lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Subcellular Localization:
Secreted.
Sequence:
MHRRLLGRDALSASRRLRRHRGRPGGSSGWAPRRRRPRHAPEVGQAELQLLAGLVAGDVVGGRAPLPKSSPLSADSAPERGTAISRRLPSRRRSGCCHPLSPARRPRAAMWLLLALLQAAVLPARPCEAPAEAAVAVRALGARLLGLAMEPGPDADPGIYVGLRLGSDHDLSTEQRYLQRLQDAFQGRYGRSPHAASSPSHGHRHRNTDSMPETGRLALYLLGLRATCPPPDPAPQRFPVTWLKYYLEKDWAGTRHHGHPLTSYYQYGLGVLALCVHHKRVREEVIQRLLVAEKHQRFGHADGNTVDTEAVVALAFACLKKEKHIRARLAAELRAAVRRARARLVEAQSADGLIGNAFSTPMAMQVFIATDTCRTQPAYGRAMAALLQHLDSFTSAATMAQALLALNGRSYLGIASMQCQEELDTLTPIFLEPLPPGPRNMTVRLVVECPVPRCPQQLLYDSPVPAPAGASLLDLLRAAPPQGSQNFTFETQDTAYGPFLTSVQGMAVRPKEQHYWQLLSGLGTSLQMGVADYRPEDGNTVILRLSKW
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MVVHWTIVDEIRLLRWASEFKPAGIHKHFHMFCIVERMNSPDKYPVTLLQKETMKLGKVFTAKDIWDKLSQSYNLEKIDEMENTYSLEATTESSRNGNGNGDDAEIHEETLLELNNRIRVRKQDFTLPWEEYGELILENARKSPNSNEEYPRVEDMNEKDSTIPKESPSTDLKNDNNKQEKNATIKVKELPEYHTEENDSPIDVQKEPIKEVQSDEKELQREHMSEEEQKMKSTNKTAAPVRKSQRLKRSKEVKFEDEEKEEIEEDNTKDEEQKEKKEEIQEPKITHNEEVDKEKNENEEGDDEREKSTSYENTNGSESEGVDEGVDEELGYESEREAEGKGKQIESEGGNLKKKTENKKGDDQQDDTKKDSKDKNEPLAKRTRHSSSTGNTSNETSPKRKRRKAGSRKNSPPATRVSSRLRNKK
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSPAEQGSLTMNFELTLPNERHAQIVHNSLRIDKEPSKNKIERTLNVEGPKLIVSWKAKDSRSLRVSVNGFLELLSLVLDTIGDFDLQLTNTTNYAYDVYGVLNFLTAFEPSHRAKPIRGSMKPRLKAEKREVLSGGRLLELANFQKLGKKFTVLNNLRF
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MHGLNQSASMLRSKWMEALEPQISAQIMEIHHSKHHQTYVNNLNAATKQLQEAVAANDVVRQIALQKAINFNGGGHVNHSIFWKSLTPSSSDGAKGGAKLKEEIAKQFGSLDEFKAKLKADLLALQGSGWAWLVSYPDGTLKIEVTSNQDAISAPGAVTLLGIDFWEHAYYIQYYNNKAAYFDNLWEVLNWDFAEKQWAQRPLAKY
The following text describes a protein:
Function:
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTYETWEENVVSFSEEDETKGALSVLNWAYKEYKDEVVYACSFGVEGMVLLHIINQVNPSAKVVFLDTNVHFQETYELIRKVRERFPSLNIIEKQPELTLDEQAKLHGEKLWESNPNLCCKIRKILPLEKSLVVEKAWISGLRREQSETRKHTKFINQDHRFQSIKVCPLIHWTWKEVWRYVYKHSLPYNPLHDVGYPSIGCEKCTLPVGDGGDSRDGRWAGKVKTECGLHYQ
The following text describes a protein:
Function:
Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (By similarity). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors. Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses.
Subcellular Localization:
Postsynaptic recycling endosome membrane; Lipid-anchor. Cell projection, dendrite. Postsynaptic cell membrane; Lipid-anchor. Note=Associates with lipid rafts.
Domain:
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer; The N-terminal region, which is highly basic, is required for interaction with calmodulin.
Sequence:
METSVSEIQVETKDEKGPVAASPQKERQERKTATLCFKRRKKANKTKPKAGSRTAEETKKHTPEAGGSGQRQPAGAWASIKGLVTHRKRSEPAKKQKPPEAEVQPEDGALPKKKAKSRLKFPCLRFSRGAKRSRHSKLTEDSGYVRVQGEADDLEIKAQTQPDDQAIQAGSTQGLQEGVLVRDGKKSQESHISNSVTSGENVIAIELELENKSSAIQMGTPELEKETKVITEKPSVQTQRASLLESSAAGSPRSVTSAAPPSPATTHQHSLEEPSNGIRESAPSGKDDRRKTAAEEKKSGETALGQAEEAAVGQADKRALSQAGEATAGHPEEATVIQAESQAKEGKLSQAEETTVAQAKETVLSQAKEGELSQAKKATVGQAEEATIDHTEKVTVDQAEETTVGQAEEATVGQAGEAILSQAKEATVVGQAEEATVDRAEEATVGQAEEATVGHTEKVTVDQAEEATVGQAEEATVGQAEEATVDWAEKPTVGQAEEATVGQAEEATVGHTEKVTVDQAEEATVGQAEEATVGHTEKVTVDHAEEATVGQAEEATVGQAEKVTVDHAEEATVGQAEEATVGQAEKVTVDHAEEATVGQAEEATVGQAEKVTVDQAEEPTVDQAEEAISSHAPDLKENGIDTEKPRSEESKRMEPIAIIITDTEISEFDVKKSKNVPKQFLISMENEQVGVFANDSDFEGRTSEQYETLLIETASSLVKNAIELSVEQLVNEMVSEDNQINTLFQ
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTKRNPKLAALLSVIPGLGQFYNKRPIKGTIFFIFFISFISVFYSFLNIGFWGLFTLGTVPKLDDSRVLLAQGIISILLVAFAIMLYIINILDAYRNAERFNRNEEIKDPKARMVATWDKTFPYLLISPGTFLLIFVVVFPLIFMFGVAFTNYNLYNAPPRHTLEWVGLDNFKTLFTIGVWRKTFFSVITWTLVWTLVATTLQIALGLFLAIIVNHPVVKGKKFIRTVLILPWAVPSFVTILIFVALFNDEFGAINNDILQPLLGVAPAWLSDPFWAKVALIGIQVWLGFPFVFALFTGVLQSISSDWYEAADMDGASSWQKFRNITFPHVIYATAPLLIMQYAGNFNNFNLIYLFNKGGPPVSGQNAGSTDILISWVYNLTFEFNNFNMGAVVSLIIGFIVAIVAFIQFRRTSTFKDEGGL
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLVNFLLVGFGAALGAMLRYGISVLVKSKWKTNFPSATFFINITGSFLLGFLVSSALGPVWQLFLGTGFMGGYTTFSTFKVESMELKWKTNYRVLFSYLGFTYVFGLIAAFLGMMLGV
The following text describes a protein:
Function:
Catalyzes the conversion of 2,6-dihydroxypyridine into 2,3,6-trihydroxypyridine in the nicotine degradation pathway.
Sequence:
MSPTTDRIAVVGGSISGLTAALMLRDAGVDVDVYERSPQPLSGFGTGIVVQPELVHYLLEQGVELDSISVPSSSMEYVDALTGERVGSVPADWRFTSYDSIYGGLYELFGPERYHTSKCLVGLSQDSETVQMRFSDGTKAEANWVIGADGGASVVRKRLLGIEPTYAGYVTWRGVLQPGEVADDVWNYFNDKFTYGLLDDGHLIAYPIPGRENAESPRLNFQWYWNVAEGPDLDELMTDVRGIRLPTSVHNNSLNPHNLRQFHSKGESLFKPFRDLVLNASSPFVTVVADATVDRMVHGRVLLIGDAAVTPRPHAAAGGAKACDDARTLAEVFTKNHDLRGSLQSWETRQLQQGHAYLNKVKKMASRLQHGGSFEPGNPAFAFGLPKVDEPSVVTNS
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP.
Sequence:
MIIIGVKRNINNSNNSNSNNNSNKKKDKIMSHNNNNTITGKNTNEIMNNNNNSNNNNNNNNNNNNNNNNNNNEEVKTEPIQQILKRLNSKNKIEVGATPNDIPTSIPSVKNLGKKYDSKAETHLLNQKVLSSPSKEVNSLKKSTNGTNTIPSSSIPSSPPSSPPSSSSLSSDRTSQDIPKSVNGLTASIVAKFSKNIDNNTTNNNSNNNNNSSLSTPIQSPRDSLETNPIKDEESEESEESEESKEEEEELKMGIKTTKTTSETIESSYSTSQLLKNDLIQEKGDDNNNIQEPQQPKYPTQTSFITDKSKRLSTPPINGTSISIGNNNNNNNNYINGNSGINTIPRNFQSHRVAGDWKDRKLNTLFTQGTVGGNGQNGTVRKNLIGTRELSTSSGILQCKDDSSSKDQDFEFNNSAGSSGNSSASNSNRNSIAFSSSNHFSSESSQSAPTLPIYNPSQYTSPSTPQSPSPSPSPPLISSKSIYINKPPPPHFNQQTNFSVSPTKSPSNEKQQQEDEDVKHLVRAFTNRKLNVHHAERKSKISVQDAEWIVKKFFHDTDRQSKFVLSENRTKDLNQPSSQFSPSTSPSTNSIPTNLLLSNKRLSTSLPNINTNINNSSNNTSSSSSSSSTTSSPSPLTTSSSTSVLPPPLSSSSSSQLTESLKTRIEENNNNNNNKNINNNNNNNNNNGRNSIHDSQEMTELEDPHSSPSYRHLEEVGKKKYVSAEPSRRPGIKTPLFLNVPTLAMPTQFHQIPPERVSSNLFSVSVEENSYPDNPLLFNQQIINRVANDKDLSYLFFPVLKSSTKITSSTLNNIIPINKLNNQIHNNNNNNVIISNNTGNNNNNNNSSKNNNTVKGNKKQQNKSSSSSQNNSPPSDFSLSVSPSPCSSLTPSPSPSPSSPLIESSMFTKDLSPPPPAAAAIVLQQPVATTNNKSTDKDSRKSLWSSMKSSKPPISTSQPSTIQDTISTSPPSTSTSPTSNSPPTSISPPPPSITTGSSPPSTAGTSPPNDNGNNNNNSNKELTISIPITNVNVHESNIVVASTPRSGRDLATIVAEEFKDRTDIVFCTQHLSMNRIKVRSASLDAMIDLLTNHRLSQPDLVESFLLTYKTFTSPLAVLTKLIERYEETDNINNNNNNNNDDLIISTRTTATITNEDEDNSNSNSNSNKTNKNSSRTIKLGVLSIIKCWVDRHHYDFERNKALLSAIVAFLEGPVIDDGMEKVSNIILKIIDRKANEAEARRTGTALVMHTSTSHCKFPPSIPPSLSKPDQIPTLQNFDDLEIARQLTLIEHEAYSMVKPNECINLAFSKSDKEIRAPNIINIIKRSNLLPLWVATEIVQEERLTKRANIIKKFISIADQCKNLNNFNAVMEILSGLNLTPVFRLKKTWETLPRKYLATFRHLNSLMAPKFNFKVYRDVLHTKNLPCLPFLGVYLTDLTFLEEGSFDQAENGLINIVKRTQIANIIQEIQQYQQLSYSFAPVPIIKDFLLQIGGLQERALYKQSKIIEP
The following text describes a protein:
Function:
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Sequence:
MSVPNVDPSHQSNASANEATRPSPAAEGLDKSGERVREMFRQIAPRYDVMNHLLSLNIDKWWRRKAVQTLKIKGDDPILDLCCGTGDLAIAIADSAGSDVQVIGSDFCHAMLEIARVKESKRTRDTAGGSGRHTIPFLEADSMALPFDDDAFQCVTVAFGLRNIADTDQGLSEMARVCKPGGQVLVLEFSQPTLPVLKQAYNFYFRHVLPRIGQWMARNDKSAYEYLPESVGKFPCGDALAGRMRDVGLQHVTFRPLTLGVATIYVGEKPGGKTDHAEMAAHREREALVAT
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MIRMEGEGGRGRRRRRRMNSMDLNLYLGLPLSQLPRTPDLGSDLALGSSSSSDLPIGESPPGTVADMSTFRDLSDGNQIPYSPSNPESASVDVFVADLDFQPVREIDGDLGRNRDGDNPVVLDRVEPYLPADILFDRDGRSSSRHDDRLTPEAYRFGTLIQSNHPVRDRSLASRRFRASLPYIGEQSSNVSSLQVAASTAVCAGDSIEKSSKNKKNDYGVDKEDLTEESEEQSGAIAGVNFECNICFELASDPVVTSCGHLFCWPCLYLWLHQYSDHKECPACKGQVNESNIIPIYGRGCSSEVNNAEKDSDPGNLKIPQKPHGHRIESTRQQRATLRRSAVVEGVFDPFRHILSDMSQLEGLLDPSLSHFTGRSDQQQQQHDQPNESGRQERSMESSAMQQLIDHRRMMTRLRARRLLRMPENQEMPSIPNHPVSTTATTAAAAAAIGIASRIPTSLSSPSQVTNTMTSSDPHVHYSSGMSASERLTAVHSDLMRLVSRFARNSVPPSFMSEAVPAVVGRNNQNNSQVIFNTQLTSGGGAHSTSTNTTTDQASASSSTMAIIQGDSPPAPAVAAAVIGTSAEPNIAGTSRSTSSRRRGRSTASCLADNNGSVHDNKRRRSN
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). During SAGA-mediated transcriptional inhibition, SPT3 and SPT8 prevent binding of TBP to the TATA box.
Miscellaneous:
MISCELLANEOUS: Present with 8430 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDEVDDILINNQVVDDEEDDEEMLSGLENDSKQDLEGNDDGGEDEEDDDDDDEDDDDDEDEREDDDEQEDDDGEDDAARMDKTATPTNEHQHDEQKAAAAGAGGAGDSGDAVTKIGSEDVKLSDVDGGVGSREASSSTHEASANGEVYEYYKHMLNAAQIADSYNIYPTAAIPIQTHVNALAVSRGLKYLFLGGSDGYIRKYDLLNTLEGKLSLTILQKHSLAESIQNAGILQSYWENEIPQKKSEMKLSANKTDYEPKVSPVHSLEVQSECLFILSGLQNGGITMQGVRYMEGSIAHYFKGRNGHTQIVNILRLNGQEDRFLSGSWDKRLLEWDLQTGDIVNEFKKSRSELSSLEMRPLYSSVDVSGNVNSGKENENADDDMDSLFGDEDEDEKQDAGNEPVETGDGSNGEENKEQISEESLNIVYDESVFMTSGLNGSVHIWDRRMTQSPALSLERGAGVPPWCLSACWGVDGDHVYAGRRNACVEQFDLKMPSKPIHNLKLPSISGPVSCVKAMPNNKHLLCASRDNIRLYNVEIAVDASNSTTKSSKVPFLIVPGHHGGIISNLYLDPTSRFIISTSGNRGWQGNSTDTTLIYDIDLE
The following text describes a protein:
Function:
Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. UAF seems to stimulate basal transcription to a fully activated level.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSSINGLNESEGSTPLSTASIIGSSEQLYMTHDERYLDVLQQYEVETENKRDFDLEEEQWGVLSGSCVDGTYWSAEEKELFFQAVARNGKRDLDLIAYSIPSKSAVQIERYINALENELRWLRNHVDASVRSQCLLKYEDIPIAMEMSQNWIDWEEKIAERLLEGSNISGVETSHYNAQSVKNKTSNEDLFDTNEMRKISERFYHFDRQAPFPSNPLSAGATEFLLQIIKSKLKELIGTSIFLAESRFRKLEANNAFHRKPIIKNRDVVLSGKFLRFHRFNIPGFWKYLPTRQKMNVYKRNKRLKFQNYIHIMESDERQSKLKLGRVRARKTKNNENTMFFDSKEHSTDESDGNLGEHDVKRKVDSVPADETSINGFKKSVNQAEYPDNAQMFMDESVAEESLVEIDDSVEAYDMIQSKNYESFVWKYVLHLTDEMSTEDALFETIPLSNLLAQKRMKDKLKGSDVFTTLKITSKSLHNIDEHSDSDDEVQPICYYYKDPVVSHAPGAAEVVSELESGYVGLISYDLSNLPNSTEDPERKLAKPVSSWELSLPLK
The following text describes a protein:
Function:
Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of different MutL heterodimers that form a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats, the repair of heteroduplex sites present in meiotic recombination intermediates, and the promotion of meiotic crossing-over.
Miscellaneous:
MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSLRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSGINKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWRVSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRLRALRSHNDEYSKILDVVGRYAIHSKDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFNKSVASNLITFHISKVEDLNLESVDGKVCNLNFISKKSISPIFFINNRLVTCDLLRRALNSVYSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQLHAELSAIDTSRTFKASSISTNKPESLIPFNDTIESDRNRKSLRQAQVVENSYTTANSQLRKAKRQENKLVRIDASQAKITSFLSSSQQFNFEGSSTKRQLSEPKVTNVSHSQEAEKLTLNESEQPRDANTINDNDLKDQPKKKQKLGDYKVPSIADDEKNALPISKDGYIRVPKERVNVNLTSIKKLREKVDDSIHRELTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDFANFGKINLQSTNVSDDIVLYNLLSEFDELNDDASKEKIISKIWDMSSMLNEYYSIELVNDGLDNDLKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDMVPKVDTSDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILKDVVEIANLPDLYKVFERC
The following text describes a protein:
Function:
Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRFHMKSGSEDNDIVAATATAEHIRKFVFSGSPAERLEIKIPELLQGAYSFYTWPCAPILAHFLWERRQTLAGKRILELGSGTALPGILAAKCRAQVVLTDNCILPKSLAHIRKSCLANQLQPGVDIDVVGLSWGLLLNSVFRLPPLDLIIAADCFYDPSVFEDIVVTVAFLLERNAGAKFIFTYQERSADWSIEALLKKWKLQALPISMEDIGKESGVDLLEFMGGHTIHLLEITRIESDGSINTT
The following text describes a protein:
Function:
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.
Subcellular Localization:
Cell membrane; Lipid-anchor. Cell projection, neuron projection. Cytoplasm, perinuclear region. Nucleus. Perikaryon.
Sequence:
MGTVLSLSPSYRKAPLFEEGTATVGHYTAVQNSKNAKEKGLKRHSLISVLPWKRIAAVSAKKKSSKKVQPNGGYQSNVTHLNNENLKKSLSCANLATFAPPPPSSSSSSSAAALPPAQKNPPGGPAAATATPRRVVVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISAEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCLRRPQEGERRGGEGPSAHRARPVNPALPRRRLRRRGPLTPSVPPPPTPRRPRRRALLVPPTIPFAVTPAEGPRRPTDDPH
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MFSELGIALLTVAAFANGAKENVREFSDLCVLYSFLARPVPVPVIHGTDGTKSTPVTSVFQTALNEVIKLNLTVIDPKMSAVLADDKKYDKAAKILESQDVKGYFDKLSAETVQTMINEYPTIKPGEKEDKNFMKKFKVPVSESTATNVRPLMANLAAAAMQIKSELDTKLASLSSTRTRIRKLTVTAMFGQAVAENPTQPITADTQLDTLLTAQNFPWSDSAARDAACERPESNSAGPGKAIAADVVCLCSEHKNAASDSCTDTATSDTDNFGVGSGMKLKAFNRWKQLQTKCKEQNPAKAVTLNPTAITAALSAVFGNLGKNAITQASVTGKAATPVERHSYLGAYVVGGTTPTTCTSASWDPGSTAGKGLCISYENFLNKGKQVPWAAAVLDVADELHNLEDANADIITLYSRVCAIKKQMETLLLMGELLTPAAGPVLTTTTLKEKTVEEQNKFARFNSNETDCTTNGCDYDKTKKECKPKPGTENTAPPTGTGTAGATASTGCARHKDKTECDADKTGEKQNCAWRKGKEGEPEPEKELCRNGSFIANKKLALMAAAAFMCFLF
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MTSTLKNEITSAFTTVGLTSLPAPLVTKLTGLSTSLRLTPRQLAEAWEAHSLTRNVDVLDDVTFGGYQSALAKEAESKGLIASSSVDSKRNVVVMQSSGLGKRTAPHSSVTPSPMAKRGAQTPQSASGATAPADRSGLSAVDNLTTPSGKVPISPGMKHPGVASANQITPTAKSAPKYQDRTGTGSLVTSYNPNSLPTAVEVNAQNADNATTQKTCTIQYHPSSTHPQPPTKSTPFRHMFTPLATRAKALESRILTMSDSICEKYNIKSEEEEMLKYEHVSAEVVDDNMACWTPVGIPKQGKVVCVGRICNEAHEGRLNRASIRLEGSRKDSSGSRIHLDLNSLVTNNDNNQSYSFFPGQIVAVEGINSSGRTMQASRLYEGVPPPVEKSTAKELIKYNYGPDGQNGMPLSIVSMCGPFTTKDNLEYDPLVDMVMKISEDQPDVVIMCGPFVDGRQPLVQGGEPTITDEDGNEKKVSYENLFQTKFAALLEEMYANDPDMKTQFVLVPSTEDMICESVYPQPPLVNQEVTSGVKKFNDEFGNLGLNYVEIAGRENIKTSERTKRVHCVSNPCTLKINELSVGVTSSDVLFHISSDETNANLPPGGRLTRIAQHLIQQRSYYPLFPAAKGACLDLSRSDEWEMPVQPDILIVPSKLTTFARKVLDTTVVVNPGELTKNTTGGTYAVIDVHPMKKEALEKGGDAEMEHGVQDRVRVDIKRI
The following text describes a protein:
Function:
Unlike folt-1, does not appear to act as a folate transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEQWKVMVLICMYGAVKEFRPTEPYMYEYQHTVLNMSEQTLNSQVYPIWTYSYLITLIPAFLLTDVFLYKPLLVFEAFSYFLCWVIFVFGKSVWSQQVLEVFYGWATATEIAYFAYIYVKVPKTEYKSATAFTRAALLVGRFLAYALAQLLIGLNWTSYSTLNIISLVAMTIAVFLALILPGVEWKEAYEKKLEDNNVQGNLKEIVDQSSYMDYLRMFFVGLRHNLMAIYRNPLILKWSVWSALSSCIFYQVTNYTQTLWGTLPESANRYNGITEALVPLLGIPADLITRQLNVNWNRWGDLLLAVGSIGQAGLLFWMSQSHHIVVLYLSYIFYRVIYQLTTTIAQSTLAFSLDSRLFGLLFGINTFVALLLQSILTAVVIDWQKLDIRPQFVVYSCYHLVVAFGFAIIFGIWASRRFFKTSTN
The following text describes a protein:
Function:
Active on a wide variety of primary alcohols and their corresponding aldehydes, but not against ketones nor secondary alcohols. Active on aliphatic compounds up to 5 carbons in length and aromatic alcohols, less effective on branched-chain primary alcohols. Prefers NADPH to NADH. Its catalytic efficiency is greatest for aldehydes, suggesting the reduction of aromatic and medium-chain aliphatic aldehydes is its in vivo activity. Plays a role in tolerance to internally produced ethanol.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKAYAALEANGKLQPFEYDPGALGANEVEIEVQYCGVCHSDLSMINNEWGISNYPLVPGHEVVGTVAAMGEGVNHVEVGDLVGLGWHSGYCMTCHSCLSGYHNLCATAESTIVGHYGGFGDRVRAKGVSVVKLPKGIDLASAGPLFCGGITVFSPMVELSLKPTAKVAVIGIGGLGHLAVQFLRAWGCEVTAFTSSARKQTEVLELGAHHILDSTNPEAIASAEGKFDYIISTVNLKLDWNLYISTLAPQGHFHFVGVVLEPLDLNLFPLLMGQRSVSASPVGSPATIATMLDFAVRHDIKPVVEQFSFDQINEAIAHLESGKAHYRVVLSHSKN
The following text describes a protein:
Function:
Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Membrane, coated pit. Nucleus.
Sequence:
MRGPAPFPPALGTRVRGKMAAPLIPLSQQIPTGNPLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLNMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSIKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSTSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTNEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGKVQLETIIKSLKSTQDEINQARSKLSQLHESHQEAQRSLEQCDQALDGAHGASLTNLADLSEGVSLTERGGFGAMDDPFKNKALLFSNNAQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFAEQQTASTDPFGGDPFKESDPFRGSAPDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSGPFGTLDPFGSGSFNSAEGFADFSQMSKPPTSGPFTSSFGGAGFSDDPFKSKQDTPALPPKKPAPPRPKPPSEAVAEQKNPALYTLLGGKSTPVSQLGSADFPEPPDPFQPLGADSSDPFQNKKGFGDPFSGKDPFAPSSSAKSSKASSLGFADFTSFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALSKADMPAA
The following text describes a protein:
Function:
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity-inducible transcription.
Subcellular Localization:
Nucleus.
Sequence:
MEKSSSMKQWKKGPARGKGGPQNALCQYRGVRQRTWGKWVAEIREPKKRARLWLGSFATAEEAAMAYDEAALKLYGHDAYLNLPHLQRNTRPSLSNSQRFKWVPSRKFISMFPSCGMLNVNAQPSVHIIQQRLEELKKTGLLSQSYSSSSSSTESKTNTSFLDEKTSKGETDNMFEGGDQKKPEIDLTEFLQQLGILKDENEAEPSEVAECHSPPPWNEQEETGSPFRTENFSWDTLIEMPRSETTTMQFDSSNFGSYDFEDDVSFPSIWDYYGSLD
The following text describes a protein:
Function:
Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis.
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGYPPPTRRLGDKKRYHYSNNPNRRHPSAVYSKNSFPKSSNNGFVSSPTADNSTNPSVTPSTASVPLPTAAPGSTFGIEAPRPSRYDPSSVSRPSSSSYSSTRKIGSRYNPDVERSSSTTSSTPESMNTSTITHTNTDIGNSRYSRKTMSRYNPQSTSSTNVTHFPSALSNAPPFYVANGSSRRPRSMDDYSPDVTNKLETNNVSSVNNNSPHSYYSRSNKWRSIGTPSRPPFDNHVGNMTTTSNTNSIHQREPFWKANSTTILKSTHSQSSPSLHTKKFHDANKLDKPEASVKVETPSKDETKAISYHDNNFPPRKSVSKPNAPLEPDNIKVGEEDALGKKEVHKSGREIAKEHPTPVKMKEHDELEARAKKVSKINIDGKQDEIWTTAKTVASAVEVSKESQKELTRSVERKESPEIRDYERAYDPKALKTDVTKLTVDNDNKSYEEPLEKVEGCIFPLPKAETRLWELKNQKRNKIISEQKYLLKKAIRNFSEYPFYAQNKLIHQQATGLILTKIISKIKKEEHLKKINLKHDYFDLQKKYEKECEILTKLSENLRKEEIENKRKEHELMEQKRREEGIETEKEKSLRHPSSSSSSRRRNRADFVDDAEMENVLLQIDPNYKHYQAAATIPPLILDPIRKHSYKFCDVNNLVTDKKLWASRILKDASDNFTDHEHSLFLEGYLIHPKKFGKISHYMGGLRSPEECVLHYYRTKKTVNYKQLLIDKNKKRKMSAAAKRRKRKERSNDEEVEVDESKEESTNTIEKEEKSENNAEENVQPVLVQGSEVKGDPLGTPEKVENMIEQRGEEFAGELENAERVNDLKRAHDEVGEESNKSSVIETNNGVQIMDPKGAVQNGYYPEETKELDFSLENALQRKKHKSAPEHKTSYWSVRESQLFPELLKEFGSQWSLISEKLGTKSTTMVRNYYQRNAARNGWKLLVDETDLKRDGTSSESVQQSQILIQPERPNINAYSNIPPQQRPALGYFVGQPTHGHNTSISSIDGSIRPFGPDFHRDTFSKISAPLTTLPPPRLPSIQFPRSEMAEPTVTDLRNRPLDHIDTLADAASSVTNNQNFSNERNAIDIGRKSTTISNLLNNSDRSMKSSFQSASRHEAQLEDTPSMNNIVVQEIKPNITTPRSSSISALLNPVNGNGQSNPDGRPLLPFQHAISQGTPTFPLPAPRTSPISRAPPKFNFSNDPLAALAAVASAPDAMSSFLSKKENNN