lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MKLTQEIKFSLQKTQKVLSIQMQVHHINDFTKLFKKCIFPGSRWQLEQENIKSIATTFEEPLPENLQEFIKENNCQILEKEVTVGYDNMTYNEVLQQLLPKNVQAPQGYEIIGKIAHFNLSLEQLPYKYLIGQVLLDKNKHLQTVCNKLEKLHNVYRTPQLELLAGNNSYDAIVPEGGVRLFLNFEKVYWCTRLYSERERVIKYIKELSNGKNIKVLDLFCGIGPFSLRIAKDLNAQCLANDLNPECYYYLLKNIIENKVQNQVTPLNMDAREVVLKIYNKEIDFDFNHVYMNLPVLAINFLDVFKGFTQRTGKVDLPYIHVYGFAKGKDDQELIEQFSQRIIKGLPGFDKSQILRFHILKNVTKMKKMCCLSFQLDKKSAESEFGLVEQEDGNNSDFEDDEKMEQHELVEDVVNKKVKID
The following text describes a protein:
Function:
Acts as a component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex.
Miscellaneous:
MISCELLANEOUS: Present with 476 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSTTTDSLPTPENSAAENNDEEEGQNSEAGTYRRSVLQQKKRRRERHWRSVVGEIYSTTESETDSQEEETEEGGEHDTGIDKEDSDEERKFWKKYEKPEKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHCTKENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLAYKIFATLIRIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKSRFVQNINYRSIVPPFQTGSRTHTAKFAITYLWSSLINCQKSMEPSSNIIDKPFDTENDLLQELIDKISEWVLTPPFMEDAEVWFIYASCHLLKADTLSRQFVNDNKNNDLIGLDRDIKINQVIKHIHYVRTFLKICLDKGGFAVPSRLIENQLKSFESRLYGEAQDIQERDVANVYDSIDNSSVENSFGDVYETNAEFLDTQLMDLSPEDNGLDEMHYSDEDSSE
The following text describes a protein:
Function:
Transcription factor. Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factors unc-3 or irx-1 in subsets of motor neurons. Probably acts by binding to specific promoter elements. Required for ventral D (VD) motor neurons to adopt their normal synaptic pattern. Suppresses expression of flp-13 in VD motor neurons to ensure formation of the correct synaptic pattern. Maintains low cAMP levels in VD motor neurons by enhancing expression of pde-4 which hydrolyzes cAMP and repressing expression of acy-1 which catalyzes cAMP formation. This prevents respecification of synapses by VD neurons. During copulation, required in males for correct movement of the spicules, a pair of prong-like structures which are inserted into the vulva of the hermaphrodite and anchor the male to the hermaphrodite. Required for spicule prodding which allows detection of the vulva location and for spicule insertion into the vulva; [Isoform a]: Required for normal locomotion.
Subcellular Localization:
Nucleus.
Sequence:
MQDGSSGAASLGNSSPDATDCVVCGDKSSGKHYGQFSCEGCKSFFKRSIRRSLSYTCRATKNCAIDVQHRNQCQYCRLTKCIRMGMRKEGRRSNETQTAVSAVQRGRLPVTMPSLFPPNMFLRSPFPFMSVPFNPLMTAQFTKPSIKESIFEFAAQTIFATVNWARTSMSNLVKGDQLILLRHSWTPIFIFALAQSNFALNLSTHLTAVTATAASTENGSSSLGSKSEDEEKSEEKPERVFDEPQFQGFQAKIDKIRDFHLDVVESSSLRAVLLFSCDEEALEEKGKIEEIVEKLKSAVDEYCKMNKRSERYHQICECLQLLKSTRNLPISRLFFSRLLGTTPLETILSDLLITPPPPTLPFFPQLPSRN
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MTKPQGTGGKKKNQLTLAQLAAYDDILTDALVDHAYYWTTIPKNRTSYHPSRGIKEEEITKIIQNHLIVDPDIATAEEKLLATDGLKRFCNTLKTPREQNDFKAHLRRYMSIYLPDCPFEVNATNRYTIVTYEASITARRFIQRNETIKYLAGIQVVITPEEELEMSLRKKDFSLIVSSRSKSTSLFMGPARFANHDCNANARLITRGQAGIEIIACRNIEVGEEITVTYSESYFGENNCDCLCATCESNLRNGWRPVDGEAAVQKSIEDEQPTESSTPYSFRRKRRYGSTALQASRTPSVTPDMRPRVLRKSQSQMMLGERTSTTDSAAQGAGADGQSRKRALEMGTPPFTPTKKQKTTQYPVVPIALSTAPSRGSSDNETSKSPLSFSTTNDNVTDATSQGSESPGPIILSPEPTPIKQAIGLLKQEEGVNEVAVQQVPEAFTPPPSQPTEEEPPMVRPAFERLAARDRMSIANLISGPSSPAPPVVFSVAEVTTHRPKPQTLQLQKTDQTATISTLQTVTAAVQKEAPVVKTESPIKPTVGQVEKITQVQTTTKSCTPSKPKAQAAALPQHHMPVSTAPRGRVPHDYTLTPLLLSEPETAWIMCTHCASAFVQKNAYLTKSTCPRCERHSKLYGYMWPKTEKYGPNDKEERILDHRMINRFLTAEEEARARGRVYWRERMGSKGKQGSSAPSTKGTPAGEKNEQSAKQEQSQGQYVQERFAVRKKVKVQVRSTVPTPVIMTKKDEVAEAAALGLRRSGRARRVSAKLADCELDF
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (Probable). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (By similarity). Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Sequence:
MITIFWIWGICLSVCCCLWLILGLRRRRMGEPPLEKGWIPYLGCALQFGANPLDFLRANQRKYGHVFTCKLMGKYVHFITNSLSYHKVLCHGKYFDWKKFHFTTSAKAFGHRSIDPRDGNTTENINNTFNKTLQGDALISLTDAMMENLQLTLRRPEPKSRAWVTEGMYSFCYRVMFEAGYLTLFGRELTRQDAQRAFILNSLEDFKQFDKVFPALVAGLPIHIFMTAHNAREKLAEGLKHDNLRTRDHISELIRLRMFLNDTLSTFDAMEKAKTHLAILWASQANTIPATFWSLFHMMRSSEALKAATEEVNKALEDADQQINFEGKPIHLNQTQLNDMPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPMTFKYDRYLDENRKTKTTFYSKGLKLKYYYMPFGSGATICPGRLFAIQEIKQFLILMLSYFELEFVDSHVKCPPLDQSRAGLGILPPLNDIEFKYKFKHL
The following text describes a protein:
Function:
Positive regulator of FPS1 glycerol channel required for the glycerol efflux.
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium; MISCELLANEOUS: Does not bind efficiently to phosphoinositides and does not associate with membranes.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDYFTFPKQENGGISKQPATPGSTRSSSRNLELPKNYRSFGGSSDELASMYSADSQYLMDMIPDSLTLKNEPASGNTQMNGPDGKENKDIKLDEYILPKTDPRSPYYINMPIPKKLPKSEGKARAKQKVNRADPSDLDVENIYETSGEFVREYPTDILIDRFHKWKKILKSLIAYFREAAYSQEQIARINYQMKNAVKFAFLTDLEDETNKLVDPSISKLPTKKPQPVPLAAQKLDSKYDTDVEQPQSIQSVPSEEVASASSGFMKFGSGSIQDIQVILKKYHLSLGSQQYKISKEILAYIIPKLTDLRKDLTTKMKEIKELNGDFKTNIGEHIKITSRLLNKYIASVKLLDEASTSGDKQGEKLKPKHDPYLLKLQLDLQLKRQLLEENYLREAFLNLQSAALQLEKIVYSKIQSALQRYSALIDSEARLMIKNLCHELQQGILSRPPAVEWDNFVSHHPTCLMNLKSTDPPPQPRRLSDIVYPNMKSPLAKCIRVGYLLKKTESSKSFTKGYFVLTTNYLHEFKSSDFFLDSKSPRSKNKPVVEQSDISRVNKDGTNAGSHPSSKGTQDPKLTKRRKGLSSSNLYPISSLSLNDCSLKDSTDSTFVLQGYASYHSPEDTCTKESSTTSDLACPTKTLASNKGKHQRTPSALSMVSVPKFLKSSSVPKEQKKAKEEANINKKSICEKRVEWTFKIFSASLEPTPEESKNFKKWVQDIKALTSFNSTQERSNFIEEKILKSRNHNNGKSSQRSKNSTYITPVDSFVNLSEKVTPSSSVTTLNTRKRANRPRYIDIPKSANMNAGAMNSVYRSKVNTPAIDENGNLAIVGETKNSAPQNGMSYTIRTPCKSPYSPYTGEGMLYNRSADNLMASSSRKASAPGEVPQIAVSNHGDEAIIPASAYSDSSHKSSRASSVASIHNQRVDFYPSPLMNLPGVSPSCLALDGNANGYFGIPLNCNSEARRGSDLSPFEMESPLFEENRTQNCSGSRKSSACHIPHQCGPRKEGNDSRLIYGNEKGASQSRLTLKEPLTSKGVEAPYSSLKKTYSAENVPLTSTVSNDKSLHSRKEGSTNTVPATSASSK
The following text describes a protein:
Function:
Small GTPase-like component of the intraflagellar transport (IFT) complex B required for both anterograde and retrograde intraflagellar transport. May be involved in cargo loading of the retrograde transport.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MVNLRLQVAVVGAPTVGKTAFVQMLHSNGTTFPKNYLMTLGCDFIVKEVPVDDDNTVEMIIFDVSGQREYEPMVSSYLQNTAVFIVMYDVSNKVTFEACARWVNQVRTNSKESVGILIANKSDLSDKAEVTDRQGKDLANANKMKFYKISTLRGVGITEPIDEIARHYVDAYQKRIEQLTQMR
The following text describes a protein:
Function:
Required for peroxisome inheritance. Acts as the peroxisome-specific receptor for the myosin V motor MYO2.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MTTNSRPSALQAPGLQIFSMLKSSEEDGFMSSSLTLDSDNIIGVTENNRQEFYSTWRKPSLLSSRSVLHEYSPTIVGSNDCTFSPITVGKTTKFFNWDDIISRIFMQQPFGVTHQFFEEFRYSIITSHFLNDMNHYRLSLHLDQSIMNFHKSSTLLKNVPPKSVPFMATKYGKLAVAEDKKLYFRQNFNYLSMIITSYRVLTQLKKYCRKKNSPGLKRVVILILVAVYLSIQQEYFRRHLICYKTLLKVRKVLESLQQVDVMIHKYHLRFKEIKNHSFISRVSLISIADEHSSVIKELLVFSSDALFYKLKSIIPDIVIFSDTSELSKYCELYGIDVPNLYYNNTTTVKDLDGKLYRLKLLKKFMLCCLLSLDMTGNENLSNVNMRNALNKIFPDYMARVQLKKKYNPIGTFQNIVSLLRGLHSLLSTVLVSLNDHKQILYAFPEETSTNTGCERANVCSFSKNDKLFQALNYLKMIENNLLAIDIRNGITENDRNIIEDKLEELITFWKTSKICGNISRIQKVSPTNTINHGFHLDILKGRKSPRSSSVQGLSLERKVDFIDVAESVNDSFENDTELEEYEDYDCQEECSAGSRQNHRVDFIGKDSCRKPDFKQLSDNELRRKLDERILKLAQENREGRERLRTAKSFELLRKAQASMSVKFGFQKPLRDDAFLESRPLSKCKVSSEETIPFLYELKGLLGNDS
The following text describes a protein:
Function:
Required for preprotein translocation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTENVPQGQITMPLQQGGAREISPQALAVADYLRSHKLLKQRPGILNGKRSDFFRVKRAIRALEDPKYKQLQSKPNSKLPPINSRNEAISIFRLMPINQMALRVDKLPTQTALMMKQKPEQGVPVLQVNPQQEFGDDMYYTWFYNPVPLTTYLYGALGVAAIFAGVLFPLWPIFLRQGVWYLSVGMLGLIGVFFGIALVRLVIFVLTWPTVKPGIWIFPNLFADVGFVDSFIPLWAWHGTPERDLLPQKFKNKKKKKNAGTVIESKEPPRKLTKEEKQKQKEANAQMEQMQAAFQTQLSSFATQMQQIKEMSDSGIDPQIIAAQLQAQYPPDKQAAIKLENEQAQAKLDERIRELAAQIQDKTNANKTGDKIEEVADKENKEAPKRIVTLEDANDE
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MKLSACAVSAFLALLLWVHSSTGQTDRAPPCMRPQHRVVHTVQIVGSRLPDCSHACGSCSPCKLVSVGSTCARARPNRAESCPISYRCMCRNKLYPVP
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLESALSIARQYAQSSLAQLPESAQNALLNPLVQKALTAALVYGALRQTNRLLSQWSINNWQRAHPWQGDRELVLVSGGCSGIGKQIMEDLSRKGIRVVILDINEPNFQLPRNVHFFKADITNSESIRAVAEKIRQKLGDPTVLVNNAGVGYDGTILDEPEAKIRQTFEVNTISHFLMVREFLPSMIRQNHGHVITIASMASFVALGEMVDYCCTKASALAFHEGLTQELRYWYQARKVRTSVIHPLWVRTPMIQQLTDAGNQFKQPVMTPQVVSDAVVKQILTQSSGQVILPTSHSAASMVRAFPQWLQETVRGIASGSLRRLREHQAAQKL
The following text describes a protein:
Function:
Plays a role in microneme replenishment, probably at the vesicular trafficking level. Directs microneme organelle traffic differentially based on microneme population. Regulates microneme secretion: facilitates microneme membrane fusion with the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Overexpression causes parasite lethality.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Endosome membrane; Single-pass membrane protein. Cytoplasm. Note=In intracellular parasites localizes to the trans-Golgi-endosome network; upon egress disperses into the cytoplasm. In extracellular parasites, localizes throughout the cytoplasm.
Sequence:
MAAKAIQYNIKVDLHEVKDLSFREAAGEKEIVPNPYIEVTVNGVTKTTIQKTQVVSATFNTSFNFTAYLTPDEFARSYVEVAVLHKYMLIGGVGLQSAVIGKYVFSFAYVYTKSQHWIYRQWVTLRNLDQPQDETGLLLITVGVFGPGDAMPVVDETVCVVNEGERTSTDVNVKLTHYSLSVNIFKGQDIPSVAGQFSTVLEPYVKVKHGGAELQTRPLPDSNPDWLASISIPACVPCFDGNVLVELWNGQDSSTAAGTLMGTVVLDYFQLIKNDLPPRWFNFYWRPPAEGLLGAVTDMMASAELREPIAYGGRILLSASAAKVQTPLPLGVRSARPIPDPATQECVWWLDLYEMTSATGYTSELRIEIAFGPHVIKTASLEANALGTYVIGDNLGRLPEMKIFAPVDEVQVWDVMMYVCSPPATTVAAGIADISNWFSGWGGSPTATQNTPEPAETPWTRLAWVRIPYDSRQFQNGKPQWYSLRSLDGSGTDMFSVLLGMEMFPTKAGKQRAPRLEYKLARFYFRALIYEGLHLPAVGYDVFPDPYIQVELASKTLRTSTIRQTLNPSYYEAYEIEIRLPENISLAPDINVEVISESNSLLSSDVVLGSVQYPIQKVPKEWTKAPVWLQLHSKAYPRCKARVLVAFELVPAEKAEDDTYPFYDDIRPSTKEGNIRLFLVGVRLFKPITQPFVTVCFGRDVENTAEPLWSQESSAPRTGEGGNWNFLEEFTVSVSLPKRMQHHSFLEVKIQDRTQGIGGESNVDVGMAYITLNPLLPWLDSRERAESLETFRLQMLEEVLIEDAENARRSADGGLAARTGGGSFDEDATKKKEMLAAERSRKMAIPYNDPDMANLKIEEVDDYVSFKVAPRPQASRLSREGTSRDERGKAPGKSLSGMPGPVARASPGAGEETEKKGDPVAEKKEGGAQAAPPVAPSAHQREALAASPEEETYGFTPEQLNFVLADLEEDDAEEMTRDEVPYELEADFTVDDLPYLRTPIFRPTDAGVPETVGYLKYVCRVFQSTDEDEGAEMDAVCKSLIETYNSTRDLVVRAYVLAARGLVPPSGASDIQTYVWIQDSENAATLPGGLSYNIRDTGYTKKQGFKPEFNRCYTLACSLPENSIVQIAVMNMGRLTDECIGRTYLDVEDRFFNKKVEQMVIEESTPIELRTLKNEGSTVSHGSLRGFFEIMRADYAQLHPPYTLASAEPDEYQLRVVIWRVKAVPLDDNSSISLFVRTIYQLEDSSEIVKDTDTHYNSTDGTAVYNWRMVFDVLIPAQIPVLKLQIWNYALLSSTEPIGEANFDLTADFFRARKRQQHYRVPRMWVRCSHPAHKGKLRGTIEIEASILPREEAEYTPVGNGRDEPNRDPFLPAVTTNRTYIDWQQIGETVGAASSAIMSGLKWTGVWMTVAGIIALVIFVMFLLK
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MLSHALVQRDSNCDLDSYAWCRTTDFTGNFLIGQAFAYMVEINSRDERQEARLIEILNFRDNLEHGGTFLVERGIPYAISQEVVPILRLEKLQKYPVPLDLIFKLNYLIQHGKLNATNFDDECAKLVIRGAEGHVRTALETISELPPQHDILNSRTLLISALEDAKLQFPNPPDLIAPSQGRAWIYRLLITPTKAYCMEPEVESCNRMIRLYEKHAENFLRVNFVDEDLCPLNGTSLVSAVNTSYSPLYRRIRKVLKEGFSIGNKRYEFLAFSASQLREGQIWMFAEVMMNGKPHITADTLRADMGDFSQIRNVAKCAARMGQCFSSSRKSLSVLPLQLKKIQDIFVTTDDVKYCFSDGIGKISADFARKVAATCGCGPGKVPSAFQIRYGGYKGVVAIDPDASNSFKLYLRPSMRKFDSAHFGVEVLEWTHVMPCYLNRQAISLLSTLGVEDRVFMNLQDQIVLKWCKAVNDETLATKLLMETASNSMALKLLSSGFTYESELLLRRLMLAYMHAQFNDIRTRARIFVPEGRMLIGCLDETGILEYGQAFVKISSNAEEIKSKTVSTVRVIQEEIIVLKNPCLHPGDVRVLQCVNVPQLQHMVDCIVFPRRGQRPHPNECSGSDLDGDMYLVSWDQSLLPPEVDAPMNYESPPAVILNRRVTIEDIQKFFVDYLVNDNLGYISNAHVVHCDREPEKARSPKCLELAQLASIAVDFPKTGVPAIIPYYLRPKEYPDFMEKEHKATYVSQGVLGKLYRATNDFPKPAEENFLESTRLTENSEPLRFCDPDLVIREHGPFVEQALNLKYRYDAKLMKLMNQYGIKDEMEILGGHIVSLSTVYKRRQKETTQKILLAFERLQKEARFWFHQFKEWKKLGLDKSVWVSAWYVATYHSDYYGRHKLQYSEVTNLKVYLISFPWTLSDMLCRLKSKGCIMVKPYEGSNHFSKHSDPALATDLGAISDDCASENLDRARRLTSSMNCRKRKANDREELVLSTAHFQNSEIAEKRLFGEMGGDVGVEIEIN
The following text describes a protein:
Function:
Catalyzes the oxidation of aldehydes to the corresponding carboxylate by coupling the reaction to the reduction of dioxygen to hydrogen peroxide. Substrates include glyoxal and other aldehydes (By similarity). Involved in disease resistance against the grapevine powdery mildew E.necator. Is sufficient to confer disease resistance to E.necator. Can produce hydrogen peroxide in response to E.necator infection, and this may directly play a role in the defense mechanism during plant-pathogen interactions.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MILDAAIVALADLPGTWELIVPNAGIASMHTAVTRYGTVVLLDRTNIGPSRKMLPKGHCRYDPKDEVLKRDCYAHSVILDLNTNKIRPLKILTDTWCSSGQFLPDGSLLQTGGDLDGVKKIRKFVPCGPHGFCDWEELKDVELETGRWYATNQILPDGSVIIVGGRAANSVEYYPPRKGGAVQLPFLSDVEDKQMDNLYPYVHLLPNGHLFIFANNKAVMYDYTSNKVMLEYPPLDGGPRNYPSAGSSVMLALEGDYSMAIIVVCGGAQFGAFIQKSTDTPAHGSCGRIVATSPHPVWEMEDMPFGRIMGDMVMLPTGDVLIINGAQAGSQGFELASSPCFFPLLYRPNQPLGLRFMTLTPGTVPRMYHSTANLLPDGRVLIAGSNPHYFYKFAAEFPTELRIEAFSPEYLFADKANIRPVIDESPEMVRFGEQFDVFVSVSLPVVGSMEVNLASAPFATHSFSQGQRLVKLTVSPTVPDADERYRIVCTAPPGGKIAPPGYYMMFAVNLGVPSVARWVQLVP
The following text describes a protein:
Function:
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for branched chain acyl-CoA, determining the biosynthesis of branched-chain of fatty acids instead of straight-chain.
Subcellular Localization:
Cytoplasm.
Domain:
The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.
Sequence:
MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERRIADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWESTGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGDAAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREVYKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVEHYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM
The following text describes a protein:
Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQKNFLPHNFRVYIYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRLGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQLYNHMGSDTTVVTQKIFQLIGLTNAIFVSFNITIILSSLELWIDVNKIATTGEANELLHTFLRWKRSYLVLSPHDVAFLLPGLGALAHACNPNTLGGLGGRITRSGVLDQPGQHGETPSLPKKIQKLVGRGGVHFSGVKIFRNCSIEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCVLIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKGIYYHLISHICSCSVAQAGVQCNLQCGKLICKYVGKFLLQIPSATIIYANISGHLCVAVEFASDHSDSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCSNRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVHFQRKKWRTEDYSSDEQPESESEPKG
The following text describes a protein:
Function:
Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.
Subcellular Localization:
Cytoplasm, cytoskeleton. Postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MRLSGAAMGQDQTKQQIQKGLQMYQSNQTEKALEIWIKVLEKTTDAAGRFRVLGCLITAHSEMGRYKDMLKFAVIQIDTARELEEPDFLTESYLNLARSNEKLCEFQKTISYCKTCLNMQGTSVSLQLNGQVCLSLGNAYLGLSVFQKALECFEKALRYAHNNDDKMLECRVCCSLGGLYTQLMDLEKALFFPCKATELVNDYGKGWSLKYRAMSQYHMAVAYRKLSRLADAMECCEESMKIALQHGDRPLQALCLLNFADIHRSHGDIEKAIPRYDSSMSIMTEIGNRLGQTHVLMGVAKCWLHQKEMDKALDGLQKTQELAEDIGYKLCLLKVHCLSEIIYRTKQQQHELRAHVVRFHECVEEMELYCGMCGESIGEKNCQLQALPCSHVFHLRCLQTNGTRACPNCRRSSVKPGFV
The following text describes a protein:
Function:
Involved in the biosynthesis of (1->6)-beta-D-glucan polymers of the cell wall. Required for viability. Involved in maintaining chromosome stability.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAGIKLTHKLYQYYQLATSFLYAALLIRWLILMPLVGSRFLPGGIHEFLIYLMFYSSIMEVIWLLRFHGFKYGLLSRTFLKDLNFIYLVSVIHFYDDYEHALILKNASYSSFIISLSLSQAYCHWCKLFKRKGVKERTLVWKVNTFVTLPILYLSEFALLLLNIQVKNYHSTPTLDIINRVVLLAYFPVLLTAYKKLLTK
The following text describes a protein:
Function:
Functions as a 5-hydroxytryptamine (serotonin) receptor. This receptor is a ligand-gated anion-specific ion channel, selective for chloride ions. Relays a long-range endocrine signal from the body cavity neurons to modulate distal adipose triglyceride lipase atgl-1 function, via the nuclear receptor nhr-76. Together with the G-protein coupled serotonin receptor ser-1 involved in male mating behavior. May mediate an inhibitory effect of serotonin on egg laying. Involved in regulating locomotory behavior, perhaps by modulating interneuronal signaling, acting in concert with G-protein coupled serotonin receptor ser-4. In the presence of food, plays a role in initiating and extending dwelling behavior, perhaps acting in AIY, RIF and ASI neurons, in opposition to neuropeptide PDF-mediated signaling. Plays a role in aversive learning upon exposure to pathogens such as Gram-negative bacterium P.aeruginosa strain PA14; perhaps acting in interneurons in response to serotonin released by the serotonergic ADF neurons.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell membrane.
Sequence:
MKFIPEITLLLLLFVHSTQAKGKRRKCPEGAWSEGKIMNTIMSNYTKMLPDAEDSVQVNIEIHVQDMGSLNEISSDFEIDILFTQLWHDSALSFAHLPACKRNITMETRLLPKIWSPNTCMINSKRTTVHASPSENVMVILYENGTVWINHRLSVKSPCNLDLRQFPFDTQTCILIFESYSHNSEEVELHWMEEAVTLMKPIQLPDFDMVHYSTKKETLLYPNGYWDQLQVTFTFKRRYGFYIIQAYVPTYLTIIVSWVSFCMEPKALPARTTVGISSLLALTFQFGNILKNLPRVSYVKAMDVWMLGCISFVFGTMVELAFVCYISRCQNSVRNAERRRERMRNSQVWANGSCRTRSNGYANGGSVISHYHPTSNGNGNNNRHDTPQVTGRGSLHRNGPPSPLNLQMTTFDSEIPLTFDQLPVSMESDRPLIEEMRSTSPPPPSGCLARFHPEAVDKFSIVAFPLAFTMFNLVYWWHYLSQTFDQNYQ
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MSMIKRVMVNRRPAASRVPERRLCNYMHRVCLQGRVEGYEYCTRHILEDKTAPFRQCAYTHAQSGRRCAYAAPKTDKRESLCQFHARKALQHRRSSSKKQHLVETPQKVIEALEHYCRDPQHSVDQSDTARNTVKFYDVESDDDTLADDRQFAGDSDADSVDNEAEDPLRHAGAFTVEEAASITRDKLVRLQSLYLGQFRRLRHVLADRRREYMRERGGPGRDLASPQDEAQYRRYRAYYRYHRCHGAEAVLRSRLKARQRADGPPSRKLCAHPACARAALPLAKLCRQHILHDRRQQLYESCPDCSAAFLRVRGPGDSCLLHTAPMPALPTFSEPLPDLPDMDQFQSMDDIAALGLDVVQPGSLFGLNQFGDPGESTDSALSDDGGPILALPADILADVVK
The following text describes a protein:
Function:
Responsible for methylating the 5'-cap structure of mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSTNVENLSHEHQDNAETQVGTGKDVYMEEKSDSAKTSNTDRKTEVLDRQNSQNDTKSHVRSLDSPDYPRRPQKRPTIRNEYCPQRPSNPSRNYAANDSYNRPQNRREKDVADTVRHHYNARPEMGLRNRRFSPIINLKRFNNWIKSVLINKFTPKKDLVLVLDMGCGKGGDLIKWDKVNVDGYVGIDIAEISVNQARRRYQNLDASFDAVFYSGDCFSTPIYKLLPPDQRRFDIVSLQFCMHYAFESEALARQMLENVSSVLPRGGIMVGTIPSSDRISYRASKMAPGTLQFGNAIYHVRFESPPNLSFRPPFGNKYFFYLEDAVSDVPEFVVPFEAFRALAEDYHLEMIWQKSFREIFMEEKNSTEFGPLLERMQVIDKNGNPGINGPEMEAADFYLAFAFEKRGV
The following text describes a protein:
Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MPRLPVKKIRKQMKLLLLLLLLSCAAWLTYVHLGLVRQGRALRQRLGYGRDGEKLTSVTDGRGVHAVPSTQRAEDSSESREEEQAPEGRDLDMLFPGGAGRLPLNFTHQTPPWREEYKGQVNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVKKLAVSPKWKNYGLRIFGFIHPARDGDVQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASRRYYFELLHKQDDRGSDHVEVGWRAFLPGLKFEVISSAHISLYTDESALKMDHVAHVPQSPASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPIARYQGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDEVQRRAFLFLNPDDFLGDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAEPGATLTPPTPPRPRDEGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNFSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAEAVDVTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLRLPGVRVGDADGESPEPAPAASVRPDGRPELCRPLRLAWRQDVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWEVNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYHSKRGMWSVRSRKGSRTGAS
The following text describes a protein:
Function:
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts.
Sequence:
MTKTSTCIYHFLVLSWYTFLNYYISQEGKDEVKPKILANGARWKYMTLLNLLLQTIFYGVTCLDDVLKRTKGGKDIKFLTAFRDLLFTTLAFPVSTFVFLAFWILFLYNRDLIYPKVLDTVIPVWLNHAMHTFIFPITLAEVVLRPHSYPSKKTGLTLLAAASIAYISRILWLYFETGTWVYPVFAKLSLLGLAAFFSLSYVFIASIYLLGEKLNHWKWGDMRQPRKKRK