lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MESLSNLGNAMSSVLSETTSTTATAILADPTEALSSVVALASDAVSKATSDVVPEHTPTSWFTIILWLLHRISSVLYFVIKLTTITTPTFLFNIFSTSLTVTMNATTLVLIMLFMMAGVTWVVRYRYLNMYSRLPPEPQRKEPAVDLFPETQEEGVKSGLASYFDEFLSAIKIFGYLERPVFHELTRSMQTRKLIAGETLNLEEEQGFCLVVDGMVEIFVKSARDGRRSSSGPSFESDDEEGFAPGRQRYQLLTEVRNGAPMSSLFSIMSLFTEDIQMHDTDDDDSPDPTPSAPGTAMPGYPMNANFQQSNDTLPSIPGTPLSDNHVMQRGMASAESLTMSPLAHDSSRIPSLSLVNTRPAVPRRPVPKRLNTTSAHPDIIARATVDTTIAIIPASAFRRLIKIYPKATAHIVHVILSRFQRVTLATAYNYLGLSGEVLQMERNILKHTVRQLPNHLRGDALDRLKEKFKRERERIGEKEVEKGIALHNAHAARRRRSAASLRKEVALQAYSKRRQSIVTATPAFGTRRERPSPDMPSPGDLLTNTQQLKSGPASQLDLARDATSPRPQRNLSPFSTPRNAHVSLDTREALDEDDMFRESVLECMFRAIGLTGNGSVNPDSTQASPRFVPTDQRRSRGGPGHTAFGFMDAFDPFDNDTESVTSCGFSSSSPVPNPQLLAHDMKDEVEIVFFPKGSVLVEQGERNPGLYYVIDGFLDICVPGDDSSHDLLQSSAKVDHGHDSATGADAFGANSSRFPEPNMNNNFGAEQKKGKQGRRSVALIKPGGLAGYVGTISSYRSFIDVVARTDVCVGFLPLASIDRIVDRYPIVMLTMAKRLTELLPRLLLHIDFALEWVQVNSGQVLFREGDESEAIYLVLNGRLRLVEDQKDGGMNVKAEFGQGESIGELEVLTESARTGTLHAIRETELVKFPRTLFNSLAQEHPNITIKISKIIAARMRAFIDDPSRMGLKDNVVRSYKSSSTLNLRTVAILPVTAGVPVVEFGNRLMNALSQVGPPNGATCLNQAAILNHLGKLAFNRMGKLKLSQYLADLEEKYGLVVYVADTNVNTPWTQTCITQADCLLFVGLADSSPEIGEYERFMLGMKSTARKILVLVHQERYSNPGLTRQWLKNRMWINGGHFHVQMAYTSNTVPIHPPTKRFGPSLKQRVQILQAEIQKYTSRKVRHVPFYSPDAPFKGDFHRLARRLCGKSVGLVLGGGGARGIAHVGIIRAMEEAGIPIDMVGGTSIGAFIGGLYARHADVVPIFGLAKKFAGRMASMWRFAFDLTYPSASYTTGHEFNRGIFKTFGKTQIEDFWLEYYCNTTNISKSRVEFHTSGYAWRYIRASMSLAGLLPPLCDEGSMLLDGGYIDNLTVSRMKSLGSDVIFAVDVGSLDDNTPQAFGDSLSGVWAFFNRWNPFSSVPNPPTLAEIQARLAYVSSVGELERAKTMPGCIYMRPPIDDYGTLDFGKFDEIYGVGYKYGQEFLQKLREQGVLPLVEETEAKKALRRTMAPRRASI
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MSTTSAKNSNKNNKRRFSDEQIQSLETTFGTESRPELRLKHHLADKLGLQPRQIAIWFQNKRARSKSKMIEQEYSELKSSYDNLALQFEALRKENQTLLIQEFGIFDLISTPNLWKNELLYCGLQRIVHWITPLIQLHNRANLYIRQVQRLRKMTEKSDGEENDHENQITPPKTSENPTFLLDMNNHDMCVTSCSDLNRKIDYLEEDAADILNMAEIAEDSLLASPENGCSFDSCAFLDNTAAGGTTSQWWDF
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MKIFQPNWVHHDEKSIFSIDIHPSGERFATGGQGCDSGRVVIWNMAPVLSEQAEANKSVPRVLCQMDNHLACVNCVRWSGNGLMLASGGDDKLVMIWKKTLSGSGGGIGAFGGGGGKSVEHWRCISTLRGHAGDVLDLAWSPQDRWIASCSVDNTIIVWDAQQFPKIVHVLKGHTGLVKGVTWDPVGKFVASQSDDRSLKVWKTTDWSCFKTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIERDGWKCDKDFVGHRKAVTCVRFHNSILKRSAPKTNKLQQYCCLAVGARDRSLSIWLTALQRPLVVIHDLFQDSILDLSWSCDGYTLLTCSGDGHIACLQFTAQELGTPLSEEDKNILYQRMYGKNANIDLTAQAEKEMIVENSDFLNVSKSNPLPPTLIPQQQQQQQPQLGGMRQDGADKVVQPASQPAAAIKSSSSLAAPTPILKQIETKTADGKRRITPMFIPLNDDNGPALHATNNIMPSSIEFGSKSSETSTVEIKQRAHEEPTIIPPPAERATGEPTSKLDNRLKKMATAPPQKAEPMTVPTDPQQQQQQQLSAPSSTIQPAANQKLMDRTRQPATYPTGKATVIQGHSFKAFGEVRVQIQNNTVKTSYGTLSRVVGVVVTAQRVERKLWETVVGSPIVCFAVGAKYAIVCSQDHTIRMVDIKTGTPVFPVLSLTSPAVLSAFSSNSQLAGVVTESGILRIWSVPEKAVLLSTSCAEIMSGSFVTILHVSDKGMPFIVLSNGSSYSYCRKLDSWMLINSSDPVIRHGLIGNKTNAPVRNIKTYPLSTIQSYGSFSGPKTNSFAELHSAAWQTSAAIAFIENQIKICEMIASPAELKYWYSMLGFQLALNGSEEKIRQVLDDLLGASHNSLDPCRTLAGDDADDRSVLGISKQLLMEDVLNHLKTQTKWQRIYTEYLDQLKFLKERDGGGGGRDKPLME
The following text describes a protein:
Function:
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Membrane raft. Endosome. Cytoplasmic vesicle. Cell projection, dendrite. Presynaptic cell membrane. Synapse, synaptosome. Mitochondrion. Membrane. Cell membrane. Perikaryon. Cell projection, neuron projection.
Sequence:
MDETSPLVSPLRDSNDFNYGPAEPTSPRGGFGSTPGSVVRLPAGSPGRSRERQPLLDRDRGASPRDPHRNEFPEDPEFREIIRKAERAIEEGIYPERIYQGSSGSYFVKDSAGKIIGVFKPKNEEPYGQLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFHRIGLPPKVGSFQIFVEGYKDADFWLRRFEAEPLPENTNRQLQLQFERLVVLDYIIRNTDRGNDNWLIKYDYPMDTSSNRDSDWVLVKDPIIKLAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVVFSQEIRDLVLPKLADPNFIKDLEEDLYELFKKDPGFDRGQFKKQVSVMRGQILNLSQAMRDGKTPLQLVQMPPVIVETARVPQRANSESYTQSFQSRRPFFTWW
The following text describes a protein:
Function:
Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MYRERGVAGSRSEVGPVSDRKQRINDALDKQLERSSPSTSRTATLINGKDKSIFVAKPPPDQTDSLASNNFSDEESETDSEGSDVSGSDGDDTSWISWFCNLRGNEFFCEVDDDYIQDDFNLCGLSSQVPYYDYALDLILDVESSHGDMFTEEQNELVESAAEMLYGLIHFRYILTSKGMTAMLEKYKNYDFGRCPRVYCCGQPCLPVGQSDIPRSSTVKIYCPRCEDIYYPRSKYQDIDGAYFGTTFPHLFLMTYGHLKPQKALLSYVPRVFGFKIHKP
The following text describes a protein:
Function:
Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment; Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MVCRSNLTWNARRMTLLAFILLLSFLPAESAKSRYPPKTSLNPVFGPQQVYGLIDGSVSIKCFYPPTTVNRHDRKYWCRESSRSCLTVVSTSGYRARGYQGRVTIVDFPEQGIMLVNISQLTLADQGTYQCGIGLNGKGLSNRVSLDISEGPNIPEEAELFYVELQGSVSMACDFGEDYASTRKFLCKMEKSGCRNIIDTYGKIDSDFQGRILLSNENTEGAFSVMITQVDWEDAGLYLCGVGSYGEYGETKELDLHVYEGTKAAQGKHTIFGVKGSSATIDCHYDPTKNYSLKYLCKWRTTGCARIIDNTGFLPGPYEGRVAMFDNPKNGTFSIVLNQLSSRDEGFYWCMTDDHRERRTSKELKIVEGECGLTGKEEVQAEVGSRVDLTCSYPCKYYSYEKYWCKWSRDGCTPLTSSDQSHPGLDVSCDTANKTLILSLDPVTVEDQGWYWCGVKHNGHYGETMAVSLQVDGGKAANISPELLDLEASNAAAAPDEAVPQGRANSDAGVQRAAASESSEQSSGSSTLALILGPIGAALLVLAAAFAVFKYRQIRRSDLVSVGSYRTNISMSDFENAREYGANDNVCMKQSQETQLGGDEFVTTTANTESTAETKKAKRGSKEDADLAYSASLLTPSTTTQSPAGDSTAPAEAPPLWGGSV
The following text describes a protein:
Function:
Possesses multiple, substituting fibronectin (Fn) binding regions, each capable of conferring adherence to both soluble and immobilized forms of Fn. This confers to S.aureus the ability to invade endothelial cells both in vivo and in vitro, without requiring additional factors, although in a slow and inefficient way through actin rearrangements in host cells. This invasion process is mediated by integrin alpha-5/beta-1. Promotes bacterial attachment to both soluble and immobilized forms of fibrinogen (Fg) by means of a unique binding site localized within the 17 C-terminal residues of the gamma-chain of human Fg. Both plasma proteins (Fn and Fg) function as a bridge between bacterium and host cell. Promotes attachment to immobilized elastin peptides in a dose-dependent and saturable manner. Promotes attachment to both full-length and segments of immobilized human tropoelastin at multiple sites in a dose and pH-dependent manner. Promotes adherence to and aggregation of activated platelets independently of other S.aureus surface molecules. Is a critical mediator implicated in the induction of experimental endocarditis in rats with catheter-induced aortic vegetations, promoting both colonization and persistence of the bacterium into the host.
Miscellaneous:
MISCELLANEOUS: Fg-binding activity is not regulated by the divalent cations Ca(2+), Mn(2+) or Mg(2+); MISCELLANEOUS: Deletion of the Fg-binding domain of FnbA abrogates the ability to promote cardiac valve infection and persistence in vivo; MISCELLANEOUS: The mutagenesis studies described in PubMed:17302800 were done with region A alone and not with the entire protein; MISCELLANEOUS: Mutants lacking C-terminal residues from the ligand binding A region bind to Fg with a reduced affinity or are unable to bind to both Fg and elastin, depending on the extension of the deletion present in this region. Individual constructs of regions spanning amino acids from 194-336 or 337-511 were unable to bind fibrinogen or elastin.
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A.
Sequence:
MKNNLRYGIRKHKLGAASVFLGTMIVVGMGQDKEAAASEQKTTTVEENGNSATDNKTSETQTTATNVNHIEETQSYNATVTEQPSNATQVTTEEAPKAVQAPQTAQPANIETVKEEVVKEEAKPQVKETTQSQDNSGDQRQVDLTPKKATQNQVAETQVEVAQPRTASESKPRVTRSADVAEAKEASNAKVETGTDVTSKVTVEIGSIEGHNNTNKVEPHAGQRAVLKYKLKFENGLHQGDYFDFTLSNNVNTHGVSTARKVPEIKNGSVVMATGEVLEGGKIRYTFTNDIEDKVDVTAELEINLFIDPKTVQTNGNQTITSTLNEEQTSKELDVKYKDGIGNYYANLNGSIETFNKANNRFSHVAFIKPNNGKTTSVTVTGTLMKGSNQNGNQPKVRIFEYLGNNEDIAKSVYANTTDTSKFKEVTSNMSGNLNLQNNGSYSLNIENLDKTYVVHYDGEYLNGTDEVDFRTQMVGHPEQLYKYYYDRGYTLTWDNGLVLYSNKANGNEKNGPIIQNNKFEYKEDTIKETLTGQYDKNLVTTVEEEYDSSTLDIDYHTAIDGGGGYVDGYIETIEETDSSAIDIDYHTAVDSEAGHVGGYTESSEESNPIDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEESTKGIVTGAVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPVEEITKNNHHISHSGLGTENGHGNYDVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQIHGQNKGNQSFEEDTEKDKPKYEHGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKDKPSYQFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPAEPGKPVPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVAPTKKPQSKKSELPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MRCFKATIAYDGAYFLGYAKQPNKLGVQDKIEDALNALGIKSVVIAAGRTDKGVHANNQVLSFHAPKHWNAAKLFYYLAPKLAPHIVLKKLEEKNFHARFDAQKRAYRYLLTKNLKTPFLAPYIACGDYGSLDALNTALKQFTGKHDFSMFKKEGGATTNPKRTIFNAFAYKTFIIGHECVVFKIIGDAFLRSSVRLIIQACVQYSLEKITLAEIQAQIHNLKATIRTPIMANGLYLHRVYY
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Membrane, coated pit.
Sequence:
MSTNMRGLNTFITDIRHCSNKEQEEKRVEKELQKIRGKFTSQKGLAGYQKKKYVWKLLYIYILGYEVDFGQQECAFLINSSKFSEKYTGYVATSILVSEKTHDLFTQVASSIRNDLQSVNEINQSLALTMVGTQAPQELVNALHQDVQKLALTESRSTFHVRKKACACLLRMYRKYQDKFQPSQWAQGISQMFESRHPSLGFMTAATSLLVGTCQLNNPSIFEDCTPKLIKLLHKIAIQKDSPGDYNYYATPAPWLQVKILKALSFFSPPPPSTDSHRQLTECLTKIIKKTEVTKSINKNNVDHGILFEAANLVITYNGAVGMELKNDILKLLGIFISVKEPNLRYLGLETMCKFVKLAGDSLEDHLNTIFKSLRDNDISIRKRALDLLYLISSPNTSQRIVEELLSYAENGADLQIKDDLVLKIAILSEKFADNLYWYIDVVVRMINSSGDFVTEDIWFRIIQIIVGFQKEGNQELQKYAATKLFSQLSMPHVHETLICIGAFIISEYSQMLVEQNKEPQKLFDILNKHYTFSTERSRQMLLNAFVKLACKYPELRDQAIMICQIAGEHFDPDIQQRGIEYFSLLMEDDKLLNQIVVKMPPYSELVQQNNPLTKRIYVMVLNPKEQKDPTLLNQARIQASQEIAMAEQRLQSKPEQLQKHLSWLKACPYLNQFQGQIALEGVNIMVPPSPEDNNLKSPSISNVNEIKVLLTSQIGKVVDKPGDLVVQYKSEISGHLGKVSFQFEGASPIQNLSILVSQTNGMLFNILPVKQGDFPQVMMQVLSCDGNMTLPIASVFYEQNGQQKKHEFNLPIYTNKFVQPVDMPYDKFTKFFDDFTNNLSNQNYFKLDSFIRNTAPSNIPMSEVLKKAGGLLSVGLNLKAQPFPSLENLQMIWACGQLMIKPPEQSNILNLPIMVIISSLDQTNEFLRVGIRCGGSGEIAKNYMKLIMLYLG
The following text describes a protein:
Function:
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
Sequence:
MEPETPSKAHVVSSLMSVKRNSGKTFGQIASETGLTNVYVAQLLRRQAQLKADTAPKLRASLPGLTDTHIQQMMEPPLRSYDPSILQDPTVYRLNEAVMHFGESIKEIINEEFGDGIMSAIDFFCSVDKVKGVDGKDRVVLTFDGKYLPHTEHKVEHMVSRLNLQKD
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEVSPVEENVIEEIVSFEEEVETFLINLHDFVYHRNAEAIKKLFDTDFYTISEIYFKNIRWPSIKLVDIFYKQKNRFHNLIHSLYEELYYRHVFIIKDITLEDRKNSWDNYKCLLNFITTICTDLSGDSNDNVLVMPNVWIYDFLSEYIYQYQSMCHYRLQLLKDLEKNEEGILFVTRNTEVFESSIVFEVLHNLLLKGEFSTLPLEEKSTFVNNIYNINNEEINSKYQFAYFACCILLNLYVLIGDYYTALKIISNIELNHKALYWKVTLCHLSIFYNIAFSYMMLKRYNDSIKVLSQILIYLSKQKIHVSNQQKYQQNLIHKLIDKMYLIIIICHSLTNTRLDETILQNIKENYSGKFYALQSANEQTYAELFIRVAPKFIDPLSNISFQILSNFQNIQNQTYSSDPTNRQLAIFLKDVSYQKKAFYFISYAKLYHNIQLKKLANLMNYNELINNDDEHEQEQNVSSDIMCVKNCSKQLIWKEGPLYTGDIINSIFGNSFDFFIDLDIVNIKTRAHQKIFIDYFVHQINMSKNLMNNLLGAASTHMYKTKYDNFRKKLKNKTRNKHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYYYYHKNKQNKQDKQDKQNKLNRQNKQNKQNHLNRHNNQNKPNHQNNMHAQVAAS
The following text describes a protein:
Function:
Negatively regulates the abscisic acid (ABA) signaling pathway. Required for full susceptibility to filamentous (hemi)biotrophic oomycetes (e.g. H.arabidopsidis and P.parasitica) and fungal (e.g. E.cruciferarum) pathogens, probably by triggering the repression of ABA-sensitive COLD REGULATED and RESISTANCE TO DESICCATION genes during infection, but independently of immune responses. Involved in BAK1-dependent and BAK1-independent microbe-associated molecular patterns (MAMPs)-triggered immunity (PTI) leading to defense responses, including callose deposition and MAPK cascade activation, toward pathogenic bacteria (e.g. P.syringae). Required for chitin-mediated PTI.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAFSSCFLLVLLQIFSALLLCLAQDQSGFISLDCGSPRETSFREKTTNITYISDANFINTGVGGSIKQGYRTQFQQQTWNLRSFPQGIRNCYTLNLTIGDEYLIRANFLHGGYDDKPSTQFELYLGPNLWSTVTTTNETEASIFEMIHILTTDRLQICLVKTGNATPFISALELRKLMNTTYLTRQGSLQTFIRADVGATVNQGYRYGIDVFDRVWTPYNFGNWSQISTNQSVNINNDYQPPEIAMVTASVPTDPDAAMNISLVGVERTVQFYVFMHFAEIQELKSNDTREFNIMYNNKHIYGPFRPLNFTTSSVFTPTEVVADANGQYIFSLQRTGNSTLPPLLNAMEIYSVNLLPQQETDRKEVDAMMNIKSAYGVNKIDWEGDPCVPLDYKWSGVNCTYVDNETPKIISLDLSTSGLTGEILEFISDLTSLEVLDLSNNSLTGSVPEFLANMETLKLINLSGNELNGSIPATLLDKERRGSITLSIEGNTGLCSSTSCATTKKKKKNTVIAPVAASLVSVFLIGAGIVTFLILKRKKRTKLGLNPNSGTGTTPLHSRSHHGFEPPVIAKNRKLTYIDVVKITNNFERVLGRGGFGVVYYGVLNNEPVAVKMLTESTALGYKQFKAEVELLLRVHHKDLTCLVGYCEEGDKMSLIYEFMANGDLKEHLSGKRGPSILTWEGRLRIAAESAQGLEYLHNGCKPQIVHRDIKTTNILLNEKFQAKLADFGLSRSFPLGTETHVSTIVAGTPGYLDPEYYRTNWLTEKSDVFSFGVVLLELVTNQPVIDMKREKSHIAEWVGLMLSRGDINSIVDPKLQGDFDPNTIWKVVETAMTCLNPSSSRRPTMTQVVMDLKECLNMEMARNMGSRMTDSTNDSSIELSMNFTTELNPGAR
The following text describes a protein:
Function:
GPI-anchored protein involved in proper cell wall integrity. Does not seem to be directly involved in the synthesis of the cell wall. Required for normal virulence in a mouse model of disseminated candidiasis.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHFSKIIAGSALSSVALAEFQNGTVTTHVTATGYTTYCPYPTTITLTICEEENICTKRPIVVSEPTTVTVTEPCIISTSYETTEVVVTTTLPSSLSPSSVAPANVTSFEGAGSKNVASALVGVVAIAAAMM
The following text describes a protein:
Function:
Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
Sequence:
MFMVGFVVVSHSKELAEAAIHLANEMKRYDFPLINGSGTDGNFLGSNPLIIKEAILKAKTDKGALIFVDIGSSVLNTQVAIDFLADEDVDIENIKIADVPLVEGLIAGVAVNDEKADIESVLEELNELKTFSKLTY
The following text describes a protein:
Function:
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
Sequence:
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MMVQFGLLCKTTTLLFVLHVLVSVSHGNLTTTETSIAGSIPTNNQDLVDEKTRLGSTPPSCRHKCNECYPCKAVQVPTLPMHDRIRRGFEPSVPLSLPDDGKMYSNYKPMGWKCKCGSHLFNP
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MSAPSTVAVPKLDSENAVREALSLMKHLDKGELQEIMDSEENLDNILRDLEEIKKIEVNREMLTASNRSLAEFNLKIEPQLNQGRQQLIEAHERREMLQAQFQSNKAKLDTLSDQYSSDTTTALLQTAVAQAEEDSEKTVDTFLDGKMSMEDFIQTFMPQKALHHLRRVKAEKLTELLQQRRSGQCSYKF
The following text describes a protein:
Function:
Probable transporter of a GTP-driven Fe(2+) uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MPVKSLTRRSEISQKIVKVALAGCPNVGKTSLFNALTGTKQYVANWPGVTVEKKEGVFTYKGYTINLIDLPGTYSLGYSSIDEKIARDYLLKGDADLVILVADSVNPEQSLYLLLEILEMEKKVILAMTAIDEAKKTGMKIDRYELQKHLGIPVVFTSSVTGEGLEELKEKIVEYAQKNTILHRMILDYGEKVESEIKKVENFLRDKKLRINPRYFALKYLSGDPEFYSEGVKLGLPELSEEERIGYRLLIAKRKREYVENVVKEAFADAGSKSLSLSEAIDHVLTHKFLSFPLFFALMYLVFKFTFDIAQVFSDLLDLLFSQLGSAVVNTFGENAFTSLISDGIIGGVGSVLVFTPNIFAMFLALGFLEESGYLPRAAFVMDRIMEKFKLSGRAFMSLILGFGCNVPSIMATRAIDDPRERLVTILITPFISCSARLPVYLLILRIFFPESSAAMLFIIYSLSILITLLSSVVINWLFYRGRTSPLILELPRYRMPTLKNLYIYTWNRGKHFLKKAGTIIFVSAILIWVLSYFPAAGDIENSFSAMIGKSLEWIFKPFGYSWKIVTSLFYGAVAKEVVVSTMSMLYGFEEETFLGAKEALSAEMDPVSAIAFLIFVMAYIPCFATIATIYSETGSLKWTLFSIGYSLSIAYVLSLIVFYVGKLVVMLI
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for Rab GTPase Rab-11.1 (By similarity). May spatially and temporally regulate the distribution of Rab-11.1 to target membranes during embryogenesis. May play a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows.
Sequence:
MDETATSSEVTETFVSDPTTRQFEEDGHPPLETRHLNMIHEELEKLNISTDVINKMEVQLDLARADFRETQVQWSEKLKELSKQYSSQIAKARPFYELKIKERSLREESQKAAERFERATSILGIAKQQVSLTQESLSRQTSVLPECLEVLNHHIQRVREVEEERTAAESLHASKAHAMLHLAEKIRAMEKDNRYAIKKSRLYFEKRLEFTKILEAQKATILCLEAEVRQKKNDYTTSLRNLERISERIHEERSTGSLESAVSSDQEDQKSDFKSSESLPGNPPPYAPTAPPPYEDKYIIDKDDDSIVLNMIKTEQEEEGEKRNSRSLGSGVILLAQQLIGNGNSTEKHNITPPRHGEEADISYHTRPVGLSDGSDNSEVSSLASFNIGDDDTVSKMLMSHSELIKDIELATDRVGHILKPNIKSVSNAHE
The following text describes a protein:
Function:
Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSPTRLSHSGKRSWEEPNWMGSPRLLNRDMKTGLSRSLQTLPTDSSAFDTDTFCPPRPKPVARKGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMPLRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEYFPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEVQYERDKHLFIDFLPSVTLGDTVLVAKPHRLAQYDNLWRLSLRPAETARLRALDQADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLEAGVLPSALNPKVNLFAELTPEEIDELGYTLYCSLSEPEVLLQT
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSCSGSGADPEAAPGSAASAPGPAPTVSAPAALPAGTAAENKASPAGTAGGPGAGAAAGGTGPVAARAGEPAERRGAAPVSAGGAAPPEGAMSNGVYVLPSAANGDVKPVVSSTPLVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT
The following text describes a protein:
Function:
Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The 9aaTAD motif (residues 237 to 245) is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MLVFGPNSSFVRHANKKQEDSSIMNEPNGLMDPVLSTTNVSATSSNDNSANNSISSPEYTFGQFSMDSPHRTDATNTPILTATTNTTANNSLMNLKDTASLATNWKWKNSNNAQFVNDGEKQSSNANGKKNGGDKIYSSVATPQALNDELKNLEQLEKVFSPMNPINDSHFNENIELSPHQHATSPKTNLLEAEPSIYSNLFLDARLPNNANSTTGLNDNDYNLDDTNNDNTNSMQSILEDFVSSEEALKFMPDAGRDARRYSEVVTSSFPSMTDSRNSISHSIEFWNLNHKNSSNSKPTQQIIPEGTATTERRGSTISPTTTINNSNPNFKLLDHDVSQALSGYSMDFSKDSGITKPKSISSSLNRISHSSSTTRQQRASLPLIHDIESFANDSVMANPLSDSASFLSEENEDDAFGALNYNSLDATTMSAFDNNVDPFNILKSSPAQDQQFIKPSMMLSDNASAAAKLATSGVDNITPTPAFQRRSYDISMNSSFKILPTSQAHHAAQHHQQQPTKQATVSPNTRRRKSSSVTLSPTISHNNNNGKVPVQPRKRKSITTIDPNNYDKNKPFKCKDCEKAFRRSEHLKRHIRSVHSTERPFACMFCEKKFSRSDNLSQHLKTHKKHGDF
The following text describes a protein:
Function:
As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair.
Miscellaneous:
MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
Sequence:
MITNKKIKISVPEKLGLSEESFEESWETVKYAIDHIYSDDMADLSFEQVYKTIYTIVLNKKGPILYNRLKDYLIQKLALLRETIVKDNTHDYEFLGTMARLWEVQCHCFKITGDLMMYMDKVYCKPNRCMEVYDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSEHTSLWKVLIGMMETLHDNRDSFFLTDFEPVLISATEEYYNKAIDIELLTPIESLEKIRKLRQFESMLDSSFLNVDSHNKLKTVLENVLIWGKLSDIIEDLTHEAMVISNGKLLQEIYDLSSEEKYRVTVIESIKSYINKNAINIPFNEGNRKKGQNAITWSSEIVELYRSQHSFLESIDFGSVRLNNLTGDVSNAILGDVFSMYFSKEGALPSEYLSTYVDHCMKRTKEKDAEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRSLVEIEKWMVQMIKKVLGTFFTSKLEIMLRDISLSSEMYQAFQHSTINSIEYLSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMSTIPRCKILKKSSSSGNMKFSVNYFFSSPNRKVKVPVIACPLPSQKSDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYHYLS
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Subcellular Localization:
Cytoplasm.
Sequence:
MRPQVVGAILRSRAVVSRQPLSRTHIFAAVTVAKSSSPAQNSRRTFSSSFRRLYEPKAEITAEGLELSPPQAVTGGKRTVLPNFWLRDNCRCTKCVNQDTLQRNFNTFAIPSDIHPTKVEATKENVTVQWSDNHTSTYPWPFLSFYLTSNARGHENDQISLWGSEAGSRPPTVSFPRVMASDQGVADLTAMIKEFGFCFVKDTPHDDPDVTRQLLERIAFIRVTHYGGFYDFTPDLAMADTAYTNLALPAHTDTTYFTDPAGLQAFHLLEHKAAPSRPPPPPPPPPPPSEEKEAAGSAAGEAAAAAEGGKSLLVDGFNAARILKEEDPRAYEILSSVRLPWHASGNEGITIAPDKLYPVLELNEDTGELHRVRWNNDDRGVVPFGEKYSPSEWYEAARKWDGILRRKSSELWVQLEPGKPLIFDNWRVLHGRSAFSGIRRICGGYINRDDFISRWRNTNYPRSEVLPRVTG
The following text describes a protein:
Function:
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MKHPMRILQGLKLAAVLAVALSMGACANKNSAADAMANAATPGSQQDFVVNVGDRVFFESDQTDLTPQAIVTLEKQAQWLQTYPRYSFTIEGHADERGTREYNIALGARRAQSVRSFLASRGIDANRMRTISYGKERPVAVCNDISCWSQNRRAVTVLNASS