lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Bifunctional enzyme; part of the car gene cluster that mediates the biosynthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigments and leading to orange pigmentation. CarAR catalyzes the first step of the pathway by converting geranylgeranyl diphosphate to phytoene, as well as the later cyclization step that transforms the carB product lycopene into gamma-carotene. CarAR also converts part of gamma-carotene into beta-carotene. Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme carAR first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase carB then introduces 4 desaturations to lead to lycopene which is substrate of the carotene cyclase activity of carAR that leads to the production of gamma-carotene. CarB then performs a 5th desaturation reaction to yield torulene. Torulene is the substrate of the dioxidase carT that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase carD mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGWEYAQVHLKYTIPFGVVLAAVYRPLMSRLDVFKLVFLITVSFFWVVKGLEANSCRLLLFLPCMLILRGVLLRLTNADSPWDSYLIKNRIWTYPPGVVVGLTAWDIPAEELFFFVIQTFNTSLLYMILSKPTFHPIYLSKKTGWGKIAGQILFASAIIFGLVSVSSGGEGMYMGLILIWACPFLLFLWSISYQFIVNLPWTNTALPIALPTLYLWVVDTFALRRGTWSITSGTKYGVVLWDGLEIEEAVFFLLTNTLIVFGLIACDNNLAILDTFPEHFPRTKGVPSLLTIIRTLILPKEKYDEERIQGLVSAVALLRKKSRSFYLASGTFEGRLRIDLIRLYAFCRAADDLVDEAPSVDDSRASIEKLRKFLDLAYEENQEEPSQRLREYVTSSIPEMFHMALLQLPTYYLPKQPLDDLLKGFDTDLLFDRKSGAFPIETTEDLDIYGSRVAGTVAELCNHLILYHTPEAVPEDIQREVVASGQEMGIALQYVNIARDIKTDAEIDRVYLPLSWLKEAQLTPEDVIQQPHGPTIEALRHKLLDRAFEKYNMAKGAIDKLPSEGKGPIRVAVESYMEIGRVLREKGPTMKKGRATVPKMRRIRVAWSALNK
The following text describes a protein:
Function:
Protein phosphatase which dephosphorylates 'Ser-59' of translation factor eIF2alpha during the liver stage, thus enabling protein translation.
Sequence:
MNISKFFLIFIPLVLFKYPANNELINYNVILKYDVKDLFKRVLQEQNEDIKDDNDENDEGDEEDEYYSYLKNRGTNEFDKVKYKYAEYVRFSIFKSKNIYTHIFNELLVFLGAQYGTEEEIVVHVKLIDILSLLFTHYKDNLSKFGHILNSFQDRSKLMNSVENEFMNEFINERDNYIYDVKNAYNKSDNNDDEWIETVLNKKNMLYDKFLKEWRIDGSNFYSIHNKKKTYLPKKVFQNKQNYIPDFENMEHVDLVCKPISDSAIDEKSAEKYEDKELNINEQNEQSNSKKEQTGNDNVSETKMHKEESSDSSNKTDESNVCKSENKYIKKTNNNKKIKEERHGFIYKMRNDFFLSDASLNVISLINSITSNEENKIVKKLYTGLKKLKITTFDNLIRYTNIIGIFFSYDIFDELYLQIKLIKEYFGLIPRNNDELSIVSKSKNVSKIKVYGKYNITDDEMFVPPVCLSAYCKLRSVWMQNRDFNFKIEKYSSNSINFMTLGDIGRGFKKENSYDEEQMLKLIGFNELKSTSNAMKDWHASNNADFVINLGDNVPEVDELDYLKNFEWHKIMRELFTFRKQDEDEEKNDADSYSITKDNIQEFYKEVEKQMNNTNTDDKNQHNDISTTPINNYTDGNEGNNNSENNNGFREYINDNTKDYNIYKNETTEKEETYDSIPFFSIFGEKDYFYFPSEQIQEHYAKRIPGYFFPNNYYRINYDFVYNNKEKNGVQEKFKASFIFIDTWSLMIGFPIIRNYRSFREQFNWINKALLESAKESDWIFVVGHHPFISSGRRSDNYSFEELSFHNIIRNFFFYYNIDGYFSAHDNLMEYLNFGPLNLFVNGSSSRVLFDKSTILGRGYFGKMVGSIYPVTCYLLTTIHSALRPKGCDISKYSKWSNKYDIGFSAHKLSKDELVTEFINSRSGKPVSQKIVIKNKKDKRRKFYDLDGYTNDKIKQFENKIYEFSSKNPNFIKYKIEEFKENDKKLNIIMNNLKSEEEKDAFRSLMFLNNLIFGISSHISNISFDQLKLMCYLANKYRTFFNKKLIKFLGEELKIAVQKMEVKTTNETPHNSNEILNTNENESIQPNDPTMKVEQIMELIDTLGYKPDEFLEKYDAMTQEEKDALKEKLGNDVSLEDYLSKVKMYIHKKKLSAEELKEYEENEENIKIAEVPDESKEDDNTNSQPEDTIDQENKDDINDIINAPNEVHKNYKELVEKEKKLTENEHALLMLSSLKTYDEMKYSLNILSKKEVIKEEAHPYGLYYIEKHKTFFQVSLELCPDIKRIISNLGKVGTKLAFYDYINNLYNKIMDLKNSIDKIAIF
The following text describes a protein:
Function:
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export.
Subcellular Localization:
Nucleus speckle.
Sequence:
MATETVEFHKLKLAELKQECLACGLETKGIKQDLIHRLQAYLEEHAEEEANEEDVLGDETEEEETKPIELPVKEKEPPEKTVDVAVEKKVVKITSEIPQTERMQKRAEQILTLYVRVRKLTLSKEGKKAARAARFGISSVPTKGLSSDNKPMVNLDKLKETAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEVQVLDCVM
The following text describes a protein:
Function:
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MSKSYTLESANEERRRVYHEADVVVVGAGIFGCAISYALAQQGRSVLLLERWLKEPDRIVGELLQPGGVSALEKLGLAHCLEGIDSVVVKGYEVIYHGTPVSIPYPMNAGKAQEGGFMDAKNEKSKRPEGRSFHHGRFISQLRKACAGHPNITIIETEVTETITGGHNETQVLGVHSRTTNPSTGEKKADCYFGHLTIIADGYASKFRKQYINKTPIVKSKFYALELIDCPMPAPNHGIVVLSDFSPVLLYQIGTHETRALIDVPDNIPSASPAAGGVRNYIHNTVVPILPPQVQPCFLKALEDGKIPRSMPNSFLPPTTQTQKGVLLLGDAMNMRHPLTGGGMTVAFNDVVLLSSLLDPSKIPNLNDTAAISKAMKEFHWRRKNLSSIINILAQALYALFAADDPQLKALQKGCFYYFHKGGNCIEGPAGLLAGIIRQPLVLIYHFFAVAVLSIQILMGEVMGGLSGIWKAPWAVEQSIEVFWKACIVIFPFIWSEMRS
The following text describes a protein:
Function:
Probable oxidoreductase that may be involved in pollen tube growth.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MGSGKVTFVALLLCLSVGVIAEDPYLYFNWNVTYGTIAPLGVPQQGILINGQFPGPRINCTSNNNIVVNVFNNLDEPFLFTWNGVQHRKNSWQDGTPGTMCPIMPGQNFTYRFQVKDQIGSYSYFPTTALHRAAGGYGALNVHSRALIPVPFDNPADEYNVFVGDWYNKGHKTLKKILDGGRTIGRPDGIIINGKSAKVGEAKEPLFTMEAGKTYRYRFCNLGMRSSVNIRFQGHPMKLVELEGSHTVQNIYDSLDLHVGQCLSVLVTADQEPKDYYLVVSSRFLKQALSSVAIIRYANGKGPASPELPTPPPENTEGIAWSMNQFRSFRWNLTASAARPNPQGSYHYGQINITRTIKIFNSMSQVGGKLRYGLNGISHTNGETPLKLVEYFGATNKAFKYDLMADEAPADPSKLTIATNVKNATYRNFVEIIFENHEKTIRTYHLDGYSFFAVAVEPGRWSPEKRKNYNLVDGLSRNNIQVYPNSWAAIMLTFDNAGMWNLRSEMWEKTYLGEQLYFSVLSPSRSLRDEYNIPDNHPLCGIVKGLSMPAPYKA
The following text describes a protein:
Function:
Involved in a high affinity multicomponent binding-protein-dependent transport system for choline; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVLTRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYTGIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIGGGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS
The following text describes a protein:
Function:
May be a receptor for the CD200/OX2 cell surface glycoprotein.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSAPRLLISIIIMVSASSSSCMGGKQMTQNYSTIFAEGNISQPVLMDINAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTVERITWVSRPDQNSDLQIRPVDTTHDGYYRGIVVTPDGNFHRGYHLQVLVTPEVNLFQSRNITAVCKAVTGKPAAQISWIPEGSILATKQEYWGNGTVTVKSTCPWEGHKSTVTCHVSHLTGNKSLSVKLNSGLRTSGSPALSLLIILYVKLSLFVVILVTTGFVFFQRINHVRKVL
The following text describes a protein:
Function:
Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.
Subcellular Localization:
Secreted.
Sequence:
MEHKVICVLAVVLMLAFGSLAQAQAQAQAQEETCIMAPRERINCGFPGVTAQQCTERGCCFDDSVRGFPWCFHPMAIENTQEEECPF
The following text describes a protein:
Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQNELLDDPMDTGAPAAEAAAADEPLPPAHGIDREVTPKPAGNPDLMQQSLDNPAIPMHLIEKRDDRRESCDDGYSLTVNESAIDIESLACSYDSNAFFLRARFIARHCPILRADAYISLINYLKEHTTDITHYVAFFNELESELARKEFKNRQLNFQIPLRDQKWIEENGATWQSTTDQLQAEYKRHKDEGVKESTRRAMEDLFQHYMMAGKIDEAIRLYSRGIRDYCTQLKHSINMWINWMEVAICANDWGKLDTVTNTAYRSLKDADDAEKNSQQSQQAPPQRGENAPYMVERDPNAPIQTLTNRQLIETALAKCLAAQVLLKLRNKRYSQVVETILQIKTECLQSKWFVTSSDLGIYGMLSAMATMSRADLKLQVSGNGTFRKLLESEPQLIELLGSYTSSRFGRCFEIMRSVKPRLLLDPFISRNVDELFEKIRQKCVLQYLQPYSTIKMATMAEAVGMSSAELQLSLLELIEQKHVSLKIDQNEGIVRILDERDENAILKRVNVTCDRATQKAKSLLWKTTLAGANIHSISDKETRPKRKNQKESAKFDRNFGGIDVDEDPRGIAGPSGLSDDFNIAYDQQPQQQVQYLEDLGDI
The following text describes a protein:
Function:
Catalyzes the NAD(P)H-dependent reduction of pyridoxal to pyridoxine in vitro. Is not able to reduce 4-pyridoxate, and to oxidize pyridoxine or pyridoxamine. Has Kemp eliminase activity towards the non-physiological substrate 5-nitrobenzisoxazole, producing 4-nitro-2-cyanophenol; this activity is not considered to be physiologically relevant.
Sequence:
MSSNTFTLGTKSVNRLGYGAMQLAGPGVFGPPRDRHVAITVLREALALGVNHIDTSDFYGPHVTNQIIREALYPYSDDLTIVTKIGARRGEDASWLPAFSPAELQKAVHDNLRNLGLDVLDVVNLRVMMGDGHGPAEGSIEASLTVLAEMQQQGLVKHIGLSNVTPTQVAEARKIAEIVCVQNEYNIAHRADDAMIDALAHDGIAYVPFFPLGGFTPLQSSTLSDVAASLGATPMQVALAWLLQRSPNILLIPGTSSVAHLRENMAAEKLHLSEEVLSTLDGISRE
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MMFMQQFRNLLHPAMKGARNISILAGGGTMRGFPTRNPFNTATLYSSLPTMNIFGQMQQVRWKTYGNEYQPSNRKRKRKHGFLSRIRSVNGRRVLRDRRQKGRMYLSH
The following text describes a protein:
Function:
Transfers N-acetylgalactosamine onto carbohydrate substrates. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRHRYRVAAVLIIIVIICLLNYQIDKNLQKEHEEHKLALTNCMKSGRIFNSSVPETKDFGSSFTISFADIQKTHSWLYLPKFQNSMSSEILMIVASRTDSFARRNVLRKTWMNPENSEIIKDGRMKALFLVGMTDGDDSRMRKVVMEEARIYGDMVVVDLKDTYEELPFKSLTTLLYGTSKASEFKLIGKIDEDIMFFPDKILPLLEQNLIDPSSESIYGMLFAEGGYVYRDKEHRWFVPDSTYGCDMFPPYTGGLFYLVTQDAAKKILNATKHRIFIPIEDALINGILANDCKIPRIHLPEIYGDHHSLTDEDTRGVLAWHTGKNDQQFLDYFYRKLSESRLKKKILDEKNKHLFY
The following text describes a protein:
Function:
Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide. Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it. The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia. In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion matrix.
Sequence:
MEKLSGKDKELIRGSWESLGKNKVPHGVIMFSRLFELDPALLSLFNYNTNCGSTQDCLSSPEFLDHVTKVRSLSHKCIYRGNELVNTINLYLASQVMLVIDAAVNHLDDLHSLEDFLLNLGRKHQAVGVSTQSFAVVGESLLYMLQCSLGQAYTAALSQAWLNMYSIVVAAMSRGWAKNGEDKAD
The following text describes a protein:
Function:
Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MLWKLLLRSQSCRLCSFRKMRSPPKYRPFLACFTYTTDRQSSKENTRTVEKLYKCSVDIRKIRRLKGWVLLEDETYVEEIANILQELGADETAVANILERCPEAIVCRPTAVNTQRKLWQLVCKNEEELIKLIEQFPESFFTIKDQENQKLNVQFFQELGLKNVVISRLLTAASNVFHNPVEKNKQMVRILQESYLNVGGSEANMKVWLLKLLSQNPFILLNSPTAIKETLEFLQEQGFTSFEILQLLSKLKGFLFQLCPRSIQNSISFSKNAFKCTDHDLKQLVLKCPALLYYSVPVLEERMQGLLREGISIAQIRETPMVLELTPQIVQYRIRKLNSLGYRIKDGHLANLNGSKKEFEANFGKIQAKKVRPLFNPVAPLNVEE
The following text describes a protein:
Function:
Hydrolyzes glycerolphosphoglycerol, glycerophosphocholine and glycerophosphoethanolamine in vitro. May be involved in release of inorganic phosphate (Pi) from phospholipids during Pi starvation.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSLKAIHVSEVPSLDHFPENPSLICSSRKANNKFVVVGHRGHGMNMSQSPDLRFSALKENSILSFNAASKFPLDFIEFDVQVTRDGCPIIFHDDFIYSEEQGVVYEKRVTEVCLSEFMSYGPQRDTGKTGKPLLRKSKEGKIHKWSVATDDSFCTLQEAFEKVENPNLGFNIELKLDDNVFYSSDHLSRLLLPILQVVSDIGNDRTIIFSSFHPDAALLVRKLQTTYPVFFLTNGGTEMYHDTRRNSLEEAIKVCLEGGLQGIVSEVKGVFRNPALVNKIKESKLSLMTYGKLNNVAEAVYMQHLMGIEGVIVDHVEEITEAVREMMKPSNRDADGTKPKPNFSDRELSFLLKLIPELIQH
The following text describes a protein:
Function:
Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. May directly activate some type-A response regulators in response to cytokinins.
Subcellular Localization:
Nucleus.
Sequence:
MDQARISFFPDGLRVMIIDDDAKAVRRATATLSQLQYAVVATHSTASAGLRALSGDNVVEIQAILCDVHKVVSSGFDFRRVVESELRIPVIYLLSKMEEEDMVAGEDAEFLNHLLLTATYIVRKPLNPTVMARLWRVVAWRMYCLEERIQANVAANAGAGGEDDDDDDDVVIVEEPQVHFKVVRRTSGGSRKRQLTINVVDDGNRGSGSGGGGGGGADANPTRILQHITSNLQEFRTKHQKKDMAIERPLISSDSMFLKAILPTLKISPCNPLTLTGGIGSSSVAAEAFAGGSSSAAPLQIPVFQQQSTGNGNTVISFSNNASPMAMRAPTDNTMISFNNVSAAPVANAVISFSNISRSAAMQAPAARGQHLSGDVQQLDFPQQKLYFGPFSYQGPPPPSMHNHINLLPPTSSPVTCSMDKGKVPIIELPYGMPVDDFLVSQTTYGGAGPSIGATDAAAAAYPYTDAPSNNVATGCLMVPPMGPAFSITEPTVVAQGEGTGTGVDAGTSEKNAIVEAPNNPAPLMVLDQVAADAAMDVQEDIMFSLESLLGPDYDLLPMEDVSAPDTAAAGDAAGGSLDGEEGGMDIGWDLDLDDILVENVNDFAFLDNLAGSE
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MVVNYQHPIQCIRYVEKQTAGFRNLFLASAGSKIYTYAAETGRKLAIWPEAPNASHSTVVSVAPSSEGDEPSAKKRKVSPVPEQTAKGGQPEASTAWSTIPILTVSSDGNFLVAVTGEDKCLRVFEIEESGHLKQLSERHMPKRPSAITLVDDDKTILCGDKFGDVYSLPLIDTGKSSIAPKIHAKMKPNQPAATTLTVHSKRNLASLEQQLRHYSQNEKTAEEKPTSAFELHLILGHVSMLTDLVYVSVPVDATSGRQRPYIFTADRDEHIRVSRGPPQAHIIENYCLGHTSFVSSLCVPQWAPEYLVSGGGDNHLIVWRWNESRLVQKVPLLEEGTDSEVVVRRIWALSLTKAANSQENANVILVALDGSSKLLCFTLESDGSLKAQNSIQASGNVLDLTVPSENSSIVVSVDAVREAGSTQEWRTSPSSPSTLVEAFRLKPASEGPLDWERTSEAITAQINSEGTSDISADLDEKQKKELNDSLYSLGNLRKKNMGEDD
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Sequence:
MKAYAFGFPKIGEKREFKKALEDFWKGKITEEQFEEEMNKLRMYMVENYRKNVDVIPSNELSYYDFVLDTAVMVGAVPERFGEYRGLSTYFDMARGGKALEMTKFFNTNYHYLVPEIETEEFYLLENKPLEDYLFFKSKGIETAPWVIGPFTFLYLSKRNGEWIRRPNQMEKLLESLVSVYKEVFEKLVENGCKEILVNEPAFVCDLEKAHWDLILNVYRELSEFPLTVFTYYDSVSDYEACVSLPVKRLHFDFVSNEENLKNLEKHGFPEDKKLVAGVINGRQPWKVDLRKVASLVEKLGASAISNSCPLFHLPVTLELENNLPGGLKEKLAFAKEKLEELKMLKDFLEGKTFDLPNVSFEDFAVDLQAVERVRNLPEDSFRREKEYTERDRIQRERLNLPLFPTTTIGSFPQTPEVRKMRSKYRKGEISKEEYEAFIKEQIKKAIELQEEIGLDVLVHGEFERTDMVEFFAEKLNGIATTQNGWVLSYGSRCYRPPIIYGTVTRPEPMTLKEITYAQSLTEKPVKGMLTGPVTIMSWSYYREDIPEREIAYQIALAINEEVKDLEEAGIKIVQIDEPAFREKAPIKKSKWPEYFEWAINAFNLAANARPETQIHAHMCYSDFNEIIEYIHQLEFDVISIEASRSKGEIISAFENFKGWIKQIGVGVWDIHSPAVPSINEMREIVERVLRVLPKELIWINPDCGLKTRNWDEVIPSLRNMVALAKEMREKFES
The following text describes a protein:
Function:
Neurotoxin that causes irreversible rapid flaccid paralysis in blowflies and honeybees upon intrathoracic injection. Causes a quick and irreversible cytolytic effect (at 10 uM) indicating it possibly acts as a pore-forming peptide. Shows only weak effect on aphids (A.pisum) at high doses 24 hours post intrathoracic injection. In vitro, is not cytotoxic on the dipteran S2 Drosophila embryonic cell line.
Miscellaneous:
MISCELLANEOUS: Negative results: does not show effect on the activity of Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5, Shaker IR, Kv4.2/KCND2, Kv7.1/KCNQ1, Kv10.1/KCNH1, Kv11.1/KCNH2, C.elegans KQT-1 potassium channel, and sodium channels DmNav and BgNav.
Subcellular Localization:
Secreted. Target cell membrane.
Sequence:
LAMAMGDAVADAQARAMAAAYAIAGKEKEKLKQCFKDMTLAAIDYAKHKVEKHLFKCI
The following text describes a protein:
Function:
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (By similarity). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (By similarity). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis. Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate FYN as shown in vitro (By similarity). May palmitoylate CALHM3 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Postsynaptic density.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MRRGWKMALSGGLRCCRRVLSWVPVLVIVLVVLWSYYAYVFELCLVTVLSPAEKVIYLILYHAIFVFFAWTYWKSIFTLPQQPNQKFHLSYTDKERYKNEERPEVQKQMLVDMAKKLPVYTRTGSGAVRFCDRCHLIKPDRCHHCSVCAMCVLKMDHHCPWVNNCIGFSNYKFFLQFLAYSVLYCLYIATTVFSYFIKYWRGELPSVRSKFHVLFLLFVACMFFVSLVILFGYHCWLVSRNKTTLEAFCTPVFTSGPEKNGFNLGFIKNIQQVFGDNKKFWLIPIGSSPGDGHSFPMRSMNESQNPLLANEEPWEDNEDDSRDYPEGSSSLAVESET
The following text describes a protein:
Function:
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.
Subcellular Localization:
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Mitochondrion membrane; Single-pass type II membrane protein.
Sequence:
MEAISAVVQLAGGAVLTTLALAVFVMYTQPANIVHFFLRLNKWRTGCTTKYVKVGEQQFAYMERGRPSKNQPSLLFLHGFSDRKETYCEIIMHLPKHLHLIAVDLPGHGDTGIKAKADLTVEAYAAKLHQFISEVDLNHGPLHIVGHSMGGGLAGCYAATYPEKMWALTMICPGGVKVPENSVMFEKIFRGNKHVMIPETVEQAEEMFNICLYNKSLIPPKRVLQGYVDYSKPYIDFNKELFDAMLELGQDGLTPYLGKISTPTQVMWGRHDKALHIAGLDVIKREMSAPLQVDVIEDCGHTVGLEAPKKAATFLLNFRETVLNK
The following text describes a protein:
Function:
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MIIRTLRSQLRLPKPVYISPPCRYYSTDLEKLKKESDTTESDNSASATGVIDKTHNEVLLYYDHIYPFTTSRNVVKQYLSRFSLPWSTAYDNEKLKQKVWDLSSPLATTAKITEFVPLRRDSGAFVKFKYPPEVPATQFIEEIRENVERNEQERVNSNILTRLYHQIWRNVPKVYSVKGTPWIEDLRRFPSPKLSVKFEGDPLTEEELYVLFRRYGLINEIEPGATEAFIYFHSTRAAISAKHCITGMVLNGGKTTLHIQFVAIKRSNFLVSLISNHTKIAIPVLIALLATFAVLIFDPIREWFIEYKILHNRKSFDQFKESRWFKYLYIPYRTITGWVYSSYDYIDSQIQEVTGSSCSEEDDSSNGSNIVDGQSVRDLKNESNMFWIERYEKSKQLQLWIMENANTFIIVKGPQGSGKEEFVLEHSLGSDERLNKKVLVLECDQLGKARSDNNLINTTASQLGYFPVFTWTNTVSRFVDLGVQGLTGQKSGLSESKETQIKNMFSLATQAIRKITTNEYNKYVKSVERRNKRLKDDEKIEVLKEEQFLQQHPEAKPIIVLNKYSRRADVSSNDFIPPLVADWASGLVQNNTAHVIFLTADVGSLQLLNDALPNQVFKDISLSDASMSSSRQYVCDVLKVKDTSTLDECLEPLGGRMLDLQSFIRRIKSGESPQQAINEMISQAAELINTFFLNSHHKFGAGDSNWDPSQVWLIMKLLSECDTINYSELVKSPLFKVSKETLEILTTLEKYDLISLKRDKGVLDKISTGRPLFKAAFANIISDLRIWKLYETEYIGRLISLEAAKIQKLEEELEKIYKIGKVDGRIDYVSQKIEASNKKILDLEKQAADVASYTGKPDGKSFLGIKF
The following text describes a protein:
Function:
Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVETDLMSSHSSNWKEIFRTHSIAQTIQLEKFVSQQIEEKGRELQQNVCFNYQSFIEASENLSNIRNNLEKVLQNSYEFQSMVSLPKVDRVSKFLSDNESISQTSGDYFIFLQRFYAHAILFVMELFNKEQYLQSSKLLIFCLRILPADLPNDHQCHILVNRLESCKNYLNNRLKQAMTSSLSKVSVVTSWILLNQANISSGLDIFLQECEDQLLILNDAREFSLTFLNTLKLARDFPNEIRSYLEASKNFNIFKEKEILRNICLDECYLKAYFSAEDVKVTTPFETLQQFDGDNILQQWKLSFFSKISHSEKSFFSNATSLTTLYQILEGLLSELSEPQFKEFYELWNSILQNHFIISSRNIIDSLGLYVNKIKEKLQICFEIPPTNSFDPWSFQLKQQVLNELKQNILPACGMDDGFQRFWQSLASFDMVLDESLQVLKKLQTLHLSFTLGDIIPNYLTLADYLLNFVKTSFAQIYELVCSFVNNVAVMESSSEKQLRTSRCLKIVRLLKQFRHMDESVPFDDLIYKLQNILVRELTDFTTGIYINESKINLDVAACITGNFFGPSFALYNSLIMLIDKLEVLGFDIVSDKFKGLLTPNLFESLFILNLERLKAAKSMDHMKQNTFDMEFINYLSDFTNNPREVIDYQHFIELIDLHVQDEFSKEDFDTVRANVKECVPKLLSFFTVLLPRVKAQKVIT
The following text describes a protein:
Function:
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Active against both saturated and unsaturated long-chain fatty acyl-CoAs (By similarity). Protects cells against lipotoxicity (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKTLLKIFAWATLRMERGAKERNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDKTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTILWGLGVLIRYCFLLPLRIALAFTGIGLLVVGTTMVGYLPNGRFKEFLSKHVHLMCYRICVRALTAIITYHNRKNRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREKDEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHEDRSRS
The following text describes a protein:
Function:
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
Subcellular Localization:
Nucleus.
Sequence:
MSANMEEGKTDIDDMKSNLHRLRNELNSLWQSDEGLHDQMNSVIGALQELKLLQVQTALDELEISNQTSQANPNTSSMLEQRNHSSRRAAHNPEEALAQQCFNTRLTMEPSLFLTSSPAEIRHIPRTHGHRKIHRGSLSTSSSFSSQEDSTDSNSSSYAIDDPSDWTASLMNHSRNRQPLVLGDNVFADLVGNWLDLPEVGGQDSIEEENNSNFKNSNSESSSSTHSQHLSKKLSLTASIFKRVLRRVRPQHYQESQEMDVCKQPKVTCRKAKTDASKPFWGRTRGMKKKTTPIQQEGVACQGSEGLMDRWVEIVEKHPPVFDYNSAVWV