lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE2 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNH2/HERG alpha subunit Kv channel to form the rapidly activating component of the delayed rectifying potassium current (IKr) in heart. May associate with KCNQ2 and/or KCNQ3 alpha subunits to modulate the native M-type current (By similarity). May associate with HCN1 and HCN2 channel subunits to increase potassium current (By similarity). Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass membrane protein. Note=Colocalizes with KCNB1 at the plasma membrane. Localizes at the apical membrane of the choroid plexus epithelium.
Sequence:
MATLANLTQTLEDAFKKIFITYMDSWRRNTTAEEQALQARVDAENFYYVILYLMVMIGMFSFIVVAILVSTVKSKRREHSQHPYHQYIVEDWQEKYKSQILHLEDSKATIHENMGATGFTVSP
The following text describes a protein:
Function:
Has a calcium-dependent calmodulin-binding activity. Required for normal growth at various temperatures.
Miscellaneous:
MISCELLANEOUS: Present with 71700 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTPFGLDLGNNNSVLAVARNRGIDIVVNEVSNRSTPSVVGFGPKNRYLGETGKNKQTSNIKNTVANLKRIIGLDYHHPDFEQESKHFTSKLVELDDKKTGAEVRFAGEKHVFSATQLAAMFIDKVKDTVKQDTKANITDVCIAVPPWYTEEQRYNIADAARIAGLNPVRIVNDVTAAGVSYGIFKTDLPEGEEKPRIVAFVDIGHSSYTCSIMAFKKGQLKVLGTACDKHFGGRDFDLAITEHFADEFKTKYKIDIRENPKAYNRILTAAEKLKKVLSANTNAPFSVESVMNDVDVSSQLSREELEELVKPLLERVTEPVTKALAQAKLSAEEVDFVEIIGGTTRIPTLKQSISEAFGKPLSTTLNQDEAIAKGAAFICAIHSPTLRVRPFKFEDIHPYSVSYSWDKQVEDEDHMEVFPAGSSFPSTKLITLNRTGDFSMAASYTDITQLPPNTPEQIANWEITGVQLPEGQDSVPVKLKLRCDPSGLHTIEEAYTIEDIEVEEPIPLPEDAPEDAEQEFKKVTKTVKKDDLTIVAHTFGLDAKKLNELIEKENEMLAQDKLVAETEDRKNTLEEYIYTLRGKLEEEYAPFASDAEKTKLQGMLNKAEEWLYDEGFDSIKAKYIAKYEELASLGNIIRGRYLAKEEEKKQAIRSKQEASQMAAMAEKLAAQRKAEAEKKEEKKDTEGDVDMD
The following text describes a protein:
Function:
Regulator of biological processes that recruits a histone deacetylase to control gene transcription. May play a role in the entry into mitosis, negatively regulating the cell proliferation. Formation of stable complexes with geminiviridae replication-associated proteins may create a cellular environment which favors viral DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSSPRSPASPATVNNLGIKMSPTPVTAAMTTAKWLRNVISPLPSKPSQELEHFLFSCDRDFTNDVTHRANVILEAIFPSKSHVDRSISGTLQNVTQMDSLWAEDRKSEALKLYYRVLEAMCKAESLLLNATNLTPLLSHECFHRCMLACSAELVLATHKTVTIMFPDVLERTGITAFDLSKVIESYVRHEETLPRELKRHLNTFEEHLLESLAWEKGSSMYNSLIIARPSLSETINRLGLLADPMPSLDSITTIYNISNGRLSSSLPIKRDSLDATGEIQSPKRLCTERKLAERNSFTSPVKLKFPHLQSAFATPTRSNPAGGGETYAETGIHIFFTKILKLAANRIKSLCEKMQPPQPPKIRERVYFLIKQILSLQTFLFFNRHIDQLVLCSFYGVAKISHLTLTFKEIINSYKKQSQCRPQVFRSVYIDWSTMDRDGKTGQEHVDIITFYNEVFIPSVKPLLVELGSGSIVKNNRLPEEDASADGQCPGSPRLSPFPNLPDMSPKKVSASHNVYVSPLRSSKMDTLLSPSSTSYYAFVGESTHAYQSPSKDLTAINNRLNSHGNTRGKLKLNFDMVSDSLVAGSLCPQNGNSTLNPIVKSEKSHHQS
The following text describes a protein:
Function:
Binds calcium Ca(2+) and may act as a signal mediator to buffer Ca(2+).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MATIEVEQVTPVAAENIEVPPPKAVESEEVTTVSESLPAPVTESQAPVEVTTKDLVVEETEKPIEETEEAQVETPEVVEIKKDEEAPVETPVVVEDESKTEEVVEAKKEEEVEEKKTEEAPVVVEEEKKPEAEEEKPAVEASVTAPVEKADE
The following text describes a protein:
Function:
May be involved in the biogenesis of curli organelles.
Sequence:
MKRYLRWIVAAEFLFAAGNLHAVEVEVPGLLTDHTVSSIGHDFYRAFSDKWESDYTGNLTINERPSARWGSWITITVNQDVIFQTFLFPLKRDFEKTVVFALIQTEEALNRRQINQALLSTGDLAHDEF
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Subcellular Localization:
Mitochondrion.
Sequence:
MPPRSIEEWFYYKLLSSPGFHRFVRKVYRKVNGIKEDPFTDQSTAFQYLYKPTPRQKFKALRLLFWDEMRSTFGFRRRLGDRFKKD
The following text describes a protein:
Function:
Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
Subcellular Localization:
Nucleus.
Sequence:
MKFLESSEMDVFSQTLVTGAIDCVIDFKLETYSSKMVTSEKKQWKSNDKSVIWGERQPLGSYEEMVMSASPSVGHNHRLRHLSERSCSGGSDNDFDVNDYLIKDSISRKKLYDLTQVLNCSFPDHDFSNANSEAFALVNYSDLSRLVDMKLETIVRDYHVRREELWGIIDEAIVPGDCQIYSFKSQFEDDPFTEDGCIWALAFIFYNKGLKRFVLLTIRCLSKQADTSIEIFPDFSEDEAEPQEK
The following text describes a protein:
Function:
General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.
Subcellular Localization:
Nucleus.
Sequence:
MTGRVCRGCGGTDIELDAARGDAVCTACGSVLEDNIIVSEVQFVESSGGGSSAVGQFVSLDGAGKTPTLGGGFHVNLGKESRAQTLQNGRRHIHHLGNQLQLNQHCLDTAFNFFKMAVSRHLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFGEKNHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTLRKRLTEFEDTPTSQLTIDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISSYQDAIEIELENSRPKAKGGLASLAKDGSTEDTASSLCGEEDTEDEELEAAASHLNKDLYRELLGGAPGSSEAAGSPEWGGRPPALGSLLDPLPTAASLGISDSIRECISSQSSDPKDASGDGELDLSGIDDLEIDRYILNESEARVKAELWMRENAEYLREQREKEARIAKEKELGIYKEHKPKKSCKRREPIQASTAREAIEKMLEQKKISSKINYSVLRGLSSAGGGSPHREDAQPEHSASARKLSRRRTPASRSGADPVTSVGKRLRPLVSTQPAKKVATGEALLPSSPTLGAEPARPQAVLVESGPVSYHADEEADEEEPDEEDGEPCVSALQMMGSNDYGCDGDEDDGY
The following text describes a protein:
Function:
Intermediate baseplate protein. Involved in the tail assembly.
Subcellular Localization:
Virion. Note=Present in 12 copies in the baseplate.
Sequence:
MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVKVLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKWTPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIYRVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIMAMDQTEEINILFTF
The following text describes a protein:
Function:
Probable transcription factor.
Miscellaneous:
MISCELLANEOUS: Duplication of the STM3175 gene increases tolerance of albicidin.
Domain:
Binds the peptide antibiotic albicidin with sub-micromolar affinity.
Sequence:
MNDLISAAYSERLRRVCDHIERHLDEPLSIEALSRMAHSSPFHFHRQFTTWSGLPLYRYIQWLRLRRASWRLAFNPQDKVIDIALDAGFQNPESFTRAFKTAFGQSPRRFRQSPDWLAWHQRVPKLALQEQHVMDVKIVEFPPTRVAMLTHLGHPDKVNASAAKFIAWRRETGQSPIASSQTFGIAWHDPQTTPPAQFRFDICGSVRQPIAENDVGVVNSEIPGGRCAVVRHQGSLDSLPESVWYLFREWLPASGETPRDFPVFFQYLNFVHEVAEHELLTDIYLPLR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MELREEAWSPGPLDSEDQQMASHENPVDILIMDDDDVPSWPPTKLSPPQSAPPAGPPPRPRPPAPYICNECGKSFSHWSKLTRHQRTHTGERPNACADCGKTFSQSSHLVQHRRIHTGEKPYACLECGKRFSWSSNLMQHQRIHTGEKPYTCPDCGRSFTQSKSLAKHRRSHSGLKPFVCPRSGPGVAAKVLAASVRRAKGPEEAVAADGEIAIPVGDGEGIIVVGAPGEGAAAAAAMAGAGAKAAGPRSRRAPAPKPYVCLECGKGFGHGAGLLAHQRAQHGDGLGAAGGEEPAHICVECGEGFVQGAALRRHKKIHAVGAPSVCSSCGQSYYRAGGEEDDDDEAASGRCPECRAGEGR
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAQVLAHNKDFLRIQELNADGERERRSLYEDQLQAVEEEECLEGCAQTVVITAAEPTSAEKTREAAVGGRRQTPPPWYTSALMRKERLRFHQGSGEMQSLLRDVQFQCRGTIMDAFVNDPLRIYFSGPCFDSDKNRRLEAEVVEGPAVVRGVALGDGGQVTVQTVTTNFSGFYVLFWLSVAFALVKVTAGYYIKNDGNIMQSEIVHYMTTDLWRVAWFDLLMYLCTYFVFGVQWMCRRGWLRWAGAGWLLTSVYELLFFAYFTYVAEHTMRFKWISKIFLFLHSCVLVMKMHSYAFYNGYLWQILDELQFSRESLALLKDLDDEVDESVLRTLEKSEKFCQFELNSQSTSELFPSNITLRNYFMYSMFPTVVYQISYPRTDRIRWSYFMEKLAAIAGIIFIMMVVAQLLIYPVTIKAMSLRELGMSFSDRAKLWPNLLIEVVPGFIIMYLLVWYLIWDAILNCIAELTRFGDRYFYGDWWNCVNWGDFSRLWNVPVHKFLLRHVYHSSLSAFCLSTTQATFMTFILSSLIHELAMYVIFGKLRFYLFLFQMAQLPLMALNNSKLLHNKKVLLNVLFWLGICTGPSVICTIYLTF
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Presynaptic cell membrane. Note=Associates to membranes via lipid-binding activity.
Sequence:
MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQESQWNELLETLHRLPIPDPGVSVHLSVHSYFTVPDSRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFSEEAFVSHYRSGAMKQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDITENGCVSSAEDPLPKTMPSPQAETQDPRLREDRRPITVHFGQVRPPRPHVVRRPKSNITVEGRRTSVSSPEQPQPYRTLKESDSAEGDETESPEQLVREPWGPTPAPPDRAASIDLLEDVFSSLDVEAPLQPLGQAKSLEDLRAPKDLREQPGSFDYQRLDLCRSERGLSMAAALKLAHPYTKLWSLGQDDMAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAGGPLGDFSSEPLQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLALRPGESPLLPPRPPQSLQPTPQPSVPTQARDPFEDLLRKTKQDVSPSPAPALAPASTSVEQLRRQWETFE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEFVEYTRSNKYKMKRVVVVGSSNTDLIGYCERYPQPGETILGKEFHTGFGGKGANQCIMASKFNDVEVSMVGFLGHDQFGNSTLQNYKDNGVNTSQIHFCNLPTGVAMITVDKTAQNQIIVIPGANEALTPQFISTNANDIFKKGDIVVCQNEIPLETTYETLKQAKQHDCLTLWNPAPAPKEIDRNIIKYVDTLIVNTNESMQIGGESTPEESALKLHKEFGVLVIVTLGDKGCLIVGEEQTKIDSVRVNAIDTTGAGDAFVGSYARCWAIGLDPKRSAEISVRIASDSVTRHGTQSSYPNKEQIQKIISELN
The following text describes a protein:
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass membrane protein.
Sequence:
MTVPCRLPYFLQLYFICTVGLASPGGLETKEHRRSDYPEHVSAALPRKDTALEQYKSPPFDGNSQRQSPFNRQAHLPPDAGNRWDVPFNPAPDRESRKSHESLVLPFATVPKGELHAVRKSENNHAEMKLAPRQRPGSDVIEKRNDDDDGDGDGDGAQKPARMLDDRRPVRDDDVVDAAKDEYYDAPTREEHEGDNYEDGKIINSGTLDNIFAGKSNGPTSGTVIEHPKGSASVRGSKVGKALGGAAESNGAEEVDEDDEEEEEEEEEEEEEDENDSEVSYGEDVLPPSEAFGTFGERTGGGLKVEEAPYFLVEPQNTYVIRSKPAVLKCKAANTLQIHFKCSGSIKPPPSIEESHVDPHSGVHFQEVTATISRDLVYEYFGKLPFKCECHAWSPRGKAVSQPASIVVAYLKKNFDLMDTRIRAEAGEKLEIRCMAPKGYPKPQITWLKNNFTVTSSPLLTFTAEGNIVITSLNLQDIGNYTCVAENIAGKRISEPIELIVYVNGGWSQWSAWLECRCPGKPAQGRKRTRTCSDPIPLYGGAPCVGPNQQKTADCVTCPEDTQIITPNGFEDNAFVRRWSSWSAWSACSNKCTQSRRRTCRTQNIDYYDKALVKHHQQLAALMEDHDEQESTAYGCHGKDVQTIVCRGGECKIDDTASDWIFYLGLGFIVTLCLTFLVFLLHMRHRQKLPTYSITRTTPDQHTYTHEFQKKLTLSSNPPDINIRVNGYEYSNGSTMEAPKVPSQNVPLLLTRSTSEHHYDEPQFNSMQPNQALNKDGSAGVYNQQKLAGVILQHHYHQYHSLEQSHLQRQIASSPIAQSQKGQYRSSESLSGTSNTNTSISTYAIATTDSLDTSSSSEAMYKSNSVRQVVTSDGGWLEMEHLQTSLSIPEGAIPAALRINVFLAVMYDSKDTILVENQVTHISPTIVCGPAKSNFTKPLIIKVPHCAEDIGSWKVSLFYKEEVTNCWKKIASSENDVPSPQAYIQLDQHNAYIMTRKLGKYLLGGESLTPEVNVTKRLKIVMFGPARKPEADFNIRAYVLEDYPSALEHCSGIETRLGYFQIGQSSPFHFANNKEAMTLRINCSGGWTTAAECAVQKIPFNHIWKNMSILNCEFLLHKLTDEMPCLRLELAVEQDNGAKVLITSVAFS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Sequence:
MKSFFLYLYVAFMFSCITALPLPVDNKRASSDSLDLKKKYAPDPPITHNVNIGIVFTDPESSEEAGRLITIDLYGTMVPKTVMTFCQYVDSVKDRLASRHSYSPERDFDKILPNGAIEGSSVSSSSIEETEMLAPKLPEENHSLIHDRPGRVSMIKDDKGLKFIIETSETPLEGESVVFGQVTAGLKDLMDKLANVKTDENGKPEQPITIGYISSQEHRIQHAKEAHEKYLQRLQDYQNGDLEKGITLKNYLYQGSQRKLEDAKYNQLHHPLPKIMLGISVLLLFYVLAKYRKRIFNRSSKIVSIRED
The following text describes a protein:
Function:
Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases. Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons. May play a role in maintaining proper septate junction functions. Required for eye development and most likely affects corneal lens-formation.
Subcellular Localization:
Synapse. Note=Localizes to the submembranous region of synaptic terminals.
Sequence:
MEQKCIRRKGSVRLTEPTGHAHVRIEQRPQLPPRRQKSAEEVATMPKSALRQPPEQLEWFDRRAQQRHSARSAEGGQVREETMEWLKLQKTASPIQPVRTSSGPSEITVLKDELPDWLLDHLPRKKERERDRLPSDADKAVGSAYAKALADLLKKPLSRQGSGPCEFSLLKTDIVEWLTKMQSSSGTDRGKSRRSHHRRNGSGGDAQPRSNSQEDAQDQSKTSHRKRHSLGHSGAVSEEEQQQLTADWIAYPLHKLQSLGKQPPPAQPPERMSIPSGYAVPSALSHTPLCQRREERSRERRLRHSASEVVGSGGAGAASTSNTAHLERLYAKPHKERYQYVPKTKESSGRKERSRRHQTQRSATVSDMSAQRSGGHKRKSSSAERAPRSPSPGPCTDPDCPLLPICTDPHCRYQECQARQCITSSVSSVNLARHQQLAQVQLHAVPAHLVGAMGSDVPTTPSTTATPPPPTGGGTMGVGATGAGAGATSERRLVICHDCRSCAPLLSCRNRKCLNAAKCNSLPRCAADFNRLRTQLSQPPTTLDDIEPAPLDDLEMQPLPSPPHPHPHHHYRSNSQPNTLQRGDSASSAGMGAGVGGAGHGGLGGPGSGLAWLEPTTTLVQPLPAYVHHSNGKLMKSASAASLNSRRRRHKTVHFGENLLREVCQNRKLIKTEAQVPSGSAPMKANIQMLYNFVEGVLSAWVDDDEDQVRSGAESEPEHGVVPMQPIHRCNRLRYQCIRRVVEEAADLQGTLKLGNSRYRHRHWRSTAKQCNEMFLRKISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQVTGFCRSPQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGSPVWKPRDMINLGTDPQSTTRKDDVKN
The following text describes a protein:
Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase.
Subcellular Localization:
Mitochondrion.
Sequence:
MAESVASQTPSLSEQYHLEKEVKQDTSAKPVEVAPEVTSQAEDVSTDKASEESPAEEAVSAVEDKSESPPASEEAPPSVVVEDSADETPAAVEESNDDNASEEVVEETPDEIKLETAPADFRFPTTNQTRHCFTRYIEYHRCVAAKGDDAPECDKFSKFYRSLCPGEWVDKWNEQRENGTFPGPL
The following text describes a protein:
Function:
Catalyzes the transport of phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine) and phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine) between membranes. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus.
Sequence:
MENKNKKCLRTLLLLALFLGLLEDGKTALIAPNSQQIFKLQNQVILQELGRDSSSAETSYTFETDLKINSVWSGDEDQLLEVFISGSKVDASGKARSITRIPDRPFYISLVRGQPDKVIAHTSKDQSLLNLERGIASLLQLRLDASQEEELDVSGLCRVSYNVKSSTKVEKTKRDCSLWDLRVNYNPEEALGVTQQAQETVFYELSSEGTLLHAESQENHRLNLAAKPDVGSFVKSSLILQHVSQGSEEVKQLQLGSLDKAIQSLLEWYRVFELESDVDGMISAIKEQTLEDQLKASLTELQSADVGKSSLALAYVKLIPLARITRQEQFEDLLTEHAEVLPQLVDLLGAVQTFDAHNATFGFLYKESETTSEQLDLLEKYLQSLAVATHPDRKIVEHLFGLLEQESIKKHLKLRESVIQTVATLTRQSGLDVEDPLLKEVRSYLLQGLTSKEPTLYIRALQNLQDPATIEALLEHAQTGEAPNLSVAALQALKAFPLGSFNSSHRLQFESIFYQRKRRFDSSARTLALDIILSLRPTQEQLGNFLDYLASNDRQFEIKTYVLQKLRMLAEKCPRFRALFKSELVKRRHVNNYNVLGQKGLTTVLTRQLSQAPAFNETLLSTQEVYQGILKRGSVEFLLHAGRSQASSFKLGIYTAGLGSLVGDGDSGDGNDAIPADDEFSEDEAVTAGMEISVQGAQLRPLVFFSGQTELMGHVWGGSASDSTPAYQATTLSQDNEHYIILTSGATLHWRVLGARSVDLNGKVGFSLWNRNAQTEIQQNTGSAVLGHLAVGFTYAKLVQDFSITHEPKLSLNADLDFYSGIKLCMQLQRPEQLLKQTNVRSVFLQSVDRPYAKHVRSTLSHKTAGCTFALNQKNNEMCNLIFRDL
The following text describes a protein:
Function:
Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively.
Miscellaneous:
MISCELLANEOUS: Strictly specific for ribonucleosides.
Sequence:
MALPILLDCDPGHDDAIAIVLALASPELDVKAITSSAGNQTPEKTLRNVLRMLTLLNRTDIPVAGGAVKPLMRELIIADNVHGESGLDGPALPEPTFAPQNCTAVELMAKTLRESAEPVTIVSTGPQTNVALLLNSHPELHSKIARIVIMGGAMGLGNWTPAAEFNIYVDPEAAEIVFQSGIPVVMAGLDVTHKAQIHVEDTERFRAIGNPVSTIVAELLDFFLEYHKDEKWGFVGAPLHDPCTIAWLLKPELFTSVERWVGVETQGKYTQGMTVVDYYYLTGNKPNATVMVDVDRQGFVDLLADRLKFYA
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPAKGKYSLDKQELKQEALYRKFSGISQYRQFVLLLGLSIVTCATLLVLFFSFKLKAQNHGIFVGVVGGALCLFLAVFVLVCTETLSQRWRTLLGLGVWATHLTMGFTFIFSTKSDLQIQPWDQVPFFLFIIITVYTMLPFQMSYAVILSIISSLSHIIVLSVYLTVAQLHSNPITFQLLSNAVVFGCGIMVGIFHKVLMEKALKQTFQDTLRCLGIRMKLEIEKRQQENLLQSVLPVYISMKMKLAIMERCKCKDKEEQQRMVRDNNFHSLYVKRHENVSILYADIVGFTRLASDCSPKELVLMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPNHAKNCVKMGLDMCEAIKQVREATGVDINMRVGVHSGNVLCGVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLNKAYEVEEGNGHLRDTYLKELNIKTFLVIDPRSKDSSLMAPSITKPRVSDGLKMRASVRMTRFLESWGAVKPFAHLQSREEFNTDAMVNGKGHCKDIPLRSVPTHNPDSFDESLEEPFSLPAPPLSTYNRNKSQKTKFDEELHDKMTTTINDLSSSKQWVKSEEISGLTLWFTKKDLEMQYRTIEMPNFKYYIGCATFIFICIFIIQMLVTKQRIELGLGFAVLACFLLLILCICFADHIQRMFPEKLKSCTWLLALSKAVVKRPFVRILLATVATTVIVVIAMFELFLKKTDNLCDLLQQNSSFADSARDELQYLPYLVYNCILALIACGVFLRVSFELKLAFLLIVSLVSYTIILYSQENLFSNYNCLLYTNHSCGDSLMVCKAGLMKHPKIMSCIYITLFLFTMLLISRQNEYCCRQDFLLKNKNLADKEEVELCENLNRLLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYKDLYYKSYDCVCVMFASVPDFKEFYTECDINKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAAAGLSGPPEQSNQDRERQNAQIGNMVEFAIALIGKLDGINRHSFNTFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETSIVLQNLGYSCECRGLINVKGKGELKTFFVCTDSSKQQGIGLS
The following text describes a protein:
Function:
Probably required for the zinc-specific repression of the operon zuRMA implicated in zinc uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MGLTATEALMKMKEKGYKHTDKREFLINLLARKNKYLTAKDVLENMKDDFPGISFDTIYRNLSLFVELGIFEETDLSGERNFRLACTHEHHHHHFICMKCGKTKEIMMCPMDFLTEALPGYQIDGHKFEVYGECPECLQAS
The following text describes a protein:
Function:
Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis. Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. Involved in cilium biogenesis and controls cilium length. Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins. Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110. Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Mainly localizes at the centriolar wall, but also found in the pericentriolar material. Expressed in photoreceptor inner segment.
Sequence:
MIDSVKLRRDSAADFFSHYEYLCALQNSVPLPAVRACLREGVLDFNADRLRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKSEYQWITSPSVKEPSKTAKQKRRTIILGSGHKGKATIRIGLATKKPVSSGRKHSLGKEYYAPAPLPPGVSGFLPWRTAERAKRHRGFPLIKTRDICNQLQQPGFPVTVTVESPSSSEVEEVDDSSESVHEVPEKTSIEQEALQEKLEECLKQLKEERVIRLKVDKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLKDAGLGQLATMAGIDQSDFQLLGHPQMTSTVSNPPKEEKKALEDEKPEPKQNALGQMQNIQFQKITGDARIPLPLDSFPVPVSTPEGLGTSSNNLGVPATEQRQESFEGFIARMCSPSPDATSGTGSQRKEEELSRNSRSSSEKKTKTESH
The following text describes a protein:
Function:
Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport (Ref.5). In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host.
Subcellular Localization:
Periplasm. Secreted. Note=In some strains (e.g. non-MDR PAO1 and virulent clinical strain MDR25) forms long appendages distinct from flagella or pili on the cell surface: cell surface expression depends on type II secretion effector hxcR.
Sequence:
MKLKRLMAALTFVAAGVGAASAVAAIDPALPEYQKASGVSGNLSSVGSDTLANLMTMWAEEYKRLYPNVNIQIQAAGSSTAPPALTEGTANLGPMSRKMKDVELQAFEQKYGYKPTAVPVAVDALAIFVHKDNPIKGLTMQQVDAIFSATRLCGSKQDVKTWGDLGLTGDWAKKPVQLFGRNSVSGTYGYFKEEALCKGDFRPNVNEQPGSASVVQSVSQSLNGIGYSGIGYKTASVKTVALAKKEGAAFVEDNEQNALNGTYPLSRFLYVYVNKAPNKPLDPLEAQFLKLVLSKTGQQVVVKDGYIPLPAKVAEKAIKELGL
The following text describes a protein:
Function:
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MGGGREGAPGQEPAPGLSTNLLMKAQGTGKDCPHKKAATLLPSFTETPTTTGSTASPTTTHRPTTTSHRPTTTSHRPTTTSHRPTTTSHRPTTTSHRPTTTSHGNATVSPTTNSPGFSTVGPHPGPPPPSPSPSPSSTGALGNYTWTNGSQPCVQLQAQIQIRILYLTQGGKKAWGLSVLNPNKTKVQGGCDSAHPHLALSFPYGQLTFGFKQDRHQSHSTVYLNYMAVEYNVSFPQAAQWTFSAQNSSLQELQAPLGQSFCCGNTSIVLSPAIHLDLLSLRLQAAQLPDKGHFGPCFSCASDQSLLLPLIIGLVLLGLLTLVLIAFCVTRRRQSTYQPL
The following text describes a protein:
Function:
Has no antimicrobial activity. Strongly inhibits the formation of NO by neuronal nitric oxide synthase at micromolar concentrations.
Subcellular Localization:
Secreted.
Sequence:
GLLGSIGKVLGGYLAEKLKPK