lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTNLKQKLKTAPKKPGCYLWKDSNGKVLYVGKASNIFNRVHQYFQKNNPYKTQLLSSQISDVDFFILKDENDALNLEAKLINQYQPRFNLVLKQNNGYLYFYITKAKKPTLELARKYQIKTTKCFGPFASSKFKLREIHDLLLKLFPLRKCAPHQKNHPCFYFQMGLCMGQCMQTDTKEKYQQVISNIEQFFNDPSVVINYLKAAEKKASDNQEFEKAQQFLTLQKAVLELTKTHHTTIIKQKSSHDFIGYVFQNNVLAITIFCYEKGELTDKEQAVFTLEQTDIVEVESAIITFIYHHYKTTPLPSKITVSLDETNLKLISDSLKIGVFKPKNGNEKLILQTVIDNAKHALATKWLKFTSNYDKTQLHKDLAQLLNTDYIHSLEIIDVSFYDQNHVVGCMLRFEDGKKIKHLSRRYNINSLKKGDTNHIALLVYRRILSAMQTKANLPFSDLLIIDGGKAQIKSVKQVFSLFSNVKPPIIIGLVKNKNHQTDHIMLSDFQVKKIAINSPLFHYLATIQTEVDGFAKRSAFNKLSNHQLQNPLLQIPGVGKITAQILFDNFQTLNNIKLASVNELSQFIKKPLAQKIKTYFAKQTD
The following text describes a protein:
Function:
Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MRTVRQRWATGWGRALHTSGSAPAGSSAESALLPEMGQLDPKVAAAPRRKYLSAKYRVVGKLFQQAENGGYLAYRKPAALENPYLDVQARPRVDGATGQIVYQGTPRLSVTRLLTKQWCELRTAYDLYSNMPLFESKAMRIGKRAHRKLENKLHGASDAAATQALERLQLAVPVDPLHRLAADWAGAIDRMCTLFQKGEARELLCHGYISADHGAFVEGPVREDSDVLVSGVIDHLVLTQRGGGSPLSALQPERSLQFPSDMAELVPFLKDLGERRAAEWEVVVGDIKTRKYTQVPSQASVVETSRLQVMYYRRFLEDLGADVDKAYEKLLTNAQRRGLDVDAPLAAGSAISVMEGIPQLGADMLRLVRGDPIGFGPFDSYNRYAAHDTYDFTQHAALLQDQPELQKYAVFFGQWKTPFNLRFLAARMAQLYGCIAPLLSNTLLIEYYMGGECFHVNTFKYDAAELRKHCEDSARFWFGKREIEPIEPTIRNVNAYCKFCDYKDICLWRKEAVLGWKSLGEELRGLP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAEGETEKEYDTPKAIEELRERFQGLTTALKESTKSPLEASLLFCQDFCQVLVEHAGRWKTDEDPLPLLEVYTIAILSFAKASSCLSSACENVPLLLEKLALSCAELLFLLPQHVPGALWEEFQSSMKVAHSLLQESGSSPLRLLTSLAQQDGVWANATLSSILSNQTPQTEHVHQYLELEGPTLLNMRIKHLIKVDSVDKAAVLAKVCSEFPGFEGQGNFKQTYLLCACMTKSQEQLMEEIALIDCKDALEMICNLESEGDEKGALCLCTTFLKRQLLQGEVYCAWELTLFWSKLLMRLESSADSFLSHSKEMALLCTSVCHVLFLIKVIQNEVGEVGLPVCVEMCIQALKMTSSDHKDSKSTICKTIYCLLPTDLEVKRACQLTEFLLQPTVESYYAVESLYNEPDQKSEEEGSLPVPNSLRCELLLALKTQWPFDPEFWDWKTLKRNCLALMGEEAAIVSSIDTLNDTDEQEMESALGKLPEYKDLEDFLLTTTNELNEITDEKEKNREAKKLREQGFVSARFRNWRAYMQYCVLCDKEFLGHRIVRHAQKHFKDGMYLCPICADSFESREILEPHVASHVKQSCKERLAAMKAARKVAKPPHSPKSPSKISKLAVKAHMSPGRGESQIAGQLGAPIKMEQPVSDSQISQDCFCPVKNCSKAFKFFRNLMAHVRSHKDDEEAMRFLEIQKQKVVCQYCRRQFVNVRHLNDHLQMHCGSKPYICIQLDCKASFNSNSELLMHRKMHSEFKAQCMFPNCGQVFSEAYLLYDHEAQHYLTYTCQTDNCGKIFYSQSEFLSHQNYHNLNYAVAGQASAAPPEAQPPPPPPPMTLSKEDAPSVAFSHEKNYSDVYVSESSKANAWGSIEMAKEAVSMKVKHSIENMLNSMAGPEIKEPEKCYTPLTNPTPTPVDVNLQPEAQHVHHNIPGQGDIPQVYPVPTAEKPAVSLRKNLPSDGLNDEFPNVIPQIISPSQIKMEVPCSLQGYPCSTSALVPAGSEENLHCCPSTDCSRAYSTNKSLSRHVKKQHPEIFEDWKLAKKYNKVAKITAKKGNRPSTQPGILCNKPGVQQMDYSAECSTPPSQCYPGSMEPVPITPMVNPTLYPPWGCPNNQNVMMPADMPQSWSSPPMNNCYPDAFHMNEYPTRSYPHWQPDPYQTTMPHPSDRDHPVAAVHGSAMLQAPSDSSLMSQYVSSSLMLDNGGQMHNGGHQYGLMQPDGTGENVDARKSAANMTGHFDSGNSISTIDSLPEGGYHTPYAPSESSCLTQCSSVDIPIKCLSPEAPVPPKPPNEMIKTENVPMPVYEQMESSVDGVMSPHSVAHSEFHGDDDCPNVDFEANPSDEKGGDSDAQRGKRNRLSKRTKWPAIIKDGKVICRRCFREFTSTKSLGGHLSKRSQCRPLDEVDLTADLPTSFLDFLNDPHVPDANGAIYNMPNGDFSQESCGLTTLTSSVMLKQEPHSTNIMDHSSSVSVSQENQQENATEMAYPTIVGPYQEDNLMEMSHAFQKMDLIEAAQEKMRKAMLSQKSVRKREPASETEKSKPPNKKEEKPTEKMPKPFKCDQADCDFSFMTKEALFKHLSKMHDYSSEMIEELKRTPSKLSPYPCQICAKTFTRTTGLRIHYEKVHRLSKAEMLKLKINARNRRAFRLNKDETTNNGPNIEPNSSATTNSKPAMPLIKQEPLDVAIAPQPEETKPPNIPEIPLGDEIKQTSTPEVVTVTRLPSPVSNVTEKAPVEGPQLAVKAPEKPKLELKKRPDTKVISSLKEKLSPVGKTKAQQEKSSLPQSRAKEPKSSNESTLSSPERPSSSKSTPTKEKKEKVQKRVSLKMSDTDNAYSPYRPYRCVHEGCTAAFTIQHNLILHYRAMHQASLPPNEIDSDAENTSVNNVQESVELPMGKDNEVRCQVKNCSRVFMGITRLVQHYLLLHKFSRDKATSMMASMTIGTFNCDRTECALPFDSVDKYIEHIKNYHKEIAISESGSVDPTFRCEYDGCDRVYTTKSNLLRHLIKKHDYVYDPKATDGRRTKSIGLFPGVNNGKENVENKLKAKKKNTKKKDAKPAEHWTSFGKPTLKSHEEASAMCTKKSSLQYPCMIVGCDAVERAERSIFKHYTTHGLTEKYIEDQRSQFIFCKKYSRSRFKEAEKTEAVSASSSEETEPDDGEKQCEQKTEEPVADKVGQEDGKLSNDDGAESHASTVTEGGIKRGRPRKPAHPTPACPQRIQTLRNRSTVNNSRENSNPGTPADQEQRDDGATPGSFKPLGLEDSFLKFLETSESTNPSKRKLNEKPSCEVPCKRQQTHRAKASAKSKTSDEIRGGENPVDFKNPLHLKSGNNVKIVIDKSLSDGADLVLKQLQHMKPIVMVKRWLYSGS
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It displays no activity in the presence of NAD.
Sequence:
METYAVFGNPIAHSKSPFIHQQFAQQLNIEHPYGRVLAPINDFINTLNAFFSAGGKGANVTVPFKEEAFARADELTERAALAGAVNTLMRLEDGRLLGDNTDGVGLLSDLERLSFIRPGLRILLIGAGGASRGVLLPLLSLDCAVTITNRTVSRAEELAKLFAHTGSIQALSMDELEGHEFDLIINATSSGISGDIPAIPSSLIHPGIYCYDMFYQKGKTPFLAWCEQRGSKRNADGLGMLVAQAAHAFLLWHGVLPDVEPVIKQLQEELSA
The following text describes a protein:
Function:
Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.
Subcellular Localization:
Cytoplasm, Stress granule. Nucleus, nucleolus.
Sequence:
MRKNRSSTIQQFIKAPDQKENNKNTELSPEDLELGKLSDNEFRAALIKKLNEVERKIEKQAEFWSYFTKEIEIIKKNQTELLEMKNTMDQIKQNTDSLNARVDNIEEQISIIEDRQAEWLQTEEERELRIKTNEENLQEIMDSMRSKNIRIIGIPENMEKRNGEEGVLNEIMEEHFPNVGINGEMCVEEGFRSPRFLNVKRPTSRHIIVKLANRNDKERILREVRKKKRTTYKGAPIRLSAHFPTETIQARREWSDIFKALKDKNLQPRILYPARISFTYEGEIKSFPDKQKLREFVTKSPPLQEILKKALILEKRKKGERGHNPQTRETDG
The following text describes a protein:
Function:
Transporter involved in exchange reactions through membranes. Has a low uniporter activity. Specifically mediates the transport of S-adenosylmethionine (SAM) and its closest analogs. Probably involved in the uptake of SAM in exchange for S-adenosylhomocysteine (SAHC), which is produced from SAM in the mitochondrial matrix and plastidial stroma by methyltransferase activities.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein. Note=Detected in chloroplast envelope, but not in thylakoid membranes or in chloroplast stroma. According to another report, localization is restricted to the mitochondria.
Sequence:
MAPLTLSVDVKSSSATSHDVSKRVMQSSQLKINKGFFASVNTQEDKPFDFFRTLFEGFIAGGTAGVVVETALYPIDTIKTRLQAARGGGKIVLKGLYSGLAGNIAGVLPASALFVGVYEPTKQKLLKTFPDHLSAVAHLTAGAIGGLAASLIRVPTEVVKQRMQTGQFTSAPSAVRMIASKEGFRGLYAGYRSFLLRDLPFDAIQFCIYEQLCLGYKKAARRELSDPENALIGAFAGALTGAVTTPLDVIKTRLMVQGSAKQYQGIVDCVQTIVREEGAPALLKGIGPRVLWIGIGGSIFFGVLESTKRTLAQRRPNTVKETKEE
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLRAPASRKALKAEKEQQAQAAVEKKPEHTRSTGIDLSPIVEPRQGFIVLAWSLLWMVVLLAVGLYLVAVGGNMLPFDGSNLSASAKPTAVQDSAPMSLSECAAKAASLIANNKPSLPALPCLTHQQFERLLIVTFDSDTLVPKTQSAGSGVLPFHQLPSVQSSVNSNGFLYNIEPQPIHSSRDAVVSALTGVHARMIESLQRIVVPSFPHDSVVAQMADSLTARRSVIPTSDEEEEDEPKPSVAYVPECYGDGGWSTLFPSAFFDCESTNITPRVLHRLRSSTFSLLAVHLTLRHLDQKSGLDGFLHTALPLIDEQTLAVVIHHSPQGSYALLHSGRFDRQVKDNNIKKLTQSYKDKSNPSQIALEDIAPTLSVLFGLPIPVSNEGVVIPEMIVHGSNGQYYQKLTSLRVSLRHNAEQLNTLTRRKLSDEKQETYKDVLALGATTSQIYRSADHPVHFKAMHEDCKMDYRMSKILSKLVQTTYTEIKAVLIVLGFIVIIGATTLALIQTVVYFNDDPKIPDEVVLMAVSIGSLGGFFGGLTKSIDMLIPAYSINIHPYHEGIFCGSMLLILVVSLLRIKDLIFPNPLSAVPIAGAPSLPFGIFSFNGLLAGVTLALLFASPFAHNLGLGLTERDVVLYGLQVFALLLFINAFFVSNTEHRDSLVKTTLLFIVLLRIGLVFDFETSPLFSNPSHQISTMVIPAAVAAINFVLAFVFTYVVRRTMYSSDNLHSSGAVISGVLVPFGLFVSAFYWMLETLHIFPGVMTLKISDTLNFVQYWTCKLGFMSTSVTSMYVWGTDPSTIGMEVTDNNATKRSQVFSPEEAKTEKTSGKTIFFRGIANGIGSSYFSFFLSVYMALNYLQVSVGSAALTVSILQICALLEMYHFWRDKAEAASWCTLFKFSSSSKQGKSASRSSRGPFKPAIGGTPASPRSSVNSNSPRTSVVSDSSDAQDVSRSLRAVFADPYLTTAFMGILTLLIRYVAIASAQHSSYELLSRQLPSDASLGFGGVKIARSTSVKTSMALYLEMAASTAVMIARVYGPNLILGSLAPALFVLWKRPCLRGGESRLLRELSFALTVRFGVIAGVLLLGEIFGLMVSASTVSGTGNKLDILNAWDTQAQVLVVRAMGTMIEGLAAVISVFVVWMAMNGYAGFQRKMKKFGILE
The following text describes a protein:
Function:
Important role in determination of the surface properties of the casein micelles.
Subcellular Localization:
Secreted.
Sequence:
MKVFILACLVALALAREKDAFTVSSETGSISSEESVEHINEKLQKVKLMGQVQSEDVLQNKFHSGIQSEPQAIPYAQTISCSPIPQNIQPIAQPPVVPTVGPIISPELESFLKAKATVLPKHKQMPFLNSETVLRLFNSQIPSLDLANLHLPQSPAQLQAQIVQAFPQTPAVVSSQPQLSHPQSKSQYLVQQLAPLFQQGMPVQDLLQYLDLLLNPTLQFLATQQLHSTSV
The following text describes a protein:
Function:
Aldehyde decarbonylase involved in the conversion of aldehydes to alkanes. Core component of a very-long-chain alkane synthesis complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGAAFLSSWPWDNLGAYKYVLYAPLVGKAVAGRAWERASPDHWLLLLLVLFGVRALTYQLWSSFSNMLFATRRRRIVRDGVDFGQIDREWDWDNFLILQVHMAAAAFYAFPSLRHLPLWDARGLAVAALLHVAATEPLFYAAHRAFHRGHLFSCYHLQHHSAKVPQPFTAGFATPLEQLVLGALMAVPLAAACAAGHGSVALAFAYVLGFDNLRAMGHCNVEVFPGGLFQSLPVLKYLIYTPTYHTIHHTKEDANFCLFMPLFDLIGGTLDAQSWEMQKKTSAGVDEVPEFVFLAHVVDVMQSLHVPFVLRTFASTPFSVQPFLLPMWPFAFLVMLMMWAWSKTFVISCYRLRGRLHQMWAVPRYGFHYFLPFAKDGINNQIELAILRADKMGAKVVSLAALNKNEALNGGGTLFVNKHPGLRVRVVHGNTLTAAVILNEIPQGTTEVFMTGATSKLGRAIALYLCRKKVRVMMMTLSTERFQKIQREATPEHQQYLVQVTKYRSAQHCKTWIVGKWLSPREQRWAPPGTHFHQFVVPPIIGFRRDCTYGKLAAMRLPKDVQGLGACEYSLERGVVHACHAGGVVHFLEGYTHHEVGAIDVDRIDVVWEAALRHGLRPV
The following text describes a protein:
Function:
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
Sequence:
MDLFLRCFLLLGALSVVACYAADEITYMPGLPKQPSFRQYSGFLNVSDGKHLHYWFVESQKDPSTNPLVLWLNGGPGCSSLDGLLTEHGPFLIQQDGVTLEYNDYSWNKIANVLYIEAPAGVGFSYSDDKNYKTNDTEVAHNNYLALKQFFQLYPQFSKNDFYITGESYGGVYVPSLAVEVSQDSSINLKGIAVGNGLSSYENNDNSLIFFAYYHGILGSQLWSGLQTYCCTKGSCQFYNNPDGNCSLLVQEAMHDVYSTGLNIYNLYESCPGGAPGEVKDNGDHIIVYHPGMISPQLLKHWNKKLLSLSLVQKPIRLDPPCVNSTASRIFLNNGLVRLALHIPPSVQQWEVCSYDVYSTYGRIYQSMKDHYLKLLSTMKYRILVYNGDVDMACNFLGDQWFVDSLQQKLQVQRRPWLYNEGGQQQIGGFVKEFSNLSFLTIKGAGHMVPTDKPNAAFIMFSRFLQNEPF
The following text describes a protein:
Function:
Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level. Catabolism of gibberellins (GAs) plays a central role in plant development. Controls the level of bioactive GAs in the shoot apical meristem, which regulates the vegetative to reproductive phase transition. In vitro, converts GA1, GA4, GA9, GA20, and GA44 to the corresponding 2-beta-hydroxylated products GA8, GA34, GA51, GA29, and GA98, respectively.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing GA2OX1 exhibit extremely dwarf phenotype and are unable to achieve phase transition from vegetative to reproductive growth.
Sequence:
MVVPSATTPARQETVVAAAPPAAAASGVVGGGGGVTIATVDMSAERGAVARQVATACAAHGFFRCVGHGVPAAAPVAARLDAATAAFFAMAPAEKQRAGPASPLGYGCRSIGFNGDVGELEYLLLHANPAAVAHRARTIDAMDPSRFSAIVNEYIEAMKKLACEILDLLGEGLGLKDPRYFSKLTTNADSDCLLRINHYPPSCNIHKLDHDDQCNIKSLVSTKASNGGNLMAGGRIGFGEHSDPQILSLLRANDVEGLQVFVPDHEGKEMWVQVPSDPSAIFVNVGDVLQALTNGRLISIRHRVIATACRPRLSTIYFASPPLHARISALPETITASSPRRYRSFTWAEYKTTMYSLRLSHSRLELFKIDDDDSDNASEGKA
The following text describes a protein:
Function:
Capsid protein that self-assembles to form an icosahedral capsid, about 54 nm in diameter.
Subcellular Localization:
Virion. Host cytoplasm. Note=Capsid.
Sequence:
MIVTPASIKALMTSWRKDFQGGLEDAPSQYNKIAMVVNSSTRSNTYGWLGKFPTLKEWVGKRTIQQMEAHGYSIANKTFEGTVGISRDDFEDDNLGIYAPIFQEMGRSAAVQPDELIFKLLKDGFTQPCYDGQNFFDKEHPVYPNVDGTGSAVNTSNIVEQDSFSGLPFYLLDCSRAVKPLIFQERRKPELVARTRIDDDHVFMDNEFLFGASTRRAAGYGFWQMAVAVKGDLTLDNLWKGWQLMRSFEGDGGKKLGLKPTHIVVPVGLEKAAEQLLNRELFADGNTTVSNEMKGKLQLVVADYL
The following text describes a protein:
Function:
Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted into the lumen of the colon following cleavage of the GPI-anchor.
Sequence:
MRGVFIAGVIAAFAITVVDSLNCTQCYTYNSTCDGQATECNEQSFSCVESSINSTLGGFLHVYQNKFCSASNCTENSTEVAFTVHLFDDQRYHFASQCCQGESCNATHSESGTQNVTDMQCMSCYGHNKTLCEEKPQKCYEGEQCVFIIAEMVNGSGRVELKGCSDISNSTCQFLSPGNTTVGEFVFKSVECTQPTEYTNSTTTIPPITNTSLTSVTRPGIKTSPASVTPQASMGTKASFTSSIFGSLLLLKLLF
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MARERYLEQLDLLRESVSSLGEMAEFVFSDSMDAVINLDIELAKKTLALEPKMDRLEEGIEVSICDLLALQQPMASDLRLVVSALKIAADLRRILGLSINIAKIPGKIEGGHVKPLIDTRKMAYIAGDMLKNSLRAFETQDPELARATAARDDEVDKLFYSVWVELIEMMAKDTDIISKATYLLFLIRYLERIADHCCNICESVVYLTTAERVKLN
The following text describes a protein:
Function:
Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Fimbrium.
Sequence:
MRRVLFSCFCGLLWSSSGWAVDPLGTININLHGNVVDFSCTVNTADIDKTVDLGRWPTTQLLNAGDTTALVPFSLRLEGCPPGSVAILFTGTPASDTNLLALDDPAMAQTVAIELRNSDRSRLALGEASPTEEVDANGNVTLNFFANYRALASGVRPGVAKADAIFMINYN
The following text describes a protein:
Function:
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRIRYGWELALAALLVIEIVAFGAINPRMLDLNMLLFSTSDFICIGIVALPLTMVIVSGGIDISFGSTIGLCAIALGVLFQSGVPMPLAILLTLLLGALCGLINAGLIIYTKVNPLVITLGTLYLFAGSALLLSGMAGATGYEGIGGFPMAFTDFANLDVLGLPVPLIIFLICLLVFWLWLHKTHAGRNVFLIGQSPRVALYSAIPVNRTLCALYAMTGLASAVAAVLLVSYFGSARSDLGASFLMPAITAVVLGGANIYGGSGSIIGTAIAVLLVGYLQQGLQMAGVPNQVSSALSGALLIVVVVGRSVSLHRQQIKEWLARRANNPLP
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MAPTTYAVPPRPASLHFLLESSTSKNGVPSLDLRWEPFQRHIESFLNAIDAYTQAARTEIVARATDHTAAVRDLKADKEEMERGIQLQRESEGEMLATLEAERHVVADLNASLSHLQSSLTKIKEKSSALDAELQSERKEVKAMQAEKERQTNVLNNMRERDTTELKQLEEALGWRVEGIKQDQLLMRFTLIDPEDPAREFSIIVDVSKQVYSVPNCDPPIPSLPDLVRQLNFDRDLFAFIKRVRIAFRALIPNPPNPSTKFDDLTGPSRSR
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MVLLSNDVFIQELNKLCGPVEGKKKTSIWITMKRVKRNDIKTLTSNKDAGDKKNTKKVNKNDNKGNKEYMCLIRATDGKNKKISTHVYDNVISFTQNINSIIKC
The following text describes a protein:
Function:
Carboxypeptidase that cleaves terminal D-alanine from peptidoglycan in the mycobacterial cell wall. May cleave L-Lys-D-Ala and/or D-Ala-D-Ala peptide bonds. Exerts important effects on mycobacterial cell morphology and cell division.
Miscellaneous:
MISCELLANEOUS: Overexpression in M.smegmatis leads to elongated cells and promotes the formation of increased numbers of Z-rings.
Sequence:
MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSAAPPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSRRSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGAVDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGPAGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MSQPTSPSNPASTHTGAQDEGKQTNIELVQVLQGHSDRAWSVAWHLTRPILASSSTDKQLRLYQYHLRPNPLDAKTPKLEFQYIDSIPSAHTRTVRSIDWSPKGDLLASGSFDSTASIWTNHNFDRRLDQADALDSEDEPGRAGSPILDGEGEGEESWECLMSLEGHESEVKGVAWNRNGNLLATCSRDKSVWIWEILVGNESQDHQNVIQDDEGYEVISVLMEHEQDVKSVCWSPVEDLLCSTSYDNNIHLYAEDVTADGDFTLLHRLKGHQSTVWDSSFSPCGEFLASCSDDLSIRIWHREKLPQGGVEGRDGGLTGGWRIGRSERERWTCISVLSGYHSRTIYSIDWTFAQLPQHTDSQSLGMIVTCGGDGIINLLKLSKGVPVSGLDSSSAQPDVVLLAQRKKGHGTSDINDVVWCKLKAPTLSSSNPEQTDWRTGVHHLFASSGDDGSVRVWRITEN
The following text describes a protein:
Function:
Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localized in the acrosome in germ cells throughout spermiogenesis, it is also present in the manchette of elongating spermatids.
Sequence:
MPVSKCPKKSESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWKDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVKILDPDGVLAEALAMFRKTEEGD
The following text describes a protein:
Function:
May have a role in phototransduction. Catalyzes the conversion of GTP to cGMP, a common second messenger that is utilized in a wide variety of cells and signal transduction pathways. A second subunit is required for enzyme activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MACPFFRRADSLTRQPSVIAEPGGHWALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCANYDYLADIQELLLKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTETCYFLESFRNPALDSELPLVEHINVSMKTISEGGDA
The following text describes a protein:
Function:
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Secreted.
Sequence:
MLLHSLLVLMGLLVLSKGQEDGGTDGNKTEKPCDDFTDLNLSHCFMGTSLYVRLLLYTRSNLDCGRELNHHHLSSQPLLNLNNPTAFVIHGYRPTGAPPIWIHHIVHLLAEQDDMNIIVVDWNRGAANFNYFTAVSYTREAAQNLTGFILTMQEEGAPLSSVHLIGVSLGAHLAGFVGANLKGMLGRITGLDPAGPMFTRAKPEERLDPSDAMFVDVLHTDMDSFGLRGSHGHIDFYANGGADQPGCPKTIFAGELLPAHSLLFFSFNLTKVPLYGLSGKSYFVCDHQRSVFLYLCALNRTCHLTGYPCSSYNHFLDGQCLQCEVFKPATCPVLGYNMSLWRDTLIRLGQTKVYFSTTASLPYKKLSYRVDMVTWNQYLRWGVVYFRLHSGRNFTEARVDHKLLRFEQYTSTRLLAQFDEDIQNIQKISMRISTGNIIGPRYKMRLIRIRFTPLDHPERPLMCRFDAIMEENMEVSFRPLPCNSHL
The following text describes a protein:
Function:
Involved in biosynthesis of legionaminic acid (5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the conversion of GDP-N,N'-diacetylbacillosamine (Bac2Ac4Ac) into 2,4-diacetamido-2,4,6-trideoxymannose and GDP. It can also use UDP-N,N'-diacetylbacillosamine however it generates small quantities of 2,4-diacetamido-2,4,6-trideoxymannose.
Sequence:
MSKRKICIVSATRAEWYLLRNLCHEIQNDKDLSLQIIATGAHLSPEFGLTYKEIEKEFKITKKIPILLANDDKISLCKSMSLAFSAFSDAFEDLKPDMVVILGDRYEMLSVASVCLLMHIPLVHLCGGELTLGAIDDSIRHSISKMSHLHFVSHEIYKKRLLQLGEEEKRVFNIGSLASTIIKNMNFLNKKDLEKALEMKLDKELYLITYHPLTLNVKNTQKEIKTLLKKLDTLKNASLIFTKANADENGLLINEILQNYCQKNSHKAKLFDNLGSQKYLSLMKIAKAMIGNSSSGISESPFFKTPCINIGDRQKGRLRTQNIIDSEINDLDQAFEKLESKEFKQNLKNFKNPYDNGKNPNKIIKTCLKNVNLDTILHKNFIDL
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. Cgi121 is not required for tRNA modification (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MTLPLETIRLPHLPSALPVHIALYRDVNNSPFLRQQLLSGNADFEYAFIDASMVFSRSHILSAIFRAVNDHLNGRLKSRNVHSEIVFSLSPANNIADSFRKFGITDSTTDLLVVKVSVTPDVTHASVATHLQQYIEGSPVPFADETLSEISDISKIKKAYKLGTLGSRDDEKRRLELSLIGAIALRGAT
The following text describes a protein:
Function:
In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion.
Sequence:
MMAKKPPKPAPRRIFQERLKITALPLYFEGFLLIKRSGYREYEHYWTELRGTTLFFYTDKKSIIYVDKLDIVDLTCLTEQNSTEKNCAKFTLVLPKEEVQLKTENTESGEEWRGFILTVTELSVPQNVSLLPGQVIKLHEVLEREKKRRIETEQSTSVEKEKEPTEDYVDVLNPMPACFYTVSRKEATEMLQKNPSLGNMILRPGSDSRNYSITIRQEIDIPRIKHYKVMSVGQNYTIELEKPVTLPNLFSVIDYFVKETRGNLRPFICSTDENTGQEPSMEGRSEKLKKNPHIA
The following text describes a protein:
Function:
Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNHNTSFQQQLLQQLHQPGGSNPGGVGATGAGNNSPSYPEASLMGSKFWQKQMQLAQLSRQTGPTSHGYARAAAINSRQQHGRDGAQVDADKDQGPSQLTLVDLAVQTVQQDLVEQQQATAASTPQRGYTNQQKKDQLEEERQMTLMQQEKHQYWADLDMSGQGLMCLSPPLFRSYEFLLKLYINHNKLTTLPPAIRSLRQLRVLDVSSNMLTKLPPEIGMLHNLRYLFAFDNYLSTLPHQVGQLYQLEVIGLEGNPINQPIKEKLAQGGTKELVAELRESAPMPAAPKPREWIVLEEAGGRGGAATAAAATEGESGSTVATATAGANAAAAGASASSDTFTVMSYNTLCDKYTTVQMHGYTPLWALGWKHRSETLLKEVIGYDSDILCFQEVDGASFEDFWSPKLHQLGYAGLYHPKTRARTMSKEKDAKRVDGCAIFYKTKSFCLIEKLSLDFSSLALKNNDFKKTADTYNRVLNKDNIALIALLEHVTTGQKIIVTNTHLHWDPAFNDVKLIQVALLLDEVEKFAERVAKDSNRVSARNQDGNNVKYESGKKLPLVICGDFNSTTDSGVYSLFSQGTVTNHKDMSGRAYGKFTDEGMNHGFTLKSAYSNIGELAFTNYTPNFVDVIDYVWYSSNALSVRGLLGGIDPDYTSNMVGFPSVHYPSDHISLLAEFSFKKQKGGDGQPKKALDFGNSGSHSGSRKT