lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the TREX-2 complex (transcription and export complex 2), a muliprotein complex that functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
Subcellular Localization:
Nucleus. Note=Apparent concentration to the nuclear periphery.
Sequence:
MAFRPFGKDLGPMSSKPAPFTPFGASSTTRLYLSFLFLHTANVGFACSDSSIQPPASQNHSAFAGQSFGPGGIRSGPSIQRAPPLSASQNPQLSIGKPYRPGGVQSVPPINRIPSPSAFQNPSPSSGQPYQPGGIQRIPEPFNGIAWGPEASRTSPSVRPYQFPGVQRPNLNPQYGHDGSRNFLKDHGEHSRATSPPATSHILSRMGTDAVEIGRSQDSKRKSRSDILPDQNMGFSRRNQSPVSGFENGNLVDGFQPLSSRTWMRSPSSAENNPVRSRSNPNQLIHQEQTGNSSFPYAHEVAEIQEATRRKSSAVAPSDKPLGDDPILSQHDSQRFSTSPPTSGTKSYTLSRSSDSQFPGQPSSVNSFNNARKTNSSPATKRTRSPPVYPIEEDIPRNSFPSQDCTEGEEQARAKRLARFKGELEPIADRPVDIQLTKSPVNKTMKPLDNKQTFNSLESSRDALKGDALPDYENSEQPSLIIGVCPDMCPESERGERERKGDLDHYERVDGDRNQTSKSLAVKKYTRTAEREAILIRPMPILQNTMEYLLSLLDRPYNENFLGMYNFLWDRMRAIRMDLRMQHIFNQEAITLLEQMIRLHIIAMHELCEYTKGEGFSEGFDAHLNIEQMNKTSVELFQMYDDHRKKGITVPTEKEFRGYYALLKLDKHPGYKVEPSELSLDLANMTPEIRQTSEVLFARNVARACRTGNFIAFFRLARKASYLQACLMHAHFSKLRTQALASLHSGLQINQGLPVSDMSNWIGMEEEDIEALLEYHGFSIKVFEEPYMVKNDLFLHADKDYKTKCSKLVHMKKSRTIVEDVSAPTVVEDVSTPFPLPSLITEATIGNQQCITAHKHEMPPARSLKKQTSMRLFDKEVADSKTSLLAEEDKPMGTFVMNPPGPFVINPVVHQEKQNDLTSAGGFHSPVKLYSPFGSPKFPQTKSSNLEKQPNDDRIGMSPGEIKFSIIGDVYTNHVPGPALQQSPKSMPMEIMPVTTIAECPTSVENKYALEESVPEAAMICTLEKEFNDIDEEDEDEDGVILNQYDEEVAKAKLKLIIRLWKRWSSRQSELRERRQLAAAAALNSLSLGTPIRFSKTDQSRACGEFNIDQAMRRRFEEREKSWSRLNISDVIADILVGRNPESKCISWKVVLCTQTKSVNSSSSASQVTHSAASRWLSSKLMPHAEHSSLNDDNLLFSAPGVSVWNKWVANGSDIDFTCCLSVARDVEAENDMCETTCGASAVLFLASGGLPLNLQREQLNLILESVPNGSVLPLLVVISSCNGEHMEPDTDIVSGLGLHDIDKSKIASFSIVSIANKSQKGQEVHFFNDSRLRDGFKWLASNSPLQPNLHHVKLRELFLTHFSFSLELLKQMPDQEVGPNICISAFNDALETSRRNITSAAEANPIGWPCPETMLLEDNRKECLMVKRYLPNLDWSSAENVELLSSVLENCKLPDFEDDLTWLTVGCASGAEIENHTQRLEGCLIEYLTQRSNLMGVSLATKETGVMLERNTRLELHNSSRYHITPRWIGIFQRIFNWRIMGLFDASSSSAYVLKSDLNMSTSSYADKFLAEDASYPSCPPNLPLLHEMIEISCSPLKSPPPYDDKAQRVVETGMLIDDHRDIEESMLEKNREACRGIDLMITEDDELGERSWRSKGREAAEKKTIEKRESERLDELLEKCNMVQNSIAEKLCIYF
The following text describes a protein:
Function:
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
Sequence:
MKVLMVASEVAPFARTGGLAEVTAALPAALRRMGHDVRVIMPFYRCAAQTELGVRKARKSAEVSLNGETHKGFLRQAALGDVPVYLVENREFFSRDYLYGTPEGDYPDNPRRFAFFCRSVLQFLKRMDFRPDVIHCHDWQTALIPIILRLEAADDPFFARTATVFTIHNLAYQGLFPAPAIAETGLPSALFTTEWLEYYGQLNLMKGAILTADLITTVSETYRREIMTPTQGCGLEGVLARRGDDLFGIVNGIDTDEWNPAADKRIFRNYSARALAGKAADKLELQRELGMPAAPSVPLIGMVSRLAEQKGIDLVLELLPRLAESELQFVLLGTGNACYLERLNSFRSKGAANISINLGFNDPLAPKIYAGSDLFLMPSRFEPCGLSQLIAMRYGTVPVVRHTGGLRDTVVDVTRHPREGTGFTFEDFTADACWEAIERALAGYRDRESWRRIMRRGMHRDVSWHNAAGRYETLYRMAADTRRG
The following text describes a protein:
Function:
Coreceptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal, such as 3-oxoacyl-CoA thiolase. Acts via its interaction with PEX7, promoting association between PEX7 bound to cargo proteins and the PEX13-PEX14 docking complex. PEX20 along with PEX7 and PTS2-containing cargo proteins are tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex. PEX20 coreceptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (By similarity). Also mediates peroxisomal import of proteins that do not contain PTS1- or PTS2-type peroxisomal targeting signals, such as acyl-CoA oxidases (Aox) izozymes. Import of acyl-CoA oxidases (Aox) izozymes is independent of PEX7.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix. Note=Cycles between the cytosol and the peroxisome matrix. Following binding to cargo proteins in the cytosol, recruited to the docking complex, composed of PEX13 and PEX14, leading to translocation into the peroxisome matrix along with cargo proteins. Export and recycling to the cytosol is initiated by binding to the PEX2-PEX10-PEX12 retrotranslocation channel. Cys-4 of PEX20 is then monoubiquitinated by PEX2, promoting its extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex (By similarity). Extraction is accompanied by release of bound cargo in the peroxisome matrix (By similarity).
Domain:
The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex.
Sequence:
MASCGPSNALQNLSKHASADRSLQHDRMAPGGAPGAQRQQFRSQTQGGQLNNEFQQFAQAGPAHNSFEQSQMGPHFGQQHFGQPHQPQMGQHAPMAHGQQSDWAQSFSQLNLGPQTGPQHTQQSNWGQDFMRQSPQSHQVQPQMANGVMGSMSGMSSFGPMYSNSQLMNSTYGLQTEHQQTHKTETKSSQDAAFEAAFGAVEESITKTSDKGKEVEKDPMEQTYRYDQADALNRQAEHISDNISREEVDIKTDENGEFASIARQIASSLEEADKSKFEKSTFMNLMRRIGNHEVTLDGDKLVNKEGEDIREEVRDELLREGASQENGFQSEAQQTAPLPVHHEAPPPEQIHPHTETGDKQLEDPMVYIEQEAARRAAESGRTVEEEKLNFYSPFEYAQKLGPQGVAKQSNWEEDYDF
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MLNLYMWKLSRSQVYQASLLFGSRVISALAFTNTGLVLHGPRRWYTTDNGFLLHRDSKVSLADYIHESTFDPSKGYYSRLWTGSTNNLSHSVHVLRKEGHKCSKEFDPFLHGIPIPQKALNIYEKQRSLFSESISNYLVLQYKLRYFPVFDLKIYDFHSGTGIIALDILDYLYKNHLEVYGRTTYNIVLHNSWQASWFKSMLTSVRYAKHGDHIDIYVSDPLTWNHTDTNPCFVLALQVISSFGHDLFRQSNGAMMMERCWLGPEHFLNEFFTLNTHQKVSSLNYHLAFQQARINVQQGFSDSRAKRYFSGVKQVFWSFFSTQKLTYYPTKAIRFFERLSKQFPHHSLLLMDVCHVDKSLPGINAPSVLSMENDFSTKKMSSNIGHVFQNETVKYVFPTPLYLVSDILQLATHNRSFICSLPHFLRRWSNEHGRKFFVPVEPSSKNLKVPYSFNNYYVVSSMPTYYY
The following text describes a protein:
Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization.
Subcellular Localization:
Nucleus.
Sequence:
MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPNAPPSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGDGLTAKASEKPPERKRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVSQRAGRSAVGTKMTCAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTFSKKPSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDPADATRCSICQKTGEVLHEVSNGSVVHRLCSDSCFSKFRANKGLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDFKRLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCHACKRQGKLLETIHWRGQIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSPESKPQTPSQTKVENSNTVRTPEENGNLGKIPVKTRSAPTAPTPPPPPPPATPRKNKAAMCKPLMQNRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQSAEGLLEDCDLFGPARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLVGPEDVSTEQDLPRTMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYANGETSKGDELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFSRVEEEHLWECKQLGVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKCTTPRGTTKVVSIRYYAPVRQRKGRDTGPGKRKREDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Subcellular Localization:
Cytoplasm.
Sequence:
MGQKAKAQAPTTHPRPHTLSSQVAPALPRRPRHAAPESLRQARGEVMKAHLITYGCQMNEYDTHLVQSQLVSFGADIVESPDEADFVLVNTCAVRGKPVDKVRSLLGDLRKQKAQRSLVVGMMGCLAQLEEGQQIARKFEVDVLLGPGSLLDIGAALESNERFWGLQFKDELHDHIPPPPSGKLQAHLTIMRGCDHHCTYCIVPTTRGPQVSRHPDDILRELDMQLAAGVREVTLLGQNVNAYGVDQGAKLKGYPSFADLLRMVGASGIERVKFTTSHPMNFTEDVAAAIGETPAICEFVHLPVQSGSDRVLRRMAREYNREKYLTHIAQIKKHIPDVVLATDIIVGFPGETEEDFQDTLSLYDEVGYDSAYMFIYSPRPGTPSYKHFQDLPRELKTERLQRLIARQKDWSARKNAQKVGTVQQVLLRGDAHDAGFLEGHTRGNHPTVVPKAIGADGAGVYQVRIDHATPHMMYGHILGPDGQPLPEQPRFNPEAAAVGGALPML
The following text describes a protein:
Function:
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation.
Subcellular Localization:
Nucleus.
Sequence:
MSGIGNKRAAGEPGTSMPPEKKTAVEDSGTTVETIKLGGVSSTEELDIRTLQSKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLDQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGDGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVDLLSRKLNSGDNLIVEEAVQELNSFLAQENVRLQELTDLLQEKHHTMSQEFCKLQGKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRHCELEKLRQDFEEVTTQNEKLKVELRSAVEEVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQRQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPTELKQDSEDLATHSSALKASQEDEVKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSVKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDLFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYIG
The following text describes a protein:
Function:
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).
Sequence:
MHDINFNILKDRAMDVDPDIRFMALEDLRKFLQDESAASTRTTLNQSLENFFPILLNMLNDQNPDVQTQAIKSFEPMVKYLSNETFSKLVKKLFALVQQNSSSTGNVTGMKSFTVSVPNIALRSLFAQSNSRDKSEFVSDKLSNSNYRFDPHLARYIMDYLIPQIVGNPVTIDSIELLIDLVTEIGYVLTQDELLNLSLYLTKVALTETGLIGKKSMVALERVVALVRTEVVIDKLLAQINQSIEPTKLFVIFQLYSVCLKRGIKPNSIDTIYNTITSNLNIEATEEEDDDDLDFDNLVKENSLKDEALTTLIDLVSQHFLPVESKNTVIALIKSYVNYNPLAQDEDFIDDEEDDISFSDDEQEDDGDGENDGSWKLRAKATILTRALLKSFPDTLELLSKEVLPVFSFADSNDQVVSEVIKSSIAIVNSTSPRDSTNVSELFPIIAARMKLAKETQVPLFLKLVESLNRFDNTSLVLEVFKIIKDRKLITSGSFDYLQFYSSTLKFHDNLPPLVIERMSSDFIKNLDDKSFNMITDSIKCLSLLFHQDSLEKLDAIVDLLIYKVENSKQYPSDLVRQSIIALGEAYGRADKQKILNVFKHSIEYEGTSKTTIDVLTQIYSTDIPSEYSYLILKKLSTSIMSSTEATSVASLLLMNKIFERLPSGDYDDTAGNLVQLLAVTNKANYECIFHILIKLVGTVLQETHRAPLLQTIVKLVNEGKIEVADNSFFQFITTACNQIPDLYNFFEDGLNLNSELSAKILAICASQNKLENKIMERREEFQNYYNSNINDSRLAFDILFLGYVGTHIEVKELDVQTLIGLLSNSQLTNDDNISAASTALGLIAQKHIDSAVPIILNAYESSEKTIIRGSLVDSLSIAADACNEDQKRVIWDKVFNFPVEFDHEVITELKKSGELLGKIPVVDELTINTDNLKTTYLILVITKSLLNNLQATKVNNTLLDSLIKSSIEWLNIVNIDIRQIVVGNLLTGLHSKPDTILPILDSIILPKIFDQLQAEDSFKKIITMGPYKYVLDEGLEIRKLCYEFIYSVISLENAVIKKYNINLEKIASKIIEVGLIDTQTDITVLACINLTNYIELHKDSAVELITRDGGNAFTTMINNLKKQLSKKLSAKASTQDSESHQERIKSIIKLSKKFASVVEAAESIELAAAIRVWNEYNNDLKTNFTIYYNSTDGV
The following text describes a protein:
Function:
Involved in the 3-hydroxypropionate cycle used for autotrophic carbon dioxide fixation, and in the glyoxylate assimilation cycle used to regenerate acetyl-CoA and produce pyruvate as universal precursor for biosynthesis. As a part of the 3-hydroxypropionate cycle, it catalyzes the cleavage of (S)-malyl-CoA to yield acetyl-CoA and glyoxylate. As part of the glyoxylate assimilation cycle, it catalyzes the condensation of glyoxylate with propionyl-CoA to yield (2R,3S)-beta-methylmalyl-CoA, and catalyzes the cleavage of (S)-citramalyl-CoA to yield acetyl-CoA and pyruvate (By similarity).
Sequence:
MRKLAHNFYKPLAIGAPEPIRELPVRPERVVHFFPPHVEKIRARIPEVAKQVDVLCGNLEDAIPMDAKEAARNGFIEVVKATDFGDTALWVRVNALNSPWVLDDIAEIVAAVGNKLDVIMIPKVEGPWDIHFVDQYLALLEARHQIKKPILIHALLETAQGMVNLEEIAGASPRMHGFSLGPADLAASRGMKTTRVGGGHPFYGVLADPQEGQAERPFYQQDLWHYTIARMVDVAVAHGLRAFYGPFGDIKDEAACEAQFRNAFLLGCTGAWSLAPNQIPIAKRVFSPDVNEVLFAKRILEAMPDGSGVAMIDGKMQDDATWKQAKVIVDLARMIAKKDPDLAQAYGL
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MAAASARQGERATSFAMACSLLSRYVRQNGAAAAELGLGINKGEAEAQRAADTKSPLPGAEGEEAGRKKETMELFPQSAGLHDAAAPDATREEDKSQLTIFYGGKVIVFNDFPADKAKGLMQLAGKGIPVVQNVSATTPVADSPKVQPAVLAPASSLPSDPVDAHKSARPNASDLPIARKASLHRFLEKRKDRLHAKAPYQASPSDATPVKKEFENQPWLGLGPNAALKPNQ
The following text describes a protein:
Function:
Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation; [Isoform 5]: More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Mainly localizes to the axon initial segment; [Isoform 5]: Cytoplasmic vesicle. Cell projection, podosome.
Domain:
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
Sequence:
MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP.
Sequence:
MSNPVSINNSGSISNSNLNNESLSPSRLSSSPNSKSMELNGKRTLKSSVVKTLLNRSSSGNNLNNTVTTRRAAGSFTSNYQNIYTPNNNSYNSSNNNNNNNNDDDTVSVDGDNPPDSPKSTKDHSNSVGSNSGGGGGGSSGGLNMSMNNIKQQQQDNLIKQQQKDRSLWTVRSLKEHAEVLDIMERLKPVNRAISFGQIYAREETQFDFDPLIGRDTMLQLILQHLQFEGLMDSRKLLEEEARVQYPEYAINESRLVTLLRTALKDSERVFQLTLDDKKRDSQQQLEEHLAFLGLFKDETATDIMGEDVNIYDEPENSNIIYVDDKEKEKEKEKEKEKEKDKFGPNSTNSLSGSGSSPNIPSGMNNNSSSIGNNSIGNSNSYSNGELSPLSASTLLMMSPQNKNSIETNKPQVKAASLNKLVILLTPDNNHDLEYTKTFLLTYQSFTTPEMLLEKLVQRYHVPQKPGQSLDDWKKSAVPIQLRVANVIRTWIKDYFSDFNDKLIQNVKSLYENMKQSGNMSHAKILSESLNAKIKGMVGMDDQKRAPTFTSPAPEPKVPKNIWSQTLDIFSVDEEEIARQLTLMDFEIFSAIKSTELLNQSWNKPKLRHRSPNVLTLINRFNEISQWTATSILSYPKVKDRARIMAKFIKIAEYCMRHLNNFNTSMAILSGLNASSVHRLKFTKEELPKHTQQVYTELQFHLSSAQAYKEYRALLAKANPPCLPYLGVYLTDLTFFEEGNPDFIQGFINFGKRKLIYGSISNVQSFQNAKYNLQPVYQITKLLKGFKLLEENDLYSRSMSFEPRNKERSEIL
The following text describes a protein:
Function:
Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology. Regulates mitochondrial morphology. These dynamic changes may be due to PA hydrolysis at the mitochondrial surface. May play a regulatory role in spermatogenesis or sperm function.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTSHIVFVVHGIGQKMDQGRIIKNTAMMREAARKMEEKHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMMGWNPGGLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEDRLHGLKAPSISQTPALKFKVENFFCMGSPLAVFLALRGIRPGNSGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPNFLNPAKEPTSVSDSENIAAIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSEPSKDSLEDDKKPSASPSTTTVATQTLPHSGSGFLDSAYFRLQESFFYLPQLLFPENVMQSKDDSLVELEHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDTEAKPSLGSL
The following text describes a protein:
Function:
Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Interacts with CBL; MISCELLANEOUS: [Isoform 2]: Interacts with CD2 cytoplasmic tail and does not interact with F-actin.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome. Cell junction, focal adhesion. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm.
Sequence:
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Subcellular Localization:
Nucleus.
Sequence:
MHKLKSSQKEKVRQFIAFTQTGEKTAIYCLSQNDWKLDIASDNYFQNPEAYYREHKPAVDRKKLEQLFNRYKDPHEEDKIGVEGVARFCDDLNLDPASRAVLAIAWKFKAATQCEFTKKEFLEGMTELGCDGMEKLKNKLPMVENELKEPSRFKDFYQFTFTFGKNPGQKGMDLEMAIAYWNIVLAGKFKFLDLWIRFLKEHHKRSIPKDTWNLLLDFSNMIADDMGNYDEEGAWPVLIDDFVEWAKPFVQGRSTTV
The following text describes a protein:
Function:
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
Subcellular Localization:
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Domain:
The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.
Sequence:
MKGLFLRIITALALLFWAIDMVFPWQFLRHTEENHYTAIQARGSLYVGTINNQISYFINKDSERGFEYELAKAFADTLGVELEMKIFDNQEQLFDELDKHNIDLAAAHLLYHPKNAERFQIGPAYHSASWQLAYRKNENRPKNLGNVKKDIYISNNLALEETLKELQKQYPQLIWKRNQALTQEELLLQLAEGKIPYVIANSIDIAAIQQIKPELAIAFDITDEANVHWYLPNNPYRDLQTALLNFMNNAEETGLLDNLKEKYLGHISQFDYVDTRSYMNAIENTLPQFSPLFEKYKGELDWRLLAAVAYQESHWNPDATSPTGVRGIMMLTKNTAQHMKISDRTDPEQSIKAGSEYLHWLISQLPESIEKEERIWFALVAYNIGLGHLIDARRLTQNLGGNPDNWFDVKKNLPLLAEKRYYSQLKYGYARGYEAHQYVENIRRYMNSIVNYHRVQENQTTNDNANNESAVKNLEEIKENKD
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDAPLVNESVEFQESQESLSLLEASKQLDLKKIQNLVDQGAVTSAIDIESGKNALHFIASYAEKETEVQAIEVTKWILSNGGVWNGIDRANETPGCIARRRNLLRLYETIVDAGVRSELLLSLLERKELTNEQLDTNEKYLQSALSYTQPTEDSSSLLDSDANAVMMSWERKIMHRSAEIIAPTKGRRVLNVGFGLGIIDTFLQEKEPSLHVIIEPHPDVLKHMRKNGWMDRENVIVYETTWENAINDIASKYVFDGIYYDAFAESYEDLRNFFDSVVGLLDPETDSKFSFFNGLGADNQTFYDVYKKLVPIDLVSFGLQCTYESMPVSSKDEEWKGAKRRYWDVSKYFLPIVTFDF