lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.
Sequence:
MMREWALILSMLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLMGMQEAIEQAIKSQEILAISDPQTLAQVLTAGVQNSLNDPRLVISYEPSTLEAPKKAPALTNLTQEELLARLQEGIRYDILEGDVGYLRVDDIPGQEVVSKLGGFLVDNVWRKLMGTSALVLDLRHCTGGHVSGIPYIISYLHPGNTVLHVDTIYDRPSNTTTEIWTLPEVLGERYSADRDVVVLTSGHTGGVAEDIAYILKQMRRAIVVGERTVGGALDLQKLRIGQSDFFLTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALSILTLRRALPGVIQRLKEALQDYYTLVDRVPALLHHLASMDFSSVVSEDDLVAKLNAGLQAVSEDPRLLVWVVRSKETPPGLEAGADAPPEIAPAVPVDEAALQALVDAVFQVSVLPGNVGYLRFDSFADASVLGPLGPYIVRQVWEPLQDTEHLILDLRQNPGGPSSAVPLLLSYFQGPEPGPVRLFTTYDRRTNVTQEHFSRTDLLGQRYSTQRGVYLLTSHRTATAAEELAFLMQSLGWATLVGEITAGSLLHTCTVPLLETPEGGLALTVPVLTFIDNHGECWLGGGVVPDAIVLAEEALDRAQEVLEFHRNLGALVEGTGHLLEAHYARPEVVGQTGALLQAKLAQGAYRTAVDLESLASQLTADLQEMSGDHRLLVFHSPGELAAEEAPPPPPAVPSPEELSYLIEALFKTEVLPGQLGYLRFDAMAELETVRAIGPQLVQLVWQRLVDTAALIIDLRYNPGSYSTAVPLLCSYFFEAEPHQHLYSVFDRATSRVTEVWTVRQVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMALSATTGEAWDLAGVEPDITVPMSEALSTARDIVALRAKVPTVLQTAGKLVADNYASPELGAKVAAKLSRMQSRYARVTSEGALAEMLEADLQMLSGDPHLKTAHIPEDAKDRIPGIVPMQIPSPEAFEDLIKFSFHTNVLEDNIGYLRFDMFADNELLTQVSELLVEHVWKKIVHTDAMIVDMRFNIGGPTSSISALCSFFYDEGPPILLDKIYSRPNDSISELWTHSQLTGERYGSKKNVVILTSSVTAGAAEEFTYIMKRLGRAVVVGEVTSGGCQPPQTYHVDDTDLYLTIPTARSVGVADGSSWEGVGVVPHVAVPAEAALTRAKEMLQHTLLRARRSPGLQGCRDDLFQQSPGVGGTSGPYPKGIPACGPA
The following text describes a protein:
Function:
Plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages. May act in concert with other effector proteins to induce fusion of host cell membranes (By similarity).
Subcellular Localization:
Secreted. Host membrane. Note=Secreted via the bsa type III secretion system, and probably inserted into host membranes.
Sequence:
MSSGVQGGPAAHANAYQTHPLRDAASALGTLSPQAYVDVVSAAQRNFLERMSQLASEQCDAQPAAHDARLDDKPALRAPQERDAPPLGASDTGSRASGAAKLTELLGVLMSVISASSLDELKQRSDIWNQMSKAAQDNLSRLSDAFQRATDEAKAAADAAEQAAAAAKQAGADAKAADAAVDAAQKQYDDAVKQGLPDDRLQSLKAALEQARQQAGDAHGRADALQADATKKLDAASALATQARACEQQVDDAVNQATQQYGASASLRTPQSPRLSGAAELTAVLGKLQELISSGNVKELESKQKLFTEMQAKREAELQKKSDEYQAQVKKAEEMQKTMGCIGKIVGWVITAVSFAAAAFTGGASLALAAVGLALAVGDEISRATTGVSFMDKLMQPVMDAILKPLMEMISSLITKALVACGVDQQKAELAGAILGAVVTGVALVAAAFVGASAVKAVASKVIDAMAGQLTKLMDSAIGKMLVQLIEKFSEKSGLQALGSRTATAMTRMRRAIGVEAKEDGMLLANRFEKAGTVMNVGNQVSQAAGGIVVGVERAKAMGLLADVKEAMYDIKLLGDLLKQAVDAFAEHNRVLAQLMQQMSDAGEMQTSTGKLILRNARAV
The following text describes a protein:
Function:
May be involved in vacuolar sorting and osmoregulation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MRKRNKRSSEELKTDEAGSSSSNAEEASGAAAMPRLRSANRSSFVMLTIFALIMYASWSVYHYQFEVLPVPLSAEKAGKRGFSEIEAMKHVKELTDLGPHSVGSDALDVALEYVLLTAENIKNTSHGDVDVEVEMFYVKDGANLMNGGLFVGKTLIYADLNHIILRITPKYEPEAKENSILVSSHIDTVFSTGGAGDCSSCVSVMLELARGVSQWAHSFKSSVIFLFNTGEEEGLNGAHSFITQHPWSETVRVAIDLEAMGVGGKANIFQAGPHPWAIEKFALVAKYPSGHVMAQDLFSSGVIKSATDFQVYTEVAGLSGLDFAFSDNSAVYHTKNDKVELLRPGSLQHLGENMLAFLVYAASSSDLAKGNAFRAPEDTNQNSAIYFDILGKYMIVYRQQFANMLNNSVILQSLLIWLLSLVMGGYTAIVSFSLSCLSVILTWVLSLSFSILVAFVLSNITWAAVPYITSPWLVIGLFGFPSFLGAFAGQHLGFLLLQKYLSNAYAQGKRALSPSIQVNLASLEAERWLFKSGTIQWLVILVLAHYYKVGCSYVPLVWLVTPAFSYGLLEATLSPIRLPKPLKTATLLIALSVPLVVSIGSIIRIIGVLIGTAVRFDRNPGGAPEWLVNVIVSIVVAAAVCLTLVYLLSYIHLSGAKRSVILVSFVLFGLSLASIWSGLIPSYTEDTARAVNVVHVVDTMAGYGNSKDPISYVSLFSSTPGNLDREIEQIKEGFECGREKVVDFVTFSVNYGCLTYEETEMGWSDLDIPKIEVKSDRKTNERVTKLSIDTKDSTRWSIAINTNEIADFGFRVSGDPEELVPMSNKSSVGGWHVIQFSGGKNAPTKFDLILQWVENSTHASGNAGNDVQKYLIKLRTDIDRLTPKAERVLMKLPSWCSLFGKSTSPHKLAFLTGLPIDF
The following text describes a protein:
Function:
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein.
Sequence:
MISLDLAFVIQVINFLVLMIILNVFLFKPIRKVIADRKAQIDGSRERAAVVDKEVQEKMALYEARLRDVKAKAGAEREVLRKEAQQEESAILEKARKEAADSLASIKSRVAKETVDAKEFLKEQSRSLSLEICQKVLGRSL
The following text describes a protein:
Function:
Lectin with specificity for complex N-linked glycans and O-linked glycans. Has hemagglutinating activity towards rabbit erythrocytes that is inhibited by N-acetyl-D-galactosamine.
Sequence:
QKACTMDYFPVCCQIVLGGGAYTAGNPCSCQGFVASKGTCDNPYPCPCTTEAQFPVCCTTQWGLVSATGNCACGCMGGVPVSDGPCPEVY
The following text describes a protein:
Function:
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGSDKRVSRSERSGRYGSAFDRDDRDDRDSRSRRRDSEYKRYRDERNDQYDDYRDYESPERERMRDRERRNSDRSEDGYHSDGDYMDHDYRQDYYMDEKESKTIMLRGLPININENDIRELVESFEGPQPADVRLMKRKTGLSRGFAFVEFYHLQDATRWMEANQKKLVIQGKTIAMHYSNPRPKFEDWLCNKCGLYNFRRRLKCFRCGAAKAESDMEAPSGSSETPQSADYYSDSGYVSSAIILRNIGPHTVVDSILSALAPYVSLVVSNIRLIKDKQTQQNRGFAFVQLPSALEASQLLQILQTLHPPLKIDGKTIGVDFAKSARKDLVLPDGHRVSAFSVASTAIAAAQWSATQPAQQSGEAGDYAYLQQGQEGNSNFGQCSQDYQPFYQTQTAAVDQDTAPQSEGSPVPATTSAVVCQSPQMYQQPGSPTQSGTSTAASTTPASTTSTEEATTPTAIVPGVKYSVPDTSTYQYDESSGYYYDPQTGLYYDPNSQYYYNSLTQQYLYWDGEKQTYLPAADGTGQSGAQPNGANPGTSKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPLSSRDEERKESAAADAGFALFEKKQGALFERQFLPDMMMMMVNTEEEKPPNAKYRDRAAERREKYGIPEPPEPKRKRFDPTVVNYEQPTKDGIDNSNIGNKMLQAMGWKEGSGLGRKSQGITAPIQAQVRMRGAGLGAKGSSYGVNTSDSYKDAVKKAMFARFSEME
The following text describes a protein:
Function:
May function in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).
Miscellaneous:
MISCELLANEOUS: Present with 1470 molecules/cell in log phase SD medium.
Sequence:
MPTPMTPVKVGALACQRNSFLFDGFKTLVVSCEPTKNKKGEIEGYEIELQDTILFPEGGGQPSDSGFLKIVEGNRNSSKIEKILVSHVSRFGLHAKHHVNDYIEPGTTVEVAVDEQKRMDYMQQHTGQHLLSAILERNYKVDTVSWSMGGIITKKKPVLEPSDYFNYIELNRKLTLDEITNVSDEINQLIINFPQEIIVEERIGEETVDEVSTSKIPDDYDLSKGVLRTIHIGDIDSNPCCGTHLKCTSQIGSILILSNQSAVRGSNSRLYFMCGKRVSLYAKSVNKILLDSKNLLSCSETQISEKITRQTKQIQQLNKREQYWIKRLARTASEELMNTLKASGKKRAYFMEEEYGTLELLLQIHKEVSNFLKDDTEGYEIILCGYERQTNTGSLLILSESGEKIANLAANLGSILQNLKGGGGKKGGKWQGKITSISNAEFAALSDYLSHDFASC
The following text describes a protein:
Function:
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Domain:
The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
Sequence:
MAPLALMGVVLLLGVPHCLGEATPTPSLPPPTANDSDASPEGCQGSYRCQPGVLLPVWEPEDPSLGDKVARAVVYFVAMVYMFLGVSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPGATDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGNGDKKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAGDEEEDEDGPREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLAFSVTLFTVFAFVCIAVLLYRRRPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHIRGF
The following text describes a protein:
Function:
May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (By similarity).
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
Sequence:
MFPLLIVLSQLPRLTLAVPHCIRSLKDSEHAPEEVFASKEAANIFMHRRLLNNRFDLELFTPGDLERECYEEFCSYEEAREILGDDENTIKFWQTYSIKGPTTGSDVNKEKIDVMSLLTGLIVAGVFLVIFGLVGYYVCLTKCKRRPYPSSSANYTRTARYTPSIVFRSPEEAVLSPSTSSEDAGLPSYEQAVALTRKHSVSPPPPYPGPARGFRVFKKSMSLPSH
The following text describes a protein:
Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MVRYRMRSPSEGPHQGPGQDHEREEQGQGQGLSPERVEDYGRTHRGHHHHRHRRCSRKRLHRIHKRRRSCRRRRRHSCRHRRRHRRGCRRSRRRRRCRCRKCRRHHH
The following text describes a protein:
Function:
Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips. As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes.
Subcellular Localization:
Nucleus envelope. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side.
Domain:
The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to the SUN proteins.
Sequence:
MNESVPDSVEDNGNSVPANGLLVLPDNDHEEGGVGSPQRSNSVESPGGSVHSTRKGFGLKKWRRIKRDGPVRDEAAPVDDGSKLLKRGLAGLVNPPSKHVEFSSVEARQSSEGSVGSVNMVHHPGVANGFSPDIGCMFAVGQAFEKSEEHSGNTIGGKNVVGGKVVSGSQEKLWSDTIKRASEERGDIEKEKPCSSLDSDLRSSDFVFSTGSVSVGNHGEKDERLTMNYIGGFSNEGQVKEEVQTYSRSENGNKEDDGESKKNNNHWADKDALADSIRSFAVLQEVLWKEVQSFQELGKESVLLHSNTDELSSDQPSHQNCKEDNSTSSGSKALILKEKVKLLEHKLEEARAALEAKEARIQELENSKIESELECIFQRKIETEIEHLMLTRSLSSLQVLQETKKLHSLKEDPVSNRGNILGKTCKLGFYILTQLILLVSILRFLVLQFSPASRLVIPT
The following text describes a protein:
Function:
Could have a role in the budding of coatomer-coated and other species of coated vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Single-pass type I membrane protein.
Sequence:
MNKTNQLINICILVTLFLIGSSSALTLQVEPKSQECFYNFIESGKTSLLLYQVIRGGLLDINVKLTDPKGNTIFERLHFDTQMKGKQSFTAGESGAYKVCFNNEMSRFTAKVVTFTWASEEEGVKEVAKGDSITPMDQSVQKIERVLQSVIHEQKKLRYREQANRDTSESTNARVVWWTIAEVIVLVVMGVGQIWYLRKWFDNKSTGRV
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MVKSPKSSKKAAARAAKARETAETNAFLDSIFILISSDGEKFQTDGHCIRHSKVLMQASKSLETPDTPIQVEKVQGDTLNRVLEWCNNHRDDGKYVSQCGPSLRLPQWDFRWLKDLDNQELVDLINASNDLQMQQLMDYACKTVANMAKGKNPAQLRELFGILTDEEEAELALNEPGPSTA
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
ATKSPNFVKTHIALKPPVYGVKNDANKKEFAKEFVNSQQNSKVKEWDSSFYLADLGQVVRNLQLWTKHMPKIRPYYAMKCNPSQPVVQLLASLGVGFDCASKFEIETALKCGVKPEDILFAVPCKMSSHIEYACQTGVQVMTVDNADELHKIKRIHPTGKLLLRLNVKYCGNGIKMGDKFGVTMSEARELILLCKELELDLIGVCFHPGSGSNSFETIRDSLQRCRELYDFAKLIGNDFKIVDIGGGFVCGDNFIKISKQVNATIDRLFPPETGLTVIAEPGRFFVENAFAFVTSVHGKAIRGDSAKYYIGSGVFAAFCLKYFEKFIRIPESLSRQADKCKCYASTVYGPTGAGDDIVLCDSMLPEAQIDDWWLFDNMGAYSPLLSLGFNGYMVTKAGFFISQDTWNEIADKLNPNSPLFEQYQQLEKTDEEIISNDM
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPTTFEQKLAHLKREAEHYADYLSDEEVEDEVATKAHEEADFCNDYSMAVVVGGLPVVDEAKHGKLLNVVKKIFGQVGAVVDIHMPFGASGKTTGYAFVEYDQEAHANDAVRTINNFALDKRHTMLVNKYADIERFQQTPAEFVASKVDKFTEPKNLQTWLTDPARRDMFMPSMKLLEKKSLRADGVHDFFWSPTDPILAYWAPEGNNVPARVSLVELPSRREVRQKNLFNVSDCKLHWHPNGTFLCVKVTRHSKSKKTLYTNFELFRVHEQLVPVEMLEVKENIVAFAWEPKGTRFATVHGEGQQRLNVSFYDMDGGSKGAKEVTLLYTLADKACSHLYWSPLGNNIVLAGLGEINGQLEFWDANEQQSITVQEHFKCTHVEWDPSGRVVATAVCQPLDNSYYKFTMDNGYTLWTFQGKQLLEEKKDAFYQFLWRPRPRTLLSDDEYNHVVKNLKKFEKRFDQMDRLKERERLAAEKAERNRKENEFQELLEKRLATAAARRAEYVALLGGYDSEDESEYIVQSHTYDDVLEIKEEVMRK
The following text describes a protein:
Function:
Required for spore wall assembly and ascus formation. Involved in the formation and elongation of prospore membranes.
Subcellular Localization:
Cytoplasm. Prospore membrane; Peripheral membrane protein. Note=Punctate location throughout the cytosol in meiosis II cells and peripheral punctate structures in the spore.
Sequence:
MGKNHFLKDFSALPEDVLIENERGITLLGYPLFSPKILLPHVDPPQFQRLNTENGSLIALSKNTISNFIELYPIDLSTERTAGSSSSQMTKWFVLMDYKEKYDIDDQGWCYSWNFNNSRWKSKNGLVRRRVWVRLPTTSHGLD
The following text describes a protein:
Function:
Siroheme synthase involved in methionine biosynthesis.
Sequence:
MGREGVPLIASLNASNEVMLLVGTGGSGRVVSRLRGLLNTGAQCIVVQPSNSKLVAQLYREFAGEPLLRILDRAFALEDLTTLGRYEASNVVDRVFLTPGHSADEILQAHAVYRQCIKLRIPINTSQRPELSTFSLPSTYRDPKGSGLQVAVTTDGRGCVLANRIRREIVSKLPANISEVVSNMGRLRDCITTRDHAELLQTVDLESELETMGILPDEDQWASHRFNKLVQEFRMKESDQRLKRLRWLSQIMEYYPLSELADVSVDKLLDEQTGAACSGTTATTGAASVTGATEDTAAEPAEGVASDSSGARDLARSAAGSIALVGSGPGSLSMLTLGALSEIKSADLVLADKLVPQEVMNTIPAGTETFIARKFPGNAERAQEELAEKALAALREGKRVVRLKQGDPYIFGRGGEEYLLFKRHGFEPRVVPGISSALAATTVAHIPATQRDVAEQVLICTGTGRRGVLPPAPEFVAARTTIFLMALHRVGDLVQALLEQQWDPQVPAAIVERASCPDQRVTRTTLASVPEVVEQIGSRPPGLLIVGHAVTSLKGLGSEQAGALHYSVEEGYGDDIPTLLETLVPV
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular Localization:
Nucleus.
Sequence:
MTLDFPVIFLLPTNLGADELHELEEQIPTLTYDINEAEVILGNVHRKQRVLFELRKHKLVTEEISTTETDEPTSPSPKRRRFQTPGSVITEDSDTASDGDFHPLLTQSTQSTLKATPTNVKVVKLAWFTESLKAGTVLPIQDYTLYRGRKQQSKPAKPQQASPTKAANIIKRALADPKPSSHGSRPGSSHSTTSHGRRDHFITKAPALLHMTTSEHEVELPPIPAYLHTTYACQRPAPTHPPNEPFIEELMKIRTARTLLGDKIGVRAYSSAIAALISYPYPLQSAFEVARLPGCGLKIAQLYQEFREQGELQEAKEDESDPRLAVLKLFHEIWGVAETTAREFYNKGWRDLDDIVEYGWDTLTRVQQIGVKYYDEFQQKIARAEVESIANIILEHANKIHPGFQMVIVGGYRRGKLASGDVDVVLSHPDKAATRGFVEQIVVALEQSNYITHTLILSTANTERGQEPVAWKGNEKKSGTGFDTLDKALVVWQDPHWTTDEKKNPIPHRRVDIIISPWKTAGCAVLGWTSGTTFQRDLRRYCKKERSLKFDSSGIRSRADGTWVDFESGPNGEPAPDMLTAERRVFEGLGLEWRPPEERCTG
The following text describes a protein:
Function:
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation.
Subcellular Localization:
Nucleus.
Sequence:
MQSQRIPGRKRGRPSLHSTPMKMAVHNLYSASAGSLPAVKIPKKRGRKPGYKIKSRVLMTPLALSPPRSTPEPDLSSIPQDAATVPSLAAPQALTVCLYINKQANAGPYLERRKVQQLPEHFGPERPSAVLQQAVQACIDCAHQQKLVFALVKQGYGGEMVSVSASFDGKQHLRSLPVVNSVGYVLRFLAKLCRSLLCDDLFSHQPFPRGCSASEKVQEKEEGRMESAKTVTTEEYLVNPVGMNRYGMDPSASTFNHRGSLPPSSSLYCKRQNSGDSHLGGGPAATAGGPRTSPMSSGGPSAPGLRPAASSPKRNATSLEGNRCASSPSQDAQDARRPRSRNPSAWTVEDVVWFVKDADPQALGPHVELFRKHEIDGNALLLLKSDMVMKYLGLKLGPALKLCYHIDKLKQAKF
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSQDLIETTATTTKIVEARELGHQIHDSLLEQLKLQQEELLQQQRDLFFQEQQLQLQQQVTQPVSNNGNTWSFTQGLVIGQVSVIFIIIVFVKFFVFADSSSHIPTKPGLDGATGVIVKRNKNKKHSNGQFANDGENEDDTSLDSNQSKISSILEKTYYDVNNHASESLDWFNVLVAQTISQLRSEALLKDNIYHSLNNFLTNAKLPDFIDTINLTEIDIGDDFPIFSNCRIKYGEDLKRLEAKIDVDLSDTLTLGIATKLLLNQPRPLTAVLPVSLTVSIVRFSGCLTVSLINTKDIDLKNVDKTSNMNGYSKENANGDGASSSNNDEDEDDGGTALMFSFSPDYRLEFIVKSLIGSRAKLQDVPKISSLIENQLRTWFIERCVEPRFQVVRLPSLWPRTKNTREPVTKKTTTTPSTTVNGTSAATITTPGEYVNSNI
The following text describes a protein:
Function:
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.
Sequence:
MTRPPGASFAEFFPTAPKVKAQAQTRADQVRDRDRFKTASTPATINGTIDSTTGTAVLEADANVSLNGIVSASDTMPTQPDDTESPFTDIPNTVDSASSYSSAASSIFSTSTRHGAAATTASSRLPTSSLTPSAFKESPNSAPAAAKPDMSTYQTSDRAARQSSRNSPATGPNVSISNGLPSNERIPARDPLPSVKGLRCTYDPLLDRVHNKSVSKSAKPTYEEFGREDDAPPPKDPRLARSDGRLGYINTDYYLPKSRLRTAPENIKPYPYDPKTSIGPGPPTQIVVTRYNPLIPFSKVTAIFASFGEIAESSNKMHPETGSYLGFATIRYRDSKRPDRPPVSGIDAARRAVRARGIKVDADIVRVEYDAEGRRSRRMLEEHLKREKEKFEKIEQERLALAAKAPPTGPKSGTAPAFTRPPPTAPKGPSAQRQSIPTGTPQIPLLGTQVQGLNLEPSNLAQKLADDPYIYVTGDSVPVLPSILPHMKKRLKSYGFEEIRVDKSGYFIVFRNSFTGSSEAERCFRAVNHTEFFNYDMTMQLCLPRPRREDGSGRRRSSASSDRHTHAEPRYRDEKDRRRREEEADLEEEKKQRAKNFDPVIEAVEVVRREMMEHLIRHIRTKVAAPALSDFLDPANHAAKRRKLNIEHPDDLQEIPSIEDGNDSSRVGTPNSRADPIERRTGRLEPKALPRIRKTKVKGQAQKSAFVDPFARKRPPVARNAFRSLHHRLRSLDSDAESDDDTDTRALLARETEEADSRPRSRMSTDDEASKDDFVPWEQGEDDSMTEASFAIADTASTRKRKLVASLESVFKRQKKSDEELFGVNLETLDSEFKGREDSVDIIPEPETGDDVESRVSRSETPASAIGKPLKKRPGKRKKTKKASFEEPEAAKTQPETEQQPGDEATEPSKVKQEKAEKTSMEELVPEKFDEKLFATEPLTPALELPEGAKPDLPIFQGLTVSAQDIPDLAKLARRFNTKDIGNAELWLWTRNRIRELNSARRTLDSPVTIGGYYVPNPTGCARTEGVKKILNSEKSKYLPHHIKVQKARQEREARNKLGRDAAAEAADAARIAAEKLVAKGNSRANRATNRRYVADLNDQKKTLGQDSDVFKFNQLKKRKKPVKFARSAIHNWGLYAMENIAKDDMIIEYVGEQVRQQISEIRENRYLKSGIGSSYLFRIDDNTVIDATKKGGIARFINHSCMPNCTAKIIKVEGSKRIVIYALRDIALNEELTYDYKFEREIGSTDRIPCLCGTAACKGFLN
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKIESINKLLKWAESNGAQISPDVEFKEISKNYIGAIYKGNKVPDSPFCPISIPSKLIITPQTAFKEFSKSLKNTDINDNSILKLHLCHERLNGNSFFYPYLNLLPSLSEIDSPYTWSANDKSYLQGTNLGNSLKENLVTLVEEWWKAINALHDDLPKPEQHYINMKFYYEYKFYTDDDLNKYLNDENIENWTSFPNYLWASLILKSRSFPAYLIDKNNKQDSAMLLPVVDLLNHNSKSKVHWDVSDNYFKFSSESIVPGKEIFNNYGLKGNEELLLAYGFCIENNSQDSVALKIKMPEEKIKAIEEYGIKLPTIDDYTNSVVANDAPSTAETKHQDGVLFFINNENIPSNLIETFQFLVQNEWETGITLRMKLSGLNHLRAALETKKNLLKLDVPQDSQKHKYILWYIESQFKIFTSAIKSIKRMEKEILKDEKTHLTTLKNVFKKDCKFQQSMLFLGFADYDAVLESQFQDQCWLLWLIRCYNRDQYTNDSECLPMWIHDLFVKLRKNTDISAQEVLNYKPIYENLIPDLSVQIPEIYGKGQWTLSEFIIAAKLLDLVGFVRGKEQECILVEQTYS
The following text describes a protein:
Function:
Specifically methylates the N7 position of a guanine in 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MEESFKEILKEKVNELNLKLDPLQEEKFYLYYKALKEWNRKINLTSLEGEEEIILKHFVDSLACIIPIKDENIEKIIDIGTGAGFPGIPLKIYNEKYKLTLLESQKKKVLFLEEITKILKLSNVEIIWDRAENLGKNPKYRENFDLALARGVAKPHIVLEYAIPFVKIGGIFLGQATPNNITEWENTKRTIEILGGEIEEKLEVNFDNITRIFLKIRKKNNTPEKYPRRPGIPEKRPLIM
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MKERRVTNRGAPAAPAAAAASRRRKKPAFDPSGGFFSGVRIGAVAAFAIFVLTAITLVVLLSALYPRETPRSITPVALPKIMDLPQFQGEHKERLYWGTYRPHLYLGIRSRTPKSLLAGLMWLGIKDGYYALRHTCEDSDGLKRYGWVRHDGISYGRQVILDQNMNITTFFSKSWNDGSGYGGDWSVRVNLHHSRFWFFLKKTKSSLYFYIAEEEGSQIRISRNDASGLAASGHRHDIGHWQIHISAENNTFFHYAGFRTGNMHNITQLVQNSLIVQERKLQLPDTYEKSSNIVVFQVLGRNHLQLDVTFLAGVDEKKFSVQSRLDRLSGIRLDETLRVQEQIFDKRFENAYKLDNEELSSFGATNAVEIGKAALSNLLGGISYFYGQSLISIPSKEQKHHRESFWKYWPAALYSAVPCRSFFPRGFLWDEGFHQIIISRWDRNLTYDIVGHWLDLLNVDGWIPREQILGEEARVRVPDEYILQHTDNANPPTLFLPLHGLKAYIALASLESGKENNAERAFLEKSFPRLQAWFGWFNRTQAGTFPGTYYWHGRSITDKELNAKSLSSGLDDYPRASHPSADERHVDLRCWMALAAKSMVMIAKIIGAPHEVRKNWHSMARSNDLLFQKYEAMSQVLSDFDVLNQVSLHYDRKRGRYYDYGNHTEKVKLEWDNFFDPRTGQVQQVLRRVVSGRPKLQLVPQFGYVSLFPFIVKLIPADSQILEAHLNLIQSEKLLWTSFGLRSLATTSSIYNRRNTEHDAPYWRGPVWINMNYLVLSSLHYYSQEPGPYKDAAASVYKQLRANLISNVARRYNEMGYIFEQYDHTKEGEGKGARPFTGWSSLILLIMAEQYQR
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MALQSTLGAVWLGLLLNSLWKVAESKDQVFQPSTVASSEGAVVEIFCNHSVSNAYNFFWYLHFPGCAPRLLVKGSKPSQQGRYNMTYERFSSSLLILQVREADAAVYYCAVE