lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MASNQQINTQLSKKLSWLLRHGAKTEGITIRADGFVSVPDLQKHPRYLCFTLEKLKEIAAADAKQRYTLRWNPELGVHEIRANQGHSLAVLEGEAGGLENITHVSQVPLAVHGTYYRHWGAIRSQGLSRMNRNHVHFACSDETNSTLSGFRSDCQILIYLNVEKVLADGIPIYRSSNNVLLCPGIEGFIHSSYFQRVVDKKTGQPLQIDHCY
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKNLELLELVHKGVPYPFTNVTLVSQTPQLIYYIRANSLHSHDLTCGETIQLGPPIFADASHLKSLIIENKTCVVVNNDLFIIALPNKFDKITFDKKIIEISWNPTEELVAVVFDDGEISTFCIDYENAEAFPQGKSSTDAGIPDTVYVGWGSKDTQFRGSEGKIKDQTPVETKPVFDQKPRISWRGNGEMFVVNYWKDQKRQFIVFETPCKALYRSEECPGLQPQVAWRPVGNMIAGLSVTNRQKIVIFEKNGQRRFDFDLTFDVMIKNLKWSPCAQILAIHTVTPTGQTIHLLTSSNYKWYEKQVLEFPAENALLDFDWLDTNQLQVVTQSDVIKYTFRNVVHHNSAAICGVIDGKHLNLTDFNNAVIPPISYARRFTNDKQINFVTFRHDLAMIIDSENDLKIFNVAEPDALLVTINLKKIVDLPQFALSCHHFLLSSESVYFAVTSDESVFYSLDWKNPQANFLTAITDNFSHLLQISGDYDNISGLKSLGNNLFINNNDSILCQIQTLGDQTYVCNLTSNNHFYLNEAKISDCANSFTLFDSYLLYTTKQSELFCLRLGQEGQNFRRNVEQGATIVCAVPNSPQIVLQLPRGNLETISCRLISIDILDKLLNEQKWAEAVRFIRLEKLNANLLFDLNPERFLRQIAHFVQGVHTINELTAICLEFEEGNVLTSIYKNWGKTTDFPQKINTIFASLFKYFDSVDYSVYITTIVAVNLNFFKLRDALIYLQDLYRRTNLKEKLLNAVNTLKIYGCDHEKLYTECLLLYDLELAGFIASCCQLDPRVYEPHLKQLSGLNEVEMRYEINLFAKKPKTAIIYLLRCPKAQTSDVLAFIKTHNVSRQAFENCPPKNRFYQSVSHAFAGDLSAKGCHTEAGVVLKRAGLPEEALAEFQLGLNWRQVLNLLEELNVDKVEKIKIVNDLATRLVQSNVRQAAILFEFYADNYEMAVKVLIEGFFFEEAIHIAMKHKRGDIIVSDVIPMLMKHKIYLEEKLQNLNESYNKYKQRLAQVRQQKFSRFNNDLDDCDERDDLFSDAGSTISKSSRSSRSRSSTASSRNRRKEEKKKQDLREGGIYEDIALIRALHSTIKEFYNKGEEVRNCCVLLLQESDVSYDEIKRIHDFYWKFDAEIQNGVAEIWPPHFYKNYQTLDVRELADLENFEHLDVEFRTPPGGRTNWKLNLF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MFVCKKCSRYVIKKIFYTFICESKYQLLFLRKGNDYKNIFFLEKGYISTHVRGDKKERTQKKKNDLDIKRLFLDKPSTPNIKDEYEKKTNDNNNMEEYNICNNNIITNNNKIKNSSHMNTFNSNRKKVCVKDNINNNTINNNYEEQKENKEEYINTPKAKNNLYNLPYKNKDTHIIDKKKLDEQVVKELHNLIISIKKIDKDKKENIIKYINTLNKKYVKNINKNIIVFFENLDIYMSVNGLLICDIGGEEIFNYINKIKLTNNIDIKKETYNDDIEKHNVNTNERFLHMDDVTKEDNININNMFDINYIKEKKKRIYGDNIYPIVVKSEEKEEVVPKKKKKNSNNIIVHNNNIINNKCGDYNIINCTNDLGEKTKNHQTNYSNNPKFDYQYNEEKEKEEEKESNIINVRRQMLIERSSYKKAIEEAEEFVSNLHDLKKITEIQGLCKIYLNWISELEKRIILYKEKNKNKKKKKIFPDFIDDKLLATITVKWTIQYTFNPLKKKYSNNVSTQSKYFEHEYSYQSLFTHIAIKIGEEINNELNFQLLEKKNHLYNYMKKNKNNSSFSHFQKYRIIKQMKQQIGKGNHMKQHAMLGGDNQTSHLNSCANNNFDINSCANNNFDINSCANNNFGINSCGNNNFGINSCGNNNFGINSCDEYYGHTNNHVHIKHDDDNIIEWNSVKKATIGGLLLNMLIENAKMDVDINVAKNEFKNEYKYYLFLHKTAKNNAEDLYEECKYKKELNYQKFYEEESNTLKFIILDKYKKNNSYDNNFKKNYMEKKICTYNYGTHDKNVVKQNNGDKQNNGDKQNNGDKQNNGDKQNNGDKHNCANRQELQLSDNKKESNFCQKQREKLMRKEIILYRSKRDRNKIELPVFIHSYVWKNNNWYGVIHMRECCANYLLNNAINSHIPLNYLPMICKPKRWENFEGGMLLLKNSFIRCNIKPLFNLNVCNLNRIKNIVSEIGNVGWKINKEILHYIEYAYIHGITIGKIPLYKNYTLPKYINLKEQNNEEIKKYLLLKEEINRLNKCLISERPTFLQKLAVAKTFKDNDIIYFPHNIDFRGRMYPLSPHLHHMSDDICRSLITFAEQKEIGNKGLFWLKIHLANTFGKDKLSFQKRIQWVDQNINNIKKLTQQPFDNIEFWNMAEKPWQALAVAIDLKNALESPNASKYKSSIPIQQDGTCNGLQHYAALGKDKYGGKAVNIIPSDEPQDIYSVVLDIVISKIKNDLMNISNGHHNNIISFSINENIKTNKKYNNNINNNINNYNNNNHNRNSNSNVNKNELASYCFKFDLLKRKVVKQTIMTICYGVTSIGAKNQVKGKIQTMIGKELDKNIINKLSQYIANYIFESISEIFKRAMIIKKWFNNLSKVTNELNIPITWISPIGLPCEQPYRLGNRILVNTPLQSISVISYKNSQLHKNKQRLGFPPNFVHSLDASHLMMTAEKMVIQNNFSFAAVHDSYWAHACNVDIMNQFIRESFITLYNEPILENIYNNFRIRLGKFATKIPSSPEQGELDISMVKDSLYFFS
The following text describes a protein:
Function:
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Sequence:
MSEGNWGHLDKNQIQRLEEMLIVVDENDQVIGAETKMNCHLNKNIEKDLYLVTQNLKIATKKSSEERNDTSLKSGRTYNIPHLYSPTSIKMKGTVFSPAFFGFKTFHRLLHRGFSVVLFSTENKLLLQKRADTKYTFPGSFSDSCSSHPLYNPLEMEERDAIGVKRAAQRRLHAELGIPLEQLSLDDITFVSRMHYKLQSDEIWGEHEIGYLLFVRKDVTLMPDAAEVKDCIYVTKEELEDLLKQEAKNKVKFSGWFHIIAKFFLFEVWDNLNDLNKFLKPDKIYRI
The following text describes a protein:
Function:
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Domain:
Has a putative N-terminal zinc-finger, a middle region with homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.
Sequence:
MANARSQYRCSECRHVSAKWVGRCLECGRWGTVDEVAVLSAVGGTRRRSVAPASGAVPISAVDAHRTRPCPTGIDELDRVLGGGIVPGSVTLLAGDPGVGKSTLLLEVAHRWAQSGRRALYVSGEESAGQIRLRADRIGCGTEVEEIYLAAQSDVHTVLDQIETVQPALVIVDSVQTMSTSEADGVTGGVTQVRAVTAALTAAAKANEVALILVGHVTKDGAIAGPRSLEHLVDVVLHFEGDRNGALRMVRGVKNRFGAADEVGCFLLHDNGIDGIVDPSNLFLDQRPTPVAGTAITVTLDGKRPLVGEVQALLATPCGGSPRRAVSGIHQARAAMIAAVLEKHARLAIAVNDIYLSTVGGMRLTEPSADLAVAIALASAYANLPLPTTAVMIGEVGLAGDIRRVNGMARRLSEAARQGFTIALVPPSDDPVPPGMHALRASTIVAALQYMVDIADHRGTTLATPPSHSGTGHVPLGRGT
The following text describes a protein:
Function:
Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus (By similarity).
Sequence:
MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYEIKDGSLLEVEKVSLQQRLNQFQHELQKNKEQEEQLGEMIQAYEKLCVEKSDLETELGEMRALVETHLRQICGLEKQLQQQQGLRDAAFSSLSPPAVPATACPDLDLHYLALRGGPALGHAGWPGPTSVSVSELERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSECGMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAGQRHSPLSQRHSPAPACPSPSPPARPPPCAPCQSPAAQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPGERTLAERAYAKPPSHHAKAGFQGRRSYSELAEGAAYAAASPAWLQAEAATLPKPRAYGGELYGPGRPLSPRRAFEGIRLRFEKQPSEEEEWAMPASPPSPEASTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI
The following text describes a protein:
Function:
Involved in the cell polarity process and in regulation of microtubule growth. Has a role in meiosis. Involved in microtubule dynamics. Binds to mitochondria and microtubules, attaching the tubular mitochondria to the microtubule lattice at multiple discrete interaction sites.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Microtubule-associated. Found on all cytoplasmic microtubules throughout the cell cycle, such as the interphase, the astral, and the postanaphase arrays of microtubules.
Sequence:
MLQRLEQLQMQTSNILKELHSTSIFTDSTTSQLHNGGENSVMDTEESSAIDKLSASLQQVNISSPSVPTSQSRVTQGQSLGNTQISNPTSKTNNVRAKARNIRNPSQRLRPSTSLARLSNNAPRIPKEASLHENSISSKESPSVTTSKHVATITKPSTSSIARMSSNARIAAIPRAKSSMAVRSPSRLGNGPNVRSPKVGFNAKSDDSPVVKSPGSNDKPSASPRISVRSLGNSSVVRPPTRTSTTRPLSRVNVTNASGSISKNSTSPSKVKVNASTKIVRPVSAAQTVRPGSRIFRENSASNTQRPNVSATSNSTVRVASSLAVRPVSRNAQARTPSRLEQREVNVKNSSAKIVRPGTSLGVRSPSRIQSTLSSRTTTGNVRTKAANIVRPSSSINRRPPSSINQRPPSNLRILAPSRSRATIHERPSSSILHRHAHSLTSSSFSTKTLATTKEIQNSPTLVESSTVVHHDPSYLQNQTSEINDTNHSSHSSPLDLNRMI
The following text describes a protein:
Function:
Subunit k, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (By similarity). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (By similarity). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MAGAESDGQFQFTGIKKYFNSYTLTGRMNCVLATYGGIALLVLYFKLRPKKTPAVKAT
The following text describes a protein:
Function:
Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular Localization:
Nucleus.
Sequence:
MEKTGGKFVLEWETHSKQISRGLCMLMERQCLVDIAVCCGSNTLHAHKCVLAASSSYFKEHLENKAIEQVVINGLDFAVMKSLIEFMYSGECAFSEDHLKYFIAAVKFFKITALESIFAENEYQNISADEVCIPPPQFICKPPKYPTVYKPFSNASLPPKINYALSNVYGQHKFKRKCLGSEAEKACAKEAQASRIALANLRKVMASTPQVHSFIVEESFNETTVENFIPNVEENFVENIHDVQFVNGNAPPATANGKPLSVIPVSNTQSLTADKIKHILGNDEVEIMFQTSDGNFVNVSDEVLLNLSKGGLQYQVVDENGHIGEIQELKTLDSENGPKDDQDLKTETFDLKIIKNPDEIDKIAKAMPEEYIDPNFSSAACNKTNMESLQLHTSFNEDLYENSFHMQSAEMFEPENLSMHSDLMADNAMEFESDLKYKYLTSKINNTHDTINFDEHIITKIDSMSEDPLRDTNEVLVMETDTTKSPQNKSSLKFTPDMFFTTLPANACTEDKSKIPAVNDVAE
The following text describes a protein:
Function:
Part of the general transcription factor complex TFIID (By similarity). Plays a role in recruiting taf-4 to the nucleus and thereby activating transcription initiation by RNA polymerase II, as part of the TFIID complex.
Subcellular Localization:
Nucleus. Note=Localized to nucleus throughout early embryogenesis.
Domain:
The histone-fold domain mediates hetero-dimer protein-protein interactions.
Sequence:
MKMEEFSPPTSPNNHVIVQANPQIAAALSTNSPMQQGIPPQGHQNPNEQQQQQQFVGQPPMGGMGGPMRMQMPQQQIRQMPYPSPQMRAGPPPPQQQQQQHFQQMGIPQQQQPQQFTPNGQSMQMQQRPMQMGMAQGPGPSGHLMGMVGGPPPQHMMQQQGGGGPPQFVPNSSPMPLPPQQIMQVQHQQQHQQPPPSQQIQQPPIPQPQQQQAPPPQMIPAAVPYGSIMEKSKLDDLMQQISSTTVLEENVKDVLVEYADDFVSSLIDKACKMIKNREVKKIESRDIEFILKNVYNMPVVPRAASHNFGSQTEVIDLSKEKFVPTEAHKQRVALLKKQIKKL
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Membrane; Peripheral membrane protein. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Sequence:
MTLNLCVLTPNRIVWDSEVKEIILSTNSGQIGVLSNHAPIATAVDIGILRIRLNDQWLTMALMGGFARIGNNEITILVNDAEKGSNIDPQEAQKNLEIAEANLRKAEGRRQIIEANLALRRARARVEAINVIS
The following text describes a protein:
Function:
Involved in nitrate transport.
Sequence:
MAIKKLLFASLLICSMIQSSHGATKERLFTDLEKGALEITATPSRTGEGVVLAAGIDKLSITWKVSSTATKEPEFKTIKVKLCYAPISQVDRPWRKTENELFKDKSCPHKISSFSYDPTVKTAQSFDYTLERDIPTGTYYVRAYAVDAKDHEVAFGQSTNQDKTTNLFSVQAISGRHKSLDIASVCFSVFSVVALLVFFVNEKRKAKIEQSK
The following text describes a protein:
Function:
Involved in the degradation of phenanthrene. Catalyzes the oxidation of cis-phenanthrene dihydrodiol (PDD) to yield phenanthrenediol. It can use either NAD or NADP as electron acceptor, however NAD is preferred to NADP.
Sequence:
MAWLEGQSVFLTGGVAGLGRALVKRLVEEGANVTVLDRNARGLDELVESFKGRVAGSPGDVRNLADNRKAVELAVERFGKLDTFNRQRRHLGLLCPPCRPAGRCHQRSFDEVIGINLMGYVMGIKAAAPALVRSRGSVILTLSSSAFYAGGGGVLYTVAKHAAVGLIKQAAHELAPYVRVNGVAPGGIASDLRGPKSLGMGEQSITSVPLADLVKDIAPIGRLSDTEEYTGSYVYLASARNSAPATGVIINCDGGMGVRSVLGPASGGKGLLEKFGG
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MDVEDGKKIPLGPRCYFSNFQESFEKVDYPKGDLNSVCITKSDFDLLKPDTFINDTIIDFYIQYLKSKIQKEESHRYHFFNSFFFRKLVDMDRNPSSASDGKAAFQRVRRWTRKVNLFEKDYIFIPVNFKLHWSLIVICHPGEVVKFNDKEPDKALKVPCVLHMDSMRGYHSDLKNIFQSYLWEEWKERQKDTCGEDLSSRFLNMHFLSVPSPQQDNMFDCGLFLLHCIELFLDEAPFNFNPFKLTKFSNFLNLDWFHPVEVSLKRPFIQRLIFELAENENHSLHEGFPSDYNEDHRYSENNKNRTNSLRPEVNGDSSLSHSVQGKQFTLLSAPSPLDPQSFNPSDMVLKEHFKPGTMAGTSRGHCQSLDQQSSDHYLNGSIFSTKDGTDLNEELMHIMANPNFQQVSPQSFSLTYLTGGCETEISHGPRIGIQSEHDKIESFIATPSCASGDSDIEIIENFPTRNETRSSYEDERGENNNTAIENYIEQVSDIPGSLMENSQWPNTNCVGHNNGDQHLSYIQSEHSKTKPSQATSTCAYASDDIAMIGNFPIINETRSPYEDEQGEKNNTAIEDYFEHFPEIPDSHMEFSQWPNTSTYASANPDNIAITESFPIRNETGLSYDDQRAEYNNAAMENFFEHLPEIPDSLVEFSQRSNPMCVSDNNGDQGLYCQETPAMQMDQVSNALDDKFTCDDDDLVIIDSMEPDHWKNQPIKKRRMLR
The following text describes a protein:
Function:
Major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell. Produces the wrapped form of virus that is required for cell-to-cell spread. Acts as a lipase with broad specificity including phospholipase C, phospholipase A, and triacylglycerol lipase activities.
Subcellular Localization:
Virion membrane; Lipid-anchor. Host Golgi apparatus, host trans-Golgi network. Host endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Note=Component of the inner side of the enveloped virion (EV) membrane. F13 is associated post-translationally with membranes.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. F13 contains one L domain: a YPPL motif, which might interact with PDCD6IP/AIP1.
Sequence:
MWPFASVPAGAKCRLVETLPENMDFRSDHLTTFECFNEIITLAKKYIYIASFCCNPLSTTRGALIFDKLKEASEKGIKIIVLLDERGKRNLGELQSHCPDINFITVNIDKKNNVGLLLGCFWVSDDERCYVGNASFTGGSIHTIKTLGVYSDYPPLATDLRRRFDTFKAFDSAKNSWLNLCSAACCLPVSTAYHIKNPIGGVFFTDSPEHLLGYSRDLDTDVVIDKLKSAKTSIDIEHLAIVPTTRVDGNSYYWPDIYNSIIEAAINRGVKIRLLVGNWDKNDVYSMATARSLDALCVQNDLSVKVFTIQNNTKLLIVDDEYVHITSANFDGTHYQNHGFVSFNSIDKQLVSEAKKIFERDWVSSHSKSLKI
The following text describes a protein:
Function:
Tuberculosinyl transferase that catalyzes the condensation of adenosine and tuberculosinyl diphosphate (TbPP) to generate 1-tuberculosinyladenosine (1-TbAd), which acts as an antiacid that directly protects M.tuberculosis from acid pH and physically remodels M.tuberculosis phagolysosomes. In addition, acts as a phosphatase that catalyzes the diphosphate-removal from TbPP to produce both tuberculosinol (TOH) and isotuberculosinol (iso-TOH). Has broad substrate specificity, and can also use the 3 labdadienyl diphosphates, copalyl diphosphate (CDP), ent-CDP and syn-CDP in vitro.
Miscellaneous:
MISCELLANEOUS: 1-TbAd is highly prevalent among patient-derived M.tuberculosis strains, where it is among the most abundant lipids produced.
Sequence:
MNLVSEKEFLDLPLVSVAEIVRCRGPKVSVFPFDGTRRWFHLECNPQYDDYQQAALRQSIRILKMLFEHGIETVISPIFSDDLLDRGDRYIVQALEGMALLANDEEILSFYKEHEVHVLFYGDYKKRLPSTAQGAAVVKSFDDLTISTSSNTEHRLCFGVFGNDAAESVAQFSISWNETHGKPPTRREIIEGYYGEYVDKADMFIGFGRFSTFDFPLLSSGKTSLYFTVAPSYYMTETTLRRILYDHIYLRHFRPKPDYSAMSADQLNVLRNRYRAQPDRVFGVGCVHDGIWFAEG
The following text describes a protein:
Function:
Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level.
Sequence:
MSSALDEFAKSSLEITASDIIYDEEIDFVGRGQFGSVYRAQIKGLNVAVKVSHETKFSTDQLKSFVTEMDLMKKCHHPNVVLFIGISIDSGRVMLITELLDGDLAQLIHRRDESLHPEIYSCVLTTELKLNIIEQCCKGVQWLHNGMNLIHRDIKPANFLIDTSFHVKVCDFGFAEIDTNQTKQAKGSPLYCAPEVWEKKCEKAVDVYALAITMWELFYERLPFEEFLKDPDKFRTFISNKGRPILPNTFEKGVIKKGEEKAMASTLMKMHQKYGDLAKAIPDYIEKIMECAWEHDPTKRIDINIMVDMVDEAKLSYTLGKKSASVWWKKYFSCKGNDIETSVPVSDFIDALKDTHGIKDFDQYIAEQVLSDNNEVSTAFFGHLIHLFGVFYKSKDVFKSMIETIQSDWFFNTFTKDQSQAQLEGRVDGTFLIRISTTDPKYPFTLTKRTNGKTTHSRIERVSPSKDKIKFILSSKTKVYEANSLKELVDMMRKNKLVKEACPREEKLSEY
The following text describes a protein:
Function:
Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR. Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy; Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR; Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion inner membrane. Mitochondrion outer membrane.
Sequence:
MWRIHGLVGRVLNRCHVSTPLRLSQGHHVEDDVLNSSSLLSSGLHPFDSSSQRGENGDRQRNERTFHYYSARLPRYTALDAVGWGAATVLFLQVFRRIHSQFSSPSDKGQYREPLQVHRCSYRALLEILSCHNALPRSINARCLRSLETGSSEDSTADLSSSASLNQDTSVTDLEDGLSAVIADSEDAEAFENLTENNSLPPEEGLTGAANNFKSVTESNVPIILNIIGLENAKRGDYCTAFSCFLAAAKHNYSKAHFNVAVCYEKGRGVAKDMEKAAVYYRQAAAAGHSQAQFRYAKYLLHSKEQQDPQDSSRAIAMLEKAAASGVREAQAYLGVLFSQEPQRNGKKAVHYLQMAAKNGDAQSQFNLGQCYEMGFGVQRCYMTALDHYQQAAAAGSEQACCMLRALWGQGEGGRGLSEDVMLRSVSSSPCFSGAETFSQRRDHASKTKDPCGPNRISRTLPHSWSTDSIHTLPMINVTSSVLAELSEMDEALKSCRLSKPRHCSWTIGVG
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MTTSWLNIWNPVLINRSNRPILQENEYNIYIRDNVGLYQGRQKIINHQNGRVYLTNKRLIYFDNNDSSRSIAVELKLFKNAELVAGYFRRSPKVTLYIKTENSDTTNIGGNDSGSNTKNIAIDWVCKICSFNNHLAADYKLNENELPKCTSCGIRPSKSYLMQILDSAQNNIPIREDSPASMTPEPESVSPNNDNQCPKCTFINHPALRYCEICGTELKSSNNNNNNNNTKLFKVTQSLSNVSINSNPSNLKLETGEESYTNNQPYIKLSFRKGGESKFYQEVCKVLDDIKWQILEEKGGINKNAVKLVDNSSTVNNNNTASGGGGGGIHALERLGELQRKQNEMILTTSLDDLEQLMFKYQDLIKLSTSFNKLIKQPPSTTSGVVIPALSIKKSSPLYHQELSRHISEFSINFKLTQKTSMISSQDLFAEYNRFLIRNQGFGSELVNCDDFKCAIELFEKLNLPVVVKQYVNSDIYVIRPKVNANIYGEHIVQYLKDQEHEYKLMTLQREIISGDYENINNDLYNAVNYGKTVSEISNKFNWSYNITIEELEKCVEEGSVVIDHHISGTFYYVNKFSFSETEWDDTKEIQEMRELLIKEQQEITISLRNEYDKQNMDNLVNIDPDYSFFGAGNNDKEDDLESTVTTSVSQSQTQSFNDLIGLQF
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MTDYCIFNISWMSDRFGCETGNEDVQECIDKSPNGSPTTSTTHRRQNSSSGLEPARKRPKLSPPVLTAMPLDLTDAVSPNESQACTSSLKGVVTAAGAAQMSVADRMTSSSVAPPLCIVPRSVEFINPKTEDMSMDIPMGNVQSEFTGLKCRVCGDSRAGRHYGTIACNGCKGFFRRSIWEQRDYVCRFGGKCLVVQEYRNRCRACRLRKCFTVGMDARAVQSERDKHKKNPKDSNNEGSTSPQYPTASTPISIPSTSTSQTPTSSVNSYNFQNIPGIVSRSFSENLIMRDNSVPVMETSQSAALSHVPLVRYLIDLEKATDNLIDENCDFMSMEFDQLCRVDVTIEAAFRQPGVVAKRTPPRWLALERLTTLEDVHIAWCRSFVLCIDYAKIMKDYQELSPTDQFTLLRNRVISVNWLCHTYKTFKAGCDGVALVNGSWYPRDKELQKQLDPGCNHYFRILSEHLMEDLVIPMREMDMDEGEFVILKALILFRAHRRLSEEGRAHIKRVRDKYIEALYQHVQHQHRHFSSVQTSMRISKILLLLPSIEHLSQQEDDNVQFLALFNLANLNGLPYELHSSIKQHIPNGDDSDDTQVNEVTSNNDGPRSSESSHTPQSVSTSQFLEFKPSLH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAETSEKNDDFLLPIDPEALQDSLLAVDSENSLATVIPKIVKKYGLFRSLTESDLREKSEQEEQSQEVQEKAKPTPAKQPTAEEQGLDNLSAHKKELIDQIAMAQNECSLALDMVSLLLSKYRTNSVDTISPFLENAVSLGSLTMNRCEAPKAKSSDALVGKLWKDKALKNARTSFTAAAQRLRNVVEGEQEKWNLFARFHEKGWPILRGKDGALCVQYSALGGQSVGVGTFDLSSKKGKPTFVHGLQYEHASLKVDIHRRDEIVASNRWSWPDEHKTEEDDVEKQLHQARRTLFEMDVWNALLLEAQYCGNQGVIYTGNSIEVTYDGTYKTSISLSPVDSGADEHHKNDLSSDSMNVDDKDVQLRELCLVFNTLIHVLFVQYCRETQKFSLKHLRQNPIPASILRPLIFLFSTNRLAHSFQTWLQEHNIPFTYEAEYPWTKAKSLEELERALMNPKVRILWKLKCKEYYEPACIEQTPVMQGTEKFIWKWQDACASLKFQDMSNLCQYIEYYLAEKNH
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MNEGTIIDLPIWIADVLSQSEYDPYSGNQECFVTVKIPHALKPSVLNALKTDAPGVDLRYQSPLFFALAIYYLELFEDEELETIIATAMAERISDIYDNVGRRGEFVHKYDEFEKMLYKKGCASRRAYKEYMATIKY
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MGGLIDLNVTEEEDETLSSASGSLSTSNSSSSAFVANGSSSSSSSSGVCLELWHACAGPLISLPKRGSLVLYFPQGHLEQQAPGFSAAIYGLPPHVFCRILDVKLHAETDTDEVYAQVSLLPESEDIERKLREGVIDVVDGGDQEDYEVVKRSNTPHMFCKTLTASDTSTHGGFSVPRRAAEDCFPPLDYSKPRPSQELLARDLHGLEWRFRHIYRGQPRRHLLTTGWSGFVNKKKLVSGDAVLFLRGDDGKLRLGVRRASQFEGASAFSAQYNQNTNHNNFSEVAHAISTNSAFNIYYNPKSLGIITGISDLDPIRWPGSKWRCLIVRWDDNEANRHQQRVSPWEIEPSGSISSSGSFMTTGPKRSRIGFPDIPVSEGIHATDFEESLRFQRVLQGQEKFPGFINTSSDGGAGARRGRFKGTEFGDSYGFHKVLQGQETVPAYSMTAHQQHGLSQGNFSSRFLPPSLVHVSSSPSSVLITNSNRPNGRLEEHQGGSGSRCRLFGFPLRDESTAMVVPCVEGQKGVSGVQSNHHSQGRGIYGMRDMLLDIAL
The following text describes a protein:
Function:
ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape.
Subcellular Localization:
Nucleus.
Sequence:
MSLELKPDAHRRPLWVCHNGRIILEAFSPLVTQAQDFLITIAEPVTRPSRIHEFKLTAYSLYAAVSVGMSTDVILDVLERFSKIAVPNRVIQFIKECTLSYGKVKLVLNRNKYFIESSYPEILRILLASPVIASARVIRNDDDQTDLNNLNPSTLGHINNHSHSIMDGFKKLGSIASNNTKLDPWSAKRLKLVTNGADKEDVDAQFEDDDDDADAIANSATHARDGLTEKGSNLILDDESDFTQSFEIASHMAEEVKKKCTELDYPLMEEYDFRKDDINEDLDIDLSPKTTIRDYQEKCLSKMFGGGASGGRARSGIIVLPTGAGKTLVGITAACTVKKSTLVLCTNALSVEQWANEFRKWSTLQDHQIAKFTADSKQRFAGNSGVVVSTYTMISHTGKRAYDTQKMIEFVNGHEWGLMILDEVHVVPANIFRRVLTTVAAHTKLGLTATLVREDDKIEDLNFLIGPKLYEANWMDLATRGHIAKVEAVEIWCPMTGDFYQQYINSKPGKRRLLCVMNPAKFMAAQYLIKWREKQGDKIIVFSDNVFALEYYAKALKKPYIYGGTSHEERSRILNYFRNNHPMFRTIFLSKVGDTSLDLPEATCLIQISSQFGSRRQEAQRMGRILRAKRRNEEGFKSRFYTLVSKDTDEVVFSARRRTFLVDQGYEFHVVPNYLSMIPEEDRGELLMSQYSDQVKLLQLVKQQTEEVGMDEVVVAEADDLAGVWMSQSGSMGKRGVANRRGRGGSSTNGRPAAVGKKSHSLFKAWKAK
The following text describes a protein:
Function:
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSFESFGDFLAMGHHGPYVWSAYGISLLVLAINVAEPLLARRRYLQEEARRLRREAQQ