lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphatase that regulates diverse phenotypes in P.aeruginosa via regulation of the concentration of cellular c-di-GMP (By similarity). Acts by dephosphorylating the membrane-anchored diguanylate cyclase TpbB at tyrosine and serine/threonine sites, leading to inactivation of TpbB and reduced c-di-GMP production (By similarity). In vitro shows phosphatase activity toward p-nitrophenyl phosphate (pNPP) and tyrosine phosphopeptides. Can efficiently dephosphorylate two phosphorylated peptides derived from the periplasmic domain of TpbB, with a strong preference for Tyr-48 over Tyr-62.
Subcellular Localization:
Periplasm.
Domain:
Adopts a canonical dual specific tyrosine phosphatase (DUSP) fold, similar to eukaryotic DUSPs. Conformational changes occur upon ligand binding.
Sequence:
MHRSPLAWLRLLLAAVLGAFLLGGPLHAAETAATRSPAWAQAVDPSINLYRMSPTLYRSALPNAQSVALLQRLQVKTVVSFIKDDDRAWLGQAPVRVLSLPTHADRVDDAEVLSVLRQLQAAEREGPVLMHCKHGNNRTGLFAAMYRIVVQGWDKQAALEEMQHGGFGDEDDMRDASAYVRGADVDGLRLAMANGECSPSRFAVCHVREWMAQALDRP
The following text describes a protein:
Function:
Metalloprotease that shows high activities on basic nuclear substrates such as histone and protamine.
Sequence:
MRVTTLSTALFALASTAVSAPTAGSSSPGLEVKLTQIDNTRVKAVVKNTGSEEVSFVHLNFFKDAGPVKKVSIYRGQDEVQFEGIKRRLRSSGITKEAVTSLGAGETLEDEFDIASTSDLASGGPVSIRSHGFVPIVVDGKITGYIPYKSNDLTVNVDGGKAAKVTKALSQLTRRTEVTDCKGDAESSLTTALSNAAKLANQAAEAAESGDESKFEEYFKTTDQQTRTTVAERLRAVAKEAGSTSGGSTTYHCNDPYGYCEPNVLAYTLPSKNEIANCDIYYSELPPLAQKCHAQDQATTTLHEFTHAPGVYQPGTEDLGYGYDAATQLSAQDALNNADSYALYANAIELKC
The following text describes a protein:
Function:
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is required to anchor melanin to the cell wall, for maintenance of cell wall integrity, and for proper cytokinesis. Chitosan offers an advantage during infection as it is less readily detected than chitin by host immunosurveillance mechanisms.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRPRSSLVTWSKVPPPEAWFHTLVRLADLNSRTGKSDFSRQASHPERLRVAKRLSVSRSRRTDGAVRVGCSRGGRAITIRAFGLLYNRRLISDQYSFFARPAGSEKRDGENSTPLEVTTLPSSRPTTYAVDMADEGSLPPALAESRNCGAKYFPGLGETHNGGPVKTSSPRPKFPTTRKPGQINTVEQFYELRDSEMDTRILRLSTKLHDSDVGKQHEGAVLTIRLLYKQSRYKLYRPLINVILANEVKSDEEIFQFIEQKFNAPHSSLLSSMVTSGLTNSSTKHSSFMPALNRELDGSMYTNVPGLVEYFINIQHIDPTLRLQPHESFIKKKCEEKLEDKPQDIMLRWIASIFEQLGEESHSRGWQSHPTTRMEDIRYAIRRLDGAIMYRHVEAGNHIQNIMVPFELKKNTSDAREAAIDLAKYVYQVFNHQPTRSYVIGLTLCGTSMQLWQFDRCGAIGSESFDVQANKENFEKFFSLLSSLLTCNHQDLGFDPTFMDVDGQACSNTSEWRKIRYTTQDDPQELVIDSRPIFRASGICGRGTTTWKAHLHGDERQKYLIKDSWQPEKHEQEGDMLCKVAGLNIPHLVRYHHHEDVQVAGNRVDIKSHVRRQFKFDKCKTFTLGSGPKQPQNVFNNRFLRRIILKDVGQPIWTVKTPVRLLEALEGCIIGHQDVAIAHGELNDDKHHTMIGTKVFMSASLLLNKNHHSHVDDLESFFWVFVWFCIHFPDENSERIGVLNWNQHSRFDLGCIKAQHLHDPHPLMMHFAPRYKESPLLLECVANFAKIFPAIDHIDRDHSYDLETFNIADERSLPPALAENRNWNYSPVCRHLGLSSNIDILSLTRAMLGFDHYHHLFTIGIAFPKLVVMSFKGFRTGKSIKSEAEEPSEELSLLKDSLSNPGRRRSYESAEDGEIEEGGHSSFLPTTTSTHRRHQFKFKRPAKKSPTILILTCLIILSVTLIISLYLGLIPSFEAEHPSHQINWNRPPPRNRQWSNYYGLLRPKIGSKEWKMLYPPSKPAGPRPLESWIKRYDYLRSISSSNQLDSPLFTNWTNPQAKLSMQTGLAEYPEGTIFNSDPNGICSYRRASCLRGETEDRGIGLQDIWLGKNHTWSINFDDGPLPPSTSLYKFLDQQDETATHFWVGSNVRDYPELALQAWKRGDHLAVHTWSHAHLTTLSDFEILGELGWTIQIIHDLTGLVPLYYRPPYGDVDNRVRALAKHVFGLTTTLWNCDSSDWSLNQTFALGDFLDPPMNGFGVQESVGMINGHINQPDKSVGKIILEHELSFESVEAFKLTFPNLKRNSWSTCNLADCLDLPWYQ
The following text describes a protein:
Function:
This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Sequence:
MAATSSQSLYQSAAIFAGGLAIGAGTLALSRAAFAPAHKPNKSIKRKVSDAKLRTADASKSSSTAVTAKNTATALAGITADGRTDPPASQQLDHVDAKGAGPAAPAKPELPGHVAPNGVDATAGGQKLTGLVNAQPINAAAPEPEPANRAKHVDARMDLSTVQGPSEAETAAKIAAQSWLLGISSTKLTSTAAIDSIAYGNSTAIFSYESQANGGFGSFSEQEAQLAAEKGWFKGRPSVFKMQTRSGAGNAIIGYLNAKGGSSSTEPTKVVTALTNAAGFAAMAPALVSYHGSDNAKLVLQVSAATHAAEHGQELNITNDYASILSTAAALGDSFEVVLSATRQEAVDLAQYAYQSPKNVVHIFDGAFAGREVGTLNIPTKGQKVDAPEPFLFTGSPKAQTVLVVPSGSHSQAARAVLVTLPPAVRHNVALLSVRSLRDWDEADLRKALPKSVESLHVLEEVSGGVVAGQLYEDIVSSVFDVEFAGSDIPSHVFPLALAPGQNLTAAELSKLLETLSGNHNAALKLQDVIDEADGDHADLLALSGASVLSFFDSEISPTAPLAQLTARAIRDRGSDTQLHARLLSRYDNFEASGILRSDIILSSRPESAADAPIVLAAEENVAKVLVVSDPATTLRSYAPFQSLARGGTVIFNTPGWDVAELDSKLRAEDKRVLAQKSARLLLIDAAAVVEKLNTKTANASGGKAKVGDNVVPAEIAAAVLLVAVLRVQLNISGAALAAFLKRVIGTAPVGINGVEGLVLAAESAIQLHAFNDEEWSRAEPISEAEQNAPLRPTQIRYNGFGPNPDAATVGIEAAPFRSTWAQSAWQHLFSEAYDTKLDSLRPDLPEQTWVVEVTENRRLTPVDYDRNVFHMELSTKGTDLKYEVGEALGVHGWNDEEEVAEFIRWAGFDADEIVNAPSLTEAGKHESRTVFQTLQQNLDIFGKPPKRFYEELGKLATNRDEARWLRFISSAEGSYTFKKLSEIETLTYADVLRMFPSARLPVDQLLTLVEPIKPRHYSIASAQAAVGESIHLLIVTVDWKTPSGSPRYGQCTRYLSQLKPGAKVTVSLKPSVMKLPPIDSQPIIMAGLGTGAAPFRAFIQARAHKKAQGIDVGPLVYYFGSRYRSAEYLYGEELEAYTQDGVIQHMGLAFSRDTSKKVYIQHKILEDGDLLTQYLGPEIEKLEAAGGKAEVVLQDGLINDEDVEEGKKGYFFVCGPTWPVPDIHEALVGAFVKKGLTKDQAEKKMEALKEDERYVLEVY
The following text describes a protein:
Function:
Single-component hydroxylase that is part of the gamma-resorcylate (GRA) degradation pathway. GRA is initially converted by GRA decarboxylase to resorcinol, which is hydroxylated by resorcinol 4-hydroxylase.
Sequence:
MSAFAQPPGAGRKAVDVAIVGSGPTGMALAALLGCQGRSVVVLERYTGLYNLPRAAAFDDETMRTFQKLGVAEKMLPGTNVQRGYVWVNGDDEVLLDIEFDNPGRCGWPAQYMMYQPHLESVLDELITSLPTVEIRRGMTVESVDQQDGDDVLVRATDVEGSAYLVRARYVVGCDGGNGVVRQFAGGELDDYGFFENWLVCDFQLNRDVPDLPTFRQVCDPAEPIAIVNIGPRFHRFSFRLESAANREEVVHPDKVWPRVATYLTPEDAELVRVANYTFRSCITTQWRHRRILLAGDAAHQMPPFLAQGMVSGIRDARNLAWKLDMVLAGHPDSLLDTYQAEREPHVRYITEKAIELGRVQTMRDTALAAQRDAQMIAARKANQKPDKLRYPALSGGLIANHGDMFPQGLVSTSSTTALFDEIAGTGWLVVADGPQVLSGIAEGDRTAFTEIGGKEVIFGLTSMFDGAPVSDTAGVYTRWFAAHECVAAIVRPDGYVFGLARDAAELAGLAKELVAAVAPVPSRPPAPTA
The following text describes a protein:
Function:
Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAWAERLTGVRGVLLDISGVLCDSSASGATAIAGSVEAVARLKQSPLKVRFCTNESQKSLRELVGVLQQLGFDISEEEVTAPAPATCQILKERGLRPHLLIHEGVRSEFDDIDMSNPNCVVIADAGEAFSYQNMNRAFQVLMELENPVLISLGKGRYYKETSGLMLDVGGYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAIMIGDDIVGDVGGAQQCGMRALQVRTGKFRPGDEHHPEVQADGYVDNLAEAVDLLLKYTDK
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MTEQNGRRGGRGDGASQESDINERRELRRDYRELIAETKRESSELVRPDSDGLGNLLERSDELFGQVIKLPNRAPTVEAVLDAQFLMAASSLGCQKAKKIHVDNKFDPKDFVQKLISFMECRRLGIEDSEIEEEHWATLGRGAAPAFRSACSFQFMLGTFEREPPRKAARKTKDANAEEQAGPAIVAKQLKSKDKDKTPTEVTSEEVEKMVAILHQVCKTRGDGTYVPISYFDLVINPESFSQTVENIFHLSFLLKDGHAKVYLDNDDLPVIVPCTPFNEEQEHERVTKKQVLVSIDMDQWKELIEVFDINDPLIPTRPEPPHSNGNM
The following text describes a protein:
Function:
May negatively regulates apoptosis.
Sequence:
MSLEQKSQHCKPEEGLDTQEEALGLVGVQAATTEEQEAVSSSSPLVPGTLGEVPAAGSPGPLKSPQGASAIPTAIDFTLWRQSIKGSSNQEEEGPSTSPDPESVFRAALSKKVADLIHFLLLKY
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFRNQYDSDVTVWSPQGRLHQVEYAMEAVKLGTATVGLKNKDYAVLVALCKPTSELSDTQRKIIPIDDHLGISIAGLTADARVLSRYLRSECLNYKHSYDTTYPVSRLITNLGNKMQTTTQRYDRRPYGVGLLVAGYDERGPHIYQVTPSATFFNCKANSIGSRSQSARTYLEKNLNKFLDSSKDEIIRHGIRAILGTLPTDEQGKDAGQYDITVAIVGKDQPFTILSNKDSAKHVAIAKENDNDTPRNDDDDDRPSPPEEPAAGPRDPEVLVATEQRP
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAEDSDGRHDAASEGPPWDGLQSAVRRVGGGESEGGEFTRVDDDEQPSAEASEPELLPEDRHQTATPRDHEAGGPTAATQPTPGGVAAGASSDPDAAGGGIGMDAPESDEEAPLGEHIEEMVTRLGIVVAIAALVSIVVFPVTKPLITWMWNYVLPGGEAIDPRVYQPLELIITQVKVASLAGLVVALPAFVYESYVFMRPGLYRNERRYYLASVPTSLVLSVVGVLFAFFIVLPYTMGYFQSYTEPTADVAFALGTTFNLLLLVMGYLAVVFQIPLFIMLAIMLGVTTREWLESRRLLFWGAFAGIAFTFSAIDPTGIVPVIVAITMVVLFEGTLALLRWTGN
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. Required for the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Sequence:
MYNPYQQQGMGYQQQQQQQQQQPNGFYPQQQQGQSSNQPQGQPQPQQQMAFNQPQATGIGGMPQSFGNSFSSMPQQPQTGYNNNGNNGSVYGNGNFGQQPQQQQQQAKPQHTGYVPNSSMPMMNTTGTMPPPNPAQQPQLQSIQPQGTGYYQAANTANVHSVQPLQSQGTGYYVSTPNLISSNQTQQPLQAQGTGYYQSQPQQVPPPQQAQSLQPLKPQQTGFYLQPQNQAPLEPLKPTATGFVNSFANNGLNNDIKIPAIRLSFITAQDQAKFETLFRSIVTNGSNTVSGANCRKILMRSGLPPSQLARIWTLCDTSKAGELLFPEFALAMHLINDVLQGDTIPYELDSKTKNEVSSFIDAINLSIANQDSSANDAPKTPFDEFITAGVQNLQPQPTGYMPQTSFGIPLQSQITGGGVASALNPQSTGFMAPTTFNMSMNTGTPGLNPQITGGAPASMQPNITGNALQPQTTGMMPQTTGMMPQTTGMMPQTSFGVNLGPQLTGGALQSQYTGGYGSVMPQQSGPASMPNLSFNQQGLQSQLTGLQPQPTGFLPPSNFSATMPLTAQKTGFGNNEIYTKSNFNNNLIDNSSQDKISTEEKSLFYKIFETFDTQNKGLLDSPTAVEIFRKSGLNRADLEQIWNLCDINNTGQLNKQEFALGMHLVYGKLNGKPIPNVLPSSLIPSSTKLLDNLKNQLKTEPTTTKEKPSFGKIDALSYKNNDDDVLPNYRNRRKVYSAKNEEQSSFSSPSAKSVNHSSSTLQTDDISVDKTVEKKTAKPKYAGFSREINLKNIASLENEIKNISNPENCYDSSIPSDLTSRFDAIIAKLPNLFNEISTIDNEITNAKIQLYRKKNPSSIIGSGPNGEITENDRKKAKSRALLRARMSALTGKSTESEDSLSMEDEQQSAEIKRIQQENGKNQEIIKDIRSSISDISASLKSTMTGSNMISNQEFERWEFGIGLEDGVREFLDDLKSNSNKSVTESSPFVPSSTPTPVDDRSSSPSYSQFKTAEERAAYLKEQAKKRMKEKLAKFDKNRRNVTQSSRSISSENSREQPQQIAGSSNLVEPRATPFQEEKYVEVAQPTQPVQSTQPVQPTQPVQPTQPVQPTQPVQPTQPVQPTQPVQNVYNAKQESDDEDEDDEEKRLQEELKRLKLKKKADKEKRLAALRKQIEDAQNESDEEETNGKDNFGGHVNVPQAAPVAPSAAFSQNSTNAPRSVHAAVTPAAGKNSTGLPSTTMGHNPYFKDASASSTSTFDARAAEMQRRIQRGLDEDEDDGWSDEDESNNRVAVDNKVEEAKIGHPDHARAPPVTAAPLPSVTPVPPAVPVPQANTSNEKSSPIPIAPIPPSVTQEPPVPLAPPLPAVDGFQEPPIPSAPAIATAVQKSGSSTPALAGGVLPPPPPLPTQQASTSEPIIAHVDNYNGAEKGTGAYGSDSDDDVLSIPESVGTDEEEEGAQPVSTAGIPSIPPAGIPPPPPLP
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEKQAEKQLEKQLESFILHLKRKTVVGSYQVSRASAELLRQWVHKGKWGNAKSLIDQIKIIGKKLMNAQPLEFCIGNIVRRVLFIIREEYLTFFRNKKNGLNNDDYDDDDFETTTSNNNNNNNNNNINSSSNINKNNKYSNVMLQDDPIDDQEDIDFTETFPRLKAAIMDSINELIDELEGLHRNVAEQAIEHIHSNETIMTLGCSRTVEEFLKEAARKRSFKVIVVETAPSLEGQKTAISLSKASIDTTLITDSAVFAMMSRVNKVIIGTHAVMANGGLIATSGTHTLAVAAKYHSVPIVVCTGLYKLCPLYAYDQDTFNNFGSPGEYLKFEEAEFLENVHSYNPTFDYVAPDLVSLFITNIGGHNPSYIYRLLQEYYDARDILEDE
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMLAFLLLGALAIAGGILTVAAKNAVHAALGLVGTLICVAGLFASMNASFLAATQVIVYAGAIMVLFLFVIMLLGASQPITARDPLPFVGPLGAIAALLLAGGFVTLALTYQDPRPLAESVQALRGGAAGAVGETLLTRFLLPFEAVSILLLVAIVGSVTLVQRPVPQPDGVTDETGAELPPAPRAWREGQSAPALNSEPLKERA
The following text describes a protein:
Function:
May catalyze the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides and confer resistance to aminoglycosides (By similarity). In vitro assays show no significant increase of resistance to aminoglycosides, possibly due to low expression in a heterologous system.
Sequence:
MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLPIDISLDTSAELMCDWRAGDVW
The following text describes a protein:
Function:
Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.
Sequence:
MNLLISLLLLSISLVLGSSPSGGYAPGIVQCPINSNSNSSSSSSRNTTFSFIREADSISDLEKQWIKQRQLKVNKSLIEFLKSANLSNFNPQNFIDAKDYQGINLGLAFSGGSYRAMLNGAGQLMALDSRSSSSPSESGSGSGSLGGILQSANYIGGLSGSSWLLGSLAMQGWPTVEEVVFENPHDVWNLTSSRQLVNQTGLWTIVFPVMFDNMNKALSHMNFWDNNADGIKFDLEAKEKAGFETSLTDAWARGLAHQLFPKGKDNYGSSETWSDIRNIDAFANHDMPFPFVTGLGRKPGTTVYNLNSTVIEMNPFEFGSFDPSLNTFTDIKYLGTNVSNGVPVDSCVNGFDNSGFIVGSSSSLFNSFLNTLVCDNCNSLSSVIKWILKKFLTYLSKAHEDVALYKPNPFFNSQYAKSDNITTSDTLYVIDGGIGGEVIPLSTLMVKERALDIVFAFDSDTNTKTNWPDGSALISSYERQFSQQGSSSICPYVPDTKTFLEKGLTAKPTFFGCDAKNLTALEKDGVIPPLVVYFANRPYEYYSNVSTFDLTFTDEQKKGLIKNGFDVATRLNGTIDPEFKSCIACAVIRREEERRGIEQSDQCKKCFKNYCWDGTYASGPAENYVNFTDSSLTNGSTVFYGKADAKVSSSKGGLFGFLKRDTQNNDEKEEFIGVVRESNSDSLKLSKYLTIASLFALYLVIM
The following text describes a protein:
Function:
Transmembrane protein that plays a key role in trachea development by regulating crb localization and maintenance at the apical cell membrane. Required for anisotropic apical surface expansion important for tracheal tube elongation and lumen stability at larval stages.
Miscellaneous:
MISCELLANEOUS: Apnoia means lack of air in Greek.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Note=In tracheal cells, colocalizes with crb in the subapical region, a small region of the apical membrane apical to the adherens junctions.
Sequence:
MAANQKIVFALVCLFLACDLVLGQQQAANSSDSDSDVAESRTFGHHFLRRISFALVPGAFVVGVITTLLAALTVVSIKGLGVGVILLVLAIGQMLSRALPVQAAAAYAAAPVPVQAPVPVVYSHSHTQQPVWLEKEW
The following text describes a protein:
Function:
Proline isomerase that belongs to an abundant class of enzymes that catalyze the cis-trans isomerization of X-Pro peptide bonds and can accelerate the refolding of proline-containing polypeptides. Specifically binds nuclear localization sequences. May be involved in the assembly or folding of ribosomal proteins.
Miscellaneous:
MISCELLANEOUS: Present with 9490 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSDLLPLATYSLNVEPYTPVPAIDVTMPITVRITMAALNPEAIDEENKPSTLRIIKRNPDFEDDDFLGGDFDEDEIDEESSEEEEEEKTQKKKKSKGKKAESESEDDEEDDDEDDEFQESVLLTLSPEAQYQQSLDLTITPEEEVQFIVTGSYAISLSGNYVKHPFDTPMGVEGEDEDEDADIYDSEDYDLTPDEDEIIGDDMDDLDDEEEEEVRIEEVQEEDEEDNDGEEEQEEEEEEEQKEEVKPEPKKSKKEKKRKHEEKEEEKKAKKVKKVEFKKDLEEGPTKPKSKKEQDKHKPKSKVLEGGIVIEDRTIGDGPQAKRGARVGMRYIGKLKNGKVFDKNTSGKPFAFKLGRGEVIKGWDIGVAGMSVGGERRIIIPAPYAYGKQALPGIPANSELTFDVKLVSMKN
The following text describes a protein:
Function:
Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP (Probable). Involved in the degradation of intracellular cGMP, contributes to the control of cGMP signals.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The beta lactamase-like domain catalyzes the hydrolysis of cGMP.
Sequence:
MMFSKRKSIRFNPEGDYTELPRGGYVVPSKLGGIQFGVPPETIKDSMALKIDVPTIYVFPEELWDRKTGINAAEAEFPAYFNYFILKRKVSFVCTKEQEQRIRIVFQETLLGPPEFNTGIIINSSSSTTDTSKTSPIKKQTSSSSPPLSPQQQQPPPPLVKQPSQQQLEELATMDTCHYHHHHHHQEVNDNDNNNNTTTNNNNIEILEQQQQQQQQQQQQQDEDSTDVDEEFQKEFSSTFPRSEIPNLEKECKYLRTFNSVDELFDFILFDDNGIAKLSDDVEIHFQEDQSLFKVLQFEETGKGNKVQTLVATIPSKILFPDMINSISTINDNKIFDPPTFGITIIGSSHGFDPKKSTTGFVLWINKRGIMVDPPLNSSSFLQSQGVPTRMVDHIILTHCHADHDSGTFQKLLEEYQITVVTTPTILGSFLRKYGALSNLSTDLLRRLFIFRPVMIGEPMIISGAEFRFFYTIHTIPTISFEVFYGGKSIFYSGDTCYDPNRIKDMNKRGIMKTSRMKFFLRPWNHTVVLHEAGVPPIHTPVSVLRALPDEVKNRLYLVHISEHTLPAGSGLKIAKEGVAHTLSLDVMKSSHSEAVDILKLVESVDIFRSIPLTQACEILQTATKRKYSQGSVIIARDTEPDAFYVVASGVVCVNIGELKKNLIVGDYFGEMSLVMGGLRSANVQAVTDVEVLSFNKEDFLSITRNSTESIQFITRLWEMRNEKSWETMSLNSVFSRCTNSQKTAIQSILVRELIKKDETLWCKGEEALFGCLVAEGSFVFKEDDSLESFSQGSFLGDINAMTTQPPSIHKTTVVAKEESVIYKVLSQDLIKFFSNNPGIQLAFLDTIFVDALRDQVQQLVNSKLTY
The following text describes a protein:
Function:
May be involved in maintaining Golgi structure.
Miscellaneous:
MISCELLANEOUS: Antibodies against GM88 are present in serum from a patient with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Domain:
Extended rod-like protein with coiled-coil domains.
Sequence:
MAEETGQSKLAAAKKKFKEYWQRNRPGVPAAAKRNTKANGSSPETAASGGCHSSEASSSASSSLHARQSPCQEQAAVLNSRSIKISRLNDTIKSLKQQKKQVEHQLEEEKKANNEKQKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAGRLQRSSQRIGELEWSLCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQLKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQEVCTLKEEKKHDTHRVEELERSLSRLKNQMAEPLPPDAPAVSSEVELQDLRKELERVAGELQAQVENNQCISLLNRGQKERLREQEERLQEQQERLREREKRLQQLAEPQSDLEELKHENKSALQLEQQVKELQEKLGQVMETLTSAEKEPEAAVPASGTGGESSGLMDLLEEKADLREHVEKLELGFIQYRRERCHQKVHRLLTEPGDSAKDASPGGGHHQAGPGQGGEEGEAAGAAGDGVAACGSYSEGHGKFLAAARNPAAEPSPGAPAPQELGAADKHGDLCEASLTNSVEPAQGEAREGSSQDNPTAQPVLQLLGEMQDHQEHPGLGSNCCVPCFCWAWLPRRRR
The following text describes a protein:
Function:
Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium. Cell projection, cilium, flagellum.
Sequence:
MNRKKLQKLTDTLTKNCKHFDKFEVKCLITLFYNLVGDVAERPGVVTGLDRNVFRNILHVTFGMTDDMIMDRVFRGFDKDNDGCISVSEWIHGLSLFLRGTLDEKMKYCFEVFDLNGDGFISKEEMFHMLKNSLLKQPSEEDPDEGIKDLVEITLKKMDHDHDGKLSFVDYEKAVREENLLLEAFGPCLPDPKSQMEFEAQVFKDPNEFNDM
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
MMMMHPPEMLPAPGHEDAPLPKKADRVKRPMNAFMVWSRGQRRKIAEDNPKMHNSEISRRLGEMWKELSVEEKKPFVDESKRLRAKHMEEHPDYKYRPRRKMKNTMKGAKFSLPPLPGMPMQDYLSPGGTTGMPPPPPYPPHSYMNGYSMNGYYSSMMHDQFSHPYQRYPLIPPAPPAPESGSPDHDGPVDYSRAAYPYVTQSSSPYPVTCVTTTSAPEGTGSESPNSSPPSPRDTSSPVYTTAYTAPTSSYVASATAASYGGGPYAGPYAGLPGLPSRSVVPDIPHHRAPYPGDLQEMIRMYLPAGSAS
The following text describes a protein:
Function:
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (By similarity). Through production of PGE2 may regulate the activity of non-muscle myosin II in an autocrine or paracrine fashion; this may influence border cell and nurse cell stiffness to facilitate border cell migration during oogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAAAGLIPPPVSWAQRNDLIYVIIDVECKDIEHKVTEKTFTFKGVNVLDPSKKYEVTLNFLHEVDPEKVTSKNIGRCLEFTIPKKAAGPYWSSLTTDKTKLHFLKANFAKWRDESDDEEGDQKDNSMFGNFLNSPGGDWNNKFDDFNVDDEEEDSDDNIPSLSQNDEDDEEGGEGDKEKKPAA
The following text describes a protein:
Function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Sequence:
MIRAMTTPAAVIVDATAYAQAVEDAAHAAAAYYAGGSSPLDDDAYDRLARGIAAWEAEHPDEVLPDSPTGKVAGGAAEGDVPHTVPMLSLDNVFSPEEFTVWTASLARRIDREVTRFSVGPKLDGLAVAARYREGRLTRLITRGDGTAGEDVSHAIGTVEGLPGTLAEPVTVEVRGEILMTTAQFEHANEVRIRHGGQPFANPRNAAAGTLRAKERAYTVPMTFFGYGLLALPGTDAALAGRLEELPYSELMETAAGLGVHTSAGTAVPDVVVGTPEQVVARVQEIAALRAELPFGIDGIVVKADLAADRRAAGSGSRAPRWAIAYKLPAVEKITRLLEVEWNVGRTGIIAPRGVLEPVVIEGSTITYATLHNPADITRRGLRLGDHVMVHRAGDVIPRIEAPVAHLRTGEEQPIVFPEACPRCGSDIDTSEERWRCAQGRNCHLVASLAYAAGRDQLDIEGLGTTRVVQLVEAGLVADLADLFLLRREQLLALERMGETSTDNLLAALARAKEQPLSRVLCALGVRGTGRSMSRRIARYFATMDHIRAADAEAMQRVDGIGVEKAPSVVAEIAELAPLIDRLAAAGVNMTEPGATPPRPADTDGADGATAEAPGDGGPLAGMKVVVTGAMTGNLERLSRNEMNELIERAGGRSSSSVSKNTSLVVAGEGAGSKRAKAEQLGVRLATPEEFAVLVAGLLS
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MFLTKRVSSLVKTNNFKLNSSISSINSIRSLKDDQESQQQQQQQQQYYSTKRNVSSNLKKLTKKPTVVKSKTPKRISEMSRLLSKLTMEDPDGIDDSPIVGDDKEYNMEEDDYDNNDEENEFQFDSKLKFDTTQDNQLYKKENIQETEIDKNKEDNYFNNNNNNNTQNSSSSSDNIKKDKKTIDEEVRLEFWAKQMALRDSLKNDGGKYLLDEESYQEPIKNYKILGRKLMQRRQVEKEKEIDDKKKLKEKLKLEKIKELGLDLNLIEQENEKNKLKSEEALKDLLTKEEFESYKKSNNNNKNDNEEDEEGEEEEEEYDEEDDDDDGIYDNMIDGDRNQGLVDIDIGLPNLTRLNPYTPVPPPIEIVQELLEIRKQELIKKTEQSSDDFEKRRRIKRIEFIAKKKELQHKQMLERHKRMGLYDSIVTDEDELPIEIDPKVFSRYQAGDITEQEMLDISKIENKQERQRQIKSRIEAKNKKISKQDRNNNEVIIKGQENNEVNENINKEVENDDEEDDDYEDDEDEDEDDDDDYDDDDDDDFMKPSRKNTEFLRHWKIGSIGVPPLLKKKITSAIKEYPTGQLRNDAALLSEQLRSRTRLGKAIGSTNIVVKPEDRPVITYGKGQVLAYISHRMPGVYACTHRVFSEINSRLPNFKPTSLLDYGSGPGTVLWSADTIWGDSIKRIRAVEPSTYMSDVAKKLLEGNTNRVKWSPYLNTANLKRQDGTIPSTELNEMVTASYVLSELPSQEARNDLVRELWSHVKPSGILVLIEPGTPIGFNIIKEARQLILDEEPEILSIYKSTKAQVVAPCPHSGKCPMGSLSWCHFSQRVERPVFQKLAKGPHSTMPYEDEKYSYIVLSKVVHSSIQNQLEKQLQIYPTEELEPTKNWSRLIEAPLKRGGHVIMDVCSPNGSLNRVTVARSHGKQMYREARKSFWSDSFVVDPELIDHHEGRFNRNEEIENKLKQEEAEKLEEIKKQKKKSQSFLQDDLVDEDQDDDELSIENGDADGGKSLTKSEKKEKERRNNKDWMNELQGTDRRVLEKLIKQGKFTEKSGGLFGSQDNTPASDYGTNEMEFGFQEEDDDLDDENDDESYRKKKPMTIADFKETSKTRKLRKEKLQKDLNQFRKQTMSPEELKIQEEKENEIKNRSKIYKESNPKKIEYYLKNFDNENALVNQDTILQRQQNRLENQQTMRETFENIKNGLSIASNKDKLLKEKEKMDKFRKFKKQLEKQQNDVDNVD
The following text describes a protein:
Function:
Vesicle trafficking protein that functions in the secretory pathway.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Prevacuolar compartment membrane; Single-pass type IV membrane protein.
Sequence:
MFLQGMASFGDSWIQEYNEAGKLADDISNMISGRSSSPSTGPEAQRYSSSIRRKITILGTRLDSLQSIDSKLPGKQRLTEKEMNRRKDMLANLKSKATQMVSTLNMSNFDNRDSLLGPETKAADAMSRTTGLYKYGVVGLQRQIMKGKLLCYWFFCFFCMLSIGFSICVEQDEGFAKLEKTVMNTKHIALTVNEELDLHTRLIDTLDEHVDVTDSRLQRVGRKLAILNKRTKGGCSCMCMLLSVTGIVLLVAAIYVLIKYL
The following text describes a protein:
Function:
Putative transcription factor. Does not affect flowering time.
Subcellular Localization:
Nucleus.
Sequence:
MLKEESNESGTWARACDTCRSAACTVYCEADSAYLCTTCDARVHAANRVASRHERVRVCQSCESAPAAFLCKADAASLCTACDAEIHSANPLARRHQRVPILPLSANSCSSMAPSETDADNDEDDREVASWLLPNPGKNIGNQNNGFLFGVEYLDLVDYSSSMDNQFEDNQYTHYQRSFGGDGVVPLQVEESTSHLQQSQQNFQLGINYGFSSGAHYNNNSLKDLNHSASVSSMDISVVPESTASDITVQHPRTTKETIDQLSGPPTQVVQQLTPMEREARVLRYREKKKTRKFDKTIRYASRKAYAEIRPRIKGRFAKRIETEAEAEEIFSTSLMSETGYGIVPSF