lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the homologous recombination repair of DNA double strand breaks, thereby playing a role in chromosome integrity. Acts by targeting rad-51 to sites of DNA damage and stabilizing rad-51-DNA filaments by blocking ATP hydrolysis catalyzed by rad-51. Promotes rad-51 mediated displacement-loop (D-loop) formation during strand invasion between the invading single-stranded DNA (ssDNA) and the homologous duplex DNA. Also functions independently of rad-51 in DNA double-strand break (DSB) repair by promoting DNA single-strand annealing (SSA) when the homologous recombination (HR) and non-homologous end joining (NHEJ) pathways are compromised. Binds selectively to single-stranded (ssDNA) via its C-terminus. Involved in telomere maintenance and replicative senescence.
Subcellular Localization:
Nucleus. Chromosome. Note=Diffusely localized in the nucleus. Recruited to sites of DNA damage upon induction of DNA double strand breaks by ionizing radiation (IR) or in meiosis.
Domain:
The BRCA2 repeat-like region is required for rad-51 binding.
Sequence:
MGDSSKKVKDSFDTISEPDSFDEPKGVPISMEPVFSTAAGIRIDVKQESIDKSKKMLNSDLKSKSSSKGGFSSPLVRKNNGSSAFVSPFRREGTSSTTTKRPASGGFEDFEAPPAKKSTSSSSKKSKKHSKKEKKKEFKEIHADVLRVSRIYEKDKFRIILQESSSTPLILATCSYNRGSDIKFGDRIHVDAEVCKKSSSGDVTEIYIDRVLKNKENGAKSGIRRHSIAKKPFCIKPRFIHELSDTKIKKTVVQVNLLDLNLDFYAGCSKCKHSLPEAANQCEFCKDSQGKSELSMYSRVRVMDFSGQMFINVTTKNMKKLLDLLGYEGFDNWFRFKDPQERQNYVFRPVMVEIEKSNDEWECTDVAEVDWKDFGSYLKHKEDKKKRRSKKKHP
The following text describes a protein:
Function:
Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MASYFLPSFLTGWDLSSVSAFSLSANLQKRILSYLLKRTLGHLVDGGQLDLEQIDAGIGSGRIEVRNVQLDAQAISRHLPSLPITFVAGQIGSILIQLPVPYFWNGELSINVSDISIHAKPRSDNPEHTSSPQQDLSASFASAASQLFVEDEEAKDLEQSIHESLYPENQKQAQQRTEEEKGSLIATYVEALLTRLKVSIEHVQIHLQSDALDLSLKLSYASMKSSNTRSEQQADASVSDSDQTCGTDSAAVPHRRLLSETKRTLEMQSLELWLQDNRKPSDSINAVSPSSTDGSMDHLVSQPYKPSHEMSQSVASLQASSASLYESAIGESAFPESLEKPNQDPLHGDDISSTAPPPLSGRHLLFSLGQEAVLVTLKTTKERHEFLVSDTASRRVEQKLISIVTDVDVQIGNAGGIIFIDHLSLLMSLLQSFDLTSRHTQQESTLKGPKAQPMRTLSSAQTGGDFTLSCHIDSFNLIIGYDDPHVLQQDQSSLGAFWARPSRAHPDFGHLRLRCNKLAAHYNHAQTGLSPAQSHAQIHFSVDDLGLFEQLPTVLYQQCPPESSRVLPILILDPTLSQSGTDSPARAEHLQHDYASSTVDVSDWRYSPSHQTTGPRSHATPDAQNAAKGARFKSTSIRPGSSSSVPSSPLRTAYSDQGWKIKAPIKSQTQATAPEASLPCFVVSISLPQSCKDQGQVTATVAPVHLFVDISLVTRLMPGLRRFATAQIAALQGVSEPDYELTDSIATLGASVATIQTSTDSLLGHHSTNQAAAEPNPYKLDLQISFVRVDVRTPQVSYDASALGGRSLSSVRLAGLDRRSGILVLQVQHLHLHLGLSETHQTASAVRFASPSTSADGRHNRGPVVTGVINAEKISAFLALPSQSRALVLALIEAIHDDAEVSTPFASSQNALLPRVELSQITETAPGRGQFDPRHGQAKDRCSILIPSIKVELEKTQLDSLQYMADDLTQSVNLWTSDDPDESDSHDAEGLKILGSRFFGSRAGMSIMSTSTDSTATARTSTKNSSLLLTITESSIRLWLPSLSPNTESVGDRRTRSAKSLLLTTTDFELLFDSDKARNTNRIEIRIPDMQLSVEAGSAFAETSSTLLAFRTMERTLNDQSRNMMLLLVLEAYAEPGTSYREQNIDLTLCSVTLAPSFDQELVPRIKRLLKAPAGVFENVEPNEVTRVSFKAKDCSVFVAPQGTQHRAAVAIGEASVKTKLTSHAPKTSIKLAIAGLDVFAIEAESSQSSSRRRAADKSASDHWSKRGYARLLHAPESKVSIHLNTLTRPEVDVKVTKLRVKLQATADTLNVVTGLVGAITETQAAGSTESRSASPLPHDSFMSSTDSEYSNRSNLSEKEVGPIQTSKTADHFDRMAELLSGIEDDAYHLASPLPVAADLVEDDVPSDAAFLGSKGRYHPDIVETTLDSDEFFGGESVASLSLLAPRADTVIFADEDVTVRLLDPKGICPVQEYFTDPGLRPHVNSALGTAASSVRVRVSNFDLSVRLHSGYDWPSTRNAVQQEVKLVRKRLQKIKQLLAEGQVPDDSVEAATSNLLDSMHISLPNVAAEMDADEMMRAVEDEVGDCSDAASTTDSDASASWQALPFVRRDRQASRLDHRRAEASHTKLERSAGSLIDFNLRGLEVEFDKADASLAGNVVSRIAVNARRFEIIDNIKTSTWRTFLTEMQDANSALRHDVESKMVKVEIVYVRPQGLEPEGASVEQPEVRMRARLAPLRLHVDQDALDFLKKFFMFKPPGQKETSGAAAATSGSALPFVQFAEVLPIKIKLDYKPKRVDYNLLRQGKTIELMNFFHFEGSEMVLRHVTLRGINGWARLFDTLNDIWTPDVKANQLADFLSGLGPIRSLVNVGAGLADLVLLPIEQYHKDGRVLRGVQRGAAGFAKTTALEAVKLGARLATGTQVILEQAEHILGGERMEESITASAIGPESGQSFQSLSESVMVERMSRSGSVSRYAQQPLDMRDALAQAYSGLTDHLTSAAQTILAIPMDVFDASDLAGAPTTRSSEHTRSRPVVKAVPIAILRGAQGASHAIAKTMQGVQVALGDRQNVDEQKYKLPPHT
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.
Sequence:
MRLVMKFGGTSVGSADAIRRVTEIVGTYARDHEVVVVVSAMNAPDLRTTDTLIAAAKAAAAGNGDATAQIAPRLLDLHMRTAAEVASPAECAALEPQIRSMLDYMSNLSRSIAVLGELTPRALDLFSGLGERLNARLIAAALRSAGIDAEAIDATELIVTDDRYGNASPIEPDTRERSRARLLPMLADRKVPVVTGFIGATRAGVPTTLGRGGSDYTCAILGADLDADEVWFWKEVDGVLSANPKVVPEARTLPRLSYAEMGEMAYYGANVLHPKTVQPLVHRRIPIRIRNTFNPSHPGTLIDAEGDGESVRAITAIRGLSLITVGGPGMLGLTGVAARIFGAVARVGANILLISQASSEQSVCFAVPGDESERVVEELRRELAREFAAHDVDHIGTIAPVVIVAVVGSGMRGTPGIAGRVFGALGAARVNVIAIAQGSTENNISLVVAEADADAAVRAVHAAFVG
The following text describes a protein:
Function:
Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes.
Subcellular Localization:
Chromosome. Nucleus. Note=Localizes specifically to X chromosomes in hermaphrodite (XX) embryos after the 40-cell stage.
Sequence:
MSDEPPIVLPTEEDGPFSNCVSIAFVNDKSIPVELRIRKAIRGKVTFTQELVVAARRLYLDGELERPDLNYHVAADFYDPFMIPVPDHRNWEYNPLYPREWPRLIDRDLVQKIKMSNTYKKNQARRKRRRLLRIFHRKRGGEFLNYLWHSKENDVHYKRYMAAYQFPLPFEKCIRDVVREELKDPETSFSKPPSVVHHSKIRPATPDLLKLAKYLGKDRFCFIVTPFKFRSQFRLRYYKKSPFKRSNILEKWLKFKKVRDQGVFNIRDAAREVKKLLQRKNVYHMTDPQCEQEFWDVYRLQMQWLEEDNIEENITMLRENLSKVTDEEFNRSVYIMRPENRASIHDDVTFTTDAEINLKPIVLELFRNNMPLEDIRQVKECIDDMINLTVCQELIPQVATIETVRDYSGVEQHRLKYIRPENELEIMFQLATVLVKNENTHDQEITSPMFALLRTEQYLWSIPLRPFLRMYTDWRKTKLNFKKFRKFSPELVSKAPIDLFKVFLTTNMDKKGVATKDTDCFDYRTASEIKKLYHEEFIRVRPIIEHQRFHRCYTSVITEEPLPNPFYWVHRGQWEKVYECNWKQRVKPLAGRFSWKTKHPNICDLPRLEKDDKQEMEMLAKMREKIREYNKEKEKHPFYVSSSLPEFASTSDFVKFPISNTGIKYTAPRRNQPKVQRSLVTYTRFRLAELEDKDFSFPEEKMLEKNRLLEKLNFEERLQLDALMSKDVKYKPRMIPEKGFLQLQDEKLILKRLCEKEDEWSGKQKRRFPDLYEQATQEAERLGDPDASTSGTSNKELGLLPVWKHDDFRDLKKINVLGSKEYPISSPYLIKRLHYDIHLEIVRDKLKSWIYRTELWEKMKPVYERLKRDKEKREKEWHEMRAAQRAQKEKEEEDQRRMDMGIEHGQESLLKSITPEVEQQILLPISRENSFEEMLPAPQEAYDEDLDQDIDIHFDGAESVCTGIRLDSEDRELVDSPDQVENEEPERVEAVTENIRQEMSDAEMRDLMRKKREQYSMLFPNVPQPFQPLNRFDVTAPGAGIVPPYDEAPDFDLSAYLEEDHVRIPTLSTVEINSLLKDQDLVEEQEIVEEEETPLVVEEPDIPAAPVLSAEEKASRISREMSALRKLPDAAFNYASDRDGVVVEEVETIEEIQEIYNDKLEKMIAARLGSIAQGANIERLSEDQLLGDQGSEDISFEEIQVDLLLESGVEVQVNQSVTISRSSTSFESLLVEDPEEHPEQLPVSASEKANNQIVPEVEVEGSVVPVTNQQEENVTSEGPTLQEGSSIPSSSHIYTVDELLGTESPGPEATETPVAEESPKKKSGKTTRGRPKKVKENLKKRIQPRRGQKEEAAHEPEVVEEQEQVEPEVGPEVVHEPVPAPAAQLETEPIEQQIEEPDKVFEPIIEALPLFETSPVPAPEGNIPSRAHSSDDDVQVISSETDPNGPINLVEQVQNDKLTAYQYSTEELLGEYGELDEAGAPSPSEIVVHDEVLQDEVLQPNPKSSKKRGRRRKKTPPHIAKARKVFTSISKTEEIELAPTPTQQSRKRMANVSSEEATATRRQKRAKVEEPNDSDVSRVLTPEPEDLHETERPGHVGEEGFETPSLRTGRESTASSVKTSRSKRLFLSKNNPVPRMRIQSQAGTNASPTPARRTGVARDSVSPDGASEKLKQLPKSVQDIFEVFDVERSAERGESATVTNLEGPVKIEIEDENWMAPPAITETSRKSKKRLRAEKQQQILDDIKLELNGEPPQKRECEILMERVQVKIEEGVENADCRIVQANFNCKSVEEHETLPLKIIRVFEENEKPVHKFFMTQIIWKEINEAFMTDPEKFMLLVRILFSDRNISGQIYKISMTVTDRIKGFDDDFIKLLTQFPKKLSQEHKPLVDYNKLAHALREKASLHLNNHKITPFTFHGVISNITEMKEKIIGRCEIGMLTDGDRDVLNSTENMLLGAYMKSVLRMTAQSQVSWAHPEYIKRRLEMIYYGWRMFLGSGGFFRVALAINRKDVKPMSQQFRDFFIEYLKDVNENYAKAVELVQMDEDKLMEAMIEKAGLSSIDLLALDEDVQGQVSESHKHKCVQCSIRNQSVYFSSYSLLELHGKLHQNLHELAPEDADDCQDCYETLTSSFEVIVHRINHHHSRRCFFADD
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERDFLGLNSKESVALVKEEIKDAGKNAAFMRGPGMQWPFSNKVSALPHFMPFKAGQDDRAKKIIFDPFASGFIPTIATADAFDANKQTSGIAQKSFNFDRQGGTHYAMAAYPLQHVDAHATNHPPDVRMFPANQTISIAMNNLFIKTQNTTMGQNMAAATMKQQPLGGIPVATAHSILPTAGSMARTFDPWNISKPAGAPAQLTIFYAGAVNVYNDITPEKAQAIMFFAGNGSPMTNPIAQVQTPTAKPVAGDGLLGNQLHPTSPCSGLSSPISVNSHASVQSGSGSSSTDDLASRQIGNMNASSCHQEPQNRVASMGSAAPTLMPAAVPQARKASLARFLEKRKERMMNMNPYNLKKKLPEGPISSGSNGLGFSGDSGPVSVDLPVSKKQAWCLGPNKNEAINNNLQVTLEM
The following text describes a protein:
Function:
Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity).
Subcellular Localization:
Nucleus. Note=Interaction with PIAS1 is required for localization to the nuclear periphery (By similarity).
Sequence:
MTSLPLGVKVEDSAFGKPAGGGSGQSPSSAAATAAAVGADEEGAKPKVSPSLLPFSVEALMADHRKPGAKESSLAASESAQAAGGLAQPLGVPPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKPERTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYGASGPFQRAALPVAPVGLYTAHVGYSMYHLT
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Subcellular Localization:
Nucleus.
Sequence:
MLRFPTCFPSFRVVGEKQLPQEIIFLAWSPKRDLIALANTTGEVLLHRLASFHRVWSFPPNESTGKEVTCLAWRPDGKLLAFALADTKKIILCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYNSTSKIFSEENSDEIIKLLGDVRLNILVLGGSSGFIELYAYGMFKIARVTGIAGTCIALCLSSDLKSLSVVTEVSSGGESEVSYFQLETNLLYSFLAEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKTTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLLYHLSELKGMASWKQKYEPLGLDASSIEDAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSNHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKPADVIGRSMNQAICIPLYKDARSMDGARRLLKFPFLWNNKTSNLHYLLFTILEDSVYKMCILRRHTDSSQSVSNGLIGIKFGSFTYATTDKVRRSTYSCLDAQFYDDETVTVILKDSMGREGRDRILVQLPLSLVYNSEDSDEYEFTGTCSTRLDEQGSIIPTRTMHFEKHWRLLESMKAQYVAGNGLRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDDDEEAAGKPVKIKEEVLSESETEAHQDAAALDSDVVIKVEKLDPELDS
The following text describes a protein:
Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane. Mitochondrion matrix.
Sequence:
MAERTYDDAINALNTLQTPYEVLKKRWEAGIKLDEGQDDLRRLNVVHVAGTKGKGSTCAYVDSALNSYRTSHGFPKKVGLFTSPHLIAVRERIRINSAPVSAPLFAKYFFEVWDRLEAAAASSSEPFEKPVYFRYLTLMSYHVFLQEGVDAAIYEVGVGGEYDSTNIVDQPAVTGITSLGIDHVFTLGETLDKIAWHKAGIQKAGVPSFTVQQKPEAMKVLENRAREKRVESFKIVDLDPRLIQVKITPEADFQRGNASLAICLAETVLKKLNPELDTWEHFLPISVVEALERVVWRGRCETKVDGNITWYLDGAHTADSIVVAAKWFSDKVAEKNGPRVLIFNQQGHREAIGLLEGLHSATKESIKFDHVIFCTTSIQKENASKTGNSASPTPTEHLLIPPDFVNLSYDPKSISELTMQKAFAEKWRSLDSNPDTDVQVLPSVDDALEYVRSLSTDDAHPQALITGSLHLVGRALGNLEKRDAL
The following text describes a protein:
Function:
Involved in pre-rRNA processing.
Subcellular Localization:
Nucleus.
Sequence:
MSRLIVRGLPSYLTDARLREHFSQKGAVTDVKLMRRPDGTSRKFGFVGYRSEQEAQQALDYFNRTFIDTSRISIELAKKIGDEELVHQREERRNRRNAGAGPEGSASTSDARKRKADKSDTQQEEGSGKKKPKKGGAISFEEFMSVMQPKAKRKAWQNEDALPEQTMQDIVAPEEAIQKKAARKALKKADAAAAATATAESTAAQPDSGREETPEPDAAANDVGLTDEEYMRLRMKHRVGTDLDTLEQSSSGPEFEQSDNEKDDDDAAADSDPESEDEPIHDQGFECKQAEMQRKAQQAAEKDQKLVDQIMESGRLFIRNLPFAASGDEILAFFESFGTVKQVHIPLDKQTKASKGLAFVSFSDPAHALAAYRAKDGSTFQGRLLHLLPAVNKDALAETGSKKTATLKQARAEQKKQDATKDFNWSMLYMSSDAVASSIADRLGVNKSDILNPGANGGADNAAVRLALAETRIIQETKEFLAQQGINVDAFQGAKGPRSDTTILVKNIPYGTSAEEVEKLFGEHGEVDKVLIPPSGTIAVVEMPVVNEARLAFRAIAYKRFKGGILYLEKAPVGLLTQHKVGEKVVKQAPIVGKSIDSSNPSVDLDGPAGAGAGDEAVDGATLYVKNLSFSTTDERLTAFFHGLSDFAFARIQTKPDPRRPGARLSMGYGFVGFKSIDAARTAQKAMDGKVLDAHTLVVTFARRNAEASTTSISSGGSTKILIKNLPFEATKRDIRDLFSSQGQLKSVRLPKKFDNTTRGFGFVEYSTVREAQSAMEALKHTHLLGRHLVLQWSHLASSTQQQVDMQRSKTKQHFVNTHDNAARADPSKRAKIKLNSAQISEAIKQAKRQRDDVDDDE
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDWSELNKEQWAEEGRAVDDLKDAWDDEEEVEEVEEEKVEEKKPEKPAVKQLTKKEALKKAIELKEKEEKESRNNPASEFDIYMEEKRRKELQEAADLENSRTLFSGVSVRETTPSEPIGSFVPKTEKEFEKYADIVSDYLTKYDSSIHYASFFKHLIKKSLANVPSNELNDISKALTVVINEKIKNEKAGKGKKTTKATAKKSLQMGSELENYDDFDDFM
The following text describes a protein:
Function:
Involved in endocytosis.
Miscellaneous:
MISCELLANEOUS: Present with 1640 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasmic granule. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPNSNVRIPPTVPSKIIDVVDQALRARLLGGSTFNSGFDSLDSVLNLQFRLHYHVIGSNGPAKPVCDVLLKESQNLEKNMSMMEELNDYPEITKLVEKILFNCLGILFFHRGQFQESQRCLLHSLKIHNNTASQKTALMEQYDRYLIVENLYYRGLVSQDINIMQNVFYKELLAHVDTIPPESNGLLFEYISLIVAKLRFNQIQDLAENFKTTVENPFILFLYMIKKFQSPLKKHIDNDDLYLKFGQNVLLKAKFPTASETNDEALEHFNVFLQYYFKFTHIKKIKVNPSWYNFIISSMEKTFQSIEVSKTAMFLFQNLSDNSNDEIKKKTFKRESILNFVNFVKYNDKYYQLHDNSHRDIISFIDAYSFILQNSSKTDSIENVFDYDNTVSTFATSLNSFYKEYNLPLMSQSESLDWLENSTRCVYPGNISKVLTNAWSTLYEIRKYQLDFLVSNNLTSYLCNAMMLSTKEKDNADVEEQEEGEEEKALRELQFKYSYTLAQQRHIETAIKTLESLILSKNPNYYKAWHLLALCRSVQEDKEMSYKIVCSVLEAMNESLQNNTLLLNDRWQFIHLKLTQLALIEEIFGTLEALETLPEVFELYATLFPDSQPELNSMGPKYSQTKEYLLQMVWIFAANMYMRTKDNDEDAKAAIKEASNVESKFKNLNCNIANGYLSIIKDEPGVALKEFETVLYYDENNLDALVGFAELIFPEELGVEETNLERYYTLSLDKKPGKRAKLTFVNDTDRSAAYARLKFLLECAILESIEAYYSPEVWWYLSLIYEKYQDDEYKNSLLKCIKYQELNPIRSLRYCNY
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MCDKYFYNKIQLMLTDQSVITKRIQSVHFGYYTAKEIREMSVKEISNPKAFDKLNHPIRGGLYDPALGVQPHERGTRCVTCGQENMDCTGHVGHIELLLPVYNPYLVNQLMSLMRSKCYYCHKLRITKDRKKFYKNNFKLLRLGRLIEMKKYQKLYMTKLRLNKQTKNAENRKQSITATDTSRKGSDHRKGSDNKMQCDQETAPQEFLDIEDVKQQIQEILDILQVKKHQSEYIDGIHQTSHILQELKILTKQFFKDINKKCPHCNKVSPNVRKEGVMKKEARILKRTNNNKDRIRRKIITQIQWKFQSIYINYGVGIKIYQNIYMVAFMLMLTHQKMLKKDMSQKRFLQKIFSSKYQLFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNLNGHTVTYTRILEFNQELKVLITNMTNAPAQTQSSMEALKQSDHMKNNLKKIIRLDTIMQKWLELQDCVVGLVNSERAQNKQNRETPGVKQLLERKQGLFRMKMMGKRVNFACRSVISPDPLLSTNEVGVPTVLARKLIIPENVNSLNQQYVADLIMNGPVYPGALYFQEDGKKIALEYLTPQQRMAIVRELGSGENKVVWRHLRTGDVMLFNRQPSLHKPSIMGHIVRVLPNEQTIRFHYANCKSYNADFDGDEMNLHFIQSMIGRAEGYNIALNDYQYISQTNGKPLRELMQDMIVSSVFLTLRDTFLTKQQYMQLIYTAIWSLFEKNSQKIELLQPAILKPKQLWTGKQLISNIIKIIVGLNGYDPDIGLNLESKCKLSSKELPGMASDDIQVLIKDNELLLGIVDKNQVGSGADYGMMHAFHELYGPKMTGQLLTGFARLFAAYLQYHGFTCGMDDLIVDELHDEKRRVLIEENLKKGVRQAAEYCGYNSQIPESINLFNRSNFVFENGQYNHPKYLQDVHYLQYDHQIYEALRQKILIEKHQEEALDQEYKKAMTKVTSEIVGSTLGGLQKLFPLNLFSMMTMTGAKGSNVNHSQVSALLGQQELEGRRVPLMPTGRSLPSFLPYDPNPRAGGYVADRFLTGLRPQEFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLIVQYDLTVRDNDGSLIQLFYGEDGIDTTKTKYLEKFSFLAQNNQHYKQLYRVQEMKQHFKTLDGASVELENDTLMNAFNPSQNLGAVSMKVQSTMNEYLQKCQNELQQKKISNKQFKSLANIRYLRALMHPGEAVGCVAAQSIGEPSTQMTLNTFHLAGHGEKNVTLGIPRLREILMTATKKQKTPTMSLQFLNANIEKSQADRYAKRMSKLVFLELVNNIKVREYKRLTENGIPLHSLLRGVIYEIDVELEDLNQIKYVFGISEDQIKNKVNHVFIPLLLKIIQAELNKNSSRCVEKTSFLKTKENEAKKQRKGSDDEEEDDEDQQEEQDDLSELNQDEEVLNIINQTFEQSAQQYDIFEESHQQQESQKKQTPKKEQQQTPQTTQHKYLEKAEVQKQLIKVVIKLPLNSKKMLMTNVVKKTLSNTVINEIKGINKAKIIKNDKSGGASFMIYTEGVNLNKIRNFDFINLNNIDCNDIVAIMNAFGIEAARNAIIKEILAVFGAYGVAVDYRHLYLIADYMTFGGQIRAMNRIYMDFNTAPFGKMTFETSTQFLTNACLNRETDTFNNLSSQLVIGRVPKVGSNLCDVLYQFETEE
The following text describes a protein:
Function:
Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRTKRWPDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAVELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMADAEKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRFSTVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHRSFRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MDKRIENTKSKINSPEFQSFNKVKKKRIRRQLKKLEITKKRFEKIKQRANKSRENNENESENESENESENESENLDEEEEENENESESETKDVENVNGKQKENEKEKQKENENENKFDTLIKNNNNDIMSKYYSQRYRLFSKFDEGIVLDQESWFSVTPELIAQHIAERCSCNTLVDLFCGAGGNTIQFSFTCNVVVSVDLDPMKLLMAKHNSWVYGHSSENTNIEFVNSDAMNLSNLKADVIFLSPPWGGPNYTDSSIFHLDSMTPNGFEIFKNAIKVTPNVVYFLPKNTSKVDIAKLALISKENGGSELCEIEENYINEKLKTITLYFGSLVNNNNKNYESYQ
The following text describes a protein:
Function:
Constitutes the pattern-recognition receptor (PPR) that determines the specific perception of flagellin (flg22), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Recognizes flg22 from Pseudomonas aeruginosa and Acidovorax avenae. flg22 is a peptide derived from the bacterial flagellin N-terminus sequence. Does not recognize flg22 from Xanthomonas oryzae pv. oryzae (Xoo) or Xanthomonas oryzae pv. oryzicola (Xoc).
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MERNKFASKMSQHYTKTICIAVVLVAVLFSLSSAAAAGSGAAVSVQLEALLEFKNGVADDPLGVLAGWRVGKSGDGAVRGGALPRHCNWTGVACDGAGQVTSIQLPESKLRGALSPFLGNISTLQVIDLTSNAFAGGIPPQLGRLGELEQLVVSSNYFAGGIPSSLCNCSAMWALALNVNNLTGAIPSCIGDLSNLEIFEAYLNNLDGELPPSMAKLKGIMVVDLSCNQLSGSIPPEIGDLSNLQILQLYENRFSGHIPRELGRCKNLTLLNIFSNGFTGEIPGELGELTNLEVMRLYKNALTSEIPRSLRRCVSLLNLDLSMNQLAGPIPPELGELPSLQRLSLHANRLAGTVPASLTNLVNLTILELSENHLSGPLPASIGSLRNLRRLIVQNNSLSGQIPASISNCTQLANASMSFNLFSGPLPAGLGRLQSLMFLSLGQNSLAGDIPDDLFDCGQLQKLDLSENSFTGGLSRLVGQLGNLTVLQLQGNALSGEIPEEIGNMTKLISLKLGRNRFAGHVPASISNMSSLQLLDLGHNRLDGVFPAEVFELRQLTILGAGSNRFAGPIPDAVANLRSLSFLDLSSNMLNGTVPAALGRLDQLLTLDLSHNRLAGAIPGAVIASMSNVQMYLNLSNNAFTGAIPAEIGGLVMVQTIDLSNNQLSGGVPATLAGCKNLYSLDLSGNSLTGELPANLFPQLDLLTTLNISGNDLDGEIPADIAALKHIQTLDVSRNAFAGAIPPALANLTALRSLNLSSNTFEGPVPDGGVFRNLTMSSLQGNAGLCGGKLLAPCHGHAAGKKRVFSRTGLVILVVLIALSTLLLLMVATILLVSYRRYRRKRRAADIAGDSPEAAVVVPELRRFSYGQLAAATNSFDQGNVIGSSNLSTVYKGVLAGDADGGMVVAVKRLNLEQFPSKSDKCFLTELATLSRLRHKNLARVVGYAWEAGKIKALVLDYMVNGDLDGAIHGGAAAPPPAPSRWTVRERLRVCVSVAHGLVYLHSGYDFPVVHCDVKPSNVLLDGDWEARVSDFGTARMLGVHLPAAANAAAQSTATSSAFRGTVGYMAPEFAYMRTVSTKVDVFSFGVLAMELFTGRRPTGTIEEDGVPLTLQQLVDNAVSRGLDGVHAVLDPRMKVATEADLSTAADVLAVALSCAAFEPADRPDMGAVLSSLLKMSKLVGED
The following text describes a protein:
Function:
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Sequence:
MRHFWLLPAVAGIAGAQCPYLSGEMSFTQEQDNAGDTIEVTEQPIDNTLYVNDTGSYMTTDFGTPISDQTSLKAGPRGPTLLEDFIFRQKLQRFDHERVPERVVHARGAGAYGTFKSYADWSNVTAADFLSANDKETPMFCRFSTVVGFRGSVDTARDVHGHACQFYTDEGNYDIVGINFAPFFIQDAIQFPDLVHAIKPMPNNEIPQAATAHTSAWDFFSQQSTALHSALWLMSGNGIPRSFRHMNGYGVHSFRFVAANGTSKVVRYRWKSQQGVASLVWDEAQAAAGKNSDYHRQDLYNAIANGHYPKYELQAQIMDEADMLRFGFDLLDPTKLVPEEVVPYTPLGMMELNANPTNYFAEVEQAGFQPGHVVPGIDFTDDPLLQGRLFSYLDTQLTRHGGPNFEQIPVNRPRKPVHNNNRDGFGQQQIPTNNWAYTPNSMSNGYPMQANQTQGHGFFTAPYRYASGHLVRQTSPTFNDHWSQPAMFWNSLIPAEQQMVVNAIVFQNSKVNSPHVRKNVVNQLNMVNNNLAVRVARGLGLDEPSPNPTYYTSNKTSNVGTFGKPLLSIEGLQVGFLASNSHPESIKQGQAMAAQFSAAGVDLNIVSEAYADGVNTTYALSDAIDFDALIIADGVQSLFASPALANQMNSTATSTLYPPARPFQILVDSFRYGKPVAAVGSGSVALKNAGIDSSRSGVYTGSSETTEKIAKEVLEGLYTFRFVDRFALDE