lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation. Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPLQWERSLRNKVISLDHKNKKHIRGCPITSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRNDANLCDANKVQSDSLPSTSVDSLETCQKLEPLHQSLNLSERIPRVILTNVLGTELGRKYIRTPPVTEGSLSDTDNLQSEQLSSSSDGSLESYQNLNPHKSCYLSERGSQRSKTVDDNSAKQAAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKSSENYHQDPELPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTTEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESALLELPLITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLEHSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELCYPLSWVQAFPLFQNLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDVAKPTYTFLQKQSSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQQQKGSSS
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MIKFTCSITLALLLTVSSVSAAPKESLITSLPGFDGTLTSEHYAGYVTIDGSPGKKNLFYYFIASERKPSKDPLVLWLNGGPGCSSFDGFIYEHGPFKFHAGKPEGSLPVLHLNPFSWSKVSNIIYLDSPCGVGLSYSDNPKNYVTGDLQTASDTHAFLLKWFELYPEFLSNPFYISGESYAGVYVPTLASEVVKGIQIGETPLINFKGYLIGNGVTDEKFDGNAYVPFAFGMGLISSDIYEAYQTTCGGKFSDPPSETCQKNLEKVVRAVSGLNFYDILEPCYHNSETKNESENTNMPLGFHQMGMTKKPLPKQTRMFGRASPFWTTKDAGASSPGSQEEFHIECVDDEAAVAWLNDEAVRKAIHAAPASVAGSWWICASRVSYSVDTGSMIPYHKNLTSQGYRVLIYSGDHDMRVPFTGTQAWTRSLGYKIIDEWRPWMTDDQVAGYLQGYDNNFTFLTIKGAGHMVPQTKPREALEFFSRWLDGKPI
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MIKILRSLRQTNHKQSYGLFGWFKKKEEKVDDSAYDPETWKQLQPAFNKVKEENQNKPKLLPIKKKQYSDKLTVVMELDEVLVYSFVPDPKDMFMNAPLRQYDFYIDLPEFDNFVHVYKREQLDEFLEYFLNHTEPVIWSKGSRIYVERVLEKLCPQFPKDHIFCQEQCNLVEEDDLEDYFKDIDLLGRDRKKVVYVDAKPLSFWTTGDNSIPVRMFVADNTDTKDDLQKLMNILERLKQENDVRDYLKKIYKVEETLRETKFIE
The following text describes a protein:
Function:
May function as transcription regulator (Probable). Essential for larval development. Required for morphogenesis and function of the digestive tract.
Subcellular Localization:
Nucleus.
Sequence:
MTLPWNTFPGSTVPPVVPSVEDIIRMLVAGQQKIAIQNLLQSQSKEQVNGTSHDLQNWLTSLCISPSSSPTPSNASTSTIPAQMTNENVLHLQIQSQLFSNLGTPWFLNPEQHNKTNNAIRKRPKKEFICKYCARHFTKSYNLMIHERTHTNERPFHCETCGKSFRRQDHLRDHKYIHAKEKPHKCEICGKGFCQLRTLNVHRSCHHVQEPISETFMLGAIKFGKADSLLIDAEPLIDVTTI
The following text describes a protein:
Function:
Transcriptional repressor that functions with ULT1 in a pathway which regulates floral meristem homeostasis and organ number in the flower. Binds specifically to the DNA sequence motif 5'-GTAGATTCCT-3' of WUS promoter, and may be involved in direct regulation of WUS expression. Binds specifically to the DNA sequence motif 5'-AAGAATCTTT-3' found in the promoters of AG and the NAC domain genes CUC1, CUC2 and CUC3, and may be involved in direct regulation of these gene expressions.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Note=Localizes in cytosolic foci.
Sequence:
MVQTETDQRMGLNLNLSIYSLPKPLSQFLDEVSRIKDNHSKLSEIDGYVGKLEEERNKIDVFKRELPLCMLLLNEEIVFLCVAIGALKDEARKGLSLMASNGKFDDVERAKPETDKKSWMSSAQLWISNPNSQFRSTNEEEEDRCVSQNPFQTCNYPNQGGVFMPFNRPPPPPPPAPLSLMTPTSEMMMDYSRIEQSHHHHQFNKPSSQSHHIQKKEQRRRWSQELHRKFVDALHRLGGPQVATPKQIRDLMKVDGLTNDEVKSHLQKYRMHIRKHPLHPTKTLSSSDQPGVLERESQSLISLSRSDSPQSPLVARGLFSSNVGHSSEEDEEEEDEEEEKSDGRSSCRNDETKKKRQVLDLEL
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase.
Subcellular Localization:
Nucleus.
Sequence:
MASNKECLIIVLDVRTCAAEEVKLKSAKCVAEILKDKIVCDRKDYVSFVLVGCDTDEIKTEDASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALELQNVATTLRVARRRILLLFDFNDFPQDYEKFNEITDELLGENIELIVGTHNIAYIDNAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATLCSFKEALHTVFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAEKDEIVIRETRHYIKGTEITPLPENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHFFGFIKRNAVPDEYFCGESLYLLVHQKHNQSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQHHFWDFPALRTTKTECSEEQLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALPSIFEQNVMDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPLEEKSKRAAAIVKKLFPLRYSRAWQEKLLAKEQAENGVAVKSEPAEKEIPLPSDGVGLIDPISDFRRVLASVHTISNATERDARFQALAADTRVVIITLLQRRKQNIGQLGELITLYRQSCIDFNTFLEYDKFAEELKKIALAKNRSEFWQDVMVDKQLGPLVLGEPTLDDELALKAYYTIENWVESGANDMEDVEM
The following text describes a protein:
Function:
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. MSRA family specifically reduces the MetSO S-enantiomer.
Sequence:
MKVAKSNYFFSSFCFHFLFTIILLALNPVLSIRFPDRIPEVPQDASNQPLQTAVFSLGSFWRSEASFGCLNGIVRTTVGYSGGSKANPEYRNLGDHAESVQVEYDPQVLGFRQLLEVFWASHDSRQVFGQGPDVGNQYRSIIFTSGTEESRLAAVSKEREQSKSKSSVVITQIQQLEAFYPAEPEHQKERVESKALKNVLDDFTEFMSNQMLSKFELKRNPFLLQLMGNLPEEELERSTLATKLNGYAAELCSSRIQKRIDAKINDIIKKGWPILKEV
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEVFEKKINEVIGCIEKNVNCLDNFLSVRRDLSNDQLTCCKSLYDVCRALDGDDNRHEDYLPTLFLDDFNAEQVWQQIELVNKTWPSRLKHFVKNFKKSVKFQSDEKDAKVFKEDDETVENNSDDKDDDEEKEEDEDDDERDGDDNSVLGENDDDGGAVKEEEEEDEEDDDDDDEGCAIKYDDFYDAPPKPSAIDDFANMDDDGDDLDKASDDFGERGDDEEDVDMEEDDDDDDEEEEEDRLANDVNRELIRDESDNKQMVKSSFERRQEMLSKKINELEEKTTLEKDWQLKGEIGASKRPLNSLLQEVLDFDTATKPAMVITEEVNKTIEEKILQRLKDNIWDGPKRKIKTKERTFELKKAVAVLSDEKSEMSLEKIYEQEYLDTIQKKEEKVPLEIEEIKQSMAALFRKLDALCNFHFTPKPSMPEVEIVANNAAITMEEVAPTAVSEAMLLAPEEIADKSKKLIGSTERTKTNKKSDLRARKKRQHHIRLEKEEKQRIKKIKLEKKESLHKSLTDVHLKEKEKTKKGKNKKSSKSKLKLQKS
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC); Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MLDESAFLFDPETPHRFKSKEQDAVSVESASMSLFTDFKTFLTRYGSSVDLFQLVDSYMEVCEDNESLVRSLAGKLRKGPGLYRFEMADGMHKLMKQEKQTWRLISALYKDRQASATYDDENVFFFQANNISERKAVEKLFEVNSDVRQAQIVIDWLEQNAADEIEGEADRLRNYASAVSWENTLHRLNRNKEQGIEDPNLIYEMDPDAPTRLKREIDDLDREDEKQLLKIIFSFIRAGKIEEAEDLCVTHGQPWRAATLEGWRLHNDPNMNNDASEDMGLVPIEGNPHRDLWKLACWTLSSDETNNAHERAIYGALCGNMDAMLSVSSSWDDHLWAHYKTMVDMATERHIQQTANIMKPWQCVVKRVPLPDGYWKQNIDLGDCDLVFNKIENSNDQIVREESDNPYHFIQRCIILNDMEAMMDKCLEWLDDASMQLLRFLVHIILFLRTLGVHLQTEHCDKTIEAYVRKLIADGRTNHLVATYTAALPSELQIINYSAFLEAITDSNLQKEYLELALEAGLEIPAITKRVVESIRSIGGVNQTVAPDSSIELPVTIDDQRKIDSIEWLVFDPSQRCEALKQCNAVMRQFLASRKHEAAHDVFVKIPSDSIDILYNEWHAQADKDVPLPADADNAIREHLCMKAYLGAHTSFKEWFKHLHTSKPQEYQPTIHQTSTFGSVSIPELVAEEHRQKVSADKISAWDDKLRSLCDLVCDKIYNVLLFPQGWLMDMRDDGDSEEGEWRNHQMGLLRRVCIPYLSNLLLTVLVDTGGRYKECGQLANVLASEEYKLYELFTKQEGKEIMKRIQKALIKTL
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MEDFYTAVDLVANFDGKSQEEINASNNFLKEFTESPDFPAFAIQNYESCGTLLRVKFMNTKMKDIIKFHGSELPIEIIVAYKDLIFNQNSNFNGTNDQSFINILSESRVATIWHLYPEQWPSFWSDFLNSFSKRDVITFFKYFGLYSETLTYENTQLFTHIKDSMRADGSDLIVTKYLIDNLEPDHLDVFEALRMLLKWVSLVFVVNNESLTAIWKGINSKITCPETLNIFKTIVKRGMPDENRIAVLEVINPLQIVANVCETEIDTKIECAVAAFLCAAGEYAIQYQMYDGYYEMSLNFLRAANDNSVVSILPFFEAYIEVDPEKIPDILTEIIQRLSIFFENVTTLDSLDEEILEVSIHAAQKCLKKDKENVLNIFIQFIDMANFDDFSTAVSVLYVISSILKNKQLKDHINYLVGKFSPIVGLEFPCEVPLQEISYCIFTTYFLAVAEIFETDVITEVFNSLVRASTSEIDNEEVHERITNALFTLVKKNGNLIQFDPSLIHQLVQYKDGNIIATSAMLIQYMSGQQADFFQQCMDELLEIFNKTPESEQPDYLILILQFVRSMTYSPNSTHIQPVTEFLMNIMPFATQSDKLLSNFIRTVYASIEHYGLEILGLLIPVDKDTESYRELCLAIKALLNSKELTDHSWAHDYIQPLIIPIISIYNSITPLDWSNVLGDDARLKVEMTARFLEMIGVAIGNPDEHLIDQDNMTTILTMVQTALQNQYDHPSVIAPLISFVRSVVPLNPHQITQDFVGPTLCFIQSSKFRPDSKEWTAVVEAIIELHYRMYVSTEGQANDLIGQHLLEYYSSSGQDDILGYLEKISQTASNEELNRHRRKFGKQFYIRLSKFIKS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Subcellular Localization:
Cytoplasm.
Sequence:
MTETFTAVFEDLVEPRPIEHLGQSDLSYQGQLDPPLKIHEDGGESGCGGKVWIAGNLLCEFILEKSKDGRVLSQFPGYERQFKNIIELGSGTGLVGLCVGLHGKYNGATDTNVYITDIEGLCPLMQKNVELNGLDGMVHPRPLFWGEPLSDEFTRQPIDLVLAADCVYLEKAFPLLEKTLLDLTAGESQPLVLMSYKKRRKADKKFFIKIKKEFDIIEIKDFKSYEDYRRQRTYLFQLVRKPARAPHALAP
The following text describes a protein:
Function:
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity (By similarity). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (By similarity). Plays a role in the pathogenesis of invasive candidiasis.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.
Sequence:
MSYNNRSGGGASGGYSRRGYHGSHRGGYRTGRSKYPEDRYLVGGMLSLNKGSHYESSDNRYIPNEIGSKSPENRSHRSSTKDGRTPSGLSTPLSSSDKVSTPISIESINGSDRNTGVNNKDSEFPKLSHHSDFTSTIPFSRSINPQKNFMVINDSHTPKTDKGIQSKKIRYNGEGVNHVSDPRIAQSNSNLQKPTKKTKKTPYKQLPQPKFVYNSDSLGPAPMSTIIIWDLPISTSEPFLRNFVSRYGNPLEEMTFITDPTTAVPLGIVTFKFQGNPQKASELAKNFIKTVRQDELKIDGATLKIALNDNENQLLNRKLESAKKKMLQQRLQREQEEEKRRQKLVEEQKKQELLKKKEKEHQESVKKEKSVEHESTIVSTRDKNLVYKPNSTVLSMRHNHKIISSVILPKDLEKYIKSRPYILIRDKYVPTKKISSHDIKRALKKYDWTRVLSDKSGFFIVFNSLNECERCFLNEDNKKFFEYKLVMEMAIPEGFTNNIRENESKSTNDVLDEATNILIKEFQTFLAKDIRERIIAPNILDLLAHDKYPELVEELKSREQAAKPKVLVTNNQLKENALSILEKQRQLFQQRLPSFRMSHDRTQQHKPKRRNSIIPMQHALNFDDDEDSESHSQSESEDEDEDETTASRPLTPVVSTMKRERSSTITSIEDDIELEEREIKKQKVKVPAIEAEIAPESSPEEGEEEEKEEVEIKQEAEEVDIKFQPTEESPRTVYPEIPFSGDFDLNALQHTIKDSEDLLLAQEVLSETTPSGLSNIEYWSWKSKNRKDVQEISQEEEYIEELPESLQSTTGSFKSEGVRKIPEIEKIGYLPHRKRTNKPIKTIQYEDEDEEKPNENTNAVQSSRVNRANNRRFAADITAQIGSESDVLSLNALTKRKKPVTFARSAIHNWGLYAMEPIAAKEMIIEYVGERIRQQVAEHREKSYLKTGIGSSYLFRIDDNTVIDATKKGGIARFINHCCSPSCTAKIIKVEGKKRIVIYALRDIEANEELTYDYKFERETNDEERIRCLCGAPGCKGYLN
The following text describes a protein:
Function:
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The RGG-box domain is methylated.
Sequence:
MDVRRLKVNELREELQRRGLDTRGLKAELAERLLAALEAEEPEDERELEADDDPGLPGHNNEEVETEGGSELEGTAQPPPPGLQPHPEPGGYSGPDGHYVMDNITRQNQFYETPVIKQENESSYDRRPLDMEPQQQVYHPELKTEMKQEAPPSFLPPEASQLKTDRPQFQNRKRPFEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTIGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTVKRTDEEGKDVPDHAVLEMKANFTLPDVGDFLDEVLFIELQREEADKLVRQYNEEGRKAGPPPEKRFDSRGGGFRGRGGGGGFQRYDNRGPPGGNRGGFQNRGGGGGSGGGGGNYRGGFNRSGGGGYNQNRWGNNNRDNNNSNNRGNYNRAPQQQPPPQQPPPPQPPPQQPPPPPSYSPARNPPGASSYNKNSNIPGSSANTSTPTVSSYTPPQPSYSQPPYNQGGYTQGYTAPPPPPPPPPAYNYGSYGPYNPAPYTPPPPPTAQTYPQPSYNQYQQYAQQWSQYYQNQSQWPPYYGNYDYGGYSGSTQGGTSTQ
The following text describes a protein:
Function:
Dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A. Does not act as a receptor for angiotensin-2 (By similarity). Does not bind the VEGFA mature protein. May play a role in angiogenesis with a significant role in cardiovascular and neural development.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MNALYVTTVPKGYSSLSKCNHNEQDTAYRLWLCTHNHWTAPSGMRLQPLTSLGSKEMKSRWNWGSITCIICFTCVGSQLSMSSSKASNFSGPLQLYQRGIGHITNSYKRPQAPAWPCLSSGTMGRSH
The following text describes a protein:
Function:
Transcriptional regulator involved in resistance to high copper concentration.
Subcellular Localization:
Nucleus.
Sequence:
MVVIEGIKYACERCIRGHRVSSCTHTQQPLIRIKPKGRPATQCLHCREARKNKALHVKCKCGSSSSKHAATCPCYSGGGCICTNKHPQVLPPNSTTTGANGCIVINKAVLDEGSQQQAQQAQQQSQSQQAQQQQQQPQPQASPILQQPQMPTPVHTTNVTTPPVATPTHSHRALSTTPSLSPQPQSPHSPESALKSVNFLGRTNSSSSLSSLHSGRNKNRIEKVRPSHNSLSAASQLANSPSSPFYAVTPPAWVDSPTLVPTGALDASYLQILNDDLSSPLLDSDVFSSLDMEPVAHSNNNHGGIPTGGSRALASTDINFDRFESTSPSSILSSWNLWGGVGGSDAPEMSVAANPSASASASSIQTPPSSNATPEWVQGQQQPCSVSPADVMLPFKRDDQESVFLTEPLYL
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIARIFGYFEEGVLNLLITLMTLLVFTEVVARFFFDTGFLWIQELTLTLCGWFVLFGMSYGVKVGAHIGVDALVKKLPPNAKKITSLITTLICLTYCILFLKGSWSYLSQMYQIGVPMEDIHFPAWLLARLDPDWAWNVLKIDIEDGAVPIWISQSILLIGFSMLTWRFIELFVAILRNQVTGLSFADEAKESMHLIDDTAIQSQGPQHTTGAAHKELP
The following text describes a protein:
Function:
Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines. Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism. Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates (By similarity). Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK) (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MKRAPAFLSAEEVQDHLRSSSLLIPPLEAALANFSKGPDGGVMQPVRTVVPVAKHRGFLGVMPAYSAAEDALTTKLVTFYEGHSNTAVPSHQASVLLFDPSNGSLLAVMDGNVITAKRTAAVSAIATKLLKPPGSDVLCILGAGVQAYSHYEIFTEQFSFKEVRMWNRTRENAEKFASTVQGDVRVCSSVQEAVTGADVIITVTMATEPILFGEWVKPGAHINAVGASRPDWRELDDELMRQAVLYVDSREAALKESGDVLLSGADIFAELGEVISGAKPAHCEKTTVFKSLGMAVEDLVAAKLVYDSWSSGK
The following text describes a protein:
Function:
May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Domain:
Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
Sequence:
MYSSFAPHVRNYLQALLEYAVQNLKTTHAVRVISAGEGGPRDGTRQFCDRFKLLLPYAGQSVTWEVIFQAHRPEFPPDFIFDDMSFLPKIEDIPGLWDWDADDDGALVKVVFEMLDEYRKHQASLLDDFPRLQFEYSSLVHQSDIPETNIQVHLNRKNPGSAVRFWITLPVDFSRLPPVFTKENLSEDTAILQVTFQTPEGSRILPQLFLSPRVEEGLGGTMSLKIPAFSKDGCLMDYVPLIYLLSFFSMSNYNLLIVAILLLCSTFSHFHSLQKAVKKDLALPSLAAVSGARDLALPLLVAVSIPRSFPHDKPSLTFQSAYHASGGWPYTITCTDYPYSPRWDPGEMADRARIFVTEYVPNFQSSSVKNR
The following text describes a protein:
Function:
Somatostatin inhibits the release of somatotropin.
Subcellular Localization:
Secreted.
Sequence:
MTMGVKWDNRDVFHRSMFLMRVLLSLFPLVFVIWNGEALPIQDKQSQTNEILSKEEDGLKMITYVAELNLTSKELADLDAELLNGKLWEKSDKPSKDKSPCKLFFWKTFSSC
The following text describes a protein:
Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTLLLANDSIYGPNETIPLHHTPTSISSLVIFSLTFLLGIPGNGLVIWVVSLKMHRTVNTVWFLHLAVADFLCCLSLPFTIVHLVLHYHWPFGWLFCKIIPTAILFNMFASVFLLTAISIDRCLLVIKPVWCQNNRTVRFASGVCGSIWLLAFALCCPAFYYRETATDELGKSRCVYNWYGEEHLQETELDDLVFSHDLFSIQPPTGISQDYLTDGILDIYPKDQVLNMAENKSKAPHSRILDTAGIDQDTLMTDGIHPTSIFNFSQPQGNTATTNILHSDDPSGSFLESFSDRNNSMEIYDYDNYLSESQPPSVLVSITILRSVLGFLLPFGIMTTCYALLARKMLKNQFTKTRGKVLLVVLLVVATFFLCWVPYHIIGVLYLLATPGTEVFEELASWDHISTALAYANSCTNPLLYVFVGKNFREKVFQTVQGIFEGVFSEEATCSTACSQGRSQTRHDKFTDVSVL
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSLDLDWNLLDDQLSDRFLETINRALEASASKRPSFIGDIQFEKLDFGSDSPDVAIRSITDIWPDFVSIDEPPLRRRGARQTTPASNATTLVESPTDSFGVHHGGVGEIPLRTYTQFDDAAPPNRIHGPPSVVSASVAGSGPMTPAAAAGVANVFSQQWSTALASRGIRAAGMGSATSLPQTQVTSPVDSVPPSPGYFQHWQQHQQLATTGFVPYSVINSRQTSLDASSLRGGGSGPQSSVSQIGVKRDSNSLHPPLGGTYANGLGPRASMRATSAPSFRSISGQNSPGEEREAVASPSSASQLPSLQMRLSLVWPTTTFRLTITTSLLINYPSAAFMSLPLTLSVTGFMMRCGVIVALEGEHQRAHVCLVQEQDDERDPAFVSAGQAAAGSEKKLNSAGINILPQLTFESEVGQHEKHVLKNVGKVEKFIAEVIRKGLEDELVYPNYYTIDLPASKRHSL
The following text describes a protein:
Function:
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2. Stimulates DBP8 RNA helicase ATPase activity.
Miscellaneous:
MISCELLANEOUS: Present with 12800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSEKVNSDFEDFSSDEETDQHNVLIQTKKKISSKDDIFSKKVEDIESENESDIEEEQKQEEKEDVEQPDKENGEKLDREVEEQASSTTSLDLKTEKLRQLVKSKAAKKSKHKTGVVYFSSIPPYMKPAKMRQILTRFGEVDRLFLKKEDDQKYKQRVKGGGNKKNKYEEGWAEFIRKRDAKLCAETLNGNIIGGKKGTFYHDDILNVKYLPGFKWADLTEQIARENDIRQAKLEMEISQANKLNAEFIRNVEQSKMIQNIKNSRKRAGKEGESADSHPHREFKQRRVETSRANAPSDIKQQSSGSKDLGNVLTNLL
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Two genes for this protein are present in M.tuberculosis; this is the active form. When coexpressed in E.coli with nrdE the 2 proteins complement a temperature-sensitive E.coli mutant.
Sequence:
MTGNAKLIDRVSAINWNRLQDEKDAEVWDRLTGNFWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEIDDAFRWSEENRNLQRKAEIVLQYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLALVDDVTRAELKDYTYELLFELYDNEVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTEDDDWDF
The following text describes a protein:
Function:
Regulates both fluid phase and receptor-mediated endocytosis. Involved in vesicular transport at a late stage of the secretory pathway. Regulates actin cytoskeleton organization.
Miscellaneous:
MISCELLANEOUS: Present with 704 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSFDWLNVPGLDLSSGDQAEKRPSNGLGPPSVSFDFGINTAAPHDSSFWDQGSRSHSDTTLSYRNNHSNTAADNATNVSSPQKDNPPNGEVRTLSGGDVYAESPEDMQVPLSLSQNQLTHEEIRTYLRWYHYICLRTHGKLVRLNDVFRFLTNFNLSQKVKDRIVEIFRSCKNALNIGQFFAVLRLVSRAIIYGILPLRRMILEKAPVPKPRPILSSENHEEVYEEVEDDDSSAKTGDQKVDFDSFASLLLTGKTTRKRVRRRIKNLNFKSKKVRFSEHITFQDPPNLNQESSNNSEARKQDPDAEDEDQDSNNDSPLDFTLPMDQLLKRLYKRRKNSGLVSSLPSEQQETEEEKKVLEDMKDSLSHFKQIQTVDSASLPISSVFLQNGNTLPTSNVNNTTVPQQLPLEPLKPTATGSANHLVREEYNQGLHPSNGAIQTGLQPLKPTATGSANYLMRSHMEQPQSIKPSSTPETVTNSGGLQPLKPTATGSANYLMKQHISPSVNNPVSSMFQAQFTNQSSSPQSTGPAFLNSPNITLPQSNQQQPYQEVNPTQAKIEPSNISPQHTYSNNVRINNGNIVSMPKVEITGAFPPQNTLPQHQQSHLLSPQNTIPQHQRSQLISPQNTFTQNQPILSPQHTYSNNQATMISPQNTYTNNQQQPQHLPPPPPPRAQQQQQGAIVPPQHMYSNVQKQNNLVPTQPSYTNSPSIQSPNFLSPQNAANSYFQSLLSSSPSPNPTPSNASTVNGNNASNGISSFQNTSAAMNNTQSHQTYIQQQQQQQTQQRIYGGQLSQMQQHPGQLHLNNSDIHSQPNKPNYGMLGQQVHQQQQQQQQQFPFTADVNRSNSSDILGNLQSLQQQVDALQIQYNRRP
The following text describes a protein:
Function:
May be involved in proper membrane localization of Rab GTPases.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSYGREDTTIEPDFIEPDAPLAASGGVADNIGGTMQNSGSRGTLDETVLQTLKRDVVEINSRLKQVVYPHFPSFFSPSDDGIGAADNDISANCDLWAPLAFIILYSLFVSHARSLFSSLFVSSWFILLVMALHLRLTKPHQRVSLISYISISGYCLFPQVLNALVSQILLPLAYHIGKQNRWIVRVLSLVKLVVMALCLMWSVAAVSWVTKSKTIIEIYPLALCLFGMAWLSTIL
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MALDLSELEAELNRTRRKVQDWAASRVQLAAERKDQHFALMQDQTDKLNNLQGLKAQLQVATEQTSKRLSDEEAELARTQEAMASASSAVTTTEKRLEGGQLQLRRQQEEYRQRAAELEAGQRQKQKQLDSLRRATALFGERFSLKFRHGQDELCLVMTDVDAFDQGREFCISVRITDNVYSVTRCEPMVPGLDELTAEVNRTNDFATFVKSVRKAFVAVAKQAHGL
The following text describes a protein:
Function:
Gas vesicles (GV) are hollow, gas filled proteinaceous nanostructures. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition.
Subcellular Localization:
Gas vesicle. Note=Binds to the external surface of the gas vesicle.
Sequence:
MVSLREQWNEQARERQREISARKTETVALLQEANQERVRVAQQQKALAIELKNQLAQFHEQLETSVGNWRQETQEQLINLEETRTANAQQQREALFNFRRQLTADVWGETESDSLKVEENTPFVA
The following text describes a protein:
Function:
Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MADKPVPLAERRLMDVKLGHLPNWLTTRDFTPNGIFASIRRGHSAYFNKYINVKKGGIGGVAMLLAGYVVLSYVWEYDHIKHDRWRKYH