lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the transport of CDP-ribitol. Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSVEDGGMPGLGRPRQARWTLMLLLSTAMYGAHAPLLALCHVDGRVPFRPSSAVLLTELTKLLLCAFSLLVGWQAWPQGPPPWRQAAPFALSALLYGANNNLVIYLQRYMDPSTYQVLSNLKIGSTAVLYCLCLRHRLSVRQGLALLLLMAAGACYAAGGLQVPGNTLPSPPPAAAASPMPLHITPLGLLLLILYCLISGLSSVYTELLMKRQRLPLALQNLFLYTFGVLLNLGLHAGGGSGPGLLEGFSGWAALVVLSQALNGLLMSAVMKHGSSITRLFVVSCSLVVNAVLSAVLLRLQLTAAFFLATLLIGLAMRLYYGSR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
METNKQMEKSSNEEREEEVQELPPDDLNEQEEEQAMSEEDEGDTAETEAQHQMKDDGHDMEEEHGAADLIVLKEETHQWNEMEEKQQEIMTDEKPTLTKKTLSRGRSRKSKSRCNYSCKQSRKSFCQKPNLDVHTRKKPYTCKQCGKSFYNTGNLTVHMRIHTGERPYTCQQCGKSFYSTGNLAVHRRIHSGERLYSCPQCGKSCKQNGNLETHMRTHTGEKSFICTQCRKGFSQKQNLTILMRIHTGEKPYTCTECGKSFPHTGSLKHHMISHTGQKPFACAHCGKSFTTKTSLMNHMNGHTGTTCDQCGKSLPCKDSIKQHMKTHLGERFRCSECGKVFKHKRSVINHMKLHNGEKK
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MERKRYSKRYCKYTEAKISFIDYKDLDMLKHTLSERYKIMPRRLTGNSKKWQERVEVAIKRARHMALIPYIVDRKKVVDSPFKQH
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MPPKRAVVTLAEKKARVLKFFQEEHSIYSIKDLEKLIPKKCAGVSSMLVKDIVQQLIDEDGLISVEKCGNVNVYWCFKNQLVGKMCTEMQAMKARSEESQVRLQELQAAINSEKKHARAAAFRSEGVSYTRAALLTEHDELGRQLAALQSAYRKLEDTKWDETKIDSYCRGVRSKLEQLDKITDNIEVIVSFLMRRHAVSRAELAAALDMPEEFEEFEDLRKSLP
The following text describes a protein:
Function:
Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).
Sequence:
MPVRASIEPLTWENAFFGVNSAIVRITSEAPLLTPDALAPWSRVQAKIAASNTGELDALQQLGFSLVEGEVDLALPVNNASDSGAVVAQETDIPALRQLASAAFAQSRFRAPWYAPDASSRFYAQWIENAVRGTFDHQCLILRAASGDIRGYVSLRELNATDARIGLLAGRGAGAELMQTALNWAYARGKTTLRVATQMGNTAALKRYIQSGANVESTAYWLYR
The following text describes a protein:
Function:
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).
Miscellaneous:
MISCELLANEOUS: Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.
Subcellular Localization:
Secreted.
Sequence:
MRQAGRAALLAALLLLVQLCPGSSQRSPEAAGVQDPSLRWSPGARNQGGGARALLLLLAERFPRRAGPGRLGLGTAGERPRRDNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system.
Sequence:
MPNDKLTYRRGEIRWMRLDPTLGAEIQKTRSWLIVQDDVMNQYGLLTVVMPFRPGSRKAPYVVNVQASAQNGLDQDRFIDVGQIRSIDHSRVLERIGVLEAQYWPAVRSALDLVLGFEP
The following text describes a protein:
Function:
Seed storage protein (Probable). Globulin-like protein that acts as a zinc metalloprotease. Cleaves specifically between Leu-15 and Tyr-16 of insulin B chain, and Gln-1 and Leu-2 of neurotensin (NT) peptide in vitro. May play a role as an initiating endopeptidase in germinating seeds (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MAKKKTSSSMARSQLAALLISLCFLSLASNAVGWSRRGEREEEDERRRHGGEGGRPYHLGEESFRHWTRTRHGRFSVLERFPDEQVVGAAVGGYRVAVLEAAPRAFLQPSHYDADEVFYVKEGEGVIVLLREGRRESFCVREGDAMVIPAGAIVYSANTHSSKWFRVVMLLNPVSTPGHFEEYFPVGGDRPESFFSAFSDDVLQAAFNTRREELEKVFERQREGGEITTAPEEQIRELSKSCSRGGGGGSGSEWEIKPSSLTGKSPYFSNNHGKLFELTGDECRHLKKLDLQIGLANITRGSMIAPNYNTRATKLAVVLQGSGYFEMACPHVSGGGSSERREREREHGRRREEEQGEEEHGERGEKARRYHKVRAQVREESVIVIPASHPATIVASEGESLAVVCFFVGANHDEKVFLAGRNSPLRQLDDPAKKLVFGGSAAREADRVLAAQPEQILLRGPHGRGSVSDM
The following text describes a protein:
Function:
Catalyzes the reversible phosphorolysis of glucosylglycerate into alpha-D-glucose 1-phosphate (Glc1P) and D-glycerate (also called (R)-glycerate). May be a regulator of intracellular levels of glucosylglycerate, a compatible solute that primarily protects organisms facing salt stress and very specific nutritional constraints. Cannot catalyze the phosphorolysis of sucrose. Does not act on other sugars such as alpha-D-galactose 1-phosphate, alpha-D-mannose 1-phosphate or beta-D-glucose 1-phosphate; in vitro D-erythronate can substitute for D-glycerate with a much lower efficiency.
Sequence:
MKQKITDYLDEIYGGTFTATHLQKLVTRLESAKRLITQRRKKHWDESDVVLITYADQFHSNDLKPLPTFNQFYHQWLQSIFSHVHLLPFYPWSSDDGFSVIDYHQVASEAGEWQDIQQLGECSHLMFDFVCNHMSAKSEWFKNYLQQHPGFEDFFIAVDPQTDLSAVTRPRALPLLTPFQMRDHSTRHLWTTFSDDQIDLNYRSPEVLLAMVDVLLCYLAKGAEYVRLDAVGFMWKEPGTSCIHLEKTHLIIKLLRSIIDNVAPGTVIITETNVPHKDNIAYFGAGDDEAHMVYQFSLPPLVLHAVQKQNVEALCAWAQNLTLPSSNTTWFNFLASHDGIGLNPLRGLLPESEILELVEALQQEGALVNWKNNPDGTRSPYEINVTYMDALSRRESSDEERCARFILAHAILLSFPGVPAIYIQSILGSRNDYAGVEKLGYNRAINRKKYHSKEITRELNDEATLRHAVYHELSRLITLRRSHNEFHPDNNFTIDTINSSVMRIPRSNADGNCLTGLFNVSKNIQHVNITNLHGRDLISEVDILGNEITLRPWQVMWIK
The following text describes a protein:
Function:
Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDEEQRIAEIESLASIFPDLLEETTDKQLVFKFDRDIGMTINLPEDYPSISPPIFELSGPYLRREQKEVLHNSLNDVYIENIGFPVIFNWISLVQDFIRDLPEEVAEPSHVADDVVTPMAEEIDDMNIRHGEVLTDRKSAFQAHLAEVRSKEDVDRVMRILKSNTKICRATHNITAYRYMTEINGKPIHHHDCVDDGEFGASSKMLELMDRMKADNVMVVVSRWYGGIHLGPDRFRHINNLTRQILSDNNYGPKKS
The following text describes a protein:
Function:
Transcription factor that may regulate root development.
Subcellular Localization:
Nucleus.
Sequence:
MGYTLQQILRSICSNTDWNYAVFWKLNHHSPMVLTLEDVYCVNHERGLMPESLHGGRHAHDPLGLAVAKMSYHVHSLGEGIVGQVAISGQHQWIFSEYLNDSHSTLQVHNGWESQISAGIKTILIVAVGSCGVVQLGSLCKVEEDPALVTHIRHLFLALTDPLADHASNLMQCDINSPSDRPKIPSKCLHEASPDFSGEFDKAMDMEGLNIVSQNTSNRSNDLPYNFTPTYFHMERTAQVIGGLEAVQPSMFGSNDCVTSGFSVGVVDTKHKNQVDISDMSKVIYDEETGGYRYSRELDPNFQHYSRNHVRNSGGTSALAMESDRLKAGSSYPQLDSTVLTALKTDKDYSRRNEVFQPSESQGSIFVKDTEHRQEEKSESSQLDALTASLCSFSGSELLEALGPAFSKTSTDYGELAKFESAAAIRRTNDMSHSHLTFESSSENLLDAVVASMSNGDGNVRREISSSRSTQSLLTTAEMAQAEPFGHNKQNIVSTVDSVISQPPLADGLIQQNPSNICGAFSSIGFSSTCLSSSSDQFPTSLEIPKKNKKRAKPGESSRPRPRDRQLIQDRIKELRELVPNGSKCSIDSLLECTIKHMLFLQSVSQHADKLTKSASSKMQHKDTGTLGISSTEQGSSWAVEIGGHLQVCSIMVENLDKEGVMLIEMLCEECSHFLEIANVIRSLELIILRGTTEKQGEKTWICFVVEGQNNKVMHRMDILWSLVQIFQPKATNR
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MLRCALTGEVPKIPVVTPQGIVYDKDSIEHQIQISPVCPVTDKSLTLADLIPLKIDMPVNKTQTVRNYSFGDYLLSLQNQWNSKQKELYETRKKLAQCERELAQALYETEAAKRVIARILSNEGERIYIKPTTNISAEENTFSSFIKKVSLQSISNLAFEQNFKEQYFPPALNILQGFSSYNLSHLTSILGGSAQFTALDQTIDNKLLIGTSESSIAIFDVHLKSVVQQIQVGSAPIVSIHNSRDYHYLVSDSDGVIYIYENYQNDKPYKIIKTEKKIVNCYFHPQIQHVIAVFDNGFEVIQINNSEVLVHTEIQHEITLSSLHPGGRYLATANSTDKSIRIWDLSGNNLLISEIETESEIFNLNFSFNMLHLTASTSNGLLFVIPSGKPEDLYSDYKTICFEIPSKSHFWHQNGLLIVSFGDTEGFIFMITDPLDVQLSQAVKFGLRAQPRAAVFGNGSYFVAAIGPEDEIQLFN
The following text describes a protein:
Function:
Acts as a negative regulator in plant response to changes in environmental conditions through the control of ABA-regulated gene expression.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Subcellular Localization:
Nucleus.
Sequence:
MGKARKHSRGRPSGFVPDYMQAVEPDEFVYSERMNSEASPPLKRRRFGLNGDNNGVSKEVLSLSKMSRSERKNLVHKLKMELQQVRDLSKKIASFSSDTVLLSPYNDHSCSDGPRRPPPENFATFVGSQGKKRPPVRSDKQRNKKGPSRLNVPTSYTVASVMKECETLLNRLWSHKSGWPFRTPVDPVMLNIPDYFNVIKHPMDLGTIRSRLCKGEYSSPLDFAADVRLTFSNSIAYNPPGNQFHTMAQGISKYFESGWKSIEKKIPMSKPPVIPLTSSASLESEIPFEVAPMRKKEAAMNDNKLRVEPAKLVMTDGEKKKLGQDLMALEEDFPQKIADLLREQSGSDGQSGEGEIEIDIEALSDEILFMVRKLLDDYLREKKKSMEKSEPCEMEIVHDSGFSNSPLQPSKGDLQIDEDVDIVGGNDPSVSSHPPLKIEKDAACRNNESSSSSSSSSESGSSSSDSDSCSSSGSETDSIKASKPTSREEKKQPGVGIDKKEDDSNSEKIVVNDSLNELDQLEHTVGEKSTTMDAVVLVPDEETAPPERQISPDSPDKRYRAAFLKNRFADTIMKAREKAFTKGEKGDPEKLRIEREEFEKRLREEKERLQAEAKAAEEARRKAKAEAAEKARREREQEREAARQALQKMEKTVEINEGIRFMEDLQMLRATGTEGDQLPTSMEVMSPKFSEDMLGLGSFKMESNSNPLEHLGLYMKMDEDEDEEEDPPHFSQRKVEDNPFDRSEKQEHSPHRVEGEDQLVSGNEEPVSQEAHDNGDQEDGKPINPNEIERQLENMPEQESGVGDKEEQETEVVDMRKQENEVVDMGVEEVHPLDRSEGRTLSPHRKEREDPRASGNEESVSEKAQDYENQRDEKINQSEREEQLENVLEQESSRDDDTGEQETEVVGVGKELSLDKSEGQTLSPHREEGENQLDCGNEELVSQKTQDNGNQEDEKSINKIEGEEQLANVPEQESRVTEKEEQETGVVDLGEQKSEVVEKGVEENEAVDNGEGVQGTEVSDKGGNETVVDGNGKVETEVVDKAGQKTDLVDQGEEDIDVEID
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
Sequence:
MKKIRLALCQINPIVGDIEGNFSKILSFKEKAVKEKADIIVFPELILTGYTPEDLLFYPSFIKKANEALNKLIENVKDFVMILGLPVKEEDLYNSAVILAEQKVIDTYHKIYLPNYSVFDEMRYFKSGKRASVYEYSGVLFGVNICEDIFHPTLPSPIQASSGAELIINISASPFYAGKFEKKLRMLSTRAYDMGVFIAYLNTVGGQDEIVFDGRSMVISPSGEIITMGKAFEEDFIVVDLDLEEVTRVRMREPKIRWESEFERAEIIKISGEQKKSLAVQSLQPSAFSLKILSEEEEIFKALKTGLRDYVEKNGFSRVCLGLSGGIDSSFVALVATDALGSDRVTGVFMPSRYTSRESKEDVYELVKNLGIELIEISIDEIFEEYLRRLADTFKGLPEDTTEENIQSRIRGNILMAISNKFGWLVITTGNKSEMAVGYATLYGDMAGGFAVIKDVYKTQVYRVAKWASRDRIPERIFKKPPSAELRPGQTDQDTLPPYEILDEILKRHIEKCMSEEEIVEQGFDRDTVRKVLRMVKKAEFKRRQSPPGIKISPVSLGKDWRFPITNRFGE
The following text describes a protein:
Function:
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Sequence:
MLRTEWIARRHGHANVSQMYYARQGLITEEVAYVAHRENLEPELVRSEVARGRLIIPANTNHPNLEPMGIGIATRCKVNANIGASPNASNLGEEVAKLELAVKYGADTVMDLSTGGGDLDAIRSAIIQASPVPIGTVPMYQALEAVHGNVEKLTPEHILDVIEKHAKQGVDYMTIHAGILIEHLPLTQGRLTGIVSRGGGILARWMLAHHKQNPLYTHFDEIINIFKKYDVSFSLGDSLRPGCQHDASDAAQFAELKTLGELTRRAWTHDVQVMVEGPGHVPMHQIEMNVRKQMQECSEAPFYVLGPLVTDIAPGYDHITSAIGAALAGWYGTAMLCYVTPKEHLGLPNAEDVRTGLIAYKIAAHAADIARGRPGARDRDDELSRARYNFDWNRQFELSLDPERAREYHDETLPADIYKSAEFCSMCGPKFCPMQTKIDSQALSELEAALKPQPVAAQE
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDAGEKEVKREDNNELMNKGSRHQKPMKRISSSDSFKVEGNDKSEERVRHSLLLEGTEEMEWDDELCSNGSSSLGQKKRRLSVDQVKALEKDFEVMNKLDPERKVRLAHELGLRPRQIAVWFQNRRARWKTKQLERDYGALKARHDALKLDVDALRGDKEALMDEMRALKAKLADPATPKVEEDGRALGFRDGTSDTDSSAALNEEASPYSGALLDQHHSVLETKSHCSSIFMEEDGFLRGEELCGALFSEEQAPTLPWCCTEGWE
The following text describes a protein:
Function:
Transglycosylase involved in peptidoglycan cell wall formation. Required for the regulation of cell length. Plays critical roles for the survival of the pathogen inside the host. Required for both bacterial survival and formation of granuloma structures in a guinea pig infection model.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQDQGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLVDNEIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPALLPAALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGMTLPRPRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTLFAAGTLVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQPDTVPAASTDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLSSTLAIQLFIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRTRPRNKSPITAAGTEVIERV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MGRAISVLLQPRWLLIFLGVLAVTFIASYIFQKEHEEVDEVYEITHRVFLDVDIDKQRVGRIVIGLYGQVVPKTVENFRALCTGEMGKTADGVSLHYKGKPFHRIIPGFMIQGGDIVSGNGRGNISIYGGPFPDENLKIKHSHAGVVSMVNSGRNSNGCQFFIPTVKASWLDGEHVVFGKVIEGMDTVYAIEGGAGTYSGKPRKKVIIADSGEIPKNKWDEDSQSSTS
The following text describes a protein:
Function:
Acts as a ligand for KLRK1.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MEGGVQAPSLAGRPSRVAVILTEGQASYKVPDNCWSYSVGDRHFRESLSGILCGAAQNPHGFSQLRSHLLLMAGMAENTAAEHPLFTGASCVLVFLSCLGSTLCADVHSLSCNLIIRSPTKAEPLWYEGQCSMDGNVFLSSNNVNKTMPLGNQEKMANATEVWTCLTQWIDRCKQDLRDKVSEIKGDTTKTSGHPTLRVTMLSNHSHEQIIGASCVFNISENYSFILDLKTMKWKLINPVPEDIMKEWKDDKTLMKHLNLFIVECSPKFNEFLNQHEERTRSTTRAPDITQPPPTSQVPYKEVLIPVGLIISIIFIIFLCICVKRMCCPHGGRELQLLKDYCINWHKPQRNEGLEETKGEVPNQRTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS
The following text describes a protein:
Function:
Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience. In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons. In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits. The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior. Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2. Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1. Can activate the CME (CNS midline enhancer) element.
Subcellular Localization:
Nucleus.
Sequence:
MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTMPSALDADRLFRCRFNTSKSLRRQSSGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPGPASLFLAMFQSRHAKDLALLDVSESVLIYLGFERSELLCKSWYGLLHPEDLAQASSQHYRLLAESGDIQAEMVVRLQAKHGGWTWIYCMLYSEGPEGPFTANNYPISDTEAWSLRQQLNSEDTQAAYVLGTPAVLPSFSENVFSQEQCSNPLFTPSLGTPRSASFPRAPELGVISTPEELPQPSKELDFSYLPFPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPPPSSSLQEQLTPSTVTFSEQLTPSSATFPDPLTSSLQGQLTESSARSFEDQLTPCTSSFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLNSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYTEKEQNEIDRLIQQISQLAQGVDRPFSAEAGTGGLEPLGGLEPLNPNLSLSGAGPPVLSLDLKPWKCQELDFLVDPDNLFLEETPVEDIFMDLSTPDPNGEWGSGDPEAEVPGGTLSPCNNLSPEDHSFLEDLATYETAFETGVSTFPYEGFADELHQLQSQVQDSFHEDGSGGEPTF
The following text describes a protein:
Function:
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MHCWCLQGAAFLPSILVIWSSAGFLFSYIISVLIGHVPPFVPYISDTGTSPPESGVFGFMISVSAMLGAATMYTRYMILERQNLSIDFLPIYFNKISLAIGLFGCIGMGIVATFQEMAVPAVHDAGALITFICGVMYILLQSYISYKSCPTWNTRATCHIRMTVSLIAFIAVVPMSVFSILSGRKRLDWKPSDEGYPYHLTSAICEWTVAFGFNMYFLTFIRDFQGVSIQISTEIHEDF
The following text describes a protein:
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein.
Sequence:
MEASDNRLSDLVGALKSWVPRRSEPANVSRDFWMPDQSCRVCYECDSQFTFYNRKHHCRFCGRVFCAKCTDNWVTPQSTDSDTIREDSGKIRVCNYCFKQWQQGGLDTSVNHGIQVTSLDLITSPSTASLVSTKSSGTADSSFVTCTSFPHSVDSYQQNPNHSGISPRQSSVMESNLNDEFTVDNSYYDELQLDDVSNDYGSRKVHPDGEEATVAKSESSSSLQNSFDSRYFEKKEDEPDVNDECEASSSSLYAAQEIESEPVDFENNGVLWLPPEPEDEEDEREPLLFDDDDDGDGAGEWGYTRSSDTVGSGEFRNRDKSNEEHKQAMKTVVDGHFRALVSQLLQVENLSVGEEDDKDDWLEIITSLSWEAASLLKPDTSKGGGMDPGGYVKIKCLATGRRSDSMVVKGVVCKKNVAHRRMTSRIEKPRFMILGGALEYQRVSNLLSSFDTLLQQEMDHLKMAVAKIDAHQPDVLLVEKSVSRYAQEYLLAKDISLVLNIKRPLLERIARCTGAQIVPSIDHLSSQKLGYCDLFHVEKFVEEHGTAGQAGKKSLKTLMYFEGCPKPFGCTILLRGASGDELKKVKHVVQYGVFAAYHLALETSFLADEGASLPELPLNSPLTVALPDKASSIDRSISTIPGFTLPPNERSDKYTETERSNNAPMADVFSSIMSQKAQVMLMPLGSNTHNHQVSLDLPIETKDSADVTANGFGHPHPQHSLVKSSHNIDDGLYLQMDGKNGKEESVSSKEEFPPTPSDHQSILVSLSSRCVWKGTVCERSHLFRIKYYGNFDKPLGRFLRDNLFDQGYRCPSCEMPSEAHVQCYTHRQGTLTISVKKLPEILLPGEKEGKIWMWHRCLKCPRVSGFPPATRRIVMSDAAWGLSFGKFLELSFSNHAAASRVANCGHSLHRDCLRFYGFGKMVACFRYARIDVHSVYLPPAKLVFKFENQEWIQNELNEVVSRAELLFSEILNALSQIAEKNFGKSSVNSSSPSRRQIADLEDMLQKEKAEFEESLEKILNQEGRKGQNMIDILEINRLRRQLLFQSYVWDHRLVYAASVHSNSPRGDLNESRSENNDSYKDSDVTETQPQVMSKDTEDSDHENSDPSTSHDVGVNRSFSEGQLSVMASLSDTLDAAWTGNNHTGVQKDNTLSVISDADVADSSVADRVEESKSSLSSPSLSTRNSESIDEATSWFSMPFLNFYRALNKNFLPSSQKLDTLNDYKPVYISSYRESELQGGARLLMAVGVNDTVVPVYDDEPTSIISYTLLSADYISQMSGDFERLRDGEASSSSSSSIFTSQSADPVMFQSFSNFDETTLESLRSMGDESLMSMSASRSSLILDPVSYTTALHARVEFTDDGPLGKVKYTVTCYYAKRFEALRRICCPCELDYIRSLSRCKKWGAQGGKSNVFFAKTLDERFIIKQVTKTELESFIKFAPAYFKYLSESIGTGSPTCLAKILGIYQVTKQMKGGKESKMDVLVMENLLFGRNLTRLYDLKGSSRSRYNPDSSGSNKVLLDQNLIEAMPTSPIFVGNRAKRLLERAVWNDTAFLASIDVMDYSLLVGVDEEKHELVLGIIDFMRQYTWDKHLETWVKASGFLGGPKNASPTVISPKQYKKRFRKAMTTYFLMGVVGVRKGNPFVDGTSLDPLSKLNLKETSDFVKSFPANKGGGGGGGAAGNNKRNVVEAPSTPGRPVFSFSVGNNTSRKNFVPSKWNDAEKWLVSDHESTTHHHHLNGFVKSADFVSRKSSSSSNGSHVTKQQIKVVSEKPAEKASICQEHRHHNGNGTSPSESFDVLKDKFTNEVVRNFPKLECSEPLNESFLFKDPSSRDIGTEMTPLGSSTTSRCPTPFKSLSPPRHNTPASRSGPLDPNIKSSFDNIGGLQDLNLAKFKLGTPFDLVVSNWSSREEEEEEISKSLRHFEMNYECRTSISEPRPSVWEEEEKTKCCLRYQREEAKIQAWVDLQNAKAEAQSRKLEVKIQKMRSKFEEKMMRKMALVHRKAEELRAAAQIEHTEQIEKATTEQAKKKTINQHQNMHFSGHSGSCGCFPCNNLHP
The following text describes a protein:
Function:
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane.
Sequence:
MIENYILDYSGLKIFMATMSIIGVFVFIALYFINAGYGKFASRSWGPAIPNKIAWILMECPVFFVLCILWYFSERRFKLIYLAFFIIFQIHYFQRSFIFPFLLKGKSYMPILIMLMGATFNVCNGYIQGCWLFYASPEGYYTNEWFCTPQFIIGTIIFFTGMFINIHSDHVIRNLRKPGDTKHYLPNKGMYRFVTSANYLGEIIEWFGYFILTLSPAALVFVWFTFANLVPRAHKIYDRYLKEFGKPVLEKKRVFPFIY
The following text describes a protein:
Function:
N-acetylglutamate synthase involved in arginine biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MSKLKTLNRQFISNLETHKVTTDAKRNLILSILKSTTTKREAKNYLTKYQNQFDFNDDLDFNKSIKIKNEQSSLTNRDSQRELFINRFLNQSNPFINVYDKEDVKLQKVPLRLAIFKIKFTKITIKQWKGIAETFKRLITLGISPIIMLDYDHLPSDSYKNNELYMINQGNKMLNYLGHPEEESDLKVTLLRSLFTSHKGVPTLDSLESILIPLYQGIIPIIQPIVYNADLSKQEFLASDKLLLGLSSALIEKRTTDLLSIEKIVMIDPIGGIPSIERHQTSHVFINLSQEYSDILSELFIGHIEPKYRDTHVDNLNTMNNVLSYINEKSGNDETTGIITTPEIMSINIDQLNPIIYNVLTDRAIISSSLPSTTNRTPHLSTTIIKKGVEVQIFDVDNYDKDLTMQNLFDDKLVNKEKLIDLLNDSFGKSLDVGPYLDRINKNIATVVIVGDYDGAAIITWEYSKGEKIAYLDKFAIAKKNQGLPGLADVIFKIILQSHPFELIWRSRKNNPVNKWYFERCCGCMSAPDSQWKIFYTGEVFDKKIDRFKRKLRHQNGVVDIDRKLQQYSEICEGITPSFK
The following text describes a protein:
Function:
May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). Does not seem to bind to phospholipids. Plays an important role in the vacuolar trafficking of soluble cargo proteins at the trans-Golgi network.
Subcellular Localization:
Golgi apparatus. Prevacuolar compartment. Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasm, cytoskeleton. Note=Associated with actin filaments.
Sequence:
MDFMKVFDQTVREIKREVNLKVLKVPEMEQKVLDATDNEPWGPHGTALAEIAQATKKFSECQMVMSVLWTRLSETGKDWRYVYKALAVIDYLISNGSERAVDEIIEHTYQISSLTSFEYVEPNGKDVGINVRKKAENIVALLNNKEKISEIRDKAVANRNKYVGLSSTGITYKSGSSASFGGSFQSGSSNFDSYKDRDSREDKNDYESFQKSRRGVKTEEQSYTSKKSFSRYGSTDHDNLSSGKKSPDSAKHRSYVSAAPSNNDDDFDDFDPRGTSSNKPSTGSANQVDLFGGDLIGDFLDSGPTETSSTNNNENFQEADLFADAAFVSASAQGAEFGSQTQKQVDLFSASEPSVTVSSAPPTVDLFASSESVVSPEAKISIPESMATPNIVDPFAAVPMDNFDGSDPFGAFTSHSASVSTGPQAPSVHGSATNTTSPLSFADSKPQHLQKKDPFQVKSGIWADSLSRGLIDLNITAPKKASLADVGVVGDLSNEDGNKASAASYYSGWSMGAGSGLGKTGLYSTQQQQQQQQQQQAPDISDDFFSSLSNQRYQSGGFKQ
The following text describes a protein:
Function:
The cytochrome b6-f complex functions in the linear cross-membrane transport of electrons between photosystem II and I, as well as in cyclic electron flow around photosystem I.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MALRCKTPAATCAARSRRSVRVSAHKGAFEQAQVAAAAFVAAAVIAAPANAGVVLQQPVLKKAFQDDTPAAPPPKREFRGLAPPALPQSDAPNVAAEKPKKAEVVESTSGGLDPRSVALPGALALTIGGFVAASKIDGSFNDWFMEAVVRDSNNYAGYEATLKSENGVTFPKVAAGGTKKVKAATGSKKGGFPFGGKK
The following text describes a protein:
Function:
A transcription factor required for the expression of the CS1 and CS2 adhesins of enterotoxigenic E.coli. Required for expression of pilins and some outer membrane lipoproteins. Represses expression of nlpA.
Subcellular Localization:
Cytoplasm.
Domain:
Has been crystallized in an open and closed form; both bind decanoate which changes position between the 2 forms.
Sequence:
MDFKYTEEKETIKINNIMIHKYTVLYTSNCIMDIYSEEEKITCFSNRLVFLERGVNISVRMQKQILSEKPYVAFRLNGDMLRHLKDALMIIYGMSKIDTNACRSMSRKIMTTEVNKTLLDELKNINSHDNSAFISSLIYLISKLENNEKIIESIYISSVSFFSDKVRNLIEKDLSRKWTLGIIADAFNASEITIRKRLESENTNFNQILMQLRMSKAALLLLENSYQISQISNMIGISSASYFIRIFNKHYGVTPKQFFTYFKGG
The following text describes a protein:
Function:
Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation. Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue.
Subcellular Localization:
Cytoplasm.
Sequence:
MPQIPVRDGLCRLSAYLEELEAVELKKFKLYLGTATEPGEAKIPRGRMEQAGPLEMAQLLVAHCGMQEAWLLALSIFERINRKDLWERGRREDLVRDTPPGGLSSLGSQSACSLEVFPGTPRKDPRESYRNHVRRKFRLMEDRNARLGECVNLSQRYTRLLLVKEHSNPTWAQQKLLDTGRGHTRTVGQQASLIQMETLFEPDEERPEPPRTVVLQGAAGMGKSMLAHKVMLDWADGKLFQDRFDYVFYIHCREMNQSASERSAQDLISSCWPEPGAPLQELLRAPERLLFILDGFDELKPSFHDPQGPWCLCWEEKRPTELLLSSLIRKKLLPELSLLITTRPMALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFHFVRDNEPLFTLCFVPMVCWVICTCLKQQLEGGRLLRQTSRTTTAVYTLYLLSLMQPKPGTPTLQIPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGVDVSSFLNMNIFQKDINCERFYSFIHLSFQEFFAAMHYILEDGESGSGPDQNVARLLAECGFSERSFLALTVRFLFGLLNEQTRSYLEKSLCWKVSPRVKAELLEWIESKAQSEGSMLQQGCLELFSCLYEIQEEEFIQQALSHFQVVVVSNIATRMEHMVSCFCVKNCRNVVVLHLCGAAYSADEEDGLRGAEGPQAPLAQPPERNILPDAYSEQLASALSTNPNLIELVLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCQLSGPACWDLAAALIANKNLIRMDLSGNGLGLPGIRLLCEGLRHPRCRLQMIQLRKCQLEAGACREIASVLSTNRHLVELDLTGNALEDLGARLLCEGLSNPVCRLQILWLKICRLTAAACEDLASTLSVNQSLVELDLSLNDLGDAGVLLLCEGLRHPQCKLQTLRLGICQLSSAACEGLSAVLQVNPHLRELDLSFNDLGDRGVWLLCEGLRHPTCRLQKLWLDSCGLTAKACEALSCSLGVNRTLRELYLTHNALGDTGVRLLCKRLSHAGCPLRVLWLFGMALNPMTHRRLAALRVAKPSLDLGC