lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biosynthesis of BC325, a rapamycin analog containing a 3-hydroxybenzoate starter unit. Catalyzes the hydrolysis of chorismate via an intramolecular mechanism to yield 3-hydroxybenzoate (3HBA).
Sequence:
MNPSSLVLNGLTSYFENGRARVVPPVGRNILGVVNYASVCEYPTLDHGYPELEINMVAPTAEPFAEVWVTDAESEHGERDGITYAHDGEYFFCAGRVPPTGRYTEATRAAYVTMFELLEEFGYSSVFRMWNFIGDINRDNAEGMEVYRDFCRGRAEAFEQCRLEFDQFPAATGIGSRGGGIAFYLLACRSGGHVHIENPRQVPAYHYPKRYGPRAPRFARATYLPSRAADGVGGQVFVSGTASVLGHETAHEGDLVKQCRLALENIELVISGGNLAAHGISAGHGLTALRNIKVYVRRSEDVPAVREICREAFSPDADIVYLTVDVCRSDLLVEIEGVVM
The following text describes a protein:
Function:
Involved in the naphthalene upper catabolic pathway. Catalyzes the transformation of trans-O-hydroxybenzylidenepyruvate (THBPA) to salicylaldehyde and pyruvate. The reaction is reversible. Can also use substrate which carry trans-alpha,beta-unsaturated keto acid side chain and adjacent hydroxyl group such as trans-4-(3-hydroxy-2-thianaphthenyl)-2-oxo-but-3-enoate, trans-4-(3-hydroxy-2-benzofuranyl)-2-oxobut-3-enoate, and trans-4-(3-hydroxy-2-thienyl)-2-oxobut-3-enoate.
Sequence:
MLNKVIKTTRLTAEDINGAWTIMPTPSTPDASDWRSTNTVDLDETARIVEELIAAGVNGILSMGTFGECATLTWEEKRDYVSTVVETIRGRVPYFCGTTALNTREVIRQTRELIDIGANGTMLGVPMWVKMDLPTAVQFYRDVAGAVPEAAIAIYANPEAFKFDFPRPFWAEMSKIPQVVTAKYLGIGMLDLDLKLAPNIRFLPHEDDYYAAARINPERITAFWSSGAMCGPATAIMLRDEVERAKSTGDWIKAKAISDDMRAADSTLFPRGDFSEFSKYNIGLEKARMDAAGWLKAGPCRPPYNLVPEDYLVGAQKSGKAWAALHAKYSK
The following text describes a protein:
Function:
Probable kinase. Kinase activity may be involved in positioning of spindle poles in meiosis and mitosis. Plays a role in spindle positioning during asymmetric division of one-cell stage embryos. Affects spindle position by promoting microtubule assembly during anaphase. Plays a role in the assembly and stability of oocyte spindle, perhaps balancing the forces in the spindle and maintaining their morphology during metaphase. Plays a role in cell division and in embryonic viability up until gastrulation. Required for neuronal morphology and polarity and restricting ectopic process outgrowth; probably as a result of a role in maintaining microtubule integrity. Involved in maintaining neuronal microtubule number, length and packing. May promote axonal and synaptic growth. Plays a role in regulating thermotaxis responses in AFD thermosensory neurons. Required for touch sensitivity in adult touch response receptor neurons.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Enriched at microtubule asters throughout the cell cycle and is present on the spindle during mitosis.
Sequence:
MPQTSAWQLNDTTARPPPPPPPPGSEAGGSDGASMNGANTLPRVSKRVSAAGKTSNIPRFKRPHLPHSTRPLSAVLTSSSSPVVHRKISPSSSAPSTSSAHRRFSHLPQQHFHHHIHHNQTAVISEETLTTPRASTLNLNQTSVFPTAISQGSMPNSGTNTAEASMTSSVCAMETEGTNGDELAESRDMVSEMQRRCRIGPSGYPHLLKAKRLRFYRNGDQYFKGIQYALQSDRVKSMQPLMEDLMKTVICDSTALPHGIRHIFTIDGAQRITSVDQFEDGGGYVCSSTDAFKPVDYSRAAEPSWRLTLANRYNRHLETKKLALSVVEPCHENTDFVFPRIIKVIRNGVKPRRISRHLLNKKTARSFDQVLRDLTFVVKLDSGAIRKLFTLSGRPVLSLQDFFRDDDVFVAYGGNEKMAADDLLVASEEHKSVGSGTSSNMRRTSRRSTMPNRNESLRHDRSGSVIPDQDQQRLPPLLDEKFQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIGKEHLIEMELAILQKIDHTFIVQLYDHWFVDDSYYLSLELIEMGDLFEHLRIVRRVPERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGELGVKLADFGLAAEMPKDFGVLSTICGTPTYVAPEVLNKTGYGCKVDIWAAGVILYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSAGELLNDEWMVNLGDVDPEYEEWAHRFVQSKMHVEEEQETPYEYYTSRRTSMDELSESAAVEFSYSCES
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLIVLKTLQQQTFRVEIEDSATVRNLKDEIEKTQGKDFPASGQKLIYAGKILSDDNPLSSYNIDEKSFVVVMVTKRLQTEEKKEEKKEEAKPQETAAAASASASSAPVAMEEGTTKAAEEKKTEEKAAEPAAETKTQEESSSGLQAFHSAESTLVTGEEYQNMVTELMSLGFPRDKVIRAMQASYNNPNRAAEYLVVGIPDPPPETPGDQPPSQPSLQSSQSSSQPGGESSPSLEFLDQLPQFQQLREAISSDPAMLSQFLQSLGQSNPQLLQIISQRQEEFIALINQQPDAAAQPAVGGGGGGSGRGGSSSSSSLTSAAQPGGQQSSSQPANPPAQQAGGQGGGPGIRMSEENPGVAYIELMPEERDAIERLKGLGFPEELVIQAYFACDKNENLAANFLLHEN
The following text describes a protein:
Function:
Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.
Sequence:
MSSLASTSLRQASRLCLKQSTPPVGLVRGSAFARVASISNQKISRRGYVSETKRDSAQVNIDTAIRSEQKAFFKETGKHAEDQSISGTSANADAMMSPIAGVLKQATVMDEGQRPIYLDMQATTPLDPRVLDKMLPFYTGLYGNPHSRTHPYGWEADRAVEEAREHIAAVIGADPKEIIFTSGATESNNMSVKGVARFFGRAGKKKHIITTQTEHKCVLDSCRHLQDEGFDITYLPVQQNGLVDMAQLEAAIRPETALVSIMAVNNEIGVIQPLEEIGKLCRSKKVFFHTDGAQAVGKIPLDVNAMNIDLMSISSHKIYGPKGIGACYVRRRPRVRLEPIISGGGQERGLRSGTLAPALVVGFGEACRIANEEMDYDHTRVKKLSDRLLKGLLAMEHTTQNGDPDHFYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGSSDESAHSSIRFGIGRFTTEAEIDYVLQAVENRVTFLRELSPLWELVQEGIALDSIEWSQH
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSLVQSAERAEYLNLNTEQLKQLHEQSTRFLAGRHYNLSDDDRYALFEQHFYLALLVGDSREAEITYQKLADRFGEDTGRIGKLKSMLIDRQLGPKDALMYLQGRPESDLPCWKARIALLRDTGVADLYISELVKYLEVVPTDPEAWSELAEAYAACEKWGDAISAVEEVLLCAPLAYNMFARLGELYLAAGDAGEAISHFCRAVELCPVYIRAWCGILVAISKHKKGNDKLKAVATKQLEKLIKEKKGSEGDIAAAKLILA
The following text describes a protein:
Function:
Involved in bivalent formation and segregation of homologous chromosomes in meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MAPKSDNTEAIVLNFVNEQNKPLNTQNAADALQKFNLKKTAVQKALDSLADAGKITFKEYGKQKIYIARQDQFEIPNSEELAQMKEDNAKLQEQLQEKKKTISDVESEIKSLQSNLTLEEIQEKDAKLRKEVKEMEEKLVKLREGITLVRPEDKKAVEDMYADKINQWRKRKRMFRDIWDTVTENSPKDVKELKEELGIEYDEDVGLSFQAYADLIQHGKKRPRGQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MCELNNKRVSWSKTGLIAYADEQSTYGNLCISFLETINGVNCRFHPPQRYVIHPQLHEVPLKTETGNGINGASGSSTAQSNIHGTTSVPGSAGKHQHQFFYDISSIHWNNWFSLPGDMLAVCDELGNMTMLIAGQSPDGPTTLDKLTMLFQDNVYKIHNHVMQLEPERENTDSKLERKKTKKEYNTTILDFHWLSSSKPVIVSQFCAFDSSINMYRNKAQQLSPHGIFHPPFMKYAGLAIRRNGQLDFWYQFSNSKDHKKITLQLFNPHNERSKGLDFLQYAKITSVNNDNSILITTYSRLTGKLSFYKLFVDWNVNTAKPVVLNDPSLKIKHILDATVDQTDDEGRILDFTHVHVLAKVVAEKDAAPEVLLAYDVVGTPESLIKRFKLGQVRLPLDYLGILKPELNTSNENHNQALRSNRSNLRFLGVLNLHHKVASISSEVLDGFVSFYYRNGEIEIYNQNDWKLETERLLNQGPQGKFSNIITSILSAGFKYPTIKNLGTVEWIRVSPAMAGILYKYRHDDLPQFQPMNIDDVSDKSKDEINAATMAFGYVTSAHRQLSGEDIALACKQHILKIAKIDEKRAKDFTTTLMFNLYNFFNFSPGAPKELMDKIISSRPLQKVMLLQLELGSIFTDENTCEMARVILYLKNVSFAFNGVARNLQFAIEQMTNSTNSSNPPLSGDKFFQTAFSKQDLVHSLIPVTKWFVKFITYLIQQILILTNDPENPDNRLVLGVFGAKIPRTLILTILKEIKNVTAIITKFPETNYPILNESSTYLKMLLIESPINFEKFETFLMDVNNKLSAFSEQQPSIMREPTLLVRSSVPNELNKITEFLLQYSSNTVISHADASAIYFSDTSGLRISCDEFFEPGVHRLLQPIEDGIVIDEKNMPATFRDSKTFTKLTYDGITYDRFSKEELSDNKLKRCNRCGAVTKAGYPIPTNKTIVPTSISTRRWPTMYTRMCICLGMLYEL
The following text describes a protein:
Function:
Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylates the m3G cap on TLC1 telomerase which affects telomere silencing and telomere length regulation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGRTFIHASKIKHAARKRKHHSNFRTLIKLLNNDAYKIESSKPLKNGKLFKYWKNRRRLFSKIDSASIYMTDELWFSVTPERIACFLANFVKACMPNAERILDVFCGGGGNTIQFAMQFPYVYGVDYSIEHIYCTAKNAQSYGVDDRIWLKRGSWKKLVSKQKLSKIKYDCVFGSPPWGGPEYLRNDVYDLEQHLKPMGITKMLKSFLKLSPNVIMFLPRNSDLNQLSRATRKVLGPFAKCKVLYVKENGYMKGIFCMWGECFFNYEPASTENSRRESSEKEELSSENEELSKRKKHESTTTTKDNTVDIYDVNG
The following text describes a protein:
Function:
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane.
Miscellaneous:
MISCELLANEOUS: In many other E.coli strains this gene is part of a type II secretion system, but in MG1655 the locus is missing a number of genes.
Subcellular Localization:
Cell inner membrane; Lipid-anchor.
Sequence:
MNKKFKYKKSLLAAILSATLLAGCDGGGSGSSSDTPPVDSGTGSLPEVKPDPTPNPEPTPEPTPDPEPTPEPIPDPEPTPEPEPEPVPTKTGYLTLGGSQRVTGATCNGESSDGFTFKPGEDVTCVAGNTTIATFNTQSEAARSLRAVEKVSFSLEDAQELAGSDDKKSNAVSLVTSSNSCPANTEQVCLTFSSVIESKRFDSLYKQIDLAPEEFKKLVNEEVENNAATDKAPSTHTSPVVPVTTPGTKPDLNASFVSANAEQFYQYQPTEIILSEGRLVDSQGYGVAGVNYYTNSGRGVTGENGEFSFSWGETISFGIDTFELGSVRGNKSTIALTELGDEVRGANIDQLIHRYSTTGQNNTRVVPDDVRKVFAEYPNVINEIINLSLSNGATLGEGEQVVNLPNEFIEQFNTGQAKEIDTAICAKTDGCNEARWFSLTTRNVNDGQIQGVINKLWGVDTNYKSVSKFHVFHDSTNFYGSTGNARGQAVVNISNAAFPILMARNDKNYWLAFGEKRAWDKNELAYITEAPSLVEPENVTRDTATFNLPFISLGQVGEGKLMVIGNPHYNSILRCPNGYSWNGGVNKDGQCTLNSDPDDMKNFMENVLRYLSDDKWKPDAKASMTVGTNLDTVYFKRHGQVTGNSAAFDFHPDFAGISVEHLSSYGDLDPQEMPLLILNGFEYVTQVGNDPYAIPLRADTSKPKLTQQDVTDLIAYLNKGGSVLIMENVMSNLKEESASGFVRLLDAAGLSMALNKSVVNNDPQGYPNRVRQQRATGIWVYERYPAVDGALPYTIDSKTGEVKWKYQVENKPDDKPKLEVASWLEDVDGKQETRYAFIDEADHKTEDSLKAAKEKIFAAFPGLKECTNPAYHYEVNCLEYRPGTGVPVTGGMYVPQYTQLSLNADTAKAMVQAADLGTNIQRLYQHELYFRTNGRKGERLSSVDLERLYQNMSVWLWNDTSYRYEEGKNDELGFKTFTEFLNCYANDAYAGGTKCSADLKKSLVDNNMIYGDGSSKAGMMNPSYPLNYMEKPLTRLMLGRSWWDLNIKVDVEKYPGAVSEEGQNVTETISLYSNPTKWFAGNMQSTGLWAPAQKEVTIKSNANVPVTVTVALADDLTGREKHEVALNRPPRVTKTYSLDASGTVKFKVPYGGLIYIKGNSSTNESASFTFTGVVKAPFYKDGAWKNDLNSPAPLGELESDAFVYTTPKKNLNASNYTGGLEQFANDLDTFASSMNDFYGRDSEDGKHRMFTYKNLPGHKHRFTNDVQISIGDAHSGYPVMNSSFSPNSTTLPTTPLNDWLIWHEVGHNAAETPLTVPGATEVANNVLALYMQDRYLGKMNRVADDITVAPEYLEESNNQAWARGGAGDRLLMYAQLKEWAEKNFDIKKWYPDGTPLPEFYSEREGMKGWNLFQLMHRKARGDEVSNDKFGGKNYCAESNGNAADTLMLCASWVAQTDLSEFFKKWNPGANAYQLPGASEMSFEGGVSQSAYNTLASLDLPKPEQGPETINQVTEHKMSAE
The following text describes a protein:
Function:
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVLPLALTAFLNGITVNHLVALYSQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTDELYDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
The following text describes a protein:
Function:
Permease for malate and other C4 dicarboxylic acids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGELKEILKQRYHELLDWNVKAPHVPLSQRLKHFTWSWFACTMATGGVGLIIGSFPFRFYGLNTIGKIVYILQIFLFSLFGSCMLFRFIKYPSTIKDSWNHHLEKLFIATCLLSISTFIDMLAIYAYPDTGEWMVWVIRILYYIYVAVSFIYCVMAFFTIFNNHVYTIETASPAWILPIFPPMICGVIAGAVNSTQPAHQLKNMVIFGILFQGLGFWVYLLLFAVNVLRFFTVGLAKPQDRPGMFMFVGPPAFSGLALINIARGAMGSRPYIFVGANSSEYLGFVSTFMAIFIWGLAAWCYCLAMVSFLAGFFTRAPLKFACGWFAFIFPNVGFVNCTIEIGKMIDSKAFQMFGHIIGVILCIQWILLMYLMVRAFLVNDLCYPGKDEDAHPPPKPNTGVLNPTFPPEKAPASLEKVDTHVTSTGGESDPPSSEHESV
The following text describes a protein:
Function:
Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.
Subcellular Localization:
Golgi apparatus.
Sequence:
MYVRAAVLPLSAPRRAPCAPARGAPAAPRPGPRGSRCSPPRACCPPARGAPAAPRRAPAAPRSRGPRCFPPRSCCPPPARGAPAAPRRAPAAPPPPPRPAGPARTALLLPTPPACPARTAPAALAPSLPCRSIHIVALGNEGDAFHQDSRPSGLIRTYLGRSPLVSGDESSLLLSATSTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGSADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTSEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNSDLKEVAEAHKIVLCAVSHVFMLLFNVKSPADIQDSSIIRTTQDLFSINRDTAFPGASQDSPGNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEDDIRKKVKDSGDVSSVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKSIEIYGFIGWISSYIVFVVYLAWVFLPESAFHSLGIHYFPQKYWALAIPSFFVATIFTVITGYAALNYCFCNKLDSYENVEDKYTRLHNLKKTELHEGLPEVYDIPINVVNNVLYWQKEMVQKYMPKHND
The following text describes a protein:
Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGTRGSRIVGPRRGPIKAAPPGSRLHSEPSPVPSAGSSAGGGGLSSEAARSLPVSPCPRAVSMKAFSPVRSVRKNSLSDHGLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQSQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MDDSMMDDSVFSDGGSENFEPPAKPAKVTKAKAPPKKAAAPAKPRGRPAGATAKPKAKAPPKKKKVVSDEENSDIDMAEDPLDDDESLLQDTPPKQKKAPAPKKTSGKPLADIDNESFDAAAVKKASSGASSKYQMLTHLEHIMKRPDTYIGSVERQTDKMWVYNSTTESMEYRDVSYVPGLYKIFDEILVNAADNKQNDKNMSEIRVTVDRESGEVSILNDGKGIPIEVHAEHGIYVPEMIFGHLLTSSNYDDNQQKVTGGRNGYGAKLCNVFSKEFTVETVDSKQKKKYRQTWTENMSVMGKAKITDFKSGDDYTKISWKADYKRFGMDGIDDDFEALIKRRTYDMAGTLRGIKVYLNKERVKVTSFAKYMEMYTKAIAREQGNNEDDKQKDVIITDKHDRWDIGFAVSDGSFNQVSFVNSIATTSGGTHVNYISDQIVEKLMAVMKKNKAAVKLKPAQIKNHIFLFVNCSIVNPAFTSQTKEQLTTKASQFGSKPVLTDKFLKAIEKTEVIQNIMHFAQQTADKMLKKTDGNKRNRINNAKLTDANKAGTKDGHLCTLILTEGESASVLALAGRAVVNQDLFGVFPLRGKLLNVRDASVDQILKNQEIQNIKKFMGLQHKKDYTVADMKGLRYGHLMIMTDQDHDGSHIKGLLINFLQCQFPSLLRIPGFLLEFITPIVKVWKGDPKHPRSLKSFFSMPEYEEWKEQHKLEKGWDHKYFKGLGTSDIPDAQVYFKDLDTHMKRFQVMRAEEEKLIELAFSKKKADARKEWLGNFVPGNHLDLTTPEISYDDFVNKEFILFSIADNLRSIPSVMDGLKPGQRKVLYTCFRRNIKKDVKVVELAGSVSGSTDYAHGEASMQGTIVGLAQNFVGSNNINYLEPSGNFGSRLRGGADAASARYIYTRLSPFARRLFHAHDDALLKYGESDGHKIEPEMFIPVLPTILVNGSSGIGTGWSSEIPNFNPMDIIDNIRIRLQDGASKEDMKPMTPWYKGFTGTTETLAADRFQFTGTIRQTGENELEVTELPVRYWTQDFKEKLEDIIKAEKTPAFIKDYIDYNTPDRVHFIIKMEDKHMLNAVQKGLEETFKLYSKQSTSNLVAFDAQGRIHKYASVLDIMEEFYHVRLRYYEKRKQHQLEVMEKELSRMNNQARFIQMIIEGKLVVSKKKKAVLVAELRKLNFTPFSKAEDAKKAGETEDVQEEDEDEETELEISASDYDYLLGMAIWSLTQERVEKLRKQIGDKEEEVDTLIKLSPKDIWNVDLDAFVDEWNLQLEEDVKRKKKIAGITRRASKKLGIDGAKGKKKKRKAGDTDSDDDSGSDFGPAKKKAKPKKEGLLSYLRQEEPVKKPNAAAALKSSTAFGSTAPPKQGTLLTHLVKKESTPQVDGASDDPPAEEEDAPVTKRARPAAAKITKNAPVVVSDDDSDVFAAVAKEIEKKKPVAAARGGRGATKQMPKYNIDNSDSDSDDGDLLGDVSTMVKTIGAAGSNGVPLFKATSAARPVSNGSARPASAAGGAKAAKRNSPIEIDDDTTNYEGLVPQPSPKRPAPRNVHDTIMSSDDDSDVVIKKPAPKLTAKPKLAAPKAAAKPKASSTLVAKKSTALSPAAKAYAAKLAKTTGALSKPAAKAKKPVAVESDDDMEDADAIANDLLSDEDEDEPTPKPAARAPAARPGRRAAAAPAKYVVSDDEMDSDEASEPSFEDDESD
The following text describes a protein:
Function:
Catalytically inactive DNA methyltransferase that acts as regulatory factor for DRM2-mediated DNA methylation. Required for maintenance of non-CpG DNA methylation. Required for normal establishment and maintenance of RNA-directed DNA methylation (RdDM) and accumulation of specific repeat-associated small interfering RNAs (siRNAs). Required for nucleolus organizer region (NOR) nuclear organization during interphase. Acts downstream of the production of siRNAs. May promote RNA polymerase V (Pol V) transcriptional elongation or assist in the stabilization of Pol V transcripts.
Subcellular Localization:
Nucleus. Note=Colocalizes with AGO4 in perinucleolar region.
Sequence:
MADMRRRNGSGGSSNHERNEQILFPKPETLDFDLPCDTSFPQQIGDNAASSSGSNVKSLLIEMGFCPTLVQKAIDENGQDDFELLLEILTKSTETEPPGPSFHGLMEPKPEPDIEYETDRIRIALLTMKFPENLVDFALDRLGKDTPIDEMVDFIVAAQLAEKYAEESEDSLDGAEINEEDEDVTPVTARGPEVPNEQLFETMDKTLRLLEMGFSNDEISMAIEKIGTKGQISVLAESIVTGEFPAECHDDLEDIEKKVSAAAPAVNRTCLSKSWRFVGVGAQKEDGGGGSSSGTANIKPDPGIESFPFPATDNVGETSRGKRPKDEDENAYPEEYTGYDDRGKRLRPEDMGDSSSFMETPWMQDEWKDNTYEFPSVMQPRLSQSLGPKVARRPYFFYGQLGELSPSWWSKISGFLFGIHPEHVDTRLCSALRRTEGYLHNLPTVNRFNTLPNPRLTIQDAMPHMRSWWPQWDIRKHFNSGTCSNMKDATLLCERIGRRIAECKGKPTQQDQTLILRHCHTSNLIWIAPNILSPLEPEHLECIMGYPMNHTNIGGGRLAERLKLFDYCFQTDTLGYHLSVLKSMFPQGLTVLSLFSGIGGAEIALDRLGIHLKGVVSVESCGLSRNILKRWWQTSGQTGELVQIEEIKSLTAKRLETLMQRFGGFDFVICQNPSTPLDLSKEISNSEACEFDYTLFNEFARVTKRVRDMM
The following text describes a protein:
Function:
Involved in the perception of CLV3 and CLV3-like peptides, that act as extracellular signals regulating meristems maintenance.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRSKAKGLVRPLITKPVQPLSSHMHLFLLCILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPLNWNLSIDCCSWEGITCDDSSDSHVTVISLPSRGLSGTLASSVQNIHRLSRLDLSYNRLSGPLPPGFFSTLDQLMILNLSYNSFNGELPLEQAFGNESNRFFSIQTLDLSSNLLEGEILRSSVYLQGTINLISFNVSNNSFTGPIPSFMCRSSPQLSKLDFSYNDFSGHISQELGRCLRLTVLQAGFNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVKLNLRVNQLGGGLTELEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFMGLSDNKLTNITGALSILQGCRKLSTLILAKNFYDETVPSKEDFLSPDGFPKLRIFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGELPKELFQLRALMSQKITENNYLELPIFLNPNNVTTNQQYNKLYSFPPTIYIRRNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYFNVANNSLEGPIPSEGQFDTFPKANFEGNPLLCGGVLLTSCKPTRAKENDELNRTFLMGIAIGYFLSFVSILVVRAW
The following text describes a protein:
Function:
Transcription factor which may be involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MNQEGASHSPSSTSTEPVRARWSPKPEQILILESIFNSGTVNPPKDETVRIRKMLEKFGAVGDANVFYWFQNRRSRSRRRHRQLLAATTAAATSIGAEDHQHMTAMSMHQYPCSNNEIDLGFGSCSNLSANYFLNGSSSSQIPSFFLGLSSSSGGCENNNGMENLFKMYGHESDHNHQQQHHSSNAASVLNPSDQNSNSQYEQEGFMTVFINGVPMEVTKGAIDMKTMFGDDSVLLHSSGLPLPTDEFGFLMHSLQHGQTYFLVPRQT
The following text describes a protein:
Function:
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Subcellular Localization:
Cytoplasm.
Sequence:
MDISYHEKISKTYELIKKSTYSVAFTGAGISTESGIPDFRSPNGLWQRFRIVTYQEFIIDRKARNEFWKMKRELIQEIINAKPNNAHNALAELEKRGLLKYVITQNIDGLHQMAGNKSVIELHGNQRGYICLDCEKVYPLEEVLKMLKEQELDLRCEVCGGIIKPTIVFFGEPMPEKELLMAQQIANKCDIMFVIGTSLQVEPAASIPRIAYQNGAKLIFINKVQTEWDWIAEIIFYDSAGKVLKDILDVIKSEKF
The following text describes a protein:
Function:
Required for survival during stationary phase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MICYFLVVTINFLKEKTTICHYFVNIFSLFLFLFVFVFVFIFVYFFYVILFYRFCSLFTYFPANSIWYYLSIINIFFPLCFFLYENFTGRNRRKCSLFCLTLIKITYTSPNHGFMVTGKEKFEKLRD
The following text describes a protein:
Function:
May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).
Sequence:
MNDEGDLLQENTRDEGNETEASRMSKLRRTRKKVTKQHIFSTEVGEMDVSNSKERIRSQMVCHTLGNMSKPVVGPGSADSHLPQDDKDSENQTTVIKPSPLKTSASAPCSEFNTNSNHADNTWEDTQIPTTPHLSSRMKHIKQEMAKNHLQFVRFEATDLHGVSRSKSIPAHFFQEKVIHGVCMPRGYLELIPNPKDDEVDHIRATCFNSDIVLMPELSTFRVLPWAERTARVICDTFTVTGEPLLTSPRYIAKRQLSQLQDSGFSLLSAFIYDFCIFAVPEIINSKTISFPASTLLNNHDQPFIQELVDGLYHTGANVESFSSSTRPGQMEICFLPEFGISSADNAFTLRTGVKEVARKYNYIASFFIETGFCNSGILSHSLWDVDGKKNMFCSSSGIEELTITGKKWLAGLLKHSAALSCLMAPAVSCRKRYSKESKDLKESVPTTWGYNDNSCAFNIKCHGEKGTRIENKLGSATANPYLVLAATVAAGLDGLQSSDGVLASPGDSTDLYPSKPSEIPLKLEDALVALEEDQCLRQALGETFIRYFVAMKKYDLENEETDAERNKFLEYFI
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MSSDLEQTNNPPMRGIPAITGPIDYTKAFHVFPKELQPFRNSIIAYGASLFSTLVGFPLDTVKTRMQTHKNFTSYFDCVKKTYAKEGVRGFFRGIWAPIISTSLSKSLSVSLFTTVKPYTYGLLYETPWTKNIESSHPFLRNIPVCFISGLIAGGGVSLFACPFEFTKVYAQLEKLVASKSLKELSNLNNNGGTSSAQLTTKFNSVKTPSTAVIVKEILKYEGIKGLYSGYKYHLMRDSISTGFYYSIYESMKWSINNFINKDPSISSPFSVLLAGGMSGVFSWVLIFPIDTTKSMVQKDAVTNILRRSHGLEPLPPKHRKLQKFEKRAYRGLGISVTRSFIVNMVFFGVFELGMTYLA
The following text describes a protein:
Function:
Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (By similarity). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (By similarity). Can completely deacylate triacylglycerols (By similarity). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity). Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency (By similarity). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
Subcellular Localization:
Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection. Note=Localizes to neurite tips in neuronal cells.
Sequence:
MMLFVWTTGLLLLATARGNEVCYSHLGCFSDEKPWAGTLQRPVKSLPASPESINTRFLLYTNENPNNYQLITATDPATIKASNFNLHRKTRFVIHGFIDNGEKDWLTDICKRMFQVEKVNCICVDWQGGSLAIYSQAVQNIRVVGAEVAYLVQVLSDQLGYKPGNVHMIGHSLGAHTAAEAGRRLKGLVGRITGLDPAEPCFQDTPEEVRLDPSDAMFVDVIHTDIAPIIPSFGFGMSQKVGHMDFFPNGGKEMPGCEKNIISTIVDVNGFLEGITSLAACNHMRSYQYYSSSILNPDGFLGYPCASYEEFQKDGCFPCPAEGCPKMGHYADQFQGKANGVEKTYFLNTGDSDNFPRWRYKVSVTLSGEKELSGDIKIALFGRNGNSKQYEIFKGSLKPDARYTHDIDVDLNVGEIQKVKFLWHNNGINLLQPKLGASQITVQSGEYGTKYNFCSSNTVQEDVLQSLSPC