lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Sequence:
MSFMRKKGRKWDDQTPRVRPKCLEAAREVAKKINSRLIAEGFLKLPEENSARSAAEVHNMNDPAAQALPTLGGSRGLLVGTTSHDQQCTVEIDINEIPLACRNLLTRSVTQEDISKMSGAKVSTKGRFMTSTEKMMSKLTGEKALHLCVQGAVASSVELAVQRITSIISSTCNIPPTSLSIMSQNMPLSTTSKPLLMPGPPSSLNFTPQTLAFVQDKLFIGLEQAPPTFDIKTKLLGPNGTYLHHIQSETGAKVLLRGRGSGFNEPTSGREAFEPMHIYIQHSNHVGLNQARTLAQNLLQTVQHEYATFQQQLAFMPPSVLPATASMLAGLQQQQQNFTGRNAVDKEIMPPPMMTNLKTLSSKRLKSSASGWKSVECWSWRMHIAWWWGILGSQGNQHELLLIRSGEHRPMIDYILVRDKHRKYVKNVKAIPDGKSSKDTNSSKGNTKISFSLADSPAVKPKKLEGALGGIVAYGSDSEEDSET
The following text describes a protein:
Function:
Esterase that catalyzes the deacetylation of acetyl-(R)-mandelate (in vitro). Can also hydrolyze acetyl glycolate, but with lower efficiency. Has very low N-acetyl-D-amino acid deacetylase activity with N-acetyl-D-serine and N-acetyl-D-threonine (in vitro). Theoretical substrate docking studies suggest that other N-acetylated amino acids may optimally occupy the active site and may in fact be the physiological substrates.
Sequence:
MISGEQAKPLLITNVKPVAFGVEHSDATTDILVGKDGSISAIGKSLNAPADVERVDGKGAWISPGWVDLHVHIWHGGTDISIRPSECGAERGVTTLVDAGSAGEANFHGFREYIIEPSKERIKAFLNLGSIGLVACNRVPELRDIKDIDLDRILECYAANSEHIVGIKVRASHVITGSWGVTPVKLGKKIAKILKVPMMVHVGEPPALYDEVLEILGPGDVVTHCFNGKSGSSIMEDEDLFNLAERCSGEGIRLDIGHGGASFSFKVAEAAIERGLLPFSISTDLHGHSMNFPVWDLATTMSKLLSVNMPFENVIEAVTHNPASVIKLSMENRLSVGQRADFTIFDLVDADLEATDSNGDVSRLNRLFEPRYAVIGAEAITASRYIPRARKLVRHSHGYSWR
The following text describes a protein:
Function:
Putative sodium-dependent amino acid/proton antiporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRAGPRRQHLLPPQDNRAAMGYQRQDPVIPPQRDLDDRETLVSEHEYKEKTCQSAALFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLILLIKGGALSGTDTYQSLVNKTFGFPGYILLSVLQFLYPFIAMISYNIIAGDTLSKVFQRIPGVDPENVFIGRHFIIGLSTVTFTLPLSLYRNIAKLGKVSLISTGLTTLILGIVMARAISLGPHIPKTEDAWVFAKPNAIQAVGVMSFAFICHHNSFLVYSSLEEPTVAKWSRLIHMSIVISVFICIFFATCGYLTFTGFTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPMECFVTREVIANVFFGGNLSSVFHIVVTVMVITVATLVSLLIDCLGIVLELNGVLCATPLIFIIPSACYLKLSEEPRTHSDKIMSYVMLPIGAAVMVFGFVMAITNPQDCTHGQEMFYCFPDNFSLTNTSESHIQQTTQLSILNISIFQ
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEKGVEHLISARKSMRVNLEKSKDIGLSLEKARPRLVEISQRLPSLEAAIRPIRADQDALGAVVGHINRAVVPAAAVLKVFDAIHGLENSLSDPESDLPGYFGVLKRLKEALKFLGENCDMAIQWLADIVEYLEDHNVADDKFISSLKEALTTLKELHRGEDWSCLDGGLLEAALDRLENEFRRLLTENSVPLPMSTPDLPGEQACIAPSLLPVAVIKKLQSILGRLVANNRLEKCVSIYVEVRSSNVRESLQALNLDYLEISVSEFNDVQSIEGHIANWGKHLEFAVKHLLEAEYKLCNDVFDRFGLDVWMGCFAKIASQASILAFIQFGKTVTESKKDPIKMLKLLDIFASLNKLRLDFNRLFGGAACAEIQRLTRDLIKRVIDGASELFWELQVQVELQRQIPPPPDGGVPKLIIFITDYCNKLLGDDYKPMLTQVLVIERSWKREIFQERLLFDELLNIMRAVQLNLETWSKGYKDDTLSYVFLMNNHWHLYKDLKGTKLGILLGDSWLREHEQYKEYYSAVFLRESWAKLPALLSREGLILFSGGRATARDLVKKRLKAFNEAFDDMYKKQSNWIMLDKELREKTCQLIIQAIVPVYRSYMQNYGPLVEQEGSSKYAKYTVQSLEKMLNSLFVPKATRQGSFKVRVPSGKFNNSVADQNQTAIVK
The following text describes a protein:
Function:
Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTDTQSNVPQSQIQPQVPTIGVVRAVNSGDSLVIQDLKTADSPKVEYSLSHLTVPRLGYHGSNDKPPTKDLPFAWESREFLRSKCIGKKVQFFTDYTAPTGKKFISVYLYDDLENSLNKQMIEEGWASLYRSTTGKENKKPEYLNLIQLESEAISKELGIHNKNPIAITNSIRPIHTINSFDLFNKLKGKQLTAVVEQVRNAASYRVTITPSFHTFLIQLSGVQCPGYKKDNNNQMQPEPFALEAESFISKNLLHRDVQLTLDTFDKQGNLFGTIKCADRDVACELLKNGLGTYVPWSGATRSAPDQMLLKQAEETAKGQGIRVWYQSPSSSSTSSSSSSSSSSNEPYPKEIDGKVIDIGNNGTVGILSENDRKEYKVTLASIRVPNFTKPSEKEDKDSKFERYYAYEAKEWLRKRLIGQKVIAKLEFIRPAIASSNLPEKPYYSVFLGKGNVSLGLVEAGLARLTEHKGADNRAIDYEALITAENKAKKKHSGLYSNKDSAPSFNVNDVSSEDKNLKAKAQKLLPHIRGIVLPAVVDYVFSAQRVKLFIEKESCMINFTMSGVRAPRRDENEELSNQALGFSREHLHQHDVHIQIEDIDKGGNFIGTLMVGNKNFALSLVEMGFASIYDPMNRLNDYQRFEDAENKAKSSRLNLWKNYDPEEEQRVANQKAAAEEERKQQQKAETGEAYIRAVVSPTEVYLQFANNKTKDIESQLASLEINNEDSTIVAMPKVGDIVKFKSQHDKKWHRSKITSIADGKINVNLIDLGERESFPQSQSSTLIRNINHKLQSLPSLVTLVKLASCKNPSNDDIYNDAMDFMEKEFLDLKVGVNIIRDIDGTQHVLLSDNAGIINGELVRNGLVSVDRSTKLPSIQQLQDEEQKAKSKRLGVWRFGDIDSDDEDDKPRSNFKGKGGKPISKK
The following text describes a protein:
Function:
Required for gamma-tubulin complex recruitment to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
Sequence:
MASNAASLNAVRETMDVLFEISRILNTGLDMETLSICVRLCEQGINPEALSSVIKELRKATEALKAAENMTG
The following text describes a protein:
Function:
May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MEAPYSMTAHYDEFQEVKYVSRCGTGGARGTSLPPGFPRGSGRSASGSRSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGGGGACPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRDVSSAYNKVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSSWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW
The following text describes a protein:
Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
KQGNWEGCYKESIVFSPGASRNVGVCFGSNSSWSYQLMPGDSNGKYWNSTEDYLTFFCGPRRSHLFLPMTVVYGLIFLVGVTGNLLVCLVILKHQTMKTPTNYYLFSLAISDLLVLLFGMPLEIYEMWYNYPFLFGPVGCNFKTCTTVSVERYVAILYPFRAKLESTRHRALRILVILWIFSILFSLPNTGIHGIKVYHFPNGTLIPESATCTVVRPMWIYNFIIQVTSFLFYVLPMAVMSILYYLMGLRLRGDQSLEAEEMAANVQRPSRKSVTKMLFILVLVFAICWTPFHVDRLFFSFVEEWTESLASVFNLVHVISGVFFYLSSAVNPIIYNLLSHRFREAFLNVISPLCKHWHPKHSPSVPPAHKDTFLPGECHRKSELFGSLKRTATQYKIIGTERSC
The following text describes a protein:
Function:
Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in progression through the cell cycle (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasm.
Sequence:
MGSSLSEPCIYDKLSESIDILRQSGYRYGMSEREIEKFIKQVLETNEPRREPPQFPILRATVKFVVAVGVVLMAVLVFTYPQSPVLMGSVSGTTLNNSSPLSHIRLLELPIAEKYNLHGFHEWWASSSLQTMDLNCSACTDVTDILELTDQLRTSAGEHTRTQPLLLKGGAALSLRVSQMDQFSSVSQTPANFTLLWSVSSRPRESVLQWLFPESERCPLLEIWSSTLQRCRLSSRRPQPSRVQVLGWMVVADGSPDVRLLPVQRCRKHCRSFSLRLEPGDMVFADSQIWLMELSPSGAQDVQCDSAVL
The following text describes a protein:
Function:
Involved in resistance to abiotic stress.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cytoplasm.
Sequence:
MSDPKYAYPYPAPGNYPQGPPPPVGVPPQYYPPPPPPPPPPPPPRKVGFLEGLLAALCCCCLVDECCCDPTIICFD
The following text describes a protein:
Function:
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Sequence:
MRSDTIKKGVERTPHRALIKGTGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKGIHSGGGYAFFFGIPGVCDGISMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLNIPSIVVTAGPMMAGRGTEGRRYSFVTDTFEAMARYKAGVIDERELGVCEDNACPGMGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVDLVRNDITPRQILTRDAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDTLAKETPQISSMNPAGEYFMEDLDAGGGVMGVLRQLGSLVRDNPTVMGLSTLQLASTVESVDERVIRPLSNPVKKEGGIAVLFGNLAPKGAVVKQSGVSDAMMTFEGTARCFDSEEAAMAALMGGRIVAGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALITDGRFSGGTRGPCIGHISPEAAEGGPIALVEEGDRILLDIPNRRLELLVDEAVLQERRARWTAPEPKIKTGWLARYAKVVTSAYTGAVTSAD
The following text describes a protein:
Function:
Regulatory subunit of phosphatase let-92 which recruits let-92/paa-1 complex to the centrosomes, thereby regulating microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MPTDEPSKRKSILPTIPTSLMLKKSNEALSDFERTFNDRVMDIFAENRRIDVEEFKKNAECFLNIIRSNKIDLNWGEGGESRYVTITRLMKILKTSPQSIKDLLPHNTVSNFVKITNYNLTIDITLLEELVRTVIHAEESYIKLLPFSENSTEISSYSLQDFVATHFIPIMIEEPENPVYYTAYAVGTIFFLLGARRRDCVYLKDLLASTLLLQLEECIHAENHCLSPPKIDVFTVAQFRTTLSEFRFLDSQRKGLLAPADLKFFRDGIFNEVFTKRIFEISITYEDGRIDFKAFVDFVTALKFRHTTASAKYHFEILDLKDDGLLDEEEIRSISSFQLQNLPDYVPEDNSVNPEVATAELRDMMRLNQNGITLEEFLANRMNSTFAGFLSNSDDYMKYERREQ
The following text describes a protein:
Function:
Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres.
Subcellular Localization:
Chromosome, telomere. Cytoplasm. Nucleus, Cajal body. Nucleus, PML body.
Sequence:
MLSSFPVLLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKPEVLHALETLDRLDQEHSDKFGRRAGYAGGPYASSAGGVPASSSTATAATQTRPSGMSPSPSNSYDTSPQPCTTNQNGREGAERLAASNGKLSPPRYHGNSLGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRPAPIPVEDPEWRQTPPPVTATSGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIEAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDDSTSHSDHQDPISLAVEMAAVNHTILALARQGAGEIKTEALDDD
The following text describes a protein:
Function:
Adenosyltransferase that catalyzes the conversion of cob(II)alamin to adenosylcob(III)alamin (AdoCbl) in the presence of ATP and an electron donor. Acts as an accessory protein of IcmF that functions in cofactor repair, since IcmF is prone to inactivation during catalytic turnover due to the occasional loss of the 5'-deoxyadenosine moiety and formation of the inactive cob(II)alamin cofactor in its active site. Thus, receives and repairs the inactive cofactor, which is then reloaded onto IcmF in a GTPase-gated step.
Sequence:
MGNRLSKIATRTGDAGTTGLGDGSRVGKNSLRIVAIGDVDELNSHIGLLLTEPDLPEDVRAALLHIQHDLFDLGGELSIPGYTLLKAPQVAQLDDWLAHYNAALPRLAEFILPGGSRPAAQAHICRTVCRRAERALVELGAAEALNEAPRQYLNRLSDLLFVLARVLNRAGGGSDVLWQRERES
The following text describes a protein:
Function:
Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLVPYMYYEKQEAGSQLCAQHCLNNLLQQYTYSEFDLADIAKRLDQAENATLDVNHQLRKSYNYDDTGYFSISVLERALEVWDLTMVRWRGEAMKPYQDHPEDQAAFILNLASHWFTLRRFAPNPPHAAASKRWYNLNSFLADGPEWISPTYLHMVLTQAEQEGYSVFVIRKATPGTKEGEEAGEAEGWGDGGIGQLPESLGDVMAVELGEPVGRSGGLLSGTIGPTKESKTTQMSIPADPNTTTVDAEPSSPSRPPRRRRQPDLSSDPTEIVDDPYARPAPSRSRQSSSRSNPAQHQVIGDDEGDIFDQTHGIPSHYDETPDDDNADDDFEMSRSRAYAGTMDFQFQSRSYDDEDEALQAALKASMADLPEGWEMPDILKPESERQAFTTTTSIMTTTTTTPPVAPEAQREESPVATSVAEEKDIVESNEVEDDSDDVQPAEEPSPEEIRRRRLARFG
The following text describes a protein:
Function:
Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression.
Subcellular Localization:
Cytoplasm. Note=In the spermatid, localizes to the actin-based individualization complex.
Domain:
The Hydrophobic-Tyrosine-X (HbYX) motif is involved in proteasome activation.
Sequence:
MESGSTAKTGDFFYGWDLLYKTVKADVSKKSDLLIALVHFLLTKHYNFRCVGVGDDKTLPEEEGSELLPDSWNDDDTKYSLRYVHDKMLYLLLGHITEGSLLINLLDINTKKVSNICVEPETLVPEVKGGITTIMPSASEIVERYRRELLDPVFTGNSREVTTQTTNSPRPIGSDPDPLRIGEPRRGGSFIPSAFEPRPFGFPDVGRGDLDPLGRGGHGNLFSFPSRPNMGPGPVPRFDPFNPLNPNRPGQGGINPDHMRPPDWNPDYYM
The following text describes a protein:
Function:
Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that mediates mating pheromone signal transduction. Binding of alpha-factor or a-factor to its cognate transmembrane receptor STE2 and STE3, respectively, allows the receptor to serve as a guanine nucleotide exchange factor (GEF) on GPA1. The exchange of GDP for GTP on the G protein alpha subunit alters its interaction with the G protein beta subunit STE4, leading to dissociation of the G protein beta-gamma dimer STE4-STE18. The dissociated subunits activate downstream effectors to activate the mating response pathway and induce changes necessary to produce mating-competent cells. STE4-STE18 activate the downstream pheromone signaling MAP kinase cascade leading to expression of mating-specific genes, inducing cell cycle arrest in G1, promoting polarized cell growth to form mating projections (shmoos), and establishing the changes in plasma membrane, cell wall and nuclear envelope to permit cell-cell fusion (plasmogamy) and fusion of the two haploid nuclei (karyogamy). GPA1 transmits a signal that requires direct binding to the effector enzyme PI3K located at the endosome, promoting increased PI3 production. The intrinsic GTPase activity of GPA1 determines the duration of signaling, and is dramatically accelerated by the RGS protein SST2. In unstimulated cells, GDP-bound GPA1 sequesters the G protein beta-gamma subunit STE4-STE18, preventing it from activating the downstream effectors. Also down-regulates the signal by inhibiting the pheromone-induced accumulation of FUS3 in the nucleus.
Miscellaneous:
MISCELLANEOUS: Present with 9920 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Localizes predominantly to the plasma membrane in its inactive, GDP-bound form, and is directed to endosomes once in its active, GTP-bound form. Concentrates at the tip of the mating projections.
Domain:
Contains an 'insertion' sequence of 109 residues which is not present in other G-protein alpha chains.
Sequence:
MGCTVSTQTIGDESDPFLQNKRANDVIEQSLQLEKQRDKNEIKLLLLGAGESGKSTVLKQLKLLHQGGFSHQERLQYAQVIWADAIQSMKILIIQARKLGIQLDCDDPINNKDLFACKRILLKAKALDYINASVAGGSDFLNDYVLKYSERYETRRRVQSTGRAKAAFDEDGNISNVKSDTDRDAETVTQNEDADRNNSSRINLQDICKDLNQEGDDQMFVRKTSREIQGQNRRNLIHEDIAKAIKQLWNNDKGIKQCFARSNEFQLEGSAAYYFDNIEKFASPNYVCTDEDILKGRIKTTGITETEFNIGSSKFKVLDAGGQRSERKKWIHCFEGITAVLFVLAMSEYDQMLFEDERVNRMHESIMLFDTLLNSKWFKDTPFILFLNKIDLFEEKVKSMPIRKYFPDYQGRVGDAEAGLKYFEKIFLSLNKTNKPIYVKRTCATDTQTMKFVLSAVTDLIIQQNLKKIGII
The following text describes a protein:
Function:
Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR). Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters. Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins. Up-regulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition. This arrest promotes apoptosis for viral release.
Subcellular Localization:
Host nucleus.
Domain:
In the N-terminus, the endonuclease region is involved in binding to the origin of replication on the viral DNA as well as to the overlapping viral promoter p6. In the middle, there are the ATPase and helicase activities. The C-terminus probably contains a transactivation domain.
Sequence:
MELFRGVLQVSSNVLDCANDNWWCSLLDLDTSDWEPLTHTNRLMAIYLSSVASKLDFTGGPLAGCLYFFQVECNKFEEGYHIHVVIGGPGLNPRNLTVCVEGLFNNVLYHLVTENVKLKFLPGMTTKGKYFRDGEQFIENYLMKKIPLNVVWCVTNIDGYIDTCISATFRRGACHAKKPRITTAINDTSSDAGESSGTGAEVVPINGKGTKASIKFQTMVNWLCENRVFTEDKWKLVDFNQYTLLSSSHSGSFQIQSALKLAIYKATNLVPTSTFLLHTDFEQVMCIKDNKIVKLLLCQNYDPLLVGQHVLKWIDKKCGKKNTLWFYGPPSTGKTNLAMAIAKSVPVYGMVNWNNENFPFNDVAGKSLVVWDEGIIKSTIVEAAKAILGGQPTRVDQKMRGSVAVPGVPVVITSNGDITFVVSGNTTTTVHAKALKERMVKLNFTVRCSPDMGLLTEADVQQWLTWCNAQSWDHYENWAINYTFDFPGINADALHPDLQTTPIVTDTSISSSGGESSEELSESSFFNLITPGAWNTETPRSSTPIPGTSSGESFVGSSVSSEVVAASWEEAFYTPLADQFRELLVGVDYVWDGVRGLPVCCVQHINNSGGGLGLCPHCINVGAWYNGWKFREFTPDLVRCSCHVGASNPFSVLTCKKCAYLSGLQSFVDYE
The following text describes a protein:
Function:
Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPAQDNDNNTSAFVNEFLAGWDDDDPFRSPSPETAGTNKTNNKKRKEPDTLGIDKEIDVTKKARVPRVKLDDARLLSDKGIPKLRKTASKLKLKGKGHEFSDAARLLSFYQEWLDDLFPKATFVDALAMCEKAGHKTTLRNARLKWIAEGKPRSTTAEEEEDRDREGQPSASAEPTRMAPIFEKATGAKSKTPTLDNNLFGDDDIYNATPRRNQPTAAPGDIPDDDELDALMAEAESGAAPGASKATNNGAASDSIFGGGAINRRPRPSEVPDDDDLDALMAEAESYRPSTTNHGSIFGNGSASGGGKDKPAMAAPPQEDDDDLDALMAEAEMHASLATKTTGKESTSRERTSEQDGGKDAQNYDEDDLDAWMAEAEAYTKTTSIQVAQPKDTDDDWEAEAAMAEMHGF
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MPGETITLQVGQCGNQVGLQYWQQLATEHGIQSDGSSTPYPKDINDLQLQELNNSGSSPQSYPQQTKPNGKYRNDHPELFFTLSDSNTYTPRSILIDMEPSVIAKSTSALPMFNPRNVHLSNQGNGAANNWINGYKYGTEEEETLLNLIDREVDKCDNLSNFQLFHSVAGGTGSGVGSKMLEVISDRYGHKKLLNTFSIFPSNEDTSDVVVQPYNTILTLKRLIDYSDATFVFHNDSLNRIENILFNNNSNIQHDDNDLFLGANKLIALVSASVSNPLRFPGYMYSSMESIVSNLIPTPDLKFLTSSIAPFSTQKHNYLNEYDMLLELSNDRYKTNRVGGDTSYISMLNYLIGYNLDQREIRKGILKSQQRISFVPWVARSVLVVHGKKSPYLKNTNLEGIQVTNNTSMIDVFTKILKQFDLLIKRKAYLNRYYSSVEEENEVMEMFNESRESVKSIIDEYKACKEITYLDDDDEDDLEDGGGNGNGYNNIDDADMGI
The following text describes a protein:
Function:
Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD. Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA.
Sequence:
MKLTIIRLEKFSDQDRIDLQKIWPEYSPSSLQVDDNHRIYAARFNERLLAAVRVTLSGTEGALDSLRVREVTRRRGVGQYLLEEVLRNNPGVSCWWMADAGVEDRGVMTAFMQALGFTAQQGGWEKC
The following text describes a protein:
Function:
Could form pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system, generating rapid, transient inward currents that fully desensitize upon extracellular acidification.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRGGGFVQIFKDFSNWSTVAVVPHVANANNKISRIFWIAIFLFVLGMFAYELYILIAKFFSYPATVNTEILFEKQIFPVVTVCNMNPYKYSVVKSNSAFSSVNTLMTTYSDATVGTFSTDKWGLYADNDETYDLDSRAADALVLEANLISDTAKVPALYTYADLIQDCSFAGIPCSESDFTKFIDPVYGACYSFNEDASLNYSVSREGIQFGLKLMLTVTQTKTNGNTDSLPTTKLAGARIGVNSRGSSPGLDSNGIDAGVGYESAVSVSLTQNVRAKKPYGTCVDREPDSSDYYKDFIYTLETCFNGCKQRDTIAKCQCANPRLALGSTDTACQPIKADLDCLQTLKGNQTSSTPNIDLLVECNCNPPCDESTYTPTVSLAQFPSTSYYVATSSTAGVGSCSSTNSKFSSKSDCQKWYNNNGMIIQVFLETLSYELYTETAGYTVSNVINDLGGQAGLWLGLSVISVVEMTGLMLVMGAFCVTGGAIKMAPDDDEIENDHRIKDVEDVKKEIDHLEKKHGEMESGSDGEVDDIENKGDEEKKKK
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFLTRSEYDRGVNTFSPEGRLFQVEYALEAIKLGIGVQCEEGVVLAVEKRLTSPLLEPSSIQKVVEIDYHLICALSGLVADARTIIDHARIETQNHRFNYNEPMGVESCVQSICDLALRFGENRNSGEERMSRPFGVALLIAGIDEKGPSLYYSDPSGTFTQFHAKAIGAGSEGAQTTLQEKYSKTLTIAECQKLALTTLKQVMEEAITTTNVELAVITKADQKFKIYNKEELATVIQTLE
The following text describes a protein:
Function:
Involved in the differentiation of epidermal cells, probably via the regulation of the expression of meristem-related genes (e.g. CLV3, STM, KNAT1, CUC2 and AG) and of leaf polarity-related genes (e.g. YAB5, FIL, AS2, PHB and PHV). May play a role in regulating cellular proliferation (By similarity). Necessary for flower development, probably by preventing apical dominance through the down-regulation of AG expression. Required for embryogenesis, leaf and cotyledon development, as well as for leaf polarity establishment. Plays an important role in plant growth and senescence by modulating ribosome biogenesis in nucleolus. Possesses GTPAse activity in vitro. Possesses RNA binding activity in vitro. Associates with ribosomes.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus.
Domain:
The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis; In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern; The DARXP motif is also sometime designated as G6 region.
Sequence:
MVKRSKKSKSKRVTLKQKHKVLKKVKEHHKKKAKDAKKLGLHRKPRVEKDPGIPNDWPFKEQELKALEVRRARALEEIEQKKEARKERAKKRKLGLVDDEDTKTEGETIEDLPKVVNVRDNSERAFYKELVKVIELSDVILEVLDARDPLGTRCTDMERMVMQAGPNKHLVLLLNKIDLVPREAAEKWLMYLREEFPAVAFKCSTQEQRSNLGWKSSKASKPSNMLQTSDCLGADTLIKLLKNYSRSHELKKSITVGIIGLPNVGKSSLINSLKRAHVVNVGATPGLTRSLQEVHLDKNVKLLDCPGVVMLKSSGNDASIALRNCKRIEKLDDPVSPVKEILKLCPKDMLVTLYKIPSFEAVDDFLYKVATVRGKLKKGGLVDIDAAARIVLHDWNEGKIPYYTMPPKRDQGGHAESKIVTELAKDFNIDEVYSGESSFIGSLKTVNEFNPVIIPSNGPLNFDETMIEDESKTQTEEEAEHESDDDESMGGEEEEEAGKTKEKSETGRQNVKLYAAESMLNTKKQKAEKKKRKKAKKAGADEEDLMDGDYDFKVDYRKNKDGEDEEFQIDAKIPMAGLLPEE