lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side; The RRM Nup35-type domain might be involved in the control of mitosis.
Sequence:
MSFGGSGSITNRSTLKPLSVDDLRSPSPQKEYRGFRTSVSNIPQEKKFVPSHLSHFGSSQQRRFAPEVSSPLAEPYESSSSFRLSLSSPPSSKFGGPSFGTPKPFLHTNRLGTGSLIEDAPPTQSIYDFSSSRQINALNVGQSSSPFSPVSEKVYDPSFTMSGAPQDSNTSVIVFGFPPELTNQVIAEFSRFGTIISENSLTASSAGFTPSKGPISGNWLQLTYAEPSSAAKAVLSNGMLINDSFMVGCIYSPAEAKEHVPKTLRNSNKDLEMTDASSSETSMSIPVHADAHFQSQSGLGKKVIVQHKNDIFKSSQKHQPRNWLFHYLFGFGSTEPIDEEEKSKTASDNTSLQTSLFGKIVQVVLHTLFGF
The following text describes a protein:
Function:
Palmitoyl acyltransferase that mediates palmitoylation of proteins and is required during embryonic heart development. Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MRSWRWSVSRIMRLFLRWFRLCPRRGHRKRSRVRDLWNYGMVVLKSLYYNVQTNSDTVLDCMFEPIYWLVDNMTRWFGVVFVCLVMALTSSVVVIVYLCVLPIIFSSYPVYWILWHLCYGHWNLLMVVFHYYKATTTQPGFPPQEKTDIPTVTICKKCIVPKPARTHHCSICNRCILKMDHHCPWLNNCVGHFNHRYFFSFCLFMTMGCVYCSISAKDMFLDAYNAIESGRYKGGASQGEAVPGAGLIYISFQHQSSYQTPPPAFTHQERMVHKSLVYLWVLTSSVAVALGALTLWHAILITRGETSVERHINRKERRRLKLRGKLFRNPYHHGRINNWRIFFGVEKGSDWLWRVLLPSTHPPLGDGLTWDCPAYKSSTTAI
The following text describes a protein:
Function:
Paxilline synthesis protein A: Part of the gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels. PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis. Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline. Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ. Finally paxilline can be mono- and di-prenylated by paxD. The exact role of paxA in paxilline biosynthesis is still unknown.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTSITTSVLVLHSLLAANFKYYQSFQNGFIDMLSAMADSNSVSGLPGQLCREYTGIRPLDTFLTSCTVFFWPTFQGEIPGLSLYGIAFASAMIPMWLIIVIDVHRRRQPFGALVELIAFAGPLIQCIGPGLVMPLLLARIHTPSRDSKSASQFDYRTFIPSMIIGYILPLLLASLPAPLILSYHNKQQFIAIWQGWPLYSSVLMWAFRRRSGHVHCSRHKGLKHACIFALACSSAGHLVLLSLTWLWSLSYWGYIQSAPWNEPPLASLEAGVLRFLQWDYTLSASATLSWAIAFRHEVVQQKSLRISLLSLLRCLIGIVFLGPCSMVALLYWQTCSLQEEAGQKAPAKDKQLDQEI
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSIASQLNTFVPTVNTSHIVSFIYDNNKAKFIDRYTLHRGALDSLNHLFKNHELLSEWKASLFGDESEQCNRDMLTDSQNKELSKKISNFLPYLSQHFLNPECGPIIEYMIRVYSINTVGANELILSFLSHYQNPLFIRLLSLCKPTIFTNFINLDRISRRDFVIHLTQFPTTLSTLINFYIDHPILIHNARYSTFICTLLISIAQQQIISEVVLTTLLSVVLQLIKSDSPKLTVVALSLSAQILSVHTLSESKFSSLLLVLHKYTATSHPSQFISVLCIGCKYQYSMKIFPQQIQTFLLNSVQMVVSTLIALSKKKCDLGDFVLLCLQTLNKDSISSKKYTELFGPIVNNIQLNERHLIIIVKHIFDVSKSVNKGKINYEYFNLLNNLDSKYPQEFSVAINEYFKQPDVANVELANQLKEILNSSMNMPLFEGYSYIGTIATVKKTGLITNATIAQIMTALKKSGEQFAEVKSVLVQLFNTPIKHSFYIELFNEDNYEKLIPVVSAEIVCEHLCKFCKLLPIEVNEVMMKYLSKLEVPRKWINELYGVFIPERDNVLQTLYILDLYLKYFSKLEDLFILKDIYESIGSQLESTLSKTDITFSELNSLYNTIIIIFGQYMEVNKLKELECNKKILLFDTIQFKSLGYKNNISYNDMLTNILIDSLKEQSNYNSCITSLFVELVQGDCFQYIEYLKLLPFNIALNSYNKSEKTKEETLKGLIGTTHYISFLNTIKSTLSEKEKSIIIQQHFIFVIKELMKESAKERTYGFDCLNEIGKLAKGYKENNIVIGGNKVLKSEYYLNYITAIQQSKIELTSSSNFITTFNNVYLNKINEKYRGLFVDHVIDVINKDHLLPSQEKMKVLMSFGMRSVDNIIGTMNMLNDSDELYDSQFEQKVLSEIIKSIVQTKYVGAFVGNKQLFDTFKKIIQMSNGENVVLISSLMNEEMWGMMDDIHQEEFLRILSVEHKDKRSQVINKLNRMLKITPFDLVNKIVMKIITMINTKESLQNKQLKKIPSVVIETTLNESNDKKMEEEVIENNNQGKEDESIMNELQFMVFVFESFFKVHKGSLNNINFEDNEFNKTFSESIKNISQLIQTTIKLPQCYHTDYLINIEMNSLIYTVGFVSKYLTFISTAKPIEQPRKKGTIIVRSKHDTFQNKIKKMTEDLASSIQVLTVIDVIYEVIETFGMTPAIYNGAITLLSQMIALFPTLFVEHSDRFVRALSKEEIVGIVVQKLIPHVISSISSAQGLPATSIVELLSMIVDNYNQLPYHRRREIFLQLFKESKLSEEHLSGVIVLLIENEADNVLPFIYDVFRELNNDKVIKLLACIIEDACQLLQENREGIFAGYQLKITKKKEVAHLCIDFVNGQITKREFIAKCMKTTEDVNIQQNYTILFKQVIEMLNKFDCTDENDSNTIVADKLHDMVDNISDLFSITTLIRAVVFLLKQSSIRVKRTALLILNQKLTALTPEEMSMYEASFLNAENGLIHVVIKILENVDKLNPSSVDNDAEQATIQTGVLLLEILLRFYGAQHISIFMDLLNYVLKCIQIKDTLKNIKIVASALLCLSIYAAELKTSLMPQLPQLIPMFFDLLPHGGDEDSVNSLINSVISCMMSFTKSYGNIVHPYINSFIPLILDSEYTSNPVVYPFIMEFMGVVGSSIEFRLVMSLVSSNFKNKKLQNDTSLAALFGLLSKSLNENQTSISQMRIKLYQFLFEALKTIPKISSPLNMKHCNDELIGVFNSLVLKLSDDTFKPFFLKCAEGFNEVVGISEIPSIYIYTKIILSFSKTLKSLFVPYYAFVLKNILSILNQLPLSLANALVPERSTLGKRSANNIKKGDNAIVLLDSIYLNIELLQTLFQNDNSNFVDSQKVEQLLPTVNLIDLMHNCYKEEDDYFDFITKRLSPCLCQFALCVPNQVCWKPLNHQLLIQTQHTDSIVRLAALHCMIHLWDTIAADIVYLLPETLPYLTDLMEDTNQEVVEAAKEFAQIVQKHLGADSLQKYLN
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEKGIFITGTDTGVGKTIVAATIARLLRDRGVNVGVMKPVTSGCIERDGTLISEDAELLTWAAGVPLDEACAPYRLRTPIAPSVAASREGVKIDFNHLKDAYETLRQRHDFVIVEGAGGLMVPLSGGMLVADLMSLLKLSLLVVARPNLGTINHTVLTCYAARQLGLDVRGVIVNSYPESPDMAEEYAPHLIDSLSGAPLLGVFPRIEGAEGRAMVEQLAARLATEPTTRILVREIGCA
The following text describes a protein:
Function:
Participates in DNA repair and in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MKMADRDSLKKNISSRFKINAFTLKKDALEFAVEKLEPFDKDKRAYWIKRLIEGLRKENFNGTVVDLDTLRNVTAAVSTSRNDNIPILNVFDVTSVPRWDIAPDGELIMHEERKENGLEVDNATMALRQRLMIVQTRISRTSELDGCTISPIDSLISSAPSEGTIIVVGVLVKIKNDQYHIEDLTGCIPIEITDQTTFHAGIFHIGSVMIFEGEWDGRVLITCAIALLPSHSADETRAYIGNSNLFGGTERIAFRSCPKLANRAARGADSSIVILSDVNVDNHDTRRALFLLLEGFTSCPPTAFILCGDFCSRPLQLDSNQLVEDGFIQLAKLIKQFPVYSNSQFIFVPGMKDGGLTNILPRPPLPQYLQKPFSSLSNCIFTTNPARVQLLNQEIVIYRNDTVERLCNNAIHVPDNLDNLPNDVVRSITSNAHLSPLPPSIQPIIWSLDSTLRLHPLPDLLIMADRFENYHVEQKGCIVSNPGPFGRLQYHFHVYFPDKRKIDPSSIDLSN
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPNCSCTTGGSCKCKECKCTSCKKSCCSCCPMGCAKCAQGCVCKGACSCCV
The following text describes a protein:
Function:
Required for efficient DNA transformation jointly with TfoX1.
Sequence:
MDKPVLKDSLRLLSSLGKITSRSMFGGFGIFIDDTMFALVVQDKLHLRASDETINLFKEQGFEPYVYKKRGFPVVTKYFAISPECWDEPDSILIQAVVALDVAKKDKEKQKSAGPSRIKDLPNLRLATERMLKKAGITTVEELKNTGSVNAYKAIQQTHSSSVSDELLWSLEGAIKGMHWSVISAETRNELRKQL
The following text describes a protein:
Function:
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MYRYKITLKDRQQLYKLIISQMLYDGYINLANGLINELKIHSVCAPSEQLLHLIKVGMENDDSAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHADEVTCLAFHPTEQILASGSKDYTLKLFDYSKPSAKRAFKHIQEAEMLRSISFHPSGDFIIVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVSYNPTANTYVTCSKDGSIKLWDGVSNRCVTTYEKAHDGAEVCSAIFSKNSKYILSSGKDSVARLWEISTGRMLVKYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD
The following text describes a protein:
Function:
Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MGIQGLLPLLKSIMVPIHIKELEGCSVAVDTYSWLHKGALSCSTQLCKGLPTSRHIEYCMHRVNLLRHYGVKPILVFDGGLLPMKIEQENKRARTRKENLVRAIEHESNGNSAAAYECYQKAVDISPSIAHELIQVLRQENVSYVVAPYEADAQMTFLSVCKQVDAVITEDSDLIPFGCHRIIFKMDKYGQGVEFQNSRLQQNKDISFVGFTNEMLLEMCIFSGCDYQQSLPGMGLKRAHALITKFKSYDKVIKHLRYSTVSVPPLYEESFKKAILTFRHQRVYDPTMKDIVHLSDLPDNIGNDLEFLGPYPSNRICHYSLIHSTFYLFLKLFGLYLNVKYIDTATDSYRYSKRGSGSVYSNAIPGSFFVYIFFVFISSFSSSSSFKIVDASSFRPWI
The following text describes a protein:
Function:
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
Sequence:
MSRRPKIEEAMKRVESRYELVHAAVRRTLQLLREGEDFFVQEGGEVHKKTFAAIEDIAEGKVKIIKKKEESGSKEE
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Localized predominantly at the plasma membrane.
Sequence:
MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL
The following text describes a protein:
Function:
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
Sequence:
MPQISKEALIEQIKDGIIVSCQALPHEPLYTEAGGVIPLLVKAAEQGGAVGIRANSVRDIKEIKEVTKLPIIGIIKRDYPPQEPFITATMKEVDELAELDIEVIALDCTKRERYDGLEIQEFIRQVKEKYPNQLLMADTSIFEEGLAAVEAGIDFVGTTLSGYTSYSPKVDGPDFELIKKLCDAGVDVIAEGKIHTPEQAKQILEYGVRGIVVGGAITRPKEITERFVASLK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MVEVSGTFKVIAKDIGGKIFEGVSRFKLEGEDLTVFVDINTDLFPLEEHDRIKLDLTKTLNRDGSPMDIHQGYSDNFGKNTKMDDFDYVMSGMVFKFVENKNDDNLSVIASFGGLLLMLYGKPEKLSAYNMKDQVYLLIRKTN
The following text describes a protein:
Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein.
Sequence:
MSEPVNKVKQTQQQVDDVTNTMHIAVGKMLDNQQKVSELTDKSENMKQGAQQFKKKTNEIKRLMWCRNIKLTLIIIAVVVLLLVVIIVPIVLKFT
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Sequence:
MGQRRREPCVAWPLLLLALAAGWGSVAGDMALSRRQDDSFSAASSVYGARCASRCLSLQITRISAFFKHFQNNGSLVWCQNHKQCSKCLEPCKESWDLKKNHCQSFCEPLFPKKNYECLTSCEFLKYIVSVKQGDCPAPEKASGFAAACVESCEADSECSGVKKCCSNGCGHTCQVPKNLYKGVPLKPRKELKFNELQSGQLEIKWSSKFNISIEPVLYVVQRRWNYGIHPSEDDATSWQTVAQTTDERLQLSDIRPSRWYQFRVAAINVHGTRGFTAPSKHFRSSKDPSAPPAPSNLRISNSTNNSDGSVNIRIIWDLPEEPDIPVHHYKVFWSWTVNSKSLVPSKKKRRKTTDGSQNYVILEGLQPNSIYMVELQAVTYWGQIRLKSAKVSLSFSSTQTAVHSKEQLSTVAKAPDVLPSFKGRRPARLLEIGVPFYQDDQLQVKVYWKKTEDVSSRSRYHVQWFAESCVHNDTKGPEKSSSTTYDNYIVLQNLSFSCKYKVTVQPARSKGQLKAETILFTTPTCSDLKGKKHKHINCPIEEALIIPKVLAKPENLSASFIVQDINITGHFSWKISKADLHQPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPVDHYVLTVPNLRPSTLYRLEVQVLTTGGEGPAMIKSFRTPDLLTSPHRPHLKQHHPHHYKPPPEKY
The following text describes a protein:
Function:
May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MPATKTKFGLLLFLTQWVVYSEAWFWSWSGTTTRLPQTLEYEGSGSPTGSGELPSEITTKAEGDMVHEGHGTPNIKQTWVLTTEDPQMSTVTPATLRETDDASESVTARIPPQSTSGNGTSTLTALGSDPSRILKNASKIESEVELAVELDSKHGGFSSSGLLPVAENMASLVYEDGAVKQADRRGLDNASGAAFHVKKVGLRLSERVSTIASKQEFSKASVRAVGIGKGIHAQTENASSISCLVLDAALPFCSSKFGETFAVPNYFNHSSLEEVQALLKEWAWLLESRCHHSLEWFFCLLLVPKCDPATPMLTLPCRSFCEVLLDSCWALLEGQHLPVECHTLPDASHGYQCLSVCNQNEDNGVSLLQLIGDPPPSEISQVYGPDNAIGYVFGPDAKMGQLAVAHFPTPFYRDFSLNFHLKPTSNEGGVVFSITDSSQQVIVVGVKLSTVERQTQDVIFYYSETGSEQSYEAARFQVTSMTDTWTRFSISVRDDKVAFYFNCDLSPVVKRFERSPDDMELERGSGVFVGQTGGPDPERFLVCICFHPTQPNVVFYTQCHRTTDFSKWNLGDGELLAGFGYQGKKGDPGQPGPPGPPGPPGPSTEYVPSSDGTVVSKVQGPRGPPGPPGPQGQPGEDGEPVCRWFHCQHTFFLKKHHIFNKVFRSFSIISLFQVLILIHAVTFFSHLLLCVQGEKGEPGLIIGPDGNPLYLGGLTGQKGDIGPQGPGPPGLKGEIGMPGRPVSIHQNGVPGPPGPPGPPGPPGPPFAIDRFNVRTASDFDIYTLKNQWKGERGDPGVKGEKGEPGAGHDPQYGALQGPLGPPGLPGPKGDSIMGPPGPQGPPGSPGIGYDGRPGPPGPPGPPGPPWSQTLPESYKPNYPVSVPGPPGPPGPPGHPGHSSGVMVLRSYDTLIATARSQEEGSLIYILDKADLYLRVRDGLRQVMLGEYNPFFRDFDNEVAEAQPPPVVLYPHSPDHSQNNGASQYSQGGSVIRPIETPPPVERRYPPQYEPRFPDQQRPSQTDGRLINQPSDGKYAVTPQRRPNPPVPGPVETSTLGVSGLRLIALNTPQSGNMKGIRGPDYLCFEQARAAGLRGTFRAFLSSKVQDLHTIVRHSDREKPPIVNLKNQVLFDSWQSIFGESVSKMRKNVPIYSFDGRDILRDSAWPEKMVWHGSSKKGHRQTDQYCEAWRAGDQAVTGLASSLQSSHLLQQTPTSCSRACIVLCIENAMVSPSK
The following text describes a protein:
Function:
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).
Sequence:
MDPETCPCPTGGSCTCSDKCKCKGCKCTNCKKSCCSCCPAGCEKCAKDCVCKGEEGAKAEKCSCCQ
The following text describes a protein:
Function:
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Subcellular Localization:
Cytoplasm.
Sequence:
MTKIAMANFKSAMPIFKSHAYLKELEKTLKPQHFDRVFVFPDFFGLLPNSFLHFTLGVQNAYPRDCGAFTGEITSKHLEELKIHTLLIGHSERRTLLKESPSFLKEKFDFFKSKNFKIVYCIGEELTTREKGFKAVKEFLSEQLENIDLNYPNLVVAYEPIWAIGTKKSASLEDIYLTHGFLKQILNQKTPLLYGGSVNTQNAKEILGIDSVDGLLIGSASWELENFKTIISFL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLTTPSELTMQSAIDVFNEQTRDLPRDQIYDAKDCDSVSSHITREVPLGSIRTNGPASSASQDEISAKDLCSAICGCLWVYKARRLARAATIEKYTDKASVVTRPRPPARLIRHMVDEHRKYAEEPITATSPLFTVGNGVGTCDLPPQFAYFFQFSHLSATRNLLCLDLDETLVCSKQRTPQTRETEDFYVVVEQRGKRYEFSVIKRPGLDVFLVSLAELYDLAIFTYAIKEYGDKIVNIIDPNRLIKYRMYRQHCVKYLVDKRHVIVKDLSRVGKPHSSILLIDNSASTGIWQRNNFLLVPSFYGDERDKVLYELKELLEGISKCKDFYTEIQSLRSVM
The following text describes a protein:
Function:
Has a role in meiosis.
Sequence:
MRKQAGGPCEKLNFPLVELEPYARVNRETTKLNKAHVRRDYSGRSICQPDTNNPTRWKYERPLETIRAWQDVAEGKVPASNEKAARVSNLKTVPSLKRENKEVNANSKPPVKQQEVIESTVISKSQSPSVKQLKLTESTLLAPSSSLKPSVSLKKDISSNLLCAAASNGYFRRPAAMRAQTLVPITQPDSKKNELKQKFKHLVHHVLT
The following text describes a protein:
Function:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol.
Sequence:
MPGKMSVILLGTGASFRFFRKKNVEAKPSEGADRILGLRDEILAECPEAQVEGKVGRSGSFEVTINGKEVFSKLKQGGFPVCDEVVNSVIEACKGLDPPHVEEVDKSGCSIQ
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSPTNNGRNKKLGPRRKVPGRVSKSKSRAKVQAGDAKRVLDANALKWEKVDVPDTLGDFGGFYGLEEIDGVDVEVVDGKVQFVARDESRLKSPADAVDGTDMVEVDEDAGMEDVTEFRNLDDVAEGELSALSDEGSASEDDGSDSSGSSDMDEDDDQELQSEIFNKDIGLDEAEAPELPSWTNTMKLSATVLQGLSRLGFSNPTEIQLQSIPKALDGHDIMGKASTGSGKTLAYGIPILEGIIRDDTDSRPIGLIFTPTRELAHQVTDHLREVGALLVKRNPYSIMCLTGGLSIQKQERLLKYKGSARVVVATPGRFLELLEKDQTLIDRFAKVDTLVLDEADRLLQDGHFEEFERILKHLSRARKFTNGKKHGWKTMIYSATFSLDYFNKLSNTSWKKMKKAPSENEMEEVLKHLMTKIPFRGKPLIIDTNPEQKVASQIKESLIECLPTERDLYVYYFVTLYPGTTLVFCNAIDSVKKLNAYLHNLKISAFQIHSSMLQKNRLKSLEKFQEQAKKNQALNKPTVLIASDVAARGLDIPGIQHVIHYHLPRSADVYIHRSGRTARAENEGVAVTICSPQEAMGPLRKLRRVLAGKAGSKGKRWQNEIALLPVEPDIVSQLRERSRLASALADSEIATSSLSKDDNWLKKAADDLGIDVDSDDETKDTFLAKNKTKKLNKQLDKSTSKSYKMELNALLNTPIRKDARKSYLTGGLSNLADDLTKKKGHSSIIGHDKVDALTLLKSKSKRAKR
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
Sequence:
MPALIFYDTETTGTQIDKDRIVELAAYNGTTSESFQTLVNPEIPIPAEATKIHGITTAEVADAPRFPEAYQKFIEFCGTDNILVAHNNNAFDYPLLVRECRRHGLSEPQLRTIDSLKWAKKYRTDLPQHSLQYLRQVYGFEENQAHRALDDVITLYRVFSALVGDLSPDQIYDLLNETCHPRIFKMPFGKYKGKPLSEVPSSYIAWLQKGDYLLQPENKEIKAAIEAYQQLK
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MKRLAALDIGSQKTVFVIGERDSYGDIHIIGFGEVPSRGIVKGVINDLSEAKGSILRAMKEAEAMAGLKVREVVYNVSGGTTKNGTVKSQNVKDTISISTKSSEIEESHIQRLHERCLMKAKEEGYEIVYTAPRKYILDDHTEVKNPLGLVGSKLSVEMHVVKVSTTILRNLEKAIREVGLNPVGRTVNAIASADSVLTHDEKEDGVLLLDMGAGLTDYSLYTEGRPYITGVVPFGGINITKDLSYMLKIDTETAESVKVNHGVAFESLVDDEDVVKIKPRGEDREIPIQKKQVAEIIQSRVEEIVEKVFKEIKARGVPLNQINSGIVVTGGTANLKGIRELIEHMTGLPVRIGLPQGIVGLREKIENPKYATVCGLLRQAFVSGTIDITESTNSNTGNFFKNLSERFKKWFEELL
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMTYNEILGIVHLQVAGIGLLGNCIILFLNIQNFITIHRIKPKNQIISHLAFSNIILLLFGGITNGTRIWRLKCLLEELGIRIITYWQTMGRGLSLGSTCLLSAFQAITISPNKSRWEQLKIRSPKCITQCILLCWVFNLLLDMIVFFCPITPQNSTDSKYGCNTGYRILDINNENHVKIRMISCVHDCFFLCLMTCSSVYMVVILYRHKRHVNHIHKNNRSIKILPETRATQMILLLVSAFVLFNIFSPVFMLYMFYFKNQNTWIIPTSVFLSLAYPTDSPFLLISINNRIPKTYVL
The following text describes a protein:
Function:
May play a role in fertility regulation.
Subcellular Localization:
Secreted.
Sequence:
MSHHSPPPPKHKGEHKGHGLPRGSERGSSSRGKDRSASVSNSVPMPAGGKASRTNCPPPAPQKTANRLINEKSPYLLQHAHNPVDWYPWGQEAFDKAKKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGHLLNENFVSVMVDREERPDVDKVYMTFVQATSSGGGWPMNVWLTPSLQPFVGGTYFPPEDGLTRVGFRTVLMRICDQWKQNKNTLLENSQRVTTALLARSEISVGDRQLPPSAATMNSRCFQQLDEGYDEEYGGFAEAPKFPTPVILNFLFSYWLSHRVTQDGSRAQQMALHTLKMMANGGIRDHVGQGFHRYSTDRQWHIPHFEKMLYDQAQLSVVYCQAFQISGDEFFSDVAKGILQYVTRNLSHRSGGFYSAEDADSPPERGVKPQEGALYLWTVKEVQQLLPEPVGGASEPLTSGQLLMKHYGLSEAGNINPTQDVNGEMHGQNVLTVRDSLELTGARYGLEVEAVRALLNTGLEKLFQARKHRPKAHLDNKMLAAWNGLMVSGFAVAGSVLGMEKLVTQATNGAKFLKRHMFDVSSGRLKRTCYAGAGGTVEQSNPPCWGFLEDYAFVVRGLLDLYEASQESSWLEWALRLQDIQDKLFWDSHGGGYFCSEAELGTDLPLRLKDDQDGAEPSANSVSAHNLLRLHGLTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRALSAQQQTLKQIVICGDPQAKDTKALLQCVHSIYIPNKVLILADGDPSSFLSRQLPFLSNLRRVEDRATVYIFENQACSMPITDPCELRKLLHQ
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). Required for correct subcellular localization of pgl-1.
Subcellular Localization:
Cytoplasm.
Sequence:
MAMKIPKSGYNRFMKEGAQHFKGTDEAVQRNIEACTELASQIRSAYGPNGMNKMVINHIEKLFVTNDAATILKELEIQHPAARIIIMATEMQEKQIGDNTNTVVILAAALLEHAANLIHMGMTPQEVAAGYEQAAEKALEILPTLVVKEATDMKNIEEVRQYIRSAITSKQYDNEDIIADLVAKACVTTCPANSFNFNVDNIRICKIIGSGVHTSTVMNGMVFKRGAEGEIREARDARIAVYTCPFDLTQTETKGTVLIENADELRNFSKGEEAEVEEQVKAIADNGVKVVVAAGKFGDMYLHFLNKYKIMAVRLTSKFDLRRLCRTVGAQPQARICAPAVNLLGHCDSVAVQEIGDENVVVFDKKSETGKVATIIIRGSSQSRIDDVERAVDDAVNTYKALTKDGKLLAGAGAVEIELAKEIESFGAKAPGLEQYAIKKFAHALETLPKAIAENAGMPTTETLTKLYAEHVAGKKNAGIDIWKRETMDAVVNNIFDLYAGKRLAIKLATDAASTILKVDQIIMSKQATGGPKPRGPKAQDEDDDGMA
The following text describes a protein:
Function:
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. Required for synaptic function and plasticity at larval neuromuscular junctions (NMJs) by promoting neurotransmitter release. The DCX(DCAF12) complex catalyzes ubiquitination and degradation of yorkie (yki), thereby regulating the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a regulator of tissue growth during development: required for the apoptotic elimination of supernumerary cells during metamorphosis.
Subcellular Localization:
Cytoplasm. Nucleus. Presynapse. Note=Mainly localizes to presynapses in larval neuromuscular junctions.
Sequence:
MFNGMVRTIRDSVVGTYPSCHVSSRLEERRAKQRAMRQERRRKPDKPDDFVTYEDSGSDEETPQQQEEVLNTSYNLCDYLRSRESGLRDRRSVNVEYTSRYVLTHDMLRETQISLGYINKVFCSKWLSSRQVVFGTKCNKLLVYDVNMRRVDAIPTLSNSRANHPEVQGGLHAIELSPSRSFLATGARNSSDIAVYRLPTLDPVCVGEGGHRDLIMGMCWLDDQFLVSGSKDSRMALWRINEDHMEFPDGGEEACPTFATIHPLSVKEVRTAQRIRSLCFNKEFKEIAALSLNGYIHIFNAETFKQTLSRKLPNCQDNVSIAYHSDGLYAVGCRSYTILLDARTLQTIKKITSRYSGCGIRATSFEGNLLTVGTGLGMLLFYDIRAGKYLESSVNASRTVALKCSKGIVYPEDEMDGFQQVKYVPAIYTHCYDSTRMRLFAAGGPLPATLVGNYAGVWQ
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MRQAGAYSGILSRKTGPHSLPLARIKKIMKKSSDDVKMISGEAPIVFSKACELFIEELTKRAWIIMTNNNMHEKRRSTLQKDDVASAIIATDVFDFLVNLVSNTTHDHNNCEELNDEESRQDSP