lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nucleoside transporter that functions as a pyrimidine nucleoside carrier in all organs. Has high affinity for adenosine and uridine when expressed in a heterologous system (yeast). Mediates proton-dependent adenosine or uridine transport in Xenopus oocytes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Plasma membrane.
Sequence:
MADRYENQPPEKLQGKYQAMVVCCILGIGSLVSWNSMLTIADYYYKVFPDYHPSRVLTLVYQPFALGTILILAYHESKINTRKRNLIGYILFTISTFLLIVLDLATKGRGGIGPYIGLCAVVASFGLADATVQGGMIGDLSLMCPELVQSFMGGLAVSGALTSALRLITKAAFEKTNDGPRKGAMMFLAISTCIELLCVFLYAYVFPKLPIVKYYRRKAASEGSKTVSADLAAAGIQNQSDLTDDDSKNQRLSNKELLIQNIDYAVNLFLIYVCTLSIFPGFLYENTGQHGLGDWYALVLVAMYNCWDLVGRYTPLVKWLKIENRKLITIAVLSRYLLIPAFYFTAKYGDQGWMIMLISVLGLTNGHLTVCIMTIAPKGYKGPEQNALGNLLVIFLLGGIFAGVALDWLWLIGKKNAF
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADYDGTITKLIPKHTAPKILCCHCGNAMVMRNDSTSGEAGKINLGVAKNSGAALCDDCIMAQIDITENIPKSAAENILTICKNCAKVSCPPGRAWIIAPQESRERLALCLKKIKGLTSSEVRLVDAQFLWTEPHSRRNKVKVTVRGESPQFPNITVQQDCVVEFTEGSGQCPDCAKSFTANKWTAQVQVRQKVDHKKTFFYLEQLILKSRMDDECISIEEAREGLNFLFASKHAAARFSEFVGSVVPCRIKQSEELVSTDTHTGHSTFKFTFSIDIVPICREDLIVLSKKQATQIGLYKSRVVLCYKIGSTIHLIDPNSLRTADVTQQQFFRDPFTPVVTSTSGGKSLTKFMVLDCEIILDPSVDVTESFSHVSAKHKLAEVTLARESDLGVNDQQYVIRTHIGAILQPGDTALGYFMGNTNVNHDEWESIPEEQRPDVVLVKKYYGEKKKSKKSRNWKLRRMATEYNEADDNQKNAHPSAPGGAEYEEFLNELEQDPELRGQIDMYAKDVENGTEEGDEDGDEDGDEDDGDYDDELDVKLDELKLEDMDEEHVVEEEEVKEE
The following text describes a protein:
Function:
Catalyzes the decarboxylation of S-adenosylmethionine, a key step in the biosynthetic pathway for spermidine and spermine. It is essential for normal growth, sporulation, and maintenance of ds-RNA virus.
Miscellaneous:
MISCELLANEOUS: Present with 7060 molecules/cell in log phase SD medium.
Sequence:
MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI
The following text describes a protein:
Function:
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The first transmembrane domain may act as a type I signal anchor. The PAL motif is required for normal active site conformation.
Sequence:
MKTHERAANLALAGLSLAPLVVKVEPNVNVILTACLAVYVGCYRSVKPTPPSETMSKEHAMRFPLVGSAMLLSLFLLFKFLSKDLVNAVLTAYFFILGIAALCATLLPSIKRFLPKEWNDNAIVWCAPFFHSLSVEFTKSQVVASIPGFFFCIWYAAKKHWLANNVLGISFCIQGIEMLSLGSFKTGAILLAGLFFYDIFWVFFTPVMVSVAKSFDAPIKLLFPTGDAARPFSMLGLGDIVIPGIFVALALRFDVSRGIKNRYFNSAFLGYTVGLTVTIIVMNWFQAAQPALLYIVPGVIGFVAVHCLWNGEVKPLLEYNESKAEEEDAVEEDTDSKQNKKEE
The following text describes a protein:
Function:
Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints. Required for daughter cell separation and chromosome stability. Involved in copper sensitivity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQPSTPKRSKGDWSTTQQRRSYSTPSALIFGSPEDTPASSSSFASSSSTGTTPNTSPQRPSQLPKSPSSPTPSRRGLRGKLASLTLGAAERVRSISGRIDDREPPVYAPPAQPLANPQESLMGWMVERNNGGTRPQQRHPPPRLDTSNYGVSAISNNGLLTPEQTPESSPIQPIHRAKGRTTSYYQTQPFKYTSSLREDPFIDRNRNRIKEVQELDFEEFNNSEDDFCLSETDVHSEFSSSADSTSSQCHKALRIPEILYNILSHVEADVQVPHEPPPQRRRPLSLRHAFLIYGDREKAHQAWERALKEEQTPTQQMFKGDGALHGCLLVNKFWFEVSRKLLYNKLHFCDSQKWRQFVHMSSDTGSPEDLITWSRSSHHRSLSRSTGQPNLHQLANGEAEMNDYFDTPTKLFVLHKISNAQQSEIDLLQHKIGGALEWLEFYTCAAIVPPLGLLAGGSLQKIVLPGCTKVDDAFLKLVAENCPRLQIADLRACEKVSNEGLVALAGKCPQLKLLNVGRTQMGHLISYRGISAIARKTQVNTLGAAGCFVCDKSMWELAWYRGHSLDRLSLNGCTLLTNDSIPRILPYTSNLAVLELRGCTQITDFKSIIKFKRYQERHKREPLIEGCEIFESRMREAEFQLEMDISREILRDCVQWIYAPDHDQESVRVKRKKVVPNFASTSRLSFIPHGSDAARKLAATSTRVESSSRHHSSRPSH
The following text describes a protein:
Function:
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein.
Sequence:
MVKISFQPAVAGIKGDKADKAAAAAAAPAPAAEILLTPAREERAPPQRYKKGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVLYEDSLSSQARTRMELEEDVKIYLEENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNRDLPPADVHHPGGDGGDRARQRQRGPGLLHLPPVQWEGHVPAAAPGYPEADQQARSEELQRHPPLREHLRGGDAHLRGGVRASPSRG
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGMRLSPEESTEANQHLQLPQQQLQTGREAASDDDRSVAADSWSIKSDYGSTLDDEQRHADAAEALSSAANFRPASDYSSDKDEPDAETSMLGLQSYWDAAYLDELANFREHGHVGEIWFGTDVMDTVISWTKSLCTDVSQGHIPNHVGEPKPQSVEHDEKYLSCWSVLDIGTGNGLLLQELSKQGFTDLTGTDYSEGAIDLARTLADRDGFSNIKFLVDDILETKLDRQFQLVMDKGTLDAIGLHPDGPIKRIMYWDSVSKLLAPGGILVITSCNHTKDELVQEVENFNQRNIAISQEPSATKDQETHRDHPPFRYLNHVRTYPTFMFGGSVGSRVATVAFLRN
The following text describes a protein:
Function:
A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products (By similarity). Mediates chloroplast nucleoid segregation during chloroplast division.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MRVLGFLSSHAGTGTAAAHTRWRWLAPLGIQAIRPASASAGGNAVSSATPQAPPCPIHANVGVGRASALGPGPSGFMAPSAGIVTAIRDGPNSNSRCSTVRTHATRSKSTGPSRATSSGPATAAPPRRRRRTSNDTQDGGLTSEQTPTNTAVAAVAATAAAAAGASASAAAPALPVALNPTWRTPPTAEAARRITQAASASAAYSGSSAAAAAAAVAAGPSSAASVARGGSAAAARSAAASALAANANTSSGAASAAAIAATASTAPGKLLLGGDLSRALAAAGSTTAPPLPLPSRAGLSAPKHTASAAAAAAAAASVLPASTPAAASQTPPTTVTSCGTGSGAPATPRAARSPTAAVSVSSADAAAAAAAAAAPASAAATAAAAVLPTRHIVAAVDPDLNGALALIYWDEDPNDPTTATASGPAAATTDAAAAAAAAAAAATGPAARLATLAAAAPPGSGAAAAADEAAAAALLWLPTPPRPPADASRWRVCVWDMPVSAAERQKRTASGQVARRRLLHVAGARAVLSAALAAALPPPGEARPVALYGYVEVPPILPGDGNIAAYTSLWSTGSWLGLLTGMGFTVGSTPVRRWKTDLGLYGAKGKDASLALARALFPGQQPILRHKKNHGRADALLIAAWALGACLPRGLGASLRRNGITLDQLLQQQPGTTVGLVWGPPRPPAPTDAYGNLLTPEQDMWDEIEAAETKVERKAQARSSTARRRKTAGTQEEPEAQAEEEQAEAGTGVVAAAAGAAAPKRRRAKKAAVESGSEAAVAEVAAGPQEEGSEGEVAGQGGRACRSKSRSKSSGKSSSKAEAGGAGSGRRRAASVGSSSVGSSSVGSSSGGGGGGGGGVKAPGASRRRGGAKAGSDGGVSGSESE
The following text describes a protein:
Function:
Member of the two-component regulatory system SenX3/RegX3 involved in stress response. Autophosphorylates, and then transfers the phosphate group to RegX3 (By similarity). The system is involved in phosphate starvation response. Plays a role in modulating expression of aerobic response and in the regulation of response to hypoxia. Involved in virulence. SenX3 is a key regulator of mycobacterial replication in response to oxygen, nitric oxide (NO) and carbon monoxide (CO), and acts as an O(2) sensor that plays an important role in the reactivation of growth in response to the restoration of aerobic conditions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNRSQREEELSR
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRVGKLCRLALRFWMGLILVLGFSSHYYNPTRRRLVYSRILQTYDWLLMVINLGAFYLYYRYAMTYFLEGMFRRQGFVNQVSTCNVFQQLLMAVTGTWLHFLFERHVCQTYNELSRILKHDLKLKEHSRFYCLAFLAKVYNFFHNFNFALSAIMHWGLRPFNVWDLLANLYFVYNSLARDAILVAYVLLLLNLSEALRLNGQQEHDTYSDLMKQLRRRERLLRIGRRVHRMFAWLVAIALIYLVFFNTATIYLGYTMFIQKHDALGLRGRGLKMLLTVVSFLVILWDVVLLQVICEKLLAEENKICDCPEDVASSRTTYRQWEMSALRRAITRSSPENNVLGMFRMDMRCAFALISCSLSYGIIIIQIGYIPG
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Sequence:
MMVKPCWHCAVSPSLAVIRAAGAPFYRRCYSASMAISTQPTSPELHKKVKPFSEIPGNWKNGLVNLYNFWKLDGFKNIHGIMLDNFNTFGPIYRSKNSIYRVLKILLEPELCIVIIKRQDDSHARSQSWFSFTKICKIRNLETIGVRFGAHLYGSASLVNQKDYSCTSPQNTLPIIPDFHTVLPKSTHLITLTEGWEGSESTQSEQDYQHPTVSSVLYGERLGLLHDYIDPEAQHFIDCISRMFKTTSPMLYIPPGLLRRLGSQVWKEHVEAWDGIFGQADRCIQNIYRQLRLAPTNDRKYPGVLASLLMLDKLSIEDIKASVTELMAGGVDTTSITLLWTLYELARHPGLQEELRAEIQAARASSDGDITQVLKAVPLVKGALKETLRLHPVAVSLQRYITKDIVIQNYHIPSGTLVQLGLYAMGRSPHVFPRPEQYQPSRWLRGEHSYFRSLGFGFGPRQCLGRRIAETEMQLFLIHMLENFKIEKQRQVDIRSTFELILLPEKPIVLTLRPLQQRK
The following text describes a protein:
Function:
ABC transporter controlling the release of volatile organic compounds (VOCs), including floral volatile benzenoids and phenylpropanoids (FVBP), in flowers of fragrant cultivars (e.g. cv. Mitchell and cv. V26). This scent, mostly produced in the evening and night by the petals, attracts the pollinators (e.g. the night-active hawkmoth pollinator Manduca sexta).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTNQLPNKVELAEVVPQNGGVFLTWEDLWVTASSVKDGSKAILKGLTGYAMPGELLAIMGPSGSGKSTLLDTIAGRLGSSTRQSGDILINGRRQTLAYGSSAYVTQDDTLLATLTIKEAVYYSAELQLPNSMSKSEKKEIADVTLKGMGLQDAMETRIGGWSGKGISGGQKRRVSICLEILTRPKLLFLDEPTSGLDSAASYYVMKAIASQCQGRTIIASIHQPSVDVFSLFHSLCLLSSGRTVYFGPASAANEFFALSGFPCPTLQNPSDHFLKTINSDFDQDIEEGSTRRKSTEEVIDILIKSYKASDKYNAVQSQVAEICQQEGEMLDKRSHASFITQSLVLTRRSFINMSRDLGYYWLRLAVYVVIAVGLGSLYYDVGFSAASVQARGSMLMFVASFITFMAIGGFPSFVEDMKVFQREKLNGHYGSGSFVIANTLSAMPYLLLVSLIPGAIAYFMTGLQNGFEHFIYFALVLFTCMMIVESLMMIVASMVPNFLMGLIAGAGIQALMLLSGGFFRLPNDLPKPFWKYPLHYVAFHKYAYEGMFKNEFEGLKIHDVNGEDILRNTWQMNMDYSKWIDLVILLGMLVLYRVLFLLVVKAGEIVKPAIRAFMSHSPNQINSAERPLDVFDS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGKQRGERSKSRPSSSSLAASLVSGGNAPPAGFGFGGFVGSARVAEATKGADEEISADIDGEIASHLRRLSKRDSTTKLKALAALGPMFHERPPSELVAVLPSWVFIYRRLAADSSRQVREQAHLAMKELASRVGRSLAPHLRVLMGPWWVSQFDPSREVAEAARASFLAAFPAQKKQVEALAFCQGEMFEYLDETLGVTPQTVDKSVAPEEAADWVERQLSAGLLAMATLLQVLGGQAGGGGDVREETTRGGKEEANGKQQTTSEEEAHENESGQKDADASKGGGIDPGEGSSGAAKVVELAGGVAARHRFFAPCLKHASPVVRGAAYQTLRALCESARAQIRENLSAVAPLILGSLTEREPAVHRAMWDMLLSFVRFFSGGWEFVNVRKAVLPGLWGLLRHACYGSAEVSYPCLLVLVSLLPHGVVGTGPEFWGELFGALWGGREACVAEVEWQALLRAWRECLVYVLTNAEKYAEPGREGTLAFRHEIVRTVLLDTAWDEYMQSGGGSRAGAATPTKSAEVSRDQDADRVSSHARAGPSGQAAAGGVADERNGREATAGSMGRGSLRMLDLAEAMGEAVIQMEKIDDALSEFWADLTKRILATLSESGGGDPNAVVKRVGDFYMVVSRLAKRPPVLGKKGPALAMGQRKSNALDAGVKPLVAGVWELAVGSSDAVPLVRLLTRLVTLYGTESLGGIADKGETAKSQFEAVRFLVTTRLIPWCLGGRGEERSTVEGGTRLEFLLAILKDERLRAEWEGVLGRLTRWAVKAGGSEEDTVAKHLEDVETLGAVLGKLREQGAARRLNLESAGVDAAALVVGSSSSLEEAPCQEFLKQAMGAGGGRVPFVSGAALRGVLERLLQRMDEGRQGGKGADLALAAVDIGGAYALSKKVPEEVEEVRGKILATLFSLSWLGGKAAGGVEIGEGATDGATESGIETQVTQTGGKETGSLEGSVERLAAAARLLAGALTQDVVVQLGAEQRAAVQHLLVEEIRRQVAEGEPATCVQVAERAAEVVQRLAVGREERGAVIDLSVAPMGSWPRWSRAMLPAGGKNRRGSEEGVKVERAFAAFVGALVQRIGLEEVFLAGTETDSEKGEEGGEKNRAWLAIELVVAHEAEGAENPGAVMRFLVECGRSATDREFALLHHVIDGLVKAAVADVSGEQDTVSAENALRALCRLLGELVGGAAWGGDEVLPIVMPHLREQRPGDSEGAVNKTVGIWLKQALEALPLTAPEEGPKGEAALEKVLLAVSCFPLHAEGGEEAVKNAARAAPPEKQADTLLELLRRQFHSREAMAAVAREAAAKRLGAVDPGDPDDIDGQDASGDEWADRVEAALAQLMMAAIAYGWAHFGEVEWGDVLGRVEKWLEKMVSSQEEHAETLSEAIAEAVQTEGETSVRQTAVFEEVRDCLHSADDDLSGLPLLSVKTLELLLALPLPGSSAKAVDIGAVGGIDGDEWLRMRHVALVGALRMVCIAGLEEAAAREAGGDRTAELVVGAREKQGAFWGSVARVSSYATVGAITEAATSMDTWAEVGVGRGAVPSLQALLFSPRPSPPLQRAAHSLLSRTPLLDVAVSTAKDEDASAEDEALVSAEHPAVVAGIRPEMAAILETRAGDLLLAAPLAPLRARYLLAWSLLLARLRSLPATAPAYEKLVQYVQETGAALNLLEVLFQYIPLDLTPPKAKAAPKRAASLETPASEWFPVTKASLPGMAAALYMDVLRVLPACARLWFMDLRERSVAAAVEAYTSGACSSALLEAEFRAVQESVGTQDNLSIRANRAAREVIAAYSMDESSLEMVIRLPAAYPLRPVEVECTKRIGVSESRLRKWLLSISAFLRHQNGAVSAAVLLWKQNVEREFEGVEECPICYSVIHTTNHALPRLPCKTCKHKFHAACLYKWFASSHKSTCPLCQTPF
The following text describes a protein:
Function:
Seems to have no detectable effect on transcription elongation in vitro.
Subcellular Localization:
Nucleus.
Sequence:
MLRSTGFFRAIDCPYWSGAPGGPCRRPYCHFRHRGARGSGAPGDGGEAPPAAGLGYDPYNPELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTREHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSSCRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVAKQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHLVIWKVREDAKTKR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Targets sde2 for degradation (Probable).
Domain:
The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
Sequence:
MQLHDPPAPLSQPSASRLQKYLLESAEKHAYDSNEESKTHLLQEVFLSLLNYNEDNWKYFLKEKPGAITSDFRLSRLQHSEPECAQELQDKRSGSKVCGHVFRAGEVIYRCKNCGLDNTCVLCAPCFHATNHEGHETHVSISTSYSGICDCGDPEAWNVDLNCKIHNVPDDEEQKKPEEVIPLELQHSIRTTIHILLDFILDVFSCSPVNLKAQSTVGSILADEEASRLSSAKYGVADRPCNVFRVMLWNDEVHTFDAVVGSVLEALDSSNTAFGLEVAQRVDSIGRFAVATSASVHEAIRIANAISKENLAVNVRTARDFFREDICGILLEWFDDLLESHVCYFADYLQIIVCDEILKNWSPGLEKPAKPEVNFNNLPLEIVNDDDSEDDIYAAEELLDVIANLQDETGVTRIANLGGDEDFEADMTDPTIAGFDHPLDDDNDVNDLLDFETEREDIDDLTDEVMETEENEAAEADYPGVNRNTRQDDVQDISMETESQNETDESQNTENVDYNPQTHTPVPIPTTATQDVVTIRPEFNSQLLNNLRQIINARRRPRPAAVCQVSLREDYWKSPHPIPPSSYSFVESPSSILRLDYFLLFDLKFWKRLRGLLSKLYVVPFNRNLLFKRLMGIRFVIHYRSLATAFLFADREPDHSVMFLSVQFFTTPSLAEAVVKDYDFLTNLNATTLSLLTQSNRPSTLFSSDIEYTPTIQLNRQVLKTRRTYNLFSDLGYLLQHPQVKKLVVDDTRYVHQYIDLLRVFQGVIPQQRAILSHVQWDFPHGKNILFVMQRVAMLSNTVSSCFTQAPYERLFYAIKCIITSITHPKLDIAESLEPLSCIPSSSLTNFTQPLVPFSVSRDPISFYHPLHWMLSNLFSYCRVDASSHWDKDTLLALLDHPLRVCVLLAQIDCNLWIRNGRSILLTDAFYRQLNNIEVSYDKDILAIQTILMFVDPNLVLNAVVQRFEFTDWLYNLTYNEHPNYDTERIPAMLCKMLELLIALITEREQILHVDIQDIIRTRLAQQLCFGPLAYSALLSTISSNLVESLSFDKIREEVTSYKAPDGLHDFGVYSLKDEYYDLVDPYYFHYNKNEREESDTILKKRLAKKNNVSAESIIIEPKIRFLEKDGHDIFFAAVNASTFSLIIFRAIEYALVQAESFGSSDIGNTILGDALQLCLISMKIHEFSKSNDFCSRSCAERYPTDSSIMREFGGSAYCLAELCFAILKSPKYKDVHVKVNAVLAGLQKNDPSAYSNMLEATHFELSTTSSTSDSNEIEKTQEKKRLALEKQKKIMQQFRDQQASFLAQNTDFDIGEDQTEDEVTTEEPEEEVKYHEHIRGNCLLCQEECNDQAPYGVIGIIQGSSLLRKTDVHSEIILDEIYSVPPNLDRESHSRPFGKKYDTVVFNRSKDRLLSAYPPGNNIRGVFVSGCGHLMHLGCFKNYYVARSMYRNDVTAGLSEYYYKYSTAKFFMCPLCRSLSNVLLPMPQIPKMCLNIDTLNFPRSMNGWLEEIGTMSSSSFEYQLVRSSLSDTKDTFRSCFLRPWINSKIISAMLARLKIADGALIDQSNNRDVSDLYDRYCETTKLAMKLVKGSTFTNVSPHDLLNSLAYTVSSLEVSQRCSPKQSGATRSVWFNELGPLTLSFLPTLSDTVLKCVCDQIIKSDQQALLLMESQKLLVCKIFYRHSQLKSMLRNGRMSDHDQIQPFLLSNTFDDFVKISSLMLIFGKQDNILYYVKLFYLSEICKTIISMIKVVADSSVVPDLTINYSQQSKSQFYILCKNVLLWCGSSNNIEILDDESNLLRLMSLVEKYSLPFLRRVALVLYCMFDISLEFNEFSNNEDDSELERLSKLIKVPPLQELYSQMSSDENNQILELIAGWCEHLAQNTWGDSTISLEYPGIYELVKLPHRLENLIDSMQESVCCMCHKTPILPAICMLCGSVICFNARQNTVSSRRLTGECNKHAATCTGSVGIFFITKACGILLLDSISNTGTIMPTPYLDIHGETDLQLRRGCPQFLNQKRYDFVVREQWLRQTVLQKMARHMDMTEMQNWRMA
The following text describes a protein:
Function:
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Membrane, clathrin-coated pit. Early endosome. Cytoplasmic vesicle. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface.
Sequence:
DAEFRHESGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
The following text describes a protein:
Function:
Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.
Sequence:
MEIPSKQIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFNENLAYEIINNTKIILPILEGALYDHILQLDPTYQRDIEKVHVRIVGIPRVIELRKIRSTDIGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPEDEEMPEVLEMPTICPKCGKPGQFRLIPEKTKLIDWQKAVIQERPEEVPSGQLPRQLEIILEDDLVDSARPGDRVKVTGILDIKQDSPVKRGSRAVFDIYMKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEALALALFGGVPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRVAPRAVYTTGKGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGIAVIDEIDKMRDEDRVAIHEAMEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFILKDQPGEQDRELANYILDVHSGKSTKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFFVEMRKKSSETPDSPILITPRQLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLESVGVDMESGKIDIDTIMTGKPKSAREKMMKIIEIIDSLAVSSECAKVKDILKEAQQVGIEKSNIEKLLTDMRKSGIIYEAKPECYKKV
The following text describes a protein:
Function:
Acts as a glutaminyl-peptide cyclotransferase. Responsible for the biosynthesis of pyroglutamyl peptides (By similarity). Might be more efficient in the conversion of tri and tetrapeptides in vitro. Might have a relative preference for substrates containing hydrophobic amino acids in vitro.
Subcellular Localization:
Secreted.
Sequence:
MAIGSVVFAAAGLLLLLLPPSHQQATAGNIGSQWRDDEVHFNRTLDSILVPRVVGSRGHQQVREYLVQSLNGLGFQTEVDEFKQRVPVFGELTFANVVGTINPQAQNFLALACHYDSKYFPNDPGFVGATDSAVPCAILLNTAKTLGAYLQKEFRNRSDVGLMLIFFDGEEAFKEWTDADSVYGSKHLAAKLASKRSGSQAQLAPRNIDRIEVLVLLDLIGARNPKFSSFYENTDGLHSSLVQIEKSLRTAGQLEGNNNMFLSRVSGGLVDDDHRPFLDENVPVLHLVATPFPDVWHTPRDNAANLHWPSIRNFNRVFRNFVYQYLKRHTSPVNLRFYRT
The following text describes a protein:
Function:
Catalyzes the conversion of 2-formylglutarate to (S)-2-hydroxymethylglutarate. Has very low activity with (S)-3-hydroxyisobutyrate.
Sequence:
MEKSIKIGFIGLGAMGKPMAINLLKEGVTVYAFDLMEANVAAVVAQGAQACENNQKVAAASDIIFTSLPNAGIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEKGIDYVDAPVSGGTKGAEAGTLTIMVGASEAVFEKIQPVLSVIGKDIYHVGDTGAGDAVKIVNNLLLGCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYAMEAKMEKFIMSGDFAGGFAMDLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLGREDMSAVIKVWEQMTGVSVSGGQ
The following text describes a protein:
Function:
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Sequence:
MLPLVALVGRPNVGKSTIFNALTRTRDALVHDQPGVTRDRNYGVCRLDEQQPFIVVDTGGIAGDEEGLAGATARQARAAAGEADLVLFVVDGREGASSLDDEILAWLRKLARPTVLVINKIDGTDEESVRSEFSRYGFSDVVALSAAHRQGIDDLLEEVGARLPEEGAGELLDNDPARVRIAFVGRPNVGKSTLVNRLLGEERMIASEVPGTTRDSIAVDLERDGRQYRLIDTAGLRRRGKVEEAVEKFSAFKTLQAIEQCQVAVLMLDATEGVTDQDATILGAILDAGRALVVAINKWDGQSDYQRAQAEDLLSRKLGFVNWAEAVRISALHGSGMRELFQAIHRAHASATHEFSTSEVNQALEIAYETNPPPSIRGHVSKLRYVHPGGANPPTFIVHGTRLKVLPESYKRYLENFFRKRFKLVGTPVRFIFREGANPYEGKKNPLSDRQIARKRRLMRHVKGK
The following text describes a protein:
Function:
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
Subcellular Localization:
Periplasm.
Sequence:
MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIPNHWHGDCIGGLGYLQRKGVQSYANQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGGCMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVNQYIESTSKP