lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MSSSVEKGSGSLDPGERPAAGSQPKACTACNTTKTPLWRGGPSGPMSLCNACGIRYRKKRREAMGLEDPPKKRQPAAAAAPAACSEAGGESADPEQQQPQQAKKTTTTTKRGREVELRVVGFGKEVVLKQRRRMRRRQRLGEEEKAAILLMAQQSSKHAGRDVAASLPAPPCSFLLVFPAD
The following text describes a protein:
Function:
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane. Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation.
Subcellular Localization:
Secreted. Golgi apparatus. Note=Both secreted and present in the Golgi apparatus.
Sequence:
MRRRRAAVAAGFCASFLLGSVLNVLFAPGSEPPRPGQSPGSSAAPGPGRRGGRGELARQIRERYEEVQRYSRGGPGPGAGRPERRRLMDLAPGGPGLQRPRPPRVRSPPDGAPGWPPAPGPGSPGPGPRLGCAALRNVSGAQYVGSGYTKAVYRVRLPGGAAVALKAVDFSGHDLGSCVREFGARRGCYRLAAHKLLKEMVLLERLRHPNVLQLYGYCYQDSEGIPDTLTTITELGAPVEMIQLLQTSWEDRFRICLSLGRLLHHLAHSPLGSVTLLDFRPRQFVLVNGELKVTDLDDARVEETPCTSSADCTLEFPARNFSLPCSAQGWCEGMNEKRNLYNAYRFFFTYLLPHSAPPSLRPLLDSIVNATGELAWGVDETLAQLETALHLFRSGQYLQNSTSSRAEYQRIPDSAITQEDYRCWPSYHHGGCLLSVFNLAEAIDVCESHAQCRAFVVTNQTTWTGRKLVFFKTGWNQVVPDAGKTTYVKAPG
The following text describes a protein:
Function:
Needed for flagellar regrowth and assembly.
Sequence:
MKELEVKKFTFYNFNDDISIEEDATKKNIKDEYTGKDLKVTSDILAKKEIVVEQDHYTKEKIEILKVESFNKGWSECEVAQKKLLDKVKKDNIYNILEKIDANLANINETIESRYENLANDCVELSYIIAEKLVGKLNKKFPNEAILEFLSNNLPLLSHASEIKIMVNPDNFIQIEDYLKNLHKDSMIKIKLIKDDSISINDCKIDWGNGVIKKDTKKVKEDLEEIFKNNL
The following text describes a protein:
Function:
NAD-dependent dehydrogenase involved in the biosynthesis of heptose moieties with a hydroxyl group at C6 found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the initial oxidation of C4 of the GDP-D-glycero-alpha-D-manno-heptose to form GDP-D-glycero-4-keto-alpha-D-lyxo-heptose in the presence of alpha-ketoglutarate required to recycle the NADH nucleotide.
Sequence:
MSKKVLITGGAGYIGSVLTPILLEKGYEVCVIDNLMFDQISLLSCFHNKNFTFINGDAMDENLIRQEVAKADIIIPLAALVGAPLCKRNPKLAKMINYEAVKMISDFASPSQIFIYPNTNSGYGIGEKDAMCTEESPLRPISEYGIDKVHAEQYLLDKGNCVTFRLATVFGISPRMRLDLLVNDFTYRAYRDKFIVLFEEHFRRNYIHVRDVVKGFIHGIENYDKMKGQAYNMGLSSANLTKRQLAETIKKYIPDFYIHSANIGEDPDKRDYLVSNTKLEATGWKPDNTLEDGIKELLRAFKMMKVNRFANFN
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH
The following text describes a protein:
Function:
Disease resistance (R) protein that specifically recognizes the AvrRps4 type III effector avirulence protein from P.syringae. Heterodimerization with RRS1B is required to form a functional complex to recognize AvrRps4 and to mediate the hypersensitive response.
Subcellular Localization:
Nucleus.
Domain:
The TIR domain is a signaling domain involved in cell death induction. It is involved in heterodimerization of RPS4B with RRS1B, but other domains also contribute to the interaction; The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MAASSSSTGLPPQHQVFINFRGEDLRLGFVSHLVEALENDNIKVFIDNYADKGEPLETLLTKIHDSKIALAIFSGKYTESTWCLRELAMIKDCVEKGKLVAIPIFYKVDPSTVRGVRGQFGDAFRDLEERDVIKKKEWKQALKWIPGLIGITVHDKSPESEILNEIVKEVKKVLKKVSLEGSQKVVSVDPSQSIDTLSSVGGEKDKTFGIKQRLKELEEKLDLVKYKGTRVIGVVGMPGIGKTTLVKELYKTWQGKFSRYALIDQIRGKSNNFRLECLPTLLLEKLLPELNNPQLDSIEEPYKTHKGLLRERKVLVVLDDVSRREQIYALLGKYDLHSKHEWIKDGSRIIIATNDISSLKGLVHDTYVVRQLNHRDGLQLFRYHAFHYDQATPPKVDFMKLSDEFVHYARGHPLALKILGRELYEKNMKHWETKLIILAQSPTTYIGEVVQVSYDELSLAQKDAFLDIACFRSQDVDYVESLLVSSDPGSAEAIKALKNKFLIDTCDGRVEMHDLLYRFSRELDLKASTQGGSKQRRLWVRQDIINVQQKTMGAANVRGIFLDLSEVKVETSLDREHFKNMRNLRYLKLYNSHCPHECLTNNKINMPDGLELPLKEVRCLHWLKFPLEELPNDFDPINLVDLKLPYSEIERLWDGVKDTPVLKWVDLNHSSKLCSLSGLSKAQNLQRLNLEGCTSLESLRDVNLTSLKTLTLSNCSNFKEFPLIPENLKALYLDGTSISQLPDNVGNLKRLVLLNMKDCKVLETIPTCVSELKTLQKLVLSGCSKLKEFPEINKSSLKILLLDGTSIKTMPQLPSVQYLCLSRNDHLIYLPAGINQVSQLTRLDLKYCTKLTYVPELPPTLQYLDAHGCSSLKNVAKPLARIMSTVQNHYTFNFTNCGNLEQAAKEEITSYAQRKCQLLSDARKHYNEGSEALFSTCFPGCEVPSWFGHEAVGSLLQRKLLPHWHDKRLSGIALCAVVSFPDSQDQLSCFSVTCTFKIKAEDKSWVPFTCPVGIWTREGNKKDRIESDHVFIAYISSPHSIRCLEEKNSDKCNFSEASLEFTVTSDTSGIGVFKVLKCGLSLVYENDKNKNSSLEAKYDVPVEVSFQEPEHGIMEEERYINKRRSDDRRPKKKRKTKRDDIMIISTVTQTCVPSVNARIEDKVTG
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MQIAPTARADPFCTHTHTLSHSLTHTRRHAIILAGGPDSRMNPFGGKPGRALLPVCNLPLISYTVGILERAKFDDVIVVAQKAAAPQILTQIKEVLGFKIQLHMHTIENNSDKGTADILRELKDVIKKDFMVLPCDLVTNVPIYQLADIHRKNNASATLLFASFPAKSPDDHVADRKRLQQHEDLKGLTDYVALDAESNRVLLFRSQADLSDSGTVDLRRRLLREHPQVVVRRDLLDAHLYIFDRWVLDFLVANEQISRIKGDLLPRLVRKQFSDKRTDDPSDVYNFLPPSPLAGLDLPGAESPSTRPPRITCFAHVVAAHGLDKAQPNDDAPLVARANTRTTYAELNHALQMTNKYFKMVCPLDGTMPETIHPEAELSGKDTKLGPECRVGAGSKLGKVTVKRSMIGRHCKIADCCKLTNCIVMDYVEIAENVTLTNCVVGNNARIGAFSSLTNCNVGPKYQVEEKVKSKDESFEDDAMAFF
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVGVIAGGISSEREVSLRSGQAVFNALKELGYDVVFIDAGIDLCEKIKIEKIDIAFLVLHGGWGENGAVQGMLEVMGIPYTGSGVLASALAMDKEASKKIFLYHGIPVPPFKVLNKKDYISSAVSLSSFSFPCVVKPAEEGSSIGVNIVKNEREFKNAINEAFQFGKRVIIEKFIEGREIHIGVLGDKALGGVEVRPKKGFYSYEAKYTKGLTEYILPPEIDNALYEKLKELGLKAHKSLNCKGGTRVDMIVDQQGNPYVLEVNTIPGMTETSLLPKIASLAGYDFKGLVKEILELSLKNNEK
The following text describes a protein:
Function:
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Postsynaptic density membrane.
Sequence:
MSTMRLLLLALLFSSSFARAGCDPKIVNIGAVLSTKKHEQIFREAVNQANKRHGTWKLQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPAPNDHLTPTPVSYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQANVWFEMMRVFNWNHVILIVSDDHEGRAAQKKLETLLEERESKSKKRNYENLDQLSYDNKRGPKAEKVLQFDPGTKNVTSLLLEAKELEARVIILSASEDDAATVYRSAAMLNMTGSGYVWLVGEREISGNALRYAPDGVIGLQLINGKNESAHISDAVAVVAQAVHDLFEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYSEGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGSNVLTNDRKIIWPGGETEKPQGYQMSTKLKIVTIHQEPFVYVKPTQADGTCREEFTINGDPVKKVFCTGPNETIPGRPTVALCCYGFCIDLLIRLAGVMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTAILAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDXPWKQNVSLAILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRSITSTLASSFKRRRSSKDTPCRMVPQECQRDRLAPWSQDSPGKLPPHSERPSAHHHPSCTASPRHIIPTAPGGDACVPHRQLLQLE
The following text describes a protein:
Function:
Positively regulates a late step in synaptic vesicle exocytosis.
Sequence:
MNPLTKALVTNKLSSVTKSIGLDDKDETTSEDAGVSSKEMRKMREKEEAERAKREEMYAKRNADREKKREQMRAKYGIQKDKDGPKKSGGHKEEGSDAPTRKGSLNREKSSEEDDNKCAIIGGLVTACIREIVTFSTSFPATRCLKRDIIRATLFDVGNYDCSLAKPGLYK
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRTVMAFDYGTKSIGSAIGQEITGTASPLKAFKANDGIPNWDEIEKQIKEWQPNLLIVGLPTDLHGKDLDTITPRAKKFAQRLHGRFGLPVELHDERLSTTEARAELFAMGGYKALSKGNVDCQSAVIILESWFESQWG
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MDISLDESCVALESSVKLLGKTLERLAEQGEHSRRLTSTLLRSKRVFELVSEYDLQRARLDVIEEVEPVVEKLCSKLEKSLNKLERERATLQQTYELNQLRLNNRLAGSGGRRPVVMGTSTTEELGRLREAKQRKAALEREIAEVRGT
The following text describes a protein:
Function:
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal, which allows E.coli to grow on putrescine as the sole nitrogen source. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.
Miscellaneous:
MISCELLANEOUS: 4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.
Sequence:
MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH
The following text describes a protein:
Function:
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Sequence:
MERMNWLSRLASRGPGHRVPQGANLQTPVMADPETCLMVFKNHWSQVVRILERQGPRAAGGVDDLSAVRNHTYQMLTLLVEDRAVPSAPTAPGPLLEFALREDLLTRVLAWQLQWDELGDGVEERRAEQLKLFEMLVSEARQPLLRHGPVREALLTLLDACGRPVPSSPALDEGLVLLLSQLCVCLAREPSLLEFFLQPPPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALLLLMALSAGSPTVGRYIADHSYFCPVLATGLSALYSSLPRKIEVPGDDWHCLRREDWLGVPALALFMSSLEFCNAVIQVGWVPRRSGPLVILGILRGKGAYSLEFYSAILGIGCLLCTFHSQTVATSHSSTLFLAPLQVAHPLVQKQLVDYIHNGFLVPVMGPALHKTSVEEMIASTAYLELFLRSISEPALLRTFLRFLLLHRHDTHTILDTLVARIGSNSRLCMVSLSLFRTLLNLSCEDVLLQLVLRYLVPCNHVMLSQKPAVRDVDLYGRAADKFLSLIPRCCRHRAPSPPRPEHASWARGGPSREAGRREDTTGPGSPSVDSSSVVTVPRPSTPSRLALFLRQQSLGGSESPVPAPRSPGLAASPASSPGRRPSPVEEPGELEDNYLEYLREARCGVDRCVRACRTWSAPYDGERPPPEPSPVGSRTKKRSLLPEEDRDNVGEGEEEELGSGGLAGGAGEGPSHLPPPQLNGVPGPWPEGAKKVRRVPQEGAGELLEGTSGGMAGLEGFGQELRELEVALSNGGAGSEPPLEPPLPLEEEEAYESFTCPPEPPGPFLSSPLRTLNQLPSQPFTGPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQPSVKSLLQVLGSVKNKIESFAASQEDFPALLSKAKKYLIARGKLDWAEGPTAGPAPRRSDPLVKSRRPSLGELLLRHAHSPTRARQAAQLVLQPGRDGAGLGLGGGSPGASTPVLPPRGGAPERQGEALRVKNAVYCAVIFPEFLKELAAISQAHAVTSPFLLDTSEEGSGPPVSGFGPLNP
The following text describes a protein:
Function:
Transcription factor that determines dorsal-ventral body axis.
Sequence:
MATANRNPVTELKEELTCPICLDHFSEPVSIECGHSFCRACITRTWRGIHSHFQCPQCRNISKWKFLRPNRLVGNMVEITGRLAATKMSPVSKKQCEKHQEPMKLFCQVDAKEICLVCRESVEHRTHTVIPVEESTSEFKVQLSNHLQTLRKEVATIIQTKSEDTEKAEKLQNEIKRKGRMLTSEFEILRQILADQESELKGRLENMERLIIQRTNERTSKLNEKLSSLQALIIDIEQNGHIYEEPKSVADRHSQNLQLCDPRQKPSRDSTMPARFFALKTFNVPVTLDHRTANPNLMLFGNRKKVRYEKYAMDLLNYPERFDMKPCVLGTTGYRSGKQYWEVEVGGGIYWSVGVAIQSVRRKGAFRIEPYVGIWAIGLLGVNADRYYAFTSYNTLLHPRDRPVVIGVFLNCEENRVSFFNAESFEHLYTFHDVRSPDKIFPFFCVGAMGTELRVVV
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKFNKVYTDTLVSVKEIMNKNKDNTLEFPDYTLKTKALEDLKLYSKDFSLKLNKQSKNNQSLIEENKIFSEQLVFYSSLFLNLNDESYNICDPLSNLFKLLSQLVQEIETCRNKFDQSISSKWLNQLQEFQKVDYKDSQLAKNRYDKARIQFDIASENFKNLRKKQNNNAERLLEAEDNLDFSTQQFSDIASESLNQMEEIIDKHNSESFESMCSSFSSYKEFFQKGLEICNSMEGELEKQKTNMNKYKQNLQEKKKLRSTVVQFEQSTNTVPAQQTPAAKGNTKVFGMNLSTITEREKSDIPSIIEKSLQFLSMEENITQEGIFRVSPNQRVLTELKNNVNAGFVTTLDGIDDAYLMSSFLKCFLREMPEPLFTFKLYQPLVNCVLEDEDECDKVKISEKIAGLIATLPRPNFILSKHLLSLLWKISTKSQKNKMTTSNLAVVIAPNILYPKVLDIRSLTNSNTTIEFMIANFTLIFNNPQILNLYNTNSSVSNTASSATASNPRHSTMVPPSLPARPQSVMFKQTPINVNVNNNNNPSGASPPHTPTKLSNSLPQLPHIPPKASNTTLSPQQAPALPPKNKRLSSSLQLPVQPQPQSSSSPSSPSSSPSPTPTGPNPLRSSTGSTQKPISNRVSMYLANSNSQNPPLPPKPNRNINTTLNNSNNSRLSSSAEISPPPLAPVELFETLEPSKKTPDNIKPETNWI
The following text describes a protein:
Function:
May function as the terminal enzyme of the myo-inositol oxidation (MIO) pathway. May also play a role in the salvage pathway for synthesis of nucleotide sugars.
Sequence:
MASGVHAAADGVAALGISPAGGEWAGPCPALRRNLHLLSHDQVELAKMLLNEGQGHLFEHWPEPGVDDDKKKSFFDQVCRLNSSYPGGLAAYIQNAKKLLAESKAGQNPYDGFAPSVPSGEVLTFGDDNFVSLEAAGVKEARNAAFVLVAGGLGERLGYKGIKVALPRETTTGKCFLQHYIESILALQEASCKMEGECHTKIPFAIMTSDDTNALTIKLLESNSYFGMEPSQVKILKQEKVACLADNDARLALDPNDKYKIQTKPHGHGDVHSLLYSSGLLEQWKNTGRRWVLFFQDTNGLLFNAIPSALGVSATKGYNVNSLAVPRKAKEAIGGITKLTHVDGRTMVINVEYNQLDPLLRATGHPDGDANCETGYSPYPGNINQLILELGPYIEELKKTHGAISEFVNPKYTDSTKTAFKSSTRLECMMQDYPKTLPPTAKVGFTVMDAWLAYAPVKNNPEDAAKVPKGNPFHSATSGEMAIYRANSLILRKAGAHISDPVASTFNGQEVEVWPRVAWSPRWGLTFKDVKQRLHGNSSVSQRSVLVINGRNVVIDGLSLDGALIVNSVDEAEVKVTGHVENKGWTIQHVDHRDTSEKEETRIRGFKFEKVEQLEVNYTEPGKHCLSP
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MPFVKIFLNLKLLKVVLVVLLFTSLLVPTLVIRNLSFAHKSSKDCLRLGKRAQFVINPPISNSPNARTCLSREFQQNLWKEVHTIPAPLSKALREYEKMHERCYLGRNLTQAILHPDPRDHCRYLVHAEADGLGNRLLTLATAFMYSLLTNRVFLVDRRGHLSKLLCEPFNHSWLLPEDFPYHLIDKAPKLGTINNSELGNIVRLFLVNAETGDQRFFCPETRSDLEDVPWIIWASNLYYVPRLFTFPEFWMRLTIWFPDVSLTFTQLSKYLLLPQNHVWHKITRLRSSYLSTPGKQLGMQVRLHHRGDPAVFHRPSLERILQCLTENKLLSSVVNADFAKNNSIRYEEPKKPIKVMVTSLQVKYYEELKNNFMNYPTADGRLIEVHTFSSDGVQTDSLEQAVNAMVEIWLLSTSDVFVSSSCSTFGYVAQALAGLRPYILNIQGDDLENCELTACSVGQSSDPCNHYPFFRDCEDLEKTKAHFEWEKIHIKGCQDEWEGIQLA
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MDSFGSRKYPKMHMSLVVHAQPAFGSLHTGVSTPSFSPNFFQNLQLEREMRLASNYTLARQNLAMQPRLENGKASLAIKYQELRELREACRDKQQRLGEPKLSCMAKWTPENALSRLQAELDGVEIRVEEQMERFLCWELPIESFVETFQHSRMLSHLRRTQLEKLQEMLKLEKEKTPGEKPSPGGEETPAISPAAPPMAPIPAVLPIPVAAGGPQKCCLPSLTASATHPSAAAPFGLIGHIHLPQAHLPHQTKKKEPPHR
The following text describes a protein:
Function:
Essential protein involved in the regulation of cell division planes during embryogenesis which defines cell patterning, especially longitudinal division planes of the proembryo, probably via the regulation of embryo patterning genes expression patterns.
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MAPHSLKKNYRCSRSLKQFYGGGPFIVSSDGSFIACACGDVINIVDSTDSSVKSTIEGESDTLTALALSPDDKLLFSAGHSRQIRVWDLETLKCIRSWKGHEGPVMGMACHASGGLLATAGADRKVLVWDVDGGFCTHYFRGHKGVVSSILFHPDSNKNILISGSDDATVRVWDLNAKNTEKKCLAIMEKHFSAVTSIALSEDGLTLFSAGRDKVVNLWDLHDYSCKATVATYEVLEAVTTVSSGTPFASFVASLDQKKSKKKESDSQATYFITVGERGVVRIWKSEGSICLYEQKSSDITVSSDDEESKRGFTAAAMLPSDHGLLCVTADQQFFFYSVVENVEETELVLSKRLVGYNEEIADMKFLGDEEQFLAVATNLEEVRVYDVATMSCSYVLAGHKEVVLSLDTCVSSSGNVLIVTGSKDKTVRLWNATSKSCIGVGTGHNGDILAVAFAKKSFSFFVSGSGDRTLKVWSLDGISEDSEEPINLKTRSVVAAHDKDINSVAVARNDSLVCTGSEDRTASIWRLPDLVHVVTLKGHKRRIFSVEFSTVDQCVMTASGDKTVKIWAISDGSCLKTFEGHTSSVLRASFITDGTQFVSCGADGLLKLWNVNTSECIATYDQHEDKVWALAVGKKTEMIATGGGDAVINLWHDSTASDKEDDFRKEEEAILRGQELENAVLDAEYTKAIRLAFELCRPHKVFELFSGLCRKRDSDEQIVKALQGLEKEEFRLLFEYVREWNTKPKLCHIAQFVLYKTFNILPPTEIVQVKGIGELLEGLIPYSQRHFSRIDRFVRSSFLLDYTLGEMSVIDPETVETEYPKDEKKKEKDVIAAMEQDTDELKQETPSRKRKSQKSKGKSNKKRLIAEAQGSVIAV
The following text describes a protein:
Function:
Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.
Subcellular Localization:
Nucleus speckle. Nucleus, nucleoplasm.
Sequence:
MFPPQEEADRTVFVGNLEARVREEILYELFLQAGPLTKVTICKDREGKPKTFGFVCFKHPESVSYAIALLNGIRLYGRPINVQYRFGSSRSSEPANQSFENCIKINSHSYRNEEVVGRASFPMQFFPINTAALPQGYFFFQKMQWPAYNPALQLPYYEMAASLPNSTAASSSLNCVPDLEAGPSSYERTHQQPSDPDLYQTNKRKRQKQTSDSDSSTENKRGNEYSQKFRKCKKKKRF
The following text describes a protein:
Function:
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSASSPAAWRGTLAGLIAFHIFIIIASNYLVQLPITLFGWHTTWGAFSFPFIFLATDLTVRLLGKGPARLVIARVMIPALIASYVVSVLFQEAAFRGFSALLEFNTFVARISLASFLAYVLGQILDIQVFDRLRRSRHWWTAPVASTILGNLLDTFTFFFVAFWRSDNPFMAQHWVEIATVDYGVKLSISLLLFVPLYGMLLNGILKMLPGRPQSNA
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Cytoplasm. Note=Localized at the cell tip and barrier septum.
Sequence:
MSADEEILAHYGLTSLSQDYWTEKPDFAIANASVDVQSPTTGVHHERNRSEDILRTGGATSETTKDASAAGPVTPSFAMKRSQTSVQPSMSSQIAIGGMRNPMATRKIAGTYRDAPDNSMQQTSTGVHRSSSWLTTDGTHQLLSLMETNFNKFIAAKETIDNVYAQIISTLSHAGPAKTMDMCEESISGALQQLQLFNTESTNEVDISYGELLVMRECEALFTYPEKFRLYHKQEKYSLLMQEIENAKKLYEKDRERLAKVNPKLVYLVDHAWEIIQATIDGICASIWNQILQSQGDFAFVVRTLCDLLKLKPNPISGRDPVLYATVSQQKYLYNLMKERFSYFEKIIKSRQEDFSKLSCTRASPMLVWRAVARGCNLDYTLRGRPEVFAGMQLIEWANACVLKIVREIKEVELYAKEFISGIQQASYPEAAKHYGRDPKQMGVVVEKLNSQCLEMVYSFVGERGERLEMDGAFVLIQLHYFQRVADLLPKRIRTVFSMAATRCIVDTWMLQHAPQSKSANIEEMFIVDANENQVLEPELMVVDVLRELNKLYIPPHREEIVREIHHAFYKVLYANARFPSMSVSMANWESDVWSLASSTLIDFVQHRNQHDMKKLASKMTTSLPVFSTSITRSDVLHFVTRLLNLRSRLVPYQKFLLQTFPLNEVSPSLDPRISKSLRNLQDLYKLLAIRDTSFSNTTPSSISKLSIQPPTFQLFSTLETIYLELKDSMPPNEAADWMIATTSCMLAQFALHSPYAFFHDIPSISHFLNKCLPPTILDLLQQIQRKAEASSISPTTETATKTRLKFQFIEMIFS
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRNLQCVHRGIIKPESVEAPDLNLVKTIYDPLSDAMVFVFDGLDTVEVQQFSKTEGTQVWANFPVSGHVLACDFLWESQTCVIFLSDGNVYSVEQGDQVINLGEMEGVESAAWSPDQQVVALGAKDKVLVLSRTFDPLSETPVSVDDLKLSRHVSVGWGSADTQFRGRGAKRDPTVPEHVDIGHVTESDESNITLCWRPDGEWLAQSSCDDVEGGKRRVVRVYSRDGQLFSVSEPVDGLLDLVAWGTSLIACVAKQEVVFFERNGLRHGGFHIGDFVPIGMQWNSTGEILALWSHETVRLYTTKNYRWYLKQEVVSRLPGNPKTLTWHPEKPRTIIINYDDHVEIHEYTDTVTSEPVNGVTCVIDGKLLLVTPLKLACVPPPMSRDEIHMEENIVAVSSSASHIAVLTREAVYIYDSLTVTHVTTHRLDLNNETVKAVVIHGEVPYVLAESASASRVITPAKSFPLHSDCIAFAKSHKAPLLQLLDGYVYLLQDTLEPLAKLPRCSTIAYTDEIYGLTSKGKLYKGDQVEASHVTSLLSSDDTLLYTTAERLYLAGESREIEKSSLLVSVHPSTYSVVLQAPRGNLETIHPRPLVLKRVSEALKNRDFKAALTICRTHRVDLNFLHDHDSELFMTHVSEFVDQVSSNHLDLFLTEVGVKNNPKGNEICDAVLTNTKNLLNQITAHSFKNPPDVAAALALVDSEESLEHLCFLHDVNHLYDTSLGLYDLEKTLLVAQQSQKDPKEYLPFLQKLQVMSEDRRKFTIDDHLEKYAKALESLIADKAEHEEIDTYITRHVLYNEALKLYTDKSDTQRVLNIYAAFLESTREYKEAGIIYESLEKWEEALEAYKAGVYWEEALCLCHAVEGFEDRVRDVADELAPQLVSAHCYKEASTLYADYLGDIMEAVRCLCLGSNFVAARALAARKAGGEKQRIFREIDSLLSDAFGTHSEFLADCQTQVKNQVSRLHEVRQLAQVSMSRELERLEDDNMVPDDISLADTASTSGTFLTKYTGKTAGTAKTGVSRRTAKNKRRMDRKKAKGKKGTVFEEEYLVASLGRLVERLEQSKVEIYNVIQALYSRDRRPLAHQLQQSLVALAASLTENVQFVFNRTMEDRKRIDDDGAVYYLDEVPVPEIKKVEVFASL
The following text describes a protein:
Function:
Acyl:acyl-carrier protein ligase involved in the biosynthesis of a unique class of isonitrile lipopeptides (INLPs) that seem to function as virulence factors in M.tuberculosis and to play a role in metal acquisition. Catalyzes the activation of medium/long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the phosphopantetheine arm of the acyl-carrier protein (ACP) Rv0100. Can use octanoate (C8), decanoate (C10), dodecanoate (C12), tetradecanoate (C14) and hexadecanoate (C16), but not hexanoate (C6) in vitro. Long chain saturated fatty acids are the preferred substrates. Acts twice during the INLP pathway, catalyzing the activation of a (2E)-enoyl fatty acid as well as the corresponding (3R)-3-isocyanyl-fatty acid as acyl-adenylates (acyl-AMP), and then the acyl transfer to the dedicated acyl-carrier protein Rv0100 (By similarity). Cannot use coenzyme A to form acyl-CoA.
Subcellular Localization:
Cytoplasm.
Domain:
Retains a single open conformational state for both the apo- and ligand-bound forms.
Sequence:
MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MSMLLYYFASAVKSIQFHVDDDIIDKLNYYYTTAIITVFAILVSAKQYVGFPIQCWVPATFTEPMEQYTENYCWVQNTYFLPLHDYIPHNYAERENRQIGYYQWVPFVLALEALLFYVPTIVWRLLSWQSEKRKLLFSREIETEKIRSFKENGAKKENASRTARRTTKISRKECAGPPVFQLLRFFFFSDILCRIHVQSLVQMACDSRLLDLESRNRALQTIATNVEEALHVKHQVMSGNRLKLLNLIICTRSSGAAVTFLYISVKILYTVNIVGQIFLLNTFLGNRSKWYGLQVLNDLMNGREWEESGHFPRVTLCDFEVKVLGNVHRHTVQCVLMINMFNEKIFLFLWFWYFLLAGATLCSLFYWIYISVVPSRQLNFVGKYLTGIEGYKMVDSQSLRRFVFHFLRQDGVFLLRMVATHAGELPCYELAKTLWNNYCDNKEGKMHDV