lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters; Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
Subcellular Localization:
Endoplasmic reticulum membrane. Microsome membrane.
Sequence:
MTKKRIAVIGGGVSGLSSIKCCVEEGLEPVCFERTDDIGGLWRFQENPEEGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNAQVLEYFRMYAKEFDLLKYIRFKTTVCSVKKQPDFATSGQWEVVTESEGKKEMNVFDGVMVCTGHHTNAHLPLESFPGIEKFKGQYFHSRDYKNPEGFTGKRVIIIGIGNSGGDLAVEISQTAKQVFLSTRRGAWILNRVGDYGYPADVLFSSRLTHFIWKICGQSLANKYLEKKINQRFDHEMFGLKPKHRALSQHPTVNDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSREDDIDAVIFATGYSFDFPFLEDSVKVVKNKISLYKKVFPPNLERPTLAIIGLIQPLGAIMPISELQGRWATQVFKGLKTLPSQSEMMAEISKAQEEIDRRYVESQRHTIQGDYVDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSMTSTMTIGKFMLALAFFAIIIAYF
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MDKNQTQGDLACPPRMELEEIASKINDLDKWRSIFSSQGLEVSKAMIQKTQENLKADEESEDKSETLSIKKHGYFPSNILYSIPKEFIVAADLGGQPISIEMAVELKKILFGNTFYTFNYEWKKSFFKFCNPFTNMAYSLEAEKTGTRAIQMAVQGHIIKYLLFTKNGDEHSSLQNLQELSQKQQEKALAAALADILWTAGERNKATICLITNDPYFTQGPDYKADNFTERLQLFEFVDKEILEKFLCAHIYCFKNDGCHGVILFLYSLLFSRTLLRLQDDLDITTTHLLQFSLGNFSARQALINLMLTGRASPQVFNGDQVSDEGNTEHQARHGVLVRSDVGFLHWSREEMQQDRLPRVGSMLKTPKFPIWLCNINGTYSVLFGTNMSLLCDWKMEHFFDLYFYNGQLSQSKTVHLTIDTHSHHWEEQSKADEGDIEKRFPSVEMTVRTKWDGAAINWHGTVPFY
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MALKKMPPKKPYHQKASKTKACYNCHRKRLRCDKSLPACLKCSINGEECLGYGIVLRWAACNSPTSTITTRTTNKTNFNGTNTTTPRTVKSSTPTQAPTPSDSPRQLDTDVTSSSAPSHTCSRSTTTSTTTTRISSPTLEETIDSFTVETPIDNNVDPLPRAPDDNPDPSSQIIKRPVNLIKIPLTDPLLNGLSTKARWYMHHFATIVCRDLVSIDQKERNPFRAIIPLVRKFDYLQSVVLATAAMHLSTIHKYQGRSLPSESALVDALMLKSRALHLLRAAINDNTLTDKAMILSAIVFLVNLDLIDSGRGGWKAHVGAARRLISSLYLTKAHLDGAIAPLVNAIAADCLTYRIYGSTISGNTSSWSDNTIDDGVVLPYILQNAEAYSYHCAPPAILQIILSASQLCSGSSTTLETDGGAGRIVTAAALLHKARNFDVQTWVYNIKGLPPDDDLEARVSVASAHRAAACLFVLLSVPETGLLEIPLLEPKDLVQEILGHLSCIPDNHVHLKGTVWPTFVVGAETDDLSERAWCLERLVAVWTKNPWTYPWGYVHTAMEMLQEIWRLKDLAAQQGDDGINWLQRLKATENSCLIV
The following text describes a protein:
Function:
May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1.
Subcellular Localization:
Synapse. Note=Presynaptic region.
Sequence:
MSYSNGNINCDIMPTISEDGVDNGGPIDEPSDRDNIEQLMMNMLEDRDKLQEQLENYKVQLENAGLRTKEVEKERDMMKRQFEVHTQNLPQELQTMTRELCLLKEQLLEKDEEIVELKAERNNTRLLLEHLECLVSRHERSLRMTVMKRQAQNHAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVAMERVATLEEELSTKGDENSSLKARIATYAAEAEEAMASNAPINGSISSESANRLIEMQEALERMKTELANSLKQSTEITTRNAELEDQLTEDAREKHAAQESIVRLKNQICELDAQRTDQETRITTFESRFLTAQRESTCIRDLNDKLEHQLANKDAAVRLNEEKVHSLQERLELAEKQLAQSLKKAESLPSVEAELQQRMEALTAAEQKSVSAEERIQRLDRNIQELSAELERAVQRERMNEEHSQRLSSTVDKLLSESNDRLQLHLKERMQALDDKNRLTQQLDGTKKIYDQAERIKDRLQRDNESLRQEIEALRQQLYNARTAQFQSRMHAIPFTHAQNIVQQQPQASIAQQSAYQMYKQQPAQQYQTVGMRRPNKGRISALQDDPNKVQTLNEQEWDRLQQAHVLANVQQAFSSSPSLADVGQSTLPRPNTAVQHQQDDMMNSGMGMPSGMQGGMQGGMGGGQDAQMLASMLQDRLDAINTEIRLIQQEKHHAERVAEQLERSSREFYDDQGISTRSSPRASPQLDNMRQHKYNTLPANVSGDRRYDIYGNPQFVDDRMVRDLDYEPRRGYNQFDEMQYERDRMSPASSVASSTDGVLGGKKKRSNSSSGLKTLGRFFNKKKNSSSDLFKRNGDYSDGEQSGTEGNQKADYDRRKKKKHELLEEAMKARTPFALWNGPTVVAWLELWVGMPAWYVAACRANVKSGAIMSALSDQEIQKEIGISNPLHRLKLRLAIQEMVSLTSPSAPRTARLTLAFGDMNHEYIGNDWLPCLGLAQYRSAFMECLLDARMLEHLSKRDLRTHLRMVDTFHRTSLQYGIMCLKKVNYDKKVLADRRKACDNINTDLLVWSNERVQRWVEEIGLGVFSRNLVDSGIHGALIALDETFDASAFAYALQIGSQDVPNRQLLEKKFIGLVNDHRQQSDPHPRSGSSRKNDSIAKSYEFHLYT
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSALIIFGLLIALMLTGMPISISLGLTVLTFLFTMTQVPIDTVALKLFTGIEKFEIMAIPFFILAGNFLTHGGVAKRMINFATAMVGHWHGGLGLAGVIACALFAAVSGSSPATVVAIGSVILPAMVNQGFPKQFGAGVITTSGALGILIPPSIVMVMYAVATSGMVVTGPDGQPVSSASVGELFMAGVVPGLMLAGFLAFTTWNRARKFGYPRLEKASLRQRWTAFREAAWGLMLIVVVIGGIYAGIFTPTEAAAMSAVYAFFISVFVYKDLTLRDVPRVLLSSANMSAMLLYIITNAVLFSFLMAHEGIPQALGEWMVNAGLSWWMFLIIVNILLLAAGNFMEPSSIVLIMAPILFPVAVRLGIDPVHFGIMIVVNMEVGMCHPPVGLNLYVASGITKMGITELTVAVWPWLLTMLAFLVLVTYVPAISLALPNLLGM
The following text describes a protein:
Function:
Probable methyltransferase that uses S-adenosylmethionine as the methyl donor. Binds neither NAD nor NADP in vitro.
Sequence:
MHYFSEKPTTKSDVKIVEDILRGKKLKFKTDSGVFSYGKVDKGTKILVENVVVDKDDDILDLGCGYGVIGIALADEVKSTTMADINRRAIKLAKENIKLNNLDNYDIRVVHSDLYENVKDRKYNKIITNPPIRAGKEVLHRIIEEGKELLKDNGEIWVVIQTKQGAKSLAKYMKDVFGNVETVTIKGGYRVLKSKKL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEEKPSGPIPDMLATAEPSSSETDKEVLSPAVPAAAPSSSMSEEPGPEQAATPPVWERGGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPRRRPPPGKQIPCSSPGCCLSFPSVRDLAQHLRTHCPPTQSLEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRSLFKHLHVCAEHAQSPAPPPPPALDREPPAPERPPEVDPASAPGLPFPLLEPFTTPAPAPTGPFLPYLNPAPFGLSPPRLRPFLAAAPGPPASSAAVWKKSQGAGSSPRRPQGGSDAPSGACR
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRGPNRRPTGASASTSSKREPEEDLPSASEESDEDEEVSSSSVSESESGSDDEDVARERELERALADVPFGELQRARADGSLALRTASAAKAAAEKKARRASKKRPMEISTKMRPPKLREVIQVPKKVVRDPRFEPIYGSVDKEGFRKRYNFLFDEDFPAEKQRLQEMIKKSKDPNAIEEMKSRVTWIDKQLKSHPRKNVESEILREHIKKEREAAKAGKRPYYLKRSELRERKLINKYEELKEAGKLDAFMEKRRRKNASKDHRYMPYRRNGDSA
The following text describes a protein:
Function:
May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
Sequence:
MPARDETGMTQQLPATDDLEQIAARVDAAVAAVAGLEPAAQTVALELKQAIEAFHKLALTTMVRHLKHDPRGKELLLELVADPAVYAMLLMHGIVRADPITRARRVLDSARPYMQSHGGDAELIDVRDGVAYLRLHGSCNGCSLSAFTLRKHVEEVLLREVPEITRLEVVNDQPAPAMLRAEAQTHPDPAKGWVQGPAVTAVPPGQMISFTTDQTSVLIVNLENRLSAYRNACAHQGRPLDGGVLDPANGTLTCPWHGFCFDVTSGECLTAPQAQLEPFPLRVVDGMIWVRPL
The following text describes a protein:
Function:
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
Sequence:
MDALKPSHRAFIALGSNVGERVEMIEKACLEMDRAGIKVQRTSSLFETAPMYYLDQEPFMNGVCESIEVSLGRKKLIDKGPRSIDLDILLYDQQVFTHDRLNIPHKLMLERDFVLRPLSQLIPNEVPPFKGHKTTYLSHLASLPPPSPTPVATTYISPSFPPLRATDPSRRTHIMAILNLTPDSFSDGGKHLAEPEAITSTVRSFIQSGATIIDIGGESTRPGSTPVGVDEELRRIIPAIRHIRTSIPEAKNIAISVDTYRARVAAEALAAGADIINDVSAGLLDPEMLPTVAQSGKSIILMHMRGSPSTMTKLTSYANGVISDVGTELLARVAAAEATGIRRWRIILDPGLGFAKNQAEDLTILKDFAALRKTQGLEYFPWLMGPSRKRFIGRLTGVEKASERGWGTAATVTASVAGGADIMYKNLTEGTTDL
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTKSVVMLRGVVSTKLVCSRSGVKLIVCISTPPIKVSQPPRHCCLTGITQPAFDKSVDHLLLSCNANNHPDITRKPDHHHPEMFRGTPPNPYDEVVLKATDEAQTSENWSLFIQVCDKVLTDTSPTGPRDCIASIQKRLQHRNANVQLFCLTLTESLVKNTNENLHKEVSSRAFMKVLSGLVLDRYTHEKVQKRILQCLKSWVDDFHGKPHLGLVEETVEELKEKGHQYEEEPPPATHPPDELLKREEEELQRALAESEREAEWMNMAGVGNFPASTLDTQSNIGPAGHIPSSSQARFGNPPLASGHTAPDPTPHPAPVNRASSQPPAGNHHHQAPIDAMAQMSLQNSHPDSDNIPLGPATGSDLHPVRTKGRPAPKKVKALYDFGPNEEGELSFKEGDIIRVIDSVYKDWWKGELRGQIGIFPVNYIETIPDPSPEALTREAEAEAAVFAQACEIDRLLQMMNNLDAKRDNLADNDELSELYQRTLSMRPKIVRLIEKYSQKRAELLQINNKFMKAKTTYDTMIEQSLAVHHPGVAAETYTQPNQNHMSSNMYGSQGPYPQVTYSYDQASHPAHQPLSNQHYQRPTGPPASPNQPYPPRDIVPPEGLDTSRFYLASDGNWYAYSAEQLAAHASSTAALPNNPAVHTSHPPNSSQHAQPQSSPARNPTSAPQGDANHRPELNPAWPAYPPNSSPNSHNLPASLPLPGQ
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum lumen. Membrane; Single-pass membrane protein.
Sequence:
MATAIDEEETTATEGALVLLPLTYIVETGQRWEMSAQTAGYVIGLCLCDYGASFATKLALKTEKADAGFFSAVVRLEKLVQEEREVVAMVKQFIQEGRQVSADMQRYVQSFDISISGTDHIARQVYHPVRAYLLIKRLSQVPNNLSEAQALTGRRFELPTDEDLYMSALALVRLQHVYNLDMRSLAQQGQIVMVPLPQETNDEEPVREMTEVSTKDPTISLDPSDTFYIGDVASKENSFYQAMLWFNMTLEMIREKETSSLKVKHDDNGLKILDVLLKLADTVQKIQWNKAVSMAMSKLGNFCVDDDLFCPQWAGMGECDVNPKFMLHSCRLSCGVCEVGQNVKAQKVEANEDDLRLLSNVLRNVTSSLTKPNYVHEKLCRLGVLKNQAPHPTLTCRYIRPSPYFYLSPIKMEVLHETSPLVALYHDVITDKQTAFMKDMALDKLKRSPVLANDGSADGGNVLSTARVSETGWLFDSEHPAIVKLSRRVEHITGLNTNCPSAEAFQVVNYGLGGLYETHHDYLKLQEPTVLCYSQDNQTVKMTTGERIVTFLFYLSDVEAGGATVFPNLNLAVPAIKNSAVLFHDLKRSLALEENSLHAGCPVLMGSKWIANKWIRAHGNEFRWPCGLTPEE
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAAITTSKVEYLPIIMAGGKGSQLIQMTSDIPKSLLPIANKPMIYYPIKWLETSGFEEVKIVTTKLILTKLQDGLKDYFLEGKGIKLDYVVLPDHDESEDLGTVDAIKFMLQDIKMDVIVVSCDFICDENFCLRRLDQVHKSKNASISMLLSSPPNLTDVPVPVPESNRSVDRDFVGFDKTNRIVFLSPESYLEDKIELRMTKLRAVPHIELRSNLVDCHLYIISRPFLNLVDFVKSFSLSSDFIPWLAGQSVEASSSVLKFFDQSKSPESEFEEEINDLDRLIAEQNYKYLTSNSNNLNNNNNNNNNNSNNKSSANINVYALIHDSGFGSNNNNKENKNIKENSNANKDVVVGDSFCMRANTLATYCKANQIRGTSLIGQGTKVGNETRQGTETKQGIDSKPANETKPGQRSHVRNSTMSNSLICSDAKIADEVVMKNSFVGHSQSVPQGTYTSEEICKEEHDEEDIL
The following text describes a protein:
Function:
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
Subcellular Localization:
Secreted.
Sequence:
MLKIWGLVLFCGLLTQSSAQLEAIPVDPAIPLRPAQSLTPPDPLSGLLGGLTKGLLNSNLLGILENLPLLDALKIGEGSSAGLIGGLLPKIVSLVPGLQDIISINITNPVLLELGLEQSPDGHRLFVTLPLGMVLELKTFLTGEILKLDVKLNIIVELIAVRDKDGKIHLVIGDCKNDPGSLKVTLLEGVLPSVVQGLLDTVTGTVIKVLPNLIQKEICPLVNDVLGNLDVTLVHDVAELLIHGIELHLKI
The following text describes a protein:
Function:
Component of the FER-regulated Rho GTPase signaling complex. Acts as a chaperone and coreceptor for FER. Required for localization of FER to the plasma membrane.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MELLSRALFFFLLLSVLSSFSSSSFISDGVFESQSLVLGRNLLQTKKTCPVNFEFMNYTIITSKCKGPKYPPKECCGAFKDFACPYTDQLNDLSSDCATTMFSYINLYGKYPPGLFANQCKEGKEGLECPAGSQLPPETSAEVNAATTSSSRLWLTVSAALLVFVKLF
The following text describes a protein:
Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
Subcellular Localization:
Nucleus.
Sequence:
MSAPAYYELYRRSTIGVTLMDALDTLISDEKIQPQLANRILINFDRIIAENLKNENIVGKSKLIFKGDLDTYRFCDDVWTFIIKNVIIKLNDVSSKDSGGGDKDKDSGDLELNVDKFKIVACNSRKAGEM
The following text describes a protein:
Function:
Transcriptional repressor. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Subcellular Localization:
Nucleus speckle. Nucleus. Chromosome. Note=Speckled nuclear localization requires both CR1 and CR2 regions. Localizes to sites of DNA damage.
Domain:
Both CR1 and CR2 regions are required for speckled nuclear localization.
Sequence:
MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLKRKDLANLEVPHELPTKQDGSGVKGYEEKLNGNLRPHGDNNRTAGRPGKENINDEPVDMSARRSEPDRGRLTPSPDIIVLSDNEASSPRSSSRMEERLKAANLEMFKGKGMEERQQLIKQLRDELRLEEARLVLLKKLRQSQLQKENVVQKTPVVQNAASIVQPSPAHVGQQGLSKLPSRPGAQGIEPQNMRTLQGHSVIRSATNTTLPHMLMSQRVIAPNPAQLQGQRGPPKPGIVRTTTPNMNPAISYQPQSSSSVPCQRTTSSAIYMNLASHIQPGTVNRVSSPLPSPSAMSDAANSQAAAKLALRKQLEKTLLEIPPPKPPAPLLHFLPSAANSEFIYMVGLEEVVQSVIDSQGKNCASLLRVEPFVCAQCRTDFTPHWKQEKNGKILCEQCMTSNQKKALKAEHTNRLKNAFVKALQQEQEIEQRLQQQAALSPTTAPAVSSVSKQETIMRHHTLRQAPQPQSSLQRGIPTSARSMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHKAPSLADRQREYLLDMIPPRSISQSISGQK
The following text describes a protein:
Function:
Has a role in regulating DNA replication complexes. Acts as a regulator of post DNA replication initiation. Associates with chromatin during G1 and S phases of mitosis. Required for the transcriptional repression of the outer repeats of the centromeric region. Acts as a polymerase alpha replication accessory factor and is important for S-phase DNA damage survival. Plays a role in lagging-strand synthesis and Ozaki fragment processing, in addition to DNA repair.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAGNRLVPRYAHTDGLTRLAYTRDGKFLLTVGSNQVIRKFQVGSDEEPDSIDNHQDPITGIAVAENYFCTCSEDATVCVYPIDSPTEHTLLARTTLPIRDVAYSVDGNWIAIASDETAVKVVSSTDSSQIFSLRPAKASNKHVTYSPNGNFLAVSSCNGILYFYDTQTRELIKFLTNTIASLEAESEICSKAAWHPKNGTFAVASTDHFVSVISPDDWLPLYKLLPKENHSGVTDISWSSNGMYIAASFKKGGILIWDTQSHEVVVELPYSTVVALAWQPFENVLSFTTNQGILYSCPDVIPKSILKEENDPTKPLTSSKSKNRTSKELDDLFGSDDEQSQNVNDLDGNSANEENEFINHDGLDSSLDLDGDSYMVDENDLNLAKKRKQKALIDRTTTIENGSSKRRLLQASIHKPVHTGSTPWQGNRRYLCLNLVGFIWTVQQDAEHNTITVEFHDETTHRKYHFVDDQKFEMACLDHEGALYASPATESSPGVIYYKAHVDWSRKSEWAMALPMENESPVTISLSSSVVLVCTSAGYVRVFSRQGFPISIHRSKHLPFVACSSFQDTIITIANDGLSSDGNSRLVYSIEDISRDEMLQTGDGVALPPQGTLESVFFSDVGDPYIYDSTGVLLVLMHWRIPGQAKWIPVLDTNELERRKSRQESYWPVTVADNQFHCILLKGASRYPYFPRPMFTEFDFRIPCNTNNPDASTSVPVLEELQLRNKLFLTLLEDSIGDGDVTEDEKISIARLEANIDKALLQLIQKACLEERIERVYELTKTLRRTTSIAAAQKIALHHSLTNVAEKIGNLLSNV
The following text describes a protein:
Function:
Part of the HipHop-HOAP complex that recruits the MTV complex to form the terminin telomere-capping complex, which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, telomere. Note=Colocalizes with cav/HOAP at polytene and mitotic chromosome telomeres. Telomere localization is enhanced by the activity of tefu/ATM and the MRN complex. Telomere localization is not dependent on the MTV complex components moi/modigliani, tea or ver/verrocchio.
Sequence:
MASIDEGSRVERRFCAVGNHTLRKPYRQLNNKYLVRFACLLNSEIRAGNLICCKCYTDLVRLYRKKNDNAKRHKMARETAASITDVSGSQSSSHQSAPSLHVSGQSSEFGASYSEGGIVTPDEELCSHRSLSQDSDNVPTTSAAAIQKRQLARANLMVKPSQRLSLAQTTPDCDDYDPNSNLSLNAVNGTRLPHIQPIPKRRPTVLDKQSMDIYLMGTTGG
The following text describes a protein:
Function:
Possesses in vitro histone acetyltransferase activity with histones H3 and H4.
Subcellular Localization:
Peroxisome.
Sequence:
MTNTAATTEAKMATEPPKIVWNEGKRRFETEDHEAFIEYKMRNNGKVMDLVHTYVPSFKRGLGLASHLCVAAFEHASSHSISIIPSCSYVSDTFLPRNPSWKPLIHSEVFKSSI
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGSCLSSPSSSSTLPRTRTVDYKVNYIARPTRTKQQVRAKPSTKLCLICMDEKSPSDIFRGTTSCTHSYCTECTVRYVTTKVEENAARARIKCPDMNCTQLIEPYTCRDLIPKDLFVRWDKALCELLIMSSEKVYCPFEKCSACDGGSGCKETKKKKTRNSDKEDALLIDLAKKKKWRRSGALNANSTLRKPLVVCI
The following text describes a protein:
Function:
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
Subcellular Localization:
Secreted.
Sequence:
MRLLTLLCLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGHESTDTERAPGNDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPACDHHCHNHLGGFYCSCRVGYILHRNKRTCSALCSGQVFAQRSGELSSPEYPQPYPKLSSCTYSIRLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDSEEHGPFCGKTLPRRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHLSPVQAKYILKDSFSIFCEPGYELLQGHLPLKSFAAVCQKDGSWDQPMPSCSIVDCGPPDDLPSGRVEYITGPEVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGERSPPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGSTAAGALLYDNWVLTAAHAIYEQKHDASSLDIRLGALKRLSPHYTQAWAEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGLLARNLMYVDIPIVDHQKCTAAYEKPPYSGGSVTANMLCAGLESGGKDSCRGDSGGALVFLDNETQRWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIKNIISNF
The following text describes a protein:
Function:
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Sequence:
MEKHVLDRDDAVRGTNEDALTSKHSAVTAGYLQDPYIKAFLKRGSKRAPIINRGTYARTAGLDILIKQFLTATIPLQDATGSEIPGSGTRPMDKQIISLGAGSDTRFFNFKADGINPRRYIEIDYPQITAKKAHAIVRDKNTRLVIGEDSYKVLGGGVELVADSYWLIPGDLRDFTCILPKLVSMGLDTTLPTLILSECVLIYLDPIVSHSILTTMASSFTTAVVATYEQILPNDAFGITMLNNLKTRNITLPGIHDCQTLEHQISRYIECGWTTSRAINLNTVWDKCISDSEKLRVSKLEIFDEIEEWQLLSMHYCISWAVKLGHANDDMAQTYVDKLWFKYEH
The following text describes a protein:
Function:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSSGRGRICCPSHPDAPLVDDCHAGDQICSECGLVVGDRVVDVGSEWRTFSNEAGNADPSRVGGAENTLLNGTNLTTMIGPSTSGGGTSFNETGGAVYKNRQTMSSSDRTLVNAFKEISNMADRINLPRTIVDRANLLFKSVHDGKNLKGHSTDASASACLYIACRQEGVPRTFKEICAVSKIGKKEIGRCFKLILKALETSVEIIKTSDFMPRFCSNLGLPAIVQRNASHIGGKAVELDVVPGRSPISVAAAAIYMASHASENKLTKKEIGDIAGVADVTIRQSYELMYPRAAELFPSDFKLIISQLPQR
The following text describes a protein:
Function:
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDITDRILQNRIVSKVIFFVLRSVTLSLVSVTRFSLFLLSFATITVPKWAYKIVTYSLTIQFNFKSLLFLFFVSICVVILVVRYRYLNKYARLPHEAPIKEAKLGPDTNIRPSEPRIGFQNYLDEFLSAISIFGYLEKPVFVELARHIRTQRVAEGNTIYLGEQSSFILVVDGCFQVFTAPEKDSAEVVEEAGQPEYRLLTEVSNGAPLSSFFTVLELFTELIPEATSKENPFKSTTSSLRPGSSTTTEAGANNASKPHMPQPKKARIIAKAKIDTTIAVIPANAFHHLVHKFPNSSAQIVQVILTRFQRVTFSTGYEYLGLSDAIFSIEKNFNSLTAYELPNYIRSDIIDDFKKEAMSEHLSQASNESFIVLRSKGAQSRLSNQYFSKAFDKEHGNFVSDIDRSTANAGDLLSSTNPHSTLLSTSVGPLRKFPLNRSYSREVGDYDISASFRDGLLQCIFKSLGVFNYELKEDNDDLCTENDSSEGDSDSLKKVDFLGQIAMMSATDREEVKSSIVVSTKKSTILEFAKEIEIIFYKKGTTIVRQGDHADGLYYIIDGFLDATCPSKLTFSTSYDTDLGMHSFMIKPGGIVNYQACVSNYRSFINVTARSDVLVGFLPRSCLERIIDQEPLISLTIAKRLISLVPSLLLKLDFAVGWIHLNPDQVVYEKNDPSDCVYVVLNGRLRSIEDERGSARTQVDYFNEYGKGDSVGELEMLLNNRRSSTLFAIRDSELAKIPETLFNALSLSHPAVGLQLSKIIANRMNLLLNNKSMDGMQHQPHEKHSIRTLAIVPSSSTGLLILFSQKLTSVLSVMGKSVKVLRQSSVLEHLGKHAFSRMGRFKLSSYLSDLEDKYDILIYVADSGVGSAWLQTCIRQADCIYILAEADQNPNIGEYEQHLIAMKSTARKELVLLHPERFCPSGLTRLWLKERPWVYAHHHVQLRIGLDNEISQNNEAKVFLNIIRAKVQNLHYGFRKYIDWKHLHPVYQANRAQDSDFARLARRICGKAIALVLGGGGARGISQIGILYALEEAGIPFDIIGGTSIGAFNGGLYAWEADLVPMFGRAKKFCGRMANLWRFVLDVTYPQAAYTTGHEFNRGIWKTFGEIHIEDFWLPFYANTTNITHSRMDIHSSGYAWRYIRASMSLAGLVPPMLSDSGDMLLDGGYMDNLTVSHMQSLGASSIFAIDVGSEDSREPMHYGDTVSGVWALISRWIPFIPKTSFPSLAEIQSRLTYVTSVATGEKVKSMPGCFYMRPPVKDFPTLEFGSFEKIYNVGYNYGKEYVEKLKTSHKLDDILSPRDTSKRHPKFLSSRRNSL
The following text describes a protein:
Function:
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMRVSTYFPKLGLIQLYDGEHVSLIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEFDQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNVEIDKGATRTNWIKRPLSDIQLQYAAGDVWYLLPLYHILEKELAKTPWEQAVRDDCELVLAKTHKLQERDSEKAYLDIPNAWKLNPLELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVRGKEILQLLSQARRISSNDYPKSIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKRTLEELIKWVWKYDCSQDKRPELLIGWRKPIGEKLVDALK
The following text describes a protein:
Function:
Polymerase-regulating component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase PAP1. This inhibits the extension of an oligo(A) primer by limiting access of the RNA substrate to the C-terminal RNA binding domain of PAP1. Seems to tether PAP1 to the cleavage factor I.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
Circular dichroism measurements suggest that the protein is largely unstructured in the absence of interaction with PAP1.
Sequence:
MSSSEDEDDKFLYGSDSELALPSSKRSRDDEADAGASSNPDIVKRQKFDSPVEETPATARDDRSDEDIYSDSSDDDSDSDLEVIISLGPDPTRLDAKLLDSYSTAATSSSKDVISVATDVSNTITKTSDERLITEGEANQGVTATTVKATESDGNVPKAMTGSIDLDKEGIFDSVGITTIDPEVLKEKPWRQPGANLSDYFNYGFNEFTWMEYLHRQEKLQQDYNPRRILMGLLSLQQQGKLNSANDTDSNLGNIIDNNNNVNNANMSNLNSNMGNSMSGTPNPPAPPMHPSFPPLPMFGSFPPFPMPGMMPPMNQQPNQNQNQNSK
The following text describes a protein:
Function:
This bird and reptile-specific postsynaptic neurotoxin inhibits the chick muscle alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND) nicotinic acetylcholine receptor (nAChR) 100-fold more compared with the mouse receptor. In vivo, produces rapid flaccid paralysis, dyspnea and increased respiratory rate in geckos. At sublethal doses geckos were immobilized for up to three days and then recovered. Chicks injected with lethal doses showed rapid onset of inactivity, dyspnea and neck droop, and no extended paralysis with survival was seen.
Miscellaneous:
MISCELLANEOUS: IC(50) is 11.2 nM for indirectly stimulated, nerve-evoked twitch responses of the chick biventer cervicis muscle acetylcholine receptor channel; MISCELLANEOUS: Negative results: is not toxic to mice at doses up to 25 ug/g (i.p.). Does not inhibit mouse alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-7/CHRNA7 nicotinic acetylcholine receptors.
Subcellular Localization:
Secreted.
Sequence:
MKTLLLAVAVVAFVCLGSADQLGLGRQQIDWGKGQAKGPPYTLCFECNRETCSNCFKDNRCPPYHRTCYTLYRPDGNGEMKWAVKGCAKTCPTAQPGESVQCCNTPKCNDY