lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in regulation of the cell cycle. Required for mitotic cell division and cytokinesis. Based on its localization to centrosomes and spindle microtubules, as well as to various cytoskeletal components such as the median body, parental attachment disk, and anterior and posterior-lateral paraflagellar dense rods, may coordinate reorganization and segregation of tubulin-containing structures during mitosis and cytokinesis. May regulate microtubule disassembly by phosphorylating cytoskeletal proteins leading to their destabilization. Phosphorylates EB1 at 'Ser-148' in vitro. Phosphorylates histone H3 in vitro.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Nucleus membrane. Note=Non-phosphorylated form is exclusively localized to both nuclei in interphase trophozoites. At the beginning of mitosis, it is mostly in the nuclei and co-localizes with chromatin through telophase. Phosphorylated form co-localizes with centrin to centrosomes from prophase through cytokinesis. Phosphorylated form also localizes to the spindle microtubules surrounding each two nuclei and the spindle poles in metaphase. It is additionally dynamically localized to cytoskeletal structures including the median body, rim of the attachment disk, and anterior and posterior-lateral paraflagellar dense rods during different stages of mitosis. Phosphorylated form remains localized to microtubules of both spindles in anaphase through telophase as the spindles elongate to allow the four nuclei segregate to opposite poles of both spindles. Phosphorylated form localizes only to the gradually unfolding parental ventral attachment disk called pontoon later in telophase and cytokinesis, but not to the two nascent daughter disks dorsal to the disassembling parental disk and spindles. Phosphorylated form localizes to the median body in all stages of mitosis, but it is less prominent after anaphase. Neither non-phosphorylated nor phosphorylated form localizes to endoplasmic reticulum, lysosome-like peripheral vesicles, mitosomes or flagellar axonemes. Colocalizes with EB1 at the nuclear membrane and median bodies in interphase, at the spindle microtubules surrounding the chromosomes in metaphase, at the mitotic spindles in anaphase and telophase, and at the nuclear membranes in cytokinesis.
Sequence:
MPQHLVPHTGTGKRTTIEDFEIGRFLGRGKYGLVYLAREQSSKLVVALKVLYKSYIKSERVEGQVRRELDIHLNVRHINIIRLYTWFQDETRVFLVLEVAPYGELYQRLQQFGKFPLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILICKGKETKEHTDAHNSDDSISVHEHELVRMAHYTYKIADFGWSVHHPTHGGRRRTQCGTLDYLPPEVMLGQSYDKACDIWSLGALCYELICGTAPFYHDEIKITRQNIANVEYSFTKDFSPASKDFIQRMLIRSPEARISIEDILRHPFLRQTDHRSKVPK
The following text describes a protein:
Function:
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. May be involved in transport from the vacuolar compartment to the cytoplasm.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MPVSRIAVGSHREVYEVGALKAALAEFISTLIFVFAGQGSGMAFSKLSPDGAATPAGLISAAIAHAFALFVAVSVGANISGGHVNPAVTFGAFVGGNITLFRGLLYWIAQLLGSTAACFLLRFSTGGLPTGTFGLSGIGAWEAVVLEIVMTFGLVYTVYATAVDPKKGSLGTIAPIAIGFIVGANILVGGAFSGASMNPAVSFGPALVSWEWGYQWVYWVGPLIGGGLAGVIYELLFISRTHEQLPTTDY
The following text describes a protein:
Function:
Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1.
Subcellular Localization:
Nucleus.
Sequence:
MSNNPHRTHKRQKSSVSNPGYYFTPETKSEIQQQQPQQQESQQQQQQQQQQHSQTHNIYDNDNYMNYNFPPTSNRPRASTTTGTTSTTHPGSELSHESHSVHTSPLKRTASSELDQPIPAMAPSSPLVSSAPYYYQQPSQQQNLSYHDHHHQQQQQQSTPQGQQLSQQTQSNSQSGVPPPLYGTSSSIPPGSTMQPSTSFAFHTSHSTYNPSFDSSNLYNSAFRLPEYPTTSSSSLLSTTGGKQFQQSSALLPSGTLPPSILGTSSSSHVSALRQHQKNNLSISSHLTLFSLSGNNSSQLQSQGSSFQQSETGVDDTKRSSKESTTIFNDLLFHLTSVDGSNINTFLLSILRKINSPFTLDDFYNLLYNDRQRTLLDNSNYQNRIDKTIVSPSDTDMTVSIINQLLNFFKTPSMLVDYFPNMEDKDNKLANINYHELLRTFLAIKILHDILIQLPISEDDDPQNYTIPRLSIYKTYYIICQKLIASYPSASNTRNEQQKLILGQSKLGKLIKLVYPNLLIKRLGSRGESKYNYLGVMWNANIVQEEIKQLCDEHELNDLNEIFNSDNNNPFASIAPSGSATTGSTPRRGLSHKRTSSKQKIKTEPVAGNPFLQPLQTSHHHHHSHHHHHEEQSQEESLSQQMGEHITAPRLSFLRANSKYPTDVNLSVLDDDNWFVRLSYECYARQPALNRDLIQQIFLKNEFLLNNSSLLQNLMDSIIKPLVMQETYSNVDLVLYLAILLEILPYLLLVKSSTNINLLKNLRLNLLHLINNFNNELKKLDSPKFPIERSTIFLVLVKKLINLNDLLITFIKLINRDNCKTTMSSDIENFLKINSQTVKLDDDDNSFFFNLNTTSMGEVNFNFKNEILSNDLIYTLIGYNFDPTTNSELKSSISMNFINEEINVIDEFFKNDLLNFLSTDFHAGLDDDNGEEDDDEEAGPGSTHPMGATGSQGSLSPEPVSTGNPSVPPTRNTSISEVNAENKRGNEAVLTPKETAKLNSLISLIDKRLLSSQFKSKYPILMYNNCISYILNDILKHIFLKQQQQQLQSSSSQLHDTQPLTQQDTAQGIGSSSSNANNTNSSFGNWWVFNSFIQEYMSLIGELVGLHDNLV
The following text describes a protein:
Function:
Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals.
Sequence:
MRSKFMSSPTLSDLGKREATAAAALDERGTQQKRAGANATWNSIQNGVISVFQKKGLADHELYSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDILPMLQAIFYPVQGKEPSIRQLALLHFRNIITLNLKLDDALSRPRARVPPSIIQMLLILQGVHESKGVTEEYMNLESLIQKVVSPYLGTYGLYSNEAPFCHSSCILEKRMFRRCPKSGEILTKNPVVRSKSYNNPLLTPVAEYEMENLVANGSGIRRHSVSEMTSVLELPMGYSNLTTDSTSKLSMAGTKPPGEGERPPISNGQFPPLHNLSDSQQGLYNSQRDSPLLPAPSSSPETIVDQILESIDSDSEGIFIDFGRGCSKSPEFSMEIGRQSLV
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Functions with WRKY33 as positive regulator of salt stress response and abscisic acid (ABA) signaling. Plays a partial role in heat stress tolerance. Functions with WRKY26 and WRKY33 as positive regulator of plant thermotolerance by partially participating in ethylene-response signal transduction pathway.
Subcellular Localization:
Nucleus.
Sequence:
MSSTSFTDLLGSSGVDCYEDDEDLRVSGSSFGGYYPERTGSGLPKFKTAQPPPLPISQSSHNFTFSDYLDSPLLLSSSHSLISPTTGTFPLQGFNGTTNNHSDFPWQLQSQPSNASSALQETYGVQDHEKKQEMIPNEIATQNNNQSFGTERQIKIPAYMVSRNSNDGYGWRKYGQKQVKKSENPRSYFKCTYPDCVSKKIVETASDGQITEIIYKGGHNHPKPEFTKRPSQSSLPSSVNGRRLFNPASVVSEPHDQSENSSISFDYSDLEQKSFKSEYGEIDEEEEQPEMKRMKREGEDEGMSIEVSKGVKEPRVVVQTISDIDVLIDGFRWRKYGQKVVKGNTNPRSYYKCTFQGCGVKKQVERSAADERAVLTTYEGRHNHDIPTALRRS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MIIKKKKDWRTQLFNRSQKKTIERMRKERNNQSVEMDSHTFNNNNNNNNNNNINNNNNINNNNNNNNNNNNNNNSINNYGHQHLNSSSSSQSFQDQLVQDLQSILMAQQHNIISPQLQQQQQQQQQQQPSFNSNNNNNNNTNTYNFQPEAIENNNIGINSNGYNPIQQQFQQQHQLQQQIQQQQIQFQNQNQNQQTHQNRQLQQQQQHQIQQLQLQQQLQQQLQQQQQHQQQLQQQMQHQQMQQQQIPHHQQNQQLQQQQQQQVPHQQQNQLIQQQQQQQQQQQQQQQHQQHQQHQQHQQQHQQHQQQHQQHQQQHQHQHQQQHQQQQQPQNQQQQQPQNQQMQQQQQQNQQMQQQQQQNQQMQQQMQQQQQLQQQQQILQQQQQIQQQQQQQQQILQPQQQPQQQQQQQQLLQQQQQQQLMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQIQQQQPQQQPQQQQQPQQQQSQQQPQPQQQQQQQQQQQQQQQQIQQQYVDDNGDNTLLIFISNMCRNVEIPAFSVQPDQYYQYFVEKIVVIWSDLISSSGSTKMTHEETQQQKSSLFEQCRRIIVTYPHFFNQIITERFIFDLEDLNSKISDIFKQFNNNNNNNNNNAIENSPIMAEQYKRFQTDYIIKFDQLQCFKFPDYSLSSIISTLNPSPLRQQQQQQQQQQQQQQQQQQQQQQQQQQQIQIQNQTIPIPPSPQPTQQYQPITQLDQQPQPQPQPQLQQQLQQTILDNNNNNNTNNTNNTNTINNNLDISNDIINSSNNIGLCSSPISLENEKGNNNNNNNKINNNNNTSSSSSITIPINNTTSSPINKNINDDINNNNNNNNSNNNNNNNNNNNNNNNNNNTNTNNEIKKTNNDISTNLSMPTVVDLNSSNNITSSTFLLNPNINNNNNNNSSGGGGSSSSSNSNSSSPNIPNKPKKPVKSNSKKVIDLLEDNDSDSSDSSDSSDSSDSSDSSDSSDSDSSDSSDSSDSSDDEKKKKPKKPIVNKKNLVKTNTSTNSKDSKPASTATSTTTTTTNSKPSITQPTSKIKPSSTIPSQPTSITTKKKPENSTTSLPASTSSSSPSNTVIKSSPPISKTLPTPTSTTSLSSSSSATVNKPIPPTTKKPISTINNNTLNNNTNSSINKIASNSTSTLGNKNLGTPSNYNNNNNNIGAEKKKEKALTLTESQLTNEKELPSLTDYIAQLNKIKKSNTTSGVTNSNNNNNNNNNNNNNNNNNNNNNNNNNKGTTTSTTTVINDPNKKKISWKDEKGGCSVVDRVPMFIQEFSECVTWPRIREFLIVIDSKMSNACKKRFLELGGLANIHTVLKYSQETVTIPRDTIIALKGLKGLPVTVEHLHAEKLIGKTIRSFKKHSNPNVKEYAEELESEWMYLIKGGATSNTSSTTSSASSSSSSSISNGNNSDKKRNRDQPITDTSKKLKSSSSSSSSSSSSSSSTNARSSSPVPNTQLPPKKSIIKEYDDLFMNKLSTPSSSSSSSSSSSSSSTTTTTTSTGSTIPLSPPPSSSSSSNNNNSLSPIMTFKTKQSIAAAAAKKQQTQELSDSTAKSLSSNGATTKLFAAMVDKKSQTKPGGGSGGSSNVSGKSDSSQTLLESIGISWDTPTKEEEDLTPVPDPNRRKSSKGKVSVKWLSDEKLVNVKEFCKEEIADAKANEEYELEQSKRFELETERLLGFKPMKATLEWKKPIPIEDTQLPDIKLYGSESLEKDIQFERENFTLMEFYIGSNIPDTPKEPDDEQKDYDDKDVLIIPSGDINDVFDDSKINELMNVIPPILSDQINDDNIINNNNNTHSNSPDENNTKMINDENNDPNNTGSSNKVVEMIANIDPNNNNNNNNINNNNNIINNINNNNNNNMNNNNMGNMNNMGNMNNQFNNMNNNNNNNQFNNGYNNNNNNNNNNNNNNNNNNNNMMGYNNGYNMNNGNQFNNNYNGVYQNNGFNNFNNQYNNGQYNGYNNSNGQFNNNNNNVYNNNNNNQFNNNFNQYNNNNNNNFNQNFNNGFNNNNNNNNQYNNGYNNFNNNNNYGNMNNYNNNNNNYYNNNNNNNNNNNNNQSYS
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MARIDLVDLAHSYGGNAAPQESFALKPVTMTWRQGGAYALLGPSGCGKTTLLNVISGIITPSRGKILFDGVDITPLSTQKRNIAQVFQFPVIYDTMTVGENLAFPLKNRGVPKAEIDRRVAEIGRLLDLDPYLNRKATRLTADAKQKISLGRGLVRNDVAAVLFDEPLTVIDPELKWQLRSKLKALHRELDLTMIYVTHDQTEALTFADTVVVMHDGRVVQSGTPAELFDKPAHTFVGYFIGSPGMNILPAEVRGREARIGGNVIALGRSYDNLPAGAKIEIGVRPEFVDAVAPAPGLLTAKVERIDDLGRIRFARVRIGEAKIAARAPAGFTSADGTAGLKFDPSHVHVYADSLLVEGAA
The following text describes a protein:
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Sequence:
MSKLKKTDGKYLWWCLLCLKFKPDNVSVTKTTKHLNLGMNMFDKPNKEAFYIVIHFLFNKLNPTRAQDVFRNCWLVWDHKSDAEFRKVAFAWLQEIANEEGSAFPKVAASHLLSAFGPKFINLMLHLAKHVMLKTMKTFNTDGMWVPEAAAVPASSEEMELKRFQLVKRQFQRVTVEQDFLIQDYQKRAKVLEKSLRDLDAENAKYDSLLKEHDSITDLKEVILAKVQKLRGLWNEVDRFLSNHQGKRDIVASVINGQVDQYILCGQELNVKMPAALRERMERPSHQSSAVRLYEGGQPVLVRLLALLNEGLHVLREEREKIVGPSVQLQNQDVQEHALLFTRSKENLNLIRWKLVKEDAAEIKVSIGKLEEEWECKWANCLKNTPLTCFLEEDPVLDLVSPMVALSFEPASEASFQASVISQYPCKPHDLLEQPSKEKLDTTVAVVHLEQEVHLKPEIKISSVATEDQDVLVPSDSCFSPEHVTCGTPPCETILSVIETPSPKQPCHTNLHSKPKASVLKTKAQILDLECDNLASQFADAVIMSPGNQRSDVDLGQLLNAISDPFSSRKQLCRTPESLIKDVRSSWRKAVEEGLAEKKQASWNQQDSLSWLKTPMANMNSPCKTLNLESSMSFSTNLDNCTSPPVQQGSTLHSTLSWDSSQMEVLTSQCSSDVIKFSIAQEEPPDLFDVSFNSDSSVENSGEKARDEELCLPSVGLCYLDETPQLTEQLCLGASSDKSVFKDSPVHLSMSKDLSHWTTDHFSLDLDRLESLSSPPRAENLTLPNLVNVNLDEY
The following text describes a protein:
Function:
Cytotoxin and helminthotoxin with ribonuclease activity. Possesses a wide variety of biological activities (By similarity).
Subcellular Localization:
Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
Sequence:
MGLKLLESRLCLLLSLGLVLMLASCQPPTPSQWFEIQHIYNRAYPRCNDAMRHRNRFTGHCKDINTFLHTSFASVVGVCGNRNIPCGNRTYRNCHNSRYRVSITFCNLTTPARIYTQCRYQTTRSRKFYTVGCDPRTPRDSPMYPVVPVHLDRIF
The following text describes a protein:
Function:
May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Sequence:
MHAGGKYCGPRHCSFYIIAFLICQLFFLVIFIRNDDASSANELLSFMNESEESDHLDWRVFISHTPETSEDFYQYNIHLSNALGLIRKLPVTRHHSCTTRNSILPAPLEANVSVVISFHNEARSMLLRTIVSLLSRSPEDYLHELILVDDGSQRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERMGLIWSRNRGASLASGRYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYRKGNELLKGGFDWSLHFHWLKRQLTNQESLEMPYQSPAFAGGVLMMSREWFLKLGSFNPYLKIWGGESIELAIKLWLCGGQIEIVPCSRIGHIFRRRHAFDFPPQSDRQLSPAQETYLHNSKIIAESWLDEYKNMFYALRPAARRIPLDHTYDELQRMRKERRCHPFEWYLRHVSPELRMHFDELSATGTLRNEDRCVHARQKDSQPILASCYLSDITQWSMLRQSGQLSTHRELCLAVGFGMRIALEPCGRNETVRRSQRWVRLGTHLLHAESHLCLDNPLKDRLEMSTCRSHAVSQSFQFALEMEGQT
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. May function in a signal transduction cascade during early development.
Subcellular Localization:
Nucleus.
Sequence:
MSMFWGLNMKPERKYSQTIIKSFHISGVALDKGQEAKLYLAAEKQEYIVATVTKAIPQVALDLNFSKGDRIMFYTAGDASVSLLGYLHDIDSEDDEDDDQMTIENLLNSKAIKNSKKSEDDEDENESGEEDEEDTDDDSQIIEEYESFLENGEEEDDDDVDEDNEESGEEDEQDSDDSEAEEEQPKAKVAKLSPGASAKKSGKEQNGVAKKEEAKQQQKKKEKPEAKKEQPKAKEPAKQQPASKDPRTITGGVKIVDQVVGKGEEAKQGKRVSVYYIGRLQSNNKTFDSLLKGKPFKFALGGGEVIKGWDVGVAGMKVGGKRVITCPPHMAYGARGAPPKIGPNSTLVFEVELKAVH
The following text describes a protein:
Function:
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.
Subcellular Localization:
Secreted, cell wall. Secreted, extracellular space, apoplast.
Sequence:
MPESLSKREPKLSTASPVPWDQNYMNLYTPVPNDGLAISDDGMDASLKITGTNQSFGHFQSKNRFMFGYFSMFIKLIPNESAGVIATYYFSSPETKNQRHHYLKFDPTADFHKYSLLWNQHLIIWFVDNKVIRVFHNVSNETGVPYPVGKPLAIQCSIWDGGEWATQGGRVKLNYSYAPFVVHYEGFDGVHGCQACPASPVTACDNKTEFPECYDSDKYWFLHQEEPTKRQIEQLKKHHRKYIVYDYCQDRMRFPSGLPDECQFNSY
The following text describes a protein:
Function:
Involved in regulation of the growth and differentiation transition (GDT) process, probably by regulating gene expression via histone modification.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MYQGKGTYLENYLDSISTLPSELGRNFALIRELDYRTSDLVEKIEKLKSNLLVTTNGTRRAVHELTDERASKHIKLEMKQVIEYSDEKVELSNQTYELIDKHIRKLDIDLKKFETELESAEEEKKKKKSKQSQNNSTVESSTTSSSSSSSSSSLSLSSSTNNTSSLNSSSGGGGGGSGGGGGGGGHSSHSTGNKKGKARDSLTSSSSSGNINGMSSSSSSSSSSSSLSSRKQKSMAAQDIASITGNNGDADVRVFNANPNDLDLAIDPNEPTYCFCNRVSFGEMVGCENPDCKIEWFHFECVGLTSTPKGKWYCPDCTRIKVKK
The following text describes a protein:
Function:
Molecular adapter that is necessary to a form a stable 2-oxoglutarate dehydrogenase enzyme complex (OGDC). Required for incorporation of the E3 subunit (dld1) into the E1-E2 core (kgd1-kgd2) of mitochondrial OGDC, and acting as a stability factor for the fully assembled complex.
Subcellular Localization:
Mitochondrion.
Sequence:
MVRKILIDFTKHITKSSLERHPHPAASFPLPASFTTVDSGPAKHSTAPPATPETSILVEDRNELPLRFHRLPVSEAEMQAVESGGAYAF
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MGAVGENNVRGRKKSSSRGHHRFVGVRQRPSGRWVAEIKDSLQKVRLWLGTFDTAEEAARAYDDAARALRGANARTNFELPDQTQTHSQLSNSNNRFLADIINNNNNIEPFSFDQVCGSGNEADGLLGALKAKLFDFDGSTNTVTAVVLPQPQTQPQPPNNSTSGVAYTATTSTNNSSSIVAVPPREEVGLLLVSGNNNSNNCSIINSSGWSAAVAAAGKVDHHLIVDHQVVAAAGHAYNVGLQCQWHHPNIPPAQTSSTTNMVWSTTEPTAGYEVSWSTQMNRALSPENIPLVTSTSVATTTAASTWPVSSGLTSNSTTVDFSFSDHYQSAKMSTVSVGMPMTQIHGSTTEGVCSSDQQFLHFENKAWTASAATPASWDPLLYMSSPLC
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MEIQFQRHDTYHHPQPQQKPLSPIRKTKFKSTPSNNTAKSKFVGVRQRPSGKWVAEIKDTTQKIRMWLGTFDTAEEAARAYDEAACLLRGFNTRTNFSPHLPTSSALSLKIRTLLNQKISSRRDRPMVSHSNSKSTKKPASQTNSATSISSMISLSSVTNVYTSSDSDCSFSSGMMQDGRIFDDAYRPDLSRCLASLGSTPMSQHNHSWAFTSGLDHLPLVQEDGLPKHGPCASTTDLELSEFERMKVERQISASLYAVNGLNEYLENTYNSNETMWDIPALSQLFCHS
The following text describes a protein:
Function:
Protein phosphatase which antagonizes mitotic cyclin-dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintained to facilitate completion of cell division in response to minor perturbation of the cell division machinery. Inhibits transcription of ribosomal genes (rDNA) during anaphase and controls segregation of nucleolus by facilitating condensin targeting to rDNA chromatin in anaphase. Dephosphorylates SIC1, a CDC28 inhibitor, and SWI5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of mitotic cyclin degradation, CDH1. Dephosphorylates the microtubule bundling factor ASE1 which is required to define a centered and focused mitotic spindle midzone that can drive continuous spindle elongation. Dephosphorylates the anaphase-promoting complex inhibitor ACM1, leading to its degradation. Facilitates INN1-CYK3 complex formation which promotes cytokinesis through the dephosphorylation of CDC28-phosphosphorylated INN1. Also reverts the inhibitory CDC28 phosphorylation of CHS2 for endoplasmic reticulum export, ensuring that septum formation is contingent upon chromosome separation and exit from mitosis. Additional substrates for CDC14 are the formins BNI1 and BNR1, as well as CDC6, DBP2, DSN1, INCENP, KAR9, MCM3, ORC2, ORC6, SLD2, and SWI6. Activity is inhibited by interaction with NET1 which sequesters it to the nucleolus.
Miscellaneous:
MISCELLANEOUS: Present with 8550 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Bud neck. Note=Sequestered in the nucleolus for most of the cell cycle by the nucleolar proteins NET1 and TOF2, and is released into the nucleus and cytoplasm during anaphase. CDC55 maintains CDC14 sequestration in the nucleolus during early meiosis, which is essential for the assembly of the meiosis I spindle. In anaphase, the CDC14 early anaphase release (FEAR) network (including CDC5, ESP1, and SLK19), and the mitotic exit network (including the DBF2-MOB1 complex) coordinately trigger the release of CDC14 from the nucleolus.
Sequence:
MRRSVYLDNTIEFLRGRVYLGAYDYTPEDTDELVFFTVEDAIFYNSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANAACMLCCYMILVQAWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTPDFIAFASPQEDHPKGYLATKSSHLNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQNDFREWKYTTRISLKPSEAIGGLYPLISLEEYRLQKKKLKDDKRVAQNNIEGELRDLTMTPPSNGHGALSARNSSQPSTANNGSNSFKSSAVPQTSPGQPRKGQNGSNTIEDINNNRNPTSHANRKVVIESNNSDDESMQDTNGTSNHYPKVSRKKNDISSASSSRMEDNEPSATNINNAADDTILRQLLPKNRRVTSGRRTTSAAGGIRKISGSIKK
The following text describes a protein:
Function:
Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
METGMNRKRSRSKRANSNVGVEKDKEKEKSKGVSNVPNEVETESSSHEPSFKKDVDEEIPSLTAELSEEEEGEYSSESGRSTPELSPDDFEDADDEEEFEEIDAGYSSDSSTEDVAPGLYESPYDENLYINYDIDGKKITRPATPAALDSLIASIDKDKGWTGIVDPMTGKPVNLTTEELGLLKRLAQSEIPDENFDPYPDYDDFFTNTVRETPLSSAPEPKRRFAPSKHEQKRILQLAYAIRKGRILTSEQRAERERESQSNYADHDLWADDDQATVNQRKLDYAPAPKLPPPSHEESYNPPEEYLKQSSDFPKKYKSLRVVPAYSNLIKEKFERCLDLYLAPRVRRTKLNIDPESLLPKLPTPSELRPFPTRCTNVFIGHKGRVRCLSVHVSGNWLASGGDDGVLRIWEVMTGRCVWKCSLDSFGNAHNIDSDEDAVNESLSHSTKSSIIQSLAWGPLSDSPVLAVAVDETVYFITPPIFSDEQIEASKELFTSAPYQESSAIWRRGAKQSLQLHGGIVHATVSTPSSIKSLSWHRRGDYLATSSPTSSSQAVLIHQLSRGASQSPFSKSKGSVQAVTFHPTMPYLLVATQRYVRIYNLVKQELVKTLLTGVKWVSSLSVHSSGDHVIIGSYDKRLCWFDLDFSSKPYKNLRYHSRALRDVSYHPSLPLFCSGSDDGDVQVFHGRVYSDLLANPLIVPLKILRNHKVVDNVGVLSTCWHPKEAWLFSAGAGGEIRMWT
The following text describes a protein:
Function:
Transcription activation of the irgA gene. In the presence of sufficient iron, transcription of both irgA and irgB is negatively regulated by a fur-like protein. In low iron conditions, negative regulation of transcription is removed, and production of irgB leads to positive transcriptional activation of irgA (By similarity).
Sequence:
MQDLSAVKAFHALCQHKSLTAAAKALEQPKSTLSRRLAQLEEDLGQSLLMRQGNRLTLTKAGEVFAVYSEQLLELANKSQEALQELNNQVTGELTLVVHPNLIRGWLSQVLDEFMQQHSTLKIRLLSQFQHSDEVFEPDLIIWIEHAAPMGYRKERLGYWRYAAYASPKYLAHRDKPTHPRELIHHPWIDFIACRRAELELHHPEFGSYSLPALESRLQSDNLAMQADAIAKGRGIGLLPTWFANGFETAHPGSLIPCVNGWQSQPTEINCFYPLGRHPLRLRLFIDALRQARPDEWQ
The following text describes a protein:
Function:
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Subcellular Localization:
Cytoplasm.
Domain:
The PRC barrel domain binds ribosomal protein uS19.
Sequence:
MSKQLAAQVPAEPVVLGKMGSSYGIRGWLRVFSSTEDAESIFDYQPWFIQKAGQWQQVQLESWKHHNQDLIIKLKGVDDRDAANLLTNCEIVVDSSQLPALEEGDYYWKDLMGCQVVTAEGYDLGKVIDMMETGSNDVLVIKANLKDAFGIKERLVPFLDGQVIKKVDLATRTIEVDWDPGF
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MKIAIIGAGALGSVIGFHLAANHAVTLVDPWEEHVNTINEYGLRCSFDDQEQVRLLPATTSADNLEPVEVALITVKAAQTPWAAEIAAQIVQPNGVAYTLQNGLGNAERLASRLGTQRVGQGVTTIGATLLAPGHVRMAGRGPTTFAATPSLQLAYAVADAFRASSLPAGVSTDLASLVWGKLIVNTGINALTALLRVPNGALANIPAAEKLVRRAVEEAVAVACAAGITIGLSDPVAETLAVARATATNRSSMLQDVLRGAPTEIDTINGAIVREGQRLGVPTPFNAFLCDLITALEATTPLRVK
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTSERVESVLELITYTKGVAGAVVCNRNGEPIRDSFQDLDRNRAVAYSNMAADLARDAALLFSADESLDAVRVRSLNNEIIIKCHEEFLLVVIQELTK
The following text describes a protein:
Function:
Involved in peroxisomal proliferation. Could participate in peroxisomal elongation or fission. May be involved in parceling of peroxisomes into regular quanta.
Subcellular Localization:
Peroxisome membrane; Peripheral membrane protein.
Sequence:
MVYGELIYHPVVTKLLKFLDSSASREKLLRLLQYLCRFLTFYTFKRNFNIETIQLIKKIQSSIGISRKPLRFLKNLPHLKNLNKIYSNELLDSTLKIGDLIKNFGYALYFQFDTLQWLKLLGLLTSKNSGSLYFKIDKLAANFWLIGLTGSIITDLRNLKISYDSNKALLNEINSQNNNSNNDTLDEKLIEQNNDLILKNNEKINLNKRDLFKNILDSLIALKGSQLIDLNDGVLGFAGIITSIIGIEDIWNATKA
The following text describes a protein:
Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.
Subcellular Localization:
Nucleus.
Sequence:
MAANVFPFRDARAAPDPVLETGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSLAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDVQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALNHLDDNEVWITRKEYEEKGGEYLKEHCASNIYVPIRLPKQASRSSDAQASSKGSAAGGGGAGEQA