lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAVLSKSEVEERIANGEVIVIYKSAVLKLDKWIKYHPGGDKAIYHMVGRDATDEMNAYHSDESVQQFMRWKIGHVEGEWKNLVPPIQRNACETSMQPGTPGDEDTCYEDDACDAKVETMGQAYKNHVVVDPMQLSELFDEERAALDRKLFPSADSETQQRISAEYNKLHQELIDAGFYACPYWKYGVELLRISTLLGASYFTLIRLNWQIVSALLLGVAWQQAVFIAHDAGHISITHNYQVDSVFGMLVSAWFGGLSLGWWKRNHNVHHLVTNDPEHDPDIQHLPFFAVTSRLFTGLKSTYYERDLAFDLPARIFIPLQHILYYPILAFGRFNLYVLSWTHLLGGKGPRHGQAAWFRYFELCGLVFFCYWFCYRLLACSLSTATDRVLYVLVSHLTTMIVHVQITLSHFAMSTADLGVSESFPQRQLRTSMDVACPRWLDFFHGGLQFQVIHHLFPRLPRHNLRDAQPYLLRFCERVGIKYSIYGFSHCNSMVLSHLEQIAQQARTVLACAHTMGPHKDVAMPAPGGDSRQYSNPKHA
The following text describes a protein:
Function:
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
Sequence:
MNFLEDLFYPLRLLENKRVLLLVSGSIAAYKSLELVRLLFKSGASIQVVMSKGAKKFIKPLSFEALSHHKVLHDRNEKWYYNHQNALHHNHIACAANADLLIFAPLSTNSLSKIAHALADNIVSATFLACASPKILAPSMNTNMLNSPITQSNLKRLKDSNHIILDTKNALLACDTKGDGAMAEPLEILFKAAQTLLKDAYFENREVIVMGGASIEKIDSVRTISNLSSGIQASALALALYFKGAKVTLIASNFPTPLPKEITSVLVSDTASYENALNSAANNLQKHALKPLLFNLAAISDYVPKTSFNYKLKKSEIGETLNIECVQNKDLLVSINPNQFVKIGFKAEDNQQNAIKNAQNLLKPFKDNGKDCSVVALNLIKDSRPFGSLENELWLFSHHKTQKIPSMNKLEASFKILDFIKDNAL
The following text describes a protein:
Function:
Folate transporter with broad substrate specificity. Transports folic acid, folinic acid, pteroic acid, dihydropteroic acid, the folate precursor p-amino benzoic acid (pABA) and the human folate catabolite pABA monoglutamate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=In intraerythrocytic stage parasites, localizes to the plasma membrane and some intracellular vesicular structures.
Sequence:
MEDDDFSIKDKKENYETCSTETISSYISINEKCQLIEKDINDDNHENPYMIFNKISSSLIAMLQGVEVLCNLSIIYLLKDNYHLHPASLSIVMCFIKIPWSIKLVWAVISDNYPIFGYRRKYYLLLGSFLCILSLICLGLITHNNLFITILLLFIYFFGSSLCNVIGEAQVVESNRNCSINSSARNVSLFFAFRKLSFAIMSYLSGYLLLLISKKHIFLIGSFLPICVFTSGFFIIEKRNYTKSSIKDQIKCIYSIIKLSYLKNFIIFIFIMMSTPSCGNTLFFYITNELKFSPNLLGKMAMFQSLASFISIISYMLFFTKIDIRKLLLYSTIIITPFCLLPLVVIKKVNYFLFIPNTLFFITDTVLIEFIAEFQTMPILVLCSRLIPEGFESTIYSLLLSSNNFASIISSFLSSLLTYSLNITSTNFTNLPYMIIICCLTNIIPIFFLYILPNHSQKKNLQHSNSHTQKYYSYPSTDYISSQKSDSSEITKFSADMQIDDITLE
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MQEKEYCVSGFNWGRIDIDKNSVQLTHDGYLIFKMNPKDFTKSSISNKTEVSIEFDDSKDGDALSEIKFFAPQTEQQNDKDNATELYDKIAEVTPTNAAGKEVCLFENIGFLSPKGHYDVKIYEDSVRVQNKTYDFKINYKDIARYYKLRKDEDTSFFILNLSNPLKKGKSVYECLVMELSSNEEVTAELHLTKEFEDKTGLEESMTDNELDLFVELFRSLCNVPIISSGHKFKTNDSHFLKCNLSTNEGFLFPMSDSFIFVFKRIRIIMFKDIKSVDILRMNASNDNKTFDFVINLKGRRGSLQFTGMNRNEYENLVGYLKESQLKLEETLQNTERRMEEDDDSGDNDEEYHAEEEESGDDDIMSESEEEEEEQQ
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MASKLLRKLAYPTLPVKGKIYDPFSKFQQNLYGGSKTEAGNNKIPKFGHKTRRVWIPNGHSKWLYSNVLEEKFHLYVTSRVLRTIDKEGGLDEYLVKSTPSRLKSLGLRGVELRALVLHKLGAKNPILEKLPSDSGAQKRYLEKVKDVVLKLNRSKKLYQQIKSLVGKERSVNTSV
The following text describes a protein:
Function:
Velvet-domain-containing protein that acts as a positive regulator of sexual development. Positively regulates the production of the sexual fruiting bodies called cleistothecia.
Subcellular Localization:
Nucleus.
Sequence:
MTTHVGPQTTLLHQTGQISALIAGEAVQTCEASSCQMSGTPFQQWTYVTEGRYTNARTHPSDEDRRRQTTVSNPRYLAQEPPRFLLPTAQNNAPTMSQSATYSTLPVQGFPEQNRVLDNRSDPKYGPLPATTGSLAQYSIQRPSTSRNMENAGSSSSYYDAPSCSRGSVGSIGRMNDLDSQYSGSTTAFPSPVHSDSSPIYPAIAPISGYQQQLPIHQRHTTSSMPSGFENLLHHHSTSPSPPPRCASSSSRYRLFIRQQPLAARACGAGDRDRRPVDPPPIIQLLLTEFNPNSEKDRSILQDPRFTVGCLLYPVRNPSYLPGSGSGAGSSDTNTNSNDKSRHESMSSYSQLGINLEDSHATGQSTPLLSGKAFVSPFFVDEEPDPNTAPAHPSSTDDSTYDASPRTVTHRFRNRPLPKPPACFFIFSDLSVRTAGLYRLQFRLMNWGSIEDTGQSMPILAEVWSEPFRVCAAKDFPGMRDSSLLTLRLKELGFVELKTRGQGMGKGRRVGIGSSKVSSRARVE
The following text describes a protein:
Function:
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Might promote cleavage furrow stability during cytokinesis. Not required for chromosome segregation during meiosis.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Requires knl-2 and lin-53 for chromatin localization. Co-localizes with hcp-6 at prophase, metaphase, and anaphase chromosomes.
Sequence:
MADDTPIIEEIAEQNESVTRIMQRLKHDMQRVTSVPGFNTSAAGVNDLIDILNQYKKELEDDAANDYTEAHIHKIRLVTGKRNQYVLKLKQAEDEYHARKEQARRRASSMDFTVGRNSTNLVDYSHGRHHMPSYRRHDSSDEENYSMDGTNGDGNRAGPSNPDRGNRTGPSSSDRVRMRAGRNRVTKTRRYRPGQKALEEIRKYQKTEDLLIQKAPFARLVREIMQTSTPFGADCRIRSDAISALQEAAEAFLVEMFEGSSLISTHAKRVTLMTTDIQLYRRLCLRHL
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MADLQDLFNSPPRPPPPRSVHSLSPSTPARATRPNQTPLFFSPGLSPGYEPGGRETSGIGAGARDISIFGRSPSPAAGPQVIRVEEQREQDATNGIVRIRQAVNVLPADGSAFGEGGAGTFPVGTAGATGGGRGGEWNNGVFVNNSVIHDPLAGLGGDDDEDNEEGDGIGRKRVIAKVDADRLLGENGIPALCRAAKKFKPRGKGREADDLRRVLNMYQMWAHGMFPKGDFAHTMHRTETVCRSRRMESALSGFKDAFNPRPPTLPREFSNSPQASPSRSGSPSRARSTSPDSNPNPFRVPTYATTAHPNMREPLFNPADPEDEPNDGPDMEDLLAMEAEMAMEAEAAAEAERAEAEAGARTEAGGHGAEIGATEGEEDEFGGLYD
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MPKGRAAQSKKPTVKIESEPEYTSDEDVTPHIGHSASQLSEYEKRRLENIRKNNEMLAKLNIDVVKQELVSSATKKRKLNNLSIKKTQSSVELPRRKSLRIRRITPDGMALPEPPPTPVYPEPSRLPSGPLDMDPINEVEDIEAKGFLCKMNQLACKVKKTPVKSSSKELKSLSLHEKSLRKLQVKEDHVHKVVSKRIVSILFHPAQTKVVVLASDKSGKLGMWDVGSSSSSEGVYLFEPHSNVIPSLAFDPDDTTKLYSCSYDGTLRCADLTVPVFHEVDLKFTLLFNTKKVLSLVEDDTAFSYMTFGTTSHSCLLASCFDGSIMIVDSRIDAKKRNPAQTLDVHDRAIKCVDVHPTNRNLVCTSTRNGAIAFWDVRNFKNRKSILSSLQLGRSVSSAFFSPITGQQIVATCMNDTVTVHDVSDSGIATHRPKCLFRHDNGTGRWLTTFNAVWDPKHDDLIAVGSMSRNRQIDVYSSDYPNSQLLSLQHENMTTINSRLAFHPSLNMLVGGNSSGKVYLWTE
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase.
Subcellular Localization:
Nucleus.
Sequence:
MARNKEALVLLLDVGPSMHHLLPEVEKICSMIVQKKLVYSKYDEVGVVLFGTEETENELTMEVGGYEHVVVLQNIKVVDGDLVETLKQIPRGTVPGDFLDAIVVGMDMLIKKYSSTNKGKKRLCLMTNGLSPIKDPYEGSKEDQVNAIAEQMTSHGMKLECVVVRESVVRGENVSVMEENDRILNLFPQKSCAKTIFVESSTSLLGALKTRNISPVTIFRGDLEISPKLKIKVWVYKKTSEEKFPTLKKYSDKAPSTDKFASHEVKVDYEYKSVEDANKVVPPEQRIKGYRYGPQVVPISADEWDAVKFKPEKSVKLLGFTDSSNIMRHHYMKDVNIFIADPGDQNAIVAVSALARAMKEMHKVAILRCVWRQGQGNVVVGVLTPNVSDNDHVPDSFYFNILPFAEDVREFQFPSFSNLPASLLPDEEQQEAADNFVKMLDLTPSDRKEMLQPDFTPNPVLERFYNYLELKSKHPDAAVPPLDKTLKRITEPDPELLAQKKSAIDSLLRHFEVKEKPKLKKSTRRMREKPSGSDDEDNYRRISSKTEVELIENGGKVEKIGDLTPVQDFEAMMSRRDNPEWVNRAITEMKNKIHDLIEDSYEGDNYAKALDLLVALRKGCILEQEPKQFNDFLHQLCKFCLQNDLRSFCNFLATKGITLISKTEAADSDVTEEEARSFLVKSEPKPE
The following text describes a protein:
Function:
The intein is an endonuclease; The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity.
Sequence:
MTSSELDLRIEERLPPQNIDAEETILGGLMMDPEALTRVVEHLRPEAFYVESHQIIYRAALALHAQGRPTDLLTLSAWLEDNKLTEKIGGRTYLRRLTDAAINTINIDGYGRLVSDKYALRMLIRAGQEIAALGFDSATEIPKLLDRAEQTLFAVTQERVQRSLVPASEVLMNIFEQLETRYQDGSNVFGIPTHFYDLDNYTQGLQPSDLIIVAGRPGMGKCCAADTPIADPVTGALVTIEEIYRRGEAGKLVEVLTLLGDGRLARVEPSHFVDDGIKPVYRVRTGLGREVKTTLTHPYLTPTGWKPLAEIAAGARIAVPCRIPVFGSESLPPKEISLLCSRATRDNRIPDPVFRLPRAQLVAFLKQLCITADSARVSDRTVEFTSPSKSFCHQLQHLLLRLGVLSALREVSGIFYLDIKPAAETPIKPASLWSQDLAHHCDLHWDEIASIEYVGNEQVYDLTVPVTHNFVAADICLHNTAFSLSIAQRIAQKAGLPAVVFSLEMSKEQLVQRLLCSEAGVESHRLRAARISENEWQRIGQAIGELASIPLYIDDSPNATVTEIRSKARRLQAEQGGRLGLVMIDYLQLMEGAGSDNRVQELSKITRGLKGLARELRVPVMALSQLSRSVEARTNKRPMLSDLRESGSIEQDADIVLMLYRDDYYNPDSPDRNIAEVNIVKHRNGPTGTVKLLFENQFTRFLNLTSGNH
The following text describes a protein:
Function:
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
Miscellaneous:
MISCELLANEOUS: Present with 1730 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MKWLLFPARIVARTRPNLFSLYRRSVSQYLRPRTIQNLQSMAQTPELKTKLFKPLVWIDCEMTGLDHVNDRIIEICCIITDGHLAPVKAADGQGDSHYESVIHYGPEVMNKMNEWCIEHHGNSGLTAKVLASEKTLAQVEDELLEYIQRYIPDKNVGVLAGNSVHMDRLFMVREFPKVIDHLFYRIVDVSSIMEVARRHNPALQARNPKKEAAHTAYSDIKESIAQLQWYMDNYLKPPQETESVESIGSEQPESPSSSTSSLKRQRTDF
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MDTWLVCWAIFSLLKAGLTEPEVTQTPSHQVTQMGQEVILRCVPISNHLYFYWYRQILGQKVEFLVSFYNNEISEKSEIFDDQFSVERPDGSNFTLKIRSTKLEDSAMYFCASSE
The following text describes a protein:
Function:
Primary role is to release GH from the pituitary. May act as an endogenous ligand in the bullfrog hypothalamo-hypophysial system.
Subcellular Localization:
Secreted.
Sequence:
MHLKIGTLTIRTIMLFTLCTFLTLFAFSTCFDETKTINLESQEIYDDLFESKEDLQNERNGNSDEYRYMGSNSINDINRYNRLSMQPENEFLQERSLKPAANLPLRFGRTSDDKIAKSIPSFDKIAKSIPNLPQRFGRYLSGKTKVQSMANLPQRFGRAQYTNHFVHSLDTLPLRFGRTPHSDRLQYEMNSHPLELKNPEEDSDRKKRQAMTFRIRTDLQM
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHGRPRQRAGETPPPEVNKKEQAQVAELQKIIPLFMENNRTCCYSSQALDQNARLLELNPEFYSAWNYRKRAVRHLLNLESDEEVRKRIVQTELDVVVRALRVNPKSYGAWYHRKWVIQFGLSPMDAEFLLLKKLLKLDARNFHGWDYRRFVAKTKGVAVEDELLFTTDKINENFSNYSAWHNRSALLSEISKNEAAENGRVQERLQEEYELVKNSFYTDPDDQSGWFYYSWLLGQTIAPVGTHVSGCWPPPKSLIVIDLKNNSYKLPFNKLKVGKLETLPVVICFSNSVTGVNDQTVSTTVDGNDSLELEWRPVERWQKSGRKWTTNIKNCLSSSSGQTSVKILVGAVPGITSLDGQACERSWQSSFQVLFEETSSFEDYADKYDQLCESILQSRSRTFVDSPSSLQYLFPVANHSGSNNEEADGTKIWQLGLLDREIQSCRELLDLEENSKWTRLTLTRLLLTHASYNTSSLKSHIDEARKHLEMLKCLDPTHQEYYQHQLSLLSLKELTMDEFILAGKYVREGLLKLNQLSLCSLEFADRFLWVQNLDLSHNQLRSTHGLEALQLLSNLTLSHNRIGSVTALAPLRGLPLLEDVDVSYNQIGDHTVDTCRVLCSSKLINASLVPPASSQKSDRAEWHLKEGRYWEIKVVFEDLCWQKLNIAGNSAAKDVEFVDALNRALNGTRLITEAETNL
The following text describes a protein:
Function:
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Sequence:
MPRGRDEPATVRVYIVCDESKYLIVRNVPSLGCGDELGTLFSSDGPLEECKPMDAEDCEEYTDVFFIKFSQLSNARFTKRKLDESVFLGNRLQVSYAPQFENILDTKEKLEVRRNEVLGRIRSSVGSRSERLTQYSPWQGSSSGNLHHHMSPNKREYTKTLHASHIEDVRFSHVSSNKDYFPSESMNATVNLVRQKLDKIQSGSDGSNAVAASKKPRVDDRRRI
The following text describes a protein:
Function:
DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.
Subcellular Localization:
Cytoplasm.
Domain:
Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.
Sequence:
MNNLKLSEEIKRAINELGYTEATPVQKAVIPVALTGEDIVAKSQTGSGKTAAFAIPIAEQVEWEENKPQALIIVPTRELAMQVKTECTNIGRFKRVKAAAIYGQSPFAKQKLELSQKNHIVVGTPGRLLDHIEKGSLNVDKVAHLVLDEVDEMLSMGFIDQVEDILSRLPKQRQNLFFSATMPEEMQDLIKRYQDNPMVIEMASEKTNPIFHVEMQTDNKEKTLKDVLITENPDSAIIFCNTKNQVDELTDLLDVKASKIHGGLRQEDRFRAMDDFKSGKSRFLIATDVAGRGIDVDNVSLVINYDLPIEKENYVHRIGRTGRAGKSGKAISFVKTNENPLLRDIEEMLDVTIEKKRKPTVIEVKVNEDAFRKKQQKRPTIKKARGEKLNKNIMKLYFNGGKKKKIRAVDFVGTISKLEGITAEDIGIITIEDHVSFVEILNGKGPAVLEMMRSRKVKGRRLKVNEARKR
The following text describes a protein:
Function:
Mediates the import of RPA complex into the nucleus, via its interaction with importin beta.
Subcellular Localization:
Nucleus.
Sequence:
MEAERRHRALYKGTTPPWKETYRKRCVERLKSNRSKLLDKFRQVGERIHGGVGGSFLVQEVMEEEWKVMQFENGGFPSMWKKDAFSQDPDELATLEEIKQELLLEEKAMVEEFENILQFEEQCFDSVVELSTGDQIVCPVCNRNYLTVTSCFIVCQCGVYINTQSQGMSIEKLHSLLESNLTAHAYHCNKLPVFSVATELGGAASLFMSCQECDAMVVIL
The following text describes a protein:
Function:
Probable histone demethylase.
Sequence:
IGGELKDSGGLGLEDSLSTLFKRSGRKSRQVSVKEEEGVEVAGSHGEEILEKGSGLVSDRVAKGTKRRRRRTKEEMKNAAAKSESAMAHEGSPNRKVGTSLPRKAKAEAKVKISNSNRRSKKSDEKPKASDDVLCHRSLGETIEQDAETRTVLDDGSRNSSDGASHRIEVSACLSNQPCLKPCSGELAEEVSLSAANAATDGVSNEHTYSETLLKERNDDAGCSHGKPPTLAIKSIPGKKPIEMPKKPVRQKDQLLSTDVDNKCVVGSGDTKDVNIENQPAFGIPESHVTGKGLHPHKMATSVKELDVVDVVAPTDFEDMENASKSKRVTRSSRKRKHGDMAYEGDIDWETLMQEQGLFSNLSAALVDYPLKSKDKIKISEVLDNGDGSGVAAVRAGLKAKAVTPIEKIKFKDILKRRGGLQEYLECRNMILSRWCKDVKHILDLAECGVSDVCLDDESPRQTLIRDVYLFLDQNGYINAGIASDKVKTDHESPPEDVEVSKLNESHERKSVSIQDCIVTEAVQDKKAVVKQTDCVLTEASNEESSSAAIHCDAQDLLPPLKSEELIFKEKNQGVLTEGRDESALPSNSDIHSKSDLDGFILKVEGGSLHQAEAADIEHSENKHEASDRVESGGYGKKIIVVGAGPAGLTAARHLQRQGFSVTVLEARNRIGGRVYTDRVSLSVPVDLGASIITGVEADIATERRADPSSLICSQLGLELTVLNSACPLYDVVTGDKVPDDLDTDLESEYNGLLDEMAQLFAQNGESAVGLSLEDGLEYALRKNRVTRSEQDDQLRNVSSAGAVDISESASTEKEIAHCGKEDKTDVLSPLERRVMNWHFAHLEYGCAAMLKSVSLPYWNQDDVYGGFGGAHCMIKGGYDTVLESLAKGLDVQLNHVVTEVLYGSEELGASGNSRKFVKISTSNGNEFVGDAVLITVPLGCLKAQTIKFSPSLPDWKLSSIDRLGFGLLNKIVLEFPEVFWDDNVDYFGATAEQTDLRGQCFMFWNLKKTVGVPVLIALLVGKAAIDGQSISSDDHVKNAIVVLRKLFKDASVPDPVASVVTNWGLDPFSRGAYSYVAVGASGRDYDILGRPVSDCLFFAGEATCKEHPDTVGGAILSGLREAVRIIDLVHSGKDYVAEVEALQTYQMQSDSERNEVKDMSNKLDACELSTALCKTSSDASYPLFSKETLLQEMFFSAKTTSGRLHLA
The following text describes a protein:
Function:
Essential for male fertility and sperm mitochondrial sheath formation. Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath. Facilitates the growth and aggressiveness of neuroblastoma cells (By similarity). Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells (By similarity).
Subcellular Localization:
Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.
Sequence:
MGKTIPRFLEQLDLIKSFVGLATGAGALYLLYKAVRTGLKCHPPLCSNSPICIARLAIERERHGRDSGEIRRLLNSLDCKQDEYTRSMILHNITRCVYLLEAEASSCTMDDIDLVADMLDEKDNSVKIQALNALKAFSGIRKFRLKIQEHCIKVLELISTIWDLELHVAGLRLLNNLPLPDYVHPQLRRVMPALMEIIQSDCILAQVQAVRLLSYLAQKNDLLYDILNCQVRPNFLNLFQSSQPGSLLFEVLVFAEHLSEGRNATHYRAVKWHYNEQSLHEALFGDESRLADRLLSLVIHPEEEVQIQACKVIVSLQCPQDLGSRPSSCRPSHSCFKTGK
The following text describes a protein:
Function:
Role in flagellar biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MDAATQMVIDGQRAFAMVGAIMWTMLRTGALLTAMPLIGTRAVPGRVRVMLTGTLAMALAPILPPVPEWDGFNATAVLSIARELAVGASMGFMLRLIFEAGALAGELVSQATGLSFAQMSDPLRGVTSGVIAQWFYIGFGLLFFAANGHLAVIALLVDSYKALPIGTAVPDAAAFAEVAPTLLLQVLRGGLTLALPMMVAMLAVNLAFGALAKAAPALNPMQLGLPLTVLLGLFLLSSFASEFAPPVQRLFDSAFDAARALTG
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB32.
Sequence:
MILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGRGLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTSSKPLLINPNLFKTLRPLIKLSRIFGLCPITYKNSDKCLNLRIKWSWSLYILQLIAVTVITSWAIWGFIRDMQIAEFLNLGFTSAIDLYIAIFDVNEIIITGFIFVAIIPSTFKHLPEIIDNFNKIDDTNPQLPTNKIHRKILFLLSFVLVYMTVAYTCDLIMWSQDLLVGFIHDLPYYILYSVVVIHEVQYWFLVTLIRLRMSAMNGLVAETLNRNTDISSQEVCLLVETHSNILEAVSTVNRCFSGPTAIILLSCYLHLVVCPYILYVVASSDNGLFCNTVYFLWISVHFSRLLVIIEVCNNCENECHKTRNLIFKLLANTSKKGDVRRELKLFAYKNVGKKVRFSSYAVPKINRKLLISIATSISSYWMILYQFGASTTGL
The following text describes a protein:
Function:
Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
Miscellaneous:
MISCELLANEOUS: This is one of the targets of the anti-tuberculosis drug ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB]. EMB is a first-line drug used to treat tuberculosis. EMB inhibits the transfer of arabinogalactan into the cell wall; MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLAIATPLLPVNQTTAQLNWPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGKTVLLSTVPKQAPKAVDRGLLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAHADRVAAEFVGLVQGPNAEHPGAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASVDTRYSSSPTPLKMAAMILGVALTGAALVALHILDTADGMRHRRFLPARWWSTGGLDTLVIAVLVWWHFVGANTSDDGYILTMARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVSTASIWMRLPTLAMALTCWWVISREVIPRLGHAVKTSRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATSRLLPVAIACIIGALTLFSGPTGIASIGALLVAIGPLRTILHRRSRRFGVLPLVAPILAAATVTAIPIFRDQTFAGEIQANLLKRAVGPSLKWFDEHIRYERLFMASPDGSIARRFAVLALVLALAVSVAMSLRKGRIPGTAAGPSRRIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSLGALAAVAVTGAAMRSRRNRTVFAAVVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWSLTTALLELTVLVLLLAAWFHFVANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEVVSLTQAMISQYPAWSVGRSNLQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAGLSEAFTPNGIPADVTADPVMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLPYNLDPARTPVLGSWRAGVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQWATDEQAAAGHHGGSMEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIALTPPRIPRVRTLQNVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEANSPVMDHNGGGPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTVTRSGLWSPAPLRRG
The following text describes a protein:
Function:
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Subcellular Localization:
Nucleus.
Sequence:
MTDNQKFLADNHPHLDCNANVPKPCQVLKIETGVKPIMNENAPISHMHSLDGCNGDGDHRSAQNWLTELAIIATSPQSPLMQRKSGGSSGRQRHHSEGSVLHKPTRLSAAVNSLNRAIHTYAKPPRNAPPPSFLISSSSSSSSSSHVNDEDDFIDPVGTWAPELSDARITSSSPFPASPKDSELAGGGTWSHPWPVAVWKCFLKGNMIRFTSGPRTEWRLAEEIGSNEYLATQACLIKDESGRGQSPISGYAPLGLRLVKIEDLKPSDPRLPDIHAEVYDQMKLTFDPDVKGQSCLEAICSTDHPFFVRHKGWSSYIPCQTVVRYGIPCSELESGDVCLPPSHPDATSYKESDVLESFKSYDLTPSDSAAVLALSSMARHRKDLENSPTRQIPSSPVSSSCQLSPGGSASAPSSPSKGMKKLQLVDQKGKRPMNAFMLFAKKFRLEYTQQHPDKDNRAISVILGTKWKKMRLEERRVFSQEAKHLADEHKKIHPDCWKRKRAHSTSSVHS
The following text describes a protein:
Function:
Bifunctional nuclease with both RNase and DNase activities. Involved in basal defense response. Participates in abscisic acid-derived callose deposition following infection by a necrotrophic pathogen.
Sequence:
MASASLFQTSVLSRSASRAVLSPVCSTAASVRCARSSASVAPGGWTARSVPACTPCVSGRCNRVVAQASEQGNTGSSRDPSLDGFVEVKVDQVRVNSGNAVVYLRILDGRERVLPVHIGENESNALVKEINKQRQMRPLTHDVMKNILREIKFRVVKIRITDIVANTYYARIHLAKVNDATGQPEPGTEVDVDARPSDAINLAVRFGSPMYVSKRIADAASTVYPDQPAAPNETASEIVRSVRETLASFEDPTVMYQLQKDLAVKEERFEDARSMQQLIYHEMTHNQLLRLVVAMESALSDGRYEEAARLRDEFRRLSANAPSEQRRT
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
Miscellaneous:
MISCELLANEOUS: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
Sequence:
MIGIIGGTGIAEILKGDKEEIINTKYGKARVIIDKENEVVLLFRHGVRHNIPPHKINYRANIYALKKLGVERILAINSVGSLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHIDMTDPYCPELRNILKSILDKNNFSYGEGVYVCTEGPRFETKKEIAIYKNWGDVVGMTGYPEVVLARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFGERKCICKDALKHAVIG
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Is not a genuine component of the 26S proteasome, but an auxiliary factor that interacts with the proteasomal ATPase of 19S regulatory particle (RP). Acts as a chaperone which regulates the highly structured assembly of the 19S regulatory particle. Involved in the substrate specificity of the 26S proteasome and is especially involved in the degradation of ubiquitinated GCN4. May contribute to the stability of the 26S proteasome in some stress conditions.
Miscellaneous:
MISCELLANEOUS: Present with 2210 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTKTITVAHIQYDFKAVLEENDENDDEFYINVDKNLNEIKEHKIVVLGNSRGVDAGKGNTFEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGALFVSSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNGEVLEVGKNNFCALYNLSNP