lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.
Sequence:
MTDTATGVHSNANGVEKVPTPVFSIEGEPTQETAPTRMDPFDRPKNDNDPFEDALKRCHKILEKLDCPFVTGKEKDLDESDDMTENEDHDEMANEDDGIPSNEKKVETRKMDCTSGQLLAPKLPEKAESISSASESSEDSESVAILKYTVRTCYAIWKKRQKNSEIALKGLMIVLELCLSQPSARDDAFSALLETLGYNTVTFWKAVVPQIYNSDLSYATQYREALLFSLVLYDVNHSKNRLRELYAAVPGVRQSMLGIRAKQFGERYRHLQMKIARSRASSRMSSKMGSEENLPAMASMMNDVVFDEEPHTQSPLVDMSHDKQRVINVSNAPPVSISRKTSGSWEIKQGSGGLVACVDPVMSADKKNIWLSNLGVNMQEELKEHSTSTNSLGLPLIKQACAGEVFCVLERNEKKEELTPKQQAVESDMSLLSVLNTYNKHSYQLNPVVVNQDDYNTYYGGISNGLLWPALHNLPQYISPCFDDPELLREQWCAYVRVNYLFAINAARNSRAQDFIWIHDYHLMLCGQIMRSLESSLDIGFFIHIPFQPPANFMTKYKTVADPIMRALLRFTKVGFQTSRDRDTFVKLVAKHIKRTKIEYDSRLDRYTIEHDGWTCSLGVFPVSIKIADFVNIAKNPQTIIEAEEIKKQIMGRSADGGQLFFSVERFDYTKGISEKLRAWQRYFEKYPDRIGKDVLFQVAVTNRRSVDSYRQYQDDVLAVADLINQKFKSEDYPEWKPVIFETDGLPRTRLIAHYLAMDIGVVTPSKDGMNLVAKEMLVCNPTASLVLSTGAGTEVQLSNAQFYSEQEGKCYHRVEEISNTEAFADNFFAAATESKETRTKHGEKINQFLCVHDIDEWSDQFLDPKWTHEVISQCEVKQLGQFYGLMSRTAQVRRQIVECVLKGLPIRPHFRYSLENAKNSLESSCKSGTKLSLEADEESGEEKGFEITYDIHDELSEMEKDLAFLAFIQSDEYENAEEFIKTLGSFYEGGPVLFKNEVKQAAEMLQQGIHYNTFFTDRDGTLKSYACSYPTSVQPAYSAVIQAQFARRCATFCAIVTTAPLLHTGILEVATIPEGYYAYGASAGREWYLNPAQQFKDRSFSAIDLNLMNKVFDIIEELLERPEFRIFKWIGSGIQKHCGHITIAKQDVNGTIPSRKVIRLYEQLVKIVNDFDPNGTTLTMRESDLDFKIYVKAKLKGRIFNKGHGIRLVRERLKPNMSKGNCLVCGDNESDIPMLEECLKLAGSKVYTIWVTADTNLQEKVTQLCDRFSCSNIHFVSCPQVLLGAMAYATAHTLVDERNRKLDYYYDSDTPMDQEESSTLGASLGTSFGN
The following text describes a protein:
Function:
Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSYPYQKSHHQTQQPQQNGHPQHQLMLQQQQQADHSPHHHHHHHVHHATAHAYPYELGRSPLRSPQSPPLYSGKPPPPPPQSYHSYQQPPTAAHPPVSLSGAPTSMPGMMPGQQPPGMTLSLGGGGGGGGGGSAGDCFMLPPLQPQSPDGLSTVTNTSSTATNAPSARSVYPQHHQPSYPSIGSSHHPFHSPASAAALIGPSMPQHAQQQQQHQMQPHHYSSMHLLGPAGGPPSSVGPASMVGMMGPGGHGGGGVGGGAGGIAGGVGGGPGGGMGGGHNYSQSDDDSGCALEEYTWVPPGLRPDQVHLYFSAIPEDKVPYVNSIGERHRVRQLLQQLPPHDNEVRYCHSLTDEERKELKLFSAQRKREALGRGTVKQITTTLICERCGECASSGDMMVFASRFEPNTCWHPACFACCVCKELLVDLIYFHRENRLYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHIKHFACFECDKQLGGQRYIMRDGKPYCLHCFDAMFAEYCDYCSEPIGVDQGQMSHDGQHWHATDQCFACSTCRCSLLGRPFLPRRGEIYCSIACSKGEPPTPSDEYAHRSSQPSHTAARSPEPLRSPERGTGRLSPPHTEHEVQSHEAASTVGSDRDHQLRSPASNGTATDNGTGTAGGGVGDSNRHRIPHRQPLDLTDLGHSLEQHWQSERTGSETISITTATATVRTQVTGPIAGANGNGPTGGGPILTSSMPELNRCLAAAGSGESPSFSGTNSPTPMPIEDSVVANGGDDADEQNQNASDASHSIKEVRFEGDFQDSLPRTKSYCQRNGGQRNRAAKSSSYASDDDELAEDETDNYHHRRHHHSHQREQQRPVDDSDARSVCSTCSSSSSSADDDVYELPLRRTSYGGTRIHYMPNNSLACARKRKQLQTSSGVAGQHYEKDNKNCIIS
The following text describes a protein:
Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Sequence:
MVCHAWRLVLLQNGVRLAHLKNNLQFTPKILRFQGSKDLKKMSSDNLHKRRGDHSSSRASMREKLVEKKKANQEHESNFNAGRVNVQERHLHRTGIRGRKIWCFLAVLYLLALMCIINLIILSIMYSVLQIKTDGMKSLSFFENGMLRWTKKSDLEIVTAYKHEIGGFRDQSLDIESQGKKIILHGGPTTNSPQVHVNSDGSGVFKAKKGFRFEDPYAEKEVITFDGNKVLFLPEYIKGEEIGMNRIISHRIVSDDNNNLTLSASTSMDISGHEGVNMDGKTLTFEANTDVNIISSVSNRMELSAQKVALKPASNSIPSNTNNYKLCVCRTSSKLYAVDSPQNASVTCKTIEKIC
The following text describes a protein:
Function:
Probably part of the carboxysome shell, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. It is thought that this protein controls transport of RuBisCO reactants in and out of the carboxysome; residual densities in the 4 X-ray structures suggest that differing compounds bind in interior pockets, depending on the open or closed state of the pore.
Subcellular Localization:
Carboxysome. Note=This cyanobacterium makes beta-type carboxysomes.
Domain:
Contains 2 BMC domains, trimerizes to give a hexamer. Each trimer forms a pore with an opening of about 13 Angstroms in diameter; depending on the conformation of conserved residues Glu-69 and Arg-70 the pore is open or closed. Dimerization of the trimers forms a small barrel-like compartment, accessible via the pore. Barrels with one open and one closed pore or with 2 closed pores have been seen. A pocket that is the right size to loosely bind RuBisCO substrates and products is found between the 2 BMC domains in each monomer.
Sequence:
MGVELRSYVYLDNLQRQHASYIGTVATGFLTLPGDASVWIEISPGIEINRMMDIALKAAVVRPGVQFIERLYGLMEVHASNQGEVREAGRAVLSALGLTERDRLKPKIVSSQIIRNIDAHQAQLINRQRRGQMLLAGETLYVLEVQPAAYAALAANEAEKAALINILQVSAIGSFGRLFLGGEERDIIAGSRAAVAALENLSGREHPGDRSRE
The following text describes a protein:
Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Subcellular Localization:
Chromosome. Nucleus. Chromosome, centromere.
Sequence:
MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGVRGTGRGRANGHPQQNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMPGPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILQTSKTMLKSSGESGHPCLVPDLSGNSFSFSPLRMMFAVGLSYKAFIMLSGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHKKLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIELMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQIDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALLKQIKFVVEKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTSFHNAHDLTKWDLFGNCYRLLKTGIEHGAMPEQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMGEQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFGMPMF
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular Localization:
Mitochondrion.
Sequence:
SSEENDDKRPPTMQRRTIVQLSRRHPVDWPGTARLRNAAIAYNPRRCFHPALSRLNSSDSSSSSNSDDPSSPSTSQNSAPKFGSRWAPRQTSQPAALSPEEQAIRNALLTKSAAPSSSNTTTGSLGSPQPTPKFGPRWAPRQTSQPAALSPEEQAIRNALLPKTSGSSTSDSPKQDNVPASSTSVSKPGSRWAARQTSPSSTLSPDEQAIRDSLLFRTTRKKERQQDEAPSRRPPGSHRHSGSKTKAPPIDKESRDLQPLKEYEVNGASKLPKALRNQDWVCAECGFRCFGKHSICPMCKARRPGLINPSQGESRFKDWICPNCGFTCFGKHRLCPRCKARRPARNTNSGLTEPSSRDNIAGTSSPSDVKQSRGDTVAGAGINLTTDSPLEASEGSTGDSIEEPFKIRKKFAHDAEPDDGSRQSALRKHMEAKLAQAQEAGEEDLALRRRLKELRAAKRDKQEITELETDTWSPSTERRKSRGEKSRDEHNKKAKRRGGNRERESALEEEFDVDEYHRRREERKKKKKERRSKQADEQELSPLYLPEFISVSNFADVVGMRPAQLVERMEEMGFEDVSYSHVLDAETAGLIAAEFGYEPIVDTGAEQDLTAAPEPEDKSIWPSRPPVVTIMGHVDHGKTTILDWLRKSSVVASEHGGITQHIGAFSVTMPSGKKITFLDTPGHAAFLDMRRRGADVTDIVVLVVAADDSVKPQTVEAIKHATSAKVPIIVAMSKIDKEGINPERVKQDLSSHGIHVEDYGGDVQAIGVSGKTGQGMLELEEAIITLSEVLDHRADPDGFVEGWVIEASTKSYGRVATVLIRRGTLRPGDILVAGNTWARVRTLRNEAGVSISEATPGMPVEIDGWRENPTAGTELLQAEDEQHAKDVVEYRVEREETQRLGQDTAAINEARRDMIEKRRKEASEEEELTEEKLSGPKPINFVVKADVHGSAEAVENSITAIGNNEVYAKVLRSEVGPISESDIELAAAANGHIVCFNMPIDTTMSRMAQNLGVNIMDHNIIYKLVDDVKDTLSEQLAPSITKRVTGGAEVGKIFGISLKGRA
The following text describes a protein:
Function:
Co-chaperone required for the assembly of iron-sulfur [Fe-S] clusters in both mitochondria and cytosol. Required for the activity of iron-sulfur proteins such as aconitase and succinate dehydrogenase. Involved in iron homeostasis and may take part in the control of iron translocation from roots to shoots.
Subcellular Localization:
Mitochondrion. Cytoplasm, cytosol.
Sequence:
MKKTKTMVASISTLIRRTYPSTNQCNSLATIQSQTQLPRESLQHHSSAEGRLRFSGRVFCSESGAGCWNCGEKAAFLFCNSCRSIQPVDDSVDYFQIFGLEKKYEIDPGSLEGKYKDWQKKLHPDLVHNKSKKERDYAAEQSAKVTEACRTLTKRLSRAMYIMKLNGVNVNEEETITDPTLLMEIMELREAISEADDSTSLNQIRSQVQEKLKQWSDSFVEAFESQKFDDAVKCIQRMTYYERACEEILKKL
The following text describes a protein:
Function:
Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending.
Subcellular Localization:
Secreted. Target cell membrane.
Sequence:
MKAISLLILVGFIGEFQVFSSASSPVNCQWASYGPWSECSGCTKTQTRRRSIAVYGQYGGHPCVGSAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCEEDSADEDRCEDSESRPSCDLDKPPPNIELTGNGYNALTGQFKNRVINTKSFGGQCRKVFSGDRKDFYRLSGNILSYTFQVKIDNDFNYEFYNSSWSYVKHTSTERTSSSRRRFFFSSSSSSSHSYTSHKDEIHNKKSYQLLVIQNTVEVAQFINNNPEFLQLAEPFWKELSYLPSLYDYSAYRRLIDRYGTHYLQSGSLGGEYKVLFYVDSEKMKQSGISSADEMECTSSDVNLIFKSSKHKCQALKEALKSAAGTEGNVLRGKPFVRGGSAGFVSGLSYLELDNPAGNKNRYSSWAGSVTDLPQVIKQKLTPLYELVKEVPCASVKRLYLKRALEEYLDEFDPCHCQPCQNGGIATVEGTQCQCHCKPYTFGVACEQGVLVGDQAGGVDGDWSCWSSWGPCVQGKKTRRRECNNPPPSRGGKSCIGETSESRQCEDEELKHFRLLEPHCFPLSLVPTEFCSSPPALKDGFVQDEGAMFPVGKNIVYTCNEGYSLVGDPVARCGEDLQWLVGKMHCQKIACVLPALTDGIQSHPHKPFYTVGEKVTFSCSGGMSLEGPSAFLCGSSLKWSPEIKNVRCVQKGAPSTHTVPACQRWEKLKNSRCVCKMPYECGSSLDVCARDEKTKRILPLTVCKMHVLRCQGRNYTLTGRESCSLPASAEKACGVCPLWGKCDDQSSKCVCREASECEEEGFSVCVEVNGKEQTMTECEAGTLRCGGQSISVTSITPCAAGTQ
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYKTISLLTLKYLKWTKLLNYNTVTSSLHITMTFKLLRILFKIGNCLAITPKNFKLRKPTILEKILGCFMLIFQTVTAITSVAYKLPQYSQYIYIKLTVYVILDVSLYLFSVTAVLSGLFKRNQWYKLVKNLMLTGKDPTTGHKKYFGFIVVNVIFLAMMVYLNVVFGTDFVKRFTLNFFKLYVQFFINYLVYAILQILKMRYRSLAQSLENEANIRDTTLKRVSYDYILLKESVSIFNNIFGWLILFNTIHSSLQIVVYPSDTFLSSRIEWILADIFVLIIFCGGIVITIISCDLVLSESEKILSISLKHLEASPDNRNLLKFIEMALANFPKFSAARFFSISRTTILRILNATVTFLIVVIQFQINVQKL
The following text describes a protein:
Function:
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQGSALPVLGAGGWGTALAVAAARAGQPARLWARRPDFAARLAEVRENREYLPGVLLPPEVAVTSDLPGAVAGADFALLVVPSVGVPELLAGLPRELGVVLCAKGLAPDGSRLSEYAAGLGFDRVAVLSGPNHAEEIGRGLPAATVVASRDPALAAAVQTALMSPSLRVYTSRDVPGVELGGVLKNVIAVAAGMGDGLHLGDNAKATLLTRGLREMNRYLRSLGAEEETVYGLSGLGDLIATATSPHSRNRAAGEAIARGESPQQGGKVVEGLRTAGLLDAWAAAHGHDLPIVRAVAQVTRGEWSPAEGVRHLMGREAKGETEAGEP
The following text describes a protein:
Function:
Probable oxidoreductase.
Sequence:
MDLQYRFNQLDFESNAQDITVSLNSLSFNHSLSNEEKKYLCLRPRHHAFAVTTCAHAVYIVSTLNEMRQVLSEIRHPINQKTIQFLHQSPPRDALKIGFIGCGRLGKQIVLSMLKFTDVKPNELYISTRRPESLGSFQKVGVNCFHDNKEVVRRCDVIFLCCLPSQIPVVADDITGHIRPNSLFMSFVTGVPLHRLRQMFQHNNISKTEFTWSMKNANHRWCIGETVNLALEKDWIANTVSPNIGNVKMSGIVWSSTKIIETVLYTAINMCPSLHLTTNEVLQLLNIVFLSKLDSCTSKLTWKHILNDDSLAVVNQGNLPVFDISHVAMHDTPMTLFFKSENEQQLHQMILNKFTSIFTKFKQS
The following text describes a protein:
Function:
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Promotes the sumoylation of host ZBED1/hDREF with SUMO1 (By similarity).
Subcellular Localization:
Host nucleus.
Sequence:
MRTEMTPLVLSYQEADDILEHLVDNFFNEVPSDDDLYVPSLYELYDLDVESAGEDNNEQAVNEFFPESLILAASEGLFLPEPPVLSPVCEPIGGECMPQLHPEDMDLLCYEMGFPCSDSEDEQDENGMAHVSASAAAAAADREREEFQLDHPELPGHNCKSCEHHRNSTGNTDLMCSLCYLRAYNMFIYSPVSDNEPEPNSTLDGDERPSPPKLGSAVPEGVIKPVPQRVTGRRRCAVESILDLIQEEEREQTVPVDLSVKRPRCN
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTVNYQLDVSSGNPLLFLKLLSRWRGSIWKSVAGDLAVWLVFFYAVHFTYLYVLLKDWQLIFDKISIHMDDRMKYLPLTFMLGFFVTTVFERWRSALNVMPFIESVALSVAVLLPGKGEEDRLTRRAIVRYVVLHQVLVFRDISMRVRRRFPTLQYVVDAGFMEPEERDELEAVCCNPGQNYWVPINWANSLALDAHQRKLIDQPTAFNNLILAIKEFRVSMETLIKFDSIPIPIAYPQVVFLAVRVYFTICIVSRQFLISDLKSKTQMDWPVPIMSILEFIFVIGWMKVAEVLLNPLGEDDDDFEVNWIIDKNISVSSFLPEMIVIFLKFQTGMAIVDNTHGYHPNLVNDKFADPDYLPAYSEKSQLPRTLTGSAAKVELASPDDAVKIVRVNPEDAPPTSERGSIFTKRNAFSLRNRTISISSNNIESPSQERKFNLSMPATMLSKSKQPDRPGLETLNEENEPASNNHFRRGDRIYSSDSVNALN
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MEIKPSRIFSTITIFFLCLLLAHVTSKASSSSLCNGSVAECSSMVETEEMSVIMESWSSQRLTEEQAHKLSYGALRRNQPACDGGKRGESYSTQCLPPPSNPYSRGCSKHYRCGRDS
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MSKLRSCCVPCCNEEKFSLVHKFPSDNERAEQWRRVLAIDGFVGLSIDVIRKRFFICTRHFRDSDYKNEASRSLNITAVPSINLVTLNDPEGLNRDPPPLNRPGTMLPVGQGLAEPKDGQESGRQEQTANTSTVSPGLNAYVEESCPEVSQFATTYGDDIEFINVPSSDAFRKPSQGSPSTVSLKRAFPKPIPSPGTLNTISLIEPRVKVPPTRANNVLRRTIVTKPAYSNIVPLGVPPEGAPLVLRRIKGPVPMVERKKCTSTMTQTDDTAVEEPADKPPGQTVGEQDDKDVKANQPATKVLALLECTPENLQRLQRKLEAEGGALCLDERLLRLDGDDEAERDKAMQSNKQDGTADPTRFLTVWTDPKEGESISVSYVWLRDHCQCEECYNVATFQRSTSILDLPLDIQPALCNVTDSKIEIVWQDGHLSSYQLRQVVDNHVDNYRKRLEERRAQLVLWDRALIAAAEHSPSYARVTLNDLLCEDSVMRQVVGSLITYGFAFITKVPPNQQSTEMAVKRIFPVQRTLFGDMWTFSESKMDHSDTAYTNGFLGPHTDNTYFSDAAGLQVLHCIQFNGRGGETLLVDGYAAAERLRESDPAAYDRLCEYPLEAEYIEEDKHHRYMAPVIKRHRVLTGAVEQIRFNPYDRAPMRTLAAAEVPQFYADYRKLAEELYREEVQWKFQLTPGTVLIFDNWRVLHGRMAYSGKRVMTGCYVARTEYQSVARTMGLIE
The following text describes a protein:
Function:
Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis.
Miscellaneous:
MISCELLANEOUS: Present with 688 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nuclear in G1, cytoplasmic in S, G2 and M cell cycle phases.
Sequence:
MDTSNSWFDASKVQSLNFDLQTNSYYSNARGSDPSSYAIEGEYKTLATDDLGNILNLNYGETNEVIMNEINDLNLPLGPLSDEKSVKVSTFSELIGNDWQSMNFDLENNSREVTLNATSLLNENRLNQDSGMTVYQKTMSDKPHDEKKISMADNLLSTINKSEINKGFDRNLGELLLQQQQELREQLRAQQEANKKLELELKQTQYKQQQLQATLENSDGPQFLSPKRKISPASENVEDVYANSLSPMISPPMSNTSFTGSPSRRNNRQKYCLQRKNSSGTVGPLCFQELNEGFNDSLISPKKIRSNPNENLSSKTKFITPFTPKSRVSSATSNSANITPNNLRLDFKINVEDQESEYSEKPLGLGIELLGKPGPSPTKSVSLKSASVDIMPTIPGSVNNTPSVNKVSLSSSYIDQYTPRGKQLHFSSISENALGINAATPHLKPPSQQARHREGVFNDLDPNVLTKNTDNEGDDNEENEPESRFVISETPSPVLKSQSKYEGRSPQFGTHIKEINTYTTNSPSKITRKLTTLPRGSIDKYVKEMPDKTFECLFPGCTKTFKRRYNIRSHIQTHLEDRPYSCDHPGCDKAFVRNHDLIRHKKSHQEKAYACPCGKKFNREDALVVHRSRMICSGGKKYENVVIKRSPRKRGRPRKDGTSSVSSSPIKENINKDHNGQLMFKLEDQLRRERSYDGNGTGIMVSPMKTNQR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MPPKILEQVRNGATDAFSHMPDFSFNAEAAKELSGHLEKLGSDDGPVQFPLAFESVEEKVNFLAIYALLSFGSGFRKELHEFAQRGAQDTTLFLAMTMYMTKKPGLLDADFLSNVTVSDIAEWAGVPLRIEKPCEGLSSSAITELVDSDLKPWVENMAHVLVETGTILKQLDCQSLGAFCLEYANPNDSNELVERLCMCFPAFQDVGRLDGQLVYILKKAMLAVYMLHNAYPDRFSCEGLSVFADNVLPSILVYFHVLEIPESLRSKLENLQPLTDKEALQLRTATVHICNLIANETNISPVKIDQRLWKYSKSNPELRKLPRFLKKDTVMF
The following text describes a protein:
Function:
Plays a role in cell-cell adhesion during embryonic development. Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGSWLVDSNLDSRMGAACFLLVSGFLSLQLPPSGCQQSAGPVNPFPMPMPGSASMGGQGGELLPHFLIEPESVYIVKNKPVTLNCKATPATQIYFKCNGEWVHQTDHVIQHSADRSTGLPVMEVRIDISRQQVEKIFGMDEYWCHCVAWSSSGTSKSQKAFVRIAYLRKNFEQEPLSREVSLDQEVMLLCQPPEGIPPAEVEWLKNEEILDPEVDSNIFIGSDNSLLLRQARLADTGNYTCVAKNIVARRRSNSAAITVYVNGGWSSWADWSPCSTTCGRGWQKRSRSCTNPTPLNGGSFCEGQNIQKTACTTLCPVSGGWAEWSYWSACASDCTHWRSRDCTQPAPRNGGPQCQGPDMETRNCTSELCINTLIMPFNTVKSNIAVGAPEDVALYVGVVAVAVFVVLLLAVILVCWRRKEGLDADVADSSILTAAFQPVSLKPGKAGQAHLLTIQPDLSTATMTYQGSLCLRQDGGNKFQLTNGHLLSPMGPGIPREHSHTLPRLSTQSYYRTLPRGSNNMAYGTFNFLGGRLRIPNTGLSLLIPPDAIPRGKIYEIYLTLHKQEDVRLPLAGCQTLLGPIISCGPPGVLLTQPVVVVMDHCVEPSLENWTVRLKKQSCEGSWEDVLQLDGGSPSHHYYCHLESRRCYLFTEQLGRFALVGESLSMSATKRLKLLLFAPPCCTTLEYSMRVYCINDTQDAIKEVIHHEKQQGGQLMDEPRLLHFKDSYHNLRLSVHDMHSTQWKSKLLASYQEIPFYHIWNGSHQNLHCTFTLERFSLSTWDLSCRIWMWQVEGDGQSFNINVNLSKEHRPSEISLEEGEKEAAALVGPNAFKIPFLMRQKIITSLDEPSSHGADWRILAQKLNLDSHLGFFISKSSPTAILLNFWEAQNFPNGNLTQLAAVVAEIGKQDSLLYMMSEAEC
The following text describes a protein:
Function:
Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MCRLLGGTVARDEFEKYDKVQKMRETLVSVLREKFAHFNLTFSIGGQISFDVLPQGWDKTYCLRYLEEFNEIHFFGDKTYKVLTCLKLSYHVRANIRVLLYMESLLVKAPIGVCHQSPFPGLRNLVRDAAVFGDTNLELPSFLSNRSLVEVHLEVGTNLTSQQKDELEIHMELPLHARYQ
The following text describes a protein:
Function:
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Sequence:
MLRYLTAGESHGPQLTAIIEGLPAGLKISDESINCDLARRQCGYGRGGRMKIERDEAQILSGVRWGETIGSPVTLCIVNRDWINWQEKMSPNARHRDEKIRVTRSRPGHADLPGAMKYDHRDVRNILERSSARETAVRVAVGAVAKAFLASFGIEVNGFVSEVGGIRAERRSLQLERMKELSAASELFTYDAEAEERMKAFIDGAREAGDTVGGVVEIIASGLPVGLGSHVQWDRKLDARLAMAVMSIQAIKGVEIGLGFDAARRPGSQVHDEIYYDSTRISRGELSGFYRKSNNAGGIEGGITNGEDIVIRAAMKPIPTLYRPLRSVDMQTKEPFEATVERSDVCAVPAAAVVAEAVVALELANAMLEKFGGDSLGEVRRNYEGYLEYVRAF
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Coodinates SWR1-C, FRI-C (FLC transcription activator complex), histone methyltransferase and general transcription factors. Represses flowering by positively regulating FLC and MAF4. Binds to the promoter region of FLC chromatin.
Subcellular Localization:
Nucleus speckle. Nucleus. Note=Relocates to the nuclear periphery when interacting with ARP6.
Sequence:
MEEEMSNRRVSNRTRKVATKMAAALTSNDNRTQAAIARLEALENDNGAIEVIDLNDDEEASLDEDDDLGYLQKKQHKGSKRKTRQAKALEARKAPKSFLELLQEANLESLPSHVPTYLKAAVGPPSSSSRRYFCSVCGYIAGYNCCLCGMRFCSIRCQNIHKDTRCQKFVA
The following text describes a protein:
Function:
Maybe involved in N-terminal acetylation of proteins. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.
Miscellaneous:
MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MMVPRISASPVFKRIFLRWGFVTLPIQKTVSHTLRRDFSAPCRSMVKCLLLRPGISVHSAQDRKFYSTEEKSSQFDENKSKSNNGKKNEPHGIKGLMAKYGYSALIVYILLTCVDLPLCFLGVHSLGEEKIKIYLNRGKQLIGMGEPDESKVIQDVRRKQAHREAVQAENADKVEDASRKTFNERWQEMKDSTLLAELLIAYGIHKSLIIVRVPLTAVLTPSFVKLLQRFGIDLMKKQKKVFQTMASGAKIRYKGNNPSDFIKNEGTALDITKRKPRTKGQKWFDGLM
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
GKERTFRCRQCGHVAQSKTDFWEHSKVHIKTEKLLSCPKCPFVTEYKHHLEYHLRNHFGSKPFKCPKCNYSCVNKSMLNSHLKSHSNVYQYRCADCTYATKYCHSLKLHLRKYMHRPAGVLNNDGSPNLFPVLDVYGTRRGPRRGPRPDIQLQPPLQNHLQNQFQNQFQNQLQNQLQGPLQGLLPAVACAQQQLLRAAVLGSPGVVPWKCSVCDYTTADEQQLSRHVLSHAEGQDLYVKEDVKEERIEERKEDRKGFPLDLSRGPVEPSRSRRKGRAFRLDRLCLRLQENEGDVETPRAEDPPEVPSPVAPQQKLSPPSILAARLQESPPTETSVDGSPPAKDAYRCVYCDIAFEHCVMYTVHMGYHGYHDPFTCNMCGQRSEDKLAFFLHIARAAHL
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles.
Subcellular Localization:
Nucleus.
Sequence:
MRIEKCYFCSGPIYPGHGMTFFRNDCKVFRFCKSKCHKKFKKKHNPHKVRWTKAFQKAAGKELTVDNSFQFEKCRNEPIKYQRELWNKTIDTMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDIKEVKQNIHLIRAPLAGKGKQLEEKMVQQLQEDMDVEDAP