lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
Subcellular Localization:
Periplasm.
Sequence:
MRLHLTFNHSTPATGRKNTKHTLFFGSMLACIISIISLVVPAYGANVSDEKKAKPFTHDNVIDLAMQLAQKPFKEARKAPKELIDLDYATYGKINYQENAAIWGGTPTKFSVQLFAPGFLYKNLVDIDVVENSRAFPIELTESSFSVPNDTIEKLLTQVGQYAGVRLHYPINDDEVKDEFIMFQGASYFRALSKGQTYGLSNRGLAIDVAQPKGEEYPLFKRFWIERPSKYQTAIVVHALLDSQSVTGAYRFGIYPGAPTRVDVDVTLFPRRDIAHVGLAPLTSMFLYGGLDTPDKPDYRPAVHNSEGLQIDRGNGERLWRPLNNPNKLQISAFGDEDIKGFGLIQRHRNFDYYQDLGANYQQRPSAWIEPLNDWGKGQLILLEIPSNAETNDNIVAYWEPQGGLKQAEPYRYSYRITASNDSPSFTNKARVIRSSKGQKQAKGKELLIDYSNIKPQDIEKITIDASISKGKILSSRIVAHPEINGARIFITFEPESTNVAELRIQLRKDEKPVAATWLYRWNSDDWP
The following text describes a protein:
Function:
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.
Sequence:
MIPSKMMSANPEEDPLDTFFQYIEDMGMKAYDGLVIQNASDIARENDRLRNETKLAYLKEKNEKRRRQEETIKRIGGEVGRGQDASYAGKHFRMGFMTMPAPQDRLPHPCSSGFTVRSQSLHSVGGTEDDSSCGSRRQPPPKPKRDPSTKLSTSSETVNSTAASKSGRSLERAEGKFTVPASHSPPRASTSGHLFPSPGSQERNIKVSAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHVPRRTSLPRDSSLSQVCSPAADPEEEEPVYIEMVGNILRDFRKEEDDQSEAVYEEMKYPIFDDLGHDSKCDFDHHSCSSQCATPTVPDLDFVKSSGPCTPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPPGACPSSLPSHGSSHAKDQTGALGPAPGASILSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSSSVPHTTPRPVSQDGAKMVNAAVNTYSAAQSGSRSRTPTSPLEELTSLFTSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDSKERGHYGSSSSREPVKAQEWDGTPGPPVVTSRMGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQASDLQQSQVPSSLANRD
The following text describes a protein:
Function:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Sequence:
MLWRDVCEIFNKIEKTTKRLEKRDYFIKLIDMVKEKGKPEDLKKICYMAIGRVYPEYDERELGIGEKLLINAVTSIGIKKDELLEKIKETGDIGLAIEQLKSKIKQASLFFQPLTVDEVYETLKRVGEIEGEGSQKKKLRLISSLFLRASPIECRYLARLILEDMRIGMNVPTILDALSVYFNVPKEKLEKIYAITNDIGLLAEKLLMGDLESEELKLKLFRPIKPMLAQLTPSIEEALLEMGRAQFETKYDGARVQIHKDGNKVKIYSRRLEDVTNALPEIVEAVKNINVDKLIVEGECVAIDKQTGKPRPFQDILRRFRRKYDIGKMMKEINLRVYLFDILYKDGVSFIDEEFEKRRKVLEEIVGYENDWRTERKRIEKELKSDKIIDISYKLVTNDAKEAREFYNWSLSIGHEGVMIKNLKAPYTPGSRVRTMYKFKPTLESLDVVITKAKRGMGKRKDWYGSFEICVRDEEGNLYPIGHVGTGLTEADLEFLKEEIDKIIIRDLGEEVEVEPKIVIEVAYEEIQKSDKYPCGYALRFPRVVRFRFDKGVNEINTIEDVERIYEIQRGRK
The following text describes a protein:
Function:
Transcription activator that binds DNA in a sequence-specific manner, likely 5'-GAAATTTTGG-3', to promote the expression of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MRIPTYDFGSKFSVVQEVMRLQTVKHFLEPVLEPLIRKVVKEEVELALGKHLAGIKWICEKETHPLESRNLQLKFLNNLSLPVFTSARIEGDEGQAIRVGLIDPSTGQIFSSGPASSAKLEVFVVEGDFNSVSDWTDEDIRNNIVREREGKKPLLNGNVFAVLNDGIGVMDEISFTDNSSWTRSRKFRLGVRIVDQFDYVKIREAITESFVVRDHRGELYKKHHPPSLFDEVWRLEKIGKDGAFHRRLNLSNINTVKDFLTHFHLNSSKLRQVLGTGMSSKMWEITLDHARSCVLDSSVHVYQAPGFQKKTAVVFNVVAQVLGLLVDFQYIPAEKLSEIEKAQAEVMVIDALSHLNEVISYDDEVSMMRNVLNAPASQGSVAGIDYSGLSLTSLDGYGFVSSLHNTAECSGKHSDDVDMEVTPHGLYEDYDNLWNCSHILGLEEPQSELQSALDDFMSQKNASVGGKAHSKRWTKLFSVSRWLSVFKYVKLGKI
The following text describes a protein:
Function:
G-beta-like protein involved in cell signal transduction (By similarity).
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MQSTSSTSSGSCSRPLEGSTLNSGGSAENVARDGGSGDDSVGIGDENPSGSSAATNGHDSKHNGFIVNNNGSSSRIVDGENNRENTSCSGVQLDKSNQEIIRLIGQYLHDVGLDKSVQTLMLESGCYLEHPSATKFREHVLMGDWSKADSDLKDLEPLIDNGKLATITEMKFILLEQKYLEHLDDGNPLDALHVLRSELTPLQHNITRVHQLSSYMMCSTNQDLYQRAKWEGKGILSRALVMERLQTFMPPSVMMSPRRLRTLLQQAVELQSQHCPCHDMAWETNLETVSLLTDHCCTTDGFPMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDPYKLTLKHRRVLDGQAQLSVSFVSWSPDSKLILVGGTEDSHELYIWNVDDGKLVVKFSQSLEDSLACGAFSRDGARFVCGGQKGQLYLCDLNGTIVDSWEGVRVNSIAFRADNKTILAADNHYRIRGYNFDSPRSDFDILREPHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQSNFAIHSCFGGVNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIWGPKPNGSSATTESDDCSSSSSSSSWNMT
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MYTTGLIGKNINYSESPEIHNNYYKKNNIPFFYKIFNLKQDQIDDFIKNLHKNNIKGFNVTIPYKETILQYLNDIVYPADKIGAVNTVAVQEDKLIGYNTDYIGFIKSLQYYNIQVKNFKCLIIGSGGSAKCIYYALKELNARDICIVSRNPEKARLKFEKKVKILNIKDENKLDRYDLIVNCTPIGGPNLKEQKPIELKEIKKNCVVYDLNYTPKRSKLLKEAKENGAFIINGEKMLIFQAYSAIGLWCLNGIKGGR
The following text describes a protein:
Function:
Actin-associated protein that may play a role in modulating actin-based shape.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MVKGERLTAVLTGGPPWGFRLSGGLEVKQPLKVAKVRKKSKAHGSGLQEGDEVLAVNGAPCQDVTHKDCMGIVEGSTDRLELEVLRKRPTYNVQQAGQTTEQEESGSKLEIKVNSVAKKDKQHVSTLQIKPVTVSASSVKSESRREVSAITVAKEESSQQSQVVRSTESEYSTLERKSKNVSKVNGLGQVSVFSGSARTEEEESGERKTQGFSYLKPGDIRSLGQSGSPEDKQKRAPPPTAARSSQEYPVNPPPSYSRALNESQYQQAYSPTSGQPGDQPFEEQEPPSSAFRSVRPPGPIKLEPQQGHGINSQPGHLLRQQQQIQEPQPVTATQPAVQRPTPIRQQPATVYQPERQAGSPHTWSAGVPKQEPVPSSQPAIQQPAGSYPFDQPTPSYSQPPASAPTYTWNPTGRSKPKTPITPTTPTEASPNKVFSVFDVGATWEPPKEEETGNMMNAKPKAPMFKVKKFDFKPQTWSEGSSSGRPMTQEDFQTMDLPLGPMGQYRNKQREMLAYEKSGAVWSPSGTTPVSGPKSWSPGGGEVQERPHEVREQPWSPTGRPQAPHVQSPQPAPAVWSPGGGGGQAPRAAQPVSFHPGGGTEDHGPQPTSNGVWRPSQMPPSSQGYYSGERDSGIWSPTGTQATAPSRSFNDTDGHGSPASFDPRPKMVSAQSSSARSAAASLKKPGDLTPAPTGDKQPGPALVATGPVMMNGTVHVNIEWQNEPKSNGYGVRTPATITLEEPLKVSDEEDLYPPEERYKVKICHRLARALLSRHNRFSRGGRMFWKRRLRAHKWEADPFGPAVHPRDATPQEFRPGVDVPDVPEDLYQLVLEEIREGPADDDVDETDLDYPYNSPGAPGRGGKAVGPTRVGPLPSYLNIQEEQTRNASEHFMTVKPTPALTSQEPLKPTLQTLPTRSYLEIQKEAKPEPENAAEKEKKQKQRLHPKSISEYYNLPPEAALPEKDTTKRIPVSEIEPINFNVDLEDKSRCTHQTPEMLSHDAARRLAEATFFEEGKGANMFMKRMERMSKYVIDESNVKKAPPKPQVSPNVPQYQYQKQQQQQQKGTPTVQEMKEMMSQVTYKRPPKSPWEAAMEGSGKIDDAFSHIRGNKLLLDVPPGSQQEYDPFDPTLPFPGSQPTDLGGEGVPSWTSQDGMSMNEKSTSPTGPQFKDYNAKPRGWVSSGGGYLSDQLATDYESDTNLSTASAPSRQQLFKVSKVPTAAGSARQLRPQHLYMGHGQPPQPRPMSPMRPLTPQRPTTPPYWPSSRSSTPTPYWQRKATPPEVAPRSQSRSPGPGTASTSSWRWTIPRSEATPKKKSPTKAPTPFTVAAFQPSPSPRATSPVDVSWRRTMSLTAGTPDYGVPPERSPTHFTQASFLHSRQQVPMEKLGKGAKMFQKQKERSEKFVIDENTVARTPIRRAERERSSSSSSSSHVSKARLTPWEAAATMGTVDPAFSSIDVEMKVHGSPYKARVAHTVMDAAGSKAMPSPPAEWKRTQMNGQQWSPTVASYVTKPRFDARQMSMSPTIQPARVTPFAFTYNPSIKAWSPQHGMRGAEE
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Plasmid targeted by CRISPR locus P1 transform wild-type cells very poorly. This protein helps process or stabilize pre-crRNA into individual crRNA units, in vivo Cas5 and Cas6 are also required for optimal crRNA processing and/or stability.
Miscellaneous:
MISCELLANEOUS: There are 3 CRISPR RNA loci in this organism and a single cas gene locus. A CRISPR-Cas type I-B system.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPHIDANGVPIDCLSFTVRSTWGHFKRVGRSVTKQTYRIPPRTTVAGMLAAIVGADRDSYYDVFGADNSAIAITPLSDLRTVNIPTTGLGTDPKQDVTETAGSWRTYKLTYQNTTGDRQLHSYEVLADPAYRIDVALENEEFYDSLREHLVNGTSIYPPSLGKSEYLAVIEDVEVDREPEVQDIDETLDIDSVVPISLSEAVPQGKVTYGVERSPAVMVRESGGRRTTRFDDYVYAQQASNPVRIGEQTDVAPVQVGDRTVVFR
The following text describes a protein:
Function:
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPRKVSELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKIPPATHKTKSEDNIKEEKTDSKKAEENIKTDEPSSEESDLEIDNEGVIEPDTDAPQEMGDENVEITEEMMDQANDKKVAAIDALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFIKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKEVQPRAQKIAEHRRKYERKREEREIKERIERVKKAWEEHERAQREEEARRQSGAQYGSFPGGFPGGMPSNFPGGMPGMAGGMPGMAGMPGLNEILSDPEVPAAMQDPEVMVAFQDVAQNPANMTKYQSNPKVMNLISKLSAKFGGQA
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MHLESIVLRNFRNYENLELEFSPSVNVFLGENAQGKTNLLEAVLMLALAKSHRTTNDKDFIMWEKEEAKMEGRIAKHGQSVPLELAITQKGKRAKVNHLEQKKLSQYVGNLNVVIFAPEDLSLVKGAPGIRRRFLNMEIGQMQPIYLHNLSEYQRILQQRNQYLKMLQMKRKVDPILLDILTEQFADVAINLTKRRADFIQKLEAYAAPIHHQISRGLETLKIEYKASITLNGDDPEVWKADLLQKMESIKQREIDRGVTLIGPHRDDSLFYINGQNVQDFGSQGQQRTTALSIKLAEIDLIHEETGEYPVLLLDDVLSELDDYRQSHLLGAIEGKVQTFVTTTSTSGIDHETLKQATTFYVEKGTVKKS
The following text describes a protein:
Function:
Non-essential E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (By similarity). Accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the proteasome. Elongation of ubiquitin chains on substrates bound to the proteasome promotes proteasomal processivity. Also promotes ubiquitin elongation of 26S proteasome subunit RPN10. Involved in the stress response required to maintain cell fitness following heat-shock: acts by mediating ubiquitination of cytosolic misfolded proteins, leading to their subsequent degradation.
Miscellaneous:
MISCELLANEOUS: Present with 3120 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MLNFTGQTRRRNVNLGNRTRNSKKDLLEKAKRERERRAQDKLKEDASKTIQKSIRRHFSNVRLFKNTFTSSQLVHMIPAYGGKLIYYISQYDLQQLLKLSHNFLSSYPNSLGNRQLLSLLKLYQDDALVAETLSDLNMDCPTVDEFLDSLSVYLCRASFLSYSSASKLADVIEAWEVMHSSASISIFSISIGSYEKRPFALQFYCILAERNLLPQLINTNPILWDNMAKTYSHCSKGGQKNIAKLLIPNFNNHIAPSVLRSDNDYVLKFYEKAFIDEVIATTANYVSDEDHVKNLMCYIASSPNQSCKNSVLITLLSNKDFVRRLSWEFFHTKFNASKTEAHPLFSVLAQLIDMHLLISTDRELLDYNSVIPIEELKKFTSTLKDFTFRQYWELPKSERNPMLKEAVPLLSKVYERDSRLHFLSTENNPTYWENSEKQFLNLRFYEELQEYEDLYREHLEEESDEDMEKEIDLDKERPPLKSLLLNKMKKRLKSSLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRKQSAIISRDNVLEDAFNAFNSIGERFKASLDVTFINEFGEEAGIDGGGITKEFLTTVSDEGFKDPKHELFRTNDRYELYPSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDLS
The following text describes a protein:
Function:
Unknown; dispensable for production of the lantibiotic sublancin 168 and for competence for DNA uptake.
Subcellular Localization:
Secreted.
Sequence:
MKKWIVLFLVLIAAAISIFVYVSTGSEKPFYNDINLTQYQKEVDSKKPKFIYVYETSCPPCQEIKPELNEVIKKEKLKVQALNIEEKENYNTEFLDKYNLNKTPTILYYKDGKEKDRLEGYRSASQIEKFFDKNGDR
The following text describes a protein:
Function:
Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33.
Subcellular Localization:
Nucleus. Cell junction, adherens junction. Cell projection, dendrite. Perikaryon.
Sequence:
MFARKQSGAAPFGAMPVPDQPPSASEKNSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSISSAGEQFHWQTQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTSERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGDTAPSQLPARSTQARAAGQSFSQGTTGRAGHLAGSEPAPPPPPPREPFAPSLGSAFHLPDAPPAAAALYYSSSTLPAPPRGGSPLTTTQGGSPTKLQRGGSAPEGAAYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLAPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTFRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCASVDSPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGETNGKDTESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKGWAEDVAGMAYALRSLPEGAPCLPQWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNSGSKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYESAGNNATYHGTKGEHTSRKDTMTAQNTGVSTLYRNSYGAPAEDIKQNQVSTQPVPQEPSRKDYETYQPFPNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MDAVNIEQIDQEITLNLQSIDSDLSYCFNKITKDIIPYVTRYGQTCEDITNSSSWLKEMFQQSANVQLVTDQAVESAGQVLEPRTSLFPEVENETDEFHTVDQYPALSQTGVSSAGAPTTKTGGSVKQDQFQDQDTDELTQDSAMEKQRKKRKVSLQIHQHFNSSSSSNSSMENDISANSSPIKTIPPETETGTETHNKIQGELAKPGTVIHFNSKRD
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MLCDNFPGAVFPGCYWGSYGYPLGYSVGCGYGSTYSPVGYGFGYGYNGCGAFGYRRYSPFALY
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
The KA1 domain mediates binding to phospholipids and targeting to membranes.
Sequence:
MPVDSTSELLKHYEVYETIGSGGFAKVKLGRHKLTGEKVAIKIMEKKDLGDDLPRVKIEIEAMKNLSHQHVCRLYHVIETTSKIYMVLEYCPGGELFDYIIAKDRLSEEETRVFFRQIISALAYVHSQGYAHRDLKPENLLIDEDHNLKLIDFGLCAKPKGGLGFELLTCCGSPAYAAPELIQGKAYIGSEADVWSMGVLLYALLCGFLPFDDDNCMVLYRKITRGKYSNPHWLSPSSILLLNQMMQVDPKRRLTVKHLLDHPWVMRGYSTPVEWHSKYPLGHIDEDCITEMAVTFKQSKQRTIQLVSEWKYDQITATYLLLLAKKRQGRPVRLRAECPVIDIVCSPLQDMQLKKSLRFTEDDDGVHPVVLGSMVFPPDCYDDENPWTPLTPKNTHTTNTPRMKLYPETTEKWNEMAYSPVIEHSRPCRQKPERRERTKENKENLAVPGTDGDVFALPAPRTPTSSRKVKSNRTVMTTPNHNNNKSSEVNKGAGSATKEGSRRREVEQQQNGQQGELNILAFSPERRSRSLDLAGCQVDSGQKRKGGKVFGSLERGLDKVITMLTPSKKRGPRDGPRKIKAQYNVTLTNQTNADQVLNQILSILPEKNVDFVQKGYTLKCHTQSDFGKVTMQFELEVCLLQKPEVVGIRRQRLKGDAWVYKHLVEDILSSSSQWSA
The following text describes a protein:
Function:
Able to directly activate the TNF-NFkappaB signaling pathway.
Sequence:
MVVFLSKNVRSLLSIFKKKGQKQDEQRKLTVHYTASQHYQENVFIEGSRPKYLEDLHTEAQEGLKILQQEEEDTSSKERNESLENDSTSGHSIISVSTASAVSTRPVLTRQGSTFKPLNPVKRLDKSKRRSRRTTIMGIPQQVQRELDMARGTMLQQLPNRGHDSEDDSSGTVVLQTIDGDLPSVNHEGARVHLQNIEVLQASRDEDLLLNHIHSVYQDELNRKLGLGACPTQRPKSLAVPGMTTYSFLQEPQGPVMSISPQATYLSKIIPNAVLPAAIDIIEINHDHNRCSASTASKGSMASASPSSSRSGSGTNQAPPTTSPSRSNSQSSETIVSNSSTISSKGKCLPTFDADSAKDISVLIPKDMSVSSSSSWKSSEGKGTNHRLNPREYGDAGDNVRNSHSFSRSLSVMKTKLPPAPPQRTYSLHHENMQRQREQGDIQDPKDVAPNNNEQTNRDISSTKENHQSAKNKKSSVHSLELRSDFHTTVKSSPLSPDQVFTGRHARSGNSSPQKTRECGENFDRTLSPSSGYSSQSGTPTHSPKEVSPSSPGKRRVKPSKPERVCAKTSPVVSVSSSLTSLSSVISDTAHQDIQTNTTSSEPLKFSPPLTTVKNKVTPTHQTIALRTLFNIPPPPKVKAPSPPPPETWVQNKQTLELLCGPGPNIHKLESLISKTQNKNSMQINEQVIPKTQTTEETKTENTVVKELTKSASPQVHKQMMVEPPDVRHTEKSILHNELKSPETLAKVNQIPHTQDEKTIEDQKDRWSQTLPTTNVPSIIVDQSMLSQTNSIEKTKAATVSSNENQRNCIVTDIVNRISVQTLNIEVPEVNGVSPPPSPPPEHHPPPPPIKKMSDMSVSIPPSEKEEQKQVEQVTFPESSWPPPPPPMEESTELMFEEQDELDFPPPPPSFIHEPMSEISDDFHEESCEEVSIKLLSTNVSDMDSSPEQDSERHTILPKRIVQNSVEVRQQDKSSDSVSEFLEDQAEIENTNVASTIISSHLPDKNLHEKETLVSTSIPLAPPLPVEEQSTINFRKQLSFVDKDNRSKELLCRHKSTPIPKEDANIPLVTPSLLQMVRLRSVNVGEDQVNNDSKPSTEPTTNEDHSISSQVTPQKPIRRSLTLKSNSPAKSSSASSAVPSMCLQEAIRMKTAAMSCSGVPAMLNLRSSSGSSATSPVPSPKSPDGCDLLMSPASTASFIFSKSTKRVVIETPTSPDVQASLKQSLAAEIMQVSDQAKTMITNGTKKPIKVPPPVAKKPVHGSNPPNKMENATQDKTEILTNKQIMRVDVNGQSDQVHPAGQRAQSLGNQEQASKEAFAMNMSICA
The following text describes a protein:
Function:
Repressor of strigolactones (SL) signaling. Subjected to a negative feedback control of SL signaling. Suppresses the transcriptional activation activity of SPL14/IPA1 in SL signaling. Acts with SPL14/IPA1 to mediate the SL-regulated tiller development. Subject to a negative feedback regulation by SPL14/IPA1, which binds to D53 promoter to repress D53 gene expression.
Subcellular Localization:
Nucleus.
Domain:
Contains 3 EAR motifs associated with active repression of several target genes. The D1 domain (195-440) is essential for the strigolactone-dependent D53-D14 interaction.
Sequence:
MPTPVAAARQCLSPAAVPALDAAVASSRRRAHAQTTSLHLISSLLAPPAPPLLRDALARARSAAYSPRVQLKALDLCFAVSLDRLPSVSASSSSSGAADEPPVSNSLMAAIKRSQANQRRNPDTFHFYHQAATAQTPAAVKVELSHLVLAILDDPVVSRVFAEAGFRSGDIKLAILRPAPPMPLLGRLPTRTRPPPLFLCSFAAADDADVPSPAGNLAGAGEENCRRIAEILSRGRNPMLVGVGAASAADDFAAASPYRIIHVDPNTIDRSDLGVAAAMASATSGLIISIGDLKQLVPDEDAEAQEKGRRVVAEVTRVLETHSKVGRVWVMGWSATYETYLAFLSKFPLVDKDWDLQLLPITAVHAAATAGPAAAAAGLMPPATTVAAFSKPAASLMDSFVPFGGFLCDNYEENSLTANSCPQALRCQQCNDKYEQEVATIISASGITAEDHHQGGLPSLLQNGSMMGPNNGFDPVKARDDRMVLNSKILNLRKKWNEYCLRLHQDHQRINRDPYKPFPRYIGVPTDKERSANSSKGSESVGVQKDVIKPCAVSAVHSSSTARPISSPSVTNKRNEDLVLNLQARHSKSDENLQERGMQSQHGTLSNVDNPDDHVSPSSAAPVETDLVLGTPRECSSKGSSSTCSKRVEDSERSVHLVPKKVDDLNLKHPQLSVQPNSCSWSSINVGKTSHSTLHSVASGGFSAFGQWQKRSPLAAQNSDLSNYKLLVERLFKVVGRQEEALSAICESIVRCRSTESRRGPNRNDIWLCFHGSDSMAKKRIAVALAELMHGSKDNLIYLDLNLQDWDDSSFRGKTGIDCIVEQLSKKRQSVLFLDNIDRADCLVQDSLSDAIKSGRFQDMRGKVVDINDSIVVLSRSMIQGSKNGLEEGLSFSEEKILATRGHRLKILVEPGRAITSGCPSGKVVVSPRHFLTKIQASLCSGSISKRKLSISDDQEKLQESPSSSKRLHRTSSVPFDLNLPVDEDEPLDADDDSSSHENSYGNTEKSIDALLHSVDGSINFKPFDFDKLADDMLQEFSNILRKNLGSECMLEIDVGAMEQILAAAWKSEEDRKPVPTWLEQVFARSLDELKLKRKHVSSSTLRLVACEDTVPAVKGDGLGVLLPPRIILDC
The following text describes a protein:
Function:
Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites. May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex.
Subcellular Localization:
Late endosome.
Sequence:
MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGQLTNLELDEEVLQNVLELPTWLAITRVYCNRASIRIQWTKLKTHPICLCLDKVEVEMKTCEDPRPPNGQSPIALASGQSEYGFAEKVVEGMFIIVNSITIKIHSKAFHASFELWQLQGYSVNPNWQQSDLRLTRITDPCRGEVLTFKEITWQTLRIEADATDNGDQDPVTTPLRLITNQGRIQIALKRRTKDCNVISSKLMFLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAHQRKSLAPEPVQITPPAPSAQQSWAQAFGGSQGNSNSSSSRLSQYFEKFDVKESSYHLLISRLDLHICDDSQSREPGVSANRLMGGAMQLTFRKMAFDYYPFHWAGDSCKHWVRHCEAMETRGQWAQKLVMEFQSKMEKWHEETGLKPPWHLGVDSLFRRKADSLSSPRKNPLERSPSQGRQPAFQPPAWNRLRSSCMVVRVDDLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPTQVSAIHIEFTEYYFPDNQELPVPCPNLYIQLNGLTFTMDPVSLLWGNLFCLDLYRSLEQFKAIYKLEDSSQKDEHLDIRLDAFWLKVSFPLEKRERAELHRPQALVFSASGMIATNTRHAPHCSCSDLQSLFRGFAAAEFFHSNYDHFPKVPGGFSLLHMLFLHHAFQMDSCLPQPNTLPPQRPKASWDLWSVHFTQISLDFEGTENFKGHTLNFVAPFPLSIWACLPLRWQQAQARKLLLASEGRLKPSASFGSPVQSEALAPDSMSHPRSKTEHDLKSLSGLTEVMEILKEGSSGMDNKGPLTELEDVADVHMLVHSPAHVRVRLDHYQYLALLRLKEVLQRLQEQLTKDTESMTGSPLQNQTACIGVLFPSAEVALLMHPAPGAVDADSAGSDSTSLVDSELSPSEDRELKSDASSDQGPASPEKVLEESSIENQDVSQERPHSNGELQDSGPLAQQLAGKGHEAVESLQAKKLSRTQASSSPAALKPPAGRETAVNGQGELIPLKNIEGELSSAIHMTKDATKEALHATMDLTKEAVSLTKDAFSLGRDRMTSTMHKMLSLPPAKEPMAKTDEGVAAPVSGGAARLRFFSMKRTVSQQSFDGVSLDSSGPEDRISVDSDGSDSFVMLLESESGPESVPPGSLSNVSDNAGVQGSPLVNNYGQGSPAANSSVSPSGEDLIFHPVSVLVLKVNEVSFGIEVRGEDLTVALQAEELTLQQLGTVGLWQFLHGQCPGTCFQESSTLKTGHIRPAVGLRFEVGPGAAVHSPLASQNGFLHLLLHGCDLELLTSVLSGLGPFLEDEEIPVVVPMQIELLNSSITLKDDIPPIYPTSPGPIPITLAMEHVVLKRSDDGVFHIGAAAQDKPSAEVLKSEKRQPPKEQVFLVPTGEVFEQQVKELPILQKELIETKQALANANQDKEKLLQEIRKYNPFFEL
The following text describes a protein:
Function:
Ca(2+)-regulated actin-binding protein. Involved in actin filaments bundling. Caps the barbed end of actin filaments and is able to sever them in a calcium-dependent manner. Required for the construction of actin collars in pollen tubes. Acts redundantly with VLN5 (AC Q9LVC6) to generate thick actin filament bundles and to regulate polarized pollen tube growth. Acts redundantly with VLN3 (AC O81645) to regulate directional organ growth and in sclerenchyma development.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Present in the apical and subapical regions of pollen tubes.
Sequence:
MSTKVLDPAFQGAGQKPGTEIWRIENFEAVPVPKSEHGKFYMGDTYIVLQTTQNKGGAYLFDIHFWIGKDTSQDEAGTAAVKTVELDAVLGGRAVQHREIQGHESDKFLSYFKPCIIPLEGGVASGFKTVEEEVFETRLYTCKGKRAIRLKQVPFARSSLNHDDVFILDTEEKIYQFNGANSNIQERAKALEVVQYLKDKYHEGTCDVAIVDDGKLDTESDSGAFWVLFGGFAPIGRKVANDDDIVPESTPPKLYCITDGKMEPIDGDLSKSMLENTKCYLLDCGAEIYIWVGRVTQVDERKAASQSAEEFLASENRPKATHVTRVIQGYESHSFKSNFDSWPSGSATPGNEEGRGKVAALLKQQGVGLKGIAKSAPVNEDIPPLLESGGKLEVWYVNGKVKTPLPKEDIGKLYSGDCYLVLYTYHSGERKDEYFLSCWFGKKSIPEDQDTAIRLANTMSNSLKGRPVQGRIYEGKEPPQFVALFQPMVVLKGGLSSGYKSSMGESESTDETYTPESIALVQVSGTGVHNNKAVQVETVATSLNSYECFLLQSGTSMFLWHGNQSTHEQLELATKVAEFLKPGITLKHAKEGTESSTFWFALGGKQNFTSKKASSETIRDPHLFSFAFNRGKFQVEEIYNFAQDDLLTEDIYFLDTHAEVFVWVGQCVEPKEKQTVFEIGQKYIDLAGSLEGLHPKVPIYKINEGNEPCFFTTYFSWDATKAIVQGNSFQKKASLLFGTHHVVEDKSNGGNQGLRQRAEALAALNSAFNSSSNRPAYSSQDRLNESHDGPRQRAEALAALSSAFNSSSSSTKSPPPPRPVGTSQASQRAAAVAALSQVLVAENKKSPDTSPTRRSTSSNPADDIPLTEAKDEEEASEVAGLEAKEEEEVSPAADETEAKQETEEQGDSEIQPSGATFTYEQLRAKSENPVTGIDFKRREAYLSEEEFQSVFGIEKEAFNNLPRWKQDLLKKKFDLF
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSSYFVNPLFSKYKGSESLEPTYYDCRFPQSVSRSHALVYGPSATAPGFQHPSHHVQEFFHHGTSSITNSGYQQNPCALTCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSSNTNTSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGAREEEKTEEGEEGNEEEEKEEEETKESKE
The following text describes a protein:
Function:
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MMTAEHGEPCEESEASYCFNGGLCYRILSISTPSCVCQENYKGSRCEQFQLPSSSIDASEKGMLAAVVILLLLILVALAAVIYCSWKIRRRKEESRTARSDGLINANRV
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MAKAKEEDELTMLEKGIEELCTQIETTYCRQSLEKTSGPRNKCYKYITSLKDNWSKKLAEGDEIIRKVHQYTNECCQKNKLAEEKQQKLSEILAIIEDEKKQEKELKKNIQALKEELIRKNKISAENKATEEVTEKLRNAENLFKEGLGLEIRRTSENQLQFIFRCISRKDFDEPYTLTLSLNEEGTYEGMCKLPKQNLNISRWKSSGQLFLDSYFFPASMPKL