lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Potassium channel regulatory subunit that modulates the delayed rectifier potassium channel activity of KCNB1 by namely slowing down the deactivation and inactivation time constants. While it does not form functional channel on its own, it can form functional heterotetrameric channels with KCNB1.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVYGEFFHRPGQDEELVNLNVGGFKQSIGQSTLLRFPHTRLGKLLKCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQEKKEESPDKDWENKSNAGSLDSSEEESSIFEKELEKFDKQCFGDLRKKIWVTMENPASCLSAKLIAVSSLSVVLASIVTMCIHSMPEFQKLDAKEREIENPILEVVEIICIVWFTSELMIRSAAAPSQKKFWKNPLNIIDFVSIIPFYATLAVHTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLAVGISIFSVLVYSVEKDDDTSELQSIPICWWWATISMTTVGYGDTFPVTFMGKIIGTTCIICGILVVSLPITIIFNKFSKYYQKQKDMDVDPCNDDPKEKTNELPYFNIRDIYAKKMHSFISSLSSVGIVANDQDSTDASSIQDLDDVYNATSFQNERASLVSSKTHL
The following text describes a protein:
Function:
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Sequence:
MDTLNVKGIRAYGYTGYFDAEQFLGQWFEVDLTIWIDLAKAGQSDDLNDTLNYADAVAIVQKLIRESKFKMIEKLAEAIADAILGTGKTQQVKVALTKCQAPIPDFDGDVTLEILRSR
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Sequence:
MDPNGEHSPLGFLPCYKPPGATSRDLVNRAQRRLRGEFGLRKLKVGHTGTLDPLAEGLVLLAIGSAARLTPWVLQHGKRYLADFRLGVSSESGDLESELVTQTDVKLPTAAEIEQVLKDFHGVVEQTPPAHSAIKVDGERAHKRARRGEDFEMPKRRILIDSVKLISYEPPMMRLDVRCGSGTYLRTLGMDVAAACGCAAVMTKLIRNEVGRFTLDDTLDCAFMFDDDDREKMSSEPMVKYLRPAIEGLTHMPAMNLDRQQIGMLQAGIRISGTPEAPSEPLPEAWIGCIDQVDTFDRNTDVLDCIGVDRSDGSSGPWGELVAILRPHGKLWHPLRVFPTTESITLRG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSGTPGGGVQTPAIPVPQGLPPLGLTMPGIQTPNPGPGGNMMGVAQAGGMQMVPMQPMAGGGGGGGGASISLGLLLEHLVQKTYHELTVLSELLPRKMDMEKKIEIVKFARSTRQSFIRLLALVKWAGSAAKVDKCAAISLFLDQQSFLLVDTADMLSRMARENLVHARLPNFNLPHAVDVLTMRQYKRMPACIKERIVPPDPITSVEKETVLHRLDQIIQHRLVTSELPPQLANLTIEEGRVKFRVPQEFEVTLTLMEDNKTIPWRLLNIEILVQDPDTGDGKTLVHPIQVMCIHQLVQSRLFGDDKPLVDMYNVIHTFCQSLQLEVLYSQVQRLISERWGEHVTIDKYTAGECLMMSYWRSQSLHASKKPELFKLTVSIDDDDVAKPLQVLHDPPLDMVDAAHVNQAIRCDHLSVERLLVETVLVRSRLKLKGLQEELEKDLPGCKCHVEGSPSLLYIPVVKPCSEDEQLMVSVDMQTGSYIPSIAHCGSTLLDEIDQGLNHERSKLEPLIAKLRVLLYMRHCQYSVSMLPVTFLKELPLVTVSPEHPVNRLLPNYIYLRLTQHPQYYVVVDFALGKGLGDFLCRYHLMRCSSASYIDAQTIPQGGAAPSAQKDTPETTEKYLHPDVFVDLDHSTILRGPDTSVEDLDVDDDEKKRKVHHITAGEHKRKKLTSYCEFFNYTLSHVVSLCNIRIPFIKLCEELSQNNLAHQGIQVEGEGVGLVIKLCSLPPCKGVAKETSMALNAALLDCSFRLHKNQHGMWQVQMVFANCPVTSCSSREQGSTRLVYLFYKVLGSHSVVKQFQRDWDSIGRLYHLTLDLPIWLPYLTLSHSSRSSLIQDNPPFTTLVDIQSFTYQKITIAYGKDRSSTVMVCWDPDILRFRLIFSAVGSTSTANCHTMVQSYLEHELNEEQSLPKLIKSLCESQGPLHAICRLPLIPSLGLIAATNQVAGPIHKFALCPQSSTHYRVVFHNAYCLDIHCKGKNTVAVRDGAFSLFDMRKVVEGLYTVPNLKAFLELFIDETVSYHHQHRNSRTLPANEDDGNPISPMNIDAGPTPPDPYLPTQVSGYPSGASPMSRAGLGQGGSGGFAYPMTPPTAPGGPGSSNPATPASPHTSVLSQQQHYAMSPGAYPLASPPSIPGPSPSAVMKGTPSPGLVEGGSPFTSSMGLTMPSPGSRQWPGSPSMPGPSPVQRFGMAQSPGGSMGPSTHSPGSSGMTGQQGQVVPRQTRVLPPRNLATSLPTILSHEALHRMFTPAAIHGTPTTPLTYLCAPIERFLGSTYLQRHLKRVINAEQTQTLQAAEQGCRLKLTLLPPSDQGFHFKNDSLIFRVWLNPAHMQQLHLQVKQTPDAKERWSPDELHVIELYYENKVACPPFKPKAITSFARMLCAMPGVFKDLIQLMHLELQPDPSLKWSMQLCLTVPQGQTFAPVGIPAVVIKTKMLLFIQLSRQDTAPMVGQEAPSVIVPVLYDMQANTTQHISAIKPSVPTSQNDGTIATMLRRWAEFPNSAECTLFPAIRDLMANLNLPM
The following text describes a protein:
Function:
May function together with HSC70 chaperone to assist protein folding and prevent protein aggregation during heat stress in the chloroplast.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAIIQLGSTCVAQWSIRPQFAVRAYYPSRIESTRHQNSSSQVNCLGASKSSMFSHGSLPFLSMTGMSRNMHPPRRGSRFTVRADADYYSVLGVSKNATKAEIKSAYRKLARNYHPDVNKDPGAEEKFKEISNAYEVLSDDEKKSLYDRYGEAGLKGAAGFGNGDFSNPFDLFDSLFEGFGGGMGRGSRSRAVDGQDEYYTLILNFKEAVFGMEKEIEISRLESCGTCEGSGAKPGTKPTKCTTCGGQGQVVSAARTPLGVFQQVMTCSSCNGTGEISTPCGTCSGDGRVRKTKRISLKVPAGVDSGSRLRVRGEGNAGKRGGSPGDLFVVIEVIPDPILKRDDTNILYTCKISYIDAILGTTLKVPTVDGTVDLKVPAGTQPSTTLVMAKKGVPVLNKSNMRGDQLVRVQVEIPKRLSKEEKKLIEELADMSKNKTANSTSR
The following text describes a protein:
Function:
Transcription factor which binds to the 5'-CCATACATTA-3' motif found in the promoter region of pgp-12 and activates its expression in the excretory cell.
Subcellular Localization:
Nucleus.
Sequence:
MAQVQQVPSSPMNGIPEKNGNGLSIEESASTAVAALAHIQNGAVLFHGTPTKDLNGASTSIDTDDLQLSPSDLRRRSTRASALKAQEKIKLKDDIVQGPQKRANDDDDMEDEELGDEINEQSAPKKRRLENGKEFDQTCFRFGLRANNEGEVYAMTDESENSSIHESEMEVVRYHYEKMKNKEPDEEQLRERLNMRREAENQLREEEAKLLVLRKMKDSQTRAITKLAAETKAADLAEATSAAYKPAVATNGKSVTNGKNSMIESNNKTMNGLKNLSIPQQLELLQKLSSQSPAAKQAYIMAKKNPAQTTQLFQQLITINNQNLQKQKELSAAETNASASASPAVQQSQQAQQPQQAQITQSKLLNQQTPAQRIQAARLAFRAQADKQLTTIPTQKSQPHDITFLPNPNASAFLALHGLDLVVQHVLKDRSNETPYAGPSYECEECKTECAHTWKAIGSTQDDLHLYCENCVRSAQKRKNRTDQTALLKRAFQKITAQEKLLQEFEKKIAEGQLEQYAEAKAAAPATSQTIPTSSTATVSSIPLVPRLPQIPSSTGSSTPTQAVKTSTPIHSTPKSSSSSAKKTAAQLQQQSMQGMNQLFSTAMLRNNPQMQQMLQMYQALAMGGGAANMANNQMAMLFQAQAMQAAQAQVARAQAAKAQAAQAQAAQAQAQAQANREANQQSMLIQALMSNGQVNVQALQQLQKLTPEQQKALIEVVKRQTRK
The following text describes a protein:
Function:
May be required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAGSQQQQQQQAVSKPTGGKHGNNLPLWGNEKTMNLNPMILTNVLSSPYFKVQLYELKTYHEVVDEIYFKVNHVEPWEKGSRKTAGQTGMCGGVRGVGTGGIVSTAFCLLYKLFTLKLTRKQVMGLITHSDSPDIRALGFMYIRYTQPPPDLVDWYDEFLDDEEELDVKAGGGCVMTVGEMLRSFLTKLEWFSTLFPRIPVPVQKAIDQHMKSRPRKPPQKDEQEEEEEEATAAPAADTGRHGDKRRSRTPRRSPSPRKSQNRSRSRSHHRERHGASFDYELERERDRQRKEREGKDRDRDRDRDRERDRERDRDRRRSRTPDRNAERRRSRSRERRRSRSTSRDKRTERKDRDKDREAESERERSRKKDREHHKDRERSKDKRSKGEGEERRHKDDKEEKKHREEKRSKRSRSRSRDRKHKAERSSKKRSRSGSRSRQEAGEEKNRKRERSHSKDRQHKRSRSKERSHRRESSNERIHARQERPSSESGERTNSVRADSP
The following text describes a protein:
Function:
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigE. ECF sigma factors are held in an inactive form by an anti-sigma factor.
Subcellular Localization:
Cytoplasm.
Sequence:
MADPGSVGHVFRRAFSWLPAQFASQSDAPVGAPRQFRSTEHLSIEAIAAFVDGELRMNAHLRAAHHLSLCAQCAAEVDDQSRARAALRDSHPIRIPSTLLGLLSEIPRCPPEGPSKGSSGGSSQGPPDGAAAGFGDRFADGDGGNRGRQSRVRR
The following text describes a protein:
Function:
May be involved in mtDNA stability or mitochondrial gene expression regulation at the post-transcriptional level.
Miscellaneous:
MISCELLANEOUS: Encoded on the antisense strand of the nuclear 25S rDNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MRDSPTHKEQRAQNTMSDQMPFPFNNFTYFFTLFSKFFSSFHHCTCSLSVSRQYLALDGIYHPLRAAFPNNSTLRRHFTKNRTPRHTGFSPSMTSCSKEHRQGTAPKLPSPNYNSGTEGTRFQI
The following text describes a protein:
Function:
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.
Sequence:
MLSYSRHAGVIVGSFVAMVLTQNSIASAASVVTGTPTGFAAGTTGGGDVEPVYPTTIEELSTYLSDDEPRVIVLKQEFNFIDSEGSTTEDGCRGKNNLDCIAKKNGFQGQDTIQTSFSTCDGTTIEVTYDKAAKTPLKVASNKTLVGEGTSGVLTGKGIEIKGNNVIVQNIHITNLNPHVVWGGDAIGISGDDDVIPTGIWIDHVKVTSVGRQMIVVNFSGALGVTVSNSDFDGTTKYSSSCDGHHYWGFIVTGAKTEVTLVGNAIHGMSGRSPKIGGSEDNVIAVHAVNNYVYDNTGHAFDVSQRGYVLAEGNYFDSVKTPNQPDPDGNLFVPAAAGDCQATIGRDCELNVLTDSGTFSSNLEDAAKTQISTYKTQIGGLTVTGASKLSVASDNFGVGALDTNSVAQASGSGGVVATSTDSSAATQGTEAPSVTAAAQETSTPVTTALPSTDSSASAATDASSAHESASTEATEVPAMSGSGSEATESPTPATTDTPATTEAPSTEAPSATGQIQTSTSTSSSSSVVGSATGFAAGTTGGGNTEPVFPTTIKELGTYLSDDEPRVVVLKQEFDFIDSEGSTTEKGCRGKNSLDCLAKKNGFQGQDTIQTDFSKCDGTVMDVTYDKAAITPMTIGSNKTLIGEGTKGVLNGKGILIKGNNVIIQNIHITNLNPHLVWGGDAIGISGDNDAVPTGIWIDHVKVSSIGRQMVVTHFSGASGVTISNSDFDGNTKFSSSCDGRHYWGFLILGKTTEMSLLGNFVHMTSGRSPKIGGTAGDVSVVHAANNYFDDNTGHAFDVATGGYVLAEGNYFDSVKTPNQPDPEGNIFVPAAAGDCQASIGRDCEVNVLTDSGTFASNSEDAATQQIGAFKTQIGGTKVAAAAQVSAATGNFGVGELGSDSVTQQATTTGSSDTQGAMAPTATQSTQETTAPTTTGSSS
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSLDINWSLLSQPDESATDQLSESLIALLNAQLAEAHRPSFIGPITVTAFDFGNAGPDLEVKDIRDVWRVFDQGDDEGDFAEEEKQREKEREERDKLRNEALKSSLDGERYELVDRYSSTEGTSSFEYQPEYDIHEQHGDDYRIRGRRPLSYTFGYPHDRLAVHRSSSSRSFIPFPFDHPPPALHIPSTPGLNPSLVSHPISARFSRRPMSIAASAAPRPTPRRRPIEPSSTSPSPPAHPAGLPPKVSSSSIPSLQLHLRLSHASDLHLTLLTSLQVNYPSALFMALPLKLSITGFQLNADIVMAYSGEKNRVHLTIVDDESNPAHKEDKQIPLGQRLLSNLQIESEIGHADAHVLRNVGKVERFIVDVVRKTLVDELVFPNFHTVAL
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLAKVKHIVLVLSGKGGVGKSSVTTQLALSLSLAGHSVGVLDVDLTGPSIPRMFGIEDAKVTQAPGGWLPITVHEADPSAGVGSLRVMSLGFLLPKRGDAVVWRGPKKTAMVRQFLSDVFWDETDYLLIDTPPGTSDEHISLAENLLQKARPGQLAGAVVVTTPQAVATADVRKELNFCTKTNIRVLGVVENMCGFVCPNCSECTNIFMSGGGEVMANDFGVRFLGRVPIDPQFLVLIETGKRPTYPAGTTVDGKDISTPAGASTSEEEEVKDGSRLVHKYKDCSLAPIFSKITADVISAVQQ
The following text describes a protein:
Function:
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
Subcellular Localization:
Nucleus.
Sequence:
METEGSWGTASGETALPCGLWASRGDTSVNLSGAMGSASPGLSAPPPTRHLLPDTGLRTSLEKGSGAERRGWSPSPPATPEQGLPAFYLSYFDMLYPEEGTWGGKDPVDGGREEAPKEPEQCPIIDSQAQGAGLDYPPGNLTLEEHSLEQVQSMVVGEVLKDIETACKLLNITADPNDWNPGNVQKWLLWTEHQYRLPPVGKAFQELGGKELCAMSEEQFRQRSPLCGDILHAHLDIWKSGWCLCDSHQALPSATAAWMKERTSGALHVCAVGSEETWNNNEVDSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPV
The following text describes a protein:
Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
Subcellular Localization:
Endomembrane system; Lipid-anchor. Late endosome membrane.
Sequence:
MGNLFARKRRSRVTEQDKAVLQLKQQRDKLKQYQKKITLQLQRERELAKQLLHDGKKEKAKLLLKKKRYQEQLLEKTDNQISNLEKMVDDIEFAQIEMKVIEGLKVGNEWLKKMHEVMSIEEVEKIMEETQEGIEYQRQIDEMLSGSLTAEDEEAILEELEAITQEDLELPEAPSEPLSDTVPEKQAVKNRPKPQLVAAS
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MLWHTRRDGVRRLTTLAPLLLVVVFALFCTLACALPSATGDRILVVVDQSAKSTYSNLFASLSSRGYKVDFKAPRDTKPELVQHDVLSYDHLMLLSPASKSLAADLSPQKLVEYLKAGGNMVVGLDSSVSEMQRDLAREFSLEFEQRGSALVDHFRYSSEHDAGNHTAVLVGGKRSARTAGLSGGGLVQNKNVFSQVTLEAVEQSPLLYRGIVHRVGANPLAFPLIVAPATSYSSEVPLLAKEQLEAVESTSYSTPAPVTVTTTKMVEGETVTSVTLSTPRAVATVIKRESTSKLGKDGWVAKKRNSVDALEARKELVAGLGTGSGSTHALVSLVSGFQLASNSARAVFVGSTEMLSDAFFSDASSGSVNQLVVADLTAWTFQEKGVLKLIGTHHHRVKSGATDTRQDYEETQEANKMYRINDHVYYSVDVAEHDAQLGWIGASNQLDLQVSFKMLDPYITAHLAPVDVDSTNSSCVGFNSTGASPAFTRFATTFQLPDRHGVFSFILDFKRTGLSFLHAKDTAPLRPFNHDEYPRFLSSSWPYITGAFSTVTGFLVFCALWLTIRDHPGPAKKNN
The following text describes a protein:
Function:
Exhibits pyrophosphatase activity with stronger affinity for pyrophosphate (PPi), moderate affinity for ATP and ADP, and weak affinity for tripolyphosphate (PPPi). No activity observed toward uridine substrate. Negative regulator of the salicylic acid (SA)-mediated amplification of defense responses against both virulent and avirulent pathogens, including oomycetes (e.g. H.arabidopsidis) and bacteria (e.g. P.syringae). Represses systemic acquired resistance (SAR).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MGQDSNGIEFHQKRHGLLKDQVQLVKRRDSIRYEIVSIQDRLSFEKGFFAVIRACQLLSQKNDGIILVGVAGPSGAGKTVFTEKILNFLPSVAVISMDNYNDSSRIVDGNFDDPRLTDYDTLLKNLEDLKEGKQVEVPIYDFKSSSRVGYRTLDVPPSRIVIIEGIYALSEKLRPLLDLRVSVTGGVHFDLVKRVLRDIQRAGQQPEEIIHQISETVYPMYKAFIEPDLQTAQIKIINKFNPFTGFQSPTYILKSRKEVSVDQIKAVLSDGHTETKEETYDIYLLPPGEDPESCQSYLRMRNKDGKYSLMFEEWVTDTPFVISPRITFEVSVRLLGGLMALGYTIATILKRNSHVFATDKVFVKIDWLEQLNRHYMQVQGKDRQLVQSTAEQLGLEGSFIPRTYIEQIQLEKLINEVMALPDDLKNKLSLDEDLVSSSSPKEALLRASADRVAMRNKNLKRGMSHSYSTQRDKNLSKLAGYSSSDRRYEERNHDSPANEGFMTLLSEQISSLNERMDEFTSRIEELNSKLSCNKNSPTQQSLSIQTEVCNGSAPTSYFISGLDNGCLTNSIMPHSSSSSQLAKDSPLMEEISTISRGQRQVMHQLDNLCNLMRESSAERSRLARTGSSNSGNRGRSSKSSFLSNVESNKLPLVLTVAICSIGIIVIKSYINKRQ
The following text describes a protein:
Function:
May inhibit cardiomyocyte growth.
Subcellular Localization:
Secreted.
Sequence:
MHGSGSLLACLLPPLLLLGAAPGPAGALSEEEKHVMVELHNLYRTQVSPPATNMLQMRWDEELAAFAKAYAQQCVWGHNKERGRRGENLFAITGEGLDVPLAMEEWHHEREHYNLSAISCAAGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIHLLVCNYEPPGNVKGQRPYQEGTPCSQCPLGYHCKNSLCEPIRGPEEAQDLSSLVPEAPSSLATEASSSRREGIDSSLATEPPPFLVTEVSGSLATKVLSSVETKAPSSLVTEDSPSMATKTPLSLATKVPSVLATHSLLSLDKRPATLLPKSTHDPIPKSADKEASSTRMPSRIPESSLHPKISLMGTREPLPLSQEEGEAEAELAHCSEILASVFPAQEKPGELQTTLKHKGHSSSKSLSNSPSASATANAVGGRTLALQSSLPDAEGPGKHGFRSGSNASPGHVGGLLLGLLLLLPLVLAGIF
The following text describes a protein:
Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MASAKAITDFFPPAKRSKVVAAAASSLESSSKKSILSVSQKPTTNAVPFPSTTPESVDGSGVQLSPSSNLNEEQKLRVQFNQSLAKAKRNLKICAGRVSKSTSGEGLGSMKLEELLVEETWLEALPGEFQKPYAKKLSEFVKAEIQSPIPIYPPQHLIFNALNSTPFDKVKAVIIGQDPYHGPGQAMGLSFSVPEGIKVPSSLVNIYKELQQDLQCLIPSHGNLERWAVQGVLLLNAVLTGKTKTLELSEWIKSKETPLYIILFYSVRQHQANSHAKKGWEQFTDSVIETISRKKKGIVFLLWGNYAQAKSRLIDESKHHILKAAHPSGLSAHRGFFGCRHFSRTNRILEEAATSPIDWQL
The following text describes a protein:
Function:
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYDTSDLCDIYHEEVNVVEPLFSNFGGRTSFGGKITTVKCFEDNGLLFDLLEENGLGRVLVVDGGGSVRRALINAELAELALKNEWEGIVVYGAVRQVDDLAELDIGIQAMAAIPVGAADEGVGESDIRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
Sequence:
MSMLDKADGKIFTGNVRLVHAVGMHARPAVKLTKLAKKFQAQISVRVAGAAEWINAKSVVKIMAMRAAHGSTIEIRASGSDAEAAVAALVDLIATDFPDGA
The following text describes a protein:
Function:
Lipid binding protein bound strongly to phosphatidic acid, phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate. Binds actin in vitro. Involved in trafficking and modification of clathrin-coated vesicles.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Cell membrane. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Cytoplasmic vesicle.
Sequence:
MEAIRKQAAKLREQVARQQQAVLKHLGHVNADAVVVDEEELHCHQKLQDLYSSTKAAKRLQRNIVRGLEGFIATGTKVVEIGLKFAEDFKKYGDENPDANTPLSRVAHHFGTSYKSVEGERETLLGVLSEQVCEPIRTMIYSAPLEDARHLVNHYDRLRQEVEAQATDVLRRRSKLKESDISEEAYIKLKNSESRLAELKSSMKTLGKEATKAMLEVDDQQQNVTSQRLRALVEAERSYHRNALDILDKLHSEMIAEEEAIGSSPKSLPLHIEDSASLPQQEPNSNSSGEIKSNPLGKIKASRREEIKSNPQEVTKPSPKDEMKSSPQEETKSNHQKEIKSSPQEEIKKSNGSDDHHNHQLLSQNDSYFLAKVVHPFDAQAPGELSLAVDDYVIVRQVAGTGWSEGEYKGKAGWFPSAYVEKQEKAPASKIVESNSKQQ
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Sequence:
MWTTKEFVGGPLKIEDPFPTNFSSQLMNIQFYLPTNCIPKKSSETSLKSFANLQKASSQLNLFTNMSWRFFRPMHLAFAAIVAVAICFPGCANGMSAERVIDSPLLTEKISTNRTIKVDLNGNGDFTSVQEAINSVPKGNSQWVIIHLRKGVYREKVHVPKDKPYIFLRGNGRGRTAIAWSQSSVDNKASATFTVEAKHFIAFGISFKNEAPTGIAYTSQNQSVAAFVGADMVAFYHCAFFSTHNTLFDYKGRHYYDNCYIQGSIDFIFGRGRSLFHNCEIFVLQDKRIKIRGSITAQNRGSPQDNSGFVFVEGKVYGIGGVYLGRAKGAYSTVVFAKTYLSRTIVPHGWTDWSYHGGSDHLFHAEYDCRGPGADTSERGHWAKQLTEKEAAYWTSIDFINGKDWLPVWL
The following text describes a protein:
Function:
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Sequence:
LLSSVLSAAAARGASTNEPSTGRMERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MLTGRESLVRLIGRRRRSPLPASLAAVLSPSCPLPSASPAQADDGGGPGEAAGVEAGSSYGGSGGVGVRAEWVSCPVCGESIRGSDYCVNTHLDICLTRGTKRKLTQSTLLNFRFSKKVSAEPTSNNLTNEVETESVKQIDEDLSRNQEFISLDSDTESSKAGATISSSGCLNGSFRTSKTISTYAPSNTILPDVKDEHCSSSMLPTVATSCSDDACADLDSSTTITVDTVIVGRRFHENIELREDAGITFLRDPQNAKDSDAIKVLYAASECEMLGYLPRELAKVLAPLMDMHYVECEGCVVGLPEQQLGNVPIQITIQKCKIDNQINDDPEYWQSLWEKFISTVKSGNFQRPSSARYQRNFNLMIADVMANHAHVFSDIERSFLASFKSLSDDGQRLFVRIYTRKGPWFRKSTISYREISDLEHAVMELKLAGYINMLSCTVDPSEYDMKEILDVLSVPEIKEILKELPKENTSCIRRHELACTLLSLYHNGTCASLPKRILKWTGTCIRISKMADELLWRIQAIRVAQLMDESLDNNNMDLVTRCIDLSENRLCTMPKQENATSPEHSPSFFSHFSASWVYSKILTLGVSVYERDRRYEDAIRILKILLSKVACDRRRGYWTLRLSVDLDHMGRPNESLSVAEGGAIDPWVRAGSKFALQRRVLRLSKPPRRWKVPSYADYVKRNIKEMNIEGRPLNCETGAKNLFYGYDGELCGVEQLALQYYADEGGGWRGTHSEGGIWMTIFGLLMWDVMFSDIQDVFQSKFQTAPLDLETDYFYKSRKDLAESQLKKIQEGMAEEMLISSWELHQGTSCRGVNWDRHSLTDLRAVVACIGGHRLALLLRHLAVDYRSWSSGMPDLLLWRFLDERGGGEAKLVEVKGPRDQLSEQQRAWILVLMDFGFDVEVCKVSPVTKRR
The following text describes a protein:
Function:
This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Sequence:
MDKNKKLQSKRLRRRRHVRNKLRGSADQPRLCIQRTLKHFACQVVDDQAGKTLLSASTRDKTVRDQVKAGGNCDAAALVGKLVAEKAAEAGVKTVKLDRGHNKYHGRVKAFADAAREAGLQF
The following text describes a protein:
Function:
Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MNTGEYNKLGSAIEEVSRGQLGRWECYKQRLFFLVLALLVATVLWALILSTLLSSASSKLRVLLSHQDLLRTNASEQKMTLSSLKDDIGACRNCCSVTKAQLQTTLAEFKDIQAKLMEQESILKELQERVTQDLAKASRDRENIRSELFQALEAVKRQNSSCEQCPPSWLPFQGSCYYFSETQATWDTAQSYCGGQGAHLVIVRGLNEQGFLSQHTRGRGYWLGLRAVRHLNKIQGYRWVDGASLNFSHWNSGEPNDSRGHEDCIMMLHSGLWNDAPCTNERDGWICEKRSSCY
The following text describes a protein:
Function:
Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by promoting decapping and leading to accurate 5'-3' mRNA decay. LSM1A and LSM1B are essential for the formation of the cytoplasmic LSM1-LSM7 complex which regulates developmental gene expression by the decapping of specific development-related transcripts. Required for P-body formation during heat stress.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MPWSDADHTLFSSSLASYLDRKILILLRDGRKILGTFRSFDQYANIVLEGTSERVMVGNLYCDIPLGLYVIRRENVVLIGERESAEEELSPHMTCVSAAEIKRAQKAEKDAAELKGSMRKRMEFLDFD
The following text describes a protein:
Function:
Involved in the regulation of plant growth.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing VUP3 exhibit severe dwarfism.
Sequence:
MENSALSNCVRRTNFSNQQRTMQEGLEESSWTMYFETEDGLGHYDDSSMMSDAASPMGCVEEDTASSPSNRTEGYSGMEDNTIEEKTMNNGKIEEKILNKNGIKIEEYCAELKKRGLCLVPLSMLSNYIG