lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, telomere. Note=Associates with major heterochromatin, centromeres, sub-telomeres, rDNA and the mat locus.
Sequence:
MPKEDDSLCKIVVRREPLDVLLPYYDASETTVQKILHENDSTLSVKFLAGVEALIKKDELDKYKNGKACLRVWLKHKSRKRYHGYMTSTDKDEEEKNDYLLKSNGSKVLRDSTRTKKFKFGKEFHCALNPSFVSDETASDSATSSSSDTNKKVNRKEHNELSLSHLSFNDTSDFGSSDLSSSEIESTENDNKAPYFSLLYSDGFDFIKFLHVCVCVKCHGREHRSSGKNFVYCDHCSNVYHYDCSPLPSLNKETRNYSQQNGFICPLCSKNSKDVLCNTGFVSGVSSGQDLVIPPSLADRESLSILVNYCKSIRFRCFRCRRVEYFFYLDSNPLSIQRTITHFIKKLVCNECSMHPCDIEEIIAWRTLNSLYPSKATLSNNFVSTSDLSFWSREYFVRSKGKSYLHCFWCSASWLAGISLAKKKNFDGLENASYDATKPIIPVSYTIIDKVWDVQYRSGKNARTAKYKTKKHQLKAISEVTFAFVSWRGLTYYMSNWEPPPKETDRNRWKAWLKGYSDLLECLWIEKAPTASINIDLPFTNLEWHSQPSFIKGGTLMPYQLKGLNWLYLRWYTHHPCILADEMGLGKTVQVISFISVLFYRHKCFPVLVIVPHATVANWERELKKWAPFLQINVLVGSEKNRSLVRDYRLINQKDPKHVSTHVLVISASNVEREISLLRKFQWKVLIVDEGQRLKNDQSSLFYYLSSVKSDFKLLLTGTPLQNNVRELFNLLQFLNPMKINAAELEKRYSIIDTEKVTELHQILKPFFLRRVKSEVLDNFPTKVEVIIPLSMTPVQKGLYKSILSKNLSLLRNITGYANTSSSGGQRTTSLNNILMQLRKTLAHPYIYSPDIEDRNLPYELAMRSLEEASCKFLILRLLVPKLITRGHRILLFSQFIQQLDILEDWFEYKNIAYARFDGASSEMERQSAIDSFNAPNSELSCFLLSTRAGGVGINLASADTVIILDPDFNPHQDMQAIARAHRYGQKKKVLVFVLTTRDSVEEKIIQNAQKKLVLDHLIVESLDQNHNSEKDLESILRHGARALFEEAGDEPSIKYNEYSVELLISEAEKQEDTSTDESDIKSNKFGFFRVWDNKHISSNHYEVKENVLVDEEDVWSVILKQREKDAMLEKTDETTSNRRLRAHHKIHYGEDLNIYDNSDDTDYTVNDRSSPGSPFPIETETISSITDTLSDKQKLKYDSSVNIENLNDESDSQKSADVHFDSILAKSLLATTPKEDEFNKTLSTINLEVANKLTSSEYINDSEMQLIDDPVFYPPYEIIEKNHQLVGRSLSKAVLDNFFLLSSLSDNVRCRCCGIKHLPAHCPLSIVPLEICFLCGTPHFSGRDTCPMLRNKEAIYRLKDSLSKSREPFHIKKQAMARLNSFLQKKEEPTVSSSAKTNELSSKVIIKESIINEAKTL
The following text describes a protein:
Function:
Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of tbx1 that plays a key role in pharyngeal development. Plays a role in the formation of the anteroposterior (AP) axis during embryonic development; required to establish the posterolateral border of the pre-placodal ectoderm (PPE) acting downstream of the retinoic acid receptor (RAR) signaling.
Subcellular Localization:
Nucleus.
Domain:
The Ripply homology domain and the WRPW motif are both necessary for its transcriptional corepressor activity on the transcription activator tbx1; The WRPW motif is required for binding to tle/groucho proteins.
Sequence:
MDSSQYMLKATLTQMCLCSRGVRNVHSEHPQQQDSSLTLWRPWLLGAGDRELDGQQRRSGEADGVPTNTGPKGALGFQHPVRLYMPKSKTSEYLQHMGRKVLASFPVQATIHFYNDDSDSEEEDEEEEMEFYNYYQNCAANGVDSSRGSSDNYSVQGGPKRNIGSHAGSA
The following text describes a protein:
Function:
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone.
Sequence:
MDWSIRQLLVVVIFCFCSSVRSEEWSLTNLPPDMKGVGEISWEDVGVDVPMPPVITKQAPTQHIVDPRELIVIDCEATGSPEIRYSWLKNGRELDVDSDPSISWSAAPNSGTITIELDGDNPDKSYEGKYQCRAANHRGTAVTNEIEVIITASPLFAFAEDREITVPVGAQHVLKCLSILGEAIPPPTIYWTKDGSNPIDLTERISIDAENSLIFANVEEGDAGEYSCRAEYSKLGTIRIANTLTLIVDTASPRGARAPSFLKRDINLPPVNRGEDLTLRCITEGLPTPEVRWRRTSGGSLPSARARVVGTSLIIEEVVERDAGSYECTASNSLGKDTYEVMVTVNAAPYWKTEPEGQMLAPGDDATILCEAAGTPTPEVSWKRNGEPLGAKHGLIRDHHFEEKLQDQANRRVSGTTLSLQELVKDNSAVYQCIARNNLGTRITNAYINVVELPPIMLTAANKKYAYVQDQDAQLDCLSFGSPKPEITWHQFSNLSDVNNNTDGSDRYKEELLAGDRYQVLSNGTLVITTVSTEDDGKYKCMAINKFGEEPLQAELSVKRKTTIATPPIALEVRAGNEAQFVCAVDKDPDLELTITWLKNGIPIMPGSRIMQPVLGTLLIKDTINSDSAIYTCLARTTRDEASAQAALSVIDVPEPPMNLQLSNQADSSVTLSWNVGSDNNSPIEGYTIQYEENRMMPGEWQEMKVIDGKDILTADLDLNPWLTYQFRVTARNKVGESEPSDATEGYTTPAAAPSSVPGGIKGEGTEPTNMVISWEPLPGLQQNGPGLKYEVRYRQQPEARKRRQADSDWTTETVNDPNGNEFIVEDTPTYTAYEITVQAKNDFGDGPLSDVVVGYSGEDFPAAAVENTAVRDVQPRSVRLDWDPVDEESVNGDLKGYKVRYWSDDDPDNVMEKTFEGDEPTALIDGLTPFKNYNFTVVPYNGKGDGPPSSPPVKASTPESTPGAPGALRANVVDSKTLDVQWEAPLEPNGAITGYLLTYRTMPGPGVPEGRLGTPVEEVFDDPAKTSVRLEELDEQTWYRIELRAKTKIGPGDVKELETSTSDPAPETTTVMTTTDMATTEGAVPLIPLVPDGEGELPDSSKAPLKPETVEILDTGEDFINVSWVPAKVGPRPSQFYVEYRERDLHADDVVVNGTNSEQMWLQTESVDPDPYSETLQKTIDGLNPGTRYQLRVVASNNFGKGWTDIKETTTDGDSPQAQAATPVGRQGWFIGLMCAIALLILILLIICFIKKNRGGKYKVSEKEDALKGDPETQPIKDDAGFGEYRPRESPDEVMAKPPTGSIPSLTGSEKEPGSETDSMAEYGDADPGMFNEDGSFIGQYGADKKQRPPEEPTSPAAFSTFV
The following text describes a protein:
Function:
Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP and ADP to ATP. Shows a preference for GDP. Can also catalyze the synthesis of polyP from GTP or ATP, but the rate of polyP utilization is 75-fold greater than the rate of polyP synthesis.
Sequence:
MSEEPTVSPPSPEQPAAQPAKPARPAARRAPRKPATRRPRVASPAQKAREEIQAISQKPVALQVASAPHGSSEDSTSASLPANYPYHTRMRRNEYEKAKHDLQIELLKVQSWVKETGQRVVVLFEGRDAAGKGGTIKRFMEHLNPRGARIVALEKPSSQEQGQWYFQRYIQHLPTAGEMVFFDRSWYNRAGVERVMGFCSPLQYLEFMRQAPELERMLTNSGILLFKYWFSVSREEQLRRFISRRDDPLKHWKLSPIDIKSLDKWDDYTAAKQAMFFHTDTADAPWTVIKSDDKKRARLNCIRHFLHSLDYPDKDRRIAHEPDPLLVGPASRVIEEDEKVYAEAAAAPGHANLDIPA
The following text describes a protein:
Function:
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, RQC1 is essential for the recruitment of CDC48 to incompletely synthesized nascent polypeptides that are ubiquitinated by RKR1/LTN1.
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSRALRRLQDDNALLESLLSNSNANKMTSGKSTAGNIQKRENIFSMMNNVRDSDNSTDEGQMSEQDEEAAAAGERDTQSNGQPKRITLASKSSRRKKNKKAKRKQKNHTAEAAKDKGSDDDDDDEEFDKIIQQFKKTDILKYGKTKNDDTNEEGFFTASEPEEASSQPWKSFLSLESDPGFTKFPISCLRHSCKFFQNDFKKLDPHTEFKLLFDDISPESLEDIDSMTSTPVSPQQLKQIQRLKRLIRNWGGKDHRLAPNGPGMHPQHLKFTKIRDDWIPTQRGELSMKLLSSDDLLDWQLWERPLDWKDVIQNDVSQWQKFISFYKFEPLNSDLSKKSMMDFYLSVIVHPDHEALINLISSKFPYHVPGLLQVALIFIRQGDRSNTNGLLQRALFVFDRALKANIIFDSLNCQLPYIYFFNRQFYLAIFRYIQSLAQRGVIGTASEWTKVLWSLSPLEDPLGCRYFLDHYFLLNNDYQYIIELSNSPLMNCYKQWNTLGFSLAVVLSFLRINEMSSARNALLKAFKHHPLQLSELFKEKLLGDHALTKDLSIDGHSAENLELKAYMARFPLLWNRNEEVTFLHDEMSSILQDYHRGNVTIDSNDGQDHNNINNLQSPFFIAGIPINLLRFAILSEESSVMAAIPSFIWSDNEVYEFDVLPPMPTSKESIEVVENIKTFINEKDLAVLQAERMQDEDLLNQIRQISLQQYIHENEESNENEG
The following text describes a protein:
Function:
[Isoform Holin-like protein 26]: Probably functions as a holin together with holin-like protein 26. Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Determines the precise timing of host cell lysis; [Isoform Antiholin]: Counteracts the aggregation of the holin molecules and thus of pore formation.
Subcellular Localization:
Host cell inner membrane; Multi-pass membrane protein. Note=Classified as a class II holin.
Sequence:
MKMDTGTKVRTILFLIAWVNQLLSFDNLEPIPVDETTAQQVYDAVSVLFTIVVTVWTSFKNNYLTLKGRKQREALKKNGLTK
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGTLLTNVASSLAVAATLLAAVDLCCRYAGGLTETSARRGDAPNAAHRRRQTAVRHTGPNDLANRWQTYKGMMSSKFGVSKECMICTEKKRPTKFRLPTTQCSHQPDVCIHCLRNYLRVEVVEKGRVGELLVCPSPDCLANVEDRDLRALYQAGDPLIACHEKRLFERALETDPNFRWCPHNGCGNGQLIDDADESTFWSCVTCNSRVCTRHRVVFHEGMTCAEYDAIAPDSDVQENGSRRKRSWRAFFGLAPTAAWELRNAETEERKAAEKLRRRDAAARAREEAASRAALARLGVKRCPKCAQGLQKNDGCDHFTCGTAMGCKAQFCWLCMADWGPIVRNGNKYHKRNCRWYA
The following text describes a protein:
Function:
Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.
Subcellular Localization:
Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures. Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence:
MSDSVNLDEPSTNSTHFLQCLVTEPRKELQGSRDTHVSYLIITKTNLSIFTRAECKVRRRFSDFVKLQEILSRMNEDCVVPPLPAKHKLEYIKGGRFSDNFINRRAKLLNRYITRCALHPVLHQSPHFIAFLENPNWNNYVRFFIQPKLNNTSKLDEISDSLLNAFSKLKEEPTEFDIQRDHVQQFMFGISNLEGSIQKLLRLEKALESDYEDVSIQFDRLASLDQALDVPIESIQNALQQTGTEYANLTEKLTLLLDTIKDVESYAHSLKELLKRRDQKQQDVEALQEYSAKLSLERDKISSGGSNGFSLSKTLDDLRGIDHNDTRLKRLEHVQSELQAVEQAIQEASAVHDAFNQRVREESKLFDSVRQSEMLSAISDYANVHVEFFTNIRDLWIRVKQ
The following text describes a protein:
Function:
Bifunctional enzyme involved in flavonoid metabolism.
Sequence:
MSLAAKTVCVTGASGYIASWLVKFLLQRGYTVKASVRDPNDPKKTQHLLSLGGAKERLHLFKANLLEEGSFDAVVDGCEGVFHTASPFYYSVTDPQAELLDPAVKGTLNLLGSCAKASSVKRVVLTSSIAAVAYSGQPRTPEVVVDESWWTSPDYCREKQLWYVLSKTLAEDAA
The following text describes a protein:
Function:
Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome. The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation. Essential for efficient pre-mRNA splicing. In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development. Part of its role in promoting embryo tracheal development is also due to specifically splicing bnl transcripts which results in the activation of the BNL-FGF pathway.
Miscellaneous:
MISCELLANEOUS: Named 'fandango' after the Iberian folk dance to highlight the similarity of the blastoderm cellularization phenotype to the charleston/kuk phenotype. The phenotype 'faint sausage (fas)', consisting of a poorly differentiated cuticle and head, was previously associated with the immunoglobulin domain protein CG17716 but is now known to be caused by mutations in the protein 'fandango'.
Subcellular Localization:
Nucleus.
Sequence:
MVTKTIKSLNLEINFEVEDVPYEEEILRNAYSVKHWLRYIDHKAKAPNNGVNMVYERALKELPGSYKIWHNYLRTRRKQVRGKIPTDPMYEEVNSAFERALVFMHKMPRIWMDYGAFMTSQCKITRTRHVFDRALRALPITQHGRIWPLYLQFVRRFEMPETALRVYRRYLKLFPEDTEEYVDYLQEADRLDEAAQQLAHIVDNEHFVSKHGKSNHQLWNELCDLISKNPHKVHSLNVDAIIRGGLRRYTDQLGHLWNSLADYYVRSGLFDRARDIYEEAIQTVTTVRDFTQVFDEYAQFEELSLNRRMEQVAANEAATEEDDIDVELRLSRFEYLMERRLLLLNSVLLRQNPHNVHEWHKRVTLYEDKPAEIISTYTEAVQTVQPKQAVGKLHTLWVEFAKFYEANGQVEDARVVFERGTEVEYVKVEDLAAVWCEWAEMELRQQQFEAALKLMQRATAMPKRKIAYYDDTETVQARLHRSLKVWSMYADLEESFGTFKTCKAVYERIIDLKICTPQIIINYGMFLEEHNYFEEAYRAYEKGISLFKWPNVYDIWNSYLTKFLERYGGTKLERARDLFEQCLDQCPPEHAKYFYLLYAKLEEEHGLARHAMSVYDRATSAVKEDEMFDMYNIFIKKAAEIYGLPRTREIYEKAIESLPEQNMRHMCVKFAELETKLGEVDRARAIYAHCSQVCDPRITADFWQTWKEFEVRHGNEDTMREMLRIKRSVQATYNTQVNMMAAQFLSTNNGAAADAGAGAGPDAMRLLEEKARQAAAESKQKPIEKAASNIMFVRGETQGGAKDKKDTVVNPDEIDIGDSDEDDEEEDDDEENEMTNENQASAAVTKTDEEGLVMKKLRFEQKAIPAKVFGSLKPSNQGDSDGE
The following text describes a protein:
Function:
Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities.
Subcellular Localization:
Secreted.
Sequence:
MKKLVLLFALVLLAFQVQADSIQNTDEETKTEEQQGEEDQAVSVSFGDPQGSGLQDAALGWGRRCPRCPPCPRCSWCPRCPTCPRCNCNPK
The following text describes a protein:
Function:
Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation. Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell. Within the RQC complex, RQC2 specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of RKR1/LTN1 to stalled 60S subunits. Following binding to stalled 60S ribosomal subunits, RQC2 mediates CAT tailing by recruiting alanine- and threonine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails). CAT tails promote the RKR1/LTN1-mediated ubiquitination of incompletely synthesized nascent polypeptides: CAT tailing facilitates RKR1/LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel. Following ubiquitination, incompletely synthesized nascent polypeptides are recognized by CDC48 and degraded by the proteasome. CAT-tailed proteins tend to aggregate and sequester chaperones and can induce proteotoxic stress; their RKR1/LTN1-dependent ubiquitination and degradation is required to prevent proteotoxic stress.
Miscellaneous:
MISCELLANEOUS: Present with 7700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQRISALDLLLLARELKQDLEGYRLSNIYNIADSSKQFLLKFNKPDSKLNVVVDCGLRIYLTEFSRPIPPTPSGFVVKLRKHLKAKRLTALKQVDQDRILVLQFADGHFYLVLEFFSAGNVILLDENRRIMALQRVVLEHENKVGQIYEMFDESLFTTNNESADESIEKNRKAEYTSELVNEWIKAVQAKYESDITVIKQLNIQGKEGAKKKKVKVPSIHKLLLSKVPHLSSDLLSKNLKVFNIDPSESCLNLLEETDSLAELLNSTQLEYNQLLTTTDRKGYILAKRNENYISEKDTADLEFIYDTFHPFKPYINGGDTDSSCIIEVEGPYNRTLDKFFSTIESSKYALRIQNQESQAQKKIDDARAENDRKIQALLDVQELNERKGHLIIENAPLIEEVKLAVQGLIDQQMDWNTIEKLIKSEQKKGNRIAQLLNLPLNLKQNKISVKLDLSSKELNTSSDEDNESEGNTTDSSSDSDSEDMESSKERSTKSMKRKSNEKINVTIDLGLSAYANATEYFNIKKTSAQKQKKVEKNVGKAMKNIEVKIDQQLKKKLKDSHSVLKKIRTPYFFEKYSWFISSEGFLVMMGKSPAETDQIYSKYIEDDDIYMSNSFNSHVWIKNPEKTEVPPNTLMQAGILCMSSSEAWSKKISSSPWWCFAKNVSKFDGSDNSILPEGAFRLKNENDQNHLPPAQLVMGFGFLWKVKTSGNEDNGDDDEEEEEEEEEEEEEEEEEEEEEEEEKEEEEKEEEQQQDEDDSNEVNGLEKGGDSNDSTKNNSFEHDNLEKDIEKHCTISSDTDSDSGNAKAKNDNSSTQRILDEPGVPISLIENINSNVRGKRGKLKKIQKKYADQDETERLLRLEALGTLKGIEKQQQRKKEEIMKREVREDRKNKREKQRRLQALKFTKKEKARVNYDKHKSELKPSLDKGDVVDDIIPVFAPWPALLKYKYKVKIQPGSAKKTKTLTEILHYFKSRPLDGSSTDNEMDWPQEHEMIKGLKEQDLVLLLCVDKLKVTIAGQKSTKNGGNSSKKGKKKR
The following text describes a protein:
Function:
Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDFIKGLWRDLRARPVDTLVRWQEQRFLWLLMAIAMGGLIILAHSFFQIYLYMAPCEQCVYIRYAMFVMVIGGVIAAINPKNIVLKLIGCIAAFYGSIMGIKFSIKLNGIHHAVHNADPDSLFGVQGCSTDPTFPFNLPLAEWAPEWFKPTGDCGYDAPIVPDGVTLSSVQQWFVDLYQQSEGWYLLPPWHFMNMAQACMLAFGLCLILLLVMSGAWALKLARGK
The following text describes a protein:
Function:
Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.
Subcellular Localization:
Cytoplasm.
Sequence:
MLPPKAVFEALSQQASRLFAGESPLPKAELESQFRALMQSAFSKLDLVSREEFDSQMLVLARTRARLEALEAKVAELESKLTPPAD
The following text describes a protein:
Function:
May be involved in 20S pre-rRNA processing.
Sequence:
MAYAGAKEHLVVFHQSIQSIFDGWTGLQLAVRQGYGGPHGLEKARWMVDAVHDWFLENDGIEPYELEDFLADILDHEFDTIVEDDSLNLVATNICTNFHLCTTGHHEAVLEKIKQTPAARIGECVADATEDMEEDDVPDGSVQDANMQAMLGGMRLGQQSHGSSSQNNSEMAGPSSSSSSSLGATGGASSSSSSINSRQEPAEDEDGWTTVRKTKKK
The following text describes a protein:
Function:
Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response, such as biogenic amines and eicosanoids (By similarity). Binds serotonin, histamine, adrenaline, leukotriene C4, leukotriene D4, leukotriene E4, arachidonic acid and U-46619, a stable analog of thromboxane A2. Does not bind noradrenaline, leukotriene B4, ATP or ADP. Inhibits agonist-induced platelet aggregation and hemostasis.
Miscellaneous:
MISCELLANEOUS: The amount of D7L2 in the salivary glands of 5-day-old Culex quinquefasciatus is approximately 36 ng. During the blood meal, mosquito injects approximately 10 ng of D7L2 into the host.
Subcellular Localization:
Secreted.
Domain:
Lipids and biogenic amines bind independently through different binding pockets, with lipids binding to the N-terminal pocket and biogenic amines to the C-terminal pocket.
Sequence:
MNFVGISSLVIVAFFAGGNAAWKPFSPEETLFTYTRCMEDNAKGDLALAKKWMAWKLEADQKSACYAKCVLVGLELFDESSKTFKGDHIVEQYQKYKSYTSQDEAGVKKFQQAVQALGTIDSANCLKVLQKYGPVHAQFTDVQRNVYFGKKEITDKIYNSDYTVKKRDETMFRFCERSNFKDGSEELCTLRKTGITTNNNHLDCLFRGLRYLDRNGNINPDEIKRDLHFINVKDKDAAVDNALNNCKVKEATKATDYNDCLWKDPNLKDIMMPVFDYREVRSESYRYFIENTDPYDVAKVKEKVKKYDKDAGC
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MLLKNCRIIKDNKIIEGDILIDENGRIKKIAKDIKVDDEIIDIKNSLVIPGVIDAHVHFRWGEEKKEDFLSGSLAGINGGVCFAIDMPNNKPPITTKELFYKKLEDCKKDSKINVFLNFGVTENNYLGTVEDAKAYKIFMVKSVGDLFIEDYSKLKDILNQNKLFCIHAEHKDVINENLKKYQLNSWIDHCKIRDEKSEVEAVKEVIKNLKIIDRQSNKKPHVHFCHISTKEALYLIKKVRQELKNIKITVEVTPHHIYLNKDMAEELKGFGKFNPPLREKDDNIALIKGIVNKDVDIIASDHAPHLLEDKLKNVKNCPSGIPGIETIVPLTLNLVNKGLISLFDAIRVLSKNPAKIFNINNKIEEGNLANLTIIDLKKEGKINAELFKSKAKFSPFDGWEVKGFPIYTVINGTLYEAYGCKC
The following text describes a protein:
Function:
Selectively catalyzes the addition of fucose in alpha 1-2 linkage to Gal-beta-(1->4)-Xyl-beta-R, Gal-beta-(1->6)-GlcNAc-R, Gal-beta-(1->3)-Gal-beta-(1->4)-Glc and Gal-beta-(1->3)-Gal-beta-(1->4)-Xyl-R acceptors but not Gal-beta-(1->3)-GlcNAc-beta-(1->3)-Gal-beta-(1->4)-Glc. Unlike in mammals, unable to fucosylate Gal-beta-(1->4)-Glc-beta-R.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MRNVKGLFSYMTKTKSFYISIIVIIFIIFIVNRMGPRNYNYKQIGTEINCVKHKVDEQRYLLFPMITILYKYGLGNQLFEVFSLLGSAQTLNRTAIFNADDDILQSKLDLLQKQVPQVAARIISIPIEIAESTRYLFLPACCHYQFPSLFSCERSKFLVIDGQYFQSFKYFSAIDSLIRKLLKPPIDEEIILKKMIGRKDELRFKNCVHIRRGDYVNDFDHAETSSYFTIRAIDYVHTLHPGLVYLISDDPKWVRKQIAEHLDYHDDVKIMETPINAAIRDLYFSQAHCDSVLITAPSSTFGWWIGYMSKNQSNVYYRDIQETDDMVKYKMVEEDFFPPTWKKLGMSRNGSIISK
The following text describes a protein:
Function:
Associated with the protein storage vacuole formation.
Subcellular Localization:
Protein storage vacuole. Golgi apparatus, Golgi stack. Golgi apparatus, trans-Golgi network. Prevacuolar compartment.
Domain:
The BURP domain located at the C-terminus has not been identified in non-plant proteins.
Sequence:
MASTFRLSISFLTLILFSLWVVEAHTSRKLISIKEKEGQDISHLLKDGEFDDPSLYMYFTLNDLKLGTKLLIYFYKNDLQKLPPLLTRQQADLIPFTKSKLDFLLDHFSITKDSPQGKAIKETLGHCDAKAIEGEHKFCGTSLESLIDLVKKTMGYNVDLKVMTTKVMVPAQNSISYALHNYTFVEAPKELVGIKMLGCHRMPYPYAVYYCHGHKGGSRVFEVNLVTDDGRQRVVGPAVCHMDTSTWDADHVAFKVLKMEPRSAPVCHFFPLDNIVWVTK
The following text describes a protein:
Function:
Probably plays a role in host phagosome maturation arrest, as well as a role in the synthesis of acyltrehalose-containing glycolipids.
Sequence:
MRIVNAADPFSINDLGCGYGALLDYLDARGFKTDYTGIDVSPEMVRAAALRFEGRANADFICAARIDREADYSVASGIFNVRLKSLDTEWCAHIEATLDMLNAASRRGFSFNCLTSYSDASKMRDDLYYADPCALFDLCKRRYSKSVALLHDYGLYEFTILVRKAS
The following text describes a protein:
Function:
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Required for the massive protein sumoylation in the nucleus induced by heat shock and controlled by SIZ1. Involved in the regulation of the heat stress transcription factor HSFA2 in acquired thermotolerance.
Miscellaneous:
MISCELLANEOUS: Stress conditions rapidly and substantially elevates the amount of SUMO1 and SUMO2 conjugates with a concomitant reduction in the amount of free SUMO proteins. The SUMO conjugation system plays an important function in stress protection and/or repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSANQEEDKKPGDGGAHINLKVKGQDGNEVFFRIKRSTQLKKLMNAYCDRQSVDMNSIAFLFDGRRLRAEQTPDELDMEDGDEIDAMLHQTGGSGGGATA
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MDKKEKRPTVLFFDSGVGGFSVYREAKKLLPNWHYLYCFDNAGFPYSERKEESIIHRTLAACQLINQRYPLDAMVIACNTASTVVLPPLRAAFDIPIIGTVPAIKPASEITKTKHIGLLATKGTVKRHYIDELIDKFAQDCIVERLGTTKLVEIAEQKIRGHSVDLISLKDELSSWAGMADLDTLVLGCTHFPLIKDEIQLCLPQVKYFMEPSAAIAKRIKYLLDDKNLQAQNEKYNQMFCTAHFPEESQFKKALHLWGFESLEVIKID
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGNRGSKAKNTGEEEPEAGAVVRAQPSGEPTSTNPFKPNNRKCTDVLRQTAAAHLGHGLDGTHLRRQADKTDTVPAYDFTAYKYMIYPRLSEDLMALSASGMSAKQLARPSTLRKLFGVCVPSCPVLSDTGNDVYVHAYLDYTMHMAPVNEDDQSAGAAMEYEKAGSPWKLITNSSNVLYRCVELTKIEVTQHARCVDDCTDEEQKSYVAGTPLTCGTDETKNPFRDCGDQTCAEMVTTLRPNCTSLETTREERQIGSTTEDPITNMLSRKWYMVARWLGDLQKAAFPILICGGLFAMVLGLFWLVLLRYCAGLFVWLVIVFVVIMQIVVTVFCAYEGNLIDSTSMQSSLTNMGMSSTKAQALTAATTTYITSAGITAAEDQAHYWAIACYVLTAIDALLLLLLIFMCGRIRIAIGIIREASKALQSMPMLTLYPIVPTFFAVGLVAYWLVAAAFIATSGEVSLSEVAGAASNVTGTNIAVPVEMKENNTMHYLMIYHLFGLLWTSQFIQAAAYATIAGAFCEYYWTLDKRQVPARPVLRSMWRTIRYHFGSVAFGSLIIAIVQFLRIALEYVDQKMKAAKQGNAIVKVVMLCLKCFLWCFEKCLKFLNKNAFIIMAMKGRSFCPSMKDSFTLLLANAARVATVSIIARFLMILGKIFITGFCMLFMFVFIRYPPTHLPSFFMGDLASVSSPIFPMLLTGVLSYATASFFLDVYGTGIDTILLCFCEDCNVNKTSEQYYMSDELVAFIEGPAKHNAFTVYQSRSVSNTRDSVAATAPPIFQPHTGPVTKGP
The following text describes a protein:
Function:
FAD binding oxidoreductase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde. EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline. EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine. Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A. Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus.
Sequence:
MSHRILCVAFCVCSLVAVSSIYSPPFNHPIVYSNNAICFQLSTWRIPQLYLAVLIRRFDLSLSTRGVMLAVTVGVGSSQHHSQRSGLSLTFAMTPSMITLLVKTCVISQRTAVGEPHRPGWVWEVGRTEDETCHAHSPRGAPCHQGRIPLYSAAVESVDQIQVAVRFAQRHRLRLVVRNTGHDTAGRSSGSDSFQIHCHRMKQIEYHDNFRALGSDIDRGPAVSVGAGVTLGEMYARGARDGWVVVGGECPTVGAAGGFLQGGGVSSFHSFIDGLAVDNVLEFEVVTAKGDVVVANDHQNPDIFWALRGGGGGTFGIVTRATMRVHLNSPVCVSEVAVSGLRNNSLLWTKGITGLFSILRSFNQQGIPGQFILRPLSKDQVNASLTLYSLNTDDTRRSAENMLSIRNILESTTLPFTLASRCLPKISDALRKGPDMLPVNYGIITGSVLVSEDLFNSEEGPLHLAKQLEHFPMGPMDLLFTSNLGGNVSANTGKKHRDTSMHPGWRQAAHLINFVRSVSTPTAHEKARSLEELHSVQMRQLYDIEPDFRVSYRNLGDPLESDAAQVYWGPNYKRLLEIKRKWDPEDLFFSQLGVGSEGWTEDQMCKRQQRLQQMLQYLMSSIAQRVYR