lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells. At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole. Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure.
Sequence:
MEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCETRWLQLFNLVEKQCQEQIVAQQEQFHNQIQHIQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDAYTQISDLKRMISKLEAQVKQVEHENMLSLRHNSRIHVRPSRANTLATSDVSRRKWLIPGAEYSIFTGQPLDTQDSNVDNQLEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSDTPIMRALKELDEGKIFKNWGTQTEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLNSASQRSSSLPPSNRKSSTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPIRFDILLDDLDTVPVSTLQRTNPRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPVPNGVKKVSVRTAWEKNKSVSYEQCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLERINRELGSVRMTLKKFHVLRTSANL
The following text describes a protein:
Function:
Part of an ATP-driven transport system YfeABCD for chelated iron.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNMLFSLISEPFAYPFMQRAIVAAIVTGVVCAILSCYLVLKGWSLMGDAISHAVLPGIVLAFWLGIPLVIGAFVSGIFCAVATGYLKENSRVKEDTVMGIVFSGMFAFGLVLFSRIDTDQHLSHILFGNMLGISLTELKQTLWIAGFTLLVVLLKRKDFMLYCFDPNHARVIGLPVKFLHYGLLCLLALTIVASLQAVGVILVIAMLIAPGIIAFMICRSFDQMLVVATLVSVVACVLGTLISFHIDGATGPCIVIIQALFFVVALIYNHIKPIKDRKMAPLTKAVNPENTAPSNLP
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MEFVVNLVTQYTVQRHEDDFIDRLNFQYSAYVFALSALVIGYHTYFGRAISCWTPAEFKGGWNEYTTDYCLIENTYYVPLEDPNMPPERYREEKELSYYQWVQFILVFLAFLFYLPYLYWSTVNWWSGLQVKAVVDVACNLDKTDVGKRNAGIEKIASHLKKYIDRQGRKSPIPLIPNIIGRNWVSFNYILTKFLFLVNLIAQMFLIHFFLGFDLDDFISLRVGFGSNWIANGIFPRQTMCDFEIRKKGSIQKYSVQCVLSMNMLNEKVFLALFYWIIALFFLTVWNLFTSFQHFFHASSRKEFVRRMLSAGGHTLTDGGHGEEKVPLVERPDGTYSNDYNRVLSINPDIVVVLHLIAKNAGDNVCQNVVDMLFQKLSEKSQ
The following text describes a protein:
Function:
Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGNVVQERQGALAQGEVLPRPAASQSEGFKQGRSVLNSLVSGAFAGAVAKTAVAPLDRTKIIFQVSSNRFSAKEAYRLIYRTYLKDGFFSLWRGNSATMVRVIPYAAIQFCAHEQYKGILGKYYGFQGKALPPVPRLLAGSLAGTTAAIITYPLDMVRARMAVTPKEMYSNIMDVFVRISREEGLKTLYRGFTPTILGVVPYAGLSFFTYETLKKTHAEKTGRAHPFPYERLVFGACAGLIGQSASYPLDVVRRRMQTAGVTGHTYSTVLGTMREIVAEEGIVRGLYKGLSMNWVKGPIAVGISFMTFDLTQILLRKFQLL
The following text describes a protein:
Function:
Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (By similarity). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (By similarity). Involved in regulation of mRNA splicing. Inhibits SIPA1 GTPase activity. Involved in regulating expression of extracellular matrix genes. Associates with chromatin and may play a role in modulating chromatin structure (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Predominantly located in the nucleolus with a small amount found in the nucleoplasm. Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2. Associates with heterochromatin and euchromatin.
Sequence:
MALAMQSSEFQFAQRLASSEKGVRDRAVRKLRQYLSARTQSDTGSFSQEELLKIWKGLFYCMWVQDEPLLQEELANIISQLIHVVNSLEAQYLFIQTFWQTMNREWQGIDKLQLDKYYMLIRLVLRQSFEVLKRNAWEESQITLFLDILMKEILSPESQSPNGVRTHLIDVYLEELTTVGGAELLADQNLKLIDPFCRIAAKTKDHTLVQTVARGVFEVIVDQSACVPQESVEERKTKEDGSGFPTKALACRKAVSGKKAALDECLRDGVIGSRERDICAALKDSGSPLQFDYKAVADRLLEIANSKSTPPFNRKRLCRLVRKFQDLCEGNGAPLSSAEDNGQRRHKRKRKKLLESEKGDTVSPAAEEDSGGHIHKKKRKKRKRSHFQPDTQNLDAVAVPKVPDSESEPDTAQRQAPCGQACVTEPTAEAVSSIGENSSKPTPVMPIHNKRKRPRKKKLRAHKEICKSTTLPQEDMSKNDAVSGHSQSSAAHISSSEGVQAQKRKRKLGALPDSSSDLPVQKSGTPTSPVEGKDGQTTLPRCKRSQKKTASSTLDPCDPSSQKPAISKKKKKTMKLMSNGVLESNPGQIQALGSNRTLKKPLKTEDDFVKFDTRFLPKPLFFRKAKNSSATRPQGPAGQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGLSRVAFNPEQRPLHGVLKTATSSPASTPLSPMRLPATTPKRRPRAADFF
The following text describes a protein:
Function:
Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis. Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAATASPGAGRMDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKTEGLKGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKALIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALVRIAREEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLLKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG
The following text describes a protein:
Function:
Probably involved in the organization of the actin cytoskeleton.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MQCDISSNRNFMSLESKEIGKMSAKAPIYLKRSTRKGKLRDILSPDMISPPLGDFRHTIHIGSGEGDMFGDISFLQGKFHLLPQSMPGSSTSSPDATPTTSHPDLLNPPPCHPDLLSPLLKNAISLPAIGGPQALSLPQSPPPKPPRLHLDDKPKSTLSEEGGTHSTDVSANNRFTAEEREERILAHAGSILSLHVDLGPSIMDDVLQIMDKS
The following text describes a protein:
Function:
Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (By similarity).
Miscellaneous:
MISCELLANEOUS: It is debated whether the reduction of free aquacob(II)alamin occurs spontaneously or is enzyme catalyzed.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRFLLLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKYDLKTETGPLVMVVSTTGTGDPPDTARKFVKEIHNKTLPTDFFAHLWYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQHFYDTGHADDCVGLELVVEPWIDGLWPALTKHFKSLGGQEDMSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSELQEQNETNKNQPSRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQASVPPSVDPIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADKQAHRVILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEAMKTLATLKQEKRYLQDIWS
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MTLPRLETPLRRSAVGSYQEGVSRMLTPFNDDEAERREARRRTLLQQHHRSSTLESIEDNETIKNCLELYNGNKVSKDNAWNLMLIDSLANLLDHHHKRMSNFKMAGSSLEASSKVYGLRVDSIYLDAMRISAGLSARTLTDKQINAAEDDDGPQGEQATGEGQDSAQQAAKEAAPKPKRQKKPISTVTKNRETLNSRLDTAPLQDPVFGKLNSTVGSINASNRLMHNILPSFDSELRLRTTYNFWNSEESTEEVQDHTTLNAEMEQWPATSLMSTNLMRKLLPHAERSNLRPLHTGYIITSAPNPKSANEKAAEVVQDEDHDEGLDNADDMCVNEISMAFDINAECEPMPDLDGPPPLVLEVDSNELEELTAEEQMVINNCRRLRKQTEFIEDLRPVDGNSKLEYSYRPMDQISQFWAGPSHWKFKRTRPRSTFSQTNGQVDTQPIRTQRAKKSAHLNANRRAKALDYGNVTENFFQQLDTTIRQRKANFQKKWDPRKLILPTKFELDPDLFFKYESAPSIKLSKRAGEPDSDEGGDLGIDMDADMHHDDDNDQELFNNEHFTDAVPANVSVIAAIAAEQAAEASMMNVSAGEIGLTQMNATCNNTVFEIGTEFEGAPSQVAKVIVPFAKRAKVIDMKNLKKSCNSLIQKQLLNAVPEETIPSHPKKKGEHYSKGFASFQQVYQKLPDLLTTKMSDSLSPSVAFYAVLHLANDLKLRLIPQEDLEDFQIRQVLD
The following text describes a protein:
Function:
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Subcellular Localization:
Cytoplasm, cytosol. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1, CASP4 or CASP5 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Sequence:
MAAEPEDNCISFVEMKFINNTLYFVAENDEDLESDYFGKLEPKLSIIRNLNDQVLFINQGHQAVFEDMPDSDCSDNAPQTVFIIYMYKDSLTRGLAVTISVQCKKMSTLSCKNKTLSFKEMSPPDNIDDEGNDIIFFQRSVPGHDDKIQFESSLYKGYFLACKKENDLFKLILKEKDECGDKSIMFTVQNKN
The following text describes a protein:
Function:
The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
Sequence:
MNILTLVRQVPDAEARVKVAGSGVDLEGATLVVDGMDEYGVEEALRLREGGAPVDTIIALAVGPQRNEDALRTALAMGVDRAIHVETDEKIDAVSLSKIVAQVAQAENAGLILVGGQEADWDSQALGAATAERLGWPQLTWTNELKVEGDSVTGRHDVDEGNESFRAPLPAVVTTQQGLNEPRYPTLPNIMKAKKKELRKDSLDTYGVQPRVRTVNAEIQTRARLNKMIDGKDPQAAAAELLNLLRNEAKVIA
The following text describes a protein:
Function:
Probably involved in the integration of pigments into the mature light-harvesting pigment-protein complexes. Light-harvesting chlorophyll (LHC) a/b-binding protein required to ensure a high rate of chlorophyll accumulation during deetiolation in continuous high light. Involved in seed germination. May fulfill a photoprotective functions. Prevents excess accumulation of free chlorophyll by inhibiting the entire chlorophyll biosynthesis pathway (e.g. 5-aminolevulinate synthesis and Mg-protoporphyrin IX chelatase activity), and hence prevent photooxidative stress.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with both photosystems I and II (By similarity). Coisolates equally with monomeric (mLhcb) and trimeric (tLhcb) populations of the major LHC from photosystem II (PSII) in response to 2 hours light stress.
Sequence:
MATASFNMQSVFAAPSGVLTTRNIRNTNQLFFKRIAPVGVRCMAQGDPIKEDPSVPSTSTSATPPQMPQSPPPPVSKPKVSTKFGDLLAFSGPAPERINGRLAMVGFVAAIAMELSKGENVFAQISDGGVGWFLGTTALLTLASMVPLFKGIRAEAKSKGFMTSDAELWNGRFAMLGLVALAFTEYVTGGTLV
The following text describes a protein:
Function:
Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAVDSTDQRRDFVVRIDGEDNGDSEKFWRESSINFWHNDKSSKPPGGEEDDGSFDFMRRSSEKSEEPDPPSKLINQFLNKQKASGDEISLDMEANMPELQKNTVPPLSSTAVSGSASPVTAPVTASYRNGTGDAIRRRQNRVTLSPSVKDGDSSEDEENRVDGSEVVKCTSNRSTMRTKTLMKMKTRSRLMDPPTPTYPDMVSGRTPRSGNLNPGFSGRNTKPGTPNQGGSKDLEEEEDPFSEEDLPEGLRKEKICVWVIIEWIFLILIIASLICSLVIPYLRGKTLWDLALWKWEVMVLVLICGRLVSSWIVKLFVYFVESNFLWRKKVLYFVYGIRKPVQNCLWLGLVLIAWHFLFDKKVEREMRSTVLKYVTKVLICLLVAVIIWLIKTLLVKVLASSFHMSTYFDRIQESLFTQYVIETLSGPPRIEIHIEEEKVANDVKTFEIVGRKLSPLGPKAVSSPPQVTVGSGRLQKSPSRVGKSPVLSRSGSKKEGGEEGIRIDHLQRMNTKNVSAWKMKKLMNVIKKGTLSTLDEQIQDTTTQEDDKATQIRSEFEAKLAARKIFQNVAEPGSRYIYMEDFMRFLSEDESERAMDLFEGASECHKISKSCLKNWVVNAFRERRALALTLNDTKTAVNRLHRIVDVLVSIVILIIWLLILGIATTKFLLVISSQLLLVVFVFGNSCKTIFEAVIFVFVMHPFDVGDRCEIDGVQMIVEEMNILTTVFLRFDNQKIVYPNSLLGTKPIANYYRSPDMQDAIEFFVHIATPPEKTTALRQRILSYVDNKKDHWHPSPMIVFRDMCGLNSVKIAMWPTHKMNHQNMGERYVRRGQLLEEIGRLCRELDIEYRLYPLNINVKSLPAATPITSDRIPPSWNQQRSV
The following text describes a protein:
Function:
Involved in DNA recombination.
Sequence:
MDWQAILIPGIPTLVTISVGALIYGRLKQQHRVDQTLHQQLLIIQDRLKQRDDQRNFIQSLIQQQQKEQIEQRQRFDEYQIKSLKLIQDSLIQNMQSIREQVSATLTAHAENLGNRVDKLTSETQERLKEISGQVDRKLTEGFEKTTETFTDVVKRLTIIDEAQKKITELSTNVVSLQEVLCDKRSRGAFGEVQLSNLIHNMLPESHYALQHTLTNNKRCDCILFLPEPTGNIVIDAKFPLESYQQIHNEKLSESERAQAEKQFRSDIRKHIRDIAEKYIVPGETAEGAVMFIPAEAVFSEIHAHYPDLIEIAHKSRVWLVSPTTMMAILTTARAVLKDAATRKQVHIIQKHLIMLSKDFDRFQDRMDKLAHHIDLAQEDVSKVHKSSQKITSRFNKIEKVELDFQDNQPTPDPVIPAPNRIGERE
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLMIQDGNKKVKIEVEEDCTVGELKCIIASEFSIEPDLIGITVLNKEINVFDDELVINVGIKNMTMIRISHLDQEEKKVKQGTSKGGYIVKIDRLKWVPIRRKMAADNSCLFHCLEYLFYNKSRNDPYHIRQEVSEIVQLYPQKFTTDYLGQPNSLYYQNILNPKIWGSNVEISIYSFLKECQIIVFDFENKVDITYGDKSLNRCCFIIFTGNHFDVLCLSHSLNSPENEDMVLFNNEDEEVKKKMKNYILSEYPKFHFTF
The following text describes a protein:
Function:
Inhibits cell growth by regulating the TOR signaling pathway upstream of the tsc1-tsc2 complex and downstream of akt1.
Subcellular Localization:
Cytoplasm.
Sequence:
MVYTPALVLGHGIPIVSEEDNIVELMRKFLCQITSSDNKYVRRGSIESSEFIKEINSSLDSETAPDCEERILHQDMTRQIVRCLSEAKESSLRCRILLLPRTLTANVALDVVRSSAGEPCGLRGAFIQVYLETQLGQQLQMLGTITPDPTVTPTFELSVVFKLDKDCWPLLKHIFVTDKVLKLRPQYRLVKKKLYSSASPVIHEFC
The following text describes a protein:
Function:
As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPKQQQHQLSAV
The following text describes a protein:
Function:
Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction.
Subcellular Localization:
Early endosome. Secreted.
Sequence:
MSSAHPATKQSTPSKVLILLSSVEPGTSPKHFVQVYSVCSTVFPTVHISTANGLPPIWSTKNTPHTTTHMDDATSKWIADKKNILSNPLSLEDLDPAIENYSGLVVPDADGFYFEPCCQKIHSFMEYFLKFKKPICMIGSGTAVLFSTEPKTGDMWIFRKFALTAPSNVSLIQSDQYLTNRSIEDFISDMYGRYSTGKSESLHVVIDDHIVTAQANTSTLIAIQTFILLCNR
The following text describes a protein:
Function:
Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Acts as a positive regulator of cell death. Required for both oxidative stress cell death response and hypersensitive cell death response mediated by immune response.
Sequence:
MYPPPPSSIYAPPMLVNCSGCRTPLQLPSGARSIRCALCQAVTHIADPRTAPPPQPSSAPSPPPQIHAPPGQLPHPHGRKRAVICGISYRFSRHELKGCINDAKCMRHLLINKFKFSPDSILMLTEEETDPYRIPTKQNMRMALYWLVQGCTAGDSLVFHYSGHGSRQRNYNGDEVDGYDETLCPLDFETQGMIVDDEINATIVRPLPHGVKLHSIIDACHSGTVLDLPFLCRMNRAGQYVWEDHRPRSGLWKGTAGGEAISISGCDDDQTSADTSALSKITSTGAMTFCFIQAIERSAQGTTYGSLLNSMRTTIRNTGNDGGGSGGVVTTVLSMLLTGGSAIGGLRQEPQLTACQTFDVYAKPFTL
The following text describes a protein:
Function:
Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation.
Sequence:
MARKSHMYNAIPAGFESDEENMENLMSNLKIKRLEDITTGAGIDGCNFDATLDAKAEEFFKLFREKWNMYSKKKSPHLRQEFGRALMGHQDPLLLALKIFANCPDSSNIKTKSLSHFVLDTVCKLHKDFPHLGEGCDPNTSMIAFNFVKTSGLLALNNAVIHAYSLRQIRDLLLPKLRELLDNGLYKEVTQWSISLQLTHEFDMLELAFPLIAIEKLPLAEEYLDHATQQRLPFVKFLDSLLHKEKSVLELCEHLLDRYKNLKISHNVLSYRPMAKIVARLAKKYGFDDAVTPNYKFTKTCSYLHYLYREYEKTRMNLASFREVVSVHAFNHELRTDFVKYLASAGAHSEAIYWYTEFNIDPKDCPLEIETQVSQNGAGKASGWESPGKERCPSSRCDMYLTMDLPDECLIIVNKADEFDRMLYHLQQECVIYLDSEWMQSVCGDNQLCVLQIATGHNVYLIDCLARESLRSEHWRLLGANIFNNVNIRKVGFSMVSDLSVLQRSLPLQLRLQMPHHYLDLRNLWLELKKQRFGVELPFGNVNRAGDALTDLSLACLGKKLNKSNQCSNWANRPLRREQILYAAIDARCLMLIYNTLIERVSFIQAVIEKSIASNNFLRRGAHVK
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4. Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).
Subcellular Localization:
Cytoplasm. Note=Transiently recruited to membranes to activate RAB12.
Domain:
Inactive DENND3 is found in a closed conformation, in which the linker region interacts with the DENN domain. Phosphorylation of Tyr-858 in the linker region intereferes with this interaction leading to an open conformation and enhances the GEF activity of the protein towards RAB12.
Sequence:
MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSLKMDNRDVAGKANRWFGMAQPKSGKMNMNILHQEELIAQKKREIEARMEQKARQSHVASPQPPHPGEVADAQNSCISNKFANDGSFLQQFLKLQKAQASTDSAPRAPPSSPAPSSLKRPLLLSKRTGLGLGSPMGPVKNYSHAKQLPVAHRPSVFQSPDDDDEEEDYEQWLEIKVSPPEGAETRRVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRKKVAEIRKEAQKPQAATQKVSPPEDEEAKNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYKQKLEEFRKAKAGSTGSLPAPVPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSIPGKPTATATVKRKRKSRWGPEEDKVELPPAELAQKDTDASPSPLSVQDLKGLGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWEKALQQHQHGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTQMGRGKHFIGDFLPPDELEKFMETFKALKEGREPDYSEYKEFKLTVENIGYQMLMKMGWKEGEGLGTEGQGIKNPVNKGATTIDGAGFGIDRPAELSKEDDEYEAFRKRMMLAYRFRPNPLNNPRRPYY
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
MEIKFFEYSDSLFNDQESRDLDRNTIFSSGISGSHFMGFAALSVYQKFRKQILSFDRIEILCGNGNNGGDGLALSFFLIQEGIKPTVYLKDGSLSEESKFYKDAFLNSGGIILPLEDFQFFSGNESLFLIDALLGTGFRFPLKSPFDLVISKIQKSKQNNSKNVFILSIDSVSGFQVDFPLPFEVDALAEIGIKKWKNRFLPKKIRKTFHRIGFPIDKNFYLQHKDGSFQSTILDPVNPNFQSTQIETPNLQVPKNKTSSENQKYILNPPEISFKPSQYEKLKVGTPVHNLESEIQKTEPQTSSFDPISNKTFNSIQTGKILWNPIPFKILKKSLKRNEDSHKYKNGSLVVVGGSKGMSGAALSSLLAFHELGGGISLLLTPSVKTIKEILKKDPSLMVDSIPDNSKILSHSFVHKTSVFLLGPGLKSDECPKFVLPEEKFCVLDAGAIQAFANVVLHDKVLMTPHTGELEILLNSKIKSIDQGISLAKEYTQNYNVNILWKRHSSFLIDVKGIVYLWEKPEPKLAVMGTGDLLAGILAFYFSRGFEVCNSVHLAFSLLTRAAQKSKGFPTASEIRKLLIQGGS