lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Cell projection, cilium. Cell projection, axon. Cell projection, dendrite. Perikaryon. Endoplasmic reticulum membrane. Note=Synthesized in the endoplasmic reticulum, and then packaged into vesicles that are transported to the ciliary base and inserted into the ciliary membrane. Localizes to both the ciliary base and cilium proper.
Domain:
The transmembrane domains are sufficient for localization in the cilium. The cytoplasmic tails are necessary for localization in cell bodies and anchoring at the ciliary base. Cytoplasmic tails also regulate sensory function.
Sequence:
MNYGAADERWANPPQPVAAAEHGPSFDHSMVSEEYEHDKKKNPAQKEGISFSQALLASGHEKSDGKIKLTARSFMEVGGYAVFLIVLVYVAFAQNSIQSYYYSKVMSDLFVASTGASGAPAFGSCTSMDNIWDWLSQVLIPGIYWTETSNSTDNENMIYYENRLLGEPRIRMLKVTNDSCTVMKSFQREIKECFANYEEKLEDKTMVGDGSVDAFIYATAKELENLKTVGTIASYGGGGFVQRLPVAGSTEAQSAIATLKANRWIDRGSRAIIVDFALYNANINLFCVVKLLFELPASGGVITTPKLMTYDLLTYQTSGGTRMMIFEGIFCGFILYFIFEELFAIGRHRLHYLTQFWNLVDVVLLGFSVATIILSVNRTKTGVNRVNSVIENGLTNAPFDDVTSSENSYLNIKACVVFVAWVKVFKFISVNKTMSQLSSTLTRSAKDIGGFAVMFAVFFFAFAQFGYLCFGTQIADYSNLYNSAFALLRLILGDFNFSALESCNRFFGPAFFIAYVFFVSFILLNMFLAIINDSYVEVKAELARKKDGEGILDWFMNKVRGLTKRGKRPDAPGEDATYEDYKLMLYRAGYAEKDINEAFTRFNVTSMTEHVPEKVAEDIADEVARMTEQKRNYMENHRDYANLNRRVDQMQESVFSIVDRIEGVNATLQTIEKQRVQQQDGGNLMDLSALLTNQVRNRESAARRPTITSIADKKEE
The following text describes a protein:
Function:
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
Subcellular Localization:
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Sequence:
MDIGLREWLIVIGLIVIAGILFDGWRRMRGGKGKLKFKLDRSFANLPDDDGDSAELLGPARVVEHREPSFDEQDLPSVSAREAKERKGGKRQEEPRQGDLDLDEGLALEADPSDAAETVEPRKGKSKGRKEKEREKAPAVAAEPAPVDEVLIINVIARDESGFKGPALLQNILESGLRFGDMDIFHRHESMAGNGEILFSMANAVKPGTFDLDDIDNFSTRAVSFFLGLPGPRHPKQAFDVMVAAARKLAHELNGELKDEQRSVLTAQTIEHYRQRIIDHERRSLMQKR
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
PVPAAPQRAAPTQLQARVSSPPTAAVGRGDSVRGPWSEAEGVEETAPPTGPSAPPTREGRSRSGVGRRGRAVPGARRAGLPGGSGSGGEDGGGGDGREFTLPFKTWRHWPTQSLADFRKEESSKMSSKTASTNSTAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLMGIPTSENPFKDKKTCIIL
The following text describes a protein:
Function:
Promotes the exchange of Ran(spi1)-bound GDP by GTP. Involved in the control of mitosis. Regulates a variety of nuclear events, including mitotic check-point, chromosome decondensation and mRNA processing/transport.
Subcellular Localization:
Nucleus.
Sequence:
MTSNRSTRSSTKREEVSKNGVEKRELDESDVMKNGKKPVKRAKVSSLPKPVRVPGSAKRINKIPELPTERLNVYVFGSGSMNELGMGEEEMDVVYRPRLNPILSTDKVGVVDLAVGGMHSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPEICQLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISVGAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLTNVIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKEVAIRVAGAGGQFSIIAGIPNASEEPVANGIKSEPENEKKLKTEETSKTDDSPVTDAKPDVTSNGEPSTATSESKDSVLEPSSTTA
The following text describes a protein:
Function:
Appears to have a role in sporulation.
Subcellular Localization:
Nucleus.
Sequence:
MDFRITEGSSPTSLSVSEKIAKLESCNDSRITCRPVRESKPTYTSGQKHSALLSKLKRSKVTTDFCKLEESKGIICQENLHTEGAKSKTENISGEDKSSQRRTRLKQIQEFISHRRSFLNSNANSVESEKILAENNHMFNVKSKLSNKESFIKTRRPRTNGELSDLSLQPKRIFSEPVNSHPSQSMFGNGVRASSGSYSLKRDLKDYEEELPSSKKRQRTPPPIVVTNFPQEIFPSKKISLSAKRRIQGKYSGENVRARIELARERNRKRDYVSNLSKGHTTNALEENPFNLGPNYRASTRKCNRIKEAINLFAAKNGSMEVPPKVSVGDSVLTTSQKFLQVIREKTALLMNQDSNSVQPQALAAAESPTTKAPTTKAPTSEAPPKGHVKQLAKQLGNIYMPQSINNVEPTSHSSISKVVNPSEKVISKIERACLAGNGNVHPSIKMEKNLELNPHPRTLNATEHKINSRIQVSKLNTKNELANADPKMYLLENLSDRLYFCKLAKLLLRKYPLDIAEHQFALVYSRFQRIPLKQISCLKQSLVAYYSVLSEVGITNEIMLRENRFSSPKTPEGLVSISKLLLDDREHLSHDERSYIQQLQSQIKSQSVHHENAAEEIRKMRNLRNSRINSQQVGEKVFVNPDVKTMDIQETFLQDYEDETFANEGLSASKFKEEFLLISDSKSDLNSEEIATPNSLEFKNNPRIKVPRSLLTILNLHDRSQLKLFEVCHNSEFKDPINLSNCLRNLLEKQLLSYNFTDWFASLGSEYENVYVKFISHYDFSSLNVYASFQKLCCDLYYGSDDYIHSPILQVFASCWLKQNSNYGFLNEDIIVKIVLILIDLHKSTYSKKLNSYVVPMETFVKYALEKLRPLISPDSVCILSKEDKKHWLKYKKNRSTFAKLLFSTWSNLPSDIGFILECMLKEYYDTFLKSPFAVPNAVQAQLHNQVRGDLTPKRNRSSLISELMKSSKLLKQESSGNKNSTSLESDAFKESSFVLNEENGGIYAGKEIDLPEPSVIDGRPHFSVFNYTHHMQEEKTHNRLPWHRRGMISYKKMVLSKNNRWVAGYWKKKYCIVDSGKLIFYKSDHLDPNACSNVSPIHREFGLQSCLASPNLPPSINSNRNNVFYLNIPGNECYLFEAPSVLAMNEWIHSLNFNAAMITCPPLPENITNTEYGWGYILTRAEKKAYYTAADGTKTFVGDLAQLTRWSPMDIQGLQDIPRPLRDKVHILRDCVPSLLETCLLFQSLPEKMEKCFAAGSKNYLKAMDNWNRKMKFLYERSMMYKEYQRVLECEYEYRKSHDFYPTLSPVRYPYDFKGL
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The DWD box is required for interaction with DDB1A.
Sequence:
MSLSQNAPKSKGIKREELKKQYEDVEDEEEIGSDDDLTRGKRRKTEKEKQKLEESELVEMKKLENLIFGSLYSPVTFGKEEEEDGSALFHVDRSAVRQIPDYEDDGDDDEELSDEENGQVVAIRKGEAAWEDEEEKQINVDIASVNRLRKLRKEENEGLISGSEYIARLRAHHAKLNPGTDWARPDSQIVDGESSDDDDTQDGGVDDILRTNEDLVVKSRGNKLCAGRLEYSKLVDANAADPSNGPINSVHFHQNAQLLLTAGLDRRLRFFQIDGKRNTKIQSIFLEDCPIRKAAFLPNGSQVIVSGRRKFFYSFDLEKAKFDKIGPLVGREEKSLEYFEVSQDSNTIAFVGNEGYILLVSTKTKELIGTLKMNGSVRSLAFSEDGKHLLSSGGDGQVYVWDLRTMKCLYKGVDEGSTCGTSLCSSLNGALFASGTDRGIVNIYKKSEFVGGKRKPIKTVDNLTSKIDFMKFNHDAQILAIVSTMNKNSVKLVHVPSLTVFSNWPPPNSTMHYPRCLDFSPGSGFMAMGNAAGKVLLYKLHHYQNA
The following text describes a protein:
Function:
[Isoform 1]: Paired-like homeobox transcription factor involved in embryogenesis. May act as a regulator of embryo genome activation. Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos; [Isoform 2]: Inactive transcriptional activity.
Subcellular Localization:
Nucleus.
Domain:
[Isoform 1]: The homeobox contain essential residues (Ile-54, Lys-57, Ala-61) for binding to the 5'-TAATCC-3' motif of the targe gene promoters; [Isoform 2]: The homeobox is incomplete and cannot bind to the 36 bp motif found in the promoters of the target genes; The 9aaTAD motif is a conserved putative nine amino acid transactivation motifs in C-terminus of the LEUTX region.
Sequence:
MFEGPRRYRRPRTRFLSKQLTALRELLEKTMHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWKRQQRQQMQTRPSLGPANQTTSVKKEETPSAITTANIRPVSPGISDANDHDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV
The following text describes a protein:
Function:
Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with ADORA2A at neuronal processes. Colocalizes with and tracks the tips of microtubule plus ends (By similarity).
Sequence:
MSQHVGHGRKPRTPGPPVRSIRPFKSSEQYLEVMKEDLAEWLRDLYGLDIDAANFLRVLETGLVLCRHANTVTEAALAFLAEAPERVQKIPMPQVGVFCNGAAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGVAAPSLVYLEEEIEEELRRDLDLPSPDPPPPVPPARRPCHFHNLDQMVQSLVSHCTCPVQFSMVKISDGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHKPGSFLKPPGPPVQHEVKVQDGPSQPQPLMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSSGPRSEFPARARTPREMAPFLRSQEKPTLSQRMSSPGPQLSSPCRGPDLQSTLSERRVNRSPGELPRGRTPTSWVPKEADSQGAHTKAPIPQRLQIPETTSKKTPARGPSPPPRSSSLASPHTIWLPDQGASPEISEPMSAQSSSPGKGLTKIPIRLSPARPPTPGRGSLGTEGGGSMQRGSLSSRALAGNLDRSTHGHHSVDVSKDHQKVIQISSGTEDPRSLGTQERKERYTSLPLGRTREPALYDNLKEELVANMKLLEVGAACTQGTRSQAIPRSGVYVPSLGGMWPEPRGPYDKVIQELVQGPPRLLKVDLKAWKVGSECLPRPIVNPGSPKEEQVSRERGTRRKARPSAQGTTVKTTSPARGQDCSTLPVSANLKAPTHSCSDPSSDKAKVCLGKGKRTLRKPQKVPSIYKLKLRPRIRPRRDHRPEKRPSRIPKPLVYPFLGPARTAPGSRLLKATLGGTGGDVNGVGKKEEEKKKETSISLESSIQPSESREPMQLDGTPLPPEEESWV
The following text describes a protein:
Function:
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGENKFDGLSFFENNEFQNMNFIRGSMDNNRNEEEKGLIQKAIDLSKKGAETLQKGLKETLGKNNMNDGASMVSNSTTAESGSMFSNFPLFNNNNQNRENETSSFFAFTTLVSYKNFPLFCILFGISVLFMILSFFTLPMIVITPRQFGFFFTVSSICFVSSLAFLKGFSNLYHHLMEKQRLPFTTAYILSLLSTLYFTLINPLYLLALITSVIQMLALISFLVSYIPGGAGAIKMLINAIYSYVKNLFRRSNTSDLPF
The following text describes a protein:
Function:
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Sequence:
MKKEKHLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCGIEFKECLGIDPSNNMLELAIKKCEELENKASFIQAQAKDLKGVENNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVLVILEFLKKDNPTWLDKISGFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELRNAGFEILRTEDSIAQISTTMLVKKN
The following text describes a protein:
Function:
Cleaves SYN1, releasing sister chromatid cohesion. Required for the release of cohesin at anaphase I and anaphase II, whereas the release of cohesin during diplotene and diakinesis occurs in a separase-independent process. Essential for embryo and endosperm development. May play a role in centromeric heterochromatin structure/formation during early meiosis, non-homologous centromere association and radial microtubule system (RMS) formation. May regulate the mitosis-specific cyclin CYCB1-1.
Sequence:
MASSGDDLRLLSLIDVGDNVFSSFSDYLKPFSTLSTSRKKQDRATTIRALAKQFLPFLNKSISLLPKRLSVANSDKEARESALDLFRAYELCLDCLELVSAQLACKPHTVQSQRLRMIHCLDVWGLYENVYTEAFKVLEKLRGSDSKSRKSRLLPEVQDGDAEMALVVVDAVAAIFRAVAMSQQLDDKRYRKVLLLLEEVGGWLRVLDAKVYEKLHRAMVTSMGKCAVSLVREAERFNGDLVISFCDLTVKEHYKSALSKDRVYKFAREVLSVLFGFKDRKMSVTIDISMSVLRSLSCQFEDESNENLMEFFDLVDYCAHKFRAAGDMYCAKVSKKLNEMAAIFVEAIPQLNLVLRLYSTGLSITVCNSKLGEIKLEDSTDDWKIQAMFDDDARWQSLVSLLGMVDSYSGDEGNQTGSSSIGGHRNYNNKTHDSCKDRNKITCWPQYVDALKFLCQPLADFIYSVKRKIVLETEMSCASAHLITIHDAFLQFCDGCLFLQRCTSDKGDREIANNKAFLNAAMGAFIVSLRTQLKLEISAHLVEDVIGSPWIQSQELKYLIATLYNIGIVLYRNKELNKACEALKLCSKVSWRCVELHCHMFVNQSSSSDNDLSEDAIMDFVGEACNRCAFYLDILQKCSRRKIRQNIVHILENWLSAEHLIRRLPGPEAIVKQWVKIERECHTDLDAAGSCTTLYSLLSSSQKKSKRGIGKILEQELLAYDRVLPLRSNLGQQTRIKIADILLKDVYVTEDMHIERARILIWKARMTRTSGTEHITECICFLSEAISILGELHHGPNEEGSPSSHMLPIAYCLRAFCTQEADPNSKKVFQDISTSLNLWLRILSLDDSGDSLPTENIIPLLYNMIDLMSVKGCTELHHHIYQLIFRLFKWKNVKLEVCLAMLWECRRLSHALCPSPISDAFIQTLSENCADKSTCIDFWMDCLKDSKAKLIGFQQNFHDLHNKDEGPFQSDITIDDIKDAASELISSASLSGNSSFAAAYLYYDLCERLISFGKLSEALSYAKEAYRIRTLIFQDKFKYTAEKHIEKHNEDGKISEIRTFSIKNFQVYRLLATDFWPCGNFLWDINRCYLSPWSVLQCYLESTLQVGILNELIGNGLEAETILSWGKAFSCSQSLFPFVVAFSSALGNLYHKKQCLDLAEKELQNAKEILIANQRDFSCVKCKLKLEVTLDKQLGDISRKQIDRVSQTDGFLHAESLFSAALGKFCCSAWKSCIRSHGEEIAEEIVIDRNGGEGLGHNSSKTKLSIKEPPGNRGSRRGGRANKTCLSKDQDLISEPTSRLTRSMRHSLREQCQNRSNVPEVVSKKPNLCDRSVGSRGERVLLDTSNALPGFCICYKEKRQQCLSEEVTESGSLNNLVSLKWELCHRKLASSILVSLGKCLGDSGRIHLAHEALLHSISVLFKSTWSSHNQPSVSQLLEFIGKEVTRDVFAVDRAIILYNLCWLNLRNYHCRKSRSICCDLFHIPFTKLVSWLMLAFVLSGEVPILFQKVSRLLASLYLLSSSNSEFTFESDGNELSASHWVSFFHQASLGTHLSYHFISNLSQKHKSQCLSDKECTEATCSSCMVPEDLDLPRLAPDRTQDLVQFAKEFFINLPSSTIICISLLGGALNQLLQELMHIRSPVCAWVLISRLNPESQPVATLLPVDSIVEDMSDDSANLSSTEATQVKSLKGPWLCPWGTTVVDEVAPAFKSILEESHSSSSTTEEDTIESRGLWWKKRKKLNHRLGIFLRNLEASWLGPWRCLLLGEWSNYKLPDSAQKKLVNDLKSKCKMEVNEMLLKVILGGGTDNFKGEACVAQLSLRNGCYVGRGGYLYEEDSCKTPTAASNISESRHELALKLIHDAASKLGQQDGHENREPIILVLDPEVQMLPWENIPILRKQEVYRMPSVGCISAVLKKRSLQGEPAKSHVASFPLIDPLDSFYLLNPGGDLTDTQVTFESWFRDQNFEGKAGSEPSAIELTEALETHDLFLYFGHGSGAQYIPRREIEKLDNCSATFLMGCSSGSLWLKGCYIPQGVPLSYLLGGSPAIVATLWDVTDRDIDRFGKALLEAWLQERSDSSSEGGCSQCESLANDLAAMTLKGTKRSRKPSSRNKPAQSDVDGSGKIECNHKHRRKIGSFIAAARDACNLQYLIGAAPVCYGVPTGITRKKGIDALLPSSSR
The following text describes a protein:
Function:
Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Deconjugates SUMO2 from KAT5. Catalyzes desumoylation of MRE11.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Note=Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).
Sequence:
MKETIQGTGSWGPEPPGPGIPPAYSSPRRERLRWPPPPKPRLKSGGGFGPDPGSGTTVPARRLPVPRPSFDASASEEEEEEEEEEDEDEEEEVAAWRLPPRWSQLGTSQRPRPSRPTHRKTCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGRHRGRRRGLAHPKNHLSPQQGGATPQVPSPCCRFDSPRGPPPPRLGLLGALMAEDGVRGSPPVPSGPPMEEDGLRWTPKSPLDPDSGLLSCTLPNGFGGQSGPEGERSLAPPDASILISNVCSIGDHVAQELFQGSDLGMAEEAERPGEKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPLSTDEVVEKLEDIFQQEFSTPSRKGLVLQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPEKVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLISVDVRRRTITYFDSQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQGWKGYFKMNVARQNNDSDCGAFVLQYCKHLALSQPFSFTQQDMPKLRRQIYKELCHCKLTV
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MTSLIRLARHASFAPVLVACLALFILMVMTFCDVILRSVLNAPIEAATELTRILMAVLVFSVLPIISVNNGQIAVDLTDGLFHRLRLDRIRDGLIHLVSGIMLYWPMSRVWILAERSRDYGDVTEYLAIPTYIVGWFIAISVGISAVALVITGLLHLFAPRLLSEALK
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE. Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4. The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide. Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol. Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation. Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional.
Miscellaneous:
MISCELLANEOUS: In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAMGNPELRTHFFRSSHEPGIPNSLRFPNGFLVTCGLPWLLLLFSVTIILFHPLRKKSDLPLINPGKGRIGILRGYRSRKTFTTELPRLVADGLSKASAFRIAAPDGVNIVLAPSYAHEIAEHPDLNPGPIAGDEFNSHINGFEVFAQLGTSDVISESVRTRLTRQLTKLTPLLTSETPLLLQSQWKDAPDWVEVSPHETALFILSRLSSLVFVGDDLGRNPDWIRILTSYNTEAFAAAEELNLWPQILRPLIARLKPSCRQLRRYIRDARALLVPVLEQRRHAQSQGDRREYNDAIEWLDETSRSTGQPYDPILSQMLLAIGSFHTSSDLLGQVLLDLCMRPDWKVLVRELRKEIISSLQGEGWDKIALNNLKLMDSVLKESQRLKPASTVTMGRYASREITLSDGTIIPKGSTVFIANVAMRDSNIYPDPDDFVPDRFTTRREKGDSSAYLVSASPEHLGFGLGRHACPGRFFAANELKIVLSHMLMKYDIKLPDNGAVAPSKSGIFLATNPDARICVRRRKEEIVI
The following text describes a protein:
Function:
Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5.
Subcellular Localization:
Nucleus.
Sequence:
MSTAIYYSTHNNMHTNDDITNGSGSTTSGNPGANPSNPNHTNAGATINNNSNIGLNSANKNHTTLLPSLAHIMPSNSNNTTNSGSSIDISSTLINPYSSGAAAAAAAVGGGNGGYYHPPPPHSQQQQQQQFDTSYSNQTTPTSAYTNFNNDSTHSPTDISMQQNMNNLASSSGNMSIGGGIDGNFSHNNNNNNNNNNNNNNKCICKSKVNKIPRPRNAFILFRQKYHQMVLDEGTVIRTNPEVSRELGRRWRGLSPQEKEHWNNLAEEEKKNHAKKYPGYRYTPRRNGRNKNCPVCKNKPLPNNKSNSISGMSGSGGGGGSISGASSLSGGLTSRDNSITNANAIDYQQQQLQQQQQQQQQQAIQFQSLPPDQYQQLIKQQQQQLQLQAQLNGGGGGGGITSNPQTIPQYITNGNYPSYIISPNPYSTTSTTAPTTTTTTTTNASSIGLSVPPTATTTSTSSQPTSANSQLHFYEAEKLSPVSSTHHQSSISEIAAQQQQQQQQQQFMYNTNYSTIPPNNTTTMQQHSAGTGNDYSLNGNNSGNTGYDNRYGYGQPMIITGQSQQGLQVQQQGQHYNSGLHAAQHYQQQQQQHHQQQPPQ
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Zona pellucida.
Sequence:
SSSPSSAMEKSGNQKCLVSDNDKVVCGDPTVTRADCEAGNCCFDQTSQRRCYYGNDVTVQCTRDGQFVVVVSRNATSPXMFKFPVSACGTRMRVEAGAVVYENLMNSSFEVRSGPDGSITRDSAYRLFFQCRYADDELVPLQAVVYTVSPPPPAVSPGPLRVELQLARGTCAEPSGEQYDSYYSEGDYPVTKVLQDPVYVEVHILQRTDPNIVLTLGDCWATSTPSPLSQPQWSLLVAGCPYRDDDYQTTLIPVGGSSGLLYPTHYQRFMVRMFTFVDPASQLPLKETVYIHCSAAVCQPTATDRCVPTCSRRRRAAAAARGGSSKDTAVVSSGEVILTASELPAQGEAHRLWSEVPQVFSYGLLAVAASTVLVVSALLLVAGWRFRPCTQNKAV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPPRLNVKCFTRSMPLRPQPRLQWSVRPATRFSVSQYRSYSDSKTSGANDRSAKVDAKPEDHVSQEAAKTAEIMGEQGPDLSRGTPVEDIVKNDKDAQEKLPKVMKDKLKANANAAPKGSRSYSTMTTQTSSQGLDMGLVDVQSAAKLPQIPGLKFEMPTLPLPKDGHVKRRYDPVVEQVTNLLMRHGEKSVAQSNMARILQHLRTSPIPTINPAKPLLPGAPPPSHLPLNPILYLTLAIDSVAPLMRIRSQRGAAGGGVALQIPVPMHLRQRRRTAIEWIMSNASKRRNVGSGKGSFAQRIAQELIAVVEGRSTVWDRRNALHKLGVAARANIVLPKKR
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MAIRHCFDKDVDQVLFEGNSCVKKVILNRPHKLNSLTYHMTCQMIKELKAYEVDPKVKIVILKGNGKAFCAGGDVLASYTCMVAGHWSYGTNFYKKQIMLDYLVATYGKPVVAIIDGIVMGGGAGLSLQGTFRIVTENTVFAMPETAIGHFTDVGSSYFLSRIPGFFGEYLGLTGAKIRGAEMVECGLATHFMLAKDARLLETALDEVTSTDTTTISEIISKFMHKPNVKQHGAFSRLEIINKCFSRTTVEEILSSLESEAGTESEKWILDAINWMKSACPTSLKISLRSIREGRKQGGPQART
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEAEADWDAEDFEPSVPVPVTTAIISDKWEGEDEDEPVKDSWEDEETENKPAEVKAAAAATKKKSSKRLEEKIAEKEKKSREEAEARKILQEANMTPEERIAEKLRRQKLVEESDFEMAKETFGITGSLPTEGSIDEANPLSKEEFSEFKNNLVKKLQSLSTKACYNDFIEDFIKDVCIGLEVEVLRKVSLTSKSLHEEKLKMVKAATKGGKKGKTKVALKMDKGMVDNFGDDFGGGDYDDFM
The following text describes a protein:
Function:
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKSKKGLVAASGSDSEDEDSMDSPLDLSSSAASGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISEASSIEAAMGIKNFMPTLEESPFHSCVVGPNPTLGRPVSPKPPSPGSILARPSVICHTTVTALKDGPFSLCQPIGVGQSTDVPQIAPSNFTDTSLVYPEDTCKSGPSPNPQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
The following text describes a protein:
Function:
Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine. Can dephosphorylate MAPK1.
Subcellular Localization:
Nucleus.
Sequence:
MVSRRPAQGYLTRTAAEGARSRPLRQRHRHESPGRGNERKEEEAPAAMGLEAARELECAALGALLREPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRARGPPAAVLACLLPDRALRTRLGRGELARAVVLDEGSASVAELRPDGPAHVLLAALLHETRAGPTAVFFLRGGFDGFQGCCPDLCSEAPAPALPPPAGSKTSCSDPRAPIYDQVSTAPRPGPFLPPHRRLGASRERACHLGMRAVCPCTHLYTCVCWGRWGHGCSHVPVWVCVRLHVYVGSVRGTCVPVCPPHIPESCLRSGGLAEDSSCLSQPMGSPPAAAPALRGWAAKASPSVCPLQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGIISPNFSFMGQLLQFETQVLCH
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
ALSELDATEASLSLPSWRWSYSYLEKIRSMSVVGSSSSSSSSRSARSSNYSSTVSSTESGAGSHRRRCKTGAASGGSFLRVVGFQVPGPRDIASQMVRDGFVLALIGAFGRAPGPVLERWFSELDVGWVLRPTDQQQQEEEEEEEAERLVWRWTRALTVMAHALSATQGHLHDERSAAAAAAAAVAVVGGVEFAISQPPHHTAPAVASSSDHELLLRGVVGGGDDLCLVRFTDTTISKMIAFAAALAAAGKAGTCPTPTADSFFGLMEVHTCISDVSEILMPALKQEALDLRLPDSEQMQSLVNKIGEAMANTQDSLGEAIRKTAKDAEAVTPVLSAMDSWEKFTQTEGIHRATRLIVDYASLFWGYRRVLESILCCYRSESSQNCWEIVQSLIEQMIITFLDQLEKKSESFSDPSLRYIFLINNSYFIQDQFLATNTDYSFPSSKGIRYWHYQNCYLDVSWEPVLSFLYLYNKMPKFFPKHSPQLLARFQSEFQKACRHQKLWKVPNTEHRNSLRKAISDKVITAYRKYLEGHLEPEKSSSDLLAMEDMVNELFEG