lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Subcellular Localization:
Cytoplasm. Membrane.
Sequence:
MSETLSLASPAHAPRFPLKKPIRHGSILTRESPTDKKQKVERSASHDFDPTDSSSKKTKSSSEESRSETYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAIRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVDPAGFGHMSPILTFPHSPGPSGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQSLQEDYSRAPSQQTLKEIQEAKKHIPQLQEQLSKATGSSQDGATVVFSKPLGDSLLVGEVETDGGDAMGRIDYTSGEGSRPSSDIADSPRSGLRERMSLEESPEKMEMQDNDSHSNIGSPPNRIASQIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYAELYKQTNSKETRRIFLEFHQFFLDRAAHLKVSVPEEMSSDLEKRRPELIPEELHRHYVHTMQEKVYPEVQKHLEDFRQKRSMGLTLAESELTKLDAERDRDRLTLDRERACAEQIIAKIEDVLMAAQAVEEDKSSTMQYVIFTYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDREGEEKVKRRGFPNILGPPRRPSRHDSSAIGRAMELQKQRHPKHLPSPSSVSPEPSDSAKLRQSGILNDGGDVGYLPANPTSSLTSGISSTQEGGKENETGPKQIGEAQASGDCTDATPRTPNTIFDFPPPPLDHLQEEEGEVERLAEHGTPKPFRKFDSVAFGDIQSEDEQSENDLETDPPNWQQLVSPDILSRQTPYEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILPPSELRKIFSNLEDILQLHIGLNEQMKAIRKREETSVIGQIGEDLLTWFSGAGEEKLKQAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTECPEEKEKVKRAADHCRQILNYVNQAVKESENKQRLEDYQRRLDTSNLKLTEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASSADSKHIFSPVIKLNTVLVRQVATDNKALFVISMSENRAQIYELVAQTVSEKTVWQDLIARMAVAVKEQSTVPLPQSPPCEGERDEEEPSKLKEGPQGITASNLQSPEKDLGLESTLMSKARSHSPVSAGKPEVDVLLGTKREFEKEEHAEEALKETGMDYQSPVLDPHFPVSEEQWALDALRNLDLLKQLLVRQLGVTEKGTWEDWQHVPRSRTASQGTRAGSGIHSGPGPSANHQAAQPGEARLPRRTETGRATASYGPRTSVVSPAPRDPLELASQESGARNSLAMDHVIPTPEAPPPDLEAGPDDSGEHFFDAREAHSDDNPSEGDGSERKEEEVVQLRISGNFLILDGYETVQESSTDEEISSSLGPSCTAGPNSLDCADEQERFCQDAQPDGGSSPFTPEWLHPRLGVPGEPGFGAQSRPPSGDSRSQILQYIQKIEADLEHLKEVEESYTTLCQRLAGSAPTEEHSDRS
The following text describes a protein:
Function:
Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSHRRSTVKGSLSFANPTVRAWLFQILAVVAVVGIVGWLFHNTVTNLNNRGITSGFAFLDRGAGFGIVQHLIDYQQGDTYGRVFIVGLLNTLLVSALCIVFASVLGFFIGLARLSDNWLLRKLSTIYIEIFRNIPPLLQIFFWYFAVLRNLPGPRQAVSAFDLAFLSNRGLYIPSPQLGDGFIAFILAVVMAIVLSVGLFRFNKTYQIKTGQLRRTWPIAAVLIIGLPLLAQWLFGAALHWDVPALRGFNFRGGMVLIPELAALTLALSVYTSAFIAEIIRAGIQAVPYGQHEAARSLGLPNPVTLRQVIIPQALRVIIPPLTSQYLNIVKNSSLAAAIGYPDMVSLFAGTVLNQTGQAIETIAMTMSVYLIISLTISLLMNIYNRRIAIVER
The following text describes a protein:
Function:
Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (By similarity). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage. Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation. Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions. Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (By similarity). Involved in intestinal tumor progression.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion. Note=Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner. Colocalizes with HK2 in the mitochondria during hypoxia. Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (By similarity). Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD)/reoxygenation insult in primary neurons.
Sequence:
MPRFALTVIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAAAGQFLSNVQFTHAFSSDLTRTKQTIHGILEKSRFCKDMAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRESVLPGAPGSGLESSLAEVFPVGKHGSLGANPKGGTLGLAASILVVSHGAYMRSLFGYFLSDLRCSLPGARDKLELSSITPNTGISVFIIDCEEARQPSIQCVCMNLQEHLNGVTEKQH
The following text describes a protein:
Function:
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Sequence:
MPSQMEHAMETMMFTFHKFAGDKGYLTKEDLRVLMEKEFPGFLENQKDPLAVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIACNDYFVIHMKQKGKK
The following text describes a protein:
Function:
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. To a lesser extent, is also able to utilize other nucleotides such as CTP and GTP as substrates, producing the modified coenzymes, flavin cytosine dinucleotide (FCD) and flavin guanine dinucleotide (FGD), respectively. Does not catalyze the reverse reaction to produce FMN and ATP from FAD and PPi. Does not function as a glycerol-3-phosphate cytidylyltransferase, as previously annotated in the complete genome.
Miscellaneous:
MISCELLANEOUS: Alkylation of both Cys-126 and Cys-143 results in complete loss of enzymatic activity.
Sequence:
MKKRVVTAGTFDILHPGHYEILKFAKSLGDELIVIVARDETVKKLKGRKPIIPEEQRREMVEALKPVDKAILGSLKNKLEPILELKPDIIVLGPDQTTFDEETLKKELAKYNLYPEIVRFRGYKKCPFHSSFDIVKEIIRRFCNKEIKI
The following text describes a protein:
Function:
Functions in regulating protein trafficking, retinal maintenance and lipid storage. Protects photoreceptor cells R1 to R6 against light-induced retinal degeneration by stimulating norpA-mediated endocytosis of the rhodopsin ninaE (Rh1). In the auditory receptor neurons, functions as a cilia trafficking regulator of various transient receptor potential (TRP) channel components including iav and nompC. Likely to deliver pre-ciliary vesicles containing membrane proteins such as iav and nompC to the intraflagellar transport complex (IFT) at the cilia base. Plays a role in the inhibition of fat storage.
Subcellular Localization:
Cytoplasm. Nucleus. Cell projection, cilium membrane; Peripheral membrane protein. Cell projection, rhabdomere. Note=Detected in the cytoplasm and nucleus of the chordotonal neurons. PtdIns 4,5-P2 binds to and regulates its localization to the ciliary base. In the dark, localizes mainly to the rhabdomere domain of photoreceptor cells R1 to R6. When dark-reared flies are moved into the light, the protein translocates to the cytoplasm. Under normal conditions (12 hr light/12 hr dark), localized mainly in the nucleus of photoreceptor cells with minor staining in the cytoplasm.
Domain:
The C-terminus is important for mediating light-induced rhodopsin endocytosis.
Sequence:
MSGINSRNQKMEQQRQLMEAYIRQKRASPGMVQASDLQINRPMSGMRSNSRELHAYDGPMQFISSPQNPDQILTNGSPGGINPVAMNTSRNHSNNMRSLSTINQEADLIEEISSHELEDEESSPVTVIEQHQQSASHSANSTQSQKPRARQHSFSDNLDEDDYTNRNVAGAAPVRPAGMASSPYKDATLDGSSNGTGNGTGGESEGDVIGNIDQFVMQPAPQGVLYKCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVSCDPTDLSRNADGFCGKLRSNVFGTSFTVFDNGNKESTESPRLDLAVIIYDTNILGFKGPRNMTVILPGMTEDDQRVKISSADPKQQGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLNFHGRVTQASVKNFQLVHDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIACE
The following text describes a protein:
Function:
Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSGKLAAPHISPLLRIIPHIIGLLPLVLLIGDGLADRLTVNPIQYLTQRTGWFALILLLATLACTPLNRWFGWKQVMRWRRPLGLYSFGYAGLHLAIFVALDYGFDLSLILQTISEKRYIIAGLLAFALLLPLAITSTSGWQRRLKHWWRRLHRLVYLAAILAVIHYLWLSKDPRPALIAGGLLGILLLSRLIGRQSWQRMVQWSHERIKRQISSRR
The following text describes a protein:
Function:
Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle. Note=Observed only in the cytoplasm of ciliated cells and absent from cilia.
Sequence:
MGFDIDSQKICSDLESSDRRLKTTVLDELLDKCKEATNSESADKIADVFDKLYLHLLKCYEDRFESVRSKAIQVVSAFLSSLPPTDFHLMNVVSTLAERMGKAETVEPSEEIRLLYIAQLNLMICLYEKMENVGVFRECYPLVVKILIKSIKDDYPVVQREGCSAVVTLSRLADTQEFRPFTESILLPLYTMLNHKHAQARISAIQAIARLSLHMDASGDAMRRLFNEVSPLLMDTMPLVRREVGQMGILMLMELLDRYSFFERILPLVLCCLKDESPEVLNHIYPQWLKCGIQYFNENEAELSQQEISDLPVENYPKDVKRPTIGCRGLVQRSLRLLQLITRETSDWKDNVRLHALKLLYQFVLHAEAAMTAKFFEIYGDLAHACIDHVAEVNAEAAKVADLMGRLLSYDAWIDHGFDGLERNARESYMRCFYHMFTASLGGTYEQLMRLAKLLRCTDYSHTLKPGFQHYILKLLNTIVDKTLKINAGQNELEDLYESVYVCAIKVMALSSSLENVGDEDVNFGQTLIEKMVKLLNTSVPKIHERWFHLALQDVINLDAALEDNAEPVMLLNGLINMCHIRATYVHDLIEKVKIVFQHCCDSAQVKIFSSLSLATLFWSKTMNVERESSTQMLSEFVSQIVEPYLTWKAGSNAEAMRSLAMATLCALAQGAESESVEVLPSLAKYMPSLLEDRNVTTRHYAIKAVVYFREMSVEDLKPLAYATMQRMDDPSAGIRILAALAMGKLKPKFAETDTEENYEKEVWDAIVKRAMDLLLLYHESPEKDMRAAVAVTLKVLAKSHPEAWEERYQRALPMAQKKDLLTELYDKLTINEDSHTEVTSASQD
The following text describes a protein:
Function:
Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSEALDEES
The following text describes a protein:
Function:
Plays a role in mitochondrial biogenesis and protein folding.
Miscellaneous:
MISCELLANEOUS: Present with 7570 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MAFQQGVLSRCSGVFRHHVGHSRHINNILYRHAIAFASIAPRIPKSSFHTSAIRNNEAFKDPYDTLGLKKSATGAEIKKAYYKLAKKYHPDINKEPDAEKKFHDLQNAYEILSDETKRQQYDQFGPAAFGGGGAAGGAGGGSGSPFGSQFHDFSGFTSAGGSPFGGINFEDLFGAAFGGGGRGSGGASRSSSMFRQYRGDPIEIVHKVSFKDAVFGSKNVQLRFSALDPCSTCSGTGMKPNTHKVSCSTCHGTGTTVHIRGGFQMMSTCPTCNGEGTMKRPQDNCTKCHGEGVQVNRAKTITVDLPHGLQDGDVVRIPGQGSYPDIAVEADLKDSVKLSRGDILVRIRVDKDPNFSIKNKYDIWYDKEIPITTAALGGTVTIPTVEGQKIRIKVAPGTQYNQVISIPNMGVPKTSTIRGDMKVQYKIVVKKPQSLAEKCLWEALADVTNDDMAKKTMQPGTAAGTAINEEILKKQKQEEEKHAKKDDDNTLKRLENFITNTFRKIKGDKKN
The following text describes a protein:
Function:
Involved in pre-rRNA processing. Required for the final stage of 3'-end maturation of 5.8S rRNA at site E.
Miscellaneous:
MISCELLANEOUS: Present with 3570 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTQDKEVKVVAPDVAPDQEVEINKSVKDAKHQTNDDSLLQHKKKGKKGKKSKPIVTPEHIAKVRAEREVMRKAKRDAMLAQGVDPDCPPELHFIRRPFLSLHEAEPVTGFRFKLMTYNCLAQALIRRKLFPDSGDALKWYRRSKVLLNEFKYYNSDVICLQEIDHIQFQSFWKDEFSKLGYDGQYYRNATKNHGVAIMWRRELFHQVDKMLIDYDKESSESISTRTTTNNVGLVLALKFSEKVLSNLGKKSSKKCGILIGTTHLFWHPFGTYERTRQCYIVLKKMKEFMHRVNVLQNENDGDLSHWFPFFCGDFNSQPFDTPYLSMTSKPVHYRNRAKTVIGCSTSYKFSKVRDGEEGADDEEGGNIEKYGKDQPESPVPEKFHANEEQSELVDKMAQLHNSLDMRAISLYSVGYKNVHPENAGLDNDRGEPEISNWANTWRGLLDYLFYVKKWDPQSNCQEVETLGDFEKENKVKCRGFLRMPPGNEMTKHGQPHVGEYASDHLSMVCDLELQL
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MFGTTILALAFALLYLRRWQQLKREVARRIEAERLFRETFEHIKLLAIQLDTHGNLVFCNDYFLQLVGWERREVIGVNWFERFVPPDQKTVKRIFYSSLDTGNIPVHVQNDIVTCGGRRLFISWTNTVIRDSSGGIIGTMSIGDDITERTKAENALLSYQEEFRNLAAELSLAEERERRRLSTDLHDLIGQTLAFAKIRAHSLREHVAEDGLTQWGELTGLLDQSIQEVRSLIFQISPPILYEVGLEAALEWLGENFQDNHRFRVNFSDDGTLKPLREEIKVTLFQVVREVLINAAKHASPDTVQIDIRGLGESVRITVRDDGRGFDVAKAAHKSRDKAGGGFGLFNIRQRIERLGGSLAIESSPGAGTMVTVVAPLDLARDTH
The following text describes a protein:
Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Sequence:
MKEVRVVICGDQGVGKSSLISALIQEDNVTSIPKVFPIISIPSNPDSNDDVSLVLVDTQSDSNEREYLAAEIKKANVICLVYSDNYSYERVSIFWLPYFRSLGVNVPIVLCENKSEDLDNYQGLHTIEHEMIPLINEFKEIEACILCSALEKINVNELFYMCRACVIYPITPLWDAKERTMRKATIHALSRIFFLIDKNNDDLLSVDELNSLSEKCFSKNLSIEDASEILSKVKEICPEGVYEGQLTLPGFLAYNRVQVENGKQESTWGILRAFHYTDSLSLDDSYLSPKFEVAPGQIVELSPKGYRFLVDLFYQFDRDNDGALNNEELSALFRHTPGLPEIWVSSQFPNSTVLNEHGYVTYNGWLAQWSMITLFDYKTTLAYLAYLGFDTDGRGHNTDALKVMRKRVSQNRKVSKYDRNVFLCFVVGSKSCGKTALLSSFINNNTNRLTPNTVVNSVEFQSTQRYLVLSEIGETDLDILAEPKSLEACDILCLLYDSSNPNSFSFIANLLNLYPDLQKIPCVFAATKADLDRQQQRYPVQPDEFTKQLGLPSPTHISTAAIWNTSKEFFIQLAESAQYPASSIIRIPEEDSNKTNYQLVAALTAFGALLLSVGGSLTWKIIKHQYYSKK
The following text describes a protein:
Function:
Involved in the control of meiosis. Represses the transcription of the IME1 gene thereby inhibiting cells from entering meiosis. But also activates the CLN2 gene thus promoting mitosis.
Subcellular Localization:
Nucleus.
Sequence:
MSPCYGQNSAIAKGSWNREVLQEVQPIYHWHDFGQNMKEYSASPLEGDSSLPSSLPSSTEDCLLLSLENTITVIAGNQRQAYDSTSSTEEGTAPQLRPDEIADSTHCITSLVDPEFRDLINYGRQKGANPVFIESNTTEQSHSQCILGYPQKSHVAQLYHDPKVLSTISEGQTKRGSYHCSHCSEKFATLVEFAAHLDEFNLERPCKCPIEQCPWKILGFQQATGLRRHCASQHIGELDIEMEKSLNLKVEKYPGLNCPFPICQKTFRRKDAYKRHVAMVHNNADSRFNKRLKKILNNTK
The following text describes a protein:
Function:
Inorganic phosphate and probable anion transporter.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MARLTLRPHNHFFSSPIYAHKQPFLSVYTIFPHHHQNPLIKSRVKCSASGTERVRESKKLPPKDPIEDPKPQLPIPEVLSTETGFEQNWPPWKNIPQRYKLIGATSLAFVICNMDKVNLSIAIIPMSHQFGWSSSVAGLVQSSFFWGYALSQLPGGWLSKIFGGRKVLEIGVFTWSFATALVPLLAGFMPGLIFSRILVGIGEGVSPSAATDLIARTIPVKERSRAVGFVFGGLSLGSVMGLLLAPPIIETFNWESVFYLFGLLGVGWFVGFQFLNEEEVSYKGNEISTSHKSENATKEELGSSLKEIPWKSFFQSPAVWAMIYTHFCGSWGHYTCLSWLPTYFSEALSLNLTEAAWVSILPPLASIVVTSLASQFADYLITNGVDTTTVRKICQTIAFVAPAICMTLSSVDIGLPPWEIVGILTAGLALSSFALSGLYCTHQDISPEYASILLGITNTVGAVPGIVGVALTGFLLDSTHSWTMSLFVPSIFFYLTGTVVWLAFASSEPQTFRKEDS
The following text describes a protein:
Function:
Serine/threonine-protein kinase (By similarity). Has a role in meiosis.
Sequence:
MPALLKINKKKNGQTKIDRLFSKRRKTSLAIEKNHSKASMCTGQSPLNIISYNVPPLIVLRNKTIRNSIEVLVEEMFRDIQMRQQTNVLVAQCPRMIVETQLIGLFQSNYTSVAEELEQSIRTGDIRRLYLNRSDKFCGESCLILRPEFDKLFTYYLCKFKDQEHIYTLIFKLHKLLIENPLPSYTSEELKFNWEERRLLISMGFLILAGTDSYGISLPNLGIFTHILRNSRNDLSNYLKKRPYREVIESSLYNRNVSVACKKKNEAFFGWKFRLCDAIGAGLVDSFMTTCGRAFRLTKKGLEMKF
The following text describes a protein:
Function:
VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia. UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97.
Subcellular Localization:
Cell projection, cilium. Note=Recruited to cilia in a VCP-dependent manner.
Sequence:
MATEAPVNIAPPECSTVVSTAVDSLIWQPNSLNMHMIRPKSAKGRTRPSLQKSQGVEVCAHHIPSPPPAIPYELPSSQKPGACAPKSPNQGASDEIPELQQQVPTGASSSLNKYPVLPSINRKNLEEEAVETVAKKASSLQLSSIRALYQDETGTMKTSEEDSRARACAVERKFIVRTKKQGSSRAGNLEEPSDQEPRLLLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMEVPRRRFSDLTKSLQECRIPHKSVLGISLEDGEGWP
The following text describes a protein:
Function:
Lipid transfer protein involved in seed and ovule maturation and development, probably by regulating the fatty acids homeostasis during suberin and sporopollenin biosynthesis or deposition. Contributes to pre-invasive defense against some non-host powdery mildew pathogens by preventing the penetration of the epidermal cell wall by the fungal agents (e.g. Blumeria graminis f. sp. hordei (Bgh)).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MEKSTRTLFITIVITSMLLGFGNSDLAQDREECTNQLIELSTCIPYVGGDAKAPTKDCCAGFGQVIRKSEKCVCILVRDKDDPQLGIKINATLAAHLPSACHITAPNITDCISILHLPRNSTLAKEFENLGRIEDNYNSTSPTQIHKDGTGGGKAEPVKSNGWKEKSWLGVELLIYLLVSLIFF
The following text describes a protein:
Function:
Loosely associated component of the core of photosystem II (PSII), it is not always seen in crystals. PSII is a light-driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating a proton gradient subsequently used for ATP formation.
Subcellular Localization:
Cellular thylakoid membrane; Single-pass membrane protein.
Sequence:
MDWRVIVVVSPLLIAATWAAINIGAAAIRQLQDVLGREA
The following text describes a protein:
Function:
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MLVLTMFTWTSKTVLQCLQRPARCALVLPVCNIIEKSHRTLFHTQHQSLNDKTFPGDHNGTITDGQREKIILDAVFGPVISKKKKQNKTQQRKDKNDTEEGIDLLQDSEVPPAKLGLPPDLQYMLTMKQKTNKSQRVKRKHKKAGEVGSASTTSAEVTSHDEQDDSPSEHVGPAKMPSNPKWSVRDNASFPQFPMTSVLAQQEPPVQETPMTVKPERRIDVETGDSVPDLGMPSVGSILRKTMPPESVLVLERWKARMISELGEEGFKKLQEDTFKEGETIHTAIDALLTGTPERDLTIPEENQGHWASIQHILADISDVSVVESVVKHPELQYGGILDCVAKYRGQWCLVDWKTSKRLKPTLKQCYDIPLQVAAYMGALNYDDNYGFQVEKALLVIAYGNGDKGHAHLLPPALSEHYWRQWLKRLHQFNRRFRHT
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSIMKPTTRFFRFNSLELAVSPFQRIYGQLRFLRKQPKPFLVKLLNNEVSKLGRQGDVVSVTRGYYRNTLFPKKQAIAVDALKSMKAHLLQGSEFSTKTKE
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MSVVMDRPFSFGKLERQKPIQMISGSFENRCRPSCSHQVQPLGQNSHQATWDREYEDQLSQMGMHRSSVKTSRVQGEVEEQRSAAGRQLLSFLDSQSTLCFQKYLHFYFFSFPLERYCVCLHCCGPARACSLQGVDCQGRQVFYFESPLRVDACCLGSCLMEIRAYLPQKRIIGTVGQRWSMFTPLLEMCDSEGSSTIRIQGSCCPGDFILKIVSSIGEPIGSIWKKWPGFNEEHNMDHDCFGLEGEKRTFELKQLPLVFVQNHMVFEMSRAVQMLLHW
The following text describes a protein:
Function:
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway.
Subcellular Localization:
Apical cell membrane. Cytoplasm.
Sequence:
MPKEKPCEVPLPVGWEEARDTRDGRVYYIDHYSHRTTWIDPRDRLMKPLSFSDCVGNELPLGWEELEDASGGKYYIDHNTETQQTEDPRIQWRQQQEDMLKEYLSLAQSEINEKEDFLNVKKQRLNVAQEEFQYLTSQLENMENHNLSPKHLKQPSSTSSASSASGKSITSITSKYDPCQLKREIIQAKTRVERLRSEMEKVSVEVQAKKEGFRQLENVDKRFSSSIPCNSEEMLAMSDEIQSVQRNLALKEKEKAELIQTLVKLRETFNTKGEISERKEESFNKKTNSSSQTDLSIDTPPDKRELKLEYKESVKERQRLQSEIDKINEKLSNCSSTEESPRPISASTNTLMLIQEKEALLQELRRLGSLLRTEEEKLQLEKERDKLAADLESARELSHRVIADRMQLQAEKSILTQQLAEQAKLTNLLESQLRNMSASTPSLSSCSSKGSLSTESRGSLSSSRGSLSSLNYTDSGFLNNNEQPNLRELHQKVTDMLHAYQPVRTCAVPTSYVSTSLSASRIHTSTSSPQMSFSSRDSLSVSSLSPPISPSAVDHQSTSPGAMRVTVTQAETTAGLEGTESERALVTQCGGVSNTRPVTAAASDESVAADSGVFEASQENLKVSQSSNDLRAHKEGEEDTSAPAQIKIGLSYDTDLEALLVSIEQGKNLKELQGREAPECIAINVKLQLLPGDGVIMETNLSNDLDNPTYGEQFHIPLPESKLVCKTLQVHVWAVTKYKTEELLGGSQISLAEFDTQSPIRFRWYNLLNYSYLSPLKTLNKGQMASAVSPNLMGVAVETLGVRTLESRMRPSSWCCGGSTHSLASTGGESSPSQSASQEMLNIDPQQMVGTRRSPARHMEREHSQEDSVVSGDSLQDRLESDFDRSVSRPALRSPYLPIRGLERKYSDPDPFQSFTCMEESLNNHPLRSKAYDINLNRSNSDCTARKTDRSPFVRLSVERSSMRRKKRPVSWQGVQQYQHLQMMQSLPFDMFRYSDLENDQDIMPRQISGDIARLHRLKQWIEKALADGSTDVPKWLEDSEEYRSLVREIEGRQMRLPRVARRNHKAADLKLVREKRASFSSSKSPKKPVYKDTYIEDKFNKEHKAWGGKDPCICTEPQLDKFRFIWISMIEKPVYKDTYIEDKFNKEHKAWGGKDPCICTEPQLDKFRFIWIFMIEKPVYKDTYIEDKFNKEHKAWGGKDPCICTEPQLDKFRFIWIFMIEGFSQQENLII
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDISKVDSTRALVNHWRIFRIMGIHPPGKRTFWGRHYTAYSMVWNVTFHICIWVSFSVNLLQSNSLETFCESLCVTMPHTLYMLKLINVRRMRGEMISSHWLLRLLDKRLGCADERQIIMAGIERAEFIFRTIFRGLACTVVLGIIYISASSEPTLMYPTWIPWNWKDSTSAYLATAMLHTTALMANATLVLNLSSYPGTYLILVSVHTKALALRVSKLGYGAPLPAVRMQAILVGYIHDHQIILRLFKSLERSLSMTCFLQFFSTACAQCTICYFLLFGNVGIMRFMNMLFLLVILTTETLLLCYTAELPCKEGESLLTAVYSCNWLSQSVNFRRLLLLMLARCQIPMILVSGVIVPISMKTFTVMIKGAYTMLTLLNEIRKTSLE