lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the stereoinversion of LL-2,6-diaminopimelate (L,L-DAP) to meso-diaminopimelate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Subcellular Localization:
Cytoplasm.
Sequence:
MATIHFTKVHGSQNDFFLVDEEGNQIMDWSDAKRADFAIKLCDREHSLGGADGILYVTKSSEAGPIGQMRVVNSDGSIASMCGNGLRTVARYLLEKHALTEAKVETMKAILDVKKATSLGFDIPTYQVEISPVKFNAESLPMNVGVEKLFNQVVPELDAELAFSAVSVPNPHLITFVDQTVLDSDRQETLASYLNSENPYFPDGVNVSFVKRLSDDAIYVRTFERGVGFTNACGTAMSACSLIKKMLDKDTFETPLNVYNDGGRVQVTAKKDEAGDISLQLIGNATFVSTGSVSYESDTVTELTNEATPEQAQYQELVKEVKEFLKTTE
The following text describes a protein:
Function:
May be a monocopper oxidase of unknown specificity. Involved in directional growth processes, possibly by participating in cell wall expansion.
Subcellular Localization:
Secreted, cell wall. Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Partially soluble and located in the cell wall.
Sequence:
MDLFKILLLVFFVNISFCFAADPYSFYNFEVSYITASPLGVPQQVIAINGKFPGPTINVTTNENLVVNVRNKLDEGLLLHWNGIQQRRVSWQDGVLGTNCPIPPKWNWTYEFQVKDQIGSFFYFPSLHFQRASGGFGSFVVNPRAIIPVPFSTPDGDITVTIGDWYIRNHTALRKALDDGKDLGMPDGVLINGKGPYRYNDTLVADGIDFETITVHPGKTYRLRVSNVGISTSLNFRIQGHNLVLAESEGSYTVQQNYTSLDIHVGQSYSFLVTMDQNASSDYYIVASARVVNETIWRRVTGVGILKYTNSKGKAKGQLPPGPQDEFDKTFSMNQARSIRWNVSASGARPNPQGSFKYGSINVTDVYVLRNMPPVTISGKRRTTLNGISFKNPSTPIRLADKLKVKDVYKLDFPKRPLTGPAKVATSIINGTYRGFMEVVLQNNDTKMQSYHMSGYAFFVVGMDYGEWTENSRGTYNKWDGIARSTIQVYPGAWSAILISLDNPGAWNLRTENLDSWYLGQETYVRVVNPDENNKTEFGHPDNVLYCGALSKLQKPQKVSSSASKSIGFTSLSMVVMALVMMMMLQH
The following text describes a protein:
Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAPTIQTQAQREDGHRSSSHRTVPERSGVVCRVKYCNTLPDIPFDPKFITYPFDQNRFVQYKATSLEKQHKHDLLTEPDLGVTIDLINPDTYRIDPNVTLDIADEKLLEEEIQAPSSSKRSQQHAKVVPWMRKTEYISTEFNRYGVSNEKPEVKIGVSVKQQFTEEDIYKDRDSQISAIEKTFEDAQKPISQHYSKPRVTPVEVMPVFPDFKMWINPCAQVIFDSDPAPKDASGSAALDMMSQAMIRGMMDEEGNQFVAYFLPGEETMRKRKRDQEEGLDYMPEDIYDYKIAREYNWNVKNKASKGYEENYFFIFREGDGVYYNELETRVRLSKRRVKAGVQSGTNAVLVVKHRDMHEKELEAQEARRAQLENHEPEEEEEIEVDQETQGSDAEDGEKGSGSEKEGSGAEQSGSESEREEAEEEEKEDEEEKESSEEDRAARDKEEIFGSDDDDSDEDGPNESGQDGEDSGSDDEEEKGQGRRSRSASSSPFGSDHSQQENEDQSASDQGSGSSTGSDSD
The following text describes a protein:
Function:
Alpha-ketoglutarate-dependent xanthine dioxygenase is a non-heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid. Allows xanthine utilization as a nitrogen source.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSATATTTVVEPPTTTLTGATEPPFTAYTTSQGLRVSPVPLPEHNTDVGFGALIENVDLNNLSDEQFEDIRKALFEHQVVCFPNQHNLPPETQYAITHRFDPESSTYGHGNRTNQQNNSILHPDLHTLPGVPQVQLIGHGVVKDHYGLEEVRLKHPHHRTFHRDPISEEEEKEKQVTRFYRWHIDAALYDYNPPVVTTLLAVNAPQGTQTLRYDDKSGHEMPVPLGSTAFASGYRMYELLTDEEKKVAARTRVQYFPHAYVTINKARALPNGLGMYSEGLELDKSELPPWEESRVKTFPLLWKNPVTGKLALQTHGCCAEKILIDNEDGTTTVIDDLPKVREILYNYQRPGINPERVYCHDWKNGDFVIFHNRGVTHCITGAYRDDQTRIFHQCNLAASHPPAGPSEEDIAAM
The following text describes a protein:
Function:
Probably involved in the biogenesis of the COX complex.
Subcellular Localization:
Membrane. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MALPAVRMLLGGSGVRKLLLLSSVKAQLLNTPVTLAYSATPCRCMKSGHTYLPKSLRFFATRSSSSVSSAAESSEDTILKWILLLIPVATFSLGTWQVKRRSWKLNLIQEMETRVSGKPIPLPTDSMELRELEYCPVKVKGHFDHSKELYILPRTLVDPEREARQAGQLASNTQSGAQVITPFYCTDLGITILVNRGFVPKNKVNPETRPKGQVSGEVELVGIVRLTEARKPFVPHNDPTRNLWHYKDLAAMAQVVGAEPILIDADRGSTVPGGPIGGQTRVTLRNEHMQYIVTWYGLCAATTYLWCKKFLMKVAL
The following text describes a protein:
Function:
All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt the polarization-sensitive 'dorsal rim area' (DRA) of the eye fate instead of the color-sensitive default state. This occurs by increasing rhabdomere size and uncoupling R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision.
Miscellaneous:
MISCELLANEOUS: [Isoform E]: Protein lacks the homeodomain but is still capable of interacting with exd; MISCELLANEOUS: [Isoform F]: Protein lacks the homeodomain but is still capable of interacting with exd.
Subcellular Localization:
Nucleus.
Sequence:
MAQPRYDDGLHGYGMDSGAAAAAMYDPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVYTPHPGPSGYGHDAMGYMMDSQAHMMHRPPGDPGFHQGYPHYPPAEYYGQHL
The following text describes a protein:
Function:
Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MGEDVIDSLQLNELLNAGEYKIGELTFQSIRSSQELQKKNTIVNLFGIVKDFTPSRQSLHGTKDWVTTVYLWDPTCDTSSIGLQIHLFSKQGNDLPVIKQVGQPLLLHQITLRSYRDRTQGLSKDQFRYALWPDFSSNSKDTLCPQPMPRLMKTGDKEEQFALLLNKIWDEQTNKHKNGELLSTSSARQNQTGLSYPSVSFSLLSQITPHQRCSFYAQVIKTWYSDKNFTLYVTDYTENELFFPMSPYTSSSRWRGPFGRFSIRCILWDEHDFYCRNYIKEGDYVVMKNVRTKIDHLGYLECILHGDSAKRYNMSIEKVDSEEPELNEIKSRKRLYVQNCQNGIEAVIEKLSQSQQSENPFIAHELKQTSVNEITAHVINEPASLKLTTISTILHAPLQNLLKPRKHRLRVQVVDFWPKSLTQFAVLSQPPSSYVWMFALLVRDVSNVTLPVIFFDSDAAELINSSKIQPCNLADHPQMTLQLKERLFLIWGNLEERIQHHISKGESPTLAAEDVETPWFDIYVKEYIPVIGNTKDHQSLTFLQKRWRGFGTKIV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MAMATSSSYPPPPPFYRLYKNFEQDPSSAPEPPPPIDGPFKALGVDYTGDVVIPSLESHNVRQLYPKGPNIDFKKELRTLNRELQLHILELADILVERPSQYARRVEDITLIFKNLHHLLNSLRPHQARATLIHMLESQIQRRKEAIEDIKQRRVEAQKLLAESLHILDASQAN
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (By similarity). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (By similarity). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (By similarity). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Essential for postnatal survival (By similarity); Also has a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGNLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDMLSGLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
The following text describes a protein:
Function:
This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy; Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPGFNYGGKGDGTGWSSERGSGPEPGGGSHGNSGGHDRGDSSNVGNESVTVMKPGDSYNTPWGKVIINAAGQPTMNGTVMTADNSSMVPYGRGFTRVLNSLVNNPVSPAGQNGGKSPVQTAVENYLMVQSGNLPPGYWLSNGKVMTEVREERTSGGGGKNGNERTWTVKVPREVPQLTASYNEGMRIRQEAADRARAEANARALAEEEARAIASGKSKAEFDAGKRVEAAQAAINTAQLNVNNLSGAVSAANQVITQKQAEMTPLKNELAAANQRVQETLKFINDPIRSRIHFNMRSGLIRAQHNVDTKQNEINAAVANRDALNSQLSQANNILQNARNEKSAADAALSAATAQRLQAEAALRAAAEAAEKARQRQAEEAERQRQAMEVAEKAKDERELLEKTSELIAGMGDKIGEHLGDKYKAIAKDIADNIKNFQGKTIRSFDDAMASLNKITANPAMKINKADRDALVNAWKHVDAQDMANKLGNLSKAFKVADVVMKVEKVREKSIEGYETGNWGPLMLEVESWVLSGIASSVALGIFSATLGAYALSLGVPAIAVGIAGILLAAVVGALIDDKFADALNNEIIRPAH
The following text describes a protein:
Function:
Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDTYDELSLEASKFIQDLTLYEASKDGLFRVDKGLSNNPEFEETKRIFAAKMAKIHLQNQQKSIPDTGISEGNGLTHQYNYSLPKSVEEGPVIYNGLSNSSVGPSDYKTYRESYKGKPDIDSADRSEESVFKHDSEIMLPSPLGKVGNTIPTQQFTSKKAISPSIESLERERTIKNNITGFENYRLCNSSSMKNCKPHQNSRHGEVEDTMAENFTENKTPFKQCSALISSSVTFGDDTHTNIPQKKLFNLPSTSSINTQNNSDDVYLSKTNAAKEFHGEQRGLCSTNSLGFGNPNDVISASYCVGYNDNFPGEIKQKQSPHYTFHSGHSSVDEQPQAIPFCCKDSSGQGPASTIDSDHTDILQDSSALMKIKLPCQTLSQSSKQGSSKAEKKLEAITRHVEQEMDAHNKADYFGTCVKCSKGVYGASQACQAMGNLYHNGCFICSACSRKLRGKAFYFVNGKVYCEEDFLYSGFHQSADRCFVCGHWIMDMILQALGKSFHPGCFRCVVCNECLDGVPFTVDMENKIYCVKDYHKILAPKCAVCSLPILPSEGTDETIRVVSMDKDYHIDCYRCECCALELNNEDDHRCYPLDGHLFCHNCHLKYLENHNLS
The following text describes a protein:
Function:
Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity).
Sequence:
MLTKDLSVTFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGIVFKTIGFFIANEVSPRFDHLTKEDTGFIGFKNMEQIAEHPLEENLAAIRRLKQDYPDKVLIASIMGENEQQWQELARLVEEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSSLPMLAKMTPNIGDMCEVALAAKRGGADGIATINTVKSITNIDLNRKIGMPVVNGKSSISGYSGKAVKPIALRFIQQLRMHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFASLQEMIGLANGNIIPAEDLDRSYIVYPRINQEKCVGCGRCYISCYDGGHQAMEWDEHSRTPHCNTEKCVGCLLCGHVCPVACIDLGEVKFKKGEKEHALTL
The following text describes a protein:
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).
Sequence:
MSRRNCWICKMCRDESKRPPSNLTLEEVLQWAQSFENLMATKYGPVVYAAYLKMEHSDENIQFWMACETYKKIASRWSRISRAKKLYKIYIQPQSPREINIDSSTRETIIRNIQEPTETCFEEAQKIVYMHMERDSYPRFLKSEMYQKLLKTMQSNNSF
The following text describes a protein:
Function:
Phosphatase involved in the dephosphorylation of myo-inositol monophosphate to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
Subcellular Localization:
Cytoplasm.
Sequence:
MADPWQECMDYAVILARQAGEMIREALKNEMDVMIKSSPADLVTVTDQKVEKMLMSSIKEKYPCHSFIGEESVAAGEKTVFTESPTWFIDPIDGTTNFVHRFPFVAVSIGFLVNKEMEFGIVYSCVEDKMYTGRKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRKPETLRIVLSNMEKLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDMAGAGIIVTEAGGVLMDVTGGPFDLMSRRIIAANSITLAKRIAKEIEIIPLQRDDES
The following text describes a protein:
Function:
May be involved in the regulation of photosystem II.
Subcellular Localization:
Plastid, chloroplast thylakoid.
Sequence:
MASTSCCLLHQSTARLGASPRLAAAPPRSAQLLVCKARKQEAAADQSDVSRRAALALLAGVTAAAGAKVGPAAAAYGEAANVFGKPKASTEYIAYSGDGFKLLIPSKWNPSKEREFPGQVLRYEDNFDANSNVSVIIQPTSKKTIADYGSPEEFLSQVDYLLGRQAYGGKTDSEVRNITLWTVVTTAMHVCISVAAVLLALHESTCVQGGFETGAVATANVLESSTPVIDGKQYYAVSVLTRTADGDEGGKHQLIAATVSDGKLYICKAQAGDKRWFKGARKGVEKAASSFSVA
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MDQHTLDVEDTADARHPAGTSCPSDAALLRDTGLLADAALLSDTVRPTNAALPTDAAYPAVNVRDREAAWPPALNFCSRHPKLYGLVALVLLLLIAACVPIFTRTEPRPALTITTSPNLGTRENNADQVTPVSHIGCPNTTQQGSPVFAKLLAKNQASLCNTTLNWHSQDGAGSSYLSQGLRYEEDKKELVVDSPGLYYVFLELKLSPTFTNTGHKVQGWVSLVLQAKPQVDDFDNLALTVELFPCSMENKLVDRSWSQLLLLKAGHRLSVGLRAYLHGAQDAYRDWELSYPNTTSFGLFLVKPDNPWE
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MELPSAPHSFHSLAGVQVSRWDAESLRRLPALERGPLKSILDALGRSSAIAQGLRAIITTYEKMLGADHRVYIATAGYGNRVQVKGFLKVGSKTLFVTSEGSPQLREIRPLSVLDFYVHETCQRTGVGRLLFDRMLLEESAHPAKLAYDRPSPKLLAFLRKHFGLSKYIPQTNNFVVFNQYFENGERGGKVNQTDKGAYGSGEGSLESRNGLDSAPSRTRSGALFSKRTPANQEASTAAIENESMRLSGRRNSEGVRIFGIMDENARGGSDRQAAGDAPPSASPMAIDSGSCGHDQQRPPLPMHGRRSRRGTSETDIFSGQCDASSGFEEPVPHGPTFGRRASNQGNAPKNPFFTTAPSAVGLPPLEAHSNWTRAEANNQENSGKQGSATLKRSEEARSVGAVAWTVRTLQMSGKGAAEVLGADSGLLGEAYKDAYRQALPRSRQRVQ
The following text describes a protein:
Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Nucleus, nucleolus. Note=Has been shown in human and mouse to be a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
Sequence:
MCALPSPRAQRPPACTRTSKNSCALLASRYNGSCSNDFGRLLASNLKILRNIILKDDTEFVKVWSKTSKSLISYESGRIYFDNYRCCYSSLLPEPELLYELPRTPKTEKIEDALLCQCPLENVLPNASEQKSCLLTLTANNWLYLLSADTGETLQRVYLSSRFKFSRSLGWDSSQETFYVKSVQCKQTALERQAGVDNNILMRVAAFQVFPLQLVGMLEINKKVFGKTAVDVLLSQGVLAVSHSSKLVRLYSFEYIVNKFRTEELILGQQCELNNARGIVGDAPYGVPVNICIHECPPVLFEMTYFENGVQIGGHPWHYIYTPNHKRHRGTHHVCSITDGALAKNGVQDMKCDSLEVDWIFFHPDDSGRIIHAGPSTINILKIMAETGCDWKYEIITDFSITAARDSNASQVIVTSSGRTVKRRFQMLDDDPAQETFRMVKYEDELDLLAVVDITHAEDEGQARLRLHDNKTGALMKRVPLEEPWDVTYSHEVYFDRDTIIHTVQEKNNSFCCHVYKMKRPASDQP
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MHIHKLKKKIKKKKEGKYLTKKHILRKLFLNEEEFRKLCIFKGIYPKDFKEIPLKYRKKFYKHKVFYTRNDFLKLSHEKIINDFRKIKIYLKKYKKCKLTLEDFTRSKNIVANFPVYKLEHIIKERYPILSYAVDHLDDALSCIIAYSQLPSNHKYGIKNNMVKTCEMLKDHFHYYVYKTNRIKKAFISVKGYYLQAEILKKKVTWIIPHIFTPYLDTSIDFKLISDFIEYYIALLKFVLFKLYKLDNMLYPPKQDNDLKNEKLAHLSYDKDYSTNENNIDINMNQELQSKCNVNTNEDLNTCQEKTKEKNHKSDNNPHEHTTNIDNNNFNNIHLQDNCDLNKNEGKNLTNNIIHKNSEADNGHVHPDDHIDIDEHNKLKELFKNHIFYIHNDMPFDVLSIIILSCGGKISWNSRISPIHYDDNNITHEIYEKDKNTIHLNNPENEYKRIHIQPQYIFDCLNEKNILPCSDYLTEKENLPVHLSPFIEDENFKNLVKKEEYTINKMLNQKIKEEQYKDFSKENNNIFKSPNYKEEEEEENDDRETANLILNNKRQAALNNQLERENEDINQLKENDTILNKQTDQTQILKTQNLKSQEQEIQRHKIVLSKKKRKLFARIDMAQKRQKATIDKFMKKINKNKSK
The following text describes a protein:
Function:
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Sequence:
MSSLAAASCESLSPSAESQEKKPLKPCCACPETKKARDACIIENGEEKCQHLIEAHKECMRSLGFKV
The following text describes a protein:
Function:
Involved in cell morphogenesis. Binds to F-actin and stabilizes the actin filaments.
Miscellaneous:
MISCELLANEOUS: Present with 11100 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence:
MEKIKEKLNSLKLESESWQEKYEELREQLKELEQSNTEKENEIKSLSAKNEQLDSEVEKLESQLSDTKQLAEDSNNLRSNNENYTKKNQDLEQQLEDSEAKLKEAMDKLKEADLNSEQMGRRIVALEEERDEWEKKCEEFQSKYEEAQKELDEIANSLENL
The following text describes a protein:
Function:
High affinity receptor for INSL5. Also acts as a receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAVLWVLSNCARRAPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTATVLNVYASIFLITALSVARYWVVAMAAGPGTHLSLFWARIATLAVWVAAALVTVPTAVFGVEGEVCGVRLCLLRFPSRYWLGAYQLQRVVLAFMVPLGVITTSYLLLLAFLQRRQWRRQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWNSTFYTIQTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQALADTFRDLRSRLWPQGGGWVQQVALKQVGRRWVASNPRESRPSTLLTNLDRGTPG
The following text describes a protein:
Function:
Responsible for microtubule translocation. May be important for the organization of phragmoplast-specific arrays of microtubules. Plays an essential role in stabilizing the mitotic spindle. Required during mitotic cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MSLTPDLSRKVGVGMAPSPSPFFTPRPERRRATEPRGIDYNSNRLDKDKEVNVQVLVRCRPLNDDEQRINVPKAITCNESKREVSVVQNVANKQVDKVFTFDKVFGPKAQQRSIYDQAISPIVKEVLDGFNCTVFAYGQTGTGKTYTMEGGMRNKAGELPAEAGIIPRAVRQIFDTLEGQNADYSMKVTFWELYNEEITDLLASEEPSKSSEERQKKPVSLMEDGKGCVVVRGLEEEAVYSANDIYNLLERGAARRRTADTLLNKRSSRSHSVFSITIHVKEMTVGDEELIKCGKLNLVDLAGSENISRSGAREARAREAGEINKSLLTLGRVITALVEHSIHIPYRDSKLTRLLRDSLGGKTKTCIIATISPSAHCLEETLSTLDYAHRAKNIKNKPEANQRMSKAVLLKDLYLEFERMKQDIRAAREKNGVYIPHERFLQDEAEKKAKNEKIEQLEIDLNISEKQIDKFRELYLREQEEKLNLKAELKECQANLENSKKALHELQENHRIAISTLKEKEFIISKQIHSENCLIDCAKDLRKNLQNASEDITSLFSRIDHKDKLEADNQNLLHTFGSRLEKSLNDLHKIIHGLNSQQQHQLRGMEEHVSSFLASKCDVTKVMESKINKMTQTHTSGMASLKELVDVLQLEASTDLDQIKSKISSQATAVEKFLRAASLEAKDFVCDIKNSLDEQREILDFSAKQQEEGLRRSLVSAQLISQATVNFFDDLHQRASEVMKLLDKSNIDKVDQLQKFEKTFKEEALREENLALEKIGAILATMTTKKAAMVSEASRNFQDSSAKENKQLLRELTGVQQVSASAKQKLNGYVNEVTQNFSEDTLTYTGSRMTLETCLQECTNKVDNLDEQLGKTQSGIHQILINNLAELEHISQESSIRIGGAYDEFLSTSSSVDQKVEAHGHDLLTSFNDSLTLDMEHKNRIESISSMCLNQLNSMQQNHGECISDIQCTKEQCLQKDYMVDMYTDKTPMKRLVQIPSLASIEDMRTVISKVSLENEPKWSGAEGKNQRQLQQCTGASPNRTPFADVN
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
METAKRSAEQLARDAQRKRRKQAKTDAKNGAQWDRCMFKVVRKNRFCNISRVPGSLFCGNHLPDSDAAVSSKSQKFKAATRRRVPCPVDASHTVYEFDLAKHVLVCNRVKDADAMKKLAYYSHNINSGSHSSVKEEGSTASSEEPAGDKENEHSEPSAQEQQGIIDKLVAIDFADLRKRIEAAYDSCVGELLLEKLQHKCCDQLFEEKKKAGASKSVLRHIEQQASIIGHMEQAKLLQDSNAAFVELGAGRGMLSLALAQMFPDSLYVLIDRAHTRGKADRFIGGDNKGDEGAKDTTLRAKIDIRHLNFAGMQEILDKPVVCMSKHLCGVATDLSLRAVAQTLPESSGGKETSSEITVSSSFQGLAIALCCHHVCAWEDYVNPSFFEAQGFKPQEFELLTSMTSWTTCGMGLEGDAVQHILGIRHVKCFY
The following text describes a protein:
Function:
Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence.
Subcellular Localization:
Nucleus.
Sequence:
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGGGAGGGGGSSQAGGAPGPPSGGPGAVGGTSGKPALEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGPGFAGGGGADDMGAGHHHGAHHAAHHHHAAHHHHHHHHHHGGAGHGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGSAGGAGFPREPSPPQAGPGGAKGTADFFL
The following text describes a protein:
Function:
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNKTTEYIDAMPIAASEKAALPKTDIRAVHQALDAEHRTWAREDDSPQGSVKARLEQAWPDSLADGQLIKDDEGRDQLKAMPEAKRSSMFPDPWRTNPVGRFWDRLRGRDVTPRYLARLTKEEQESEQKWRTVGTIRRYILLILTLAQTVVATWYMKTILPYQGWALINPMDMVGQDLWVSFMQLLPYMLQTGILILFAVLFCWVSAGFWTALMGFLQLLIGRDKYSISASTVGDEPLNPEHRTALIMPICNEDVNRVFAGLRATWESVKATGNAKHFDVYILSDSYNPDICVAEQKAWMELIAEVGGEGQIFYRRRRRRVKRKSGNIDDFCRRWGSQYSYMVVLDADSVMTGDCLCGLVRLMEANPNAGIIQSSPKASGMDTLYARCQQFATRVYGPLFTAGLHFWQLGESHYWGHNAIIRVKPFIEHCALAPLPGEGSFAGSILSHDFVEAALMRRAGWGVWIAYDLPGSYEELPPNLLDELKRDRRWCHGNLMNFRLFLVKGMHPVHRAVFLTGVMSYLSAPLWFMFLALSTALQVVHALTEPQYFLQPRQLFPVWPQWRPELAIALFASTMVLLFLPKLLSILLIWCKGTKEYGGFWRVTLSLLLEVLFSVLLAPVRMLFHTVFVVSAFLGWEVVWNSPQRDDDSTSWGEAFKRHGSQLLLGLVWAVGMAWLDLRFLFWLAPIVFSLILSPFVSVISSRATVGLRTKRWKLFLIPEEYSPPQVLVDTDRFLEMNRQRSLDDGFMHAVFNPSFNALATAMATARHRASKVLEIARDRHVEQALNETPEKLNRDRRLVLLSDPVTMARLHFRVWNSPERYSSWVSYYEGIKLNPLALRKPDAASQ
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
Sequence:
MTMQQPIPVPPPDETPAPQAEAAARVTPMMEQYLEIKAAHQGLLLFYRMGDFYELFFEDAEIASKTLGIVLTKRGKHQGADIPMCGVPVERAEDYLHRLISAGHRVAVCEQTEDPAAAKARGNKSVVRRGVVRLVTPGTLTEDTLLDARANNYLLAIARARSSTGGDRFGLAWIDISTAEFMVTECSGGELAATLARINPNEAIVTDALYNDNELGQTLRELPAVTPLTRDVFDGATAEKRLCDYFAVATMDGLAQLTRLEATAASAAVTYVDRTQVGRHPPLSPPAREASGATMAIDPATRANLELTRTLAGERRGSLLDAIDCTVTSAGSRLLAQRLAAPLTDAPAIARRLDAVGAFVADSAAREDIRSILRGAPDMSRALARLSVGRGGPRDLAGLRDGIIAADQVLARLGELDQPPQEIAAVMAALTRPSRELAAEFATALDEQLPLIKRDGGFVRQGYEPALDEARNLRDASRLVVASMQARYADDTGVKGLKIRHNNVLGYFVEVTAQHGDKLMSAPLNATFIHRQTLAGQIRFTTSELGEIEAKIANAGDRALGLELEIFERLCAKALEISDDLRAAAQGFALLDVATSLAKLAVDENYVRPEVDSSLGFAIEAGRHPVVEQALKRNGEPFIANACDLSPAPAQKSGQLWLLTGPNMAGKSTFLRQNALIALLAQIGSFVPATRARIGIIDRLFSRVGAADDLARGRSTFMVEMVETAAILNQAGERALVILDEIGRGTATFDGLSIAWAAIEHLHESNRCRTLFATHYHELTALSAKLPRMFNATVRVKEWQGNVVFLHEVLPGSADRSYGIQVAKLAGLPPAVITRAKSVLAKLEAQDRGQTARALADDLPLFAVPSRAAAEAAPPSEAELLMDAVKALHPDEMSPREALDALYALKAKLPKQ