lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Secretory protein that acts as a feedback regulator of dpp/BMP, wg and hh signaling pathways. In the developing wing, is a dosage-dependent modulator of dpp/BMP signaling involved in wing growth and crossvein patterning; low levels promote and high levels inhibit dpp/BMP signaling. In the early pupal wing, inhibits dpp/BMP signaling activity to prevent the formation of ectopic crossveins in the posterior compartment. Binds to dpp and gbb to modulate their release and activity decreasing dpp/BMP signaling in the responding cells. During wing development regulates dpp/BMP coreceptor dally availability on the cell surface. Might have a role in testis development.
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix.
Sequence:
MQRSTMLPGVELLLLFLLSTSLHAEISHLPMASNRIILDSTELLQNPLIQDAGVPAARATPLPPQKCPSLQRYRKMLKDFDDLEDLYVDVPVHIALAERQRKRFVLNLNDSTPLTIRFSAPVGRKMYYNQTGNPLRPAAVAPGPGVAVGSLVLPCALRGQYDLFVLARHSGALKVDALAEHPQHDWPLLNATHRIAIRTQNRVRKREMIVKWERSKFDFHVMHYCLVIQRLSMDTPRMIFTNFCQAVSAYTDQQPMTPSCAAGGPLEGIWGAPPQRERRLNPRQNVHIVCTGKRRQQLLRRLLPRSSYHLDLFGIHQGRQNLTLRLASSQVNFNRTQPLALKQQALMQLKIGGQHGKQVYSFKVPQTTRQLGEPFMRHLLIPCSGSEIRVKLLRQRSEVGKTEAFYSPTYIRQKGVLPGERYLMRFEPSNDDEALRAQKVMVALSSEALFRDLPELPQNTTVFNVRTRCSRATIAWNGSPDERELSYCIIVFNLPQRNRSVVDFTNYCMDFVPKRVMQYRYFEWMTCRERQQSPDNIETETILNLMPGSSYLVYVTANLSMGKPLPYQALTLHMASQCLDGSHESFY
The following text describes a protein:
Function:
May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKTRLKFQVDKDLLLAIVVGVCGSLVALAMFFLSGYMVTQSALGAPLYALMILVVTVKLFGFLRAITRYVERLISHKATFTMLRDIRVQFFGKLVNVIPNVYRKLSSSDLISRMISRVEALQNIYLRVYYPPVVIGLTALVTVIVLAFISIGHALLIMVSMLFTLLIVPWLSSKKARTLKKHAANEQARFLNHFYDYKAGMDELRRFNQINHYRDNLMAKLNHFDKLQLKEQRFLTIYDFILNIIAMLSIFGSLVLGLIQINAGQLNIIYMTSIVLMVLTLFEQAVPMTNVAYYKADTDQALHDINEVISVPSTNGKKRLNDKYDATNIYEVKDASFKYWNQQTYVLSDINFNVNRGEKIAIVGPSGSGKSTLLQIMAGLYQLDSGSVRFENMDMFEIDDKDKFESLNVLLQSQQLFDGTIRQNLFTDEKDEAVQAIFKQLDLEHLALERQIDLDGHTLSGGEIQRLAITRMLLKDTASTWILDEPTTALDKQNSLKVMDLIEAHAETLIVATHDLTLLSRFETIIVMINGKIVEKGNYQQLLANQGALWNMIQYNA
The following text describes a protein:
Function:
Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
Sequence:
METMKYNEDYQMNNHTIHTIPTKAGSLKVGGFVVIGTFPCKITEFNKTKDGKHGHAKVTLTGIDVFTGKKYTDCCPAHSNVDVPVIKRVEYSLQDIDDGYLTLLDEDGTVRSDIKLPKNELGKEIEHDFNEKSLICIIQVFGDQEMVVGYKEDKD
The following text describes a protein:
Function:
Beta subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) involved in glucose-induced cAMP signaling. The beta-gamma subunits (git5-git11) promote binding of the alpha subunit gpa2 to GPCR git3, which senses extracellular glucose, to activate cAMP-PKA signaling and repress sexual development and gluconeogenesis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus.
Sequence:
MDSGSRVNVNIQGTRVLKNKLGKIPDIDISTDGKYLLSASTNDVLLVWDLHTSNKVAFFEAPSVWIMTCAFSPSTKSIAAGGLNNFCVVYDTSVPDADPVELVGHAGFVSCCKYVDDGHLLTGSGDKTCMFWDIEQAKAISVLKGHEMDIVSLDFLPSNPNLFVTGGCDKLAKLWDLRAAYCCATFPGNTSDINSISFFPSNADFVTGAEDGIARCFDIRASAEIFQYSSPSSSPINSVLFSKSGKLLFIAKDKTCEVWDSISSKTITSLTGHENRISSLALTSDGTMLATGSWDECVRLWSSSG
The following text describes a protein:
Function:
Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
Sequence:
MKGELIENRVIVWNIEDSRKLFGGGYYGKPIGIPKPKIEEIDAPLVLDLIESLYLLENKKISISKSKHKVTVEQMIDICKNEHHDFDKKYLVYKNFRDKGYIINPGIKFGCDFAVYEKGPGIDHAPFLIQVYNRSEPITSTGIVLAGRLATSVKKQFILAIPKGKDNVDFLALDWWKA
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAGEKSQPADHHQPLEEPQEEQEAPVDDVPDDSAQASAPAAARAPHDVPRQHEYCSMSTVLADYAPAGEPLPPTSSDEALAHQLHMEELMDQDPENRGWRQQVNGGWGGATLTADSAGLSLTARNPGPTPMSRIMNTRELRAAEHRLWSTAAIGLPSATTPPPAAATASAGWNPSAATAAALGIAIAPPAADADFVYKKRRDLLADANSPTIFAGMEEEEDNGFYESIIPNPDDDEKPEEVEKEGLHESLQQCLAPRSDRANNEKEKPYNNNSTSPVAVAAAGEEEEFCLDKFCEKWGISPSHPDLHPDDRDEAGPSTKKRTKVPPLADDEILKFDCGICMETLPVFDLFHGLPCEHKFCAPCMSTYVEARIRAGELPIPCPDPSCKGDDGSKVVLHPEKCKKAIDYAAFSDWGARVTESALLPSRRAYCPNPRCGVMLETAACGGQDQEPTKAPCPACKHLLCATCGQEWSADGPEGVHDCAHGPEAVAVKKLAAEQLWQICPKCKMYVEKIAGCNTMKCRCGLFFCYRCGHPMTRQAEGDFGEPCRCSYDTADLGFAFPVAHQHQQQPPWFDFDMDPLAPQPGAWNDILEDRQGEGWNQDEEAMD
The following text describes a protein:
Function:
Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nuclear localization depends on ctr-9, pafo-1 and cdc-73. Located in nuclei before mitosis. Located in the cytoplasm upon mitotic nuclear membrane breakdown. Located in nuclei when nuclear envelope is reassembled in telophase.
Sequence:
MSSSEGNSDASAPGTPVKSSTPSSRGSSPDSPKKQEPSKKRAILNESDDDDDSRPAPRQLSDSSDDNIHPRGGGEKSSPGAGGGLFGDLSGSSDDDSDREGKPKESNTRARLSDSDAESRGSLNDLQGIVMANPDEIDEDEKAKEHVHDTEMVTGRVTLEYAADPPHFVRMPNFLSVATHPFDPQHYEEDEDDEQAKLDDEGRTRLKLRVENTLRWRVRKDENGKEIRESNAKIVKWDDGTMSLYLGNEIFEVSLVPLNSNNLPHLYVKQPTLMSAQAVLTHRMTFRPHSTDSQTHRKVTLNMADRSRKNAQVKVMDDVGQNPEITRRENARKEEESLRAHIRRTQMVRNNFKVRGPRYAGQYSDDEDMPTSSRKGKKKEAPIIGASSESEDDHADTTKKSGSDSDSDEEYRKRKQQQKKQIVTSDEESD
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MNYEVKKLEKSAVEVKLHLTAEEVKPIVDKVLAHVGEHAEVAGFRKGHAPKEVLMTNYKDHIESDVANDAINANFPEIVDKEKLEPVSYVRLKEINLKDDLNLTFDIDVYPQFELGNYKGLEAEKKSFEMTDDLLKEELEIMVRNHAKLEEVEDAGYKAQLDDTVDLAFEGFMDGAPFPGGKAESHLLKLGSKSFIDNFEEQLVGYTKGQEGEITVKFPAEYHAAELAGKPAQFKVKINAIKKLRQPELNDDFAKELGYASLDELKAKTKEETTKRENDRIENEYVSALLDKLMETTTIDVPVSMVQAEIQNRLKELEYQLSMQGFKMDDYLKMMGGNVETFAAQLAPAAEKKVKIDLILDRIAKDNNFEATDEELNQRMEEIAKMYGMDVPALEEELKKNKNLENFKASVKYDIVMKKAIDEVVKNAK
The following text describes a protein:
Function:
Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity).
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes; MISCELLANEOUS: Present with 2910 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLRTRLTNCSLWRPYYTSSLSRVPRAPPDKVLGLSEHFKKVKNVNKIDLTVGIYKDGWGKVTTFPSVAKAQKLIESHLELNKNLSYLPITGSKEFQENVMKFLFKESCPQFGPFYLAHDRISFVQTLSGTGALAVAAKFLALFISRDIWIPDPSWANHKNIFQNNGFENIYRYSYYKDGQIDIDGWIEQLKTFAYNNQQENNKNPPCIILHACCHNPTGLDPTKEQWEKIIDTIYELKMVPIVDMAYQGLESGNLLKDAYLLRLCLNVNKYPNWSNGIFLCQSFAKNMGLYGERVGSLSVITPATANNGKFNPLQQKNSLQQNIDSQLKKIVRGMYSSPPGYGSRVVNVVLSDFKLKQQWFKDVDFMVQRLHHVRQEMFDRLGWPDLVNFAQQHGMFYYTRFSPKQVEILRNNYFVYLTGDGRLSLSGVNDSNVDYLCESLEAVSKMDKLA
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MAMFVPRRSLPPLNAVRAFEAAARLGSFKEAAGELGVTHGAVSQQIRLLETWLGPPALFRRSVRRVVLTPAGAALLAEFAPALDRVSAAVQQHRKRRGEAPAAVLRVNALATFSLRWLLPRMTRFRAEHPDIEVRLSTSNDPVDALPELFDVVIRGGPDTFHGFASRFLLSEQRLPVCSPALLAKLPLTEVADLSRHTLLHVTSMPRLWRDWLTDAGESALEGAASLTFDHFYLTLQAALDGLGVAMGPTALIADDLAAGRLVTPFPNISLPARSYFAYFPEGRDDDPHRAVFCDWLEQQGRQTV
The following text describes a protein:
Function:
Essential protein involved in plastid gene expression and in chloroplast biogenesis. Links photomorphogenesis and chloroplast biogenesis through its dual localization; required for the formation of late photobodies in the nucleus, as well as for phytochrome B-mediated signaling cascade and subsequent reshaping of the plastid-encoded RNA polymerase (PEP) activity. Binds RNA via specific recognition motifs of viral origin. Recruited by MTERF5 to the transcriptionally paused region of psbEFLJ. Promotes leaf greening.
Subcellular Localization:
Plastid, chloroplast. Plastid, chloroplast thylakoid. Nucleus. Nucleus, nucleoplasm. Note=Translocates to the chloroplast via its transit peptide and then take part of the plastid-encoded RNA polymerase (PEP) complex. When in the nucleus, can bind to PTAC12/HMR/PAP5. Both localization are observed in the dark or under white light, mainly present in the nucleus of etiolated seedlings while enriched in chloroplast after light exposure.
Sequence:
MASSAASPSLSLLSFTSKPPYPSGSQRLFASFRTDGLFAPLTLKSRRGRGIVVKVDDVDADGGGADEYDMDDEEVEEVDNKKDYDVEYDPLAAAIAAAGGGGDGDIAFVQSKSFISTQGWDSDMVVDYRINEDEFHKLSLMDCDFFIRKPPDPDNDVYDFREMYVTPPDTDIYSIPRVLAPMPQKYIRCAMSDYGCYNVTEPPIDAPRDPLYKSEREISKVFLTKHYRNRRTNDPEFVLDLEEIYVIDSKTKSITRARVLVTVPGGRKRDRKDDLLVIRDNGTSFKIIHVGERDDPTTVIEREEWTKTREDMEKHLRKLRDFSVSNWF
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRSSATKGAKLKNSPRERLSSFNPQYAERYKELYRTLFWLLLISVLANTAPITILPGCPNRFYRLVHLSWMILWYGLFVLGSYWEFVLVTTQRVSLDRYLNAIESAIYVVHIFSIMLLTWQCRNWAPKLMTNIVTSDLNRAYTIDCNRTKRFIRLQLFLVGIFACLAIFFNIWTHKFVVYRSILSINSYVMPNIISSISFAQYYLLLQGIAWRQRRLTEGLERELTHLHSPRISEVQKIRMHHANLIDFTKAVNRTFQYSILLLFVGCFLNFNLVLFLVYQGIENPSMADFTKWVCMLLWLAMHVGKVCSILHFNQSIQNEHSTCLTLLSRVSYARKDIQDTITHFIIQMRTNVRQHVVCGVINLDLKFLTTLLVASADFFIFLLQYDVTYEALSKSVQGNVTRYK
The following text describes a protein:
Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.
Sequence:
MAWTSVLLMLLAHLTGCGPQPMVHQPPSASSSLGATIRLSCTLSNDHNIGIYSIYWYQQRPGHPPRFLLRYFSHSDKHQGPDIPPRFSGSKDTARNLGYLSISELQPEDEAVYYCAVGLRSHEKKRMEREWEGEKSYTDLGS
The following text describes a protein:
Function:
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1; TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Subcellular Localization:
Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
Domain:
The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1; The C-terminal domain forms a four-stranded coiled coil.
Sequence:
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEGKKKEHKKVKSTRDIVPFSELGTTPSGGGFFQGISFPEISTRPPLGSTELQAAKKVHTSKGDLPREPLVATNLPGRGQLQKLASERNLFISCKSSHDRCLEKSSSSSSQPEHSAMLVSTAASPSLIKETTTGYYKDIVENICGREKSGIQPLCPERSHISDQSPLSSKRKALEESESSQLISPPLAQAIRDYVNSLLVQGGVGSLPGTSNSMPPLDVENIQKRIDQSKFQETEFLSPPRKVPRLSEKSVEERDSGSFVAFQNIPGSELMSSFAKTVVSHSLTTLGLEVAKQSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSREATQILSVPKVDDEILGFISEATPLGGIQAASTESCNQQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQAAQILSSDPSRTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNKH
The following text describes a protein:
Function:
Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, Z line.
Sequence:
MMQGNKKCTDGFSDTSSIGSVLDEADREVSNLTDRAFRSLCISEDTSFHDSDLALSPDVTSQVSGTFHQETVGHANRKSGIWSQLPSQGTEHSGWAATFQQQPKYVQGEEKYPKTSPLPTPVQRRLEVPISGLRSSSKPISKVSSLIRSFDRTETQSCDSRPPPSKPPALKNPPKFAHPPESGVNFCFDSAFLTVRRVPAEVSNTHQGSHQSGRAPGEQESPKNPEIASHSSDSLLRTPDHVAGSFEPRYPSPPLKPATAEPGRGKEWIPRRTFLHSENSAFESWDTHQPKLRERKDIAETTPESKAPKHYEDMPLLKEPYPAESKGSPYQARANCAQEENRSPSGSQSTSGAWGARDPGSQLFPVEGNASQIDPQVKRSKAPWRKPKTGKGGTDGPPDALEDKKQPNRRGLPLYSKLNPQGQLPENGVLDMPEESNDHYNPPFNISKLLTPIISTKHVLETSDTQPVEISPSPPGQLNGYQEKESSEAQSRDSYKSKAPSLLFNLKDVRKRVKSTYSPLPLLKGFDEKTRGKLDSKQEPLSNGVTLPDGLEENPPTELLPDNVPGVLHSSTQKDPAINSRESFAVSHPTFSSPSASSQTHFCVNGEAAESNSNEKEEANGESELDPSKGGGHPDCRENLPRKHLSLKLFNRESEMGPAMAEMKPHQLENGLSRSVSQETETERETGFQSLPLNQKFSPGPLSPEEEDVFYSDSQSDFTPCRQTKAKFSTSSSDQSFASFEDQQKVCFTEGPQEDRKSHVSAGDKQRDETAVEKEESQQCASRNEHRGVDEQRQEEIQRKAQGVSGGRPRKASAEDLSARGSWMGADKDTAHTHAKDPTPLPASTNKHRLFPIKDNTLRATPVIKPIILPLLRTVSSEDSLSSGHQENELPKQLWGEDAGGLSASESQEMPNTPLSNNDVPGTQHRCMVCEDVQEDPVHTAAQDETSQQTRKGSFSFLPPVEEENRMKPSPDTAGEGLAQEKSKSADLGKLGVPQRIPTIALLPDDLEDSPPSLPQHTYWEEQGFKGHFLSAPRAGPSGRRLVPSEAETSPNPSSLGESSTCSPAASSIWEEASQAAGEHWQRQEPPGPNPWASPGPTGLTRREDMTHGLTWEAEGSDPSDFRALSPRGILLADAAEKPEPPALLEKAAGKPPAVPPKTEKALRRAKKLASKRRKSDQLLEKHTEAWEGKSFTEDTQGTERRPVSPGKGPRPRFPAIRSLPPPTHRHSVSCGWEPTGRRPWGPQSLTPLPPYPATQKVLQDPQSGQYFVFDVPLQVKIKTFYDPETGKYVKVSVPSSEEASSEPPLQDALAAPYLLYPGFRPVPVTSVMPLRCSSQLAAPTFLRQGSGHRPQSSQGSRLQPPPERLGESTQHASGQCPRGPSHSPEKESAEAPRLSIISTDDLEDFATEGVS
The following text describes a protein:
Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Sequence:
MATAKSLQPRMFSSFHGNNSIRSTQPLLHLFRIDVGRRHVSMQLSRTFSGLTNLLFNRRNEDEVIDGNRKRLKPGNSLESQVDSRFTTRKLEFVNTLALWLSQVVCTSVNECICHGIPDSRPLEDGDTINIDVTVYLNGYHGDTSATFFCGDVDEKAKNLVQYVTKESLDKAISICGPGVEYKKVGKTIHDHADKHKYGVVRQFVGHGIGRVFHADPVVLYFRNNEAGRMVLNQTFTIEPMLTIGSIKPVMWDDNWTVVTEDASLSA
The following text describes a protein:
Function:
Specific, proton motive force-dependent high-affinity transporter for xanthine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSDINHAGSDLIFELEDRPPFHQALVGAITHLLAIFVPMVTPALIVGAALQLSAETTAYLVSMAMIASGIGTWLQVNRYGIVGSGLLSIQSVNFSFVTVMIALGSSMKSDGFHEELIMSSLLGVSFVGAFLVVGSSFILPYLRRVITPTVSGIVVLMIGLSLIKVGIIDFGGGFAAKSSGTFGNYEHLGVGLLVLIVVIGFNCCRSPLLRMGGIAIGLCVGYIASLCLGMVDFSSMRNLPLITIPHPFKYGFSFSFHQFLVVGTIYLLSVLEAVGDITATAMVSRRPIQGEEYQSRLKGGVLADGLVSVIASAVGSLPLTTFAQNNGVIQMTGVASRYVGRTIAVMLVILGLFPMIGGFFTTIPSAVLGGAMTLMFSMIAIAGIRIIITNGLKRRETLIVATSLGLGLGVSYDPEIFKILPASIYVLVENPICAGGLTAILLNIILPGGYRQENVLPGITSAEEMD
The following text describes a protein:
Function:
Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MMLSEETSAVRPQKQTRFNGAKLVWMLKGSPLTVTSAVIIVLMLLMMIFSPWLATHDPNAIDLTARLLPPSAAHWFGTDEVGRDLFSRVLVGSQQSILAGLVVVAIAGMIGSLLGCLSGVLGGRADAIIMRIMDIMLSIPSLVLTMALAAALGPSLFNAMLAIAIVRIPFYVRLARGQALVVRQYTYVQAAKTFGASRWHLINWHILRNSLPPLIVQASLDIGSAILMAATLGFIGLGAQQPSAEWGAMVANGRNYVLDQWWYCAFPGAAILLTAVGFNLFGDGIRDLLDPKAGGKQS
The following text describes a protein:
Function:
Enzyme with a broad specificity.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MGPYLSQPKTEKSTVTGQNQVFQYAATHMQGWRNTMEDAHISDMNIEPDVHLFAVFDGHGGSEVAIFAERHFREELMKNKNYQQKNYEKALTETFFKIDKMLQEPSGQDELNKIRGVNDETSLAGCTANVALIVGKTLYVANAGDSRSFLNRDGKPFDMSKDHKPDDDQEKKRIERAGGFVSDGRANGNLSLSRALGDLEYKKDSRFKPEEQIISALPDVKVTQLTASDKFLLMGCDGVFETWDHQQILNFVNQELKSSQNLQKATEKLLDQLLAKDTSLGTGCDNMTCILVLFK
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Subcellular Localization:
Nucleus.
Sequence:
MQILKDQENLNPDGGSFVLITPPLSPPKQKSLSYTNISRRHGMRACMKGIVYEVYKNQPKLWLQQELIWLRRKRIHPIPKARRNNHVGRWANRHSNVSSSSGSRGRSSVSSRDSSPSYSGALRSAERSISSSPSTIEARRRKSARGNGLNGAIDVANLPFEELPNFCPDMSVLDNRTHPRTLKAEWKGPPLDLSDDPYRDLLHPAELHLASTLRLPCLIYLDNKKRIFAEWHHRRQQGLTFRKTDAQRASRVDVNKASRLWKAFHEVGFFDD
The following text describes a protein:
Function:
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNIILFTSLVAFFVFLLILKYWINFQKSKGIGKYIRKEGPSSHFQKSGTPVMGGIIFLIVSIPFLFFKETFFPSLSTILFGLLGLLDDFKLMVNKDYGIRPLRKIFLSFIITLLLYIFSFHDYKIYWGSKLIISSRIFYVILFFVVFIAVPNAINLTDGLDGLAGGTSLITLFFFLIYNFQFNNELTLEISLMITALIAFLWFNSHPAEIFMGDVGAFALGGFIASLSIINKVELLLVFLGGIFLIESLSVFIQVFFYKWKKRRVFLMSPLHHHFELKGWKETKVVWRFYIIHLIMMIGGIILWNLT
The following text describes a protein:
Function:
Binds microtubules.
Miscellaneous:
MISCELLANEOUS: Present with 3630 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSAGIGESRTELLTWLNGLLNLNYKKIEECGTGAAYCQIMDSIYGDLPMNRVKFNATAEYEFQTNYKILQSCFSRHGIEKTVYVDKLIRCKFQDNLEFLQWLKKHWIRHKDESVYDPDARRKYRPIITNNSATKPRTVSNPTTAKRSSSTGTGSAMSGGLATRHSSLGINGSRKTSVTQGQLVAIQAELTKSQETIGSLNEEIEQYKGTVSTLEIEREFYFNKLRDIEILVHTTQDLINEGVYKFNDETITGHGNGNGGALLRFVKKVESILYATAEGFEMNDGEDELNDKNLGEHGTVPNQGGYANSNGEVNGNEGSNHDVIMQNDEGEVGVSNNLIIDEETF
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MCSIGDDGLEEVPSKPPRDATQRMCMKCSSSLAVVVVRLNDPLCKDCFLAYCTHKFRSTIGKARVIRHNERVLLAVSGGPASLAMLHFISEATSARRLRFHPDVVFINNGAIIGVSTQDIVRKIHEVTMKAGFALHVVGLETLFRADKMSPEESLQALQTLFDSVTSLTAKEDLLRSLHQQLLVKVAMDEGYSRVMVGDSANNIAVHILSDISQGRGGALPFITAFNDSRHDGISILRPMREFIAKEICLYNHFMGIDAISTNSLATKAGINASINKLTEEFISGLQAQFPFTVSTVFRTGDKLSLSEEKCDIHCAICKVPVSSADRNLCKRLEHLAINHSHRSDSSPPSNNIGSACSSDDTGGSPHQSTSLKDMLCYGCQLTLKDVKQDITGLPFVQDCIQRISNREVINSSIQEFLLPDDKS
The following text describes a protein:
Function:
Possesses DNA- and RNA-binding activities. Binds to DNA with relaxed sequence specificity. Associates with the subtelomeric TARE6 repeats.
Subcellular Localization:
Nucleus. Chromosome, telomere. Cytoplasm. Note=Localizes to the nucleus in the ring stages and expands to punctate loci in the cytoplasm during the trophozoite and schizont stages.
Sequence:
MPGSTKSDTKLENEIRISYKSDALDYVYKAIVLFETYDEIILSGVGKAISSVVNVAEMVKRRAKGLHQFTKLYEKEHVIKREDNSGLKKNAKNEDKKSGDEEEEEEEEEEDEENNKNKEANNRTVEFITTVPCMKIILSKNEDKIDKNEIGYQKPLDEKEVNVMTPEQILKEKSYRRRYRRGGRGGDRFRSYRRNYYETSMWNNRRYEKRN
The following text describes a protein:
Function:
Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.
Miscellaneous:
MISCELLANEOUS: This protein strongly binds to glucan and chitin; MISCELLANEOUS: Present with 45000 molecules/cell in log phase SD medium.
Subcellular Localization:
Secreted, cell wall. Note=Tightly bound to cell wall.
Sequence:
MRFSTTLATAATALFFTASQVSAIGELAFNLGVKNNDGTCKSTSDYETELQALKSYTSTVKVYAASDCNTLQNLGPAAEAEGFTIFVGVWPTDDSHYAAEKAALQTYLPKIKESTVAGFLVGSEALYRNDLTASQLSDKINDVRSVVADISDSDGKSYSGKQVGTVDSWNVLVAGYNSAVIEASDFVMANAFSYWQGQTMQNASYSFFDDIMQALQVIQSTKGSTDITFWVGETGWPTDGTNFESSYPSVDNAKQFWKEGICSMRAWGVNVIVFEAFDEDWKPNTSGTSDVEKHWGVFTSSDNLKYSLDCDFS
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MALNSPTRCAAPLTRSVPPRSPLALFNRTLPRPAFSTESPTARLVSVRCQTLTPDGVPSKRPVGLDESEASIGSSGSSSTSSAIDFLTLCHSLKTTKRKGWINHGIKGPESIADHMYRMALMSLIAGDVPGLNRERCIKIAIVHDIAEAIVGDITPADGIPKAEKSRREQAALNEMCIVLGGGMRAEEIKELWAEYENNSSLEANLVKDFDKVEMILQALEYEIGKVFHSFAVTLLAFLSFSSDIFTLVTEHGKVLDEFFISTAGKFQTELGKSWAAEIISRRNSRVDKSHN
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893. MpaDE is an endoplasmic reticulum-bound enzyme that catalyzes the conversion of 5-methylorsellinic acid (5MOA) into the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP). MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB), and then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP. The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC. 5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE. MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB). MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP. The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP). The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate. The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C. After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight. Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps. The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process. Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (Probable).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MKSLSLTWITAVAVVLYLVQRYVRSYWRLKDIPGPVLAKLTDLQRVWWVKTGRAHEFHRDMHAMYGPIVRFGPNMVSVSDPRVIPTIYPSRPGFPKGDFYRTQKPYTRNKGAMPAVFNTQDEDLHKQLRSPIASLYSMTNVVRLEPLVDETLTVLSKQLDERFVGTNDKPFDLGDWLQYFAFDSMGTLTFSRRYGFLEQGRDMHGILQEIWNFMTRVAVMGQIPWFDEIWNKNSFITLFKRPTGFGVLKVVDNFISQRVSSRENDEKADEKDMLSQFLDIQASNPHSIMPWAPRAWTFSNVMAGSDSTANVMRTMMYNLLVDRDTLRSLRAELLEAENSNGLSRSLPSWDGVRSLPYLDACVLEALRLHPPFCLPFERVVPEGGITVCETYLPAGTVVGISPYLANRDKQTFGDDADKWRPSRWLDLSREDRVKLENSILTFGAGRRTCLGKNIAILEIKKLFPMLLLNYEIEIVNPENYQTTNAWFFRQWGLQAVIRKLPAPERDDTIEQKASIPPALNIPPSSSTVEVRIIDSGTLLDLRPDLFWTPDLPGLLKVTAPTYCFLISNGTRHVLFDLAVRQDWENLPPSIVAMIKSQTVIQEPRNISDVLDSDESSLGVRSKDIEAIIWSHAHFDHIGDPSTFPPSTELVVGPGIRDTHWPGFPTNPDAINLNTDIQGRNVREISFEKTQKGATKIGSFDAVDYFGDGSFYLLDAAGHSVGHIGALARVTTSPVSFVFMGGDSCHHAGVLRPTKYLPCPLDSGDTSLPCKSDSVFTLSPALPTDYTAALRTVENIKELDACEDVFVVLAHDATLKGKVDFYPSKINDWKAKEYGKKTKWLFYKDIENSIEGQK