lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by satiety. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. Plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior.
Subcellular Localization:
Cytoplasmic vesicle membrane. Synapse. Note=Membrane-associated to vesicles (By similarity). Strongly enriched in synaptic fractions. Often concentrated at or near active zones of motor neuron synapses.
Domain:
The PH domain is essential for regulated exocytosis and binds phospholipids.
Sequence:
MLGASSSEEEDDDFQEDHDSLPIAQVKKRSLLSGAMTPRSSSPAPSDSVSQTNSLKRNNSSSQGRRKDSVQSQTPARSARIMSNVSKPIMQNSQEFDGDEEEGEEGSTTVVGSGDECGGPALSKEEQERMKAEREEEDHKKNLQMYMFLARCIAYPFNGQQTGDMARRQMKVNKQELARIRERFTLFLKGETNIAADEAFTKAIQSYFEVFLKSERVQKVVHAGGFSQHDFREVFRLNIEKRVRSLPDIEGLSKDTVLNSWLAKFDAIIKGDETDQNRNARGRSRNPQNAMSADAVLGKEQLYDVFQQILGVKKFEHQIIFNALQLDNPDEQAAAIRREFATREEALKDPIKMKRLTPKFVVKDMETLYMDEVRMSINTLIGNLETVPVTTRGATVGKRKDKSRSRSIEDLSLFNSLKRRTSSGSLNKGDSEDGDVTLTKSDVSLALSMEVVVMEVQGLKSVQPSKIVYCTMEVDGHKLQTDHAEASKPKWDTQGDFSTKNPLPVVKVKLYTEVKSMIAFEDKELGKVIIQPTPNCARSPEWYTMTLPKSSQDQNLKIRIAIRVEKPPNLKYCGYCYCIGRNAWKKWKKRFFCLVQVSQYAFAVCSFRQKKADPTEFIQLDGFTIDYMPESDPELSAQGGKHFFTAIKEGDELKFATDDENERHLWVQALYRATGQAYKPVPPKQSTIAPKAQGFQDKASKHGMDAMIQADSINFDHDHFYSDVQRLTLDFRINEPICSLGWFSPGQAFVLEEYSARYMVRGCFRHVTLLSNLLDKADDGLLIDPALIHYSFAFCASHVHGNRCMPDRQGPEGVGTVTLEEKEKFQEIKERLRVLLEKQITNFRYCFPFGRPEGALKGTLGLLERVLMKDVVSPVPPEEVRAVIRKCLEDAALVNYTRICNEAKIEQRMGIDVSPAQRIEDMIRVTEFCIDLLKENEEHHGEAFAWFSDLLSDHSEIFWSLYSVDLDSALEVQPHDSWDSFPLFQMLNDFLLSESSLKGGIFHNKIVQQFQPLVVRYIDLMEHSIAQAIDKGFSKEKWESRKEGCATSEDIYWKLDALHTFVIDLNWPEEDFRKYLQTKMKSLTSDMISKVSDCTFTAFDSWMQRAKKSTDYMLPSEVCVQINVMFSSKSRAVRVTVDSGEYKYQSKLDETLETMLKTMESCIQEKLHGVLESVLSRLARYDEGNPIGAILNIAPKPASIFNKLKTMAGDTSAQATTTARQPLTAQQSSGQIGNSYVTFFHGCTELLRQVIIDEIWVNGLFEHWYDNQMKSINEWLTERLQQSLSATQYISLSTIVKKVYQDFSLQGIDEERLNSKTYQSISRRLQLEESNSHIQEAAINGSAQGSVFPTSLGNATAAVSNMSSMVEGAGAKMFSLFK
The following text describes a protein:
Function:
DNA-binding protein that recognizes sites within both the enhancer and the promoter of rRNA transcription, as well as upstream of many genes transcribed by RNA polymerase II. It is essential for cell growth. May stimulate or inhibit transcription. Specifically recognizes the sequence 5'-CCGGGTA-3' or 5'-CGGGTRR-3' (where R is any purine). A member of the general regulatory factors (GRFs) which act as genome partitioners. Acts as a chromatin insulator which are known as STARs (Subtelomeric anti-silencing region). STARs prevent negative or positive transcription influence by extending across chromatin to a promoter.
Miscellaneous:
MISCELLANEOUS: Present with 7510 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPSGHNDKNANQESVEEAVLKYVGVGLDHQNHDPQLHTKDLENKHSKKQNIVESSSDVDVNNNDDSNRNEDNNDDSENISALNANESSSNVDHANSNEQHNAVMDWYLRQTAHNQQDDEDDENNNNTDNGNDSNNHFSQSDIVVDDDDDKNKKDAGVGVDDDHQSMAMAAVAAAYTLSKNNNNNNSIANDSNSRKRQHDNGNNHENSQKKRKNNNDDDDRQIGNVDPELTTLGDADDNDTNNDVIDRDQLVHKAIIDADSITQHPDFQQYLNTAADTDDNEKLKHIKDHLMRTHGLNHQNKNHNDDTDDLSNSTKQYSELQKDSMLDSSLNKSRNYMEVLPKVISQDTQPHQQKSPSHDNEAGSVDNSEISQLLQSAATKASSLVSLSSSSATPSTSRSNNSKAFDKAEDAALERFINEYEAIERLTRQQVCERIWSSDRPKDNFWNNIYKVLPYRSSSSIYKHMRRKYHIFEQRGKWTAEEEQELAKLCAEKEGQWAEIGKTLGRMPEDCRDRWRNYVKCGTNRASNRWSVEEEELLKKVISDMLEEAQQQQSQLHPNLLEEEQHLLQDDQNDHRNNDEDDDDTASAAAAAAAAIQEQQQLLQQKQQDDDDAIAAAAAAASSSLGDNKDEDKPHDSLGIQLDDNSQNSMVPAPSATSTHSKSLSNTIRRHNNKLRKSLMGNGKLDFKDIINWTIVSERMGGTRSRIQCRYKWNKLVKREAIAKIQTVKDDDMLWIFEKLRDLGITEDSQVDWDELAALKPGMKLNGLELKLCYERMKKKVKGYKQKSINEISKELVDYFSSNISMKTEN
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MLSTLLRLYQPKGLNRVELLRKMDLDAPNHLGIRSQQLGGRPIIKLIFDNVDQLQRVKKEVMDVLKKNEARRKDQGDEFQFSGSFATYDATYSHDNNNNDDTAAITAQKGDPLASLLDIREHDVPYLVRVCIDLSLRAGCWYTLTPLQSGGVSLSDPNNLQKANPTVLAFDIECTKAPLKFPDANVDSIFMISYMVNGQGYLLLSRHVVGKDVANFEYTPKPKYPGPFIVMNELTEEALIRRFLQEFQRHVPQIVVTYNGDFFDWPFLERRAAVYGLDLRKEIGFYNAAGSGGGGGGTMDNSSEYRGRTAVHLDAFCWVKRDSYLPQGSQGLKAVTKYKLGYDPVEVDPEDMVRYARDRPSHMASYSVSDAVATYYLYDKYVHMFIFSLCTIIPMGPEDVLRKGSGTLCEALLMVEACTKSIICPNKQVDPIAKFTEKGNLLESETYIGGKVECLETGVYRSDIEYKFDTKPEGFQSLIDNVDRDMTFAIEVEGGIDRRKITNYDEVRAEIVEKLELLRDRPSRMETPYVYHIDVGAMYPNIILTNRLQPSAIVDDATCASCDFNQIRNDCKRKMQWVWRGDYNPATKGEYDRTKDQLSRETGVNGEGQSFNDLDEREQAKAVSDRLKLYSKNAYKKTKVTEEITRTDTVCMRENDFYVDTVRQFRDRRYEYKKLTKVWGKKIGSATTPQQKRQAEDTALVYDSLQVAHKCILNSFYGYVMRKGARWRSMEMAGIVTKTGADLIVQARKLIEQIGRPLELDTDGIWCILPGSFPNIFTFKLDDGSTFRLEYPCIMLNADVHDNFTNHQYQTLKDPITKTYEAKSECSIFFELDGPYRCMVLPASTEEGKLLKKRYAVFNFDGSLAELKGFELKRRGELELIKTFQAQVFERFLDGSSLVDCYTSVAEIANHWIDILDTRGESLDTDELVDLISENRNMSRQLDDYGDQKGTSQTTARRLGEFLGAEIIKDKGLNCKFIISQLPHGAPVTDRAVPTAIWKAEPAVMKHYLRKWLKAPEMEGDDFDIRNVLDWDYYIERLNNTIRKIITIPAALQKVPNPVPRVPHPDWLQTTVRKMNDRYKQKYITSMFGGKKAIATDIESSQKGNAKVLDIEDFQSKSVGPGRPIVHSSRRQRKSPTSATAEGGIAEARIKLTKENLPAWLKKKKELWRNQRKERRKRAVASERDQLAPDASKKQKIALGSMEGYMRSAAEALTHHEWQVIEVRELASSDGSSSDGTFLLWVMVGNKSLQRIRIKLNRTVIVDSRVELQQGLIGALLVKRVEKHLPHNKSSGILYEVSMPEVVKTENLNQILESVYEMGTPLLLRALMHLGSVCRPSSGRDAKAGKVYDLSELSPVTREYLHSHLSYRRIFLYENLNQKKKSGLVGLFIMEGGSGDKADSQDGSILDLSRPQSSKNRSFLMNATCHFWVVKPGSGKNVQQSITKKQSLTGVDDVLKSYLQANNGPTMLMVNTSKPQPQFRKLVPSCNSFPFVPLAFPPGPAHNPSTSVLPSLNWEPTAVQLCLEAYLHMGVVSYPKRVSSARFAQVPIGNFSQDENTSMFDVLYARNLNKSRAVLWASDMPNNPDVGGFRHVETDLNNNDIWGDDDALVSPVILRPGAYRCVCVEIDVYDLSIAALTDSSLASLPGASLPTSNQTGALFDTETNIPNQVISSSNPLGDEMSTAISLPILRSLVNSWLRDAYQTNSQTADDLLHDVYRLISSPDALLNDPALHRVVHSLMKTIFLRLLGELQRLGSTIISADFHKVVIATNKSQIYDAKEYVEFVISTVLKRAGLARVSLRPNNFYTHYLFLDQNNFGGIHFEQREIEDDEENEMTQLFNSVVEEDGSSSIVPTVVCGWNIMQYLANDIAQDYFRTIIGRFSKDVFRKQLLIEHKEKSKISSISPISVTKSNDEDDENSSFLSPQEQLLNYKKKMISKHFANYLTRVVGELIDDGGGAESFPKLPGSYLHLSNPALEFVKNVLVVLNLDPDVKQEVIYLKKSLFAQIGVQEYSAVTQWKNPAAAFVLPDVYCMECHECRDVDLCVMPPDDDESTVKQWLCDGCASPYNVDQMERRLVDIVQKKCIRYQLQDLRCTKTQQVAVRSMSRTSDCSAALKLDIPRSEFLGQITILRNLADFYGLDWLLETVDGVLTGYA
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MFCREASSSLQTLSIANSLSSQFTKPSALINSLSAGHRYKLCPRPNLRGRCTVTASKFDINGKGKIVKDEVKKIKVKGTITVLSEEKKKKGTIMAQEGLLPSVGESLLVELISAETDPRTPMEKDPVEDYAQRDGHDDQYLQCVFDMPEDFGVVGAIRVVNLESKEIFLKEMKLEVPDGPVTFTFNSWVAPKSEDSTKRTFFSNKSYLPLKTPEPLKQLRKEELETLQGKNREGDSEFKKFERVYDYDVYNDVGNPDKDPELARPVLGGLSHPYPRRCKTGRKPCVIDPSTETRQKDFYVPRDEEFSKVKGDAFTGTAALAALPAALQQIEAFLLDPNMPFPHFKSIENLFEEGIEIPKDTGLFSLIPRIFKAIAAKAEDILLFESPILLDKDRFSWIRDNEFARQTLAGLNPYCIQLVREWPLKSKLDPAVYGDPNSLITSEIVEREIKGVMSFDEALENKRLFMLDYHDLLLPYVNKVRELDDSTLYASRTLFFLNDDSTLRPVAIELTRPQDKTRPQWRHVFTPGYDATSCWLWTLAKTHAISHDAGYHQLISHWLRTHCSMEPYIIAANRQLSAMHPIYRLLHPHFRYTMEINARARQSLVNAGGIIESCFWPGKYSLELSSDVYDKLWRFDREGLPADLISRGLAVEDETAEHGVRLTIPDYPFANDGLMLWDALKEWITDYVRSDEELKEWWNEVKNIGHGDKKNEPWWPDLKTQDDLIGVVTTIAWVASGHHAAVNFGQYGYGGYFPNRPTTSRKKMPVEEPTEDELKEFYEEPEKTMLKTFPSKKQATTVMFTLDLLSAHSPDEEYLGENPEASWVHEPVIYAAYERFKGKLQYLEGVIDERNLNVSLKNRAGSGVVKYELLKPISGPGVTGMGVPYSVSI
The following text describes a protein:
Function:
Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
Subcellular Localization:
Endoplasmic reticulum membrane. Microsome membrane.
Sequence:
MAGVMETDVVVIGAGISEHFHTHYLLSNVSKHNYSFSDFPFPDDVPDYPHHSHMAKYIADYVMHFGINEVISFQTQVNKIEKKDDKWVVTATRVEEDGKGGWTTGEEEVYVARFVAIATGHHVTPSLAKFPGQDTFKGELIHSADYKDPITNRLVGGRVLVVGIGNSAVDVAVDAATVGRCRKVLLSTRSGAWVLPNYIFGRPTDHYACRTFLLLPWKLATNVLETVVSLIHGSPYKWGLNPKMRALQTQPTVSPTLIHNIQRNNIAIKPNITRFEGSTVHFTDGSSEVVDHVVMCTGFRVSLPFLPDEVKEKVLEEGSNSIKLYKNVFSPAVGHSMAFIGFVQPASGGILSMSETQARWFAELCLNHVKLPSRAAMEAEIKADQEETSKRYFASARHTIQKDPLLYNDSIAAQFGAKPQLWRHPRLAWRLLLGSCGSAQWRLQGPGKWERAAEVVRSVPVTEFLLYSAILVVVLLLLLFTYLGYLISRMG
The following text describes a protein:
Function:
Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression.
Subcellular Localization:
Nucleus.
Sequence:
MVEVRHSIPCEETKRLELSLSQQTYSQQYASIYFARLTALRPRITEAASKKWPDKQRLERVLDVKSDEDCWVVATAYMTTALKPNVMNDVTQLHTIVTTTEESPYVSPEDAASGDIEYALEDDYGRIDCSGSFLYDAGVVTGVVLAVLGHEDEQGRFVVVDVCFPGIFSHSIPMTTDESQAQPEYIAAVSGLGLSNDGIEGIQVHQLVDFLRGTLPHVSSFSPSSIKRLIILGNCLAPSIEIADSASASVPIGKKKVKRYGYDTSAYNPNPTFQLDNFLDQVCSSIDVTLMPGPYDYSSTILPQQPLHPALLTKSKVWLGSSLQTVTNPTWLSLGNHFVLATSGQNINDLRKYHPKKSSLQCMENTLLWNHITPTSPDTLWCYPFTDKDTFVMEEMPDLYLCGNQPKFGCKTVINEGNRIQLVSVPEFRKTGVLVLINMHTLNVEIIQFRPMSVKAETPITS
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MILIMQKKNLWLHLLGLVILTLLSAYAVVKYPINLGLDLKGGVEFLLEPDFSVAIEREYEDLARNLREKLSKFNVLEVYATKEGVIIELLDKKEVENIKKVIQDINPNVIFEEEGDKLVVKFTQKYVEQLKEDIVRQSIEIIRDRIDKLGVTQPVVTRVGKYRILVDLPGFLDVERAKKIIGSTASLELKLVIDVSTDRKELEKKLTPDREILPSRDGREWFLVEKAPVITGQDLKTAYVGVDNLGQPAVNFELKGEAAEKFGKFTEQNIGKRLAIVLDRKVVSAPVIRSKISDRGQITGNFTAQEARDLALILRTGSLPSPLKFLQEKIVGPSLGKDAIEQGIKAGILAIILLAVVLIARYKTAGITANISIFLNVLFLLASMAFLGATLTLPGIAGIILNMGIAVDSNVLIFERVKEELRLGNTVSKAIELGFKRTLSAVWDTHVTLLVASVILFQFGSGPVKGFATTLALGTIASFISNVYYAKVFLDLLNSLKILKI
The following text describes a protein:
Function:
Catalyzes the O-acetylation of capsular polymeric sialic acid. Shows high substrate specificity toward polymers of sialic acid that contains a large number of residues.
Miscellaneous:
MISCELLANEOUS: Polymeric sialic acid-containing capsule provides a means for the bacteria to evade the immune response during infection by mimicking host sialic acid-containing cell surface structures. O-acetylation of the sialic acid residues of capsular polysaccharides alters their immunogenicity and susceptibility to glycosidases; MISCELLANEOUS: The catalytic efficiency increases linearly with the number of RLKTQDS repeats.
Sequence:
MLRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSRLKTQDSFSVDDNGSGNVFVCGDLVNSKENKVQFNGNNNKLIIEDDVECRWLTVIFRGDNNYVRIHKNSKIKGDIVATKGSKVIIGRRTTIGAGFEVVTDKCNVTIGHDCMIARDVILRASDGHPIFDIHSKKRINWAKDIIISSYVWVGRNVSIMKGVSVGSGSVIGYGSIVTKDVPSMCAAAGNPAKIIKRNIIWARTDKAELISDDKRCSSYHAKLTQ
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
SRMFGTNSTSNLYENMVEVCISSAMPQIRNLGSDQLNELLYSDEKLDAIISGLPQVRSLPSEKETDLAQNKSLAEWNLSQQPRLEQLKKQVKEKYDKVTELAQGLTSSQAEFAQISNGRSLEVTSNLMQVAMTEMDEEADELATQFKDKEIDYTAFSRPFLAKKNLVHKRKVKADRLSEMLQREDQPNRIESYTRPISMPSGVPNAAPYPDISRHSFW
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm, cytosol. Rough endoplasmic reticulum.
Sequence:
MGHQQLYWRHPRKFGQGSRSCHLCSNWHGLIQKYRLNMSGQCFCQYAKDIGFIKLD
The following text describes a protein:
Function:
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3'-5' exonuclease activity. The delta subunit is the wrench that will open the beta subunit dimer. The DNA clamp loading complex (tau(3),delta,delta') is thought to load beta dimers onto DNA by binding ATP which alters the complex's conformation so it can bind beta sliding clamp dimers and open them at one interface. Primed DNA is recognized, ATP is hydrolyzed releasing the clamp loading complex and closing the beta sliding clamp ring around the primed DNA.
Subcellular Localization:
Cytoplasm, nucleoid. Note=Localizes in tight foci to the chromosomal replication center at mid-cell; positioning does not rely on the C-terminus of SSB (ssbA).
Sequence:
MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQETKDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSALESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKRNEKNDPHY
The following text describes a protein:
Function:
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Sequence:
MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVKDTNKIDAFMEHVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKSAEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSNTPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLESDLLLARDGNHWWDDIQ
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MGITGLLPELKKSTEPINIEDMTGTVVAIDASCWLHSGLIGCAKEVFLGRPVDSYIRYFMGRIEILLRNGVTPLVVFDGRNPLPAKAELTAKRKQDRQKARTFARFALMEKNTTRFDRNCQDGLEVKPEMVDNVIKALKDRGVDYLMAPYEADPQLAFMSMSGAADYVITEDSDLLVYGAKKVIYKWDGHDGQLILHHHLYRSYPDFPQFTFEKFQHMCIISGCDYLGSIESIGLKRAATFVKSVGDGDIFKQIKNIGRITGRSNITVPPGYPEKLKMAVNTFTHQTVFHPDKGYVPLHDYPPGMSAVDMEYAGLPPSGAPIADLSRTWISEQMLNRTDQTDKTFEDPSSDTDSTTSNHYNLRSQQQAPVSTVFSIGEGLQWTPPCFPVMTLDFVTGTLSSEHNTPHSPCLFKASDHRVLLETPPFDITIQKSCTIKHESQSYIVVWEWDFFSLPDNYSDDIMSQFSQATISSGNTPEDAAYTTDQESDDSDSDSGDDDGEHEIAFKVMGVTKKLRRQEVLVIGRKMTQPPTVDIIPDPDNFYDANAIAVRLHTDKGPEIVGYIVTELTQYVHPLLNTDRLVCVRAGNITLRTEFLHPGYYMKLLITKKGKWEPAVVKASQWVK
The following text describes a protein:
Function:
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions. May play a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication.
Subcellular Localization:
Nucleus. Nucleus, PML body. Note=Mainly localizes in the nucleus. Colocalizes with PCNA on replication sites. Associates with chromatin. Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner.
Sequence:
MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTAHAAAGKRTESPGDRKQSIIDFFKPASKQGRHMLDSPQKSNIKYGGSRLSITGTERFERKLSSPKKSKTKRVPPEKSPIIEAFMKGVKEHHEDHGIHESCRPCVSLASKYLAKGTNIYVPSSYHLAKEMKSLKKNHRSPERRKSLFIHENNEKNDRDRGKTNADSKKQTTVAEADIFKNSSRSLSSRSSLSRHHPGESPLGAKFQLSLASYCRERELKRLRKEQMEQRINSENSFSEASNLSLKSSSIERKYKPRQEQRKQNDVIPGKNNLSNVENGHLSRKRSSSDSWEPTSAGSKQNKFPEKRKRNSVDSDLKSTRESMIPKARESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDISKEPNDETDCSSAGLAPSNSGSSGHHSTRNSDQIRVAGTKETKMQKPHLPLSQEKSAIKKASNLQKNKTTSSMTKEKETKLPLLSHVPSAGSSLVPLNAKNCALPVSKKDKERSSSKECSGHSTESTKHKEHKAKTNKADSNVSSGKISGGPLCSEYGAPTKSPPAALEVVPCVPSPAAPSDKAPSERESSGNSNAGSSALKRKLRGDFDSDEESLGYNLDSDEEEETLKSLEEIMALNFNQTPATTGKPPALSKELRSQSSDYTGHDHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIRQGRGIKSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDAIPDHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSVHTDCIVSVQILSTLMEITIRNDTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPDFNEDYLVSETQTTSRGKESEDSSYKPIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLINLMKNIRDWNTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHEDVPNASNLQVSVLHRYLVQMKPSDLLKKMVLKKKAEQPDGIIDDSLHLELEKQAYYLTYILLHLVGEVSCSHSFSSGQRKHFVLLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS
The following text describes a protein:
Function:
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the bicoumarin kotanin. The non-reducing polyketide synthase ktnS first catalyzes the formation of the pentaketidic 4,7-dihydroxy-5-methylcoumarin from acetyl coenzyme A and 4 malonyl coenzyme A molecules. Further O-methylation by ktnB leads to the formation of 7-demethylsiderin. Then, an oxidative phenol coupling catalyzed by the cytochrome P450 monooxygenase ktnC forms the 8,8'-dimer P-orlandin via dimerization the monomeric precursor, 7-demethylsiderin. P-orlandin is subsequently O-methylated in a stepwise fashion to demethylkotanin and kotanin.
Sequence:
MHKSAALSLRDAQFADMNMYCDVTDRTPIEAVHSCNNAESLNILNKLLARETDTALSQIFEQPTGKDWKELNTLQTILSLCSTVTMALLLGPDTAPDPVLHHHSTSFGEAIMSSCYRRTGYPRILRPFVWRFSSECRNLRKHFSLVRERLVPEVARRVAAARAADKTKDVRPSSLLDALIAAAFDNGSLSPDDQGRNDAAQVQLLADDLIFYHFELCKPTAFNIIFQLYAIMDHPEYKAPLREEALQALKLTNGDWTVETLKHAPKLESFTKETFRLYDISGFVSFRRVMKPLTLNSIGLSLRPGTILLSPCRNVHLDPEIYEDPTTFNGYRFYDSSREVCSPRVATTSLTFLTFSHGAGSCPARVLATQICRTIFIKFLLQYDVEPVQKEILPYGFTSGPVYMPNPSVMMRIRPRSDGK
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MRLSAIRQHGFGHLGVKVNKQIIYTMSAFEQNPIKGVLRKGVPNMIRRTRESFFVIAIPALLAYMAYDWGVTAQAKLDRKDPKMYENDV
The following text describes a protein:
Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGKSTKGKSKGKGKSESSSADSSMASKEVQPLASATGLPELVLKKAPSVPASIKQLPAEAPKQDVAEALAESSGVETSAAASEKTERSDESVEAEKKEKAESGETRDGNGAGDVDGDAELLLYPIIVKGPSGEKLELQVNPGDSVMDLRQFLLDAPETCFYTCYDLILNVADGARYHLAEYLEIGEVADISSGGCSLEMVNALYDDRMVRSHVRRTRDLISTSSIHSSLSTALAMEYEAKQAGEDKDAKDKSASKDKAAEPVKMELAELEGGLGFMEDSCGQLNLLISLPDPQENPCVQTIAFSSFNPVPGYRRLLGDLIYLDVVTAEGKSYCITAHTRGFYVNSSKGNILNPEKAASAFESTTLVGLLRQLSKKFVAGFAAILDKKSSGHPFENVPVLLPPNAWLGPHPIPPHKRDIARAEDALMVPYGTEVVGMQRDWNEELQSCREFSRDNLQDRIMRDRALYKVNCDFVEAATKGAKAVINRCIPPINPTDPDRFHMYVHNNIFFSFAVDGDFTLMQQVRDQNSQTGESSTEESTISNGDAKSDNAESNESDASLSLDANSGSAVVESEQATYASANNDLKGTKAYNNADVSGLYTLAMAIIDYRGHRVVAQSIIPGILQGDKTESLLYGSVDNGKKIAWNEKFHAKALEAGKLLHIKEHTVLDGAGKEVTLCAPVECKGIVGSDDRHYLLDLMRTTPRDINYTGPGCRLCVLRPELVAMFCQVEAQERATQRKADDDQADEKALVQEELSKIMLNPNVFTDFKVAGSQEEIEADEELVRKAGNYLKDTVLPRLVADLSSLEVSPMDGPTLTDALHAHGINIRYLGQVAKKAEHLPHIWDLAVVEMVVRAAKHVLKGVLRETLDQDVGGAIAHFFNCLVGSESANPVSEGKSVLSGKSLAKSVSGKSSSKESAQPETKPSYLCITPTLVWSDIEECVKFKYQFDLPSDAKSRIRKISTVRNLCQKVGVMLAARKYDFEVPAPFKTSDILDLQSVVKHLSPVCVDARDLLENGKQRLAQGKLNEAYEAFSEAFTILQQVCGPMHREVANCCRYLAMVLYHAGDMAGAIMQQHKELIINERCLGGDHPDTAHSYGNMALFYHGLNQTELALRHMARTLLLLNVSCGSDHPDVAATFINIAMMYQDIGKMEVALRYLQEALKRNKSLLGEEHIQTAVCYHALAIAFNCMGAYKLSLQHERSTYNILVKQLGEEDSRTKDSANWMKTFQIRDIQAHAQKQKGKEAISAAAAQKAAADALKARPDLVQAFQQAAASSTANRGSMGSSPPNLARARGAPDERAARAVNEVRKKAAARGLNVRPQATAPNQSIPPLGDLLSLINSGVAGKAPLATSSTPSSSTSKGTTKAAQAARPESSGRKSTSTPATAAPARPGPVSAVGNGPVQAALSAADLQAPSPVGLGSGLSLDAKKKKSKSKNAA
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MSLRKSSAQRRLGTPVSPFSPGKGFRPNNDKLEKEARRRSVARDLAEKQFLASPYRSPRVVSSKSSSKAPGNRSDENVPSDITDIYANCIKLCTENKVNQKNTWQLPLIDYMNDVMQTRHGEMTNFQIASCTLDASVKIYSYRIDSIHSEAYKVLGGIARGETRGDDDEEDADLEDGQGGEEGENAKKRRKKRATNTLEKNPQVLNVKKFDLAFDVDPLFKHMSAAFDEGGARGLLLNHLNTRDDGALLFDSHDTAQPEATDPVVAATEAAVDELLLASEEMLANLEGKAICPSLGGFNFVGWEPSDDLDTSNVSTSALVQAQARAGPAVADLSLNMDVEGGFGNLDSDDDVEFDQYEQQLGAYDEDGLAVSADSPQPHGGMARALKLSLDINNDYSYFSEEQLKNWAGPSHWRPRVAAGAIKGAKPKATKKKERFYIDFTEEEPNWKTAFAKGKASTMLSATTLKKKTEDELLLPEDKHFKLDFFQRLFGKPNTLVKPVAAASAACLADAAGGDNWYDYNNPNDMNNFCGAGVDGGDLVNAGLGGVADDDDDDDVDLGDFAPAGDAEPFAFGENTLLDDTMMPLNQTRMMGTNGLTLIDQPNKVGKIAIDYAKQAKRVNVKALKRSIWTQLTDGTETPTPLETPVATGAPLTDLSRHHALSELVSDVPQTLPSKTASNLSVPIMFVCLLHLANEKHLKLSTGDMMQDLHIAQA
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MELRKRGLRAPFIIFAAIVLFLLQFWAVTGQINHSELSTQIAVNSSSGTSTRFLSSSSPLSLTGKRSSFRFRWRRRRHHRNKVNRASIQFLYAHNLIRARVGEPPLRWDGRLAAYARRWARQRVGDCRLVHSNGPYGENIFWAGQNNWRTINIVKVWADENKFYDVKANTCEPGQMCGHYTQIVWRDSTKVGCARVDCSNGGLYAICVYNPPGNYEGENPFGNYEDQIGLVREDPPAVVVTPF