lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor of HOXB13 gene.
Miscellaneous:
MISCELLANEOUS: Imprinted gene expressed from the paternal allele in blastocysts and in embryonic tissues early in development. Imprinting is lost in somatic tissues after 7.5 dpc; MISCELLANEOUS: [Isoform 2]: Incomplete sequence.
Subcellular Localization:
Nucleus.
Sequence:
MERYLPVSKKRNSSSSLEKITGSANGNGTLYSEEDTNLEENDFSWGDYLEETGTRAVPHVSFRHVEISIRSNFQPGMKLEVANKNNPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKDKYSDWTDFLIRELTGSRTAPANLLEGPLRGKGPIDLITVDSLIELQDSQNPFQYWIVSVTENVGGRLRLRYVGLEHTESYDRWLFYLDYRLRPIGWCQENKYRMDPPSDLYYLKLPFEWKCALEKALVLAAESPLPMEVFKDHADLQSHFFTVGMRLETLHISDPFHIYPASVTKVFNSKFFQVAIDDLRPEADKPTMLCHADSLGILPVQWCLKNGVNLAPPKGYSGQDFNWVDYHKQRQAEEAPHFCFKNAFSRGFSKNMKLEAVNPVNPGEVCVATVVSVKGRLLWLHLEGLETPMPDIIVDMDSMDIFPVGWCEANSYPLTTPYKASSKSKRKTVHFKMEKQLLSPVPIEKIPHELCLLPPQMDSPVGAINAKYCCPQLFVNHRCFSGPFLNKGRISELPQSVGPGMCVLVLKEILTLITNAAYKPGRVLRELQLVEDPEWNSQEEILKAKYGGKTYRAVVKIVRTADQVMNFCRQVCAKLECCPNLLSPVLISETCPENCSVHTKTRYTYYYGKRRRVIQSSLRVSNIETPPKSTRRRKRRKSVYVQKRRKSAIVVPAGVPAGVPAGVPEDIPAGIPEGIPASIPESIPEGIPESLPEAIPESIPKGSAQKTEQEKRETLDTARKKTGYHGPAYQTDTSAAQVPFARPRRAVTLRRNSEALKRPPVERARRVRTVPTTASSNNRVKGPLVRIVKPEDSSQSDEEKLILESNPLEWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKVAFYAQYAS
The following text describes a protein:
Function:
Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Subcellular Localization:
Nucleus.
Sequence:
MTTAPPGGSLIDEPCASFFDTLLRESSFELEKAEPFARSREEIASVAVVGGGDPSDLGSLPHSVPSPKLANGHGEIDAGPPLRSCLTRPEPRSALAAQVVKIEEEEEDEEVAIIADPGDAAAGSPSCSSRAAADEVARPMQGLGEVGPAPFLRKMYEIVSDPITDPVVSWSSSRDSFVVWDPHGFSKQLLPRYFKHSNFCSFVRQLNTYGFRKMDTDRWEFANRGFQEGKKHLLKNIRRRRKLSEHTKTSNSTVASDYPEAGKEAELEMLKKDQEALKSEILKLREEREHSQHEINQVAERVRYAECRCQRMFLLLSKATESSNFVHLIQERRQKRELEACESRKKSKLQSPDSEVTKCLLEVMDHKIQNPNVDCPRVGDDLAQMESRPNNVAPVDFQTVQMHNPWPPPMGGGDFRAVQGQTPDWMAGASSSDLPSVFHEMSEKLPGDNVVVGDNVMDVEAGELAMDDTGIYLELEGLIEKSFGWSDYTSELRELAVGLTP
The following text describes a protein:
Function:
Binds different dipeptides. Probably bind only L-amino acid containing dipeptides.
Subcellular Localization:
Periplasm.
Sequence:
MRKILPLRAWLAAGLILGSPFSHAASNLVFCSEGSPAGFDPAQYTTGTDYDATSVTLFNRLVQFERGGTRAIPALAESWDIGDDGKTYTFHLRKGVKFHSTDYFKPTREFNADDVLFTFQRMLDKNHPFRKAYPTEFPYFTDMGLDKNIARVEKLDEHRVKFTLNEVDAAFIQNLAMDVASIQSAEYAGQLLEAGKPQQINQKPIGTGPFILSRYQKDAQIRFKGNKDYWKPEDVKIDNLIFSINTDAAVRAQKLKAGECQITLNPRPADLKALQEAANLKVPSQPGFNLGYIAYNVTHKPFDQLEVRQALDMAVNKQAIIDAVYQGAGQLAVNGMPPTQWSYDETIKDAPFDPAKARELLKKAGVAEGTEITLWAMPVQRPYNPNAKLMAEMIQADWAKIGIKARIVSYEWGEYIKRAHAGEHDAMLFGWTGDNGDPDNWLATLYGCDSINGNNVSKWCDAAYDKLVKAAKRVSDQDKRSELYKQAQHILKEQVPITPIAHSTVYQPMSKSVHGFKISPFSRNAFYGVANQP
The following text describes a protein:
Function:
Active toward triacylglycerides with a preference for esters with C8:0 acyl groups; barely active on C18:1 or C18:4 substrates. Active against p-nitrophenylesters with fatty acid chain lengths from C6 to C18.
Subcellular Localization:
Secreted.
Sequence:
MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIGGASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKVDIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIYSSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN
The following text describes a protein:
Function:
Required for cell specification of the RIA interneurons.
Subcellular Localization:
Nucleus.
Sequence:
MSNPTDNNSATSSITPNFSAFSSFTTYKPSDSFSSFESDSSPSKSSSSRKNRDKIADKKQRRNRTTFTTFQLHALEAAFDKTHYPDVYARETLAAKVQLPEVRVQVWFQNRRAKFRRQEKQDCQGEEKHSLKDTMPSWSWMSENKTDTPPMLPPANTLSSTHNNGISDEFFKTSEGKEVYGFPFAEYGTPADNTHVSKTGNVFHLNFEDSDKKSMKKESPQTPSTSSPFISEYHPPFIPYYIPNQSFSNAFNQYPMPFPYPIHFEPPQLTHSQENC
The following text describes a protein:
Function:
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals (Ref.1). The recombinant toxin selectively inhibits the fast inactivation of hNav1.7/SCN9A channel (EC(50)=136.7 nM). Is potent in inhibiting the fast inactivation of hNav1.7 and has little effect on the steady-state inactivation. In vivo, intravenous injection into mice induces muscle contraction, leading to severe paralysis and death (Ref.1).
Miscellaneous:
MISCELLANEOUS: Negative results: has very weak activity on hNav1.5/SCN5A sodium channels (EC(50)=31.9 uM).
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
LKDGYIVDDVNCTYFCGRNAYCNEECIKLKGESGYCQWASPYGNACYCYKLPDHVRTKGPGRCN
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MATRAKKSVKRKSGKKAAKKATKKAVKALARKAAKKVKKTKKAAAKKGVKKSAAKTARKAGKKAAKKQVGAKKAVKKAAKQPAKSPTKKAPAKKAKVTAAAVTAAPTPVATPPKAVKPNVSKPKAPRAPKPVAAPQAAVPAAAPARDNVFYITTAIAYPNGNPHIGHAYEAIATDTLARFARLDGKDVFFLTGTDEHGLKMIQTAQNEGLTPSALAARNAARFKAMDERLNVSFDRFIRTTEEQHHRSTQEIWRRMEANGDIYADTYAGWYSVRDEAYYAEDETRLNDDGVRLGPQGTPVEWVEEKSYFFRLSAYQEKLLKLYTDNPDFIGPDSRRNEVVSFVKGGLRDLSISRTTFDWGVKVPGDEEHVMYVWVDALTNYITGVGFPDESDKNWRYWPADVHIIGKDIIRFHAVYWPAFLMSAGIPVQKRVYAHGFLFNRGEKMSKSVGNVVDPFNLADQYGVDQMRYFFLREVPFGQDGNYNHEAIVARINADLANDLGNLAQRSLSMIAKQLGGVLPEPGEFSDNDKAILAMADGMIAASREAMATQQIHHWLNAVWAVVAEANRYFAGEAPWALAKTDPARQKTVLYVTAEVVRQIAILAQPAMPTASGLLLDSLGVPGGERNFAALGGAKRIAPGSTLPAPTPAFPRYIEPAA
The following text describes a protein:
Function:
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.
Sequence:
MASVNSSHDDDDDGAVDSINITPLVDVLMVVLVMFILTATAQVAGIQINLPKASATVALSQPKTKAISVNDAGQVFLDAYPVTLPELEDRLRTEKALNPDFPVVVRGDATVQYQKVIEVLDLLRRLELSQVGLVTGKPT
The following text describes a protein:
Function:
Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria (By similarity).
Sequence:
MSGELSNRFQGGKAFGLLKARQERRLAEIDREFLCDQKYSDEENLPEKLTAFKEKYMEFDLNNEGEIDLMSLKRMMEKLGVPKTHLEMKKMISEVTGGVSDTISYRDFVNMMLGKRSAVLKLVMMFEGKANESSPKPVGPPPERDIASLP
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKSIKRFALSAMGAAMLLVLTGCVNVDKTTGQPTGFIWNTIGAPMAEAIKYFATDKGLGFGVAIIIVTIIVRLIILPLGIYQSWKATLHSEKMNALKHVLEPHQTRLKEATTQEEKLEAQQALFAAQKEHGISMFGGVGCFPILLQMPFFSAIYFAAQHTEGVAQASYLGIPLGSPSMILVACAGVLYYLQSLLSLHGVEDEMQREQIKKMIYMSPLMIVVFSLFSPASVTLYWVVGGFMMILQQFIVNYIVRPKLRKKVHEELAKNPSKASAFSTPSGRKDVTPEQPTAITSKKKHKNRNAGKQRSR
The following text describes a protein:
Function:
Binds directly to 16S ribosomal RNA.
Sequence:
MAPRKPSKKVGPQKRPSAEKRVITSKKKQLRNQSFKSKVRTILKKFELAVQSGDVESISAGLRSVYSIADKAVKRGIFKKGKADRVKSRTSERACPAA
The following text describes a protein:
Function:
Probable ligand for tyrosine kinase receptor let-23. Essential for vulval induction, where it acts downstream of the synthetic multivulva (synMuv) class genes. Probably by activating let-23, phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade, plays a role in ovulation by promoting gonadal sheath cell contractions and spermatheca dilatation during ovulation. Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, by activating receptor lin-23-mediated signaling cascade; [Isoform a]: Essential for vulval induction; its activity on vulval precursor cells is partially dependent on rom-1; [Isoform c]: Essential for vulval induction; acts independently of rom-1.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRKMLLFCILLLFMPQFTVSESCLPSWFRQERSAPEQLQSAENAAENSGSVPPDTSRNSLETNEIGDAPSSTSTPETPTETTISEAGDDEKRTEEVAKELIEKEAEYEGEYEDEKVDEEVEEALKYNEDATQDATSTLKPAVRKEIEKLKEAKCKDYCHHNATCHVEVIFREDRVSAVVPSCHCPQGWEGTRCDRHYVQAFYAPINGRYNVRLSTMSSTAQLLVQQSSTSAIPAFAFLIVMLIMFITIVVYAYRRMSKRSDDMTYTMSHMCPPEAFNVLKTPNGRHIPVHQIPSCSYTIPTPGTVPPNISSTPGSRIPTRQQAIRNNEQARNNFFSILRSQGTIPSRSINDDDTPKHYKSVPRVEVSAINYSGHIDFSTVSYQSTESEVSKASVTCPPPAHTVINIELDSADTNFRSPSRSSGEQGSPATCEPMIRHT
The following text describes a protein:
Function:
Involved in the biosynthesis of tyrosine. Has a weak prephenate dehydrogenase activity.
Miscellaneous:
MISCELLANEOUS: Unlike TYRAAT1, TYRAAT2 is composed of a single catalytically active domain.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLLHFSPAKPLISPPNLRRNSPTFLISPPRSLRIRAIDAAQIFDYETQLKSEYRKSSALKIAVLGFGNFGQFLSKTLIRHGHDLITHSRSDYSDAANSIGARFFDNPHDLCEQHPDVVLLCTSILSTESVLRSFPFQRLRRSTLFVDVLSVKEFPKALFIKYLPKEFDILCTHPMFGPESGKHSWSGLPFVYDKVRIGDAASRQERCEKFLRIFENEGCKMVEMSCEKHDYYAAGSQFVTHTMGRVLEKYGVESSPINTKGYETLLDLVENTSSDSFELFYGLFMYNPNALEQLERLDMAFESVKKELFGRLHQQYRKQMFGGEVQSPKKTEQKLLNDGGVVPMNDISSSSSSSSSSS
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MKNPIIDNIPCVLLAGGKSSRFITNNIQTNKALMPLKSYSSLLEYQYTRLLKLFKKVIISTKKSYELNAPYLLEKESDLFSPLFGIHNAFLTLQTPYIFFIPIDTPLVSFESIKALCGIKNFSVTYAKSPTKEHYLISLWHQNTLNALIYALKTQNYRLSDLVKNTSSVAINFDKEEEFLNLNTLKDYELAVQILKKRANG
The following text describes a protein:
Function:
Virulence factor acting as a pro-inflammatory protein that induces the secretion of the pro-inflammatory cytokines TNF-alpha (tumor necrosis factor-alpha) and IL-8 (interleukin-8) from human macrophages, as well as enhanced translocation of the transcription factor NF-kappa-B complex in macrophages. Is a kinase capable of autophosphorylating itself at a threonine residue near the N-terminus. Also leads to enhanced phosphorylation of the NF-kappa-B p65 subunit (RELA) at 'Ser-276' in human epithelial cancer cells; its kinase activity is required for this enhanced phosphorylation that up-regulates NF-kappa-B activity, but it does not directly phosphorylate this protein. Thus, the kinase activity of CtkA may play an important role in the induction of host inflammatory responses during H.pylori infection.
Subcellular Localization:
Secreted. Host cytoplasm, host cytosol. Host nucleus. Note=Translocates into cultured human cells. When examining the cellular location of the transiently expressed CtkA after 0, 12, 24, and 48 hours of transfection, the transiently expressed CtkA translocates from cytosol into nucleus in a time-dependent manner.
Domain:
The C-terminal tail (residues 301-325) is not required for the kinase activity and for translocation into human cells.
Sequence:
MPTIDFTFCEINPKKGFGGANGNKISLFYNNELYMVKFPPKPSTHKEMSYTNGCFSEYVACHIVNSLGLKVQETLLGTYKNKIVVACKDFTTHQYELVDFLSLKNTMIELEKSGKDTNLNDVLYAIDNQHFIEPKVLKCFFWDMFVADTLLGNFDRHNGNWGFLRASNSKEYQIAPIFDCGSCLYPQADDVVCQKVLSNIDELNARIYNFPQSILKDDNDKKINYYDFLTQTNNKDCLDALLRIYPRIDMNKIHSIIDNTPFMSEIHKEFLHTMLDERKSKIIDVAHTRAIELSLQHKQAHSNPYDNADDLDNSNEYTPTPKRRR
The following text describes a protein:
Function:
Receptor of ubiquitinated protein targeted to ubiquitin/proteasome-mediated proteolysis (UPP). Relatively weak affinity for both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains with a slight preference for 'Lys-48-'linked chains of three or more ubiquitin units.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MRITVMTAGEQIITLDVDSQETVENVKALLEVESNVPIQQQQLLYNGNEMGNSDKLSALGVKDDDLLMMMVSNASSGSATSAAGNDLGMNPDGSALNPAAFQQHIRGDSNLMGQLFQNDPELAQVISGSDLNKLQDVLRARHRQRSVLQRQKEEELALLYADPFDVEAQRKIEAAIRQKGIDENWEAALEHNPEGFARVIMLYVDMEVNGVPLKAFVDSGAQSTIISKSCAERCGLLRLMDQRYKGIAHGVGQTEILGRIHVAPIKIGNNFYPCSFVVLDSPNMEFLFGLDMLRKHQCTIDLKENVMTVGGGEVSVPFLQEKDIPSRFLDEERVPNDASSSGATVPSGFTEKKNNTVANPTSQQPKRQNTSEGPEFEAKIAKLVELGFSRDSVIQALKLFEGNEEQAAGFLFGG
The following text describes a protein:
Function:
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
Subcellular Localization:
Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (By similarity).
Sequence:
MSSSITMSEPRLNWDVTPKNGLKAFFSPENYKDHSMAPSLKELYILSNRRIGENLSVSASSVENEPAVSSATQAKEKVGMILLPKPRVPYPRFSRFSQREQRTYVDLLAKYAKLPSSSKTVGTNTNEYLQYLDMKKHVNEEVNEFLKFLQNSAKKCAQDYNMLSDEARLFTEQLLRACIEQVKKYPEFYTLHEVTSLMGFFPFKTEMGLKLEKTLLVLGSAKFVKTAFPSMPVKLQLSKEDMSSIETPQQKAEVMHCDISKDPNAEKLVSRYHPQIALTSQALFTLLNNHGPSYKEQWEIPVCVEMIAVEGSKPVKVIYINSPLPRKQMTMRERNQIFHEVPLKHIISKNTSVPVSAVFMDKPEEYTSEVDMPTEAGECRKIETLENLDMDFDGDVTELETFGVTTTSPPRSPSSESDSSAPLMTDVHAVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATPNITDDSRSLCQILMKQLQKEKQLFSGVEGGPEGCKNKDDQGLEPCGEEVPSANAKSLTQDNEVHRTEGISKESDVGVLCTNDERQGGQGNANNPNNTATASEAAESEKGIPCGSDTDEDCLIIDTESRSCDGKTADLGSRPNSSAQASAGNQATTTVSEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPVSRKVPELPLTNSEESKQPPASEQPSAALDAAPWPKSSWPSAFQKPKGRLPYELQDYVEDTSEYIAPQEGNFVYKLFSLQDLLLLVRCSIQRVETRPRSKKRKKIRRQFPVYVLPKVEYQGCYGVEALTESELCRFWTESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYKTSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVPLDPSYLLPYHIHHGRVPCTFPPKPLRPAAQAKVGGTRMPTRNHRNPVSMETKSSCLPVQQVENEGVARNKRKIM
The following text describes a protein:
Function:
Cell-counting factor that limits the maximum size of the multicellular structure during aggregation.
Subcellular Localization:
Secreted.
Sequence:
MNKLISLLLVCLVAIALVNADCAIDFDSDTVNSVTSSDWSCLAASNDRVIMQVFSGGYGYTSGIASAVQGAQAAGISTIDLYAFLCNQCSGNSPSSSAIQSIVSQLQNDGVSYNMLWIDVEQCDGCWGDLGDNAAFVQEAVETAQNLGVNVGVYSSIGEWSQTVGNLSGLGVDLWYAHYDNNPSFSDSSFYEFGGWTSPTMKQYAGNGNECGVSVDMNFFGSGTCSASTGSGSGSSSGSSSGSSSGSSSGSGSSSGSGSSSGSSSGSGSGSSSSGSGSGSGSSSGSGSSSGSGSGSS
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MVHYKLTYFNARGLAEISRQLFHMAGVEFEDERINEEKFSQLKPTFPSGQVPILCIDGAQFSQSTAIARYLARKFGFVGQTAEEELQADEVVDTFKDFIESFRKFVIAVLSGESEEILKNIREEVIKPAVKTYTAYLKAILEKSSSGYLVGNELTWADLVIADNLTTLINAELLDIENDKLLKEFREKIIETPKLKEWLAKRPETRF
The following text describes a protein:
Function:
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
Subcellular Localization:
Cytoplasm. Lysosome. Lysosome membrane.
Sequence:
MEESDSEKKMEKENVGSRMDPPIGEPEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRLHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR
The following text describes a protein:
Function:
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAGLEELQADLQEIERLLEQSTRDRVKKALTLEKGRIQTEITDSSETAVSSAQNGVEEPEPSPDDAKKEQEPSPDDAKQTVKRRAPPPPGQATKHKTKITSYGWDQSDKFVKIYISLNGVQALPKDNIEVNFGEKMVDFLVKDLGGKNHNLLINTLLLPITSVSYKVKRDMVTLLLRKKETQNWECLTSVEKKSKDKKSPKMNSSGDPGDSIMTMMRQMYEDGDDEMKRTIAKAWTESRDKQQAGMGGMGGMGGMGGMGGMAGMGGMAGMGGMGGLGGMGGLGDMP
The following text describes a protein:
Function:
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Nucleus. Mitochondrion intermembrane space.
Sequence:
MDALEEESFALSFSSASDTPVFNEYISLVEKYIEEELLERIPGFNMAAFTTTSRHHRAEAAGDVLDMLLTFADFLAFKEMFLDYRAEKQGRGLDLRSGLVVTSLCKSQNVGSLHCANPKSLHQLPRVTCGPGPTARQWDLSGRCQPNSLEEALANVTIHVGKTDPVLQLINVKY
The following text describes a protein:
Function:
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Sequence:
MILKEGEVVFEVPDKLTVTKKDEVFYNPRMKTCRDISIAVIQAFLNLYHKRDKFYIADALAGSGIRGLRYAKELEFNGELKVFLNDINPKAYEKIINNAKLNEIENIDVFNEDANTFLSKHFRFFNVVDIDPFGSPAPYVEQAIRALVTRNGLLCLTATDTAALCGRSKKSCLRKYLAYPLFGRDCHEFALRVLVGYVMRMATKYELALKPVFCHATDHYVRVYLVTDRGAKRADKVFEMLGYVKDVNGIKIIKKFEEGYEKGFAGPLYIGNLYDKALVEEALKIAEKREFSERVLKILNAIKGESAINQVGCYDTHQIGKMLKISVPPMQDIINKLKEMGFNAVVTHYNPKGIKTDATLKNVIEAIYQCTKIR
The following text describes a protein:
Function:
Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Is involved in the utilization of arginine as a nitrogen source, via the AST pathway, and also seems to play a role in ornithine catabolism.
Sequence:
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMHYGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNTINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
The following text describes a protein:
Function:
Transaminase converting glutamate 1-semialdehyde (GSA) to 5-aminolevulinate (ALA). Involved in the biosynthesis of tetrapyrroles.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAATLTGSGIALGFSCSAKFSKRASSSSNRRCIKMSVSVEEKTKKFTLQKSEEAFNAAKNLMPGGVNSPVRAFKSVGGQPVVMDSAKGSRIRDIDGNEYIDYVGSWGPAIIGHADDEVLAALAETMKKGTSFGAPCLLENVLAEMVISAVPSIEMVRFVNSGTEACMGVLRLARAFTGKQKFIKFEGCYHGHANSFLVKAGSGVATLGLPDSPGVPKAATSDTLTAPYNDIAAVEKLFEANKGEIAAIILEPVVGNSGFITPKPEFIEGIRRITKDNGALLIFDEVMTGFRLAYGGAQEYFGITPDLTTLGKIIGGGLPVGAYGGRRDIMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKRLSQPGTYEYLDKITKELTNGILEAGKKTGHAMCGGYISGMFGFFFTEGPVYDFSDAKKSDTEKFGKFFRGMLEEGVYLAPSQFEAGFTSLAHTSEDIQFTIAAAEKVLSRL
The following text describes a protein:
Function:
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSKHRHSKDKLYVTYSEHMLERGGKKENKGTPLTRLPFDHCSLSLEPFKNPVCTSEGHVFDIVNIVPFIRKYKRNPINGQALRTNDLIQLKFHKNDKGQYHDPISFKVFTDHTKLVAIKVSGNVFTSDTIEELNRKPKFWKDLISGEPFTYKDIIVLQDPKNIESRTIKNFDFLKNNLKLDQSTEDDVYVNLNDSGKRIMEMAQEQNVNRQKEQKDREKQSFEEIEQIKKKVKEQMESNQLSVKEFLELSSKSGDFVSERYATEHDSVSVTSTQMTLKTKPLGQVQYRNMNEDEIRKLLYERIRKSGQKGYVQLITNYGNINFELHCDLVPMTCENFLELCEKGYYNQTKFHKLIENELLEGGDPTATGYGGESIFGKPFRIEINNLLSHSKAGMVSMGNLGATHQTSHFFITLAECKKYDSKYAVFGEVVGGFQTLYQINKLPTNMWQRPEVTIKLKELKVIKNPFRDMIKIMLQEKEVEKEQKLQDKEKERWLDDEGFSLPTRVSTATQIKGLGLASNLIQQFSTQEQQKKQLKQFSFDSWL
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Associated with the outer doublet microtubules (OD).
Sequence:
MAEGIGTFGTLSRDVLEERLMEARRTYRLNMGYAGLKQLPPGFVELVKKYNPHITELELSSNDLTDLPDELEEFRYLRILRLKYNQLKRIPAVVYRLPQLMVFDASGNRIQKVDDAIGHLSLLKELDVSGNEITTLPESLSTLPKLEVLQVENNRLELLPESLGELPGVIKMDLSTNNLRYLPASMGQLKKVQRIDVGNNLLTKVPPSMGHLKTLKEFNLRYNHLDDRYKAKVEEGLSKFLAFLREEEERERLEEIERLKPIGTPVGAYLEYRCKAEVGQVVKTDMGETTVDNRCWIRTGHTLTQVGSMLLIFGGQLQKDGSTTNDLFWMTMDRMEWHNQPCKGEKPPPRYNHAACYDEENNRLVVFGGRTAERKRLNDIYFLDLDSWTWFKPSTEGTAPTPREQAVATFWAGSMVLFGGHAIGGRTNDLFLLDLGAWQWSQPAFSGTAPSPRQACALCIGHGNLLFVHGGRNNFVLEDLHVMDFVSKNWTEIPCEGRVPPPRHSHRITVHRDQLYLLGGLDELGAQSVAMYRVALPAGQQDTYATSKPKWVEWDSELPYNKNRTATLWNGTISIYQLGSNTLGRVNDDDAEKGLDELRPKNAKRMRVQHTINTAGKMPRSFTQHSAHEARVLQYVQDFQRIFEELYPYRRPLYLTPRNECGVPKFVCTSLRPSQLVYTELYDLDGASQFVADFLSYEPLEDPLHPPDTLPSPMSALEWRAGDSFDMATVLASMLLGVGYNAFVVLGYAPGPVVQNDQRNTDLAATRTGAGAEEEEESGPCKFVHAWVMVLPGKREVTEAMFIEPSAGRKDVSYDLSDPTKWEPVFEDRGMRSRADGNADESETEGGGGLDDGEGVEAEVVPDIPPSWVPKLTIPRDAFDMRCPRHEIFARFGDCSRWDGMVERLVLYADEERTVVTEIRETFTRRRDKLRERRVYPQKDTTIEHFNRGSVFALKDILTVKNDRRGRKVIQYYTGRDDRLIYISATYAVDPLAPRPQPSALLEEYSSLLVAEKDCLQWVRDGEWEISEIIRTRTNQEQNITLETPYYDIVRIKAEESEEVREKALKALKDRLIERANIIQARLDEESAALAKRQQTFHRDRDQMSAAEEEDYERQTEESMFRIHILERRLRRHEEQALHKYYELDAKLRADGRLAALLN
The following text describes a protein:
Function:
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSQTNDKPALHLVPSFYGVYILKSIPKPRSTYIGSTPDPKRRLRQHNGDLKVGGAYRTKKDGSRPWNMVVLVYGFPSRIAALQFEHSLQHAYQTRHIDNDARITSSSRQSSIHSKLANIRLLTTSFDKMSLKIAIFDEEVYRMWIENKHKIECSVPCTLFKFEEFCDSIKEIDIEDAKNVLLSKQLECMECRVSIDYFQDNTPNISSRQELSNYLSKGNYPLIGICGDHAFHLSCMARQHGPSMVPKFVTCTTCGQKLDWSDIIKVSTRLRHYVVQDSLHLAITQL
The following text describes a protein:
Function:
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subcellular Localization:
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Sequence:
MASVNWADDRAARKKFPPPSFYMPLLVSSDKAPYRVIPRNLVPIGKGNKDEQIGYWNVQERWRMRRGQRVDLPPKVHFYYLGTGPHKDLKFRQRSDGVVWVAKEGAKTVNTSLGNRKRNQKPLEPKFSIALPPELSVVEFEDRSNNSSRASSRSSTRNNSRDSSRSTSRQQSRTRSDSNQSSSDLVAAVTLALKNLGFDNQSKSPSSSGTSTPKKPNKPLSQPRADKPSQLKKPRWKRVPTREENVIQCFGPRDFNHNMGDSDLVQNGVDAKGFPQLAELIPNQAALFFDSEVSTDEVGDNVQITYTYKMLVAKDNKNLPKFIEQISAFTKPSSIKEMQSQSSHVAQNTVLNASIPESKPLADDDSAIIEIVNEVLH
The following text describes a protein:
Function:
Transcriptional repressor of the azlBCD operon involved in branched-chain amino acid transport.
Sequence:
MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKNLVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTLTGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM