lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the formation of a Delta12 double bond, acting on monounsaturated fatty acyl substrates like palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA) and oleoyl-CoA ((9Z)-octadecenoyl-CoA) with higher desaturation activity on (9Z)-octadecenoyl-CoA than (9Z)-hexadecenoyl-CoA. Requires preexisting cis double bond at the Delta9 position of fatty acyls to be able to insert the Delta12 double bond. Delta12-desaturation of (9Z)-octadecenoyl-CoA in insects produces (9Z,12Z)-octadecadienoyl-CoA (linoleoyl-CoA) which may be used to supply precursors of crucial mediators of immunity and reproduction and other essential functions.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MSAQTITTTETTQNAQKPQQYHWRMVWRNIILYIIMHLTGFYGLYLAMFYAQWKTVFYSWFLLVIALQGVTAGSHRLWAHKAYKARLPLRMLLCIFQTLSLQNHIYDWATYHRVHHKFVDTNADPHNSRRGFFFSHMGWLFIEPHKDVEDKYKSIDFSDLHADSVVMIQKKYYHTFFAPVIGFYLPAAIPWYFWGENFWTAFFVATMLRYCACTNITFLVNSWAHIYGSRPYDKNIYPTESATIAVLTGGEGWHNYHHTFPWDYKTGEFGKYRSNLTTGFLDFMAAIGWAYDLKTVSEEMIMKRVLRTGDGTRKFDKIDKILNVDDDHHHEDMLWGWGDSDMAKEEMNYVKIHNRKED
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLLRYHSKRSLFLLVIFCILNRERCQSIPLENKNVNMNGEIIVDLGLILDMETWIGYSIYSCINLAISDFYSINHNYTTRIVLQTKDSEGDPLKALSAIRYLLKNKNVQAIIGPETYLQSKLLALIADKAKVPIFSFASPSSMEYPYLFQIKEDESTMAKSLAALVKSYKWRNVIFIHEDTEVGREILPNFLASFQDKNIGIYYKSAISASATHDQINVELSKLKNFSTSIIIVHMSPSLASSVFLIAKRLGMIREGYVWILTEKTVDIFRSTKFEVIESLQGALGFRSYVPASSRLYSLTTRWYTSFFKMYPSYVRKELPMLAIWAYDTVWALAESIEKVGVPHNGSLLLNEILKTRIKGISGDQFQFSKGKVVTNGYEIVNAIDHGYKRVGYWTESEGIKKAHPLIISGNRYSSMGLEHVIWPGGAETAPKGGVLATIPGKRLKIGVLKITNFKYFMDIDHDVEKNVTTATGFSFDVFNHCISALPYEVPYELIPFENVTYDHLVQKVYNQEIDAIVGDSTILASRSEYVDFTATYSDLGVGTLVRMKKKDMWIFLKPLGIDLWLTAIAFVIFTVFVVWAIEYMNQESENSSPLRLGTIFWLVLLTIFSAQREKKLSSNSSSLVMYTWLIVVLILITSYTATLASMLTVEQFQLASNEGIFGFNGNSFMRRVTVSNLNFEDHKLRPYYSYQDYAHALSKGGKHGGADAIIDEIPYIKMFLSKYSDDYAMVSSQPITSGFGFISPKGSRLGAELSREIAKMRLDGILEDMEKKWFRNRIPYSSQDSSIMPKSLNLGRLGGLFIVSGIFSALTLVISAVYLLCAKMEVHNIISLIDKHNLMASIRYLFYRNVIIHN
The following text describes a protein:
Function:
Catalyzes the production of nitric oxide.
Miscellaneous:
MISCELLANEOUS: This protein is similar to the oxygenase domain of eukaryotic nitric oxide synthases but lacks the reductase domain which, in eukaryotes, is responsible for transfer of electrons to the ferric heme during nitric oxide synthesis.
Sequence:
MLFKEAQAFIENMYKECHYETQIINKRLHDIELEIKETGTYTHTEEELIYGAKMAWRNSNRCIGRLFWDSLNVIDARDVTDEASFLSSITYHITQATNEGKLKPYITIYAPKDGPKIFNNQLIRYAGYDNCGDPAEKEVTRLANHLGWKGKGTNFDVLPLIYQLPNESVKFYEYPTSLIKEVPIEHNHYPKLRKLNLKWYAVPIISNMDLKIGGIVYPTAPFNGWYMVTEIGVRNFIDDYRYNLLEKVADAFEFDTLKNNSFNKDRALVELNYAVYHSFKKEGVSIVDHLTAAKQFELFERNEAQQGRQVTGKWSWLAPPLSPTLTSNYHHGYDNTVKDPNFFYKKKESNANQCPFHH
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MVLLAALFLSLVLLVSLANVLLLRVPPKKLPALLRTLFAQPPPPAAPGKVEEAVAGSDANGDGRIDLDEFCGLLESMSAVGSAVGSSSSDRSLGDGECGGEEAELKEAFDVFDRNGDGVITVEELEGVLSSLGMSEGKRAKACEEMIRKVDVDGDGMVNFDEFKRMMRGGQALLVSA
The following text describes a protein:
Function:
Cysteine protease inhibitor which inhibits members of the peptidase C1 family. Does not inhibit asparaginyl endopeptidase. May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation.
Sequence:
MRFILLIALVFAVLDGINCQIAGGLSDVNASEYTGAAWNSVPEINSKNNGQNYMVPIKVVKAQVQVVAGTNTVLEVLVGESTCPRQGSVQASQVTAANCPLKSGGKRELYKVSIWEKPWENFKQTKAEKIRGVKPDEKI
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MTLLAIKMTRWLTQVAVWRFVGFVSTIVGLVCYGLSSSFNYLFGEWSLLKIFLYSGFSLFICLGNLFAKVCRPSTSTSLRFKAHSSFLVLTITSVYSYFADKAMNGKPDVYSLISCVSFAIMSFSLSRQTQCGFEVDLFYFFLGCLIVLLLKIKFALAVVGVGFSYSLIILRSSLDTALHHNLGAQVDQLASTTDTSAVVLFVDQLGRTDIDVAAVQDIVVEGQRDNAQRDNASMMQQLMACIEVLRQGNSNLTNMLLEHTKEYFDDKSELAGVDHNFVIDALPSGKINDLEETIKLMVDDGLEKECCDVYCNWRRESLEQCIINLLRLQGINIEEKLEQREFQYYILRWIKAVNVAHRILFPSERRLCDCIFSRFSSVAALCFNEVCRGALIQLLNFAEAVASGSPSEWRLSKILDMFETLRDLIPEFQSLFPESMVKEVMKVHDKLGEASRVIFMNMENVIFHIPETKVIAPADGRVHLMTKHVIRYLVFTSRAQKILEQILEQYPKFANEVAKSNSVSDQIDQVIKRLETELVTVSKNYDKPALRYFFLMNNWRCVELEAIKLRLNLGCFHKDTTKVQQNLELYQSSSWNMVLNFLKLENNELVEPNANAESLKGSLNLFNMHFKDICSTQSRWLAFDKQLSEKIIMSLQHILLPAYGNFIEKLQDVLGIHASEYIKYGLFDIKDQLNHLFLGSMPMNQYLKDKEKLLKLA
The following text describes a protein:
Function:
Possible ligand of InR/insulin-like receptor.
Subcellular Localization:
Secreted.
Sequence:
MVLKVPTSKVLLVLATLFAVAAMISSWMPQVAASPLAPTEYEQRRMMCSTGLSDVIQKICVSGTVALGDVFPNSFGKRRKRDLQNVTDLCCKSGGCTYRELLQYCKG
The following text describes a protein:
Function:
Probable transcription factor that may function in the maintenance of the proper function of the central cell in pollen tube attraction.
Subcellular Localization:
Nucleus.
Sequence:
MRSPRPSSCSKCSSSPSSTHSLAATSLKSRLLTIFKKAQELTTLCDIEACVIHYGPDGELKTWPEDRDKVKDLALRYIQLDEAKRRKKSVNLYEFLNKMKEKKTMINKKAKRNVEELKYPISDHYSPHQINQLIHSLELSYSTLQERRRFLAAKANLEDRQHSLNPSHFTQESMLKNQELCVNDKNSNNFQHLCVSDYSAVQESALRYHSMLYDQNMMCMGNINNVQHPWLSNAHPPELQEPNQLMQRELNYGFDQNMCMSDTTNSFSVVDPCLPNMLPDDFCFDFQDPYGGNMVGNPSFSQDFFPDMSSSYVYGSRLLQESTLPSLSSSNITNENSEIPSNLPDDHRK
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVSRRQRPGSGQSEQWVLLAPESLSDDAKNLSDKTIFAKLRAPCTDKGSMFLFIDSGQQICEVKAFHEEYRSWFIGQTVQQDGRLLIATPIDPMFLVLHYLIKADKEQGKFQPVEQIVVDEEFPSCSMLLQCTPVSKSLHHVTEEKEIGSKKFYKYSKEKTLVWLKKKVELTVKVLKSSNICVGGGVQSATFIRNTQGSDVKEEDYTRYAHGLISEYLTEDLREDLSKYLGLPDLSSPTPEPPVKKRKVSEAPVEAEEDYTKFNSDSKNKKSNSKMTAAQKSLAKVDKSGMKNISAFFSPKAKATK
The following text describes a protein:
Function:
Possible regulatory or functional link with the histocompatibility cluster.
Sequence:
MKSSHKKPFSGKQKKQQLSERRERKRGVAEKETEKNVQTEEELVSKTKTKLKEQIFATKRDLRPKLLGMETKEEIDERKKLADFPIDLTKRVNGRAIPLFDITGEELDIITRPPWNYNMTAEELDQNEKVIFEEWITKIIDEHPKNINYFESNLETWRQLWRVVERSQVVLMIVDVRFGCIQFNRKVAEWIKSLNKGFGVILNKSDLVDEKIVLEWQEYFLKQFGVKTLYVKTNQAIEGRTEDWDLESIRNEKKKEGGEKSYVKTTLQDFENFVMELKPPKEIKEEEKPIEQEEDDSKKIKPKEKKLVVGLIGNPNVGKSSLLNWLVGKKVTSVSSHPGRTKYLQTYNMNKHITLADCPGMMFPMINQSQLIQVICGIYPLSQLREPYSIVRFFLERLPLDKIYSIELTPNMTVMEFVEAYAQKKNYITGKAGRLDTHKAAREILTDCIRGRIVFMFEPPKLE
The following text describes a protein:
Function:
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Sequence:
MGNLSRARRVTAALGFIGLLFAVLGIIMIVMVPSIIKQQVLKNVRIDPNSLSFNMWKEIPVPFYLSVYFFNIVNPEGIIQGQKPQVQEHGPYVYREFRHKSNITFNNNDTVSFLEYRSYQFQPDKSRGQESDYIVMPNILVLSASMMMENRPGLLKLMMTLAFSTLGQRAFMNRTVGEIMWGYDDPLIHLINQYFPNSLPFKGKFGLFAELNNSDSGLFTVFTGVKNFSRIHLVDKWNGVSKVNYWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFRFVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSGLHPNPKEHSLFLDIHPVTGIPMNCSVKLQLSLFVKSVKGIGQTGNIQPVVLPLMWFEESGAMEGETLETFYIQLVLMPKVLHYAQYVLLALGCVLLLIPIIYQIRSQEKCYLFWISFKKGSKDKEAVQAYSEFLMTSAPKGTVLQEARL
The following text describes a protein:
Function:
Positive regulator of the expression of the slpA gene. When overexpressed, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for the Lon ATP-dependent protease. Part of the cryptic P4-like prophage CP4-57. Overexpression of AlpA leads to excision of the CP4-57 prophage by IntA. This inactivates ssrA (the gene upstream of the prophage) that encodes tmRNA which is required to rescue stalled ribosomes in a process known as trans-translation.
Sequence:
MNNRSAVRILRLPAVIQKTGMARATIYDWLNPKSPRYDATFPKKRMLGVKSVGWIEAEIDEWLSQRCKLI
The following text describes a protein:
Function:
Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. Shows a preference for benzoquinones; Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines. NADPH is the preferred electron donor for azoreductase activity, but it can also use NADH. Can reduce different classes of azo dyes, including the common azo dyes methyl red and p-aminoazobenzene sulfonamide (PAABSA). Can activate several azo pro-drugs used in the treatment of inflammatory bowel disease (IBD), including balsalazide, sulfasalazine and olsalazine. Also acts as a nitrodeductase, and can reduce and hence activate the nitroaromatic drug nitrofurazone, a broad spectrum antibiotic.
Miscellaneous:
MISCELLANEOUS: Rate of quinone reduction is higher than reduction of azo substrates, suggesting the enzyme is better suited for carrying out quinone rather than azo reduction.
Sequence:
MSRILAVHASPRGERSQSRRLAEVFLAAYREAHPQARVARREVGRVPLPAVTEAFVAAAFHPQPEQRSLAMQADLALSDQLVGELFDSDLLVISTPMYNFSVPSGLKAWIDQIVRLGVTFDFVLDNGVAQYRPLLRGKRALIVTSRGGHGFGPGGENQAMNHADPWLRTALGFIGIDEVTVVAAEGEESGGRSFEDSCDEAEQRLLALARSA
The following text describes a protein:
Function:
Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Seems to act preferentially on dsMRNA.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Domain:
Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity; In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MEMGVMENLMVHTEISKVKSQSNGEVEKRGVSVLENGGVCKLDRMSGLKFKRRKVFAVRDFPPGCGSRAMEVKIACENGNVVEDVKVVESLVKEEESLGQRDASENVSDIRMAEPVEVQPLRICLPGGDVVRDLSVTAGDECSNSEQIVAGSGVSSSSGTENIVRDIVVYADESSLGMDNLDQTQPLEIEMSDVAVAKPRLVAGRKKAKKGIACHSSLKVVSREFGEGSRKKKSKKNLYWRDRESLDSPEQLRILGVGTSSGSSSGDSSRNKVKETLRLFHGVCRKILQEDEAKPEDQRRKGKGLRIDFEASTILKRNGKFLNSGVHILGEVPGVEVGDEFQYRMELNILGIHKPSQAGIDYMKYGKAKVATSIVASGGYDDHLDNSDVLTYTGQGGNVMQVKKKGEELKEPEDQKLITGNLALATSIEKQTPVRVIRGKHKSTHDKSKGGNYVYDGLYLVEKYWQQVGSHGMNVFKFQLRRIPGQPELSWVEVKKSKSKYREGLCKLDISEGKEQSPISAVNEIDDEKPPLFTYTVKLIYPDWCRPVPPKSCCCTTRCTEAEARVCACVEKNGGEIPYNFDGAIVGAKPTIYECGPLCKCPSSCYLRVTQHGIKLPLEIFKTKSRGWGVRCLKSIPIGSFICEYVGELLEDSEAERRIGNDEYLFDIGNRYDNSLAQGMSELMLGTQAGRSMAEGDESSGFTIDAASKGNVGRFINHSCSPNLYAQNVLYDHEDSRIPHVMFFAQDNIPPLQELCYDYNYALDQVRDSKGNIKQKPCFCGAAVCRRRLY
The following text describes a protein:
Function:
Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is unknown.
Sequence:
MATQSSPVITDMKVIPVAGHDSMLLNIGGAHNAYFTRNIVVLTDNAGHTGIGEAPGGDVIYQTLVDAIPMVLGQEVARLNKVVQQVHKGNQAADFDTFGKGAWTFELRVNAVAALEAALLDLLGKALNVPVCELLGPGKQREAITVLGYLFYIGDRTKTDLPYVENTPGNHEWYQLRHQKAMNSEAVVRLAEASQDRYGFKDFKLKGGVLPGEQEIDTVRALKKRFPDARITVDPNGAWLLDEAISLCKGLNDVLTYAEDPCGAEQGFSGREVMAEFRRATGLPVATNMIATNWREMGHAVMLNAVDIPLADPHFWTLSGAVRVAQLCDDWGLTWGCHSNNHFDISLAMFTHVGAAAPGNPTAIDTHWIWQEGDCRLTQNPLEIKNGKIAVPDAPGLGVELDWEQVQKAHEAYKRLPGGARNDAGPMQYLIPGWTFDRKRPVFGRH
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3 with a specific activity for H3K27me3 and H3K27me2, and involved in the regulation of gene expression. No activity on H3K27me1. Together with JMJ30, regulates the flowering-repressor FLOWERING LOCUS C (FLC) locus by removing the repressive histone modification H3 lysine 27 trimethylation (H3K27me3), especially at elevated temperatures (e.g. 29 degrees Celsius), thus preventing extreme precocious flowering. JMJ30 and JMJ32 are regulators involved in the integration of abscisic acid (ABA) and brassinosteroids (BR) signaling pathways. Together with JMJ30, controls ABA-mediated growth arrest during the post-germination stage in unfavorable conditions, and responses to ABA during root development, via the removal of repressive histone mark (H3K27me3) from the SnRK2.8 promoter, thus promoting SnRK2.8 expression and subsequent kinase-dependent ABI3 activation. In addition, removes the repressive histone marks (H3K27me3) from the BZR1 locus in response to stress and ABA, thus activating the BR signaling pathway which, in turn, inhibits the ABA signaling pathway.
Subcellular Localization:
Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Predominantly localized in the nucleus.
Sequence:
MAKEIENLWREVRELSLGTKIDRFDSQPSPVKFLRNYVSQSKPCVISKAITHWPALKLWSDPAYLTGALSDDVVSLHLTPNGCADAVTGDSDLCFASAHVEKVLFPEALKVVQSSCKGLKVGYLQQQNDCFRTEYSTVALDCDGDIEWATEAFGCSPEAVNLWIGTDDSVTSFHKDHYENLYAVVSGEKHFLLLPPTDVHRLYIEQYPAANYSYHRDTDAFKLEVEEPVRHVPWSSVDPYPSPEKEASERLKFPLFFDGPKPFHCTVKAGEVLYLPSMWFHHVSQTPGDGGYTIAVNYWYDMQFDIKYAYFNFLQSLLYKSSSLNPVLSWREDEDSESSDAEIAP
The following text describes a protein:
Function:
Plays a role in immune evasion. When secreted, inhibits T-cell activation by preventing the binding of host CD80 and CD86 to soluble CTLA4 and CD28. In the infected cell, may inhibits host NF kappa B activation.
Subcellular Localization:
Host endoplasmic reticulum. Secreted.
Sequence:
MVYKLVLLFCIASLGYSVEYKNTICPPRQDYRYWYFAAELTIGVNYDINSTIIGECHMSESYIDRNANIVLTGYGLEINMTIMDTDQRFVAAAEGVGKDNKLSVLLFTTQRLDKVHHNISVTITCMEMNCGTTKYDSDLPESIHKSSSCDITINGSCVTCVNLETDPTKINPHYLHPKDKYLYHNSEYSMRGSYGVTFIDELNQCLLDIKELSYDICYRE
The following text describes a protein:
Function:
Could be a drug efflux pump.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYEEIRMKFTDIFIRRPVLAVSISLLMIILGLQAISKLAVREYPKMTTTVITVSTAYPGADANLIQAFVTSKLEESIAQADNIDYMSSTSAPSSSTITIKMKLNTDPAGALADVLAKVNAVKSALPNGIEDPSVSSSSGGSGIMYISFRSKKLDSSQVTDYINRVVKPQFFTIEGVAEVQVFGAAEYALRIWLDPQKMAAQNLSVPTVMSALSANNVQTAAGNDNGYYVSYRNKVETTTKSVEQLSNLIISSNGDDLVRLRDIATVELNKENDNSRATANGAESVVLAINPTSTANPLTVAEKIRPLYESIKTQLPDSMESDILYDRTIAINSSIHEVIKTIGEATLIVLVVILMFIGSFRAILIPILAIPISLIGVLMLLQSFNFSINLMTLLALILAIGLVVDDAIVVLENIDRHIKAGETPFRAAIIGTREIAVPVISMTIALIAVYSPMALMGGITGTLFKEFALTLAGAVFISGVVALTLSPMMSSKLLKSNAKPTWMEERVEHTLGKVNRVYEYMLDLVMLNRKSMLAFAVVIFSTLPFLFNSLSSELTPNEDKGAFIAIGNAPSSVNVDYIQNAMQPYMKNVMETPEVSFGMSIAGAPTSNSSLNIITLKDWKERSRKQSAIMNEINEKAKSIPEVSVSAFNIPEIDTGEQGPPVSIVLKTAQDYKSLANTAEKFLSAMKASGKFIYTNLDLTYDTAQMTISVDKEKAGTYGITMQQISNTLGSFLSGATVTRVDVDGRAYKVISQVKRDDRLSPESFQNYYLTASNGQSVPLSSVISMKLETQPTSLPRFSQLNSAEISAVPMPGISSGDAIAWLQQQATDNLPQGYTFDFKSEARQLVQEGNALAVTFALAVIIIFLVLAIQFESIRDPMVIMISVPLAVSGALVSLNILSFFSIAGTTLNIYSQVGLITLVGLITKHGILMCEVAKEEQLNHGKTRIEAITHAAKVRLRPILMTTAAMVAGLIPLLYATGAGAVSRFSIGIVIVAGLSIGTIFTLFVLPVVYSYVATEHKPLPVFDENKTTH
The following text describes a protein:
Function:
Involved in biosynthesis of legionaminic acid (5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates such as lipopolysaccharide (LPS) which could be a key determinant in the ability of L.pneumophila to inhibit the fusion of phagosomes with lysosomes. LPS contains a majority alpha2,4-linked homomer of legionaminic acid. Catalyzes the conversion of N,N'-diacetyllegionaminic acid (Leg5Ac7Ac) and CTP into CMP-N,N'-diacetyllegionaminic acid (CMP-Leg5Ac7Ac).
Sequence:
MRILAVIPARAGSKRLPGKNTRLLAGKPLIAHTIVAALQSSCCEEIVVSTDSKQIADVAVQYGASVPWLRSEDLATDTSDVIHTVIDLLFKFQQMDVFFDSVLLLQPTSPFRKPETIRHAVEIHKVTGKSVVSVSPISLKPSWCRSIDSQGNLVKPELFQDLEIYCNENPIYKLNGSIYIATAKQIIENKSFYSEPTKPLLLNSISESIDIDTPIDWALTEKLMELNQEALV
The following text describes a protein:
Function:
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE
The following text describes a protein:
Function:
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.
Subcellular Localization:
Lysosome membrane; Peripheral membrane protein. Secreted.
Sequence:
MGFHLALFLFLASLRLISTQDIEHGSIEVNGVQGIAENDDNFICATIDWWPQEKCDYNYCPWGSSSVLNLDLSNPILAKVIQALRPLRIRVGGSLQDQVLYEVGSLKSPCQNFQKMKGGLFGFSKGCLHMKRWDELNHFFKNTGFSYVGGYCKSVTKSHKIYLLKSKNITCCHFSVAWAMVTFGLNALRGRHQISRKVWGGDWDPTNAYDFINYTISKEYEIDSWEFGNELSGQGIGASVDAAQYGKDLIKLKQNLNKLYKYTKFKPSLIAPGGFYQKEWFDKLLEVSGTGVVDVITHHVYNLGPGNDAHLENKILDPAHLSKVESIFSNLSETIQTHGPWSAAWVGEAGGAFNSGGRDVSNTFVDSFWYLDQLGLASRYNTKVYCRQTLIGGNYGLLNVTTFTPNPDYYSALLWHKLMGKGVLAASSDVFSPFLRTYAHCSKGRDGVTLLLINLSNQTKFILNVHDSVHVSNGENEDAKSNTHMDNSFINQLKKAFSWVGTKLSDVTFREEYHLTPEDNDLNSKTMLLNGSPLKLTDDGEIPKLDPVLNNVYSSIHVDPLSIAFIVYPNLDAPTCFGNSKL
The following text describes a protein:
Function:
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MADRPTNNSKLSLPPISLHLLSGALSGLASCVLLQPFDLLKTRLQQAHISSNPSSSSTRPSIYRLSSEVISRDGILGLWRGTSPTIIRNVPGIAAYFFGLAQLRTSMSSISIFTQQSQPLHLLHQPNILPTLTPTGDFFAGVLARTSVGFVLMPVTVVKTRFESNLYEYRSIRAAFQEIMRTQGLQGLWRGFIPTALRDAPFAGVFISAYEATKRLLVEPGQRYPILLHTVPATAAAVVATLLTAPFDLLKTDLQLRQSSSHNPSILQALKLILNGRLSNSRILFKGSGLRLLRKSLSSAIGWTLYEGLIKKWAIKN
The following text describes a protein:
Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
Subcellular Localization:
Cytoplasm.
Sequence:
QFEKILKEKWNEATDFGLFKYSLKNLKSKVTVGRKQFVLQLNEKRFSERRIPYTYNSCIVPFDDKEFNFNKVLPGEILFEFKCASKDITVSKCGETDVVLINNSPLEKFHVLLIPAITQCTNQKITKELIEMCLNFILLCPSKGWRIGFNSLCGFASVNHQHAHAWKLKLPLFIESAPVLHVKDDFYILNDSSNHAIAFQLDGDNVTKLIRHVCDCAIYLQNNEIPHNLFITRGSHFNFPLRSTIRIFIWLRKKFVASAQSKGFNVACAELAGHIPVYGKM
The following text describes a protein:
Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins; Required during spermatogenesis for sperm head elongation and acrosome formation. Also plays a role in acrosome attachment to the nuclear envelope.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein. Note=Restricted to the inner nuclear membrane facing the acrosomal vesicle. The N- and C-termini are oriented towards the nucleoplasm. Colocalizes with FAM209 at the inner nuclear membrane.
Sequence:
MVGPTRSKLREGSSDRPQSSCTGQARRRWSAATMEPQQERSAPQERTKWSLLQHFLLGGRKLPSGARNYAARRIQSLNAQNYFQLEEVAKLLLLNRFQFLFTLLDHFREKVQALQMHRFSHRTLFGLAIFVGILHWLHLITLFENDHHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLVINTVKRFHLYPEVVIAYWYRTIIGIMNLFGIETKTCWNVTRMEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFFIYSTYLSGSQLGGLITVACYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTIILRTSTVHKKHYMALCFSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYVNMSSVALCFILMFGNSMYLSSYYSSCLLVTWAIMQKKSKIQKLGGTELQFWLIQGCFWWCGTIILKFLTSKICGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMEQATPLRYIKTLLLPLILVITYLIFKKIVRDIMCVLYTNTYVRKQLLDNAELIFHTLQLLAFTGLAILIMRLKLFLTPHMCIMASLICSQRLFGWLFCRIHFENVVFGILTMMSIQGCANLHNQWSIMGEFTNLPQEELIHWIKHSTRPDAVFAGAMPTMASIKLSTLRPIVNHPHYEDADLRARTKIVYSVYSRKSAVEVRNNLLKLHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSILLKDSRPYFTTVFQNSMYRVLKIN
The following text describes a protein:
Function:
Acts as a mitotic inducer. In G2 it negatively regulates wee1, a mitotic inhibitor. Also has a role in cytokinesis where it required for proper septum formation.
Sequence:
MSTISEVGPWELGLSLGSGGPNSSRLAKHRETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIEHPNVLQLIDVISAQEQLFVVVEYMPGGELFDCMLRKGSFTEQDTAKFLWQILCGLEYCHKLHICHRDLKPENLYLDAHGSIKIGEFGMASIQQPGKLLQTSCGSPHYASPEIIMGRSYDGCASDIWSCGIIFFALLTGKLPFDDDNIRSLLLKVCQGQFEMPSNISPQAQHLLYRMLDVDSSTRITMEQIREHPFLSCFVHPNISIPIISAPIQPIDPLIVQHLSLVFRCSDDPMPLYEKLASQSPLVEKTLYTLLSRHLHPPSSAAVDRNRAVVDDLLGTAASNGQQMDEEEIEQAINIPTLAPYPISYAAESVPRPATSASPFLTPVTTSGTFNYSFNATNPQSILQRPATTSSAVPQLPKSVTPGLAYPHDSSMLSSNYRPPSALSPRNFNVSINDPEVQLSRRATSLDMSNDFRMNENDPSIVGNLAASNFPTGMGPPRKRVTSRMSEHTGNRVVSFPRGSAFNPRVTRFNVGNEQFSNNIDNNNYNQPYANATMNNSRRLRTPSGERSMRADLSQSPASYDSLNVPKHRRRQSLFSPSSTKKKLSGSPFQPKRSFLRRLFSSEPSCKCVYASLVASELEHEILEVLRRWQLLGIGIADIIYDSVSASISARIKRQNSLNLKPVRFRISVLAEFFGSQAVFVLESGSSTTFDHLATEFQLIFEDKGFLDNLELSYFQASASRPVSRMSVSSSPFAVFRQRQSVQS
The following text describes a protein:
Function:
Catalyzes the first reaction in the catabolism of the alkaloid lupanine. It dehydrogenates lupanine, which can then be hydrated to produce 17-hydroxylupanine.
Subcellular Localization:
Periplasm.
Sequence:
MSANKNIWIIRLGVAFVCVAIGAAQANEKDGSAVTSGNWSLLGGGNEQHYFSALKDVNKSNVKNLGLSWFTDMEAGDGLVGNPLVADGVIYQGGPPGKIYANDLKTGKNLWTYTPEVQYDKDTSWTGFWGTHVNRGLAVDDDNVYIGSYCKLLAVSRTTHKLTWSSQSCDPKKMQAITGAPRVGGGKVFIGNASGDFGGDRGHLDAFDAKTGKHLWRFYTMPGDPSKPFENDLLAKASKTWGTDYWKYTKGGVSPWDAITYDEASDTLYFGTDGPSPWSPAQRAPDAGDELFSHSIIAVDASTGAYKWHFQTVQNDGSNMSATMHIMLADLPVEGVSKRVVMTAPKNGYFYVLDASTGKFISADHYVPVNWTKGLDPKTGRPIPSNEANYWERPGEMTIPLPGDVGGHNWEAMAYNPELRTVYIPSTLVPVTVVASKDTGELDLDYYYGMRPDATIKTQGDLVAWDPLLQKEKWRAKRSLPVNGGVLATAGGLVFQGTGDGHFEAFDANTGEKLWSFHVGGSILAAPTTVEVDGDQYLIVASGNGGASGMRGIPRLMNNLQSQGPARLLAFRLGGKTELPITSTPDFPKPQYPKPTSAMAESGRHIFNANACGACHGFNAEGSTPGLPDLRRSDKLDLAVMKSIVIDGAFKPLGMPGHPHISDADLQALQAFILQKAWTAYDTQQTLKTSDTGAQ
The following text describes a protein:
Function:
Regulates arginine biosynthesis genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKKANRLDAIKMIISSKEVGSQEELLQELNREGFELTQATLSRDLKQLKVAKAASMNGKYVYVLPNNIMYKRSTDQSAGEMLRNNGFISLQFSGNIAVIRTRPGYASSMAYDIDNNEFSEILGTIAGDDTIMLVLREGVATSKVRQLLSLIIPNIE
The following text describes a protein:
Function:
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKIRIAHPFWDWVLSAIFLTGFPIVVLFSLNYPNVILQQGTAHRIFYFHVPVAWVALYGPIFSLIFAVLYLIRKESKWDLLSLSANQIALLFAVGVIFSGRIWAASAWGVPWDKTDARLQSFTVLFISLIAYFVFRILITDVSKKKIFSAFLSILCAINAVITWGAIRWIDNPGNHPESIMGKGGMDSDIRLSFWLGVLAYHVLFLVLFRFVYRLSKIENLKENLPEREA