lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MASNAAAPFWRSAGMTYITYSNLCANLVRNCLKEPYKAEALSREKVHYSISKWADGKPQKPTLRSDTPED
The following text describes a protein:
Function:
Endonuclease responsible for the single-chain interruptions (nicks) located at specific positions in the minus strand of the viral genome.
Sequence:
MATNTKYKRDAISIMRDGIKSRYSKDGCCAICGSSEDLELHHYHTISQLIKKFAKELQLDFTDENIVLSNREAFYKKYEHELVRDVVTLCQHHHQLLHKVYTKEPPLFSANKQKAWVQKQKDKIQNPQEKTQVKTETKSGFARFL
The following text describes a protein:
Function:
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRLIFQECSVIFTLVNLVGALSQSFGQKDAINTTIINFNNEKMQITWATSKLFSGKNVSFYYTFEEGKQKSWKTCPTYLLTQGYNTGCLFKTDGYTLAFSIMNTNGSEELFSKRLKSDFYIKPNRPENVTFFWKDDTVTVTCNKPEKGVKCLRLELQYKSKYDKGWQSRTSKCCRVGEQGFDPRKCYSFRVRLKRIVPSCNVVDYSSDWEAETFWMNSTLLDSCDDEIKTQSNTVILLSCLMTLLLMVFILLILLCKWQRLQKSVMPTIPDPKYVFTDLFNNHNGNFQEWIDKTDHAVVQTKLEYEEPECIIEEENQQIDKKSDNQEPREKIFSFSQLTGNNSPKAAHNACLVPTFNNMVSFAGLQNVVNDDTYVML
The following text describes a protein:
Function:
Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGWFKGTVKAVPSGDSLVIMGTAKEGIPPEKSITLSSLMAPRLARRDTSDEPFAWDSREFLRNKCIGKEVTFKVDYAVANLNNREFGSVFMDDANVALAVASAGWAKVRQGAEKSPFIEELLKAEEQARQQGLGIWNKVRNGGAGERSIRSIPPSAIGDTSTFDARALLESSKGKPLRAFVEQVRDGSSFRVYLLPSFQFVQVHLAGVQAPSMGRRVAPASAGGGGDAKDAENGEAGEGAAAPTTLTTAQKLAASTNLEAPEEWAREAKHFTECRILHREVIIVLEGTDKFNTLFGSVKYKETVDLALELLQQGLAKYAEWSANMLEEDEKRRLKAAELQAKKDRLRLFAGFVPQINTKAIKNDVFTGQVIEVTSADCIVVADDAIPLGRPNWDRRVNLSSIQAPKRTDAEARFREAKEFLRSRLIGQQVRVFMEYSRTITTDSEAGGTRLLEFGSVFLSSAPQGAEVFEPPLPGQPEGFNVAELVLANGHAQVVRHRDFDDRSHYYDNLVAAERKSQKPGKKGTPPSAPAHINDLTMALLASKARQFLPFLQRARRLSAVVDFVLSGHRYKLFVPKETCLIFFSLSGVRCPGKGEPYSDEALAFMRRRVSQRDVEIEVETADRTGTFLGSLYEGKVNVGIGLLEAGLAKLQPGFAERITDGHLLMQAEEHARTQRLKIWENVSDDGESEKQSTDKPSKQEVLQVQVTQVLAGGSFYVQEVSDTRASSIQQQLESLSLSEKAAPAGFTPERGQLVLANYDGAWYRGLVVNAPKAGKGEYEVFYIDYGNQEVVPLSQLRPIDPSVAGTPGLAQWCSLAHVRVPGEGEEFCEEAAEFICTSKTMMAKVEGRDASGGKVKGQGSGTRLIVTLVDVDTSMSVNAGLLEAGLARVDKAGKWDSKEKRAALEVLAEHQEKARKARLNIWQYGDVDGSDDEDKGPGARRGGRK
The following text describes a protein:
Function:
Transcription factor. Involved in negatively modulating apoptosis in germline and somatic cells, acting in partial redundancy with transcription factor egl-38/PAX5, probably by directly regulating transcription of apoptosis regulator ced-9. May bind to the DNA sequence motif 5'-GTAACG-3' in regulatory elements.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MFTKTFSNNYMTSSQSAYCNLQQYHDSRVCLLKCCRVQKVDPYFPRIALNSATSYPTVSGTVSLPKAETVEPDLWIKSFKGNEDPLLSDGSHTGVNQLGGVFVNGRPLPDTIRAQIVEMSQHGTRPCDISRQLKVSHGCVSKILGRYYSTGSVRPGVIGGSKPKVATPRVVECIAGYKRANPTMFAWEIRQKLIEDQICGEENVPSVSSINRIVRNKSFMAQLATPTSVTPSVARPSSATSQNQRSPPRGVQQHMQQSTSVQQLQQFQLTSAATVNSLISRPAFAIPGTTHSINGLLGTFPHSSLLDDKFTNLSTHSADMSLVYPTGLVGEHDWAMRTPMVILPQNYCGQL
The following text describes a protein:
Function:
Probably shows dehydratase activity.
Miscellaneous:
MISCELLANEOUS: Contains a dehydratase motif that is predictive of enzyme function.
Sequence:
MTNRISRLKTALFANTREISLERALLYTASHRQTEGEPVILRRAKATAYILEHVEISIRDEELIAGNRTVKPRAGIMSPEMDPYWLLKELDQFPTRPQDRFAISEEDKRIYREELFPYWEKRSMKDFINGQMTDEVKAATNTQIFSINQTDKGQGHIIIDYPRLLNHGLGELVAQMQQHCQQQPENHFYQAALLLLEASQKHILRYAELAETMAANCTDAQRREELLTIAEISRHNAQHKPQTFWQACQLFWYMNIILQYESNASSLSLGRFDQYMLPFYQTSLTQGEDAAFLKELLESLWVKCNDIVLLRSTSSARYFAGFPTGYTALLGGLTENGRSAVNVLSFLCLDAYQSVQLPQPNLGVRTNALIDTPFLMKTAETIRFGTGIPQIFNDEVVVPAFLNRGVSLEDARDYSVVGCVELSIPGRTYGLHDIAMFNLLKVMEICLHENEGNAALTYEGLLEQIRAKISHYITLMVEGSNICDIGHRDWAPVPLLSSFISDCLEKGRDITDGGARYNFSGVQGIGIANLSDSLHALKGMVFEQQRLSFDELLSVLKANFATPEGEKVRARLINRFEKYGNDIDEVDNISAELLRHYCKEVEKYQNPRGGYFTPGSYTVSAHVPLGSVVGATPDGRFAGEQLADGGLSPMLGQDAQGPTAVLKSVSKLDNTLLSNGTLLNVKFTPATLEGEAGLRKLADFLRAFTQLKLQHIQFNVVNADTLREAQQRPQDYAGLVVRVAGYSAFFVELSKEIQDDIIRRTAHQL
The following text describes a protein:
Function:
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (By similarity).
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion.
Domain:
The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation; The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB.
Sequence:
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
The following text describes a protein:
Function:
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (By similarity). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules.
Sequence:
MSYKPIAPAPSSTPGSSTPGPGTPVPTAGSVPSPSGSVPGAAGPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART
The following text describes a protein:
Function:
Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane.
Sequence:
MIDFYLMLIPGRMTKSYFKQEHDLEKRRAEAARIREKYPDRIPVIVEKAERSDIPSIDKKKYLVPADLTVGQFVYVIRKRIKLSAEKAIFIFVDNVLPPTGAIMSAIYDEKKDEDGFLYVTYSGENTFGDLTSH
The following text describes a protein:
Function:
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of penicillin, the world's most important antibiotic. AatA catalyzes the exchange of the alpha-aminoadipyl side chain of isopenicillin N for phenylacetic acid to yield penicillin. This step occurs in the peroxisomal matrix and the penM and paaT transporters are involved in the isopenicillin N and phenylacetic acid import into the peroxisome, respectively (By similarity). The penicillin biosynthesis occurs via 3 enzymatic steps, the first corresponding to the production of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) by the NRPS acvA. The tripeptide ACV is then cyclized to isopenicillin N (IPN) by the isopenicillin N synthase ipnA that forms the beta-lactam nucleus. Finally, the alpha-aminoadipyl side chain is exchanged for phenylacetic acid by the isopenicillin N acyltransferase penDE to yield penicillin in the peroxisomal matrix (By similarity).
Subcellular Localization:
Peroxisome matrix. Note=The unprocessed preprotein is translocated inside peroxisomes and regulates its self-processing.
Sequence:
MLHVTCQGTPSEIGYHHGSAAKGEIAKAIDFATGLIHGKTKKTQAELEQLLRELEQVMKQRWPRYYEEICGIAKGAEREVSEIVMLNTRTEFAYGLVEARDGCTTVYCKTPNGALQGQNWDFFTATKENLIQLTICQPGLPTIKMITEAGIIGKVGFNSAGVAVNYNALHLHGLRPTGLPSHLALRMALESTSPSEAYEKIVSQGGMAASAFIMVGNAHEAYGLEFSPISLCKQVADTNGRIVHTNHCLLNHGPSAQELNPLPDSWSRHGRMEHLLSGFDGTKEAFAKLWEDEDNYPLSICRAYKEGKSRGSTLFNIVFDHVGRKATVRLGRPNNPDETFVMTFSNLDTKSAIQANI
The following text describes a protein:
Function:
IMP-specific 5'-nucleotidase involved in IMP (inosine 5'-phosphate) degradation.
Miscellaneous:
MISCELLANEOUS: Present with 1590 molecules/cell in log phase SD medium.
Sequence:
MSSRYRVEYHLKSHRKDEFIDWVKGLLASPFVLHAVSHEGDYNDDLATTQRVRSQYADIFKDIEGLIKDKIEFDSRNMSQDEIEDGASSQSLNILGQSRLNLLVPSIGTFFTELPLEQAFLWEDSQRAISARRMVAPSFNDIRHILNTAQIFHFKKQENLHNGKVLRLVTFDGDVTLYEDGGSLVYTNPVIPYILKLLRCGINVGIVTAAGYDEAGTYENRLKGLIVALHDSTDIPVSQKQNLTIMGGESSYLFRYYEDPEEDNFGFRQIDKEEWLLPRMKAWSLEDVEKTLDFAERTLNRLRKRLNLPSEISIIRKVRAVGIVPGERYDEASKRQVPVKLDREQLEEIVLTLQNTLESFAPSRRIQFSCFDGGSDVWCDIGGKDLGVRSLQQFYNPESPIQPSETLHVGDQFAPVGSANDFKARLAGCTLWIASPQETVNYLHRLLETD
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MAPVVPRSGDAIFANFERVNAELFTLTYGAIVRQLLTDLEEVEEVNKQLDQMGYNIGIRLIDEFLAKSNVTRCVDFRETAEVIAKVGFKMFLGVTASVSNWDTEGTCCSLILEDNPLVDFVELPDTCQGLNYCSILSGVVRGALEMVSMKTEVTWVRDMLRGDDAFEFQVKLLKQVPEEYPYKDDE
The following text describes a protein:
Function:
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
Sequence:
MQGNRENSKGSHNEESVSSTLGKEQTGQGKSNIIENIKVDKNKKIIYLYDVAITEDELEELLKSKRKEQKNETCNYKKVCYNYEMNGKNVEHNNVVEEKGTLCNSNVDSKCSWIDDNHKVISLMRCQKYIIENRINKDIDIPHNNTINALFMDYYHLVMAYTYFKQNKHEDKSIFEVYFRKCPFNGQFAILAGVYEVIKYINCFRFTKAQLDFIRKKMSSYNDIDSFVQYLEKISGNDLCIYGMEEGSVVFPNEPLMVIEGPLLICQILESVILNLMNYPTLISTNSIMYKFSINNKTLAEFGCRRAQGPDGALSGSKYSFCGCDFTSNVYASYLYDIPILGTMSHSFISSFHNTEKLISNLLDNHDFVSIINKNKNIVHKLYDCKYTNESELIAFSAFAQINPKNFICLIDTYDTLKSGIYNFLIVALSLYEINYKPIGIRIDSGDLRSLTNECKNIFNDISQKLNVPFNQLKICVSNDINQKIINYLNEEQNHIDIFAIGTNLITCQSQPSLGLVYKLVQINNAPCFKMTNENKKSNLPYQKNVYRIYTDQQFATLDYIQLYNEQPPILNQQTISINIHDEWKQTIIIPKKIEQKLCLIWKYGKSLITFKNIYDLKKYTQSEINNFKNEHFKTVSPVPYPVLFSDTYHKVYKDLLIKNSHINQ
The following text describes a protein:
Function:
Component of the cell division machinery, which is probably involved in the stabilization of the divisome under certain stress conditions.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Localizes to the division septum. Localization requires FtsQ and FtsN.
Sequence:
MNRLIELTGWIVLVVSVILLGVASHIDNYQPPEQSASVQHK
The following text describes a protein:
Function:
Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'.
Miscellaneous:
MISCELLANEOUS: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes.
Subcellular Localization:
Nucleus. Note=Actively transported through the nuclear pore complex (NPC).
Domain:
Homeobox domain 2 confers nuclear targeting.
Sequence:
MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MHRPRSSWPNLVWDHSFPHHVLTQGKYTTIPYRTYICLQGNETSLKEAEWAIRNDNPRALVKSYNKELWTFTLQEGVTPPSALDRFQLTETTTGVFLPSTTTPSSLTMTKQLTPPGYVALMLAIEAMIQEALKRDDHYVPFGNNLILPVTGDLLHLDARLTPGGDLLLQMYQQETEWEMFGKRKRDVANEIVGTKVVVAPTLVEGVVENSTNQIPDNLPVLLEMLDCLCSVRLRAKKQWTAVRIDTEVLLWPTELLFVDRKSATGKLEDEGKDALLWTEDILDSVFEATQLIRRGESGVNTNESTAAQPQPAQNGTNSMAPAAGTTNATTQRNEENKQIYPTPPEAPKRILPGILLERATAPAGGWGELDEELFGGDEVTEADFNFFDDMGGDKNDTDGDNDNGNDNDNDKADAMDVDVKEEAKKEEMIKKETKEEVPVKEEVQEEEPDESATTAALLTNNPAEEKAVVHGVNDSSTVNGAVDAAVSATVVSSVPYLPSDFDQLIVNPAEQRTFALVEFNREAEQRLNDKYAAGGRFFVPDDSSSDNEGSSDNTGDSSDSGDGSESVPRDVKRQKVDEGTLSDQTDEPEIDAKQLHQQWSAILNYNHDDKPAKKIDSSNDTTNSDGNSNNSNYEEAVQRLAEQVVWDNSCYKGLVPQENYYRPPSARFVKVVEQVFGDTSKRLSLIDFAKMSDKGGQQQPGVGMPINAAAGTAGGGPGTPVTVSNASGVPSGSSGAQASQMGALAVGSALSPSRGATPQPEGSSPETRPSNWTPGITSQVNSAASSPVPLQQHQQQQQSFSPMSPQTPAQAPVPSANSFANAANAAPTQRLATPMYSFMRGGSLIKAQPPILRFWSTFGLSPRNGPKPLTLTLIYPSGTAIGDAAAAFLISFKMCYEGCGFGLVTLGGSNGTGVVSSDYKNLDVSREGVLLVSNPYNDVLGFLNLAKAAAAGSKTATSTSTILTLPCSIFASYTALRAPSAMLLAALCRNLYDHLPPTSTKRRYGSVIQRQAPACVISKPVPPFINFKLLANTPDSVINEDSLLHVAYAASNRWITCAWSDQWGELAKVKVFCLQSESGPLRTLEEVCTEIWETTLQLNGSTDVRSVAVAKLGGMLDDELAMWLRVSSVTRGRRITPFFLVVDNRPSMVVTGSDDGSKGGNVAGGPAPAPPTGAAGAASTGSAPMSTPFRDTDSPDIYNHVTTPSVGEDKIDYDDMSIVDVHDEIHSVTLNHRQPLTMHSTRLGLATGYLVKTSPLNPNQLLVFSLTFVNCPCVVMHVAMKHFLRQYRNLISLAATTGVCDPEYAIVPWHVEAVDKMMRLVEEL
The following text describes a protein:
Function:
Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.
Sequence:
MVLTTTSIRDSEESLHCTFASRYVQEPLPKFKIPKKSMPKEAAYQIVNDELMLDGNPRLNLASFVSTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMLAHLFHAPVGDDETAVGVGTVGSSEAIMLAGLAFKRKWQSKRKAEGKPFDKPNIVTGANVQVCWEKFARYFEVELKEVKLKEGYYVMDPAKAVEIVDENTICVAAILGSTLTGEFEDVKLLNELLTKKNKETGWETPIHVDAASGGFIAPFLWPDLEWDFRLPLVKSINVSGHKYGLVYAGVGWVIWRSKEDLPDELVFHINYLGSDQPTFTLNFSKGSYQIIAQYYQLIRLGFEGYKDVMKNCLSNAKVLTEGITKMGRFDIVSKDVGVPVVAFSLRDSSKYTVFEVSEHLRRFGWIVPAYTMPPDAEHIAVLRVVIREDFSHSLAERLVSDIEKILSELDTQPPRLPTKAVRVTAEEVRDDKGDGLHHFHMDTVETQKDIIKHWRKIAGKKTSGVC
The following text describes a protein:
Function:
G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPAHLAEASPDSSHPSGATQTLEASPVLCTEVVTFTQVVEREEWGSFYYSFKTEQLITLWVLFVFTVVGNSMVLFSTWRRKRKSRMTFFLTQLAITDSFTGLVNILTDIIWRFTGDFMAPDLVCRVVCYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLVMIAWSLSFLFSIPTLIIFGKRKLPNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYAIVIRTIWIKSKAHETVISNCSGGKLCTSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFSLLPDTEERFYASVIIQNLPALNSAINPLIYCVFSSSICFPCREQTSRGSRKTFRERTQRHEMQVLSKPEFI
The following text describes a protein:
Function:
Component of the larval cuticle.
Sequence:
MKFFIAFACLLAVALANEDANVLRAEQQVNVDGFAYAVELDNSVNVQQKGDLNGEEWVVKGSQSWTSPENVPVSIQYIADANGYQVVSANPPLPTPPPIPEAIQRSLEYIAAHPPSQ
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination. Involved in pilin antigenic variation (By similarity).
Sequence:
MSEYRVNHEPVFMLASSPWRESSLWVEAFSRRYGRVALLARSARKRQSELRGVLVPFVPVSVSWYGSQELKTLHRAEWVGGWRQPQGRALFGGLYVNELVLKLTAREDPVPELYDALAEVMEAVCCKAAYIDDLRRFEWRLLNLLGVAPDLNRDGDGGTIAAGGTYLVRPETAVFPVGKGFAVPPHAAGVVAPGQSLIDLREGSFRTAESLQQALKITRLFIRHLLPEGLKSRQVLEQIRQFDRKETARETVPTSDGTASNAV
The following text describes a protein:
Function:
Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KLRA9 to suppress NK-cell cytotoxicity. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Domain:
The Ig-like C2-type domains 3 and 4 are required for interaction with CD81; The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.
Sequence:
MGVPSPTPLSSLLLLLLILGTRCYARQVHVPRGPLYRVAGTAVSISCNVSDYEGPAQQDFEWFMYRPEAPATSLGIVSTKDSQFSYAVFGPRVASGDLQVQRLKGDSVVLKIARLQAQDSGFYECYTPSTDTQYLGNYSAKVELRVLPDELQVSAAPPGPRGRQAATSPSRLTVHEGQELALGCLAQTKTKKHTHLSVSFGRAIPEAPVGRATLQEVVGLRSDMAVEAGAPYAERLASGELRLSKEGTDRYRMVVGGAQAGDSGTYHCTAAEWIQDPDGSWVQVAEKRAVLAHVDVQTLSSQLAVTVGPGERRIGPGEPLELLCNVSGALPPPGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGIGSLGPGYEDRHIAMEKVASRTYRLRLEAARPADAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAASWWVERPEEGELSSGPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHGLGPEDEGIYHCAPSAWVQHADYSWYQAGSARSGPVTVYPYTHAVDTLFVPLLVGTGVALVTGASVLATITCCFMKRMRKR
The following text describes a protein:
Function:
Required for autophagy. Conjugation to ATG12 is essential for plant nutrient recycling.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAPHDEAAAWSEEAARRVWAGAVPLQVHLHDADVTALPPPPAFLTLGPRIGYLPLLIPVIKAHFSNALPPGVDTVWFEYKGLPLKWYVPIGALFDLLCADPERPWNLIVHFRGYPSEILSPCEGEDSVKWSYMNSLKEATFIITGNSKSVMNMSHADQVALWESVMKGNLDGYKSISTRLKIGPFEDDGLVRTASAERKRQQNSDEPESPGSSKPCRVPVRLYVRNVQEDLEYIEDAVPVSDWEGVSYINRPFEIRKVEGRSYITLEHALQTLLPEFFSSKAASRADGSHPAGALDSAADSSDATNSSRSSKEAEQALASPREVGAAKKTKVKLVRVQGIELDMDIPFLWVANNLKNPEYYLHICVYVGTRKQ
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYKIFASTTPQTEPVLNKLRAVLKTWQAVENGYEYVFVLGGDGFFVSTLANYNCDSCKVVGINTGHIGFYTSFNGDDLDENFISKLTSFEFKKINLLEVKTKNHSFLVLNELAVYTNTAYPINIFIDDNHWESYRGSGLLIGPRTGSTALAKSAKGAVIFPNVDVVQIIELNPLLHPNQITIQSPIILPMQTKVEFRIKKAFKAEQFPNFYADGIKLDLKNEDTSISFQLVLSRSMFHASLKTKDFIDKLKSTFIKQS
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
Subcellular Localization:
Nucleus.
Domain:
The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. AHA motifs are transcriptional activator elements.
Sequence:
MESSNLGGGGGGGGGGGPPPFLIKTYEMVEDAATNHVVSWGPGGASFVVWNPLDFSRDLLPKYFKHNNFSSFIRQLNTYGFRKIDPERWEFANEDFIRGHTHLLKNIHRRKPVHSHSLQNQINGPLAESERRELEEEINRLKYEKSILVADLQRQNQQQYVINWQMQAMEGRLVAMEQRQKNIVASLCEMLQRRGGAVSSSLLESDHFSKKRRVPKMDLFVDDCAAGEEQKVFQFQGIGTDAPAMPPVLPVTNGEAFDRVELSLVSLEKLFQRANDACTAAEEMYSHGHGGTEPSTAICPEEMNTAPMETGIDLQLPASLHPSSPNTGNAHLHLSTELTESPGFVQSPELPMAEIREDIHVTRYPTQADVNSEIASSTDTSQDGTSETEASHGPTNDVFWERFLTETPRSCLDESERQESPKDDVKAELGCNGFHHREKVDQITEQMGHLASAEQTLHT
The following text describes a protein:
Function:
Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction (By similarity); Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region consists of two globular folded domains that contain prolyl isomerase and chaperone activities; The C-terminal region binds nickel ions.
Sequence:
MQNHDLESIKQAALIEYEVREQGSSIVLDSNISKEPLEFIIGTNQIIAGLEKAVLKAQIGEWEEVVIAPEEAYGVYESSYLQEVPRDQFEGIELEKGMSVFGQTEDNQTIQAIIKDFSATHVMVDYNHPLAGKTLAFRFKVLGFREVSEEEILASHHGGGTGCCGGHGGHGGKKGGGCGCSCSHG
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MATRESLPLNSFKLNNDDRVSPFKVAVLVFVREYCTARLAQLGMSPHSHYNSIPPFSPQQCKDFCLLSLELIQCYDVTWEDFEIILEPGHYNLNATIVSEFIQSLQQIVKDGASGLLDLGESLEKLLMEPAKGKPMIRRDSVLGIFIRKMVLQLDRMTFEGTVELSNNLTTYLDKSKQSDDPLELVQVSRKQAELLVSQQLTMLQRNESLAHSPVNLQKIIDRILHENKDFAEANFLAHLNEMRCQDFGQAQKRLHQSYDQGTISVEGLIHSKLEENLMNNKTFRHASLNMAFLHASFGHHELAVTALRETVALSGEAADHVCLQESLAWFCHLEENPEMRLKMMERLVTKSSESNLHYLASLGLAMWTQDCALTGVDPTRIFEYLHTNDVANCQHSLTDMTLTCLALRAAIWNFYGYPRNALQVSQLLLTLHTGDPTKGNIYYNNEHMHMAICNIALHLSRQGRYADAESITKFAASQYACQQHSQMWKMTDLHVTFYRTLWLGQWDKAELIVSQLAVFDRAESQAKKAHLMLCKGDTSQGKFVLNALEEKLSNTKESSNHRMPNPGWKMGQKLRLQVQCLMLRAVLLSARQNFVEALLQISQASDICTKHHMSLELALVGMQSAEIQLLMNFTANALDLVRKHLNIIYTHGSLFEQGAATYLLARCLLAESGAKKCDPGELKSKKAEIFPLLTRAKKIFNQIEAFHHVKDVVFLEALLYNHLECSLRSMEYRMTKQLHEQQPSRND
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPFGDGGWGGDGGEALLGRDPLRSGSAPPTMEAGAEAAVAAERVFGSVGGGASFFSGIDGRGLGARMDEVTMRHGAAGVQEHFGNSASLSVRPHGQQFNGTGDLDEQQFGLSRVHSGGVMANYSASDMGPLWTDMNPDNVDYCRNIQNRSMSNIGKMNAYGNRDLSASYMFDSNLLDALSGLRLSNSLVMDQWNHGEGQLDEILECQRDFSKIGDENRSPLVGNVFRASRSDVHPLPIYGHGISQRQTSALDGSNVSRFSRHHIKGVDHLSLAAERVAAMQSGNLRRGTNLSRNAYMTNMVNPMSNRYYSNTDLDLVSSRRAFLDDLLAQQYLQEDNLSYDDSRIYHGEPRFSSSRMQRPGSHFYPNSRNILSHGDRQSRFFSLNRKAMGRNIGSQVYHDNALANYLDVPSLDNADRNGADSVELIDVVGHVKEVSMDQYGSRFIQQKLEIASPDDREKIFPEILSNVIVLTTDVFGNYVIQKFFEFATESQLIQLADQLKGRILELSLQMYGCRVVQKVLEVVGMDQKVDIVHELKNYILKCIGDQNGNHVIQKCIECVPEDRIPFVIDPILSQILVLCTHQYGCRVIQRVLEHCHDPVTQSAIMNEIMQQTFHLTDDKFGNYVVQHVLEHGKPEERSVIIQKLSGQVVTLSKQKFASNVIEKCLEFGTPEERDSLIGEIISSGQTFQELMKDQFGNYVVQKVLETCDDKYLEMILSSIKLHLNELKNYTYGKHIVARVEKLIVTGENRARMASMSGQHQQQQPNNCTAVDEH