lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MAQKAKIQRVTGSEHVLLRPDMYVGSVSAAETFLWLYEPGQGLYYTKANIVPGLCKIFDEIIVNASDNKQRDSDRSAEHKMTYIKCSVDVASGAISVENDGVEGLLHFDEKEKMYLPTLAFGILMTSSNYDDTEQRVTGGRNGYGAKLTNIFSTKFTVLLQENGQVFEQTWTDNMKNTKPPRIEDVRDKKKNFIRFSFTPDYMKFGMTSGLDRDHAAYMMRRAVDVAGCNIGLKLIINGTELKIANFEQYARMVYRSINPEITQFYETSKGDTAQVNTNDSDSDLDIKSAAKAKPKTKRTKKTIETNSLLIPVDDLSKPSDWTHDYLKVIPVNKFWDIGLGYTDSGELVQVSFVNSINTTDGGTHVDAILDLIMSQLNDVLIKSFQQDAKNAKKLTRQQLKSCLVLFIRSLVVNPSFDSQTKISLKTDKAALLRSLGSTQAELATLATQLVKRIQEIRPLWNSLRQASYNQAAKLLTKTDGSKTSQLLGIPKLDDAIAAGTRESSKCTLILTEGDSAKALAVDGISSIEDGKKYYGVFPLRGKVINVRNESIDKVSNNAEITNLKKILGLKQGMDYSTQEARNTLRYGHVMIMTDQDPDGSHIKGLLINLFDTYWNGLARSNKFLDFFITPIVRCTQARNMKTFYTIPEYKKWTQTVTDLPKWNINYYKGLGSSNTTDAKQYFQQIANNRKTLIYNPESASKLKLAFDKKLADDRKTWISGTDPDTYLDLSPTKIDITAFVDKELVLYDIESNQRAIPSLMDGLKPGQRKVLYACFKRNLKTKLKVSQLSGFVSDKAAYHHGEASLNGTIVNMAQSFTGSNNIALLYPAGIFGSRARGGKDSSAPRYISTYLDPLARYLFPEPDDAIMQYKEDDGKVIEPFYYAPILPMVLINGSDGIGTGFSTTIPQFDPLDMLHSIRLRIYGKTTRREKRTLKPFSNGWKGTMTHEYDKSGKFVRWRMTGCFSVVDLKTIQITDLPIGVWTESYREEIETWVKGNEDAGTAKKPATKVSATTKGKAKLKGASGAAKEKPAAKDQLYDSVTGYYKGIHPALMKVIDMSDNNTVNIIVTLSDECARYLIGTSDVDIETCNTAGTARYDNIVKGFKLDGSIRPSNMWLYNERNMLCLYHTPFKIIDAFYAKRLDLYRVRRNNQIIDMDDRSLMLNEKARFIKLIIEDKLNIKNVPRDSVTELLWGKYQFHPSRKHRIILLSHRNLINKRQALKIDEDSERPEEDDDADQRDLEKHLEATVKDLIGPQFFDAINSWSGFTVQDRNECYEYLLRMPISTMTKESYRNLLSSAELIRAEAEKLRNTTVENMWLRDLAAFEAAYEVDRHMEQTKSAETRRLTVTETMIQGKLEESERKYKAMDDRVGDSDNEIEYSTTRDDQGLKIKGEPKPKKEHVPKTAPASKAKVQKPEEGLETAPTEPKRKRPAAAPVDTKKASAKRGKKEESSFTESETSATELDSSVLEDDYSYVSYTYDEDDENGEDDL
The following text describes a protein:
Function:
Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.
Miscellaneous:
MISCELLANEOUS: Present with 1130 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud neck. Bud tip. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MTSASITNTGNETMNLPQMRSIWLDEDEEAEKLYGLQAQQFMGSDDEENLGITFINSDKPVLSNKKNIELPPLSPNSHPSCHHRRSNSNSAKSKESSSSSSSANKTNHKKVFLKLNLLKKKLLGAQPDIRGKGISTPFDFQHISHADTRNGFQDEQLQEPSSLSTEIKDDYTSSSSKRDSKSLNKAFVTERIPANRESKLISRSHENKTSRLSVARSISVTSSNYSKNTQGNNHSINGRVVSTSTMATSIFEYSPNASPKQFKNKSHALGHRYTNSTDSSESSLDFLKNYNFPTLLEDKPILDFLPRSQRSSAYRSLLETPNSNKDSAKAFFPSRQSPLPKRRNSIATPSPQSKFSYSDSPVNHRKSFDDVLYSFNQLEPLQT
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MDLIKYFTFSMIIFILGIWGILLNRRNILIMLMSIELMLLAVNLNFLVFSVSLDDMMGQVFALLVLTVAAAESAIGLAIFVITFRVRGTIAVEFINSIQG
The following text describes a protein:
Function:
Member of the two-component regulatory system PhoP/PhoQ that plays a role in the regulation of resistance towards polymyxin B and cationic antimicrobial peptides in response to limiting concentrations of Mg(2+). May function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals leading to activation of specific gene promoters (Probable).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MIRSLRIRLMLGAAALAVLFMLALLPALQRAFGIALENTIEQRLAADVATLVSAARVEKGRLVMPEHLPVEEFNLPEAKVLGYIYDQNGDLLWRSTSAADESINYTPRYDGRGNEFHTTRDAKGEEFFVFDVEIDLLRGKQAAYSIVTMQSVSEFESLLKGFREQLYLWLGGALLVLLGLLWLGLTWGFRAMRGLSSELDQIESGERESLSEEHPRELLRLTHSLNRLLRSEHKQRERYRHSLGDLAHSLKTPLAVLQGVGDQLAEEPGNREQVRVLQGQIERMSQQIGYQLQRASLRKSGLVRHREQLAPLVETLCDALDKVYRDKRVSLQRDFSPSFSVPVERGALLELLGNLLENAYRLCLGRVRVGARLGPGYSELWVEDDGPGVPAEQRARIIRRGERADTQHPGQGIGLAVALDIIESYDGELSLDDSELGGACFRIRFATV
The following text describes a protein:
Function:
Controls cell polarity, through the G1 phase of mitosis, via regulation of for3 localization. Required for actin cable formation where it directs the spatial distribution of the actin cables.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Localizes at the cell cortex of the 'old' growing cell tips.
Sequence:
MAIYSSFWIRLYFTFRFFCYFLTSVVASDVSFLGDFSGFNVLSNSSANTDLSSQFFEQTNNGSLSSLIDTSYSNSQICYSSWQGDLYVIVLDSEQQTVLLQSNFTSNPTSLEIFSSQNTSFFGNISAIFCDDKFPYAYATFTFSDKPSFTSIYRWNVTNSNVTIEHFYNVKGNVDSLFFLNNDSVAISGNFTEISPFSSSNGPQIAKLAFRSNNSFSQNSLNRNLSSVSCDLTDSYSLWDPSSSGLVSIYAWAPYLIDFNRIRFYNYESSENSVAFFSAINPADGTVLPLTHYDLETGLSSTCDVNCSLQNFANYQDFYFSKGYNSYQIEIQMFGNGEATENSAFGLSSLQFFETNQNSYFDDSYNQESCGFPGLNSLSSYEGNFEASFSNASMPYWIQTIAGEQASVSFFPNITVPTNGTVQLLIPGCTYDNTCSQRGSVIANVYFAKNKQPATKLVQQASDFDQYVSLYSGYLQGFSDNFRPYVELLPYKNSRMVTHSIRFLEQSYTNVSNGLVFVNTTTDVNKLPSIIEFPAASKLRGTAISQIKSLSNGNFSLYMTGNFSDNYGNNVVYMDSLNHLHSFPNNGLNGWVSYIYVSGDSSYFGGNFTHTGDGSIKLNYIAMYSETSRNWSSLGLGTNGPVTHIGSTSLFIDGKIESFISFQGDFNEVYTSEGYAISTSGFSLWNPSSKSWVSMEKLGFYMSGYLFDIPGFNSTQRIYSGNLSAIASYSTRNIAHFSSDSLNDTFIPCYVNAFPSYIRLEDIAYPFANNSMIAILGSEEMEDKCTAAVYFANSTEPIYPKRILSANCSSKFIVLEDCLIIYSNDTDESDIVKNTFVSFNTTSNSLGNTTALSQLKGHINSVIVDDSYNNIFFGGNLSEQSSGCVGFCIFEYNSSSWRNISHNLISAEVQSILWVNETYSSMYLAGKFVWDTSDVDYLLMYNFDNNTIMSCKGSSSIPGPVLLASLKSQSKDEYSVLLYGTEVSSSDTYLNVLNSEGAINSYSLDIHLNQSTINSIDFFESNQISQIPINDSIIVLSGLIVLDDSSKASAVYCVNKSCLPLLTAFKDNGEAGIVRKVVQQKSFSSSASKMIPVTTKYDHIGQPRYVVIISLGISIGVMFLIMSGSIVVEIIHWFFSEHVETLHDYSNFLKELKTQ
The following text describes a protein:
Function:
Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLFNKGLLALAATAALGVSAQDAVAPADSAVVKLEQDNFQDFLKENSLVMAEFFAPWCGHCKKLAPEYVKAAEELKSKNVSLVQIDCDDNRDLCMQLQIPGFPSIKLIKDGDIAHAKDYNGARTAEAIVKFMIKQTQPAVQVVEDKAALDALVANSTVPVVVDFGVNDFNATFYQFAHALSDDYVFISLPSKENKISVFLPVEGSSAEEIVFKGDHKTLAKDRSVFEEWLKVESLPFFGEINGEVFNAYLESGLPLAYFFFNEPSEVEENRKFFTDLAKKYRGKMAFVSLDAKQFGRHAENLNMKQQFPLFAIHNMTSNQKFGLPQMAEEEFAKLNKAIKLKTKDITKLVENVLSGKAEAIVKSEEVPSVQESNVFKIVGKTHDKIVADPKKDVLVKYYAPWCGHCKKMAPTYEELADTYASDSSSKDKVVIAEVDATANDIFNVEIAGYPTILLYPAGKNAEPVVYEGDRSLDSFLTFIKENGANGIDGSSLHKKFLETKKAAEQAEIEDDNEDEDGFDDEL
The following text describes a protein:
Function:
Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
Sequence:
MGQKVNSNGLRFGINKNWISRWTASSNQQTATWLVQDEKIRNLFFINYRNAQVSNVEIERTQTTVDVYVYAAQPALLIGSENKNIQKITKMIQIIVGRKIKLDLTINEIGSPMLSSRIIARDIANAIENRVPLRSAMRQALTKVLKAGANGIKVLVSGRLNGAEIARDKMYIEGNMPLSTLRADIDYAFEKAKTTYGIIGVKVWINRGMIYAKGLNRTPAHILHPQKKQLKTPTIKKTNSVIAKQKLTGSDIETASLKALTDNNQNHE
The following text describes a protein:
Function:
Catalyzes the hydrolytic C-C cleavage of phloretin to phloroglucinol and 3-(4-hydroxyphenyl)propionic acid during flavonoid degradation. Also hydrolyzes other C-acylated phenols.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEDFNMSTPGVKVGVXEEEKKLSYYKYYEQDLAPVPAEKIAILQGGPIAPEKCIPFDERNKFLKGEDDEYANIGFGVAADGTALVCNTTYMPGVTGEMLDWWFPWHSVGSDLRYKIWDPEDHYFARAYPASYVVDPNVPMNQKTWGVDHYIMEDVGPGPEFLKLCFKRPADFGYDESIIGTEKCESLVCAIGESSCAAAMTHKWHPYKDGVLFESRFWIGYRIDEEGNIVKAIPEGVSIPPFVPQGLFAHNIKEFTNLAAILPTLYAEEKDTF
The following text describes a protein:
Function:
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
Sequence:
MIARPTNPMVSSLLNEMYHVTTAYAYWKAGKHLDRAVFDLCHCKPPFGGEFTVFAGLEECLRFVANFGFEDCGIDYLRSVMPSYVEDEFFGSLKALDCSQVIIHAIPEGTVVFPRVPLIRIEGPLWVVQLLETTFLALVNYASLVATNAARYRLVAGSSKVLLEFGLRRAQGPDGSISASKYCYLGGFDFTSNLEAGRLFGIPVGGTHSHAFVSSFMGLDEIALSRTSENTKFCKDFGARIQHWLSKLKAKFYSFFSAVESLHVKETNESELAAFGSYALAFPEGFLALVDTYDVMKSGVPNFCAVALALHSLGYKARGIRLDSGDLSYLSKQARAFFRSADEINGFGIGTQLVTCYKQPALGCIYKLVEVNGHSRIKISEDVAKVTIPCKKQCYRLYGEQGFALVDLMQKDEEPAPQADEPVLCRHPFNLNKVYVVPKRVEPLLQCYWKGSLGKLEKIHQKELPSLKETREYCRQQLAAMRPDHMRIRSPTSYKVSVSAQLYDDFHTALFNEGPVKELR
The following text describes a protein:
Function:
High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM. Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues. Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways.
Miscellaneous:
MISCELLANEOUS: Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells; MISCELLANEOUS: 'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Early endosome membrane; Single-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Note=Continuously recycles between cytoplasmic pool and the plasma membrane to bind as much IgM as possible; [Isoform 3]: Secreted. Note=Detected in the serum.
Domain:
The Ig-like V-set domain comprises three loops analogous to the complementarity-determining regions (CDR) of Ig variable domains, which are responsible for engaging IgM. Mediates multivalent interactions with the CH4 domains of pentameric IgM, facilitating receptor clustering and signaling.
Sequence:
MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA
The following text describes a protein:
Function:
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis. Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription. The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival. Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm. Nucleus. Note=Glucose deprivation results in its AMPK-dependent phosphorylation and subsequent nuclear translocation. Phosphorylation at Ser-659, leads to exposure of its nuclear localization signal which is required for its interaction with KPNA1 and subsequent translocation to the nucleus. Found in the cytoplasm in undifferentiated neurons and upon differentiation, translocates to nucleus (By similarity).
Sequence:
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a/ATP6 in the membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=The F-type ATP synthase complex is anchored in the mitochondrial inner membrane via the F(0) domain with the F(1) domain and the peripheral stalk extending into the mitochondrial matrix.
Sequence:
MPQLVPFYFTNQIFYGFASLSVIVYLFSIYILPHYLEIYVTRIFITKT
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MANVLVAMSGGVDSSLAAALLLEAGHQVTGVTMHLWDDDEQGLRESLCCAAEAAASARRVCALLGIPFYVFNYQREFRRHVIDYFIRAYTHGLTPNPCVECNRMIKFRALLDRARTLGFDAVATGHYARIIQGEDGRYQLWRAVDLEKDQSYMLHMLGQAELSRLIFPIGAYTKREVREMAAARGLPSADREESQDICFVPDGDYRNLLRIESPESLVPGPIVDLEGREIGRHRGLPLYTVGQRRGLGLGGGEPRYVVAIDPARNALIVGPAAALNRARFTVIDACWVDDAPPAESFTCLVQVRAHAEPLPARVSQQPDGRWLVELERPQRAVSPGQAAVFYRGQQVLGGGWIARPEVA
The following text describes a protein:
Function:
Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response (By similarity). In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream (By similarity). In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients (By similarity).
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MASLGLQLVGYVLGLLGLLGTVIAMLLPSWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTMLGLPADIQAAQAMMVTSSAMSSLACIVSVVGMRCTVFFQESRAKDRVAVVGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIFLCFSCSPQGNRSNYYDAYQAQPLATRSSPRPGQAPKGKSEFNSYSLTGYV
The following text describes a protein:
Function:
GTPase-activating protein (GAP) that stimulates specifically the intrinsic GTPase activity of Ypt/Rab-type GTPases YPT1 and YPT7. Functions on the Golgi as a negative regulator of YPT1. Functions on the vacuole as a negative regulator of YPT7. It is also active on SEC4 and YPT51. Provides a catalytic arginine (arginine finger) and glutamine (glutamine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable).
Miscellaneous:
MISCELLANEOUS: Present with 206 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, Golgi stack.
Sequence:
MGVRSAAKEMHERDHNSDSSSLVTSLMKSWRISSASSSKKPSLYKMNTTESTSLPSGYASSADRDRRTSDGNFEAMAKQQASTRRTSNSYSPLRYVNPTLSTASNESPRPALLLRQHHQRHHHHQQPRHSSSGSVGNNCSNSTEPNKKGDRYFKDLDEDWSAVIDDYNMPIPILTNGGFGTPVAPTRTLSRKSTSSSINSISNMGTSAVRNSSSSFTYPQLPQLQKEKTNDSKKTQLEIENERDVQELNSIIQRISKFDNILKDKTIINQQDLRQISWNGIPKIHRPVVWKLLIGYLPVNTKRQEGFLQRKRKEYRDSLKHTFSDQHSRDIPTWHQIEIDIPRTNPHIPLYQFKSVQNSLQRILYLWAIRHPASGYVQGINDLVTPFFETFLTEYLPPSQIDDVEIKDPSTYMVDEQITDLEADTFWCLTKLLEQITDNYIHGQPGILRQVKNLSQLVKRIDADLYNHFQNEHVEFIQFAFRWMNCLLMREFQMGTVIRMWDTYLSETSQEVTSSYSMSSNDIKPPVTPTEPRVASFVTPTKDFQSPTTALSNMTPNNAVEDSGKMRQSSLNEFHVFVCAAFLIKWSDQLMEMDFQETITFLQNPPTKDWTETDIEMLLSEAFIWQSLYKDATSHWL
The following text describes a protein:
Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (By similarity). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRKDERERDTPAMRSPPPPPPPATATAASPPESLRNGYVKSCVSPLRQDPPRSFFFHLCRFCNVEPPAASLRAGARLSLAALAAFVLAALLGAGPERWAAAATGLRTLLSACSLSLSPLFSIACAFFFLTCFLTRAQRGPDRGAGSWWLLALPACCYLGDFAAWQWWSWLRGEPAAAAAGRLCLVLSCVGLLTLAPRVRLRHGVLVLLFAGLVWWVSFSGLGALPPALRPLLSCLVGGAGCLLALGLDHFFHVRGASPPPRSASTADEKVPVIRPRRRSSCVSLGESAAGYYGSGKMFRRPSLPCISREQMILWDWDLKQWCKPHYQNSGGGNGVDLSVLNEARNMVSDLLIDPSLPPQVISSLRSISSLMGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKGDRKLHKGLSSKPSFPTAQLRRSSGASGLLTSEHHSRWDRSGGKRPYQELSVSSHGCHLNGPFSSNLMTIPKQRSSSVSLTHHAGLRRAGALPSPSLLNSSSHVPVSAGCLTNRSPVGFLDTSDFLTKPSVTLHRSLGSVSSAADFHQYLRNSDSSLCSSCGHQILKYVSTCEPDGTDHHNEKSGEEDSTVFSKERLNIVETQEEETVKEDCRELFLEGDDHLMEEAQQPNIDQEVLLDPMLVEDYDSLIEKMSNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATDVLHAVWYLTTRPIPGLQQLHNNHETETKADSDARLSSGQIAYLSSKSCCIPDKSYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSENDRLLVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIEAEEGDDTESDDDDDDDDDDDDDDDEELDSDDEETEDNLNPKPQRRKGRRRIFCQLMHHLTENHKIWKEIIEEEEKCKAEGNKLQVDNASLPQADEIQVIEEADEEEEQMFE
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAYASTIQIRDVWAENLESEFELIRSLIDNFTFISMDTEFPGIVFKPENGSSHKNLPPKANYSLLKQNVDALKIIQVGLTLSDSEGNMPDLGNPKYRYIWQFNFCDFNVAKDQQAADSIELLRNSGIDFDKNLKLGVKSVKFAELMMSSGLVCSDIEVTWVTFHCTYDFAYLLKVLTQLPLPSELSKFKDMVEIFFGERVFDVKFMIMFLDGLYGGLNTVAKSLLLERIVGQSHTAGSDSLLTWMVFQRLRDLYFNTPDRIAKYAGKLYGLESS
The following text describes a protein:
Function:
Transcriptional transactivator that is necessary and sufficient for reactivation of the virus from latency. Acts post-transcriptionally and transcriptionally to regulate viral lytic gene expression and synergistically with ORF57 activates certain early and late viral promoters including its own promoter. Autostimulation on its promoter is mediated by the formation of a ternary complex between ORF50 and the cellular components HGMB1 and POU2F1. Also possesses a bimodal activity in targeting proteins for degradation through using its own E3 ligase activity or by stabilizing and chaperoning host E3 ligases. These activities help to subvert the host innate and adaptive immune responses while also modulating the host transcriptome and protein landscape to promote virus production. For instance, targets the host SMC5/6 complex for ubiquitination and subsequent degradation through the ubiquitin-proteasome during reactivation while during latency, host SMC5/6 complex binds to the viral episome and condenses viral chromatin, creating a repressive chromatin structure to silence genome transcription. Hijacks the cellular E3 ligase complex RNF20/40 to increase the level of transcriptionally active RNA polymerase II on viral gene promoters thereby facilitating lytic gene expression. Acts as a SUMO-targeting ubiquitin ligase and affects general sumoylation of cellular proteins. Promotes the polyubiquitination and subsequent degradation of host MYD88 and thereby inhibits MYD88-mediated TLR4 signaling. Induces the degradation of vFLIP/ORF71 together with cellular ubiquitin ligase ITCH to prevent vFLIP-induced NF-kappa-B signaling.
Subcellular Localization:
Host nucleus.
Sequence:
MAQDDKGKKLRRSCVESFVGLSDELKAQLYQCVLLINDAYETIYDPSDLNRVVEDVCIRIMKECSKLGALCGLFTDINMFNLFCFFRASRMRTKGAAGYNVPCAEASQGIIRILTERILFCTEKAFLTAACSGVSLPPAICKLLHEIYTEMKAKCLGAWRRLVCNRRPIMILTSSLLKLYNTYDTAGLLSEQSRALCLLVFQPVYLPRIMAPLEIMTKGQLAPENFYSITGSAEKRRPITTGKVTGLSYPGSGLMPESLILPILEPGLLPASMVDLSDVLAKPAVILSAPALSQFVISKPHPNMPHTVSIIPFNPSGTDPAFISTWQAASQNMVYNTSTAPLKPATGSSQTVSVKAVAQGAVITATTVPQAMPARGTGGELPVMSASTPARDQVAACFVAENTGDSPDNPSSFLTSCHPCDPNTVIVAQQFQPPQCVTLLQVTCAPSSTPPPDSTVRAPVVQLPTVVPLPASAFLPALAQPEASGEELPGGHDGDQGVPCRDSTAAATAAEATTPKRKQRSKERSSKKRKALTVPEADTTPSTTTPGTSLGSITTPQDVHATDVATSEGPSEAQPPLLSLPPPLDVDQSLFALLDEAGPETWDVGSPLSPTDDALLSSILQGLYQLDTPPPLRSPSPASFGPESPADIPSPSGGEYTQLQPVRATSATPANEVQESGTLYQLHQWRNYFRD
The following text describes a protein:
Function:
Involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics. Catalyzes the SAM-dependent deamination of dTDP-4-amino-4,6-deoxyglucose (dTDP-viosamine) to yield dTDP-3-keto-4,6-deoxyglucose. It can also catalyze the oxidative dehydrogenation of the non-physiological substrate dTDP-D-quinovose to dTDP-3-keto-6-deoxy-d-glucose. It can also deaminate dTDP-3-amino-3,6-deoxyglucose.
Miscellaneous:
MISCELLANEOUS: The reaction starts by the transfer of an electron from the [4Fe-4S] cluster to S-adenosyl-L-methionine, spliting it into methionine and the radical 5-deoxyadenosin-5'-yl, which attacks the sugar substrate.
Sequence:
MTAPALSATAPAERCAHPGADLGAAVHAVGQTLAAGGLVPPDEAGTTARHLVRLAVRYGNSPFTPLEEARHDLGVDRDAFRRLLALFGQVPELRTAVETGPAGAYWKNTLLPLEQRGVFDAALARKPVFPYSVGLYPGPTCMFRCHFCVRVTGARYDPSALDAGNAMFRSVIDEIPAGNPSAMYFSGGLEPLTNPGLGSLAAHATDHGLRPTVYTNSFALTERTLERQPGLWGLHAIRTSLYGLNDEEYEQTTGKKAAFRRVRENLRRFQQLRAERESPINLGFAYIVLPGRASRLLDLVDFIADLNDAGQGRTIDFVNIREDYSGRDDGKLPQEERAELQEALNAFEERVRERTPGLHIDYGYALNSLRTGADAELLRIKPATMRPTAHPQVAVQVDLLGDVYLYREAGFPDLDGATRYIAGRVTPDTSLTEVVRDFVERGGEVAAVDGDEYFMDGFDQVVTARLNQLERDAADGWEEARGFLR