lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP100 plays an important role in several nuclear export and import pathways including poly(A)+ RNA and protein transport.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).
Sequence:
MFGNNRPMFGGSNLSFGSNTSSFGGQQSQQPNSLFGNSNNNNNSTSNNAQSGFGGFTSAAGSNSNSLFGNNNTQNNGAFGQSMGATQNSPFGSLNSSNASNGNTFGGSSSMGSFGGNTNNAFNNNSNSTNSPFGFNKPNTGGTLFGSQNNNSAGTSSLFGGQSTSTTGTFGNTGSSFGTGLNGNGSNIFGAGNNSQSNTTGSLFGNQQSSAFGTNNQQGSLFGQQSQNTNNAFGNQNQLGGSSFGSKPVGSGSLFGQSNNTLGNTTNNRNGLFGQMNSSNQGSSNSGLFGQNSMNSSTQGVFGQNNNQMQINGNNNNSLFGKANTFSNSASGGLFGQNNQQQGSGLFGQNSQTSGSSGLFGQNNQKQPNTFTQSNTGIGLFGQNNNQQQQSTGLFGAKPAGTTGSLFGGNSSTQPNSLFGTTNVPTSNTQSQQGNSLFGATKLTNMPFGGNPTANQSGSGNSLFGTKPASTTGSLFGNNTASTTVPSTNGLFGNNANNSTSTTNTGLFGAKPDSQSKPALGGGLFGNSNSNSSTIGQNKPVFGGTTQNTGLFGATGTNSSAVGSTGKLFGQNNNTLNVGTQNVPPVNNTTQNALLGTTAVPSLQQAPVTNEQLFSKISIPNSITNPVKATTSKVNADMKRNSSLTSAYRLAPKPLFAPSSNGDAKFQKWGKTLERSDRGSSTSNSITDPESSYLNSNDLLFDPDRRYLKHLVIKNNKNLNVINHNDDEASKVKLVTFTTESASKDDQASSSIAASKLTEKAHSPQTDLKDDHDESTPDPQSKSPNGSTSIPMIENEKISSKVPGLLSNDVTFFKNNYYISPSIETLGNKSLIELRKINNLVIGHRNYGKVEFLEPVDLLNTPLDTLCGDLVTFGPKSCSIYENCSIKPEKGEGINVRCRVTLYSCFPIDKETRKPIKNITHPLLKRSIAKLKENPVYKFESYDPVTGTYSYTIDHPVLT
The following text describes a protein:
Function:
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTEDKITGTLVLTVFTATLSSFQFGYDIGVINAPQEIIISHYAYVLGIPLDDRKAINNYTINSTKELPTTPCLMDSIPTPLAEEETTASSNLVTMLWSLSVSSFAIGGMIASFFGGWLGDRIGRVKAMLVANILSLAGALLMGFSKLGPSHILIISGRSLSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLAIVTGILISQIVGLNFILGNHEQWHILLGLSGVPAIIQSLLLLFCPESPRYLYIKLDEEVRAKKSLKRLRGDADITKDIAEMRKEKEEASSEQVVSIIQLFTNSCYRQPILVALMLHLAQQFSGINGIFYYSTSIFQTAGISEPVYATIGVGTINTIFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSLGLVLLNKLAWMSYVSMVAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRTAALAIAAFSNWACNFIIALCFQYIAKFCGPYVFFLFAGVILAFTLFTFFKVPETKGKSFEEIAAEFQKKRGLAQKPKAAVEMEFLGATETV
The following text describes a protein:
Function:
May play a role in the trafficking of a subset of G-protein coupled receptors.
Subcellular Localization:
Membrane.
Sequence:
MVKTINVDSSLSKYFNTIVETGKPTCGIIIGKTSKTKDYVVNLIKCPTKDAAFKLDDQWVASHAVNVSHMLPGGVTVIGVFVVADTKTVEATALRKVVYSVYRRLSQIKSSYGLKLTSEESLSYTALHVDVSSGRTLSCKQYDVLDNGSGTKPADWKYVNSPTRWSTLKTEVCFDKLFYVDSLTEVMKELKTSLSEFSCDVTNGIVCIDDVIRNNEDVLDPEPSSGKGKKSKNTNPSKWGKTFHCKLYLPLKGDEDINEVEASSHKCSVHLHGTITGLAYTTSKTTVEEAVHQLKCDIIQNLFHRYNLLKQNLEDHKTKLCPTMDIALPKRLLFTEGESENFLFSEFLFRNEPIAEGVDRIRETFSPDVKEDLIHSEAEKFPENLIQSIQAEPEIEETPEDLTEAFDQLEPTRTTDLPTQETTQPTYTTDDTTTTNEEENVEKSSSQTGSQSPKDEAEVSLLQSTKGFVAAGVAVVVAFLMSYLSLRD
The following text describes a protein:
Function:
[Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1. Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature. Contributes to the regulation of RPS6KB1 phosphorylation.
Domain:
The C-terminal half of the protein is important for interaction with RBX1.
Sequence:
MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIEEGHTDQLLEIIQNEKNKVIIKNMGWNLVGPVVRCLLCKDKEDSKRKVYFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQSILLLLQPLQTVIQKLHNKAYSIGLALSTLWNQLSLLPVPYSKEQIQMDDYGLCQCCKALIEFTKPFVEEVIDNKENSLENEKLKDELLKFCFKSLKCPLLTAQFFEQSEEGGNDPFRYFASEIIGFLSAIGHPFPKMIFNHGRKKRTWNYLEFEEEENKQLADSMASLAYLVFVQGIHIDQLPMVLSPLYLLQFNMGHIEVFLQRTEESVISKGLELLENSLLRIEDNSLLYQYLEIKSFLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQGKYTLFRCLLNTSNHSGVEAFIIQNIKNQIDMSLKRTRNNKWFTGPQLISLLDLVLFLPEGAETDLLQNSDRIMASLNLLRYLVIKDNENDNQTGLWTELGNIENNFLKPLHIGLNMSKAHYEAEIKNSQEAQKSKDLCSITVSGEEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKTKSTSEENIGIK
The following text describes a protein:
Function:
Binds, preferentially, to the Maundrell ARS consensus sequence within ARS3002.
Subcellular Localization:
Nucleus.
Sequence:
MNFYSLLPSRHDVSADNITEKFCQFCLCCNPWYAGADTRQLANAFNMIPKSEGQKFEIWVLFLLVRQYHQKIINSWSKLVGFLGVERKDEQSTQKIQQYVVRLKRWMSQTHVDAFFDYLLNKPNPYYLEIPETQPQVRCNVNVTDDLVIKSLRAGLMSHPDVNSSSISTMRTSTSPSNWIHSASASLDDNTHNLGSFVTNPHADSQECPTPQSLLMRASHHMSERGSQQAHQTTPQNHSLPHPPNMFEPPDEDHQLPSAANNSHNHDHAFQTAEAVGVADSIDPDWHQWPDDLRDVSSPKESDGLNDSWSRQTNQVETENVENEAGVPRKRGRPPGARNKIKRLRSEPSVSLTLSISWYERFEKLMHAQNTMLRSAFSHVARLPMETVSQLLSHYTETISQYLPPSETSPIPKTPNFKFISSTLLALVSSHSEILEASTDRLIWTVHQGPLTATICHAFNLEKAPSMHSLAEAQMIPDVPISHSNSMEPLDTVSSLKLEIAKLNAALKEKNLELENLKRKIMNAVFD
The following text describes a protein:
Function:
Proton-associated sucrose transporter. May be able to transport also glucose and fructose.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPRAGWLAGLLCPDPRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSVYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAALGPAEPAEGLSAPSLPPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVAELCSWMAFMTFTLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHREKQVFLPKYRGDTGGASSEDSLMTSFLPGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDVSVRVVVGEPTEARVVPGRGICLDLAILDSAFLLSQVAPSLFMGSIVQLSQSVTAYMVSAAGLGLVAIYFATQVVFDKSDLAKYSV
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAGGELTGRLYSLLFRRTSTFALTIAVGVLFFERAFDQGGDAIYEHLNQGVSCPWPHSPPPPANKNNGRIS
The following text describes a protein:
Function:
Represents a citryl-ACP lyase.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLRRSMLFVPGSNAAMLSNSFIYKPDSIMFDLEDAVALKEKDSARLLVAHALQHPLYKEIETVVRVNPLDSEFGLLDLNSVVRAGVDVVRMPKTESAQDVLDMDHAITEIEKACGREAGSTKMLAAIESPLGITQANQIAFASKRLIGIALGAEDYVRNLKTERSPEGIELLFARCSILQAARAAGIQAFDTVYSNANNEEGFLKEAALIKQLGFDGKSLINPRQIELLHNLFAPTQKDVEQAKRIIEAAVEAERQGAGVVSLNGKMIDAPIIDRAKLVLERAKSGIREE
The following text describes a protein:
Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Subcellular Localization:
Secreted.
Sequence:
MSHLLPLLLLLLVPAGGCWREEPQKLCAHRFIRALVQVCGGPRWSPPEGRQDSARDDRLLSRETRRASVWREERSPTIRNQQEILQWLQNRAFRGLAPDGSMDENLDEGLAVGAGEPESPSGIRRAPRWRRANSSPAQHCCINGCTKQDLLAFCPH
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle.
Sequence:
MATKDAFEGLDVTADEVQRIEKALKNEEFRKLFVEYAQEISDPENKKKYEEELAELERSRGMDVKFLHPKPGYVLKTSIDGEKKAFINICKNESIGKPQATNSAQGSGNARKMGVEWSLPHSLAPGRDDYDHAGKKCVVYDCMFHPECFEMITKDSRFRTLMNSSAIDGIEREFKVKLDRNNVKKPKMTFKGRPQATVLRTPSQAGPTGENSLDALNLSYPYDQSTKPETLNQPAKTPSKISGNRDSERKTNDEKKLEKKDGFTEPKYSIVHRGHFDLQQFTYARDSAPSTRPQELILKVEXPLLKSAATVQLDVFEKRIFLECKKPVFYRLDLPLPYPVDEDKGSAKFDKGRACLIITLAVLPPTKENDAISPDCNDDEESTVGCEKSDTSANQQEDSDEVKPGDGDLGSSSDHEIASSVGADPTSVLGNIQEQKVTLIIREANVDEESFKLDTVNGGKMVEAMFKRTKMASDTAEEMFTLLVSCEEGQTLDAKVNTDVSKLNVVLVFKKMEGSGCLWSALKAGVSADALEEKRFATEESLEDALEEITSDEGRSKETMPCSVSEFSTDCVKAQFQVTCEVADNGKSSQASAKHKGESDGSKKASVRSKESIIPALDLGPAADETKEESDVSSRHSDSHLKSALRSPRRRACKSVSFSEEVLVELFLDGPKKPKKGYNKKKGGRRTPFFGPRRMIEKLKDNSWEYFSDSELLHHKDGSTEEYEDLEWKWQPDQVLMRQSSSESESGQEIPSSPRTNGKKSKGSRRRRKEKARREASSAASNGVESSDTNENHIKPSSPGDISPLTNGVESDAKKQSSKLNGEAQDLPENSDSKNNNDEIKKSNENDELPLEMQDHKTKCAFEFSNQVIFDLDE
The following text describes a protein:
Function:
Serine hydrolase involved in the detoxification of formaldehyde.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLTLGSVVRNASRILGSRVSASSYTFLCRRGSTIVTRAASEGNQVDNMATPQEMSSNKVFGGFNRRYKHESSSVGCPMTFTIFFPPAADSSKVPVLYWLSGLTCNDENFIQKSGAQRAAAAHGLALVAMDTSPRGLNVEGESDSWDFGTGASFYLNATQEKWKNWRMYDYVTKELPSLLSSHFPQLDTSNASLFGHSMGGHGALTLFLKNPSKYKSVSAFAPICNPTACPWGVKAFNGYLGAEKSAWEEYDATLLVTKYNGPKTTILIDQGDADKFYKENQLLPENFEQACKSAGMPIDMRIQPGYDHSYFFIASFVEDHIQHHAKALSV
The following text describes a protein:
Function:
Negatively regulates chemotaxis and olfactory plasticity which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. May be down-regulated in response to pheromone exposure, resulting in promotion of olfactory plasticity.
Subcellular Localization:
Secreted. Perikaryon. Note=May be transported to neurites in an unc-104-dependent manner and secreted from there.
Sequence:
MARFTPLLMILLALVPLYYSLDCRKFSFAPACRGIMLKRSGGHPMIAEQQPMIDNAKAREVQMMELLIRNIEDEALIANSDCVSMSWLRDRLVNAKNEMPQ
The following text describes a protein:
Function:
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides.
Subcellular Localization:
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Domain:
The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.
Sequence:
MAALWLLLLVLSLHCMGAGGFVAHVESTCVLDDAGTPQDFTYCVSFNKDLLACWDPIVGKIVPCEFGVLYPLAENFSRILNKEESLLQRLQNGLPDCASHTQPFWNALTHRTRPPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLSGSTYPEGRH
The following text describes a protein:
Function:
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Note=Associates with the endolysosome membrane.
Sequence:
MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDDCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPTEDAQEDAEKAKGTEGGSKGIKTSGESEEIEMVIMERSKLSELAASTSVQEQNTTDEEKSAAATCSESTQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAAEKTTYNHPLAERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLVRHFYKGEDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVPGFAVAQCINQHSSPSLSSQSPPSASGSPSGSGSTSHCDSGGTSSSSTPSTAQSPADAPMSPELPKPHLPDQLVIVNETEADSKPSKNVARSAAVETASLSPSLVPARQPTISLLCEDTADTLSVESLTLVPPVDPHSLRSLTGMPPLSTPAAACTEPVGEEAACAEPVGTAED
The following text describes a protein:
Function:
Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit pol1, an accessory subunit spb70/pol12 and two primase subunits, the catalytic subunit spp1/pri1 and the regulatory subunit spp2/pri2) is recruited to DNA at the replicative forks. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MRKRNAGIKPSQRFAELRALRQAGKTRASTYESKENEELYDNVSEEEYRKIVRQRLDEDDFVVDDNGAGYVDNGYDEWDQSHYSDEDDENEKGSSGRKRKKSKNVLAEPNQQIGAFFKANAIQPASRIANRKNNEKEDEFMAEILGSIDQDIPERLSTKKGNRSHTTSNAKRRSQKAASSISTTNVVSSDPKKYIPETVPSTPQPASSLPIPSSPPAALETEENVDSQPMELDEPELPVGSDAPIIDVEESIAMKPLMSHDQVDDTASLSKATISQQPLSPMTPLSSELDVSAFSEINSKIKNVDVPASSYSSPISKVSPSDVTEEDGSLFFFWMDYTEMYGSLCLFGKVYDKATKQYVSCFLKVDGIMRSLYFLPRPSSSSVSEDSIAAQTKDVYDEVANLLSKRGVKEWKSRVSKYKYAFELEDVPRTADYLEVIYSYSYPALPTDLTGSSFSHVFGTNTALFEQFVLSRRVMGPCWLKIQQPNFDAVKNASWCRVEIGCSSPQNISVSFEKNEITSKTPPMTVMSLAFRTLINKEQNKQEVVMISARIFENVDIEKGLPANDMPSYSFSLIRPLKQIFPNGFEKLARQHKSSIFCERSEVSLLNNFLNKVRTYDPDVYFGHDFEMCYSVLLSRLKERKIHNWSSIGRLRRSEWPRSFNRSSQQFVEKQIIAGRLMCDLSNDFGRSMIKAQSWSLSEIVLKELDIKRQDINQEKALQSWTDTAHGLLDYLVHCEIDTFFIAAVAFKIQMLQLSKNLTNIAGNSWARTLTGTRAERNEYILLHEFKKNGYIVPDKQQSIRRHAEAFGAEDGLQEESLGKKKDKYKGGLVFEPQKGLYETCILVMDFNSLYPSIIQEYNICFTTVDRSPSNSDSDDQIPDTPSASANQGIFPRLIANLVERRRQIKGLLKDNSATPTQRLQWDIQQQALKLTANSMYGCLGYTKSRFYARPLAVLITYKGREALMNTKELADQMGLQVIYGDTDSVMLNTNVTDKNHALRIGNEFKEKVNERYSKLEIDIDNVYQRMLLHAKKKYAALQLDSQGKPNLDVKGLDMKRREFCTLAKEASKFCLDQILSGELTETVIENIHSYLMDFSEKMRNGKFPANKFIIFNRLGKNPEDYPNGKTMPFVQVALKKKARGENVRVGDVIPFIIAGSDADGHPADRAYSPQEIMNTNSTLVIDYNYYLSHQILPPIERVIAPIEGTNRARLAECLGLDARKYYSHETSESSAFQRYESTLTDDQCFINVSPLLLKCPSCNATSFSLRSVKSLKETLYANTVECDCGYEYSDFTIILQFSSQLRDFINLYYEGILVCDDSSCGNRTRQMSVYGKRCCNKSCRGSVHFEYNDEQLYNQIKFLLKAVQTTTGATRNGIIRCNAINKNISRIMNKNAREFVDMGLIFSS
The following text describes a protein:
Function:
Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs. MKK4 and MKK5 participate in the regulation of floral organ abscission. Mediates osmotic-stress response via its regulation of MPK3 activity. Target of the Pseudomonas syringae type III effector HopF2.
Subcellular Localization:
Cytoplasm. Nucleus. Plastid, chloroplast stroma.
Sequence:
MRPIQSPPGVSVPVKSRPRRRPDLTLPLPQRDVSLAVPLPLPPTSGGSGGSSGSAPSSGGSASSTNTNSSIEAKNYSDLVRGNRIGSGAGGTVYKVIHRPSSRLYALKVIYGNHEETVRRQICREIEILRDVNHPNVVKCHEMFDQNGEIQVLLEFMDKGSLEGAHVWKEQQLADLSRQILSGLAYLHSRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGKYDGYAGDIWSLGVSILEFYLGRFPFPVSRQGDWASLMCAICMSQPPEAPATASPEFRHFISCCLQREPGKRRSAMQLLQHPFILRASPSQNRSPQNLHQLLPPPRPLSSSSSPTT
The following text describes a protein:
Function:
May activate the lysosomal degradation of sphingolipids.
Subcellular Localization:
Secreted.
Sequence:
MLLALLPLLGFLGATLTSPVSVPQECAKGPAVWCQDLQAATRCGAVGHCQSAIWSKPTAKTLPCDVCLDVAAASSHGLNPDATETDILALMIKTCEWLPSQASSAQCKGMVDAHHSIILSMLGGAPAQLCAALTLCQPLPRHPASPGPLSEEDISEVVAPFMANGPLSFHPPQIPGDAVCQDCVQLVTQLQVAVGSNLSHLAETITQEQCESLGPGLALLCKNYIRQFFAPTEQTLRLAPPKEICRKRGFCEELREPALLAHTAAGHDDIPSLEPVSPRKKSEIQMKSGLTCEVCLEVVQELDQWLESNSTETVIRHTLERVCSKMPAPIVQQCVILVDTYSPSLVQLVASVAPEKVCKAIRLCRSQRRARAVHEDLATVPSPVLGQENRVSFCNGCKRLFGVSARNLERKSTKRNILMAFQGGCSILPLTYMIQCKRFVTEYEPVLVESLMEMMDPEALCMKMGACHAPRTPLLGTDQCIMGPNFWCKSWEAAELCGAVEHCQRHMWKVTPFRAGEHA
The following text describes a protein:
Function:
Transcription factor that seems to regulate organogenesis in postembryonic development. Involved in the regulation of shoot branching by controlling axillary meristem initiation. Functions in association with LAX2 to regulate the process of AM formation. Possesses transactivation activity in yeast.
Subcellular Localization:
Nucleus.
Sequence:
MHDPRGFPIHPQPYHLHPTAGGLGEGRMRGGGRRRPGAKLSTDPQSVAARERRHRISDRFRVLRSLVPGGSKMDTVSMLEQAIHYVKFLKAQVTLHQAALVQHEEGCQHADVAAAFSAADADLALELNHRHGGAGDDDAGMTTLEMAPMQEAVGYGDGPAHQMMQQALDPAGQLMMGGAHQLPPLPCCVFVQETDPSCYSVCNVHGEESGAQGSY
The following text describes a protein:
Function:
Acts as an osmosensitive calcium-permeable cation channel (By similarity). Required for spore wall assembly and ascus formation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNATKELTFNLLNKFQDKERFGSAQRHAGISLKGFISGILFSFLYFLFQLSLFIILRSRFKTIYQANVVLKIHPGSKVCFAKKKIKNYWSLFAFLKQLPGRMLDPMEKFERNERYGLDNYLFLRFLKLLIFFFAVLSIINIPILIPIHYFSRDILKENEGERYEQSFRTTSKLDKWTMSNLSPNSSNTLICHLFLSIFVVLWFHFILSSELRFVNRLGYSVLTKSKYQNILYLEGFSSKLVTQSISLETFFQPLHSDCFGVTHFIPKNLKKVHKLEIKLNKLQKSKEQIIFEIILEKYFRRVSIHRHLIANHKRFFFSKLKNHLLFQYKKLVFLTQFRISYYCTKIRLRWKKSSIFPLYYPKLYVNTETILERKYRILDKIIRKEKLIKFQVNSLKATSETKQALPDDLSSGTDIYMDKMFITFKSTLLSNVIGELLSYRLPTQNLKVIIGPNVNDIIWRNILDSSPLWKSAKYFSANILRIFVIIGWILPVAFLGLISQIPNISSLIPFTKIIHFQSPFIREVAKNLIPIVTLIIIIEIVPYFFRWLSYLRGLKTGAQIEADVQNWYFVFVFIHLFVVVTISSGFSIIIERLLNNPVSIPALLANDLPKCANFFCSFVLIRGMAYAGGNLLRIKELLFELFYYKWKRSTPHAQFKRLKTSLFFQLGSIYPIFSVLGCIGIIYSVVAPIILLLCCISFSMVFFSFSYLFKYQYNKENYSETFGKLYIQALMQLYAGIYFMEFCLLGLFTLFDQYTLSTIMLVVFALTVITHSKISKQIKSKPQRIPTLEYLSNLTEERKDQFCQESYTFHDIFSICRNSDEIWLPRDKLGISEEEQSFLEKSYHLKFDLNMYSMNLFGDCHLENSHLH
The following text describes a protein:
Function:
Component of the high-osmolarity glycerol (HOG) pathway involved in mating response and osmotolerance. May act as a membrane anchor for the STE50/STE11 complex.
Miscellaneous:
MISCELLANEOUS: Present with 1160 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Vacuole membrane; Single-pass membrane protein.
Sequence:
MSSSSKASASSSLSSTATSSTSATRGSDGCVVCDSTASCPVCASGEYCVMTSLTCDKCPSTYCAKQSDSQLSSLSSSSSSSSSSNSNEKTSLIVGFTVGIVGGAMLIALVALYFINKRYWKPKRQKNKALKLEEASQSYGNEEEYFDDEDDDDEDDEDDGGMRKDESHTLFNTSLVPPTLNVPGNRSSASTTRTRASNILPIAYIPGVTSGLSTDKLQSKLRSSSKRQNAAGDIRSHITLGSSILDGLDDEDDEHNQVLNKDADDNLITAIRAKPKLVQIAEEESDKEIQDLDVIEEQTEADDLSHMAKSEASHGNNDEDDDEEGSFILDLEIPESIRESTQGSRTESPFEDKFEIHDER
The following text describes a protein:
Function:
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MASAQSVLTFAVCILLISEIILAKKTYYDILGVPKNASERQIKKAFHKLAMKYHPDKNKSPDAETKFREIAEAYETLSDESKRKEYDQFGHDAFANGGGGGSDQHFHKHFNFNFDDLFKDFDIFGESQNSRSKRHFQNHFRSHQEAHNRHRQHFEDFSFGGGLFNDMFEDMEKMFTFGGFDGTRRNPMRAESGFQGSSKHCRTVTQRRGNMVTTYTDCSGQ
The following text describes a protein:
Function:
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle. Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYIRSQSFRTLRNSLTNLKLPVSESSLSEEHSLWIPQIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQHVFYFDEIFDEACTNQDIYMKTTHPLIQHIFNGGNATCFSYGQTGAGKTYTMIGTHQNPGLYALAARDIFRQLEVSQPRRHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIVGLRELQVDSVELLLEKSPYGFYFQVILKGSKERSTRATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQQVVIQAHQEQLDEMAELGFKEETLMSQLAPTDFEGFVIQLDEIMVLKSKCIQSLRSQLQLYLACHKPAAGPKRTAVS