lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular Localization:
Nucleus.
Domain:
The SBP-type zinc finger is required for the binding to DNA.
Sequence:
MDCNMVSSFPWDWENLIMSNQSKTENEKKQQSTEWEFEKGEGIESIVPDFLGFEKVSSGSATSFWHTAVSKSSQSTSINSSSPEDKRCNLASQSSPGDSSSNIDFLQVKPSTALEVPIASAESDLCLKLGKRTYSEEFWGRNNNDLSAVSMNLLTPSVVARKKTKSCGQSMQVPRCQIDGCELDLSSSKDYHRKHRVCETHSKCPKVVVSGLERRFCQQCSRFHAVSEFDEKKRSCRKRLSHHNARRRKPQGVFPLNSERVFDRRQHTSMLWNGLSLNTRSEEKYTWGTTYETKPTQMESGFTLSFQRGNGSEDQLFTGSTLSFSAFQTSGGFSAGKSNIQLPDKGVGECSGGLHESHDFYSALSLLSTTSDSQGIKHTPVAEPPPIFGTFPSHFI
The following text describes a protein:
Function:
Acts as a specific inhibitor of subtilisin-like protease SUB1.
Subcellular Localization:
Secreted. Parasitophorous vacuole lumen. Cell membrane; Peripheral membrane protein; Extracellular side.
Sequence:
MKFLFAFNFFSLYIYLYEFLCIHLCGSQVTPAGTVLNSNSALISRRINRRKMKNCNNNDLLKVLKMETTYNELPAHNLLMSSKNDINKLFDYINKNEELSKLMNSCGTYVYLKYLGVVIFSIKENVQISHLSEFIQYLLNKNVCIEFNQNVML
The following text describes a protein:
Function:
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations. DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB. Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H. The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D. There are two branches to synthesize asnovolin A from chemesin D. In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A. In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate. Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction. The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization. The following step utilizes the ketoreductase nvfG to produce fumigatonoid B. The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C. Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGSLHDYVLIITGSASGIGLATATIALDEGARVLGVDISSPPRSLIDHSNFKFVEGNLSLEPTPRRVVEACVKAFGGRIDGLLNIAGVMDLNQSVDSLSDTMWESCIAINLTAPVKLMREVIPIMRQQKSGSIVNVASKAALSGAVSGVAYTASKHGLVGATKNVAWRFKQENIRCNAVCPGAVDGTSIHRGLETSQFDSEALGTMSLIHEAHMRDRERGIHIQPEDIARSLLFLVSSRSNGINGAIIPIDNAWSTI
The following text describes a protein:
Function:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Localization:
Secreted.
Sequence:
MKACVCFLLMCVLAAQAEESPKILTLSKVMNELKKIQQGLTNSNKTWFNSPATNDLKDCCVASALECFRSKVLHLSVSDEKLKKSQRSVHHELRKSFIVDSVSCTPQETQKAQCKSCEAYTMVNSRTFVDNFKTLLQKRSMPVKRRDLKSL
The following text describes a protein:
Function:
Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MDWRVRGLCLTEDPDLFFPIGGLNSGPAAIQTDEAKAVCRHCPVTRQCLAWAVDVGPVEGIWGGTTEGERRALRRRAVRASRATESAA
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSPKTILVFDVDGTLTAARQGITAEMREFLAETRKRVPLAVVGGSDFKKITEQLAGHDRDLLLSSFDYVFSENGLLGFKGTDAFPVQSIQKAIGDEKLQELINFALRYMSEIRLPKKRGNFVEFRNGMINLSPIGRSCSQEERMEFVKFDSENGIRLKFAEELKKNFGKCGLQFAIGGQISVDVFPTGWDKTFCLQYFENDYDVIHFFGDKTAPGGNDHEIFADERTIGHTVEGPEDTRKQVEAVLNAI
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSLVTSLTYVLPHRLLSSLARALAYSKSPATKQWLIDTVTRKFGVDLSEAQEPDPRVYPTFNAFFTRALKPGARVPDADPQALLMPADGRISQLGPIENGRIFQAKGQSFTAAELLGDESAAVPFHNGLFATVYLSPKDYHRVHMPWSGTLRETVHVPGRLFSVGPDAVRNVPRLFARNERLVCHFDTDFGPMASVMVGALLVSGVETVWSGVEIPRYGDRITRKDYRGKGITLERFAEMARFNYGSTVIVLLPPGVAALEGGLAAESSVRLGQALARRQVA
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRTTGHGSVWVTLKHSSDKSKAQRNKMKTAGKNIEFKCLIRATGGKKNISIMVITVASSFLILFHCSVLLVGLWLCLLCKSCHFPLSFCFVGFYVLW
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MALHLTLARPYAKAAFADGQKANQLEAWLAVFTAFSKIIKNKEVARQIINPKFSDKEIKTLLFDLIQTIEPESTKQLKDKIDHFLQLLIDEKRLMILPDIALVYQQLLNKYQGIIEASVTYVFPLNDEHRQQIQKQLEKRFNAEVKLKMIKDESLLGGVIIRAGNWVMDGSIKGKLTRLAENLKG
The following text describes a protein:
Function:
Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); The methylation of Alka by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene and other alkylation resistance genes.
Miscellaneous:
MISCELLANEOUS: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.
Sequence:
MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFARNVRFLPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNLPFGDVAFAAGFSSIRQFNDTVRLACDGTPTALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVRDGAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQEKIA
The following text describes a protein:
Function:
Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Cytoplasm. Photoreceptor inner segment.
Sequence:
MLSFFRRTLGRRSMRRHAEKERLREAQRATTHIPAAGDTRSIVTCRVSLLDGSDVSVDLPKKAEGQELFDQIMYHLDLIEKDYFGLQFMDSAQVPHWLDNTKSIKKQVKIGPPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLECPFDTAVQLAAYSLQGELGDFDPTEHTPDLVSEFRFIPTQSEEFEFAVLAKWKDFRGQTPAEAETNYLNKAKWLEMYGVDMHIVKARDGNDYQLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKSKLTLVVVEDDEQGKEQEHTFVFKMDHPKACKHLWKCAVEHHAFFCLRSPTQKNSSRSGFIRLGSRFRYSGKTEYQTTKSSKPRRSSSFERRPSKRYSRRTLQMRGQAQRPDFTRSQRDQPGQTNGSQQAWPPNPSVSPSGAALLEIQNLTRSPGAGQGDRWPSGAPGVIEDSRSGRRPPAAALVADRSYSHFVHEQNAKNAGKAMELRKLPPGIHLTEL
The following text describes a protein:
Function:
Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MMMVPLETMVSLAIVEREKVYMPSAFRTAASPFDTPMPSASLFLSLSLDGSGASQKPVMLTDVQATMEFIAVAEVAVIGFFQDLEIPAVSLFHSMVQKFQDVSFGISTDSEVLGHYNITGNTISLFRLVDNKKLDLESKYIESIDATKLSRFIEINSLHLVTEYNPATVIGLFNSMIQIHLLLMMNNASPEYEESMSRYQKAAKLFQGKILFVLVDSGVEANGKVISFFKLKKSQLPALAIYRTVDEEWDTLPMAEVSVEHVQNFCDGFLKGKRLRENHESEEKTPKVEL
The following text describes a protein:
Function:
Is essential for optimal growth.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MAYDVARVRGLHPSLGDGWVHFDAPAGMLIPDSVATTVSTAFRRSGASTVGAHPSARRSAAVLDAAREAVADLVNADPGGVVLGADRAVLLSLLAEASSSRAGLGYEVIVSRLDDEANIAPWLRAAHRYGAKVKWAEVDIETGELPTWQWESLISKSTRLVAVNSASGTLGGVTDLRAMTKLVHDVGALVVVDHSAAAPYRLLDIRETDADVVTVNAHAWGGPPIGAMVFRDPSVMNSFGSVSTNPYATGPARLEIGVHQFGLLAGVVASIEYLAALDESARGSRRERLAVSMQSADAYLNRVFDYLMVSLRSLPLVMLIGRPEAQIPVVSFAVHKVPADRVVQRLADNGILAIANTGSRVLDVLGVNDVGGAVTVGLAHYSTMAEVDQLVRALASLG
The following text describes a protein:
Function:
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MISITEWQKIGVGITGFGIFFILFGTLLYFDSVLLAFGNLLFLTGLSLIIGLRKTFWFFFQRHKLKGTSFFLGGVVIVLLRWPLLGMFLETYGFFSLFKGFFPVAFGFLGNVCNIPFLGALFRRLQGTSSMV
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MTDGHQFNNISLGGRGGTNPGQLKVQSGGILWKKQGGGKAVEVDKEDIVGLTWMKVPRTNQLGVRIKDGLYYKFTGFRDQDVASLTTYFQNTCGISPEEKQLSVSGKNWGEVDLNGNMLAFLVGSKQAFEISLADVSQTQLQGKNDVMLEFHVDDTTGANEKDSLMEISFHIPNSNTQFVGDENRPPAQVFRDKIMSMADVGAGGEEAVVTFDGIAILTPRGRYNVELHLSFLRLQGQANDFKIQYSSVVRIFLLPKHNQPHTLVVITLDPPIRKGQTLYPHIVLQFETDNVVDLSLALSEDLLNTKYKDRLLLGYKGLIHDIFTQILRGLSGAKVTKPGKFRSSQDGYAVKSSLKAEDGLLYPLEKSFFFLPKPPTLILHEEIDYVEFERHAAGTANMHYFDLLIRLKTEQEHLFRNIQRNEYHNLFDFISSKGLKIMNLNEARATEGVPVLPDEDDAVDPHLERIKNEAGGDDSDEEDEDFVLDKDDGGSPTDDSGGDESDASDSGGEKEKPAKKPKKEVTVSKPSASRKKADDDGSKKKKQKKKKDPNAPKRAISAFMFFSQSERESVKKSFPGITFTETGKVLGERWNKLSAEEKEPYEAMARADKKRYSEQISGYKNPQSTAMDSGNESESS
The following text describes a protein:
Function:
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MTCVEQEKLGQAFEDAFEVLRQHSTGDLQYSPDYKNYLALINHRPHVKGNSSCYGVLPTEEPVYNWRMVSNSAADFYFEGNIHQSLQNITENQLVQPTVLQKKLRLFEYLHESLCNPEMASCFQWVDITKGIFQFVSKNKEKLAELWGKTKGNKKTMTYQKMARALRNYRGSREITKIWRNEAILQRLSPSYFLGKEIFYSQCVQPDQEYLSLNNCNANYNYTYANYHELNHRDC
The following text describes a protein:
Function:
Mediates magnesium influx to the cytosol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRKLEKTDANRSNNKKPFAIALEAKNSLEQTLFKLNTHLNGLTEEDARERLELYGINQVAHEKAPPAFLQLLAAFNNPFIFVLIILASISFFTDYWLPLQEGGETDLIGVSIIVTMVLISGLLRFWQEYRTNKAAEALKSMVRTTATVLRRGHYGAKPTQQEIPINQLVPGDIILLSAGDMIPADLRLINSRDLFVSQAILTGEAIPVEKYDAMGCVSSKSVDAGAGSEGELLELSNICLMGTNVASGTAMGVVVATGGHTYFGSLAKSIVGTRAQTAFDRGVNSVSWLLIRFMLVMVPIVLLINGFTKGDWTEAALFALAVAVGLTPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEHHLDVSGCNDNKVLQLAWLNSFHQSGMRNLMDQAVIKFSRGKPEIEALRNFNKVDELPFDFIRRRLSIVVKDAQQQQHLICKGAVEEMLSICTHVREGDDIFPLDAARRATLQALATQYNEDGFRVLLLATRELGAQVSPVPLNIDDERDLVVQGLLTFLDPPKESAAAAIAALRENGVAVKVLTGDNPIITAKICRDVGLEPGEPLNGRDIEAMDEATLAREVELRTVFTKLTPLQKSRVLKMLQSNGHTVGFLGDGINDAPALRDADVGISVDTGTDIAKESADIILLEKDLMVLEAGVIKGRETFGNIIKYLNMTASSNFGNVFSVLVASAFIPFLPMLAIHLLLQNLMYDISQLSLPWDKMDKEFLRKPRKWDAKNIGRFMLWVGPTSSIFDITTYALMWFVFAANSVEHQALFQSGWFIEGLLSQTLVVHMLRTQKIPFIQSTAALPVLLTTGLIMAIGIYIPFSPLGTLVGLEPLPWQYFPWLAGTLICYCVVAQLMKRFYIRRFGEWL
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MALTLDIVVCCLRKTIFSPYLAISIPVVLHLHSISSRLVLIVSYFWGVVICFIRLLCYADWRYANQAPWFHAPPKLQWEDQVVLITGGGSGIGALLAQTLANRNVAVAILTKDLPKQPFSHSHIHVFACDVSDYNAVMGVSARVREAVGDPTIIINNAGIVSGKLLLDLTEEDITSTFGSNTLAHFWVLKAFLPAMLRRGRGHIVTMSSILGIVGAAQMTDYCASKAAVLSLHQTLRFELDSRYQTPGIRTTLVLPAYTLTSLFNRVKLPTNRLFDFLCPPVQPRAVVEHIISALDDNESRIIRLPFYSNFARLCGDAVGLVPAGVRDFVQWLSGADYAMKGYGPTPDAGERLLAERQSHTPLNRKRTE
The following text describes a protein:
Function:
NAD-dependent deacetylase. Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased life-span. May also regulate life-span independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticulum (ER). Acts upstream of the nicotinic acid metabolism pathway, which may be linked to the regulation of longevity. Plays a role in ascaroside-mediated longevity and stress resistance.
Subcellular Localization:
Nucleus.
Sequence:
MSHESHHSEGMATSGEVHEIREEEPEIETMHIENSVEGESGRQRTESTASVNSESWQNSDEMMMNMRRAQSLLDQGASCFQIIQQVFPEFDASRFENMSERVHFKVLSDLLERAPTRQKLFTYNSLSDAVDLFRTRKNILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPNLPDPTAMFDIRYFRDNPAPFYNFAREIFPGQFTPSVSHRFIKQLESSGRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTSCGNQTDGMEIREDVLAMKVARCKICHGVIKPNIVFFGEDLGREFHRHVTEDKDKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNCDDIVRDICYALGGSFAEMIASYDACVERSPSTSRAKRQLITQQEFLNICAQERRDKTPVPEPESSEPSTKRPRMSTTEDMEGNQFQQIQKHTSSEDDDEDNTRNSDEVLREIKHPRLISITDMLNDKKCVAISAYQTVFPGAECSFDMETLKLVHDVPHRNRHESDSSCESCSTVPGSDKSEANPLSRSQSTDDIVYAEIRRKEVFLDLQRCDSCDNDLQYELSDPIDPETFAKRIADMCIE
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence:
MPDNTDPNTKDGQPAPSILTSKFAKLNPFSKTGASDPEGGGDNLGEEVDFDSIAGGGHAARRTKITKSELRISHALRHFLVQENLISPADALLDQPRASSSDALKAFVDQSHINVPEYVRDRSRPLSEYFVSSSHNTYLLAHQLYGSSSAVAYEHVLIAGARCVEIDAWDNEDDPQEPKVTHGYTLASHVPFRAVCETMKQAIQKEQDEAQRDHSFKVAPILLSLENHCGHAGQKRLVEIMHEVWGDLLISGPVDKNEPASEHTALDHLGAKIAVMVEFYPSEQPPVAEEQDSDDQEEKKNKAKRNEAKKAGIIPELCSLGVYAQSVKPVNDSWYAATLTNGPHDHLINISETGLLDLLPKHSTAIKKHNAQHLMRVYPKGTRISSKNLNPVPFWGVGAQVCALNWQTFDHSMQLNEALFSGSDGYVLKPPGLRIGGDGQTSLGRHKLILYIAGATDLPLPAGRDADEIRPYVTCTLILPSDLDSEPPKEKTKPYKQHKLGIIHKGEQPIPTDALWNEQLEWEFEHDELAFVRILIKSDDKFARNPLFAVAAVRLVYAAQGWRFIRLLDLKGRETHSTLLVKFELEKL
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MPATTKSKKRKTPVRRKTQQIGTSTRGQICNSAKQGGRVAQKSKKHPADSKKLTKRTQTLGRTLRRRGSDDVCPNQDLRKSQAINATVNTRLRRSSGLPETKLQAPSGRRRSLRETHLSVTPSLKQKRGRKTSSESGAAPQHQNTKRQTSSTSINESSFDEEKAKDSHTNEELSLLCAEANVPAGIKDQSLGVGDTKESGASKVPSPEGTDMLDDSLPLGCDRHAAHQDQKTVISDGDSDSKHVSGHPVCVETDEQPTLCSGGSKDCPSGTSELTSSSGVQDSNGNGNLSFPGNESDLLANDHKPDGAFSLQEEQGNVLGTKGKPMDESVSVRQEIEEINYERGGSLQEETATETQQETVEEMEGTVERLGNCEGEAKRGEIIENRVSGGPTDSQISLPARQTPHPLSSNNQLAAQSDLPAPALLFSNQTTSSPTKVLCTSEDLSQHKTDVIPVTDGAKLLVPGSSAVPDTALTVQTVIVKRNMPVIVHRDSLKPMSFGENSFGGSFQFQRSVIPQPQGERGTRSTAETKDLDFQQHGFSCQKEAFPPPFPQPGVAPSEPTDTFEAGMPEQDLVPKTSAPLDSSSTFSCSSESTRSSFSFDTESESGYGEPTPSTLSERWGQEEAGLLFSSSPKLKRKERKKRNRCGTCEPCLRKINCGLCSCCLNRRTCHQICKLRKCVELKRRKPSSSPGFSAKEVIPESGSVNGKSKAQMEDTHMAAEEDEGEEGHIPHTQTTLVSQSLVHNLALDLGGRAALIKSEAGLERTSFALHRCLSSFSNVPNGSVENPLRANGANLTRGPDLKSTCKRTLEPERSTITKRTSENGPKTPADDMLAPLKRIKQEEPWAWITEQSAPVLRDDDHVCEDPLSTLAAVVCLSVTERRGLEEKLFSRRSSILRSIKTEPPDLHFVKKEENYLNDDWCPKSTPLNTKRTPHTIKCEPSPSVLLPSVQYLAERRNLSFDQAVAIEALTQLAAIPQSAQGAIKPENNHEHHMSTASTCSNSKTNTALQEAKPMSAICYNKVSVISSPLHQMSVIRPPVARQGNVIQCSRGLNPDTKVLVPDRLEKISRDRTAFRLGERGNASHSIRLDSSQMKFSSAHDQLSQVDGARSQSKVVRNSDEEEVAAQLADLAFIIQSRHNQQSENNPPKGTPVSAIKYNNNHKLQLQSLSQKNPLARKQKSTPSKPRKRKSDGLQEPHNRRTPLSKRMPNGEIPHRGKGHKSLQQGKSGPHLKNNLFLPQAQIDLKKYLAAAQEERSNVHGASLFGQQTLNLSTLTKSNHDSGQENHPWSFSNGPLHKHNTCNGYAAGPDDVSSQVGKPCGGLQNTSIEKTAFPSHSTGHHSWANGFSRTPQSPPPSQQSYYKLERSGPVAVLSTATDGVQDHSAESTPTKNNINNFLESPMSYLDTPTKNLINTPSKKLADLPSCQCVDQIIEKEEGPYYTHLGAGPSVAAVREMMENRYGAKGNAIRVEVVVYTGKEGRSSQGCPIAKWVIRRGSEEEKLLCLVRQRPGHSCDSAVLVILILAWEGIPRPVADHLYRELTDTLFKYGSPTSRRCALNEDRTCACQGLDPDTCGASFSFGCSWSMYFNGCKFARSKVPRKFRLHGDFPEQEEKIENNLQNLASDLAPLYKKLAPQAFQNQVEHEVAGSDCRLGREEGRPFSGVTACVDFCAHAHKDTSNMNNGSTVVCTLTKEDNRAVRNIPEDEQLHVLPLYKVSDTDEFGMVEGQWAKIQSGALQILSAFPREVRLLAEPVKSARKIRQEARLKAQAEKMEKKLGLSSPSPAKVKTEIASKDYYSAYRPPPRPSTAEKSTPERSQTSAYSQGTSSCSTSGVPPQRGVISSNHHGLPDLQFGQNGSVLNCRIAGDPIDGHCPAPGELGTPVEHMIPTQNDYLFKTEPNKVHCSPLDRLPPSGPPPSSFSPRPTSEGLFSRLNGLHGAVGEVRGHGFPPGLPPPQPTPPTEAELLKQEEVWSDSEHNFLDSDIGGVAVAPSHGSILIECARRELHATTPILRPNRSHPTRISLVFYQHKSLNEPGHGMAMWDAKMAKRERDREEEAERSRIEAGLGKDGKDGKERREEDAGEATRRIMNVPTRQAWTLPRDGVITVSPYALTQVTGPYNRWT
The following text describes a protein:
Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
Subcellular Localization:
Secreted.
Sequence:
MPGAALPSLLAWLAVLLLGRARPADACSCSPIHPQQAFCNADVVIRAKRVSAKEVDSGNDIYGNPIKRIQYEVKQIKMFKGPDQDIEFIYTAPSTEVCGQPLDTGGKKEYLIAGKSEGDGKMHITLCDLVATWDSVSPTQKKSLNQRYQMGCECKISRCLSIPCFVSSSDECLWTDWAMEKIVGGRQAKHYACIKRSDGSCAWYRGMAPPKQEFLDIEDP
The following text describes a protein:
Function:
Couples proton uptake and Na(+) efflux to the substrate-product malate/lactate antiport, in an electroneutral malate-2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFIAMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLEFIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGAYFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNIDLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQGMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGVLKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDRRVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYTGKFIWYTKNNTVKAEKLG
The following text describes a protein:
Function:
Probable transporter involved in the regulation of zinc homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MTQNHNIPTAIQIQNPINNNVSVTISDQLPKPSANNPNLLSVDTRPTHRKGHHHKHSLSHQYFLPPKNRQPLEIPASYPIPTFKETFAILTFPQKLKLTSSILFFLVAVGVLLSGDATILLTLSCSLIVEGVLIIINVWRETLDSFLVWRHTCLRYPFGMQQMELLVDFSFSILLIFLGMNLLKEPAEHAIEDWGNLHHAGDHEEETVHIHLTISLFASAIISGFALLLDHPSAHIRELNSRFFHGLTLVPSLILVLLLSLGYQVGSFLSHLLSLTIAVTALVNGFSIAKSLALMLLLTYSNKEKVFECVSLIKEDTRIDQLNYAAIWQPHYNTCIANIGLTVSGGEREQAAVREDIIRIIQKTVGSIFGAGVQPKWEISVDIQRA
The following text describes a protein:
Function:
Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLKQLQMGLRAFLVLASKIWTFICFVFRKNTRAVIQHQTVKYEVSPLSPLSKHRLSMVRRKILVLDLDETLIHSHHDGVVRQTVKPGTPPDFVLKVTIDRHPVRFFVHKRPHVDFFLDVVSQWYTLVIFTASMEIYGAAVADKLDNQRGMLQRRYYRQHCTMDYGSYTKNLEMISMDLSSIFILDNSPSAYRSYPDNAIPIKSWFSDPMDTALLNLLPVLDALRFTQDVRSVLGRNLHSHRLW
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MFKVPVGLASRTRELMNSVTLNSLNNGKGFNMYLPGILRAFPKPVPSAITSPAIPKYRGESFQFRKLSCISSNYCSTTHQFLSSLKSSTSRLVGKRAFHSSRRAEIKFIFSSKSPKNGNKPFVKVYKVSPFFIIFATASIFTFILTSTIVVIPLIFHFFFPLLIMFFFFKQFKKWQKNIFYKDVLTSLPKTKLKITLPTMRSLQLQPMVQSWKEISSRMGIPNEFAKGLNVDLVKQEETRKQFLSFLQKRVLESFTKNELGIRSYFLGDSVEKWIKESYDLELDIDNCRSELRKFQTFIFSSVRYKLYLDSMKNLPLNPSKKLEGKKHIADVYVIILDESFPAIMFNGGAYSKADFFKILQESETSNSSKTLNTIIAIKSVNTLLSKHFVITTNGDSGEFFSKYNISKINDKNTEYTLKE
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MRLHYLLFVFLILFLVPAPGDAFLPKTLRKFFCRIRGGRCAVLNCLGKEEQIGRCSNSGRKCCRKKK