The following text describes a protein:
Function:
Essential scaffold subunit of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs) (By similarity). Required for SAGA recruitment in a gene-specific manner.
Miscellaneous:
MISCELLANEOUS: Although strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, suggesting that it may lack such activity.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal domain (2233-2836) is essential for its ability to interact with activators; The FATC domain and precise positioning of the C-terminal carboxyl group are required for stability and function of the protein.
Sequence:
MDVSQCEHWHNRLCDVGLDSKQKANTAIEIRDALDDVLVTEKTNFETFIPLLEDTLSLLEKERPVFSSLAATHRLRIALLELLKKSGSYKGFEAFVNRTFAVLLRIVVNDNEEMAVLALKLVVLLFKDHSSLAKGHVQEFLSIVVENYKSMTTVVSEAFPPRSAPNTPSSHPMSAASSASPAEIGMEHAGPKMIPKASSSFKVTAEFPIIVFLLFQTYKDLIPKMLPLLAPLVLQFISLRPPPQAEARRLAESQKEVFIGVVPSLRRNHLYNDLISAQIKSFSFLAYLLRSFGAALKQFESSIPICTLQLFMDCPSELYQTRRELLVATRHVLSTDYLRGFLPYVDQLLDTKILVGSGITSQHSLRPMAFSMLADMLHYVRMELSPQQIYKVILLYFSILMDDFYTSAIQAMATKLILNLVERIVALEDFSTSRSLLFAILLCLLRKLTSLNFEFMKLRDSLQENADLKQIKIEENKHDLPMFENPTGAAQPSGLDKLKDCIFLFKNTLLGIKPVLFGLKQRNIPLANGSIFTAQEWSEKLHLSSTNEVLLFRRLLVESLKGFSYYQTDEKTGVFKSSKNLAYSQLDSSLTTNPSKLLEEKELLEMLATLFLHLDPSVFVEILESEFPNIFECLVDNLALLHIFQFWMSNEVTSVNCTGIVLSFCCDNLAKIGSGQSTRVSVLLRLFKLAFMTVNVFPEKNAEVLRPHISYIISTSLELTTDAVEPLNYVYLMKALFRNISGGKFDSLYKEILPLLQVMLECFNRLIFTVTSTSQKELYAELCLTLPIRLSVLLPHMNFLMKPLIVALKGPPEIASQGLRIFELCLDNLTQEFLDPLLDSIMPDLLICLWNHSRLNQSNNQLHQSAVRILGKMGGRNRQIYLGTFGFDFLQDENIFPSIQFSFQGSSQNFSLEHSKFLMSSCAVLNNQNSDLEEKKQAFQMVKNSYLLLFASAKPDEDFWESIDTMCRAVVDRMDKNLQQVSNGRLCPDKDESYYLQRSIVSNIFKSLVGSMSCVEFVAEARETINRSLEWLIVLDLVNYADSLQIKDQNIFDNLQSIKMLDLTTCINGIFESLCSENENTRSNALSCIDHYLNAHKMLLNTTLDISKLPSFQNLVTVFCQSCHKELWYQKNAGFLGLKAILSYDSHHKLWIQDRLHDILKALFFILKDTPTDYGVLKLTEVRSFIVDITTQFCILQDVLAPKERANNIINAFSPFFLELLHPNDHVRNTVQQAIENISNNSKLSVVDLLLPIKDRLLSPIFGKPLRALPFTIQIGHIDAITYCLHRSPSFLDLTDELYRLFRETIALADAEDEALVTMLKTSQSKDSSSLRKLRATCLHLLFASLVAHKFDQPQHAQTRTKIIAIFFKDLYSPHKEIYSVAIDALRHVLSQNQKLPKELLQSGLRPILMNLSDHNKLSVNGLEGLSRLLRLLTNYFKVEIGRKLLQHLNVLSDSKVLETASLSLLKTNPRIEIIVSLVNVFRDLPPLSAQFLGDLLSSVVNIEAVLRKYSNSPLRKPLYSFMDLHANDTWMYILNNARNGDLITRFVGALNDPMSEKLRETAGNYWGKLLELISQPVSVENLAPMYAVDIIATVFPYISANVDAGVISAKFIVLSKSLYGMLSSYNEYLFLPIRRCISSITKMLLSSLKKIEKKLEFSLEVFRFKADDDNDFLPEYIDSLCGCLITSTSAAEKKSIFLVCCSIVGDKSVRPFFKAFLLDKVINPLVFKSCGENNFIDKDVVHSVYTHVWRVSIRDFAEVSGATDSFYMGIMCLTTALCKYHSALLNDYRKSVIMSAWNYIKLEDPMVKQAAYATIACFISAYDTPAKIVTPVYVSILKTYQPEVRAFIEFSLASLLSVLTARLSSPSDSTFPLWAKLPRLVISEDVQGISQPLTVYQFICKAPDLFFSCCSHFIVPMVNALPKLVSFSSASTEPRKLALDIVQTFINWQRKQNESENSETTLFSNSHIEAILTFLIKFLSLFPEPVEENPLSKKGLSLFNDLFSFPRWKDCQLNSNFFEKILVDMDFNDNNYRTVANTLFVFGVILKNRGMEYIQREYSHIIALIDKSLRCGKLPVTHSLEQIILLLLQSHPTQAEEEEDTNEADDFKQLLLSVIHDNLAAATNIESAICYLQIVKSSNPEALDGLLLPLNKCFQKVARDHIVACMQSAIQASGKVTLPSASDTVSKLLISFIEIIRVRMASLGDQRRWFLSVVVQLLEKSSSFELCEHILNVTKEWVIVKRDSFLTVKEKTALLLKMRTFEGRFDNKLYIEACDLLSTIYRDPIFAHTELTARLKQAFLLATASKDTKIRMDFMDIFDSSMSRNVYSRLTFILDATSWDTIPSIYWIKQANYILLGAINAKQPVRLTDNSLRFAPVPMTKPILSSLPEVFSKHNGSAIPLGRFTFFKQLDLFLKRNKELTVQKIIFPLAHIQMLSDADANKLWQYIFPLAWKILSSDNRSDLSKSLIYLLTRDYHIKQVNNRPNVISTLVSSFVKCAAKLELPPHLVKYLGKLYGVYHESVSLLEIQLSDKYDMYQNAKVQESRADAVAELYASLNEDDMFYGHWRRNCKYLQTQVALSYEQLGMWGRAQQLYEQAQTKARSEAIPFSESEYNLWEDQWVMCAQKLQQWDVLTELAKHEGSSELLLECAWRISDWSNNRESLEVAIKSLSDVPTPRKLTFQCFMTLQKSVSQPLAIKEFQQVLSEAIQLALIKWHQLPEKVNQSHYSLLHLFQQFVELQEAATIYSHLNAINFQNLPTNVQLIKSALQVWQERLPNVWDDINLWRDLISWRQIVFSMINRVYLPLVPTIQANSSADSSNPPNTSFLFRGYHETAWLINRFAHVARKHKLPSVCLNQLTKIYTLPNIEIQEAFYKLREQVLCYLQNPRDLKTGLEVVTNTNLMYFNSRQKSEFVTLKGKFLEKLNRGEEANQMYAAAVQIDLGLPKAWAEWGRYNDLLFNKSPDNLSAACNAISCYLQAAGTYQSSKARKMLARVLWLLSLNDSAGTIVKAFESYKGDIPVWHWLTFIPQLLNSLSKGDTKCAPVVLKKIAKSYPQALFFTLRTAREDIAQVKRTEMAAWKSNTTDENKRNEDILSIQSNFLSTNQSTNAPATNKEDGLSKKVWEYIDEIMSILKTAYPLLALTMETLVDQIQAKFKCKNDGDAFRLVVALLNDAVQHSIRLGIVTDEMKLPSSTESNLSLFADNILPDYCKQLFKEDFIVNSNGLKSYIFKLRKWRSYFERLLSKVPKKQYLEQYSSFLCEFHHQKFDEIEVPGQYLLHKDNNNSFSCIERFLPEVELIVGHGVCYRRLSIRSNGGTIHPFVIQYPSARNSRREERFMQLTRYLNDALALNCETRRRCLKFYIPAVIPLSSHIRLLEDQPSSITLQKIYEIYSERNNFSRDDPKELFTNELSKHMMELNSQISQESTDAEKLANRKQLFSRRIGMFENIQKLYSPSTILKDYFSSIFTNYSDLWLFRKNFSYQYACFSFITYILSINNRIPAKLVFSRDSGGVWTTEALPSMVSSTPVYHNGEIVPFRFTPNIKEFIGKTCTEGLLGPSIMAIARALSKPDFDLDMYLGIFIRDDLFWWLAQQTKGVPADFSMLNKVNSNTDLIMRRVASLSQVAYGNLPVNQTAIDYLAQASSSKVLAQMDVLWAPWL