lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an essential role in nucleocapsid entry in host nucleus. May act by binding and stabilizing F-actin in the infected cell, which might attach to nucleocapsids and then push the nucleocapsids into the nucleus.
Subcellular Localization:
Host cytoplasm. Host nucleus. Virion. Note=Present in both the budded virus (BV) and the occluded virus (OV). The occluded form allows the virus to be transmitted from insect to insect through ingestion of contaminated food while the budded form is responsible for the dissemination of infection throughout the insect host.
Domain:
Contains a domain homologous to an NEBU domain that is known to bind actin.
Sequence:
MSDKTPTKKGGSHAMTLRERGVTKPPKKSEKLQQYKKAIAAEQTLRTTADVSSLQNPGESAVFQELERLENAVVVLENEQKRLYPILDTPLDNFIVAFVNPTYPMAYFVNTDYKLKLECARIRSDLLYKNKNEVAINRPKISSFKLQLNNVILDTIETIEYDLQNKVLTITAPVQDQELRKSIIYFNILNSDSWEVPKYMKKLFDEMQLEPPVILPLGL
The following text describes a protein:
Function:
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
Subcellular Localization:
Membrane.
Sequence:
MPSVGSHMQQYGQGPSCWDRIKLGFGIGFAVGISAGALFGTFASLRMGLRGREFVGQVGKTMMQSGGTFGVFMSIGTGIRC
The following text describes a protein:
Function:
Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity).
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Mostly cytoplasmic, but associated with the mitochondrial inner membrane during the last steps of spermatid differentiation. Localizes to the principal piece of the sperm flagellum (By similarity).
Sequence:
MAEDGLPKIYSHPPTESSKTPTAATIFFGADNAIPKSETTITSEGDHVTSVNEYMLESDFSTTTDNKLTAKKEKLKSEDDMGTDFIKSTTHLQKEITSLTGTTNSITRDSITEHFMPVKIGNISSPVTTVSLIDFSTDIAKEDILLATIDTGDAEISITSEVSGTLKDSSAGVADAPAFPRKKDEADMSNYNSSIKSNVPADEAVQVTDSTIPEAEIPPAPEESFTTIPDITALEEEKITEIDLSVLEDDTSAVATLTDSDEKFITVFELTTSAEKDKDKREDTLLTDEETTEGASIWMERDTANEAETHSVLLTAVESRYDFVVPASIATNLVEESSTEEDLSETDNTETVPKITEPFSGTTSVLDTPDYKEDTSTTETDIFELLKEEPDEFMI
The following text describes a protein:
Function:
Probable high affinity receptor for melatonin. Modulates potassium channel slo-1 activity to inhibit neurotransmitter release at synaptic junctions and promote a sleep-like state, called lethargus, during larval development. May function presynaptically to regulate synaptic transmission. Required in rectal epithelial cells to promote pathogen clearance, acting upstream of multiple G proteins including egl-30.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWPPVDVRSLTAESLGRASLILAVDLLLFVTSILNITVIAFTPDLSDVIGCYLISLSVADLLTAIFVIPLSIYSTLEGNWRIGGDNSIICKSAAYLQIALFCSTVYTFAWICIDRYSAMMKPSRYSEQSLTRCKCWIVFSWLTSMLLCCPIIVARMQVVFYPDAQLCVLDWSATSAYSVTLLLLVFVPTLVTVFNTGWKIWSAMRNPAALDDSQRMLVETDPNFVLTGFLFVTFFLSWLPLITLKVCELIWGPFDMDLSMLTFFFVWLAVSGPCCKFLIYMFTNHQFRRSFLSYISCSMCCSSRSRYEYHDIGNNSFL
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Miscellaneous:
MISCELLANEOUS: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MINNINRIKKTYNTFLNVNKLRYSTSIISSNILENDNNNIDDFEQVLKSTKVRMPTSALLLPKKPKVCIGMSGGVDSTITAKLLKLQGFDVTGVFIKSWDEVEDTGRCQGERDWKDALEASNFLDIPMYKADFVKDYWNRVFVDFLKDYKNGLTPNPDVWCNREIKFDLFFDFAKENFGVDYIATGHYSNLYYGEENVGDNNNNNLQLHRAIDKNKDQTFFLCMTKGERLKQAIFPIGGFTKENIVSFAKTIPNFSKITSKKSSRGICFIGKRPLPDFLSQYMTLKPGDFFDISTNSFIKGKKHKGSVCYTMGQKANIDSLSERYFIVRSDIERNIVYVCPESQFDQFSLYYEFNTHSFNWINEIPTEVKSEQGFKGRGICRHRGDVVNLTIKDTGKTSPIDGSVIYSVNLDQPLRSVASGQILCLFDRNTDRCFGGGVINSSPLYNPTQF
The following text describes a protein:
Function:
Member of the two-component regulatory system GcHK/Anae109_2439. Autophosphorylates in response to oxygen availability, and then transfers the phosphate group to a conserved Asp residue in the receiver domains of the cognate response regulator Anae109_2439, resulting in its activation.
Domain:
Consists of two domains: an N-terminal heme-based oxygen-sensor domain, and a C-terminal catalytic domain that exhibits histidine kinase activity. The coordination and oxidation state of the sensor domain heme iron profoundly affect the enzyme's catalytic activity.
Sequence:
MTGVPETVFEELKRYVGWGDGDERALRSLHGAAAPHFPRLAEEFYDRILGHEGARTALVGGESQVGHLKVTMIAWLDELLGGPWDEAYWDRRYRIGRVHVRIGLPQHYMFGAMNVHRTGLARLAYERFHGDPPELERVRNALGKVLDLELAVMLHTYREDLLAQQARVERLSTFGQLVGSIGHDLRNPLGVIETSLYILRTRTGEDERARKHLDRIGEQLGVANGIITNLLDMIRDRPLAREPVELAAVVGGAAESVRRPTGVSLALEGLDALPPVEGDPGQLRQVFVNLLENAVFAASPEGVVAVRASRADGLVALDVEDSGPGVDPATRRRLFEPLITTKDKGIGLGLALVKRIAERHGGTVEYSDRPGGGARFTVRLPA
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MFIVYYSNQLEKQKEILSSLFKSLPPEDPFQQDIILVQSPNMAQWLQIELAKETGISANLKFPMPASFIWQLYAQNLPATALENPFDKDSMMWRLMRLIPIFLEKENFSPLRNYLSSSPHSEQYKLYQLSSKIADLFDQYLVYRPEWIFAWEKGEDEQITDQIQKQQPNLNATLFAQIQGNTKWQGELWRALVVDVKSDVNEATHRAALHNQFLALLADKKAPKKLPSRIFIFGIPALPTAYLNILQAISSEVDIHLFFNNPCQEYWGDISDLRLDYLRSRQRYQFNKQDENQPLFSEDQLSQLENAQFDVTYQKENLQLGNPLLAAWGKMGRDFLYILVRDEEHIPTYPVNAYQEIESNSLLGQLQSQILHLENKPLNIAKNDRTLTLHSCHSAMREVEVLHDYLLDLFNQDPSLTPKDVVVMVADINQYTPYIQAVFGQKNGDVPQIPFSLSDNKLSESDVLVSSYLTLLRLKESNFSAEDVLVLLDIPAMRERFNISLADLPLVREWVTDSGIRFGLQKNQDGINFNSWQAGLERMILGYAMREEQGIWQDSLGLNSSYGLKGELAGNLSHFFTALSALHETLQQAHSIEKWQEILTALLSDFFVRNEDTSDMIFYIQEKINELAEHLKTLHFNEELQAEVIADVITMQLEDAPNSLKFLAGKVNFCTLLPMRSVPFKVVCLLGMNDADYPRTQTPNSFDLMQYHYQKGDRVRRDDDRYLFLEALLAARDYCYISYVGRSITDNQPKEPSVLVSQLLDYINQGQKENVLTVIEHPMTAFSPDNFKNNEKFTRSFATKWLPIAQFDASSNNSEFAVTMTENLEKIEEVELDALVSFVENPVKFFFEKQLGVYFRDKDERIADSENFTLSGLDNYSLNNDLIYLDEQNFADYFRQAEVKGVLPRAEFGKVYAENIRDNVLEFKKKIADLGEAKHASVDFNLSVDWQNENQKIRLFGYMDALFGDDSQVIHWHFAKYKDRYCIRPWIYYLIQCVTQENAVPAKLITQDKVLELPPIEREVALAQLQIYVKDYLQSQIEIQLVPTVRNISDFIVSDENSVSEKLQELTESNGFGPKADPYWSRVLAQTSRFKQPENIAKLLKQTKAWFGLLFAQKKTRKTQS
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSTYSSIQRHRKDTSSSGSNTTPLARRRRFDEGPADPGSAPHLDSFVVPPTRHDDGTKRQPGRRKQRWSHGENKVADLLQMPTALTGHLTPEQAEAYAIYYRIEEISQQLRLGDIVPPEDERSPSPPPQYDSMGKRTNTRDARYTRQLEEERHRLIERAQRLIPNYRPPVDYHKPAKTQEVVYIPVNEYPDINFIGQLLGARGKTLKKMEQESGAKICIRGRGSVKQGKGRTDIPFQSTAEDDLHCLIISEDEEKIARAVQLVQQVIDTAASVPEGQNELKRSQLRELAALNGTLRDDENYGGAPQSSSGDEMDDRNKRRNNFMSSIVCHICGSKGHFARDCLEKGTNAGTSENADREYDALMRELQGEGVIDTASQQQSIAQNPNTNNVSKLPPAVTGSNAAPINMRKPMSERGGSFDRFDRGGFNQSNQREPQQQSHQQNMHNTNGNNYDRYDRNFNNSSNSSPELPPWHRPTPPSQPAAPPWLRRDNYKKHDKVSVQQSMQQSPWNRDTRQHQHQHQPPVHHQSMFNNNQSPIGPPGMSSSGFGGYGGAPAGVPGMSVPPGPPGLSKVPPPPPPPGVPGMDGDQPIRHPPPPPPGVIGPPK
The following text describes a protein:
Function:
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MESSLTELPTLLPNQSMDSCPPVENTAENMMFGIYYIIVFLLALSGNSLALWIFARQRNNSSPANVFLLHLAVADLFYVFILPLRATYHLTGGHWPFGEIPCRLAGFFFYVNMYASLYFLACVAGDRYLAVVHAVRSLKVRRPHYAHIASFALWILVIVSMAPLLITKQTVEVNGSTVCLQLYREKASWRALVSLVVAFTPPFIATLSCYLLIVNSLRKGSRLEPALKLRALRTIGLVMFIYVVCFLPYHLSRATFILGYGHPDLSCQIKRGLALANRLTSSLTCLNGGLDPLVYLFAAEKFRGSVRRIFCRDKSGGSGATSGELKGTHESSLSAKSEF
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). Required for lipopolysaccharide (LPS)-enhanced bacterial clearance through the autophagic pathway.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Domain:
Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.
Sequence:
MSHEDRGGDYYPMMDDPEDRNFIQAKYPNSTGHMSSGGGSNHMSFDDNHGIEMLRDDEHSLLHESPVSIPAIHNLDSFLTDVYNYFRGKGFMCIFFNDLFELVSSLFVVLFFTFLVCFVDYSKLFSEQMPPPALRESVNFSAPIPIWLMVFLVIFSLYWLSKLFSFFSSIKTNWEISSFYKNTLKINEDDIQTIEWREVVSKIVLVPRLCIVKENMNALDIANRIMRKENYIIGLINQRILNLSIPFPFLRNLTFITKTLEWSLMYSLFNYIFDENGIIKSEFQDPTQRKRLSRGLSRRFMTIGILGLFTTPFIFFFLLINFFFEYAEELKNRPGSLFSREWSPLARWEFRELNELPHYFQNRLNLSYSHANQYVESFPSQMLSTIAKFISFLFGSVLAVFIVLGIVSDHFIMNYQIFDRTPIWYIGILGTIVAITRSLIVDENQVFQPAKHMARTVQNTHYLPMSWVGKTHTHKVRDEFLVLFEYRIVDFVRDIFSVLFTPFILIFSLPKSSQAIIDFFGNNTVVLEGVGPICQLGDFSNIRKLGDNSFGSLNHSQNKISLTNNAKLEKSIINFKCLNPEWNTDNNELLQNLNEFSKIKNNNNNNNNNGSNNHIGNHSQLPTTSVDDFQFIHDSHYIPHEIIDAVLGTHHHSQQSNNNAPRFKTGRVDQNILNAVNDLHQSFYESQYKHKNDNFVNSI
The following text describes a protein:
Function:
Weakly suppresses a RAD53 null mutation when overexpressed.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLKTPNWETVNETPKSRVLTINELISPNLDTESNSLLATPARKYFKTSISEAQDSPTSAPSPDGNEDPTYQYNVQFHFPGPITPTTPRSKNAEMFPSPTPPLVSPTAVIEEENDDSVREFSRTLKSRLNCAMVKLSKEHEQVALIPPPPTEKIRKGSYSNKFAAKHRRCHSLDESKKFLSSLEDSSAHAAFLKAISSKHAKSNRVDNVNVSPLRWSSHRRTQSTQENSLQEVVAIDTLLKMSSSD
The following text describes a protein:
Function:
Necessary for normal cell division and for the maintenance of normal septation.
Sequence:
MKVKFLGSFFEEFPPPDYPEVVFVGRSNVGKSSLLNMVVGSKVAKVSKTPGRTRAVNYFLLDKKLYLVDVPGYGYAKVGREEMEKWRKMMERYFKERKDNIKMAFLLIDAVAGVQPLDEQMIEWFEYYGIPFTVVITKIDKASQSEIAKTLKQVKRYVGDGAIVLSSAKEGKGKKELLSRILN
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MVDFELLQIIRYASCHQPYIYVYCFIRMVNLLKRHSFSRSTNLMVSFLQLFAMLETALGSFPDVGASYYLSRLPGFFGEYVGLTGARLDGAEMLACGLATHFVPLEVLTIKFATVCCRLKTINSCFSRRTVEEIISALEEGDKNMDNWISWTIQALKKASPTSLKISLHSVSTYHALDFIYI
The following text describes a protein:
Function:
Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGGGEGGAGGEPAAGAAPAAAAQATLHIRGTSGNKFAVRADLGATVGELKAVVAGSCDVPAPQQRLIYKGRILKDDQTLASYGVEADHTIHMVRGAAPPATSAAPAAANLGTSTTTPANTPPAGLGGLFQGLGSTGTAGSGAFGLSASGLPGLEQMQQQLTENPNLMREVLNTPAMQNIMNSPDLIRDLIMNNPQMRELVDRNPDLAHVLNDPSILRQTVEAARNPELMREMMRNTDRAMSNIESSPEGFNMLRRMYETVQEPFMNATTMAGEGDTTPNPFAALLGDQGSNQARDPTGDAPTTAPAPNTNPLPNPWGANAGAAQGAARPSAAARSATSGGLGGLGSADLGSMLGGGSDASLLNQVIQNPAMMQMMQNIMSNPQTMNQLLNMNPNVRNMMESNTQMREMFQNPEFLRQLTSPETLQQLASFQQALTSQLGQQAAGQERTQAGTTPGNVNLNSLMSMFSGLGAGGGLGGVPNVPTVPPEERYATQLAQLQEMGFFDPQENIRALLATNGNVHAAVERLLGNFGQ
The following text describes a protein:
Function:
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKAMPWNWTCLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRFASEMKQCVRLTVHPNNISVSQYNVLLVLETYNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIITENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHDPKTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVHLYKCGAMRESCGLCLKADPDFACGWCQGPGQCTLRQHCPAQESRWLELSGANSKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEVLNATEMTCQAPALALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEAFGPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESPNLIGRHKVMARVGGMEYSPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSKQVTAYNAVNNSTVSRTSASKYENMIRYTGSPDSLRSRTPMITPDLESGVKMWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLMSLDS
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MGFTYKLTFLFFMAAFVGAVDKEKPDFAGIFKQKGLDNFLKEGVSLLQKQLYQIQLPEFSGSQKFGFLGSAKYKLYSLALKKVELPNYQVSPLPNSGLKLSISGVLIDVDGRWEVRFGFIHEDGTFNIKVKGLSISVGLILGKDGSGKPTISLSECSAHISNVEVHMSGTIGWLVELFHNKVESELKTLLENKICPEITQAINTQLLPLLQNLPGGIF
The following text describes a protein:
Function:
Sugar transporter involved in the transport of CMP-sialic acid from the cytoplasm into the Golgi. May transport important nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-octulosonic acid) in physiological conditions.
Subcellular Localization:
Golgi apparatus membrane. Membrane; Multi-pass membrane protein.
Sequence:
MMLVEGAMRRHRREAARCGGRGGGGVAREGVTGASTLHRGSAPTPLRARPASVTPRPPPPTISLCDPAPLLRTSPLIQRNPSTSSPTPWLRRRLRDPRDRASLRAILARARPPDKAVAGRGHAAVHAATRAGHLPRGQQSALCPHLPLRARTRPIHEQALAARRGRLLAAPSARLEAPEAQPRRSLRRRSKPSDSHPSSPVSFPNPTPSLLGPPLPLSLRPRRQHPHRPPPPPPALLNRFAESRCSKGTYTELLVMPDNVVDVFLFCLIAGYSICWFNTVCFVLCIRSFSASNRSLALSLSISFNGLSAPFYTLFANALSPFSPAVYLLLNAILPLAVSVLALPAILLCHKNEGHIQSAMVLLALPLIIPACSSCSYVDTDGPDPAYDDPHKPLLISNSHQMESNAMMQKPKENQMQVKGRLETLGEEHSAKKLIRCVDFWLYYTAYFCGATVGLIYNNNLGQIAQSLHQQSQLTMLLVVYSSCSFFGRLLSTLPDLLHRKVSLARTGWLAAALVPMPMAFSLCGTNKMEAPCVGVNHNILITNIPLGSLLYGQIAAMVYDANGQKMTVVDNRTGIVDTMIVCIGVKCYSTTFVVWACITFLGLITSFDEVRVYPIPVMLYLVKNLLQYYIFEYVDAPAYQILKNLNIISTGVLYRIILKKKSDHVLQTPIRGWVMAIVMALLSGFAGVYTEVIIKKNPSRNINAQNFWLYIFGMLFNLVAICVQDFDAVMNKGFFHGEVYMSTTIIWIKNISKMLPAQTMMQEELLPSLKMQKSECLLTNLKTP
The following text describes a protein:
Function:
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MLLDLARNLRQERLLIGSERQNLQTLNKKVSEALEKLHQLAWVASQQRINLDGLIISRLEVSPSFSCQQANALEGACFIEGYRHLGFHEALFSEFLQRLRENAPLLAVCLASGEKLSPETMPTVISVVTSSLYANFLLGDDEKYCLQLLKHLMELQLVSSENPRRLLRHGSCAFSRLYKAFTEGLFSAKVFLTAALHDPILFLLMEDEMYLDVDPIRAINRYPSYEREKRFGREGTQEFNSAIQKYRTTAIDRLVQLTQRFVSGLAASVACFPSSVAWLVRQMRSLLTHSMRIDARQVHAICVDLVFAFFICPAIVNPDPCGIVEAPISPIARSNLIQVAQILQVLVHSKWEPFDPKLDDLYSRFDKDCVSSILDAILDDGTPSANVAPFSPSSTQSSPSADPSVDTHRLLLGLNRSVALVTESELQTFVQFLRTVLTNDGLEANDKRTLESLLQPVPLLCSPVKSTLSQRKRNLLDKVNIRVRSKAANLLQRDSDHSFGIWSSSDDSGELGTPRHSNGEESPSSSGAVIGHVLVIPFSSKNEECIGMLSEQQVLALEQEKESTRASLDGSSVQGAEEMQQNPVQEKRTRFSLSHDEGSIGNTSDNLEAVSEAASNHSVESSVESENDEAEQDPIDNLSDMVSANVSGRGSPNVSGRDTPSSQVTEGDEGASRSGINEQRPLLMQAVPPKPSDIDDRFGRFDVKDLILGDETRSLVSDSWSTDVLGSDSELANETADRDRQPPLEDIVLPGRHLLVEAEAGLFDVSETASEAWSTDVVTSDTERMAEVDTDETSSVARSEADSEQDSTTSMLAVNAGSSHLGAIQRIRGRMSGSLFRPIREASVEQLQNLSLQSRSAPQQESSSNVSNGPMSSSSSSCSSHGSIASSAKGLATSTAAVAAMVNTTSSSAIGTATSISNGGQQASTGAIPKSISFDKTADRGDKENCYDDENKNKRGFFRNFKLPFKRGGRTKDRATAVDHPDNVNYTSYNRSLRRSASEEARTALATESSDDILAKYRSKGSNLAGQGDASASNGTQSMVAFNLAEEHSVDEDEGEDERQHIDPLNIESSYAFADAKRKLRLVLSTADVQSLHVMNNATAASNSTEHELIIFLKLQLAEAINLQDRSLVAQLHETLRCVRLFDAIGCSKLFHSLKEDYKGRAPYLSYLIQCRQSLLSVLAHLERLANRVEQDKAVCHRFLISVCVRLFLERREKQLNDFVVEFQQLHAADEKADWLESFLHRLSAELERDSMWQSASRYQIELAQTAVEQRLMALIYNYALYPNGDGDVSRDQVLYEHIEKLGQVVTPSHKDLRIPKIYRYECPWPSAQAELVSISAYKTPRDKVACVIRCATTIMNLLSLAAAAAERGVPAADDFMPVFVFVIIKANPPCLLSTVEYVNSFFGNRLEGEDQYWWTQFCSAIEFVKTMDYGH
The following text describes a protein:
Function:
It is involved in the activation of genes necessary for anaerobic respiration.
Subcellular Localization:
Cytoplasm.
Domain:
The cysteine cluster which is probably involved in the coordination of the [4Fe-4S] cluster is located at the C-terminal part of the protein.
Sequence:
MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDAEELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEVLVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSNSYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKRDYLRCEIECENCPLEICNID
The following text describes a protein:
Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM