lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MALPYHVLKVCDGIVFAARGSNIHSFDSNFNPISVWKYPVKQQETNGEKAESETPAPVVEAEESPAPEGPPVKKRKVEDGEVVAVTEENKEESKEDTTEGQTETKTESQTQEVNRRSRRQKQKQKTEGGWAKNNKAVLEKPFVQGMYLTTDGRHLVAITGSDKTIWVFEHDGAGNLKQLSQRAMPKRPCALALTPDDKTILSADKFGDVFSLPLLFTPAEPTAAADVTTTASEVATPEPTPSAPATPAIPTPPTTDVAKAQSLSVKPQANELTVHTLRNLKALENQKRCLERQKAAKLAAALQASQFEHTLQLGHVSMLTSVAVAVHPSHPGRTYIITADRDEHIRVSRGIPQAHVIEGFLLGHDEFVSRVCIPEARRDVLISGGGDDDLFMWDWVSGKLLGKAPVLAEVKKALPSAEDAEKVTKVAVTRIFDVQQGAKTQIFVICERIPLLLIFTLTSTNTLQHTQTLSLLGNPLDVEYLKAESKLLVSIDPNTSSETQEEEASNGGVSSILALSFDDSESSWKVTIGGLKATEAAEEESSSLSPQDLQKLLYTTESLRKTNKDDE
The following text describes a protein:
Function:
Required for proper chloroplast development, most likely through regulating plastid-encoded polymerase (PEP) dependent chloroplast transcription. Acts as a component of the transcriptionally active plastid chromosome that is required for plastid gene expression.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAASLSFTRFLLFPRCHSNWPCYPSLNFMQLQDIRLHSKSGIAAASRKKAADSFGEEPADENGAVVKKKTTRKRAGRPARKKSVSDITEEKPELVVASDATSDESIISALSDDSKKTRRRTRKKAVSASTSLEEEKTEKKVRRRTKKKDDRDVEDPGSEAEVTDHEDIEESPFIANMEVEIEEDLELGMMEGEDISYTYGWPPLVCCFGAAQHAFVPSGRPANRLIDYEIHESMKDTLWAPEKYIRAPGGSAGSVAIALASLGGKVAFMGKLGDDDYGKAMLYYMNVNNVQTRSVRIDSKRATAISQMKIGKRGNLRMICAKPCAEDSLSKSEINIDVLNEAKMFYFSTHSLLDRNMRSTTLQAIKISKKLGGVLFYDVNLPLPLWKSVEETKMFIQQVWNLADIIEVTKQELEFLCGIKPSEEFDTKNNASSKFVHYNPEVVTPLWHENLKVLFVTNGTSKVHYYTKEHNGAVSGMEDVPITPFTCDMSASGDGIVAALMRMLTVQPDLITDKGYIEHTIKYAIECGVIDQWLLGQVRGFPPKEDMEEEVVPDPNGIRSITEMEYRTLMPVS
The following text describes a protein:
Function:
Plays a role in mechanosensory transduction (touch sensitivity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; Extracellular side.
Sequence:
MRSSLLLLVFFLSIGWARYCVHNEKSWCQGHNIWGWCFHNKSSGVFNCDDNAFCVSQEQLKNKKSSGCFLRDNSSICCCNDADGCNLGFIGVQPKYAHGQQCTNSMEVPNEDIRQFRPCDDPFCYSVLTAEDDGGPTTVTRGCHSRKMVMHHMSKNEDDKYQNNTKWRETKQIAEMPSCAEILKDQPKVNGTTSMCVDFTYDQEAEDGEEVDEPIKMKGRLCCCAGSNKCNEHAMWADEGISLTEMLEEIEARKVPVDSSAPVNIILSIAFSIFLIHF
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYGNPHKEPVAIAVIGGSGVYKLNCLQDAVYHDVPTPYGNPSGQLCVAKVDGVPCVFLPRHGPHHQYNPSEINYRANICALKQMGVRYILAINAVGSLDESYKPGDLVLCDQIIDKTYMRKATFFEDGVVVHADFAHPTSRIFNSIVHEALLRCFPDVAAGKGTFQIHSSGTLVTMEGPQFSTKAESLLNKQMGGHLIGMTSATEARLAREAEIAYATVAMVTDMDAWSDAPHVDAAQVTKVMAANVEKAQRYPPEIIKSLAQNLFDDPAHHTLEYAIVTKPEHIPAETKQRIAPLVASKYPQFAP
The following text describes a protein:
Function:
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSDDKHSKTEKPTAKKLDEAKKKGVPHSRDLTSTVTLIAAMVALYTTGGFMFTTLKRTSGELLGSMGTFHLTEASVEHLLIKLFLVFLSVVMPFMLVVVISGLATTMVQVGFSMNSERITFKLDKLNPVTNAQKLFNKDSLVEMLKAVLKIVIVGYMSYKIMRDEMDGLLFLADTDLAGILEVFKHLAFKLVIHTCGVLLILGVLDLAFVKWRFIDNLKMTKQEVKDEHKESEGDPKVKGKIRQMQFQQAQKRLRKVIPTADVVVTNPTHYAVALKYERETMAAPLVLAKGVDHMAQTIKAIARENNVMLVENRFLARELYAQVKEGQPIPESLYTAVAEVLAYVYSLKGKI
The following text describes a protein:
Function:
The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MESSTINAKKISVLLTLFSIIGYTAYSAHESILEIRQDGKLPLDIKCEVILVTLLFTFTTVIIASPLRSIQLNKWSHQRSDLAFLNSRTNFLRIKELKEKIEKVKN
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endomembrane system. Membrane; Multi-pass membrane protein.
Sequence:
MSNAITSVIIASTSATAKVFVIGGIGYWAAASKSPILPPHALTPISKMNFNLLILPLIYATLASSVTPEKIGSLWFVLVSAFGVISLSFGVATLLGKLPFFRVENKIDFDALRIAAAFPNIVALPILIFPTLCEFAVVHDSFYTEGDDVNEEATQVEKYRSCVDQSNAMIFVYFFAWNFLYWVLGYETLVRAGSKRQIHNEETLSTETSVVHNTDDSFEAVNHHQQQQLEQEENGGLEGRVTPKVIENECTTGEEVAIPNEDKKTSVLRLIATALFKTISSPGFVAMILGFITACIPPLRDALFEPGGALRFFGSAMESLGSASSSVGTIIVAASLVHQANDDNIRDGREDSIEHDDNATQTHQLHNECESSDTIQQTQSTRRRSSMSQFGGMVRRRSSLALQSIRKLRKPTLQMHAWFITSRLIVAPAIVSLIIIGMDCGGILSDIPSLAKMVVIVNAGLPGAQLCVITLKSKGLTDSASIVAKVYLPSYLLSAVTIAAWTSIGLLVSIPDEDGNSFCNR
The following text describes a protein:
Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
Miscellaneous:
MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAIITTNSDYFAHRYEVIIPFVVSTICSIVGIIGNGFITVIYGTEWVRSKRLPTGENLMLMLSFSRLLLQIWMMVEITYSLLFPIIYNHNAMYKLFKAISVFLNYCNLWFAAWLNVFYCLKIVNLAHPLFLLMKQKIIGLMPRLLSLSVLVSFSLSSFFSKDILNVYVNTSVPIPSSNSTKMKYIFMINVLSLAFLYYMGIFLPLFMFIMAATLLITSLKRHTLHMENSTTGSRDSSMEAHVGAIKSTSHSLILYIINALALFISMSNILGAYSVWNSLCNIIMTAYPAGQSVHLILRNPGLRRAWRRFQHHVHLYLKR
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAARNSNTALVKQLQRLKSQQVVEYENFDVRKKVSVLFQFKEAADFDDETIFALGVNGLQGLINANKRNFEEFANDLFHIDSQSVYRSQLTQDENEAISQRIRSFLLRLCPYFMLQAAMKCMEWLIRRYSIHQFNTDDVMVCILPYHQTQQFVRVLQVLPIAHDRSRWNWLKNNRAQGVPLSSIILQQRCLSDLSILTLICRNLQDSLKYNINASSTVVVNFYTSTIVGLLDSSHSDKMNEQFMITLTPYLIKGLKSKHNESIAGTYIIITQMMMKMTFENKFCTMLIDCVTKHLSPSLQVEAIACITCICQSQNVQTLSWSKLLKLYCHQRHILTDDDEINVLKETVALILKSINSRYPSVIDDGIKDFIDQTQSKNDSNDIDPLSGRNSILWIEEMVYLATAISKYKVIPECDDRPLIVSLYHPEAKIRSLAVRHIQQNLLTQKVDTDNKQFYYEALINRWQDDDYTVVSSVLNIGQNLTQIFDMQHLSEMLINKCNELFLDENLLSQEVLQNILTIMLDRWFLEDLKDFDTIFVAIIPHLIWLPKRKGFSSKLILKLAKSLLVSKHPLLHDIKSLISNKTVKEALAADQGSKVAKVNNAICKWLTSNLTQDNIQNFLDNCSNQSQKFRSDTQRDVFNSFIYCVCYQWVKHWSTQQKQLNSASINCLILYLYEDLRLLASHRGHQLQVEFDTGDGIENNDDAIVTSFFNTIPIMIRKCDSKRYKKSKSMFLLRFLKALLGVLPSQNAEVDWWKWTDEYQAKIKLVDLIAYGSGILFKLKYQLYFRYLTKELLMELSNKDRSNFLNSSPILQCYSLNLATALIQGATDKILKDLMNSSCPLVPSLLVPINSENPCVRKAAVIFLKTCIDRIHAIDSSVMAFAFANISSTICQASETIVADREQISKVFASHFDKLTADVKSKEKKSSRSKAAILKRAKESAIEANFNCIMEHVTNLQTPPIIRYNVLTSLQQVNNTLKLKFGMEFFMRLLDIVQSEQIFDLRQEDALCLQNFLNCFTKDVAKNLATEPLLLNSFMTALSIPNDIPYLAHQSPQTLSLTQVTPGFFAAIKDEKIQQKIFSYLCDQLLIASAVERSSTIPLTLSKIPLTAGQYNTEFTTLNFTSIKDQTSKRPRKQICMELDDSDIEYGKQLLLSNIIWTCKIVHKDILLEEYFDVEQVVNCIRKSDNPQTHQQALLALNLIANIFPDLLFHNVMSVFTFMGANIMKHDSAYNFQIINQTIDAIIPPLLESNTLESQMKIEINSGKGVMTSVGDVITRVIQVFVDAWAHIPSHRRVPLFEHLLRKSGSCRSLSTTLLMLVESEISNVDEDTTAQVNRDNKIDFCLPLYQKFDVVTQLDAIIDCVKYISNLSDDQRDSKPVTGRSRKSPETLQILQIFDAETHTSKQLRRYRYTVAGLIVNLMDDSKYTEAVSDLKNDKTRQLEKKFIELLEESLRYITKISKLAELHRVESIGRYWNALNNRFNVIVDKVNGLLPLHAFIPVISSLLKSDNIVTCRKSFDLLGSKLVHVDLRTILELKTQVIGLVDQLLEIVIGSKDQLYIKEKALYCISSISSYLAPEDPPLFTHVIKGCLKVLTEPSLSMPVLAAALFCLSEICRGIGAHMIAFLPQLMPQIMKIFKLIRDESQGDQPSKKLEVLVTAAVKFAHRIISCLPHFVSPYLTELLKEFTRSYISGTLIDLNAKKSSQTSELVNELDGLREDTASLLPHILLPAIGQSYKEIMLEDDWLEVDTNRIAMLMSVVKISISKMPSVDIKSMQPKLINIFMEAFDYRITTQAKICSVSLDVSENAIIEAFLALVVRLSEKTFWPAFRKVFDWATVGDVPKERNIVFFRATNRIADTLKGLFLIFASDLVTYSAKLLDANNASKGGKFFSNNESDASIAEEKSSLLTELILDCLYKCFLYDRQKFFDQEKFDLLMQPLVDQIDNQIDGAAKYEERVLQHLLPCIVEFAVVIENDALWKPLHYQICLKTRHKSPQVRFASVKIIGELYRRLGENFILLLPETIPFLAELMEDESVEVEKECQEVVAVIENITGESVEKFF
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus.
Sequence:
MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSMMVQVC
The following text describes a protein:
Function:
Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).
Sequence:
MDNVEIHPLAWTADSETLIEAPPGFKWLAIEIASKTGAAVSGRPVWGSCDVRLDKRYKRIFHLGHGVPPNVAYLLEKNLGGKVERLDTDLYVLKAGGIEVYFIPVYYIPPPRLPLPQKGGKIYFPVPYRRIAEAVHRQTGFPMAREPITGCWVGEPPGNVAYVVATGLFYPLTLKLFYPESRVFQIDPFRGEVRDVEGDFARILKLKARAHVTEAKRVAVLLTTKPGQRQDEKARELAARGHTVVVLDEASPDYIDDLQFDLVINTACPRIGIDDLDRIKTPIINYYEYIHNRLDPRLAATLL
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MQVNDATELVASKASERLHLKAALPSKIIDISSLNAVPFLTQDAEHSGAWLDASAWLFKMVKTFEPFDTTPLPELYTKGFDLEQVWEQIRLLNEPLVPYLSKMASDFPKSDNDSIEETDDDTLNNLNGDDEQEFEDDSELDESELESDQESSNYLDLEAEEDNQGSQDSEDSEDNEELNSASDNEEFEVDFPDQESDQETAGPIKRKRSVVDDDFFSLEEMEKFADMGERHDIKAARKANMKDDDSDDDESEKDDMFSFDSDILNSNLDDEDEDNANDIRYEDFFEGIDKDADTKPSKKQRARPSWQDRDDMDRDEDIEPTDMDTSVNEDQEVDDTSLYTSHKQTLFEDDAEPIQGETLSTFEKQQARLQKAIQQLESEAMQEKPWAMKGEVSSRARPKNSLLEEDLEIEHTAKPVPVITEESTLTLETLITQRIKDQVWDDVTRKAPPKDTVYDPNRKFELIDEKSTKSLAQVYEDEYLRQSNKDQPTEKDIALNQKHEEVKTLFQTLCQDLDILSNWHYTPKAATLEVEVLPPVSVPAIQMEEVTPAAVSDAMLAAPKEVYQGNVAKSQMEMDAADKRKARLKAKREVQREHKMRETAKKEREAATGVLASQLTKEKAMKQLMGQSNVTIVGDKTSKRQMGRVSTEAKGGKTKLGKRDMQATVVQVGGKVGQTKTRIDKPSDLRL
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MSKVTNVSINTKLDELLKGDQVIINFGAEWCGACKVLEPIFNKLSTQYPLVTFLKVEIDKINVHESTKSITSIPTIMLYQKGKKTKEIVSPNETQLRKILDSMK
The following text describes a protein:
Function:
Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.
Sequence:
MHGFNESNFIPLRNSEGSPSCKKKNFQTTNEDGSVSPPHGGKKRRENISLGRTRKFDRYVRSTASPWVTRDYHPGLVGFHEEIEDFYEFMRPTEEERQMREYVIKSVEEVVLELWPTCKLDVFGSFRTDLYLPTSDIDIVLFGEWEHLPLWSLQKALVSKDIVAEGSVKVLDRAAVPLIKFQHKETLVKVDISFNIQSGVQSVELIKDFMKKYPALPKLIFVLKQFLLVRELNEVWTGGLSSYSLILMAISFLQTHPRSDSRDITNNLGVMLLEFLELYGRHFNYQSLCICVKNKGYITKEEFRKQMDNGCQPSLLSIEDPLTLGNDLGRGSYAVMQVKQAFEFSFRTLTNAIFHLNFNGNQPSLLSLIVYVPYDIMEYRRMAVAKVERLR
The following text describes a protein:
Function:
Mediates adenine transport. May be involved in the uptake of cytokinin analogs.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKMKTVLVIINCIFLAIGNCGGPLMMRLYFQNGGERIWFPSFLQTVGCPLIFFPLLLSFLRRRRCLEEQETTPFFLMKPPLFIAAIVVGLLVGFDNYLYSYGLAYIPVSTASLIISAQLGFTALFAFFMVKQKFTPFTINAIVLLTGGAVVLALNSDSDKLANETHKEYVVGFIMTLGAALLYGFILPLVELSYKKSGQRITYTLALEFQMVLCFAATCVCLVGMLAAGDFKVKHALFIFKNRVIAGEARDFKLGESLYYVVIVFTAIIWQAFFVGAIGLIFCASSLVSGIMVSALLPVTVILAVICFQEKFQAGKGVALALSLWGSVSYFYGQVKSEEKTKAQDTQLSQLPVTDYVA
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MYEYIKGTLTHINESYVVIESFGIGYAIMLSERFLVDLRAFMHQEVLIYVHSVIRETEHVLYGFSSRAERECFRLLISFSGIGPKTGLSILNMFPLQELCSIARLENVKAIASVPGIGKKTAEKLMVDLKQKLPTLMPLYLEEPVVPSSTANSSFKEGIGALMNLGFSRLAADRMMTEAVKELSEEASVAELLPIALRKS
The following text describes a protein:
Function:
Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus.
Sequence:
MAIPITVLDCDLLLYGRGHRTLDRFKLDDVTDEYLMSMYGFPRQFIYYLVELLGANLSRPTQRSRAISPETQVLAALGFYTSGSFQTRMGDAIGISQASMSRCVANVTEALVERASQFIRFPADEASIQALKDEFYGLAGMPGVMGVVDCIHVAIKAPNAEDLSYVNRKGLHSLNCLMVCDIRGTLMTVETNWPGSLQDCAVLQQSSLSSQFEAGMHKDSWLLGDSSFFLRTWLMTPLHIPETPAEYRYNMAHSATHSVIEKTFRTLCSRFRCLDGSKGALQYSPEKSSHIILACCVLHNISLEHGMDVWSSPMTGPMEQPPEEEYEHMESLDLEADRIRQELMLTHFS
The following text describes a protein:
Function:
Transcription factor involved in endoplasmic reticulum (ER) stress response. Acts as a ER stress sensor and activates the transcription factor BZIP50 and the chaperone BIP1.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus.
Sequence:
MADPPPSSSLLLDPPFADLFPDNLSLPSDDLRDLDLDFDFDDFSVDDFLCSPEEPHHHASSHPSAADGSAVSSSSSLNQDPPHLAARPCSPESGDSSASGVFVADRGVKEEREKAGWGLKRKMETDDDGLSDGHADLNLNNPGSNPRSSKFRRSEEASSPPDVGSGGEVVEEKRRARLMRNRESAQLSRQRKKQYVDELEEKVKSMHSTINELNTKISYIMAENATLRHQLGGSGAPPAVYPPPGAMAPMHFPWVPGYGLRPQGSQVPLVPIPRLKPQQAAPTPKAKKSESKKGERKTKKVASASLLGLLFFMLILGGAIPRVNRWYEGNEADEGMSKMKSLSQTKGRIFSVRSRGSGPNSTVLCSRKKGFGEGGIDRVTGRRCEDVEAGSRVKPMGSTSWSSPGSEAVFTQNSTENLPAMLYVPRNGKHVKINGNLIIHSVLASEKAMQQAKERQSLGKEGKETGLAVAGNSMSALAISKPGKEVDQHSRSYRKASNSDDTYVNNLKATLADDGPMQQWFREGMAGPILSSGMCTEVFQFDVSPSSSSSSIVPTNSIINASSIVNASENLPPTSSHPRKKRNRRIMYPEPIPLRGTTTANNTEQFEKPSESSNFHNPKPVSSVVVSILADPREAGDGETDGRISPNSLSRIFVVVLLDSVKYVTYSCVLPFKTSAPHLVN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
GFDSIFTKALEISHLGQDKVCVTVTVTKGLLNSYGMLHGGATMTIIDIVGTLALLSRDVNKAGVSVEVNTSFISAAREGEQLIAEGRVLRLGRKLGYTQVDIINPKTGQLVATGRHTKAV
The following text describes a protein:
Function:
Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle.
Sequence:
MKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQVLSSGRHTGPAKLTNGKKATYLRKIPRFNADSGYSIHSDSESQAETVHGLDGCASLLRDILRNEDSGSETAYLENRSNSRPLESKRYGSKKKRHEKHTIPLVVQKETSSSDNKKQIPNEASARSERDTSDLEQNWSLQDHYRMYSPIIYQALCEHVQTQMSLMNDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQTDGNSQFASQGKTVSATCTDVLRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIPFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICSSSTKEAEDAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTVCDGSVFTSDLMSDWSISSFSTFTSRDEQDFRNGLAALDANIARLQKSLRTGLLEK
The following text describes a protein:
Function:
CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
Sequence:
MPARFAYDDTRHVSLRTPTDGVLESILVKTGDSVDRGQPVAVLRSPSIGTARNQILSEKANLELAQEAYRWEADIHAGVSDLAKRIRAGEAIDAIKQSLQDKTIGEFGGQLLTMYSKSNLANRLSRSVDDLGGSGAISGRVVQERQSDRQQSEAMLEAAIEQSLFQTRQSMIQAEAKRNEAERRLRIAKQTLGTLLGTLADSMGGLDVSPNELDVSRLTIQSPLSGTIESKAFSASERVAAQNELFVIADTSSLWVEADIRGRDWESIHVGQGDEVMVSTPAMNMPPHPATVYTVGRQVDPASGAIPLVAKIDNSKGHFRPGLFARMAVPIETRHDVILVAESALIDLDGQTSVFVISEDGFEPVTVEVGAQGGGMVEIREGLIEGQSVVVSGAFALKSELLLEGEE
The following text describes a protein:
Function:
Part of an antiviral system composed of AbpA and AbpB; when both are expressed from a plasmid they confer resistance to phages T2, T4, T7 and lambda but not RB32 or RB69. Resistance is temperature dependent, it can be seen at 30 degrees Celsius but not at 37 or 42 degrees Celsius. The system impairs phage but not bacterial DNA synthesis (shown for T4, T7 and lambda). Partially suppressed by mutations in T4 gene 41, a replicative helicase.
Miscellaneous:
MISCELLANEOUS: Part of prophage CP4-57.
Sequence:
MESNDSGGVAAKHGFLFQDCVAAYHVTRMLRDKTIRSVRCEVTDDIDIVSDGYIDFVQVKSTGKTRWNISDIVQNSKGADKKTIPCSSILHKSMQCESDLSLGRRYSIVTEEKVNKTLEYLTISPNARLDKPGRQELIDDLNKRTDNFLTDSGISVSDWIDAATWEVFSSLRELELLGIKNIRLASQDLHGVILSSETVAEDIWCRILDTVTRKGEHSRRIHSADDKSYLRPDLLEWFKQRVEDDQSRSGRKIYVKRDLPHILTPFRAPMASVCAKRKGQVLHQQYSLKKYRYKHIADNVCQWLDEVFLRPKEMSDIHKLTFIEKRERLKNSVFKSLHDVSEFLGRVLLHATIRQHHESQPIPCMLYVEKAGAEKILENVHIVRRDPEGDQLWIGFSELVTDINIAVRLPEIRDQLYEDISDCIDTARKKILDIKDDNYLLRHDIDEILDGSQPFDAHLDRFTFVLFVGYDSNLLTEPETPGFEDDLEKETAVLFEKFAADLIEDSPFANLCIHVFIYPAPSLERLTQLVDEKVREVV
The following text describes a protein:
Function:
Metallo-phosphoesterase involved in phosphate metabolism. Has a peroxidase activity.
Subcellular Localization:
Secreted.
Sequence:
MNSGRRSLMSATASLSLLLCIFTTFVVVSNGELQRFIEPAKSDGSVSFIVIGDWGRRGSFNQSLVAYQMGKIGEKIDLDFVVSTGDNFYDNGLFSEHDPNFEQSFSNIYTAPSLQKQWYSVLGNHDYRGDAEAQLSSVLREIDSRWICLRSFVVDAELVEMFFVDTTPFVKEYYTEADGHSYDWRAVPSRNSYVKALLRDLEVSLKSSKARWKIVVGHHAMRSIGHHGDTKELNEELLPILKENGVDLYMNGHDHCLQHMSDEDSPIQFLTSGAGSKAWRGDINPVTINPKLLKFYYDGQGFMSARFTHSDAEIVFYDVFGEILHKWVTSKQLLHSSV
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKLKEIDRTATFAWSPNNLRIATGTVAGTVDADFSSSSQLEIWDVDLMDRSSEGFRLTKPAVSISADTRFHDLVWHNTGKHSLIVGATESGSLEVWEADNIKDSSTSVSVKEHSGPIKTLQFDPHNPTRLVSGGTKGEIFVWDLSDPKKPIAKKLGTDNKAGDIESLAFNNITRNILATSSSNGITTIWNVDQNKELTRVKHDKPVSHVVWHPSKPTKLITAVADDAEPVMLIWDLKNANAPEGVLQGHSKGILSVDWCQLDPRFLLSCGKDNRTLLWNPDTHECLGEYGAAQNWTFKTKLNERTPDLFATASFEGKIVIQTLQDVNGGDAPAQEGDFFQNLGTQSQAKISLKQAPSWLQRPVSNSFGFGGKIVTVTTTDGKSTVQVGKFVGDKVDTESIEVVLKGDLTSAFDEVKGAEWKVLEALSKGTDEVRSFLDIPVMKEEPAVEDDSEDVFSKMSPSGAFSLESSDPINQAIINGNLSTAVDLCLKEDRLLDAFALAEKASDAVKTKVQNAYFAKQTSSTARLLNAVNTNKLDDVVENANLKDWKEILALLYTYGGAQFGDLAAALGDRLRESDRDNAATCYLVSGKLDKVSGLWESEITTREKELTKDNVAPYTAHFSALKEFIEKISVFRKATNAVDSGTVDGLYNKYREFANIVASQGNLELAQQFLALLPASFEGVGLERERLNKAAKPSVATTATSKASAYGKPSYGSATPQASAYTPTASAYGSMYAPAVPAAAAPAAAAPPPTAAAVPPSPAKNMYAPQPPAPVTGFAPAAQSPGAPQQNTHNPYNPTPQTNAYAPQGNAYSAAPQQNTYGRSTPGGGPVRTTAPRHDTAGYNDLPAGSVPPPKKSAPSPGPISSAYAPPTPAAPSAPPAGGPRPPSVNRVTSPGVPSGGVNAYGFPIGGAPSPYGAQAAYGARPPVPAVVSPPPPNPYAPAHSPAQNNVQPAVNPYAPAPGAVVSPPPVHAGIVPPPAQRSAPSNPYAPAPGAGAPPASNPYAPPTGGFTGAPAPHAGGGYTAPPPAQVAPPPAGPPRNSVAPPPGGPARNPVPSSPAPPPAAAKHPAGDRTHIPATSRPIFDTLSTQWAGLKPHIPEQYSKHVRDAEKRLNILYDHLNNDDAQPEMVEDLLKLSNAIAQRDFPTAQALQLQIATARPDECGKWMVGLKRFVEMAAAVRTW
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
Sequence:
MQSFRKIWNKPRPDDWMPLARFYYADSALNDIASELDSFDGRRDPDRCNALVTRLRVAQDRVLHIITEMLIHLYPREQDRACRDFRIKFPDEILHDTLPGQLWFGAECLSAGSNIIDHETESDLIRPLAKEVTKQLDILRDLLKNQSLRDPSAYNPVIKENLLKFDKLFAEFEYQYVSAMVPVKSVKEHDSQLDVAVLFSEVLSLALEKDLITQDLIDYCDPSVMIAIPRLGIVWGLLVYSEGALNVDVPAENLSEMFRPFYSLLVKIRNLLRILTPVELTRLETVLCKGETAVPEDSSSKLTMSDFRTNATDEEKAKNNQRVWMCDMPSDSTSSLDSDLRDSASEATSLASSGLTSPSSGSEDNLNRMVDKSDEELDDDVIETASSEENESDSNNENVEMVASSGDSSETESNSKENEEDVDEQATLQALAHETAEQLVAIKKKHEKHSKIIIPMQNEPRTLIDPKNLRSRFRSSEDLVHRLFVCIAGVADQLQTNYSSEIRKVLKIILQPSEVIPVYEVVNAQVANNSTEGEETGVEAQETLPLPAFMGVRWVPDEDCEQCTACSMPFNFVRRRHHCRNCGRIFCHKCSCNSISIPEHGYDRKVRVCNLCYVHRLNPFGCNEQSQASENNTGISSVAEQSSAQATSASS
The following text describes a protein:
Function:
Involved in chromatin-remodeling. Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The N-terminal DNA-binding region is structurally similar to winged helix domains.
Sequence:
MALSKAFGQKPVKFQLEDGGDFYMIGSEVGNYLRMFRGSLYKRYPSLWRKLASVEERKKIVESSHDHGYTQLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPAYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRSRLGRDKKRTFPLCFDDHDPAVIHENASQSEVLVPIRLDMEIEGQKLRDAFTWNMNEKLMTPEMFAEILCDDLDLNPLAFVPAIPSAIRQQIESYPTDAILEEQTDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGQGGEFVTTIAYSIRGQLSWHQKAYAFSENPLPTVEIAIRNTGAADQWCPLLETLTDAEMEKKIRDQDRNTRRIRRLANTAPGW
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in ribosome assembly.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MLWNTQYFRIEGMISLGWPRLAKTSILKFVPIAQNHRIRKMKVQDDFILTIDDSEDDIHYDDYDADAVDEEMPSNVELKKKSKKATPAKDSDFNGEFLFEADVNKDLSSATDMNWDFDMGSKTESNRASNTVDLDAIISRNRKPDDDEFPSSFPSEEELQEPEQENIDSDDEDLAIDGFGAGAIAENEDESSQDESESEEEDDITEPVPSFANISTQDFNSDSAAGSSDSEEDEEEIAKKNAFFAEGDKEKSMMTTTHSSFQSMNLSRPILKGLSNLGFEVPTQIQDKTIPLALLGKDIVGAAVTGSGKTAAFIVPILERLLYRPKKVPTTRVLILCPTRELAMQCHSVATKIASFTDIMVCLCIGGLSLKLQEQELRKRPDIVIATPGRFIDHMRNSQGFTVENIEIMVMDEADRMLEDGFADELNEIIQACPKSRQTMLFSATMTDKVDDLIRLSLNRPVRVFVDNKKTTAKLLTQEFVRVRPQRELLRPAMLIYLCKELFHRRTIIFFRSKAFAHKMRVIFGLLSLNATEIHGSLSQEQRVRALEDFRDGKCNYLLATDVASRGIDIKGIEVVINYEAPATHEVYLHRVGRTARAGRSGRAITLAGEGDRKVLKGVFKNSSAQNTKLVNRNLDFNKVEKFGKEIEELEPVVQKVLDEEKQERELKIAERDLKKGENIMKYGDEIRSRPARTWFQSEKDKQASKASEAKDKKSLAKRKKQMEKEEVPRAYKKTKNDRLSNKKSTKKSKSKRK
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Miscellaneous:
MISCELLANEOUS: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTFIITSPVFNPYFNAALEEWLLTEFRKNELVKVIYFWQNANTIVVGRNQNTYAEVNLKELESDKVNLFRRFSGGGAVFHDLGNICFSIILPRTGKVMENAYEQTTRNVVKFLNSLNVPAVFHGRNDLEINNKKFSGLAEYIAKDRLLVHGTLLFDTDFSKLAKYLNVDKTKIASKGVDSVAKRVVNVKEYLPNWTTAKFLEEMINFFTVTEKAETIVLTKDALAKVEKRAKEHFQSWEWNFGKTYEYNFKNKRYFNNAGLFECNVQVEKGTVVDIKFYGDFLSVVDITPVTKKLIGQKYDYKTFEKLFNELDHFSDYFGSLKPEQLLGVIFDNK