lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. PatF catalyzes the conversion of phyllostine into neopatulin. The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MKSSLWVSLAVSLIGLGPAAARNDYPGNYPSSSPPLGPTDWERTPVSVFAKVLNTQPDPDYNLLKELVTYDCTYISLTFDNPTLHGIMPWAGTHTHVGPQAFIDIFTRVGLYWDRGPFSIDHIFGDDGNVTAWGSFTATSRTLGKTVISPWAARARVNSANQIFEFQWMEDTFTTASSFGSDNSTKVFIANPEGGTAHA
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVEAYVHDNNTHVDCRAPHHSGKSVSLERLASLGVFYRHCRSQDEVDAVACARHYSNRDEVTISPASFPSEDAFRDKLAVFYTEHLHEDEEIRYALAGEGYFDLRDATTGDWIRVKLTTGDLLIVPAGIYHRFTVTESNFIRAQRLFKDEPKWQAFNRPEGDARPVHKEYLASLAI
The following text describes a protein:
Function:
Involved in transporting aromatic amino acids across the cytoplasmic membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKPKDFIMSKQPSLFGGACIIASVCVGAGMLGLPSAGAGAWTLWSMLALALTMAVMTLSGWMLLEAFKHYDLRVSFNTVTKDMLGSHINRFNNLTVYFVGGILLYAYITSSGLILQDLLHINSKIASILFVAVFSAFVWHSTRAVDRISVILIVFMVLSFIFGVSGLAINVKTSILFDTLNQSGEYAPYAMAMLPVALTSFGYHHSVSSMRAYYGEERKAKYAILGGTVIALSLYALWLFSIFGNLPRADFAPVIQQGGNVDVLLKALGSVVESEKVSQAINAFSMAAILSSFIGVGLGVFDFLADLFQFSNCKQGRTKTWLVTFLPPLILSLLFPFGFIIAIGYAGAAATIWACIIPVLLARKSRTLANGAQGFVVPGGNLALGLVLIFGVLTAVFHMMAMANLLPAFKG
The following text describes a protein:
Function:
5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR). Promotes HR by directly stimulating RAD51-mediated strand exchange activity. Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment. Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks. Required for recruitment of replication protein RPA2 to DNA damage sites. Promotes the initiation of the G2/M checkpoint but not its maintenance. Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps.
Subcellular Localization:
Nucleus.
Sequence:
MESQEFIVLYTHQKMKKSKVWQDGILKITHLGNKAILYDDKGACLESLFLKCLEVKPGDDLESDRYLITVEEVKVAGAIGIVKQNVNKEAPELNSRTFISSGRSLGCQPSGLKRKFTGFQGPRQVPKKMVIMESGESAASHEAKKTGPTIFSPFCSMPPLFPTVGKKDVNNILADPENIVTYKNRERNAMDFSSVFSPSFQINPEVLCEENYFCSPVNSGNKLSDSLLTNEPVKRDSLASHYSGVSQNIRSKAQILALLKSESSSSCEELNSEMTEHFPQKQPQGSLKIATKPKYLIQQEECAEMKSTENLYYQHQSENTMRNKSRWAMYLSSQSSPIHSSTVDGNDTERKPKAQEDDVNSNLKDLSLQKIIQFVETYAEERKKYNVDQSVGNNDPSWNQEVKLEIPSFNESSSLQVTCSSAENDGILSESDIQEDNKIPFNQNDKGCIKGSVLIKENAQEVNTCGTLEKEYEQSESSLPELKHLQIESSNNSRISDDITDMISESKMDNESLNSIHESLSNVTQPFLEVTFNLNNFETSDTEEESQESNKISQDSESWVKDILVNDGNSCFQKRSENTNCEEIEGEHLPFLTSVSDKPTVTFPVKETLPSQFCDKTYVGFDMGICKTENTGKEIEEYSDTLSNFESFKWTDAVYGDNKEDANKPIQEVRINYDFALPPNKSKGINMNLHIPHIQNQIAENSNLFSEDAQPQPFILGSDLDKNDEHVLPSTSSSDNSVQLLNTNQNHYECIALDKSNTHISNSLFYPLGKKHLISKDTEAHISEPEDLGKIRSPPPDHVEVETAREGKQYWNPRNSSELSGLVNTISILKSLCEHSTALDSLEILKKKNTVFQQGTQQTYEPDSPPEVRKPFITVVSPKSPHLHKDSQQILKEDEVELSEPLQSVQFSSSGSKEETAFQAVIPKQIERKTCDPKPVEFQGHQVKGSATSGVMVRGHSSQLGCSQFPDSTEYENFMTETPELPSTCMQIDFLQVTSPEENISTLSPVSTFSLNSRDEDFMVEFSETSLKARTLPDDLHFLNLEGMKKSRSLENENLQRLSLLSRTQVPLITLPRTDGPPDLDSHSYMINSNTYESSGSPMLNLCEKSAVLSFSIEPEDQNETFFSEESREVNPGDVSLNNISTQSKWLKYQNTSQCNVATPNRVDKRITDGFFAEAVSGMHFRDTSERQSDAVNESSLDSVHLQMIKGMLYQQRQDFSSQDSVSRKKVLSLNLKQTSKTEEIKNVLGGSTCYNYSVKDLQEISGSELCFPSGQKIKSAYLPQRQIHIPAVFQSPAHYKQTFTSCLIEHLNILLFGLAQNLQKALSKVDISFYTSLKGEKLKNAENNVPSCHHSQPAKLVMVKKEGPNKGRLFYTCDGPKADRCKFFKWLEDVTPGYSTQEGARPGMVLSDIKSIGLYLRSQKIPLYEECQLLVRKGFDFQRKQYGKLKKFTTVNPEFYNEPKTKLYLKLSRKERSSAYSKNDLWVVSKTLDFELDTFIACSAFFGPSSINEIEILPLKGYFPSNWPTNMVVHALLVCNASTELTTLKNIQDYFNPATLPLTQYLLTTSSPTIVSNKRVSKRKFIPPAFTNVSTKFELLSLGATLKLASELIQVHKLNKDQATALIQIAQMMASHESIEEVKELQTHTFPITIIHGVFGAGKSYLLAVVILFFVQLFEKSEAPTIGNARPWKLLISSSTNVAVDRVLLGLLSLGFENFIRVGSVRKIAKPILPYSLHAGSENESEQLKELHALMKEDLTPTERVYVRKSIEQHKLGTNRTLLKQVRVVGVTCAACPFPCMNDLKFPVVVLDECSQITEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMGHKPILLRTQYRCHPAISAIANDLFYKGALMNGVTEIERSPLLEWLPTLCFYNVKGLEQIERDNSFHNVAEATFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAVDFHHPDIKTVQVSTVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGKRHLLIVGNLACLRKNQLWGRVIQHCEGREDGLQHANQYEPQLNHLLKDYFEKQVEEKQKKKSEKEKSKDKSHS
The following text describes a protein:
Function:
Gamma-glutamyl cyclotransferase-like protein; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp. The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain. The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin. This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties. Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure. GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides. Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA. Gliotoxin contributes to pathogenesis during invasive aspergillosis. In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGKAALQDPHGGIWYFAYGSNLRLSVLENRGIKALDIKAVIVPSHYLTFDIFGIPYAEPSFASVAPFAREKKTTLRLGDSPASRDVPPVQGLAYLLNPRDYRQLVISEGGGVAYDEVEVHASILDKDGKPDPGATLIARTLQAKYPWRPNGAPSARYLGLISTGCKQNEPLTAYSDYIDSLPAYEPPTSLHAKVGGLLFLMFWRPPLRLLIRLIRVNTDQDGHCPQWLGWIILTLYGLMWSYHDNIHSKIWGRGDGRKLHFEETPAKEVPVRH
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MSSGIGAWGGSGTCYPIFSDFCTCIFDKPLELCEPYRKDYLECLHNVKEYKSQSSENYHKGGEERINKVREAIKRAQEYDPKKGKSE
The following text describes a protein:
Function:
Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MSSPSDLPLETVARSPSIEEEDEDDEELEETLSERLWGLTEMFPESLRTAAGASMDLSICAAKKFYSFSRTALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPSTGMSGPLPPLPGKA
The following text describes a protein:
Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Subcellular Localization:
Chromosome. Nucleus. Chromosome, centromere.
Sequence:
MKAKKIRRQSENQSRKSSGRRSRDSGIINGDRAEAVTLFEVICIGKGAIQSVVSDWVEVYQEDRDAALLDLLNFYIQCSGCQGVVTAEMFQNQGDQDIVQRLTEEFDEETGLQFKKFMAFPWILTITWPNNMENGDYPLSKAGTFWKKFRANICELTSVLVQKCQYNAIYDGYLLDTVISLLLGLSDSCIRAFRHTSTLSALKLHTALVRIILNLETSIHNLQRLYNVEQKRFTLKKASYRMEQIEKKRNEIEQKHVEITNMIDAIFKGTIVQRYRDVVPDIRALCIEELGIWMKMYPQVYLNDSCLKYIGWMLYDKVPDVRMKSLLSLQGLYERKDFVAKMDLFNTRFKDRIISMTLDRDHDVSLQAMKLLMFMSQNCEDLLTKEDCDYVYQCVYTAYRPLATAAGEFLYKRHLNQKEGEESRGTIHNAQAQQLKILLTFFSENKLHEHLTYLVDSLWDCNSRLLKDWQCMSSVLLQATQDREDALNAIQQRLLIELLLASVRQAVEVHPPVGRGTVRKWVINRGDIARPTTATGSFKMLSAKEKKVQLEDHIKITEHFAQTLPLLLAKYLTDQRNVANLLQILQYFKFEVYSTKGLDKELEALLNELKHVALTHSDPEVLEACSKAYISLGKEDLEHHVSVGLAKREMIEQLVDTFSQMLHDLLQEEEEPLSSEGVHQMSCVLRKLAAFHNAHDPTEWNLYEKTSQLLQYDVENCCFSVQLLVPAFQCMYYALLWNVVAVMEDILSKEDPVLFREHVATFWQLCKHYLNHIDGSVQEQAFMSMCDILLLLSQHRNGIYCCMDSALQSELFSFVQHHVFQSDDVKHKGVNGKEKDKTVNSEGLHKRRNLLAAYCKLIANNIVEMAAASEIYKQYMKTYNDFGDIIKETLSRTRQTDKIESTRTLILCLEQLFQKHREAFGSATLTSPSFFNIKEMARRFSLTFGMDQAKCRESVVMIHKQGIEFVFREPALEDNLPPPNLPFLIPISEFSGKLLKADKRLVYGYLQRFANERMLLCEGTEWNPLVVYSHSLLDNVDEESSFTSSNYSRDLKTSSPTKRKPIAVRRVIPEEPKMYYPVQRRKRHLLHGENVDDEISLCSSLSHSLQRSVKRLSSHGDADEGKEDVEVDEVLVSKEIILHTESESQDSTG
The following text describes a protein:
Function:
Required for full activity of the EbgA enzyme. Exact function not known.
Sequence:
MRIIDNLEQFRQIYASGKKWQRCVEAIENIDNIQPGVAHSIGDSLTYRVETDSATDALFTGHRRYFEVHYYLQGQQKIEYAPKETLQVVEYYRDETDREYLKGCGETVEVHEGQIVICDIHEAYRFICNNAVKKVVLKVTIEDGYFHNK
The following text describes a protein:
Function:
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress (By similarity).
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MTQTAAPGRVQTLTKEQEKVLKQVWVHLFQFWGIDVDGSAVLTAKEPEPAAPSGKGRKLLGLFGKRKDATGAARKESNGKAAAKVYDAEKVEDSDAEKEKPTPQKVEGLEEMYELLKELDGAAVSKEFWSMLRCDYPDNLLLRFVRARKWDINKAMIMMAHSLRWRLNEGKPEDIVFGGERGAQKADKKGIVKQLELGKATVRGFDKNGCPIVYVRPRLHHAADQTEAETSEYSLLIIEQARLFLKEPCDTATILFDLSGFSMANMDYAPVKFLITCFEAHYPECLGKLFIHKAPWIFPPIWNIIKNWLDPVVAAKIAFTKTAADLEEFIPAEQIPLELGGKDEYNFDGFVMPDGSADTKLSDEKGKAAVLEEREAIIKRFIDATISWIESTSDEESAKWLEKKIDLSKELSENYSKLDPYIRSRSFYDVNGTLKV
The following text describes a protein:
Function:
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKMLKVFGAVLALFSILTIIWSIAFYVATSLLNAFDVNVSPFVAFLISDMVGFVFIILIWTLIGILMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNTMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVSYRLDQQLKQIVLNSEPLWAEKEIELELDLEKVYVIADQESMSQVWINLIHNSIKFTPSGGTITIQLKEHETVVEVRIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLHHGEIKVESEEGKGTEFIVRMPNHEEK
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MATQEKPPVVQELLQANEKYKNSFTNGDLPLPPAKKVAVLACMDARLDPARALGLEEGDAHVIRNAGGRAKDALRSLIISQILLGTKHVVILHHTDCGMRTFSNADIQAKIKERDGHESDIPDFLPYPDDEWGVREDIQLIRDSPHVPKDVTVHGVQRMHALQPAPPMSDRDTGGPSVQIACKRVAFVVKFSKTSPWDFRNCCNGY
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Arg-3' (H4R3me) of histone H4 with a specific activity for H4R3me2. Involved in the positive regulation of gene expression. Together with JMJ20, positively regulates seed germination by promoting the removal of repressive histone arginine methylations (e.g. H4R3me2) at GA3ox1 and GA3ox2 to trigger gibberellic acid (GA) biosynthesis.
Subcellular Localization:
Nucleus.
Sequence:
MPKCKNLLLTSKRRKSKSKRLKLHQHEPESLFPEKEVEEEDEDEGGFKLKIAAPSQEHGVQPLGNLYFNPGAVNVRNTGLGNLQILSDELVLDILGLLGANHLGVLATVTKSFYIFANHEPLWRNLVLEELKGDFLFNGSWRSTYVAAYHPKFKFAGDGESNLKIIDFYSDYLFQSWLCANLEMKPKWLRRDNITRVRGISVEDFITKFEEPNKPVLLEGCLDGWPAIEKWSRDYLTKVVGDVEFAVGPVEMKLEKYFRYSDGAREERPLYLFDPKFAEKVPVLDSEYDVPVYFREDLFGVLGNERPDYRWIIIGPAGSGSSFHIDPNSTSAWNAVITGSKKWVLFPPDVVPPGVHPSPDGAEVACPVSIIEWFMNFYDDTKDWEKKPIECICKAGEVMFVPNGWWHLVINLEESIAITQNYASRSNLLNVLEFLKKPNAKELVSGTTDRENLHDKFKKAIEEAYPGTIQELEKKAEEAKRAEEQRVSFWDSAKTDTFKFSF
The following text describes a protein:
Function:
Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin-dependent protein kinase unc-43/CAMKII in vitro. Involved in the regulation of sex determination. Together with fem-3, required for male sexual development by promoting the proteasomal-mediated degradation of tra-1, a transcription repressor of male-specific genes. Promotes apoptosis.
Sequence:
MEKVNEERDAVFEDHIGDRRRSVRSLLEEAFADEMEKTSYDVEVADTPQPHIPIRFRHPPIAGPVHDVFGDAIHDIFQKMMKRGQAVDFCHWVSHLIATEIDEKFSEVAFRDVQYNPDIYVTDSTTEAKKLFNDKIWPAIDKILQQNAETCPILSEKWSGIHVSGDQLKGQRHKQEDRFLAYPNGQYMDRGEDPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRDPSDSLEDQLRKSLELLDERMTVRSVKECWKGGSTAVCCAIDMDQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQLFVIGGELRVNGVLNLTRALGDVPGRPMISNEPETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYPVEDYAELSRFICTKAIEAGSADNVSVVIGFLRPPQDVWKLMKHESDDEDSDVTDEE
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.
Sequence:
MNPIMQNFIIESRDLIESAARGLLALEANPDDKAIINELFREIHTVKGASGILDNIAPFTQLAHRMEDLMQKVRDGHVALNGTMLDLMLGCCDQFLLWIEELEQHQELSAEAVSISKQMIAQLAPLTQAAPTHTPTPAVAAQEETATLSISELTELLGRDCFNDVEALLEHPDALLLIYTPDKQCFFSGDDPLAWMRSVEKVSWRKVVLIPDSEPFDTYQAQMQFLLLTQSAKKDLEQQLAPIEGQYRLYRIQSDNLPTAPIDQRTQYVERIVKQQIALLREEQVSESVRAGTFLSIKNLYCALSQQISDRPAPLPESVSADELITLFDNILLSFAHRTAIIDKCENEPAQPSAITVNEQLDKVKKKQIKTLKVDQEKVDLLMDLVGELIVAKNSMQYLAYRAENEFGVRKLAQDIKAEQSVISRLAEDLQSVVMQVRMVPLATVFQRYPRLIRDISRKLGKQVDLIIEGEDTEADKSIVEDLSEPLVHLIRNALDHGIESPDIRREQGKNPTGKITLSAFTLDDSVIIKMSDDGKGVDVERVKTKALERGLVEASKLERMSQQEIIHLIFEPGFSTVEQVSDLSGRGVGMDAVRTAIERNGGTLTLSSEPGKGSEITMILPLSMTISRVMMFELEQQSFAIPIESVIQTLKISRHKDIRRVKNLDTFILRGETVPILYLKRAFEMNSAQIYPDIQPILVVRVGDDVLGLAVDRLQEGQDVIIKPLEGALATFSIYRGAAIMGDGRVLLVLDTEEVVKHAR
The following text describes a protein:
Function:
Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MEDDDDFDPNAEKTMFNIKYSSIKDIRELNNGQMLSLRIMHSPDLISMQGIEQFRQLKQLNLSQNSIQAMSLRTLNQLEVLNLQSNRIKVINCEGLRSLRVLNLSYNLISLLGPLQIFTQQGYQLKSLDLRSNSISDLNELKYLQGTNLQDVFFNSDRRKNPICENLNQYYKQIIKYVPQIVNVDNKPRNELQENDGDGSNNITFKLPKQQQANIEKEAEMRVEVIQLQQKVKELSQQNKEIIYKFECNDKYWSSKCSNLEREIIDLNKFNQELNQENKRFRREIESLNEQNEYDKQQQKDLINKKERKDELITQLQNKISELLQLNGQLSKENQILIEQQNVQKVKDQEKEFKLSEYKIQLKEAEKQLQEFHKNAVEQASQTLMRQEQLQSKSEQINQENRSLYQDNSQLKRRIQELLEICREWEVKFETSQKENEQQFQIQLQQITHEYEQKLQVQQSQHEQQLQEFETESKLMQDQLENEFRNLFQENMEKFKQLKLQYDEKCRIEVQQSQEIKILQGRLLEQENLIKELQSALIRLKREVQEFCQEKDLAKREHQIIQSGLQRDINILQEQLLECQTRLQQYDRELRLKNDELQTINQENDRLRAQNKQKIQNEQLVDELQTNLTIKNKMLDDKNDTIDELKQQLNQLRNQEGNASDDYLKLQKKYDRQSQIIDELESQLQQIQEEYDQKNKDLKDKKQLISMFEKEIEEIEIKQDREINGLKLELQEKEGQLQELVKMLNNAKEELIKKDEKIRELLVQYQAIEKQLFVIDKQNEITVKQKDKQIVEMRSQLQQIQEELNLMIQENIQLKTKARENLQNLHKLFQQ
The following text describes a protein:
Function:
Folic acid-binding protein involved in salicylic acid- (SA-) induced folate accumulation by triggering uptake and accumulation of folic acid in cells. May be implicated in the transport of the folates from the site of production (leaves) to the site of storage (fruits and seeds) and utilization (roots) (Probable).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGRCLTKKVFLIQSPILFLHLLISLSSGAVKPDLKGVCVSKGGRFPPYELEGKPPKSVGRGSKDLTLCRVFRKKTCCSSVQTNPAFVAVRNLATYGEASQECLELFELLECSICNPNVGIQPGPPRICASFCDRVFEACKDAYFASNALKRVIGPCGVNDDIICIKASNWESNGTSFCEAAGFAVQRNDDSREKPCYGSKASLESVVESWSRDSRKETPLKTETLSCFKDLLQWVREMTTIQKISLGMSFLIAGMFLIRQSNNRNQKQRLAAIQRTARRLRGNGNGDSYSAAINRRTSSD
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPPVLRPENALKRADELISVGEPQAALQSLLDYITSRRIRFADPAAIEPIVFKFLELGVELKRGKVIKDGLYQYRKHVQSSTEGLKSVGAVSRRFIDLIEKKMSSEQAKANAEESTEEDLEGGVTPENLLISVYEQDQSVGGFNDEAVTSWLRFTWESYRTVLDLLRNNSQLEITYSGVVNRAMQFCLKYNRKNEFKRLADMLRQHLDAANYQQQKSKQYTVDLSDPDTLQRYLDQRILQVNVSVKLGLWHEAFRSIEDVHHLLSMSTRDPKPSVLANYYQNMAKVFFVSSNYLLNSVALQKFYDLYQQNPKATDEDFKFYASQLVLSALSIQQDDLPVVGYDPLARLAGFLNLESKPTRSQVIEAVSDSKIFSRADEPVKKLYELLNSDFDVNTLKESLASLLPELNSKSYFTQYVEPLKSFTIRKAFISASKQFGSIKLDELFEHTSLPSPFDLSPLDLEKSLLQAAMNDYVSFSIDHDAGVVSFMEDPFELLGGSTATNADDEQRNDDGYEETHVEEEPEPILTRNSAVRTQLIELAKALKETEGFPHASYVDKVRMARNELIRQNNAIIASEKEAAEERARQLEYEKQSASGVPLTAEQVVEERQRRMKEEKEAAEARMEAEARRRAEEKRERELAAINEKTMLKMIEDINAKGLIFIDPKEAKNMTLEKFKKLTVELVSKDKKDLDERMSHAFKRVDHIERAYRKLEAPLWEKDAQKQKERDLESYNKLKQMMVEKAKKDHEENLRIHDRLVKIYPSYLHFREKVIAAQKSQIEALRAENAAKLEAAKNARLQEVRQQRYNELIARRKEELAAKEHDDRQRMLQDRLTKERKERERVNKEKDEAARKQREIEEAVERTIKRNVSATPAPPVRSAPPARAAPPPRASNEQVASPAPQPEKKLTYAEKMKLRRAGRA
The following text describes a protein:
Function:
GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Sequence:
MSSGSPPPGPKPKSAIPPHLLNGSSPLHPSNSTGGRDARERESLNSSIRSSFAPRIPAEFHLPEIETHHVSDAADTYNGPVRKSGVIRPTLSDPPRDPRDEGGALTPPASSSRPSSPYTANPPIDFDGLSWPCPGTRARLESTPEQTEERIQKLAGAVRTIFECIGEDPEREGLRETPERYAKAMLYFTKGYEENVRDLVNGAVFHEDHDELVIVKDIEVFSLCEHHMVPFTGKMHIGYIPDRRVLGLSKLARLAEMFSRRLQVQERLTKQVALAISEVLKPRGVGVVMESSHLCMVMRGVQKTSSTTTTSCMLGCMRSSAKTREEFLTLLNRK
The following text describes a protein:
Function:
Serine protease which activates lin-3 isoform a in the proximal vulva precursor cells (VPC) during vulva development to transmit the inductive anchor cell signal to the distal VPCs.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MFSSEGKFRKTYRHQFNQLRTGDETEIPMSTLASRIETRKIPLTNGQIHAIKEAPDELVDIDGFQKIVTSKAAQRSTIKRIMYDMADPIMSDSQKIEVHSYIDSYSWCPPPIFMLLITIIQVGIFFFYWESDGGRSIWTDCAGCFVHHNHTAPGIFIFAPKLRGEAWRFTSYMFLHAGLNHLLGNVIIQLLVGIPLEVAHKIWRIGPIYLLAVTSGSLLQYAIDPNSLLVGASAGVYALIFAHVANVILNWHEMPLRWIRVLVLFVFIFLDFGGAIHRRFYTNDCDSVSHLAHIAGAVTGLFFGYVVLYNVVEHRIEKIIRYVCLFLYSAFFATTIIFVIVRQPYSKNLWNNENCS
The following text describes a protein:
Function:
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAAAAGGVAGEPSGTRTKQLKVAVIHPDLGIGGAERLIVDAACQLAVHGHDVHVFTSHHDKNRCFEETVSGPFEVKVYGDFLPRHIFYRFHAICAYLRCIFVAMCVLLWWPSFDIILVDQVSVVIPLLKLKAKSKIVFYCHFPDMLLAQHTTMLRRLYRKPIDMIEETTTGMADLILVNSKFTATTFARTFCSLHARGVEPAVLYPAVSVEQFQEPHAYKLNFLSINRFERKKNLGLAISAFSLLRSVASMLPGDARQEVTLTVAGGYDKRLRENVEYLEELKRLAASEGVSEHVKFVTSCSTSERNELLSNCLCVLYTPKDEHFGIVPLEAMAAYKPVIACNSGGPVETVINDETGFLCEPSAPEFSKAMLKLVNDHDLAVKMGKQARGHVVQKFSTKTFGDLLNSYVLNVYHQRIE
The following text describes a protein:
Function:
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide. The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN. Requires the flavin reductase RutF to regenerate FMN in vivo.
Sequence:
MQNAAPRLTFTLRDEERLMMKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHLPVLTQEVA
The following text describes a protein:
Function:
Negatively regulates telomere length. Appears to play no role in transcriptional silencing of telomeric loci.
Subcellular Localization:
Nucleus. Chromosome, telomere. Note=Localized to telomeres. This interaction may be increased by perturbation of telomere structure, for instance by loss of the rap1 protein.
Sequence:
MTKEIAVKEASNMLLQEPSTPSSQAVGLSSSPSSSIRKKKVNFSSELENSPGGNRPSFGLPKRGILKTSTPLSSIKQPNFQSFEGNESEKETSLQELQSSFCSGIENLQHVEKSARIETYSKLSSFLKIYTPSLPEDPIFPLLNQLCNFLLSDRCSNNSEGSPDFQLNTQANKLLSILLWHPTISSHIQPETATVFIEQSLNFLEGPKLTKALAAQHLHLLSCQKCPLSIHPLCNRILDVCFNISFPSLVIGQERLAVLTKILSQFPLEFSRRVVDWAPYLLACLVDASRPIREKALLLALDLSKHLYHDKLVARTILANFRSDIKGTAFVLIMTEQFEKLVIEEDDGVYVAHAWAAIISVLGGARISSWEYFNTWLKIIQLCFNSMNPLTKCAAQTSWIRLIHEFSLSETLTQATKRLTLLCQPISMVLGSRNLPTVKNAAMTTLIALIYACLRPGISDAMLSLLWDSVIVNILEKCALKNEVTIFESSNILLALFNTLSNGVWKDDRLVCRESVEAKELPKLNPVWVRANCSRTIEPVKTLLLLAKPDHTVKTTTPARKQHIRGLSYEQSSSVWSTYIKCLASAGQKEIKRSVETGRAICCICSSLHKFLYSKSIRKDELYVERVSRFALMVKSAIEAFGINTFVEASYLVSDNQLVLIDQTKAIDSYDHVPISPLIYLLHSLALLTNGTLFSTVHAAYSSILSSIEEYHLRFGLKLMLLWDCVSPLSDDGTLVLARVLVSHEVSRLTSEALLSELKSRNGNNSVEEGFSEEERSILLKLLSWNVKFCSISDAGSVNNLLQQYFTAIYKFEGCGSVFPFVVDPFTTILDDVLSFEANKVYSFAISLMKVSTFESCTKELPPVTLPENIRQHLDSYNHMVELYNTLLQRLSSSDQVDLQCRYLHELSEFIKKIPKEFIFHTICKLSKGLIPCFLMNAFPQLEKSTTLQKSCTNFCILILQLLLNSTATASNILESLSPLLTSGLKSISKEVVLAAIKFWNQVFGKFESEEYPIELQKTISYLSKTYIILLPFQSLCPGGKQANHQSSEKMSDILKGVDELRSVSKNGPYASSQDKGEKTTEFSGPGKPNNDNYIQIASVQELDDSSKGKAGKMPASKKNKRQKGDVKKIDETKNEATDMEESLTTPSGKVNKEVIVDDTSLRDEAIVPDKAIDVADNSNALLKENISSQSNRKADNNGTPSVNNSFTTANNDECSKENSQIEPEGQTASREGVLSTPRSTRKKRKLGRKSQSSNVNKEVAISEVSATLENVEVIERHGISEQGQNLDESACVLTNESSLSQTEIPEEKTENETTAVNGFENSKKRQFSSLLSGSIDTNNESNKVSSVEFDKSGPQDIIQSMTEATFEIEKNIQDLKSEEVQKLSDLLMRLQRAILSRIA