lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MFAKLHGKKQRPISSINSQTPRTSNTTHANSISLSSGNLIVGSNRNLRQKKEQFGSQQRASGRKLISNKENDDNVNNGGDNNYDNGERVHRHHIPGLKIKAYQAELGYHESRFSENLVMLNLVEFPDIKPGDLVELKTYHKNPSASNGDKKIYFIAKDFDGETKRRAKTSNVSILSGQLQTLLDLPSRSRIWIKLKPNKFDLQADVVEFNIKDCLLNRGDMWVLSSKLVDTCVFMDQRLAFLDSIRGTIKGIYRNGKKIVSGYIGEQTRIIFRSESARLIFLIQITDEMWNFEETGEQLFQKMVNSFFPKIFKKWKDVDTHHTITIAFAISMDLSDTSFKDLTPGESLKNSQDYFRIVVDQVSIIHWVDIMETLREEFMEIRKDLLNKQTDKGYSVANGRFSPVIKSNFLELVNFATTILTDPFKQLDLRHTTTHVMIISPGSGLFDVDYSLLRLTGKKLLSLEMTMDLICLSKAPLHIVPLFRYRDFENKLHHCVPLWLSVFFWNDHDKKSNSEWTPRCKIYDLQMMGITENELIREVDVEYLQLNKKVKSLSEFMNDYDKNAFEVKILCAGSNTKQSKKLNSKFDTVFENDVVVKARKIPATATTTHGNTKFIWRGPKVALPAIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKISTPTTSNNDNLEMNDSLVSVRSADNQNTSLALDSLKGLSKRNSLKDFTQRVITKFISNIDTSKNKKIKSTLLRDDVDNSPLGSNTPLPSSESKISGLKLQQKGLADENVISKRGNLIIKKNLSIFGLPSNEIMSGSPSSYLGSSHTRTSSKLSNMSDKAAFITEGQKSKHDDSNTYSLTQQLKHRISETWVDIKSPSIPVSSEFANELLPIRWKDVWPKYVARKYSKWRSFTTPAELPITISDFPSKDDFDRNFIFRNHSVTLNTDQEQYNQTYKDLLRDMIYMRLLTGFQICVGRQVEKIELSRESGESETVVNKYLDFNQNDAFKLYLMIDSEIHRITCSSSGIIDVERYLRKDEANLFDQVPSYIPLVKTRYESSFRDAMIDPLHVKRESLNWNQIDQVLAGYGDNLIDRKWHGFRAKYVVLPTDIPPNTYSMVINGKSETLNPEEIRVEGLRRLIGSITRSRLRTEKEKKGRKTKREEIQPEVMFYTGPLYNFINEQQTSLESSAINFKDSIFVNDNNLLNRNVELSKLAYQIQRGEDRITLVNRKWHWKKHEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKHNFLDGHYFYQFSPEYVMDTNKLEKTNSHRSTLSDPKQMLRKASTGSSNDPSAMTPFSSVVPAISASNASVADAKEPSRPILMLSNSLVIDVDPAGKSSKQESCTVHYDRVHNPDHCFHIRLEWLTTTPKLIDDLVGNWSRLCERYGLKMIEIPWEELCTIPSVNPFHSFVEIKLAINPWEDPEFKDRELFAKSKFYYHVYLLKASGFLLDNRASKFLQNQDIEFDIMYSWGKPQFKYVQYIHHTGAYVAELRENGCLFLAPNNIYISRVNPGNIIGKIHSASSSSLDAQKVILNFKSTCLDYQKLRSIFLDAKEMWITGKIVED
The following text describes a protein:
Function:
Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MASIPHVHSLVLDATPLITQPYAHYKGYAQNFYTTPTVFHEIKDENAKKNLDIWQAAGALKLRHPSESSIKRVSDFAKLTGDASVLSANDIHILALTYELEVELNGDKGRLRRYPGEALVPKAAPPPEQPAGEKKKRRRGGKKQRAKREEAAQQAAARDEPVETADGTESPEKSAETPVEGLEEPALAAQAAEELTEEYDEADDDGDWITPDNLTEIMIQDSGEDTTGNEGVAASDSALYNQVALATGDFAIQNVALQINLNLMNFTSGMRIKKLRNYMMRCHACFKLLPTPRDGRPVHFCPSCGGAGTVLRCAVSVDAETGAISPHLKANFQWNNRGNRYSLPSPLSKASQKRFGNKGFVHTRHQQEVPLLREDQKEFQQAMKQEDWTRRHNEKVLNSWIGGGSADNYMSPFAITGLKHHSVRVGRGRHVNSSNKRK
The following text describes a protein:
Function:
May play a role in cell wall modulation. The N-terminal domain exhibits lipolytic activity. In vitro, hydrolyzes various p-nitrophenyl (pNP) esters. pNP-decanoate (C10) is the best substrate, followed by pNP-octonate (C8), pNP-laurate (C12) and pNP-butyrate (C4). Exhibits lower activity with pNP-acetate (C2), pNP-myristate (C14) and pNP-palmitate (C16). Can also use tributyrin. The C-terminal domain catalyzes the biosynthesis of cyclic AMP (cAMP) from ATP. It has a guanylyl cyclase side-activity, corresponding to 7% of the adenylate cyclase activity.
Miscellaneous:
MISCELLANEOUS: Expression in M.smegmatis leads to altered colony morphology, growth, cell surface properties and cell wall permeability. M.smegmatis shows enhanced biofilm formation and survival under lysozyme, acidic, nutritive and antibiotic stress conditions. It also enhances the infection capability and the intracellular survival of mycobacteria.
Domain:
Composed of an N-terminal alpha/beta-hydrolase domain and a C-terminal cyclase homology domain (CHD).
Sequence:
MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPSLYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAVGCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARPLWAPDYPVGAQVRRADPFLTVALEPDAVERGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVRDVLGHIEAPTLILHRVGSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEFITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGREVNTAGDGFVATFTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MNHSSSHIHNTSTQKQHKHTTKRLTEDQVRLLESNFDSSKKLEPERKQQLSHQLGIPPRQIVIWYQNKRARWKNQSLEHDYSRLQLQLEATLVETKRLQKEVEKLRTELNKVQAQQVQQARHHKYYNNNHRPPMDYSNFVCGEEVGSSSISLEDNVNNLYHYGDQVFEVEEMYAASCMMGYDLRLDGSERNSF
The following text describes a protein:
Function:
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
Subcellular Localization:
Secreted.
Sequence:
MRPSIISLVALSLFLGLAYAGGVEEDKRDNVCTVKANGKQKDDVPNLLRAFNECGNGGTIIFPEDQSYWIGARLNPVLNDVSVQWRGKWTFSDNFDYWRNNSFPVAFQNHRAGFLLVDSTSPLMDTVPEASMATAIRDIPQKRASHNLDRCRSSFGTSMKLMSGTFVKDPPLWSLNIINGTNMRFNSIYCNATSVDAPYGHNWVRNTDGFDTMDAVNIQPTNFVYQGGDDCIAIKPRSYNIDIEDVTCVGGNGIAIGSLDQYLEDSNVENVRVDKLNVAPLQTDYCLHAQLRVYKNMGRLSGAPKLIRKRWSPSQWRLGQCYTSGGTSVTSKVSCSEVHPCYNIEFDNVVLYSGKNASSPRTGSCKYTANGGVHGLAGCWLSWREIVEIVSSSLRRNTDNIPSLECYQRHREPCRV
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MTLQRSCFVDLSEKRDMSDVGGATYDEEALSVSEMLSSHMDVSRATELSQSMASERFSPTESPITACCSADQTGIFSCTFCRKPLRAANTIRRSKLRSRNLDDCGTAPHESTAVTSTDRSDNELEMRLGQNRSINSEHSEAVMQNDSDIPNLSSENLCRKHRRNSVERGVTKQSTWRVHRRILPAIHSSVTIVLLQVLLFCTVNVAAVWWNPGYRPTLMDSERICLWAQQIGGPQAEMCANEMPVVEEIKKGIQRGAYNCAREFRYSRWNCSQTPKKFYEKALWQTTKETSYLQAVTSAAMTFAITEACSLGNIPECGCVNTRGQKREYLRREAQKRNYYINESYLDTFVDQFDWEGCDDNVDFAYRKTRHFLNFTRFIGRKRKINLRLRMSAHNYEAGRLAITEKMAEKCKCHGFSGTCTIRTCWMRMPKFDAVRATLRRMYNTATKVNLQPGTRRLVIARRPRRPSSRHRNTASRRTNKVKRGLRKNIPTRFRSRNRKAKNPRRRIRLKNRLRRRLYPVASKHLVYHQPSPNFCRRDKRKGSLGTKGRVCDPTRREGYGSCQYMCCGRGYTTEVVEHTMKCNCTFIYCCTMTCDECINRYTRYVCR
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MANDHRRMFEPRAIKLFMFALVLIVNQATMAQTMNNEETVDEIGVILDLRTRVGKEIKTSMEMAIRDLQDSRHSRVVLMHLRDSHGDPVEAASTAVDLINNQSVKAIVGLQTRDEAAFVDQLATMAQVPVLSFSRPYPPCTTCHSTPTFLIHMAYNDSLQMRALAAIISSHQWKLVNVIHDEADSTTGIFPFLNEALLSVGAKIEQRSVLPTRASLHDMTGTVRKDLQRLRATQSRVFVVHITSMDLANLLLVEAKRMGMMNNECVWLITDPLTALLDSMDSASISLMQGVIGVKTSFIHKTHETREFFLRFRQQFLSEYPEEERANPSIYALHAYDLIMVLAQSMKSVGAKRENNSIITWVQSHNATKRAWDLRVSLDGPQLIKEITSNVSRGFSGDINFANKELHSSIVQIINVVGQGYRDIGFWSPETGFSRDEKASEGKSTSINNTPSPLIFPGGPSVTFPKGWVVPSDGKKMRIGVPLKTGFKEFVEVKHNKTLNTTEFRGFCIDVFYRVLDILPYELRYEFIPYVGSYNDLVYEVNQKRFDAIVGDVTILANRSQYVDFSHPFAESGFSLLVTINDENSHSAWMFMMPFTMGMWLVTGALFIYTSIVVWCLEHKNNPDFGGSLWDQIGTVLWFTFSTLFFSHRENVKGSLSRMVIAIWLFVVLILTSSYTASLTNTLTIKRLDPTDTSIESLLRNKSTVGCQHTSFMVKYLEEVLGFDPVNIKKITSADELSEALSNGTITAAFIELPYIKVFLSQKKCKGFTINEPTYRVGGVGFVFPLGSPLTSDVSKAILKIKEHGEMLYLERKWLFSTECSKVLTDVKDDDDSLSLDSFWGLFLITSGTTTLVLLLFFLNLLHGYRHLENVEDGGGRAKSMQAFMVALYKYWDEPQIQTLDMRIEMENNGEHSNESSISKT
The following text describes a protein:
Function:
Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.
Miscellaneous:
MISCELLANEOUS: Present with 2157 molecules/cell in log phase SD medium.
Subcellular Localization:
Lipid droplet.
Sequence:
MHRTYSLRNSRAPTASQLQNPPPPPSTTKGRFFGKGGLAYSFRRSAAGAFGPELSRKLSQLVKIEKNVLRSMELTANERRDAAKQLSIWGLENDDDVSDITDKLGVLIYEVSELDDQFIDRYDQYRLTLKSIRDIEGSVQPSRDRKDKITDKIAYLKYKDPQSPKIEVLEQELVRAEAESLVAEAQLSNITRSKLRAAFNYQFDSIIEHSEKIALIAGYGKALLELLDDSPVTPGETRPAYDGYEASKQIIIDAESALNEWTLDSAQVKPTLSFKQDYEDFEPEEGEEEEEEDGQGRWSEDEQEDGQIEEPEQEEEGAVEEHEQVGHQQSESLPQQTTA
The following text describes a protein:
Function:
Positive regulator of ferroptosis. Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis. Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQKEDGRGGRSSQPQQVTQRPEEGKESLSKNLLLVALCLIFGVEVGFKFATKTVIYLLNPCHLVTMMHIFLLACPPCPGATVIFKLQMHMLNGALLALLFPVVNTRLLPFELEIYYIQHAMLYVVPVYLLWKGGAYTPEPLCNFQWALLSTGLMFFYHFSFLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID
The following text describes a protein:
Function:
Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion.
Sequence:
MGEIEGSYRVLQTPGTRLGAQFNAGISTLEAGQSLSGNMVSGSKSPGRGLQVRVKGLDDSQEFFDIDPKAFGQTLLTKVFLRGNLMESDYFGLEFQNMQMMWVWLEPTKPIAKQVRKPANTLFRLSVKFFPPDPGQLQEEYTRYLFSLQMKRDLMEGRLICSENTGALLASHLVQSEIGDYDDVADRDFLKANSLLPYQDKVQEIIMELHRRHLGQTPAESDFQILEIARKLEMYGVRFHPAADREGTKINLAVAHMGLQVFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPEVHGPHQDILEFLMASRDQCKVFWKICVEYHSFFRLFDQPQPKSKAILFTRGSSFRYSGRTQKQLVDYVRENGPKRTPYQRRNSKIGMSTRSYTTDVPKQHLSFNDSLRGAGSPLSAAAAPFHPAHTSSVLPRAELQHKPQPLSPPSQTAAPPPQTRLHSPLQAPRAPSPPKEDPVKAASPPHYSFQDTVVESPQLSPLTSKEPLCMSPSFQMSTLSLPSQAPSPLQSPLLSEVGSNARLEEEEEGRRKRYPTDKAYFIAKEILTTERTYLKDLEVITVWFRSAVIKENAMPEGLMTLLFSNIDPIYEFHRGFLKELDQRLALWEGRSNAHVKGDYQRIGDVMLKNMCALKEFTSFLQKHDEVLTELEKASKRLKKLEMVYKEFELQKVCYLPLNTFLLKPIQRLMHYKLILERLCKHYSPAHRDFDDCKKALKEVAEIATQLQSSLIRLENFQKLTELQRDLIGIENLTAPGREFIREGCLYKLTKKGLQQRMFFLFSDMLLYTSKGVTATNQFKVHGQLPLQGMIVEESENEWSVPHCFTIYSAQRTIVVAASSKVEMGKWIEDLNMAIDLAKKSQEKSSFFLDAGFGDRSNRSSDEVSLEQESEDDMSSSHTSLDKQTHHRANTTMHVCWHRNTSVSMSDHSLAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDFPLASLPLLGYTVSTPEESDGIHKEYVFKLQFKSHVYFFRAESEYTFERWMEVIKSAASTTGRMSLLIPKGGAVEVNGN
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MVNHFRIDRVGMEIKREVNEILQKKVRDPRVQGVTITDVQMLGDLSVAKVYYTILSNLASDNQKAQIGLEKATGTIKRELGRNLKLYKIPDLTFVKDESIEYGNKIDEMLRNLDKN
The following text describes a protein:
Function:
The isoenzyme MDH2 may function primarily in the glyoxylate cycle.
Miscellaneous:
MISCELLANEOUS: Yeast contains at least 3 malate dehydrogenase isoenzymes: a mitochondrial (MDH1), a cytoplasmic (MDH2) and a peroxisomal (MDH3); MISCELLANEOUS: Present with 5260 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
The Pro/N-degron targets the protein for proteasomal degradation when cells are shifted to glucose-containing growth medium.
Sequence:
MPHSVTPSIEQDSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTADLSHIDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGDSIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRASTFLREINIESGLTPRVNSMPDVPVIGGHSGETIIPLFSQSNFLSRLNEDQLKYLIHRVQYGGDEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIHGTYYVPLKDANNFPIAPGADQLLPLVDGADYFAIPLTITTKGVSYVDYDIVNRMNDMERNQMLPICVSQLKKNIDKGLEFVASRSASS
The following text describes a protein:
Function:
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Sequence:
MALTKDQLIQDIAEAIDAQKTTVRSALDQLAEIVKDALENDGEITLPGIGKLKVSERPARTGRNPQTGKAIEIAAKRVAKFVPAKALTDAING
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MIEEARRQRGPFVPSVGLPNTLRTPQEMMVERVMENCAFKSALAGVAGYGLGLVFGLFTAGMDSSMPNPMTGVADQSAKAILHDMKSRATSYGKNFAVVGLMFSGTECLVESYRGKSDWKNGTLSGGITGGLLGLRAGGKAALFGAAGFAAFSTLIDYFLR
The following text describes a protein:
Function:
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MQLVFIFFCSFSACYLRSMTQVCWLVKQDNCHQRIRLPHLETVVIGRGPETKITDKKCSRQQVHLKAECNKGYVKVKQMGINPTSVDSVIIGKDQEVMLKPGQILHIVNELYPYTVQFVEETEKPVSGGERKRKRPCDDNETDEEIKSGKVEAEPLDCSEGTSALKPPTSTRSVPDLLKGEKPSHKKASFGHWSQGLTISMYDRRMQVYRDDRVVVINDKFPKAQYHWLVLPWDSISSLKNLNQKHVKLLRHMQTVGGKMIDRCVESKRVRFRLGYHAVPSMNHLHLHVISQDFDSPCLRNKKHWNSFNTEYFLESEDVINMIKKHGKVIIPQGVSDFLNLPLCCHICKEQQPTIPQLKDHLRKHGSK
The following text describes a protein:
Function:
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
Sequence:
MSHNQSRADKSDAQLKKPGRSGNSSSGIYHKSHSSGGGKAGGGYAPPGPSIASSSFPAHNPNPLSTNQSFKRPGNGQGGQYRVNPAIVTTQTSGSVSTPSGLGMQNGSYTPPLSHVQSVAKPADISGLRTSRPIPRPPSSQTATYASNANTRVMPAKGETANSVNVQFGSINPGFVNGRTPIPARTSSAPPNLDEQKHEQTHHRVSVKAAPMMPTSFAPKKPQVQSREEVPALNPLNTVISHPPTQAKKESQSQIPFSPITAQKSSAIPVSGVPMFEKPQSSIPFSTHGPQLQSQNIMPSHPHIPFLPVPVGTPQQNPQQMYYQPHMIQPPQPMIQQGHGLTFSPIGQLPSHMNMGMDINTQMTPYSQQQTGKYGATGTRRAVKITHPDTKEELRLGKRTEYSLPVHSQTVIPFSQNPNNFYSTIPSNSFGSGPIYYPNTQTTTSSQATRFGYVSVNQPGASVSIANPSSQNTVQRRKYGPSTQGVSQQNLVQSQDFQLPPDDITGTPSIKVSLPVCKDEAINVAKSIDEVSLAQKVSDISVESLVQKQKSVSIIEPSCSSNLVIPYLDSLHKIQPDGLSPNVTSTLVDTGLVSLSTLSKEDPRITSDNFIDHQIIDDKKEIKQFQQQPQPHVDFGANTTSTSSKVVSIDSKDTRVVLDSPNCDTVPKENRVLADSLIGVSVSDESSQDKPEYTECITSTTNDVPKETIVTEVKTLKSEKKGDISSDRSDAKKAESLQEVNTIEQYDGAVTETKVKESAIKYLEHGNKSIDFKEEDVFSVSECSKIGVDIVKGNESFSDQISDNDGQIPSLNVISTDPGRLFSESDVSLIEKSVEKVPKVSSENPVFSSSTVFKDQSQAEMTSPKTTASLRKKKKKEIMSKADAAGMNSDLYMAYKAPEEKVHSVDTSESMDSSLVDPIITSLDSTKNEIIVNEEGVESKGEVEDWEDAADMSTQNLRAPDNLQLGSRSTIVTYSKDFLMTFQNNFTDLPVGFVMELDNILSTLFNSDSRSVPNSTRASDRQSTFRPEKWTKGKVTNQYVSNVTVRDIPPDGGHGPTESGFRLGSGSNPGVLRHPRGQINQYISGNMLGSMHLHTDRWQRANGMQRGLIPSPQVSQVMHKAENKYEVGKISDQEEAKQRQLKSILNKLTPQNFDKLFAQVTEVNIDNADTLIGVISQIFDKALMEPTFCEMYSNFCFHLSGALPDFSEDNEKITFKRLLLNKCQEEFEKGEKEEAEAVKVEEEGEITQTKAEREEKKVQARRRMLGNIRLIGELYKKRMLTERIMHECIKKLITQRHNPDEEDIEALCKLLSTIGEMIDHEKARDHMNAYFDIMLNLSNNQNLSSRVRFMLKDAIDLRKNKWQQRRKVDGPKKIDEVHRDAVQERQAQASRLARGPGMSSSSRRAPPMEYGHRGSTFSSSHGHRSSFQPQVRVGSGQDVRMEDKHPSEGRTLSASLQQRSANDDSITLGPQGGLARGMSMKGQPLMATPPPDLSSTVGELRRIPSGPNGYASLPDRATHYKRDQVIPKFSGNKEYKNADRVPDIPLSATRTHGVHGASAINQNVSSETNLLSEDHLHKKSLSTIREYYSAEDEQEVILCIEEFKSPNFHPSMVSLWILDSFERNDVERDLLSKLLINICKVKGSLISRAQLTQGFKSVLSSLEDAVNDAPKATNFLGRLFSKIILENLIPLKEVGELICQGGEEPGSLIEAGHADVVIGSILENIKNDRGVSSLKEILRGSSLQLEDFRPPRPLKSANMLDAFL
The following text describes a protein:
Function:
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MGSKELLKEEDFLGSTEDRADFDQAMFPVMETFEINDPVPKKRNGGTFCMAVMAIHLILLTAGTALLLIQVLNLQEQLQMLEMCCGNGSLAIEDKPFFSLQWAPKTHLVPRAQGLQALQAQLSWVHTSQEQLRQQFNNLTQNPELFQIKGERGSPGPKGAPGAPGIPGLPGPAAEKGEKGAAGRDGTPGVQGPQGPPGSKGEAGLQGLTGAPGKQGATGAPGPRGEKGSKGDIGLTGPKGEHGTKGDKGDLGLPGNKGDMGMKGDTGPMGSPGAQGGKGDAGKPGLPGLAGSPGVKGDQGKPGVQGVPGPQGAPGLSGAKGEPGRTGLPGPAGPPGIAGNPGIAGVKGSKGDTGIQGQKGTKGESGVPGLVGRKGDTGSPGLAGPKGEPGRVGQKGDPGMKGSSGQQGQKGEKGQKGESFQRVRIMGGTNRGRAEVYYNNEWGTICDDDWDNNDATVFCRMLGYSRGRALSSYGGGSGNIWLDNVNCRGTENSLWDCSKNSWGNHNCVHNEDAGVECS
The following text describes a protein:
Function:
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Subcellular Localization:
Cytoplasm.
Sequence:
MNSRRSPLLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAGRVTAVIPYYSYARSDKKDSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPDAHNGVVLAPDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGSLVETVSIARSMGAKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPQDKLDRAGGKLAVLDVAPLFASAIANIHTGASVSTLFT
The following text describes a protein:
Function:
Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export. ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane. When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis. Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11A, RAB8A, RAB10 and MICAL1 on endosomal tubules. Colocalized with RAB11A along microtubules oriented toward lamellipodia.
Domain:
The FFAT-like motif is important for interaction with VAPA or VAPB.
Sequence:
MASESDTEEFYDAPEDVHLGGGYPVGSPGKVGLSTFKETENTAYKVGNESPVQELKQDVSKKIIESIIEESQKVLQLEDDSLDSKGKELSDQATASPIVARTDLSNIPGLLAIDQVLPEESQKAESQNTFEETELELKKCFPSDETCEKPVDETTKLTQTSSTEQLNVLETETEVLNKEAVEVKGGGDVLEPVSSDSLSTKDFAAVEEVAPAKPPRHLTPEPDIVASTKKPVPARPPPPTNFPPPRPPPPSRPAPPPRKRKSELEFETLKTPDIDVPKENITSDSLLTASMASESTVKDSQPSLDLASATSGDKIVTAQENGKAPDGQTVAGEVMGPQRPRSNSGRELTDEEILASVMIKNLDTGEEIPLSLAEEKLPTGINPLTLHIMRRTKEYVSNDAAQSDDEEKLQSQPTDTDGGRLKQKTTQLKKFLGKSVKRAKHLAEEYGERAINKVKSVRDEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFDQIKVVQDLSGEHMGAVWTMKFSHCGRLLASAGQDNVVRIWALKNAFDYFNNMRMKYNTEGRVSPSPSQESLSSSKSDTDTGVCSGTDEDPDDKNAPFRQRPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIKASFSHDFTYLVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNAVVTSAIFAPNPSLMLSLDVQSEKSEGNEKSEDAEVLDATPSGIMKTDNTEVLLSADFTGAIKVFVNKRKNVS
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MAPTSLRSVVLLVLAVAVVVSDAQLQLSETFYDATCPQAASIVQQKVNAFVDANRGLAAALMRLHFHDCFVRGCDGSVLLNSTETMLSEKEALLNKGSLRGFEQIDEIKMELECACPGVVSCADILALVARDATAKVGGTSWPVFLGRIDGGASFADEVNSSLPERTDNFTQLVARFARVGLDARDMSFCADEHIGNDAGGHSIGQVHCGAFFERLYNFQGLNITDPAMDPEFAAMLKVQCPQTKPFGFMALDATNGTFDSAYYLDLLTNKGSLRGFEQIDEIKMELECACPGVVSCADILALVARDATAKVGGTSWPVFLGRIDGGASFADEVNSSLPERTDNFTQLVARFARVGLDARDMSFCADEHIGNDAGGHSIGQVHCGAFFERLYNFQGLNITDPAMDPEFAAMLKVQCPQTKPFGFMALDATNGTFDSAYYLDLLTNKGLLESDVALLSDPLGVEYAIRAVQDPMAFLNEFGWAMIKMGAIPALEPYGWRRHCAFVEPKY
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions; This subunit might be involved in maturation of a crRNA intermediate to its mature form.
Miscellaneous:
MISCELLANEOUS: Encoded in a type III-A CRISPR locus.
Sequence:
MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDMELLYADIPAHKRKSFEAFVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEPRRASRGRGGRMTRKKLTLNEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQPVRVPGHQTREHRQYGERFERKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDLLICQKMDMNVHGKPDGLPLFRECLAPGTSISHRVVVDTSPTARGGWREGERFLETLAETAASVNQARYAEYRAMYPGVNAIVGPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGKVVKHVDKTRELRVSPLVLKRTKIDNICYEMGQCELSIRRAE
The following text describes a protein:
Function:
Could be a component of the RPD3C(L) histone deacetylase complex (HDAC).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPSNSTPANEEKEEESEKIQKSPVDTPHTPNGSVSDNEENETSSTGEVTRCVCGIVESDDEASDGGLYIQCDQCSVWQHGNCVGFADESEVPEVYYCEICHPEFHKVYQRGRGAKQSKYLGNGKPIEASQTEESSSTPPSPATKKSSKQRLTMNSRDAALDYEEYLAIAKEKSLIPRRSRGRTSSKSLSPPAPQDESQGTEINLKQKIEEENDEILEDSKESKDENEENKETSTTNVAETDAPEEETVDTVEEIADEEKHSVKEESGEASPQSSQQSTITSISTTTRSTRKAKREAAAEDKADLPAAVAPKPSKTRKVGGRRGKSSSNDNHRIPQLHPDGTFVETITKPKGLHSRITMTEMRRRVASMLEYIGHIQVEMAAQSAGNQSSTKSSKEGPEEEKETLRMVDNLTRDLLHWEQRFSRT
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MADRSLSSSSLTRDRPPLLSKFQLQEILKEMVGKDVHVKEFRELPSYQDRNYYFRLDLDKTGSHIESPILPSSDYQDEIKTINPQYVLKILRSGESKKLALGRLDALLYLGKTGFECSRVIPLRNQEFYKMVAPPKQDGNNQEIQHETTEYIAYILSYIDGSMISTIKPTYDLFYRVGKLVGKIDSNWQGYHAEVLKGNNSIWSLRNFHELRSCIKYCKEEDWSFLETTFHTISKYFKENVKNLRQSTIHSDINQSNILVQHNQEKNDYDITAIIDYGDIDYDCLIFELGITIAYLLLVTEGNPVKPAAYLIAGYHSVLPINETEYKGLHTIIAARYFQSIVLANRQRAQDPDNDYIMSKYNRKWELLRFFTSTSQEEIYKIWDQISWNYNQKP
The following text describes a protein:
Function:
An ATP-dependent kinase that phosphorylates glucose to make glucose-6-phosphate, not active on fructose, galactose or mannose. Restores glucose kinase activity in E.coli glk mutants.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITVTIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETETGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGGEIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSARDVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVEKTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC