lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with sorf-1 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-1 and the sorf-1-sorf-2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels.
Subcellular Localization:
Early endosome. Late endosome. Cytoplasm.
Sequence:
MPEEEFEWNESKLNALSEILTQWAPHDELKLENVILEAKMAWIHESTDAVALEKEFEKLLNTSFDPLMDYEEHQRVKNGVCSPAKSTKLDWITKWANIAEKLSISHINCSKAPHKTINFQRLQILPNMTSILAIAHTEADNVILIYGHTKEGIDFQTVLRHSYSNIPDGSLQTIHFLTKNLLDLYSQLFSRKITAEFKTRHFRCLPSFWLQYDVLAPIFEQFRAPRAPRIPLDEATSNWANRKWENYQYLTYLNDITGRVRGEVHNHPIFPWVCDFSEENGGFRQLNRTKYRLCKGDDQLREMYSREPSHHVPELLSDIGYMVYRARVEPKDNLCRHVRRKWVPEEYPSTMSRMYQWTPDECIPEFYDDPSIFNSCHPDMADLRFPEFVSSPQEFIEWHRKMLEHEEVSMNLHRWIDLVFGFNLAIDNSKNALNLHLCFVEKNRRGLRTTGMVQLFNRPHPIRMPLNYDPKLDNYHLKMESFGFGMTSEHRKEPEVEPDEDSHYQIYQKIKKVRRLRHNTYFSSMVSAMEVMAQIVLAPHLAGRFDDPDHIRRCIQLYSYRIPANYRRLFDFLFNTEQDFPDCDEFSFFVSVRLNIPTKILNFSEEFGKCVSLHILRKLDVIPPFSKRSQLIILKEVESLKKSIRLCDHMEQCVVAAFQQLLEDEEACIQSVHRLMPVITRSLSQSALEDLINPMIELIQCETSVKLLDRRFLMHVSICYGTHTFLDLFLPPIVEACASMNCDRSVVAKESIMWLAKRYGPVICAKFISSNVLRIMASCYEAFEMVGLEQQPKAVFNVVLQGDETCSRIESLLSEIVLTYSVTFITVQFLPFCVDLIEQFHKRSSVQLEPGLVSVFRIVELSIRSMSDHQLMNYLEEFIIQKVIYRVLTILLDASFQFSSMRVRIIIICKVCQLLHSITQKIGTENTRIYANQPFKLMFSTFSEIYETDEELRINLRKRPSENTLFEVPLWMVEDVVDKFAKEWGVPFLSSFCDDPAFLIPFVSNSSSSSSPPASIAHSPPSAFTAYSLGGMSSGNRLFSLSASSPVNSVNSLGGLSFCDSGSLSAVWCARVSAAVCGVDNYRFDHLSLCNYTGHQEKIRKLAAISNENSFVSASSDKTVKLWSIKPELDEIGCQWTYQKHTRPVHDITILADNSIASTDGVLHVWDPFRTTLLAQMEWDSKEGSGGNIMRVENVDRHILSAICSLHSTVKLFDSRVGGWTCELKVSPGPGLTRAITVRDKGNKMAVALSNGTLAILDARNGKINALAQTNSTHTVSVNWLSDTRLLVCDADECGIFLETNPRAHIVRKLQDPVSAACLTDNSLVTLQNGTILRVYRNSGELQIETKIRPDELPGTPTAVLPLPLNCSYLIGSSHGAIRLMC
The following text describes a protein:
Function:
Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes at mitochondria-endoplasmic reticulum contact sites.
Domain:
The SMP-LTD domain is a barrel-like domain that binds phospholipids.
Sequence:
MGLLLLILASAVLGSFLTLLAQFLLLYRRQPEPRADEAARAGDGFRYLKPVPGLPLREYLYGGGAEELAACSSEAGASSTPTPDSPAPPTLETCYFLNATILFLFRELRDTALARRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGDTVPFIKTIRLVRPVVASGTGEPDDPDGDALPATCPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRFVLTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKKIIKRKHTLPSYKIRFKPFFPYQALQGFEEDEELIHIQQWALTEGRLKVTLLECSRLFIFGSYDRETNVHCTLELSSGVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAMADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYQRPAGQSSQDSLGQLEESFLSSSCQAAYEEDAAGLSADTENRDLDSEFEDLASDVRVQTELKEETQPLSHSPKRTPTTLSIKPLGAISPVLNRKLISGIHPPPQKLPSKEGNKPSTLKTSETTEAAQVSKPQGPTFKPPVPPRPQGRVPLPPTDTSAQADPEAPEKPDKVLLPPPPADKPAEKQVKSVDQGEDVAAGKQSSAKQEGVKDLPSESSAPTKDSSDDPQMWESSEVLYRNKVGKWSRTRASCVFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEEVALGCLATSNMEYLTKFRLEPPTPKAMVTRTALRNLSMQKGFNDKFCFGDITIHFKYLKEGEPDHHIVPNVEKEKELHLVEEVSTLPKEEHFVGQMSLSENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETPLCGATERRIDRTLKNLRLEGQDPLLGLPPRVEIEANKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGSNSPSKRGNSAGIKLMRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETNDTRKKSVLSAALAKSGERLQALTLLMIHYRAGIEDIETLENLSLDQHSKKMNKYADDTEEDLDSEISQLIDSQPFSNISDDLFGPSESV
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, and very inefficiently of SUM3. Seems to be the only ULP1 able to cleave SUM3 precursors. Cleaves SUMO peptides better than SUMO-conjugated proteins.
Domain:
The N-terminal regulatory domain is required for peptidase activity in vitro.
Sequence:
MKNQSRVLNSELGDFDLSVLWDQILNFEGYGSYCFRPMDMDGYHKRSAGLNPCKHSGFSHSSRPMAPGIYRYPEVKSSLRRQVHAPVRILNSGRDRSTRQGSGNVLGTFLTRNNDMWKRNALDSSLRYRTDREVIDVDDELGDVEMISDDTSREGVENVAMEVDEVEEKAEMGNGLFSEVASLKNGSLRVGECSKANSSSLVVNRPVTDVTSFEAYRKVLESAVNRTSKLKDRGFVDFFKERGRALLRSLSSFWRQDEEPVEVVQREAFVPLSREEETAVRRAFSANDSNILVTHKNSNIDITGKILRCLKPGKWLNDEVINLYMVLLKEREAREPKKFLKCHFFNTFFFTKLVNSATGYNYGAVRRWTSMKRLGYHLKDCDKIFIPIHMNIHWTLAVINIKDQKFQYLDSFKGREPKILDALARYFVDEVRDKSEVDLDVSRWRQEFVQDLPMQRNGFDCGMFMVKYIDFYSRGLDLCFTQEQMPYFRARTAKEILQLKAE
The following text describes a protein:
Function:
Involved in endocytosis.
Sequence:
MTSRAKNVTTRIEVDIEKNREEGNWLKVIELAEQLKEKSPELVCLGDFLIGEGKLENYLEEWPPVEANIDRAKIGLIDAKRYLTLVINDAGIKAGVAMDAHLLLGKLHYASGQYSVALKHFKSAELHNLSQKKLPLRSLRIVAESYAVNGLCLQKDTTSTSKFKKAEKEEEMSKCFGLASDLSLLYMQKLEKEPTGTTGTTGTHSPQPPPSHKSLGIILEQAMQEGPTLSLQLGKPEEALERYRAFLCAVETHGGHAIRLKFMCQMAELILQVLLGDKYAPPLNSLPKPAIWKPKYYASLNQFVPRNECEETLLLLLIAESMAVRNAVLSQSPEFKEVRLSAYQDATRVYDLLTVATVRWGQVTLLQESLERSMKFSFEEPHLWKQHGLSLLATGRYVHALAVLKEVIRLEPNNASNCLLAAKICYEHLNLAVEGTNFSIEAKKKDMQCNSGLIGRCYLYIGIGYYLQAESCLLKKDKEELLNRALENFKNAVEIEPNDHLCHYYLGLQLAVLGKISEAQNHVRISLDLRSESSSTLHLLVLLLTAEREHKNALTIVENALEEYPDCLNLMYVKAHLELHEEGGEKALVTAKQMLELWKNLYEGQLNSDVPECDRKSDTRSVFQLYTSEMSDRDSSSLQLHNTAASRVEQALSEVASSLSSFSPRPGPQRAWMLQVEVWLLLAELYLAMDQPADVQQCIQEATQIYPLSHHIMHMKGLLHMHKQEWPEAKLCFQNAVAINPQHVKSLQELGLVYHYLGLQGLAETTFREAAKIDPKNHITWYNLGKVLEALGEYEKASNAMATALMEEKNNPILPFNSVPLCFE
The following text describes a protein:
Function:
Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKESPLITLVKRHSETHFANIKYGYYVLIISLVYLIGLALLRAFGRRTPSRSSSAFKNKIIYRLYDIDPAIHLGILFFAVLIPFYYHYSLTTQSTVYLKRLGRLSYALIPLNLFLTLRPNWFLRKNCTYTDFIPFHKWFSRIITVIGLLHGIFFIIKWAIDDNVSLKQKLILKTFNFAGFIISILVLFLLICSIGPMRRYNYRLFYIVHNLVNVAFILLTPIHSRPGVKFPFLLLNCTLLFIHIINRIVFAKSLMILNKNANYSKTNLVHVRLPRAILPDYFEPGSHIRISPYRRINPLYWLLPSHPYTIASLAEDNSIDLIIKETSTAEPGSQIESLRSNPKSFHLDQEKTYTLINSYPPSVPEECYSQGTNIAIICGGSGISFALPLFRHFFNKENVKYLKMIWLIKDYSEYELVLDYLKTNGLTFEKKLSNNKRISVFISGEYTAETRLDEITTNIDDENSEYEMGSFNNEDEDLSISNFNSENADSNDNTPETSHSPTKENGSMIEVKSKHSFTLSNELKSFNNESAQVNQNETWLFSCGPPSLLQLSKKYCNDERINFVCETYGL
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MPTHSSPQRKVTIKRKVRMRGKYFSLLIVFIVLAFNGVLAQNNSSTPKLRRSDFPEDFIFGSATSAYQVEGGAHEDGRGPSIWDTFSEKYPEKIKDGSNGSVADNSYHLYKEDVALLHQIGFNAYRFSISWSRILPRGNLKGGINQAGIDYYNNLINELLSKGKKTTYIYIIPKQIKYSLFSFLTTEHILVREYLLPSFHPYIKYQVLSTNDFRDYADICFKNFGDRVKHWMTLNEPLTVVQQGYVAGVMAPGRCSKFTNPNCTAGDGATEPYIAENKPNYELSHAFTFIYLRIITNLLLNVVQQASQKGQVGIALNAGWNLPYTESAEDRLAAARAMAFTFDYFMEPLVTGKYPIDMVNNVKGGRLPTFTAQQSKMLKGSYDFIGINYYSSTYAKDVPCSTEQVTMFSDPCASVTGEREGVPIGPKAASDWLLIYPKGIRDLVLYAKYKFKDPVMYITENGRDEFSTDKIFLKDGDRIDYYARHLEMVQDAISVGANVKGFFAWSLLDNFEWAMGYTVRFGLVYVDFKDGCKRYPKKSAKWFKELLNPKKSN
The following text describes a protein:
Function:
Able to transport with low efficiency all natural purines as well as purine analogs.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDGPDQIGPDVRPRRTFGDRVRRAARAFTTRDGLIGDYDYGFLFTPRLPFVKQKRRAAPFFGLEDKIPLVLALLLGLQHALAMLAGVITPPILLAGSSGANFGADESQYLVSTSLIVSGLLSAVQMFRLHVYKTRYYVGTGLVSVVGTSFATITVATGTFNQMYSTGYCPVDGSGNRLPCPKGYGALLATSCLCSLLEIGLSFMSSRLLKALFPPIVTGPTVFLIGASLIGNAMKDWAGGSGTCSSNPGNGALCPSADAPHPLPWGSAEFIGLGFLVFATIILCERFGSPIMKSCAVIVGLLVGCIVAAACGYFDRSGIDAAPVASFIWVKTFPLTIYAPLILPLLAVYMVIMMESIGDITATCDVSRLQVEGATFDSRIQGGVLGNGITCLLAGLCTITPMSVFAQNNGVIALTRCANRKAGYCCCFFLVVMGIFAKFAAALVAIPSSVLGGMTTFLFSSVAISGVRIMCSVDWTRRNRFILTASFAVGMAATLVPDWFSYFFTYSGDNHALEGLLQAVELVMANGFAVTGFLGLLLNLILPEDMEEDVVESEEDYEATTVVGMQGGSEPGSSGQNVKA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIMAAHQLFRAGLSSSNSNLAVFRQICLVGTTVKASSNLHLHQPTRNKGTDSILGNLFGYKFFDRFDERSKIVVIDGNIGAGKTSLAKGLADQLGMKYMKEATIHYFDEKELGEGKKYDDKFMGSCSLERFYADPFAKDGHSFRFQLAMYAVRFVQYADALQHLLETGQGVVLERSVYSDSVFMEAMFKMGYFRKECYDYYQEVEKISMYRLKPPHCVIYMDTPVADLIDNVKSRGLEYEQNIPIEYLEALEDEYKHKFLPAMQETSEVMVYDKNVPRDVDRVAEDFDMLKFEHLPWNEMNNDNFDKLYRFVRDKGRVAQSMWMPKYLPEITFGADQFNDLTIDFEQNHSIGKGFAPGFNPDQPFSKLFFK
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Subcellular Localization:
Cytoplasm. Membrane; Multi-pass membrane protein.
Sequence:
MREPLLQNEGTYSLAKEEEKIVTPHVTASAISIAFFRWLDPLFAAGSKRPLQLEDLPWLGERNSAAFLFQRLRGSSIWDAIWRPNRKLVIASGIVSLLHVLASYAGPFLVADFVASYGTSAGKGFALASGFLLAKISANLLERQRHFMLCLLGLHVESSLACHVFHKALKSSRVSTGEVVNLVTSDVRQVGWFCWEIHSVWTLPLEALLGLIILYRDVGLASFASVGALIACTLCNVPLASIQEKSQGKMMRERDCRMRATAESLRSMRTLKLHGWEESFLRKIERLRAAEYAHLSRYSYVQALSKYVFATAPSAMAVVAVALMAKLQPGKILSAVAVFRMLQSMQDGIPDFISSLVGVRVSMQRLSKFFEASEVESRPEFTGCGGAAAAAAIEVRAASFSWDRDPEHPTLKDINLEVPKRCFVAITGAVGSAKSSLLSCILGQMPKLCGEVIVRGTTAYVSQSAWIQHATVKENILFGSEMNKEKYDKIISSCQLKRDLEMLTHGDETRIGDRGVTLSGGQKQRLQLARAMYKDADIYLLDDPLSALDTQTSRDILKECIQGILCTKTVLLVTHHLQSIQMADKVIVMANGSLSVDCAEQSRAAAESATMDESSNQDRKEDPAEIQQKLEEPEAAEQRECGSVSGGVYWAYLTSVYRGGLIPVILVSLAIYQGSQAAATWEVARPRTSEAKLVMVFGLLSLGSSLASLCRVLLVAVVGLKTSQKFFLGMYRSVFLAPMSFFDTTPIGCILNRASTDQTSVDISVPLRLSELAGYMTELVTIIVIVSFVSWHVLPVFAFLASVAYYLQRHYIKTIRELPRLMEIQRAPIVHHFEESLSGLATIRAFHREPQFLGRLFHLVDVNNRPQFHNFASMEFLALRIGVLADVFFCALMLLLVAFPKSPGSAGVAVTYALSLTTVLTWTLWSRVDTEKRIISAERLLQYTQLHYQSPRRGKHVQPAEDWPQLGTLELKEVKVRYKPSAPMALCGISCKFPAGKKVGVLGRTGSGKSTLVQAIFRTVELTSGQILIDSLDISAVDVHLLRSKLSIIPQDPVLFEGSIRYNLDPLSTFSDDRIWEVLRKCELMTAVASKGAGLDSLVSGDGENWSMGQRQLLCLGRVLLKQSRIVVLDEATASIDSATERIIQTRIAENFQECTVVTIAHRLATILSNTDLVAVLQNGKLVEFDAPPVLSSNPSSAFATLPRKTMMSSSFRWGDVEDEEVDVLPPRKVVGPDEKGIKIITSWRRNEDTGKLIKVIETVRVTKKTKKMSPAVLHRKQLKRFGDVANATEGVTLVSVDEIRLEKPGSRNTRSDNVDLGLPSSGNTSLIVCRACGKKGDHWTSRCPFKDLLLKDDDAVIKPAEDHGDRGDVTSKQSTGKYVAPNRRPGGGAGSKETMRYRDDGNSLRVTNLSEDTREADLQELFGRFGSISRIFVASDRETGLGRGFAFITFVRREDAERAMKKLDGYGYDSLILHVEWAAPRERPVKERNDHNK
The following text describes a protein:
Function:
Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system.
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface.
Sequence:
MFLLPRFVLVSCIIGSLGFDNPPTNVVSHLNGDWFLFGDSRSDCNHVVTTNPRNYSYMDLNPALCGSGKISSKAGNSIFRSFHFTDFYNYTGEGQQIIFYEGVNFTPYHAFKCTTSGSNDIWMQNKGLFYTQVYKNMAVYRSLTFVNVPYVYNGSAQSTALCKSGSLVLNNPAYIAREANFGDYYYKVEADFYLSGCDEYIVPLCIFNGKFLSNTKYYDDSQYYFNKDTGVIYGLNSTETITTGFDFNCHYLVLPSGNYLAISNELLLTVPTKAICLNKRKDFTPVQVVDSRWNNARQSDNMTAVACQPPYCYFRNSTTNYVGVYDINHGDAGFTSILSGLLYDSPCFSQQGVFRYDNVSSVWPLYPYGRCPTAADINTPDVPICVYDPLPIILLGILLSVAVIIIVVLLLYFMVDNGTRLHDA
The following text describes a protein:
Function:
Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSPSLQEGAQLGESKPSTCSFSIERILGLDQKKDCVPLMKPHRPWADTCSSSGKDGNLCLHVPNPPSGISFPSVVDHPMPEERASKYENYFSASERLSLKRELSWYRGRRPRTAFTQNQIEVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRRAKLKRSHRESQFLMAKKNFNTNLLE
The following text describes a protein:
Function:
Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MNEEQENEILAISSIYPDSFSEIETIVGEEENDGFEDNDSQYSKIYQVIITPNISCLDENSLEDNNNSNNNNNNNNNNNNNGLIIDTSYDYLIYFKFKYTKEYPSNEPPIISIKATWLQKSDQSILLSHLEDLWNQNELVIFQMISWLQEESIEILNNHYKSIKKFSHYHLKKSLNTQQLNQNQNQFENQNQNQNQNQNQNQNKEKEKEKVPTIYTGQSVTEKKSKFQAHLAIVHSEREVQLVLNQLLSFKKIYEATHNMYAYRFQLENGEINEYYNDDGEDGAGDKMLFTLSKNQAKEILIVCTRWFGGILLGGRRYVHIVNTTKDILNLYNTNSLSQCSLEFN
The following text describes a protein:
Function:
Probable olfactory receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Mainly found at the plasma membrane. Also shows punctate cytoplasmic expression.
Sequence:
MNSTSNSSLGNTFISKTLKEKSLTVQVLVGILLYVNGLMIFTFLKKETFRDTRYILFAQTLFVDSALMLFADLTLVGSAYELFIHIISCYIFCTVMALLSICSPVTLVAMCLERYVAICLPLRHASISSPKNTINGLLIIWGVSSVIPLFIFIVSFTYTPPNAMNSYVVCSNDVMFQVKWLAEMRALSQQLLFVIMLCIVGSTYIKIMVAAKSASAENKKSTYKGLRTVILHGLQLILGMMQLITPYIDILTLKVDIMLFINVKFSNFMLFWIFPRCLSPLVYGLRDKKFYNALKYYAFCGIYVCKKHKIKDSKTIRGAVSIAIY
The following text describes a protein:
Function:
Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus, catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels, in association with DosP which catalyzes the degradation of c-di-GMP (PDE activity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. DosC regulates biofilm formation through the oxygen-dependent activation of the csgBAC operon, which encodes curli structural subunits, while not affecting the expression of the regulatory operon csgDEFG. DosC, but not the other DGCs in E.coli, also promotes the production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through up-regulation of the expression of the PNAG biosynthetic pgaABCD operon, independently of CsrA; Overexpression leads to an increased level of c-di-GMP, which leads to changes in the cell surface, to abnormal cell division, increased biofilm formation and decreased swimming (the latter 2 in strain W3110). In a strain able to produce cellulose (strain TOB1, a fecal isolate) overexpression leads to an increase in cellulose production.
Domain:
Is composed of an N-terminal sensory globin-fold domain that binds heme and oxygen, and a C-terminal GGDEF diguanylate cyclase domain.
Sequence:
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQVERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILYPVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
The following text describes a protein:
Function:
Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MCISEGKMDWRSWLRKKFQVRSQLLRGCMAEFLAVFVLMVFTEGCSASAIFTHRRNDLLFAAFGSGLAVTMAVYVAGGVTGAFLNPAIAVAFSVLGKLPWKNCFCYMIAQYLGAFLASLAIYAQYYDALNIFDGGHRQVLGDNGTAQIWSTYPQAFLSPQGAFVDQVFGTALLIIVVLSMVDKKNWKPQNGYFPIAIGLLIVVLDISLAYNAGAALNPSRDLAPRLFTYVAGYGTETFSVKGYTWFFVPVVGSHAGAIVGAVIYQLFIGAQWPQDDLDDSNSVSSMSIHEKNFSLAKRKNTRNFNLDITRDFKERNGISTVLY
The following text describes a protein:
Function:
A humoral factor that may play a role in stress tolerance.
Subcellular Localization:
Secreted.
Sequence:
MSRLIHLSFVLALLACLTGPISANPIDDDRERLNQLLSNPEPADDAELLRNTQEAIALYKKHASRTLPGHQVELDLDRDIRAFETEHLTVDGLPIQGGVWDLIKRGADKVPDEVKDQAKELAKTTAKVLFNKLTEYLKKKISGEDAEKKDT
The following text describes a protein:
Function:
Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
Sequence:
MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLETCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDVGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRILQWPKEQPFGEGVPLDGDDPDHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MSSFAHHHHGSLVEKDGRMSALRSSLRPYEAAEEMAAAAAAGGPAAAWGAVERGAGMMGDGFSVEDLLDLEELCEVDRDGGEQGEAAAAAAAAVEKERSSDSHGSSVVSYEPMPLLPPVMDLPAHDVEELEWVSRIMDDSLAELPLPQLPAAAAALAACGKPQHRRPHEGAASALLDPMRTPTICALSTEALVPVKSRRSKRSRASVWSLSGAPLSDSTSSSSTATTSSCSSSASFSPFLQYVDFPALVASDLLDEQPRSKKSKHGKNGKQKPKKRGRKPKHQQPPHLAAAAGGGAALPATGDRRCSHCGVQKTPQWRAGPEGAKTLCNACGVRYKSGRLLPEYRPACSPTFVSSLHSNSHRKVLEMRRKKETPVIVAAAAPAVASF
The following text describes a protein:
Function:
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
Subcellular Localization:
Nucleus.
Sequence:
MGSSKKVTLSVLSREQSEGVGARVRRSIGRPELKNLDPFLLFDEFKGGRPGGFPDHPHRGFETVSYLLEGGSMAHEDFCGHTGQMNPGDLQWMTAGRGILHAEMPCSEEPAHGLQLWVNLRSSEKMVEPQYQELKSEEIPKPSRDGVTVAVISGEALGIKSKVYTRTPTLYLDFKLDPGAKHSQPIPKGWTSFIYTISGDVYIGPDDAQQKIEPHHTAVLGEGDSVQVENKDPKRSHFVLIAGEPLREPVVQHGPFVMNTNEEISQAILDFRNAKNGFERAKTWKSKIGN
The following text describes a protein:
Function:
RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
Sequence:
MTMSFNITSDGSPTPRKGATRLSRAAGDLKIDTSPELLGQAVGGYHQNHYPYAPHRAFGSPLTPNMQGPKRTLGASTLGNQQMMMPHQHPFDGYKVSNCPSPKPKLVGHEEVSVMDSLLQRINGRSSPPDQYNSSSGSVPITPATDEFASTPPSSMDNSVLLVDAFELQKLKAELEEARSEVSRMNQEMHSHQVARSTMDHLSQSSDADYSYTGDVTEQTLTQLQNKFNASTRINSGWSNEPVRPGYNSGNSFVSNSYQAQPRPAVNQPSYRRNEFLNEPTHFPVSQSFRSSGMSSGLMNGMNGMSNSFNGMGNNVSNPPSRPGSAFDPMFNQYAMPPSMHAPGYPAPVGVIGSRLSPDANEFNVSNGLGPSPWNSQAPSEVGASQYVPPVEPLNYRRLLDRNMSCNWKYIVDKIICNNDQQASIFLQQKLKVGTQEQKYEIVEAIISQAYPLMVNRFGNFLVQRCFEHGTSEQIIAIAQAIRGNTLALSMDAFGCHVIQKAFDCVPEEYKATMVHELLRRIPETVIHRYACHVWQKLFELRWSDSPPQIMRYVNEALRGMWHEVALGETGSLVVQNIFENCLEEDKRPCINEVLASIDVIAHGQFGNWCIQHICEHGAPADRSRAIDHILRFATEYSMDQYASKVIEKCLKIGGNEFLDRYLERVCEGRQDRPRMPLIDIAGDQFGNYLVQYILTNTSTQHRDIVGSHIRKHMVSLRGSKYGSRVAMLCCNPALTTRPGPPSGMLPRYNNPMPRTTSGFSNYR
The following text describes a protein:
Function:
May act as a serine/threonine-protein kinase and guanine-nucleotide releasing factor.
Sequence:
MEVIKKEKKDKEKKDKEEKKDKEKKDKSEKKEKKDKEKKEKEKKEKKEKEKEKEKDKEKDGGLFSIVGGWVGNLTEPTPPPPPPPSSVSAQSTAEANAILLNPTTQENHKKAMDFWVTNTSTTTTTTTTTSSNNIPSLVSVQNNNTSNNNINNNNKTSNTTGSNVSSSNNKETVKINVTSLDSGGNNNASGKDISNEHSPKNRKEKEKEKDKDNKEDSINESPVDENRRKLVEGFMKSLQGCSDAIKVILDVFYQPLKKADLLSQEELKAIFSLIESISSFQQTILIDFKKYISNWNSTTQAQLHSTFLQFVGYLKLYKVYGLQYNYSLSSLCLLMFDNQRFESFINNAESKLVNEHKYSLAPLVPTSSSSSCVKPVSLSEILGSQYDQTTSQSTNNSSGSSFPAVTLRRTGHTFTGINSANSNNNNNNSGGGSSGINNSNSVTGKFTQEYTYSNLASLLILPIHFLARFHQFFKSLIDSIAVLNPDYKPYNNLYKQIVQVVKDIVNESVNINKVISISKSIKSPTIGLFNSSDIVQNRKFLKEGILIEQFNNQRISYYTFLFSDIILFTEKIEDTSTINNNTMMAYDGSFYLLKKLERIVNIQVDDPELGFEYRKGFQIKTKESSIFYMTSSEKEKSTWFQVLSQASLKSNQNQNQNQNNLTNSYSSTVAGGRNSTIGLGGIDDFNNNNNGNNNGSNNDDGPDEFEDAKDIALFCKMIISGQRPKVELTSQMLKISDPKPLFAALASTHFVNQLIFIPLTMNDKYMQMTLGMMSLNKSITHLTLSQNSINDPCAVALGDMLRYNHSLIQMDLSENTIADKGLISLIDGILSHPSITVVILTQNQITDTGAKHISKLLKFNQTLNALFLEDNNITQSMGAEIIDQWVSCHSTVLSRITLPSIPPEYSDRIKLKAISVTNRLDKKKKQLQVNQKSTTPSTSTSTTSSTIINNNKGLLDLGSCDYSEISLQLLNKLNMLSLDSRRISDLKELYLDHNCISSIPVSILKELKNLQILDLSNNQLSSLPSEISEMKELKLLNVSHNNLSSLPIELGTLCKLNHLDISFNFIETINVNSLSQLVNLKVLMMQRNYFNRLPIEIFTRLKSLESFSIAGSPCFHPIKQRIYEAIAIKATKLDLSDCGLSALPIEIGSISSLIELDLTNNRIKDLPPQIGKLSSLQTLNLSNNAIESLPWQLSQLTTLKVLNITGNPISFDGASNAKISIPDVLSGDDLIGILKYLKLASTKEKPCMRMKLMLVGQENVGKTSIAKCLKKEIIPVGKKLRQTIGLGTKKSKTPTLTEANGSIDFNAPQSINPLNTSLNISTDGINMDDWRPPSEDQSPPVTFSIWDFAGQEVYYSTHQFFISSRSVFIVVFDMSVYNPDETSRVPYWLQCIEAFGGNSPVILVGTHLDDLPNGVDVNQITQDIHSKYFTKFPNVKFFLPVSCKSGKNINKLQNHIVKLGKAEKKLGDLFSRSYFQLENLILSEREMNTPPIITLSEFTEMAISCGIPQTSITAAADFLKELGVIVYFDDPKSGLDQFIFIDPPWLTRLMATIITSKPNFVQSGVLDQSNLHQIWKPPDFPQHLHHVLLAILQKFEIVHPLPDPKATISSSSSSPSTTQKSLNNSGSNLKSSGSAISTSSSSTTNGNKTLHRTNSTTNTTSLLNVSRFGNGSISKGSSLSIIKKINDQSTSPSNSTTPSPNTSSNNFSDSITLVPKSSTKHLVPILLSEERPNSIEKLYDQILLKSQQQQPFLERIYQFEFLPIGFFSKLMIRTMHFTTVKEFWKNGLLVEKDDSQCLIESIQQFNQINFKAWGKNPASLLRFIIETAEVLISGWYKLHFHFLVPCNCINCNSILISNIGSINIINSTINLSSNNNNNVNIVNMSQQQHHQQQQSPSTSTSSSSSLTSSQPSLSTPLTSSQPSLSTSQPQLSTTTTTTATTTTSSSSQSLASQQSSSQIQLTHSSSLSSMSGSISTNSLNSNVSSSSSTPSLLSPPLLNPDSTSSSNETSGDILDLDFADYYDGESVSPGGTLKGKRKKNPSKFLTLYRNTNKPKINGTTGSGSSSSIVTTAVSSSSSSSSSTSLSNTSSRQLDLSKISHLINQQLSFGPSKTQDLRTMFLYEEIERIFLSKKFEVVCRSSITGEETIVRLDSLVPELMMSDIGPNFTLEYKDLEIIEKVGEGGFGIVYKGKLRGQLVAIKQITIDSGQAEAASEIYREFRREVWLSNTLTHPSIVSLKGYCLDPCCIVMEYIPNGTLYSHLRKSFSSITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLSDMNAAVVCKVSDFGETRAVVTSALGRDKLSNPIWLSPEIMRGDEYTEKADVYSFGIVLWEILTGLLPFDEYPVAHSSFMYQLEDEITNGLRPTIPQNSVCGHPDFITLITDCWQNDPLKRPTFIDIHSRLLIMSGLNPATATTTNSAKSTISTGFNSNSGATTTTKPKSSTISSGSGTTSPPQPHPQLVRKLTQNFTPIATSPTPSVIVSSVPTTTTTTTTSVATTPTVQTILAGGNITPKPSVPTAMKPNITPKPTLISSQKPPAPNPVPILKTPTPTNLSPTSISTPTTPTTPTTPTTPTTPTNSTSSNLKPTPTSKSNPSSPPQIATTATATQTPTPSPISVLKPPRSLPQKPVGTTQTTSTPPTNQTPNPTIVTRPPLPSSLSSNSINKPPSKPLPTPGGVTSPPPPPTTSSTTPIKFNSISAGNKTIGQSSTLPSSTLKQFTANNNTSPSGSSSLPNSTVSSPSSSFLLRPTGGTISKKLPAIPK
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with the central core region of the centromere.
Sequence:
MNSENASLFRNILNDTENLVQPLTQDESRLALFESLVQSDQLLVEKIEKWEKKVSKFTENSKSEKRKLQLELFQEIIDLKKCIAFKPIIGKNAIDNNISDLKKNLHSNKKLEAVLKEELHQIKKFSSDLQSLKSSMGERQKQQAAMSRRGKKSIIHSAIIQEKERYEKESQELFTFLDGFLDEHAPSLLEGAQASIDKNRPGKNQPSLNFENISKKDLTEEFKQVIENLMNNSIIPGSPYIEVKNERIVSFLVLASLCTVDPQDPSKVKLIPFSDEI