lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
Sequence:
MFRASSRHTTNTNSSPEVKLSKRNSTANGVPSARYSFRLNFYERPPALDITLEEFETCAISRLRVLSHIESLSHRSLPYAQVASGIATYAKTHLPLSSNTARNVNLDDERRRDEIGHWVLRLAFCRSPDLRQRFVRSELALFKSRFETDDKNERAAFLRSLSFNYDTVGEDEKKFLKAELQQMLPKGSKEDAISETWFKVPWYTVPDLVGARRVLVKGGLAFVPQSLQLSLVLQVFADRLEKALEFTAKNLPRLDEDERLGPVIDHLASSFLSGIGASDYQPSDELGDGMTVTADTIDDVARKHFPPCMRHLYEKLKKDHHLKHWGRLQLTLFLKGLGLPLDQAILFWRRSYGTSMTDDKFNKEYRYNIRHSYGQEGRRANYPPKNCQQILTQDQPGTQDAHGCPFRHFSPENLTTFLTNTYPDHFSRTSPEMRDILDSVKASHYHVACTRVFEVTRGVKKGEGLGNGESVSHPNKWADRSRELEKEVLDGIKKKEEAMDVD
The following text describes a protein:
Function:
Involved in the regulation of root gravitropism. Functions redundantly with LAZY2 and LAZY4 in the control of root gravitropism. Functions redundantly with LAZY1, LAZY2 and LAZY4 to control plant architecture by coupling gravity sensing to the formation of auxin gradients.
Sequence:
MKIFSWVQRKLSGKKRVPTSDSSQEPSSPPLSKEVQGLPQDEETFLAIGTLGNNIFPKQEEEEEETDSSKDITPVNTDVTIGKKKSLSFLLKKMFVCTSGFKTPPPLLDLSRGDSLHNTRMEKMLRTILNKKIHPQRSNSIAKKYLESNHKIMDEARSSVDANKWVKTDSECEIF
The following text describes a protein:
Function:
Thiol-disulfide oxidoreductase probably involved in the redox regulation of a number of cytosolic enzymes. Possesses insulin disulfide bonds reducing activity.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MGGALSTVFGSGEDATAAGTESEPSRVLKFSSSARWQLHFNEIKESNKLLVVDFSASWCGPCRMIEPAIHAMADKFNDVDFVKLDVDELPDVAKEFNVTAMPTFVLVKRGKEIERIIGAKKDELEKKVSKLRA
The following text describes a protein:
Function:
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MIFPWKCQSTQRDLCNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRENYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFNCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKKSMDDPY
The following text describes a protein:
Function:
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)). Involved in glycoRNA biosynthesis by mediating formation of acp3U, which acts as an attachment site for N-glycans on tRNAs. GlycoRNAs consist of RNAs modified with secretory N-glycans that are presented on the cell surface.
Subcellular Localization:
[Isoform 1]: Cytoplasm; [Isoform 2]: Nucleus. Cytoplasm. Note=Localizes mainly in the nucleus.
Sequence:
MESQKEARTLQEPVARPSGASSSQTPNDKERREGGAVPAAAALGAEADDDSADGLWELPVEPAERRPECTRCSRPQKVCLCPFLPAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLILYPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRHPKQVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGLYPKPMPKNKRKLRKMELLMNSVKI
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MSLVWLQVGQCGNQIGQEWWQIVCNNASEADRYPYFSRDGMINAICVDSEPKVVRKLGKQVTRGNFRDSNLIVGRRGRGNNWAFGYSGVGGDTEKSLLARTMESFRHELERRDCYSGTVLLHSLCGGTGSGLGARLCEEIRDTYPAGHILSVAVAPHETGDTPLQHYNSLLCLSSLQRYSDGILLFQNDDIMHRVAALGEKKVPLVSGVETPVSLAAMNSHIASCLAGLLYPTNTLRTRSAVSVGIEPWEIIRTLCPMSTLKFLHTTQICRRGTPFWDRVTVSLTKNIPRASPDGAGLHHSTSVLAVSRASQDKSFLLSQDSVLMKLKQSYRCVPWNPFPVDCWTGSQNILDPSQQSHSLTVCANHSSAADLMRRVIHRAQAMYEAQAYLHWYQQYGCEKEDFQEAFHTLQSVAEDYSKLGEP
The following text describes a protein:
Function:
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent.
Sequence:
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP
The following text describes a protein:
Function:
Mitochondrial DNA endonuclease involved in intron homing.
Subcellular Localization:
Mitochondrion. Membrane; Multi-pass membrane protein.
Sequence:
MVRWLYSTNAKDIGTLYLIFAVFAAMIGTAFSVLIRMELAAPGVQYLNGDHQLYNVIITAHAFVMIFFMVMPAMVGGFGNYLVPVMIGAPDMAFPRLNNISFWLLPPSLILLLASAFVEQGAGTGWTVYPPLSGLQSHSGGSVDLAIFSLHLSGISSMLGAMNFITTVLNMRNPGMTLHKLPLFVWAIFVTAILLLLSLPVLAGKFVPALNLAVCWELFSSVFSKIIDVKDDQQVTYESYNFIWNLNDCAPELSISHMSSLLFFGSYLAGLIEGDGTIVVPKQERSAKGKRNYPSVQIVFQLKDFPLCQIVQKLIGHGTISKKKQAAAYILTINNIQGLIELSNLINGKIRGPKYYQFVLLVEYLNKKCPNLNLKPAGFNKTPLGFDSWLSGFIEADGSFQVRTSLSSKYPRLSLSFELVQSRITHYGFTMFTIMQEIAIFLETNVNEIRSERKNPQYRLRTSSLKTNKNIRDYLVKYPLKGTKYLDFKDWCKVLSYFEQGTHMDNTARIVEIKSQMNQRRTVYNWDHLQ
The following text describes a protein:
Function:
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
Sequence:
MRTATLYRYSVPMEAGVILRHQRLKSRDGLLVKLQQGELSGWGEIAPLPEFSQETLDQAQVAAECWLQHWVSGVESDDSVLPSVAFGLSCAQAELKQTLPLSADYRKAPLCTGDPDELFAVLQALPGEKVAKVKVGLYEAVRDGMIVNVLLEALPDLTLRLDANRSWSRAKADGFAKYVNPALRSRIAFLEEPCKTRAESREFAQDTGIAIAWDESVREADFQVEAEPGVAAIVIKPTLVGSLARCQQLVQQAHQAGLVAVISSSIESSLGLTQLARLAAWLTPVTVPGLDTLDLMQAQVVRPWPDSPLPLITTEQLGVVWHR
The following text describes a protein:
Function:
Involved in the synthesis of peptidoglycan associated with cell wall elongation, especially following spore germination. Has a partially redundant function with PBP 1 (ponA) or PBP 4 (pbpD) during spore outgrowth. Plays a redundant role with PbpH in determining the rod shape of the cell during vegetative growth and spore outgrowth.
Subcellular Localization:
Cell membrane. Forespore inner membrane; Single-pass membrane protein.
Sequence:
MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQIVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQRLKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLYQLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLDELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSYLEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIEKKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSSYAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEKSSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGYKGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIGAVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSFYDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMDKYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN
The following text describes a protein:
Function:
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane.
Sequence:
MAGEDQEKTEEPTSKKIEDARKEGNVPKSQDAAAIVTLIIGVTITLFMMSFMGERIVNLYRYYQSFIGVEFDLRIIQAIMIKSIFEVLIILAPIVLSIMIAGVLGNIMQFGFIFTTKPIMPNLGKINPLKGLKNLFSLKKIVESIKIILKVGIVFTIAFIVLLKFMQELPRVELYTMVAQLTWLRDRAIVLAAIVIVAFLIIAVLDVFLVRFQYFKGLRMSKQEIKDEYKQMEGDPQVKGRIRRLQMEAARRRMVQDVAGADVVITNPTHYAVAIRYDTGKEQAPRVVAKGVDFLALRIKQVAYENNVVVYENPPLARELYKACDVNDLIPREMFKAVAEVLGFVYNTNNKSRLAGQVKKGN
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus.
Sequence:
MAPRPSGARRSLFPEPEHVYELGVAGRKTGVTLKDSGIRDEHGMQPLEDLFSSPHKPTEDRDEDEGEDDEDGGASEDGRADSEDMDITTTSGIAPAALLNGNASRLPLPVSRTNRSPVKVVVNSPARNRLMARSSSPTRGSLGANKENYDRGSSSQPAEDINTARRRLNFEALKAGGRSLSQPTTTNGLNGLNGYHDEAEEEEQENTAVPDETDAFIEESMAMLEDNGEVEEEQPADQEEEEPEDAPEAVPVPAAKKKPGRKPKAKEPSPAPAAVKRGRKPAAPVVEEEEREEEREAEGEPEEVAPQVAGKRGRGAKGKAAAVEEPAPAAKPGRKRRTVEEPATDAEESSSSRQPKRQRTETAPAPAKGRGRPRKSLTPAPREVEEPEPEPVEGGPSRSRAAKGKGRAPTPAAEPVNEKVTKATKATKPKGGRKRQPSPAPAADADTSIAIPRGPPLPKSRGLVINRREVPGDSNAIIRTRSGRHSFKPLAYWRNEHVDYEYEEDEFVADHAPKASKGSSAGEVARKRKFVLPTIKEVVRVEEEVVDFPRSRGRGTKRGGNNAAAGGTSRRAQRDEDPSPPEPWELNPGILGGDVVTWYPQHEFHPPALDDEVEVQEKQLAISGRAIRTQKVKDAAFRYAKTVNEGFFGAGVVDLPPGAVKRPKNSRKMFMTFFVYTGRVLVTVNETVFRIGKGGMWFVPRGNYYSIENDYDQPARVFFSQGCEVQVRPSSEGDEGVSGAENSVLDTSAAASASA
The following text describes a protein:
Function:
Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDNTTNINTNERSSNTDFSSAPNIKGLNSHTQLQFDADSRVFVSDVMAKNSKQLLYAHIYNYLIKNNYWNSAAKFLSEADLPLSRINGSASGGKTSLNASLKQGLMDIASKGDIVSEDGLLPSKMLMDANDTFLLEWWEIFQSLFNGDLESGYQQDHNPLRERIIPILPANSKSNMPSHFSNLPPNVIPPTQNSFPVSEESFRPNGDGSNFNLNDPTNRNVSERFLSRTSGVYDKQNSANFAPDTAINSDIAGQQYATINLHKHFNDLQSPAQPQQSSQQQIQQPQHQPQHQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQTPYPIVNPQMVPHIPSENSHSTGLMPSVPPTNQQFNAQTQSSMFSDQQRFFQYQLHHQNQGQAPSFQQSQSGRFDDMNAMKMFFQQQALQQNSLQQNLGNQNYQSNTRNNTAEETTPTNDNNANGNSLLQEHIRARFNKMKTIPQQMKNQSTVANPVVSDITSQQQYMHMMMQRMAANQQLQNSAFPPDTNRIAPANNTMPLQPGNMGSPVIENPGMRQTNPSGQNPMINMQPLYQNVSSAMHAFAPQQQFHLPQHYKTNTSVPQNDSTSVFPLPNNNNNNNNNNNNNNNNNSNNSNNNNNNNNNNNNSNNTPTVSQPSSKCTSSSSTTPNITTTIQPKRKQRVGKTKTKESRKVAAAQKVMKSKKLEQNGDSAATNFINVTPKDSGGKGTVKVQNSNSQQQLNGSFSMDTETFDIFNIGDFSPDLMDS
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC35.
Sequence:
MNEVSIRTLNQETSKVLARVKRGEEINLTERGKVIARIIPASAGPLDSLISTGSVQPARVHGPAPRPTIPMRGGLDSGTLLERMRAEERY
The following text describes a protein:
Function:
Transcription factor that positively controls filamentous growth, virulence, and invasiveness. Binds directly to the two SRE-1-like elements upstream of TEC1 and thus positively regulates expression of this important hyphal growth regulator. Functions independently of known signaling cascades involving EFG1. Also regulates gene expression during intestinal colonization but is not involved in host cell adhesion.
Subcellular Localization:
Nucleus.
Sequence:
MLSQYDEQLAAGDNNGFNKQGNATLYSFDFVDADDFLDSISGALPNNGHNNVNPNTNDISFEDMNIMNPNIYSPVSAASGDDFTQSSGQPMISEGSNYTGQNFTDYLSDNSLEGYDKNTSRPLHEVDIGFSNKRSNSTSTGSLSHNEEITPISHYSVDSIVTSPEPPINKQGDFPPIKRTTTVSSTNSITNTTKKPAKVTKPKSKDKNSHNMIEKKYRTNINTKILALRDAVPALRIAAGCDDVSIADLEGLTPASKLNKASVLTKATEYIKHLESKNFILKQQNIELHRLIQHANMNPKSLPPPPQQMQAPPQPGFGFYPPQNQSFNVTPASQYPSPQQQVSPTQQQTVHHPPQPNRYLLGGMAAVMGTSLFGGSGENDFRSLSALPFSYLFPNAILNPSPLTIQLWTLTKVLLVVGSLASIFIPMYKQAQLKKEDKPNTIPETSLLDWILISIGFKTPAKLSVSKRDAIISNLQGGNDWSQLVSDYFYLAGCEINFENCFLSLVLGTIIRHRFPVVATILNHYLSMKEALLLNLDYKGFSKSLIRLNQLISKVDGVSIFESTNLTTRLTNVFTNNRINANIVDGQNHVKYIEFYQRNINDYYAIVFNWRLLEFIHELNVTYLEQLNDDQSQVLTDLKIIEAFFGEQDNKLFGYYQLFTSILNANYAPYLFESLKDKVESSLEKFRIAYEGIDLTDHEIHNTSSEDEYEQESPVVYKYEPTLKSQKSLISSLNLVNEEEFIILTCSLTIYYYKNKEYDRALKLLNYLRLDNDSKTLSLLTFTSLITLINELIPGKIEDNVNLDSAIRICRDWLENPDLTQYMDEDIKLELKKIVVTKGMIVNGIDVNESDEE
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPGVASFSGRGGHGPMDFDAVVLAGGLSKQLYPLVSKELPKALLPVGNKPVLSYTLEMLEANNLTHPHVVVAGEEAASRVRAWISDAFQDRLTARVTAVPEDSGTAEALRAVAHQIRAKDFIVLSGDLVCDVALGAVAAAHCRSTAAATALLCSQPNSSFAAESKDKGKATTAPPVDYIGLTTDGSSLLFCASAADVEHELRIRRSILRAAGQMVLRTDLMDTHLYVFNRVVLDVLEAQPGIASVKRDLLPYLVRTQLSPLPSSVTGPSSGPDDAVSREDSSGSAAGPVASPSLVEALSHPARRGLAGAVRRCGVYLAGPDKFCNRLNSLQQYIEVNREVAGDAVHLTGFPVSSFNNVVHPSVEIGSKTTVGAQCVLGEGVRLGDKCSVKRSVLGKNCRIGANVKIINSVLMAGCVVEDGCHVQNSVVSAGGHLQERASLKDCYVGAAYTVGTGEEHRGESLAKKQ
The following text describes a protein:
Function:
Secreted effector that interacts with and inhibits host apoplastic pathogenesis-related papain-like cysteine proteases (Probable). Inhibition of host proteases by a pathogen extracellular protease inhibitor forms a specific type of defense-counterdefense mechanism between plants and microbial pathogens (Probable).
Subcellular Localization:
Secreted. Note=Localizes to host apoplast where it targets defense proteases for inhibition.
Sequence:
MAFTRSIALFAGLALAASSAQGATILGGYTQKNATSDDIELLTQATSSANMYNKNVDTRICLIAIENLETQTVAGTNYKFQVAGCPVETDDELGACDDRNCDYSSYNIVIFSQPWSDTIEVTSITPAEYQG
The following text describes a protein:
Function:
Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTKLKGLKELGNTSDPLRTVSYQVRTKMSDYEDDNTDVQSLTVEEEYELWNSNVPVMYEFVSETKLTWPSLTIQWLPSDGQSPEQSLIFGTHTAGEEVNYLKVATINLPAGIAGLDQGDEEDEANDHSSFAIANKFPHIEEVIRARYMPANSNIIATINGKGTISIFDRTLEESKAQVSTLAFHKENGYGLAFNPHISGELLSGSDDTTVALWDIEAAKKPKSILTSHDDIVNDVKWHEFESNVFGTVSEDKTLQVHDKRVRLEPVKKLPTASPFNTLSFSKHSRNLLAAAGVDSQIYLYDMRDMSSPLHVMSGHQDSVTTVEFSPHTDGIICSSGSDRRAIIWDLTQIGAEQSQDDADDGAPELMMMHAGHRSPVNEFSFNPQIPWLLASTEEDNVIQAWKVSMKLVNASPPAISDPSLLV
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Zona pellucida.
Sequence:
MACRHRGDSGRPLSWLSASWRSLLLFFPLVTSVNSIGVNQLVNTAFPGIVTCHENRMVVEFPRILGTKIQYTSVVDPLGLEMMNCTYVLDPENLTLKAPYEACTKRVRGHHQMTIRLIDDNAALRQEALMYHISCPVMGAEGPDQHSGSTICMKDFMSFTFNFFPGMADENVKREDSKQRMGWSLVVGDGEKARTLTFQEAMTQGYNFLIENQKMNIQVSFHATGVTRYSQGNSHLYMVPLKLKHVSHGQSLILASQLICVADPVTCNATHVTLAIPEFPGKLKSVNLGSGNIAVSQLHKHGIEMETTNGLRLHFNQTLLKTNVSEKCLPHQLYLSSLKLTFHSQLEAVSMVIYPECLCESTVSLVSEELCTQDGFMDVKVHSHQTKPALNLDTLRVGDSSCQPTFKAPAQGLVQFRIPLNGCGTRHKFKNDKVIYENEIHALWADPPSAVSRDSEFRMTVRCSYSSSNMLINTNVESLPSPEASVKPGPLTLTLQTYPDNAYLQPYGDKEYPVVKYLRQPIYLEVRILNRTDPNIKLVLDDCWATSTEDPASLPQWNVVMDGCEYNLDNHRTTFHPVGSSVTYPNHHQRFDVKTFAFVSGAQGVSQLVYFHCSVFICNQLSPTFSLCSVTCHGPSRSRRATGTTEEEKMIVSLPGPILLLSDGSSLRDAVNSKGSRTNGYVAFKTMVAMVASAGIVATLGLISYLHKKRIMMLNH
The following text describes a protein:
Function:
Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP-octanoate (82%), pNP-decanoate (90%), and pNP-laurate (74%). Is probably involved in lipid catabolism. Is active at low pH, and might play some important role in mycobacterial biology in macrophages where the bacteria encounters acidic stress.
Sequence:
MIIDLHVQRYGPSGPARVLTIHGVTEHGRIWHRLAHHLPEIPIAAPDLLGHGRSPWAAPWTIDANVSALAALLDNQGDGPVVVVGHSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDAMLASPDYLDPAEARAEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRISLPAMVCYWSELARDIVLPPVGTATTLVRAVRASPAYVSDQLLAALDKRLGADFELLDFDCGHMVPQAKPTEVAAVIRSRLGPR
The following text describes a protein:
Function:
May be an activator protein for the gylABX operon.
Sequence:
MPDPRGGAQGGGVSGQEGPTLISSVQRAFRLMEAVGAHESGVPAKQLARETGLALGTTYHLLRTMVHDGYVRKLEDGTFVLGERLGALHAGSRDQTALSRVRPTLTELRDDLSAAAYLTLYEEGEIRVAEIVDGPKAPRVDLWVGFEDAGHATALGKSVLRELDAEARADYLSRHALNDLTPRTITYRAQLLRSLDAAPRGPAVTDLEEYRLGTACVAVPVRRGDTIGSLGISVDINRTACLDDAVTTLLATAERVSRGLSLTI
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MPQSDLFGLEMLWKLESANLADKADAMMLFVHWFLVRNGFRNVGVGDDKTLNNAVDQSELLPEGWNGNNKSYALRYIMNNELYILHGTLSNDTMIVNLLQAQSLQVSNAAFNLDKTITSFNDSNLTNVVVSIDDQITRLQTELIKPLCDGGSKSSSTQTLISSSPSPAQVNVVPAGGPRRIQVLRPSGLLLPFGGGGVGRGDLNPLGGVVGGGGGGGMLMDPMNMGPGRVDPFLPGARIDPMGPFPPRVQRPNPNPDHLPPPGYDDMFM
The following text describes a protein:
Function:
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MYRFGPTHNRKRNNNSRFCVTFVTIMALRFVALLLMATLQGGHCDNCSYNSLVKNALNLSESNEMYMKVRPVNNWRNCSVVYVDMTLYTIVYLDMYKQSMISYLWVKMDWINELISWNSTDYCNINKVLVPSDNFWLPDLYIYELTEQNSPSRVNYVEVQNDGKCSLSVPLRSVSSCDLKLYKFPFDDQSCNLSFGPYLYPVTEVTMLPFSDSKTVTEKSNNRYSGKGDWDFISVKVTNTSYDWNGAYYSRIYYEISIKRSPIAYVMNLILPAGLLLVLDLCSMCMKASFDERLGFKITIISGFVVLLLILNDILPDSDAMPALGYFFCASLSIMVVSSVGSIMILHVLSQCSSHSDVPPWIKTWILKYLAYILCFKKKFHTEDIASFVPADNEYKTEKISDECPIRSEKTQTTAKHALEVKMLKKFLIEILKIRKELLISKKANENKSDWSSVVQVLDRLLLILYITAMSVTFIGTAITWAT
The following text describes a protein:
Function:
Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition. May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1.
Subcellular Localization:
Nucleus.
Sequence:
MLPCFQLLRIGGGRGGDLYTFHPPSKSGCTYRLGCRADLCDVALRPQQEPGLISGVHAELHAELQGDDWRVSLEDHSSQGTLVNNVRLPRGHRLELSDGDLLTFGPEGQAGTSSSEFYFMFQQVRVKPQDFAAITVPRSKGKTGAGFQPMLPPQGAPQRPLSTLSSAPKATLILNSIGSLSKLQPQPLTFSRGGGRQQSLAVPTQPGEVGASPAPPTRNRRKSAHKVLAELDDESEASPGHLSVLMEPRKKLRLEKTALISSGE
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MLCSLFLCCEIHFSYFISLSLSLSLSLFEGAKRTAQSEGSLVEGTKTWAQLTPAEKVVEGGKDSGSALVIGAGLTLCGYLLYSVVSELVFRDGPEQFFERSLKRITNDEEVRLALGDAVTFVGSMKGPNKPWRMQEYVVDGTTYTRMRYEIKGDRARGVVHLEMKKPASGKPTMRYLFADLQGPLGNTNRVVLEDNRIEDKQAASVQE
The following text describes a protein:
Function:
Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MAEAATEIPPTASNVTVFTFEEQATSSLALYGMSILCIIIGSIRSAQYIRTNIDKKRLIEGSITMREARKFPISASLVLFGLYLFFKPAAERFLWVARVFQILRVPEEYVQKINSTIISYTANTTTTGPSEPFLLRLASRIPQERVPEAIQNAATYAYTNLPTIQKAECMQLLTFLICFEGVNAFASLLKPFVTAFLKKMPLVPSFLRFNAPYLFSLKKGNKEMEEGDIEDAKKKETEYLFKIDFDRYDIIALLMCSPILISHLLKRHWITNNIIGVSFSILGIERLHLASFKAGSLLLVGLFFYDIFWVFGTDVMTSVAKGIDAPILLQFPQDIYRNGIMEASKHSMLGLGDIVIPGIFIALLRRFDYRVVQTTAESKAPQGSLKGRYYFVVTVVAYMAGLFITMAVMHHFKAAQPALLYLVPCCLFVPLLLAVIRGELSALWNYDESRHVDNEENRKKVDSGKKNN
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVLIAIMPITFNLQLNPELFLVMFIAPLLFNDGRQTDKAALWGMRMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAAALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLVAFQFAIAAMVTGVFSLMDASISFFVIAIGGILVGLILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLAAEEIHVSGILAVVAAGIMHSMEQKKMDPQLVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPAITEVVWNDSGSSNLQVMAYILSITAALILLRFIWVYISWSIGAKQRQKQNKKTQLPKFRPVVLTSLSGVRGAVTLASALAIPFFLDDGSLFPQRSLIIFIASGVILCTLVIATFILPLLAKSEEVTTEDERAEIATRIRILRNVIRELKEQTLPETKAATDEVIEDYRKRIYDLQQNNSSNRGMDERERAKRLEIIQWERENTQKMTDEGRIVATDSYRYQHYLNMMEQAIKQRFRTKVKTAWMFLYRLIMLVIHPKKWGRITHKVKKGISKDSERFQAIRQLREDNEILIISKLKEQLTKENVDIIGPLITEHTIFLERVRKEHSPRGKRAKFEQKKREVQVVAFQLERDIIQNMFEKGGISRELARDLRQNLNMIETYLYDDFLE
The following text describes a protein:
Function:
Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTDSVHHAFRGLNLGDAQQDPRKQLHHQQQQQLHQPYSSPTRHTESTSLRSPTILTTDLHGQHGYHTASIGASHPVTAPSDGSIGQSAAARFERFFPSSPNTSTSNPSSAGQTFTSSIGSAAGLAANGAFGSFGQSLAPGSMASSSISSAHFGSSSNAPRKAPSRAAIPAQWSSQDPSSLVPPAGTSPPNNMGSLPSYHDPIAQTAAAAAANNNNNNNGDDDVIPTAIVVKNIPFSVKKEQLLQIIEDLGIPMPYAFNYHMDQGVFRGLAFANFRSAEEADAVVAALNGFDVSGRKLRVEYKKVLQAGEKERIEKEKAIKRMQSMQLEKERRRQNDEYTAHAYLMPGYNASNGHLAANDAYSADPAISGLQHAVYDGSVIAPLTADSLRKVPSSQRLAAAVERPSGPSSSTSNPGVGASNQFGAAAGAAAAKKEELDLNDAATLEIYSRVLLFKDDRMRDELAFSRSLTPLERRTVHLVAQRLGLFHYSMGDGDERYAIVTKNDVHAQARPLRSQASTIGRAQRSTGIDAAATGGFLGPGSAATTGRAGLRLKKSAPDMKRDRDGSTGYSAANGYLHSSNGSSSLAARKSNSNLRDGYSSTMGRRTQNGSNNSNSNSNSNSTATGGAAGLQNLFASPFDAPPVPSLTNVNAPEGSSHTSSPTHSTLLRQPRGPPTPGSSDSRNFAVRSRVPTAGTSSTGSTTSPPPPAHAGFQLHINGSPTKYHSSEQATTQEPLEF
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MADVDREGSTLRARKSTNEKHAVASTRSTHSKLNVSRSAVFNLVFFSILVFAVPLVVFFYGMNHWFQDNPTLAGIAAALSANAVVILFVVVAFSESDESDKNDSINNKSDKSK
The following text describes a protein:
Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MPKSKRNKQVTLSKTTKKGRGHKELIINGIRDAAEKYSSIYVFNFQNMRNSKLKEFREQLQSSSKFFLGSNKVMQVAIGRSSSDEIKPNLHKVSKLLRGDAGMIFTNLSKEEVERLFNEFEGYDFARTGSIATEKVELKEGPLEQFTHDMEPFLRKQGMPVRLNKGVVELVSDFVVCEEGKPLSPEASRILRLMGNMMATFRLNLVCRWGSEDDFELYIDGPGDSDVE