lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MDTEMSVNMSDFLHDQATRAPESLQQSYILMEDLYERKLWKQLTDALIVFFDTPETVPLRLPLYTNFVNSFRPNINQLKAVYMGLKAFESCSNDEALRNLNQIVNELDEEKYKDAYVYSIVAIARIKLISGKLDEARELLVKASKIIDHIDYVESLIHSSYYSVSADYYKAKADYAQYYRHCLLYLSCIDLDKCSHTELVERAVDLSVAAILGDIYNFGELLLHPVFELLVGTQHEWLHDLVIAMNVGDLPLFERLMGQINKMPLLQSSVALLGQKIRLMALIELVFQLPPNQRTLTFDTIARATRIPSNEVELLIMRALSVGLITGVIDEVTQIVTISSVQSRILNHSQIASMESRLREWNQNIKNLSNVVEISGKGVFV
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPTIRYQIKNEYGLGRSELYGAADKNDPEALLEGVAMAGLVGLLRQLGDLAEFATEVFHNLHEEVMNTASRGHNMILRVQQLETQLPAISNGLFHGSGSSCLSCREGIDWHCNIQVDHNLITAGDMPHFFMDMYEECHVPPQLFKLDKFDVGGDGACLKRYSDPSLFMMELTSSRLVEHDPRREKRTCKTKKKVSFSCGGEPPKSFLMSHFDSRLQPATSGQVLDKVTLQHVKLKPRQLNESVSHSLRSYMENHIDLLPTEQQVASETSIIQSIGMKSADLIKSATEVHAIVVDTSSNREKNQSRSPTKQEMTTAGDSEKQKIERMNFSDKQFEPTSEVQNVHSVYFMLEEKAVVSENKNITEGRLYGSQPSEVDLNLSVDQEVEQNGFSPDTECRSQNSSDGYISDEISSDLDNYMDALTTMESELETDAENQGNTDSVFVSTESQETDSDASDANEEQEELQAQYSKQYFIKNSASSPGFTTIFRKGAANLSFSDTLGHMAAQLLEENKNDSDFPPESDVGLGEMKGTHFEQTYNEPVKCKSSEHSLLRASDVSSSAVHREAFCRSSITDLTSTISLVTLNIMETSPSYERKTDQAVSHLDGESPCKIDASELPSEEKINMLHGEFAKNPGILSDSLHHMTDVKLLMKDDIPKESDPNEYIKEQSTHDVVSSNRPVLHLQKQHETALEVGTTDIEVSDHIKSQESEKHDQGACCLVKPAVLDEDLGNAITGNDSLAASTLVLTHENADAVTQGITPIPNMSTSKEDILSGAHESPWTFTGQKAFSDNTDVLSEPVGIILSTENELPKCNPEESGDDITSDVDFSESNMPSSNETICGELSFEGSIPFQCNSDLHKNTSGSVSVPAPLIRLNKDSISETILQQSSEQQPQLASSAPLPEDNVTSEDTKEILPGRLTKPPRASLVSSCSVAQPPSGSNTDISLSTVENEHSGELLAGVEIAGSDCTVQSPKSCDITVAVKGGYEDILHSDRKLVHPALELPHEEDKPVHDGNAFEEDCMRATELPSTVENESSRDISVSKGSKTYPPTLSEVIPSLNERCQDLELKRSQNGIADGEKHKDTHEVAGSALTVNGKLPLPPSTKPKKSGHGSLSTEEKDSSSLHYLTTPTTENEKPTNKLRLVISRPNDPLIEAIASHDKSKLRKAPQLIHSLPKSDEKGSFLEQIRNKSFNLKPMVAPTVKFKGGPPTDVKVIAILEKANAIRQACAGSDDDDDEEDSWKSDS
The following text describes a protein:
Function:
Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PH domain is required for membrane targeting.
Sequence:
MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPFLIGHLKDSTHNDIILNILIEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHVDEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVAQAKERESREVTTYL
The following text describes a protein:
Function:
L-tryptophan aminotransferase involved in auxin (IAA) biosynthesis. Can convert L-tryptophan and pyruvate to indole-3-pyruvic acid (IPA) and alanine. Catalyzes the first step in IPA branch of the auxin biosynthetic pathway. Required for auxin production to initiate multiple change in growth in response to environmental and developmental cues. It is also active with phenylalanine, tyrosine, leucine, alanine, methionine and glutamine. Both TAA1 and TAR2 are required for maintaining proper auxin levels in roots, while TAA1, TAR1 and TAR2 are required for proper embryo patterning. Involved in the maintenance of the root stem cell niches and required for shade avoidance.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKLENSRKPEKISNKNIPMSDFVVNLDHGDPTAYEEYWRKMGDRCTVTIRGCDLMSYFSDMTNLCWFLEPELEDAIKDLHGVVGNAATEDRYIVVGTGSTQLCQAAVHALSSLARSQPVSVVAAAPFYSTYVEETTYVRSGMYKWEGDAWGFDKKGPYIELVTSPNNPDGTIRETVVNRPDDDEAKVIHDFAYYWPHYTPITRRQDHDIMLFTFSKITGHAGSRIGWALVKDKEVAKKMVEYIIVNSIGVSKESQVRTAKILNVLKETCKSESESENFFKYGREMMKNRWEKLREVVKESDAFTLPKYPEAFCNYFGKSLESYPAFAWLGTKEETDLVSELRRHKVMSRAGERCGSDKKHVRVSMLSREDVFNVFLERLANMKLIKSIDL
The following text describes a protein:
Function:
Essential to lactate transport.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSSITDEKISGEQQQPAGRKLYYNTSTFAEPPLVDGEGNPINYEPEVYNPDHEKLYHNPSLPAQSIQDTRDDELLERVYSQDQGVEYEEDEEDKPNLSAASIKSYALTRFTSLLHIHEFSWENVNPIPELRKMTWQNWNYFFMGYFAWLSAAWAFFCVSVSVAPLAELYDRPTKDITWGLGLVLFVRSAGAVIFGLWTDKSSRKWPYITCLFLFVIAQLCTPWCDTYEKFLGVRWITGIAMGGIYGCASATAIEDAPVKARSFLSGLFFSAYAMGFIFAIIFYRAFGYFRDDGWKILFWFSIFLPILLIFWRLLWPETKYFTKVLKARKLILSDAVKANGGEPLPKANFKQKMVSMKRTVQKYWLLFAYLVVLLVGPNYLTHASQDLLPTMLRAQLGLSKDAVTVIVVVTNIGAICGGMIFGQFMEVTGRRLGLLIACTMGGCFTYPAFMLRSEKAILGAGFMLYFCVFGVWGILPIHLAELAPADARALVAGLSYQLGNLASAAASTIETQLADRYPLERDASGAVIKEDYAKVMAILTGSVFIFTFACVFVGHEKFHRDLSSPVMKKYINQVEEYEADGLSISDIVEQKTECASVKMIDSNVSKTYEEHIETV
The following text describes a protein:
Function:
Transcription activator that binds DNA on 5'-ACTCTAC-3' and promotes auxin homeostasis-regulating gene expression (e.g. YUC genes), as well as genes affecting stamen development, cell expansion and timing of flowering. Synergistically with other SHI-related proteins, regulates gynoecium, stamen and leaf development in a dose-dependent manner, controlling apical-basal patterning. Promotes style and stigma formation, and influence vascular development during gynoecium development. May also have a role in the formation and/or maintenance of the shoot apical meristem (SAM).
Subcellular Localization:
Nucleus.
Sequence:
MAGIFSLGGNNNNNGDEEEENQQQQKTNWVWYRSNANTNNINPSSSQQVWQIPPEQMLMHHHSHPQQQSLDLYPGHQIDVSDLATSSRSITISCRDCGNQAKKDCTHMRCRTCCKSRGFDCSTHVRSTWIPVARRRERQQQLHMSTSGGGGGSGSGGAGGGGSSIPKRHRDPTLPGTSSSSRLPSHSAGLEMGEASFPGEVSSDALFRCVKMSGVDDGGDGQYAYQTTVNIGGHLFKGILYDQGPESSYMSGGSGGSDHQSSSAGGGGGGHPFNPPVVTDGGGGVSSAMFVDPNSGGYYSSNMTTSVFMPPGTQFYQNPPRS
The following text describes a protein:
Function:
Part of an ABC transporter complex. Responsible for energy coupling to the transport system; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MTAALTFAAVSYRFTGNPTPALHRVSLSIDPGRRIAVLGRNGAGKSTLLLLAAGILRPQEGQIRLGDTPISYSRSGLRHLRRHVGLVMQSPDEQLFSASVWQDISFGPLNLGLSPAEARRAVHEAAALCDVSDLLDRPTHALSGGQKARVALAGVLAMRPQYLLVDEATSGLDRWARRQIVQVFDRLAAQGKTVVLATHDLALARRWADLVIVLDAGSVAAVGTPARVFADETLRHLIAPAEDWHDDW
The following text describes a protein:
Function:
RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Ability to repair alkylated DNA and RNA is however unsure in vivo. Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation. Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (By similarity). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm. Note=Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'-O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (snRNA), N(1)-methyladenine from tRNAs and internal m6A in mRNAs. In the cytoplasm, mediates demethylation of m6A and m6A(m) in mRNAs and N(1)-methyladenine from tRNAs.
Domain:
The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found in the bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As a consequence, the domain is not detected by protein signature databases.
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTMHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDTVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLAPQNVRDDVENDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEAVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDVSMPLPFDLTDIVSELRGQLLEAKP
The following text describes a protein:
Function:
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Sequence:
KGVRSLESGHSVLGAELTAAVSAGVESGAAHPASACCGRLTASPRPRPGSSHTGRSCPDSGFRPAVLCSRHASTSSAPPAPKGLSSRPPAAAPPEPRPVRARTVRSSHLAGAAPTPFRARTRELQEESGLTVDALHKVGQITFEFVGDPELMDVHVFCTDRVQGTPVESDEMRPQWFRLDQIPFGDMWPDDSYWFPLLLQRKKFRGYFRFQGQDTILDYTLHEVDAV
The following text describes a protein:
Function:
Involved in iron-sulfur cluster biogenesis under severe conditions such as iron starvation or oxidative stress. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. Required for E.coli to sustain oxidative stress and iron starvation. Also necessary for the use of extracellular DNA as the sole source of carbon and energy.
Domain:
Consits of two domains, an N-terminal domain that resembles the so-called Fe/S A-type scaffold, and a C-terminal domain that shares sequence identity with Nfu-type scaffold proteins. Both domains are important for NfuA to fulfill its function in vivo. The N-terminal domain does not possess the three conserved cysteine residues thought to act as Fe/S cluster ligands in A-type scaffold proteins, but may keep the ability to interact with apoproteins.
Sequence:
MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEATDTALKFDLLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVADDAPLMERVEYMLQSQINPQLAGHGGRVSLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEKQLLNEFPELKGVRDLTEHQRGEHSYY
The following text describes a protein:
Function:
High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKPSPQRTLIKKLLVLLGPLVAVPLLFFGPEYRCLFSIIFLSTYWIGEAFPIGVTSLFPLALYPILQIVPSKQISPVYFKDSIVLFMCTLIMAMAVEATGLHRRIALKLLTKVGAKQPVMLLGFMCITSFISFFVSDTACTALMCPTAVALLMSMSDAVQHLKEDHRKPKPPPDDATVAEKLRIDDMTPQDAGFCKALILACAHASLIGGTAIITSTGPNLVFRENIHKRYPEGQVTMTYLQWMVFAIPPMFVYLLASYIILVCYFMGPSTFARWFERPSKEEAHLKKLIEKNIQTMYEDLGDVSWGEKSVFVFFILLIGSWISRDPGFTPGWGDLLPHRNFISDSVSGVLISCILFVWPKDPFDPIDPMAPILKWTDMKSKFSWSCTLLIGAGYAISEGVDKSGLSRLISCGMKNIFVGMSSLPLQLTVTTIIVIMTEFASNVSTGSIFIPISLGVAESMGVHPLYLALPTTVACSFAFMLPISTPPNAVVYDTKVISMVEMIVCGFLLNIACILITSLNMNTWTYFIFSLNIFPENIVISSENSSYPVC
The following text describes a protein:
Function:
Overexpression causes cell cycle arrest.
Subcellular Localization:
Cytoplasm. Note=Barrier septum. Cell tip.
Sequence:
MSVTPPNVQFNLNGDSDHKSDNSSSSLENKLDTELKITSPPRNPPQRLHPVDFSEHADTDDDMNHPLPRVQSPVHIKNHIDPKLAEDRYRSSAARHFEPISIPPSAITSEDEDDYHGSANSSTVLPPRTENALHAASPKPSGSTGYTSPALSQNSGSGGEGESDEGSFNTQHHRSPIFQAYPSSEDLVGDPNDPYRRTRRAPIKTNPHDIPSQFIFRKLGLHHGKHGHHGHSGSLSLKSLVPNHHDKHDKHDKHEKHHSSLDLRRFFKSHQKTDKEKKPSVSKSKSSANLQDDHFGLFKKYGKFGRMLGSGAGGSVRIMKRSSDGKIFAVKEFRARRPTETEREYARKVTAEFCIGSALHHTNIIETLDIVEENKKFYEVMEYAPYDMFSIVMSGKMTMPEVYCCFKQLLSGVAYLHSMGLAHRDLKLDNLVVDSNCFVKIIDFGSAVVFKYPFEADIVEATGVVGSDPYLAPETLVRKLYDPRAVDIWSSAIIFCCMALRRFPWKYPKLSDNSFRLFCMKQPSNDAESPSDILADIKKQRLVEQGCEPIRKTDESHSPNSKTDNSSTHKQELYGPWRLLRLLPRETRAVIAHMLELDPVKRYDIHRVFADNWINDISMCHMENGKVIHSPTHVHNLVASEESPAPPAKH
The following text describes a protein:
Function:
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol. Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Domain:
The C-terminal region is required for dimerization.
Sequence:
MDRPVAAAAAASAASCEGAGGPGPGPGASWRPSRVAGGASASSRHPSIETLDSPTGSHVEWCKQLIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPLFPGESIKAIVKDVIYICPFMGAVSGTLTVTDFKMYFKNVERDPHFVLDVPLGVISRVEKIGAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQRKLGIFENLNKHAFPLSNGQVLFAFNYKEKFPVNGWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLTIFDARQNSVADTNKAKGGGYENESAYPNAELIFLEIHNIHVMRESLRKLKEIVYPSIDESHWLSNVDGTHWLEYIRVLLAGAVRIADKIESGKTSVVIHCSDGWDRTSQLTSLAMLMLDSYYRTIKGFEALIEKEWISFGHRFALRVGHGDDNHADADRSPIFLQFIDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRIKEDVYTNTISLWSYINSQLDEFSNPFFVNYENHVLYPVASMSHLELWVNYYVRWNPRMRPQMPIHQNLKELLAIKAELQKRVEDLQREMATRTISSSSERGSSPTHSATPVHTSV
The following text describes a protein:
Function:
May have a role during differentiation processes.
Subcellular Localization:
Nucleus.
Sequence:
MASTNSQDMVCGSVTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAVVGSCISKPDLIVLLEQEKEPWMAVNEETGRPSPDLEADYDAENISPQNRIYNRKFSKQSIKQLSRTFDPKGSWFSNGPNYSTFHGLRDCQSDAGQQITNKEGVPPHTCQTLAHNTEKPYECKECGKCFGCRSTLTQHQSVHTGEKPYECKECGKAFRLPQQLTRHQKCHSGEKPFSHNEGRQAFQHPNLLKYPKAIHTGAKAFACRECGKSFNRVSSLVEHGLIHADVKPYECNECGKAFKRHRSFVRHQKIHSGERPFQCKDCGKGFIVLAHLTRHQSSHSEEKPFECEECGKKFRTARHLVKHQRIHSGEKPFECNVCGSAFRLQLYLSEHQKTHMEEKYLECNVCGKAFRLQVYLSEHLKTHTEENPFKCKLCGSAFPNKYQLNKHLTVHTDGKPYQCKECGKCFRQRSKLTEHESIHTGKKPFQCEECGKFFRLNTLLIHHQKSHSGERPFECKECGKAFLLPSQLNSHKIVHTSKRPFECKVCGKSFKRESNLIQHGAVHAGVKSYECSECGKGFIHRSSLFHHRKIHSDEKPFKCQECGKAFVVLAYLIQHQSIHTGEKPFECELCGSAFRCRSQLNKHLRIHTDVKLFQCVED
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRFQVRNEFSLGQPQLYKEVNREDPKAVLDGVAVAGLVGILRQLGDLAEFAAEVFHGLQEQVMTTASRSQKLMVRVQHIEAALPPLEKAVLAQTSHIHFAYTSGLEWHPRIRNEKNHFIYNDLPRFIMDSYEECQDPPRLHLLDKFDTGGPGSCLKRYSDPTFFKKASANPDEANVEQVRRSRKGQRSKKKRGSQRNGDVLRGASVSNRSSRMQYIPPIANGRSSSSPTASTADMALKSDLGDNSISFDSKTESEYIEYAAHPSSSLLAEEQESKESPSSKSVQNDALNSVLPDDQTGFVDNSPGSSLQDQVTSGSSGVNWDEKVEIVDPKGQQNCIDETTEMLLTEDDLDANEGGAGSFRIVEQMDVLFDDENILEPSRNQIDEIESEPDNFMDALNTIESESENDLDCQTKREVERFASVVNNKGPDGVHEITMDCSDHQTPTLESHTATSYVSSEEETPTDLSNSTSPECPAHKHMPQIATELSNSDHIVETNRTDIFDCSRFESVSGDSTSSGSGTTNAQDKTISSLCEAPQSPADVSRNNSTSFGSGTTNEQDNLISSLCEAQESPADISRNNTTSFGSGTTNEQDKIISSLCEAQESPADICRNNTTSCGSGISNAKDKIISGLCESQESLGDISRNNSTSCGSGTANAKDKIISGLCESQESLADISRTNSINFWTNGGLLGLQPSKPPDFTMSSPITQDSAYRSTETVGVSNHAYTLIADEHEAENAGCKEMSSDYQEDGISPKEISKGFSSTELYPKLGNIGDSPKSNVFSHCMEDGLKKTNTMEPGTLLPVAPCRKSTSNEANQENDENSSLVFGLGRRLLVNGFGRKVPHSHDEKSEPASYSNAGVLDQRNEHHRVEHQAFPDTSFKENFEHGFAVESPPSSPPLEHMKISFHPMNGIETSILKLKLSDGSQSHGSVKEMFQSFQLVPEPSIPLHEFGSDSDDDTFCRSSPYISDDCLSHLSESNSEQWESSENLECKNHDLYDALCGIASAERISTSLEVGGISHNATYGDGGIQSVHTDNGLEHSLSDPLLDLPSLDALEPVLQQEAKDDSVPKDLHGLKCSGDSTPGPPPLPPVEWRVSKPTLNVTDEKQDVSEGFKHVFDTQILGPLTLQQPKPAPAQQQQINEESISIKPKCKEDQHVNGQKEADQALNGKGIDEKEDFLQQIRAKSFNLRRTVPAKPTITPVSATNVKVTAILEKANAIRQAVGSDEGEDDDTWSDA
The following text describes a protein:
Function:
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
Sequence:
MFNFANVYQQIAQHPQLQLWLNTLPQQLTDWQAKQHGDLDRWMRNLKKIPVGQPEVIDLKNAVAAHNHQPLAQGEQKKLEAVLKTFHPWRKGPYHLHGIHIDTEWRSDWKWDRLLPHISPLKNRLVLDVGCGNGYHMWRMLGEGAQQVFGIDPSELFLIQFEAVRKLLGDDQRVHLLPLGIEQMPELNAFDTVFSMGVLYHRRSPLDHLLQLKNQLVAGGELILETLVVEGDEHTVLVPFDRYAQMRNVYFFPSALALKVWLEKTGFVDVRIVDENITSLGEQRTTEWMTHNSLPDYVDPQDPSKTIEGYPAPRRAILIAKKP
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MGNTFTYFQNESENNLPSFKIPKIPTFEEISSKLSKEGVTKKKLEEIFEECCFMSIDFFFDKYKSSDLLKCLHQNQKVEWMFKCKQCSNDACGYICCKCFLNGNHIEEGHTFSLYESQINDFCDCGNEEILKKSGFCSTHAGVNEKSKKEIIDRLPFFIKKDVHIFFRYLFQYLQNLTTSILLEKNSASVEVIIGWLKEICSVSSILVHIIAEEFTSRQLEIGEDSKSRFKLNEHKPLPYKNEAESIQRLWESHHFLGYIFSKVAILDKFLPLLSLLVDNHSTFKVSVFEEYLKNFITIFAPRDRASSRIMQFLGIVYIENIKISLPFATGYSRHNVIELILRSHKTIYVPLLLPFYQSSSSKDITKEVMLQTDVPAIPKLLKEPSVVRYFCSQSDKFKLLFEYARELHKFTSLQFVDPSISTTKFLLVQELNLIASVKNIMVTLDGMVGDTEFRQEIIDSIAEKLVSNIGEIKKRPVFERCGIKLPHKDFFQKFTYAEIPVHFPLYRMLSTFLLMTKMDPSLLYTKYGMLESDVIDMVHTIVLFRVFYITYDPTETLENCTDITMTNDLHILQVAVCLLGSKKFLYSFFNVVSSIEPTPSAFNEAFSILVSSLQIRATLVPTKKVIEFHLLQGLFSNIFFKTHFRSFDSVLMGVSENDICETYINELAEPTGRALELKDQDNWKYYDPYYPHFSLTYRNAIQNGSKKRFKKYMESKKIPSESNPLPPVLEELPTELLGLTKIFNDQTLIEIIFCILADCLYPTFIGYDNSIELQPILKMIISNPQIILNDFFYLLVLSIKSFKEITLPILTKSEIDEIVNSVINFFDHEKLIKTQILINNSTDQNEKEKLLIENQDKILENLTDNIKINYDETTTTTTTTSIEEKENVNDKEIFDSLKEEEKEKEEEKEKDKENEEIVVEKEKLKEFSFNGKDNVIYNLLRVYNVEVKIGFKERLSVLDLLFKFWDLMTNQTQYLQLRGSLLYIFSFLKEFDPIFQKVFDEHKVDLVHDVEHSNQDDLAHKKSMAEKRLKLLEQMKKQQQSFFDDLSDQEGEEEEGKGQDNKKDEKDDKKDDKKENENKENKDNENKDNENKDNENKDNEKELNDKSNIDDGRNETTVTTKVKIIEEVEEEEEEENIIKIEKVEEKVEEKEKEKHKHDHDHENEDEDEHSEFEPCVVCKLSEKAGRLFAIAYVDLSSVSHQNTKQSIDEIKMDKLNVGYNENYKKFLEKYYSILKQNSAKTIPTGEKPESFSVYLFSNSVSTYVTSCGHNIHKRCFDNLMKGQPLDPFLATAFKCPLCNRHSNITIVLGEPNDTIQYRSYVEDLFKKLCYYDFVSLMNKDSMYSIDEYLWKFIIQNIETLELKSRKTTLYNDNDQQPAYFLMSEHDFQRELTTTARLHRVIAQVDFKQKVPHAELPIRNNGIFFSDAFIASSYSIWLCKFHPSQLFDIILDGLQYYIFKMVIHHCIKNNIMPTTGDENTNQYISNAINLITNEFNRLFYGEKPLLDNDNTFREEFINQLLPFVRKLYLLYIIISRANPKQPQPPILTMEKLTDINYCLSCFKFNGLLDMVNIVCSKANFENTLNQFLRKDKMTSQLSAFPQVFCSFPPPLKYDSLPKWIDLPTRFVDFMKDHLFAGHCSKCGALLKLVCLMCGNCSCETSSCRIDLFFHKPSCCTQYPLAFYHAIDRPFAKSFKLEQGFLKAQTPTFISIYLDQNGHKIATPSIHAKLSNKKLSKLYKCWIDCSNRRKYFIEKK
The following text describes a protein:
Function:
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-4' (H3T3ph) during mitosis and interphase. Function is essential for chromosome organization during mitosis and genome organization in interphase cells, thus playing a functional role in gene regulation. During mitosis, may act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity). During interphase, associates with the cohesion complex and mediates pds5 binding to chromatin to ensure correct sister chromatid cohesion, chromatin organization, and also functions with Pds5-cohesin to modify Polycomb-dependent homeotic transformations. Function during interphase is required for insulator activity, nuclear compaction, heterochromatin-induced position-effect variegation and PcG-mediated pairing-sensitive silencing.
Subcellular Localization:
Nucleus lamina. Chromosome. Cytoplasm, cytoskeleton, spindle.
Sequence:
MLSISKTKMDFLEEGRWKDPFDELLDSRTKLSKMNIVKQNVRVTYNIDSSVENSSYIEIKEPNHKNEPLTLEDCSIKVYCPSDSISTPCDKRLGGTTGLFETDLSPITRLKLEGVEDSRDKCADTNEADLYVNVEILFQNINSSPKKCSNFGKKRLSNLNKMVTAVHPSISLNPGKWRKSLNNFIRSKITETNFTKKVERRSSICQDRKSLVLKGEHKFENKYEEDVLKYCHQCTPLPFNTAYEQHKLLNTKKIGEGAYGEVFRCSRNQEVLKDHISDIVLKIIPLEGSTVINGEKQKTFSQILPEIIITKKMCSLRTSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSENDHPELFGDNQLFAVLELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLGNILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFNDLSRDEELFQATGDYQYDVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLDSVKYKSINTKVHRMYIDKIKELKNIIMTFESASHCANYLFNLN
The following text describes a protein:
Function:
Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MATKSTGGTEKTKSIEVKKKLINVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTSVADQEEERKAFMEAGLNHCLEKPLTKAKIFPLISHLFDA
The following text describes a protein:
Function:
Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins. In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication.
Subcellular Localization:
Host nucleus.
Sequence:
MPFVGGAESGDPLGAGRPIGDDECEQYTSSVSLARMLYGGDLAEWVPRVHPKTTIERQQHGPVTFPNASAPTARCVTVVRAPMGSGKTTALIRWLREAIHSPDTSVLVVSCRRSFTQTLATRFAESGLVDFVTYFSSTNYIMNDRPFHRLIVQVESLHRVGPNLLNNYDVLVLDEVMSTLGQLYSPTMQQLGRVDALMLRLLRICPRIIAMDATANAQLVDFLCGLRGEKNVHVVVGEYAMPGFSARRCLFLPRLGTELLQAALRPPGPPSGPSPDASPEARGATFFGELEARLGGGDNICIFSSTVSFAEIVARFCRQFTDRVLLLHSLTPLGDVTTWGQYRVVIYTTVVTVGLSFDPLHFDGMFAYVKPMNYGPDMVSVYQSLGRVRTLRKGELLIYMDGSGARSEPVFTPMLLNHVVSSCGQWPAQFSQVTNLLCRRFKGRCDASACDTSLGRGSRIYNKFRYKHYFERCTLACLSDSLNILHMLLTLNCIRVRFWGHDDTLTPKDFCLFLRGVHFDALRAQRDLRELRCRDPEASLPAQAAETEEVGLFVEKYLRSDVAPAEIVALMRNLNSLMGRTRFIYLALLEACLRVPMATRSSAIFRRIYDHYATGVIPTINVTGELELVALPPTLNVTPVWELLCLCSTMAARLHWDSAAGGSGRTFGPDDVLDLLTPHYDRYMQLVFELGHCNVTDGLLLSEEAVKRVADALSGCPPRGSVSETDHAVALFKIIWGELFGVQMAKSTQTFPGAGRVKNLTKQTIVGLLDAHHIDHSACRTHRQLYALLMAHKREFAGARFKLRVPAWGRCLRTHSSSANPNADIILEAALSELPTEAWPMMQGAVNFSTL