lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MEPTKVPRTTELEFGGPWGAALLTLLLPGGAFYLLLVSGTPGASVLSVPAFPAWRSLWDPTDLGLVLAWIAAQALLAQAPLGKVTEGTPLRDKARLQYRINGCHALGVTGVVLGAGLAGGLRLSYVYNHFLQLAFAATLVAFALSLLLYIKALVAPPSALAPGGNSGNPVYDFFLGHELNWLLRPQVLLRAETRSPGMGGDQHGNADEGGGGPRQPLAGHGPGQRLPAALRGGRFVARGGGLDHHGHPAGRLWLHAGLWGPGLGALPLQPPGSLLGHSPPQGQPPCGRRHHPPERASHAAHGHGATAAGERVVGPGAAPQLPGGPPHGLGLVTHLRSDPRAALLLPGLLPAAAAAPGGTGRAPLPAPVRPGLGGVLPEGPLPHPALRLLKMRKRLWLIHGISSLLLSSQHGGT
The following text describes a protein:
Function:
Involved in endosomal protein transport.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein.
Sequence:
MGHDIKGFSCAFAVGLLFNILACIVSHSGYPIIVVASYFLAPFPNILCRNRDSFSSEKGTFEDIGLFLTGLFITSGFAIPMILAHSDIISGKALAFSMAGGVTVYATIITFLWFFNRHNDEDNNW
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSVLTPLLLRSLTGSARRLMVPRAQVHSKPAREQLGVLDITIGLTSCFVCCLLPAGWVLSHLESYKKRE
The following text describes a protein:
Function:
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.
Subcellular Localization:
Nucleus.
Sequence:
MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQTPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT
The following text describes a protein:
Function:
Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MHQIYSSDVSSITSKSSIAKAEIITMEEEQQRQSCCTWFHSLKVQIWIAWLGVSAGVMAGTVFAIQYQNWIAVTMCFISSGFATLVLHLHLAYKKTQMAGWSETRLRCLAAVGATVSFLSFIAMVFCLVVAGIEHQTLDKQGLMGANLWIAAVWFFMTSKWSALTWRFARKYRAFCEESQPLLAAAPPEYSVTI
The following text describes a protein:
Function:
Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter that promotes recruitment of factors involved in TC-NER. Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites. Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II. Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II. Not involved in processing oxidative damage.
Subcellular Localization:
Chromosome. Note=Accumulates at UV DNA damage sites.
Sequence:
MDQKLSQLIEELTTSGESQLNAQKMKELKKICKSSEEQLSHAYRLLMTQLTQDHAEIRLSAFQIVDELFTRSHQFRVLLVSDFQEFLELTLGTDNDHPLPPPREAAQRLRQAAMQAVEGWNEKFGEAYKKLALGYHFLKHTKKVDFRDINVRTLAERKREEEKQKHLDKIHRESADRAKREMEEMSDEIGCCLTEVENCFRLLVPLDLGPYREDKFFGEASGIAEDHAPCAWSPDLATPRGSGLSGPQDEEQPCCSKDLVASAHHAGSAVGLKAPAPAATEDPCRDEDRHSEHSDPEDFLRSHGLGSHKYTLDVELPSDGLKVQENEDNLAVLHAARDSLKLIQNKFLPAVCSWVQRFTRAGIYSGHLKQAIDLKMELELALKKYEELNIEPGRGQRSRTEALEDSEEEDQDFVEVPEKEGYEPRIPDHLRAEYGLEPKAPLKTLEKHTAVCSVQERTRRRREEEASDPTSAAAQMLRLQDCLSSPSSSSTRGPLGPEEAQKQAERARAPMVPFGVDLCYWGQEQLTAGKILKSDSQHRFWKPHEVEEEVDSAHVSEMLHSRHITFSGKFEPVQHKCRALRPNGRLCERQDRLKCPFHGKIIPRDDKGQPLNPEDRAREQRQQLQQQRAHPDWQDPEFMKDVEAATGVDLGSSKYSKKGKGKKKKHPNLTDLRERANTARARLEKKVFAKGAVQRVVAAMNQMDQKKHEKFANQFNYALK
The following text describes a protein:
Function:
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MVRSAVLGLALGLLLAVVVQPGTANEVFGCGGFVKNVNSELDLSKVEVGLFTPQGSLKIKTECSPSNGYYFIPVYDKGSYVLKVIPPPGWSFEPEQVEIKFDGQTDVCSQGKDVNFLFKGFGITGRVEFQGAPEAGARNVRVELVAEDGSRIGQTITNGNGVFSFTPIKPGRYVVKVQHQRWHFERPEYKVTVASGNTEIPAGSLVVAGFDVEGSVFSDGQPFAAVGFLLYSSQGQKSTAKCSSETVPSVPNAANKAYETNPLCFATPNKNTGQYLFAGVPRGKYLVRPHFSDSKIKFHIRPEAVELVVGNDGVRVKENFEVTGFSVSGRVLRSPNGASVANARVKLNGREIATTGQDGAYTLENIQPGTYTIQVQADDLQFKDHIVKVSLANPSLPDVLVSGFKVCGQVVSKKAHRVAITKKASTMMVEVTSREGSGEWCTYLENGAYTVQVLTSDAEHASGIQFFPVTQTIEVNYSPVEGIVFSQLRATVTGEVRCLGRRESCGELAVTLQALDGSGNAVGQAVNAAVSDAGSYSFQNVLPGSYEVSVPSSKLCWQSNTVKINIKTAKESVPAFVQTGYIVSILSSHGATMAYRYKDTAAREETGATPSKEEEIVLTAGMNMFCVKRAGTYEMRLSGCHRFEEATATEFSTASTVPISVNAKSHRNVVKLVAEAKEQYRVRVVRDGDSTGELVELELTDGRADGGYVYRKEFFLEHGERVTLVPQSEIMLFNPTQLVVTGGSDCADVSTKLRATKGLLINGRTDPPVKDATITLLFPKNADLASQVALTDERGEFRFGPIDPSLAVELSAEKESYVFSAFDRTTSSFSGHKLCEIIVTVKDDAGNRLAGVLLSLSGAESYRKNMVTGEDGTIKFHSLSPSEYYLRAMMKEYEFRPNSRLITVQEGATVQEELVGQRTQFSIYGSLTSLNGEPFPNVAVEAVSDESCGSVLEEATSEFNGQYRIRGLTPGCQYRVRVRTGAGPTAAVDRSIPRERLVTVGKADTRDVNLIAISPLAFVDVTVRVVASQNEHYKTLKIALYRKGSDSPVHTQRIEPPLNPKSKINPGIMVFFPRIPFDGKSYHIELTSTLSEKSYRYSLSAVSFVANASSFYAELPFEPELRTAEGDLNQSSLSAIVLIALIGFVFFKQELAFELLGMAWAKVGTLAGGAMSNRRPTGKEQKNDGGHIDTRDIDVLASTIDGMKKKKTKKVS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of undecaprenol in vitro, which is probably the physiological substrate. Exhibits no detectable activity against other substrates such as monoacylglycerol, ceramide, or diacylglycerol (DAG). Appears indispensable for the maintenance of spore stability and viability in B.subtilis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localized in both lateral and septal membranes.
Sequence:
MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAVLICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAGAVCVFAVISCIIGLLIFLPKL
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIGWGDVYKVVSAMAPLYFALGLGYASVRWWKFFTRDQCDAVNRLVIYFALPFFAFDFNAHAGTFAASYRVLAADAVAKLVVVLAVAGWVASCRWRQWSCAPKAPAARPARPGGGRGPSYSWCITGYSLGTLNNGLLVGVPLLDAMYGKWARDIVVQLSVVQAVVWLPLLLVVFEARQAWLEVTSAPAPDGAREEGDQAVPGSDDVDRPAAAGDGRKTAATGWAFWARLLRTVGLKVVGNPNVYASLLGVLWSSVANRWHLEMPGIIDGSISIMSRTGLGIGMFNMGLFIGLQDKLVVCGPGLTSLGMAMRFVAAPAATMIGALLLGLRGDLLRVAILQAALPQSIGTFIFAREYDLHANILSTAVIVGTLASLPVLATYYVVLGLM
The following text describes a protein:
Function:
When expressed independently of the eut operon it can restore growth to a double pta-acs deletion mutant.
Subcellular Localization:
Cytoplasm. Note=It is not clear if this enzyme is found in the cytoplasm or the bacterial microcompartment.
Sequence:
MIIERCRELALRAPARVVFPDALDQRVLKAAQYLHQQGLATPILVANPFELRQFALSHGVAMDGLQVIDPHGNLAMREEFAHRWLARAGEKTPPDALEKLTDPLMFAAAMVSAGKADVCIAGNLSSTANVLRAGLRIIGLQPGCKTLSSIFLMLPQYSGPALGFADCSVVPQPTAAQLADIALASAETWRAITGEEPRVAMLSFSSNGSARHPCVANVQQATEIVRERAPKLVVDGELQFDAAFVPEVAAQKAPASPLQGKANVMVFPSLEAGNIGYKIAQRLGGYRAVGPLIQGLAAPMHDLSRGCSVQEIIELALVAAVPRQTEVNRESSLQTLVE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSDKDWMFCPTSGYLLHLDPKRQVAACPVSGYERSLAELSSVKVVLRTDMEDYRRRFALEPLVKSVEDEELLKGRKRATVDEPCPKCNHRQLEYYTMQLRSADEGQTVFYECKNCGHKYSQNT
The following text describes a protein:
Function:
Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPHPVCGRVKINRTPPSKAGDGCPSRRRWLAGGAGPPAAPSGSRAVAGGCDAAGPSALAAEPAFTAGKQQQQKEELTDVTAEECGTEKDGSSPLSSGFQSQLPKQAVSVSSERTHKRRAVKPLCCQECTKIKYKNPKVSTPVKGPSVKINTESETSKSRMKPKPCTALSEAIGKPPRISDFGINKYPILELCDIAKVLEVPVGIAAYRYVLPTELKRKNIKCFKKERRKPIWLKRGDKRYAEGVTFYSQTNCTVPKKTTQELPDVVSGLLQKACVRSCEKRSQGSKAGCGVHEEPSVKRSKVSSGKAEDPAKSLNTRQKKQPEQCTGAAEPGASASVLTNGEVKLLSGAESPYLCLGEVTLGNLSGGLQSCPAENELKSSGYAERWDSEKSEAAGDVLPAGDYSDDPPEEELRDARKSRDPSSCRRAVPYLAWWQLSCARTYVAWPGLKAQPWAAPAPGFSEFSRSLDQTPRCLDASVDSNVAGGAAVQMTGAECEAGLRLSAECPSLQQEDDALKGLLGSCSSLGFNTPPQASQESTVHDSSSLLMTPEGQQGAGTVCSVAPSNPSTSTPDREQTVRDCSHGEKEVLPGSDDSKKQELHQFSIPFQRICVSAPLEECEPSARVGRHPLNGGSEALQQWTMRRPAVDPCTLTSEPLPSADQKIKGPRTCLAFKANHSASVPDVSRSSSEDEDGFEDFATLYSGEIMCEIQDACPVGPHSSVTSNPSSTSDGEPSEHIMDVVRAYEQDAIVLDVIQDDPDLFGSLGEVIEAVERPRCEKKSLGIHKLRPTKAPQTGSDYKISAGNRLSVGFHTGLKSPRKKMQGNSAPTLKGVATNVSSCNGGDPSEPATGLSADADCSTLKEAVAGAEGQCDDLETNASRLLGTVEAGSGQELIPAAPGSEAGSKEREEAPDGEKQQQGPAMPSAGSGATEDGFNRSKYCKFFFSATMSCYRKPCRFLHVPLQGDEKFCMEAVEMFLNTCNPDYLQRAVVVFTRYYQNSYPGVYFKSDVLQVLLSTLLRKGLFGGLFAVIQVTTTFGILPSTSLLLQVYKKVKRFGHQEAVPFLLEVTSKCVEAGLELSEDNLSFMQRQLELLQAPRQHIDVIVSMKSRALKEEEEEGGQFDIDEAIAELERCKEQEDWATLGSVFNSVCGTSGSLANLNRFCASVASALLKDLERTPLVPFCKFVETVCQEGRINELGRTLLGRIGISVMFGYHKTQQWTKGRKLLEALNGMKINFFTLKGLLGHERHVSLCQVVNVAADIYLNTGSVEGAINVLKGGASADAFMF
The following text describes a protein:
Function:
Cell surface proteoglycan that bears heparan sulfate. Required for axonal and myotube guidance, is a necessary component of slit/robo signaling and is required in the slit target cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKPKQKISVEPLLLVAILIGVLVAATHAQDQKSVKPSAAAPSAAASRPHDEIYIDDDSIEGSGGRGGIHEDLEKDPDYSGSGFGPDDEDAEPDQHSHSSHNTRISQSSNSGINTAHTPTQTSSTIPTTSTSTPMPTTTPTATTPASTTTAAATQISSFANSSSTTTTTLAPTIPAEPQQPLFPPFDKDLDTESSGDGIDADAEDDDEDDGDDKDYDYNKELDKEIDIDGPEPGHLPPVVHHNTVETGHIPTTDEIDVDGGDEDDNGDSDIDGPRIGGNDGDITERGPGAGGSNVHELDPNTNVNSQPSDTKGIDHRPNGNEVVIMSEDDRTSSFFSQPGILAAVIGGAVVGLLCAILVVMFIVYRMRKKDEGSYALDEPKRSPANNSYAKNANNREFYA
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MQLVFERLVLDDPQNHVVSKSKYADQQALADAGETRVVFYLYQCFSRLNKVAAKLEVPDPEHQSASLTIVSQASTCLCHCEIYPGKKIPQQVFYLLQEYHAEGGHQDSLESFLKKCADCIKGRFDAEEEQVSLLEVLSHSFNLLKKKFGKVSIANRELFVLIDILKYFTKSVSMAMALLDFSTPAELVDLRSFQESLLGAPLCVSCLPRKEADPFEFFEKPSQALMNEHAITESNLWLPLKGLAVELHNLFYSLLRLSPETRNRTLTWIGHCITACSERGKLWNNQVSELFMAVQSGDGFALNLGAVLLRLARPFSEPYSPKLLKVQHQYCSFEPKSEQEANASCMHIRGLSKETCLVPREEGAASESPCGPFNFSTECFFACQRILSLGFRVVHERLARLSQDLNRVRRVYEEARSQGGDSSEVTRRLQDNMEKGMTRFLSLKAVLLEPDSLEHMLQFHVACATWLCHLATAERLDAFQPLCLPFPEHGNARLAYVPEFVIENICDCIVFVKRFSEKSLALVGPNLEHLMTLILLFMGSPQRMNNPHLRARMAEMLEVLITSADDDHFSGIIPSMNRERLFRNHPFVAELPSTLLHVFVSIEMTGQSVTFEQKFHYRRPMYIVLDHLWNMPDHRNKMKSLAAEAEANIECSSPPLFLRFINLLINDAIFLLDEALSYMSRLRELQQERQQQQPLGGPLWSQGEANMQHVGMLAHFHNVMGTETIRTLAWLTTEIKSLFCHPTMVDRIATMLNYFLLHLVGPQKKNLKVKDFSEYEFKPQELVQNICRIYTNLGCANSETAQAFCVAVSRDGRSYSPELFPQAQSVLLKIGQSILSIGVGELAEKILVCIGGPERPEPLLLPSCERWAEGPLQEDLQHLSDKCVYDSFVLESSGSSFVGFLSSDQTDPFNRSPLTMEMVTSDNDLKNKILEWRAKRMTN
The following text describes a protein:
Function:
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Sequence:
MSNIIKYKKKILNGDLLTKEEVEELLEEDITDLAATANEIRESLCGNKFDLCTIINGKSGRCQENCKYCAQSAHFDTDIIEYNILNSDRIINSAISNYNKGVHRFSVVTSGRALNNNEVDTLCKTYSKLKETCSIRLCASHGLLKYEDLKRLKDSGVTRYHNNLETSRKFFTKICTTHKYDDKIETIKNAKKAGIEICSGGIIGLGETMEDRIDMAFTLRELSVESVPVNILNPIKGTPLENQEILSYEEIIKTLALFRFILPTVQIRLAGGRTIISDKGKKALESGVNGAISGDMLTTLGIETSEDIKMIKNLGFEV
The following text describes a protein:
Function:
Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event.
Subcellular Localization:
Mitochondrion.
Sequence:
MAALRRMLHLPSLMMGTCRPFAGSLADSCLADRCLWDRLHAQPRLGTVPTFDWFFGYDEVQGLLLPLLQEAQAASPLRVLDVGCGTSSLCTGLYTKSPHPVDVLGVDFSPVAVAHMNSLLEGGPGQTPLCPGHPASSLHFMHADAQNLGAVASSGSFQLLLDKGTWDAVARGGLPRAYQLLSECLRVLNPQGTLIQFSDEDPDVRLPCLEQGSYGWTVTVQELGPFRGITYFAYLIQGSH
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSYSKVIYRVKPTRLFGVRLRSTVASTQHKELKTDEAPLEQSCAILETPCDVDLIGGKKAHIGGQRISIDFDNTREAYRSKHTLELLRSLLVFKLCTFDFLVDKNKELIDLSKKILGQRLFEKLMKMTFYGQFVAGEDQNSIKPLIEKNQAFGVGSVLDYSVEEDLTQEEAEKKEMDSCVSEAEKESHVDTHACSPQDPECMDHREKKYKAHRQFGDRRGGVISARTYFYADEAKCDHHMETFINCIKASAGSSVDGFSAIKMTALGRPQFLLQFSEVLVKWRRFFTLLAAHQGKDGMAVLEQKLELQQLQDSLIKLGVGAKSDIENWFTGEELGSSGTIDLLDWNSLINDRTKISNLLVVPNMESGHLEPLLSKFTDEEEKQMKRMLQRMDVLAKHAVENGVRLMVDAEQTYFQPAISRLTLEMQRIFNREKPHIFNTYQCYLREAYDNVSVDVELSRREGWYFGAKLVRGAYMCQERSRASEIGYEDPINPDYEATNNMYHKCLEYILEEINHNRMANVMVASHNEDTVKFTLEKMNEMNLSPTENKVYFGQLLGMCDQISFPLGQAGFPVYKYVPYGPVNEVIPYLSRRAQENRGFMKGSQRERSLLWKEIKRRLFSGQLLYTPVY
The following text describes a protein:
Function:
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
Subcellular Localization:
Cytoplasm. Nucleus. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane. Late endosome membrane. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane. Note=Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).
Domain:
The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.
Sequence:
MQTSGNYQPVPIGFTVPSAPPSYEEATFHHPPYPPLHQGMDAKNMSNPPYIVQPVPMQPPVTVQTVYVQQAMTLYDRPVQMCCRSCNSMITTRLEYSSGALAWLSCGGLCLLGCIGGCCLIPFCIDSLKDVDHYCPNCHALLGSYKRI
The following text describes a protein:
Function:
Component of the tartrate utilization system and may allow entry of tartrate and tartrate dehydrogenase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSDSLSTAPGVTPPVNKNTPLSAQQQSVINKLFRRLIPFLFLLFVFAFLDRINIGFAGLTMGKDLGLSATTFGLATTLFYVTYILFAIPSNIMLGIVGARRWIATIMVLWGIASTATLFAVGPNSLYLLRMIVGITEAGFLPGILVYLTYWFPAHFRARANALFMVAMPVTMALGSLVSGYILALDGFLNMRGWQWLFLLEGFPSVLLGGVVWFYLDDTPQKARWLTKEDKQCLQEMLESDRLQLAKQADYGALPQSAMWREIFTPVVLMYTLAYFCLTNTLSAVNIWTPQILQSFNQSSSNITIGLLAAIPQVCTIAGMIWWSRRSDRVQERKMHTVLPYLFAAAGWVLASATQNSVIQLLGIIMASTGSFTAMAIFWTTPDQSISLRARAVGIAVINATGNIGSAVSPVLIGWLKDQTGNFNSGLYFVAGLLVIGAVIFLMIPMKKAPPKAIF
The following text describes a protein:
Function:
Involved in oocyte maturation.
Subcellular Localization:
Secreted. Cytoplasm.
Sequence:
MALEVLMLLAVLIWTGAENLHVKISCSLDWLMVSVIPVAESRNLYIFADELHLGMGCPANRIHTYVYEFIYLVRDCGIRTRVVSEETLLFQTELYFTPRNIDHDPQEIHLECSTSRKSVWLTPVSTENEIKLDPSPFIADFQTTAEELGLLSSSPNLL
The following text describes a protein:
Function:
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MGTSEKRGESSFSGRPPSPGSRVPFPAPCAGVSSRVYASAGVSVKCVCAGECAEGARAAGGAGGGRQGAGEGAGRECVRACNSTPGLCASPGDSIRGGWRRSGRRRVQPARQRPAAGAGGSPRGSRADASRNRVRAEPGRSPGASLAGGPWAAAGRGGRRRGGPPVRCARRRGAPPTRSGAWEPGSWARRRLGGCCAPAPRAAAPGSPPRPRPGHARRRPTMTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPLDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPAEGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLFGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMIKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMTCSTSLAPVFP
The following text describes a protein:
Function:
Important role in G1 events required for bud emergence and septin organization. Coordinates cell growth and cell division at G2/M, essential for efficient cytokinesis and for regulation of SWE1.
Miscellaneous:
MISCELLANEOUS: Present with 149 molecules/cell in log phase SD medium.
Sequence:
MSPRQLIPTLIPEWAPLSQQSCIREDELDSPPITPTSQTSSFGSSFSQQKPTYSTIIGENIHTILDEIRPYVKKITVSDQDKKTINQYTLGVSAGSGQFGYVRKAYSSTLGKVVAVKIIPKKPWNAQQYSVNQVMRQIQLWKSKGKITTNMSGNEAMRLMNIEKCRWEIFAASRLRNNVHIVRLIECLDSPFSESIWIVTNWCSLGELQWKRDDDEDILPQWKKIVISNCSVSTFAKKILEDMTKGLEYLHSQGCIHRDIKPSNILLDEEEKVAKLSDFGSCIFTPQSLPFSDANFEDCFQRELNKIVGTPAFIAPELCHLGNSKRDFVTDGFKLDIWSLGVTLYCLLYNELPFFGENEFETYHKIIEVSLSSKINGNTLNDLVIKRLLEKDVTLRISIQDLVKVLSRDQPIDSRNHSQISSSSVNPVRNEGPVRRFFGRLLTKKGKKKTSGKGKDKVLVSATSKVTPSIHIDEEPDKECFSTTVLRSSPDSSDYCSSLGEEAIQVTDFLDTFCRSNESLPNLTVNNDKQNSDMKTDRSESSSHSSLKIPTPIKAMIRLKSSPKENGNRTHINCSQDKPSSPLMDRTVGKRTVNNSGARKLAHSSNILNFKAYINSEDSDIRETVEDVKTYLNFADNGQI
The following text describes a protein:
Function:
Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGQIKKKHTAGAARNFITRTQAIRKLQVSLADFRRLCIFKGIYPREPRSKKKANKGSTAPVTFYYAKDIQYLLHEPVLDKFREHKTFAKKLTRALGRGDLHDAKRIDENRPRYHLDHIIKERYPTFMDALRDIDDALSMLFLFAALPASDDVSARLVSEAEAICTQWMAFVARERLVRKVFVSIKGVYYSANIRGVEVMWLVPFRFPQNIPADIDFRVMLTFLEFYTTLLHFVLYKLYNENGLVFPPIINSTKLSGVGGINAYVLESRQNAGVVPQIEGNSEAKVENVSAAVLSKAAKADAGEEEEVEEEEEVEDDGLDSFSAEKGDALAQPTFNSTAGQLFSNFTIFIGREVPLDIIEFLIIAFGGKVISESAMDELIDNEDETRGNVIDEKTLKQKFNLASVTHQITDRPTLREKVPGRTYVQPQWVFDSINEGKLLPVSEYAPGERLPAHLSPWGDAGTYDPTADVSDASDDDEDDEDIEVAPEDYDKDDEEEEAEAEAKQHQRELEAEAKGTKADPAAAPKKAKRKADKMTKAEKQEEEDKKLRMIMMSNKQKKLYKKMQYSNDKKSDREAELKKRRKLNEKKEKR
The following text describes a protein:
Function:
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton.
Sequence:
MESKVIVIHHGSHSLKIGLASESVPKTIPNYIARKKKEKISTPTITTTETPTIVSPVESTIINNKSNENNDDIMKIDVENTVTPSEAVGTTTEDVKSTLPMATTITTDEQVKPTSSTSSTSTTEEVEIKPTESMDIDKPITDSKTNITSNIKIEQPPPPINIQTQTKIHIPKKLLEEVEQSVKETTKLLPPVDYIKVRQKPTLYNENNSTTFEIIKKKKKKTSSLSSLTNVSTTPPPYVPQPLNYNEIDYCIGDDAIAVSRDKDKWFAYQPITMSTFNTGIYHSVQSMFDDITQMWKYAIQRYLNIPSSDLSSYGCVYVVTDNIDRKSLKQITTLLLKELQFTSVLFFQESICSSFGVSMATQSCVIDLGHQKISIACVDEGYLLPNTRLTLGYGGEQLTKLLEYLLTGMDKSDSDTLTRQMVAKQIHKYYFPFKSSIYELVDFSPFYLNVFDNIKIENLDYYYNDFQKQRVGTFKVKDIKHDKHMNIYHFNADEVYQVVGMSLFYPNILSQFGGSSVNYLIKSRSLANTSESNLYVEDQKHYYNHYLSSYDHEDPFDDHSHILSFAQNNTSRDNKDGSNNNNIINNNIINNIINNNNNNNNNSSSSSNNNNNNNNSGSNSNINSYNNNNNNNNNNNNNNNNNNNNSFNNVTIVTSTLNSNSTVPSTLNSNSTVPSISNSNSTVPSTSTSTTSSPTKKLKIESSSNCEDNYIDIPLDIAILKSVSQLERSDINKKKYLSNILLVGGGALAPGIQDVLRVCIFKQLEQQYQAQQLQFQQQLQQQQQQQQQLQQQLQNSTNSATTTPTPSSTTIMPLENYIGFANSSIRSDVDCRHAGWRGGAILGCLESTREIWITRSEWQDGKNSSALNKLPF
The following text describes a protein:
Function:
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers mannobiose over mannotriose and has no activity against polymeric mannan. Is also severely restricted by galactosyl substitutions at the +1 subsite (By similarity).
Miscellaneous:
MISCELLANEOUS: In contrast to clade A beta-mannosidases, which are likely secreted, clade B proteins appear to be intracellular.
Sequence:
MSKLQQFPLSKGWSFRDNEATSEDAWMPVPVVPSVVHQDLQANNKLKDPYIGFNELEARWVNEKSWTYKTVFQKPAAPAGSCIVLAFDGLDTFAKVKLDGNVILENDNMFLARRVDVTKALEAEGDHVLEIDFDCAFLRAKELRKQDPRHNWASFNGDPSRLSVRKAQYHWGWDWGPVLMTAGIWREVRLEVYSARVADLWTEVQLASDHQSAQVTAFVEVESVHSGSHRACFTLSLHGQEITREEIGVTENGTAKATFDVKEPSLWWPHGYGDATLYEVSVSLVKEQEELHRVSKKFGIRTAEVIQRPDKHGKSFFFRVNGVDIFCGGSCWIPADNLLPSITAERYRKWIELMVHGRQVMIRVWGGGIYEDNSFYDACDELGVLVWQDFMFGCGNYPTWPNLLESIRKESVYNVRRLRHHPSIVIWVGNNEDYQVQEQAGLTYNYEDKDPENWLKTDFPARYIYEKLLPEVVQEYSPGTFYHPGSPWGDGKTTSDPTVGDMHQWNVWHGTQEKYQIFDTLGGRFNSEFGMEAFPHMSTIDYFVENEADKYPQSHVLDFHNKADGHERRIATYLVENLRTATDLETHIYLTQVVQAETMMFGYRGWRRQWGDERHCGGALLWQLNDCWPTISWAIVDYFLRPKPAFYAVARVLNPIAVGVRREHHDWSVTHAQPPKTSKFELWVASSRQQEIQGTVELRFLSVNTGLEVRERIVHENVSIVPNGTTNLIVDGLIDHTVHSEPHVLAARIWVDGQLVARDVDWPQPFKYLDLSDRGLEVKKISESEDEQTLLISTKKPVKCLVFEEREGVRISDSAMDIVPGDDQRVTIKGLKPGDAPLKYKFLGQ
The following text describes a protein:
Function:
Functions as a co-chaperone for protein folding in chloroplasts.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAATFVTIPAPLFSLKKNNIPSRSNHRLLGWRKQTLTVNAIATKWEPTKVVPQADRVLVRLEQLPEKSAGGILLPKAAVKFERYLMGEILTVGADVGQVNAGKKVLFSDISAYEVDLGADERHCFVKESDLLAVVE