The following text describes a protein:
Function:
A bicistronic gene producing two proteins that are components of different complexes and have separate properties and functions. Full-length protein is proteolytically cleaved, producing a ~50kDa N-terminal product (Chiffon-A) that forms part of the DDK complex; it is unclear if the C-terminal proteolytic product is stable or functional (Probable). Alternative initiation from an internal ribosome entry site produces a C-terminal ~48kDa product (Chiffon-B or Isoform E) that forms part of the CHAT complex. Involved in regulation of gene expression during embryonic development; [Chiffon-A]: Regulatory component of the Dbf4-dependent kinase (DDK) complex. Required for the amplification stage, but not the preceding endoreplication stage of DNA replication in egg chamber follicle cells of the ovary. May be involved in initiation of DNA replication; activation of the chorion gene origins. May have a role in eye and thoracic bristle development. Required for female fertility; is not required for oogenesis but is required maternally for early embryo development; [Isoform E]: Component of the CHAT histone acetyltransferase complex, which predominantly acetylates histone H3. As part of the CHAT complex involved in acetylation of histone H3 on 'Lys-10' (H3K9ac), 'Lys-15' (H3K14ac) and 'Lys-19' (H3K18ac), but not 'Lys-25' (H3K24ac). May also regulate other histone acetyltransferase complexes. Essential for viability. Not required for early stages of embryonic development. May be involved in zygotic genome activation during embryogenesis.
Miscellaneous:
MISCELLANEOUS: Named after the phenotype of mutant embryos that possess a thin fragile eggshell resembling the chiffon fabric.
Subcellular Localization:
[Chiffon-A]: Nucleus; [Isoform E]: Nucleus.
Sequence:
MQPQSDKQSASRLATTTSHSTAAASATAATPPKVKVIKSKRPLCHFKFYLDICDHQLAKRIESDIKALGGHLEFFLSDDITHFVTDKPEVIGGTSGTPGTPSTPGTPTSHYQQNDGSARKPNQRQSRADAILSRVRRSTVGVVNSGNSTPTTSLKRSYTIWQTDYAQRFIKRIQTELKQYLEGKKEGGGGSTSASPHHIQLKKQYVKIESVKRNYRPYYHLIKQPDDWPKIDLSSEDGAFRLLTKSKTKDKEHSMTRKPLGSRTSQKDKQAAGEAKPLQHPSLQELKKQSAIPNSPRSNCREPIDSSEKQGGVCEICKLEYDILNIHLQSKDHELFAKNSDNFLALDTLIQSSADVNRFLEEEPVESELDMDVDESLSNEELQSPRQRPSPALREKSKRITKGKHSSEKFQGVAVASPQTPFPGAKKVQGNSPGSLSELQRQEHPTTAAATPTTNSGRRKTQNSGLSPPKRAMLPPSSIYKVVETREECATPPRGRGRPPNQVDSPSLIVKFQKIRQTELQRLNGEAENFMFPRTAVPTTRSSSELPTDVDRQTTSDVRGRYSISSASLDTSTSEAETKESSGLPTSIRKRAQAVGRRRKVGGAAAQDVFQRQLSTGSSSSNSNQQRFPSAPIQPEEGPQPQPKPQLKIKIKQEQLVATRKSSRTATAIVTAATASSHQQQQLRQTTCRKMANKLEDRMGELVKPKIKIKKEVIEEQKVKELEDLEEILDKELDEEVDSSCSSGSDEDYIAGSQRRITAAPRKSTDTREQRAARRLSRLTINRSAGELELTEVKTSPSKSRTKIQKPSSPTKNKVKQTKAVPPAIDLFFDCSKSERLREMQYTFESLPSGELWNRVFLRQDAGEENYYTYYGSTNYRKLPYEMGPIPMAKTLPAHSCALCREASEVKQDKGEQIKLEDQKPAPKKEVKKEEEVQSSSSSATYKNKKLHLLQRYQQEQEQLQQLEGNSLATAGAKCDSKASTPELLEREFASGSMGDRVQLIERVRSTSSSSCSNSQRSGITCRNKQLARIAELPPRKSPREHASTLALVSCIIRQRQDSQSKTNSEAEEPPPPVAAPKLKTPIKQEPVAPSSPRTTRSQAATPVEELRFATEISETVKRMRRGQNKYDHSPPAPVPTPATSSPVRSRRLTPAARNQSQIYSRRLEFATSQRESSASALLGKRKRRVNPSVAGTVRPTTQNLPGTGAYRGVRKLPSKKGLLEYEMETCALKALDQARQYCNPGFVAWQLDKYLELAGKEYDIEFDQISPEVESEGREERLVNTPQTPPPTDCFTSEFDLCDLIMGSAGSGDDDEDVSRGNPPGSGRRMSNLNLYASYYRKRKSLKSNRTGWPKAQRRRNAGGLGGSRALPDERINFQKMGLAELHPIKQEPMETEEEQTTTTTTTTTTSATRGNLLSKDDEDDEGGGNSPSGGSPADDKQNSREDAVMTPPATDVDEQAEPQADEMESLPDEDETMADSVDQQQDVEAEIEATDADVEEEEEEEDEDEDVFEDAYEEQDMGIQKTEPHEKRARIPSISVTTPPEDSSQGKKLLLTLHNGQRLQATSTPSTGQVQQHQRRTPQLNGSLGSCISPSEKLGDNSDIFTVSSDGLDTDLDLSNTQAGDSHEHCPHQTTPKRKFDISKYAPPNSGKAASSCAAEAATAAVKSLAISQFLKKETCASSSSMRNAWRRTQRRAISAACISAAPSARVPN