lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types. Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (By similarity). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage. Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells. Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT. Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P.aeruginosa infection. Mechanistically, specifically recognizes P.aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (By similarity). In eosinophils, induces IL-10 production through the ERK1/2 pathway. Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MDSENCSITENSSSHLERGQKDHGTSIHFEKHHEGSIQVSIPWAVLIVVLITSLIIALIALNVGKYNCPGLYEKLESSDHHVATCKNEWISYKRTCYFFSTTTKSWALAQRSCSEDAATLAVIDSEKDMTFLKRYSGELEHWIGLKNEANQTWKWANGKEFNSWFNLTGSGRCVSVNHKNVTAVDCEANFHWVCSKPSR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTASVDVSVEVLQECMIQEVTLDGQEIYVLPLTMSENLTKMAHKIDFSKDEFDGKSKQLSEAVDEEEEDEEENENERQYPKQTLVQPSLWPWDSVRNKLRSALTELTALQDILTISRDRRYMTLDYVQHDAGEAKSAFLLVARKRAIASSAGFMNTGMERMKKNLEQIMKNKNHDFHYELLKLRKIWRLKKVGGSILGDLSYKSAGSHFWVSGTFEVVKTDSEAADNEPGTSLQHQQQQPMHPIHSPLSNLSNLNVIIPDELSGNAYIRIIIKRVNEKDCSISTFFSQNFLSSSSSSSSTSSEQLSWSKRLELAQNVLFCKELFAQLYQEAMKHQSRIPNMACGNHIVCHLFPDVKLFISLCHTTEQNKSNNGNKPALALSKQHNSVLEHSVYQLLREIHYNNTNFPPPRPVTMPLGFIKKRHHLGPAGSTKSQISDFNLGLPRNIILWPFVSQAKHYFNRQRVINMIDEIVIEVHEPQIIVHTSYLNSATSTGLRLTMAFSGFEHNKTCIMLYIYETKLEVACKDGSFQTLDVDFKQLRRFIMEQVTEHHLLMVSVLAKAFDWKILSMNKNCFPPKDYIVSRDCGYYDDETVKMHHDEELTGDINPSMGMLIISPKQNRMLSIHCFRNNTQIVKVCRKPGVQQASGASVEAVENEVMQGCEDLPPKWQETVDCFEFVYMEYLPGKNFAQKLEVLMAALVPDLTA
The following text describes a protein:
Function:
Might be a 5'-3' DNA helicase.
Miscellaneous:
MISCELLANEOUS: The fourth ligand for the [4Fe-4S] cluster could be Cys-130; Cys-132 or Cys-152.
Sequence:
MEFKGYIKEKFPYPKVREPQKRMMLKIYECIKNKRNLIVEAPTGVGKTLGYLIPALYFAERRKRVLILTETIDQQVRIYEDLSSLRHNLKVAFLMGKSNFICKSKGGKANRLYCQLNKKCLYRPNKRPICYCGTKKQPVNLGDKVIYYCPYCTCEYQKAKIESILADIVVMNNSMFYYAKEDIEAKRDIDIIICDEAHKLESSIRNTSTIIINPELPINRLKYMAIHYAPNILKKRLDIGDENFWEIIEKYLTSRGINIDICKETIIFDGENLSSWKYKTELAVLGAILDAYYQINNIKNKILRFNENEEIDREELRFEIDNKALIAIELDFIHKKKLSDLYLLEFIENIKNLRYINENYVVYRSGNSLLCEPVFVSSHLKELYGNAVVIHCSATIGNLKMHALKTGLDKAEFLILESPFPKNRKKIIALKDGVDMKYERKDREKANKNLLKILEAINGNSLVLFKSFEDLDSFYKYLKREITKTNIKNKNIHVYEQGMDGKEAKELKERFEKIGGILLATGRFAEGVDIPGEALVGVVIDSLPFPVPTPLILREQKILEERFKIRGVRDAHWRAFLMTSFDRMARTLVQMIGRLIRTENDYGVVVIQDKRFADWVGRVMREKGYLKDNYEVMSLDMAIKYIPKFMSQFKN
The following text describes a protein:
Function:
Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (By similarity). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (By similarity). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (By similarity). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Melanosome.
Sequence:
MVADPPRGDSKGLAAAEPTANGGLALASIEDQGEAAGGCCGSRDRVRRCLRANLLVLLTVVAVVVGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVALALALQPGAASAAINASVGAAGSAENAPKKEVLDSFLDLARNIFPSNLVSAAFRSYSTSYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSEQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTEVRSTEPELIQVKSELPLDPLPAPTEEGNPLLRHYRGPAGDATVASEKESVM
The following text describes a protein:
Function:
Transcription factor (By similarity). Plays a role in neuronal signaling in polymodal sensory neuron ASH, downstream of sensory receptor activation. Required for maintenance of AVG synapses.
Subcellular Localization:
Nucleus.
Sequence:
MVADVLRQSVLVPISMYPQYPVPRRYTTSVFKEYQKKKKIYYCQRCLNHDVPRPRKNHKCECPYADCTCEKCGLVEKRRILNIRLQNYNQFNIENENDSKLIIVEDDDKKKQGERVPNCQKCGQHGRKSRLKGHKRSCPFRECPCAKCAVVSERQKLMADQIKIRRRQRKDTLLTFAKNSITSTMFPSNQISLNALNSLLYGSINTSPQPLLSSPTSSDASSCSPSMPFTPSIPMFMPTSADCSPTTQTPTSSIPSSIASTSPLMTSLPLRLSGFPLLNIRDPSAEASLLNLGCNADAAALLKTILDQYRMLEEASMSMSSSPSKDDESGDEDSDGLNSNSIIDVITV
The following text describes a protein:
Function:
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Subcellular Localization:
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Sequence:
MEEFVNPCKIKVIGVGGGGSNAVNRMYEDGIEGVELYAINTDVQHLSTLKVPNKIQIGEKVTRGLGAGAKPEVGEEAALEDIDKIKEILRDTDMVFISAGLGGGTGTGAAPVIAKTAKEMGILTVAVATLPFRFEGPRKMEKALKGLEKLKESSDAYIVIHNDKIKELSNRTLTIKDAFKEVDSVLSKAVRGITSIVVTPAVINVDFADVRTTLEEGGLSIIGMGEGRGDEKADIAVEKAVTSPLLEGNTIEGARRLLVTIWTSEDIPYDIVDEVMERIHSKVHPEAEIIFGAVLEPQEQDFIRVAIVATDFPEEKFQVGEKEVKFKVIKKEEKEEPKEEPKPLSDTTYLEEEEIPAVIRRKNKRLL
The following text describes a protein:
Function:
May modulate activity of the MtrAB system in controlling homeostasis of the cell wall and cell division (By similarity). Partially restores antibiotic resistance to M.smegmatis in which this gene has been disrupted.
Subcellular Localization:
Cell membrane; Lipid-anchor. Secreted, cell wall.
Sequence:
MERLMRLTILLFLGAVLAGCASVPSTSAPQAIGTVERPVPSNLPKPSPGMDPDVLLREFLKATADPANRHLAARQFLTESASNAWDDAGSALLIDHVVFVETRSAEKVSVTMRADILGSLSDVGVFETAEGQLPDPGPIELVKTSDGWRIDRLPNGVFLDWQQFQETYKRNTLYFADPTGKTVVPDPRYVAVSDRDQLATELVSKLLAGPRPEMARTVRNLLAPPLRLRGPVTRADGGKSGIGRGYGGARVDMEKLSTTDPHSRQLLAAQIIWTLARADIRGPYVINADGAPLEDRFAEGWTTSDVAATDPGVADGAAAGLHALVNGSLVAMDAQRVTPVPGAFGRMPEQTAAAVSRSGRQVASVVTLGRGAPDEAASLWVGDLGGEAVQSADGHSLSRPSWSLDDAVWVVVDTNVVLRAIQDPASGQPARIPVDSTAVASRFPGAINDLQLSRDGTRAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDAAHPVSYVNLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGWADVPGLMVPGAAPVLPG
The following text describes a protein:
Function:
Purine nucleoside phosphorylase involved in purine salvage.
Miscellaneous:
MISCELLANEOUS: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASSTTTTAMKIGVIGGTGLDDPEILEGRTEKYVDTPFSKPFDALILGKIKSVDCILLARHGRQHTILPSKVNYQATIWALKEEGCTHVIGTTACGSLREEIQPGDIVIIDQFIDGTTMRPQSLYDGSHCCARGVCHIPMGAKEVLIENAKKLGLCFMFCTWGVDVINMTTVPEVVLTKEAGICYASIAMVTDYDCWKEHEEAVLVDWDLKTPKENASKAKRLLLTTIPQIGSMEWSKTLHGLKNIAQSSVLKFLQSIHLTKD
The following text describes a protein:
Function:
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Required to prevent extensive loss of sequences near G-quadruplex (G4) DNA sites, which are prone to cause genome alterations, by generating deletions.
Subcellular Localization:
Nucleus.
Sequence:
MDEASCRFPEWVSSKIIDYYAEQNIKALFDWQIDVLNEARQFEDQHLIFSAPTSAGKSIVAELLSWKVASTGRKVLFVLPYISVAREKLHQIQRCWRRDDISVCGFIGPQASNPNEWLGAVCTIEKAASLTNRALSEDWFEEIGMIVVDEMHMVFDSSRGAHIEHMLSKVLLWNQSALEKVRIIGMSATIPELYRIGKWLDGAKVFEARFRPIVLQNHIVIGSELRKSGDNKVLREFSEDPLILLTEESFRRNSQTLVMISSKLDAEKTALNIASRFHEINKTDSSLLEILKERANGLLFIKHGLERNGCKDRNVMSTLAWGVAYHHAGLTMEERECIELGFREKNIVILVATSTLASGVNLPAERVLIKAQPRGPSALTSLNYRQMVGRAGRTGHATRGETYLLIKKCDRDAVLKIIETPIDQGVLTRKRDAERTNLSRFILEGICTGLTTTRSQIHDLCKLLLFNSENLQLSDIAIEMLLRNSFISQDENDDQLSPTQLGRAAIASSLPPEASLAIFEDLNSASRAIALDTELHMLYLVTPINVSVWQECDWHHLFSIFSKLPSDHKRIAKLVGVSEKFILDQLQGRRNDKLLQIHIRFFSALALFDLISEMSIYEVSHKYRIPRGCLQTLQSQSATYAAMIVAFCLRLGWTYLKALLDGFATRLLFGVRSELSELVAIEGIDGQRARILHERGVTCLSHLSACDSSKLAHFLTLAVPYSSSNSNDGLGEWLFGEPRMRVDVAARTLKERARKVLIRRVQELGISVELPKFEENEENIQESCDSGLPDSCEGMEDELEEKENIVKMEEMTKSVTEMSLTDNTISFKSEDDLFKKEIKVEEDEVFIKKEIDEDEEEIVEETVIECLETSLLKLKASTDEVFLRRLSQTFSPIGRSRSILNNSLLEDSFDRPVPRSSIPILNFITPKRESPTPYFEDSFDRPIPGSLPISSSRRKSVLTNIANLDSSRRESINSNASDNNSFDVFVTPPTKSAKEEKRRIAVKHPRVGNIIYSPLTSSPVIKHPKLEINHFYLKDVCHDHNAWNLWTKSSTSTSSCSIRVSDDYTGIAIRTDAGNTFIPLLETFGGEPSPASKYFESFSKCIIPLNTRLEFLKTLAVTVEMYISSMEDAFLIFEKFGIKIFRLKVVRIAAYLNNVIDVEQEENSNFLPILMDRYSILDPEIRKTCSSSLHKAAVEVYSLKPIFEKMCCSGASLQLEMESCQTVLNIFYSGIVFDQALCNSFIYKIRKQIENLEENIWRLAYGKFNIHSSNEVANVLFYRLGLIYPETSGCKPKLRHLPTNKLILEQMNTQHPIVGKILEYRQIQHTLTQCLMPLAKFIGRIHCWFEMCTSTGRILTSVPNLQNVPKRISSDGMSARQLFIANSENLLIGADYKQLELRVLAHLSNDSNLVNLITSDRDLFEELSIQWNFPRDAVKQLCYGLIYGMGAKSLSELTRMSIEDAEKMLKAFFAMFPGVRSYINETKEKVCKEEPISTIIGRRTIIKASGIGEERARIERVAVNYTIQGSASEIFKTAIVDIESKIKEFGAQIVLTIHDEVLVECPEIHVAAASESIENCMQNALSHLLRVPMRVSMKTGRSWADLK
The following text describes a protein:
Function:
Transcription repressor that regulates phase transition during shoot, flower and seeds development. Controls leaves development, shoot architecture and flowering by delaying both the vegetative to reproductive transition and flower initiation. Participates in polycomb group (PcG) protein complex-mediated (including EMF2) silencing of the flower homeotic genes AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3), as well as of some regulatory genes such as ABSCISIC ACID INSENSITIVE3 (ABI3), LONG VEGETATIVE PHASE1 (LOV1), and FLOWERING LOCUS C (FLC) during vegetative development. Required for histone methylation or for maintaining a stable histone methylation (e.g. H3K27me3) pattern of repressed target genes (including genes involved in salt stress response and flower development); this repression is counteracted by ULT1. Can bind non specifically DNA (both double- and single-stranded) and RNA.
Subcellular Localization:
Nucleus. Note=Follow a speckle-like pattern.
Sequence:
MGSSIKINSISIDLAGAANEIDMVKCDHFSMRGFVAETRERDLRKCWPFSEESVSLVDQQSYTLPTLSVPKFRWWHCMSCIKDIDAHGPKDCGLHSNSKAIGNSSVIESKSKFNSLTIIDHEKEKKTDIADNAIEEKVGVNCENDDQTATTFLKKARGRPMGASNVRSKSRKLVSPEQVGNNRSKEKLNKPSMDISSWKEKQNVDQAVTTFGSSEIAGVVEDTPPKATKNHKGIRGLMECDNGSSESINLAMSGLQRRKSRKVRLLSELLGNTKTSGGSNIRKEESALKKESVRGRKRKLLPENNYVSRILSTMGATSENASKSCDSDQGNSESTDSGFDRTPFKGKQRNRRFQVVDEFVPSLPCETSQEGIKEHDADPSKRSTPAHSLFTGNDSVPCPPGTQRTERKLSLPKKKTKKPVIDNGKSTVISFSNGIDGSQVNSHTGPSMNTVSQTRDLLNGKRVGGLFDNRLASDGYFRKYLSQVNDKPITSLHLQDNDYVRSRDAEPNCLRDFSSSSKSSSGGWLRTGVDIVDFRNNNHNTNRSSFSNLKLRYPPSSTEVADLSRVLQKDASGADRKGKTVMVQEHHGAPRSQSHDRKETTTEEQNNDDIPMEIVELMAKNQYERCLPDKEEDVSNKQPSQETAHKSKNALLIDLNETYDNGISLEDNNTSRPPKPCSSNARREEHFPMGRQQNSHDFFPISQPYVPSPFGIFPPTQENRASSIRFSGHNCQWLGNLPTVGNQNPSPSSFRVLRACDTCQSVPNQYREASHPIWPSSMIPPQSQYKPVSLNINQSTNPGTLSQASNNENTWNLNFVAANGKQKCGPNPEFSFGCKHAAGVSSSSSRPIDNFSSESSIPALHLLSLLDPRLRSTTPADQHGNTKFTKRHFPPANQSKEFIELQTGDSSKSAYSTKQIPFDLYSKRFTQEPSRKSFPITPPIGTSSLSFQNASWSPHHQEKKTKRKDTFAPVYNTHEKPVFASSNDQAKFQLLGASNSMMLPLKFHMTDKEKKQKRKAESCNNNASAGPVKNSSGPIVCSVNRNPADFTIPEPGNVYMLTGEHLKVRKRTTFKKKPAVCKQDAMKQTKKPVCPPTQNA
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome.
Sequence:
MEQGARGRYWRRLVLPGVLWATAHLSPRGAASPLRFSRDTENNTQCIFAPSSEFPEGFFTKQEQTDGGIIIYFLIILYMFMAISIVCDEYFLPSLEVISECLGMSQDVAGATFMAAGSSAPELVTAFLGVFVTKGDIGISTILGSAIYNLLGICAACGLLSNVVSKLSCWPMFRDCVAYAISIAAVFGIIFDNQVYWYEGAVLILIYGVYVLVLCFDIKINQYIMKKCSPCCTCLAKAIEGQAEEPLMGWEDRPLIRRQSRTDSGIFHEDSDYSQLSTSLQGFNEVSEDPPSVFSMPEADLKRIFWVLTLPIITLLFLTIPDCRRKFWKNCFMITFFMAAVWISAFTYVLVWMVTITGETLDIPDTVMGLTLLAAGTSIPDTVASVLVARKGRGDMAMSNIVGSNVFDMLCLGAPWFIQTAFTNTSAPVKVNSSGLTYTAISLILSVVFLFLAIHLNGWMLDKKLGVVCLVIYLVLATLSVLYELGIIGNNKIRGCGD
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MRREISFLLQPRCLLLLVALTIFLVFALFNTGKDEEKQVIEDHEITNRVFLDVDIDGQRLGRIVIGLYGTVVPKTVENFRALCTGEKGKTSSGKPLHYKGTPFHRIISGFVIQGGDIIHGDGKSSDSIYGGTFPDENFKIQHSHAGMVAMANTGPDSNGSQFFITTVKASWLEGEHVVLGKVIQGMDNVFAIEGGAGTYSGKPRKKVVIADSGEIPKDKWDEER
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane; Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVTSIRVIVGIIGSVVCVLLYAVPVLTFKRVVKEASVGEFSCVPYILALFSAFTWGWYGFPIVSDGWENLSLFGTCAVGVLFEASFVVVYVWFAPRDKKNIICRPAFNLQKSVVLMVSLVVATLCVIVSLSSFVFHTHHMRKQFVGSIGIVTSISMYSAPLVAVKQVILTKSVEFMPFYLSLFSLLTSFTWMLYGILGRDPYLTAPNGAGCLTGLLQIAVYCIYSRCNRPPKAVNGATTSREDANDCKV
The following text describes a protein:
Function:
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Sequence:
ENMTFGTTLVTNPKGGFLACGPLYAYKCGRLHYTTGVCSNVSSTFETVKAVAPSVQECKTQLDIVIVLDGSNSIYPWESVTAFLNSLLRNMDIGPQQTQVGIVQYGQTVVHEFYLNTYSTTEEVMDAALRIRQRGGTQTMTALGIDTAREEAFTEAHGARRGVQKVMVIVTDGESHDNYRLQEVIDKCEDENIQRFAIAILGSYSRGNLSTEKFVEEIKSIASKPTEKHFFNVSDELALVTIVEALGERIFALEATTDQQAASFEMEMSQAGFSAHYSQDWVMLG
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MAAGEILRQLSLLGENDNNEEPNPENRYFINNKFSQLFLLTSLVDYPAVWPTFFHDLLAALNLNNISRISHQVVNMYLRILLMLHEEVVDRDIPHTDMELRRNGLFKDCMREQCVTDLVSSWFDILVLYESLLSTSPSISSTILASCLQTIGSFVSWIDINLIANDRFIEIILRLMGCNKVVGSSQLVVPPIVRGAACSCLSEVISKGMDSVMKLKLVESMVVILETSGVIRDVVDLLDKNENTKKALVKSEDDDGDDEEEEDDDDEYLEKFAHLMANFGQQLVLCWQKFVKNKDLENAKIALDALQPKLGLLLKLFGNDDDDVSRTTINFLTDYIGLLKMLPSSSEVSSFVEQVLCVLLKKMRYMKGYNFNHEGEEECDFQEYRKELKIVFVNLSSLDCDVLLKYVASNFNVVMSSLQQTTSFEDVEVAIYSLFLLVEVMPTSNTGGRTSKVPEQRINILYEMIKTLIISQVSHYPHPAVQSQFFETIARYDRFFSAFPQYIHRVLEAFLDERGIWSAHCHIRSRTAYLFSRFVKSINKAHLQDSLEMILTRLESLLVLNTSLPPLPPPHLSSSSSQHKTSHHHHNSSHNHHPHPTSSTSTFHHGGMMKHNFDANNMCNSAAVKMNNGGGVGTSNAAAVDNSNLQLSTDDQQFMFETASVLIVQSSFAPERKRELLNRLVVPILLQFEELLAQMTSERDESLQVFYAQLLNRAMSFISRTSKGFSGQQTVHGNGCISTYTGAMQVFIKVLQVPIQTHLLHQGFRQFLHRMVICMDTDILQFIPTSVEGLMLNASIKQLHEFIPFLNQLIQKFKKTIVPYMQKVFIPIISLIQKSLTSAAVDEEDQVIQMEKKMLQRGYYGYINVIINNDTAEILSNQEPNDLNIILTTIIQGAANCSDPTAQKTCFAILKRMIEIWGGTNIVPNLREFVYKEIVPCCFQVPLSNEFDVVDAQTILVLNEIAGCLGKAHRTIGPELINYVTFTYLPSLNFNNQVIQEFCQNLAQSNDKIFQNYLKSFVLQVRQAES
The following text describes a protein:
Function:
May have a role in germline development.
Subcellular Localization:
Nucleus.
Sequence:
MNSSNDLSDELIRRLSVGGALEEVIASEMFEDSIDVETEAEPDDIIIVHMDIREPLSMLKSLVEQKIGVCLNYYTFWLQDAQELESHKNLVDQCVKGEGLVQINVQIQTIRKRINIADVLKPTEAALAALAEEVVGQLSPPETASQKSSSSESPIKTPLKRMHKEDSEEESVEGKDVKPVLNWVLDSKFKREQIRLKIPEAANEWTHAHVTYWLEWAVKQFELVGINMSDWQMNGQELCAMTHEEFNQKLPRDPGNIFWTHLQLLKECNFVSVVHKRAEEQRKPKQPRIMSANSISTNSGGSLSLEQRIMRKSYQSVKSSDSVESTTSSMNPSNYTTIGSGNNGQVQLWQFLLEILTDCEHTDVIEWVGTEGEFKLTDPDRVARLWGEKKNKPAMNYEKLSRALRYYYDGDMISKVSGKRFAYKFDCDLKLLIGYDANELSTLVSEGKTAPERVAATETITEDT
The following text describes a protein:
Function:
Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. Clock (Clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner.
Subcellular Localization:
[Corazonin]: Secreted; [Corazonin precursor-related peptide]: Secreted.
Sequence:
MLRLLLLPLFLFTLSMCMGQTFQYSRGWTNGKRSFNAASPLLANGHLHRASELGLTDLYDLQDWSSDRRLERCLSQLQRSLIARNCVPGSDFNANRVDPDPENSAHPRLSNSNGENVLYSSANIPNRHRQSNELLEELSAAGGASAEPNVFGKH
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MAMTTNGLSSKLIRNIIRRVNTPSPTTTLTTPRFRSAQRTTINTTSTTILQPPSPPPVNAAGAVTDDARDTIFDFDDTKGLFSSVSTGKLLRSAANLNLAAVEPVVDLGMWVMRSRVMHVGLLREIVLGVIKHTSYEHFVAGADLEETGRTVQKLWESGLRGMLDYGLEHAVDNQSCDTNALQFVKTVESTQSLPPSSVSFVVVKITAICPISLLKRVSDLLRWEYKNPTSTNLPWKLKTLAIFSESSPFYHTLQKPSPLTPEEEHDLELAHQRLVNICNKSIECNVPVVIDAEDTSIQPGIDYFTYSASVMYNKGQKPLIFGTIQAYLKDAGERLFETKKAADKMGLPVGFKLVRGAYMWSESKLADSLGVESPIHNSIGDTHNCYNKCAEFVLDEVSNGPGGLILATHNLESAKLAAQKARDLGIGKDSEKLEFASLYGMSEAMTFGLRNAGFGVSKYLPFGPVDQIMPYLLRRAEENKGLLSSSNLDRQLMMKELKRRMKAYVGQGLEETENQFKSQAGSVVKLN
The following text describes a protein:
Function:
Involved in cell cycle progression and surviving DNA damage.
Subcellular Localization:
Vacuole membrane; Single-pass membrane protein.
Sequence:
MGNVSVAVGTAVGIPIAVGVIIALIFWCKLQRRYKKEEIRDADLEKMVMEEVAVSVYDGFKAEINSSSEASTINEKEANQDLKPCQEKTAKAGYTPAYRRQLNASMGTLRPKKQSTAYTNVPVIFSGEKVNYGMVRDPSYSFMYPLTLSRKETSSLRSASTSNLSSSTENTALHEEIKLDDPYENDFTNYTVNKREFIDSLRPH
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.
Sequence:
MARYIDDRPYNITQHQLQLAEEIAFDRKNWVFPIQTHENKVACITKDDIGTNIDTLTDALHGIDAMYTYDSNVLLTMCYADCVPVYFYSTKHHFIALAHAGWRGTYTEIVKEVLKHVNFDLKDLHVVIGPSTSSSYEINDDIKNKFETLPIDSANYIETRGRDRHGIDLKKANAALLIYYGVPKENIYTTAYATSEHLELFFSYRLEKGQTGRMLAFIGQQ
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MRLLVAGRHMSRSPTVARLLASQASPPASGQPPPSPSSPSSPPSPPTTFAPVNAALAKEIEDKFAALDPTFRNTKEAFKSKSNLDLIRALVVLKMCAIKPLVQHNQAILATMRRILGKNLFKKALKNSFYGHFVAGETTEEVGHTIERLKRFGVKSILDYSVESDLSHDEAEQKTNATSSMEAEVSPPAIVDTGVVDSATVDLTHERYSAHKDFADRRVNVHAARTYIYEGEKACDVNRDVFCESIDAVAKASGGEGFAAIKITALGRPALLLRLSESIAQTHNFFKNFGVKIDKDITEQWFETVDFDRDGLVDFHGWDQLLEDNQKLGQMFKVLNIKTGKLEPLIQNLTPQEEQEFTNMIQRTVEVAEYGIARGIRLMVDAEQTYFQPAISRMAVAMMKKYNKDRGNIFNTYQAYLRNALDDMECDMQKARREGWHFGAKLVRGAYMDQERARAAAIGYEDPINENYEATGRQYERCLTRIADELARRGRGNVSVMIASHNEDTVRFATKLMRDRGIAPSERIMCFAQLYGMCDQVSFSLGQAGYSVYKYLPYGPVEDVLPYLSRRALENGSVLEKAKVERGMLSSELRRRISNGQFSYKP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAGISMQTFVTFDDVAAYFSEDDWQCLEEWQKELYQNAVQEIHGVLLAMGYTISNPEVLVRIQNLETSHFSENPDLTKSKNCCNFTHGFPSHHPDILLRVKQQAQTLLSDQLELQEKSCRTSSVDENNSPLASTHKESTGSSKLAGDRLAGDYLEDDNNEDQLPEKVKENILCWEDIFEKNEPKSIPKEGPNESERDEGLACTNPVKMDQKPSVPKERLYICSVCGKSFGGNSLLVRHMRIHTGEKPFACNHCDKSFNDKSYLLRHLRTHTGEKPYSCSVCLKCFSQNSSVIAHMRIHTGERPFQCPECEKRFSDKSYFVRHMRTHSGEKPYKCSHCEKCFSQTSSLTSHMRIHTGEKPYKCSDCGKCFSQNSSLALHKRLHKPE
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIYFIFAYFCLATLGISIMSLTRKNPVHAVLWLLLLFLHVAVIYLFLNAEFLAMVQVIVYAGAILVMFLFTLFLLGARQLPKHKRYTSILEGRLLIGLSITATLLAVFSSIKAEYSGKYTIKYVHDVGNTKAIGAMLFNEYSLAVLILGVILLIPMIAVSVLAWRRKDDTS
The following text describes a protein:
Function:
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGQCTATVAKRGNMKFSVAIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKEVKRAQKQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLYPGEDFLPPMVCVGCPKPIPVDSPDLEEALNHSIAKLNAEHDGTFYFKIDTVKKATVQVVGGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWEEKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGKEQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHRSHGLGHGHQKQHGLGHGHKHGHGHGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDFQDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVNGVNPTVEMKESHDFDLVDALL