lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
Subcellular Localization:
Cell membrane. Cell projection, bleb. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MSTGDNFESRCGRIDGILRDPKSEVNTDCLLDGLDAMVYDLDFPAMRKNKNIDNFLNRYKDTMSKVRDLRMKADDYEVVKVIGRGAFGEVQLVRHKSSRKVYAMKLLSKLEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNREGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPEDSDISKEAKNLICAFLTDREVRLGRNGVEEIKRHPFFKNDQWAWETLRDTVAPVVPDLTSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRQYLDDPSANPNDNRSSSTVDKNLVENLQKNIYQLEEQLHNEMQLKDEMEQKCRMSNIKLDKIMKELDEEGNQRKNLESLVAQTEKEKIMLQHRINEYQRKAEQESEKRRNVENEVSTLKDQLEDFKKISQTSHITNEKIAQLQKQLEEANDLLRTESDTAVRLRKSQTEMSKTVSQLEALNRELQDRCRLLESSKSQVEKDYFHLQAALDSERRDRSQGSEMIGDLQARMASLQEELKHVKNNLEMAESERKRAQDLLNNSEKEKNNLEIDLNYQLKTLQQMLEQEINEHKVTKARLSDRHQSFEEEKSVAMCEMEMKVKGERAAKEKAENRRVEIEKQCSMLEFDLKQSRQKMEHFTQQRERLEEEVKQLTLQLEHETKKRIVTQNELNQHAGLVDTLKGSEKQLKQEINTLLEAKRLLEFELGQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVRELKEEVEEKTKHSHELEKRVHELYNDKDTLTAQLDLAETKAESEQLARTLLEEQYFEVNQENKKLSARSWQDNTEKDHTIRKLEETNSTLTKDVQTLTKANEELSEKARKLEQEYKEKEEEIYNLRNSYEKAINTEKTLKTQAVNKLAEIMNRKDFKLDRKKANTQDLRKKEKENRKLQLDLNQEKEKYNQMVAKYQKELDETLMQLTEESNYKNELQMQLDSKESDIEQLRARLADLQLRMDSTSVASLQPDDTDGIIGESRIEGWLSIPNRGNIKRYGWKKQYVVVSSKKILFYNDEQNKEQSSPSMVLDIDKLFHVRAVTQGDVYRANTEEIPRIFQILYANEGECRKDVELEPVQQTEKTNFLNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHKDHLDKKEELISPCKVSYDVTSARDMLLLACTQEEQTKWVSHLVKKIPKTPPPTLVRGNQRTMSTRSSTNQSFRKPAKTSSGKAS
The following text describes a protein:
Function:
Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity).
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MKRFISTTSLRVLSNLNKNNNNNNKFNKSIVGVFNREFSSSNEGLNKVNFGENNNSSTTEPTKVLFNDSQFYQEDKYQGISKEPFSKEIVDTLLADLNPDDIEIKPDGLIYLPEIKYRRILNQAFGPGGWALKPFGPPVVEGKTLIRPYALYCLGRYVAESIGEQQYVPNSFISFATATESAKSNALVRCCKDLGIGSSLWDPIFIRQWKSEYATERWCENSKTKERRLFWFLSNRSENQLPYPWKESDFNQVPSNSSYSSSSSSINNNSNSSNNNNNNSDSSSSINQPQQETISYHQDDSSSPSSKITEQQDDSEDIDIDDVVPPQLKKYAGKTWRQLVADPKGLSYLQWASSSFDNAPKIKSQATAILEFINKSQ
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Sequence:
MTTWARQSAVFVSKVTDPWINLAFEDWLFNTQKQFKYQLMLYRNVSSVIVGRNQLYTLTIITKNPWRECSVLALDRDNIPIIRRKSGGGTDMGNTNYSIMMPRDEFDRKRNAHLVSRALHQMDVPSQVNARHDIVIGDRKVSGSAFKLVNHRAYHHGTMLISTDISKLGAYLKGPEQGQIVGRGVESVKSQVTSLLNHSYTADHDGFCKCVAQEFEMEYSENPIPATFLTMDDFHASKEVQDIYHTLKSWEWTFGETSQFVHTIPSGQAEKNIAITVLEGIITDVQLIHRASSDPHADSRTAQWIGKRYDANMPLCIQQSLF
The following text describes a protein:
Function:
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Nucleus. Mitochondrion intermembrane space.
Sequence:
MDIAEVTEVLEEESLAVSTSSTAEAEFDAVVGSREDMIMDAEFQVLKRNFMDRYYQEFKNTEENKLTYPAIFNKNLSFIEKYIENQLLERIPGYNMAIFTRTLKHHNDEMVHDVFNMLTCTDFPAFKEMFLEYRTEKEGRRLDLCSGLVVTSLCKSASQNNTKHHLLRPGSGSLLIP
The following text describes a protein:
Function:
Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles in regulating response to jasmonate, and their interactions with the COP9 signalosome (CSN) appear to be important for their activity. Interacts with TIFY10A and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor. Involved in the regulation of plant gene expression during plant-pathogen interactions with Pseudomonas syringae and Alternaria brassicicola.
Domain:
The F-box domain is essential for the formation of SFC(COI1) complexes; The Leu-rich domain is involved in the interactions with RBCS-1B and RPD3B.
Sequence:
MEDPDIKRCKLSCVATVDDVIEQVMTYITDPKDRDSASLVCRRWFKIDSETREHVTMALCYTATPDRLSRRFPNLRSLKLKGKPRAAMFNLIPENWGGYVTPWVTEISNNLRQLKSVHFRRMIVSDLDLDRLAKARADDLETLKLDKCSGFTTDGLLSIVTHCRKIKTLLMEESSFSEKDGKWLHELAQHNTSLEVLNFYMTEFAKISPKDLETIARNCRSLVSVKVGDFEILELVGFFKAAANLEEFCGGSLNEDIGMPEKYMNLVFPRKLCRLGLSYMGPNEMPILFPFAAQIRKLDLLYALLETEDHCTLIQKCPNLEVLETRNVIGDRGLEVLAQYCKQLKRLRIERGADEQGMEDEEGLVSQRGLIALAQGCQELEYMAVYVSDITNESLESIGTYLKNLCDFRLVLLDREERITDLPLDNGVRSLLIGCKKLRRFAFYLRQGGLTDLGLSYIGQYSPNVRWMLLGYVGESDEGLMEFSRGCPNLQKLEMRGCCFSERAIAAAVTKLPSLRYLWVQGYRASMTGQDLMQMARPYWNIELIPSRRVPEVNQQGEIREMEHPAHILAYYSLAGQRTDCPTTVRVLKEPI
The following text describes a protein:
Function:
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.
Subcellular Localization:
Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
Sequence:
MSWAKQRVPFLDDDDGEEENDVQDDVDSPVPTRPLVIDEDAEPAAGTSGGLEGGGGDDEDGEDGHALPDLDDDLLLQFEPMLPRVYDLLLPSLDARLNFVNAGQKYAAFLKYVHGDCATCSHGEILREKTQLLTAIVSKLMDINGILEGKDESAPGK
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MSIARIFGMGLRNKRVSTTAFRYNANRNSKVQLRSIVRYRHSSPSQEFETNSAEIRVNSTTITIKQPDEDDLQYDHFYLFDHCRCPQCFHPRTKQRLKTLSQIPSDIHPTAVALSRSGLHITWSTPSAHTSFFPAGFLRRAAYETQLSEHVDCRDDRTLWNSEISKSPPYVAYDDIMSQQVHQHEQAVLQVLNKVHQFGFCFVTGVPIDAKETETLIKSIGPIRQTHYGGFWSFTADLSHGDLAYSAQSLPAHTDTTYFTDPAGLQIFHLLSHPSPGQGGKTLLADGFHAASQLSAVDPASYSVLSRLPIPAHASGTKGTLLRPLISFPVLRHDECGRLAQVRWNNEDRGIIGHGWSATEVRQWYQAAQRFESLVKSEQNEYWVQLNPGTMLIIDNWRVMHGRSEFTGSRTMCGAYIGADDWYSRRAVLTERHGDVGGMDDVWRFGW
The following text describes a protein:
Function:
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation.
Subcellular Localization:
Cytoplasm.
Sequence:
MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADTYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHNDRNWQRNRPWPKDSY
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MGREREREVQQYTVEQLVAVNPYNPDILPDLENYVNDQVSSKTYSLAANLCLLRLYQFEPERMSTQIVSRILVKALMAMPAPDFSLCLFLIPERVQMEEQFKTLIVLSHYLETGRFRQFWDEAAKNRHIVEVVPGFEQEIQAYAIHVLSVTYQKVPRAVLAEAINIEGLSLDKFLEHYVANSGWILEKSHGRGQLIVLPRNEFNHPELKKNTEDSVPLEHITRIFPILG
The following text describes a protein:
Function:
Functions as a zinc transporter.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MASNLPIPRPPRTPTPPPDDPTSVTDGQPLRGFAATYDKDTLSPMVDHFSQNGLNVEDGDRLSPTRSSFKLSPTDVSVQSGASDNGSAGPFNFQTTTMAKGPVMKSNIGQRRGHKYKHSSISHQIFLEPPPRAPLALPNSLPIPTLKECRSSMSKDQKTRFWWSVCHMFVAAYTLWSAHGSLAMTALSHLILFDSLGALLCVAVDVLSNFEVWKRSSIRHPFGLERAEVLAGFAMCVLLLFMGMDLISHNLQHFLESSDNHEPHHTHPHERVSVGSVDITAVLAISSTLISAIGLKNHARIGKAMRFAYIESLPSVLSNPSHFLTLSCSTLLLLLPLVSIKLYKWLDVLLSVTISISMCVLGVRLVKTLGSMLLMSYSGPGVSDVIKDIEADPSVFGIDDARFWQVHYGLCMANLKIRVSGSEENLVRLRERISSLIKNRLGGGYGTGGQKWEVSLQFTVDNS
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MTDILSPLAYLCGKPTAKAKLKALPEHFQVNEVLGYSLTGHGEHLMVRIRKTGENTSFVANELAKACGVPSRAVSWAGLKDRHAVTEQWLSVHLPNGETPDFSAFLAQYPSIEILEVTRHDKKLRPGDLQGNEFVVTLSEVSDVAAVLSRLETVAELGVPNYFGSQRFGRHGNNLSEARRWGRDNVRSRNQNQRSLYLSAARSWIFNQIVSKRIEQGCFARFIEGDIALAEQQMFNVDGDLALWDQRLQAGEVAISAALAGDNALPTSGQALPLEQAELDAEPDLMALIRGNRMRHDRRAIALKAQNLSWQVQEDQITLRFSLDAGSFATSLVRELIEEIPVVRHYDQGHEQESRDSESED
The following text describes a protein:
Function:
Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSFQNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQNQINYQALVERMNGKFNSLKTVLTGGK
The following text describes a protein:
Function:
Involved in the regulation of cellular calcium homeotasis. Required for spermatogenesis. Acts as a regulator of STING-mediated inflammatory signaling in macrophages. Forms a complex with STING, promoting the activity of TBK1 kinase and the transcription factor IRF3, leading to activation of type I interferon expression.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment. Lysosome membrane; Multi-pass membrane protein. Note=Co-localizes with STING1 in the lysosome membrane, mediates lysosomal localization of STING1.
Sequence:
MLFSLRELVQWLGFATFEIFVHLLALLVFSVLLALRVDGLTPGLSWWNVFVPFFAADGLSTYFTTIVSVRLFQDGEKRLAVLRLFWVLTVLSLKFVFEMLLCQKLVEQTRELWFGLITSPVFILLQLLMIRACRVN
The following text describes a protein:
Function:
A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
Subcellular Localization:
Cytoplasm. Note=Associates with ribosomes and polysomes.
Domain:
The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA; The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.
Sequence:
MADDKKIIFSMVGVSKAFQPNKNVLKDIYLSFFYGAKIGIIGLNGSGKSTLLKIIAGLEKSYQGEVVFSPGYSVGYLAQEPYLDDTKTVKEVVMEGVQPIVDALAEYEEINQKFGLPEYYEDQDKMDILFARQGELQDIIDATDAWNLDSKLERAMDALRCPPEDQPVVNLSGGERRRVALCRLLLQKPDILLLDEPTNHLDAESIDWLEQHLQQYEGTVIAVTHDRYFLDHVAGWILELDRGEGIPWKGNYSSWLEQKTKRMEMEEKTASKRRKTLERELEWVRMAPKARQAKGKARLNSYDKLLNEDLKEKEEKLEIFIPNGPRLGNKVIEAKHVAKAYGDKLLFDDLNFMLPPNGIVGVIGPNGAGKTTLFRLIMGLETVDKGEFEVGETVKVSYVDQQHKDIDPNKSVYQVISGGNDLIRMGGRDINARAYLSRFNFAGADQEKLCGVLSGGERNRLHLAIALKEEGNVLLLDEPTNDIDVNTLRALEEGLEDFAGCAVVISHDRWFLDRICTHILAFEGDSNVFYFEGSYSEYEENKLKRLGNEEPKRVRYRNLMTD
The following text describes a protein:
Function:
Plasma membrane sugar-proton symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNSSGVEQGVVIAESEPPRGNRSRYAFACAILASMTSIILGYDIGVMSGASIFIKDDLKLSDVQLEILMGILNIYSLVGSGAAGRTSDWLGRRYTIVLAGAFFFCGALLMGFATNYPFIMVGRFVAGIGVGYAMMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYFFSKLPEHLGWRFMLGVGAVPSVFLAIGVLAMPESPRWLVLQGRLGDAFKVLDKTSNTKEEAISRLDDIKRAVGIPDDMTDDVIVVPNKKSAGKGVWKDLLVRPTPSVRHILIACLGIHFAQQASGIDAVVLYSPTIFSKAGLKSKNDQLLATVAVGVVKTLFIVVGTCVVDRFGRRALLLTSMGGMFLSLTALGTSLTVINRNPGQTLKWAIGLAVTTVMTFVATFSIGAGPVTWVYCSEIFPVRLRAQGASLGVMLNRLMSGIIGMTFLSLSKGLTIGGAFLLFAGVAAAAWVFFFTFLPETRGIPLEEMETLFGSYTANKKNNSMSKDNEVVDGQ
The following text describes a protein:
Function:
Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Seems dispensable for proper chromosome segregation.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Chromosome, centromere. Note=Localizes at the centromeres during interphase, but not in mitosis.
Sequence:
MLEQSESHAFINNAPKEDRIQVKFEQLFESLPLPLRAEEALSKLRHDSARLMILKTSDPTLNMSTYSIEDSPMGFECLKYNLSDNNKLLSQNNYRLPDYLEEDEIVSYTFSKTGPTTSKNKHPSHSNTIRSPPYKVKKESCHTEINNVSNVSTESINVIDASRGYSPYTSVDSLSVSKNRSFISLEESASNQYDAAEAFYFNADSSSPLRKLSPIELPVTPIRRKTPTINPNSELKRLQTFGKLILHKGSRRR
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWDPSETTLYSMMMFLFMETILEMYLTRRQISVYKQCKTVPRELQHVMNSDTFEKARVYGLDKAHYGMFKMIVCDIVILQLELYFGFMAMVWARSVEIAENIGLNPKSEIQVGCLFSLILNIIGIFKEMPFKIYGTFVLEEKHGFNKQTAGFFVKDQIKAFVVAQALTIPVAAAFIYIVQIGGQYFFIWLWAFVAVVSLVLITIYPVYIAPIFDKFRPLEDGELKKSIHDLASSVKFPLGQLFVVEGSKRSAHSNAYFTGLFGVKRIVLFDTLLVNKGLPADDPSLSESDKGKGCKNEEVLAVLAHELGHWKLGHVAKNIVIMQLQMFLIFLAFSKLFTYGPLYEAVGLPAGEKPILIGFMVIVMYVLAPYNTMISLAMTIMSRRFEYQADGFAQELGYADELGNALIKLQLDNLGFPVYDWMYSAWNHSHPTVLQRLERLKSLNKEGHKSKTQ
The following text describes a protein:
Function:
Involved in the naphthalene catabolic pathway. Catalyzes the reversible glutathione-dependent isomerization of 2-hydroxychromene-2-carboxylate (HCCA) to trans-O-hydroxybenzylidenepyruvate (THBPA).
Sequence:
MIVDFYFDFLSPFSYLANQRLSKLAQDYGLTIRYNAIDLARVKIAIGNVGPSNRDLKVKLDYLKVDLQRWAQLYGIPLVFPANYNSRRMNIGFYYSGAEAQAAAYVNVVFNAVWGEGIAPDLESLPALVSEKLGWDRSAFEHFLSSNAATERYDEQTHAAIERKVFGVPTMFLGDEMWWGNDRLFMLESAMGRLCRQNADLSS
The following text describes a protein:
Function:
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKTYKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSISFSYNTGDNTTFPDAEDKGILTVDELLAIKIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNGTVSTNEFLCDKDKTSTVAPTVHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQLNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVNISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQGKYSTAEECSADSDLNFLIPVAVGVALGFLIIVVFISYMIGRRKSRTGYQSV
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MIEPMPAMKKSAVHGGIGHVFNKLTSEIGDPVDFELPDWLNKWQPTPFTYIKRNIYLTKKVKRRLEDDGIFCSCSSTAGSSDVCGRDCLCSILWSSCSSGCKCGSACLNKPFHQRPVKKMKIVMTEKCGSGIEAGEDIKRKDFVIEYVGEVIDDKTCEERLWKMKHSGETNFYLCEINRDMVIDATYKGNKSRYINHSCCPNTEMQKWLMDGETRIGIFATRDIKKGEHLTYDYQFVQFGADQDCHCGAVKCRRKLGIKPKKRKLSSSDAALKLVACQVAASSPKVKALLSLKHGCQTGVPPKVG
The following text describes a protein:
Function:
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAARCLRWGLNRAGAWLLPSPTRYPRRALHKQVEGTEFQSIYSLDKLYPESRGSDTAWRLPDDAKQANDIPVDRLTISYCRSSGPGGQNVNKVNSKAEVRFHLASADWIAEPVRLKLAVKHKNRINRSGELILTSECSRYQFRNLADCLQKLRDMIAEASQPAKEPSREDAELRRSRIENMNRERLRKKRISSAIKTSRRVDVD
The following text describes a protein:
Function:
Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing OFP16 show small rosette size, late flowering, reduced fertilization and blunt-end siliques.
Subcellular Localization:
Nucleus.
Sequence:
MPKILWKSLHLCFPSNLTKCYSSPCIPPSSADPDGIIQPNRPSIVLLNNFNLLYHNDNHHHPHRVIDLPSSSTTTTPAATSSSSTSSYESDISPDVSAAFASRRFFFSSPGRSNAITDSPEPRSREFSDNYDDATITSTKKKKKKVYDNSVTTTTTRLISGGTAVTQHVDSPDPLTDFRRSMQEMIDAAIDAGELSRDPNDGYDFLDELLLTYLSLNPADTHKFVIRAFSDILVSLLSEERRIC
The following text describes a protein:
Function:
Recombinational reparation of DNA damages induced by UV and gamma radiation.
Subcellular Localization:
Nucleus.
Sequence:
MFQAETVCLKQIQSTLRCIDFSKECTIEITSRGLRFAVEESQSLQAHAFLDKSLFQTFNFQGDSDGDTYMFQTMISPLLQSLSIYTDGKERISTSAWDQPTVNIMHKRGVICKVQYNGPGCPFIWEVEEMAGYATACELLTMECEDDVDINRLASTLCTKIIMKSNWLYDALVELDNNMGENLIIHTSSQKSTFLLRCVGALSTTEIEYPNEKSVLESFETDSENTYSYRFSLIRHALKALQVGSKVNLRIDENGTLSIQIMLVGQEGLCTFVDFCIVPLDLVSEDEEEDEEEEPAESNQSDNNVLRNDPNYRGDAETEDEDS
The following text describes a protein:
Function:
Fatty acid desaturase involved in the production of chloroplast-specific phosphatidylglycerol molecular species containing 16:1(3E). Catalyzes the formation of a trans double bond introduced close to the carboxyl group of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Domain:
The histidine box domains are involved in binding the catalytic metal ions.
Sequence:
MAVSLPTKYPLRPITNIPKSHRPSLLRVRVTCSVTTTKPQPNREKLLVEQRTVNLPLSNDQSLQSTKPRPNREKLVVEQRLASPPLSNDPTLKSTWTHRLWVAAGCTTLFVSLAKSVIGGFDSHLCLEPALAGYAGYILADLGSGVYHWAIDNYGDESTPVVGTQIEAFQGHHKWPWTITRRQFANNLHALAQVITFTVLPLDLAFNDPVFHGFVCTFAFCILFSQQFHAWAHGTKSKLPPLVVALQDMGLLVSRRQHAEHHRAPYNNNYCIVSGAWNNVLDESKVFEALEMVFYFQLGVRPRSWSEPNSDWIEETEISNNQA
The following text describes a protein:
Function:
Needed for flagellar regrowth and assembly.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSSNRSDNQLDDKLSHRVVSDAEIEFSHWQLPDVTETEDVSISNLFGYSAQQAPKAVAVETVAPPTMAEIEDIRAQAEEEGFNEGKTQGHIEGLEQGRLEGLEQGHKEGFTQGHEQGLETGLAEAKALLSRFEGLLCQFEKPLQLLDGDIEHTLMSLTMALAKSVIGHELKTHPEQILSALRLGVESLPIKEQTVNLRMHPDDVTLVETLYSSTQLTRNQWQLEADPSLTAGDCIISSQRSLVDLTLSSRIDAVFESLRNQQSHLALQQQQRQAALDEENAAKIVPESIKDADELVAQYQGDGEQDAQSPPSTAE
The following text describes a protein:
Function:
Cell wall protein which plays an anti-adhesive role and promotes dispersal of yeast forms, which allows the organism to seek new sites for colonization.
Subcellular Localization:
Secreted. Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=In yeast cultures, is linked covalently to glucans of the wall matrix, but, as cultures approach stationary phase, accumulates in the medium and is extractable from cells with disulfide-reducing agents. Removed from the cell wall by proteolytic cleavage by SAP9 and SAP10.
Sequence:
MKVSTIFAAASALFAATTTLAQDVACLVDNQQVAVVDLDTGVCPFTIPASLAAFFTFVSLEEYNVQFYYTIVNNVRYNTDIRNAGKVINVPARNLYGAGAVPFFQVHLEKQLEANSTAAIRRRLMGETPIVKRDQIDDFIASIENTEGTALEGSTLEVVDYVPGSSSASPSGSASPSGSESGSGSDSATIRSTTVVSSSSCESSGDSAATATGANGESTVTEQNTVVVTITSCHNDACHATTVPATASIGVTTVHGTETIFTTYCPLSSYETVESTKVITITSCSENKCQETTVEATPSTATTVSEGVVTEYVTYCPVSSVETVASTKVITVVACDEHKCHETTAVATPTEVTTVVEGSTTHYVTYKPTGSGPTQGETYATNAITSEGTVYVPKTTAVTTHGSTFETVAYITVTKATPTKGGEQHQPGSPAGAATSAPGAPAPGASGAHASTANKVTVEAQATPGTLTPENTVAGGVNGEQVAVSAKTTISQTTVAKASGSGKAAISTFEGAAAASAGASVLALALIPLAYFI
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex mediates the import of some proteins while the predominant TIM9-TIM10 70 kDa complex mediates the import of much more proteins (By similarity).
Subcellular Localization:
Mitochondrion intermembrane space.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
Sequence:
MDPSMANNPELLQFLAQEKERAMVNEMVSKMTSVCWDKCITSAPGSKFSSSESSCLTHCAQRYMDMSMIIMKRFNSQ
The following text describes a protein:
Function:
Could catalyze the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product.
Sequence:
MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGDCQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGISAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL
The following text describes a protein:
Function:
Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell junction, adherens junction. Note=Colocalized with PARD3 at adherens junction and tight junction.
Sequence:
MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLETKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPHSPRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRSSSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMPNLAQKDSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYRSSAHYGYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLRGWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNWRTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQRLFWHEDSKPGTLV
The following text describes a protein:
Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Sequence:
MAAVSETVLVSAPQDHDAQAASDPQATAADSPLEDFRVRCTLKRAVMEVMEMCGRFVQELGAVLPEDVRELALRDAQWTFESAVQENVSFNGQAWEEAKEHGLMDSDIKVLEDEFDELIVDVATKRRQYPRRILESVIKTLKAQHASLKQYHPVVHPLDLKCDPDPASRVEDLKCRGEAIAKEMSEAMKALPVLIEQGEGFSQVLKMRPVIQLQRINQEVFSSLYRKADFKPDTCVTHVETTPAETGARKASNIVLKRKKAPDCAQRKRYPLRLQRINLDM