lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acetylates soluble but not nucleosomal H4.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MALKQKGTDAAADPKKRRRVGFSGIDAGVEANECMKVFIARNPDEAGSANSTSLQPFDLNHFFGEDGKIYGYKNLKINVWISAISFHAYADISFEETSDGGKGITDLKPVLQNIFGENLVEKDEFLKTFSKECEYLSNVVTDGNVIKHDASIDEDSAVEIVRVELQGAAAFLYCRLVPLILLLVEGSTPIDITEHGWEMLLVVKKSAQASSSSNFLVLGFAAVHHFYHYPESTRLRISQILVLPPYQGEGHGLRLLETINSISESENIYDVTIEDPSDYLQYIRSSIDCLRLLTFDPIKPALCSMVSSLKDTNLSKRTSSLKMVPPSDLAETVRQKLKINKKQFLRCWEILIYLNLDAEDRKSMDNFRACIYDRIKGEILGTSTGPNGKRLVQMPSNFDEETCFAVYWTQDGGDADDQTVEQQPEDLKTQEQQLNEVVDSQMEEIVEIAKNVTSRGKDKLSVSCSV
The following text describes a protein:
Function:
Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway.
Subcellular Localization:
Nucleus.
Sequence:
MSITKTYNGDPTSLVPTQSVKESLRLIEDLKFFLATAPANWQENQVIRRYYLNHDEGFVSCVYWNNLYFITGTDIVRCIVYKFEHFGRKIIDRKKFEEGIFSDLRNLKCGADAILEPPRSEFLEFLFKNSCLRTQKKQKVFFWFNVPHDKLMADALERDLKKEKMGQRPTTMAHREPALSFHYDESSSLYTQLGKHMETQKRINDAATSSTSNTATTLTDTGVSSGLNNTTSGGGSDSATSTHNNNEASTKPSNGSEKSSPEYTTTARGRDEFGFLNEATPSQYKANSDYEDDFPLDYINQTTQNSEDYITLDANYQAGSYANMIEDNYDSFLDATLFIPPSLGVPTGTAATATTSNQVAFNDEYLIEQAQPIRTPLPPISSSTISGLLQPKSAAKFFSLQSANGGEEFFPAYQNDPSTANAGFVPPISAKYATQFATRQVATPTYIKAIPQTGAAAATGNGGQPQQYYDQATGNAFYPAEIPVSYNVVHPESEYWTNNSGAVATTAAATAPMYDASGFPIPINQSYMVMNEHEMVPYQYMNSNGAMIGMIPPHQQQQQQQQQIAMGYQSMLRQQQQQQQQQQQQQPSSTMTKKKKQIHSFNNNKSLSSNGGGITKKSHDNNNHSKVKTSYGSLNDVVNSKVTKVINKEEVKQSQT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MISMMETSTTEKKSNTDNSILKKIIIDSWRQRLSPIEWSLKLYNGFYNNNNNNNSNNNNNNNNNNNNNNVDNNEINSIELCEILLDLMNIGQSPSPLLVSYLRYAISIKLIGYNEFFESVYKFSSISRAQHFSVILDILFDVINIINYPSHHQNIFNSDNIENSNNNNNNNNNNNNNNSNNNIGFKVSSLSSSLKRNNSKIISTPIVTLLSSPSPSSSSSSSTSPSSQQPQPPQPQPLSYTSPIKKTVLIKNPDSTDSDEIMKVKEEPIKFKTTTTTTSTTTTTSTTSTTTNEISSSPPTNGNGEETTITTKTEDSNGINGIDSEDHKGENGKASPQMNGVHPGSDGNISHKRKEMDSNTIFDDDDSNGVDQHCSNKKMKHTDTLTQPQPKQIQNPQQQEQQQQQQENIEQNQHGNLHLHQPSQQQQQQQQQTSQPSLTTTTASAVTQTTTTASTINKSTKATTKKNYHKQLLSFTRLATLLFKVIEYYFQEDERINNINKSVNNNNNNNNNNNNNNNNNNNNNYNNNNNDSMDQNSNNPAVKYNSNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNILYKNSVKSLEILSIIQNNSTFKTLIYLAKYEFTLSSFKDLVLPFLAIQNSIRDNIVKQNIPSTQLISSQVKGQEFASQQTQLLNPLFQLIKQKYQKLFIDFRRILINKQEILPNHDIGSLVHGSSQSDKQIILSFEIIIDQEINGNHFKSSHTKLAISRGKPNELDTILNLKNNKNNNNNNNNSNGNGNGIDIGSSTDGSNKLSSTNIEEGNNNNNSSTHLNGNDQSQQSLDDEEPKQSQQQQLPPPSPPQQSHQKIQIQKQLQLIRQAKNLENVSDCFFKLLTLKTVKGLSDVEFLLEIVKILFQKLVRCNPNSNEYKKTRLFLLFKIPHFYSLMIDNYGNNNNNNNTNTNNINNNKNKNSKKSNNKNKNNKNNNKKNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGESSDKNEINPEGSIGSNNNNDNDNNDETNTNTSSNNNNNNNNSNDNENVTDNNKNNNSNTKNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKKNKDLNLHGNIIENVLYQINQFPSLYNVEDNIILSLIQILIKKHLVDINLLKSLFPNYHTDIDSIDSEIQSPPSSELSFDNLFDIHSIADIVKIKELIESLLNNSDPNNVSIMKRLFDFIKNHLINSFDYQDKLLNVLFNAKNIDYDSNKLLIAVIMYIFSDPLVIDTIDVHGYTLRLVMILIDVCESYGSSTTATTTEDIDIFKNENDNHDQKHLYFYFTIPFNLLYTLLIILYDVKNNKYNLDLIKSKLSESLNNKNNSRKSKSNNSSNNSINNINNNNNNNNNNNNNNNNNNNNNNNNNNFIQWIYNMIKDTNFSNGNGVNNVSTSFEFQFLKNLFDSDLGEDSIEKFQNFSQREYSSWDIVSKLPNVLYNIFDCYDRNIIQEEKVTQTMQLLFQYIPFSPIIVFDYLSKTKSSFFNVSPSSSTTTTTTTTSTTTTITTTTTNSSAYSTTTTTSASTSLPKSTDGKLLNGKSSNTSTTTTKNNGDTPTITTVITTMSSKNDKPLSLVEACLTNLNENRLLFRLSDYYKSLISEDHLNDLYKLFDPISETINLLLLSPKLQKFNELGYYSNQSTLFNSICLTNLSPPNQLSNMTPANAIRQVIDQFLTKSVSPNLSNLERDIKYIHMRLSNDLCQIVNLVSLEILDIILQSCQIESLYSIRAMELGGYILGGLIGIESLPILLNSIIPSWSEHIQTSLHGQLLSYFCFSSIVNSNALYYIQTDLCIQQSFKKFFLLLNDTMKRILSVAPLNGLITFCLSTITLFIHLNHSSITTYLYNSSSNTQLINQLYEIISKNQSLKKKQKLKQKKQQHNNNNGGEYNIDQDHIEQIQQQQQQYQKQQQQRKDEPNYEKLEEFIKTQYQRNNHSKLKSIFNILSISQLEDLSMSILNLSNFFLAISIFEDKNDLQYCSKLFN
The following text describes a protein:
Function:
Involved in protein export.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDISKLLKDRKILILIIFVTLSVFLIVFKGLDFGIDLSGGTIIVLKAEKPMSDKEIEATIKIITERLNYNGLNDVVIYPRGNDEIIVEIPKSCDTDRIIKILKQQGVFVAKIDNITAYTGSDVQNVELPTKIPQGETWAYGVPFELTLEGAKKFAEVAKGKAYHKVELYMDGKLISAPVLSPDLADGKPHPQQVITVGAYPPTKEEIDEAMAIYSALKSGALPVKLDIEYISTISPEFGKEFLKGTAIALLLAFIAVGIIVSIRYKQPKIAIPILITCISEVIIILGFASLIDWKLDLPSIAGIIAAVGTGVDNQIVITDEALKRGAGKIRASIKRAFFIIFASAATSIAAMLPLFVLGVGMLKGFAITTIAGVLIGIFITRPAFARIIEEMFKKF
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE5. Probably an endoribonuclease (By similarity).
Sequence:
MTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVAVLVNRLGRLADIRMRAICTALEVAVDCSR
The following text describes a protein:
Function:
Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).
Subcellular Localization:
Nucleus.
Sequence:
MSEKEVTIDEDLNVDDELNEFDDGEEAPVDNAMLFGSQPPEDRAGADPKHRKLFEIPEFTRKDKTVNELLDLMTDNPPIIPDAVIDYYLTKNGFECTDVRVKRLLALATQKFVSDIAADAYEYSRIRSSIAVHNSNNGQARARQLMLGQQQPGTQQISQQQHQQNEKTNANKVTLTVNDLSSAVAEYGLNISRPDFYR
The following text describes a protein:
Function:
Component of the histidine biosynthesis pathway that catalyzes the isomerization of 5'-ProFAR (pro-phosphoribosyl formimino-5-aminoimidazole-4-carboxamide ribonucleotide, referred as 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide) to PrFAR (phosphoribulosyl formimino-5-aminoimidazole-4-carboxamide ribonucleotide, referred as 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MRSPASTPSIRGGAFASSPILRHNHLPFLRLNPPSSSPTRSSPPSIQCSVQFRPCIDIHKGKVKQIVGSTLKDLKDDDGSDPITNFESDKSAAEYATLYKQDGLKGGHVIMLGADPFSKAASLEALHAYPGGLQVGGGINSDNCLSYIEEGASHVIVTSYVFNNGQMDLERLKDLVRIVGKERLVLDLSCRKKEGKYAIVTDRWQKFSDVSLDAKVMEFLANFADEFLVHGVDVEGKKLGIDEELVALLGKHSPIPVTYAGGVTVMDDLERIRTAGMDNVDVTVGSALDIFGGNLAYKDVVAWHNQQKVSVA
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Sequence:
MAISDSPQRADLWLINTCTVKAPTMGTLIRKGKAASIPLVDSWMRSSGFKRSRSCQRHRSAVNTAGETLKGHEARLLRRDALPSLDLPKVRKNKFVEIIPINVGCLGACTYCKTKHARGHLGSYTVDTPVQRLKTVVSEGRDIGANIPALLRALVAVLPHRQKYNAPNLHLTASGGNGCHPCVYSFLHVLVQSGRDSVLEGMKREYTFSEFRKIVDTLTRLVPEIHIATDIICGFPGETSEDFDRIMELIRECTFPQVHISQFYPRPGTPAALMKRVPTLEVKKRSRSLTSLFESFTPYAGMEKTYRVWVTNTAADGIHLVGLCTSSTSSCTGPSWKQMVCDWRVANQIPLLETMLRKSDASSGSEAAGSVVTLVAFFTHSRRKQAQGRVCATLAQTRLGAIGSSNQSPISAIPDETVCGRNSSAQVKPTYQDGWCISTARYCRLEALAFYISQTDTHFLSASLLPKLHSRLNLYDLEGRYISWVKVCLHCSDLNYAVRRFNSSNAQPLSCQKFLSPSTWFLAMERKLLQQQQQPPMQAAPATATARGLPTPAAAAAAAPAGQPAVPRPASSDRHSEHLGQHSPPKAPALWLVVAQPVSTASRPAAAQQHHPEAATTKGSPKMLRGLLPAVESTRTTQTSPQSCYDPPESAVGDTIATAIANARLCFSSILSTVRSPDPTVHVVQA
The following text describes a protein:
Function:
Probable inactive allele of Nlrp1b, which lacks a CARD domain, suggesting that it is not able to form an inflammasome. Contrary to Nlrp1b allele 1, allele 4 is not activated by B.anthracis lethal toxin and no other activation signal is reported.
Miscellaneous:
MISCELLANEOUS: Three tandem Nrlp1 paralogs, Nrlp1a, Nrlp1b and Nrlp1c, have been identified. Nlrp1c is predicted to be a pseudogene; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytosol.
Domain:
Contrary to Nlrp1b alleles 1, 2, 3 and 5, allele 4 is missing a CARD domain, which has been shown in other alleles to be involved in the interaction with CASP1 and CASP4/CASP11. It is thus unclear if this allele is able to promote inflammasome assembly; The FIIND (domain with function to find) region may be involved in homomerization, but not in CASP1-binding. In allele 4, the FIIND region is truncated and hence does not contain the activating cleavage reported for allele 1. Consequently, it may not undergo autocatalytic cleavage in this region.
Sequence:
MEESPPKQKSNTKVAQHEGQQDLNTTRHMNVELKHRPKLERHLKLGMIPVVYMKQREEILYPAQSLKEENLIQNFTSLPLLQKLCPKDPENMVRKSWASCIPEEGGHMINIQDLFGPNIGTQKEPQLVIIEGAAGIGKSTLARLVKRAWKEGQLYRDHFQHVFFFSCRELAQCKKLSLAELIAQGQEVPTAPINQILSHPEKLLFILDGIDEPAWVLADQNPELCLHWSQRQPVHTLLGSLLGKSILPEAFFLLTTRTTALQKFIPSLPMPCQVEVLGFSGIEWENYFYKYFANQRHAITAFMMVESNPVLLTLCEVPWVCWLVCTCLKKQMKQGRVLSLKSQTTTALCLKYLSLTIPDKHRRTQVKALCSLAAEGIWKRRTLFSESDLCKQGLDEDAVATFLKTGVLQKQASSLSYSFAHLCLQEFFAAISCILEDSEERHGNMEMDRIVETLVERYGRQNLFEAPTVRFLFGLLGKEGVKGMEKLFSCSLPGKTKLKLLWHILGKSQPHQPPCLGLLHCLYENQDMELLTHVMHDLQGTIVPGPNDIAHTVLQTNVKQLVVQTDMELMVATFCIQFYCHVRTLQLNMEKQQGYALTSPRMVLYRWTPITNASWEILFYNLKFTRNLEGLDLSGNSLRYSVVQSLCNTLRYPGCQLKTLWLVKCGLTSRYCSLLASVLSAHSSLTELYLQLNDLGDDGVRMLCEGLRNPVCNLSILWLDLSSLSAQVITELRTLEEKNPKLYIRSIWMPHMMVPTENMDEEAILTTFKQQRQESGDKPMEILGTEEDFWGPTGPVATELVDRVRNLYRVQLPMAGSYHCPSTGLHFVVTRAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTEASTFDFKVTHFQEHGSRNAR
The following text describes a protein:
Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).
Sequence:
MWRSGAHLPLRRGRQGRRLSTASALVPLPGGCGAPGGGAAAVLPLSCGAGPHLARPARIRAPFGRSRPALRPALGCCVSIYSRFFFPLLLLIQFSQFLHFSVIKGMLFVSRSLCCRGIGAYQLQTNLLSRSIKLSASDTMAFRHKNTRRIEGLDSNVWVEFTKVAADPSIVNLGQGLPDICPPSYVKEELAKAAAVDRLNQYTRGFGHPSLVKALSQVYERVCGRKIDPLTDILVTVGGYGSLFSTIQALIEEGDEVIIIEPFYDCYEPMVKMAGAKPVFIPLRFKNGGNSASSADWILDPAELASKFNSKTKAIILNTPHNPIGKVFTRGELQVIADLCIKHDTLCISDEVYEWLVYKGNKHIKIATLPGMWERTITIGSAGKTYSVTGWKLGWSIGPQNLIKHLQVVHQNTLYTCPTPLQEALAQALWVDYKRMDDPDCYFYSLPRELESKRDRMAQLLQEVGLTPVIPEGGYFMIVDVSTLNVDLPDVDENQPYDYKFVRWMISSKKLSAIPLSAFCGPETKRQFEKYIRFCFIKKDSTLDAAEVILKNWKKQRA
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MFHSEYEKKLRSPSKSPGSKTNYYNNYSNNNNNTPIPLPLSIFHSTYEDNGSNNNNNNNNNNINLNSNNNNNNSNNSGSNINNNITTPIKSTSTTTTTTTTPITTPTTTTTTTTTTPSYDSYGDRFIPLSIGLESQNNYSFDESSYEYLYCYPSENSYTIDKQRDESHLAYNIVLKNELLGSSLSSNFFDSPSSIYKSSIFNNNNNNNNNNNNNNNNNNNNNNNNHVNNNNNNNNNNNIDTPTNNNNNNNNNNNNNNVNINDTTATTTTTTTTNTNIPTTTTNATNNNNNNSNNTTTTTTTTTNTTNTTNTNTNTNTNNNLININQSPSKKQSLMSATMNNNNSNNNNNNNFGILKYNQKQKSTMSNHLDCSPYSLSLLSDDSQKLLSSPRKPQRKISKTPIKILDAPMIKDDFYLNLIDWSSHNILAVGLDTSVYLWNATTSQVSKLCEMESGQPVSSVGWIQRGGIHLAIGGTDGVVSIWDVNKKKKIRELQGHNTRVNALAWNNHILSSGGKDKVILHHDVRDCSNNYTNRLVGHRHEICGLKWSPDGQQLASGGNDNLLNVWDHSMTQQPQQQHQPPPPPPSSNTSSISQQQQQQNTSKPLYQFKFHYAAVKAIAWSPHQRGLLASGGGTHDKCIRFWNTTTGQSIQSIDTGSQVCNLAWSKNINELVSTHGYSQNQITVWNYPTMTPVTTLTGHTMRVLYLAVSPDGQTVCTGAGDNSLRFWNLFPSNKESSFSSNLDSFYNKKGLDIR
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAKGASQSQSSSTASRTSGDAPRGSAAASAGMRRRRGGGGSAGLGGGKGGGGVGGGGGSSNMLRFYTDDAPGLKMTPTVVLVMSLLFIGFVTTLHVFGKVYRYKSAANGEA
The following text describes a protein:
Function:
Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15.
Subcellular Localization:
Nucleus.
Sequence:
MDINPPPSTAPSSPRRSIQRISDAKNKALTFNRRRLGLIKKAHELSVLCDAKVVVMIFDSKNACHVYSSEEPEEQRDALLQKFLNKDFVTVDPLRNINPNIPSDESLHNWRPKDKRIASVTTYSAQPSNNCSSATDSENDFQSFTIKSSTTYHTTPTTASENKKIESITIPDHASVYNDLPLSPTVKHSFVSPVSGDYSDSPLEPSSSSSFSVPPESLNPTLSFQHNDVPQTDNFIPFLTPKRQAYGQSSSRADRSSVRRSQSFKNRRNGKPRISRLHTSHASIDGLTDFIQSPSSGYLDPSSTPITPLDSAINQITPPFLPDNLGQENRGELYSHDNPTSMVYEHPKFDELPNGFIDTHELNILSRSFTASPNQILRESNMVNQDSFTDNPVDATWDALIGTTQIDLDLDYERSSIPSSTIPADQLKDGVPTNSVYRNNMVDHNLYPSLNIERNAP
The following text describes a protein:
Function:
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MPLNMNKYLTDAYTGGIIKKYPEDFIVEEITPEGIILEVGKSIEFKDEENWKGNYIHFTLEKRNWTTLDAIREIANRVGKQRKHFGFAGNKDKYAVTTQRVGCFNVKLEDLMKVKIKGIILRDFQKTNRKIRLGDLWGNRFTIRVREPELKGKELEEALNKLCKLKYFLNYYGVQRFGTTRPITHIVGRFIIERDWEGAFHAYCGTPLPYDDKKSKLARELVDEENFKEAYKKFPKAFFYERRMIKAYIETGSYQKAFMILPPYLRCMFINAYQSYLFNEIINRRFEYGFEPMEGDILIDNVPSGALFGYKTRFASGIQGEIEREIYERENLSPEDFKIGEFGSFIGDRRAMIGKIYNMKYWIEDDSYVLQFCLKKGNYATSVLREFIEKKD
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MYHCSSLGNDLGSLPNYYILIHSPFIPLITPFPSRSHTTAPTIAGAILGLIFFLPLIILSSPVWVPAGTLVFIVTAGFLSVCGFGVALVAALSWMYRYFRGLHPPGSDRVDYARTRIYDTASHVKDYARDYRGYLQSKVKDAAPGA
The following text describes a protein:
Function:
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Sequence:
MGFRCATALGLPLQLRLSLCLLQTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDAEFGGECPADPLPCEELCDGDASCPQGHKCCSTGCGHTCLGDIEGGRGGDCPKVLVGLCIVGCVMDENCQAGEKCCKSGCGRFCVPPVLPRKLTVNPNWTVRSDSELGEYSPLSSTITDNCYVQSTGLGTGKGTSEGQEKSSWRERNYVPDENPHANSTGLHLFPGVVNLCPR
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MELLPQGKQNTVQVLYEDQQRINEFSKLVMRKDALEAELRSQRQEKEYVDDAALEIELVDEDAALQYKIGDVFVLMRQEEVAAQLERDQAAADARIRQLEEEEEHVDARMRALKQVLYAKFGDSINLER
The following text describes a protein:
Function:
[Isoform 2]: A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Subcellular Localization:
[Isoform 2]: Mitochondrion membrane; Peripheral membrane protein.
Sequence:
MQTSAMALLARILRAGLRPAPERGGLLGGGAPRRPQPAGARLPAGARAEDKGAGRPGSPPGGGRAEGPRSLAAMPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK
The following text describes a protein:
Function:
Displays aminopeptidase activity with a broad substrate specificity. Preferentially, cleaves after Leu and Met, but also cleaves after Ala and Arg. Low activity towards Lys, Phe, Tyr, Trp, Gln, Ser and Gly and negligible activity towards Glu, Asp, Pro, Ile, Thr, Val, His and Asn. Has dipeptidase activity. Plays a role in the terminal stages of host hemoglobin digestion by cleaving the N-terminal residue of small hemoglobin-derived oligopeptides.
Miscellaneous:
MISCELLANEOUS: May have an additional translation initiation. Translation initiation at the first Met codon would generate a form that contains the signal peptide, enters the endomembrane system, and ultimately reaches the food vacuole. Initiation of translation at an internal Met codon would result in a form that lacks the signal peptide, thereby re-directing the protein to the cytosol (Probable). A nuclear localization signal would then lead to nuclear import (Probable).
Subcellular Localization:
[Aminopeptidase N]: Parasitophorous vacuole membrane; Peripheral membrane protein. Note=In trophozoites, partially localizes to the parasitophorous vacuole membrane; [p120 form]: Nucleus; [p96 form]: Cytoplasm; [p68 form]: Cytoplasm. Vacuole lumen. Note=In trophozoites, partially localizes to the digestive (or food) vacuole, an acidic vacuole where host hemoglobin is digested; Cytoplasm. Note=In trophozoite and schizonts, localizes to the cytoplasm. In trophozoites, also localizes around the digestive vacuole. In schizonts, also localizes to discrete vesicle-like structures and in released merozoites localizes to a single discrete structure. In ruptured schizonts, localizes around the digestive vacuole.
Sequence:
MKLTKGCAYKYIIFTVLILANILYDNKKRCMIKKNLRISSCGIISRLLKSNSNYNSFNKNYNFTSAISELQFSNFWNLDILQKDIFSNIHNNKNKPQSYIIHKRLMSEKGDNNNNNHQNNNGNDNKKRLGSVVNNEENTCSDKRMKPFEEGHGITQVDKMNNNSDHLQQNGVMNLNSNNVENNNNNNSVVVKKNEPKIHYRKDYKPSGFIINNVTLNINIHDNETIVRSVLDMDISKHNVGEDLVFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVIIHPETNYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTADKEKYPVLLSNGDKVNEFEIPGGRHGARFNDPHLKPCYLFAVVAGDLKHLSATYITKYTKKKVELYVFSEEKYVSKLQWALECLKKSMAFDEDYFGLEYDLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKKNSIDFSYARILTVVGHEYFHNYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTRLSHVDLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGEEYYKKGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWFSQSGTPHVSFKYNYDAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLINPENGKEMISQTTLELTKESDTFVFNNIAVKPIPSLFRGFSAPVYIEDNLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNYNEFLKAKNEKLESFNLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNLDTDVLADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRTLRNTLLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELYDKTYKLSKDDELLLQEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDIRAVYLPFTNNLRRFHDISGKGYKLIAEVITKTDKFNPMVATQLCEPFKLWNKLDTKRQELMLNEMNTMLQEPNISNNLKEYLLRLTNKL
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor vps10. Required to form proper forespore membranes.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MNGINTANEEITRSLEESLNICKQSSRLMQRNLQTGRLMDAFRNCSISLVEMRNSALTPKQYYELYMFNMESLRLLGGTLLETHLNGTHNLMDLYELVQYAGSIVPRLYLMITVGSAYLETPNALVREIMNDLLDMCRGVQHPLRGLFLRHYLLTQTRKGLPLGSEDEEDASRKGTVLDSVKFLVINFTEMNKLWVRIQHLGPIKEFSKRTQERNELKVLVGLNLVRLSQLNLDIDTYRDHVLPAIIEQIIECRDSLAQEYLVEVICQAFSDNMHLQTLDTYFGTVIKLSPSVNVTQLVVAMLNRLTDYVQREYESDSSNEDESETVTEKLGDIKINEEVQQKDEQECPGDKVIPPEYAIQEVLWSHVVEVIQSRSGLPLDCIVSILSSILNFFLRCYPYKPQYADRVFQYINEHIINQPSLRSALHERPLQKSLCAILLLPLTYFPSFSYCLELQNFLPVFNAQDPNLRYDIARMIVQKIIEKGHSLSELTEAQELLGFVSVIIEKKGVDSLDDLQNVALMVHYLNNDDPQIQIEILRSLKDTFIKAGENVKYLLPVVVNRCIFLARNFRIFKCMDWAEKVRLLWEFVNTCINVLYKNGDSLELCLALYLSAAEMADQENYPDFAYEFFTQAFSIYEESVLDSELQYQQLLMIIGKLQKTRNFSVDDYDTLITKCTLYASKLLKKPDQCCGIYLASHLWWQVASGEDSRPFQDPKRVLECLQKSLKIADACMDQLTSLKLFINILERYFYYYDQHCESIIAKHISGLIDLTEQNMRSILISSPADLIASDPRAYASSIWEVANVSVIDSLKNHLERATAYAEKRSEDERWSSIFQ
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. Negative regulator of seed germination and young seedling growth.
Subcellular Localization:
Nucleus.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MDQQPERREGRSFPERKGQKRKLEEGAAAVEDREISAVSTDGGQALLSEVAAQVSVLNSAFSWQESDRAAAKRATQVLAELAKNEDLVNVIVDGGAVPALMTHLQAPPYNDGDLAEKPYEHEVEKGSAFALGLLAIKPEYQKLIVDKGALPHLVNLLKRNKDGSSSRAVNSVIRRAADAITNLAHENSSIKTRVRVEGGIPPLVELLEFSDSKVQRAAAGALRTLAFKNDDNKNQIVECNALPTLILMLGSEDAAIHYEAVGVIGNLVHSSPHIKKEVLTAGALQPVIGLLSSCCPESQREAALLLGQFASTDSDCKVHIVQRGAVRPLIEMLQSPDVQLKEMSAFALGRLAQDAHNQAGIAHSGGLGPLLKLLDSRNGSLQHNAAFALYGLADNEDNVSDFIRVGGIQKLQDGEFIVQATKDCVSKTLKRLEEKIHGRVLRHLLYLMRISEKSIQRRVALALAHLCSPEDQRTIFIDDNGLELLLGLLGSLNTKQQLDGAAALYKLANKSMALSPVDAAPPSPTQRVYLGEQYVNNATLSDVTFLVEGRTFYAHRICLLASSDAFRAMFDGGYREKDARDIEIPNIKWEVFELMMRFIYTGSVDITNEISKDLLRAADQYLLEGLKRLCEYTIAQDITLESIGDMYELSEAFHAMSLRQACIMFILEHFDKLSSMPWQNELVQRTIPEIREYFCRALTKSTTNLQSLRL