lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability. Required for efficient primary cilium formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MVIVWQQPYVNVFKHFDVFNLKRASKEGDALVTMDKTLRSSVFKIIGSIPASNYLQIPKTSSQSLGLIGRYLYLLFRPIPSKYFVVHMDVATDDGLIVRISFSNLFREFKSTSTWLQFPFIVKPANDQPDTAPSATRWTVLLLDMSYVLSAYLNYKYAYLKSIRLCANMYVKGIFTSDMEYEPGTFSTSRRKTAVAGIEPLPREMTFPIAKGRDWYDVYDCIKFPVDTHRNKTDWQSMMTDNTKERKLRRIAYFVNKIPDNPLKLGTPPRTKVPSKLPKAGTADGPVGACPDNNGEVHVYAYPKQQIVIHEHDKKTGRKLKPDPILNLKRIIGFGGSTSEALWTCDGSHVLYACNAVIVAMEVSSGDQRLFIGHTDKISSLSFNGNSTVFASSQTGQLPVIRIWDFYRGDCLAMFKSHVHSVYLLSFSFSGDTLCGVGKDNHGKQLVIVWNTSDAQKSGEVTVIAKAHTDANISKMKISAFDSTRLVSCGLENIRFWRIREQSLRSCPVNLKDYHNEEFTDIVFADEFNVSQNVPDRRLFASSASGRIYEIHYGRICIDHVYTLTSVGPDSKSSVSSINTIRPGISFFAIGTDDGYLRLWAFDFKTILLEAEHEGPIAAIDVTKDGSRILVTTKAGNVGYLEYSTRNYVTIMRSHLDQVVAASIDSHRRHLVTASRDETIRIWDIDTYAQLFDFKAPGEVPCAICYHPSQQCFACGFTNGTVRTFHVGTSSLLAEHSKNHPGRIIGLAFSPSGRFMYSAGTLGAIALYDATSQTYDLLRLLPYTIARGDIYGPDAISVSSDSKRIVFVGPTEFTVTIMDARSLDEVLKIDIGNAVTAAAGSTTTDRAVKVHFAPAKTNELLVITSSCKLLRFSANNGQLLSEVRNIHREECTSLDVSLDSRYLATAGDKVIKIWDYHMRLDQNYQLFIGHSSRINQVMFTPDMDGLISVGDGIFIWNFMGQDVTMNEYKEYKPRSTIPQPIPITQSPSTRRKLQLSNEDADEIEATSDQSEREDESNSVSASENYQDEELGVVSLQQETNVNLTSAGTKRRYAAPPNQAGLKLHSTVGYNGCGRGNMVWHPDTGFFAYTNGCIIVIEDLQTGKQTHLKGHIEEVSTLALQNDCQVLASAALESKDNGHICLWNTKSGICEKILKHHKGDICCLAFSRDDRFLISVGNYLDCAIVVWSTNDHSVLAATQLTEPIHDLCWDPYTVNEFSSVGANGKIKFWLLDETNYTISLNKSNNCVDFTSVGYAGDSILYAATNSGIITAWDTRNNSCFAHWEADKKEIGVIVCRGSRMVTGSCTNNLRLWSIVGIGEMRLPGGSVSEGLTMEDEMPLDGAIIAASFDESIDTGIVGTTAGTLWYINWPERASIRLVSGQTNQVNDVVFSGPDDKYFGTCGADGSLRIWTTDKVEQTLQFQVMGESTVVLKNVGADSITYPTHCVAGYSDGTVRLFDIEKIHMVMKMQPHANSVTAITYAADGSRVILSGSADGLIAINSPSTGLTLRVLNDHKGASILGFDVAVSWDEKWNLSSPLLWLGVSADRRISIWSADWSKDFCELVDWLTFAAPDFAPEETLIKGGLDFPPSLAAFSKTDSDIVIYTGYGIQKEIIFYSLSQQKIIRQCPLTHWMTSLDVSPKGQLIAMGCKERLVQIMDFYEGSFQDFVGHSDCIKTVKFSPSGNYLITVGYIDVLIWSVTV
The following text describes a protein:
Function:
Involved in the synthesis of fatty acids. Elongates C14 fatty acids to C18.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes predominantly in the perinuclear region.
Sequence:
MLMNFGGSYDAYINNFQGTFLAEWMLDHPSVPYIAGVMYLILVLYVPKSIMASQPPLNLRAANIVWNLFLTLFSMCGAYYTVPYLVKAFMNPEIVMAASGIKLDANTSPIITHSGFYTTTCALADSFYFNGDVGFWVALFALSKIPEMIDTAFLVFQKKPVIFLHWYHHLTVMLFCWFAYVQKISSGLWFASMNYSVHSIMYLYYFVCACGHRRLVRPFAPIITFVQIFQMVVGTIVVCYTYTVKHVLGRSCTVTDFSLHTGLVMYVSYLLLFSQLFYRSYLSPRDKASIPHVAAEIKKKE
The following text describes a protein:
Function:
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MEAILEDLHKLSIAELRQKMKEEGQPMGPITSTTRLLFEKRLAQALYSKNNPEHSGEDVPDSSQDAGSVSSSESTVTNSTNVTPSSQTAVSSGISNGSSSSNDRGGEDGSQAQVEEEVEGETTYYAVSLPPSDISLAAHANGLDPDQPHVYTKRSEALTTLKKIKGARFKAFKNRKDATDFSLQKTPPVPVVKPEADAEATKGERANNFKAPKVPELNRLRKSIEQGDKLTFTETVWTNPRFLISSGDTPVILQEGSRWSALHVAAKANLPNMCDLVLDILQDREFLQLMYPGDDPATEARRQKFLVDLYLNTPDKGNCETPLHFACKFGHVDVVRALVAHPSLDKTIKNRYDQTARDIICSRCPDGPDSKRAQQIRKLLEESYFVPLFRAEDNCLQPLVGEPWSPDQSGSPVRPLRHSQGSPVAVTPPRGAVSANPASPTMRVAAVAGPMSPAEAARFHQKWKTPPHSPDYLHVHNIRRGDNDRGLERIGRDLAHDLHIPWKEKWDFLKTNLDLATDEGLSKLEEYFATRNKCSEYENSKSVPKPSPPDICTATPCRESKVNVTPPECNSISMAAYYLQDDESDEDTLFTPTSDTKVTVDKSSPREIAGADTEEELDVADRDAIIMDKIKTNPFSPLLKDSSSSDIDSYLSWRESLGEATDATNTDEPDVNLSTFFAKLALRSPKQGSPSSEKGSTKIKGASSIDMCTPCRKGGPPKPFFIDGDRPTKLDLDVFHALQGVAIPTEKYPNIVRWRCVITSYTEQARQSWPSPAGLHRQRRHTFSTRSPLAAPSIMTGSQPRQGHRDTADSDNDDLKQELFRGEPEPKLTDIIYQWM
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MIRATAMHRSIVQRRMLSTASRLQQAAKPATGSTVGTANGASAASGKPPGATFEGASKQKKKTHKFRNFVLLSTFVGAGAFAGGVYYSLQNDQFQSLFVEYVPAAEHAINYIEEQQLRSGRLKIATPTSKHDVDQSTVRVPKSGATWRAVDSTDAATSAKSASSPAANVAKDVASPAPAATASPVSSGSPKTDNTTVPAVRLANDSDPAVKAAVQTFNDLIAVAPSGAAKQLSAKVSTVVDQLQHNVAQIKSEAAEEAKNSINKLNSELAKLKASTGEEISSKVSAAEQQLRNEFAALRAHSEKVYHDRLRVEIEATKSLVSSHANNLIQAVEAERQKQYAQEIAERVETEREGRLSKLKDLQTSLTQLQDLALKTEQAVDASGRTAALHLAIAKLTGALKGSEPVALGPYVESIRRAAGDDPLLQAALDSIPEVAQTEGVLTPAQLTIRFKLLEPELRKSSLVPVNAGVAGHLGSLIFSSLLFKKSGVPKGDDVESVLARANIALEQGKLYDAVAEVNTLKGWPRKLASDWLDEGRRRTEIEFLADVIAEEGKLYGALSSKK
The following text describes a protein:
Function:
Probably involved in the 3'-end processing of chloroplast mRNA's.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
CVAQTSEWEQEGSTNAVLEGESDPEGAVSWGSETQVSDEGGVEGGQGFSEPPEEAKLFVGNLPYDVDSEKLAGIFDAAGVVEIAEVIYNRETDRSRGFGFVTMSTVEEAEKAVELLNGYDMDGRQLTVNKAAPRGSPERAPRGDFEPSCRVYVGNLPWDVDTSRLEQLFSEHGKVVSARVVSDRETGRSRGFGFVTMSSESEVNDAIAALDGQTLDGRAVRVNVAEERPRRAF
The following text describes a protein:
Function:
Inhibits IL-33 signaling; Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MGLWILAILTILVYSTAAKFSKQSWGLENEALIVRCPRQGKPSYIVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAEVADSGIYTCIVRSPTFNRTGYANVTIYKKQPDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYKAHKSFLVIDNVMTDDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIRAPAHNETKEVEIGENTNLTCSACFGKGAQFLATVQWQLNGNKITDFSEPRIQQEEGQNQSFSNGLACVNTVLRIADVKEEDLLLRYDCLALNLHGLRRHTIRLSRKNPIDHQSTYCIIAVCSVLLMLINVLVIILKTFWIEATLLWRDIAKPYKTRNDGKLYDAYVIYPRNYTSSTDGASRVEYFVHQILPDVLENKCGYTLCIYGRDTLPGEDVVTAVETNIRKSRRHIFILTPQITHSEEFAYEQEVALHSALIQNDSKVILIEMEALSELDMLQAEALQDSLRHLMEVQGTIKWREDHVANKRSLNSKFWKHVRYQMPVPSKMPRKASSLTSLAAQKQ
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Can use NTPs but not dNTPs. Binds DNA. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
Sequence:
MSFQMKYDIRLRFEVEGIVEKTDVIGAIFGQTENLFGDEFDLRELQDKGRLGRIIVEVKTKGGKSEGEIIIPSNLDRIETALIAAMVESVDKVGPYNSKFELIEIEDIRAEKLKKIIERAKGILSSWSKEKSLDIKEVINEISSAVKVGEITEYGPERLPAGPDVDKDPNLIIVEGRADVINLLRYGYKNVIAVEGATSRIPETLINLSKMKKTVIAFLDGDHGGDLILKELLSNNVKIDFVARAPIGREVEELTGKEIAKALSNMMPLTQYLKKVQEAEQAIAKNVIAKEEKPIQSETTQQVVQITLPQNILEEIKKLPGTLEGVLYDNNWNLIEKVQVRDIIPKLEAYEDNKVAYIIFDGVITQRLLDLASQKNIKMIIGARIGGINKRPQNVDILTFTDIISS
The following text describes a protein:
Function:
May be involved in a fimbrial system chaperoned by YqiH and exported by YqiG.
Sequence:
MRYLLIVITFFMGFSSLPAWAMDCYAEHEGGNTVVIGYVPRISIPSDGKKGDKIWQSSEYFMNVFCNNALPGPSPGEEYPSAWANIMMLLASGQDFYNQNSYTFGVTYNGVDYDSTSPLPIAAPVCIDIKGAGTFGNGYKKPAVCSGGPEPQLSVTFPVRVQLYIKLAKNANKVNKKLVLPDEYIALEFKGMSGAGAIEVDKNLTFRIRGLNNIHVLDCFVNVDLEPADGVVDFGKINSRTIKNTSVSETFSVVMTKDPGAACTEQFNILGSFFTTDILSDYSHLDIGNGLLLKIFHNDGTATEFNRFSQFASFSSSSAPSVTAPFRAELSANPAETVVEGPFSKDVILKITYN
The following text describes a protein:
Function:
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MRLWLRGLVYQARRSSWGVFRIHTQPPPPPIPEVVATWEAISLGKRPVPEYFNFAHDVLDVWSQLEKTGHRPPNPAFWWVNGSGTEVKWTFEELGKQSRKAANILEGACGLKPGDRLMLVLPRLPEWWLTIVACMRTGVVMIPGISQLTQKDLKYRLQAARVKSIITSDALAPHVDAISADCPSLQSRLLVSDTSRPGWINFRELLRVASPEHNCLRTRSGDSMAIYFTSGTTGTPKMVEHSQCSYGLGFVASGRRLMALTESDIFWNTTDTGWVKAAWTLFSAWANGACVFVHELPQVDAQTILNTLCRFPITTICCVPTLFRLLVQEDLTRYKFQCLRHCLAGGEALNSDVRDKWKNQTGLEIHEGYGQSETVLICGNFRGSTIKSGSMGKASPPYDVQIVDEEGNVLPPGKEGNIAIRIKPTRPFCLFNCYLDNPEKTAASEQGDFYITGDRAHMDEDGYFWFVGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLSPAYVSHDPEALTRELQEHVKTVTAPYKYPRKVAFISELPKTVSGKILRSKLRNQEWGR
The following text describes a protein:
Function:
May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.
Sequence:
MPGLKLVEALEYRCDRLERLIGAGYSANSDVSVQLDELYNQLHRLYFQGLKYSQDLLQLFNTFMAEDIENVGAPDDICIFASCFDDIYTLYSAFDELNSQYMEFCQISKSSLDQISFKDANIETKQLKKLPELVDNCNIMILRSIAILNRFIDWNIEVNGFFQFQKKRLLNLQKVIYST
The following text describes a protein:
Function:
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MEGGWPLVWGGGGVGFPLCLTVSLLLRGKMGHFTINCSGFDQHRVDAAVFQAIFNQKAFCPLINYSIPTHVNISFTLSAISELWVSAITISLWTNLWLPHIIIMKSWVSGTDVDQTPDGLSVCVTNDSCVVYNTPMWVTSICSLDIFYFPFDQQNCTLTFSSFLYTDDLYPLLENMLLGMDKEILGISKTTPKMAVGSNLFDQIMFYVRRRPTLYVINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPISGTPLISVYFALCLSLMVVSLLETIFITYLLHLAATQPPPLPRLLHSLLLHAPAQGNKEPRELGGKELGPREELNRDSGLTKAQLVDLWVQCNHMMDSLHFRLYLLFLAPPSPRSSSSGTSRSRVLMVQEH
The following text describes a protein:
Function:
Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins. Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis. Regulates the quiescence/cycling of hematopoietic stem cells (HSCs). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVCQLPGLFSYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQHYQESDKGEELGPGNVQKEVSSSFDHVIKETTREMIARSAATLITHPFHGISKRILIYFTFSSCVRSGLCDSIITIYREEGILGFFAGLVPRLLGDILSLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCPPYSPIYTSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLKMLI
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSVVPMPHASGKINKFAMTERHLDFLHETVRKNPESYKEEFLEQLMQMSQGEITIQIEHAHRYQQSREPQKFQIIQPLLDSITFLSGVVIFFKEEAKAFGDQILREQATGLDPHVRMAFCKALIPLRNNFIEPLTLLELKFILSSILSHLKMICVQKKNLRLAGKIQNFCFARLKDSQSIVVRSCQLILIDVFRKKYFRCANIRTNKNSRGKECNLLAVQSLYDAQEFGDRLFKMLESTKIEKFEVRLFRIALLARIIGIHRLQTLQFYSYVQRFLQPKQRDVTRILLYAAQSCHELVPPDTIESLVKCIAYNFVTDW
The following text describes a protein:
Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
The following text describes a protein:
Function:
Positive regulator of brassinosteroid signaling.
Subcellular Localization:
Nucleus.
Sequence:
MANLSSDFQTFATDDPITQLAELNNTLTPFQTIKTLMESVSTSENSVSDQTLSTSSAQVSTNGTKNSWKRSKNREEEKERVVVHVSAKRGQATDSHSLAERVRRGKINERLKCLKDIVPGCYKAMGMATMLDEIINYVHSLQNQVEFLSMKLTAASSYYDFNSEADAVDSMQKAKAREAVEMGQGRDGSSVFHSSSWTL
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MDPTIHILGLGNLGKLFAHSLATKPEPPPVTLLFHRHSLYHKAKALGPKIKIYHDGVWLGGGHYDIELCQDGNKNRSDTKVISNLIVTTKSHKMAEALEMIKHRLSRMSTVLFVHNGIGVVEEVNKLVFPDFKDRPRYLFGIASHGVSQQTPLTAVLAGHGFVTIGNPEMDKEGSPVKSHLLRQVIDSKLLRASEVPWDEFRLLQLQKLAVNAVINPLTALNNCLNGMIMESSMIGDIGDLFGGLVSEISQVICSLPELQGIPGLEERFSIETLRNIILDVALATAGNRSSMLQDVSNGRETEIAYINGYIVGRGKELGIECPVNRRMVTDILEAVSKQKLQAV
The following text describes a protein:
Function:
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MGQDYYAVLELGRNATDADIKKAYRLLALENHPQKCKEPLAQERFRLLAEAYDVLSDPVRRGIYDRFGEEGLKGGIPVGSDGEDAWTAGYVFHNNPDKVFKEFFGGHNPFAEFFTKDGLEVTLPFGGLHGRGVMKQDPPMVWDLHVSLEDLFFGCTKKMKISHRVMNEDGQTSTIRDKILIIDVQPGWKQGTRVTFEKEGDQGPNIIPSDITFVVQEKPHPRFKRTNDDLIYVASIPLGKALIGCTVDVRTLDGRLLSIPINDIVHPTYCKVVPGEGMPLLEDPRRRGDLLIHFNICFPKRLTPDKKVLLRRALLS
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYWKNAWWVGTVYSSCEPIELPEGMLISKQYETYPITTVSKAIYKQMCYRNCIPVLNTNVGFVIDTFAKPLPIVSQSWREFTKDSLRGSFAYSVVSIIYAIAVSAVIIWFLTIFVLTNYTIKPSWLLKTSTILSTVYILVVVIKSILILHGQQRDGYLHGAKLLSELNDYNPIQIIDLIVVLLLQINQVQIIMRIFQRQKDKRMALLIGIVATLASQVIWAIAQFYTPADANEASDILPAFIYLVRIAMALCYAAIITVFFISKIQIILANKKIWLLTLLTFILIYSPVAFFVADVSNAFVYELSEIFSVVNYVIGVVIPWEWCNKFNLIMKAKEKEGVLGRRFYEDELYELDRFELFVEEQMPEDEDNGDTHSDSPGNELNGGAHHNSQEQSDRLIGSNSPTNKPHNGNNTDPTSRFRQLLTNTKDAFLTLTDNIIAAGFAIPRSVSVSTQSLTGRYRNNSTARTEYTKEVVPDFSPEMFLQPEGSSHITETLSEQNAAPSTTNSNHRRRNVYVYSRKEVILDVSSDE
The following text describes a protein:
Function:
May be a regulator of microtubule physiology.
Miscellaneous:
MISCELLANEOUS: Shows no detectable enzyme activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Dynein axonemal particle. Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette.
Sequence:
MGSRKKEIALQVNISTQELWEEMLSSKGLTVVDVYQGWCGPCKPVVSLFQKMRIEVGLDLLHFALAEADRLDVLEKYRGKCEPTFLFYAGGELVAVVRGANAPLLQKTILDQLEAEKKVLAEGRERKVIKDEALSDEDECVSHGKNNGEDEDMVSSERTCTLAIIKPDAVAHGKTDEIIMKIQEAGFEILTNEERTMTEAEVRLFYQHKAGEEAFEKLVHHMCSGPSHLLILTRTEGFEDVVTTWRTVMGPRDPNVARREQPESLRAQYGTEMPFNAVHGSRDREDADRELALLFPSLKFSDKDTEAPQGGEAEATAGPTEALCFPEDVD
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage.
Domain:
The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif also mediates interaction with ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs) (By similarity).
Sequence:
MKMAAVGSAKSTGPGQRSKSRPGALSAPLSLEEARCPVCSEILLEPVTMPCGHSVCLHCFQRTVKLISLCCPLCRLRVSSWARKQSREKSLVNAELWELVRLSHPERCKRRMEQRDGEIPDGEIFRAPVPVHKVGEMRQEYEKQKMKSGRSEETDERKKKMHIKEECVLLKHCQYPFCGVSDSENEEPVGRRTRHVSAFVRKTRCSPAFNKSCLHSSAAQRSRSCTDSEDGRGKSRGHTNQAVPEKANIAHSYNAGILLSSENSRSFSAPLLSLDKRHHWRGIHTSSATLVLQTKPERSISPESNDSISEELNHFKPIVCSPCTPPKRLPDGRLLEPMIVKSTPRNLTRALHKSTSYEASPTILQKWKQIEVDRQCIKVTSKGTVTSPIAEDLNLKLSPVEERDCQPCSCSVAKDRLLDLQCICGSNAHKSKSRKDKPIIYNKRRLIFDPYNKGEEKTQVAALIKTFGDSSTPKACKELCEPSEMGPPMLDSNAGHCNQGTVDPDHNIKINEPTTMSCVLNRPTSRRGKKRSQKTKHMEETLQTKISRTNRYDSLDDLIVQRMSQEKEDRELALKLQRQFDRECKKVDRHKTSRNKYELRSWGSKDGIVGYNTRRSGRVSKQNEHFNYTC
The following text describes a protein:
Function:
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS) (By similarity).
Subcellular Localization:
Endoplasmic reticulum. Note=Soluble protein.
Sequence:
MLNVPSQSFPGPSSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTDLFDQVHRWVNYESMLKECLVGRMAMKPALPKDYHEEKKVLNGMLPQSQVTDTLAKEGPSSPSYDWFQTDSLVTIVIYTKQKDINLDSVIVDHRDDSFRAETVIKDYSYLVHVALSHEIQEDFSVLVVENVGKIEIVLKKKENTSWKCLGHPQENHNSFIPKKDTGLFYRKCQLVSKEDVTHDTKLFCLMLPPSTHLEVPVGQHVYLRLPITGTEIVKPYTPVCDSLFSEFKEPVLPNNIYIYFLIKIYPAGFFTPELDQLQIGDYVSVSNPEGNFIISQLQELEDLFLLAAGTGFTPMVKVLNYALTNIPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKDKRFEVEFVLSAPTSEWSGKQGYISPALLSEFLKRRSDTSKVLICLCGPTPFTEQGMKMLHDLNFSKDEIHSFTA
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MNPINGHASWNSIESLLLPSTLVTIQSLGFQTMTPVQSATIPAFLSYKDVVVEAVTGSGKTLAFVIPILQMLSKRDTKLRKYDVGAIILTPTRELAIQIHTVIQPFLDNMQDLSQILFIGGNNTVNDAKMWKEYGGNIIIATPGRFEDIIDRRKTDFNIAGHIKALEVLVLDEADRLLDLGFEESLNTIFSYLPKQRRTGLFSATQTEKLEQLIRAGLRNPVRITVREKNIVKQVNQKTPAALENYYMLCGFDTKFSNLIHFLKERKNLKHMTFFSTCACVEYFGNVLKCLLPDMCILCMHGKMKKKRTLIFEKFRKMSRGLLVCTDLLARGVDIPEVHWVIQYDVPNKTNAFVHRCGRTARIGNKGNAIIFLNPNEESYVQFLSLNQKVPLARFTSNHEVADYTQKLQELSKSDREIYEKGIRAFVSFVSSYRKHECSYILRVKELDLCSMARGFGLLRMPKMPELRNVNTSLFETVDIDVDAIAYKNKAKEKQRQIALKNQR
The following text describes a protein:
Function:
Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation.
Subcellular Localization:
Nucleus.
Sequence:
MDRDSSMQAKNLDAQCNPDLKMASANSETLASATHELKIMDVEGGALVDPDHIEEVETSMVIVVDDDDGDVAMVVEEDKHPMRDDPCIEDIMDDEHAPLVAELQSALNNPDDKQASEDPLLEDQEREPDAMSTKTEPSSDAESSHSYHDPMGLLERIEIHDPGDSQDDDDEDDESSNGGGVDGGMRRKMPRAQRWLLWMKRWPWILHEDSDGTLAFCLYCNISINVNNRSRHIQQHNVSLSHQERECNYLAFKKSEEETRGAISDNEIKHEFGTKSYVAAMKQKRISETEAFNNFNWLRWLRWHPWLERSMPTGTIGTCRICSVRMNVEFVYLRKRHETTKGHMEALRNLDSDKRSRKRKRSKSNSVTNSGGDEAEREKESEPEVGPEDAQDTPVVMMNGDVDSGDDPGKWCALIPDTNPQQCRCTLCNCTMAITSFLRHCKTRAHCHMLSTPAEKGSSDIRGIWAVFADMHPWLIADPEDPSIGYCSVCRKRFMYGNSEIKRKNHEKSEKHTLALASAKAGIEVGSADGRGGDNMDEEEAAASDQAQSSQTDDSEDNDDDNWSEIQKLGKGFAHKSSSEPRKATVRAGVRFYPWLCYSKDRKTQICKFCRVRFHNEAAKARHELSARHVKLVKQFKMRQAKLHQGTNTQTKHNAQDDEESQEQDEEYGEEEEDAEEDSQSNFDLGTVQARKTARADNKLFVKPIPATMKGKVMVWKGRFPWLSYKKNEQRGNYAWCKLCEVSLYLPSSKWASKHQRTSRHIRLRIDRKRNGGNPLKTSNKNSGEISTVVATASALASAEARQKAAMAELQAKYDWLDPDANDENHCHCRVCDSRLPIKVFYLRQHDASRKHVENKERQRANAAAAANAPSVSPTSTVDAERQESGMDKESENDMSVRSDGSTAEPLAKRSRRSMEVRRIIRALRDSMGKRQEERSQMDMARDMICSSFDIVTRLRTLERESVAHNESMAQAPPSVTVSPIKPPEPRHVMDLFFDSISPTMKSLPPDLAAEGKSKIMQLVCSLELRAMQRNATTPTPATVSASSKWPSSTTVTPVKTPPAPISAPLASVDADLHSSVVTTPHEYNNGQNNNNDKETVPKEPVTGASSAQVTINGSAKDLPENIRRILTSNQTQVTNRLETDSVRCVPLDKLTTQSRTNVNGRLSQGGTSEAPSTPQADLSNGNTLAMIRQIRVNNNNSSKITVTNTPQMQQPQQAQASITSSTPIMRGGPSSNGCQITTFRTMVNHNRRP
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
CKNGHISCRECWIRQLSIKKECPTCKVKTDMDSLSRNIFLENSFRKNLVYCPYLFKESKFNNELIKDDSGCRAKITIEEFENHINICQYKFCNCPNNETKCKTITRKNLTTAHNEVCEYVIVSCDGCEEPIEKCELRKHKETSCSATKDKCTVCFEDVGRTLLKQHIDHECKKILIDCLYKNGGCTDRFERGLINEHLSKYNNHIFFIQNMINKETKFEEISKEFKNILDINAQLEKRIKHLETTISLNRDSSSVNLQKYIGKWTINNWDQKVATYTAGRSFNSPYFFIGSFQFFLMIYPNGNADARNHVSIFLYKILDKPTTVKYCLEAKNADPTKNYKNSHINHFSTNNGNGWFRFIDNKVNNGFFTNNQLVINIKVKTLPTQENIETN
The following text describes a protein:
Function:
Could be involved in the unfolded protein response (UPR) pathway.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MDQSGMEIPVTLIIKAPNQKYSDQTISCFLNWTVGKLKTHLSNVYPSKPLTKDQRLVYSGRLLPDHLQLKDILRKQDEYHMVHLVCTSRTPPSSPKSSTNRESHEALASSSNSSSDHSGSTTPSSGQETLSLAVGSSSEGLRQRTLPQAQTDQAQSHQFPYVMQGNVDNQFPGQAAPPGFPVYPAFSPLQMLWWQQMYAHQYYMQYQAAVSAQATSNVNPTQPTTSQPLNLAHVPGEEPPPAPNLVAQENRPMNENVQMNAQGGPVLNEEDFNRDWLDWMYTFSRAAILLSIVYFYSSFSRFIMVMGAMLLVYLHQAGWFPFRQEGGHQQAPNNNAEVNNDGQNANNLELEEMERLMDDGLEDESGEDGGEDASAIQRPGLMASAWSFITTFFTSLIPEGPPQVAN
The following text describes a protein:
Function:
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDPTVVLITGCSSGIGMHLAVRLASDRSQSFKVYATLRDLKAQGPLLEAARTQGCPPGSLEILELDVRDSKSVAAAQACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFYEKLVGGPGGALERADAQTRHLFAHYLRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVAAMHQEAFSNLQTQENAKAGAQVPGVSDTASSALICLPECAIPRVASELGWSASDKPGQDNSCYQQKI
The following text describes a protein:
Function:
Serine protease involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition). In P.anserina, the het-q locus exists as 2 incompatible alleles, het-Q1 (AC B2AXJ5) and het-Q2 (this entry). Prevents cell fusion with strains containing the gasdermin-like protein het-Q1 by mediating proteolytic cleavage and maturation of het-Q1 during the allorecognition process, thereby triggering cell death.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSAISHHSLSHLNSTVSKRLMPTYSDPVVRIAVLDTGFDGSHPDFSHPRTAYFTGPFSDLPQPEKDEEPQLTRIKAYHDFCQPSPPGDRQGPPPQPHSMVDLAGHGTAIAGLILRLAPRAELVIGRVCHGVDSNELSAPDPSRVAAAIRWAITQKVHIINLSLGYRNQPLKELLPLRAALLEAQRSNILVFASTSNQGSHEPAAWPASDARFAIGVHSCNDMGSAPSGSSCKASENGYNFMAVGENLLVHRLAQKGGGFELVSGSSFATPVVVSVAALVLAFVWQEECKRERDEVGREVMLEDLGSLGGMGRVLMALGEKTAGSYWAVGMKLFWAGYREGDGRDPEKEEKEARRWAWGVLRGAVAY
The following text describes a protein:
Function:
Binds to and supports processing of specific plastid RNAs. Associates via its C-terminal Rho-N domain to single stranded regions of 16S and 23S rRNAs or to rbcL mRNAs. May be involved in targeting transcripts to RNases such as RNE or RNase J.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAMSGTFHLTSDYVPGYTLSDSRCFFNSAVSRRTLAILPCSSCLDHKNGRLKSVPNRSSFVCRASSGGYRRNPDFSRLNKHGYRGNNRQSGGREDFDIENSDMLSSRNGPLFNLSSSPKFQATSSPGPREKEIVELFRKVQAQLRARAAAKKEEKKIEEASKGQGKESETVDSLLKLLRKHSGEQSKRQVSKFSSQGEVQGDTVDKQDRTGNLVTSGNKDNNASSFTRPTSSFRRKSPVPRSQSPPAYSSEATFDQSSSYSVTWTQKKDTVELHDEPEHEPAYEHEHEPENESEPGPVTTMLEPDSELKPESSSFYQEEEDDDVTFDVLSQDDGILDVLSDDDESLDDADEDSDEAEEEAVKDLSELKLVELRGIAKSRGLKGLSKMKKAELVELLGSDSS