lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MEEIMIQSIDESIHCGLIKNALFLSERLYASTANEDNLFKIAQIYYQMGKINQCLLILQQHPQITMIKNLYLLALSNYDLGNIQEAESSIIKCCIYFEKYFQPNNNNNNNNNNNNNNNNNNNNNNNNNKDKCNNSNKNNDSNNNSNSNNNENEYYGIYSDILCEFDDIVDINSISYGFDSPCSIGSVYYLMGLISKRKNQKEKAIKYLKKSVYTYPFLWVAFEQLCNICPDEIDISDLFSHTNLIHQINHLNQQQHQQHQQFQQYLSNSLNQNKVNNNNNNNNNNNNNINNNNSSNKNNEQTITSTVATGTTNITTNTIKPNNFIKPPYHPNHRVGLTPSSFYDSSIHITPINFKASIQQTNQQQQQQQQQQPQQPSQQNLQKYNNRYFVTPQTPLSHITPILSNRFSQNVVDPIPMVMDTPDSKGSQHPPSSNSQTPYTPSTPGVHHHQKQQPHQHKKSAPPSQMIKKSMSNEFDTPMSLDLKSPIFTTSTSSDVHGFTSSTSKQQQQQQQTKQQTTTTTTTTTSITDKEVLLTKTKKQVNFGKTEEFSLKSLSSSLSDDDYDEENHHYQQHHHLHHHNKSIDELELEEDDQLNITDNSVQPNFYEFDESSILDFNGGDLYEGLIELHKGQTQLLELFFILADSYRLLCLYLCKEAIESFKRLSEEQYRTGWVLTKVAKAYHELIDYKEARSIFQEVSQMEPYRLEGMELYSTLLWQMNEDAELSYIAHKYSEFDRLSPYSWVVVGNCFSLQRDHEAAIKLFRRAIQLDPDMTYAYTLCGHEYLANDELELALNAFRMAIRCDPRHYNAFYGIGLIYYRQEKYNLAEYHFRKALSINESSSVLCCYLGMTLQHNPNKIQDGIDMLYRSIEIQPKNTFAKFKLAAFLFANQQYHHAIDQLLEFKEIEPKETPIYILLGKCYKQLGELDKALDSLNTALDLDPKNSNYIRSLIDKLPLEDEDDNQDYFQLN
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MATTARLISVALLWILVLFVTLAFIQNRLSDGGVSSDPKLNYSRLSQKEIKLEEEDLEAVTHKVYFDIEIDGKSVGRIVMGLFGKTVPKTAENFRALCTGEKGKGKSGKHLHYKGSIFHRIIPSFMIQGGDFTRGDGRGGESIYGEKFADENFKLKHTRPGLLSMANAGKDTNGSQFFITTVTTSWLDGRHVVFGKVLSGMDVVSKIEGQGNQSGVPRHKVVILDSGEMPM
The following text describes a protein:
Function:
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions.
Subcellular Localization:
Cell projection, cilium membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
Sequence:
KVCTMSGNRWLDDDDINPSSGGVNKWGGNDGYEDFDPNKDYFTQVVKRKENNILESTQRSLRMLDESERVGVATGQELVRQGEVLRRTEKTVDKMEQDLKESDRHLRSIKSVWGAFMNKFSKEPPAPKSMNAGTEFDAGTSNNLENVMRKCEDVEDERRQNEEHPVIARQQRAQQMYMDGGRDESSSQNKMNQVEENLADLMGQSLSRLKQLGLGMQNEIEAQDPIIERLHGKVNKVDDKIHSTNKEMMRLN
The following text describes a protein:
Function:
May suppress the RNA sensing activity of RIGI in a GTP-dependent.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVAGGRALSRGAELRVPGGAKHGMCLLLGATGVGKTLLVKRLQEVSSRDGKGDLGEPPPTRPTVGTNLTDIVAQRKITIRELGGCMGPIWSSYYGNCRSLLFVMDASDPTQLSASCVQLLGLLSAEQLAEASVLILFNKIDLPCYMSTEEMKSLIRLPDIIACAKQNITTAEISAREGTGLAGVLAWLQATHRAND
The following text describes a protein:
Function:
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
Sequence:
MSDILNVSQQREAITKAAAYISAILEPHFKNTTNFEPPRTLIICGSGLGGISTKLSRDNPPPVTVPYQDIPGFKKSTVPGHSGTLMFGSMNGSPVVLMNGRLHGYEGNTLFETTFPIRVLNHMGHVRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLALSDAYDLELRKLLFKKWKELKIQRPLHEGTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVIVARHCGWRVLALSLITNTCVVDSPASALDESPVPLEKGKATHAEVLENGKIASNDVQNLIAAVMGEL
The following text describes a protein:
Function:
Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity). Also has an N-acylethanolamine hydrolase activity (By similarity). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity).
Subcellular Localization:
Lysosome. Secreted. Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent.
Sequence:
MPGRSRVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELMLDKAPMLKVIVNSLKNMINTFVPSGKIVQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLSLNERFSINGGYLGILEWILGKKDAMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
The following text describes a protein:
Function:
Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling. Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (By similarity). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance.
Subcellular Localization:
Secreted. Note=Circulating DAND5 may be uptaken by endothelial cells and transported to mitochondria.
Sequence:
MLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSWKAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQVFSRPGCSAIRLRNHLCFGHCSSLYIPGSDPTPLVLCNSCMPARKRWAPVVLWCLTGSSASRRRVKISTMLIEGCHCSPKA
The following text describes a protein:
Function:
Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Acts by binding directly to the promoter of natAB.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVKNGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMKPYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTTAEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKAMITKQQLDYFQNYYF
The following text describes a protein:
Function:
Dipeptide epimerase with a preference for substrates containing a Glu residue in the second position. Catalyzes the epimerization of L-Ala-L-Glu, L-Ser-L-Glu, L-Thr-L-Glu, L-Val-L-Glu, L-Gly-L-Glu and L-Thr-L-Glu (in vitro). May play a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component.
Miscellaneous:
MISCELLANEOUS: Part of a large, functionally divergent protein family. Protein modeling and substrate docking were used to predict the substrate specificity, prior to biochemical analysis.
Sequence:
MSKIIDIKTSIVTIPLKRTFVTAVRSTNHIDAVVVELSLDNGNKGYGVAPATTAITGDTLQGMQYIISEIFAPVILSSNLSDYKQTLELAFKKVMFNSAAKMALDLAFHDLLAKQKNISVAKLLGAKNNIIETDVSISCGSVAETIQNIQNGVEANFTTIKVKTGADFNRDIQLLKSLDNEFSKNIKFRFDANQGWNISQTKQFIEELNKYSLNVEIIEQPVKYYDISAMREITKFSNIPIVADESVFDAKDAERVIDEQACNMINIKLAKSGGILEAQKIKKLADSVGIPCMVGCMMESPAGILATASFALAEGITVADLDPLDWVAKDLYSDYITFNEPNIIIKDNLKGFGFSF
The following text describes a protein:
Function:
Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP; Involved in cell filamentation induced by cyclic AMP.
Sequence:
MSDKFGEGRDPYLYPGLNVMRNRLGIHQAQRLAQAAYEMTALRAATIELGPLVRGLPHLCAIHRQLYQDIFDWAGQLREVDIYQGDTRFCHFAYIEKEGNALMQDLEEEGYLVGLAHEKFVERLAHYYCEINVLHPFRFGSGLAQRIFFEQLALHAGYALSWQGIAVETWKQANQSGAMGDLSALRAIFQKAISEARETE
The following text describes a protein:
Function:
Involved in nuclear pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRNVDKANSVLARYQELVAENTSGYKDYSRFKRPTAVHRISNLEEAQRWRAEVVKDIGNKVTQIHDPSLNEMQIEDINNELNRLFQEKMRWESHIRRNLRGPDYRRMKQGLNTTGGTVINGTRYFGRALELPHVQELLQQQQQQRVKQQNQKQREQELRAKVRQWEEELGPDYYGEDVPPGMQEYEAQRSRELQDILRSAAGRAPQVQIPLFERLPTQEEVEGWLVERRRKRLQERLDL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.
Sequence:
MAPLEKDLRELLQANPHYAHVRYPDGRETTVSTKHLAPKDLKLKPDSCNGLKISLGEELHMRLQMTSDNGTDVMDRETLMVKEERNSLQAVTLNLTCRTCENPILSTVRFSRVLDLPSESWEQLSKDLCCHGTSLSEAYTSLNPSQDDCLLGSYYIVVHPSSLEEKNIIIKQGETTIDCGRCRKSLGKLIIQQQYPGRADVSGIQLNKHCIISRNSDVFKNYSFETYITRCLKSKLQGKVNFKFCLQSHHGGKTKTHALLWLMNSDAAIVSNLTPGINTYGFHPKEEKRKNGKNSKSENKASLTNVMKILYKALPKNMSSKAGTVETLSLPEQDCLQLLLLLAKSTLSIPPSLRHVTGYTVGFLRT
The following text describes a protein:
Function:
Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Required for the recruitment of MEC1 to DNA lesions, the activation of CHK1 and RAD53 kinases and phosphorylation of RAD9 in response to DNA damage. Required for cell growth and meiotic recombination.
Miscellaneous:
MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks. The recruitment to DNA lesion sites requires the presence of the RPA complex on DNA.
Sequence:
MRRETVGEFSSDDDDDILLELGTRPPRFTQIPPSSAALQTQIPTTLEVTTTTLNNKQSKNDNQLVNQLNKAQGEASMLRDKINFLNIEREKEKNIQAVKVNELQVKHLQELAKLKQELQKLEDEKKFLQMEARGKSKREVITNVKPPSTTLSTNTNTITPDSSSVAIEAKPQSPQSKKRKISDNLLKKNMVPLNPNRIIPDETSLFLESILLHQIIGADLSTIEILNRLKLDYITEFKFKNFVIAKGAPIGKSIVSLLLRCKKTLTLDRFIDTLLEDIAVLIKEISVHPNESKLAVPFLVALMYQIVQFRPSATHNLALKDCFLFICDLIRIYHHVLKVPIHESNMNLHVEPQIFQYELIDYLIISYSFDLLEGILRVLQSHPKQTYMEFFDENILKSFEFVYKLALTISYKPMVNVIFSAVEVVNIITSIILNMDNSSDLKSLISGSWWRDCITRLYALLEKEIKSGDVYNENVDTTTLHMSKYHDFFGLIRNIGDNELGGLISKLIYTDRLQSVPRVISKEDIGMDSDKFTAPIIGYKMEKWLLKLKDEVLNIFENLLMIYGDDATIVNGEMLIHSSKFLSREQALMIERYVGQDSPNLDLRCHLIEHTLTIIYRLWKDHFKQLREEQIKQVESQLIMSLWRFLVCQTETVTANEREMRDHRHLVDSLHDLTIKDQASYYEDAFEDLPEYIEEELKMQLNKRTGRIMQVKYDEKFQEMARTILESKSFDLTTLEEADSLYISMGL
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MAYRRRKKKIKKCRLCEMKLDYVDYKDTRLLSEFLTDKGKIIPKRLTGNCSKHQRMVKVAIKRARQMGLLPYLKI
The following text describes a protein:
Function:
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function; Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
Domain:
The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.
Sequence:
MSKVKSKFVCQVCGYESVRWFGRCPNCQSWNSFIEITEKKQGFNNRESKENLGVYRLEDILNYEPVRLKTGLTGFDYVIGGGIVEGEVILLAGEPGIGKSTLLLQLAISLDKNDTRVLYISAEESLSQVGLRLRRLNSGDKLNIDFVSERDIENILPNLENSNYSLIIVDSIQTIYSSEFPTSPGNVVQVRECTSKLVDFAKKNNIAVILVGHVTKEGDIAGPKILEHLVDAVLYLEGERYHDLRILRVIKNRFGPTNDFILYEMKENGLFEVEDISAKVIENRNTNVSGSIIIPIMEGTKPLLIELQTLVSRTNTSYPRRITSGIDLNKLVLILAILEKKLNISFSDKDVFVNVVGGIKISEPAIDLGLAFALLSALINKPFPSDMVAIGEIGLGGEVRTVPHIERRLKEAKKFGFNKALIPKDSKVKSYEYNMNVRTITDIGEGIDLVWGEKWRS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTVRSVYNVIDLLYYILKMYGLAPYTRRKNQGGSYVYVQCKPSRKYLFSILGFVVSLLGLGMVIFQVNQEQEMDTLEKTLYVGIIVQLVFNSAIIRVTFARKIGQFFETLEILNLIDKTLSQIGVQISYKFIQKFSSVFVAIYILHPIFTCVHIYDQRDTLLTFGEYFGFGVPLLTFQISLIIFLIYSVTLWNRFALINQQISQLNSHNFTKIFVKRRIVLFSDLHQRLCKATLFLTECLSPGLLTMYLQFLQMFTILMLIVLNVGLPSYKADAMTWTLLITGENLAMAIIIELIIYESEKTFRVLIDLENYHRDRNTELKVNTFLLQMLHQKISFTLGGLFEFNLNKLLQSVGTVTNFVMFVLQIKHN
The following text describes a protein:
Function:
May control the interaction of photosystem II (PSII) cores with the light-harvesting antenna, regulates electron flow through the 2 photosystem reaction centers. PSII is a light-driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating a proton gradient subsequently used for ATP formation.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MTIAFQLAVFALIITSSILLISVPVVFASPDGWSSNKNVVFSGTSLWIGLVFLVGILNSLIS
The following text describes a protein:
Function:
Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTGSSPPLSCQQVDNTLHIPALSCRGGFDFSLLFEELILGILPLGIVLIIAPFRLYHLFWRQAKVVASWLLWAKITAWLALGIVQLVLAVYWARPAATRTQASIAANAIITVGFFILCLLSCAEHLRSTTPSFLLNIYLLFTLLFDIAKTRTLWLRSSGQTDETIAILTSVTVGIKFLLLILEAVEKRHILRKGQSGYPPEATAGIFNRSFFLWLNPLFRSGFSKILDVEDLFDLDKHLSSRRLYSTLETLWDKVPKKNPNTLLFISLKAFKWPLLSAVPPRACLAALNFCQPLLLHRSLAFATEPVNNHTNSIGYGLIGAYILVYIGMGVTMGQYQHMTYRTITMVRGGVVSMIYNKASRLGIKDADPAASLTLMSADIERIVQGWQTIHDIWGNAAEIALAIYLLERELGVACVVPVGVALVALIGCLITLSFVVARQAVWLEAIERRISSTASMLSSMKGIKMLGLKSAIMKSLHGLRLEELEISKKFRRLLVWNMALGWTTRIFAPIFALGAFYGIMHSRGKDSAFDMSTAYTSLSLFALLADPLLSLVMALMTFVGSIGSFSRIQEFLEKDDHVDCRLKPLHASYESFEPKAMVLVDDSDATETASDRSIHRGKSVYHDALTVKNATFAWNVEKEPVLKGLTISIARGSFTMIVGPSGCGKSTLLKAILGEVPCVNGEIRLSSDSIAFCDQIPWHMNATIRESIVAMSSFDKEWYASVVHACGLVQDFEQLPRGDETVIGSKGIALSGGQSQRIALARAVYARKDIVILDDAFSGLDAATEDYVFHSLVGIHGLLRKINSTIIVASSSAKRLPYADQIVVLDKMGYASEQGSLKALNAAGGYVSSFGLGSPEWKSEIDKPSVTDLAQPKILRPNRTEAIKEDPRRQSGDLSIYLYYIRSIGWLPTRLVLTDMTGIWVKWWAISNEEDPNGRTGYYLGIYAMLGAVGMLSLIIGCWEMVINMVPKSGESFHRKLLATVLNAPMSFFAATDSGSILNRFSQDLQLIDMELPVAAINTFATLILCLAQMILMGIASRYAAISFPLVILAVYSIQKVYLRTSRQLRFLDLEAKAPLYSHFSDCLNGLVTLRAFGWQPALEDKNFQLLDYSQRPFYLLYAIQRWLTLTLDMVVAAIAVILIVLVVTLRGTISAGDVGVALLNVILFSQSIKLLVTFWTNLETHIGSIVRIRSFTETVSSENLPTEKDDVPPNWPWGGDIEFKSVSAEYRPSEPVLGDVSLTIKSGEKVGICGRTGSGKTSLIMSLFRMVELSSGSIHIDGVDITKIPRQEIRSRINGVSQSPLLIKGSIRRNMDPNGSYAEKAIIEAIKSVGLYTKIQEKGGLDTDISEVFLSQGQQQLFCLARAILRPGKVLVLDEATSNVDAKTDEIMQRVIREKFCTHTILAVAHKLETILDYDKVVVLDAGRVVESGDPCTLLSTEGSYFSRLYASSMALAEEQ
The following text describes a protein:
Function:
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
Subcellular Localization:
Nucleus.
Sequence:
MEQRLYKLESRNMDSCLRRLKLELLSMKEAGDGLHAQMNSMMGALQELKLLQVQTALESLDISGRPINRGMPHPAPAAPSHTRAAASAEERSSSLRQTMMDEPSPSPMLRPRLSVDSPNSSSRGDEISSQSRSSLETSSSSTSSLESESESEASPRSARNSRSENDLESIPRRWSGYTAPQVDFCGPVVGNPPPEPYLHSKTPRAAQVMDLPGILYSLSREGPSLDSDYSQDSADDGSDWTSSLMSRSRNRQPLVLGDNVFADLVGNWLDLPEVEREEGKNKEWRKRRDERTLEGSVDRPDTPAHPLRLSRSQEICKKFSLTTNIFKKFLRSVRPDRDKLLKERPGWVAPELQEGDIFKRPKKVAPKNSKGSFYLPFWANGQQGKGRPCPERSSHLQLFPQFQQQPFTGIYLDRRQPDTGLEKMQPLFDYNTAVWV
The following text describes a protein:
Function:
Has bactericidal activity.
Subcellular Localization:
Secreted. Cytoplasmic granule.
Sequence:
MKLFSCLMALLLFLLQAVPGLGLPRDTSRCVGYHGYCIRSKVCPKPFAAFGTCSWRQKTCCVDTTSDFHTCQDKGGHCVSPKIRCLEEQLGLCPLKRWTCCKEI
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MSSSVDNLLRHIHWGKIAVEETFDVYHGGSKLKSSFRDLNTKENIVESPALNHSKHFAFYLPQCQGPLGRGNSRQEPCGEPHPTFQVELHVSYCPEVGGLESYCRPAKDCAVWYNIVRTIPGTSCTLETGQGGQGICCPNMRYNGSMQRLVCRHGATFSKPSSCHQGLQPDPHPDRITEITVKEAVELGELQISPRITPKLSGCLDELQMVDNFPSHIYSFTLIDVDFHDYIICLICLVPVLVHPISFFTTYLSRYFVS
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MIINMASFNKHYHELKVVFIFALLCYPHVTVITDGGNVSNWPGKETRGMKVGSRPPRCEGKCSNCRPCVATLIAPGHQVKKVTISSSKEDGTYYLLAWRCKCANKLFQP
The following text describes a protein:
Function:
Required for associative learning and memory in adults. Expression pattern suggests a modulatory role in memory formation. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve.
Subcellular Localization:
Secreted.
Sequence:
MRSFCCCFYPAAVALHCVLLFYTFFLLFRASALRRRVVSGSKGSAALALCRQFEQLSASRRERAEECRTTQLRYHYHRNGAQSRSLCAAVLCCKRSYIPRPNFSCFSLVFPVGQRFAAARTRFGPTLVASWPLCNDSETKVLTKWPSCSLIGRRSVPRGQPKFSRENPRALSPSLLGEMR
The following text describes a protein:
Function:
Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal).
Sequence:
MDIVTPILTPFTKEGKIDVEKLKAHAKFLIDNGIDLLFVNGTTGLGPALSKEEKLTTLKTIYDVTNKVIFQVGSLNINDVIDLVKASKDFDIVGIASYPPFYFPRLPEKFLLKYFTTIANYSPHSLYIYNYPLATGYDISAKIVYQMKDLITGLKDTNQDLSHSLEYKILMPNLKVYNGSDSLVFYSLTSLDGSVTAASNYLPHVMKKMKEHITSGQVSKAIELQKLINKALDISRKYGQLSAIYYLVKEFLGYDVGYPRGPIFPLEEDEVKALLSEIQPVKKEIERAVS
The following text describes a protein:
Function:
Is involved in the biosynthesis of trehalose but not in that of capsular glucan and glycogen.
Subcellular Localization:
Cytoplasm.
Sequence:
MPEFRVWAPKPALVRLDVNGAVHAMTRSADGWWHTTVAAPADARYGYLLDDDPTVLPDPRSARQPDGVHARSQRWEPPGQFGAARTDTGWPGRSVEGAVIYELHIGTFTTAGTFDAAIEKLDYLVDLGIDFVELMPVNSFAGTRGWGYDGVLWYSVHEPYGGPDGLVRFIDACHARRLGVLIDAVFNHLGPSGNYLPRFGPYLSSASNPWGDGINIAGADSDEVRHYIIDCALRWMRDFHADGLRLDAVHALVDTTAVHVLEELANATRWLSGQLGRPLSLIAETDRNDPRLITRPSHGGYGITAQWNDDIHHAIHTAVSGERQGYYADFGSLATLAYTLRNGYFHAGTYSSFRRRRHGRALDTSAIPATRLLAYTCTHDQVGNRALGDRPSQYLTGGQLAIKAALTLGSPYTAMLFMGEEWGASSPFQFFCSHPEPELAHSTVAGRKEEFAEHGWAADDIPDPQDPQTFQRCKLNWAEAGSGEHARLHRFYRDLIALRHNEADLADPWLDHLMVDYDEQQRWVVMRRGQLMIACNLGAEPTCVPVSGELVLAWESPIIGDNSTELAAYSLAILRAAEPA
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Sequence:
MEGVLLSVREIEEYFFCPLLFYYKNYLGIDTQEGFWAYLGKRAQEEAEEEIRKRFEILGKEVELRSDRLGVVGKVDFIVGRGREIMPLEVKFSGRLRPWWKYSISLYAMLLEDSIGRPVKSGVVLVTRGMRFIEVRVGDSERRFVLGAIEKCRRIMEGEIPRAYRSRSCENCDFKNRCLEI
The following text describes a protein:
Function:
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). Phosphorylates CEP131 and PCM1 which is essential for proper organization and integrity of centriolar satellites (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrioles throughout the cell cycle. Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity).
Domain:
Cryptic POLO box 1 (CPB1) and Cryptic POLO box 2 (CPB2) domains can simultaneously bind to both TENT5C and CEP192.
Sequence:
MATCIGEKIEDFRVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRRKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLAAQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSKKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDRRRLLIEQPLPNKMTIFPKNKNPSDFSSSGDGISFYTSWGNQEQETSNSGRGRVIQEAEERPHSRYLRRAHSSDRSETSHGQSRVKTYTMERCYSAEMLSKSKRSGVEENERYSPTNNDANIFHFFKEKTSNSSGSFEGPDNNQALSNHLCPGKTPFPFPEQTPQTEMVQQWFGNLQINDPSCEQSKTRGVEPPLVYQKRTLRSITSPLTAYRLKPIRQKTKKAVVSILDSEEVCVELLKDYASQEYVKEVLQISSDGSMITIYYPNDGRGFLLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCVLMENSPGADFEVWFYDGAKIHKTEDLIQVIEKTGRSYTLKGESEVNSLKEEVKMYMNHANEGHRICLALESIISEEEKKSGSAPFFPIIVGRRPSSTSSPKALTPPPPVDPNYPMRETPSLNRMIINSAASPKQAPVLNPPVVTNEGLGLMGAASETNSSPRSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPSFH
The following text describes a protein:
Function:
Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes. Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin. As a heterodimer with Chrac-14, binds DNA and facilitates nucleosome sliding by Acf. As part of the CHRAC complex, required for oogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MGEPRSQPPVERPPTAETFLPLSRVRTIMKSSMDTGLITNEVLFLMTKCTELFVRHLAGAAYTEEFGQRPGEALKYEHLSQVVNKNKNLEFLLQIVPQKIRVHQFQEMLRLNRSAGSDDDDDDDDDDDEEESESESESDE