lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
Subcellular Localization:
Nucleus.
Sequence:
MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADCTGPCPLEIESIKIESLLYRIASFLQLKNYGQADEDCRHVLGEGLAKGDGAFQAVLCCMQLKGKLQPVSSILAKSLTGESLNGMVTKDLTRLKTLLTETETATSNVLSGYHVEDIDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVEVEHNPDLSVTVNTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQSRLHDLLYIEEIAQYKEVSKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKEKLVQTQGTKEKVYEATIEEKTKEYIFLRISRECCEELNLRPDHDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDITMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENNSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRVQHTGNATKLQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVSIGQPQNQHQEKDQHEQSRNGKSDTNNPGPEINKIRTPEKKPTESKQIDLESNPQNRSPESRPGVVYPNTKFHRKDNLNPRHINLPLPAPPAQYAIPSRHFHPLPQLPRPPFPIPQQHALLNQQQNNLPEQPNQMPPQPNQVVQQQNPLNQLTQQPPPQLSPAYQASPNSAFFNNAVSHRPQSPPAEPGVPEQQPPPMLQEGHSPLRAIAQPGPLLPSHLNNFADENPPGLPIGEALDRMHGSVALETLRQQQVRLQQWNEHHAYLSQGSIPYPHHHHPHPHLQHLPQPPIGLHQPPVRADWKLPSSAEEEAETTDSRFQDLIRELSNRDQSETRELAEMPPPQSRLLQYRQIQTRSPPAVPSPPSSTDHSSHFSNFNDSSRDVEVANNPAFPQRLPPQMFSSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHNNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTIKPPEDHLKPENLEVSSSFNYNVLQHLGQFPPLMPNKQIAESVNSSSQQSSGGSKPTMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHSHRRYTRSRSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYEDYDYRYRRRSPSPYYSRYRSRSRSRSYSPRRY
The following text describes a protein:
Function:
Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Contains a slightly degenerated ERF-associated amphiphilic repression (EAR) motif, which may be involved in the activity of transcriptional repression.
Sequence:
MAPRQANGRSIAVSEGGGGKTMTMTTMRKEVHFRGVRKRPWGRYAAEIRDPGKKTRVWLGTFDTAEEAARAYDTAAREFRGSKAKTNFPLPGESTTVNDGGENDSYVNRTTVTTAREMTRQRFPFACHRERKVVGGYASAGFFFDPSRAASLRAELSRVCPVRFDPVNIELSIGIRETVKVEPRRELNLDLNLAPPVVDV
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MIYLEDIIELIEDVPDELQRRGGLIQDWERQASEYKREADKLTARLHNDNTLRDEDKAHIYRKIGEMLDRARDVSEKKYDMAHKCHQLLQALSDRVSDWSYHCKLELEVDAPGTTQGIESNFLNETMMVAAAAVNSRTAGSAAPPSSAPPQPPAFRVPDEKPASRRDRVGSSSMSRESTPMFGVGTGAGERRAEAGGGRAAVYANNSRTRDSSLSSSRSGSVTPYDPQAAAIATSTTTQQQQRKRKRDRERERAARKSECSEVPVLKDPMSSYMRKKKEREREERKLREAHRLASQRQAAAAAAAAQLPPHAADAAAAAARAAASRIALKRGNVHANRERTSQQRVIKPEPLDDGYESQLQQQQPARRAGPGRPPGSRTMKCGMSDADDDDLLKFLQGEMPGGIPPQDIHVAMGLEDENIFDFSTLGKDLGNEIGKIQSDRDPSPPPGNYYGTLNATTKASAPGPSRYNNSSDPRFAPTKADLKRQQVRLTARAEIHAIDLDQKERKRRQKEEEMERGEYGRRESRELSLGDGEYGGGAGEGNEEDSDTNLYCYCNMPSEGEMVGCDGKRCPYGGWFHLACLDMLTAPASDTWYCPVCQSRRKGR
The following text describes a protein:
Function:
Has a role in the septation initiation network (SIN) required for cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the SPB prior to cytokinesis and leaves once septation is complete.
Sequence:
MEDLLNNAKQHLCMRNPKLIRIGLRQVESIVYHVAKPSHDDKIPREIFLKLQDSPLYNSTTPCIYALDSLLEYQQNEEAYEKNFQFIQKLIDDLLHVIEGLVLIHPKSQTLFEDKATLRLFIHLLQPSQPSMLQVAAMKTLVCIMADRPLAIRLFEQINGLQQICVVFKHKQTSQDTRFQILEFFYFYLSPEPYSIDVIAYRKTRTEKQAYLSKYLSNVQGLRDDLDKFQPFGKLDETFD
The following text describes a protein:
Function:
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP.
Sequence:
MVDRVVPVILIQPRSSHSLGHSCCGFWFLVFLQDSQEHDSTSEGMDDSNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGTIRLLMRRDKTLKICANHYITPLMELKPNAGSDRAWVWNTHADFADESPKPELLAIRFLNAENAQKFKAKFEECKKELKNQENKVKNEEPKIEPKEESVEPKEEPKEESKEEKAGIVKERSSDQMAEKLEALSVKDGDPESNQEIQVQEAALETQEAQESQEDQEEQEPEAQDKDTELQ
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Sequence:
MASKALLLAVAVAVAAGCADATDHIVGANRGWNPNINYSGWSANQTFYAGDLISFRYQKGTHNVFAVNETGYDNCTMAGVTGNWTSGKDFIPLPDPGTYFFICGNGFCQAGMKVAITVAPGIFDLGPQIYPPPAPGADNPSASFTAGAWPAAAAVVTALGAAAIIAL
The following text describes a protein:
Function:
Ser/Thr protein kinase mediating a primary step for phototropin signaling in guard cells. Essential for stomatal opening.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MARNKLEFPLDAEAYEIICKIGVGVSASVYKAICIPMNSMVVAIKAIDLDQSRADFDSLRRETKTMSLLSHPNILNAYCSFTVDRCLWVVMPFMSCGSLHSIVSSSFPSGLPENCISVFLKETLNAISYLHDQGHLHRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSSLRLTDIAGTPYWMAPEVVHSHTGYGFKADIWSFGITALELAHGRPPLSHLPPLKSLLMKITKRFHFSDYEINTSGSSKKGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPFFKNCKGLDFVVKNVLHSLSNAEQMFMESQILIKSVGDDDEEEEEEDEEIVKNRRISGWNFREDDLQLSPVFPATESDSSESSPREEDQSKDKKEDDNVTITGYELGLGLSNEEAKNQEGEVVGFDKDLVLEKLKVLKKSLEHQRARVSIIIEALSGDKEEKSREEELLEMVEKLKIELETEKLKTLRADKDSVLG
The following text describes a protein:
Function:
Transcription factor that binds to the motif 5'-GTAACNT-3' in the promoter of target genes (e.g. DD11 and DD18) and promotes their expression within synergid cells (e.g. in the filiform apparatus) in ovules. Required for the formation of the filiform apparatus during synergid cell differentiation in the female gametophyte. Involved in pollen tube guidance to the micropyle.
Subcellular Localization:
Nucleus. Note=Localized to the nuclei of the synergid cells.
Sequence:
MENFVDENGFASLNQNIFTRDQEHMKEEDFPFEVVDQSKPTSFLQDFHHLDHDHQFDHHHHHGSSSSHPLLSVQTTSSCINNAPFEHCSYQENMVDFYETKPNLMNHHHFQAVENSYFTRNHHHHQEINLVDEHDDPMDLEQNNMMMMRMIPFDYPPTETFKPMNFVMPDEISCVSADNDCYRATSFNKTKPFLTRKLSSSSSSSSWKETKKSTLVKGQWTAEEDRVLIQLVEKYGLRKWSHIAQVLPGRIGKQCRERWHNHLRPDIKKETWSEEEDRVLIEFHKEIGNKWAEIAKRLPGRTENSIKNHWNATKRRQFSKRKCRSKYPRPSLLQDYIKSLNMGALMASSVPARGRRRESNNKKKDVVVAVEEKKKEEEVYGQDRIVPECVFTDDFGFNEKLLEEGCSIDSLLDDIPQPDIDAFVHGL
The following text describes a protein:
Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate). Also catalyzes the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A.
Sequence:
MLENNGSVILMEPDHLRTAVNRSMTSREGRTKNRFNPITGARLAAGVVALSADKRKVLLVSSAKKHPSWVVPKGGWEADESVQQAALREGWEEGGLVGHITRSLGSFKDKRPTDTIDRRKKYLKQLMSKSSGNDVSTNTELGAEAEKLLLPPRAECEFFEVIVERLEDNYPEMRKRRRKWMSYQEAKEALTSRKDILAALEKSSIIKEEN
The following text describes a protein:
Function:
Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. Stabilizes the 3' terminus of mRNAs and modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Necessary for accurate chromosome transmission during cell division (By similarity). Together with lsm1, recruits the deadenylase ccr4 to P-bodies.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Sequence:
MSFFGFNTTLPKENMFPNEGQLEEDGIDFEETYDDLGNQLNEAGDELNDETFGVSAGSIGRDFDFSGTTAQASAQLEDEQYQINQQNIFAKPVKPASSELPQVSRLNGASQFPSREPASTAINKLSDLQPMASIWENIVPEKPAIIPPEVASLQDRLGAQPSEKVFSLQELEEQLLNSMTAPKPPSQPAIPIVPSEMAAQVTRENISSLDPAISAASIGNVTFGQPNIPSTTTDFAGLAAPNMVHPSQAIPNPVMQPSLVPQMPYPQNGMYNPSVAPPASLVNLFQQEQLIQNQNLDEKRQKLERDHMLMAQCAGLMTRSDKSFIARIQISQLMSEDPESDDFYYRVYSIIRGRKPSEEEASHFIQTYLGPSNNRRRGRRSENPMQKLQQQLQRLVSSAKERPKATQLSLEGALGKIAVNTVRTPRQLLNVKRPTEPASSNSSLNNFSGFSTKKDVLHAIEKVYDLLLDFEQALRKASTLETTDQEQIDTWKTTLSEKLESIWKALYINESLEASSKTRPPFISIISHPKGMRLLPRLFPHLSKEQQISILKVVVYNFDSLDIVLRGTFDVNGELPLDVVSEMSSFTQFIIPPLLTIVNELDLETINNLFSQLLNRTNAVYLIQTKIGLSFLTLFISRAEILKQSGTVNQNEKEEWENTFNVMFNRVKGHFSTVFPPPNARAYADESYPWEFLAACATAASSEQHFTLVSETRDRVLDNIITSKRAPSEIAVVRISNVNLFLNAMGLDARQLSA
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 2.
Subcellular Localization:
Cytoplasm.
Sequence:
MHGAPEFLTKVKQQYLQQVDLYRFQWVSKPTDWPILFNDYAQVFLSEIVTPSAYTRAFLKSYFRFLDSIDSGHNERNEALLYTYIESLSSTYIPPVQYSLGEYDILIRESRHVLLREGTTGARTWEAGMALAEYIYQHPVQSGMRVLELGAGTGLVSILCAKMGSIVLATDGDTKVCDGVRENARLNNCDINVKKLLWGVDPPEFSDIVFASDVTYDCDLRCLATTLTQIITINPNCKIILSASLRRQETFFNFLKLIQNLYARQLEVWDSPKILYYDSPPIVFYEVSK
The following text describes a protein:
Function:
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, transcription or reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
Sequence:
MKAGPAPLPPPAAKPPPQPPAALPVQKDARWRLRGRFPRLASLPPGAPLEAASAPARSGGGGREAGGGGRGAGRESVRPGGGQPPGRRTPAGAGGGRRGAEAARGGCGEAAAEEHVRAVSGGPDPQPRPAMSKVSFKITLTSDPRLPYKVLSVPENTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC
The following text describes a protein:
Function:
Troponin I is the ATPase inhibitory subunit of troponin in the thin filament regulatory complex. Involved in the development and maintenance of muscle and nervous system. May also be involved in the cytoskeletal apparatus.
Sequence:
MADDEKKAAAPAAAPAAAAKPAAPAAAPAANGKAAPAANGKAAPAAAAAPAGPPKDPNDPKVKAEEAKKAKQAEIERKRAEVRKRMEEASKAKKAKKGFMTPERKKKLRLLLRKKAAEELKKEQERKAAERRRIIEERCGSPRNLSDASEGELQEICEEYYERMYICEGQKWDLEYEVRKKDWEINDLNAQVNDLRGKFVKPALKKVSKYENKFAKLQKKAAEFNFRNQLKVVKKKEFTLEEEEKEKKPDWSKGKPGDAKVKEEVEAEA
The following text describes a protein:
Function:
Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytosol. Nucleus.
Sequence:
MFGCLVAGRLVQTDALQVAADKFVFNLPDYENVNHVVVFMLGTVPFPAGMGGAVYFSFPDPLSGGPVWQLLGFITNDKPSAIFKISGLKAGKGGAHPFGMMAAAPSSVAQLGVSVETLDQLAQQTPVSSAAVSTVDSFMQFTVCSVHAKFEASFILNEEKWVWLTKNLRCQGNKFFYFCRFS
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids. In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFRMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKTCRGSSLIPLVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYSGEIMSEVMAQRQPVKPTYAIPIIPITNSSQFKHQDATDSKEFKVNKQDKADLIRPKRKYEKKPKVLPPSAAAPQQQSPAALPGFSAKDLNQYDFPSSDEEPLSQVLSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCLGFARRRVGRGGRVVLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTSEPNTSDRSSSKDLSQILVDIKSCRWRHFRPRTPSLPDSDSGELSSRKLHRSISRAGAAQPGAHTCSTSTQNRSSSGSAHCAFTAEQYQQHQQQLALMQQQQLAQTQQQQQANSSSSAAAQQGFVSKTLDSASAQFAASALMTSEQLLGFKVKDDVVLGLGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSSLSHQVTAASSATTQVLFGNNIRLTVPSSVPTVNSVTPINARHIPRTLSAVPPSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT
The following text describes a protein:
Function:
Plays an important role in the elongation step of protein synthesis.
Sequence:
MPTDPERAVSYAALILADDATPITPEKLQVLLIAAGIEDVEPIWTTLFAKALEGKDVKDILTEVASAAGGVVAGGKIVDGKFKENAEEKDGEKDGGDEEGSDDEDMYGDFGLFD
The following text describes a protein:
Function:
Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Hydrolyzes phospholipids as well as galactolipids. May play a role in disease resistance (By similarity).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MLTTMQRVHNKPIDSIGGFKHLVKQSNGGDGGVTATDMQEPSIETDKLSYEIFSILESKFLFGYDDDLKLMESRSRDPSPEQETASPAMVEALNGVVPGTVKNQRGKVCVLSIDSGGMRGIIPGKALAYLEHALKSKSGDPNARIADYFDVASGSGIGGIFTAMLFASSDGNRPIFKAEDTWRFLAMKGKSFYNKSPPGILNRVMKTGSGGSGGSGSKLEKAMKESFEELTLKDTLKPVLIPCYDLTSSAPFLFSRADALETDGYDFKLWEVCRATWAEPGVFEPVEMRSVDGKTRCVAVDGGLAMSNPTAAAITHVLHNKQEFPFVRGVEDLLVLSLGTGQLVDVKYDCDKVMKWKAKHWARPAVRISADGAADTVDQAVSMAFGQCRRSNYVRIQANGSSFGPCKPNIDTDASPSNVNMLVGVAEEMLKQKNAESVLFGGKKINEESNYEKLDWLAGELVLEHQRRSCRIAPTVAFKQSGDRRVDQQTIFKDIDCMF
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MIGLLEQFYKNEEIQSVINGLEDGLKEQLISGMATSSRSLLMAALYKKTKKSQLIVTHNLYQAQKVHEDLVALLGEKDVWLYPVNELIASEIGVASPELKAQRIEVLNRLAAGENGIIVAPVAGLRRFLPIKELWKQKQVEINLGQEIDLDALLHTLHHIGYERKSMVEAPGEFSLRGGILDIYPLTEELPFRIEFFDTEVDSIRLFDVDEQRSQGKKESVRFGPATEFLFSQEELKSGIQHLEEGLTKTMQKLSDDKLKTTVLETVSHEIEMLKNGQSIEQMFKYLSIFYKEPASLIDYLPEDGVVILDEISRIQETASHLETEEAEWYISLLGEGTIIQDLSFSHPFEGFLHHKKRSFVYLTLFLRHIAHTHPQNIVNVTCKTMQDFHGQMNLLKTEIDRWNEGHFTTVVLGTDDERVKKLQHILSDYDIEADIVEGTDILLPGRLQIAVGDLHAGFEMPMQKLVVITEKELFHKKVKKSQRKQKLSNAERIKSYSELKVGDYVVHVNHGIGKFLGIETLEINGVHKDYLNIKYQGNDKLYVPIEQIDQVQKYVGSEGKDPKVYKLGGNDWKKVKTKVEKSVQDIADDLIKLYAEREASKGYAYTPDTAEQQEFESSFPYQETEDQLRSIDEIKKDMERGRPMDRLLCGDVGYGKTEVAIRAAFKAIMDEKQVAILVPTTILAQQHYETIRERFQDYPINIGLLSRFRTRKQQNETIKGLKDGTVDIVIGTHRILSKDVTYKDLGLLIIDEEQRFGVTHKEKIKQLKANVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVVEYNPALMREAIERELARGGQVYFLYNRVEDIERKADEISMLVPDARVTYAHGKMNESELESVMLSFLEGQHDVLVSTTIIETGVDIPNVNTLIVFDADRMGLSQLYQLRGRVGRSNRVAYAYFAYKRDKVLSEVAEKRLQAIKEFTELGSGFKIAMRDLSIRGAGNLLGAEQHGFIDSVGFDLYSQMLKDAIEQRRGTDGAENIVNVEIDLEVDAYLPDAYISDSKQKIMMYKQFRGVSAIEDIEELQEEMIDRFGDYPQEVGYLLQIANIKVLAMKEQIELIKQNKFEVTFLFSEQASQNIDGGKLFMLGNSFGRMIGLGMEGSQLKIVMKTNDLETSKWLTIAENLLKGLPDVKKEVINA
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Domain:
The N-terminal domain interacts with RNAP and the C-terminal domain binds either to Rho or to RpsJ (NusE). Contains an additional, species-specific domain inserted into the N-terminal domain. The N-terminal and C-terminal domains can interact and form a closed conformation.
Sequence:
MKKKWYIVLTMSGYEEKVKENIEKKVEATGIKNLVGRIVIPEEVVLDATSPSERLILSPKAKLHVNNGKDVNKGDLIAEEPPIYARRSGVIVDVKNVRKIVVETIDRKYTKTYYIPESAGIEPGLRVGTKVKQGLPLSKNEEYICELDGKIVEIERMKKVVVQTPDGEQDVYYIPLDVFDRDRIKKGKEVKQGEMLAEARKFFAKVSGRVEVVDYSTRKEIRIYKTKRRKLFPGYVFVEMIMNDEAYNFVRSVPYVMGFVSSGGQPVPVKDREMRPILRLAGLEEYEEKKKPVKVELGFKVGDMVKIISGPFEDFAGVIKEIDPERQELKVNVTIFGRETPVVLHVSEVEKIE
The following text describes a protein:
Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
Subcellular Localization:
Membrane; Single-pass membrane protein. Membrane; Single-pass type II membrane protein.
Sequence:
MNNVLQKFSLKEIQKKAFIWIVLASLIFLFYLSLQATNTGFSEKPLTNKASSTKKSNTVSSANNVKQLGVVIPSTTLNNIGQHDLSATKVLPMATIQTNMSIAVDFDINSTDVMVVLHMQKTSGSTFGRHLVRDLEPPFTCEYVQKKMSLCPRPNGQETWLFSRFSRGWRCGVHAGWTSLTECVPLLFHDPKLERRYFYITVLREPVARFLSEWGHVRRAATWDQHKFLCNKVQTPQKVCWGEALDWRNASLEEFINCDINFGRNRQTRMLADLKLVNCSAFGDEEHDRIMLKSAKHNLMSMPFFGLAERQVDSQALFEQTFGIKFTKQFVDKSETHVSNIVLDEEVSDKIRKLNHLDVQLYKYAKEIFARRYERIRKDKQK
The following text describes a protein:
Function:
Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT).
Sequence:
MIDSLNHLPRPDAGADTLAERFADLAPPLNARQAALESARCLYCYDAPCVNACPTEIDIPGFIRSIAQENVQGAAQKILSANILGGSCARVCPTEILCQRACVRNNAQECAPVLIGQLQRYALDHAGFDEHPFKRSPATGKRIAVVGAGPAGLSCAHRLAMHGHDVVLFEARTKAGGLNEYGIARYKLVDDFARREVEFLLQIGGIELRHGQRLGDNLALGALHDEYDAVFLGIGLAASKRLGLEDEDAPGLLAATDYIRELRQSDDLLDLPVADRCIVIGAGNTAIDMAVQMSRLGARDVNLVYRRGFEEMGATGHEQEIAKASQVRLLTWARPERVLLDEHGRVRGMRFARTRLENGRLGDTGEHFELAADAIFKAIGQAFEGASLGDPLAAQLRRDGERIQVDGQMRTSIPGIYAGGDCVALGEDLTVQAVQHGKLAAEAIHAQLMLNVEAA
The following text describes a protein:
Function:
May be a carrier protein for lipids.
Subcellular Localization:
Secreted.
Sequence:
MKIVLICVLIGLVVAKQQKQDTLDEEKEKMKKWTQECIQESGVTSEILQQLRNQKRVEDPKLKEYTFCTFKKNGFMNEDGKLQYDVIKSTLMKVSGSEEEANKVVKDCVVEKSTPQDTAFETVDCWYRYKKN
The following text describes a protein:
Function:
Might be involved in the organization and polarity of the actin cytoskeleton.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVYFRQIFLMIIVVSLHCCKVRFFCIVANAKELDDWKVLTVENGERYRTHVGRYAGEEGGEKIKLRVLEKFRALLDLIKPSTSRRRNLAESASFSPWPAPSPSPFPNGGPIESPAYPPAPPRPIPPHLRRPLPQRTHPLEQPEIQRRKHEKGGTFKKILVPVVASTASAIGFVVCVVGVFCLCARRKRKMNGKTLSFKRKKGKSQSSTRKVSVNPTLDFLYLNSLGVDLERQNSVSVKEIRETEKDLNGINGGLLEEEVKRSIETEISHDWDNASSYSTKEIVSVHENDEEQTVNSVSVPVVVINDSSDDDESFHSVGGGSQYSNPRLSNASSASGSVNVGSSQRFSEHKLDIPECSRSDFGISVSAPPPPPPPPPPLPQFSNKRIHTLSSPETANLQTLSSQLCEKLCASSSKTSFPINVPNSQPRPPPPPPPPQQLQVAGINKTPPPPLSLDFSERRPLGKDGAPLPKLKPLHWDKVRATPDRTMVWDKLRTSSFELDEEMIESLFGYTMQSSTKNEEGKSKTPSPGKHLLEPKRLQNFTILLKALNATADQICSALGKGEGLCLQQLEALVKMVPTKEEELKLRSYKGAVDELGSAEKFLRALVGVPFAFQRAEAMLYRETFEDEVVHLRNSFSMLEEACKELKSSRLFLKLLEAVLKTGNRMNVGTIRGGAKAFKLDALLKLSDVKGTDGKTTLLHFVVQEISRSEGIRVSDSIMGRIMNQRSNKNRTPEEKEEDYRRMGLDLVSGLNTELRNVKKTATIDLEGLVTSVSNLRDGLGQLSCLASEKLKGDEENRAFVSSMSSFLRYGEKSLEELREDEKRIMERVGEIAEYFHGDVRGDEKNPLRIFVIVRDFLGMLDHVCRELRCVRVPNSPSPLAPFR
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MSSRPSSAVPNSASLSEDQSSDRSKFPKADDLIDERDRKLTELYCVSRLNQLLELTDENKLRKEIDAFLKKNDIRRGIRFDEASLPKLLHTAATPITKKKLKDVNLINVPNQRLSDSKMSRELPENSENVSVKSESHFVPSHDNSIRENMMDSLRPAEKTGGMWNKRPLESTMGGEEERHEKRQKMQSQSLESSNNSEMASLPISPRPPVPNALAHYTYYENIEYPPADPTEVQPAVKFKDPLIKNIMAKEIDTSDHYNENNVDALETVFLLMNDYIPSKIPQALPLAELKYMSQTLPLINLIPRAHKALTTNIINNALNEARITVVGSRIEELRRLGLWSLRQPKRFIDPWKQHNTHQNILLEEAKWMQADFKEGHKYKVAICTAMAQAIKDYWTYGEICCVKRKTLLPGKENKLSDDGRISEKSGRPSDTSRNDSDISIAGKDDIGIIANVDDITEKESAAANDNDENGKNEAGAKSDFDFADGLLSQEGAHDQIISSIDTKLLLKKPSSSSEVVLIQHEVAASSALIETEESKKELAPPFKLSIFVDELNTFEKTLIQDLPLYNGINEERPKKDDSLPFIPISKSVVSLDDNGFYKLLERQLIDEEPSISQLSKRRGMFYGNRRNHYLRPPAVPSLRYLQNRTPTIWLSEDDQELVKNINTYGYNWELISAHMTHRLTYSYLSNIERRTPWQCFERFVQLNERFNFSDLKGPRAHSAQQWLIEAHKFQQRQNRRISPLGVNTESIQRGHRRLRWASMFEAIRKCMKKRENTPRPNPTQPRKPLDCKNMKVPTPAEMSLLKAQRDEALRRDIQLRRTVKNRLQQRQQQSQQAHSSRAQSPIPSNGKSSSNLARNGQASAPRPNQKQYTEQDIIESYSRKLLEQKPDIGPEMALKAAKNYYRTLREQQQQLKQHQIQQQRQQLQEESSHVQQLQQLQPGSQAPPPKSSPSQSSLSNISNINSAPRIKSPTPQEILQRFQKQ
The following text describes a protein:
Function:
Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Sequence:
MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIEKEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKVQALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLCTAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSLAIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLRRLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGIVLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLSIILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISLHLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSGIGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTVFTVTLKRAAEKSA
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MPTTPQDLALAHSLAQRPPTDSSEAKEQEAGESDNLPNLCTLSLDELKQLDRDPEFFEDFIEEMSVVQYLNEELDSMMDQVEIISRENECKGIHLVELKRRLSDDFTALKNLGEKCDRLNKKYFKKSDEYAPQHIRELLQIAASNADGDCDRHVEHFLNGKTDVQTFLNTYQWSKKISTERKAKEERLGTQLSALERAGI
The following text describes a protein:
Function:
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Sequence:
MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRAVTITDLR