lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQLPTGINSGVNSGAGTTTWAADGTKNELRRDACRSRSASWKRRPVGLRVRHCNRHCSSSSSEDHQVYRRTSAMVLLELDPFLNELTKLYENTKKSGTVWVTLKRSTLQRQKKRKKPEETPAQAAEAPEFRCLVRATDGKKKISCSLTAKDHQRFQTSYATVLKAHMDSLKKKEKNKKSSAAKAQAS
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MVSIHQLFVVFIGISVTVVTRGSSPPQRCHQVLEFYRQQNFNETLDVEVVNGKVCREPSCCTGKMERNLRLKVEEDLKAGVLRGGEQVGGELKAKHDNLDKFFIELIDQSKSQLDILFYETYGSLYIDNSEIFSFFFKELEEYYRGGPLMVEEISENFFTSLMLKVFQLLNKSYLLDDEYMACIGENVGRIRPFTDIPDRLSMQLQQAFVASRAFVRGLETGSDVIKKLSKISLSDECSSSLMRMKYCGRCGGTMAPECDGFCLNVVRGCLCSLQQVGGVWKKYIDTMDSLLEKLSGSFNIEIVLGSIDVQISEAIMTFQEHKVAITKTVFGICGKPKSNPNATLPTLTMSYPQPHGAEESYPVHYPSLYPGYQGPSSFEDLAGYGADPDNWIGDSPLSRKSRSTKKNRKRRGRKRSRDISMDQRGMLRPSSRYVEDK
The following text describes a protein:
Function:
Weak apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Weak inhibitor of caspase activity.
Subcellular Localization:
Cytoplasm.
Domain:
The BIR2 domain is required for caspase-inhibition; The C-terminal region containing the RING finger domain is required for the initial degradation step, and the final digestion of cleavage fragments.
Sequence:
MSRWSVSQGCGNSHKALTMAGHGEQLFRGWGMVRPSMRSEAERLRSFSAWPRTCPQPSPVEMARSGFYYLGPGDRVQCFSCGGVLRSWEPGDRPDTEHRKFFPSCTFLQQQQRDPGATDSQILGQHSGEEPDRTWESVYPEMAEERDRLDSFRNWPMYAHGNPEHLAGSGFFYTGHRDNVKCFHCDGGLRNWEQGDDPWTEHAKWFPMCDFLLHVKGEAFIRRVQESLFRSPESSPDSLGSYIYDRSPASSPGSPESWRYLQSSVAQDALQMGFKQSLVASLIQSKFLLTGSSYSSVSDLVTDLLVAEEETHSTESVSVSRAPTRMERSEPPKESAPPLSTEEQLRRLKEERMCKVCMDKDVSMLFVPCGHLVVCTECAPNLRHCPICRAAIRGSVRAFMS
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MKSLDPDLQGETLRLTHSTLNSQDEMTASGKTHSQDQCASSDYVHDERYGREMQVQIKPALFSLQNEVAHSTGFSAFGYSDPYISGLYTAYGPQPYPHMMGIAPARVPLPIDMAEDGPIYVNAKQYHGILRRRQIRAKLEAQNKLVKNRKYEKFHHIDQYGRRNMQIVSYRDLTKGKKLTAYDLLPVGGGRTLVALHFQVLGLTLCATRAVNRVRGSGGRFLSSKKVHQSDPNSYPTNSTSSLDSVEHEGSTSAFSSVRQDVVHNGINFQQQPDHMAFSVSSHMVITMQGNGSQQRAPVVR
The following text describes a protein:
Function:
Has a role in meiotic chromosome segregation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGFATILYSIWVVLSSFVILSAYQLEVRKFLVKLLSKIVIGASESNVASFFAFVSEKSLEAASVKFVATIIAERMGAQFSSFYDKIFFVDMLGLGSLFALAAVNVLAARKLESELPASLEPSIGNRDQQKNSSLAKCFSRLFINDLHGTTVKRYPYISYLPNWLLAKNNAERLVYKSHLLLNAYSPPKSASASSVIVWVCGAKKSESIIIPYLSSLGFFVVVPNYAQPPKFPLSDAVEFVSLCVDWIVENAIYYDADPERIFFLGEDTGASVALESLKHIRPNSVKGIFALCPRSIQNLVWTNQSTIPMMTLHAGDVNPVSDSNDRESSEKASLIKNFVVPGAVPYYYEFTSPRTISTATFIARWFFLVEDNKKTI
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Sequence:
MATIVRQNGLTPIQETNEVKSFLKERGIDYDHWKVPHNASNLTDKEVLVDTEKEELLKKLDDRFETLKAKEGYQSRDLIVLHPNVSGLNEMLAKFDKVHYHTDEEVRYIVDGSGVFGFAFKDEKFLVHVYKDDFISVPRNTNHWFYLDDKKRIKAVRYFQDMSGWVPNYVEETNSLD
The following text describes a protein:
Function:
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
METEKATKRLYVGGLSQTISQADLQHQFSRFGDVSDVEMITRKDDQGNPTKTFAYVNIKTTDLEFKRCMSLLNKTKWKGGTLQIELAKESFLHRLAQERQEAKVKKEKPLRVQHADRLESLRKAGVVDFHMKAVPGTEIPDNKDWVVSKFGRVLPVLHLRSQTRRKIIKYDPSNYCHNLKRLEQAFTDTVPIGSLTWQLEGGDDPMSKKRRGEFPVFHNRYQKKARIRGNKDINGVPAQGPDLLVTNQNLIREKSIQKTHFTSNGLPKLLQIPNNNKSEERFLQTSAPEPVEKVNSMSDEDFDSEEEFRAAVAREKTLRRGTPDAEPEDDPLEIVSEHFELKLSTHWSLTNSDIKKNAFCGGKGEGDDDDNSDCDSADTDEIIATKKPPSKSRDSQDYSKSKSKPGPEERIVSKEMPKPKASGSLSVGKVKSPHFKGQSDNTESQSDSTGSESDSDTSDSDGDMDYEAMMRNCYHLDLTLEDLEKLAGGDLESSGEGTQSKPSGTTKRGVKVDGERNGRASTPVRKPTRCINPEDIVASILEGEEDVSDDRVPKRSTAESKFQAFKGIGSLYRDKTLEKHQRETAASSERKKELTSASPAPSGTVVPEEDGSSSPDLSWDGETADGRPQVVTEARSVKGTRVGPGKLQKRKTSSASKAPSLESADSRSPPFGGIKSTSARPGTPGTGLRDEDDGSHNQPGLPGSEEDSSAARPSVTPSVQQSQKVTIPKTPVKKLVKDSIEKGSTASAVLSHGTKAEPLKSTADFILPVNTVHGAEAKDQHLQDNQKRLAAIQERQREREMQKKLIRGALSSLDGQVESKSTHIIFNSDGESEAEEKLSNEECEWTKEKKREFKSRTSGKLFESSEDEGDESEDDGDRFKIKPQFEGKAGQKLMNLQSRFGTDDRFRMDSKFLESDSEAEDAEEVKKETTAEEEELAEEKKKNLDVLQSILHIDLQTPKLSKQASAAREFKDMNSMRYDPTRPDHVAFEKKVNGASKESKAKRKKNRIEAEKLPEVSKEIYYDVAVDLKDLFGSTKCSVEQPEKIPWDRSEVEDSIEADPKPLAQNNVEEESAGFTFSFFGPDTEEVKESKEESYKVEMIKPGKVVWQEDPRFQDSSSEEEEQEEEEEQQLEEVDGGRPSLGLPSLPERQTVRFFFFSRDDERLREGCELFWRKSVHQESRDAWEARSSALLVECRKKHKDARRKVKGKH
The following text describes a protein:
Function:
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation.
Sequence:
MASSQAALLLQKQLKDLNRTPVEGFSAGLIDENNVFEWSISIQGPENTLFDGGLFNATMIFPIDYPNSPPTVKFITDIWHPNVYLDGRVCISILHPPGDDPLFYELASERWTPVHTVESIMLSIISMLSSPNDESPANVDAAQEWRDNRAEFVKKEVVLDTLMEFVKVGNGGKFHSAIYHRLLDRIVHSSLDVHDVLLDLLSSKYFKYIDIRYFTYISFKKLSQSIGAKDISDDRREGLDTSSVNKPESSLDLSVHKLYYLLSRIPPLEGSDVKSKYDMWKAAGIFTGKENEKEHTGKQCKDESTNIKVLSPANIAKKMKLRFTKAWISFLGLPLPVDLYKEVLVNLHQVVIPYLSNSLMLCDFLTRSYDIGGVVSVMALSSLFVLMTQHGLDYPNFYEKLYALLEPSIFMAKHRARFFQLLDSCLKSPLLPAYLAASFCKKLSRLSLAVPPSGALVIVALIHNLLRRHPSINCLVHQEGGSETTTDIKSAESSGADDSNNVSSPSRLKSSMKTGIDPFDDKQTDPLKTNAMRSSLWEVDTLRHHYCPPVSRQVYHMIIGSPVSMGIYVRAKTTEVAVKDFSSGPYATIFGDEIRKRVKQAPLAFYTATPTLLFSESDFLGWTFKLKEDKDSTVVLDNISKEKGHFSAKQSRGESELS
The following text describes a protein:
Function:
Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.
Subcellular Localization:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
Sequence:
MTENNEKENEPQNRDLQRSPGTVSVQPESKLQRLKRSLSFKSMMRSKSVENFFQRSNSEIKFPSDLITAPPPSPPLPMETPPLIYGDPSLSPTPSLSPNPSQSPTSSLSPSPSLSTKPSAQLRPLKTHFFQEHVFRRPTYCQLCKHMIVGNSKQGLRCKACKLGAHLWCSSELSQQQCNGKSGAFKRNFSSPLLVNDQLGVVKEAPPSAVKNRIDPVYETLRYGTSLAQMSRSSFGSVSESPTRSMSERSEGAEDGEDSQRSTEEEGIQGPGESEKAGSEDRVSLKAPARIEVSHMHTYVVLYKFVPQEQNDLELHPGDRVQVTDDSNEDWWKGKSADKVGFFPANFVQRVRPGERVWRVTQPFHGNRELGQMTVKESQICVGKNEEVNGFLKLTSGKKRGLVPYDSLDEI
The following text describes a protein:
Function:
A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
Subcellular Localization:
Cytoplasm. Note=Binds to ribosomes.
Sequence:
MPFRNVAIVAHVDHGKTTLVDAMLRQSGALRERGELQERVMDTGDLEREKGITILAKNTAVHRHHPDGTVTVINVIDTPGHADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKALAAHLPVILVVNKTDRPDARIAEVVDASHDLLLDVASDLDDEAAAAAEHALGLPTLYASGRAGVASTTAPPDGQVPDGTNLDPLFEVLEKHVPPPKGEPDAPLQALVTNLDASTFLGRLALIRIYNGRIRKGQQVAWIRQVDGQQTVTTAKITELLATEGVERKPTDAAVAGDIVAVAGLPEIMIGDTLAASANPVALPRITVDEPAISVTIGTNTSPLAGKVGGHKLTARMVRSRLDAELVGNVSIRVVDIGAPDAWEVQGRGELALAVLVEQMRREGFELTVGKPQVVTKTIDGTLHEPFESMTVDCPEEYIGAVTQLMAARKGRMVEMANHTTGWVRMDFVVPSRGLIGWRTDFLTETRGSGVGHAVFDGYRPWAGEIRARHTGSLVSDRAGAITPFALLQLADRGQFFVEPGQQTYEGMVVGINPRPEDLDINVTREKKLTNMRSSTADVIETLAKPLQLDLERAMELCAPDECVEVTPEIVRIRKVELAAAARARSRARTKARG
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore.
Sequence:
MVEHKLDASTISKMIPQIFDQMRRQTGSKNFASTPASISTQSLLKEQEQLDKIIPVIQNLNERIKDCKEGDMERIKETCHAMNTILDKFISIQSQASYVNSMMNNEEYLDYVASGKSEEEYISAKQREVEELEKRVKQYTTMHAPSVKPPASKIPVGNDTRKVTKPGQRNGRSGLYSISTRNNSNNSGANGRRPPGNGNNVGRRRVYR
The following text describes a protein:
Function:
Chaperone that functions as a gatekeeper on the periplasmic side of the SecYEG translocon. Facilitates the translocation of precursor proteins across SecYEG by interacting with the translocating substrate. Also plays a role in the release of newly synthesized secreted proteins at the periplasmic exit site of the Sec translocon. May be involved in the early periplasmic folding of many newly translocated proteins. Acts as a transient subunit of the Sec translocon that binds to the lateral gate of SecY and is detached by nascent membrane proteins but not by SecA; Does not have peptidyl-prolyl isomerase (PPIase) activity. PPIase activity could not be generated by substitutions at the peptide binding site of the isolated parvulin-like domain; (Microbial infection) May play an important role in bacteriophage T4 infection and be involved in the penetration of the inner membrane by the bacteriophage injection machinery, resulting in a DNA-conducting channel to translocate the phage DNA into the interior of the cell.
Miscellaneous:
MISCELLANEOUS: Overexpression restores viability of surA skp double deletion mutant but it does not completely compensate for the growth defect caused by the simultaneous lack of the SurA and Skp chaperones. Suppression of surA skp lethality does not require the parvulin domain but the membrane-localization of PpiD. In the absence of both SurA and Skp, overproduction of PpiD can, at least in part, counteract the defects in the biogenesis of OmpA and possibly of other OMPs.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side. Note=Located at the lateral gate of SecY.
Domain:
Consists of an N-terminal helix that anchors PpiD in the inner membrane, followed by three domains that face the periplasm. The first or the third domain are probably chaperone domains. The second domain is a parvulin-like domain, which is devoid of catalytic activity. It shows a parvulin fold and resembles most closely the inactive first parvulin domain of SurA, which is part of the chaperone unit of this protein and presumably involved in substrate recognition.
Sequence:
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQEISRGQFENAFNSERNRMQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQAIFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQLTTQQLINGVAGTDFMLKGETDELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDAATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAKEKSADIISARNGGDMGWLEDATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAKVKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTESLAGAEQAAGVKATQTGWFSKDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLADVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPISQAAFALPLPAKDKPSYGMATDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNIAKQQQAFLGIDYGKKRIGLAFASSPLLIPLPIGNVEARSSLTLTAQALVSIIKERAVTTVVFGNPLPMQKAYASSVQSEIQELAALIQEMTAIEVILWDERLSSAQAERMLKSDCGLNRKQRKNPSDSLAATLILSSFLDSRKLY
The following text describes a protein:
Function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Sequence:
MAGDKQGDKQAETTSVPAEARERHAQLAEQIEEHRFRYYVNDAPVVSDAEFDRLLRTLEELEERHPELRTPESPTQKVAGAYATEFTAVQHPTRMLSLDNTFNDDELAAWFERIARELGEQEYHFLCELKVDGLAVNLTYERGRLVRAATRGDGRTGEDITPNVRTIAEIPDRLAGDKVPDLVEIRGEVYFPMEKFQELNARLNEAGDKPFANARNAAAGSLRQKDPRVTASRPLHMVVHGIGTLEGYSGLTRLSQAYDLLKAWGLPTSPHNRVVDGLDGVREFIAYYGENRHSVAHEIDGVVVKVDEIRLQGRLGSTARAPRWAIAYKYAPEEVNTKLVDIKVGVGRTGRVTPYAQVEPVTVAGSEVEFATLHNQEVVKAKGVLIGDTVVLRKAGDVIPEILGPVADLRDGSEREFVMPAECPECGTPLKAMKEGDIDLRCPNARACPAQLRERVAYLAGRECLDIEHFGGVVAAALTGPLEPSEPPLVDEGDLFDLTVEKLLPIKAYVLDPDSGLPKRDPKTGEEKIATVFANKEGEPKKNTLALLQHIEEAKTRPLARFINGLSIRYVGPVAAQALAREFRSIDRIEQATEEELASTDGVGGAIATAVKEWFAVDWHREIVRKWKAAGVPLEDRSTGEDEGPRPLEGLTVVVTGTLENFTRDGAKEALQSRGAKVTGSVSKKTSFVVVGDNPGSKYDKAMQLKVPVLNEDGFAVLLEQGPEAAADVALSAEE
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MDSTAVRRARGGGVWEGLYRLLMRRNSVYVTFVVAGAFVGERVVDYGVHKLWDYNNAGKKYEDIPVLGQRQSE
The following text describes a protein:
Function:
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MNSLLLFALFSLCLADSYDHTYTDLEHHRTIYISENGPRLSVVMEQSKVISRRGGNATLPCKFVRDAGSATGPSQRMRIKWTKLTSDYLKEIDVFVSMGYHRKSYGSYHGRVFLQQATDNDASLVITDITLDDYGKYKCEVIEGLEDDIGVVALDLQGIVFPYFPRLGRYNLNFLDAEKACQDQDARVASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITNPREPCGGKDTVPGVRNYGFRDREKSQYDVFCFTSNYKGRFYYLIHPSKLTYDEAVQACQKDGAQIAKVGQMYAAWKLMGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFKAFN
The following text describes a protein:
Function:
Inhibits the intrinsic blood coagulation pathway by blocking the activation of host coagulation factor XII (F12) but not the enzymatic activity of activated F12.
Subcellular Localization:
Secreted.
Sequence:
MKTIIVVTIFGILTCAYPTDGEHCAQEKAMEDFDPSRFFNGKWYVVHYGKTGPTVCQKFSTNGTQGAPTQIVETGYDKFEDYLKFQCDETGKKNDYHYSFKCKSYECGSDNIEFEVDFTVLSASYDDFALVCRTITFTSGTKDKDDEVLVLEREKTLDVIDNCRRTYYLTEFEKMSLSSQFLSKKENITMLSFQLK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSIPNSQMELPSVAQHECPECGKRFLKKNKLIIHFRVHTGEKPFMCTECGKNFRRKQYLTEHQLIHTGEKPFVCTECGKNFSRKHYLTEHQLIHTGEKPFVCMECGKSFRVKHILTDHQRLHTGAKPYACTECDKQFNKRSSLLGHQRIHTGVKPFVCMECGKSFSDKSTFQKHQRIHTGEKPFSCTECGKCFTTKSQLTRHYKVHTGEKPFSCTECGKCFLTKTKLSSHYMVHTGEKPFACADCGKCFTKKSQLSSHYKVHTGEKPFVCADCGKSFISKGNLTKHQRIHV
The following text describes a protein:
Function:
Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
Subcellular Localization:
Membrane; Single-pass membrane protein. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm.
Sequence:
MPDVKESVPPKYPGDSEGRSCKPETSGPPQEDKSGSEDPPPFLSVTGLTETVNEVSKLSNKIGMNCDYYMEEKVLPPSSLEGKVKETVHNAFWDHLKEQLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRIEIEEALDMDLLKQEAEHGALKVLYLSKYVLNMMALLCAPVRDEAVQKLENITDPVWLLRGIFQVLGRMKMDMVNYTIQSLQPHLQEHSIQYERAKFQELLNKQPSLLNHTTKWLTQAAGDLTMSPPTCPDTSDSSSVAGPSPNEAANNPEPLSPTMVLCQGFLNLLLWDLENEEFPETLLMDRTRLQELKSQLHQLTVMASVLLVASSFSGSVLFGSPQFVDKLKRITKSLLEDFHSRPEEAILTVSEQVSQEIHQSLKNMGLVALSSDNTASLMGQLQNIAKKENCVCSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVNLTHHNQQVFGPYYTEILKTLISPAQALETKVESV
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAAARIAPQSAAVAAPAPATTAASAIAKAPSADVQSELDRAALEALELDSDVITSVRLDGLALTKIVKHCRDAHPASASGALLGMDLGGTLEISNVFALPNPGRSNSERDEEEDRSSRNATRYTSDMVRLLRDVNADANPVGLYQGCFLGAFLNSSVIDGLAAITGLVERDGAGSRGKGVLIVHDLAQSAQGNTSVKAYRLSPSFVDAHKKGKFHTQSLIDHKLTFSNILIEIPVSLRNTALLDAFLSSISTPSAPGPSIVQPSTSDLLRNPPSAALAPSYTSLNLALEPVLASSLESTLEIMDEHAAEAGNVGFQARQLAREKAKADAYLARKKAENAAREAQGLAPLPIEDVNRLFKIPAEPSRLEATLLLGQIDSSARRLAETAALGVIQLNAAKTGAV
The following text describes a protein:
Function:
Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.
Subcellular Localization:
Secreted.
Sequence:
MAQPLDFLLVSICLFHSLFSFQVEDYYAPTIESLIRNPETEDGACVFPFLYRSEIFYDCVNFNLKHKWCSLNKTYQGYWKYCALSDYAPCAFPFWYRHMIYWDCTEDGEVFGKKWCSLTPNYNKDQVWKYCIE
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEKKIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGYVCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFTGNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQVLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEITALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQTLKEMSERTKSLGVPDAAARLYSVLEELKK
The following text describes a protein:
Function:
Catalytic subunit of the error prone DNA polymerase zeta. Involved in damage-tolerance mechanisms through translesion DNA synthesis.
Subcellular Localization:
Nucleus.
Domain:
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
Sequence:
MADSQSGSNVFSLRIVSIDYYMASPIPGYNICYSSFQGSEVNEVPVIRIYGSTPAGQKTCLHIHRALPYLYIPCSEIPLEHHKGVDGSTLALSLELEKALKLKGNAASKRQHIHDCEIVRAKKFYGYHSTEEAFVKIYLSYHPPDVARAASLLLAGAVLGKSLQPYESHIPFILQFLVDYNLYGMGHVHISKMKFRSPVPHHFRPRRFDLDDCPGQRIDEVAITKANSSAAASVSFPVWSLSTIPGQWMWNLSEESDTPLSQSQHRHQHHYRRQSLCELEGDATSSDILNQQFKMYNSLSQAQSDTNMVQSLVAIWEEEYERTGVHDAPIPPDPGKPSAADVLQTMSDYVGFGNMLKEMLNKVELSPPGMKPTAVSSAGPDMHAKPEITDLQALNHMVGTCSEFPASEQLSPLGEKSEEASMENDEYMKTPTDRDTPAQIQDAEALGLFKWFASSQAAEDINSDDEILRETILSPLLPLASINKVLEMASTDYVSQSQKECQDILDSQENLPDFGSSTKRALPSNPDSQNLRTSSDKQSLEIEVASDVPDSSTSNGASENSFRRYRKSDLHTSEVMEYKNRSFSKSNKPSNSVWGPLPFTLTKNLQKDFDSTNASDKLGLTKISSYPMNEMTDNYIVPVKEHQADVCNTIDRNVLAGCSLRDLMRKKRLCHGESPVSQHMKSRKVRDSRHGEKNECTLRCEAKKQGPALSAEFSEFVCGDTPNLSPIDSGNCECNISTESSELHSVDRCSAKETASQNSDEVLRNLSSTTVPFGKDPQTVESGTLVSSNIHVGIEIDSVQKSGREQESTANETDETGRLICLTLSKKPPSLDCLSAGLQDSAHSHEIHAREKQHDEYEGNSNDIPFFPLEDNKEEKKHFFQGTSLGIPLHHLNDGSNLYLLTPAFSPPSVDSVLQWISNDKGDSNIDSEKQPLRDNHNDRGASFTDLASASNVVSVSEHVEQHNNLFVNSESNAYTESEIDLKPKGTFLNLNLQASVSQELSQISGPDGKSGPTPLSQMGFRDPASMGAGQQLTILSIEVHAESRGDLRPDPRFDSVNVIALVVQNDDSFVAEVFVLLFSPDSIDQRNVDGLSGCKLSVFLEERQLFRYFIETLCKWDPDVLLGWDIQGGSIGFLAERAAQLGIRFLNNISRTPSPTTTNNSDNKRKLGNNLLPDPLVANPAQVEEVVIEDEWGRTHASGVHVGGRIVLNAWRLIRGEVKLNMYTIEAVSEAVLRQKVPSIPYKVLTEWFSSGPAGARYRCIEYVIRRANLNLEIMSQLDMINRTSELARVFGIDFFSVLSRGSQYRVESMLLRLAHTQNYLAISPGNQQVASQPAMECVPLVMEPESAFYDDPVIVLDFQSLYPSMIIAYNLCFSTCLGKLAHLKMNTLGVSSYSLDLDVLQDLNQILQTPNSVMYVPPEVRRGILPRLLEEILSTRIMVKKAMKKLTPSEAVLHRIFNARQLALKLIANVTYGYTAAGFSGRMPCAELADSIVQCGRSTLEKAISFVNANDNWNARVVYGDTDSMFVLLKGRTVKEAFVVGQEIASAITEMNPHPVTLKMEKVYHPCFLLTKKRYVGYSYESPNQREPIFDAKGIETVRRDTCEAVAKTMEQSLRLFFEQKNISKVKSYLYRQWKRILSGRVSLQDFIFAKEVRLGTYSTRDSSLLPPAAIVATKSMKADPRTEPRYAERVPYVVIHGEPGARLVDMVVDPLVLLDVDTPYRLNDLYYINKQIIPALQRVFGLVGADLNQWFLEMPRLTRSSLGQRPLNSKNSHKTRIDYFYLSKHCILCGEVVQESAQLCNRCLQNKSAAAATIVWKTSKLEREMQHLATICRHCGGGDWVVQSGVKCNSLACSVFYERRKVQKELRGLSSIATESELYPKCMAEWF
The following text describes a protein:
Function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MASFEEAPPGNSKNGEKIFKTKCAQCHTVDKGAGHKQGPNLNGLFGRQSGTTPGYSYSTANKNMAVIWEEKTLYDYLLNPKKYIPGTKMVFPGLKKPQERADLIAYLKESTA
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of malate to oxaloacetate.
Sequence:
MSDVANVVITGAAGQIAYSLIFNVCKGDMFGPEQKVKLFLLDIPQMVESLKGVLMEIQDGAYPLVTDVVCTADIKEAFTGANYVILVGAMPRKDGMERADLLKANASIFKVQGKAINDYANKNVKVLVVGNPANTNCLIAMHYAPDIAKENFTCLTRLDHNRAKSQIALKAGVNVKDVHNVIIWGNHSSTQYPDYRCGYINLPGGKQPIGNVISDEKWLQGEFISTVQKRGAAVIAARKFSSAASAAKAITDHMRDWVLGTPEGEYVSMGVPSDGSYGIESGIIFSYPVKCQNGKYTIIQGLSIDNFSKDKIEITRKELVEEKEAAFKFVGDN
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTKRKSALSALKPTKKQVISSEDSDPEVVVVTNPPLDSPDAEESFISITEEDEAVRQLSTFDFSAKNTKVVRDETRGRSRVFHGMKFKETIVLRGAYVVTVWSGVIHINGALVNINSPVDIPVFAPASHALPQIEAAAGAPETRESGDEDVMEALHQLEGSSVIVEIAAMPRRSENPLITVSNFGKMSSGNIVPFVRQLWHCSEDDGSNYSRIYNTASVVTKSQAAVIPGIYDEWAEVCDDIRRLKHSSTMVVGSQNTGKSTFCKYLSAFMTTKKTGTSVAFVDLDPSNCEFTAPGQVSVTVIGAGHLSPYSILGPSFTHVTAPTYSRFVGYNNPKDDTRGYIEACKAVIDFAKGLKLPLVFNTCGWVRAAGHDLLRQLIDHVKPSDVVFTRDPGVDADQARLAESVKARSHVLDAPDAEPPRFTGAEQHSLQTVTYLHGGNLASHLSDLPALEVGLESVYVGILDSEGVDLADVALSTNSTLLAVMTMDKKTVKHAEITPDGLQYLPNFDIPQGECLGQAMVQFAGASVRLHTPVSASLLNAQLAADKAIVLVRGRIPLPVYELWDSRKGGEQAYVSFDVNSGVGSEAWVARRGLKRK