lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A nucleoid-associated protein (NAP) that probably plays a role in chromosome compactation. Binds DNA non-specifically, with greater affinity for supercoiled than linear DNA, binds well to nicked DNA, gapped and cruciform DNA. Has a preference for A:T rich DNA. Required for activation of the mtbB operon. Binds the mtbB promoter in the presence of iron, binding is seen with as little as 25 uM Fe(2+) and increases with increasing Fe(2+). RNase E and HupB jointly contribute to cellular adaptation to changing growth conditions and survival during antibiotic treatment and in the host. Plays a role in stress survival. Stimulates supercoiling relaxation by topoisomerase 1 (Top1, topA) (By similarity); Binds Fe(3+) but not Fe(2+). Has ferroxidase activity, converts Fe(2+) into Fe(3+) and in the presence of H(2)O(2) prevents the generation of hydroxyl radicals (the Fenton reaction). Protects DNA from damage in the presence of FeSO(4) and H(2)O(2). May function in iron storage. Involved in iron uptake by bacteria (either Fe(3+) or extracellular carboxymycobactin); antibodies against HupB block uptake of both. Following uptake iron is mostly found in the iron siderophores carboxymycobactin (CMb, extracellular) or mycobactin (Mb, lipophilic). Facilitates transfer of iron from CMb to Mb when liposomes plus a cell wall lysate are incubated with CMb. Binds iron, ferri-CMb and ferri-Mb; has 10-fold higher affinity for ferri-Mb. Suggested to transfer iron from CBm to Mb at the cell membrane; Required for biofilm formation; trimethylation by recombinant human SUV39H1 (a histone methyltransferase) inhibits biofilm formation. Induces lymphoproliferation, particularly in health tuberculin reactors, and is immunogenic. Maybe involved in pathogenesis of inflammatory bowel disease (IBD) in patients with ulcerative colitis and Crohn disease (CD). Bound by anti-neutrophil cytoplasmic antibodies (pANCA), which are a hallmark of IBD. The binding is due to pANCA directed against H1-3 cross-reacting with DBH epitopes. In CD, target of a strong IgA response; May play a role in cell wall assembly (Probable). In vitro at low levels enhances formation of TMM and TDM by antigen 85 proteins (fbpA, fbpB, fbpC), at higher levels inhibits TMM and TDM formation (Probable).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm, nucleoid. Secreted, cell wall. Note=Found along the cell length in a bead-like pattern (probably associated with DNA). Only seen in the cell wall when grown under low iron conditions.
Domain:
The highly basic C-terminus confers greater specificity in DNA binding to all tested dsDNA. Residues 1-102 stimulate Top1 and physically interact with it (By similarity).
Sequence:
MGMNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFRPGAQFKAVVSGAQRLPAEGPAVKRGVGASAAKKVAKKAPAKKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKATKSPAKKVTKAVKKTAVKASVRKAATKAPAKKAAAKRPATKAPAKKATARRGRK
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP; May be involved in the biosynthesis of molybdopterin.
Sequence:
MGQNIYLSNYEIEEALKFYFSKISIERQNEFIDTEYSSNRITASPIYSKISSPFYNSSAMDGIAVNSEKTLGANEKNHIALEEEKDYIVVDTGDPIPREYNAVIMVEDLIKVDDKRVKIYKSIAPYENIRPLGEDIVEKSLIVPSYHKIRPVDISAMIAGGVNEVEVYKKPLVGIIPTGTELVEPGNNLKVGDIIDFNSRTFAAQVFEYGGIAKRYEIVKDNYEKIKDTIKKAVKECDIVLVNAGSSAGREDYTAKIIEDLGKVYIHGVAIKPGKPVILGKIDNKPVIGIPGYPVSAYVIMENFVRPMVKKFAGEKPYKYKKIKATLSKRVMSSLKYVEFIRIKLGKVGEKIVATPLNRGAGATMSLVRADGILEVPQNVEGIEKGTEVDVKLLKDEEEINNTIVCIGSHDPIIDVIADLIHVKQGGYYLSSAHVGSMGGIMALKNGETHIAPIHLLDMESGEYNVSYIKKYIGNRPMALIKCVKRIQGIMVPKGNPNNITSIRDIRDKKLKFVNRQRGAGTRLLLDYNLKKLNINPREIQGYEREEYTHLQVAAAISNGDAHCGLGVYSAANMMGLDFISVCNEEYDIVIFEEFLSMPSIKEFISIIKSDKFKERLDELGGYDYSEAGNIVFI
The following text describes a protein:
Function:
Catalyzes the reduction of acetoacetyl-CoA to (R)-3-hydroxybutyryl-CoA. When expressed in E.coli with Synechocystis PhaA, PhaC and PhaE confers the ability to synthesize up to 12% (w/w) poly(3-hydroxybutyrate) (PHB) depending on the carbon source.
Miscellaneous:
MISCELLANEOUS: Nitrogen-free medium induces chlorosis in Synechocystis, leading to the degradation of the photosynthetic apparatus and concomitant accumulation of cytoplasmic polyhydroxyalkanoic acid (PHA) granules which in this cyanobacterium are composed of PHB.
Sequence:
MLSLGLEDKVIVVTGGNRGIGAAIVKLLQEMGAKVAFTDLATDGGNTEALGVVANVTDLESMTAAAAEITDKLGPVYGVVANAGITKDNFFPKLTPADWDAVLNVNLKGVAYSIKPFIEGMYERKAGSIVAISSISGERGNVGQTNYSATKAGVIGMMKSLAREGARYGVRANAVAPGFIDTEMTLAIREDIREKITKEIPFRRFGKPEEIAWAVAFLLSPVASSYVTGEVLRVNGAHHT
The following text describes a protein:
Function:
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRLLSVTFWLLLSLRTVLCVMEMQWCTISDPEQQKCKDMSKAFQGAGIQPSLLCVQGTSTDHCVQLIKDQKADAITLDGGAIYQAGKEYGLKPVVGEVYDQDIGTSYYAVAVVRRNSNVTINTLKGVKSCHTGINRTVGWNVPVGYLVETGHLSVMGCDVLKAVGDYFGGSCVPGAGETSHSESLCRLCRGDSSGHNVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKTLPSWGKALMSQDFQLLCRDGSRADITEWRRCHLAKVPAHAVVVRDDMDGGLIFRLLNEGQLLFSHEDSSFQMFSSKAYGQKNLLFKDSTLELVPIATQNYESWLGQEYLHAMKGLLCDPNRLPHYLRWCVLSVPEIQKCGDMAVAFSRQSLKPEIQCVSAESPEHCMQQIQAGHIDAVTLRGEDIYRAGKAYGLVPAAGELYAEEDRSNSYFVVAVVRRDSSYSFTLDELRSKRSCHPGLGSPAGWEVPIGSLIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEKGRNKCVGSSQERYYGYSGAFRCLVENAGDVAFLKHTTVFENTNGHNPEPWASHLRWQDYELLCPNGARAEVDQFQACNLAQMPSHAVMVHPDTNIFTVYGLLDKAQDLFGDDHNKNGFQMFDSSKYHSQDLLFKDATVRAVPVREKTTYLDWLGPDYVVALEGMLSQQCSGAGAAVHRVPPPALLLLALAAGLLPRVL
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system.
Sequence:
MVNQFDVVLIDLNPTVGAEINKTRPCVVISPDDINQHLRTVIIAPLTSTPRGWPFRPVVQGSKVKSEVAIDQMRAVDKNRIIKKLGQLTAIESNLVASVVKEFFE
The following text describes a protein:
Function:
Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MVRSLVRRLLGRSQNNGTAAPALELPPEDSRARARAMVMGLQDEICAGLESLDGEGTFVEESWERPEGGGGRSRVMREGLVFEQGGVNFSEVQGQELPPSILKQRPEAKGHPWFATGTSMVLHPHNPYIPTVHLNYRYFEAGPVWWFGGGADLTPYYPFLEDARHFHRTHQAACDSVHPDLHKVFKPWCDEYFFLKHRGETRGVGGIFYDYQDSSGVLYKGQDPSGPAAGVSAQLGARPLGWEQLFALGQANGRAFLPSYAPIVEKRHPMAYGDRERQFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLVRWEYGYKAEAGSREALLTELFTKPQDWLGDASLEDRCRPHGAIN
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MDEKLLDSSEETQVTIKSSRPNQQSINSNELIIIEQPSEQQNYGTSEELQNIQWMQPPQVCQPDAPPGLEYLTQIDQLLIHQVIEIFEAVTGFQTRKRFFVKNSMGQQVLFASERNDCLTMQCCGSIRPFEINLTDNMKRDIIHLSRPMRLGCRCFPCCLQELEVQAPPGETIGYVRQIQTFVKREFNILNTFRDPVLKIRGPCWLCSCLTDIDFDILTSDGETVIGKITKQWPGLWRETFTLADNFGIRFPVDLDVKIKATLLGAVFLMDFMYFEGNNRRRRRY
The following text describes a protein:
Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
Subcellular Localization:
Secreted.
Sequence:
MPVLSNPTAVVLLLIAHCGSWTGAIHLGSFKVCPSCRDPLGAGRPPRDHNAAGSTTVLAQGEPCGVYTLSCAKGLRCVPPPREQSPLQALLQGRGVCAKHSRTIPTERPHPTGPHPSHSGDIEKAPCRKLLNSVLRGLELTIFQSDRDIYIPNCDTRGFYRKKQCRSSKGMQRGHCWCVDELGVPVPSRANEDGTLPCDGE
The following text describes a protein:
Function:
Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MKITSRHIEKDGSGRITIVPEEDEDMYHLYNLIEQGDRVRAAAVRRVQSESSTGSIESHRVRLNLTIEVTKTTFDATGSSAPPDPSAATASTPSTTAEEEVSRSAAVGGSGGDGATLQVAGRVVEENVYVKMGAYHTLDLEVNRALTITKESWDAVHLERLGESTDVSQRAEVGAVVLGDGTAAVCLLTGHMTVVRQRIDVPIPRKRKGLPATAADKATARFYVQVYNAVVKLLQLPALRLIILASPGFTRDSVYDFLFEEATRRGDKILIGSEARRKFLKIHCSSPHVHSLMEVLRSPEVNAQLKDTKFAREGQLLERFMKQLASDELRAWYGEQHVLLAASRGAIGVLLISDGLFRAADPARRKKFVELVEDVRAQGGEVAIFSSMHESGRQLNALTGIAAILTYPLDIEVVEEEEAEEARSKQGEAA
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in D-mannitol transport.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site; The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain; The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.
Sequence:
MISSDAKVKIQNFGRFLSNMVMPNIGAFIAWGFITALFIPTGWVPNETLASLVGPMITYLLPLLIGYTGGKLAGGERGAVVGAITTMGVIVGTDIPMFMGAMIVGPMGGWAIKAFDKKIDGKVRSGFEMLVNNFSAGIIGMLCAIIAFFLIGPFVKVLSGALAAGVNFLVTAHLLPLTSIFVEPAKILFLNNAINHGIFSPLGIQQASETGQSIFFLIEANPGPGLGILLAYMVFGKGTARQTAGGATIIHFFGGIHEIYFPYILMNPRLILAAIAGGMTGVFTLTVFNAGLVSPASPGSIFAVLLMTNKGSILGVVCSIFAAAAVSFTVAALLMKAQTSTEQDGDKDALVKATSIMQEMKAGSKGQAAPTATQSKKIDMANVQSIIVACDAGMGSSAMGASMLRKKIQEVGLPVTVTNMAINSLPAHVDMVITHQDLTDRARQHAPNAEHISLNNFLDSALYNQLVTQLLAAKRQAANDSQLIKPSILAANDDRYEVQQPSVFQLQKENIHLGLNAKNKEEAIRFAGNKLVELGYVHPEYVDAMFEREKLVSTYLGESIAVPHGTVDAKDRVIKTGIVICQYPQGVAFSEDSGDVAKLVIGIAAKNDEHIQVITTITNALDDPNAIDKLTSTKDVSDVLSILATSQAA
The following text describes a protein:
Function:
Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSAAPSPTAQSLAVVLVSPKTPGNIGAAARAMLNMGASDLRIVAPRCDYLDSQAVAMAVHAGDLLRSAKIYPTLREALADRDLSVGTSARIRADLPAPRHPAQVRGLVREAAAPALVFGPEETGLINSDLEQCQVTVRIPTGDYASLNLAQAVLLVCYEFLQGQDDVPEHSRQTATREDMEAMYGHLQDTMHLIGYTDAVRGRHTMRLWRAMLDRALMSSAESRMFRGLLRQVKWKVEQGSGKASTEIRIESEE
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
EDFDGVVNERSCTDIFFLALFLAFLGGLQFAIDFQLCWKEVVYLCLIALGLSLVLTVLFRFLAGAMIWLLLVALVLGSFGGTGYLWWAWYGMRGTSGETSMLAYAITLSIVSVFKFTLSFYFSPYPPLWTLLALCALCAGWAYAALWIESAGQPTRAPVGTVIFQKDTYLQVVRWYNILAALWLSQLCLAFQNLIIAGAVAEWFFTRDKSRLSCPVAKSTGYAVRYHLGSLAFGSLLIALMKLVRMLFNYLERKLRNSTTTCFGLVTCLTCFCKCCLYCFEKFLQGLCSNAYIEIGIYGENFCWSAGRAFKMLSNNALRVMAINSVGDFILFLGKAGVVTAVVFVGIELIKDKPGVVYIWTPILVAAIFAYLIAHCFISVFEMCIDTVFICFCEDCEINNGQDQPYFMSRGLMVNTDD
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MNPRIHMAIFIAFLAAHSVSSNINSASSVAKQQQVSGLNLKALDDLYIDDEGDDDIQLADEASGLGPLKPALGVEDEEEEEEEEEDEEEVDEYDDNPAPVEAAKKAKDAGTTATATTNSGGGSSNNNMTAGIISSSDYKDDVVAPPKVSPVAASPTMGKPPAPAVEDDEDDENFDGSGGSGAGTGSNVDDENEDEDDYDDTVTDEEGGGIDLGSVITEPAPKTTMKPEKKPEVVVVAPPTAPSSPTKAPKETTQAPSSPPPLSGGRDENQVPAEPMTTPVPGPVDPSQGSGGSMDGNRGHNDVQILDHKPDERQASFFAQPGILAAVIGGAVVGLLCAILLVMFIVYRMRKKDEGSYVLDEPKRNSPNSNPYNKNSREFYA
The following text describes a protein:
Function:
Transcription factor that regulates the gene cluster that mediates the biosynthesis of 5-hydroxy-2-hydroxymethyl-1,4-pyrone, also know as kojic acid, a by-product in the fermentation process of malting rice that acts as a chelation agent. Negatively regulates the expression of the kojic acid-related protein kap1. Improves the antioxidant capacity via the accumulation of kojic acid that is also a strong oxidant.
Subcellular Localization:
Nucleus.
Sequence:
MSLNTDDSGRIRTRQRAKRACETCKLRKRKCDGHEPCTYCLRYEYQCTFKPHPRRKPAASKSSARPSEEEDSPKFLDRVDANQEHMEANSGTAFPHLLGMRLNPQGAPKVYGFSWNLGPRDEPLEPFTNLTDLISREEMEDLASHYLKKIHPVYAVLDPDTLRQKIVARWHDPATAASYDPILCGVAALGSLYSGHQEHPKEGALVQSAKEMLETTRISKTTLLHHATAWILRTIYLRSTNCPHASWMASCSTMHIIEAIGAHQDPELVSLVYSDTADVSVNDESQRRLFWVATVLNSWISYEYGRSRVILRGVSCKPPLPRTGDFTTDLISMYQISERLDPDQNNKLSDLEDALSRVERLTLSHDALILSQSNLALTIYRRLRVASSNISNDILTRIIRLGNDGLEAAVRLAEDRSPWWHVANIPFQFLCILLAIDTRESLSYVGPALRSFRAITRHYSTPTLHTALETIESLVRLSQNKKERDLTLLRDSMQQEDPGLTEQGSTTSQAFNDASWLGATGDLTLPDNFDWDWNVFLDTQVPFFDEGEAGGQRYR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.
Subcellular Localization:
Golgi apparatus membrane; Lipid-anchor.
Sequence:
MITTTRDRQDHPLTRQQNNPAAGAELLAAGWARGAAMGSVLSSDSGKSAPASATPRALERRRDPELPVTSFDCSVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYQNCTECDTAVCLSEMRAHIRTCQKYIDKYGPLQELGETATRCVCPFCQRELDEDSLLDHCITHHRSERRPVFCPICRLIPNENPNSFSGSLIRHLQVNHTLFYDDFLDFNIIEEALIRRVLDRSLLEYVNRSNTT
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MYRQEATTVTILAQAPPNWPAPAFDISGFTSAFRPSRRAQRSNTTMGSIDTNSTDAWHTFAIPRLGIPAMRITDGPNGARGTRYFNGVPSACLPCGTALGATFDTDLLFKLGRLLAAECKAKGAHVLLGPTINIQRGPLGGRGFESFSEDPVLSGNSAASYCAGVKDLGIVPTLKHLVCNDQEHERIAVSAMVTERALREIYLMPFQLAIKNARPGALMTSYNKVNGLHASEDPGLLNHIIRKEWGFEGLIMSDWFGTYSVASAVNAGLDLEMPGPTRFRGPALMHALTSNKVSEKTLDDRVRKVLELVQLTSRAGIPEYAPAQKLDRVEDRVLLRQAAADSIVLLKNANEVLPLDPRKKTLVIGPNADIAAYCGGGSASLLAYYTVTPRQGIAEKCEEVVFSQGCYGHKELPLLGDHLKTETGERGYTFRVYTEPATYEDRQPVDVLHMTNSCAFLMDYSHPKISGDTYYATLEGRFEPTESGVYELGLTVAGTGLLYIDGELVIDNKTKQRHGTSFFGIGTVEERGERYLEAGRQHHVFVEYSTAPTSNLKHHGVVSFGPGGVRLGGCRKLDAETAIKQAVQLAAETEQVVVCVGMNGNWESEGFDRPHMDLPPGTDNLVRAVIEAQPNAVIVVQSGTPVTMPWADQAKALVQAWYGGSEGGNGIADVLFGDVNPSAKLPLTFPRDIAHNPSYLSYRSERGRVLYSEDVYVGYRYYDKVKQAPLFHFGHGLSYTTFKLSGLNVQETDPQASDISAEVVQIYVRPPTTASVGRPVRELKGYEKTMLHPGETKEISVTVPMGVATSFWDEGRSAWLSEKGTYAIEVVGTGERNMLSAPLCVQVSRYWNGL
The following text describes a protein:
Function:
Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSTSFACTTCTVAFNNAESQKIHWKSDWHHYNLKRKVASLPPLSAEVFAGKILSIQKQNEEVQKKAEFYQNCEVCNKKFYSEGAYSSHMASKKHRDNLSKFQRNSRIKKLQSEDASSIASSTLSMGEPVVDSEIEEEEDLASQLTSRAISLSNLSLHGRESEPSKTELATSIPQSNEASKSHLFTQEPTPEEIEAELARRSSQRLSPRDCLFCAASFSSFDTCKKHMKASHSLYIPEREYLVDEPSLFDYLAEKISIGFTCLTCNREFKSLEAVRAHMQQKGHTSIAYDTEDEQLELSDFYDFTTSYPDYAVKQDETVVEEDGSSGEGDWEDVSDDSDNSSLDSLEMGRVPIADEYELHLPSGNRVGHRSLSRYFRQNLHSSSTAVGDGASIHQNVARRAMSGNARAYRQAVETSIAGVRDGRKNYSASHIKSFQDQRRREEFANKMGIKNNTKKHFRDALLQ
The following text describes a protein:
Function:
Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid. Also recruits host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription. Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1.
Subcellular Localization:
Virion. Host cytoplasm.
Domain:
Comprizes a N-terminal arm involved in oligomerization, a NP core region involved in RNA binding, a disordered region follwoed by a C-terminal tail involved in protein-protein interactions. During oligomerization, NP N-terminal arm binds to a neighbor NP thereby displacing VP35 bound to monomeric NP.
Sequence:
MDSRPQKIWMAPSLTESDMDYHKILTAGLSVQQGIVRQRVIPVYQVNNLEEICQLIIQAFEAGVDFQESADSFLLMLCLHHAYQGDYKLFLESGAVKYLEGHGFRFEVKKRDGVKRLEELLPAVSSGKNIKRTLAAMPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHPLARTAKVKNEVNSFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLFPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAESRELDHLGLDDQEKKILMNFHQKKNEISFQQTNAMVTLRKERLAKLTEAITAASLPKTSGHYDDDDDIPFPGPINDDDNPGHQDDDPTDSQDTTIPDVVVDPDDGSYGEYQSYSENGMNAPDDLVLFDLDEDDEDTKPVPNRSTKGGQQKNSQKGQHIEGRQTQSRPIQNVPGPHRTIHHASAPLTDNDRRNEPSGSTSPRMLTPINEEADPLDDADDETSSLPPLESDDEEQDRDGTSNRTPTVAPPAPVYRDHSEKKELPQDEQQDQDHTQEARNQDSDNTQSEHSFEEMYRHILRSQGPFDAVLYYHMMKDEPVVFSTSDGKEYTYPDSLEEEYPPWLTEKEAMNEENRFVTLDGQQFYWPVMNHKNKFMAILQHHQ
The following text describes a protein:
Function:
DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKTHITEHKFADFGLQPQVIDGLEKKGFVYCTPIQALALPVLLSGQDIAGQAQTGTGKTLAFLTATFNHLLTTPAAEGRAETQPRAIIMAPTRELAIQIFNDAEPLLASTGLKAALAYGGESYDKQLAKLQSGVDILIGTTGRIIDFYKQRVFNLNHIQAVVLDEADRMFDLGFIKDIRFLFRRMPEPKDRLNMLFSATLSYRVQELAFEHMNNPEHVVVEPEQKTGHRIQEELFYPSNEHKMALLQTLIEEEWPDRAIIFANTKHRCEQIWAHLAADNHRVGLLTGDVPQKKRERILEQFTQGDVDILVATDVAARGLHIPQVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISFACEEYAINLPAIESYIEHAIPTSDYDPSALLTDLPAPLSLRSSPQQRRTNTAGSRNSNNGGNRKPQQRRPRAPRPKKEA
The following text describes a protein:
Function:
Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates (By similarity). May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity in vitro.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MIPEFLVVSCTLAALCHSVPLSLQTEQQKVLVVSFDGFRWDYLYKVPTPHFHYVMKNGVHVKQVTNVFITKTYPNHYTLVTGLFAENHGIVANDMFDPVLNKSFSLEHMNIYDSKFWEEATPLWITNQRAGHASGAAMWPGTDVKIHESYPTHYLPYNESVSFEDRVAKIIEWFTAKDPINLGFLYWEEPDDTGHDVGPDSPLMGPVISDIDHKLGYLIKMLKKAKLWNNINLIVTSDHGMTQCSKERVIELDQYLDKEHYTLIDHSPVAAILPKEGKFNEVYDALANAHPNLTVYKKEEIPERWHYKHSDRVQPIVAVADEGWYILQNKSDEFLLGNHGYDNALAEMHPIFLAHGPAFRKNFTKEAMNSTDLYSLVCHLLNVTALPHNGSFRNVQDLLSSAAPKAIPYTQSTTLPLGSAKPGEYEQEESYPYYIGISLGSLIAIVFFVVLIKHLIRSQMHTLQYMQVEVAQPLLQA
The following text describes a protein:
Function:
May be involved in the transport of coenzyme A in the mitochondrial matrix. Very little is known about the physiological function of this carrier.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs.
Subcellular Localization:
Nucleus. Nucleus speckle.
Sequence:
MAAEHPEPPKGELQLPPPPPPGHYGAWAAQELQARLAEIGAPIQGSREELVERLQTYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLSGIPMPPPPMGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQAAVLMEQERQQEIAKMGTAVPRPPQDMGQLGVRTPLGPRVAAPVGPVVPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDTRSSLGQSASETEEDTVSISKKEKNRKRRNRKKKKKPQRVRAASSESSGDREKDSGRSRGSDPPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKMESSAVPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
The following text describes a protein:
Function:
Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity. Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus.
Sequence:
MSGRHRKPTTSNVSVAKIAFTGAVLGGGGIAMAAQATAATDGEWDQVARCESGGNWSINTGNGYLGGLQFTQSTWAAHGGGEFAPSAQLASREQQIAVGERVLATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAAVNGEPAPLAPPPADPAPPVELAANDLPAPLGEPLPAAPADPAPPADLAPPAPADVAPPVELAVNDLPAPLGEPLPAAPADPAPPADLAPPAPADLAPPAPADLAPPAPADLAPPVELAVNDLPAPLGEPLPAAPAELAPPADLAPASADLAPPAPADLAPPAPAELAPPAPADLAPPAAVNEQTAPGDQPATAPGGPVGLATDLELPEPDPQPADAPPPGDVTEAPAETPQVSNIAYTKKLWQAIRAQDVCGNDALDSLAQPYVIG
The following text describes a protein:
Function:
Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.
Subcellular Localization:
Secreted.
Sequence:
MKTPQYLTLLLLPISVLATPVLRGGNSSGNVKAAAGAGACAPMMLIFARGTTETGTLGTVAGPPLVAALGQVAGGANKVAAQGVPYPADVPGFLAGGDANGSKMMAQMISTAVTNCPDSKIVMSGYSQGGQLVHNAAKMLPAATMAKVSAVVIFGDPNNGSPVAGASAAKTKVICHTGDNICAHGTLILMPHLTYGRDAGTAAAFVKTATGM
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 200 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MPLFARLCQPQSRRMFSSISSFSALSVLRPQTGMLLNSSPLKTPSFTPLGFGLIGQRRWKSRGNTYQPSTLKRKRTFGFLARAKSKQGSKILKRRKLKGRWFLSH