lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MDQQMALTWGLCYMALVALCWGHEVTEEEETVPLKTLECYNDYTNRIICSWADTEDAQGLINMTLLYHQLDKIQSVSCELSEKLMWSECPSSHRCVPRRCVIPYTRFSNGDNDYYSFQPDRDLGIQLMVPLAQHVQPPPPKDIHISPSGDHFLLEWSVSLGDSQVSWLSSKDIEFEVAYKRLQDSWEDASSLHTSNFQVNLEPKLFLPNSIYAARVRTRLSAGSSLSGRPSRWSPEVHWDSQPGDKAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEKCSPVVKEPQASVYTRYRCSLPVPEPSAHSQYTVSVKHLEQGKFIMSYYHIQMEPPILNQTKNRDSYSLHWETQKIPKYIDHTFQVQYKKKSESWKDSKTENLGRVNSMDLPQLEPDTSYCARVRVKPISDYDGIWSEWSNEYTWTTDWVMPTLWIVLILVFLIFTLLLALHFGRVYGYRTYRKWKEKIPNPSKSLLFQDGGKGLWPPGSMAAFATKNPALQGPQSRLLAEQQGVSYEHLEDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPNVQVEGPIPSSRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLGSPQVGGSLKPALPGSLEYMCLPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENPPVELSVEKQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAATSPPGHPAPPVASSPTVIPGEPREEVGPASPHPEGLLVLQQVGDYCFLPGLGPGSLSPHSKPPSPSLCSETEDLDQDLSVKKFPYQPLPQAPAIQFFKSLKY
The following text describes a protein:
Function:
Involved in mRNA processing and export. Required for efficient splicing of a large set of pre-mRNAs by efficient co-transcriptional recruitment of the splicing machinery. Remains associated with the mRNP during early steps of translation elongation.
Miscellaneous:
MISCELLANEOUS: Present with 78700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, Stress granule. Note=Nuclear at steady state and its import is mediated by the karyopherin MTR10. Export is dependent on active transcription and the export of mRNAs in general.
Sequence:
MSEAQETHVEQLPESVVDAPVEEQHQEPPQAPDAPQEPQVPQESAPQESAPQEPPAPQEQNDVPPPSNAPIYEGEESHSVQDYQEAHQHHQPPEPQPYYPPPPPGEHMHGRPPMHHRQEGELSNTRLFVRPFPLDVQESELNEIFGPFGPMKEVKILNGFAFVEFEEAESAAKAIEEVHGKSFANQPLEVVYSKLPAKRYRITMKNLPEGCSWQDLKDLARENSLETTFSSVNTRDFDGTGALEFPSEEILVEALERLNNIEFRGSVITVERDDNPPPIRRSNRGGFRGRGGFRGGFRGGFRGGFSRGGFGGPRGGFGGPRGGYGGYSRGGYGGYSRGGYGGSRGGYDSPRGGYDSPRGGYSRGGYGGPRNDYGPPRGSYGGSRGGYDGPRGDYGPPRDAYRTRDAPRERSPTR
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
Subcellular Localization:
Nucleus.
Sequence:
MSDQIHDHNDEPIEDSDDTAPSGSRTAQERKCPWCPKIFPEGLSLKKHLGRIHASHSIIQDSRKKEGSGRLLCAKRGCGQMLVSYDALCRHCADEHDFVLNYESLRFDNSDHFKSWLTHLTSISGDMVKRRGERRTSDGITMGDFHCVFDGKKRETPSTRAPDRNPYNRRVPSKKLGFACPAFIRFQILNDGSVTVRAQLQHFGHDLKPRDPGHTISKVARHGLNLMRKEKRRGYAFDGLNYDEVHPQHMNPSISNDDEQIEVDEQGMVNLFSCSSLEQARFYAQSSFASLEIAFAEVQSIPQENVLHVGHLIEKLHEIADAASRIERMVKELETIPADSSRINDSAKRKMHKIPRLHEKIVVKEGVDDEKRGLRRENGSNEEECFDRQSDCGEVEYEGEVAEEIIVDDDDDYVHDKEERDEQDSINNSAQQRPFITIMGDELPEIEVSPHWLRANEESRERVHHSLERNQWRAEIERIRSEPSLTEERLWCNTDLFDKLIEIKKELNGYKLSDFEAVRKRSNPHEPLLENKIMIGRYSLILASVDRITDFLLTEENIEDAVTKRPLDTRPRGKNIDRDAEMFYFAESQTLPIPFASQYIWLRKGFYNAKCFSPQLSPTSPLCPLTSHAFLDTVRRVAHKTKDDHFESCNPYDPSVREVFTDLILRGTHGEGVHLYAGFTHNLSPYKENYGDDPSSGNESSSMEVLFRDSYVSQLLYATRVVRKGGRAILHFLDTNTSLSMSVIYLAHIVFDRVSIYKPNMSRPANSERFLICDGLRSREAKAVKKYIEESIERVRDGESLIRLFPDGVMEEDEYFIEYSREANDKLTERQFRFLECYRRMLNDEQRENCHQKECLDTCLPYYLVPYATQDEMKNLHIEMKNRTGMDILSSWIPDGIKSVDLIRSLSSHNTKMNQLLFKEKIECNTRLFVSPCADSSAILIVANNNGIEFWSGICKEWIGMTKHTTVLPTDTILIGDIIEVADGRTLILRILDVGVIFGDDVSSLPFKKRLQAADKLVEATKKEGARQDVFLSVAQYDEVDKGWKPATIGERVVENDIYFKKKRIRIVEDSNVSFFNMVYGKKESRERIVNGLERKEWIRAETMKMNSRRGEEEREREGRRERGESEPLAMNEKHGNEGNYEQGNYENIIYIIVNLKYYGLIYWKALRYFYFRMSLLLASVHRLFHFLLTHENIDDAEFELNDFLDETTIGNHSTRAEHRSKERSFLFCRNFNFSDSSFCPFTFTMRRDFTTLVLRGTRNKGVHLYAGFTHNRRNPLISDKDQSRGDQGQKVSLYLIHFTISMIMRSEQGESTGLYMHLHLFEREEGPFFNLSTLIPPLQSINNGRSLVVRILDAALIYGFLFNISTFLLNKRLLLAEKMTEACRKPDGSSSQMIENPYRFKRVYSRIVEDSSNSFVDLCRGERLYEI
The following text describes a protein:
Function:
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane. Late endosome membrane.
Sequence:
APGSNPGSTTRLCARGQVALLLRASVPSSAKWGRRACAPCGTGTNLDHLESVCGYLMKYTNLVTGWQFRFFVLNNEAGLLEYFVNEQSRNQKPRGSLQLAGAVISPSDEDSHTFAVNAASGEQYKLRATDAKERQHWVSRLQVCTQHHTEAIGKNNPPLKSRSFSRASPGNGSSPVAQRRPSQSASAGSLAGPPAHARPLPAARGEPLQLDHLVQVQEMMTHAKGQQRDLTKTIEGLPASGHLSALDQDLLLLKATSMATLGCLADCFHILQLQHAAHQKGALLPPGPAVGWPDPRGPLPDRYENGADGSPVAGPEKPGAAPEDQAAPGAGLSERAPEEVDPDEEVEDAGEDEEDDLGTVEEQRSVILHLLSQLKLGMDLTRVVLPTFTLEKRSLLEMYADFLSHPDLFLAIPGGRTAEDRMVRFVHYYLTAFRQGRRGAVAKKPYNPILGETFHCSWRVARPAPPAADGTPAAEPGSYTVRFVAEQVSHHPPVSGFYAECPERGVSVGAHVWTKSKFLGMSIGVTMAGEGLLSLLDHGEEYTFTLPSAYARSILTVPWVELGGKVGINCAKTGYSASVVFHTKPFYGGRVHRVTAEVKQNPGNAVVCRVQGEWNSVLEFTYSNGETKQVDLTKLPVTPKRVRPLEKQGPYESRRLWSRVTEALRESELDKATEHKRVLEERQRSEERHRAETGTPWHTKYFLPEGDGWVYRKPLGKTAPKPQPDD
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MTGATGSDSTPLLGVSQPISMAKPTEKEVVMSDQLDGTLKSFNLYESEEEMETRLEVLRNVNSLVKRWVKEVSLTKMPADECEKVGGKLFTFGSYRLGVHGRGADIDSLCVVPRHIDRSDFFTSFYKMLSEDPNVTDLHAVEDAFVPVIKLYYNKIDMDILFARLALKEVPDDQTLHDDMLLKNLDEKCIRSLNGSRVADQILRLVPKVETFTLTLRAIKLWAQNHGIYSNVLGFLGGVSWAILVARVCQLYPNYAPSKLVNRFFMVFAKWEWPHPVLLKDIDSSPRPDISALHDLIPSHADHYSRFPRTEFDIQRLEITTDIMEGHCEWKELFEEVNFFSRYKHFLVVVCSADSEEHHLVWEGMVKSKLRHLIGSLERNPRITLGHINPKTYKPNMNPCPFQIGYENPVAEMWFVGLEFNKSMMGTKNVVLTEEITGFHDTVNRATRYSKGRETFTDDMKMLLNYVARKDLIKWIPKSELTKGRGARKPPSATASSLPSTPRAVIERRQSTSTSVEATSTPSTAGEVSSTTPSEAGPSNGGEKKEGDDKEKEVPMEDGTNGEVMDQTCSSSSTSSEAVVTSSTVAETPPTSGLPSVIKLSHSTSMPNLGASATSDRQPAQQLPLSNPDEANAANPIPTETVKNDLISGIDSRLLNRKRSAEGIIDDDSSAHKARRMEAV
The following text describes a protein:
Function:
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Sequence:
MDFKNKKWLFLAPLAGYTDLPFRSVVKKFGVDVTTSEMVSSHSLVYAFDKTSKMLEKSPLEDHFMAQISGSKESVVKEAVEKINALEHVNGIDFNCGCPAPKVANHGNGSGLLKDLNHLVKLLKTIRENTSKKITSVKVRLGFEKKIPKEIAHALNDAPVDYVVVHGRTRSDKYQKDKIDYESIALMKKILKKPVIANGEIDSVKKAFEVLQITQADGLMIGRAALRAPWIFWQIRNNTTKLPAVVKKDLVLEHFDKMVEFYGDMGVIMFRKNLHAYAKGEMQASAFRNCVNTLTEIKSMRESIEEFFNQEMLQSEVPLWVELNQKSV
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MEMVDLRLRLGSSSGGGDDDEPSTASCNSRVARLFESSREYHHQQQQPQQITLLYDGRICACDVTEMQARAIIAMAKREMDGHMKKTTQAHRQPIESSLPPSSPRPVERLLINPELSMKRSLQRFLHKRKSRLHALSPYGHGPQNLYSIKS
The following text describes a protein:
Function:
Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.
Miscellaneous:
MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 8]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli; [Isoform 2]: Cytoplasm. Nucleus, nucleolus. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum.
Sequence:
MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCDVVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGGHRKPLFAIHWSVQRLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLNNLENIRYNEIKEFSDKIKKEFTFSQKKQVMDIIEKLNKDSRKNVIKLGQALEKFLNKYEEELKRTNNMYNFDRRYGNNYLIAGVDEVGRGPLAGPIVAAAVVLDLNVEEMQRIFNIKDSKKLSEKKREELDIIIREKAISYNIALVDNKTIDERGISWSNNEVLKRAVEGLKVKPDLVLSDGYAVKNLNIRNEFIIKGDSKSISIASSSIIAKVYRDSMMKEYSKGLNMYGFNHNAGYGTEEHVQAIKKHGPSKIHRMSFLTNIL
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MFRSSEPVSPLDDVVTKATDENLTTENWQYILDVCDEVNNDPENGAKNVITSVTKRLNKKFANTQLYALTLVISLSSNCGSKMQQAIASKAFVKTLMKLANDSAVHKSVKSKVLEVLEQLTDEYKKDPSLRLIEEAYDELSRKKPDLKAPAKPEKHKITEQERQREEEELQMVLALSLSETNTSGSFQQHHQTNSQIQPPVNNSHFATDPHQQQQQQQQQHNQQDYGQQSNNANTNNNAPAVEDPTPTVATVSRVKALYDLNATEPGELSFRKGDIITVLESVFRDWWRGSLRGQVGIFPLNYVMPIAEPTPAEIEKEAQEELSVFSQSRNIEKLLALLSSQDAARLNLAENEELQSLYHSTLAIRPKLVKLIDKYAQRKDDLVELNEKFVKARRVYDDLMEASMPQYGGAAAAGGYAGGAQGGAPAGYPSAQGAPAGYPGTSGTPGTPGYPPQYPPQQQQQQQQQQQQQPPYPVQPLQTHQQQPQQQQQQTPYPVHQYDNTQAHGRQGSTDSGRSQRMYSQGGQGGQGPTDLHPATTGGSGYGFPPQYGGGAPSAPSAPHGGAGGPGGPGGPSAPSGAHSGAPSAPPSHAPAASAPHGYGSPSTAHSAPYGTSPAASAPARHSPYINGTPTSNLGQQSPVTSQSIPIPNNNNLAAPPVQGLYSHGTSPPPPVPNAGPPPSNFYE
The following text describes a protein:
Function:
Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers. Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity. Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway. Aids in combating extracytoplasmic protein-mediated toxicity. Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50% but has no effect on phosphatase activity of CpxA. Has mild protein chaperone activity.
Subcellular Localization:
Periplasm.
Domain:
A region in the N-terminus (residues 55-61) probably interacts with the periplasmic sensor domain of CpxA to inhibit its kinase activity and is also important for CpxP stability. The homodimer has an elongated cradle shape; a hydrophobic cleft on the convex face may interact with periplasmic protein PapE.
Sequence:
MRIVTAAVMASTLAVSSLSHAAEVGSGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSELETMHRLVTAENFDENAVRAQAEKMANEQIARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSSSNSRSQ
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTSVSHTPHVDTGLAAGRSQANSRRWVVTANMVLGHAVAVPAALLVLAEIVVLSAGIVGRYVFRSPIVWSDELAGILFLWLAMLGSVIAFQRGEHMRMTAIVGVLSAELRAFLDVIAAAASLAFLVLVVWPAYEFAADEAFVTTPALEIVNTWRAAALPIGIGLMLIAAVLRLIRIASLRSLLASLAIVAGIIGTFILLAPVLKALGNLNLLIFFVFVVGAMVFAAVPIAFAFGLATVGYLALTTSTPDVVMIGRMDEGMSHLILLAVPLFVFLGLLIEMTGMARAMVSFLASLLGHVRGGLHYVLVGAMYLVSGISGSKAADMAAVAPVLFPEMRQRGAKPGDLVALLAATGAQTETIPPSLVLITIGSVTGVSISALFTGGLLPGVVLAIMLAAVVWWRYRREDLSHVKRATGRQIGRAFVIAIPAIALPFVIRTAVVEGVATATEVSTIGILYSACAGLFIYRQFDWRRIYPMLVETASLSGAILLIIGAATGMAWALTQSGFSASLAKFMTSLPGGVPVFLAVTIVTFVILGSVLEGIPAIVLFGPLLFPIARQVGVHDVHYAMVVVLAMGIGLFAPPFGVGYYAACAISRINPDEGMKPIVGYMIALLIGTLIVAAVPWLSIGFL
The following text describes a protein:
Function:
Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction; [Isoform 2]: Secreted; [Isoform 3]: Secreted.
Sequence:
MMETCARRVLFTAALLVLSTVIAETFSTDSDTDNPLSTETFYSRASGLKQTSSWPGREATATAVDLSSGLGEMTEIPASVSITAAREGHSPKPLQTSTNAADWKTSTTSDETTEHLQSDTELTHNATAQWESPSSASHSITSHHPVTETRTVRDVTDLIDMDTTDSVSHTDSTYISTTNRVGERTLLSVISNSTFAYTQNSSISDAESQTSPWEEKTSGATQVNEETEETVSTVSEQTDPTFEGRNTTSATLETERSTLSQGTESQTGQPSVTGQTAKEVTDIDNPNSTPPLTVTSRDVEETDATSVSSETSYTQTSSDSASSILPFTSSEHNVTSTSQESHNSTLIYSTNTGGSTEFSTGSVSSTAHEETERSSTRIVDETTLHDVTSAPPVLEDVATTIDDSLSKFPSGQSPTIPKTDDQTNTQVVPTSTHRPQVTDEATDEVSTVYSSTTTLTTTTPSVTTRQLQPHYTTVQTQTQHTTIVTTDIIQVLRTTPSTAHHVPTLTTSGPQAPSTADSSDVTTLHLETSTATPGNTTAHGGRATTPFSKSSPGRTTVVVTTGHLTDKSTTETGSATTQMPLRTSASPGHVCGPKTCANGGHCVRSAEGSYYCQCLSAWTGPFCTEDVDECVNSPCPQGSVCVNTGGSFSCECDLGFDLEDGRSCTQVKTFLGTFTVNNSLHLRNLGLHELHREIQQLLNASLSIFHGYRRFTLGKRDGQGVQIPVVSMFSLSSNVTSADVFNSIQMSLNNCSRTYSHCPIKLQHQLSYHVESLCMAQKTKCDVQYSDCSDISGIPNCQCLPGYFKRNPEDMTCRDCGDGLKLVNGKCVECMFGFGGFNCNNFYKLIAVVVSPAGGALLLIVVIALIVTCCKKDKNDINKIIFKSGELQMSPYAEFPKSNRVSMEWGRETIEMQENGSTKNLLQMTDIYYSPALRNSDLERNGLYPFSGLPGSRHSCIYPAQWNPSFLSDDSRRRDYF
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Domain:
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MTVKYSINELLVDHESLSDNFTCPICFDLYYSSSSKKEVFQCRDGHLACKSCWSDSLLNKKECMICRTPVNSMNELSRNRFIENEFLKKKVYCPNSFFFIENVNVDDSSMNEALIRDESNGCKEIITVEALEKHQVECQFRFEKCPFTGCDKILRLKQIAEHKIDCKFSSKYCLHCDKEIPGQLDAHALVCPKVRIQCTQSESCKKSFPREQLRLHIDQDCKFTIVKCKYCCLNNSKNESIDFKRFELADHYEKVNHSFEMDKVINNQQLELVECKNQIYQINNKYEKLLERVIKLEQLSMDASNKLSLLPRFKNSIIFATFSTHKLKRVNEGISTVPLDVGNNKFKLTLYPNGYDESNKGNISAYLYRVSINEPAVKVSFTFVFNNQDSRKNRTYRIQEYTFNGGATSGWGYPKTLKTVDVDSANGWLTDEDKLVIGLRIQVLP
The following text describes a protein:
Function:
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MITVNTEESGTREEVKMSAPRRNIKFLMFMIHVNYAIYGISSHLQGGAFPFVSKKLGVDPTTWGYLQTTIAVAQLAGCPIFGRFGDLYGGRAAMTLTFLGMMVESLLVAMAFSGGIPLLFISRAPMLFIHPMTAFQMVASDLSDEKTRADALAKLNIVSTVGRILGPTIAGWLVEHYGESFTCVAAASLSAVCVALVLVFIPVSTKQVNEEKVETSSQKKTSLFDYREILRLLRIPAVAELLGIKMFCSVAFFLLNSMMPIIQMEVFNMSPQEYGYFGTYLGIVYLICFSCVSPLTKRLSDINVMRFSEILVTIGDFGLALSNNYWQAGLAFLPRCFGDGILATMINSGLSKGVSAQDTGGVMGLSLSAGHVPHMITPPIAAYLFETFGYRSIGIGCFAINSAMTVYLLRRKDAPST
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Sequence:
MDFSDFLNEKLFVLDDTIKTSSVKGSTDLKLCLVSAISLTDFIKSSLGPKSGDKLIVDENGDIIVTNDGYSIIKYLSRSSKIESDNDNSGNNSYNIGNNINDNNNNNNNNNNNTSSNNQTFSNKSTIERKRFQSIIELLIDTCRTQERLYGDGTTSVLVLVGALCSNAMKLIYEKGIPPHKVVESFQKSLKIALKLLNNYYLPVKTTYDNSNTSIENNCNEITLEKVTQSSLLSKSISFYKKELTNISIQSVNLIFDYCKSIYNNNKIIDSNNNNNINNDINKNNIKIDQKRIKIKCIEGSKLEDTKLIKGVLIKRFFSHKNMPKIIVNSNILVLSCPLEFPKPKTNFSITVNSLEEYESILKVKSQYYQNIIAIIEAIGVTNLVIVCQWGIDQEINQYLSNKKISAVCWVPGDDLERISSINNYIGHCERISEIVMGNDSSNRYIEFSGCTYSSTVTILVRGGSKEMCEETVQCLRDSIHIASGCLKNPKVVPSGGSTELFLYSQFQNQQFFNNSDNNKKEFSTIQIMAMRSWSESLLSIPITLLENGGYDCQDILMKLIKLHNETNINKYYGVDINNIESFDLYSCNQEKLLNENQSIIQDMKFKSWELLGLKKSILKLATETACMLLSIDSFISL
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MARQGAYSDAGYCSNGEKKSTSQVPQLGNAIFHDFLGIKTKDASVLLAAKTPDVSFSEASTPPSALASSSGGRGLISAASDLASENQVCDYLEGVPFYSPRNDISGPENGNRIAGIKRGNPDSAFMGPYRNQIPHILQNGAGGDRPRYNDNEVVYSMQPPRIASSSLTQHSLGTRFNPSVSKWERPIPSNMSSALNSSLGSQFVPRVHQIASNSSREFNVAPSNISQSAADEGSRTGMKNPGLLSSFNARHDQRHSSQMLQSCDKQKTKTESLAYKSSNPSSQQGLDSDNRQMTIFYGGQAHVFDDVHPNKADIIMALAGSNGGSWSTNLAPKLNITRIPSEQESAKDYHGKLYHSLISTSRGVGDTPISTQAAVGDHPRSVAAEETQKAVRAADLNAEQ
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MAICDLAWSETYFSFMFERGRSVVSLKFNHCFLSSVVFLKNCSSACEMIDKDMNSACMRGGSVRTLNNYQQVMEPRSPHTAWQFGVSQIVKREPMDEDKNDSGVTSGSDFHSSSPSSDTSQDLQHSYQSPQTQPARFYSTPIVPHFAYNHNPLTPPNSEPLVSPKSEKEEKDMETTLTPCASPNRKPDDNQDHLRRLEMSLEKSGLFSSKTSEHSVDELSGKSDNDAEEYDEQSLRVPKVNSHGKIKTFKCKQCDFVAITKLEQWNHSKVHIREDKRLTCPKCPFITEYKHHLEYHLRNHAGSKPFQCNKCDYTCVNKSMLNSHMKSHSNVYRYSCRDCSYATKYCHSLKIHLRRYGHTPNVVLDEEGNPCPDIIIDVHGTRRGPKIKTQPKAEEAKPETLPFLNLQQQLPFPGYPFFGGFPNAQLLQQLIRERQLAAGGSQEESRVLDLSKPGCSYTGEQKSRRKGPAFKVDPTQVESEEEDEETSTTVFSNVEVVQEEAKKEESDSNNNNNKEEGNSCQYCNIAFGDAVLYTIHMGYHGFHNPFTCNMCGVECSDKVSFFLHIARVSHS
The following text describes a protein:
Function:
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Sequence:
MSEQTGLALPQTMDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQTCLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEGA
The following text describes a protein:
Function:
Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme.
Domain:
Gln-155 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
Sequence:
MSRPKNQNYKGHGLQKGKEREQRASIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMGEHVRISHFRNHYELTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWKKGTAGKKLTSLEAQPARNTVNPSGSHDTRSSDDQKDEIPVENYVAQRYIENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDQYVHLTNVAVQKTSPDYHPKKGCKWMLQRFRQYLASKHGPEAVETLFSDMDNIFIRSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHIVDMEARLTGREKRVGGFDLMWNDGPVSREEGGPDLSGMGNFVTNTHLGCVNDRKEQLRQLFRSLQGQKKTPN
The following text describes a protein:
Function:
Scaffold protein required to form the phloem filament matrix in sieve elements.
Sequence:
MESLIKSQHAQQLAGHKNTTGKTPSMEMIPATGLAMSSDESMMLKLIQQTHSPDAREVQVRGLLSLVEDILDRATLDSEDTNASMLPLPTEDKLMQSSMMSVLDSVSYAIDRVACEIAYKSLTGSDSHEITMSVFEHLSSFQWDGKLVLTLAAFALNYGEFWLLVQFYSKNQLAKSLAMLKLVPVQNRVTLESVSQGLNDLIREMKSVTACVVELSELPDRYITPDVPQLSRILSTIPIAVYWTIRSVIACISQINMITAMGHEMMNTQMDLWETSMLANKLKNIHDHLAETLRLCYRHIEKQRSSESLKVLHSLFDTTHIDNMKILTALVHPKPHITPLQDGLTKRKVHLDVLRRKTVLLLISDLNILQDELSIFEQIYTESRRNLVGVDGKSHMPYEVVWVPVVDPIEDFERSPILQKKFEDLRDPMPWYSVDSPKLIERHVVEFMRGRWHFMNKPILVVIDPQGNEASLNALHMIWIWGTEAFPFTRSREEELWRRETFSLNLIVDGIDSVIFNWIKPDNYIFLYGGDDLDWIRRFTMAAKATAKDSNVNLEMAYVGKRNHSHREQIRRISEVIRSENLSHSWAEPALMWFFWTRLESMLYSKIQLGKADDHDDVMQGIKKILSYDKLGGWALLSKGPEIVMIAHGAIERTMSVYDRTWKTHVPTKGYTKAMSDHHHDEVLRETGKPCGHFDFHITARSGRIPEKMNCFECQRPMEKYMSFSCCHDEKLHEDENYNF
The following text describes a protein:
Function:
Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2 (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Domain:
The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro; The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization.
Sequence:
MAAASVSAASDSQFSSVLAEPSRSNGNMVHHSSSPYVLYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIRAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELASQLVAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQSGIEANRLIFEDRNTSCVSTSTRKIKKKKSKPPEKKGFRNNFGAQPHYRLCLGDMPFVAGTSTSPSHAVVANVQHVLHLMKHHSRALCNDRVVNSVPLAKQACSRGSKSKKSVAPPSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQESPSEELKDNLECELEALVRRMEAKANQITKVRKYQAQLEKQSTDKQKELKGNKKTLDEEGNSSSRSSVITRTTSKKDFTKQRPGEKSRKNLQLLKDMQTLQNSLQSSNVCWDY
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTSSAGQGGGALSTRGGAATKRMKWAVELSLGNSRSRSDRQGKDGDVMYPVGYSDKPVPDTSVQEADRNLVEKRCWDVALGPLKQIPMNLFIMYMSGNTISIFPIMMVCMMAWRPIQALMSMSATFKLLESSSQQWLQGLVYLIGNLLGSALAIYKCQSMGLLPTHSSDWLAFIEPPQRLEIMGGGMVM