lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MLQLRPVEEDESAAESLELNRAVADDDHFLLAELLSQERYRKCINQQSGWGIPGTPLRMAASKGHLRCLQLLLAHGADVDRLDVKAQTPLFTAVCGRYLSCVLALLRAGANPNGSHLNNSSPVLTAAREGDPEILRQLLQHGAEVNARSKVTLWASGVAVCSGPLYLSAIYGHLDCFKMLLLFGADPNYNSPEEKLNGRATQQKTVMELCLRHGCGVEYIQLLIDFGANVYLPTLIIEKSTKQNEAVELLLKERGCPKSLASQCRLTIRRHLIQVNKIQCLDSLEIPFRLINYLKHKPMNTALVH
The following text describes a protein:
Function:
Plays an essential role in chloroplast development and is required for chloroplast integrity and viability.
Miscellaneous:
MISCELLANEOUS: DJ1C lacks the catalytic cysteine residues in the endopeptidase domains which is a highly conserved feature of the family. However these residues are not essential for the function of DJ1C in chloroplast development.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MGSLGYSISMIASLSPTLMESRLISSMGCVSMTVAPSFSSVSVVSSSLGTTRRDRTLKLRSSMSPGMVTTLDSDVGVGSSATTKKVLVPIGYGTEEIEAVVLVDVLRRAGADVTVASVEQKLEVEGSSGTRLLADVLISKCADQVYDLVALPGGMPGAVRLRDCEILEKIMKRQAEDKRLYGAISMAPAITLLPWGLLTRKRTTGHPAFFGKLPTFWAVKTNIQISGELTTSRGPGTSFQFALSLAEQLFGETTAKSIEEFLLLRDGYQNPKNKEFNSIDWSLDHTPRVLIPVANGSEAVELVSIADVLRRAKVDVTVSSVERSLRITAFQGTKIITDKLIGEAAESSYDLIILPGGHTGSERLQKSKILKKLLREQHESGRIYGATNSSSTVLHKHGLLKEKRTTVYPSESDEPMNQQMIEGAEVVIDGNVITSLGLATVTKFSLAIVSKLFGHARARSVSEGLVHEYPRQ
The following text describes a protein:
Function:
Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
Subcellular Localization:
Secreted.
Sequence:
LALLFLVLSAGSGFTQGVRNHVTCRINRGFCVPIRCPGRTRQIGTCFGPRIKCCRSW
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSAIFNFQSLLVVILLFICTCTYIKSTYPSILEVRDKHSFSGLPRKAAIIGERLSPWVSASCLAMGLYLLFIKD
The following text describes a protein:
Function:
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Subcellular Localization:
Cytoplasm.
Sequence:
MREILEDICCSEVRVVVGEGSLSKLSKIKDNNAAVIYSRKISIADKINKYLPNAYFIPINDGESTKELSSVISLVEKLFEKNFDRGDYIIGVGGGTVTDVAGFLASIYLRGLNLINVPTTFLGMVDAAIGGKNGVNFNNIKNLIGTFYQPSMIISDLEFLETLPIEELKKGLAEVIKYGLTLDKELYDYLSLNKEKILNKDKQALEDIIFRSTLDKLSIVKEDERETKGIRIVLNFGHTIGHAIEAGSSFNVPHGYAISVGMVCEAKMAEELGYAEEGVVEDVLWLLQIYGLPYDISQIDAPVDLKLALNAINMDKKHRKDVILIPFPTRIGSWKKVEVPLDTVKGFAEQCLKK
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids; Able to melt short unstable dsDNA (15-mer with melting temperature, TM, 43 degrees Celsius) in the presence of a non-hydrolyzable ATP analog; a more stable dsDNA (20-mer, TM 55 degrees Celsius) is poor substrate. ADP does not support dsDNA melting. Addition of DnaA-AMP-PCP (an ATP analog, beta,gamma-methyleneadenosine 5'-triphosphate) to an oric-containing plasmid causes a DNA shift to more positively supercoiled topological species, stabilizing a positive wrap and right-handed filament as seen in the crystal structure without DNA. Filament formation generated by positive supercoiling may destabilize the origin unwinding element through compensatory negative supercoiling strain (Probable).
Subcellular Localization:
Cytoplasm.
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA (By similarity). An ATP-specific conformational change within the AAA+ domain accommodates and stabilizes subunit-subunit interactions necessary to support oligomer formation. ADP-binding does not allow oligomerization. Probably binds dsDNA via flexible domain IV (Probable).
Sequence:
MELNALIKKIESVDSYAREFLKKFEIKQEKGKFLFIAPGEDYREWLETIVNTFLEEEVRKLIEVKEKEEKKKVEIKDFLNPKYTLENFIVGEGNRLAYEVVKEALENLGSLYNPIFIYGSVGTGKTHLLQAAGNEAKKRGYRVIYSSADDFAQAMVEHLKKGTINEFRNMYKSVDLLLLDDVQFLSGKERTQIEFFHIFNTLYLLEKQIILASDRHPQKLDGVSDRLVSRFEGGILVEIELDNKTRFKIIKEKLKEFNLELRKEVIDYLLENTKNVREIEGKIKLIKLKGFEGLERKERKERDKLMQIVEFVANYYAVKVEDILSDKRNKRTSEARKIAMYLCRKVCSASLIEIARAFKRKDHTTVIHAIRSVEEEKKKDRKFKHLVGFLEKQAFDKIC
The following text describes a protein:
Function:
Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival; Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
Sequence:
MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASVIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAVNVGKTRGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQLYSERRTRVSERAVLWTDIILHMLKVNSITENFMAETPGRALEMSGLMEETRHVKEREKTKSLKRKDKKCFTCTECGRSLSNKENLKVHMRIHTGEKPFTCSQCGKSFRDASNLNKHMLIHTGEKTHTCGQCSKTFLRASELNDHLRVHTKEKLYSCALCGKSFANQTSLRYHQKTHTGVREYVCFECEKTFITAAILKQHQMIHTGEKPYKCAHCDMRFMYLGSQKTHERTHTGEKPYKCAHCDKRFSRIENQKSHERIHTGEKPYMCSHCNKRFRDAKCLKQHQRIHTGEKPYKCSHCDKRFSCIGNQKSHERMHTAEKLYKCSHCDKRFRHLGNQKSHERIHTREKPYRCSHCDMRFSQLRSLKIHENIHSGEKQVRFSQSETLKNTQECHV
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of alpha-D-glucose 1-phosphate (Glc1P) and, to a lesser extent, of other sugar phosphates.
Sequence:
MLYIFDLGNVIVDIDFNRVLGAWSDLTRIPLASLKKSFHMGEAFHQHERGEISDEAFAEALCHEMALPLSYEQFSHGWQAVFVALRPEVIAIMHKLREQGHRVVVLSNTNRLHTTFWPEEYPEIRDAADHIYLSQDLGMRKPEARIYQHVLQAEGFSPSDTVFFDDNADNIEGANQLGITSILVKDKTTIPDYFAKVLC
The following text describes a protein:
Function:
Binds specifically to the 3'-terminal U-tract of U6 snRNA; Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MADDVDQQQTTNTVEEPLDLIRLSLDERIYVKMRNDLELRGRLHAYDQHLNMILGDVEETVSTIEIDEETYEEIYKSTKRNIPMLFVWGDGVVLVAPPLRVG
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MSSSTRKITLKSSDDDQTHDRGRFCQNRNPLPNVTSKILTKVIEYCKKHVEATTSSKEKPSEDDVKAWDAEFIKVDLSLYELTCQNVVESIKDKTVEEVRQIFNIGEYDFTPEEEAAVRKELSWSSRSFE
The following text describes a protein:
Function:
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Miscellaneous:
MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPLFLILCLLQGSSFALPQKRPHPRWLWEGSLPSRTHLRAMGTLRPSSPLCWREESSFAAPNSLKGSRLVSGEPGGAVTIQCHYAPSSVNRHQRKYWCRLGPPRWICQTIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLCGIGSENNMLFLSMNLTISAGPASTLPTATPAAGELTMRSYGTASPVANRWTPGTTQTLGQGTAWDTVASTPGTSKTTASAEGRRTPGATRPAAPGTGSWAEGSVKAPAPIPESPPSKSRSMSNTTEGVWEGTRSSVTNRARASKDRREMTTTKADRPREDIEGVRIALDAAKKVLGTIGPPALVSETLAWEILPQATPVSKQQSQGSIGETTPAAGMWTLGTPAADVWILGTPAADVWTSMEAASGEGSAAGDLDAATGDRGPQATLSQTPAVGPWGPPGKESSVKRTFPEDESSSRTLAPVSTMLALFMLMALVLLQRKLWRRRTSQEAERVTLIQMTHFLEVNPQADQLPHVERKMLQDDSLPAGASLTAPERNPGP
The following text describes a protein:
Function:
Contributes to the transfer of mature mRNA from the nucleus to the cytosol. May function before mRNAs enter nuclear pore and in the same mRNA export pathway as MOS3.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MATNGEKVTATVVNGGGLSTGENPKKIVDLNTTELDRTDDILDGEVKGFSDSGEKKEETDSNGIGSTAGVDSGDISPVDDIQKKIRRAERFGVSVKLTEEEKRNSRAERFGTVAAAVVNGSEGTKKAEELKRKARADRFGVPSATSTTDKTEEEAKKKARLARFGKETKVDSAEENKRKARALRFSKEASADASSDLPEKQIIGKEAAVSGSAA
The following text describes a protein:
Function:
Involved in centrosome duplication and mitotic progression.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes on centrosomes in interphase cells and at spindles in mitosis.
Sequence:
MGRFKGENRSQARWIMGGVSKGRGSGKSRKPRQAAFGQTGARVCPSSPQQDAVPRFRWPGDAECASSTHTPTMSGCKLPMGLCPDMCPAAERARRERERRLHRLEVEPGGRGNAPRADPKRTVKEYSRPAAGKPRPPPSLLRPPPVLLATVRYLAGEVAGRGDVSCAEVASFVADRLRAVRLDLSLQGVDDADAATVLEAALATLLAVVARVRPEETRGAADPVLLQTQVQEGFGSLRRCYARGKGPYPRQAAFQGLFLLYNLGSVEALQEVLQLPAALRACPPLQAALAVDAAFREDNHARLFRLLRTLPYLQSCAVQEHIGYARRKALARLSRALSTPKGQTLPLDFIEHFLALDGLQEARDLCQAHGLTLDKDRVVFLRGQYSEEGLPPPGAYHILVGNKLQGHTLEDVVMAEEGDIHRPGSAA
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MSSILLAVIFLVNLVLSSVIPQTDLKLSVEEQSHLEGDPSVTHKVVFTIKHGDELLGDLTLALFGETCPITVENFYQLAIRGEDGQGYKNSKFHRIINNFVIQGGDYDGRGGKSIYGDSFNDENFILKHNKLGRLSMANAGPNTNGGQFFILNGKPTPHLDGHHVVFGQLVDGFDTLQKISTVETKDSSPLKPVVISDVKTAIDKSKVNQKEETGTSSSSETEGITAVSTSVYSYLFIILLLGVVFAAYKMMPRRDQITTIKD
The following text describes a protein:
Function:
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Subcellular Localization:
Nucleus.
Sequence:
MGMSDVYLRSRTAMERLASSDTFPVIARSSACRSLFGPVDHEELGRELRMRLAELNAEDQNRWDFNFQQDVPLRGPGRLQWMEVDSESVPAFYRETVQVGRCRLQLGPRPPPVAVAVIPRSGPPAGEGPDGLEEAPEQPPSAPASAVVAEPTPPATPAPASDLTSDPIPDVTPVATSDSTPDPIPDVATQDGEEQVPEQVSEQVSEQGEESGAEPGDELGAEPVSEQGKQQGAEPVEEKDEEPVEEQGAEPVEEKDEEPVEGQNGELVEEQDENQELKDQPLSGIPGRPAAGTAAANANGAIKKLSGPLISDFFAKRKRTAQENKASNDVPAGCPSPNVAPGVGAVEQTPRKRLR
The following text describes a protein:
Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). Involved in the mitochondrial import of CoQ precursors, plays a role in muscle mitochondrial function and fatty acid beta-oxidation.
Subcellular Localization:
Mitochondrion. Membrane; Single-pass membrane protein.
Sequence:
MVAPWRVSVRVCLSHLRCFELRQGLSLLRPSECPRDARLCWLLLGTLPKVVSLCGDVGEGAPDVLSRRRVRCSGAAGAGPAESLPRAGPLGGVFLHLRLWLRAGALLVKFFPLLLLYPLTYLAPSVSTLWLHLLLKATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYANTAFLETDSVQRLGRASCLPPFSHTGAVGGLRELFGYLGNGRKPPENLADQSFLERLLLPKADLVGSNAGVSRAQVPGHQPEATNLISVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVSSYQQAGIPVDLKRKIARLGINMLLKMIFVDNFVHADLHPGNILVQGANGLSSSQEAQLQQADICDTLVVAVPSSLCPLRLVLLDAGIVAELQAPDLRNFRAVFMAVVMGQGQRVAELILHHARASECRDVEGFKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTHKVKLESNFASIVFAIMVLEGLGRSLDPKLDILEAARPFLLTGPVCPP
The following text describes a protein:
Function:
Provides the (R)-glutamate required for cell wall biosynthesis.
Sequence:
MTNSPTILVFDSGLGGLTVLREVVATRPDAHYVYVADDAFFPYGHHSEDEIIARVVPLMGELIGTHDPDLVVIACNTASTLVLSHLRTAYSLPFVGTVPAIKPACAQSKSRRVSVLGTKGTVKREYTKALIRDFAQGCEVTLVGSPELASLAERALGGHPISDDDILAELTPCFVGDAADAGARTDTVVLACTHYPLLLDRLTRLAPWPVDWIDPAPAIARRVSDLLGPAIGGIMQSGAEMIFTSNRVHDLSATLTPFFGGRALA
The following text describes a protein:
Function:
Promotes the nuclear export of a subset of early and late viral mRNAs by interacting with mRNAs and cellular export proteins. Additionally may prevent the establishment of cellular antiviral state, by acting as an alternative splicing factor for cellular RNAs such as STAT1, resulting in a STAT1 mRNA incapable of producing the STAT1alpha isoform.
Subcellular Localization:
Host nucleus. Host cytoplasm. Note=shuttles between the nucleus and the cytoplasm.
Sequence:
MVPSQRLSRTSSISSNEDPAESHILELEAVSDTNTDCDMDPMEGSEEHSTDGEISSSEEEDEDPTPAHAVPAQPSSVVITPTSASFVIPRKKWDLQDKTVTLHRSPLCRDEDEKEETGNSSYTRGHKRRRGEVHGCTDESYGKRRHLPPGARAPRAPRAPRVPRAPRSPRAPRSNRATRGPRSESRGAGRSTRKQARQERSQRPLPNKPWFDMSLVKPVSKITFVTLPSPLASLTLEPIQDPFLQSMLAVAAHPEIGAWQKVQPRHELRRSYKTLREFFTKSTNKDTWLDARMQAIQNAGLCTLVAMLEETIFWLQEITYHGDLPLAPAEDILLACAMSLSKVILTKLKELAPCFLPNTRDYNFVKQLFYITCATARQNKVVETLSSSYVKQPLCLLAAYAAVAPAYINANCRRRHDEVEFLGHYIKNYNPGTLSSLLTEAVETHTRDCRSASCSRLVRAILSPATGSLGLFFVPGLNQ
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYYNKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNKKDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAIGRKHSKS
The following text describes a protein:
Function:
Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
Subcellular Localization:
Nucleus.
Sequence:
MRPAVLGSPDRAPPEDEGPVMVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEPPTPEPGPKTPPRTMQESPLGLQVKEESEVTEDSDFLESGPLAATQESVPTLLPEEAQRCGTVLDQIFPHSKTGPEGPSWREHPRALWHEEAGGIFSPGFALQLGSISAGPGSVSPHLHVPWDLGMAGLSGQIQSPSREGGFAHALLLPSDLRSEQDPTDEDPCRGVGPALITTRWRSPRGRSRGRPSTGGGVVRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGPFPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLTRHQRTHTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLTQHRRIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQHQRVHSAE
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
Purified ATP synthase is 25.9 nm long. The hydrophilic A1 domain is 9.4 X 11.5 nm, the central stalk is 8.0 X 3.9 nm and the membrane-bound A0 domain is 6.4 X 10.6 nm; the domains are connected by two stalks. ATP is synthesized or hydrolyzed by the A1 domain while ion translocation occurs via the A0 domain.
Sequence:
MKVGVVGDRETAIGFRLAGLTDVYEVKNDEEAVKAINELANNENIAFIIITERIAESIKDKLKNINKVIVEIPDKHGKLERIDPVKELIRKAIGVSMK
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MYMFSRLTVRMNSPYFTSAALDSSATETMGKSTINKDGIRRLRSRMAQGLRSEDDPPKVKAEVQEKSISDDPTHAHNPADCVKSTSYNTTSKMKEEPDQALLSPRKRGRGHLKVEYETEGVGLKREPYDWRTQLSFIREMRSKRDAPVDQMGAEKCYDTQGLPEVRRYQVLISLMLSSQTKDQVTAGAMQRLREHGLSVDGILKMDDETLGKLIYPVGFWRTKVKYIKQATALIQQEFGGDIPNTVEGLIRLPGVGPKMAHLAMDIAWNQVSGIGVDTHVHRISNRLGWTKKETKTPEETRRALEEWLPRDLWSEINWLLVGFGQQVCLPVGPLCSVCLNQHTCPSAHRSSPSKKIKSSPAKPNNKLASPTALVKEEPEDTSAQRVSHQRRKNTGPQLNQQDLSASRQETPSLARNRRKGRAGAPLSGQT
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKKQNFQSSPRLSVAEVKIAVAITLLAGSCKGAANDNAQAFNMMCGIRQILTAEADLPEQKDKEEVTRAIQQLIELNLSTAEDSMYDQKFEDDSSDGDKPQQYKENRPKWQKAKHLISAGNLEIDSIKILRLPNSPMRTTANKLINCSLEKAKALEKGLVEPTTQAEAQADFNDILFGDKAGEDKAGSKTYGTAATACGGNDPSNSEAGRSFMSDFLCLCSASGGSSPACTGTALSGITYSTASASATAAAALAKKCPLIPHTKTTAADIKAAAATFTAALKHKAGATTAGKIMLGKGDETQCNGAANGDCVLYKALDATGKLQIPWLSKFTAAISRLEAAHKNSLKNARIAAEVTNLKTAALRTYLQATVEVTQPPQPTKALSQQADKATQEPAKKVCNEAGGDQKACESLKDKDCTFNEKDKKCELKKEVKSKRENDCQEGKDGKTTNTNTTGSNSFVVNKAPLWLAFLLLA
The following text describes a protein:
Function:
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MIIPLINECGGNGKMLFVKLVTENDSTHLDDDYDQPDNMDEYINADEHIETDAVKELLDRLTGDSSSHRVLHRYTAQKHQHSEHGTQIVEGVMPKSEAQFYSVKLLCCWPSVDKKFPLLDVGSCYNPFSEFGEFHSVALDLQPATEKVYKCDFLKLEIVENQVASGLAASNSKTSNDTGGSKDSMMSSQENCQCLASNLITSKLNLPSDSSITHLPASSFQVVVFSLLLSYFPTPIQRWDCCLKAHQLLSVNGILIIITPDSSHQNRNAAMMKSWKLGIESLGFIRWKYVKQTHVHCMVFRKVSPCHTKDKTTKVLHAPEMLYTRQDYTGNDSDDSDSDGVKNNETRPEETDKELAKLFDELPAFD
The following text describes a protein:
Function:
Hydrolyzes alpha-, beta- and gamma-cyclodextrins with the highest activity with alpha-cyclodextrin (cyclomaltohexaose). Pullulan is the preferred substrate from linear substrates. Maltose is a major product of these reactions. Is also able to hydrolyze maltotriose and acarbose, and transglycosylate their hydrolytic products. Major reaction products of maltotriose and of acarbose are maltose and glucose, and glucose and pseudotrisaccharide, respectively. No activity with glucose or maltose as substrate.
Sequence:
MRKEAIHHRSTDNFAYAYDSETLHLRLQTKKNDVDHVELLFGDPYEWHDGAWQFQTMPMRKTGSDGLFDYWLAEVKPPYRRLRYGFVLRAGGEKLVYTEKGFYHEAPSDDTAYYFCFPFLHRVDLFQAPDWVKDTVWYQIFPERFANGNPAISPKGARPWGSEDPTPTSFFGGDLQGIIDHLDYLADLGITGIYLTPIFRAPSNHKYDTADYFEIDPHFGDKETLKTLVKRCHEKGIRVMLDAVFNHCGYEFGPFQDVLKNGAASRYKDWFHIREFPLQTEPRPNYDTFAFVPQMPKLNTAHPEVKRYLLDVATYWIREFDIDGWRLDVANEIDHQFWREFRQAVKALKPDVYILGEIWHDAMPWLRGDQFDAVMNYPLADAALRFFAKEDMSASEFADRLMHVLHSYPKQVNEAAFNLLGSHDTPRLLTVCGGDVRKVKLLFLFQLTFTGSPCIYYGDEIGMTGGNDPECRKCMVWDPEKQNKELYEHVKQLIALRKQYRALRRGDVAFLAADDEVNHLVYAKTDGNETVMIIINRSNEAAEIPMPIDARGKWLVNLLTGERFAAEAETLCVSLPPYGFVLYAVESW
The following text describes a protein:
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSESEVGKDTTPEPSPANGTGPGPEWGLCPGPPTVGTDTSGASGLGTPRRRTQHNKHKTVVVASAQRSPRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRSCTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSITDTPGDEDEEEGTMASCTLCLNKIMKTKVCRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASGDAGAAKDKGREKSSEGNPPQENKVLVPGGENEDTEGTKSEGAAPGMEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHVFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRIKTEGNLDQANQELRMVIKKIWKRIKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGADAPTSTSSVLQAGLRSLQDLGPEIRQALTYDTEEEEEEEEAAGQEAEEEEAENNPETYKDSIDSQPQAQWNSRISVSLPVKEKLPDSLSTGPSDDDGVAPNSRQPSGLQAGSQPHRRGSGVFMFTIPEEGSTQLKGVQGQDNQNEEQEVPDWTPNLDEQAGMPSNPVLLPPHWSQQHVNGHHVPRRRLLPPTPAGRKPSFTIQCLQRQGSCEDLPIPGTYHRGRTSGPGRAQGSWAAPPQKGRLLYAPLLLVEESTVGEGYLGKLGGPLRTFTCLQVPGAPSDPSHRKRGSADSLVEAVLISEGLGLFAQDPRFVALAKQEIADACHLTLDEMDSAASDLLAQRTTSLYSDEESILSRFDEEDLGDEMACVHAL
The following text describes a protein:
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDMSLVFFSHLNMCESKEKTFFKLMHGSGKEETNIEAKIRAKEKRNRLSLLLQRPDFHGETHTSRSALLAKETRVSSEEALKWAESFDKLLSHRDGVDAFTRFLKTEFSEENIEFWVACEDFKKCTEPQQLILKAKSIYEKFIKNDAPKEVNLDFHTKEVITKSIAQPTLHSFDAAQSRVCQLMEHDSYKRFLKSEIYLHLIEGRPQRPTNLRRRSRSFTYNEFQDVKSDVAIWL
The following text describes a protein:
Function:
May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.
Subcellular Localization:
Secreted.
Sequence:
MESLTGNIILIFSLLVQAFGLPPKEVCLLPVAEGPCRATIPRYYYNRYTQKCEDFSYGGCQGNDNNFETLEECEKTCWKIPKIPKICRLDKEEGPCRGLFKKYYFNFTAMQCEEFDYGGCRGNANQFDDKRSCMESCDPHRSIPAFCLSPEHKGFCSASIPRYYYSPIRKSCVEFIYTGCGGNSNNFVSKQVCNAVCTKGRKMRPRPANVLIRRKVKRINE