lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit. Also functions as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS.
Miscellaneous:
MISCELLANEOUS: RNF123-mediated maturation of NFKB1 restricts tumor growth by promoting activation of the NF-kappa-B complex, leading to expression of tumor suppressor genes. Activation of NF-kappa-B promotes tumor suppression via CD274/PD-L1 and chemokines-mediated mechanisms.
Subcellular Localization:
Cytoplasm.
Sequence:
MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFSSSEHAPPAATSRKPLNFQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTIAILRHEKSRKFLLSNVLFDVLRSVVFFYIKSPLRVEEAGLQELIPTTWWPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNMPMLCPPEYMVCFLHRLISALRYYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQPLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADARIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQQGPDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGTALPAPDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA
The following text describes a protein:
Function:
Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.
Sequence:
MKLVYMILLQAALLLCPNGSALTDDSTESVGEEKPTEACPVKLKISGKCDGEECPYQIHLPPMTLQLPKQFRLIEKTLKEVQSLKEVVNKMKKSCQDCKLQADDNQERESNEFLPPATDGPTDQGKVQDNRVKELQSKVSKLSASLKNAKNQIHSLQGRLEQINLINMNNVENYVDDRIANLTFAVNTLGDKCSSNCPATQPNPVMHLLQGDCSNYFAAGKRHNGIYKIIPDPRNGSFDVYCDMESMGGGWTVIQMRQDGSVNFNRTWQEYKNGFGNLTREFWLGNDKIHLLTKSKDMQLRIELEDFNGIREYAKYDQFYVANEYLKYRLSIGSFSGTAGDALHFNKHYNHDQKFFTTPDKDNDRYPSGNCGAYYSSGWWFDACLAANLNGKYYHKKYRGVRNGIFWGTWPGASDDNINSYRVPFKKVKMMIRPKNFAP
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF-alpha processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR. Contributes to the maintenance of intestinal epithelial barrier and plays a role in the regulation of intestine inflammation by switching interferon gamma receptor 1/IFNGR1 from clathrin-dependent to lipid raft-dependent endocytosis route to limit STAT1 activation magnitude and duration. Acts as a modulator of the endothelin axis by associating with endothelin converting enzyme ECE1 and regulating its activity of conversion of the endothelin-1 precursor to endothelin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAGVNVCIKCSMFIFNFVFWLCGAIILSVAISIRAGKIGQEILAPGDADLNLFIAVNILIFVGAVIMILGFLGCCGAMKENQFMMILFFVGLLMILLLQVAAGIVATTRKSKTEQALNKTLLINARLLSSTDENERVFQKAFSELQEELKCCGLVNGASDWGSNFQHYYRTCECPSESDSSCTKYSGKTIYKQSCFASISQMFSKRLFIVLALAFGLAAIEVLGLIFSIVLYCQMRKK
The following text describes a protein:
Function:
Involved in the ethylmalonyl-CoA pathway, a new acetyl-CoA assimilation strategy that operates in a number of bacteria and replaces the glyoxylate cycle. Catalyzes the oxidation of (2S)-methylsuccinyl-CoA to yield mesaconyl-(C1)-CoA. Highly specific for (S)-methylsuccinyl-CoA.
Sequence:
MTGQPLLGDLLTLASDALPEVEALFETARSALKERVTTDGKVSSKALEEEQFAAHALSWLATYVESLRQMRAWAGRLETEGRFGEMEALILQIAFGEYLAQIRGGIPMSQTETARVQDIGIELGHPGEAVRRLIQAGNTPAARARLVALMRDNHGRATFGASGLDEELEMIRDQFRRFADERVAPHAHGWHMRDELIPMEIVEALAEMGVFGLTIPEEFGGFGLSKASMVVVSEELSRGYIGVGSLGTRSEIAAELILCGGTDAQKAAWLPKLASGEILPTAVFTEPNTGSDLGSLRTRAVKDGDEWVVHGNKTWITHAARTHVMTLLARTDLETTDYRGLSMFLAEKVPGTDADPFPTPGMTGGEIEVLGYRGMKEYEIGFDGFRVKAENLLGGVEGQGFKQLMQTFESARIQTAARAIGVAQNALEVGMQYAEERKQFGKALIEFPRVAGKLAMMAVEIMVARQLTYHSAWEKDHGQRCDLEAGMAKLLGARVAWAAADNALQIHGGNGFALEYQISRILCDARILNIFEGAAEIQAQVIARRLLD
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTGWLLVAAGFVGAIVIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWVVGHSENFSASITTMQAVIWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMKAFTAAVLGGIGSIPGAMIGGLILGIAEALSSAYLSTEYKDVVSFALLILVLLVMPTGILGRPEVEKV
The following text describes a protein:
Function:
Plays a role in evading host innate immune response by inhibiting host inflammasome activation. Interacts with and inhibits NLR-mediated interleukin-1 beta/IL1B production in infected cells. At the host mitochondria outer membrane, interacts with the BH3 domain of host BAK and prevents BAK from binding active BAX. In turn, host apoptosis is inhibited.
Subcellular Localization:
Host mitochondrion outer membrane. Host cytoplasm.
Sequence:
MLSMFMCNNIVDYVDDIDNGIVQDIEDEASNNVDHDYVYPLPENMVYRFDKSTNILDYLSTERDHVMMAVRYYMSKQRLDDLYRQLPTKTRSYIDIINIYCDKVSNDYNRDMNIMYDMASTKSFTVYDINNEVNTILMDNKGLGVRLATISFITELGRRCMNPVETIKMFTLLSHTICDDYFVDYITDISPPDNTIPNTSTREYLKLIGITAIMFATYKTLKYMIG
The following text describes a protein:
Function:
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
Sequence:
MTKDLYIILSDYLRQYANGVVSQLPKEPEGRDAPESPGEEIRCPRCGSKNVVEDPNTGDLVCQNCGLILDSSALDFSKDWRAFDSDEYIERAHAGAPITPLRPGFGLDTDIVLTKGASKKSVNLLKRAQKHAADSKEKTIEPALRKIRDAADSLVLPQETIEDAATLYRMAARAGLVKGRSMDAMVAAVIYAACRRTDVPKTLEEISKFFALEEKEIGRSFRFLFRKLGIQIPPPKPENFVYLIASKLSLPEEVATQAIRIIKIAKRNGATMGREPVGVAAAAVYMACQELGLHRTQRELAQAANVTEVTVRNRYKELIARARNDWLEEIGEEKLNELKRRVAEYMKVSQAAQPVK
The following text describes a protein:
Function:
Required for cytokinesis, contractile vacuole function and development.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=In starved cells it binds transiently and in a calcium-dependent manner to the plasma membrane and intracellular vacuoles. In some cells, the transient membrane localization is observed to occur multiple times in an oscillatory manner over several minutes. Also found to be associated to the plasma membrane, contractile vacuoles, organelles of the endolysosomal pathway and phagosomes.
Sequence:
MNLKPPTSKVELRIKCHKILDKDTLSKSDPRASVYEKDRAGQFRLIGKTETIQNQLNPEFKTPIVIDYRFEEIQVLKFEIHDVDKNDEDFIGDASCTLTSILSKPGQTVCLQLLTKSGKHAGSMTVIAEEIKNTLQTIKFNLIGKKFDKKDLFGAGCDPYLIISRKVPSTNTFVKIYESQVQKGTLNPVFSGIEMKLEELCGGDMQREIKFEFYDWDRIGKHDYIGEFHTNAQELLQPNQAFNVINSHKQEKKSGYKNSGTVSVSDAVIEREYNFLEYIMGGCQMNLIVGIDCTASNGDSNDPNSLHYKNAQGLNQYANAICSVGNVIVPYTTTPLIPVYGFGGIMPGQSEVSHCFPMTLNASNTLCCGVNGVLDCYYDNISKIQLHGPTYFAPLINMAARYASQGQSQSNQKYTILMIITDGEILDADNTIDAIVKSSGLPLSIIIVGVGNANFTNMNILDGDDAALQSGGVRAERDIVQFVAMRDYLNRPNELAAEVLREIPTQFLSFMKKYKFRPNPPPPPPPVIIGAPPQYDNPTTTTTATSPSTGIDLNKGSNVGLNLTKTESSPSPSGGAGIDLNKGSVVDITKGVSNVSLEKN
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Sequence:
MANEFKFTDVGEGLHEGKVTEILKKVGDTIKVDEALFVVETDKVTTELPSPYAGVITAITTNVGDVVHIGQVMAVIDDGAGAAAPAAPQPVSAPAPAPTPTFTPTPAPVTTEPVVEEAGASVVGEIKVSNSVFPIFGVQPSAPQPTPAPVVQPTSAPTPTPAPASAAAPSGEETIAITTMRKAIAEAMVKSHENIPATILTFYVNATKLKQYRESVNGLALSKYNMKISFFAFFVKAIVNALKKFPVFNGRYDKERNLIVLNKDVNVGIAVDTPDGLIVPNIKQAQTKSVVDIAKDIVDLANRARSKQIKLPDLSKGTISVTNFGSLGAAFGTPIIKHPEMCIVATGNMEERVVRAEGGVAVHTILPLTIAADHRWVDGADVGRFGKEIAKQIEELIDLEVA
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MASDDLFPDSVKDFVFDLHDVSRRSFIPSEQHSLYVGSFRDVTAKYFPTSAWPTPAQISSECGGDPLFLSLYAELTLRHLQSVKRPNVHNRIEGWHTYRQLFDLLLSEAPEEEGGADAEKKKKESLYLVPEWCFDILHEFLYQFQGFCQFRTTTYCAAAKFSSDNDGENKAIPSHVADAIDALNSNRDAWAVETVLYYLHRLVAVGSGSNASATYRYLAILSLVTISRLECLLGDYKAAISALDVSAEELVNGVFPARLSLAYHAGVSYLMLRRYKDAVGVLGGICLFMQRGFKTGQLRKIPGSEQFNKLFDRMIALLAILTHICPTAILDDSIASIVRDKHANNLSKIESGEEGYEDLFVFACPKFVNAAVPDYAQALKPGAEMMPYGQDAYKLQVHHFMNEMTAHQTLRKMRSYMSLYTSIGVEKLASFNDMKVEEFEPWLTCFKHKVRQLERGEGGDKMGTAMDIHYYVGENLVHVDEAEKVRRFETFFMKQIANNDDILRQVERLRMDV
The following text describes a protein:
Function:
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Sequence:
MEDKPSIHRERKETKHRLNLLDKMIHQSLKPATLTRCLDQDSPASRPPRNGRLNRTYLPLHLLMMPMIWFFVASGVRATGSDRSGSSSFNSTHERHPAYLLTGTNGVVASEEIRCSTIGIDVLKDNGTATDAAIATALCVGVVNSFSSGIGGGGFMIIKPPTGCKHKPCSVQAPMTINFRETMPNGEFFMEAALKSSSSRVGGLSIGIPGELAGFEAAYRRFGGGVTWKRIFQPSIDLARNFSVGSALSSKLSTPNADWMRTKREWQTIFQPVNHSQPSRQGQWIQRPHYARTLETIAEKGIHPFYHGDIAKQLVETINREGGKVSLKDFQAYEPVVEQAINTTYHGYNIWTTGPPSSGGILLHVLNILERYSLHRHTRSPLAEHRFVESLKYAAAARTELGDPSFLGSAQLTRIKQIKSKAYGLETSLKIDDNRTYEYSHYHPKYDTVEDHGTTHLSVIDRFGSAVSLTSTINLYFGAKVMDPHNGIILNNQNDDFSLPGQSNAFELFSSPLNHPATGKRPVSSMSPIIVDYLHPQPNQQPEFFCALGASGGSRIFGAVAGTLLKLLWGYDLSHAIEDPRVHHQLRPNEASIETTYRSDFIDGLRSRGHNISMVEITEAMSVVNGIHKRISDDLLFGSSDSRKGGVPAAY
The following text describes a protein:
Function:
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Can use other acyl donors, but with less efficiency. N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The last loop motif confers selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor.
Sequence:
MATAAAETLGLLWGWLWSESFWLPQNVSWADLEGPGDGYGYPRAQHVLSVFPLAVCIFSVRMLFERFIAKPCALRVGIKDSPVNKVEPNDTLEKVFVSVTKYPDEKRLKGLSKQLDWSVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTYYLCIFCYGIRFLWSMPWFWDTRQCWYNYPYQPLSRELYYYYITQLAFYWSLMFSQFIDVKRKDFLMMFIHHMIGIMLTTFSYVNNMVRVGALIFCLHDFADPLLEAAKMANYARRERLCTTLFVIFGAAFIVSRLAIFPLWILNTTLFESWEIIGPYPSWWLFNALLLILQVLHAIWSYLIVQTASKALSRGKVSKDDRSDVESSSEEEDETTHKNNLSGSSSSNGANCMNGYMGGSHLAEEQGTCKATGNLHFRASPHLHSCD
The following text describes a protein:
Function:
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MNGAQALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGVATGAADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDAVAGTVSGWVRRTEAAADVGADAEAAIAASRSGSQIATLILPADVCWSDGAHAAAGVPAQAAAAPVDVGPVAGVLRSGEPAMMLIGGDATRGPGLTAAARIVQATGARWLCETFPTCLERGAGIPAVERLAYFAEGAAAQLDGVKHLVLAGARSPVSFFAYPGMPSDLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVAGASRPQLPTGDLTSVSAADVVGALLPERAIVVDESNTCGVLLPQATAGAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDRPVLCLESDGSAMYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAGSDPGPKALDLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPGPHLIDVVVPSLVG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MDTMNFDLNLGFFDHPSSNDQPQNISIDELLSGSIREVDSNHPTVNHRLPAVHRHIPVPTVAVNPPPGVAASGAAADNDEKVQEAIKTGENGDEGSFFDCNICLDLASEPVVTCCGHLFCWPCIYRWLFLHSNAKQCPICKGEVTMKTITPIYSRSNVPHVTKAIDPNSSYKIPSRPPAHRIESWRHSFQRETLNLPIIEMVRRLDNNRFHLSRDPLSSNPQEIPSTHLLNRIFTSRGMRRGRDSVPATSPEVTVDLPNDYIPNLTSGESFVDSYFRDHPEEINQDEFPLIDRHSMSSVAGIIQSEVTTTSMSSRRRREPATSTVLDVDRGNSRPRRRRLL
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDHVHFERELTLLKSDVSKMLFLVSESLNDAIESLETMNETLARKVLESDDMIDELNREIEEKAYQIIARYNPILKQLRYIITILKFSNDLERIGDLSCNIAEKCLFLSEEKIKFEMLKELKDMFGSTLKVVQDAFKAFVEEDVDLAFRLWKFDDVIDEMEKKIRRIVVERIREGNISAELALVYILIARDLERVGDHANNLCEEVIYIETGKNMKEFLRGVESGSEGADS
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEQNNGTEVKEFILLGFAGQHRSWLVLFIVFLVIYVVTLVGNIGMILLIKIEVLQNLMSTEKSISFIGCMVQLLVYGTFVTSDCYILAAMAVDRYVAICNPLRYPTVMSQRVCIQLLIVSYLIGFLNTSVHVSFILPLNFCKSNKINHFFCDAPPILALSCSSIYFNVMLIAAFVGFNLTCTVSVVIFSYIFILAAILKISSAAGRKKAFSTCASHLTAVTLFYGTLSYMYLHHRTLESQEQEKLASVFYGIVIPMLNPLIYSLRNQDVREALKGVGKKYFYFELWFLTQHGLTGRPTFLSYFSTAEDVANVHEIQSFLSCISST
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA.
Sequence:
MLYVGKLNSNKKIKKKYKFCNSVGESTVSDSFFCGEFFLLLILLSAEWLKARCTGKWKEKVKIRYNKQRTKNQTKQKQKTKNKQTNKKPRRGILCSIYCKSLNFPWSFPALLGQELALPLLARRRQRCNCIWSSRIRVHPTPAASTIPPKFNPKEIKVMFLRCTGGEVGATSALTPKISCWAQIEVVPSTSSLIIKALKEPPRDRKKQKNIKHSGNITFDELVNIAQQTRHGSLAREHSRTIKEILGTAQSVGCNVGGCNYHDIIDEINSYAVECPES
The following text describes a protein:
Function:
Releases the terminal D-alanine residue from the cytoplasmic disaccharide-tetrapeptide GlcNAc-MurNAc-L-Ala-gamma-D-Glu-meso-Dap-D-Ala, which is a murein turnover product. Probably also act on free tetrapetide. May be involved in murein recycling.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSRPSSDQTWQPIDGRVALIAPASAIATDVLEATLRQLEVHGVDYHLGRHVEARYRYLAGTVEQRLEDLHNAFDMPDITAVWCLRGGYGCGQLLPGLDWGRLQAASPRPLIGFSDISVLLSAFHRHGLPAIHGPVATGLGLSPLSAPREQQERLASLASVSRLLAGIDHELPVQHLGGHKQRVEGALIGGNLTALACMAGTLGGLHAPAGSILVLEDVGEPYYRLERSLWQLLESIDARQLGAICLGSFTDCPRKEVAHSLERIFGEYAAAIEVPLYHHLPSGHGAQNRAWPYGKTAVLEGNRLRW
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTQQETLTDGNALKQFVVLAKSSKGRAIVSIIEKALNHPSVFVFGELLDMPNVQQLKETEFKNYYDLLLIFAYGSFIDYKNKKDSLPQLTPQMITKLKQLTIVFLSSTSNVIPYSVLQEQIEITNVRELEDLIIDSIYQNIIKGKLDQKNKHLEIDFSIGRDVQPEQLDSMINCLNNWSSTSQKLLDDISGLITHSDKVHLQYRKEKEEFESKFEIAKLNTKNDSPAEQLYYDSMEYSDEVRMKKGPKIKGKDYNKRP
The following text describes a protein:
Function:
Essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for NF-kappa-B (Rel) activation. Required for antibacterial immune response.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDEESFVILGSSPCSSLMPDSSLRSDVCGNAQEAEETVASTSTQPPTVNCIPVSITASQQQHKSLDSGSSQQQSLATSFIMGEIQSDVLKNSVYSQFPSLCSLQGSAEEVVKLQNMMTEYLALKSTLDKVNQTMLNYHNLTQQWRQEAADREHQYKEHVKECQAQIAILRVENQELKRDLETKIEQIEGVHTIRLKEQDELRKSVSEKQSLIDNMRVEIDKLKQLNHSFEFVPEYATESKSQELIKKMQLDINELKARDIQKQEVIKGLQIQNDIYRRDFEMERADREKNAGEKDQYLMDLRSLQRRNQELIEALAESHKASKACSTASPLSSSRSNLREEQRPILDPTGASSRTSDTTLRCPICSKSFNALSVLQSHVNDCLDKN
The following text describes a protein:
Function:
Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLINIEGIQAFCQTIRNPRRIIPHATFPTFSQIPCNINYFLEQKFQVPVDIRALVLDKDNCITLPNETTIAEAELKKIREFQNIYGEKNVILLSNSIGTRKLDPTGELAAHFQQKWNIPVVRHSKLKPLCTEELYTYLSNNSHVSSASQILFIGDRLLTDITLANIMGSWGVWLTRGVGNTTNMMMEVESWLYKRIHTQNPYIPTNRKS
The following text describes a protein:
Function:
Catalyzes the first step of the biosynthesis of Kdo8N (8-amino-3,8-dideoxy-D-manno-octulosonate) from Kdo (3-deoxy-D-manno-octulosonate).
Miscellaneous:
MISCELLANEOUS: Kdo8N is found in lipopolysaccharides of members of the Shewanella genus.
Sequence:
MSFKNFKVVEKMIFGRGSFVQLDDVLAAQRKADDDFVVFLVDDVHQGKPLEARIPVKAQDLLIWVNVDEEPSTIQIDALTEQVQAFNGKLPVSVVGLGGGSTMDVAKAVSLMLTNPGGSAMYQGWDLIKKPAVHHIGIPTISGTGAEASRTAVLCGPVRKLGLNSDYTVFDQIIMDSELIDGVETDQWFYTGMDCYIHCVESLEGTFLNEFSKAYAEKAMDLCRQVYLEDHPEKDDKLMMASFMGGMSIAYSQVGACHAVSYGLSYILGYHHGIGNCIAFDVLEEFYPEGVAEFRLMMKKHNITLPKNICKDLPDETIAKMVAVTKSMGPLWANVYGPTWEEKVTDEMLTALFRRI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADDRFTLPLRPLIEKRDRPDPLPLEIAQINAQWGSFRDVSEESLRAKIEEEKSKEYTIEEEEGEGAGAELDTTERLDQLYKRRAEIIQFAMQAHMEAMFALDFVSMLLSKHTPRQAETSMSAYLKQVAPLGSLHSEIINPPPKSEAVVRDTKTVSRGWRLQSFNAAADKLLKSASRLENEVASETRYWHEVLAVKDKGWKLCRLPRQGQTLGVQYGFLEATPIFRDRGLAALRRSEDGTLILDKGLVPTKAKTVRVRVKDCGIITGCSKPYRSAAQDPDSIEGRILQARDTLYEEELFHELFREARIMGSQGVTTRQNLVQFPVSEEQEILLDLVDPDQEVYVDDEATKSEEHNVLADALAHLIRILLCYAHRQNLRRRTQPPPALSPKRRHIPEYQLLRPIMAYLQHSFHVRWLETFMKDVYGVLQSAGLSCSFTATPYSSVNLSNIDRSVPKVEGLIRQFLLPLESTFSADLLTPQSSFKVKSRTNLSVPPFGTQFEILLNLPHYPDVHPPHRIGLHDQAANIITHFIMLDIVAAIELQTSPALSISKTEAKSVSWEATYPHHGELLSVSIDGKQKKMKVILSRDELTIQTYDVLGLERYSRAAPETTPGLQTHTWKAGPTTAPSLMEYVAAVSQR
The following text describes a protein:
Function:
Methylates ribosomal protein L11.
Subcellular Localization:
Cytoplasm.
Sequence:
MLVYLLPGSFDTREAHLDLLWEAGATGLEERGPNIRVYFDERTELPAEVADGEWHEEAEQDWQAEFKKNLRPVHAGRVTIVAPWQREEVPAGQLALVIEPGMAFGTGHHATTRMAVEALGELDLSGKRVLDVGTGSGVLAMAAAKLGAAQTLGVDIDPITIPIARDNARDNGLTSGIRFEEGTLGLDEDAEMFGEPYDVLVANLYAELHDLLAGEYAAQLRPGAPLILTGILTSKLPLVRDALDREGFTDVQVRTDSEGAGGEWALVTARRED
The following text describes a protein:
Function:
Regulates the dynamic behavior of MamK filaments; paralog MamJ also promotes MamK turnover. At least one other protein besides MamJ and LimJ is required for MamK turnover. Might connect magnetosomes to MamK filaments (Probable).
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 20 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)).
Subcellular Localization:
Magnetosome. Note=Tagged protein extends in a line from one pole to the other.
Domain:
The center of the protein is Glu- and Pro-rich.
Sequence:
MMMEHEMATNRRPRAKRTPGDKLGKGGGDAALAPAADAEIPASSAPEPAAPISAPPAPVIKPVGGDAWASLLSGSPWSSPGAASPTEAALKPVMPSALAEAVANAPPEAAPFTELVSHWSPPFRRQPDREYEEINPAEAAIPVTAAAPEPEPEPVPEPEPEPEPEAAHDHAATETEGVTEMMTSDVELEIEIASDVEVVEAPAVIEPSPRPQAFSHSTAYAYPAEPAPAVETAAEAAPAGPAENPVKEVPVEDLFTGIFNVADSAVRGAIGASTDLLRDPKSLGGKLSVAGQSLVHSIKGRFNALLAPRHGAKSNGDEF
The following text describes a protein:
Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MIKLKVYQVTIDTETEKSDIKSAVFEKAKELSTEDLNNLLSAVHTVSQNSNSKYDEHHANPRNMGENLSISASSNSINIQSLGDNDTSYDQLLEKYLKMDPDLERELVLRTMRDNMLMEEAKAIDPTYLEDLNSSSLNYEQEIPDPTEMGRQSSGFYSPHFPRDILHQEDGYKKGQRSLAMDYENEDFPRYDKAQNIGFTRRNERNISPRFYNQNKSHDEFNERKRDNEYGENSNIHNFTGFNNRTPKTNEKNRSFNSWRRDIDTANCTFKQKTSAPKLCRPVSRTSAEDILCLPGRLSRPKKIAVILRGLPGSGKTYVAKVLRDKENEHNISSRVLSLDDYFITESEKSVKDPDTGKMVKQKIFEYEHEPEMEQTYRASLLKSFKKTLDDGFFTFVILDSINEKVEHFFEFYQAAEQHGFNVFVAELQSDVDVCFNRNVHKRTRKEIEALQSVWQETPPDLKQLDLSFFIKNSQITEVNMEDASDTEGDIMKTNLSPVDQQLVEVPKSKWENESATAKLDQLDGIKKSVAIKRSMEDFLSVTDDYNSRHSAPGKKRVRWADIDAEESQKRMREVGFVVGQTNWTKMMDKGQGQKALNQTKLF
The following text describes a protein:
Function:
Monovalent ion-dependent bioluminescence photoprotein. Displays an emission peak at 470 nm (blue light). Trace amounts of monovalent ion trigger the intramolecular oxidation of the chromophore, didehydrocoelenterazine, with the emission of light.
Miscellaneous:
MISCELLANEOUS: On the 2D-gel the determined MW of this protein is: 60 kDa.
Sequence:
YVRPVSSWKVAVFEHQVIPPKTDMETREEALDALKLNSDVYHEAVLESRSKGVKMIVFPEYGLYDINTLTRTRMDLMAEKVPHPKHGHRNPCDEPEYQTQSSEMLRTFSCMAKENDMYMVVNMAGREPCRRATEPECPGDKQLLYNTNVAFNNEGDVVARYYKTHLFWEEGWFNSSKNYEMALWDTPIGKFGTFMCFDFQAVQLIEQYNVRHIAYPASWVNLPPIYQSIQSHSAFARFAKINLLAASVHRLETSTYGSGIYSPNGAEIFYFRPDIPKSKLLVAEILPIHVKKPEQTVVNFDNPVFPSEDDDVQDLFDRGDFAFLKYKRMTTRAGTVEVCQKSFCCKARYAVKDRFKEVYAVGVYDGLLSAGANNLYFQICTVIQCPHKKCGLKISKVRTHFKYLNLRADGWLDRYVFPSYTVMYNNYIALDPFVWNYTEAGGIETKPGTSTPLHSANLVARIYAKDSSKHVHQSHPIDEGVIKMAVKYMLYVMAAYVYAAS
The following text describes a protein:
Function:
Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism). Deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage.
Sequence:
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI