lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse.
Domain:
The CD6 binding site is located in the N-terminal Ig-like domain.
Sequence:
MHSVICLFGAFIAAALFAPGSCLPTVIGLYGETIEVPCNNGNNKPDGLIFTKWKYAKDDGSPGDLLIKQAQKDDPTVSAMDGYKTRVSIAANSSLLIAQGSLTDQRVFTCMVVSSTNLEEFSVEVKVHKKPSAPVIKNKVKELENGKLTQLGECVVESANPAADLIWMKNNQALVDDGKTIIITSDVTKDPVTGLSSTSSRLQYTARKEDVASQFTCVAKHVTGPNQVSTPDTFQIRYPTEKVSLQVVSQSPIREGDDVTLKCQADGNPPPTSFNFNIKGKKVTVTDKDVYTLTGVTRADSGVYKCSLLDNDVMESTQIVTVSFLDASLTPTGKVLKKLGENLVVSLEKNASSEVKVTWTKDNRKLDKLPDFSQLRYSDAGLYVCDVSIEGIKHSFSFELTVEGGPRITGLTKHRSNDGKHKVLTCEAEGSPKPEVQWSVNGTDDETSYVNGKATYKLTVVPSKNLTVSCLVTNKLGFDTKDISVFSLFEEDKPKPGKNEDGADQAKVIVGVVVGLFLAAALVGLIYWLYIKKTRQGSWKTGEKETGTSEESKKLEENNHKADV
The following text describes a protein:
Function:
Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.
Subcellular Localization:
Nucleus.
Sequence:
MSDREFSSNDDLSLPKATVQKIITEILPPSSGQSFSKDARDLLMECCVEFITLISSEANDISEKEAKKTIACEHVERALRDLGFGDYVPDVLAVAEEHKEQLKSREKKQSKMEQSGLSEEELLRQQQELFRSATEKYHAAPEGTE
The following text describes a protein:
Function:
The beta chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV). Classified as a public TCR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers/individuals and confers long-lived immunity against IAV infection. Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains. Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).
Miscellaneous:
MISCELLANEOUS: The JM22 clone described as a variant of the public clonotype differs by one amino acid in the CDR3-beta domain.
Subcellular Localization:
Cell membrane.
Domain:
The complementarity-determining region CDR1 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex; The complementarity-determining region CDR2 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex; The complementarity-determining region CDR3 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex. Recognizes M/matrix protein 1-derived peptide mainly via its xRSx motif; The connecting peptide (CP) domain is essential for signal transmission in response to antigenic stimulation, likely downstream from ZAP70 recruitment; The TM domain mediates the interaction with the CD3 subunits.
Sequence:
MSNQVLCCVVLCLLGANTVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSIRSSYEQYFGPGTRLTVTEDLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG
The following text describes a protein:
Function:
This enzyme participates in both the breakdown and synthesis of glucose.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPHILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPTPAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPNGGPADTNVTKVVEDRANALLADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSGIEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFDGTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITARLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA
The following text describes a protein:
Function:
May play a role in mRNA degradation.
Subcellular Localization:
Nucleus.
Sequence:
MTNKEKPIKHLVIDTCAIIANRNLHALADHYYAPPQILDELRSSAARKLWNTLPFEVTLREPTQTALRAVIDASKTTGDFQSLSMVDIKMIALTYDLHRQYVAENDVAETTEDDEKKNIEDLSAKVEQVTVGENTEDTKEEEIEENEESEDSAVSEGSESSESSESFDEDGWITQDNIEETLKKLGAFEIEENMLVGCLTTDFALQNVLLAMNLSLVSLSGYRIRKLKSFVLRCRTCFSTTSVMTKEFCPACGHKTLHKCAVSVDEDGNQQLHINWNRMANRRGLVYTLANPKGGKHATNERLFEDQPMPHMRMAKIHMDPLADGPFSVHDVTSRSAMLGVRTINNRAKQNRNPNESKRGGRRK
The following text describes a protein:
Function:
Probable water-specific aquaporin that may modulate the water content and osmolytes during anhydrobiosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MAFMDKSEVRQRLQKVLQQCAKAPTWSPKEEVRQSIFWKSIRAELIGSLVLMVFSCSRDSIYGPVSYGCTYAILSYCFKSISAHFNPVITIAALLLRSITPFRCISLVLAQTLGTLSGASVCYYGLSNETETGSAPISPVLNVSPAKGFGYEFFGTFVIILTMSSYLDCNDYVSESGDSNLLPLIFGLSVGLSSGMARQATGGFLNPMRAFSLALFELNHWSNHYIYWIGPIFGCLLAVFTFDYTRPIIPNRDSNNRINFPTFNKNNKYEVEMQPETEITLATLA
The following text describes a protein:
Function:
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 or REC8 protein, forming a ring structure (By similarity).
Sequence:
MGHLELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDALSFVMGEKTTNLRVKNIQELIHGAHTGKPVSSSASVTIIYIEDSGEEKTFTRIIRGGCSEYHFGDKPVSRSVYVAQLENIGIIVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQFHFNVKKNVAAERKHAKIEKEEAEHYQNLLEELKINKIQLMLFQLYYNEEKINVLNTELEQMDGNLSVVKDTLSHHENIFKAKKKDYGMLTRQLQQTAKELKSVEAILNQKRPQYIKAKENTSHHLKKLDLSKKLITDNEKQCSKQEDGIRALVAELADLDRAWKSFEKQMEEKILQKGRDIELENSQLDRYKLLKEQVRRKVGIMTQQLEKLQWEQKAEKERLAFEKRRHGDTQGNLKQIKEQIEEHKKRIEKLEEYTKTCMDCLEDKKQQEEALKKEIENTKSRMSEVNEELSLIRNELQNAGIDNHEGKRQQKRAEVLEHLKRLYPDSVFGRLLDLCHPIHKKYQLAVTKLFGRYMVAIVVASEKIAKDCIRFLKAERAEPETFLALDYLDIKPINERLREIKGCKMMIDVIKTQFPQLKKVIQFVCGNGLVCETVEEARHIAFGGPERRKAVALDGTLFLKSGVISGGSSDLKHKALCWDEKELHNLRDKRSQLVQELKELMKTLRKETDLKQIQTLVQGTNTRLKYSQNELEMIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQDKIDEVEDDIFQDFCEEIGVENIREFENKHVKQQQENDQKRLEFEKQKTRLNIQLEYSRNQLKKKLNNIDTLKTTIQKGKEDIDNLKKTEEECLKIVEELMVKQEQIKEVLATQSSNIEKIHIQIEEERKKVLAVDREVGKLQKEVVIIQGSLEQKLLEKHNLLLDCKVQDIDISLVLGSLEDIIEMELTETESTQATADIYEKEASIQIDYSPLREDLKALQSDKEVEAHLTLLLQQVASQENTLLKTTAPNLRAQENLKTVRDKFQESADVFEASRKEARICRQEFEQVKRRRYDAFSQCFEHISVSIDQIYKKLCRNNSAQAFLSPENPEEPYLDGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQSQEQFQMIIISLKEEFYSKADALIGVYPEHNECMFSHVLTLDLSKYPDTEDQEGSRSHRKPRVPRVSMSPKSPQSR
The following text describes a protein:
Function:
Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.
Sequence:
MNKCIKPSSTAPSRSRLLGRRIKKKQSSRLGLGRSGTKQQVVKRAVVVEDWPLILVTGANGYIGSHVVLELLKQGEYGVIAIDSLENSSAESLRRVRELASQEKSLGAHHPPIYHHQTDIRDRRGMLAIFQGYRQRDGRNAIRHVIHFAALKSVEGSRLNPAGYYSTNVLGTAGLLEVMKASGVNSLVFSSSAVVYGSRAGRPGGPGHSSTDLLAESRCPVRAHQPEAERQANYARITNTYGKTKLMCEELIHKLCYEHGQSTNSEENFRAVILRYTNPSGNDPSGRIGDSPTYPENLMPIAAQVLQGTREQISIYGADYPTRDGTGVRDFIHVQDLAKGHLAALSAFQPKGNKFSRGMYPNNCQTYNLGTGKGASVMEVIQALTEASGRPIKTTIAPRRPGDLATVICDPSKAELELGWKAEKGVLEMATDLWKFCVSNPHGLLPLKASK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).
Sequence:
MEQFLKGLPKVELHAHLNGSLGIKSLCDLGERLYGTSCKDFLKLCAHFSRFEKDMDACFEKFAFVHELTSTREGLRFATELAIRDFAEDNVQYVEMRTTPKANENYSRRDYLQIVIDAIKAASETYPEITVKLLPSINRAEPVDVAEETVSLAVELARAHPNLILGIDLSGNPGKGRFSDFAPILAQARDKGLKLAIHCAEIENPSEVKEMLHFGMSRCGHGTFLTPEDIGQLKQRNIAIECCLTSNVKSGTVPSLEEHHLKRIMEADAPKVICTDDSGVFDTTLTKEFLIAAETFGLTREQCIDLTLEAVHHSFASEQEQIQMADRVGNYADILVK
The following text describes a protein:
Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Sequence:
MACLNLVNTATFGRFFTLRLFNRPFAHRHIKSLQYGLLGSCRTLCVSSTGVEKLTQSYSHGLASHPLIGDTVGQRLDKVAERFPNREAYVCYEDKERATFAELREEADQLAASLLSLGIKRGDRVGIWGPNMREWVISQFGTARIGVILVNVNPAYQAPEAEYALKKVGCKGLIMADTHKTQDYYNMMTHIAHELSDSSPGELYSNRVPDLRVLVVTTKDKNKKYGGAFTFDEFMKIGGEHERQQIRNMQMALQSDDPINIQFTSGTTGNPKGVTLTHHGILNNAASVGDILNYAEYTRVCIPVPLYHCFGMVLGSFACVTHGITAVYPSRGFDAGLALDAVQNEKCNSLYGTPTMFIDMLNHPKFEQYDVTSLRTGIMAGAPCPVEVMKKIITTFHMPEMTIAYGLTETSPVTNQTRRDVPVDLRVSTVGTMAPNVEAKIIDSEHGNVVPINTPGEICFRGYNVMQGYWDDYEKTDAAIDSNGWFHSGATPKAPVHPIHLRVSVAQVFLMKEGNKGRERFCDTLLLWTPMIPSLFIPKDVIIRGGENIYPTEVEQFLYKHPKIQDVQIIGIPDERLGEEVCACIRLHPGESSSPEEIKEFCKGQIAHFKIPKYIKFTEEYPLTISGKRSYVKYFIHTVVRSCVSEVIPQILYSHRGAQVRDAGTDDSRARPMTMDRQSDKIDILYAITPFNSRLRLVFTRQKA
The following text describes a protein:
Function:
Involved in the biosynthesis of galactosamine-containing minor teichoic acid, a non-essential cell wall polymer in B.subtilis 168.
Sequence:
MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVDSSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNALQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIGGTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLVDRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKSVLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERVLHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEVWGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR
The following text describes a protein:
Function:
Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
Miscellaneous:
MISCELLANEOUS: Present with 10900 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MVSLTFKNFKKEKVPLDLEPSNTILETKTKLAQSISCEESQIKLIYSGKVLQDSKTVSECGLKDGDQVVFMVSQKKSTKTKVTEPPIAPESATTPGRENSTEASPSTDASAAPAATAPEGSQPQEEQTATTERTESASTPGFVVGTERNETIERIMEMGYQREEVERALRAAFNNPDRAVEYLLMGIPENLRQPEPQQQTAAAAEQPSTAATTAEQPAEDDLFAQAAQGGNASSGALGTTGGATDAAQGGPPGSIGLTVEDLLSLRQVVSGNPEALAPLLENISARYPQLREHIMANPEVFVSMLLEAVGDNMQDVMEGADDMVEGEDIEVTGEAAAAGLGQGEGEGSFQVDYTPEDDQAISRLCELGFERDLVIQVYFACDKNEEAAANILFSDHAD
The following text describes a protein:
Function:
May be involved in translation through its association with polysomes. Could bind RNA.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MALLSRIRSSTSLFRHLNASPQIRSLSSASTILSPDSKTPLTSKEKSKAALSLLKSEKDPDRILEICRAASLTPDCRIDRIAFSAAVENLAEKKHFSAVSNLLDGFIENRPDLKSERFAAHAIVLYAQANMLDHSLRVFRDLEKFEISRTVKSLNALLFACLVAKDYKEAKRVYIEMPKMYGIEPDLETYNRMIKVFCESGSASSSYSIVAEMERKGIKPNSSSFGLMISGFYAEDKSDEVGKVLAMMKDRGVNIGVSTYNIRIQSLCKRKKSKEAKALLDGMLSAGMKPNTVTYSHLIHGFCNEDDFEEAKKLFKIMVNRGCKPDSECYFTLIYYLCKGGDFETALSLCKESMEKNWVPSFSIMKSLVNGLAKDSKVEEAKELIGQVKEKFTRNVELWNEVEAALPQ
The following text describes a protein:
Function:
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MATLKEKLIAPVAEEEATIPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
The following text describes a protein:
Function:
Required for the regulation of activity and recruitment of ubp4 to endosomes.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MNSFSSNEYSTEISTEALNNWQQLVEQRISLELEYAAKLAKLTKSIKAIKQCAPLNDLTKQVCVELMQCNKKHLEASRYFQTHVKEFMKEYVDRENKFSNETISKSSAAALMTSMENFILFTNPVYHNKLQVPSKSDMEIANSLKITQPAEKNSGTANPISAYSLEHAELDERNNQLSEALSMLRLSPFVNNYYPSYQNRKDGKSLMENRGVVLSVDTVTSPISQSPKKLTPTTSPINSTSLSFVDAKKPGSKWPSQYDFPKKTKSTEIPFKTLPSLNINNERELTKHKLPIVKPKLAVFPSNQATASTLQLAPPPVQAIPTLRNPVNLDDKKESLLKYYATHPTITPDGFPIFAYVRALYAYKATLPSEIDLNVDDTLVVLNRQKDGWWKGLVVSPTVGRIGLFPSNYIEELEY
The following text describes a protein:
Function:
mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.
Miscellaneous:
MISCELLANEOUS: Present with 2490 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MEPEDTQLKEDIKTTVNYIKQHGVEFENKLLEDERFSFIKKDDPLHEYYTKLMNEPTDTVSGEDNDRKSEREIARPPDFLFSQYDTGISRRDMEVIKLTARYYAKDKSIVEQMISKDGEARLNFMNSSHPLHKTFTDFVAQYKRVYSFTGQEIKKSKRTILDNCFERTQYWEFEKDKDREHDKLVELCKIQFAAIPWDKFTQVAKFSIPEDTEIFEGSLDLEQMRLRRVQTGIKLFDSIKPTNEEEKIVSDQGKQKGGDSKGKKRKIRAVGETRLKKSKK
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport. It can also use D-mannitol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MIETITHGAEWFIGLFQKGGEVFTGMVTGILPLLISLLVIMNALINFIGQHRIERFAQRCAGNPVSRYLLLPCIGTFVFCNPMTLSLGRFMPEKYKPSYYAAASYSCHSMNGLFPHINPGELFVYLGIASGLTTLNLPLGPLAVSYLLVGLVTNFFRGWVTDLTTAIFEKKMGIQLEQKVHLAGATS
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in the control of sugar metabolism and translation. Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis. This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis. Also phosphorylates the glycogen synthase GSY2 and the translation factors CAF20, TIF11 and SRO9.
Miscellaneous:
MISCELLANEOUS: Present with 2220 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MTYPVSAAAPADISYSKNTPLVGLSKPPCLYQHASSSVDSFSSTFSDDDRSDLVAVPNESPHAFSYNPISPNSLGVRLTILRRSLEIMVNSPDILHELKKKAPVIAYPPSLRHTRNLTETATLSASRDPLNGSLISPLVSNMPSPASRPVIQRATSLMVLPDNDTASKLNPAKSELENLLFLLNLALENNSFERASDLHMLSLLNIKKINFDSDIQKSETLKKVLLDSLAEPFFENYKKFPHKDLGSKSQYNEYEEKHDDIVSLADIKPQQDYSRILHPFTSAKNSGPEAIFTCSQQYPWNFKAANDLACLTFGISKNVIKALTLLDLIHTDSRNFVLEKIMNAEDDNQEIVFTGETIPIVQPNSTSNNNVPNLIWASLWAKRKNGLLVCVFEKTPCDYIDVMLNLRDFSVDSIIDTTHFLENFDKKKQQESTSPMTEKKTVKFANEIHDIGSVSHSLSKLIDDVRFGKVFSADDDLLPLSIRVANHVNEERYFTLNCLSENIPCAVTTSVLENEIKLKIHSLPYQAGLFIVDSHTLSLLSFNKSVAKNMFGLRLHELAGSSVTKLVPSLADMISYINKTYPMLNITLPENKGLVLTEHFFRKIEAEMHHDKDSFYTSIGLDGCHKDGNLIKVDVQLRVLNTNAVLLWITHSRDVVIENYTTVPSQLPMLKENEIDVVGSRGSSSASSKKSSEKIPVNTLKAMADLSISSAETISNSDDEVDLNQVNEKLRETSCGKVRGIESNDNNNYDDDMTMVDDPELKHKIELTKMYTQDKSKFVKDDNFKVDEKFIMRIIEPINGEEIKKETNELDKRNSTLKATYLTTPEANIGSQKRIKKFSDFTILQVMGEGAYGKVNLCIHNREHYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKNSQENILKLLDFFEDDDYYYIETPVHGETGSIDLFDVIEFKKDMVEHEAKLVFKQVVASIKHLHDQGIVHRDIKDENVIVDSHGFVKLIDFGSAAYIKSGPFDVFVGTMDYAAPEVLGGSSYKGKPQDIWALGVLLYTIIYKENPYYNIDEILEGELRFDKSEHVSEECISLIKRILTREVDKRPTIDEIYEDKWLKI
The following text describes a protein:
Function:
Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Involved in positioning the proximal bud pole signal.
Miscellaneous:
MISCELLANEOUS: Present with 5630 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MGRYSVKRYKTKRRTRDLDLIYNDLSTKESVQKLLNQPLDETKPGLGQHYCIHCAKYMETAIALKTHLKGKVHKRRVKELRGVPYTQEVSDAAAGYNLNKFLNRVQEITQSVGPEKESNEALLKEHLDSTLANVKTTEPTLPWAAADAEANTAAVTEAESTASAST
The following text describes a protein:
Function:
Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTSIFVGAPRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLLVCAPRFFVPKNKNYGQMRGICYWVRDTVADTPPLSDVRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAGNGAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPEQETITVTACYRLETTSKARQMQQQELTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHYTGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCAAHVCVSDLQLSSKDVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGNCRVRHEVMLCDLNGGRALARGDSESLTIIFDVTQLSGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPATDCEGNQEEINVEMHSDLEN
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPRLPPILRLLQAPEKYTVIPKARISSKPAKSPTSAMDQAVGMSVIIAGFMVPAGWVLSHLESYKRSSAA
The following text describes a protein:
Function:
GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT). Plays a dual role as both a protectase and a reactivase for MMUT. Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP.
Sequence:
MSAVFQRLKSIGIDHGKMAAICHSCRVKLGSSMLQTFPTAARCVETLINTGHFSALDIVPQSNLNGRGHIPQGNGSMCSCNSVSSHGEETLSYCIPKRNFSTLLPFHQAVSTKKNVQSSVSSSAPCSIKLCSKIRSAWSKSSQLKSARHLSMSSSDNHHETLNMCCKHPAVQEDRKQEEIYAQELSNALLAGERWALARAITLVEATHKKGKRQAQVLLRRVLDHLREVQLKNRGTPPSFRIGLTGPPGAGKSTFIEAIGKKLTAEGHRVAVLAVDPSSSITGGSLLGDKTRMTELSRDPNAYIRASPSAGTLGGVTRNTNDTILLCEAANYDVIIVETIGVGQSEYVVADMVDMLVLLIPPAGGDELQGLKKGIVERADFILINKADGELLIPARRIRSEYTSAVKLMYKRSPLWAPKVKQVSSKTGDGLSKAWDTMEEYRGIMMEAGQFTTKRQRQRRVWMWQHIKDRMMEEFKESQELLTEIKHWEEEVMAGRCTSGIAADKLLKSFSKLSRNF