lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cardiomyocyte differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MLLESSRSTFCAIISQLTEETQPLFETTIKSRSVSEDSDAKFTCIVTGYPQPEVTWYKDNEEMDRYCGLPKYQIFHHGNRHTLQLYKCREEDAGIYQASARNTKGIVSCSGVLEVGTMTEFKIHQKWFAKIKRKAEEKLREIEQSKKRGKENVEVESLQGMSPDRLQRKRRLARDLNLRSGASLWEKEDAAKVHVTDSKSRLREDVADSKEQSVNAMTGLPSKLITPLKAEVTTNGDASLESVEENGNGFLAYIYETVEDLVSKPLAKDSAAKKKKKVEDAPAAKQEVLKREESGRDRVKPSTNPSNIKHPVSGPNTDSSQQADKLEELRKETPVSQETRGTGKRTNPRLRFQDTSKPPAPSADHAQTSREQPASRAQAEGHSHALEGRETQGLSNQEVKSQGTKEPLPKKLSPPELGEDTPHEKSTHQAAVKDEKSKEEGVGPSGSKPCAEAGGSSVAELSPEKAGTPLELQETETPAPASVCVAEEKLIPTAAVGTLVVQEAPPAACSSQEMKTAAAEAPSGIQLLPSVSKDTETKKADGAAPQEMFPTSTSGKADAKPVSVVPQRKEGGMQMATAPSQQPAAPLGIFERGAEVQPQAPLILPSPERPQEMTLEEKMQHKNLVSSLKNYLLLLLQLSDSSKDATKEDAEPRGEEPSAAEEAPLPAIGIAGLSPRTSRRVFEKVQNNQLFQTAENLPLTPRTSRRITGMINEEFITSKEMLACRPVPPKRRTKMAPEAEGPLQLSVPSIVVGNVPAAAVGQPPHSVPNLPPVISEKESPADPLAVLPCATPEELASGARRKIYLPKTKQAGEEEEVSPESQGHSRSPTVSPRQSRKSAALLQTPALAPSPPTEKRSPTLTKKMATLEVPKLYEEPTGDSSRDHEVPEDAKPEEQPAESKKASNPFKAPQVIRKIRAEQFSDASGNLKLWCQFFNILSDSKLMWYKDELPVAEAQRSAGDEGQAALAIVQASQKDCGVYRCVISNEYGMDSTDFLLSPEVLSGFILREEIEVGEEIEMTPMVFAKGLADAGYWGDKFFGRVMSEDMELGAGFLRKACRARAIYGLEPVFESGCTCIIKVHNFIVFGTKNENSLIEKNYDITIQECKIQNSSREYCKIFAAEARAVPGFGAVPEIVPLYLIYRPANNVPYATMEEDLGGPCEQYCVTERDGSLVARGTSEIVLKCCTFQHWVYQWTNGNILVTDMEGVGWKMTNVRIATNFKGYQGLKESCFPSLLEQFAATHQCNHYCDMLGLKTLEPVKPKGSKSPSMGRKSAQSSPQLQKKGTTSPQGTRKTTVSPRSARRMAEAAEAQAQAGGTPAFGCCPSS
The following text describes a protein:
Function:
RNA binding protein that is required for normal cell division and cytokinesis during embryonic development. Functions with RNA-binding protein atx-2 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Furthermore, negatively regulates the levels of the protein kinase zyg-1 at the centrosome. Also involved in ensuring centrosome attachment to the nuclear envelope.
Subcellular Localization:
Cytoplasm. Note=Co-localizes with atx-2 in the cytoplasm; [Isoform f]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Chromosome. Note=Co-localizes with sas-4 at centrioles. Localizes to nucleoli during interphase and to the surface of chromosomes during meiosis and mitosis. Localizes in puncta adjacent to the male pronucleus at the centrosome during meiosis. Localization at the centrosome peaks at prometaphase and metaphase, but then decreases and expression is at its most minimal during interphase.
Domain:
The C-terminal part is necessary for interaction with atx-2; The SUZ domain is necessary for RNA binding.
Sequence:
MSKENVVADSWDDADADPVKELMDKVEKVKLLQRKEEKKEAFFEKVKAEESSGVVSKLQTEEGLGPSAEEPKRVFLRRPKDGFAASENVIEASPPTSADTEEQPVTNVRSRSHHKLNQKEKQPAPTYEERQAAYQAARNRILGTEYKPDNQEIKEIKFIDRSKSPETLKMTQQNMVEHYGEELSRELMEQPAEIVPPERQYTPDFTQPPPSVSESGGVYNGPPGFQQKQPNFQPTLQQQSLHQQQYLDNQYMMQMNVQIPIQYHNQTQHQFVPHEASAISTTSQNSNGDGQNDQAIYYYQAPTQQPMNYIPYNLPNMAYPPPNFQPQGQLHHQMNAGQLHQIQQQQQQCQQIQHQPPQQHQQVINGQVMNQQNQRNQVNSYPQQNGAGRGQNRQPMMYQMPCNSGPTAKPPPLMNQMQNRCMTNNGQNYQNRNMQQQGQQRSYSSQPQNGQFYQNGNSNQNNPNNGRKQQHQPQQQQNKSGKFGQNRNDMQKNNYQPNLQQPPMSQNPIPFGCPPRNVNAIREQHANNGSPNTGAGILGPHPMMSASQWPALQQNRPQ
The following text describes a protein:
Function:
Plays a role in maintaining adipose tissue function through the regulation of ceramide levels. Mediates the stability of ceramide synthetases, CERS2 and CERS5, and their activities (Probable).
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAFLAGPRLLDWASSPPHLQFNKFVLTGYRPASSGSGCLRSLFYLHNELGNIYTHGLALLGFLVLVPMTMPWGQLGKDGWLGGTHCVACLAPPAGSVLYHLFMCHQGGSAVYARLLALDMCGVCLVNTLGALPIIHCTLACRPWLRPAALVGYTVLSGVAGWRALTAPSTSARLRAFGWQAAARLLVFGARGVGLGSGAPGSLPCYLRMDALALLGGLVNVARLPERWGPGRFDYWGNSHQIMHLLSVGSILQLHAGVVPDLLWAAHHACPRD
The following text describes a protein:
Function:
Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.
Sequence:
MGPSGLLVALALHLAVCSRPHRDYCVLGAGPAGLQMAALLHRAGRDYEVFERESAPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSDDPHLLFRHYSQAYFPDASDMVRYLGDFAQRLGLRVLYNTNITHVTLDKDPQAWNGHYFILRDQKGQVYQCSVLLVATGLAVPKLVDFPGSEYVEGYESVSVDPEDFVGQNVLILGHGNSAFETAENILGVTNFVHMLSRSRVRLSWATHYVGDVRAINNGLLDTYQLKSLDGLLESDLEYLALVKDSKGKFHITLKFLLENSSNQSADSIPLPQDDNDNFAMRVAYDRVIRCLGWKFDFSIFNQSLRLSSGTEFSKKYPLIKASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEHRHHGITWPSTQYPITQLTSSIIRRVNEASGLYQMFSVLADIILLKENATAFEYLEEFPIQMLAQLEMLTGRTARHGIFVINMEYGKNFSGPEKDVFYYDRSVAHIEDAWMSNFLHPVIYYYRHLPTEQDMRFRPAQWPLPRPVAIHHIVEDFLTDWTAPVGHILPLRRFLENCLDTDLRSFYAESCFLFTLTRQKLPPFCQQGYLRMQGLSSTKSLRQHGVESRLLQDYTAMENSSRWLDDHSSAPGPLTQFLDSNREEL
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin and transcription pause-release checkpoint.
Domain:
The inhibitory loop acts as a regulator of protein phosphatase 2A (PP2A) activity: Asp-629 and Glu-630 residues mimic phosphoserine and phosphothreonine residues and bind to the PP2A catalytic subunit PPP2CA active site to block substrate-binding.
Sequence:
MPILLFLLDTSASMNQRSHLGTTYLDIAKGAVETFMKLRSRDPASRGDRYMLVTVEEPPYGIKAGWKENHATFMNELKNLQAVGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPSIIIVITDGSKLTTANGVQDELHLPLYSPLPGSELTKEPFRWDQRLFALVLRLPGASLVEQEQPPAVQFDESPITAMCDVTGGRSYSVTSQRILNQCLESLVQKVQSGVVIHFEKSGPDPPILEDGLTDPVRSVGSQPWHNCHKLIYVRPNPKTGVPLGHWPIPESFWPDQNSPTLPPRTSHPVVKFSCTDSEPMIIDKLPFDKYELEPSPLTQFILERKSPHSCWPVFVANSAKYSELGHPFGYLKASTALNCVNLFVLPYNYPVFLPLLDDLFKIHKNKPSLKWRQLFENYLKTMPPYYIGPLKKALRMMGAPNLMPDSMEYGLSYSVVSYLKKLSQQAKVESDRVIGSIGKKFPQETGIKVRSGSNALSLALRKDFKQLLQEITGEVPQRPMDLNMKEFAGFQIALLNKDIKPQTFRNAYDVPRTNLLDHLTRMRVNLLRSTRQFLKGQDEDQAHSIPIVQMGNYQEFLKHIPSPLRELDYDQPRRLHTFGNPFKLDKKGMMIDEADEFVSGNQNKHKRTGEPNMQGVPKRRRCMSPLLRSRPQSPAVINNHIGGKDPPISVNQVSPDLPKPVAVHKNTDLSNNATVNEATENHVADHFCDDLLITKSEPFGTLSSAALEATEGYAAEKDSNFRPNDISDVFLENTKETGDNESCLPNNNAAFTHRKRRLQQCRSYEEANIELKAQILKEIRKPGRKYGIIFTLLKDVQGDLQTRLLFLQNVIQEAARFKKRNLIEQLEGFLEEIHRRASQVNHLSSC
The following text describes a protein:
Function:
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Subcellular Localization:
Plastid, amyloplast. Plastid, chloroplast.
Sequence:
MATSSYCATANGAELFTHYASNSRLIGFNSRNRSSKLFLTRTSDFRGVKRCFHVKSVSSEPKQKVQDPVTEEGAESVLSSFAPDAASVASSIRYHAEFTPLFSPERFELPKAFFATAQSVLDSLLINWNATYDFYEKMNLKQAYYLSMEFLQGRALLNAIGNLELTGSYAEALKNLGHNLENVVSQEPDAALGNGGLGRLASCFLDSLATLNYPAWGYGLRYKYGLFKQQITKDGQEELAEDWLELGSPWEIVRNDVSYPIKFYGKVTTGSDGKKYWIGGEDIKAVAYDVPIPGYKTKTTINLRLWSTQVPSADFDLSAFNSGEHTKACEAQANAEKICYILYPGDGSVEGKILRLKQQYTLCSASLQDIIARFERRSGDRIKWEEFPEKVAVQMNDTHPTLCIPELMRILIDLKGLSWKEAWNITKRTVAYTNHTVLPEALEKWSYELMEKLLPRHVEIIQMIDEELVHEIVSKYGSLELDKLEEKLAAMRILENFDIPSSVADLFTKPERLVDADTETVEVSDKVEVVTNDEEDKNEEDDTGKKTSLKPEPGAKDIDKKTTVVSEPAVIPPKMVRMANLCVVGGHAVNGVAEIHSEIVKEEVFNEFYELWPEKFQNKTNGVTPRRWIRFCNPPLSSIITKWTGTEDWVLNTEKLAELQQFVDNEDLQIEWREAKRSNKIKAVSFLKEKTGYSVIPDAMFDIQVKRIHEYKRQLLNIFGIVYRYKKMKEMTAAERKAKYVPRVCIFGGKAFATYVQAKRIVKFITDVGATINHDPEIGDLLKVIFVPDYNVSVAELLIPASDLSEHISTAGMEASGTSNMKFAMNGCIQIGTLDGANVEIREEVGEENFFLFGAQAHEIAGLRKERAEGKFVPDERFEEVKEFVRSGAFGSYNYDDLIGSLEGNEGFGRADYFLVGKDFPSYIECQEKVDEAYRDQKRWTKMSILNTAGSSKFSSDRTIREYAKDIWNIEPVKLP
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MKRIATPSLTSRLLVAARSGVSPATAAIRSRSAISVRSQSTAALAQHDASHDLNNDRFPPLEPLPPAAESLPSPLPERALTSAKLAALHARLNLSPKIPLQTLARTLVDASADENPQFNNANLAFVGQTLINYHIAEWLLCKYPRLPQGILFSAMKAYAGPKPLLQIARSWGVDTAAVPGGEVDPGLLQFDALKPGVAITNFGYKRTELAYLEKFKWRRGMASRVVLDDDFGDVVRSDPKVAADLEKAMEEQDQDKTPDEEEAEMVANEQDQDVSYDRYGNPDTRAAAERAHAYFVRAVVGAIYAHCGREAAKAFVKAHIMSRTLDIAKLFEFKYPTRELAALCAREDFEPPVARLLSETGRQSRTPVFVVGIYSGSDKLGEGAASSLDHARFKAAMNALKAWYLYSPGENPRVPSDMLEEGAKPWTPAYIDMGEVISR
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
MTNSATQGLDALQTWKLEDAKARFSELVRLAQGENPQLVTVRGKDAVVVLAADQFAKLLPLMAQPNIHEFLSQSPLNRLDFEHSSVQSPVRELEL
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKPIVAPPMSTVIDSSGASKDYSPSQLALKLHTLPHLDLTFQRVNSSFNPDLYRYREAILFWSIVPLVWMFLTMLVVVMYFCYHCCQSDVQKAGVCLKWSIAVLALLSCGAVGAGFYGNEETHKGLQHFIDAAKGIQFTTSQTRAQIKWMEVNLNHSVISLANDLRSNIPRSHSLRTEINQHLDRSVRHVTSIISSVLDIGFKVKRIDSTIELVHYAGRYGFYRWLAMVLLFSWMMVLFVILLFAVGKGSKYLMLAFGILSIVSLILCWLAAGLHLGVIIGTADFCIAPLAYLEQMTEEKSDREIIKYYMKCDHQFVDNPFKNVGYETFPRFAYILSKIFIYTFIRHLLASQTIPSTYDNAREANISLAKVHMSLLKILPNSKEKEVVRDKMKKIFKGMDSTFQLLMHINALVECTNLHKDYLDGVSGICFNGLQFDNKINNRLNVNYGIFRDGMVFLLVSIGLTGIFFTGVVLLTSGSWRSFTSGFGEKFKKSFNDQK
The following text describes a protein:
Function:
Transcriptional activator. Activates ectoderm, in addition to inhibiting mesoderm and endoderm formation; required at the blastula stage for normal formation of both the central nervous system and epidermis, the two early derivatives of the ectoderm. In addition, also required to maintain the regional identity of the animal cells of the blastula, the cells that are precursors of ectodermal structures. Also plays a role in differential adhesion, which limits cell mixing as primary germ layers become specified.
Subcellular Localization:
Nucleus.
Sequence:
MSAFDPQAHSPPRCGPQFPSIGQEPPEMNIYCESFLHPQTMPSPQRPSNFETGDYSTTANPYLWLNGPSITPPPYLPGSNSSHFMPQAYGMQRQLLPNMHGLGSSELGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSPNGQLSSDKPEGSPLSESPTNGEHQDMLGNSSPGTDDSPEKRSPPPSITPCLNNFLSSMTAYVNSATPISRSVPLGLSNETSDKMGQNMVGFNSYTPLSNMPSHGGSDWSSTVSSNPFGYSSSVFNQFTPHFYNSMSTNNTLYNREGTEV
The following text describes a protein:
Function:
Represses an operon that comprises itself, XF_0764, XF_0765, XF_0766 and blh. Binds to a palindromic AT-rich sequence spanning the -10 region of the blh promoter and blocks transcription of the operon.
Sequence:
MVNEMRDDTRPHMTREDMEKRANEVANLLKTLSHPVRLMLVCTLVEGEFSVGELEQQIGIGQPTLSQQLGVLRESGIVETRRNIKQIFYRLTEAKAAQLVNALYTIFCAQEKQA
The following text describes a protein:
Function:
As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MNPQPEISLSTGIFQSNNELPEGTAYPEAIVQVLNIKKVPNGQGQPGMERYRLMISDGVNYIQSMIASQLNELVSSGSITKFGIIKLQKYICNTVSSKRILIILALENLTPFNDTIQRVGNPVSLDGNTVTDPNAATHAPAVGSASTFGQQHAPALPTSSFSRQQGQQPMALPSNYNQQAGRSALSGSGSSNMPYGGGASTVNNGDTAGPYFAIKTLNPYQNKWTIKGVIINKGSVRTWNKAGREGRLFNFTISDDSGDIRCTGFNEAVDMFYESIQEGQAYVISKAMIKVSNPAFNKGGHDYEMTIDPHTSITVCNDPKSIPQIKYNALTLDRLLEVEKDAVIDILAVVKECFPVSEITTKANNKLKKRDLNIVDESGWLVRLTLWGSQAETFEHSDNPVIGIKNARVGDFGGRTLSVAMSSTLTLNPTMQDAFRLRGWFDAKASSIDFHTYSKSSSGVTSGNSTHSNLKTIQQIQDANLGNGEKPDYVSLRAFISFAKRENLWYPACPNEACRNKKVVEIGSEWRCEKCDSNYPHPVYRYITSFSVSDYTGQTWLQAFNETVEKVLGKTANEMQKLVDTDKDEFDRIIEQAIYQEYVFDVRAKAEMYQDAKKTRLTIVEAKEVDYAAASREMLATISSVLG
The following text describes a protein:
Function:
Specific for inorganic phosphate transport across the thylakoid membrane in a sodium dependent manner. Binds glutamate but cannot transport it. May act as an ascorbate transporter at the thylakoid membrane (Probable).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site; MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MNARALLCSSNIHSLYTSNRPPEKTSSSRSLRNLKPSPKSLRVWIYPRNRSSVFRVLVRSSDKSESSNSYYVEGDKVSGNNDVVSDSPSSIVLPWWEEFPKRWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAESSPLEDPTLLPEERKLIADNCASKEPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIWNLFSTGEKIID
The following text describes a protein:
Function:
Cofactor for serine ADP-ribosylation that confers serine specificity on Parp. Switches the amino acid specificity of Parp from aspartate or glutamate to serine residues. Acts by completing the active site of Parp: forms a composite active site composed of residues from HPF1/CG1218 and Parp.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MPKEDCKYWDKCYQQNPAHLSKYNHPKKQQEHEVDGAEGKKVAPKRSASSQSGEQKKEEQTEPVNKDKSNTSASSTEMVNKDTAKGSYEAETEELHKEAMSNISGKNYMEILEKRIRLSVQKEYDNLCESNEFIRHKFLVEMPPDFYEFWKFVGSLKIDPAKPKDAGLEHLDKVFQLQLVGPFEFLAGKFHGAKLGEPGDYLRHWRFYYDPPEFQTIFVRRGTGIHYGYWRDVPQDKENLLIARNDSAKGCQFQFVAGNAFDAFLYYLEHDFAATPFSCGQLAGTKKAVAKYLSDNSLELAQLDRLQRERNKRVVAKTFHRAGIVVPFDQKTEVGYRPLAVSDSELKKMLAMLERKDVDNGAAKQAVLEKLQPVANAANIAVDESDFGSALELGIDMFCSGHKELHMLASSLLVPAYSMLSRPQFIAIAKAHMEQRSREDNLSIFDVLK
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Sequence:
MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFADSGQDRDPHRLNSHLKLGFEDVIAEPVTTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGILFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVIIAPLCTSVGRSFSSVSLQLSQD
The following text describes a protein:
Function:
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSTTINRNEKTKQVVNKTKEIKTESSQQQQQKPPISKLMGIILATRPWSLTISVTSVLVGSALAFREIREFDSIMLSIILVGAVSLQALGNVVNSFYDCKNGNDTKEKSADRTMFDFGLTEGNIINLIWYLLIQCAICLGLMIFRMDNIKCIVENILPLGAFGFILNISYTAAPIGLKYIGLGDLTIFLCFGPILVQSAFISQTHYHDSLAYFYSIPLALTIVAVLHVNNTRDIKADTEAGSITLASKLGFKNCYYIYAGLYLFAYIYLFKLSLDIDKYILNLPLILIPKIISLINQFKNKKLEDLTEKTGQLSFFFGGLNAIGVLLSMQ
The following text describes a protein:
Function:
The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. Once the capsid is packaged with the DNA, the terminase cleaves the viral genome concatemer and is substituted by the tail.
Domain:
The ATPase region is in the N-terminus, whereas the nuclease region is in the C-terminus.
Sequence:
MDTQERLRNLVRELAERQKYFRMNQYTPYGWQEKFIAASSNCAQLLAMTGNRCGKTYTGAFIMACHLTGRYPEWWTGRKFDKPVNCWAAGISTDTTRDILQSELLGDWKNPEAFGTGMIPKEDIVKTERREGKPGCVQAVMVRHVSGGLSSLIFKSYEMSQDKFMGTAIDVIWLDEECPKDIYTQCVTRTATTGGIVYLTFTPEHGLTEIVKDFLQDLKPGQFLIHASWEDAPHLSPEVKEQLLSVYSPAERRMRAEGIPMLGSGVVFPILEEKFVCEPFDIPDHFHRIIGIDLGFDHPNAIACVAWDAEKDKYYLYDERSESGETLGMHADAIYLKGGHQIPVVVPHDAFKHDGATSGRRFVDLLKDDHNLNVVYEPFSNPPGPDGKHGGNSVEFGVNWMLTRMENGDLKVFNTCTNFLKEMKMYHRKDGKIVDRNDDMISATRYALLMASRHARPGAVRNSGYYRSDTARLIPDWFGSIV
The following text describes a protein:
Function:
Putative transcription factor that may be involved in the ethylene response pathway.
Subcellular Localization:
Nucleus.
Sequence:
MVEVEELEPLSPMDDEEEEISYDDLKRRMWKDRNLMEKKLKQQKRHSNDVVSFTTHRAEASRRKKMARSQDSVLKYMMKIMEVCKAKGFVYGIVPEKGKPITGSSDSLRRWWKENVQFDQNAPDAITDYLALAAAAAAAELIDKSSSSSSLLHMLQELQDTTLGSLLSALMQHCMPPQRRFPLEKGIAPPWWPTGTELWWGEQGAAHEHGAPPYRKPHDLRKSWKVSVLAAVIKHMSPNLGRVRRLARQSKSLQDKMMAKETDTWSRVLNQEEALLNIKDLKISEDQDDQESSGSKRKSESMEPSKSVYTCQNSSCPKSDVSFGFGDKNSRTGHEIQCLYGSNQEPSQSGEYTSSLLETVPSIVTNSTSEDDYYNVSSRALDKRDDDDHSINGNWMEYFWLEKMQQEFHCSRRFEDDEGTGTDFDQLTESDRSDNVNLNQLTKSDRSDNVNRSAFSVWDMGCEDKDIYMFD
The following text describes a protein:
Function:
Required for mobilization of iron from the bacterioferritin (BFR) complex (By similarity).
Sequence:
MYVCLCNGISDKKIRQAVRQFSPHSFQQLKKFIPVGNQCGKCVRAAREVMEDELMQLPEFKESA
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MEPPLGALLVLCSLLLLAYPSSSAAHGHGHYHEHYDNATVYNVSVAAAAAAGTQGLGAWADALEFLYYHNAVRMARWEPPLAWSPRLESYARWWAAQRRADGCALRHSFPDGQFALGENIFWGSGAAASWRPGDAVKEWAAEGVDYSYAANACAPGRECAHYTQIVWRRTALLGCARVVCGDDGGGVFMTCNYYPPGNVVGERPY
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPVKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MIFTNHRTALPSNQNQPAPGQRSWFLPRHRGDASHSASRHAQAPGSCGPATRSIAAAATGSTPALSVCGRAPLRYSSPAHGSIIRRGGDQSHRAGADMFGFPTATLLDCHGRYAQNVAFFTYWCILHDFPLVLPDVMTEAHKYDSSEATGSSSWDFQSSFRREKLEQKSPDSKALQEDSPGVRQKVYDCQECGKSFRQKGSLTLHERIHTGQKPFECTQCGKSFRAKGNLVTHQRIHTGEKPYQCKECGKSFSQRGSLAVHERLHTGQKPYECAICQRSFRNQSNLAVHRRVHSGEKPYRCDQCGKAFSQKGSLIVHIRVHTGLKPYACSHCRKSFHTRGNCILHGKIHTGETPYLCGQCGKSFTQRGSLAVHQRSCSQRLTL
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MTFLAILFVIAVLLLLAQLPVIGFYIRAVYFGMCLIIGGFLGGLASIPFGKSPNNHFRMFKIFQAMTWPMGVRFELRNSEILHDKKPYIIIANHQSALDVLGMSFAWPVDCVVMLKSSLKYLPGFNLCAYLCDSVYINRFSKEKALKTVDTTLHEIVTKKRKVWIYPEGTRNAEPELLPFKKGAFILAKQAKIPIVPCVFSSHKFFYSHAEKRLTSGNCIIDILPEVDSSKFDSIDDLSAHCRKIMQAHREKLDAEAANLNI
The following text describes a protein:
Function:
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.
Sequence:
MSNSDKASQQLQDHAASQNSDILTNSGGDPVESLTNLQTVGPRGPALFQNITYLDNQAHFNRERIPERVAHAKGAGAFGYFEVTNDITKYCKAKTFTTKISYSPIDLKLNFCFAAGEKGSADTVRDAHGFAVRFYTVEGNWDLVGINSPVFLVRDAILTNQGVKNLSAQQAAALTGTDPDYAIRDLYNAIAAGNFPSWNMFIQVMTFEQAEAFQFNPFDVTKIWPHAEYPLIPVGKLVLNRNPTNYFAEVEQLGFSPANLVPGILPSPDKVLQGRLFAYSDTQRHRLGANATQIPVNCPYNTTVSNYQRDGPMTVINQG
The following text describes a protein:
Function:
Calcium-regulated protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Can promote the assembly of monomers into filaments (nucleation) as well as sever existing filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MMKKLSFVVVLFGLFCNVAFSAVGQVSIGDSNIAGLGTDLERSVKLTSARTERAWAEAGKAVGLLIWRIEKFKVVAWPKVKYGQFHEGDSYIILNTRYKSSTSRDYEYDLHFWIGKDSTQDEYGAAAYKTVELDTYLGDKPKQYREVQGEESSLFKSHFNNNIRYLPGGMASGFRKVEPVVYLPRLIKFSGSRQNVKTEEIPLKGATIDGGNCYILDLGLTVYQLNGAGSNKDNRYKALEFLQKIKSERGRVKTETFEGSEMNPDHIFMKTLKRESGINFEHGAEYTYSPTLFQSKTVTNRADVVKAKEGNIRRSDLKSDDAFVLDTGKDLFVWYGSTSTKDERDKALSFAHNHLRVSKHSMIPMNVIDEKQLTSPSYIKPAYFDISLSA
The following text describes a protein:
Function:
Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell surface. Endosome, multivesicular body. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Melanosome. Membrane; Multi-pass membrane protein. Secreted, extracellular exosome.
Sequence:
MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRSGYEVM