lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
Sequence:
MELKVVNANCGYGKKTIVSNISMKIKSGEIMCLLGPNGVGKTTLFKTILGLLALQSGEILLDGENVKKWSKKDFAKVIGYVPQAHTPPFPFTVLEVVLMGRTPYLGACASPTKKDTVIAEENLDLLGITYLKDKVYTDISGGERQMVLIARALAQQPKILFMDEPTSNLDYGNQVRVLERIVTLAKTGLGVIMTSHSPDHAFLCSTKVALLQRNGIFEIGAAHEIVTENNLRSAYGVDIMVASVTGKNGDSIKTCIPMLS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it (By similarity). Required for SK7, but not U6 snRNA stability. Required for dorso-ventral patterning in oogenesis and for anterior-posterior pattern formation during embryogenesis, possibly by binding and stabilizing 7SK RNA, thereby promoting formation of a repressive RNA-protein complex.
Sequence:
MEKRLSDSPGDCRVTRSTMTPTLRLDQTSRQEPLPQQPDNGPAAAPGKSKSPTPLPGKSQAAQHHQFRAPQQQQGPKNRNKAWSKRQHKAGGKHNPSACVGASSGQAQSTGSSVIAATLLPTAASAHKADLENIQNIHNKNLTAGGGVNHHGNAGTAHHGGGGGAGAHHAAAGGHHHHHNTRLAQNAAAGGASGGGTIQMHKKMLRGHHHHVLCAGNNANHTCCLVTGCNGSSIGGVGVAGSGGATASAGGGGASCKEAQSCKDTSSLSGNSSIAGSAGAGNAVHYCCGRSKFFLPEKRLRKEVIVPPTKFLLGGNISDPLNLNSLQNENTSNASSTNNTPATTPRQSPITTPPKVEVIIPPNIHDPLHLLDPVDSMEYEKQLTSPMKRAGPGGGMLHHRQHHYRTRKNRKRRRFDSNNTSHAGDEGGVGSELTDEPPLPAATSSLAASPVAAPLNVGGSLLLSESAAPAPGETAEMGQQQEQAHVHSPQSASTTTTAAEMPTPTPTSAAAATATAEHKEQSAPAPTATSSPQRQQQHVAAAAEELPTPETSAAAETPAEEMLLSCSATSASLVASTLAERRASRDLRLDLSSTCYGVGGTGLSFGGSISSSVGSSFGGGGRKRKISESSTSQKSKKFHRHDAMDKIVSPVVPQPGAWKRPPRILQPSGARKPSTRRSTSVSESELLSPVEEQPPKQLPLIGVEIPRDDTPDLPDHGLGSPLSTTSGATSHTAGEQDSLAGVDISMGDTLGSGVVGKAPLTSSLMLEPAKIPPIKMLPKFRADGLKYRYGNFDRYVDFRQMNEFRDVRLQVFQRHVELFENKDILDIGCNVGHMTITVARHLAPKTIVGIDIDRELVARARRNLSIFVRIPKEEKLLEVKAEPTVDAKANIAVKDETSGAAHKKTRRGKRRRKVHQGIHHHHHHHHDLEQLQQQQKLNSLLVKPHEFFPISFPLTYGRIPRILSSSKSPNMLGNKNQFPANVFFRHTNYVLKDESLMASDTQQYDLILCLSVTKWIHLNFGDNGLKMAFKRMFNQLRPGGKLILEAQNWASYKKKKNLTPEIYNNYKQIEFFPNKFHEYLLSSEVGFSHSYTLGVPRHMNKGFCRPIQLYAKGDYTPNHVRWSDAYYPQTPYEAYRGIYATLPVHRMGGGGSSAGGSNSGHAQMLHLSSSSRSQNYDTPHYAGSASGSASCRQTPMYQPTYNPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGSVRDAELDGDGSGGGGSGGGSYHRHVYPPNDDTCSPNANACNAFNSIRDADTDDSNQLPGGSRRHVYATNCGESSSSPQVNHHDAVGEFVDGLMDDEQKSSTGGGTGGAAYCDLSDA
The following text describes a protein:
Function:
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MFRIIKWLIALPVGIFIFFNAYVYGNIITYRAVAPHRTAFMSMRMKQFEQEGRDVALDYRWMPYKRISTNLKKALIASEDARFAGHGGFDWGGIQNAIRRNRNSGKVKAGGSTISQQLAKNLFLNESRSYIRKGEEAAITAMMEAVTDKDRIFELYLNSIEWHYGVFGAEAASRYFYQIPAAKLTKQQAAKLTARVPAPLYYADHPKSKRLRNKTNIVLKRMGSAELPESDTD
The following text describes a protein:
Function:
Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34). Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons, GAC and GAU, thereby regulating protein translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSILILEAFYGGSHKQLVDLLQEELEDSVLYTLPAKKWHWRARTSALYFSQNIPTSEHYRILFASSVLNLTELAALRPDLGKLKKILYFHENQLVYPVKKCQERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSIGKFMKLIPDHRPKDLESIIRPKCQVIYFPIRFPDVSRFMPKHKAAHLQKILSLKENGGNAPSTALPFQQQLRGSENLLKSFDSKSGPCDAAQQESLGCSVRQASYLKTFNSSDDSSTHHGEHKQNRCDVLAEADDQQRPLHIVWPHRWLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDITRKHLYKGEMAPFSWAALHGKFRSLLTAEPREDL
The following text describes a protein:
Function:
Dephosphorylates the phosphotyrosine-containing proteins. Involved in ethanol stress resistance.
Sequence:
MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGGWHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGFKNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL
The following text describes a protein:
Function:
Has bactericidal activity.
Subcellular Localization:
Secreted. Cytoplasmic granule.
Sequence:
MGIFLLFLVLLAVPQAAPESDTVTCRKMKGKCSFLLCPFFKRSSGTCYNGLAKCCRPFW
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MSEPRDRIIAALDLGTSLTKVVVARPVSEYEVEIIGTGAYPSSGIKNGSIINIESTTRSIIEAVSEAELMSGQEISVVAVNITGKTVKADNSKGVVAITNRDRTVTEPDVVRVIEAAQAIRVPADQQILHVLSKEFSVDDQSSIRDPIGMTGVRLEAEVHIVTAGITAIHNLEKCIESSGLGCEVMILSSLASSEAVLTSGEKDLGTAVLDIGAGSCDLIVYVDGGISYSSVIPFGGINVTSDISIGLKTTLETAELLKKRYGHTILSEIDPTETIEIPPISGRPARQVLREELVSIIEPRMREIFEMVDKELEKSGKKGFLAGGVILTGGGSLLEGIDTLAEDVFRLTSSRARPGGITGLAEKASSPEFSTAIGMIKYADRMTDMDQKSVDRSEGWSKKIRRWIEDNL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MGIRAVGFLKPSEYGDDASKYLNKFREHLFQLGAFGFETWTCKIYSRKAQTDSILRLISFNDTPDQNILITKSTTLVGDANFQSVLKDIGLPFDKTLIFKIDGSMAQLGDFKVRYGVSIVKEKQVGILFDIEYLPVTKLSVNSDLIFSSVCKTMDLQAKLYTPQNSESNEYNFSCLGQDYIRILLDNDIAQ
The following text describes a protein:
Function:
Essential protein. Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released. Controls the transcription of the psaA gene and thus modulates photosystem stoichiometry. Thereby maintains a harmonious electron flow and photosynthetic efficiency.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATAAVIGLNTGKRLLSSSFYHSDVTEKFLSVNDHCSSQYHIASTKSGITAKKASNYSPSFPSSNRHTQSAKALKESVDVASTEKPWLPNGTDKELEEECYDDDDLISHSVEAILLLQKSMLEKSWNLSFEKAVSSEYPGKGTIRKKKIPVITCSGISARQRRIGAKKKTNMTHVKAVSDVSSGKQVRGYVKGVISEDVLSHVEVVRLSKKIKSGLRLDDHKSRLKDRLGCEPSDEQLAVSLKISRAELQAWLMECHLAREKLAMSNVRLVMSIAQRYDNLGAEMSDLVQGGLIGLLRGIEKFDSSKGFRISTYVYWWIRQGVSRALVDNSRTLRLPTHLHERLGLIRNAKLRLQEKGITPSIDRIAESLNMSQKKVRNATEAVSKVFSLDRDAFPSLNGLPGETHHSYIADTRLENNPWHGYDDLALKEEVSKLISATLGEREKEIIRLYYGLDKECLTWEDISKRIGLSRERVRQVGLVALEKLKHAARKRKMEAMILKN
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1.
Sequence:
MAEPLLKRTLSRLRGKDRSRRKTEPKLSEAAVSSEMVQPSSLSSSPSMKPTQATSSDAPPRPRNFITVAKKQQWAQQGAAAPPPFLNPNHRPLELRDPSGRCQDPPEQSLGHNVRQEKNQHEGDRMLTSYTGDATSSTCALVSTATQHEASQPTCSYNDKPASSINTKLSGQRSYLQSLDRTSRAWVLSSGKSHESDNLLSPREDNGSNIWYNPIPEDEATGSPLREEVIWKRRSEKIGVPKNLETETRVQLEGEVDGPLDPLTLSHQAEDISAEKPDSPPSDSSPASQKKGSVIDKLRSPGTVRKLSLRMKKLPELRRKLSFRSSSRAYRHGNNTGDSEDTKTTASGASNQNVISKYHLDSSTPPARPLRRSSRGRSASKGGYLSDGDSPELLPRQQAPQVSSPQEVPCDVSSFRLYLGADPPRCSQRVTGLLTVHLLGLEDMKTSRSENSKDIFVAIQIDGATRARTALLTLKGSSLTLNHTFHLELERARQLRIVVLTPANPAAGGHQPATSGGPTRNRVCCLGGVSIPPLFKGSRSQQLCVKLEPRGLLYLKLSLQEKWDTQPMGDTSTPANVFGIELHQLVEKEESAVPVPLLIQKTVAEIERRGLKVVGLYRLCGSAAVKKELRDWFERNSSAVRLSEDLYPDINVVTGILKDYLRELPSPLITRTLYQVVREAMAIRTAPSPPESPDPQLSRSTVGLLSCLPTPERATLSLLLDHLSLVASFSSFNRMTHQNLAVCFGPVLLTPTQEAWKTGGGGRAGKGAGKGFGPGEEMNGAVDFKRHIEALHYLLQLWPVPTHHSADNNPYPSFSLASSQNPLDQLSHPVINRPQNREEEVVVSRRGRAGVTRLESPPLINRYAGDWSVCGRNLQLGQEADYDEVAGSESDGGSRDEDEEEQKEVWSSGGGGRGSLYVDEFVDFDAPFNCRLSLKDFDTLIHDLDRELAKQINICL
The following text describes a protein:
Function:
GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (By similarity).
Subcellular Localization:
Cell projection. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, phagocytic cup. Nucleus. Cytoplasm, cytosol. Note=Localizes at the leading edge of migrating cells. Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content.
Domain:
The BAR domain mediates interaction with the exocyst components EXOC4 and EXOC8 and is required for the function in cell migration. It also mediates the interaction with PLXND1.
Sequence:
MMKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMTCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQAAKNSGSNQGLGGASGSHTHTTTANKVEMLKEEEEELKKKVEQCKDEYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALAELRDNHSQADHSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVPAPATTPAPTPAPASMAVRERTEADLPKPTSPKVSRNPTETAASAEDMTRKTKRPAPARPTMPPPQPSSTRSSPPAPSLPPGSVSPGTPQALPRRLVGTSLRAPTMPPPLPPVPPQPARRQSRRLPASPVISNMPAQVDQGVATEDRGGPEAVGGHPPPPALPPQPRPRGLISETE
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MGSSSGAPLEKMIDGDPDAVHIISTLSCQHNTSVHDAADTSESSPSPSKPAVQWSVFKDADVDAEDKSESRKLEMLKVLQSRECVKLEPLVLNRDSFTETAANILTLSVLVKDGLAQVRLASDQSYIIVPRRTTDAALKDDDTKSIFQLNYKDWESMRKQVQASEELMAHENAPFKWPAVIPKGIRQKARRRRTCFKPGDGTLAQAENRNEEGATSSADPELSAPGYQDFKPHKALLTYSRRREKRRAIPGQADPKEMLVKRYTRRVLNGEIYVEKTFVFQELVPTKKPKVDAEGLFETPKQRRQPGLYTPVSTSTSTGEGCTLAVYTKAALEGVESGDAMIIAPKRFKKSSGLRPRHVAIAQIKAKLKALLNKQAPLK
The following text describes a protein:
Function:
Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters. Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (By similarity). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (By similarity).
Subcellular Localization:
Apical cell membrane. Cell membrane; Single-pass type II membrane protein. Cell junction. Lysosome membrane. Melanosome. Basolateral cell membrane. Note=Localized at the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the apical membrane of placental syncytiotrophoblastic cells. Recruited to lysosomes by LAPTM4B (By similarity). Located selectively at cell-cell adhesion sites. Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity).
Sequence:
MSQDTEVDMKDVELNELEPEKQPMNAADGAAAGEKNGLVKIKVAEDETEAGVKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPVQRWWHKGALYRIGDLQAFVGRDAGGIAGLKSHLEYLSTLKVKGLVLGPIHKNQKDEINETDLKQINPTLGSQEDFKDLLQSAKKKSIHIILDLTPNYQGQNAWFLPAQADIVATKMKEALSSWLQDGVDGFQFRDVGKLMNAPLYLAEWQNITKNLSEDRLLIAGTESSDLQQIVNILESTSDLLLTSSYLSNSTFTGERTESLVTRFLNATGSQWCSWSVSQAGLLADFIPDHLLRLYQLLLFTLPGTPVFSYGDELGLQGALPGQPAKAPLMPWNESSIFHIPRPVSLNMTVKGQNEDPGSLLTQFRRLSDLRGKERSLLHGDFHALSSSPDLFSYIRHWDQNERYLVVLNFRDSGRSARLGASNLPAGISLPASAKLLLSTDSARQSREEDTSLKLENLSLNPYEGLLLQFPFVA
The following text describes a protein:
Function:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MIVSQYLSALTFVLLLFKESRTWSYHASTEMMTFEEARDYCQKTYTALVAIQNQEEIEYLNSTFSYSPSYYWIGIRKINGTWTWIGTNKSLTKEATNWAPGEPNNKQSDEDCVEIYIKREKDSGKWNDEKCTKQKLALCYKAACNPTPCGSHGECVETINNYTCQCHPGFKGLKCEQVVTCPAQKHPEHGHLVCNPLGKFTYNSSCSISCAEGYLPSSTEATRCMSSGEWSTPLPKCNVVKCDALSNLDNGVVNCSPNHGSLPWNTTCTFECQEGYKLTGPQHLQCTSSGIWDNKQPTCKAVSCAAISHPQNGTVNCSHSVVGDFAFKSSCHFTCAEGFTLQGPTQVECTAQGQWTQRVPVCEVVRCSRLDVSGKLNMNCSGEPVLGTECTFACPERWTLNGSVVLTCGATGHWSGMLPTCEAPTVSQTPLAVGLSTAGVSLVTIPSFLFWLLKRLQKKAKKFSPASSCSSLKSNGCYSTPSKLI
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in assembling cut9 in the 20S APC/cyclosome.
Sequence:
MLRRNPTAIQITAEDVLAYDEEKLRQTLDSESTTEEALQKNEESTRLSPEKKKIIRERRIGITQIFDSSMHPSQGGAAQS
The following text describes a protein:
Function:
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.
Subcellular Localization:
Nucleus.
Sequence:
MATNESWVPYQFTTTNSVSRSAEPASSILAAQLAPHLVSQGNSAHGYLTRETFSQLRQELVDGKCSQLGLDDSIADASKLICIVLQAGIEPCVKGDRSRQGDFEGQILDCLDIIQTILEKSPQVLGEICDPTILGENTSISLYAWLTLRLLNLLSWEANNIGKRITSIFSSIIRPHYKHTTLLPFCYSALALLRACTNEIFLSLESHHNLLRQHMSEVRLSIPAVKSAIFLTLDNLNLPRALLSKKITLGTFPQTITLALRLLDSFVPKRAFHSHTSIKDPTLHQDLAWILNGIERLWRITHRWARTSMDDIEIKSRICMQFTSSLHIYRSLEPDISGLLSPQSGLARPWVQICNDLVTLSLIQMPHLQAELGRLLDELIDASQPRLEVVTQFRAALLPTMIDFKSKGTIQSFEPGFQAVLQILMGPMSGAESRSLVNLQEPNTAGQTGQQDEMLQHGTTHDIPRPQEGSARLDTAHKLISKIFELLGCGEPVNVECLSHAISESFVDLPDQKKSDLLYMLGRVACAMAGSLSSPSKAAPEISLSCSVCETEKRALGPEPASKPRDVHELCEIFTFILPRLTRASSLRVTAMDALRRLLVHAPPESCYLQLKSSVFGDFCLHSLRSSIRELRIVTGRLVISFVRKDINADTRRSNFVVILEWLRSLSEKQELPLHETCILTLCHIAEVSDDEEMNIILLRLLEYLGHPNPFICAVAYAELSKLAQRLSVTPAGLFRPFWRTLSITVVKNFQSRPHMAEQLCDLLGMNVDDFLRLTEVHILPYLVLTRKRDVITRVGAAYKHIKTPFDICSEKNNLAAILAFLMSQPWSDPEGMIMSVLSDIDSAFGGRTLAELALVIREVRKAHGHFHRALHLLAALVPRKSTATSKKANLLCHFIEEHVLGIITQFAHAINDFQIRQPLIEKRRNILAIGEMIKVARGHISSALPQICACLRSALSIEELSDHAFSAWSVLVSSLHEEELEPLIDQTFSIVIRYWDAFNYQSKKTAEELIGYILRSHSGLVHTNFSTIPSLASIPALSALESEISKMKEKMDVRSQLSAFGRRCQSENAAVVEQALRELLPCLSRHEEFLHESVLSEQPDPVVAQLTRSLLDCCVKFNAGSDSITLLSAQCLGLVGCLDPNRVDPVKDKKDILVLSNFDRMEETFDFVLFFLQHVLVQAFLSASNTRAQGFLAYAMQNLLRLCNLDSAVTQRSRDVQADEKYRRWSELPETVRNTLTPFLTSKYTVTVGAIRSRCKFPIFSTELTHGDWLRSFVQDLLQRGSGDNAQLIFSVCSRIVKGQDISIASFLLPFAVLNRIVGGTQEERLDLQSELTTILSHPLPEASNRVHEAIILCRQSVFEILDYLSRWLQGKKKLLHGLKNHASHTGRSHKDSHQDSLSETYSSQVKAVETFLGSIPPEVISKRAVECKSFSRALFHWEQYIRRFKSQSDKNDHTSTELLYQHLQVIYSQIDEPDGIEGISSHLHVLNIDQQVLQHRKAGRWVTAQSWYELQVEKEPDNIDAQWNLLTCLRESGQQDAIIARVDTLNSAGSTSRFLPFAVEASWITGNWDKLRSYLQMRSPENTGDFNIGVGSALCALRLGNKTEFRNIIHDLQLSVAKSLTVNSVTSLQSCHDSILKLHALTEMELISDCEGTENSSLTSIHDVLNRRLDVLGGYIADKQYLLGLRRATMELTHGFMESDIAGSWLTSARLSRKGNYTNQAYHSMLRAARLKDRSATIEHARLLWKDGHHRKAIQTLEGAIAANEFASDTSSSGGLKNEKQQNLIAARAHLLLAKWTDRAGQTQSDVIVQRYREAIKLHSRWEKAHYYLGKHYDKILESEKAKPLGKEAQIYLSGEASKLVIDNYLRSLAHGNKYVFQSLPRILTLWLEHAATVDKPFDPKRGDNEEFQTHTLNQRKKTLDDMHSQLKKYLNRMPAALVMVARICHPHATVYELLTRIVAKVANAFPQQGLWTVLAVVKSSSKDRASRGINCLHKITEANKKSRTEFPLDMRGMINQGQKFTEEMLKLCTARVEEKASRIHLARHLGFSHKVAPCRLVVPFQAMLTPSLPASHETEYLKGFRAFPRDPTTIDAVLDDAQVLSSLQKPRKISIRGSDGKIYNVLCKPKDDLRKDQRLMEFNNTINRFLKKDVESSKRRMYIKTYAVTPLNEECGLIEWVDNLRTLREIIIKLLKERGIMPNYNEIRHYLNEACSEASKLHLFTTKVLMKFPPVLHEWFVEMFPETGAWFAARLRYTRSCAVMSMVGYVLGLGDRHGENILFEEGTGGVIHVDFNCLFDKGLTFEKPELVPFRLTQNMIDAFGAYGYNGLFPKSLKDEAFAQLLFTGPFRRTCEISLRLLRQNEDALMTVLETFLHDPTTDFIGKKRRTHANVPETPAGVLENVRNKLRGLLPGESVPLSVDGHVDELITQATDKRNLAAMYIGWCAFF
The following text describes a protein:
Function:
May be involved in the O-acetylation of mannan. May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity).
Miscellaneous:
MISCELLANEOUS: Contains 2 motifs that are conserved in esterases, but it is unlikely that this protein belongs to the catalytically active pectin esterases.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MEQQLTLVLLDSPKGAKYVETFEEAASSSSSSSSSSVPSCTDHRHRTFVKFFLYFSLVALAYYFIISSLAVSPIPPTLPQSSPGNVSSAKCDLFTGDWIPDPTGPLYTNVTCRHIQDFQNCLLNGRPDVNYLFWRWKPRDCDLPRFSPSQFLASVKNKWWAFIGDSIARNHVQSLICILSQVEEVEEIYHDKEFRSKIWRFPSHNFTLSVIWSPFLLKSETSSNSDIQLYLDQLDHKWTVQYPKFDYVVISGGKWFLKTTIFHENNVVTGCHYCQGRNNLTDLGYDYSYRKTLNLLRDFVLNSTHKPLVLFRTTTPDHFENGEWNTGGYCNRTMPFKEGQANMKTVDDVMRDVELEVFQKFGKGFGLGSNIRLLDTTGMSLLRPDGHPGPYRHPNPFAGVKNKSNVQNDCLHWCLPGPIDSWNDVMVETTLNRERELYDLTG
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Sequence:
MAADLSAYPDRESELTHALAAMRSRLAAAAEAAGRNVGEIELLPITKFFPATDVAILFRLGCRSVGESREQEASAKMAELNRLLAAAELGHSGGVHWHMVGRIQRNKAGSLARWAHTAHSVDSSRLVTALDRAVVAALAEHRRGERLRVYVQVSLDGDGSRGGVDSTTPGAVDRICAQVQESEGLELVGLMGIPPLDWDPDEAFDRLQSEHNRVRAMFPHAIGLSAGMSNDLEVAVKHGSTCVRVGTALLGPRRLRSP
The following text describes a protein:
Function:
Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
Subcellular Localization:
Secreted.
Sequence:
FVPFFTQSDIQKMQEKERNKGQ
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTATETVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGTFVFRIEDTDAQRDSEESYLALLDALRWLGLDWDEGPEVGGPYGPYRQSQRAEIYRDVLARLLAAGEAYHAFSTPEEVEARHVAAGRNPKLGYDNFDRHLTDAQRAAYLAEGRQPVVRLRMPDDDLAWNDLVRGPVTFAAGSVPDFALTRASGDPLYTLVNPCDDALMKITHVLRGEDLLPSTPRQLALHQALIRIGVAERIPKFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWSIADDHDLFGLDEMVAAFDVADVNSSPARFDQKKADALNAEHIRMLDVGDFTVRLRDHLDTHGHHIALDEAAFAAAAELVQTRIVVLGDAWELLKFFNDDQYVIDPKAAAKELGPDGAAVLDAALAALTSVTDWTAPLIEAALKDALIEGLALKPRKAFSPIRVAATGTTVSPPLFESLELLGRDRSMQRLRAARQLVGHA
The following text describes a protein:
Function:
May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNNQTNWIKILSGFASDSKWKIMLSILLSIISVFSGLVPYWAVFKIILMMINNTYTINSIMVYIFIALIAYISQVCCFGASTMLSHITAYEILSEIRKKLAQKLMRLPLGVVESKKIGELKNIFVDKVETIELPLAHMIPEVIGNLLLSAAIFLYIMLIDWRMASALLVTIPISIFAFKKVMSGFNETYAEQMKSNNYMNSAIVEFIEGIEVIKTFNQSQSSYKKYKDAVDNYKIHTLNWFKNTWGYMNLGASVLPSTFLGILPVGMYLISINQLNYAEFFLCIVLSLGVVAPIKNFTNYVNHLKSIQYALTEVNQILSLEELVLSTKFKKPQHYEIAFNNVGFSYNKDKDDLVFKHLSFTVPENNFTAIVGASGSGKSTIAKLISRYWDVTSGEITIGGINIKDIESKQLNDLVGFVGQDNFLLNLTFKENIKLGNPEATDEAVEKAAKLAQCHEFIEKLPDGYDTNVGTVGDKLSGGEKQRVTIARMILKDAPIIVLDEATVYVDPDNEQKIQEALNVLTQDKTLIVIAHRLSTIQHADQIIVLGKQQILEKGSHHLLLKLNGNYKKMWDTHMHTKDWGINTGHN
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSATNQFTVLTISQFDSHNIIHLSFTIAFAQMIIIILLLFETPFRNPLVLRLDQFKIGKPQLAVKSFGATLFVAMMYNIYSVFELRRRFVDAVDSSNHILLAYHMFVAYLMGFSLFLLVTVNSLHRYIKEVVMVTEIIRATKKQNRAYENCMKKRAEEAETIRKDISRLKTDIINLESECSMKEQAVQLLRAESSTLKDRLEGCLVEYDRLLTYNKDLREQLQGVNGRSSHSDGIISAFFSWDRWGL
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Sequence:
MMDFLKRFFGSSQERILKRFQKLVEEVNACDEKFSSLSDDELRKKTPQLKQRYQDGESLDKLLPEAYGVVKNVCRRLAGTPVEVSGYHQQWDMVPYDVQILGAIAMHKGFITEMQTGEGKTLTAVMPLYLNALTGKPVHLVTVNDYLAQRDCEWVGSVLRWLGLTTGVLVSGSPPEKRKAIYQCDVVYGTASEFGFDYLRDNSIATRKEEQVGRGFYFAIIDEIDSVLIDEARTPLIISGPGEKHNPVYFELKDRVAELVYFQREMCNHIAIEARKVLDPFLGTDVLPKDKKVVEAISEACRALWLVSKGMPLNRVLRRVREHPDLRAMIDKWDVFYHAEQNKEQCLEKLSSLYIVVDEHNNDFELTDKGMLQWIEKIGGAAEDFVMMDMGHEYALIEEDATLSPADKLNRKIAVSEKDTQRKARAHGLRQLLRAHLLMEKDIDYIVRDDQIVIIDEHTGRPQSGRRFSEGLHQAIEAKEHVTIRKESQTFATVTLQNFFRLYEKLAGMTGTAITESREFKEIYSLYVLQVPTFKPCLRIDHNDAFYMTEREKYQAIVAEIISAHRSGKPILIGTESVEVSEKLSRILRQNRINHTVLNAKNHAQEAEIIAGAGKVGAVTVATNMAGRGTDIKLDEEAVAAGGLYVIGTSRHQSRRIDRQLRGRCARLGDPGAAKFFLSFEDRLMRLFASPKLNTLIRHFRPPEGEAMSDPMFDRLIETAQKRVEGRNYTIRKHTLEYDDVMNKQRQTIYAFRNDVLHAEDLFVVAKEQIEHVALALAFLILKDAHADHCSLPKIEEWLSYSFPVKLDDQEIRRLGDVDAVADYIGDLLIEAFDVKFSAMLAEFTEIIGSAANAQGICNDILRSVIISHIDEEWKVHLVDMDLLRSEVGLRSVGQKDPLIEFKNESFLLFEGLIRDIRIAIVKHLFALELSLTRSDRPDNAIPTVATAFHNHDNFRPMELTIVGEEEES
The following text describes a protein:
Function:
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.
Sequence:
MSDSGVVTVYGNGAALLEPKKSSTFSVKVGLAQMLRGGVIMDVVTPEQARVAEEAGACAVMALERVPADIRAQGGVARMSDPGLIKEIKRAVTIPVMAKARIGHFVEAQILEAIGVDYVDESEVLTPADDQHHINKHNFRVPFVCGCRDLGEALRRIREGAAMIRTKGEAGTGNIIEAVRHVRSVMGDIRALRNMDDDEVFTFAKRIAAPYDLVMQTKQLGRLPVVHFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDPARRARAIVQAVTHYSDPEILAEVSCGLGEAMVGINLNDAKVERFATRSE