lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity). LUBAC conjugates linear polyubiquitin to ikbkg and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) to conjugate linear polyubiquitin to ikbkg and possibly other components contributing to the stability of the complex (By similarity). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity). Binds polyubiquitin of different linkage types (By similarity).
Domain:
The RanBP2-type zinc finger, also called Npl4 zinc finger (NZF), mediates binding to 'Met-1'-linked polyubiquitins; The UBL domain mediates association with RNF31 via interaction with its UBA domain.
Sequence:
MSLSSGGWTRASPPAQSSSSHLGHEASQSACSTVLMSVKVSVCHSGIRPLCLPGAGDESLRLQLSMDPGKAGEFRLALRDISATAAGRSVFIAEFDLKTVQYEVKTPLCHELSLATPPHDRISFKFRCEQEAQEWATVVMSSLREAHRVAISSSTEEGRLPPPPLATQSKAPMPRTEEICAELVSAIEAGDVRSASVCASSLAKQKAALSIQPSKRNYTDSEVCLAVVVEDASSSCCVSVKVFPHSTIGALKQQVFSDYGFHPRVQRWVIGQSLCSDHRSLASYGVQRDGDTAFLYLISARQARLSRGIYQQDQESALLMVPTTHQAHQEAVSNGPAALNTASRPYSTLPTRLHNSHNTLSNNAGGSERLGLSDIRDLINLELPQLNEALGPNRTSIQPGWACPTCTYINKPTRPGCEMCSADRPEGYTVPGNYRPDALELRRIQQEKEAIRQYQQARETERRENFARLVQMDGQDLVPNPERVECRICYVELESGEGVLLRECLHCFCKECLRSVILMSEDPQVACPYRDESYACDCVLQEREIRALVSVDDYQHWLQRGLSVAESRCEGSYHCATADCPGWCVYEDTVNTFHCPVCKKQNCLLCKAIHEGMNCKQYQDDLTARAINDSAARRTRDLLKTLVNSGEAMHCPQCGIIVQKKEGCDWLRCTVCHTEICWVTRGPRWGPKGPGDISGGCRCNVNKQRCHPKCQNCH
The following text describes a protein:
Function:
Acts as a magnesium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSMNTDEKERVQEELYDQTLLDQYLENDDIDQFRDEFLALHTYEQSEYFEDTTDENRQKIFQYLSPEEVANFFDQLDIDDDEYELLFDKMNATYASHILEEMSYDNAVDILNELTKPKVASLLTLMNKDDANEIKALLHYDEDTAGGIMTTEYLSLKAHTPVKEALLLVKAQAPDAETIYVIFVVDDDGKLVGVLSLRDLIVAENDAYIEDIMNERVISVNVADDQEDVAQVMRDYDFMAVPVIDYQEHLLGIITIDDILDVMDEEASEDYSRLAGVSDIDSTNDSIIKTALKRLPWLIILTFLGMITATILGRFEKTLENVALLAAFIPIISGMSGNSGTQSLAVSVRNITTGEINEQSKFRIALREAGSGVLSGVVCSTILFTIIVAIYHQPLLALIVAGSLTCAMTVGTFVGSMIPLLMNKLNIDPAVASGPFITTINDIISMLIYFGLATSFMAYLI
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Sequence:
MKIEVNENLIKHLENLSLIQLSGEEEKILEKDLANIIKFFEKINELDLSNVEPLFHPLPQGRLRKDVPRDPLDRENALKNVKRKEDGYIVGPRTYGE
The following text describes a protein:
Function:
May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKVQLLKIPSHLIVAGSSWLSKIIIAGVQLASISYLISMLGEEKYAIFSLLTGLLVWCSAVDFGIGTGLQNYISECRAKNKSYDAYIKSALHLSFIAIIFFIALFYIFSGVISAKYLSSFHEVLQDKTRMLFFTSCLVFSSIGIGAIAYKILFAELVGWKANLLNALSYMIGMLGLLYIYYRGISVDIKLSLIVLYLPVGMISLCYIVYRYIKLYHVKTTKSHYIAILRRSSGFFLFTLLSIVVLQTDYMVISQRLTPADIVQYTVTMKIFGLVFFIYTAILQALWPICAELRVKQQWKKLNKMIGVNILLGSLYVVGCTIFIYLFKEQIFSVIAKDINYQVSILSFMLIGIYFCIRVWCDTYAMLLQSMNYLKILWILVPLQAIIGGIAQWYFSSTLGISGVLLGLIISFALTVFWGLPLTYLIKANKG
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MVLGLDKRALWGALPLLGFAIGHFLDKKETERMTMFRDKSALYGRPAGSEGKAPSW
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MKFEESMELPVIVVDSGVLLPGASLKIPIRSKLNTRTIEQHLTRGGSNYVVIAYKLSTDKIYNVATIAYIEKLFGWTFNSTTNYSLDVIGLHRANIDKLSFPKCRVSKLEDSSERAEFNHSTIENVISGAKILAQNSESLKFSQEIHNSIDDHDYGKLADLCVSQIKNLEFSQFLDFLGTKNVEKRLEMCEKWMQMQRETKALQLKMAVPGNSEIPKKINKQRIPNSKNQVEQLEEKLSAIEFSEEVSDRVFSELHRLKNMNPQQSEYTVLMNWLELVSNLPWNTSTVDDIEINKARKILEDSHESMDDVKQRVLEHLAVCKINNSVKGMILCFTGPPGIGKTSIAKAIAESMGRKFQRVSLGGIRDESDIRGHRRTYVAAMPGRIIEALKHCKSNNPVFLLDEVDKLYSGNQGSPSAALLELLDPEQNSTFHDHYLNIPFDVSKIMFIATANDVERLEPALKDRLEIIEMSGYSMKEKVKICENHLVNRQLSKHCISPDYVNLDRHAIMAMIEEFTMEAGVRQLERNVGAVCRHVALRLAEALNSDPSADVLPDMDLPIQIGEPDIHKILKAKHMKRVKIVEKMRPLPPGVCFGLSVTTNGGRVMPIEASKCKGTGKIVTTGHLGKVLEESILVAKGWLGANAEKLGLKTLEENDIHVHLPAGAVNKDGPSAGTGLACALVSLAMGVPLRSDAAVTGEISLTGHVLAIGGVKEKVLAAQREGLRRVVLPKSNEEEYLKIDEDIRNEMDVVLADTVEDVIEAMMEKEPVLAKL
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
VKKKKKSLYAPLTRDELFTIKETESLYRSGLFRMQIDELLKEVKLKKKRNKKLDLFLHALRNCLINIPDDNQQELEFDSLSCKPDGIQIPLHLKDVQTIKGKFIFKTPTVIAVVGSYMIGTITKPIVNVDVTVEIPQECLNSRDHINARYYYRRALYLAHLAYHLNQSDICQEVQYSTMNGDPLKPILVIKAAPERFNRYFTIRLYPCINQSAFKLSQLKPTKDNIRYEFYPTIESKLNEETQRLGPPTPHYNHGILVDMSFGRHLREIYQATRQSQSLIDAITLIKIWLYQREFNKGINGLNGFLASMFLIYLLKKKKLNLQMSSYQILRIFLIQLASSDWSTNGITLAEQDNSNIPSTAEFSTVFEVVFIDSSGYLNLAANLTKISYDELRHAASSSLRHLDSSSSDVFSDLFVKKVPYFTKYDHYITLKQLPQIEKANIGQEVLEYLISRCNHLRPVMLRWLMVILQKGLNKRVKLISVMPEDISKWPITKMPPAESETVTIGLSLDTEQYSSIVEMGPSAEDSQAAELFRKFWGEKSELRRFKDGAIKEAAIWQCKNIAERRFICERIVKYLLQLHGKISPENVNYIAGQLDHTLAITYEDEKSKLPFCNNNATEDAISIIKSFNELCKQLRLLKGLSLSINTIQGISPVFRHTELFPSKPAKRFKSRTRLSDDVQFRNVAKNVLLPTANKTCPEWIPANEAVCSMELSGDWPQNAEAVQRVKSALHLEIARLLSQHYSLLAVGQTNYIDVFKDGYVFRVRVAYHREPGLIRLVENEGNELLAAELEKTTILLPQFATMINGVNEQYHSYSTTVRLAKRWISSHQLCGYVTEECIEVIVASLYLNPETYDKPGSEINGLLRFLKLISTFDWLNFPLLVNLNEEFSGSDMVEIGTDFRENRSKFPAMFVAVPKKKLNQLLTTSKLTNSILHRLTLLASESYNLLIKQLSTCASEKVDFMKIFRTPMEDYDVIINLNLENVCRFHEGIDSVVTECHSDLNKKYMPVVNFDPVEYYLKELEDAFGDIALFFYNKYGGDFIAVVWKPDAFKLQSFKGSSKKLLMCPDKESILQDFRLLGDNLVSSIESK
The following text describes a protein:
Function:
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein.
Sequence:
MFSFNLLTIFSSIVNLLALAWIIKRYFLGAIIRIMNERREKIELAMKEAEKKLQEAEELRKQRESQLAQARDEAAKIVNEAIVTAEKMKRDITAKAEEEAEKIIVKAHEISMAERKRVLETAKKEVLSLSRLIIKEFFRRFLPVEAEELLINQFVDSLNLLIVNVKGDNIEEIRFVSPDNVSGQIKKKIEDKLRSLLPGSWKLNFELDPSIGLGFKLFIGEFLIDNSLDYHLSQIYDSIREVENI
The following text describes a protein:
Function:
May be involved in the early secretory pathway.
Sequence:
MALTLRKKQLDSIVRMLHLNQQLQGSPDGVGGGVGSAEEEEAYKILVMDSPCVALLAPVLRVGELRRHGVTLHLNIDKARQQVPDAPAVYLLRPTAANVDRVAADAAAGLYASFHLNFSTCVPRALLERLASATAASRSAHRVARVADQYLDFVCLEEGLFSLAQPRAYVALNDPAAAEADITALVDAIALGLFCVVATLGAVPVIRCAGGGPAEMVAAALDARLRDHLIAKPNLFTEAASTAVASFQRPLLCLFDRNFELSVGIQHDWSYRPLVHDVLGLKSNKLKLPEKYDLDDTDPFWVANSWLQFPKVAEEIEAQLAKYKQDVDEVNQRTGGGRDGVEFDGTDLIGNTRHLMNAVNSLPELTERKKMIDKHTNIATALLGHIKGRSLDGYFECENSMLVDGTLDRTKLMNLLRGNGTKEDKLRLAVTYLLSFETPVPSDLEQVEAALRESEVDMSAFQYVKRIKSLNSQFAGASNTASKVNIVDWAEKLYGHSISAMTGVRNLLSDGKQLAATRAVEALMEGKPNPEVDNYLLFDPRAPKSGTAGQFRGPFREAIVFMIGGGNYIEYRSLTELTQRSQTTKQVIYGATEILNGVEFIQQLSELGQKAGLGGVSSSLPPQ
The following text describes a protein:
Function:
Catalyzes the epimerization of various hydrophobic and polar dipeptides. Has epimerase activity with L-Ala-L-Ala, L-Ala-L-Ser, L-Ala-L-Thr and L-Ala-L-Trp (in vitro).
Miscellaneous:
MISCELLANEOUS: Part of a large, functionally divergent protein family. Protein modeling and substrate docking were used to predict the substrate specificity, prior to biochemical analysis.
Sequence:
MLSIGSLCLSLGTTPKPLKPSKTPKPIRKLYATKAMAGSNPKQVSTFEFRDLMETFAVDVKRAENRPLNVPLIAPFTIASSRLDKVENVAIRIELSDGCVGWGEAPILPFVTAEDQSTAMIKAREACELLKNSSSMKLGLVLERVSEILPGHEFASVRAGVEMALIDAVAKSINVPLWILFGGASDSITTDITIPIVSSAEAAELASKYRKQGFQTLKLKVGKNLKEDIEVLQAIRAVHPDCLFILDANEGYKPEEAIEVLEELHKMGVTPILFEQPVHRDDWEGLGHVTHIAKGKYGVSVAADESCRSLVDAKRIIKGNLADVINIKLAKVGVVGGLEIIEEARTSGLDLMIGGMVETRLAMGFAGHLAAGFGCFKFIDLDTPLLLSEDPVLEGYEVSGAVYKFTDAQGHAGFLDWDNVL
The following text describes a protein:
Function:
Required for the accumulation of coenzyme A in the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGSSQESTFSSASTAAQVNALDLLPVYAKELIAGGAAGAFAKTAVAPLERVKILLQTRTQGFQSLGILQSLRKLWKYEGIRGFYKGNGASVLRIVPYAALHYMTYEQYRCWILNNAPSVGTGPVVDLLAGSAAGGTAVLCTYPLDLARTKLAYQVSNVVQPANSLGNFGRQPVYNGVKDVFKTVYKEGGVRSLYRGIGPTLIGILPYAGLKFYIYEDLKSRVPEDYKRSVILKLSCGALAGLFGQTLTYPLDVVRRQMQVQNKQPQNANDAFRIRGTFQGLFLIIRCQGWRQLFAGLSLNYVKVVPSVAIGFTTYDMMKNLLGVPPREKAHPLTGNSNK
The following text describes a protein:
Function:
Acts as a negative regulator of vacuole-dependent ubiquitin degradation.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTSYELSRELGGHKQDVRGVCSISNELIGSASRDGTYSVWEQINGEWTPHFYENHEGFVNCVCYVPAIDKNSRGYIFSGGQDKCGILQEVGTNSPSYYLFGHESNICSASALNSETIITGSWDSTARVWALGQCKYVLKGHQSSVWAVLALGEDIFITGSADKLIKIWNGEKLVKSILAHNDCVRSLCQIPGGFASCSNDGVIKLWTSDGEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIWKGKECLQCITLPTTSVWSVSSLPNGDLVCGSSDGFVRIFTVDKVRVAPTEVLKNFEERVSQFAISSQEVGDIKKGSLPGLEILSKPGKADGDVVMVRVNNDVEAYQWSQKENEWKKIGQVVDAVGNNRKQLFEGKEYDYVFDVDVADGQAPLKLPYNATENPYQAANRFLELNQLPLSYTDEVVKFIEKNTQGHSLESKKEPNLESQSSNKIKTTIFPVSQLLFSNANVPAMCQRLRSLNNTKSNPLPAKSIDSLERALSSKKITDTEKNELLETCLSILDSWSLAERFPALDALRLLAINSSSDLAPIFLEVFSRVVKSVPSSGNFESINVMLALRGLSNVVPNITDAEGVSKLMDCLTSTVPQASSAKDFKIAFATLAMNLSILLIQLNLENTGIELLSILFSFLDDPSPDNEAFYRALMALGTLCTVPDIALAASQIYHAQSIVHGIAERFSQEMRFVDAEKQILSLF
The following text describes a protein:
Function:
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes. Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species.
Sequence:
YKIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITGKSLCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNLPGMHSSDKPCRPKSE
The following text describes a protein:
Function:
Transcriptional repressor that may regulate multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing OFP11 have no visible phenotype.
Subcellular Localization:
Nucleus.
Sequence:
MSNFLRKKLHLCFSSSGGLSPSIPSSPIIVSNHNAQSHPHHTPSIFINNFNSLYDQLSVSSPLHRRHSSENPAGVFSTNRREEEEEDETTTSVSKLLSGGTAIMKHIESPDPYRDFGRSMREMVEARDLTRDVVADREYLHELLFCYLYLNPKHTHRFIVSAFADTLLWLLSPSPSPEHFLS
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MGSDLPSDIQQDINNFENVLDKLESQLESFFKVPLKEHQQSLSPIESAKLNITIAYALNSLFFMYLQTQGVSPHDHQVKTELDRIKPYVQKLKTLSNNNNNNNTNDETVIDNQSTKKRKK
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters.
Subcellular Localization:
Nucleus.
Sequence:
MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAVHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALLGVCNIVQQEWGAAIPCQVVLVTDGCLGIGRGSLRHSLATHNQRSESNRFPLPFPFPSKLYVMCMANLEELQSTDSLDCLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTSDVQVFPRPEPFIIDEEIDPIPKAINTDLEIVGFVDIADISSPPVLSRHLVLPIALNREGDEVGPGITDDTEDENSANQIAGKIPNFCVLLHGSLKVEGMVAVVQLGPEWYGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGDDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKVASTGASEYTAYDHNIAPLQTDFPTTSTERM
The following text describes a protein:
Function:
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
Sequence:
MPMFTSFDHQMMSRAIELAWRGRFTTSPNPNVGCVITRGEQIVGEGFHFRAGEPHAEVHAMRQAGELTRGATAYVTLEPCSHYGRTPPCAEGLIKAGVAKVICAMQDPNPQVAGKGVQMLRDAGIEVEVGLLEADARVLNRGFLKRMETGMPFVQLKMAASLDGQTALANGKSQWITSPAARKDVQRFRAQASAILSTSQTVLADNASLAVRWYDLPSSVQAQYAEADLRQPLRVILDRQHQLHPELALYQTPSPVLRVASENAELCISAENGKLDLRELLALLAQQHNVNQLWVEAGSQLAQSLIEQKLVDEIILYLAPKLMGSDGRGLFGALGLTEMAEAIELKIEDCRMVGADLRIIATPKTKD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSRGVKSSQSSAARAMVSSMGTPAGLSSFLGGFTTGLENRANAELESDYVVGLKLLNKTSEITKQKAFDRLLELMKSTSDQVLLQFASATVEAVIQHARHPKPSIRTSSYQLLQALMSKNKELKKTIVPELKVLSGVWVMGMNDMETAVCQAAAAAFDVAFPAEKKTLMLQQLMDAIMVSLRTAVEEVMASKKPLQDDALDPNANKIYAALKSMGYMVKQVSAAQTAVLKFVLDPQLYGALLPPREAPKSYLLVKTPLARSAVLALLRDVVSFCPASPKVHQLVSQALFGSILDPNVAMALRTWELLLFWCRSNVSDVVSHMKGGFLDDVVNCFMGCQHSELGEVIFPCLFPLLTSLSKDARCEGILDEFCAALVERLSVMSETPNVSAHDLGVVLTALMECWELHCVRKKTSRVSEDSVELLTVISFNVVKLMQTEAKATRYQAAIIAAMAKSLLKTANRCEDVCRQCLTVIGAQPGAAFRVLPDSPEPAVQRSFALFQARLLGRLCASTSTPPPPAPAATTTSPTTRTEGASTAHGKALVVDVANTWLLQQVAVRPDEQKWARLAAFFDETRDTQFYPSDAVADAVLDILCAYVRHTHGEDTSAQAHTRESRAALATLIKAGLEWKHRPASRDLMEATSSTQEHTLKEAALRHLMQDPARLCEVLTCAVAQCDVVGVSQCVAVYVERELTLSEEQRRGVLEALCTSVKETLAMVTESAADSDAGSTTTSDSASRYSSSETSSISSASSSTSSSSTSDSGLGSDMADVSASAAGGGDTANLAPEARERMKKWGQLLRSGGAFAGLLHLDAAYVVGHLLTPLSYISAAVATRVFVEQYISVKAMRVALQRQQHHSEDNDDLVAYAMERKVHWSSIADCNAVTAEVGELLDSYSVRAEDRDAVAMALLHSVFSDDDDLPLSFFAVYRLSQLVPYASKACLESFATSESGWQQAAVEVQVAALASNESALSLYDGYLSLDLLRPTFTTTVRTAQLVRLIDSVDGAAAAVAMANADPKTVARVFGQLLRVAAAKEVLADGVRRTLFGSVFPAMLACLDVAEVAVEVAALVTSTEGPMAAAGVPYLLPTLAAVLRDVAQAEDTVFLRRAVRLVSAVSSTAVTALFHAEGAKGISPVLAAAYTTFFSVLDEVADMLRFNIAAQLPAEQERLLLEASCQLPTWDLTTAKLTLVVLRHLASLPAVADSTVKSLIAYASKQTPLSGLELLAELSCTRIPTPDVYSELIRVIIDALCRCHRLRHLPSNGRLQKESGGSLMGSAPAALTTLRRVVMAAVLARRGVVLHSRMDSVLRSTVNLVVFDAVCEAVSQLRSTKEGEVAPLAKLIAFTSRFMGDLLTSDVMTLRGSKMSVEKIASVLCFAYAWLFATGIAKLEQLGVSTVASVIRSVCLLANLTLMRVTVPLAAPMQTIMQRFSLKPLREEYSTAQPAKVAQFRHQNSVLTKTQKQKMLLFPYLLSWCVYLTSAPPPPTEEAQGTGSNAACDKDWQRQVYSLLDLLFALMLTPMERVSTRLDSTFIGASLNPGAASDSSATGPLGFELVALTRVDAPDQMAQLARGAFAVFTQLLHDNTLSLTKSWLETVERKGRALFYSSVGQHITGILIQESFLSVLRHSPDGSSSFSVGDGCSVEVNVAQQLIDLSYEMEDAKVAVRITFPPAFPLHPPVVEYETGRECGVSLKKWRSWMLKMSVILFGGSANVWECIDLFHQNLDAHFRGIEPCPICFAVVSHVNHKLPDVRCSVCHNSAFHSNCLYTWWATGSNNVCPLCRSPWIAE
The following text describes a protein:
Function:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
Sequence:
RQAAGRGNPPGTGRAPGVSPAAPSWPGPLGGTASESQAVSDQPCRSSTWPSPCQSRWHRLSPKSSPGHVQKERSGRRKIPSLGPLLRSCTAGKLSEAPSAFHSGASRRWPVINEDKGDFNEEVTQDGVRVLIKKKAQRTLLGTEIVYAEDKLSSEFVFNNPNIKGTCGHGESFTI
The following text describes a protein:
Function:
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSAIKEVKSELRQFMKTLLGKISKEETQRQTEAVFEKIIESKWFQESKRLSVYVSTSGEIQTDSIIQKALEMGKEVFIPQFTKGSTAMDMVRVPDQTAFDNLPSTLWGIRQPEPKWKWQSYHETGPLDLILAPGVAFSPYGLRCGHGKGYYDRFFSTHHKHFPENSPKKIGLALREQIIGTIPISETDVELDEVIYEGETIIFDTI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDSGSRNGSHTNHDRDRHSNGTNGEVKASEKGRDKNQALSEPQQNMTPISPAVPNGMNGNLTDGPARQQNAGEDPIPKDILDRIHDLPPEVEHITFNFLSLTELLNRLAQSSHNELRQEITKLASMPTPQSAINGSSSHITKEDDTSNDNVNKKVSLLDFAQTQHSRWVKQLVLLDWSRKADQVSKIIDLNVHLIHKRGLYNIILAHIGDVKKKLCDIDSPSPDLKTAVEVLSTGKANWMPDLGYIPPPPMTSKEILKSLEKLNTLLSIRLNLHERQAVELSRSTWIDGVKVEPLHRALCIQYWLDRYKKNGPRSWIIIGVHSGRRKDGYHDPRTTSRLFIRWFRDSKEVKDMDILFDTVNISAEQLLKTVIAMHVNHILRSTHSKLAAEPIFANREASLSLHTSKTEPKESVLGVQLTEKQHLSITIEPVTGIFIFSPASRIITSSQNKLNSLDRDPATDAHYNIENLRCLAISEELTILGTSVGWRRADNPGISREDLKRKIPKDTKQITWFRRPGWQEDWLVAVTLGMTGESWWLFQTSKQPTGVKVLTSIHIPIKAVSPTPSYVFMSTLHIFAGGLISQYTNLKALHDRRIHHTIRQTGLPSPVKLPSIWIHISELFSARAKPAAQKTWAKDFLKLSFQGLEPFSALSSLPPQSPTDDPQATSHKLEQKAVLVTVARMAVPIPALSVLNEKIDKDIAFKAQTGEIAFRLRSQVGKSIIPSLTERLFQVERLISCTAVLRKHEKFIKCDTISLQEITFSYGMPPPAETGSDMGADKAKARSYKAVVSLGLVEGKMKLTLETGNPHIRVLDALDKVLNIPKGGFDAVTTLLPQTLSCLRAFETIEDAWAPLYDKGEVFIFVRAFEWFNLRYILKSSTPDTPPRKVSFEIKMCHRKQKPWWLVRRTEKTERAGKEEVLPDDGIDACLKSVWDSPGDDDWKGMRTSAVGRNRGIETCLEKVDAVIRNLSPEDLSLQPSQQSQSRMQAQAIGSQGQQSSHLQQQRQSQLPTPANSQNHSQSHGSSQGHQRMPAPNMNMNLNINQNMLKRKPSSQGINPRTAKREVVEID
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGSTLETVVFYFLAAFIIAMSIMTVTTQRIVRSATYLLFVLFGTAGIYFLLGYTFLGSVQIMVYAGGIVVLYVFSILLTSGEGDRAEKLKRSRFLAGLFTMVAGLAIILFITLKHNFLQTTNLVPLEINIHTIGNALLSSDKYGYILPFEAISILLLACIIGGIMIARKR
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSQGPADPFGKTRKASAPVGTLALAMIPATLALAPRPTNSRSKPDAPSLSLSLSLSLKKNSANSDKILNLLPFVRFYYFFSLSLSLSLFTQTNSFSLSLSLSLSLSLSLSLSLFLKPIQFSLSLSLSLHHFSDHVLKSDLWATGQSEKFNSCILGVAQLSGEVTVGAGTILHPTSRILATHGPIIIGENNNIEEQCLIENKQEGTVLIIGNGNVIRVGSTVTGRGIGNDNLIGPKAMVGANATVGNQCVVGPKCTITDCELADQTIVTSGGQVVRRDPTYTKPYALEAERQVLATTLDKFHPMQK
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Sequence:
MLSLLQRFLLTISLLLGSFSTLAQTIAKDEYSVSPLLNGEQIPAITLQDMNGQNVDLVKLTAQKPTIFFFYRGGWCPFCNNQMGQLKAIEPKLIEMGFQLVGISPDTPAQLKASSAKNELKYLLLSDEKMLASQAFGLAFYTSKQVTESYTNRLQLENPLWTTPEGDKGLVLPVPAIYIADKKGLIHFQYINPNYKVRPAPKLILTAASLVGSPE
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MASHSDPMAANVEVATSVNAEAAAAAVNVKAVAVAEATAQPVVNANNYLLQQQLQLFWAAQLQEIMQIGDFEGHSLPIFRIKKIMKSDKEVRMISAESPILLDKACELFIQELTHRSWLKAQECQRRTLKKIDFFTVLKKTKLFISLWT
The following text describes a protein:
Function:
Involved in sister chromatid cohesion. Forms a complex with mis4, which is required for the association of the cohesin complex with chromosomes.
Subcellular Localization:
Nucleus. Note=Associates with chromatin.
Sequence:
MTGLNETDARILVTSRHLFLWPLAETYFKNAEKVLQDCGVCDSFGRLLSTGLQCLYSVLMDTKMEPRVELLTRKRICEVLLSHTVEYADVEAILNRALIIAEQHNLTEYKFSLQLLLSRVFCRTSPKAAKVLLTRCVREAEEYAKVAEIYHSNNQSNPHRWVYEFLLATLEFQNVSQVANSIHNYANHHKHQHLQLLAMILNQSLPMDEISTDSDQISILCLVTQIAQCLRKGEILLAREILPKIHSKLESETFVWPSSYIDFFIDDTSKISIKWMSINQLYLLIYLISGFCYISDSTSGRASRFLQEGLRITGDFKHQERCVLEYLESQKWINNITKDMKYYLIATYLSRSRLSKAERILQSTEDDQTGFLGILKGMYLQKRGDLKKAEVHYRETAKNFSFRTDTFIISTLNLINILEDSAAASRCLESIEPLCNKHEKKIFKLWLLVLKVIREGPQVHQSNVLPRVIQQSSEYANTQLQYISLTELSERFGKLEHAEKMAISALELAKKSKDELWCLISGRILEDFYRSVQKYDKMRQQALENSAYSKLIEDIYSFV
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLKIIIPSIMLIPLTWFSNNKKVWINVTSYSFVINMIALVTLWQVNDITTNFSTMFSTDSLSSPLTMLTIWLLPLMLLASQKHIKNQTDFNKKMYISLLITLQVLLIMTFSANELIMFYILFEATLIPTLIIITRWGNQAERLNAGLYFLFYTLIGSIPLLIALISIQNTLGTLNIMLLSLDSSPQTPTWSSHILWLACIMAFMIKMP
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MLRKRKRTSFFKPSPSDCAVRPATGSEPFVDTLMEERIASLEPLIKKAPRSPLYLSHVKDLHSAMMRCTGEVSNSGVIVRAHKLLQTAVRRLSLEFHQILSSHLPYPDHAELLSSQSSRSSTLSSFSDFEYELEGKLSTKKSAAEPVMQEEERVPNAAVFDVKTIADCMIACGYGKECMDIYKFMRRSVVDEELYHLGFERPIDSWQMQKMDWKVLEAKVKSWLKAVKPAVQTLFYVERMLCDRVFTTAPPSVGESVFSHVARDAAVALFGFAEGAAKAIKRSPERIFCLLDLYEAIANLWPGIKATFSYDATSAVRSHAINSLIKLGEAVRVTLSNFEAVIQKDSSKKSAVPSGGIDPLTVNVMNYLVLLADYGGVLKDILVKWPVDGSPKHPGFPDSYFPGCDPATSITVGVSDASAKFARFAQLVDVLLCKLDVKAKRYKDVALYYLFLANNLQYVVNKVAQSSLKHLLGEHWVANHETMVKLYASNYERKGWSKVFASSPGPSVEISLGQAKESLRRFDAALEEVQAKQAGWAVTDQKLRDDIALSLAEELVPAYRRLYDGCPRGDPVVKFTPDDLDNYLAGMLRATGGGSATVSEAASRSSRAEGDER