lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MFSPQTVLVTPQHGEMAEQGSGRSLGSYSPVDYMSITSFPRLPEEETGGEPGPRAGEEDTFLGEHDSDPDAFLKSARLQRLPSSSSEMGSQDASPLRETVKDPFTSDCSCRQDSLTVIITACVTFAIGVTIALVMQIYFGDPQIFHQGAVVSDASRCTALGIDVLEKRGSSVDAAIVTALCLGIVNPHTSGIGGGGVMLIHDIRNNVSNVIDFRETAPFAIHEELVRRYWKERPGILVGVPGMLKGFSKAHEMYGKLSWQEVISMAAEVAHGGFNVTHDLAKAINESRGQTFSNAFLETFLPDDKPLMAETFIRRPDLAAILYAVAKEGVEAFYSSNLTQEMVSEVNAYGGVMAEEDFSNYSVLVEKPMQTVYQGHLVFVPPAPNAGLALITALNILDGANLTKQTPRASALHWIAETLKIALATASTLGDPTHDPSMPGFVKEMLRESEINFLRQRINDSHAAPTEHYMPFYNLESGSASSQALVVGPDDFIVAVVSSLNRPFGSGIMTSSGILLNSQILDFFWSNRSNRTSFPSPSNTVEPGKRPLSFLLPTVVRPAHGLCGTYLSLGGSNGDRALTGITQVLLNVLSFNKNLSDSVSNGRLHPDLQTSLLEVDGDFPENDTLGLESKGHLLRKIPILGLVHGSRRSNDLIIGIKDPRSKDAGASTIL
The following text describes a protein:
Function:
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
Subcellular Localization:
Lysosome.
Sequence:
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
The following text describes a protein:
Function:
Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Inner membrane-associated and cytoplasmic. Colocalizes with the structural transitions in the microfilament network during cellularization.
Sequence:
MEQLLAQLHTCSELIAEGYSSTGNIGWLNEFCATFLDFASDLKARLPEVAPSGANLDVETIFLCLTQVVTCITHLERTISMEAPHMTRQHFLDRLDWCLRRLLVSLTQLEGNVTPVKNLEDHSFVELMDLALDHLDDYMEKLAQQRNNSLHILEESFTEDTYQLASIVNHIVRHALAFANVAIHSDKKALTALCETLLAECATFHEEAGEPNSGHRKLEALSLERALYALESFLNEALLHLLFVSLIDLENASVEKLKDALQRDPAGAQELISAFDTNMDRIQQIGVLAIAFSQDIKTKTIVRSCLASLESLDACIVPALQLPESTSSAHHAEVLQEHFNQELLIFRNVIHEIIDSCSLINNYLDMLGERIHVQDKSHLKLIVQRGGVVVDHFRLPVNYSGLSEDGKRVHKDLILILRECQAVVNLDVPVDPKRIVKRLKILYSVLAKLRDLICRDNLEPDSSVASEAQVPSSATRTFVRSSRSFGKRHRSFVKQTGNCSVFGPQDSLAESGHSESDLISFQITEILRLD
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Mitochondrion. Nucleus. Chromosome.
Sequence:
MPLQKSFSETNHSGKENNSRPQWQRNKNYESPQQKQKPKVPAKPLAEKPPIPVSTTTKNILNNFQYREQTGKKDDAKEVINLVSSEADSRTATPSKKRRQSSSKDGKTSVEEDVSLEEPADAPSTPSMGFDPTQNTDFKRPFKAISPDDRIIWDTNKDSQQLPDPRTSNLGKRKRGDVEFHRAQSSSPILGRSSQADSRPRPGPEVEVWMRVTQKDHKLSRIMDNASPQSLKDGNALRGLTRSRSLGNPLNPKRHQPNRIGKNRDIDTPGLMRRLQEDYKPKDFSSGPSSSSPLPNKGLFHEGLSSPLGQKGTERRTSPLKRRLEPPSSPIRNADSAAPLLSPKRPSTSESDYGSDDGLDEIGGMILSAIESQSQAPPASKSRPLPPLKKHQPPTKPKTYSTHKPPNVSRIPTTSKVVDDDSSDEFGEGLDDDDFDAAFAGSVPVDNVELPPSRPRGAAAKEESDDEFGDNIDDSDFTAAEIAATQSLKPSANSLMPSMEKVRAIQRYLVTMIDNNQYEGVNGRLQPEKILFLQPERSKVKRMVHLRGTWIDTPVTMKAFVHIIGKFDSQGICIIDDNSGLIILHPDHLISALVVADSFGCTRRAVLQDRVKATGEASPAMLYGTILHEIFQAAMLANRWDTRFLGELIDKLAQRHLEDLYVIKVEIPQAVEYLHSKMGELQAWAELFVSSQPKPEALVKASNGDSVAMCVSNLLDVEEHVWSPMYGLKGNIDATVQITMRDEKGERTLTAPLEVKTGKNPSIANRAQTALYNLLISDRYDVEIAYGILYYMETSETIRIPAIRHELRHMIMQRNELACFVREKNAQLPPMLKKENMCGRCYAKNTCFIYHKLADDGNGETSGMKEKFDEVVKHLTPKHKEFFLKWDDLLTKEEKDSLKFRRELWTMLSSEREKLGRCFSNVVIEEGSAYEDLNNEKINRYRYTMIKPKNSTTPGFSFMDSQIIVGEPIVISDEKGHFALAKGYVTNVRKNRITVAVDRRLHNARIRQPGFDETNNQVFASIMEVAAEGSTPADSIGKIKEDPILYRLDKDEFSNGLATVRNNLIQIMTEGPFGSREIRGLVVDLNAPRFKPHSTQYTLKDRSSINVDQRRAIEKVMSAQDYALVLGMPGTGKTTTIAHIIRALVSQGKSVLLTSYTHTAVDNILLKLRDDSIPILRLGAKAKIHPDVQEFAKLAIDPKETMEEIRSVWHGTPIIATSCLGINHPIFNERTFDYCIVDEASQITLPVCVGPIRLARTFILVGDHNQLPPLVKDEEARKGGLDISLFKYLSDAHPQSVVYLEHQYRMNADVMALSNTLIYNGRLKCGSESVATRKIIIPEMDALKAHHHTPSSILHSTQKSICLEPKKGRCWLRDLLDPDVTVAFVDTDGLGEIARESEKGNRTVNDVEAKIVTQLVTSLISVGVDPTEIGVMTHYRSQLALLKDSLRTAKGVEMHTADRFQGRDKEVTILSLVRSNEAGNIGELLKDWRRINVAFTRAKTKLLVVGSRGTLKGSSERREVQGEKKEEMVFLGAFLGGGRWFDAGECGSGEFVAVGWGGG
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAKPMTAAAAIMASNANRQSAPSPTPAPATKTQANQASQLTELEPELPVESLKVDSLAVMKIIKHAREVALSSATSPASGQLLGIDSAGVLNVSDAFPLPSGSLGSNAEGEDKQASQKSTARYTASILPRLSALGADANVVGFYCSTVNGQHCATPGFIETLISMQIGAPPAANPKTKTVTSVRSKIAGGKGVALVYDLASATEGTVHLKAYRLSKEFIETYKSGKFDSQNLANHKLTTSNFLQEIPLNIQSSALLTAFLATLIAPSKTGGQSGSVSNGSWGQTSTGSTCKLVDFLPSYSPLGTPSSSCADSPLSLSESLAATIASIDTHNTALSTLSFQIRQLARDRARLESVINKRKAENETRAQQGLPPLPPSAEEASLKEPSRLESMCALSGVDSAAKKLTESSGLNVVRAFGAKAGVAN
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.
Subcellular Localization:
Lipid droplet; [Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain; [Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MCQGYLRKAPWSTGKWLQFPQLALRRRLGQLSCMSRSTLKLRSWPLSFLYYFLPFGALKPLAKVGWRPTSRVALYKSIPTRLLSRAWGRLNQVELPTWLRKPVYSLYIWTFGVDMKEAAVEDLHHYRNLSEFFRRKLKPQARPVCDSHCVISPSDGKILHFGRVKNCEVEQVKGVTYSLETFLGPHTWGDGLPPNRNEEDSSSFQDVLVTKEGNQLYHCVIYLAPGDYHCFHSPTDWRVAHRRHFPGSLMSVNPGVARWIKELFCHNERVVLSGEWTHGFFSLTAVGATNVGSIRIYFDKDLHTNSPRYSKGSFNDFSYVSNNNREGVYMRKGEHLGEFNLGSTIVLLFEAPKDFTFSLKAGQKIRFGEALGTM
The following text describes a protein:
Function:
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity).
Subcellular Localization:
Nucleus speckle. Note=Nuclear, in a punctate manner.
Domain:
The C-terminal domain is required for transcriptional activation.
Sequence:
MGDTAPPQAPTGGLGGAPGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATASTATATAPPPAPAAPPTASQTAAPAAPAPPPDYHHHHQQHLRSSSSSGGSGGIDGEQQQQPPASTPGDQRNSALIALQGSLKRKQIVNLSPANSKRPNGFVDNSFLDIKRIRVGENLAAGPGGLPVNNGQSQMMSGTLPMSQVPLRKTAALPPPPTHSPGNGLFNMGLKEVKKEPGETLSCSKHVDGQVTQENIFSNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPLEKTVIKSEYSPGLTQGPSGSPQLRPSSAGPAFSMASSGLSASSPIPSVPQSQAQPPPATGAARALPSWQEVSHAQQLKQIAANRQQHVRMHQQQQQHQPTSWPALPSSAGPSPGPFGQEKIPSPSFGQQPFSPQSTPMPGVTGGSNQSKVMANYLFKASPSAQGGPLDVLLQPKPQDLSRSFLNNPHPAMEPRHGSTKPLFHFNSDQANQQMPSVLPSQSKPSLLHYTQQQPQQSSITVQPQQQQQQPQQQQQPQQQQQPQPQQQQQQQPQAQQPAAQPTQPLSNQPLLRAPLPLQQKILLQKIQNQPITGLGYQVSQQHRQDQHSVVGQNAGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLTRPPPDYKDQRRNVGNMQPTAQYSGGSSTVSLNSNQALANPVSTHTILTPNSSLMSTSHGTRMPSLPTAVQNIGIYGNLPCSQPSTYSVTSGMNQLTQPRNPNQLIANQNNPLMPRPPTLGPSNNNNNNVATFGAGSVGNSQQLRPNLTHSMASMPAQRTSNVMITSNTATPNWASQEATAKQQEALKSAGVRFPTGTTTAYAPNQSLQQAVGSQQFSQRAVAPSNQLTPAVQMRPMNQMSQTLNGQNMGPLRSLNLRPNQLSTQLLPTMNQAGTGLSQSRTVSQPPSLAAGGFPSPNQSSRAFQGTDHGNDLAFDFLNQQTDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSQQLEDFLGCLQLLDTSIYKPQEQACIPVFRSLPPNLRTIIQRMVFFEERKVPESIIQAQNYQQSPNTILDLAIQLKLITKQEERQQQAVNSYYYLDSNFQNSLRDSIEGKSKSILTKIGDCTENKELLKRECSRKWKDLFDLISRRDRSDLSCYRQQVRQTLIESKLLERNLGVGFSFILSSTHKQINQILKYYVTKQSSNVVRFILCLSVLDPMKIYQMPNEEWQKNVIKDLQEFGLTHYQDQQMRITFLFWNFLYEPPSVSIGIQCNIIVEANFRIYAYLNSGDQQEEEILCNLLNLFSEIKKRFKILIIADLSESSIRKAVRENLQAKQIIQFLEMNSKQLKQQAATEKQHKSNDELKKRLDFLRVFQEGVPEKAIIPHNVVQQIQYWESFSNIK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEDVTDLHPPQLSPCWFCQSHIKNGGVLRMFTCSSPSLESEVPVVSPKPRVLNSALDSMERFPFLTTDRGLVVFTDVAIHFSQEEWGLLDEAQRSLYHSVMLENFALLSSLGCLHRAQDEGAPSEQGVSAGTSQVRTPKPGPSIQDAQPCETCGLLLKDLLHLAEHDGTHPGLGLYTCGEKPYQNQKHQIREKLSKSDEGRSSLGKNYRGHMTGMTFTCREDGKHFPASSGLLQEQVLHVVEKPHWDMAGGEAFQNEQNYYKCTRCRKTFSHKHMFVKHEKIHTGGKLYEQRECEKAFLRKSHLHQHEIGHDEDQLYENPKCRGFFTQIPGLSDHRGIHTRLRPFECSQCGKGFLRLSQLVGHQKIHTGERPYGCSECGKFFRNRSTLIRHQRVHTGERPYECSECGKAFTRKHKLVEHQKIHSGEKPYECRECGKAFSRKDKVVEHQKIHTGERPYKCAECGKAFSRKHKLVEHQKIHTGVRAYECRECGKFFMDGSSLIIHQRVHSGERPYECDKCGKFFRYRFTLIRHQRTHTGERPDGCNNVGNPLVATPHSLDVRQITEEKGLIIAANVGSFCGTTPVSLHNREFTLL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MAMDQSFEDAYGELYGEGAFSFNNNTKPDPITTSLPSEDTNNDSSFDCNICLDSVQEPVVTLCGHLFCWPCIHKWLHVQTDEHQRQHKQCPVCKSKVSHSTLVPLYGRGGDNSQEKDKTGDVPRRPVYKLEMANSSTDLRLSQRVHFDNRHGGYYPVSGVMSSNSLSYSPVMDPMMVMVGEMVATRLFGTRVMDRFTYPDTYNLAGTSGPRMRRQIMQADKSLGRISLFLICCVFLCLLLF
The following text describes a protein:
Function:
Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.
Sequence:
MAAPPNQGFDTSSLSEKDLRIFRLYGRLPSNLASKPQSTSAPSSTSTTPYTSPLNSGSSLQPATVTSTGPSATNNAATTRFARHLRERKYFDSGDYALSKAGRGNSVDVGMIGSAHPAPEEIPHPSPLSIMQRRRGSSFCGGVSGTFHLGTRDGEGEDDGGGLADSPGLGGWGRYRRSSLSVEVVDADGGYEVGVDGRK
The following text describes a protein:
Function:
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
Subcellular Localization:
Secreted.
Sequence:
MRLLLFLGSLLGSLESVLLTPPWKAPKVHNHRADEHTVVLTVTGEPCYFPFQYNRQLYHKCTHRGRPGPQPWCATTPNFEQDQQWAYCLEPKKVKDHCSKHSPCQKGGTCVNMPDGPRCICPEHFTGKHCQREKCFEPQLLQFFHEKEIWHRLEPAGVAKCECRGPDVHCKLVASQGCHTNPCLNGGTCFQAETHRLCRCPTGYAGRFCDVDTEARCYHGRGLDYRGAADAALSGARCQRWASEASYQEVPAEQALSWGLGNHAFCRNPDNDTRPWCFVRSGDRLSWEYCRLARCQAPGLAIPQILPPTQVPSGRPTLPVPSPSALQKPQPPTPASSATREQPAAVPSSRCGQRLRKRLSSLSRVVGGLVALPGAHPYIAALYWRHSFCAGSLIASCWVLTAAHCLQDRPAPGELTVVLGQDRHNRSCEQCQTLAVRAYRLHESFSPVTYQHDLALLRLQETADGRCALPSPFVQPVCLPSGAARPAEAQAEAALCEVAGWGHLFEGAGEYSSFLQEAQVPLIPPQRCSAPEVHGASFIPGMLCAGFLEGGTDACQGDSGGPLVCEEEASERQLILRGIISWGSGCGDRYKPGVYTDVASYVTWIQEHTNS
The following text describes a protein:
Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Sequence:
MGVLRWRDSPGSRISGSIGNSSGNSNNNHHHSSNSNSSSGNNNAHQQQHNNNHINNNMNNNNNRENHHRGSNASEERVPQPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAHTLNENITVDHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFIDTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTPNLNTCSRTASKSSSKSKSSNESTSSSPDITSRQANNNNTNSIGGHLPQNGTGGGVVAAAVSAAQNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGLESMSSAEATTKACSLCLDGVQSTIMGSSPSNETIVKIENLRQEVTRLKCDKLDLLRQNVTCQRDIKRLRERELSLQGDLSAAGREILRLRDLLKEYMPDTASAPLSISPI
The following text describes a protein:
Function:
Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5/pantothenate, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. The catalytic activity is not CTP- but ATP-dependent.
Sequence:
MSSISGLVEDEISSFFESSPPLKNKEEIVANLNQFIELNSSCQGGMRRIVCVTSGGTTVPLEQRCVRYIDNFSSGNRGAASTENFVKAGYAVIFLYRRGTCQPYCRYLPDDPFLECFEFPDAKNIQVHGSHSGAVKMAVMDQQAAVAEGRLLKLPFSTIYEYLQMLRLIATILKDVGPCSMFYLAAAVSDFYVPWLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWAPKAFCISFKLETDSKILLEKATKALQKYKVHAVVANELLTRKEEVVVVSSSGNVVVRRDSNKPESIVEDNLIRLLVDRHSTYIKESLT
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells. Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5. Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Cytoplasm.
Domain:
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Sequence:
MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS
The following text describes a protein:
Function:
Transcription factor that is specifically required for the development of root hairs. Acts with RHD6 to positively regulate root hair development. Acts downstream of genes that regulate epidermal pattern formation, such as GL2. Acts with RHD6 as transcription factor that integrates a jasmonate (JA) signaling pathway that stimulates root hair growth.
Subcellular Localization:
Nucleus.
Sequence:
MSLINEHCNERNYISTPNSSEDLSSPQNCGLDEGASASSSSTINSDHQNNQGFVFYPSGETIEDHNSLMDFNASSFFTFDNHRSLISPVTNGGAFPVVDGNMSYSYDGWSHHQVDSISPRVIKTPNSFETTSSFGLTSNSMSKPATNHGNGDWLYSGSTIVNIGSRHESTSPKLAGNKRPFTGENTQLSKKPSSGTNGKIKPKATTSPKDPQSLAAKNRRERISERLKVLQELVPNGTKVDLVTMLEKAIGYVKFLQVQVKVLAADEFWPAQGGKAPDISQVKEAIDAILSSSQRDSNSTRETSIAE
The following text describes a protein:
Function:
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MATLNQALVLALESNPKEAYVVAAETLLRLLDNIIREPQNAKYRTVRIDNPSIREKLLSVEGMKQLMLAIGFVESNGTLTVPSNVLLANVRRYREFLYERKELVKNPPKERDITPIGSVTCTESNSSTASAAVTTTSTTNIPQEAATEKSNMVLQPSGSNATAGQQRTEALCVIKSSRPFLARIEFPKVIPGNNTLLRQLELLSDQVMQYEDELLLASGTSLIPIDKLTAKAKSKLTQWQRLLASSEATDQNKEPSEKDLLLEELTAWFRAEFFTWVNALPCTVCGNEKTQLVRSTVEDGVRVEVYQCCGQLRHFYRYNDVEKLLQTRRGRCGEWANCFTFLCRCLGYDARYVFSTGDHVWTEVWSERRQRWIHVDPCENVLDAPLMYEHGWRKEITYVFGFARDDVQDVTWRYTNDHQRLLQRRRQGSACSEHALLDAIAKLRTKRRAGLNCTPEQMSLLRKRTIDECLELLANAGRVPTAAEREGRSSGSLEWRLQRGEQQTNTRYMFIPTEEEVQAKQFNIRYCCATDCYERFLKGASNRVNERITEKSNGWESRQYVSRNIFRKEELDWKMVYLARTEGTDEATIEWNFDFSVQGLRVKQIELRFGQETYEGAKVELYYIKSDGSQSQALSSLCECGKFTLQARLSGGKSWQHAQLFRQSKTATDEYPFEMNIVLM
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVVVLMGGRSSEREISLKTGKAVAKALRELGHEVYELDLDKELPCKLLEIKPDKVFIALHGRYGEDGTVQGLLEILDIPYTGSDTIASAVSIDKDFTKRIVKSLGINTPDWETFISEGDVLNTEWNKFPAVVKPVREGSSVGLKIVESLEELKEYALDLLKKTERVMVEEFVEGRDMTVGILKGEALPVVEIIPKKGVYDYECKYTKGMSEYRILKDEKLSKKLQEISLKISKFLSLKDFARIDFRVTKEGKIFFLEVNTIPGMTELSLLPMAAKEKGMDFKKLISIIIT
The following text describes a protein:
Function:
Required for chloroplast photorelocation movement; chloroplast accumulation upon low blue light and for chloroplast movement to the bottom of cells in darkness, by modulating chloroplast actin (Cp-actin) filaments distribution, appearance and disappearance. May mediate a slight resistance to aluminum in root hair cells.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain co-chaperone activity is required for chloroplast photorelocation movement.
Sequence:
MQTLPSSETVLLGSNSAPPVLRSPGGDDVDIDFGDVFGGPPKRRSKVTSNEVTRHSFSESALRRRDVIVDVGDLLPQDEKPVFGEDTSSVRRRFTTDDFFDDIFRVNESSSLPGSRILSPAHKPESSSGTSSPSQFSLPAKATEIPTFNLAATRSLNKNKETVSSSPLSRTSSKADVVSTAKSYSDDCDDPPQVFVTGKGRQFHFSIYKWPNKGVPVVIWGSSRLSSMSKAEETTPVPLSDYRKTSVVEKLGKNEEGDGKSGLSGLKDVKKTSLKRPGVQTKEEKTETDLKSEQAFFGVSKAREANVKPLDSVESEQAFSGVSKAHEATTVKPLHSIFHEEDERQDEKIVSEREVRKGKSKAKNTRSFTEDSRTKKKSQGTKSSLDSSPIPDKSSFASSSAAPEVGKDGVKGKVSDFVKIFSKGASVGAGGESLGQSSRWRAKETPKTDIIHDGSNAKETVNIPDQQKKSTPDIPAMNRDQKPSQSTQKKDSDRESMNYKAPGDTVQEERQEPSTTHTTSEDIDEPFHVNFDVEDITQDENKMEEANKDAEEIKNIDAKIRKWSSGKSGNIRSLLSTLQYILWSGSGWKPVPLMDMIEGNAVRKSYQRALLILHPDKLQQKGASANQKYMAEKVFELLQEAWDHFNTLGPV
The following text describes a protein:
Function:
Endosomal sorting complex required for transport (ESCRT) component regulating multivesicular body (MVB) protein sorting and plant growth. Required for the formation of intra-luminal vesicles (ILVs)in MVBs. Binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin. Controls IRT1 recycling to the plasma membrane and impacts the polar delivery of this transporter to the outer plasma membrane domain. Regulates ubiquitin-dependent membrane protein degradation, vacuolar transport, autophagy, and vacuole biogenesis. ESCRT component that binds ubiquitin and regulates vacuolar sorting of proteins. Attenuates abscisic acid (ABA) signaling through RSL1-triggered degradation of the ABA receptors PYR1 and PYL4. Interacts with PYL4 and PYR1, and delivers the ubiquitinated ABA receptors as cargo to the vacuolar degradation pathway. In response to ABA, is phosphorylated by SnRK2 kinases which mediate FREE1 nuclear import. In the nucleus, interacts with the ABA-responsive transcription factors ABF4 and ABI5 to reduce their ability to bind to their cis-regulatory sequences of downstream genes, thus leading to transcriptional inhibition of ABA signaling pathway. Negatively regulates salt stress tolerance via a negative feedback loop involving ABA signaling pathway.
Miscellaneous:
MISCELLANEOUS: Reduction-of-function FREE1 alleles exhibit enhanced sensitivity to abscisic acid-mediated inhibition of seedling establishment. Seedlings overexpressing FREE1 exhibit increased sensitivity to salt stress.
Subcellular Localization:
Cytoplasm. Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome. Endosome, multivesicular body. Nucleus. Note=In response to abscisic acid (ABA), SnRK2 kinases phosphorylate FREE1, a step requisite for ABA-induced FREE1 nuclear import.
Domain:
The FYVE domain is required for PI3P binding. The N-terminal domain (31-86) is required for the interaction with VPS23A and B. The C-terminal domain (515-601) is required for the binding to ubiquitin. The C-terminal coiled-coil region is required for the interaction with SH3P2.
Sequence:
MQQGDYNSYYHHQYSQFQNPTPNPNPNPNPSPPAPATVAGPTDLTRNTYASAPPFTGGYGSADYSNYSQNYTPYGQNSEHVPPSAPSFTSPSQPPPSPPATSLNPNSYSTFNQPPPPPTIHPQPLSSYGSFDSTAPYQQPTSQHMYYSPYDQHQTSGYSSAPPPSSAPAPNPNPAPYSSSLYSAPPYSSGGSSIPPSYEKPSVKFDQSGYDGYNRSRSDLGSDLYGKRSDSGEYPAFEDSYGDGVYAYQGGKVEPYGSRGTAPKSSNSTLFDDYGRSISFSSSGRDSSVSSNSAKIVRAVPKADVQEDSTGGVQKFRVKLLAETYGQTTTDVLCQIGLDGLRMLDPSTSRTLRIYPLENITRCEKLDSSILAFWSKTPVDIEAKRIRLQSNSYTTNTLLDTVTAAMFQAKEIGGSSRPPTSGKLIEQTAEKKKGLGDWMNIIKPVNEEKDHWVPDEAVSKCTSCGSDFGAFIRRHHCRNCGDVFCDKCTQGRIALTAEDNAPQVRVCDRCMAEVSQRLSNAKETTGRNVSLQSHEDLARKLQEEMERNRKSSSGLREGSGRRMKEVACPTCTVHLQVQVPVSGSETIECGVCQNPFLVSAH