lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.
Sequence:
MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAEDTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLEGDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVLPESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENFTDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKNTNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEHGLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGEAMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAGVLIS
The following text describes a protein:
Function:
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
Subcellular Localization:
Cytoplasm, cytosol. Perikaryon. Presynapse. Note=Enriched at synaptic-releasing sites in mature neurons.
Sequence:
MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK
The following text describes a protein:
Function:
SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies. Is a component of complexes that can bind to U snRNA genes.
Subcellular Localization:
Nucleus, Cajal body.
Sequence:
MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDEYCPACREKGKLKALKTYRISFQESIFLCEDLQCIYPLGSKSLNNLISPDLEECHTPHKPQKRKSLESSYKDSLLLANSKKTRNYIAIDGGKVLNSKHNGEVYDETSSNLPDSSGQQNPIRTADSLERNEILEADTVDMATTKDPATVDVSGTGRPSPQNEGCTSKLEMPLESKCTSFPQALCVQWKNAYALCWLDCILSALVHSEELKNTVTGLCSKEESIFWRLLTKYNQANTLLYTSQLSGVKDGDCKKLTSEIFAEIETCLNEVRDEIFISLQPQLRCTLGDMESPVFAFPLLLKLETHIEKLFLYSFSWDFECSQCGHQYQNRHMKSLVTFTNVIPEWHPLNAAHFGPCNNCNSKSQIRKMVLEKVSPIFMLHFVEGLPQNDLQHYAFHFEGCLYQITSVIQYRANNHFITWILDADGSWLECDDLKGPCSERHKKFEVPASEIHIVIWERKISQVTDKEAACLPLKKTNDQHALSNEKPVSLTSCSVGDAASAETASVTHPKDISVAPRTLSQDTAVTHGDHLLSGPKGLVDNILPLTLEETIQKTASVSQLNSEAFLLENKPVAENTGILKTNTLLSQESLMASSVSAPCNEKLIQDQFVDISFPSQVVNTNMQSVQLNTEDTVNTKSVNNTDATGLIQGVKSVEIEKDAQLKQFLTPKTEQLKPERVTSQVSNLKKKETTADSQTTTSKSLQNQSLKENQKKPFVGSWVKGLISRGASFMPLCVSAHNRNTITDLQPSVKGVNNFGGFKTKGINQKASHVSKKARKSASKPPPISKPPAGPPSSNGTAAHPHAHAASEVLEKSGSTSCGAQLNHSSYGNGISSANHEDLVEGQIHKLRLKLRKKLKAEKKKLAALMSSPQSRTVRSENLEQVPQDGSPNDCESIEDLLNELPYPIDIASESACTTVPGVSLYSSQTHEEILAELLSPTPVSTELSENGEGDFRYLGMGDSHIPPPVPSEFNDVSQNTHLRQDHNYCSPTKKNPCEVQPDSLTNNACVRTLNLESPMKTDIFDEFFSSSALNALANDTLDLPHFDEYLFENY
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKNNLLSEKLIYTGDSLTPTHLHLCTYNATEMQESSGDTFQSVKETLDNERINWLQVHGLKDTETIREICSHFEIDFLVLQDILNADHPTKIEEHDKYIVLILKIFYPNEHKEDDDLDGLLQQQVCIILGNNYVLTFLEKETDFFDEINAALRNDILKIRSRLTDYLLSVLLNSIMANYISTISSIDDALEDLEEELLMITNENDIGIQIQGLRRQYMLMKKAILPLKEQYVKLLRAENLLIHKVNRAFYNDVNDHLQFVLQTIEICRETLSSLVDLYISNNDLRMNDIMKRLTIVSTIFIPLTFLVGVWGMNYKWMPELDWRYGYLFAWIIMAVIGIIVYLYFRKKKWY
The following text describes a protein:
Function:
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin.
Domain:
The C-terminal domain is required for high-affinity binding to chromatin.
Sequence:
MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MPQVKCSVKLEKEHAGSDASASQQQPNRRRISVRLKRPNPLFEMWLEEMIAKAEEKNTMGKMALQKALTSLRRYPLPLATGRDCIALMDFGKTICENLDRRLKAYLASGGRVVFDHTPAIEALLNDEQGEHYRELTRTVRQERVEEVMVVAEETEPIEEAMPNDSIFDHVPGAAAGGDEFVRITHPKAILLVDTCETIGKSKSGLDRTLQELTQYAVEHEVRRLSVGDFAWIVRNDSGREFLLPYVVERKRMDDLASSIKDGRFHEQKFRLMQCGLPNVIYLIEHLGNNRQVGVPEGTLTQAAINTYVQGFTVKYTENHHHTVLYLSVMTNFLNNSLQNKLYLDVTNRPATEPASEYRFSSQTVPLLSFEYFYKQSSKTRDTTVRDTFMKQLLQIKLLTIEKINAIVEKYPTPQSLFRAYERCPSETERQRLLNLPYGPTKRTIGDKLSKIIYQLMMSEGYTS
The following text describes a protein:
Function:
May modulate the level of one or more small signaling molecules that have a role in regulating meristem function. May play a role in balancing and restricting the meristem-promoting activity of auxin signaling. Involved in ethylene and giberellin (GA) signaling pathways or in a parallel pathway controlling cell and hypocotyl elongation and cellular organization. Involved in abscisic acid (ABA) signaling pathway. Plays a negative role in ABA-mediated seed germination and seedling development. Acts in association with LAMP1 to suppress ectopic stem cell niche formation in the shoot apical meristem (SAM) independently of cytokinin signaling pathway. Modulates responses to ABA, oxidative stress and abotic stress. Acts as a negative regulator of the ABA signaling pathway to modulate freezing and drought stress responses. Mediates carbon and amino acid metabolism. May be involved in the acquisition and/or maintenance of seed dormancy. Involved in the regulation of response to heat shock and plant defense.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MSQPLTTRPTVTGISIIPFRQPPPLCSFLFVIVLFVATFYTLHHPDAVTPPLLFSRNAYNALRLRRLFLSSASNATISSYLRELTRHPHLAGTKPSLDTLHYVFNHFQSLGLETHVAEYEALLSYPTHISVTASFSNTTTLEFDLNDVPGDSPVVRPYHAYSPSGSAQGNVVFVNHGEERDYHALESIGVSVKGCVVLARKGENLGRGAIVKIAEAKGALGVLIYAENDGGGFGGIERGTVMRGIGDPVSPGWPGVVGGEKLSLDDELVTRRFPKIPSLPLSLRNAEIILASLGGARAPLEWRNSGRVGPGQRVGPGRMVINMTFQGEMKMKKINNVVVTIRGSEEADRYVILGNHRDAWTYGAVDPNSGTSALLDISRRFALLLKSGWRPRRTILLCSWDAEEFGMIGSTEWIEENVLNLGASAVAYLNVDCAVQGSGFFAGATPQLDGLLVDVLKLVQDPDAVGLTVEETFKSQNNIIQRLSRVDSDFSGFLHHAGIPSIDMYYGADYPVYHTAFDSYDWMIHNADPLFHRHVAMAGIWGLLGILLADEPLIPFDYISYADQLQAHRDKLSKLLEGKVSVNPLSMAIQEFSLVAKEAADEAKKLKGKSYSKNDVAAAAKRRELNDRLMLVERGFLDAEGIKGKEWFKHLVYGPAAEPESKLGFFPGIADAIAMNASEGIIEHEIWRVARAIQRASKALKGGFT
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLNFSCSCISQHPSTATFLILSKRFNSSGYQAYRFSRTASLLCLGPVHPLRMFCILLITHPYFEIIVTLVILVNCIILGLNDPPEEAEYIFTAIYTLEMICKIISRGFVKDSYAYLRDTWNWLDSLVVFLSYLSLAPDIASLSGIRTLRVLRAFRTISALKGLRAMVNSLLRSLKLLTDVLVLFLFSLCVLALIGLQLFTGELRNKCVLETANATTINNPSSWYHREGEPLLCGFSSTAGRCPANYTCVAHVGPNPDHGFTNFDDIGWSLVMAFQILTMDFWENLYDRVLRSMGEWYMMYFVVGIFSCSFYLLNLVLAVVYMSYHHEMNLTDNEVTQSQVTHSPVTQSQVTHSPVTQSWVTHSPVTQSRVSQSRVTQSLVTQSWLMQSLVTQSPVTESRVSQSRVTQSRAHPKTDTIQVLEPLESHLYPPDEEEEETKPLTPPSLNGIVLGEDQEKGVLCPKYPRLSRACSALVEFIQRPLFDGIIAGLILLNTVVLTMYYHGMPDDLTFVLDILNAIFTGLFILEMIVKIFAFGLVKYICNKWNLFDSVIIITSAVAYFLGTSTGVSIFRILRLLRVLYLAQSWETMAKLIRAIAHSVDPIFNITCILGVIIYVFAVVGMRVFGPHYTAEAFGSRGIPRWNFTDFTHSFMMVFRILCSEWVEPLWDCMRVTNTAALLFFLPALIVGNFIVLNLFVALLLNSFAKKEEDLHREASEQPYVNPCSCLAHLTRTRKTRMYYTQAVNNNKNTKRYIVEIDDCFPECCMNACGCTSGQQHFCWLKFRCRVRCFVEHRYFEWFILFTVMVSSFTLVFEDIHLHQKPDLERALNFLNFLFAAIFSLEFILKVIGFGFVSYFTSVWNCLDALIVSVCVSVACLFENPNLSVFRSFRTVRGLRPLRAISRLGGMKVVINALFAAIPGIGSVLVVSMLFWLMFSISGVQLFAGKFYKCVNAEDEKLSPSVIPNKTACLDHPDYRWVNANVNFDNVINGFLALLQVATYEGWMEVMADAVDSTKIDQQPSYEANLIAYAYFVVFIIVGSFFVLNLFVGVIIDNFNTLKKKYEEINSMGMLLTESQRKWVQILMAAAKRKPPSNRLRPTDCFRGKLFDLVSSNQFEVFILTVIMCNMGMMMVQHYDQPPLTTVIGNYVLVGIFLLEAIIKIIAMRLHYFKKAWSIFDFVVVVSSIVGMYLGMSTESAVVSPGLLRVLRVFRVARLLRVVQFAKRIRQLLVAIIISMPALFNIGTLLFLVMFIYAIIGMSSFGNIKKQGALNDLVNFETFSSSIILIFRLGTGTGWNDILDALVVQPPHCDPNFGGLPNGNCGFPIGAVFYLVTYIVSVFLIIVNMYIAVLLDNVNRAHENDEFGLSKDKFKSYYHTFANFSMGKQFLPLRVLPEFLAALDKPFKIAHPSEELIRKMKIPVREGDLVHCFDLLKVLVKKILEQHGESPEVFEQITIRMEAQFRKSFTKKVSAAIIGSTML
The following text describes a protein:
Function:
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MSGFAFSAGGERFRFADLKDLLAKATPARSGDQLAGLAAHSELQRVAAQMALAELPLRHFLDEAVVPYESDEVTRLIVDQHDAAAFAPVAHLTVGGFRDWLLGAQADDAALAALAPGLMPEMVAAVSKLMRVQDLILVAQKTRVVTRFRNTLGLRGRLSTRLQPNHPTDDATGIAASVLDGLLYGNGDAVIGINPASDSLAATTALLRMLDAVITGYGIPTQACVLAHITTTIDAINRGVPVDLVFQSIAGTEAANTSFGINLALLQGGLDAGLSQQRGSVGNNVMYFETGQGSALSANAHHGVDQQTCEVRAYAVARQFNPLLVNTVVGFIGPEYLYDGKQIIRAGLEDHFCGKLLGVPMGCDICYTNHAEADQDDMDMLLTLLGTAGINFIMGIPGSDDVMLNYQTTSFHDALYARQALGLRPAPEFEHWLDTQGILRLRDGRFELGSEMPAPFRKALSQLDAEQRG
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MKKPKPTLLSPNWVQLQEKLKPNGSKASRTFKNSDEDTPESILGKRKERPDDEPNDCQINPLAPINDDSSLTDAVAMDCEMVGVGQGNKSALGRVTLVNKWGNVIYDEFVRPIERVVDFRTKISGIRPRDLRKAKDFWAAQKKVAELINGRILVGHALSNDLKALLLSHPRKDIRDTSEYRPFLNRSSSRRALRHLAAEHLGVNIQTGEHCPVEDARAAMLLYQRNRKEWEKNIKDQFRLKQKQRKSKQKKKQKNEDVSNANHVEI
The following text describes a protein:
Function:
Inclusion membrane protein probably involved in early modification events of the chlamydial inclusion (By similarity). Binds to the host cell 14-3-3 beta (YWHAB); phosphorylation of Ser-166 is probably required (By similarity).
Subcellular Localization:
Secreted. Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane; Multi-pass membrane protein. Note=Secreted, probably by a type III secretion system (By similarity). Localized in the inclusion membrane (By similarity).
Sequence:
MICCDKVLSSVQSMPVIDKCSVTKCLQTAKQAAVLALSLFAVFASGSLSILSAAVLFSGTAAVLPYLLILTTALLGFVCAVIVLLRNLSAVVQSCKKRSPEEIEGAARPSDQQESGGRLSEESASPQASPTSSTFGLESALRSIGDSVSGAFDDINKDNSRSRSHSF
The following text describes a protein:
Function:
Promotes the assembly of newly synthesized U4 snRNA into the U4/U6 snRNP particle. Required for splicing of pre-mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 167 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MEVDNKRRHSEDELKQEAVKKIKSQEPNYAYLETVVREKLDFDSEKICCITLSPLNVYCCLVCGHYYQGRHEKSPAFIHSIDENHHVFLNLTSLKFYMLPQNVQILHDGEVQLLNSIKFAAYPTYCPKDLEDFPRQCFDLSNRTYLNGFIGFTNAATYDYAHSVLLLISHMVPVRDHFLLNHFDNQGEFIKRLSICVKKIWSPKLFKHHLSVDDFVSYLKVREGLNLNPIDPRLFLLWLFNKICSSSNDLKSILNHSCKGKVKIAKVENKPEASESVTGKVIVKPFWVLTLDLPEFSPFEDGNSVDDLPQINITKLLTKFTKSRSSSTSTVFELTRLPQFLIFHFNRFDRNSDHPVKNRNQTLVEFSSELEILHVKYRLKANVVHVVIKQPSTDGNAFNGDEKSHWITQLYDNKSEKWIEIDGINTTEREAELLFLKETFIQVWEKQE
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
Sequence:
MECLQVWTAGLMTTLAFFIVTMHESGLPRVVAHRLDHADGVNKESHVVLTRQKREWQWNFLYVEEEKPAPVPYKIGQLKSSKKDSTMNFEIEGEGANSIFTVDRGGDLFVTTSLDREKKASYNLTARMYDKDNNLVEDAGHFVIHVTDINDNSPVFSQTFNGYIMERSKIGTFVTKVTATDADDPSTANGVLKYSLAKGGDVSAFSISETTGEISCKVNTLDRESRSQYTVVVKAQDLRGLASGITATTSVTITITDANDNTPSFRKPKYEMKAPENHKLNEVIDTLLVDDRDELKNKKPVFRILKEEYNKVFGIQLDSNKNGNLVLKQALDYEKTQRYTFTVQVKEDLEFPADNLNTAITSAQVTVEVTDVDEPPVFSETVYTFKVLEEHIVDQIGIIKASDPDRANKSIRYSIEEEGCPISVHPIKGQLSTVRRLDRELQATHVFHVKAREEPDGLESVVRVHIDVQDYNDHEPELDDVDAFVCENDTTNTVIGTLKANDEDDQPATFTFSLASPSSNFSIKDFGNSSAVILVKQGPFSVDDPKEYSVDVRISDGGQPVKTSVTKLAIKSCRCDAGRITKYCKPGARRMGVSFHALIAILLCIITILVIVILFAVRKRYQKDSLASMKNSGEIHEQLVTYDEEGGGEMDTNGYDVSILSSACQDGSLLRHSDHHAHPSLYAMVQKSQHRPQAPACKGDMAAMIEVKKDEADHDRDGFPYDTLHIYGYEGPESLAGSLSSLESSSSGSNLDYDFLNDWGPRFKALAELYGVDSSDYYHQY
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase in vitro.
Sequence:
MAAAASASSPVEFLLRRPAPRRRRLPLAGAFFAPTGLAGATLLRAVASLAASLVAGARPPSQRRNVDALARRLALLSAILESILLDTAAAGAFSDAANLCFRELYVVLFRAELLVSYVASAGRAWALLRSPHLAASFRDLDAELAVVLDVLPAASLRLSHDATGLLDLLRAHCRCRAPAQYHDPDEAALRERLMDALRQFDLGQPPDHPSLQSLLADMGISTAASCRAEIDYLEEQILSQEEDTDLPLVGSVLALLRYCLFAVFDPSNAKALRDWPLSGNRQRLLSIGGGDDTSFSVPKEFSCPISLDLMRDPVVASTGQTYDRPSIIQWIEEGHSTCPNSGQTLADHRLVPNRALRSLISQWCGVYGLQYDSPESNEGMAECVAASCSSRAAMEANKATARILVRMLEDGSENVKAVAAKEIRLLAKTGKQNRAFIADLGAIPLLCRLLLSNDWMAQENAVTALLNLSIFEPNKGRIMEQEGCLRLIVGVLQNGWTTEAKENAAATLFSLSVVHNFKKLIMNEPGAVEELASMLTKGTSRGKKDAVMALFNLSTHPESSARMLESCAVVALIQSLRNDTVSEEAAGALALLMKQPSIVHLVGSSETVITSLVGLMRRGTPKGKENAVSALYEICRRGGSALVQRVAKIPGLNTVIQTITLNGTKRAKKKASLIVKMCQRSQMPSAMALGSTLTVVDRSLVGNNTLRRAASFGSGELSNPISISVQVP
The following text describes a protein:
Function:
Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues.
Subcellular Localization:
Nucleus.
Domain:
The QLQ domain and WRC domain may be involved in protein-protein interaction and DNA-binding, respectively.
Sequence:
MATRIPFTESQWEELENQALVFKYLAANMPVPPHLLFLIKRPFLFSSSSSSSSSSSFFSPTLSPHFGWNVYEMGMGRKIDAEPGRCRRTDGKKWRCSKEAYPDSKYCERHMHRGKNRSSSRKPPPTQFTPNLFLDSSSRRRRSGYMDDFFSIEPSGSIKSCSGSAMEDNDDGSCRGINNEEKQPDRHCFILGTDLRTRERPLMLEEKLKQRDHDNEEEQGSKRFYRFLDEWPSSKSSVSTSLFI
The following text describes a protein:
Function:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes.
Domain:
Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably plays a role in the specificity for G-protein coupling.
Sequence:
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
The following text describes a protein:
Function:
This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It binds to GAL4 and so blocks transcriptional activation by it, in the absence of an inducing sugar.
Miscellaneous:
MISCELLANEOUS: Present with 784 molecules/cell in log phase SD medium.
Sequence:
MDYNKRSSVSTVPNAAPIRVGFVGLNAAKGWAIKTHYPAILQLSSQFQITALYSPKIETSIATIQRLKLSNATAFPTLESFASSSTIDMIVIAIQVASHYEVVMPLLEFSKNNPNLKYLFVEWALACSLDQAESIYKAAAERGVQTIISLQGRKSPYILRAKELISQGYIGDINSIEIAGNGGWYGYERPVKSPKYIYEIGNGVDLVTTTFGHTIDILQYMTSSYFSRINAMVFNNIPEQELIDERGNRLGQRVPKTVPDHLLFQGTLLNGNVPVSCSFKGGKPTKKFTKNLVIDIHGTKGDLKLEGDAGFAEISNLVLYYSGTRANDFPLANGQQAPLDPGYDAGKEIMEVYHLRNYNAIVGNIHRLYQSISDFHFNTKKIPELPSQFVMQGFDFEGFPTLMDALILHRLIESVYKSNMMGSTLNVSNISHYSL
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MQFGCNVAEAFGLRRSGVVLLTDQSLRSMPLSQQKKVEIILDGMGRGSQAAQGLPSPITSLAFIRDSHHFLFLAVDEDQCLGILKGGIKHLFMLDSQNETHEMDAMCCLDFYTHETVQRRGIGTRLFRAMELHTHISAQGWAFDRPSPKLLAFLSKVYDMHDFKAQPNNFLMLDASIRLWGAEFKQYRRSKKHYIPDAYLLPETRESEYLGEAELTKRTLIRKSTAVIPQTKTTQSEDAPARALTADELLSKRSVVLPTASRTPSLPDQPQSVAAAYMNKRIEGAGPSFEQYMRDHYGAKSLIVPSEIQTSLNHSKDSVSQEDMIQRQRQLDRMAFTLAREANARGSIHNTVGRGVICGRRG
The following text describes a protein:
Function:
Poorly processive, error-prone DNA polymerase involved in translesion repair and untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by Pol IV. Exhibits no 3'-5' exonuclease (proofreading) activity. Overexpression of Pol IV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. Not seen to be involved in translesion snythesis even when stimulated by the beta slding-clamp and clamp-loading complex, which do however increase non-targeted DNA polymerase efficiency 3,000-fold, may be due to targeting to stalled replication forks on nondamaged DNA. Involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
Subcellular Localization:
Cytoplasm.
Domain:
The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity. It lacks the O helices present in high-fidelity DNA polymerases in the fingers domain (By similarity).
Sequence:
MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARKFGVRSAMPTGMALKLCPHLTLLPGRFDAYKEASNHIREIFSRYTSRIEPLSLDEAYLDVTDSVHCHGSATLIAQEIRQTIFNELQLTASAGVAPVKFLAKIASDMNKPNGQFVITPAEVPAFLQTLPLAKIPGVGKVSAAKLEAMGLRTCGDVQKCDLVMLLKRFGKFGRILWERSQGIDERDVNSERLRKSVGVERTMAEDIHHWSECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFDDFQQTTQEHVWPRLNKADLIATARKTWDERRGGRGVRLVGLHVTLLDPQMERQLVLGL
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.
Sequence:
MADDRNEFEQIDDDSFDMLSLRNILLKDNHNVDNIVLFLYQSLRQTGNKGRPFSLKTVTKIVNFLLELVSTEVKENVQKKYFDDKYVLERLTSLMVRCQKVVQSARSSVPYLSNDQLDGVSFKELLVSMCSLLHGCLNKTNYLMNDSIYNSYIKIATLALQFVSNVVCLKNECHQIVLAVLLVILIELIKNESMFDKSFNSTTKALLYNCIAKSADAFILLKKYAKNKFTHDNADDEGDGAAATEAAADDNDKAGGNDNDDIVCLSHTLLSSIVKKSEEDDDDDEDVCEWSLFIVEKLLKSCGFLRFIWPHLSFIEKHLVLDLLHNECEQLKVLETTTTSTAFTNTIAAATAATATASTATTTTTAANLAETSREKFESHFNVDALRFLIELILKSYDNDDRNNGVGANNDHSDGGDILKRMLKSGPSNAHISSVKRNALSLVANITFKNKTLQDLLRGKGGIEAILNMTAIDKFCPTNQQWALLAIHSLCVGNPENQEYISKLKVERVSELNNDLRSVGVNVKVVDGRLRFESS
The following text describes a protein:
Function:
Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MYKSVINIVLFCPEIPNNTGNIVRSCTAFKANLHLIKPYGFFLNDKRMVRAGLNCWDKIQLFEHKSWEHFLQATTENKTIWLLTKSGDKTPDQICMTNKLPNELYFVFGQETKGLPKTIMDNFKQNQIRIPIWNSVRSINLANAVVCILYEYSKQNQYSNLDKQCA