lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDDPSLPVVPAAPGPAPSATAPRVPFHCSECGKSFRYRSDLRRHFARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQVVHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGTLPSPLQPSPGLPPLSSPCSVCCNVGPCSVCGGGGSGGGEGLEGAGATSWGLAEAAAAAAASLPPFACGACARRFDHGRELAAHWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGSSAPPTQVWASGGAPEVAGEGDTAEVGATPPTWDAGLLLSPTGAGVPKLEALLPEDEGAGNAQAPAAAAEASSEDTLYQCDCGTFFASAPALASHLEAHSGPATYGCGHCGALYAALAALEEHRRASHGKGSGEAAPDGEGEQVAGGPGPGSSSRGKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGKFFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MVENGVDTVKEPCTTGHLEHEHLLFELETSDSSSVGLVLRAIYDGDEHEKFLEKLDARISDHDREIEKMCNFHYQGFIDCIRELLQVRSKAQKLKNEVTRTDQELQETAKRVLQRADELVKYGHIQSNIAWTIGSLGVCLPVLDVYAKLMEQMAGRRYYPALKTIEQLEHTYLPRVAQHRFAQSMAVCIPRLRDRIKEASLSELKDFLENIRKHSGHIGEVALNQGCKQQLEEDEDLSAQDLVDFSPVYRCHHIYSVLGARDTFETYYRQQRRHQARLALQPPTNMHETSDGYRKYFSEIVGFFVVEDHILNTASGLVNQAYLDQVWENALTKITAALRTHSAYCTEAGLMLEVKKLILLFGETLRSYGYHVDPVHNLLLEIQEHYNEILMKHCVQTFRNIFDDDSYHPIEVSAEEEYQAVLATFPFRDEALEQAPFPKKFPFSRFVPGIFGQVKEFIRECLKFSEDLNVSQTEVEDMVRKATNLLLTRTLGGCLSSLIKKPNVGLLQLIQITINTNYLEDASVIVAAHYDWLLVEPEGQASNYMMDLIAFLNNVFQAFTNLPFGCQGFFVIYVLLVCCFLCFMSEDFFFFFLLQCFFATCGSFYDKVAQTACMTACQHLANLLLNILTSEEVKYISIGALQQFNLDVIQCEQFASSEPVKGFKEGVLQMFFVELRQLLDLFMTEDWSTYFHDYGKESSRYLRVNASLALLLLEKVREADKKKNIFSSLKQKERDKKKLQETVLRQLRQLTA
The following text describes a protein:
Function:
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.
Miscellaneous:
MISCELLANEOUS: Present with 4339 molecules/cell in log phase SD medium; MISCELLANEOUS: Moves with an average velocity of 3 um/s along actin cables.
Subcellular Localization:
Bud neck. Bud tip. Note=Concentrates to sites of polarized growth, namely to the bud tip during S and G2 phases of the cell cycle and to the bud neck during cytokinesis.
Domain:
The myosin motor domain binds to actin; The IQ domains provide the interaction surface for the myosin light chain MLC1; The coiled-coiled domain is necessary for dimerization; The tail domain is a globular cargo-binding domain involved in vectorial vesicle transport.
Sequence:
MSFEVGTRCWYPHKELGWIGAEVIKNEFNDGKYHLELQLEDDEIVSVDTKDLNNDKDQSLPLLRNPPILEATEDLTSLSYLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRRGELEPHLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSATVQHQVEMSETEQKILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIERNYHIFYQLMAGLPAQTKEELHLTDASDYFYMNQGGDTKINGIDDAKEYKITVDALTLVGITKETQHQIFKILAALLHIGNIEIKKTRNDASLSADEPNLKLACELLGIDAYNFAKWVTKKQIITRSEKIVSNLNYSQALVAKDSVAKFIYSALFDWLVENINTVLCNPAVNDQISSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCIDLIENKLGILSLLDEESRLPAGSDESWTQKLYQTLDKSPTNKVFSKPRFGQTKFIVSHYALDVAYDVEGFIEKNRDTVSDGHLEVLKASTNETLINILEGLEKAAKKLEEAKKLELEQAGSKKPGPIRTVNRKPTLGSMFKQSLIELMNTINSTNVHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRWTFEEFVLRYYILIPHEQWDLIFKKKETTEEDIISVVKMILDATVKDKSKYQIGNTKIFFKAGMLAYLEKLRSNKMHNSIVMIQKKIRAKYYRKQYLQISQAIKYLQNNIKGFIIRQRVNDEMKVNCATLLQAAYRGHSIRANVFSVLRTITNLQKKIRKELKQRQLKQEHEYNAAVTIQSKVRTFEPRSRFLRTKKDTVVVQSLIRRRAAQRKLKQLKADAKSVNHLKEVSYKLENKVIELTQNLASKVKENKEMTERIKELQVQVEESAKLQETLENMKKEHLIDIDNQKSKDMELQKTIENNLQSTEQTLKDAQLELEDMVKQHDELKEESKKQLEELEQTKKTLVEYQTLNGDLQNEVKSLKEEIARLQTAMSLGTVTTSVLPQTPLKDVMGGGASNFNNMMLENSDLSPNDLNLKSRSTPSSGNNHIDSLSVDRENGVNATQINEELYRLLEDTEILNQEITEGLLKGFEVPDAGVAIQLSKRDVVYPARILIIVLSEMWRFGLTKQSESFLAQVLTTIQKVVTQLKGNDLIPSGVFWLANVRELYSFVVFALNSILTEETFKNGMTDEEYKEYVSLVTELKDDFEALSYNIYNIWLKKLQKQLQKKAINAVVISESLPGFSAGETSGFLNKIFANTEEYTMDDILTFFNSIYWCMKSFHIENEVFHAVVTTLLNYVDAICFNELIMKRNFLSWKRGLQLNYNVTRLEEWCKTHGLTDGTECLQHLIQTAKLLQVRKYTIEDIDILRGICYSLTPAQLQKLISQYQVADYESPIPQEILRYVADIVKKEAALSSSGNDSKGHEHSSSIFITPETGPFTDPFSLIKTRKFDQVEAYIPAWLSLPSTKRIVDLVAQQVVQDGH
The following text describes a protein:
Function:
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Subcellular Localization:
Secreted.
Sequence:
MEVSRYLCSYLISFLLFLFHSETACHPLGKRPCRMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNTKLEEKIDVVPVEPHFVFLGIHGGKLCLSCVKSGDEMKLQLDAVNITDLRKNSEQDKRFTFIRSDSGPTTSFESAACPGWFLCTALEADQPVGLTNTPKAAVKVTKFYFQQDQ
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Domain:
The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.
Sequence:
MLDIAQPKIEVVEATETFGRFKIEPLDPGYGHTLGNALRRVLLTAIPGSAITHVRIAGVYQETDVIPGMTEDVVELILNLKGIHLRGRHEGTVQATIQKQGPAIVTAADLMLPEGLSVVDPTHYICTLEHDQARIEITATIEHGRGYLSADQRGILPLGEFPIDAIFTPVPRVNYVVENTRIGQATDYDRLILEVWTNGTIRAQEALDYAARVLVHYYTTIANFNRLMVEPAAQPETNGLEIPAHVYDTSIETLDLSTRTYNCLKRAEITKIGQVLQMDEKALLSVRNLGQKSMEEIRDKLIERGYIPRVLPQSGASR
The following text describes a protein:
Function:
Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart.
Subcellular Localization:
Nucleus.
Sequence:
MEFTASPKPQLSSRANAFSIAALMSSGGSKEKEAAENTIKPLEQFVEKSSCAQPLGELTSLDAHGEFGGGGSSSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEEDVLGEEVQTTQNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQSLTALGTSTASIATPIPHPIQGSLPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV
The following text describes a protein:
Function:
Probable ligand that binds to the torso receptor. Implicated in a receptor tyrosine kinase signaling pathway that specifies terminal cell fate.
Subcellular Localization:
Secreted. Note=Is a component of the vitelline membrane (VM, the inner layer of the eggshell).
Sequence:
MRSWPGLFWLLTLALLADGGRRESQLRIGKAINIFLRYGYLGISMRVIPLNDNSEPDRWVFKEPTKNIYRNLSGLAESHEDTTPGIFHGDFHMEFCENRRQLFQAYFRDFSIERMDKPWEAFTGGWFPDNAAKKLGINTSFIQGDYSYVLVRVVRFRETGRLNAEIPVHQPLEPDVRSRMDQLQIGNITSAVRFMEDVGTHYVNSYTTGNSLYQVFVYSRKNYSMIKERIKSKGLNGLSKLDLYNYFAPWFAAHLGQIRSASANATVERWARRKLQYEYYVVKYVTLLKLHGNSTLLRSLDSLLGNDAILQLDLKSLKPIFREEPEKESWYHEVLDNNVKLWELNMPQSHPTR
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end.
Sequence:
MDFRILDASAFYAGVPFRSSNDCYTTSLVYDEIKHIKKNHDALGTLLETNRLKIREPDAESTKTATDVAKNTGDYPQLSKQDLSVIALGIELEGEIISDDFAISNVARNLGLKISSIMTQGIKDVGRWVHYCPGCRTNHESGKECPMCATPLKRKLLKE
The following text describes a protein:
Function:
Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MLSSMAAAGSVKAALQVAEVLEAIVSCCVGPEGRQVLCTKPTGEVLLSRNGGRLLEALHLEHPIARMIVDCVSSHLKKTGDGAKTFIIFLCHLLRGLHAITDREKDPLMCENIQTQGRHWKNCSRWKFISQALLTFQTQILDGIMDQYLSRHFLSIFSSAKERTLCRSSLELLLEAYFCGRVGRNNHKFISQLMCDYFFKCMTCKSGIGVFELVDDHFVELNVGVTGLPVSDSRIIAGLVLQKDFSVYRPADGDMRMVIVTETIQPLFSTSGSEFILNSEAQFQTSQFWIMEKTKAIMKHLHSQNVKLLISSVKQPDLVIYYAGVNGISVVECLSSEEVSLIRRIIGLSPFVPPQAFSQCEIPNTALVKFCKPLILRSKRYVHLGLISTCAFIPHSIVLCGPVQGLIEQHEDALHGALKMLRQLFKDLDLNYMTQTNDQNGTSSLFIYKNSGESYQAPDPGNGSIQRPYQDTVVENKDALEKTQTYLKVHSNLVIPDVELETYIPYSTPTLTPTDTFQTVETLTCLSLERNRLTDYYEPLLKNNSTAYSTRGNRIEISYENLQVTNITRKGSMLPVSCKLPNMGTSQSYLSSSMPAGCVLPVGGNFEILLHYYLLNYAKKCHQSEETMVSMIIANALLGIPKVLYKSKTGKYSFPHTYIRAVHALQTNQPLVSSQTGLESVMGKYQLLTSVLQCLTKILTIDMVITVKRHPQKVHNQDSEDEL
The following text describes a protein:
Function:
May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway.
Subcellular Localization:
Nucleus.
Sequence:
MEKEKVNDEKPDPENSLDFSEHFNQLELLETHGHLIPTGTQSLWIGNSDDDEEQDEKTEEWYQLQEKKMEKDPSKLLLWAAEKNRLTTVQRLLSERATHVNTRDEDKYTPLHRAAYNGHLDVVRELIAHGADVHAVTVDGWTPLHSACKWNNARVASFLLQHDADVNAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYIKPGLKNSLEETAFDIARRTGIYHYLFEIVEGCTNCSPQS
The following text describes a protein:
Function:
Involved in copper export.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLQTTLLALQGLSCMNCAQRVKAALESREDVHHAEVNVHYAKVTGEADTHALIETIKQTGYQATEAQTPDVELHLSGLSCGHCTETVRKALEAVSGVISADVTLESANVYGKADIQTLIAAVEQAGYHATQQGIDSPKTEPLTHSAQSQPESLAAAPNTVPATNVALATSTVSDTNTVLPTNTALPTNTTSTTSTADTASATSTAPVINPLPVTESVAQPAASEGESVQLLLTGMSCASCVSKVQNALQRVDGVQVARVNLAERSALVTGTQNNEALIAAVKNAGYGAEIIEDEGERRERQQQMSQASMKRFQWQAALGLLLGIPLMAWGLFGGSMTLTPETQTPWLIIGIITLLVMIFAGGHFYRNAWVSLKNGRATMDTLVALGTGAAWIYSITVNIWPDVFPMEARHLYYEASAMIIGLINLGHAMEQRARQRSSNALERLLDLAPPTAKLVTDDGEKVIPLADVQLGMILRLTTGDRVPVDGEIVQGEVWMDEAMLTGEPIPQQKSVGDIVHAGTQVQDGTVQFRASAIGSQTTLARIIKLVRQAQSSKPEIGKLADRISAVFVPTVVVIAIVAGLIWYFFGPQPQLVYTLVVATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRDADALQQASNLDTLVFDKTGTLTEGHPQVVAIHTFNGVSEQQALGWAAALETGSNHPLARAILQRAEGLTLATASQFRTLRGLGVSGEVDGIPLLLGNNRLLEEQQIDTRELQSLIQQQAESGATPVILTANGKPAALLSIRDPLREDSIGALQRLHQLGYSLVMLTGDNPITANAIAKEAGIDRVIAGVLPDGKADAIKQLQAAGHKVAMIGDGINDAPALAQADVGIAMGGGSDIAIETAAITLMRHSLYGVVDAVELSKATLRNMKQNLLGAFFYNALGIPIAAGILYPFTGTLLSPVVAGAAMALSSITVVSNANRLLRFKPKQ
The following text describes a protein:
Function:
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQISSRSGFGYFSYGIRLALTPGIRRFVVLPLLANIILVGGAMYYLFSHLDTWISEWIGQLPSFLSWLSYVLWPLLALTILATFSYFFSTLANFIASPFNGLLAEKVEQHLSGERIGEEGVWALVKDVPRILSREWRKLLYVLPKALGLFLLLLIPALGQTLGPIAWFLFTAWMLAIQYCDYPFDNHKISFHDMRNTLKQNQSKAYGFGMLVAFFTSIPIVNLFIVPVAVCGATAMWVMEFKIQHSPLRQ
The following text describes a protein:
Function:
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Domain:
The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Sequence:
MDNTSFEKREFISVWVRDPQVHKEDFWHTYISYEICLHTNSMCFRKKTSCVRRRYSEFVWLRHKLQDNALLIELPKLPPWNPFFNLNNEFHITQRMQGLQQFLEAVLQTPLLLSDSRLHLFLQSQLSIAKMDACAQGHTHYTVAQAIQRCGGEARFPVEEQHQEDSKTCCDSDCDSTTSSGLGCSIEPATLVEQDLSHNERFAHEFQATNPEAELCSSLSSSPHGHSVI
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MHLKLVHNVDDKMYLFYCNFCQYKTNSEANLTKHTFTNHTTDQKVALFYCHLCQYKTETERNLKRHISTNHASPETIVTHECSQCAFKTRHQVDLKRHIIRRHTAPETIQWYQCDQCDYRAKFTFALKKHIRTKHDIVTTLNTTNVQKHACQHCPFTTRYPGDLKRHILRRHTAVEAIEWYKCEQCDYKAKLKFSLKQHVHMQHTFANQSEFFPCHMCPYKSVNEANLKKHIVKKHSSQKTFECSHCFFTTKLQCYLKRHQKIQHAASEEVKWFKCDQCDYKGKFQMYLQKHIKLNH
The following text describes a protein:
Function:
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
Subcellular Localization:
Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteolytic cleavage also exists.
Sequence:
MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
The following text describes a protein:
Function:
Plays a role in modulating the host immune response and affecting host cytokine production. Structurally and functionally homolog of host CEACAM1, induces endothelial cell angiogenesis.
Subcellular Localization:
Secreted. Host cell membrane; Single-pass membrane protein.
Sequence:
MASDVGSHPLTVTRFRCRVHYVYNKLLILTLFAPVILESVIYVSGPQGGNVTLVSNFTSNISARWFRWDGNDSHLICFYKRGEGLSTPYVGLSLSCAANQITIFNLTLNDSGRYGAEGFTRSGENETFLWYNLTVKPKPLETTPASNVTTIVTTTSTVTDAKSNVTGNVSLAPQLRAVAGFSHQTPLENNTHLALVGVVVFLVLIVVCIMGWWKLLCSKSEL
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Sequence:
MAIDRQRPVLIITMVRTYNFLAPSLYPNTLVDISFPEPTIGVVNVSPADPVVHNLPVKYGEYSALGGVRKMVNVGNNKVVVADDKFQISTLELSSIGTEAPPPPIITSQESVKARANDVWAGLVPVENGTVSALTSGLLTFHPTSGSSSSSRSVPSPLACLASTHLAPNKFAMGGKEVDVSIWDVERTFASSSDSPMVDAGKRKKNALEPGQLWQAKNMPNNYLKLRPPVYHLALSWLNSPDALVSGTKMGTVRRFDTRQRKPVADWKVAREGGVSCLMPGEENELFFSDRSNYLGALDLRTGKVLYSYSSLTATPHHLLPISSENSSPLLPSTKRIGFASVSSDASIRLHTCTTPPPEDQKGNWGSEGKKGDIVGMVGGIGLGGAIFRGYDERELEVRKEAKEDDVGEDESDDEEEMWEGMNEVEDAGEGSDSDEDDNDSEEEAPKKKSKRSRL
The following text describes a protein:
Function:
May play a role in somitogenesis.
Subcellular Localization:
Nucleus.
Domain:
The ripply homology domain is required for transcriptional repression; The WRPW motif is required for binding to TLE/GROUCHO proteins.
Sequence:
MEATRFTFNTATLCSAQHCNCHKLTTKASGMPVQPPVWRPWIVTERDILRRNAIRERRSKPYARPSSTSNGSTRGPEPGPTSFQHPVKLHWSKPVYDYMYQYGKQLLDAFPVQATICIVDEDPAQSDDSDFESDYEDDSDTDYKPLKRNAPILN
The following text describes a protein:
Function:
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
IVTFLIKCLFSRRLIAMFLLLHFIVLMDVKDCALTEGSTITPLCPKGYFPCGNLSQCLPRAFHCDGVEDCGNGADEENCGDTSGWATIFGTVHGNANNVALTQECFLDQYPQRCVCKGTELECVNAGLKSVPVVSSNVTLLSLKKNNIHSLSDKVFIKYTELKKIFLQRNCITYISRKAFFGLHNLQILYLNHNCITTLRPGVFKDLHQLTWLILDDNPISRISQRLFTGLNSLFFLSMVNNHLQVLPKQMCAQMPQLNWMDLEGNGIKFLTNSTFLSCSSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNMISELPPHIFKDLKCLQKLNLSSNPLLYLHKSQFGSLKQLQSLDLERIEIPNINTRMFQPMKNLSYIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRVFVWVIAFITCFGNLFVIGMRSFIKAENTTHATSIKILCCADCLMGVYLFFIGLCDLKYRGQYQKYALLWMESLQCRLLGFLAMLSTEVSVLLLTYLTLEKFLAVVFPFSNIRPGKWQTLAVLICIWIVGFLIAVTPLWKEDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYTVMFCSIQKTALQTSDERSHMGREVAVANRFFFIVFSEAICWIPVFVIKILSLSRVEIPDTITSWVVIFFLPVNSALNPILYTLTTSFFKDKLKQLLHKHRRKSIFKTKKKSVSTSIMWADDSSALKPGALSKINLEDNIVKPIS
The following text describes a protein:
Function:
Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTGKQGVALSESLNPAEKTSLVINGGSLQPKISATNPPPRCTGFGIQEILGLNKEPATAPRSPLSALPAGAHLIAARSVLGPAGVGVGMGLIGPAGIPSFYSQPAFLETVLADGHDVRLQPHNRSARPLDANQSVSSDSEDLSSSERKLSKSSVNQSKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSTVMAEYGLYGAMVRHSIPLPESILKSAKDGIMESCAPWLLVQDGLPINRRYSKSEYPQLFAGMHKKSMEAANLPATAKCDAPQQPSAQRSEDVEAEEKRSDGKSTISKEEMRENSIAALRAKAQEHSAKVLGTVSPGKLLEGKQEKQAVGEKVSEPPSPTEEQKSP
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MEQDRTNHVEGNRLSPLLIPSPPICQTEPLATKLQNGSPLPERAHPEVNGDTKWQSFKSYYGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTVSEPSLSGLLQIKKLKQDQKANGERRNFGVSQGRNPGESSQPNVSDLSDKKESVSSVAQENAVKDFTSFSTHNCSGPENPELQILNEQEGKSANYHDKNIVLLKNKAVLMPNGATVSASSMEHTHGELLEKTLSQYYPDCVSIAVQKTTSHINAINSQATNELSCEITHPSHTSGQINSAQTSNSELPPKPAAVVTEACDADDADNASKPAAMLNTCSFQKPEQLQQQKSVFEICPSPAENNIQGTTKLASGEEFCSGSSSNLQAPGGSSERYLKQNEMNGAYFKQSSVFTKDSFSATTTPPPPSQLLLSPPPPLPQVPQLPSEGKSTLNGGVLEEHHHYPNQSNTTLLREVKIEGKPEAPPSQSPNPSTHVCSPSPMLSERPQNNCVNRKDIQTAGTMTVPLCSEKTRPMSEHLKHNPPIFGSSGELQDNCQQLMRNKEQEILKARDKEQTRDLVPPTQHYLKPGWIELKAPHFHQAESHLKRNEASLPSVLQYQPNLSNQMTSKQYTGNSNMPGGLPRQAYTQKTTQLEHKSQMYQVEMNQGQSQGTVDQHLQFQKPSHQVHFSKTDHLPKAHVQSLCGTRFHFQQRTDSQTEKLMSPVLKQHLNQQASETEPFSNSHLLQHKPHKQAAQTQPSQNSHLPQNQQQQQKLQIKNKEEILQTFPHPQSNNDQQREGSFFGQTKVEECFHGENQYSKSSEFDTHNVQMGLEEVQNINSRNSPYSQTMKSSACKIQVSCSNNTHLVSENKEQTIHPELFAGNKTQNLHHMQYFPNNVIPKQDLLHRCFQEQEQKSQQASVLQGYKNRNQDMSGQQAAQLAQQRYLIHNHANVFPVPDQGGSHTQTPPQKDIQKHAALRWHLLQKQEQQQTQQPQTESCHSQMHRPIKVEPGCKPHACMHTAPPENKTWKKVTKQENPPASCDNVQQKSIIETMEQHLKQFQAKSLFDHKALTLKSQKQVKVEMSGPVTVLTRQTTAAELDSHTPALEQQTTSSEKTPTKRTAASVLNNFIESPSKLLDTPIKNLLDTPVKTQYDFPSCRCVEQIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCRQRKLEAKKAAAEKLSSLENSSNKNEKEKSAPSRTKQTENASQAKQLAELLRLSGPVMQQSQQPQPLQKQPPQPQQQQRPQQQQPHHPQTESVNSYSASGSTNPYMRRPNPVSPYPSSSHTSDIYGSTSPMNFYSTSSQAAGSYLNSSNPMNPYPGLLNQNTQYPSYQCNGNLSVDNCSPYLGSYSPQTQPMDLYRYPSQDPLSKLSLPPIHTLYQPRFGNSQSFTSKYLGYGNQNMQGDGFSSCTIRPNVHHVGKLPPYPTHEMDGHFMGATSRLPSNLSNPNMDYKNGEHHSPSHIMHNYSAAPGMFNSSLHALHLQNKENDMLSHTANGLSKMLPALNHDRTACVQGGLHKLSDANGQEKQPLAPVQGVASGAEDNDEVWSDSEQSFLDPDIGGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALWEAKMAEKAREKEEECEKYGPDYVPQKSHGKKVKREPAEPHETSEPTYLRFIKSLAERTMSVTTDSTVTTSPYAFTRVTGPYNRYI
The following text describes a protein:
Function:
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Miscellaneous:
MISCELLANEOUS: Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA, resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized by JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from late secretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of the cycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and high levels of progesterone.
Subcellular Localization:
Nucleus. Note=Localizes to chromatin as part of the PRC2 complex.
Sequence:
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL
The following text describes a protein:
Function:
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
Miscellaneous:
MISCELLANEOUS: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In contrast to form I RuBisCO, the form II RuBisCO are composed solely of large subunits (By similarity).
Sequence:
MDQSSRYVNLALKEEDLIAGGEHVLCAYIMKPKAGYGYVATAAHFAAESSTGTNVEVCTTDDFTRGVDALVYEVDEARELTKIAYPVALFHRNITDGKAMIASFLTLTMGNNQGMGDVEYAKMHDFYVPEAYRALFDGPSVNISALWKVLGRPEVDGGLVVGTIIKPKLGLRPKPFAEACHAFWLGGDFIKNDEPQGNQPFAPLRDTIALVADAMRRAQDETGEAKLFSANITADDPFEIIARGEYVLETFGENASHVALLVDGYVAGAAAITTARRRFPDNFLHYHRAGHGAVTSPQSKRGYTAFVHCKMARLQGASGIHTGTMGFGKMEGESSDRAIAYMLTQDEAQGPFYRQSWGGMKACTPIISGGMNALRMPGFFENLGNANVILTAGGGAFGHIDGPVAGARSLRQAWQAWRDGVPVLDYAREHKELARAFESFPGDADQIYPGWRKALGVEDTRSALPA
The following text describes a protein:
Function:
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MGWTSQHCCVPLCANSSKYNSSISFHSFPKDMSVRAEWIVRVRREDFTPSKTSRVCSRHFQKGDFVNNPGKLRKLKKGAIPTLFSWNDFQIPAPRANCRALYLSCPLTWL
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates EF-Tu on 'Thr-383' in vitro; can use ATP or GTP. Also dephosphorylates in the presence of ADP or GDP. Can only phosphorylate before the ternary aminoacyl-tRNA EF-Tu-GTP complex is formed; interaction with cognate antitoxin phd prevents phosphorylation and dephosphorylation of EF-Tu. Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation by inhibiting translation, stabilizing mRNA and polysomes; these effects are overcome by concomitant expression of antitoxin phd. Binds 70S ribosomes and the 30S ribosomal subunits, the binding site is the same as for the antibiotic hygromycin B. Bacteriophage P1 lysogenizes bacteria as a low-copy number plasmid; doc and phd proteins function in unison to stabilize plasmid number by inducing a lethal response to P1 plasmid prophage loss. Overexpression of doc can induce the mRNA interferase activity of host RelE in vivo; Antitoxin phd binds to its own promoter repressing its expression; toxin doc acts as a corepressor or derepressor depending on the ratio, repressing or inducing expression.
Miscellaneous:
MISCELLANEOUS: The concentration of antitoxin phd in P1 lysogens is far greater than that of the toxin it antagonizes. Such an excess may assure the well-being of carriers of the addicting plasmid.
Sequence:
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSALLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE