lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to the msc4 response regulator which is part of a multistep phosphorelay system that transmits oxidative stress signals to the spc1 MAPK cascade.
Sequence:
MSVYRDNMYMKYDRNFENRVARRNGQARNASLAKTLHDSGIAERARSPSGSAIPHAYRVMNGSGANDTSLPLTSNPAYVALTSRISSSKSENNQQLAANETAGAPEGTEETVDISNSISDDHANAKNLPAASVKALVGAGVLSDELSVIAYDMSFEDELIQDKQLIDHSVFDQLLEMDDDDEHEFSKSIVWNYFEQAETTIADLQKALEAKDLKKLSSLGHFLKGSSAVLGLTKMRKVCERIQNYGSLRSRDGVMKLPSEEIALDLISKSLSVVNDFYKDARAYLLDFYEKNSST
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Subcellular Localization:
Nucleus.
Sequence:
MSRDDSPLVRDVSPDEGYTYMHRAFFQAFLTHSVMTVEEIKPVLAHVMTAHNPERPWTAGDVTQPHLTSTIQTINARIEHYDFEIRSMKDQHTKLTVYALVNKTSDSLTQLATKFSASEIAYIRRLLDYMFETNNTHTREVMAIKHTEASQLARIRRARQSQVNGEEAESQAQDAGISIQEADEVLITLQNEGFFQKSPASYYSLAPRALMELRAYLKETYNEPASSPAADDAVIRIRDCEGCREIVTHGVRCNDKDCGVRWHDACANSYYRNRKGGNRKCPKCGTECSGDVYVGERADKVVARSSTGARRSAMHEEAEEEEEEE
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLGALYVVSGPSGAGKSTVCKLVRERLGINLSISATSRKPRNGEQEGVDYFFITAEEFERKIKNDDFLEYANVHGNYYGTLKSEVEERLKRGEKVLLEIDVQGGVQVKNKFPEANLIFFKTANKEELEKRLRGRNTDSEEVIQARLKNSLKELEYESKYDRVIINNEIEQACNDLISIIENGVK
The following text describes a protein:
Function:
Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal, such as 3-oxoacyl-CoA thiolase. Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol. Cargo protein-binding triggers interaction with PEX21 and formation of a ternary complex composed of PEX21 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MVVYVTLIVMLFGSTLVFYSLSPYYSALGLVVFSVPGSFVLSFLGSSFVPIVLFLVYIGGMLVVFPYSSAISPERFPSVNNLGEVVGLVFLFSSWVFMSFDNFQDLKNIFHCFVSGESLVGSNTFYNSGGVLVILGVFVLLVALVGALIISRGIESTIIRAIWLW
The following text describes a protein:
Function:
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MKFVKYFLILAVCCILLGAASIFGLYKYIEPQLPDVATLKDIRLQTPMQVYSAEGELIAQFGEKRRIPLTLNQIPPEMVHAFIATEDSRFYDHHGVDPVGILRAVSIAMLSGRASQGASTITQQLARNFFLSPERTLMRKIKEAFLAIRIEQMLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKEVHELTLSQIAMIAGLPKAPSTFNPLYSHDRAVARRNVVLLRMLDEKYITQAQYDQARSEELVANYHVPQIAFSAPYLAEMVRQEMIKRYGENAYTDGYQVYTTITRKLQLAAVDSLRANVLAYDMRHGYRGPSNVLWKVGESAWSREQIIDSLKALPVYGPLLPAVVTEADAAQATAMLADGSNVTLPMVGIRWARPFKSDNAQGPVPKKATDVVQPGQQIWVRKVDDNWWLAQVPDVNSALVSIDPNNGAIKALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGLTLATILNDLPITRWDSGAGTDWRPKNSPPTYDGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHSESLALGSASFTPLQLVRGYAVLANGGYLVDPYFITKITDDVGNVLFETKPKVVCDNCNLPVIYGDTQRSVVLSDDNIENVATSQNQNASNVPMPELEQVTPAQTTLNSEQQYAPHVISTPLAFLMRDALNSNIFGEPGWMGTGWRAGRDLKRKDIGGKTGTTNSSKDAWFSGYGPDTVTSVWIGFDDHRRNLGRSTASGAIPDQISGAEGGAKTAQPAWNDFMKVALEGLPEKQVPPPPGIVSVVIDKQTGKLSNGGPGSRSEYFIDGTQPTEHTVHEVGTTLMDNGQTHELF
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGFFKKNKRQSFNRNYEGEVQCNNIILGGTFYKHCENDLLLKNELENLVPYFNGRIFLENKEEIGKVDEILGPINEFYFSVKLKEGIRAKSFSSDTHFFIDKSQTLPLSRFLPQEKNSQSLVKKKKKKSNRDKKKNSFNQNNKKPNNYNFKGNNNRNDHNNRNDHNNRNDHNNRNDHNNRNDRNNRNNKNSFRNRSNSSRKFNNQRGRF
The following text describes a protein:
Function:
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
Subcellular Localization:
Secreted.
Sequence:
MALEKSLVRLLLLVLILLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSSSTYCNQMMRRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMHITDCRLTNGSRYPNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST
The following text describes a protein:
Function:
The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
Sequence:
MNIYVLMKRTFDTEEKIVIKNGAIYDGEAEFIINPYDEYAIEEAIQVRDAQGGEVTVVTVGGEDSEKELRTALAMGCDKAVLINIEDDVENGDQFTTAKVLAEYLKDKDADLILGGNVAIDGASGQVGPRVAEALNIPYVTTITKLEIDGTNVKIERDVEGDTEVIATSLPVLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLEEDDVEAKTKTIEIYLPPKKDAGKVLQGELQDQVKELVSLLHTEAKVI
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MSSQNAKSIGGILETSTVPLVIQPQIVNDPAQNNITLPITLCAVCGDTSNGNHYGVPTCFGCSGFFRRTVRNKLVHGCWNGDGNCVIDKANRNRCKSCRIKKCFKKGMNKNAVQPERTSHSYTVEYVELPSFREYSKGLLPTHSDRLRFQHEHAQHEIDTSSVLVHLKNALQWVQQFSLFAVLSDVEKSQIILTQWPHLLCLALFENSEKIFIDEKFAQLAEKFKSLELSAQDYFLLKGIIIFTETKDGTDLKFDRQLDICIGLLNQLHLESSKSKSGRLLFLLGELKSYSTRQLESLLDLKACEIVISFL
The following text describes a protein:
Function:
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Subcellular Localization:
Cell projection, cilium membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQAAWILKARALTEMVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPKLAKALFEYIFHHENDVKTIHLEDVVLHLGIYPFLLRNKNHIEKNALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML
The following text describes a protein:
Function:
Calcium-binding protein. Required for schizont to ring transition. Required for the breakdown of the parasitophorous vacuole membrane during egress. Required for the proteolytic maturation of apical membrane antigen 1 (AMA-1) during egress. Required for the proteolytic maturation of subtilisin-like protease 1 (SUB1) during egress. Required for the proteolytic maturation of plasmepsin X (PMX) during egress.
Miscellaneous:
MISCELLANEOUS: Possible target protein of synthetic antimalarial endoperoxides N-89 and N-251, which have high antimalarial potencies both in vivo and in vitro.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MMKINLYKLLCFICVIFLLHKNVVRSGDNMKYNDMKGLDDLSKLNDDQVKDILGLKIDGAKERIEKLFHLIDKNNDKEITEEELNTWSSFLKNEIFLKQVQAEMGQIDSDKDGFISLNELNDAFAQNLDAKEVEKHSEGLLKRFQIVDKDKDGKLSINEVGLLIDPMKDEELKELEINEILEHHDVNKDGKISLDEFKQTRSDESSGVKKDDEMALDDFNFFDANKDGFIDKEEIIKVYFDPAHESGAINVNEIKENIFEGKKITYDLWNEKALKIAVTSLTDYGDVIRYPEDFKLDIGKNVILPTARSRAFEDDDMDADNTEDDKDEADDASQQKSPAIDEL
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
Sequence:
MDLSAEFKRWKAQCLSKADLSRKGSVDEDVLEIVQLLNGQEQFFTTSSCAGRIILLDRSVNGSEVQKQNCCWLLVTHKACVKDDVIVALQKAKGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHQGKLMVTEEYINFLLKIANQKMEENKKRIERFYHCLQHALEKETVSTTSQPKEKVNTSYIRKKKRNPGKARGKRVNEEHDKELENNDHDDPGISDTIFPEDY
The following text describes a protein:
Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a role in spindle dynamics and genome integrity by targeting the mitotic progression protein PSRC1 for proteasomal degradation in a cell cycle-dependent manner. Also participates in meiosis by mediating the proper attachment between kinetochores and microtubules.
Sequence:
MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGNSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI
The following text describes a protein:
Function:
Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASTIASSATPQLRMSATKNRRKAPDLRNDEPSVRIPPPETSSIEDHFFWTYTEEPHRSRRQAIIKAHPEVTKLCGPEPLTKYVVLGVVSLQICCAYLLRETSFFSWRFWLTAYVIGATSNQNLFLAIHEISHNLAFRSPMANRLLAIFANLPIGLPYSAAFRPYHLTHHKSLGVAGLDTDLPTAFEAFVLDSLLGKAFFCTFQIFFYAVRPMFIYSPPFTIIHLINLFVQFSFNYILTKICNGSLNPLLYLLLSSFLAGSLHPCAGHFIAEHYFFSNVDHGTESLRELKGEKGEKHPLTSLPPPETYSYYGPLNILTYNVGLHNEHHDFPAIPWTKLHTLHRIASEFYEPLPCHRSWVWVIWTFILDENVGPWCRVKRAQGGRLVGGGDATGRAGEGISAGPDEANDDGWKESEIQN
The following text describes a protein:
Function:
When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
Sequence:
MTRKTIIVGVSGASCSGKSTLCQLLHAIFEGSSLVHEDDFYKTDAEIPVKNGIADWDCQESLNLDAFLENLHYIRDHGVLPTHLRNRENKNVAPEALIEYADIIKEFKAPAIPTLEQHLVFVDGFMMYVNEDLINAFDIRLMLVTDFDTLKRRREARTGYITLEGFWQDPPHYFENYVWPGYVHGHSHLFVNGDVTGKLLDKRIQLSPSSKMSVRDNVQWAINSILNALQ
The following text describes a protein:
Function:
Zinc-influx transporter. When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Expressed at the apical membranes of proximal tubules in the kidney.
Sequence:
MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMTELEPSKFSKQAAENEKKYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGRGHQDLDPDNEGELRHTRKREAPHVKNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLLSLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHSHGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEESTIGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIEEEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVLLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDMLPEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF
The following text describes a protein:
Function:
Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons (By similarity). Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity). Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (By similarity).
Subcellular Localization:
Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MKNNYTSLKSPLDEEDELKTDHEIDLEKGLLPEYNSEEEGALPPYSDISKLANPVPEDSSTGPTEIANPNVERRQEFKDSHPNIYFLLRLLISVLAVSVVFFTAWVCVNPLEKSIFGKVAFSVTIGITCPILFIAIFYFYETWTKACGKGIKHFLKKWRNMFFTFCKSPIFCLVLLKAENKLSSHLGDQQWGWKCSASAFTFMAVSSILIFIAETVEPGSCSTDLVKRVQAYCDYEARQYASSNTAIPLREMNPENEA
The following text describes a protein:
Function:
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVNELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENADEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQIPY
The following text describes a protein:
Function:
Sodium export from cell, takes up external protons in exchange for internal sodium ions.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAWSQVEISKPHLAYAIIGGFTSLFMLCSLIIKEKLFLGEATMATATGLIFGPYVAKLFVPTSWGNTDYITEELARVLLVVEVFAAGAELPRAYMLRHWRSMFVMLLPVMIFGWLVSTGFMYALIPRLSFLESLAIAACITATDPVLASSIVGKGKFARRVPGHLRNMLLAESGCNDGMAIPFLYLAIYLIIEKPARHAGRDWVCIIILYECTFGCVLGAIIGVIARKMIKFSERRGLMDRESFLVFYFVLALFCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDLLLNLSFFVYVGAIMPWPQFHMPHMDLSVWRLVVLAICILIARRIPAVLLFKSFVPDIINWREALFAGHFGPIGVGALYTCLVARAELEVHSTVPEPNDAIENPEIPNWYCIQVMWPVVCFLVLSSIIVHGSSIAFFMLGKRINTLALSFTRTRDSHFAFNLPRVRQGQSLPIKRVDALRSSANSIASSIRRRHPVNIQEDEDADISTVSLPEAAHLREERAESPRGGHYDAEEFPSEDYESRQPRRSNEEDREEEMNPGDETYLIGEDLVVEDSQGNIISHTSSRDANGPSIDEKLAQGDPKAKSFGRKFRSFLRRSYDTFQRNLHEPDDERQREPTLGHIESSIENHRPRYSRQNSESHLRENSVERRRREQVLTNIGDSESEDDNIPRPGIVPFYNENNESSSDTRNGLLSDNVSESRSRRPSRAPSAAVSSEGSPVEEDNEAQHRPNIRFLELTRAWE
The following text describes a protein:
Function:
Plays a positive role in the immune response to the oomycetes P.brassicae, including induced oxidative burst (e.g. H(2)O(2)) and enhanced expression of defense-related genes.
Subcellular Localization:
Plastid, chloroplast. Membrane; Multi-pass membrane protein.
Sequence:
MSWSLCSTHGVSSSIALTYGFRHRRRSTFRIFATSDGLEPKDDPPESPLPSSSSALGKDLKKVVNKTAATFAPRASTASKNPALPGTTLYKVFEVQGYASMFLGGVLSFNLLFPSSEPDLWRLMGMWSIWMFTIPSLRARDCPSKEKEALNYLFLIVPLLNVAIPFFWKSFALVWSADTVAFFAMYAWKLGWLERTE
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSVVVTEIYDDFILVIDAGDINHIKNAFRKVKGDKIRAVDGANEYLCEIEKIEDKEIKLKILEKIEDKFSLDIEVDAGISILKGDKMDLTIQKLTELGINKIIPISVKRCVVKLDKKKDRWDTISKEALKQCQGVVPTVIDEIKKINKLNFKDYDLILVPYENEKEIFIKEILRDLKIKPSKILYIIGAEGGFEKEEIDYLKENGAKIISLGKRILRAETAAIVTGGVIINEFL
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MAESSNRCNKSSGSGAGNAGKGAVSAEQVVAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLREVDPTRKCYRMVGGVLVERTVKEVLPALEGNKEQIQKIIETLTQQLQAKGRELNEFREKHNIRLMGEDEKPAAKDNGEGSGAKASSAGVLVS
The following text describes a protein:
Function:
Esterase that removed acetyl groups from a number of O-acetylated small substrates, such as acetylated xylose, short xylooligosaccharides and cephalosporin C. Has no activity towards polymeric acetylated xylan. Cannot cleave amide linkages.
Subcellular Localization:
Cytoplasm.
Sequence:
MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDLQPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEMVNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRALEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVALEQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPSTVFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG
The following text describes a protein:
Function:
Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan; Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (By similarity). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation.
Subcellular Localization:
Secreted. Note=Found in the apical region of pancreatic acinar cells.
Domain:
Lacks the EPN motif and the presence of Gln instead of Glu at amino-acid position 114 may explain its inability to bind peptidoglycan.
Sequence:
MLPHLVLNSISWMLLSCLLFVFQVQGEDFQKEVPSPRTSCPMGYKAYRSHCYALVMTPKSWFQADLVCQKRPSGHLVSILSGGEASFVSSLVNGRVDNYQDIWIGLHDPTMGQQPNGGGWEWSNSDVLNYLNWDGDPSSTVNRGHCGSLTASSGFLKWGDYYCDGTLPFVCKFKQ
The following text describes a protein:
Function:
Involved in the cell growth and proliferation. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. Spermidine cannot be used as an aminopropyl acceptor.
Subcellular Localization:
Cytoplasm.
Sequence:
MWITQEITPYLRKEYTIEAKLLDVRSEHNILEIFKSKDFGEIAMLNRQLLFKNFLHIESELLAHMGGCTKKELKEVLIVDGFDLELAHQLFKYDTHIDFVQADEKILDSFISFFPHFHEVKNNKNFTHAKQLLDLDIKKYDLIFCLQEPDIHRIDGLKRMLKEDGVFISVAKHPLLEHVSMQNALKNMGGVFSVAMPFVAPLRILSNKGYIYASFKTHPLKDLMTPKIEALTSVRYYNEDIHRAAFALPKNLQEVFKDNIKS
The following text describes a protein:
Function:
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity); Permits diffusion of specific solutes through the outer membrane.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKLLKSALLSAAFAGSVGSLQALPVGNPSDPSLLIDGTIWEGAAGDPCDPCATWCDAISLRAGFYGDYVFDRILKVDAPKTFSMGAKPTGSAAANYTTAVDRPNPAYNKHLHDAEWFTNAGFIALNIWDRFDVFCTLGASNGYIRGNSTAFNLVGLFGVKGTTVNANELPNVSLSNGVVELYTDTSFSWSVGARGALWECGCATLGAEFQYAQSKPKVEELNVICNVSQFSVNKPKGYKGVAFPLPTDAGVATATGTKSATINYHEWQVGASLSYRLNSLVPYIGVQWSRATFDADNIRIAQPKLPTAVLNLTAWNPSLLGNATALSTTDSFSDFMQIVSCQINKFKSRKACGVTVGATLVDADKWSLTAEARLINERAAHVSGQFRF
The following text describes a protein:
Function:
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity).
Subcellular Localization:
Mitochondrion matrix. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Sequence:
MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCRGPGYPDNRKMVINSGSVFRVRFFQTTAVCKNDVITVQTPAFAESVTEGDVRWEKAVGDAVAEDEVVCEIETDKTSVQVPSPANGIIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAETPAPAHKAEPAAPAAPPPPAAPVLTQMPPVPSPSQPPSSKPVSAIKPTAAPPLAEAGAAKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEVDMSNIQEMRARHKDAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDATKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYADIERTINELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHAIFDRPVAVGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL