lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Multifunctional enzyme involved in mRNA capping. Catalyzes the formation of the 5' cap structure on the viral plus-strand transcripts. Specifically binds to GTP and displays guanylyltransferase and methyltransferase activities. Has affinity for ssRNA but not for dsRNA. Capping activity is non-specific and caps RNAs that initiate with either a G or an A residue. Together with VP1 polymerase, forms a VP1-VP3 complex positioned near the channels situated at each of the five-fold vertices of the core. Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell. VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are capped by VP3 and extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins. DLPs probably have an RNA triphosphatase activity as well, whereas open cores do not; Counteracts the host innate immune response thanks to its phosphodiesterase that degrades the 5'-triphosphorylated, 2'-5' linked adenylate oligomers produced by the host cell IFN-inducible 2',5'-oligoadenylate synthetase (OAS). The host RNaseL is therefore not activated.
Subcellular Localization:
Virion. Note=Attached inside the inner capsid as a minor component. There are about 11 to 12 copies per virion.
Domain:
Contains a bipartite N7-methyltransferase domain, a 2'-O-methyltransferase domain and a GTase/RTPase domain. The C-terminus contains a phosphodiesterase domain that degrades the 5'-triphosphorylated, 2'-5' linked adenylate oligomers produced by the host cell in response to IFN stimulation.
Sequence:
MKVLALRHSVAQVYADTQTYLHDDSKDEYENAFLISNLTTHNILYLNYSLKTLKILNKSGIAAVEVQSPDELFALIRCNFTYDYENNIIYLHDYSYYTNNEIRTDQHWITKTDIIDYLLPGWKLTYVGYNGKNTRGHYNFSFSCQNAATDDDIIIEYIYSNELDFQNFLLRKIKERMTTSLPIARLSNRVFRDKLFPSIVNIYKKVINVGPRNESMFTFLNFPTIKQFSNGAYIVKHTIKLKQEKWLGKRVSQFDIGQYKNMLNVVTTIYYYYNLYHSKPIIYMLGSAPSYWIHDIKQYSDFTFETWDPLDTPYSTIHHKELFFDKDVNKLKDNSVLYIDIRTDRKNMDWKEWRKVVEQQTVNNLNIAYKYLSTGKAKVCCVKLTAMDLELPITAKLLHHPTTEVRSEFYAILDAWDIITIKRFIPKGVFYAFINNITTENVFIQPPFKLKASPTDYIVALYALSNDFNSRQDVINLINKQKQSLITVRMNNTFKDEPKVNFKNIYDWTFLPTDFELKDSIITSYDGCLGMFGLSISLSSKPTGNNHLFIINGTDKYYKLDQYANHMGISRRSHQIRFSESATSYSGYIFRDLSNNNFNLIGTNVENSVSGHVYNALIYYRYNYAFDLKRWIYLHSIGKVTVEGGRYYEHAPIELIYACRSAKEFAILQDDLTVLRYANEIEGYINKVYSITYADDPNYFIGIKFNSIPYEYDVKVPHLTLGVLFISDNMIHDVVTVLKKMKTELFKTEISTSYTYMLSDNIYVANASGVLSTYFKLYNMFYRNHITFGQSRMFIPHITLSFSNKQTVRIESTRLKINSIYLRKIKGETVFDMSE
The following text describes a protein:
Function:
Catalyzes the conversion of lactate to pyruvate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGPKIAIVGSGAVGTSFLYAAMTRALGSEYMIIDINEKAKVGNVFDLQDASSSCPNFGKVVAGEYSQLKDYDFIFISAGRPQKQGGETRLQLLEGNVEIMKSIAKEIKKSGFNGVTLIASNPVDIMSYTYLKVTGFEPNKVIGSGTLLDSARLRYAIATKYQMSSKDVQAYVIGEHGDSSVSIISSAKIAGLSLKHFSKASDIEKEFGEIDQFIRRRAYEIIERKGATFYGIGEASADVAEQILKDTKEVRVVAPLLTGQYGAKDMMFGTPCVLSRKGIEKILEIELSNTEKVALENSIKVLKDNIKLAKL
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Located at the septum.
Domain:
Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).
Sequence:
MFWIVLIVILLLALAGLFFVRAQSEREWMREVSAWQEKKGEKQAELPEIKDGMPDFPELALMLFHAVKTAVYWLFVGVVRFCRNYLAHESEPDRPVPPASANRADVPTASDGYSDSGNGTEEAETEEAEAAEEEAADTEDIATAVIDNRRIPFDRSIAEGLMPSESEISPVRPVFKEITLEEATRALNSAALRETKKRYIDAFEKNETAVPKVRVSDTPMEGLQIIGLDDPVLQRTYSHMFDADKEAFSESADYGFEPYFEKQHPSAFSAVKAENARNAPFHRHAGQGKGQAEAKSPDVSQGQSVSDGTAVRDARRRVSVNLKEPNKATVSAEARISRLIPESQTVVGKRDVEMPSETENVFTETVSSVGYGGPVYDETADIHIEEPAAPDAWVVEPPEVPKVPMTAIDIQPPPPVSEIYNRTYEPPSGFEQVQRSRIAETDHLADDVLNGGWQEETAAIADDGSEGAAERSSGQYLSETEAFGHDSQAVCPFENVPSERPSCRVSDTEADEGAFPSEETGAVSEHLPTTDLLLPPLFNPEATQTEEELLENSITIEEKLAEFKVKVKVVDSYSGPVITRYEIEPDVGVRGNSVLNLEKDLARSLGVASIRVVETIPGKTCMGLELPNPKRQMIRLSEIFNSPEFAESKSKLTLALGQDITGQPVVTDLGKAPHLLVAGTTGSGKSVGVNAMILSMLFKAAPEDVRMIMIDPKMLELSIYEGIPHLLAPVVTDMKLAANALNWCVNEMEKRYRLMSFMGVRNLAGFNQKIAEAAARGEKIGNPFSLTPDDPEPLEKLPFIVVVVDEFADLMMTAGKKIEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRIAFQVSSKIDSRTILDQMGAENLLGQGDMLFLLPGTAYPQRVHGAFASDEEVHRVVEYLKQFGEPDYVDDILSGGGSEELPGIGRSGDDETDPMYDEAVSVVLKTRKASISGVQRALRIGYNRAARLIDQMEAEGIVSAPEHNGNRTILVPLDNA
The following text describes a protein:
Function:
May modulate chromatin structure by regulation of nucleosome assembly/disassembly. Could function together with B-type cyclins in the regulation of microtubule dynamics.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSISIKDRSDSDLLPAAAAALSAEDRALLVNALKNKLQNLAMEDADILTTLSPQVRKRVDALRELQGQHDELQAKFLEESAALETKYQKLYEPLYTKRYEIVNGIVEVEGVNVAPLEQGDNQGTGDGTEKGVPNFWLNAMLNNEILAEEISEYDEEALEFLKDIKWCRVNDAKGFKLEFFFDTNPFFKNSVLTKTYLMVDDELPVLDKAIGTDIEWYPGKCLTQKSFKKMQKNGLENVEPVIQVEDYESFFEFFKPPQVPEVDVGFDILDNSLEQLQYQMEHDYEIGSIIRVKVIPHAVALFTGELGEDEDYEVTEYDDEEEKYEKKSNGAQTEEGQQGVHVQQIAEQDMSTLDIYQSHLYPFTADAVVASYAEYRAGLEIKQKDNLQKFSGSPSLKLKSLSPQVRKRVEALKNLQGQPAALKALLLEEKAVLKAGYEKLHESLHTKSERDTLQALFLKEKTVLEAKYEKLHESLHMKRYEIVNGVVEVKGDNMETGDEKGVPNFWLTALKSYAKREEEDIKWCRVDHPKGIKLDFFFDTNPFFKNSVLTKTCHKRVNMAMAKDVTWTDIEWFPGECLTKKIVECNPNKRLITAKPMIRTVDCQSFFKQPPVTELPYMQADYEDYEIGSVDDFFFAWMHAVLWFTGEAEEDDSIYMQFDMEAYEYACRFMVDGIGSYEDTDMYMECDIPRHVKKLDNIEDDDDNEDDDEEEDDDDDDDDEYA
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Sequence:
MGLETLSKGTSPAPMSVVCFGHPLLDMMATVENEFLREHNVDPGSVTLAAPEQLVLFSKLLDEFKGQVDYVPGGAAMNTARVLAWMLPDVHIAYVGALGKDRFAEILKSALTKAGVEQLFEECEDKPTGTCAGLVVQKDRTLLANLGAAVTLSLTHIQTDAVQSAIEKASLYYAEGFFLNTASSPNNLLYVAEHAQRHGKLFCFNLNAPYISIAFQSRLHVLLPHVDILFGSDEDLLTYASVRWPHDFDLKTLGTVMHANSRRHEALVRCLARISMLPRATPARPRLVVGTCGPHDTYVACGDHVRSYPVPPMAQEEMVDVNGAGDAFVAGFLAQYMVSRDESTSVVVGHASAQNCIRHNGAVVSGVPPALTRRISGTTEPVMTANSA
The following text describes a protein:
Function:
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Has activity towards the flp-9 neuropeptide KPSFVRF-amide.
Subcellular Localization:
Cytoplasm.
Sequence:
MTALEKLAKLRSLFHSERVLALTSSKPMVAYLLPSTDAHHSEYLADYDFRVKFLSGFSGSNAYVVVTDREALLWTDGRYFTQAGNQLDSNSWKLMKQGQPDSITVVDWLVRELERGSVIGFDPTLSTFDAGSKTFKRLKAAGLQPVSIPGNLVDEFWTDRPRLAGEPVVVLDVEDTGLTTSKKVENLREKLKQKKCDAAVFTLLDDVMWLLNIRGSDIPYNPLAYSYLFVAMREIHVFIDNEKLDEKSRAHFHKSNVSIHPYGEVYSWISNWLKAKEASKEPHMVYLTPETNYAIGSIIGEENSMVDTSLVQTAKATKNDHEMQGMRNSHLRDSAALVEFLCWLEKELLSGKRYTEIELADKIDHLRSLQDKYVTLSFDTISAVGDHAALPHYKPLGESGNRKAAANQVFLLDSGAHYGDGTTDVTRTVWYTNPPKEFILHNTLVLKGHINLARAKFPDGIYGSRLDTLTRDALWKLGLDFEHGTGHGVGHYLNVHEGPIGIGHRSVPTGGELHASQVLTIEPGFYAKEKYGIRIENCYETVEAVVMSKAQNFLTFKSLTLVPIQTSIVDKSLLIEEEINWLNQYHARVLKEVGEHLQKRGKTDELKWLAEACKPI
The following text describes a protein:
Function:
Transcription activator involved in the regulation of genes expressed in response to environmental changes. When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide. When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) (By similarity). Preferentially binds 5'-TTACTAA-3'.
Miscellaneous:
MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities; MISCELLANEOUS: Present with 1700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTPSNMDDNTSGFMKFINPQCQEEDCCIRNSLFQEDSKCIKQQPDLLSEQTAPFPILEDQCPALNLDRSNNDLLLQNNISFPKGSDLQAIQLTPISGDYSTYVMADNNNNDNDSYSNTNYFSKNNGISPSSRSPSVAHNENVPDDSKAKKKAQNRAAQKAFRERKEARMKELQDKLLESERNRQSLLKEIEELRKANTEINAENRLLLRSGNENFSKDIEDDTNYKYSFPTKDEFFTSMVLESKLNHKGKYSLKDNEIMKRNTQYTDEAGRHVLTVPATWEYLYKLSEERDFDVTYVMSKLQGQECCHTHGPAYPRSLIDFLVEEATLNE
The following text describes a protein:
Function:
Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGLYGQACPSVTSLRMTSELESSLTSMDWLPQLTMRAAIQKSDATQNAHGTGISKKNALLDPNTTLDQEEVQQHKDGKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAIDTNPKEDVLPTRPKKRARSVERASTPYSIDSDSLGMECIISGSASPTLAINTVTNKVTLYNTDQDGSDSPRSSLNNSLSDQSLASVNLNSVGSVHSYTPVTSHPESVSQSLTPQQQPQYNLPERDKQLLFSEYNFEDLSASFRSLYKSVFEQSLSQQGLMNIPSESSQQSHTSCTYQHSPSSTVSTHPHSNQSSLSNSHGSGLNTTGSNSVAQVSLSHPQMHTQPSPHPPHRPHGLPQHPQRSPHPAPHPQQHSQLQSPHPQHPSPHQHIQHHPNHQHQTLTHQAPPPPQQVSCNSGVSNDWYATLDMLKESCRIASSVNWSDVDLSQFQGLMESMRQADLKNWSLDQVQFADLCSSLNQFFTQTGLIHSQSNVQQNVCHGAMHPTKPSQHIGTGNLYIDSRQNLPPSVMPPPGYPHIPQALSTPGTTMAGHHRAMNQQHMMPSQAFQMRRSLPPDDIQDDFDWDSIV
The following text describes a protein:
Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane. Mitochondrion matrix.
Sequence:
MAPIYRTLHVVLRLLPSSPGPSRSRSLSTQAAPAVRMEYQDAIRTLNTLQTNANYLDQVKRQRYDPAEQLQMMRQFLERSGLQVEDLDKLNIIHVTGTKGKGSTCAFVEQILRNYGLKTGFYSSPHLVQVRERIRINGQPISKELFSKYFWQVYNRFEETNDEENPSMPPYFRFLTIMAFHIFLEQKVDLAVLEVGIGGAYDCTNIIRNPLVCGVSSLDIDHTSILGDTIEKIAWQKGGIFKSGVPAFTVSQPAGPLEVLRKRAEEIECPLYMCPDLAEYEDDGISLQLGLAGDHQKLNAALALQLAQTWLQHQGYPGVGEQKSPSRHLPPMKWPFPLASAFRPSIPMVQGLQDTIWLGRTQIFKRGPISYYIDGAHTSSSIKACVRWFREVALKEEKAGGGSVVRVLLFNATGERDTAALLKHLQPCHFDYAMFCPNISEVSGVGMADQQNFNVTLENVLTRCLENQKTWNQLNEERSCSAPWGSSLPVDALIKDSPRGSPLLLAPSSERFLNCNSLVFPCISHALQWATQGRDMEFPCLDINLLHHHPVASSGSVLLREAARIQVLVTGSLHLVGGALKLLDQSLSQ
The following text describes a protein:
Function:
Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.
Subcellular Localization:
Nucleus.
Sequence:
AYAHSSCGSNYGMQNFSPGYSHFPIHQETEVSSGFPQSVYSGNIASSVVQHQQHQSYIEGSAHYIHHSYGPEQNLSVANYNNNVASLHISQREVCHSPSSETSPGPTQTFDWMKVKRNPPKTGKAGEYGYAGQPNTARTNFTTKQLTELEKEFHFNKYLTRARRVEIAAALQLNETQVKIWFQNRRMKQKKREKEGLLPISPSTSTGSDEKSEELSEKSNSSPCAPSPASSTSDHLSASG
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MQHVRRSGVSLKTRWWSNVVKSSNKFDSLLEHMPSRSLSNLGISRFSSVAAESAAFNVSAKRELVRSGCARRPVHASCPASKVINEPAGLPVLYRNRRSTQCLMTFRSPFQLVNTASVNPQSSCFARSFASKASGSTQKQSEARKDVSTVEDPFDAPTYNIPEKPVTFTEGASYSLVILAGLAVAAGAAYGVFKELIFQPKEYKIFDKALKRIQNDGQVSVRIGSPVTGYGSESRNRAARQRIPNRIWTDEDGVEHVEVNFYIRGPHGAGKVYTEMFQDKVDKQWKFTYLIVEIKSPSPAQLMLESYVPA
The following text describes a protein:
Function:
Transcriptional regulator with a possible role in patterning of mesoderm during development.
Subcellular Localization:
Nucleus.
Sequence:
MDPERCAPFSVGPAAGPYAAAGDEAPGPQGTPDAAPHLHPAPPRGPRLSRFPACGPLEPYLPEPAKPPAKYLQDLGPGPVLNGGHFYEGSAEAEEKASKAASFPQLPVDCRGGPRDGPSNVQASPGPCLASLSVPLSPGLPDSMELAKTKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKMQEGRNPFTTAYDISVLPRTDSHPQLQNSLWPSPGSGSPGGPCLMSPEGIPSPCMSPYSHSHGNVAGFMGVPASPAAHPGIYSIHGFPPALGGHSFEPSPDGDYKSPSLVSLRMKPKEPPGLLNWTT
The following text describes a protein:
Function:
Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Postsynaptic density.
Domain:
EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium.
Sequence:
MGNCVKSPLRNLSRKMRQEETSYTVVQTSEEGLAASGELPGPLLMLAQNCAVMHNLLGPACIFLRKGFAENRQPDRSLRPEEIEELREAFREFDKDKDGYINCRDLGNCMRTMGYMPTEMELIELSQQINMNLGGHVDFDDFVELMGPKLLAETADMIGVKELRDAFREFDTNGDGEISTSELREAMRKLLGHQVGHRDIEEIIRDVDLNGDGRVDFEEFVRMMSR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
Subcellular Localization:
Cytoplasm.
Sequence:
MIDEKDKPYLEEKVKQASNILPQKIVDDLKNLILNKEIIVTRDEIDKIFDLAIKEYSEGLIAPGEAIGIVAAQSVGEPGTQMTLRTFHFAGIRELNVTLGLPRLIEIVDAKKVPSTPMMTIYLTDEYKRDRDKALEVARKLEYTKIENVVSSTSIDIASMSIILQLDNEMLKDKGVTVDDVKKAIGRLKLGDFMIEESEDSTLNINFANIDSIAALFKLRDKILNTKIKGIKGIKRAIVQKKGDEYIILTDGSNLSGVLSVKGVDVAKVETNNIREIEEVFGIEAAREIIIREISKVLAEQGLDVDIRHILLIADVMTRTGIVRQIGRHGVTGEKNSVLARAAFEVTVKHLLDAAARGDVEEFKGVVENIIIGHPIKLGTGMVELTMRPILR
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
Subcellular Localization:
Nucleus.
Sequence:
XKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPAKQSNNPPLQRSSSLIQLTSQNSSPNQQRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCCCLSLLFPHFLLFPVWRERTLRQQMHQRALGLSQWTVTAAGASSEQPGGPAVGSVHLTVSCAC
The following text describes a protein:
Function:
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
The following text describes a protein:
Function:
Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MATQARELPPKPELPRDNGDDYEDDEDDEEEEGWDDWESDGDDAAGGGGGLLCLFCSARFDSDGPLFAHCGSEHGFDFHKLVRELGLDFYGCIKLINFVRSKVAENKCWSCPEISQLEGKVPWAEDSYLKPFMEDDSLLHSLSIFDDEDDEDCEMPVETGECSAGNGRSGELQGNGLNTIIDDCSDISARFEKAVTTESNGGDNNGSLSEEQTDRQLKITRASVTAKEIKKVDDNYFGSYSSFGIHREMLGDKVRTDAYRDALLDNPSLMNGATVLDVGCGTGILSLFAAKAGASRVVAVDGSAKMSSVATQVTKNNGLLYDENAQTKQKGSPQVISVVHTKAEELDHKIVVPPNGFDVLVSEWMGYCLLYESMLSSVIYARDHFLKPGGAILPDTATILGAGFGRGGTSLPFWENVYGFDMSCIGKEVTGSSARFPVVDVLDSKDIVTDTAVLHYFDLATMKESEMDFTASLELRLPESGAAAVPGVTWCHGIVLWFDTGFTDRFCKDKPVVLSTSPFSTPTHWSQTIFTFEEPVAITNEKSVVGSSASVGSAECPAATIRSRISIVRASEHRSIDISIETTGISSDGQKHSWPAQIFNL
The following text describes a protein:
Function:
Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex; Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems.
Subcellular Localization:
Cell surface. Secreted.
Sequence:
PPVPGCRVSPVPPSLLQPVPSVGSVHPRGSQCLCVPPVLPLPTSAPSGGASPAGFCSQNVNISGGSFLLSDGLAPGSQLTYVCPSGHYPYPVGRRLCKKSGRWHPPRTTRAVCKAVRCPAPAAFENGYYTPRLISHPVGGNLTFECEEGYRLRGSPLRRCRPNGLWDGETAVCDSGEGHCPDPGNPVGTTRTGSRFTAGDEVRYRCIGKLVLIGSAERECQNNGAWSGAEPICRSAYSFDLLEDVVPALGTSFAHLLGGTNPLMQKDSSMGRRISIQRMGLLNLYLLLDASQSVSLENFKVFKESAEIMVDRLFSFEVNVSVGIITFASKPKMILSVQHPNSREVAEVFNILQRVQYKDHQDGTGTNTLAALRKISEMMSNQRMFYLNQGWEKEWKEIHHAIILLTDGKSNMGGTPKTAIGEIKEVLDITPERENYLDIYAIGVGDMDVDWKELNEMASKKDGERHAFILRDPYTLQQVFENMLDVSNFENSICGLGNVSANATDQEKNPWHVTIRATTRETCRGSLISDRWVLTAAHCFHDIEDTALWRVTVGDPGPRRSRDLEIEERIIHEGFDVHAKKHLGIPEFYDNDIALLKLKEPVKLSSVARPICLPCTLGANVALKRRPSSTCRDHESDLLNQLQIPAHFISLDNKQKNIPPIPPGSWQPVPGASCNLNPHFGLKNDDSPCKGESGGSVFFQRRSRFFQVGLVSWGLHNPCSASRGEGPVQRRPHPGGLQPRDFHLNLFRLQPWLRQHLAGDLDFLPLG
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MDCSMTSSILSANYNTILFEFGAILVTSKLLHALLRNVYQPRVFSDLLLGIVLAQFRVLSLTNAISLVFGKIGGFVFAPYLFALGVEMDPGTLLDAPTADAVVAYAGILSTSVLVTLFHMPLMKATSGVVHERSLRSFLGLAAVLSNTASPVLTRLTTDLKIAKTAVGRLAVGAGLASDMVTTMLIAVGSMIWRDAGADGSDSPIVQPVLTAAVLVVVIVSAFVSRAMAEWVGGRNPEGRRMRGFDLSLVALAAAALCWLSSALRLDVNMAAFLVGLAFPSEGRVSRLLVSKINLVLTSMVLPLYVSHVCLSLRQTTDDIEVAGLGPQTQGFRAFVMELPFPWWKILFVTVMGTLGKLTGCAAAGLLRGLGWLEALALGMLLNVKGYFHIYCAQAAFVSCFGLHCWIRRRRRRRRSNDDQQYAMQDAGIITDKSFMAIIFMVALNVAVTPMVGMGIASWARRSVQWRLMGLQHHDPSTELRLVVGLHGPQDVPTLAYLMEALRRGGGGGELAVYAVDMVQMTDQTAAAIVRGGGFDGVTVVDEEVSEMRKLIGEALDAYQAEGGEGVKVRRLLALSSFQDMHSDVCICAEDAMAALVLLPFHKAQRPDGTMDPGHFGFRLVNQKVLQLAPCSVGVVVDRGLGKGNRDGPQPVVVVFIGGADDREALTLAALMSKHPGVRLTALRVVQNATAQARWRARTSLFETKASRRGVGASSALGQEEAQMQVDDKFFAEFYRKHVAGSSRPGGGGGGHGMGYLEKHVADGAELVAVLRALQAEYRLFVVGRGRDRSSVLTEGLDEWAECLELGPVGDILASSDFSATASVLIVQQYDAKKHYKVIDEEFMPL
The following text describes a protein:
Function:
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.
Subcellular Localization:
Nucleus.
Sequence:
MRDAADPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHIHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQRTERKESTSGDKAVSHSCTTPSTSSASGLNPTSAPPASASAIPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSNQRSPSPGPNHTSSSNASNTAVVPQNSSARPPCSLTPTLAAHFNENLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MASSSESGGGSGIETIFRKELKTLPVDSTIRRSSKEEAREDDQAPSTLSTEEKAFREGVSSSEEFELGLESFFSQQEKDSAEGVVTSTTTKGGEEYIDPSGPSKETIFRKELKSLIVGSTSRRDSQEMTIIDNQGPSNDKMEEVFDFIGITSTGEVVMETSVQNQQEKVKIPDEGNSLPSAEVCVADISVTNKETIYRKELKNLKVHASDNVQEETEVLVQGLSFQEAVVGKSEFKGVSSTVGSVTELKSVAISQDRLKSLETAALLTRTEPETIHEEELALVLETVKEGQVHDGALVSREVKEARKKSKSLSTGSIEIKAKAPAVGELGSSFDRTRKRSHVPLTVLERMEKDPIVAQHFAQLESPTAETVSEFADGSKRLLSTTSRLRRTTDSVGLKYVNQYIVIKVLGCGTYGKVKLCLNTMDCKLYAVKIVHRKWLTRRSLGGTTENVGQGAMREIAIMKKLNHPNIVALHEVIDDPSKRKLYLVLEYIEGGPILGNDKWRPFPEEKARSFFRDMCKGIDYLHFNKVVHRDLKPGNLLQTLDGKIKISDFGVSHMFEQESDSMHDTAGTPAFLAPEICSGGQCQGRPADLWSLGVCLYVMVFGKIPFPAESIAEMYQSIIHKEGTTAGVLFKDQNFEGTEGYTDSHSYEGSQFENITSWNHAT
The following text describes a protein:
Function:
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
Sequence:
MINIQEQMLEPPVQDQDKNEESEEEGEEDDGDERQVEESFSKDHDRPEEPRGLEEEAAATDMQEKHPQVLNLNNEVVKMRKEVKRVRALIIRKLARQIAALKKKKGKDTEMERHQRRAARLLEEVHIMKSLPADQVTKTALQKNLNFDQVFKNPKSSLTDRAVTRIATHPQFSKKIDDIKASVKAFGVERRKGGGKAKGQRATLESAKNHEEQEKSGSRPVELPEVADGKEEVEELKDMSDSKAAKSEKKTEKRSADAAAGAGAAAAAAAAPALSSKRSLIGGPESVHSRDVIRIPNSKAAENDCNLQSATVPPPRRAEDAKTDAESDGESAGGEEKEYFDDSTEERFYKQSSQSEDSEDDFFVGKVSKVKKRRKKPKMNEVEKEPDVKKDSSGGGDKLQRELDQLESRLRPKTTTLQSVFCPSLARRKGGGGQEKSRGFGKVKGQKKVDGFTHQQEKAASSKYSKPFPGGSLPGSNTRGFASSQRGVGRGRREAPRQQDPKAGGVFSSQPALHPSWEASRRRKEQQGQILAFQGKKIKFDDDD
The following text describes a protein:
Function:
Induces an immediate fast muscle contraction followed by flaccid paralysis when injected into blowfly larvae. Has strong cytolytic activity against insect Sf9 cells and human HeLa cells, weak activity against human JAR cells, and no activity against human HEK293 cells. Binds to erythrocyte membranes and has hemolytic activity, probably mediated by oligomerization and pore formation.
Subcellular Localization:
Secreted.
Sequence:
MGKELLTFSDLTWLDSSPDTVRSAFTRQYGTTPDGIALNSEGYFGYHSPPITEQYGRPCYKQTGETKITLQDLAPPTDAILGNSIARNRGDSPITLTVSVEGKWSDSTSWSTSTETGVKMSSEFGVEGAFKMGGEFSLTVSVGKSGSSSVEKTSTSSVQVTVPPRSKVVVSMVGIMKKEKVFFEVPVTVDGSFGANFPSTVQGHYFWFMDARSCLNKTSGVIKGTIDHANVFDVSVEVGPSEPL