lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex. When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids. Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components. Links the microtubule cytoskeleton to chromosomes during interphase. Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Sequence:
MNANKQRQYNQLAHELRELQTNLQETTKQLDIMSKQCNENLVGQLGKVHGSWLIGSYIYYMEQMLGKTQ
The following text describes a protein:
Function:
Acts as a membrane-bound chaperone in endoplasmic reticulum quality control. Probably facilitates presentation of substrate to membrane-bound components of the degradation machinery.
Miscellaneous:
MISCELLANEOUS: Present with 6020 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MKMNLKRLVVTFFSCITFLLKFTIAAAEPPEGFPEPLNPTNFKEELSKGLHIIDFYSPYCPHCKHLAPVWMETWEEFKEESKTLNITFSQVNCIESADLCGDENIEYFPEIRLYNPSGYIKSFTETPRTKESLIAFARRESMDPNNLDTDLDSAKSESQYLEGFDFLELIAGKATRPHLVSFWPTKDMKNSDDSLEFKNCDKCHEFQRTWKIISRQLAVDDINTGHVNCESNPTICEELGFGDLVKITNHRADREPKVALVLPNKTSNNLFDYPNGYSAKSDGYVDFARRTFTNSKFPNITEGELEKKANRDIDFLQERGRVTNNDIHLVFSYDPETVVIEDFDILEYLIEPLSKIPNIYLHQIDKNLINLSRNLFGRMYEKINYDASQTQKVFNKEYFTMNTVTQLPTFFMFKDGDPISYVFPGYSTTEMRNIDAIMDWVKKYSNPLVTEVDSSNLKKLISFQTKSYSDLAIQLISSTDHKHIKGSNKLIKNLLLASWEYEHIRMENNFEEINERRARKADGIKKIKEKKAPANKIVDKMREEIPHMDQKKLLLGYLDISKEKNFFRKYGITGEYKIGDVIIIDKSNNYYYNKDNFGNSLTSNNPQLLREAFVSLNIPSKALYSSKLKGRLINSPFHNVLSFLDIIHGNGMPGYLIVIVLFIAILKGPSIYRRYKVRKHYRAKRNAVGILGNMEKKKNQD
The following text describes a protein:
Function:
May dephosphorylate and repress plasma membrane H(+)-ATPases (PM H(+)-ATPases, e.g. AHA1 and AHA2), thus influencing negatively plant growth and fitness.
Sequence:
MLSLFFNFLTSCLWPSSSTTSHTYSDSKGKQDGLLWYKDSAHHLFGDFSMAVVQANNLLEDQSQVESGPLTTLSSSGPYGTFVGVYDGHGGPETSRFVNDHLFHHLKRFAAEQDSMSVDVIRKAYEATEEGFLGVVAKQWAVKPHIAAVGSCCLIGVVCDGKLYVANVGDSRAVLGKVIKATGEVNALQLSAEHNVSIESVRQEMHSLHPDDSHIVVLKHNVWRVKGIIQVSRSIGDVYLKKSEFNKEPLYTKYRLREPMKRPILSWEPSITVHDLQPDDQFLIFASDGLWEQLSNQEAVEIVQNHPRNGIARRLVKAALQEAAKKREMRYSDLNKIERGVRRHFHDDITVVVLFLDTNLLSRASSLKTPSVSIRGGGITLPKKL
The following text describes a protein:
Function:
[Isoform B]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein coupled receptor signaling. Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine. Has no role in bitter perception. In the circadian brain neuron evening cells (E-cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases; [Isoform C]: Does not have adenylyl cyclase activity and it is not involved in taste perception.
Miscellaneous:
MISCELLANEOUS: [Isoform C]: Catalytically inactive.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Sequence:
MDVELEEEEERICLRTAEEGQLANMDDDKLVSDEVHLRQLSATPSSAFSLQHSRGSDTKEEAPPEGGTMGGKSAAPREEGEPDERVVLRRAVDKGAIALAQIDDLKLEGDDDDEAVVNGEEVDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSEQDAASTAMATPDMSKIPRLPGDGAQMEDNGSGDLPPSLRASTTSILSNLRKKQQGGPLRGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGTPSPQIRRGHRGSTFSSVRLSQKSTTVNPVRRNTTRVRGRSYRQKKSSSNNSIVTQASSSYMPSFRRIDQIETTISKSHNDAL
The following text describes a protein:
Function:
Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.thermoresistibile. Trehalose uptake is essential for virulence (By similarity). Binds deuterated trehalose with similar high affinity to trehalose, trehalose analogs including galactotrehalose, 4-azido-4-deoxy-trehalose, 6-azido-6-deoxy-trehalose, 3-azido-3-deoxy-trehalose and mannotrehalose in the order of decreasing affinity, respectively, and 2-azido-2-deoxy-trehalose and kojibiose (alpha1,2-glycosidic bond) with very low affinity. Does not recognize single glucose, 6-amino-6-deoxy-trehalose, trehalose-6-phosphate, nigerose (alpha1,3-glycosidic bond), maltose (alpha1,4-glycosidic bond), isomaltose (alpha1,6-glycosidic bond) or glycerophosphocholine. Decreased recognition of alpha,beta-trehalose and almost no recognition of beta,beta-trehalose. Substrate specificity indicates a strict requirement for an alpha1,1-linked disaccharide.
Subcellular Localization:
Cell inner membrane; Lipid-anchor; Periplasmic side.
Sequence:
MDGRQVVRARRWCATAAVALMTASTVAACGSDSGEIVISYYTPANEAATFTAVAQRCNAELGGRFRIEQRSLPREADAQRLQLARRLTGNDRSLDVMALDVVWTAEFAEAGWALPLSEDPAGLAEADATTNTLPGPLETAKWNGELYAAPITTNTQLLWYRADLMDEPPATWDEMLSEAARLHAQGGPSWIAVQGKQYEGLVVWFNTLLESAGGQVLSDDGQRVTLTDTPEHRAATVKALEIIKAVATAPGADPSITQTDENTARLALEQGRAALEVNWPYVLPSLLENAIKGGVGFLPLNENPALRGSINDVGTFAPTDEQFDLALNASKEVFGFARYPGVRPDEPARVTLGGLNLAVASTTRHKAEAFEAVRCLRNEENQRLTSIEGGLPAVRTSLYDDPQFQAKYPQYEIIRDQLINAAVRPATPVYQAMSTRMSATLAPISQIDPERTADELAEQVQQAIDGKGLIP
The following text describes a protein:
Function:
Tautomerase that converts enol-oxaloacetate to the keto form of oxaloacetate. Also shows weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2).
Subcellular Localization:
Cytoplasm. Note=Localizes in the form of helical filaments that run the length of the cell.
Sequence:
MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLIECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYRDHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGTRISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPERLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTPPKFLRSGDKIDITIDPIGTLSNQIG
The following text describes a protein:
Function:
Structural subunit of the minor fimbriae. These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. They play an important role in invasion of periodontal tissues and are recognized as major virulence factors. Mfa1 orthologs from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).
Subcellular Localization:
Fimbrium. Cell outer membrane. Note=Probably synthesized as a palmitoylated precursor. Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide (Probable).
Sequence:
MKLNKMFLVGALLSLGFASCSKEGNGPAPDSSSTADTHMSVSMSLPQHNRAGDNDYNPIGEYGGVDKINDLTVYVVGDGKIDVRKLSTADLQVNQGASTTSIVTAPFQVKSGEKTVYAIVNITPKVEAALNAATNAADLKVAYEAAYAAFSDAGSEIATLVNNQDQMIMSGKPVVQTILPNVSAANASVQNKVPIIVKRAAIRASMTITQQPVNGAYEIKALRPGNVEVVIATVSDLKWSVAQYEKKYYLQQKDNALSPAASFVPASTNDYNGANGAMKHYDYSQLANRITVHQLNAPYSVTDVPNVAYKYVSETTHADNDYRKGNTTYILVKGKLKPVAAMWADGEQAAYQEGGDLFLGLVTGKFYANEANANAANPASGGAGNPRVVTYKAAAVYYYAWLNPNTLDPTTWTMSPARRNNIYNVNISKFRNIGLSGNPFVPTDPDPNNPDTPDNPDTPDPEDPDTPNPEEPLPVQKTYMVVDVTVTPWTLHNYDIEF
The following text describes a protein:
Function:
Plays a role in regulating magnetite crystal size.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)).
Subcellular Localization:
Magnetosome membrane; Multi-pass membrane protein. Note=Localizes as a filament-like structure in a straight line running through the center of the cell, in a position that corresponds to magnetosomes.
Sequence:
MIKGIAGVGGTALGVGGGVAAPPVSAAAVGSTLLAGKGVCLGLGLGLGAWGPVLLGVAGLACAASLCDYLKNRKAQAEASAEPA
The following text describes a protein:
Function:
Urea channel that facilitates transmembrane urea transport down a concentration gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFGEQLLKNPLIEFCDSVCRGCGQVMFQNNTVTGLLFFAGIFYNSTTLGVCAVLGTAASTLTAQLLGVDKPLVRAGLFGFNGTLAGIALPFFFNYEPAMLGYVALNGAFTTIIMASLLNFLGKWGVPALTAPFVLATWLLMFGVYKLSLFHPGALIAPALPSVAGLADMGTVTGRTFMEGLFKGVGEVMFQDNIVTGVIFVVAILVNSRISALFAVIGSLVGLCTALIMHSPETPVRLGLYGFNSVLCGIAMGGIFFYLNIRTFLYALGCMVLGAIATGAFSVLLSPIGMPALTWPFIVVTWLFLFAGSMFRNIAQVPTEKAGTPEDNLRSLAIGSR
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Subcellular Localization:
Cytoplasm.
Sequence:
MPKLILASTSPWRRALLEKLQISFECAAPEVDETPRSDESPRQLVLRLAQEKAQSLASRYPDHLIIGSDQVCVLDGEITGKPLTEENARLQLRKASGNIVTFYTGLALFNSANGHLQTEVEPFDVHFRHLSEAEIDNYVRKEHPLHCAGSFKSEGFGITLFERLEGRDPNTLVGLPLIALCQMLRREGKNPLMG
The following text describes a protein:
Function:
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MATISNLANLPRATCVDSKSSSSSSVLPRSFVNFRALNAKLSSSQLSLRYNQRSIPSLSVRCSVSGGNGTAGKRTTLHDLYEKEGQSPWYDNLCRPVTDLLPLIARGVRGVTSNPAIFQKAISTSNAYNDQFRTLVESGKDIESAYWELVVKDIQDACKLFEPIYDQTEGADGYVSVEVSPRLADDTQGTVEAAKYLSKVVNRRNVYIKIPATAPCIPSIRDVIAAGISVNVTLIFSIARYEAVIDAYLDGLEASGLDDLSRVTSVASFFVSRVDTLMDKMLEQIGTPEALDLRGKAAVAQAALAYKLYQQKFSGPRWEALVKKGAKKQRLLWASTSVKNPAYSDTLYVAPLIGPDTVSTMPDQALEAFADHGIVKRTIDANVSEAEGIYSALEKLGIDWNKVGEQLEDEGVDSFKKSFESLLGTLQDKANTLKLASH
The following text describes a protein:
Function:
The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSRAKAKDPRFPDFSFTVVEGARATRVPGGRTIEEIEPEYKIKGRTTFSAIFRYDPFDFWVGPFYVGFWGFVSVIGIIFGSYFYINETILKGPYSIPQNFFAGRIDPPPPELGLGFAAPGEPGFAWQMTVLFATIAFFGWMMRQVDISMKLDMGYHVPIAFGVAFSAWLVLQVIRPIALGMWHEGFVLGIMPHLDWVSNFGYRYNNFFYNPFHAIGITGLFASTWLLACHGSLILSAAQYRGPEGGDIENVFFRDVQYYSVGESGVHRLGYIFAIGGILSADLCILLSGWPVQDWVSFWNFWNNLPFWSGV
The following text describes a protein:
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MVVSKQEAISFSVTSLGWVGAIVSCVLPVWRVTFPDDETDPDATIWEGLWHICQVRENRWIQCTLYDTRILVAQDIKVSRVFMVICTIGTWLGLLLCVLGDWRINCFMNFTIEENLLKVAGGMFLSVGLLMLVPLSWVTHNIIHGFFNPLLGFSKKVQMGSSLSLAWTSSLLLLLGGILLCVNIPVCRDFPRCIETPSARPSGANNDTLDV
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQWNNVELTNMSKKSYTLNHAYDAAEKLNKENTAKSSNGNGTSADESTAADGDLLKPGSDVRPKVEPEDVESLLRRLYGITISEVKEIVAYDDRNFFVKEDSNVKNPLIVTHCPHGYVLKILNSLDSKKEDFVDAQNQMLLYLGKHSVKCPRPVANATGKYYSVERLNGNSNVVRLLEFIPGEIFHQVPVTKHLLYRSGEYLARLDRALKNFTHQAYESHKTLWMLQSVPELRQFLYVVKDQEQRLICDEVIDAFEAKVLSQLPSMEHQIIHGDFNEQNIVVEQVPNQTEYTIKGVIDFGDTSKSPLIFEIGIALTYMILQANDLANGGIFLSGYTSLNPIENSELALLKYCVTARFVQSLVMGLYTHTLHPTNEYLLVTQEKGWKLLQKLWRESFDDIDELWASTGHQYLTQSNK
The following text describes a protein:
Function:
Involved in the negative regulation of organ growth. May act as a negative regulator of auxin synthesis and transport.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing SAUR39 display reduced shoot and root growth, altered shoot morphology, reduced size of vascular tissue, low yield and decreased basipetal auxin transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MPLQTIHKLKHQYTHNKSSSHQKKHTMINPKRLVHLAKKWQHMAALGRRRLTITGATKEGNLRCSSAIADKGHCIIYTADGERFGVPLTYLSTTVFGELLRLSEDEFGFTGEEKITLPCEAAVMEYVMCLLRRKPSEEVEQAVVSSVVMPCNYKSSTSMVSVNLSQSLAIF
The following text describes a protein:
Function:
Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MFVSYLLLTLFHTETAMLARPGGESIGCDDFLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGNNAISPQVPPHRRPGEPFNGQLETEDGGQEDREEREKNQEKEDSHVEAPEVFTSESTQTFPVRHPERFPSHRPDNLVPPAPQHPRRNRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPTPEEEPCNLFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQTRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHISSLPLEGCGNNRPAEATPCDNGPCTGKVEWFTGSWSQCSVECGSGTQQREVICVRKNADTFEVLDPYECSFLEKPPSQQACHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTPGSLCDPQLKPEERESCNPQDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANRHTGFLGSR
The following text describes a protein:
Function:
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Plays a role in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides, including cAMP and cGMP. Mediates the ATP-dependent efflux of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates, such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Plays a role in the transport of earwax components. Participates in the secretion of odorants and their precursors from the apocrine sweat glands, including the secretion of glutamine conjugates, as well as the Cys-Gly-(S) conjugates of 3-methyl-3-sulfanyl-hexanol. Involved in the cellular extrusion of nucleotide analogs, hence confering resistance to various drugs, including clinically relevant drugs such as 5-fluorouracil (5-FU) and methotrexate.
Miscellaneous:
MISCELLANEOUS: This protein has no ortholog in rodents.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Vacuole membrane. Cytoplasmic vesicle membrane. Apical cell membrane; Multi-pass membrane protein.
Sequence:
MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSLR
The following text describes a protein:
Function:
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
Sequence:
MSTYLIGDIHGCLDELLALLAQVNFDPQQDTLWLTGDLVARGPASLDVLRYVRSLGPAVRMVLGNHDLHLLAVYAGISRNKPKDRITPLLDAPDADELINWLRRQPVLQVDDQLKLIMAHAGITPQWDIETAKMCAREVEAVLSSDSYPLFLDAMYGDMPNNWSPELTGLARLRFSTNALTRMRFCFPNGQLDMICKDTPENAPAPLKPWFDLPRLVDPEYSIIFGHWASLEGKGVPEGIYGLDTGCCWGGDLTLLRWDDKRYFTQRAFKAEAEINNNNGFAAGEAVQH
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAAILPDTHLVCYLCTSLKDSVVLRCLHCLCKNCLQSYWELNKSLECPVCLKETRCSVLLHHLSISRFASEGEFSQDSNFKPLHVGNLESEMQLEETTISQVMSTIPRIKTEEDMTTIVQMLMETKYEPVETSIDDLIYTPTIEDISSVKREPSNEVSNEEIHRDLMIHDTVPTSSSVLTEPNDSGEPPHLSTTTTCRSLRSNLCLKCGKSFERKSDLRAHEKVHSLQKPHQCSTCGKSYVDRHELSMHERLHTGEKLFDCSYCKKKFVRESALKYHLRSHTGEKPFSCSQCGKSFSRRSTLNTHLRLHMGPLPHQCDHCGKLFNTAAAMRAHRATHTGERPFPCPQCDKKFIFKAELEVHLDGHAGNKPFKCSVCGKGFLRKQECNVHQTIHQDKRSFHCTYCDNSFKRLSHLTSHLKIHYPESPHKCTYCEKSFKHPNSLKLHERLHTGEKPYSCEHCGKRFPSSGDRTRHLAVHSEVKSYKCPKCDRRFRFKNSLQSHQVMHTGERPFHCKKCDRDFARLANLKAHSVVHTEERSYSCSQCGQAFKCSSTLKSHMIIHSSKTLLDCTTCGKTFTRHDTLKRHQDIHAGIKVYKCTDCGKCLSSASCLKLHMEGHSGNKKMYYCDECEKSFSSMSYLQKHRQMAHSDEKPFVCFECGESFNSDGKLVTHQLQHSGRMDHACTECGKKFARKETLRRHVKAHSEERPYQCSDCGKGFKRSDQLKQHKLIHSERV
The following text describes a protein:
Function:
May play a role in proteolysis leading to mobilization of nitrogen during senescence and starvation.
Sequence:
MLTDDVLPDNVLPETKDWRKDGIVSPVKDQGQDCGSCWSFSATGALEAAYHQKHGKGISLSEQQLVDCATDFNNHGCKGGLPSQAFEYIKYNGGLETEQAYPYTARNGTCKFSARRVAVRVVDSVNISKGAEDELKHAVGMVRPVSVAFQVVKGFQFYHKNSGVYTSDTCGSTSMDVNHAILAVGYGVKNGVPYWLIKNSWGESWGDKGYGKVKMGKNMCGIATCASYPIVA
The following text describes a protein:
Function:
May regulate cdk7 involved in transcription regulation and cell cycle progression.
Subcellular Localization:
Nucleus.
Sequence:
MSYNESSQIKYWMFNNEGLKKLREQCNNQHKQVILEKTPSSEPNILSPDDELSLIHYYETKTLEIAMALNLPDKVSAPAIIYIKRFYLKNSIMQYGAKLVMLSCLFIACKTEDNHLDIDYYSNITKASPSDITNLEIIILESLNFNLIVYHPFRPMYGYILDINDNSAIYNNTNGVSPIKFDTLWETCKKSIQKSLFSDCCFEFHPQIIALACLNLNWDGFNMYCINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLLL
The following text describes a protein:
Function:
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGRWAAGSPRERTGRFPSRSSCLGPGGSPRRCSFSRGRLLYVPWEVGGHGGLGPTPLQPSDQRSPFKARVFGGRKGNWETVPGTRGDIFPLLPPPFPPHPSPQPSSNSSGWVRGWTRGRLVGREEEEGEGGRVEDGVGAGGERWRREEKRMERGGEGRMGRREKRMGRRQGKGLTSTQSSPPPPLPAAPDPPVSRRPPHHHRKSKAKPNGKKPAAEERKLYLEPEYTKSRITDFEFKELVVLPREIDLNEWLASNTTTFFHHVNLQYSTISEFCTGETCQTMAVCNTQHYWYDERGKKVKCTAPQYVDFVMSSVQKLVTDEDIFPTKYGKEFPLSFESLVKKICKYLFHVLAHIYSSHFKETLALELHGHLNTLYIHFILFVREFNLVDCKETTVMGDLTEVLCGSGAGAGAQNHVKER
The following text describes a protein:
Function:
Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis.
Miscellaneous:
MISCELLANEOUS: Potency of neurotransmitter agonists in stimulating cAMP production and the lack of stimulation by other transmitters and metabolites suggests this is a D1-like receptor. Low homology to vertebrate D1 receptors suggests this may be a progenitor of the D1 receptor subfamily.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYTPHPFGFLIILVPMTNAMRAIAAIAAGVGSVAATVATSTTSSISSSTTIINTSSATTIGGNHTSGSTGFSTNSTLLDADHLPLQLTTAKVDLDIEIDIQLLTNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSGRSSAELEQVSAI
The following text describes a protein:
Function:
Transcription factor that plays a central role in ovule patterning by regulating cell proliferation of the maternal integuments and differentiation of the maegaspore mother cell (MCC). Involved in AGAMOUS (AG) repression in leaves.
Subcellular Localization:
Nucleus.
Sequence:
MGYISNNNLINYLPLSTTQPPLLLTHCDINGNDHHQLITASSGEHDIDERKNNIPAAATLRWNPTPEQITTLEELYRSGTRTPTTEQIQQIASKLRKYGRIEGKNVFYWFQNHKARERLKRRRREGGAIIKPHKDVKDSSSGGHRVDQTKLCPSFPHTNRPQPQHELDPASYNKDNNANNEDHGTTEESDQRASEVGKYATWRNLVTWSITQQPEEINIDENVNGEEEETRDNRTLNLFPVREYQEKTGRLIEKTKACNYCYYYEFMPLKN