lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MHLAQLRQPLTRAAANSCHSVCRLPTTHSSVSATAILSEQFAHLRIGPSSSNVAVEGRRYASVKAQGAYRLKPKRTIPKKLGAKKTGDQYVIPGNIIYKQRGTLWHPGENTIMGRDHTIHAAVAGYVKYYRDPQLHPDRQYIGVVFNRNDKLPYPKDAPRKRKLGLVAVPRKVEEVEKPTMSASGLPLFVTRHETIEIPPPAVTTPAAAGKAVKGQGARVSASGAAAVPASSSTISASASSNSNNGGSSVIAELIKEKLAARAEYNARQSALRKLQQQKMLARRGTRVLRLMNNYSYRETNWEIGRLIGDPGSVPGTEKVGSRKAKFRARRRRRNTFLLGIKERKLAKADRREEYRRRVREKREQRLVQRKEFLAKQREAKKAREGGAAAEKSEKKEVKAEKPAAAAPKVEKPKAPEAAKKESKPKVEEKKAAAAEPKKDSKTEKKD
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSARTRSSRRGEVSDLKGANGYAWEDEYQRSWDIVKDDEQGGNSFEAMVQSIIENRKKKIMKNPSTPFQRGIIRTLIIIIDGSSAMSEKDLRPTRLSMTLNYLQEFVVEFFDQNPISRLGIILMRNGVANLVSEVSGSPQYHVDKIRNLKARQHNRFEPKGDPSLQNSLEMARSLLKFNFGSTSNNSKNSKEILVIFGALFTSDPGDIHKTIDSLVKDEIKASVIGLSAQVAICQELVNRTNNEPRNSQSKHYGVIMNESHFKELLMESVTPLPLTESEKQIQESEQNGVPVLRMGFPTKVQPTLTSAIGGSDYIVEFPHLNASFPTQGSEDSKDVVEIQTNKPAAAVATTSSSVIGYQCPQCKCKVCNLPTICPVCGLMLILSTHLARSYHHLVPLAPYKEVKVSPIYDSTYCFGCQLKFPEGVKLGTHKGTLESMTSSRYRCLKCSQDFCINCDVFVHEVLHNCPGCENN
The following text describes a protein:
Function:
Antibacterial peptide mostly active against Gram-positive bacteria.
Subcellular Localization:
Secreted.
Sequence:
MRGIYICLVFVLVCGLVSGLADVPAESEMAHLRVRRGFGCPFNQGACHRHCRSIRRRGGYCAGLIKQTCTCYRN
The following text describes a protein:
Function:
Involved in the control of sexual development and cell growth under stressed conditions. Phosphorylates AGC kinase gad8 at 'Thr-387', activating gad8 kinase activity and promoting sexual development. Phosphorylates AGC kinase psk1 at 'Ser-248', activating psk1 kinase activity and promoting phosphorylation of ribosomal protein S6.
Subcellular Localization:
Cytoplasm.
Domain:
The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
Sequence:
MRNTHNPNETEASEDAENDTQSESDLSFDHGSSEKLNRASLPKTQNSAIPQSNALNTTPNESTSQIDSSPKIPSAVPHISTPNPSSGASTPNIKRVSDFKFGEILGEGSYSTVLTATENSTKREYAIKVLDKRHIIKEKKEKYVNIEKEALCILSKHPGFIKLFYTFQDAHNLYFVLSLARNGELLDYINKLGRFNEICAQYYAALIVDSIDYMHGRGVIHRDLKPENILLDDNMRTKITDFGSAKILNSSHGSHEEDTHHADKPQAHSRSFVGTARYVSPEVLSDKIAGTASDIWAFGCILFQMLAGKPPFVAGNEYLTFQSILHLSYEIPPDISDVASDLIKKLLVLDPKDRLTVDEIHQHPFFNGIKFDNTLWELPPPRLKPFGHTSVLSLSVPNASNKHENGDLTSPLGVPSMVSASTNAAPSPVGTFNRGTLLPCQSNLEEENKEWSSILQDDEKISKIGTLNVYSMSGINGNDAFRFFSSLFRKRKPRTFILTNFGRYLCVASDGEGRKTVKEEIPIKSVGMRCRMVKNNEHGWVVETPTKSWSFEDPNGPASAWVELLDKASSISLPFGNHSVTSFSRSIARSAV
The following text describes a protein:
Function:
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MIGLQFACEIEGRMNGHAKNMHLKKSMKSIATLLSFLLLMAVHSTRMVGASRNQPCRKTLQRTFKLAKVVQSEASELFIIYKASQGEGSEFLCTAPVNNIPDPNISGLEASERISSIYTHLQSFIPHLKRVYEQQTDLQLPTSPMLSKLLGVSANSRNLALSINDFYHRAFPNLPLPEPAGGPTTLPPPLNVFQQKVYGCMVLKTYKEFTSNVSKEFKSFRGKVCRRRMKTNALF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, UBC28 and UBC29 in vitro.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MVVMSRVSFYSSFLLLLLEVVVASSEFDDEGRTSFSPTTAIIMIVLVSVFFALGCISVYMRRCLQHALGMDSGGGPGNWLNVRQTTEPGLDASVIETFPTFPYSTVKTLRIGKEALECPVCLNEFEDDETLRLIPQCCHVFHPGCIDAWLRSQTTCPLCRANLVPVPGESVSSEIPGLARETGQNSLRTPIDDNRKRVLTSPDERLIDSVAWTGNQSMPRKSMSTGWKLAELYSPASSPGQPEENLDRYTLRLPQEIHDQLVNSSLGKQGSKGQLALPQERSSVRGFRTGSLGTEKNYFYFERFDQDGRLDRRPFSITPPYHTRSIQSPDEIINASGNYQDRAGAPKGLLLAIRSPFDRLFTGKKNAGERSYLQSGDASPV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MIPQSVRRVVAAAPQSPVVSSLAASSAPRAGASYILSSYQPNALQKRRYSSSKPSSPDDGSSRAFAARASVPAAGTSKTPGEKRKRKAKEPVMPPLPSVPSTRHIKDEALALSTFFALHRPISVTQLLPKTVTEESFAEIFNHRKGHKATDVLSTLSQAVHDLESPMSGLRLSDNDVEDGSTKISLKHPDGTESDVYFQLNSMSGHFLPFNPPPPPEPIAEVDEAAAEAEASAAIAEEIAATAEQEPETRVYKAVVTIEETRDTNGQYKIMAHSPQLVEDDAVQPRSFLERLALRQIRYEEARQQQGIMHAISVRRQKKLKIKKKKYKKLMRRTRNERRKQDRL
The following text describes a protein:
Function:
Has a role in meiosis and septation.
Subcellular Localization:
Cytoplasm. Note=Localizes to the barrier septum.
Sequence:
MSRSICTLTCILPTFSMDYWNQECVELSQVENLFTELASRLELLEMNSKNVLYRLTIGTNPDRNWEAIAFIREFFDSAKHGYVIPKHEIRNRIRLLSEASLISCLRWLLHRIPGGVITWSTYKLFDEAETRANYPVRGFDIFMKHATKHSCHFNILKCFLKLLMSLSAKLAVSSNSSTVSSLELVSQIASIWAFDWPMMNLQETFIYWDRCTNACLRLLLCYIRYTNKSSETGFSCLPSALQSQLQSFNYPPSLKKLNDAKAHVFTFSMNYYMTRDPLEMIQIVTKMNIPDHLTATLPRSSDDIQNDCLFALRQVSKRSSYHSVFSAQESAWTDFIKNGFDHPILPTCTQETVYSLLTGNDTACVYPFPNKPYRLPDVDFEIFSHCSFESLTTVTTNTNIWWVWAESRCTEIPESKRTVFPNCTMLIDKTGRLIILQQTVPQKPVALTASSNKRKNRIFGKIRRSFKRILKPRKINKTVKIMSNSQRRSCQSVLSEGNRTILLHLADQMNACSLQTKSRESIKTLKLIEEKDEYWEPETAGYFNTIVGWADQRKSLYDEAVIKINHSNMLNTLPPTSQGATSTTVSSASSNFLSSSCTPIDDTNSVTGSTLSCSFDEMKLSDKIDDANSLKDDDFIQGSKKDFFEMNLNHSSYQNKDELKPFQLLVKHAFKPPSYRLIRPPLRDWQSSDTLSSEMSKSISSSRSSPFSLEQTISKIQNKL
The following text describes a protein:
Function:
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. It is able to hydrolyze penicillin and imipenem, but is much less active against cephalothin, cefotaxime, meropenem and ceftazidime.
Subcellular Localization:
Periplasm.
Sequence:
MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLTQVSGPVYVVEDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPELIDHYEALIKAAPQS
The following text describes a protein:
Function:
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp1 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp2 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAYQNNGGNFRGPRHSFNGQPSGRGNFQRHDPEEDFKSKLTSLIVRIGDKATSSLESNIDALANALLADIPKQSSLIQDILFKCVSSLTYKTPIYATLVGLINVKNSEFGKEVVCRLVDEIFSAMEKKKFHNAKLLIRFIPELVNANVLTINAIFELYETLLSVLNTSDYTPNKADYFVFLVLSTIPWIGEHLSHNHSGQLDAVIEECESYIQSRSTGDKKFYQAYNNGYTDDRLESMLKQIKSLRDCDQPWIVNGILRPYKHFNETLTSSSSQQHILPTIHFPEDEKLEYPNNLNKPLFRVLSNDNNNSVERYIVEDYIIDILSFFNSDHKECSKFIYSLPVENEIDDIVVETILGEMFMLPEPTFKPIYYSVLFVDFFKSQPSVIPVFAYAINLLFENIHKLDFEVMDRFALAFAHHLSNFDYKWIWSDWAQSLVPPTAAAAAAAATTTVEGSTSNENKEDSTATTTAIIEDENQIRNRELRIIYIKRVLSSLCRLSYLEKIKQNLPSEYHQYLPPSPAPTFKFLNADNPEEESKELIAESHKLLLSFKTKEPLENIISHVANIPSHINIVELLTKCILQIGSTSFSHLTYAIERYITLFKTVLKSQDDRQECIRSIFEFWKLSHQHIVIVVDKFVTFKIIYPIDTVTWFMKPENIDRFITEPFTWECLHNSIQKTIIIIQTLTLDLEENQSQEKEFKLNTSISEQQLLLAELVKGLGSILSSEKYQLGASSKLLISGQLKSIIRKYFNQMKPVIQSQPQLSNIINQYTQ
The following text describes a protein:
Function:
Diterpene cyclases that can form multiple diterpene products.
Sequence:
MTDPAVTPLAFSIPQLYCPFPTAIHPEVDTLTRAGMDFMTHHGFCNTEADRLVVANIDAGAIVARWYPNPDFPVDRLQMVTDFLYLYFLIDDLRFEVINSDTGLAGPIALFAQHLDLWEYPQAHRREELDLFHQAIHDLASRMAELTTPTKAARMRRSINGWFLALLREIALFNDDHAVMAEEYLPIRVVTVASRLMIDVNGFICPAEVPGDEWYSLKVQAAAEAAMSVCLYDNELYSAGKEQWLKSRATAHDRRPRNLVALIQAQTGGSTEHALQEVAEYRNRTVCLYLNLRSQLEKTASPALLAYLSVLDGVISGNLDAHATSSRYHNPDGHHPHAIAFTPLRTTDECSARAHTPIAPPIAWWWEQLDQ
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane.
Sequence:
MKKLLIASLLFGTTTTVFAAPFVAKDIRVDGVQGDLEQQIRASLPVRAGQRVTDNDVANIVRSLFVSGRFDDVKAHQEGDVLVVSVVAKSIISDVKIKGNSIIPTEALKQNLDANGFKVGDVLIREKLNEFAKSVKEHYASVGRYNATVEPIVNTLPNNRAEILIQINEDDKAKLASLTFKGNESVSSSTLQEQMELQPDSWWKLWGNKFEGAQFEKDLQSIRDYYLNNGYAKAQITKTDVQLNDEKTKVNVTIDVNEGLQYDLRSARIIGNLGGMSAELEPLLSALHLNDTFRRSDIADVENAIKAKLGERGYGSATVNSVPDFDDANKTLAITLVVDAGRRLTVRQLRFEGNTVSADSTLRQEMRQQEGTWYNSQLVELGKIRLDRTGFFETVENRIDPINGSNDEVDVVYKVKERNTGSINFGIGYGTESGISYQASVKQDNFLGTGAAVSIAGTKNDYGTSVNLGYTEPYFTKDGVSLGGNVFFENYDNSKSDTSSNYKRTTYGSNVTLGFPVNENNSYYVGLGHTYNKISNFALEYNRNLYIQSMKFKGNGIKTNDFDFSFGWNYNSLNRGYFPTKGVKASLGGRVTIPGSDNKYYKLSADVQGFYPLDRDHLWVVSAKASAGYANGFGNKRLPFYQTYTAGGIGSLRGFAYGSIGPNAIYAEHGNGNGTFKKISSDVIGGNAITTASAELIVPTPFVSDKSQNTVRTSLFVDAASVWNTKWKSDKSGLDNNVLKSLPDYGKSSRIRASTGVGFQWQSPIGPLVFSYAKPIKKYENDDVEQFQFSIGGSF
The following text describes a protein:
Function:
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Sequence:
MSESQSHINPLLLSTETAGDTYLVNPLTGTSQDGVSPLHETVSTAAPSTTPSASLHSLAPPPELSYRTRSQLDDAVQKWALEHGYAINKTNITTHNGEDRATGVDKRKPTPLAHAKLHARRRLACTPARQSPSHRTQAWVLWEVFFSFKKKFFQNKKKEKEKKRPTRRPGGIPPGRRYNLAGREDSLQVGEVVQPRRPGDFYCGFPDGVLPNGLNVVKFSAMHEFQNIHAISKQKIHDFVRGHFYGHYDFDLDNTLYFFTAGRYDYRNKGVDMFIESLARLNHKLKTMKYKITVVAFIIMPAATHSYTIEALKGQAVTKQL
The following text describes a protein:
Function:
Involved in peroxisomal proliferation. Promotes peroxisomal duplication, aggregation or elongation without fission.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MNDTVDKLVIFLAKRDGIDKLEKTFQEDIPICFQACKLACGTSGLSRKAFRTGRFLTGFNALRRNPGSTLTLRLLAVLSNSGEMVYFFFDHFLWLSRIGTVDANLAKKMSFISAFGEAVGYVFFIIADFILLNEGLKAEKKLRSSEGKDNEKEIQKLKSDRIMRLMAVAANVADLIIALAEIEPNPFCNHTISLGISGLVSAWAGWYRNWPS
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Late endosome membrane.
Sequence:
MKYLIFNHITNLCKLVGYRNLQFVSSCKTCSIKWYYLYSLQGFFENLDQFVTSWYLDPILWFALIGVIIFVMATLGCIGALRENTCLLKTYITVLCLMLILEIGGGVALYIFRGQIEEFVANRIDDVAITNYRDNADFQDIIDGFQTGLKCCGVNGYDDWNMNVYFNCTTLVGRYNPEACAVPFSCCVPDPADTTDVINTQCGYGVRAEDQRRSLSDQIYEQGCISAVKAWLSTNVVVVAVSAGAILLVQILGFGFATSLNSDIRRQIASSASSARPP
The following text describes a protein:
Function:
Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.
Sequence:
MSSQNIKLQRKNSMTYFDLIAWITENKKAIEGCIIDNVFLIQNTQNTYILKLHCSGRDQELIIEPSKRINITKYNYPKISSTKITELRRLIRGDIITNMYVLNKERILILKLKRDDKKVIVELLPRGVLVIADKDGKILFASEYKEFKDRLIRIGEIYKPPPSIEPNIDEIEKLIKKGNIAKGLGIPQEVANYLSLQDSTPDINVIREKIRNLEISIINGEIKPCLVEDTTVVPFYLDGCKEYQRFNDAIDDYFYTITQKELSEKTSKKISEEKQKIIATIKQIEDSIKDYEDKENNYRQLGNFILSKAYEIDQLLLNNRAKSKKVKLNVDGVEIELDTSLSATKNAMRFFDEAKEYKRKIERALKSLEELKEKLAKIEKQEIEKQNEIKLTLRKKEWYEKYRWSISRSGYLIILGRDASQNESIVKKYLRDKDIFLHADIIGAPATIIITQDNKTISEEDIYDAAVMAASYSKAWKVGLASVDIFWVLGNQVSKSPPSGEYLNKGSFMIYGKKNFIKNVKLQLAIGLILSENGVSVIVGSEETISAKTKYYVVIAPGDDDKERITQKIIKVFSRALPEINGLNALKTEIEDKIPGKSKIVKTSITYNS
The following text describes a protein:
Function:
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity. However, because of the low catalytic rate, the question remains whether L-cysteine is the actual biological substrate.
Miscellaneous:
MISCELLANEOUS: Catalytic activity was tested towards all 20 common amino acids, but was only observed with L-cysteine.
Sequence:
MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAATDHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD
The following text describes a protein:
Function:
Required for spore wall assembly. Required for proper deposition of the two outer layers of the spore wall, the chitosan and dityrosine layers. Negatively regulates GSC2, an alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Participates in a developmentally regulated signal transduction pathway that coordinates cytodifferentiation events with the transcriptional program.
Domain:
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Sequence:
MNCTLTDNTRAINVASNLGAPQQRTIFAKERISIPGYYEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPYDGLYCYQELIDYDLAKVIHSSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISHPFLNEVRKPDDEPVCLQGPFDFTYESELNSMSKLRDYLVEEVKNFKTDLSSSSL
The following text describes a protein:
Function:
Required for 5.8S rRNA and tRNA processing; associated with RNase MRP and RNase P.
Subcellular Localization:
Nucleus.
Sequence:
MDRTQTFIKDCLFTKCLEDPEKPFNENRFQDTLLLLPTDGGLTSRLQRQQRKSKLNLDNLQKVSQLESADKQLEKRDYQRINKNSKIALREYINNCKKNTKKCLKLAYENKITDKEDLLHYIEEKHPTIYESLPQYVDFVPMYKELWINYIKELLNITKNLKTFNGSLALLKLSMADYNGALLRVTKSKNKTLIGLQGIVIWDSQKFFIMIVKGNIIDEIKCIPKKGTVFQFEIPISDDDDSALRYSILGDRFKYRSVDRAGRKFKSRRCDDMLYYIQN
The following text describes a protein:
Function:
Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Catalyzes the decarboxylation of the 3-methylglutaconyl group tethered to PksL to a 3-methylcrotonyl moiety.
Subcellular Localization:
Cytoplasm.
Sequence:
MTHSVVELIEIESAIIQVKMQDRTHKNAFSQELTDDLIQAFEYIRQNPKYKAVILTGYDNYFASGGTQEGLLRIQQGLTKFTDDNLYSLALDCEIPVIAAMQGHGIGGGFVMGLFADIVILSRESVYTANFMKYGFTPGMGATFIVPKKLGFSLAQEILLNAGSYRGADLEKRGVPFKVLPRAEVLDYAVELAQELAEKPRNSLVTLKDHLVAPLRDQLPRVIEQELMMHEKTFHHEEVKSRIKGLYGN
The following text describes a protein:
Function:
Involved in redox-control of magnetite formation; oxidizes Fe(2+) to Fe(3+) or to mixed-valent Fe(2+)-Fe(3+) oxide minerals. May control magnetite crystal size and number (Probable). Overproduction of MamP leads to more crystals than normal during exponential growth of normal size; in stationary phase crystal numbers become wild-type.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 20 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Not seen in magnetosome membranes.
Domain:
The dimer forms a pocket of about 8 X 15 Angstroms, lined with acidic residues, which may bind 2 Fe(2+) ions.
Sequence:
MNSKVALLVVGLAVVLALVIGRQGPVAPQATNTQSQAVAAGPVAAPVAFPQPLYPQAANVAMPVEPDPAAGGGTAPATESPLPNFVPRKLKVFEGHWQGMDGRLMTEELARKLNYPRGLQGVLLGEVTLNAAFSGLLAGDLIVRIDDTPVTDMESFKAASRTVANRSDARISVLRKDNRPGAPVVRKLTVVLREAEGGLGFAQLEGAPMILAGDPRPHGYRGACTDCHPIGQGFELTPDPDLISLPPPTITRDMVARSVNPHEVRGPCEACHVIK
The following text describes a protein:
Function:
1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.
Sequence:
MLSRIASCDSHGQDSSYFLGWEAYENNPYDQLHNPSGIIQMGLAENQLSFDLLESWLASNQEAVELKRNGESLFRELALFQDYHGFPDAKKELVKLMARIRGNKVKFDPNKLVLTAGSTAANETLMFCLADPGDAFLLPTPYYPGFDRDLKWRPGVEIVPIHCSSSNGFRITISALENAYQQAQTLNLKVKGVLITNPSNPLGTAMTHQELNHLINFSKSKRIHIVSDEIYSGTVFDSPSSSFISIMEAVMDRNIDESDDLWSRIHIVYSLSKDFSMPGFRVGMIYSNNERVVSAATKMSSFGLVSSQTQYLLSRMLSDKKFTCNYMKENRKRLRKRKEMLVSGLKVAGIRCLKSNAGLFCWVDMRHLLVSNTFEAEKELWKKIIFEVGLNISPGSSCHCNEPGWFRICFANITEETLQVALQRIKVFAQSCNPQMLLLQRRSIIGKWISKLSSSSSYDQEPDR
The following text describes a protein:
Function:
Involved in the control of the dynamic organization of the cortical cytoskeleton. May play a role in the organization of microtubule arrays at the centrosome through interaction with centrin 1 (CEN1).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes to cytoplasm and cortical cytoskeletal structures, including the preprophase band and the interphase microtubule arrays. Recruited to cytoskeletal structures by LNG2/TRM1.
Sequence:
MDDYTREMMDLKTLVTRTLEKKGVLAKIRAELRASVFEAIEEEDRVIENNEGLPPALLGSCNDRARQLHASPSGRLLSALICEYLDWAQLNHTLKVYQPECNSAKDSWKSEIRDFSINNGYELNRNEDSRPLLLDVLEGFLKFENMTQVMGGSSRRESETESSLSLDTRNPPRRSSASDSLPHQRRSVSASQASGAATSGYRKDESNWRYDTEDMPEEVMRASTALENLQLDRKTRNLTSSWRNVKDGTSEEEEGKD
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MASNALNFELTFRDAGTLKKIFETLVPLVKDTPVSITDHGLSIETIDNGRIALISLHLPTQFFKNFRCERACSLGVRTASFLKVIKFCSNDDLVTLSQRSNSSDQLDILVESRKYSQTMNFSLRLFRSDADQIDVIRPEFDSTVSIDSGRFAGMVRDLMGIGKTCRIFTKSADTTVSFEVMGEDTKCVITLGMSGYVRTKEEDAADDPDDGDGEGYGEVEIRVKNEVNKKYPLTYISNFAKAAPLSDKVLLELSDNSPMRLCFRIRNEGGGSLAFLLAYKVDDEDEEDGDEEGLDGDDI
The following text describes a protein:
Function:
Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (By similarity). In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation. Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells. Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression. Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the nucleus in the presence of BMP4.
Sequence:
MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIYLKNMITQYWPDREATPGDIAPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWVEILKTVVNRDVPNETLQVEEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVSHALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYKDQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKVLTGVAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYNPHLLLNTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLCALIDMEQIPQVLNQVSGQILPAFILLFNGLKRAYACHAEHENDSDDDEDAEDDDETEELGSDEDDIDEDGQEYLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQIFKAIFQTIQNRNPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFSAPVVPSSFNFGGPAPGMN
The following text describes a protein:
Function:
May play a role in the regulation of membrane traffic through the trans-Golgi network.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MNGSRSSRALLKYINKATDPFNLEPNLALNLEIADYINEKQGNLPREAALLLLKRLNLGNPTVAYLSLNLLDILVKNCGYPFHLQLASEDFLKRFLQCFPVHPPLRLNKIHKKILEMLEEWNILLCKNSRHRADFTRIHDMRELMAYRGYKFPKVDKDAINVMIPKSTLRSAQELAKEDRIAHEAKLQELLRRGTPMDLAEANALMKIIAGYEKDDTEDYYATASADIENITKKTHLVQRMLSGEHVGEESLEEAIDSLKACQTTVNRLLQEESEDEYYVSKLLELNDLIHSVLGQCNEQNVHGQPSEKMDAAVDSATSNIQSLSLIDFGDEPTQASPSAGASALSSENSSSTPNPVSNAFSLDKVEQKETSNSSSVFDLLQDPAFIPSVPAATATTASSIAQPSVSICKTDSLSLEVFALNSSNVDDSLTVRFKAVFSNNNTNPVSKINLQIAVVKSLHLELHPIQGAPELAPESKDALSEIFDVSKVPVSSESVKIRWRLSWLCGPTPCSSTGESVLPFTHTP
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.
Subcellular Localization:
Nucleus.
Sequence:
MKQVELQQRERERERERERMGVPSFFRWLGNKYPKAVVKAIVDQRDESTSSPNPNGMEFDNLYLDMNGIIHPCFHPESDEDGVQPTSFEEVFINIFEYIDTLFNIVRPRKLLYMAIDGVAPRAKMNQQRARRFKSAKDKELADAEEEKLRRQFELEGKQVLQKKENEVSDSNIITPGTDFMYKLSNALGSYISLRLSNDSGWRHIKVILSDANVPGEGEHKIMSFIRQQRNFPSYDPNTRHCLYGLDADLIMLALATHEVHFSILREDVLNQEQQHANCQSVREMTPSSVKSGNRKASIVKKPYQLLHVWILREYLELDMQINDPPENFKFDLERIIDDFIFMCFFAGNDFLPHMPTLEIHENAIDLLMTIYKKEFKNLGGYMVDMLRQVNDKKSGYIKLSRVEKFILLVGAYEDKIFKKRSELRERKLRRLCLNKDSLEEEIDAGSSATDSSSTCALPNGEESEALSLGMFENMHSQIIENTKEFKQKLKDSIRRKSDLFKNGDLGTDKVRYAAAGYKERYYKYKFSAEGPGDIESKRKEVVKYYTEGLLWVLLYYFSGPPSWTWFYPFHYAPFASDLKGLGQVKSKFEKGSPFLPIDTLMAVLPPRSAHALPKVYQTLMTDESSTIIDFYPSDFEIDMDGKRFTWQGICKLPFIEEERLLSETRKLEKELVGEDRDRNKEKVDQLFVLSTDNMASQIVALFTKENCPIKIDNSLCSGISGFLRLHENASSVKGGDHKLQEDSVLCVGYELPNDGPHVPRLLAGVEFPVKTITEDDLMETKLWHEYQGSTPSSSSQLVQERFRKPDNMGNQGFQNNGRFTSSSPNMIHKFSGTGWGCGRGKAIASPDFGDRFHAPGRIHCERVVSSGSYSANGAVAYKKAALHETPVCNEKWRVAGSGSGDQIRTLRDLNISKSSSSQGWRPNGRVQSANNVFWPSRNGFTPDTNHAWQHGQCRGRGHQDSSKHYSPFSANRSSQASGSAHFVPRSWDTEGKPRW