lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKLGTWLAASVVAWVVGFGSALSTEKLAKQAAKDGGIIRLTNVNFKRILSGPRDAFIVVLMTATNPQIGCQLCTELGPEYDTLAQAWMETHSGGVSAAEPHQGLFFAKLDFAVPQSKEVFSHYQINNVPRLLLFRPGGDLDSYEPLGIPSHTGGARVRAIIDTLKSYTGIEDFEYHEPVNWGQYAAILMMAVPVVIMLRNYWSVVVSIALFRPLWGFSCVSIVIALVSGAMFNKIKDTPYVGSSGDGNYVQYFAIRQQQVQFGVETQIISVIYGTLSAGVVLLAIGTKSIRAYYIKYNYSMHAVVHLLLSLAAILLIYISFAALLAVFKLKNFEYPFRLFKSPFR
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MMSGEYGDFNNTNNKELSLLDKLKKAWINEKYAPNLLNYEDVIIKEVMEKIEEKESLCASAISNINLQFTANIYEMEIERLKYIIKCYLVQRIKKIDKFYSSILLEIENDEYDSYKLLSEFEINYCQKYKALMDGYFKNTLLNSIPKDFQKMDSNSINRPFLNTFVFCKPREDLGDFLVDDETIDFKKTSIYFLKYLPIKSLVEGGKMDLI
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MAGGEERPPGLAPGVASSFEFALNSAAFSDRVLRLEIAAEDCEAPFVGEGSPCDSPRSIFETGLGLGGTSAKSVRPRKRRRQDDESAPRSSEVESDGNNLAVIGEHGDSTGRPVLRVKHIHVSSLLLASKSPYFYKLFSNGMQESNLKEITLRIMDYEDEAFPELLHFIYSGTIKTSDPVLVLKVMCVADRFEVVDCMSYCTQLLISLPMTKELAFVYLEYECSVPMSDVLQPVKAAAQEFLADKYKNLSMSETEFLEMPLSGIKAIFSSNNLKVFSEDLVLAFLLKWALANYPETVERRRILINHLLPMVRFNQMSCGKLRWLLSCSHLDARHSAYIVASALLYKYSSPHRVLPAISDIHCSFLERTYKHKPVKTIELERPHNRCIAYMDLKSEECSNLSPSRSIRSQAFDFAGHSFFLIVQRTVNAQLGIHCFGLYLAVEKGVSVPITIEFEFAARTKAVGDFVSNFRHIKTFTSESNQLGSRDLFNMSWGQVFSEASQFLLDDMLYLRAELTVRQP
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPMCKWTIEPTDLTAVLRISEDGVNEDPNHNNCNKLKPPDNYCHLANIICSNIIRQLVSLADSADGIFKELAEQSCLVSKRFEKLNFRVAELSEKAKNLNPTVELISLDDVMQCKPFKSGLKQYASGSGGRPEAVQTVFDRIEPIPDFDKWNCYKTEEKDPKKFYSDPNFFFESWCGQIKQEVDKLKPARKKKVAKKKEEITRKPQNVNLNKIQNRVKNEILGGRPLTVNQNSDNQSQRSINVSINSEANQVTEHDRASLNSKTSEANQNPASDSIQVARNASVKGVKNTDDVIGPQGIEFPVFYGEDVNDFPQPPIPPPPLPQTFSHAVEAGQLRNKNATAATSTTTTNIKSQPSLEGKRESRGDLLASIRNGIKLRKVDEVKREVASNKNAGQTMFDVQMIMEMRRRALEEEEEEYDEDDGDDDNDWG
The following text describes a protein:
Function:
Essential for sperm motility and male fertility. Plays an important role in the proper assembly of the third radial spoke (RS3) head and the bridge structure between RS2 and RS3 in the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSDEDDVEDDFDQEPDEVEKEEDDNEMEDWEDDYRKEGEEVSEEWLPTPLTEAMMKEGLSLLCKIGSGLAHAYIKLEVKDRDLTDISLLRSYIHLRYVDISENHITDMSPLNSLTHLLWLKADGNQLRSARLNELPYLQIASFSYNQITDTEGIIHPRLGSLDLKGNRIHQVTGLDPERLTNLHTLELRANQLETTIGINLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQIETLDGFSKEMKSLQYLNLRSNMISDLGELAKLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERLDKEYYEDEDRAEAEEIRQRLKEEQEQELDPDQDMEPYLPPT
The following text describes a protein:
Function:
Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
Subcellular Localization:
Endosome.
Domain:
The OCIA domain is necessary and sufficient for endosomal localization.
Sequence:
MSGRAEFREPNAEVPRPIPHIGADYIPTEEERRVFAECNDESFWFRSVPLAATSMLITQGLISKGILSSHPRYGSIPKLIFACIMGYFAGKLSYVKTCQEKFKNLENSPLGEALRSGQARRSSPTGHYSQKSRYDSNVSGHSSFATSPAADNIEKEMLPHYEPIPFSASMNESAPTGITDHIAQGPDPNIEESPKRKNVTYEELRNKNRESYEVTLTHKTDPSVRPMQERMPKKEVKVNKYGDTWDE
The following text describes a protein:
Function:
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome (By similarity). Involved in assembly of active chromatin. Required for maintaining open chromatin and pluripotency in embryonic stem cells and is important for wing development and fertility. Is essential for the incorporation of histone H3.3 and assembly of paternal chromatin. Required for replication-independent nucleosome assembly in the decondensing male pronucleus.
Subcellular Localization:
Nucleus. Chromosome. Note=Colocalizes with elongating RNA polymerase II (Pol II) on polytene chromosomes.
Domain:
The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3); The CHD1 helical C-terminal domain (CHCT) binds DNA and nucleosomes.
Sequence:
MSQALNESANSIGSDEQDDTREEANGTDHSGSGSGSGSSGSDSDSDSSSGNSSDGRSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQRNQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLNIVIELKKCCNHAALIRPSEFELMGLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDEILRRAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQHGDPAKKAKKSKARSKKTSASDNNGNKPMHFTANNEPRALEVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAETEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGKDKGSSGSPAKSKPNGVTTEEKEKERDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDENDADASSGLAGAPGGGIGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSGPPMGSGSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAPSGYTPEMERWQSRDRYSQDYKRDRYDGYGRSGGGQGSYHRERDRRPEKRRYPSGLPPHPYSSHYLPPNYYGLPNGAVPGLPPPSSVYRSDPRGYPVMPRDYPADYRRSDYERRTQT
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MISSVVILALLSRIVVFLLQAIFNWVVPDHNADAFRAAWPRSDAIGDRAVAWFLGGLTRWDAQYFLHIAEHGYTYEQTLAFFPLYPWLLRRVADVFVDPFLSSLLARHSALVLAGVFLNVGLFVVAAASLHRLTRRLFSKELADEALLLFCFNPASIFFSACYTESLFAAVSFGGLALLEHGHPNLATLLFFLGGFVRSNGFLSAGFLLYSGLVLNWTPFRSFLRAAVCFVPFVLFQCYAWSLFCVPDYSGRPPALVASQASEAGYKLAGRNASEWCSAPLPFSYGYVQSRYWDVGFLAYYRPKQLPNFLLALPAAAVVAGCCARFSRSPGDARHVPYVLHAGGLLLLCVLFANVQVTTRLVAAASPVLYWSTFLVADPRPRTKGLHVWADVVRNLWQRDLQCKRLVTYFAAYAVVGTALHVNFLPWT
The following text describes a protein:
Function:
Is not essential for haploid growth, but may affect diploid formation.
Miscellaneous:
MISCELLANEOUS: Present with 721 molecules/cell in log phase SD medium.
Sequence:
MSTKGLKEEIDDVPSVDPVVSETVNSALEQLQLDDPEENATSNAFANKVSQDSQFANGPPSQMFPHPQMMGGMGFMPYSQMMQVPHNPCPFFPPPDFNDPTAPLSSSPLNAGGPPMLFKNDSLPFQMLSSGAAVATQGGQNLNPLINDNSMKVLPIASADPLWTHSNVPGSASVAIEETTATLQESLPSKGRESNNKASSFRRQTFHALSPTDLINAANNVTLSKDFQSDMQNFSKAKKPSVGANNTAKTRTQSISFDNTPSSTSFIPPTNSVSEKLSDFKIETSKEDLINKTAPAKKESPTTYGAAYPYGGPLLQPNPIMPGHPHNISSPIYGIRSPFPNSYEMGAQFQPFSPILNPTSHSLNANSPIPLTQSPIHLAPVLNPSSNSVAFSDMKNDGGKPTTDNDKAGPNVRMDLINPNLGPSMQPFHILPPQQNTPPPPWLYSTPPPFNAMVPPHLLAQNHMPLMNSANNKHHGRNNNSMSSHNDNDNIGNSNYNNKDTGRSNVGKMKNMKNSYHGYYNNNNNNNNNNNNNNNSNATNSNSAEKQRKIEESSRFADAVLDQYIGSIHSLCKDQHGCRFLQKQLDILGSKAADAIFEETKDYTVELMTDSFGNYLIQKLLEEVTTEQRIVLTKISSPHFVEISLNPHGTRALQKLIECIKTDEEAQIVVDSLRPYTVQLSKDLNGNHVIQKCLQRLKPENFQFIFDAISDSCIDIATHRHGCCVLQRCLDHGTTEQCDNLCDKLLALVDKLTLDPFGNYVVQYIITKEAEKNKYDYTHKIVHLLKPRAIELSIHKFGSNVIEKILKTAIVSEPMILEILNNGGETGIQSLLNDSYGNYVLQTALDISHKQNDYLYKRLSEIVAPLLVGPIRNTPHGKRIIGMLHLDS
The following text describes a protein:
Function:
Functions as an mRNA export adapter; component of the transcription/export (TREX) complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Plays a key role in mRNP recognition and mRNA packaging by bridging the mRNP-bound EJC and the TREX core complex. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling. Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Involved in transcription elongation and genome stability (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Cytoplasm. Note=Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Sequence:
MGDKMDMSLDDIIKLNRSQRPAGRGRGGGRGARGGSARGGAGGRIGGGRGGGGGGAAGGGGPMRSRPVLTRGGRNRPAPYSRPKQLPDKWQHDLFDSGFGTGAGMETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIEAQRRPIQSQSRGGGITRPRGGAIGFSGANRRGGRGGNRGRGRGAGRNPKQQLSAEELDAQLDAYNARMDTS
The following text describes a protein:
Function:
Contributes to pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling, including calcium signaling and root growth inhibition, and defense responses downstream of FLS2. Acts additively with BIK1 in PTI defenses. Seems not required for flg22-induced MAPK activation (Probable). Required for Pep1-induced defenses. Pep1 is an endogenous elicitor that potentiates PAMP-inducible plant responses. Required during SCOOP small peptides (e.g. SCOOP10 and SCOOP12) perception and signaling; receptor-like cytosolic kinases (RLCK) activated by BAK1/SERK3 and SERK4 coreceptors when associated with MIK2 upon the perception of SCOOP peptides.
Subcellular Localization:
Cell membrane; Lipid-anchor. Note=Myristoylation and proper targeting to plasma membrane is essential for signaling function in response to pathogen-associated molecular pattern (PAMP) such as flg22.
Sequence:
MGSCLSSRVLNKSSSGLDDLHLSSCKSSSSATAHKTEGEILSSTTVKSFSFNELKLATRNFRSDSVVGEGGFGCVFRGWLDETTLTPTKSSSGLVIAVKRLNPDGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEQRLLVYEFMHKGSLENHLFANGNKDFKPLSWILRIKVALDAAKGLAFLHSDPVKVIYRDIKASNILLDSDFNAKLSDFGLARDGPMGEQSYVSTRVMGTFGYAAPEYVSTGHLNARSDVYSFGVVLLELLCGRQALDHNRPAKEQNLVDWARPYLTSRRKVLLIVDTRLNSQYKPEGAVRLASIAVQCLSFEPKSRPTMDQVVRALVQLQDSVVKPANVDPLKVKDTKKLVGLKTEDKYQRNGLNKKTVGL
The following text describes a protein:
Function:
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEDTKKLEELAYQYQLLQAQAQLLAQNLELLTLGRNEFQAVKETLEGLKNEEGEFEILVPIGAGSFLKGKIVDAKNAIVSVGAGYAVQKSLDDSIEYLEKRIKEYEEAIAKTQEALKKLEAQLGELARQAQEIQQKQAMGFSVKK
The following text describes a protein:
Function:
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger. Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLAARLVCLRTLPSRVFQPTFITKASPLVKNSITKNQWLVTPSREYATKTRIRTHRGKTGQELKEAALEPSMEKIFKIDQMGRWFVAGGAAVGLGALCYYGLGMSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSALAVARTPALMNFMMTGSWVTIGATFAAMIGAGMLVHSISYEQSPGPKHLAWMLHSGVMGAVVAPLTILGGPLLLRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFASSLGSMFLPPTSVAGATLYSVAMYGGLVLFSMFLLYDTQKVIKRAEITPMYGAQKYDPINSMLTIYMDTLNIFMRVATMLATGSNRKK
The following text describes a protein:
Function:
Protein-glutamine deamidase effector that inhibits the host cell cycle and other key cellular processes such as the actin network and programmed-cell death. Acts by mediating the side chain deamidation of 'Gln-40' of host NEDD8, converting it to glutamate, thereby abolishing the activity of cullin-RING-based E3 ubiquitin-protein ligase complexes (CRL complexes). Inactivation of CRL complexes prevents ubiquitination and subsequent degradation of the cyclin-dependent kinase inhibitors CDKN1A/p21 and CDKN1B/p27, leading to G1 and G2 cell cycle arrests in host cells. Deamidation of 'Gln-40' of host NEDD8 also triggers macrophage-specific programmed cell death. Also able to catalyze deamidation of 'Gln-40' of host ubiquitin in vitro; however, NEDD8 constitutes the preferred substrate in vivo. Also regulates the host NF-kappa-B signaling via activation of MAPK/ERK cascade: activation of host MAPK/ERK cascade is independent of CRL complexes inhibition, suggesting that Cif has other host protein targets than NEDD8.
Subcellular Localization:
Secreted. Host nucleus. Note=Secreted via the type III secretion system (T3SS).
Sequence:
MLEHGVMKIPGINNVGKTGQAGGETERIPSTEPLGSSAATSPAGPLGGLPARSSSISNTNRTGENPMITPIISSNLGLKHRVTLRKATLASLMQSLSGESSNRVMWNDRYDTLLIARDPREIKNAIEKSVTDFGGLENYKELTGGADPFALMTPVCGLSANNIFKLMTEKDVPIDPTSIEYLENTSFAEHVNTLDSHKNYVVIVNDGRLGHKFLIDLPALTQGPRTAYIIQSDLGGGALPAVRVEDWISRRGSDPVSLDELNQLLSKDFSKMPDDVQTRLLASILQIDKDPHKVDIKKLHLDGKLRFASHEYDFRQFQRNAQYVAGLG
The following text describes a protein:
Function:
NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.
Subcellular Localization:
[Isoform 1]: Mitochondrion matrix. Note=Localizes to the mitochondrion in stationary phase; [Isoform 2]: Cytoplasm, cytosol. Nucleus. Note=Localizes to the nucleus and cytosol in the exponential phase.
Sequence:
MTRTPFTLSLRSTDSVFKIRQSLSTVLSHSSTKIISRGYITIPITSTIAYHRPTIRLFNMPIAAPVRTLSSSQPLKRSTSPLPAITPAQNLLRLKAHLQNLPTPLLKHVHLSKIRREDPNLFFSVMRDELTDLAPIVYTPTVGEACQKYSQIYSGPEGLYLNIEDKDRIPEILRQYASKLVTPPQILVVTDGSRILGLGDLGIGGMGISVGKLNLYVAGGGVNPHGCLPVVLDMGTNNETIRNDPLYIGLKQSRVGLEEATEFMDAFMAAASEAFPKAVIQHEDFYSEAAFDFLARYKEKYRMFNDDIEGTGSVILAGFLAAAKQASEASGKPLRDHKVVFLGGGSAAVGVAKEMMNFFMMQGLTEDEARERFWLIDTKGLITSTRADVVSGKIASHKKFFIRNDTEGKEYPSLESVIEYVQPTALVGLSTTFGAFSEFAVRRMAELNQSPIIFPLSNPTSKCELAFSDALEWTDGRVLFASGSPYPPQQFKGTLREPGQGNNFLVFPGIGFGALQAGCKRITTGMITASAIALSEALTPEEKQKGLLYPRLERIRAVSARVAAGVVKQAQEDGVDTNETLRGLDIEALTEEMNKAQWWP
The following text describes a protein:
Function:
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton.
Sequence:
MQRSRASSTSSGRHPAPPPIGLPQPQAQPLEAPKIIVIHPGSQHLRIGRAADLNPLTLLHAVAYRRRPGASDRPHHDPLLPPLDNVNSNSGLMVEFEEQRLVVSRILQHCVVDNKNRLRVATPPQQLAHFNRSSQAEKVPAPSGQMADEPWLDREAPVLFDDRILRLGAVDARNYDIHFPIQRGELNVHNEKGGSLQASMQHLERIWSYALEERLKIPLRKLGTHCAVLVVNDVYVRRHLREFVTLLLRRLGFRRCFLVQDSVASTFGAGIGYGCVVDIGAQKTSIACIEDGISQLDARVRLSYGGGDLDQVLLLLLRKCGFPYRECNVQESYVDAHLLDELKEKFCHLNASVCGAQEKHFNLRKHNGQWLRYTIQVGDEALMAPLALFHTELLNITGRTKAVFTQQAVQDQYDCEDCFDAEYLKETGRKNGVRGGDILQLSTSAGYQPRPQLPVTADDEELIVVDQDETISNCQSQLGAQTAGGQMNSNGCYHNGQGLVLPLDQAIIQSINRLSSYETKRKMFGSILLVGSSAKLPGLAAWLEQRISQQVQSEVNVLIKGMDAGMVAWKGAAIMSVLESARELWISQNDWQRHGLRVLRERSPFLW
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane; Peripheral membrane protein. Nucleus.
Sequence:
MVLRAILDLGAKNRLENLWLNGPEPASVSGSDTPFPHFLSPRSAALRMDPGPAPDGAPIAGLAWALASAVPPRGYSAITSTVEGTPANFGKGFAQKSGYFLCLSTGEIGTGSGNSSETLPENVVTDIQILNEKTPLPNGFTYISEFLDTKASVSKKKRVCMKLVPIGVADMAVFDVRLSGKNKVVPGYIRVGEIGGFAVWCKKGKVSKPKPLPKPRSISLEMKGLSLDRSSDSSEKLSPLSSRQGTIRRSDSIYEASSLYGISAMDGVPFVLHPKFEGKDNGPMGFSALADLTIKSLADIEEEVGFGPLPHSHVYSCPRFLPSSLKPPDTPVR
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain.
Sequence:
MDHNTDPPPTTMVDAAAALLLEPKLEGYDDDGGGEPLQPAPFVSPLDQLMQPPRPLEALLQGPQLPPFLSKTYDLVCEPELDGVISWGHAGNSFVVWDPSAFARDVLPHHFKHNNFSSFVRQLNTYGFRKVHADRWEFAHEDFLRHSKHLLKKIVRRRSSPTQQSGLQPGSSGESGLDPELNTLRREKSALLQEVTRLKQEHLQTIEQMSTLNQRLESAEDRQKQMVSFLAKLLQNPTFLRQLKMHRQQKEIDSTRVKRKFLKHVPHGNIDSGESSSQHTGESNLDFSPTSLDLPATHSDILDLQNFLLEDGDLNLAMLPENIGLDGIEAPDDIGALVQGFDTQEELELGSGVELLEIPPASGPRGQDPTIGRSKGKNVLSPGLDATSSEADCLGSFSDNMGMLSDSMLQTAGKLMDADDDERIWGVDASSALQSSCSGTSQQAYGSLVSDPYLMEMANKPEKFWELDFQALDDGDLQLDKCVIDDPALQQQRGNMNS
The following text describes a protein:
Function:
Blocks voltage-gated potassium channels rKv1.1/KCNA1 (IC(50)=13 nM), rKv1.2/KCNA2 (IC(50)=16 nM) and rKv1.3/KCNA3 (IC(50)=2 nM).
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
IKCTLSKDCYSPCKKETGCPRAKCINRNCKCYGCS
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MVRRFKRGTKYRRGSRTHGWGRVGQHRKSGGSGGKGMVGFHKHKWSLVMKYGESGTGWPFYGKHGFKQPPPISIEWRPINVGTLAELVKELKAEGKVREEGGKYVINLLELGFNKLLGGGTIDLPVIVYTPIASRTAVEKIEKAGGEVRIIHVIHR
The following text describes a protein:
Function:
Component of the DprE1-DprE2 complex that catalyzes the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate channel' at the interface of DprE1-DprE2 complex. Can also use farnesyl-phosphoryl-beta-D-ribofuranose (FPR) as substrate in vitro. Appears to be essential for the growth and survival of M.tuberculosis; DprE1 is a highly vulnerable and fully validated tuberculosis drug target.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Periplasm.
Sequence:
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
The following text describes a protein:
Function:
Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.
Subcellular Localization:
Cytoplasm. Vacuole lumen.
Sequence:
MVSSAILLLPAILIAINTHSFSVNTQQLIFTNNNQLNTQDHTCPANPPTSCHLSSGDGKEPVNSCCTNTPGGQILLTQFWDSHPATGPSDSWTIHGLWPDNCDGTYEASCDSGRQYHNITQILEQGGGQEALSVMKEFWKDQHGNDETFWEHEWAKHGTCISTLEPHCMGSSYKPQSEVVTFFNRTVDLFKSLPTYEWLKAANIVPSATTTYNLDQLQEVAKQYTGQEAVWNCRGHVLNEVWWHFNTVGTVADGKFVHASPVGPRSTCPYKGIQYLPKGHSGGGGGGGGDHRPKHPGHQPGNPPSDRKHFIYVVDEHGQRNGCLISNGNWLSRATCASFSVSVGHDDKALLEIRTRRGACAFEDSGFRCAKGLKSEGFEKNGDRLVYEGQEVFYSDKLPEGTTQVPILKSKSKNSIYLEIADAH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLPFKKADSPFKSNPVSRVGSSTRLNQLGNIKSNPTTPNAALYVTSSLNPSKNLPTNAANVKSRLQTQKDLDAFKQLPMVQKVNEYERLLNELSEAVSQFKNDELQEKIGQIITCNDVLKQQIEDLNKHRNYSYEVDKLSDRNKILEENSKFILKELVSYRNELKKLPKLPKSDKMVNRNVDVDDILKYAFKLAKFTKAPATVANMPFQIHPNNYVWPAEDSLRRGMLAQASLQAEEIIRHELGETDKENSNEVKTESKVDHDDDDDDEMEDVRISNENTNDEQRSKPPAASEHDTSKRKEEQNQQPVDLNLDLFDPDDEYSD