lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source.
Sequence:
MSELSQLSPQPLWDIFAKICSIPHPSYHEEQLAEYIVGWAKEKGFHVERDQVGNILIRKPATAGMENRKPVVLQAHLDMVPQKNNDTVHDFTKDPIQPYIDGEWVKARGTTLGADNGIGMASALAVLADENVVHGPLEVLLTMTEEAGMDGAFGLQGNWLQADILINTDSEEEGEIYMGCAGGIDFTSNLHLDREAVPAGFETFKLTLKGLKGGHSGGEIHVGLGNANKLLVRFLAGHAEELDLRLIDFNGGTLRNAIPREAFATIAVAADKVDVLKSLVNTYQEILKNELAEKEKNLALLLDSVANDKAALIAKSRDTFIRLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDNNVEIHCLIRSLIDSGKDYVVSMLDSLGKLAGAKTEAKGAYPGWQPDANSPVMHLVRETYQRLFNKTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGHYWTLLTELLKEIPAK
The following text describes a protein:
Function:
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.
Sequence:
MTKPKKFINDAATAVDEFIAGLLLQYPNHLRKLANHHVLLHSSFANDDHPNTTRVSLLSGGGSGHEPSHAGYIGENMLSGAILGGIFASPPVSSILAAIRAVTFVGGKGALLIVKNYTGDRLNFGMACEMANAEGLAVKMVVVADDCAVARTKGITGARGVAGAVLVHKIAGAAAGRGFGLNQVAKVAETVAKSVGSLGVALEAVTIPGADMINDRLSAKGELMMEIGLGIHGEAGMRQCPLLSCDDIAKEMLSAIQNYGREINGKIVPLYDSGDEVVALVNNLGGASNFEMSLLARSLVTQLEKDARCKVTRVLVGSFMTSFDMQGASVSLLPLTGAMASDDMLSLIDTDTDAPAWAKADVWKNAGTSPRPSEIEIDEVYKGAPSDTATAGVAPLPIVLVENFATVAREIISKCCDDLINAESLLTKYDTIVGDGDCGITMQRGANEISKRLKSQQLNVEHPALLFSDLADAVSASMGGTSGILLELMFRKASTTLASAANEGIKSRDLALAFRAGAEAVSFYGGAHEGSRTMLDALFPASVALLGIDESAVDVEGAAKAARKGADATASMDHADAGRSNYLSKEQLIGTPDPGAVAVSIVLEAMSQVLS
The following text describes a protein:
Function:
Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also mediates cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity).
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a secreted soluble form (isoform 1 only); [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium. Cell projection, filopodium; [Soluble KIT ligand]: Secreted.
Sequence:
MKKTQTWIVTCIYLQLLLFNPLVKTKGLCRNRVTDDVKDVTKLVANLPKDYKIALKYVPGMDVLPSHCWISVMVEQLSVSLTDLLDKFSNISEGLSNYSIIDKLVKIVDDLVECVEGHSSENVKKSSKSPEPRLFTPEEFFRIFNRSIDAFKDLEMVASKTSECVVSSTLSPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKATNPIEDSSIQWAVMALPACFSLVIGFAFGAFYWKKKQPNLTRTVENIQINEEDNEISMLQEKEREFQEV
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Considered as a meristem identity factor required for normal growth of the young floral meristem. Acts together with LEAFY to positively regulate the B class floral homeotic genes APETALA3 and PISTILLATA. In this way, operates as a region-specific regulator for petal and stamen development. Alternatively, may play a role as a negative regulator of the C class floral homeotic genes. Interacts together with the SKP1-like protein ASK1 to form a ubiquitin E3 ligase complex and could indirectly promote the ubiquitination and degradation of specific proteins controlling the floral primordia development like repressors of B class floral homeotic genes.
Miscellaneous:
MISCELLANEOUS: Mutations in the UFO gene result in the formation of unusual floral organs.
Subcellular Localization:
Nucleus.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MDSTVFINNPSLTLPFSYTFTSSSNSSTTTSTTTDSSSGQWMDGRIWSKLPPPLLDRVIAFLPPPAFFRTRCVCKRFYSLLFSNTFLETYLQLLPLRHNCFLFFKHKTLKSYIYKRGGTNDDDSNKAEGFLFDPNEIRWYRLSFAYIPSGFYPSGSSGGLVSWVSEEAGLKTILLCNPLVGSVSQLPPISRPRLFPSIGLSVTPTSIDVTVAGDDLISPYAVKNLSSESFHVDAGGFFSLWAMTSSLPRLCSLESGKMVYVQGKFYCMNYSPFSVLSYEVTGNRWIKIQAPMRRFLRSPSLLESKGRLILVAAVEKSKLNVPKSLRLWSLQQDNATWVEIERMPQPLYTQFAAEEGGKGFECVGNQEFVMIVLRGTSLQLLFDIVRKSWLWVPPCPYSGSGGGSSGGGSDGEVLQGFAYDPVLTTPVVSLLDQLTLPFPGVC
The following text describes a protein:
Function:
Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4-naphthoquinone.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSGSPLRPWLNSFNPLIYTASVIPILVGTAFAWWQGGVFDLQRFALTLAGLVFVHAWINLTNDVFDWDTGVDRNKLNSLVRTTGSRSQVLWVGNIFLSIGYVCFWALQDWWLLAFGSLGIFLGYAYQGPPFRLAYKGLGEWISSSCFGPIAVLTATRAQTGSWELGALLAGIAVGSWTATILYAHHFYQYEDDREFDKRTPVVRWGPELAAKRFWWVISPSYVVLLLAVIGGFLPWTVLAALATIPLAVSLVSFVRENATNPAVVVGALPLAARFHLVSGALLTLGLLAGTLLPR
The following text describes a protein:
Function:
Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons.
Miscellaneous:
MISCELLANEOUS: In one-eyed pinhead (oep) and cyclops (cyc) mutants, expression in the ventral forebrain was eliminated. Overexpression induced ectopic dlx2 and dlx6 expression. The tof mutant has a reduced number of tyrosine hydroxylase-positive and dopamine beta-hydroxylase-negative DA neurons.
Subcellular Localization:
Nucleus.
Sequence:
MASSLPLETVMSCPRLDDRSGATAAPKSLAFSIDRIMSKTSEPKAAAAEERSEGKKTVGLCSPIPCMIPIQPFSYDLQAKALMNYSEFWKVNFRGALCTSAAMCKTNCGVCSKADAGIKHSVLPGTRVIKPQVIHQALAMPANGSLCYFNYLDSAYQSELLSGHLFSSAIANSQAQAISAHQKLLLLENAKLACVSPEKFPTPQYPHKEHLPGQLDQIVRESHNLTEKNGVKAHSKTNNCSSDGKPKNFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQEKPHKCNQCGKAFNRSSTLNTHIRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTHSGEKQYKCSICSKAFHQIYNLTFHMHTHNDKKPFTCGTCGKGFCRNFDLKKHIRKLHDNANCLSGGNDSSRGHQN
The following text describes a protein:
Function:
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Sequence:
MSKLLRVGVFMPAFKWERMNLNQVTPEKHGIELVPVELGDDLSSFDAIIHKFTYQLVDGHEADVAKIQEYAKNRPGFVVIEPIDNIRVFVDRLALQNFIEHNPLPDCVEYIKGYPVDDNFKPENVGLHYPILLKPVAACGTSNSHSIQVIHNEEQLRAVGNPYPMLAFPFIPHHGVVFKCYSLGENFVMHKSKSLVLKTQDKVVFDSQKPLPTEIDAGAVPDDAASYEPSSEELKASSEALRKMTGVQLIGYDLLRRESDGKLCLVDFNYFPCFRGIEDVPGKFATFIKQRIADAK
The following text describes a protein:
Function:
Alpha-L-arabinofuranosidase involved in xyloglucan degradation by mediating the cleavage of terminal non-reducing alpha-L-arabinofuranoside residues in xyloglucan branches, converting the 'S' units to 'X' units.
Miscellaneous:
MISCELLANEOUS: Gut bacteria supply the human body with energy from dietary polysaccharides through glycosidases that are absent in the human genome. Xyloglucans are a ubiquitous family of highly branched plant cell wall polysaccharides present in the vegetables we consume. Enzymes involved in xyloglucan degradation mediate the conversion of otherwise indigestible plant polysaccharides to short-chain fatty acids.
Subcellular Localization:
Periplasm. Note=Periplasmic localization is predicted by analogy with the archetypal sus locus.
Sequence:
MRNALFLIFISLCSVCKSSAQGYSNPVIPGFHPDPSVCKAGDDYYLVNSSFQYFPGVPLFHSKDLVHWEQIGNCLTRPSQLDLTNANSGSGIFAPTIRYNDGVFYMITTNVSGKGNFLVHTTDPRSEWSEPVWLEQGGIDPSLYFEDGKCFMVSNPDGYINLCEIDPMTGKQLSSSKRIWNGTGGRYAEGPHIYKKDGWYYLLISEGGTELGHKVTIARSRYIDGPYQGNPANPILTHANESGQSSPIQGTGHADLVEGTDGSWWMVCLAYRIMPGTHHTLGRETYLAPVRWDKDAWPVVNSNGTISLKMDVPTLPQQEMKGRPERIDFKEGKLSPEWIHLQNPEAKNYIFTKDGKLRLIATPVTLSDWKSPTFVALRQEHFDMEASAPVVLQKAGVNDEAGISVFMEFHSHYDLFVRQDKDRKRSVGLRYKLGEITHYAKEVSLPTDGEVELVVKSDINYYYFGYKVNGIYHDLGKMNTRYLSTETAGGFTGVVLGLYITSASKDSKAYADFEYFKYKGKPGENK
The following text describes a protein:
Function:
Acts as a component of a SCF E3 ubiquitin ligase complexes.
Subcellular Localization:
Nucleus.
Sequence:
MRGAGIAAGRDDSGAGARIRGENSGPGGCSHMDGLPGELCFKIFHLLDHQALAAAPQVCRKWSALSCDDELWRKLFEDRWGADATAFYAPEPEGSKPWKDVFVVQDRCDRYGLGVRIIREGNDYYLIYQGEIQSYLGTSCDAKDAQPQGAQADKRQISDRILFFLGDLETAYADAKRVEA
The following text describes a protein:
Function:
Omega-3 fatty acid desaturase that recognizes a range of 18- and 20-carbon omega-6 substrates. Introduces a double bond in the fatty acid chain three carbons away from terminal methyl group to biosynthesize n-3 (omega-3) polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes). Acts on a number of substrates like linoleoyl-CoA ((9Z,12Z)-octadecadienoyl-CoA, 18:2n-6), dihomo-gamma-linolenoyl-CoA ((8Z,11Z,14Z)-eicosatrienoyl-CoA, 20:3n-6), and arachidonoyl-CoA ((5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA, 20:4n-6), to generate alpha-linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA, 18:3n-3), (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA (20:4n-3) and (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA (20:5n-3) respectively. Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity).
Miscellaneous:
MISCELLANEOUS: HPO-19 and T05H4.4 are cytochrome b5 reductases required for PUFA desaturation in Caenorhabditis elegans. HPO-19 knockdown or mutation alters FAT-1 desaturase activity. Although FAT-1 lacks a cytochrome b5 domain, its N-terminal contains a DUF3474 domain that may possess some oxidoreductase activity for electron transfer, obviating the need for an extra cytochrome b5 enzyme, but still requiring cytochrome b5 reductase HPO-19/T05H4.4 to become activated.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVAHSSEGLSATAPVTGGDVLVDARASLEEKEAPRDVNANTKQATTEEPRIQLPTVDAFRRAIPAHCFERDLVKSIRYLVQDFAALTILYFALPAFEYFGLFGYLVWNIFMGVFGFALFVVGHDCLHGSFSDNQNLNDFIGHIAFSPLFSPYFPWQKSHKLHHAFTNHIDKDHGHVWIQDKDWEAMPSWKRWFNPIPFSGWLKWFPVYTLFGFCDGSHFWPYSSLFVRNSERVQCVISGICCCVCAYIALTIAGSYSNWFWYYWVPLSFFGLMLVIVTYLQHVDDVAEVYEADEWSFVRGQTQTIDRYYGLGLDTTMHHITDGHVAHHFFNKIPHYHLIEATEGVKKVLEPLSDTQYGYKSQVNYDFFARFLWFNYKLDYLVHKTAGIMQFRTTLEEKAKAK
The following text describes a protein:
Function:
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
Sequence:
MEIDTLLEALKDFDKKVKKEASTVLDQFLCHIAKTGETLVSWSQFKTYFVFKLEKVMEDFHASAPEQRGPANPNVESIPFEEMKERILKIVNEYNGIPFTIQRLCELLTEPKRNYTGTEKFLRGVEKNVMVVSCIYPTSEKNGCSGVNRMNGVMLSGNTSAFTERKVNGPGTPRPLNRQKHSMSSSLATNGLPDSTENKDTNTPQGHSKTTSDASASGIGGPLGSSVKNKHLDDEEDEGMEEEEHEVKRLKFSQDGNEDEEDEDDVDEQVVETPRSTLSKSPSDKSEDPESPSSMLQEGSEEEEEESKHEGSAENSEDQEPSSTQPECPVADSRETFTEREVPCGSDDSSEEPSDMDQSEQRAPAGVASSPELREGEEPSEVSSSSTDDNASGPTSSSSSIDSPTEGDTGSGALDLESAEEPMEQD
The following text describes a protein:
Function:
Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes.
Sequence:
MSNNKIKRKDASPEQEAIESFTSLTKCDPKVSRKYLQRNHWNINYALNDYYDKEIGTFTDEVSTVAHPPVYPKELTQVFEHYINNNLFDIDSLVKFIEELGYNLEDLATLCLAHLLGYKKLEEPLKREDFLSTWFMQGCSTISDMQECIKTLDVKLHEDLQYFTQIYNYAFNLILDPNRKDIDTDEGIQYWKLFFQPEYPVRMEPDLLEAWFRFLRDEGKTTISKDTWRMLLLFFKRYPTIQKIISDYDETAAWPFIIDEFYECLQDQQ
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates.
Subcellular Localization:
Cytoplasm.
Domain:
The PUA domain plays a role in tRNA recognition through precisely recognizing the CCA end and the D-stem region of tRNA.
Sequence:
MSIFPKISLRPEVENYLKEGFMNKEIVTALGKQEAERKFETLLKHLSHPPSFTTVRVNTHLASVQHVKNLLLDELQKQFNGLSVPILQHPDLQDVLLIPVIGPRKNIKKQQCEAIVGAQCGNAVLRGAHVYAPGIVSASQFMKAGDVISVYSDIKGKCKKGAKEFDGTKVFLGNGISELSRKEIFSGLPELKGMGIRMTEPVYLSPSFDSVLPRYLFLQNLPSALVSHVLNPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKIFNKVEKIKQNALLLGLNSIRAFCFDGTKAVKLDMVEDTEGEPPFLPESFDRILLDAPCSGMGQRPNMACTWSVKEVASYQPLQRKLFTAAVQLLKPEGVLVYSTCTITLAENEEQVAWALTKFPCLQLQPQEPQIGGEGMRGAGLSCEQLKQLQRFDPSAVPLPDTDMDSLREARREDMLRLANKDSIGFFIAKFVKCKST
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein.
Sequence:
MNLTLNTPNEIVLNLTVNKVVAEGTHGSFCLLPRHVDFLAALVPGLLSWVDETGKESFAAVGNGILVKRANDVYVSAEAASHGTELEELRRLVREEFSQMDEQQRAAHTAVARLEADFLRRTMALTEDHVV
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MTIQETKKRKLDQNVLTCEYILPRKNRRCKMLRKKDAKYCSEHLIHDENFNGERIACPFSSSHTVWKKDLKQHMKKCNDRPKENTNSCYELDFNKSLNNAENFELANEEKEENTELMEKYIHVLQKIEFEPLEFRILHHEGLETRLQEKTNQKHPIQQNSIIANMDSMGLLSNSFLYLEFGAGKGELSRYLNQCILQQKTECSCTYGFGLIDRGKNRLKADSKIISDSETLQTKPQIKRSKIDIKDLNLDKFLVDLKIDKVVAISKHLCGAATDLTLKSILNSTLLSNDQFGGALIAMCCRHVCSLEQLLPQSRKYLHDHGFTTVQSFNVLKKLVSWAVDKKDAQENGILGLNTHQREEIGLKARRLIDESRVHALKSILNDKYKVEIFWYVQKDVTLENVCLSISRRTK
The following text describes a protein:
Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.
Subcellular Localization:
Nucleus.
Sequence:
CELPGGDVHLEKLGEGLGVRPLLCGSSLSLRTVNSSRSAYACFLFAPLFFQQYQAATPGQDLLRCKILMKSFLSVFRSLAMLEKTVEKCCISLNGRSSRLVVQLHCKFGVRKTHDLSFQDCESLQAVFDPASCPHMLRAPARVLGEAVLPFPPALAEVTLGIGRGRRVILRSYHEEEADSTAKAMVTEMCLGEEDFQQLQAQEGVAITFCLKEFRGLLSFAESANLNLSIHFDAPGRPAIFTIKDSLLDGHFVLATLSDTDSHSQDLGSPERHQPVPQLQAHSTPHPDDFANDDIDSYMIAMETTIGNEGSRVLPSISLSPGPQPPKSPGPHSEEEDEAEPSTVPGTPPPKKFRSLFFGSILAPVRSPQGPSPVLAEDSEGEG
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELIDELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIALQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGATVLALLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVESLLSAVGVDKLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIVRSSANVAAGARTRMSTILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNFVIYAITIVCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDGTLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVETSPAKLHHAHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHPHIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRSAESAGYPEADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEPADRPVDHESAQ
The following text describes a protein:
Function:
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
Subcellular Localization:
Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
Domain:
SH2 domain mediates interaction with RUFY1.
Sequence:
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
The following text describes a protein:
Function:
Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVNKPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFSAYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILCDMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIAAVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKETIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAESKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR
The following text describes a protein:
Function:
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
Sequence:
MVYRRRRSTQMQAATESVAVAPTAPVARPAKPRARMMRQYDLVERVRSYNPNTNEDLLNRAYVYAMKAHGSQTRASGDPYFSHPLEVAAILTDLKLDDATIVAALLHDTIEDTEATRAEIDQIFGPEIGALVEGLTKLKRLELVSREAKQAENLRKLLLAIADDVRVLLVKLADRLHNMRTLEFVPPESRRRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPEAYSVVMQRLDALAERNRNLIGEIEAQLSNNLRHRGLGARVYGRRKKPFSIWTKMERKSVGFEQLSDIFGFRVVVNDIEACYRALGIVHTTWPVVPGRFKDYISTPKQNDYRSIHTTVIGPGNQRAELQIRTEAMDQIAERGIAAHVFYKEGAGSPTEFLKRESNAFAWLRHTVGILSESANPEEFLEHTKLELFHDQVFCFTPKGKLIALPRHANVIDFAYAVHTDVGNSAVGCKINGKFSPLSSELQNGDEVEVLTSEAQSAPPSAWETLAVTGKARAAIRRATRTAVRDQYVGLGRRIVERLFERAKIEYADDKLKGALPRLARTSIEDVMAAVGRGEIKASHVARAMYPDYKEERVARYGIKKGLAAKLKEKVVSEPPRTPVAIPIRGINSDLPVKFAPNGGAVPGDRIVGIVTPGEGITIYPIQAPALKDFEEEPERWLDVRWDIEDTAPQRFPARIRVENVNEPGALAQIATVIAEHDGNIDNISMQRRSPDFTETTIDLEVYDLKHLSAILAQLRAKAVVARVERVNG
The following text describes a protein:
Function:
May play a role in keratin cytoskeleton disassembly.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Colocalizes with keratin filaments.
Sequence:
MARRSQSSSQGENPLDPNYLPPHYKEYYRIAIDALAENGPEAYEQFLMEEGAPDFLCPNEVEHISRSLQRPPESGQENPYPDSVYGSQEDADGSSGTYWPMDSDTAAPELDLGWPTIYGFQGTEVTTLMHPPPPDNPTIKEEVRRMIRSAQQVIGIVMDIFTDADILSELLDAANRRIPVYIILDQMNCQLFLDMAAKYRVNLNYVEFLRVRTVSGPTYFCRKGSTFKGNLQEKFLLVDCTMVLSGTYSFMWSFEKIHRSIAHIFQGELVSSFDEEFRILFAQSDPLIPSESALAKMDKSYMGMVPFAGPRPMFDRKLHFMFPREENPSQQFPSYGVDPDRHYFQPFRREDMIRQTMDPGGMRMYGKNLGDPMDKMQMSFVQNKQLEAMEAFKRHSFAEGTFENYTSSRQYSRQMFMNNNDEYRLQSSQVQKSQFMQFQSPLGTARPQGLFEKIRGGRQGLQEMDEFDSRYPTKGLPGEGHFALDGPPMRPGYNPSNSSREVRHGSDQMVIGGEGRFGQRSLGRQKFMCQISPTQKQGMEPKYFFHDQDADKKPQENKQGLRSWRISSYLSGIQSDQDEEGLPIPLDPELYDDALVPVERAVPASDTLFKYSMDPVPPYHPGTAPHDLPYDRANENPMKFSMDPVQLHRPNVPSQDVPMHLERAGNESLVKYSLDPIPPFKPNVAGTDVPMPLERKPTANEILSRYSVDPIPPYKTFGSTGDLSVEKAKENPPAEKEKEEGLLSRHDSFRTRTNPLIQRGSRLRSSLIFSSSKLEQHTSTAESVQEMQKEQSTSELVSENETGRTTSKVAEILQKYRGINKDANSTTVTQAKAASRTIHEESEDGQSVSAEEVAYKAVESTVDTKGSMSHVQQESQYRSVASSHLESLLGKHQTTLSMSKVEQMTSSIQTIGNISAAPSESGPTVPELSEVHKQSSISHMQQESHYKSVVTSKLEGLLNRDQQVMSMSKVEQTSSTIQTIGNISPAPPDSKESGPTITEVTEATQSSENLPTRPNSAFHFGSALESMSQNPTPSSSLNKSEEDLAKTDQNFFRKGSMRLKQFLQSKAEKKAEEDLASDNAKAEKQHSTLRRLSKSDSQEVAASTDMEEKSAKSLSVSPPKTSSISQSRLSASTSNVIFSSNLRDDTKVILEQISANSQKNRAEMVKQAQQIQATGDPDPATSKPESKTEGTASTDAAAITRTGSFLSRSRFSRPSPSSPEDRDILLKRMESIRKEKRVYSRFEVFCKKDEQPSHADDNDDKKAGKIIPKLLGNLIKK
The following text describes a protein:
Function:
Induces maturation and activation of human dendritic cells (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa-B signaling pathways, and enhances the ability of DCs to stimulate CD4(+) T cells. By activating DCs, could potentially contribute to the initiation of innate immune responses during tuberculosis infection and hence regulate the clinical course of tuberculosis. Involved in resistance to oxidative stress, via TLR2-dependent activation of the PI3K-ERK1/2-NF-kappa-B signaling pathway and expression of COX-2 and Bcl2. Also abolishes H(2)O(2)-triggered activation of p38 MAPK.
Miscellaneous:
MISCELLANEOUS: Could be an immunodominant antigen.
Subcellular Localization:
Secreted, cell wall. Cell surface.
Sequence:
MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAALAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIRTQQTAAPLANLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTLVSWDGIPVGPASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGHPYLSGLPIGLPSLIP