lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Subcellular Localization:
Basolateral cell membrane. Cell projection, cilium. Cytoplasm. Nucleus. Secreted, extracellular space, extracellular matrix, basement membrane.
Domain:
The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
Sequence:
MSFMQEFLAQASFLEGGGHPPCTAEESGPSLKANPGFNAAADAANLDKAIKAKGVDEGTIIDILTKRTNSERQQIRAAYQQLTGKSLDDALKKCLKSHLEEVVLGLLKTPAQFDAQELRGAIKGLGTDEDSLIEILVSRTNSEMREINKVYKEEYKRELAKDIAGDTSGDFQKTLLALAKGERNEDTRVNEDQADNDARALYEAGEKRKGTDVPTFINILTTRSFPHIQKVLQRYARYSKNDLNKAIDLEMKGDLEKCLMSLVKCASSKPAFFAERFYLAMKGSGTRHNALIRVLVSRSEIDLKEIKTCYKRLYGKSLRQAVMEEKLKGDYETIMLALCGSDN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow.
Subcellular Localization:
Membrane, caveola. Membrane; Multi-pass membrane protein.
Sequence:
MEVKVKNPWHRPVVIFLMAVVAVGIVIMVSISVVQHKPLPQKYKYGIVLDAGSSHTSVFIYKWPAEKENNTGMVQQHHTCNVKGKGISSYFDKPHGAGASLEECMKEAKEKIPAHRHSETPVYLGATAGMRLLKMEDEMASEKVLTSVAHSLKTYPFSYQGARILSGQEEGAFGWITVNYLSENLRKPAGTLGALDLGGASTQITFVPQQIIESSDNSIDFRLYGNDYHLYTHSFLCYGKDQALKLAMAEKLRSTPDKTDAILLRDPCFHPGYNTTKTLESVNTPCMKPLKMPKEQFSHVGLGNWSQCQESIRKVFNTSHCPYSGCSFNGVFQPTVEGKFGAFSAFFFVMDFLNLKNDSLDKTKQRLAMYCSTPWQKIVQDHPKVKEKYLSEYCFSATYILTLLEHGYNFTSDNWNDIKFIKKIGDSDAGWTLGYMLNLTNMIPAEDPDKPLMPHGGYVTFMILFSLLILVLIIMAYIYFRRFTKTAQKDII
The following text describes a protein:
Function:
Involved in oxygen transport from gills to the various peripheral tissues.
Sequence:
MKPQKTTVGFFKWSLVEELTHIHKRHRPHNYDSKADEIGAVAMGRLAILIFPFTKTYFSHWSDLSPDSAQVKNHGATIMAAVADAVAGIDDLTGSLAKLSVLHASKLGVDPANFKILAHNIILVLVHVSVDKFLNNLAWLWLRDC
The following text describes a protein:
Function:
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Subcellular Localization:
Cytoplasm.
Sequence:
MKSKASAPGKVILFGEHFVVYGVKAILCAINKRIAVTAEKIDERKISIKSNIGHLELEPNKPISEINSPLKPFYYLANKIIQDKNFGIKIDVESEIPLGVGLGSSSACCVAGAAAISNLFENNSKEEILKLAIEAEKTIFQNTSGADCTVCTFGGLMEYDKENGFSKIESEPNFHLVIANSNVEHSTESVVAGVRKFKKNNEAEFSKLCKDESHLIENVLELLKENNIRELGERVIKNQEYLERIGISNAKLREMIQTGQNSSFGAKITGAGGGGCIFALTDESNLENTIKEFKEKNHECFSVKIDFKGLDTF
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MADPRVRQIKIKTGVVKSLTASICKRQDLNAGLTHAKKMLFSSLCFPSIRLVKEKLMYEKEAKQQEEKVEKMKAEDGENYAIKKQTEILQESRMMIPDCQRRLEAARSDLLQLLVCKTGHILSYVLGLFQPNILKNQISIFVTKD
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGGIKKFKKGEKGENLKFITRNEAVKKLQISLKIFRKLCILKGIHPRDPKKKFKGKHKTYYYSKDIKYLQNEKVLEIIRARKVFKDREKKLINKKQFGALKNLKENRPMITLDHIIKERYPTFQDALKDLDDCLSLIHLFANMDASAKVRENQILACERLAREFQYYIIQSKSLRKVFVSVKGVYYQADVMGETITWITPLNYLSKKEKEVDYGVMISFLEFYQALMKFVNYRLFTSIGLTYPPTIDDAKLRKCDSLINIFESKPQQQTKTNNTTKKSKSTTAAAAATTPVDPKLKKLEEKISKINSKEEKEIKEQIVEEDTNMLQVNSSGISKDFEDLVGNESDNIPKIMDVTTLFKGFHFYISREVPRHMLEFVILSFGGRVSFPGSGDKVKEVNQSITHQIVDRSNSVKVHNTREYIQPQWVFDSVNSKLLLPYSEYTIGVIPPAHLSPFVEYEEDSYIPARKQALDALINSKEFADAKINTNAEQDDDNDNDNDNRKQVDSDGESDDEDDEDLEHLETRYTEELRKEQSKKRKSSEVDDDDEEEEDGEEDGEEEEEEEDGEEESESESESEQVAKPVLTKKQRDELNKQKQAEEDTKLAELMIRKKDKWIYNKVKETNQQRATANQTLLEKRNKVESGKDVNGNVKVAPQPKKPAPLVKKSQQKQQQASKKQKK
The following text describes a protein:
Function:
Stimulates the interaction of procapsid with the terminase-DNA complex, thereby increasing the overall rate of DNA packaging. Before packaging, it likely coats the surface of the procapsid through binding mediated by C-terminal domain. FI presumably dissociates from the capsid once it inflates upon DNA packaging, and is not present in the mature virion.
Subcellular Localization:
Host cytoplasm.
Sequence:
MTKDELIARLRSLGEQLNRDVSLTGTKEELALRVAELKEELDDTDETAGQDTPLSRENVLTGHENEVGSAQPDTVILDTSELVTVVALVKLHTDALHATRDEPVAFVLPGTAFRVSAGVAAEMTERGLARMQ
The following text describes a protein:
Function:
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MESLRKSLQAVAVLGAGAGLGVFLFVLVTPGEQRTRDLLKEKNPQHLDEATKSKILWMDTLREAAETQENVAWRKDWNRQAGGRAA
The following text describes a protein:
Function:
Involved in microtubules reorganization during spindle and phragmoplast development. Required for gamma-tubulin localization during mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Preferentially localizes to microtubules minus ends.
Sequence:
MSSARLCSLVAELGYEGAGKLDPDSFEWPFQYDDARPILDWICSSLRPSNVLSLAELSLYEQFQRDGKLLEGDDLDQAYDSISAFSSRRNNQEAVFGAEESIKEVRDATLAHKAEALELQRQLRRLQTQYDLLTGQSSALIQGRRARVAATSAVSGQITAIEDSLSARNLQMNGVLGRLASTSQELAHYHSGEEDGIYLAYSDFHAYLAGDSACTKELNQWFAKQLDTGPYRLVAEEGKSKCSWVSLDDTSNMLRDLEKSQHQRVAELQRLRSIFGTSERQWIEAQVENAKQQAILLTLKSQVTSVEAHIHFDLHSLRRKHADLVEEISTLYQKEEKLLSETIPELCWELAQLQDTYILQGDYDLKVMRQELYISKQKVFINHLVNQLARHQFLKLACQLEKKNMLGAFSLLKVIESELQGYLSATRSRVGRCSALIQAASDVQEQGAVDDRDSFLHGVRDLLSIHSNTQAGLSTYVSAPAIIQQIVALQSDLSSLQSDLENSLPDDRNRCINELCTHIQNLQQLLFASSTTAQPILTPWPLMKELDEMGKINSKLSTAVEEVTLEHRNKREIVKHHAKDVELQRRVFVDFFCNPERLRNQVRELNALVRARQASSS
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MSESSVKQNDSIEDEQYRRLRQEYRSMIEHVEQNMEQYAQPGSSGIKETLEKAANLIRGVNRTREAVLDSQLLVAASKIARKQAQNVSNEGNVFDTDAFINTLKTYLSPHNFNHSVSDSQEMPLDWAKLGRRCLRCFRSVPAVNTMYGPAKIQPRVKKQSNRSSRKEAVIPNAVVRPKEDGKVKITVENNIPKIVPLQTVDRSESENCNKKQTVISLDHNTWQELISSFKIDRCLITPRE
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MTNLKAQKRLAASIAGVGINRIKVVEDYIEDVQSSLTRDEIRNLIKDGKIIVLKKVGISGGRLKERRKKRSLKSEGKKSGSRKGKKGARANSKQMWVKRVRKIRAYLKWLRDHKVIDRHTYRELYLKTKGGNYKGVSDVRNVLIQMGKIKG
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Sequence:
MIGALARKFFGSANDRRVKGYQSRVNAINALEPELIKLSDEELKARTADFKKQLAEGKTLDDLLVPAFATVREAAKRTLGQRHFDVQLIGGMVLHEGDIAEMKTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLARRDSGWMGQIYGFLGMTTGVIVHGLDDAERKTAYACDITYGTNNEYGFDYLRDNMKYRLEDMVQRPHFFAIVDEVDSILIDEARTPLIISGPLDDRSDFYNTIDGFLPKLDKTDYDVDEKQRTVTLTEAGMEKIETLLRDAGQLKGESLYDVENVSVVHHINQALRAHTLFTRDKDYIVRDDEVVIIDEFTGRMMPGRRYSEGLHQALEAKEHVQVQPENQTLASITFQNYFRMYEKLAGMTGTAATEADELFDIYKLEVVEIPTNLSVARLDEDDEVYRTQKEKYAAILAEIERANARLQPVLVGTASIEKSEVLAEFLKSNGYKQIDFGKENALDKLYAAARAGKPSKLFAVLNARFHEQEAYIVAEAGVPGAITIATNMAGRGTDIKLGGSLEMRVPKETAGIEDEAEKARKIEQIKADVERFREIVLKAEEIVEIEPAKGSKPAKTVTKPGGLYIIGSERHESRRIDNQLRGRSGRQGDPGRSKFFLSLEDDLMRIFGSDRLDSMLQRLGLQEGEAIIHPWINKALEKAQQKVEARNFDIRKNLLKFDNVQNDQRKVIFDQRVDLMKDDSVAETVTDMRHAFIDDLVAKHVPEHAYAEQWDVAGLKEELKRVLDLDLPVDDWAKEEGIADEELLNRIENRADEHMAAKVAQWGPDVMRYVEKTILLQTLDHLWREHLIMLDHLRQVIGLRGYGQRDPLQEYKTEAFNLFQEMSAHLREAVTAQLMRVEIVPPEQEAPVLPPMEAHKFDPNTGEDEMALASVTLGAPASDAAQRDPKNPASWGKIGRNEDCPCGSGKKYKHCHGRYA
The following text describes a protein:
Function:
Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host (By similarity). Cleaves adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP) and inorganic phosphate in calcium-dependent manner. Triggers proliferation of host peripheral blood mononuclear cells (PBMCs) and IFN-gamma/IFNG production.
Subcellular Localization:
Secreted.
Sequence:
MFLKFCIVAFAICLSINLSEGAPRSGTIYNFAIIADLDKKSISPKNDNNYKSIVKVGELIEVGDKYSVKMKKEDHEIFTKYAYKGRGAELSEFLIYKWKLYTFDDKSGIVFRLKTNADLIPWVTLANGNGDQTDGFKAEWATTKGDKMYVGSTGISFTDKTGKLNSNSLWIKEIDQDGKVQSLDWKEQYDKIKSAMKIPNGFIWHEAVNWSKLKNQWVFLPRKCSERPFDTKTEETIGCNKIIIASENFEIIKSIQIKGKSINRAAGFSSFKFLPDSDDQILLALKTIEKDDKTATYITVIDITGRVLMPEMQINSDKYEGIVLLKSTEGFLKRSQ
The following text describes a protein:
Function:
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDAQNRNRAHSSRSSSSFFSDADRHAHLLMGHAPGTIIPNRIFVGGVDYKVTENHLHHIFSHYGTVTEVKIVTNRSGMSKGYGFVTFEAPEDVVNILSKANRICYRDKKFSISQAVQKSQAPGPGSIVHKPFIHHDPTCDTVYLTTPAGFPYTFHNGVAYFNCPAMNQAARQWSPPQSFPQHLQWNAVQVQAPSTAVLYSQQAEFLYQQADGASFLPYLPVMEDAAAQMLEPTVSAVYQGSSALVLQHDPVKSRMLPPPQGHRRREGSPAHCRRCASQIHGPTPPQVFQQQLQTEPSKDRFPDGQTSPQVFQQRLQTKPSKVSFPDGQTSPQVFQQRLQTEPSKDRFPDGQTSPQVFQQQLCLLHLILTVDSPELPACISMKDPVCCRGALGWFLVLIDQSGPQV
The following text describes a protein:
Function:
Protein kinase involved in regulation of actin cytoskeleton organization and endocytosis. Phosphorylates the endocytic protein SLA1. The CDC28-CLN3 complex phosphorylation of SLA1 enhances its further phosphorylation by PRK1, weakening SLA1 association with PAN1, an activator of the actin-nucleating ARP2/3 complex. Plays a role in cell wall regulation and required for oxidative stress survival.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Note=Localized to sites of endocytosis.
Sequence:
MPQPPPNAYKAGTRLTVGSHKVSIIKYISEGGFAHVYTCTIDPPFQGSTVACLKRVVVPSKWQLSLLRQEVDAMRRLRGNKHIVSYIDSHASRLGDSNTSGTNHSQQQQYEVFLLMEYCENNGLIDFMNTRLVNKLTEKEIIDIMYQVTIGVAMCHHLRPPLIHRDIKIENVLIDGKGVFKLCDFGSSVNYLPPPRNPQELQLMKDDLMQHTTPQYRAPEMIDLSKGFPIDDKSDIWALGIFLYKLCYYTTPFERPNQSSLQELEHTILNCSETLRFSDQPGSIFSPRLKNAIKVCLRADPRRRPNAVQLLGEIAAMKGEKTIPNVVPYSVIEQQRTKQASALEEDTKKGQASFVETKKITSKPKTDPFANIDKSKFLNKSGYKLSSVTAESRTVPARPLSAFFDDGNTPRIYSQGNRSTPSVQDYVKEELAKGESYEFNEPDGTLEFLKSREEEKLNQRNDTGGSFKAAFKNGLRKISTGGNISANNTGSSVKSNRRASLKRIITGGSNHNRKHSEENTKNVEDSNPVSSAPKKLSIQHRMQQLLNQNDHQRVQKSAQGYGKYTDIKASEDIDEINKPTLSKHSQKKLSPPAVPVNLSSQRNKSQQSSSTTKKYPIKDSKPLSKVRNNPPKDSVKTKPPPPKPKKPVYLKSPTKLEIADQRRLSDASEISMPDLDDLEKQFSKRFPSYV
The following text describes a protein:
Function:
Probable component of a branched-chain amino-acid transport system.
Sequence:
MIKVKNLNAGYGKLQILFDVNAKIEKGKITTVVGPNGSGKSTFLKTLFGLTKIYSGEIIFKDKDIAKVPPHQKARMKIAYLPQTNNVFANLTVEENLKIAGYVLDKDKVKERIEIALSVFPELKDILKRKAGTLSGGQRQFLAMGMALVRDAEVLMLDEPTAQLSPKLAEVIFEKIIEMRDNFGLTILLVEQNAKRALEISDNGYMFVSGRVAFEGTAEELLNHEKFKEYSLGITAV
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion.
Sequence:
MLLTRTASRLQCLPRPAVTPNKALSSSTRALATVTDKKYIAVLGGGISGLTSAYRLAQHLPKDRYNIVLLEHQNRLGGWIRSERIVLPTADGAAQNVTALIEQGPRSIRPAGYSGLMMLELVRSLGLLERMLKVPKTAPSAQNRYLYYPDRLAKLPSSIPSLLSALFKLPFLRAIIPGVLREPRVPSRFLRPRSESKSEKQRLQQREWIQDESVDSFVSRRFGNGLAENLVSAVIHGIYAGDTRKLSIRAVLPFLWEAERVHGSVLRSMLSTKRNKRHRALPEPEAAVKAAKDLRLENIEKELGKDVVESFKSISVYSFQEGVQEIVQALESRLAEYDNVQIKKGDAVQSIHRNEAGKTTLHTESGETMVVDRIISSIPSTRLAQILPSDAELPHLSHNPSANVGVVNLVISPSAVASSSKPLVPVEGFGYLIPRTSPGNQDGILGVVFDSDAIPEQDSVCAASRPVKLTVMMGGSHWADLETLPSEADMRARAINAVSQHLGIDRSLLEDASKVSVRATMQKDCIPWYLVGHPVRMSQLHKALEKDELLGSKLTLVGASYTGVSLNDCVAYATEAVEQIVDAELHGGERIVTGLASFAIPPVPPSQKATSITAQARKGDTRPSVNPQGLMGPITGTPNQFAVAGSIHTRAFSTTRQKSNSSSSSSSSSRSTPVSSADKKTKSLNEILLDSIRASGPMPVSTYMRTCLLDPMQGYYSSANSPSTSREVLGSRGDFITSPEISQVFGELVAIFYLARWQSVGAPSATRIVELGPGKGTLLADMLRTFATFKPFMATLKRIHLVETSEGLMELQLNAIKEALGVVGKRVVSAEEDAGADGVVVEWFPGIDMVPVIPEELTILTAHEFFDALPTHIFEKGVDGKFREVLVGIKPTSSITVLKPGQDLQKQAQNEELGFVLSPTPTPWAQMLVQNNPRFQHLEPGQRVEVSPEAWAVARRVGEIVAGRSASAPSSPKQEAPRSAPEGSAEAKAEAALEAERLQAERRLETQRLSHATEGGIGLIIDYGDDKAYGSSLRAFKNHALVRVFDSPGTVDLTVNVDFLHLKSAIHTTDARYLGPIDQADFLVGMGLQMRTEALVKGRDAHDENRIKDAANRLIDESGMGIQYKALAITARRCAENNAPDQHRDKVADPDIYPFEFQH
The following text describes a protein:
Function:
Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Cell projection, axon. Note=Detected at the nodes of Ranvier. Detected at immature heminodes; [Gliomedin shedded ectodomain]: Secreted. Secreted, extracellular space, extracellular matrix. Note=Proteolytic processing gives rise to a soluble extracellular domain that is secreted. The gliomedin shedded ectodomain localizes to the nodes of Ranvier.
Domain:
The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding.
Sequence:
MTRAAERGQGATGWGLRGALMAVALLSVLNAVGTVFVLYQWRELSAALRALEAQHGQEQREDSALRAFLAELSRAPARVPEPPQDPMSAARNKRSHGGEPASHIRAESQDMMMMMTYSMVPIRVMIDLCNSTQGICLTGPPGPPGPPGAGGLPGHNGSDGQPGLQGPKGEKGAVGKRGKMGLPGATGNPGEKGEKGDAGELGLPGNEGPPGQKGDKGDKGDVSNDVLLTGAKGDQGPPGPPGPPGPPGPPGSRRAKGPRQPNSFTNQCPGETCVIPNDDTLVGRADEKVNERHSPQTEPMITSIGNPAQVLKVKETFGTWLRESANRSDDRIWVTEHFSGIMVKEFEDLPALLNSSFTLLHLPHYFHGCGHAVYNNSLYYHKGGSNTIVRFEFGKETPQTLKLEDALYFDRKYLFANSKTYFNIAVDEKGLWIIYASSVDGSSILVAQLDERTFSVLRHINTTYPKSKAGNAFIAQGILYVTDTKDTRVTFAFDLLRGKQINANFGLRMSQSVLAMLSYNMRDQHLYSWEDGHLMLYPVHFSSTAPSQR
The following text describes a protein:
Function:
Probable pentose-5-phosphate 3-epimerase.
Sequence:
MILHPSLASANPLHYGRELTALDNLDFGSLHLDIEDSSFINNITFGMKTVQAVARQTPHPLSFHFMLARPQRWFNALAEIRPAWIFVHAETLDYPSETLTEIRHTGARAGLVFNPATPIDAWRYLASELDGVMVMTSEPDGQGQRFIPSMCEKIQKVRTAFPQTECWADGGITLAAAQQLAAAGAQHMVIGRALFSSSDYRATLAQFATL
The following text describes a protein:
Function:
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasmic vesicle.
Sequence:
MTLSLNNLQNVIYNPIIPYVGTISEQLEPGTLIVLRGHVPSDSDRFQVDLQCGNSVKPRADVAFHFNPRFKRANCIVCNTLKNEKWGWEEIVYDMPFKKEKSFEIVIMVLKDKFQVAVNGKHTLLYSHRISPEKINTLGIYGKVIIHSLGFSFSSDLKSTQASTPELTEISQENVQKFDVSQFPSNRGDISKIVPRTVYTNSKGSTANHTGTKILPTNCLSKTLPFVARLNSPMGPGRTIVIKGEVNTNAKGFNVDLLSGKSKDIALHLNPRLNVKAFVRNSFLQESWGEEERNITCFPFSPGMYFEMIIYCDVREFKVAINGVHSLEYKHRFRELSNIDTLEIDGDIHLLEVRNW
The following text describes a protein:
Function:
Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Preautophagosomal structure.
Sequence:
MPQYFAIIGKKDNPVYEIEFTNAENPQGFPQDLKELNPFILHASLDIVEDLQWQINPTSQLNGNGGNGSNGGGGFLRSRAVNNTDNCYLGKVDHFYGLAITAYISYSGMKFVMIHGNSANSSVVIDDNNMRSFYQEVHELYVKTLMNPFYKITDPIRSPAFDSRVRTLARKHLSK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPEDDATARFLAKYGVAKLAEQWCLAPEVCATLAELRIRSFFPVQAVAIPKLLASDSDRVTDICISAPTGSGKTLTYVVPIVQRLLPRVVCRVRALIVLPSRDLAVQVHQIVQQFCRHTPLKCGLAIGQSNFAVEQAALVGDISGDKVSSTTDGGRSLVDILVATPGRLVDHLEQTPGFTLQHLQIMIVDEADRLLNQSYQDWIAKVYASVFNGQEVDEEGLALGVGVTCRRQDSINRRRIRTPLTRVLLSATLTRNPRKLAAIGMSNAELTKIGRIDDPLADNAKLGTAGDSDEEDEEGEDASASNKMYSTPTNLDEFWIECDTGSKPLVLLELLSEFGGALSIVFTASVNSTHRLARLLQLYSSHPERIREFSSGLSQKQRSALVADCKAGRVETVVCSDAMARGMDIDDVANVVNYDVPSFIKTYIHRVGRTARAGRHGRSVTLVKMGQTKGMMRMLKKADSNKLKPYPLQQEHMKTLIPRYTAALQQLKDTLEAEKAGRIQATSVLRPNKGDASEGSTKVDAAAADDLDEQVASADKKRSFSVLGSQLERNLSHRKARKQ
The following text describes a protein:
Function:
Component of the CBC complex, which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus.
Sequence:
MSSYRGSTRPRKRTREGENYGFRPHRGNSQELLAARIKKDITFLADPRGNSVAADDINYVAMSLSREANDPETISTILDCIQTTAFIIPVKIPHLATLIIRASLRVPLILEKAAAYFCLQYFTNLNSFLYYEAKVDLRMLICMSFALQPGTLKPLFSLLADAISKETKPSVWGDNFLRIILINLPYFIAANNDLGKKDFANEILDQCEIYVRHRKSSITLSNPLSIHDNLSEEELDLLYKQLILSRENDFTFPYISQPWKFFESDFVHIVPVSPSIPEWTFQPTPQQNELPSFKRFFELFNNFEIRTTPDASDVAASIFRDISVDVINHLEFNRVEAAQVLTDLDVYFTYKTFALRGTPVNELPNLDPSESRWKAEDIIVEAVLGELLGSQNTTYKPVYYHSLLIECCRIAPKILAPTFGRVIRLMYTMSSDLPLQTLDRFIDWFSHHLSNFNFHWKWNEWIPDVELDDLHPKKVFMRETITRELILSYYTRISDSLPEELRCLLGEQPSGPNFVYENETHPLYQQSSQIIEALRLHKPLEELDIILQSEEIQNSETSAVRLVMSCAYSLGSRSFSHALNVFEKHLNTLKHFSRKSLDSEIEVVDELFSFWKLQPFNAVMWLDKMLNYSIISITSIIEWLIKQDVTIWSRSYTWSLVNTTFNKLAARLRRSVSNKEDSSLINEANEEKEIVTNLLLSALRALISENAENIWVSHWLNLMLKYVESNFLSVKKDTIEEANEPVQENTSEEQEDTKMQPVDAVDEQPSENNQTAADATNEEK
The following text describes a protein:
Function:
Acts as a phosphosugar phosphatase on a broad range of sugar phosphate substrates with preferential activity on D-ribose-5-phosphate, 2-deoxy-D-ribose-5-phosphate, 2-deoxy-D-glucose-6-phosphate, and D-mannose-6-phosphate and with a lower activity on D-fructose-1-phosphate, D-glucose-6-phosphate, DL-glycerol-3-phosphate, and D-fructose-6-phosphate.
Sequence:
MNGFSDLNPSESKPSLSQLAPLEAILFDVDGTLCDSDPIHLIAFQELLQEIGFNNGVPIDEKFFVENIAGKHNSEIALLLFPDDVSRGLKFCDEKEALYRKIVAEKIKPLDGLIKLTKWIEDRGLKRAAVTNAPKENAELMISKLGLTDFFQAVILGSECEFPKPHPGPYLKALEVLNVSKEHTLVFEDSISGIKAGVAAGMPVIGLTTGNPASLLMQAKPAFLIENYADPKLWAVLEELDNKS
The following text describes a protein:
Function:
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MEPVPLQDFVSGLDPTSLPRVLRVCSGVYFEGSVYELFGNECCLSTGDLIKVTHVQLQKVVCEYPETGQTLELNPNFTGLFSPLTSLRSYRTLEDLVSAMPQNSTRWPIYFKSTQRIVTKASVVPEDQPLRLEAVEIHHGIRYARCVQVSKTKELLHLPLSQKGPFWRCKPSAPQTLHQILQDPALKDLTLSCPSLPWNSVILKPQYMLQAIMHMRSSIVKIPSTLEVEVEDVTASSQHIHFFKPLRLSEVLAGGGPFPLTTEILEVPEGPPVFLSPWVSFLRKGQRLCIYGPASPSWRVVASSKSRKVPRYFMLSGAYQGKLKRRPREFSTAYDLLGALQPGRPLRVVATKDCDGNEEENPDFSFLAVGDRLEVLRSGQVCGTKGQDIDVLVCQRLSEQSGEEEEDLEEIEDEAEDKEQILLPLYLSGSFVEEVNDSRRYNLVDLTAQYSLPCEVKVVTKDTRHPTDPLASFPGLRLEEKLTEPFLVVSLDSQPEMCFEIPPRWLDLTVVEAEGQPAQVARPLSIAPVEELSEAFYYSLRKLPASESQAPPPRPPKSQGINKKQQNIQSCKESSVKPQVVEPQKSCPQPQLKAKTLEALPKNKSNVYSKISVHKKDRKPNPQTQNSVLSMKPKTSSSLGKHSTMESHLLPDPDMDDHDYEEI
The following text describes a protein:
Function:
Part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Plays a key role in coupling S phase to start and mitosis. Acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orc1, involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint. Together with orc2, plays a role in preventing DNA rereplication and resulting genetic instability.
Sequence:
MCETPIGCHTPRRCNRFIDSAALIDCTNKTNQREHSPSFSIEIPTTPSRKRTLASSHFQTPTKRIKYELGELQEEKTDLYPNFPAQLKENKKPKLPTTPQTPKTPKRTIQIVTPKSLNRTCNPVPFATRLLQSTPHRQLFPPTPSTPSTPSYNSTAKLSLRKSYRSAGVVGRENEKSIVESFFRQHLDANAGGALYVSGAPGTGKTVLLHNVLDHVVSDYPKVNVCYINCMTINEPKAIFEKIHSKIVKEEILENEDHHINFQCELESHFTQSANELYNPVIIVLDEMDHLIAREQQVLYTLFEWPSRPTSRLILVGIANALDMTDRFLPRLRTKHITPKLLSFTPYTAQEISTIIKARLKTAATTSEKNNPFTPIKSISEVSDDSINVVSQHADETPFIHPAAIELCARKVAASSGDLRKALDICRHAIELAEREWKAQHDNTLSSVDIPRASIAHVVRATSAMSQSASARLKNLGLQQKAILCTLVVCEKTSLSVADVFEKYSSLCLRDRLIYPLTSSEFCDVANSLETLAIIRLRTKQRNGKPQDRIISLLVPEMDVITAVGDIGTLKRFFDRR
The following text describes a protein:
Function:
Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.
Subcellular Localization:
Cell membrane. Cytoplasm. Endoplasmic reticulum. Nucleus membrane.
Sequence:
MNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQ
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAGTDSGFSHSKTLFQTQDGSPLIFYCIPGEVKTQIRPLVKHGGGLLTSRSRDENSIKLAEEGQSTRDCDTYSHRYILDCVEKNTLLPLEQYKMTSTAASSKASVTTSGKGRQKFLRSEQINILKYVAEHSDPTRPVGGNKIWKEMALYKITKHSWHAMRDHYLKHLKGKEHLYQLSDRLKYSRIQFRKDASPTTDDDGDKDAPRDAEEHQSEHSNKDDSINIDMFNSSDEEEKESGDPTEPTEVSSAQGSSAQATSAQGSSAKMTTAQATSTQGTSAKTTSAQATSAQATSSQASSAQASSAQATSAKVNSAQLTSAQVDSTLASTTLRRSPLKRRGKVTPVEEKTQGACGRSDGAGVQKESHEVPASSDDMDDHLAVLAVDVKKKQVKEEAILPEKRARLNPNDGKNGDIQDVKQDKHQQVGSDAVQEPASAAEAQEELREEDGMLEDEPRGDEEDEDHLLTVLEGCVKIKELMTEFSLSLLMVTRALYYHRGDVGATRTFLRTGKKTHVTPRPGWSSDIDEEK