lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Placenta-specific zinc-finger RNA-binding protein that destabilizes cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Binds to the 3'-UTR ARE of placental target mRNAs, such as TNF, HBEGF and LIPG. Involved in placental expression of many genes important for normal placental physiology.
Miscellaneous:
MISCELLANEOUS: Rodent-specific retrogene derived apparently from its related family member ZFP36L2 mRNA.
Subcellular Localization:
Cytoplasm. Membrane; Multi-pass membrane protein. Note=Localizes exlusively in the cytoplasm. Not detected in the nucleus despite the presence of a nuclear localization signal (NLS) in the zinc finger regions; a C-terminal alanine-rich repeat domain is able to override the activity of the nuclear localization signal and prevent import into the nucleus.
Domain:
Contains long series of C-terminal alanine-rich repeats that serve to maintain the protein in the cytoplasm.
Sequence:
MANNNLNRPLNTNVADSSNSSSTPGTAPPPSSSDPQVLGHQAPSSSASSLTEDCSSSFARDLNSYNNGQSGATGAVSWEAPHEPSEANAVSQIHPRNGEHSLQQKPKPQKVSGSSSLATSERYKTELCRPFEESGICKYGHKCQFAHGYRELRTLSRHPKYKTEPCRTFHSVGFCPYGTRCHFIHNQPEQQPVLSESTLEEPSSFNGSNVLHLGVNGEQQPGLQSDSPSGFLSVNSQALQAPLQLNQQALSSGGVMPSSHPAAANLRMMCCRTSSSTTAHDADKDPDKDADKDPSNNSANDALAFPQEPGDFSPVAFQNPNTATTTPTAFYNNQQQMGLAASAQFQMPLARPLPSATIFGQASVGPALTPGAAMAPGAALAPAAALTPAAALAPGAAMALGAAMATGAAMATGAALTPGAALALGAAMAAGAALAPGAAMAPGAAMATGAALAFGAAMATGTTLTPGAAMALGAAMATGAALAPGAAVAPRAALAPRAAFAPGAAALAPRAALPPGAALTPGAALAPGAALAPRAALPPGATLRPGAALIPRAALAPGAALAPGAALTPGAALAPGATLAPRAALAPGAALAPRITITSRAAITPGVAIAPGVATASTGILAPGAATATVGNTSSTTITAATAAEGAAPHFTFQLPDVESESESESLEFDVVTSTLDSLLVSDDEDEDDFLRRSSSSSSLNESEFDNTNSSRRLPIFSRFSDSEK
The following text describes a protein:
Function:
May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MTFLQVTIKMVAREASGHSYLVACWQPILILMLGTVLSGSATGCPSRCECSAQERSVVCHRRKLITLPEGIPIDTRLLDLSKNRLKAINPEEFLNYPQLEDLQLNENIISVIEPGAFSNLLGLRTLGLRNNNLKLIQLGVFTGLSNLTRLDISENKIVILLDYMFQELYNLKELEVGDNDLVFISHRAFHGLSSLEQLTMERCNLTSVPTEAFSHLHNLLTLKLRHLNVNVIRDFSFRRLYRLKILEIANWPLLESLTAKSLHGLNITTLSITNCNLTAVPYVAIQHLVYLRFFNLSFNPIEVVEGNKMHNLLRLQAFHLVGGRLVSIEPYSFKGLNYLRVLNVSSNSLSTLEESAFHSVGNLETLALHDNPLACDCRLLWVFRRRWRLNFNRQQPSCETPEFLQGKEFKDFPDVLPPNYFTCQKSKIRDHKAIHRFVDEGTTVQFPCQADGDPTPMIMWQSPKKQFITTKSIGRLSVSLDGTLEVRYAQIQDNGTYTCFAVNAGGNDTRLAHLHVHSYSPNWPHQPNKTFAFILNQPSDNSANGTGAMDPFPFDMKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNAKPNIEIEYVPRKVDGENSPNEGSHKISMKMI
The following text describes a protein:
Function:
Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNPIPSWPGRGRVTLVLLAVVPVALAYPWQSTRDYVLLGVAAAVVIGLFGFWRGLYFTTIARRGLAILRRRRRIAEPATCTRTTVLVWVGPPASDTNVLPLTLIARYLDRYGIRADTIRITSRVTASGDCRTWVGLTVVADDNLAALQARSARIPLQETAQVAARRLADHLREIGWEAGTAAPDEIPALVAADSRETWRGMRHTDSDYVAAYRVSANAELPDTLPAIRSRPAQETWIALEIAYAAGSSTRYTVAAACALRTDWRPGGTAPVAGLLPQHGNHVPALTALDPRSTRRLDGHTDAPADLLTRLHWPTPTAGAHRAPLTNAVSRT
The following text describes a protein:
Function:
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Miscellaneous:
MISCELLANEOUS: This chain binds calcium.
Sequence:
MSSKKAKTKTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLEAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
The following text describes a protein:
Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAAAAAAAAAAAAARKRSSSGGSGNGSNGSSSSSSIIISSPPGEQTTTTKKKKKQHRTELVPKPQIKKAVETLLKHPGIQKNNLLLSDYENIFLMVVLWKIPQVRKKIGIPLPFSIRHDTVEVCLFTRDEPKLTAEQTENHYRKLLGQQNVNISQVIPFKTLKTEYKPFEAKRRLLNSFSVFLCDDRIKRLLPSHLGKHFYLRKKDPLPVNMTCANLAQQLQKVIQGTSMAISNRGGCSSVQVGHTGMKIKEIVANVISTVEVLSEKLPEKWKNVKMIYMKTERSVSLPIFSSFLNEFKDLPRPAFAKPKKQKETQGEMKAEKIKASKKPAPRPEVKKQRSAGPGAGVPSVAGLEKEQKEKAKTTAVQEQEPEEEIPQLIPIQIGPSKKTPRKAKPEEKWPKKSLGVQSPQSQSTRQKRKVSVTELSPKEMNQGTEWLDGPAKRLRISEVTKQETPLSLRKATRKKTPRKPESSSSAAPDESPGKKPRISEVAEQETPSSLRKATPKKTPKKPEASFFVTPHKNPGKKARILEVAEQEILSSLSKATPKVTPKKPEASSSATPDESPGKTPRISEVAEQETPSSLGKATRRRTPRKPEASFFVTPHKRPGKKATISEVAEQETPSSLRKATPKKTPRKPEARSFATPNKGGRLMKSARKPPRTPKQNPKKPQVPQSA
The following text describes a protein:
Function:
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of small RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MGVSSFYPPLHVQRRRKLFKILQGGFPVRSLLDIGCGDARFLSYLVPCNDQVPIEFLAGIDINEQSIERATEALQVRTEDFLQLRWRPLHIELLLGNIKDFTHYKHVDAVVASEFIEHCQVAEILAFEKLVFGNLKPNVCVVSTPNFEFNTIFEKLSTLTSSISSRTSTNFRHPEHVFEWDRKEFAKWAYKICKRYPEYTVEFTGCGLLNDLIDGDDLLHFRPSSTYGFCTQIAVFHQSKNNAASHCFLKDQNSSILLYKKITYPFMEQLFPPTVQQFMNLLKKAFFDHLFGRHCLLLFQVIAGKCALSVKLPFLFIWESSPLIRHAFHYDDSIYLSYCPELKKSKHKGIALANSFSFRIAKVLKKSRIFIITFHHYV
The following text describes a protein:
Function:
Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Can translocate uridine, but not orotate, across a lipid membrane. Involved in maintenance of mitochondrial ultrastructure. May be involved in mitochondrial DNA (mtDNA) maintenance but does not appear to be directly involved in mitochondrial deoxynucleoside triphosphate (dNTP) pool homeostasis. May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKRLKAYLKDGINVAAVMCLGDTISQFFFDKKSLDEWDAGRTLRFGIVGLVFVGPTLRRWYHFLESRVPKTYSPMRRGVTKMLVDQTLFAPPFTMAMSFLVPLSNGEPIDRIRQRILDSYLSILVRNYMLWPAAQMLNFRFVPLGYQVLYAQFIALVWNCYLSMILNS
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MLLGLLVLSLAFQGTVIAATDCEECKTIVDLLQFEWGEKKTEECVMEIAVFICENFHIEDNDVCNFIISDFSDEFMYVVSKVVSLHISYCGDFVDPLAEIWNMTIPGNQPAYVPKNVVPTGNPTLRALHLTDLHVDMFYTPGLEAQCETPQCCRPQDMNVEIVENGAVKQAAGPWGTVGSCDTPYWLLTNMLEHIASSAGPIDYVMVSGDLVSHTVWAYTPETHSFMVKNLSDTIRSYFPTTPVYFAVGNHEGVPVDNIAPHFTPKKYHMDWLYKTMSNAWQGWIPADQEKTLEYNGCYMKKIYDGLRLISLNNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALNYYKIINRFTNTVVGQFFGHTHSEKFYMMYENPDDYKSTPNNVVYSAPSVTPYSDFFPAYRIYTIDGVYKGSTYQVIDYEEWFFNLTSNNANPKNVVWEQLYKSANAEYGLKGQTPDEYNQMIERMKTDTTLFNKYYENHYRRSQYDGLHPCDTQDCRNGYLCDARQFHQTNKLCTDLEGQGKIQKPDAKKKKYSARFVTEKSKRRGKEECKI
The following text describes a protein:
Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Subcellular Localization:
Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
Sequence:
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSEADKAKVIYKDFDRIVKARTSGGQVSALDEQRLRDYQIRRLRRLWLKDQILTAREPLLPPAKLTRIEKFQAAEDKFWGRFLKFRTLTPYLYLGSNFKEIPLLMLYKLQRSIRTYLFVFIPGTLIPLYFLMNMDSKIPNSSIQEKPRVYPGEKTFKARLEDVKIDPSTGQFQLPDAK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
Sequence:
MNAWEVNFDGLVGLTHHYAGLSFGNEASTRHRFQVSNPRLAAKQGLLKMKALADAGFPQAVIPPHERPFIPVLRQLGFSGSDEQVLEKVARQAPHWLSSVSSASPMWVANAATIAPSADTLDGKVHLTVANLNNKFHRSLEAPVTESLLKAIFNDEEKFSVHSALPQVALLGDEGAANHNRLGGHYGEPGMQLFVYGREEGNDTRPSRYPARQTREASEAVARLNQVNPQQVIFAQQNPDVIDQGVFHNDVIAVSNRQVLFCHQQAFARQSQLLANLRARVNGFMAIEVPATQVSVSDTVSTYLFNSQLLSRDDGSMMLVLPQECREHAGVWGYLNELLAADNPISELKVFDLRESMANGGGPACLRLRVVLTEEERRAVNPAVMMNDTLFNALNDWVDRYYRDRLTAADLADPQLLREGREALDVLSQLLNLGSVYPFQREGGGNG
The following text describes a protein:
Function:
Viral TLR3 homolog that probably prevents TLR3 dimerization and subsequent induction of IFN. Inhibits dsRNA-stimulated activation of NF-kB and IRF3.
Subcellular Localization:
Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein.
Domain:
Contains putative leucine-rich repeats (LRR) and a C-terminus cysteine-rich capping motif similar to domain structure of host TLR3.
Sequence:
MLRVFIFFVFLGSGLTGRIKPQVTCKYFISENNTWYKYNVTILNSSIILPAYNTIPSNAAGISCTCHDIDYLQKNNISIHYNTSILKTFQDIRIIRCGMKNISEIAGGFGKELKFLDLRYNDLQVIDYNILRKLIRSNTPTYLYYNNLMCGKRNCPLYYFLLKQEQTYLKRLPQFFLRRISFSNNNTYLYHFLSCGNKPGHEFLEYQTKYCRTKFPEINITVNQLIAKKNTERYKSCYPLVFISILCSCISFLFLFICLLRSICKKYSCTKQDKSSHNYIPLIPSYTFSLKKHRHPETAVVEDHTTSANSPIVYIPTTEEKKVSCSRRK
The following text describes a protein:
Function:
Component of the anaerobic respiratory chain that transforms nitrate to dinitrogen (denitrification).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=May be attached to the membrane by a signal-anchor.
Sequence:
MSEIMTKNMARNVFYGGSIFFILIFGALTVHSHIYARTKAVDESQLTPSVVEGKHIWERNACIDCHTLLGEGAYFAPELGNVMKRWGVQDDPDSAFETLKGWMESMPTGIEGRRQMPRFDLTDEEFRALSDFLLWTGTINTQNWPPNDAG
The following text describes a protein:
Function:
May be involved in a proteolytic pathway controlling the nuclear division phase of megagametogenesis.
Subcellular Localization:
Secreted. Note=Prediction of a peroxisomal location.
Sequence:
MSLEFGFILINIFTAIVSFSTLSHALLHPSSVSHNVSRSRYYMTTNELWFNQTLDHESPNDHRKFRQRYYEFMDYFRSPDGPMFMIICGEGPCSGIANDYINVLAKKFQAGVVSLEHRYYGKSSPFNSLATENLKYLSSKQALYDLASFRQYYQESLNKKLNISSGGSDNPWFFFGISYSGALSAWFRLKFPHLTCGSLASSAVVRAIYEFSEFDQQIGESAGQECKLALQETNKLLELGLKVKNKAVKSLFNATELDVDADFLYLTADAAVMAFQYGNPDKLCVPLVEAKKNGSDLVVTYSTYVREYCMRIWGLRVRTYNRKHLRNTVVTADSAYRLWWFQACTELGYFQVAPKYDSVRSHQINTTFHLDLCKSLFGKDVYPKVDATNLYYGGDRLAATKIIFTNGSEDPWRHASKQNSTHEMPSYIIKCRNCGHGSDIRGCPQSPMVIEGKSNNCSLPDYVNKVRQQMVEHIDLWLSECRQSIRSSI
The following text describes a protein:
Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MATYQLYRNTTVGQALQQTLNDFQAEDIISRALAERVMATFDKVINKTLNTKAKNKMNFKAEKLRAYRFCDNVWTFVMEKVEFREAITAPKERLKIVACDGSNKTLAPPAAP
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPSQDKEIDKIFLIGAGGFLGAVCRFLLCELVEGQLGILSVNVIGSFMLGMIMYDTEYLGFIGPKGKIAFGTGFMGAFTTFSTFAVQSFSLPFIPALGNISANIFLTLTGVFFGRSVIKALSSREI
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
Subcellular Localization:
Nucleus speckle.
Sequence:
MAPVEPVTVEEKVDESQTAPILKPTVGIIYPPPEVRNIVDKTALFVARNGPEFEARIRQNELNNTKFNFLNTNDPYHSYYKHKVKEVMEGKGQEPAASNIKSGLGFMPQKPISETQQKIIETIIPKEPPPEFEFIAEAPTISAFDLDVVRLTAQFVARNGRQFLTNLMNREQRNFQFDFLRPQHSLFNYFTKLVEQYTKVLLPPKDLVMKLKKETENPKYILQQVNYRVEWMKFQEREKKREEDEREKERIAYAQIDWHDFVVVETVDYQPHETGNLPPPTNPDEVGARIIAQERYEKHDGMWEDEEEVGVNEDGDEDRDYTGEVEEDHEGDEDGETAPASKQQQQQETVDMNGGTKEGSEVRGSHENDASLIRGADTSVQDMEEDSDDEEDKQQQQSNRQMPQHPPSPTMPPISQPPPLPPSLKGPPPPPNFNQPPPPPMATQTHYPAFSQDKIIIRKDYDPKAPKPADPSLQADKYLISPITGERILADKIQEHMRIGLLDPKWKEQTEKMIQERREQEEVYAPGSSIGSNLRQLAERRTDIFGSGAEETQIGKKIGEEEKKEKAKVIWDGHSTSMEKVTQKARENITIEDQIAVIHKNKGLVSDDDKEKIGPAMPKPQQQYQLQQQQIQQQIQQQQQIQQQIQQQQQSLMRPATTTAAPVMPPQQQQQQPPQQPPQQQQPPQQQPPQQPRPPMMLPTQSMIRPPIVPQMPGIRPALGLMAGMMLMGQAAQNAVAAGVMPMAHPPFLQPGNLLPALANQLMQPLQQQQQQLQQQKPKHPTGDDLEADEPAAKKSKTEDQLMSEQEFLAKNNGPVEFTVQMPLIDRSEWKLNGQSFTVTLPLTDTVSVIKAKIMEEVGMPAGKQKLQMDGMFMKDSNTLAYYNFSASTVVHLQLKERGGRKK
The following text describes a protein:
Function:
Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MDRRRWVPSTPVVTLLLLFMLFAPAPRLPSRNGESSEKSIKAEKRAFSEIKNATFLNIPERVEHSLTFPTEIWETRDGLFEEPVGKGDSHLNHTSVMTGNWNILPYPSFGKVSPNVTWHTTLRNIVMSQSGRFSANLYEYVDGNSDGISFVLNLENNNDTSVYHMTFHGDRVKPINVFLGSTDVTPNFGGVDVIPWLLKDSPYKDAPPLDGTEYFPLLQNRSLERIETRLQDAQTVGWSPLVFEEEEVTCSAFVFLHNKNTGLDKETLKAIENEFYHPQGVSTQKMPEVFVSGLVYSPDCNVAFTFSNTKGPRNFVLENHLVRFSSLYIFIVLSQIFVLLRQMRINSPSHVQRLSFLTIAMQAGLDAYIAIFFLSTNAVIEKGYLPFVSVAFLSLVPSVMFTMRYLALILRVQNSNMPPPAPRPVTNNSSNNNTNQSNASNENSPNAPSAANDNTETTTVNPPQEDDQPMTQHERDQRDWSAVCLRFYFIILVVCIASLYSAFWPVIYRFYFISALIFTSYSFWIPQIIQNVKQGTSRSFTWTYILGASVLRLYLPLAIFIDSELILGFPPKYFFALGLVLWMLFQVLVLLVQDTLGPRFFLPKKFFLSSPVYDYHPVIQQDDLEAFMRDANVCPICMQPIELVSTGSTLNPASMMVRRNYMLTPCHHLYHRQCLLQWMETRSICPVCRCHLPAV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MSNVTSALAACAPSSILSITAANACTAAVPTLSAAARLITKPGTALGSGTCQADARDVAALLAHRAHSTARAAVGGGAEEAPREGSAVAGGSSSDQRLVANVSGARQQASCTANAAPVETQGLTAAGACGSLPAPPPIFNETQLRSVATATSAIAASGRGSSLACRAFGGPNTATSTGGPAVGGSSFSGRPGGLLWPDRRNRVGHTPQPLAVSDRRGLAAAGGRASLLHALGLLPAAGGVGAPTALATAMAAAAAPAALPWPAACRAAFASSAHAAVARRRGEELEGGGEGRAAGTGAAGGAVSSATDTWLPEPLAAAAAGGGGGGSASGGGGSSGGPQSRALQAPAHAYVGRDGPQGLMEELAAAAAASSSPYIQQALRQLAAGGGGSGGTRAPAGAGAAAPAALKAAAPSNGGRQDSDSGAASDALLREVLAVAGSVQSRGFRAALQAVVGKEGMPKLKPKPKRVTSTGRKATEPAKAAGAAAAPATVPAAPAEAAVAPAPAPASGPASAAGALLPEAASGAEGSGASPAPKRRKRQTASTASTASAASDTAAAASHEVALAAAVGQDSPGGPGSAAGAVAGKRPRGRPKKDAPPSAARVAAAATAAEAAAERAAAAAEEAAAQQAAAERELSSSSSGNGPRPSFGSSVLSPVPPPESDPRYVSMADADALQPGNSLYVGRLVEWHAAHVDAVLAAPARTPGLPPPSLQDFQLQLNLEARCRNLAVEQYRREQEALVARGAVEGALPARRLTEAWLPRLTAALTARFNQFAALQDPAKQQRRRGSAATSTINLRKGSGSGSGGKGRSYVPLEQALKMMDSVGAGAANKSSDGTDTAAAAAGASTSTSTAAGAVSSAGGGGGSDGGAGDGGGGGGATASAWAAVAALPPVRLRELAEWVPMVKSVPPELLARAAVSGMLNSLVLRDSGVAGEGEDMPRGVALAVHVADALGRRVLDMVTYMEVCAVVHEKRRALARAKQELGAAMGKAAAAAAAGAEGGLEAAAVAGGQGGGEAGAAAAAAEDSLMMDPVVSEAAAKVRATRAELEALRAAAAALQPAAADGQLLNDGTTAEARRRAAPLKARGSGLSLEQRAAALGQRTQDQLSAVMDRIGRRVRQDELDGALFAALAGARTAAQRVDVTRAWQAALSQAADRLQQQLGAGAAEAEIAEAAKGVAAGGAKQRVRKGALEAADGDSGGGGGGGLTAAQAAELKSRHATLQVALTKAGVQLKAAEEMLAAEEAAAAAAAEEKVKASPRKAQGRPKKTAAAGSGAAATSPSAAAPVQALDLDQVMAQERDATTATASATAVDTDAAAAGDGAGLGDALQHLHRSVLRRVVAGTDRAQRPGEWDQSTRVKVGACLLDLMLRLLEVEVEAEADEAAEAEAADEEAVGGGGDSGRAGGRQRVMEPALRHSTGAAATFHHGGFQTPGLVMLHPQVLRQLEGDVALQRLLQPRFMPMVVEPRPWCGTRAGGFLSQTVPVMKTQYSPAVMERLASAHAAGRMTPLYQALTVLGNVPWRIHGRLLDVMETVQRQGGGRLGLPQNQPQELPTRFTSALNHVWRPLLGADTPAQCGTPYLRLQREGRRGGQLLVGAGRMSESEEEAYQHQCDAVRLLNRNESGLRCALKYRLDVARQYTGRYDLGAGVYQLYGTDVPTAADGAVAAAAAGGGEGGGGGGGGLLAGSAAGSGRPILFYQPHHVDFRGRAYPLHPHLHHLGDDATRGLLQFGRGRPLGERGFDWLLMQVANLWGQGVDKRPLAERLEWARQQLPAVRAAAAHPLEGGGTWWQRAEKPWQMLATCFEVADALDSSGGVNPTAFISHQPVNQDGTCNGLQHYAALGRDLRGGTAVNLVPADRPQDVYQAVADAVAERVELARAQGRSEAAKIHGHVDRKLVKQSVMTYVYGVTFVGARDQIESRLEERGWGNPKERRKVATYVAGIVFESMSDVFGPAVRVRSWLEDCAKYAVSAGAPVVWTSPLGFPVEQPYRKVPTLSVHTSLQTFSIRDNSRDAVSPLDVRKQCSGFPPNYVHCLDGAHMMMTARAVREAGACFAAVHDSYWTHAASVDLMNKAIRDTFVQLHERPLLHELRRELLRNPEYSGATAALPRVPAPGQLDLSVVRQSTYFFS
The following text describes a protein:
Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.
Subcellular Localization:
Cell membrane. Cytoplasm. Nucleus.
Sequence:
MAYTPGGGAPARGAAPVGSQYCVCKVELSVSGQNLLDRDITSKSDPFCVLFTENNGRWIEYDRTETAVNNLNPAFSKKFVLDYHFEEVQKLQFALFDQDKSSAQLDEHDFLGQFSCSLGTIVSSKKITRPLLLMNDKPAGKGLITIAAQELSDNRVVTLSLAGRKLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPVQVMCYDYDNDGGHDFIGEFQTSVSQMCAARDGVPLEFECINPKKQKKKKNYKNSGIIILRSCKISRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQQTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRTLRSYTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTHSEPA
The following text describes a protein:
Function:
Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVHAVKLSELSKRKRDVEEDSDVDISTTDSESDQDADGDEEIINIDFDFFNGNPGVDFHALKNLLRQLFGQQEANRMQLSTLADIILQSPTTTIKTDGQESDPYCFLSFVDYKEHRTSDYAKYLVNLDPRLETFFATIDNSDKTCALILCERLINMPVEVVPPLYNITLNDVSSNSSDGKHFDFYLVVSRKYEVSFDMDSDSEDESAKPRKRVKGSELDYFHEEDRHMEKYAKICFQGPTRKGVVPLYMVLDHEGLVRSIGDLEQAIASWK
The following text describes a protein:
Function:
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E (By similarity).
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein. Note=Following cleavage by DegS the large fragment of the protein is still in the inner membrane and retains its anti-sigma-E activity.
Domain:
The N-terminal cytosolic domain interacts with sigma-E. After degradation by RseP binds to SspB, targeting RseA for degradation by the ClpX-ClpP protease (By similarity); The C-terminal periplasmic domain interacts with RseB and is also the target for DegS.
Sequence:
MQKEQLSAYMDGEQVETDLIDALLRDEELQASWHSFHTVRSVMRKESAVFLGADFTAKMADLIELEDVKKVDVIAVSQPEPEDAHNSVFMQKLKAFFAPMTQVAVAAGVCLVAVLGVQSFNNKNDASNLPETPVLQTLPFNNAVQEVSYNAPSKDTLTSDQLEKKSRRIGAMLQNYELQRRMHSDALDVSSSQVR
The following text describes a protein:
Function:
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Subcellular Localization:
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MRVGGSELTFPLLKGLATMKLHRKPVLSYLRGTGARAPDREGILLKKGTRNPSYQRRWFILRGNLLYYLENRRDRTPLGLILLDNCQVEPRDSTTEPYAFAILASAREGGRCYKLAAESKAELDGWLRALVRAGWSQLWELLQPLQEQYQRVCQEAGVEPQAPPQEDRFLDLPSSPAPSSFQELHQRFGEEIQALARSRATKKQTDLMEFG
The following text describes a protein:
Function:
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MYTVADLKKGLKLTLDGAPYLVIAFEFSKPGKGQALYRTKMRNMITGVILDRTYRSGETFEPARLEERRMQYLYKEDTHYTFMDNQTFEQVQMDEDAVGDAKNFLIDNLEVDILLFGEKAIGVTLPNFVNLRVVQTDPWVKGDTSGSDSKPATVETGYILRVPPFIEEGEMIVIDTRSGEYSTRVKG
The following text describes a protein:
Function:
Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.
Sequence:
MLTLAADIDVLARFGRALADPIRCRILLALRQAPAYPADLADSLGISRTRLSNHLACLRDCGLVVTVPDGRRTRYELADERLGHALDDLRAAVVAVEADRTCADADEKGCC
The following text describes a protein:
Function:
Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. Also seems to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton.
Miscellaneous:
MISCELLANEOUS: Present with 2540 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Note=May also be mitochondrial.
Sequence:
MSISETPHNKSQGLQKAAGRPKIVVPEGSPSRNSDSGSFTIEGDTSLNDDLLSISGSVTPRARRSSRLSLDSITPRRSFDSRTLSVANSRSFGFENETHSGSMDFSPLGNNSIYEIVMNTRRKNWLNYPTVADIPQVSLSKNDLDDHWKTHVIEYVKNIKSDYQIFQSTNNIRNMNQMEQLKELREGENMHEESFEANLRQGDAELINSIPDFYFSDKFQLDNPRTFHKVLDAIDLFLTKLDMKRQAERDEAFSELRDRLNDFLDIVETLLVTEISKSSHKFFHALSEVDNIQKRALDTMSELKELAQNIKTIDAENIRKKISHLEMIFKRKNVEKLEQGLLQAKLVLNKTDECKSMYEENKLDNCLELIKSIDYLIKGDDSINEDVQSWTRCWPYKLSNLRTIPALSATREFLTNMKIEIGGKFSLQLSILLIDDLRSFCKSIKPKETLHRIQTGSNDKKQTIFTDNFSSKITELIVRLNRCEELTSAFDLYREKSITELKSIIKIYLPTENAHADNNHDEKHLNNGSTSGSKLSRLIKEQTPAEFQSMLVNIFTHALEALRRLYGHQKLLLDISLNELASVKSPNENQHNMITQLDIRTGINEIIRIIQLRTGKIIAVRRELNLSLRYDYFLKFYAICVIFIQECEVLSGEFLTKYLSNVLASQIKHYANAQSSKNYRNIKKKIDAEEWIPYIVDSSIQSDVNDIVSSIDIDPLSWTTILDMVGGSHDCENGRSEDKEKDEGNETYQGHRKSVVVGDKTFVASSSLLATIEVIKELMVLSINLPSIYLSNFEKLCYDALQYYNSSAMASVTQPGNSLLKTGRNLSIMGESLDCLAEFVIIVQRFYQRLSNSNRDFEPFDASHYTTLLGQFQASSNKIYMANAPPPPV
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MADDEPVDPKKYLEESCKPKCVKPLLEYQACVKRIQGDETGQKHCTGQYFDYWSCVDKCVAPKLFHKVK
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MNIVALLVKVAGLFATITVGANAFSYTRFRRRNLGKIRSPIDESKEVLADFNSHEHKEGKFFFGLATAPAHSEDELDDAWLQFAKETPSSPSDAVPGSEAANRKKIKLAVGAITKGLAKNKHIKEVKASASADVKPPTNNVAAWHNAPHAEDRLMFWSDPDKEVKLAKETGVTVFRMGIDWSRIMPKEPTEGIKEAVDYEALEHYKWILNRVRSNGMKVMLTLFHHSLPPWAADYGGWKIEKTVDYFMDFTRLVVDSMFELVDSWVTFNEPHVFTLLTYICLKKPLVGIAHHVSFIRPYGLFDTGAVTISNSLTVYPYIDSISKKLDFIGINYYGQESVCGVGIKLVETDEYSESGRGIYPDGLYRVLLMLHERYKHLKIPFIVTENGVSDETDVIRRPYLIEHLLALYAAMLKGVPVLGYIFWTVSDNWEWADGYGPKFGLVAVDRSNNLARTLRPSYHLFSKIVKSGKITRKDRSLAWNELQKAAKSGKLRPFYRAVDNHGLMYADGLDKPQWRPYVDRDWRFGHYRVDGLQDPLSRVARVLLIWPLIMNKRIRKVKVKHTDDTGAAYASPFN