The following text describes a protein:
Function:
Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis.
Subcellular Localization:
Cytoplasm. Lysosome.
Domain:
The UBA domain binds to 'Lys-63'-linked polyubiquitin chains, but neither to linear nor 'Lys-48'-linked polyubiquitin chains. Required for mitochondrial size regulation and for mitochondrial clearance in the intestine.
Sequence:
MLRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDALRSFNLPVEVTAGSIRKIKLQIPVRQFRTSPWCISIEGLFCIICPKNLDNWDYEKEKLQDLEYKLAVLDTAEAGWRSEKGKQMESYYFSSYNNWLKYGTNMATNIIDNIELKISDVHFRFEDIVDTGKSKICTGIKIGSLTAQSCDCDWTNGSYKMNNNEMNYKLVELKELSVYWDLLHEDIKCQSYSNQEILEKMHSTCELRSHNFIIKPICATARWKRDKCQQVIRTKDKPRVSCELLVPEVVIDISKVQRLQMLDKLSEIRQVKEVRQYRLKRPTCTVESNPIAWWKYATICHGFDFKKNEEKWLMLKENLRYMLLYKSIILNPNENLSAADKEFKAYIESDRKISDLTIMRRICFEKVFTKGFAFESQNEQGKNMLFHWFPNWMGWYANSPSTPNNEQDESLKHLEDDILVALENSLQNSSDLKSDAVFGHFSIKLLKGLVILQTEDKLNDGRNKSMEMQFNNFSAYLQLSPQLTSYTVGISLQEVYLIDKTSSDTMHNYLIKPQTGNTATPNQLVKNAALQEDILFQLQYENCNHLRFQLNIKSKGLDLIYNEDAIQWLLDFLADSNSFKYSPRNRVAKKTDFMKNWNEMFSGNEVNRKIWMFEIEIFAPRIIFLENYKVSNSLMVLLDFGKLEMRKMEVKRVIPVIESAVTENTSDDDETYLTPCSTPPASEKSGSESPTLLENPKTESFLNKNVQLEYVLHNKIYDKYLINFTNLQVLVCKYEERWQACLKTSSNFHLIDKFNINLTLEQRNIFTVDPEYPSFMLFGTCPTILIHGNEELINNCCNIMKPIIKASKEMENIYRGGNTIYASERIKNLAEDDRSRVVIEFVMDQLVIEMQSTERSIAELQIIGARAGLTKEPHETNISMSVHGLLLVDAIQSFGPDFELLVASHRHVGMDSLSGSLKHSAIVSPTSPGSPNFFDRATSPHMITKAVQNIKMGDRSTEFCDDEDSTALISVDIKIVPPNESNSMQLHTTSITFNSLDIIANQDTIIEILNFAKRTLLAQNIFPSESPESPKEATEAPVDVVDQVDHKSHNEIFFDFFRLNILLLYTIKRDKFNVGRKVGTVTLTEAKINASFQSDLSIIGSLGGIQVIDITSEAFCHPRILSVGRDQILRASDTNKQTVLSQLSNEIYSNNYNEETKSDESDAISFQSHWSDKTTCTFQMRMASASYTHCPRFLRDVNACITYFKRSLREFATSIGNKATDMAKEFVQQVRAVEQIGPVYPQRNRQDNWLDIIISSPIIILPISNTSTNVLIANLGKISCSNAVKCDSDEFNESYTIEIKNTYVYSLNIDEGEYSFNVHPAKNKDAIPILHDTAITLQLYAGYSDDNDEDKQLNRFSIKGSMVEALKVSLNRKQYELLLESIRYATNFSNEVLNESDELDQNGDIEPTANIDAESIISTTIQFSVPVFQINLQNEYHNDLINLTFKNFNVKHISKGFDKDVEVVLKSVLMEDLKSDLTSPFRNMVTSVDLEQKIKKNEMTSSSCPDLPSYCNSLKNRSSSVPSCFYNHMQVKVFGGDQKYTSSNKNELGKKKESQTLVIYKSHTGRSAQNGKLEQTSSIQFNCLNLAICVERWYTIFDFFGLVSVDNVNEKYPEEMKLVEKHIDKVCSKLKVSIRSFNFTLIRNESLLSRVNVSNAVFMILQDPYSKIVEGCLGSVSVNDLTKYGNIYKQKFLTSGTEALNFVYKKKLVDLEALNTLDTDSTLRINMSAVHYIHTKRFSTELHVFVKDLLQLQTPVIRKLKKHGSEQNMRPSKMKLVIQADSPVIVLPSSYNRNEVIIAYLGQFSLKNSFHFASDNNIISKMSATPSKDEILDVMRIDLVNINLFSGERSSMKAKADQEKDRIIIADMNFLRLGQPFFNESCFLHLQLERNLSADAHRVCPDISVQGTFSKLSGIINIQQYKLIRSFLNNNIGEQTDDIYMNYHNNSCTSIERLSTINLMPKNEVSKIVSILISIRILLEDVSLLLALNTSQSAAIEPLACIHFLKSTLEIDLFSDGSQDIDLISSNILIVDERNESDKSNENVFKNILEPSKKEVRIENSVQVEVHCRKKATFSKYTIMLNNMRVFALLSFLDQLKSYLQEDSPAPVVNNAANQIAQKPQIDTSISTEYVVNITDSEIIFAEECSRLDSNAIILKSTTVICYKPNSNIVPLSLDINHLEIFSCTLDAEEESALSIIDPFTLIIELRSNCLNILIQKHLNIRLSYVDVKLFSRMARLLPTQTSRPKNVISKADSDLEKAAPLVAMGFEISDCLYAMQINNWRINDAAIWLSQQKQNTYRNPALEMKTAVVDASLISVFIIDDCMDADVPLLEVSLSKFLLNFTFQTQDPNPKETNIRHYSLGNIDTEVSVNYYNRRLSGWEPVAETWESNLNWKYTKGHLDNKKRFEIGISSKQMLKLNVTSTFIELFHMVLKNWTNDFNDNGAKNFRQRSPFIPFALQNLSGTPLLFKPIYAPLGDLTRSDLQQVELIKNWYSVQPNETKTFDFSQKSKLRHVHSHQLNLHQIFVQIHGWTLIGPISVDKVGMFFRTTKLDSQFLTKSRIVFDISLIGSAQKLIKVKSSLGVINKLDRNVFLKMTLKGTHSDGLSSISVIKPNDELSVPLKFIDASLYVAHNTSESDAYEDTGFSNEEILWKACGKDDTRQLLAGYDTNKSILYTFVNISREIYHCKEQNLPGHKITLLPPLKINNMLCCDLMFKIHEHATGRINSSESVNIYNVNICQPLNLSITLDNFQLSGQLKIPVSHRGVIEPKLKLIDIQKRELHVRVSIQSVPGKGMELYISAPVWIINKTGLPLIYKQEGTSHTAAGQFEEHETARQVAPLMFSFSDQEGSPALVLRLGKAYGSNNMWCKSFSTHKDLADRDLRAENTKGSYAIGISVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYDRPDPRKIISAPVDCNFAFHWPNWDQEQIICVRIPEIECCCWSKGIPIKDVQSLYINVRNEWGEMFFLRLEIISKDATFILLFTDARTLPPPIRIDNCSEVVINFSQLRSKPVWITPVRPQSSLSYVMDDPLGQQILLMEAPGGNMIEFPINNKNNIKKTLTYTNFIYIAFQGTFERSNEEENTHRQLVLGVRGKKVVIVEKNSGDRSQLWLMNSNGQLEHEGSTPPIQTNDANAVRLVLDLEKAPNPMEFTNLVVRTPNKQRVTTQTWRFENGRLMCHANMCVQSRFGESGLKPNYEAVVGRTENRASSSKQIPIGQHIVAQKLRPGSGQLELSTKMDGPISTIEICDIKIKQNSVFLTPDLLWMHASLNNRQITDKGKVSFVHEYLINVELVKGIGISIIARKPCEEIMFISLDHINCDIVQSALENSLDLNIAYIQIDNQLLDAVSPIALHTQTSNDLEETQNAVVLKLKMLPSPNKNAIIFKYLTLDLKPSTASLEEKLILKVASFLGYGKINRQNLSVQYQFENTDDKPFLQDMKRYYFENLSIGATQVRLSAFTSSKLPVELHETKKALGLTLIKFEDALIELDRYSDKLHFETMDVYRKELKKHYINQVKWHAAAILGSVDFLGNPLGFANDLSEGVSGLIFEGSVKSLVKNVTHGISNSTAKLTETLSDSLGKVVLDDHDNETRQRILELQSNTSGGHLAAGLKGLGFGLLGGVTSIVRHTYDGATSDGVPGFLSGLGKGLVGTVTKPIIGVLDLASETASAVRETSRDSHRNAPERKRLPRCVTGAPGGLLPLYSNRQSKGQQYLYLINQKNFSEKIISYEPNLWSDKEARLRLLVSTEYVRIFSLSDANPTIMFECHVSEILSCHPVVTNAGTTPTTSSRASASHYIEISTNLPKITRPRIRCRSEECAEAASRCINYAKSVFDEREHAVL