lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphatidylinositol 3-phosphate (PtdIns[3]P)-binding protein (By similarity). Involved in autophagy.
Sequence:
MEDQQEENMQQLLNLLPKDQRQIFEIFIQWLNGKSSGPIQLHQNALLTVLQASPYPALQLLQLLHERSKLHIGQIISTLLRQLLDGDVASPRSLCVLANFPASVLEASTLRQKLMTRLVVDSITSEHLMLTMLARSDGQLLDDLLHEQQLTMRAQCSEAAPTKLLVLWLALNEREHFVASVCQHLKDFKCFQDVTLRNNLLILRLANEFALGSQTLEELGCLEKLLAEFDVSAVPEKLQEVHGFFYADFQRLSTLLNFLRPREISKTLRVDALLRAPGVLPLIHENGIHFKHQELHRLIEDTYKWQQLTPALKCHHQEEVEILSYYTALCHVYDVVLDQGEQTTKTKLVQLSVQLRQLHQLGALCSLLEDIFLLVFLRWEQLEPNSQRKGEDGENDEEDDEQYVDDDVASPPRPTAVHSQRTRYGFICRSASLHALFTFLKAFVTKKIHSQDYKSAPEQQGRFQRLVDAISEALWKLGVLQKIEQSLLKSAPSISCLLEPDQLLQLVQLHSTAKKKASSDDESRERSNHASSLNRRKARRQRRAVSFSGGVAGKASADGGLAMEQLRARAQLLSGSGSRKNSSVTSPCERSIIPKMLSTPEQLAIMALALKNFNDVKKIIETFHLEHSQLNRELHFMEQQQLVKQKLSAIYANYQILEGQQANSGETTVEQIKGVAAKGFELSKIISVVDNFSQAHRLQQSPELKALIQRHNTSAQQGFLQQFEERNLNALIICDLIVNLGFNREITSNLLLVIRRQQQQKKGGDEASNTPGSSELGAMNLLQNLCECMRLLERSGQQAALNELLSLKSYPLRPAVLALQLQREAAFQTLYQKEPSEYSHGHELRSNANQFQQLRSRHNYYARFCTYVQQLARLLQLRDPNLEYHTTQLLRNDPYEVIGELIYECGITPLEIEASVAALHLNLVHVIALNICPQLSEEPTKRLPRVVAPQKQESIHNYISQHNQLLAHILLAIQLGSLPDGDADVDFSFLGHLVHLSEVNVLASVYDGNRVLAALNAYKLESARLDQLVTDQEQLLQILLLGMSGQTDSPNRHKSRIDQLIGDLIEKDPRNIHLVVHMGNLGQRAQLLKEHFTRIPSSQQAKELIERTLHHRSAAKSIPTALRSELEHTLSDITIYARVSALLKFESWPQAYDFGRQTPNVIFEQLLQRRRFGLCLEWSRVVYLAGSAGQQRVCLLTLLDALLELRDGEELDESLLGIVEMFPPNPLVNFLDTHKDKFRSLPLLQWVIDYLEGHARDPRLYRNYQLSLEFLRQMDTNERSPFWKLIRHPLLIVEQLVMNARFELLGKLLDAARSKLLKERPLGPCPYCFDKTGHVYDVQSSAGLGSGAGETPAKIRFQLGQTTSEAFILLNFNSYQQDHFVGQDCLDLLLRIYASKALDYHVANVRAASEPSSLGTDVHNSLDSLCGAFVMPKQAPNRQQWTRDEEASHCMCCRRAAFTMLMRRHHCRRCGRVVCYACSTHRIRIPELYDELEVRICNDCAACSTPAKDQGDGTSSERSAISGQVSKSSGRSDSCKWQLSGIITHDKLLREEFSYEHAPSVALSLSILRNHVEQRSCVDLLLFHCRKLEKLIVPNPEVDYGLVAKMINCLAFAAKVRGAPGELENIREHSEIIMAVVQQGCESLIPTGPLNNHNLRKLADALVEAEHWTLALEVHLKCGFATTGVMAAHGLACLRAGCYDAAREKFAHCMTRLSSEQLNSSICKNIFGVASTEAVLLPRKRPQRGPALLQEILQLIAAIPQVQTQPETLHRASLIRSSNTSLASLFTRRREPYVQPRPLQEPALNIMNALAGLKNLAKGQYGGQMPTSEESRRQERGFEESLHYVLTYGSHADILTFLMRREELRAALRYWQHQQLDADLFIHHIFYPQLANGGLNVLMDELQQLDDAQFTAWRLPLLQTCRHLEQQQQLSSLYQLQLLLKDPIRASMTCVKFYALQCENFQKLHANAQHLLSALRHLQGELDMAEWEHLQRQQARRNSVSSTASVRGACFAMQMDARALNGHINTIRRQLEVAKFLDKCEREQPPDEPLRTIQTLKQIRLESSRGTLPTLFEGAADRIQICILILMCGKNIDEGFGLAYGIMQDFKLAALKVFGATAKYLSRNQRLGEVERLLDCIGSNNGGDISTESDEILSIAINAAVHSSAPETKQMLDRLIKRIGSVELRVSSYIYIGQLKSAYLLANKHDRLADIRRILRQAELTGQVHIKKLCDMKLQLSAAPTPL
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MKAQKIAQIEVLDLEEEDEIFIKSTSQKGKRKRSAISVGQHIDDQRGPIKASQIFINLDDYFDDDDDLHVLNLLPHNTPLGKRKKPFSNHSVAENGQPSDSHKNDPSFVCEICVESKSPNESFRIKGCSHSYCTDCIIKYVASKLQESITTIGCPVTGCQGVLEPEYCRNILPQQVMFCAKCKVPWHTDMKCEDFQNLNENENDDIKLKKLAVEMKWKRCPNCGYYVEKFRGCNIIICRCGTSFHYYSRADLSELYPYRPASRQKGFRLKSRDPVRTLEYFDFLDLPEGKPP
The following text describes a protein:
Function:
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MHAFLGNPDRQLACAEFIQALEECHSRGYLARLVGVCNDQKAALGACLRQERLERTERNRNAAKERTAKKKAVWEALEREKAEETGKV
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MIHLSLYHEHYGVRYAPRGLASWLFYVLCLLAIVVAPFAIAFFMQNFWVKANYFYDMPEVTFTGRCAVRVSTVLGREYLWTCTDLFHGALQGTSLRILPYFSTYEDDRDGDGKIDYANFLMSFPLGDALEVSSLYEPTSAATGGGADAPTSQRDAILEASFLPEFVYYINHHLVKVNLTAAPLLRYRRTPMHKGFGNVTTATSSTYSWSGTPVCALTKADMLFYTTHSLINSPYVSYMHTYTSSPLQELARQPADLLDLPRFSGNYAARNQSVVLRPYVEAAGGLDVLRRDVSIVRGLWEDLDDLNTFTWYVQLRIPPAEVQYVPSYAEVLKWGWIQYFAIAYIVQWLLWKLRMVLVTMGLINSRARFSTMRRQY
The following text describes a protein:
Function:
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body (By similarity).
Sequence:
MESGSTPPTDKQIRENEQDGTGHQGKLLARPTSTRQQQQQQQQQPSHSVSQSVSQSPQTQDCLTIVANMSADQHLQALTKVVVNNLENQHDWTQVQIHIQDNLPRPLIYGLPPKRLYVHPDEQIDIIRAEKQLNQRVPQEPELEWVLPLHLAEKWSISDFAAVFDAITALPPGGESVNANEDAQWQLWRGPKRGKRILLATVQDDSTVTYYWMHNGLVKPRQN
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MSSEKLQHARNGAGGDHESLSHAPLPESPSQAPALTSTSQSEAVSTEHLVWASLIKEQHRYLQAAVQSGVSGSGTAVTAMGALSCLTASAPPPSYREELKAWRCTLTGEAAAQRLSAYAEAMHHLATLYWNPSATPLAGHSGGADDSGRARVEPGAHGGRAGAFESTAPRLGEKRKRSSDTAGGVQTPPSAVVIGEAMPATVTATMSDTHSRHYSDRLGYCLQSIASYYLGEAETEGCGEGTADGAPHAADCRPSAAAQSPSPPCFRVCVEQTRFRQLPGVFARVVKPLRRLFFQRYGRMATEAEVGQLISVCTPSRDDSCSIAPKKSRAGSFSCSSSSTDSSGGSTTAVCAARQLIDADVDARAIVEESTWRRSEHTAWATALHYTRGAPHPTPTSAPAPLWTLDVGSCYGPFFGTILSRAAPLAPVPLHVTSMDLAPYQGAAGCDTGSNGVPSPCVWRADWLQMEFFAEEPETDEAVRGCSTGVAFGTAEEGRVRYQRQRPASSLADGGGNSGLHPCDSREGSAGNAAQRSLAATAVRLESYDAVFFCLLLSYIPTPRLRFLACIHAFLALKEGGLLVIVSTRTQGPRRRNWMSEWTACLASIGFQRVQQSIQEKLVGMSFAKVSPSAEVRRSWATAEGRAAWIESLMTSSAALEGLRITADDARSCADI
The following text describes a protein:
Function:
[Isoform Holin]: Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of nanometer-scale pores (pinholes) causing host cell membrane depolarization and endolysin refolding and release into the periplasmic space. Once the pinholin has permeabilized the host cell membrane, the SAR-endolysin is released into the periplasm and breaks down the peptidoglycan layer. Determines the precise timing of host cell lysis. Participates with the SAR-endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell (Probable); [Isoform Antiholin]: Counteracts the aggregation of the holin molecules and thus of pore formation.
Miscellaneous:
MISCELLANEOUS: [Isoform Holin]: Antiholin and Holin ratio is about 1:2.
Subcellular Localization:
Host cell inner membrane; Multi-pass membrane protein. Note=Classified as a class II holin.
Domain:
The N-terminal transmembrane domain seems to be externalized during the pinhole formation.
Sequence:
MKSMDKISTGIAYGTSAGSAGYWFLQWLDQVSPSQWAAIGVLGSLVLGFLTYLTNLYFKIREDRRKAARGE
The following text describes a protein:
Function:
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MGVMRLKLVMKSIVLIVMARVLGIYDLIIAAIISAGINPKAKPKPYFLDGYTHLSFELACSLAGLAAGMAISIVRDTRVRIQQLEEAAVKRERAMAYAFNHQWRARSATSLGNFSYEVASLTDQKKPSPSPSSDQKKPVPKEQRAKEAKAYAQENGLFFMETSAKTATNVNDVFYEIAKKLLQGQQVQNPQGGMVLNQIPPERMSVKLQSVTCRTSDRMN
The following text describes a protein:
Function:
Probable G-protein coupled receptor.
Miscellaneous:
MISCELLANEOUS: Mediates sensitivity to N,N-diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLFQKTLSRVAAPISVAANLILILLIIFKSPAQMGNYKYLLIGLSIFEMSYAVLDVVSETTVLSIKKSFVVVVPYKDRSFGQETAMDINLIYCGFFGFSMGMFVVIFAYRSFLTTGNTILRKFEGFKIISWFAYPLFYAIVWILVAWGPLASFPEMDIVVRPFLLDELNMTVDEVAYTGRLFYSTIDNSLRYSAILTGVLQWVLTASSLFLVIFFGLRCYFHYGKLVQLTDVQSIRLRQLQNQLFLALVCQATVPLILMHIPVTILYTCCVLNIVFNPFSVATTIALFPAIDPLPTIFIVKNYRVALFEFVCPSCLCWSETLKHMGSNRITSYRSNTVNALSM
The following text describes a protein:
Function:
Probable non-lysosomal thiol-protease.
Sequence:
MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGQTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIRQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVHPCHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRSGWEEIISLWNPWGWGETEWRGRWSDGSQEWEETCDPRKSQLYKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRNDAQFNFSVQEPVEGTNVVVCITVAVTPSNLKAEDAKFPLDFQVTMAGSQRFREKFPPVFFSSFGNTVQSSNNKFRRNFTRTYHLSPGNYVVVAQTRRKSVEFLLRIFLKMPDSDRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSLDECRSLVALMELKVNGRLDQEEFAQLWKHLVHYQHVFQKVQTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEMEWMSLVMYN
The following text describes a protein:
Function:
Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 1560 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein. Nucleus. Note=Translocates from mitochondrion to the nucleus upon apoptosis induction.
Sequence:
MLLRFFINQPRFIQFTFLRNKKDRILGLQLGKQPFRMSSSSGLKQQGLAQKKKFQLEFDPSSVSKNGTKTEAKVVGTEFGVLLVRARNTYFATAGKCSHYGAPLAKGVVTSDGHIVCPWHGACFNAATGDVEDTPAIAALRTFPVTEEGDGSLWIEVEDKNDNGASVLQPEGCWRNKATEVYNKGSVETEVTAPHVCIIGGGKGASVAAEYLREKNFKGKITIFTREDEVPYDRPKLSKSLLHDISKLALRSKEYYDDLDISFHFNTDVTKIDLAEKKIYCGSDEKPTESYTKLILATGGEPNKLPIPGLDSKNVYLLRSIADASKLAAVTTEAGDKKNIVIIGSSFIGLELAVVLKDHNVSVIGMESIPFEKVMGKEVGTALKALHEQNGIAFYLENSIKEVKTSSNDSSKAEHIVLKDGQSIPADVVILAAGVKPNLRYLGNAVSLEKDGGVKVDEHCRVLGAEDVYAVGDIAHAPFAGLPSSGEKSHTRIEHWDVAGNLGRVAADHILFGNKAGYTTKSFTPYFWSAQGKQLRYCGNNAAEGFDDVVIQGSLSDYKFACFFTKGEKVVGVCSIMKDPVVSQCARLFIKDAMPSKSQLKENFDVLSIPL
The following text describes a protein:
Function:
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Sequence:
THCLTTAAGAPVARFSTVAGERGAADAERDIRRLFSYGDAARRLGVNHQHIPVNAPR
The following text describes a protein:
Function:
Transcription regulator. Associates with chromatin regions that are associated with ethylene-responses in absence and in presence of ethylene. In the presence of ethylene, promotes histone acetylation in an EIN2- and EIN3-dependent manner, mainly on H3K14 and H3K23, thus regulating positively ethylene-responsive genes.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Note=Observed in nucleoplasmic bodies.
Sequence:
METTPETQSKTHRLPAGREDWWSEDATATLIEAWGDRYVNLNRGNLRQNDWKEVADAVNSSHGNGRPKTDVQCKNRIDTLKKKYKTEKAKPLSNWCFFDRLDFLIGPVMKKSSGAVVKSALMNPNLNPTGSKSTGSSLDDDDDDDDDDEEDDDDAGDWGFVVRKHRKVEDVDSSEGSAFRELARSILKLGEAFERIEGKKQQMMIELEKQRMEVAKELELQRMNMLMEMQLELEKSKLGKRRAASGKKL
The following text describes a protein:
Function:
Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.
Subcellular Localization:
Nucleus.
Sequence:
MNIRMGTKGKRPLRSLTPRDKIHAIQRIHDGESKASVARDIGVPESTLRGWCKNEDKLRFMSRQSATDNLCADALGDKMDGGGGGGGGAGGGGLLGPPEKRQRLDGALPLNFSNKLKFDELAFKRSPLNGLDYSTNKNLADLGYNGLPVDYAAFNGGVKAKVFGADINRPAADPSLNAISPLSSLTHLSGLTGISQSPLAISFNELTTNLNLLAQLNPGLAAMSGLNSFPAGAGNLRTPKPSGQTPLQVQSPRSDSGDRSAQGLSVKNWAKQKPGEGQGSLNLSIKNEGKGGDIKSPSPSIAPSQMGGPMTLSNLAEDPLLYWLKSQQTMLGLNPLYPPTIPMGVTSPPIRSSTPQHMSQLAQTPPIPSAPLTPSSTPSGSLDEKNAAWYNWCKAFGASLHTLNPNAATLAALQANQLQQQVATTAAEGGSMGDPSNILYSHLTKETETPSVRSLSSNEQNPEADEATETDLDGEVEPEASGKPEDLSAAGKVMTPSQSPIAHSSGSRSPEPKAKTKTPETTNSTSECKKILDNMLFKMGGMEATGPLMPEQGSSESEGSFQDTSNPHTNNNDVSASNNNNNNNSNKTDEEEKAKYLDCTADEDIEAIRHGEKFLQWLENCSNPRVTAVQLMQLRFLIAAIKSGNETPMIEKSALPEDSEEHAAEEEGSGRGKSRRRK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MSLLEPTSCDMKDAEELLHAVTLRMSGGDPLDSYLDYFKAQGQSQCTNVWSKGIIAYRCRTCQTNDSSAICVVCFKKGNHWDHDYVMYHSESGGCCDCGDRAAWKESGFCSAHQRVQVLESKVKDELLEPTHFAVQHVLRELLAWVKKLLDKLLDDLNAEKTDLEVSMVMLYLEWSQKICAVDALRSIVCYDIVHYKILHQTDASTSPLEFLLDCLGWMPEKLIEAETTLYLQLLYKNEFKDQFLSILRVKYENMIFLAMGNSQYMKNYTHLDTNLDRVMVQLFNDPVFTTELIHKYSLLELFIGVFRRVVDCAAENPIDNIVDHDAIKCKVYLRPQGDLRLIVSHDDIAVHILTNEPELFPHFLGLLVKLQWMNSYDLSYDYDFDNSWTLAIQLEMNSMAIIFQLISRCYQSPLVREEALITAATYTFKALKQYLAQAMNTSKSVSLHIPLHRALSAILQKLVLLPWGNYERGFLTALKEKGAFNFSEDEVLALMDHPLAISVWMAQIRAQMWRRASEEFSRLELIYRGSFWHDQSMDMDILLLQFCTVACENLQGTIFIRIAERFNFKDMTTSRTIPKLPIRYITLLQDFMRLILLIVRERRNLGRTEEDEAQDKCLQYDVIQWLCVRDQTYSQLCRALSAIPMNHQKLNAMLEKVAVYHEPKVADRGYYQLKPEYWEEFDPLFPHYYLNELEEAEDRAVKVGKLDHYWRIKAPSAAGAPYDRLSGLLHTKACHLFLLNVLDEVRKLVGKDDTATAGEALGVTALQMMAVLVSDSCNKFRDADAKVQFQEPFDEYSTDDIFINIYVRIRIQGGPHLSIFQMLQEIVQANQCTRLVDSVRHVLELLCSSTNEKTHAAEVDSKGAEDMQRRLRKEQRQKAILDEFAAKRKAFMELQDDCDDDEEFEDGSEMDVSNTVDEASSCKTGTVSSSGALAKSVVPIAETEFLSMETSSEAKECVLCKRKKDDKNSSPCWIALVQRYNFPCQVLKRAEKVTNTGENTLVNDGSSHGLGLNGGLDQLITVGYSIESGNATSIDLSTVDHVQCCGHQMHYDCFKGHMKTLQMSYHPGNGVADPSISEFSCPTCRRLANILLPDVDASISSKRIDLHDDVKGVAETRQEWSGFWQANNNLKSAMECFCHQMLKVRKQSPNLHLNISSEFTISQALWEELALNVVHCEVETRDGFTMAESSSSSSAPSKRSEECIWGGDSAHWVALRDLGKLAILSNTLPDAVQDKGQWFNMLRRSLGLVGRRDKLSVADTATEPSPVLDGMDELERTIREIFPQNPLDFVETSELPESVDISIDSFHCQNETAGIQEDSGSSPLSCHLDMQEESEEVLIHTNTTQSELYEDNKYSSFVELNHGYTYSSRPAAPDPIAPDPQQKHVISFEDAKFEYEMREGNTIGNYSSCRSLPEREESILPEPQDTWMQDILKNGIFTTDPFRLLIVLLIISKGQPSRRTLLFMVKFAYTLAVLQTQIAVTRLDCEGSDVKSLVQRACLPFLRRAAILVQLATREYFRGQHGLSGTKAMDFLSLQLELQLPDCDLILQPYGATEALTTQLLSLYRRNRSTFELRKVPRKTLLHKLPRVFQELLLENIHNKKKCAACGEMPTDPAICLICGMLLCCGSDCCRKNGIGECSRHAAAESAGVGIFLLLRSTQLLLLRNNRTCMGLSLYLDVHGEPAQEDLYLRRSQLLYLSDLRLNEVRRLWMTAAFDYDSYILRNSQSRPKVY
The following text describes a protein:
Function:
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity).
Subcellular Localization:
Secreted.
Domain:
The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).
Sequence:
MALSITRGLLLLAALCCLAPISLAGVLQGHAVQETDDTSHQEAACHKIAPNLANFAFSIYHHLAHQSNTSNIFFSPVSIASAFAMLSLGAKGNTHTEILKGLGFNLTELAEAEIHKGFQHLLHTLNQPNHQLQLTTGNGLFINESAKLVDTFLEDVKNLYHSEAFSINFRDAEEAKKKINDYVEKGSHGKIVELVKVLDPNTVFALVNYISFKGKWEKPFEMKHTTERDFHVDEQTTVKVPMMNRLGMFDLHYCDKLASWVLLLDYVGNVTACFILPDLGKLQQLEDKLNNELLAKFLEKKYASSANLHLPKLSISETYDLKSVLGDVGITEVFSDRADLSGITKEQPLKVSKALHKAALTIDEKGTEAVGSTFLEAIPMSLPPDVEFNRPFLCILYDRNTKSPLFVGKVVNPTQA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MARGPTLRHASVATDRLQKIAVEGSSSPQKITTTTDDPMSTQKLATEELRGGGSSFDCNICLDFAQDPVVTLCGHLFCWPCIYKWLELHSNSQDCPVCKSALSQSNLIPLYGRGKTDISHSRKQLGSIPERPVGPRPGPAEPDHSLLDLRLRLLWDGHRPTCHVPNGGITGRNRDGGPAMGGGADWGR
The following text describes a protein:
Function:
RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
SSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL
The following text describes a protein:
Function:
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Subcellular Localization:
Cytoplasm, perinuclear region. Cytoplasmic vesicle membrane.
Sequence:
MSISMSRVLSRRQSSNSLDAERQNFERFQALSINKAINPNEVPVKEKHCRSTIIGTHQEKGAATFWKIVNTLPLQGNAIVCWKFCHVLHKLLREGHSHALTDTYKYVSHLADLGRLWGHLQEGYGKLIALYCKLLVTKIEFHRKNAAFPGNLQMSDEQLHAAGENDVNNYFQLTVEMFDYMDSILAMQAAVLSSVGPPRPLTSSVFATLDPTRSNSMTSTGQCRIAPLMPLILDSSHLYEFILKLMFKLHSCLPSDVLDGHRDRFLHQFHALKKFYHAAGKLQFFPTMLQVPQLPEEPPNFLLHCQDYSEHIAPVVVLPQAQSPDTDSLVDTDISPQTPSDLLQARPPQEDRRFEEVFGSDDLGTFQFNQTQNGAHENQFFPELQFVKLPEKDSKDIMIEQLQKEIQQLKQQMEYVQEQDQRIISSMNMRIRDLEFQLQQNMGTVREIREDNKLLVAQLERGGAGAQMQQRQKSDELEKQLKESEKRANKSGKVTKMKDVYTKLREEHIVLLRKSAEVERQLTHTYKSKDETEAAKKTAEEFAQRLQSSMDEKKSEEEAKTRQLLTEQLSLLVSAVEEGEHMVRGALDKFDDPLHAQSTSTAEYLISRAQSLLGSLDSLGRNYNSFTQNKKVTPDLVRTVTQFSHLAADTILQGKAASHMAPLEQGEDLAERCKGTGEKSLVLLGSLRQQGSAEVTSQQVEDVKASIQDMITCAQELIPKIADIKSELGDLVETEMSETTEAVDKAAAKIEEMLNKSRQGSSGVRLEVNEKILDSCTELMKAIKQLIIKSKDLQNDIVAQGRGTATAQEFYNRNPRWTEGLVSAAKTVGWGATVLTDAADKVIQGTGKFEELVVCSHEIAASSAQLVAASKVKAEKNSATLKELRAASKGVANATANVVATTKSGQAQIEESDTMDFSAMSLTTIKRLEMDSQVHVLELESSLTKERQKLSDLRKKHYQLAGVSEGWEEEDILNCDVVKRQESRQEDAD
The following text describes a protein:
Function:
Part of an ATP-driven transport system CT_067/CT_068/CT_069/CT_070 for a metal.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVASISPYYGVSFLEFFLVFFSRLFSGKLFYDHLYIDDIQVIVFFAIAVSCSVVGTFLVLKKMAMYANVVSHTILFGLVCVCLFTHQLIHLSMQALTIAAVSTTLLTGASIHFIRNVFKVAEEASTALVFSLLFSASLLLLVFLTRNAHVGTELVIGNADALAKTDILPIFLVLLINLGISYCFFSSFVCVSFDTIFAFSLGIRIRLVDYLIMLLLSASIVGAFKAVGVLMSLAFLLIPGLIAKLIASSVQEMMVYSMVFGGLAALIAPALSRSILSIYGIGLSTSGLAVGLLLVFYVVMLVFVCSKRAIMLRQKLDK
The following text describes a protein:
Function:
Has no transcriptional activation activity.
Sequence:
MSGRNRGPPPPSMKGGSYSGLQAPVHQPPFVRGLGGGPVPPPPHPSMIDDSREPQFRVDARGLPPQFSILEDRLAAQNQDVQGLLADNQRLAATHVALKQELEVAQHELQRIMHYIDSLRAEEEIMMREMYDKSMRSEMELREVDAMRAEIQKIRADIKEFTSGRQELTSQVHLMTQDLARLTADLQQIPTLTAEIENTKQELQRARAAIDYEKKGYAENYEHGKIMEHKLVAMARELEKLRAEIANSETSAYANGPVGNPGGVAYGGGYGNPEAGYPVNPYQPNYTMNPAQTGVVGYYPPPYGPQAAWAGGYDPQQQQQQQPPPQGQGHR
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MNGNPSRTYEYYKQHDDNDTPKTISQDIATAPWYTSGGEDGLDHLRISSFAQQVQTDRNVGIKHGYTSKKVSKWKPGCCKNCGSDQHTEKDCPERPRKVNAIVRGEGIYSGKKVYQQALSYEAKRDNYANYSGSRWLVDSKQASLYKAKILAQSTDVNDKVEIRATFGSRSSRNRQDTADYIKNIDNDTPDVLKEDSKFVGPEEGKSEKQEVDVKFSWEEGAVKPKKVTKDLTEEAMKQSQREFMERKKLMSTLIQQNEEKEEEIPKSERYGNMEDVFVNGHTSVWGSFFCAGQWGYACCKQTDRNSICTAQKD
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAFSANPLSLSVPEAAFETWLQETGYLETLDTRNIPPCVDRCTTSTGGATSFFSLFAFNPFSKLTVEDLKRQPASWTGEFFDCGLGPSRTYSLPSSVSQARLRIQENIRRYPRNYAYLSLLILCCFLYKIPIALFGLVSTVALWEVLRICSNRWQLEKYPVILHVMVLLMQLLTALILIYCKVVITLCWGVFVSFGVMILHSSLRRLTPSTQQADKKSKKA
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.
Sequence:
MSKKPIIYSVNCTPFKLHHPSALDMFDKIIDASKGKQFFMFLDYDDTLSPIVDDPDRAFMCDSMQRQELYYVGSHGMDIKGPTTTSKYNKDSKAEPILCQPASDFLPLIDEVYQQLVEKTKSTPGALVENNKLCLSVHFRCVDEKKWSELARQVKSVLKEYPKLRLTQGRKVLEIRPTIKWDKGKALEFLLESLEQKEMLRNELELMNKSLEESEAQLQSRTVESNELVSQIALLKKEEERSLDKLNRMKNLKYEKELADGRIRDANKVLNEMTESKIEAQNITGNTLINAYYKFGELKSALKFKNKLLEAGLKHDPFTYEALIHGFYKTNELERANELMINMVDAGFTPSYCTFSWIGDGYNKKDNMDAVLALPDDQDVLDLMRIVQKNRVVGATGLNERSTRCHSVLTVHVRGRELVSNSIVKGCVDVVDLAELDQWVAGRLIEDVWEIGVVMEGKVFTKNGLLKSWNLILVQEEGKKIRDNALKVKQTVQDATRPEGQAARDLKTLIEIISTTS
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MVENSSYRSEEDNLGGGGRDFLGKSVSEMDGVSKITPPSCQELTLSYLCENSKLGFVSYKGKEVMEESNKRWVERDFLQMNESSTSKGVNGNGNSSRHEEAEKIETPLNLSLALPDVSLSLAGSNRFDLQPSSHNNTHSASLSCSYSHPFSHNMSCSLTRNSTDFSVDHIWNCGEGTNGSVHSRFRPIPTNQVLPKETSDNISFFPSELPARPTIDDLQSPVKISRPERILREIVSESIPLMAQIVQELPHETLESTKEYLRNLIERKDDHLVVLQNRLNRRCDLTNETLTKCHKTQLEFFVAMKMGVGSFLSSKKVIPTTELAEIFLLERCRNINCMRGLPVEDCECKICSTKKGFCSECMCPICLNFDCANNTCSWVGCDACSHWCHAVCGIQKNLIKPGPTEMQFYCIGCGHASEMFGFVKDVFTSCAKDWGKETLVKELDCVQKIFQRSQDFKGKELHLKADELRIKLQKNMISPPDVCNFIIHFFNYTEGLSEFPDKDFSGRKKDVVSLPASTTVAPKSSPYNISSSSGRKDVIFDEHHQQKDVKPSFMPEKIVEDEWSVKRLKKDELASLESIVRIKEAEARMFQNRADDARREAESFRRVARMKSEKLDDEYSEKLARLCLQETEERRRKKLEELKVLENSHCDYYKMKMRMESDITGLLKRMEATKQLWV
The following text describes a protein:
Function:
Participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA
The following text describes a protein:
Function:
Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. This protein is one of 10 proteins (RAD1, 2,3,4,7,10,14, 16,23 and MMS19) involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Sequence:
MYRSRNRPKRGGENEVKGPNSALTQFLREEGISAENIKQKWYQRQSKKQEDATDEKKGKAEDDSFTAEISRVVEDEEIDEIGTGSGTETERAQVSYDARMKLVPADSDEEEYETSHISDTPVSLSSANDRESLTKKRQNTAKIIQNRRRKRKRAADLLDRRVNKVSSLQSLCITKISENISKWQKEADESSKLVFNKLRDVLGGVSTANLNNLAKALSKNRALNDHTLQLFLKTDLKRLTFSDCSKISFDGYKTLAIFSPHLTELSLQMCGQLNHESLLYIAEKLPNLKSLNLDGPFLINEDTWEKFFVIMKGRLEEFHISNTHRFTDKSLSNLLINCGSTLVSLGLSRLDSISNYALLPQYLVNDEFHSLCIEYPFNEEDVNDEIIINLLGQIGRTLRKLVLNGCIDLTDSMIINGLTAFIPEKCPLEVLSLEESDQITTDSLSYFFSKVELNNLIECSFRRCLQLGDMAIIELLLNGARDSLRSLNLNSLKELTKEAFVALACPNLTYLDLGFVRCVDDSVIQMLGEQNPNLTVIDVFGDNLVTEKATMRPGLTLIGRQSDSI
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MRSSRPEPDAPEPLSAHPQPLSRSSSSLLGEGRGQRPEYRKRASSTVCQAQLGEAGTGAQVPEAEGQQAERVEQAQASSPQLQPSAVGHWRSSTVGNVSTVGGSDLCNPWDPSAAAVQRSHSDLAHSTQTRGHSGAQKASLSCSALGSLPVHGAQLQPSSTSGQSGQTPEGLERDLAPEDKTSNSAWTLESQVWVPPAALGGTVTHSSSPKATGQSATTSCHALSPAALLCGMREVGASSCCHGLPAPGILAFPKLVASVSESRLQAHHGVKLQCRFSGGLPGHSHCCAHPWGPTGLAMEPSARTKDMWTMTSASDLAPVLASPLSAQDAGVQAAPKAVCKAVATSPPLEAPVALRMFPEVTLEPSLAEAPSPVRDVRWDAEGMTWEVYGAAVDPEVLGVAIQKHLEMQFEQLQGAPASEDSLSAEGRRGPLRAVMQSLRHPSCCGCSSAAPE