lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MPSKTLTTTSKNSISAQTEEQRVEETHTCHLKNQHEADFDGWKKSRAQTSLPRNLRFTYLNQKVLGVLATEVIPAGTCLGPLQAKHLHPEDTPADVHPQHIWRVYSAGRLDHLLSCEEESSSNWMCFINSAQSPWQQNLAPFQVGMQIYFSAMKVIMPGEELMVGRSLEYRQPMSSSLRTSGLKQPPPTHTDPQGKVRKRKRGYTVTEILDLDPRTDHHTETPLNKPFSTNAQSKHERKVTRDLQNPKLASSSATYSIFDNIQRHVYTSAFPQSSLPRYTLPIIQYMPHNIPLQLVHMYPSSLSPTSNRNHFSLVSIKKSNFRNEATDSIKTKNKPEDSIKLAHSQPPALSNATHSSLYRADDITAKSLHTGVASLNMGRASADGSSSSTTESHDAIKQTVQGYRSLPYPLQRQNGKIQYTCNVCGKNFSQLSNLKVHLRVHSGEKPYRCNICRRSFSQLAHLQKHIQVHTGEKPHECHVCARRFSSCSNLKKHLRLHSGERPYVCKQCSASFTQHVHLRLHRRIHATPQSHQCPHCPRRYTHICSLQIHLQQFCPSSSTTSPASLLGLANKEIERFDVSEEAERLEVSMEMEAIKRMCHVIWAQTLAGASVLQQGAAHINTIKSGSSCSLIPNVSGKQEASE
The following text describes a protein:
Function:
Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex. During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm.
Domain:
The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C pathway.
Sequence:
MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFARVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCDAATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAALSV
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MLISLKNQKKVKIRGIDMVGMPGPMELMFIFAIAILLFGASKLPELARSMGSSVGEFKKAQRESEQNLKDFEKSLKEPITPKTKVQETATKLGIDIKSKTDDQLLEEIQKVAEKPKEVSEP
The following text describes a protein:
Function:
In vitro, catalyzes the formation of R-linalool from geranyl diphosphate (GPP). Can also accept farnesyl diphosphate (FPP) as substrate to produce trans-nerolidol.
Domain:
The Asp-Asp-Xaa-Xaa-Asp (DDXXD) and Asn-Xaa-Xaa-Xaa-Ser-Xaa-Xaa-Xaa-Asp (NSD) motifs are important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MQEFEFAVPAPSRVSPDLARARARHLDWVHAMDLVRGEEARRRYEFSCVADIGAYGYPHATGADLDLCVDVLGWTFLFDDQFDAGDGRERDALAVCAELTDLLWKGTAATAASPPIVVAFSDCWERMRAGMSDAWRRRTVHEWVDYLAGWPTKLADRAHGAVLDPAAHLRARHRTICCRPLFALAERVGGYEVPRRAWHSSRLDGMRFTTSDAVIGMNELHSFEKDRAQGHANLVLSLVHHGGLTGPEAVTRVCDLVQGSIESFLRLRSGLPELGRALGVEGAVLDRYADALSAFCRGYHDWGRGASRYTTRDHPGDLGLENLVARSSG
The following text describes a protein:
Function:
Involved in transport of proteins into the mitochondrion.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MEEDFFFFFFLIFIYDSHTERERQRHRQREKQAPCTGSPTWDSIPGLQALNRCTTQGSLEEDFELFLLLNMERKAAEPWPENATLYQQLKGEQILLSDNAASLAVQAFLQMCNLPIKVVCRANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLDEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGNKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLYTILTTQLTNDELSEKVKNYSNLLAFCRRIEQHYFEDRGKGSSSIRSS
The following text describes a protein:
Function:
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. Produces a large proportion of the chitin that is not deacetylated to chitosan.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPPTSSQAPFHRYSHLDQRSAPDTQESSPADGNHDPRRQSTSFDHPNLYAQRDVFAVPNHPQSTNLNHQPYLHQGRSGSFEEPIYETPQPGHNVGYEDAEPYGHEQHDGTMWSERPSYSAPYDSDIKAPLDPTPYTPDLEADGMVVKEKKVHATEVMATTNARRWWIRITWMMTWWIPSFLLVHLGRMKRADVRMAWREKLAIFMMICLACAVVLFYIIFFGKLLCPDSDKAWNEKELATHQGDDDYYAAIAGKVYDFTNFYKAQHSDLSSYTTSSALMLEFAGQDLTNYFPMPMTVACPNLVTSTDLTLMYSNFTPIVQYAVHTSGPLQTGTDTKLNDINWYTDTLNPALEDYYKGYYVYDKSSIASGADSDSKYWAIYNNKVYDLSNYIYTISYYSSSSGTDLPNYSFLNSDITDLFQTSAGQDITKDMDEKLSALTAEDAANQMTCLNNAFYLGELDFRKTPRCTVQNYLLLAFSIILIATIASKFLAALQLGSKRQPELLDKFVICQVPCYTEGEESLKRTIDSLAALNYDDKRKLIFIICDGNIVGSGNNRPTPRIVLDLLGVDDKLEAEPLLFKSIGEGSKQLNYGKVYSGLYEFEGHVVPYIVVVKVGKPSEISKPGNRGKRDSQVLLMQYLNRVHFDAPMTPLELEIYHQMRNVIGIDPAFYEYIFQVDADTSVTPDSLNRLIACTADDQQIIGICGETKLANENESLTTMIQVYEYYISHHLTKAFESLFGSVTCLPGCFSVYRIRTAEGGRPVIISSVVIDEYAEPNVDTLHKKNLFSLGEDRYLTTLMMKNFPTFKMKFTPDAIAHTVAPSKWSVLLSQRRRWINSTIHNLVELLFLPEMCGFCFFSMRWVVFLDLLGTIILPATCGYLIYLVIVVSTGKAAIPVISLAMIGATYGLQALIFILKREFMLIGWMLVYILAFPVWSVFLPIYSFWSMDDFSWGNTRKVIGEGNQKTVVIDDDEPFNEGMIPYRTFKEYEWNAWEAASLHSESPAPSEKSQRTTRTGQSYRPHPHSIRSPSFHSSASELPSKADYWRDSSPLGMGNESKRLHQVSSDPSMRGDKSFIRGSKPQVERVQSMAGMSMWGSGSVYDPYKQAMGGPGFLHPMMTGNSLASQATFYPPQTQYPMSMYGSPMMMPMGMPMMGLQYAGNASMAGGAAGPRGTMMTMGMGDQSRISSFSMGGPVAESGAGRLVGLSINEEKEVQDEEVLDKLKTWLSKQDLMSVTKRQTREAIYTLFPNAGLQNRAGWLNEQIDKILSES
The following text describes a protein:
Function:
Putative splicing factor that is required for the correct splicing of a subset of pre-mRNAs. Required for the correct splicing of rtf1, a replication termination factor that mediates site-specific replication termination at replication barrier RTS1.
Subcellular Localization:
Nucleus.
Sequence:
MGNDGGSLPTRNELVKEPGKVPPLDIDFKRSVKSSQFSQCAITDEPLYPPIVSCGLGKLYNKASILQMLLDRSSVPKSPSHIKSLKDVVQLQVELDDSGKVLWLCPITRHVMSDTYQFAYIVPCGHVFEYSALKQFGEKMCFQCNQVYEEKDVIPINPNAEQLKTLSKRLLDLALSEKTHSLNKASKKSNKNGDKKRKHVSKSNSKHAKHELRTNRMLDGENVKSETSVTDMERVKRVKI
The following text describes a protein:
Function:
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MVDGTYVNSSVEAISGEADTAAVAELANQMVMNFLYESSSWLAQSTGPFLWKGFRFLFLRLPSSLLVYLINGTVPFYLVVLGSVFTPIIVYLILRSRVLSAYSRLKGDNEDEVIDKKKQLVNDSEAMLMGGPDGKRRSGFSSYLDEFLSAIKIFGYLDKLVFHELTKSMRTQRLEQGEVMLLDDSVGFAIVVEGGLHIYHKIAHSQGSTRESMPLPEDRSFDSNEDDLTINGERFQLLNKVKAGNPVSSLVSILKLFTDNHTPTVVDSSKSSPKQSAQVPIRQLISPFLDGNVERNKATLNMKQVPTAEYEIPSAERAGSNVSSFTQQLYESMLPKDHAAEDVREPLPEIVAYAASDCAIAVIPASSFKRLMVKYPRSASQIIQVILTKLYRVTFQTAHSYLGLTKEIMHTEVVLNNSTNFELPYYLQEAILRKIKNGSKESSVQESIHRATLRSKNVHAHNSPTPNKISRHIALESRDQYNPGDLLSNVPLSRKGSKTASSSSVSIPRISSLRHQKEAASSPLATLRRLEGNDSQNFAPLSSSSPMSVSEKPSVVGGGAHDNISQISFSSALEETEESSWRMALVESMFGYLGITNESIMPPTEDLLFLNNRASSGSSVCSVSSYSHPQTINQDLFRCLSPELVRTKKKAPRQKYTEEMPINVDFNTAKEEFAEGLETLFIPSGATIVEQNGNNKGLYYIVSGELLVCWKNEEDNIEYVLYTVKPGGIAGYLASLIGFKSFVSLRAKTDLYVGFLPIEVLERLCDKYFMIYLKIAETLTKLLSPKILKLDYALEWIHLEASETLFNQNDPANAIYVVLNGRLRQLHQKSKNEERLSRPTTQRKKRKDDNQPNVQVVGEYSQGCSFGEVEVLTAMNRVSTVVAVRDTELARIPRTLFEVLALEHPSIMIRVSRLVAHKILQRSSDIREPTKIVNSANGYRYDFNLTIPPSAGTSSWGNNSDGGSISYKTITILPITYGLPVEEFANKLVSTFRQVGRSTIGLTQCTTLKHLGRHAFDKLANLKQSGYFAELEELYELVVYIADTPVKSSWTSTCISQGDCILLLADASSDPEIGEFERLLINNRTTARTELLLLHPERYVEPGLTHKWLRKRTWVHQHHHMQFVSSQNPSERVDSKAPPIPGAPPNLIGRLKKRERLNQLTKRTQENFARLLPDSIKLTVENISMKYIQKKQKYYTPVSAHKNDFLRLARILSGQAIGLVLGGGGARGISHLGILKAIEEHGIPIDMIGGTSIGSFVGGLYAKDYDLVPTYGRVKKFAGRIGSIWRMLSDLTWPVTSYTTGHEFNRGIWKAFGDIRIEDFWIQYYCNSTNITESMQEIHTFGYAWRYVRASMSLAGILPPITDNGNMLLDGGYLDNLPVLEMKARGCKTIFAVDVGSVDDRTPMDYGDSLNGFWIVLNRWNPFSKHPNVPSMAEIQMRLGYVASVNALEKAKTTQGVVYFRPPIEDYATLDFAKFEEIYQVGTAYGATFLHELEQNGKLPRIPGNEPANGPGIHLLHRRNSI
The following text describes a protein:
Function:
Outer membrane channel, which is required for the function of several efflux systems (By similarity). Required to export RtxA cytotoxin.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKLLPLFVSAALGTLSSAVWAENLAEIYNQAKENDPQLLSVAAQRDAAFEAVTSSRSALLPQINLTAGYNINRSDQAPRESDLLSAGINFSQELYQRSSWVSLDTAEKKARQADSQYAATQQGLILRVAKAYFEVLRAQDNLEFVRAEKAAVGRQLEQTKQRFEVGLSAITDVHDAQAQFDGVLADEVLAENSLTNSYEALREITGQEYSKLAVLDTKRFAASRTTESSEALIEKAQQQNLSLLAARISQDVARDNISLASSGHLPSLTLDGGYNYGNNSNDNAKNTSGEEYNDFKIGVNLKVPLYTGGNTTSLTKQAEFAYVAASQDLEAAYRSVVKDVRAYNNNINASIGALRAYEQAVISAKSALEATEAGFDVGTRTIVDVLDATRRLYDANKNLSNARYDYILSVLQLRQAIGTLSEQDVMDVNAGLKVAKK
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.
Sequence:
MSKKLIALCACPMGLAHTFMAAQVLEEAAVEAGYEVKIETQGADGIQNRLTAQDIAEATIIIHSVAVTPEDNERFESRDVYEITLQDAIKNAAGIIKEIEEMIASEQQ
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MEYLDSVGYLIITFNYNVTAIGKVWLTLMLLLRMAMVLFAGYPLYQDEQERFICNTLQPGCSNVCYDIFSPVSHMRFWLFQTMIVFLPYAMFAVHILHRVVGYMAPTNDHFRKSNTPTYHGVGLQMEIPDFSLAYIVQLLLRTLLEAGFCTGQYFLFGILVPKRFSCSQAPCTSSVDCYISRPTEKSLMMIFIWGTGVISLILGLVDLIYVIHRRRRSERLKRELLLLENDSLKGGCCSDSPPNSNLHGAPEPMALYADSASNDLEKIEEKIKGDSHSLPSYEGETASFQTESSHHDVGKSNMNTNSNKSCSWQVSLTSADGKPTKSDHHLVIPRQLKPKQENCSSSNLGILSPPEKSPASKSKKSEWV
The following text describes a protein:
Function:
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Deteted in nucleus and at the centrosome during interphase. During mitosis, detected on the mitotic spindle, at spindle poles and at the midbody.
Sequence:
MGRIFLDHIGGTRLFSCANCDAILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS
The following text describes a protein:
Function:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase.
Subcellular Localization:
Nucleus.
Sequence:
MVRGTKRRRSSAEKPIVVVPVTRDDTMPVDEDLVVGESQCAASKPFAKLVGVRRGISSIDLADDHFVCGRGSDDAPTNFNFSQVAKDVGLYRFISKIQFSIDRDTETRRIYLHDHSRNGTLVNQEMIGKGLSRELMNGDLISIGIPALIIFVYESADADHHPEELTKKYHVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKNSVNRMKTRCGTPSYNAPEIVANEGVEYTPKVDIWSLGCVLFITFSGYPPFSEEYTDMTMDEQVLTGRLIFHAQWRRITVETQNMIKWMLTVEPSNRPSAVELMSTQWMKCADCRTAKQDILKSIKPISAAAPAALQTTQAGPVKKAKM
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLLNYAPLEK
The following text describes a protein:
Function:
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Phosphorylates YTA7 during S-phase to promote transcription of histones.
Subcellular Localization:
Nucleus.
Sequence:
MKSRVCSEARVYTRVLAPLGEEYWDYENTTIDWRANNSQYEIETKVGHGKYSEVFQGVQLSSRSKVVVKMLKPVKKKKIKREIKVLMNLASEQRAAAGFDKETYYSNRSAEVRVYNRYDQVYTMPHNGHENIIHLLDVIKDPISRTPALVFEYVDNVDFRILYPTFSDMDIRYYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKQRKLRLIDWGLAELYHPKEEYNARVASRFFKGPELLVDYRMYDYSLDLWSLGTMLASMVFMKEPFFHGRSNTDQLVKIVRVLGSEDFEKYLVKYQITLPREFMDMDQYIRRPWKRFINDANRHLCDNEEIIDLIDNILKYDHHERLTAREAMQHPWFAPIRNGEYKL
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.
Sequence:
MSTYDQIEIEDMTFHPDSQMFTYPCPCGDRFQILLDDMFDGEAIAVCPSCSLMIDVIFEKEDLDEYYEEAGIAPPQPIAAAA
The following text describes a protein:
Function:
Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.
Sequence:
MKAWYLLYCKPRSEVRAQQNLALQNLETYLPMVSEEKSQRGQKRICRVPLFPNYLFINFDPSQTSVKQVHSTRGVSRIVNCQEKMTPIDDRIIHAIRMKELTPSQSVLDTPLELKTGEKIRFKDGPFADLEAIFQEKCPNKRCHVLFNIMGQINILTVPEQSVERV
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDFAELEAIEGLRWPWNAWPPSRSDAAALVVPLSVMCSPLMPLPDLPVLPYEPLLCASCRAALNPYARVDYRSALWTCPFCSHKNPFPRTYAGIGENNLPAELFPTYSTVEYALARNPRPNPGPRGGFGLSSSSVPSSLSASASSSSLSGLDASRVLEPAFVFVVDVCSEQEELRALKNEILHVVAQLPENTMVGLISFGSMVWVHDLGYTDCPKVMVFCGDRELTSEKIQQLMRVSNHSKLGMAQSIQKHGFLLPVSECEFNFTSWVEELNSTHNALPGHRPSRATGAAISTAVALLEVCSVNAGGRVMVFTSGPATIGPGMIAETDLSKSIRTHRDLVNGNAPFTDRARGFYKQLAHRLVDGSFVLDLFACSLDQVGTAEIRYPIESSGGFLVLADSFESEQFRKCLRHIFKREGADHLNMNFDATIEIVTTKEVKICGALGPCMSLRKKNNSVSEKEIGHGGTNTWKMSTLMSKTCIAFIFQVSTDNVEPPPVLFIQFMTRYRHGNGGFRLRVTTAARRWVKPHSPELTAGFDQEAAAAVMARLAVHRAEEYHARDVIRWLDKMLIRFTAKFGDYVPEDPSTFRLSSNFSLFPQFIYYLRRSQFIDVFNSTPDETAFFRLMLNREGVVGSLIMIQPTLFQYSFDGPPIPVLLDVSSISPDVILLFDSYFHIVIHYGSKIAQWRKLGYDKDPNHENLRKLLEAPEIDAEALIADRIPVPKLVKCDQHGSQARFLLARLNPSVTQKTLLTDGSEVIFTDDVSLQVFIEHLQELAVQG
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MQNSDSGKKTFLIGITGMIGGGKSTATKILEEMGCFGINADRLAKRYTEPDSPILIELVELLGSEILDEQGKPDRKKISEIVFNNPEKLSRLNQLIHPLVRKDFQKILETTAKGKMVIWEVPLLFETDAYTLCDATVTVDSDPEESILRTISRDKVKKEDVLARIKNQLPLTEKLKRADYILRNRGNIDSLREECKSLYSTLLGKML
The following text describes a protein:
Function:
Involved in eye morphogenesis. May be essential for the normal differentiation of ommatidial cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGGKHQGSGAGASSGGGSLNSSLCNSVMTNATTASSSLTQQQQQLQAKYIKSKRHQSRYTSLQHSGHDSGSYLHLNSLWSIWYGVMLTLFQGYLAMHGAYRFLGCSLIPWKIEPVAELNLQIVLSGVVFILLPVFFTSAVFKVGNLANDGIKLATGARERRCTLSPHDGLEEESRGGTLRALWTHGGPTAAFVHIVIALCLLLPRLLLEARIIENGLLPKEQIWATELDFVVINRRNLMAMSVVGATPFPRHHQPSNQQQSHHQHGRLNLTANSLEQDEEDYFNDTMFTAIRGVPAGGNNNLFDLRPDRMANGRKAAKTTATTRTTTTANKLDAGKGQYFEVPDLINQDIDEEERQELEEAIRGEEDDGDEGVGVGEEGTVIMPDFDELAPRTAVGTSTTTAKASSDADKLNVENWQQLGTLGKADASSSSSSTTSTTTTTTTSTTTTAATTTSTRGTSTTTTTTTIKPMEITTSRQSAHHHHGKSRKHHKHHNKQRQQQPPRRHHVASHEQAILESFPEEETTTRDSSIHRVRPEVLPELPIPSTPVSASNSKIIAIKAKNQKRRISKRAAGVEIEPEYLLGDANINSSEFVAKSNEEEPEESEDFELEDGDFQAVPALTPAPPAEPNGPKSGQDYVRLDGFAGMLQLFFGIDKPIDVAIFSQPPSAEFVNLLCALLVWSVRYPAVFWNTSKAFACVFSLQMVVAALDIILGYVGISNLYKLQIYAEAMPVHQPGLILNAVVTLALYLLSTALVLASSMVMYLYGHGRLATRMRDRSIITLKTHQTWIYFAHCASLCFVLALAVVKAPLLNDLSATYKNNLHCPTFLAALVGVTHLLLWIVIWLCLTIKRRWHFKLPPLDSTYGGLLGKSSAQPLLMSSGQRTGSNSSSSGCNSTSTTVNGGDSKPDMMSTATSTELGMGMGMGIGGGINGGMGGTGMGLAAQEDIYWPKLTPSSPKLKVTFNEVTSTSDDVLLIGDQEQTDGKRHTSRGASVCFASATGEVDDGEYATLRAATAGAVVGITMGSMKRGLSNTSVGVSLLHLSEYDELPPPPPANLHHQQQQQQQQQQRQAHSFAHGHPHDYANLSGLGGISDDNISEEGKLLACVRDDSITYASTSDLEPPQPSAQAPPPPPPLPIKGAPVPQPPAVMPHSAGIYGRAPQAMPEMMQLSPEHHHNPLQHSLQHPQHHPLQQQQQKQQTPQHPLQQQGNPHQHLVSPLAPVTVAVHTNEAHIASSSTPRCLRRADSGVPNEALTPRSDTTSTTESTNTTSPPERAPSESSSGVHSGEERELEVIIRPRANSKPPPRPPQPPIQEEPYGRCTNMRMSSFNADPAATSSAVINSATLPPQRSVPEQKFDYTAHCSTMPLPVGCHSQQLAGSGNGYASTSAMTSSMGGGGMPPLPPSQVSSFMTPNSMHYANASVALGNVSGQQQPHTTLPNGVRYSNPHFLRRLPHVTKAAESPYGHLGYGAGHHAFAKLPHETHPTIPEDRDSANYSMASDQDCGLYVTAQLH
The following text describes a protein:
Function:
Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP. Has no inosine-5'-monophosphate dehydrogenase (IMPDH) activity.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGTTIPVVVANMTAVAGRRMAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTPVTLAPDDSVSDAMALIHKRAHGVAVVILEGRPIGLVRESSCLGVDRFTRVRDIAVTDYVTAPAGTEPRKIFDLLEHAPVDVAVLTDADGTLAGVLSRTGAIRAGIYTPATDSAGRLRIGAAVGINGDVGAKARALAEAGVDVLVIDTAHGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEGTRDLLKAGANVVKVGVGPGAMCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIRHPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTGADNPFDRARKALFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVGASNLAELHERAVVGVQSGAGFAEGHPLPAGW
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MPLITLVSSYGKSYQVETSVFKQSELISSLIEDLNLDIIPDAAAFPIPIRDVTGEVLEKVIEWCTHHKDDPVEMEKEEDSDCVLYPLSPWDEAFFEALRASTTIATMDTIEAASSLEIICFIEHAQKFIANRMMKTPGVDEADDEVAEDPTMLRKCIDW
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Sequence:
MTIAPADPASATPVTATGEPDGPGAALLRTLTGLTADLPGADPGRVAAAALRGRSARADEAELRELATEAAAGLISEDPVYSRLAARLLTIGIRAEAASQGVVTFTDSVATGHREGLIADRTAAFVRLHADRLDALIDQDADDRFGYFGLRTLYSRYLLRHPITRKAVETPQHFLLRVAAGLAEDDTVRAADEVAALYGLMSRLDYLPSSPTLFNSGTRHAQMSSCYLLDSPKDELDSLYDRLHQVARLSKHAGGIGIAYSRVRARGSLIRGTNGHSNGIVPFLKTLDASVAAVNQGGRRKGAAAVYLETWHADVEEFLELRDNTGEDARRTHNLNLAHWIPDEFMRRVDADGTWSLFSPADVPELTDLWGEEFDAAYRRAEEAGLARRTLPARELYGRMMRTLAQTGNGWMTFKDTANRTANQTATPGHVVHSSNLCTEILEVTDDGETAVCNLGSVNLGAFVDPAHGDMDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNARWRPVGLGAMGLQDVFFQLRLPFDSPEAKALSTRIAERIMLAAYETSADLAERNGPLPAWEKTRTARGVLHPDHYGVEPAWPERWAALRARMATTGLRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLSGEFLQVNSYLVDDLKRLGVWDARTREALREANGSVQGFTWIPEDVRALYRTAWEIPQRGLIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKQGLKTTYYLRSRPATRIARAAARATTVPVQAAPDPEAVACSLENPESCEACQ
The following text describes a protein:
Function:
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MAASNKRKRVSHQFANSNNSEGASTSRANNTLHSVGDDKKDHFVEGSIVRISMENFLTYDRCDVYPGPNLNMIVGANGTGKSSIVCAICLGLAGKTGFLGRGDKVGLYVKRGCSKGSIEIELYKCEGNLKINREIHVENNQSTWMINGKHASQKTVEEAVKALQIQVGNLCQFLPQEKVGEFAKMSKVELLEATEKSVGPPEMYRFHCELKNFRSKERELENICKEKAGLLEKMGHQNERYKRDVERYYEKQRHLDVINMLERKKPWVEYETVRRQILAVKSERDKVKSELKKLQDEQAPMLNKIKSVESQLKPLDNKMKEKNIQMKEAWQKCKIKQDQLDRKDKEIEDIQQALSLKQTEEADRQKRINNTRRMIDDWQAELNSIGSQDDVQPKIDSINGQLRHIQEEKAKIDSERADVKREWENQKYEREKLKIELRKHEDLMIRKEEKLKERYRDTYNAMMWLRENRNLFRGNVYEPIMLVVNVRDAQHAKYIENQVSINDLRAFVFQKQEDMEAFMSEVRDKQKLRVNAVIAPPQSCANKPPPRPIEALRRYGFFSYLRELFDAPEEVMSYLCNQYKVNEIPVGNEQTKAMIETVIKESQLRQIFTAEEKYTVKKSVYSNKTITSNTALRPSQFLTSAADADTRRQLEGQLQTAQQKLQELELQMRAFAEQQTQLDRRDNDLRNQKKELSELKGKKRQLEQKISTKLDSLKQMEQNGINLKEEEGKTKEKIKAVNTEKVTIVSDLIESMKKRVKLNMDRVYLALDSVQLTAKKTKLETDCREASARLRVLEDKYLELERKKHTLVCDCKGLMKKAQEICNLDPGQSDVPQDLHDVFKQFPDTVDEIDALLHEERSRAECFTGVNSSVLDEYAERTQEYDNLKVELDKKTKALQEYRESISQVKERWLNPLKLLVEQVNEKFSDFFRSMQCAGEVDLHSDNEEEYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMSLQELNRCPFRVVDEINQGMDPINERRVFDIVVRTACKETTSQYFFITPKLLQNLTYADEMTVLCVHNGPYMLPPAKWNLKAFERRRQRVQRLLA