lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable lipase.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MRIFSFGLRTCRDYASVVLAWFLVYVELCFRLILALIPRVIRGRMRKAVRTLYDYFIFSKSGSGMTGVIQRCRNIYEICEAFGYIAEEHLVRTEDNFVLCLHHIVNPKLRNTSGKHRGVVYFQHGLMTNSELWVAVDKASNCLPFALVDRGYDVWLGNNRGNKYSRKHVRYSPNDEEFWDFCIDDMAMFDIPNSINYILSATKEKSLSYVGFSQGTAQAFAALSINPTLNEKINLFVALAPAFTPKGFSNELLDYLVKVNPKIMFRLFGRGCLLPSVTFWQNICYPPIYMKIVDISLKMLFDWNLANITQEQKICGYAHLYSFSSVKSCVHWLQIMQNSRFQLYDDDLKVIGGYDSRHYHVAHFPTRNIKCPITVVWGKEDTLVDMEIMLAALPPQSKDFGIDGYEHLDMLWAKDVKEKVFPIVFSSLEELNRKRPLLCNASPIGNCD
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSNPISRIFFRFLAGEKAIMPEHLRFARDVATRSPPKPHLPEGPAHKVSNNAYYMRDNRRAARPVVRDRLSTSAQPSRHPVALMIALQSVDPHRQHNTHTFACCA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKAEPVSREDSDCSIVFPLIQRQVNETSADLGSNVKGGLLANYISDDITEEPCSWNEDSSTSIEHQPTDIIGLKHGAAGYLSIMRGAASRDKRAPPNTDISIADHLPDCLSNCSNGEASPWEIEGEPSDFNSNTRTEQPRGTEPSADTMGTSLTDSLLAENCTEYNKVIESASPMQAEVQSFTCYECGKCFVSQRDLFKHLRIHTGKKTFLCSKCGMCFVHQIDLHRHMKSHKGDRPFSCSVCRKRFHSQSDCNRHRIIHTGEKPFACSECGRRFGFLSSLRRHFSLHMRKEQFSCVHCGENFVLQTHLNNHLRIHVTKKSCSECGKCFAREIGLNRHSTTHAGRKQLSCSDCGKDFGFESDLHRHLRTHKEKKALSCPECGRGFECERDLSRHLRIHDEKKPLSCSHCGKNFQCQSELKRHFRIHTGEKPFSCSKCGRCFGFLSSLRRHCRTHFKKAVAI
The following text describes a protein:
Function:
Only enzyme known to utilize 5-formyltetrahydrofolate (folinic acid) as substrate. Contributes to tetrahydrofolate metabolism in an alternative way of folate biosynthesis. May regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
Miscellaneous:
MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MATKQLLRRQIKRVINALDYDIIAAESHTISQAVRSLIASANSRRVACYMSMDKGEVTTGEIIKNLFQDGQEVFLPRCTHTSESKHFKLREDHHPHLIFHRMSSLKMVRDLKPQGPYQLKEPEPHIEESDILDVVLVPGVAFDIKTGARMGHGAGYYDDFFQRYKILHEGQKPLLVGLCLMEQVASPIPLEKHDYSMDCIVCGDGSIHWFQ
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MAFIYCNLLTPVVPAYTYIVQPLVTPTVTNQPLEMKQEVKDLDVFEAEIKQEPLDDWPTVLVKEEPIEEPEKCKEPENAERKVFTCSHCPYTTSWKSNLRKHIVSRHTSSDQIKWLQCSQCSYRGKTRDYLKCHLIHVHNISVKWYNCPQCPFKAKIKRLLDRHLTLTHTDSEKIQWFQCEQCPYKARFSANLKQHKLSKHTDASAINWFKCDLCDFKAKRKRNLRLHQLNKHTNEDKITWFCCNICEYKFKRKQALKAHLTKVHSNAKKKMETREIPVFIDNQLCWRRVVVEREATEAGFKCNQCAFATCDKVLFKQHVLKAHTVTEIKKEDDCIVKQTFKTKDVVVMVDDVPCIKKVIDCPL
The following text describes a protein:
Function:
Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.
Sequence:
MQQIRGSNLRNEQCEFKDAPIRCERGHWYWEQAKQGPFPLGERRSLCLNKASRVVGHFIRIRVSGFIVFSLVWFGCGGIEMATWIRAVQVLGRRVGVRPLVLESERVTARRLISKSASKDGGSGVGAVGVMHQGWSFSDRNAYSSLLMSPLPQRGAQRRGMFIQVESTPNPQSLMFYPGKPVMEVGSSDFPNSRAAMASPLAKSIFIVDGVVRVFFGADFVTVTKSEDVSWDILKPEIFAAIMDFYATKQPLFYDTQSQASDTAIHEDDDETVAMIKELLETRIRPAVQDDGGDIEYRGFDPESGIVSLKMQGACSGCPSSAVTLKSGIENMLMHYVSEVKGVQEVHDEDSDEETNAAG
The following text describes a protein:
Function:
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDLEEAKEFKERCTQCAAVSWGLTDEGKYYCTSCHNVTERSKEVINTGAIPNTKIQAINRGLKRKRKLEKGWDWYVCEGFQHILCQQAEALQTLGVGPELKDEVLHNFWKRYLQKSKQAYCKNPVHTSRRKTTVLEDNPSHSDWDSEPELLSDFSCPSFVESGAESQPDVHTQKPFRIIKASHSETSVCSGSLDGVEYSLRKDKDIVKMTVPRTLAFCYLSLLWQRETVTLSDLLRFAEEDCIPYINAFQHFPEEMKLYGRDKGIFAIESWPTYEDIYKKVIEVATFLDLPRFPAITEDCYLHPNILCMKFLMEVNLPVEMHDVTCQVVKVTGIGEVDFLTFDPIAKKGKAVKYDVQAVAVVIAALKLLFLLDDSLEWSLSNIAEKHNEGNKEDKPWFDFRKWYQVMKKAIDEKKQKWEEARAKYLWKSERPLYHSAIDKPVVYKRREMVVSLQKQFSTLIDSTPSVEKRSPSSFQFNWTAEDSDRTCFHEHSLQGVLKQKGQSLTTKNSLYWLSTQKFCRSYCKHVTTYEESNFSQSYQFILNLFSFLLRIKTSLLHEEVSLIEKRLFKTKYTKTTKKSSRSRKARKS
The following text describes a protein:
Function:
Voltage-gated chloride channel involved in high-concentration salt taste sensation. Depolarization induced by high NaCl concentration may trigger the activation of TMC4-mediated chloride influx into taste bud cells, helping the return to resting potential. Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride. Involved in pH and temperature-dependent modulation of salty taste.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEESPREAWAQFPAWSSSRKARTGPSLASVLNDLPSAATLRYRGPGVLPWGTLDENDDEGRSLQAFAETAQMESQPSRELPWPMQARRAHRKSQAREQVASGSESRAAYWTQQLSRTKGKMKEGFQTIQPWAWTLKKIGGQFGAGTESYFSLLRFLLFLNLGASVIEVCMKLIPTWLEGAPPGPPGPNISSPCGSYIPHTQGLVTFPTQLFNLLSGEGYLEWSPLFYGFYPPRSNLAITYLCSVFAIGLIYLLFILHRSVSGLKETLLAESDVLTSYSHRVFSAWNFGLCGDMHVRLRQRIILYELQVDLEEAAVRRRATEQTLGQRVKVWSMRALLNLLVLALLGAAFYGIYWATEYTVTLQETPVVQQTPLLKLLVNYLPSIFISVFNFVLPPAFTFIASLEGYTHSRQIVLILLRTVFLRLASLVFLLFSLWNQITCGGNMEAEECKACGYNYKEIPCWETRLGQEMYKLVLFDLLMGLLVTLLIQFPRKILCGLCPGALGRLSGTLEFQVPDEVLGLIYAQTVVWVGSFFCPLLPLINTAKFLILFWLKKITLFSIYSPASRTFRASTANFFFPLVLLVGLAISAVPVLYSIFLIPPSKLCGPFQGKLSIWAQIPESIESLPQTAQNFLYFLGTQAFTVPLLIVSSILMMYTVALANCYGRLISELKRQIETEVQNKVFLAQRAVALSSRNGVS
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates 'Lys-10' of histone H3 (H3K9me3) in ovary. H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MSGQPTAVDCLESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQAAKDVEIEELTHSEAIAATGSTRKQCPYGGKAPDEPGKLADESEDRKGENTKAIASSPVLVAVDSDSSVELIESPVKFSSANESEKDPPKPDAVNEAAAKEAEEMTDSSISSPTSESFPEKDEKTNKENEQEPPGMEVDQDVEESISRPAEEYKIENTLKGHKRISLTEIEEHKIVDKKDDVLEVELEKGTAPKAAEDEKLNALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTTADKMHCALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRLL
The following text describes a protein:
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (By similarity). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity).
Domain:
The CARD domain mediates a direct interaction with CRADD.
Sequence:
MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSLPFSVCESCPPHKQSRLSTDTMEHSLDNGDGPPCLQVKPCTPEFYQAHYQLAYRLQSQPRGLALVMSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT
The following text describes a protein:
Function:
Major protein kinase C substrate of platelets.
Sequence:
MEPKRIREGYLVKRGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDMKKAIKCIEGGQKFARKSTRRSIRLPETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMIASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIKAIQMASRTGK
The following text describes a protein:
Function:
Involved in regulation of Ty1 transposition. Inhibits Ty1 transposition at a post-transcriptional and pre-integrational stage of the Ty1 retrotransposition cycle.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYSNHNLNSDDCCFDWNEEKAAELQRTGVSFDRSLTPQSLRTSTRRLSEENKQQSGTMHIDTSPSVVSDIISSRRDRSQDFFGPHSSSPIAPSERQRADQRSRLESMRLTRRRDKMTKVRGGLEKMEEMIMQGEHLREMQRLKQEAQKNALPSDMAEYMEWQNNEDLEDDELLAFIEKQETYKNELEHFLNNANKNVYENNSYPNSHT
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MKPAVDEMFPEGAGPYVDLDEAGGSSGLLMDLAANEKAVHSDFFNDFEDLFDDDDIQ
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MSLNIISKLISSNNLCSRFYLLSRQRNCTYKLHISNTVQFHSNLSCPLLSKKSNLTESKIVENKKPASVLSAEQKFKQTSKDAGYSGVIIIGLGITGFMFYAVGRELFSSQSPNGIYTKAYKMCKQNQQVQDILGEPIRAYGELNGRGRRRYVRFNEFEEAGIQVMNIEFYMEGPLEKAKVFVEARQNHRKKYEISLVVFENSSYPRRVVTVYNEKEIITSSSNV
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MKDPVIVSTGQTYERTCIEKWLEAGHKTCPKTQQNLTSTVLIPNYVLRSLIAQWCEANGIDPPQRAGRPTSACTPAERSLINVLLTKLKSVSPDDQRTAAGEIRLLAKRNADNRVAIAEAGAIPLLTHLLTAPDSRTQEHAVTALLNLSICEDNKGSIVSSGAVPGIVQVLSVIDENKVTIGSLGAIPPLVLLLSEGTQRGKKDAATALFNLCIYQGNKGRAVRAGVITTLMELLTEPQGGMKDEALAILAILSSHPEGKVAIGKSDAVRVLVEFIGSGSPRNKENAAAVLVHLCSGDNKYLVEAQELGVMGVLVDLLHHGTDRGKRKAAQLLEKITRYTEQQKLSQTLSQAIAESEE
The following text describes a protein:
Function:
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Is also able to catalyze acyl transfer using various nucleophiles as acceptors and several acyl-CoA thioesters as donors in vitro; preference is observed for saturated medium chain alcohols and long chain acyl-CoA thioesters.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Domain:
Consists of two structural domains that are related to each other.
Sequence:
MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME
The following text describes a protein:
Function:
Involved in the degradation of (+)-camphor. Catalyzes the lactonization of 2-oxo-delta(3)-4,5, 5-trimethylcyclopentenylacetyl-CoA (OT-CoA), a key intermediate in the metabolism of camphor. 2-Oxocyclopentyl ethyl acetate is also a good substrate, as is 2-oxocyclohexyl ethyl acetate and methyl-substituted cyclohexanones, but free acid is a poor substrate.
Sequence:
MSNRAKSPALDAVVIGAGVTGIYQAFLINQAGMKVLGIEAGEDVGGTWYWNRYPGCRLDTESYAYGYFALKGIIPEWEWSENFASQPEMLRYVNRAADAMDVRKHYRFNTRVTAARYVENDRLWEVTLDNEEVVTCRFLISATGPLSASRMPDIKGIDSFKGESFHSSRWPTDAEGAPKGVDFTGKRVGVIGTGATGVQIIPIAAETAKELYVFQRTPNWCTPLGNSPMSKEKMDSLRNRYPTILEYVKSTDTAFPYHRDPRKGTDVSESERDAFFEELYRQPGYGIWLSGFRDLLLNKESNKFLADFVAKKIRQRVKDPVVAEKLIPKDHPFGAKRVPMETNYYETYNRDNVHLVDIREAPIQEVTPEGIKTADAAYDLDVIIYATGFDAVTGSLDRIDIRGKDNVRLIDAWAEGPSTYLGLQARGFPNFFTLVGPHNGSTFCNVGVCGGLQAEWVLRMISYMKDNGFTYSEPTQAAENRWTEEVYADFSRTLLAEANAWWVKTTTKPDGSVVRRTLVHVSGGPEYRKRCEQVAYNNYNGFELA
The following text describes a protein:
Function:
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Sequence:
MDDKPNPEALSDSSERLFSFGVIADVQFADLEDGFNFQGTRRRYYRHSLLHLQGAIEDWNNESSMPCCVLQLGDIIDGYNAQYNASKKSLELVMDMFKRLKVPVHHTWGNHEFYNFSREYLTHSKLNTKFLEDQIVHHPETMPSEDYYAYHFVPFPKFRFILLDAYDLSVLGVDQSSPKYEQCMKILREHNPNTELNSPQGLSEPQFVQFNGGFSQEQLNWLNEVLTFSDTNQEKVVIVSHLPIYPDASDNVCLAWNYRDALAVIWSHECVVCFFAGHTHDGGYSEDPFGVYHVNLEGVIETAPDSQAFGTVHVYPDKMMLKGRGRVPDRIMNYKKERAFHC
The following text describes a protein:
Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Subcellular Localization:
Membrane.
Sequence:
MAPRGWPGSLLHLLLCWSVYGMVPEPKNLRLHSVMFDSVLEWDPPDFHKENLVYTVQYKTKISDVFIDLCRRIVSTKCNVSHIPAYSSSTIQVRTEFENEYSNWENVSFTPYRETRIGPPAIQVEATKPGVLNVQLIEPSFTLNDGNRSLKEFYGIAIYRILIWKKYHNTEQVQEVNTTDTFQVIRDLDPMTTYCLKAQAFIAELYKDGQWSEPICTNTTDTGLHPGLLTVTILLVLISFPFFSLIIFYIYRWIKYTFFPSYSLPQHFKEFLSKPSYGSQFLMSHSQEEEHAYNKIIVLSEESKNDASECEIQLSNAEQHLEQSQEENYKPKEDSGCISLIHT
The following text describes a protein:
Function:
Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQAEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIRSASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVDFLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRERNAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKGEMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDLRAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILLGKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLFFITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWIELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (By similarity). Deconjugates SUMO1 from HIPK2 (By similarity). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (By similarity). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (By similarity). Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity). Deconjugates SUMO1 from GPS2.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
Sequence:
MDDTADGVKMDAGEVTLVNHGSTFRTHRPPQSGFPEEQLLLSDQQSLPFRQGTLDGSFTCSTRSPAYRPDYHSDNPSSDSFLGSGDVRTFGQSANGQWRNSTPASGSAPQKPRNSRSLCLETRKTSSGLSNTFVGKSNHHCHMSAYEKSFPIKPAPSPSWSGSCRRSLLSPKKTQRRHFSTAEETVQEEEKEIYRQLLQMVTGKQFCVAKPTTHFPLRLSRCLSSNKNSLKDSLLRNGNSCASHVIGSDTSSSGSASILTAQEQLSHSAHSLSSGTPDVAFGSKDSDPHHHLAAPHQPNSLPASNTQSEGSDSVILLKVKESQTPASSPTFFQAELWIKELTSVYDSRARERLRRIEEQKALALQLQNQRLQEQEHAVLDSVELHLRVPLEKEIPVTAAQETRKKSHQLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGFPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRRKSITYYDSMGGINNEACRILLQYLKQESVDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
The following text describes a protein:
Function:
The pharmacological activities of caerulein are quite similar to the physiological activities of gastrin and related peptides.
Subcellular Localization:
Secreted.
Sequence:
MFKGILLCVLFAVLSANPLSQPEGFADEERDVRGLASLLGKALKAGLKIGTHFLGGAPQQREANDERRFADGQQDYTGWMDFGRRDGQQDYTGWMDFGRRDDEDDVNERDVRGFGSFLGKALKAALKIGANALGGAPQQREANDERRFADGQQDYTGWMDFGRRNGEDD
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRYEVRCEHSLANPELFRSASRDDPEGLLEGVAMAGLVGIIRQLGDLAEFAAEVFRDLHNELVTVGGRTHDLTVRVQSLEAELPAVERALLSEPNQLRFAYTNGADWHVSIRSDQNHCTSGELPRFIRNFYEECRGPPRLFLLDKFDVAGAGACLKRYTDPSFFKVEWASSELMKAQRAQRERKARRDKKKGRRRKTGQPIAAVTQIPARVRYGSASLEDLDTFSHLLASTLKDEVPSSHSVSGASHGHGSQAQAQRRSNLGPKNRVAGGQLPSTGVLSPQAEGVSSTPLKISAKDIEANISRKFYHPIEPGNAAESQGGKISKIIEMENRDSVPSVGLIPRSGDIKSPKGANESKVSPSDVEAKETNRVVREDLEVGAIPHIENDLQEISRGDASMEELQGSDFGRASKINTADIPSREDAAVDDKEGVNIVDLRSLSDSAVIGSGFSGSQANSSTSSGGPSISDVDLANAQVSSTSGGLSGASSTAEEFVSLARGSDPVHGLDEQLSYSSTEPPAGVRAPSAAAFEVEGLPASGDPAFHDDHLSKIKRVHNNVMDSSEASRNAEETVYKEPYLPPIRIEEVFDDEGSRTISAASPTPSSQCSSQREDIQPSNSMLSRLSYSSELASVSSGSELASPVSSKSPAFNALYSPSRSPRISVDITKSPPGIYSRPARRSDRGSPRSGTPVLSSSPEPPSASVWTDGEDHAGPSRPPPPPTPVTVIETGSHFDSDQETNSVEPRFYPSPSPRANLKSGSEPDSVPLQPNEGSGYISNLSENAGNLHAESESSSLGNLELKHKPYSSEDLKTPSEPASAHMGTEVPYRSTPLTSLTSDLRSGTGLDEAGPSSELRQGPASNPAFANFVRSSLILPPHPSESPASSVHTSPLGTPKHRSQCIFVTNPSVKFAPSPLGQVASYDSHSHSVKDEESLPSSPTGSVIIKDTPSPPGSPASNYSENESEIHEFQSHSRAKSPVSPRSVAHALEDDHDERAGSNTGVPQDPRFTSSQSGQPIAGSVQEAGLVKAASENIDYRADSPPEGRVDAPLTRISPHHGMAHEASLQASSPISMQLDSGRTSPFGGMDAADLRPILTTRLSPKSRNSSASNSPPDSPPLREYLAGEDEDSAFQWAGRSQTDLPSKMEIGVSPGSEASNSPPTSPPKFLDRASSLKWRGRSESASLYPDSSLPPNLVCRSEISSPSSSPPPQSDMESPKEWDEGSLFSDSSDSSEETAVEVAVSEVYRLPDSPLPPDSPTMSEEDDHSSGPSSKPEFDEDEDTTVDHEHDIVRTTATSASQHPSDSSSSALSKGSDEVLSGEPKVSNDDSQIRDAQLGTSTFGSSTPSFLPVTLSRLDTNQHPMKINSTTQAQESPPSPAAPEPTINPTKDPMATAAQHNWNLIKALTFQDPGHSKLLQSDERFIMQDQTTKYFDLRRTESTEKKVPLIRPSANINVAAILEKANAIRQAYVGSDGEDDDEDDWSDS
The following text describes a protein:
Function:
Required for bud-site selection and cell separation. Also involved in nucleolar processing of pre-18S ribosomal RNA.
Miscellaneous:
MISCELLANEOUS: Present with 16700 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKSDFKFSNLLGTVYRQGNITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLLIYSTNDTILFDPFDLDVDVTPHSTVEALREKQFLNALVMAFRLNEEYLINKVYEAIPIKEIPLVASNIPAIYLPRILKFIGDFAIESQHIEFNLIWIKALLSASGGYINEHKYLFSTAMRSIQRFIVRVAKEVVNTTTDNKYTYRFLVSTDGSMEDGAADDDEVLLKDDADEDNEENEENDVVMESDDEEGWIGFNGKDNKLPLSNENDSSDEEENEKELP
The following text describes a protein:
Function:
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Sequence:
MKCLEADYEMLSSKLAETTHKFEETVKSADESEKQRRILDHKKDIEDERLATLEKFIRETSDAAVESEKKCDEIIKKLAVTDSDSELAHQRYDIAEKKSKELQAEIKSIASKLKAMQSKLENADELEDKYERTIDDLRARLRNIANTNSAYAGDLLKKKIHFCRIFHIVVFYLSFQIRVSELEYFKGPEYPTLENVY
The following text describes a protein:
Function:
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein; [Isoform 2]: Endoplasmic reticulum; [Isoform 4]: Endoplasmic reticulum.
Sequence:
MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWRLFFLIMFLTIIVCGMVAALSAIRANCHQEPSVCLQAACPESWIGFQRKCFYFSDDTKNWTSSQRFCDSQDADLAQVESFQELNFLLRYKGPSDHWIGLSREQGQPWKWINGTEWTRQFPILGAGECAYLNDKGASSARHYTERKWICSKSDIHV
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Domain:
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MEISDILFDDLVVGEINDDFICVICSHLQVDIYQCVEGHFACKNCFLKMIELKKQCMTCRCEIKSIESLSKNRYLEKEVRKLNIYCPNSFSDLKNSIKDENACKDIITIEGLETHLKNCKFTLKECPNNKNCNDDNKNKECLKIRQGEFDHHLKECPNSLIKCEHCSIEITRSKQTDHIENHCLKVLKQCEFCFKLIERGEFNNHQDTICLSKLIKCPFNEGGCVDLVKRSDIKEHLSVLAGEHLLYSITMINSLSLKLEKSNSELQESISYSRLLKKDFKELKKSKSYSGRWVIEKWSEKLKQYGKGQSIQFQKFNTSTSPSSAFSYFTLRLFPNGQYNGETISIHLVKLFRNKSRISFSFEIENHINPSSNEEIDSRFLFGNLNDYYSTIFYKEYNKENGFISEDDTLVIHFNVEILKYYDDTFITK
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Miscellaneous:
MISCELLANEOUS: Present with 1890 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MVDLEQEFALGGRCLAFHGPLMYEAKILKIWDPSSKMYTSIPNDKPGGSSQATKEIKPQKLGEDESIPEEIINGKCFFIHYQGWKSSWDEWVGYDRIRAYNEENIAMKKRLANEAKEAKKSLLEQQKKKKLSTSLGGPSNGGKRKGDSRSNASISKSTSQSFLTSSVSGRKSGRSSANSLHPGSSLRSSSDQNGNDDRRRSSSLSPNMLHHIAGYPTPKISLQIPIKLKSVLVDDWEYVTKDKKICRLPADVTVEMVLNKYEHEVSQELESPGSQSQLSEYCAGLKLYFDKCLGNMLLYRLERLQYDELLKKSSKDQKPLVPIRIYGAIHLLRLISVLPELISSTTMDLQSCQLLIKQTEDFLVWLLMHVDEYFNDKDPNRSDDALYVNTSSQYEGVALGM