lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
Sequence:
MFTGIVEEIGVVKSVQIRQSVRTIEIEAHKITADMHIGDSISVNGACLTVIDFNQTSFTVQVIKGTENKTYLADVKRQSEVNLERAMSGNGRFGGHFVLGHVDELGTVSKINETANAKIITIQCSQHINNQLVKQGSITVDGVSLTVFDKHDNSFDIHLIPETRRSTILSSKKLGDKVHLETDVLFKYVENILNKDKDQLSVDKLRAFGF
The following text describes a protein:
Function:
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Subcellular Localization:
Mitochondrion.
Sequence:
MNKILKNIINKSSINNVFKTSFNGGISSSSSSSSSYLNNNNNIIKSYNVQQKQQQRYYSSFEDDLSPKKLKEKILENETEEIRDFVRSQRLTKKTASPLEGMNRKERRKMTTKLYRNPDNLIRGGIVSPQPLIPAHIKKPKYVLGEPVIDFEIDDPIEIHTAESIEHMRVVGKMAKEVLEYAGTLVRPGITTDEIDKLVHQNIIDRGAYPSPLGYKGFPKSICTSINEVLCHGIPDDRPLEFGDIVKIDVTLYYNGYHGDTCATFPVGEIDSSSKRLIEATEKALYAAIGEVKDGALFNKIGKKIQLVANKYSLSVTPEFTGHGIGQLFHTAPFVFQCANEFDSVMKEGMIFTIEPVLVESTSPYAEWKMWDDKWTVSSREGGWSAQFEHTILVTKDGYEILTK
The following text describes a protein:
Function:
May be involved in membrane trafficking in the early secretory pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAETSGPQSSHISSSSVGEKGSGCAVRDLLYWRDVKQSGMVFGGTMVLLLSLAAFSIISVISYLVLSLLTVTISYRVYKSVLQAVQKTDEGHPFKPLLEKDITLSSDSFQKALTASLAHVNHALKYIVRLFLVDDLVDSLKLALLMWLMTYVGAVFNGITLLILGVLLTFTAPIVYEKYKVQIDHYVSLVHSQVKSITEKIQAKLPGALKKKSE
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MFGESSISGVKAEASPSTLIVQAKDSLQNGCMKKPFRCPLCEYKTERRRLLSDHLDAHLDKQRQYKCKYCDFFSFHKRVLSLHRAQCTFVQNKIACPHCEYVTAKHRSLKKHIETKHVQNRAFRCRKCRFKTESREEFEVHKVESHVKAKLCYKCEECEFESANKLGLKRHQRGHRVVVGKETIYKCDLCDYESKYNQNVVRHRTKHVEEEILNDS
The following text describes a protein:
Function:
Plays a role in carbon allocation, including during senescence and stresses, thus impacting starch accumulation.
Sequence:
MSFRKVEKKPTEMGRNMTHEKSDSDSDNEGAPMTVGGYTEFVARSDSDWDEPVYSGKARSNYNLTGTAKGTGPINSFSRKHFPNY
The following text describes a protein:
Function:
Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSSRPPCDSVPSRGPENQSKQVQWASVIQRSTSVEGHSKPQLDSSKAPGPGKARRPSRLTVKYDRGQLQTWLETEEWVDAQLQELYQERAMPSVPEFDLEDFIELSSEEQKSKLQAILQECPSHTEPFITELLHRLKKLRRLSRPQK
The following text describes a protein:
Function:
Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.
Miscellaneous:
MISCELLANEOUS: Present with 1580 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MVKGSVHLWGKDGKASLISVDSIALVWFIKLCTSEEAKSMVAGLQIVFSNNTDLSSDGKLPVLILDNGTKVSGYVNIVQFLHKNICTSKYEKGTDYEEDLAIVRKKDRLLEYSLLNYVDVEISRLTDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQLRSQARENCEEIIGSLTLEDDEEFVESKAMESASQLAQSKTFKIAHKNKIKGKQELQQVKYNLQFDNRLQSCVSNWLAARKKLDDSVILSSDLLFLANLYVQLGLPDGNRIRSKLEQTFGSELLNSMSNKIDDFVHRPSNNLEQRDPQFREQGNVVMSLYNLACKYI
The following text describes a protein:
Function:
Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGDGKLFCGKELTTAVWPYPKMAEGCTRFEGSMSQPVVTPNLPLRRPTSSPIIKSSQLEVEIESSLTGGKNFQFSLASEEYLGNKSHGTAPREETNQNGNGSLSTEGISFTKSLGSPGTVKICHVCHQKGFMRCTRCKQTTYCSVSCQREDWKTHRHVCKPYSQKSSKNQQGQPTTTSEAKEMITIGKEQEKKMYLSDLQKMDIKKGLKVQACVVEFRNPGKFFIHIQTAKMIETLKKVTLTLQKIYSNSISEDDYIPDVEEVCAAQYSQDQNWYRCLVQSLDISSRTANVIYIDFGNEEDVKLDKIKRLSVDIDPVPPCALQCRVANLAAVTGSWVEVCCSSVRQLLLGKTCLVTIVDVSETDSVCSVDVALPSIGMQLEEFLVQQGYVVKQKVGKSSPNGQDINSILCAALENFRKKASTGVEDDKKFPEPVHLCIGDSFSCVVTHILSPHDFVIQKLDNAGAIQELQIRLRDHCVQIPSSEDYRPAPGTVCCSQFTEDNLWYRATVLGYSSEDRVFVGYIDFGNSEELELNRLRPANEEFLKLPMQAITCSLPGIKPVSEEWDSESILVMKKLVNTKFLKVRILDKVDVKALVELTDEYSDPQTNIADLMVAMRCAVIDLDFRSQTDQTEGTKESFTKKLEWTSTELPSNETVDVVVSVIDSPSEFYCQCCNPKDLQALNEMSANLLKCSQKASEAFTPVIGEPCCAVFPGDGNWYRGMINDIGPKGAEVYFVDYGNTSEVAVDKLCAILPEYLMLPFQAIKCWLAGVEPVQREWTKDAIKRFQALTVGVQLKAKVLCNGQNGYGIKLVKRGQNVAEKLVAEKLAVCNKTFHDPVLTSIMPGTEPTGGYFPKDWKTVELPKSGTFQLHIVAVRNPSLFYGLKDSNEVDVKKLEALMAELSSYCNKQSYNPNLKPEAGVACCAQFSGDKNWYRAIVLDICDSEAYVLYADYGNIEKVPLSSILPITAKHLELPFQIIKCQLSEELFPDEWSSISLECFESLLRGKVMASVRKFDGKIYTVHLTVCSDNGNVDVSKMMIEKFGKIKCETDAGVIVTDTNVKALLESNTTCTPPIDSQPTNVMKCCCQELKEKIDKLEELLLVVIKEIVHPQKNY
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MCSIGEDDFGDEGATHAMLPGSSTVGTVITAGSCNKCGLNSLELYKLNFRAAECHQCFLSYARHKFRAALGAAKALPRNAEVLLLVDGSAESLVLLDMLHFAQTQNTFKRLHCSARVLHIDAQSSPSENDPLPMLNELRERYAPFEFYVIQLGAEVHSLKLLKDYSASRLDSTDNKLRSLTARQDYVRQQRKRLIGAVALQLQCTHVFEPSISSSLAAQLLTSVALGRGGSVALDVALLDDRLQGAVTLLRPLKDLNEQEVQFYIKAQQLKPFRSDESSLLSDASLQNLTSAFVANLQLNYASTVSTVFRTGDKIAAKRQPIEEGPSTCALCQSDLDSGLSDTLLAIEYSRAVSEMGVALQQQNNMEALEQRARERLNSMDNLCHACRNIHAELTHGSLI
The following text describes a protein:
Function:
Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin.
Subcellular Localization:
Host membrane. Secreted. Note=Delivered to the target cell periplasm by the H1 type VI (H1-T6SS) secretion system.
Sequence:
MDSLDQCIVNACKNSWDKSYLAGTPNKDNCSGFVQSVAAELGVPMPRGNANAMVDGLEQSWTKLASGAEAAQKAAQGFLVIAGLKGRTYGHVAVVISGPLYRQKYPMCWCGSIAGAVGQSQGLKSVGQVWNRTDRDRLNYYVYSLASCSLPRAS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MTESRWYSTSPPAKLNLFLELLARRDDGFHELDTVMVAIDWRDELHVRRTTNPGVQLSVDWTDGRTSVAAELQVDEDNELLLVPTDDKNLVVRALNRLTETLRLDGGWEVQLNKNIPSGAGMGGASSDAASALQLGWAAARETQSDLPETLKNETLLSLAAEIGSDVPFFLGDLQADRLVQCAHATGRGEKLNFFTLANPLHAVVIYPAASVSTAQVYSRCQVPDSPQSSNELLRALQGIAAESEFSLHNALQAPARGLSSRIDPALECLSKAGLTHCHMTGSGSACFALADSSQQAAIAAETLRSTFPGGALIRPVMSCVVPSEIHIA
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted.
Sequence:
MKCFTSLTALTAIFAQASASVIPAIRSPATQPKNGASCVHSATSRSCWGDYSIDTDWYDVIPHTGVTREYWLSVENSTITPDGYTRSAMTFNGTAPGPAIIADWGDNLVIHVTNNLQHNGTAIHFHGIRQKGSLEYDGVPGVTQCPIAPGDTLTYKFQATQYGTTWYHSHFSLQYADGLFGPLIINGPATADYDEDLGVMFLGDWAHQTVFDIWDAARAGTRPSLQNTLMNGTNSCECDTSDPKCVGGGKKFEAVFVEGQKYRIRLINVGIDSHFEFAIDGHTLTVIANDLVPIVPYTTDTLLIGIGQRYDVIVEANATPDNYWIRGNWGTACAPNLQAANATGILRYNSSSTAEPTSVGVTPRGTCADEPLASLVPHLAMDVGSYALMDEKLDWVRGNILTWTINSSSLVLDWTNPTTLQVFRNESLFPTDYNVVPINKEIANGDDWIVYVIEDLTHSGTWHPMHLHGHDFFIVGQEAAVFDPVNTPATFNLNNPPRRDVAALPAGGYLAIAFKLDNPGSWLLHCHIAWHASEGLAMQFVESESSIAIGMKDTEIFDNTCKNWNAYVPTEVFPQDDSGI
The following text describes a protein:
Function:
3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNNAQNKRSLDDSNGNDTKRPKQEDPKYILPKQVNTYPATLPERKKNIEYILNILTKKQPNITNPKLKAIDIEYEIAKKSTNATYKTVFRQEVFKLTKPTKSPSQLSPQQEHLKKLDQEAKELKILKEMVVSRKTLIAFGYIMEPPESIPNEKITRICNRCGTEFRLDQQLQPIVCEFHHGKKQRGKYICCMSNVDGQPCSKAKNHVYLLNTPEEKQALLPYQFTKELFTTTSTKSKSRVLGIDCEMGFTTKGFELMRITAIDYFTSKTVLDIFIKPIGEIVDFNTRYSGIHELTDDFLSWEQSMEKLGEIMDSETILIGHGLENDMNAMRLIHENIIDTSILFPNKWKTGPTRRWSLKDLAFEFLSRRIQTGEHDSCEDSIAAIDIVKYFVKKRLQSIGSSS
The following text describes a protein:
Function:
Transcription factor that confers fluconazole resistance in S.cerevisiae by activation of the PDR5 gene. Can also activate the transcription of S.cerevisiae genes involved in 4-nitroquinoline-N-oxide resistance.
Subcellular Localization:
Nucleus.
Sequence:
MNFKTENSTTPNGDWSQSKAFTNSGSSFPVLNGTCELDQENLALSNSGQPESIFTQDSGLHGIDVAAPSDITDLNNQSGYQYNNNLAHDLYFTGSMEMPTTQHPYITNTNNHLSYSNSSEEFSPIGNNMSPDSTGGANSNNFTSGNKRKASNESFSPLSGHHYGTESGNNNNNNGTSRSSQSSSHKSRKKLLDEKDAALIARDDSELTEEELQMKRKAQNRAAQRAFRERKESKLKELEAKLLASEEERQKLLDELEQIKKQNISIATENEILKHNGMGNINNDVQIGNLSSYGRLQVDKFNFPKTQKDFIEHVLQGTNHQLKDENKDKVYNDNQGHKLLALGAVWDYLQIKAEEADLDFNSIDFNDVMEKLKGNEKCHGYGPAYPLELVNEAIESSLN
The following text describes a protein:
Function:
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
Sequence:
MDKPYHVKFYSYNFPLPKPVVTAHGHWQRRRGLIVELTDQRGNRGRGEIAPLPWFGTEDLASATDFCRSLKGRITPAQIEKIGDRLPCCGFAFGSAEWELESGSVIENSPNSLSYCQLLPTGEAALDYLASNPQLGASTFKWKIGVGDFAVERDLYGQLWRRLPEGCQIRLDANGGLSVDIAQQWLTLLDRQRENSGPKIQYLEQPLPPGEIDEMFRLQEDFATSIALDEAVCSLAQLAQLYDKGWSGLYILKAAIMGNPRVLNHWLKTHPIPAIFSSVFETAIARGQVLALAQKWNLPDHAVGFAPLREPITEATPDSV
The following text describes a protein:
Function:
Exhibits selective intermembrane transfer of ceramide-1-phosphate (C1P) and phytoceramide-1-phosphate. Does not transport ceramide (Cer) or GalCer, suggesting a requirement for phosphate in the headgroup for functionality. Transports in vitro sphingosine, but not glycosphingolipids. Also has some in vitro activity with sphingomyelin, a lipid not detected in plant tissues. The transport function may be not directly involved in regulating cell death. Rather, perturbations in the function of ACD11 or related components could be monitored by R-proteins, which then mediate defense and programmed cell death (PCD), as proposed in the guard hypothesis (Probable). C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis.
Miscellaneous:
MISCELLANEOUS: The clustered Lys-64/Arg-99/Arg-103 residues form a positively charged triad ideally arranged for binding phosphate, explaining the inability to bind sugar headgroups and transfer glycoproteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MADSEADKPLRKISAAFKKLAIIVNSPNPEVPVTQFSHACSLVSPLFGCLGIAFKFAEMDYVAKVDDLVRASSSISTLVVMMDKDIEADCVRKAGSHTRNLLRVKRGLDMVKVLFEQIIASEGDNSLKDPATKSYAQVFAPHHGWAIRKAVSLGMYALPTRAHLLNMLKEDEAAAKIHMQSYVNSSAPLITYLDNLFLSKQLGIDW
The following text describes a protein:
Function:
Participates in viral evasion from HLA class I-restricted T-cell immunity. Associates with host TAP1 and TAP2 and prevents TAP-mediated peptide transport and subsequent loading.
Subcellular Localization:
Host endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MVHVLERALLEQQSSACGLPGSSTETRPSHPCPEDPDVSRLRLLLVVLCVLFGLLCLLLI
The following text describes a protein:
Function:
May be involved in arbuscular mycorrhizal (AM) symbiosis with AM fungi and in nitrogen-fixing rhizobial bacteria symbiosis leading to the formation of root nodules.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDRLVKTEFNEVNLNFQKNQKCSSSFKLTNLMHTMSVAVSLTTTNPTTFSINKPLSVIPPLSSSTYTLHLTNLNQPPLSEPADVITVRTSMLPTGKATTDDLRRLFNKPGPHVFRDAVITVILVGPTVAEYVISNYETRNLFTKAISVCTKSNLTNLMKPAVESGKVEYVTDLITAGGDVNFRDSNGKSLIPFAIRTGKLAVLKLLVANGCRINDSVDFVLHEAAIIDRVDVVKFLFESFCDELDVNSVNREMMTPIHVSASEGHVSLIEFFVSIGGNANAVDSRRWTPLHHAASRNHLKAVEFLLENSDVKYARELNGKTAFEIASESGHTRLFGVLRWGDALLQAARVDDVHALKKCLGEGAEVNRKDQNGWTPLHWASFKGRIKSVKVLLEHGAEVDSVDDAGYTPLHCAAEAGHLQVALVLIAHGGCQTNLKSFQHVSPIATFQKHVSLHYSTKKSETFA
The following text describes a protein:
Function:
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MVLNCAYPGCLNLFKKERLRSNSSSHGGKLTFHRFPTLEPGRLLLWRAALGMDPDTPMRSLRVWRICSEHFSPEDFRAVNGNKVLLKASAVPRVYSTPAPGSRAESAQAMQDCKEEETELLVSEAEGVSESRPQLHHSYTLPAAQSMHADEPSKREEHPEGRPDLNIIKLPSCSPSAKDGVGFPYTSRPAAHTHTAAAAGSSEKLVLKERQWIVSESSVMDLFRRCQQCGALITDTRTVISGCLLRVYWECAQRHIGQWNSCSGIQALLSNLCQKALEPPRHSAEIRRGVRR
The following text describes a protein:
Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSGFARRLGGIPWREIAGEAFSRVFLVAQAVCAVHVVNAHVCSFALVMGPSMLPAMNLAGDVVAVDLVSARLGRVASGDAVLLVSPENPRKAVVKRVVGMEGDAVTFLVDPGNSDASKTVVVPKGHVWVQGDNIYASRDSRQFGPVPYGLITGKIFCRVWPLKDFGPIDPMSAE
The following text describes a protein:
Function:
Functions in chloroplast biogenesis and chloroplast division. Required for plastid development during embryogenesis. Might be involved in chaperone functions or play a structural role in the thylakoid FtsH complex.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MTFYISSSLTPTHFSKPLNPSNTLFPSQFRGSLSSFVRRRKPTEAKLSSKFNLFPSRRNGLITCCSTSSFESTESSVSQEEDAESNRLFEKLRETERERLSNMEELERKANVQLERQLVMASDWSRTLLTMRGKLKGTEWDPETSHRINFSDFMKLLDSNSVQYMEYSNYGQTISVILPYYKDGEPLGEEEDSKKEIIFRRHIVDRMPIDGWNDVWKKLHQQIVNVEVFNVDVVPAEVYTTVATFVVWSMRLALFVSLYVWIDSITRPIYAKLIPCDLGTPTKKIRQPLKRQALGSLGKSRAKFISAEEKTGVTFDDFAGQEYIKRELQEIVRILKNDEEFQNKGIYCPKGVLLHGPPGTGKTLLAKAIAGEAGLPFFAANGTDFVEMFVGVAASRVKDLFASSRSYAPSIIFIDEIDAIGSKRGGPDIGGGGAEREQGLLQILTEMDGFKVTTSQVLVIGATNRLDILDPALLRKGRFDKIIRVGLPSKDGRLAILKVHARNKFFRSEDEKEELLQEVAENTEDFTGAELQNVLNEAGILTARKDLDYIGREELLEALKRQKGTFETGQEDSTEVPEELKLRLAYREAAVAVLACYLPDQYRPISETDINSIRSQPNMRYSETSGRVFARKSDYVNSIIRACAPRVVEEEMFGIENLCWISAKSTLEASQRAEFLILQTGMTAFGKAYYRNQRDLVPNLVPKLEALRDEYMRFAVEKCSSILQEYQSALEEITDVLLEKGEIKADEIWNIYNTAPRIPQKPVRPVDEYGALIYAGRWGIHGVSLPGRVTFSPGNIGFATFGAPRPMETQIISDDTWKLVDEIWDKKVEEIKAEAVIQIEEEKKKPQILMATHFF
The following text describes a protein:
Function:
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage (By similarity). Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity). Interacts with the structure-specific MEI-9-ERCC1 endonuclease to generate meiotic crossovers.
Subcellular Localization:
Nucleus.
Sequence:
MDRKTRRANFKNLQPRLTRSTKAAADTLSLSNFFATPENAEEVPSCLADIPVQPDPPAPKIKPIRTSNVFEKPGPKPKKAPKLKASTVSTSSGARRGRGKSKQQPSISNFLRNEQIFAEVTAQHCMADNFSADDIEMALALSKSESEKHGRLRLHDDDDAVVDLLDDEEKSTERIRHKLQKYGFRTAAKEDYKSLAVLPVVASKGGRRGKWANRFTSLTLRNPDVQQKKLEEKVSALLGQEMRGKEPNGEDCCLTPYTVITAALKELRAEGESRILREPSEGPIDDLESYYVTDLFEVSRTPAHHLLKNWAAIQGRDFSPERETQKCRQLRQQHELVYAELERYYGDPQKLEEEVMQELDELEKLVADNMIEDDSVVINIVEAESSSTGSSPSKEPPDKRPKMTMEDKENLQPTTSKASLTVPAQSTRCTSPDLFADSEDEPDIVTTAISNEPEDVRNLSMKVYKNVSISERSSSVAEIEIVSSNDEPSQITTYEVFSSDEVKTVSNATQEKISFDDDFIDLTQEFDMVEFNESKPRTPNLIASSETDSNVDNLNGDTILDFSSQEVSCPISKELYAKYAKVETFPVWNAAAEEEDKIEFSLSMERDLKSSEQSSHQLGILTTPNDTEHSSSFSELNFSRNSLRRSVSLSTDLSFKSPLNWKMNSSAEKRVSPAASPYKQSDASVDLTQNSDDENDAILLSDEEINYSIWKGNKTVKDLDIGDDSSDSCFASPVTKKRAIPQFQTEEDLDAFLMDFSTDGNGSQGSHSPNKSALSKERAEFGILDAAPSQPFSLSELQSHADKEKSSDNEINWAEASFLDAPAKPLSRRSSHKFNELLAKISKPAHNSGDDFDEFDQMVFQSTKEAASSAGETSDMPQGLDLLLKGEIKTTAIPETRAPGNQTPIEPQQVDVDGNVYSVRVCHTPKPDFATLPESEILQQLYKYGIKPLKRKQAVKMLEFIYNQTHPIMKTAAVQDLPARSEPIVRSKSTPVIMERPHSQVAKSTSKTLKAIGTKKDLTFNDATGEELLRFSQSLAPSLCDDFETFVMQTNVTKKTPQPLVPLHIAWHNLICANPQLHESVLTYEPIDLQAVYLHLKHMGHRYDPKDLKTFFDRRCIIFRYELGAPGKQAERHVRRHTKKPSKRK
The following text describes a protein:
Function:
Secreted collagen that forms part of the nematode cuticle, which functions as an exoskeleton and a barrier to protect the worm from its environment. Secretion and subsequent incorporation into the cuticle is likely mediated by bli-4, which probably cleaves at the N-terminal consensus furin cleavage site.
Subcellular Localization:
Secreted. Secreted, extracellular space.
Sequence:
METDGRLKAYKFVAYAAVGFSIAAVASVLLTLPMVYSYVSHVRQQMHHEINFCKGSAKDIFAEVNYMKANAGPVPPRNRTTRQAYGGPEVNPAPNLQCEGCCLPGPPGPAGAPGKPGKPGRPGAPGTPGTPGKPPVAPCEPTTPPPCKPCPQGPPGPPGPPGAPGDPGEAGTPGRPGTDAAPGSPGPRGPPGPAGEAGAPGPAGEPGTPAISEPLTPGAPGEPGDSGPPGPPGPPGAPGNDGPPGPPGPKGAPGPDGPPGVDGQSGPPGPPGPAGTPGEKGICPKYCALDGGVFFEDGTRR
The following text describes a protein:
Function:
May play a role in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MARNEEKAKSMLNRYLQLKGTESKQEERRPYLSNECDSLVDAEKWRRQILKEITRGITEIQNSALDEYKIRDLNDHINKLVREKGHWERRILQLGGPNHRALAPKLFDADGKEPLGTGTYRYYGEAKNLPGVAELFEKPEQTLHGTEKKTRQDLYKYIDSDYYGYRDDEDGKLEEIEREYEKYAIEQNVENWKKQQRDKFQINTNRFNNNNIKNSIAINKNTENKDEINIDDDEENDDNNNNNNNNNTENTENIENIQEEEEKEDIKFKSYVSLPSTSQIETILLEKRKEELRKRYTQN
The following text describes a protein:
Function:
Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (Probable). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells. In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (By similarity). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (By similarity). Down-regulates the activity of transcription factors induced by zinc and cytokines (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localization to the plasma membrane is regulated by cellular zinc status. Recruitment to the plasma membrane from an internal pool is stimulated by zinc while in absence of zinc the plasma membrane pool is endocytosed and degraded (By similarity). Localizes to the basolateral surface of enterocytes (By similarity). Localizes to zinc-containing intracellular vesicles in macrophages (By similarity). Localizes in the cytoplasm and to the ER, Golgi and nucleus membranes in keratinocytes (By similarity).
Sequence:
MGCWGRNRGRLLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAVERFIEPHEMQQPLVVLSVGVAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKGARKAGRAGVEAGAPPGRAPDQEETNTLVANTSNSNGLKADQAEPEKLRSDDPVDVQVNGNLIQESDNLEAEDNRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFNWKGCTEDDFCTNPCFPDPCKSSVEIINSTQAPMRDAGPCWVLYLDPTLCIIMVCILLYTTYPLLKESALILLQTVPKQIDIKHLVKELRDVDGVEEVHELHVWQLAGSRIIATAHIKCEDPASYMQVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVLPCELACRTQCALKQCCGTRPQVHSGKDAEKAPTVSISCLELSENLEKKARRTKAEGSLPAVVIEIKNVPNKQPESSL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Sequence:
MGKRQFTSQASSTRAATITAPGSGFGFTTTSTRLSYLSEPSNLSLISDANVVVSFKNLSKKDGTTKSKGLEDLRTFVQNQPNEQGGIEEAILEAWVNVYPRISIDNSRRVRELSHSVQYELLKSARKRMERYIPKIVGSWLAGTYDRDRTVARSATDGLASFLDTDAKMNMFWKRCQNEILDYAEEALNETPYTLSDERSVPTEDANEKYFRVNSASVSLLANLLAKLSNDDISKHQDIYEKVIFSNKKLWTLASCEDASARKSTDKLLLLCIEKQTQLVENNLGTISRAFISKALRSPQPTSALQLLQTLYQLTKQFPQVWTSAYKGKHSATDDLKSFVRKGSQGSSPVYWQTLRALVAILPIAVLPQESGSILEFLEVFRKSINQREEHKSNSHDAWLAYGQTSNICIGNLSSSEQMEVTQKSTYPVFEHYLHPSSNTSEWLIRSNTPSTTVSFFIITLGKNSNLQPSFGEEWQKLAQGFITRIQTSMPEQSKDYSSSQDAVIAEGRRWFSLLSETFKLKDLAADQNPLLQPSRDIVESALQVIINRNGKPYSASAVLEFVLRSSPQLFEASSSTLEAVKTFMETHLPKLLSSPSSSYLASALDQFRSIPGQQSRYKNIWQAAIDALLSTPEDLQRQKTITALISCNDVSDLVIDNQALQGFLLETSCEVVKGNNEGWPLFEAAVVFNGFSKPTERLLLQSMISALDASNPRINLVFKALELLSIRRPEVIREGNAHVDLITKLLALTELSDSELGKRAISLRSLIDNGTGVTASSVVHIIKENLENANPQTLTIDTLIQQAEAVIATSDDNLLHLELFPDAIKWSQALAPLLDQVPNPTLGVMRPFAGAVFLVRTQKGSDISRPERDLDGYSVALRMAMYSARLIREHPDRLSKDALAEILYLLGLTVELANDQLDLLETNKLFVLSSEEAIAGAREFVDRIYQESWSFILLHSKAWQEGFESGSPLEFSGVVHTLVLKLLNASSGNTSTSFYSARVLSHLLPKLVEQHGWPAGSEEWIVNLEILKSSTSNVLGAVAILTGLHETLSTSQIVGNLCNRLISDVAGATAQSEKSLGLLVLLNATLSIYDGDDLPVAQNRLVFAVKQILSWTPEIASTNYQLSSESCLALQRLLPAIKSVYGSYWDKTLEFCIKTWESMESEEHYDQKLPMTGMSLKLFSSLRSLQDANDDLEDALTKYGETASRCFIKLMKLPRFKPTQPIEIVQSAAFDVLHRAIPAEQEEISVNAILEKKDAQLPVELLSLLLDAPSIRNFDDEELAEFPPSIRSYLLSWHLVYDSFSTASWKVRKDYCNHLQSENCIGSFLTFLFDVLGHSGGVPLNLEKAHFNESYIRKYDTSLADAEPNERNMQWLLIHLYHLCLKHTGDLAKNWFSDCQSKQTRQAVETWTEKYFTPLLISDKLDEVDEWAVSKEAKEGGEKELEIKASKGVRSVFAGYEIDDTSVQIAIRFPPNYPFYNVKVEGLNRVAVPEKKWRSWLLIVQGAITFSNGSLIDGLTTFRRNVEGSLKGHTECAICYSIISSDKKTPDKKCGTFLGEAFHEGRDEGKLWKELLGFVGGGESWLI
The following text describes a protein:
Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Sequence:
MVSHSCLTDLPRRRRSITEETQDVSCAALPMNPLQYQCTDVSRRQCRRRRQRKSNARITKSNTSATMLSSAAVTAMLLLAPLPSTATASKSNLRSPNKQQQHHRNTASYPFLPSWTSETCTSTRPAESWETSHPSLEACCAGHFAWKTDACVAAGKLKLNSDNDGSSNSYPYLPDWGLGSCTNARPAKSWETGSSMLKICCEANFHNTVDDCVALGGGTLQDDASLFSSTTVAPPTNNLQFAPPAVIWWFPQWQSTSCTIDDDDTPAPEYMQNDPENQMSPTFKACCETHFKVSGEVQTCLDNSIVNAVPTRPPAVDNDMSTIPVDLSVYYYPKYTKNKCVVNGMTAPEYMQSDPIVYMSKSASECCEVQFPLNVEQCWKRSGVVVVNDSGSGGTNDGGTDTSNNDAMFNAARYQDHYYPNFQTMGCVNENDAPSYMKEDPGAFFFTTIELCCRSENYELDYQTCVENSVDSNGGESGENADDDMGQNSSQVETYVPQLVIGFSGRMYFQNVFIPSSNQANMVVVRDAIIRAVKSSLSRGYNVMKIETKYFDGVNLIGIRRRRLSGESLEEESEFGFHPRELARMQMFSFDLTISTDCSRACAQDVSTSGREASFTIGEYFEDSIKDGTVYHALKSDMESQGLIGPFYSASLNDGNLMYESAVLDMLTYTFEPTPLESSKPSVEPSSSPTRSPSASPSDPPTKWKSSNPTNSPTSAPTPGFKFYPDYSLGTCKADGKHSEFEFNFFDSLEECCNFPWLVKENCLQLGGRYTKMPTMLPTSKPSMAPSRSPTKSPSSSPSQHPTRKQVSAPVTQAPVTGNPTPSPSREPVGGCTNLYHMDTEGNVDTCTNSLTYPSAWDNVQVVHMHLFATAQACCDAKFSTASDCHVVNVCEDDTTTENSSPTGTTSTAAHPSPTATCGNLGYHVNLEKDGSCTDDNNIVTEWLPQMYFTTGEACCDKFIPGECNIVKTCSSDAATTVSATPPPVSSPSGGTPACDAKFHISIVNGAQGTGLDCSVVNVCGKQQEEASAGCAVGWHPSLDEEFTCTNSDNFIAMWPPTMFFDTGEGCCDEFFNGPCNIVADCSSPIEVATTTTTKPTTVVISQALLLDWESETIDDNLVKFEGIGKWSIDDSQPCCRDGVAIHSPRLIPGEYSTMVIEYSAPSGGSRLSFDHNVGLGTFTFFIDGKEKLKVAVPGGGTNTFMGDLEPGDHKLSWRFDAPVMANLPFETTLADQVAACALHHYHHVLPNNNGGKPQAGKEWTVYAAVIACQGRRSTDVGDGAHHVNSVDDNDDLWVVSCATGSKCTSVNSVVSSLPTPVSTTVISVDTTPSSKGTFKRNVSREEETKICQLYNGMILKDSHAEVLARRGLMAALWKEIEHTLTQSIKEQSKNNGAPSPTSKHLLEVATPLSTPQFRLKSGITLHMYISDSPCGDASIYEIKTMKMQESNQSEGSTKYFGNNITTDGFEPGLNFTGAKIIMSANTSTKSISSVLTFTPATSQSIAIQLGREDIQQLGALRLKSSRSNIPPNQRSSSMCCSDKLLVALERALPTRVENTLKSSLEASLSVGPPTVAVIDQTFDNSKSASEHRYMISQVDNRIPYGGIVKVSTQQLGSNKRRKMNHDTEKTDCSCNVRKESACGMSLNWHQSQTSTKANMPEITIGASGLKRGKKPKKPRDALNCASRLCRLSFFQCWMKCVKMSSNCSVPNGDSKGDRSYKQCKDSVDDNAAVCVDSILGGGVREEYNTGPLRGWVRSGIDGDFAISLD