The following text describes a protein:
Function:
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere. Note=Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks.
Sequence:
MCVIQRLTYAYLIRTSLNDKACHKIFESLFRFISVERSLYNRASSKGACASRLSACASVIRTAINVFLRNLRTKSIRAIVDHITEILQVPGEGLWEHLGADYLKCLTTLLRYPPHLEHLAANEWDKVLNLCLRSIGAPEDGDSQSSDHNGHPSTLDDFLDASSRSTPSRRTSSLALREKQSGDKRIVAEAIVCIQLLTATPTAPVQVAAEKVLRGLGTFLKLSPIAGSEHQAAFNSINTVVMRVIFDQSDLVRMFLLDLIPVIRHLWSTKLMGLKDELLVTILLCMIILTDATRRAPTDSLALSIENLLDTIYSEYTKRSEKDILQIDELIFDRTSFTQIIDLALQPRLEVPRSEHNLTVVWVMAKLMRLSEESTAQLSHPAGETPSKKQRLNSASDQVFRDCVMSSGNRRVCALQLIPILLQGRLTMESKASLLQRLIPYILDDNGVIASWTMVAISSISDSSLELWAIITRLCAQTNPGSVSNASKQICSWLREAWVIGTVTDRIQTAQVAAFARPLDLLNLFLACTNRQFEMPTPQFRGPSGIVAKGWHFYQSNRELLHYLFHVDGMLVPSSLHGRDDCISLQLATRKDHNDDIVLDLLQAKSEMFLQAWRSVSDSKSHHVTVDVVQILASFCIVAVLYTECIPEQLHTQIKDLRGNIQQLWDSLCSFMASRELVFVQYCLELLCPFLPQGGRVGFEKSVVNSSLYRLVSPLGAILENHRQDQKRLLSSDEEEPMDLDDQLLQSNDLLAENMCIINSNRESVPLFHDSATFQRSMTIRLSIFNIAYGSVVQPDQPARSALVEYLTDLDEADILSSKDFLPDVYRACAGYERTSLLDLLEDMGEKCLQTYQLERCETSQVLCIHMLDSFIKSWTTGDGDHLSDSASDIYNWVTDVLLVNGRASSRVSIAFSRLLEEIFSTNPAYTSGESNPSPRTTLFMILQESDILTKYNVGNLVPKLFRHFPLKDHDAIFDDILESLPRDPDWTEGIALRLFILARLASQWHTLLRRSIYHMFETPAQLPHSRWHAEKCIRHVASVFGLEDARQLFRLFSSQILYTWTENESVMTMPFSIFGYSTLEDMLSDVQDEIVGQIMMRANEHEASELSTRLKIPFIELLATSFYKAEAYSIARDISTPPGQSSQPKGVENRLKKILGADRFVSLVEKQFPQVIATFFGTLDQCEQIERAFSKRANFQEAFSILKSITAKGASKEILPPNQQPSFRARYLLDELEFLCKRSGYELETIWTPTLASYVCRTLLESIHPALGSLHACSVIRKIRILICITGPVMLRDYPFEMLLHALRPFLTDIHCSEDALGMFWYLLDAGRSYLTENPSFTAGIAVSTLLSFRKFLASTSATMQESESVAVLTIVQTFLQWFEDYLKSYESPHLSPEAHAFFQRLMESSRRISTPDKELDGTEECNLLLEVIQDRNSKTRLLSQSISDHILSLLCASFKSAPNYHQGLVERGYDAIADSVALYQTLQDFSPTKEYRLWAARVIGRNFAATGMISDDLLREQQSTLFEPRMAKLSLHMSCQSKARILQVLCSMLQNSSPLEVGLVERTLQLIVSNLAGAPGFENYEEIISPSLLKALIWSPYQCPSIPLPASQTKNHDTIVRWNPGISFAHWARSIGLFLTKAAPQDPVIGPLRNILHVIPSLAVRILPYILHDVLLTEPDGVANVRKTISDVFQQGLHEADAHSIPHVRLIINCLLYLRNQPRPQEATIVERDEWLEIDFAVASRAANTCGLPKTALLFLEIQASRAVSGSRRSSLVKYEPPPDLLHDIFRNVDDPDLFYGVQQSSSLESVMETLEHESSGFKNLLFQSAQYDCEIQMSGDADAHGLLKALNSSNLQGIANSLTSTLRGSKSSVSFDSMMQAAIDLRQWDLPVSPMNHSPSAALFRTFQSLNTSTSLVDVSNSVNESLLAILGSLGSTSRSAMSFRAAMRDLGIVTEISDVLSATSLEELSEEWRKIAERNSWLKATSVDEVGEILKCHEALFSSIKTRDYLKSAVGLSDRDAQLLEVKVIRQSLSITRSHGIPQVSLKSAMRLSKLADLCVVQGINVEGATKFDLANVLWDQGEMAASIRMLQQLDNQGDLHKQAIPISRPELLVTLGHHVAEARLEKPEAIIQGYLGPAVKELKNRSEAEEAGRVYHGFATFCDQQLQNPDGLEDFRRAEQLRNRKEKEVLGLEEMMKNAEGKEREALRHYRTKTKQWFDLDDREYQRLRRSREAFLQQCLENYLLCLKESDMYNNDALRFCALWLGKSDSEIANKAVSKYLNQVPSRKFAPLMNQLTSRLQDTSDEFQNMLFALIFRICVEHPFHGMYQIFASSKSKGGKDPSALSRNRAASRLVDCLKNDKRIGPTWVAVHNANISYVRFAVDRLDEKVKSGAKVPLKKLLTGQRLEQDASTQKLPPPTMKIAIRVDCDYSEIPKLVRYHPEFTVASGVSAPKIVTAVATDGHKYKQLFKGGNDDLRQDAIMEQVFEQVSSLLKDHQATQQRKLGIRTYKVLPLTSNAGIIEFVPHTIPLHDYLMPAHQRYFPKDMKPNMCRKHISDVQTRSFEQRVKTFRQITEHFHPVMRYFFMEKFNSPDDWFSKRLSYTRSTAAISILGHVLGLGDRHGHNILLDERTGEVVHIDLGVAFEQGRVLPVPEVVPFRLTRDLVDGMGITKTEGVFRRCCEFTLEALRQESYSIMTILDVLRYDPLYSWTLSPLRMKRMQDAQEAGDGPPMISGAAEDQRSANEPSEADRALTVVAKKLSKTLSVTATVNELIQQATDERNLAVLYCGWAAYA