lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
Miscellaneous:
MISCELLANEOUS: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
Subcellular Localization:
Mitochondrion outer membrane.
Domain:
Consists mainly of membrane-spanning sided beta-sheets.
Sequence:
MAPAAYSDLSKASNDLINKDFYHLSTAAVDVKTVAPNGVTFTVKGKTTKDDTISASVDAKYLDKATGLTLTQGWNNANALNTKIELSELLTPGLKGELDTSVVPNGARNAKLNFFYQQSAVNARLFFDLLKGPIATADLVVAHDGFTAGAELGYDISSAKVNKYSVGVGYANLNYGLAATATSNLSVFSAAYFHKVSPLVQVGAKATWDSIKSSNVNVEFATKYALDNTSFIKAKIADSGLTALSYTQELRPGVKLGLGASFDALKLAEPVHKLGFSLSFAA
The following text describes a protein:
Function:
Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MSSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQIFVDRDGDLFSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPYLLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFTEQPSAPTWNGNFFPPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTGVRYVSIKPDNRKLANGTNVLGLLIDTLLKEGFHLVSTRTVSSEDKTECYSFERIKSPEVLITNETPKPETIIIPEQSQIKK
The following text describes a protein:
Function:
Plays a critical role in endothelial cell capillary morphogenesis.
Subcellular Localization:
Secreted; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells; [Isoform 2]: Secreted; [Isoform 3]: Secreted; [Isoform 4]: Cytoplasm.
Sequence:
MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDRTQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGSFTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHSTYAEVEPSGHEKEGFMEAEQC
The following text describes a protein:
Function:
Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSASNVSLLHETCRQVAAGGCAGLVEICLMHPLDVVKTRFQVQRSVTDPQSYKSLRDSFQVIFRTEGLFGFYKGIIPPILAETPKRAVKFSTFELYKKFLGYMSLSPGLTFPIAGLGSGLTEAVVVNPFEVVKVGLQVNRNMFTEQPSTFAYARQIIKKEGWGFQGLNKGFTATLGRHGIFNMTYFGFYYNVKDNIPSSKDPTLEFLRKFGIGFVSGTVGSVFNIPFDVAKSRIQGPQPVPGEIKYRGCFKTMETVYREEGILALYKGLLPKVMRLGPGGGVMLLVYEYTYAWLQENW
The following text describes a protein:
Function:
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site; MISCELLANEOUS: [Isoform 3]: Due to intron retention.
Subcellular Localization:
Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MDLTLSRADYLQVGVTSQKTMKLLPTSRQRATQKVVVGDQDGVVICFGVKKGEAVPVFKTLPGQKISRLELGGAVNTPQEKIFIAAGSEIRGFTKRGKQFLSFETNLTESIKAMYISGSDLFLSASYIYNHYCDCKDQNYYLSGDKINDVICLPVEKLSRVTPVLACQDRVLRVLQGSDVMYEIEVPGPPTVLALHNGDGGDSGEGLLFGTSDGRLGLIQITTSKPIHKWEIRNDKKRGGILCVDSFDIMGDGVKDLLVGRDDGMVEVYSFENANEPVLRFDQMLSESVTSIQGGCVGKDGYDEIVLATYSGWVTGLTTEPTHKESGPGEELKLNQEMQNKISSLRSEIEHLQFKVLQERENYQQSSQSSQAKSTVPSFSINDKFTLNKEDASYSLVLEVRTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDTESNDNFLLATYRCQANTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGECATFYFQNTFLDTQLECVYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTDFLTPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPMLLEILDSYDQNTLISFFDAA
The following text describes a protein:
Function:
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLDIQSTELNAAKWKELVSSLHQYKTIRLDDCSLSTKHFKDISTVLTKNQVLTELKLNNNEVGDSGMDVLCKGLLHPSCKLQKLWLQNCNLTEACCEHLRSVLSSKTSLTELHLGDNTLGESGAKVLCQGLLDPNCKLESLQLDYCELSAANVEALSSALRTKPSLKELSLCNNSFGDAAVKLLCQGVQDSKCNLQTLRLENCDFTAESCGDLGTILSTKPSLTELCIGENKIGDRGVALLCQGALNPNCHVQKLWLWECGITAHGCKDLSNLLGNKETIKEISLIGNDVKDQGMDFLSQGLKNPKCKLQSIWLRECGLTGTCCKSLSQALSTNGTLKELHIGGNQLDDAGVVQICEGVLSPTCNLQSLSVGQSKLTAACCDKLAEVIAGKPSLQELDVSYSHIGDEGAMKLCEAVKNPNCHLKYLILYDTFWTTPVDKELKALDELKPGFKLVT
The following text describes a protein:
Function:
Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
Subcellular Localization:
Cytoplasm.
Sequence:
MYKIGIILGTRPEIIKMSPVIRELTTKKFFLIHTNQHYSENMDKIFFEELNLKKPDYNLNIGSGSHGDQTGRMLMEIEKVLLKEKPDFVLVQGDTNTVLAGALAASKLGIKIGHIEAGLRSFDRKMPEETNRVLTDHISEFLFAPTKTAANNILKEGISDEKIHIVGNTIVDATIQNLKIAEKNEKVCKFISKITKNEKYFLLTLHRAENTDNFEILSKLVTSINNISKKYEKNIIFPIHPRTHKKLNEFGLINKLENNHLIKIIEPVGYLEFLGLEKNAELIITDSGGLQEEACILNVPCVTLRENTERPETLDVNSNILAGSDPENILNCVEKMLKSNRHWNNPFGDGNSGKIIVNIVFGEKKP
The following text describes a protein:
Function:
Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRPGGALLALLASLLLLLLLRLLWCPADAPGRARILVEESREATHGTPAALRTLRSPATAVPRATNSTYLNEKSLHLTEKCKNLQYGIESFSNKTKGYSENDYLQIITDIQSCPWKRQAEEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGEAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQFSKCEVA
The following text describes a protein:
Function:
Involved in efflux of 2-nitroimidazole.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTCSTSLSGKNRIVLIAGILMIATTLRVTFTGAAPLLDTIRSAYSLTTAQTGLLTTLPLLAFALISPLAAPVARRFGMERSLFAALLLICAGIAIRSLPSPYLLFGGTAVIGGGIALGNVLLPGLIKRDFPHSVARLTGAYSLTMGAAAALGSAMVVPLALNGFGWQGALLMLMCFPLLALFLWLPQWRSQQHANLSTSRALHTRGIWRSPLAWQVTLFLGINSLVYYVIIGWLPAILISHGYSEAQAGSLHGLLQLATAAPGLLIPLFLHHVKDQRGIAAFVALMCAVGAVGLCFMPAHAITWTLLFGFGSGATMILGLTFIGLRASSAHQAAALSGMAQSVGYLLAACGPPLMGKIHDANGNWSVPLMGVAILSLLMAIFGLCAGRDKEIR
The following text describes a protein:
Function:
This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNLIIFAAFVIAAGLTVGLASIGPGVEGIARQPKTKGKIRGTLLLSLVFMEALTIYGLVVALTLLFANPFV
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSTVRRERSRFLWVQLSLCPVIIVVGTVMRIFSEPNSWNADKDSTVNIWFIKQGWAWTSAVCWWCVVRYKGLGGRSLRQTALRYVALTAWWYAFTQAIWFGIAPIMDQVFTSTGGHCSFDVFDTGMGLNSGFHDSEGRRTRSLQKLLQWFTAHGAQGDELRERTMYWIRCMLTGGQCENTGLDPTELNSYIQDSVTASAIRSSHACSRLGGHWMGGHDPSGHVFLITLMCMFMLGELQVFGRRAIGKLSADCQQLQGAPGKIVARILQASPIRELINSEAPQHILRRLFVQLPLESLAILVSAVVFGFRFIVLENPILLLVGLILTWTWSLLVTILSFHSFAEHLTGLLFAYLLVLALYWYI
The following text describes a protein:
Function:
May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors.
Subcellular Localization:
Early endosome. Mitochondrion.
Sequence:
MSGQVTQPKLIKDWTKEHVRKWVTEDLNIVEKYAQILFKEEVTGMVLQELTEEDLREMGLPRGPALLIKRMYNKLISSPESHNQDSRELNDKKLSTKEQQTKTKNEEENSVSSNSDHGLRETGQNEEQEPSLTKENMLGDVVTKDMEDNKPKPEQMSCTPYPFDSFCDVKQYIEHSILRVAETGPLNLIDPIHEFKAFTNTKKATEEDIKMKFSNETFRFAAACMNSRTNGTIHFGVKDKPHGEIVGVQVTSKDIFVNHFNTMITKYFEDSEISEARACIREPRFVEVLLQNNTQSNRFVIEVDVIPRHSICQEKYFYIMMQSSTGKTWKQSKDTSLFVREGASSKNILGNPNQRDREFKKFLEDLKMWTASRKAAEEELRMVTKKESEGLKLSKLLTRHQGSLDESYYDWYILVTNTCAPTQLEHLEFIKEMKLFAVLDFDPYSHIKGVVKAYRESRIANLHLPSHYEEKTTIAEKISTLKLYEQPSWIFCNGRVDLSCQPLEPHLWQRDRASGVRRLISFLTDENIIVKGKVLVVFLLLSPIENQKDPLIETFCAFYQVFNGMDNMLCICVNSAIYQQWSDLLQVRLEIKDDLAKHSISTLNIELVNNTILKLKSVIQSSRRFLPSCGSSSVILEKMDEDIMSALEILCENECKDTDIEKDESQFLEFKKSREEHFYRGGRVSWWNFYFSSENYSSAFVKRDSFEELTTLIQQCADSPKPVFVKVINLYHHPGCGGTTLAMHVLWDLKQKFRCAVLKNKATDFVEIGEQVSKLMSYKATSHEDFIPVLLLVDDFEEQENAYILQNAINAFIAEKGLRYEKTLVIILNCMRSQNPDESAKLANSISLKYQLSPKEQRAFEAKLQEIEKEHKNCENFYSFMILKGNFDTTYIKNVVKNTLKDLDAKSRRAQLISYLALLNSYVTDSTISVSQCEIFLGITYTKKYGKPETVEKNMGTYSTLLIRTEVSDYGRYTGIRIIHPLIATHCLKELEMSYRMDKCQIALNMLEENVLYDSGLGRDKFKYDVQTLLLTRQRKEHGAETDTLFSPLIEELQNEETEKVLIAGSDRFPQNAFICQALARHFYIKEKNFSTALVWANLAKRKAPKNSYISDTLGQVYKSELNSGWEVAEKASKAFKESQNQSDSKDYGTEAWSPQNSQRRYDTFNTAGFFGEIEVGLDTIQLLQLTPLFHKENEISKESMAEFLSGKGTILSDPKGEYCVVLSKFTSLLQNLHSDLERCFHFFGDYMGFLKPRNTPKELTELLLSKKVSRCFKKYVELFCHLDTNLVQGKEDLLLQKENCRKRIQAWRADTFSGLLEYLNPNHKEANNIENIVGNYTFLLQDILNKQLSKVLTKDIQNFILANIILSCLKPSSKYILPFSTLKKKLREVLQIVGLTHSYPDPYFLACLLFWPENKELDEDSTLIEKYVSSLNRSFRRQYKHMCRSRQPSTLFYLGQKKGLNSLVHKAEIERYFSEVQDSNSFWHSGVVWEKREVKDLLRLLDGQAEGKLISLEYGTEAKIKIPVTSVYSAPLRSGRNIERVSFYLGFSIEGPLAYGIKVI
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins smb1, smd1, smd2, smd3, sme1, smf1 and smg1 that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins smd1, smd2, sme1, smf1 and smg1 (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone saf5 (By similarity). To complete assembly of core snRNPs, the SMN complex accepts 5Sm from saf5 (By similarity). Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of smd3 and smb1 to complete assembly of the core snRNP (By similarity).
Sequence:
MDSHTTEKRRGSYLRVLFKNGRLPVEGFLWNCDPLTGTLILIQPLTPNTDEVEDTHYRFYGIMSDAIQTIEPDESMSPLNQQSLAEYDSLLTS
The following text describes a protein:
Function:
Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Converts phenazine-1-carboxylate (PCA) to 5-methylphenazine-1-carboxylate (5-methyl-PCA).
Domain:
Contains an N-terminal dimerization domain. The C-terminal region contains the S-adenosyl-L-methionine binding site.
Sequence:
MNNSNLAAARNLIQVVTGEWKSRCVYVATRLGLADLIESGIDSDETLAAAVGSDAERIHRLMRLLVAFEIFQGDTRDGYANTPTSHLLRDVEGSFRDMVLFYGEEFHAAWTPACEALLSGTPGFELAFGEDFYSYLKRCPDAGRRFLLAMKASNLAFHEIPRLLDFRGRSFVDVGGGSGELTKAILQAEPSARGVMLDREGSLGVARDNLSSLLAGERVSLVGGDMLQEVPSNGDIYLLSRIIGDLDEAASLRLLGNCREAMAGDGRVVVIERTISASEPSPMSVLWDVHLFMACAGRHRTTEEVVDLLGRGGFAVERIVDLPMETRMIVAARA
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MMCSINEENLAEETMVATPKLSVTDAICRRCNILKAQVLLRKTDPYCRDCFMKYAVHKFRSTIGKAHALKHNEHVLLAYSGGLSSGSMVKLIKEGLDFSESKKIKMVFKPTLVHIDEGLILNLSKHERKETTDFVLEQAKKNGFDVYICSLEYCLAPDLNDLKLEMNSYQIEPSIYESQLEMLFGSVKSLTAKEDLLIRLKQRLITLLATRLNHAKVFLGPNATRLAGQLLSAIGQGRGAQIAHEIGFTDSRTGTVFLRPMREFVDKEVAYLANFLGVDSVCLPTLSSKLGSTASIGRLTEDFVVTLQTNFPATISTLFRISDKLKSNIADLNPSDCERDSLCLLCLSAIEESSVCSASTARHISQTFSRSGPSGHPSDDLRTHPLQSVGTVRHQDSTSCSSNCNSQGKPCCKTSNDQIKSDWSAVLCYGCRITMEDVKQPELMPINYLEELGLRSRRQVMRQSVEQFLL
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MDSSSGTLVPANLWRTFAGNTAKVPSPNSLVYYFPQGHAAQASSPPNFPNGPHFPPCIPCLVYDVRLFASHQTDEVFAVLSLVPDTFSIREKPATTDFFADLAEIDSHAKVLTPSDSNNGGSFSVLSQMAESVFPKLDKSIKNPEQDLVMQDVHGKAWKFRHIYRGRPKRHLLTTGWSKFVDEKRLASGDTVVFARGNDGMMSVGLRRRAEVSQFRTHWLPPEDVVRAAEHAASGHPFQVVYYPNRGSAFCVERHIVDMALELSWVPDVTIRMTVEGVKGLVTGSVLSVSVVDPDRWPGSPWGLLEVASDRSSTRRVNPWSVESMKVLSPLLYNEQDKPSTVAENEKFESLLGPQLSTYKEHEMGLHIDKRQFKSNSSTTTIQEARQDPIIKALSSDSLDNQTCNKSTFCDNHSNQQNSFGMPLMLPTLECFSPQGYSNYQSQSDGNLPKKCDTELPGSGSNDVAIKSNIFKPSEKSRSMVQPQETSNDKPEKEANVRLCKVFYNDIIGRSIDLSLFCSYEEFFGRLSHMFGKEISPLHSLLFYDRPDGIQRSVGEEPYNISLWEGLLKFFYEMLDVLGEVEGYASIMWHGVKNNGLENDSTGI
The following text describes a protein:
Function:
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex (By similarity).
Sequence:
MAKKMKLSEITNMFAGMNVEALEGVTIEGDIEIDLGGLGGFDPMLAAALGQESAVLAQHFARIAGMFGYPVSVGAPAAAPAAVSPALAAPKLKDLIPAKFEFSNIEEWTTQVEEVPIGNTSADGGSRGKRILLGGEKALPFFPDAPMPNRNQVTIDVFDMRLGLAKAVKENYDDVMDNPGEWAKKNVEKFNADMITIHLISTDPLIKDTSPKDAAKTVEEVLQAVDVPIAIGGSGNPQKDPLVLAKAAEVAEGERCLLASASLNLDYAAIAEAALKYDHDVLSWTQLDMNAQKELNRKLMKQCNVPRDRIIMDPTTAALGYGLDYAYTNMERIRLAALMGDDELTFPMSSGTTNAWGARESWMVSSPLKEDSDWGPREYRGPIWEIITGLSLAIAGNDLFMMMHPTSVAVLKHMTQTLFGSIEAEPVDIANWIGAEV
The following text describes a protein:
Function:
Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes.
Sequence:
MAYRSTGIARQLFNTAAVASCTSKPTAVPVARTFASVPSRSNASTSSSVTLDQLRKPSQPSASIENGSLTATVTAAESDAVSAAPDEEQFVLPNCLLPTEALGRTHGIHVATLHLRSYEDGRDNLELFADFARRAAFAIGIAASGVASLPIRTSLWTVPRSPFVHKKSQENFWRKTHSRAIKLYDANDQVVDRWLHFLRIHALPGVGQKAELFRYHEVGVGGKLMEEAKALQRSSTTVLGGEKKGTDVSPPQGSAAESIKKIADRIVENEIATETPSELK
The following text describes a protein:
Function:
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLLDARKDHYRKLAHEQGFRSRAAYKLKELNQSYRIIGPGFYVLDLGCAPGGWTQMAIKLAGNQGKVMGIDLSYVEEIPGAEILRGDIEDENVVDDVMNYFERKVNAVICDLSPKVSGNWSVDHAKQISLNYDCTKIMDKVLAHKGNAVFKVFDGEYSMEFRDYVKKKFARINLTKPKASRKQSSELYYVCLGFIG
The following text describes a protein:
Function:
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein.
Sequence:
MYFKNFLYSLNKNIINLNPKFLDRPLIYKKINLTTATLPSLSHSPRLLHVVVSPMLSRSTASPPPLFLRCSFRRSSPHGCSNKFQTFGASLPSKARQSRRLHASLVDPSDSCYILSSRLDGRIALSFRGNCEFTEKAKHAEAAGASALLVINDKEDIDEMGCVEKDVSLNVTIPVLMISKSSGYALYKSMVEHKSGLLLLMAVGTVVVGSLWSELKDPDQANESYSISSKEKEILYISVTGAVFFIVTASVFLLLLFYFMSSWLVLVLIIFFCIVGMQDMHKIIMAVLLRKWRHLGRKTVKLPLIGTVSWMSVAQGDRSSGESMPMLLRIPRFFDPLGGYHMIGFGDLCVPGMLICFASRYDKFKKRVVSSGYFLWLTIGYGVGLLLTCLGLYLMDGHGQPALLYIVPCTLGLAVIMGLVIGELKELWNYGIEESESHTPEDPLPVA
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRPSAAPGDGGAINWTADRLATPETVAGPSTEPSDQAKDIPVAFDPPQRDSASDHLKPSQANHTSQHSWSIQAQTHSILIFSAIWGLLTRLGITAIGNFSGQNVFSLLLVQVVGCLIMGTSVSLQTRLGKIHSLLYFGITTGFCGSVTTFSSWMLQVFQAFSNTSKFSRGRFSDFLDGLNLTYVTIALCLFSLQTGLFLGNVVENIIASRTRATNLNTSTCSSRRDTFAHRKIPTILIILTGPLTWLGSVFLFIWGPNGWRGPVTYSMIIAPTGTVMRYYLAKFNTRRLSIDKGFPTGTYLANVIATALLALFSALQYTSAARNDREYCAGLQGLRDGFCGCLSTISTFFLELHRAGPSYKNFRYGLTSWLSGQFLYLMIFGIYFWTRDPQERCAFST
The following text describes a protein:
Function:
Plays a role in fertilization through the acrosome reaction.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane.
Sequence:
MKHHLIEHRGEQTPGTAVGMASPDAAEESTGVCWPGGAMRRNESSPRPGPAFLPDDDIYLAARAQGVLGWSSSPSSQSSSEYQSYSQYQSWDSSKSEEQQETPPESVCALYTHVQTVRGVAVAWETDDGFEPVTRKPLIREAEFIKRQRRKGSSFEMASNTDLRWELEDCKHYCPQTEDPVDCCMQELRAPPDWLVTTNHGLRCVACCRVFPTLEALLDHAQHGIQDGFSCQIFFEEMLERKRTRDQKQDQQPVEEEQSLSDSSECTRLLTKVLPWQQQPQQQPQEQQKQQQQQQQKQRQQEQQQHQQQQQQPQPLKQQQQQQQQQPLQPQPLKQQPLQPLQPQPQPQPQKQQQRQQQRQQQPPRQQQKQQPLQQQGK
The following text describes a protein:
Function:
Male determiner protein (M-factor) that controls male somatic sexual differentiation. Acts as a dominant factor that regulates the mRNA splicing of transformer (tra) and doublesex (dsx) transcripts and promotes expression of male splice forms of tra and dsx (By similarity). Probably acts as a component of the spliceosome C complex required for mRNA splicing factor and exon-junction complex (EJC) assembly (By similarity). Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs (By similarity).
Miscellaneous:
MISCELLANEOUS: The M.domestica genome only codes for one male determiner Mdmd protein, which is encoded in the M region, and can be located at different loci on the genome (chromosomes II, III, V or Y). The M region contains a cluster of tandemly repeated Mdmd copies with only one intact copy: other copies are degenerate with large truncations and frameshifts and are assumed to be non-functional. The presence of multiple copies in the M region may preserve its integrity in a hostile non-recombining environment. This protein is encoded on chromosome V.
Subcellular Localization:
Nucleus speckle.
Sequence:
MNATDAESRKPENKPSSESSSSGSTSGSSDGEVSSKTYFKNNKSKVLSGQREVVLEVVRDLSYTICKEAEEKLVERFPRKDGSNEMLPKEDSINTNHNYTTDSNEHPVELTTKTEECKNTEKTKKKSFVRALSKDKQLSAYRSRSRSTRLSYSGHISRTHSVEKSLSRYKKSVLRSRRTSFGHGRDSSTTKRSVSRDKDNRLRRRIGSSRSHTRSHSRFRRSEKKLPSRSPRRIRSQERRHERRRSMSSDYERIALRRSEPIKRRDKDEFFKNNKKVSGDIKKGKGNDNGTVAELEAKITERQRKSLDILTSRTGGACLTPDKLRMIQAEITDKSSAAYQSIAREALKKYIHGYINKVNVDSVAVITRKLLKDNIVRGRGVLCHSIIQAQATSPTFTHVYAAMVAIINSKFPNIGELLLKRLVIQFKRAFGCNDKTVCLTSSHFIAHLVNQRVAHEILALEILTLLIESPTDDNVEVAITFLKECGMKLTEVSSDRVGGIFELLKNILHQGKLDKRVQYMIKVLFQVRRDGFKDHQSIIESLELVEEYAQFTHLLLLEDVTYPKDILNEFKFDDQYETNEEKYKALSKNILGSHASDSDGSFGSGSNSETALSDCDKGKNEVNDKYTSGDIIDETKPNLIALRRTIYLTLNSCLDYEECAQKLMKMQLKTCQQNEFCQILLDCCAEQRTYEKFYGLLTHRICKMNKSFIEPFKEIFKDICQTTHCLDTNRLRNISKFFAHLLFTDAISWDVLDCIKLTEDEAITSRCIFIKSFFQELVEYMGLYHFNKKLKTEVLAGTLAGLFPKDNPRNIRFSINFFTSIGLGGITNELCQLLKIAPKSAPSSSSSSSLSSELSAPSDDDSSSDSENKKKHKGKNKKMTKKKNPSKKKEKTKKIVGKNKIAAKNKTIKRRTDKDNSSSKDNFLKSESSSNESISLDSLSSELFAPSSYSSSESSNDSESKEKHKGKNKKMTKKKNPSNKREKTKKKLSKNKKAPNKNTKKRMTEKDISSSESSISESKSLNCSASNQNENEKRKKRVTSKSRTKRVKMFKQCQWVDADNQRDIKRKKRAEYRYEPLVYRKRNEECLKKGAPNCRKDNYGNRQNHEISQRHDSEIKRRREERKKRHHEKNHSREYKRSKLGLCQREYFLYMCCQFYYPCTFQCLCQNCHFTFYS
The following text describes a protein:
Function:
Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in M-factor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGNLHTSIAVASICLTSAFLGCVFGLGFFVWIIYGYSIGGFFAFLSLFHLLEFYITARFQGSQLSWDSFILNNGKAYWLAMLVGLLECLLSGGKSFAKVINCLRFPSFLINFIFSVYQTSALGFLCLGQYLRSSAMVQAGQSFSHIVASKRNKDHLLVTDGIYAYVRHPSYVGFFIWALGTQMLLGNFVSTLLFSLVLWKFFSQRITTEEAYLVSFFGDSYEQYRKKVPSGIPLIP
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.
Sequence:
MSFPTLHARAEAKPLEHRSALTPTTAKKLLDAGYPVLVERSPKDPNYARIFKDEEFEQAGATLIEEGAYKTAPKDRIIIGLKELPEDEFPLEHTFVHFAHCYKQQGGWEKVLARFPRGGGTLYDLEFLQDTTGRRVAAFGYHAGFVGAALAIKTWAWQLTHPNGEPLPGVETFTDGRGYYNNESELITQLKEDVAAGEKVAGHKPSSLVLGALGRCGSGAVDLLEKIGCPEIKKWDLPETKERDGPYPEIIESDIFVNCIYLSKPIPPFVNKESLKSPKRKLSVVCDVSCDTTNPHNPIPIYDINTTFDKPTVGVDVEGDGPRLSVISIDHLPSALPRESSEAFSNALLPSLMALKDRATTPVWQGAEKLFQEKVQTLPGGVPKKEV
The following text describes a protein:
Function:
Involved in both selective and non-selective autophagy. Does not appear to play a role in determining the size of autophagosomes, but rather influences their formation rate. With ATG9, plays a role in the delivery of donor membrane to expanding phagophore.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Shows a peri-mitochondrial distribution similar to ATG9.
Domain:
The C-terminal 10 residues are required for the association with ATG9.
Sequence:
MSSVESSPISRYEDEVFPLSFSNVAFEPPMLSHSPDRSTYADDFSQSYQQELLTFPLSYPIVDESECTHTKDKTDSNIITSTEDDCMFDMEFNGNAASAVAAASKESNSASGFAFASNDAFANVAQQNYRLWLSSV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Domain:
The RING-type zinc finger domain is essential for ubiquitin ligase activity; The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.
Sequence:
MLFFTQCFGAVLDLIHLRFQHYKAKRVFSAAGQLVCVVNPTHNLKYVSSRRAVTQSAPEQGSFHPHHLSHHHCHHRHHHHLRHHAHPHHLHHQEAGLHATPVTPCLCMCPLFSCQWEGHLEVVVPHLRQIHRVDILQGAEIVFLATDMHLPAPADWIIMHSCLGHHFLLVLRKQERHEGHPQFFATMMLIGTPTQADCFTYRLELNRNHRRLKWEATPRSVLECVDSVITDGDCLVLNTSLAQLFSDNGSLAIGIAITATEVLPSEAEM