lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes.
Subcellular Localization:
Cytoplasm. Nucleus. Presynapse. Postsynapse. Note=Localizes mainly in the cytoplasm.
Sequence:
MISAPDVVAFTKEEEYEEEPYNEPALPEEYSVPLFPFASQGANPWSKLSGAKFSRDFILISEFSEQVGPQPLLTIPNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVEDSKVVLGDSKEGAFAYVHHLTLYDLEARGFVRPFCMAYISADQHKIMQQFQELSAEFSRASECLKTGNRKAFAGELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVEKSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRPAYTPKLIKAKSTKCFDKKLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRALLKQQHITNFLFEDFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKSSVESVLIKMEQELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAINEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPSTPAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHLLASRDISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDRHKKRAGQNALKFIRQYPFAHPAIYSLLSGRTLVVLGEDEAIVRKLVTALAIFVPSYGCYAKPVKHWASSPLHIMDFQKWKLIGLQRVASPAGAGTLHALSRYSRYTSILDLDNKTLRCPLYRGTLVPRLADHRTQIKRGSTYYLHVQSMLTQLCSKAFLYTFCHHLHLPTHDKETEELVASRQMSFLKLTLGLVNEDVRVVQYLAELLKLHYMQESPGTSHPMLRFDYVPSFLYKI
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MAFGGYNDVSNHGHQKKHKKYAIIGVSSLLLVAMVAAVAVGATRNKADGSSKSDGNGEVSTSMKAVKAICQPTDYKETCEKSLSSAAGNVTDPKELIKIGFHVTVQEIHAAIANSTTLKNLAKDPRASQALENCKELLDYAIDDLQESFNKIGAFDVSKLDDYVADLQVWLSGAITYEQTCLDGFENTTGDAGDKMKEVLKTTQELTKNGLAMVTEISNVLTNLQIPGLNRRLLWDEDPSGAGFRKTYDEPHDKDPTSTNRQLLWDNGSGFDQELADPQRKPVEATNRQLLWDNGSGFDERHDDKQRKPLESTNRQLLWDASGFDDDLDDRQRNMESTNRRLLWDASGFDDDLDDRQRNMESTNRRLLWDAGGFDDDLDDRQRNMESTNRRLLWDNGSGFDERHDDKQRKPLESTNRQLLWDASGFDDDLDDRQRNMESTNRRLLWDASGFDDDLDDRQRNMESTNRRLLWDASGFDDDLDDRQRNMESTNRRLLWDASGFDDDLDDRQRNTESTNRRLLWDASGFDDDLDDRQRNMESTNRRLLWDASGFDDDLDDRQRNMESTNRRLLWDASGFDDDLDDRQRNMESTNRRLLWDASGFDDDLDDRQRNMESTNRRLLWDASGFDDDLDDRQRNMESTNRRLLWDNGSGFDDDLDDRHLPAWINGRQRKLLGSTNTGDIKADVVVAKDGSGKYKTINEALMDIPKNNNKTFVIYIKEGVYQEHVMLDKHMTHVTMIGDGPTKTKITGNKNFVDGTPTFKTATVSAIGSNFLAKNIGFENSAGAEKHQAVALRVQSDMSIFYNCQMDGYQDTLYAHTHRQFYRDCTISGTIDFIFGNAAAVFQNCKMIVRKPMDNQQCIVTAQGRIDRREPTALVLQGCTFTAEPAYLPLKDKNKAFLGRPWKQYSRTIIMQSHIEGFIQPEGWLPWMGDFALNTLFYTEIDNDGPGAATTNRVKWRGIKKVNLEHAKKFTAGTFIGGDKWIKPVGVPYVSGLM
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Sequence:
MLSFDLGKEEFLELVSGLEKPGLVQLFAKVEGCSPACSPLELYGALRGSGTTGYSYLLESVEKQESRARYSFVGNDPDAVLKINDRKISLELLNPKASPLFEAICTKMEEVCGPETAEKENESKKNAGPEKFTAAIPRGKDVFDALRLAFPPANGIELLNSRRFARQTFLGGAIGYTAYDAIYDSWLGVEKGFESDIPDLQYLLVSKSFVLDHLTEEVYIVLTPFVSPGSDAEQVYEEALSEAERFYSVIKKATQPEDAAKAAEGIIASGTDVSGPAKAPNSNVQVCSVDRSGFEESVLQAKEHIFAGDIFQVVLSRKCEFKMEQSPFELYIQLRAINPSPYMYIFEFGDLAIVGASPETLLTVHKRTVIINPIAGTCPRGKSEAEDETLASHMLNDEKERAEHVMLVDLGRNDVRMVSESGSVKVSGFMKVLKYSHVQHIESTVSGTLRPECDQFDAFRAVFPAGTLSGAPKIRAMEIISEREAVPRGIYGGGVGYYSWNGDADFAIVIRTLLIQGRKASVQAGAGIVADSDPAYEFRETDRKMAAMLTAIGGEIRVEK
The following text describes a protein:
Function:
Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide (Probable). Also can mediate a very low unidirectional transport of anions including sulfate, phosphate, (S)-malate, citrate, L-aspartate and L-glutamate. Maintains oxidative balance (through uncoupling activities) and ATP production (by modifying mitochondrial membrane potential). Is able to transport protons across lipid membranes. Also exhibits transmembrane chloride transport activity to a lesser extent. May modify mitochondrial respiratory efficiency and mitochondrial oxidant production (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGIFPGIILIFLRVKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MEMKRRVRAVRRDQIQKRWRPLEDKQRQEIIIIFRTCSRLVLNTIKSETRKSLAEEWFMNILLKIEAPLRNLPVPRKRKESILFSQLLSSNMQLEQQLYSDLDHINVLQQELKVETARLENEQKSYEEMKQNMAINNSRLADLKSKLHPYLKKGLKISHDNFSDSNDFSFQKKLNTEDSNTSKTSTLDMYKEKLKPFTKTMQIHANKTVQLSQTIQKATLLLQRLNNTKNIGLNKSSKLKIKNI
The following text describes a protein:
Function:
Required for the establishment and maintenance of sister chromatid cohesion during S phase. Prevents their formation until eso1 is present. May also have a role during meiosis.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Localized to chromatin throughout the cell cycle.
Sequence:
MIKLQFQRNIVPTHDNPLTTSEILKRLRDLLGELTSLSQDTIDRDSVLPVARSLVNNNLLHHKDKGIRSYTLCCIVELLRLCAPDAPFTLSQLEDIFQVILKILSGLMNQESTYYPQIYEILESLSNVKSAVLIVDLPNAEEFLVNIFRLFFDLARKGTTKNVEFYMLDIINQLINEINTIPAAALNILFAQLISGKGVRQTIGSSDSTNHGPAFQLARNIFHDSADRLQRYVCQYFSDIIFDSRDSLSDSMTTPEFIFSHNLVLQLWKYAPTTLLNIIPQFENELQAEQTSVRLVAIETVGLMLQDNAIWSDYPRVWSAFCGRLNDKSVACRIKCIEVASNALQNSLATSEIIENVVQMLQSKLADTDEKVRVATLKTIEQLTFETFKMQFSVQALKLMGDRLRDRKLNVRLQAIRTLSQIYNRAYQDLIDGVEYSIQMFSWIPSSLLEVFYVNDETTNAAVEICMAELVLQYLSSDTQTRLNRLFLSIKYFSEKAMRVFILLLQRQVKYSELLNYYIECCKNYNGGVMDNDEESITNKLKKVIDIISSKSSNPTLTEATFRKFAELNDRQSYKMLLQTFSIKSEYQVVLKSIKYLFKRVSETLSTASLECFRIFVYRSALFAFNKSNVHEIIQLLNEPVKYHNFLKPSEALLQHLPLIHPNIYGEVVIEVENIIVSSGIESDPKVIKALSQFSKRKKNFSIQTTTAEILRKLCLHGTQEQAKQAATIIAITETKEFKLDMITNIVENLEYNGGLPVRLMTLGQLFLYTLEEVEKVADQVTEFLVKKVIQRFPEKYDDTHNDEEWCTYEKLDNLTMCKVLAIRVLVNRLRAAAGGTEALNIGAPIIKLLKVLLMADGELSPFKNTPKISRAYLRLTASKYFLKLCSIPFYAEHIDFSSYVQISLLCQDENFDVRNLFLTKLQKQLQLKKLPISYYPLLFLTAVDPEEEIKTKASIWIRSQVAFFQKTHDFTMEYVATYLIHLLSHHPDISSIESENSLDFIAYIRFYVDTVVNSENVPIVFHLMQRIKQSYDVIEDGNNYIYVLSDMAQKILQVKSQNFGWSLTTYPKQIKLPYEILRPIPSIDEKKRIFNKIFITPKMESQIEHAIRTPVSSFAKQTTNKHANLKQKKTHSSKSDKKSSRRRKNEKRRKLNEQNPNIRNVPERSSSRFQGIRINYSEAPSSSEEISEEEEEISEEDFDEIEDL
The following text describes a protein:
Function:
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRKRIDIITLGCSKNLVDSEQLMRQLEEAGYSVTHDTENPEGEIAVINTCGFIGDAKEESINMILEFAERKEEGDLKKLFVMGCLSERYLQELAIEIPQVDKFYGKFNWKELLQDLGKTYHEELYIERTLTTPKHYAYLKISEGCDRKCSYCAIPIITGRHISKSMEEILDEVRYLVSQGVKEFQVIAQELTYYGVDLYKKQMLPELIERISEIPGVEWIRLHYAYPAHFPTDLFRVMRERDNVCKYMDIALQHISDNMLKLMRRQVSKEDTYKLIEQFRKEVPGIHLRTTLMVGHPGETEEDFEELKEFVRKARFDRMGAFAYSEEEGTYAAQQYEDSIPQEVKQARLDELMDIQQGISAELSAAKIGQQMKVIIDRIEGDYYIGRTEFDSPEVDPEVLISVSREELEVGQFYQVEVTDADDFDLYAKILNKYE
The following text describes a protein:
Function:
Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases.
Subcellular Localization:
Cytoplasm.
Sequence:
MPKYLINFVQQYASFRIHELESVARLFNIDIQYNKEDLEFIESLDPEIETPFLYVTVNSEEDIKKICTRSVLIKSVYSIWAETQLLDEILNELHSKFDKQFLSNYMINKTFKIEVESYGSKYNQKEKLEMMQKLKDSPLWDSGKCLMHPTEEQMDKHILWYILTDFGVERQGLVKDFTLLPRKVYFGQRIAKGNRDDIIKYNLSDRKYLGTTSMDPELSLVSANMGLVKKGHFVLDPFVGTGSFILVASHFGAQTVGCDIDIKAMRKEEDCNLETNFKDHGLTSQFLGTILCDNSCPPWRVNSMFDSIITDPPYGIRAGARKIGFKENRKFVPVPEGLRRDHIPQCIDYSVPDVMADLLELAAKTLIVGGRLVYWLPTTPDYKETDLPRHPCLRLITASCLQILTNRWGRRLVTMEKIIEYNDSIHNKSLLVQEDLGQFDPQHKDLRAVVFWKKMGTNEKTKKKEQKKKSVENHLKSKNNNDVINNNSNDTNSNNNCNNENNIENQK
The following text describes a protein:
Function:
Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTERFTLFEFNLHIDENLFIKALKYTFIFGLLTYLSVIVAPSPLEFQFYIAYSTLLAGAFLIVWKRFNFGYTHYLTVYLLVFIMLRYFWWRTFNTINTDNVWNFIFSTALYFAEFYSVTIALLGIFFSIRPIDRKAIKVDMESLPTVDVFIPTYNEPPEIPETTALAAINMDYPSDKFNVYILDDGGTKQRLNDPDPERREYFRKRAEELKSFVERLRKLGYKNIHYLTREKNVHAKAGNINEALKKTKGDLILILDADHVPSKDFLKETVGFFVKNPKVFLVQTPHTFYNPDPIEKNLGVFGRMPGENEMFYFLIQKGFDLWNSSFFCGSAALLRRKYLEEVGGIQTTTVTEDAETALELHSRGYESVYYDRPLIFGLNPETLSGMIVQRIRWAQGMIQIFILKNPILKKGLKWYQKLAYFNASFFWFFGLARTIFLIAPLAYLLFGLHIYDASLAEVLAYPIPHFLASLLLFYYLFSRVRWPFISEIYESILGIFIFIPSILTLLNPKNPTFRVTPKGELLDRDYISPFYKPYFILYHLILLGYLFGIYRWIQYPDERGTVLITLWWNTFNFFVMTVALYVSYERRQRRKFHRIPSNDQIIIYRDSETLLGRVIDISLGGLAVKLETKPKEEFKEGEEVKGVIRNVENKLVYIKPKVVRYEKDRNILRMKFEWKPEDVETVSKIVDIVYAPSSRWVILLERERELTPFEGFVVLTKQILRDFGQVYISIYNYFKNDILNTVWNYIRRGIKWGLSFSS
The following text describes a protein:
Function:
Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MTSILGSARPLIQVGPKSRNASTSMSRLPSFPTTRPCRRAPCSSSSYATISPTAPRSSQRNPTNASRHPRIDEVDHIPTSALGRVLLTAGSALGLLNNPSRGDLLSMLTQVSSGPSLAHLLESMRSTESGRRLLIERPSVNSETVDVDYLASLERGKFGREWIEWLKDNGVGPDGRAEADYMTTLEHKYLIQRYRESHDFYHLLLRMPVTQLGETVVKYFELAQMNMPVAGFAAAGGTLRILASSLSALPKPSQLISAALNRSPAPETAHQPPSSADLSALQTLIPWAMQVGSSSVPLISIEWERCWERDIEEMRREFRITSPPIQVAKFSGRAKKGGKRRGWPSKILEHQKAQHQQQQQQQKVDESRN
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (Probable). Inactive cysteine protease. Deubiquitinating enzyme which regulates gene expression by contributing to chromatin organization and DNA methylation patterns (e.g. H3K4me3 and H3K27me3). Involved in the interpretation of environmental information, probably by altering chromatin organization and maintaining redox homeostasis. Required for phosphate (Pi) homeostasis (e.g. responses upon Pi starvation including DNA methylation and histone methylation). Negative regulator of root hair morphogenesis.
Sequence:
MADNKTSEGIVSEETPMDASQEQQHETVEEMLARHRQEIKQLQNKETEMKKAAAKGSKAEQKAKKKQVEDDISKLSTKLKDKQLKELASQGFSSSSSNNIAKDETTEKKGDIDTLVRAIAGVSVTAQQEHSKPSKSVKRREKRAKEEADREQRIKEEQSHVKSDRMVENAKLEKKLKPLGLTVSEIKPDGHCLYRAVENQLANRSGGASPYTYQNLREMAASYMREHKTDFLPFFLSETEGDSNSGSAEERFEKYCREVESTAAWGSQLELGALTHCLRKHIKVYSGSFPDVEMGKEYRSGDDSSLMLSYHRHAFGLGEHYNSVVLVNNITG
The following text describes a protein:
Function:
Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin.
Sequence:
MKVLYFAEIKDILQKAQEDIVLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MYASKENAWEGYTDDRFYGAKRFREYWQRMLADRGVRYYMFTVIVLMMAATAKLWQMQNLQREENGLLGPRKKQYRSRLTIVLDVDETIVSYGDKAFRLKAGLVPRPYLAELLDYLTSIDAEVVLWSASSERYMRQVLGIIDPMGVRVSQYLSRGREWFTHDNYYEKNILWLKRPLEDTLIIENRPLSVRNCNGNAILVDDFIRGEYMDTGQDYPANDHALRTIKSIVQDLETSGMSVPEYLANHKVRHREIKEIPCHLAIRQLPDEIARGVFYFVGDKYKTKPNAA
The following text describes a protein:
Function:
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and may play a role in limb development. May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3' (By similarity). Has an essential role in the early embryonic patterning of mesoderm and neuroectoderm.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MEAQSRSTTASEKKKVENSIVKGHSRTEVSEKAVASSTTSNEDESPGQTYHRERRNAIAMQPQGGQGLGKISEEPSTSSEERASLIKKELHGSITHLPEPSVPYRGTVFAMDPRNGYIDPHYRSDLDLFPAFHPPVPIDARHHEGRYHYEPTPIPPLHVPTALASSPTYPDLPFFRISPHRNPASASDSPFSPPHPYISPYMDYIRSLHSSPSLSMISAARGLSPTDVPHAGISPAEYYHQMALLAGQRSPYADIFPSPATAGAGANALHMEYLHAMESSRFSSPRLSARPSRKRTLSISPLSDHSFDLQTMIRNSPNSLVTILNNSRSSSSASGSYGHLAASAISPALNFAYQPTPVSLQQMHQQIMSRQHSIGSAFGHSPPLLHPAPTFPSQRTIPGIPSVLNPVQVSIGPSEAAQQNKPTSESAVSSTGDLLHNKRSKVKPEEDHPSPGAVCIQDQPDGMTLVKEEGVKDESKQEAEVVYETNCHWEGCSREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPREPGSHSQSRSPGQQTQGIHGEHKDLSNTTSKHEECLQVRSVKTEKPMSSQPSPGGKSSCSRQQSPISNYTNSGIELNLNSGGSIGDFSALDETPIMDSTISTATTGLGLHGRRVMTGTKWMEQIKVEKMKQVNGMLPRLNPVPPHRAPTLPPITGNGVQLNSNISLGGLAPVLPNRNDLSSMDITVLNMLNRRDSNTSTISSAYMSSRRSSGISPCFSSRRSSEASQFEGRVQNLSVAGSYDPISTDASRRSSETSQCDGLPTLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRMALLGDSRDCRLSPLPSVNVPRRCSDGGVGSYGRRHLLPNELQVNGMRRASDPVKMVSDNVSNTRVVRFNSLNNVIPPDVPPPMERRNLSLQNYTRNVYSPCPPSISENVALEAMIMEAEGNFDDEDLLPDDMVQYLNSRNQRLYETIETDALQNNAGERNGNNFEQSHVTSNVINEQFHSSEQTDLIENKNDLPIQWNEVSSGSAEYSPSRLKYGQRFPTQQNQPFGLYNNMMVQQQNVPKSGLSQQRGYQHHTQNNPQAPQQNLDLYNNSNVWSGQLGRGNQYIDDIERSSLGHSATGSLCNSAARGQKLTTNGLPMNTGQQNFGPSTHYSVQSANRAEVVQNENIINQEFMQQMTAEHLIYGMHLLGVTRSNQTTSGQNGNTTDGTRSFLSTTQNGGEQQPTLAKNFQSFVNSSGNSRQNLHRNNLPYLQEQIYDTNQHIFKVNSIKMEMQSHPQQHCANAQNFSGQLYDQTATYPQQIMKSGSEPGMEANCLLQESNNTNSSKLLSPGANHVTSTVDNIDNSLAGVQIAFAAIIDDGDHASLISGVLSPSIIQNLSRNSSRLTTPRASLTFPAIPVSTSNMAIGDMSSLLTSLAEESKFLAIMQ
The following text describes a protein:
Function:
Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.
Subcellular Localization:
Mitochondrion membrane; Peripheral membrane protein.
Sequence:
DLYTHRRREKNAGSRCVISMHSGTTTIIHDPKNPEHMKSFTFDLAYWSHSGFQRDKDGALISTGSNSDFAGQKDVFRDLGQGILDSAWQGYNATLLAYGQTGSGKSYSMIGYGADKGIIPNVCEELFKATENKEKNQQYQVTFSMLEIYNEEVRDLLSKTKKPRGLKVREDQHQGFYVDGLTSVPCDSYAHIERLMEQGIKARTTAATSMNATSSRSHMVITIQFKQVFLDGDLTKQSIINLVDLAGSERQKSSGSEGDRLREGSRVNLSLTTLGNVISALADVATGKRVLHIPYRDSVLTRLLQSALGGNSKTIMIAAISPADICYEETLSTLRYHLLAKNQARLQTIQITWEHQLEEARKEWEEQYSTITQERQMMKAFPYLFNVNEDPQLTGVLKHFIQAGSSNVGQAASNKMILQGLGISDKHATFTNIDGEVTVMPQSKCRIVVNGVPTVTKTKLQHLDRVILGSNSAYLYIGFPSERSNDDVTKFDYDFFQSELAAAEGVSVDKLGAGNNRDGKVDPSVLAVFQDYIKLIPLVAEANQMSKELRKPDLETGGLVWIWSKAKFINRKYLMEEIYRHFLDGENISVAQEDDPFWDPVEAIHLGSAHVWLQSLAYCMKLEEQAELLNSEGLEEAVVLINIIPCSSTGEACSEDDMVINPLELLGRRIDFQIQILKCLGVKWLKEDARRGIQIGYKIYDLQTTLYTKSVWKTVNAKIEETVHFVALNASHEFLNYLQKNALIVDLWGLQEGCAELNCTQKDLIKWEGYVMVDNMKTSPAQAATSNQMADVYLKLLKLEQETELLRNMNRALREENMLLKDSLRGCGTGQGQIITQLASHKDVPQMCSPRTSHDADFAKALKVFYQRMNIVRGQFLKLRHYRPPDDDQMLRPFTQRQSHLLKDIGELLEDSLWKLKNDVALIVKKKRESLVHTKYRGSSFP
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLAEEDDILTALVPLFIVLRPVGFVLFPAQSLKNCDKINYFSVFNLFTLALHLFFLLYGFKNNLNKFITAPDTLQKVYALVFIANAFGLMGVNLIWDKFENGKFLDLLRYFCNMDLKLRKNNIFLDYKTLQKRPAVVILFEWISYTYFNIDTAIIFVRIGKNIETVLLDFIFYQGLHAMQVAMTVKCLTLFLVIENIFDHLNSELNTGETTKQLVEKIRNFYHDTYDLTIRANKVIALQLIVPLCITFVMVVYHIYYQIKDSSLQTSVTVLVWLSTMLVKIVVVIVQIHRTTSAVFCFYFNEQSLFLQFQAKNIRKTLIKLTLNRTKSINVFFLQLLHEEVKITGASFFNIDVGLIGGYFGKALQYLLILYQTCD
The following text describes a protein:
Function:
RNA-binding protein which regulates transcription, splicing and RNA-editing. Limits the accumulation of double-stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs. Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress. Involved in the regulation of physiological processes including aging, fertility, growth and locomotion. Plays a role in maintaining localization of chromobox protein homolog hpl-2 to gene bodies, perhaps acting via binding to nascent RNA transcripts.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm under stress conditions.
Sequence:
MADETPKVKTEPAAEVKSPLDEVKEIRKEAELTQTGSDEKKTTDPEFITVQDPNGDEPIELPTVDGVVLMTTLQASFPGATGLKYKNPKTGANRAVQVDPSGLKLIAPADGWENKTFFVIVAPQSERVRALSSADATSAKRRKVGSSDDSDSDDGRDGRSGRKRAVERDSQPVDLIVLGVDFKTTDECFQKYFEDIGTVVFCEIKRKSDGNSKGFGFVRMSSVGEQNKVLAIPQHMIDGRRCDVKVPDGRSLQDKQGRPSISRIFVGRLTDKVDEHQLRKVFGDEAKSYIETAVVTDVFIPKPFRGFAFVTLSSAEAAERIVSKGSLTVNGLSVGLSIAQPREENNQSVGPDYGLPAGYRNRRERDRPDRRPIQNEAPLPMPFVRPPQDYSYRQQNSPLERRYWAPGDSRGPGW
The following text describes a protein:
Function:
Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGGEGDSSKPLTAVDVGEGEGGALVAVNVRCSNGSKFNVSTSLDSTVEAFKELVAQNSDVPANQQRLIYKGRILKDDQTLLSYGLQADHTVHMVRGFAPSSAPPPPSAPVNQTTDNTSNLGESLFGFNPLGGGSLFGAPPDLEQAQQQLAQNPNMVRDMMNSPAIQNLMNNPEFMRSIIMSNPQMRDLVDRNPELGHVLNDPSILRQTLEAARNPELMREMMRNTDRAMSNIESMPEGFNHLRRMYENVQEPLMNATTMSGNAGSNAASNPFAALLGNQGVTTTTATQGSDGSTNAETGTGNGIPNANPLPNPWGATAGQTNAPGRTNPGGDARSPGLGLADSPLGATPDASQLNQMLQNPAMSQMMQSMLSNPQYVNQLINLNPQLRSMLDSHPQLREMMQNPDLLRQFSSPEMMQQMMSLQQLLSSQNRNTTSQEPGQTGAAAAGAGNNGGMDLLMNLFGSLGAGGLSGTNQSSVPPEERFATQLQQLQEMGFYDSAENIRALLATNGNVNAAVERLLGSIGQ
The following text describes a protein:
Function:
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle.
Sequence:
MGRRAWTLQCTAFSLFCAWCAMNSVKAKRQFVNEWAAEIPGGPEAASAIAQELGYDLLGQIGSLENHYLFKHRNHPRRSRRSALHITKRLSDDDRQDTRMTATLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPSTWSSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRIADMSGRIQNEGRIVTWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKVVDSGEEQPTQEGLDENAQASQSPSGSGVGGRRDELAEGAPSEAMLRLLQSAFSKNSPSKQSPKKPPSAKPNIPYENFYEALERLNKPSQLKDSEDSLYNDYVDGFYNTKPYKHRDDRLLQALVDLLREEN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKPNLLKKTKLSSQKSKDKQLQNGDKEPLPSDVDAICVGTDATETSNDMLNCVMDCCPKVTQMSPEQGELEALGVLMLSEQHQQHNVNLQPCPPALRTFVPKTEPDHFPLNQTSFQVKTEPGIYEVLQRESTLTVEEKKERYKEVKLEMPEENLLCNSDLEETMASSSLIFPCPHCSVTFTDFTYLDKHFKWCHRSEYLSWVKNHKVYNCSKITSGMLSCTSCHYRFFSQSQLETHVRKAHLPTPKPTRKRFTCPQCDRSFDYIGNLQNHCRRCHSLSTVCKDGYISCAACGKSFAGVWGLGPHRCHDDEKILDTSEPLCTDRGYLCQDCGKNFSTLQSLKTHKRIHTGEKPCICGDCGHSFYDMGSLRQHRVIHTGIRPFKCPECNKEFARMGHLRCHLRTHTGERPYPCPQCGMRFSHRSTLRIHQQVHSKEKAFPCAICGKAFSALRYVKVHQRAHNSERILECRECTKTFTRADVLKKHLRIHSGERPYFCNICSKRFVRIQHLKNHMRTHTGEKPYRCEQCGSSYAQSGDLTKHMRKHTGEKPYACSDCERRFSSSGDLSKHRRSHTGHRPYKCLECGKSFILSQHLKLHKRTHTGERPYSCTQCLRTFTRSHHLSQHMEKHT
The following text describes a protein:
Function:
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MVEKKSPAEGWPVVNGDYIVGDPESPVAATTLASHIEDIPVEAGAAIAGPCKTENLGIEKMIANLISNPNIRFLILCGSEVQGHITGQSIEALHQNGVDPDKRNIIGATGAIPYIENIPDEGIERFQKQLEIVNLIDVEDADAIKAKVKECIEKDPGAFEEEAMIIKVEEGGEEEEGEEVKPVAPETALIEARMRNIQTQVKMIGSTNRMFAGMYSGKVQGIMIGLAFTLTLGILLLV
The following text describes a protein:
Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Sequence:
MERRLIMNGGKNLMSRVSPNPLPPKDIPSRPTVPKRIPTPPSFDESHHRLPSTQPPARRRRRFAATFVSPTADSDDLSSNSDRLVIADEEDVTPGQGQPPSTLSHQELLPTCSSPIGLAPTDDSTEGMIFYGTTECSPVITGSRPEGPIGKWIRTVGKPLGHVEVKIVDNENRVVPLNNRGQLCARGYLVFLGYYNNEQKIEEEVQNGWYYTGQ
The following text describes a protein:
Function:
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Sequence:
MALRTTLRRTSANARRQIWHPSLQIARNRFWCTDETSSHEVLRSFATAEPHFSKPDVFGFPSLTKSLKGPDAEFKSSYRGFNIEHYINLLHGGYNSFSKSDSQLCPNEVPFSSSPVFISSGYAAQPSSSLASKGCFDRLHFSIAVDSSGSEPEKEFDQDEQDKIVPVRSARLKETDWIQILLPKKLHPFAHLARLDRPIGTWLLAWPCFWSICLAAPAGSFPDLKLMSLFGLGAILLRGAGCTVNDLLDSDIDGKVERTRDRPLASGALTTYQGVGFLGCQLLLGLGVLLQLNDFSRILGASSLLLVGTYPLMKRWTFWPQAFLGLTFNWGALLGWAAVHGGLDPSVILPLYASGISWTLVYDTIYAHQDKEDDLKVGVLSTALRFGDSTKTWLAGFSAVCVSGLALAGFNADLGWPFYAGVIASAGHLAWQVSSVDIHSRADCNSKFVSNKWFGAIVCSAIVAGKLVTQ
The following text describes a protein:
Function:
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
DLRAAAVETGLSSAPSTAAPGKPEHAPQASGRVRPSQPSLFHLVLREGKMSESSSKSSQPLASKQKKDGTEKRGRGRPRKQPPVSPRTALVGSQKELSEVPTLKRPRGRPKGSKNKGAAKTRKTTTTLGRKPRGRPKKLEKEEEKGISQESSLEEQLPSGTGQL
The following text describes a protein:
Function:
Regulates arginine biosynthesis genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKKERLEKIKEILKKRNISSQKELMEALREEGIYVVQATLSRDLKELGVIRQSSDLGKRYIIPENAINVASLKDLFHRVVVSIDFAENLILVKTIPGNAQAVAFLLDNFLNVYDYFVGSVAGDDTILIVLRSKDKTQEALEKLEELRK