lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Also participates in cell permeability to H2O2 and H2O2-mediated signaling. In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTYARFLAALRTRVRIRSLLLRQCLAEALGVFILIVITLSGAAQSVTSAGAKGGYFSAAFSGGISVMVAIHISGGVSGGHLNPAFSLAMCLLAQCPWWKLPIFSVVQIASAFVGAGTVYILYYDAIHHYSNGTLAVTGPRETASIFATYPAPYLSLWNGFFDQVLGTAVLVVSILALIDPRNRAHPRPAWSPWGWRCWWSRCAWPWAPTAAAPSTRPGTWARGSSPTWPGGAPRCSVPGGAGGGCRWWPRWWALRWARPSTSLGWASITP
The following text describes a protein:
Function:
Lacks deubiquitinase activity.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope.
Domain:
The N-terminal region that precedes the OTU domain mediates interaction with cellular membranes.
Sequence:
MEAPRSAPRERERARTTSGSDQVHSWILVTSQVLSAAWRIARAFVMTTLSPLSATFSYFRSLYLYLGHQLKWWIGYLQRKFKRNLSVEAEVDLLSYCAREWKGEAPRARLMRKAYEELFWRHHIKCVRAVKRDNYDALRSVLFQIFSQGLSFPSWMKEKDIVKLPEKLLFSQGCNWIQQYSFGPEKYTGSNVFGKLRKCVELLKLQWTEFSGMRDHHKRGSMCNSLFSDAILECKLYEALKFLMLYQVTEAYEQMKTNKVIPSLFRLLFSRESSPDPLSFMMNHLNSIGDTCGLDQIDMFILGYSLQVKIKVFRLFKFNSRDFAVCYPEEPLREWPEISLLTENGHHYHIPVF
The following text describes a protein:
Function:
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (By similarity). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. Methylates GPS2, protecting GPS2 from ubiquitination and degradation. Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSQPKRRKLESGGGGEGGEGTEEEDGGELEVAVPRPRRTRRERDQLYYQCYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASDIWQQAREVVRLNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGCGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLELRLSFWSQMKQLYGVDMSCLESFATRCLMGHSEIVVQGLSGEDVLARPQCFARLELARAGLEQELEAGVGGRFRFSCYGSAPMHGFAIWFQVTFPGGDSEKPVVLSTSPFHPVTHWKQALLYLNEPVQVEQDTDVSGEITLLPSQDHHRHLRVLLRYKVGDQEEKTKDFAMED
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MDFDDETGDFFGEDELFGDTDVVGDDEAIEDNRYDGVKGGGKDEISDFLKKEKKETARKKTNPLALLNERSLVGKSGIQLLKESFTNYKPNPKADPYSQLPELLKKYQHWAHVLAPRMKFEDVISRCEQLGEKRSIKVYMAKIRMGMPLTDEDFETTGSRKRRNSDDRIITTEYASDRERSFSPPPKGKSISPPPKRAEPSQPRSMFGPATTSTSSVVPIVPSVSTPLTEEQRRKIAENRLKAMELRSKREAEERERIEKEKREEEIPPEAMEEFPTFDEDEIMAQFDDFE
The following text describes a protein:
Function:
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
Subcellular Localization:
Secreted.
Sequence:
MKFTAISVVLVLLVIKNSSVQGILETNDANHKCKCLKTFGGALLLQYIKTIYISPPSGGCRNTEFIVTLKNGDKICVDPKCKWLSQVLRTLRRKKATTSNTNVQRQRQDSK
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MSNEKASTKAPKFAYPSKKKYCIFCSEKIDYIDYKNVERLKRFMTEKGKIIPRRISGNCARHQRQLSTAIKRARYMALLPYVVK
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MAPPAADAATTTEQEQHAAEGEGVVEVGGDLRLVAECGTEVRLSRSAARMSTMLLGMIEAGCADGGIPINGADVGTLRLVAAYCEKHAPHYDPVASAARLRDPFPPFPIEFTPPTYAIKPVTHPDPDPHGLEAWDHKFISDFRDNSALFNLIIVANLMAIEDLIDLGCTAVADKIRGKTPDEIRVALDIENDYTPEQEAEVRRENAWAFED
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDPMESSGEEKCVEESHKLVDSLDNLRVSAGSSSSSFKKKPVIIIVVGMAGSGKTSFLHRLVCHTFDSIMRGYVLNLVPAVMSLPFGANIDIRDTVRYKEVKMTFITHVCGSLLDYVLVDTPGQIEIFTWSASGAIITEAFASTFPTVTRLPLVLAFNKTDGADHKFALEWMEDFEFYRNIRSVGVSAITGAGMDDFFKAIEASSMLMICVFLFFRADLDKRKVEKEQLEEERREKEMEKLRKDIESSQGRTVVLNTGLKDRDGAEKMMLEG
The following text describes a protein:
Function:
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRKKVDARIRTLIENCAKTRQRALLVLVGDKGRDQVVNLHYMLSKASVKARPSVLWCYKKELHLSSHKKKRMKQIKKLAQRGLLDPEKEDPFALFVASTNIRYCYYHETQNILGNTYGMAVLQDFEALTPNLLARSIETVEGGGLVVLLLSNLNSLTQLYSMTMDAHSRFRTESHQDVVGRFNERMVLSLASCANCLLLDDELNVLPTSSLIRYIEPLPTNPDGTVVDDPARSARQELGELSGSLADTQPAGALVGRCRTLDQARAVVTFLDAASEKTLRSTVALTASRGRGKSAALGLAIAGALALGYSNIFVTAPSPENLRTLFEFVFKGLDSLDYKEHIDYDLVESTNPSFGKAVVRVNVFRNHRQTVQYIQPQHHAKLAQAELLVIDEAAAIPLPVVKQLLGPYLVFLCSTVNGYEGTGRSLSLKLIQQLREQGAKISAGDNKAGSKAAGGADGTAAPIANGTSGRTFREVHLGEPIRYAPGDPIESWLHELLCLDAGSHMPKPPPRLPHPSDCELFFVERDTLFSYHKASEKFLQQMVALFVASHYKNTPNDLLLMSDAPAHQLFVLLAPVDQTANTMPNILAVAQVALEGSISKRSAVNSLAKGELPQGDLIPWTVSQQFQDADFPALSGGRVVRIAVHPELGRAGYGSRVLEQLRRYYQGELTSLDEEDDAGGRGGAGAGGSGSGEEDGDEARRRSGADAAANADGDAPLLSERLAPRKGLPPLLVPLSDRKPDRLHYLGVSYGLTQQLFTFWRKAGYQPLYLRQSASDTTGEHTCVMVRPLEHPEVEGTAWLSPFVSDFKGRFTSLLGGAFREMAPALALSILDPQLNWGEEEAQRATQAGVVVHRGDGSGLDPYDLKRLQAYCSSLVDYHLVLDLVPPLAAAYLRGRVPVSLSYGQAAIMLVLGLQLREVSALEESLGLPSNQVLALFNKAMRKIYGCLRASKEAAVARTLPAVKPLAPGALTPHAVSLDQDLDEAAEAERAKLRERYLQPEDLAAFAIRGGEDDFASALGGKAPAAGGLVSVKGSGEGGGGGGGKKEGKQDMLYKKKDKGDKAERIGGGKGGLKKNKYGAMPGEGRSAKKQKQ
The following text describes a protein:
Function:
Antimicrobial peptide with strong activity against the fungi B.cinerea (MIC=5 uM) and C.albicans (MIC=33 uM), and no activity against the Gram-negative bacterium E.coli (MIC>200 uM) and the Gram-positive bacterium S.aureus (MIC>200 uM). Shows cytolytic activity against insect cell lines. Has no hemolytic activity against human erythrocytes. In vivo, peptide injection in the vicinity of the head and thorax of lepidopteran larvae induces feeding disorder that lasts one or two days before recovering.
Subcellular Localization:
Secreted. Target cell membrane. Note=Has an amphipathic alpha-helical conformation.
Sequence:
MTKQSIVIVLFAAIAMMACLQRVTAEPAPEPIAAPIAEPYANPEAIASPEAKDLHTVVSAILQALGKK
The following text describes a protein:
Function:
Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart.
Subcellular Localization:
Nucleus.
Sequence:
MEFTASPKPQLSSRANAFSIAALMSSGGPKEKEAAENTIKPLEQFVEKSSCAQPLGELTSLDAHAEFGGGGGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERE
The following text describes a protein:
Function:
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.
Subcellular Localization:
Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm.
Domain:
RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence:
MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYWLQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVSANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAVSVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMPPLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNTSLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFCAWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENEGRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRKNKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEARAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDLDIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCKMHEEQKDGRLSLFDWLLELG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Component of a med15-hrp1 subcomplex, linking the Mediator complex to the chromatin-remodeling activity of hrp1 at a distinct subset of hrp1-bound gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MNRNVDKGWQAQIRPNERQSIALQIAQTLRIISPSISEVQLMNMALSFERQAFDGASSKNEYLTTCGKKTAQLRDQIRDTLQATQMKQMPSVYNNAGNVGALPTAGPNRLANNPRVMPRLQNQNVPMQAGMQQFARNMKLTPQQRQFLLQQSQIQQQRQQQQQQSQQPQQTQQPQASSPTAPNTEANQQRSGSVPGRIVPALTQQQLNNLCNQITALLARNGNPPIPMQKLQSMPPARLISIYQNQIQKFRSLQHMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKQAPQNAFFPNPQGNVGAQSLQSMSPQDQPSTQQQQPQRTAAPPNNPNVNATNNNRINIEMLNIPVPKQLFDQIPNLPPNVKIWRDVLELGQSQRLPPEQLKLIGMLYRKHLQIILQHRQQQLNKIQNARMNSQNAPNTNKLGNPQPDNTGNPQAFSQQAFAQQQQQQQQQLHRTSNPTSASVTSQNGQQPINTKLSANAAKTNYQSYLTNKARNATQPTQPPVSQVDYSNNLPPNLDTSSTFRSSASPPSAFTKAGNEALSVPLSGARNTAASRPTNLAAGNSSASIVQQLLECGGTMGQQKMTSRIRELTERVMHSLMRPVPLDLPHDQKVMIASLIKSAYPMFSRTNQLICLFYCLTGNEEATIQLIQMRHIFKLQLEGLQQGVFTCAPQTLAKIKEKTSRYFAFVKAQLLRLHHEVNNNNMSIQNALAHISSLRTASINQQQQPQPQSQQQQQASQFPQAPSVSSNVRPINGSIPNAQPSVPGQAQPAAKANSVGNTSFPVDSKLAFQSLDVSQPDLQAKQKIASQVMKHGLKPEDLKLPPSKKKKIENLSTVQKPKDSVVNTPDVIMSSVDEIPSSVSPGTIAKEEGMAKAREEAIANPLKYAIDAFVAVDHEEEVSAIKSSQTPSSILKTPQSFFIPPSTPDLSFTDNKNSLSPSNILSLDGKFSFNDDSELWADLGNEINSEIGFLKEPDTMNLALDADKDKTKMQNKLTQINFDESCFLDPAIDDKDPWNEMLHEKKVLLKQLQVGNEDEDNIAFPTSTNIWQVVI
The following text describes a protein:
Function:
Acts a component of the ESCRT-III complex required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). The sequential action of ESCRT-0, -I, and -II together with the ordered assembly of ESCRT-III links membrane invagination to cargo sorting. Membrane scission in the neck of the growing vesicle releases mature, cargo-laden ILVs into the lumen. ESCRT-III is critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. SNF7 is the most abundant ESCRT-III subunit which forms membrane-sculpting filaments with 30 Angstrom periodicity and a exposed cationic membrane-binding surface. Its activation requires a prominent conformational rearrangement to expose protein-membrane and protein-protein interfaces. SNF7 filaments then form spirals that could function as spiral springs. The elastic expansion of compressed SNF7 spirals generates an area difference between the two sides of the membrane and thus curvature which could be the origin of membrane deformation leading eventually to fission. SNF7 recruits BRO1, which in turn recruits DOA4, which deubiquitinates cargos before their enclosure within MVB vesicles. ESCRT-III is also recruited to the nuclear envelope (NE) by integral INM proteins to surveil and clear defective nuclear pore complex (NPC) assembly intermediates to ensure the fidelity of NPC assembly.
Miscellaneous:
MISCELLANEOUS: Present with 3270 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus envelope.
Domain:
The N-terminus (residues 1 to 11) forms an amphipathic helix which is required for the association to membrane.
Sequence:
MWSSLFGWTSSNAKNKESPTKAIVRLREHINLLSKKQSHLRTQITNQENEARIFLTKGNKVMAKNALKKKKTIEQLLSKVEGTMESMEQQLFSIESANLNLETMRAMQEGAKAMKTIHSGLDIDKVDETMDEIREQVELGDEISDAISRPLITGANEVDEDELDEELDMLAQENANQETSKIVNNNVNAAPISENKVSLPSVPSNKIKQSENSVKDGEEEEDEEDEDEKALRELQAEMGL
The following text describes a protein:
Function:
Required for normal plant growth. May be both photoprotective and play an ancillary role in photosynthesis. May structurally stabilize thylakoids during osmotic and oxidative stress.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MASISSLNQIPCKTLQITSQYSKPTSKISTLPISSTNFPSKTELHRSISVKEFTNPKPKFTAQATNYDKEDEWGPEVEQIRPGGVAVVEEEPPKEPSEIELLKKQLADSLYGTNRGLSASSETRAEIVELITQLESKNPNPAPTEALTLLNGKWILAYTSFSGLFPLLSRGNLPLVRVEEISQTIDSESFTVQNSVVFAGPLATTSISTNAKFEVRSPKRVQIKFEEGIIGTPQLTDSIVLPENVEFLGQKIDLSPFKGLITSVQDTASSVAKSISSQPPIKFPITNNNAQSWLLTTYLDDELRISRGDAGSVFVLIKEGSPLLKP
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing all nonvolatile repulsive chemicals, including tastants, pheromones, and especially N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Also functions as a pheromone receptor for a male inhibitory pheromone leading to male-male courtship suppression.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIQIMNWFSMVIGLIPLNRQQSETNFILDYAMMCIVPIFYVACYLLINLSHIIGLCLLDSCNSVCKLSSHLFMHLGAFLYLTITLLSLYRRKEFFQQFDARLNDIDAVIQKCQRVAEMDKVKVTAVKHSVAYHFTWLFLFCVFTFALYYDVRSLYLTFGNLAFIPFMVSSFPYLAGSIIQGEFIYHVSVISQRFEQINMLLEKINQEARHRHAPLTVFDIESEGKKERKTVTPITVMDGRTTTGFGNENKFAGEMKRQEGQQKNDDDDLDTSNDEDEDDFDYDNATIAENTGNTSEANLPDLFKLHDKILALSVITNGEFGPQCVPYMAACFVVSIFGIFLETKVNFIVGGKSRLLDYMTYLYVIWSFTTMMVAYIVLRLCCNANNHSKQSAMIVHEIMQKKPAFMLSNDLFYNKMKSFTLQFLHWEGFFQFNGVGLFALDYTFIFSTVSAATSYLIVLLQFDMTAILRNEGLMS
The following text describes a protein:
Function:
Metalloendoprotease which cleaves peptides at the amino side of hydrophobic residues - such as the hormones Akh and Dh31, and the neuropeptides Allatostatins (AST1, AST2, AST3 and AST4), Crz, Drosulfakinins (DSK-I and DSK-II), Lk, sNPF and the tachykinin peptides TK-1, TK-2, TK-4 and TK-5. Functions in female fertility, memory formation and may also act in regulating insulin signaling and food intake. Likely to be involved in controlling feeding behavior and the expression of insulin-like peptides by cleaving various regulatory peptides that include certain Drosulfakinins, Allatostatins and tachykinin peptides. Required in females for normal patterns of egg laying and hatching. Required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle-term memories (MTM). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep3, in normal LTM formation; [Isoform A]: Cleaves angiotensin-1 and tachykinin neuropeptide substance P. Functions in maintaining muscle integrity, possibly independently of its endopeptidase activity.
Subcellular Localization:
[Isoform A]: Cell membrane; Single-pass type II membrane protein. Sarcoplasmic reticulum. Note=In larval muscles, localizes to both the cell surface and sarcoplasmic reticulum membranes that are continuous with the nuclear membrane; [Isoform B]: Cytoplasm.
Sequence:
MSRHSQLKLAMPSVHGAPATAPGSPMNAKARSVKLGLGVNQRTGRVQWCPGLTCCKMLLLLPVVMLPLTLVLILIMRLDGMLAALQLNEQRMRDLRNSHSEVPVYMEDYEALLPEGSTYNDLINEEFILPASKRTQLQILAAERARRCQPYRYGNGESMELEERNTLMKDSRTSFLPLGIPRECLGSGIELDIKPIDEEAYQRQKKRYQDIAPYWLEKIRIRERREAERHAEEASAEISEATAALQSFWNEEGTREGIRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MALVSPIPAMGERAGSMRFHGIGSPGSRSSRSGIMDEPVSRLIDEKIFVAVDKHVAKSKSTLIWALQNTGGKKICLIHVHQPSQMIPLMGAKFPVGAVKEEEVRVFREKEREKVHMILDDYLRICQQRGVRAEKMFIEMESIENGIVQLISELGIRKLVMGAAADRHYSRRMTDLKSRKAIFVRREAPTLCQIWFTCKGYLIHTREATMDDTESEYASPRPSISASDLLQTFSTPESEHQHISRVQSTDSVQQLVSNGSSTEQSGRVSDGSLNTDEEERESDGSEVTGSATVMSSGHSSPSSFPDGVDDSFNVKIRKATSEAHSSKQEAFAETLRRQKAEKNALDAIRRAKQSESAYSEELKRRKDTEIAVAKEKERFITIKNEQEVIMEELQSAMAQKAMLESQIAKSDGTMEKLNQKLDIAVKLLQKLRDEREELQTERDRALREAEELRSHAETSTLQLPQYFTDFSFSEIEEATNHFDSTLKIGEGGYGSIYVGLLRHTQVAIKMLNPNSSQGPVEYQQEVDVLSKMRHPNIITLIGACPEGWSLVYEYLPGGSLEDRLTCKDNSPPLSWQNRVRIATEICAALVFLHSNKAHSLVHGDLKPANILLDSNLVSKLSDFGTCSLLHPNGSKSVRTDVTGTVAYLDPEASSSGELTPKSDVYSFGIILLRLLTGRPALRISNEVKYALDNGTLNDLLDPLAGDWPFVQAEQLARLALRCCETVSENRPDLGTEVWRVLEPMRASSGGSSSFHLGRNEHRIAPPYFICPIFQEVMQDPHVAADGFTYEAEAIRAWLDSEHDTSPMTNVKLSHTSLIANHALRSAIQEWLQHHL
The following text describes a protein:
Function:
A flexible structure which links the flagellar filament to the drive apparatus in the basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MGFSQAVSGMNAASSNLDVIGNNIANSATSGFKAGSVSFADMFAGSQTGMGVKVAGITQDFNDGTATTTNRRLDLAISQNGFFRMQDSSGGIYYARNGQFKLDENRNIVNMQGLNLTGYPATGTPPTVQQGANPVPLSIPQDMISAKATTSGNMVANLTSTHDVIAEATSPFDPDNPDTYSFVNNMTTFDSLGNRHEINVFYVKRAEDATDGNTWDVYTRDSSAKVTDPADPTDPAAAAKRGSMVFDSNGALKNVTNGTNATSTTDFTFTIPMGVVNGAPAQSFALNVAGSKQQNTGADSIVAQNQTGYAAGEFTGFQINSDGSVVGTYSNQQTQLLGQIVMVNFSNPEGLSSEGDNVWKETQSSGNPTLGTAGSGGFGTLTSGALESSNVDLSKELVNMIVAQRNYQSNAQTIKTQDQILQTLVSLR
The following text describes a protein:
Function:
Specific inhibitor of cysteine proteinases. Probably involved in the regulation of endogenous processes and in defense against pests and pathogens.
Subcellular Localization:
Secreted.
Sequence:
MKNKSSLIILSVLVLLCGCYTELGLCGQDNFLKMKLGGVHDCKGSQNSAEIDSLARFAVQEHNKKENAILEFVRVLKAKEQVVAGKLYHLTVEATDAGNNKMYEVKVWVKPWMNFKQLQEFKHVEGGTSSDLGVKPDDHGSGWQPVPTNDLEVQDAANHAVKSIQKRSNSLSPYELVEILLAKAKVIEDYAKFNLLLKLRRGIKEENFKVEVIKNMEGKFHVNLMP
The following text describes a protein:
Function:
Involved in strigolactones biosynthesis by cleaving the C(27) 9-cis-10'-apo-beta-carotenal produced by CCD7. Produces the C(19) carlactone and a C(8) hydroxyaldehyde. Also shows lower activity with all-trans-10'-apo-beta-carotenal producing a C(9) dialdehyde and the C(18) 13-apo-beta-carotenone. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds. Also active on other carotenoid substrates like licopene or zeaxanthin.
Miscellaneous:
MISCELLANEOUS: The branching phenotypes of the max1, ccd7/max3 and ccd8/max4 mutants can be rescued by exogenous treatment with the synthetic strigolactone analogs GR24 and 4BD (Probable). The ccd8/max4 mutant also responds to carlactone (CL) and methyl carlactonoate (MeCLA), but not the lbo ccd8/max4 double mutant (Probable).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASLITTKAMMSHHHVLSSTRITTLYSDNSIGDQQIKTKPQVPHRLFARRIFGVTRAVINSAAPSPLPEKEKVEGERRCHVAWTSVQQENWEGELTVQGKIPTWLNGTYLRNGPGLWNIGDHDFRHLFDGYSTLVKLQFDGGRIFAAHRLLESDAYKAAKKHNRLCYREFSETPKSVIINKNPFSGIGEIVRLFSGESLTDNANTGVIKLGDGRVMCLTETQKGSILVDHETLETIGKFEYDDVLSDHMIQSAHPIVTETEMWTLIPDLVKPGYRVVRMEAGSNKREVVGRVRCRSGSWGPGWVHSFAVTENYVVIPEMPLRYSVKNLLRAEPTPLYKFEWCPQDGAFIHVMSKLTGEVVASVEVPAYVTFHFINAYEEDKNGDGKATVIIADCCEHNADTRILDMLRLDTLRSSHGHDVLPDARIGRFRIPLDGSKYGKLETAVEAEKHGRAMDMCSINPLYLGQKYRYVYACGAQRPCNFPNALSKVDIVEKKVKNWHEHGMIPSEPFFVPRPGATHEDDGVVISIVSEENGGSFAILLDGSSFEEIARAKFPYGLPYGLHGCWIPKD
The following text describes a protein:
Function:
The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRTLARSSLRFAPRATMAPTMAPLTMMRLNHTLIKGSIPDKYSNKYTLKFTEDHDWVAFHEDGVAFIGITKYAAEALGDATFVEVEEAGNEIEKDDAFGNVESVKATNDIIAPFDFEVVESNFDVADTPSLINKEPNGNGYLAKVKPIEGAEETEGLLTAEEYDEFLKNAH