lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Also plays a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA. Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling. In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation. Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein. Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Viral infection mediates TRIM26 nuclear translocation.
Sequence:
MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPISGSRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDGKLLCVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAALKKLQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELTEGREKFKSRGVGELARLALVISELEGKAQQPAAELMQDTRDFLNRYPRKKFWVGKPIARVVKKKTGEFSDKLLSLQRGLREFQGKLLRDLEYKTVSVTLDPQSASGYLQLSEDWKCVTYTSLYKSAYLHPQQFDCEPGVLGSKGFTWGKVYWEVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEEEEEEEEVLESCMVGVARDSMKRKGDLSLRPEDGVWALRLSSSGIWANTSPEAELFPALRPRRVGIALDYEGGTVTFTNAESQELIYTFTATFTRRLVPFLWLKWPGTRLLLRP
The following text describes a protein:
Function:
Functions autonomously, very early in the prespore pathway, to control prespore cell differentiation, maybe at the level of transcription. Also required for proper aggregation.
Subcellular Localization:
Nucleus.
Sequence:
MGRMKVIPEFSNYKIRTPIPIFKNELEIEKYIKGAISYIYSENTAKKLELKKRNDEIKEILNNKNDHEFVEKKIRAIVIQLGDTNLNDRCYLNYLNLYKQPIEFTHGAIMCEKNKYWVAYYASQSLNLDCLNFIIKHKDQFKGLDKDKRIKPIDPKKKISRDLLIGQPITVQCIKEDDLFKFLTVYFNQNGIEFSDSWFSSIVKLIFKGKVYSSDESEKLSTTTTTTTTPNEKYDKKILGEHTVFINKNRDGHLKFSTIPSLLLKISTLMNTGVINEYKQKNYFLETLYNSFPANKHFFNFNEETIQYITNLLLPHLHPLEFKRFNTIPWIIKSKEFIDFIIQHKDFYHLVPSIHKFTKKHENTNLFSASTINDGEEEDDDDDDNDVDGNDDDNNKEKVDDTSNKKDSIVKFKDDITIYLNVRQRFLQFSNFELANYFHTKLLECQKESENQINSNIQSINKEIESLSTSSTNTASSTRSKASSNSNQLKKKEDLEQQIIELQSLLKNKYFSNKEIYYLSFLRALKDCDISTIESIDKVVSIDSDQNNNKFQILFQKSFLENQPLKNGISPEFYDFKKVGPSSHPDVYAEGEYDEHDEYDDYQGKLDNHIDIKDSKFTKDENSRDQLFNYLKSSGFKSFTPSIFCYLLELLLLINTEKSNQQFQEIFKPISTTTTTSTTTTTTTTNLDNINEKIFKLSSDLLIHLVHIVDFKKFSIILDSVNLNRKLILEMIDNCKNKLSFQKRIYEFHDVRSKDYQYDINGHFSTNIKFSDAKDILKKLIDENLFPTSKDWIFIYHSLYISILQSTGVTLNNLLEVNKIYEEHEINYPSVLPNHSNYILDFNNNNNNNNNNNYYGLLNYQPYNNSGNINNESLKNVVSNFVLFYWFHLLDRKLSKLFVRSFSNSNFNEFSSSRLPCLKNSSICRIRSKRHSNTASQIFKSIYELQNFSLLEKYSTFKSYFPEERSYYYNNPSDPFYHPDGSKDFRVLIEEGEFQLAFNHLQLVATKTVSEFPPLTTSRLFQFITLEDVIELINLTTIKNFDESKDESEQQPLLKMWYGKDVKKCKDWILSCAIAKSRLDIVDLLLVKDIEYSTLPSTIEFLTGYKIIKSLFSPECDNQTLEYFLTFSNGIVLPSIKQYLIKDNIATQTKNDVFRVIRHGIGKFELLRTFIPSLGFSSCLIEKMVENRRFETLQYYMEIGLITNEDLTNQQKDQLKYENDLKHLDWVINLNHKKRVNRNQPTFTPNTNSTTATTATPLLQTRSGRTIIPIKK
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its not yet determined substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTLRALEPLHRACQVCNLWPWRLAPPPDSEGILLRRSRWLELYGWTVLIAATSFTVYGLFQESSVEEKQDSESTISSIGHTVDFIQLVGMRVAHLAALLEALWQRQAQRGFFAELGEIDRLLSKALRVDVEAMRINMRRQTSRRAVWILWGYAVSQLLILGAKLLSRGDRFPIYWISYLLPLLVCGLRYFQIFNATQLVRQRLDVLLVALQQLQLHQKGPAVDTVLEEQEDLEEAAMDRLIAVRLVYQRVWALVALLNRCYGLSMLMQVGNDFLAITSNCYWMFLNFRQSAASPFDILQIVASGVWSAPHLGNVLVLSLLCDRTAQCASRLALCLHQVSVDLRNESHNALVGTLVRYCAPLIILVPLQITQFSLQLLHQRLHFSAAGFFNVDCTLLYTIVGATTTYLIILIQFHMSESTIGSDSNGQ
The following text describes a protein:
Function:
Participates in iron-sulfur cluster formation (ISC) pathway for iron-sulfur (Fe-S) cluster biogenesis. Enhances cysteine desulfurase activity of IscS.
Subcellular Localization:
Mitochondrion.
Sequence:
MNGNQIKQLKKLYRHILNEASKFENINYNVYFSNKAKEKFREFCSDTNFESEKLKTFQNECWDYLNMLKRQTIIHNLYHVDKPLVNK
The following text describes a protein:
Function:
Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.
Subcellular Localization:
Nucleus.
Sequence:
MPEWPPCLSVAPALVITMAAGKGAPLSPSAENRWRLSEPELGRGCKPVLLEKTNRLGPEAAVGRAGRDVGSAELALLVAPGKPRPGKPLPPKTRGEQRQSAFTELPRMKDRQVDAQAQEREHDDPTGQPGAPQLTQNIPRGPAGSKVFSVWPSGARSEQRSAFSKPTKRPAERPELTSVFPAGESADALGELSGLLNTTDLACWGRLSTPKLLVGDLWNLQALPQNAPLCSTFLGAPTLWLEHTQAQVPPPSSSSTTSWALLPPTLTSLGLSTQNWCAKCNLSFRLTSDLVFHMRSHHKKEHAGPDPHSQKRREEALACPVCQEHFRERHHLSRHMTSHS
The following text describes a protein:
Function:
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MSPKPVADLASLKGTNCQFKFIGEGAANIVFEVVFPEEDITTQDDGDSQILDILHGKLLRVPKANTKAFPHPEILQYWESSISPLFDNPQEDLVQQYLIRLNNSVVSQLNAILENEDAQRRADFQGTKVAEAEYGMLVEDMRKKSPLDFLLEFKPKWLTPSPSAPSTATRCRNCAREAYRLHKSLRSASSDQNSSCALSHEPPFCPLEYLAAQSSPCSLARVIASMNLSAISASLDTKPATRENPVGVQPAVSLDGEDDGRPGMDQVDERYRVALVHWLQSNSLLPKLRDAQESLDPAPEGTSDQEKLALAMTLRDCTCFVRISEDSKAGLKVEAKLADLDKKNWEAKLEYWKGMDEVLKEGGYYEGVEVPRIRTRCFMEVGAGEAA
The following text describes a protein:
Function:
May be involved in extracellular digestion.
Subcellular Localization:
Secreted.
Sequence:
MQKELLTILALTLLAGTTLLNTTQSLESTSFLEDKLMKEYQLWQQEHGKRYSSFENTHRFGIFKQNYAYVQEHQKRFEAGLETYELGMNVFADISSEEFEAKHLNFKPSNKQQSEQVFRAQGRQIPESVDLRNDGVVGPVQNQGSCGSCWAFSAVGALETAARQSGEKNVEFSEQELVDCVKGGEYESDGCNGGFMFESFNYATTNGIAIKSEYPYVAVAQDCQAKKTKTRFQFNGFVEVESLNSQAYVEAASQHALSVGVNAKGINFQLYKKGIFSSQCDGKIESLNHAILNVGYASDYYLLKNSWGLSWGEAGFIRFARIANKTGQCGVHQDVTYPIYNKNSAAIQ
The following text describes a protein:
Function:
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
Miscellaneous:
MISCELLANEOUS: Enterobacteriaceae carrying this gene (identified by PCR) have been isolated in Sweden, India, Pakistan, Bangladesh, England, Scotland, Northern Ireland, Australia and the USA. The organisms they were identified in were K.pneumoniae, Enterobacter cloacae, E.coli, Proteus spp, Citrobacter freundii, Morganella morganii, Providencia spp and Klebsille oxytoca. In India most isolates were from community-acquired infections rather than hospital-acquired infections, indicating the gene is widespread in the environment.
Subcellular Localization:
Periplasm.
Sequence:
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MSSIKSYTIGNELGRGSFATVYKGEHVASGSPVAIKSVLRAKLNRKLLENLGSEISILKQMKHPHVVELLDFQETPTHFHLVMEYCSLGDLSFFLKKKKELSETLPLVASLLRRYPSNTRGLHEELVRHFVHQLSAALEFLRQKNLVHRDIKPQNLLLCPPSLSEMDAQNANLYGRWELPILKIADFGFARILPASALAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVTYEMVVGKPPFKANNYVELLKTIEQSNDVIGFGREPPSEDMQDFVRCLLKKNPADRIGFKEYFEHPIIANKQVIGSGEELDRSQLDPRMYISEYIQEADLPKLDLDREMDSFSQKRSTQKSSPKNSTNKTLSSTVKNPLLELTSPSPGSSLLLTRKNESLFLESEYVVVEKRQVEVNTLADELAREPDERRPSSERRFSLTYGAPTGAMARALSMASARLLGEKKNGAGHGSGNGSRNGSGNGSGNGARLSAGAALSGTSSGTSTTGKSPPVPATTTPSLSEREIVETLEEIAAKARSIALLADVKYSQIQDDVDNPDMNLPDSVSSSIAEEAMLLYVKTLSLLSLAMDQAGAWWSNNHKDNKMVSSHFNEIIQWTRSAFNESLERAETVKKKVSSGTTHTTAEKLIFDRALEMSRDAAVQEISGDFTGCESAYTTSIWMLEALLEDDEDGLGEEDRRIVERFISSITKRLVILRGQQE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLSHVDLIEKLLNYAPLEK
The following text describes a protein:
Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPYLPPPCPPEHCPPPPCQDKCPPVQPYPPCQQKYPPKSK
The following text describes a protein:
Function:
Growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor.
Subcellular Localization:
Secreted.
Sequence:
MAPGRVLLCSLLLLSLQLGLGWGPGVRGAPVVEGELRGTQRPQLGGRPRRALASPCQLWSLSLPVAELGLGYASEETVTFRYCAGSCPRGARTQHGLTLAWLRGQGRALGGPCCRPTRYADVAFLDDRHRWQRLPQLSAAACSCG
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MSIRLYSKQSLNTFKKATFIPLTTTATAITTTQFRYFHDTPNKQNVTVNNMMPRVTKPTPTNTFTTSPQLPSTEYLKAFNNKELISFFMIGLATLNKPILQLCIKLFPYVPMSIIKALVYRIYCGGETIDQVKKTGLRLHERGINNMMISLTIEACDGNDNVDPKYIVEETAKSIETILVPHTVAMIEQATDDINDIPPGYVALKPTGFAKDAANVLKNYNTTMIKEFDELVDKAIIVCQKIYDSNKELSQKYPERVSPFVVGVIDAEKHELQEGVYELQRRLYQKFNKLNQPISIVGTLQMYLSDSANLLTKEENLANENNYRLGLKLVRGAYIHSEKNRDIVIHKTKQDTDNNYNSGISYCIDSILNQNQNQNGSTIGHLVVASHNAESMRLASDKVYNPMNESNKNKTNVVLGQLLGMADNVTYDLITNNKIGNVIKYVPWGPPLETKEYLLRRLEENGDAVKNDNGWPLVKASFKMLTKRLFGSG
The following text describes a protein:
Function:
Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Midbody.
Sequence:
MAEEDERFDGMLLAMAQQHDGGVQELVNTFFSFLRRKTDFFTGGEPGAPEKLVKEAFAHHNQLAQKAQREKRAKQEKERREKAERAARLAEEEEEGKEKKTGEQNEPKIKELTDEEAAQLQSEIDQKKEEAKKQESAPKNDAENSSDKVEDKGSDSEGEEDEKDKGKLKPNSGNGADLPNYRWTQTLSEVDLLVPFDVKFRLKGKDLVVDIQRRHLKVGLKGHPPVIDADLYNEVKVEESSWLIEDGKIVTVHLEKINKMEWWSKIVTTDPELNTKKICPENSKLSDLDGETRSMVEKMMYDQRQKSMGLPTSDEQKKQDILKKFMAQHPEMDFSKAKFS
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MLTGQESLLRLIGKRRRCLPNRHNLLSTPTPNSLNLDVNDSGNLISPTGDNIRSPETPPTYPGNSDDLSVSRKNKKKRRLTQTTLLQWSGSKQSQHSPLIHPPKQQQSILEFDDDSSSEEISKTVALDEANGDEAIQTFIVGRKFSDVQDLEAGEKICLLRHPENIKDPNAIKVLSSDSGLSEILGYLPKDVSQCLSPLIDQYDLKFEGTINSVPKNSSEAVSVKVVCRKMTSDGWKESESAGGDFKLMWEKVLQVVEHQMLFPPKTTRYQLNFNVLVQEVLRSCSHLFTADEKAFLESFTSLSEDSQRLFIRLYTRKGPWFRLSNISYPEVSDSLQALKDLTVKGFMTSVENANDLNYQTMKEIIELLNVTELRDILSVNKVFSRGSRKRDLINSLCSYYNDGTRINVGTMILERTGLCAKISSTSESLIWRVERLFFLNGEQDLSSFVLLDLGIIKYPIYKCIDSEQIFSDRTKLLAYEEVFYLSILLKQKKHVCLYSISKLQLQAIEVAQLMDESLDCEDSGTVLKCIMIAETRISSSSSSESALFNCFTAPWVYSKMVLLGVSFLENQKRHVENKPSPLLLTCSDDSVDTLVSGFRYNQAVYLLRRLLSCFSCDGRRGYWTVRLSTDLEHMGRPNESLSVAEQGLLDPWVRAGSRIALQRRILRLAKPPRRWKTPTFPNLVDNKIPEVTIQGRSLNCEVGMKNRFYGEDGEQCGVEQLALQYYNGEGGGWQGMHTESSIWLTIFGLLMWDILFSDVPGVFQTRFQTAPLDLETESFYQTRKETIEAQLEKVASGMAEEILIISYETHRGTACRGVAWERFSLEELRAAVACVGGKCVASLCRYLAQDYRSWCSGMPDLLLWRFKENGYEGEAKLVEVKSEKDRLSEQQRAWLLLLMDSGFNVEICKVRPACV
The following text describes a protein:
Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein.
Sequence:
MLKLADMRKTVFLTTNYFESSLKPLFAPRSLQGRFLYTNFPEEESLGLPFFMDGSYRITNLPGLKGFLIFWNENNIQFSHNSGQLVGPIIVKKNMQFLYPSISQMGMKIYTIASYDNELAILTENGRFFYGTLGLLSTSIFEVTPEDIDINNTALMFIGVGFIFVVTPIKDPVFQAYDFHICIINIQKLLQQSEIGLKTCKAELLQGNFDKTMHILDMSDTLHLYGVMVPQPTQNPIPIITISNPHSLGLKLKMYEDGYTYDGNIKFKINITLMQQYLSGKAHDSFISNIKVPSLSTITLDLIDRGLSCIDLQPPTGLISIGCNWAKKIIIRNTLNACTKDILTPVELQKNYTYILEKGTYDPSFNSRLRLDLQDQAVIYDYEELGCPQLVYFNNPWKPVIELWEGSRFVEVVTTEFVLMEKNGMHTYNYSKNVGGANCKSQAQNWTSVMAASTTKNYLAWTREIYVTCHELNHSIPLLWPDLEYQILGGRTDNSIIFQERNGFYIFHLTIVDPFYSYCDLTTSFAIYVYGAFPQRLLPDYPLALLVMLSMLFILWLGYVIPKLSSTEKGRVIIGFFQELWNPFMKREKRKRPSHR
The following text describes a protein:
Function:
Involved in intron recognition and spliceosome assembly. Binds to multiple 5'-GAAG-3' repeats found in its third intron, suggesting autoregulation of alternative splicing. May be necessary for accurate splicing of the 3' region of introns.
Miscellaneous:
MISCELLANEOUS: The splicing pattern of the pre-mRNA is regulated in a tissue-specific manner and by development, and changes in response to various types of abiotic stresses and hormones.
Subcellular Localization:
Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm. Note=Colocalizes with spliceosome components. Follows a dynamic subcellular location during the cell cycle. Distributed throughout the cell on entry into mitosis, as the nuclear envelope breaks down. In metaphase, diffusely present throughout the cytoplasm. In later telophase, as the nuclear envelope is reformed, reenters into the daughter nuclei where speckles are observed. Daughter nuclei acquire later a typical interphase spherical shape and the nucleolus gradually forms.
Sequence:
MRGRSYTPSPPRGYGRRGRSPSPRGRYGGRSRDLPTSLLVRNLRHDCRQEDLRKSFEQFGPVKDIYLPRDYYTGDPRGFGFVQFMDPADAADAKHHMDGYLLLGRELTVVFAEENRKKPTEMRARERGGGRFRDRRRTPPRYYSRSRSPPPRRGRSRSRSGDYYSPPPRRHHPRSISPREERYDGRRSYSRSPASDGSRGRSLTPVRGKSRSLSPSPRRSISRSPRRSRSPSPKRNRSVSPRRSISRSPRRSRSPRRSRRSYTPEPARSRSQSPHGGQYDEDRSPSQ
The following text describes a protein:
Function:
Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue.
Subcellular Localization:
Mitochondrion.
Sequence:
MRTAAMLCLTKLYPSWKTWASGNQLKFLHPWNGGIVIQAVGKKDYFDLLDLDEKDLEEQFVRGHGPGGQATNKTSNCVVLKHIPSGIVVKCHQTRSAELNRKKAREILQEKIDIFYKGENSDILKQKEDGERKKQEKKKKAKELLEKKKQLKEMQYPETK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MHFLSPAKLNLFLQILGRREDDFHEIVTRYQAIAFGDQLSLSISSRDSLQVINACHLETPSNSIWKSVALFRRYTGITTPVSWRVVKQIPVGAGLAGGSSNAATALFALNQIFKTGLSDEEMRSLAEQLGVDTPFFFSTGAALGVARGEKIIALEESVSDRYVLYFSSEGVLTSRAFAAVQPSDCSSRKNLEYTQNDLEKPVFRLRLDLKEKKHWLENLWAELPVHIGLTGSGATLFVRYPEILEEDLSYAAQIQRAVTLSGGLLTSPIRRDPTAWYSIYSESALAAT
The following text describes a protein:
Function:
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Functions as an inhibitory receptor in NK cells and T-cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation.
Sequence:
MSPHPTALLGLVLCLAQTIHTQEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHLYILIGVSVVFLFCLLLLVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSALAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARH
The following text describes a protein:
Function:
Negative regulator of Ras-cAMP pathway. Involved in transcriptional regulation of galactose-inducible genes.
Subcellular Localization:
Nucleus.
Sequence:
MSREAFDVPNIGTNKFLKVTPNLFTPERLNLFDDVELYLTLIKASKCVEQGERLHNISWRILNKAVLKEHNINRSKKRDGVKNIYYVLNPNNKQPIKPKQAAVKQPPLQKANLPPTTAKQNVLTRPMTSPAIAQGAHDRSLDNPNSTNNDVKNDVAPNRQFSKSTTSGLFSNFADKYQKMKNVNHVANKEEPQTIITGFDTSTVITKKPLQSRRSRSPFQHIGDMNMNCIDNETSKSTSPTLENMGSRKSSFPQKESLFGRPRSYKNDQNGQLSLSKTSSRKGKNKIFFSSEDEDSDWDSVSNDSEFYADEDDEEYDDYNEEEADQYYRRQWDKLLFAKNQQNLDSTKSSVSSANTINSNTSHDPVRKSLLSGLFLSEANSNSNNHNTAHSEYASKHVSPTPQSSHSNIGPQPQQNPPSANGIKQQKPSLKTSNVTALASLSPPQPSNNERLSMDIQKDFKTDNESNHLYESNAPLTAQTILPTALSTHMFLPNNIHQQRMAIATGSNTRHRFSRRQSMDIPSKNRNTGFLKTRMEISEEEKMVRTISRLDNTSIANSNGNGNDDTSNQRTEALGRKTSNGGRI
The following text describes a protein:
Function:
Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).
Subcellular Localization:
Cytoplasm.
Sequence:
MAFAMKVISQVEAQRKILEEAVSTALELASGKSDGAEVAVSKTTGISVSTRYGEVENVEFNSDGALGITVYHQNRKGSASSTDLSPQAIARTVQAALDIARYTSPDPCAGVADKELLAFDAPDLDLFHPAEVTPDEAIELAARAEQASLKADKRITNTEGGSFNSHYGIKVFGNSHGMLQGYCSTRHSLSSCVIAEENGDMERDYAYTIGRAMADLQAPEWVGAECARRTLSRLSPRKLSTMKAPVIFANEVATGLFGHLVGAIAGGAVYRKSTFLLDSLGKQILPEWLTIEEHPHLLKGLASSPFDSEGVRTERRDIVKDGVLTQWLLTNYSARKLGLKSTGHAGGIHNWRIAGQGLNFEQLLKEMGTGLVVTELMGQGVSGITGDYSRGAAGFWVENGEIQYPVSEITIAGNLKEMWRNIVTVGDDIETRSNIQCGSVLLPEMKIAGQ
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MAAAALAVTDELALPLRAVGDLAAAAGISREEVVVITQCATLGGKLPFDDASVGAVLSVIKKAESFGDQLVAEVSRVLKAGGIVLVQSFTPSSEQKPNNYIERQLLMGGFVEVQTSATSSQDSVQSVTIKAKKPSWSMGSSFPLKKATKALPKIQIDDDDELIDEDSLLTAEDLKKPQLPVVGDCEVGAAKKACKNCTCGRAEAEQKVEKLELTAEQINNPVSSCGSCGLGDAFRCSTCPYRGLAPFKLGEKVSLSDNFLSADI
The following text describes a protein:
Function:
Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
Sequence:
MFHLIRWQDIADIIIMSFLAYRLYSWFRHTRAMQVLIGLGILAGVYFVTRNLGLFMTSWILQELGTVLFVLIIVVFQAEIRQALYRFSLLRTFIGRQEGGGELDLAELGRTVFGLARERTGALIVLQRQEALDDYLLHGVKVDGLPSSHLLGSIFRNGTPLHDGAVIIKDGRVSQASCHLPLSMKTELPQNFGTRHRAGIGLSERSDAVVIIVSEERGEVGMALAGEYRKIASPEEFAEVIQGLLYPQRPENVAFTLRQRLLRNLVPKIVTTLIVIAGWLVVTTKEGGIFTVTVPIKFHNLPPRSVLVKSVPESVEVQLKVFTSLIPSPRQLDLVADLNLAGVHDGVNSLAVKDDDLNLPLGVVVTGINPPMVKVTIAGKERKQLRVRPKLTGQLPGRAKLRSVTADPDTVVVEGPGHLLEGLESLPTETVDLAGLRRGGVVERRVVSPSPQIRVLRDEPVRVVVVTSVK