lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MRLEIVECVKNEHAAGETLTFQLSEVDSSFANALRRVMLAEIPTLAIEYVTIRQNTSVLPDEMIAHRLGLVPLFSEKAKRLNFPQDCGCGGSGCPDCQITGSLKVQCPPNQHSKQVFIGDSLQIDDAEVYPVSAEEHGIWLVTLGRSQVLDLHVVIRKNIAKTHAKFMPVATVAMRYAPEIILNPNGFQTLGKAKAREWVARCPRNVFRFVERTGQVEVQDEDACIFCRECTSQEPPFDRLPEPLVFVRQKKNKMGYFDFTFTVESTGVLPVLQIVYDAVAVVRKKLQRVSEGLMKDPNTDGVKTRTIGQSTTAPVVPNADAVRKGAEEDNLDFTMQ
The following text describes a protein:
Function:
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Subcellular Localization:
Nucleus.
Domain:
The coiled-coil domain mediates oligomerization.
Sequence:
MATVNHTNCNTASPAALEEAKTSGGLRSPQIAHEPHDFGGSQLLPSGQEIQSEDEGTVPAGDGSSCNIRGSRTQSPGGCSVEAVLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPLAPYNTTQFLMNDRDLEEPNLDVLHGPSHSGSGGENEAGDSDGQGRAHGEFQQRDFSEAYERYHTESLQGRSKQELVRDYLDLERRLSQAEQETRRLRQLQGCSSRQPCQQVEELAAEVERLRTENQRLRQENEMWNREGGYCDQEKPASEGTPWPKVEAPFQTHTGQLGHREAGDR
The following text describes a protein:
Function:
Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity).
Sequence:
MSLNLPNPSLIGILLVISTHSGPQLIYKYPFDLSNDPSRDESKYALDDNEDDELYDHEESEDENEVNENEMYGVNSRNWDSKHIDYYMGTKSDLLKFLDEQDSRRRKITTTSPSEEKHTKEKHGLTKTISKSSTMASSSTTSPPESSIQGEIFGTDAAYICEMLAPPKQMCNTRFEMTIQDKLFLGLPVHRSDNGQWRSIGHNNEHDEEETHTAKNSLNMFHLVFVMNPPVIESNYRVDEMFHYVISRLSLVLRYEQQKHDYVSQQVKNILALRESLEGNESLLTEKSSLSRVIRDCFEGISTSTIANLSINGKLRSFQIPIKTEFHSLPDPSVPFLPASYLSSTVELLGDTSFINVGETSRYGHAFNSVQDEENSAEKIIVYFALLLLDDPESIIKDMKTETDSTLAKFIRMIEPTESLLKLSARNSKLDISQIKDFAFHLIYWRRARVILPLSSRSVYIVSPMAPITIKLYDDISFFNRRFPTLPSLPHFLKLLSPQSRKPQQFATVIPSKDHRDRYLQALGWLIKHGYVTQLQTFIWLKISRKIKIKVEEDIENENLAKKKKKQKNGSVTVATANSSKTEAPIMPTDNTSKQVSDSKDSDKPEDDEYASKPRLDGLHEHIDGTPIVTLVQGDDTIILDPGRATTLERRWINKIIYEECKLSPELTAVFYKLLKYMNGKNSLELLLLKENISRSELRKLLLSIEEHIISVRHW
The following text describes a protein:
Function:
May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).
Subcellular Localization:
Cytoplasm. Membrane. Note=Colocalizes with MYCBP in the cytoplasm.
Sequence:
MMKKITERQSPLKLLEKKRAKAPEQPTPPIQEEPEPVSNVLQGDDILALAIKKEDLRKQHVPQFEETGEKPVVTQKFIIRKLKPKDSSKRVYHLVAHPATPDAATKPLDYSGPHDSFLSSGQILPHQILGSLQDFKRIAVARGNTQLAKLIHIQPCLMTLISAKEEPKPKPPKEEERPSPWAPPPQHNFLKNWRRHIALRKKQQEALSKHLKKPASELLMHTGESYRKIQEEREVIDRALPTQHDGKATSWFWSPLEYLGDEMTGLLMTKKKTQRGLVEPITHIRKPLSIQVETGLPAQKDAWYRYTWDRSLFLIYRRKELQSIMAELDFSQQDIDGLEVVGHGKPFSSVTVEEHLPPEKIQKSSSEDTVFLDSLTNLSDMVPMPILGPSLLFCGKPACWVRGSNPEDKKNIGIGVRLTFETLEGERTSSELTVVNNGTVAIWYNWRRRPHQDFFQDLKQNKTQRFYFNNREGVILPGETKHFTFFFKSLNAGIFRESWEFGTHPTLLGGAVLQVTLHAISLTQDIFMDERKLLETKLAAHEAITIAQSVLQDLLRGISTPERTPSPVDAYLTEEDLFNYRNPRLHYQHQVVQNLHQLWQQYRKAKATQKETPSLRTPVPLLLVEKASGSISPRNLVSEYSQLSPHQEMDTARKTRDFFLSLKSSIGKKSVARKSIMEELLVEEGPDRETTQRPWALKSISPPKWNLCLEDFRQAVMTFPEELQREDALIQLNKAAMELCQEQKPLQSDLLYQMCLQLWRDVIDSLVSQSLWLRNLLGLPEKETVYLDLPDEQGQKSPPVTESKVTSGKAGKEDRRGGAQEKKQLGTKDKDDKRGSKTPGKEDRPNSKKLKPKDDKKVVKSASRDRLLSEDPPPDSTAPSQEPIDPLVMEKYTQRLHAEVYALLDNLVTDVMVLADELSSTKNVEESLRFCS
The following text describes a protein:
Function:
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (By similarity). Regulates the Rac-dependent signaling pathways controlling cytokinesis, actin reorganization and the contractile vacuole. Required for efficient accumulation of cap at the cell cortex.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDNHEEESNVPAYVPGKHVSVDQLKQQDAEDEALKRYKESLLGTGVHAPKDDPRKLVIKEMKIQIEGRPDTIYPLDTKELIKEMKTKPFVLKESCHYKITLTFNIQHDIVSGLKQTNTVYRKGIKVSTEKHMLGSFAPQALAHSVTNPRHGWEEAPSGMLARGSYTAKVVFTDDDNEEHLSVEYAFSIKSDWKSDD
The following text describes a protein:
Function:
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis. Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MAKFGVHRILLLAISLTKCLESTKLLADLKKCGDLECETLINRVSAMRDYRGPDCRYLNFTKGEEISVYVKLAGEREDLWAGSKGKEFGYFPRDAVQIEEVFISEEIQMSTKESDFVCLLGVSYTFDNEDSELNGDYGENIYPYEEDKDEKSSIYESDFQIEPGFYATYESTLFEDQVPALEAPEDIGSTSESKDWEEVVVESTEQDRIPEVHVPPSSAVSGVKEWFGLGGEQAEEKAFESAIEPVQESSFRSRKIAVEDENDLEELNNGEPQTEHQQESESEIDSVPKTQSELASESEHIPKPQSTGWFDGGFTSYLGFGDEDTGLELIAEESNPLPQDFPNSISSDKEATVPCTGILTEKKDTITNDSLSLKPSWFDFGFAILGFAYAKEDKIMLDDRKNEEDGGADEHEHPLTSELDPEKEQEIEMIKIIETEDQIDKKPVSEKTDESDTIPYLKKFLYNFDNPWNFQNTPKETELPFPKQILDQNNVIENEETEEFSIDNYPTDNTKVMIFKSSYSLSDMVSNIELPTRIHEEVYFEPSSSKDSDENSKPSVDTEGPALVEIDRSVENTLLNSQMVSTDNSLSSQNYISQKEDASEFQILKYLFQIDVYDFMNSAFSPLVILTERVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMVDISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESGRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDTRGPFLRRGPPFPPPPPGAMFGASRDYFPPRDFPGPPHAQFAMRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET
The following text describes a protein:
Function:
Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.
Subcellular Localization:
Cytoplasm. Membrane.
Sequence:
MSSSYRNRIQEFKLALSEQQVDLKALRELCFSGIPCEGGIRSLCWKILLNYLPPDQALWETFLEKQRDVYAQFLREMIIQPGIAKANLGVSREDVTLEDHPLNPNPDSRWNTYFKDNEVLLQIDKDVRRLYPDMAFFQRPTDFPCQLILDPQNEYETLRRRVEQTTLKAQTVNRNRSGVTNVSSPGKALHLYPSNEYAVLPNGCEAHWEVVERILFIYAKLNPGIAYVQGMNEIVGPVYYTFATDPNSQWKEHAEADTFFCFTNLMSENRDNFIKSLDDSQCGITFKMESVFSRLKQKDTELYIRLQEQNIKPQYFTFRWLTLLLSQEFLLPDVIRIWDSLFSHQDRFEFLIPVCCAMLILIRDQLLAGDFTTNMRLLQDYPISDVHSRSPERSSMNRSQIRGWSDDGLLYLYQ
The following text describes a protein:
Function:
Plays a role in the regulation of microglia polarization.
Subcellular Localization:
Secreted.
Sequence:
MERPTSNWSAGSWVLALCLAWLWTCPASASLQPPTSAVLVKQGTCEVIAAHRCCNRNRIEERSQTVKCSCLSGQVAGTTRAKPSCVDASIVLQKWWCQMEPCLLGEECKVLPDLSGWSCSSGHKVKTTKVTR
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Sequence:
QITELSNGVRVATHNSLGHFVSAGIYVDAGSKYESSENAGVSHMLDRMAFKSTEKYTTPQLIKELESLGGNVIAHSSREGIMYQASVFRHDLAKMIGIYGQMVQRPLFSDTELEETKETTRYELREISHKMDMIMSEVVHSIAFQENSLVNQTGPVVADATNILPIASNTLGNPLIVDEQSLEALSSKTLKDFHQTWYTPDRIVVAGVGMDHGRLVDLAEQAFGNMKIATPEIAAAQKKHTLSPRYTGGVRVWDTRILPPSPNPDDIPFTHVHLAFESMSMTDPDIYALATLTSLMGGGGSFSAGGPGKGMYTRLYTQVLNRCGWVDSCNMMNYTYADTGLLSIQAAVIPDRETHRIIVPVLAEQLVNMTRTIHNSELSRAKNQLKSNLLMSLESKIVELEDVGRQALSHNRRLDVLEMCKRIDMLTQQDLNRAARRVIFGE
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MPAAELRSQLNTRVSYMYAMGILDEYYQELQPPQDEGFVPEVINMFLHQADMMLNDITSLLNLPVVDFEMVGELVHQLKEYSGSFLIVLFLACISVGARKVNLACVHFQQFYEGKSKERCLMALNVLRNEFYDVRDRLQTIMQVASYVPVLAFDFQLLKSIKNM
The following text describes a protein:
Function:
Sphingomyelin synthases (SM synthase or SMS) synthesize the sphingolipid sphingomyelin (SM) through transfer of the phosphatidyl head group of 1,2-diacyl-sn-glycero-3-phosphocholine (phosphatidylcholine, PC) on to the primary hydroxyl of ceramide (N-acylsphingoid base), yielding 1,2-diacyl-sn-glycerol (diacylglycerol, DAG) as a side product. Functions as a bidirectional lipid cholinephosphotransferases capable of converting PC and ceramide to SM and DAG and vice versa depending on the respective levels of ceramide and DAG as phosphocholine acceptors, respectively.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTNSSEFTDVLQSRDPCVSNGIVINIDPIDPEPTPIRKEFTCEDTFHHEHHGNSEGFKTLTAFLCLMLSAFLNFFLLTVIHDVVPRQPLPDLTFMIIPQQRWAWSVGDVLSTVSSVVAFTIIFLHHQRWIVLRRTFLLGAIMYGLRAVILGVTFLPPSFHNRDEICQPQVNRTAMYGMEIATRFLTYVITLGLTSGQDKILCGDLMFSGHTVVLTIMYFVQLQYTPRGLVILRYIAAPITFLGIAALVVSGGHYTMDVLIAYWLTSHVFWSYHQIFEMRKDDRPQAPLSRLWWFWLCYWFESDVADGKLVNKWNWPLEGPQRMHTIMNRINYKLQ
The following text describes a protein:
Function:
Acyltransferase that catalyzes the N-acylation of phosphatidylethanolamine to form N-acylphosphatidylethanolamine (N-acyl-PE) (e.g. NAPEs containing C16:0, C16:1, C18:0, and C18:1). Also mediates the formation of acylphosphatidylglycerol (acyl-PG) from lysoglycerophospholipid by O-acylation. Uses acyl-CoA as acyl donors. Acylates 1-acyllysophosphatidylethanolamine (1-acyllyso-PE) and 1-acyllysophosphatidylglycerol (1-acyllyso-PG) at the sn-2-position.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
Sequence:
MGKIMEWAARSDHLGGIPRNTVIMAVSAFAKAVANLCNKSSVHNADTLMNLVQSRPPGVPLITVSNHMSTLDDPVMWGAFKGLLSLDPELARWVLAAEDICFRNPIFSYIFRTGKCIPITRGGGIYQENMNEALQRLKDGSWLHTFPEGKVFQDDVPIRRLKWGTASLIARSPVTPIVLPIIHRGFEEMMPENYNNGRRPLVPLPNKHLKVVVGEPIEFDVPMMVETAVLDSRHVTPPLQEVKWPVLTSAGQVLDETAQRHLYIALSEKIQSSLETLRLLAKRL
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGVEPNTAVPKLNAILTLNLNIDVLDRKHLIKEIFSEFEANQILNIPLSWRLPSDKRVWHWERNGNFSVRSAHHLIKDVDARNTLEASSTNGQEIWKAVWRIKTEKERIELLDTICPLCFEEEENRDHLFEVQIHATNLVQLQIGYPCPCTLIAEGKDFGWLSKKDHLASQYFGMALENLASRNQMVFQNKHFDPIQIANAAADFTVEFNDANMTVVTSLNVDVGCFNDGLMGRGMVVRDNGGNVKFAATKLDNIRVSLTMAEIIALRWGFNGSYLQIRMAIS
The following text describes a protein:
Function:
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MPSAKQLADIGYKTFSASMMLLTVYGGYLCSVRAYRYLQLRSARRQAAEEQKTSGVL
The following text describes a protein:
Function:
Involved in auxin transport. Regulator of the auxin signaling pathway.
Subcellular Localization:
Cell membrane.
Sequence:
MAFPQRKRTPSFSSSVLDSVYRSIDESDGLQSDLKGSINENVSSSSSSPSPNKKDDKLTTLRRAIMDEEHWLYARSSTTTTNSSDSSSFSSSEAESYRTKRRLRKLAEQGKRSGDERQRTKRTVMDNDSRLFSKSDDDKKPKAVKIIEELKRSKQPVSPGARLTSFLNSIFQSNAKKVKLCSVGKTTDVKSSSSKSCFSRTRNKTDNNNNNCKKLERSIRFYPVRVTIDGDCRDYAQKHITRVRKPIPEFTAKKSVKEEIKTNDHHTEFTCITRNIGLKDFVRSNKYEGKEEEEDAWSHSSSDLFELDSYRIGMGRYLKELPVYETTDFKTNQAIARSLLL
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane.
Sequence:
MSSKVAINSDIGQALWAVEQLQMEAGIDQVKVRVGASAGGGKRWEHMGQGTGACLGLVWLNQLVCRCPKMAADLLKFCTEQAKNDPFLVGIPAATNSFKEKKPYAIL
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSKMAGDYCLQEKIPSSLATFYHFLPRANFYFLNTSSTFAPTEDEYQQSLVLYGSAIIVIGSVVSFLLFIHFLVFCAATCCRRPVIRKRPKRLAILAILFCLSTLVCSACLIAAYVFNDKVEQGVNSVTIAIGNVNSTLVDSQMQVASIQNIMVDIRQTVESIKMLPNIPKEGRLALANIETFTITIIDTVGKIKPTTLPDINIYITNAECYRWWTSFGIVSLSALNCLLALYSLLRKCKTGFSIFTMLGTLAYFLNWALIGLQLVASIAMSDLCYDPRRTIDFYLSNKVLPIRNIANYYIDCKKSSDHPYKKFADTAMLELASAEQVVEWLILQVWLPTSSAQQLTTQINSTKTSLDKIETDLKCSAVKQQYDDARCAVCYPVVEGLSQLLLMAMIVSLFLGIVLSLITPIYNKIPHRKPRGQNVFEMCAGRVTSPETPYQSVSVDENSPLVPTAPPPEYQSCPNRDFQFHSCQEDMGPQIPRIPPPRGTHSQPTKEITNVAL
The following text describes a protein:
Function:
Possesses thioredoxin activity (By similarity). Acts as a ligand for Drpr and is required for the phagocytosis of apoptotic cells. Binds to the extracellular region of Drpr and augments Drpr tyrosine phosphorylation.
Subcellular Localization:
Endoplasmic reticulum. Cell surface. Note=Relocates from the endoplasmic reticulum to the cell surface during apoptosis.
Sequence:
MLTRSILSVAVCGLLLSPLLPITRASQEEDTGKQDKQFTVELDPETFDTAIAGGNVFVKFFAPWCGHCKRIQPLWEQLAEIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEEESVKFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIGKVVDLTEDTFAKHVSTGNHFVKFFAPWCSHCQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSICQDFEVKGYPTLLWIEDGKKIEKYSGARDLSTLKTYVEKMVGVPLEKTAGEAGDEKVVIEEVAGEEDAAKKLTPQQLTGEDEFDQAIAEGVAFIKFYAPWCGHCQKLQPTWEQLATETHQAQSSVKIAKVDCTAPENKQVCIDQQVEGYPTLFLYKNGQRQNEYEGSRSLPELQAYLKKFLGHDEL
The following text describes a protein:
Function:
Major role in the synthesis of nucleoside triphosphates other than ATP.
Subcellular Localization:
Cell projection, cilium. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm. Nucleus.
Sequence:
MELTHLGDQIRVERTLAIIKPDIYEKAEKIEGFILQSGLTILQRRLQLSQEQCSDFYSDCSGKPFFPSLMAYMSSGPIVAMVLACEDAVTRWKSIIGPASITNAKESQPECLRAKYGTSDLKNALHGSESFQEAVREIKFMFPNSFIEPSPSKHETKEYLSRCLKPVLLRGLTELCKEKPLNPVIWLADWLLQNNPNQPQTYF
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MALSRPNWRVEAAQANERQTCQTFLAPASPIFALAKLEDPEAAQANGVRHSRQKLVNWSPATYPRVSTVPVEFRDLRWAIVASKHRSLRQAAEALRIKQPTLSRGLRNLEYRLGVTLFKRTNGGTRPTVEGQEFLEAARRFVDETEAITVRGKNRSRGESGRLTIGIHTSLSAGNLRATLIEHRHRFPDVDRQLVDGASDHLISDLASSAIDVAFVAGLSPRWSDRSLLLWSERVVAALPANHPLTGRDVIHWGELRHESLLMSQRGPGPEFLKLLDSKLGSSDPCPLVRHDVVLDRLLSLVGVDWGILLVLESATGAVYPGVTFREVHDAEGPTRLSLRAYWRQDNANPSLRPLLDLLRERYPDISAAPDAS
The following text describes a protein:
Function:
Functions together with the other V-type ATPase assembly factors in the endoplasmic reticulum to efficiently assemble the V-type ATPase membrane sector V(0).
Miscellaneous:
MISCELLANEOUS: Present with 5750 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MANFFVRLWESVFEPGTSPQLIIATHVSFVALLLTLIWLIYATNGNIHFYALFCISLLLWITVIWFINELSHVKLKDNDELDKDANKKDDSAIKEDSEDKQESGKSTSTARRTQAQSRSRKA
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDFAAYISGLPGPKRGALYRSPWTCLAVFRNLPPLAQVYVMRLLFVPSPFPADFVDSWAAKGAASGHKAALSALRGLDVLTEVAAPGGPGGGGGPDAGAAAALAARAAARQQRGGVGAVALWCLHPDFRAQLQTVVCSGSQLMRGDVPAAAASCCPSLEELGEWAVGQWEALQLYLLGSSRSPPQLPQLLRARNYKELDIRSLLVEAGLLAFLSDIAAAAVANAAGGSSGGGRPATRGGAGSSSLAVTQRSFHWLLQPGDRQLWAVLREYISGAEAASGDELAHTLSFLLQLGFRRVGQPCAWAELRPPEQRMAAHLAQLGVLAVFQTDDGEVFYTPTRLAASLCGGSGGAGGGAGGAAGGKGSAGAAGSGGALAARGGGAGGAAAAAAMDGGGAGSDAFVIVESNYRVYVYTRSPVTIAVLELFVKREALLPNLFVGAIRRDSILAALARGITADELVAYLSARPHPSIAARCPVVPEVVSDQIRLWEASMNRLQAHPAVLYENMESRQLYERAVAAARAAGTLQWEDGARMRFVALESGHEAMKLLIVKAKQDLKL
The following text describes a protein:
Function:
Transcriptional activator that binds DNA on GAGA-like motif and 5'-(C/G)ACGTG(G/T)C(A/G)-3' consensus motif in the promoters of target genes. Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus (By similarity). Required during flower development and for cell fate determination. Acts both as an antagonist and as a promoter of polycomb LHP1 gene regulation activity, depending of target genes, to regulate the transcription of stress-responsive and flowering genes. May regulate histone H3 trimethylation on lysine 27 (H3K27me3). Recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and acetylated at 'Lys-9' (H3K9ac), leading to epigenetic activation. When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes. May function as a suppressor of cell-autonomous immune responses involving glucosinolates, salicylic acid (SA) and jasmonic acid (JA) pathways toward pathogenic bacteria and fungi.
Subcellular Localization:
Nucleus. Cytoplasm. Microsome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Sequence:
MSDARDNDDRVDFEEGSYSEMEDEVEEEQVEEYEEEEEEDDDDDDVGNQNAEEREVEDYGDTKGGDMEDVQEEIAEDDDNHIDIETADDDEKPPSPIDDEDREKYSHLLSLPPHGSEVFIGGLPRDVGEEDLRDLCEEIGEIFEVRLMKDRDSGDSKGYAFVAFKTKDVAQKAIEELHSKEFKGKTIRCSLSETKNRLFIGNIPKNWTEDEFRKVIEDVGPGVENIELIKDPTNTTRNRGFAFVLYYNNACADYSRQKMIDSNFKLEGNAPTVTWADPKSSPEHSAAAAQVKALYVKNIPENTSTEQLKELFQRHGEVTKIVTPPGKGGKRDFGFVHYAERSSALKAVKDTERYEVNGQPLEVVLAKPQAERKHDPSSYSYGAAPTPAPFVHPTFGGFAAAPYGAMGAGLGIAGSFSQPMIYGRGAMPTGMQMVPMLLPDGRVGYVLQQPGMPMAAAPPQRPRRNDRNNGSSGGSGRDNSHEHDGNRGGRRYRPY
The following text describes a protein:
Function:
Probably involved in membrane trafficking.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.
Sequence:
MARRYDSNPFEEEEEEVNPFADTGARGKATGLNYGGGPFYMNPATVPPASNSRLSPLPPEPADFYNDRSATIDIPLDTAKDLRKKEKELQAKEAELNKKEKELKRREEAAARAGIVIEEKNWPPFFPIIHHDIANEIPIHVQRLQYFAFASLLGLFACLFWNIIAVTAAWIKGEGVKIWLLAIIYFIAGVPGAYVLWYRPLYRAMRTESALKFGWFFLFYVLHIGFVIYSAVAPPIFFKGKSLTGILPAVDIIGDHLLVGIFYFIGFGMFCLESLLSVWVIQQVYMYFRGSGKAAELKREAARGAMRAAI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAAVPDLQPLPALEQDLEQNEILIVKVEEDFCLEEEPSVESEDPSPETFRQLFRLFCYQEVAGPREALSRLWELCCRWLRPELRTKEQILELLVLEQFLTVLPGEIQARVREQQPESGEEAVVLVEGLQREPRKHRQRGSELLSDDEVPLRMGGQSLKRQAEAQPEDLSLEEEARCSSQQPPAQLSHRPQRDPLLWPERGPPAPRHQEIASASPFHSAWSQAPVNLEDVAVYLSGEEPGCLDPAQRDVPLENEGLGIQLEDGGDGREDAPVRMEWYRVLSARCQGPGHPLPGQRPAPVRGLVRPELPRGGPQPGRGASHGTDKPYTCPECGKGFSKTSHLTKHQRTHTGERPYKCLVCGKGFSDRSNFSTHQRVHTGEKPYPCPECGKRFSQSSSLVIHRRTHSGERPYACTQCGKRFNNSSHFSAHRRTHTGEKPYTCPACGRGFRRGTDLHKHQRTHTGAGSLLTLQPVAPGGPGAKA
The following text describes a protein:
Function:
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Sequence:
MSRSLGIPVKLLHEAAGHVVTVELKSGELYRGNMIECEDNWNCQLESITFTGKDGKVSQLEHVFIRGSKVRFMVIPDMLKNAPMFKRLDARIKGKGSALGVGRGRAVAMRARAQAAGRGAPPGRGVVPPVRR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MANEEDDPVIQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVELEMAIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTARYAAALYRQGELHLTPLHGILQLRPSFSYLDKADAKHREREAANEAGDSSQDEAEEDVKQITVRFSRPESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGMRDSRSEHERQYLLCQGSSGVENTELVKSPSEYLMMLMPPSPEEEKDKPVAPSNVLSMAQLRTLPLADQIKVLMKNVKVMPFANLMSLLGPSVDSVAVLRGIQKVAMLVQGNWVVKSDILYPKDSSSPHSGMPAEVLCRGRDFVMWKFTQSRWVVRKEVAAVTKLCAEDVKDFLEHMAVVRINKGWEFLLPYDLEFIKKHPDVVQRQHMLWSGIQAKLEKVYNLVKETMPKKPDGQSAPVGLVSGEQRVQTAKTKAQQNHAFLERELQRRKEQMRAATVLPSVQIKEEPLSEEEADGAELEAEEEEPMDTAPSTCLSTKLANGLPAGRAVGGDSLNGHPVPGCASNPVACELKAFVEATFQRQFVLTLSELKRLFNLHLAGLPPGHILFSGVSDRMLQDTVLAAGCKQILVPFPPQTAASPDEQKVFALWESGDMSDQHRQVLLEIFSKNYRVRRNLIQSRLTQECGEELSKQEVDKVLKDCCVSCGGMWYLKGTVQS
The following text describes a protein:
Function:
Involved in the anaerobic metabolism of phenylalanine and phenylacetate. Catalyzes the oxidative decarboxylation of phenylglyoxylate to benzoyl-CoA and CO(2). It can also react slowly with 2-oxo-3-methylbutanoate and use different electron acceptors such as benzyl viologen, methyl viologen, FAD or FMN, but NAD seems to be the physiological electron acceptor. Also catalyzes an isotope exchange between CO(2) and the carboxyl group which proves partial or complete reversibility of the oxidative decarboxylation reaction.
Sequence:
MSRHQSYPLFNLEQAGVPDDLCPVATVVSPMLPGDWRSMRPVVDRDKCVKCAVCWLYCPVQCVEEHAAWFDFNLKTCKGCGICANECPQRRSR
The following text describes a protein:
Function:
May be involved in cell cycle regulation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Also localizes to the barrier septum.
Sequence:
MSNSILKVPDQNPQEIVALFSQQEAYAKLGKYKDEIWDVYQKVFIAALTTGETVLAKKCWNRLNDRFHKSPRVEGLYGMFLEATASEKDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPFEPRLFARLGDLYFVLAQSNATNYWFSLKHYCRSVEICEEYFHGWFGISKCCQQLLELSRTELKRLLSKVNEKISDTFPDTESVRQLYQLSLKKSDLFAQKQPKLKALLEQC
The following text describes a protein:
Function:
Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
Sequence:
MAPTPERYAKIRRVLSKRQPTLTVLMDEVNKPHNLSAIIRTCDAVGVPEAHAVPPKHGTLASFEGHTYEATSGSAHKWVKVHPHADAVSAVRELQAQGFQVLATHLSQRSVDYREPDYTKPTCVLLGAEKWGVSDEAAEAADANIVIPMFGMVQSLNVSVAAATILFEAQRQRLAAGMYEEPQLSPEELHRLSFEWGYPDLAPGYRERGEAYPALGEEGELLREPVSRPE