lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.
Subcellular Localization:
Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.
Domain:
The LisH domain is required for the activation of histone gene transcription.
Sequence:
MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKTKETSNNVPAIMSSLWKKLDHTLSQIRSMQSSPRFAGSQRARTRTGIAEIKRQRKLASQTAPASAELLTLPYLSGQFTTPPSTGTQVTRPSGQISDPSRSYFVVVNHSQSQDTVTTGEALNVIPGAQEKKAHASLMSPGRRKSESQRKSTTLSGPHSTIRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNNIAQVPKQTDNNPTEPETSIDEFLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSISSQPMESNPSIVLADETNLAVKGSFETEESDGQSGQPAFCTSYQNDDPLNALKNSNNHDVLRQEDQENFSQISTSIQKKAFKTAVPTEQKCDIDITFESVPNLNDFNQRGNSNAECNPHCAELYTNQMSTETEMAIGIEKNSLSSNVPSESQLQPDQPDIPITSFVSLGCEANNENLILSGKSSQLLSQDTSLTGKPSKKSQFCENSNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSCLQSEILPVSVESSHLNVSGQVEIHLGDSLSSTKQPSNDSASVELNHTENEAQASKSENSQEPSSSVKEENTIFLSLGGNANCEKVALTPPEGTPVENSHSLPPESVCSSVGDSHPESQNTDDKPSSNNSAEIDASNIVSLKVIISDDPFVSSDTELTSAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAEVGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFSANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQGLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKPCHRRVLCFDSTTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLKPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQSEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNVLSVGTAVKDLKQEQTKSASSLITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTKKRKIEELDERERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE
The following text describes a protein:
Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
VEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWPLEEQFIPKGFEAKSRSSKNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF
The following text describes a protein:
Function:
Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSATKSAGPTTLANHLDKEVKTDVLGAIDSDKLTEATQGDHKAINEEYKIWKKNSPYLYNVVIATVMDHPTLTVEWLPDLFDDITPGSMSARLMFGSHSSGLDKDYIHVASVELPTHLRPETIGLLSQQEGGTDMKQHHDAHGRHKRIAIVQSIYEDGEVNVARYNPLASKQIAAAHVTGDIHIFDRNNIMNSKEEAKPIYNLKHHTKEGWGLNWNINHADQLVSGAIDSTVAFWKIPEAASDGSCKDVTPHTVYHHDAAVNDVKFSYKMDFLIGSASDDCTLRLWDTRKPGNKAACTIKESRGINSLDFNPHSEFLVATGSADETVKVWDMRKMDTPISQLYSHCDEVTKVQWCPHQPSVLASGGHDRAILVWDIARLHDDLSSDENDEGPPELLFHHGGHSSRISDFDWHPTLPWVIASAAEDNVIQVWRMAESISNDEAVPADDVDMED
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVNLLEDINFLRYYCTFLNTFLVVPWYDFKKNIICYPFLAKLYATCLILIRISLIVFTCTDQKLMQIWAQSLVMSQKFIMVFLISNLIIFSTYSIANSAFLDISRWINLFKNLRLVDKIFGKHEKNGHYLSKRFLCVFIMKHISFICITGHEIYTWSIFIDMPFYKIFLQTGYVDLVFEFFLIMFMAALLKSFEVRYKTLNKKLIHISNQKMNQVEVKKFMQIYRILGQNIQIFNELFGYPIVFMLFHFGVGAVSCLNFLFVYGIMTQPEMALFHNMIIGNICIILQILLNFLTILSSINATAREAKNFLQSCYRIREEFLHDSINLQALDKLIEHSKFFMQEFSTNGCFTLNKSIVFSLLANISTYLIITLQLNESQYQNVTAQNCSSIAKPI
The following text describes a protein:
Function:
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MSWLNNLAGKAESLLNNIDQSAAEVIHKTVEQEEEVGVTAPVEDQLNKSFPQSSHAAANAKSAQLSRAKAHTLRRAAEIGKKKKVEDALFDFLNSDEKITRSRSVPVTPRITKSKSESGKLSSLSRSSSTADVDSKGSPNVPSTFEISRSSSFESINSKVMSKLNEEIGSAAAEQHETPSEGDAMTLPDSTASESEFEMVGSSAARSDRDSPSTSSIAESASMMQQPSNDIGMENRMLRTELASLHQELTQTSERSKKIREEHPHVPCMNINTKIIISDLQQTNRDLRNQCEDLQEEIKVKHSQLSAISMKLSEVQQLYELEKENTKQLKVENERLFLDQSEGSGMHARAMEELRSRLQEAEDTLAQERNFRNDERQEALNQRSRIESETQKIVETLQKSEHDRQSEKRKLDDISTEIRSLKNNLSSSKQELADYKQKAARILQSKERVIASLKGSGENDLSSSTINSLEAEEAMQERDQAKDEINSLRIEISDLRSEMQEVEEQHQEDMSSMHQELSEYKKNFQIESSGRREADAEVSRLQEEIRRNEEDLIRSRSSNQARLRDKEVEVERLRNQLMVRSQSSPQESELESRLRQLTEAVIQKQTQVESLSSEKSSLIVQMERMEGQIKRLSQEGGRQVSLNMEDDVVRNRGNMSHIPEFGGGGLDQGMVGKVRKAASVLDKFSIRLGIFLKRYPPARLFVLIYMGLLHVWVMIVLLTYSPEIHGHDFLSEAKPG
The following text describes a protein:
Function:
GTPase-activating protein for Rho family proteins. Essential component of the CLIC (clathrin-independent carrier)/GEEC (GPI-anchored protein-enriched early endocytic compartment) endocytic pathway. During hematopoiesis, inhibits Egfr-ras-MAPK signaling by promoting Spi-induced Egfr internalization through CLIC/GEEC endocytosis, thereby preventing plasmatocyte overproliferation. Essential for normal mushroom body (MB) development and consequently the formation of olfactory long-term memories. During MD development, required to stop the MB beta-lobe from crossing the brain midline, possibly acting via its role in the CLIC/GEEC endocytic pathway to down-regulate the Egfr-ras-MAPK signaling at the tip of the beta-lobes. Required during embryo cellularization for maintaining and regulating the rate of actomyosin ring constriction. During cellularization, inhibits Rho-GTP levels at the furrow canal tip in a spatiotemporal manner, thus delaying the onset of actomyosin contraction and ensuring appropriate closure of the cells at the base of nuclei after membrane extension.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm. Cytoplasmic vesicle. Note=During embryonic cellularization, detected at the furrow canal tips with enrichment at the edges. Recruited to the furrow tips at early cellularization, expression levels are highest during mid-cellularization but then decrease at late cellularization when it becomes predominately cytosolic. In embryos and larvae, displays a punctate localization in the cytoplasm of plasmatocytes. In larvae, also displays a punctate localization in hemolymph crystal cells. During Egfr internalization, localizes with Egfr and spi, to punctate or tubular structures connected to the cell surface.
Domain:
The Rho-GAP domain is necessary for inhibiting contractile ring constriction during cellularization.
Sequence:
MGGGKNVRRGLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENKKKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARDDEKLTLFSCQRRASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSINNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHLKPHH
The following text describes a protein:
Function:
Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.
Miscellaneous:
MISCELLANEOUS: The reaction proceeds via a thioester-linked acyl-enzyme intermediate.
Sequence:
MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGKGVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGVLNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSINGKKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRPETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERNAKVFG
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MAAMLGTTLLALSLFLFNVAVSHGALQFGFYTGKCKGTDVETAIRGIVAARFAKDPTILPALLRMQFHDCFVRGCDASILLDVPNSEKQAGANQSVRGYELIDEIKAALEKACSGVVSCADIIIAATRDAVVLGGGRRYEVQTGRRDGTISRASDVNLPGPSISVSDAIGLFNAKGLTAEDTVLLLGGHTVGVTHCSFILSRLYNFNGSGKPDPTMDPALVATLRRRCPQNLVVDSPVNLDQNASSANTVDDSFYKQIVAKRGVLQIDQRIALDAATGATVALLAGGRMDFSTRFGSSMVKLGAVEVLTGTQGEIRRSCRAPNKRTQSLGGDPFVIEPFVQEQLQSSAVVPR
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MGTGTYGEVGRTIHQRSGTHIPQILDPPLLGDSDCKREGKHVEFMPPIMGENLKAANQFELMAPSIAFKSYPYSEVPQYSGGNVAAACGESLVHQNIERSVHNGRMILPIEVKEEPMYVNAKQYHGILRRRQLRAKAVLEQKVVKSRKPYLHESRHRHAMRRARDGGGRFLNTKKKIQLPANNNINTTTPSSKGKGCAASEVSSMDSDFSQNYLLNSGHIGSSNATSVEGFQFQGIHNTDNPQLGCHYQWNLNDNHCYCMQSGASNLQPF
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MEQDDEEFEQLLHEIPQATSPDTPNEIPRATSAPPHLEELQRVYGQNVDARDFGLQPDEVPVKPFIDIRCDEQYEDFYKSYSGAKKLPPPMDNRALYNDFPVLSPKASQLSYSLAGLQLDSPRTRHRKHRQLEAQHKQQQVQQQQMFQQREPSPNHHTAAAHHFPNSSSNQMFGEPKMTSAFGNLNFDGSSGRGLQTTSDETGDGLTLSHGANGGNISNSQGPVESNGMYGNMDAFGGVGTVGYGAGSGASLETFTSRSPPPIDLFPRTSSAVEALGNGLYNGISDFSQVSSQAVEKLLRQGSPGLNSYSAPRGGEAYGSAVASSYEQQQQSEVLEAVHAAARGQSASTPGTDFYSPSSQQQILYDKDISSLYEAQRLQAQMAAIRYAQAQAQMEDEKRKQQQRLIIQQHQQQIVDRQNQILLASLQAQQTTGPYGRGGIAPTMSSIHNQVALQKLRQQQMLEGLWAVQGLVPTESSRTTTATSICRYYNQGYCSRGEMCPFLHAPSGGSTRVGHGASASLKEGARSGQLAAVSRDERLPAYPEKILQRRSARASNGGVAVVSVSTGLRRKGDGLSNGHANGYSNGHIALGGAAQLPSPFIGDSQAHRAIQENLEFDSRLSVAHHLQQQQPKYTKLDEVEGRIYLIAKDQHGCRFLQKKFDEGGPEDVQKIFYEIIGHITELMKDPFGNYLVQKLLEVCDESQRMEILRVVTTDGELVKISLNMHGTRAVQKLIETLKSPDQVTMVITALTEGVVELIKDLNGNHVVQRCLQKLSHEDSQFIFDAAAAHCVEIATHRHGCCVMQRCVDFASAPQKQRLVAVIAANALTLSQDPYGNYVVQYILDLKQGWATSEVMLRLEGSYAFLAMQKFSSNVVEKCLKLGVEEHRGRLVRELTASSRLGQLLQDQYANYVIQSALSVCKGPLHAGLVDAIRPYLPALRNSPYGKRILSRTNIKK
The following text describes a protein:
Function:
Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes.
Subcellular Localization:
Basolateral cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Presynaptic cell membrane; Single-pass type II membrane protein.
Sequence:
MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESYVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLEDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVIFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEILDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEADGLSRPQRPRPRKEPGGEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARTLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSVPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVWLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNEPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDTPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA
The following text describes a protein:
Function:
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Sequence:
MDIGIVGLGAMGKNLALNFHRNKFKVAIYNRTHSKAKAVADELKSESLKAYESVSDFVASLVKPRVIVLLVQADAVDSVGEMMAKCMQEDDIIIDSGNSYYKLTEERKVRFHKNFKVHFYGIGISGGEEGALWGPAIMVGGDEESARKRLLPLLEKVCADPQVEGTDGKKCISYCGPGGAGHMVKMVHNGCEYGIMQLISEAIAIFRSVLKFSVEQVADVFALYARTEGCYLFENVAQILYKKEDDKPLIDFVKDVAMQKGTGRWTSIEALNLGVCATIIDAGVAARTFSSSKDRFLMHVEDSTALLKSVFTQGLCKDAIMRSLLAAMLLAFQQSICVIHALSESMQYNTSIFEALCSWRGGCIIRMNLLTPLADFYKQNANKRVPLMHASFVKEKYINRDVVSQLRLLVSSAVKAGLPIPAFSSAMTYLDMIQTEVLPTKYIQGMRDNFGAHTYERIDKEGVFHSVWTEK
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MSRIDSRNLAREFSKAANCTQKAALAWLKSYDYDYPLALACWQEVKEQEVREKKCDKLFDQYASAEDKSTIDLDNSLQLFEDLGLSLEDPATLLVSYLFQSENMGEFHRDAFVKSCLSLHVCNMEQLKSRVSEKKEEWSSNAELAKAVYRYTYPLACERGQRTLPTSIAIEFLQLLLKDSFPLLSEFVAFLEQSPVANKTLPKDTWNQLWEFAAFVRSCPDCSQYDFEGAWPVLIDEFVTYFKNKS
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MMTTFFPRRLVPRTSGIQYQTRHFGAAGFGADMAKSKNHTTHSQSRKWHRKGIKKPRSQRCESLKGMDPKFLRNMRFAKKHKTVLKKMQANNAKCTCQGCQGPRKAQGSQAQNPKGGQPQAQFTYLHYSPQARETCSRPYCQGSQALPANGQGQGTNQGPGCGCNCGSGSGSCSQRCPGPHEGCQVETSVCQCEGGRTGVTPGWCPPALFVQINLRQDLSKEKKEKETLPFLGFL
The following text describes a protein:
Function:
Has deoxynucleoside triphosphate (dNTPase) activity. dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (By similarity). Phosphorylation acts as a switch to control dNTPase-dependent and -independent functions (By similarity).
Miscellaneous:
MISCELLANEOUS: Does not hydrolyze dGMP and dGDP. Shows significantly reduced capability to hydrolyze the chain terminator triphosphates ddGTP, ddITP, ddTTP or 3'-azido-3'-deoxythymidine (AZT), in the presence of dGTP activator. Able to hydrolyze an anti-cancer agent, araCTP.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MDSGQPWFPKIHTKEVRRRLSSLNIATPSSSPCNMNWQSLEPKHIINDNVYGTVKVPRPIDKLIDTVEFQRLRHLKQTGLVYLVYPNCEHSRFVHSLGTFSLAYALVDKLRHSQPSLNITESDLICTSVAALLHDVGHGPFSHLFDGEFAKRNGSRFKHEDMSILIIKKIMNKPEIKSEFACILGETDEEYAKSVTLITELISGKPFDFQDMDGFKDLPADVREETVKNEWAIIGCGPEKSFLFDVVSNSYNGHDVDKMDYLLRDSKASGVGITFSESTLERLFNHVRVVIDPNSGLKRIAYSIKCIGDLKAIGDSRQELHSKVYQHKAVRFMETLMVDALINAGDFLKYKGSNGELYSLKNVTEDVDAFLKTTDYVEQEILNSQITDPKMIEAQTALLKIQRREIGCKLGYFEMNPENATQLKGNCNNQTGAAEVVKKVGQKMKEILEQMDDTEEMDGKLKDIQFTVMHSVLGRGLDDKTHPIERQIFYDGKPSEHEGKQVVGFYPSEDYVINNCPRMATKWEIFVMGDRSLRKEPLLADRVKRALQLAGESEKFLTPRKRSPQDSPDEVSSSCSTAKRRLEFGSS
The following text describes a protein:
Function:
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSVCLESSRPRDGLKLPLNRSFSEPGPPTPGHLTLSPPKRCKLDTPSVSLPTSPCAESATLQRALVLKKVKTLDPDGLKVKLEAARHGPKSFIVLDCRPFISYNVNHINGAININCSDRFNRRRLQQGKATLADLATTREGKDVLKRRAFKEVIVYDDNTCDKERITTAQPLLLVLSSLVEDNKEPALLIGGHTEFHRKHKDLCEDTLVTGLSSRGLPSSASCPALADIDSHPASRVLPFLYLGNSKNAADLSCLQDLGTTCVLNVTPQLAGYHETCGITYKQIPATDNGHQNLKQYFEEAFEFIEEARNNGLRVLVHCQAGISRSATIAIAYIMKYKQMSMVEAYKLVKACRPIISPNLNFMGQLLELEQSLRSGSNNNNHQCRWSQQSSDEVTQGCSV
The following text describes a protein:
Function:
Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin.
Sequence:
MTKTNNFLPLMLDLSGRKIVIFGGGSVGERKAKLFSGCADTLVASLEFSQALQELGTSGQVRLVQLDLLTASDSELRGLISGAFLVIPATSNFELNQKITAIARENDILINQVDTLGSVVIPSVIKRGDLVIGISTLGHSPAVSKYTRKQIEGLVTPEYSDMIRLQDELRSYLKQHVAEQRERKEILWKVLESETVWNGFSESYEKAAERAYAIISSYLVNSNR
The following text describes a protein:
Function:
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, Cortical granule. Lysosome.
Sequence:
MLCLLKFTPLFLVVAVCHGWLFGDLFEKQKELDEISLWPLPQKYQSSAVAFKLSAASFQIVHAKQSTAGPSCSLLENAFRRYFEYMFGELKRQEKSRKKAFDSDLSELQVWITSADPECDGYPSLRTDESYSLSVDETSAVLKAANVWGALRGLETFSQLVYEDDYGVRNINKTDISDFPRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYHPFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGPVNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIVAATKKGYMVWQEVFDNGVKLKDDTVVEVWKGNDMKEELQNVTGAGFTTILSAPWYLDYISYGQDWQRYYKVEPLDFTGQFLQSNSF
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
Sequence:
MGDRNKQPVILLKVPSSDDFYGSALRSHNLDPIFITPSHFVFKNLKQLQAKLHEPHKYAGIIFASPRCVQAVNEALGKTPLPSCWRALHNYSLGKNTHSAAWITFQNLPTLGDHAVNANNLCDLIVETFGPKRDLPLLMPCGNGVGQTLRLRLVAQGFRVDACEVYESRSHPDFVNQMRHALKFKRMETIVFFGPSSVRSSLEFFGNYNVSLKDRKLIAVGSGTRKAMEESGIKADGVVNAADVDRLINIIKT
The following text describes a protein:
Function:
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
Sequence:
MSMIFNTEYGYLEALTRGFKNGMLKHSDYLNLTQCESLEDVMISIQGTDYGLIFGGEQSAPSVEVIERCLRDRLLQQYYYIRSHSTEPLTTFMEFIRYPFMIDNVALLVAGLNNHRSMKRLLRMCHPLGEFDQLGAIEVASNSAELFDAVLIDTPIARFVPRDLPMESLRYLDVEIVRAHLYRAYLEKFYAYCSQLGGNTANVMTNLLSFEADRRTITIAVNAIGSDIIPKERLKMFPTCGYLPKIALASMSTLNDTDKIRDVCNVFDGYGKMFDNLERDSDGMITLEDRFLMMEAKKNVQTFLQQYHFGIFYSFIKLKQLEVRNIVWISECIAQRQTDRINAFIPIPLD
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Cytoplasm.
Sequence:
MRLLRTDPTRPDPEVIKTAAEVLKNGGIVAAPTETVYGLFTHAYREDGCVKVFKAKGRPMDNPLIVHVDSVEMASEIAEIPEGIRGVLAQLWPGPVTIVVKSRGVVPRCVTAGLNTVAVRAPAHPIPLAIIKELNAPIAGPSANKAGRPSPTTATHILEDLGDEVDLIIDGGPTFFGVESTIIDVTRKPPALLRPGPFTVEELEKFFGEIQIPPVARGLAEAEVALAPGMKYKHYAPDTMLVIVHFDLAEAVKVLKARGLKVAVLCAAGKCADADASLHLGTDLYEVAKNLYKSLRDLDKLSVNIGIIPAVEERGIGLAIMNRIRKAAAHREAFSPEQLLKYI
The following text describes a protein:
Function:
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides (By similarity). Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor (By similarity). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. High concentrations in forebrain structures block splicing inclusion of NRXN1-3 AS4 exons while low concentrations favor their inclusion. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity and is linked to behavioral aspects. Regulates expression of KHDRBS2/SLIM-1 in defined neuron populations in the hippocampus by modifying its alternative splicing resulting in a transcript predicted to undergo nonsense-mediated decay. Can bind FABP9 mRNA. May play a role as a negative regulator of cell growth. Inhibits cell proliferation.
Subcellular Localization:
Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
Domain:
The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase.
Sequence:
MEEKYLPELMAEKDSLDPSFTHALRLVNREIEKFQKGEGKEEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKSTLRTRGVTTPAITRGRGGVTARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSAADYYDYGHGLSEDAYDSYGQEEWTNSRHKAPSARTAKGVYRDQPYGRY