lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Guanyl-nucleotide exchange factor that regulates small GTPases (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms (By similarity).
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MSDQQKASLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIERPSSAAGSAGAGNDRPGNGGPGGHGGGAGGGAGGGGRGGRRSSAFRRESWRKSMERSSDSAFSSDYRSNVAPSDSDRELTSRRDSDQQRLHSHHSHHQPHHPSASPAVPKLGLMAPSADSESGGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLDSTKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQPTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYPEGIADAVASKEEEDEERADSPVSSSSSRSDLSSPSFNRDSEFDFQPKGGQTLGSTTVGSGAAAPSFELATPLAMRLEATIKMASIEQESDTVSTATGKTIAAGSKLQRHPSDSESRPEKKIPPPLTPPVKQPGVSNILARTGSSGSSSSSPGRQSSQSSLFENFASHAKELVRETTRQSSQEGLLAHVDKFTLHAKKAAGEASKQALEVSKQAAGVSKNTLEDLTYVGKSTLGDLTKTAKEAATKKGIIKIEEHSAGGAGPPPKSPGSQLATHKQVQQSGGQGGGNNFFSAIGTDFNGLASSTSTMFSGMFGKKSQQKQVPVQQKQPNVSAGKAKSGINFDPFPGRKGLVERTPLIKHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKIAPDDHIDDVCVTKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKEINEGSDMSSSLLSSHAASPMGSRENLRSPSSPNGSHSALGSEWASPQESRKSSTQLAHGGPGGSHSGAPINRRLSSADSQDGQSTTEMFKDMLSQKRSALKNMLTSFDSDTTTSKDSKKSSGNLWSGKSTLSAGFRYTGGHLINTSSSPSPDSPRVYLFEGLLGKDRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMSDQICYSVLCVFSYVAAGQDQKKNPVVITPQIQDIHAQQKQKHQQQQQHQQPQQQQQPHQTTTQQNQPTAVASAVPTTTAPAGQVNPNRMTAKSQAGSISIRHTVPMQKPTITMSTVQPQARMPAQVATASVPVTVPVPPTPAPPTSNPAKLPQLPPRVPSQPSTESLASISSPPPKLRTPMSAPPGPPPAIPPRTGAISRSGSVPAARSFVRQASANSTPPQYTPQPPPPFVIPKRHSGLARASTLSSSTSPSMSSSSASNHPGHSQSQQRASHGSVAAVLQSMPEAEPGYGSGSGSISGSSSGSGSASGSIASASPQAHRKH
The following text describes a protein:
Function:
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (By similarity). Promotes ubiquitination and degradation of SLBP (By similarity).
Miscellaneous:
MISCELLANEOUS: Insertion of the beta Geo promoter trap into the Fem1c gene is the cause of ROSA3 mice. Adult ROSA3 mice exhibit widespread expression of the trap gene in epithelial cells found in most organs. Although normal processing of the Fem1c transcript is disrupted in homozygous ROSA3 mice, some tissues show low levels of a partially processed transcript containing exons 2 and 3, which contain the entire coding region of Fem1c. ROSA3 mice show no adverse effects in their sexual development or fertility or in the attenuation of neuronal cell death.
Domain:
The first seven ANK repeats at the N-terminus (1-242) are essnetial for recognition of Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons.
Sequence:
MDLKTAVFNAARDGKLRLLTKLLASKSKAEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTVEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGNIPEKLETFVSLHR
The following text describes a protein:
Function:
Putrescine importer. Required for induction of type 1 pili-driven surface motility.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSHNVTPNTSRVELRKTLTLVPVVMMGLAYMQPMTLFDTFGIVSGLTDGHVPTAYAFALIAILFTALSYGKLVRRYPSAGSAYTYAQKSISPTVGFMVGWSSLLDYLFAPMINILLAKIYFEALVPSIPSWMFVVALVAFMTAFNLRSLKSVANFNTVIVVLQVVLIAVILGMVVYGVFEGEGAGTLASTRPFWSGDAHVIPMITGATILCFSFTGFDGISNLSEETKDAERVIPRAIFLTALIGGMIFIFATYFLQLYFPDISRFKDPDASQPEIMLYVAGKAFQVGALIFSTITVLASGMAAHAGVARLMYVMGRDGVFPKSFFGYVHPKWRTPAMNIILVGAIALLAINFDLVMATALINFGALVAFTFVNLSVISQFWIREKRNKTLKDHFQYLFLPMCGALTVGALWVNLEESSMVLGLIWAAIGLIYLACVTKSFRNPVPQYEDVA
The following text describes a protein:
Function:
Essential for mating and for recognition of the mating pheromone, and for the determination of cell shape. Implicated in activation of the ras1 protein.
Sequence:
MSEVKRNISLRNSTNIFTSTFSLSSNNVPKPLIGESVIKYGDEAFVYGGRDALNAQLVNDMYVVDLNTCSWKQVEYQGNQKPIPRYFHSGDLWNNKLIFFGGMGFNDDTKCLYVLNDIDIYDIETKQWSHIPGMITENQTNDDAKEVNGSDVDEKSKHLYPSARYGHLHCVLDHYLIIFCGQDLSNSYIEEINIFDLDSGKWVFKSLFNHHCGIYRSNCVVINKDSEFLQMCRPINTTQDSNEHSIGSLFFYLNYNFVNVKRQVIYLELFELDTAESEKKSAALAKDNNQSFRFLELDVTEKFLSSAMPPGLRFPAVNILGDNLILSGIYLTSSRQAFVLWVYSLDKELWLQLDMLGVLNHGSWFKCLVLDCTNRFVVFGNKTRKLTQDYNLRQSNYDHIVFIELEGYGVYRKPQMGRVTERSEQLGKLLLNGISDMEILTIERMHIPCLSRMLYKRWPAFQKIMDRAVEKNQEAFQAEVSQLGPQLTDLPFSSIHSTGSRALYMPYSFETCSAFLHYIYCGTLNGSYCTAKNLCNLLILCKGFEGLETFFAYIVHLLHGVLNRNNVKLIYETAALTGAKGLQLRALRRIARIEQGGTAISPTSPLPNLDD
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MDPSIIGSLHPHEQQQLMSTLEAQQMEQAMQFNTHLIEHCFNACINDFTSKVVSKKENTCVTRCVDKFTNYSKRLSLRFQESYQERQNEFQGNE
The following text describes a protein:
Function:
Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MALRRGDQVLKRLSPRISLLCSRLLAPEQSLLDRESSHGFATTSGNWQGASGRDDAADFGYKKVSREEKTTLVGEVFKNVAPSYDLMNDLMSGGMHRLWKDRFVKKLHPFVGMQHLDVAGGTGDIAFRVLDAIREQEPKQEQAAWGPRSSVVVCDINPAMLEVGKKRAQERGLGEASGLQWVEGNAEKLPFEDASFDTYSIVFGIRNVTDIEAALREAHRVLKPGGRFLCMEFSQVRSPTLRALYDAYSFSVIPVLGDVVARDRASYQYLVESIRKFPSQKKFASMIAAAGFQEVTYENLVAGAVAIHSGFKL
The following text describes a protein:
Function:
May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNWYVRLLQKYPYRMAVTSTSSLFMIGDCVSQRYFSDKPYEPMRTARAGIYACAFAPAMTAWFRFLGQQQLPVIAKVAIDQAVFAPSSIGYYFSVMGLLEGKSPDTIWQSLKNQYWDTLKCGWMIWPAFQLFNFGIVPPNFRVLASNCCGLVWNTFLAYQNANKMEKGHVADLVIEEVKEEVKEVKQEVLAEVKVIKGFVKQ
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MLGAFRRSAVSHALRSCPRTLSARSSPQRLQFLYSSISGPSSTSKSLFHSGQFRFSAQVNAVAENSSQNVSVEELPTRFAELGERNILPRNLVENLTKHMKLETMTEVQRRTILESVKGGDMLAQAKTGTGKTVAFLIPVVEKLLGDRSLLKTSYRNGRKIAPIDIRAIVISPTRELAEQIAVEAKRLVARTGLQVQVAVGGTMKRAALHQLQREGCHILVATPGRLKDLLTDPTSGVRAPKLNTFVLDEADRLLDEGFAPELMEIQHRLPDPAEVDRQTLMFSATVAPEVMGMVRSTMKRDFRFVKCVRDDEVPTHMSVPQKAVILQGLENAMPTLLELVKKSYDPRSTFKAIVYFGSTRETNTAFEAFDQLLAQRTRVANWFRKCQSGILFSTDVTARGMDFPNVTHVIQIGVPKTREDYIHRLGRTARAGKTGQGWIFIHEQQMGTLRKLLRDIPVEVDRETLTIPSLKLTEESPSTTPEATETLLQMKSGFAQVSRATKSETCLAQLSNLVGSFRNRSLLREAITNLAIHGYGLRDAPHIPSSMAEKAGLDRESGFSIRNYKPSQRHRQDSAQGHNNYGDRRRSFNDRRPIRNNDFYPNRRAARSSGRQGSGARERHGAPSAERFDKWLDNRKDEWA
The following text describes a protein:
Function:
Component of the transport system for branched-chain amino acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKTSSKDFIVIGFALFAMFFGAGNLIFPPFIGNLVGDKAPIAIIGFLITGVGLPLSAIIACAKINGTFSDISGRVGKYFSVISTTALILAIGPMLCIPRTAATTYELTVQPLFPSIGPLVSAIIYFAICLAFVLRPSGIVDSIGKVLTPCLLLMLAIIIIKGLISPLGPVVSTNFKGVFSTSLLEGYQTMDTMGSVIYASIILASVRSKGYTDEKDVISVTIKSGIVAIAGLGLVYGGLMVLGSQTSQIISGEEIGRTALVIEIVKRDLGNIGIVILGIAVGLACLTTAIGLLSTGAEYLSKLTKGKVSYNAFAIIISVVSGILGIGGVDKIIKFSVPILQILYPIVIVLIVITLLGKVVKNDSVVKFTVYITLIVSMIDTMNTLTGEKVAFIKSILGIIPLSSVGFAWLIPAIIAFIIGTIAFGNKQEKNPQAADF
The following text describes a protein:
Function:
Involved in the degradation of long-chain fatty acids.
Sequence:
MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDYIEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKFSRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDALGAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVSTGPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGASKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMSQFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVERAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPGSGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVLRTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRKLTRVTPKNVIQKKREAAAGIFEAEKYTV
The following text describes a protein:
Function:
RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif. U6 snRNA processing is required for spermatogenesis (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm.
Domain:
The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.
Sequence:
METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD
The following text describes a protein:
Function:
Cleaves both heparin and heparan sulfate glycosaminoglycans through a beta-elimination mechanism. Cleaves heparin at alpha-D-GlcNp2S6S(1->4) alpha-L-IdoAp2S and heparan sulfate at alpha-D-GlcNp2Ac(or 2S)6OH(1->4)beta-D-GlcAp.
Subcellular Localization:
Periplasm.
Sequence:
MKRQLYLYVIFVVVELMVFTTKGYSQTKADVVWKDVDGVSMPIPPKTHPRLYLREQQVPDLKNRMNDPKLKKVWADMIKMQEDWKPADIPEVKDFRFYFNQKGLTVRVELMALNYLMTKDPKVGREAITSIIDTLETATFKPAGDISRGIGLFMVTGAIVYDWCYDQLKPEEKTRFVKAFVRLAKMLECGYPPVKDKSIVGHASEWMIMRDLLSVGIAIYDEFPEMYNLAAGRFFKEHLVARNWFYPSHNYHQGMSYLNVRFTNDLFALWILDRMGAGNVFNPGQQFILYDAIYKRRPDGQILAGGDVDYSRKKPKYYTMPALLAGSYYKDEYLNYEFLKDPNVEPHCKLFEFLWRDTQLGSRKPDDLPLSRYSGSPFGWMIARTGWGPESVIAEMKVNEYSFLNHQHQDAGAFQIYYKGPLAIDAGSYTGSSGGYNSPHNKNFFKRTIAHNSLLIYDPKETFSSSGYGGSDHTDFAANDGGQRLPGKGWIAPRDLKEMLAGDFRTGKILAQGFGPDNQTPDYTYLKGDITAAYSAKVKEVKRSFLFLNLKDAKVPAAMIVFDKVVASNPDFKKFWLLHSIEQPEIKGNQITIKRTKNGDSGMLVNTALLPDAANSNITSIGGKGKDFWVFGTNYTNDPKPGTDEALERGEWRVEITPKKAAAEDYYLNVIQIADNTQQKLHEVKRIDGDKVVGVQLADRIVTFSKTSETVDRPFGFSVVGKGTFKFVMTDLLPGTWQVLKDGKILYPALSAKGDDGALYFEGTEGTYRFLR
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MISKNTSFCGFLILVLATCMSAQFVSNESIKLHDILKPSATHRLFDTLQYSVEEQYSDSHLSFDVSTIYNYSEKPISIGKLNKKYRDILFEGDMAISYKQLSMIVNGSTEYRKAIKSRRRGNKINGESTDRTKRQAYLDNNYPATIWKNGVAFMFHESLTPIAKTAILKAVHFWYRETCIEFHPRTFQKEYLLFIGNDDGCWSTVGRDASQGKQVVSIGNGCEHFGVTSHELAHALGIFHEQSRFDRDESVVFNPRVVERDLLFNFAKISPRQMSTYGLPYDIGSVMHYTPTEFSNIPSIPTLAAIDTNLQQTMGQLEGPSFVDVHIMNQHYQCQEKCPTQAPCQNGGFTNSRNCKVCKCPTGFGGAYCQLIASSFSPFCGGYLNAEETTRRFDITIRQSTTTRSKTCVYHIKAPEGKRIIIDILKIDSKCIEGCWQDGLELKMKKDFRPVGYRFCCPESSRRKVISEGNMVPFMVFSKEHDFSVSFEYSFVSTSAGFDDEKNDSDVIVDNLDGVFVSDTSLLQRIGFRRQL
The following text describes a protein:
Function:
Required for nuclear pore complex assembly, maintenance and function. Required for nuclear import of phosphorylated Mad via importin msk. Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta. Mediates the association between the nuclear pore complex and a subclass of silenced regions bound by Polycomb group (PcG) proteins, enables long-range interactions between Polycomb loci and contributes to repression of polycomb targets. Together with Nup62 and Nup154, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells.
Subcellular Localization:
Nucleus membrane. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Note=When not in the nuclear pore complex, can localize to the nuclear lumen proximal to the inner nuclear membrane.
Sequence:
MDLMELLKQAQRLTNETNTDTEVPGVERTMSQVLQATKEFHSRVTQMGTNDLQAHILLGSKGVDLPKLTQKLESLSARQTFEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSEWGEEKEALLNALVGPNQQDFPDVQFQIVPTAMADEPTPYSQLNGHEQMYAEQIAIHNQSIILGRRPNLLSTLAHVVQDSFNDESVAEMWNVLQFMTALPPVSSTIDPIKNRQTSPQFVEQARTYLERRYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVNNGQPLWPHVYYSLRSGDMDAAALYLKESGTCPDLLTLLTLRKNGDRDNLMVKLEGQLKLEYNSRLRACTDPYKKAVYVVLLACDPHFTHVELMRSIDDFLWMQLSILRRSDQSDSNTEQLTFSGLQSLILEKYGENYFNAREKAALYFQVLTLTGQFEAAIEFLARTEKNRTHAIHMAIALNEISMLGTPRSVEQSLLSSDPDDPKPMKRLNLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDLLVEKCDDEMLELIFGTEDKKNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFIGGQLDKALRLVNSLLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRKSDVEVQVVVTYTVLTKVMKFFDHYHEGALRSALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVYQEYVKLMDSNETASGFFDESKCVNKEPAVKHLRDRAKAFTNMAASVPYRMPSTTNQRLVQLEILMH
The following text describes a protein:
Function:
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
Sequence:
MDYFPIFCQLQHKACLLVGGGEIAERKARLLLDAGALVTVNACEFTPQFHHWADQGQLSLISGEFVPELLADKWLVIAATDQLSVNALVYQSANQQRIFCNVVDDPKRTSFIMPSIIDRSPIMIAVSSGGKAPVLARLLREKLEALLPQHLGQLAGNLRQRVKQHFTVMTERRRFWEKLLTHDRLAQSLANNDHVQADQHVEQLFSAPLTDRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDEVMNLVRRDAERIFVGKQSGHHCVPQEQINQILLQQAQSGKRVVRLKGGDPFIFGRGGEELEELAGYGIPFSVVPGITAASGCSAYSGIPLTHRDHAQSVRLVTGHAKKEGQLDWANLAAEKQTLVFYMGLSQAGEIQQQLIQHGMPATTQVALVENGTSRHQRVVSGELSQLALLSQQVSSPSLIIVGSVVSLREKLNWFSSRHHDDQPKVTECVAHVG
The following text describes a protein:
Function:
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Sequence:
MSKKYHQKAYTAEEKRKAIQMYEEKIHYSARYSNDEWEFRHVIIPKPLVRFIPPGVCAEEVWRGIGIRQSPGWEMYMRHEPEPHVLLFRRPKNYDQIHRPFSQTLAARKLNISREVTAHPAPAK
The following text describes a protein:
Function:
Has a role in the progression of DNA replication and in the maintenance of genomic integrity. Acts during S phase, after initiation, where it is essential for completion.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDFPGLIKKIKEDLENRLVEKSKQPAFTDYWLINKTISLLKEYPSGFSYPILINEIELACSERNKLDNVFSSLEWLTKSDAVIYLEDQFHFHCYDYYYTPIPSLKLKDSEENTCEMILHSSFYLLFHEPFNILKGSTLRFSQSRIHQKWYLRKQIRFLPTTSFVPVLQYAASKSFVKSMVESTEHEFFQIRDITISKSDQGVKRITVELGRIISLDKKGAFLIDNNTNFIHFSGTYHDFPKLLDKQQYLLIPFWSTVWEGSTNWQDGMIGILVILSENDFEEKKCDSWQVGRLAAVNSNFLVLDNNGQRVKILYSNSQKHYFKDTYIGDLLCISPINHSSDNLSDYSCVSDTTTEILSNLENPLSSNFLRNDLCKFSNLFSGVSGHLKIQPLTLVITGFVANLTRQSDLNTSLVLPEVNPLTAKMEVIDCLRNSFWAALRPNCVSYFASMISGFKELFQKEMEFPIYLDLKSYKLGFHWCDIYVDSEHNCHIQKINSLPCE
The following text describes a protein:
Function:
Functions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29.
Miscellaneous:
MISCELLANEOUS: Present with 1480 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MAVDVPRAVINKLMLFTAAMVVLPVLTFFIIQQFTPNTLISGGLAAAMANVVLIVYIVVAFREDTEDHKVDGNKKED
The following text describes a protein:
Function:
Chaperone that expresses an ATPase activity.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Mitochondrion. Spore, perispore. Nucleus, nucleolus. Note=Localizes to the cortical actin cytoskeleton. Translocates to the mitochondrion during the prestarvation response and in response to differentiation. In prespore cells, colocalizes with grp94 in the prespore-specific vacuole. Found in the outermost layer of spore cell wall.
Sequence:
MQRTLSKVILNSGKNNLLKSSNLLNSNLLKATTTNIIGIKTINNNNNVNSIIGFKSLNKRYFTSNTPKVEEEDDEIAPDEAIKAEEKIKETERVIGLSEKLSFQTETQKILHIVAESLYTEKEVFIRELISNASDAIEKVRHTQLTNASMIEDASIPFEIKISTDEDNKTLIIQDSGIGMTKDEMIKNLGKIGYSGSSDFIKKLGENPDKASIIGQFGVGFYSCFMVGHTIKIYTKSATPGSKGYLWESDGTGSYSITEAEGVSRGTKIIIHLKPSSYEYSKKSIVENIIKKYSNFVGFPIALNGTTVNTIKPLWTLNKNAISEEEHKEFYQFLSKSYDTPSYRVHFSTDTPLSIRSIFYIPSQHMEKYGMGKMEPGVSLFSRKVLIQQKANGILPEWMRFVRGVVDSEDIPLNVSREHLQDNGLIQRISSVLVKRILKHLNDEAKSDPEKFNVFMTEFGGFFKEGIITDFKWKDEISKLLRFESSNGSTASKTDAVSLEQYVSRMKPEQKNIYFLSVPNRAVGLSSPYYEPFQLKDIEVIFLYNAVDEFVLTNVGHFGDKKIVSVESKEAEEFLATNQDKKTETLSQDEIDKFLSWVSTVASDKVTQAKSTTRSISSPAIIIDHESANFRRMLKMVEPGKQHETPKQVVEFNMNHPIILKLVQQTESNPTIAKLVIDQVVDNAFVSAGLIEDNREMIPRINQLLDSLLTK
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MWQAQICICAILLAAWTRGASVPGPSAQASLPPRADDAWSVLDQVLAPTTLEAFLRHDYRRNLRHVRATSSRNLSSLDPWIERLCNVDAFMGETFSQLRAVPGAVQYKTATGSDRPLPPTPTWTEEAPRFYASGESMVLRREATTAPLSDLELALQTVFHTTHSTVHAYISSGGAQALPYHTDSYDVIVLQVSGVKKWTICQPPSLETAWPNPSPADLAQLYELRHANPDGCSNFNHRTIEQLNCQNLTMLAGDMLYLPKSMIHVAHTKPGTVSAHLTYSLDREGGMWRDVISRACSTWRLPLCPEILGSLQRAKSTDAALPWLQLAYEPVRPGAPVTSTHCLRLYSMVFGKEFYSLASLLSPRPGLLGYLSTLQRNWQLAILAECHAEQAGYTMRSFIETPEASVSDVRMRRNVFPYNPPCNSNGGYCLNCYQSSCNNGCSGIDACDGYVRFVCLPDIEPPNPPLLTLRVGRVAH
The following text describes a protein:
Function:
Endopeptidase which plays a key role in innate immunity by cleaving Tl ligand spz and thereby activating the Toll pathway in response to fungal and Gram-positive bacterial infections. Acts downstream of pathogen recognition receptors PGRP-SA and GNBP1 and protease grass in response to Gram-positive bacterial infection. Acts downstream of protease psh in response to fungal infection.
Subcellular Localization:
Secreted. Note=Probably secreted in the hemolymph.
Domain:
The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Sequence:
MASTERNFLLLSLVVSALSGLVHRSDAAEISFGSCTPQQSDERGQCVHITSCPYLANLLMVEPKTPAQRILLSKSQCGLDNRVEGLVNRILVCCPQSMRGNIMDSEPTPSTRDALQQGDVLPGNDVCGFLFADRIFGGTNTTLWEFPWMVLLQYKKLFSETYTFNCGGALLNSRYVLTAGHCLASRELDKSGAVLHSVRLGEWDTRTDPDCTTQMNGQRICAPKHIDIEVEKGIIHEMYAPNSVDQRNDIALVRLKRIVSYTDYVRPICLPTDGLVQNNFVDYGMDVAGWGLTENMQPSAIKLKITVNVWNLTSCQEKYSSFKVKLDDSQMCAGGQLGVDTCGGDSGGPLMVPISTGGRDVFYIAGVTSYGTKPCGLKGWPGVYTRTGAFIDWIKQKLEP
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Sequence:
MKIMISQVGRELYKVPLRILDHRVFVNGEIEAFLENFEVRRNDSEVEKLFQVTETVGSLKYDLSRCSATGRGSGAENLAQLDTEVSHLLDGVNALLAKAKVERTASTQLQEARLAREQRRAEFLTNLEHGYRRIENSFEEKEEEIAELYSDLQLKLNIAK
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MSDVSKFVRQLERLVETGAEPSKILPAIDKILFVGSKNTFALRCKVVCLLHQDKHAAALATLEQLAATDPSLGNKSQEYAFHKAYCHYRLFDDRQAQMVLSRAPHTANHVPSQHLLAQAHYRLEEFEEAANIYEELLKNERFRDEQEKAELLTNYTAACTAMDVQRTQAIVRSADVKNADMLYNVATAQLEVQDYAAATQTLKQAEMVCARAHPESQLRSFEDVCSKVDDELRALLDAKGSPERAFFDDVANIWVQMAFVHHAIHHEEKAAALLTFVLKYRPPSEVTLAVASINWAAIQRHKDFFDTYRKLKSAQNPAVNNRLTSRQRLLVHYNIAMLLLNTGNFTRFKRQVELVASDYPDADLTHALKLALAVGETKKKKQSGDKTVSEYLDNYKKSVAAQQQQQQRKPAVGRMLPLIAAQIFLDNSDLERAIESLSSAADDIQRRPCTLMTLFTWKVQLGDISGGKQLLKEYAGAAMKNVDVVKTITLWAVRFLSARGLYADGVDVIQDAQRVAAALQQDREVLALMALCLSYYDMQAARSCIAGIPDADNKTGAPSGKITSSFIKELEAQQPSRQRIESFGYRRVVEDDEEGDGGPKAKRAGRRARPMRRPPKNAESRIDPERWIPMSHRSYIKDLPERRKRELKRLRAIEQEQKRRLAEKRKVATATADPSS