lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Sequence:
MELNKNYLTQEGFKQLEKELENLIQVKRPEIIRLLQEARDQGDLSENADYDAAKAQQGEIETRIAEIQDILANAKLISDHQAKTKVTKVSLGSTVEIYDYSSKSNEKYTIVGTLEANPEEHKISNESPLALAIYGRLIGDECDVVGIEVPYRVKILKISNR
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
TGRGAGPAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK
The following text describes a protein:
Function:
Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular Localization:
Secreted.
Sequence:
MRSVASYIAASLLMAAGCALCQGPPPPWPGGHQFIGQPPQAPVDPLSSSHWRPVSASSTRVGAIGAGAGIQPRPFGEPAGFAGSEASTGRGPLPGAYPFMGRAGRTPDASPGGIPSAQGGMMGGSVGGNAGSAMSDQLRLESDFPGKPTAAIMYTYVPSTFKKGNPVIVALHHCAGTGPGYFHEYADWPKMADKKGFLMIFPSSPGGTGNCWDVSSKASLEHNGGGDSQTIAEMLKFAIKKYSCSDKAYLVGHSSGAMLTQVMATTYPDLFVAAAAYSGVPSGCFSTQKAKGADWNSTCAGGTLNESLQYWVQQARNMYPGYKGQYPRMMLVHGDQDAVINFNNHREAVKQWCGLHDLNPETPDKKYPLPSQPNYEISVYGSSAVMAISAGHVTHDNPAKGMRLRGLSVLIRLKKPS
The following text describes a protein:
Function:
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Subcellular Localization:
Nucleus.
Sequence:
MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAATAKGAAGATGAKKGEARCSSEDDDSKESTCSHTPDSTASLPPPPPAPSLASPLLSPSPLPAALGSGPGPQPLKGALWAGVAGGGGGGPGTGAAELLKAWQPAEPGPGPFSGVLSSFHRKPGPALKTNLF
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MTPSLKKSPKIENACFKLITEDKEEVLISELAMKHSKFLTDFVSNFGFSPSVNGEKNPIQIQKVTGPTLKLIVKWCEHHKNDPKIREMDYCKVTAEWDQQFLQMDNEVMFDLVRASNFLDVRILFAISTKTIATWIKGKNSEQLRAIFGGTPSEKSEEKRKNSVGNNEKRRKIE
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Miscellaneous:
MISCELLANEOUS: Present with 4300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLSATYRDLNTASNLETSKEKQAAQIVIAQISLLFTTLNNDNFESVEREIRHILDRSSVDIYIKVWERLLTLSSRDILQAGKFLLQENLLHRLLLEFAKDLPKKSTDLIELLKERTFNNQEFQKQTGITLSLFIDLFDKSANKDIIESLDRSSQINDFKTIKMNHTNYLRNFFLQTTPETLESNLRDLLHSLEGESLNDLLALLLSEILSPGSQNLQNDPTRSWLTPPMVLDATNRGNVIARSISSLQANQINWNRVFNLMSTKYFLSAPLMPTTASLSCLFAALHDGPVIDEFFSCDWKVIFKLDLAIQLHKWSVQNGCFDLLNAEGTRKVSETIPNTKQSLLYLLSIASLNLELFLQREELSDGPMLAYFQECFFEDFNYAPEYLILALVKEMKRFVLLIENRTVIDEILITLLIQVHNKSPSSFKDVISTITDDSKIVDAAKIIINSDDAPIANFLKSLLDTGRLDTVINKLPFNEAFKILPCARQIGWEGFDTFLKTKVSPSNVDVVLESLEVQTKMTDTNTPFRSLKTFDLFAFHSLIEVLNKCPLDVLQLQRFESLEFSLLIAFPRLINFGFGHDEAILANGDIAGINNDIEKEMQNYLQKMYSGELAIKDVIELLRRLRDSDLPRDQEVFTCITHAVIAESTFFQDYPLDALATTSVLFGSMILFQLLRGFVLDVAFRIIMRFAKEPPESKMFKFAVQAIYAFRIRLAEYPQYCKDLLRDVPALKSQAQVYQSIVEAATLANAPKERSRPVQEMIPLKFFAVDEVSCQINQEGAPKDVVEKVLFVLNNVTLANLNNKVDELKKSLTPNYFSWFSTYLVTQRAKTEPNYHDLYSKVIVAMGSGLLHQFMVNVTLRQLFVLLSTKDEQAIDKKHLKNLASWLGCITLALNKPIKHKNIAFREMLIEAYKENRLEIVVPFVTKILQRASESKIFKPPNPWTVGILKLLIELNEKANWKLSLTFEVEVLLKSFNLTTKSLKPSNFINTPEVIETLSGALGSITLEQQQTEQQRQIILMQQHQQQMLIYQQRQQQQQQRQQQQQHHISANTIADQQAAFGGEGSISHDNPFNNLLGSTIFVTHPDLKRVFQMALAKSVREILLEVVEKSSGIAVVTTTKIILKDFATEVDESKLKTAAIIMVRHLAQSLARATSIEPLKEGIRSTMQSLAPNLMSLSSSPAEELDTAINENIGIALVLIEKASMDKSTQDLADQLMQAIAIRRYHKERRADQPFITQNTNPYSLSLPEPLGLKNTGVTPQQFRVYEEFGKNIPNLDVIPFAGLPAHAPPMTQNVGLTQPQQQQAQMPTQILTSEQIRAQQQQQQLQKSRLNQPSQSAQPPGVNVPNPQGGIAAVQSDLEQNQRVLVHLMDILVSQIKENATKNNLAELGDQNQIKTIIFQILTFIAKSAQKDQLALKVSQAVVNSLFATSESPLCREVLSLLLEKLCSLSLVARKDVVWWLVYALDSRKFNVPVIRSLLEVNLIDATELDNVLVTAMKNKMENSTEFAMKLIQNTVLSDDPILMRMDFIKTLEHLASSEDENVKKFIKEFEDTKIMPVRKGTKTTRTEKLYLVFTEWVKLLQRVENNDVITTVFIKQLVEKGVISDTDNLLTFVKSSLELSVSSFKESDPTDEVFIAIDALGSLIIKLLILQGFKDDTRRDYINAIFSVIVLVFAKDHSQEGTTFNERPYFRLFSNILYEWATIRTHNFVRISDSSTRQELIEFDSVFYNTFSGYLHALQPFAFPGFSFAWVTLLSHRMLLPIMLRLPNKIGWEKLMLLIIDLFKFLDQYTSKHAVSDAVSVVYKGTLRVILGISNDMPSFLIENHYELMNNLPPTYFQLKNVILSAIPKNMTVPNPYDVDLNMEDIPACKELPEVFFDPVIDLHSLKKPVDNYLRIPSNSLLRTILSAIYKDTYDIKKGVGYDFLSVDSKLIRAIVLHVGIEAGIEYKRTSSNAVFNTKSSYYTLLFNLIQNGSIEMKYQIILSIVEQLRYPNIHTYWFSFVLMNMFKSDEWNDQKLEVQEIILRNFLKRIIVNKPHTWGVSVFFTQLINNNDINLLDLPFVQSVPEIKLILQQLVKYSKKYTTSEQDDQSATINRRQTPLQSNA
The following text describes a protein:
Function:
ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSITTTRRRNQDSVCCKATRASIKVEAVSGQTVFEKQKLLHNFDELPEWQKDNDKILTGYVRETLSWKKCLYSLFYWNNETVNIYTHLVPAIVYFVFAITLTNYFLIPVFPSTSWSDYTVINIFLMGAFSCLMCSSCFHCMKQHSEKQSNFWSKLDYLGIISLISCSMIPIIYFGYFDHISYFSLFTIVTLVLATFCTVCVLHDKFNTSTFRPFRAMFFILFGFSGLLPLTTGFFKFGIQGVLNRIKVSFVFWEALFYISGAVIYGFRIPETLAPGKFDFFGSSHQIFHIMVVLGSVCHLKAIIDSYKLMHSHIHP
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MEENSNFGERLPPTVTGLSPTEGVPGTQITIRGENLGCDQSDVIMLFICGIDSLWSMKWKSPSKIIARVGAASRGPGEVRIVTKSGGKGTSNVKFRVFITQIGPLEESAVWVDETRTVPGREAIRSVPQIQDERDALGLVPSQKRIDQVMLSRDFPDCSGNLRMENFSPQWYLLENHADATIEDLRTAIKNMELAKQNDAKRSEEMHKANLYSLINCVDTLANLHQALEKGQNADHFAALGNISKLIKDSKLKAESVFADVLKRKDDADATRNALGVIVRFKFIFFLSSKIEESMKKGEYITILNDYTRAKSLYADTDVPLFRELMTEIDAKMEVFKEEMKRKLIDTPLSYEEQSKLIKYLKILDPESDPTWDCITSYYVWLEKNLWELQEKFLEKAKIEDVESQQRFHQNPASSHFTKSNELQNFVTTLVELLLSKLPSFWKLANTYHASSGSPNAIQRLEDINEMLTKLINVSSWLVLNALITKALPDSVLNQYSNQFAKWPPVSADISRSNLQQSLKTTRSLIASLLENQFNLSHIAPLVELCMTVRLKLVSDFVECGIERIALLAHRINWKQDILDRAQQTKTILPDYYENEICECLSRTRDALSTTGYPGEACLFSRDRFRDTIIDLFVHLITSIKICFDRLFTRQRPQALVLDEKPKKGGQEITTKKLLIAVGDIEFIIAKTLNNVGKKMQECGVKHVDQIQEKSRAKLSAFRTKMINDCIAMMGSAFQPLIASATYEYLPDDDDISDYAKEMILCSVLQQAELELYAPQLAVECLQHTVSTALDALLTHFSRLNQDTSPLIVTQIVIDLTGLEEALSSYATLAIRVQINSYRAGLVGRFDNLRLQQCLKNMRTTMRMALQSLEQHADTIDDDANNTSAI
The following text describes a protein:
Function:
A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Mediates chloroplast nucleoid segregation during chloroplast division.
Miscellaneous:
MISCELLANEOUS: RNAi mutant displays chloroplasts with no chlorophyll and aberrant nucleoid morphology.
Subcellular Localization:
Plastid, chloroplast stroma, chloroplast nucleoid.
Sequence:
MATTVYGQASLPQMHSLFSKVRPFLSHSPSFTAPFTRRRSFPFSALPTTKAIDAALMKEKWLDSLSLTSQDEDTTPENAESSCIIGIDPDLSGALALLKFDHLGSSSFAQVYDTPHIPVLVGKRVRKRLDAKSIVQLIQSLDVPSGSRVYIEQSNPFPKDGKQGWYSGGFGYGLWIGTLVASGFCVIPVSASLWKRHFQLASGSCTKDDSRRVAAELFPSLSSQLKRKKDHGRAEALLIAAYGEALKTEKLLIQPKELLSQVNYLENQLVEVK
The following text describes a protein:
Function:
Monoterpene synthase involved in the biosynthesis of monoterpene natural products of the 'cineole cassette', volatile compounds present in floral scent. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into 1,8-cineole and, as minor products, limonene, sabinene, (E)-beta-ocimene, beta-myrcene, alpha-pinene and alpha-terpineol.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MNHHLIITPIFHLQIMLPVATLKRPPPPAATCSIYSFSRGTPSLVSKARLSTAAVGGMKNEPSPNHYSDISSSDLNLTRRSGNYGPTMWDFEYIQSIHNDYTEKKYMNRLNKLKEEMKKMIMAEGSQELEKLELIDNLQRLGVSYHFKHEIMQILSSIKQHSTPADSLYATALKFRLFREYGFHISQEIFGGLSETHTEDTKGMLYLYEASFLATEGESELEKARNWTEKHLREYLENKNDDQNVAELVHHALELPLHWRMLRIEARWFINFYKKKQDMIPLLLELAILDFNIVQAAHIEDLKYVARWWKETCLAENLPFARDRLVENFFWTIGVNFLPQYGYFRRIETKVNALVTTIDDVYDVFGTMDELQCFTHAFQRWNIDELDNLPDNMKMCYFALDNFINEVAGDAFEEHRVPILSYLRNAWTDLCKAYLREAKWYFSKYIPTMEEYMDNAWISISAPVILVHAYFLVANPVNKEVLHYLENYHDIIRWSALILRLANDLGTSSEELKRGDVPKSIQCYMNEKKVSEEEARQHIRLLISETWKKLNEAHNVAAHPFPKMFVKCAMNLARMAQCMYQHGDGHGHGDLNSETTNHIMALLFESIPPA
The following text describes a protein:
Function:
Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.
Subcellular Localization:
Virion. Host nucleus.
Sequence:
MLADGFETDIAIPSGISRPDAAALQRCEGRVVFLPTIRRQLTLADVAHESFVSGGVSPDTLGLLLAYRRRFPAVITRVLPTRIVACPLDVGLTHAGTVNLRNTSPVDLCNGDPISLVPPVFEGQATDVRLDSLDLTLRFPVPLPSPLAREIVARLVARGIRDLNPSPRNPGGLPDLNVLYYNGSRLSLLADVQQLGPVNAELRSLVLNMVYSITEGTTIILTLIPRLFALSAQDGYVNALLQMQSVTREAAQLIHPEAPALMQDGERRLPLYEALVAWLTHAGQLGDTLALAPVVRVCTFDGAAVVRSGDMAPVIRYP
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGENYCSVCEGIISTENDLAVCYKCKEEIFHKACGKKVFDSLRCLNCGPIEKRSLSHQIGEISKGKAKLETRTSRFTGINVTKEFIESGEYGISKGDDDDDGDYVGGDDSSSDDEYFGNPTVLNNYPTTMNNVDLNFPTFFLLNEDMKKRKQKIKEDGNNEEIKKIEQEEKMIIQEYQNEEILKFFGDRSCFKQTQLAYEAMVQCLKDLKESIERMFKVVSVKTLGDISSFISMSYPKKSLLDIRDIALELIGQSIDDSIHHIPTSILYTSSSSPEVAQLFQSVPSNVMMRIKSHQPFSSDISSHLCEPPTITLNPDCCNTFKSTVSTICHSLTKDYDVTKFPSPHFEDLSRWYSNYFSIPLIQEVIELFKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKDKLEEIMLVRTPVILVIEDFETWNSEVLSDLIHLLSAYRHRIPFVLSFSISTSADAIHKVLPYQVVSLLNLKSLHLRSQNEMFEQLVKHLFLKSQPYIISKKAYLYLYYNFKNSYMSLSTTISVLRHFIIDHFLENGLSYLTLDLSNFQIDLKDDDDDMDGCSTIKLEPENDSTDSTVNDEVGTGDNIDNDNVSTHGEEDTPDSLVKSDIECQTLSYSSDDERNDYDTSTDSDNCSNFHKKKPNSNNRIKSDLECNDNDKDNDDNDNDINENNNNINNNNNNNSNNDDNDKDSFGPKRIPNQRFVTLIQKLPSLNTDEIENSKISTNRKLNKLQSNLIIFKESRPIMLELYYTILSKFQKSKTLKYSELLKKISLNDRKSYETLRKTILTNPESKQSIETLLDLLKTSRHHFERIIKATNSLKLFQTPKSKKYQDLVKIENLILKCRTLSNNFKNLLLPPDEQSKSIKNEIKQQQQQQQQQQQQQQQQQHQQQQKIENEQKNWSIKKKREHQLRNIQKPTDSYFKIYSREFLDDIVSVIIEDYLYPPLVSVPLSEIFDFTQTVFITQSRFNFHTAEGINDNLIHSVRKLKCECCIDSLCGTMDDFSISFILLLRSGRYINYFDWLTSFCSIINGDNNPTPNLKARFIKSVDTFVSLELIKKTRKRKDHFEKIAFLTTS
The following text describes a protein:
Function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Sequence:
MRYPGRMTDAPPDPRARYLALRDEVALHNRAYYEQDAPTIPDDEYDRLARELRELEAAHPEFADDHSPVQTVGGAPSSAFEPVTHPTQMTSLDNVFDDDELRDWQEKLARSLGLPLDTDDFTFTGELKIDGLSVNLYYLDGELQWAATRGNGRVGEIVTAQVLTIPDIPQKLEGLKGELEVRGEVYLSRADFAAFNAQAEELGTPLLKNPRNGAAGALRQKDPEVTRTRHLKAILYAVGKRDGVPARTQWEVLEWLSAQGFPTSRSSEHLRGIAAAADYHARMIRAHADFEFDADGTVLKLDSLSQQEEAGFTSRAPRWAIAYKFPVEEVETVLESITVNVGRTGKLAPLAHLSPRLIEGSTVSKATLHNEDYIRDMDLRVGDTVLVRKSGGVIPQIMRVLPDKRPADAAPFEFPTHCPVCGHEAVRAEGDANTYCPNPACPAQSFERIRYFVSRGAMDVRGIGEKLVTQLLHEGLIHDAAGLYTLSAEQLAGLERGGEKKAGNILGQLEASKTKPLWRLINALGMSHVGQRNAQALARAFGTLEGLLAATPEQIEAVPGLGGIIAQSVTASLADPAMRDLIARLQASGVAPQAEEVTRTDQLSGLNFVLTGALSRPREVIKAELEAAGGRVTGSVTKKTSYLVAGEDAGSKLARAGELGVPVLDEAGLAALLAERGLGERGVAEDGMSGAETEAAPAES
The following text describes a protein:
Function:
May be involved in thymocyte signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MQTCPLAFPGPISRALGTLLFLAASLSAQNEGWDSPICTEGVVSVSRGENTVMSCNISNAFSHVNIKLRAHGQESAIFNEVAPGYFSRDGWQLQVQGGVAQLVIKGARDSHAGLYMWHLVGHQRNNRQVTLEVSGAEPQSAPDTGFWPVPVVVTAVFILLVALVMFAWYRCHCSQQRREKKFFLLEPQMKVTALRVGAQQGLSRASAELWTPDSEPTPRPLALVFKPSPLGALELLSPQPLFPDAADP
The following text describes a protein:
Function:
Glucosyltransferase involved in the last step of benzoxazinoid glucoside biosynthesis. Catalyzes the glucosylation of hydroxamic acids utilizing UDP-glucose as glucose doner, reducing the toxicity of these natural insecticides for storage. Can use DIMBOA and DIBOA as substrates, HMBOA (2-hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) and HBOA (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one) with a lower efficiency, but not indole acetic acid or quercitin.
Sequence:
MHTDDVFLASLLPDREDRGGQTQKRSLTTAAAMAASCGGRVVVFPFPFQGHFNPVMRLARALHARGVGITVFHTAGARAPDPADYPADYRFVPVPVEVAPELMASEDIAAIVTALNAACEAPFRDRLSALLSAADGEAGEAGGRVRCVLTDVSWDAVLSAARGLGVPALGVMTASAATFRVYMAYRTLVDKGYLPVREERKDDAVAELPPYRVKDLLRHETCDLEEFADLLGRVVAAARLSSGLIFHTFPFIEAGTLGEIRDDMSVPVYAVAPLNKLVPAATASLHGEVQADRGCLRWLDAQRARSVLYVSFGSMAAMDPHEFVELAWGLADAGRPFVWVVRPNLIRGFESGALPDGVEDRVRGRGVVVSWAPQEEVLAHPAVGGFFTHCGWNSTVEAVSEGVPMICHPRHGDQYGNARYVCHVWKVGTEVAGDQLERGEIKAAIDRLMGGSEEGEGIRKRMNELKIAADKGIDESAGSDLTNLVHLINSY
The following text describes a protein:
Function:
Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
Subcellular Localization:
Cytoplasmic vesicle. Rough endoplasmic reticulum. Synapse. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
Sequence:
MNLPSTKVCWAAVTLLLLLLLLPPALLSPGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRHCPAAAATSVAPGGQSGI
The following text describes a protein:
Function:
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
Miscellaneous:
MISCELLANEOUS: Present in outer membrane vesicle formulations which are used as vaccines in human.
Subcellular Localization:
Cell outer membrane.
Sequence:
MARLFSLKPLVLALGLCFGTHCAAADAVAAEETDNPTAGESVRSVSEPIQPTSLSLGSTCLFCSNESGSPERTEAAVQGSGEASIPEDYTRIVADRMEGQSQVQVRAEGNVVVERNRTTLNTDWADYDQSGDTVTAGDRFALQQDGTLIRGETLTYNLEQQTGEAHNVRMEIEQGGRRLQSVSRTAEMLGEGHYKLTETQFNTCSAGDAGWYVKAASVEADREKGIGVAKHAAFVFGGVPIFYTPWADFPLDGNRKSGLLVPSLSAGSDGVSLSVPYYFNLAPNLDATFAPSVIGERGAVFDGQVRYLRPDYAGQSDLTWLPHDKKSGRNNRYQAKWQHRHDISDTLQAGVDFNQVSDSGYYRDFYGNKEIAGNVNLNRRVWLDYGGRAAGGSLNAGLSVLKYQTLANQSGYKDKPYALMPRLSVEWRKNTGRAQIGVSAQFTRFSHDSRQDGSRLVVYPDIKWDFSNSWGYVRPKLGLHATYYSLNRFGSQEARRVSRTLPIVNIDSGATFERNTRMFGGEVLQTLEPRLFYNYIPAKSQNDLPNFDSSESSFGYGQLFRENLYYGNDRINTANSLSAAVQSRILDGATGEERFRAGIGQKFYFKDDAVMLDGSVGKKPRNRSDWVAFASGSIGSRFILDSSIHYNQNDKRAENYAVGASYRPAQGKVLNARYKYGRNEKIYLKSDGSYFYDKLSQLDLSAQWPLTRNLSAVVRYNYGFEAKKPIEVLAGAEYKSSCGCWGAGVYAQRYVTGENTYKNAVFFSLQLKDLSSVGRNPADRMDVAVPGYITAHSLSAGRNKRP
The following text describes a protein:
Function:
Transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MGFREDPQGGQLNTMLDAMEVPSHSRQLLLQLNSQRTKGFLCDVIIVVQNALFRAHKNVLAASSVYLKSLVVHDNLINLDHEMVSPTTFRIILDYIYTGRLGDAELSSEQLFGSVLAAASYLQITDLVSLCKKKLKRNGKYCHVRTTGYPPYGSLGRGQKASTPVIQSCFSSSSRPVDLQPVEPVNTHCAELYAQGNQLHQHGLCPPERRCSPLCGLDLSKKSPPRSSAQLLSDGLAAGGDSREPAVPGRQDSPPVSASLLANHSDSYKEPPHPYQRLNSNEAPAPHSESYRNTDHPSRTESQQELMFRWMKHEPLASYVDESDREKDLDREDKGESSPLSQQPRYPSIESNEPDDDKSTSEDTGSSEDPSPSANLDRYHCNHLGYEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHNEEELYHKESLEPPVQFLDKSNQGLGDIIRPYRCSSCDKSYKDPATLRQHEKTHWLTRPYPCSICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHTTGPDGKPKLDFSESVYAMAKFTADHLGLKQEKAAEILSQTSHFLNDPKTIESLYPLAKFTAEHLGLTHEKAAEVLGPIPHLGSDSRIIERFSSP
The following text describes a protein:
Function:
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGVAESKQKQNMNYFLLVTFILSVLQATDCQRITSLTACLMRPGPKLRIDCRYLNTTNNPMRYEFKVNRGGEPQIILSTINVNFFSDKYHNRASPSITRGLVQLHLERFNASDAGLYTCNLFIPNDLTINQTASIGVQKDKLETCGGVSLFNHGSSWPFAFLLSLHLLLAGGFVSF
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.
Subcellular Localization:
Cell membrane, sarcolemma. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MAEEQRELEERIIIKDQHTKEIDLVNRDPKRINEDVVKVDFEDVIAEPVGTYSFDGVWKGSYTTFTVSKYWCYRLLSAVLGIPLAVVWGFLFALISFCHIWAVVPCIKSYLIEIQCVSRIYSLCIHTFCDPLFEALSKICSNVRVMLRKET
The following text describes a protein:
Function:
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation; This promotes the activity of RNA polymerase II.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Nucleus.
Sequence:
MEEPADSGGGAAAEGPVVQVTEIRCPAGARPLRLLEWKVKPGALVNVDSVIAVCAPIPAESESRAPEKKLKSDRAGVVQELCCQLGQVIAPGTVIAKVEECCHPIVMKGLCAECGQDLTQMQSKNGKQQAPISTATVSMVHSVPELMVSSEQAEQIGREDQQRLHRNRKLVLMVDLDQTLIHTTEQHCQRMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLFELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECIDPFSKTGNLKNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYIYFQGTGDINAPPGSREAQMAKKGNQGGRTVEGTESGQEEQRNGLRKSSKDHKTGHEESSTSSTATQGASANERTHPTGEQPNESADSGDKCTVKTEAEGSSGVSCISGESEIPNAAPDAAAANDLDFDLSSDSESEGKMVLSDSDGEGKTADTGKPKQRKNEECKSKEDDGDKQRTEGGDDPVTDPEGLRDLGNGCSDKKEMETESQNSEQSGVTMGEESLDHSMEDEDDEEEEDVDQDDHLIYLEEILVRIHNEYYSRYEAFLKKESSESPDIRKIVPELKGRTLAGTTVIFSGLYPTNYPMERTREWYHGKALGAKLCKTLVLNAKDPNRTTHLIAARAGTEKVRQAQGCKHLHVVNPDWLWACLERWERVEEQLFPLKEDYNKSHRSNSPGAFLDIHGSAPRPPFQAPQVQPKPLPAPEMRTYDPVTGKLIRRGPQASRPPSYLHSHPSSSMSAKGDLSNLRSAQGSQQTDEPAGSSPDDEQPGPSRRKRQPSMSETMPLYTLCKEDLDSMDKEVDDILGEESDNESEGKGKAGRIEEEEEEVRPHTSKQKPPATDHIPPLAAVVEETSQTSTSEVCVTENVLRGHKRKLEEAREDEDKDEEDGDSSKDSNEDEEGSSSEADEMAAALEAELNDFM
The following text describes a protein:
Function:
Involved in the clustering of telomeres at the nuclear periphery, forming discrete subcompartments that accumulate a complex of histone-binding silencing factors like SIR4. Required for SIR4-mediated anchoring and partitioning of plasmids.
Subcellular Localization:
Nucleus. Note=Concentrated at the nuclear periphery.
Sequence:
MSKKKETFTPRANKLKLTTPRRKLKILSSLLDADEDSKMKDQHGYSRVHNDKYRVAKPTQHSTLHESISSRRSSHIHNKSLHEDSARALSWVDSLINRGKSILTTLEKEDALFERSLEEERQRFQLHDSLMNKYTGNSKSHQRLIDLRKSQYGTDTSFQNNDEIPLDSFISSPLPDAEDESSSNIDSDKDEDLEGKQSLIKDFDLENDEYELSEEEKNSDGQSSPSIMILSDEEYAEEGALQDVSNDEYAEEEGQVERKNIGQEQANVENATQISSSDSSEGQNYSEGVEMELEDDIDVESDAEKDESQGAEGTEHSVDFSKYMQPRTDNTKIPVIEKYESDEHKVHQRYSEDGAFDFGSVNISVDDESEDEESQAESYSANAENVYHHNEHELDDKELIEDIESSDSESQSAQESEQGSEDDFEYKMKNEKSTSEETENTSESRDQGFAKDAYTKNKVEQQENDEEPEKDDIIRSSLDKNFHGNNNKSEYSENVLENETDPAIVERENQINDVEGYDVTGKSVESDLHEHSPDNLYDLAARAMLQFQQSRNSNCPQKEEQVSESYLGHSNGSNLSGRSLDESEEQIPLKDFTGENNNNLKTDRGDLSSSVEIEVEKVSEKKLDGSTEKELVPLSTDTTINNSSLGNEDSIYYSLDDADAISENLTDVPLMEIKTTPKYEVVISESVYSSTSYEDNTVAMPPQVEYTSPFMNDPFNSLNDDYEKKHDLLKSTLAALAPAFTKKDAEFVEAGVTKSCLTSTSGHTNIFHTSKETKQVSDLDESTENVTFENENTGDENKNQSKNFPGVANSTDKSTEDNTDEKYFSAINYTNVTGDSSCEDIIETASNVEENLRYCEKDMNEAEMSSGDECVKQNDDGSKTQISFSTDSPDNFQESNDNTEFSSTKYKVRNSDLEDDESLKKELTKAEVVDKLDEEESEDSYEQDYADPEPGNDEGSNENIVKGTKKDTLGIVEPENEKVNKVHEEETLFEANVSSSVNVQNKDMHTDVINQEAQANYEAGERKYYIQNTDTEEAHISIIERIDENAIGNNMEIPERSCVEKTHNEVLFERRATTIENTKALENNTNMHDQVSQACSDSDRDQDSTAEKNVEGSAKHNLDIRVSSSEIESVEPLKPESDRSNIFSSPIRVIGAVVKGVGKVVDVAESFVKKIDVMDSESDDNVDIGDYNQDIFNKSNSTDASVNMKSVSSKERDSDEDEAVILGGVTAEAHNDNGNNSRVINIDPTTNGAYEEDSEVFRQQVKDKENLHKSEEPLVEGLQSEQHFEKKDHSENEEEFDTIYGDITSANIHSNAPDDIKRQQLLKNLSDLENYSQRLIEDSRRGKNQEESDEVNTSRERDLTFEKSVNEKYAGAIEEDTFSELDISIQHPEHEEDLDLSNNQERSIEELNSEPEEAELYELEIEGPTETAASSKMNDDERQRGNIPSTDLPSDPPSDKEEVTDSYPYSNSENITAEKSAPTSPEVYEIFSDTPNEVPMEINDEIPATTLEKHDKTNVTSVLDDRSEHLSSHDVDNEPHDNSINIKVNEGEEPEHQAVDIPVKVEVKEEQEEMPSKSVLEEQKPSMELINDKSSPENNNDEETNREKDKTKAKKKSRKRNYNSRRRKRKITEGSSAASNTKRRRGHEPKSRGQNTHPSVDK
The following text describes a protein:
Function:
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MFRRVVPSSSSSAQNGDMLRRVTTSSPLIRDDYIPRTVEHIFINYRLRRVGMLRAFGTDVGTLYNLCDPGYKENLSLYGYPDGTWDVQEARMLLPPNLPEPTVGINLARDRMRAIDWVTVVAEHCDSWLLSLAFLFGVGLSHDDRERLFERINGLPTLAEKVKEYYPGQLIQSRIQQANLEN
The following text describes a protein:
Function:
Probable thiol protease.
Subcellular Localization:
Lytic vacuole. Note=Predominantly vacuolar. From the Golgi apparatus, probably transported to the lytic vacuole (LV) in clathrin-coated vesicles (CCVs) via the prevacuolar compartment (PVC).
Sequence:
MDYHLRVLFSVSLIFVFVSVSVCGDEDVLIRQVVDETEPKVLSSEDHFTLFKKKFGKVYGSIEEHYYRFSVFKANLLRAMRHQKMDPSARHGVTQFSDLTRSEFRRKHLGVKGGFKLPKDANQAPILPTQNLPEEFDWRDRGAVTPVKNQGSCGSCWSFSTTGALEGAHFLATGKLVSLSEQQLVDCDHECDPEEEGSCDSGCNGGLMNSAFEYTLKTGGLMREKDYPYTGTDGGSCKLDRSKIVASVSNFSVVSINEDQIAANLIKNGPLAVAINAAYMQTYIGGVSCPYICSRRLNHGVLLVGYGSAGFSQARLKEKPYWIIKNSWGESWGENGFYKICKGRNICGVDSLVSTVAATTS
The following text describes a protein:
Function:
Component of the tartrate utilization system and may allow entry of tartrate and tartrate dehydrogenase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSTASTLNSTTLPLSDSTHDRVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDALGLRGWQWMFLIEGLPVVLLGVVVWCSLPESFERVTWLSDEQKHLLREELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTTQSASLALYLLAILIALGAGLVLRTPAAVVNPR