lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell.
Subcellular Localization:
Nucleus.
Sequence:
MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAILGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFANVEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEDDDQSKEI
The following text describes a protein:
Function:
Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology.
Subcellular Localization:
Cell junction. Cytoplasm, cytoskeleton. Note=In the intestine, localizes subapically and at cell junctions. Interacts with intermediate filament (IF) proteins and localizes to the IF network in an IF-dependent manner. In dividing cells, localizes to interpolar and kinetochore microtubules.
Sequence:
MSGPNGDPNISVDDGIIEDEDEFSEEEYAAIDSMLDQINSCLDDIEDRNDALNGKLHELLESNRQARKDFRQQLNDEEASPPPAEDPASRDTQTED
The following text describes a protein:
Function:
Has a dual function in uptake of nutrients and induction of host cell death. The N-terminal domain (NTD) forms an outer membrane channel and is used for uptake of nutrients across the outer membrane. The secreted C-terminal toxic domain (TNT) acts as a glycohydrolase, which hydrolyzes the essential cellular coenzyme NAD(+) in the cytosol of infected macrophages, leading to necrotic host cell death. Both functions are required for survival, replication and cytotoxicity of M.tuberculosis in macrophages.
Subcellular Localization:
[N-terminal channel domain]: Cell outer membrane; [Tuberculosis necrotizing toxin]: Secreted. Cell surface. Host cytoplasm, host cytosol. Note=Secreted into the cytosol of infected macrophages while the bacteria are still confined to the phagosome. Access to the macrophage cytosol depends on the ESX-1 / type VII secretion system (T7SS).
Sequence:
MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAGDDPAGAVFGRSYDGSAAALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAPPPSGCVGVGAPPSAVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRSAGTQFALTEIQSTAGPMGVIRAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDAYAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMADHAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAFGMAKDSWDLGPLRASIDPFGWYRSWEEMLTGMAPLAGLGGENAPGVVESWKQFGKSLIHWDEWTTNPNEALGKTVFDAATLALPGGPLSKLGSKGRDILAGVRGLKERLEPTTPHLEPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESKPPPVDRPAEPVAPSSASAGQPRVSAATTPGTHVPHGLPQPGEHVPAQAPPATTLLGGPPVESAPATAHQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQYGEPLSRHWDFTDNPADRSRINPVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPWGQQYSNFPPNNGAVPGTRIAYTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQRALHVTSLRDPYHAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIRRGVLRQ
The following text describes a protein:
Function:
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
Sequence:
MNLKLHHFTTMATTFFYFGFGSNMLASRIHIQNPTAKRIGVGKLENFRLDFHTGSKNWLGAPATIVPTQGSHVYGAIWEIDMCNLKDLDDQESVPAGVYVPISVPVHLLNTDSSITCRAYHLTNQPQTDLHAGGGQEIIPHDRQPSQTYLKVLVKGATESGVPDEYIEWLRGIKHNGKQVPAMEAKLELDKVQLS
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Sequence:
MNTSNIIKNNKSREGFKRNNNNNNNNSFDATSVKQLPTTSDELRYKHYFGEYLGYGVKIIDYEQGLDLYKHGSYGKGILSRSFPIFDNIKNSSITGSGFHIKKKDKLNNKRPRDFNNNNENQTTTTTTTTTTTTTTTTTSTTENTNVLEEERVIKQQKTTHLENQDNIKIDENKIENEENLLPTSTSSSPPNTEKVEYLQLSLCEAFYLIYSLGCLTILRRPNSSDKIIKTNDIDTNKKTMVKMTIQECWKEFQTIESSFISKYITYHYFRSLGWIPRSGIKYGCDYILYKLKPDLIHAQYGIIIQNRNEQSTNNNDNNNNNNGEINSNQPLFDESSGNRIIQSWDELSGINRVSESVAKGIIVFNIFKPKNHSEKFINRITELKSNNGDINKLNNRMNEKTKIEHIDLESLSDYKVNMWELKRWIPNRTRA
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAEENMDIEGEYGDQDESMYPISIKEYFIPWFVRVMHAIPRVDLSFEAVKSDFDYSSHKYKESIMFWIAIPILWLLLTLFLFLMYFCYRCCQQDPAIGIYGNEDTNKGVEHAVAAVKGIMLTVKKIKIKINSLTETVNTMLSQSLEEYFKTGPKSSDMMTRNEFENSVKQARETAKSFKNKFTENILQKFPKVEFCAFGIFSLVLSGLFTGIHLGVSVGISDVCINPDVVVEHYTADHVEQTTLAYYMRCDHYNAINPFNKIFMAANDMMVQTNYSLFQAKFRARDSNMAVNPANDPSELLFKSMQADLTKLQDIIITLTSLVDCTNVHKDYVELLEGLCHKTMMGVLLMLLSSLTVGLLFSLLVIISSKTWRVIGLSADEDSLKSYVDQDEEETGLFISSPHQQQPSSSSPSYYGYPKSRPPPPSVPLQQQQLQQSNIASYNRRTTPPPAYNSNEFYRQYSSSSNNNNNLPSGCVDNNLSSNPRLEYNIRESNT
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Sequence:
MRPPPPAALARAKSLQSDRLLGLLALAKRICCLAADIERIDRGAGRARIVPSFSFRNAAGPSGLHSSTLLLCDLMYPKVSALTCVRANKAVPPRIGLRQGFSQLRQLRLPSKNAASMQPRRYLQTRDASTAAVSAKLGDTHVNQHSGSSSFSQNHLPLSANSHLQPTPDHTSPFDDPAGKFSGSLNHWLSPWQAARRKVTHKDKQMKARITQVLDDFKADFAPGWRERSDTNGLNRRRLAAHRLWRVYQTYAHKERLPSYLRVNIANALVLSAHYITTNKSHSPQSKALRHLLGRRISAIIQDCNYVRAKKSPATASRSSSTKHLEFTVSMLQPISLALQAQPISALKLMDEVLLCSRPDVYSSKSQHNMQTEYLSPIHTTLLTILDSINFEVNCRPNAETLANSILSQPHFFEDDGMLADLQMGQEPPSESGNPIEKILEWIVESPHAFLFSHHYFRGARTLFFQCLSQARDPHHLLELLSRDRDPAQPGFLFACELLLRSVLRNSPEAALELYDDLWSRGIDLPDSLVQRLIKESGGQAPAARLEALLHRVTNTKSEGQARVSVKVLRSVAISWAIRNRTDRVMALLAHLKRRSTKGHDEFSQKVLAELAAARGDVQSLHEQLAEKYDFQARNVVGCAAGKVPLDGKAYALLIKSCNRSDDVDLAEFYLAEALERGIPLRPSDFNLVIDMHIRKTNVDAALAIFEQMKEFGAQPDTYTYTILIHGFALRRDPECAAHALRAMIAAHKTPDRITYAALLNCFVESGLYETATHLFAWMQGQRDVRIRPTIEVCNIILKAYVLSRLPVQKVMRFVDRVCKLGLLPNANTYALMMQSACDAGLMDVAEEVFSEAESALPNLAGAGIGQGANVYHFTIMIHGYLRLGNHAEAKDYFDEMQSRKLTPSAITWSVMVHSYAHSENEANYDLACNLVSQLVTDETKRIFRPSSWETSSTRTQLSKVQKADRVVSANKLAAKHSAPFETLYTVLMVAQAHRGEPENVEQTLQTMLRHMPRLSVPVLTPLLDAYRRAGDIDSALGLFDQIYESALRSSRSNSRRVYAYSQSDSDDAVEEQGSASQALNQRRQDASSRNQLCLPISIMIDLLSSAGRHEEIAKMWARAKNDGFGFDSDNWNHLAASMARAGQLEEALSVVEHVLYRNPPNAWMRSRLHADVRDHGAVSDAAGEAQVNELASGSDEEEPGESECLDRESQEAADFDFLPANTLLDPAVAHRPDATSAPADSLSRRHENRTDDDPYVDLPFERSEPSSAQEDASEPDPMRDLRLEESYTEPSAFYLDSSAKLPYKRDLVSNGDSFSPWYAHFATMEAISRGLANLREASKVITLLDTYRTAADLLDLHERKVEIIRERQKDEAVRSARDLIDGRR
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MKTVSGVKQLSFTPSIFKKITPEQYLSHLLNQDVRSDGRSVSEFREIVINDNCISTANGSAIIRAGENVFVCGIKAEIAEPFENSPNEGWIVPNLELSPLCSSKFKPGPPSDLAQVVSQELHQTLQQSNLINLQSLCIFEKKAAWVLYADIICLNYDGSAFDYAWAALFAALKTVKLPTAVWDEDLERVICASTLTRPVQLSTEVRSFSWSVFDDKLLADPTDEEEDLSTEFLTIMLNSSKNIVKIIKLGGTHIQPLLLKKCIEVARSKF
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nbp35-cfd1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MPLEGIKNIILILSGKGGVGKSSVTLQLALALTLQGKSVGVLDIDLTGPSIPRLVGLEGAKITQSSNGWVPVPVHEAEAQTASGNDAAVALSDDGGDENKDVERAKPRGSLRCMSLGFLLRDRGDAVIWRGPKKTAMIRQFLTDVYWGDTDYLLVDTPPGTSDEHIALAEELLKLSTTSPSSTGVGALPRLTGAVLVTTPQAIATSDVRKEVNFCVKTNIPTLGVIENMSGYTCPCCGEVSNLFSSGGGEVMAREMGVRFLGKVPVDVQFGALVEGKSQEESDDEDEDRERNKVEEEKGQDFVDERPLVERYKECWSYGQFEGFAKTLIGEIEG
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MTSFLSDSDDDSAAILPPLHQEIYEELCSGDEVTEEPVSSGFIGVPSVISEDQPLFTVIDYFIRQIYNYYTEIFVRLWPGLGHSERYVHLRGQWATSSISIADPCFIVGKWELGDDPVGNVYQNKYYTIIDDANGFFISLPHVLISGTEMATAQRCRRQTYINSVCPERISNMDMFRGSICHILLQRVFFGLRNQDIDHTLDQLLESSKYELFLMEETKESAKSTIIPYLETIRLIADAIETNSNKFTLDHRLFNGIATPIEALPPYGAKTVQEEENIWSFQWGLKGKIDATMEKEGIMFPFELKTGSSYNGQVKDDNVLQLSSYIFMLKERYKTQSAPCGLLFYMKDKSSFIIKPRRSELLSIVMSRNLIAHSLAHGSIPPTAGSSHICKYCPGQKICAFLEYDNDCPVKSFLNGKLSYTPNLRHREFYNEWDRLLVNEMLNSLDLQTQIWTSPVQKRISSGRALNNLHTNNGKSPIVTFYLNSGTIEKTQICVSNIVLITKNGIPPVIARGNVSAIEGNQITIEMIQSTMNEEEQDICLDLWESYNTVTRCRRNLMIMLTEDNQCCENLRNFIIENKSPVFTSLPKQTNISQENELNHDQMHAIKMALRAQDYMLLLGMPGTGKTTTLALLVESFEKNNQTVLICSYTHAAVDNLCSKLIDRGVNFVRIGRLESISEKVRSHCLDSIIESCENTEQLHLSLSGVKVFACTCYAFNHPFILEKFFDVCVIDEASQISMPVVVGPLTKCNRFILVGDHYQLPPISKNEGEVPISLFKMLSEKNTHAIVTLRTQYRMNNEIMQLCNELIYSNRMRSGFSSSAKNKIYFPNISILNEFSEYSKEWISRILKPDPSVLFVDTDSVPMREGKNMSSKNNVGEGSVVSMIVSAMILAGISTESIGVITPYRAQVIFIRKALQAQISCCSKYFPHMAGNPSEIASSIEVDTVDKYQGRDKECIIISTVKSNEKKSPGAHASDWQRMNVAITRAKTKLIFVGSRSTLENSPFFEHLFDLLSDNNFFSLPLSVNEGESKPFRSIDSSQSLSNIDTQDY
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
LKEVEGRIYSIAKDQYGCRFLQRRFDEGVAEDLQKIFEEIIDHIVDLMTDPFGNYLVQKLLEVCTEDQRLEILRVVCSGDELISISLNMHGTRAVQKLIETLKSPEQVSMITSSLEQGIVILIKDLNGNHVVQRCLQRLGNEENQFIFDAAAQHCVEVGTHRHGCCVLQRCVDFSKGVQKERLVGEIAANALVLSQDQYGNYVVQYILDEAPWIAPEVMAQLEGHHAHLAMQKFSSNVVEKCLKQGADDKRARIIHELTKSAFLGQLLQDPFANYVIQCALTVTKGALHASLVEAIRPHLPALRSSPYGKRILCRTNLKKA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLPRPKAPASPRRPQTPTPSEQDADPGPASPRDTEAQRLRFRQFQYHVASGPHLALGQLWTLCRQWLRPEARSKEQMLELLVLEQFLGALPSKMRTWVQSQGPRSCREAASLVEDLTQMCQQEVLVSLDSVEPQDWSFGEEEDGKSPRSQKEPSQASELILDAVAAAPALPEESEWLETTQLQQSLHTRAEAEAPRAPGLLGSRARLPLKPSIWDEPEDLLAGPSSDLRAEGTVISSPKGPSAQRISPRRRNRNTDQSGRHQPSLKHTKGGTQEAVAGISVVPRGPRGGRPFQCADCGMVFTWVTHFIEHQKTHREEGPFPCPECGKVFLHNSVLTEHGKIHLLEPPRKKAPRSKGPRESVPPRDGAQGPVAPRSPKRPFQCSVCGKAFPWMVHLIDHQKLHTAHGHM
The following text describes a protein:
Function:
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
Sequence:
MSFEHRDRMLEGIGWKARGDRIPEFPNPRPFFPRLKHSIKLIPLFVRVALHTFVEWWNGREAFIDIFNVFRHFTYTGVPLGGIGCGSIGTDFRGGFNRFSIIPGIKEQTETQKCNQFIVTVHSKKTFELIYQSILSCAEFPATVLPKWDTTIPAEDVRYRGLFPRAWQEFRLGSSGVTVVVEHLSPVIPGDYSDSSLPLANFEFHVFNDSYEEVEVSITMSFRNGTGNRKWNDENLCQSQKIQKDTMVVRTLAHTVKGMPVTYAIGTEEKNGSKVTTCLFDPNGTGGRLWSDLEAYGHLSSYDHLPSKPKELGIAVCSSFFVPPDGAHNTQFSLTWYMPQVHFGTAERFYNRRYCRFFNGPDADEVTAAICRHGLQNFSTWQKKIEDWQAPVLNDQKLPEWYKSAIFNELYYIVDGSTVWFEYDPDWKTEESLMSEQTEKQFKEYGRFGYMESWEYFMINTYDVHFYSSWAILKNWPQIEMSMQLDFADQMDRVDNNIATSLADGEQMTIKSVDRIPHDMGHPMADPWIHTNAYILHDTGRWKDLNLKFVISCYRDWKLIELGSEKGQVLEFFLGKCTKIVDGALECWDKDNDGMIENDGFADQTYDVWKMTGTSAYCGSLWIAALSSYIEMLKQSGLPTKHYEEKLEMAYDAYIGKLWNGTFFKFDELPENSKIVMADQLCGFWAMTAMDEPVQISKDKMKSALDTIFKYNVQMYNNGRCGAVNGYLTSERVDGSSIQSEEVWAGITYALSAMMIEKGMDEQAFKTSEGLFESIWHRFPLQYQTPEAITSDGMYRALGYMRPLSIWAIQHALDRRYRE
The following text describes a protein:
Function:
Acts as a transcriptional activator. Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MTGVFDSLVADMHSTQITASSTYHQHQQPPSGAGAGPGGNSNSSSSNSSLHKPQESPTLPVSTATDSSYYTNQQHPAGGGGGGASPYAHMGSYQYHASGLNNVSYSAKSSYDLGYTAAYTSYAPYGTSSSPVNNEPDKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPTEQHPGASASPPCASPPVSAPASWDFGAPQRMAGGGPGSGGGGAGSSGSSPSSAASAFLGNYPWYHQASGSASHLQATAPLLHPSQTPQAHHHHHHHHHAGGGAPVSAGTIF
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MKAYLTIAHGDNTLGTLRLTLRPDIVPKTVENFVHFLTSHEASGSAATTTTSGTTAGKVGGSGYKDSSFHRIIPKFMAQGGDFINHNGTGSTSIYGPNFSDENFLLSHSQRGTLSMANSGPGTNGCQFFITFKATAHLDGRHVVFGSVDWREDDESERVLDQLERVRTDRRNDRPVERVRIVDCG
The following text describes a protein:
Function:
May be involved in extracellular digestion.
Subcellular Localization:
Secreted.
Sequence:
MKEILGLASVILIGITLYMNGQSEISSQNQFQQWQSLHSKFYTQIEEQYRRMIFEQNKKMIDEHNANPENTYTMALNQFADLTTEEFVATYLDSQLSAGLKKRSVKPKSQSIPNEAYDWRNTTSVRDMKSGCISSWAFSTVGAAESYLTVVKSQKLSLSPQQLLDCDATSFSCNGGVPYKGLNYIADNGITVESVYPYTAKFSPCKREGGPYTINGNEDVDDLKSALRQYGVSVFVDATNWQFYSKGIFSNCEDNVNFAATAIGFTETYWIVQSSYGTSWGQNGYIYLAPGDTCGIESFGVRAI
The following text describes a protein:
Function:
Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAAPVRGMSLLRQACLGLVRPTGAQVCTQVPYRCYSTPGVGQVQVDMNSETGVATVRLNRPPVNSLNLDVLTELGIALEKLDADRTCRAMVLASAVPGIFSAGLDILEMYQSTPERCVAFWRALQDAWLGLYGSRLVTMAAIEGHSPAGGCLLAMSCDYRVMADGKFQIGLNETRLGIVAPFWFEDVMLNTIGHRETEKALQLGAMYSAQQALSIGLVDKVVPLAEVMPTVQGELKNWLQIPDAARVITKTSMRKQVLDRLRSQKEKDAQFFADFIGRDSVQRSLGAYIASLQKRKS
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MAAFSCFPLAARCCLLLTAALVLALSHGAHGYGDVGAGLSSSFYDDSCPSARDIVRRVIQNARVVDARIPASLIRLHFHDCFVQGCDGSLLLDNDLPAIMTEKEVLANDRSARGFKVVDSIKRALENACPGIVSCADILALASEISVELAGGPRWSVPLGRRDGTTTNIESAKNLPSPFDSLETLQEKFRNLGLDDTDLVALQGAHTFGRAQCQFTQRNCSAGQDEETLANLDTITPDVFDNKYYGNLLRGRAPLPSDQVMLSDPVAAATTARIVRRFSGSEKDFFKNFAASMVKMGNISPLTGRAGEIRNNCRRVNRKPYR
The following text describes a protein:
Function:
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
VVSTSSGGILPKPDKTPFGLIRMTAVVVPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD
The following text describes a protein:
Function:
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MSTKALKKKQHINVQHVNSSSDEGSEKKVVVVVNSVKPKFSMLNLSDEDDDKSDQDENEDKKDSESEESEEEEEEEEIEKEKPQAKEQLSSKQQKQKQQQQASKKKQAKKKQQQKKKQQQQEKDELELNEIEKSSPPIILSEIEIKDKEFRELFKINTVNLNPDNELKKLFGCKSSDIKGQKKKSVHHFKKKNYIFVQPKPEWPDVMGGFMVMEICNDDKVPSSPTNATTTTTTTTTTTNTVSPKLKSQQQSLDGINYFKIKWGQTYSNIQEEFYLALTTHDPMSLVEIIRYHPYHIDSLLQLGQVCLQTADYSKAGDFVEMAVFAFENVFHHLFNPLNGNCRFEYRHDQNKSCFLAIFRFIQIIGRRACHRTALELCKILLTWDYSDPLYVRLIIDYYSIRSKQYRFLVDLFTKLKTITPTNQGDLSLLPNFCYSAALAMYHLEREKSTTTTSTSTSTSSSKSSSVEESSDILLQKALISFPMVLQPLLEKLKTNFSIPKNGKIITLENDPFFKDDPLEKRIDHLVTLFVERNYQCWQTPEILDWLKSNVIIVLDKVAAKHPMVKQLSDSIKAEYETVNQEVFDHLVLSEYSDVINRLTPDIIEAMHAEGFRDILPQRDPNQAPPQHLRRGGIGQGFQIHQRNQQQQRRVQQQLRQLQQQQQQNLQHQQQQPLEPLLQENPDYTGPANPVLNFLHSLLPWNDPSIQRERQLAATQGTQQPAPGFLDDYVDFSDEDENEN
The following text describes a protein:
Function:
Collagen binding transmembrane protein involved in collagen secretion, probably by recruiting the ER-to-Golgi transport complex TRAPPIII. Required for normal development.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane.
Domain:
Possesses a PapD-like (PapD-L) domain similar to bacterial PapD domains involved in assembly and secretion of bacterial pilus components. The PapD-L domain can bind collagens and is essential for collagen assembly and secretion.
Sequence:
MVPSIHKTSNRYRTIYFFLISLLITSTFADQQAWPLPEEVSASQLHEIPVLHTAFVQIGEELHYLNHPIRPENVHQLPVYDSIKGVCEGNCPKEANKNHATKTFNVLKLSGKGKLPMEMDPPMMDFGQNSVGTAQKRKIYIRNMRNEQIFLDAVVVNSIEFQASYFEQYKLEPHGVTSLEVVFLPREIGKRSTIVHFYTSVGVFTYKMQGNCDSNPYRISPFTGYRLPMNSSISKPIVIFNPYAYTMRITEIGTSGGNAHIELPHEVDSKLAEEPLQYWDIRPYQSKQIATLVLVGATSENSTVFVRIGSEIYLSSEHRKPNTDIYLTVPIEVLKRRGVYATDEILDFGLIRQGMKSEAKVFSVVQYQIGGRLEFETLYVEKGDHTAIYMEFASHPPIIVYPPTKGSVTLGPKADLVKVYLEGNRVQMSPQQQMKHISGHIIAVSRGGNYNVSIPYRADVFRGDLLPIGNDLSIQEDLRPPHQRIIRIENQLPFDVAIFNITLAPELVSHFSVRLIDRTALIRSGHISPVFVLKYNKKLPPTFDNSTIYLHTNVSTFNLSLSTYTGRMNVELISVDKNSFDFGFVERNDTRTIRFVVWNHNRAEMRLKNLAVPHRSAYRLYEVGVKSIGNFSDVRNDERLEYVEATDVDIPPMKGKIFDLELKVPSDGVVRNGNIIFETDLESKIFGVTYQVSTGSLQSIPEEICFGQTFPSKLVYRTLQVFNSFDEDMTVTRLTTLNEDPRFFFEGFDPKNPPVLRSGRLTNLGRVMFSPSAPCEHDYCYLGLPLGSSDGAWFTHGLTLPSNLPEIDSYLYKQLRKKYDALVNSGKHHINTTIILDTDKAKNIKIKTSAELVWPRLLTRNSIHFPLTALGNFTIVNLTLANPTNVPVAIQVIPLVIYPDAESLVELMRPNLVSELTDHVEMNETLMFSLRDTELFTLKSDSPVPKLREAFEYHLNHEMPRYNNEINIPRFTLSMILKPHMKIRLRLGFLPSDYTLRSSLLLIRNNLTAIEPVVMYGKGARIGVKVEGAEARSKKPLLFEIRHDHLTDCNNPKRLMHKLHSTLTVRRPFQVMNSGEVQFTVTNMSINGVPCENRGFRILNCYPFRLQPNETYALDIAYTPDFLTTTNEADLQLYMHMNGSAWIFPLASTVPGDMLAKCHQALPRPPFENIMYYSCVTALIFCLVCVLACAYLEGDRAIAVAIRQQFAIPRHVFDLNNLNKNNSTTTPVPTVPSTAKPESSIKKPTPATRPSTLRASSDAWLISRLLIGLANFIVKCVHLFWKWSLFWRREKADDKQSKSAKVTKKKNPVTMQKVEEFRQMLEYVGQQKRQQNSGELAPEFDEVEEEELAEMWAQRKDSGAQSSVVTDPEPPMSKSQRKKKRAAQQKENNNLEAPIIVQPVVQSPPVQNKMEPAKKTTPGPSPKPKGNNQRKKHVQVPPVTKTPVTPKTSIPPPTEPEKPIKPSEQKKPNAIPVERPKQPTPSKARTPSKTPSQSNRAQHPASSPAPIAPTSAPTDDFVHVPPTSLTSPDLFYRQFLSSMGMPMDAGMWDTPAAQAAMPFMNLWNYGGPLSAEQMEDLIRQASGVAPITNDSEGTTVTTPSDIGMTWGTSGHLGGDEESIGGEAAPDWIDEDVNVDDAEMDFSSMSAASKDIFKDDDIDNFNQQMKRQRSPSQASSTLSRKLENSPQKMGSRRLTIGSEKKNNQSSSSALNPNYDFTRTPGNPNRMQMSQNSIQPAPPATSIWGDNSNSDPWGTNTVSNPLSELEDDPLSLSHLGINLASTESSATGPMFTMFSGPEFNLWSSSSLFHPPTQQPSTSQMPQDTDNENDEKNN
The following text describes a protein:
Function:
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MALNNRNCEFLALSNGNIPSKSLPTANNGEQQHPSTDEGRLKVSPNGCLSHNGVDKPCSLFLDNQRISQCCQPCSYHHSLHNHNNPQDCVPRTGGTANSALNSGCLQPRTEFSTDSGCQNHPPIYHPACCLQPSQSFCLHHWRDHFQHQQVPHHLVNLRAAKPFQLPKSYAALIADWPVVVLGVCTVIIVVCALVGILVPDLPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKNHHDDRWSEDHYEREKRQADWNFHKDSFFCAVPNDHYSRVVFTSVDGENLWNLRSIKSMCSIDNSRIRSHPQFGDLCQRTSADSCCPSWTLGNYIAILNNRSSCQKIVERDVSHTFKLIRTCAKYYHNGTLGADCWDMAAKRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFLSPKTAEYAVPALKHSMLFSPTEKGESMMRIYLDNFENWNCSDGVTTVTGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLVVMCVYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSEIVSTTLQHAALSMFVTSFTTAAAFYANYISNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLHDIFSCFKSPQQRQYNKTSCWNVLYQKAHDLLFMFSEASRIFFEKVLPCIVIKFRYVWVFWFLAITVGGAYVVCVNPKMKLPSLELSEFQVFRASHPFERYDSEYRKLFMFERVHHGEELHMPITIVWGVSPEDNGDPLNPKSKGKLSLDSSFNVASPASQQWILRFCQKLKNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPSLYPCCSQSSFPYKQEVFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFPSTYLFTLAYEKMHHFYLEVNEWIANELQSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMILTTWNIILSIYAIFSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVVFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCVSWAFATFFFQCMCRCLGPQGMCGQIPLPKKLQFKAFSQALSSNTTEMGPNKLNHTNKYQLDTRSTKPDVEHEHYELEPLASHNCSTS
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
Sequence:
MILEVKMSRIRILDESVSNAIAAGEVVENPTSMIKELIENSLDAGSKEIKLEVWNGGRDISISDSGCGMSKEDLLLSIERHATSKIFTKEDLFNIRTYGFRGEALSSIASVSKMILSSRTEDMQNGTQMNVLGGKVTNLKDIQKNVGTQIEIKDLFYNTPARKKFLRKENTEYLNIKDIFLREALANPNVKFILNIEGKESIKTSGNGIENAILEIFGKNYLKNFSKFSLGYLGNANLFKANRDSIFVFINGRSVKSKIVEEAVIAAYHTKLMKGKYPTALIFLEVEPSEIDVNVHPSKKVVKFANQNAIFDLIKGEIENFFTDDEDFISPYIEAENEVEENTKNNFLDINDFKDDMQDFLQLSVVGKEVYSKKDYNNIKVEKESFTDINKKINTFGSAGTTTESIINLNEIKEDSKNIENFDNSREINDKVKDKYIFNQEDTGRGKIFDDFTSLKNIDFKVIGQVFDTFILVERNGLLEIYDQHIIHERILYEKLKQEYYNHSMSKQNLLVPIRFELDPREKQLALENIEIFSSFGFDIDDFDKNEILLRSIPTMNLRDSYENIFREILDNISKNKDVDIRENIIVSMSCKGAIKANHKLTIEEMYSMVAKLHEVGEYTCPHGRPIIVKMSLLDLEKLFKRK
The following text describes a protein:
Function:
Bifunctional enzyme involved in flavonoid metabolism.
Sequence:
MANGEGEVVCVTGGSGFIGSWLVSSLLDRGYTVHATVKDLNDEKETKHLLGLEGAESRLRLYQIDLLDYDSIVSAITGAVGVFHLASPCIVDEVKDPENDLLSPAIKGTSNVLTASKELGVKRVVVTSSVSSITPNPNWPADCIMNEDCWTDIEYCKQNGVWYPLSKTLAEKDAWKFAKEKDLDIVVVNPGTVMGPIIPPSLNASMQMILRLLQAMELCCWCPQHALSLCLYSGCTDTYKDFFMGLVHVKDVALAHILVYENKSAKGRHMCVEAITHYGDFAAKVAELYPEYNIPRLPKDTQPGLLRAKDGAKKLMDLGLEFIEMEQIIRDAVESLKIKGYIS