lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
S1 region attaches the virion to the cell membrane by interacting with host ACE2, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly.
Domain:
The KxHxx motif seems to function as an ER retrieval signal.
Sequence:
MKLFLILLVLPLASCFFTCNSNANLSMLQLGVPDNSSTIVTGLLPTHWFCANQSTSVYSANGFFYIDVGNHRSAFALHTGYYDANQYYIYVTNEIGLNASVTLKICKFSRNTTFDFLSNASSSFDCIVNLLFTEQLGAPLGITISGETVRLHLYNVTRTFYVPAAYKLTKLSVKCYFNYSCVFSVVNATVTVNVTTHNGRVVNYTVCDDCNGYTDNIFSVQQDGRIPNGFPFNNWFLLTNGSTLVDGVSRLYQPLRLTCLWPVPGLKSSTGFVYFNATGSDVNCNGYQHNSVVDVMRYNLNFSANSLDNLKSGVIVFKTLQYDVLFYCSNSSSGVLDTTIPFGPSSQPYYCFINSTINTTHVSTFVGILPPTVREIVVARTGQFYINGFKYFDLGFIEAVNFNVTTASATDFWTVAFATFVDVLVNVSATNIQNLLYCDSPFEKLQCEHLQFGLQDGFYSANFLDDNVLPETYVALPIYYQHTDINFTATASFGGSCYVCKPHQVNISLNGNTSVCVRTSHFSIRYIYNRVKSGSPGDSSWHIYLKSGTCPFSFSKLNNFQKFKTICFSTVEVPGSCNFPLEATWHYTSYTIVGALYVTWSEGNSITGVPYPVSGIREFSNLVLNNCTKYNIYDYVGTGIIRSSNQSLAGGITYVSNSGNLLGFKNVSTGNIFIVTPCNQPDQVAVYQQSIIGAMTAVNESRYGLQNLLQLPNFYYVSNGGNNCTTAVMTYSNFGICADGSLIPVRPRNSSDNGISAIITANLSIPSNWTTSVQVEYLQITSTPIVVDCATYVCNGNPRCKNLLKQYTSACKTIEDALRLSAHLETNDVSSMLTFDSNAFSLANVTSFGDYNLSSVLPQRNIRSSRIAGRSALEDLLFSKVVTSGLGTVDVDYKSCTKGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGMVLGGLTSAAAIPFSLALQARLNYVALQTDVLQENQKILAASFNKAINNIVASFSSVNDAITQTAEAIHTVTIALNKIQDVVNQQGSALNHLTSQLRHNFQAISNSIQAIYDRLDSIQADQQVDRLITGRLAALNAFVSQVLNKYTEVRGSRRLAQQKINECVKSQSNRYGFCGNGTHIFSIVNSAPDGLLFLHTVLLPTDYKNVKAWSGICVDGIYGYVLRQPNLVLYSDNGVFRVTSRVMFQPRLPVLSDFVQIYNCNVTFVNISRVELHTVIPDYVDVNKTLQEFAQNLPKYVKPNFDLTPFNLTYLNLSSELKQLEAKTASLFQTTVELQGLIDQINSTYVDLKLLNRFENYIKWPWWVWLIISVVFVVLLSLLVFCCLSTGCCGCCNCLTSSMRGCCDCGSTKLPYYEFEKVHVQ
The following text describes a protein:
Function:
Poor transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF target genes (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity.
Sequence:
MIDSSKKQQQQPPQHYSFADILSAGDLDPLKEKEWLDPGSQKSLKEVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPNRSELVRMHILEETLAEPSLQATQLKLKRARLADDLNEKIAQRPGPLELVEKNILPVDLSVKEAITVSQTNLPENLDTLSFDEDSSDALSPEQPASQESQGSAASPGEMKTSDSSSPVSNTTIQCQTVSSPLPDFFKPVPTADLTTRSPLSCIVSKPGPALIKQTQPKHTEKPRSKKSKDPKPRVKKLKYHQYIPPDQKGEKIEEEMDSNYARLLQQQQLVLQLQILSQQHSTLTTSRKSYPAPLKSQKKQNTINTTICNGNAGAPPAQCSVNRQNSVPCKKTGPLPSSLDDMKVAELKMELKLRGLPVSGTKMDLIERLKPFQDFSSNGVSPSSANTVNITNPACNTTDDATTAFSTSALINSSSPTPSVSIGNNQTMLDGINSPLPMSPTPSEQSNFSSEDTNITDTFAEILTMMSPSQFMNTSPLKVNEDSMGATPGNTPNVELDAVEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKKQLELEKRGQQQQPCSNVLLKMEPKHFNLQIKEETEAPDCQNSKQPVGSGGQILGQATAATISQNIIANNAVVIKHEVPLAKPEHQNVIQQFYVTSQRPPQTAVVAQPQALLATQTAQLLLPLSIKAANGVQLSMVQAQPHTVNPAPAQLSTAAATTTTLLSAPPKQSAPPTQDKFTPHLLNQNQQIRKLCPSATSGNVFSYPQNPVTAVPQSFSASISTSAQPQRSTQLTAVQNGPTSLHEKSSTPPQLQQFIVQQHPLFSSPTTKSKDPPRYEEAIKQARNNPASQPEVSNAHSQQMDDLFDILIKSGEMSPLIKEPSPISKMRPVTANVTTMPVNTVVSRPPPQIHMAPPLSLESTNSLSVSLESQLEAFLDGTLPSGNNIPHLESNSDDRETFSLIDDLNNDLLQNTAMLEHESTPMETTDTPFTANSCLSLDLADANLDNMEWLDLTMPNSSSSLTPLSSTLPSMFSTDFLDSNDLHLHWE
The following text describes a protein:
Function:
Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase.
Subcellular Localization:
Nucleus.
Sequence:
MQFEERLQQLVESDWSLDQSSPNVLVIVLGDTARKYVELGGLKEHVTTNTVAGHVASRERVSVVFLGRVKYLYMYLTRMQAQANGPQYSNVLVYGLWDLTATQDGPQQLRLLSLVLRQCLSLPSKVEFYPEPPSSSVPARLLRFWDHIIR
The following text describes a protein:
Function:
Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton.
Sequence:
MVIENTKDISINTGYKRQEDALNTDSEDLIYRPKKIIKTNQEDAVHDLKYENFVSKNHVLQSDINGKKRDSNRDKAAVVTAPIASTHESNYEESVSKFKESWLPQLKDLIESHKTICESTLAYESDQAMASSNTLKRIKDLKSKPKNIIQLERLHMLSNGEHRLLSKDETDDIESAYLNLRSHLQVQEQVYAEKDHEYSLQLQSYREAAEKAKQDILETKENLSSELSISNIQLKEAKERLEAANASYQKLRREHKELALYHEKKTHSLVCNLNGERKSFGDFVENEVKSYKHEYANICESLRRALVLIQGSCTEKILRFKEKILDLLEMKQQEENDRISHIEYENDLTVKKLKRRISELEMAVKEYESEKSYSEKEYEEKISSLRIELEDKLAEIDMLRNKLLKEEHKHHSTSEKLEELSKYVASIQDKERNNGQNALELQARIQQLERRNEDMYNKLLAEEIIRRKLHNDIQELKGNIRVFCRVRPLLPSEESEYCIADVLQFPDKDALEPQKLILKGPNVESSLGHTYDRNYEFSFDRVFAPESDNSSVFEEISQLIQSAIDGYNVSIFAYGQTGSGKTYTMSSQDGMIAMSIKHIFNYLSTLREKGWVYKLRGQFLEIYNETIYDLLNKAEMLKNPKHDIHHDEKERRTTVDNVSIIDFNEEDTVYKMLNRAGENRFIAATKANERSSRSHTVFMLYIDGENSRTKQICKGTLNLVDLAGSERLSYSQAVGDRLRETQAINKSLSCLGDVIHALGNASNSTTKEKSHIPYRNSKLTYLLKYSLGKGAKTLMFVNVSPLKSQFMDTLNSLRFATKVNDTKVGSIKHYKR
The following text describes a protein:
Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY
The following text describes a protein:
Function:
Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (PRPP) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). The enzyme favors polyprenyl phosphate with 50-60 carbon atoms, is unable to use C-20 polyprenyl phosphate, and uses C-75 polyprenyl phosphate less efficiently than C-50 or C-60. Cannot use UDP-galactose or GDP-mannose as a sugar donor. May play a role in ethambutol (EMB) resistance.
Miscellaneous:
MISCELLANEOUS: Overexpression in M.tuberculosis control strain H37Ra leads to ethambutol resistance.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Each protomer forms two helical bundles, which, alongside the bound lipids, are required for phosphoribosyltransferase activity in vitro. DP and PRPP bind the intramembrane and extramembrane cavities of Rv3806c, respectively, in a distinct manner to that of UbiA superfamily enzymes. PRPP binding induces conformational changes of the active site.
Sequence:
MSEDVVTQPPANLVAGVVKAIRPRQWVKNVLVLAAPLAALGGGVRYDYVEVLSKVSMAFVVFSLAASAVYLVNDVRDVEADREHPTKRFRPIAAGVVPEWLAYTVAVVLGVTSLAGAWMLTPNLALVMVVYLAMQLAYCFGLKHQAVVEICVVSSAYLIRAIAGGVATKIPLSKWFLLIMAFGSLFMVAGKRYAELHLAERTGAAIRKSLESYTSTYLRFVWTLSATAVVLCYGLWAFERDGYSGSWFAVSMIPFTIAILRYAVDVDGGLAGEPEDIALRDRVLQLLALAWIATVGAAVAFG
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGGAVSSIVSYPMLSDINSLAWGADNQEEIVVESIKHAKEAIALDVKDGNSWCKGMGSQQITSVFKTIPKCCMLEIYFEKDESMKSNPNLYFNSATVNTYLENYERALSGFEAAASKNPCLNATEEVQKMVNLFNKLDTLLKASLSNLLLLLLSFEKATGKKPLGIIFYRDVVSDGQLMSRKQLLQYKSGDTADCWCMLSLYDCLLSHMVREWGFELPIGNISYRAMIKYIYFLLATTSGKAVAERFPGKLTAPFEKTKLSAYALAAMVESAILSEELMQGFDQETVVVVVARLTSYKMEMEESFDATRWIDRNLICLCSKFGDYRKDDPSSFSLNPSFSLFPQFMFNLRRSQFVQVKMFNDSPDETAYFRMMLNRESITNATVMIQPSLISYSFNSLPSPALLDVASILADRILLLDSYFSAFAQLLQAPHDDA
The following text describes a protein:
Function:
May be involved in cell wall organization and biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 1750 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MIDINVNNIFFRSYSVDPNSGHAIYVFDSTYLPASDEIGDKQVYDLLINALMDRLVMKLPQAPYSLVIFSSGFSQRKISWVYGIKMFAKLPKETKFYLQKIFIVHESFFVRSVYQVISNAMNFNFLDSKDSQHDFPSLVHVLDLTSLSELIDITRLRISLNVYLYDYQIREHINVPEEYYNRLTPLAIRQYRQLVFDKIFKKLQNDALLCELIFQKPGNYKKVNIFLDIIKRNNYIDLSQWDIYSLASVWLNYFIKNKAKPLIPIELIPLPIVDDLKFTSETFRKIIKFNQYQDLFMVIIPFFNRIIAHGESTKHDSRTLSKALTPALCKEKLSMMTNDRLAIGSRYIKNLLDFFPEIAKEISSPPSSVSSSSTIPVLPKPRKSSPTRYSELGCLTLPRSRSPSPQRSVTSPTYTPVALQNTPVLKPKSSSRNVSSPSFNAKPPLPIKAVTRPQLSLTSNSNTDLALASSSTDTLSSPTKTPSADSLPLSNSSTDLTISDNIKEMVKDEPAKDKNSVETDIFVQQFESLTLVQNAKIKKFDKELQEKKKKNETTSKTADKFSQKGYSDIKASNKVSRLAALYEERLQGLQVMNEMKQRW
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MVKWRAIFLLFLAAATTVCGQEKSDGLALLLNTQSLEAGEEHKPATMYIDVDGGSGAGAIDDFVDHEDGSGLGPDDEDGFSDSEESGSGMPWTDPNEVFPGIVDTIVTAKPVEEVNQPPVEKPTKIKPPKPDPTKPPRPVKTYPPKPPKKEIPVEEKPTKKPVINHISKDPEPTRENNKVEETPQPTSEVLVNRVEQRQNTNNKFTALFSHPGVMAVVTLAVATSGHKLSPWYMAAVIGGAVVGLLCAILLIMFIVYRMKKKDEGSYSLEDHPAKKLNTNAYGKTSKEFYA
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDIDEESYLNAGPSAPSKIPQGGEGDRLQGMSKKAMKRAAKQARLEEIKPLKRAAERERRRQRTAQLAEGYAAGTLSEADKELVERRRRVEKERKEAQRRIESGDQANDWLGGVVIDLGFDDLMTDQEIASMAQQLGYLYSSNRTAEKPVRTVIHTTFSPAASPRLWQRMENFNWHKWSRCHWWEQGLETLKSQLDPSTSILSVQSVVSKETQDKAGIDTKSLLSRLTGPQVPVDLQAGKHKLVYLSADAEDELLSLSEDEIYIIGGIVDRNRHKNLCQGKAEQLGIRTARLPIGTFLEMLPTRKVLTVNQVFDILVKYLHLGDWAAAFEAVIPIRKYAPGRKTKRAKTETKRNEKEEEEVECTSAEGEEDIGVIEESAEVDPEDVFSNQ
The following text describes a protein:
Function:
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
Sequence:
MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYPRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
Sequence:
MKETILVIDDEVKIIEVIKLYLENEGYTVIQATSGIEALEKQSEFNPDLLILDLMLPDISGENVCERIRRESEVPIIMLTAKSSEDSILNGYSIGSDDYITKPFSPKQLVAKVNAVLKRVKGNQRENLIFNNELIIDIVNKKVEYNNKEIILTASEYKILSILAKNPNKIFSREELMDYISRDNTCIYDRIIDTHIKNIRAKLDQDSKNPTYIKTIRGMGYRFNV
The following text describes a protein:
Function:
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 15500 molecules/cell in log phase SD medium.
Subcellular Localization:
[Isoform 1]: Mitochondrion; [Isoform 2]: Mitochondrion. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Predominantly targeted to the nucleus.
Sequence:
MEGFFRIPLKRANLHGMLKAAISKIKANFTAYGAPRINIEDFNIVKEGKAEILFPKKETVFYNPIQQFNRDLSVTCIKAWDNLYGEECGQKRNNKKSKKKRCAETNDDSSKRQKMGNGSPKEAVGNSNRNEPYINILEALSATGLRAIRYAHEIPHVREVIANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYRNKATNNKFHVIDLDPYGTVTPFVDAAIQSIEEGGLMLVTCTDLSVLAGNGYPEKCFALYGGANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLSIDFYVRVFVKVKTSPIEVKNVMSSTMTTYHCSRCGSYHNQPLGRISQREGRNNKTFTKYSVAQGPPVDTKCKFCEGTYHLAGPMYAGPLHNKEFIEEVLRINKEEHRDQDDTYGTRKRIEGMLSLAKNELSDSPFYFSPNHIASVIKLQVPPLKKVVAGLGSLGFECSLTHAQPSSLKTNAPWDAIWYVMQKCDDEKKDLSKMNPNTTGYKILSAMPGWLSGTVKSEYDSKLSFAPNEQSGNIEKLRKLKIVRYQENPTKNWGPKARPNTS
The following text describes a protein:
Function:
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
Subcellular Localization:
Endosome.
Sequence:
MFHGIPPTPGMGAPGNKPELYEEVKLYKNAREREKYDNMAELFAVVKTMQALEKAYIKDCVTPNEYTAACSRLLVQYKAAFRQVQGAEISSIDEFCRKFRLDCPLAMERIKEDRPITIKDDKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMSASDELDDSQVRQMLFDLESAYNAFNRFLHA
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKETHENHLRTHNGIFPVSLLSTQARQLLNFKLKSPSYYLLNSFKLLVKSEGNNQSTTADVTLTKSPNAYHASSAREEKDLQVSRRDTCFYCSRKIIKCICNEEHVGIESVQLKLILLLCQNLPNVTTNAKKYFSSLADGHNFTLTLYKFSLDNQTFSQLLSRFKSFATLTELLQVHNVMLQVNFSFQARQLNTEIQLRRCHSLEKTWKFLFGDYELPDVLKDMESSNSDWSDTSLKRIAYLCSLVEELKLHSSIMNDKYVCLVSKHNNALEDKFNSEAARQLLQKSLSIVASNLKQAENKTISYEEKLSIAQNSINEIQTQNRDLKLETEKLQDQIKALLERNQSLQEALETVKNDEKNLREMNANYETEMKEARQKLNNKEALISHYDDDFRAKELKISRLSESLREKAGLLEFQSSVSEQRDLLYQEQIQSSIKDMENVFRKNEYLMEELNELKNNLEVESSKVLRLDEEMKCLKDEQLSQFDTVFSLTDERDGLQKDLKNTKGNLDDEIGRSAFLKSQIRDQELTIEKLHDSLETLSQTNNSLQCEISEKNAELNSVNSKLSEGRAHLETANKENEILKQQLELSESKLASLLNSYQSFINKKEHLYSFLQLVEPSFAKSDSSNATESQISESVRKGISIFNLLFIVYKNVCSQAGINPSTKLEDLDEHTLSDELTYITKKFVQKDQEYQTKEIELRNYKITLQSLLEDKLIGVNTDCRSPSCSDFEQLGQESENNTSISGRVSKLVKSFNDSSSISNNTKISITKSPSGEKVSVFKEMSDIALRDMDKNRKLLGENVDVRNIVVQKDESLNIDLQNNAVVPELHFKEGMVYDSLENAYTYLAESKRMLANELQMKQEDLEKVILELEAYKEIFLEEKQIPCEEFMPGKNAKSEKSLRSVFQEQLMRETKRVRKLEKVNSELKLHCFELSERLREREHTLQQTFGDK
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. uS12m is required for respiratory growth.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLSRFMSNTWCTPLRQAQRLFSSTTTMQATLNQIKRGSGPPRRKKISTAPQLDQCPQRKGVVLRVMVLKPKKPNSAQRKACRVRLTNGNVVSAYIPGEGHDAQEHSIVYVRGGRCQDLPGVKYHVIRGAGDLSGVVNRISSRSKYGAKKPSKS
The following text describes a protein:
Function:
Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress; [Isoform b]: Acts as a negative regulator of myosin-dependent contractility of smooth muscle-like cells in the somatic gonad.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, I band. Note=Absent from the distal edges of the thin filament. Isoform b: Partially overlaps with the region where myo-3 is located.
Domain:
Calponin-like repeats 1-3 are required for actin binding and acting bundling activity.
Sequence:
MLSFNNTTSASSFQSASSRYLMSSSSSIGPPQQQSAKLFPEHFYPSGLSPRQSEALERLRPNTASRERNIPIQFTGKNPTTNSALEEYKPVPHVQVTSPKSSIVPNFVSEQRGLQPQPTSQAPTNYRQFVAAPRSPRGYGDYPEMTGKASAAGDSEPVQIPIKTQTPITQARAQETKIPTIVSPHPVYYYDNQEQPIQQIREEQPNATMETKVTGQGQPKRVGRWTLAQLRQTDGIIPSQAGWNKGDSQKLMTNFGTPRNTNTRVKSENLQEIPEDIANRTHGEVRLQSGTNKYCSQRGMTGFGSGRDVCREGVRVAQNPADLAELPEEKIRMSEGIVRLQAGTNKYDSQKGMTGFGTGRRETTKMVDSKHPEYDHEKPDQSEIPLQSGTNKFASQKGMTGFGTARRETTKMVDSNHPDYSHECSIDQTTIPSQMGSNQYASQKGMTGFGQPRWEVLDPSISWQNRKSQGMVRLQSGTNRFASQAGMIGFGTCRNTTFEAEGGELPYEAMKVSETIIPSQAGWNKGDSQKKMTSFGAPRDVKGKHLKRIWELEYPEEAEISLDRL
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGSDFILVVDSSVEEQVEELAMYLDNLEANTDKNVLALCREYLASENVKEVLNLFLTRLPLLAQAPEKELEPILAVFINLIQESAAFEDHVSKFCQALEQIADQNNNLTPAILSVLSILFNTAVKERQHARLSILTSVVTLTTRYSLFSTLAPNLKYFPDWLKEAGVSVSDHRAFNIFVSKAIQSYDDEQSFAFLLEAVKMDNSTADEAVRELVQRAVNSPKYFFFDDIVTLPPVQQLEQSTLQLLGILSGGMTDDYVSWVAENHAHCQHQKFDEDAIARKMKLLTIASLATQAPNNTLSYGDVAKSLKIDENEVELWIIDVIRAGLVEGRMSQLTKTLSIHRSSYRVFGKHEWVALHEKLAKWGSSLRYMLQVMEQPLSSFTIASSKKGNRDGSAVTASE
The following text describes a protein:
Function:
Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Nucleus. Mitochondrion intermembrane space.
Sequence:
MAQEQCLFEGSDDLDISHHCQDVEEKYFAQVVGHIEDILLDDSFLKIHKDFMEEYWTEFEESDENKLIYTDIFKKYVETIEKFLETELKKKIPNFSMLEFEYELRKRPNELVGEVFEILSTFTDFVSFKEKFLDYKAVCSHCLLLKPF
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. May play a role in midgut regionalization.
Subcellular Localization:
Nucleus.
Sequence:
NNNNNINNNNSRLNIATSSSATPSTTFQQKSPYYDTTTSTTVTSLTSTDYSSYQQQQQLLLAEFDTDYKENAEQFADVSVQNVNISCSNSNNNNTDLNNNSSKCMNNSNIIIDNNSTDSFQQKQHPETTEDTKYNAETEEDRKSHGKAFGGHFASSRYGIDDDVISNRTGSRPSSPASTTPSCENFSPHSPSMKGGKMGSAPSYPWMSIVGPNSNQRRRGRQTYTRYQTLELEKEFKFNRYLTRRRRIELSHTLYLTERQIKIWFQNRRMKEKKEVQAIRELNEIEKTKIGCFGSLRSPCDDDDDDDDDIDGSGSSGVCGVASGGIGGGDCRKVSGNSGSSRNGLSSNGGNVMGGINGAGGGANVVNHDELITSCRDVPSQQNCLNGNNNNNNNINNNNINNNNGVEMMVGMVCSSGRMMMEGVDYGGG
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MGIKILLILGLLTLAVVAESANATWTLTKSCVNGQGCIGEDGELDYLMDSETNRRQLAARRSYISYGALRKNNVPCSRRGRSYYDCKKRKRANPYRRGCSVITHCYRQTS
The following text describes a protein:
Function:
Negative regulator of photomorphogenesis modulating both light and abscisic acid (ABA) signaling pathways. Negatively regulates the light-mediated inhibition of hypocotyl elongation, probably in a PHYB-mediated signaling pathway, but promotes flowering time (especially in long days) and lateral root formation. Enhances light-regulated gene expression. Promotes COP1-mediated degradation of HY5 during seedling development (e.g. hypocotyl growth) through enhanced ubiquitination in the darkness. Also involved in root gravitropism.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein. Note=Constitutively localized in the nucleus of hypocotyl cells.
Sequence:
MAAATTTLSSSSSSPSLTLINASHRFVSVTPFSSNSIFLRRRFRRLNRSLASSSSHSRRRYESDDRFFGGGDNYDVVPDDDGFSDDDDEEDERESSVDLLIRFLRSMFKKVSKRTKKASRRILPAAMSPRLVSFAVDGILLLGSLSITRAFLEVICNLGGTVFTVILLIRLFWAAASFFQTYGNSFGPNPVN
The following text describes a protein:
Function:
May be involved in vacuolar sorting and osmoregulation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MPVPLTAEEAGKRGFSEIETFKHVRALTQLGPHPVGSEALQYVLTACENIKKTALWEVDVMDIFHAKFGANHMHCGLFSGRTLVYSNLNSVLVRILPKYVSEEGSVMLELARGISQWPDGLERAVIFLFNTGEEEGLNGAHSFITQHPWSKTIRVAIDLEAMGIGGKSIIFQNDKLELLKTRSLQHLGGNMFAFLFHIGASSHIPEGNSTQSEEDISKNNAIYFDILFANMLHNSVIMQSLIIWVTSLVMGGIPAAASLALSCLSVLLM
The following text describes a protein:
Function:
Involved in the fucosylation of N-glycans. Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the distal GlcNAc residue in N-glycans. Catalyzes the transfer of fucose to Gal-beta-1-4-GlcNAc-alpha-pNP (LN-pNP) and Gal-beta-1-4-GlcNAc-beta-1-3-Gal-beta-1-4-Glc (LNnT). Unlike alpha-(1,3)-fucosyltransferase fut-1, does not transfer fucose to Man-alpha-1-3-(Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4-GlcNAc-beta-1-Asn (M3), Man-alpha-1-3-(Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4-(Fuc-alpha-1-6)-GlcNAc-beta-1-Asn (M3F6) and GlcNAc-beta-1-2-Man-alpha-1-3-(GlcNAc-beta-1-2-Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4(Fuc-alpha-1-6)-GlcNAc-beta-1-Asn (GnM3F6).
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MSQIGGATCTWRYLGRFVTLGIYASVALFVWYTLVPTRSKHKDSIAINNNNADPATALIPVHTKNVVIYAATKFFGHPITTERFLATCPDVQNYCRITQEESEFDNADAVLFHNADYRGSTDKFKKMKSQRKPGVPYVLWSLESPTNDMFRPDSHMINWTMTYRTDSDVWAPYGTIVKLKNPVEVDLNAIWEGKTKTATWLASNCITQNHRFDLIKKIIDNGFEIDIWGNCGKQVSQCAGVDNQESPCVLELIKPYKFYISMENSNCKDYVTEKFWKALNDRMTIPIVLARKYYKDLGVPDSAYIAVDDYATLDEFLAHVKKVNKEKDLFLSYHQWRKEWKVIIGSGFSGWCTLCNKLQDKDYILKNPKSYKDVAWWHSFEMCNNQIASKYL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
Sequence:
MFSSSSSGAGSSSGGGSGSGSGFPMQPNLPGSHQPRCAICLHAVYMPFRMPCGHINCFNCQKNVGTRCTLCRQEFNVGLFNYTQQINLKEAVHPNYVDAQPDSDGRVFVQDMVYERDEDVKPSVEELKAAMAAAAVAAQPVTTEGKEVAPPKMPYFHDRNSKVFWLYQSRSVKEKKEAWWRFNGRMELDIEEAFQRRDDGYMVYIDGQNYSIDFDEMIQFRMSNPAVSRKIKRVNSDEFDQLHVLGIGGVMAKTGEWEVK