lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MAVPGPAPGAGSRPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQLVIYQVGLIPSQYYGVLGNKDLEGFKALTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHCLYFRGRVYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIVSPFILVYYTYQCFQSTGWLGPVSIFGYFILGTMVNKTLMSPIVTKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRTDRRLQILLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWGLDKASGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVENELYRIGQQLGMTFISVGHRQSLEKFHSFVLKLCGGGRWELMRIKVE
The following text describes a protein:
Function:
Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular Localization:
Cytoplasmic vesicle. Secreted.
Sequence:
MVGNNVFLLLFMVCLSASGATATRELNSYSKAPGHNIAARLDEASLDSVNCWNVLHQLTPCGIEIVRFFINGRNGIIRDCCNAIQDMEQCEPGMFISLGFSYEEEKALISYCDASLGPAAAPLAGSPLSAEAYI
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MAKATTLGFYEVISFCLFFSFVAVVTQSAPESALVTQLPGFADTFLSKHYSGYVNIDQSHGKNLFYYFVESERKPSEDPVVLWLNGGPGCSSFDGFVYEHGPFNFEAAKTNGSLPQLHLNLYSWSKVSNIIYLDSPVGVGLSYSKNQSDYVTGDLQTATDTHAFLLKWFQLYSEFLSNPFFIAGESYAGVYVPTLSYEVVKGIDAGAKPVINFKGYLVGNGVADDEFDGNALVPFAHGMGLISDDLYEEVKNECRGNFYNPLSDTCESKLQKVDEDIRGLNMYDILEPCYHEPETPETADIKIRLPSSFRKLGETDRPLAVRKRMFGRAWPLRAPVRDGIVPTWPQLLDSQSVPCMDDEIATKWLNDAAVRKAIHAEEETVIGTWQLCTDNILYDHDAGSMIKYHKNLTSRGYRALIFSGDHDMCVPFTGSQAWTRSVGYKIVDEWRPWTSHGQVAGYLQGYENNLTFLTIKGAGHTVPEYKPREALDFYSRFLAGKAI
The following text describes a protein:
Function:
Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.
Subcellular Localization:
Nucleus.
Sequence:
MPRSFLVDSLVLREASDKKAPEGSPPPLFPYAVPPPHALHGLSPGACHARKAGLLCVCPLCVTASQLHGPPGPPALPLLKASFPPFGSQYCHAPLGRQHSVSPGVAHGPAAAAAAAALYQTSYPLPDPRQFHCISVDSSSNQLPSSKRMRTAFTSTQLLELEREFASNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGSNHRGGAGAGAGGGAPQGCKCSSLSSAKCSEDDDELPMSPSSSGKDDRDLTVTP
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Subcellular Localization:
Cytoplasm.
Sequence:
GPAGHGSRAGGALPGLVPGQRGGTRRGAWRPLPRSHCRPATRPERASHPAPLPGAGTGWPPMDSECYASMQVGMRVVRGADWKWGNQDNGEGNVGTVVEIGRQGSPTTPDRTVVVQWDQGTRTNYRTGFQGAYDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMNNKHDLAHSFERYETAHSRPVTVSARHNLPRITLRGIFQGAKVLRGPDWEWGNQDGGEGKPGRVIDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVVEAPGGFYYKDHLPRLGKPAELQRKASAESPPFQHGDKVKCLLAMDILREMQEGHGGWNPKMAEFIGQTGTVHRITDRGDVRVQFNSDARWTFHPGALTKHNTFWVGDMVRVIEDLETVKRLQAGHGEWTDDMALALGHIGKVMKVFGDGDLRVSIVGGQSWTFNPACLMAYHLEADANLNATESAKEPKSSLGAALEKLLTQKSDPEQPGRLVTEVAHGNVARVLELVKRHPDKVDVRNQGRTALQVASYLGQVELVRLLLQAHAGTDLRDDEGDAALHYAAFGNQAEVARVLVSRGACVNLINNAKCTALHVAVRKGFPEVACVLCEQGCDVNLPDMCGDTPLHCAISADTKGIIEILTEVPTIDFTASNCQGFNLLHHAALKGNTLAVRRILARARQLVDTKKDDGFTALHLAALNNHREVAETLIKEGRCDVNLRNNRHQLPLHLAVTQAHVALLPLLVGAGSDINAEDEAGDTAMHIALEKHQLLAPPIEAAGADEGAGLFSRLQASSFLGGAEPTVGIAMACFLAQEGADVSYANHWGKCPLDVVTDSRAAQAIRSFAQRRMGGLGRPRAASGWGWGAMGRPMGDLGALRMGGLGKPVGDLGALGRMGGLWGSPCDLSLGPADSSEVASSLSGLESAGQRQLMEELQSRYRQMEERITCPICIDSHIRLVFQCGHGSCLECSSALSVCPICRQAIRDRIQIFV
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MFAVISFLLVGSVTSAPRLQVKDEIAGKDIYYRNAVEDNKLWPSGVVPYVFNSEYASACKDEHQSCPHWASIGECDVNPNYMLVNCRLSCGVCEQISERSTCQDNHASCSYWASTGECQINPNYMLVNCQASCGTCQPTSTCQDNHELCYHWASIGECDVNPPYMLVNCMQSCNVCAIAEPTSDQKPEEGSEAAIILAAMADFHSETCIQFVPRTTEQDYIHIRKLGGCHSEVGRQGGRQELSLANDCLQKGTITHHLMRAIGFHYEHNRPDRDQWVEIQLDNVQDDHVHDFDKNPEGRTLNLPYDYGSVMHFGSHVFSKNGLETITAKQPLNGAVMGGWRHTGFSDLDIEKINTLYQC
The following text describes a protein:
Function:
Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MRLGVKVDIKKHYTEAEINRKRSTGKAFTLDVSFEMDNELVVLFGPSGSGKTTLFKCISGITQPDNGKITVGSKIYYDKDKKINLPIQKRNLGYVFQNYTLFPHMNVRKNIECGLKKWEKEDREVRVMEMLNLLHIEELETRYPSQISGGQKQRVALARALAPKPGILLLDEPFSALDMEIRTELADKIKNLQKKIEIPLLFITHNLEEAFLLADRILILHGGKIQQFGTPEEIFYQPANLQVSELIGISNIFDDAYVEEYDKESKSTVLRSGDMRIKIESPNFKAGDKVTWGIYPENITLLPVSGSEDQDENIYSAHVNNIINKGPKKRITLKLVRYNKTLIAEVPAQFVDSLELHAGGFCLVRLEMNKVVAFRNF
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MISQHFISGYCAVMLKAQVEFDDVFAEPEGTYSIDGVWKAAAKTFTQTKNVCYKALSLVCAIPLALVVGVSFACLSFQHIWCTGPAIRHCRINCHVVREYMRVILESCCAPCFSEMGLVLSRIRVQHVNGPDRRTETI
The following text describes a protein:
Function:
Plays an essential role in the switch from lysogenic to lytic state and in fine-tuning the lytic phase activation. Mediates the de-repression of the lytic promoters from repression by cI at an early stage of prophage induction. Turns down the expression of the transcriptional activator cII, a factor that initiates the expression of repressor cI, the major component promoting latency. Additionally, cro is able to directly bind to the promoter region of cI thereby preventing the transcription of cI repressor. These two mechanisms ultimately lead to a strong decrease in the amount of cI that will become unable to maintain the latent phase, allowing the transition to lytic growth. Low level of Cro also stimulates the lytic promoters while cI repressor is still present. Cro-mediated up-regulation of pR and pL ultimately leads to its own increased expression and to a successful switch to lytic growth. The second function assigned to Cro is the fine-tuning of the lytic phase activation. Indeed, cro initially diminishes the strength of activation by turning down the expression of lytic genes as well as its own expression.
Sequence:
MEQRITLKDYAMRFGQTKTAKDLGVYQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA
The following text describes a protein:
Function:
May negatively regulate brassinosteroid signaling.
Subcellular Localization:
Cell membrane.
Sequence:
MRRQPPRPRNSPPQSHSSPSSSSSEFEFNISISPRKASSSLCPADELFYKGQLLPLQLSPRLSLVRTLGSSTSSSDYTSSSSSSVATSAARDSTESNSSTDSTASFPLLHPPPLDCCDSSRPSSVTDDEDFFFKPPKNKSSSGGFSLSRFSSVFKKDPKTNLHHHSSSSSTATTAAAPSSVKRMSSTAKEVIRKYMKKVKPLYEKLSPKQSSNIKTESSSSLKDSGNNIRGTTTVTTVTAAPTVVSSGGGLSISFSGNLMKYTKRGRCAASCPSSMRSSPNHSGVLTRGGFPVHQGSCSSSSSNNNSVSSSMEELQSAIQGAIAHCKNSMLQKNLVSSLEI
The following text describes a protein:
Function:
Extracellular signaling peptide that may regulate primary root growth rate and systemic nitrogen (N)-demand signaling.
Subcellular Localization:
[C-terminally encoded peptide 14]: Secreted, extracellular space, apoplast. Note=Accumulates in xylem sap.
Sequence:
MAVRLIPTIWLFIVFAVIVSALPSLVSSRKLLEVKKQENLTVREEEKSHMPHVTKTSTLSALPKGKIPNSTPSKKGHAAVFAGKLRSRHLSTVDRYLRSVPSPGVGH
The following text describes a protein:
Function:
Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). Essential for viability.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNFLWKGRRFLIAGILPTFEGAADEIVDKENKTYKAFLASKPPEETGLERLKQMFTIDEFGSISSELNSVYQAGFLGFLIGAIYGGVTQSRVAYMNFMENNQATAFKSHFDAKKKLQDQFTVNFAKGGFKWGWRVGLFTTSYFGIITCMSVYRGKSSIYEYLAAGSITGSLYKVSLGLRGMAAGGIIGGFLGGVAGVTSLLLMKASGTSMEEVRYWQYKWRLDRDENIQQAFKKLTEDENPELFKAHDEKTSEHVSLDTIK
The following text describes a protein:
Function:
Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel-dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria.
Sequence:
MLDRIASIKKAPDEEYYVPGHRTCAGCGPALTYRLVAKAAGPNTIFIGPTGCMYVANTSYGCGPWRVPWIHAQITNGGAVASGIEAAYKAMIRKKKTDAEFPNIIVMAGDGGAVDIGLQALSAMLYRGHDVLFICYDNESYANTGIQTSPTTPYGANTTFTPPGEVVPEGKKLFPKDNPKVIAHGHPELKYVATASIGWPVDLMNKVRKGLNQEGPAYIHIHAPCPKGWQFPADKTIEMAKLAVQTGMFQLYEYENGEYKLSVKVDKRKPVSEYMKLQKRFAHLKPEHIAKMQAFVDARCAEVGITVPVVASNA
The following text describes a protein:
Function:
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
Subcellular Localization:
Secreted.
Sequence:
MQPRVFLVAVFLTLLVYANTQVTEETLLNRVQDYMQQAARQAQEALNNVQEYDVTKQAKDWVTDGISSLHDYWSTWTGKFSGLWEKAEEPVADVPPVDVA
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Subcellular Localization:
Nucleus speckle. Cytoplasm. Nucleus.
Sequence:
MFRIVNGEDYSPEVQQRNSLDFGKAPSLLWTDNGGSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKRPQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESRLSHSQPTNTTSSLLPQEHRSSWTSLSHNRVT
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MASKKQRIGVLTSGGDAPGLNAVIRAVVKSASGLGWEVIGIHDGFEGLLGTKSYRVLTNADVQGLLPRGGTILRTTNKGHFGPRRSDELSEADPYVRAVKAIEEMGLRALITIGGEGTQRIALELHKLGAPVIGVPKTIDNDLAGTDRTFGFDTALQVATDAIDRLHTTAASHNRVMVLEVMGRHTGWIALHAGLAGGADVILIPEIPFSIERVAEKVMARDQQGSSFSIIVVAEGARPRGGSEMYIAEGRLGGIGHWVGEQLEKLTAKEVRVVVLGHLQRGGSPSPYDRLLSTRYGAAAVQAAARGIYGEMVALRGQDIVTVPLAEACGHLNRVRPHSDLVLCARSLGIAFGDEL
The following text describes a protein:
Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sequence:
MGGVRGSPVASSKKKSSTLQYLFDLDSRANSGSNHSSPNNNGLQSPYDSEKEEILSAISICNTIFTFTDPSESPEQQDLKRFKLLQLLSITKSPKKQLDDYILSHLISMISANLFRPLPPPISTPITGDLPEDEELFSSPQPLWPHLQIVYDILLRLVLHVDPKTLRDYIDHRFLTNLLSLFQSEDLRERDSLKNIYHRIYAKFTFYRSFMRKAMNDVFLQYNFETEKHCGIGELLEIWGSIINGFTVPLKEEHKLFLIRVLIPLHKSKGMQAYHRQLAYCVSQFVQKEPALGGLVARGILKYWPVTNCRKEVLLIGELEELVDSIDPAQYRRLALPLCTKITKCLNSCNSEVAERALYVWNNEQFVRMVSSSLEDVFPVIVEGMEKNLKLHWSKSVKQLTENVKVMLEQMDPNLYSKCLEATEIRESAARQEEMKRKEKWRRIETLAAAKKQNQFLQPQQYIRVPH
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTAYVFLCPFAKVEESFNLQATHDLLVFGARSVEKFDHLEFPGVVPRTFLGSLAVASVNGPIHWVFMVLGAPKLWMQVATRWVLGMATLGALVFFSDGVGMRFGRDTSRFLLLICACQFHLVFYMSRTLPNVYALVLVLFGLGFWLRDKWQRSVFLFTFATVVFRGDTIVLFAPLVLSMLLSRRVSFFKMVWWGLSAGIVSLAATVLVDSYFWQRWLWPEGEVLWFNTVQNKSSDWGVSPPLWYFTSALPRALQATALLLPLGLSTLLPTLLKSRSLHDITWSFKTAPIVDWSVLSLVWPVFVYLALYSFLPHKELRFIFNAIPILNMVSAVARLPFVGAIGCLMITVLGTLFLLTAAWSNYPGGEAFVRLHHVAANERDLPRSVHIDVPAAMTGVSRFGEEFPAWSYSKDESVTTVDQLKQFNYVLTAKDPTLLEDDFQYVAGFDAFAGVGIANHRVTLKTKKIVFLMRNRDIIVPAQA
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE. Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4. The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide. Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol. Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation. Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional.
Miscellaneous:
MISCELLANEOUS: In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLQETISLTPLGQPLIAGFVVVSAVLYLLYNTQQWRPNNLPLLNDGGPFDFLQVTAVNRFRRDARRLIKSGFDSYKNVFAMRTDVGVELFASPEYADQFRNHPSLKVFPFTAKMHHGHLPGFELCRSQPVEDRILIESVRTQLAQSLGKLIQPLASDIGEAISDRWPSESGWQEIVLGSVVERTIAQGTSSVYCLDEAWPEFVVKMEMALGMASAALSAWPVMLRRIVAKFLPECLELYRIMKSGRELMSRDMRRRTALQASTGEEPLNFFEWFKEASHGEEYDELILNLRIAFASMHGLCDHLVKILLRLSEDPQLVSDLRKEVIQVYETHGWSKTALYHLKLMDSAFKEVQRVDPILFVGRVAVADVTLKDGLIIQKGQSIRISGHTMWDEDKYPDAAHFDPYRFYRLRQAPGQENTAQFTSPTSDHLGFGYGGRACPGRFFAAAVLKISLCHVLMKYDIKPANGETGQHVWEFAAAINANMTAKVLVRRRQPEIQI
The following text describes a protein:
Function:
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPLMLQPLDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEFQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL
The following text describes a protein:
Function:
Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with LSB5.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches.
Sequence:
MGINNPIPRSLKSETKKAAKVLRSFVKPNQVFGADQVIPPYVLKRAKGLAIITVLKAGFLFSGRAGSGVIVARLKDGTWSAPSAIAMAGAGAGGMVGVELTDFVFILNSEEAVRSFSEFGTITLGGNVSVSAGPLGRSAEAAASASTGGVSAVFAYSKSKGLFAGVSVEGSAILERREANRKFYGDNCTSKMILSGRVKVPPAADPLLRILESRAFNFTRHDHDDNASGDDFYDDGQYSDNTSHYYDDIPDSFDSTDESSTRPNTRSSRRRGMSLGSRSRYDDDYDDDGYGRGRGYGDFDSEDEDYDYGRSPNRNSSRNRGPQIDRGTKPRANTRWEDDLYDRDTEYSRPNHSGRDYDNTRGNRRGYGRERGYSLGHGPTHPSNMSNVDDLSHKMSKTGLGNESTATNSATPTAVALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGRTNGKEGIFPANYVRVS
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.
Subcellular Localization:
Nucleus.
Sequence:
MGVPAFFRWLTKKYPATVVNANEDRQRGVDGRRVPVDCTQPNPNFQEFDNLYLDMNGIIHPCTHPEDRPAPKNEDEMFALIFEYIDRIFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEMAEKAASIEEQRRRLIAEGIAVPQKKKDEEEAHFDSNCITPGTPFMARLADALRYYIHDRVTNDPAWANIEIILSDANVPGEGEHKIMDYIRKQRGNPAHDPNTVHCLCGADADLIMLGIATHEANFNIIREEFVPNQPRACELCGQYGHELKECRGAENDTDLGDEYCKPEQREKNFIFLRIPVLREYLEKEMAMPNLPFQFNLERALDDWVFLCFFVGNDFLPHLPSLEIREGAIDRLIKLYKEMVYEMKGYLTKDGIPELDRVEMIMRGLGKVEDEIFKRRQQDEERFKENQKNKKARMQQYGRGRGGRGRGRGQPAYVPSHGILAPMSAPMHHSGESTRQMASDARQAAMQFNATNDANAQAAANLKALLNVKGEQSPAEVAAQESRKRKAEQPIIITDEDEEPKDDIRLYESGWKERYYRAKFDVGSDDVDFRHRVAWAYVEGLCWVLRYYYQGCSSWDWYFPYHYAPFASDFETVGEFKPDFTRPTKPFNPLEQLMSVFPAASKQHLPVEWQKLMTEDESPIIDLYPADFRIDLNGKKYAWQGVALLPFVDEQRLLETLKSVYPTLTDEEKYRNTRGPNRIFIGRNHKSFAFFQQVAESKSNDLVDLDPSLLNGVSGKISYDSTATAPGLPFPSPVSHEECQDLPTNCGICVLYEDPEYPANYVFPAVRLDGAKEAEKTLRPEDWNERRDGRFNPTIGFNRNAPRGGLDLSGQRHINHHVRGAMYDRQGGNDNYRGGYRGGYQGGYDDRRGGRGGGGYRGGYNDSRPDFGRNYAGREGGGPQHYHEHQPGGGHGRPHDQQPYQDNRRGGGYHRGGRGNGPTGYQRPPYRGGRGRGGGGYQGNSSWR
The following text describes a protein:
Function:
The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNTWDDVWASDSDVETERSPDLLKLRENHSKRGYLDGIVSSKEEKLQEGFNDGFPTGAKLGKQVGIIMGILLGLRTRFGDEDEGLSKAYIDAQKELRINKVLSKSIFDPNFDLQEKHPLITKWTDIVNTYCEKYHVPSIQ
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MDTRGTSVFLLLCTIVVGLSSASHVHGDFRPCSAWRKYPITIKDVVINPEPVVSGDLVTFTVPAFTNLELQGGTVVVTVSLYGFKVHTEKDDICEKTACPVKGDFALSSSQELPPFTPPGLYKLKFQVLDNDGIEQACASVGFSIVWRPSMYALQEATRYAAQVVQD
The following text describes a protein:
Function:
Involved in the regulation of trehalose content by hydrolyzing trehalose to glucose.
Sequence:
MAPTAAVAGGGVEAEALLGLLQRVQSEALRAFGPNDFDPKLYVDLPLAADASAAAALASLPRAAPSRGEMEAYISRYFALAGSDLVAAADPPDFERDPPGFLPRVERAEARAWALEVHALWKDLTRRVAPAVAARPDRHTLLPLPGRVVVPGSRFREVYYWDSYWVVRGLLVSKMYETAKDIVLNLVYLVEKYGFVLNGARSYYTNRSQPPLLSSMVLDIYMATGDMAFVRRVFPSLLKEHSFWMSEVHNVAVMDNHGRVHNLSRYQAMWNKPRPESATIDEEFASKLSTAAKEKFYHQVASTAETGWDFSSRWMRDSTDMTTLTTSCIIPVDLNTFILKMEQDIAFFAKLIGESTTSEIFSEASKARHNAIDSVLWNADMEQWLDYWLPTDGNCQGVYQWKSISQNRAIFASNFVPLWLNAQHSGLEQFVDEAKSVRVMRSLQKSGLLQPAGIATSLSNTGQQWDFPNGWAPLQHLIVEGLLRSGSGEARELAEDIATRWVRTNYDAYKATGAMHEKYDVVTCGKSGGGGEYKPQTGFGWSNGVILSFLDEFGWPQDKKIDC
The following text describes a protein:
Function:
May be involved in endoplasmic reticulum exit trafficking of proteins.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium; MISCELLANEOUS: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSPQYHFYFVSFRNLVLNEKCLRSKKQVMKSFNWYKTDRYFDPHNILQHHSRAIEKTRYKLGMQTSSESTDAKSDFLDEPSAYLIEKNVALPKDIFGSYLSYWIYEVTRHKAAVILLVLIVTSILLLVFFYNTEFCVAFEILLFSFCFPGTCMVVIAFSEPIGDREFKVKLLMEIITRKPAVKGKEWRTITYKMNQYLFDHGLWDTPYYFYRDEDCHRYFLSLIKGRTFKKQKESSASNVKDAQSNDETAGTPNEAAESSSFSAGPNFIKLLTKAAEIEQQFQKEYWRQEYPGVDEFF
The following text describes a protein:
Function:
Overexpression has no effect on intracellular arabinose concentrations.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTAVSQTETRSSANFSLFRIAFAVFLTYMTVGLPLPVIPLFVHHELGYGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGGALLLAAILPVSAPFKFALLVVGRLILGFGESQLLTGALTWGLGIVGPKHSGKVMSWNGMAIYGALAVGAPLGLLIHSHYGFAALAITTMVLPVLAWACNGTVRKVPALAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVSLYFASKGWAMAGFTLTAFGGAFVVMRVMFGWMPDRFGGVKVAIVSLLVETVGLLLLWQAPGAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIALGVSGPLAGMLATTFGYSSVFLAGAISAVLGIIVTILSFRRG
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MEENNTAFRRSNSRLSMLDKSLERRRVNKEHNSNFRAGYVAVHEDHLHKTGLRGRKRFLAYFLLFLIYAVAIANLVLTVLIVLALRIDQNGSDVMEFRGEGGVKYKTDVMAERVLSDIGEFGGYKGQDLEVHGDGQPVILQHMIGHGSSVEFSGANTTLRSQEGLHIIDPLTGNTILHTANDSGIPSLTGMKQLKTTQVITTKVTPSIVDDLRVMSDQVLTIQGNEGLTIGAKDIDMSGSNIILNALDTLSLEGGPDGGIYINTTLLPRKSTASTGGVGMGLTLCVCGGTGRIFQVTAPPGVSHPCEKLITNPCL
The following text describes a protein:
Function:
Transcriptional activator of the fuc operon.
Sequence:
MNYRDELILQWVNQQGKASVIELAQHCDISVETIRRDLNKLANKGLLHRTHGGAVSNKTKDLGSFFQTRKHINATAKRHIAQKALDLLYENAVIGLDASSTSWYFAYLMPDIPCTVVTNSMFNINALVNKSNVKTIVTGGVYSAKYEAFYGPLSEYLLQRLHINFSVFSCSGIDKNGNIWESNELNASLKRKMMEASERAYLLIDSSKFEKTSLIQLADLSKINTIFSDRSLPDNLQKYCEQHDIMTVL
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters with high affinity. Can interact in vitro with linolenoyl-CoA. Binds palmitoyl-CoA and linoleoyl-CoA in vitro. Binds phosphatidic acid (PA) and phosphatidylcholine (PC) in vitro. May play a role in the biosynthesis of phospholipids.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGLQEEFEEFAEKAKTLPDTISNEDKLLLYGLYKQATVGPVTTGRPGIFNLKDRYKWDAWKAVEGKSKEEAMADYITKVKQLLEEASASTS