lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.
Subcellular Localization:
Nucleus.
Sequence:
MKNHLSNVLCAMRSDFKDNHQETINKMIQFGTVKYGIVKQLKDRARSADKDIGSDQEENGGCSPLTTATTTASPSRSPEPEEEQPEEQSTSEQSIPEQSTPDHQLENDIKSEAKSEIEPVEDNNNRVAMTKPSSEEREPNASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSSAVPSTEVTLPGGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQKAEARMAEAKARQHLINAGVPLRESSGSPAESLKRRREHDHESQPNRRPSLDNTHKADTAQDALAKLKEMENTPLPFGSDLASSIITNHDDLPEPNSLDLLQKRAQEVLDSASQGILANSMADDFAFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKNKKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETFRNRAVKYMSEWNEDRE
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase involved in the regulation of cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 and 'Lys-79' of histone H3 (H4K20me3 and H3K79me3, respectively) during diapause formation, a state of obligate dormancy.
Subcellular Localization:
Nucleus.
Sequence:
MVDRIDPLDITNIKDLSTWMKTKNWRNIAKLEPCRFKESGRGMRTRKGLKAGQLLVQIPRLLLMTAGDFRTSKEWSWIVDKNLSCHDALVLYLLVEKNKRDSSFFHAYIKTLPEVFSMPTDLRSEMTHMLPNFIAMKLQDKIKSLQDSFKNVARGYKSICIKELGFSDFKWAYYVVNTRAVHITGSSGKFNADSSDCMALAPFLDLLNHTHDTSSISGFNPYTNCYEIETLSKTPKCSEVFINYGPHDNLSLFVEYGFMIPRNPNNFVPFEMTDFISACNEYNVKLSNLCLQTINLHNLMKNLGCFADGPSWSVKVLLKVLSCDWSSLMRIEDIIYRDFENHGLTEKTLLNCILEKKKEELQNSLSTIAKDKNCQIANCIVSFLEECLSIIEFSYAN
The following text describes a protein:
Function:
Transcription factor which represses a set of lipase genes involved in fat catabolism.
Subcellular Localization:
Nucleus.
Sequence:
MDIIQKSIFNSGPHSRGIYEPPLGYFTPYNTPPYIAAYSDSGSWLADHHQHHQQQHQQHQQQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKARGQQDELCRSPVEFPDDSKSCSSSSECGTASDFVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHLCEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKHSIHLIASQPLTLPSVPCLLEASSESAFTCLPAASSVESTSSSSSARYYDDSNNEPSDYSLKPKQDAEFSPSYWLGDRQHSYLHSEDFFVKMDVESPLDLRIHRI
The following text describes a protein:
Function:
Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage.
Subcellular Localization:
Nucleus.
Sequence:
MNLHGLELPGRDQRLSPEVIDLTEDIEDDGADVSEVTLLDLTRIPEFQPRRRIRTSRNHLDANLSNVPTINSIPSPVTRPPVAVGGGIFYGARRTRNRSQTQRRTLLENGFRNSRKKAQDSSNSIAERVSPPPGFCYDVHPHNNIACAKCGNELVSDEKKSIFAAKCGHLFCSTCAKELRKKTVPCPVQHCRKRITKKFIFPLYL
The following text describes a protein:
Function:
Plays a role in embryo pre-implantation development.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSRLIIKNLPNGMKEEHFRTMFAAFGTLTDCGLKFTKEGKFRKFGFVGFKSEEDAERALKHFHKSFVDTSRITVEQCKSFGDPTKARAWSKHSRGSAARNSEQLEEKKAAADQGLKKLEGDEGFQEFLAVHQNRAQAPTWANDTAADPAAAKPHRKDRKKKAASDDYLNFDSESESEEPEQDEEEEEEDKDQGEKTEHLTGPGKEALKTGLSDMDYLRSKVVRQQGESEEEEDDDEELVTEKEPVPAQPLDSAYESGDKDTAHKSKAKLAKAPRTQEQTEPTTEFTVKLRGAPFNVTEQQVREFLVPLKPVAIRIVRNAHGNKTGYVFVDFQSEEEVEKALRRNKDYMGGRYIEVFRVDHALQGRAEGRGREERSWHRELKEDEEEEEVSESGRLFVRNLSYTCSEQDLSELFSKYASPGPLAETHFPIDSLTKKPKGFAFVTYMIPEHAVKALAELDGHVFQGRMLHILPSTMKKQKTDQDSDAQGSSYKKQKDAKDKASSGSSHNWNTLFLGTSAVADAIAEKYNTTKSRVLDDESRGSVAVRMALGETQIVQETRQFLLDNGVSLDSFSQAAGPRNTTVLLVKNLPAGVQVAELEAVFSPLGSLGRVLLPPSGLTAIVEFLEPAEAKRAFSRLAYTKFQHVPLYLEWAPMGVFTQPAPAKQEQPPTDSEQVPESESKTAAEAQSSEEEEESIPGCTLFIKNLSFSTTEETLKSVFSKCGAVKSCTISKKKDRAGALLSMGYGFVEFKSPTSAQKALRQLQHCTVDDHQLEVKISERATKPVVVSSRKKQMAKKQTTSKILVRNIPFQATGKELRELFSTFGELKTLRLPKKVSGTGAHRGFGFVDFLTKQDAKKAFSALCHSTHLYGRRLVLEWADSEETLETLRRKTAEHFHDAPKRKKQSEVMEDIMEQIEAGEEED
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAKLEKAANDLDFYKNRDETHPQNLNYEPPVEDFYGPVATELRFCTDLICIFIWIIFLGFSFAYGFYAYQEFKIERLYRSSDFRTDLCGIKQLEKKPYAYFLDPDNLFDIAICVEKCPNTIDYTQQICLYDTDGQTILEDYCYDTYYTDPYLVYCMPMELGQRRDAIEKIINTDMEIFKRIAGDFWINIELIVGAFAVQIVVGIIFVIILLGKRIAHMMLWGFVTGFCVAMVFLSKYLDEERYKVIQRDCPVDIKDPYQCVAAHLYLLEIAKQALLYLIPVYVFFLIYCFHQILRMIQVMERMLKPLRQMLHVLLIPFFISLLQAALAILFILVLMGGINSGAPETVSAPTGFSSTSYRKLVFQVWQERGFYVVLFFMLWTLQALYYYVRCYIACCCSVWYFSRDKNYLNAPMLRPLWYTIRYHMGSFLMGALLIPLFWIPNALFYYWKSMLVQMSRKSFLLHILLFFSIPGFWFYEYAGKYISHRNFMHIAIFGESFWIAGQKTFYLRERNSSRVEMIKKTLGFVRLIGMLFISSVGTYLVYYQLYTNQIIDRFVIDVKQAVHFPIVPAIYVFLVGLYISQNFSSIIDIVAEIMMFDLIAEEEMFMGKQRFADQDMLEFANKYSKEKQKSDFVVTNQGRINPMNEGDDANKALGKFDLGNLMEQDEEEPEELDPEPEPPVEEPKEKSIKSEHDDDFGRGNELDLDELGDMNNKNNDDQFDDELAEFNKQRAQDSNNKRKLEEDVINLDQNKQQADGAKKTDRRRF
The following text describes a protein:
Function:
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity).
Subcellular Localization:
Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex (By similarity).
Sequence:
MPCGEDWLSHPLGIVQGFFAQNGVNPDWEKKVIEYFKEKLKENNAPKWVPSLNEVPLHYLKPNSFVKFRCMVQDMFDPEFYMGVYETVNRNTKARVLHFGKYRDVAECGPQQEVDLNSPRTTTLERQTFYCVPVPGESMWVKEAYVNANQARVSPSTSYTPSRHKRSYEDDEDMDLQPNKQKDQHMGARQAGNVGGLQWCGEPKRLETEASSGQQLSSLNLSSPFDLNFPLPGEKGPACLVKVYEDWDCFKVNDVLELYGILSVDPVLSILNNDERDASSLLDPMECTDMAEEQRVHSPPASLVPRIHVVLAQKLQHINPLLPACLNKEESKTCKFVSGFMSELSPVRAELLGFLTHALLGDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSGCPRNSTFTEHLYRIIQHLVPASFRLQMTIENMNHLKFIPHKDYTANRLVSGLLQLPSNTSLVIDETLLEQGQLDTPGVHNVTALSNLITWQKVDYDFSYHQMEFPCNINVFITSEGRSLLPADCQIHLQPQLMPPNMEEYMNSLLSAVLPSVLNKFRIYLTLLRFLDYSISDEITKAVEDDFVEMRKNDPQSITADDLHQLLIVARFLSLSAGQTTLSRERWLRAKQLESLRRARLQQQKCVNGNEL
The following text describes a protein:
Function:
Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MKPVWVVILGWILLVPRVGTAQRGPPEEASFYHGTFPPGFSWGMGSSAYQTKDAWDQDGEGPSSWDNFTHGRKGQVLGGDTADSACDSYYKLQEDIALLKELQVSHYQFSLSWPRLLPTGIRAEQVNKNEIKFYSDFIDALLRSNITPIVTLYHWELPQMLQVTYGGWQNVSMTGYFRDYADLCFEVFGDRVKHWLTFSDPRTMVEKVYETGLHTPGLRLQGTGLYMAAHHIIKAHAQAWHSYNNTWRSKQHGLVGISLDCDWGEPMDIHNPDDLEAAERYLQFCLGWFANPIYAGDYPQVMKDHIGTKSAKQGLEMSRLPTFSLQEKSYLKGTSDFLGLGHFTTRYITQRKYPSHQGPSYQNDRDLIELVDPNWPEIGSPWLYSVPWGFRRLLNFAQTQYGDPLIYVTESGAPQNLHCTQFCDEWRIQYLKGYINEMLKAIKDGVDIKGYTSRSLLDKFEWEKYGFYYIEFNVRNKPRYPKASVQYYKEIITANGFPNSQEVESWRLKALETCSINNQMLATEPLLRRMHVPSEIVVPTVCVLSILIAALLLTLLLRSHS
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MASANTRRVGDGAGGAFQPYLDSLRQELQQRDPTLLSVAVAVLAVLLTLVFWKFIWSRKSSQRAVLFVGLCDSGKTLLFVRLLTGQYRDTQTSITDSSAIYKVNNNRGNSLTLIDLPGHESLRLQFLDRFKSSARAVVFVVDSATFQREVKDVAEFLYQVLIDSMALKNTPAFLVACNKQDIAMAKSAKLIQQQLEKELNTLRVTRSAAPSTLDSSSTAPAQLGKKGKEFEFSQLPLKVEFLECSAKGGRGDAGSADVQDLEKWLAKIA
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
Sequence:
MFKLEVPSLMVGTLDSLMNLSDDLGKTDSLIESVVRKVEKSSADLAGKKFNASELTVGGVPPTRYVQQFAWDYAKYPNRRPLKELVTLISSGVAAIDEELKQLSTSYGDKTVALQDAKRKKGGNLMTVDLNDVLDEKMVRGLEIHDSEYLKSLFVAVGKGQVEGFEREVYGMGSPVVPGSLIKVTQDNDSVLYMVTILQAFSKVLKEKRYIVREFTYDPSQQGKAAMHLEQLQVEVDNMRSGLTRWCKTHYGEAFVAWMHIKVIRVFVESVLRYGLPVDFTAVLYKVNSGKDKILVDSLDKAFGKGKEQEDVEDDGEEYHDFVLIKFDP
The following text describes a protein:
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence:
MEARRKKAEMRKREEEARKAEQPKVKQQEQPMVKGRSSSPAEDMGDENSGPPPEKTQEKSALSSFKSKLSAGRKLNIKTLMLKKAKEDLAQEAAERESAKRKYLEDVLPPLKLGGLSKDALESLCRDLHAQIEQAEEERFEAEYKVKKNDQEIEDLNMRIMSFTGRFKKPELKKVKVTPENMLNSLAESRRTKPGIIDFRANLKHVEREGHDSRRGSSSTTKSEGMEENLNGEED
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin; The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSFKFDWESLRDESFYERAKTILADALNSDSKPPIIVDDITVKDLDLGDESPFLEILEIGDMADDRFRGIFKLNYTGNASLTLTTKVQANPLNVYRQSFDQSSFVAPQFLAAGSSLAIPLNLTLSDIRLSGIIILVFSRAKGLTLVFRNDPLESIKVSSTFDAIPPLAKFLQVQIENQIRGLFRELLPGIIHRLSQKWVTRDETKSNSNTVMSPHVTQPPSPKLKPVSIMDINPDLPALSPTNMLKISALCASQRTLSLFTPSISDAVYRSNLEQFDVVDEESQFQSEDPYDIVRIQSRNYYRHNHQAPKRRTIKYKRKSKKTDEGDNASTEVTTRETTPLPTSSTPLETSTPSREVIREVKEKLLAEPSSVVMSPSEEKTTLRSIPPPLELSPPSLDLSIDTSLRPYASRNNTPEKKEKPQRPAGPSKRNTLPAPTKKGPGFFSSNLAGYDVPPPAYSG
The following text describes a protein:
Function:
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MGEKGESVAVIGAGLVGCLAALAFAKKGYEVSLFDYRSDPRLATTTDRNLRSINLAISARGIEGLKAVDDELAARVLRDMLPMHGRMIHNLAGKQEPQEYGLFGESVNSIDRGVLNNALLDEVSAQEHIQAQFGHKLVKANFNHGATQQLLFAVEGKTVQLEFDFVVGCDGAYSTTRQQMQRFDRMDFSQEYMDCFYLELYIPPTPEFSERFGGPFAISPQHLHIWPRHNFMLIALPNKDGSFTSTFFGPWSLLDRLDTREQLAAFLTTNFADAMELIGLDNAIRAFQENTKGALMCVECRPYHLPGGKAILLGDAAHAMVPFYGQGMNCGFEDVRVLMGLLDDYAGDRTAAFAKYTASRHRDLVSIIQLAKNNYRDMSHNVVSSWHRAKRSLNNVLGRTFRGTWLPLYTMVSFRADIPYHKAVEVDRRQAAILSLVQSALLSLAALGGFKGLLLLYRWIKQVRRV
The following text describes a protein:
Function:
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MLQNAFLLFFAVFWMAMYILDAVVKASRYGLKYAEFLGKHGVTISTAQIGWFTTYFNRFFIKIGSKQSTFFKIWFSIGVVFSLVLLIMSMFLLLMIIFNTFTGYSVEQQILTPVMPGINLPMNQVWFYLITLLVCGVLHEVGHALAAVGEDIRVNGFGIFLLLLYPGAYVDVCPHHVQSISAMRQLRIYCAGVWHNIVIVLLAVAFLICFPTFISLFYYSGRGVLVTRVNSDSPISGVSGVQVSDVIVQLDDCHVMNMNQWMNCITTVTKSTMSGYCVQKEIFHDFIVNVSNKTDADQLEDCCRDNSDGLLCFRHNHSNNKFGCLRARNVVEGRRCQQDEECRTSSHDDKHFGDRNFNSDDDNDINHININFAGSKNVTRNHLKRMSAICIHPHVDNVTWLVKVIYDDANNKQPLLFLGHPYDLFYSLSVSDYQPKWNYLPLHLPYILETFCKYLISLSGALAIMNVIPCYALDGQWITQATYNLLLPHLTSNKFIRDVTYTGTIMFGTALILVNVAIAFCTLFLR
The following text describes a protein:
Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity).
Sequence:
MELANTLRQDGESRGGVLAHLERLETQVSKSRKKLEEPQNAQALEARIHELKRLRDKLRAEVKQRQARVKASTANVEPDQILEISEQEILERKQENMKAILQAYRFTGISGKLTSRGVCVCISTAFEGNLLDSYFVDLVMEKPLWIHHHSVPVFIPLEEISAKYLQTNTRHFLFVLWEYLNAYSGRKYQADRLQSDFAAFLVGPLQRNSLCNLLSFTYKVKPEGQSFPFCARLLYKDLTTTLPTDVTVTSQGTEALPSTWEEQRAAHENLFFTKPLHQVFTSFAKKGEKLDMSLVS
The following text describes a protein:
Function:
Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. In vitro catalyzes the oxidation of both enantiomers of naringenin to give both cis- and trans-dihydrokaempferol.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEVERVQDISSSSLLTEAIPLEFIRSEKEQPAITTFRGPTPAIPVVDLSDPDEESVRRAVVKASEEWGLFQVVNHGIPTELIRRLQDVGRKFFELPSSEKESVAKPEDSKDIEGYGTKLQKDPEGKKAWVDHLFHRIWPPSCVNYRFWPKNPPEYREVNEEYAVHVKKLSETLLGILSDGLGLKRDALKEGLGGEMAEYMMKINYYPPCPRPDLALGVPAHTDLSGITLLVPNEVPGLQVFKDDHWFDAEYIPSAVIVHIGDQILRLSNGRYKNVLHRTTVDKEKTRMSWPVFLEPPREKIVGPLPELTGDDNPPKFKPFAFKDYSYRKLNKLPLD
The following text describes a protein:
Function:
Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK. Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation. Acts independently of MYMK. Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Domain:
The AxLyCxL motif is required for myoblast fusion.
Sequence:
MPVPLLPMVLRSLLSRLLLPVARLARQHLLPLLRRLARRLSSQDMREALLSCLLFVLSQQQPPDSGEASRVDHSQRKERLGPQK
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEPYVFLYPEQHIEEIQAAFEKFKSQVELFTEQPGEINQDFIRLIYDLSHVVHHHGFGGEFLEKCFAFLETHPESLSPDARSSLVQAIIVLHNHKVIDTVDLIDHFVPLFRLNDKNVRRTIYGHFFNRIPYHQTPQIKKELQKYVQHEDPRVSFKTLKLIIDIFHKENKEDPQTINFIARCIDLKNPRLVNAIVSFFLDPYTPKQESLIDEDDLEEMRREAEHQILINGKTKKNKKQLEKIKHMKASIPQDPVQVLGSLDDPLKLTIRLFSLLSQPEHVKIFKTRETQLRAMELISKLIFQFSLDFDKFFTWSERFIRPNYEDITKLLSIVASAVHSTTNVDTVAEVCRTIANNFVVDHLDEEVQIVGMNTIREICARNPHGMTPELLEDLTAYKKSDRKGVVMAARGIIQVFRENRPDILPKRERGKPTDDAEEPLAFGEQRSSNVLGELGEIAMTRLLTDEEIEKIKKGKADEIGDDDNNPDDSIIDETTLTEGSRVHKRTKEEIVAAAKEGKPEKHSFHNKKEDKTAGFSNKDKLKFKPFMLTRFRQESGRIKNKNLSAVQKDKKKREGKLKTLKMR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLLRASGKVALQPELRLVPRLVRFGSHHAHDEKIERKSDDYRPGSDSYAYENPWPKLNGGRLDWLFGDGWRRPLAKEQGAKTRREWIWFSQVAHDEHKDWLKMHQISFLLITVLTTWFTCWIMFARPDWPMGREWALREAHLEMARREKAGLPLISADLVSRSKIMKSLPSDEELRDFDVLI
The following text describes a protein:
Function:
Contributes to morphology determination of peroxisomes, but not to import of peroxisomal matrix proteins. Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer.
Subcellular Localization:
Cytoplasm. Peroxisome membrane; Lipid-anchor. Note=Predominantly cytoplasmic.
Sequence:
MANDTHTDDLDELLDSALDDFKDLNLTQRNGGVKKEEGDKKETESLPSGVQGLGMGLPDMRSKKKGKKKIAKEDHVTEALDKLREQTRETVKGLESLSSKQQPTGSDDAMVEDWIKQFENLTGSNDLESIVDTMMQQLLSKDILHEPMKEIGARYPKWLEEHESSLNKEEFDRYSRQYELIKELNLVYENEPNNSTKIMEIMQKMQECGQPPSDIVQEMDPGFDFASLGQMSPDMLESSPNCCVM
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MKLLNNLLLKRTSTYLVGIAGAVFFFERGFDMITDTIFESHNKGKLWKDIKHKYEQ
The following text describes a protein:
Function:
Cysteine proteinase inhibitor.
Subcellular Localization:
Secreted.
Sequence:
MEWKIVVPLLAVAFTVANAGLVGGPMDANMNDQGTRDALQFAVVEHNKKTNDMFVRQVAKVVNAQKQVVSGMKYIFTVQMGRTPCRKGGVEKICSVHKDPQMAVPYKCTFEVWSRPWMSDIQMVKNQCES
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MCSPRDSGLSMAAVRMMTRSRSWGPGAAPRRGGEEAAPLQRREAAAEGKKNPSLAKRQRKTQKLKVAYEAPGHEKGESHKALEALGWEPQDWRQQLENIRTMRSGKDAPVDWLGVEHCHDPSAPPKVQRYQVLLSLMLSSQTKDQVTAGAMQRLRTHGLTVDSILQTDDATLGSLIYPVGFWRSKVKYIKQTSAILQQRYGGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANRLRWTRTTTTSPEKTRAALEEWLPRCDRVGGWWGSPLCPSHTDLPALHRELWGEINGLLVGFGQQTCLPVRPRCGACLNRSLCPAAQSP
The following text describes a protein:
Function:
Calcium-selective channel required to prevent calcium stores from overfilling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASALSSLRYGDSLSVVGISAATAVLCEAMSWLLIYRTATYNSLRASIERHSRKLDAMKSGSTSASSGTAASSAQPASSRAKKMDRVETSLKDAARELSLAKLKSGAVVAVMLFVVFGLLNSLFEGRTVAKLPFAPIPLVQRMSHRGLPGNDPTDCSMVFLYFLCSMSIRTNLQKLLGFAPPRAAAAAGGGLFPMPDPKVN
The following text describes a protein:
Function:
Determines thylakoid architecture by inducing membrane curvature.
Subcellular Localization:
Plastid, chloroplast, plastoglobule. Membrane; Multi-pass membrane protein. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Located almost exclusively at grana margins.
Sequence:
MAISVAASSSMAVMVPRVPAVSTRCSAVPYLPPRSFGRSSFTVPLKLVSGNGLQKVELLKTRASSEETSSIDTNELITDLKEKWDGLENKSTVLIYGGGAIVAVWLSSIVVGAINSVPLLPKVMELVGLGYTGWFVYRYLLFKSSRKELAEDIESLKKKIAGSE
The following text describes a protein:
Function:
Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MSPPISPTPPPLQPPFPPTAIARGPDRPDPPPQHQQAAESLVNAAAQHVAPTCPPTSDELPQMEDQATNSSNDSLIPSRQAPDQEETENAITAGTPPDEMEPTKDAQTVRFSSSSPASYSTHEYPTEGINEPRTSSRAPNTASSQMAESSCDFRSSRDIGSIRMGASALVSALNALPWEEDDDSDDGEDDDEFIEPARGSSSTIYERKQRPQTPSTSHGFHPTHTLHFPFRQNAIARRACQPGTTELDYQYATPETSSRRTSAAGSESSSEGEVPLPKGFVSHPNLIVPSGEGEAAAHPDPKLISDRITKEQQIADVEEQAEILRSAEEQEMRLGKEFVPPKSRDSADLNVDAALREGGSEREDVIEEQMQTNEAEKRLTRNEKLAERLMEVFGLEEREEVLEEMKCWLLRSVMLKGYMYLTKRHICFFANMPNENNLLVKSGPLHKKASRSKLNTKFWVVLKNDVLSWYESTSDPYFPKGNISLQYCHSCDAVSGTRFKVRTSERNYTFTADTESSRDEWVKAIQKVMFKTQHEGETIKLIIPLEAIVDVEKSPTLEFTETIEVKCIDAEDQMSVDSYFFASFPDNDYAFSAIQKLVRERPSPPELPRISSVTTIHANQEPLDTSHATIKRHGTDSSAEKLGMASHRPFRKISSVLKPLILKSSDGEPLEEHSQGPHHNDEDASHLPHIEAISNRRRSEEESDNDYFDGYPPRQVGPPPPSMNDDARNWRPSWIRKPASKLFGSSPSGSFVSHPGRLPTDSSTTVTESGPSLRSRTGRTKQASVTEVMEPPIQYEEEVSEDEMSNKPSVVDSNSAETARKRAARLSWTSETSSGSQMVKSKSDFSMLGSESGHSESAETVRKFRTFFALSDKEELIDHFPGYLYRVLPVSGRFFISTNYFCFRSSQLLYKTKESFRLMIIPIRDLYGLKAQKAFRFGHSGLTVVIKGHEEIFIEFRSASRRKACIALLEERMEAVRLSGENTIVDSHKIEARIMEDLDESTPVEPKSPWPVSPSPLFGSTTSTSFLEFKPEPMKITCLTIGSRGDVQPYIALCKGLQAEGHITKIATHGEYKAWVEGHGIAFESVGGDPAELMQMCVDNGMFTVSFLKEGLQKFRGWLDDLLNSSWEACQGSDLLIESPSAMSGIHVAEALRIPYYRAFTMPWTRTRAYPHAFAVPEHGRGGPYNYMTYTMFDQVFWRAISGQVNRWRRNVLGLDATTFDKMEQHKVPFLYNFSPTVVPPPLDWTEWIHVTGYWFLDKADEKQGEKSWTPPQGLVDFIDKAHGEEKKVVYIGFGSIVVSDPEEMTRCVVEAVVNSGVCAILSKGWSDRGSKKGEPKGDSEGADGVKYPPEIFAIDSIDHGWLFPRIDAACHHGGAGTTGASLRAGIPTIIKPFFGDQAFWAERVESLNVGSSIRRLTSHQLASALIKATTDEKQISKARVVGEMIRKENGITRAIEAIYRDLEYAKSIIKSLPSTDDRTPERISSHLHPLTTADLSFNRVRSRSRSRSRSSQGRFSPRRHTVDDDGWSVVSGGSRSRSGSASAVTSPERRPLNIGSALGSHVFKTALLPNTFGKWRNLEEGDDR