lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor (RsaM, AC L7N5D7) until released by regulated intramembrane proteolysis (Probable). This sigma factor is required for the synthesis of surface or secreted molecules.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target; MISCELLANEOUS: Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning anti-sigma factor is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating SigM (Probable).
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core (By similarity).
Sequence:
MPPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSEDADDALQDAMLSAHRGAGSFRYDAAVSSWLHRIVVNACLDRLRRAKAHPTAPLEDVYPVADRTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTARMLGVAEGTVKSRCARARARLARLLGYLNTGVNIRR
The following text describes a protein:
Function:
Plays a role in the accumulation of some potyvirus during viral infection.
Sequence:
MQVEVMQIPNGGPAPILVKAEQPCSAARKSNLSDKDCVLKTVMGVLNEPTLKKFDLLNRQLIITGITSADILKGVVTLIFDKAVLEPTFCTMYAQLFSDLNAKLPPFPSDEPGGKEITFKRVLLNNCQEAFEGAANMREEARQMTSPEQESECKDKERLIKLRTLGNIRLIGELVKQKMVPEKVVHHIVQELLGQDPKSCPEEENVEAICQFFNSIGKQLDEKHKSRRINDVYFNRLKELSTNPQLAPRLRCMVLDVLDLRSNNWVLRWEEGKPKIITEIHTEAKTLELRSGAIASMRYSRGPLGPQGGLISSGYRRGTGGMTPGMLGVRKMLGMPEMDNDNWEGEPAPTLDKAEQPCSAARKSDLSEKDCVLKTVMGVLNEPTLKKFNLLNRQLIITGITSADILKGVVTLIFDKAVLEPTFCTMYAQLFSDLNAKLPPFPSDEPGGKEITFKRVILNNCQEAFEGAANLREEARQMTSLEQESERKDKERLIKLRTLGSIRLIGELVKQKMVPEKIVHHIVQELLGQDPKSCPEEENVEAICQFFNSIGKLLDEKHKLRRINDVYFNRLKELSTNLQLAPRLRCMVLDVLDLRSNNWVLRREEGKPKIITEIHTEAKTLKLRSGATASMRNSRGPQGGLISSGYRRGTGGMTPGMPGVRKMPGRTCSYTSQSRAAMFSSSKKRVLKTVMGGLNEPTLKKFDLLNRQLIITGITSADILKGVVTLIFDKAVLEPTFCTMYAQLFSDLNAKLPPFPSDEPGGKEITFKRVLLNNCQEAFEGAANLREEARQMTSLEQESERKDKERLIKLRTLGSIQLIGELVKQKMVPEKIVHHIVQELLGQDPKSCLEEENVEAICQFFNTIGKLLDEKQTSRRINDVYFHRLKELSTNPQLASRLRCMVLDVLDLRSNNWVPRWEEGKPKTITEIHTEAKTLGLRSGASASMRNSRGPLGPQGGLISGGYRRGTGGMTPGMPGVRKMPVMPGMDNDNWDVPRSWSMPRGNGPMVQPGGRGPPPLVVKSPSLNPRLLPQGSDGFVSAQGSGAPPAGK
The following text describes a protein:
Function:
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template.
Subcellular Localization:
Nucleus.
Sequence:
MSSENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGLFGM
The following text describes a protein:
Function:
Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAEPGEQRKFVLGRCCIFHWRGKASIIIPLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTALFPLVFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLMSVSTFMGLWISNSAGTAMMCPIVKALVNELDTNKIFPVYMTQEEEPVEEGEPPHPSKITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVNVTLVIIAFLITHMGLFRPNSKTGKIIAEANTNRKLMEDVLRQRHIDLGPMSCHEIQMAIAFAFMIVLLITRKPGFVPGWSDLINRKVVGSASGLSFIVLLIFALPTQYTFFKYCCGKGPFTAQAIDAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQTKI
The following text describes a protein:
Function:
N-methyltransferase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product. The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD. 4-hydroxy-L-tryptophan is accepted as substrate by psiD as well. The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine. The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin. The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin. 4-hydroxy-6-methyl-l-tryptophancan also be converted the decarboxylase PsiD, kinase PsiK, and methyltransferase PsiM into respectively 6-methyl-norbaeocystin, 6-methylbaeocystin, and 6-methylpsilocybin.
Domain:
The conserved NPPF motif is required for catalysis and represent the basis of substrate specificity toward norbaeocystin; Residue Asn-247 is essential to allow enough space in the active site for multiple methylations while also participating in a network of hydrogen bonds that stabilizes secondary structure elements in the immediate vicinity of the active site for optimal methylation of norbaeocystin.
Sequence:
MHIRNPYRTPIDYQALSEAFPPLKPFVSVNADGTSSVDLTIPEAQRAFTAALLHRDFGLTMTIPEDRLCPTVPNRLNYVLWIEDIFNYTNKTLGLSDDRPIKGVDIGTGASAIYPMLACARFKAWSMVGTEVERKCIDTARLNVVANNLQDRLSILETSIDGPILVPIFEATEEYEYEFTMCNPPFYDGAADMQTSDAAKGFGFGVGAPHSGTVIEMSTEGGESAFVAQMVRESLKLRTRCRWYTSNLGKLKSLKEIVGLLKELEISNYAINEYVQGSTRRYAVAWSFTDIQLPEELSRPSNPELSSLF
The following text describes a protein:
Function:
May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation.
Sequence:
MAADIGSQSSGSLEERFEQSLHLQNVDKQDWSLNSVLQFLKLYKFNKEWEDVFIKSRIEMDLFINLADQSKAEEFAFKNKLSKESAIQLSSCIRKTLLAPSSTRVPSKNSSYETLTYSAKDSSDDVFTETNSGFRSSNQNSSLKSFQSVPDSNVNVFGGFGGSVVDNNELLSTGKNSHQTTSLNLEGSPINLHAYKGTVTSIINDDSRNINKKTLSKQPVSEHKEKQTSFLRRFRVPGFSRDKDKTKDCPSSNSNPFHLASSNVKTLDASLDQGEWVPRIHRLESQIGLISKKKSFVLATMDDMKFTVVDITNVQNATQLRKLIAKSMYLDISIDQFDLFLTEVGGAQYIEILDDRKLDIARLYSDEFGTIKFFVKPSQNEESGMDSDTYLSFGTKSSSTYKADDDSIYHRKEDFKKQPSYPVLTSDFEITDAGPNLSLSGHQPDNKYYKGFSSAPNLAVVPELPSRRFRGFEKIRGAKGEMATKILDATEAQSEKNKFTVCRPHKKVTLKMPLNSGSSAPQSPSSNTSASVLTRNFVAHRDPPPPPTETSSLRRKNTLTRRPSIRHARSSPYIDTGHNEASKFSHTSFDPKASSKSSNSLKESVEALSEIPFEDAPALDESDLSGDPFWAIQPKQSSSQVPKENHHNIQSKLSINTEAATDLKANELSSPKTPEYCRGDDRSISLSPLSYRLRKSKHIRESPPSSKVINSGNWEVRPSADDLYEDVDRFFPRYDLDKVLVVDQSRMVSSPSKVSIRPKMKSVRLLAREASEARKEIRHNARRNKSGNLLRRSSTKLWGSRIVELKPDTTITSGSVVSQNATFKWMKGELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGPFEEQLVRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPFMKCDEEFNFKDTNLYDMLCKRKS
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Sequence:
MAGFRYFLTDGTRTVKYYYYRYGRKLLRLNYIRQAGESVLREKAAAVDPTAIVSTDVKKLIDRMIKTMRSHGDLGIAAPQLGRPLRIITLEITKRHLSYLQAQYRNVVQRDTVPLQVLINPQLKVLDNHKVAEYESCSSIHNCMAKVPRYTTVEVSALDRHGNRINYIADGWLSRILQHEVDHLDGLLYVDKMLSKTFAKV
The following text describes a protein:
Function:
Part of the osmoregulatory pathway which leads to the increase of intracellular cAMP concentration in response to hyperosmotic stress. Thought to negatively regulate the rdeA-regA pathway by acting as a phosphatase towards the HPt protein rdeA. Has probably no histidine kinase activity.
Sequence:
MSSPHIELHSQRTLSPQPSSNNFELTGNKSCALSASLNGSIDDLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDGDKNDKKLLIITNAPTPPLTPPQPTKTQQTLLELNQKFQEQQQQQQQQQQLQKQNKQQQSQKQQEEPPSSQQEEPPLSQQQQEQEQEQEQEQEQEEQSKQKIEGKGGGGEEEECEGGGGGEGEGEEQFKEGDEEEHEGIEIDPNLPTTGYTGKRRSSLQINEASPKLIQTPSVDRTLCILDSLPCPIFQIGIIENTENGNITLTGFANERLTTLLSCSSNLLVDSLKSIPSPHYNTVPSLESCNSIPINNLAPGLLPNTDPTKILDPYISLYNKKQLKERYSNNNNNTNTNNNNNNNNNNNNNNNNNNNNNNNDTTTTTTTTTTTTTTTTTTTTTTTTNESDNNNNNNNNNNNNNNNNNNNNNNNEEIKQNTKEGEEILHESTNSTGTGNSISRPNSILQCILDSFHEQKTITEKVLLSNFLIRQQYKSRATIKPFPDGCICIFEYIENINLNYQQPPTSLNDRINSTNKLTNEMELLSLSPDSNHQHVQKLHNHNHNHHNHNHNNTTQRASSTDSPFIHSVSANSLSSMSSNSSVTSACASLSSNSSSNSNNNSNNASSSNCSSNANSNNTNSSSSNCCCCCNNNNNNNTSSTSSTISSASSTKSKSYLHQQHKNSKVYSTLLNSFENLSFLLKSTPIIIWRADHNGEMVFFKKSDEIPIDEKKVVGNNFQDFLQWVPQTYRTNFQEMFQNSLKCGKIFEFLFWFQTPQNYVQLFKIAGYPIFHIDGKDCIASKRYLIGWLGVTYNYLINDGAEISIKGSANLDSMYEKFKIIYEMPNIERTKLTNNGISSGGDITNANNNGGSSESSNKILEKKKHLISEAEKECFLKCKETYNILFKLSLLGVMFSTFKGIILDANDMLLQTIGYTRGDLENGKIDWMLLTPPEHFEISARALQELKAKRWCQPIEKAYIHKSGKRVPVLITSAMIDGSTEQCITFVFDLSRYRQAEMAAIEATRLKTQFITNISHELRTPCHGIVGMSQLLLDSQLTNTQRDNIDSIKRSTDSLISLINDILDFSKLEYGKVTLENESFELLPMIEEVLDSQATAANRKGIDLIFVMGRDYPVPPVIFGDRNSLKKVLLNLVGNAVKFTETGFVLLEISTDYESGDQISLRFTVKDSGIGIPENKIEQIFVPFGQIDGSFSRKYGGSGLGLSFCKELVALMGGYIRVESGDQEGGKGTTFWFAIKVSISSPSYLPNSVPAANQFFYPEYRPSHYNNVIGNGDSPKNVLIIESNQMVIMSIQSILLSMKCECISASKAITALDLLESSKSTENQIDIIVCSDKSTFVQQILDYVTTEKVILYGVDPNSKYNENSKVYSYLVTPITHSKLISSILLSKNLKSKNSFLTTTNNTNNTNNTNNIENKSSIDSPLSITSTSSSIITPILTSNNLDLNNNNNNNNNSILVSNNGGVDGGNNVPSTLTTIQQSQPKKYILVAEDNDINIKVVVRQLEKLGYTAIVGINGLKALEIIGSFPICLILLDCQMPQMDGFTCSTILRQIEPTGQRIPIIAMTANDSKDRCFEVGMDDYLSKPVRVDRLQKTLSDWIKTDENGNPTNSYNFYPLSYSLVYNNFIDTQLKKEKNDD
The following text describes a protein:
Function:
Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.
Sequence:
MQSANETYLGLDLSTQKLKAVLLNANLENVAHAEVKFDSDLPEFRTTGGVNVGTAKNEFYVQPVMWIKALDMVLDRIVVQGADLSTVVALSGSAQQHGSLYWSRSGLDTLRHLDADKFLHTQLDDSAFTVHRTPIWMDGTTGRQCEEMEAAVGGRERMVEITGSRCYERFTGPQIRRIFQQRPDCYRNTERISLVSSFLASVFLGEVAPIDCSDGSGMNLLDVRTRDWSDECLAACAPDLRAKLGAPVPAATVIGPIGSFFVQRYNFNTGCRVVAFTGDNLSALAGMNVGKDWLALSLGTSDTVMMRLNAPSNLQEGHVLVHPTDDGFMGLLCFRNGSLVRDIFKRAEANDNWENFSELLDSTPRGNFGNLALHFLSKEILPPVKGSLRWNKNSSLASVELAKGVLKYSSPQSEIRALVEGQMLTRKTYATEMGFSFGESTKILATGGASANRSILQVVSDVFNAPVYTQKTTEAALVGAAYRAKYVLSVARSREAPCGDGKGAVSAPGPYYDFIAGLLPHSVTRVCDPSKDSEQIYGAMEERYRAMVSFMMEQQD
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MKGDVVPGLSDKQAFREELDELAQTIGLWAADYIDGVEKCQSTALLLKGTGQEKALELKELLRNLQEESGRIEAALGDQQETLKSYRKWIAQIKDREAAFGERISQLLEAKRRGEDKVSVAMAEISGKLDHRKNKLDALRKATSWYKELLGIRCEYSNAVKFIFTNIDPNNPEREFSFSIHHDKSANKFSMVDCSPHIDRSGPLLDSLNTSNELSQFVRSMRWEFVTLATGEPKV
The following text describes a protein:
Function:
Associated with membrane proliferation.
Sequence:
MSGNEFRFFLSCDINLPVTFRVERLEGNLPPAKSSDSDIDSASDERRAELFVECALYIDGAPFGLPTRTRLESSGPSYTWSELITLSTKYRDLTAHSQLALTVWDVSRGKEEELIGGATILLFNRKKQLKTGKQKLRLWLGREADGSFPTTTPGKVPRLERGELERLEKVVNKYERGQILHVDWLDRITFKALEEIREQESSKNGNSKLYLIVDFSGFEHRVVFQESGANFLLPSPIASTNEIVNVWDPEVGKFNPSEHKQLKLARSLTRGIIDKDLKPSSNERKSIQMILKYPPTRSLSGDERQLLWKFRFSLMSEKRALTKFLRCVEWSDIQEAKQALELMHKWETIDVCDALELLSPVFESEEVRAYAVSVLERADDEELQCYLLQLVQALRFERSDKSRLSHFLVQRALRNIELASFLRWYVAVELHDPAYAKRFYCTYEILEENMMKLTAGVNGDEDGFKLWHGLVRQTELTAQLCSIMKDVRNVRGNTQKKTEKLRQLLSGLLSELTYFDEPIRSPLAPGVLIVGIVPAESSIFKSALHPLRLTFRTENGESCKIIFKKGDDIRQDQLVVQMVWLMDRLLKLENLDLYLTPYKVLATGQDEGMLEFIPSRSLAQILSEHRSIISYLQKFHPDEHGPFGITATCLETFIKSCAGYSVITYILGIGDRHLDNLLLRDDGRLFHVDFGFILGKDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSNIPDIASDPEKGILKLQEKFRLDLDDEACVHFFQGLINESVSALFPQMVETIHRWAQYWR
The following text describes a protein:
Function:
Required for Fe(2+) ion low affinity uptake (By similarity). Has a role in zinc uptake under conditions of zinc limitation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes to the cell tip and barrier septum.
Sequence:
MTASITEIDSISEESNVESVSHLQHSPSFEKKGADFSISLNEKKDFASPITEEIPSPDGIATPEPETKKKLSFGARVWDLICSPGRQHDVCVAAPTQLVRSCDDYANSASTLVTNDDGTKTKVDSDEKKHKHKNVRDYIRFKHVDIGGRIFDLITRLAGTSFTFILMLIILIVWAIVGGIYRAPDNWQIVMQDGSSIQCYVSDTLLMRQQQNQHIQVLTMISQLRSRLLTTSRLLGPVLNDKTKISSVNVALMKDDVGDAEKLPTENWFDFICNYVSFMVGSIIFLVVYWIGIFIWIGFGRMLGWSDEWQLYINTAVAVELTFTSVFLQNVRHRHMKYIDRCVTSIFRIDSVIEEELRRMMGDKEPNEEITIKMDKINLGERSIDYYADLIGSGVGVVVSTCVFVAWIAIGNVMHWDSNWWLIIGTYTGLVGFLDGFVLRNVYFRESSKEATEIQTLIDEDYALYQKLDLPLPHEHITNYKSTFGGSLSQWIGWLCALPISVLFSVFVILGLIIAAGSLRFNETAQLFCNTPTMIIEGALLIVLIEAHNIANLKRRIQFRQIHLRRLTILKMLAGDNYSTTSTV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
NLLQRLLEPFRTEGLKLLLDSFFLSFLYFPHTPSPFYSFFSPCFPPYTFPPLLSFLSLKVAFYKRTQILVADIWSVLEGKGDGCFSDISSVTIFADYRLPQVLVHLGSGDKLEVEIRGCSIWCCELICKRLLDLYKKKGKDIRDKINPVLLDYYLWDYARDHREDMAGIPFHRVRCIYY
The following text describes a protein:
Function:
Part of the ETF-acryloyl-CoA reductase complex involved in the pathway of L-alanine fermentation. The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for acryloyl-CoA reductase.
Subcellular Localization:
Cytoplasm.
Sequence:
MAFNSADINSFRDIWVFCEQREGKLINTDFELISEGRKLADERGSKLVGILLGHEVEEIAKELGGYGADKVIVCDHPELKFYTTDAYAKVLCDVVMEEKPEVILIGATNIGRDLGPRCAARLHTGLTADCTHLDIDMNKYVDFLSTSSTLDISSMTFPMEDTNLKMTRPAFGGHLMATIICPRFRPCMSTVRPGVMKKAEFSQEMAQACQVVTRHVNLSDEDLKTKVINIVKETKKIVDLIGAEIIVSVGRGISKDVQGGIALAEKLADAFGNGVVGGSRAVIDSGWLPADHQVGQTGKTVHPKVYVALGISGAIQHKAGMQDSELIIAVNKDETAPIFDCADYGITGDLFKIVPMMIDAIKEGKNA
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MLTHIHIKNFIVVESLSLDFDKGLTVLTGETGAGKSIIVDAVNLALGERADTAIIRKEADQCDISLCFDISNNSDAQAWLKAKDFADGFDCIVRRIIFPDGRSRSTINGHPCTQQLIREFAHFILQIHGQHQHQTLLKRERQQQWLDNFAHHHELLDKIRQDYFQWKNLQTELNQLNEQAKNRDHELSLLRYQFEELENANLQEGEWKTLSQQHQQLHNAQSLIEKLTQAITLTVQSDEISASRLLQQAIERVNEIKMEDSQLAAIKEMLNTAAIYLQEAGTELNHYCERLDLSAENLTLLETRLSLLYDLARKHHISPDDLIDMKKSLQKRIEKLENIEEQIQSLKQRRVEIQTNYEKTASELSASRKKAAKTLEKKITEKMQLLGMSNGQFMVRFEKAETEISPQGKEKVTFYVNTNPGQEFLPLQKIVSGGELSRISLALQVITAQKENTSALIFDEVDTGIGGKTAGIVGQLLRELGEKAQVLCITHLPQVAALGHHHLYVKKIIGKNSVSTAIEQLTQKERVEELARMLSGTKITQQTIAHAESLLCGDSV
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPCPQPDDPPPSDAVTAHGTHPSTTCVRCKTNPAITILRDSIYCQACALAVFYQKAKAGLEYARGAGLSKYVAAAKAASSAAGSPAESRQTFSSSTSTFPPAANGEATTKRRIKHVSNGSGNAEENVSANIAIAFSGGISSRALLRSATQYFRPATAFTNRDTRRRKARGQVVDSNNNDNDSGTASISSKSMRGASTAAGRFNEVGKIYVFYIDDSAVVPNGVDRTEQARRMVEEEGCADLHFVGLKLHDVFRADDDGGFQGVAWRSVDVDHQQVSASISDVSDPRQALKDLFSSLCPVDTPRTGAASARTRIEDLHRIFISTLLRRTAKQYDCAALLLGDTATRISIRLIEDLAKGAGHKIPVQGSDAAWIDDLLIVRPLKTHLLQEVVFYTSQLNLDPLQPEQPIVAPTVSTTGILASNSSTPAMDKSSIARLTETFILNLEKGVPSTVTTIGKTGSKLVLNGAPGFPTTTWTDVAHSTSAFRDVGPSVSLSSRLTHRMANVTLAETQCEPRIGSRGIKLAQLSANCVRWNSINGCALCAMPSQHPKARWWKRDITISSLAETAPRSRQTVETQATCQSSEQADWLELCNHLCYACLLVLSPAISSAHPAMLPSTVLHHIHRSTHHAGAQHPHHIASRPLADDHELPPEHKTNQAACATHNMPNPIPQPLKPSQIKAHISEFLIE
The following text describes a protein:
Function:
Seems to be required for the conversion of a precursor form of the large subunit of hydrogenlyase (HycE) into a mature form.
Sequence:
MSEKVVFSQLSRKFIDENDATPAEAQQVVYYSLAIGHHLGVIDCLEAALTCPWDEYLAWIATLEAGSEARRKMEGVPKYGEIVIDINHVPMLANAFDKARAAQTSQQQEWSTMLLSMLHDIHQENAIYLMVRRLRD
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSRATVELDFFGMERQNQRKTLRRIQSAISKLNPQLLKTVIASGTSYVSLDGKPPENGTCRPTTPKENQNFVSTLPVVNPISPRAVSESPSPETAPLTIFYNGTVSVFDVPRDKAEKIMKLAEIGSTANCNAAVTADPKVVASSSTDEHELLESLNGGWLWCRLMGIHWNVRWTNKKNLAGGDSPDSQTPGVTW
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MRISHHVVHSVLVLFLVSCLLGSSLAAKLCSDDDKDGDNGCFRSRVLAAQRADLVKELPGQPPVKFRQYAGYVTVNETHGRALFYWFFEATHNPNKKPLLLWLNGDTVVIDTKGPGCSSVGFGASEELGPFFPQNSTQPNLKLNPYSWNKAANLLFLESPVGVGFSYSNTSRDISQLGDTVTASDSYNFLVNWFKRFPQYKSRDFYIAGESYAGHYVPQLSELIYNQNKIAPKKDFINLKGLMIGNALLDDETDQKGMIDYAYDHAVISDGLYQRVNEHCDFRLAHVSKECDGALDEYFDVYKILDMYSLYSPRCVPTTENSSVSHSIAGSRHLPAARGIFRPRLVSNNEGWRKMAAGYDPCASDYTEKYMNRRDVQEALHANVTNLSYPWTHCSDHISFWSDAPASMLPTLRTLVSAGLRVWVFSGDTDGRIPVTATRYSLKKLGLKTVQDWTPWYTNKQQVGGWTVEYDGLMFVTVRGAGHQVPTFKPREALQLVHHFLANKKLPTFPF
The following text describes a protein:
Function:
May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKHKVLDQLLMELHRFMVLLDRENLSGNATIQKGLLAELLQTYRTLNGADEEYIYMNKVVVGGNKDKDELSKLEVNGKAAKHVPVPQKSLPDLPPPRIGVVSREPFPLPAIPSPATVESYYEEAQPYEETANDWEYSGLASAPWMRGHSSDSVVYAVITRDDGEAVSSSYESYDEEEVTRGKSAQHQWPSSEASIELMKDARICAFLWRKKWLGQWGKQLCVIKEHRLLCYKSSKEQTPLLDVSLLGCSVIYKEKQLKRKEHKLKIMPVGGEAIVLGLQSKEQAEQWLKVIQEISPKPAEIWDPNQFSPDSSKLICTKGELGERHSLASESGSSTDSHADALENKDVKKKYGAGLMFSNLRNIGKKKNPSLESPEKCIETSGYLNVLVNSQWRPCWCLIKNRQLWCYQDKGKSKLSQPAVPLEGCSVLPDPNPEHLYSFRIDMDGTQLATLEAKTSADMGHWLGLLLSQTGTKTEPEDLTYDYVNSERISSIVNAAKTSLYLMLRRYSEPNTYIDTMPSISQNSEELYDDVASLADSEDTKENNPPNLQDGNLQECLQDSNSGKEAEDDRIYIDLLPVRSFLHPPGGAVPAKEPLSNSPVPVDNLTEPPCHIKEVVSVDLPEPASTSVLNGPTSPTAPSKLEQTLLQVTTSPQPHTQQGRNSPQSQELPRKSSLEIPKAFISSVADIHKGPSFLHSPQPARPKAHTIGSLCTFEVKLGKNRTEADMLRYTGERDRLEKEREEVKSCLAQLKKERREAKEELSGCQDPKEQALLEARVKEKEVACRGAESRRVEVELRLMEVKESLKKVEAGPFTLGTTLDSSLQDPPTVKITTSENVNSTKTSTMPSLPQPTSPPAPPPSSSSTTIFISITSPASAVNSASALKNRPASIVAPKGNVLQKAKEWEKKSTN
The following text describes a protein:
Function:
May be a regulator of keratinocyte proliferation or differentiation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDMRRSERLNAPADFMKAAEAASVCDPTPSLMTPAQFTGGPVVCSTSSQNTPAPFRATPASKFSVEGLGLTDTAAAEAWHLKHYNEKIIQQRSDHRLPEDERFSSRPPLQEVERLKEDREMMRGEMERLKGRVECLREQIRDQQSQINRQRIECDELRGELKSCKTELSMSKDQLLNLKGEYEVEYQRLEKKLQDSKQEIGKLQQKLDTQNMMTDTVQEVTSLKTQLQEVISERDELRNQLSVLNSSLLEQSESVQKLRTYIGSNIPEKKEEEELRRQIQHLEKEKEAMSLSVQLLNVRVNAANDILAIQEKELGEQVQMDPLCSGSKAGQMLSVWRQKVFVLLVKLQTQDLQLHTEKTQLHDMVSSLQQEVESLQSQNSVLQHHIEDKSARLELQHVHTQGIQQQLESVLLENIQLKERNKSSEASLNHISETAHRVMSAVELKAGQMEAVQSSVSQLNHRLAFAAKRLDTVHGLLLRKEALWRTKQATRCPEPAVLESFINSLKAEVEMLSTERDTLAQELKRTPELIQASLSELQQQRDRDLSHLREALSHSREELEASESSRMETLRHCEEQEGTIAELRTEAQRLQQQCDSVLQRVSEVESVCAEKLRDVEAQLNTARREHTKAVVALRQVQRQVEREKEQMKEAERERTEHTHRQITHLQKQLKDKDKDCNLLLAVVQEQGLMNEYKRLRRSAKTETLKQTQPCKSESKNPTPESLLGALQALSAAVMGSSEEDDDEEGQAFTETQTPSCADMHKE
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNIETIKSVYFVGAGGIGMSALVRYFLSKGKVVAGYDRTPTPLTENLIAEGAQIHYEENVRLIPEACKDKESTLVVLTPAVPQEHEELVYFRNNGFEIQKRAQVLGTITHSSKGLCVAGTHGKTTTSTMTAHLFHQSHIECTAFLGGISKNYGTNLLLSQKSPYTVIEADEFDRSFHWLSPYMSVITATDPDHLDIYGTEKAYLESFEHYTTLIQPGGALIIRKGISLQPKVQAGVRVYTYSRDEGDFHAENIRIGNGEIFIDFVAPDTRINNIQLGVPVSINIENGVAAMALAHLNGVTDEEIRQGMNSFRGVDRRFDFKIKNDQVVFLSDYAHHPSEIKQSVLSIRELYKDKKITAIFQPHLYTRTRDFYQDFADSLSLLDEVILVDIYPARETPIPGVTSKLIYDNLRPGIEKSMCKKEEILNILKDKNIEVLITLGAGDIDNYVPEIKKELEKMKNEERRTKN
The following text describes a protein:
Function:
Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MSGPNRTYSFGEGDDSLAHPSSRTHAMHSQYDDVSPISDGARMNPMNGQGMDHGLASVLEDGRQGWGRSPEPSPSLLTGSSATPGMDNLGPGAVGGGISGIALSVANSHDRLSGVEALMGTDGQEANIPAERGLSTTGSDNPYVPEPPEHRYSYGSNIALGAAAAPAGQLTPGQSVSHLSSTNPSQRNLYDIPYQDVGGLNAGPYQRHSAYSSNDLPVDINPDEIVDDGDDGFVPAPNSGSGARKSQAIPAAAGGAAAGGVLGNLGGLFGGKSAADTSYGPVPGAGLEAGEKGRWVKPKPGGGNKKRGWIVGAILAFIIIGAIVGGAVGGTIGHRGNEEPSSASSASSSSTQTATEDTSVNGDLDKNSAEIKALMNNKNLHKVFPGIDYTPWGVQYPLCLKYPPSQNNVTRDMAVLTQLTNNVRLYGTDCNQTEMVLHAIDKLEIKDMKIWLGVWIDSNETTSRRQIDQLYKIIDDAKDISIFNGAIVGNEALYRAGSDKTSAQTTLINYMQEVKDHFKKKNIDLPVATSDLGDNWDATLVQAADVVMANVHPFFGGIPVDQAAAWTWRFWQDHNVALTKGTNKKQIISEVGWPSGGGNDCGQGANCPNDTAGAVAGVDELNKFMEDWVCQALDNGTDYFWFEAFDEPWKIVYNTGKENWEDKWGLMDSARNLKPGLKIPDCGGKTAT
The following text describes a protein:
Function:
Plays an important role in retinal cone photoreceptor survival. In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity).
Subcellular Localization:
Cell projection, cilium, photoreceptor outer segment.
Sequence:
MASLFSGRILIRNNSDQDELDTEAEVSRRLENRLVLLFFGAGACPQCQAFVPILKDFFVRLTDEFYVLRAAQLALVYVSQDSTEEQQDLFLKDMPKKWLFLPFEDDLRRDLGRQFSVERLPAVVVLKPDGDVLTRDGADEIQRLGTACFANWQEAAEVLDRNFQLPEDLEDQEPRSLTECLRRHKYRVEKAARGGRDPGGGGGEEGGAGGLF
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Sequence:
MNWRIDRGSGHHASVDTFSSLKTKRCESMRLSLLFCAAFLPAFAMSPFASADESSTSSLSAQLKETADNSSKRYPAEVLQTFQRGVEQVRATGIEESAKKVGDEAIDATLKGWDQNEVTLSDVWSEGPVILMWYRGGWCPYCNLQLRAMQKQLSAIEGAGAKLVVLTPEVPEKAKETAEANDLEMLVLHDRKSEVARKYGIVFDLPESILPVYRDKFQLAKRNDNGAMELPLAATYVIDTNGKITYAFVDADYKKRAEPADVVAAVKKLQYLNH