lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Monooxygenase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2). Within the pathway, the monooxygenase af470 catalyzes the oxidative cleavage of prefumagillin to yield the final compound of the pathway, fumagillin. The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520. The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps. 5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene. The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin. Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (Probable).
Sequence:
MDQSMKPLLSPTERPRRHLTASVISFFLPNQFRLSTILCIGALLQTILCAVLPLRYAAVPCVTVLLISVLTTIQECFQPNTNSFMADVIRGRTTAQIPGKDGTHGREPGKGSVVVFHLGIQYNHPLGVFAPHMREISNRFLAMQQDILRRKDELGLLAVQNWRGSERDSGNTTLIKYFFKDVESIHKFAHEPLHKETWTYYNQHHPGHVGIFHETFITKDGGYESMYVNCHPILLGRGEVKVNNRKDGTEEWVGTLVSADTPGLKSFKARLGRDD
The following text describes a protein:
Function:
Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MASMEEDFPRGGTERKKPTDLIPHEVDNLFDTPAKVVKKKKKSVKQDEAPKSKKQKVDEENIKLNTTTTVQILHLRDLTVGTLMLGCVKEVSDFEVVVGLPSGLVGYLPICNICDAYTNILNDKLDTDDGLEEVVPLSKLFTPGMLIRCVVSSLDSAKEGHISLKLSINPKDVNKALNSVALKPAMTLSGCVESVEDHGYLVDIGIGGTKAFLPKKSTSSKQDLYVGQYVLVLIEDVKDSGRVVRLSQNPQALVKACAETKQGWTLDNLLPGLLIHGCVKRVTPHGLIVTFLSSFTGVVDFLHLDEDKESTYSKGQEILARILYVQPSTRQVGLSLRSHLLPPGGAVLDLHFSERVGEVVQGCQMTSLHHYSGALMKMLDGSRAFVHRNLLKEPKEELDTNHLMSQTQHILRIINYSPIEQIYQATLRWSSIETPFFSCQDIKVGQIVEGTVTDLQKHGVYVRIGEHIRGMIPRIHLADVTLKNPEKKFYPGLKVKCRVLSVEAQKKLLILTRKKALVESTLPIFQSYSDARPGRISHGFVVCIKEFGCIVRFYEDVKGLVPMQELTTETVTNPEELFFVGQVVKVKVLKCDEEKKMLRLSFKSVTEEDVREEQIAKFDFIVGKMVDARVCRKVLNGLEVSIIPEEVQAFLPTTHLSDHVTNCLPLWMALEEGDTICNLMCLTNYKKKGIVLTKKPHLKAYIEDGAVPKNFSELQVGMQMVGWVKNIMPYGVFISFPYGVFGLAPIANMGDQFIKETSGIFDIDQTVVAKVTNLDEEKQGFLVSLKLSELSLSENEFHTRLIQGLKERRNISEMRAGRGDSDVLWKLSALTVGDQMKMIVGDTTEDGSVMLTSDQLSGVTVLASKYHKEGVNLTPGCKLNAVILHIDFVKSQVHVSLRPKLNIKKEELEKDARFTAKVQFADKDFAVVSLATTSDLTFFPTRPHLNSIFDSKKFSVGSCLDVKVDDPNCEDLAGFPLISYQSSNAKHEQHKPNEERLGELMKVTVKKLKALCVLVNLPSGNTGRVHVSQILEFPDIGSCPTSVLKVGMEMEARVIGGRAVRAHNFLAISHPDYNISIPELSFLESKLKVSDMVNKLEKYKPGDDIICFPSKYIKKEQLLEVHVKPDIMGAVPLLAMCNKLGLSKHPQRLFKPGQALSAKVVSVDPKKPIQFSLSLTGTHKLEPGMNTLAMVQKIQPHKGLMLALPYENTGLAHLTDLSDSYTEKPLESYKEGQIIRCHVIEQKIKEFNVSLRPSRLNKDKHDIVEDPEIQSIADIKEGQSIRGYVSSVNDQGIFLRLSRTITGRVLFQNATKYYMNDPKVLIKHVGQNALVAAKVLSVDSENLHVNLSLLSKDTGKPDLLPESLELPLRLTGEEKEKHDKKAAVKRKRTLSESQQQDNENTEQKTKRIKVDEECRLVEEPREQKETLKEKKKKKKSKKEDSDSGVEVFFRETDETVSDKKSGKVKVKCKEQEPNRLQVTSSFPWESTLGSLTPFAPADDNQNSSEDEEEVKSKPAKKSRKELKQEQQNTEQKPSKLEAELMDTSVRPDNSTAFERLLLSSPDSSLLWLQYMAFHLQATQIEQARAVAERALKTISFREEQEKLNIWVAMLNLENMYGTPDSLQKVFERAIQYCEPLLVYQQLADIYAKSEKIKEAESLYKSMVKRFRQDKAVYLSYGTFLLRQRQSDAANALLQRALQSLSSKEHVDLIARFARLEFQFGNSEKAKSMFDKVLTTYPKRTDLWSVFIDLMVKHGSQKEVRELFDRVIHLSVSVKKIKFFFKRYLEYEKKNGTPETIQVVKQKALEYVESKGAEATS
The following text describes a protein:
Function:
Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Involved in chitin degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNWDGLYASAFERIRDNIGKVGNVLLAYNTNIDAIKYLEREDLERRIGAAGREEVLPYSEKLPKRIESVPQLLGSILWSIRRGKAAELFVESCSTRFYMRRWGWDELRMGGQVGIMANLLGGVYGVPVIAHVPQLSRLQAELFKDGPIYVPKVEGGKLKLVHPKEFKADEENCIHYIYEFPRGFRVFDFEAPRENRFIGSADDYNTNVVIRPEFEEHFGEIAEKTELAIISGLQALTEGNYREPFETIKEHLDVLEGKGIPAHLEFAFTPDETVRKEILGVLGKFWSVGLNEVELASIMDVMGEKTLAEKLLAHDPVDPIVVTKAMLKLAEKTGVRRIHFHTYGYYLALTDYRGEFVRDALLFAALAAAAKAKLGDVRNIDDVVKAMDVPVNEKAKGVEEALTKEYGMENGIAEVNGYQLAFIPTKIVAKPKSTVGIGDTISSSAFVGEFALR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MASNILFEDRFVISSVDNSKFEKVSRIKAKSTGYDAELILDVHSELFKVEEKKAIYLALQDKLLNRNDEKGWEQNENVPLNNIEYIMSGRIFKFEELSSERRTVYASFGGLMMALTTDKQFIGDLEIDMKIYLLTKNIDIERTRE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MENATFQGIQASQLEYHLNLVKEKYRNEFLTPLNENLENSLEEADCQLENYKSLASDYNEIINDARRENLRRQREIKKQGRNKITHLNSKIYQEESNLQQVEVKNEQIQMRLKQVPTEIQEEKEQISSVREAAKITNVEFYAKAVKMFQERLGLKIEKTKDKKMKFIYTRIDPNDDQKEFCVSFGIDSLSKQYYVVESVPSVSGLQSLIDQINRSGNLRIFVKGVRSLFQEYVNNPVDRPQQL
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MAVLNRTTSSSIIYTVLSLMLLSTKNVASFSGHYQPTSTTQWQRNSKSPAEVDVSVGSTTSSSPFVVALTREEGKNDKLRKALLSNEHIQQLSQSSGVAVDIHEIPCIEHADGPDTDKLVPTLASTQFDYVAITSPEAAKVLVNAWIEAGRPQLGKVAAVGKATQESLKEFGIEVAFVPSKATAATLVKELPLSDAATKEGRSSTLFYPASNKAADTLQNGLEERGFDVMRLNTYDTVPASWDEEQTLLAQSANVACFASPSAVKAWLKNTDGMNKPARAKAACIGETSAEACRKNQWDESDIFYPEKPGVDGWAVSVADALDYLSSITE
The following text describes a protein:
Function:
Contributes to proper distribution and/or efficient assembly of nuclear pores. Required for normal pore density in the daughter nucleus during telophase.
Miscellaneous:
MISCELLANEOUS: Present with 1680 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus, nuclear pore complex.
Sequence:
MSSRPANNQGPPNLPARDKSLVQRFMAVAKSLQFAWFTGHSVVLISSILYLLKMSEFYYRSAYLGVIESFGIIIYQQFFTRNEPLQTQDAAATKASIKSRVAGLLKSEDVLYLVLANFWLFTPRFSFSLIPFFAFAVFHVLIYVEKVLLPKVFHLSSKDSSKILSFIDKFVVQYNDLCMHWVGTAELLIFILVLFRAILCFQRSWIILVVYAIFIKLRYENSKYMKAAFAQWRVRMDGIISHPSIPPFVKRAYNAIKMSLIRLSEYRLSGAPQVTKKQN
The following text describes a protein:
Function:
Guanyl-nucleotide exchange factor for ypt2. Catalyzing the dissociation of GDP from ypt2 and promotes the binding of GTP (By similarity).
Sequence:
MPDVSNVRVKPNQHPYEKEVNGKLMSQEEILSQKLVAAIERQAALDDKYATEVHRNEALSERIRELEAKLSAKKSFDEELVKFHNLEEKLQLTETKCRNAESEKSRVENELEDLTSSLFEEANRMVANARKETVASEKRVNQLKKQLVDAETLLSSTQHQLTELKDVMHSMSDSHEQNNALHPPLSRTTSFVADNVSVGSFASSTSGLDILTGTSARESLDAKEISSDKHLNISGERPATFPNPTFIEGSDERRSASSLGHRTNNNQNQLIRFSTQIRSSSTSPPRSPLIISDSPSSSIIHNPHPTHPSASAMNYMNPCFLEFHAFFNYPMKFARSRSAYSTSANYSNTPPRNTVTPSTARSSTLSQNPSSSSNSIPLISRNLRDFSFFKRCLEEDIEPTLRLDHASGLSWLTRRSVFTAILESSLIINPLHSTSLLSSQPCSLCGFNRTQPLRQFEFRSRPDSTSHASCTYCVARLRSVCNFVAFLHQICKGVWSSCSLEKAWDECLKKREAMFLSRVGLAKELEG
The following text describes a protein:
Function:
Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.
Miscellaneous:
MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATMVAQKLSHLLPSLRQVHPEPQPSVHPEPVFTVDRAEVPPLFWKPYIYVGYRPLHQTWRFYFRTLFQQHNEAVNVWTHLLAALVLLLRLAIFVGTVDFWGDPHALPLFIIVLASFTYLSLSALAHLLQAKSEFWHYSFFFLDYVGVAVYQFGSALAHFYYAIEPAWHAQVQTIFLPMAAFLAWLSCTGSCYNKYIQKPGLLGRTCQEVPSALAYALDISPVAHRILASPEPATDDPALLYHKCQVVFFLLAAAFFSAFMPERWFPGSCHIFGQGHQLFHVFLVLCTLAQLEAVALDYEARRPIYEPLHTRWPHNFSGLFLLTVGSSILTAFLLSQLVRRKLDLDRKTQ
The following text describes a protein:
Function:
Catalytic component of the nem1-spo7 complex which acts as a phosphatase and may be required for proper nuclear membrane morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MNSIARLSDEINKAILATPLDDDEADKEKLANARGRASSATLRHYNRRRSSYSASSLSSLSSKPTEKEVPTRNEKPKHANIMRVVVYWIRVFLKRIYTFFVHSARVFLYHFLNEEKEFTLASFFWGLCRFVFFPVLLSYKRREMLPPQPSVRRPRFYSSYSYPSSHQDPAYSSFKRHRSSNSYSSSSNGNHVRFQPSIAEEEISFNSFSNSLNSEEDVCVSPMKPKEVSLMGKANSNRSGHSHQPQSTQFSPPANDNISKLPSSFTIVNDPLKSPSSSRLRIRNITLCADKIPRPLLNSKLPRKTLVLDLDETLIHSVSRGSRTTSGQPIEVHVPGEHPILYYIHKRPHLDYFLSNVSQWFRLILFTASVQPYADPIIDYLERDKKIFAKRYYRQHCALVDSSFVKDISICNIHLSRIMIIDNSPASYNAHKENAIPIEGWISDPSDVDLLNLLSFLHALQYVHDVRDLLGLRLAK
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MVKLPSLKFLRRSTDETPNVSETASHSTVLDVGAEKLGKTYARALLAATQADGSTDAVVSDLNAICDEALLHNPKLQLAFQSPQIDADEKCRVVDRLFGGNSHPTLIKLMKVMAKRGRLGYLVAVRDAAVDLFDEAAGRVVAEVRTAVPMTEQLRGEVTQQLSSRFGKTVRLRESVDTELIGGMVIRVGDTVFDSSVASRLDKLGKSAAAGFARQLIEQSDRFSSSS
The following text describes a protein:
Function:
Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDRPGFTASLVAGGVAGVSVDLILFPLDTIKTRLQSPQGFYKAGGFYGVYAGVPSTAIGSFPNAAAFFVTYEYVKWILHTDSSSYLMPVTHMLAASVGEVVACLIRVPSEVVKQRAQVSASSGTFHIFSNILCQEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDRVVDSWQAAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTASGNILSALHAVWRTQGLSGLFAGVFPRMAAISLGGFIFLGVYDQTRSFLLELGRESP
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MIEAILSGYEATQEEQSNVCAHNLHNGSLLSTFRQSSPYPNATCISRSYLLSAQKNKPQLNIHAFGKENLDQRIILPETVECLKCSPCGSWLVAGTKSGQLYLWSMLSGALLHFFRAHYEALTHLDFTDDGMILLSGSKDGEVNAWTMASLVDKSNQNNVGVNSSIKPYRKFSGHTRDITGLYCGKGPAVASRVFTTSRDNTVKIWDMSSGLLLTTIALPVSPICFCCDPAERVLYLGYEKGFITVPLFVNPNTKKDTSTENSAPYALGGNGKIVDGVEGEPFPSVQHTSAIQVLTLSFDGSLLISGDAEGTVLVWDVVSKQVLRKIVTFPKPVTFLQTTTESMQLPANLTPFPMLKRMVTEEGILSDLSVAIEDNGVEELMQLPDILEVGKEILSESTESGWRAKAEALELELKEARSLFLELKQVHQGLWEKYLKM
The following text describes a protein:
Function:
Acetylates the N-terminal alanine of ribosomal protein bS18.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKVREMEREDVERVYEINRESFTTDAWSRFSFEKDFENKFSRRFVLEEDGKVVGYVIFWVVKEEATIMTFAIAPGYRGKGYGEKLLREAISRLGDKVKRVVLDVRKSNLRAINLYKKLGFKVVTERKGYYSDGENALLMELKISRPSEAELSR
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEKIGVFFTFGKFLALTPSHLYNRKRSFGQKLYFFVVIVLYTASAISSQYFRDYSRSKVCEMALKYFKDIIRHCHTFYILGPLATTKRHYWFKMIKIFRKNNHISGANPIFFYYFLAWHCLFVTIIVIWIRLCFLLLGLKFLEVYVVEFFQLYSHLFFMFFACVLLDMFRKFYESRKLKLDQMIRFRPTNFEKYKIDIFRLTSGIGIFNKIFGPLLILNILYICDMFLLYVNGLMKTKRHTISPDLYILLLSYRIGVIVFYWLHVAVMAVLADAISQQYDEIVHLANKLQLICTKMDRKIVEDFVEFIGKNRPEIDVAEFFILKRSTIFNILNFVIYFLIVIVQFK
The following text describes a protein:
Function:
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins.
Subcellular Localization:
Nucleus matrix.
Sequence:
MSKSFQQSSLGRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGRMNQGTARLASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHRGDADQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGRDGRSATREPPYRVPRDDWEEKRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMDYEDDRLRDGERCRDDSFFGETSHNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIYPEWNPDNDTGHTMGDPFMLQQSTNPAPGILGPPPPSFHLGGPAVGPRGNLGAGNGNLQGPRHMQKGRVETSRVVHIMDFQRGKNLRYQLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKRIKKPEGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDKKSKIDGSQKTESTTEGKEQEEKSGEDGEKDAKDDQAEQEPNMLLESEDELLVDEEEAAALLESGSSVGDETDLANLGDVASEGKKEPSDKAVKKDGNASASAAAKKKLKKRRFPGSMEGFVTLDEVDKIEELDQENEAALENGIKNEENTEPGAESAENADDPSKDPSENADGQSDENKEDYTIPDEYRIGPYQPNVPVGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAEERRQKKEA
The following text describes a protein:
Function:
Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGAIFGPLEGPSSLDAPSIHPLVCPLCHVQYERPCLLDCFHDFCAGCLRGRATDGRLTCPLCQHQTVLKGPSGLPPVDRLLQFLVDSSGDGVEAVRCANCDLECSEQDVETTYFCNTCGQPLCARCRDETHRARMFARHDIVALGQRSRDVPQKCTLHAEPYLLFSTDKKLLLCIRCFRDMQRESRAHCVDLESAYVQGCERLEQAVLVSAGAWREVRHSAAEEEDAIHALFGSMQDRLAERKALLLQAVQSQYEEKDKAFKEQLSHLATLLPTLQVHLVICSSFLSLANKAEFLDLGYELMERLQGIVTRPHHLRPVQSSKIASDHRAEFARCLEPLLLLGPRRVAAAASGANTLAGGLGPKALTGPHCPSPVGKMSGSPVQKPTLHRSISTKVLLAEGENTPFTEHCRHYEDSYRHLQAEMQSLKDQVQELHRDLTKHHSLIKAEIMGDVLRKSLQLDVQIASEHASLEGMRVVFQEIWEEAYQRVANEQEIYEAQLHDLLQLRQENAYLTTITKQITPYVRSIAKVKERLEPRFQAPVDEQSESLQNTHDDSRNSAASARNNPGSVPEKREKTSDPKGNSWAPNGLSEEPLLKNMDHHRSKQKNGGDVPTWREHTT
The following text describes a protein:
Function:
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (By similarity). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (By similarity). However, it does not execute the GAP activity, which is mediated by NPRL2 (By similarity).
Subcellular Localization:
Lysosome membrane. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent.
Domain:
The DEP domain mediates the interaction with KLHL22.
Sequence:
MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEETRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSIDEFPEINRASIQEDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAGGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSVPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKSASEKTKNGRDTSLGTPKESENTLPIQVDYDAYDAQVFRLPGPSRAQRLATCRSVREQENHSRKSASSCDVSSSPSLPSRALPTEEVRSQASDDSSLGKSTNILMIPNPHLHQYEVSSSLGYTSTRDVLENMIEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSRQRDPTHSSAELLELAYHEAAGRHSTSRQPGDSMSLNFSGTEELSVSLLSNSSTGVNPRTQNKDSLEDSVSTSPDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADMDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNTTVPPPLSSSPLYSRGLVSRNRPEEEGQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVDFCHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEVHCDIYGDKPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMIRKGTAMKGLQMTGPISAHSLEAAGPPVGKKGTSALSALLEMEASQKSLGEQQTTVHGKSSTQPAENSSVAMTPTYVDSPRKDGAFFMEFVRSPRTASSAFYPQASVDQTAPLVLDSTSLGVSTGQPMDRGNNQTFGNSQNIEQAFPSANSGDYSSQQHVASSLTSSSTLVEILEAMKHPSTGVQLLSEQKGLSPCCFISAEVVHWLMNNVEGVQTQAMGIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVMDKEPERVAMQQPSAPWYTAGADDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTATVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNLSCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSVSAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTNCLEKMHASAP
The following text describes a protein:
Function:
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity).
Subcellular Localization:
Endoplasmic reticulum. Secreted, extracellular space, extracellular matrix. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG).
Sequence:
MAVSERRLLAAMLAVAAAAALRVAAESEPGWDVAAPDLLYAEGTAAYSRGDWPGVVLNMERALRSRAALRALRLRCRTRCATELPWAPDLDLGPDPSLSQDPGAAALHDLRFFGAVLRRAACLRRCLGPPSAHLLSEELDLEFNKRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMRQNLDYYQTMSGVKEADFRDLEAKPHMHEFRLGVRLYSEEKPQEAVPHLEAALQEYFVADEECRALCEGPYDYDGYNYLDYSADLFQAITDHYVQVLNCKQNCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAIECAKTYLLFFPNDEVMHQNLAYYTAMLGEEEASSISPRENAEEYRRRSLLEKELLFFAYDIFGIPFVDPDSWTPEEVIPKRLQEKQKSERETAVRISQEIGNLMKEIETLVEEKTKESLDVSRLTREGGPLLYEGISLTMNSKVLNGSQRVVMDGVISDDECQELQRLTNAAATSGDGYRGQTSPHTPNEKFYGVTVLKALKLGQEGKVPLQSARMYYNVTEKVRRVMESYFRLDTPLYFSYSHLVCRTAIEESQAERKDSSHPVHVDNCILNAEALMCIKEPPAYTFRDYSAILYLNGDFDGGNFYFTELDAKTVTAEVQPQCGRAVGFSSGTENPHGVKAVTRGQRCAIALWFTLDPRHSERDRVQADDLVKMLFSPEEVDLPQEQPLPDQQGSPEPGEESLSDRGSLHKDEL
The following text describes a protein:
Function:
S-acyltransferase involved in protein lipid modification.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MARRHGWQLPAHTFQVVAITVFFLLTVAYYAFFAPFLGNKLYEYIAIGVYSFLAFSVLVLYIRCTGIDPADPGIFVKADNTPAHKSQNSNYVPENASAIDGGPYIRHGSGCCSAIGRFICGCLVIQDCRRDTQQEQSNEQEEALFCSLCNAEVRMFSKHCRSCGKCVDGFDHHCRWLNNCVGQKNYISFVCLMAASFFWLIAEFGVGVTVFVRCFVDQKAMEHLITEKLGLGFSRPPFAAVVVVCTTLSLLALIPLGELFFFHMILIRKGITTYEYVVALRAQTEPLGTSVDELDQTSQYPSPASSAVTATSARSSLGLSIQYRGASLCTPPNIFVDQQDDVIQHLEPGPVRSTIDPDSLSQKKPPQRQQVRINPWKLAKLDSKEASKAAAKARASSSVLLPVSSRQNPYKTSSNVSGRSSPGRGKPADSESCSLSSPGLTRDHFNPMYMSSPANESPLNEEESRNAVVAARRNLPSSDESSVVWDPEAGRFVSLSRIPGTDVGGPLGNECLNTITSTGTDRSRRARGNPLTGYFQQVRSQRGDQLPVFMPTDSQLHRHLSTRFH
The following text describes a protein:
Function:
Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling.
Subcellular Localization:
Basolateral cell membrane.
Sequence:
MTAKRVDMAAPDNLLFLDSDAVNSSPASVPIEQNEPTHVLDNQTDDSLRSMPDPHTNTALESTGLMPVPCQDETLETHSQHNEGENESSLVSTQHMDHTRLTEMTINDEKSNNWDFDISGVKENDNSTNLNPDLIHHAGTDSVMERNLNDKQTDLNHKDETFGSLMSSEVLLLKENRQQEMSQDTNLHQCSSSESTGIEYSQTANDAISDAMNSEQSPDQPFSIASNDTDKTTSECSVQTCWDTVESAATSKTQPELHDDVKDVMCESFTTSQTLNIDYLSTDISVCLADLPETDSLNILTPASTLLGILGKNNNVLKTADVPINDSEMVQSINKDLASPNADISKTVFTQMDQNLLHVTDHNVKVLESNRADTVVDQYVFSENIGQEVSQASSHDEDLNSSVQSHDQQLSTANSEIEETSSEFHTQTCQDIHEGVIIAEEAMNGHNTLPEMHDIADVTTSQTPIMKDPMIDEPSYLPDLHKADTPNVITTASTLSDTLETDDSIFETADVSVSDCELIQTVTLKTVTTYETLLMMHDVGEDLTCCDFTTSAIEEPETSHPLSLDDLHESNTPNIPPHASALLDSLGMNKNFLETADVPVSDCEVIQTVTFETVTTYETFPVMHDIAEDLTCCDFTTSETPKIEEPETSHSLSLDDLNEANTPNILPHASALLESLGMNNNFLEAADMPVSDREIIHPVNKDLDSSSVEICTVVLTQTDPKEVQDSDLDEKETESNRIDDSIDGMIDTKFSLDVSKLQPVCSNDLSGTVIHSESLFSQSIPDTPQIGEKYKNDLLQVISPPTPVTNEDLGNCSEEIDDACLKFTGTERDVEGDSELWLEPSQFLAGEEDEGAIFDKWGRSCSSSPPTTHPDNTKASDYTWRENISIDHNAEDWELTFPPVERWSSSDSWASALSDWFQAVNTYPEDSFKSASTGSKLGMAIQDNILEQRTSSDNANNDEQTCLSLNLMQPDEPGQALERGLVKSDNTNGTVFKQGDKERLASCLDMDKDTTTMESQMSLLETSTPESHKADNNAVMETFNASLTHEFNAKLHGSLDISGKLLSAKREGNVLVEVTGGKVSQLGLVFEEERQSIFTSPSSSAYTRDKNLTGCVSNEERCHSSDVHLCICPSQSDSHVSSKAGHAEGNGSFLHSNIGNCTVKPYVEENIPQFIMPFAPICTGNTFLHRSFLKEDRSQADLDLPDKKIINKINLKSNKKSSSSDDSSEDNFHTCPDQSLSSSSGDSDDPSITDSGRKPAYSDTCDIGKELSKLLLLTGEHFMVSEDKRIAYVTLDLDESQHFGRFSLPNCEKQSKPDNMPHKTSKTSSDGKMRSKHKEKPDDKQQHGIQASKKQDPQPQSQVKNEGAGCEDCPVAVIETIVITEKIIPKTQGKKKKKHVQHGTPKPENDAPTDVRSESRQKNVNGKAENLELKVASNSLNKPVAQPSGKTDITKKDSAQKVMSVRPKVEPSMAKMDPAGVNATQKSSPIKLKADTFNTAKMENKTCTTDSLSTCLPSMLNDDIKRRRIADDLSRAVPIRTRPQLPAIFRQARKDGEDVTRRAYSEVVKQKNSTPKEVVVPRVVSEIQADPVPADPQNISLWCQFSPIPPEATIKWTKEAAVLSEINKVEKEDGRFTLTIIKACSKDLGFYKCSLIVANISVSTSEYHLTSEVLMELVIPSHDQPAEPRVMEGDEENIQCSPLLFKEDFLSDQYFGKNQPASILTEKVHFGEGMHRKAFRTTLTEGNLPRFRPGHPCVLKVHNSISYGTKNNEELVQKNYSLAVEECHVQNTAREYIKAYNSVAKSAESFGDLPEIIPIYLVHRPSNDIPYATLEEELLGDFVKYSVKDGKEINLMRRDSEAGQKCCAFQHWVYTQTEGNLLVTDMQGVGMKLTDVGIATCKKGYKGFRGNCATSFIDQFKALHQCNRYCELLGLVSLQPKPKRTVAPPKPKTQPVPKKKTFGPVLNAKS
The following text describes a protein:
Function:
Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.
Subcellular Localization:
Nucleus.
Sequence:
MQQTRTEAVAGAFSRCLGFCGMRLGLLLLARHWCIAGVFPQKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSSIAHSSPSPPGSKSATPSPSSSTQEEESEVHFKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSPPVSMSPAPQPPVLPTPMALQVQLAMSPSPPGPQDFPHISEFPSSSGSCSPGPSNPTSSGDWDSSYPSGECGISTCSLLPRDKSLYLT
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.
Sequence:
GMADVYSQGMISVLDDLRRRKVLTDAEVLCTEDGARFSVHRALLHAACPLFRESPSALAAGVTAVAAAEDATSSPCAAYPVDNIRGPIMAALLQFVYTNKVALSSENVLDMLLAAQRFQVRCGRTLVKDLGLWSESAESDKVLCWAFCSFLLNFSLRSLNRTERSQLVSKMCQEFVRISFDDLKALLSSDELNLADEGKAFSAVIKWTEADVATRHRFLPSLLSAIRFGLCKVSFLQEEVFSHPLLDDVDCRAALEPVHGLLDQLELHEGPQNGRPMASKHAPTCSFFRDVLFVIGGWSNGSATNLVESYDCRANRWLIFPNDRDIMPRAYHGLVALDGLIYMIGGFDGSQCFNCVRCFNPVFPSRWTERACMHVARCYVSVAVLEGKIYALGGYDGDRRTNTAERYDPVINTWTLIAEMNDQRSDACATVVDNKVYIVGGFTGQQVLNTAEFYDPKVNVWTYIRAMTVPRSGVRVINYQDTVYVLGGFNGTNRLSTGRSAGHGTQSTCLFASHELKKRRMGRPHKKKRPPVKPFHPGTTTVPFVECYDAKLNSWRRVTDMNINRSALGACVAINLPNSKEF