lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location.
Subcellular Localization:
Nucleus. Chromosome. Note=Accumulates at sites of DNA damage or replication stress. PCNA is required for localization to DNA damage sites. Localizes to the nucleoplasm in absence of DNA damage.
Domain:
The PIP-box mediates the interaction with PCNA.
Sequence:
MRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTNRDPNHGLYPKPRTKRGSRGQGSQRCIPEFFLAGKQPCTNDMAKSNSVGQDSCQDSEGDMIFPAESSCALPQEGSAGPGSPGSAPPSRKRSWSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPREARQEAEDSTSRLSAESGETDQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICSLPSEVLRHVFAFLPVEDLYWNLSLVCHLWREIISDPLFIPWKKLYHRYLMNEEQAVSKVDGILSNCGIEKESDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLPEAEACVRQHLPDLYAAAGGVNIWALVAAVVLLSSSVNDIQRLLFCLRRPSSTVTMPDVTETLYCIAVLLYAMREKGINISNRIHYNIFYCLYLQENSCTQATKVKEEPSVWPGKKTIQLTHEQQLILNHKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAERVFPSNVICKTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFASADEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECTEEAHQMTHDGYLKLWQLSKPSLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCKRVRKKTLVGGNHQSGIRGDAKGQVALLSRTNANVFDEAVRVTEGEFPSRIHLIGGIKSFGLDRIIDIWILLQPEEERRKQNLVIKDKFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVVEKYNIRIPELVQRIEKCHIEDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLPQLPHFRVESFSEDEWNLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAMERTVENIVLPRHEALLFLVF
The following text describes a protein:
Function:
Promotes matrix assembly. Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MRKHRHLPLVAVFSLLLSGIATTHAQQHGVMEVNKRDIVFLVDGSSSLGPSNFNAIRDFVTRVIQRLEIGQDLVQVSVAQYADTVKPEFYLNSYTNKRDAITAVRKMRALNGSALYTGSSLDFVRNNLFTSSAGHRAAEGVPKLLVLITGGKSLDEVSQPAQELKRGSIMALAVGSKAADEDELKEIAFDSSLVFIPAEFRPAPLQNMLPSLMAPLRTLTGTTEESKRDILFLFDGSVNVLGQFPAVRDFLYRIIEELDVKPDGTRVAIAQFSDDVRLESRFSEHQTKAEILNLVKKMKLKTGKALNLGYALDYALRNIFVRSAGSRIEDNVQQFLVLLVAGRSSDAVAGPASSLKQRGVVPFIFQAKNANPSELEQIVLSPAFILAAESLPKIGDLQSQIVSLLKAEQGSGPVSGEKDVVFLIDGSEGVRSGFPLLKDFVQRVVESLDVGPDRVRVALVQYSDRTRPEFYLNSHMDQQGVISAIRRLTLLGGPTPNTGAALEFVLRNILTSSTGSRIAEGVPQLLIVLTAEPSGDDVRGPSVVLKQGGAVPIGIGIGNADISEMQTISFIPDFAVAIPTFRELGTIQQVISERVIQLNREELSSLKPILTPSTGAGVGSKKDVVFLIDGSRNAGPEFQYIRTLIERIVEYLDIGFDTTRVAVIQFSEDSKMEFPLNAHFSKDEVQNAVRRLRPKGGSQVYIGNALEYVLKNIFQRPLGSRIEEGVPQFLVLISSGKSDDEVDDSAVELKQFGVAPLTIARHTDQEELVKISLSPEYVYSVSTFRELPRLEQKLLTPITTLTSQQIHQILASTRYPPSVVESDAADIVFLIDSSDAVKPDGIAHIRDFVSRIVRRLNIGPSKVRIGVVQFSNDVFPEFYLKTHKSQSSVLEAIRRLRFKGGSPLNTGRALEFVARNLFVKSAGSRIEDGVPQHLVLFLGGKSQDDVARHAQVISSSGIVSLGIGDRNIDRTDLQTITNDPRLVFTVREFRELPNIEERVMLSFGPSGATPQPPGVDLPSPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFASEIVDTVYEDGDSIRVGLVQYNSDPTDEFFLRDFSTKRQIIDAINKVVYKGGRHANTRVGIEHLLRNHFVPEAGSRLDERVPQIAFVITGGKSVEDAQDVSLALTQKGVKVFAVGVRNIDSEEVGKIASNSATAFRVGSVQELSELSETVLETLHDAMHETLCPGVTDVSKACNLEVILGFDGSRDQNVFVSQKGLESKVDIILNRISQIQRISCSGNQLPTVRVSVMANTPSGPVEAFDFAEYQPELFEKFRNMRSQRPYVLTADTLKLYQNKFRQSSPDTVKVVIHFTDGADGDMADLYRASEELRQAGAQALILVGLERVANLERLMHLEFGRGFMYDRPLRLNLLDLDYELAEQLDNIAEKACCGVPCKCSGERGDRGPIGSIGPKGISGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGELGEIGLDGLDGEEGDKGLPGSSGEKGSPGRRGDKGPKGDKGERGDVGIRGDPGDSGRDSQQRGPKGETGDIGPMGLPGRDGIPGSPGDPGKDGGSGRRGPAGAKGNRGGPGQPGFEGEQGTRGSQGPPGPIGPPGLIGEQGIPGPRGGGGTAGAPGERGRTGPLGRKGEPGEPGPKGSIGNRGPRGETGDDGRDGVGSEGRRGKKGERGFPGYPGPKGTPGEPGADGPPGPKGIRGRRGNSGPPGATGQKGDPGYPGPSGHKGNRGDSVDQCALIQSIRDKCPCCYGPLECPVFPTELAFALDTSEGVTQDTFSRMREVLLGIVGDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKKKSALLDSIQNLQVALTSKQQSLETAMSFVARNTFKRVRSGFLMRKVAVFFSNKPTRASPQLREAVLKLSDAGITPLFLTSQEDRQLINALQINNTAVGHALVLPARRDLTDFLKNVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDLAFILDSSEATTLFQFNEMKKYIGYVIRQLDLSPDPKASQHFARVAVVQQSTYESVDNASVPPVKVEFSLTDYGAKEKLLDFLSRRMTQLQGTMGLGNAIEYTIENIFESAPNPRDLKIMVLMLTGDMQRQQLEEAQRAILQAKCKGYFFVVLGIGRKVNIKEVYSFASEPNDVFFKFVDKSTELNEEPLMRFGRLLPSFVSSENAFYLPPDLRKQCDWFQGDQPVKNGVKFGHKQINPPHTANSSLTSKVVTTMKPVTTTKPTAIVNLPPAKPAPARPAPAQPVLAKPDPAKPAQARPAPAKPASAKLVPPQPVHVQPAPAQTASVRPAPAKPAPPQPAAAKPVPAKPAVPAQPAPPQPAAAKPVPAKPAVPAQPAPPQPAAAKPVPAKPAVPAQPAAAQPMPAQPVLTKSAAVKPASANKPVAAKPVATNTATATARPALAAKPAAAKPAATRPLAAAIRPVATKPEAPRQQAKPAATKPATTKPLARVSREVQVSEVTENSARLHWERPEPSSSFFYDLTVTSAHDQSLVLRQNLTVTDRVIGGLLAGQLYHVVVVSYLQSQVRAIYQGSFNTKKTQPPPLQAAHRASSSTINLMVNTEPLFLTKTDICKLSRDAGTCVDFKLLWHYDLESKSCKRFWYGGCGGNENRFHSQEECEKMCSPELTV
The following text describes a protein:
Function:
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MGRDYYAILEINRNAIDADIKKAYRRLALKHHPRSNSHARAAERFNLLAEAFDVLSDPRKKATYDKFGEEGLKGGIPSELGVNGAWSSGYVYHGNADETFRQFFGGDNPFADFFTGDGNEVNAAFESLRGRKEKLQDPPIERDLHLALEDLYYGCTKKIKISRRVMNEDGHTSSIRDKILTFTVKAGWNEGTRITFPKEGDQGPNNIPADIVFVIRQKNHPRFVRQNDDLFYTEHISLEKALTGFSVEVETLDGRLLNIPINDIVHPQYTKVVSGEGMPLSNSPSKRGDLIIRFITHFPEKLSAEKKKLLRGALSTKVIHSS
The following text describes a protein:
Function:
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Sequence:
MIPENEQPQLKQWALQQLENLSDADTSILGDYVIALANYDMPKSELAEMCRSQLSEFLHGNTDAFVEALMHAIETKSYMQEPLQQPQQQQQQPQQQQQFPQQQQQGQFPTPPPFPPGFDFAQMQQMGFPMPGMNVPLPSHQGFISGQQKRYNNNNNGGNKRGMSAISTPHSSTEYNRKLVVEKIPDDYCSEQAVRDFFSKFGTLNSVKVNFAGKLAEIEFSTTAEAKNAYKSPETIFDNRFVKVYWRKTDDETPENEVAEQQRLQEERQAAFEEKEQRRKEHLEKMTGILAQKKQLLEMQIEQQELLAKMGQPVTQDVEDLRNQLAEILEHEKDPTKVFKSTSAASSFAPRGRGGFRGRGARGRGAFRGRGGYHPYGAPPARENVDRTKFSLDLRPKDVLISPVTADKQEHIRAHLVSVGEYSNVAQASGDSVVVSFPDRRAAEKFFYGSADIPDVGKVDKQWFKQVKKDGEGSEVKTEDVKMEEN
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Sequence:
MIRRIQTLRTIKRPQICYTNRHQHRYNSTVTLETIASQPGPQIFVSAISDPFLNLALEEFLYDHMPARDPKSEPNPDPDALSNNRLVIYVNSPCVVIGRNQNPWREANIPVLESLRIPMIRRKSGGGTVVHDLGNVNYCFMTSNEDFSREKHSKMIMESVNAVGDAPGGPNVELKLNSRFDIVDISDNKVSGSAYKIQRHKAYHHGTMLLNSKLDVLKALLHRGENLGVIEGNGTASVKSPVTNIGMEKNLFIETVIKGFSGMYGVDFEDESGPFVQLNVIQQSDLPEKVYNTAEEMKTYHWAYGQTPKFTHVIKNDDLDVEVEFFVEKGILKDVKADSEHLQQFKYLKSVAQNEGVQYIGGKIAAFVTDERLGDWIAKTIDGSGTEKEEIVLVGKKEKSLKDMLG
The following text describes a protein:
Function:
Catalyzes the conversion of chorismate to isochorismate.
Sequence:
MPAHALSEDLKSLIDKLIQMKQVPATEPIVQLSLKTVSIPLISWLASQTLYPRIYWHGRDKVEEVAAIGACKDFKFETGVDDKALASVYEQQRMLSSNPDIRYYGGVAFDRSIESWPEFGNTRFVLPRIEFRRSANQFSLRVNLNFADNNPIDEIDLAIAAIEAVMPARPLAPPNKLTLVSRQDIPDFPHWKTLVEQVIEPKFNQDTPKVVLSRLTELEVNEQVDPWMVLACWQGRNPNSFQFGFQFSPDRTYISCSPERLFRRSQQELFTEALAGTTVRGLNQEEDVALANALLEDNKNSVENQLVRRHIVSMLTPLSQYVGAEEEATIFKLNHIQHLHRAIRAELKPGVSDFQLLQALHPTPAVGGLPRESAMTFIRQREGYMRGWYAGACGYFNKDESEFSVAIRSALIEPGKINLFAGAGIIAGSDPEAEWQELENKLATIMSILIEL
The following text describes a protein:
Function:
Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues in xyloglucan degradation. Cleaves the backbone of the 3 major types of natural xyloglucans (seed galactoxyloglucan from tamarind kernel, dicot fucogalactoxyloglucan from lettuce leaves, and solanaceous arabinogalactoxyloglucan from tomato fruit), to produce xyloglucan oligosaccharides. May be superfluous in xyloglucan degradation compared to BoGH5A (AC A7LXT7), the other Xyloglucan-specific endo-beta-1,4-glucanase.
Miscellaneous:
MISCELLANEOUS: Gut bacteria supply the human body with energy from dietary polysaccharides through glycosidases that are absent in the human genome. Xyloglucans are a ubiquitous family of highly branched plant cell wall polysaccharides present in the vegetables we consume. Enzymes involved in xyloglucan degradation mediate the conversion of otherwise indigestible plant polysaccharides to short-chain fatty acids.
Subcellular Localization:
Cell outer membrane; Lipid-anchor. Note=Cell outer membrane localization is predicted by analogy with the archetypal sus locus.
Sequence:
MKIVRYIALFGILSGLAVACTPSTSVIPNDAIRLNQLGYYPNQEKIAVVDSGKVEEFVIWDAVSGEQVFVGKSLYTAKSAWSDKTRTTLDFSAVTTPGKYILKVNGASVTFLIKDSVLSPLADAALKSFYYQRTAMPIEEQYAGQWHRMAGHPDNHVLIHPSAASPDRPAGTIVSSSKGWYDAGDYNKYIVNSGYSIGLMQSIYQLFLDYFSRQKINIPESNNHTPDLLDEMQFNLDWMLTMQDPEDGGVYHKLTTPFFEGFVKPVDCKQQRYVVQKSVTAALDFAAVMAQSSRLFASYEEDYPGFSKRALLAAEKAYAWAEKHPEAYYNQNLLNQKYQPAIATGEYGDTHADDEFFWAASELYFSTGKEIYREEAIKKAPQIYTAPGWGNTFALGIFAWLQPGRELNEADRRFADSLKTELLKYADKVIEGAEQTPFHAPYGNDAKDFFWGCLAEKCMNQGVSLMYAYLQTGKDVYLTNAYRNMDYILGRNATGFCYVTGLGTKSPKHPHHRLSASDDIEDPIPGFLVGGPNPGQQDGAFYPTASPDESYVDTEDSYASNEVAINWNAALVALASSLDALAVYSVK
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals.
Sequence:
MGCYQSRVQVEDKTNEQLDKYLVQAGKEGLLDFRILLLGAGESGKSTVVKQLKSIYKIQVDDDELHSYAVNIHKNTVLCMQVLLEAGETLGIELTDPETKKRAINVKSFQFEPEVKQMPVSIGLDIEELWRDEDIQKIWDRRSEYWFLDATPYYFENIQRFLDDDFVPTEEDCIMTRVRTTGISVTEFDEGPVHFRVVDVGGQRNERKKWIHCFDDVKALLFVVNLAGYDQVMFEDPSQNRMQESLTLFGQICNNPIFSETPTFLVLNKKDLFEQMIQKTDLSKCFPDYKGGSDVKTALEFIQMKYQQKIQESNKPLHTFHIAARYKKDIKYTWEEAKGILLEENKKVLMKATKDLKKSSKQSSKSSLGNSTQNNSNNNNNNNNSNNNNGQTTIDGATAKINS
The following text describes a protein:
Function:
Catalyzes the oxidative decarboxylation of the C-terminal cysteine residue of mersacidin to an aminoenethiol residue.
Sequence:
MSISILKDKKLLIGICGSISSVGISSYLLYFKSFFKEIRVVMTKTAEDLIPAHTVSYFCDHVYSEHGENGKRHSHVEIGRWADIYCIIPATANILGQTANGVAMNLVATTVLAHPHNTIFFPNMNDLMWNKTVVSRNIEQLRKDGHIVIEPVEIMAFEIATGTRKPNRGLITPDKALLAIEKGFKERTKHPSLT
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Membrane.
Sequence:
MNGFAAHGLDEDAFAEKSGLTGGLRTFDAFPKTKPSYTTPSRRGGQWTVLILIICTIFSITEFRTWLKGHETHHFTVEKGVSHDLQLNFDAVIHMPCDALHINIQDAAGDRVLASEMLKKEPTSWKLWMDKRNYHSSEYQTLSDSRGDEERVAAMEEDVHAGHVLNELRRNGKRKFAKGPKLRRGDVVDSCRIYGSLEGNKVQGDFHITARGHGYRDGREHLDHSAFNFSHIITELSFGPHYPSLHNPLDKTIATTEFHYYKYQYFLSIVPTIYSRNQNLRLDALPSSSSARSNKNLIFTNQYAATSQSDAIPESPYVIPGIFFKYNIEPIMLLISEERTGFLNLLIRIVNTVSGVLVTGGWVYQIMTWLGELRRRRRGGEKSEGYLHGKLEEE
The following text describes a protein:
Function:
Regulates clathrin-mediated endocytsois of cargos such as transferrin probably through the association and modulation of adaptor protein complex 2 (AP-2) (By similarity). Has a role in ciliogenesis. Required for proper cephalic and left/right axis development (By similarity).
Subcellular Localization:
Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKMFESLDSSATKSGRDLWAEICSCLPSPAQEDVSDNAFSDSFMDSHPAGESHTAAADSAVQPAGKPWAPLHDSEVYLASLEKKLRRIKGLNEEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDERTLEHFKRWLQPDKVAISTEEVQFLIPPESQAEKPEAGDKPAAAEQ
The following text describes a protein:
Function:
Plays a role as a potent and selective agonist of pth2r resulting in adenyl cyclase activation and intracellular calcium level elevation.
Subcellular Localization:
Secreted.
Sequence:
MALSLPPRPALLFLVLMSVTLMASAFPQPQLRPLQSNLPAIGQEDSKGEQWEVVYPSISLRDWSIQMLTAPDFGAAKTGREQLVADDWLPLSQSQMEEELVKGWTGDWPSRVGHQQKRNIVVADDAAFREKSKLLTAMERQKWLNSYMQKLLVVNSK
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVKRSIEPKHLCRGALPDGVPSELECVTNSTLAAIIKQLGSLSRHAEDIFGELFNEANSFYMRMNNLQERVDLLAIKVTQLDSTVEEVSLQDINMRKAFKSSTIQDQQVVSRNSIPNPVLELYHRGDKPPPLNILSPYRDDKKDALKFYTDPSYFFILWREKMLQATEDKRKEKRRQKTSGSGQTHSDQTKSHSRQALLRSPLLSSEQQKQVEDPSREVKKVRKARNRRQEWNVMAYDKEFRPDARFTPSPYHGMSSEGSLSPDNRSVASDMGEHSYPGSPSHPAQQMAVSSAYSAADGKEHLMAPSHVQTQSLDRGYRPAPSSAAPPGRQTIGRVQTSHGQPITDPALNGPRPLQTKDYSGQQSQHREYFVPPAPPPPPPLIPSAQTAFDSPTGPSSAPASAMPSLSQTYSQSPPTPALPASYTPSPTHPPPAAPPPPPPGPPTHPHPHPMPAASVEAPVVPRKGQVPLIPMSDARSDLLAAIRRGIQLRKVQEQREQEAKKEPVGNDVATILSRRIAVEYSESDEDSELDENEWSD
The following text describes a protein:
Function:
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
Domain:
The PXY motifs are required for binding WW domains. PXY1 is required to promote transactivation of beta-globin and for hyperacetylation of histone H3, but not for binding to the HS2 promoter site.
Sequence:
MSPCPPQQSRNRVTQLPIPEPGEMELTWQEIMSITELQGLNAPSEPSFEPPAPVPYPGPPPPPSYCPCSIHSEPGFPLPAPPYELPAPTSHVPDPPYSYGSNMTVPVSKPLTLSGLLSDPLPDPLALLDIGLSAGPSKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSLMPNSLTHPNYALPPAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTDLYRDIFQHLRDEAGNSYSPEDYALHQAADGAIFLVPRGTKMEATD
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Note=Localizes to the A-tubules of DMTs.
Sequence:
MAQIIDLVPWDECSAHLYASPAVLLPLERVRHPLAGVKHQLYHPALPSLRRMDMDTVKGCLSDEHCQSSTYFSKDDFNKAHFTLLGVPNKPLQCLDFTATGQKLCHKYRGGKMIPIAPGINRVDWPCFTRAIEDWSKFVSRSEEFKLPCANKRVEGFSGYAVRYLKPEVTQNWRYCLNQNPSLDRYGQKPLPFDSLNAFRRFGSHYSRINYLTPWH
The following text describes a protein:
Function:
Structural component of the ventral disk involved in maintanance of a domed conformation of the disk required for proper attachment (By similarity). May have a role in immobilizing the microtubules between cell divisions.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Localizes primarily to the overlap zone of the ventral disk microtubules, the disk edges and the plus ends of the disk microtubule spiral array (By similarity). Localizes throughout the spiral of the ventral disk and to the lateral crest surrounding the ventral disk (By similarity). Median body. Localizes intermittently to the median body mainly in prophase (By similarity). Does not localize to the microribbons or cross bridges of the ventral disk (By similarity).
Domain:
Shows an alpha-helical coiled coil structure (30 repeating heptads).
Sequence:
MSEAMVFSKIDEYTLFMSRSLQKSLKTFAEQVMALIYQYKDTLVEDRLALTNTLDEAVQILVDSGKEEADKLGFNIYSAVSRYISEIWASQSGQTTAAPPATDIDGLHRQLVALKNSLGQNAELYEQRCQLQAELRELQEFSENPAAAVEEIMQLKAQIDELKYGASNHNALVQEKRDLERHLADLRLSRQDTNSRLPQEIDRLRAEIEDEKRNLPHMDDLQRQRDELQRQLDTIRRRGNTSGVMAEIENIQRQIDDANSSASSEHELRMLRAEVETLRAQKSIVTRLEAENADLRRELQDIRGRAQEMSASQRYSANQAQELQEKAMQAEELLQQKIELRRQLHEALERADAGEAALRDKRRLEDEIKGLQLRLTENDFTKERSILRNEIQAKTTEIDTLISDRRALETKLLNKEAEVDQLLYEKQLLKTELNSYRGTNEDIDKLTFEKRQLVEELNDLREKTIKYDQLAREKAALETELKENSYNFDQLLEQKQQMRSDLNALREKAADYERVDRELRLKDKELEEKNAEIERLLEDRRVMRTELLHSKESATDVDSLIQEKRLRDRELAHLRDRMSEYERVVEERIQKEKENNLLKQRITELEQQQRTATVRETEMSALREKANELDGYNRERQAREHEINMLRDKALESDKLRQDNRVMAMELTELREKVQLLEKLQYEKRARDVEMLELRHKAMDVDTLVEEKQRLEMRLAELKIKVNNYDQLADDKARLQEQLKEMSDKLIEFEMIMDDNRRLKLQVKELDLKTANMEKLYEEYKKLEDQLKATKAMTSTGMGVSAASPAFYKTKSMRLTQQNNQMKNTTDNLLTRDIPKLIDKLIERPAGTTTMGRSGKF
The following text describes a protein:
Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Sequence:
MAAVWNRSGRAALAARCRGGVWLGLSAVCAGLARREMRTSEVLRRGGISTLFQRRRQTPHNLPYQLVTKAHAPGDGDILAVPEHIARPPYIVDPNVALPDVFHDDVPILPAADRPALRAAGRLAGQTMAHACALAVPGCSTAELNAQVHAFIVGHDAYPSTVNYMAFPAATCTSVNNCIVHGIPAHNVVLQEGDLISIDITVYFQGHHGDLCRTVLVGAAQDDVAPRLVQTAREACEAGIAACGPGQEYSDIARAIETHVEKQGFFVSPYFTGHGIGKHFHQAPGIHHETQVDSASDLRMLPGHVFTIEPIIHETSNVEFEILSDNWTALTMDGSRTSQFEQTIMITETVGKGPIAMAMAATQALVDVARLNLMSRPASIGMS
The following text describes a protein:
Function:
Required for survival at high temperature during stationary phase.
Sequence:
MAVGGNNWSMWLRMSRVHLRQITKSLDRTLISLSHGNFSHQYNRNIFVTWWKSLFEASTAFRRASGLTVSPLTRRGIARFDHFRPVPNVSKFASFPRVPKGAPRGLFTNWNMTTSKRLLGQRAYSTSSIKFTQEAVNNMTISLRCFFNSLGGLNQCSHSNSCKAYQNASNVTSKQDHVQPVALKKLSQKDINFIRNLELFKIMKTQNEVVDETSAYYMEKPGSYIEFTISEFNVNGTFSAPLSFLDPSLLADLDEMIRNYKYELKSIYSSVDMILQNYGSLPITFHRNKIRIHFPNSTVVETEKLIAGLNIATGVIYADTSPDISLEGTNLNALVNVDNSGSVWSFVKEPSFPSRSAFSPILSDASYDTYELV
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MVQVVSQENFADSIASGLVLIDFFAEWCGPCKMLTPVLEALAAELPHVTILKVDIDSSPRPAEQYSVSSIPTLILFKDGKEVERSVGLKDKDSLIKLISKHQ
The following text describes a protein:
Function:
Has a role in meiotic chromosome segregation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLTSKHEFSLFLNTPAINSKSEKEVISEGPLTTSNEIDVTFSESFSSHLINLRRVPSVNSIIEQEKKGLTKISPSILNQNIAYKEKRQQLFSVLYEETVGYVSMDTLCIAISLLDRCFTVKPTIPTTSFKIYAIGCLFIAFKLTSDYSVAKKSFCENLAPSLSTKNLEKYEKIVLALLNFDIYVISLPSVESFLTPLIFQHVFFKSLPSESCDQMMVEWQYLLVEVMKDCQFIEYRPTEILCASFWVLLEIIWPSAFDFKPFQHLCSLPTNGSADETYIKHSNRFHDLIISIQRIADMLA
The following text describes a protein:
Function:
GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
Subcellular Localization:
Golgi apparatus.
Sequence:
MGLTFTKLFSRLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLEWLSNNIASKASMRVKVKEFGCLTWSFWGG
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MMDWYAIQTYSGSEQSVKKAIENLANDHNIRDRIQEIIVPTEDIIEVSKKSKTKVTERSLYPGYVFIKVDLDTVLWHKIQSLPRVSRFIGENKKPTPLSEADIGHILEKMNNRAAPKPKIFFEQGEVVRVVEGPFANFTATVEEYDVEHRKLKLNVSIFGRNTPIEILHSQVEKII
The following text describes a protein:
Function:
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MSFHGLVNLVKSVQAELMNVKATPGSILIGSLSLIGLLTVAKYQLSFMNLLFCFSPLSKPFKISLGSLKGNLFLKQKDRQGGEKDQKTPATKNSSSWAIITGPTNGIGKEFAIELSKAGFNLFLIGRNPNKLTSLQDELMKVNPTIEVEIETIDLSDNNPGGRGEEKDSGSVAVQEQTQSKEWKKILEKLKQISSRSNISILINNAGLSHSEPIEFQMNDLDQDINSLLNVNVFSVLYLTKLVLPFMLPYKKGLILNVGSFSALIPTPLLSTYAGSKGFLYTWSQALGTELEPRGIDVKLLNTYFVASEMSKIKKASFLIPTPNAYVKQVLNNLISTNSKPFITTGYFSHSLLEFFLDHFGSLKFWLKFNLNMQRSIVKRIQKKKQRIQQQQSKN
The following text describes a protein:
Function:
Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity).
Sequence:
MTRRRPERRRDLLGLLGETPVDLSQANDIRALPVNELKVGSTQPRRSFDLERLSELAESIRAHGVLQPLLVRSVDGQYEIVAGERRWRAAQLAGLAEVPVVVRQLSNEQARAAALIENLQRDNLNVIDEVDGKLELIALTLGLEREEARKRLMQLLRAVPGDEHEQLDQVFRSMGETWRTFAKNKLRILNWPQPVLEALRAGLPLTLGSVVASAPPERQAELLKLAQNGASRSQLLQALQTPSQTSAVTPEHFAKVLSSKRFLSGLDTPTREALDRWLARMPERVRQAIDEQS
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKLMIKKSRSLMGEIKIPGDKSISHRALIFSSMGEGESIIKNFLFSQDCISTMNCLRALGTSIEICENVIKVKGNGINGFREPENVLDAGNSGTTIRLFTGLLSGLPGIFSVITGDDSLRRRPMKRVVEPLLGMGAKIWGRNGGNNPPLAIKGEKLKGRDHTLSVASAQVKSALLIAGLLADGETSVTEPSLSRDHTERIFQYLGLPLIRNGLTLKTHGIEGFKNKDFNIPGDFSSAAFIIAAGLLVEGSKIVIKNVGINPTRIGMLSVLKEAGAKIQILNQWEEGGEPIGDLIVEFSILESFEVRGEIVPKLIDEVPILAIIATQAKGKSVFKDVGELKVKESDRIKAVVDGINKMGGKAEIIDEGFAVYGPTKLNGNEIETYNDHRIAMSFAIAGLLADGETIVESNSISISFPNFGETIKKLGGNIIEL
The following text describes a protein:
Function:
Transcription factor which binds the E box motif 5'-GCAGGTG-3'. Involved in migration of the gonadal leader cells; distal tip cells (DTCs) in hermaphrodites, and linker cells in males. Positively regulates expression of alpha integrin ina-1 and ADAMTS protease gon-1.
Subcellular Localization:
Nucleus.
Sequence:
MAKKPRVTKLNTDRRSRANERERQRVSEMNGMFDVLLNLLPPSHFKTRLSRVQILREATSYIIRLHNFLIESSNSDIDAITVFPHIFNGERKSNKDAIRRPMKLKQGGGVAAFISRHELPPLQLPNPVIPILKPTSVPVWPQTNVYIAYF
The following text describes a protein:
Function:
Is likely an oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinol.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVIIVGGGMAGATLALAISRLSHGALPVHLIEATAPESHAHPGFDGRAIALAAGTCQQLARIGVWQSLADCATAITTVHVSDRGHAGFVTLAAEDYQLAALGQVVELHNVGQRLFALLRKAPGVTLHCPDRVANVARTQSHVEVTLESGETLTGRVLVAADGTHSALATACGVDWQQEPYEQLAVIANVATSVAHEGRAFERFTQHGPLAMLPMSDGRCSLVWCHPLERREEVLSWSDEKFCRELQSAFGWRLGKITHAGKRSAYPLALTHAARSITHRTVLVGNAAQTLHPIAGQGFNLGMRDVMSLAETLTQAQERGEDMGDYGVLCRYQQRRQSDREATIGVTDSLVHLFANRWAPLVVGRNIGLMTMELFTPARDVLAQRTLGWVAR
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKDRLFVWTILFLLFWHEGFSIRWLSLQHSTLHWNLSSVSNNPGRGIRSGARSPCGVARRRYGLAKLQAKLCRSTMEAMPHVQKAAVLAADTCQTVFKDRRWNCSSITTAPYLTPDLTRATREQAYVYAISSAALTYTMARACASGTLYHCTCAGKPDEPPNSNFQWGGCGDNIHWGVYFAKRFIDNVEKNNVDKSRKRRKGYEYDEDRKSKLVREEIAAVNLHNNRVGRRIIRESIQTQCKCHGVSGSCNVKTCWKGLPPMFEIGRKLMKQYTNAKEVSRYYVEGNLGKTRISDHLLYLSKSPDYCTKDVKLGSFGTVGRKCNVTTNETNSCRQLCCGRGYRTLVEEKLERCHCKYYNCCYVKCKICRTKTQIYECG