lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule. Plays a role in cilia formation. Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors. Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MANKAKQSEALKVVARCRPMSRKEEAAGSEQILEMDVKLGQVTLRSPRAAPGELPKTFTFDAVYDASSKQTDLYDETVRPLIDSVLQGFNGTVLAYGQTGTGKTYTMQGTWAEPEQRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLDLKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITIECSEQGSDGQDHIRVGKLNLVDLAGSERQGKAGPNPGGGGAPQALGGGGGGGGGGERPKEASKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTIMVATVGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRRSSRRKKAAAGDGGPEAPLNEAWVAEEEDDNNNNTHPPQPTVETALENNMENYLQEQKERLEEEKAAIQDDHSLVSEEKQKLLEEKEKMIEDLRREQEALELLANKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTFSSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLYLDCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENILFLELDVSPPAVFKVEFSRDQDQDPRLLHLERLMQLDSFLERPTSSRVRKSRSWCQSPRLLPSSSSHVALASGSLRPSTTMSHE
The following text describes a protein:
Function:
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance. Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2. Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion matrix. Mitochondrion.
Sequence:
MARKYVPHTTELCENSLKKFKSLVGTVDKLLIITGAGISTESGIPDYRSKDVGLYTKTALEPIYFQDFMKSKKCRQRYWSRSYLNWPRFAQALPNFNHYALSKWEAANKFHWLITQNVDGLHLKAGSKMITELHGNALQVKCTSCEYIETRQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLGSEQGFKIPECLNCGGLMKTDVTLFGENLNTDKIKVCGKKVNECNGVLTLGTSLEVLSGYQIVNHAHMQNKPIFIVNIGPTRADQMATMKLDYRISDVLKEM
The following text describes a protein:
Function:
Has multiple catalytic activities. Apart from catalyzing the oxidation of (+)-tartrate to oxaloglycolate, also converts meso-tartrate to D-glycerate and catalyzes the oxidative decarboxylation of D-malate to pyruvate.
Sequence:
MSKKQYRIAVIPGDGIGKEVMPEGLRVLEAAAKKHGVSLHFDHFDFSSWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPAKIPDHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLANRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQTVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPEGDFPSVFEPVHGSAPDIAGQGIANPIGAIWSGAMMFEHLGEKEAGRSIVEAIERTLAERTLRTRDLGGNADTTACGKAVADMVD
The following text describes a protein:
Function:
Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle. Acts as a potent cell cycle inhibitor, regulating a hydroxyurea-dependent checkpoint in leaves.
Sequence:
MGISKKSQVSRELDTDGKKFIFAKTSIRASLKPVKTKLIKPERESEDGICITPTARGAKTPECPAAPRKRPPVLKCQNNIRIEYFVPPSDFELVFIQRR
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MWQIDFSIREKQATVSRSSAESEYKSLASTIAEPTWIIGLISDLGVQVQLPVTELKTYLQEVGCNHAHQRVGFHNDGFATTPTMRKSHLIWVNARMHIKTYKYLVWYLPLLALVYAWYKAVATMNSIVYDVEQE
The following text describes a protein:
Function:
Inhibits zinc finger homeodomain (ZHD) transcription factors, by interacting with them to prevent both their nuclear localization and their DNA-binding properties.
Subcellular Localization:
Cytoplasm.
Sequence:
MMKRLVVLRRREPAVRFSCCGVRYGECRRNHAASTGGHAVDGCREFIAAEDGGGGNSTSAVGVAAAALKCAACGCHRSFHRRVQVYEVAWDDDCASGDTSSSSPSSSSSLSSE
The following text describes a protein:
Function:
Anchoring subunit of the minor fimbriae. Regulates fimbrial length. These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. Fimbriae of P.gingivalis are major virulence factors (Probable).
Miscellaneous:
MISCELLANEOUS: The name (minor fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MNKRKHMDIRRLIISLPAIMALWGGLASCDKMIYDNYDDCPRGVYVNFYSQTECAENPSYPAEVARLNVYAFDKDGILRSANVFEDVQLSAAKEWLIPLEKDGLYTIFAWGNIDDHYNIGEIKIGETTKQQVLMRLKQDGKWATNIDGTTLWYATSPVVELKNMEDGADQYIHTRANLREYTNRVTVSVDSLPHPENYEIKLASSNGSYRFDGTVAKADSTYYPGETKVVGDSTCRAFFTTLKLESGHENTLSVTHKPTGREIFRTDLVGAILSSQYAQNINLRCINDFDIRLVAHHCNCPDDTYVVVQIWINGWLIHSYEIEL
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MDKPFIPDFYREKDIFVTGATGFMGKVLLEKLLRSCNGLRRIFVLMRAKGGASSQARLDELLDAEVSEPFLSVFQKLLTLLRLSINDNNHKIIRSEHEHKRALWENVDIVFHSAAIVKFDEPLKSSIDMNVLGTRRLLQLCQGMAFVHVSTAYCNCDKEDVAEIIYPPPFDPQSVIDALRQAGQTFSRTLVGPITPKLLGSRPNMYTFTKALAESLVAEERGTLPVAIVRPSIVTAAWREPIPGWIDNINGPTGLLVASGKGLLRSMLADTNKAADFVPVDVVINTMIIVAWYTATQRKEGYRWRSCPSCLGPCEWLHARSLLAPACDVVIADHSQWEIFSQIRCYSLAVPRGATKSMHSENKSLHRLSNSLFFLLRMVKLFTKLYKVMVSLEYFTTHEWRFNCTNLLALLQEISPADRKMFCIDLRLLNWGHYFKDYVIGTRKFVLKEDPSTVSEGRNKLRRLYIYQQLLYVGLVAFVWRLIMYKSKSACRLWRAVVSVFLPLLSLVSSVLGLPCSEDILKQ
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGTSSNASFHQQQPPMPPPRQQSRGNGLQTSLSLVSSDACGGSADNHEPASNTEHIRESPSESASSHETWPDENNRGEGTMENSGEHGKKALDKEKVIEEENNEPAVIRRVSSSDKITLLDVVREKIEIIAERMNSQSEELLESLKTELRTILEGTGGPQNREDIMILQKLVHGRTDLTANSLVRAHRVQLEILVAINTGIQAFLHPNVSLSQLCLIEIFSFKRCRNIACQNALPADDCSCEICRSRNGYCNLCMCTICSKFDFDVNTCRWIGCDVCAHWTHTDCAIRFGLISTGPGLKNGTGGSEMLFRCQACNRTSELLGWVKDVFQHCAPGWDRDALMRELDFVARIFRGSEDPRGRKLYWKCQDLLDRMKNGIVESTSCKSLLLFFQELEMESAKKPGGSAASDGTDDVSAAATGSTGPTMAPGEACRRIAEVVGEAVRKMEAVGEEKSRALKRARSSVEVCERELADKEREASELRSERQRQRRQVEELEAIVRLKQAEADMFRVKAGEARREAERLRQVASASIRGPSSEGERGPREEESAEGYLRMRLTEAEAEKRYIMERMRLQENGSSSLRLLMNNSVSESGAQQQQQQHQQQQQMLMLCKIQDLLKNVYGGAASGSKVEGQQQGSVAETAPPSSSFGNNTMKGM
The following text describes a protein:
Function:
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups. Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes. Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells. In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way. In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A. Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines.
Subcellular Localization:
Secreted. Cell membrane. Cytoplasmic vesicle, phagosome. Recycling endosome. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network.
Sequence:
MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKRNLRSYNPQYQYFPNILCS
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKKAKNVEKISFEDAMKRLEEIIDLMNQPTTSLEASLALYEEADQLMRICESRIQEVEARIKQLSDQRSES
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MASENMTPQDYIGHHLNNLQLDLRTFSLVDPQNPPATFWTINIDSMFFSVVLGLLFLVLFRSVAKKATSGVPGKFQTAIELVIGFVNGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHVLGLPALRVVPSADVNVTLSMALGVFILILFYSIKMKGIGGFTKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
The following text describes a protein:
Function:
Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.
Sequence:
MIKVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKKEGIITSEIVGHSRAVKRDIEIAAELEVDRIAIFYGVSDIHLKAKHKATREEALRVIAETISYARSHGVKVRFTAEDGSRTDFDFLVTVSRTARDAGADRVSIADTVGILYPSKTKELFSALIREVPNLEYDIHAHNDLGLAVANALAAVEGGATIVHATVNGLGERVGIVPLQQIVAAIKYHFGIEVVKLDKLQYVSSLIEKYSGIPMPPNYPITGDYAFLHKAGVHVAGVLSDPRTYEFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISEAEMDQILAKIKSNTTIRFYRDVDLLELAEEVTGRVLKPRPPEQIEALISVKCDSNVYTTSVTRRLSVINGVKEVMEISGDYDILVKVQAKDSNELNQIIESIRATKGVRSTLTSLVLKKM
The following text describes a protein:
Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
Miscellaneous:
MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLGFTEGIFLVLTVTEFILGNLVNGFIVSVNGSHWFKSKKISLSDFIITSLALFRIFLLWIIFTDSLIIVFSYHTHDSGIRMQLIDVFWTFTNHFSIWLISCLSVFYCLKIATFSHPSFLWLKWRASRVVVGMLWGALVLSCVCTMSLMNEFKIYSALTGSRDTQNMTEYIRLKRHEYNLMHVLGNLWKIPSLIVSLIAYFLLLLSLGKHTQQMQKYSVGSRDQSAEAHRRAMRIILSFLLFFLFYFLSFVILSSSRFLPETKIARIIGVVITMSYLVGDSLILILGNNKLKQTFVAILPCECGHPKPGSKRFFAS
The following text describes a protein:
Function:
Acts as a sensor for nitrate/nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate/nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLKRCLSPLTLVNQVALIVLLSTAIGLAGMAVSGWLVQGVQGSAHAINKAGSLRMQSYRLLAAVPLSEKDKPLIKEMEQTAFSAELTRAAERDGQLAQLQGLQDYWRNELIPALMRAQNRETVSADVSQFVAGLDQLVSGFDRTTEMRIETVVLVHRVMAVFMALLLVFTIIWLRARLLQPWRQLLAMASAVSHRDFTQRANISGRNEMAMLGTALNNMSAELAESYAVLEQRVQEKTAGLEHKNQILSFLWQANRRLHSRAPLCERLSPVLNGLQNLTLLRDIELRVYDTDDEENHQEFTCQPDMTCDDKGCQLCPRGVLPVGDRGTTLKWRLADSHTQYGILLATLPQGRHLSHDQQQLVDTLVEQLTATLALDRHQERQQQLIVMEERATIARELHDSIAQSLSCMKMQVSCLQMQGDALPESSRELLSQIRNELNASWAQLRELLTTFRLQLTEPGLRPALEASCEEYSAKFGFPVKLDYQLPPRLVPSHQAIHLLQIAREALSNALKHSQASEVVVTVAQNDNQVKLTVQDNGCGVPENAIRSNHYGMIIMRDRAQSLRGDCRVRRRESGGTEVVVTFIPEKTFTDVQGDTHE
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MSKISKAAKAVKKLDTGNVIRAIVRSGQAAPGPPLGPILGQKGIPIGQFCKDFNEKTKELKEGIPLPVKIHVKPDRTYDLKIGQPTVSYFLKQAAGIAKGASKTGHEVAGIVSVRAVYEIAQVKAQDECFKQRNAPLQTVVKCIIGSARSLGIKVVNDLSADEYKDFLEQREEKLKADAAAAAAAAAEAASSKKK
The following text describes a protein:
Function:
Protein kinase C; part of cell wall integrity (CWI) signaling pathway composed of pkcA, the bck1-mkk2-mpka MAPK cascade and the downstream rlmA transcription regulator. The CWI signaling pathway regulates cell wall integrity and pyomelanin formation. CWI also controls oxidative stress response, gliotoxin production, iron adaptation and asexual development. Finally, CWI is constitutively required for A.fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection. Modulates the expression of fumiquinazoline cluster during conidiogenesis.
Sequence:
MDGDDLIASVYRKIEREKALITAASNMRQSTDNPLVQQRVDANIRDGRKNIAYLEEKMRELQLRQMKQEGASPTDKRLPPNPDGSAPVPPPKDYAPGYSGHEREYGDASGAYPHGGAGTMPSGAPFADPRPFAPVPKARPNYTKLDLIKYDTPYLGPKIQLMLSQLEFKLSVEKQYKAGIEKMVRLYQDEGDRKSRQDAEGRRIESNQKIQLLKQALKRYEDLHVDIESAEAPDDESLSTPNLRKPLTGLLTLRIHAVEDVDHAASSRFSRGPETFVVVKVEDAIKARTKATRTDKWQDEPFNIEIDKANEIELTVYDKSGDRPTPIGMLWVRISDIAEEMRRKKIESEFNASGWVSADKMEHGAAHGRQDAGGAPGSSNRPPSGGHSGGPGQGYAGGAPGGASAGPVLIDSWFALEPVGRIHLTLSFAKQLKDRRPFDIGLNRQGAVRQKKEEVHEKQGHKFVTQQFYNIMRCALCGDFLKYAAGMQCADCKYTCHRKCYPKVVTKCISKANYETDPDEEKINHRIPHRFEGFSNISANWCCHCGYLLPFGRKSAKRCTECGLTCHAQCTHLVPDFCGMSMEAANQILETLIRAKNHNKSASVSSGLSGRTLRPGGPPQAPQDNVALAYPQKPVEGAYGAPQRQPSAEAISAATNTYIPPQSPTAAQRQHIPPRTSSSQSPAAAAAAAAAAATGLRTPQQASDPNRPVQPPPSSHAHYDPAAYASYQQAIPPQAMQKMGAPYGMPQQQQQQAVAPMQQQVAVKEEIPPQQPKVRIGLDHFNFLAVLGKGNFGKVMLAETKSTKKLYAIKVLKKEFIIENDEVESTKSEKRVFLIANKERHPFLLNLHACFQTETRVYFVMEYISGGDLMLHIQRGQFGLKRAQFYAAEVLLALKYFHENGVIYRDLKLDNILLTLDGHIKIADYGLCKENMWYGSTTSTFCGTPEFMAPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPELRLGSGPTDAQEVMSHAFFRNINWDDIYHKRVPPPFLPTISSPTDTSNFDQEFTSVTPVLTPVQSVLSQAMQEEFRGFSYTADFA
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Phosphatidylethanolamine produced by PSD2 is insufficient to completely provide the PtdEtn pool required by mitochondria under respiratory conditions. PSD2 is also involved in the PtdSer transport step to the site of PtdEtn synthesis on the Golgi/endosome membranes. Required for normal heavy metal resistance.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The C2 domains have an essential, but non-catalytic function (Probable). Both C2-1 and C2-2 facilitate interaction with PstB2/PDR17 and are required for lipid transport function.
Sequence:
MRIIKGRKRGKNKKPTLILKIHVIQAENIEALKTFNCNPVCFVTTNTFYSQKTNKLKNSNTHWNQTLRIKLPRNPTSEWLRIIVYDALPTGAPPTTPSRPRTTTANTSSSTLSNSGLSSHSHSSRNLNVTSKGNQTSTSINSVSSSATPAPSHSSSSLSTTGPGSTHKNRINSYLYLGEAKISLLDLFKRKDTTTSYKFSIEAQRYHLYDMKGGKDQDSLNCNFLVGDILLGFKLECNVKRTPTFQAFNAWRNELNTYLGRIDRNKARMRSSSSLPPPLEDMLSNSSAVSGNEIRREKPYSDTDLAHDEEVNAEDEIDAEESIEDMNSSGSICTERRYDIDNDTIFDSISEVVSLNDEELDILNDFEEADHPNVPDINVHDIDEDTRISLSSMITALDEYDIVEPEDVAKLPAVSENDITSVDDEESENQQESDEEFDIYNEDEREDSDFQSKEYIGSRLLHLQRGKHNKSYANYLYRRAKSNFFISKKEHAMGVVFMHIGAIKNLPALRNRLSKTNYEMDPFIVISFGRRVFKTSWRKHTLNPEFNEYAAFEVFPHETNFAFSIKVVDKDSFSFNDDVAKCELAWFDMLQQQQHENEWIPYEIPLDLTVEPAHAPKQPVLYSSFKYVSYPFLKKSFWKEAVDTSVNLERLDIIQVMLYLERLGSFTMADSFELFQHFNKSAWAGQSITRSQLVEGLQSWRKSTNFKRIWTCPRCMRSCKPTRNARRSKLVLENDLITHFAICTFSKEHKTLKPSYVSSAFASKRWFSKVLIKLTYGKYALGSNNANILVQDRDTGIIIEEKISAHVKLGMRIIYNGKSPESKKFRSLLKTLSIRQGKKFDSTASAKQIEPFIKFHSLDLSQCRDKDFKTFNEFFYRKLKPGSRLPESNNKEILFSPADSRCTVFPTIQESKEIWVKGRKFSIKKLANNYNPETFNDNNCSIGIFRLAPQDYHRFHSPCNGTIGKPVYVDGEYYTVNPMAVRSELDVFGENIRVIIPIDSPQFGKLLYIPIGAMMVGSILLTCKENDVVESGQELGYFKFGGSTIIIIIPHNNFMFDSDLVKNSSERIETLVKVGMSIGHTSNVNELKRIRIKVDDPKKIERIKRTISVSDENAKSTGNVTWEYHTLREMMNKDFAGL
The following text describes a protein:
Function:
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Early endosome membrane. Late endosome membrane. Membrane; Multi-pass membrane protein. Recycling endosome membrane. Synapse, synaptosome.
Sequence:
MSGAWKARQTPVEGCGAGLRIPGEAAPAPAAALGALPRLLPRDPRRPTHPPSFPGPPLLPPSSLVGPGAAEHGGGRRSRARLPRKTTGLAGRQARCAIPGGGGNGGGDRGDCSGQLSPIPCAPASRRAAKQPAVPGSPSPRAHGRAQGTIAATAMGKPARKGCEWKRFLKNNWLLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVAEIDRTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPRDPETNMTEESFTAVMTTAISKNKTKEYKIIGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITIRDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
The following text describes a protein:
Function:
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy and pyroptosis, but not apoptosis.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Nucleus outer membrane; Peripheral membrane protein.
Sequence:
MADAFSLQRVLETFRSSLSENKEVYIKYYIAGWQELVSFMNSLGNVFSFISKDVVSKIQILENFLSGENGSNYVTIQSMVKYELENDLVDLTKRGSHPESGCRTLLRLHRALRWLELFLERLRTSTEDSKTSVMCSDAYNESLANHHPWLIRKAVGVAFCALPGRETFFDVMNAGDHTQVVALLGESLPLIAEVYQITEDLYAKNNLLELP
The following text describes a protein:
Function:
Uptake of uric acid.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYLLAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIAAGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYGSLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPFFQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYRAEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALASAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIFAEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MSKMRLSAHGATATFATPNSHAWRRSTSYSRDSTPLPSQFVHASSCTRMEAWIRCTALATSNLALPADKTRYLSAAIRHAQCRPSNTRTSSLTRPNVRYASQSCADRQEAALNTSPSTRTKRRTTVAYDSLASSVLGEDGQPLPALAALTPAVRKRSRSKSRTKPYTDAATCAEASAQETESIRWPPLAQSVLDDMARFPSTILLTRVGGFYESYFSQAPQLASMLGIKLANRRWGGQDVPMAGFPVFQLEKYLKILVLDKRLLVAISEEFRPKDDKVGNATEITRRVNRVVSPGTLIDEKFLDPFVNNFIVAVSVMHEQDKVRYGLAWLDVGTADFNTAVCEDFKTLRDEIARIGPKEIVIDAGTIDASEAQEGVVQQVIAERVQEKRIKLDIRELVTDSSIYISHFHPPPPSPPATKPVETHQESAAQDTFAPPTSSLDAVETATVHALLSYLRTRLLDHETASTLTSLSLSRPLHQPLDSIMQIDAHTLCALEIRSTGRQGSTRGSLFSVLRRTVTRGGTRLLQQWLCNPSTSISTINARFDVVELFLRRKALREDARSILRSGAGDVSRVLQKLMTRRNDEQDLLEVRDAIGAMDRLKRLMQSEVEFMACEEKERQTLENLVSKFHDLTDLASRLGDAIDERVIALRLERQETLAAEVQDIAAASSASDGSRAQIRNLGSGTPTRAAAASKGVSAAKRGGNSSVAADHVDPDDSCSLWGDDFEHLIRPASSKALASLTRSHRALRRTARRLELDFQQAYASDNVTLRYVLGQGYVVHSRGKALASTPNVALPSTCTSSMEDLSVHIAGKNRSTHTYYCATWTALGSRLDRLCKEMQALESIELEALRQHVLEQAAQLRTNARLLDQIDVLSSFSQASEEYHLVRPIVDDSTDIDVAGARHLSVEMGLLERGRLFTPNSLNLSDGGVHIITGPNMGGKSTFLRSIALLTILAQCGCFVPCSHPSRLGLVDRIFTRIGAQDDVFRDRSTFMVEMCEVGEILNRATHRSLVIADEIGRGTSNLTGIAVGFATLECLWQRRCRTLFATHFYEICDLVKDQAWPRVEFWSTDVHHTTHGSLVYQHELKKGVNTNSYGLQVARLANLPEHTLELASTTLAKLKARTRGA
The following text describes a protein:
Function:
Required for correct xylem specification through regulation of the lifetime of the xylem elements. Prevents premature death of the xylem vessel elements.
Sequence:
MGEAVEVMFGNGFPEIHKATSPTQTLHSNQQDCHWYEETIDDDLKWSFALNSVLHQGTSEYQDIALLDTKRFGKVLVIDGKMQSAERDEFIYHECLIHPALLFHPNPKTVFIMGGGEGSAAREILKHTTIEKVVMCDIDQEVVDFCRRFLTVNSDAFCNKKLELVIKDAKAELEKREEKFDIIVGDLADPVEGGPCYQLYTKSFYQNILKPKLSPNGIFVTQAGPAGIFTHKEVFTSIYNTMKQVFKYVKAYTAHVPSFADTWGWVMASDHEFDVEVDEMDRRIEERVNGELMYLNAPSFVSAATLNKTISLALEKETEVYSEENARFIHGHGVAYRHI
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MSEAGEEINGDSLKENTQPLREDLISTAVKFLQNPRVATRPRSEKELFLQRKGLNHAEISAAFEASGMKETKSEGGVGHYSSVKVAQLHEYSRSLAPVATSKWSIIRDILNASVLIAGAAYSLHYLYRQFIEPFLFGHKKKKSLADTVEEMNKNLTCLVGDVSAAVQNLSDTVATLRSKQHEQSELKELKAEVTSLKAILLGRRQFPAPPAIVTGPPSIPPWQLSATGGAKQDLRAEQSNKNNQSDGISLSSSPEIISVEDMQTNSSSMVNAGLSSVLPARGPSESSESNSAEIVEMGVSGASGEEDTD