lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a transcriptional regulator. Binds DNA and RNA (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAGFGAAPDFNEGSKINASKNQQDEGKMFIGGLSWDTSKKDLTEYLSRFGEVLDCTIKTDPVTGRSRGFGFVLFKDAVSVDKVLETNEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPETTEEQIKQYFGGFGEIENIELPIDTKTNERRGFCFVTYTGEEPVKKLLESRFHQIGTGKCEIKAAQPKEVYRQQQQKQQRGGRGAVTGRGGTRGRGRGQGWNQGYNNYYDQNYGGYGNNGSYGDQDYNSYSGYDYSGYSYGYNPGYTEYSGQQSTYGKARGGGNHQNNYQPY
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MESGSDLQSYWDDESEGYLSDDDEREDETASQQSEDTDFFDEPESNYTIISEEEICQRQGDAVSTITNFLSVSETEAGILLRSLKWSVSTINDTWFADEELVRRSVGLPTPPPESRTLASRDLVAATDPARRAKCPICLDMHAVSTMTAAPICGHFFCDTCWTGYIHNAIRDGPGCLTLRCADPFCGVAVGEDMILSFAGDEDQGKYQRYLLRSYVENNRKAKWCPAPGCDYAVEYSHSPAPGSHDVVCKCSHRFCWNCLEEAHRPVECETVAKWIVKISSEQLVQEEEAPVMSWDPCSRCNWPDNIDWILAHQKPCPACRRFESWMLGNLKPCPKCKRMIEKNQGCMHMTCTPPCYFEFCWLCLGPWRNHGDSTGGFYSCNRFEVSPSLALAPAPTPTPSPGVVRVQQMESARNESGKDLKSSPRERYRFYYERWAAHEVSRLRSSSDIQRVLPVQIEELSDLQFQPTSQLEFVREAWLQIVECRRILKWTYAYGFYLPDDGGPKRQYFNYLQGDAEASLERLHQCAEFELHHILRVRGDQTHFDGFRTKLQSLTSVTRTQFKEIVLVLENGLEDFADRSLPK
The following text describes a protein:
Function:
Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the presence of deoxycholate inhibits cell growth completely. Bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum.
Subcellular Localization:
Periplasm.
Sequence:
MYTRNLLWLVSLVSAAPLYAADVPANTPLAPQQVFRYNNHSDPGTLDPQKVEENTAAQIVLDLFEGLVWMDGEGQVQPAQAERWEILDGGKRYIFHLRSGLQWSDGQPLTAEDFVLGWQRAVDPKTASPFAGYLAQAHINNAAAIVAGKADVTSLGVKATDDRTLEVTLEQPVPWFTTMLAWPTLFPVPHHVIAKHGDSWSKPENMVYNGAFVLDQWVVNEKITARKNPKYRDAQHTVLQQVEYLALDNSVTGYNRYRAGEVDLTWVPAQQIPAIEKSLPGELRIIPRLNSEYYNFNLEKPPFNDVRVRRALYLTVDRQLIAQKVLGLRTPATTLTPPEVKGFSATTFDELQKPMSERVAMAKALLKQAGYDASHPLRFELFYNKYDLHEKTAIALSSEWKKWLGAQVTLRTMEWKTYLDARRAGDFMLSRQSWDATYNDASSFLNTLKSDSEENVGHWKNAQYDALLNQATQITDATKRNALYQQAEVIINQQAPLIPIYYQPLIKLLKPYVGGFPLHNPQDYVYSKELYIKAH
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPMNFKVTFANGTSIRLMGLSDDITLDGLRAQLFEKTSIPPQDQHGKSSESTLSSLGVRTGSVLVLKESPDAGGAQTQKSTLVFMRRVVPADNSCLFHSIGYALGKGREGNGPMMRQLIKETILADPEKYSEVFLGRPVYEYCAWIMDDKSWGGEIELSILSTYYKVEMVVFDVTSMSRLCYGEDQGFTQRMFLLYDGIHYDLVVETPSTTASERQDVTLFAINDFTKVERASEVAVEAHQKHEFTDREALSHSEATGHQQFGEVKPSSSR
The following text describes a protein:
Function:
Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL
The following text describes a protein:
Function:
Involved in the regulation of cellular expansion and differentiation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRGLPNFYHSYTFFFFFLLILFPAYSISANTLSASESLTISSNNTIVSPGNVFELGFFKPGLDSRWYLGIWYKAISKRTYVWVANRDTPLSSSIGTLKISDSNLVVLDQSDTPVWSTNLTGGDVRSPLVAELLDNGNFVLRDSKNSAPDGVLWQSFDFPTDTLLPEMKLGWDAKTGFNRFIRSWKSPDDPSSGDFSFKLETEGFPEIFLWNRESRMYRSGPWNGIRFSGVPEMQPFEYMVFNFTTSKEEVTYSFRITKSDVYSRLSISSSGLLQRFTWIETAQNWNQFWYAPKDQCDEYKECGVYGYCDSNTSPVCNCIKGFKPRNPQVWGLRDGSDGCVRKTLLSCGGGDGFVRLKKMKLPDTTTASVDRGIGVKECEQKCLRDCNCTAFANTDIRGSGSGCVTWTGELFDIRNYAKGGQDLYVRLAATDLEDKRNRSAKIIGSSIGVSVLLLLSFIIFFLWKRKQKRSILIETPIVDHQLRSRDLLMNEVVISSRRHISRENNTDDLELPLMEFEEVAMATNNFSNANKLGQGGFGIVYKGKLLDGQEMAVKRLSKTSVQGTDEFKNEVKLIARLQHINLVRLLACCVDAGEKMLIYEYLENLSLDSHLFDKSRNSKLNWQMRFDIINGIARGLLYLHQDSRFRIIHRDLKASNILLDKYMTPKISDFGMARIFGRDETEANTRKVVGTYGYMSPEYAMDGIFSMKSDVFSFGVLLLEIISSKRNKGFYNSDRDLNLLGCVWRNWKEGKGLEIIDPIITDSSSTFRQHEILRCIQIGLLCVQERAEDRPTMSLVILMLGSESTTIPQPKAPGYCLERSLLDTDSSSSKQRDDESWTVNQITVSVLDAR
The following text describes a protein:
Function:
Krueppel is a gap class segmentation protein.
Subcellular Localization:
Nucleus.
Sequence:
MNIRPIFNTKEVLDQEITLCDMLMACAPITVIKNDGLPDRICDNCIEELRKAFSFRKMCENSDTTLRNCLNNLKPVIVQTSHEIEDIKPNISDDLVEESQIDWGDNSLSGDTSNEENLKDVENNTKTLENGRRKRSYKCKECNEECLGLASYWKHMSNQHGTKLKCEFCDKEFRTPYLLDEHKSSCPGEIEPKPKRTRKRTGITKKRNLPRTCDVCHKTFRFHSNLERHQLTHTGERPYLCNVCGKGFGQLSYLKIHSFIHTGEKPYKCQMCDKSFAAPGTLMTHIRIHTGERPHVCKICGKDFPQSGYLSAHIRTHTGEKPVECHVCHRRFNQSGRLVIHMRIHSGEKPFSCNECGRSFAVKGTLKKHIRTHTGERPYVCSVCGQAFAQSGTLATHMKVHRPKP
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes; Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MAAPKVKQDMPPPGGYGPIDYKRHLPRRGLSGYSLFALGIGSLLLGYYTIIKWNRERRRLLIEDLEARIALMPLLQAEADRRSVSPCSTPTAGCPRRWMSSTTSAHLLRWTTRSSGCSTMCDWQPRGAAGSSALKLCRYPATSVCSAPFSLLGILTGLSLPGSIVRLQQCRVGWDWGAAHIFTAGARGGGGVGSRRRAVRGCCCPECPPWGLSALCGHGGNGSLGVAVVGVWRSQGVQGVGLKSRWVLLLGRGKALCPWRARAPLALPRCPQGFSAALPAAPPAGDRGSGG
The following text describes a protein:
Function:
May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
Sequence:
MAERVLANLEAKFTEGNYYDILQSYKALYNRFSTQKKYKETVTLLESGCNKFLEYKQWNCAADLAKLLIECYKNFKIQYSDESKEPIIKIFKNFKGECAGKISFMRDAIEWSSKNGGDSKGSEEFHTLLAITLSEEGDYIDAQKHFIFGNDYFSFCEMLKNWTEDVDEEEKDLYITRAIFGLLCLKKLKQASDLYNLFTTKVIKGDPSPLLNFDRFLLLTLERDALPLFNLLRQKYERSLKRDPQFKKFLDQIANIFYNVPIQSGGGLSGMLSNLLSGFGGGMGMGGNSSGGGLASMEVDGPTIEDEMD
The following text describes a protein:
Function:
Probably a thiamine-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSNSKFNVRLLTEIAFMAALAFIISLIPNTVYGWIIVEIACIPILLLSLRRGLTAGLVGGLIWGILSMITGHAYILSLSQAFLEYLVAPVSLGIAGLFRQKTAPLKLAPVLLGTFVAVLLKYFFHFIAGIIFWSQYAWKGWGAVAYSLAVNGISGILTAIAAFVILIIFVKKFPKLFIHSNY
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQLVPFFFVNQVVFAFIVLTVLIYAFSKYILPRLLRTYISRIYINKL
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MNKQSNTRDLVWNGSLSISVTTESSPLCYMTNIPRLSYIAFILDEVRKILCPNEKLDNCWLEFEGVPLKSHWPIGVLYDLYTATDPDAPRSPVLWKLVLHYDNFPASQLIPCNEPTTFRTLFFNALKESDYVRNKSASYILSLSNSATEELWTSIQKHDFEVYQRFIPRLRSAKYDQLPVRIYITPDTPVVQESVSCKETLGSMLHKTLPKLFPSQNIAVLAKAIVHGISIPLSTNMNLLNQELCYTDGFVHIVIHML
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MAARPDDRPVPATRRSVPSATIANGSVSSGPISSGLLINVIRTLTTSVNEDQRELEKKKLEKGYKESGDMIERLIKEHQGDIENCLSTFKDVSSRISVCRERVINVRNALGQCKQILENKRDDLKKLWVESSEQRHVVEIMNKLDDLRNIPIEVEILMDKGAFETAAETITRAKVEMREVECIEGLGGVRTRLEELRDDLTTRIMMRIVTAVVDEPFEKNMAEMLSGIPEERIASTTELSGLAARLKGRVSEDPLVIRINRDVGALEVLDKELRVLERLNHMSAASIEKMIRATISLVRVRNNTDETHPPDHKALAQMIKVIFRQLEASRDAHASLAERTRQQEVLKAFWRHAQTSVDSVVSEHTGLSSSGLKSTMDQASRLFRFEGTAYASFVSSSTNNRVICRPDVYNIVPLYPWLKHLISTIEESSGVKPCTLSSFVELVVMKNFITRLNDDFTHRLDTIVRGARSAEALFDGSQKAYEMCSEGSCSEVQHLLVSMEQYAPQLAALWLIVITQYTTHVRMIYERSTVHFLDVNGVTVQQKKISAAWAADEDISRLLMSLPNWQLAHASDAVVSPMTGVHSEKVIVSIETAELMTNMEDVRRLAIVHESLRWLAVKIRGLLESIPRQIKTTLQAVRHSYERSDGTREEGASLSLIDRHVAGVEANSATCLLMLHLELRVHCFYHLLPLARPRGGGGGGGGSGDDVDQEVHDLGRDMAAFYKLLAEILAQPKLNYIFDGLGHLCAAIFIHSSQHMPRLTDAGKKRVCRNIWGVQQRLSQLTGRREAQLERARGFYELLSSDVDRIIALVPETSKQYSNVELGHLVGLAVRSHPLLSTQPGALEAYLQQLRAAIKAAR
The following text describes a protein:
Function:
Involved in endocytosis.
Sequence:
MSRKKLDIESSVEKARNERDWHQLASIADSIREESIFKKLITIEGELEILITANSIPSDKRNEALSRLKRQLMSIGNDTKIKQQYQQESLLLLAKTCYYLNLFKDATRLYSKLQLESIDISDNSNKWFIRTVCEAYCYKGKCLDKLRSTSADIIKCYESASSLMMKLDVSNNFNKERRDSTSKFVVGEFLEECIGTMPSLLLDKCSTSDVIRRSRFLLVAFDSNLFLRLRALLSYHLAEILLFRMSDHKYLPVTLKSIMDFANQKYSWVKPSLNGKNLYFPDDITEEVLLLSLITEMLTIKDIENIGFSNLNRLRNIYDLLAVVLMRRSLIPIVAEVYERALKYSMDIFHVWFQFSLSLIANRKVDDAEFYASKVIDQKESRHLLANAHLILGITYSRQASSVLLINHRKKLQERALNSLEKAYELAPGDYRTSFHLALNYAFIRDIVNAVHYNRIALQLNRTDLRCLHLAALLLSAQKKGRQALDICDIAATEYPDNFSLMFLKAKLEEVYISGNQALDTYKTILVKYHLLSKKARLHENKARSDIVSTASYNQLAYSDDASSLSGISTTGSKGLSSYLDFELTPRLLTKIWLSIADIYIQLGRLSDAEMSIKEASMISSKSVDVMHYYGRLLESKGNLREAKQYYDNVLAGNHDHFNTLLHLGFTHHELGNLDMAEKFFLEAIKVEPAAHCAWNALGAILQERNCNDTAAEVFLLASDFESTSPVSSFYSIAQFI
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSAFAARQKLLAAAASAAATTPNMDDNDNDGDIIDRNTSAKSFFTRDNFRKALQAQKQEPSHHVDDTPAARPRKRKQGPKDQVPAEGRDEGRQLKSQFPNLSEPMPTGRRRIIYYSSQRLSQTNIQPKANGRMLLKLLDGERLVILGSYGIKVREGELTVAGAFLSKSDLVHWVHAPQCHALPVIRITNDATIELHPHPGAQSLRQLASLNPAFGKLWNESDDVAPGQAKKVFPTFQIIFTSDDAPKRGGIQELVSPAEWNKQLADVLDSKRKATPVVFLTGPKSSGKSTFGRLMANRLITGSGLSRQPWAPVVVLDLDPGQPEFGPPSVISLNKLSSPNLSPPFCHPALDPRTAQLRAHTVASVTPSLDPDHFVACALDLFHTCKTNPSLNKLPLIINTPGWIQGTGLDILSELIRQTVPTEVIYMSQDGPEETVDGLKAACQEKKIPFVALPSQQPQGQPSSSVDATTPATSGGGGSSRTALHLRTMQTMSYFHLLFSSLTVPVPHSQSQNQSQPHPGPTWSATPLTHLPPWRVRYRGPRPGFLGILCYDHQPAPDLLAEAINGMILALVKIEDRAGAFRDFPDLLVVSSPQKQQQQHQQSIQQFKKQSSSQKQQQPELLICKTPRESLPHLPNPQGKTLSPAHSRVLGLVLVRGIDVRRGELHLLTPLPVEMLAGNEQNLVLVAGRFDTPSWAYAEDLHRRQWEKNNAAAARNKQQGLVLGGSAKMEIDDDDDDGTGDGDQSDETESVGADEVEERPERERVQALHGGTSEAQPWVEMLHGSQGRAAGSKVWRVRRDLGRR
The following text describes a protein:
Function:
Mitochondrial RNA-binding protein required for the stability of the atp9 mRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MRILGSLPNNIRKCTFKLILQKRYSHTDILKELLYDISDSQKFIPSASPIASNLLRVSSYGKLSSLFIEYSKARSKKEFDQLRTSDFQSILRSVVCPKNGKNIRHRDRDLVSLQIKLILQDADRLGIQFNIVDYTHILRVAMYTGNKHILEYIVARVKEKRIRPSVDYFNAILGVIGGNRWSLSKFQSPAFRGSPVTEPVSGKMLDMIEVDFPNYDLVPNSTTYDYLMVGLSRDGKIREIYDLIDTVWGINENSSSKKVDCGNVTFPTHHTVFSIISALGYLGDVSSAVSLSRKLTSVYKINFPELAWRYIIYWSIASLQFRAPAGHARIKNIELFIRLYSQMYRHCVPIIEIYDTSIKFYMKHGRFGLLEKVCESWTKQFLGSLEKQNNEVKKKHLQLLEKQISKLMRYAETERPHDTKRVSVKWSNVLNQIHSSVGDPAKP
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAGPKPKKAKDAGKGTSLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY
The following text describes a protein:
Function:
Plays an essential role in viral DNA replication. May participate in the DNA replication initiation by interacting with the origin of lytic replication, oriLyt and subsequently recruiting other viral/cellular factors. Additionally, interacts with and shuttles IRS1 viral mRNA from the host nucleus to the cytoplasm (By similarity).
Subcellular Localization:
Host nucleus. Host cytoplasm. Note=Shuttles between host nucleus and cytoplasm. In the nucleus, colocalizes with UL44 and IE2 in the viral DNA replication compartments (By similarity).
Sequence:
MPRVDPNLRNRARRPRARRGGGGGVGSNSSRHSGKCRRQRRALSTPPLTFLATTTTTTMMGVASTDDDSLLLKTPDELDKHSGSPQTILTLTDKHDIRQPRVHRGTYHLIQLHLDLRPEELRDPFQILLSTPLQLGEANGESQTAPATSQEEETAASHEPEKKKEKEEKKEEEDEDDRNDDRERGILCVVSNEDSDVRPAFSLFPARPGCHILRSVIDQQLTRMAIVRLSLNLFALRIITPLLKRLPLRRKAAHHTALHDCLALHLPELTFEPTLDINNVTENAASVADTAESTDADLTPTLTVRVRHALCWHRVEGGISGPRGLTSRISARLSETTAKTLGPSVFGRLELDPNESPPDLTLSSLTLYQDGILRFNVTCDRTEAPADPVAFRLRLRRETVRRPFFSDAPLPYFVPPRSGAADEGLEVRVPYELTLKNSHTLRIYRRFYGPYLGVFVPHNRQGLKMPVTVWLPRSWLELTVLVSDENGATFPRDALLGRLYFISSKHTLNRGCLSAMTHQVKSTLHSRSTSHSPSQQQLSVLGASIALEDLLPMRLASPETEPQDCKLTENTTEKTSPVTLAMVCGDL
The following text describes a protein:
Function:
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
Subcellular Localization:
Nucleus.
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MSSLPTPLPPYKWTLLTAGNANVVYKSDETDLLLRLRRNRNAPSTAEVDEYLTGTIRPAIGPFLFHYTVVNLPLGFLESLPEAENLDLGEPLGLLMENLGPKPNETNVLKSHAVKINYSDNWESYTVELKPKWLLQSPTAPKDSINCRTCALQLKREKPRICPLKLFNEDEQTSLQALEDVFPGTQKQFEPLAKFFSNSELFAEIRHMQHGDELGILGYANYVQVPPQFVTAMTMRDVSLFVHVQGDSVNGKIVDADLKSVSEKRDYWASLETDLIEGGWYEKPGTNCLLRN
The following text describes a protein:
Function:
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Sequence:
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGEFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDMLLQPWLETRIWPLESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKDDEKKAIEEAEKYVKRYYNESDMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIAHGVVLNDDERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALSLATKGAAEVIGMKQTGSLEAGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKHVVWNGECKTLDEERIIFEASRYKRGLQR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MGMAAPAGVPTGPPEPPPQKHEPVPLAQLVQRTTSEAYTGIQDLCKSLPGRGEKERKLALLKYLVRTRQRLLRLHVLAEWAKTQAPLMSRGQQLSGTLEWHDTSLRDAADQLFFLHAQLRQARAPIYDVTTAVEVLTTGSYSRLPIVIQDLRPPPTLVPSEQASALSKADRAIHARLLECELPPQLTDIRVSDGAVRMRVKDEFEVRLTLGHEGDLSKWRVLWLALGSEAEGRVTKDGSEDQGFGEKTRGVRGGGSRGLTEGQRRALAAEVERRMGLAAEPLHEMYRVLHELAANLLLDSVFRQAQVLKQGTWRDVIRLHFEKGDAGSVHRSLKIEYWDRRSPGGVNTLQSGSASVEPFRPSPSSHLTPQLDQPLRGETPVSGGKNWALKGPPSLRIELDDEGHVACSHWPVVVDPESEESALFSVAQHGGSLEELLRKALACSAHSRLLELEEIVNKEPLVRCKRSFREGGVAFGSLDEGRAEEEENQEGAEKLWVQVYGSVGAGVEVNRRSGRFVLRQPVGLVPDSLLRQLEERLNSGGDAPGSLFLELRKAALLRLFRSMAVEMELEPYAHGVAALDTPEDGPSLPPDTLLCSFPGVLEGFSFFLAISFDDFCIPFFTLLASDERDDDSASDRSEPGVSGPISGLVKGPVSGALSGALSAAVSGGVSASLTDRIAGAVGAGSGMGLAAVSRAVRRSFAVRPQVTKWMELGVGEKVIDDGDSEALLLGWGSESERAAMVEEEEKLRKRVELERAEAETQVQTGLTSVSLGAGWKEQSTGSLLGAKSKERSEDPLGLLKEWPDSVDLDTDWTEAPEALGGSGAPPLSTTLGGSVPHEEKPPESAGASTEAASGANASGVNTASVSAPTVKASGGPRFERSLTMDMVEGLLDMLGDEEEETKTETANLTGVSDNLPGASADLAEGAEGLEVWEGTTGGEETEAVGNGDGGTESVAEGGLKRPRESSMDIDIEAAFRGFGGTDESNGLAGQEGRAEGNDNGSEEPSAKRQKVGPEPSQATGLEAGQALTGVQMNGETAPEASDEKMEEAGSLAEASLDAAGALEDSILDFDPATAPKAEPLEGDAEIDTEMHASPRHPTTVDHVPEALAHVSESPKVEDRCRLAVGRRFSSLLAAANQGRAPPEVYRAALYRALAHCSLCIKHDVITRQLTSAGVAYAEEVGLRRPSFDLRAKVPGLDGGDDVAPSWPPVKVLLGGPGVPGVTIRVEDGYLGALAGLERRSKAGSALRDGSGVEDASIDEEKQNKVDEVTEGGAREGDKETADAPPNRDWLSRGDIHFLESAPEDAHIQSDAKGFEIRVKRITPSFATDLVRDLKRVWLARAFVLHLAEALGVLSGVHAGSDELEVLAGKRGVSDSWGEVTITGVGLTDVEVRFENFRTILMSVTWPRTSGGAKVSLLPQALETLEHQLEEFVNEGEVALLLDAVSVTAVPQGLLAESLPCTKLMRRAMYSPTEVELKLWSPYRARFTFRNCFTLEMRCFAGAHVWLQPVPPADPSSSRGYAQIPGFQWCVNEELAAARTCLEGGTTPDKGGPPERGGAGDKGTAAGGQGSGETEVGESLGVSEPPPEKLARFRSFGRASGSGGLQSFPSFGRQGSSGRGDSETLISPGSVSSGALKLPPPGSTFPGGRPRLTDTGGYAGMWVPWYAIPQVCRGLWPNLAVHWAVITFVECVQTTRELLTRDNEWQVLKHDASRPLLQLRCGSLAVQLSASSSSIRFKLQSGTQQESPITKVDAADLDEYFHARVLRSPHHRDRIASFVTLLALPIKTLRDFVGLIRWEKVEIVVERDRESKGQGGSNVVGEICLEKKPLPPGGSEFMAPFARGDPPVRERDPSGENAEESLRHVEGNVYYNRRKGVVDFALGFVCPVSHNRALWRQETAPGDWGGGLVGPERRFLLTWLRCSVQDESIQLLDVQGPLEPTAKERLTMLITTALDLNTRGESEGSKMQRAATAIQATLVSQ
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs.
Sequence:
MLEILYQDGFLVAVNKPAGMLVHRSWLDPHETQFVMQTLRDQIGQHVFPIHRLDRPTSGVLLFALSSEIANLMCEQFEQKYVQKSYLAVVRGYLQGKERIDYPLKIQLDKIADKFSQEDKEPQEAITDYEGLKIVEMPYPAGRYQTARYSLVKLIPHTGRKHXLRXHMKHVFHPIXGDTQYGDLHQNRALMSHLGCSRLFLHSDSLSFIHPITKEQITITAGLDEQWQQLMNQFGWENV
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MVRVSDNELSDKELVDFLSEDSDNGDENLLNKKYSDKEALITLEVDFPKIVTILGIPKVESEKHGRLAEVLKKLFIRHLSAKISDSSLLNMKIHMPTDEENKTKGICFVTFNDSFQANEAVKILNKLKLDAKHILTTSKMDDIENIINRDEKAMPINVVGFTREKIRWWLYDEKCREQFIVRYDSHFEVHWFDPLEKEPQLIYTTFKKNAPFSSVQWSNQGSYLVSFHNPGIALWGGDSFEKLIRLQHKSVKEIMFSPNENYVLTWDGTPYSLRNEKSICIWRVITGKLLRSFITPEYSPKEKMFPHFLWSPDDKYIACIGKQKEVYVYELPSMLLIEDQEKKRTPLKYSGVKEFDWSPVDNILAIWIPQTNDTPGTLILVDVPSRKELVSRKIYDVSVASIHWHNKGDYLCLKTTIQKKSGKKIKKEYTQLEIFRMREKNIPVDNVQIEAVKTKQFHWEESNSNRFALILREETTNKQQIRFYKISNKGTARDAKWSSTFDINNQMNFMKWSPQGTYFILASLASEGTLYFCCLNNNDEVDVIHKDEHLLVNSISWSRCGRFLVSAVSNNPNAFNTGYREENSEAGFHIWTFQGKCLMRIKKPSFIQFLFRPHPKSLFNDKLKLDIKNNLNNYSKKFDNIDEKMKTAKKNALLTERKNVENSFNQKFQEITALFQSYQEYEQLKKNWETFENQFEWEEKTIVIEHVLSVKEEIFA
The following text describes a protein:
Function:
May be involved in a late step of spore wall assembly.
Subcellular Localization:
Spore wall. Note=Predominantly at sites of spore-spore contact.
Sequence:
MRAPPSPRKSKSGHFFYLYFRLCQLFSGRKLKRRWHVHKLHIHQYNTRWNLSPLSEIHIEDMINEPSGLCPGSSKKKPLLIARFPKGCQESPRVYVLQRNNLSRLKLSKRKYALRFYHNEIFGNNLKRKDGSIHKVEHQQCAETVRKIKKVTANHADVKIIFHDKNTIRSDKLGGRSNKMQTRPSVLEEDVEEEVSSVYIRFCDDHSLRVKDYHSLHRHSKKSSKEKRNNQEIGKSKLLGKLFEEETSRQNKGVEKKLDTIVIQKFQNYPIVSFSRVI
The following text describes a protein:
Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
Sequence:
MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYARHIDSSPYSPAYLSPPPESSWRRTMPWGSFPAEKGQLFRLPSALNRTSSDSALHTSVMNPSPQDTYPSPAAPSVLPSRRGGCLDGETDSKVPAIEENLLDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPATVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGSSTSNLTHTMTHLGISGGLALGPGYDAPGLHSPLSHPSFQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLARHALPTTSLGHPSLSAPALSSSSSSSSASSPVLGAPAYPASAPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVALDTSKLPTDQRLPPYPYSPPSLVLPTQQPTPKPLQQPGLPSQACSVQPSGGQPPGRQLQYGTLYPPGPSGHGQQSYHRSMSDFSLGNLEQFNMENPSTSLALDPPGFSEGPGFLGGEGPVSGPQDPHALNHQNVTHCSRHGSGPNVILTGDASPGFSKEIAAALAGVPGFEVSAAGLGLGLGLEEELRMEPLGLEGLSMLSDPCALLPDPAVEDSFRSDRLQ
The following text describes a protein:
Function:
Could act as a modulator of transcription. Plays a role in spermatogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MNGDDTFAKRPRDDAKASEKRSKAFDDIATYFSKKEWKKMKYSEKISYVYMKRNYKAMTKLGFKVTLPPFMCNKQATDFQGNDFDNDHNRRIQVEHPQMTFGRLHRIIPKIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPGKANISEKINKRSGPKRGKHAWTHRLRERKQLVIYEEISDPEEDDE
The following text describes a protein:
Function:
Involved in post-transcriptional regulation of gene expression, probably by association with mkt1.
Subcellular Localization:
Cytoplasm. Note=Localizes at the barrier septum.
Sequence:
MATRSVSMKQTSQRAASPNKTQGAKKWSAVAARGSKIAQSATNDHRNVESIKVVPENRVRGGVAAKATDSSSNVTSLASSEENVSSVSGSAKSNNSQQRVWKTDVAISAEKRTETRQRELRRWMPDPEDAGVPLAGLEESTDNVEWDQFATNEKLFGVKSHFDEDLYTSRIDRSHPKYKEKEQEADRIAKEIEGTVTNNIHIAEERGLKVDDSGLDEEDLYSGVHRSIDVVRNYTRSNAYNKNNKDQKPKNHEAPHQHPQQKVVPPDDPAIVSHRHLALPRAPGPDSRAAERFFNARRKAGPLSRREKEGQIKEFMQFSQSLKIGSLDSKQPSSTKSVAEVKVADEKQLPDASSQATPADSKEPRKEEAEKPVTSATEVSSEKVEKVDGNTSSPSKEEEKPSTEPEKPSVVTQRKETTGTKLGTKLNAKAISFKPNVAAPVFTPGKFTIPSKPAPVNASRPMMPQQSNNSEASIPSTTPQSPSVVSNGENKPSSSPVFFNGPVSSEKEPILDNFNVFKNVGEEHQGAEQIDKPFSCPPTWNTGPNSLQQTIANSRPEGNSGSAKKAAAANPMIPSIVLPNSAMPSAMPMYPTPTMPYIPVGYPVPGYTPYMRNPSQHTSVAPSPNGTPTSGNSSTVGSPMIGYMAPQFIPPYAMPQFPPSGNGRGASAPATYFVPQMGGMMAYTMNGVPPMYGQYAPNNGMMNMHYPMYGDSRRSNSQRSFNSSNGKRSNVHKNNNASNTFSHSNASTSSSLNAAPNTTAKSSSQTAPPVSKGDATEKTEKDASANQEAKP