILVISVCDSVVKARCCVPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNLFEEQLEQAMSKAHAYAKLYL
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MTSTVESLSSVKKKISFEIPADRVTSEIDKVFEKIRKRAAIKGFRKGKAPQSLIEKHYADVMEGDVLKNLFEETYFKALAEHKIFPVSHPVIDSDEIKRGTPFTYSATVEVLPEIDVKDYNGLEVAKETFTPDESIVEKRLQEMRENMSHLRSLEEGSVAEDGHFAVIDFTGYVDGVPFEGGSAESYQLELGSGRFIPGFEEQIVGMKTGESKSMSLNFPEDYWNKDLAGKEARFDVILSEIKVKELPELNDEFAAQMGEFDTITQLRDKIAELYEKQENDRIKADLQDRVVQALIEKNEIEVPSTLVDRQLQTMLANAQNRLAQQRLTFEMMGMNEESFKAQYRTVAENQVKGSLLLEAVAKKEGISVEEADIEKKLLEIAGGNEEELGRVKSFYEQNRAARENLVAHLAEEKVMSFLLGSAVISEKTKE
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
Sequence:
MESTFSSPAEAALQREAGVPGLFTPPEDLDRVYELERVTKFVCDLGCQRVALQFPDQLLGDAGAVAVRLEEVTGSKMFILGDTAYGSCCVDVLGAEQAGAEALVHFGPACLSPPASLLPITFVLGQRSVALELCAKAFEARNPDPTAPVVLLSEPACAHALEALATLLRPKYQDLLISSPALPLPVGSPSSQPEPLERFGRRFPLSPGRCLEEYGAFYVGGSQASSDPVLDPDLSRLLLGWTPGRPFISCCPDTGQTQDQGVQAGRLRARRLYLIERARDAHVVGLLAGTLGVAQHREALAHLRKLTEAAGKRSYVLALGRPTPAKLANFPEMDIFVLLACPLGALAPQPSGGFFRPILTPCELEAACNPAWPPPGLAPHLTHYAELLPGSPFYVPLPPPESELWDTPDVSLISGDLRPPPSWKSSSDTGCSALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVKEAVQGRRGIAIAYEDEGSG
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFIRAPNFGRKLLLTCIVAGVMIAILVSCLQFLVAWHKHEVKYDTLITDVQKYLDTYFADLKSTTDRLQPLTLDTCQQANPELTARAAFSMNVRTFVLVKDKKTFCSSATGEMDIPLNELIPALDINKNVDMAILPGTPMVPNKPAIVIWYRNPLLKNSGVFAALNLNLTPSLFYSSRQEDYDGVALIIGNTALSTFSSRLMNVNELTDMPVRETKIAGIPLTVRLYADDWTWNDVWYAFLLGGMSGTVVGLLCYYLMSVRMRPGREIMTAIKREQFYVAYQPVVDTQALRVTGLEVLLRWRHPVAGEIPPDAFINFAESQKMIVPLTQHLFELIARDAAELEKVLPVGVKFGINIAPDHLHSESFKADIQKLLTSLPAHHFQIVLEITERDMLKEQEATQLFAWLHSVGVEIAIDDFGTGHSALIYLERFTLDYLKIDRGFINAIGTETITSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLSERGVNFMQGYWISRPLPLDDFVRWLKKPYTPQW
The following text describes a protein:
Function:
May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MRSRIMAKGLYIALLMKFSIKYQVMALAAQNHKMETLIQKENQASRFSGKEMNTGQKASTSVLRRGTKRKDPQFASYKRRGDRKLFLKKMAENPNQKEMFTTETNYSSYEMIRAKHNSCGNIRFSSDPEEKDPNLQTKKVLTPKRNNPVKTMEIPGVEGLYEIPKRSISKKMEMDVENDVSDSDEDYNEEEDDDDDDDDSTLISSLRRSNSSKCKRNQTKDCRASNEKPTSKKIKDDSNSLISSLRRSNPSKCKRNQAKDCRASTEKPTSKKIKDDSNKKEKSNEKQEEKEEEIKDTKQNDVNNTPHHERVMRNRRAASARNKIFENGFFFGVWEDEEDDIVVKEEEDDDFGDDDDDDYVVDDEGNEDENVLLTLTHHHELKDVKTKETLKKVKLENDIDFIEDKKQMSFVKSTPSKSSSSSDTITKRRMRDTGDCSSASSDHITTTADNIKEQRKGKEQLKCHQCKRNDRKYVVPCTKCCETLYCIQCIKQWYPDLSEEEVAELCPFCRGNCNCNLCLHSNIKMPNMDLTDDEKIEHLHYLINSLLPFLKQIREEQMEEITMEAFVQATTVQHQSLIFIEAVQNAYTSYVLTAVTRYETTILLGFDYIHGGEPLQVSFHENLPTTESNSMIKWVAENNGNIICPPKELGGCNESMLQLKRILPKDWISNLEAKAKLILNKFRNNQQNIVSNTNSLIFRADLYMKAANRKESESDDNYLYCPAFQQGLKGEELIRFRYHWSKGEPIIVKKVLEQTPGLSWEPLVMWRALCEHVDPNVSSKMSQVKAIDCLAGCEVEISTRRFFKGYTEGRQYVNSWPEMLKLKDWPPSDKFEDLLPRHCDEFISMLPFQLYTDPRAGFLNLAVKLPPGVLKPDLGPKTYIAYGMLQELGRGDSVTKLHCDMSDAVNILTHTAEVSISDAQKLAIKELKKRHWYQNIRENTMTVSEHSSNEEQDSKEILISTNEMIQPSGVPLDKTSPKEEEEETGSALWDIFRRQDVPKLHEYLLKYSKEFRHTYCCPVDQVYHPIHDQTFYLTMEHKKRLKQEYEPWTFEQKLGEAVFIPAGCPHQVRNLKSCTKVAVDFVSPENIQECIRLTQEFRKLPINHKAREDKLEVKKMILHAMRQAIADFEELTTSQKSEVLVGQ
The following text describes a protein:
Function:
Hydroxylase that catalyzes the C3 regiospecific hydroxylation on the 5-methyl-1-naphthoate to 3-hydroxy-5-methyl-1-naphthoate in the biosynthesis of the antitumor antibiotic azinomycin B.
Sequence:
MTTEAADATDRLVTAFDHHDPGYTPRTAERINTEIRERGVTWSPAYGGIWILSRYADVRAALTDWRTYSSARGVHFPRAEGMPMFSPIDYDPPAQRGIRERMAAPMTGDAVSAMVPELRRMVARLLAPLAGRGHGDLMAEFAEPFAIEVLGVAFGLSESCRARIREATRTMWTYISADRDASKFWPAFHALLAEEVERVRDEPDGSYLARLAAMRRDGSPLPDEELYSIIVSFCVAGHDNTMNSITRLVHTLAQDPALQLRLRREPELRPAVAEEALRRWCPTDRFTRVTTREVTVAGTVIPAGARVVLLFDAANRDPEKFPDPDTFDPDRGNSHQHLSFGHGIHHCMGVHLARAEFAAVLDELSRLPLFDLEQPSDLHFENGRHIMFDRVSVRFRTGEEH
The following text describes a protein:
Function:
Fatty acid desaturase that introduces a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Delta(7) double bond, resulting in the production of delta-4 desaturated fatty acid docosahexanoic acid (DHA). Also acts on the 16-carbon polyunsaturated fatty acids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The cytochrome b5 heme-binding domain acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
Sequence:
MLVLFGNFYVKQYSQKNGKPENGATPENGAKPQPCENGTVEKRENDTANVRPTRPAGPPPATYYDSLAVSGQGKERLFTTDEVRRHILPTDGWLTCHEGVYDVTDFLAKHPGGGVITLGLGRDCTILIESYHPAGRPDKVMEKYRIGTLQDPKTFYAWGESDFYPELKRRALARLKEAGQARRGGLGVKALLVLTLFFVSWYMWVAHKSFLWAAVWGFAGSHVGLSIQHDGNHGAFSRNTLVNRLAGWGMDLIGASSTVWEYQHVIGHHQYTNLVSDTLFSLPENDPDVFSSYPLMRMHPDTAWQPHHRFQHLFAFPLFALMTISKVLTSDFAVCLSMKKGSIDCSSRLVPLEGQLLFWGAKLANFLLQIVLPCYLHGTAMGLALFSVAHLVSGEYLAICFIINHISESCEFMNTSFQTAARRTEMLQAAHQAAEAKKVKPTPPPNDWAVTQVQCCVNWRSGGVLANHLSGGLNHQIEHHLFPSISHANYPTIAPVVKEVCEEYGLPYKNYVTFWDAVCGMVQHLRLMGAPPVPTNGDKKS
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
WRWLTTGLVFLLSYHVVRFYRKVSKYPEGPFPLPLVGNILSDETQLFKKVGEWSRKHGDPFTLWMGEKPMVMLSSYPVIKEAFIDKRHDFSGRIQLKLAALRLRGNHGIVFEDYNATWKALRKFALIAVRKYAMNESLETLCTGVVDAYVESLKKGDNTVDCKESFMFIIFNIIGTSVFGTKYDKEGPELARLKEINEAFSEEAPNGLPSDVVPWLGILYRKREKKIERLFAEFIDILEGLYTRALESYVPGTIQNFAQSMLVAREEAIGQEKGDAQYLTEGNMIQVLFDIFAGGTETTIGTLQWLCLKMTREPEIQLKIQKEIEDNLGEAPPTMKDRDKLPYTVACIYETLRFYPVAPVGLPHKTSCDTEAGGRFIPKDTALLFNVYGANHDPALWEDPDAFKPERFLDPSTGKLNLEGLPPILTFGLGPRTCPGEKLAHMDIFYVLVRLMQRVSCSVPAATMNKDIKKMDSNLFLVPAAQDIIFTRRD