lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for correct embryo patterning and cotyledon organogenesis. May positively regulate the gibberellin signaling pathway leading to germination, hypocotyl elongation, and leaf expansion. Involved in the cytokinin signaling pathway that promotes shoot regeneration, probably through transcriptional activation of target genes such as CUC1. Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Miscellaneous:
MISCELLANEOUS: 'Dornroeschen' means 'Sleeping beauty' in German.
Subcellular Localization:
Nucleus.
Sequence:
MEEAIMRLEGAEHRETNIHSLKRKPSRTSSTAPGSPGGVTTAKAASGAGASGVSTIRYRGVRRRPWGRYAAEIRDPLSKERRWLGTFDTAEEAACAYDCAARAMRGLKARTNFVYPMPSLDSYHHRIFSSPPMNMFLLRDVLNSQSLSPLTTFAYPPCNLSNVNDVVHESFTNVNDVCEDLSPKAKRSSTIENESLISNIFEPEPASSGLLQEIVQGFLPKPISQHASIPPKSNQQSVGVFPTMPESGFQTDVRLADFHVEGNGFGQVKYHGELGWADHENGFDSAKMQQNGNGGMFYQYCFHDDY
The following text describes a protein:
Function:
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Subcellular Localization:
Nucleus. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci.
Sequence:
MVAGMLGLRKEKSEDQDLQGLKEKPLKFKKVKKDKKEDKEGKHEPLQPSAHHSAEPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPGKLLVKMPFQASPGGKGEGGGATTSAQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHAESPKAPMPLLPPPPPPEPQSSEDPISPPEPQDLSSSICKEEKMPRAGSLESDGCPKEPAKTQPMVAAAATTTTTTTTTVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRYSLQARSALRGVRFSSSHSAPKPGSTIPFYINKKPLPTLLYFGTFGVIFSIPFIVVKYHNRNL
The following text describes a protein:
Function:
[CLE18 C-terminus]: Root growth factor that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells; [CLE18p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Root growth factor that regulates the pattern of root growth and lateral root development. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular Localization:
[CLE18p]: Secreted, extracellular space; [CLE18 C-terminus]: Secreted.
Sequence:
MHLLKGGVVLIITLILFLITSSIVAIREDPSLIGVDRQIPTGPDPLHNPPQPSPKHHHWIGVEENNIDRSWNYVDYESHHAHSPIHNSPEPAPLYRHLIGV
The following text describes a protein:
Function:
Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADHAVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRARGTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHTDQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPKPRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRRRSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRYRIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRPLLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHHVSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPDFARRGACPRGAQCQLLHRTQKRHSRRAATSPAPGPSDATARSRVSASHGPRKPSASQRPTRQTPSSAALTAAAVAAPPHCPGGSASPSSSKASSSSSSSSSPPASLDHEAPSLQEAALAAACSNRLCKLPSFISLQSSPSPGAQPRVRAPRAPLTKDSGKPLHIKPRL
The following text describes a protein:
Function:
As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLELLCRVSPARLPWRSCMSLAIQPAQRRRFATEAAGKRTETEKSAFTEWRTVYSMPGIRLVAALSRLKVYQAVITAAGTPIVFALGSAGQLSTDALAIYAAIGVTGLITLTLASYASSNLVGFIYVNEEQDLLKLAYVDFWGRRQETLIETEDLLPSWEQGSPSRLRFVSPICLRSDSKRRYKLLNRFGHVSDRQLFEGLFGN
The following text describes a protein:
Function:
Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPHRWLPLEANPDVTNQFLKQLGIHPDWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYETFRTEEEERIKAKGQDVKSSVYFMKQTINNACGTIGLIHAIANNREKMNFETNSSLKKFLEDSLSMTPEERAKYLETYEAIRVTHESSAHEGQTESSSSSLSSPPSSSQPQVSHSRTKASQLCQSASLSWAKRNHVGPAKATSPSIRLRRWRPLIRLPSVGLHSVAPSIDEKVDLHFIALVNVGGHLYELDGRKPFPINHGETSDDSFLEDAIEVCKKFMERDPEELRFNAIALSAA
The following text describes a protein:
Function:
DNA-binding protein that plays a critical role in nucleoid compaction, genome replication and DNA replication and transcription. Binds to both ssDNA and dsDNA with a binding site covering about 15 nucleotides. Displays DNA-supercoiling activity only when associated with the viral DNA topoisomerase 2.
Subcellular Localization:
Virion.
Sequence:
MNVSVERYQRRKYVSQENSPMLYYVRQKSGTVRVMDVEKLADAIEANSSLTAGDVKHAIEAFVEQLRLSLTQGDKVKIDGLGTFHITLCSEGTEKEKDCTVRSIRKVNVRFVADKALHLVNASHTSTRSENNVEFVLASKGDTEGGNAGGGNTGGGGNSGGGGNSGGDEEAPDPTV
The following text describes a protein:
Function:
Involved in the biosynthesis of sulfolipids found in thylakoid membranes. Converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAHLLSASCPSVISLSSSSSKNSVKPFVSGQTFFNAQLLSRSSLKGLLFQEKKPRKSCVFRATAVPITQQAPPETSTNNSSSKPKRVMVIGGDGYCGWATALHLSKKNYEVCIVDNLVRRLFDHQLGLESLTPIASIHDRISRWKALTGKSIELYVGDICDFEFLAESFKSFEPDSVVHFGEQRSAPYSMIDRSRAVYTQHNNVIGTLNVLFAIKEFGEECHLVKLGTMGEYGTPNIDIEEGYITITHNGRTDTLPYPKQASSFYHLSKVHDSHNIAFTCKAWGIRATDLNQGVVYGVKTDETEMHEELRNRLDYDAVFGTALNRFCVQAAVGHPLTVYGKGGQTRGYLDIRDTVQCVEIAIANPAKAGEFRVFNQFTEQFSVNELASLVTKAGSKLGLDVKKMTVPNPRVEAEEHYYNAKHTKLMELGLEPHYLSDSLLDSLLNFAVQFKDRVDTKQIMPSVSWKKIGVKTKSMTT
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis (By similarity). Essential for flagellogenesis during spermatogenesis.
Subcellular Localization:
Cell projection, cilium. Cytoplasmic vesicle. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=In male germ cells, strongly expressed in the vesicles of spermatocytes and round spermatids and also in the acrosome and centrosome regions of elongating spermatids and in developing sperm tails.
Sequence:
MASNHKSSAPRPISRGGIGLTGRPPSGIRPPSGNVRVATAMPPTTARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLRSKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKLNTNTEMEEVMSDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGIIKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNMKKESLETEIAHSQVKQEAVLLYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKINQFSEEIRQLDMDLEEHQGEMNQKYKELKKREENMDAFIETFEETKNQELERKAQIEASIITLLEHCSRNINRMKQISSITNQELKMMQDDLSFKSTEMQKSQTTARNLTSDSQRLQLDLQKMELLESKMTEEQQSLKNKIKQMTADLETYSDLAALKSSAEEKKKKLHQERTVLSTHRNAFKKIMEKLTSDYDTLKRQLQDNETHAQLTNLERKWQHLEQNNFVMKEFIATKSQESDYQPVIKNVMKQIAEYNKTIMDALHNASRS
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKVILKTITGKQHEVDVEATSTILDVKRLLEDEYEPASLRLCFNGAVLEDSMMLADAGVKDNDSLVLAGRKRKIPKPPAPQTAETPTTEAAPESSAPASSTPPPAMSAPALTTTSPATSAAPVDPPAPAVPTAAAAPVTSTTPAGPAVPAAPAASTTNTYGVAPNLIDEVASMGFEDRSQIALALRAAFMNVERAVEYLFEGIPSHLVEELAPFSAPAAPAAAPGASNPSASSATAVAPASASPAPAATPSSAESEMRAALSRIPQFDEIRILYNQNTDTLPVVMQQIALRHPAVYEQIERDPEVFLSIMSESGQPGTASAPAGSAAPSTAQAVAGDAEESSFMNQLQSGLELTAEDRTAVQQLVELGGGMWDEQSAALVYLATQRNQEVAASVLFEHGGVPAELLAEIATQMVDEEAEDYEDEQ
The following text describes a protein:
Function:
Extracellular signaling peptide that represses, in a dose-dependent manner, primary root growth rate and lateral root elongation by inhibiting both cell division in meristems and cell growth in elongation zones. Also slightly prevents growth of above-ground parts. Regulates systemic nitrogen (N)-demand signaling. Mediates systemic up-regulation of genes involved in N uptake and assimilation pathways (e.g. NRT1.1, NRT2.1 and NRT3.1).
Subcellular Localization:
[C-terminally encoded peptide 1]: Secreted, extracellular space, apoplast. Note=Accumulates in xylem sap under nitrogen (N)-starved conditions.
Sequence:
MGMSNRSVSTSIFFLALVVLHGIQDTEERHLKTTSLEIEGIYKKTEAEHPSIVVTYTRRGVLQKEVIAHPTDFRPTNPGNSPGVGHSNGRH
The following text describes a protein:
Function:
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Subcellular Localization:
Cell membrane. Membrane; Single-pass type I membrane protein.
Sequence:
MSAGARRGPRGSRAQPLAPLWCFSAALGMLWSPASQAFNLDVDKFTVYSGPEGSYFGYAVDFHIPTARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSVQCKQIPFDNTNNRKIKVNGTKEPIEFKSNQWFGATVKAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEYSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITASIADIIANYSFKDILRKLAREKQTEVAPASYDDSYLGYSVAAGEFTADSQQELVAGVPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVAVSDVNNDGMDDVLIGAPLFMEREFESNPKEVGQVYLYLQVSALVFRDPQVLTGTEVFGRFGSAVAHLGDLNQDGYNDIAIGAPFAGKDQRGKVLIYNGNKDGLNTKPSQILQGVWASQAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEATTSVACFSLRVCASAAGQSISNTIGLTVEVQLDSLKQKGAVKRTLFLANHQPHLVFPLVIKRQNSFQCRDFVVYLRDETEFRDKLSPINISLNYSLDDSTFKDGLEVKPILDHYRENVVTEQAHILVDCGEDNMCIPDLKLSARPDKHQVIIGDENHLMLTINARNEGEGAYEAELFVIIPEEADYVGIERSHKGLRPLSCEYKMENVTRMVVCDLGNPMVAGTNYSLGLRFTVPRLEKTNVSINFDLQIKSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPRKEEGVGPLVEHIYELHNIGPSSISDTLLEVGWPFSARDEFLLYIFHIQTLGPLRCQTNPDINPQDIKPAAPAEDTPELSAFLRNSTIPHLVRKRDVPGPELHRQSPAKILNCTNIECLQISCAVGRLDGGESAVVKVRSRLWAKTFLQRKNDPYSLASLVSFEVKKMPYRDQPAKLPEGSMAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDDMNDREQLTNEKTPDA
The following text describes a protein:
Function:
Probable component of the NALCN channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MITGAWRCGRKLDAELEICRVTEPIDKPCAESEKVQRWRMSLASLLFFTALLSDHLWLCAGGKLRSRDRTHRRTWNNASHDAQTGLRDEDCGVLLSNLTENGPDCVEADARRRAPLESACSTLYRQKSGSVSSSYSVTVPTVSPHAFLEYFRNFSLSFCDALTIADLLESMTSPDGLNCSLTHIIRDLFSGGPEDGDACSACVHAYTRLDQHAQEKYEEFDALTRKYMADDYSVRAQTHLCQVVYKAWLCAEYFPVPQRQCVRWLPCRHYCGEVTATCPFILPDNDRLLYAGSPSFLCAGFQEEYLSSQGPDCCDVRWSGCDSAVGAACALTHLPGSFSFHRRLSSGAMSCTNRLHGSKLKLCVLVLFLLHTFISITTLQHCSTGSLEAIVPLEEVPMREE
The following text describes a protein:
Function:
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.
Subcellular Localization:
Secreted.
Sequence:
MKNHLLFWGVLAVFIKAVHVKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTPDACYPD
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Single-pass type I membrane protein.
Sequence:
VLYSIHGNGVDQDPLNVFIVNPYTGFIKVTDTLDREKIAMYNLTGIAKDTNGEILEKEIKLRIAVIDKNDCSPVFEEDKYAEVYELSETVILGTPVVRMTATDDDDPATDHTKIKYSIVSQSPPEPQIFSMNETTGMISVIKPYLDREQQSTYTLIVKGTDMDGKENGNTGTGTVHITVLDVNDHLPKLEKDEYSGSVDENTENVEVMRIKALDEDLEFSDNWMAEYDIVSGNEGGYFSFTTDTETNEGILMLNKALDYEVIQNLELSVAVRNKVVIHSRAAASFSSGTKTYPLKIHVKNQPEGPRFIPKVKAVSISEETKKVKLKSVITKYLAVNSDTGMTAERVRYAKAFDPDNWLSIDENTAEIKLNKLPDRESKFLVNGTYYAKVMVMTNDLPAKSATGTIALQVEDSNDHCPVLTSTSQVLCTESTAVFVTAEDEDADPNGPPFEFEIIPEGTKGTWIVEPLNDTTAILRTHDNLWPGSYEVAVEVKDQQGLSCPDKQVVKIDVCTCNEQKTCEATRKTTGAGLGFAAMGLLILGFLMLLCKTSKCYMITPKKRFKKFRPFDTKEHLIAYHTEGQGEDKILKLSVTILRCVFLTQEIPLLSAPLEIVPGRFYFGKEEWDFMSIWHDNIHVKTGNMCQEEMLKQIRSGTTYSIHEDSYVDIALSERYLKSRYITEPDTEPEALVFNFEGRESPVGSVGCCSFIEGDDDLEFLNDLGPKFKTLAEICTSK
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MEIIVGEIPKKINILDIIAIKESEVEEELVCSICANIMIDPTSSLLCSSHVFCKACLVKWLEKSQSCPTCRCEVPKDTEYALVLKVEFEDKINNIKVHCPYAFKDDSFEEIDHDHGCKEIITVSKFRQHINQCIYQFKKICGMMRLYEMHNHYEKECPYVILECIYCSKQYRRGNTESHLKKCQKVLVECGNGCIEKFARSEIEQHSKDCPNRIVECQFKDFGCTDTFKFGQYKEHSSLYDNHRDFLFKKVEVLSLQVCSLNNQIMTFKETIDEQNSQISQLRNLVLKRKVLFFHQSLLEKVIKRKSISVSYSSKDHAFDKNKRYYYMHLNKESLDEYSNFDMVITIGDKIILDVKDQCFSIRKEISYEFEFNSVDNSFLQGNNVIKTFYLHLTA
The following text describes a protein:
Function:
Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.
Miscellaneous:
MISCELLANEOUS: Is not inhibited by EDTA which points to a metal-independent mode of action.
Subcellular Localization:
Cytoplasm.
Sequence:
MELYLDTSDVVAVKALSRIFPLAGVTTNPSIIAAGKKPLDVVLPQLHEAMGGQGRLFAQVMATTAEGMVNDALKLRSIIADIVVKVPVTAEGLAAIKMLKAEGIPTLGTAVYGAAQGLLSALAGAEYVAPYVNRIDAQGGSGIQTVTDLHQLLKMHAPQAKVLAASFKTPRQALDCLLAGCESITLPLDVAQQMISYPAVDAAVAKFEQDWQGAFGRTSI
The following text describes a protein:
Function:
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
Subcellular Localization:
Cytoplasm. Postsynaptic density. Synapse. Cell projection, dendritic spine. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. The N-terminal of isoform 2 may facilitate trafficking of the complex with GRM5 from the endoplasmic reticulum (ER) to the plasma membrane (PM).
Domain:
The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. The coiled-Coil domain forms an antiparallel tetrameric arrangement (By similarity).
Sequence:
MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFPHSAGDRTQALSHASSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELNQTVQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRSNLKTLLEILDGKIFELTELRDNLAKLLECS
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRSRFRGRITGWYLMASSSGEKLDWCGCGRPPRIVVLGAPDKLNVSSAWKRLRPTIQSHAELIAADFEFTYDFSDKEVDLVIVIGGDGSILQSARQMGENQTPVLGINCGRLGFLAALSPEDFLDAWPKVCQGDFSIIRHLMLEVQLIRDDEVIAQSMALNEAAILNGPPFAILDIDLYADGELATQYRCDGLIVATPVGSTAHNLSAGGPILRRQLQAIVISPISPHTLTYRPLVDSADTRLELAVTEPNESTSIVVDGRILGQLKSGDRVRVHRAPVSFEMLRVPGQNDYRTLREKLGWSGRLALRQL
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MALLGKTLKGRTTKPGGTEQKRNIKIRQITKSQQEFEESQKQAQFKKEQLRSKIREEQKIVNFNTKKLMAYWRRTMRAVKTEQLKQDIELYSQNNKRELDSKEAFIQMLDKNLDEAEDQYQIALRNHLIHLENFHLLQESRNRALLEEFERDIKILQEEFQIEFDDMTKTHKQQVKELEDMIKTVEEEEKRKAELAKNQHQTNREETKNKDVEDTSQMKQQLEDKQTKFYNDLEQMHQKYQSDTAKKTEDHTKYYDANKDMSKKIERLVRSIASKKAKIDLTKYKILQHTKECNARNQALKKEKENIAKNYQDLKQKMNKFREEQQRLLKELVNNSRNAVLKLTEYKELGEKILKTAELCRRLETEREKVLPFYEDTVDMDQIPENLKNDFEAIQKEEYEEFAYLNNFYKRYNKVLLDILAIQKQKEALQNESNQLQSLLKQYLDGLSCNDDVLSNPNPLFVKNFNIDLGEKQVTGDLQQTVIEGVFNVRSTQMQLQGQRVGPFQ
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein.
Sequence:
MTALTLLAAPGIPAGWEWANPLIDLLPIIPLLFFALAFVWQAAIGFK
The following text describes a protein:
Function:
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Subcellular Localization:
Secreted.
Sequence:
MSKVPLLLCVALTLAVLAGGAPTSPPPTSLLEYLLLDLQEAHEKLSGVSERMKRYELYVPSRARSIADLQCFTKELHPVADALKYESREARYIQDHIRNINVTVNRLMGTATTHCQYAVKIKIRGFFGEWITFCQRLIHLTR