lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSRFGGRLREYPQLSIDRFDYDNLRARAYFLSHCHKDHMKGLRAPALRRRLQSSLKVKLYCSPVTKELLLTNSKYAFWENHIVALEVETPTQISLVDETTGEKEDIEVTLLPAGHCPGSVMFLFQGENGTVLYTGDFRLAKGEAARMELLHSGTSVKDIQSVYLDTTFCDPRFYHIPSREECLSGILELVRSWTTLSRYHVVWLNCKAAYGYEYLFINLSEELGIKVHVNKLDMFKNMPEILYHITTDRYTQIHACRHPKDDDYVRGNRLPCGITCQNGTPLHVISIKPSTMWFGERIKKTNVIVRTGESTYRACFSFHSSYSEIMDFLSYIRPVNVYPNVLPVGGSEDKVMEILQPLCRSYRRNTEPRYKPLGTLKRACKRNLSDTDEDELFDTELSARPKIAKYQGEESKPSQTAQPENAERNINESTESYRANTAYTSLKVDFVDCEESNDDDDDDDDDDKEDDSEKNTAQVLSHEPDANSIASCNGIPSNQQESNADIPSWDMFFKCNKVDESSENEDNFPSSADAGGSQSLFSDSDGVSDSTHISSQNSSQSTHISEQGSQGWDSQMDTVLITSQERNAADFSCFSRGGSRTALLSHDTPRDSQADDSRWKLLGQNPSCASDVICDLKSEDCEKDAEAGTAPTQDLLVEISDSSRTPDLELKRDSQSSSDFEIPLTPDAEIPQRDKLHYLYKKLAAGESIMRKNSPEKR
The following text describes a protein:
Function:
Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDGQVTVKRHGDTHFANIGYGYYTFGVSVGYILLLLLLRKRRGTAVPRSRHKLFQMMIDGSPALHLPILLLFLEIAFLGHYSVIDHASVYIKRLGRLSYVLLFLNIFLTLRPNYILSDYTYVQLLPMHMWLSRAISTFGVFHGLAFVIKWQLDNEVSLASKLFNLWNLLGFIVWILLIILLITSTGVIRRRSYKSFYMVHQINAFAISFIVPVHARPGVALPYTITIAVLLGLHALARVSFCMSSAVVHKLSNYQKGSKLVRIKLPRNVMPEHFTPGSHIRVSPYRRSNPLYWLVPSHPFTIASLPDDDHVDLILREHGHFEFEVGPRYSIVHNYEGITALQLGLVNRVTIVVGGTGISLGLPLFRYFKENTDIGYLKMIWTVKSHADLHVLDDFEGIDIFVTQNTTTTPIPGASESWDEIPLEEFELNSMDDLEAEEEHLGESGALLPTTKRKKDPGAINIGRRLDWNVELASFVRSEGSSDQLLIVCGPESLVKDGVQFATDHNIVFYKEVYSF
The following text describes a protein:
Function:
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MHIFKNLTEPTAVTHSLSCNFTGERNLVLVKGSQLLQIFRYKDDIPTKDEAPRLELITEYYLDGTVTGVTRIKTIDNYDLDSLYISVKHAKAVIVAWNASSFTIDTKSLHYYEKGLVESNFFEPECSSVAVSDEANSFYTCLLFQNDRMAFLPIIEKGLDDDEMPESGQVFDPSFIVKASRLDKRIENVMDICFLHEYRETTMGILFQPKRAWVGMKNILKDTVSYAIVSVDVHQKNSTVIGTLNGLPVDAQKVIPLPAPLGGSLIICANTILYIDSSASYTGVMVNNTHRQNSDLIVSRDQSTLDLRLEGAEVCFIQELGNTALLVTEDGQFFSLLFNKDGRRVASLELRPIEPDNFILSQPSSVAAGPDGTIFLGSRAGDSLLVKWYHGEPESQPEETLDDGNESDDDLYGGDTAQTEDTTNRPLKLRLADRMLGMGPMQSLALGKNRGSQGVEFVTTTGVGANSALAILTSALMPYKRKSLYKDMPGGQFWSVPVRFEEEGEVAKSRTYVVSSDSENSYLYYVDAAGVIEDVSLSTKKKKTKKHFVSNVTTIFSSSMLDSALLQVCLETVNIYDAKIGQPHKYSLPQGTTAVEARVLGNYVLVLLSDGQVKILEAVSINKRPFLKAAQVSIEPASESKAIGIYATDSSLTFGAPSKKRTRQGSPAQDSRPVVVVCYADGSLLLQGLNSDDRLILDASDLSGFIKEKDGQLYDAPLELVDIALSPLGDDHILRDYLVLLTPQQLVVYEPYHYNDKLRFRKIFLERTPTINSDRRLTQVPLINGKHTLGVTGETAYILVKTLHTSPRLIEFGETKGAVAFTSWDGKFAYLTQAGEVAECRFDPSFSLETNWPVKHVQLCGETISKVTYHETMDVYVIATHKTVPHVVRDEDDEVIESLTPDIMPATTYQGAIRIVNPYSWTVIDSYEFEMPAEAALCCESVKLSISDRKSQKREVVAVGTSILRGEDLAARGALYLFDVIEIVPEKERPETNRRLKKLVQDRVRGAFTAVCEVSGRLLAVQGQKLLVQALQDDLTLVPVAFLDMQTYVAVAKSLNSMLLLGDATRSVQFVGFSMDPYQMIPFARDLQRVLVTTCDFAIEGENLTFVVADLQKRLHILEYDPDDPQSYSGARLLRRSVFYSGKVIDSSAMVPINEDRFMVIGVCSDGSVTDVVPCPEDAYRRLYAIQTQITDKEAHVCGLHPRAYRYDPILPGTGNSPHRPILDGHTLIRFANLPRNKQNVYANRLGQRYQQLIWKDLELISDLFKKCI
The following text describes a protein:
Function:
Is important for morphogenesis of limb and kidney and may be involved in determining dorsoventral neural tube polarity and motor neuron induction. It may also have a function in differentiated cells or be involved in maintaining specific differentiated states.
Subcellular Localization:
Nucleus.
Sequence:
MEGGNAGCSRQLPERAGPAESEPDVFTTFAVRTLLGLTTKLESVTPKEEEAVLKAFQPLHIDVNTQANNRYERNDNDGVDDSENQHCESCTSDQADPMSGSRAEPELEPEPAGQNEILLPHLRSVQTSLSESDNDAILVQGTLVHTTSDTESDGESKDPDADETGTSKCGLNNAALSAVALDGNNQSKEESDSEGYGHSDDTVGRDDTELHPPISQWLPRKLDSILEHDSSGKDRTLMDEQFSCLLATGECSPELSGEDQRPSADNVSFHKAALTERSFQLPAFFSGLRVRKKGLNTEDGETITEIKPRENDLALLKLRQPVKKSNITSGLTTKKKSSEPKASPTFLEQLSHLLNIDVSKNDERTQDSGAGFGETEDSDEGPENKASGQTEPLFPSEEIKSSPAESALDVFKALFTRPPKKETTADPSELEAIKRKMRNEKESLKAVFERSKSKPGDGPSDKSPDLSPSEQDDKTPGRLQTVWPPPKANHEEVKVGLKYTEAEYQAAILHLKREHKEEIETLKSQFELRVFHIRGEHAVSTAQLEETIAHLKNELDNKLNRRNEEARDIGVSTEDDNLPKTYRNVCIQTDRETFIKPSEEENRAVKNNQIVPKKLNISSLTHSISTQGENKDSYDVPSSESVLSCQPKQMLPPSPPPPPPPPPPPPPPPPPFSDSSLPGLVPPPPPLPTGPTSVTPHFAFGPPLPPQLSEGCRDFQAPAPPAPPPLPGLGPPVPPPLPGSGLPPPPPPPGPGLFFNSTLSSSQGPRKPAIEPSRPMKPLYWTRIQLQGSRKTAIPTLWESLEEPDILDTTEFEYLFSKDTTQEKRKPLSETYEKKTKAKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAILCVDDSVVDLETLEALYENRAQKDELEKIEQYYQTSKEEELKLLDKPEQFLYELSQIPNFTERAQCIIFQSVFSEGITSVHRKVDIITRVSKALLNMTSVKEILGLILAFGNYMNGGNRTRGQADGFGLEILPKLKDVKSRDNRINLVDYVVIYYLRHCDKEAGTDKSIFPLPEPQDFFQASQVKFEDLIKDLRKLKRDLEASEKQMKLVCRESSEEHLQPFKEKLEEFFQKAKEERKKEESSLENAQKCFEETVGYFGIKPKPGEKEITPNYVFTVWYEFCSDFKTIWKRESKSISKERIKVAQQSVSKLTAEKKVETKKINPTASLKERLRQKEANVNAN
The following text describes a protein:
Function:
Putative transcription factor that functions in pseudohyphal growth.
Miscellaneous:
MISCELLANEOUS: Present with 1420 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MYHVPEMRLHYPLVNTQSNAAITPTRSYDNTLPSFNELSHQSTINLPFVQRETPNAYANVAQLATSPTQAKSGYYCRYYAVPFPTYPQQPQSPYQQAVLPYATIPNSNFQPSSFPVMAVMPPEVQFDGSFLNTLHPHTELPPIIQNTNDTSVARPNNLKSIAAASPTVTATTRTPGVSSTSVLKPRVITTMWEDENTICYQVEANGISVVRRADNNMINGTKLLNVTKMTRGRRDGILRSEKVREVVKIGSMHLKGVWIPFERAYILAQREQILDHLYPLFVKDIESIVDARKPSNKASLTPKSSPAPIKQEPSDNKHEIATEIKPKSIDALSNGASTQGAGELPHLKINHIDTEAQTSRAKNELS
The following text describes a protein:
Function:
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTFTINNTNSTVFDSTNNENMTISEPVQPVSKGPKGITFSGETFIVPETHDMVKTLFDPTVKKSNFELIILSCLFSNLLVFLISNNQIRIYIFIALYIFWRLSYNFGIGWLLQNQSNHNLLVSWSQKYHLFDPENKGALAQSIQNEIKSQRGENYDIKSMPVEFNTWLIFRKFVDLILMSDFITFCCVVFCSAIKDDYQFINNQSSWLVYSRIVLGSGLILFNLWVKVNAHNTIKDYAWYWGDFFFRQINNEELIFDGVFEMVPHPMYSVGYVGYYGFALIAKSYVVLAIAIFGHFLQMIFLHYIENPHIDKIYGPSKNEINLIKILKLKDLKNFDNLKPLVGLTNFNWMRASDIVNLVLSLTYGIIIPLFANSIKSLFILTVGMKLFESISINLSLTLQSYFKIVTKWSLSNDIPVEKSFSNWAVLYNSLINLTYSSLFGMNLGYFLQKSGSDSPSSGLLFSDWFYLRVFLGLLLIYTQFWINFSIIDSIGYFGWFYGDFFIPKSQSSIKNITTAGVYRYLNNPEQIFGVCGVMGIFLIYPTVENFVCVGLWVVNNFIRINFIEKSHMVKLYGEQEVNRDSGVTKTVKKHLLPEVIQRRMSNDEAYTRINGTTHGRRRRSSNLHRNSVADSLDNFIRDLRNSSTKLSQQKLIELSQNLSFANSDYKLTIDGLKMQSTESDELKYTTIGTPVTVSWTSPTENHSVRDWIGLYKIVQTSYSRNKTILSSAGRWTWCKEPKGSFIFDKEKLFWEEGVYEFRYHLDGKHDVAYISEPFEIKSIELKVPEFKEDAIKFAENLKLEIFDKVIKLTDISEAISPIANQSDNVIEVYKLISSMISKSTKINITYKIFLNQGDDDLLSIKDVAIKLINIKHVLEELSYNITDKKDV
The following text describes a protein:
Function:
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
Subcellular Localization:
Cytoplasm, perinuclear region. Golgi apparatus. Nucleus.
Sequence:
MSNKEGSGGFRKRKHDNFPHNQRREGKDVNSSSPVMLAFKSFQQELDARHDKYERLVKLSRDITVESKRTIFLLHRITSSQYLNYSAPDMEEILTESEIKLDGVRQKILQVAQELSGEDMHQFHRAITTGLQEYVEAVSFQHFIKTRSLISMDEINKQLIFTTEDNGKENKTSCSDAQDKQFGTWRLKITPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRHVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVFSVKTEMIDQEEGIS
The following text describes a protein:
Function:
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate (By similarity). Chitosan is required to anchor melanin to the cell wall, for maintenance of cell wall integrity, and for proper cytokinesis (By similarity). Chitosan offers an advantage during infection as it is less readily detected than chitin by host immunosurveillance mechanisms (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MYGHLSLSTLSLLAVVAAAPFPESWLQPRDSDVSQLFRRGAPDPKASDYLSYYPSPGSTPNVSTIPQAWLDKLATVQLPNVSVATANDGRPTYPNNENDGDSEICSFTDQCYVEDDLYSPPGEKVWALSFDDGPTDVSPALYDYLAQNNISSSATHFMIGGNIITSPQSVLIAIEAGGHLAVHTWSHPYMTTLTNEQVVAELGWTMQALSDLNGGRIPMYWRPPYGDVDNRVRAIAKGVFGLVTVLWDSDTNDWAISDQPDQYSVASVEAYFDTLVTGNRTQGLLLLEHELDNNTVEVFETEYPKAVANGWSVKNVADAFSMKWYLNSGKGNDDVVTTMSVAGTLTTAKPTHTSTSVASATATSSASVTDSAGVSIASAASSQESSSWPIANRPSLFVIACGLALAAIMV
The following text describes a protein:
Function:
A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export. When overexpressed increases secretion of FMN and FAD but not riboflavin; intracellular concentrations of FMN and riboflavin rise, possibly to compensate for increased secretion. Increased overexpression causes slight cell elongation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLRHILTAKNLLSNPIFKFPNCLPFLSTVCCICRQFVGENLCSFADSPSLFEMWFHFLQLRSALNISSALRQVVHGTRWHAKRKSYKVLFWREITPLAVPIFMENACVLLMGVLSTFLVSWLGKDAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARVATRQSLVIMTLFAVLLATLIHHFGEQIIDFVAGDATTEVKALALTYLELTVLSYPAAAITLIGSGALRGAGNTKIPLLINGSLNILNIIISGILIYGLFSWPGLGFVGAGLGLTISRYIGAVAILWVLAIGFNPALRISLKSYFKPLNFSIIWEVMGIGIPASVESVLFTSGRLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGSALGSASTIITGRRLGVGQIAQAEIQLRHVFWLSTLGLTAIAWLTAPFAGVMASFYTQDPQVKHVVVILIWLNALFMPIWSASWVLPAGFKGARDARYAMWVSMLSMWGCRVVVGYVLGIMLGWGVVGVWMGMFADWAVRAVLFYWRMVTGRWLWKYPRPEPQKCEKKPVVSE
The following text describes a protein:
Function:
Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDSTALKVALGCIAIRLAVNSLFPSLQQQLDQSVEFSTPVTSFRSLQEGIYLLRNNIQVYNHGVVHHPPILIFFLSLFNSDRLISLIYALIDGLIAYQLTEVTKAFKNLKLKVWLPGLLYAVNPLTLLSCISRSSIIFTNFAISSSLYCILAEGNVLLSSVMISISGYLSVYPILLLIPLLGMLKSWRQRILSAIVSILSLLILLLFSYSILGSQSWSFLTQVYGSIITFEKVFPNLGLWWYFFIEMFDTFIPFFKAVFNIFIAVFITPFTLRYHKQPFYAFILCIGWIVLTKPYPSLGDAGFFFSFLPFFTPLFGYLRYPIISALLFLHAIVLAPIFYHLWVVLGSGNSNFFYAISLVYALAIASILVDLNWAMLRIEYDNGIPNFKLKVTQI
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MVRLIHLIGAIILLFSYAYCGLSRLNEHDIEESYSHKRVKRQFERLGTKWSYGVVNYYYADKNNEIKEMVESAIAYIANHTCIRFNEDQNAVQRVQIRMQQNWLCQSTVGAPGMSMSKPIGELSMLVQSCDTIGSIVHEFSHSLGRFHEHTRPDRDNFMKVTTTVHEARPRPSGMTTMYGPFEHGSVMMYHADTYGPGTMDPLDMDYKQTMGNRRVTFYDMYKINQYYGCWCSKQLECKNGGYTSPSDCSRCNCPKGFFGNLCDERQQDSYELMAVNNLWQSITIPFAYKPEPGSDGFYSTFVYITGKANSTIEITLEGLQDVICTAGCTVNGVEIKFKEDSKITSPVVCCTDKPPYKNVFKSSHNPTIIELYSRTTLPSAVTFKYRFTNDKVVLG
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end (By similarity).
Domain:
Has 2 structurally independent domains; the N-terminal PINc domain which binds Mn(2+), rRNA substrate and probably has endoribonuclease activity, and the C-terminal zinc ribbon domain which also binds rRNA substrate.
Sequence:
MLSLPPPEFYKLWIINKSPYQLFNIYRSGIMKVKVLDASAIIHGYNPIIEEGEHYTTPEVLEEIESKKIIVEQALDFGKLKIMSPNREYIKKVEEVVKKTGDNLSQQDIGVLALALNLNAILYTDDYGIQNVAKKLNIEVRGIAFEPTNKDFIWRKICEGCKKLYPVDYEEDICEICGSPLKRKMVKSRLKKKRKKK
The following text describes a protein:
Function:
Hydrolase that deubiquitinates target proteins.
Subcellular Localization:
Nucleus.
Sequence:
MCSPDPEDMHILTNDIPSFDKSLDPYGPEGHLALDIERFSSFMNKPDSRIMSKPVIVRGIPWRILAICRHQQNNRQVATSRSRNNYNFGFFLQCNNDDLLQKRGMWRCYGQATLEVLNANGPPIQKKIHHSFHNTEVDWGFSNYDQYDTLTSPKDGYVIDDVIRLRCRFTADVPTGANYMWDSKKHTGCIGLRNQGATCYMNSILQSFYFTTGFRRAVYNMEVGTEPNESNIVLAMQRVFYELQMSSEAVETNSLTRAFGWDKLDAFNQHDVQEFCRVLLDNLETKMKGTSEEKSIPNLFRGNMKSYIKCLDVDYESSRTESFYDVQLNVLGMDSLERAFDAYTTPETLDDDNKYDAGDHGLQRAEKGVKFVELPPVLHVQLMRFQYCGVEQKINERFSFPEKMNLSNCCELGPMLNEEDCVYSLHAVLVHSGEFHGGHYVTYINVNLHESAVDPTATAKWCKFDDDVVSRTTTDDAIVSNFGGEKAMNSSAYMLVYVRDNAIDQVLAPIPDTQIPQSVSRTFEMERMHRNREKKKQEEEQMCMSITLVTPDILATNHSFDLIEPVTITDVLPHETVYKHMVTAELYQFVQEKLFEKSTLPKVDMFDSDDETRMKRKEILRRLKTKKFGFRLWRMTDSYTVDKPQKMASRLRPSDFIEYSIDTRLDHTLSHDTETIYVEHSQFLQPLNEYLPTRDILFFLKYYDAITDKFTIIGHVTLDSHKRLNLYRMTFCDLLGLPKDTELKYYIEHAPNHVEQIDDPNRSTISRLVDDQDGAIVIVEKADPTAKKDAKTKMIELYNDVEFEFSQQFYSKMPNEEPFELFTKRFCLEQKLTDVTEFIGSELNVDPRNVMLWTRVSGSRFEPNFDDYAVTGIQCKYLTLRTLHDPRQHKKYSVSYAIFPFPVNEVHTTRMFVRLYRQMPNGNVEELNLFPPKDGTVTDLIAEAKRYYPSVEGGSGKFRLLQIGTSPLNNQRVFQIYNENTAIVDLDQRPVYKQQAQHTLNCRIEEIPHDELDVAQGEFFCPVVHYDREPTKLFGVSFVIKIRNGELMTDVRDRLRRKLPDVSDAEFAKYKFALLSRDKLCRNIEFNAGEKVNLMDMANQTTGVPQVYIGLDHKSPSQHSNEAAIRILN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSSAEVPSNDIRFQMELEFIQCLASPAYLNFLAINRYFENPAFMNYLQYLKYWKLPQYAKYIVYPHCLAFLDMLDDERFRQMIAREDFMTLVHGQQFYHWQTFLNNRSEGKPEDAVSSAETPAATTTAETS
The following text describes a protein:
Function:
Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPEERADAARLLRGFERRFLAARALRSFPWQSLEEKLRDSSGSELLLDILQKTVKHPLCVKHPPSVKYSRSFLSELIRKHEAVHTEPLDELYQALAEVLTAEDPTHCHRSYLLPSGDSVTLCESTAIVSHGTTGLVTWNAALYLAEWAVENPAVFAHRMVLELGSGAGLTGLAICKTCRPRAYIFSDCHSHVLEQLRGNVLLNGFSLEPSIDTWAQHPGPHTPEAERPWVTVARLDWDTVTAPQLAAFQPDVVLAADVLYCPETVLSLVGVLRKLSTCRKDQRAPDAYIAFTVRNPETCQLFTTELGQAGIPWEEVPCHDQKLFPYEEHSEMAILKLTL
The following text describes a protein:
Function:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Subcellular Localization:
Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
Sequence:
MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHSSSFIGSALQDQASRLGVPVGILSAGMVASSVGQICTAPAETSHPVLLTVEQRKKLSSLLEFAQYLLAHSMFSRLSFCQELWKIQSSLLLEAVWHLHVQGIVSLQELLESHPDMHAVGSWLFRNLCCLCEQMEASCQHADVARAMLSDFVQMFVLRGFQKNSDLRRTVEPEKMPQVTVDVLQRMLIFALDALAAGVQEESSTHKIVRCWFGVFSGHTLGSVISTDPLKRFFSHTLTQILTHSPVLKASDAVQMQREWSFARTHPLLTSLYRRLFVMLSAEELVGHLQEVLETQEVHWQRVLSFVSALVVCFPEAQQLLEDWVARLMAQAFESCQLDSMVTAFLVVRQAALEGPSAFLSYADWFKASFGSTRGYHGCSKKALVFLFTFLSELVPFESPRYLQVHILHPPLVPGKYRSLLTDYISLAKTRLADLKVSIENMGLYEDLSSAGDITEPHSQALQDVEKAIMVFEHTGNIPVTVMEASIFRRPYYVSHFLPALLTPRVLPKVPDSRVAFIESLKRADKIPPSLYSTYCQACSAAEEKPEDAALGVRAEPNSAEEPLGQLTAALGELRASMTDPSQRDVISAQVAVISERLRAVLGHNEDDSSVEISKIQLSINTPRLEPREHMAVDLLLTSFCQNLMAASSVAPPERQGPWAALFVRTMCGRVLPAVLTRLCQLLRHQGPSLSAPHVLGLAALAVHLGESRSALPEVDVGPPAPGAGLPVPALFDSLLTCRTRDSLFFCLKFCTAAISYSLCKFSSQSRDTLCSCLSPGLIKKFQFLMFRLFSEARQPLSEEDVASLSWRPLHLPSADWQRAALSLWTHRTFREVLKEEDVHLTYQDWLHLELEIQPEADALSDTERQDFHQWAIHEHFLPESSASGGCDGDLQAACTILVNALMDFHQSSRSYDHSENSDLVFGGRTGNEDIISRLQEMVADLELQQDLIVPLGHTPSQEHFLFEIFRRRLQALTSGWSVAASLQRQRELLMYKRILLRLPSSVLCGSSFQAEQPITARCEQFFHLVNSEMRNFCSHGGALTQDITAHFFRGLLNACLRSRDPSLMVDFILAKCQTKCPLILTSALVWWPSLEPVLLCRWRRHCQSPLPRELQKLQEGRQFASDFLSPEAASPAPNPDWLSAAALHFAIQQVREENIRKQLKKLDCEREELLVFLFFFSLMGLLSSHLTSNSTTDLPKAFHVCAAILECLEKRKISWLALFQLTESDLRLGRLLLRVAPDQHTRLLPFAFYSLLSYFHEDAAIREEAFLHVAVDMYLKLVQLFVAGDTSTVSPPAGRSLELKGQGNPVELITKARLFLLQLIPRCPKKSFSHVAELLADRGDCDPEVSAALQSRQQAAPDADLSQEPHLF
The following text describes a protein:
Function:
May be a flavoprotein with enzymatic activity.
Sequence:
MSRTKSTKVLIIGAGVSGLKAAETILSKSFLTGDDVLVVEAQNRIGGRLKTTDTSQSKLGINYDLGASWFHDSLNNIVLNHMINDGLLDDEKDVYFDDKDLKTFSSTGEVPIVDKKLNRVLEDIEKYIQLYFNRNLGVPDLSLRDIVAQYFEKYNRLITEEQREYCGRMMRYLEFWFGISWDRISGKYAVTTHQGRNLLNKKGYGYLVESLAKRIPESSLLLEEPVNKIIRNNKDAGKRVLVETINGLQIFCDYLIVTVPQSILSLEESSPYSIKWEPKLPQRLVESINSIHFGALGKVIFEFDRIFWDNSKDRFQIIADHTDGDLSRELTELPKPFTYPLFAVNFGRVHNGKASLVILTQAPLTNYLETHPDQAWQYYQPMLQKLSINDEPIPDPINTIVTDWTTNPYIRGSYSTMYTNDDPSDLIISLSGDFEDLGISEPYIKFAGEHTTSEGTGCVHGAYMSGIYAADCILENIFRNDVTGYTIIG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDRPHLFSEVHFRRNASNPNQINWTRYWIDCLSSVPWNDISVTGFEYLAKKYGLEVFQDSSKPNEVVLSLAGKIILIDITVPINASPKDINVVLAFANASGEQYNNPVAEKLLKDAIYNCNTPLFEKNVKWLATFDHSSPSVQQSCFQYLDSLSSSLNAIYEAELSLLAQEENVIMHGNGKPLSNYEGQLGLRIVYWKLLDKTYSTQIFMDNLSHESLPHLLFGYNLLNSPPILQSSKINWALENTLTPIPTTMELVFDDINLIIPEQGVKPLLDLLHVHDITIPWPVQNYSHMLGLPSKSTVNYKFINKNQAIQLTGFDVSARSLRHVPFHHPKQIRGILAIVRQYLLLQLILENIKSADLAETAASSSLHLSLYFKEHPIVHAQYQEINKLNNSEQIIIVLSVLSDGRLNVDYMSSGGKELSKQQSHVFQKLIQQTCNIGLAIEVFIKKVVN
The following text describes a protein:
Function:
Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190. Cooperates with pita and cliff to recruit Cp190 and regulate insulator function at the front-ultraabdominal (Fub) boundary.
Subcellular Localization:
Nucleus. Chromosome. Note=Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies.
Sequence:
MSASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDEGGLDKDNESHSGDEEAVSVTGETKTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSRSKHAVELCSLLVDDIYGELSSRIFTILLRRGRLSMIALKRHTQLTTRQLKLGLTVLVRQNLVYHNSDEGADTNYEANIDAAYALVRSGKILEIAEERFGSVAAEIMGQLVLLGHAKVSDIIAELNKSHDTRANGNGINGATNGNGVHSYHSGQLNYILIQLLEQGFIQPVGRNMFRSPTDSYNAVEKALLHEDYGGATRGTKQKEELRSRIRQRLQDLRAEVPNWKPVGYNRPSANGHLNGTASKRRRLSHNGTASNGYDFGDDETNRLDGNLVLRINHEKCTVFLRNRRLVELANNRIGVTTSYIYAELLRLMAEQIPRCRRDPKIDDAVDDPDGPSIIITTQELTDALSKTINVSTGIGKATSENTDTSKLDKLQNGRKRKAREVEDDASSDEESEDDHKSFVNGNGHAMDIDDDPFADQPRVNTNKRAVTFQDQERAPPPTESRQARMMHVMSHLQLLAADDCHLLRKCGSRQMGEWTVDFERVVERLRELEIDSIIYENFGQIGHRLIRVMRKMGKLEEKHIAKVALVKQQDSRTKLVEMQMHGMVDVQEVPRDAGRMIAFFRIINHDSGFGLVLERS
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MSTNPNTPAPPASRTNPISLRIYKAIGTSFDDVSSREALEIASGMYGPEDPKAKVKAQPEYEELEEDDDTLPKRRTLKGQSAAIARKYLKQDIETCLATGSTKFLEAFAEVDQKLNVLREHMQEMQVRCDQVQSELDQANSGTKFLLERADVLRSQRDSAQLRAHLITLFLSRFTLSNSELTALTSREVTIGQPLFDALDHVEKIRTDCEVLLSGEEGKAQAGLDIMSLTSEQLESGYSKIHRYCQFEFRQFTREAQLEASSVMRQAICRLRDRPALLADAIQTLTSTRQSSILHQFLDALTRGGPGGLPRPIEIHAHDPTRYVGDMLAWVHQTTATEHEFLEGMFGVKEKKRWVGQERGGEEGEEERMASEVLDKDLEGLSRPLKLRIQETIKSQEGIIMTYKIANLLHFYLVTMRKTIGGKAMLVQTLQEIHDQAYIAFYETLDAQGRGLLRFLHPPDATLTPPITLRDAAQILRELLFVYSTSLIDPAERESDADLAKLLDKAVGPCVEMCERMAEMRRGKSGGGEWERDIFMVNSLGYLEHTLEMYDFTTKTLHMLDEKIKTHVESMTFEHHGKLLESCGLAAVMRTIRTRPEDTPLSRLHATSPKSLTSALSKFSTWISTVDPSTSPRLALLTSPRLAVEIHRKALRKIYDAYGEICERVLDKAEGYEFGETMLRRGRDEVGVALGVGEDWELEEDTEEKSMKQKEQQDEDTEDQGEKGIMQEEHKAQDAGNTEDKA
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQRDDGFVYCYGNLYSLLLYWGLVTIRVRSPDRGGAFSNRWTVCYALFTRSFMVICFMATVMTKLRDPEMSAAMFGHLSPLVKAIFTWECLSCSVTYIEYCLSLDLQKDRHLKLVARMQEFDRSVLMVFPHVQWNYRRARLKYWYGTVIVGFCFFSFSISLIFDTTRCTCGIPSTLLMAFTYTLLTSSVGLLGFVHIGIMDFIRVRLRLVQQLLHQLYQADDSSEVHERIAYLFEMSKRCSFLLAELNGVFGFAAAAGIFYDFTIMTCFVYVICQKLLEREPWDPEYVYMLLHVAIHTYKVVITSTYGYLLLREKRNCMHLLSQYSRYFSGQDVARRKTEDFQHWRMHNRQAAMVGSTTLLSVSTIYLVYNGMANYVIILVQLLFQQQQIKDHQLTSGKDVDIVGPMGPITHMD