lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
6-methylsalicylic acid decarboxylase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. PatG catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol. The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAKIDVHHHFYPQAMREALERAGGDPSGWYIPPWTLDLDKEISRVLKVQTTILSVTAPGPGIETDPGKAAALARLCNEEAAAIRDAHPLQYGFFASVPSLFDTAAVLAEIEHAFTNLHADGVTLYTRYGAGHSYLGDERFRPIWAELSKRRAVVFIHPTHAVDTQLINSWMPQPMFDYPHETGRTAMDLLTRGVIRDYPGCKIILSHAGGTLPYLIHRAATMLPFMPRNLGMSREEIVEAARTFYFDTAISANPVTLKALLEFAKPGHVLFGSDFPNAPRGAITHFTSFLEGYDNMSEETRRLVEREAALELFPRLRGQSTRACL
The following text describes a protein:
Function:
Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane.
Sequence:
MGCIKKAQGCVQARHILVVAWFWAFANVYILRTNLSVAIVSMVKSNFSASAASECTGTQNNTPPAGWTEDGEFEWNEWYQGQVLSGYFYGYICTQIFGGWLETRLGGKIVCGTSQLLGGLFTLLTPVAARGGVYALLAIRILVGFVAGITYPTHHGMWGKWAPIYERSRLMSITMAGANFGTVIVLPLSGYLADTYGWESVFYVTGCIPILWFVFWVIFVYDSPSSHPRIDPEEAKYIESHIETREVKSPPVPWLKLARCVPLWAIVIGHTCSNWGFYTMLTNLPTYLKQILGFDIKANGFLSALPHLALMVFVMTGGFVTDYIRKHWVSTLTARRIMTFLGQIPPAIFFVLAGYVGCDRAAGVAMLALSVAFGGLAVPGFKLSHVELAPRFGGILYGITNTFGNIPGFVTPLVVGTLTNNNQTREAWQTVFWIGAGIYVFGGLVVLVFLRTDVQDWAKDPEEEKGANADGLPSDMNTASDLKLDNSSTRTSTTRL
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEKEEAKLVGFWASPFVLRARLALKIKGIPYEFVEEGNVKEIPTLLHASNVISEPFKIVEYLDATWKSVDSPLILSVDPYNRTVQRFWTTYVDDKILPYMKHILKGSTDNDEEEFHESMQVLESAFNNESQGKNFFSKDNIGYIDISLGSMLSWMKAILCCWMRRRHLCWRGGLNYSKLMKLSKE
The following text describes a protein:
Function:
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
Subcellular Localization:
Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Domain:
The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).
Sequence:
MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MNPLKRTSESSVQEDEGVHKQQKRECQDFTPRRYQLDLYEVATRQNTIAMLDTGAGKTMIAVMLIKHFGKISKTNNDRKLIIFLAPTVQLVTQQCEVIKSYTDFEVEHYHGAKGVDQWKAYNWQEQLAKYQVMVMTPQVLLDALRQAFLVLDMVSLMIFDECHHATGNHPYTRIMTEFYHRSEHKPNVFGMTASPVIRKGVSSDMDCENQLSELENILDSKIHTVLDREEIELCVPSAKEVNRYYEPRTVSFEDLSEELGILCSKYDGLIAQLYSRLTNQYKDADEITKESRRRLSNSLAKICYCLEDVGLLCASEATKICIERGHRKGWLKGGGDTTDQQSDANGPGLFAENSMLHMKFFEEALHIIDKRLQQQQGIDALLNSESGCVEAIKGGYISPKLHELIQIFLSFRVIERTMKKIGRLPYFRVSFLTGGSSSVDALTPKMQKDTLDSFRSGEVNLLFTTDVAEEGIHVPDCSCVVRFDLPKTTRSYVQSRGRARQKDSQYILMIEQGNVKQNDLISSLMRSKTLMAEIASNREPEDSHPSFFPIPTEEINEYHISTTGAKITTDSSISVLYQYCDKLPKDKYYTPRPTFQFSQYGDGYECTVTLPSSAMFQLLVGPKARNMQKAKQLVCLDACKRLHQLGALDDHLSPSAEELPLEILSKTSTCTSGTTKRKELHGTTKVLSMSGSWASDRSVTKLQGYTMNFICDQVGQKYSDFVLLIDANIAKEAATLDIDLYLHDKMVKASVSPCGSLELDAQQMEQAKLFQALLFNGLFGKLFTGSKASKTAREFILKKDNTFLWDKANMYLLLPVDPTLDSAKSVCINWSVIEVAATAVGLMRSIYSEDQQNLIDKLNPEKNGGDLIHLANKSCKADDLRNMVVLALHTGKIYTSLDVSDLCASSTFDGASDKKEAKFRTFAEYFEKKYSVFLHHPSQPLLVLKPTHNPHNLLSSKIRDEGNRVENKNRANSLVHMPPELLIPLDLPVDVLRVFYLFPSLMYRIESLMLASQLRSEIAYTGSDISSFLILEALTTLRCCEDFSMERLELLGDSVLKYAVSSHLFLTFPNKHEGQLSSRRQEIICNATLHKLGIESKIQGYIRDAAFDPRRWLAPGQLSIWPCPCECPVNSEVVTEDIHRIDDKSIIIGKACDKGHRWICSKTISDCVEALIGAYYVGGGLRAAFSVLKWLQIEIETEEDLIVKAMSSASVWNYLPKVDVVELLEAKIGYAFSVKGLLIEALTHPSQQESGATYCYQRLEFLGDAVLDILLTRHLFLSHKDIDEGELTDLRSASVNNENFAQVAVKYNLHHFLQHSSGLLQDQINEYVNGLEGSSMDRTSLLSSGPSRGPKVLGDIVESIAGAVLIDTKLDLDLVWGVFKPLLSPIVTPENLELPPFRELHEWCDKSGYFLGIKCENRGDNIMAILNLQLKDLLLARQGHGKNKVDAKAHAASLLLRDLEEKGLVIPKNASRTEQSDSPKHHSNLLDAMDTQNIAPPRQKELTVSSTVPGSVIDEPLVVKVKLSKGGPRISLYESCKKLQWPMPTFEYVKVKPSVCPSSDGSSQKAAPQGFAFSSIITLHIPNGDVISLTGDGRADKKSSQDSAALLMLYELQRRGRFQVQEV
The following text describes a protein:
Function:
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. Also able to mediate hydrolysis of diphosphate (m(7)GDP) to 7-methylguanosine and 2 inorganic phosphate with lower activity. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates.
Sequence:
MGFDEKREPTGGRLRLQDIPALTQDHCRMRDPAEVERIINEFVIGGPERMQIVSDFDYTITKQRTEDGGAVPSSFGIFNACQSLPENFKAETDKLYHKYRPIEIDPHMPIAEKVQYMIEWWTKSGELTSGFPFDQSEIDQIASKYTHALRDRTHEFFADLQRLGIPTLVFSAGLGNSVVSVLRQANVLHPNVKVVSNFLQFRDGLLDGFQQPMIHTFNKNETVLNETSEYYDLVHTRDHIIVMGDSIGDADMASGVPASSHIMKIGFLFDHVEANMKKYMDTFDIVLVDDQTMDVPRTLLSLIEKQHKLNLEAPKQSSL
The following text describes a protein:
Function:
Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MNNIFAYKEIESPIDDQICKDYKTKYANPSIPIIIDNGSYQCRAGFANDISPKLIFRSLVGKVKSTSSPIVGNSLKEGDISRLTIKSPFDSNLLVHPPSQESIFDYIFHKFGIENEIENPVLITEPTSNPTFCRKYMSELLFECYNIKSVVYGIDSLFSFYGQRDQFKDGGKNSLIIGSSFNTTHIYNVQNYNVSHQQTKRINIGGGASTDYLRKLIHLKYPKHKSYFTQNYTNKIKEEHCYVSQGQYIEELKEFENDQLAKEKSVIIQLPYQEIDFEKLEEERQRKIQNRKDLGAKLRELADKKRLEKKTELEDKLASLESILALKTTNVEEFQQTLKSKSYATEKDLIRDIDDLKDKLFGKKKESEQVEDTEEFPLLFIADSELNADQLKEKKKQRQLKSMKDGRLAQKRKRDEEKEKEKEKEEERDRQEEESFLKDPEHYLKDLHSRKSKILEKREARQKQKQKANIVQRNSRLRTIVNPTNHGNYGEKGEEVEDPEEAEESREMAILDKLLNKFDPTSISSAIVSHDDQFPIGEYHTAEDFQVSLGVERIKCPETLFQPKAIIGVDQMGLVEAIISSILSQLPVDTRKLVTENIFLTGGNVNTKHFKDRIHYEIQQIREPYSPLTILKSKDSQLDAWLGARKWCLDNQDNWSNVSISKQDYQEKGYDYIKSHFASNLSLN
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MESREVKVIGVWHSPYSWRIEVALKLKGIEYEFIEDDLSNKSQLLLQLNPVYKKVPVLIHNGKPIVESLIILEYIDETWPELPALIPKNPHQKACMRFWADFFDNTFPEIGRNILKTQGEEQEKEVIKFKEKLEVVEHGLERDFGGQKPFLNGENPGYLELVVGSCLAWVKAQEEMTGAKLISKEETPFLFSWLSEFCEFGVVKEALQNGPDQGRRLEHLKLKRERLLKLTMV
The following text describes a protein:
Function:
Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine (By similarity).
Sequence:
MNKKSVLVIHGGAGVISKSTISKEREEIFLNSLKNILLAGKIILKQGGTSLDVVQEAVRLLEEDPIYNAGKGSVFTELGTNEMDAAIMDGTNLKAGAVGGVSIIRNPIIAARAVMEHTNHCLLVGKGAEEFAKSKNLEIVEPSFFFTQNRYDQLLRAKDEKKLILDHDGENLLEKEKEKEKNNETSTTTTTISVGVDPIDPKYKMGTVGAVCLDSFGNLAAATSTGGMTNKMHGRVGDTPIIGAGVYANKNVAVSSTGTGEAFMRTVAAFDIAAMMEYGSLSLKDASNKVVMEKLITVGDGGVICVDKYGNVEMPFNTEGMYRGYVIIDNNCENDQNDIINVSIYK
The following text describes a protein:
Function:
Has histone acetyltransferase activity in vitro, with specificity for histone H4.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Cytoplasm. Note=C-terminally tagged constructs localize to the nuclear membrane and perinuclear region. N-terminally tagged constructs show a punctate cytoplasmic distribution.
Sequence:
MAPYHIRKYQDSDHRSVVDLFRRGMEEHIPATFRHMLLLPRTLLLLLGVPLTLFLASGSWLLVLLSILTLFLSLWFLAKYTWEKHVMNCLHTDMADITRTYLSSHSSCFWVAESRGQTVGMVAARPVKDPLLQKKQLQLLHLSVSLQHRREGLGKAMVRTVLQFAQMQGFSEVVLSTSMLQYAALALYQGMGFQKTGETFYTYLSRLRKSPMINLKYSLTSREGDL
The following text describes a protein:
Function:
Involved in membrane organization and might act as a sensor of sphingolipids that regulates plasma membrane function. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MVGIRQYGVFTWVFRTFQLAIDTIVLALASALVNQQTSGGSPGKINFSVAVGSFAILTFFLTAVGRFLPTILGNPWLIAFYDFVNWVFALTGGCCIAVAIRVHACDNQKYLDRNHYTQGSMRRCQELKALCFFLWFMFGLYVASFIVQIFIAKNDTPNYTFRGRGRGKGSGPAVAPRPVMSAV
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MAELAPDTVPLAGVVLAGGESRRMGRDKATLPLPGGTTTLVEHMVGILGQRCAPVFVMAAPGQPLPTLPVPVLRDELPGLGPLPATGRGLRAAAEAGVRLAFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAGERKMSALVDASDALRIVMADSRPLTNVNSAAGLHAPMQPGR
The following text describes a protein:
Function:
Essential component of a SCF-type E3 ligase complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, such complex probably mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to activate the pathway. Can partially complement the absence of GID2/SLY1.
Subcellular Localization:
Nucleus.
Sequence:
MSSEKRVGMVEKSNNKRQRVNQVPVFSINDHHDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELCFRQVSPRPSLSLRSVVSALGGYRCLYFLCIRPVLARLPKLLWTRDQLQLSLSLYCVHYYERLYVGAWLGDAPPSSLIFLRKPVNVV
The following text describes a protein:
Function:
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYIDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFPESETKECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLLQWTNPSTMANAKVKLSIPKFKVEKMIDPKASLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP
The following text describes a protein:
Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. In vitro, it can use both NADH and ADP-ribose as substrates; however the relevance of such substrates in vivo is unclear.
Sequence:
MTGFSVSLFVSNLSNVASYLSPIFENIPSTKVVPAQIEKVVSLVSRTGRDLQRYDHAGYRQVVGCVPYRYKKQEVNGVETQVIQVLLVSAQKGKGMLFPKGGWETDESMEEAALRETIEEAGVTGELEEKLGKWQYKSKRHSIIHDGYMFALLVSQEFERWPEAEMRQRRWVSLDEAREVCQNWWMREALEAFINLKCLADDDESGN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MESLDEIQWKSPEFIQERGGNTNNVLEYFSLSPFYDRTSNNQVLMMQFQYQQIQIPPGVSFHQYFQSRLSEMTGIEFVIAYTKEPDFWIIRKQKRQDPQNTVTLQDYYIIGANVYQAPRIYDVLSSRLLASVLSIKNSTDLLNDMTSYHISDGGHSYINSIHGSSSKPSQSSAVSKPSSTNTGTNATTTPITLTTPSGATVPSTVSNGISTSTEIASGVFDTLLNDVVMNDDHLYIDEIPLYGEGSTLERLGLKGNKDAGLSL
The following text describes a protein:
Function:
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MAKECRDAIGTINLVKGQHLDRRTTNQLEDAIKHLTHVAVFLTNLEKRHPANGISVHLRPLFLEAHDGFSLMCSHPPRSQFTVKLDNIAEKFKSAKASRSTRQVIPELLQIIEPENIAKRIKASKPSRSSSPITVDMVGFIESLLGSVHRALFFISAGPPVSMLDKKLRHLQVFFRLISKRGIEHESMKDLFYHVEDVAYTAAQLCVLGSSCHMDNEFSKLLERISRPFSPGLRLVYLNALIGLNSSRSKTTMNAKYMLDFVSALQDDLRLRCDNRIRWLQRGLSYLCRFLRDIESYPVSHRQLISLQLNMEDLAIGSANAIYSYDEDMDKTSEIDHELFHLQMKFNYVKVEVDLIRLQNIQGTIIVPMKDLIDYVWEELMFFRSYFMDAFDQCKEQTRITVILNYIQSAVSQAWSVCDSLCHDLNQNDLAREINCLHFQLLLKFKFIKVAIRQMCPSISASSTPDHPMIDLLNFLPMNFEAIDSYSSMLKASFPSSPHRPNRDAESPNTSFLCGPNTDVYSFYSSSSRIPKMDEILKRFHEYILVNLLRKDETNLTFTIADEVKKFYDGLLLMVTYLIEPPVPHTECRKQNDLSMRHEAVAIEAESAVCLHYEDNMNNNRCREINQVLQFLTVTFWLIKSEGNLMDLLKHKSTLGNQVLDLIESAHEELILLRSILMDLLRKKLYRLDDLLMHAEVTAKRLAIFSGSCYEYFMNGSSTEKMRPLLSDFLQEIESVKVEFRNVCLQVLDISPFSLTDGEGLVNFLLKNQAKVPNDDAVSSDGSLEDASSTEKMGLPSDFLREIESVEIKEARKLYDQVLDATHCETSKTDGKSFINIMLTQQDKVLDYDAGSVSYLLNQISVVKDKLLHIGSLLVDIVQYRNMHIELTDLAERVQDKNYICFFSVKGYIPAWYYTLYLSDVKQLLKFVEAEVKIICLKVPDSSSYSFPKTNGLGYLNCFLGKLEELLRSKLDLIIDLKHQIESVKEGLLCLRSFIDHFSESYDEHDEACGLIARVSVMAYKAEYVIDSCLAYSHPLWYKVLWISEVLENIKLVNKVVGETCERRNTEVTVHEVAKTTTNVAPSFSAYTQRANEEMEGFQDTIDELKDKLLGGSPELDVISIVGMPGLGKTTLAKKIYNDPEVTSRFDVHAQCVVTQLYSWRELLLTILNDVLEPSDRNEKEDGEIADELRRFLLTKRFLILIDDVWDYKVWDNLCMCFSDVSNRSRIILTTRLNDVAEYVKCESDPHHLRLFRDDESWTLLQKEVFQGESCPPELEDVGFEISKSCRGLPLSVVLVAGVLKQKKKTLDSWKVVEQSLSSQRIGSLEESISIIGFSYKNLPHYLKPCFLYFGGFLQGKDIHVSKMTKLWVAEGFVQANNENGQEDTAQGFLDDLIGRNLVMAMEKRPNAKVKTCRIHDLLHKFCMEKAKQEDFLLQINSGEGVFPERLEEYRLFVHSYQDEIDLWRPSRSNVRSLLFNAIDPDNLLWPRDISFIFESFKLVKVLDLESFNIGGTFPTEIQYLIQMKYFAAQTDANSIPSSIAKLENLETFVVRGLGGEMILPCSLLKMVKLRHIHVNDRVSFGLHENMDVLTGNSQLSNLETFSTPRLFYGKDAEKILRKMPKLRKLSCIFSGTFGYSRKLKGRCVRFPRLDFLSHLESLKLVSNSYPAKLPHKFNFPSQLRELTLSKFRLPWTQISIIAELPNLVILKLLLRAFEGDHWEVKDSEFLELKYLKLDNLKVVQWSISDDAFPKLEHLVLTKCKHLEKIPSRFEDAVCLNRVEVNWCNWNVANSAQDIQTMQHEVIANDSFTVTIQPPDWSKEQPLDS
The following text describes a protein:
Function:
Essential signaling protein which has a major role in many developmental processes; involved in cell fate decisions that require cell-cell interactions. Probable membrane-bound receptor for putative ligands lag-2, apx-1, dsl-1 and osm-11. Upon ligand activation, and releasing from the cell membrane, the lin-12/Notch intracellular domain (NICD) forms a transcriptional activator complex with lag-1 and lag-3 and regulates expression of various genes. Required for ventral cell fates in the postembryonic mesodermal lineage (M lineage) and in uterine precursor cells. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Best known for involvement in cell-fate decisions during development, but also plays roles in other events. Regulates recovery from the dauer larval state. Modulates chemosensory avoidance of octanol and quiescence during molting. Promotes basement membrane mobility during tissue remodeling. Involved in establishing left-right asymmetry during intestinal organogenesis.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Note=Localizes to the apical cell membrane of vulval precursor cells; [lin-12/Notch intracellular domain]: Nucleus. Note=Becomes localized to the nucleus during signal transduction.
Sequence:
MRIPTICFLFLLISLSKSLHIGSCLGLICGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQCDVSKCGADEKCVFDKDYRMETCVCKDCDINGNSLLKPSCPSGYGGDDCKTQGWCYPSVCMNGGQCIGAGNRAKCACPDGFKGERCELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADHPDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNPCSHGVCISFSGGFQCICDDGYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIPDICNHGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCEKECPIGFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGFCVCPPDFTGNQCEVNRKNGKSSLSENLCLSDPCMNNATCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGGVCINEEEKGRKCECSYGFSGARCEEKINLTGFTEKDSLLRSVCEKRKCSERANDGNCDADCNYAACKFDGGDCSGKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDGMDCLPAVVRCPVKIREHCASRFANGICDPECNTNGCGFDGGDCDNETNATIITNIRITVQMDPKEFQVTGGQSLMEISSALRVTVRIQRDEEGPLVFQWNGESEMDRVKMNERQLTEQHVLSTSISRKIKRSATNIGVVVYLEVQENCDTGKCLYKDAQSVVDSISARLAKKGIDSFGIPISEALVAEPRKSGNNTGFLSWNALLLIGAGCLIVMVVLMLGALPGNRTRKRRMINASVWMPPMENEEKNRKNHQSITSSQHSLLEASYDGYIKRQRNELQHYSLYPNPQGYGNGNDFLGDFNHTNLQIPTEPEPESPIKLHTEAAGSYAITEPITRESVNIIDPRHNRTVLHWIASNSSAEKSEDLIVHEAKECIAAGADVNAMDCDENTPLMLAVLARRRRLVAYLMKAGADPTIYNKSERSALHQAAANRDFGMMVYMLNSTKLKGDIEELDRNGMTALMIVAHNEGRDQVASAKLLVEKGAKVDYDGAARKDSEKYKGRTALHYAAQVSNMPIVKYLVGEKGSNKDKQDEDGKTPIMLAAQEGRIEVVMYLIQQGASVEAVDATDHTARQLAQANNHHNIVDIFDRCRPEREYSMDLHIQHTHQPQPSRKVTRAPKKQTSRSKKESASNSRDSTHLTPPPSDGSTSTPSPQHFMNTTHTTPTSLNYLSPEYQTEAGSSEAFQPQCGAFGNGEMWYTRASTSYTQMQNEPMTRYSEPAHYF
The following text describes a protein:
Function:
Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation. Connects chromatin mediated regulation of transcription and pre-mRNA splicing. During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation. Associates and probably phosphorylates SMARCA4 and NCOR1. Phosphorylates SRSF1. Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores. Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13. Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Located throughout the nucleus, excluding the nucleolus but enriched in multiple speckles.
Sequence:
MAATEPPSLREQPEMDDADNSEKSVNEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVLDASDKEGLSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTRGKLEITDNKNSAKKRSKSRSKERTRHRSDKRKSKGAVEMMREKANRSKSKERRKSKSPSKRSKSQDQARKSKSPTLRRRSQEKVGKARSPADEKIKSEEKGKIKDRKKSPIVNERSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKQRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPSRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEAVIEQRRIQRQAIVQKYKYLAEDSNISVPSEPSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI