lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the mineralization and structural organization of enamel.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MSALKIPLFKMKDLVLILCLLKMSSAVPVFPQQPGTPGMASLSLETMRQLGSLQGLNMLSQYSRFGFGKSFNSLWMHGLLPPHSSFPWMRPREHETQQYEYSLPVHPPPLPSQPSLQPQQPGQKPFLQSAIVTDIQDTAQKRGTQPPVYQGQPPLQQTEGPMLEQQVAPSDKPPKAELPGMDFAEPQGPSVFQIARLISRGPMPQNKPSPLYPGIFYMSYGANQLNAPGRLGIMSSEEMAGGRGSPMAYGAMFPGFGGMRPNLGGMPHNPGMGGDFTLEFDSPVAGTKGPEKGEGGAQGSPMPDVNPANPENPALLTELAPGALGGLLAHPKDNDPSLARGPAGQSGGPPRVTPADADPLMTPELADIYETYGADVTTPLEETPTDTTVIPDTQQTLMPENKAQQPQIMHDGWHFQEP
The following text describes a protein:
Function:
Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network.
Sequence:
MSRNDSKYFSTTKKGEIPELKEELNSQYKDKRKDAVKKVIAAMTVGKDVSSLFTDVVNCMQTENLELKKLVYLYLINYAKSQPDLAILAVNTFVKDSQDPNPLIRALAVRTMGCIRVDKITEYLCDPLQRCLKDDDPYVRKTAAICVAKLYDINAELVEDRGFLDSLKDLISDNNPMVVANAVAALAEIQENSSRPIFELTSSTLSKLLTALNECTEWGQVFILDALSRYKAADAREAENIVERVTPRLQHANCAVVLSAVKMILQQMELITSTDVARNLCKKMAPPLVTLLSAEPEIQYVALRNINLIVQRRPTILAHEIKVFFCKYNDPIYVKMEKLEIMIKLASDRNIDQVLLEFKEYATEVDVDFVRKAVRAIGRCAIKLERAAERCISVLLELIKIKVNYVVQEAIIVIKDIFRRYPNTYESIIATLCENLDTLDEPEAKASMIWVIGEYAERIDNADELLESFLESFPEEPAQVQLQLLTATVKLFLKKPTEGPQQMIQVVLNNATVETDNPDLRDRAYIYWRLLSTDPEAAKDVVLAEKPVITDDSNQLDPSLLDELLVNIATLSSVYHKPPDAFVTRTHSSAQKTEDDDYPEGSETGYSESPGNPANGPASPPSASYSAPASVAPASPPPTAPVPDLLGDLMGTDNSSIVPLDEPATSTGPPLSIVLPTSVGHGFQISAQLTRQDGQIFYSMLFENNTHVPLDGFMIQFNKNTFGLAAAGPLQVPQLQPGTSTRTLLPMVMFQNMSQGPPSSLLQVAVKNNQQPVWYFNDKFSFHVLFTEDGRMERSAFLETWRSLPDSNEVSKDFPDIVIGGVEATLDRLAASNVFFIAKRKNANQDVFYFSAKIPRGIPLLIELTTMAGNPGVKCAIKTPSPEMSAFFFEAIETLLRS
The following text describes a protein:
Function:
May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKHEENRETVSSVSKILGLLLAASSCVFFAISSLFVKLLGEIPPQEVVFFRSLVQLIFLLPPVIYSQSPALGERRQLPCLIVRGLAGTLALCCQFYAFQRIPLADATVIVFSSPIFTGILGYFILREAWGWFDAVATMLCFFGIILIVRPTFLFGREAGGLSSSDNWQQLTASLVALCGAVMTSIALIAIRKLQGVHCLTPVLYLAISGVVSTAIGVLVTGTFRSVRCGSNHQWLLLALGLCGIGGQTLLTKALQLERAGMVALVRTLDIVFAFLLQLAFLDYRANVYSVIGAVMVVACNVIVIASTW
The following text describes a protein:
Function:
Acts as a gatekeeper for degradative protein sorting to the vacuole. Plays a role in recognition of ubiquitinated PIN2 auxin carrier at the plasma membrane and further to its endocytic sorting. Binds ubiquitin in vitro. Might contribute to the loading of the ESCRT machinery (Probable).
Subcellular Localization:
Endosome, multivesicular body. Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Sequence:
MASSSASATVAVDKATSDLLLGPDWTTNMEICDSVNSLHWQAKDVVKAVKKRLQHKSSRVQLLALTLLETLVKNCGDYLHHQVAEKNILGEMVKIVKKKADMQVRDKILVMVDSWQQAFGGPEGKYPQYYWAYDELRRSGVEFPRRSPDASPIITPPVSHPPLRQPQGGYGVPPAGYGVHQAGYGVPQAGYGIPQAGYGVPQAGYGIPQVGYGMPSGSSRRLDEAMATEVEGLSLSSIESMRDVMDLLGDMLQAVDPSDREAVKDEVIVDLVERCRSNQKKLMQMLTSTGDDELLGRGLDLNDSLQILLAKHDAIASGSPLPVQASGSPLSVQASKPADSSPKSSEAKDSSSIAGSSSPIPATVSTGKSPIDEEYEEEEDEFAQLARRHSKPPASVTTDPTSLESHNAASNALALALPDPPPPVNTTKEQDMIDLLSITLCTPSTPPAPSSQPSPPPPAGSDQNTHIYPQPQPRFDSYVAPWAQQQQPQQPQAQQGYSQHQQHQQQQGYSQPQHSQQQQGYSQLQQPQPQQGYSQSQPQAQVQMQPSTRPQNPYEYPPPPWASTSANAYYTPRANASASYTDTSALAGRSLQQSNSFPTRAGDPQATSTASNSGVSVGQKPFVPSYRLFEDLDVFGSADGKHNKPANSSNGSQNLSGSQTQQSMIGGRKMI
The following text describes a protein:
Function:
Mitochondrial DNA endonuclease involved in intron homing.
Subcellular Localization:
Mitochondrion. Membrane; Multi-pass membrane protein.
Sequence:
MRLLKTHPILGLANSYLIDSPQPSNISYMWNFGSLLGVCLIIQILTGVFLAMHYTPSVDLAFISVEHIMRDVNYGWLIRYLHANTASFFFIFVYLHIGRGLYYGSYKSPRTLLWSIGVIILVLMMAIAFLGFNGQKYMCFYNIDITIIQYLSIPTLITPSTRLKPILDKHNIKPVLLFENLTNSETKKIAYQALKPFSGIYMIVNLITEKYYVGSAVTGNLYMRFHKHLFSFTGNKRVANAVNKYGLSEFAFLVLEIVPQKDKIDSTLLLNREDYYLETLKPEYNIAPLASNSLGWKHSEESLAKMRENYSEERRQQVANINKGKTLSEETRELIRKSALLRKSMSSETRMKCAVNVQPVTIINLDGTNIMNFVSIKEASIAISCNEKTIRRALNGNGIVKKNYIVKVIK
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
Sequence:
MRRDINNFLFGERMELFEILKQKIKEKEVITPKEMAIIDDNAEFLGIQKILLMENAGKAVYEEIKDIDAEEFIIFCGTGNNGGDGFVVARHLGKGDVILIGKESEIKTYEARENFKILKNLAEFGNIRIREIKWAEEVNDIFERLKNKKAVIIDAMIGTGVKGELREPFKTIVDKINELKQINKNIFVISVDVETGHLESDLTITFHKRKTINKDNAIVKKIGIPKEAEYIVGWGDLKALRKRDSNSHKGQNGKVLIIGGSKDFYGAPILAGLAALKIVDLVGILSVGKVIDKVNHPEFIMYRVEGDYLSSQHVDYTLEIAKKYDVVVLGNGLGANNRTKAFLNEFLAKYDGKVVIDADAIKVIDYNNFEFSENYIFTPHKREFEYMGIDLDNIENIKSTIVLKGKYDIIFNANNLKINKTGNAGLTKGGTGDVLAGLIGALFAVNEAFLSACCGAFINGYAGDLLLKEKGYYYTPLDLIEKIPNVLKIFQ
The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MIGFIGMDALYVVNPSLLTLVLSLHLHFYLLVGAAMDSCYDEGGIPSHCMPKFENIAFNRTVEASNVCGSTPEDYCMQTGSTRSCHYCDASDPELSHNASLLTDFHRNEEPTWWQSQSMFYGIQYPKSVNLTLHLGKAFEITYIRLKFYTSRPESFAIYKRTEEGGPWLPYQYYSASCKKTYGKDAKGFIRPGEEEKTALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDQSLFLQEWVTATDLLISLDRLNTFGDEFFKDAKVLRSYFYAISDFSVGGRCKCNGHASECVEGERGDLVCACQHHTVGADCQKCHPFYQDRPWARATGDSANECLKCNCNGRSDQCIFDMEQYRSTGSGGRCVDCRDNTDGAHCEHCKANHYRVAPEDPCLACNCNINGSVSLQCNAEGRCVCRPGVTGAKCNMCQDGFHSLGPSGCRPCECHHSGSVGECSPLDGQCFCKRNVEGHRCGRCKPGFFNLQLQNPAGCQPCFCFGHSLACSSSNHYTPVNITSDFIEDQDRWVGEFFGGEEYILQWKEGEVYLLPLTEEDSGFYKAPDKFLGHQIYSYGQPLHITFTSETYDLLPNSLTVILEGSGMTLSADLYPKPILHPDPSNSPMQHFIVRLHEYETSFKPRLSAFELQHLLYNLTALKISNAGGHNYTSQLARVTLASASISSRPLSLPAAWVEQCSCPLGFSGQFCEGCAPGFTRQEPGGGPLSACVPCKCHQHGICDPETGVCECSHFTTGMTCEHCLPGYYGNALIGTPGDCQPCPCPDRSSCVQIAETGQVVCTNCPAGQTGMRCQMCEDGYYGDPMGQSGTVRPCVRCNCNGNVDFNAVGICDHFTGQCLKCMGHTEGDHCQRCQRGFYGNALEQTSGQKCKPCSCSSAGTSGHVNECHPQTGSCHCLSHVTGRDCSYCEVGFFNLQPGYGCERCKCSPIGSTSQACHPFTGECVCRPGVEGTLCDSCRLGFFGFSSRGCRACNCDPMGSVSMQCHGNGTCQCRQGFVGYKCDKCEVNYFHNRANHQCEECPVCYSLVKKQAEKLQTRLQDLEKLLSHFDCRGRLGRQPNLQQYHMAGFYQHDQLRGEDSLPNALEDFLAFQEAREAFIKQFSSLEAATGTLSAQLHGLTFTLNCSISVTQAEGSDGRKDERHGGVCRTFTVALLMIKASEKLLKQATLDLDNMIFPFETTSTPNKWNLMVNESQVLMESHREMADLIEAVATRALQASKQTFSLLMDLLRDNSTEEYIRNLTEQIAQMQQQKENLTLQLNETAAKQQALLEEDAVLSLTLNNITSSFHQLLLTDGRKSSEGGQTKFNQTSESNDTTEWGENLLKKSEELNQEIQTKDGLIGRIREKMEPETLAASENLEKVESIDQLKAQAQDLKVVALSSVVTGKEVESETISLYRRLENMVEEWPHLQAQTKAAVKKEKHLKEKVLPDARRKASQVKKSLQPAVENASLSNNATKEAKQRVHNVEKESKAILIQAKHTRTASGHLSSHIDSALKQLSEQESTLKKVKIPPPPEPEVSLTSIKEDVEAAKLQLEAYSTALTELISKIDGSVPLERFDRILNETARRLSMLRGSVESPALSSKIQKLHAAAKEQKSRLSLIEQDIQEIREERDSLRDIALNLPQSCPQNPGGGKA
The following text describes a protein:
Function:
Catalyzes a two-step oxygenase reaction involved in the synthesis of chlorophyll b. Acts specifically on the non-esterified chlorophyllide a and not on chlorophyll a.
Subcellular Localization:
Plastid, chloroplast membrane; Peripheral membrane protein. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Domain:
Consists of three domains A, B and C. The C-terminal C domain possesses catalytic function while the N-terminal A domain confers protein instability in response to chlorophyll b accumulation.
Sequence:
MTTVASLSLLPHLLIKPSFRCCSRKGVGRYGGIKVYAVLGDDGADYAKNNAWEALFHVDDPGPRVPIAKGKFLDVNQALEVVRFDIQYCDWRARQDLLTIMVLHNKVVEVLNPLAREFKSIGTLRKELAELQEELAKAHNQVHLSETRVSSALDKLAQMETLVNDRLLQDGGSSASTAECTSLAPSTSSASRVVNKKPPRRSLNVSGPVQPYNPSLKNFWYPVAFSSDLKDDTMVPIDCFEEQWVIFRGKDGRPGCVMNTCAHRACPLHLGSVNEGRIQCPYHGWEYSTDGKCEKMPSTKMLNVRIRSLPCFEQEGMVWIWPGNDPPKSTIPSLLPPSGFTIHAEIVMELPVEHGLLLDNLLDLAHAPFTHTSTFAKGWSVPSLVKFLTPSSGLQGYWDPYPIDMEFRPPCMVLSTIGISKPGKLEGKSTKQCSTHLHQLHICLPSSRNKTRLLYRMSLDFAPWIKHVPFMHILWSHFAEKVLNEDLRLVLGQQERMINGANVWNWPVSYDKLGIRYRLWRDAIERGVDRLPFSNQSESGS
The following text describes a protein:
Function:
Mitochondrial ribosomal protein required for central cell maturation. May work together with PIA2 in controlling female gametophyte development, possibly by regulating the expression of some mitochondrial proteins.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSRLFLRHSNLRFVTLVSSKSNSQIFSSFIRPLSTNSSGGGGNGDGNGRNRNDVPWSFTGVNDDKSGPFSSDDSFGSSGVAGSGLPGGEGKWPEEPKRWNIKEEEEKVVFDTGGEVGQGIETSRERRGNEWEETKRWDMKEGEEKVVFGGGGDEVDGFGIRGEVKSNEWDVSKPWNLKEEEEGVVFDTGGEVPFSFENSLEMAEEERVKKELIEKEEKELLEVIKGPDRAFGDLIAKSGITDEMLDSLIALKDFQGVEGLPPLTEIENLRREKSSKKSSRAEIELQMQEDIAKARVRQVDETGRAYGTGRRKCSIARVWIQPGEGKFQVNEKEFDVYFPMLDHRAALLRPLAETKTLGRWDIKCTVKGGGTTGQVGAIQLGISRALQNWEPDMRTSLRAAGFLTRDSRVVERKKPGKAKARKSFQWVKR
The following text describes a protein:
Function:
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MAGLRHFEEFDFDEDFDSEEEFSKFLSDEDFENESENESVDNESGVNMNFEKADIVELPDDIEIPPVAPQKNEETSLLDSLLGEALSGEQVNPSIVGLFDDLDLSDEEPQVINRGLLEDEDSGISTGPSRSDDTEISQESSSKIPEPSSIEKYLRYISEEEHEVSVDEIPDFASKKNVYGTSFNVRTGNISRPPRFEFARRDDRWINSCKLLTYDNEKPLNELLSLGKLVPTVKAGMKLNYKSCKFTDVHCRSAQEMSDMETHDIQQIIRDAFNSRRLAVILFGVDKDGIVTGCQMNAGKQDNLRLALDTAIQTEFVPPIENILDAVDVQFLPVENLGDMFLIVIRIKQIRNQHYLLESSMIPRKCTIRYGTSITPNFAKLIDAVPPSDADFNSSVVAVEKRIIENKDLAKLRRPSLSAILSAISDQRALYLWQKAKIDEMGLSSFKAYMTDRMAIGTRTHTRVEEMLRIGHDEAKLAQIIDSEKQAAIRNYMKSALPIILEIQDPESAICEKRVRHPILAYQGRFDAVVKYKDNWSILDWKTAPARSSFSQQGEDSLSYVSYVRQLAAYASAFNYDVRYENSPIAKQGLLVSLKEDGAPAEVYQISEDEMENTLGDVKEKLKKFWNKVMSSKQANIDLAYKPAN
The following text describes a protein:
Function:
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.
Sequence:
MSNFVEAVLEEMSWDRRYAVPELNEEHKALIEMIYKKEKQLAEVSARAETKKEQRKMMELKLQHSRQELENTEALLKANEKEIEFEQHLTALAERESGHLAQLTAKTEKELRSSKEKAEMIEENLSEAKEKLEKFRQQMQWDQQTMEAFLEESAQKEEDTMAMVKNSQQNKQKVKSLTLAIEKKRVELNENRKAYEKELTETTSVQVALKTMRDTMQQVHLDNQQLIQKWENTVKQMKRQDAEMQQCALELAQANQEVREKNAAIADLNQLLQTLQNNNKETEKKMAVTNRQAAKLQQELREEENICVKLQEQLDNCKRELDNINSGVRVLAAHISKSKKELQEKKDKVHTAEAYNAALREKLAKVSQLAEQDRVAELEQILREGEKAIKEVDVQQRFFMGELYLQKEQLKVLKGKEKESMVLISGAKVNMNTLQSRLGKLKTEMEEKDKVLRNQESELLTLKIKLARLQGDIPVDEKEMLKAKLAELTKDLEEKKEMDRMMSKEVKEGEHQIRCFRKILEKSEAQRREMLEKAEELGILCDGNEKELKRVSLRKQNTILEQKMLQLEVNRKRELLHKKEDSVQSLEKRKLELQAAMKERDEEIKVFLNLIKKQLKNSEKEKHKLNIELNEKLMKIDQIKLRFEMLALSIGAPEGEAERVQAHCITKAALEKEELKQQKSSLDAEVEKMELETKALENTVKVFNHFNSHLRKSLLKVDESSPEYQEKLQLEEQLKATQKTIRFKKQQIQELQRDLEDMDCSLKRLLQDKQVEKAKIDHKQSIITKLKKEMASMQEKIERATKECSKLTKKIRSHKKTKAETFEEKDIRLVELKEVNKKVNRMLNEAMEDQSDLRGVLEKHFQKAGRLLPPPPSGSTSHRSSASRRSSTSSSIKSLGGLKSASVKVTALDLQLDLPAAFSPTTSPECSSAASSKKSSRSSLPLK
The following text describes a protein:
Function:
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin. Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner.
Domain:
The protein undergoes a significant conformation change upon binding to ubiquitinated substrates. The loop that precedes the active site is in an autoinhibitory conformation in the apoprotein. Ubiquitin binding leads to a conformation change; the loop is stabilized in a catalytically competent conformation with the result that the active site Cys can form the reaction state intermediate.
Sequence:
MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGSGGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLVHRF
The following text describes a protein:
Function:
Catalyzes the electrogenic exchange of aspartate with alanine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNAIGNFLVGTPVFTIFICLALGYLLGKLKIGSFTLGATVGVLIVALLIGQLGVFPRDTLLGDIFFDFFMFAIGYRVGPSFISSMKKFGAKIVYATLIFLVSAFIVAYACFKMFHIGPGIAAGIIAGGLTQSAVIGSSLETISKLPISDHLKTLYSNQIPIVYTLTYVFGTIGVLIFLRDIMPKLMHIDLKKQAVKTAKELDMIPVPVIVASTHFYTINDGSSLIGQTLGTVNTKFAKGLVAAGLNDSADMASVINAGDVLAISGGIDEIGRAVQEFNLLEVTGKTKAYVSKQVVLKKNFSADVLKNAQDKGVLVATLAGDVMDPAQFSTLKPAESVTLVGQKDAVSEVQSQLGRLRAAENIINYSWFALGIALSAALGIVGTKVSGVPIALGGGTASLIVGLVQSIYRDKHAHMDTIPDSLLEFFQSIGLNLFIATVGLSAAKTFISAIQSMGISVLLIGAVISILPHIITFVICYYLMKMEPISIIGAQTGADTLSAALNDVSERVGSDASPFFAAAVAPAYAIGNIFLTLMGPIFIVLLS
The following text describes a protein:
Function:
Non-essential cell division protein that could be required for efficient cell constriction.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Localizes at the septal ring.
Domain:
The SPOR domain binds septal peptidoglycans and is required to target DedD to the septal ring.
Sequence:
MASKFQNRLVGTIVLVALGVIVLPGLLDGQKKHYQDEFAAIPLVPKPGDRDEPDMMPAATQALPTQPPEGAAEEVRAGDAAAPSLDPSRMASNNVELDPIPVETPKPKPVEKPKPQPKPQQPVVAASTPTPAPQPVADDKPAPTGKAYVVQLGALKNADKVNEIVGKLRSAGFRVYTSPSTPVQGKITRILVGPDASKDKMKGSLGELKQISGLSGVVMGYSPN
The following text describes a protein:
Function:
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi.
Subcellular Localization:
Autolysosome membrane; Multi-pass membrane protein. Cytoplasm, cytosol. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAEEGNKLTLRRLEAPIHKFIKVALPTDLERLQKHHSNILKYQHSQQWDRLHQEHINASRTVQQLRANIREMEQLCGRVRAEDAAALDVLVRPVRDRASAAARDFLLLHSDSSPTLTTRQPGCASSNCHSVNDEGDKAESGRQSQLHLPEIPADQNAAESWDNLEGDLKELSSLVTEFSLLVHSQQEKIDSIEDNINTASTNVEEGTKSLGKAVGYKLAVLPVAGALLGGVLGGPLGLLAGFKVAGVAAALGGGALGFAGGNLVQKNRRAQVDKQMKQVTEPPHEGQQGVDE
The following text describes a protein:
Function:
Extracellular zinc metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MKKQVISSALALTVIAGGFGAFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKETVFQYLESKKDMFKLAGNIEKHFNIVGEEKDAESDTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLDDKNIPAAASITAEQAETIAKADIEKEIGKVKSYDGVKKDLFVYEKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDNITGFGYGVLGARQSFEIAQDTKTGQFNLFDGKRGQGVHTFDAENMDENWFNLFSQWLGYTGEEVESKSKFFEDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISTVHVGESWNNAAWNGVQMMYGDGDGKTFIPLSAGLDVIGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKSWDLGADIYTPDKPGDALRSLKDPASIPNPLKPSEGYPDHYSKRYTGTADNGGVHINSSINNKAAYLVSEGGDHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKNSKAVQAVTKAYDAVGVK
The following text describes a protein:
Function:
Inhibits papain and cathepsin B (very poorly).
Sequence:
GFTDITGAQNSIDIENLARFAVDEHNKKENAVLEFVRVKSAKKQVVSG
The following text describes a protein:
Function:
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis.
Subcellular Localization:
Nucleus. Chromosome. Note=localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S).
Domain:
A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
Sequence:
MATDMSQGELIHPKALPLIVGAQLIHADKLGEKAEDTTMPIRRAVNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEQENETPPATSSEAEQPKGEPESGEKEENNNKSAEEPKKDEKDQSKEKEKKVKKTIPAWATLSASQLARAQRQTPMASSPRPKMDAILTEAIKACFQKTGASVVAIRKYIIHKYPSLGLERRGYLLKQALKRELNRGVIRQVKGKGASGSFVVVQKSKPPQKSKNRKKGSALDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGANSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLSFPYYPSPGVLFPKKESGGSDDEDEDDDDDESSEDSEDEEPPPKRSLQKKTPAKSQGKTASMKQRGSKPARKVPAAQRGKVRPLPKKAPPKAKTPARKARPSPSVIKKPSGSSSRKPIASARKEAKLPGKGKSAMKKSFKTKK
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the nitrogen fixation genes.
Sequence:
MALTQRLEFRQSQSLVMSPQLMQAIKLLQLSNLDLMTFVEEELECNPLLERASDDAAGAEAPTEVDQVSGDQLAEAQVRDARDGAMTTYTEWGGGGSGDEDYNLEAFVASETTLSDHLAEQLSVAFTAPAQRMIGQYLIDLVDEAGYLPPDLGQAAERLGATQEDVEHVLAVLQEFDPPGVCARNLRECLAIQLRELDRYDPAMQALVEHLDLLAKRDIASLRKLCGVDDEDIADMIDELRRLSPKPGMKFGSARLQTMVPDVYVRPAPDGGWHVELNSDTLPRVLVNQTYYSKLSKKIGKDVDKSYFNDALQNATWLVRALDQRARTILKVATEIVRQQDGFFTLGVAHLRPLNLKAVAEAIQMHESTVSRVTANKYMATNRGTFELKYFFTASIPSADGGEAHSAEAVRHRIKQLIESEEPSAVLSDDAIVERLRVSGIDIARRTVAKYREAMRIRSSVQRRRDNMWSTMNSRASGGTGLDK
The following text describes a protein:
Function:
Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide.
Subcellular Localization:
Cytoplasm.
Sequence:
MTIHKKGQAHWEGDIKRGKGTVSTESGVLNQQPYGFNTRFEGAQGTNPEELIGAAHAACFSMALSLMLGEAGFTPTSIDTTADVSLDKVEAGFAITKIALQSKVAVADIDASTFDQIIQKAKAGCPVSQVLNAEITLDYQLNA
The following text describes a protein:
Function:
Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Colocalizes with actin at the leading edge of polarized cells.
Sequence:
MPVSTALHQDGSQERPRSLVSTTSSSGSSRDSHSAMEEPTGSEASAQNGTGSPWDRHVPNSNNNSSGWLNMKGPLSPFNGRAGTSPAYHKLSYLGRVVREIVETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIESIYALNSQLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMQDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRVLKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEATFRVHRVRNDRTFFLFDKILLITKKRGDHFVYKGHIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRSWTHHIKRLILENHHATIPQKAKEAILEMDSYYPSRYRCSPERMKKAWSSQDEVSSHVRQGRRQSEPGHTLFSRATLPSRQQGFEMPGLKGRRKSEPTRHLLRQLSEKARAVGMKHAGSAGALLDFGQPAHAQKQQPEAERAAREELEEEEELVEEEEQRQQSFSGSLEGLAGHDGSEKVPGPELPGSEEEEEEEESLAVAEQGKRHRESEGSKGCRRPSNRSPTSAEKRMSFESVSSLPEVETDPEPGAEQEAFAALEGPSTEEMPSDPEFPEALETQLHAPKGLLGVDNPAAVVDFVEPEGSEDLKPLSSEEEEEEEMEAAQEPESLLPPSVLDQASVIAERFASSFSRRSSLAIEDGKSSGLGTPRLISRSSSVLSLEGSDKGLARWSSIGDSLSNPPTPEVIIGADMVTDNGPSVNGTESPSAGSGCPTEQDRSSCKKKESALSTRDRQLLDKIKNYYENAEHHDAGFSIRRRESLSYIPKGLVRSSVSRFNSLPKPDSEPAAPVGYKRPGSSRPASWTLFDLPGPRTDKGDPAPITDAEFCPSSEIAKIWERMESSERSPRTGSGQSQANGFELQEPLFILEEHELGAITEESAVASPESASPTEQPSPAHLARELKELVKELSSSVQGELVTPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKNIKAARPPLQWEKVTPDQEEQVPSISGLPEEAGELSGGKARRKPVLSLLSYEQLVAQEHGTSKSSAAVETSPRRFSFSPSAVSPRTTSPGARSSARSPLSPFDTETFNWPDVRELCSKYTSHDKTAQVESSWPRSLLVNRSRSLPENIVEPPMSGKADRCCGLNTHRRLGDGEASQPPLPESPPQSQLNGGDALYVTADLTLENNQRVIIMEKGPHPSSTVGLEEDSGKESSSPVALKGQGQGFQASAEYQPKEHGPRDSADTNKQGRVRNLREKFQALNSVG
The following text describes a protein:
Function:
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Subcellular Localization:
Cytoplasm, cytosol. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1, CASP4 or CASP5 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Sequence:
MAAIPVDDCINFVGMKFIDNTLYFVADSDENLETDYFGKLEHKLSILRNLNDQVLFINQGDQPVFEDMPDSDCTDNAPRTEFIIYMYKDSLTRGLAVTISVNYKTMSTLSCENKIISFKEMSPPESINDEGNDIIFFQRSVPGHDDKIQFESSLYKGYFLACEKEKDLFKLILKKKDENGDKSIMFTVQNKN
The following text describes a protein:
Function:
Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.
Sequence:
MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLESFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAACYMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG
The following text describes a protein:
Function:
Plays a continuous role in plant development probably in the structural organization of compartments.
Sequence:
MIHRTTRVTRKCRSLRPPHPPAATLLTAAASPRRETSAAKPPPPTRTPAVAMHARAKYSPAVLPRRTRTRLDRRNAVKRVDYEAGAGASVSVAASWSFSSSVDQQRSTGPGLQPSRSLDLAPGADLRISGSVEGEVDELCRSLGLSGPEDFAIPVAAWEARKSRSNSDLSGGHTAEAAAGPPRQGESAATTEKKTAPPSKKCRVLMVERLSRKRKTVGSQPTDKPFRTEHMRRLEFAFWFKVSTPPRRSGGRRSRIGRSKTHKRWLRRELGITNDVTSLLQRLKSGGGTWKQLMSHNGQKITFPGEADEAPDTATGDIIFVLQQKEHPKFKRKGDDLFYEHTLTLTESLCGFQFVLTHLDNRQLLIKSNPGEVVNPDSFKAINDEGMPMYQRPFMKGKLYIHFSVEFPDSLSLEQCKALEAVLPPKPVSQYTDMELDECEETMPYDVNIEEEMQRRQQ