lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for 60S ribosomal subunit synthesis.
Miscellaneous:
MISCELLANEOUS: Present with 15000 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSENNGNPLDLSSLRNKISSKLRDNNSKKAKKTHKGKDVKASSNSKKVNEDIRREALALGASEEDLKLIQGLSDDDDAKSEQEFDAVADEDADDKGFKNDLQNFMKNVGFDQHKLEDVDDDDIEEESTSSKESKIPAQEKEHAQSNIASSTIEKTSQESIDNGSEQEENTVEEANLSSDQEPESESAEKEKKEEKDGGLITQTTIISSDKLIIPYDKPWYEIPLDPQVGQNDDVEELSKEQIEKLFERGKQTLEADNQTYYEEFTKDSSQAKFMSQILSDGTLNDKISAVTLLIQDSPLHNTKSLETLVSYCGKKSRNSALQSLNALKDLFLNGLLPNRKLRYFKNQPGLSMMLNKKTLAIFYFEDYLKKLFFRVLEVLEVLSHDPIIHVRLQILNHVFDLLTNQPEQEFNLLRLGVNKIGDIDSKVSSKASYLLLKLEQAHPNMKSIVIDAIVDIALRPNADYHTTYYSVITLNQTILKRSEDSVANKLVKTYFTLFEKFLINTDKDNTNGVVKSNSKSYEEKRKKNFKKGKHGGKSVKIEKTENEVLDEKNSKLFSALLTGINRAFPFAQIPASVYEVHMETLFKITHSSNFNTSIQALVLINQVTVKAKLNSDRYYRTLYESLFDPRLVNSSKQGIYLNLLYKSLKQDALNVERVEAFVKRILQVCSHWLNVGTITGFFFLLIQLAKTVPQIKNLLTNTPVDYEYESDAEEEQGDKDIKRKEYDGRKRDPKFANAEKSSLWEINNFINHFHPTVKTYANAYVTGETEQIAKPDLGLFTLSHFLDRFVYRSAKQTNTARGTSIMQPLFSGSRVNDSVLVKASDIMHDQGPVNTEDWLTKKVEDIKPEDKFFYQYFTTKKTADGKGKKSNKASNFDSDDEMDENEIWSALVKSRPDVEDDSDDSELDFAEDDFSDSTSDDEPKLDAIDDEDAKSEGSQESDQEEGLDEDIFYSFDGEQDNSDKKRSFAESSEEDESSEEEKEEEENKEVSAKRAKKKQRKNMLKSLPVFASADDYAQYLDQDSD
The following text describes a protein:
Function:
[Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane. Low oxygen or sterol conditions promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes required for adaptation to anaerobic growth; [Processed sterol regulatory element-binding protein 1]: Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein; [Processed sterol regulatory element-binding protein 1]: Nucleus. Note=Accumulates at promoters of the target genes.
Sequence:
MQSSIPSVSVSVASPAMETPTKASPDSKSPNSVGAIPSSSPLASSTKASTSTPFVENCSNLLCDLASIVEDSPPTLTNTSLSPHSFSLSDMESSMSNWLNPFAFDNTMNSAPPLFTSTNMGSPNSLENSTNPLLSNCGSPNSFQNETFTGPSLNEFDADDKIQRQMKILHSVDTIDPSTVQNYPSADMSNPEVKLKTEEIITPMDTTCKPEPSAKKIKLSPSSEDSCSIPETLPFSAPKSRGSLSPSETPDFVAGPGGKPKKTAHNMIEKRYRTNLNDRICELRDAVPSLRAAAALRCGNSLDDEDLGGLTPARKLNKGTILAKATEYIRHLEAKNKELQKTNKQLSDRLAFYEDPSMAPPSNDTRAVNSVNVVSSSDYSVHQSSRPNLTQRAFTSPTLNTMGRTALNGMVGLGLFNYFGNDSSQSVYGLFALPPFLMSPFTGTVLFNMLKIGVVLLGLFYLLHDNSLFKGFKGEKKSKVSTRSSMSPSSILFRKTVFEKYCLLDHSTSTISLFFGLLIFTLKSAYGYLTHRLSALYTSSENWVYSEQQLAEVRNMEKLLDAQLMGGDAKVDRLRLLMVFASSFSLPPSSHTCALQAMYCQLIFSNTSVPSAIVSKCVAFFWNAAKKQHSKSSVHAELRELPECTANLIENSHADDVFSPNMVERLWVLAKCTRDSAQMSDSIISSLSDVLVLSPLEVLASWYAADLLDALLMESLSRKVEISEIEEIISLCPKNSSIIRHALLAKLVLFPENTADSLNEVLAAYKNTLDLCSQDKRKQSSVLKINLSKLFTLHSCLSLALQRLGYGDVSKRMYQEIFVPDSDADITPLSFIISWTALNTFAPICTSPKENDVVEKMAMYVRTAIGTLKIQDLKLSRKLINSCIDIGSRLQEDLGYVSSA
The following text describes a protein:
Function:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Subcellular Localization:
Endomembrane system; Single-pass type I membrane protein. Lysosome membrane; Single-pass membrane protein.
Sequence:
MFVLPFLDSLPHYTAVCSLLASSMMFSISGKGSIVVWNLVIQLVMCGRTVFASSDTKSCKLVSESESERKVLSRLEGLAHKNFTVEHNIGKESYTYVFQLCGDAGGVKGAGVIQLDKKNPNKPTVVGMYTDTQAIGGSDWVMLIYRSGEAYDQHCSQEKRKAYIMISCNRNTDMGQLEVVVEDRNRSTDCFYLFELDSSTVCPAIESHLSPGSIILIIAFVLLALYLVGGFLYQRLIVGAKGMEQFPNYAFWVEVGNLAADGCDFVCRSQNREQAPAYRGVTTEPLEEEPDERDDHLLPM
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MEDSGNGKGSFFACYLLTSLNPRYKGCHYIGFTVNPRRRIRQHNGELTSGAWRTHRKRPWDMILCVYGFACQVEALQFEWAWQHPLKSLVVREAAGRIPSSVRGLKKQFYLLFTMLNCDKWSAMDLNVQFFSSKYIDYRKGCPGLPPHMGLSIAPVESLPVTAEEADSELDMEMEKETERGGSRETSNVEGSRDELFDVESRSFDFEEDDLNPPIVPQDCWSNGTGRVESLDRAKKQSKLPDASKFEGTSASLYTSSISQPLVISTKVSGTLEEVEAENLRDRRQTADTPIADNFSIRTVPMVNTDLLRTRHRHTRGPTLRTEAESSFSVCILETPPTIPCRAKTIAGQDAPAQSKMEMKPIRDIQECESRCSDDWCELPSPQALSPLPYARSALDSDTASPFSALLERYSLKQPSSIVKRCLQQKANECNTTRPESSASTQDLRKNSLPVNVACTPPCRPRVVVVIPDDTPIMSSREVIDLTDSPY
The following text describes a protein:
Function:
Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRKNTIWNYSLIFFCCVLKSISTLDHGPHTVSVDSNRHNTQHQYKQNPNVASQRHSSHESGQSLHNSQSEHVTHIAASHAGSGGEHSTHLAQNLHRSSYNLLSEAMSQAVSNEFSSMGSGSADGACAADDFDCYSGSVQDRFGMEAIASLHRQLDDDDNGNIDLSESDDFLREELKYDSGYEKRQKAFHFNDDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVDLFKLHKVTGAALPRLAVNNLQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRETGTRWKDYILVTLLLSAIIGCWYAYQQNKNAKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDLERRLKEAPTLSSSNSDLEVQQLKKEIEMLRNELSRAEFELVDNCWSPPPQLQSWLQYTYELESKNHQKKRTSAEKQLQSAREACEKLRKKRSSLVGAFVSTHGKSIDDVDRSIVEARNALGDVTNELQERLHRWKQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGMSSTKGSRARITNSTEDLDDESIQGKLNFENFSLLATE
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMQHKEIKHPYQGIKYTVLVVIAAFRVANALTTKTFFQPDEYWQSLEPAHRLAYGYGYLTWEWHEGLRSSLPPLVGAGIYKALQLLGLDDPRIVRIAPKIVMALFASAGDVYTWKLSARLQGPAEAPWALFVSLLSAFNWFFLTRTFSNSAEMVLTAVALNYWSFNGKEVNFKRLSVALFIGAISCVLRPTNAILWAVLGLHLVLTTTAKMRVLWLAVRNVALVFAATYYIDYLYYGEPVFPLLNFLKFNLLQSLAHFYGTSPTLYYFYEALPLLTVGWLPLTLWGLWINRSQVLVKAALAVVVAFSLIRHKEVRFIYPLVPILHMAAAEAITQTPKKLRKWLVWSLALVNILVAGYFSQVHQRGVVDVVEYLSTEPQVTSVGFLMPCHSTPYQSHLHRDIPVWFLTCEPPIGFTAEEQMTYRDQADQFYDDPLQFVQTQFPESVAVSAREARTPLFHPSHLAIFESLEKKSPEVIEHLVELGYKRGKTFFNSHFHDDWRREGDVVVYNL
The following text describes a protein:
Function:
Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments. Promotes human PERP relocalization to punctate structures throughout the host epithelial cell cytoplasm. Promotes localization of human PERP to the apical cell surface of mucosal epithelial cells during infection, may thereby promote host neutrophil transepithelial migration.
Subcellular Localization:
Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 T3SS).
Sequence:
MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTHLVDKAAAKAVEALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNSQRHIDNSNHDNSRKTIDNSRTFIDNSQRNGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDVTAHATAEAVTNASSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKTDTLQSDTTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFDARETFLGVIRKALEPDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRLKGETDYVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINEVGLVIEEGDKKLKFYPKAVTNSKDIGIVDLAIVFVKSTKTEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRIIVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKRLENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEMVTKKIMKDAVIEAVKVANAKGLSFNEEEMIKKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTSVNETLTNLIISLEKK
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein.
Sequence:
MATPREIKKRINSVKNTRKITRTMEMVSTAKSKKISDRVNASHPFSNKIKELVSSLASLGGVVHSPYLRRPEKIKTVALLIITANRGLCGGYNSNVNRMAKAKIQEWKKSGVNVRLFIVGKKGISFFKFAGEKAEKTYTHLDDKSGYREAEEFANLFLELFAKEEVDVVEIASTVYYSSASQKPEVTRVLPLEPAGEGSVSDMMVYEPSPEKVLESLLPLVVKTAFLKAILEANCSEQIARRIAMKSATDAASEMIKLLTRGYNRVRQAKITQEISEIVAGADSLN
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence:
MAIADNNLYVKEEIVKKYIPLVKYIASRVIIGKTKYIEYEDLVSYGMIGLMDALNKFDESKGMKFSTYASIRIKGSMIDELRRNSPISKGAMDKLNRYNEAIEKLQKKLNKEPNLIQIADELNISLKEVSEIENYINYISVISLEDLIFSSEDEVPLIGTIKDEKSPSPEKHVEENEQLDYLAKAIELLNEKDRLVVTLYYYEELTLKEIGKILNVSESRVCQLHSRAIIHLKKAMAKLKYN
The following text describes a protein:
Function:
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.
Subcellular Localization:
Secreted.
Sequence:
MSNASRKPGGLWFPHRCHPRPSRGHLSSTAQAPPPSPQTQRPERLTREPTMAPFAPLASCILLLLWLTAPSRACTCAPPHPQTAFCNSQIVIRAKFVGTAEVNQTDLNRRYEIKMTKMFKGFSALGNASDIRFVDTPALESVCGYLHRSQNRSEEFLVAGNLRDGHLQINTCSFVAPWSSLSTAQRRGFTKTYAAGCEGCTVFTCSSIPCKLQSDTHCLWTDQFLTGSDKGFQSRHLACLPREPGICTWQSLRPRMA
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MEGRQVFFSDGLGCACVPREVVSSAAMMMLEPGRVTLLADMVLSWKRPAGSLQPVHCRCSRAFVRDRELYRSEMRTSWPADAEGPVPDEEEEEKEEDEEAIDEETQLMASMGLPLTFASTSDYKRTKRNIHRRPEPFEEEEEEEEEEEEDETTETDGGKEEDGCHGADGDEEHQGDGWNSYWAQHGEALLWTGWSEKHPEGAEGTAGAPWDDPEMRSMWDEHASEIYCSYWERFSYWASQGWTMDGNGGGGEAAAETENRQEEELSTLLEGSCTFAADQEASREGEGGGQQLEAELGGSERPSDGGGDEQRPAGPPQQHTAEQTVCQQNSGSSNGHHDSRKPISQRDDDDDEDEDDENPRRQTKVKRSHEQDEEEFPQLTPQEAWTELGLRHDPGLTFDSVLSFKGPGSLRQKKQRKTKRSVCGVNKHIRFPEAGEAITPSQSSSAVQKAQSFLEKVQKEAQRNQMDHTDEGGATAAKPPPVNEGGESRSTEMRGARREKEEGAEKDGSSSGSSSEESTLKHEQPRFPISLSTKAAERDMEEEEAEPPRRQLGDLQTPHFLQSDAPEDLKEKVKKPKKRSKRRKWQQIPAEVEADSELAKYWAQRYRLFSRFDEGIRLDREGWFSVTPERIAAHIALRVKHSFPTSELVIDAFCGVGGNTIQFALTGKRVLAVDIDVVKLDLARHNAEVYGVAQRIDFLQGDFLQLAPRLRGDVVFLSPPWGGPNYLTAEVFDIRTMMEPDGFEIFSRAKQISDNIVYFLPRNANMDQVVSLAGPGGMVEVEQNFLNNKLKTVTAYFGNLIKLDSGDPK
The following text describes a protein:
Function:
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
Sequence:
MGLYFRVRKSDASARLSELKTKSGTLILPEFFPVYNPNKPVITPREMSEMGIKAIITNSYLIYRSPELREAAIERGIHSLLGFDGVVMTDSGAYQIYRYGRVDVTNSEILRFQHSIGSDIGSILDVPMSSEIGREEAESGVERTIRNAEEWASMREELSNTLWVGTPQGSIYRDLVIKCSERIRELDFDYNGVGSIKVALEKYDFVTQVDHFMSIRSILRAGKPFHFWGIGHPSTFAFFAAIGADSFDSASYSLYAEQGRYMTPHGTLLLDEIEEFPCSCPVCSSHDPKEVKAMSKEERTKLLAKHNLYISISEIKKVREAIRGEWLWELVQERSRFHPNLYFALMHLLRRYSSLLEAREPLFKSSGLQCSGPESFLRPEVVRARNRLKYIHYNGKFRRVLYGDVPLGLKYLYPFGQTICPYDEEVQDEPEDDEIITCVLSYQYEFPFPKLPAIMRRSKSTGTLREVSLEGKVIGHFRPNDGAFIPTLDGASLILSHLPYPKGRVVVKGLFSDTVARGTTVFVKFVKEADPSIRPKSEVIVVNESDELLATGKAVLSGVEYHQYHPDHPFIIIRRHVKPRSEEKPPEVDS
The following text describes a protein:
Function:
Binds to all microtubule populations.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
FPRRVIKPPGGEDSDIFGVRSPQPSSPGDLSLQTPRKVKNYQQSSIFTPSEDDLPTTPSSGASTPTRRRLSDNSQERLFGAEDVGTPRRIVDRMKSNIFSEVDSPAPQAPVPASASKKFGKGRALLRWDVYHLPAQQLKTRKCHGYSSNGSTSPLDSPPNGHVQYPSGGRPSGIF
The following text describes a protein:
Function:
Inhibits trypsin with a Ki of 0.25 uM. Inhibits the trypsin-like proteases in midguts of larval H.armigera, S.exigua, and P.rapae.
Miscellaneous:
MISCELLANEOUS: The reactive bond is likely to include a lysine residue.
Sequence:
KELLDADGDILRNGGPAYPGLMPGVERDLPASGWGLPRRTGDESCPLNVKAVR
The following text describes a protein:
Function:
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle. Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MPLCLFECLCEADLQQYYPHFAAVGLQKIDELAQITMKDYSRLGVERMEDRKRLFQLIQVIQSVAQEEKKERTPLQPGCVYPQLPYDGSGARRQLQFDASIEAQSHLHDFSHKHSVNNPGDSVSMASPADPRYCRNINSSGTEAGPTGSAKKQNTKTPLHRGSAPDLSDGDIPVIHRVAHVLGYNYGVPQTCTRLEPTEKKGPWTETDRIRVCVRKRPLSSREERRGEVNVVSTEDKESITIYERKEAVNLKEYLLQHVFYFDEVFSETFTNQDVYIRTAYPLIQHVFNGGNATCFAYGQTGAGKTHTMIGTQKNPGLYALAAKDIFQQLETVQLKSDCNVWISFYEIYCGQLYDLLNDRKRLYAREDGKHVVQIVGLREVQVRSVELLLEMILKGSRERSTGASGVNSDSSRSHAVIQIQMKNSKNRKLGRISFIDLAGSERASDARESDKQTKLEGAEINQSLLALKECIRALDQEQAHTPFRQSKLTQVLKDSFIGNSKTCMIANVSPSHIATEHTLNTLRYADRVKELKRGMKCTTSQSAHGRPAACVSPKRVQNAPAGSGDKISPKKVKLGQQHIAASHQAKSKSCPSVFHPTIIPLSSTPKNCSKTSTVKENTRDAGLNHTTPVKGTLRSGAIVKKRNGKLTDGLYPVFQSHPISKIETACDTKNIKRENIGIQKPPKVQIIQAVQPVQKEIVPRPSLFSDDDYRTLSDGLQDEGPRPIGNVKLAWAGMHPQQKEREQHLRSYHKQFQQPPIFQQKLQYQPLEKIFAQYKAQAIKVTSNVGHGHSSCSQSQMSPLEDLDDSDFSEDSFSYSSNHKKGRNKVEFGERISFYLHQDSPELDKSSEVKKGLHFNDKDSQLFDQGVGWRHGINSSYTQERKHTEATSWSPQMDSNGILNITIDSPEKPYSSQEDLGTPLGKQNNSQHNLSLDKAIGLSLNNSTSLKEHSVHIKAKDSSEGCISISSDSVSGVMAPLTVSLLQDNWSFGSDPCLVPRELSDKSADIAKSLSLNEGWSADAQPNKGKLPSDDPCGHKSGMANKCIQYNKAINTPCGDKGWFPGSGSHSYCPSSSRWCVKVSGNANLSPRGKQNETSDLTDTSLDILLKSSGQSGSQLYDADTEETTDAMKDVGNVNKTENESLSDKNTTDSNDLPLNGNRESPSFKETFRLPLRDDELVCLKAKLLQCLCDQGGIKKEPPPNCVHTDTPKGPKNSTTLSSQTSPTEGHGQKPRAQERAQQLVIQAHREQLNEIADLCSREEVLLSQINASDFKEYVSKLDEILSVKSKCIQSMQAQLHLFLAYSMAEEPRDKAFA
The following text describes a protein:
Function:
Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.
Subcellular Localization:
Nucleus.
Sequence:
MSQHIRKLDSDVSERLKSQACTVSLASAVREIVQNSVDAHATTIDVMIDLPNLSFAVYDDGIGLTRSDLNILATQNYTSKIRKMNDLVTMKTYGYRGDALYSISNVSNLFVCSKKKDYNSAWMRKFPSKSVMLSENTILPIDPFWKICPWSRTKSGTVVIVEDMLYNLPVRRRILKEEPPFKTFNTIKADMLQILVMHPMISLNVQYTDKLRINTEVLFRSKNITEGLTKHQQMSQVLRNVFGAIIPPDMLKKVSLKFNEYQIEGIISKMPVGLKDLQFIYINGRRYADSAFQGYVDSLFQAQDFGEKGMSLLKTKSVGKPYRSHPVFILDVRCPQTIDDLLQDPAKKIVKPSHIRTIEPLIVKTIRSFLTFQGYLTPDKSDSSFEIVNCSQKTATLPDSRIQISKRNQVLNSKMKIARINSYIGKPAVNGCRINNSTINYEKIKNIRIDGQKSRLRNKLSSRPYDSGFTEDYDSIGKTITDFSISRSVLAKYEVINQVDKKFILIRCLDQSIHNCPLLVLVDQHACDERIRLEELFYSLLTEVVTGTFVARDLKDCCIEVDRTEADLFKHYQSEFKKWGIGYETIEGTMETSLLEIKTLPEMLTSKYNGDKDYLKMVLLQHAHDLKDFKKLPMDLSHFENYTSVDKLYWWKYSSCVPTVFHEILNSKACRSAVMFGDELTRQECIILISKLSRCHNPFECAHGRPSMVPIAELK
The following text describes a protein:
Function:
Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility.
Subcellular Localization:
Cytoplasm.
Sequence:
MFPYVVAQLKKVRKRQPAKRQGLPTDCLIEEEMKSILKIWKGDVTESVLLLDKVIPKIPKYKRGGIAGTVYNQSTFILPMLREAETIGSYKPPEKEITLESMLQDLLIDGYHMVFEEINNLILIDAKERKEYEKLYGAHKAKPLHEQLDTIQFIAQFLKDAETAKNNDDFSLLFTCHLNLARTFAQGENSLAVRFFDLCMKIASEYPCDKDGSSLALSQLYFGLYAKSNDKNSSLIVASMLNLGNFYTTKGDFTRALEILKECLQLCEEMMDWKGVASASQSIGAVFFKLDDLDKAKEYYGRFIEVSDEGEDKHVLTESYLETGFAFNNAGHYNVAKEYVKKAFGSEITSEYETKARSLYGIVHAHSMYSLYLPYVNRRSSYALETLLNWKDFRIDNFEEKPIRPKNEEKPILRREVVMKKKIKQYDDIKDSSTTLPVFLSHIQPYNLEPKSVGSLRSDDVEDLVDYSLLNNNSFVKNAVTTYAAHSGAQNIDLSAISLHVKANTQNKSLIELIQTQMNLERPHRDNRYES
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MVWTVGDWCICVPESIELLSQSVQKFCGCGPHSYTAKHFLHAPGHRQSPINIRPDEVKLDPRLNIKRLTWKYPKETIELLNTGYCWKAHVPTEGATLSGGPLSHDYRLAQYHCHWGENDHIGSEHVVNGQSYGAEIHFVNWNTKYGSFNEALKYGDGLAVLGVFLKVGKENPELNKLCELTNDIKHKDECTPFRHTLDPNKLLPQKGAYYTYLGSLTTPPCNECVIWIVFVEPIEVSHEQLESFREMMSMKKGGCSQPSREHKILNNFRPPLSVEERVVSLGYL
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Mitochondrion.
Sequence:
MNNITRDIYTKGQPADLKRLLMKRNSFRRPLLNMRCNSVLQYSLEKRKLTVQDLKDTRMELNNMIRILTEAMAAHEWTVDNVNIADIQSLQSTIHSTLKNFQKINVLQLNINASDNSLAYLSKPEESYNFLTIYFSTLLSYEKVENLIKKSLTVIDSLYGLLNYQINAQHSLGCIPLNQDSFKQLKLLICILEEDIKLDDCGLEISASKNEYLEKIKTHYKTWLRIHTFLTLFPVPSVLSSNLKKQMYGWFEDLRDESLKSIILASLSE
The following text describes a protein:
Function:
Rapidly hydrolyzes choline released into the synapse.
Sequence:
MTAVAATGKQVDVWNSVPFGQPPVGELRFRHPRPMDPWDGVRDTRDMPNSCWQTMDDFFGNFAGSTMWNANTERSEDCLYLSVTVPRPRPKNAAVMVWIFGGGFVTGSSTLDVYDPKILVSEENIIYVTLQYRVASLGFLYFDQPGAPGNMGMLDQVMALQWIHSNIAFFGGNPNNITLFGESAGAASVSMHLLSPLSRNLFSQAIMQSGSATAPWATVDREETIIRGLRLAEAVGCPHSRANLSATLDCLKTINASTLVNNEVAPLGILEFSFVPIVDGAFLDESPKRSLATRNFKKCNIMMGSNTEEGYFFIFYYLYNLFPKEENVYINREQFLQSVQELNPFANSIARQAIIFEYTDWSNPDDPIRNRDALDKMVGDYHFTCNVNEFAHRYAEMGGSNNVYMYYYTHRSSTQLWPTWTGVLHADEINFVFGEPLNPTKGYLPQEVALSKKMMRYWANFARTGNPSKSPDGSWTQEYWPVHTPYGREYLTFAANHSWVGRGPRLRQCAFWKKYLPSLKTAAGRNDDQT
The following text describes a protein:
Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions. Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which leads to courtship suppression through release of tachykinin from a cluster of 8-10 neurons in the SEZ.
Subcellular Localization:
Secreted.
Sequence:
MRPLSGLIALALLLLLLLTAPSSAADTETESSGSPLTPGAEEPRRVVKRAPTSSFIGMRGKKDEEHDTSEGNWLGSGPDPLDYADEEADSSYAENGRRLKKAPLAFVGLRGKKFIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAVGKRAPTGFTGMRGKRPALLAGDDDAEADEATELQQKRAPVNSFVGMRGKKDVSHQHYKRAALSDSYDLRGKQQRFADFNSKFVAVRGKKSDLEGNGVGIGDDHEQALVHPWLYLWGEKRAPNGFLGMRGKRPALFE
The following text describes a protein:
Function:
NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release.
Subcellular Localization:
Cell junction, focal adhesion. Cell membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MALSCKSWLANECGKHLLLLVWLATNVWLFWKTFVLYYSGPQYFYLHKMLGLGLCVSRASASVLNLNCSLVLLPMCRCLLALIRGSQKVTGRKVRRLMDKSKTFHVACGFVICIFSVVHVVAHVGNTLSFSVRYSEELPALNMARYRGEDPRVIIFTTVPGITGVLLVVILFLMFTASSYCIRVSSYEIFWYTHNLFIVFYILLLVHVAGGVLKYQTNVDAHPPGCFRPNKTIQNPRSKMKPAPDPFFDDLPASSITDNFNRICKEEPHFQHHFPETWLWVSGPLCLYCAERLYRYIRSSAPVTIVSVVSHPCDVIEVRMVKNNFRARPGQYIVVHCPNVSSFESHPFTLTVCPTERKATFGIHLRVVGDWTARFQELLLPESNLDLEILPIVQQRRFPKLYIDGPFGSPSEEVFNYEVSLCVAGGIGVTPFASVLQTLLDEWQHYKLRRLYFVWVCREIQSFYWFADLLCALHQKLWQENRPDYLNIKLFLSKAEGLQNIRGERYRALNSRLLLGRPRWKLLFEEIGKYNQQKCIGVFCCGPKEISKTLHKLSNASNAFGTIFEYNKESFS