lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-AG), and thereby regulates the degradation of endocannabinoid-related monoacylglycerides. Also hydrolyzes arachidonoyl ethanolamide (anandamide, or AEA), but with low efficiency. Plays a role in the regulation of longevity and resistance to oxidative stress.
Sequence:
MGNNFWSTWSPSQRIFSLIWPATILYLIMKLLIEKMWGKNRGAVERFQTRREALFDDFKSRSAPASLVNNPRIVKGNETAEQIETTFNEILKLDLIALKSALQTDKYNAYTVLCAFVWRAIDVNSEINCITEVIREAFNTAEALDDNYAQTGEKGQLFGLPFSVKSNFYMENYDVTVGLAKLLEQPKTTTCPMVQFLSDQGAVPFCLTNVPQGLLSYVSSNPIYGTTKNPWDFSRTPGGSSGGEAALLAAGGAAFGIGSDLAGSLRIPAAFCGLVTLKPTQDRLCVTDTHGGLPGRGRLGLSFGFYTRSVKEQEFLLGLIVGRSEYLELCPMSSPAKLEKHIEKDQKLVIGWFVDDGFNPVVPSNRRAVEETVKSLQAKGHQVVELKLADVSEEFPPFAVADMLFRNVMPDNGAYMSEMYAGEQYDEHMKLFIRLVCLKQNFLVSFLLRYGVMPFAKLALSKRLACIGSAYNSDLAACRQNQENTDSYKLQWIRYWKSKKIDALICPSFITPAQPFEYPAQLSNGAFITGLFNMLDVPAGVVPVSPVNQKDVDQLIDGFSTEGDLLLKKQREAARGTTGLPNAVQVVTLPNCEEMCLRVMRLVEESAEGVQRLQWRVGASAAPIDVENTPAGVVSSLEHFERVNLLH
The following text describes a protein:
Function:
Required to establish the unique cell identity of photoreceptors R2 and R5 and consequently for ommatidial assembly in the developing eye imaginal disk. Repression of expression in R8 photoreceptor by senseless (sens) is an essential mechanism of R8 cell fate determination (By similarity).
Subcellular Localization:
Nucleus. Note=Restricted to nuclei in the developing retina.
Sequence:
MLQQNPSSPLHAEQFIKSSNSTPTATPAPASATATAPIHTVLATPQRPSSPRQFFERLYGHLETRTHNSESGDIDVGTHAETPYQSDGGSASSPDISISDERVSLVSFPSYELHAPTPDYSAYGAIANATLPPALSFPAFSADPHINAGFSAFLARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLSETQIKIWFQNRRAKDKRIEKAQIDQHYRNFVVANGFMSTIMGQTSYATSAPATSSAAATAAAMLGSSYYAATPALLPSTLVNNARRADVNYVDIEAQHQQQQQHHHQVHPDQQQQQQQQQQRRSRFVPPPTLINSC
The following text describes a protein:
Function:
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Subcellular Localization:
Synapse. Secreted. Cell membrane; Peripheral membrane protein.
Sequence:
MAPLFLLLLLLLSPSPTSAHRFAYSAPNRPEVRTTTGSVRGLLIPAGPSGSTAAAFLGIPFAVPPLGPLRFRPPLPIPTPWTGIRDADSQPFACYQMVDTTFPGFQGSEMWNPNREMSEDCLYLNVWTQKGDPTEPPVLVWIYGGGFTGGSVSLDVYDGRYLAAAEEAVVVSMNYRVGSLGFLALAGHRDAPGNVGLWDQRLALQWVRDNAEAFGGDPDLITLFGESAGAASVGFHLLSPHSKGLFRRAVLQSGSPNGPWATIGAAEGRRRAAALGRAVGCPYGNETEFLGCLRGKEAADVLEGEGVVMPPQSVFRFAFVPVVDGDFVVDSPDVALWGDYGVKGGEGGHGVEGGDGGYGVKGGDGVKGGYGGGYGARGVREGDGDGGYGVKEGLREGYGVKEGYGVEGDGANAYGARVPPRPHRDETPPDAYGAKGSADAYGAKAAPRPHRDETSPDAYGAKMPPRPHRDEASPDTYGAKMPPRPHRDETSPDAYGAKMPPRPHRAGGEVEVLLGAVRVEGSYFLVYGVPGFGKDNESLISREEFLGGVRMGVPQATELAAEAVVLHYTDWLDADNPVKNREALDDIVGDHNVVCPLMAFAQRWAQRGGKVYAYLFDHRSSTLLWPSWMGVPHGYEIEFVFGLPLEPRNNYTREEVELSRRIMRYWGNFARTGDPNGGVGGPRWPPYTPSGQRYAHLNARPLSVGHGLRTQICAFWTRFLPKLLNATGPPEDAEREWRLEFHRWSSYMGRWRTQFEHYSRQQPCATL
The following text describes a protein:
Function:
May be involved in defense against water stress.
Sequence:
MSSQQNQNRQGEQQEQGYMEAAKEKVVNAWESTKETLSSTAQAAAEKTAEFRDSAGETIRDLTGQAQEKGQEFKERAGEKAEETKQRAGEKMDETKQRAGEMRENAGQKMEEYKQQGKGKAEELRDTAAEKLHQAGEKVKGRD
The following text describes a protein:
Function:
Probable beta-1,3-glucanase that may be involved in the degradation of callose walls around the microspore tetrad during pollen development (Probable). May be required for pollen exine formation.
Sequence:
MSLLAFFLFTILVFSSSCCSATRFQGHRYMQRKTMLDLASKIGINYGRRGNNLPSPYQSINFIKSIKAGHVKLYDADPESLTLLSQTNLYVTITVPNHQITALSSNQTIADEWVRTNILPYYPQTQIRFVLVGNEILSYNSGNVSVNLVPAMRKIVNSLRLHGIHNIKVGTPLAMDSLRSSFPPSNGTFREEITGPVMLPLLKFLNGTNSYFFLNVHPYFRWSRNPMNTSLDFALFQGHSTYTDPQTGLVYRNLLDQMLDSVLFAMTKLGYPHMRLAISETGWPNFGDIDETGANILNAATYNRNLIKKMSASPPIGTPSRPGLPIPTFVFSLFNENQKSGSGTQRHWGILHPDGSPIYDVDFTGQTPLTGFNPLPKPTNNVPYKGQVWCVPVEGANETELEETLRMACAQSNTTCAALAPGRECYEPVSIYWHASYALNSYWAQFRNQSIQCFFNGLAHETTTNPGNDRCKFPSVTL
The following text describes a protein:
Function:
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
Sequence:
MGNADLRQLAAIEETPFADLEGSVVAVDAHNWLYKYLTTTVQWTGADVYTTSDGTEVANLVGAVQGLPKFFEHGLTPVFVWDGGVTELKDDEIADRREQRERYEEQLDDAREAGDAAEAARLDARTQRLTPTIHETTRELFDLLDIPQVEAPAEGEAQAAYMTRTDDAVDYAGSDDYDCLLLGSPVTLRQLTSSGHPELMDFDATLAEHDLTWEQLVDVGILCGTDFNPGIDGFGPTTALDAIGEHGDLWDVLAAEGEHVAHGDRIRELFLNPDVTDDYVIDPDVSPAIDAARAFVTDEWEVDADAVARGFERIDAAAAQTGLDRWT
The following text describes a protein:
Function:
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex.
Sequence:
MSTFVPKLSSGSTVKIRFNTIELGGTKWKEGTFEILEKDNRVNLCLRFSCGGAAKTFQLNHNVKSISQNPNRIMLTLKDNVVIYLDKMPQPLVQRTKEYLEKLKQGKSVLKSSYGSANLSVLGNRSMKNETNVSGERQTTPRRQSIEGREDTTPRKPLSSPSRAAATPTRIGLLENRGEKRKRLLTSESDLNEDYPKENDSSSNNKATSETPRKFLLSCKEKLKLSEENRSAGPLAASPLQPTSFYGSRSVTKDYSQSHSFVDRPVSTSQTTPAKRSLILPNHSTPFKKVRPSLEYGGWNKQRPSALAQPQPPLQGFSNLGNTCYMNAILQSLFSLPSFSNDLLKQSTFWKNLPINALLRRFAHLMIKKDVGCPETKKDLLRKVKNAISSTAERFSGNMQNDAHEFLSQCLDQLKDDVEKISKSWSNGAAPPASAASELGQESTAVKAEPAEEADTSHIFTCPVVANMEFEVQHTITCKGCGEVVTKREQFNDLSIDLPRRKKTIPLRSIQDSLDLFFRMEEIEYSCEKCNGKAATVAHKFSKLPRVLILHLKRYSFNAQLSLNSKLGQQVVIPRYLTLLSHCTESTRPPVSLGWSFPASVRFGGKAAFSNSSCVLLDSDCEEELNRKVSTSHKRHDGFQRGAMESGDFSGINDDEMLAAVLEMSRQEAGLSAPPPLEDEPTSSPDTGFGDSDINDLTYHTDQLEGDTKQSADVLGSLDMTMDDNKENQTPESVQQQGELDWVQQYNLDQEREEQELQQALAQSLQEHEAQEMREDDDLKRATELSLQEFNNSLPELLCSDEDSGNEDVLDMEYTEAEAENLKRNAETGDLANSYRLISVVSHIGSSSSSGHYISDVYDMKKQSWLTYNDLDVSRTQEAAVQRDRDRSGYIFFYMHKDVFEQLSEMERSGASGASEAVRNVLQPL
The following text describes a protein:
Function:
Involved in oxygen transport from gills to the various peripheral tissues.
Sequence:
MFEWTDAERSAITSLWGKIDVGEIGQQALTGEHLIMYPWTQRHFASFGNLSTNAVILGNPKVGQHGKVVKWAGERSEEHGQHQEHLHKAQNSTWILTTSGYVINVQLLSFFLTIALYETTNALAECITVCITAKFGPQVFTVGEQEAWLKFLSSGRLFHKRGPQC
The following text describes a protein:
Function:
Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting.
Subcellular Localization:
Cytoplasm. Note=May be loosely associated with the inner membrane.
Sequence:
MNEFKRCMRVFSHSPFKVRLMLLSMLCDMVNNKPQQDKPSDK
The following text describes a protein:
Function:
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Subcellular Localization:
Cytoplasm.
Sequence:
MDFITINSSNKTEEFALKQVAKQATSSLLYRLGKTIILASVCVEREPVSEDFLPLVVQFLEKSYAAGKIPGGFVKREGRAQDFEILTSRLIDRTLRPLFPKDYRYPTQITLMVLSHDIENDLQVSALNAASAALFLAHIAPIKSVSACRIARMDNEFIINPSASLLNQSSLDLFVSGTKESLNMIEMRSLGQKLNALEEPLMLEALELAQKSLEETCTLYEEIFTPHQNELFFKESQGIVFNERLLDLLKNQYFDEIIKGIESSALSERENVFNEIARKISEAHSEFSLEEIELSLEKVKKTEIRRMIIKDKIRPDKRALEEVRPILIESDLLPMAHSSILFTRGQTQSLVVGVLGTDNDAQTHESLEHKAPIKERFMFHYNFPPFCVGEASSIGAASRRELGHGNLAKRALETSIKNKEQVIRLVSEILESNGSSSMASVCAGSLALYASGVEIYDLVAGVAMGMVSEGQDHAILSDISGLEDAEGDMDFKIAGNLEGITAMQMDTKMSGIKLEILYQALLQAKEARKHILKIMHEAKEKIVINFSHLPTTEIFNVAPDKIVEIIGQGGRVIKEIVEKFEVKIDLNKPSGEVKIMGNKERVLKTKEFILNYLHSLDQELEQYAIDEVLEAQVKRIVDFGAFLSLPKGGEGLLRKQNMDKCQVVLKEGDSIRCRVISFNKGKIALDLA
The following text describes a protein:
Function:
May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.
Sequence:
MLEKEGKLIMSREDEEIMAWFERTTRDAADVQRETLRRILAENAGVEYLRELGLAGLTDAGSFRARVPVVTHADLDPYIQRVADGDASPVLTAKPVTAISLSSGTTQGKRKRLLFNDDLLRSSIRFFHASYAFTNRAFPVEDGRVLQFMYGSRHETTKGGLTATTVMTNLLRSEEFTASMAARSRPRLPSCSPSEVVFSPDFDESLYCHLLCGLLLAGEVRAVSASFAHSIVVALQALERVWRELCADIRRGAASPARVTTPAVRRAVAPILAAPNPALADALERRCAALGDWSGVIPALWPNARYVQATMTGSMEHYVKKLRHYAGGVPLVSGNYASSEGVIGINAEQHAPPESVVFTVLPDAAYFEFIPLKPPCTDAAADDDNPAAAGSSCYVDADDANPVGLTDVVVGEHYEVVMTTFTGLYRYRLGDVVKVAGFHHATPKLRFVCRRSLILSINVDKNSEHDLQLAVDSAAKILAGDGENHKQLEIADYTSHADTSSDPGHYVVFWELNGGGEEDGGGVLQRCCDEMDRAFGADAGYAQSRKTCAIGALELRVLRRGAFQEVLRHYVAGGSSAGQFKMPRCVAPSNAGVLRVLKDNTINIFFSTAYDYD
The following text describes a protein:
Function:
Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.
Sequence:
MKSFRAANALLRTNPAASNAISRIAAPLVTVSGSPVCQCLLTTSRTTLPQTPLTVRPFSTTPTRPGKKDKKSKRGEEVEEPPARGGKKDKKGSKSSSSSSKDNSPAEEQPNDPKDPNRPIPSPETPYDLSDLTYAFDRADKHYLDALKTFRSGSRFSADSIGSLPIFPDKKDTSLSYPLRDLATVAQVSGSGRKWSILCFDESSVKPIMSAVQKSPDFNQQPQRSEENPLELTITVEPERAEDLQKRVKELCQLWREKLRAETHKREAVHKKWKQQEKILDDDVKALKTKVQKLQDERMRGVAVREKEVCNAVMARK
The following text describes a protein:
Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Sequence:
AKPCGGCLSREAHTQVHVFRQELFQEAKELLYRFLPQKIIYPHSCLTSLRAPLDIPIPEPPPKDEVETERQEKKEVLECGFLPGNEKVLSLLAMVKPEVWILKEKCILVITWIQHLIPKTEDEKVLERVNAVKTKVQAVQTTISKYFSEHGDAVAKASKETHVMDYQALTAYGEVKARVLDLKAFCAELYHIISTNLEKTKPSVY
The following text describes a protein:
Function:
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
Subcellular Localization:
Nucleus.
Sequence:
MKEVSVCFHSAMWMHPDNDPLAPGFFPESLEHHDQAPAGPAARAALPDDDQVQSPPSPPLPSLLSAGGIKVRPLTACPLLLQLHRPRCFHGPAASCPAAHHQRGDPGRLWEVHEGVQMGPVGLGGLPPQGVTRGRKPKKPLLSPSLPVHPSGPGGTRDTQDTQAPSTLTSRSWVRGQCSPRLSLEGPLWEDPVGPEERLLGGPFLNRCPVPKFFQKAAGNVRENTGEDLDTEQLIHETCRNCLEQAKLLFCDGKKSVARLPHEVPVMKRARPAEEDTSQQQGSPAPKKRKGRPPGQSQLSSLKPVAVNMGKSKSCEPAQREGPKWDPSRITESTYFVLGSRANKALGMGGTRGRLYIRHPHLFKYAADPQDKHWLAEQHHMRATGGKMAYLLLEEDIKELAASEEYRGSLELKLDELKPFTAPPWMAQKMRMAMEALRCGGEGEPPPPPKDA
The following text describes a protein:
Function:
Functions as a receptor binding protein (RBP) and probably mediates the attachment to the host capsular exopolysaccharides. Displays a depolymerase activity that specifically degrades the K56-type polysaccharides of Klebsiella pneumoniae capsule, which allows the phage to reach the host cell membrane and bind the entry receptor.
Subcellular Localization:
Virion. Note=Tail appendage (Probable). Depolymerase 1 is connected to the phage tail via an N-terminal anchor domain, while depolymerase 2 is attached to depolymerase 1 (By similarity).
Sequence:
MLKTDFNQPKGSTIGVLRDGRTIQQTFDKMRYADTIQELRTMEPVGPRDVATVRRATEDSVLVNAPVYYDKNDTTSPDDGISVFVTAGGARWKFNTFKGYCAGLAGLKEDGSNVTTVVNGIVNRIVAKMVAAGRVNNQQRTVNIPVTGDAPEWKLTGPLVWPTVISLVFHGSVLLDGTSLTAGKILNCNNVPFMDRLTVAIMAAGTNPTDRPGRVNQAVGRAALTCIGGEVTVRLPGTQMDGSNNPTIHTVGAMIGNDAACLLDARDIYFEKFNIIGAKTGIEFGCYNTFMCGVEHFNVSRCYDGFSSPTLGSNYGERMYLRNGTIGNMDRHGAYLVGGGDFTLENVSVDFLGGDLAHFGPLSPAEYKHLSGHIEGVKGSLAAKEMPASYSKALVILGKAVRRDDRVVDQNDYRGVRQLFACPQNPYGRMLKVINESYAPGREGQVPNNPYPCETGWPGNSGVELILPKDTFVDTPYVNSYSPAVRNSVNQTISFTTASTGPLGGNVLSTDYAFAAEIIGGATCSYGTPAEATSDGYMPFIITLSDPSDVVYLFCTNRFRPGSGQSVLWGNCSVTLVGTTGSIILAPVIASYLGTTWTANTTTGAVTATPIRRGIQEGGTVDMSALAAAGGIPNGTYQAMPSRSVQGFYLGCDHAVAGFKITGGTGQVRLKLPVWWFR
The following text describes a protein:
Function:
Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MRILLKPFGFSRLLQAEWCYLSESILLFTLVPRLRKASTNFLLGQRQGFSTMPEAEASVRDRELFSPPSDVRGMTKLDRTAFKKTVPIPVLKARKEVVSRLMRALRRVALQRPGIKRVIEDPKDEDSRLIMLDPYRMLTSDSFEKPELSALKELDVNPQLSQYNLELTYENFKSEEILRAVLPEGQDVTSGFSRVGHIAHLNLRDHQLPFKHLIGQVMVDKNPGITSAVNKTSNIDNTYRNFQMEVLCGEENMLTKVRENNYTYEFDFSKVYWNPRLSTEHGRITELLNPGDVLFDVFAGVGPFAIPAARKNCTVFANDLNPESHRWLLHNCKLNKVDQKVKVFNMDGKDFLQGPVREELMLRLGLSTEGKPSLHIVMNLPAKAIEFLSVFRSLLDGQPCSTERLPIVHCYCFSKDSDPAKDARQRAEAVLGVCLEASSSVHLVRNVAPNKEMLCITFQIPTATLYRDQALGLQNDQEPPLKRQKTGEPFSGEPQSASDS
The following text describes a protein:
Function:
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, perinuclear region. Cell membrane, sarcolemma. Sarcoplasmic reticulum. Note=Localizes to centrioles and deuterosome. Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular pattern within the sarcoplasm (By similarity).
Sequence:
MDQRPELLSSMEYVASPDPKPGVPLRVAENVAPGAEDWLPSASGHLAWATSLETEHQTHLELSEEQRLQISKELVDLQIATHHLREQHEAEVFELRREILRLESRVLELELHGNGACQGHKVQPMANLGQHQVPPLEPPGGQQKLQEELKWLLEHHRARQQALETQVGVLSQQLQGAREEARTTGQQLASQAMVLASCKGQLRQAEAENTQLQLQLKKMNEEYAVRLQHYARETVENASSTNQAALQAFLESTLQDIRAAHRTREQQLAQAARTYRKRLADLNQRQELLLTTCRATFATAINLEPLPMHWATELSHPRENEYGRHRTLLLYPEKGSGETSKENKSQPLALDTASWAQIQQRLQDFSQDTQAELERERAQLMVRATMAEQQLSELQEYVDQHLGRYKQEILKLRKLVNIGDPQGVEAVSSPGSGGARL
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGCLCGHEDEEGHNGAHPPAPAPAKDVFAENRKCRDVLFLILFVAFWAGMFYVGGTAFNKGDPNRIIYGLDSQGNLCGQKNAGVNGTGGPDLSNKKRLYWLDYRDIVGGNITRSKRVCVADCPANSTEFVCAYNGQYETDYFNMLSIAGKLNSALGSGPCYPVLLPTVSVLNKCFPQAPPGLTAFVNGAVNASAAAPSSTVSANATVDFEFVASMAANLSKNKLQAYISDLIKAWLVVLVCGVGGGVLFSVLWIAVLRFCAGVMAWTSILLVNAALVGCTLFCYAKAGKLNGQAIAQDLGRDLPAALNPSTEDRHVFLVVAYVMTGLSVAMLVITGLLFRRIRIAVACLKVGSQAVAAMPLLMLFPALPFLLLVALLAYWVAVAAFLYSAGDIVHAADGSYSIVWDTTLRYMAVYHLFGLLWTWQFIAGLGYCVVAGAVASFYWCRGDRSRVPRCPITLAVKRTAWYYLGCVALGSLIVALVQFVRLLLEWVDRKARSVTGGGGWLAYVMGCLRCVLWLVQKIVQFINKNAYIMVAVKGTGYCDSAARAVALILSNAVRVAAVNTVGASLLWVGKVAVAALCGGFAFLMCDLPQYAQPDRPAYLSSPLFPVLFSAVFAYFIAAVFMNVYEMAIDAVLLCFCEDCERHDGDPQYAPPLLLTALGKAAHKETTVVPSAPPALAPPAPPPTAYSYSPSSPGPLQPYPPGVPPPMQGGWVAGPHGSMMSAPHRVQAGQGVYGYTGR
The following text describes a protein:
Function:
Receptor kinase that detects X.oryzae pv. oryzae protein Ax21 to promote innate immunity. Following X.oryzae pv. oryzae protein Ax21 detection, undergoes cleavage, releasing the processed protein kinase Xa21 chain; The processed protein kinase Xa21 chain released by protein cleavage after X.oryzae pv. oryzae protein Ax21 detection translocates into the nucleus where it can bind and regulate WRKY62, a transcription factor. Confers resistance to the bacterial pathogen X.oryzae pv. oryzae (Xoo).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MNLYMLKQTSLLLPLLLCCVCNTVRCSAAPDTNTSAETDALALLEFKRAASDPGGALSSWNASTSLCQWKGVTCADDPKNNGAGRVTELRLADRGLSGAIAGSVGNLTALRVLDLSNNRFSGRIPAVDSIRGLQVLDLSTNSLEGSVPDALTNCSSLERLWLYSNALTGSIPRNIGYLSNLVNFDLSGNNLTGTIPPSIGNASRLDVLYLGGNQLTGSIPDGVGELSAMSVLELNNNLLSGSIPSTLFNLSSLQTLDLGSNMLVDTLPSDMGDWLVSLQSLFLNGNQLQGQIPSSIGRASELQSIHISANRFSGPIPASLGNLSKLSTLNLEENALETRGDDQSWGFLAALGNCALLNSLSLDNNNLQGELPDSIGNLAPGLQVLRMGFNNMSGTVPPGIGKLRNLTTLGLSHNRFTGVLGGWLGNLENLQYVDLESNGFTGPIPPSAGNLTQLLALKLANNGFQGSVPASFGNLQQLAYLDLSYNNLRGSVPGEALTSPRMRTCVLSYNSLEGSIPLDFSRLQELTELSLSSNAFTGDIPDSIGQCQMLQTVEMDRNLLTGNVPVSFGNLKSLSTLNLSHNNLSGPIPSAALTGLQYLTRLDISYNDFTGEVPRDGVFANATAVSLQGNRGLCGGATTLHMPSCRTRSNKRAETQYYLIEVLIPVFGFMSLALLIYFLLIEKTTRRRRRQHLPFPSFGKQFPKVTYQDLAQATKDFSESNLVGRGSYGSVYRCRLKEHGMEEEMAVKVFDLEMPGAERSFLAECEALRSIQHRNLLPIRTACSAVDNRGGMFKALLYEFMPNGSLDTWLHPRAAPPAGGGKAPKRLGFSQRVNVIVNVADVLDYLHHECGRPTVHCDLKPSNILLDDDLNALLGDFGIARFYADSKSAPPPAVDDPTSSVGVRGTIGYIAPEYAGGVRLASTSGDVYSFGVVVLEMVTGKRPTDPTFKDGLDIVNFVSSNFPHQISRVVDPRLSEECKEFSRDKVEPENAAYQCLLCLLQVALSCTHPSPSERVSIKEVANKLHATQMAYEGAKEKK
The following text describes a protein:
Function:
Transcriptional regulator.
Sequence:
MSAEKISISLPKELYRELEDFIIRKGIPDRSKIFQIALRNYLDENRDGNEIIYGIINLVYDHEEASEALTEIQHEYNDSIISTLHLHVSEKICIEAIAVKGEKRKLVELNNKLGQIRGILKARLLISFPYEKT
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. Controls exit from the prevacuolar compartment (PVC) in both the forward direction to the vacuole and the return to the Golgi. Allows VPS10 to return to the (trans-Golgi network) TGN from the PVC. Might also function as an alternate adapter in the COPIb clathrin-like coat.
Miscellaneous:
MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes; Both IUM domains are necessary for efficient binding to ubiquitin.
Sequence:
MSVSTPSELDALIEQATSESIPNGDLDLPIALEISDVLRSRRVNPKDSMRCIKKRILNTADNPNTQLSSWKLTNICVKNGGTPFIKEICSREFMDTMEHVILREDSNEELSELVKTILYELYVAFKNDSQLNYVAKVYDKLISRGIKFPEKLTLSNSPTAMFDSKTPADWIDSDACMICSKKFSLLNRKHHCRSCGGVFCQEHSSNSIPLPDLGIYEPVRVCDSCFEDYDLKRHDDSKKSKKHRHKRKKDRDYSTPEDEEELIRKAIELSLKESRNSASSEPIVPVVESKNEVKRQEIEEEEDPDLKAAIQESLREAEEAKLRSERQKASRQMQPQQPSPQPQPIHSVDLSDEEKDSIYMFASLVEKMKSRPLNEILEDSKLQNLAQRVFASKARLNYALNDKAQKYNTLIEMNGKISEIMNIYDRLLEQQLQSINLSQQYTLPQVPSDPYNYLTENVQNPAESYQTPPLQQLSSHQYKPQQDVSRQQSVKANSSPTTNIDHLKTIDVTPHAQQKPQSHVELAPSDPPYPKEEAEDEGTQAVQDEESSTQESRERPYPVETENGETSINKRPQGITRYDFPTVPARKFVQPESTVPLPASSSEIPIKEERPPSPQEELLIEL
The following text describes a protein:
Function:
Transcription factor that plays a key role in neuronal differentiation. Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (By similarity). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Preferentially binds to DNA binding sites that are in an open chromatin configuration.
Sequence:
MDVDAEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECYESDGTEDMDDKEEDDDEEFSEDNDEQGDDDDEDEVDREDEEEIEEEDDEDDEDDDDGDDVEEEEDDDDEEEEEEEEEEENEDHQMSCTRIMQDPEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENISDRSYAEGMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQDRSQPPNMSVRQHVRQEDDFPGRTPDRSYSDMMNLMRLEEQLSPRSRTFSSCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMDAGRRDNLRSYEDQSPRQLAGEDRKSKSSDSHVKKPYYDPSRTEKRESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHENVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSNQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKNASPSSSTTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCTARNPDMEVDENGTLDLSMNKQRPRDSCCPVLTPLEPMSPQQQAVMSSRCFQLSEGDCWDLPVDYTKMKPRRVDEEDPKEITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQVTITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV
The following text describes a protein:
Function:
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Miscellaneous:
MISCELLANEOUS: The sequences from strains C3H, CBA, DBA/2 and FVB/N are all identical to the one displayed; MISCELLANEOUS: [Isoform 1]: Binds IL-4; MISCELLANEOUS: [Isoform 2]: Binds IL-4; MISCELLANEOUS: [Isoform 3]: Lacks the cytoplasmic domain. Binds IL4.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted.
Domain:
The extracellular domain represents the IL4 binding protein (IL4BP); The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation; Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Sequence:
MGRLCTKFLTSVGCLILLLVTGSGSIKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRLPLGVTISCLCIPLFCLFCYFSITKIKKIWWDQIPTPARSPLVAIIIQDAQVPLWDKQTRSQESTKYPHWKTCLDKLLPCLLKHRVKKKTDFPKAAPTKSLQSPGKAGWCPMEVSRTVLWPENVSVSVVRCMELFEAPVQNVEEEEDEIVKEDLSMSPENSGGCGFQESQADIMARLTENLFSDLLEAENGGLGQSALAESCSPLPSGSGQASVSWACLPMGPSEEATCQVTEQPSHPGPLSGSPAQSAPTLACTQVPLVLADNPAYRSFSDCCSPAPNPGELAPEQQQADHLEEEEPPSPADPHSSGPPMQPVESWEQILHMSVLQHGAAAGSTPAPAGGYQEFVQAVKQGAAQDPGVPGVRPSGDPGYKAFSSLLSSNGIRGDTAAAGTDDGHGGYKPFQNPVPNQSPSSVPLFTFGLDTELSPSPLNSDPPKSPPECLGLELGLKGGDWVKAPPPADQVPKPFGDDLGFGIVYSSLTCHLCGHLKQHHSQEEGGQSPIVASPGCGCCYDDRSPSLGSLSGALESCPEGIPPEANLMSAPKTPSNLSGEGKGPGHSPVPSQTTEVPVGALGIAVS
The following text describes a protein:
Function:
Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
Sequence:
MERPPPRAAGRDPSALRAEAPWLRAEGPGPRAAPVTVPTPPQGSSVGGGFAGLEFARPQESEPRASDLGAPRTWTGAAAGPRTPSAHIPVPAQRATPGKARLDEVMAAAALTSLSTSPLLLGAPVAAFSPEPGLEPWKEALVRPPGSYSSSSNSGDWGWDLASDQSSPSTPSPPLPPEAAHFLFGEPTLRKRKSPAQVMFQCLWKSCGKVLSTASAMQRHIRLVHLGRQAEPEQSDGEEDFYYTELDVGVDTLTDGLSSLTPVSPTASMPPAFPRLELPELLEPPALPSPLRPPAPPLPPPPVLSTVANPQSCHSDRVYQGCLTPARLEPQPTEVGACPPALSSRIGVTLRKPRGDAKKCRKVYGMERRDLWCTACRWKKACQRFLD