lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MLHFSRWKTVFIWLLVLASVFIASPNLFSEKQLESMPAWYKDNKVTLGLDLQGGSHIMLKIERSDIVKERLETIVGDVRTQLRDANIRYSGLTGNGQQIQVRISDPAQMEAAKTALRDLTQPVSAGTLVGGSITEVTMNDGGDSLLRLNLTDEGIDYRLSSAVSQSIEVVRRRVDEVGTTEPLIQRQGSDRIIVQVPGLQDPQRLKSLLNQTAKLSFRMVDTTMPAQDAMNGRPPATSEVLYSQDDPPVPYLVERRALVSGDNLVDAQASFNQQTNEPVVTFRFDSRGAQRFAQATQQNVGKPFAIVLDNQVISAPVIREPIIGGSGQISGSFSVQGANDLAVLLRAGALPATLTVVEERTVGPSLGNDSITAGLTASAIGAVGVLIFMFVFYGFFGLLANIALIVNVVMLIAVLSVIGSTLTLPGIAGIVLTIGMAVDSNVLIYERIREEVKSGKPLIQALDNGFTRAFATIIDANLTTLIVASVLFYMGTGPVKGFAVTLAVGIITTVFTAYTLTAWMFGYWVRRSRPKHLPKGVRTAMFDGRDIPFMRYRRVVFMITGVIMLACVGGFVAKGLNLGIDFQGGSVIEVRAKQGEADLADIRERLNQLNLGEIQAQNFGSPQDVLIRIQAQDGGENAEQSAITLVRGELEDKYDFRRVEVVGPAVSGDLTVTSTIGVLLAMAAIMVYIWVRFEWQFALGAVISMVHDVVFTIGLFVFLGIEFNLTSIAAILTIIGYSLNDTVVIYDRVRENLRRYKKMPLSMIIDVSLNQTLSRTILTGLTVLLALLALYLFGGEVIRSFTFAMLFGVGIGVFSSVYIAAPVLIAFKLRPDSKDAEDEKDDKKENNTGAIGGKPAV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDNIVDSLNKAYEKFVLASAGVLESKESAGGQKALLTDTALENFKEKWELFRVACDQAEEFVESVKQRIGSECLVDEATGLTTTAAGGQAPAAVTGAATSLPPISAVRLEQMSRAVRWLVLELQRGSGVAPGSVHSSSTGFDSRFSEDSTQ
The following text describes a protein:
Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVLHFILLLLLLKDNGNGNVGFLVSAQTNERRVVSYMAGDIIIGALFSVHHQPTVDKVHERKCGEIREQYGIQRVEAMLHALDRINADPALLPNISLGCEIRDSCWHSAVALEQSIEFIRDSLVSSEEEEGLVRCVDGSSAPSRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLYKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGERGMEAFKDMSAKDGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVVCFCEGMTVRGLLMAMKRQNLIGEFLLLGSDGWADRYDVTDGYQREAAGGITIKLQSPDVKWFDDYYLQLRPENNLRNPWFLEFWQHRFQCKLKGYSQESQKYNRTCNSRMTLRSQYVQDSKMGFVINAIYAMAYGLHNMQTELCPGYAGLCDAMKPIDGQKLLDSIMKANFTGVSGDMITFDENGDSPGRYEIMNFKKMAKDYYDYINVGSWDNGELKMDDDEIWSNKNLVIRSVCSEPCAKGQIKVIRKGEVSCCWTCTPCKENEIVFDEYTCKACDLGSWPTDDLTGCVLIPVEYLRWSDPEPIAAVVFSCLGLLATMFVMAIFVLYRDTPVVKSSSRELCYIILAGICLGYLCTFSLIAKPQQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFLLICIQLGIIVALFIMEPPDVIFDYPSIREVYLICNTNNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLSISFTPGPTHSYCQQPIGISNGKSVTWAQNEKSSKSQHLWQRLSVHVKKKDSTNQTAVIKPFSKSSSENRFISTSFPDTSAKMLYDVSEAEEHYPVQYRPQTPSPISTVSQRAISTIHTEDDIPSFHSDMAQRSGSSQGSLMDQISSVVTRFTANISELNSMMLSANSQGTMVPTPLCSSYLIPREIQLPTTMTTFAEIQPAPNIDFNGGTQSARKSSDSVKDGAPEAAVVKQDVEELVALTPPSPFRDSIDSESTSPSSPVSESALCIPSSPKYDNMIMRDYSQSSSSL
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MTDSAINKKSKRSIWIPLLVLITLAACATAGYSYWRMQQQPTTNAKAEPAPPPAPVFFALDTFTVNLGDADRVLYIGVTLRLKDEATRARLNEYLPEVRSRLLLLFSRQNAAELSTEAGKQKLIAAIKETLAAPLVAGQPKQVVTDVLYTAFILR
The following text describes a protein:
Function:
Has antimicrobial activity against Gram-positive bacteria S.aureus ATCC 2592 (MIC=5.0 uM), S.aureus ATCC 43300 (MIC=10.0 uM) and B.subtilis (MIC=20.0 uM), against Gram-negative bacteria E.coli ML-35P (MIC=50.0 uM), P.aeruginosa PA01 (MIC=10.0 uM) and P.aeruginosa ATCC 27853 (MIC=5.0 uM) and against fungus C.albicans ATCC 2002 (MIC=10.0 uM).
Subcellular Localization:
Secreted.
Sequence:
MFTMKKSLLFLFFLGTINLSLCEEERNAEEEKRDGDDEMDVEVQKRFIGPVLKMATSILPTAICKGFKKC
The following text describes a protein:
Function:
Hydrolyzes homoallylic isopentenyl diphosphate (IPP), its allylic isomer dimethylallyl diphosphate (DMAPP) and short-chain prenyl diphosphates geranyl diphosphate (GPP) and farnesyl diphosphate (FPP) to their corresponding monophosphate forms with high activity. The preferred substrate is IPP. ADP, NADPH, Ap5A and thiamine diphosphate (TPP) are weakly hydrolyzed. No hydrolysis with ATP, dNTPs, 8-OH-dGTP, NAD+, FAD or acetyl-CoA. The likely physiological role of this enzyme is to provide a substrate dimethylallyl phosphate (DMAP) for prenylated flavin mononucleotide (prenyl-FMN) synthase MM_1871 involved in the biosynthesis of prenyl-FMN, a coenzyme required in the archaea-specific mevalonate pathway.
Sequence:
MISEVDMDDNFLGLRARDEFYSGKHIHRASQLILLDPENRILLQKRSPGKFWFPNRYTYSVSGTVADESYEACIAREMLEEIGISVPFRRLFKIPCIRENKGAYHTIFSGRCSEEAASLIRHDLEEATSIEWVELEELHRAVKAEPGNYTPALREGIIKIFKEGCEKYLF
The following text describes a protein:
Function:
Mediates the nuclear export of proteins (cargos). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. Xpo4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MEIEFIQNLEKFCIGLQSNKSNERETSEQSILTLMKTPQPYKLCFNLLSKSNLTIAHFYGLLMIRDSAIREWAALDSQTKIMIIETLFQYIENMNSMNFLNYATKGQSFNTLGVIIKRSWLDNEKYEIGKGQMELNQIVMDRVYQYIDSGSPDRIEISIKIIGSLIIEFSSSSKAAHIQLSWEFHQKCLITFQNLHLQPIFRKVLELLQQFKDHIQQVPSRLTDQSFLQILYTSVKVFTDILDWRFLESGSSVLAYITSFSGGRTNLKPTIEWISLFTPSQSGGGISPIVSLVFGLYQLVEKVEKIPNLLRHAMSQLCGLQGPIIKDQKIKNQYLSEVLTFTNKLIEKSITTRNWNEMEDISNIIYKFCNTYKFSGIACLPNQIVIPFLQYTTQFVLSSLNLMKIWAKHGEEELEEEFENDCFDILLRSFVSLISDAEMLINRKRVDQLENFKEQYQVLKQCTSQIYQNYIQSRLELSEIEINKSNEELEPTCKSRGGIGGAEDEIDEDKKKYDEQLRSVAYIGRLNPGQSLELLKNEINRVINSLKERVSDPILFESLHWLLIFAGHLIFDAENKTPSAIPNAIEDYTFEQCKLTPASQVDGVIDLCNAVFRFHMEYENPLLNNGKMDTISPLVSQTSLWFTSGWSLVYLLPSSVFNVQISPKIIEAYGTEQPLLSITDYFINKILLNLKCWSGDLDVLKATSNLLNSFTLNKELCKYLIRSPNWSRLFFLEGISLLPPSVYGQLFKAFSRVVFSFPLSTRREYFIQLVKTLVEQMDGVLGRADFTKISQEAKIKENIYILLEKLNGIVSVSESEYVDDEDDCLFLTVDLFTKYATSLIAMIPLYDHCNDIVLLILRLFSNFTKHQLEYLNQDRARSIFPLIIQLFNSVATTSSHKKTLDSKEYYHRVRMMVKILTNIITFGDQRNNCPTIISETIFHAINIITPCLSNNDLLLYPKLARNYFMITSFLFGADNIQVKNIPVINTIYSLIEAGILHHDLEIVKSCFECIGCLTKSLENSKEKSGGLVDPHYQSVLIQFIGSVINFLLLQDFNVDELLSVASETLFSLMYSSPDGYRSKVIELITRQDPSIQSRVVQQFETLTIIGTDRKSKDLFMKNLQNFLVNVKSLINKK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MNFCPICSNFLSLENESSTGYRLKCPGCVYYHPLKEMRLTKTFQSKEPAPITYPQQNKQITDEQCDKCGCLKAFFWEFQTRGADEQSTISFECIKCGHKWKNDR
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAVIVAVVVTVVVNKDDHQSTTSATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAMANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEVTITSVLLD
The following text describes a protein:
Function:
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MTHSKRWLEEHEKDPYVKRAKKEGYPSRAAYKLLEIHQKYKLFKPSMNVIDLGAAPGGWSQVAKDLVGPKGVVIAIDLLPMQSMLDVIFIQGDFNEPEIFNQLEAIVAKKTLTGQVDLVISDMAPNISGIKNVDQSRSLHLVELAWDCAQKLLARGGTFLVKVFQGPGVDRFLINLRPYFNQVKFLKPSASRSRSSEIYILAGEFLGYNQRV
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEVARTVRIPHAFDGLTLSRQATMRRTLFLIPHEFAGWPIFGIGWALLFLLIAVLAYVGWESRRGGLGASTAIRQIAGFAVMAAVILVVVVPRTELVNTLGDPVGVAVRGYGMFLMLAAIASVGLAAWRAERAGLGADSILQLAPWTFIGGLLGARVFYVTQYYEDFLRPTWGETLMAMAALNQGGLVVYGGFIGGFIASLIALKRHQTPIWRIGDVIIPCVFVGLLFGRLGCLMNGCCYGGACEAGPLAVQFPAGSQVHAEQLLSGELLGIEGHPVVSDEEPPAGQSQMVVDSVRPDSLANQAGVKKGETLTIALDPSYRDQVPLDRPAEEALPGVVVLRDDEVVARFSPRDLPSIADPVWGTQIISSVFAAIMFVVLLIVERILHRPSKQTDDAVTERAITGGRRPGVLMLVGFIAYGVLRIVLEWIRVDEKGQFGTSLSISQWVSLVVIAASLVTLFIRWRGVDSTSEQTPGGGNTNVVGGSDAAAAGL
The following text describes a protein:
Function:
Has both endo- and exonuclease activities. Incises double-stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity. May have a role in apoptosis (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASIRQAFVKSLRFYDIGYNATDPVFRGIYHEKLKHPDDFDSIISRAKAVGVEKMMITGDNVENSEEALNLATNYECFTSTVGVHPCQAQCFLRHSEGPEDYLVKLEALANKGKASGKVVAFGEFGLDYDRLHYAPADVQKMYFEEQLKVAVRVQLPLFLHSRNAENDFFAILEKYLPELPKKGVVHSFTGSIDEMRRCIEHGLYVGVNGCSLKTEENLEVVRAIPLEKMLLETDAPWCEVRPSHAGHQFLKTKLPFDSCKKERFKEGCMIRGRNEPCNTYIVAEIVAALKDISLEELSEQIWENSINLLSK
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MKHEKPYFKTIMGSYHQCFLFSATVLLHILLSTVFCFAQHDLQPPIASHEGAAFEEKARLGSTPPSCHNKCNGCHPCMAVQVPTLPNQNRPAQPVSTKTSIIDPFFDPYPAGNNRYSNYKPLGWKCRCGDHFYNPLS
The following text describes a protein:
Function:
Adapter required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (By similarity). May activate the same pathways following detection of extracellular dsRNA by TLR3 (By similarity). May protect cells from apoptosis (By similarity). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion. Peroxisome.
Domain:
Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with RIGI and IFIH1/MDA5 (By similarity); The transmembrane domain and residues 285-420 are essential for its interaction with DHX58/LGP2; The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of MAVS recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines; Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with RIGI and IFIH1/MDA5; The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2.
Sequence:
MTFAEDKTYKYIRDNHSKFCCVDVLEILPYLSCLTASDQDRLRASYRQIGNRDTLWGLFNNLQRRPGWVEVFIRALQICELPGLADQVTRVYQSYLPPGTSLRSLEPLQLPDFPAAVSGPSAFAPGHNIPDHGLRETPSCPKPVQDTQPPESPVENSEQLLQTNSGAVARMSGGSLIPSPNQQALSPQPSREHQEQEPELGGAHAANVASVPIATYGPVSPTVSFQPLPRTALRTNLLSGVTVSALSADTSLSSSSTGSAFAKGAGDQAKAATCFSTTLTNSVTTSSVPSPRLVPVKTMSSKLPLSSKSTAAMTSTVLTNTAPSKLPSNSVYAGTVPSRVPASVAKAPANTIPPERNSKQAKETPEGPATKVTTGGNQTGPNSSIRSLHSGPEMSKPGVLVSQLDEPFSACSVDLAISPSSSLVSEPNHGPEENEYSSFRIQVDESPSADLLGSPEPLATQQPQEEEEHCASSMPWAKWLGATSALLAVFLAVMLYRSRRLAQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base. Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. Cannot catalyze the reverse reactions. Is required for optimal growth in glucose minimal medium, possibly because it contributes to nucleoside pool homeostasis by degrading excess nucleotides and feeding back the ribose moiety to catabolism.
Sequence:
MITHISPLGSMDMLSQLEVDMLKRTASSDLYQLFRNCSLAVLNSGSLTDNSKELLSRFENFDINVLRRERGVKLELINPPEEAFVDGRIIRALQANLFAVLRDILFVYGQIHNTVRFPNLNLDNSVHITNLVFSILRNARALHVGEAPNMVVCWGGHSINENEYLYARRVGNQLGLRELNICTGCGPGAMEAPMKGAAVGHAQQRYKDSRFIGMTEPSIIAAEPPNPLVNELIIMPDIEKRLEAFVRIAHGIIIFPGGVGTAEELLYLLGILMNPANKDQVLPLILTGPKESADYFRVLDEFVVHTLGENARRHYRIIIDDAAEVARQMKKSMPLVKENRRDTGDAYSFNWSMRIAPDLQMPFEPSHENMANLKLYPDQPVEVLAADLRRAFSGIVAGNVKEVGIRAIEEFGPYKINGDKEIMRRMDDLLQGFVAQHRMKLPGSAYIPCYEICT
The following text describes a protein:
Function:
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).
Sequence:
MGVSRSTLRTEEIEEIREVSIFSQREIKRLYKRFKRLDKEEKGSINVEDFNQIPELSMNPMLPRIISIFDVNRDGQVNFKQFVKSLSTFHPKADKADKIKILFKVYDINNDGFITRDEIETILTMMVGSNLTKEQISSIVEETLNEADVNGKGKLDYPDFYNSIGSSGCNAENMLSISFNPFE
The following text describes a protein:
Function:
ABC transporter that may affect phytic acid transport and compartmentalization. May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAATPAWDWEESLVFFLQPFFLHGVSAAAHLILALAVAGRLLFRRLSASRTKDGEVGGGDASRGVGRFRYWYGVSVCTTWAMGAFEVLLAVYSWYANGGAGWSRDAVVEQVDAAARAVSWLLLAAYLQFDFWWRRQRQERFPVALRLWLALFMLLSVVTVGVHAAMILDGSLVPGRSWALDAVSVTAAAVLLSVSAGFFGRKEGEGGGHASEAHEPLLNGAHEGSGDDDENSSSAADASLFTGAGFLSVLTFSWMTPLLGVGHRKTLVPEDVPGLEPGDSVAGVLPPFKANLEALTGDGGRSSRKAVTAFKLTKALLRTLRWHVAVTAFYTLVYCVAVYVGPYLIDSLVQYLYLNGDERYASKGQLLVLAFVVAKVLECLSQRHLFFRLQQAGIRARSALVAVLYQKSLALSSQSRRSHTSGEMINIVSVDADRVGIFSWYLHEVWQVPLQVVMAMFILYSTLGVASLAALGATVATGLATVPLGRMQERFQEKLMDSKDGRMKATSEILHSMRILKLQGWEMRFLSKIIELRKTEANWLKRYLYTSATMTFIFWGTPTFVAVVTFGACMLMGIPLETGKMLSALATFRVLEEPIYELPGTIAMVIKTKVSLDRIASFLCLDELPSDAVQRLPRGSSADFAVSVGNGCFSWEASPDAPTLKDLNFQARPGMRVAVCGTVGSGKSSLLSCILGEIPKLSGEVRTCGTTAYVSQSAWIQSGKIQENILFGMEMDRDKYDRVLESCALKKDLENLPFGDQTVIGERGINLSGGQKQRIQIARALYQDADVYLFDDPFSAVDAHTGSHIFKECLLADLASKTVVYVTHQIEFLPAADLILVMKDGRIAQAGRYDEILGSGEEFMELVGAHEESLTALDVVDAMNENEANVSSSPSSRIETPNLSRSLSLAEKKHGATNEAEGDDDDARSGQLVQEEEREKGRVGFWVYWEYLTQAYKGALVPLVLLAQTLFQIMQIASNYWMAWATPASKDAEPPVSAPTLLFVYVVLALGSSLCILVRSLLLATAAYKTATLLFNKMHLSIFRAPMSFFDSTPSGRILNRASTDQSEVDTNIADQMGTVAFSIIQLVGITAVMSQVAWQVFVVFVPVFAACVWYQRYYIDTARELQRLVGVCRAPIIQHFAESIAGSSTIRSFGKEDQFVSTNSRLTDAYSRPKFYNAGAREWLCFRLDVLSSLAFAFSLIFLINLPAGLIDPGIAGLAITYGLTLNTLQAQVVWSMCTLENKIISVERILQYMGVPAEPPLVMPENKLAQSWPSNGEIQLQNLHVNPSPPFFMYETNSVMQSNTRFVSVCLSVCLLQVKYAPQLPFVLKGLTVAFPGGVKTGIVGRTGSGKSTLIQSLFRIVDPAVGQIVIDGIDIRTVGLHDLRSRLSIIPQEPTMFEGTVRSNLDPLGEYSDDQIWEALDCCQLGDEVRKQELKLDSPVVENGENWSVGQRQLVCLGRVILKRSKVLVLDEATASVDTATDGLIQRTLRRQFKETTVITIAHRITSVLDSHMVLLLDNGVAVEHDRPDKLLEDKSSLFSKLVAEYTMRSVLT
The following text describes a protein:
Function:
NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (By similarity). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPTCWILNESVSFVVALLWLAINIYLFIDTFCWYAEEESFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTLYTGTTTQLLMTVSGITGLVISLALILIMTSSTEFIRQSSYELFWYTHHIFIFLFISLAIHGGGRIIRGQTPESLRLHNVTFCRDHFDEWQEAASCPVPQFSGKEPSAWKWTLGPVVLYACEIIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLEWHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFGAEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPGLSKVYFYWICRDAAAFEWFADLLLSLETQMSEQGKAHLLSYHIYLTGWDEYQAIHIALHWDESLDVITGLKQKTFYGRPNWNEEFKQIAYNHPSSSIGVFFCGPKAMSKTLQKMCRLYSSSDPRGVHFYYNKENF
The following text describes a protein:
Function:
Plays a structural role in chromatin. Chromatid cohesion molecule required for equal sister chromatid separation in anaphase. May form a stable link between chromatids in S phase that is split rather than removed in anaphase. Also required for spindle-kinetochore interaction in early mitosis and inhibit sister chromatid separation until the cleavage of Rad21 in anaphase.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromosomes in a punctate fashion throughout the cell cycle.
Sequence:
MLFEMTPETFKKVNSSNRIIKGLQYTPLASSIPLENGLQNVLYPSSKFQNEPLQLNSEESSIMQRYVDMLNPGATFVNDSETFNFYKNALSAMITEPAMPAMRVNASPVLDQKVCNSDSLSELNDFTKSLIQPSMLMCEPKEKPDASSINTNRSSSDNGFLTPSSSPRSPSCSRVFNAVQLCSPKKSKDDITTPKKRLMEDTYSPRESPSKIQRLQDVLLKQLQDTRLLISQVIEAENSEDFSSNSLFIKREDDDGKHISSHAIEKLYMALTKLSRLGACDKLLEEGSIILVKQILEKELKELPVACYSIINLHDSLTQFPNLDFILKTTALVLFIIFLVPSFKKLQNEESILHLLNILHSIFEYTVPEAIDNIVQSKTSDARTSEIQHLSVLLQKVANVLNILSKVAHEIPLSEAVVIRIVYLFPKVSTLDNSFKTKLPNCNSSSFDFLKAPLFQTLQYLFRLYPYQRDFIIEESLTNFSHLPTARSVSRTYRLSNGKSIQYYSTLFVRLIQSCSIQNLFDSEIVQSESKSTEALHSGNLTEHLKTVESILSKSRHEEYRIANHIVAYLLSRSLKQNKTESDNSFAILTKILLEDLLNMLSLPEWCGTETIIRQFAMNLVMTVTNDKQAVSSKNAALDLISLIVNKVLALFDLSLFEKHNIPAPTNFNDIISFIPSITRLNELSQVSFNHFYFLCKGDISLENILPYNYNKWFSFLLQLRKVCNDSEALKIIDNCIDKNMQKSQEGFQGPSPFKADENDEDIFIISLYHSSLFLNLKFFVSLIIGFLDSPQASLRTKCLRIINQMKTIPSILRTHPEVLAQIISKSNDQSAIVRDTVLDLLGTYIMAYRETIPQIYGCIISGISDPSTIVRKRAIKQLCEVYEATEDLNIRVDIASKLLTRSNDEEETISELSLEVLEKLWFSPASNELDCQKGYEQLTFLEKQKLRVQYFPILKLCAEPSTERHVLLVTSLKTMLTSKEEINLSTLHTQIRLLLSCLFNQLIEVVTEDQVDESTKGILYEIMSTLFVFSRAFPFLFDLSYLHLLKPYLRSASTIEEQRFLYYVVAIFRQVLPFQKEISESFLRSLESVLLQRLTKAGTATLMEIVPCLCSLFTRLNDYERLKKIVVSCLKSLEEARHSENNFQKMVRLIDLIGLFSRYGDLNRINDDWKHSLDFISPECDDAYVILLGYFQKLLKDAKGQLRIHIIDNMSRICLRETSLFISPLMLSTLDMIIAENNVNEVSVLFKSFLELLAADEDLIFEADQKLSLKGKQNVQSNKSVDRDMLKGTKDKQWIEGVSASLMQHFLPCILDSCFSKNLRYSMLGIEILKCIIHQGLVNPRMCFSTIIALESNAIKETREVAILLHTELHRRHESLIDGLYAQSADLIFSLQKTEEYQTFKLGEFSPFQSAYTIVSADKSSKSRKKLIMQILKPLKLDGIDLPSFTEEKVSFVSFCCVCLAGIPYVSIEEPLMIISTVDSVLATIGPTITGWMKKLDHERFKILAGINLCNLIYLKRYIKYAFSISDSSRPIREKKPLTLLNRGYVDLITSDAKPDIVSKLVIKLFEEENILSGEDQVEGEQLTVV
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MSDDPMADFLAREKAALGDDADFFANPTPSAASGIDAFPDLTSPAVEPESTPVKPPTPQYQGIDAFPDIDTPAVDGTQIKVTGPAGTGEDEDVMKFESAFPDLSGETGSQPASKPIFNALSPQPYGASPYPPTATTAVSRSPHPSILPAPTFNNILPTADEDTEPIKAWKARQAEEIQKRDEADKKRRDEMSDRAEKAIDQFYEEYNKMKEKNIRENKESEAEFLEKLQEGVAKGTAWERISDLISLENSQSKTIRPSVPGGSDLARMKEILLALRREGDKAPGAAGF
The following text describes a protein:
Function:
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Subcellular Localization:
Cytoplasm.
Sequence:
MAITDYCECRFTAGNGGNGIIAWKREAHYDKGGPGGGNGGNGGNVILQADHNCDSLFFLKNKKHLFAEDGQNGKPDLAHGKNGSDLLIKVPIGTTVKNLENNSVLVDFVHDKQSFILCFGGKGGKGNAAFKSPIMRAPNLYENGDKGEILNVSLEVKYLANVGIVGFPNSGKSTLISKLSNAKPKIANYRFTTLIPVLGVVKYQNNSLVFADIPGLIENASEGSGLGHDFLRHIERCEILIHLISLDPVDNDDPCKAYLQIMDELSKYSPLLVKKKMLVVANKIDVNEGEKRFKKLEKFLQKKSISVLKISALKKELGNLLDRVFELYNKTISQFGANKFSLPMELEKHYVFQNTNENNNDPLNIEKDSLNRWIVNCKRLRYWFDKIPQTTLDNIRRLGNKIKEIGIEDQLKSVGAKKGDIIFFDGCEFVIND
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MKIKVNTSEFLKAIHAVEGVITTREIKSILSNLKIEAEGKETFLSATDLEISIKTSVPADVTQEGNVSLPAKQLSSFFKTIHFEDTNLSLEESDSNSSIVYITDASGKNDYKSKISGMDADEIKTISKIDSSQVSSFPSTLINDMIRKTSYAIAHEDQRFIFNGLYMIPNGDKLIFVGTDGRRLCKIERTLPSPLQFKDSIIVPAKAIREISKMIATSEVGNIGLIDGQIYVSANNIELLCKLIEGNFPNYEQVIPKNTKFSTSISKEEFQVSLRQVLTAAEEPSRQVRLTFSKNNLNLFAQTLGASEASINKPIEYSGDEVTIAFKGEYLMDIFRSIDDNEVKIEFSDANSPVIFKDPSDPEFISVIMPMKL
The following text describes a protein:
Function:
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
Sequence:
MATKSITVKEEEAFQSLSKPIHICIVNATNPVAYHLIPHLGNGKIFGSEVEVSIRLLGIQKADETLQGVKMEVEDLAFPLVRKIEIFKNSRKAFQNASLIVFLENPVEDESHLELLVKNHERYKKYAEEINQVALPDVKIVLSGSGPINFNTHVLVEYATKINKQNVVAVSRLQERRAQAALARKMQVNASGVTNVVSWGNCANDAAKNTYCIDVLSAAVRGYDGAIWGPQWHSRSLAELVYDKKWLNDEFVEEHASHNAKMIKSMKHSTSLSEASSISSMLHDWIQGSESENVYSLGVESEGWYGVSGCVFSMPVQFKDGSYQVVWGLTLNDEVRDKIKKIELELNYNRTYCVSCCVS
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). Acts as a positive regulator of trichome branch initiation. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Miscellaneous:
MISCELLANEOUS: 'Furca' means two-pronged fork in Latin.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell membrane.
Sequence:
MVLGCPKREAVKEFGVQCLKQENVCPIITSRNQTHTHTHITISSSLTLHNGGLSLQKIIMGKTSKWFRSLLTGKKERTKEHIIQSECVFTSSIPGTPKEKRRWSFRRSSATGPPPPACAITLKDSPPPPPPPPPPPPLQQPFVVEIVDNEDEQIKNVSAEEIEEFAAIKIQACYRSHLARKALRALKGLVKLQALVRGHLVRKQATATLRCMQALITLQAKAREQRIRMIGGDSTNPRTSIHKTRINNFYHENEENIKIVEMDIQSKMYSPAPSALTEMSPRAYSSHFEDCNSFNTAQSSPQCFSRFKEYYNGDTLSSYDYPLFPNYMANTQSSKAKARSQSAPKQRPPEIYEKQMSGRRRSSMEAPRNNGVPRAVRMQRSSSQLGSNTAKESQQHHHHQYYPWMAIKLDRSNISLMESECGSTSTVMTNTNYGRHVDVQGNNNMY