lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Not yet known.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MPVKEQGFSLLEVLIAMAISSVLLLGAARFLPALQRESLTSTRKLALEDEIWLRVFTVAKHLQRAGYCHGICTGEGLEIVGQGDCVIVQWDANSNGIWDREPVKESDQIGFRLKEHVLETLRGATSCEGKGWDKVTNPDAIIIDTFQVVRQDVSGFSPVLTVNMRAASKSEPQTVVNASYSVTGFNL
The following text describes a protein:
Function:
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cell projection, cilium.
Sequence:
MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMGDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSSLSCRTTTRSPLRSRCPCPWRRCCLTSLPRHWICWVNSFSTLLTSASQLPRLSSISTSSQLPCLPIHLSCRFLSV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MIISFPLINLFLYEHENNLKNKVNTLTKREKQKKKNNTMAKTEERITDLESVKRYLEKKGEESAPTVDNELPQEFLGHLVVRGLRLDLIEPGRIVFSMKIPPNLLNSSNCLHGGAITTLVDLVGATAVPTAGFSWSSGVSVEINVSCLDAAYVDEEIEIDGRVLRVGKTIAVISVELRKKKTGQIFAQGRHTKYIPFISKM
The following text describes a protein:
Function:
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MLEAPSFDKMLGMFYYATDTCPSGGVIKRSPEDFVVEEVLLDGTVIATSGVELRPRVGNWTWIHVVKRNVDTIKLVLRLARALGLSHRDVSVGGLKDTKAVTSQIISVRGPVANLPQLPGVQFLGMWSMDKPITPSQIYGNRFTIILRDVERISCAEGALEALKKTAAPNYYGYQRFGTIRPVTHLLGKALLKKDPHLFFEVMFCKIFSRESEVAKRAREAACKGDYAKALELFPKKFVEERVFLKRLAGGYDMWNAIMAIPPQILRVYIEAAQSYIFNRFLSIRMEIGPIDRPVEGDLVEINRQIAYYAEGLGGEVVLPVVGAGVRMPRGKVGEALLRVLREEGLDPSAFLKMPRGLRVYGTYRRVRLEPAGFEYKIMGNDVFMQFTLPRGSYATVLLREVVKPAEPHKHGF
The following text describes a protein:
Function:
Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Contributes to efficient phospholipase D1 activation and phospholipase B1 inhibition in the regulation of phospholipid turnover. Forms a complex with phosphatidylserine decarboxylase PSD2 that seems essential for maintenance of vacuolar phosphatidylethanolamine (PE) levels. Allows interorganelle phosphatidylserine (PtdSer) transport via a process that involves the acceptor membrane complex PDR17-PDS2 that binds to PBI1 which in turn ligates to SCS2 and phosphatidic acid present in the donor membrane, forming a zone of apposition that facilitates PtdSer transfer.
Miscellaneous:
MISCELLANEOUS: Present with 5040 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Microsome.
Sequence:
MGLFSRKRDHTPAVPKEKLIPCDKIFLDPPAKYGNAPLLEPISEDQNEKYRAVLRHFQDDDLKLPENLNDLDNGTHANDRPLSDWEKFWLSRECFLRYLRANKWNTANAIKGLTKTLVWRREIGLTHGKEDKDPLTADKVAVENETGKQVILGFDNAKRPLYYMKNGRQNTESSFRQVQELVYMMETATTVAPQGVEKITVLVDFKSYKEPGIITDKAPPISIARMCLNVMQDHYPERLAKCVLINIPWFAWAFLKMMYPFLDPATKAKAIFDEPFENHIEPSQLDALYNGLLDFKYKHEVYWPDMVKKVDDLRLKRFDRFLKFGGIVGLSEYDTKGQHDELKYPVDMVI
The following text describes a protein:
Function:
Transcription factor which binds the DNA motif 5'-[CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer. Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. Promotes male-specific development of two tissues, the peripheral nervous system and the intestine. In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, causes repression of vitellogenin gene transcription.
Subcellular Localization:
Nucleus.
Sequence:
MLTEDPVSEICEAKAVDELAEQEKNYYCQRCLNHGELKPRKGHKPDCRYLKCPCRECTMVEQRRQLNNLLSKKKIHCTPATQTRDGKRVRDPHCARCSAHGVLVPLRGHKRTMCQFVTCECTLCTLVEHRRNLMAAQIKLRRSQQKSRDGKEPKRNSRRKSKDMDMEMMVVTATDGQKIIGTSASPSPSSTTDTMSPSLSMSPPCSPSPLLAQYTLTLAAPIPIYPPIPMNQQLISLQQQQFLMSIIQNMAPSIGQQAPLLPGISAGSVSSAAILNEFWSMYLKNYGLQA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLVFLPPPKATLATTDGATATSVPGGPETRSGSERGGGRRRLSCAARRRAARRGGSVSGWSAGRTPTETSNPGSSVMESVTLEDVAVEFIQEWALLDSARRSLCRYGMLDQCRTLTSRGTPPCKPSRVSQLGPRAEPRATERGILHATGVAWESQLKPKELPSMQALLEEASSRDMQMGPGLFLRMQLVPSVGAKETPLTQEDRPALQEPPWSPGYTGLKAAVQIQRVLIPVPTLGHPDPGVAGDSAVPARDPAWLQEDRVEEEAMAPGLPTACSQEPVTFADVAVVFTPEEWVFLDSTQRSLYRDVMLENYRNLASVADQLCKPNASSYLEQRGEQWTTDRGILADTCAEPQLQPQEAIPSQDPFTEILSIDVKGEQPQPGEKLYKYNELEKPFNSIEPLFQYQRIHAGEVSYECQESRNSFFQSAHLIVPEKIRSGDKTYACTKCEKSFRYSSDLIRHEKTHTAEKCFDCQECGQAFKYSSNLRRHMRTHTGEKPFECSQCGKTFTRNFNLILHQRNHTGEKPYECKDCGKAFNQPSSLRSHVRTHTGEKPFECSQCGKAFREHSSLKTHLRTHTREKPYECNQCGKPFRTSTHLNVHKRIHTGEKLYECGTCGQVLSRLSTLKSHMRTHTGEKPYVCQECGRAFSEPSSLRKHARTHSGKKPYACQECGRAFGQSSHLIVHVRTHSAGRPYQCNQCEKAFRHSSSLTVHKRTHMGRENIRNGSLPLPMSHPYCGPLAN
The following text describes a protein:
Function:
Has antibacterial activity against the Gram-positive bacterium S.lutea (MIC=1.9 uM). Lacks antibacterial activity against the Gram-positive bacteria L.monocytogenes and M.luteus, and the Gram-negative bacteria E.coli D31, E.coli ATCC 25922, and S.typhimurium. Has antifungal activity against A.niger (MIC=2.9 uM), C.albicans (MIC=2.9 uM), C.fructus (MIC=2.9 uM), C.wickerhamii (MIC=2.9 uM), P.pastoris (MIC=2.9 uM), P.stiptis (MIC=2.9 uM), P.tannophilus (MIC=2.9 uM), T.harzianum (MIC=2.9 uM), and Z.marxianus (MIC=2.9 uM), but lacks antifungal activity against C.albidus, F.oxysporum, and S.cerevisiae.
Subcellular Localization:
Secreted.
Sequence:
DKLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFWNVNCWCEE
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.
Sequence:
MEQISLVKENVEEKKKKVHCSIPKFILENKLLEKAIKKCLPENYNFEVYKCIDIILREKYKRIALQLPEGLLVWGLYLSEIFYFFCESVEEVIILGDVTYGGCCIDDFTSGKLNCDLIIHYGHSCLIPLTVTKIRCIYVFVDIKLNSTHLVDTIKKNFDKNDIILLLGTIQFSCIVHNVHNILKKENYFHTFLPIPQVLPLTKGEVLGCTSPNLYEFLYEHIIKYERDKKYSELEKEKGEEGKNKETQEKRDNINNIILVNKMKESLNEHDIRKECQIFLKKKNVKIIFIADGRFHLESVMIHNPDFLFYRYNPFDKIITEEKYDYKLFYDIRKNEIKKCVNCKSIGIILSTLGRQGNVNILTNIINIMKKKNISFFILLLSEIFNEKLQLFQNVDLFIQIGCPRLSIDWGNYNLKPLLNTYEAYVLLNSVPYKDIYPMDYYSHKGNIWTNYAAGVGFYNEKNLTTKEIIRRRIQMRKSKIAIHYHQ
The following text describes a protein:
Function:
Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and of the fatty acid (FA) esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Preferentially hydrolyzes FA esters at the sn-3 position of the glycerol backbone in DAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity).
Subcellular Localization:
Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Lipid droplet. Note=Found in the high-density caveolae (By similarity). Translocates to the cytoplasm from the caveolae upon insulin stimulation (By similarity). Phosphorylation by AMPK reduces its translocation towards the lipid droplets.
Sequence:
MDLRTMTQSLVTLAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHHFDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRKSIFFRASHNLAELEAYLAALTQLRAMAYYAQRLLTINRPGVLFFEGDEGLTADFLQEYVTLHKGCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPRLTVTISPPLAHTGPAPVLARLISYDLREGQDSKVLNSLAKSEGPRLELRPRPHQAPRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPIFSIDYSLAPEAPFPRALEECFFAYCWAVKHCDLLGSTGERICLAGDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSKCVSAYSGTEAEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPQKTTSPTAESVRPTESMRRSVSEAALAQPEGLLGTDTLKKLTIKDLSNSEPSDSPEMSQSMETLGPSTPSDVNFFLRPGNSQEEAEAKDEVRPMDGVPRVRAAFPEGFHPRRSSQGVLHMPLYTSPIVKNPFMSPLLAPDSMLKTLPPVHLVACALDPMLDDSVMFARRLRDLGQPVTLKVVEDLPHGFLSLAALCRETRQATEFCVQRIRLILTPPAAPLN
The following text describes a protein:
Function:
Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation and promoting disaggregation of ADP-stimulated platelets in the host. Cleaves adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP) and inorganic phosphate. Interacts with fibrinogen receptor integrin alpha-IIb/beta-3 (ITGA2B/ITGB3).
Subcellular Localization:
Secreted.
Sequence:
MKSLIGTLGLYCLFILTNNVVSSYGDDLYPLTIMHTNDFHARFEETNVKGNPCKSGEKCIGGLARVLHTIKKIIKEQEKKNIESLYINAGDNFQGTIWYNIGRWNVTSELMNIQPPDVMVLGNHEFDHGIDGLLPFLNNMDKTEIVVANMDARDEPQVAKKIKPFTIIKKKYRNIGVIGVVVEEVPDLANTGKLKFRNESEAILEAARNLKKEDPSVNIIIVVSHVGFDVDKIIAERTGSEVDIIVGGHSHTVLYTGTPPGPEKPEDNYPYVYNHPSGNKVLVVQAVCHAKYVGNLTVFFDKKGKVVTYEGAPIYMDTKVEQDKDVLEAMKPWRKLIDEKTKLVVGRTNVDLPRDICRSEECALGNLYTDSMIYAFGGKENCKSGSTWTTAPIAFVHAGAMRSSLHQGDILYSDALLLSPFTNMVVAYDLPGAQLKAALEFSAAPKNEDEKRRFLQMSGLKVTYNMSRAANNRIVDLKVRTNVCPYDQYENLDEKKTYRVVSPSFLQGGGDGFKMLRDYAKNIQNQKIDLDALVDYLKKFSPLAPKAEGRITIIH
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MLSAFDLNYLLDEDLLNGEHIKKFFGECSGRRWLPNADTPLPSPIAGGAAIGGECCGGSGGGIPNAGTLSPYPSAAAATGTTVGGESGGGGSWVPLQVPYYQLQQQQLQLEQQSVGSVEAAAESGYPLQVPYNQLLQQQHHHQKEQEQQQNLEAFWACQLKEINETNNFKNNKLPLAHVKRLMKDNEDVCKVSEETPMLMAKVCEMFIQELTLRSWFNTEENKRRMVQKKDVAKVIEQTELFDFLVDIVHKDEIREEGAGFGASMLGSTSSDVQNAHPPMGQTAPSEVMIRGTASSGKFELFWMLWVNLRVLYCTN
The following text describes a protein:
Function:
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression.
Subcellular Localization:
Cytoplasm.
Sequence:
MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQDEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWTPPAEGEHSLEGEVHYSAEEAVKFIEDRITEESKSSRHLRGPHLAKLELIRRLRHQGFNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQQHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKSCLKTELQFSDYYCLLAVHVLIDIWRETGDETAVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAGSLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEALRDNRDLNVFFSWDPKDRDVSEEHKKLSLEEETLWLKIRSLTLRLISGLPSLNHPVEPKNSEKTTENGVSSRIDILRLLLQQLEVAMEMGKRFIEKEIQYPFLGPVPTRMAGFFNSGCSQCQTSSFYLVSDIYELDTNGLQDTTEIQERVENSLKSLLEQLKDVFSKCKGDLLEVKDGNLKTNPALLENLVFFVETISIILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGIQTLISNVVDHIKGLETHLIALKLEELILEDTSLSLEERKFSKTVQGKVQSSYLHSLLEIGELLKKRLETTKKLKI
The following text describes a protein:
Function:
Zinc chaperone that directly transfers zinc cofactor to target proteins, thereby activating them. Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.
Sequence:
MSEVANDNHAPIPVTVLTGFLGAGKTTLLKYLLQAEHGMKIAVIENEYSETPIDGQLLGVEPVQVMTLSNGCVCCSINTDLEKALFLLLERRDNGEIDFDRLVIECTGLADPAPVAQTFFADEELCQRYVLDGIITLVDAANAERHLQETIAQAQVGFADRILVSKTDLVDAATFEALGQRLQRINRRALVHVVEHGRIDLAHLLDVRGFNLNADLGPGIGLRPLRAVAAKDSRDRIGTLVLRSDTPLDLERLSEFMDDLLQWHGNSLLRYKGVLNIADEPRRLVFQGVLRLYGFDWDSEWRDDEARESVIVFIGDNLPEDSIREGFERIVEGR
The following text describes a protein:
Function:
DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
Subcellular Localization:
Chromosome, centromere. Chromosome, centromere, kinetochore. Chromosome. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.
Sequence:
MEASRRFPEAEALSPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVLSRIQKIQEALEELAEQGDDEFTDVCNSGLLLYRELHNQLFEHQKEGIAFLYSLYRDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVKEFIKWTPGMRVKTFHGPSKDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKSAICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPSLSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACCLLNLGTFSAQDGNEGEDSPDVDHIDQVTDDTLMEESGKMIFLMDLLKRLRDEGHQTLVFSQSRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQNSVTQLQLQSLHAAQRKSDIKLDEHIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLVEFESQNKEFLMEQQRTRNEGAWLREPVFPSSTKKKCPKLNKPQPQPSPLLSTHHTQEEDISSKMASVVIDDLPKEGEKQDLSSIKVNVTTLQDGKGTGSADSIATLPKGFGSVEELCTNSSLGMEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPEEVVVKAKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDISPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGSPQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLNNN
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
SKMILGYWNFRGMGEQIRLMLEYLGLEYEDVKYYQVLRKDNTADLSNWLDEKYKLGLNFPNLPYLIDKDVKLTESMAIMKYLANKGGLMPETEEEHIRCDIFQGFMIDFRKTFRDLCSNPDFNILKQKFQQNLDIKLRQIDTFFGCHEWMAGKRLTWIDFYFFETFDVIQMCFPESVDGHPRIKHHREIFLTLQPISEYRKSNRFIKYPVRGVRAVWGSARS
The following text describes a protein:
Function:
Endoribonuclease that initiates mRNA decay. Initiates the decay of all SAM-dependent riboswitches, such as yitJ riboswitch. Involved in processing of the gapA operon mRNA, it cleaves between cggR and gapA. Is also the decay-initiating endonuclease for rpsO mRNA. Involved in degradation of type I toxin-antitoxin system bsrG/SR4 RNAs and a minor role in degradation of type I toxin-antitoxin system bsrE/SR5 degradation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Dispersed along membrane with a few foci at septation sites and cell poles; in the absence of dynA fewer foci are seen, in the absence of minJ no foci are seen.
Domain:
Has 5 domains: N-terminal transmembrane, coiled-coil, KH, HD and an unnamed conserved C-terminal domain (residues 430-520). Both the N-terminal transmembrane helix and C-terminal domain are required for protein function in vivo.
Sequence:
MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQILEDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKHEGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIILERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQDGRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQNVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATKYKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEEISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVTVIRETRAVEYAK
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.
Sequence:
MSKSNCSDCTCRLANEVGQLKAIVNAQSRTLAKLVRQMKEGCKKDEEAKESTLCGLNPCLKCLQPDILYHLGLNTETTDFPKVFGDVRFVCMGGTPGRMENFAYYVMQEIGLKINAATKLRNISEAGQRFSLFKVGPVLCASHGMGCPSISILLHELIKMMYHAKCKDPVFIRIGTSGGIGVEPGTVIISSEAIDGRLNPVHEILVHGVSVQHASQLDESLADEIKMCHDPCKDKYEAVIGRTLCAHDFYEGQSRLDGAFCEYTPEMKKSYLETLQSQQVKNIEMESLAFAALTSRANIRGAVVCVAILNRLNGDQIKTPHDVLSKWEKRPQELVARYIRKVLYHNDDDDESEQPEDEAEAGAAGGGDTQKAPVEEAE
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Plays a role in nuclear envelope breakdown. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules. The recruitment of spdl-1 to kinetochores relieves this inhibition. Required for embryonic development.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore during nuclear envelope breakdown and remains there until the metaphase-anaphase transition. Localization of the RZZ complex to kinetochores is dependent upon knl-1.
Sequence:
MGRLGEAKAVDLEAETSTVGLYDVCTVGRILPLLNEMSIDKKSPAWKLKPKSNERFLVLASCSDLAVFSLGEKSDYSFNTGLGGAITDFEILGSSSFFVGVIEHRRIVILSLDKQEIYLNEPAPHEIDFVVCHTTSSVCQLIFGSRSDNWHTITLPGDVAASKETNRFENWHRDQIQEFFHQAMGKTVSKSVDMSKVAGDITLISNGPLQTFASIDQQRGIHWCGLVESEFEVIGMEKQFLQVRDGGRFSLHLDTDGWIHVFDSLVSSFCHEFDMKMSPDDKILDFVIIDKNEVEVPKMFAILVLPRDGDSTKMMIYDRLNKDNCFALDSSTSTTLFAYGGSDRVLIAVEELENSLADEQDGSQIVVRQVSQSRPEMRFESLLKNNRFEEAEKFAMAFMLDVQKVYKGHVHYLMDSCDESDESFETLMTKMGQIQDHNMVAETYFTLVGMSRRCDRIRTYLTHAKKRRITDLDILKMIEALCYTWGTYRIIAGPEENEPSRPQVNETIWDLFVEALHDANPWIEIYNEFISDAQFTQARVIFSRHGKSITDYMCDDEENTISRLETLFRMFIDAISSDISKWSNVIEHVTTDILPACVMITEELIPCLESLITSLISLLEYRDSTNWPENAIKAASSYDTMTKILSNNGNTPATQCILVMYGSKLGSSAGNKPSSMSRIKKIYYDLIELKRLKDVYECSISFSVFQNMSSEQICHKILQNALANPNMTHAKIEKFVKPFMAERHLDQEQTIVNYIQMMSGAAVTNANLFGWEKQCVQLCASLMDETRRCCSIISIASTAKIPWPAELNEAVEKILASRTLLRSEIEQMHLVCKRTELYKMLSSYGFSRQDIELLTTPDSNMDIILTIRCMLAHREKASRFVDVIKLVDLLKAMQGSSQPRTLRIEYVQSFAIIHMMSHQDVTISIINYIDSLGDRERVKTISLVFSFIECVANAPATGDNVLEREKILGVGEELMSHYTCRDNNFNDPERRLKDELVLLREVQKTETKAVLLSELKDEDWQRRFLERLIESNSSMSLNLGRCSYMGISPEHLIEMILTKATVENDMDTIVDSITNYVEFINSLTDSSREMLEPIVQILSWITFRLPKLLPNETEMARADYIAFVVKRIGRVVRETLRRFSFDVISDDLDYLLQLEAFYHLGEHIIKQSLRGQENENEKQEMFRSDDDTFLPTDSSNPFSNQSSLRIFEFKRPLGTFDFSNDPALFEGVQGVLALAMVAPSVARPYDSEISPDDANEFRSSWEQLNMFLAMHSQDLLDISARVFAGSLKCWAGEYLQGIVEMEQPILSVVERMLQQKKFDFWHAVTLLGGIPLERLDRAIIDLQKRQGVRSSTKATIQYLQLAFVMSLLARNMEKVPTIVSAYEQKYLVKKLAEEGIRVSITQDFVDKVLQQAIDLRQPLSPLRLHDYVKKYVEKLIRNSKISVGEYMVRYATLLIRKASVAGRHTDREIRKEEIEKYIEAARIALRIAEEEDASCICNYLHCLLYVVCPYNYEVIQFIVTSYGKYATETVEIEFNKNLKSIMAFLWAYQRTNHISNEESIWFTKRESVLMKDEKEFEKTGRMLDPFGHSLRVVYEDDGSNMSDSYNSDLALSSDAMVYERNSVIISDLPSLAEQYLPFHAFLLRKKEEIDEIVMGIVKAELSIFNVPIWQTFLREVSWLSSRFSRSQLLSSAIFAHANKYAKFGKSLPDGERNVIYELLNSASQRHVVVSTIALLFKRIILSDVKIELLQMGVNISERWTSDLTGEEQQEMEEQSARLKDGIAKFSTELELKKNGLYNEKTADNIENVSELCSLIYNEMVQWDDSRDVLKKCQVVDKIAKANGLDLTALHEQLVFSWVEDTQTIISINHVDMNESIGGTSFLDHKDETDDQNDLRIPLFDGILDKVVVLCQRIDKKRLLTRLGSILMRGGRKATGGYTAVVRATCIILRSFTDTEVSELLSGADMFALCSTLENQLYERLFEKAEVKGDCKTDKMQLIKSLLQCPSRTHPMTALIACLIIDHEFKDPKRDISLGWDVGCVPVSANSSNS
The following text describes a protein:
Function:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
Miscellaneous:
MISCELLANEOUS: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).
Sequence:
MSYNSIRLPQDLPIYYKNFFPVKPFTKWLRYGQNNGDYFNRREFAFILADDVHIRYRSYNDEHAFFKALSSTNPEKLDIGAVYNHEPINNKRHTDYQAVERELVFDIDLTDYDPVRNCCKDATVCPKCWKFMVLAVKILDFQLEDMFDFKARMWVFSGRRGVHCWVGDKKARMLNNYQRSAIATRLNLFKKNGQCEVTEGRAKMTKVPPIVRDAFNVALKDGVFEKMIYDQGWLDKEDFITEYKFMSEVGRDDLRSLSETYKTPQERWNMIRGLFDDDYRKSLSPKDGLLDFKMQGRDRNYLLYFVLQRCYPRLDVNVSTGTNHLLKSPFCIHPKTGNVAVPLNVGKIEEFDVSKCPRIDHVVEELSSLLAERGNDENEDSKNRKFLAYKHGALAPYVENFEKFVSACIS
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELARQTNKPGIFAERKEGVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSACKLEIETYEKDNCELCKKNIPFVKPGSREQK
The following text describes a protein:
Function:
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MEPAPQSSTFQPLSRREEDEFQKRIKLAALKQCDPVVAAFASCSSTRTISVAWACRKEWKAVQECMQIHMTEEKLDLARREYMTKREELRVPYKKLS