lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulator of phospholipase D (SPO14) which is required for SPO14 catalytic activity in mitotic cells. Essential to buffer the toxic effects of C16:0 platelet activating factor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGDSNSSQEAYSDTTSTNASRIADQNQLNLNVDLEKNQTVRKSGSLEALQNAKIHVPKHSDGSPLDYPKLNTYTFVPTTVPPYVLEAQFDKLRLQDKGTVDGNVTDDKNLPKEFKWGQFASTIGCHSAYTRDQNYNPSHKSYDGYSLSSSTSSKNAALREILGDMCSEWGGEERLEGVLHSEIGANLEFNTTEERKEWLQYIEKVKDFYYGDNKKNPESPESVHNKVYKSDWVNELNKEREKWRRLKQRKLQQWRPPLTSLLLDNQYLILGLRIFTGILSCISLALAIKIFQNSRSNNTISESKIGQQPSTIMAICVNAVAIAYIIYIAHDEFAGKPVGLRNPLSKLKLILLDLLFIIFSSANLALAFNTRFDKEWVCTSIRRSNGSTYGYPKIPRICRKQEALSAFLFVALFMWVITFSISIVRVVEKVSSITNRN
The following text describes a protein:
Function:
Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Also associates with the TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation.
Miscellaneous:
MISCELLANEOUS: Present with 5590 molecules/cell in log phase SD medium.
Sequence:
MSTDVAAAQAQSKIDLTKKKNEEINKKSLEEDDEFEDFPIDTWANGETIKSNAVTQTNIWEENWDDVEVDDDFTNELKAELDRYKRENQ
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MLIEHERGFVLHARAWRETSLLVEVLTEQHGRVGLLARGVHGPRKQALRAALQPLQLIQFTAVQRGELAQLRQAEAIDTAPRLLGEAMLAGFYISELLLRLAPRHAPVPELFDCYAQARAHLASGAALAWGLRQFERDVLDGLGFGFDLQHDSDGQPIDPAARYRLDPQDGARRVLSERLAQDRRETVTGAALLALGEDRVPATEDMPGLRRSMRGVLLHHLSGRGLKSWEMLEELARRGA
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
Sequence:
MIDFMEYGLRKYYQTIGWNEDKYYTNLDAGPNRILVFPIPIGLNFALGKRISPVFKSAYCISIPEGRSAAFMYTSVPVDLPVLPVHEYYSTIVPSPKSYFPFMHKTIETDKANNESISTPVSNSNSYILFGRLFEDLHLEGLYSQLLSPQILLTASTLSEFKWKSDLEKDDFNANQCPACVYYTAKENSGGCKYSKVYCIAFLDTHVNLVTFIHLVSLGARYKKQYQEGVESILTLVANPIMGHLNSAYSTTVLKDMQMATRYSFNMYSFNADVSVGIEYAPVGRNQVLKARLSLEEGVALRFDGRFKDIMYSIGMSTGFGPDSKQFFGVQIQL
The following text describes a protein:
Function:
Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.
Subcellular Localization:
Vacuole lumen.
Sequence:
MKFSSVLVAFLASFVVAEEQPACGVPIVYRLFTQPELSAPLHKDCPANADLPLSCSKEITDKDSLCCVQQPGGLVLLAQFWDYDPGFGPEDAFTLHGLWPDNCDGTYQQYCDKEQEVSNVTDIIKKLEPSLLDYMNEHWVSDDGDNESFWEHEWNKHGTCMSTLNPSCYKEGTDKHQNVADYARTAIALQKELNTFGFLGSKGIWPSDDKTYPKQDIEAALKYHHSNSKVHIACDKSGALNEVWYYFHIQGAIPSAEYTPVDDTIPKNNCPDQVKYLPKKFNSTKPATGY
The following text describes a protein:
Function:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 and many other genes, upon ER stress. By activating the UPR pathway during non-lethal hypoxia pre-conditioning, confers adaptive protection to subsequent exposure to hypoxia. ire-1 and pek-1 are redundant genes that control a pathway essential for larval development and survival. Plays a role in the nuclear retention of unspliced mRNAs.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRATFHLFTFIFLLLFSSVICISTPGFRNDHESIGDDEEKTSSTILVSTIDGRLRALDSETGEIKWTLQEEPVLRSPSAVKQGFTFLPNPLDGSLYVLKNSSLKKLPFNIPQLVHASPCKGNDGILYAGSKKDVWFGIDPKTGLKVETLSSASADRICPANQKQTIFLGRTEYRVSMFDEKNRGKTWNATFNDYSAHLLPEVNTWPFKHYASSSHGYILTFDRETGEMRWEQDLKQPVVALYLLRDDGLHKLPFEVMGKETMENVAKNIFTVDQWPTVLGVNAADPQTTSLTNQFFPALFVGESSFGLYAIEALVDHQTITYSPKLLGPPLLEGPAPIALTEMEKEEYLPPRRPIIRNIPPSITHKTSDGEYLLLGYHDRPMMTMATIIPTRYPVPGPHKAIGSTIERPPPQLLGPVEPQKHEDTSFILLLLNNHPIPFYATLVTMFALLLTVIWQCGRQWDQQKSTSRMDSFEIVNNPGESRSAQTSKQSNRGSFGWANRKIEIPEGWMAVGSKLMYSPSDILGTGCEGTVVYRGTFDGREVAVKRVVSEFVKFAHREADLLRESDTHPHVIRYFCMESDSQFRYLALELCIASLNDYVEQKEVQQNVTIALRDIMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLISASTSYPVDIFSLGCIFYYVLTSGTHPFGKSLHRQANIVNGEYTLNKLADLDDWSLADDLISSMLNVEPLHRLTADAVLNHPFFWTSEKRLAYFSDVSDRVEKEEDNSPVVRRIETDARIVVCGGWREKICDALKEDLRKFRTYKSFSVRDLLRAMRNKKHHYRELPEDVRQSLGDIPDQFLHYFTSRFPRLLLHVYKATEYCSGEAVFKRYYSDDVRARMYPIVEEEERVRKKIKEEMANEVWARAPKPVEQRTPLKLDKRNIKKKSNPNTD
The following text describes a protein:
Function:
Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAPQYAPSLRSRLPLVAFLLETLFLLLFVFWVKIEKQEYRRSESEPFVHSYADFQDVHVMIFMGFGFLATFLVRYGLSGSGFNVLLAAMAVQWAVLMNGFLLPQHRHHRGQIHISMKSVIEAELSTASALIAIGAVHGKTNPVQLLLMSLVEVTGFVVNQWILRTLLHADALYSIMLLHIFGSLFGVMVSWVLHREGIKPHHEKEKTDRKTGLFAMFGTLFMWMFWPSFNSALLSSRWERALRLTVIYGTYLSLAVSVVVAMSVSMLTSSKGKMNMVHVQSSALSAGVAIGVAMTAVSEPWVAMVIGFCASLLSGLGFRYMKNHMLFAFECHDTCGVLNVHTIPGILGWFAHLCLRLASMEGTVAVQFAVYHICVLLITLCVCLVMGVATGIVLKWSIWRPQQDRKCFDDQAFWEFPNLVTKK
The following text describes a protein:
Function:
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity); The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Note=Its shedding leads to a soluble peptide; [Klotho peptide]: Secreted.
Domain:
Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 874.
Sequence:
MPARAPPRRLPRLLLLRLLSLHLLLLTLRARCLSAEPGQGAQTWARFARPPVPEASGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHPRAIPEDSPIVMAPSGAPLPPLPSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVWRLYNTSFRPTQGGRVSIALGSHWITPRRMTDYHIRECQKSLDFVLGWFAKPIFIDGDYPKSMKNNLSSLLPDFTESEKRFIRGTADFFALSFGPTLSFQLLDPSMKFRQLESPSLRQLLSWIDLEYNHPQIFIVENGWFVSGTTRRDDAKYMYYLKKFIMESLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIENNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDPTLSQFTDPNVYLWDVHHSKRLIKVDGVVAKKRKPYCVDFSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNRTVLHFYRCMVSELVHANITPVVALWQPATPHQGLPHALAKHGAWENPHTALAFADYANLCFEELGHWVKFWITINEPNSRNMTYRAGHHLLKAHALAWHLYDDKFRAAQKGKISIALQVDWIEPACPFSQKDKEVAERVLEFDVGWLAEPIFGSGDYPHVMREWLNQKNNFLLPYFTEDEKKLIRGSFDFLALSHYTTILVDWEKEDPIKYNDYLEVQEMTDITWLNSPNQVAVVPWGLRKALNWLRFKYGDLPMFVTANGIDDDPHAEQDSLRMYYIKNYVNEALKAYVLDGINLCGYFAYSLSDRSVPKSGFYRYAANQFEPKPSIKHYRKIIDNNGFLGSGTLGRFCPEEYTVCTGCGFFQTRKSLLAFISFLVFAFVTSLALIYYYSKKGRRRYK
The following text describes a protein:
Function:
Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MIPIRSSITRILPNGFLSKPFLRQLNKKSKPNPHKNKNFDSFNEVFIHKTLLSSIKQHNDTDYVRCSIFNANGDMIQHGKEILKSQFIKRYNLTPRDFRKFNWQRSATGTTTTSSSSSSSAGQTSSGTSKSSSSSSSSSSPHSTISALSLSNSSLGSSTNVDIVPNITIRRNSILVQLLNIRALINHDQLIIFDNSSSFQNSHVSSYTHSQCLKDLSQRLKSTNLDGLPFEFKALEGILIYIVSNLNMEMKVHNTVLQNIITGLEDSIDRNKLRYLLIESKKIHQFHRKITLIKNCLEDLLENDDELNDLYITEKFNSEGDGQPRQGTNHEEIEMLLENYYQTIDEIVQIVENLKNQIKTTEDLINVVLDSNRNQLMLLGLKFSTGLLSMGVALYVSALYGMNLENFIEEIDGGFEVVTVVSTIALIALLLFSVKQLKKVEKVTMTSLNDQRK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against trans-1,3-diphenylpropene oxide (t-DPPO), epoxyeicosatrienoic acids (EETs) including 8,9-EET, 11,12-EET and 14,15-EET and the linoleic acid metabolites 12,13-epoxy-9-octadecenoate (12,13-EpOME) and 9,10-epoxy-12-octadecenoate (9,10-EpOME).
Miscellaneous:
MISCELLANEOUS: Less active when compared to ceeh-1.
Sequence:
MGFFADLFKVVYSTWRQYIYTTGALLTLTWKWFTEGNEYFVEHVYPEPECLKNWNHKFVQLKNIRMHYVEEGPADGDVLLMVHGFPEFWYSWRFQLEHFKHTHRCIAIDMRGYNTTDRPSGISDYNLTHLVEDIRQFIEILELKRVTLAAHDWGAIVCWRVAMLHSNLIDRLVICNVPHPFAFFEVYNMSKEQRNKSWYIYLFQSQYIPEIAMRSNKMKMLEAMFRGSKAGIRNSENFTDEDMLAWKHVFSQPGGTTGPLNYYRDLFNAPAIPRKLQIVQPKVLILWGDEDAFLDKKGAELSVQFCRDCRVQMIRGASHWVQQDQPQLVNVYMEQFMNEDSYRPIGEIKTFKSHL
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAISDLLNRRVRAAPDEDEEVYSDESASGSEPPSDEGSSDESGSESGRDSLNGSDNDFDSESQNSEASDSISEDEDDDGDVKSSLNNISFGALAKAQASFAPQTKRRTKNLKDNEGTTASPLDDIRAKIQEAREQKRKASLASKDSSAKSRVDKPPPRTSKHAPTVQSSKYAVSRKRTIIEPPSVPKSRDPRFDPTIVGGRGGSGSSAPSDAYAFLDDYRAAELRALKEQLAKTKDVRRREALQREIRSMTDRLRTIENHKREKEILSEHKKREKQLIREGKKATPYFLKKSDIKKQALLKKYEGMKSKDRAKALERRRKKAAAKERKEMPMERRGLGGDSDAAPSKRRRMA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mL67/mhr1 also has extraribosomal functions, being involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells. mL67/mhr1 also acts as transcription factor involved in regulation of RNA polymerase II-dependent transcription.
Subcellular Localization:
Mitochondrion.
Sequence:
MLEKNKYLYIFRHIQTNQVLLSQGNVLKKTALFQLPYPLQKPVAPNGMRPAKLRKDHWVPLLKVEFPNESMFQSVFMQLLNYRKYRSVQPLTSDLLKLPIPVRRRKIMRQEVPNTIADLADILNKEKFPENSVRLQLSDKSDSEYADWPPSVQIDSEEIKLSRGFREKTTVDEAR
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus membrane.
Sequence:
MAAATDVSARAAAAASSTSPRTAASNSSGLAGKPPGPAPSSAGVAGAAGASSTGLPASVSHFYYKHGLFLSSYPTCASSIAFMAILLSCYPLINIPLPGTIPTKIVVPYETGSGSLSWHSLNTSSTTPQEPHPSGEPWPPEPQVLNSSTTDRSPPPLLPWAQSSPAFFYVQQITLRTSVLPWTEGMQLMDAFRAPLHEVFKLLEIVRNHQSSENKRTLEHNCLHVDNVKRGTHGQLDQIFPEYGCLLLSPANLWTQNSQNFTRDTNILNTIFQYHNLQKSKVSAAEMLFGLPMQDTGFKRYPLRARSRIIQYALTLFLKHNDMEYLDTLKEKLLRHYPPLPLASASAEEPTTITYIFYPGEYRMWELVPYTVAFMLVFAYVYFSVRKIDVFRSRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYLVILVGLENSLVITKSVVSMDETFDVKIRVAQALSKEGWHISKTLLTEITILTIGLATFVPVIQEFCIFAIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPKMLLSCTQGAGRQDFRFFGAAPALPPFVPGTFQRSQSHPKLCFADPASVSDRTSLVNGHSSPEQRIPKRIKIVNFWARTRFFQRAFMIWMIVWICSIVYNSGYLEQLFSMQSNGTMTATLELQRRLQAGRGAVSSFFEGWQADGQRATSAPSGSGFSTPIKAPLAIDINETAEEMMRLRYPSFDLNYFLSNFHWSTIMKQYNISLSGHYVTLLPTIRLSHAIAPELATLLRNPQEQLQQNFQWKALAAALDPLDFNDDDVRRESPMVMAEGLPLVPKSPMEIFFAILLCCISIFVLCYTMVVFYRCICTRNYAEWRSSWHESEAPYKQTEQILEGVPTQIAGHKHRIECLVSDGAYIISCCLKGQIRVWDARSGEQLTSISRSDIQISQQRTDGQTLVRKLAVSPVWCLDYFDNLIAVGCANGRVELWESPAGLLKCAYQEDAKRNQGITHIHLNGDRVIVARLNGRLDFYRLETYYKGKQIDWGFTSAYRRTHVRTGSTGSLGLMLQQQRCQQEASQKTTKEEMKITLEGVRLAHQQPITCMQVVNDMVFTGSQDHTLKVYCLNKSDVEYTLHGHCGPVTCLFVDRWQPGTGGSGSQDGLLCVWDLFTGACMYNIQAHDGAVSCLACAPSYVISLGTDERICVWERFQGNLLTTINISNAYSSLLMLTPSLLVTSKMGSLIVWDVRTGQPAREVKLDFANLQLCPKIMMLACDSVVCDYGNEIRVVRFPIVADKCH
The following text describes a protein:
Function:
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
Subcellular Localization:
Cytoplasm.
Sequence:
MNEPLASKKIRWKCRRGMLELDILLERFYEEKFRSLTKNEKEIFNQLLDQPDPLLYDWLLGHVTPESSEFKKIIRKIQQLSS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. Also has an extraribosomal function, being essential for mitochondrial genome integrity. May interact with MHR1 to take part in the mtDNA repair mechanism.
Subcellular Localization:
Mitochondrion.
Sequence:
MMIEIIPKISIPKNGLGSFTRPCRRIEFSYCNWGGSSKGMKEFLSTKLESLAKESQDVEFHVTNRQGKHPLIRAYYNTGREKVICTRKMSASSIFQKAILCRDSDGLKPRLIKYPVESTNPSVRGIWSPFSDQAKPHEIYKKKSP
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Subcellular Localization:
Nucleus.
Sequence:
MNSPNESADGMSGREPSLEILPRTPLHSIPVAVEVKPVLPAAMPSSMGGGGGGSPSPVELRGALAGPMDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLLGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGTGPGVSSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGSTLTGKFMSTSSIPGCLLGVALEGDTSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPEETEEELTEQQEALLGEGALTMPREGSTESESTQEDLEEEEDEEEDEEDCIQVKDEDGESGPDEGADLEESSAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKSPTDHPTVVKHLFTTGPISQKMYAMLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYDDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPSINAVATLEKVIEIQSKHWSCVQRFATGLGCSLREAQTGEKEEAETVSAMALLSMGAEQAQAAATQEHSPRPAEEPMEQEPAL
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MRALRLLATSGLDEHSGILASLSEHSASVNCVRWHPYRLLLASCSDDGLILLWQPMTGAFASNFGEEQSTEGWRPQTVLRGHGEIDIVSLAWSPDGDRLISCAIDHRILVWQTSTARKICELEGHDAPVRGISWDPLGAFVASQGEDQKVCIWDTTTWKQEAVVTEHFSQQGASGMFYRLDWTADGLGLIAVHGQNNHFPVAVSIDRKRSGYEQPLAAIRNLFSNSVTDIAWSPLGAGECVCVSVDGSVALISLSPGEIGIPFSNALQHKRLQELYGPGVFERPVMAANSAAFALARSVDAVAASHGPEADSPSRSSEPGRLEQHDGSPAAKRRLEPVSMGSSAAAMTYTHQRERRTSDNRRRIQPMVGIVSSTSTPLATSVVGNTSSDPAANSVITTTAQPVAHVAGPLVDLSAAALSDSFTCHVAADQTATTPKLRLEINNTWVKYTEHKKSHVMGLVQCFGPEENTAPLPSSSHGMAGDEAASSTQPTSATRSASQLDVTQAAPPTPIWEAVVGEKVACCATSTTVLALASQDGHLHFFSLQAGLRLSPPFRVAPFVALMRFVEDVLIVVTSSARVYAWRVDSKGALSKLYANVDLQPVLPGRSNSSTLAGVDLLDNTTLIVYLQMKGLAARHPFPSVLAPPRALSAAVQNTDSALLRLQSRVNVVAASATQMREAAALDESALRLVKVSQAEANVVTARVIGDVAAFEHAVLQFARICAEVGAVDPLRALCRGLLQRPPASPLEQACYSCTGCDTLLVLRRVLMLLASRSDQDALVEDMKELLDEAQASLEKGAARATT
The following text describes a protein:
Function:
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MWCASPVAVVAFCAGLLVSHPVLTQGQEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEKLKKLDSQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKYAATHPKTEL
The following text describes a protein:
Function:
Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB). Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine.
Sequence:
MASKLASSPNSLLLQNPIRQNLPLKPDSSAANFANFATQNKPISIRCSATSTAPVSSIPATQDPEGRVFNFAAGPAILPANVLKKAQAELYNWRGSGMSVMEMSHRGKEFLSIIQKAEADLRALLNIPEDFAVLFLQGGATTQFAMIPLNLCKPDDQVDYVVTGSWGDKAFKEAQKFCKPKVIWSGKSENYTKIPSFDGLEQSPYAKYLHICANETIHGVEFKDYPTPKNGILVADMSSNFCSKPVDVSKFGLIYAGAQKNVGPSGVTIVIIKKDLIGNAQEITPVMLDYKIHADNNSLYNTPPCYGIYTCGLVFEDLLAQGGLSEVEKKNTKKAELLYHAIDESNGFYSCPVEKSVRSLMNVPFTLEKSDLEAEFIKEAAKEQMVQLKGHRSVGGMRASIYNAMPLAGVEKLVAFMKDFQARHT
The following text describes a protein:
Function:
Component of the primary cilium that controls cilium formation and length. May function within retrograde intraflagellar transport (IFT)-associated pathways to remove signaling proteins from primary cilia. Also involved in neuronal vesicle biogenesis and neurotransmitter vesicular function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm. Note=Located in primary cilia, with enriched localization along the entire ciliary axoneme. Localized to the cytoplasm in neurons and appears to be vesicle-associated.
Sequence:
MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRDHQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPILSPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPKVTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPPTGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHLSSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVNRLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETADVSPNNVQV
The following text describes a protein:
Function:
Cell membrane polyamine/proton symporter involved in the polyamine uptake in cells. Possesses high affinity for spermidine and lower affinity for spermine and putrescine. Transports paraquat, a polyamine analog, and thus confers sensitivity to this chemical which is used as a herbicide.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Plasma membrane.
Sequence:
MADTGGRPEVSLATVRSPGHPAASTTAAAAADLGHADTGQEKPTVESAQPANGAAPMGECGTEYRGLPDGDAGGPMPSSARTVSMIPLIFLIFYEVSGGPFGIEDSVGAAGPLLAIIGFLVLPVIWSIPEALITAELGAMFPENGGYVVWVASALGPYWGFQQGWMKWLSGVIDNALYPVLFLDYLKSGVPALGGGAPRAFAVVGLTAVLTLLNYRGLTVVGWVAICLGVFSLLPFFVMGLIALPKLRPARWLVIDLHNVDWNLYLNTLFWNLNYWDSISTLAGEVKNPGKTLPKALFYAVIFVVVAYLYPLLAGTGAVPLDRGQWTDGYFADIAKLLGGAWLMWWVQSAAALSNMGMFVAEMSSDSYQLLGMAERGMLPSFFAARSRYGTPLAGILFSASGVLLLSMMSFQEIVAAENFLYCFGMLLEFVAFILHRVRRPDAARPYRVPLGTAGCVAMLVPPTALIAVVLALSTLKVAVVSLGAVAMGLVLQPALRFVEKKRWLRFSVNPDLPEIGVIRPPAAPDEPLVP
The following text describes a protein:
Function:
Involved in biosynthesis of the repeating tetrasaccharide unit of the O-antigen. Catalyzes the reversible epimerization of the hydroxyl group at position C4 of undecaprenyl pyrophosphate-N-acetylglucosamine (UndPP-GlcNAc) to yield undecaprenyl pyrophosphate-N-acetylgalactosamine (UndPP-GalNAc).
Subcellular Localization:
Cell membrane.
Sequence:
MNDNVLLIGASGFVGTRLLETAIADFNIKNLDKQQSHFYPEITQIGDVRDQQALDQALAGFDTVVLLAAEHRDDVSPTSLYYDVNVQGTRNVLAAMEKNGVKNIIFTSSVAVYGLNKHNPDENHPHDPFNHYGKSKWQAEEVLREWYNKAPTERSLTIIRPTVIFGERNRGNVYNLLKQIAGGKFMMVGAGTNYKSMAYVGNIVEFIKYKLKNVAAGYEVYNYVDKPDLNMNQLVAEVEQSLNKKIPSMHLPYPLGMLGGYCFDILSKITGKKYAVSSVRVKKFCATTQFDATKVHSSGFVAPYTLSQGLDRTLQYEFVHAKKDDITFVSE