lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
Sequence:
MPKARASPAGTAAEPPHPKRRRLPDDDANSMPRYSSPAEDMNRDEDTTEYPGRSRAHRPLARRDRLPTSPNRTRDASASRSRSRSGRSRTRSTSPRSDEDEQQRRYRSRSSTSSRESRSRTSSRSRSRSYSRSITRSRSPRSRSRTRSRSRSSSIRDRSRSVSPSRFQGRRPSKSHAEQLRPNYRPRLELSGHTAAISQVRISPDGKWIASASADGSVKIWDATTGNNLDTLIGHMAGVSCLAWAPDSNTLATGSDDKAIRLWDRVTASPAHACGDESNRGQGPREYIRGGSQLARTARGGRTGMGPLLGHHNYVYCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIGFCCDGTLVVSCSTDGLIRIWDTSTGQCLRTLVHEDNPAVTNVCFSPNGRFVLAFNLDNSIRLWDYVSGTVKKTYQGHKNSGFSIGGGFGVVTDNKDTQDDYRHGNIGKPFVVSASEDGDIVMWDVVTKQIVQRIEKAHEGVCFWVDVNGDTMVSSGQDCTIKVYKNVRRKKHDRRLKFDKPNGISAIDGTNGHGNGRGIEINEAMGDDDL
The following text describes a protein:
Function:
May phosphorylate a specific serine in the N-terminus of a myosin light chain.
Sequence:
MGHQISKEDNGEQSNSNNLKKERRYTTNSSNLHFLYQQEEGIGINYKTGSANNSLSNSTNSNNNNYNNTNSSNNNNNSGNNKKITESTSLEDFKQFSTTLSISSTTPPDTPIISYNNSNNNNNNNNNNKSNKAVHFTRTRSRSLNITNTSRNLKVTSSPIIDSQVCAPNNSYNSSIQSLNSLSSTNSLSINTNTNTSSSLSLSSNSSNNSLSTLTNTTTTTTTTTTTNTTQQQQPIKGRKSKSSNALFKSLRSSLTGSSSSNSNSGKKRSSSISSSTNSLDINSANNNNNNNNSLKVSSKKSSKGGSPNSSTESLQSLSTSASASSLTSTPPLPPKSNAFSKSQNSSASSLNKQVISSLPPLAPTSTLTTTTTNLEVSKESLKPSSTPIDNNSVADSSYNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNLLDRLTDQLHRDPFFYNTNTAYQEENIIVEEVVVKEEEKSLPPKKLPPPLPPKNFKQTTTTTATTTTTTTTTMNPPSPIIQNVNRNNSSSNNSSRHELLRKSSGILPPQTEPTYPSETSSKRSSVEIKYLEENHKYQIFDRLGSGTFSDVYLCINKENGKQYAMKIIDKSLVTMIAQHTDMKVETEVNILKQSFHPHVIQIIDHFESELYYYIVTELLQGGELLYQLEKNHPSTNENVSNYTEEHARKIIKQVIQAVGFLHSNKIVHRDLKPENILFRDKSLGSILKIIDFGLASYVDHDCNCNNNNDNNNNNNNNNNNNTNGEVIQPSSPPPTKLIDVCGTPEFQAPEMVKRLGYSYPVDIWSTGIILYILLCGHPPFQGKNNMIVMSLIIKGELNFDSSVGWDNVSESAKDLIRKMLNPDPEKRLTAQQVLLHEWITTSSDVNGSPQLGAPLFYKQLRRYNSQRHFEKIGDTLLKSQRFIYMSPEKDYLKRRSIQL
The following text describes a protein:
Function:
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Sequence:
MPNCFKFHTVIERHWQKPYPVLSFLLKPLSGLFAKIAAKRRTDFLSGKRQSEKLPVPVVVVGNIHAGGTGKTPIVAALVSGLQEKGVKVGIISRGYGRKSKAVHVLNAESRAEDAGDEPLLLFRKTGAPTAVGSSRAEAGRALLAAHPDIGLIVADDGLQHYALRRDVEIAVFPAADTGRTDLDLLPNGSLREPLLRLDSVDAVVVSGGKADALFRPSENMFHSRIEAGRIYRLNNPSEILDTGRLKNQTVVAVAGIAKPARFFDSLRNMGITVKRTVALPDHADISAADLPDADAVIITEKDAVKFSDGICTDNVWVLPVCAIIEPDLAAFVLERLEDVPKAV
The following text describes a protein:
Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) (By similarity). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Selectively binds the N-terminal tail of histone H3 mono-acetylated on 'Lys-15' via the C-terminal bromodomain. Involved in multiple stages of somatic gonad development; as part of the PBAF complex, required for normal development of somatic gonadal precursor cells (the multipotent progenitors that give rise to all somatic tissues of the adult reproductive system), as part of the BAF complex, involved in the formation or function of the differentiated distal tip cells of the somatic gonad. Influences vulval differentiation of P lineage cells, which may in part be mediated by its direct or indirect transcriptional regulation of let-23. Required during mitosis for asymmetric cell division of T blast cells.
Subcellular Localization:
Nucleus.
Domain:
The Bromo domain directly and selectively associates with the N-terminal tail of histone H3 mono-acetylated on 'Lys-15'.
Sequence:
MSGRPAFEQFTAQPPQPAGEVVAQQAGDGAQGQELTISKLENAITSMEEQGLQNDHRHAKAVLLKQKLQSGLPDAVPGQENGGNQQITPAQLNQLRAQVSAYRLLARNEQVPANLIADAVMLRPKVTTLLPEPYEYPGEAENGEKLPYDLMKIFNLHQIRCNRPTTISVPSGIDPVGMLKQRENMIQNRIGLRMKLLNNLPADIPDHMKLKAEIELRALRLVNLQTQVRSEVMACLKRDTTLETALNPYAYRRTKRQSLREARVTEKLEKQQKMEQERKRRQKHTDLMQAIIQHGKEFKEYHRNNLLKMAKSRKAVMTYHQNNERERKKDEIRNEKLRMQKLMQEDEEGYRALLDEKKDQRLVYLLQQTDEYVDSLCSLVRQHQNTEKKKKKEDKKIEKGNQMDEEARVHVRERSTGKALTGDQAPKTEEIEFWLETHPEYEIVPRDQLSDDEEEEEEEAPVEPEEEKDDQYAGMDEETKAKMILEKARNEEDEYDQKTKKQMADYYATAHKIKEKVVKQHTTMGGGDPNLLLKPYQIKGLEWMVSLYNNNLNGILADEMGLGKTIQTISLVTYLMEVKQNNGPYLVIVPLSTLSNWQNEFAKWAPSVTTIIYKGTKDARRRVEGQIRKGAFNVLMTTYEYVIKEKALLGKIRWKYMIIDEGHRLKNHNCKLTLMLNGFFHAQHRLLLTGTPLQNKLPELWALLNFLLPSIFSSCGTFEQWFNAPFATTGEKVELNQEETMLIIRRLHKVLRPFLLRRLKKEVESQLPDKTEYVIKCDQSALQKVIYRHMQKGLLLDAKMSSGARSLMNTVVHLRKLCNHPFLFPNIEDSCRAYWKVNEVNGTDLMRVAGKLELLDRILPKLKATGHRILMFFQMTSMMNIFEDFLNFRRYTYLRLDGSTKPDERGDLLTQFNAPNSDLFLFMLSTRAGGLGLNLQTADTVIIFDSDWNPHQDMQAQDRAHRIGQKKEVRVLRLITANSVEEKILAAARYKLNVDEKVIQAGKFDQRSTGAERKQMLEQIIQADGEEEEEEEVPDDETVNQMVARSEEEFNIFQSMDIDRRREEANQLHRKPRLLEEHEIPDDILKLSFDYEEMERAREEGREVVDQTPNQRRRRREVDYSSDLLSDEQFMKQVEEVEDENNQAVAERKKQRKRKMAGLDENDDSMDDVVLQHKKKKTDPELAEKINEMLDVILEYKNEDGELIADVFQTLPTRKELPDYYQVISKPMDFDRINKKIETGRYTVMEELNDDMNLLVNNAQTYNEEGSEIYVSSETIGKLWKEQYDKFMNPPKPVEEPVKKKEPSTPSTSSSRPSTSGTPSVSDLQRTQQATAQQMLMLMTHMQSLPPAQAQQFQQALMTQTGGNQALMLQYMQSAMLAQRAQASTKVTPKKDEKKETSSSVKTEEAKKDDEPSTSSASAPPPKKKKESEDSEDPMEEDEEEEIIGQKKEPASSRRKSRPTRRFSNEDEEEEDDE
The following text describes a protein:
Function:
Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.
Miscellaneous:
MISCELLANEOUS: Present with 2540 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Trans-Golgi network location requires interaction with CHS5 and with myristoylated GTP-bound ARF1 for the recruitment to the membranes.
Sequence:
MSFLWGSTKSKKGKNKKAAGSLPSGVVPQQRVKPTRKNVPIDYPRTLEKVHGESLIFRTSLLSELVSTGKSGIGPPDLIHCTELDKFHDEKIGEFFYITGIDASSVSMPIAFLKLIKWNDGKKLKSASLKNDDITTYCTFNIFQKLDIRLRYESEDVYQVNIVDCLNGNNEIPLSDLIWEETFVSCCIRSVIINSDFERKIPGLVELPFVFENRCASDYKRVIDSLCKFLPRFLECGWDSTKSVYATILNNYLTESLLVFLSITPEFITDYAIQVLDNLMTNDPSNSRYYAIVIISIMERSNDRDVEMIKRIHEILDLLLPVLYGLPSDEPYISDLINCITDVLSIQARFLLNNNDYELSLSISTLATNLSSDNFESWYLLSKGYIFSQQYDKALLSINSMPCLAEYDIVKQAQINAFKFYMNYYKAPLCHSREHCTMTSHELNHLMNIMHYENELELKTIIFGRTVMPNESKYGCIEEIWNKSCLELGPICGPQSDNLINFVSQQEVNTVGDMLLLKRSKETRQESWFIKQVRLLLMELVARIGWNALLQLRSDVFVMESKFKMIESSDKLSTELRQKRLCQRWFDAMFLDVYEDLSISTSSQENKATAKYSGLEWELLGLTLLRVSDLPDAVACLRTSILARFDPISCHHLLNFYLTMDFNDEFMRRFDVDIILDLLVKLISFRIRFYDRFQIFSLQVLRKLEGQLGSEIIKNKIINSPYGQAGITSVIDYMLECLSKNRNEACLAYERPLPDLPSTIKPLAD
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSVRDIYDNENDDVNTSDEESIDTLGNIPLEWYNELEHQGYDHSGKPLPKPTKGRLDSIDQFLAMTDDPNYYKTVYDEYGNATVLNADDIRLVNAIISNKSDAQLEKDFPAVSYAYDDWMIPLNDYTPPKQRFIPSQKEHIRIKKLAAKLRKQFITLPQNVTKKARVKDIWGAGVHKKKYHLPLPPVKLPGNSASYHPAPEYKNENNTNYDRLMDIPQYSNLLNDVYSRCLQLYVAPRRLVKVPEHRDPLKELILPPLEELRPFPSNRNGVVKVKEVMRCIVVDPSGEYVASGGDDGSILITEALTGMEVKQINFPEAIRDIQWGKDDVLFIAVGEFVYGMKLDIRDVDSDYSIYELESVKVEVFENKTSFITPNEELKKEGIILAIHHPHLVKKLSLHHKGSYLACVFGTSSNSYCVIHHLPTKRSQNPAKNLKGFIQSCVFHPLKPMIAIATLSKIVIIDLQKGVTQKRLNVPSKSITDIVFHPCGDHLIACSFDKKCIWYDLQAGLDPFKVLRLHTAAVRAVDVHKILPLFATIGDDAEIQIMHGAASSDVTVDPILIPIVKLGGHEKKGQLGGTDIAFHPFLPWIYSTGADGTIQWYSDWF
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, including leaves shape, pedicule elongation, inflorescence organization and fruit maturation, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MEMKRVMMSSAERSKEKKRSISRRLGKYMKEQKGRIYIIRRCMVMLLCSHD
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MVILTARTVFPSTKSPIARRTSGWIHRSTCLPTRTRLVHQPAALSRFLDDLSAHSDQTAEQQDVDLYQNESDGVSRRSNASEYGSTRQSIIKLPTELVTGVQELIQSVSHRSTIRTNALGLYGKYRLTSSKESLNMSNNDLMDTFFSEKTTEDGKKFVKPKLRTTYDHLTSISFAAGAMPSAYGATLKVLLELKRRLNSDRIRRSLESEWTPKTLVDYGSGTGSALWAALEVWPDSLKEYTGLDKSSSMIWLNETLLKKRSNRPFLGQEASDLKASFRRITISPTQAERLKHATTTSTDWLNQIEKEEAKEKRPEIELEPSKFDWTGDSDGLLAIMSFTLSDLPNQAARREAIEGMWNSGAETMVIIDRGTPAGFQVVADARQQLLMLGRRQLRRARYEREVAISSENNEDEYPDNSAALGSWVLAPCPHDKPCPLHLSDNPKHFCHFSQRIERPKFLKDTKHTTRHEEDAKFSYVVIRRGQRPPSASLSSDLAGSSRETVPKPADDDNGNSSSGAALEWPRIILPPHKCKGHVIFDVCAVSGEIERLTVPRSQGKQAYYDARKTFWGDSWPHGSKNPAIVKDLQGRNGNRGDRRRKKKELNVEFDD
The following text describes a protein:
Function:
Synthesizes cyclic GMP (cGMP) from GTP (By similarity). Influences aerotaxis responses, aggregation and bordering behaviors (gathering around the edge of a bacterial lawn) in combination with other soluble guanylate cyclases.
Miscellaneous:
MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
Subcellular Localization:
Cytoplasm.
Sequence:
MFGFIHESIRQLVIRNYGEDTWTQVLERSGFESGKENIMNHYYSDTDTYVLVDSVSLVLKVTKDQVWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEETPDGTLLLHYFTGRPGLYHIVKGVVKEVAKRVFDLDITLVVQGRTQRSVHMNNGERVEEHVVFLINNLSEPRRDSEGSEVSLLTSTNANFPTIVDDTLGISLDDFSKALPYHFVIDESCKLVQCGSELHNHIPNELLQPGTPILRIFEINRPQIPLDFENICNFINAVFVLQVKTSPLKKKHMDAMSQEELKQEMETLDEDATNELTQGHHLKLKGQMMLLASKKHIIYLCSPYVTSINELMQYGMRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQLETMTRELELERQKTDSILKDMLPRRIAQQLLSGEHIEACEHEATVMFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVETVSDSYMAVSGIPDYTPEHAENMCHVALGMMWEARSVIDPVSKTPFLLRIGIHSGTITAGVVGTVHPKYCLFGETVTLASQMESLGMAGKIQCSKWAYQKAMETGRFEFSPRGRIDVKQRGLTETYFLTRSLKKSIWEIIDHDRDINVNSIEGYEELETAIENAVTIKSALPRPDQRNSAACSIS
The following text describes a protein:
Function:
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.
Sequence:
MMAAGAAVALALWLLLPAVGVGEAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYRLCFDNSFSTISEKLVFFELIFDSFQDEEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEDNLERVNFWSAANVAVLLLVAVLQVCTLKRFFHDKCPVPT
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKEENILYYVDNNVKSLQRNYEICLEKNIQELIIYYGIKLLKKYGKKNSIYKWNLYEEILKACIELKLYEYVDIYFKKLNDRFGHLNGKKIEILKGMVYELKDKNDEALCIYKNYIYNDPSDLLIRAKIVKLKKKVEGNINNVIQILNDHLKEFPVDVEAWHELGEIYLKNCYYTYALYCFEEILIHAPKNLYYILSCAELHYTISQYELSSKYFCLSLKLQKNNLRALWGIVLVNLSRYGNKKGKNLNDNVDVILTKKCIDRLYNLYDKNTNFLYRNIILQYLKEIGESFV
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFRFDIIYEYRWMFLYGALTTLGLTVVATAGGSVLGLLLALARLIHLEKAGAPMRVLAWALRKVSLLYVTLFRGTPLFVQIVIWAYVWFPFFVHPSDGILVSGEAAIALRRGYGPLIAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRYSVYEEPLYTVALIYLLMTTFLGWIFLRLEKRYNPQHR
The following text describes a protein:
Function:
A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth.
Subcellular Localization:
Cell projection, cilium, flagellum. Note=The flagellum attachment zone (FAZ) is a complex structure comprising a FAZ filament structure, a specialised microtubule quartet (MtQ) and the plasma membrane attachment, a specialised area of flagellum.
Sequence:
MALLNVISENPLTLQPGQVIAFDHLANGEHWQWALGTVVSSDKHVVVVEQWAVNEGSCETLKHNISSEIQKEMKRMGVFQEQLSSARDKLAAIRSENEDRVSAARAVFEDAKARVASVDEVHMREVTSQACPSPVAVEVLKSVLALAQNDPTVTNCSTWDDIRMEYRRPNAIADFISADITGKTYPNAEEICSSLNEQRLSSLAASRDSEAISSLHHWVLSALAYQEAYCRLTTDTRVQEQNDAIANCIAGMKGCRLKVMKLKEELERGGTPTFGGQLTSFTKTSVQLKAPLSSVISIVGVDPSAQDCVLTDDEVGLILDKAEQTRLQINDHFSHLSNSYMEAMAELHCLSMYTSELEERRLNLQERFVFSLFTNAGKTNAPRRERIETDVGLRSVEAPRGDSANNIKDLQEIIKELSSHDERWMYRNEPTVTTKHRKSYPGREWSKVVERKPEELLSTFRTEQAAACHVPEDAIRNIEFTATSEKLQVSFDVQHPVKQTAAEINKRLQEFPSRGMDRMLCDVDQPKKGLDRAIVEVCRAFDLREHAFRGMTFDKFIEEVAMKGRVGDKDAYESEIGDLLMLLDKIHNENRSLQYTLEKSAEEFRRQTASTMREQESLRQRNGELHAEIGRLRDLVEKLRDLADNQASELELLKLQKTQANQIRAQRNLSTFRGDDTAEPVYCVTLDELREQTEHCDQVERELERQREQCQNLLNAQDDLLAELSGVSEEKEKLEAECERLEAELRQMEEKSRLSEQGLSEMTQRLEEKQAEIEGLLENLEQLDEQLEALRAAEKSAQAHIEARDREISDLQQRLEGEIDDHIKTTALLEELRKHYNNLEELFDKQEAELMAYREKRQNAHKVRSLEPTLRPIGTQTKPFQEMVSADEISSEPLLSVTLDEYNDHMHRSNQFQQENDLLRQQLQQANDERENLHDRLEQLMAENQSLSEQLHNMHEELEREERDRSGVTLQNERLAEEIQRKTAENEQLVLENNKSRSDIRNLNVQVQRLMEELELKAAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKVAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKAAENEKLAEELELKVAENKRLAEEVTQRLSEKELLAEDTSARLLEADSANSALQCKVKHLEEKLTLLSSEKETALATLEAEIVDLLTQLKGLNGTNSALESLCASKEKELVFLREHCELWTDPTTKKEKVITRHVKVFDGNEWMKLITDRPEALMSAFVIDAGNACHVPGDQIHEVSFLNNKEKH
The following text describes a protein:
Function:
Involved in anaerobic respiration with Fe(3+) as terminal electron acceptor. Acts as an electron-transport mediator in the dissimilatory reduction of Fe(3+).
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MSRKVTKYSAVLAVSLFAAALAGCGSENKEGTVGTGPGGVATVGDSACVQCHSAVTEALTGESLIAQYQKSSPHNTAGLGCESCHGGGAQHNGVGPIPFAQPDASRCADCHDGTTAVATNSDTAFAESRHNIQTIRSGATCRRCHTHEGAVLSNIAGYTGDLATLEDTVNQNKVPLVSSYSQISCATCHEHGGGLRTIKATNGAAGPVVNWDPNNNRTVDQFDLCTSCHNMYSYNGSTLLTNGVPVNGVATGTVGHHETTWYRIIATTHFDNYSTGPQAGAGASGTNAKVEGYVLRRTGANPCFDCHGHEAKTNTRPGRDATIHTDWAKSAHAGGLLTAKYNAVGALTGAAAVNAAMNAYVDDTTAIAWTHYNWDASSRGSCQRCHTATGAANFMSNPAGYDPTGAGNSFSHLQGWSAANGSKQNELLYCWGCHTNAGTGELRNPGAITENYAGVNSTSTGTTGTAVTISYPDIAGSNVCMTCHLGREAGENIKAITDADGILGFVNSHYLAAGGQLFGKTGYEYATRSYAKPTFFAHDKIGTAAAPGTGTNGPCAGCHMTTPNSHSFLPVTKDGTGAVTAITSTACATCHAGAYALTPEALTAEEEEYVASLEALKAALAGKGILFFNAHPYFYRDTNANGIGDPGELVSSNAFTNWAGVYGLALWKDVMGAAFNANLLIHDPGGYAHNRFYVKRLIWDSIDFIYDGVLNNDVTAAIDAQVTATRLDSATATAAKAYLGTTRP
The following text describes a protein:
Function:
Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDAEASGPLLHVVLFEPEKAGNVGNVARTCSVLGAELHLIRPFGFHLHDREFRRAVMDYLQGVTLHEYAGWSDFQAQLPDAARVFAFSTHATEYHTRAGFKRGDYLLFGPESRGLPVWLRDALPKLKLPQPGRGRSLNLSVAVGAAAFEAGRQIERW
The following text describes a protein:
Function:
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Sequence:
MICRTIVEGTTKISVPIPPPDVNFPPSAAPVFYNPEMELNRDINVAATAAFVKRLLSRKDLKREEVRYVDAFSASGIRGLRIAGEVGIHSTMNDWNPEAFELIKENIKINGLEEKAQATRKNANVLLHEQKFHIVDVDPFGTPAPYLDAAATAAQGMLSVTATDTAPLCGAHLNSGIRKYAAVPLNTEYHSEMGLRVLLGACARECAKHEKGMLPLLSHVTRHYVRSYLEVLPGTKHADRALKSMGFSIYCPKCGFRGPVYGLAVHIEKECPACGALTKIAGPLWLGPFREPKFCNEVLSELEAHPLNTKEKAKKIITFCRDELDIPMFYDQHVICKELGASATGIETLIEALKAGGFEASRTHFSGTSFRTDAPIAEIKKIIQALSG
The following text describes a protein:
Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Sequence:
MINREDLLKNPVEDITLSDLKKYNDIVSVFDKIYGFSSEGIVNGSKILKEMIKNADLRFLSFTANLVSTGLRGLFADLIKKGYFNIVVTTGGTIDHDLARSFGGVYYKGSFDIDDTMLKDLEIHRLGNVLVPFESYGKVIEDVVRKFLPEITKDRKEISAYELLWEFGKRITDSNSILRAAYDKNVPIIVPGILDGSFGTNLFIQSQFLNFRINLFEDMRLIKDLIFSSKKSGALIIGGGISKHHTIWWNQFKDGLNYAIYITTAQEYDGSLSGAKPREAISWNKIRPDAKHVTIYGDATIIVPILAASLLS
The following text describes a protein:
Function:
Promotes cholesterol efflux from sperm which renders sperm capable of fertilization. Has also been shown to decrease levels of intracellular esterified neutral lipids including cholesteryl esters, fatty acid esters and triacylglycerols.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm.
Sequence:
MEVLKKLKLLLWKNFILKRRKTLITLLEMLMPLLFCAIVLYLRLNSMPRKKSSTNYPAVDVSLLPVYFYNYPLKSKFQLAYIPSKSETLKAVTEVVEQTFAVDFEVLGFPSVPLFEDYIIKDPKSFYILVGIIFHHDFNSSNEPLPLVVKYDLRFSYVQRNFVSPPRHLFFQEEIEGWCTAFLYPPNLSQAPREFSYADGGNPGYNKEGFLAIQHAVDKAIMRHHAPKAALNMFKDLHVLVQRFPFGPHIQDPFLVILQNEFPLLLMLSFICVELIITNSVLSEKERKQKEYMSMMGVESWLHWVAWFITFFISVSITVSVMTVLFCTKINRVAVFRNSNPTLIFIFLMCFAIATIFFAFMMSTFFQRAHVGTVIGGTVFFFTYLPYMYITFSYHQRTYTQKILSCLFSNVAMATGVRFISLFEAEGTGIQWRNIGSVWGDFSFAQVLGMLLLDSFLYCLIAFLVESLFPRKFGIPKSWYIFAKKPVPEIPPLLNIGDPEKPSKGNFMQDEPTNQMNTIEIQHLYKVFYSGRSKRTAIRDLSMNLYKGQVTVLLGHNGAGKTTVCSVLTGLITPSKGHAYIHGCEISKDMVQIRKSLGWCPQHDILFDNFTVTDHLYFYGQLKGLSPQDCHEQTQEMLHLLGLKDKWNSRSKFLSGGMKRKLSIGIALIAGSKVLILDEPTSGLDSPSRRAIWDLLQQQKGDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGSPSFLKQKYGAGYYMTIIKTPLCDTSKLSEVIYHHIPNAVLESNIGEEMIVTLPKKTIHRFEALFNDLELRQTELGISTFATSVTTMEEVFIRVCKLADPSTNVLTEKRHSLHPLPRHHRVPVDRIKCLHSGTFPVSTEQPMRLNTGFCLLCQQFYAMLLKKITYSRRNWMLVLSVQVLLPLAIIMLSLTFFNFKLRKLDNVPLELTLQTYGQTIVPFFIAENSHLDPQLSDDFVKMLVAAGQVPLRIQGSVEDFLLKKAKEAPEGFDKLYVVAASFEDVNNHTTVKALFNNQAYHSPSLALTLVDNLLFKLLSGANASITTTNYPQPQTAIEVSESILYQGPKGHYLVVNFLFGIAFLSSSFSILTVGEKSVKSKSLQFVSGVSTAVFWLSALLWDLISFLVPTLLLVLVFLWYKEEAFAHHESIPAVVLIMMLYGWAVIPLVYTVSFSFNTPGSACVKLVVMLTFLSISPVVLVTVTSEKDLGYTELSDSLDHIFLILPGHCLGMALSNLYYNFELKKFCSAKNLSDIDCNDVLEGYVVQENIYAWESLGIGKYLTALAVLGPVYITMLFLTEANAFYVLKSRLSGFFPSFWKEKSGMIFDVAEPEDEDVLEEAETIKRYLETLVKKNPLVVKEVSKVYKDKVPLLAVNKVSFVVKEEECFGLLGLNGAGKTSIFNMLTSEQPITSGDAFVKGFNIKSDIAKVRQWIGYCPEFDALLNFMTGREMLVMYARIRGIPECHIKACVDLILENLLMCVCADKLVKTYSGGNKRMLSTGIALVGEPAVILLDEPSTGMDPVARRLLWDTVERVRESGKTIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGISYSLQAKVRRKWQQQMLEEFKAFVDLTFPGSNLEDEHQNMLQYYLPGPNLSWAKVFSIMEQAKKDYMLEDYSISQLSLEDIFLNFTRPESSTKEQIQQEQAVLASPSPPSNSRPISSPPSRLSSPTPKPLPSPPPSEPILL
The following text describes a protein:
Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A. In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the with the SH2 domain of SH2D1A and SH2D1B. A 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Sequence:
MLWLFQSLLFVFCFGPGNVVSQSSLTPLMVNGILGESVTLPLEFPAGEKVNFITWLFNETSLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLKMEDTGSYRAQISTKTSAKLSSYTLRILRQLRNIQVTNHSQLFQNMTCELHLTCSVEDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVKIQYTDTKMILFMVSGICIVFGFIILLLLVLRKRRDSLSLSTQRTQGPAESARNLEYVSVSPTNNTVYASVTHSNRETEIWTPRENDTITIYSTINHSKESKPTFSRATALDNVV
The following text describes a protein:
Function:
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Has been found in complex 'B' and 'C' as well (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASNLPQERNHEACLLIRDLDPMVTESLLMELFIQAAPVVKVFIPKDKLTQQHSGRAYVEFQSSSDAEYALKVMKFVRLFNKEIKIKKENKDKVDIGANLFIGNLDADVDERILHDTFSRFGTIIFTPKVMRDENGVSKGFAFINFDSFEASDAAIEAMNSQFLCNKPISVTYARKKDSNERHGSSAERIIAASRNTGYLNQQQQQQSSSTSSTSTISTSTPQQQQQQQSQPLPPPIVTAGGIIHQQQIQQQQQLQQQQQQQLQLQQLQLQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHPHHQHPIPHPHPLPHQLRPHPHPHHPPPPPFNPMLMQFNPMMMPFGGMPPPPPHK
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MLCPLFQNVQTEGEITIGIDEAGRGPVLGPMVYSAFFTTNTEVISTMGFHDSKILSRTMREKLFTDIKESGVCGFSTRILTPSYISQMMCGPQKVSLNEIAFSAVRDIIHQIIRTSQRKIVHIYCDTVGPSKKYQAMIANEFKEVKLSQITVCPKADGLYPVVSAASICAKVTRDTCLDNWIYEETNIQTRQVGCGYPSDVDTIKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDVNLNRGVFGWGRKVMKKEKIKGYIGEWKEMELVLTNDLMIITYQKQIEYISLYVDYNITEYNIDDDVYQIEDKEQGIYYIKDIELKGLKEDINSYLRITDDVYQFPATPNDIFN