lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein; Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
Sequence:
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKCDFEFKAKHRIAHKPHSKPKTSDIFEADIANDVKSKDLLADKELWARLEELERQEELLGELDSKPDTVIANGEDTTSSEEEKEDRNTNVNAMHQVTDSHTPCHKDVASSEPFSGQVNSQLNCSVNGSSSYHSDDDDDDDDDDDDDNIDDDDGDNDHEALGVGDNSIPTIYFSHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKNSTGSGHSAQELPTIRTPADIYRAFVDVVNGEYVPRKSILKSRSRENSVCSDTSESSAAEFDDRRGVLRSISCEEATCSDTSESILEEEPQENQKKLLPLSVTPEAFSGTVIEKEFVSPSLTPPPAIAHPALPTIPERKEVLLEASEETGKRVSKFKAARLQQKD
The following text describes a protein:
Function:
Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus.
Miscellaneous:
MISCELLANEOUS: MINAS-60 is the product of an alternative open reading frame (alt-ORF) of transcripts coding for the RBM10 (AC P98175) protein. MINAS-60 and RBM10 ORFs are overlapping and are formed by shifting the reading frame.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKDVVVVVTGLAAMEPLTARRMMVGRTAAETTTTGTWTTVHILASMAARRASMTMTTHLRSRVRRIPTRPPRAPRLSVGGGGGTGTAPPARQASPETATIGTRTIGPSKGRRRRRRRMRRRRRRPVTSSC
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MEMASAAGGVPKKLDDDPAAHAAEPWPPAAREEKNKLWRRVLLVGSLVTLPLVAFFVLGRESASTAWLQMAIAKLTAMNNGTAGFTEGPHVHGRDELLGGLLAPGMDRRACRSRYQSWQYYKHFPFAPSPHLLAKLRAYEARHRRCAPGTPLYAKSVEQLRSGRSADDMECAYIVWLPFDGLGNRMLSMVSGFLYALLTDRVLLAAVPPDSADLFCEPFPGATWRLPAEDFPVANLFGVGQDIDRSYTRLVGDGKVGPGLAAANATPSYVYLSLGWQLKDPLFFCGEHQRALGKINWLLLYSDLYFTPSMYAVAEFQDELRRLFPERESVHHLLSRYLLHPANPVWSLVTRYYRSYLPAATRRIGVQIRMFGHSSIPADDMYNQILNCSRQEHILPETEDGDEDAIDRNGGDGSNNSTAILVVSLYADHFERLRSRYYEHAAKGGEMVGVFQPTHGERQATDNLAHNQRALSEIYLLSFSEELITSGLSTFGYVSSGLAGVRPAILLTAFDHKVPETPCRRVVSMEPCNLTPPRGLECTDKPADVEDLARHVRVCEDFNDGVKFFD
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Sequence:
MAATPSAPAKSEMIDLTKLSPEQLIQIKQEFEQEITNVQDSLSTLHGCQAKYAGSKEALGTFQPNWENRQILVPLTSSMYVPGRVKDLNRFVIDIGTGYYIEKDLEGSKDYFKRRVEYVQEQIEKIEKIHLQKTRFYNSVMSVLEMKQAAAAKLQSQQQSQPAVTQSS
The following text describes a protein:
Function:
Involved in chitin biosynthesis.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MLVSNGGTGSAHEWDRTTIDYDIEPSSDTHAIEISSNDDYLHPLAQFKKSEEFDEVPTNTLIHEVPSFSDSASNIQSQRNLSPFKELEIVSKKKSEQTFSSAVDFSAINVKNLNLKSGLFDPEPPSYDPDYAFNQRSLQSDPGSDEMFRNFKKSISLEELKSSYKLASAEMCEPETRLSFLQLALQAEKSSSRRNREYVARKKEEAFDYLTSFVSQGNSFFGYSEALYLLAVCYGTGALRTEINEKEAYRLYKMAADLNHVQAAYRVAICLQMGFGVTQNTEEAIHYFFRAASGQHVGAMHRMALIYFRGLMSVKRDPVKAMYYLNLGALEADHEFPQALYDLAELYEHGSSYLDGLLELSPRKAFVLYHIAAKYGLKDAQLRVARCFELGQLECDINLVRSFVWYRRLARKRNPEAMWKLSQFYLNGVDDVIYPNPELANEWAKAAAYKNHHLASTFVQDVGKEDVFEKTSITISNEERKSRNSESLPKKKKRLSMLSFKRSKNRESCIIS
The following text describes a protein:
Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Sequence:
MREVRIVVCGDQGVGKSSLIAALVQEDNVTSIPKVFPVISIPSDPIVNDDVSLVIVDTQSDAAERELLETAIKKAHTICLVYSDNYTYERISIFWLPYFRSLGVNVPVVLCANKSEDIDNNQGLQLINHEMVPLMNEYKEIEACIRCSAAERINVNELFYVCRSCVVTPITPLWETKEHRIKCAARDALSRIFFLLDKNNDSLVGVDELNELQNLCCSKMFTPDESKDIFDCVRAICPEGILGDSLNINGFLAYVSHMIENGKQESIWGILRAFHYTDSLSLDEGYLYPLLDVSSGQSVELSPKGYRFLVDLFYRFDRDNDGALNTKELAALFRFTPGLPETWIQSQFPNSTALNEHGCVTYNGWLAQWTMMTLFDYKTTLAYFAYLGFDSGTRQSVLEAIKVTKSRSLRNRRQIKVDRNVFLCLVVGQRGCGKTSLLSSFINSDYRGSLTPPPSTVVNSVEFQSKQRYLVLSEVQDTDYDVFSDVRTLDACDVLCLLYDSSNPSSFSYIANILESYPLLNKIPCVIAATKADLDRQQQRYTIQPDEYAKRRGLSSPTHISTAAAWNAPKEFFIQLAEAAQHPASAMPNSTETEENNNRFRMITALTAFGTLVLTVSGSLIWRIMKQRGSSSNR
The following text describes a protein:
Function:
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDTPYRKMLAAKIHRATVTGADVNYEGSLTVPPELLVAAKIHPYESLHVWNVTRGTRLETYAIEGLPNSNDVCANGAAAHLIRPGDHVILAAYAMVPEADAATHKPRLIFVDDNNQLSHVGPEIAGPNLRSDSDDTHLVRSTEMTPDGQPLAEGC
The following text describes a protein:
Function:
Required to negatively regulate vulval development. Antagonizes Ras-mediated vulval induction. Acts cell autonomously.
Subcellular Localization:
Nucleus.
Sequence:
MSEELLSTRPSKRDYNDIEEPEDSHVTVHSVEQDSQHSGEESSTVDALQETEGDVDVIGEDEDEHDIPVMPTVTSSGEVLDESQVTPTKQASSSQPREEIIHGKGESVYSSFPCQVIPETLSRMTRTPPDGEHLEVYRMSNGRLRIYVVDHFKKFSPYSNLTHKPCTVCNRVMKSGEMHLNFPADLDRRRIWANLLGFKYKDILRSKMGPVSFSIAAGPICTEHFAEECFRNHNFNKSAIEAFGVPVAISPDVKTTPSKKSSRVPWVCTVCEFHSCSVVELQTHLLNHTEEMLKKKDNVLDVPEAGFMCPFCRKCTYGYKTISGYRRHLNAGPIHHCHLRRIYEFAKMNCRATELDPAESWDNWTRRNVYVAYHGCEPPANEIVLTPSPTKKAYVQNPEERTKMVHDEEKRKKAVRTLSFVGKEGGTSVNDLNVMQRQVFLQLRREAEINTKAEESAQGTKEQESSQKKHAEEESDDVSELTSHQSPQAPMGSGERRKATRLATSATNSPIKKVAKHEVPATAPSTPAKKRKISHEEEHDPTPESVEREPTVSPNDPRERLRLKERDEQFAKMVQKRSQQVKRLINAKQFKKQEAATKKPRKALAYNLAKGIAATSSTEPEDKVTSSEQTPEPTTSQKFIARNTRSKTKESAVQKVEKPATPVAKPAPVEKEPEERPLKSMLARSFVAGVRPSMAKYQIPLESFTATASLGGGRSLSSGVISRPPTSSSPGGIFSQRVMGAVAQEKGPAKRPSVLSRRPLILSPRKKTSTPRPTLSHHESSPNFSASSPVVVSDEYLIPATDMEVEMVEEVIDSMGNSSSEDVATSSTSSERQPMLTLAEALEMDGSSGTVKDQDMEEISKEMMKDAHYYRAMEDAIKCRTVTKMRADMRLSRHCIRQIEAARARARLFGERTEDYQIFYSNDGAQVLTKKDPKWRELQQQQQQQQQQQEQFPGQGSSDSQQ
The following text describes a protein:
Function:
Involved in pH regulation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.
Sequence:
MSSYFWAQNESNRPDLLCGQPADYLVEEKHFTTLVCFIVVLGGLLKMCLKNCEVIVLTILSLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLIIFMVALDVEFYTLKKMFWQVLLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITLGIIDPLRSVNSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRGNRIHFSIFRDLHVGIELSYDILGSIIFGYWCAKIIQCILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPILMHSNYEYNWRWGVVITWSGIKGVFNLLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNATQHIQEIVQNTITLFKTEKILTNVNWTLVEDKTRIEYIPFSHVSHNDMKTESTTDEALMEEARLHVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIKKRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLTFLCSRGIIDKHEVIEINKVLLKKLKALNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAILHSLSPTFGIESNQRCDRGSRDMFTEFCTTGDIIGELSCLLKREIEYTVICETSLQACFISLEDLYEGFDAFWPSLEYKIWLKLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVETLSSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLIIQASELTQRNSNTNVMASVNTVFEQPGKNINGRQKMS
The following text describes a protein:
Function:
Isoform Holin: Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Determines the precise timing of host cell lysis (By similarity). Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell (By similarity); Isoform Antiholin: Counteracts the aggregation of the holin molecules and thus of pore formation.
Subcellular Localization:
Host cell inner membrane; Multi-pass membrane protein. Note=Classified as a class I holin.
Sequence:
MMENDEWWKYLIFPLVATLGGIVNYSKRALAMKRFSKLEFAVEAVSAAFVGLMVTLGGAAMDLSPHWLGMAAGMSGWMGADFVKAVFSQFVQSKIAPINQPGPIDSDNDKPGRTFND
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Sequence:
MFSAVKPLSKYLQFKSIRIYDSVFTIHSRCTVVILLTCSLLLSARQYFGDPIQCISEEKNIEYIQSYCWTMGTYILKLDDFGDQEQALVSPNQEVSYNSAFFSSATTNAPQSSSRVRTRPHFRSSLRRIGEYNEAYARSLSIAEGVGPEIRGQTERQYLRYYQWVIILLLFQSFVFYFPSCLWKVWEGRRLKQLCSEVGDALLSEETYNTRLRMLVKYFTTDYEDMHFCYMAKYVFCEVLNFLISVVNIIVLEVFLNGFWSKYLRALATIPFYDWDRWNRVSSSVFPKIAKCEVLKFGGSGTANVMDNLCILPLNILNEKIFVFLWAWFLLMALMSGLNLLCRLAMICSRYLREQMIRSQLRFMTKRHVKRALRDLTIGDWFLMMKVSVNVNPMLFRDLMQELCELRTSASGSTLESPV
The following text describes a protein:
Function:
Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Co-localizes with the tectonic-like complex.
Sequence:
MKEVLPLVVLCLATYHTHSIKIGISHNYNATISPTASTTTEAPATTGAPSSETVSSISTLPEAEVTTTTPAITFPPRVQQKPKVAVASPTMSTALPLNSTEVNSTLSVSGDNTFYYCSCDLQAGRCDLNCCCDNDCPLETRQVFNCLPNSLLPQLESRLEDFQYTHGLPTCQINDGWLCVFRSNTKATKTQPPDMNIDTSQYRKWKDNLEYQESDYAQSRPSAGHYKFGQTLQLWQPETKQLATLELPAAYESPNCQLKQSVWHLQPIRHVCRMKDSAQLQESIWSLLNQTSNYEILSKPRDLEEPEVNGLIVQVCLRGANKSMRCLERGNDTQLDVIVDHVELQLIHNFTNILEAKLFLEEAKLAEDDNEPLWLRYNVEFVTLNESLTKPTSGPLGYLSGAPVILSRMLPQNSSEDKQLISYHSLNQNIKEFHWLSLPSRKPRGSSCQRALDHKEALRFGIDLLTRCELRHAAPLLQAHANHTEYCQGLQAQIWSLLLPHNCTQLEDVTKVFVSHLGRPQPDKWLPMEVRYPENVHEMPPPVQAVYDEMRQSLSCRNIFLSVGYEFHVAHLAMVEGRAPHQRVLQHARLVLGQRHDLEFDTSEIEVALPLSISAMFYRMQTKALSNGAAVGIAGHLVLVEMIYLGIIYLGSMQLCL
The following text describes a protein:
Function:
May have a photoreceptor function. Binds DNA; probably functions as a transcriptional repressor (By similarity). Has no photolyase activity. Upon purification from either V.cholerae or E.coli an approximately 60 nucleotide RNA is associated with the protein.
Sequence:
MSKKIGLYWFTNDLRVNDNPLLEQASQQVDRLICLYCYPSITPFLARYAQQTQWGEAKKRFLNQTLADLDHSLSTLGQKLWVTPLLPYQALRHLLTQVEITDIYVDAVAGSDERQAIARIHQDFSSVHIHQQALHSLLSEPQLPFALEALPSTFTQFRKQVETISLSAPMGYPHVLPPIEQGWQLPLMDIVTEPNHSAFVGGEQAGLTHCQNYFSSLLPSRYKETRNGLDGMDYSTKFSPWLALGAVSPKTIYAMLQRYEAVHGANDSTYWIFFELLWREYFYWYARRYGAKLFRFSGIGEKKPLTSFYAQRFLQWKHGETPFPIVNACMRQLNQTGYMSNRGRQLVASCLVHELGLDWRYGAAYFETQLVDYDVGSNWGNWQYLAGVGADPRGSRQFNLEKQAHTYDPKGEFVAKWCGTACDKLNALENLALDSVDMVDWPIAASAYLLIHHPQNKESSS
The following text describes a protein:
Function:
Stimulates catalytic function of the p21-activated kinase homolog shk1.
Sequence:
MAEETEEDYLVVGRDYLYPPDHELHYGFHARVIEEEEERFVDDTFDETIEGSDDSESIDDTEVFYDAEESESTHPSASFNVLADAVALYDFEPLHDNELGFTTGQRLCILSESSDGWLIAYDDASGRSGLVPETFVKLEV
The following text describes a protein:
Function:
As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.
Subcellular Localization:
Nucleus.
Sequence:
MATPDAGLPGAEGVEPAPWAQLEAPARLLLQALQAGPEGARRGLGVLRALGSRGWEPFDWGRLLEALCREEPVVQGPDGRLELKPLLLRLPRICQRNLMSLLMAVRPSLPESGLLSVLQIAQQDLAPDPDAWLRALGELLRRDLGVGTSMEGASPLSERCQRQLQSLCRGLGLGGRRLKSPQAPDPEEEENRDSQQPGKRRKDSEEEAASPEGKRVPKRLRCWEEEEDHEKERPEHKSLESLADGGSASPIKDQPVMAVKTGEDGSNLDDAKGLAESLELPKAIQDQLPRLQQLLKTLEEGLEGLEDAPPVELQLLHECSPSQMDLLCAQLQLPQLSDLGLLRLCTWLLALSPDLSLSNATVLTRSLFLGRILSLTSSASRLLTTALTSFCAKYTYPVCSALLDPVLQAPGTGPAQTELLCCLVKMESLEPDAQVLMLGQILELPWKEETFLVLQSLLERQVEMTPEKFSVLMEKLCKKGLAATTSMAYAKLMLTVMTKYQANITETQRLGLAMALEPNTTFLRKSLKAALKHLGP
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Forms part of the polypeptide exit tunnel.
Sequence:
MKAQKYSKEGKLISEIELPSALFESKLSVASIYEAIKAENANLRSGNHATKTRSMVSGGGKKPWSQKGTGRARQGSTRAPHWVGGGTVHGPQKRDYSYKVSSKLKHRAVLSILGKKAQASAVKVVEDLDPKEYNTKAFDSIFKNMNLKNTGVIGLLVQGENDFLKKSVRNIPTVKYINSKRISCRDILYNRNLVITEAALKEMLVQYGAQK
The following text describes a protein:
Function:
Outer capsid protein involved in mRNA capping. Catalyzes the last 3 enzymatic activities for formation of the 5' cap structure on the viral plus-strand transcripts, namely the RNA guanylyltransferase, RNA-7N- and RNA-2'O-methyltransferase activities.
Subcellular Localization:
Virion.
Sequence:
MANVWGVRLADSLSSPTIETRTRQYTLHDLCSDLDANPGREPWKPLRNQRTNNIVAVQLFRPLQGLVLDTQLYGFPGAFDDWERFMREKLRVLKYEVLRIYPISNYSNEHVNVFVANALVGAFLSNQAFYDLLPLLIINDTMIGDLLGTGASLSQFFQSHGDVLEVAAGRKYLQMENYSNDDDDPPLFAKDLSDYAKAFYSDTYEVLDRFFWTHDSSAGVLVHYDKPTNGHHYLLGTLTQMVSAPPYIINATDAMLLESCLEQFSANVRARPAQPVTRLDQCYHLRWGAQYVGEDSLTYRLGVLSLLATNGYQLARPIPRQLTNRWLSSFVSQIMSDGVNETPLWPQERYVQIAYDSPSVVDGATQYGYVRKNQLRLGMRISALQSLSDTPSPVQWLPQYTIDQAAMDEGDLMVSRLTQLPLRPDYGNIWVGDALSYYVDYNRSHRVVLSSELPQLPDTYFDGDEQYGRSLFSLARKIGDRSLVKDTAVLKHAYQAIDPNTGKEYLRSRQSVAYFGASAGHSGADQPLVIEPWIQGKISGVPPPSSVRQFGYDVARGAIVDLARPFPSGDYQFVYSDVDQVVDGHDDLSISSGLVESLLSSCMHATAPGGSFVVKINFPTRPVWHYIEQKILPNITSYMLIKPFVTNNVELFFVAFGVHQHSSLTWTSGVYFFLVDHFYRYETLSTISRQLPSFGYVDDGSSVTGIETISIENPGFSNMTQAARIGISGLCANVGNARKSIAIYESHGARVLTITSRRSPASARRKSRLRYLPLIDPRSLEVQARTILPADPVLFENVSGASPHVCLTMMYNFEVSSAVYDGDVVLDLGTGPEAKILELIPATSPVTCVDIRPTAQPSGCWNVRTTFLELDYLSDGWITGVRGDIVTCMLSLGAAAAGKSMTFDAAFQQLIKVLSKSTANVVLVQVNCPTDVVRSIKGYLEIDSTNKRYRFPKFGRDEPYSDMDALEKICRTAWPNCSITWVPLSYDLRWTRLALLESTTLSSASIRIAELMYKYMPIMRIDIHGLPMEKRGNFIVGQNCSLVIPGFNAQDVFNCYFNSALAFSTEDVNAAMIPQVSAQFDATKGEWTLDMVFSDAGIYTMQALVGSNANPVSLGSFVVDSPDVDITDAWPAQLDFTIAGTDVDITVNPYYRLMTFVRIDGQWQIANPDKFQFFSSASGTLVMNVKLDIADKYLLYYIRDVQSRDVGFYIQHPLQLLNTITLPTNEDLFLSAPDMREWAVKESGNTICILNSQGFVLPQDWDVLTDTISWSPSIPTYIVPPGDYTLTPL
The following text describes a protein:
Function:
Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells. At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole (By similarity). Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure (By similarity).
Sequence:
MEDFDLVENLQKTSPSVESDIKSAPQSLGLSLHANRSSPHLSTNGVSSFSGKTGPPVIQGTVEVLTALRQDLQNSGRTDSELWKSCERIQEEIRKLVKLQLSHASRPSCSSSSVSEQVSAETQMGFFSENSERNESVVSSPASKEPETQPASSTSYPDCHVDSSSVSSGYGTFCILDMNTHKAKEPTEPLEPGAASQGQHPASVVQAHGPAGGAAAINFFTQTPEELCASLKEDGSTFPGEFDRNFLGENKISEVYSGKANSGKSVTSWAQRLKQNQSKQAHTEDDCSGPKPGSELNWKPPADTFDLAADAARPCAFYINKPAESPSSWLSDSGTGLTYWKLEEKDMYHSLPETLEKTFAPSPAERPLSQVLTLDPGAIRMKPKEHVAGIQAHGFLHALDDRISFSPDSVLEPSLSRHSDTDSSSQASHNPSQVSGFSKYPSTTRASPVDTWKNHAFQRESRTSSTIPSRYTITSNDISVKTVDEENTVTVASVSQSQLPGTANSVPECISLASLEDPVMLSKIRQNLKEKHARHVADLRAYYESEISSLKQKLEAKDISAVEEWKKKNEILADRCGQLDSALNEATSRVRTLEKNNNLLEIEVSDLRERFNAASSASKVLQERIEEMRTSNKEKDNTITRLKCRLQDLEEAFENAYKLSDDKEARLRQENKMFQDLLGEYESLGKEHGRVKDTLNTTENKLLDAHTQISDLKRTISKLEAQVKQAEHESMLSLRNGAKVPERPSRSNSVATSDVSRRKWLIPGAEYSIFTGQPLDPRDRKLDKQLEEALVPGYHSPPEKDSSLGSSPASLLVKKKRDTPDTPPIIKALKELDEERVFKSWGTQTEKEDSSSKLVNSRQTEPSVNTGRSPEKCAQQRPKRQTSASQRSSSLPPSSRKANTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPVRFDILLDDLDTVPVSTLQQTTAKKQLQFLLDDSEEKKYSEKNSDDPVNPSSCPEHSPNGLKKVSTRQAWEKSKSVSLEQCQPGSAAPQDNGFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLEKINRELGSVRMTLKKFHVLRSSANL
The following text describes a protein:
Function:
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (By similarity). Involved in DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation.
Subcellular Localization:
Nucleus. Note=Accumulates at sites of DNA damage.
Sequence:
MSQKRNLPSWMSSRDPEITPSKSHCKKPKDEGPTEEHNSRNAPSNKSEHAEPSSNTTEFSKLMEGVVFVLSGFVNPERSTLRSQALTMGATYQPDWNAGSTLLICAFPNTPKFRQVETNGGTIISKEWITECYAQKKLVDIEQYLMHAGKPWRKSSSPQDANREKREHLSKKPEKQVEKKTETRGTPSTSSKNRSACNLVKEPFFVTEVKKWARDDLSQTISWLESQEEKPEPGEIKRIAAEGVLTCLQDAIDSLEQKQDIGSVTELWSFVPRVVKELGKMESSSKKENSTASKEEVCKQAKSWKKIYEAELAKPGEDESTSRVACGYDSDMTVEMTEEEIELAYRNVSLECL
The following text describes a protein:
Function:
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle. Lysosome lumen. Lysosome membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MKPSDFIGGILVIISLCFFPSCDTLSPVITHKQELWVSQKQGEVHTYRTPILVKLPTGDLLAFSAPRKNTSADKSAKFITLRRSTDGGLHWDVTRIIEDDYDVEDGLNLGSVIIDKITNTTYVFFGYCQHTPGTCTSPYREKGVYFKISRDWGYTWTPAINVKETNSALEGITWAPGPGFGIQKELEPNKGRLIGCGHHVDVAFYQMQCIYSDDHGKTWHMNSPLYGLPYAQKHITGDFTPGETQVIELSNGTVFVTIRNENKFHCHCRLQSLSYDGGYSFLIPHLTVQEALVDPSVFGSLALLNNTLFLSHPYNTDSRINMTLQWSFDSGQTWPGAMQLYEGPSEYSSLAQIDDEYLGLLFERDGYKYIDFFKIRIK
The following text describes a protein:
Function:
Component of the NF-Y/HAP transcription factor complex. The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters. May act through association with MADS-box proteins. May regulate the expression of genes involved in flowering.
Miscellaneous:
MISCELLANEOUS: Probably not a component of a NF-Y/HAP transcription factor complex. Shows impaired association with NF-YA/HAP2 and CAAT motif binding.
Subcellular Localization:
Nucleus.
Sequence:
MAGNKKRGGRNMDQVKKAAVRSDGVGGSATNAELPMANLVRLIKKVLPGKAKIGGAAKGLTHDCAVEFVGFVGDEASEKAKAEHRRTVAPEDYLGSFGDLGFDRYVDPMDAYIHGYREFERAGGNRRVAPPPPAAATPLTPGGPTFTDAELQFLRSVIPSRSDDEYSGSSPAIGGYGYGYGYGKNM
The following text describes a protein:
Function:
Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form.
Subcellular Localization:
Nucleus envelope.
Sequence:
MSRRSDLSDKDSQSRKRHWLTDQAVTNEEKEQSPTKRTRKTKSQGLGGLFNTFFGMFVSSNSGEKEKTEVSGEVQVQEDDEIIVEGTTRRVAENKKYMIFLNEDAPVRANAGSEENEVIIEKHVQKNVEIRNDEEKQEVQGDLVLTLSSSPKSPKNLEKSFEVQQDDEEPDVLFEKVVKTPNKQLQEARRFQNELIFLNDNPDTPDDVSVISDSRSKEFISPTPDDSVSRPITPSLSSLSNYTSNNVRDYWRRNSAKKPEVLRRVPVRHQFKHSTSVRKMNTIIDLKKIKNHLSSRDRLLQGVVASGQYEAKAISGIVEKKPKKMQRTSSTDILARAKNKIAELGGSRSNTPSLLSREPSIIIDSEESTSSSYRQHARSNSSESDSYRKLNDILSQINSLGIGSAYRGPQRYQNSYQLSKQKEDKLLEEARIREGHRSQTRGDRLEDVRKRLELQGIAIRPKVEKKKVDDFMALPDAADALVERAWSGGNPNEQFVDAFSIQICKKDLATLSGLHWLNDEIINFYLQLICDRSNGDSKYPKIYAFNTFFYSNIVSKGYASVKRWTRKVDIFAFDIVLVPVHLGMHWCMAVIDMGEKKIEFYDSLYDGNTAVLPALRGYLEAESLDKKKTAMNFSGWTIQQMTDIPRQQNGSDCGVFSCQFGEWASRRTTPRFTQKNMPYYRKRMVYEIVSKKLLATI
The following text describes a protein:
Function:
May function as a flavin mononucleotide (FMN)-dependent alkene reductase on substrates carrying alpha,beta-unsaturated carbonyl groups (ketones, aldehydes, carboxylic acids, esters, lactones or cyclic imides). The catalysis depends on NAD(P)H, which acts as a hydride donor for the reduction. Seems to be involved in metabolic pathways required for efficient replication of amastigotes within macrophages; Acts as a FMN-dependent nitroreductase that activates anti-leishmanial bicyclic nitroaromatic prodrugs including delamanid, DNDI-VL-2098 and (R)-PA-824, forming toxic products that kill the parasites.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSAASKSIDVMLKPLLVGGRPISNRFVMAPLTRCRADDNHVPTAAMVKHYSDRASMGLIITEATQIQKGYSTFAHEGGIYDKEHVDGWRKVTDAVHDKGGIIFCQIHNGGRSTVPSNVDEGVRIVAPSAVAITGHKCAGSFARNGKTQPYPVPHAMAAEEIASYVNLYAAAARNAIAAGFDGVEVHGANGYLIDQFLKTSSNQRTDEYGGSIENRCRFLFEVLDAVIQAIGRERVGLRISPLNSFNDQSDEDPQALTRYICSQLNLRTIAFLDVMRGDFFSPARGADKWAREEYEGVLFTGMSFEIEEAAKAVESGAADAVVFGTKALANPDLVARAVAGAPLNKPDPATFYTTGEAGYNDYPFM
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPVNRYQIRNEYSLADPELYKAADKDDPEALLEGVAMAGLVGVLRQLGDLAEFASEIFHDLHEEVMATAARGHSLTVRVKQLEADFPLIESAFLSQTDHSSFFYNAGTDWHPNLRIDQNMVTRGDLPRFVMDSYEECRGPPRLFLLDKFDVAGAGACLKRYTDPSSFKVETSSYAFTTSDVQREKKTRKTKKRGSRWRNGETPEVLPTSHAKLHQLFLEERIENGINVPAHRVKLKRKLNGFPFDPRTGKSYMNKFLEISSPEHKVVHEVGIDSSPLRLPSTDACETLAETEDIRPPSPDKEVMRRNKRASLSPSPPQSAENNSLRPCLDEVNGDLSCYRVRGISRRSHRSQTTDILPSIHSLVDEKEITVDGESRTEKGIGYESDDVASEIDNYVDALTTMEAELETDSEQRDRRDLPFLNSKKQVLCLSSSSEKLQTQSSDSHSIENSTLSDDGNSYSKKEISSFSCSDSPSTSVESVLLESEISSKGAKTSDTSCEQQSVNEETQLPQPPEGGVYDRKCIIVAREPSGSCDSGEKTATLNFTDSSPMPIHAYTEIFVEVAGMRAETNENFITHGKSEDPLTTIAEDASSLHVSLPHAPVILDAPEQNGDDSPSRASIDIKLTDGLVDQNLKLDENVSCASSHSDVPYHATDNMPESESPVIQHESNLYNDASLVNNLPITSELLNIPSEDRHEVLSADYQQLPNLDGEDPSVGDDSASLYNLPNCPSSEEGHTSPSLLAVNHPNHVDNGLDNENLNGSSVGSVQILDVLGASDTDCGKHFTMSHDEIAEDACMKPHNISTKDIEAGDADKDHEDTCGAFSDGVMSEPGDLSTNCGGDGLDFVDVLNSQTSEIPNDIQSLESGELNISCSRQENPVEVSSLTKIDEKGSIAPSELLSGTVSTGSIASRHLKSLTNKGILSDETVNKIDKSDVTDETASLLAALADKENFDDLSSSLDHKLFSEESVCSIGHSSQRELEIDLSNSHAESKFMTQRANTPDSNSFVLDTSNCHHPESAVLDTPSGSELSFDAENTMDSSAAPSQALLKKWCLDTEEVLSRRRNVADLTEDASSLQISPEEGKDELVDNQPNEELLHKVDLDQSPLLEKIQSHVDQVSDASSLSFVANLPSQDAIPDVLAHNSNLVSEPLLTDYCAEETAESAIHEQVKREVLDSGEAKAEPLPQLTQSQLVDCFDIEQSAEASSISSQTVRPSHPSFPELLSQSNQDSLSSLYKKDEEIASKVSDTERLIDEDTAKEVLLPQFEEARLSNHVDIVGALDASSVPFIANVPSQSPVSNPLSLSSHNVNPFEMGNTPTSPGFALLPDEAQTSLVEMPPLPPLPPIQWRMGKLQASPDLDGDPTQHYIGANPSSLASRTDQDPRPVNQNMLSAVATESSELIDLYSADSVAQSGLLTLPPTVLGGNSSIRFIDPVYKHYTKTHFPLAGQYHEVQLPSLHAIERGVAQPINWIPGVTSLDKPSIDVLGSSEELIQQQNQVAPELLLEKQGSAHLEGNLPLPVSDGIKPKALPADIVITDASESLFHEPSQPQHQPLHQLAPETCLDRSNLEETLTSLEKNVVTRGTVIPSYTENAKPDNSGPTTEAEIIWPAVEEGNTNEIRIVKLQRPRTPLIDDLAAHDKSKLRKVTERVRPETQKVDERDPVLQLRKVTERARPEIQKVDEKDSLLQLRKVTERAMPEIPKVDERDSLLEQIRKKSFNLKPTVATRPSIQGPQTNLRVAAILEKAKTIRQAFAGSDEEDDEDSWSDS