lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), which probably acts intracellularly as a second messenger perhaps by promoting cell proliferation. Overexpression of sgkA leads to increased growth rates on solid media and an increased resistance to the antitumor agents cisplatin and carboplatin.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Determined in cells overexpressing sgkA. Also appears enriched in some pseudopodia.
Sequence:
MSINSDYNKENNNISPLNTSSERRSSLRNSLNNSSNNNNNNVINTPTANSINSSGNFSPKEFVSNIDGEEIIYQNQSVEYKQRLCTIQIKQSTLIIKFNEKGGFTKYLVSDTIVGSEITNESTNEYTIYSCVMNTLDVTKETRRRKQFSLRFRDRFELNQFNDKFVEAFLDTLPMGNPRERRIRVILNPKSGKKMSDSIFKDINELFKDSKIFVKKTVTKGPDHAKKIGYKFNLKKYDTIVFISGDGLFHEFINGLLSRTDFEQARKIPLALIPGGTGNGIACSIGLQDPMSCALAVIRGFTKPLDVSVIQQGDKKWCSILSLTWGIVSDVDIESEKYRALGDVRLILGAALRILNLRIYRGKIWYLPALELNKTEIAKIPKCSYSCEICESDNPISTIENVISQQQQNNTTTNQLRRSSLNNSSNGFSPKLNTSGSISNGNDDELRSMFSKEENIKIENEIHDHQNDDVLPLLKSSSDQHFIVPPTKLPNQQFLKETKEELFAKGWKVLEGEFIGIVASTVSHLASDFIASPTAHLSDGLIDLVVINNNKKFSKAGLLSVLTESSTGAHVKSDLIDQYKVQAMILEPSNDREGIIAVDGELISYGRTSMECMRACINLICRTY
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MAYFILHILGVILGAIAVLLTIIVTSMAQWRVSYMVEGNSMNCDKRIDGLYLSRWDGLWVTCVSKHIGSMDCHSYDSLVSITTDLKTGRVLMSFAVVISIIAFITAIVAFCFSRCCKGGEGSRFCLFITAGIGFILAAILVLIPISWTTSNIVIAINNPLCKTVQRQEIGEALLLGYPTILFLLITGAIFCCPYPRHERCDSIESCSDSSLPKPAYVQCQSQDRRPTQAHYSRSQYI
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate. Its physiological role is not known. Cannot use NADP(+) instead of NAD(+) as a cosubstrate. In the deamination direction, can also efficiently use L-2-aminobutyrate as substrate. In the reductive amination direction, also exhibits high activity with 2-oxobutyrate and oxaloacetate as substrate. In contrast to bacterial homologs, does not exhibit any ornithine cyclodeaminase activity.
Sequence:
METLILTQEEVESLISMDEAMNAVEEAFRLYALGKAQMPPKVYLEFEKGDLRAMPAHLMGYAGLKWVNSHPGNPDKGLPTVMALMILNSPETGFPLAVMDATYTTSLRTGAAGGIAAKYLARKNSSVFGFIGCGTQAYFQLEALRRVFDIGEVKAYDVREKAAKKFVSYCEDRGISASVQPAEEASRCDVLVTTTPSRKPVVKAEWVEEGTHINAIGADGPGKQELDVEILKKAKIVVDDLEQAKHGGEINVAVSKGVIGVEDVHATIGEVIAGLKDGRESDEEITIFDSTGLAIQDVAVAKVVYENALSKNVGSKIKFFRI
The following text describes a protein:
Function:
Component of the 9-1-1 checkpoint clamp complex. Involved in both meiotic and somatic DNA damage responses. Essential for activation of the meiotic checkpoint in response to double-strand DNA breaks; required for the S-phase checkpoint but not the G2-M phase checkpoint. Involved in double strand break repair by homologous recombination during meiosis; influences the organization of chromosomal DNA in the meiotic nucleus.
Subcellular Localization:
Cytoplasm. Nucleus envelope. Note=Localizes to the nuclear periphery when part of the 9-1-1 complex with Rad9 isoform A and Rad1.
Sequence:
MKFRALMQDPLYMKEFQAIVATLTKLAKDCVMILGSRQMHFIVNEDQSSAASPLVWAGITAEEYFPEYRMEAAHPDQEYIVLGVSSANLGRALSVLRGGGVNSCKLKLQRIQFPCISVIASVLTSSSTEAREVVHDVPVTIIPGSDWSAYVVPRVPNSQLALGLPSLRLLKSLIDKLKNISPSLEFQVNVDGELNVIATSEMSTVTSRFQKLLIRTVSGSQQEASCSVDSRKASAFFGALQLPNEELTIGIDREHSIHLQIDVRQDVVLHSILPAVCM
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein. It acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). The carboxylated form binds strongly to apatite and calcium (By similarity); The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Subcellular Localization:
Secreted.
Sequence:
YLDHGLGAPAPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGIA
The following text describes a protein:
Function:
Opens both the alpha- and beta-forms of N-acetylneuraminate (sialic acid; Neu5Ac) to provide aceneuramate, the preferred substrate for NanA. Has preferential activity on the beta-anomer rather than the alpha-anomer. Accelerates a reaction that is spontaneous at slightly alkaline pH, facilitates the reaction at acidic pH.
Subcellular Localization:
Cytoplasm.
Domain:
A His-tag on the N-terminus blocks activity, while a C-terminal His-tag does not.
Sequence:
MMMGEVQSLPSAGLHPALQDALTLALAARPQEKAPGRYELQGDNIFMNVMTFNTQSPVEKKAELHEQYIDIQLLLNGEERILFGMAGTARQCEEFHHEDDYQLCSTIDNEQAIILKPGMFAVFMPGEPHKPGCVVGEPGEIKKVVVKVKADLMA
The following text describes a protein:
Function:
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEHSTSNSPAPLPTPQRSTSISPANSTCSTSNVTKAPLYGTVIPNRVFVGGIAYNCSEQELRDFFSQFGAVRDTKIIADRAGVSKGYGFVTFDSQEAADKAQQNDNLMFKDKRLNVGPAIRKQSPSLPSPFRPESSCSPYLADIGPSTSFVNNWSLPYGYMCPDSYLPQQTIVGPSVPPSLSPAPIMLPAGPPTHQPCNMYMPQGPPQQSYYPNTAAGQQYSTSGREWAPQSPPAAMQAPQPMTFDGYGPVYQEMVPVEMNP
The following text describes a protein:
Function:
Orphan receptor that may have a role in planar cell polarity pathway.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKPAGRSGPVSERRRYAGRWRRRLVLGWVLWIALWESSPGATALPPGCKHDGRPKGASKPSAGGAAAAAALEGKVVCSSLDLAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISTIDPGAFWGLSSLKRLDLTNNRIGCLNANIFRGLTNLVRLNLSGNLFSSLAQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRETRCAYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSRRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGILVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTRRGNNTRTVDIVVLESSAQYCPPERVINNKGDFRWPRTLAGFTAYLLCPRNTPGSGIYPGNPQDERKASRSCERGGFWAKDNYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVVFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLWLAQREKKACSRIVQCLQRIAAYRLANGAHVYSTYSPNIALEAYVIKASSFTGMTCTVFQKVATSDRTGLTDYGRRDPDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSSKHKRETRLADESIYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKMDGINIDTQHIPINVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILSADENVTTIQCYSLTSYAVLMDLTGSEVYSQSADLLHPVVYATSIILLLNLLMIIISYIYHHSLIRISLKSWHMLVNLCFHIFLTCGVFVGGITQTKNTSICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIRNYGSRPNAPYCWMAWEPSIGAFYGPASFIIFINCMYFLSIFIQLKRHPERKFELKEPAEEQQRLATSEHGEVNHQDSMSLSLVSTSALENEHPFHSQLLGASLTLLLYVALWILGALSVSLYYPLDLVFSCFFGATCLSLSAFVMMHHCVNREDVRLAWIATCCPGRSAYSVQVNIQPSSSIGTNGDAPKCTNSSAESSCTNKSASSLKNSSQGCKLTNLQAAAAQCHSNSLPLNTVPQLDNSLTEHSVDNDIKMHVAPVEVQFRTNGHPGRHHKNRSKGHRASRLTVLREYSYDVPTSVEGSVQNGLPKSRPGNNEGHSRSRKAYLAYRERQYAQPQQDSSDAGSTLPKSSRNFEKTITASSKKDGVRKPIVVELESQQKSYGLNLAIQNGPLKSNGQDGPLLSTDSTGNIRTGLWKHETTV
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MTIASLSNRTNLSESDINELVTGKLSPADITEVLKRGVQNAKWDGLGVGKGLVAKLPDLNKWKEAIDGLDEEDNDNNNNSNSFNIGSSDGLAVLLRILLAGDPNGSLVAYFYQRRRWQRLALQVQLMNATAGISRERHQLDLAGCGLTKIISSSVIPPAMAAADSPMKPIVVALEASPLNLVDLVRLTFDAIERETVAESAAKDFLDKHAKVTPELFFLGSLKTPKPWSPLLERVIKNFFDLFFSGHNSSILVFSILGQQDEAFLASMVVEYYRVSALNVGKILDICHAANILPHVLQLRYFAFTMDLAVLASQRQLYPLKQFMDDTYKAVGADFVRGVLDFLEMKISVELSSQAGVGVPPPPPPQNPLTLSSVATILQFVSSGSDMPADRLEQFKMLQTQTFQVYPRLINFGQGHDQAILAHGDGSNAFPPHIEREMKLCYQRMYEEQIQIRDIITMLQRLKQSDDPQDQDVFACMVHSLFDEYRFFPEYPRNALAATAVLFGGLIYFRLIQDIPLSIALRYVLDSLKQPADSNMFKFGLQALYEFRERLNEFPTYCSILAEIPGLQSHQEIYSYVKQLAGGPGGGPGGPGVGGPPPGVPGGPDNSLAPETLIFSSIRVDSNLPEDAAQVEPPEELSDKVLFMVNNLAQSNVVARSREMAQVLEERYFRWFATYIVRHRAKQEPNYHSLYISMLKNMSNKLLESFFLRVTYLQIVKLLNSPETVSSSTDRNQLRNLGQWLGALTLGRNLPIKHRNISFKALLAEGYKHQKLVLVIPFVAKVLERAAKSKVFAPPNPWTLGIMHVLAELYHHAELKLNLKFEIEVLCNQLKLNVEELEQSHIIRGGSSAVDEVVDGVSKLNVDAANAGMVPPGAMGMHAGMPPPRGMHMPGGMGGPGGMMGPGGPGGMGPLGMGPGMPPIHGPPGVNQQQQQQQAQQQQAQQQAQAQAQVQQQGGAPGVGMRAAGAAVASAAFYDAYQNIIMSMELQGDSPFVSHPTLKQLFMLSVDKAVREVLQPVVERSVSIATIATRELVTKDFAFEVDCDKLRRAAHNVVRMLSGSLSLVTSKEPLKDSLLNNLKTLLLGQGYGEETLPLDQMAAAVAANADAICCVVEKAAIDKSLLDIEEALAASYALRQAHQGDAASFVDPQVTRFNLPLPDPLRIQPGGVTPQQMALYDSFSEGGAGLPSVPAAMAAVAGPGGQGAAAGVPAPSTPETPQAVLSQILLTVQARIDALLRSISAVTDGSAGPVPTSLVELPADHEIRVRLLQLLSLVSKSPYQNEVVLRTSQLVVNALFTQSDSQLSHESFALLLGKLCELSAETCKEVLLWLIHSSDKRKFNVPVVATLLRTRFITVTELDQSLAKQMLESRDVAAVEFTHKLIADVVLGADPCALRTDFSCCLIVLEALIKENKEGKDESKEEAKTKEEGKEVEPELSEEEKKAKEAKEAENKEKLAAAATEAAKCITTLNDTNVVIPTITELSESTRASRTDASQVSLKEQCAYIFAEWLRLVGHPGACNNLRMRYMFVLQLSEIGMLSNPDHLCVLVRTATEISVKSYCFEMVDKPAAPVGDVAVAVDGLAKLLVTIISAHEATNAKRISAFVRQLLAVVVLVFAGDHEAKSGGESPVGFNEKPYFRLFSSILCELSEAELSAESRDAIYLCLAETFKLIQPMAFPGFAFAWMTLISHRMFLPKMMDVVRNRRGWGPYLSLLEALLKFQDHFTTDKEFNEHVAVMYKGTLRIMLVILHDYPQFLIENHYPLCNVISPSFIQLRNLVLSAFPADLELPDPLTVGLKVESLAEIKAAPPLAIDPGHEAQKHGIRKLTDMYLRNPSPAIIKNLLKAFYLPSAKPCLGLGFNEISVDSTALNALVLYIASLISTATFDTSSPHLSLLTSVAVALDAEGRYFLFEAIANQLRYPNRHTYWYSCVILSLFGAHGEASLGSGKVDIQHIITRVLLERIICNRPHPWGLMITFAELLKNPSYRFWDLEFTKGSQEIEKMFASLNSHIMPTEGTE
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MGRAQQQTLTQGEHHPVPRPDQLLLPPSSLSPRPHSSFPPWEDRTAEPVHHQPTATRVAMAQPGRGRDPELFAELWRACAGPLVEVPQRGERVFYFLQGHLEQLQEPTDSALLAEQIKMFQVPYKILCKVVNVELKAEAETDEVYAQITLQPESDQDNLPLICDPILPETPRPVVHTFCKILTPSDTSTHGGFSVLRRHANECLPPLDMAMPTPTQEIISKDLHGSEWRFKHIYRGQPRRHLLTTGWSTFVTSKKLMAGDAFVYLRSETGEQRVGVRRLVQKQSTMPASVISSQSMHLGVLASASHALKTNSIFVVYYRPRLSQSQYIVSVNKYLQASKTGFTVGMRFRMNFEAEDVPVKKFFGTIVGDGDLSPQWSGSEWKSLKVQWDDSVAICNGPERVSPWEIDSSDASSPAISALLQSSAKNKRPRETNENFDLPSQEPTQEFWLSGMTQQHERTYVGSSDPNRISGYHQILWPSSEPAGYGAMSSSSVCQTPLGLGDGWPKDFNPSSQGVSPTLSEITQKLNRVASSEGRTPPPWATALCGGYRAEEPTSKLSCNPTLPLPEQVAPYLPKVAEKAKEPGVVRLFGVNLMENTNNAAAPTAGNASAGAGETSARVAGSVEGSGQLSAFSKVTKVANESPREIQSQQSNVGRNRVKVQMHGNAVGRAVDLASLDGYEGLTSELEQMFEIKDIKQNFKVAFTDNEGDTMKVGDDPWMEFCRMVRKIVIYPIEDDKNMDPRQTSVLAAAPDPDPKANL
The following text describes a protein:
Function:
Part of a cation efflux system that mediates resistance to copper and silver.
Miscellaneous:
MISCELLANEOUS: The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth.
Sequence:
MKKIALIIGSMIAGGIISAAGFTWVAKAEPPAEKTSTAERKILFWYDPMYPNTRFDKPGKSPFMDMDLVPKYADEESSASGVRIDPTQTQNLGVKTATVTRGPLTFAQSFPANVSYNEYQYAIVQARAAGFIDKVYPLTVGDKVQKGTPLLDLTIPDWVEAQSEYLLLRETGGTATQTEGILERLRLAGMPEADIRRLIATQKIQTRFTLKAPIDGVITAFDLRAGMNIAKDNVVAKIQGMDPVWVTAAIPESIAWLVKDASQFTLTVPARPDKTLTIRKWTLLPGVDAATRTLQLRLEVDNADEALKPGMNAWLQLNTASEPMLLIPSQALIDTGSEQRVITVDADGRFVPKRVAVFQASQGVTALRSGLAEGEKVVSSGLFLIDSEANISGALERMRSESATHAH
The following text describes a protein:
Function:
N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
Miscellaneous:
MISCELLANEOUS: Present with 952 molecules/cell in log phase SD medium.
Sequence:
MDENEFDNQRENKAVARVIISFLKYEEYALKEIYNLRVKKWASISDRQKDMVPNYTKYLANLKAAIIENGKFFRSVAEYALQSISFEPGEIVQPNDLDMSKTCSLLTQVYREWSAEAISERNCLNSRLVPFLKTLSPPKADILIPGCGTGRLLVDLSRMGYNCEGNEFSYHMLLVSQYMLNAGLLQNQIIIYPFIHCFSHWKKIEDQLSPIKVPDIEAWSSNKGMGSMSICAGSFVDCYGRNQGTKISSHYTFSRRMQLSRAKAENSKDVVVTNFFIDTGSNILDYLDTIGHVLKPGGIWCNFGPLLYHFENDHGVETTYEVNPYSGFQDKINDYTPLMGLELSSDDIISIATNHLDFELIRRESGILCGYGRYAGPESCAMPGYMCHYWILKSNPTNES
The following text describes a protein:
Function:
Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKLFRFEAEPEKLPPAVLAYLGDAVLELIFRSRFTGDYRMSVIHERVKEHTSKHGQAWMLENIWNLLDEREQEIVKRAMNSKAAKRHGNDPTYRKSTGFEALIGYLFLKREFDRIEELLRVVMDLESLRKKNPGGSAQE
The following text describes a protein:
Function:
Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MSSGAAVPPLQDLSPPNGFPHTIKYKRYLPARGPSGAVMILATIGIMSYGWCMVLDANQENRELLREKAYARIFLAPLLQAETDRDLVRRLDCLKGREAGMMKDRTDWSVLDLKAPVQGIGKGGVRDSAQSEPVYHTKRYVSPTYVYLPQDNKEDTSFSILSPQWWRGSTMSTKNLRYHNRADFTTEYPIGK
The following text describes a protein:
Function:
As the accessory component of the DNA polymerase zeta complex, involved in translesion DNA synthesis (TLS) and various DNA repair mechanisms. Promotes the apurinic/apyrimidinic (AP) endonuclease activity of Rrp1 and is therefore likely to be involved in the base excision repair (BER) pathway responsible for repair of DNA lesions. It does not appear to influence the synthesis activity of the catalytic component Dmpol-zeta.
Sequence:
MQAEIKADIIVEAMEVLVNHILYVRGIYPSHIFKMKRMYNSPIYVSIFPPLNNYLAGVLKSAQELLRRRELQCLELIVYQKENEKLESYKMQLETQRSGLPAEDHLMEFEQNMRSVIYKISQRLNQAPKLPAGSCQFKVHLHTTQEAFIRFSHDSQYQEFPWLQTQKTESQATGRTVYLLPLARVDDLGLKMDVLIVN
The following text describes a protein:
Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
Subcellular Localization:
Secreted.
Sequence:
MIPHRLLPPLLLTLLLAARPGGALAQCPGCGQGVQTGCPGGCAEEEDGGPPTEGCAEAGGCLRREGQQCGVYTPNCAPGLQCQPPEEDQAPLRALLLGRGRCRRARTPSGENPKESKPQAGTTRSQDVNRRDPQKSPGTSTTPSRPNPGGVQDTEMGPCRRHLDSVLQQLQTEVFRGAHTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGQPLAGSPDGDGNAPCPSGSSG
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization. Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis. Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination.
Sequence:
MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
The following text describes a protein:
Function:
Part of the ABC transporter complex FecBCDE involved in citrate-dependent Fe(3+) uptake. Binds both iron-free and iron-loaded citrate although it binds iron-loaded citrate with a higher affinity. Binds different forms of Fe(3+)-citrate as well as citrate complexed with various representative Fe(3+)-mimics (Ga(3+), Al(3+), Sc(3+) and In(3+)) and a representative divalent metal ion (Mg(2+)). Can also bind various tricarboxylates in iron-free and iron-loaded form.
Subcellular Localization:
Periplasm.
Sequence:
MLAFIRFLFAGLLLVISHAFAATVQDEHGTFTLEKTPQRIVVLELSFADALAAVDVIPIGIADDNDAKRILPEVRAHLKPWQSVGTRAQPSLEAIAALKPDLIIADSSRHAGVYIALQQIAPVLLLKSRNETYAENLQSAAIIGEMVGKKREMQARLEQHKERMAQWASQLPKGTRVAFGTSREQQFNLHTQETWTGSVLASLGLNVPAAMAGASMPSIGLEQLLAVNPAWLLVAHYREESIVKRWQQDPLWQMLTAAQKQQVASVDSNTWARMRGIFAAERIAADTVKIFHHQPLTVVK
The following text describes a protein:
Function:
Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.
Sequence:
MSLYAARTCGIAHTSPGLHTATGRKMRRPAKNNATSATPMKAGRQGSSKVRLPIQAPLTPSATSTSGPRQQVDARIAASPPAASAPRPFCCSAIRCPSEYPLSSVTLLPYLCTESSGMDNGSESLTIGAFAKAAGVNVETIRFYQRKGLLLEPDKPYGSIRRYGEGDVTRVRFVKSAQRLGFSLDEIADLLKLEDGTHCDEASSLAEHKLRDIQDKLADLERMEAVLTQLVCACHSRKGNVSCPLIASLQRGEEPRDVGAAAPVTGRDHGRCCDADRACRLRRESGVLCDRAPAPRSARAGAYFSVAPLFGVALSLLIWPEWPSVSFWIATAMMALGIWLHRSVCTRSPVCLCNHGKHEPKHRSWQAARMDGVGVAARVRNCPDDPAGVPTHRPVVVDRRAGRDRGYGCQRLFGPRHRAQGEAWCWDSHFGRNRRGDRQFCGCSPLRFGSDSSVWRGHHDHDALVAVSSPLAAERDDLQITTEHTTMKGKYVLSCGALGGRSPKTGKRVGERHRWSGGGWGKGHCEFCFRTLDQRAVPEGWSVEQHSGFPHVVVLSRPAGGCVSINMKKRIFGPGYGCPHVAMGGAPTRRPDRGERLGHPGRQMATYGPASHVRRFAGCGDGRRLLGKRSENATMANGYTALYGSAFEKVERQLLADGYVCAFACTYGEPAGPVPKDLGRTGKEGGWEMRRKLKDWSSKHGVREYKIVRNTSYVRDLHGDVYELWVKRSEIDVIDAIPNKQWIELADAAIRKVNPSAAEVVQATRGFAVLGREGVLTARLSDGTQWRIDGQDVRQLTADEIAARARLHESFQFLTTAPMSKNSRKVISNPQFIVSPRILAKYRPTSWQTSQNAQHGSFTTKASRSRFRFLCPRGETWSQRISVSGSRCTLQANAGKFMATIPRPRKPRYVVRDSAGRALRETDSKLTAWWVWFKNRRDGAIAHDRLSWIEDERSWLRCGVVTSDGGAGADWMAEATGASLSRAKNGSPDGRCGYGRHLGKPLAWRQRIAETISSGSTRADPSLRTLGGSFPRTAATQRRPHRRQPANRTENYSMKKLAALLACLAPLAATAQVQWAIPGVTVPAPVDRSPPASAVDADGAYIEYKAMLSDGKAATELGRYSSASDCFHRLERASASPEFTSAI
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MPKPYDSYASNTSGDTADADRRWLGAVMHVAFFLLLGGALARFLLRHPGEPRTPWILALSLTLAVLHLLGPVLSGPGPSGPGTPAARRRLVRLGLVVVVWMVLVVLAPSFSWCAVPLFYTGLRTLPTRAALVLVTVLTVLVVAAQFRLAGGFDPNLLLAPPAVAAIAAAVFLHTERQAARQRALIDDLIRTRRELAASERREGTLAERQRLSMEIHDSLAQGLSSQRMLLQAAERVWESDQDKARAHVRGAASVAEHNLAEARRFVHDLAPADLARGGGLEAALRALAARESGDHLTVRVHVDDGTRVPPLPDRVQSALLRIAQGALANVREHAGASTAALSLTLLDDEVVLDVTDDGHGFDPAGPSDAPAGTRGHGLPAMHARLRQLGGTLTVESAPGEGTALSAAIPLDPPRTDPADPAGPQEAPR
The following text describes a protein:
Function:
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity).
Subcellular Localization:
Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
Sequence:
MKPVHERSQECLPPKKRDLPVTSEDMGRTTSCSTNHTPSSDASEWSRGVVVAGQSQAGARVSLGGDGAEAITGLTVDQYGMLYKVAVPPATFSPTGLPSVVNMSPLPPTFNVASSLIQHPGIHYPPLHYAQLPSTSLQFIGSPYSLPYAVPPNFLPSPLLSPSANLATSHLPHFVPYASLLAEGATPPPQAPSPAHSFNKAPSATSPSGQLPHHSSTQPLDLAPGRMPIYYQMSRLPAGYTLHETPPAGASPVLTPQESQSALEAAAANGGQRPRERNLVRRESEALDSPNSKGEGQGLVPVVECVVDGQLFSGSQTPRVEVAAPAHRGTPDTDLEVQRVVGALASQDYRVVAAQRKEEPSPLNLSHHTPDHQGEGRGSARNPAELAEKSQARGFYPQSHQEPVKHRPLPKAMVVANGNLVPTGTDSGLLPVGSEILVASSLDVQARATFPDKEPTPPPITSSHLPSHFMKGAIIQLATGELKRVEDLQTQDFVRSAEVSGGLKIDSSTVVDIQESQWPGFVMLHFVVGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRTTQLFSLPCHRLQVGDVCISISLQSLNSNSVSQASCAPPSQLGPPRERPERTVLGSRELCDSEGKSQPAGEGSRVVEPSQPESGAQACWPAPSFQRYSMQGEEARAALLRPSFIPQEVKLSIEGRSNAGK
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway (By similarity). Regulator of the contractile vacuole network as well as involved in driving vacuole emptying.
Subcellular Localization:
Cytoplasm. Contractile vacuole.
Sequence:
MSSSANSSPATTKFKFTDNLWDGFDLLVKRTDNDLIQSKNILNFFKKKAELEEQHSKKLEKLSLKTMMTIDESTSINAISYNSSWKKIINSSMMESEQHTLLNTSILNKVIQPLQAMIKDMETKRKKILQEGIKLKQDMKEMVDELKKSQFKYDKAGKDLESSRMELREYREQLDHQQQQQPSDSDLNNISKIERRIQRCEQDFSNCDEEYREQIKATNDFQHLYNTEKLPKILNDFEHFVISHSHFSKSYFTNLVSVLIELPSAYQQNYEFVKKSVEMIDITNDVQEFIRKNLMKKQLAQPFQYEPYIEGKLTKKTISLTWNNKILSQFSRSSNNNTATANNTSSGNLNPYLNGGIGGTKKDEPILPTASFKVSLDELMNRQKDNHPTLEVPYVLQVLSTRIAQMKGHVTEGIFRVPGIISTIKETRLRIDKADFNLSNIDDVRTPAALLKQWLRDIPTALIPDSLYQQCIDTPTNAIAIVKTIPIINQRVLCYLINFLQIFTKFEFVAHSKMGTSNLAMVFAPCILRCTSTDANVMLNNVPNERLFVETLIKQIPPPLNTNEFLNLPISMSDAINDSEDIEELNDLDQLSNDDNNNSNTNTSNISIGSGSNSNIVVNYSNNSPNIESSTLPSQSVVTTIETLPPLNDDHNSGSGNESNSSSSNSTTTPTGSPTTASKPRGPRTQTLGWVRIKPAPKPSAEPTITLSSSIAAGTTTTTTTATGITTTTTTTAGPEKTIISPVIIKPAAATPTTTTPTTTPTTTTSPTTATIPAVSTSTIKTSSPDRTTPLTSSPPLASTKSTDELMKKLDQFTQETTPSIRIATTTTPTTITTPTTTATTTTITTDKTTPVTSSPPTASNISSEDLMKKLDQFINF
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPCECSKTGSCNCGGSCKCSNCACTSCKKASCCDCCPSGCSKCASGCVCKGKTCDTSCCQ
The following text describes a protein:
Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MDLIPACDRTMSSSCLVAELVSIAPNTTVGLPSGIPMATRSLILLVCLLLMVWSHSEKKTIPGPSFCLGLGPLMSYLRFIWTGIGTASNYYNNKYGDIVRVWINGEETLILSRASAVHHVLKNRKYTSRFGSKQGLSCIGMNEKGIIFNNNVALWKKIRTYFTKALTGPNLQQTVEVCVTSTQTHLDNLSSLSYVDVLGFLRCTVVDISNRLFLGVPVDEKELLQKIHKYFDTWQTVLIKPDIYFKFSWIHQRHKTAAQELQDAIESLVERKRKEMEQAEKLDNINFTAELIFAQGHGELSAENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPHVELQLLQEIDTIVGDSQLQNQDLQKLQVLESFINECLRFHPVVDFTMRRALFDDIIDGHRVQKGTNIILNTGRMHRTEFFHKANEFSLENFQKNTPRRYFQPFGSGPRACVGRHIAMVMMKSILVTLLSQYSVCPHEGLTLDCLPQTNNLSQQPVEHHQEADHLSMTFLPRQRGIWESPSPF