lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium across a membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQKSQNVTAVTETNGVAAALGGHHTSPDTNAGKTKDAKEFGCSLGDLRGLMEARGAEAIVRLSTEHEGVEGLCKKLKTDSLVGLNGEQADLDRRRHVYGANTIPPAKSKGFVRLVLDACKDPTLVILVLSGFINLALSFYEPTSAAEDATQHLVNATTAAILANGTFMSTTEAPSEGHGTAWIEGVAILLCVIVVVLVTAVNDYSKERQFRSLQEKIETGQKFSVIRNGEAIDVPVSDLVVGDIARVKYGDLLPADGFLIQSNDLKIDESSLTGESDHIKKSIESDPVLLSGTYAMEGSGKMLITAVGVNSQTGIIMTLLGAGKAGIGDDDSTSTSSSSSSSSSSSGSSSNGSSDSSKSGDDDLTAKSVLQAKLSKLALQIIYCGTTIAIIALIVLVTRFCLDHYVFEKNEFSLVDIQMFVKFFIIAVTILVISIPEGLPLAIALALTYSVRKMMHDNNLVRHLDACETMGNATSICSDKTGTLTTNRMTVVQSYINGNHYTSQEAQPHGANLPGSTGPILMEAISVNCAYNSMIVEPTKAGEQIQQLGNKTECGLLGFVNRLGGDYAAIRKKFPEHDLTKVYTFNSSRKCMMTVVPYAENGQNIGYRVYCKGASEIVLGRCTYLIGSDGKPHQLTGDRLKEITSTIIHEMANSGLRTICVAYKTIIKKGTRDVEKTEIEFAEDSDIDWDDEDAMYQNFTGIAICGIQDPVRPEVPVAISKCKKAGITVRMVTGDNIMTARAIAMSCKILEPGEDFLALEGKEFNERIRDENGKVSQAKLDEIWPRLRVLARAQPADKYTLVKGIIDSKATPQREIVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVITAFVGAVTVSDSPLKAVHMLWINLIMDTLASLALATEQPTDELLERKPYGRKKSLISRTMVKNILCHALYQLIIIFVIFFYGDTIFGIKTGLYAPLFAPPSQHFTLVFNAFVMMTVFNEINARKVHGERNVFKGLASNRVFCVIWVTTFIAQIIIVQFGGAWFSTAPLTLQQWIVCLVLGFSTLIWGQIVATIPSKKLPKAWKVGKGEVQPANLHINGDYNVRARSRAVTLRRSGKSLWVRGMFIIGNHLRVLRAFGMEKSEKAAFGRTAPAMTAEAAERWRASYRKYRHQKHQEKKATAETAESVKSADWAKEQKEKKKTFKQIKQVARGKSLDKDSKKHHKKRKDQTNVDMEDIELN
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MRAPFCLLLIVGVLLLLRWPASSLASVQVARTITVDQRGGGDYTTVQSAVDAVPDGNSQWVKIYVKQGSYREKVIIPSDKGFILLEGDGSSSTDINFDSHVDGADAPGIAPITGRLRGNLAEISQTYNSSTFTVHSDNFVARNITFKNTYTGNNPAVAFLMDGDKGAFYDCAFHGYQDTLSDLAGRHYFRRCLVEGAVDFIFGYGRSIYQDCTLVSNMAASSQQPGWVTAHGRAADKSAAFVFKGGSITGSGRQYLGRAWNEQATVVFYQVNMASIVVPQGWAKWTSTQHVSQVTFAEVGCSGPGSATGGRVPWEKHMDNAEVQRFVDIGFIDDGWLSNQP
The following text describes a protein:
Function:
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Associates with chromatin.
Sequence:
MENAKDFIGETIKENGLLTIEDDGSSSSDEEATLKRRLAGPSVLKSGQENVNQKKINEIIYEASKGSKFFEAEQKRDRELRLRIEKVQVEVEKYQSKLRFDKAFQREWTIRQESVDTTVEDFRAKRDLTQIIVHVDCDAFYASIEELKNPKLKSLPMAVGKSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQNVLAQYDSNLCPASIDEFYMNLTSHLRLQELAFTVENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQFFIPFDEIGISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLVILSYIFLPKSFQNLLRCSYGFGTTILDEYGESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKPALQLLRQSYPMTIRLLGVRATKLVSKSRCLAMQLKFQSQNTVPCPVCQKNIENELGILNQHVDLCLNVETVKSLINTDHTANPTIKKRKSNTLDTYFLE
The following text describes a protein:
Function:
Iron-storage protein.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEESMFETHINYLTRIGDDSNALYLYEKELGARTFDEE
The following text describes a protein:
Function:
Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1.
Sequence:
MSSPNNQPLSCSLRQLSISPTAPPGDVGTPGSLLSLSSSSSSNTDSSGSSLGSLSLNSNSSGSDNDSKVSSPSREIPSDPPLPRAVPTVRLGRSTSSRSRNSLNLDMKDPSEKPRRSLPTAAGQNNIGSPPTPPGPFPGGLSTDIQEKLKAFHASRSKSMPEVVNKISSPTTPIVGMGQRGSYPLPNSQLAGRLSNSPVKSPNMPESGLAKSLAAARNPLLNRPTSFNRQTRIRRAPPGKLDLSNSNPTSPVSPSSMASRRGLNIPPTLKQAVSETPFSTFSDILDAKSGTLNFKNKAVLNSEGVNFSSGSSFRINMSEIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELDILHKAVSPYIVDFYGAFFVEGSVFICMEYMDAGSMDKLYAGGIKDEGVLARTAYAVVQGLKTLKEEHNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISKTNIGCQSYMAPERIRVGGPTNGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPPSLPDSFSPEARDFVNKCLNKNPSLRPDYHELANHPWLLKYQNADVDMASWAKGALKEKGEKRS
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.
Sequence:
MMVLQSVPDGFGEAVTYLNSMPQDVVAEVCQEVLAFLSYKKGSLEVAPFIAKLEAAGVEASIESVRGSANALSYLFRSAAKAKISADELSKELSSSLAWSDSNIAVIKHIWNQQGRTLMSPELADYVLGVGKLVDLKWKLGVAMSSNNCRNLNSPFVTISLKVADPSGQVQERSFEMTVPQFRNFSKQLKAMAAVLETV
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion.
Sequence:
MSQISMFVRKLHKFSYNPNYKFKCGLEIHTQLKTKYKLFSLSPTSYNEPPNTKLSYFDVGLPGTQPLLNPEALLLALKASVALNCDIQSYSSFDRKHYFYADQPLGYQITQHYYPLAKNGYVQLNKFDDMPDKVISLEQVQLEQDTGKTVNYDDRINVDLNRANTPLIEVVTKPDFENIDQVQAFVRKYQLLVSHLDICTGDLETGAIRVDANISVNNNPRVEIKNLGSSGEIVDALKYEYNRQVTLLQNNGKIIQETRGWNGIATESLRKKENAVDYRYVPDSELPVIRLDKNIQAQLQNTLDELPDSVLDRLTKEPYNLQLAHARNLLFQPEILDYYENIFGRIRDANKWFFHELLAAFAKSDVEFQVDIVLPDMLVDIVSSVEKNEISLTGARIILKHIIRNKSTKTLPQLIKELDIGKPEASAELEEAINEICQQIINTNADVVEKIARGHTNALQVLIGQAMKATKGKVHAKEFRSKFMELLK
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKNITRLSEFNDLIVDGNGDFKLFSIDQQSNVVYFITENNQLIIYSPSTKKVSMRIELDEQDILSEGAKVISIQFIPDLDAVCMASNKGDILMYSTSNGELECVGIIGSGITCMSWSPDYELFILATESETLIQMTKDWEMINEVSINSYLPGKPKTATTTTNNNNSKNINKIPIITWRGDGQYFACSSYEEDIGKIQLRIWERSLQLHSMNESDVTGLENQISWRPNGSMIAVSQRLEQTRHDISFFERNGLKHGEFTLRSKGEIQSIQWSSDSEILGIQLYLEDEKRSVLQLWHRSNYYWFLKQEIQCGDSNNNNTNERIVNIQWDLSSPIVRVLTQIGRFSEYRLCWDYDVSQGSSENNPTTVVMVDGNQLKLTPFRRLVVPPPMSAYSIELPDRLNCLGFSFNQSTYQLSVMVDQSILIYTPATLPPTPKATLPKIKSANGLLAPLPSDFKANLPNYSIAPTLTSRVVIDRSKLQLHKIRHFLWLNASTFIGVESKTNQNSDSIVEIVFNVSSGELENIYRTSVSTKILRLTHHLQSLDQCLFESIDGYLHLYNCSTSASSGGNLEQPTSISPFIYQENIFKFPTPCPWFSSCTINQEDSVVGLNDRNKLYINQSLLCTDCNSFALHNKFLLFTTVSHVLRSVSLLAPPPTQPLTYVPVSNVIGNYVGHKSQALQQQSNYDDSIRDVERGSRIVAVVPHDTRLVLQMPRGNLEAISPRSLTLATIREMINNHQYLSAFLTMRRNRIDMNFIYDHNPTDFIRHIEEFVDQIQQIDYLNLFISSLRDEDTTKTLFIDLETKHLLPPTNVVKPSSIVVGKVNLVCDSLRKVFMEKDSIKFNLPILTTYVKKSPPELDQVLRLIQSLRGEEINEQGETIVNRLAEESLDYIVFLVDVNKLYDIALGTYDFELVIMVAQKSQKDPKEYIPFLQELQKMEKFYQRYSIDKYLSRWELALYNLSRAGKKYQQDCLDLIISNKIYKEALVNYGGSAADSDDNLIEEKDEMFKKVLNIYGDYLLESNQFEDAAYLFLQANQEKKSINAFRDAGLWENAISQANKLSYTKEQLNQLVIELSEILKRNSKFQQAAQCLEKFQLIDQAIHMYCEGYYFNEALLLSSSSSSSNQEEEQQIKIKKSLLDSLSNQINEINNNFEKYEKMSTRIVIVRTNKLNYVPLLLPRGQGDFETGSMMSGMSGMFSEGGMSVNSALSNVTTSSYVSTYSQQTGTFSTATKTRLKKKDKKQKPQKVRITGKEGSPYEEDYLVDQMKKLIPSSSQQESIGRIIKGLVLLGLFNDARQLSTLYQKYLNLIDSSLDDLSASATAILPENKKEKEREQRLQLEQLEEQQQQQQSQQQQQQQQTSTTSNNKIITLNIKQVVVSRDKPNWNLTIF
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MISYSLPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKLDPKVKQAIDTAYEQLKAFHEMLVPPNIGGGYQGISFGVIWRSIEKIGIYVPSGKYSYPSTLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYVAIKLGVNEVYKIGGAQAIAALAFGTESVKKVYKIVGPGNVYVQAAKYLVSSVVGIDGIEGPTELVIIADETAKAEYVALDMKAQAEHGPDTYIVLLSNDDELIRRVEEKIKNDKKIYYIIKTKNLDEAIEIANKIAPEHLSLYVKDAYTLMDKIVNAGAISLGNTPPAIIDYVAGPNHILPTNGWAKIRGGITVYDFIKPTMYANVRDINKQLLEASISLANYEGFIIHGKSIGARYE
The following text describes a protein:
Function:
Binds ubiquitin in vitro. Might contribute to the loading of the ESCRT machinery (Probable).
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MDKLKIAEWGEKLKTGGAQMSRMVSEKVKDMLQAPTLESKMVDEATLETLEEPNWGMNMRICAQINNDEFNGTEIVRAIKRKISGKSPVSQRLSLELLEACAMNCEKVFSEVASEKVLDEMVWLIKNGEADSENRKRAFQLIRAWGQSQDLTYLPVFHQTYMSLEGENGLHARGEENSMPGQSSLESLMQRPVPVPPPGSYPVPNQEQALGDDDGLDYNFGNLSIKDKKEQIEITRNSLELLSSMLNTEGKPNHTEDDLTVSLMEKCKQSQPLIQMIIESTTDDEGVLFEALHLNDELQQVLSSYKKPDETEKKASIVEQESSGSKDTGPKPTEQEEQEPVKKTGADDDKKHSEASGSSNKTVKEEKQAVKIELGLSSDEDEK
The following text describes a protein:
Function:
Possible function in sperm maturation.
Subcellular Localization:
Secreted.
Sequence:
MTSSLKIWGILLALLCILCRLCVYSNNIYWREFIKLHYLSPSREFKEYKCDVLMREKEALKGKSFHMFIYSLWFKIQRACINEKGSDRYRNAYVWAPGALKVLECHWEKYNNRYTESRSFSYIEFHCGVDGYVDNIEDLRIIEPISN
The following text describes a protein:
Function:
Nonessential protein which may be part of a two-component regulatory system activated by changes in the extracellular environment.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRVPIAVQLGLLVLLTALAGLAALAIATWINNYNFVVDVKSQSLQLVASIKSSQITSNLDLLETTSKTIITRILIQSALQRYYAGNTTEENFASSITDVQSALGSRGYLSLYQASIYARNVENGESKARRLLNVTSDEVPEIRLPYDHPNGTAVMLGDEGLGYPPSLYPNLTEDATTNKLYAFDGVPITTNQPLLLGPLATNDSFSLISLSLPIINNTSAADILGYITVVASAANLQDAMSSRQGLGSSGQVLLLAPSRPENRFPTGSRPATATSEPQIAGLDNQEVRYVFRPTPLPGNKRRHSPAVASGASFPLRDYPIALKVLNQPYDSINHSITDLSSKNENGTRVAVGAIQQRSDLVEWVLIIEETHGEAFAPVSRLRKIILACVFGTAGVIALLIPPLAHLSVAPIRRLREATRKSVNPTIGPLSPSLSTMVDPIEISMHNGNEKSEKGGFFNRLKRGRGNLATGHDRDNEPHQFQIPGRVKERKHIITDELTDLTKTFNEMSDELVIQYNRLEERVAERTRELEKAKIAAETANESKTLFIANISHELKTPLNGILGMCAVCMGEDDLPRIKRSLQTVYKSGDLLLHLLNDLLTFSRNQIDQAIRLEEKEFKLSDIRSQLQIIFQNQVQEKQISFSIKFCHPDTPPINDTPEVISRAPGPVYGPPGTAKLKDMVLWGDQHRILQILINLVGNSLKFTPEQGTVAIRIKCVGEEKNPSASPRPESRALSRWRSIGSSHASSRPKTSLDRPRDGGDEETTRPPNLRTLILQFEVEDTGPGIPQHLQNRVFEPFVQGDLRLNRKYGGTGLGLSICSQLARLMRGQIQLNSEQGRGTLFLVRIPLGFVKESPPSTASSMTSLAGSRTSSVFSLDDLASVTKAPSNHSVASQHESTKSNAEIQDSQPRLVGLSQPFFAPPVPQAKDNGLKKIRALVAEDNVVNQEVVLRMLALEDVYDVTVVKDGQEAYDTVKANMEEGKVFDLIFMDIQMPNLDGIESTRLIRQMGCSAPIVALSAFSEDSNIKDCMNSGMDMFISKPIRRPALKQVLRRFTPIPEEAEKPQM
The following text describes a protein:
Function:
Together with Xaut_5044, catalyzes the reversible isomerization between pivalyl-CoA and isovaleryl-CoA, using radical chemistry. Does not exhibit isobutyryl-CoA mutase (ICM) activity.
Sequence:
MNQAAVQLPLPGFEQASGQWRSDYSRQVAGEKPVRNRSGIEVQPLYSPRDWAGERYLDDLGFPGQYPFTRGIYPSMHRGRTWTQRQLIGLGTPQDYNVRVRRIIDAGATAISLLPCCSGFRGIDCDEVDPVLLGTCGTVVNTTDHMDAALDGVPLGTISTAMNDPSPFTLLAFTLGVARRRGIDWRSITGTSNQSDYISHFIANHQFYRLSLPGSRRVLLDHIEFCRRALPNWNPLSVVGQHMQQAGATPAETMGFTLSSAIQYAQDCIERGMDVDDVLRRFTFFFDISISFFEEIAKFRAGRRIWARIARERLGAKDPACWRFKFHGQTSGVDLTQQQPLNNIARVSVQAMAGILSGLQSMHTDAYDEAIACPSEETARIAVATQNILRDEAQLCAVIDPLGGSYYVERLTDQMEAEIEAVIARIDAAGGMYKAAEVGLVQTMIGESALAFQEQLETGERKIVGVNCYQVEEDPTIPPAERPDPEAMERHVERFKVFKRERSQDAVARALDALARAANSERENVFEKVVEAAEAGVTHGEMVGCLRRELGFGHPLIIA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate. Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate.
Subcellular Localization:
Lysosome. Secreted.
Sequence:
MLLLWVLVMAASALAVPAPGAGGQRRGAAHAWPDAPNVVLVVSDSFDGRLTFYPGSQVVKLPFIDFMKAHGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVMEKHGYRTQKFGKLDYTSGHHSVSNRVEAWTRDVAFLLRQEGRPMVNLFPKKTKVRVMEKDWRNTDRAVNWLRKEAINYTQPFVLYLGLNLPHPYPSPSSGENFGASTFRTSLYWLKKVSYDAIKIPKWLPLSEMHPIDYYSSYTKNCTGKFTEKEIKNIRAFYYAMCAETDAMLGEIILALRQLDLLQKTIVIYTSDHGELAMEHRQFYKMSMYEASAHVPLLIMGPGIQANLQVSNVVSLVDIYPTMLDIAGIPLPQNLSGYSLLPLSSETLKDEDKFKNLHPPWILSEFHGCNVNASTYMLRTNQWKYVAYSDGASELPQLFDLSSDPDELTNIATKFPEITFSLDQKLRSIINYPKVSASVHQYNKEQFIKWKQSVGQNYSNVIANLRWHQDWLKEPRKYESAIDQWLKTHTNPKNSEQK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MDQQQRATVAFPPPLEEYKQFTKDGENPIQPPEIPDTPFSVFNKPQNDDDVPSLESQGIPVLYDPSEPPLLELKKINHQILFTIQDLFQTLAGGNENPDKTLDQMKYLFMNAHYLLHKLRTVQAYEHMHHCLREKKRQLDLFQKRFDDQLAMVVQLKPP
The following text describes a protein:
Function:
Required for degradation of unstable forms of cytochrome c.
Subcellular Localization:
Mitochondrion envelope.
Sequence:
MILLKRTKIRGVSVSFVSLQRRTHSRLVNPIRQQHQQITKQRSSKILKNAHFYDFRSLPKVPTTQYLEARELTRDILYSGYRPVMYPVKENPLFRDKKRKSLQTLLTMNEKTNAEAKTIDEKKHKNILFGERGTGGIMSGGVNGTWKYNPTVPNELLPFNWWSTSSMGMEYFPEWKNVPPYMMRKLKPFDKALQMRLTHKSKKKMK
The following text describes a protein:
Function:
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Subcellular Localization:
Secreted.
Sequence:
MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINATLAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL
The following text describes a protein:
Function:
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Note=Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage.
Sequence:
MRCNIKRLFTLAIGVFAATLVIISFSKDNYEREWKQGPQSNEARAVGHQSPDLFPVGQNSLPHQPIPPSLGEKDLSDPFNFLFSSNKITLRKLYDLTKNVDFDQLRQNECKKNITLSKFWEKSEQRNVPEDDNWERFYSNIGSCSVYSDDQMIDNLLHDLNTSPIKHVHIMDGGTQVKFVFTFKNDKQAVFKPMRFGRDYESDPNHFYFSDFERHHAEIATFHLDRVLGFRRAIPTVGRVLNMTTELFEKAEKKLKKTFFFSPAKNFCFVSRCDYYCDTTHAICGLPDMKEGSVQVFLPDESAVPRKHNRSPYRRTYSKKNQVAEWQSSMNYCTDKVKTKRQYAHGRRLLDLVDIHILDYLIGNQDRHHFESFNVFNDLPSYAIHLDHGRAFGRSDFDDDDIILPLRQCCILRPSTFQTLMNFYSTPKSLTKALHESLSKDPAHPILAYKHYPAMERRLAKIMSHILECFESRGVAEVLVAEYNNPDVSDAEQNDEEQSEEHQDKKDDKKTV
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Sequence:
MIVNHKLPLESLLYCAAPMVGQSDLAFRLQTVQNGATLTWTQMYLAPELSSDQYMLESLLKSLEMGSNATKNMARYRASPLHDQSAPQVVQLAGNNVQQLVEAARRVAPYADAIDLNLGCPQRHAEQGHYGACLLPKQNWPLVAEIVSGMVQAVDVPITTKIRLPVPKEQTAQLAVMLAHAGSSLVTVHPRFASSARRRKGLADLDQVVKVREALQAQGLLRSAEQPHKDTAVVSNGNVQCWQDVVNNLELTGASGVMVGETLLQNPALFRPALRDCEHARLPTAKEMAIEYLDFRDTYDQFESPLKVAKQHLQSILCSIPHTMHNHPDVIAERHRSAASMTRTLNRIQSDSDLGWFRKEHLQK
The following text describes a protein:
Function:
Bilirubin reductase that catalyzes reduction of mesobilirubin and/or bilirubin to urobilinogen, a key step during heme degradation. Cooperates with BilS, which is probably involved in electron transfer for BilR. Urobilinogen then spontaneously degrades into urobilin, which gives urine its distinctive yellow color.
Miscellaneous:
MISCELLANEOUS: Bilirubin reductase is a key enzyme in the human gut microbiome. The enzyme is essential to human health, as excess serum bilirubin can cause jaundice and even neurological damage. BilR is nearly universally present in the gut microbiome of healthy adults, while the prevalence of the gene is much lower in patients with inflammatory bowel disease (IBD) and in infants, especially during the first few months of life when infants are most susceptible to developing jaundice.
Sequence:
MYEKINEPLSIRGLKLKNRIVFAPTTMGLSEEEYLERLGIIAAGGAAMLVIGDVPVLRHSLFAKSLYSTKGFEFYRRVTEVIHKNGAKACAQLHVSDSDIKGMLRFVPGMLMKRITPDRLRELMNERTGPYITGIPESKIGKITASFGDAAVLAGKAGFDMIQVHGDRMCGSFSSSVFNHRTDSYGASAANRAKFACECIAAVRQALPDMPVEYKLAVRQENPHYGNAGILVEELPVFLPLLEKAGVDSYHVALADHSSLSDTIPPKSHPYFSGEGCFLKYCDEVKKYSSLPVCAVGGLTNPDFVEEQLTRSRIDYAAMSRQLIADPEWPNKTAGKNQDKIRFCVRCNRECLGGMMEHRGVHCIYDKKKEDVQ
The following text describes a protein:
Function:
This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy; Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
Miscellaneous:
MISCELLANEOUS: Plasmid PAO3 is a small colicin E1 derivative.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
METAVAYYKDGVPYDDKGQVIITLLNGTPDGSGSGGGGGKGGSKSESSAAIHATAKWSTAQLKKTQAEQAARAKAAAEAQAKAKANRDALTQRLKDIVNEALRHNASRTPSATELAHANNAAMQAEDERLRLAKAEEKARKEAEAAEKAFQEAEQRRKEIEREKAETERQLKLAEAEEKRLAALSEEAKAVEIAQKKLSAAQSEVVKMDGEIKTLNSRLSSSIHARDAEMKTLAGKRNELAQASAKYKELDELVKKLSPRANDPLQNRPFFEATRRRVGAGKIREEKQKQVTASETRINRINADITQIQKAISQVSNNRNAGIARVHEAEENLKKAQNNLLNSQIKDAVDATVSFYQTLTEKYGEKYSKMAQELADKSKGKKIGNVNEALAAFEKYKDVLNKKFSKADRDAIFNALASVKYDDWAKHLDQFAKYLKITGHVSFGYDVVSDILKIKDTGDWKPLFLTLEKKAADAGVSYVVALLFSLLAGTTLGIWGIAIVTGILCSYIDKNKLNTINEVLGI
The following text describes a protein:
Function:
Possesses RNA-binding and ribonuclease activities in vitro.
Subcellular Localization:
Nucleus.
Sequence:
MRTPMSDTQHVQSSLVSIRSSDKIEDAFRKMKVNETGVEELNPYPDRPGERDCQFYLRTGLCGYGSSCRYNHPTHLPQDVAYYKEELPERIGQPDCEYFLKTGACKYGPTCKYHHPKDRNGAQPVMFNVIGLPMRLGEKPCPYYLRTGTCRFGVACKFHHPQPDNGHSTAYGMSSFPAADLRYASGLTMMSTYGTLPRPQVPQSYVPILVSPSQGFLPPQGWAPYMAASNSMYNVKNQPYYSGSSASMAMAVALNRGLSESSDQPECRFFMNTGTCKYGDDCKYSHPGVRISQPPPSLINPFVLPARPGQPACGNFRSYGFCKFGPNCKFDHPMLPYPGLTMATSLPTPFASPVTTHQRISPTPNRSDSKSLSNGKPDVKKESSETEKPDNGEVQDLSEDASSP
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MDTEALANYLLRQLSLDAEENKLEDLLQRQNEDQESSQEYNKKLLLACGFQAILRKILLDARTRATAEGLREVYPYHIEAATQAFLDSQ
The following text describes a protein:
Function:
ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA). UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U.maydis. Export of UA is presumably catalyzed by the ABC transporter atr1 (Probable). Atr1 appears to be quite unspecific, as many of the UA derivatives produced by cluster mutant strains are readily exported (Probable).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRFRSDSRADHQHPKKQGSMDPDTIQALKYQDRSSSSSSNNKPKEKVGSASTSPSPTLFASNDSVKVEIGVGSSDKEKPDVKVSFFTIFRYASKRQLLINLFGTGMAIAAGAAQPLMNIFIGKIATVFLHFTSAIRSGDLDAIRAAHSDVYSTINSDALILLYLGIGMFFASMLYMAVFSYTSERIASNIKYAYLSSLFSKPIDFFEQCGQGTVAAKIGSDVHLIQIGIGEKLPMAIMYFSTFVTAAAVAFAFSWRLSLVLLPIAPLILLAGGVMGALTKGCKLVELDCIAKAASRAEEAFNAIKILKAFSKERTIGQEYDTLTTDTKAAGAKAGRIQGVGVGALLFIIYAGYALAFFYGAQLIARGELLPGRIVSVVFANFAGAFAIANLFSMIENFTMATAAASSVIGTIQQDLASSELSESRRNEEKSQTSRQLATGYNAELKLDHVHFAYPSKPERPVLKDLSLTIPSCVTTAIVGLSGSGKSTIFALLQRFYAPTRGSIRLDDVDISALDVDWLRGQIGVVEQQPTLFAMSIQANIELGLPNRHTRSAEELESLVVQAAKKANAHNFITALTHGYQTEVGSQGFLLSGGQKQRIAIARALIRDPKILLLDEATSALDSKSEAVVQAALDEAAKDRTTIIISHRLSTVRNADNIVVLGPDGIIEQGSHHELSIKPNGTFASMLRHQDDKTKPVMVTSEPEIVDSSHSLCLTEIPTMEIAHSLEVSRTISALADSVKPKDPSKNFEPPGESYASPAADGVKQDAPKTDSVGLRTLLHILIKDPETGRLAQLYMLGSLCAAIIGAVYPVYAILFGTAIEDYAPCNSSDGRPCPNPARGTMLHNNRISSGSFFIVAVGCAFISFYHVRSLYIAGSRVTHRLRVLVFQSLLCLDASFFDDPVNTSNDLASSLSVLSQGIYGGVGPTLGSIVQSLATVIVGYAVAIGYGWRLALVVIASTPLTITAGLLRLRVLARKESKTKQAHQHTTQQACESIGAIRTVSAFNLQPQTLQVYQKNLENASRSLRPTMCYSSVLFGLSQCVQLLVTALAFWYGGRELAQGHTSSKGFFTILISVVYGSVQAGNIFNYSADFSSAHSAACKSLSILKQAKEVVAEAQANDRDVQWNTEDSLPSGQIALKEVTFRYPQRPTCTVLDRLSLTIEPGTFCAIVGGSGSGKSTVLQLIERFYTPESGRVLLDGYSITEGDPARFRKYMSYVPQEPTLFQGTIGWNIALGATDENPEDVPLAKIQQAAELAQLGDLLASLPEGLNTQLSARGVQMSGGQKQRIAIARAMIRDPRVLLLDEATSALDPASERAVQGALDNVSQGRTTIAVAHRLSTIAKADKVIVMQAGKVVEEGSPRELFQRDGLFALMARLQGVSF
The following text describes a protein:
Function:
Transcription factor involved in regulation of gene cluster that mediates the biosynthesis of aspyridones.
Subcellular Localization:
Nucleus.
Sequence:
MHVDSRGNAPVRRRRPAVACTECRRRKIRCDQATPCRHCEKAALRCIYNHLRPNTSQSKISPPTSASGFISGSQLSVNDSPQLPLSNDTKFHGFGSGSLKSDLSLEYVPSALPTSSSIFVEPNSLSSLSEPLAWEIAPPETGVGILAESDSPLNMQGQTGELRDQHTAPWMEILHCDPDEFWFDSEELRRMWRKTRDLELLLATSKMPSEWLYWSPGPTAPEASSLIPPRATCDVLLELQYWSSPDSMSDVFLCKLLLAMAIGTLFAPASPSAGQLTDMRPRALAWMHYGQQWLFRKIVLDAQLNLDILQTSPTSIGDRHFWLSEDCLVRMAMKLGLHRDPHIHNPAMLGTEVEVRRRLWVTLLELSLQASLDAKLPVPLPSDGGFDTELPSNLSDTDLGSIATLCNPNPRTFFTHSTMQILLAETQRIRIRILNLLYSPATSIPYQEALKLASELRRACNTNLRLLQSFTPQTPGAMMPTEFQTKILDLWTRRFLLALLTPYADEARSDYSLYYTRKARIDASSLLLSYPLSHSTATGPSPIGSYYLQLQISGQGIFRNVLKQATAAICQDLIQELVEDAFPVTDREPHAKLCQIIRDSISIYRTRMELSQPCMQEYVAFVCASAQIGALRSRCDNKHDFFPTAKKALGQCHHILESNHRSNSPEKYRAETMHVLDIDQGMNFWSDLLSTAGASPLSPPSSSSFFLEHGLSHTVPWEAPHSREVVDNER
The following text describes a protein:
Function:
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MHIEINHIHNLKIILSLIFVVNVICKLSENFFSFILGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKTSAKEEDAFHFVSYVPVSGRLYELDGLREGPIDLGACNQEDWINAVRPVIEKRIQNLKKFCKKSAFNSYHMCCPPTPTFVFILYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDTDQSTNMLSTIQSEVAKHQMLIEEEIQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKVSQKVNAKKIVSTCNFF
The following text describes a protein:
Function:
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Sequence:
MQEPLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAVGVDRECRAAEIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRILGPQFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILAQQPVPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRTATMGRKVTIG
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
MTHYEGDLRPTTARFVIIASRWNARITDALVTGARQSLAGNGIGEDAIDVVRVPGAWEIPMAANRVAQGGQHAAIIALGCVIRGDTRHYEHVADLCAEGLMSVQLQTGVPVLNGVLAVERVEDAEARAGGSHGNKGEECALAALELVNLMELLP
The following text describes a protein:
Function:
Transports natural purines (adenine and guanine) as well as purine analogs. Confers sensitivity to 8-azaadenine and 8-azaguanine (8-azg).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGREKTLCKSWSDMKKHLNDTVSKSFIGRFFKLEARKTTFTTELRAATATFLTMAYIITVNANILADSGATCSINDCSTVASSSPPGPECVLGSNPGYEQCISRVKKDLVVATSLSAMVGSLAMGLLANLPFGLAPGMGANAYIAYNVVGFRGSGSISYHTAMAIVLLEGCAFLAVSALGLRGKLARLIPQTVRLACAVGIGMFIAFVGLQMNQGIGLVGPDKSTLVTLTACAETDPVTGACLGGKMKSPTFWLAVVGFLITSFGLMKNVKGSMIYGIVFVTAISWIRGTQVTIFPHTPLGDSNYNYFTKIVDFHKIQSTLGAISFTEFRKSEVWVAFATLFYVDLLGTTGVLYTMAEIGGFVEDGKFEGEYAAYLVDAGSSVVGSALGVTTTATFVESSAGLKEGGKTGLTAVIVGLYFLASMFFTPLVTNVPRWAVGPSLVMVGVMMMGVVKDIRWGETKEAVTAFVTILLMPLTYSIANGIIAGIGIYLALSMYDVVLGVAKWLNGVRKRVMREHNQVSSVATVEIV
The following text describes a protein:
Function:
Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins. Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO. Has no catalytic activity towards oxidized glutathione (GSSG).
Sequence:
MLKKFQYDLFVVGGGAGGLASSKASALLGKKVGIADYATPSPHATTWGTGGTCVNVGCVPTKLMPFSARMGEIRKDQIAAGYRGIESEGKHNWKQLIETVQKHIKELNVRQESSLKDHGIDYYNKFAKFIDRHTIELTDMKGEKETISAKNIIVCVGSRPILYQDPKLVITSEDVFQQTSPPGKTLVIGASYVGLECAGFIHGFGFDTTVLVRTRVMRNFDQEMASKVEGYMTENGIKFVKRALLQSISAVDNGKRRLVKWVRDGVVEEDIYDTVLYGIGRQASTKQLNLESLGVKIDARNYKIMADEYDRTTVDNIYAIGDCCLNRLEYTPIAVMAGRKLAKRLYGNSNEIMDYADVATTIYTPIEYGCIGLSEERAKQKYGDDGIKIYRSHFKPLQWGFRQRDDAKYCGGKLIVNKESDRIIGFHYVGPEAAEVTQGFAVAMKMKCTKKDFDNTVPIHPSLAEEMILMK