The following text describes a protein:
Function:
Ribosome collision sensor that activates a translation quality control pathway when a ribosome has stalled during translation (By similarity). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes (By similarity). Gcn1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of eif2ak4/gcn2 in response to amino acid starvation (By similarity). Interaction with eif2ak4/gcn2 on translating ribosomes stimulates eif2ak4/gcn2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/eif2s1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator atf4, and hence allowing atf4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MNEENPSSSIILDDQQQQDSFYSEIKELEKSIQSNKLSERKNTLTRINSIGKHELSTQENDATTTTTTTTVDLEEKLKVLIYLYFTSYSIGPDSQWIFSLVQSLKQLFKDISSATNTSLVTDELKINIVKFTLREIGRLAKLLPTNKRSKYVPQNTLMSFSLVLLNYFIDQIQSNSDLTTLLFAAQELLYRELTLQHMKNNQPIFNQILNKNKILTFYQNIVTKDSSNKSFFIVYFLLRNFTDQSNKQKEQDNTFKINDLLNIYNKTVIGSSQQKIEEHKFFKRLFNQLTNEDLQSIILPPLSRHIKRDQDQVFKILIFILENLSSDFNVIDLSSLLKSMLLPMLLPVIQSTISIEENRKLLKKTFTLIIERSKDTKLISSMITDDLLKTLSVAGNPSQKLIIISIISSIISTKNFIERLSLTTEKLQLSKQILQSISIYLEKELNKDNRNKGFKLLGKVMKMVEELPEQTIKIITNSLKNDDDIIKGQVILSLSKSLGPEANGTNKKVIQIINGFTETINTILKNVKNAKTCDPSTTTASLHYMLSLITTTGVPKNDIFTKYSTDKTTISNLYASTSFLHTDGFIQRTSKKDHAIDLLLTLFLRVKSFPSIKLNDKSPLYSSVLNCLLHSQWSVSKHSAIKIRSILSRNDSVDIDYPLLSNQLLIEFSTILFDDSLIITPQIINSNVESTTTTTTTISNKKNYLIAFRSILSKNIKSELYPMLSLICYHPFINYNWKRVSSLIQNDVNTTLSSNAIEISKYIFEKGLNQKKNKSYQQAFQQAINGLMNYNVPLLNEELVKLMVKALSYEPVLAITQQQWSIYHTLPTELFVEKQEQLVESRNDRKVKPKTAEEQRDEESRKRIEEKKKIQSGELEKQEKERQKQLAAQAVIRKDVQDVIDRLHLAMDTCQTMAKSSSNPQFVGEFMSPIIVALLQLMKHEITNHQFTQVFEKLICCVPSRFKLDRSFARHYIYIINNIYYRPTLSEIQILGFIQKILTHIRESIAKEALSGFAFNYFWPIIKNGLETTISFTIQEISMEIIQKHTAQGQAYPRGSMISSLIIVVSTNSRLEAQARNTIFQLIEGVETSDIGELMEGIISKHVQVRSICLQAIEKIPSIYSPSFVWEDKYIGSLWFARFDNHDANTSALAEKIWLATNQPTQLPEDFMKLLSDSTFNVNSETRKINALAIKEAATCHTHMIPEIVDNLFEIYEQNYPDEIRETPITSKFRISVATALSGLGNAIVEPEVLKSLFTKIIERGLFDPKEEVVQEFVSTGMSIINQQGVQFSGELLATFEAFLARPDNGTGEEDSIRANVVVYMGALAKHMDASNPKVSIVIDKLVDALSIPSESVQVGISKCIAQLIPSFKKQGDRLIPMLLEKLKNSSGNYADRRGAAFGLAGSVKGLGIGSLKNYSILDTLQSYIEDKKHPTSRQGALFAFECLCNTIGRVFEPYIIHILPKLLVCFGDNVSEVRDATADTAKAIMSQLSGHGVKIVLPALLKALDDRSWRTKEGSIELLGAMAFCAPKQLSSCLPTIVPKLTYVLNDTHTKVQEAAKEALSHIGSVIRNPEIQIHVPLLLQTYDDPEIHSKELLENLLSTNYVHTIDPASLSLLLPILERTLKERSSELKKMSCQIVGNLCSLTEPKDLVPYLNILMPVMKTVLLDPIPEVRAICARALGLLVRGMGEENFSTLIPWLLETVKSDQGAVERSGAAQGLSEVLASLDISRFNSLINELLAMTNSPRPHVREGILSIFIFTPISLGDLFLPYLPKVLPQVLKGLADDSDPVREVCMRCGQSIVLQFAVTGIEVIVPALEKVLFHENWRIRLSCVQLFGDLLFKLAGTTAQEVQSNNSSYNAKDDDDDEPGSSGNDIQKILGKERLGRILSSLYMMRFDNNSSVRQKVLLIWKYIVSNTPKTLREILPTLIEMIISSIGSNNVEKRQISAKTLGDIVSKLSDRILPEILPILERGLRSELEETRQGVCIGLSEVISSAKTQLLPYLSSVVTCITKALCDPLIDVREAAAKAFDHLYHTFGSKASNEILPQLIQLLDNSNNKDLAGYALDGLRQVILVRSSIVLPVLIPKLLSRPISTSNVTALSSLAADAGEGLYVHLSTIIPSLIESFTNPNTISNAKEIKEAAVSICKSIDEQGWDTLIGLLIEQTEIRLPNIRLGACELIGEFYNGNTMVTEYPEELLLSLLSLFNDPDALVQQAANNALGFITKSLKKDNLTYLPVFQKGIQLLVNETYEEVSTIPGFCLPKGLASVLPVLISGLMYGTSDQREQATNTLRTVINHTSADALKPFVMQITGPLILVIGDKFPWQVKSAILQTLSLLISKSPASMKIFLHQLQPTFIKCLSDSHKNVRTNAASALGLLMTLSSSVDQLVNSLITGISTADSISQESKLRALQSIFEKKPKVEQATLDKAIATIVDFLYQPSDDLRSMVAQTIGASSKCFTSLTELNQFIKTNLISPSQSVLSRYGKSLALGEIFKASGKNLIDSQSPNMPTIIKIIQTDCRDEKGPIRESSAYLAEAILVASPLTYAKDLVPSICHLIGDQSSSVSISALNVIKRFCKSNQQLSRQYLRDIVVPTMNRLKERTNLPLKLAAERTLVHSLQIFKESIVMDDLIKQLELSGDSSMANSLIDYHKRVLMKLSPDSDIEK