lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion matrix. Nucleus. Chromosome. Note=Mainly localizes to the mitochondrial outer membrane. May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidences. Recruited to replication forks following replication stress.
Sequence:
MSRQNLVALTVTTLLGVAMGGFVLWKGIQRRWSKTSRVMQQQPQQPQQPQQPQPQPQPQPQPQPEHPQPQQQVPGGREWPPPEDDQLPFGALRAPRASWEERILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCALVRLPRLIYGGRTLPRTLLDILADGAILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMKQGNNILCNGLSLKSLAETILNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRDSYEEESTDQINWQKALERCRNMVDIPFRSKGLGRLVEEVNGEALESQLKPRNRKAKTDRMVPGNNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIITEEMLHEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDDLPIKLS
The following text describes a protein:
Function:
Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.
Sequence:
MARRISSQGKVTISVDEYSSNPTQAFTHYNINQSRFQPPHVHMVEPLPYDAPKSVGHTRFVCVSDTHSRTDGIQMPFGDVLLHTGDFTELGLPSEVKKFNDWLGGLPYEYKVVIAGNHELTFDKDFMAELIKQDYYRFPSVSKLRSEDFDDVQSLLTNCVYLQDSEVTIKGFRIYGAPWTPWFNGWGFNLPRGQSLLDKWNQIPEDVDILMTHGPPLGFRDWVPKELQRVGCVELLNTVQKRVRPKLHAYGGIHEGYGIMTDGYTTFINSSTCTVSFQPTNPPIIFDLPNPGNS
The following text describes a protein:
Function:
Involved in a reduction step in the biosynthesis of the plant steroid, brassinolide.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPTFEIHDEAWYPWILGGLFALSLVTYWACDRITAPYGRHVKRGWGPAWGVRECWIVMESPALWAMVLFYSMGEQKLGRVPLILLRLHQVHYFNRVLIYPMRMKVRGKGMPIIVAACAFAFNILNSYVQARWLSNYGSYPDSWLTSPKFILGATLFGLGFLGNFWSDSYLFSLRADEDDRSYKIPKAGLFKFITCPNYFSEMVEWLGWAIMTWSPAGLAFFIYTIANLAPRAVSNHQWYLSKFNDYPKERRILIPFVY
The following text describes a protein:
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPNYTVPPDPADTSWDSPYSIPVQIVVWIIIIVLSLETIIGNAMVVMAYRIERNISKQVSNRYIVSLAISDLIIGIEGFPFFTVYVLNGDRWPLGWVACQTWLFLDYTLCLVSILTVLLITADRYLSVCHTAKYLKWQSPTKTQLLIVMSWLLPAIIFGIMIYGWQAMTGQSTSMSGAECSAPFLSNPYVNMGMYVAYYWTTLVAMLILYKGIHQAAKNLEKKAKAKERRHIALILSQRLGTQVGVSLMLQSKAEKEKAEEAQKDSGYTSNQAGDANNLRRFGFSEPETSQFRVDPNSNNNLNVEGSLNTENDQNLGVIEEERSGFLSRRESNESYYPGPHPTAANSRRCSEMEKVSLLSESDGVPSTRPAKSYGRLSLRSRYSASESITTTHENDEKEVEKADSLQKLFADDELGSVLNFKEEKLKNTDSNNDSDTTSVILQRSRKYKKNKRPRSSRRSEHSTPRQIAKVKQAEGTAAQLIEESVPDDDQTETIEVKRTDRWVVSMKKRIARALIRRRSTTRPERGSSSNSDDSSSEVEGEEKPEVRNNGLKIPQLTVNNENRGETSSQPGRDRLAPPNKTDTFLSASGVSRKISTISTVITREKVISSIFAPIAVFNRGRKQTKAEKRAHKAFRTITFIVGFFAILWSPYYIMATVYGFCKGECIPSFLYTLSYYMCYLNSSGNPFAYALANRQFRSAFMRMFRGNFNKVA
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Single-pass type I membrane protein.
Sequence:
MARAAPRLVLGLLVLSLCCDACKKVTFHVPSVLEADTLVGRVNINECLQSAEHISSSDGSFKVLEDGSVYTTSAVSLSDEKRTFTILLKDLQEHVEKKILIDLETDEKKTRHARDTVLKRTKRRWGPIPSVMIENSLGPFPLQIQQVQSDTAQNYTIYYSASGPGIDQDPKGLFYIERETGNIFATRAVDREQYPSFQIICFASTPDGYSPEVPLVHTIRIEDDNDNAPYFTQDVFQFCVPENSKPGVVVGTVTAEDRDEPYTLHTTLKYRIVSQTPSVTPAFSLHGDTGVISVLSPQLDRELVSTYTLLIEVRDMAGQPFGLCTTGTAVIKIEDTNDNAPTFKQMQYETQVEENRVNVDILRISVVDADEFGAPGSTAVYEIIRGNDDHTFEITTDRNTNEGILCVVKGLDYENAKQRILVIAVNNEAPYMLAPHSQQVVQSTCTVTVNVLDIDEGPVFKPCFFRMDASECDDIGTNIGKYLAEDPETGNSEGICYKIPPGQCNWVNIDEKSGEVRTVRVLDRDLGEVKRGQCNITVLAIDRNGKTGTGTLQVVIQRCGRNYLRIPTTQYTMCRDRKPICLSVGDGDDTSYSMPLVYRVTDRSLGSMWKITQHNEKSVYLSPVGDIPFGTYTIPISVSDSSGRRGISEISVNYCDCVTPSDCGSPRSAGSVTLGVWAILAMILGSLLLLLILITICGCCGAGVMHRQVTDDCANHNLIISNTEAPGEEVMDHNIIPLQTTDQVGSGIKTGDQQTFEMVKGRGHTLESVRGGGHQTLGSVKEGGGQAMVDTCRYSYSEWHNFTHPRLGEKVHLCRQDEEQKHSEDYLLSYNYEGKGSLAGSVGCCSDQHEEEALDFLDQLEPKFRTLAETCIKR
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSATTAAVPFWRAAGMTYIGYSNICAALVRNCLKEPFKSEAASREKVHFSISKWTDGKQEKPTVRTESDE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MNTTIYNQLLVQIVENQFGKFVGQITKYLLVKPSTIFDLWRQCHQPYSKMYEALFVLLHHSILKYSNEEPVIISIDQNRILFSLRHSHFIALMQQKFGELAKEISITLITYGMLNFEDIFAVLQSKNIDVKESDLKAVFDEMVKEKYITRVNKNVVDLVQLERTSTPAPSFSTVKQNENVRRKGIRKRGKIDVVTENPIPKKVKVGIDLKAQTNLNSTTKVEDSDNSQPVWTVNIEVYNKETILYKLLDLVNKKFDNKAVPIIEKMWDLSAYGKTPVDFAILCQNLREIAPETIRKYLEMMSRDEPFIIAKNQSAFVSDTNSFKLQVDAATAFLKGVMIESCIQSKFGVIGASIHRVLKIKHILTDSQIADLLIGEGEEVKRGLYQMHQAGYVNGQEVPKSNIRGGKNSYYMWSINFSQINAILLSETAKSLMNTMDRLKLEISSKSALIAKYNEGVEIGQILLNEEENEEYMNLDRRQKMLLDGLYYLSGLFFCLKDY
The following text describes a protein:
Function:
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPAAACNVPVVCTEVPSKTDVLVCSEIVPYKSSDVPAFCNTEKVPGLKVPAKTEVPVHYEKVPVDVNNNCAVDDLISSMSAQLNISEPLNISEPLALPQYSNYSPYHYYVYFPYSPTDSVQGTSPIPASTPSTEVTSPSTGPNTYKYKIPSGTKIDGRIFVGGVTAGTSEQELKGYFGAYGTVKDVKIIFDKQGLTKGYAFVTFTSNEEATKLIKQADAGQLFLFKEKKLNIGPAIKKRVSLFPVFR
The following text describes a protein:
Function:
Putative gamma-glutamylcyclotransferase.
Sequence:
MGQAKKVSSALSKLFVYGALKYGQPSNSILASSGNGFAKFWCKATTTQKLPLVIATRYNIPFLLNKPGVGYYVTGEIYEVDDRMLNSLDNLEDCEEIYTREMHDMNIGVGEGTVPCWVYLLQKYPENLLSLRYLSSYENSTTHPYIMRHRRTHKHPAQDDLTYEAQN
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLKQDEELEFPGDRGITTDSLCYHFSLPIFVAVLFVFCGVLITGFKFSFIHPENEKGFRCGINNNKYGATDHDFTNFPYVILNGTQRYCSNQCTGRKFFRYCIPLDAKSMKKLPYKFKLVDDFLSYWIYIVIFASIVIVLSLPVYFICAKITSILFTVAIFASCILTGGTSVFAIRYQFYSSFAFLLSITISLIFIFIYFRKNISAISPMVSVSVDIFRRVPSLLHVAPILIFGGLFAFAFVVFGYFFSKGIGDAVVSDGRMKIESHGSLVWPIILFILAGQWFYEFLRTLLRISVSRIVCRLYFQKEPPSLSESIKHILKYHTGTVFLGSFIIYLLSDLVYLLKRLKKYSEKVQNRFVKFLINCLISLFIIITKIAGDINRLSFVFTALKGVSFWDSCKWAVDAIMDPNFAATEIIIYRVFWFIKISISLTFSAIAYFISSYIGLFYSTIFVSMTYIIIFYIVDSVETLLFASCESILVCVHEDVKDHGAQNAIAPPQLWEVVTLFGNCKPESQESTQA
The following text describes a protein:
Function:
May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
Subcellular Localization:
Secreted.
Sequence:
MWAGLLLRAACVALLLPGTPARGYTGRKTPGHFGAERRRLGPHVCLSGFGSGCCPGWAPSMGSGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPEAHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECLSASCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYRCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPLQHPPKMLLLLPEAGRPALSPGHSPPSGAPGPPPGVRTTRLPFPTPVLPTASPSALSQLLSTTVATPMPSASLLGTLGPPSQLQEKAVVTPSLPRGPEATQLAPGPSACWHLGAMYESGSRWTEPDCSQCSCEDGEVTCAKVTCEAVCSHPLPSGDGGCCPSCAGCFHSGVVRAEGDVFSPPNQNCTICVCLAGNVSCISPECPPGPCQTSLKSDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFTPCPELGCPREEWWLGPGQCCFTCREPTPMTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNQTFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTQCICQLGEVSCEKMPCQQACADSSLPPRDCCSSCPDFLEGSRGLSPGGVAELSKASRSPRGDPEAPVNCSSCPGPPATSSQRPAPQLLQLLLRTNLSNRQTLPSGARASPSPHLRLEGNFPGEPGASQPPRLSPGPSIFPGASSLPPASPGAPGPPPLTPEPSSSASRAHTASRRPTTALPGASALSTMGTSPSETPVTLLRPRRLSAALAATGSPGPQPPTTGTSREEEPTG
The following text describes a protein:
Function:
Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
Sequence:
MYMKKGSLAFDSHDSTLCLKVKLIRRWDRRLTIMRSLQMYNAKTSSSVLMCAWMFLWAGSPNLSAALLANAAPSPVPPTDDHGYDYYDYYGDYGDACHNWQTNIQEIHWEIATVGEQMVLRCPFSECWDGYTTTWYRKGVPLKLNPPADEITQSGDAGEQLQFTRVRQEDAGTYTCQMTNGTHAFVGNVQLEATNPPSITPPSMEPVDPPMLQKVVGENATFVCRASYGVVGPATFPQLYWVKNNTFVNNSSRVVLRRTSRTDSDGSLYMNVRLSIYHLQEADFGQYTCIAHTTFGWTSQNATIENDGSVIG
The following text describes a protein:
Function:
Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNITNKFQHTPIQGQPQSNLQAQQILLSQLHQGQAQQQQQQQQQQQQQQQSSAGVLGSGFQPSDNFGESLNQNIYQNNYQRAQPSLQQQFFPQFQQSQQQPSQQANNASQLQQPYQPAQQMVRQTSHFQQQQQQQPSSQQFYSQQQASVLQQQQQQQIQLQSAHQQQSSLLNMNSINVDNPNSVYWQHQQQLCQISRGSNVPHYYARQYASNSRKAKNPYSEVKSVGLVEATRSMVASLEDEEEKKKKPINYQGTPTTSAALLHNKKSTQDIFEDDSMEEQRMRLKTQGKQLWCQLDLSGQGLVNISSKLFHYDFLESLYLSNNKLNSIPSSISKLRNLRTLDLSHNRINELPEELGLCFNLRYLFLFDNNIKTLPYSFGNMIELLFIGIEGNPLEPSIANLIAEKGTKELIATLRDQTTVKRTPKPRCWLTLEDDGEVVDSDEVYKVEPESSDNFTVLSYNTLCQHYATPKMYKFTPSWALQWDYRKNLLEKEVLNYNTDIVCMQEVETKTFQEFWLPVMTANGYKGYFFSKTRSKTMSETDSKKVDGCATFFKNDKFSLIHKQNFEYNSVCMGSDKYKKTKDLFNRFMNKDNIALISYLQHKESGEKIAVVNTHLHWDPAFNDVKALQVGILLEELQGIIKKYRHTNSNEDIKNSSIVVCGDFNSVKDSAVYQLFSTGASKGHEDMNGRDYGKFTEDGFHHPFKLKSAYEAVGELPFTNLTPAFTDNIDYIWYSTPTLQVKGLLGGVDEEYTSHSIGFPDANFPSDHVPILAKFQLKKGKKNHSV
The following text describes a protein:
Function:
Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKASFLSAVVGAGLTHALPTIEAVGNKFFTSNGDQFFLKGVAYQLTPADPLVDTEQCKRDAALMEKLGANSIRVYHVDPSANHDGCMDVFEKAGIYPLIDLDTFDTYILPNDPWWNQTQHDRYAEVMDAFIKYDNVLGFFIGNEIIIQADQSLAAPYIKAATRDMKAYRDKKKYRKVPIGYSAADIAELRPMLQDYLTCGGNSSENVDFFALNSYEWCDPTKYAESGYANLQSMAKDFPVPIFFSETGCNVPGPRLFGDQNAIFGPEMVNDWSGALIYEWIEEENHYGLISYGPKLEPTATGANIEGGFTRAGTPTPVLPDFTNLQNQWATITPTGIKRSDYDPKHVSTRACPTSGVQGWLVNGNVALPTIGETLTTNAPRPAATQEAEVSQPAGSASPTSTKNPAPMNKELTGMSAGLVGVMLFFTFWL
The following text describes a protein:
Function:
DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MGHNDSVETMDEISNPNNILLPHDGTGLDATGISGSQEPYGMVDVLNPDSLKDDSNVDEPLIEDIVNPSLDPEGVVSAEPSNEVGTPLLQQPISLDHVITRPASAGGVYSIGNSSTSSAAKLSDGDLTNATDPLLNNAHGHGQPSSESQSHSNGYHKQGQSQQPLLSLNKRKLLAKAHVDKHHSKKKLSTTRARPAFVNKLWSMVNDKSNEKFIHWSTSGESIVVPNRERFVQEVLPKYFKHSNFASFVRQLNMYGWHKVQDVKSGSMLSNNDSRWEFENENFKRGKEYLLENIVRQKSNTNILGGTTNAEVDIHILLNELETVKYNQLAIAEDLKRITKDNEMLWKENMMARERHQSQQQVLEKLLRFLSSVFGPNSAKTIGNGFQPDLIHELSDMQVNHMSNNNHNNTGNINPNAYHNETDDPMANVFGPLTPTDQGKVPLQDYKLRPRLLLKNRSMSSSSSSNLNQRQSPQNRIVGQSPPPQQQQQQQQQQGQPQGQQFSYPIQGGNQMMNQLGSPIGTQVGSPVGSQYGNQYGNQYSNQFGNQLQQQTSRPALHHGSNGEIRELTPSIVSSDSPDPAFFQDLQNNIDKQEESIQEIQDWITKLNPGPGEDGNTPIFPELNMPSYFANTGGSGQSEQPSDYGDSQIEELRNSRLHEPDRSFEEKNNGQKRRRAA
The following text describes a protein:
Function:
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MRFLAIFVCLLLICGVFAEEEKKTSVVQITADNVDSIKSGNWLVEFFAPWCGHCKRLAPVYEELGAYYNDELKGDKVKIAQVDCVANQGVCQKFEIRGYPTIKYFKDGEAKDYRSQRDKASFIAYIDEMTKNPIIEVESQEQLEKYLRGNKVSFILVKSASDDSAYEQFKKVSNQIQDVGSPNTLVIRDKGVFEEEIKNNQLVLDDKSSTLFVYKDKEYTKFDATQNKQTLNSWVRVNQFPLISELTFSNQQMLTSAFGKIVMFVYKFKPSAEQIQYMKSFASENDVGAAPGDFGYTYIVEGTFVNWISQFGLEKFPAVLVFPEKMDIYYYEDTVNPMDKSSLTKFLSDVHQNKLSLKYLNRLGYIVDQIELFVMDYLYYIIGLSILLPLIFFYFFCRGDEESKNKDE
The following text describes a protein:
Function:
Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation. Together with pdc1, acts as a scaffolding protein sufficient for the phase transition of the components of the 5' to 3' mRNA degradation machinery to form P-bodies. Intermolecular interactions between the edc3 Sm domain and at least 10 helical leucine-rich motifs in dcp2 and pdc1 build the core of the interaction network of this spontaneous clustering process.
Subcellular Localization:
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Sequence:
MSVADFYGSNVEVLLNNDSKARGVITNFDSSNSILQLRLANDSTKSIVTKDIKDLRILPKNEIMPKNGTKSPSTNSTKLKSAETYSSKNKWSMDCDEEFDFAANLEKFDKKQVFAEFREKDKKDPAKLLVSHNKSPNRNYHHKQNVLGPSVKDEFVDLPSAGSQINGIDAVLSSSSNGHVTPGSKKGSRETLKKKPFVDENIPAELHTTTGDILKPITPEQLSQGIALAIAKTSTDIVVENAAQLLSQFVFSVLGGHKRLSSRNHNSQPLVCILVGSHDHASAAVAAGRRLCAIGIKVVLRLLTPFNVDNRQLLMFQAAGGYIPTENFDQFLNKLTSPIELVVDVLTGFHPSIDKNSHALIQWANDLNVLILSVDIPSGYTVQKKNTAILPKWTLALGAVTTTLAQAALVKQAAGVSVFVGNLGTGSQTWAELGILESQVTGQYLAQISCTSTN
The following text describes a protein:
Function:
Required for maintaining cell viability in nitrogen-deficient stationary phase (G0) cells.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MTKAKKSRAYQEGDIRYKCDFQGCTKSFTRKEHARRHFRSHTNSKAFICPHCSSSFTRSDVLNRHVNQKHVKQNDAGSQTHPKHDKTLISSSDQELPFPSYVEADVQDAAYTDLKSHIDQPILPDQPIISDNFNEGLQSAIAQTGNNYMFTTSRRNNSISGSITIPESDQQINLQNKFLSTPSIKNNANKSLSPQDSISIFGTSPFNAYQQNTDNFVCWLFDNMEKDAPTESVSNFTDGINAKQLNLMPVLDSPTIDFLSSHFRVDDKLVAKDLLSLSAYSSLIQVMNNNYQLSEEALQYITRSRVNLWIAHYWKDFHPRWPFLHRGTLKVDEAPVELLLAMITMGMHFVGDAFAYSIAVSIHSTLRFSIYTHPDFKPPASLWVYQALLIAEIFEKMTSTVEQHNLSQIFHGVTIESMQNGLSSKDTVTEKIPKNMTGTNIAQHKWHQWVDREASKRIAFFSFVLDSQHVILFGYRPLIDITSVGLPLLCDEALWNADSYEAWTSLLNENDPPHFFPVLKMFLTNEHLPPKLSPWNMMIVLHGLTTIGWILSRENLGIVENIMQNNGTNLKNWRILLKASYKFWLRTYRVFFLNNGTLPLNHPYVRGCLATYELAHISLHTNIVALQTYAKSIVSTSRRLYASTSRYVSAWLASDDSEVSIKHAVDMVEAFLGGDMEYDVQNETGLHRPWCLYVSTLILWAYGYVSDGRCEMLEPGNNDCKSQLNAYLMQMRTGLSEKAKDHVYVRSKTLPLLKCVIDVLCPARWGLLVDGVRILSKLVQL
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates DMC1-dependent homologous strand assimilation required for the resolution of meiotic double-strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MAPKKKSNDRAIQAKGSEAEQLIEDYLVSQYKPFSVNDIVQNLHNKVTKTTATKALENLVNEKRIVSKTFGKIIIYSCNEQDTALPSNIDPSQFDFETVLQLRNDLIELERDKSTAKDALDSVTKEPENEDLLTIIENEENELKKIESKLQSLQDDWDPANDEIVKRIMSEDTLLQKEITKRSKICKNLIATIKDSVCPKNMNEFLEEIGFEDI
The following text describes a protein:
Function:
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
Subcellular Localization:
Apical cell membrane. Basolateral cell membrane. Cell junction. Cytoplasm.
Sequence:
MEDGGGGGGAAPRGSGQSSGTGSGGGGIGLARELGRAFAHHRLYLKRLQQNLSETQKFFSDIQCSYDRSFPPSPPVPGGAEQGLGADGDVSEAVLRAGHLSCISFPPHEEEYLQLIVNCFPCIFILGQDCNAKCQLLNMLLGEQILPTTKRGSEDSCKRRRLHFTNGKQTQVSLALPGQYELVHTLASHQGKWETIPEEDLEVHEDSEDPAHILAELEVTMHHVLLQEVDIVVVPCRGFQPLVDSLGELVNGVLPVVIFAINNDELSEVDEEELRNIRERLSLPIFFFKVPKLGSKLISPHPSSKKRMETARSSLHRQLVDLNYLSDCHYNCGTSGLDAKAQSMLVEQSDKLRQLHTFTQQVLQMHLVDAATILNLVHCRCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNIMKEELLDDAANMEFKDVIIPENGEPVGTREIKCCIRQIQELIISQLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSTVTRMLWEQIKQIIQRITWVSPPAVTPEWKRKVAQDAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLVHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPSRRPLLGIVQPMLQGIMDRLCKSNSEQPSKGLDDST
The following text describes a protein:
Function:
Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSHTIRDKQKLKARTSKIQGQVIALKKMLDEPHECAAVLQQIAAIRGAVNGLMREVIKGHLTEHIVHQSDEARREEDLDVILKVLDSYIK
The following text describes a protein:
Function:
Involved in the regulation of the G1/S transition. Increases the DNA binding activity of E2F proteins after heterodimerization.
Subcellular Localization:
Nucleus.
Sequence:
MDDPYLEDSPSCEQSPVATPSNASTSGSARGLNQSAVKQRNASADVVDGTTRKKVSRMPGGGLRQFSVMVCKKLESKGSTTYAEVADEIIEEFATAQTNTARSLDEFHEKNVRRRVYDALNVLMALDIITREKKEISWKGLSTTTQAKNLEELKALHVQLMTGIAKKAAYLKDLEEQIAGLQNIIERNQQLLKKSSAPKEGFTLPFILVQTSPHATVEIEISEDMQLVHLDFNSTPFSLHDDAYVLKLMRYYQRPESRNTSQSSSIHSSSSSCKATVKPFYWNSETETPR
The following text describes a protein:
Function:
Component of the glideosome complex, an inner membrane complex structure involved in parasite gliding motility and host cell invasion. During the asexual blood stage, may play a role in the assembly and anchoring of the glideosome complex to the inner membrane complex. During the sexual stage in the vector mosquito midgut, protects gametocytes against host alternative complement pathway-mediated elimination by interacting with host complement inhibitor factor H. Has phosphatase activity towards nucleotides such as ATP, vitamins B1 and B6, phosphorylated sugars, glycerol phosphates and inositol triphosphates. However, the phosphatase activity is controversial.
Subcellular Localization:
Inner membrane complex; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=During late-ring to mid-trophozoite stages, localizes to the endoplasmic reticulum. During schizont maturation, re-localizes to ring-shape structures at the periphery. Localizes to the apical end of the developing merozoites and then expands further around the surface of the nascent daughter cells. During invasion, localizes to the interface between the invading merozoite and the host erythrocyte membrane. Localizes to the inner membrane complex (IMC) in intraerythrocytic gametocytes. Following gametocyte activation and disintegration of the IMC relocalizes to the macrogamete cell membrane.
Domain:
The C-terminal transmembrane and cytoplasmic domains are required for the trafficking of the protein to the inner membrane complex.
Sequence:
MNYCKTTFHIFFFVLFFITIYEIKCQLRFASLGDWGKDTKGQILNAKYFKQFIKNERVTFIVSPGSNFIDGVKGLNDPAWKNLYEDVYSEEKGDMYMPFFTVLGTRDWTGNYNAQLLKGQGIYIEKNGETSIEKDADATNYPKWIMPNYWYHYFTHFTVSSGPSIVKTGHKDLAAAFIFIDTWVLSSNFPYKKIHEKAWNDLKSQLSVAKKIADFIIVVGDQPIYSSGYSRGSSYLAYYLLPLLKDAEVDLYISGHDNNMEVIEDNDMAHITCGSGSMSQGKSGMKNSKSLFFSSDIGFCVHELSNNGIVTKFVSSKKGEVIYTHKLNIKKKKTLDKVNALQHFAALPNVELTDVPSSGPMGNKDTFVRVVGTIGILIGSVIVFIGASSFLSKNMK
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MASPKKARKPRARRPLLLRRAMLHASLCFLVGLLAGLAPAARWTAAASAHVSRALHAVDGAFDRAVLLLRQQQRQLRDGRVHVAVLPSPAPGPPALEPLRQPQLLLVVTATERSDPERRAAGLTRAAHALRLVPPPVLWLVVEPAADALPTARLLRGAGVAYRHLAYPENFTADGVGMGKERHHQRNLALEHVEEHRLAGVVLFAGLGDVYDLRFFDQLRQIRTLGAWPVATVSERERRATVDGPVCGGSPWAVTGWFSTAGAPTVRARPPAGTLDVARFAFGSALLWHPSRWDSFPVSEPDASQDSVKFVQRLAAEDYNKSRGMPNRDCSEIMVWRGDQFVAT
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKQLRNIVAPIFLLCLMLVAGLPVFAQTQEDVTPQEQKENTVDVKEIVFGHIGDSYEWHITTWGKTHITIPLPIIVYSSTTGWHTFLSSRLAENGGTYEGLSVAPEGSKYEGKLVEYNAAGEQVRPWDISITKVTFALLFNSVLLLVIVLSVAQWYRKRPQGALAPGGFIGFMEMFIMMVNDDIIKSCVGPNYRKFAPYLLTAFFFIFINNIMGLIPFFPGGANVTGNIAITMVLAICTFLAVNIFGTKHYWKDIFWPDVPWWLKVPVPMMPFIEFFGIFTKPFALMIRLFANMLAGHMAMLVLTCLIFISASMGPALNGTLTVASVLFNIFMNALELLVAFIQAYVFTMLSAVFIGLAQEGAKVKAE
The following text describes a protein:
Function:
Probable GTP-binding protein that may be involved in cell development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSLHLVDADGHLHSEKRLKEYLTTIVAPSVSQSGSAATADDGDGDSTLEAIGVNYHVVGVFGGQSSGKSTLLNHLFGTDFQTLNEAVRRGQTTKGAFMARANDALAGVEASSAAVVADRLASGAADRSSCLNRAAAAAATKDVADGAHGASRTASLMLVLDFEGTDGLERGEDQCFERQLSLFGLSIADTLIINMWAVDVGRFNAANLNLLRTIFEVNLQLFSHDKYEAEEKPTLLIVLRDFTEDDPAPSLATVRKSFDTIWEGITRPAQFAGASIDALFHLKYYVMPHYKLQKTEFMTSVETLQRWFSDSQCPDYLFSHRAMFRGVPLEGLPAYLTSCWEAIRTSKDLDIPTQREMLAQHRCKEAKMQELKAFRHFARNYEDRLLHGEMLLRLSEVLDEEMETRLTSFYRQTKLYNSDVVGQYANELETELVNATMRVLNRLSKAIAAEVLSNAEPRVLNSVEESLRQLLKSAQTLPFSAGEGPGAAEAAEVNDVEGDAAHLVGAQRMDSPACQKLVRSFWRSLSRHVNEVVAEVAAMPPRAHLYGRYVALIAQDPTTRLNVLNIVTDALFQKVKSRMVSMADSACDTMHAGFERSLTHNSDGTARFFATTKGLQKAVPAATQAGVVVLGSLFYFRLKLVAAADDDGIGADAAGTALPQSRSARRVRQDRHRILFNDNDAEAAFYLSYSTFDTAPKYPYDVPVRSADCDGEEAGAAADCILLSQQATVRAYELYRQKCDFTTQLQLRTIEAGKQRLPAWVIPALFILGWNELLYVLTSPALLVLVVVICAVFFKQFFVSQWHAFEETGPASVVIPTKTVIHTLSTLVRPLLDYGPGPRTERTERSHDAAAAVEEMSHVEATCTHVDPTLGSANLPAAPATMRHRTSRKLD