lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MGLPPELAENRGGSGSTGSISARHGITRIFQRLSRWSPVIQSAVSGSWRRTSGVAAVAFNKERDPGQKLLGDKIGEDRTKPGIEPTTSWFLVGFLSAVPQRELLDRELFKLQQMYGEVDKTTFPNFMFEDPKFEAIEKPDIIIIIIGIGILLLS
The following text describes a protein:
Function:
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Subcellular Localization:
Cytoplasm.
Sequence:
MLFKDLKEFEFILSEERIARYPVANRDESRLMVLDVNTGTISSEPSFKNVISYLKEGDLLVANHTKVSKRRVYLRSKTKARIHEAMFLEEKESLWKCKIRNSKKLKMGEQLCDEKTKQILFTIERKEEEFVFLKPKHSLQEEDFQQIGEIPIPPYLKRNADSEDEIRYQTLFAKTPGSVAAPTAGLHFSENIFKTLKEKKIQFCTLELKVGYGTFQPLTEENFQNQKLHKEEFFLEESSAQMLNLAKKERRRIFSIGTTTLRALESAYDPVTNTFCSGPGVTELFILPENRLQSCQGLITNFHLPGSSLLLLVSAFAGKELILKAYQKAIQEKFRFYSYGDAMLILGIELIP
The following text describes a protein:
Function:
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
Sequence:
MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEIFICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQGINPYIPLDYELEHFDLPKFSYYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIEKIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKAIIVDDEFIDMPDNVDIESLNIKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYYNTKFRG
The following text describes a protein:
Function:
With S4 and S12 plays an important role in translational accuracy.
Domain:
The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
Sequence:
MRFNIDEWEPKTTIGRMVKEGQITDIDYILDNNLPILEPEIVDALLPDLEEKVLDVKLVQRMHKSGRRARFRATVVVGNRNGYVGVGKGKAKEVGPAIRKAIAQAKKNIIRVKRGCGSWECGCGTPHSIPYKGYGKCGSTAIEILPAPKGVGLVAGDVAKAVLGLAGIKDVWTKTFGETRTTYNFAMATFEALKSLNFTRTMEKHKEKLGIVEGRVL
The following text describes a protein:
Function:
Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Subcellular Localization:
Nucleus.
Sequence:
IMDTSSTSLADISLLLLADAAVPHYASAIVAALINVNQTLKTQVETIQADVRSIRESIEELKEMKREERRESEHHSHQRDQEAGEQNRSDAPNKRDLAFSVYLREMKSEPGETGGQRGDEEEEEDDDEEMNEEDEEDDDQPGPSAATAAAAAGHSLQQPDFSSMAALLMSSLPSLANQFTMNQMPTLSSSSSLQQQQPCSSSSSAADAAAAAREETATPGSSKRIILPCPRSGCEVLLYSQLGFSAHLRIHDGKMPFECTNCGREFRLRDGLVKHMRTHTGERPYPCQVTFKPVNEEQIKEIIIANTHNQAVIFKMKTTRPGVFKMKPVFFSLQPNTKVGKRKIKDQPIHRLQKSIKLHYSGCPDGVKPNLKDRFSVIMAIVPKDAPADMDVEKVWEDQKMQVELADSVRRKVLRIHYEGYEVPVDAPEKSEKKSKKGKKKGGSRDNSVEDAAAGHHKKFSAAAHTNAHGAGTPAVQPIVYIVYQGLPPREEVETK
The following text describes a protein:
Function:
Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
Subcellular Localization:
Cell projection, bleb.
Sequence:
MDPFTEKLLERTRQRRELLAQKMAERPTPTPRKRVLERMPLRETENVQDNQDEDSPNKKPRAHTTDQTETKTVAVEKLLGKSTGHGTAGLRSRMQELASQRRKWERGEASAEQEAPAVSSSEDQPLSPTPKPRAQPASGSSSSRGRFAHLAAKQSSWEDDTHNQGFGALHREEKKKQAPNAPAQSSVQKRQAPSIPKEEPQKKSANTGGGFWGGKEPRLSVSESKPVHKPTVKTTENKKPTPAPASDKPAPSSPFVSGRAALFDKQTPKQTPTRTVKETKPRTKTSQPPSKETNGEVVEEKPVSVRFAAQLFAAQEEKAKREAKKTWLVQKEKLKQPAKPAGNGRFGDRAPAKEPVRETTTTPAEQGTAAKKTAPATKSVHDRLREAAQNRQRENDPAAQMKKERAAELAQLKNRWEKWGVKKDEETPAEPKTESAAPCFTPWDKPKQRQQEPEPESEEDSEEEEMSGVEESSDKAKEPEVPSAEVEEDDDDDDEDDEEDEEKNTTKALDDLLDEVIDSPPVKNPTPPRKQEPSRQEKAKKVAFAAETTTPKIPKSSSAESVVPSSVEEVEERPLMYSLECYRSMRKSKSRPNAVKTIVRNHKPTISTSDDDDPAPSPEVPARPARRVPIKDKVKHLMEQVASQQTIVHQASQALNVCRDAEHGKGSAEEVEAERLLLIATQRRLALLAETQRLKNLGPDGEREESMEGAKPCRGTLTITDIKLPLKGEYLFSLKEGNVPGDDYFFCLIYNGPEKVIPTMMLSTADKIAGDSMWFTNHIVLNNINSNFDVKIEVYNMRMKRLKPDNQQKSALGSLLGMPSPKLKNLAPKKIFTNIMGKDNSMSPLLRSLGGPSTVRNSNFVLMGETHIRLCDVRKTQFTLDKVPFLSPLQGHVQVRIHCHMDSGVEERGFLTMFQDVGGFGSWHRRWCVLSNWRLAYWTYPDDERRKDPIGVIDVGQCITKNITTVSREWCARPNTIEILCSRPVKDDDKDTIVDSVDWKNKTVTTKHWISADTKEERIQWIAQLNKALTNLRMWSAKN
The following text describes a protein:
Function:
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MEDNQEIPDLSYGACLIGPPGSGKTSAIKALKEMCEKLSRHVIVMNLDPANDQLPYQADFDICSTINVKDVMATTALGPNGGLIYCMESLAENIDAVADVIRPRVQKASYFLIDFPGQVELYTHSECIRQFLDKFQKDLKLKLATVNLVDVVLASTKQGYLGQSLMSIGMMLRLYTPHINVLSKFDLVETGEVELPFETETCDFEDMVCSGTPSKLHQKIVELLCDYDLVSYEYFSVTDESSVMHLIELIDKAVGCSWML
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular Localization:
Nucleus.
Sequence:
MRDYIWQRMENDQGELADVVRAGGWVGASSTAFPASDWQLPSEPVVFPPASIKDSSSDLGDPFMKLCDPLIDELSGIEFFKSRETMAGQVNMVIKESDCGDGGGFISQKLLMGGGIKKPFDITSPEADKSSPLSPVMAGEMMKVSSGAVGCLGDDGGGGQQISSSLEQGVKRRKNEAKKVVCIPAPAAACGRPGGEAVPCDLWAWRKYGQKPIKGSPHPRGYYRCSSSKGCSARKQVERSRTDPDMLVITYTYEHNHPWPTQRNALAGFARSQTSKNCSTRNLKEEPKDTTRCSAASVKQEVKEVVDKVNDQAFYRSREPLISEQYHPDNFFTDMSVLEADTVNLIFSKELTETKPEENGDKALDPFNMFY
The following text describes a protein:
Function:
Required for the biogenesis of c-type cytochromes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Sequence:
MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIGITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLGLFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFLLKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMVYEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRKRISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPKEVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA
The following text describes a protein:
Function:
Probable transcription factor involved in the stress response.
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPEQAQQGEQSVKRRRVTRACDECRKKKVKCDGQQPCIHCTVYSYECTYKKPTKRTQNSGNSGVLTLGNVTTGPSSSTVVAAAASNPNKLLSNIKTERAILPGASTIPASNNPSKPRKYKTKSTRLQSKIDRYKQIFDEVFPQLPDIDNLDIPVFLQIFHNFKRDSQSFLDDTVKEYTLIVNDSSSPIQPVLSSNSKNSTPDEFLPNMKSDSNSASSNREQDSVDTYSNIPVGREIKIILPPKAIALQFVKSTWEHCCVLLRFYHRPSFIRQLDELYETDPNNYTSKQMQFLPLCYAAIAVGALFSKSIVSNDSSREKFLQDEGYKYFIAARKLIDITNARDLNSIQAILMLIIFLQCSARLSTCYTYIGVAMRSALRAGFHRKLSPNSGFSPIEIEMRKRLFYTIYKLDVYINAMLGLPRSISPDDFDQTLPLDLSDENITEVAYLPENQHSVLSSTGISNEHTKLFLILNEIISELYPIKKTSNIISHETVTSLELKLRNWLDSLPKELIPNAENIDPEYERANRLLHLSFLHVQIILYRPFIHYLSRNMNAENVDPLCYRRARNSIAVARTVIKLAKEMVSNNLLTGSYWYACYTIFYSVAGLLFYIHEAQLPDKDSAREYYDILKDAETGRSVLIQLKDSSMAASRTYNLLNQIFEKLNSKTIQLTALHSSPSNESAFLVTNNSSALKPHLGDSLQPPVFFSSQDTKNSFSLAKSEESTNDYAMANYLNNTPISENPLNEAQQQDQVSQGTTNMSNERDPNNFLSIDIRLDNNGQSNILDATDDVFIRNDGDIPTNSAFDFSSSKSNASNNSNPDTINNNYNNVSGKNNNNNNITNNSNNNHNNNNNDNNNNNNNNNNNNNNNNNSGNSSNNNNNNNNNKNNNDFGIKIDNNSPSYEGFPQLQIPLSQDNLNIEDKEEMSPNIEIKNEQNMTDSNDILGVFDQLDAQLFGKYLPLNYPSE
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
KNMSDKTAEKDKNETSDLGSLEEDDEFEEFPAEEWSAADKEPEIFWEENWDDDNIEDDFSKQLRSVLEQTGQMK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MAGVLFEDIFNVKDMDPEGKKFDRVSRLHCESESFKMDLILDINSWLYPMELGDKFRLVLATTLREDGCPDSGEYNPMEHEGTRADSFEYVMYGKIYRIEGDEAHNEASRLSAYVSFGGLLMRLQGDANNLHGFEVDQHMYLLMKRLAF
The following text describes a protein:
Function:
Is involved in generating a small heat-stable compound (Nod), an acylated oligomer of N-acetylglucosamine, that stimulates mitosis in various plant protoplasts.
Sequence:
MKQLRNNVIRAGLGALYFSGAHHLLRPLLSGVGAIFMLHHVRPAREATFQPNRHLEVTPDFLRATLSHLRSRDIDIVSMDELHERLVQGRFTRRFAAFTLDDGYRDNLDYALPVLREFDAPLAVYVASDFAEGTGRLWWTALEAVIARAEQIEVQIGNSALRLDATTPAAKQAAFDRLHDWLRALPGEHDLAREIAALCARHGVDMEALCHTLCLSWDGVKQLAADPLVTIGAHSISHCNLARQSEEIAAQEMAVSRTRIERVLARPVLHFAYPYGDREAAGMREFALAASAGFKTAVTTRPGMLFAENAGHMTALPRISLNGNYQDTRILPVLTSGAATAMWNGFRRIAAA
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
Sequence:
MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKTFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
The following text describes a protein:
Function:
Transcription activator of small-nuclear RNA genes (snRNA), which have essential roles in pre-mRNA splicing and rRNA processing. Essential protein involved in the establishment of apical meristems and organ primordia, embryogenesis, cell differentiation and cell proliferation, probably by modulating the establishment of auxin gradients. Participates in the control of competence in cell proliferation; required for the reinitiation of the progression of the cell cycle and subsequent cell proliferation during cell redifferentiation leading to callus formation, especially during the first day of dedifferentiation (e.g. callus, root and shoot formation from root and hypocotyl explants).
Subcellular Localization:
Nucleus.
Sequence:
MAMKEAFPEDYLSQEELEPSLNVSHHENPLAGRAKRKRTVKNTEVKKRTLKNTEVMKMTEKKTEEAYLVKVEQLAKLKQKQEEDKAAVTLHCFSKTSETGKDVVAPPEGFEQMQSLRFIDNNYTKLKPSDIQGQVDPLFPEVILCVEIYNSRKVKTQEFLVLGRQMLTELKDNIHCATDQVMQKAGKYDPSGYFLIEDVFHNDLRNPSAKDYSYPILDWLWNSKDEALKKWECVLTGELQKKQKLVLGEAKSVDLPRYRTADMQSTHFCDIRFRVGASYVYCHQGDCKHTIVIRDMRMSHPEDVQNRAAYPIMFWPKRRIQKCGVCKIKRASKVAVDDKWASENSSYFCDVCFELLHSEEGPLNCDFPVFDYVHE
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKDILKTGLILMVFTAISGLFLGLVYVGVKGKIQEADNAAKLSAIKFVLKDPLTGDYLVDEKEIEEIVKKTGIETVVLKEYKEGVVLGPLYEFVTKDGRNAYVLSGYAPGFGGNVTVVACFIKTEDGFMLNSVRVIDYSQETPGLGAKIGEESIQRRFFPVPPEGLKNGLRVDKDAGLPKGSPEELKKQGIVKVSDVMTGATITPRAVVTALNLMYRYLEEVSK
The following text describes a protein:
Function:
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
Subcellular Localization:
Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Localized at centromeres in both mitotic and meiotic cells.
Domain:
The C-terminal histone fold domain is sufficient to direct CENH3 to centromeres.
Sequence:
MARTKHRVTRSQPRNQTDAAGASSSQAAGPTTTPTRRGGEGGDNTQQTNPTTSPATGTRRGAKRSRQAMPRGSQKKSYRYRPGTVALKEIRHFQKQTNLLIPAASFIREVRSITHMLAPPQINRWTAEALVALQEAAEDYLVGLFSDSMLCAIHARRVTLMRKDFELARRLGGKGRPW
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKLVWKICSIFTAVVVVWILLLLAKDLASSVHLIVPYISMFVIMSLGCCRLGVLSYGMMVFRFCVEEEILLQKDIEEQKHFSRSVVLS
The following text describes a protein:
Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
Subcellular Localization:
Cytoplasmic vesicle, phagosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome.
Sequence:
MTLHFLLLTSLFLLISDSCEFFTEASYPRSYPCDVKNENGSFIAECNGRRLQEVPQTVDKDVTEVDLSDNFITRVTNESFQGLQNLTKINLNHNAKSQSGNPAVKKAMTITDGAFLNLKHLRELLLEDNQLQQIPAGLPESLKKLSLIQNNIITLTKKNTSGLGNLESLYLGWNCYFACDKKFTIENGAFQNLTKLKVLSLSFNPLHSVPPSLPSSLTELYLSNTHIGNVSEEDFKELSNLRVLDLSGNCPRCFNAPFPCVPCQGDASIQIHPLAFQTLTQLRYLNLSSTSLRKVPASWFDNMHNLKVLDLEFNYLMDEMPSLEILDLSYNYELKKYPQYINISKNFSKLISLQMLHLRGYVFQELRKEDFEPLRNLSNLTTINLGVNFIKQIDFSIFHWFPNLKIIYLSENRISPLVSDTEQHDANGTSFQSHILKRRSADIQFDPHSNFYHNTRPLIKTECSRLGSALDLSLNSIFFIGVSQFKDFGNISCLNLSSNGNGQVLNGTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNAHYFRIAGVTHRLGFIEHLTNLRVLNLSNNDIFTLTETQLKSASLGELVFSGNRLDLLWNAQDVRYWQIFQNLKDLTRLDLARNNLRNVSSQAFLNLPQTLTDLHINDNMLKFFNWTLLQQFPRLELLDLSGNQLFFLTNSLSTFASSLETLLLSRNRISHLPSDFLSGASSLIHLDLNSNQLKMLNRSTFETKTATKLTVLELGGNPFDCTCDFGDFLEWMDRNLNVRVPRLTDVICASPGDQEGKSIVSLDLSTCVSDTIAAIFCFLTFSVTISVMLAALAHHWFYWDAWFIYHVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVMNELRFHLEESEDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTKKYAKNWNFKTAFYLALQRLMEENMDVIVFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQSLKNVVLTANDSRYNNLYVNSIKQY
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MDSEIKNIKKWNIMYPIYINSKKTIAEGRRICVTKACENPTVTEISDCCNYLKIPCAIELDKAYPRDFMQRGRVRVLLKKEDGTPYNPAISSRKQLMIHVAELVRRHPNRTKKQEPASSSAAGSSKSGKGGKKKR
The following text describes a protein:
Function:
G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQVSFTEASDVSNTSSETLNLTLTNCTSTNSSAEIEDEYALESFYTSFKMEQLITLWILFIVTIFGNSVVLFLTWKERKRKSRMTFFVTQLAITDFLTGIISITVNIIWRITGDFMAPDIVCKIVRYLQVVLLYASTYVLVSLSIDRYHAIVHPMKFLQGEKQAKVLIAVAWTLSFLFSIPTFIIFGKLKLPNGEIQCWAIWPDDSYWIPYMTIVALLVYFIPLIIISVIYFIVIRTIWVKSKAHTVIISNYTDGNFCTSYSHRGLISKAKMKAIKYSIVVILAFILCWSPYFLFDILDNFEMLPETKERFYASVIIQHLPFLNSAINPIIYCVFSNRHCRLSRDRNSAKLGGTMRDKTEGIEMQVVSRPEYL
The following text describes a protein:
Function:
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Miscellaneous:
MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame. Expression of these 2 proteins are related since a mutation that removes the start codon of the small subunit (MOCS2A) also impairs expression of the large subunit (MOCS2B).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MVPLCQVEVLYFAKSAEITGVRSETISVPQEIKALQLWKEIETRHPGLADVRNQIIFAVRQEYVELGDQLLVLQPGDEIAVIPPISGG
The following text describes a protein:
Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
Subcellular Localization:
Nucleus.
Sequence:
MSGNNNNPQKPQGSAPLPFGNPGMASASVPGNQGFAQSHMAANFQAQFQFSQAQALAHAQAQSKVQAQLQAQLQAQGMTMNQAQGSPGIGGLGPSSPSLTTPGSLNMKRFQQKPPMRPPGAPASNNTISPMRTMELTPAARKKKQKLPEKSLQERVAAILPESALYTQLLEFESRVDAALTRKKVDIQEALKNPPCIQKTLRIYVFNSFANQNNTIPGNPNADPPTWTLKIIGRILEDGVDPDQPGFVQKANPLHPKFSSFFKRVTVSLDQRLYPENPLIIWENARSPAPQEGFEIKRKGNQEFAASIRLEMNYVPEKFKLSTALMDVLGIEVETRPRIIAAIWHYVKARKLQNPNDPSFFNCDAALQKVFGEEKLKFTMVSQKISHHLSPPPPIHLEHKIKLSGNNPAVSACYDVLVDVPFPIQRDLNNLLANAEKNKEIEACDEAICAAIRKIHEHRRRRAFFLGFSQSPVEFINALIESQSKDLKVVAGEASRNAERERRSDFFNQPWVEDAVIRYLNRRPAAGNDGPGSW
The following text describes a protein:
Function:
Required for the conversion of the yellow polyketide pigment synthesized by wA to the conidial green pigment.
Subcellular Localization:
Secreted.
Sequence:
MYLSTVLFPLLALNLGLSHARFVRETLELTWEYGSPNGGTPREMVFTNGEYPGPDLIFDEDDDVEVLVINNLPFNTTVHWHGLEMRETPEADGVPGLTQTPIEPGATFTYRFRAYPAGTFWYHSHYKGLMQDGQVGAMYIRRKPDALRPYAVITEDPRELAEIQYAEDNPYLMLATDWTYLTSAEYHNIEVESGYNVFCVDSLLINGRGSVYCPGYQYLEEVSDDGLTAVLEGTHLTEKGCLQPDLHNVQGDYGPWNLSAVPTEVVFNCTPSSVEPPVIYVDPEFNGWVSLNFIGGAAQKAITFSVDNHPMWVYEVDGQFVEPREVEMVGVYSGARYAVMIKLDQTPGDYAIRIAVNGGDQVMSVYAILSYVNQDWIHRENVPKAAIGPHTDTVGYMNYGGGNTSADVRQLLFTENLPAFGVPPPPPSSEVSTTLRTGMIRVNNSYSWSLGNNVLYEPEMTSSTPLLFEPDPLAVIAPKYALTTENNTWVDIVLEITADPRDLIHPPHPIHKHGNRAYIIGNGVGKFRWENVSAAEAEVPDLFYVNETAALRDTFVTDFFDSRLMDGAWIVIRYFVQDKFPSILHCHIASHQMGGMALALLDGVDVWDS
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MEAAAAAAGVQLGTSKPQIATQAEMAEARLPIPYRDQCAHLLIPLNKCRVAEFYLPWKCEPERHSYEKCQYELVMERMLQMQKIREAQAGAKVKGSVTIGVPLAPSTAKLA
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MIGFEWLEIQYRLITVLAFLSLFCNVILIILIYLKSPKKLGPYKHLMTFISIFEICYSIIDYLVVPVMHSYGTSFFIMTPLSHSLFEKPVSLIMLGVWCAFYGSSMALFGIHFIYRYLAVSGNKRISTFKGFKIVAWLIVPFIFGTIWGTISYFCCGPKAVTTNYIRDNLMQEFSLSVEDVTYMGPYFFNENGGFLFDTDVVMTLVGATSIMGTSLMTIFFYGWKCYKALSDVTTSGGFSKQYRALQRQFFLALVLQTVIPITLMHLPLLITYSGALFNVGLGRMSSITSITIALYPVIDPLPSIFIIKNYKEGLKKFLMTPVKFCLTVKNKKAVNVAHIDGTSSRRTSKLPDDDNVSVWGEI
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MAKRAYKLQEFVAHSSNVNCLKIGRRSSGVLVTGGDDKKVNMWAIGKPDSIMSLTGHSSPIECVTFDLAEEIVVAGAAGGTLKIWDLELQKVVRTLTGHRANCISVDFHPYGEYFASGSLDTNLKIWDIRRRGCVHTYKGHTGGVRCVKFSPDGRWLVSGGQDNSVKLWDLTAGKMMHDFTLHDGPIHDLTFHPHEFVLATGSQDRTTKLWDLETYELIGSAGPETTGVRNVFFTPDGRTVLSAVQDNLKVWGWEPVVCHDTVDTNWGRISDMALHEGKVIGCSIQQSTVGVWIVDLSRVAPFSAGAQSKAAPKPISRPATEIRPVSNGSDNGSQVASRESSQQSSRATTPAKPISRARTPPDSAEQVFSSPSVHAGSASSPPPAKAADFYAPRASPAAASGARQAGSVIATPPRGSPRPGADVSTAPLPSDRSEKRELQRTPPRRREEATPRGEKGNGGSSSLPRGEDRDPMGEAAASGSGRTEEGTEGGVNVKHNNGSVTDRSAPKDYERPSQPNSSADDTGQKAGIGRRVSRAEKKEIEFEILAPAGPNPHRTSEADAAGVPTSAEPVRAGGKRRSGLFKPEDHDIFGPTRTADGAGLSGRDSDAVVRSENGREAEGAVPSGRGKSPRGEKETKSVAIAAPGDSLMRGAALPGAALSTPGPSGREPPFSHHTPASNGGSRARVDALSALSALARSPSVTGDRSRKEGPLGLDIKAFLPKSASKLAPDGDAASVSDAELIESLMGQHATMSTIMQSRLTNLAVVRTFWARNDLKGAIEAMDKMADHALLVDVLGTMAHRSDVFSLELAAQAMPLLGELLTSQHDRYVLVAIAVAASLLKSFGSLIKEARQASPAVGVDLSAEERLERCNACYRGFLVLRGKLEGLARTSGEVGKMSRELIFELEELQ
The following text describes a protein:
Function:
Catalyzes the deamidation of nicotinamide (NAM) into nicotinate. Likely functions in the cyclical salvage pathway for production of NAD from nicotinamide; Is also able to hydrolyze the first-line antituberculous drug pyrazinamide (PZA) into pyrazinoic acid in vitro, but this reaction is not considered to be physiologically relevant.
Sequence:
MPPRALLLVDLQNDFCAGGALAVPEGDSTVDVANRLIDWCQSRGEAVIASQDWHPANHGSFASQHGVEPYTPGQLDGLPQTFWPDHCVQNSEGAQLHPLLHQKAIAAVFHKGENPLVDSYSAFFDNGRRQKTSLDDWLRDHEIDELIVMGLATDYCVKFTVLDALQLGYKVNVITDGCRGVNIQPQDSAHAFMEMSAAGATLYTLADWEETQG
The following text describes a protein:
Function:
Facilitator of innate immune signaling that binds cyclic dinucleotides produced in response to infection by bacteria and/or viruses, and promotes the activation of the NF-kappa-B transcription factor Rel (Relish). Recognizes and binds cyclic di-GMP (c-di-GMP), a cyclic dinucleotide messenger produced by bacteria such as L.monocytogenes, leading to activation of the peptidoglycan recognition protein (IMD) signaling pathway and activation of Rel (Relish) (By similarity). Innate immune response is triggered in response to double-stranded RNA from viruses delivered to the cytoplasm: Sting acts by specifically binding cyclic dinucleotides 3',2'-cGAMP and 2',3'-cGAMP produced by cGLR1 and cGLR2 in response to RNA virus in the cytosol. Has a strong preference for 3',2'-cGAMP compared to other cyclic dinucleotides such as 2',3'-cGAMP or 3'3'-c-di-GMP. Upon binding to 3',2'-cGAMP, activates an antiviral immune response, leading to the activation of Rel (Relish). Activated in brain in response to Zika virus infection, leading to autophagy (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIKEMAIANNADEVDNEVRAEKGRKCFYLKKMIGDYIGNTVRIVATVVLADFLQRLYRSVVEYVHCSKYYLPEDRLWTILRRSCTYSNKSRYLVMGFILIGFLRISVSGNYKDVVPTFKFLAYMPLYWIFSNLGHSTLTYSSWVRDSHGLDYAAGMASNYFHGYLKLSLPERKADGLLHRMNVYEDKYNVTFGIKRLIILIPDEMFINGVIQSRILEKATPLETQFINRAGVNRPFKHAVYRLAEKVNGKTYYFAMEGATPMLSFFEAMHSNFSATWQMKELKREIWLKFYTHLNELIKTWPETRNLVELIIYNSHDTKGDLVDVGEMLKSHMELKTKNIDEMIG