lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
Sequence:
MGFLEDKKRTLMNLELAIREGLVDEEIIPILNKINEIDNYYTTSSCIGRVGIMEIPKDKNPKLYSRWLGKWHHYASYDELFNALKNKKEGYIVFVMNSPILHIACKDIESAKKMLELAIHSGLKASSIKSISDKRVIVEILTTYKVDTPIGEDGEIFVDNNYLKFLLDYSNSKLKRAREILMRWANRLDELKK
The following text describes a protein:
Function:
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.
Subcellular Localization:
Nucleus.
Sequence:
MNSLKISDNEYALIEHPGFANNKDAFFQTLGGVQSIQKACQTSFQNPKQALLELNLRPKDKYHHPVQARVQSRNDLLVTIKKMDNSVQNVSRIRQVFLFRDMADFQYSTQNSPFVQKLDSTLRVLDYNAINKFSIDLTPVQRKHVDMPPPPVFSQTSLPMSYNFLQNPLVGRVRLPNGKTTIVNLKGQCRVWIITTNMGVESVPTCRHSKLGEPSKTIQEVIEALKPLFEKRPVWTRRALLNHLDPSYTHYLKFALPYLSYLWTSGPFRDTYTRFGYDPRKDSNAAAYQALFFKLKLNGKHKGTKTHVFDGKTLFPTNRVYQVCDIVDPTIAPLLKDTQLRSECHRDTGWYRSGRYYKVRDLMREKLFALIEGEMPSEVAVNMILNAEEVEESDRYSNFDEQDNTDLNDTVRGLNTSATDDRINDLMRNLMKRSQEHEGFEDLEEIDDDYDDIFGD
The following text describes a protein:
Function:
Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation.
Subcellular Localization:
Secreted.
Sequence:
MVNIIQDFIPVGANNRPGYAMTPLYITVHNTANTAVGADAAAHARYLKNPDTTTSWHFTVDDTEIYQHLPLNENGWHAGDGNGSGNRASIGIEICENADGDFAKATANAQWLIKTLMAEHNISLANVVPHKYWSGKECPRKLLDTWDSFKAGIGGGGSQTYVVKQGDTLTSIARAFGVTVAQLQEWNNIEDPNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVFQVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIAAQLS
The following text describes a protein:
Function:
Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.
Sequence:
MEIKEVAAAEAMTMGMPTVPSRFRRICVFCGSSQGRKKSYQDAAVELGEELVSRNIDLVYGGGSVGLMGLVSRAVYNGGRHVIGVIPKTLMPREITGETVGEVKAVADMHQRKAEMARQSDAFIALPGGYGTLEELLEVIAWAQLGIHDKPVGLLNVDGYYNSLLSFIDKAVEEEFISPTARHIIVLAPTPNELLDKLEEYSPRHEEVVPKTKWETEQLSCCKSCEIPPGLKEGTPIVQAQRGTMHALN
The following text describes a protein:
Function:
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The DSL domain is required for binding to the Notch receptor.
Sequence:
MVSLQVSPLSQTLILAFLLPQALPAGVFELQIHSFGPGPGLGTPRSPCNARGPCRLFFRVCLKPGVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLPDGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPSVCRPGCSPEHGYCEEPDECRCLEGWTGPLCTVPVSTSSCLNSRVPGPASTGCLLPGPGPCDGNPCANGGSCSETSGSFECACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGLVCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADPQRFLLPPALGLLVAAGLAGAALLVIHVRRRGPGQDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPEDGDSRSIYVIPAPSIYAREDWLIQVLF
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MAQRTEKEETEFKVLETLTTPATATTTLCSNNCGVTANPATNNMCQKCFNASIAAAGVDSGSTSKRASRSVNLRPSPAKVVIRPREIDPVKRDQQTVNRCSGCRKKVGLTGFRCRCGDLFCSEHRYSDRHDCSYDYKTAGREAIARENPVVKAAKMVKV
The following text describes a protein:
Function:
Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
FNSLMISFLLLLFSSVIAERHYDRLYNELSQSIANAKIKGEENIEISKELYYESEWKRDLAPFQSGITREMMGQLESLGNKYQIINHTVYRAKRCTFPARCQGVDKFLTRLAHRLEDTEFVLNDFDNPKLTKRARPLPLFSFSKKEDDYWDILYPAWSFHSGGPAISIYPSGIGNWSETKEELSKYSSSHPWSTRESRGFFIGSRTNHQRDSLVLLSRRFPSLVDASFTKNQAYRSPQDTLNAEPSTERPFEYNCNYKYLFNFRGIAASFRFKYLLACGSTVFHLDDGWIEFFYRKLIPYYHYIPLKERENNQKGLKTLLEYAIEHDEEMKKIGDNAHSWISSHLDESSIDLYWIGLLSSYSSLLKFPIERDVSLMKVSNEGSISSQFP
The following text describes a protein:
Function:
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Also acts as a regulator of long-range activity of Hedgehog (hh), possibly by regulating the switch between low and high level hh pathway signaling.
Subcellular Localization:
Secreted. Cell surface. Note=Associates with the cell surface via interaction with sulfated CAG chains on glypicans.
Sequence:
MAVEQIDKMAAKAGEATNKWIKPQQPLLTLLLLLATFSQLPAVCSSSILDAASLQEKDPLRDTSMNMIQRNYMVMHSASGSGDHSRSLKRANLANTSITCNDGSHAGFYLRKHPSSKKWIVLLEGGWHCFDVRSCRSRWMRLRHLMTSSQWPETRDVGGILSPHPEENPYWHNANHVLIPYCSSDSWSGTRTEPDTSDRENSWRFMGALILRQVIAELIPVGLGRVPGGELMLVGSSAGGMGVMLNLDRIRDFLVNEKKLQITVRGVSDSGWFLDREPYTPAAVASNEAVRQGWKLWQGLLPEECTKSYPTEPWRCYYGYRLYPTLKTPLFVFQWLFDEAQMRVDNVGAPVTPQQWNYIHEMGGALRSSLDNVSAVFAPSCIGHGVLFKRDWVNIKIDDISLPSALRCWEHSTRSRRHDKLKRSTEPSTAVSHPEHANNQRHQRHRQRLQRQKHNNVAQSGGQQRKHNHLSKEEREERKRLRQEQRQRRKQRRRQQQQKKANGGQEHRNKKDNSPKSSNGNDQRKQRRRQQLTAEERQEQRKRRRKAQQQQMKMQREQPAAGVFLEASAPQKTRSSNNASAGTKSKKRHRVPRVPEKCGLRLLERCSWPQCNHSCPTLTNPMTGEEMRFLELLTAFGLDIEAVAAALGVDMHTLNNMERTELVNMLTQQAN
The following text describes a protein:
Function:
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
Miscellaneous:
MISCELLANEOUS: The intein interrupts the potential ATP-binding site.
Sequence:
MVIIMEKPWVEKYRPKTLDDIVGQDEIVKRLKKYVEKKSMPHLLFSGPPGVGKCLTGDTKVIVNGEIREIGEVIEEISNGKFGVTLTNNLKVLGIDEDGKIREFDVQYVYKDKTNTLIKIKTKMGRELKVTTYHPLLINHKNGEIKWEKAENLKVGDKLATPRYILFNESDYNEELAEWLGYFIGDGHADKESNKITFTNGDEKLRKRFAELTEKLFKDAKIKERIHKDRTPDIYVNSKEAVEFIDKLGLRGKKADKVRIPKEIMRSDALRAFLRAYFDCDGGIEKHSIVLSTASKEMAEDLVYALLRFGIIAKLREKVNKNNNKVYYHIVISNSSNLRTFLDNIGFSQERKLKKLLEIIKDENPNLDVITIDKEKIRYIRDRLKVKLTRDIEKDNWSYNKCRKITQELLKEIYYRLEELKEIEKALEENILIDWDEVAERRKEIAEKTGIRSDRILEYIRGKRKPSLKNYIKIANTLGKNIEKIIDAMRIFAKKYSSYAEIGKMLNMWNSSIKIYLESNTQEIEKLEEIRKTELKLVKEILNDEKLIDSIGYVLFLASNEIYWDEIVEIEQLNGEFTIYDLHVPRYHNFIGGNLPTILHNTTAALCLARDLFGENWRDNFLELNASVSKDTPILVKIDGKVKRTTFEELDKIYFETNDENEMYKKVDNLEVLTVDENFRVRWRKVSTIIRHKVDKILRIKFEGGYIELTGNHSIMMLDENGLVAKKASDIKVGDCFLSFVANIEGEKDRLDLKEFEPKDITSRVKIINDFDIDEDTAWMLGLYVAEGAVGFKGKTSGQVIYTLGSHEHDLINKLNDIVDKKGFSKYENFTGSGFDRKRLSAKQIRILNTQLARFVEENFYDGNGRRARNKRIPDIIFELKENLRVEFLKGLADGDSSGNWREVVRISSKSDNLLIDTVWLARISGIESSIFENEARLIWKGGMKWKKSNLLPAEPIIKMIKKLENKINGNWRYILRHQLYEGKKRVSKDKIKQILEMVNVEKLSDKEKEVYDLLKKLSKTELYALVVKEIEIIDYNDFVYDVSVPNNEMFFAGNVPILLHNSDERGIDVIRTKVKDFARTKPIGDVPFKIIFLDESDALTADAQNALRRTMEKYSDVCRFILSCLTGDAKITLPDEREIKIEDFIKMFEERKLKHVLNRNGEDLVLAGVKFNSKIVNHKVYRLVLESGREIEATGDHKFLTRDGWKEVYELKEDDEVLVYPALEGVGFEVDERRIIGLNEFYEFLTNYEIKLGYKPLGKAKSYKELITRDKEKILSRVLELSDKYSKSEIRRKIEEEFGIKISLTTIKNLINGKIDGFALKYVRKIKELGWDEITYDDEKAGIFARLLGFIIGDGHLSKSKEGRILITATINELEGIKKDLEKLGIKASNIIEKDIEHKLDGREIKGKTSFIYINNKAFYLLLNFWGVEIGNKTINGYNIPKWIKYGNKFVKREFLRGLFGADGTKPYIKKYNINGIKLGIRVENISKDKTLEFFEEVKKMLEEFEVESYIKVSKIDNKNLTELIVKANNKNYLKYLSRISYAYEKDNFARLVGEYLRIKEAYKDIILKEIAENALKEADGEKSLRELARKYNVPVDFIINQLKGKDIGLPRNFMTFEEFLKEKVVDGKYVSERIIKKECIGYRDVYDITCHKDPSFIANGFVSHNCNYPSKIIPPIQSRCAVFRFSPLKKEDIAKKLKEIAEKEGLNLTESGLEAIIYVSEGDMRKAINVLQTAAALSDVIDDEIVYKVSSRARPEEVKKMMELALDGKFMEARDLLYKLMVEWGMSGEDILNQMFREINSLDIDERKKVELADAIGETDFRIVEGANERIQLSALLAKMALMGR
The following text describes a protein:
Function:
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MFAKAFRVKSNTVIKGSDRRKLKADLSSAFPALSAVQLSELVPSKEELNMVKIYAHRGDAMTLYVLHKNPIFFELEKQLYPTVYTLWHYPDLLPAFTTWPAVLQKLAGGADLMLPGVVVPPCGLPEVQQGERCAINLVRNRAPVAVGTATMPSAEMQRAGMKGKGVAVLHAYMDQLWGFGDRSGPPSIPPLVPEPPGSEEEEAGSQGEEEEEEGVPCASRDEDPGADTPCQALRDLQLSGGQDGEAEGDTSECPEDGQEEADSRSPQEQMDALLLQCFLHALKSKVKKSELPLLASSFLRNHMFSCCPGGKQLDLKKSSYKKLSRFLQCMQQEHGLIQVKELSKGVDSIVDVDWSHSELRSFAVPTDREAEDCPQESCGDASPARSYRPPEISTLYGVSARMEPLFKDTQHRKGAALSAGDVRAIITDYVKRNELVDENNKNYVTVNPTLCDCLLDKSEYQLVDKLKWDSLFARCLERMQPCHQLLFPGQQPIVKKGHMEPIDITVASRGSNKKVTLIKNLEAYGLDPHDVATQLQHWVQASSGINPLPGSKDKVQVQIQGNQIARVGKLLLEDYKIPRKFIQGLDKVPKPSKKK
The following text describes a protein:
Function:
Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain.
Subcellular Localization:
Mitochondrion membrane. Peroxisome.
Sequence:
MFISAGQHKYNLSNYLNQQTTLAVFLGVKEVEIDQIQQLTEQIYKLSFKNSKKQIRFHTKSDISQVQGNQLEKDFTIAQKLCAANMPVPKALFYCKDQSVLGFPFYATEYVEGRIFNMEQLLNISQAKKRLLFQEVSKALAHLHSISFHYLGLGEVDQNTHHYETLNNKLHNLYKQHETKISTNMEDLLYWLSLNTPVKSDLDNLCLIHGDFSLSKVVFHPTKPAVLAILDWQQAQIGNAFVDLASFVLPYYIPYSNGQHQVDGWFGVEEIMGQPSIQDVLSAYFTTRSSQTITDIRYQLILSIVKSSIDQQIHYKQYKEEKYYENSLFLTKAGYEIISEMTEGDPFGIKMRATNDGQIWSHWPVSERCKSYYYRIKDFMRDEVFPIEKAILDKAREVPRSLPNKPITELEELQRKAKSVGLWNLFILDPMYGKGLTNLEYVFISEIIGLSFIGHVVFNCLAPETGNIRLLIAYGTQYQKEKYLNPLLEGKCKSFFAITEKDVSSADQDNNKFTITPTDGGFILNGGKWFVQNAADERAIFGIVVGKSSSHTNNPNETQSMILVEMNNPKIQITRQFSSQNFYDLPHSYSEIQFNNAFIPKENLLGQLGGAIKMIEDRLLEERLNHCARLNGLTRRSLDLTLSRSEKRVIFKEKLKDNAAFQEKLGDLEIAYQSCRLLCLNAGLLLDSVGNTHFNAFLAVSECKAHIPKASQYILDSCMQIFGAEGVTEEQPLSLILRLAKALRFVDGPCEFHLRQVSKFVYGNHIFNDLNNAQGYGLAKL
The following text describes a protein:
Function:
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MDLSKIASTINMRYYSQLGGFQVGGAVSGLDTQSIINAILEAESQPLQNLTEKYEKYELMQEAYTEVKTKLREFRDLVYSFKLQSTVVQKTAVSSSSLLSAEASSVAVTGVYHVKIVQTATYTTLAGASEVVPPPDSTKTFGELDYMYTPQEGTVRLYNNETGNYVEVQVLSTDTIDDIVSKLNSALSSAGITGSVSYDTSTGKISITSDKNFSLVDITGNFTKVFHLDEASLNYSGGNYSFTSTASVSGLSTAKTLQQIATYTSKTIISGKVKINGVEIDVDQNDTLSSLIEKINDSEAGVTASYDYHANRVVIISKTSGPEAITLEDTYGTGLFSLLGIENHSLYVGQKAHLQISMDGTNWADVYSDTNDVEYNGVTFHISGMTSETITVDVRVDTDAIVEKIKEFVDKWNETMDYLNEKLTEESITDKDEEEMTEEEKMKGVLKGDDLLEEIFSRLRGFITYKAEGDINYLWELGISTGDIGTGYENMMKGHLEVDEEKLKQIVEEDPNKVWEFFGGENGFATQLDDYLWELVKFNGRIDQVAGISGRIEREQRFLATQIASWIERLSKREQELWRKFSVMEEVISQLQSQGSWISQALQGSSNK
The following text describes a protein:
Function:
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MKHSYFISDLHLSETQPELTALFVDFMQNLAPQAERLYILGDLFDFWIGDDEQSALIQQVKDLIKFVSDQGVQCYFQHGNRDFLIGERFSKETGAQLLPDYQLITLYDKKILLCHGDTLCIDDEAYQQFRRRVHQKWLQRLFLCLPLKVRVIIAEKIRAKSNQDKQAKSQEIMDVNQAFTAEKVQEFGVNLLIHGHTHREAIHQQEEFTRIVLGDWRKNYASILKMDESGEFGFIKD
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MDFAEQDVDVFGEEYDGAEAEAEGGGGASSGSSSPSSSSSSSAAASSSSSSAASSGRSSSPAAGGGDEDGADDGDGGEYDSFDVVPVRPAAGYGDDEEEARDLFGSDNEEYVKTPARSNYLVPVLPPIRNTNNFSRGGRGGRGPPILPRPGGHPGGRNNYGHGGRFSYGNGRNVEGFVSEMKLNKSEETLSRKAVAFQEPCEIACYSRVEGGDVYFDDRSLRLFKRNICDYAGEDLNKGFETFIEKRDLGSQGFGDLLACIRNSNLPLQNIHFVTYRNNLNKILATAYLKDPWKMGVHKRNGVVYLDVHKLPERPQSEIERRRCFWGYSFENLATENSIDEDGSGIDANVEYCSVIKTKLGAHRIVMGAEMDCCDSTDDGRRFYVELKTSRELEYHTVEKFEREKLLRFWIQSFLAGVSYVVVGFRNDAGVLIRTERLRTKDITQKVKAKSYWQGGVCLAFADEVLCWLYGTVKENEDYVLQFAHPFHRLELLKAQSPCPDAITLHVEQLTGATN
The following text describes a protein:
Function:
Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways.
Sequence:
MGNTWAVYSETQSAIFLPPWIALAVRPRPGVWEYIRVNIHALVVEELQVTEFLHFKEELVEGNLNGNFVLELDFEPFTAQFPHPTLSKSIGNGVEFLNRHLSAKLFHDKERLHPLLEFLQVHCYTEKNIMVNTRIQNVFSLEHVLRKAEEYLSALKPETPYSQFEHKFQEIGLERGWGDTAERVLEMIENFLGRIPMVFNVVIMLPLGYFAQDDVLGYPDTSGQVVYILDQALESEMLHRIKQQGLDITPRILIVVGTTCNQRLAKVFGTEYSHILRVPFRTEKGTDFANEIAGELQGKPDLIVGNNSDGNIVASLLAHKLGVTKKYHFSCQFTADLIAMNHTDFIITSTFQEIAGSKDMVAQHESHHFYTSLTVPRCVLKDRNKPILFTMARLDRVKNLTGLFRWISSQMNRVRNGELYRYICDMRGAFVQPALYEAFGLTVVEAMTCGLPTFATCKGSPAEITVHGKSVFHIDPYHGDQAAEILADFFKKCKRLLNLVAVYGFWKHVSNLDHLKSHRYLEMFYVLKYQKLAESVPLAVE
The following text describes a protein:
Function:
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores; Plays a fundamental role in microtubule-organizing center structure and function.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nuclear pore complex. Nucleus, nucleolus.
Sequence:
MSLALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEILKNILLLPIWSRCLSLNREFFSEVNQEEFIAIMTGDI
The following text describes a protein:
Function:
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MAELLLGVNIDHIATLRNARGTAYPDPVQAAFIAEQAGADGITVHLREDRRHITDRDVRILRQTLDTRMNLEMAVTEEMLAIAVETKPHFCCLVPEKRQEVTTEGGLDVAGQRDKMRDACKRLADAGIQVSLFIDADEEQIKAAAEVGAPFIEIHTGCYADAKTDAEQAQELARIAKAATFAASLGLKVNAGHGLTYHNVKAIAAIPEMHELNIGHAIIGRAVMTGLKDAVAEMKRLMLEARG
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MMNELMHQCPITFGYSCGIIAMIIISLLGILPPISLVYYKKAVFHDFELWRLVTGLFYFGKPDFMMLISLAFRIKFMHTLETTVYNQRKSTFLFIILLMIIPVYILSDVFGSFSSALSLSEAIEMLAGKLMQANMLIFGIIPIPIRFVPIFQIFMSVVQNQSPIPIIIGILSGHLVFYLLYIFPVITKTPIFRTPNFLRQLLD
The following text describes a protein:
Function:
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability.
Subcellular Localization:
Mitochondrion inner membrane. Cytoplasmic vesicle. Note=Cytoplasmic vesicular structures.
Sequence:
MALLVRVLRNQTSISQWVPVCSQLVSVSPTQRQWSSTSQWLQKNQSRVCLGSEQTVGADTAQNRKYHNTSKLLTTQDFPQPVEEKVGPFTKIIEAMGFTGPLKYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRTGKYMCRIIVHFMWEDVEQRGRVMGVNSYILKKNMALMTNNFYAAILGYDEGILSDDHGLAAALWRTFFNQKCEDPRQLELLVEYVRKQMQYLDSMNGEDLLLTGEVRWRPLVEKNPQSILKPHAPTYNDEGL
The following text describes a protein:
Function:
Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53.
Sequence:
MANYQTAHAQERRIQELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNRDELPKPVRVTKQARTTSAKQPTTSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHMESAITQVSIASAPPAAAPPAPAATAPAVPRKSGDKSVPKCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQAQSQGKFHTEAKAHVQTAIQTQKDNIKDSPPRMIQESQSLTEAKAPIPKNRYSNKMCQEKKYKKKHHSMSCITRDTFPSETEHRQQREERAYQRQMKRELQLKESYRRRIEAESEPLKETTEQESKTIKVIEQKVCEHTEKKADESLSKDQQKDSITFGTCVRERIHHLELEMEKCTEELVDFVELNADVLNYANVSTHLKKLQRSKESDEKDEDDRRALPEGIGGPGSQNYEIFRQEQEKERQRQVQEFLARDETNEYDNLDLDHAYRAKYYTAYKEIGKELNPAPDSGGRDSGSEHSPGRDNYTTYADYFLKYTTPQQNWNDLERANGLQREHDRIYGLFWLNDRRQEEKYRRKLAQNDQEELPVHHHKACRHRHHKPNHHAPYDHMRPTEDDIQEADSLPESN
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMNCPIRKKRPTCDSDFSAIVVPSMHGSGYLDYTVENHALRSLMVMDEFRKHGMLCDVLLHVTYKERVVDFKVHRVVLASCSPYFRAMFTRGFKECSASEVTLCDVCPEVVGRLIDFAYTARITVGEKCVLHVLLSAMRFQMEDVAKACCDFLIKHLEPANVIGISRFAEEIGCTELQQHCREYVNTHFSEVTKADEFFSLSHCQLLELISQDSLKVLCESEVYKACTDWVRADMESRAQYLHALLNAVHIYALPPKFLKKQLVSCPILSKANSCKDFLAKIFQDITLRKLTPAPIRGTQLIYVAGGYQHTQNSLASMVAFDPRRNNWLKLADMETPCSGLGACALFGLMYTVGGKNLSLQNNTESNSLCCYNPMTNQWSQRAPMNMPRNRVGVAVVDGCIYAVGGSQGSVQYNTVERWDPDSNRWSFISPMSVARLGAGVAACGGALYVAGGYDGHNRWNTVEKYQLDTNTWHPLAPMNTIRSGLGLACLNSSLYAIGGYDGQSQLCTVECYSMARNIWEPRASMHHCRSAHGVTVHQGRIYVLGGYNQHGFLSSVECYCPETNTWMYITDMPEGRSGMGVTVTMEPCPGRLLELEEEEDAEVM
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MIFIEKLRTDILELIQSSEFEKKKLIKVSEEDSNYILEILNSIWEATQEGSLCVPVKQEWKKILKIKLPGLVVDRFENTEWVYFEKTYHSKIELERLLKERIENNVSVNVDTDRVEKILKDLESKSFSLKKNQKKTIFSCLNSSFQIISGGPGTGKTTVVAFLLQILNELKQLPSPEKIALVAPTGRAAQRLTESVQENLKKISTSLENGFLRGQTIHGLLNYKQSLGGFYYNRERYLPHRLIIVDEVSMVDLDLMLSLWNSIPKNETIQEGTIPFRFILIGDPHQLPSVEKGAVLSDFLSVLESKRFHFVSKLEESNRQQPNTNGEVSKIVTLAEEILKYSPENLNLGTKIDESFPKTNQIKENILYKSEVVWLQNIESSTSDYFSRDELVEKLWKEIFYPQIDRISSWKIQDSFCFDKPDFIQKFQEELKRFRCLTIFRSGYWGVDAIQTKIMNLAAQNLFFGKGGNFFAKRLSKGIYFVGLPILITRNDKSRKLFNGDIGIVLKTESTGELRAVFPIEGKLFQFALDTLPEHEPAFVMSVHKSQGSEYDTILIYLPDSIEEEKSNGLLNRQVLYTAITRAKKQVILAGNPQTWEIGIANFQNRNTGFRI
The following text describes a protein:
Function:
Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and for repression of CHA1 expression.
Miscellaneous:
MISCELLANEOUS: Present with 3380 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Sequence:
MSDTEKDKDVPMVDSHEATEEPPTTSTNTPSFPHLAQEQAKEESATLGAEVAHKKINYEQEAQKLEEKALRFLAKQTHPVIIPSFASWFDISKIHEIEKRSNPDFFNDSSRFKTPKAYKDTRNFIINTYRLSPYEYLTITAVRRNVAMDVASIVKIHAFLEKWGLINYQIDPRTKPSLIGPSFTGHFQVVLDTPQGLKPFLPENVIKQEVEGGDGAEPQVKKEFPVNLTIKKNVYDSAQDFNALQDESRNSRQIHKVYICHTCGNESINVRYHNLRARDTNLCSRCFQEGHFGANFQSSDFIRLENNGNSVKKNWSDQEMLLLLEGIEMYEDQWEKIADHVGGHKRVEDCIEKFLSLPIEDNYIREVVGSTLNGKGGDSRDGSVSGSKLMECVNDAVQTLLQGDDKLGKVSDKSREISEKYIEESQAIIQELVKLTMEKLESKFTKLCDLETQLEMEKLKYVKESEKMLNDRLSLSKQILDLNKSLEELNVSKKLVLISEQVDSGIQLVEKDQEGDDEDGNTATGHGVKRVGKEGEEVGEGDSIAKLQPQVYKPWSL
The following text describes a protein:
Function:
This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction.
Miscellaneous:
MISCELLANEOUS: The expression of this stringently regulated protein during cell development is mediated through cell-surface cAMP receptors.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the membrane by a GPI-anchor that contains a phosphoceramide moiety. Such anchor mediates a fast and long persistence cell adhesion of the protein.
Domain:
The C-terminal region contains clusters of proline regularly alternating with a hydroxyamino acid. This domain might act as a spacer to elevate sites active in cell contact into the extracellular space.
Sequence:
MKFLLVLIILYNILNSAHSAPTITAVSNGKFGVPTYITITGTGFTGTPVVTIGGQTCDPVIVANTASLQCQFSAQLAPGNSNFDVIVKVGGVPSTGGNGLFKYTPPTLSTIFPNNGRIGMILVDGPSNISGYKLNVNDSINSAMLSVTADSVSPTIYFLVPNTIAGGLLNLELIQPFGFSTIVTSKSVFSPTITSITPLAFDLTPTNVTVTGKYFGTTASVTMGSHIYTGLTVQDDGTNCHVIFTTRSVYESSNTITAKASTGVDMIYLDNQGNQQPITFTYNPPTITSTKQVNDSVEISTTNTGTDFTQISLTMGTSSPTNLVITGTNEKIVITLPHALPEGEIQFNLKAGISNVVTSTLLVTPVINSVTQAPHNGGSITISGIFLNNAHVSIVVDQNTTDIVCAPDSNGESIICPVEAGSGTINLVVTNYKNFASDPTIKTEATTSTTYTIPDTPTPTDTATPSPTPTETATPSPTPKPTSTPEETEAPSSATTLISPLSLIVIFISFVLLI