lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MTTSVDKLNKLIEEVNNQDELQLIEEINLYIKTLYELRQVKIDQLSNIIHQLNQQIITSNKEINQLNKINDYNYELINVNNFNFVSQQSFQFTNFDRSSSSSSESTNNIFQMINKRLNELDNLKVVIVKELTDLETNLNNLKYKQNNLHESMEDINDKLDKLLNDMDKSGIMEQDPSILRINLFRNLGIKLENMPPNANSGGGGDSNSNSSNNNNTEEDCVIITDDNNNVNILNIEPKLSDYFISNYIWDKL
The following text describes a protein:
Function:
Major phosphatase responsible for tyrosine dephosphorylation of MAP kinases FUS3 and HOG1 to inactivate their activity; it also has important roles, along with MSG5, in the inactivation of FUS3 following pheromone stimulation.
Miscellaneous:
MISCELLANEOUS: Present with 768 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MKDSVDCPSILPTDRTSVLSETSTLVGSSSHVYSRHAPMNSYHNSMNSNIYHSPKASSPLVSYKTSSPVLLKRATAPVLPSFKPKEQRYNKPQGCSLITAVELGKIIETLPDEKVLLLDVRPFTEHAKSIITNSIHVCLPSTLLRRKNFTFSKLLDNLTPSEQSVLKSKLAIDNLRIIIYDSTANQTESSVSLPCYGIASKLIEFDTNVKKTVSILMCGFPQFKILFPDHINTNTFNSDCISSAEPKSPKTNLMNSLHNTAPHMTATTPLSSPQMNLKLKVPDDSRSDHSNFSSSPSPRNVLSDSPMSSSSPISALFKFQLPAPQTNINQMFKFSQNEEIMGLETYLSAVNIKEEHERWYNNDSAKKSLQNFQFPKNQNSLEKDTNKDKLGFQIRYENLSKNYEKEVIDSVIPEWFQHLMSIPKIELVSQFQKLDFLEKRRLNHSVSFRKKENSFILEKPSSYPEQLTSTSSSTIMPPKFPDVNKVQKRSHSQPIFTQYSKYKSMLSLESDSDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKKGLQSSKGIKHSHSTSDGGILDNYINANYLSLPRFSVEQNSSFQTTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKILKMPSTTSMRKNTMGTQNSSLYSAGVQGNSSNYSTDNDNDNDNNNNNNNNSNIAVTAAACDDDDDDDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQKEFVKLKYPAKLFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRLDDITERTDGDGSNKDNISLSALIEQIEKLEILQTFVDDKLKELPQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAEEESELELDRFKKELETLLKISASDERGLQSKTYCERFCELVVEHTGRWQVPLPQLQVLRSALCSFVQGVASFPPECEHVRYTLSSLALSIFELLLFFGKDEFIEHPLKDILDSFQVCYASLVSHQNVYLLQVRHIIKDGGPWASPVLEAILKDSELPQEDVDKYLSSEASIFFELRLRYLVACERLPEALALTRRCIQHSVVGKYLYYKQAYLICLWKAALHQCLNKEMADIDGKDAVEILCMMENEEKDETVLMLSKSFLSQKLQTGDMYYLWDLVFIWSRLYMRLNISKQGFLEECKVMILSATNIKAIFPFMKVVLTEFGKDGREFCVELCARALQTDLQNDPATKTLFYKTVAYLLPNDLEVCRACALLIFFQERTVESYKNVFLLYIHPDQQYHVDTGLVGNSVRFEVLQILKKDLYFDPEFWSILNIETNCLKLMSDKVGKAALCEIMQKDKWLPSYCVKGCCQCHSNDTDRTVSKAENHTSHIDQETTSMKMWVKFPSEDASSKTPSKKRGRKPGTRLVKNSDACPVRRSFRQLDLEKDYERKLNSRHQRRSRQTEMNTLKRKGRKPQWLLDQLAGQSENSEPRQVKKPGRKPKESHILREILLEPPVSEITVVFSYPDNEVDIAPNVQATQVSAETPHMTEKSTDKTSSLENLKWPHSALSLLELLSAESPPRSKKDLRMKDEFVFREQGPSMVRKFHTYSRPVELEKISFNSLPREQEAKLNHNESKEESVATEQLCEPAESPEVVEHVKQSVEIKSTPIPAITAETAPSVEAIREPVKECTEDPKVGEFSSPQDTDMQFPLYGPYSPISPPESTNVDNEPELSTPTISDTISAEGTSLTTAATISLSDSTPENITSLPEEAPPVLTEVAVLPDDTVANTYASSEIVPESTDMSVVPPRTKEITEMNAAVDDLVANRIPQSDTSCQLSVNCSYCNKEIKFPHILRHALWHHRIEKKCMFCHKRYAHGRSPSVHFKVHIQQLKQSNGLLNKNIPKKAAETSSQRVQKRRVKRGRPPIRNKLRNIKMRLNCTLNIADMHKDGQNSDQVRLRTRLVKNSDPGKATKEPKEKASKMKKRHLKRVLVKRPQSRDENKKLFRMRLEWKRTKTIQAPTPKDNHLESKSNSAPRVNGVIRKKRKDKSVSETNLSNEIAQTSVPHEIRVKTENVECSESQKGTEIQRDKESQKDIVKCQSENAGVIKDKIKSKSKRTIEMLKTVLKKKIAPEEQKEDGDAVKRRKISSPEVSSENQQPKDSNTVQKEVNAVENKNGTQKKSKVPSTPFQGKRTGASTQVKCPVEICTFSAKSILVLSHVLSHHLSDKKALVFFYDFGKEKCLYCCRKICNPQHFFDHVMSHRGELKFPCYHYGCKQRFRTRMELSEHVLVHLPLRAMCCFPGCSMQLQSMMLLYKHEKLHYEENPNLETKSILCKESEPLVHARLEDGMVAAAKSSVNQLTTTILKDSSSGKQDDEEKPLVLNKSSVNYSSKNHSLVNGHDETDKVVPQKPSDPVIKVQEAPAAKKQTNKQFIRPLPSSYLDESYTSMPKRWKELQVGSKLPGTVSIPEIPPTRQRCSRCFQSFDSEEELQKHKDKCTSLFGFDSDDESAS
The following text describes a protein:
Function:
Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Also has a slight blue shift for the far-red maximum. Forms a two-component system with the Rrcp1 response regulator.
Miscellaneous:
MISCELLANEOUS: The R form exhibits both ATP-dependent autophosphorylation and phosphotransfer to Rcp1 activities. Unlike the higher plants where Pfr is thought to be the active form.
Sequence:
MATTVQLSDQSLRQLETLAIHTAHLIQPHGLVVVLQEPDLTISQISANCTGILGRSPEDLLGRTLGEVFDSFQIDPIQSRLTAGQISSLNPSKLWARVMGDDFVIFDGVFHRNSDGLLVCELEPAYTSDNLPFLGFYHMANAALNRLRQQANLRDFYDVIVEEVRRMTGFDRVMLYRFDENNHGDVIAEDKRDDMEPYLGLHYPESDIPQPARRLFIHNPIRVIPDVYGVAVPLTPAVNPSTNRAVDLTESILRSAYHCHLTYLKNMGVGASLTISLIKDGHLWGLIACHHQTPKVIPFELRKACEFFGRVVFSNISAQEDTETFDYRVQLAEHEAVLLDKMTTAADFVEGLTNHPDRLLGLTGSQGAAICFGEKLILVGETPDEKAVQYLLQWLENREVQDVFFTSSLSQIYPDAVNFKSVASGLLAIPIARHNFLLWFRPEVLQTVNWGGDPNHAYEATQEDGKIELHPRQSFDLWKEIVRLQSLPWQSVEIQSALALKKAIVNLILRQAEELAQLARNLERSNADLKKFAYIASHDLQEPLNQVSNYVQLLEMRYSEALDEDAKDFIDFAVTGVSLMQTLIDDILTYAKVDTQYAQLTFTDVQEVVDKALANLKQRIEESGAEIEVGSMPAVMADQIQLMQVFQNLIANGIKFAGDKSPKIKIWGDRQEDAWVFAVQDNGIGIDPQFFERIFVIFQRLHTRDEYKGTGMGLAICKKIIEGHQGQIWLESNPGEGSTFYFSIPIGN
The following text describes a protein:
Function:
Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Sequence:
MILKEQGQIKPEVTATSPSIQNPTPLMDLEKSLQSHEKGKARKFFSRVSSRRRKGRRNYVKSAHVGALSDQVEAVDETACPLPSKTSSSSQSNPIAFKDNLAQVVIKESAEDSASQFEKERDSVEKGKREAPVMSIDDLGDRAENENCELLDNKILIDGKTDDSGIPTRETVVNLIVQHLSTVKIYCPKCADIYHPRSKYQDNIDGTYFGTTFPHLFLMTYGHLNPQGHLNPQKASQSYVHRIFGFKIHRP
The following text describes a protein:
Function:
Catalyzes the sodium-dependent uptake of extracellular pantothenate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNKILIIIPIIIYLVTMLLIAYKVNNIKNSSKSFTNEYYLGSRSMGGFVLAMTIVATYVGASSFIGGPGIAYNLGLGWVLLACIQVPTAFFTLGVLGKKLSIISRKLNAITIFDVLKARYNNSFLNVLASIMLIVFFISAIVAQFIGGARLFEAVTGLSYLTGLIIFSSVVIIYTTFGGFRAVTLTDAIQAVVMFTATTVLFVVILKNGNGMENIMMKIKDIDPNLLRPDSGGNIAKPFIMSFWILVGIGILGLPATTIRCMAFKDTKAMHNAMIIGTSLVGILVLGMHLVGVMGRAVIPDLQEVDKIIPILALKNLYPILAGVFIGGPLAAAMSTVDSLLIISSSTLIKDLYVTYLDKNTSESKIKKISMCTSFLIGILVFILSIKPISLIAWVNLFALGGQEIVFFCPLILGLYWKGANATGAIASIFAGIATYLTLEILKTKIFALHNIVPGLVVAIIVFIVASYFGKKSDEKTIKIFFEY
The following text describes a protein:
Function:
Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa RAP94/OPG109 to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters.
Subcellular Localization:
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.
Sequence:
MNTGIIDLFDNHVDSIPTILPHQLATLDYLVRTIIDENRSVLLFHIMGSGKTIIALLFALVASRFKKVYILVPNINILKIFNYNMGVAMNLFNDEFIAENIFIHSTTSFYSLNYNDNVINYNGLSRYNNSIFIVDEAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTPNTLGHIIDLMSEETIDFGEIISRGKKVIQTLLNERGVNVLKDLLKGRISYYEMPDKDLPTIRYHGRKFLDTRVVYCHMSKLQERDYMITRRQLCYHEMFDKNMYNVSMAVLGQLNLMNNLDTLFQEQDKELYPNLKINNGVLYGEELVTLNISSKFKYFINRIQTLNGKHFIYFSNSTYGGLVIKYIMLSNGYSEYNGSQGTNPHMINGKPKTFAIVTSKMKSSLEDLLDVYNSPENDDGSQLMFLFSSNIMSESYTLKEVRHIWFMTIPDTFSQYNQILGRSIRKFSYADISEPVNVYLLAAVYSDFNDEVTSLNDYTQDELINVLPFDIKKLLYLKFKTKETNRIYSILQEMSETYSLPPHPSIVKVLLGELVRQFFYNNSRIKYNDTKLLKMVTSVIKNKEDARNYIDDIVNGHFFVSNKVFDKSLLYKYENDIITVPFRLSYEPFVWGVNFRKEYNVVSSP
The following text describes a protein:
Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Sequence:
EKNMQKKEKDTCSKDETAVPKLPVPPLQQTLGMYLKCTKHLVPEEQFRKTKVIVEQFGIAGGLGETLQQILEERREKTTNWVFNYWLDDMYLNNRLALPVNSSPAIIFARQYFKDVNDQLRFAANLISGVQDYKALLDTHALPVDFARGQLSGHPLCMKQYYGLFSSYRLPGHTKDTLVAQKSSVMPEPEHIIVACNNQFFVLDVVINFRRLSEGDLFTQLRKIAKMAENEEEMLPPIGLLTTDGRTEWAEARTILMKDSTNRDSLDMIERCICLVCLDSPSGVELNDTNMALQLLHGGGYHKNGANRWYDKPMQFVVGRDGVCGTVCEHSPFDGIVLVQCTEHLLKHMKESSKKLVRADSVSELPAPRRLRWKCSPEIQAHLASSSEKLQRIVKNLDFIAYKFENYGKEFIKKQKISPDAYIQVALQLAFYRCHRRLVPTYESASIRRFDEGRVDNIRSATLEAFAFVKAMTDDKTALSESEKMQRFKDAIAAQTNYTILAITGMAIDNHLLGLREVAREHFKELPEIFTDETYLTSNRFILSTSQVPTTMEMFCCYGPVVPNGYGACYNPQPEHILFCISSFKDCKETSSDMFAKAVEESLLDMRDLCSKCNSTMAKPLAKQEADTQPQSDRK
The following text describes a protein:
Function:
Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro).
Subcellular Localization:
Cytoplasm, cytosol. Lipid droplet. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected on the surface of cytosolic lipid droplets. Recruited to the cell membrane by phosphatidylinositol-phosphate binding.
Sequence:
MNGEEEFFDAVTGFDSDNSSGEFSEANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKHRTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYGKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDCPDIY
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKKRTKSNKTEKKNNDITGIILISMGIFVLFSVFSPSASGIVGSFIKKVLIAVLGLGSLVFPILIIFTGCCFIGKKNKINLNSKFYGIVLFSINTLLFLQMILLKSYGTEDIMLGISKFYREDTMIHGGIISYLIDVPLYKLFGTIGCYILFICVYIISFILIFQVSLGTILQTLQVKRSIKNKKVKEKSIEDKEDIDGIEKELAPDLEKDEGLTRNIKDKIKILDFMKNSEIKEGPLNIVDNSVSENIEKSKEDTGEEAIKEELSKNINEGGNNVKIEYNYPTLELLKQNIQSKLNKQDKKELINNANKLEETLSSFGVEAKVMQVSRGPSVTRFELQPNAGVKVSKIVNLADDIALNLAASGVRIEAPIPGKSAVGIEVPNKSLTPVYLREVIEGDEFQKFDDGLAFALGKDISGSCVVSDLSKMPHLLIAGATGSGKSVCINTLIISILYKYSPENVKLLMVDPKVVELSIYNGIPHLLIPVVTDPKKAAGALHWAVNEMTKRYSLFAENSVRNIEGYNNLYDQGKIENKLPYVVIIIDELADLMMVCPNDIEDYISRLAQMARAAGMHLVIATQRPSVDVITGIIKANIPSRISFAVSSSIDSRTILDMSGAEKLLGKGDMLFYPTGSPKPTRIQGAFISESEVEKVVSCIKDEQGEAEYREEIIDQIDTAVNVEAGDEDELLEEAIRICIQLGEVSTSLIQRKLRIGYNRAARIIEQLEAKGIISGRDGNKPRQVIIDKNNETYGKYFRGNM
The following text describes a protein:
Function:
G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration. Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways. Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation. Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGPTLAVPTPYGCIGCKLPQPDYPPALIVFMFCAMVITIVVDLIGNSMVILAVSKNKKLRNSGNIFVVSLSVADVLVAVYPYPLMLHAMAVGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLAVTWTMTVMAVLPNMYIGTIEYDPRTYTCIFNYLNNPIFAVTIVCIHFVLPLVVVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPILFISGLITDAREMREARALARARARARDRARQQAREQDRARVEEVPMSVRNVPLPGDAAAGQPELASGHPKPASSHSRSASAHRKSASGHHKSVFSHSKPASGHSKPASGPSKPASGHPKSATVYPKPASVHFKPASVHFKADSVHFKSSSSHPKSVTGHHIPSGSHSKTAFSPDTSRPKPTSGPTKPAPTHPEPTTADFPEPVATSHPEPTISSQPELAASCHPETTAPGHLECDVTGLPEPASSPSTESSESAASSPEPATAAAPVDPIEGTTASSDYHEIEVLDVEADSDEMAL
The following text describes a protein:
Function:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Sequence:
MKFGSFATFAADIEATDADLDVVALVAELFDAADSDLDVVARFVQGRVFPAHSETKLDIGPQLCYTALSRAAGRNVDADDIEARLAETGDIGAVAGSLDLGGQTGLAAFGGGDDHADGLTVSGVADELAALAAAAGDGSQSEKVTLLFGLFNQCTSREARYLARLVLGEMRIGVGEGAVRDAIAEAFDVPTAAVQRALQVSNDYGLVAETARDSGTDALDAMGLEVGRPVQAMLAQAGTVTDALDEWHEAAVETKFDGARVQVHYDGDDVVLYSRNMENVTGALPELVEFVENNVTAPVIIDGEAVAADEDGDPLPFQEILKRFRRKHDVAAMREEISVELHAFDCLHAPSADGGEDLLDAPFSDRHRRLRSVVDDASAVSEVLVTDDADEIAAFEATALEGGHEGIMLKNPAAPYTPGDRGKDWLKRKPDVETLDLVVTGAEWGEGRRASVLGTFLLSARDAAGDGFETIGKVATGLTDEELAALSDRLEPHVRSEDGQTVDIEPAVVLEVGYEEIQASPTYSSGYALRFPRFVSVREDKTPTTADTIERVERLAAQQQQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes. Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14. RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17. Also involved in ubiquitination and degradation of stalled ETF1/eRF1. Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2. May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65.
Subcellular Localization:
Cytoplasm.
Sequence:
MRSLRPREGKSPVLGCRRVVEAGLEPTTWDSQAQTLATELLLALTPALSTLPGTKAPSLVIDSCLSLGDYLQWSRTASGTAADRPGRAPGPQRPRCLVTAPARCPRGPSCACAPRPFRPFSPPYPLLPARACAQLPPPPRPPAPAPAHPVLSTRPTHFSLPGHALPSLAPPPSAHAPPPSPAFLAALSLQPPHPCLPARACAPLPFPPHRLRMRAPSFPSFLPAPPVSPRPRLRSPPFPRLPRPAHARPFLPLLPPPPCLARACAPRGVGSGSGLRFRFRPGRPGEMAAAVSEAAEAAAAGPGAGDEDWVLPSEVEVLESIYLDELRVERGDGGSAAWEICVTLHPATAEDHDSQFVCLTLVLLVSPQYPDEAPEISIRNPRGLSDEQIHKISQTLSQVAEAGRGSAVLYELIEKGKEILTHNNVPHGQCVICLYGFQEKEAFTKTPCYHYFHCHCLARYIQHMEEEIRARREEEDRQQQQPPPAPDQGPAVQCPVCREPLAYDLAALRAAPPPQHPAEPYRPDADSLRRQRERQRLFRRQQRRGGIIDPEAERNRYFISLQQVRPPPSPGPGRRPPPPAPLRARLRTGPSPAPGPGPEPGPRSAPGPVPEKSLPRSRPGSSPAPDGSLSRSRARPGPAAVGPGPAPGSDGARGGGGGRGGLRPPPRPPPLLLSPPPPPSASRSRGARPRRGRPRGPPPGSRRRRRPAPRGAAGGGPAGGGRGAGRRDGRPLARPGVRAPAGRGDPRPARPRPPPQGAPHGPRGGGPGAGRGEGTPAPPELGLRAMGAVRGPRPPRLLLPPSARPGPGARAARPAPGAPRPGPGEIKSVGPAPPPLCSPRPAAPTTPAEGRGSSGGSPRSGRSTCPGTGPGKVHGSQGYGRATTVLPAKRPPGAPGWTAR
The following text describes a protein:
Function:
Mediates zinc uptake. May also transport other divalent cations.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPDFSMSNLAVAFSITLAAGLFTVLGSGLVMFSKTPNPRVLSFGLAFAGGAMVYVSLTEIFSKSSEAFAEIYDKDHAFAAATMAFLAGMGGIALIDRLVPNPHETLDAQDPSFQESKRRHIARVGMMAAFAITAHNFPEGLATFFATLENPAVGMPLALAIAIHNIPEGISIAAPVYFATRSRKKTVWACLLSGLAEPLGAALGYLVLQPFLSPAVFGSVFGVIAGVMVFLALDELLPAAKRYSDGHETVYGLTTGMAVIAVSLVLFHF
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.
Sequence:
MTWLQNITKESKIWIVNYACAIDYYVDLNKQKNSVLIPGGKGINVAIVMKSLGFDPTVITFLGQPTKNLFLELVKPYDLNIVSFISETKTRINLKLLKDEKTTEINDLSPLITDANLTELLTFLKANVKNNDLVIINGRFKFEALEKVLNLVFTLTENVVIDVDESKMLTLLNQSKPLVMKPNIDEFQTMINTFFHDQQSLIAAIKKFHYCKLLLLSDGDKGAYLFDQNKLLFVSSITPKQVVSTTGAGDTLLAVFLANLILKVDLKTALIKATNYASATISKLGVVDSKDKISVITPKSYYL
The following text describes a protein:
Function:
Has phosphatase activity toward PtdIns(4,5)P2, and in vitro toward PtdIns(3,5)P2 and PtdIns(3,4,5)P3. Cannot dephosphorylate PtdIns(5)P, Ins(1,4,5)P3 and Ins(1,3,4,5)P4.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MPTMGNKNSMCGLKRFPNYKKSPIGSFAKNSSSHDGIKTIEAVNSCSFSRKADLCIRIITWNMNGNVSYEDLVELVGKERKFDLLVVGLQEAPKANVDQLLQTASSPTHELLGKAKLQSVQLYLFGPKNSHTLVKELKAERYSVGGCGGLIGRKKGAVAIRINYDDIKMVFISCHLSAHAKKVDQRNTELRHIANSLLPRDKRKRDLTVWLGDLNYRIQDVSNHPVRSLIQNHLQSVLVSKDQLLQEAERGEIFKGYSEGTLGFKPTYKYNVGSSDYDTSHKIRVPAWTDRILFKIQDTDNIQATLHSYDSIDQVYGSDHKPVKADLCLKWVNS
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MQAIAFHKLLLLLPLAFYQSTNGMEWNYLKNGKDWEDLCSSGKHQSPILLDSRTARKWVLPGITFWHYYRLLKRPFYIRNNGHSISLDIPVTSNGRKPFITGGRLKGRYYADGLHFHWGSYKSRGSEHLINKRRFDAEIHIVHRNEKYRNIAQAVRQKDGLAVVAIMVAIVRKDNAKSTPLSRLMEAVVRVPIEDSNATVFGQSSLDQLIGGVSHRDFFTYEGSLTTPLCDETVTWIVFTETTTVTMSSVSKFWLLRDHWGHRLINNYRIVQDLNNRTVFYKKRMS
The following text describes a protein:
Function:
Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEREETREEAVRELQEMVQAQAASGEELAVAVAERVQEKDSGFFLRFIRARKFNVGRAYELLRGYVNFRLQYPELFDSLSPEAVRCTIEAGYPGVLSSRDKYGRVVMIFNIENWQSQEITFDEILQAYCFILEKLLENEETQINGFCIIENFKGFTMQQAASLRTSDLRKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKSKLLERVFVHGDDLSGFYQEIDENILPSDFGGTLPKYDGKAVAEQLFGPRAQAENTAF
The following text describes a protein:
Function:
May play a role in cell morphology and motility.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDEEEDLDERGQPDKFGVKGPPGCSPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVTGGPQGADLSVYAVTALPAICEPGDLLELLWLQPATEQPAPAPHWAVYVGGGQVIHLHQGEIRQDSLYQAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAWCRFGKREFKAGGEVPAGTQPPQQQYYLKVHLEENKVHTARFHSLEDLIREKRRIDASGRLRVLQELEDFVDDKE
The following text describes a protein:
Function:
Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (By similarity). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (By similarity). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (By similarity). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (By similarity). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Lysosome membrane. Note=When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR. Phosphorylation by MTOR promotes ubiquitination and degradation. Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus. Phosphorylation by MARK3/cTAK1 promotes association with 14-3-3/YWHA adapters and retention in the cytosol.
Domain:
The leucine zipper region is part of a larger coiled coil.
Sequence:
MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSSSSAEHSGASKPPLSSSTMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVAVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRHQVKQYLSTTLANKHASQVLSSPCPNQPGDHAMPPVPGSSAPNSPMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQELVQHQADLTCTTTLDLTDGTITFTNNLGTMPESSPAYSIPRKMGSNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRSSMSAEETEHAC
The following text describes a protein:
Function:
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
Sequence:
MLETCYSIRMRAAEKNLEGGEKHISGGERIGSEFQIEPIVKQLLNKARNHSRGDADFIQITVEKLTGDQILYMPPLEITTIDESSIERAHKEARSILTSVGVSKQAQNVAFHLLASNQNLRGAILLHSQTGLRLDNRGLKGVRVSRIDWQDADVGYNERVREALALATKVANSPYTIAELCWSDDPEYVTGYVSNHEIGYVRITPLKREGCESGGRIFFVSDEVELESYIHYLEREPILIRGHLK
The following text describes a protein:
Function:
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism. Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MATGTQQKENTLLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVTPGLLQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVPNSNVVHIFSAGSAAFVTNSLMNPIWMVKTRMQLERKVRGSKQMNTLQCARYVYQTEGIRGFYRGLTASYAGISETIICFAIYESLKKYLKEAPLASSTSGTEKNSTNFFGLMAAAAISKGCASCIAYPHEVIRTRLREEGTKYKSFVQTARLVFREEGYLAFYRGLFAQLIRQIPNTAIVLSTYELIVYLLEDHTQ
The following text describes a protein:
Function:
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFEISCYQESLAPCFCLSAHSNINQITEILLGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTNGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSGFGAKEACDQLVPDVNMEENLDPFFN
The following text describes a protein:
Function:
Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYSGLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWLVQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQTSTSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNVEHLKEEWNKSDQYWVKIYLFANLDQPPAFFSALSIKFTGRVEFIFVNVENWNNKSYMTDIGIYNMPSYILRTPEGIYRYGNHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTLGTYNSLLIISWLPVLGFLQLPYLDSFYDYSLRLLRYSNTTTLASWVRADWMFYTSHPALFLSTYLGHGLLIDYFEKKRRRSNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVDSDWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSESSQDTENDSDSDNMDTFSSSKDIFEDKQSVVHSSPGRTSHCDTEACSCANKCESSPCERKRRSYGSHNTDEDMEPDWLTWPAGTLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCPVCRWPSYKKKQPYAQQQPLSNDVPS
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MRFVYHPLAKEPVLKIEGESYTHLYRSRRVKSASRLDLRNLKDGFLYTYEHAEITKKHALLKLVGARLLEVMASKKTHLILSVIEIKNIEKILPFLNQLGVSKLSLFYADFSQRNEKIDIAKLERFQKILIHSCEQCGRSALMELEVFSNTKEALKAYPKASVLDFKGETLPASADFEKGVIIGPEGGFSEPERGYFKEREIYRIPLDMVLKSESACVFVASIAQV