lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha. Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit. Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha. Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (By similarity).
Subcellular Localization:
Chromosome. Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase.
Sequence:
MDLPGDSSTPGRQRLCRQPHAGALWGAKSPKRPKLQPLGAPSPLEKASRRVLAVVLEDVMAARMVPLEPQEESSTPRHHSNHRDSVRSQPPASPPRQAMWSPQARPPDPLHLCREPLSRIRRPPSTPRRQSRTTPGPDEGPSQKVDQVHQPTLVVMLQDIASSRPRAEGFADEAPNFIIPARRAEPKVMVHQPKPPSRDLPAPSRPSALSANPLASPPPAPDPVLEPPSTPPPSSLLRPRLSPWGLAPLFHSVRSKLESFADIFLTPNKAPRPPPPSPPMKLELKIAISEAGQPGASEGTVTVSPRPPIRQWRAQDQNPSATLTKPSLGRSHSCPDLGPPGPDPCSWPPVPAPSSRPRPRRHTVGGGEMAKAPPPPRPCLRKEVFPLGGVGASPPLVTSCSSTASTSSFSEPAEPRLSSTKRKEPRAPEDQVLPDSETKTIGKVSRFRIRRTPARSQINLTPMGLPRPVRLNKKEFSLEEIYTNKNYQSPTTRRTFETIFEEPRERNGTLIFTSSRKLRRTVEFRDSSLPRSRRPSRGARATAGRTLPPSLAPSPDVEPLLQQRLQELDASLLEEEEEGDQDQPHRT
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Sequence:
MTQAVLGIIGGSGIYDLPGLEGAHEEVIKSPWGEPSAPLRRGTIAGLPIVFLPRHDKGHRLSPSDINYRANIDVLKRAGVTDLISLSACGSFKEEMPPGTFVLVDQFVDRTHKRESSFFGRGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAIARGGTYVCMEGPQFSTYAESMTYKTSGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLTSNADKAKALVARLAKDFPREHEPCPIGSDRALDTALITAPEARDPELLKKLDAVAGRVLRG
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAASSPAATATTTPPIAGTAIHRGPGAARLLSGSLSRRSPPASTAQAVSSSAAPKPRGLLLPCRAAEGAAPARAEAPLKVMISGAPASGKGTQCRMIVEKYGLVHISTGDLLRAEVSSGTDIGKKAKEYMDSGMLVPDQVVTDMVVSRLSQPDVRERGWLLDGYPRSYAQAQSLESMKIRPDIFILLEVPDDNLIDRCVGRRLDPVTGKIYHVKNFPPENEEISARLTTRSDDTFEKVKSRLETYKQNSEAVIPTYSDLLNQIDGNRPVEVIFREIESMLQKICTNASEKKLAKTNGKPPDTTASKKEWRGIPTRLNNIPHSREIRKYFYDDVIQATKRAIEDKKTRLQIDINIPELNPEMDVYRIGTLMELVRDLSLTFADDGKRVKVCVQGSMGQGAFAGIPLQLAGTRKILEFMDWGDYGAMGAFINIGAVGASEVDKEDDMFVLIAPQNAVGNCIIDDMRAMTDAAGDRPVILVNPRLKDMPASSGVMQTMGRDVRLQYAASFETCYSFRLLFYAGTFYPIMGALRMAYPNKYEIFRRVDEPNGEKYDLLAEFTGNPTADDITNAFVGPKKKKENAPSGFWGFLSGIL
The following text describes a protein:
Function:
Acts as a tumor suppressor. Acts as a tumor suppressor for colorectal cancer cell proliferation by targeting KEAP1/USP17/ELK1/CDK6 axis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MGCRCCKMIQSYLFDPVQVPSPGFVNEVNNCKLEEDDTVRLKGTQNSEVEVPRNALHDGSLSNSESRGSTTGLPHQGPLPQEDSEERPCVEKQGIVNGISPTATLQSVRSSRLHQVDNSSWASSPWVATIDSAHLAQPFLEGEDYRKQSCLLPTLEGTQMVGHGDCRAPAEALAVADHIPYIPAPDYPQLWSPTVDNADPEEKDCLFENHSEVEPLPGIQPRVSQLGLNVPFSLQRSWDSLNEAGTTEVLSDYFKEEGPTHPTPAADSGSEREDPHTYNGDREGVVVDEDAEVAEALAALEAATAGEDADDAD
The following text describes a protein:
Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEVTAEKRESEFAAHKESEDRERVAVDLKAGLHPLKHKFAFWYTRRTPGVRTQTSYEDNIKKIVDFSTVEGFWVCYCHLARPSTLPSPTDLHLFKEGIRPLWEDAANCNGGKWIIRFKKAVSGRFWEDLVLALVGDQLDYGDNICGAVLSIRFNEDILSVWNRNASDQQAVMALRDAIKRHLKLPNGYVMEYKAHDASLRDNSSYRNTWIRG
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTTLIEQLITKMGLREEPNVLEKTTELVRLLELRSTNVPLQINEYGKIVLCADLASCMIGIAFDKEQALKLSGLRKSQYLNNKRMFEKLLDLNKLASVNDICVQLGLNEVARKAEELMTLFKGVAATEDMGTDTSHPQYATMAVFQACRLLKKKVSKSKLMPFSNLRPSQFQLLEQQWERMIAKHHKESKVPSSTDMEGKLKENQNENIKGHEAKKAHKPPPEDYEIWKARMLAKAQAKLKELEASQSHMDSQLLEA
The following text describes a protein:
Function:
Probable transcription factor that may be involved in stress responses.
Subcellular Localization:
Nucleus.
Sequence:
MMMGQDEVGSDQTQIIKGKRTKRQRSSSTFVVTAATTVTSTSSSAGGSGGERAVSDEYNSAVSSPVTTDCTQEEEDMAICLIMLARGTVLPSPDLKNSRKIHQKISSENSSFYVYECKTCNRTFSSFQALGGHRASHKKPRTSTEEKTRLPLTQPKSSASEEGQNSHFKVSGSALASQASNIINKANKVHECSICGSEFTSGQALGGHMRRHRTAVTTISPVAATAEVSRNSTEEEIEINIGRSMEQQRKYLPLDLNLPAPEDDLRESKFQGIVFSATPALIDCHY
The following text describes a protein:
Function:
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Sequence:
MAAVSTVSSCKWRLSCRAFLYFNGSRSASLTQARHHAHCQMIHGSSLNHSLQVYERHRGITRLNFLQRYSGASQSCIARHPTALQTLHHHCRPSCNASADSMNHHHNAFAANPSQALHCHSFTRCHGPQQLDLKAMACACRTTQSSNFDLLHGRRWLHCTGSHQLDHKHSRPGLIEPKRHLSLSPAVIVNAAPSKMQPYLRLIRLDKPIGTWLLYLPCTWSIAMAASPGHFPDVYMLGIFGLGALLMRGAGCTINDMWDKDFDKSVERTKVRPLAAGEITQFQALCFLACQLSASLAILLSFNWYSVALGASSMLLVVSYPLMKRITYWPQAVLGMAFNWGAILGWAAIHGSCDWSVVLPLYVAGISWTLVYDTIYGHQDKNDDMLLGLKSTSIFMGDRTKQWLSGFGSLMIGGLVLSGYNAEQTIPYYLAISLAGAQLANQIWTVDINKPEDCWNKFHSNKRLGLIIFAGIVAGTLAKALPDSDEMKDYPEKDISRKG
The following text describes a protein:
Function:
Component of the NatC N-terminal acetyltransferase, which associates with the ribosome to acetylate nascent protein chains in a cotranslational manner. NatC acetylates protein N-termini starting with methionine, followed by a hydrophobic or amphipathic amino acid, with amino acids at positions 3 and 4 also contributing to NatC recognition. The first 4 amino acids of cognate substrates are recognized at the Naa30/MAK3-Naa35/MAK10 interface. NatC-dependent acetylation targets various substrate proteins to specific subcellular sites, including isoform 2 of tRNA-specific methyltransferase Trm1 to the inner nuclear membrane. Catalyzes the acetylation of the N-terminal Met of ARF-like GTPase ARL3, which is required for its Golgi localization via interaction with the Golgi-localized integral membrane protein SYS1, which may serve as a receptor for acetylated ARL3. Catalyzes the acetylation of the N-terminal Met of L-A virus Gag protein. MAK31 is necessary for the structural stability of L-A double-stranded RNA-containing particles. Necessary for growth at 37 degrees Celsius as well as for maintenance of the killer plasmid.
Miscellaneous:
MISCELLANEOUS: Present with 2140 molecules/cell in log phase SD medium.
Sequence:
MDILKLSDFIGNTLIVSLTEDRILVGSLVAVDAQMNLLLDHVEERMGSSSRMMGLVSVPRRSVKTIMIDKPVLQELTANKVELMANIV
The following text describes a protein:
Function:
Exhibits ATPase activity in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MSGSSLACNRDVSLTIGDVTVPVPANVSHPERVTWVLPGDTTNSGAFHIGEDAADELSLDVGDMFFHLGDNATRQYLRWICQKELLKQDMCLTGEPGPALRWLVLLYSRLTRREVQCVSLNRDTNEGDLGQRREIRNGTLSYEDQSVVIAAREGQLLLLEGLERVERNVLPVINNLLENREMHLENGMVLIHPERYDKIFNEALCEELKGGRQDANVEGGIGNQIPQAVHAKLQRMGFIRVSESFRVIGITAPVPPYDGTPLDPPLRSRFQCLYVDLPPPTLAATNVTNMAPGGRARGVFESLLKLRASIEEMNARTRGFTSGGTQGRDSAVGGCVSSLCGLQTIGSYEVAQVFRQFMLFPDVPVSELLLRSFPWTLYAQQTGSGSGTYEESMRRLRDYERVLAACDIGTPLSNHICHHSDVSVRDSGKPTDHCTHEDCAVRSSKHYNDVVFIDNVRVAKSKVLAVLQHPVVVGDACVDGMKGKYQLPLYLGEFALKSSRGGPSSPSSGRKWRTVDVKVYCSSSSTVFTPGHVHVLQSMLQLHIAGRHILLLGSSGSGKTTLLHEFARLLGYQTETMYLYADMTIKDLFQRRATDSVSGDTVWQNSALVDAALNGRMAVLDGIDKMPLGMLSSLQQLLIDGSTSLCDGSVLKSFKEYGIIKEKLRATEEEMKARRIFPIHPSFRVVGTARFPALNSNGTGNKVWQNQWRVTHDVTELFGVVQMPSCSQSLFRAILLRVAELELQFCGNEKVDGIRASVGPEGGISSGLKRDVDTLLRLRDELERLQVTEPKTPQLSLRQLLNLTRFRVRYPDDFNISVESTLLLPLLSSLVAEKVRQVMQICGFTCTSGLAERKQDPLRSSSVSKSSMGETLNCHSLKEFLLPCDPTIPNAGAGKAEGIEVSRVFGLGDKPILRINRNYGAKEKAMVPHVPHFHPNPVHESVIVWLAKQYAVGNNILLIGNQGVGKNKVVDAFLARVGTPREYIQLHRDTTVGSLTINPTVENGRVVWADSPLVRAVQQGHCLVVDEIDKAPVEVVQVLKGLIEDHEMRLRDGRQILGPRAHVVRFSISSSDYGSSEQKNIINMHPDFRVIVLANPPGFPFHGNDFYRECGDLFAPSVMLNADAHSQLQVLRAYGVNIPDALLMSLIECFQRLQTDFEEGNITYPFSLRELIAVVRHMSMFPGDGVYAALNNIFNFDVFDENTLRLVRNVLRLHLDPLVQFGGMQKLLPLRTSRAVPLRPSPSLIHMSAKSPAFLPLKLGEVVMSLPVRRLTDLECGGAINWKSAPVWCESYNATDFAADVSANGGLVGFSEWTTATRLPFLQQGDRVIRVAVEAPECVVGESKSVAVLFTRQHVLREEMNGSSSPLATTEIFLAIASLPSVASIAATAVGRKRLAAGQVQLLNLTDLLPLNSLPSSSLRFLGTEASGILASQALKESSHGAFGTSPSFVEVACASSGSILLADASALGLCSTSTALPRGQVRGQGDAAGDKLLGSVLVVHLMPPSSDVALTRHTVCPGCNLVAMTRPREPELYVWSNGHRVGVTLPAEDIRGIHFFANNYASVHLSKSESTFCGVMKLSLMSDGVATASLCLLPNEINGVVVGLTGTKEPTPTEAAMGPVTPEELQGAIIVAGAGSDSEKEGVLYTMVESYSSRSQSWSMRTFANPSISPAVCSDLNHHGTIGIDRVHKQLVVASGSDGVDTCGSLFAVDYHHHTVRHFAPTPTTSSRSSSVKPSYPCFSLDEVAGNILRYDEVNRQLLIGDLVAERVECRHRQLSALLQGSVKQVGAAAATPQGKLSMSYCTSRYAASNNLKHGREDNEEHHGGNTYAGGTGGTDTAGLGGLVGPYRLDKGWPVHQVSPEAKQQVPQHIIEEARRMGRVALQERLREIGMTSTEYERYGALQGRVRAPVAILRSMLSGLKAAEGERVWLRGQTDGVWDDSKIVEGIVGERNIYKRRADYADASPFQLKRKKRLLFVLDVSASMYRFEGMDQRLTKLLESTVMVMEAFTGYEEKIDYAMVGHNGDSACIELVPFGKPPTNQKERAEVCQRMVAHAQYCWSGDNTVQAMRQSIELVTAEKGEAYLVFVISDANLSRYGIEPGELGEIMESNQEVQMFCIFIATLGEQALNLREKLPSGHGFECMDTQALPHILKQIFLSVNLL
The following text describes a protein:
Function:
3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).
Subcellular Localization:
Nucleus, nucleoplasm. Mitochondrion matrix. Nucleus, nucleolus.
Sequence:
MGHRFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVGGEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKMYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQRFQVDPSGEIVELAKGACPWKEHLYHLESGLSPPVAIFFVIYTDQAGQWRIQCVPKEPHSFQSRLPLPEPWRGLRDEALDQVSGIPGCIFVHASGFIGGHRTREGALSMARATLAQRSYLPQIS
The following text describes a protein:
Function:
The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endomembrane system; Peripheral membrane protein.
Sequence:
MSLVQEDRKMDLKRTYEAQLALICKQIPDLWGDKQGKKDVEPAQSQLVVCESQFVVVRQIGELRLMLSGNQEYDELILDEIMTVLHAVLTTQLDKKFTEASLLANYAKVVVALDEMVQQGHLENADEASIDQMTKLKPYPSK
The following text describes a protein:
Function:
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The homeodomain is essential for interaction with OLIG2.
Sequence:
MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEESEGPEPAKRAGPLGQGALDAVHSLPLKSPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRCVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
The following text describes a protein:
Function:
Multifunctional phosphatidylinositol 3-kinase involved in acidification of vacuoles, pH-dependent cell growth, and autophagocytosis. Plays an important role in protein transport and virulence. Component of the autophagy-specific VPS34 PI3-kinase complex I essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (By similarity). Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (By similarity). This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes) (By similarity). Finally, it might also be involved in ethanol tolerance and cell wall integrity (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Sequence:
MATLSQPQSALPKTKIATTFGLSKDLKSPISVKVCYLECTRNNVSLVPLSTKFEDPTVFKKLSQIYKNSDLFVEIRVYDGKNNNLISTPVRTSYKAFNNKGRTWNQQLKLNIDYNQISIDAYLKFSICEIIDTKPSVFGVSYLSLFSHDSSTLRSGSHKIPVFMEDDPQYSKNIQYGTLIGLTDLEKRLIDYENGKYPRLNWLDKMVLPKVDATFLKTNNKDHDYYLYIELPQFEFPIVYSDIIYQIPTIEPITETTSKIPPDDTLNSNIIINSIDIPMATSHDPSIMKVYDPDFHITANNHLNPNATTFDPVELKYRKLERNIDNNTILDKELKPTPQLRDELLRIMIKPSNAELTDNEKNLIWKFRYYFSKNNSGNDPSNKSVKSFLPKFLRSINWENDYELDHTFKEIIPFYWNVDKLQIGDALELLGDYFNPYTLGKPTYQDDSMTSKSSKMKSDEKRFIKIYNNVCFLRKLAVERLKLANSEELLLYLLQLVQALKYEALIYEKSPPFCERSDQIEDNASSTLKSPLADFLIERAVENEKLGNFFYWYVKVENEDQLNNPHIDGPIKIYMDILNRYIELLKAHCHENRLPYYKHLKHQIWFIKKLTSLVELLRASFKKNEATAKKVEYLREYLANSGNELLKFPEPFPLPLDPSVMICGCYPEESSVFKSSLAPLKITLKTIEKKKHGHATSQLFGKRSRYGKYPLMFKIGDDLRQDQLVIQIIDLMDQLLKNENLDLKLTPYKILATSPISGLIQFVPNETLDSILSKTYPTSVTYSGGGETSDVPPSVSNNGILNYLRLHSQEQQSEEPISKSILSTNTSQSNTEIPVLPRQPKPTITSDLGVSPILMDNYVKSCAGYCVITYILGVGDRHLDNLLLSPNGKFWHADFGYILGRDPKPFPPLMKLPIQVIDGMGGLHHENYNVFKSYCFITYTTLRKNSNLILNLFQLMLDANIPDIQFDPSRVIEKVQEKFCLQMTEEEAILHFQNLINDSVNAFLPVVIDRLHSLAQYWRA
The following text describes a protein:
Function:
Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MILARDDKWTLGSIALIFVLLIGFALLFLLERFRVKEKSRTFKDCVNVYQCPSKGERVYLALRHWFIFLATHKAQMTLILSPLVMLVTIPFTGKETKNSIASYDWNLTGVAARLGYLSCGLFFVSYFFSLKNNPFCLMLFSSHEKMNYLHRWLSVYAVLISVLHGILFMIFSAQSYKPLLYDKISIYGYFITVVLFLMTVASLPSVRRKFFEWFFVLHHTCSVLIIFLIWLHHPRTIVYMKACIIIYAFDRGCRLFRSIWNRSNFRIYLLNEDMIYMVGRKPKRSFFALPWAAGSHVYINIPSLSYWQVHPFTLASAPFDDFIELFVAVHSGFTERLANRLYSMPHEYPNFSLAPGTPESLSNTYRELNSFKSYAVEIENTAQGHTYEPEDLYLETTVFMDGPYGTTSNVFKEYSYVLLIAGGVGFSYTLPILRDLILKECNVTSITFIWSCRSLSLLKVASKSLNSLLHQSNVRLKIINHFTGSISCKESSEFSNQTTENSEMEFFDDRPDLDMYIQKFFDYVGYQTAALAACGSQSFLKRIKNSVNKSISSTTDIYQHYEEL
The following text describes a protein:
Function:
Essential for spermiogenesis and fertilization. May be required for manchette assembly in elongating spermatids (By similarity).
Sequence:
MTLQGRADLSGNQGNAAGRLATVHEPVVTQWAVHPPAPAHPSLLDKMEKAPPQPQHEGLKSKEHLPQQPAEGKTASRRVPRLRAVVESQAFKNILVDEMDMMHARAATLIQANWRGYWLRQKLISQMMAAKAIQEAWRRFNKRHILHSSKSLVKKTRAEEGDIPYHAPQQVRFQHPEENRLLSPPIMVNKETQFPSCDNLVLCRPQSSPLLQPPAAQGTPEPCVQGPHAARVRGLAFLPHQTVTIRFPCPVSLDAKCQPCLLTRTIRSTCLVHIEGDSVKTKRVSARTNKARAPETPLSRRYDQAVTRPSRAQTQGPVKAETPKAPFQICPGPMITKTLLQTYPVVSVTLPQTYPASTMTTTPPKTSPVPKVTIIKTPAQMYPGPTVTKTAPHTCPMPTMTKIQVHPTASRTGTPRQTCPATITAKNRPQVSLLASIMKSLPQVCPGPAMAKTPPQMHPVTTPAKNPLQTCLSATMSKTSSQRSPVGVTKPSPQTRLPAMITKTPAQLRSVATILKTLCLASPTVANVKAPPQVAVAAGTPNTSGSIHENPPKAKATVNVKQAAKVVKASSPSYLAEGKIRCLAQPHPGTGVPRAAAELPLEAEKIKTGTQKQAKTDMAFKTSVAVEMAGAPSWTKVAEEGDKPPHVYVPVDMAVTLPRGQLAAPLTNASSQRHPPCLSQRPLAAPLTKASSQGHLPTELTKTPSLAHLDTCLSKMHSQTHLATGAVKVQSQAPLATCLTKTQSRGQPITDITTCLIPAHQAADLSSNTHSQVLLTGSKVSNHACQRLGGLSAPPWAKPEDRQTQPQPHGHVPGKTTQGGPCPAACEVQGMLVPPMAPTGHSTCNVESWGDNGATRAQPSMPGQAVPCQEDTGPADAGVVGGQSWNRAWEPARGAASWDTWRNKAVVPPRRSGEPMVSMQAAEEIRILAVITIQAGVRGYLARRRIRLWHRGAMVIQATWRGYRVRRNLAHLCRATTTIQSAWRGYSTRRDQARHWQMLHPVTWVELGSRAGVMSDRSWFQDGRARTVSDHRCFQSCQAHACSVCHSLSSRIGSPPSVVMLVGSSPRTCHTCGRTQPTRVVQGMGQGTEGPGAVSWASAYQLAALSPRQPHRQDKAATAIQSAWRGFKIRQQMRQQQMAAKIVQATWRGHHTRSCLKNTEALLGPADPSASSRHMHWPGI
The following text describes a protein:
Function:
Involved in nuclear migration and anchoring in hypodermal precursor cells. Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Its role in nuclear migration may be in association with lamin, lmn-1. Regulates nuclear migrations in one-cell embryos, controlling the posterior migration of the male pronucleus following fertilization. Not required for centrosome attachment to the nucleus. Plays a role in the maintenance of the nuclear envelope architecture in body wall muscle cells. May be involved in DNA damage repair through an association with zyg-12. Potentially has roles in homologous recombination, double strand break repair and meiotic recombination. Specifically, may in part inhibit non-homologous end joining repair, most likely through recruiting fan-1 to the nucleoplasm, to facilitate the repair of DNA cross-links.
Subcellular Localization:
Nucleus inner membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Note=Associated with nuclei during interphase, prophase, prometaphase, metaphase and early anaphase. Released from nuclear membrane in the same time that the nuclear envelope disassembly, during late anaphase, and begins to reaccumulate in early telophase. Localization at the nuclear envelope depends on lmn-1. Co-localizes with unc-83 at the nuclear envelope, but its localization at the nuclear envelope does not depend on unc-83.
Domain:
The SUN domain probably plays a role in the nuclear anchoring and/or migration. Required for the localization of unc-83 and anc-1 at the nuclear membrane.
Sequence:
MAPATEADNNFDTHEWKSEFASTRSGRNSPNIFAKVRRKLLLTPPVRNARSPRLTEEELDALTGDLPYATNYTYAYSKIYDPSLPDHWEVPNLGGTTSGSLSEQEHWSAASLSRQLLYILRFPVYLVLHVITYILEAFYHVIKITSFTIWDYLLYLVKLAKTRYYAYQDHRRRTALIRNRQEPFSTKAARSIRRFFEILVYVVLTPYRMLTRSNNGVEQYQYRSIKDQLENERASRMTTRSQTLERSRKFDGLSKSPARRAAPAFVKTSTITRITAKVFSSSPFGEGTSENITPTVVTTRTVKQRSVTPRFRQTRATREAITRALDTPELEIDTPLSTYGLRSRGLSHLNTPEPTFDIGHAAATSTPLFPQETYNYQYEEATGNKIKTAFTWLGYLILFPFFAARHVWYTFYDYGKSAYMKLTNYQQAPMETIHVRDINEPAPSSSDVHDAVGVSWRIRIADFLSSFVATIVEAHQVVFAMFKGGIVETVSYFGGLFAGLTDKKSSKFSWCQILGLLLALLFAIFLLGFLTSDNTAIRVKEITKDKNASKKSEGSLPAVPIWISAANHVKHYTWMVKEFVVDIAFDTYNYGKSTIGRLGTTPRYAWDLIASGCGAVGNGLKSVLSSSFRFIDFCAGKLFYYGSDGFLSANKSIGTFFNGCYETLYNGCTAIVGHTKSFIYNASNAVYNFFSTIFAGLLNFSTSSQNSILSLLKSFGTGITNIFYNFIYAPIAGVFNFAGDNYMYFFNEVAAVFGKVYNSVVSVLKTVINWILFLIAYPFSLCTRAWIRISQYAPEDVVQVIPIPQAITPTPDVERIVEEPLRKVTDVEDEELVIIPAPAPKPIPVPAPTPAPVIIHQTNVVETVDKDAIIKEVTEKLRAELSAQFQQELSAKFEQNYNTIIEQLKMENTNIQYDKNHLEAIIRQMIYEYDTDKTGKVDYALESSGGAVVSTRCSETYKSYTRLEKFWDIPIYYFHYSPRVVIQRNSKSLFPGECWCFKESRGYIAVELSHFIDVSSISYEHIGSEVAPEGNRSSAPKGVLVWAYKQIDDLNSRVLIGDYTYDLDGPPLQFFLAKHKPDFPVKFVELEVTSNYGAPFTCLYRLRVHGKVVQV
The following text describes a protein:
Function:
Acts as an actin bundling protein.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDETEWIHRHPKAEDLRVGLISWAGTYLTFEACKNTVTATAKSLGRRQTWEILVSNEHETQAVVRLKSVQGLYLLCECDGTVCYGRPRTSHHGCFLLRFHRNSKWTLQCLISGRYLESNGKDVFCTSRVLSAYHMWTPRPALHVHVILYSPIHRCYARADPTMGRIWVDAAVPCLEECGFLLHFRDGCYHLETSTHHFLSRVDRLFSQPSSQTAFHMQVRPGGLVALCDGEGGMLYPQGTHLLLGMGCNPVRGEEWFILQHCPTWVSLRSKTGRFISVIYDGEVRAASERLNPMSLFQFECDSESPTVQLRSANGYYLSQRRHRAVMADGHPLESDTFFQMHWNCGRIILQSCRGRFLGIAPNSLLMANAILPGPNEEFGILFANRSFLVLRGRYGYVGSSSGHDLIQCNQDQPDRIHLLPCQPGIYHFQAQGGSFWSITSFGTFRPWGKFALNFCIELHGSNLLTVLAPNGFYMRADQSGTLLADSEDITRECIWEF
The following text describes a protein:
Function:
Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
Sequence:
MNVILSATLLFLLINGPFYVECVLPLVINTWPFTNATEKAWSVINGGQSTLDAVEEGCTVCEVQQCDGTVGYGGSPDEFGETTLDAMIMDGDTHTVGSVGGLRRIKSAISVARAVMMYTTETLLVGESATKFAIEMGFQQENLTTNRSRSIWEEWQKANCQPNYRQNVSPDPSGSCGPYTPVNANALKTSTRERYNSDINKNNHDTIGMIVIDSNGRIAGGTSTNGANHKVPGRVGDSPITGSGAYVDRDVGGAAGTGDGDVMMRFLPSYQVVENLRNGMSPDKACQSALQRIIKYHPDFSGALIAATIDGQYGAACHGFSSFHYSVRNPSMSSVQVLEVPCSSASNNHL
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Sequence:
MVNKQYSATDLEAFMKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRNGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQVAMHHQHNNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHGVKRRLWTQEALKQKRAQDKQRIKAYRDQTARVLRLRDAGAYSMEALAETTSLLQMNGEFNAVWNYRRDIIAALREQLDGGFWEAELKLTMAHLRESPKVYWIWNHRQWCLQHHAEQGAAVWKRELALVGKMLELDPRNFHGWHYRRVVVRELERRSGASLDSAELSFTTEKINENISNFSAWYQRAQLIPRMIASGKIADTSRFAEEEASYIINAMYTDAEDQSVWMYLKWFAEASCIRDDMPLQDYDCMLTKFRENIMAINQDELEFSGRENIWCLKMLVFLGSIAPTQQESPAQRRHHLERLIELDSMRRNRYIHMLENA
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Subcellular Localization:
Cytoplasm.
Sequence:
MQAPVLVLKDSLKRESGTKVHHANIQASKAVADIIRTTLGPRSMLKMLLDAAGGIVVTNDGNAILRELDLAHPAAKSMIELSRTQDEEVGDGTTSVIVLAGEMLHVAEAFIDKSYHPTVICRAYIKALEDAIAVLDKIAMSIDVNDRATLLGLVKSCIGTKFTSQFGDLIADLAIDATTTVGVDLGQGLXXDIKKYIKVEKVPGGQLEDSKVLKGVMFNKDVVAPGKMRRKIVNPRIILLDCPLEYKKGENQTNAELVKEEDWAVLLKMEEEYIQNMCMQILTFKPDLVITEKGLSDLACHYLSRAGVGAIRRLRKTDNNRIAKACGAVIVNRPEELQESDVGTGAGLFEVKKIGDEFFSFIVDCKDPKACTVLLRGASKDLLNEVERNLQDAMSVARNILKNPKLLPGGGATELTVSATLKQKSSSVEGIEKWPYEAAALAFEAIPRTLAQNCGVNVIRTMTALQGKHANGDNAWVGIDGNTGEITDMKERKIWDAYNVKAQTFKTAIEAACMLLRIDDIVSGIKKKQAPGAGPSKPKIETEADADGEQILPD