lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Promotes clustering of HT2RC at the cell surface.
Subcellular Localization:
Apical cell membrane. Cell junction, tight junction. Cell projection, dendrite. Postsynaptic density. Synapse, synaptosome.
Sequence:
MLETIDTHRALQAVERLQVKLRERGDTSNEEKLSLLKSVLQSPLFNQILNLQICLPQSRDQVNIAPLASSPGEILQLSHHGSSLPNVGSSFQNESYLLAQPNGSLSSGLGAGIQSVTPQINGKFTSDEFELLIRNMAQGRLVETIELVKPSNGGLGFSVVGLKSEYRGELGIFVQEIQDGSVAQRDGRLQEADQILAINGQALDQTITHQQAIGILQQAKDIVQLVVARGSLPQLISPIISRSPSAASTVSAHSNPVHWQHVETIELVNDGSGLGFGIVGGKSTGVIVKTILPGGIADQNGRLCSGDHILKIGETDLSGMSSEQVAHVLRQCGNRVKLVIARGPIEEPAPPAVPPGTPLLSVPADGNTFDVTLTKNIQGLGITIAGYIGDKTSEPSGIFVKSITKGSAVEHDGRIQVGDQIIAVDGTNLQGFTNQQAVEVLRRTGQTVGLTLVRRGLKQEIHIRPHEDFSGAVEKDLIFQTMDIGTGKGSFQINSTDEEMPLHNKWQTILGTNYEVVVAHVNKFSESSGLGISLEATVGHHFIRSVLPEGPVGRCGKLFSGDELLEVNGISLLGENHKDVVNILKELPIKVTMVCCRTAPPAKHSVLEEIELDPDLGGLPGSSETEDTNLETPDMGQNTDEAQGSSLAMWETEVQQIELEKGSMGLGFSILDYQDPMDPANTVIVIRSLVPGGVAEEDGRLLPGDRLMFVNDINLENGSLEEAVQALKGAPMGTVGIGVAKPLPLSPEEGYVSAKEDSFFYTAQSFEEEGLTDSALFHAELALVDSSEADLAEESTFESQYSPDNDATFQSPVSALHGSTSVDDLKYNSSSTPKTVCKESCDASTIYRQLSDQNLYAMDLMQRRMESKSSVDVCVEESAGSCLVSPTTHSSKKQVEHENTNIWKQSSLTPELSHNEDLILKAPSDSIGKVSISVMSYNGPKFYIMVAKLSSNKDGSGMIVRSIIHGGSISRDGRIGVGDCILSINEEPTTNLTNAQARAMLRRHSLIGPDIKSSPAPADDQAPFYVISYVPAEQLEEYQASLSQQSGVMSLDVFPSHAVREIPELPEREEGEGEESELQNASYNNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSSGEVMRGIFIKHILEDSPAGKNGTLKTGDRIVEVDGINLRDASHEQAVEAIRRAGNPVVFMVQSIINRPRNLLMPYLQYNPFSKPPAFSSTNPFVDPLQFNTNKASSQSDSEPEKTSSCNLPLPPPSVSSGMSGEVVPQSCNKHMEDRDKEDGFGYSWKKISHRYGNLSGDLHMIELEKGKAGLGLSLAGNKDRSKMSVFVVGIDPNGAAGKDGRLQIADELLEINGQVLYGKTHQNASSIIKCAPSKVKIIFVRNKDAVHQMAVCPGNSTETSTTSSGTQHDEDQGGIGIAIGEEDTFNGVVIQSLTEHGAAGKDGRIKVGDQILAVDDEIVVGYPIEKFISLLKTSKPTVKLTVNSVEQEIQTAAQPQPLSYSTTSGEKNNIQQPAVVPPSESPEPESIKNTSRSSTPATLASDPTTCPIIPGCETTIDISKGRTGLGLSIVGGADTLLGAIIIHEVYEEGAASKDGRLWAGDQILEVNGIDLRNATHDEAINVLRQTPQKVRLTVYRDEAQYKEEDMYDVLSIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADLDGRLMQGDQILMVNGEDVRNANQEAVAALLKCSLGTVRLEVGRIKAGPFHSERRTSQSSQVCNCFGSLSSFSFPGSGLNAPESYENTLKKNSYSLGVSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVSISGTSTEGMTHSQAVSLLKNALGTIEIQVVAGGDVSVITSQQQDPPTSSLSFAGLTSSSIFQDDLGPPQYKTITLDRGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRLKRGDQIIAVNGQSLEGVTHEEAVSILKRTKGTVTLTVLS
The following text describes a protein:
Function:
Component of the CBC complex, which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus.
Sequence:
MASITRLDAVSPYLIRRFKNDLRALDAVKQSNCVYVGNLSFYTTEEQIYALFSKCGEIRRIIMGVDRFTKTPCGFCFVEYFENQDALDSLKYISRTSLDERIIRADLDHGYEEGRQYGRGASGGQVRDEMREEFDPGRGGYAKNRQPTSSRQLANYSGISSAPLGSSLELQSNPRYNRWKKN
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
Sequence:
MPAPVSSIKIIALAAIGILIVVFAILLAVFHNDLLAIAMPIAERIAKLPMSFLIALVLIAASSIPPLLGQDPLALLIGAVWGLNVGFWTVVCGIFIGETIAFMAYRYFLEQKAQEFREHHEEHYGTFVKIVEEGSYPLIWLIRLSFLPTHFTTVFFATLPELSYIGWAIAFWLSCFKYLVPVYAGYCIVHNKSSAANIVGIVLSIVVTLGTLAFLIVRYKAIKNSTLEDSTNSTSDVLNHLESQPTDSIDLRHLEQTSEQNETDNSERKHLLSHQH
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTLIPAHASVLLLFVVAATRYSHAADSEALNLAELTTVCSLIKIANDDGTDMPTAQLETDEIAAINEVNFSLADDYWTKAFPTDGIKTKAEAKGCEDVQSKDSCQEQWLAWQHIAHSLANKDKNNKAAKISPMQKTSSVGRAAALAAAAIAAEAATLQARFDAESRPALTDLKQKVLDDLKTAAYGAGKAETLAENKCPGAKGGNRAADCKVATAGNALCIVSVCLCAKNSGDQPNTDVCGATLTQDVTSWNEAGVKAAYRELEPHCLKMPSVKPTGANIRSLLAQLKGLYKTKGGGSGKSVILGTAGTNHDCRAEASAACVDMSASTLLAATGTATKIQWEEKLLEAANKLDAASEAATVAKVINTKLKALRAKADKLYSHLALTKPPIASQEILTPANKDQANNISKDCEAIVIPEECSLKSECEWNDKATEGEKKCKLNTTKVGQAKTQAGETKGNEQTATEKCTGKVEDVCKKEAGCKWEENKCKDSSFLPNKKLAPSMASAFVIW
The following text describes a protein:
Function:
Can phosphorylate the myelin basic protein in vitro. Required for endosperm development in embryos. Maybe involved in auxin and osmotic stress responses.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MFLKLFLLLSLVSFSHSDSSSTVSCPNGTDFHQLTTVFRYVSGFNSSWFSSNCSAVITHVVLPSRKLNGTVSWNPIRNLTRLRVLDLSNNSLDGSLPTWLWSMPGLVSVNLSRNRFGGSIRVIPVNGSVLSAVKELNLSFNRFKHAVNFTGFTNLTTLDLSHNSLGVLPLGLGSLSGLRHLDISRCKINGSVKPISGLKSLDYLDLSENSMNGSFPVDFPNLNHLQFLNLSANRFSGSVGFDKYRKFGKSAFLHGGDFVFNDSKIPYHHRIHRLPHRHPPPVRQRNVKTHRTNHTPLVIGLSSSLGALIIVIFAAAIILIRRRMKSARTKSRWAISNPTPLDFKMEKSGPFEFGTESGSSWVADIKEPTAAPVVMASKPLMNLTFKDLIVATSHFGTESVISDGTCGPLYRAVLPGDLHVAIKVLERIRDVDQNDAVTAFEALTRLKHPNLLTLSGYCIAGKEKLILYEFMANGDLHRWLHELPAGETNVEDWSADTWESHVGDSSPEKTNWLIRHRIAIGVARGLAYLHHVGTTHGHLVATNILLTETLEPRISDFGINNIARTGDDTNKNNVEFDVYSFGVILFELLTGKQGSDENVKSVRRLVKERRGEEALDSRLRLAAGESVNEMVESLRIGYFCTAETPVKRPTMQQVLGLLKDIRTVSR
The following text describes a protein:
Function:
Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'.
Subcellular Localization:
Nucleus.
Sequence:
MSGDTEEVTRLRKPRFSYEENQILIREVRAHYPMLYGAQSRRLSVAERRRVWEGIAAKINAITNWKRTAQEVQKRWNDFKRRTKEKLARVPHSTQSGTAEEAMTAEEETIFAILGPGVMPGSSHYGPVTHLGAMDFNPSGPGSSSPETSLSAPCAPIEAPLLLHPKESPSPTSQLHIVQLPHLTPSPDPSECPSPPPPGSGTPLLTPSGVAQHYDPTVAMLRAQQETAEAIRHLTYTLRQSMDRLTNVLAAILPLVPHQPPESPTPSGILGPVYYPTKTEPESEPCCPVTYEEENGEDGGEEEIQEVIAEPPRSPSPPPPNKRKRFGYLSQRKRRGRWKNL
The following text describes a protein:
Function:
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MRGVCIMINNLSELQKKDLKYVFHPCAQMKDFEENPPLVIKKGDGLYLIDENGNKYMDCISSWWVNLFGHCNKRINRIITEQVNNLEHVIFANFTHEPAAELCEELTKVLPKGINKFLFSDNGSSCIEMALKLSFQYHLQTGNPQKTKFISLENAYHGETIGALGVGDVDIFTETYRPLIKEGRKVKVPYIDSKLSNDEFVKLEDECIKELEDLIIKNHNEIACMIVEPMVQGAAGIKIYSAKFLKAARDLTKKYNIHLIDDEIAMGFGRTGKMFACEHAGIEPDMMCIAKGLSSGYYPIAMLCITTDIFNAFYADYKEGKSFLHSHTYSGNPLGCRIALEVLRIFKEENILKTINEKGTYLRNKMKEIFEDKSYIKDIRNIGLIGAIELKDNLLPNVRIGKEIYNFALKKGAFLRPIGNSVYFMPPYVITYEEIDKMLHVCKESIEELLKI
The following text describes a protein:
Function:
Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MLSVSRGPRRHEYRSEVETISRGPDLLLKATDETSSDGGSTSITKSVEDTGSKDKSSQSLVRTHHVLKIKLKKITNWSGCSGAALDDEPFYHGYMSREEAEKLVRTQGEFLLRKTESTKRGEVVVLSVFWDDTANHLVVEKANNGSSYYLKEFCFENISDLVRYHHQTRASVYKSGIKLFSWVIREEWQLYHEQINLGKKLGNGEFGEVFQGMLSVGIFTNDVEVAVKTMKGSKVTADERIKFLREANLMLKLNHKYVVRLYGVATQQEPIMIVMELCSGGSLKGRIEKDEPMSSQLKRKYCKQIAKGMRYLEKKQVIHRDLAARNVLLDKSDNCKISDFGLSLFGKLHKEKKLMKVPIRWLPPETLLKGIYSSKSDVWSFGVVMFEVFSREYPYSEVKVLKELRKKVAHENLRLKPPSDMPEEDMKVMQMCFEPVESRMSFLQLCKKYKELTSPLPTWNGIANKLIGIGTAV
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MDQRQENYKEVLIDWIYNLKYILNAYLNNKNVPPGHPIYILGNRIDIENNDIEDRINKIKQLVQDTIWITYRRNFPPLYQSNYISDTGWGCMLRVGQMAMAQMLKKHLKNHGDKRDEDYDNILLAFADNDSQECKEFIEFQNKKEKQKVHNFICPFSIQKIAYLAKKEFNLDPGEWYKPNYILFLLEELHNTIPIRASENLKLSVFNDSCLFLDQLMNRMFDIKFETDKDLEEQLEKTQLKSKNSLAIFVLTRIGLDEPNQKYLKVLDELMELPYFQGIVGGTPKRAFYILGRINDHYIYLDPHYVQEAENKGQIIENKMFNRTSYSCKYIHLLNQKHVDTSMGLSYYIRNKSELLQFWRDMKKIKQKSDDFFIFLSDTTPEYVDYSNQLEESSNKLNDDDVVFLQ
The following text describes a protein:
Function:
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Sequence:
MNWQMEAEKMAEKQEEPSNTQNGEPDNAEEGEGKKKKKLKREDLPPFEIVTGERLPAIFFKFQFRNVEYSSGRNKTFLCYVVETQGKESKTSRGYLEDEHAASHAEIAFFNTILPKCESSLRYNITWYVSSSPCVTCADRISETLRKNKNLRLTIMVGRLFMWEEPEMQAALKKMKSAGCKLRIMKPQDFEYVWQNFVEQEEGEEAKAFVPWEDIQENFQYYEEKLAEILQ
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Subcellular Localization:
Mitochondrion.
Sequence:
MLYASRFLTHSRKIRNASNVLRSEPAILVRWFSGGTCSSIGKGDDLIEIRRRGFNSSTDGLLSGVNRAVDPNIYIVGWVRGFNGNISRMAKTMGIPVVGSISNKSLQMHLIRGFATDAGLPPHQEIGMPSLSPTMTEGNIARWLKKEGDKISPGEVLCEVETDKATVEMECMEEGYLAKIVLGDGAKEIKVGQVIAITVEEEDDIAKFKGYEAPKGGAADGGKKSSASPPPMKEVAEKPASSPQPNVSKAVESSKAGDRIFSSPLAKKLAEDHNVPLQSIKGTGPDGRIVKADIEDYLASYGKEATTPFSEAATLDYTDLPHTQIRKVTASRLLLSKQTIPHYYLTVDTCVDKLMELRSQLNTLQEASGGKRISVNDLVIKAAALALRKVPQCNSSWTNDYIRQYHNVNINVAVQTDNGLYVPVVRDADKKGLSKIAEEIKHLAQKAKDNSLKSEDYEGGTFTVSNLGGPFGVKQFCAIINPPQSGILAVGSAEKRVIPGVGPDQFKYASFMPVTLSCDHRVIDGAIGAEWLKAFKGYIENPESMLL
The following text describes a protein:
Function:
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion.
Sequence:
MAAESDSSQLLENFSKLEVKTAKRKSSVNNASNDTLEYGLPLTEVYKLAFSFYKEKEGKAVHFSYEDKLQLVAFSQQVLHGPLSEAINKLPPLGTLDVVGKDRRLAWQKLGKLSTDQARAGFVELLSRRCPLFSAYVEAHRREKKEQERKAKEEEKRRLIEEEEKQKKEEEAKLIQEQLTKEEAIKRQIQQALNEQTFDQFRKYAEQQFPGDPEKQGALIRQLQDQHYIQYMQQLQAAQRGEQIKSVDEEKTDPDWNNQSDEINLNESSSNSLIPASMWTRSGIDEFKQTVAQAEGDGVVRVGHGETVTVRVPTHPHGTRLFWEFATDHYDIGFGVYFEFGTPTSDQVSVHVSESDDEDLEDIEEEIYDEEAIQTGDLEAGSVAVNGISKPLLTEIVPVYRRDCQSEVYAGSHQYPGQGVYLLKFDNSYSLWRSKTLYYRVYYTQ
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MSDTCGSKVIEFYQDSVVLITGASGFLGKVLLEKLLRCLEARKIYVLIRRKRDYSAQMRLEQILKSMLFDRVRNETKAAKALFDKIEAVEVNFERDDLGLEPALRDRLRQEVEVAFNLLASVNFNEALDQALETNVECTRRVLNLLSGARRIKSVIHVSTFYSNCNRTLIEEKIYDDIGFGGYDNIKSTFAKLQDDHKQFLSPVVLGTFPNSYTFSKKCAEVVVRDKFGHLPVGIFRPPIVTSSYREPVPGWVDNFNGPSGMVVPLSQGLYSAALLDPKKKPFIVPVDFCVNALLVCAHDVSKSSVTKSIPVYNYTDDCNLWTWDQVINGFFSGLGPIRKLVAKYFTGTITVNPVRYAICKRIMMFQAFCLDLIRTFSGKEKIMQRLFSKMVTLSEVLRFFCLNDWKMTNDNIRRISDEMSPLEAEMFPLDIRKIDWTEYYRNFVPGVIKYAVQPRSPRSPSIAERKLKESKVRETKKLNSGLFYLLWSSVFIIALKIFKNLFNKV
The following text describes a protein:
Function:
RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruits the MYO4-SHE3 complex to the ASH1 mRNA. Also recruits LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 4070 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm and is exported in an mRNA-dependent manner. The presence in the nucleus is essential for PUF6 and LOC1 to bind the ASH1 mRNA.
Sequence:
MSKDKDIKVTPGTCELVEQILALLSRYLSSYIHVLNKFISHLRRVATLRFERTTLIKFVKKLRFYNDCVLSYNASEFINEGKNELDPEADSFDKVILPIASMFVKCVETFDLLNYYLTQSLQKEILSKTLNEDLTLTAESILAIDDTYNHFVKFSQWMIESLRIGSNLLDLEVVQFAIKCADEDGTNIGETDNIFLQEILPVNSEEEFQTLSAAWHSILDGKLSALDEEFDVVATKWHDKFGKLKN
The following text describes a protein:
Function:
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKGKSVKSTEKSVGMPPKTPKTDNNAHVDNEFLILQVNDAVFPIGSYTHSFGLETYIQQKKVTNKESALEYLKANLSSQFLYTEMLSLKLTYESALQQDLKKILGVEEVIMLSTSPMELRLANQKLGNRFIKTLQAMNELDMGEFFNAYAQKTKDPTHATSYGVFAASLGIELKKALRHYLYAQTSNMVINCVKSVPLSQNDGQKILLSLQSPFNQLIEKTLELDESHLCTASVQNDIKAMQHESLYSRLYMS
The following text describes a protein:
Function:
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MATSVDQISKSLSTLGLQDLPVFREADIHHNPVDVYRSYISSELSKINGVDVSLIYPALETSISKDSADLNLPVPRLRVKGKPQELAQKWAEAFPKDLVEVTANGIFLRFNFNGPSLTKLILPIIWEQRENYGRNESGSGKVAVIEFSSPNIAKPFHAGHLRSTIIGSFLANLHESQGWKVHRVNYLGDWGKQFGLLAIGYKKYGDEDQLKSNPIRHLYDVYVKVNADATEEDEKIQKDKAEAESKGLPYTPPLSLHDKAREFFKRMEDGDEESLKVWARFRDLSITKLKDTYDRLNIHYDEYDGESQVSLELMNKMVDELRSLNLIEEDGGALLIDLSKHDKKLGKAIVQKRDGTTLYLTRDIGTAYKRYEKYKFDKSIYVVSSQQDMYFSQLFKIFELMGFDWAKKCVHINYGLVQGMSTRKGKAVFLDDIMEVAKEEMHKVMQKNEEKYAQVENPEEVADIVGKTAIRIQDSTGKRINNYAFDWSRMTSFEGDTGPYLQYAHSRLSSVRRNVNYTDEEIMGANLELLTEPDAYDLVRLLGQYPDVLKNAFRFQETSTVVTYLFKLTHAVSKLYDILWVRGRERDIQLARLALFGAAKQVLNNGMTLLGLTPLERM
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MNSIDASDRHVHIETAPPPSLLAVVLDTNPHAWAHLSSSISLSAALANILVFINAHLASGNANESRNGTNGDVEMNGAEDNKPYIAENPNKYRAFALVESAILKNFAKLLEETNESHLAATPTTLIGGAISMALSYINKSTILHAPTGASAEITSVAAMADTDNSTHLDRIALTSRILIVSVSGDLANQYIPVMNSIFAAQRKKIPIDILKLAGDTVLLQQASDATGGVYMKPERPEGLLQYLMMAYLPDATARKSLIIPRIQKAATTWIYTRSDKMPAVMLAWRESRTLTMFDPIRGFGVAPPTLPEVYAD
The following text describes a protein:
Function:
Catalyzes the stereospecific epoxidation of squalene at the terminal double bond to form (S)-2,3-epoxysqualene, the first oxygenation step in sterol biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Detected in the outer envelope of chloroplasts, which is termed the chloroplast endoplasmic reticulum and is continuous with the nuclear envelope.
Domain:
The histidine box motifs may contain the active site and/or be involved in metal ion binding.
Sequence:
MLVDRVENNEKQQQQMASSSDAMSDSSLSDDEIIEHVVHGKEPKSTYELSWVSNAIAWSGALVWPLMLTVPLLLSSMYSPISYRQVFPESWYVYDTLSNCAPKPLGLVLGILAVAVGQVFVWIFFYLFKFGYLGTDPRSIQSKGAREYIFREGLLTHIGQPEGFVLLIGYLAITWMLKLMPQSYYSFEGTIQYKELFMCLVLQDGIQYTMHVLEHIVSPAFYQMSHKPHHRFTNPRLFDAFNGSLMDTFCMIIIPLFVTANLVRHCNVWTYMAFGSSYACWLTLIHSEYVFPWDGIFRKLGLGTPADHHVHHKFFKFNYGHLFMWFDQLGGTYRDPSGFAPRVFRENV
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities. The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA. Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B. The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively. The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B. Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties. In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKPSHSDTPLMMPSVMKCGYLATAGLIGICTHLSYFRYGEHHLYPWRYVRFHLCLTMGVAALLYAKKPPQYTLCSMDLVKDVSLLMATYLVGLFASLLLYRTLFHPLRQIRGPWAAKISSFWLSFRLRRGPSFRILHELHEEYGPVVRVGPSEVSIIHPEAVRMIYGPNSRCSKNTFYDNGHPMMSLHSYRDRIAHDQRRRVWSAGFGDRALRGYEQRMRVYRQKLFQRLEARAVAESAINISQWFNFYSYDTMGDLAFARSFDMLDASRNHWAVDMLMHGMIGYRYLFPSWFFRLLATMPSLSSDWHKFIGFATDTMLRRVGEQVDVPDIFASLLAPLNGREPTEDERNMLMGDAMLIITAGSDTTATSLTSIVYELARHLDEVDKLRAELDPIEADSDGEYQHDTLAKLPHLNGFINETLRLHPPIPGVIPRKTPPEGIHVKDVFIPGNMTVFSPQWSMGRSEAAYIDPEIFNPERWYKHMDLVKDPSAFAPFSIGPYSCIGKPLALMNIRTTVARLIMSFDVRFPEGEDGIRWMDAADEHFAMGIHQMPVVLTRRH
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
Subcellular Localization:
Cytoplasm.
Sequence:
SKGEMMEREESEAESPSSWSPVQRERLFTCGTISDISGKKRKQGTVSETEAVTRVLEDKDVDDVAANAGPVKDGEEPSNKRVKPVSKGAGLASFMGPVKSTSLKRIGQSIQRSISFKTEARPLPPAPLRHRQKAASLPRRRNSQLWSETVESISEELPAKEIKRQEVIFELTQGEKQLIEDLNLAKKAYYEPMLKLDIMTESELGQIFGTLDSLIPLHEDLLNQLENLRGTKNCVAEVGPTLMNWFPCLEAYITYCCNQVAAKALLDHKKQDRKVDEFLRLCQESSFSRRLDLWNFLDLPRSRLVKYPLLLREILKSTAPDHPDHQHLQEAMELIQRVVSQVNSKTGEAECQFYRRGLYYLEDTQRVPEIQLSRYLYCHGDLKSNKGQKLHVFLFELVLVVTRPVSHSDVLQFQVYRQPIPVGDLVLEDLPDGEAGVGGSFRGAFASGNERAKNFFRVSSKGRSKGQAHSLQANDSFNKQQWVSCIRQAIVSFRDQQDPGPAPDSSLEDIADLSLDCDDKGGGDVEMTDT
The following text describes a protein:
Function:
Involved in cell shape control.
Subcellular Localization:
Cytoplasm.
Sequence:
MGLEHIPEENRVLIGQSRVKGHGVGADNELGAEIAEEDIDEVQGAIDSIPVHEVDAFLVISGLGGGTGSGGSPVIAKHLKRIYTEPVYGIGVLPGSDEGGIYTLNAARSFQTFVREVDNLLVFDNDAWRKSGESVQGGYDEINEEIVTRFGILFGAGEVEQGGDVAESVVDSSEIINTLAGGGVSTIGYASETVDNNSGGAGSGLLSRFTGDDDELEDTASTTNRITSLVRKAALGRLTLPCEIEGSERALLVTAGPPKYLNRKGIERGRKWLEDQTGSMEVRGGDYPVSNSDQVASVVLLSGVNDVPRIKELQEVAIEAQDNIDEIREESEDNLEELVEDDEDELEPLF
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
Miscellaneous:
MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome.
Sequence:
MFLTFSMCVNWIIVKMPNRSEELDRLLDKIINSPHRTEASKTLQEIENNQSYILNVQLKKLLRLHDDSFKNKCVSPINYMLEKYTPYMGHTEALQKEAELVDRDLRILEMTYQLIEKNRNSK
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MPDTAPTAARARLADARLYLCTDARRSQGDLPEFLDAVLAGGVDIVQLRDKGMEAAEELEHLAVFADACARHGKLLAVNDRADVAHAARADVLHLGQGDLPVPAARAILGDDVLIGRSTHAESEAAAAAAQEGVDYFCTGPCWPTPTKPGRHAPGLDLVRRTAALGTDRPWFAIGGIDLGNLDEVLEAGARRVVVVRAITAAEDPGAAAAEFARRLRQAPAHG
The following text describes a protein:
Function:
Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MPPKKKGKRGPSAKTKEKETVRVASEGVTEQTKDFYTVQIRDLEKRLERYQSKWDEICAKEQLKEAQYEQLSNDKKEIVSFLKRTLNQRMDEIADLNDQLLGLQQAKDAEKDAYESQLTQVRHELQDTKERLTSENMLLAGKLASLEEFRVQKEELMGKFAALEEKVKEQEQEHKEAMYILEKKVVLDKDRLKKEMVQRVSTVAAEFRRVSNNQMAETTKRAIRENVSISLQLDKMSDKSIELISENDLLKDRNSELTKQLEMLEENEKELVKNNLSNQKVIRMLTDKCQQQQEILTLLEHTQHALNELQSQHHNLKDESQQLKQKLVSLEDDLQRVTQEKEGLSRQLEEEKQRTLAVDMILSQAAAFLKDMLLTHSEDETEGMQLERRNKMLQQLQLLLDSSATLGLGSSLHEFETKQGHSLKSLKTNRQPVSPVLKGPGVTAHYRIGDLGLVPRQDVSNAVLSKTAMLSKITRLGPLRGTHGISKELLSWTQEEKQIKHSALPEISPGAPSKLLMAK
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted.
Sequence:
MSLSGFLTGILTGAAGIINTLSQDVTNGNSLWGTLQAPTFPPFLTNNPLPNGFPWGSLTAGGNNPYTSAPSTGVIRYYDFTVTRGTIAPDGYAKQVILVNGQFPGPAIEANWGDTFMIKVHNQITGPEEGTSFHWHGLLQKETPYMDGVPAVGQCPIAPGASFTYTFKADLYGTSWYHSHYSAQYAGGLVGPMIIHGPSNAPYDIDLGPVFLTDYYHKEYFSIVQDVMAGGGNGNPRPMSDNNLINGKMTFDCNTKAAGDNTKCYDNAGVSQFRFTTGKTHRLRLINAGAEGTQRFSIDGHKLVVIANDFVPIKPYTTNVVTLAVGQRADVLVTANAGRSNSAFWMRSSISTICSTAKQPNALAAIYYDRADTSKPPTSTAWNAPDPGTCTNDDLTITEPYYSLAAGTPSTTKNLDINFYVNETGTLLWELGGTSFRANYNNPVLLLADQGKFNYPTEWNVQNFGSNSSIRVIVNNPTPASHPMHLHGHNMQILHEGPGNWDGVSITRQSNPQRRDVQLVRPFGHMVWQITTDNPGVWPFHCHIAWHVSGGLYANILERPEDIKNNMLIPVEMAQTCTQWNAYTNRAVVDEIDSGV
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSSFVSQLSPSLFSILREQLEKKGFTISIPPHTVFQGRSPTVSCTVYQSGKIVVQGKGTQEFVEFFLEPEILQTFSSQNVQQDLRSRIGVDESGKGDFFGPLCTAGVYASSPQAIEALYKTSICDSKLIPDAKILSLAQNIRSLCACKVITLFPEKYNALYANFQNLNSLLAWTHATIIDNLAPHPAGAVFAISDQFASSERVLLQAVRKKCSDIELIQRHRAEQDVVVAAASILAREAFLSSIHALESQYQIRLLKGASGKVKQRAKEILHNKGQVVLEKVCKTHFKTFNEVLGSGNQ
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MKPLDFIELVSTQMFMPGKTRGCDFWAGLTTDMFCGEQWFMVTYRTSTMAITNSGSLNHQPTSTSSNNNSTTNALSLRISKVLATSQFDDPNFRQALDTLNSLTFQNPSSPHVDSENLGSKASEIDCLQSLKKGGLRRIVEQRIRNRSREFLNVFSELNDDLIDLQSHLDQMHECCDEIQENLKMANSATKYLLEHAEGLRKEDEAIAAKRVIVKAFLEKFTLNESEIQALTSREVTVNWSVFEAMEHCEQIRSDCATLLTGDSQSPKSETAGLDIMQATSKYLDKGYDKVLKWALFECRSGLIKPDEAQPEVSPLMKRAINRLKRRPESLEEVINTLTAARSSSLSGLFLEALTRGGPSGLPRPIELIAHDPIRYVGDMLAWIHQVMASEHEFLESLFDLKADGRRVGESRIFPMTDWNTGDREMARKLLDKHLEGCIRPLKIRVQQTVNSQEGSLIACQLASLLEFYQLTMAGTIGPDAKLTKTLSELTDQSYEVFYQLLRSLSSDYLKRLEPPPVDLSVPAPLREAMSNLSVIMSIYEGSTEDGASSSEHSFERVLDLVVDPMMEVIDKMARLRASEWDRSIFWLNCLEFMLATLDSSNSTSTVDKLESLRQTHLEKLIQQYTAHLTSTSGLEPVLKAIETKDQDTPLSRIEEANSKSISEALKKFDKFLMNFDTLLSSNKLLSLLNTSSSGSNNSTGGNFSKRRRKMQEEGEGERGGSQNLKEVILKRSLNDLVARYQIIYDNVLDDRNLFEFKSTILIRSLDEVKTLIGFL
The following text describes a protein:
Function:
ATPase binding tail-anchored (TA) integral membrane protein and required for the homeostasis of photosynthetic machinery.
Subcellular Localization:
Plastid, chloroplast. Plastid, chloroplast, plastoglobule.
Sequence:
MVSLVNSSLTCSSLTLNLLPILRTETPSLSRKRRAAYVAATSSRDVNDTAADSSQKLTKFVTFLGKGGSGKTTAAVFAAQHYALAGLSTCLVIHNQDPSAEFLLGSKIGTSPTLINDNLSVIRLETTKMLLEPLKQLKQADARLNMTQGVLEGVVGEELGVLPGMDSIFSMLELERLVGFFRQATRKNHKGKPFDVIIYDGISTEETLRMIGLSSKTRLYAKYLRSLAEKTDLGRLTSPSIMRFVDESMNINSNKSPFDGMTSPAMWDTLERFLETGASAWRDPERFRSFLVMDPNNPMSVKAALRYWGCTVQAGSHVSGAFAISSSHLTSQIPKADFVPLPFASASVPFTITGLDWDKILLDQANSSIRELLSETVSHGTSLTQTVMFDTAKKLVTLFMPGFEKSEIKLYQYRGGSELLIEAGDQRRVIHLPSQIQGKVGGAKFVDRSLIVTMR