lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MNMEGETASNISQSGKEQSLTDIGYTLEELQTLLNSRRTSFSHRVDEVWPNLFLGDLATANNRYELWKMGITHILNAAHGNRFCEGSSDFYSASISYYGVPAYDVPDFDMSQYFNSASQFIHRALNTSGARLLVHCIVGISRSATLVLAYLMIHHQMTLTQAIQKVQENRWVSPNHGFLRQLLKLDGELRKSRNIQR
The following text describes a protein:
Function:
Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent (By similarity). May play a role in neurulation and neurite extension (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein. Note=At low Zn(2+) extracellular concentration, is redistributed from the perinuclear space to the cytoplasm and plasma membrane.
Sequence:
MFKWKKSLFWRIPVFFTFGALFVCAESRHKDNKQPPSQGGLLQALYSLNSANGTFLHKNNSTDIISLLLEKVECPKNVHGKQDPCTQCLRPDALLFMVGINKSSDIDDDAIQKISVVLLFYIMNQKDFCTSISNLTKMDYKFYRNSLLKLRKDEDCHYLSLNEIDDILSVSKQYFQLLEEKQCTDVISMEDAFAMVGSTAVDEIKLPRLAEIILTLSLQRVCITRKQFPNAEFFTDFIFQSFNRTNDLYAPDIAELIGELKATGDCSKLSNRRKSVRSVIPQKDNELLSNTNEEKGHDHSDIYEVEAHSRYWHQTHSCFSVYELVKVFFKNSHSPVSKEQFKQISPAIIHQLLTCSCPPASNGTTRLAPPTTLEKYGYSTISVLLLTIGSMFGATLIIFSSCEENYKLILQLFVGLAVGTLSGDALLHLIPQVLGVHEVVTHEHHMQQGDYIFEENEYLWKIMGMIGGIYGFFLINKLFFLLVSSPKQGLSLMNGHLTHSHDLPLDAHLGDQSRKAKSSSTIQLRSPDDCEHSEVPETLPVRPKARRKSKGISLLAIMILVGDSLHNFADGMVIGSAFSSSTETGIASTVAILCHEIPHEMGDFAVLLNTGLSAKIAFLMNFISALTAFAGLYIGLSLSANPDVQIWIFAVTAGMFLYLSLVEMLPEMIHVQTQRPWLMFFLQNLGLLLGWLCLLLLAIYEHKIQF
The following text describes a protein:
Function:
Required for neurogenesis in the neural plate and retina. Cooperates with cell cycle inhibitor cdknx/p27(xic1) to enhance neurogenesis and increase the levels of the neuronal determination factor neurog2/X-ngngr-1.
Subcellular Localization:
Cell membrane. Nucleus. Note=Nuclear localization is essential for its function in neurogenesis.
Sequence:
MIKLHRQSYKNLQNISTASPSRVCKSARGKTSTAQKSHVNKGALSCDVHPHQAQELVSQQVELLHVLHRNDEMWRLAVQDTTKHIQSAEKKASRFSRRKQTAPPKTKSLRTPPACSTDKQNAPTVPASPSSYETLGCREQRPENPKDEATLPLTAHNIPKKAPSLLEKIGLKLKRTVEYIGASNCAFEDD
The following text describes a protein:
Function:
Inhibits voltage-gated potassium channels (IC(50)=405.0 nM for rKCNA1/Kv1.1, IC(50)=0.03 nM for rKCNA2/Kv1.2, IC(50)=1.31 nM for rKCNA6/Kv1.6, IC(50)=74.11 nM for hKCNA3/Kv1.3, and IC(50)=247.69 nM for insect Shaker IR). Binds the Shaker IR channels in a voltage-independent manner.
Miscellaneous:
MISCELLANEOUS: No cytolytic activity on erythrocytes detected. Not active on rKv1.4/KCNA4 and rKv1.5/KCNA5 channels.
Subcellular Localization:
Secreted. Nematocyst.
Sequence:
ACIDRFPTGTCKHVKKGGSCKNSQKYRINCAKTCGLCH
The following text describes a protein:
Function:
Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation; Also has diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Sequence:
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Nucleus.
Sequence:
MELQLDLSLSTTHNPIDGSNLNNKGFDPHDQILGLKPWSHDGCLLDKKRSFEDAFGKFKDSPQALSLLLWSGHPNDEDDEKREKKRLSCRLSKMNEEVMEGDDLVVGWPPIKSWRKKVLRQQPSGGRIVNNRVAGGGGSDLINSKYVKVKMEGVAIARKIDLKLFHSYQTLTRSLITMFGKCQQLEKDNANYRLAYQDKDGDWLLAGDIPWQSFIESVHRLELLRNGVMRILNFSFIVVWVFQVVTAQPTTDPNEVAALSKMIDYWNLRGKLNITTDPCAQNATWANENANPRVACDCLGNTCHITHLKIYALDIAGEIPSDLFVLKELMDLNLGQNVLNGSIPPGIGHLSKMQYLSLGINNLSGPVPPELGNLTKLLSLSFSSNNFFGRLPITLGNLTSLEQLYIDSSGVSGQIPQEFANLKSLQILWASDNLFNGKLPDFFGTLTKLRVLRLQGTSLQGPIPSSFSALNNLEDLRIGDLSGEDSSLEFLKNQTNLSILILRNCLLSGQIPEQLGTFSKLKLLDLSFNKLTGHIPTSFQDLASLQYMYLGNNNLSGGLPANIIGPQLNAIDVSFNPLSGNLPQNFAKVGSSMIIVGTSINANGLQDSKVSGMLQCLKADLKCSNKFPSSSFSIKCGGTGQTSASGIEYDDDSETLGAASQRASSDNLWAVSNVGNFISNPAPEFIAQTDSQITETLESELYKTARISPSSLRYYGLGLENGRYSVELHFAEIVMDDVSQSWKGLGRRLFDVYIQGKRVLQDFNIQKEAGGSKRAMIKTFEANVTNTIMDIHFFWAGKGTCCIPFQSTFGPLVSAIHVSQVSDGTESSKRDKKQAGKLVGIAVGCAAGLVIISSLFYLWWTKDSPKHILIQRESPGK
The following text describes a protein:
Function:
Required for maturation of 30S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTTQSERLRELLEPLVASQGLDLEEIAVDSVGRRRVLSVVVDSDTGADLDRIADVSRALSAKLDETDAMGEGEYTLEVGTPGAERSLTQHRHYVRATDRLVRFQLREGGELVARILAVDEDGLDLEVPGVKGRRPTTRRLPFGDIDKARVQVEFNRKDTKNDNQTEHDNKTEEEEA
The following text describes a protein:
Function:
Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.
Miscellaneous:
MISCELLANEOUS: Present with 56 molecules/cell in log phase SD medium.
Sequence:
MMMDILNTQQQKAAEGGRVLAPHTISSKLVKRLSSHSSHKLSRSDLKALGGSETISDGPSQLTFKDRYVFNESLYLKKLKKTALDDYYTRGIKLTNRYEEDDGDDEIIRLSNGDRIDEDLHSGVKFFSTTPYCRKMRSDSDELAWNEIATERFKWQSMLARVLKGDIVKGEKTRIANQVKKPGLNKELSDEIWLELKAWLNGRTMQEMEQSLTYLRDSSDSVFEEIMKFQIPQGKILSLDALEAILQDLMNRYHSVVSYWPNLKKMYKDKPITNTAEFTARIDVMNSWLNFKTNLTLRRQELDDWINRFSPISSSDNCQEDFDGVPQWNCKMKILAEQLMKEKNIESIFQKKIFYPLSPWMFKLKLHFIVYRETLTKMNIKYPYERLRSLLAFPVYLIKEVILTRLSYARKLKNPTMMMIDQMIDDFNAFIRLSVQLKYTLTKYCSNLPFDVDFDPTFENTVIEAIRYLFFLLNLKLIDSSKQNFKAPDLLLKYWDHLKNTGHYINGAETVIPNEFLKLTLRLVHKLQFYLLKQQNFPPTFANASEAEKWLSSIFENLGAMKRKLNRFSNILVKAFQNSAVYQINHNAQLVKKLKDAHYFLVYSGNTFESSGVYMFAAPELLGCDNDTILRILRNKSIGCDLVPKLDIGNNLNVYDITTKETDLNILVSKGEDSKGIPYYRVVANSSSDLDRHAHQSKKKNFSTDPFDQHLDEKNNEVFELEVALSSLGALVVLYPGEPVVWDGPVYKLPGNNLFASNEMDLGKIGNPNTLILLNQGSNYALTYQIDKFNQTVGDSVSFIEKRCSLNSIESSLQKINKAYYKLTYTVLNNYKGILGSFMKQCPGNELLNSIFMFGRDFGRSFLKYNAFSSKRKYVIIFLMVKLGMNWLKFLVEECDPTDQRTFRWCVLAMDFAMQMTSGYNILALNVKQFQELKERVSVCMSLLISHFDVMGARATEAENGMQQARLNIDTEENIDEEATLEINSRLRLEAIKTLEKTMKRNPRQMGKVLDATDQGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWMIQIREIAFGNSEKDQVPILSS
The following text describes a protein:
Function:
Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol.
Sequence:
WSDFFFFTPSFISPLPPSRKGNSQKELFQQISRCCSRSCVLKKQFRNDVNEPEPSGVWGWDCSAGSSLKAAAGGGGALASSFHLPPPSRSNLCLAGSSVARFQPLLQLFPSPFQDSGDRPEALVSRMVIHVYIASSSGSTAIKKKQQDVLCFLEANKIGFEEKDIAANEENRKWMRENVPEDSRPPTGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEAQAKQQA
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of scyllo-inosose (SIS) to scyllo-inositol (SI) in vitro, but is unable to dehydrogenate scyllo-inositol and myo-inositol. Is less efficient than the functional paralog IolW. Under physiological conditions, may primarily function as an NADPH-dependent oxidoreductase that reduces carbonyl group(s) in its substrates. Cannot use NADH instead of NADPH.
Sequence:
MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAAKHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKETEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFRSGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILSYDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPKPAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA
The following text describes a protein:
Function:
Putative carbamoyltransferase. No activity can be detected with allantoin or 25 other related compounds, including 20 naturally occurring amino acids, N-acetyl-L-ornithine, N-succinyl-L-ornithine, L-ornithine, oxamate, beta-alanine and putrescine.
Domain:
Contains a carbamoyl phosphate domain (CPD) and a second substrate domain (SSD), which are linked by two helices.
Sequence:
MMKTVNELIKDINSLTSHLHEKDFLLTWEQTPDELKQVLDVAAALKALRAENISTKVFNSGLGISVFRDNSTRTRFSYASALNLLGLAQQDLDEGKSQIAHGETVRETANMISFCADAIGIRDDMYLGAGNAYMREVGAALDDGYKQGVLPQRPALVNLQCDIDHPTQSMADLAWLREHFGSLENLKGKKIAMTWAYSPSYGKPLSVPQGIIGLMTRFGMDVTLAHPEGYDLIPDVVEVAKNNAKASGGSFRQVTSMEEAFKDADIVYPKSWAPYKVMEERTELLRANDHEGLKALEKQCLAQNAQHKDWHCTEEMMELTRDGEALYMHCLPADISGVSCKEGEVTEGVFEKYRIATYKEASWKPYIIAAMILSRKYAKPGALLEQLLKEAQERVK
The following text describes a protein:
Function:
Efflux system for nickel and cobalt.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKYKTGLVLLVIALALLVYFSPWFFLHIASWQKEFNQLISENLHQIQNNSIKAGTTLIFASFVYGVLHALGPGHGKFIIASYLSTHESQLKQSTILSLLSSLMQGIVAITATTLLVVVLNLSSRYFKLSQLWLERTALLLLVFLGCYWIWQGLRAYRKKAKLAIKSLNPLPLHEKSAVKNNRTFQPNTCSCGHQHLPSPTQTAQATNLKSQFLVILTIGMRPCSGAIFVLFLAYMLDLYSWGILAVLAMSFGTGLMLSAFAGIVRYARNTAIHLGHWYSSKNTKGKSESIVKLIAGGIMLFFALSLLYGTTISTGGSKILF
The following text describes a protein:
Function:
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
Subcellular Localization:
Mitochondrion.
Sequence:
MFNSLLSGTTTPNSGRASPPASEMPIDNDHVAVARPAPRRRRIVVAMTGATGAMLGIKVLIALRRLNVETHLVMSKWAEATIKYETDYHPSNVRALADYVHNINDMAAPVSSGSFRADGMIVVPCSMKTLAAIHSGFCDDLISRTADVMLKERRRLVLVARETPLSEIHLRNMLEVTRAGAVIFPPVPAFYIKAGSIEDLIDQSVGRMLDLFDLDTGDFERWNGWEK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAAPAKLDDLEMQLFFRPHDLKVIQSDKTSPYSAPQDWEDLFDYDTYSDLHQKLIDNNFEKPSSIQASSIQIANGEDHPSILGQAQNGSGKTLAFVVNSLLRVDRNSSKVQVVILVPNMELVDQTEEYFQKLAPEGVTYTKIDKNGADIDHLGQIVVTSPGLFFNAANAIPQLKDIDVFVVDECDEVITNKIYHEDLIKYAGEIKNAQFLLYSATLVDKLNDFINTFRPNMQRIILPQKNVINRTNKHFFIDCRKGMDKIDAINIMFQYLFQFQTFIFFNTRKYLQKVQKQLEALKLECDWCSGDRTKDERRDVVKKFREQKIKVLLTTNLLARGIDIPSCKVVINFDMPRKERGEPDYESYLHRQGRCGRFGKEGKVFNLIRDDEDMKMIEYIKKTYSVEITQITPQDVQKFAEKNK
The following text describes a protein:
Function:
Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex; Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems.
Subcellular Localization:
Cell surface. Secreted.
Sequence:
MEHYTKQKVKDRIKPKFRGTSPAERCADGPFSSPLSICGSQFPAMALWVLLLLAVLPVTPSASPRCAPQCPPGTYPHPPSRTRQRCGPPRGRSEPVQCRELRCPAPLSFPHGTLEPRFPAYSSGSVLRFTCDDGFVLRGAAELRCRPGGVWSEPPPVCDDGEGDCPPPVIPAGGVTTGRGRHHGAEVRVRCGAGLQLLGPSQRHCMETGRWSGPEPTCRNPYSYDLPEDISSGLGSSFASILELAGAHTEKDTSLGRRIVLNRNGSLHVYVLLDASGSVQQDNFELFRQSAVAIVDRLSSFEVPLRFAIVSFASRTHIIISTTEDDASDADVVIARLEAMKFGVHGNATGTNMHEALLEVYHMILFQVERSVRDGQPNAWRDTRHVVILLTDGRFNVGGHPRDAVAKIEDVLEIKGDRAEYLDIYAFGVGTLEVDMAELEAVATHRRDERHAFKLADASALRQALEGALAATAIGDLCGVIIPAGTARPPWHVVLRTGAQQRCAGTLLGGRWVLTAAHCFLGGESPHVWSAELAGGQEVSIRGWNLHEDFDIRGRAAWGVPEFYDYDVALVELEKEVGDTGAPRRICIPCTEDANRALRMAPGTTCQKQEAELLGHTRVPAEFVSLEGKRLSVRIKEREERASCLRGAVQPGMPHANASVKDVVTERFLCSGQESGGEHEDMACKGESGGSLFVERRHRFLQVGVLSWGTFNPCHRGGRNSEGGLLRAPAPRGHHPRDFAISLFRIQPWLRRHLGGVLRFTPV
The following text describes a protein:
Function:
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Vacuole and punctate structures.
Sequence:
MSLNSEEDEAELVQLQPRYNGEDTSATTNRELNGWYAYPIAAEVFAVVAVGAFLPVILEQLARENGYFFSDSTKSCVDHGGSRRMRAEDGLKGSEQCMIKILNSTISTSSFAMYTFSAAVIVQAVTLVCFSSFADHGPYRKKMLMAFAYTGSVASALFIFISPTVYFLAPILVIVGVTSLGCSFVLLNAFLPLLVANHANNTGAKFATADSSSDFELEALNPNTQCGQSHARSAHMSSRGVGYGYMAAVFVQVISILILWLFSKTAIQKRHPSLPIRVILLLVGMWWAALTTPTLLWLRPRPGPPLPSQEAKTLSAPTSRFRTFLFYTRFSLRSFWRTLLRAISLRQTLMFLISWFLLSDAVATISGTAVLFARTELHMGTIAIALLSITSIGSGIIGAFAWPRVQKRFSLQPKTILLCCVAGMEMIPLYGLLGFIPLFKKLGFIGLQQPWEIYPVAVLHGIVMGGVSSYARSVYAPLIPEGSEAAFFALYAVTDKGSSAFGPALVGWLVDHAGSIRPAFIFLAVLVVLPAPLLWMLDVEKGREDAKAMADGEGRGRGTYERVREE
The following text describes a protein:
Function:
DNA-binding protein that binds to the NRP-B promoter to activate the NRP-B-mediated cell death response. Functions as an upstream component of stress-induced NRP-B-mediated signaling to connect stress in the endoplasmic reticulum (ER) to an osmotic stress-induced cell death signal. Exhibits transactivation activity in yeast.
Subcellular Localization:
Nucleus.
Sequence:
MEVISASSLNPNAPMFVPLAYRTVEDFSDQWWNLVHSSPWFRDYWLRECFQDPQFQNDDAFDFDFDLDLQDEDEKERKEGKEVVSLGVLKWRSCGGGWAQAPRYVEKAPKFVKPKVSPRAIHQPR
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
Sequence:
MQTYYIFVTGGVISGIGKGLFAASLGMLIKSYGYDVVMQKCDPYINVDPGLMSPYQHGEVFVTDDGAETDLDLGHYERFLDTNLTRLSSVTTGSIYSTVIQREREGGYNGMTVQVVPQIVDEIKARMRCFELISTVPGENSEPQRKHSAPLASTQKRFVIIEIGGTVGDMESTAFLEAMRQLIDDVGRCNACSFHVSYIPVLSNGKELKTKPTQHSVRTLLSVGIKPDFLVCRTDTHLPKETIAKLAHSCGLSKDHVIENFTVQSIYQLPLLIKHVPALVFNLFNVIPIRATAEKEAEASLDKWSEIVERFIHPATLSTGDALACKEYDKKSHIRIGLVGKYVELRDAYISVYEAIHHAAAHSNCYVDILSIVSDTCEGADRASSSTPAPKAQSAEPAKFEEKLHTETSNFVPATVTLENVDAIIIPGGFGSRGVSGKLEAIKYCRQNNKPILGICLGMQCMAIEFANNVLNLKDATSTEFDPETTNPVIATIISEDVKAANPLAATLIRGSGGSMRLGACNCTLLNGTLAQKCYQCKNIRERHRHRYEFNGRYKTLFEEAGVVFSGLSTESSLVEIMEIPSLDFFLGVQFHPELLSRPLKPHPLFVGLIGAALAKKRGM
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRRININASVALWTVFTILTIWISFALHQPDVQTCDIARTWISTAHVEGFDSKHSRFGEKYSLHLIRASQHAIPQPIRPSGVPVIFVHGNAGGFRQIGPFAGIAQELNDELRLLTKGDAGTEFDFFSIDFNEAYSALHGRTLLDQAEYLNDAIAYILDMYKRNQQEGLQVPESVIVLGHSMGGIVSRVAVTLENYRPQSVNTIITLASPHLIPAATFDADITKVYHLVNDYWRAAFAEGDTNDNPLRDITILSIAGGKSDTMVPSDYVSLDSLVPATNGLSTFTNSIARVWTGIDHDAVMWCHQLRRQIASALFHIVDPNVPSQTKPREVRMSTFHRSFSGSQSLSSAMQDFINIEATPLQDGVEQRLAPGFYWGRNLQMLTNHVINYDSNIDLYERKSGSLLKVWQCRSRQGSSFRQCKRIYPLFVPGINDSVLSHVSVNGILLLDVSKEASESGDWINIDETSMSAAPFNIYGNIVFSTSNMVSQDIAFPALTSGLISYKVLTSGGVGLIRQYMGRNHPSRTYDSKYLIPHYARVDISFHGDGAPFVPFKLKTPTKTDLSTKSYKAPLHLQVFGQGKVTISVDYVGSLGNLFMRYRTLLFSLPTAVLYAVLLLQFWRYYQSGSDAKFLSLRDATGLFIKQYLSWACLVVAGLSFVIKFEFIRDFLHFIQIPATGSSKSYEIETFYGSLYTHIDLFLGISGPIGVVLAPAFLALATGIVVVVTEIVIAVTTLASLAISRGHRKMSLLQTPKNVTIQSSDDPIGDLLHKRTVIIALMALLVLLFVPYQLAFALATASLLALTAYFDAEESASASHDLSTSLYANRQAQEKVGSFINYATTMSVVMVWTTLVNIPVLAVWVQGMVFGRSTIFSSHHNLLSVLPTLLFIENLSFRRMPERGLPFVTYIILGYACFNCTAYGMMHAFMIHHWFNLLAGWLLITSYKRNKTVIKESRIE
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Sequence:
MKTVVFAYHDMGCLGIEALLAAGYEISAIFTHTDNPGEKAFYGSVARLAAERGIPVYAPDNVNHPLWVERIAQLSPDVIFSFYYRHLIYDEILQLAPAGAFNLHGSLLPKYRGRAPLNWVLVNGETETGVTLHRMVKRADAGAIVAQLRIAIAPDDIAITLHHKLCHAARQLLEQTLPAIKHGNILEIAQRENEATCFGRRTPDDSFLEWHKPASVLHNMVRAVADPWPGAFSYVGNQKFTVWSSRVHPHASKAQPGSVISVAPLLIACGDGALEIVTGQAGDGITMQGSQLAQTLGLVQGSRLNSQPACTARRRTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIDGGKQKRCFTDIRDGIEALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHHFPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNAHRCLDWEPKIDMQETIDETLDFFLRTVDLTDKPS
The following text describes a protein:
Function:
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots; Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MENLFESFTEELEQDFQLRQNIKEIMTKIEPIDRKLSQMVQTYHQVNNTMSYQQLLEEIQPMKAQIDQLKLLIKPVLYYKYRDYWKFSITQISFSLIFSYWVEKKSLLKIDQVQSILGLDENKPGSFSLELEDYLIALCNLSNELSRYCLNCVIKQDYETPSLISKFISDLFAGFRLLNLKNDIIRKRYDSMKYDLKRIEEVVYDISVRNLIKK
The following text describes a protein:
Function:
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: Strongly expressed at 13.5 dpc, then down-regulated. Marginal in adult. Protein may be unstable.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein.
Sequence:
MSGSSGCPFFLWGLLAFLGLALVISLIFNISHYVEKQRRDEIYRYSDDYIPRVDEYYVEDAPIYGNLENIIPEPLDENCYEQMKGRPQRSASDPQEVAAPAQVPAEAQMCYASLDHSVKGKRRRPRKQNTNVSDRGKDTQVYTMDANVSQINMVESFPPDNQVVEESIHDDPARLFGLIRAKREPVI
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Sequence:
MSRDKAQKRQRDIWVEKETYTLLENFIIYKSVLNGAYSSSVTKERKNSIWREITATVHNEHPDCTEKTQEQVEKKWKNFIAAARVAIRNYNNGLTETGGGPLGEGGILRPIYQKYYEEVLGLDNPAVSATAIPGGIDTEDISTLTRNVPAQQQLVERIAGRSDNHDEEDLNENFDDTSMTSVVAAVTDNGNFSKEPEECEFYFNLETSNSPGSSLSTTPTPVTGMLAIEGSDSISANSTIDKGKRLVGSASVAKRLIYNSSTPTIRVQGGQTTPSPSPESQFPSTSSAFSVLKQKRESLTLRQTMKKTKYSLCDLGESTAQSRLTEQRLKVLSAVMDVREKLKNPVLRDELPEDLIDLLYNLKENV
The following text describes a protein:
Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MRRLAFRGAGCALVKLKKLESMGSKRRRATSPSSSVSGDFDDGHHSVPTPGPSRKRRRLSSLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDINLLTADFQLLFNNAKAYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTMADGSSPGYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMTKSSLRISNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFHQLYDTVRSCRNNQGQLIAEPFFHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMMEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKDKRKELGPLPDDDDMASPKLKLSRKSGVSPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPSRPPLTFDIIRKNVESNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIRIRDELCKNGEILLSPALSYTTKHLHNDVEKEKKEKLPKEIEEDKLKREEEKREAEKSEDSSGTTGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPETFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDEEKSTDNSDDNRAEDSFNLEKEKEDVPVEMSNGEPGCHYFEQLRYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMSCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIIPQKEPSPLLEKKIQLLEAKFAELEGGDDDTEEMGEEDSEVIEPPSLPQLQTPLANELDLMPYTPPQSTPKSAKGSAKKESSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKAAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGVMNQGVTPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPTGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLENV
The following text describes a protein:
Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MLLPMKTTQKNRTMEGRMGLLFLLVLGGAWACDGRELANCDQLSKLSRKSDVCALCEEYTTNALDYLNENKTQLEIIDILHNTCYQLHSFKQKCITLVDYYAPLFFLEIATIQPGEFCLKVNLCQLITYISLQVQEDTSGFCEDTVSTLLAKLKDGDTKLQIIGTSLKVCNSVEKYANKCKRMVFEYGPLVFDNAEKFLESTDICTAIYAMQIFNSGWPANLSFRFLWKQRSNRFVVYLLQKIAIYITTH
The following text describes a protein:
Function:
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Sequence:
MIEIKVPELAESITEGTISQWLINVGDKVEKGGSVVELETDKVNVEIIAEDSGIVSKLLGEPGDTVEVGATIAILDANGAPVAVSTPAPAAEQPKQETAETPKAAAPSAEQTATLQGLPNTNRPIASPAARKMARELGIDLNDVRSTDPLGRVRPHDVQAHAAAPKEAPAAPKSPAPAPVAKTEFEKPVERVKMSRRRQTIAKRLVEVQQTSAMLTTFNEVDMSAIMELRKERKDAFEKKHDVRLGFMSFFTKAVVAALKQFPLLNAEIQGDELIIKKFYDIGIAVAAPDGLVVPVVRDANQLNFAEIESEIRELGKKARDNKLSLKELQGGTFTITNGGVFGSLMSTPILNSPQVGILGMHKIQVRPVAIDNERMENRPMMYIALSYDHRIVDGKEAVSFLVAVKDMLEDPKSLLLEG