lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Subcellular Localization:
Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Membrane; Lipid-anchor. Nucleus.
Sequence:
MKVSRAYQSELESEEGKGVSSEQIEQLHRRFKQLSGGQPTIRKENFNNIPDLELNPIRSKIIHAFFDNRNLRKAPNGLADEINFEDFLIIMSYFRPIEPNMDEEQLERCRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIGKESARSIADGAMMEAASICVGQMQPDQVYEGITFDDFLKMWQGIDIETKMHVRFLNMDAIALCH
The following text describes a protein:
Function:
Probable ubiquitin-protein ligase involved in pre-mRNA splicing. Acts as a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. It is also probably involved in DNA repair.
Miscellaneous:
MISCELLANEOUS: Present with 11700 molecules/cell in log phase SD medium; MISCELLANEOUS: The tetramer is an elongated particle consisting of four globular WD40 domains held together by a central stalk.
Subcellular Localization:
Nucleus.
Sequence:
MLCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTESTNSATLKANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEKNEDSKDLPKSSQQAVAITREEFLQGLLQSSRDFVARGKLKAPKWPILKNLELLQAQNYSRNIKTFPYKELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTITTITTPNPRTGGEHPAIISRGPCNRLLLLYPGNQITILDSKTNKVLREIEVDSANEIIYMYGHNEVNTEYFIWADNRGTIGFQSYEDDSQYIVHSAKSDVEYSSGVLHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVECDQTVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYKFDKKTKNWTKDEESALCLQSDTADFTDMDVVCGDGGIAAILKTNDSFNIVALTP
The following text describes a protein:
Function:
[Matrix protein p10]: Matrix protein; [Nucleocapsid protein p14]: Nucleocapsid protein; [Capsid protein p27]: Capsid protein.
Miscellaneous:
MISCELLANEOUS: [Isoform Gag polyprotein]: Produced by conventional translation.
Subcellular Localization:
[Matrix protein p10]: Virion; [Capsid protein p27]: Virion; [Nucleocapsid protein p14]: Virion.
Domain:
[Gag polyprotein]: Late-budding domains (L domains) are short sequence motifs essential for viral particle release. They can occur individually or in close proximity within structural proteins. They interacts with sorting cellular proteins of the multivesicular body (MVB) pathway. Most of these proteins are class E vacuolar protein sorting factors belonging to ESCRT-I, ESCRT-II or ESCRT-III complexes. Phosphorylated protein pp24 and phosphorylated protein pp18 contains two L domains: a PTAP/PSAP motif which interacts with the UEV domain of TSG101, and a PPXY motif which binds to the WW domains of the ubiquitin ligase NEDD4. Both motifs contribute to viral release. The PSAP motif acts as an additional L domain and promotes the efficient release of the virions but requires an intact PPPY motif to perform its function.
Sequence:
MGQELSQHERYVEQLKQALKTRGVKVKYADLLKFFDFVKDTCPWFPQEGTIDIKRWRRVGDCFQDYYNTFGPEKVPVTAFSYWNLIKELIDKKEVNPQVMAAVAQTEEILKSNSQTDLTKTSQNPDLDLISLDSDDEGAKSSSLQDKGLSSTKKPKRFPVLLTAQTSKDPEDPNPSEVDWDGLEDEAAKYHNPDWPPFLTRPPPYNKATPSAPTVMAVVNPKEELKEKIAQLEEQIKLEELHQALISKLQKLKTGNETVTHPDTAGGLSRTPHWPGQHIPKGKCCASREKEEQIPKDIFPVTETVDGQGQAWRHHNGFDFAVIKELKTAASQYGATAPYTLAIVESVADNWLTPTDWNTLVRAVLSGGDHLLWKSEFFENCRDTAKRNQQAGNGWDFDMLTGSGNYSSTDAQMQYDPGLFAQIQAAATKAWRKLPVKGDPGASLTGVKQGPDEPFADFVHRLITTAGRIFGSAEAGVDYVKQLAYENANPACQAAIRPYRKKTDLTGYIRLCSDIGPSYQQGLAMAAAFSGQTVKDFLNNKNKEKGGCCFKCGKKGHFAKNCHEHAHNNAEPKVPGLCPRCKRGKHWANECKSKTDNQGNPIPPHQGNGWRGQPQAPKQAYGAVSFVPANKNNPFQSLPEPPQEVQDWTSVPPPTQY
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
METPSQPEFDRDNLNEDIVRMRSLWVNELNAPEILQYNDEMVSEMLEQIRNQQEYVDSVYEDRTQLTEEKSFINKLYQMEIDRLRYMVSSYLRTRLRKIEKFAVHILGDAVLTQRLSMKERHFAQQFVMLLESHMNDLALGKFAEEHRSIAAKGMGKSVDVLLFERVAGPAQCFLVLTFVWMPVCWRCMSVPEPNLDTFVFCEAKDEVGGVQCDDKGDDFVQMHPVDRYVLRYRSVQSHVEAGGVELI
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MSMRNNKRRALASAGAASKQSAVADAVLDVANRKGVRCCVECGATSTPQWREGPMGPKTLCNACGVRRQRLIRKQQAAVAGVTPTAPVAAVQARRRLATRRRPGASASLIADEDVFAPAGAGSVSEQSSDEAEMTVMGWRTTAAEVPRPQRGQHSAATGTDVEDSCNEEETAAYDLLFFAGFDCGDYGYSAPSGPSHGHNTRRQAAPQRRSDDFYYYEEQDHEGEHGVAAGEHERLPMSAPALQQVSSIKRRRVLAAPPKVHIRPGRSAMTSFPSSSAEHEAAAVPAVSNMSSLPAAAGPAPASSSDAATAELLPAAPAVLPSSAMLALQLPLLPLALPALSLPGAVVAGGASPADLEMIAALHAEFQRACMQMQQAVAAAEAVGAVAAERRDAADAAHAVAAVASQRLADGAKVVAALPEVRDVLAELHTGPVAMAVAPPL
The following text describes a protein:
Function:
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTVTGAAGIGLATLAADGSVLDTWFPAPELTESGTSATSRLAVSDVPVELAALIGRDDDRRTETIAVRTVIGSLDDVAADPYDAYLRLHLLSHRLVAPHGLNAGGLFGVLTNVVWTNHGPCAIDGFEAVRARLRRRGPVTVYGVDKFPRMVDYVVPTGVRIADADRVRLGAHLAPGTTVMHEGFVNYNAGTLGASMVEGRISAGVVVGDGSDVGGGASIMGTLSGGGTHVISIGKRCLLGANSGLGISLGDDCVVEAGLYVTAGTRVTMPDSNSVKARELSGSSNLLFRRNSVSGAVEVLARDGQGIALNEDLHAN
The following text describes a protein:
Function:
Cell surface beta-glucosidase involved in cell wall biogenesis,.
Subcellular Localization:
Secreted.
Sequence:
MPSKIEKICLLLLGFTAASNVNAYSHRRAGDTLHHRHKHEKHNDLTDSSYEPLTLSYNDTQIQQLQRRDTVQCAFPYGDKMVAVTPDEGNAGWAMSPDQYCTAGTWCPYACEPGYLMGQWDPNATSYTYPESMYGGLYCNSDGVAVKPFPSKDYCYPGVGDLSVVDQTGDGIAFCQTVLPGNEAMLIPTWVAPDSEQVLAVPDISYWDETAAHYYVNPPGVSTTDGCVWGTSANPYGNWAPYVAGANMDENNITYVKLGANPIYLDDSYWSTVKPTYGLALECEGDTCSGLPCYVDPRENGVQGCPEGSPIGAGGACFCVVGFQQGTTAKIVVVDYSEEMASSSSSASATATSSAESSIATSPITSSSNVVSSISTSSMDSSAVSSYSVVQSSLASIISNAYIATSKSGLNSGVSTLLASPTSSSTFVTSLLRRSSIDGSASSSSASLAVPTVSSSTTGSLHYKTTTTVWVTEVFTRYLGDDSTPVTSSSIFSTATEATDTSVQTSSAIYDSSSTSNIQSSSSVYASSTGALSSNSLSSSTSSVSTSYIPNASSSVYASSTEALSSNSLSSSTSSASTSYIPSASSSYEVASNSSDYYSQTVSSITASGTTSSTSEIVSTPASNSNTGSLNGTSSFNVNSVGPSSSQTTPTSSSSITGSQSLKETSSPAYVSSTVSYTSSSVDSSSTYNSTGSSSSDSQSFSGTTYSDPTTTITSEVSSILSSPTSMQSSVSRPQSSGDASGFNTIFTSISQSSDGETSGYTISSNSSQNSASEPQTAFTSSSSSATPTITQSSISTSVSSQSSMNSSYSSPISSNSVTSSTSIISSIASSSYTSIPSISSIASSFFDASGFTSIYNGTKAGFSSSFALASNSESGASDVLSSTIAKPTFKFSTSNSGSTSYSIPSSSSRNEGTTSYSSNITVTSSTLKPSLTSSVSTASSYIASSASSNTLSTEPKTFSSSSTLSESISSINTNSLTVKPESSLSSSTTSGLTSSSSTIPSSTRSESNSESASTSSASKRSSSSTSLVQSNPVKTVVSLESYKFTTSKISLVKNPTKTYTVTDVETNVVVQTHTVSYVEHSTSYTWVHTTLYEYADVEASTKSTSEPSAKSKRNAVSTFETVFLKSKSSA
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPNWLNDHIIGFAFEYFASSQFHDCSDHVCFISPEVTQFIKCTSSPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSIHAKQVAEKLKAFLGSKGDKLVFVEEKAPAQQNSYDCGMYVICNTEALCQNLFRRQPESPLQLLTPTYITKKRGEWKDLIARLAKKNRSSY
The following text describes a protein:
Function:
Transcription factor (By similarity). Required for D-type inhibitory GABAergic motor neuron synaptic remodeling, acting via degenerin unc-8-dependent and -independent mechanisms. Regulates expression of genes involved in synaptic remodeling, including negative modulation of immunoglobulin domain-containing protein oig-1 and positive modulation of unc-8.
Subcellular Localization:
Nucleus.
Sequence:
MIPIANQVKMEEPTTPQTTTPAPPTSAPDALRGILPPNLLGQFHFHPAMAQVLAAQAQAAAAAQQATLAGFPGVPMFPHGIPADLKPEMLLGGGPGPMPMFFSDAHRLYHPYGLDGIKKRNATREATAPLKDWLHSHRKNPYPSKADKVMLAVGTGMTLTQVSTWFANARRRLKKENKMTWSPQNRRGDGCDDDEDDDDDDMNRPSSSTSINSERKGESLFGKPHLASPTPSGGSGGSDELTTPKKELVSPIPNDDSESPKRKPKMWSIADVTSDDDSSKKDSPPSSDENLLTGSLFQNAMKKQMEVMARLDPTLFRHTMHPFMFQLLAQQAAQGQQLALLAPQTTPPNEAGLNSQAETSTPSPASSPTSSPRSHQE
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPLPLGDPLALAVSPQLGYIRITAMPRWLQLPGMSALGILYSLTRVFGLMATANWSPRGIKRVRQSLYLRIHGCVMLIFVGCFSPFAFWCIFQRMAFLRQNRILLMIGFNRYVLLLVCAFMTLWIHCFKQAEIIGCLNRLLKCRRRLRRLMHTRKLKDSMDCLATKGHLLEVVVLLSSYLLSMAQPIQILKDDPEVRRNFMYACSLVFVSVCQAILQLSLGMYTMAILFLGHLVRHSNLLLAKILADAEHIFESSQKAGFWPNRQELYKGQQKWLALELWRLLHVHHQLLKLHRSICSLCAVQAVCFLGFVPLECTIHLFFTYFMKYSKFILRKYGRSFPLNYFAIAFLVGLFTNLLLVILPTYYSERRFNCTREIIKGGGLAFPSRITVKQLRHTMHFYGLYLKNVEHVFAVSACGLFKLNNAILFCIVGAILEYLMILIQFDKVLNK
The following text describes a protein:
Function:
Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MCACMWIKPPEAAEGAGTQLGKRGGVPGAPAALLVCPYGLRPLPFPGAGARMAAGTRPAAAPRSRATMAQWKKKKGLRKRRGAASQSHSSDSEDGEFEVQAEDDARAQKLGPGRPLPTFPTSECTSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPMILDGKDVVAMARTGSGKTACFLIPMFERLKTHSAQTGARALILSPTRELALQTMKFTKELGKFTGLKTALILGGDKMEDQFAALHENPDIIIATPGRLVHVAVEMNLKLQSVEYVVFDEADRLFEMGFAEQLQEIIGRLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDSKLNEQLKTSFFLVREDAKAAVLLHLLRNVVRPQDQTVVFVATKHHAEYLSELLATQGVSCAHIYSALDQTARKINLARFTHGKCSALIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEVPYLLDLHLFLGRALTLARPPEEPSGTEGGDGVLGRVPQGVVDDEDCGLRTSLEASLELRGLSRVANNAQQQYVRSRPAPSPESIKRAKELDLAGLGLHPLFSSRFQQEELQRLRLVDSIRNYRSRATIFEINASSRDLSSQVMRAKREKDRKAIASFQQGRQERQEGPAGPTPSLPAPQEEQPEKEEVAGESVEDVFTEVVGRKRQQPGPQRGAKRRREEARQRDQAFYIPYRPKDFDSERGLSIGGDGGAFEQQVAGAALDLMGDEAQSLTRGRQQLRWDRKKKRFVGQSGQEDKKKIKTESGRYISSSYKRDLYQKWKQKQKIDDRDSEEEGTFDRRGPERRGGKRGRGQAGASQPRTPGTPAGRVLSELKTKQQILKQRRRAQKMRFLQRGGLKQLSARNRRRAQELQQGAFGRGAPSKKGKMRKRM
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MQCYASLACLTGLGLVLVPLAAAQGSAPELKTPSDQYMKDEFRRHKTVGSEEAQCFLQEWEVYAAVLWQQANENRQNSTEKACFGTTLPEEKLSDFRDEQTGQLQELMQEASKPNRQFSGTELLPKYSGGAGDTPGPGEKWSSHCREGLALKKKKKR
The following text describes a protein:
Function:
Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.
Sequence:
MRFSYIICLIFVSFYFASVCLGSFLDKPVLDDNLINSINNNKKSSWTAHRNKNFEGKTFGDIIGMMGTKKTAAPFKLTENGEELKGSIPTSFDSRVQWPDCIHPILNQEQCGSCWAFSSSEVLSDRLCIASNNKTNPGALSPQTLVACDVYGNDGCSGGIPQLAWEYMELKGLPTDSCVPYTAGNGTVYSCQRSCSDSEDYSLYRAKPFTLKTCSSVQCIQENILAYGPIVGTMEVYEDFMSYSSGVYVMTPGSSLLGGHAIKIVGWGFDQTSQLNYWIVANSWGADWGQQGFFFISMETCSISSDASAAEARV
The following text describes a protein:
Function:
Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis. Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene nuclei. Required for the removal of the cohesin component scc-1 from mitotic chromosomes.
Subcellular Localization:
Nucleus. Note=Expressed in mitotic and meiotic nuclei, with low expression in nuclei during the early meiotic prophase stages leptotene and zygotene, and increased expression in late pachytene nuclei which then continues to remain high in diplotene and diakinesis oocytes.
Sequence:
MSSDANSDDPFSKPIVRKRFQATLAQQGIEDDQLPSVRSSDSPDVPDTPDVPVNQLSSPPLSLPETLSEGNAETLQNLSDDSEPEMLSQSSTSSLNRRMEDSAIDPSRGTRKSQSRGFDYDPAGERTTAPVQKKKKDEIDMGGAKFFPKQEKKHVYTHKWTTEEDDEDEKTISSSSNRYSSRPNQPAVSARPRQPVYATTSTYSKPLASGYGSRVRHIKEANELRESGEYDDFKQDLVYILSSLQSSDASMKVKCLSAISLAKKCVSPDFRQFIKSENMTKSIVKALMDSPEDDLFALAASTVLYLLTRDFNSIKIDFPSLRLVSQLLRIEKFEQRPEDKDKVVNMVWEVFNSYIEKQEVGGQKVSFDMRKESLTPSSLIIEALVFICSRSVNDDNLKSELLNLGILQFVVAKIETNVNLIADNADDTYSILILNRCFRILESSSVFHKKNQAFLISHRSNILISSLAKFLQVILDRVHQLAEEEVKKYISCLALMCRLLINISHDNELCCSKLGQIEGFLPNAITTFTYLAPKFGKENSYDINVMMTSLLTNLVERCNANRKVLIAQTVKMVIPGHDVEEVPALEAITRLFVYHESQAQIVDADLDRELAFDEGGCGDEEEEEEGGDESSDEDGVRKDGRLDRNKMDRMDQVDVVHALQQVMNKASAHMEGSVIASYHALLVGFVLQQNEDHLDEVRKHLPGKNFQNMISQLKRLYDFTKATMAKRVESNSGFRAIERVIEYLERLE
The following text describes a protein:
Function:
Involved in nonsense-mediated decay of mRNAs containing premature stop codons. It interacts, via its C-terminus, with NAM7/UPF1. Could be involved in determining the efficiency of translational termination or reinitiation or factors involved in the initial assembly of an initiation- and termination-competent mRNP.
Subcellular Localization:
Cytoplasm.
Sequence:
MSREEQIKKLNQYLDNRELAFRAKDGDKNIFHTESQLDSSLKKNTAFMKRCKSSLTSENYDSFIKEIKTLSLKKFIPEITAAIVEGMMKCKATKDILSSVKIVWALNLRFSTAFTGPMLANLYCALYPNPGYSLCHESYFELKQNENEVSEKDRSSHLLKVRPLLRFLIEFWLNGVVGTPEDFVSYLPSTDSNDKKFRKPWFEEQNLKKPLVVLLFNDLMDTRFGFLLLPVLTSLVRTFSCELFTTEDFEDKETLELVNRLNPVVWRTYLRKSLNSYVDKLEVYCQKRKSLFEELNKQYQEQSIIRADPNNEKFQRLANFSKSIESEFSSYASLSEVLNRKASEDLLELNFMEKASSGTNSVFNASGERSESANVETAQVWDDREQYFFYEVFPNFNEGSIAEMKSSIYESSQEGIRSSSENNKKEDDLKDSTGDLNTTQVSSRVDNFLLKLPSMVSLELTNEMALEFYDLNTKASRNRLIKALCTIPRTSSFLVPYYVRLARILSQLSSEFSTSLVDHARHSFKRMIHRKAKHEYDTRLLIVRYISELTKFQLMPFHMVFECYKLCINEFTPFDLEVLALLLESCGRFLLRYPETKLQMQSFLEAIQKKKLASALASQDQLVLENALHFVNPPKRGIIVSKKKSLKEEFLYDLIQIRLKDDNVFPTLLLLRKFDWKDDYQILYNTIMEVWNIKYNSLNALARLLSALYKFHPEFCIHVIDDTLESLFSAVNNSDHVEKQKRLAQARFISELCVIHMLDVRAITNFLFHLLPLEKFESFLTMKASTLTNINNDMFRLRLIVVVLQTCGPSIIRSKTKKTMLTYLLAYQCYFLIQPEMPLDMLYEFEDVIGYVRPSMKVYMHYEEARNALTERLQAISDDWEEDDTRPVFQGANDGDISSNEESVYLPEDISDESETDEESSGLEESDLLDSEDEDIDNEMQLSRELDEEFERLTNESLLTRMHEKNPGFDVPLPLRASSLGSPYVTRNEESASESSHVMFTLLTKRGNKQRSQYLEIPSHSSLVRSTKNQQTEEIMERKRVKEMVLNFE
The following text describes a protein:
Function:
2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate (Probable).
Miscellaneous:
MISCELLANEOUS: The mitochondrial 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes (OGDHC and OADHC, respectively) share their E2 (DLST) and E3 (dihydrolipoyl dehydrogenase or DLD) components, but the E1 component is specific to each complex (E1o and E1a, respectively).
Subcellular Localization:
Mitochondrion.
Sequence:
MASATAAAARRGLGRALPLFWRGYQTERGVYGYRPRKPESREPQGALERPPVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGIGTVHLHQHEDILAKTFA
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Subcellular Localization:
Nucleus.
Sequence:
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWSDLALQYLHENIPPTGN
The following text describes a protein:
Function:
Transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MASVEDATKVQEMLDALKAEYNALAHHSFASKARGNDYESSMIQSQIQEIEAFRKTVDDMYEKQKSIRETYEKDINKLKRELEELGVEANTASYRNRGERSELAASNNQVTHIDQEHPSQTKSTSQPPSNHLPAFQQIPPIHQSAYPQNNVAEVLMPPIPPSVEASSGQNFNQGIASQNPAISTSNLPSTTPLYIPPVNYGANQVSQQPNPQLPGVSNYYNPSATSKPAVNVQPPRIPTKATPSAEPSMTASANAGSISQAGPDGEYQGREQIAPVSDTEAARKTTSQSWYVTYNPACKRVFNINLVHTLEHPSVVCCVKFSNNGKYLATGCNQAANVFDVQTGKKLFTLHEESPDPSRDLYVRTIAFSPDGKYLVTGTEDRQIKLWDLSTQKVRYVFSGHEQDIYSLDFSHNGRFIVSGSGDRTARLWDVETGQCILKLEIENGVTAIAISPNDQFIAVGSLDQIIRVWSVSGTLVERLEGHKESVYSIAFSPDSSILLSGSLDKTIKVWELQATRSVGLSAIKPEGICKATYTGHTDFVLSVAVSPDSRWGLSGSKDRSMQFWDLQTGQSYLTCQGHKNSVISVCFSPDGRQFASGSGDLRARIWSIDPASP
The following text describes a protein:
Function:
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. Also, involved in the degradation of oxidized and glycated proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MERQVRARGRGRGPPRGPPAPGSLRSRPHPSVPAQVLAEPTEALAVYRRLSRYPALAAASVGPEVVTQYGGRYCPVQTEWLQRDLERMEAVRFCRQYLVFHDSGSVLFAGPAGTCTETKGELLSRESPSGLMKALLRKISNNCTGEDKQFLEVWGKNSKLRTVNLTALEKHGPVYEDDCFGCLSWSHSETHILYVAEKKRSKTESFFQAKPAEFSDETPRMKKEDSTVKGDQFVFHEDWGESLGSKSVPVLCVLDIDSGNISVLEGIPGHISPGQAIWAPRDTGVVFVGWWHEPFRLGVRFCSNRRSALFYLNLTSGKCEPLTDDTKASWSPRLSPDQCHIVYLRYTTLGPHHQCSQLCLLDWYSRLTTVIVDVVPRQSKGYFSGIYCNLLPLSCWSDDSQRVVFDSGNRSRQDLFSVDMLTGSVIPLTSGFPAASWKLFTVQRDLLVAQFSTPNCPPSLKVGFLPPPGKEQTICWMPLEDAEPLIEIMWGIRALQPPPEQENPRYAGLDFEAILLEPNIPTGRKKIPLVVMPHGGPHSSFVAGWMLFPAVLCKMGFAVLLVNYRGSSGFGQDSIFSLPGNVGDQDVKDVQFAVEQLLLEEQFDSGRVALMGGSHGGFLSCHLIGQYPEVYKACIARNPVINIASLSGSTDIPDWCLVEAGFPYRAEYLHDPAIWLEMLKKSPVCYISQVKTPVLLILGQEDKRVPCKQGVAYYRALKARNVPVRVLLYPKSSHSLSEVEVESDSFMNTVVWLCKHLGTC
The following text describes a protein:
Function:
Catalyzes the attachment of glycine to tRNA(Gly).
Subcellular Localization:
Cytoplasm.
Sequence:
MEKLIAHLKSQGFIFQGSEIYGGLANSWDYGPLGVEVKNKLKQAWWNHFVRKNPYNIGLDSSIILNSSVWKASGHIDGFNDPLIDCKKCNSRWRADKLIEEFNSEINAGVMTENQMEEFIREQNIKCPKCQACDFTQIRKFALMFKTNQGVLEDESSSVYLRPETAQGIFINFKNAQRSLRKKLPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFFNPSDEKDWFSYWLNEVETFLQDKIQINKENYRVRSHEKDELAHYSTATSDIEFKFPFGWGELWGVAHRGNFDLNAHQEASKQDLTYLDPTTNQKVLPHVIEPSVGVERMMLAILWQAYHEEDLGEGNSRIVMKLPYNLAPYQIAVMPLQKQQNDQAQALYSNLLNNFDVTYDETGNVGKRYRRQDAIGTPFVITVDFDTPETNSVTVRERDSMEQVRINLDELEAYLKAKF
The following text describes a protein:
Function:
May act as a transcriptional regulator of a number of proteins of the circadian clock.
Sequence:
MESPLLAYPQSGGEQRERTRLCSSSGGGRRKREFILDEKKDNSYWEKRRKNNEAAKRSREKRRFQDLVLEGKVQALDEENGRLRSELLQLKLRFGLISATSFLETGQGLGGRASSDNGTLPCRGGNGAYSTAYLGMNSDSSEADSGGGAAIDGYSPRGSFSDLSDHSSRDSPGPSTYGDERSTDTEFAHLCPSENPSAAILATQRGGVILYRVGGLNVDPQQRQDSGLPSFATLTSKEHKCSPPQIRPSIFAHTDPIPSHLQHLVKAGEDGITEGLDSPKSVAYEYQSEESGSEEGVIGYCPPECPPHHDSFPGVKLPHKLRLKCRPHGQET
The following text describes a protein:
Function:
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Sequence:
MRMRSVTIEAFRVEKWNSWSKVYLTNGKRKANEGPEGDNNQGTKTTANRRIIPNYATNYQKCTEDVARRFMAVGFIWKIKKIITFEQYYYSDESKTDNSVKDTLIHGIGRSGDIAAIQPKAASSRDVANVGKKVILDIIRLAGVQTASSCFLVPMAIGMSLTLCFLTLWHQRPKPNYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELHTDLNAVESKITGIGAENILCVHSTTSCFAPRLVVNLCYQHNSTISCKLYQRDVYGCEQSSSAVTQLGSMLFTRQVPGASSCLDDEKLHK
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
MKLIKMTIVVLTIIIIFEFLIVANSQNQLKVGFYNQVCPNAESVVTNIVRDAAKSDHRIPPGLLRLHFHDCFVEGCDGSILIDKGNTSEKGAFEHQGLTGFNIIEDAKAKLESICPGVVSCADIVAMAARDAVAFSHGPVYHVETGRKDGLVSNIDLANRMPDVRDSIQLLKQKFIEKGLNEKDLVILSGNFVRFIFVLCFGKITKIVMLTKQFSKTVKEI
The following text describes a protein:
Function:
Specifically methylates the N7 position of a guanine in 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MLEFSSEVSLLDSVKNILLEYGLRFQEPQIEKVDKYIEELLGVPYNLTAHRDLDSAVHKNVVEILLPLKEELKGTLLDVGSGNGVPGLILAIFFSKLKVVLLDSREKSVNFLRGVIEKLDLENVSVVKERAENFSKERREEFDYVTARAVARLNVLVEICTPALKTGGKLLFYKGPSYIEELKEAQRAMKELKVELEKVREYSLKTGERRALLILRKYESSPEKYPRRVGVPFKRPLL
The following text describes a protein:
Function:
Transcription factor that promotes photomorphogenesis in light. Acts downstream of the light receptor network and directly affects transcription of light-induced genes. Specifically involved in the blue light specific pathway, suggesting that it participates in transmission of cryptochromes (CRY1 and CRY2) signals to downstream responses. In darkness, its degradation prevents the activation of light-induced genes (Probable). Involved in responses to cold conditions probably by modulating the expression of several genes and triggering anthocyanin biosynthesis. Acts coordinately with SPL7 to regulate the microRNA miR408 and its target genes in response to changes in light and copper conditions. Regulates the abscisic acid (ABA) signaling pathway. Also involved in root gravitropism. Involved in the repression of hypocotyl cell elongation to promote photomorphogenesis. Recruits the histone deacetylase HDA15 to the promoters of a subset of cell wall organization and auxin signaling-related genes. HDA15 represses their transcription by decreasing the levels of histone H4 acetylation in a light-dependent manner.
Subcellular Localization:
Nucleus.
Sequence:
MQEQATSSLAASSLPSSSERSSSSAPHLEIKEGIESDEEIRRVPEFGGEAVGKETSGRESGSATGQERTQATVGESQRKRGRTPAEKENKRLKRLLRNRVSAQQARERKKAYLSELENRVKDLENKNSELEERLSTLQNENQMLRHILKNTTGNKRGGGGGSNADASL
The following text describes a protein:
Function:
JanA and janB regulate somatic sex differentiation.
Sequence:
MLKAAAAALYRKNSNFLQGLRLLHKMSDQDLAKIPLVDIDEEGIFKYILIRVTGKETADGTEPSKLVVRGYADCEWHADIYERTQGTIKGTGLDTECLGGGRIEHNPEKKYLKVYGHSTGYGKADHAESKRVLLTKYKNYEIETSDEGY
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs.
Sequence:
METPLDVLSRAASLVHADDEKREAALRGEPRMQTLPVASALSSHRTGPPPISPSKRKFSMEPGDEDLDCDNDHVSKMSRIFSPHLNKTANGDCRKDPRERSRSPIERAVAPTMSLHGSHLYTSLPSLGLEQPLALTKNSLDASRPAGLSPTLTPGERQQNRPSVITCASAGARNCNLSHCPIAHSGCAAPGPASYRRPPSAATTCDPVVEEHFRRSLGKNYKEPEPAPNSVSITGSVDDHFAKALGDTWLQIKAAKDGASSSPESASRRGQSASPSAHMVSHSHSPSVVS