lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Enhances binding of IGF2BP1 to N6-methyladenosine (m6A)-containing mRNAs, thereby contributing to increased mRNA stability. Also increases the interaction of IGF2BP1 with RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1, and increases the interaction of RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1 with m6A-containing mRNAs. Contributes to MYC stability by enhancing binding of IGF2BP1 to m6A-containing MYC mRNAs and increasing recruitment of RNA stabilizing proteins to m6A-containing MYC mRNAs.
Miscellaneous:
MISCELLANEOUS: Promotes colon cancer cell growth, colony formation, migration and invasion through enhanced stability of MYC. Expressed in colorectal, breast, ovarian and nasopharyngeal cancer cells. Higher levels are found in colon cancer cells than in adjacent nontumor tissue.
Sequence:
MIQQEEIRKLEEEKKQLEGEIIDFYKMKAASEALQTQLSTDTKKDKHPDPYEFLLLRKIKHPGFNEELSPC
The following text describes a protein:
Function:
Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment.
Sequence:
GNRRQTRRSRNSARSALTPPLREARPTERPKPGVLLRTRRTLAGSSSLLSRDANTGLSRDATAGLSRGSLGEFRPRGRGAARRGSALGSVAVAIVGFSRQDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWQAYVDTSLLGTGKIDRAAIVSRAGDSVWAASAGFNLSPQEIQGLAAGFQDPPSMFGTGIILAGQKYITIRAEGRSIYGKLQKEGIICVATKLCILVSHYPETTLPGEAAKITEALADYLVGVGY
The following text describes a protein:
Function:
Stimulates salicylic acid signaling in host plant roots.
Subcellular Localization:
Secreted.
Sequence:
MQITKTLVATLFAASTAFAAPTPADKSMMAAVPEWTITNLKRVCNAGNTSCTWTFGVDTHLATATSCTYVVKANANASQASGGPVTCGPYTITSSWSGQFGPNNGFTTFAVTDFSKKLIVWPAYTDVQVQAGKVVSPNQSYAPANLP
The following text describes a protein:
Function:
Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism.
Sequence:
MAGVLRRAIYPAARHAITEISRPIAFRASQAMTAHVGAGSGGRVGGWAVRSPPQDIPFAVKGLQHIAIAVPDLSVAAEHYRSVFGAQVSQPVDHVDLKVTKVFVQLPNVCIELLHPMGQDGPVAEFLKNNPNGGIHHVSFAVDNINSAACYIGEAGVGSIPTGNPNIGASYKSEMFLQPKDNMGVLIQLQQITNRSRARV
The following text describes a protein:
Function:
Exerts antifungal activity through its carbohydrate-binding specificity.
Sequence:
MSISSKFQLRSSTSLLLLVALMVVMGMDGAAAAPNTNFVSSACNTQKIPSGNPFFTNLRAMLADLKQNTAFSGFDYKTSRAGSGGAPTAYGRAICKSSISQSDCSACLSNLVGRIWGICSNAIGARVQLTDCFIQYEQHSF
The following text describes a protein:
Function:
mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Plays an essential role in cytoplasmic stress granule formation (By similarity). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity). Binds directly and selectively to MYC and CCND2 mRNAs (By similarity). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity).
Subcellular Localization:
Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, cytosol. Cell projection, dendrite. Cell projection, lamellipodium. Note=Mediates formation and localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity). Associated with RNA granules. At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity).
Domain:
The C-terminal disordered region undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. CAPRIN1 molecules in the condensed phase are neutral. mRNA-binding promotes phase separation. Moderate concentrations of ATP enhance phase separation by reducing the electrostatic potential of CAPRIN1, thereby promoting intermolecular interactions. In contrast, high concentrations of ATP invert the electrostatic potential of CAPRIN1, so that CAPRIN1 molecules become negatively charged, lead to inhibition of phase separation.
Sequence:
MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDDVRTDLKQGLSGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKALKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPTVEDQVAEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFSSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQSDPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPQVHSESRLAQSNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPMDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPANEPETLKQQSQYQATYNQSFSSQPHQVEQTELQQDQLQTVVGTYHGSQDQPHQVPGNHQQPPQQNTGFPRSSQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRPSFSNTPNSGYSQSQFTAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN
The following text describes a protein:
Function:
Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage; Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content. May recruit CACTIN to the spliceosome; Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor. Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAETAALVWVRGPGFGCKAVRWGSAPCSVRDFIHRHCQDLGVPVDCFFVKCNGSLVNSSDTVQRGAVYSLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQRRLERLQRKLTEPRHCFSSPDYQQQCHEMAERLEDSVLKGMQAASSKMVSAEIGDSRKRPNTSGADGGARAGKKKCFWLGMEGLETVEGSSSESSDDDSEEAPGTSGTSCHVPKNGSDGAEMAAEFPSSSQGARVLSTDSTLPEKARTPASDFGNGVSEDSCPELGETSAKEDVERKMAAETEETQEEKESGSQGAIGKEAVGAGLNKEEETKERTDEGRAAQVSPGGERENVPMAELGRSQAGSTGVGLETVDLLAFSSVAEVESLGLERLKCELMALGLKCGGTLQERAARLFSVRGLAREQIDPALFAKPAKGKKR
The following text describes a protein:
Function:
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGKLIRMRPQARRLLRTKRLPWSRLLFLLGMLIISSTYQHLRGPRGLSSLWAAVSSHQHVKLASRDLPSEEMMMVSSNPPKPSSEMGGKMLVPQASVGSDEATLSMTVENIPDIPKRTAKMIPTTIKNNYSPTAAGTERRKEDTPTSSRTLTYYTSTSSRQIVKKYTPTPTGEMKSYSPTQVREKVKYTPSPRGRRVGTYASSTFMTMETSHAITLRTTVKDSDITTTYKILETNSPKRIMEETTPTTLKGMVDSTPTFLTHEVETNVLTSPRSIVEKNNLSPPRRVESNSSAHPWALVGKNNLKTPQGTVLTHTPATSEGQVTISTMTGSNPSETKAFTAAWSVRNPSPRTSVSAIETAPATVWRLAKKPYTAPSTSTTPTVRAKPTTQVHHCVVVKPTPAMPTTPSPSLTTALLPEELSPSPSVLPPILPDLPPKGEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKQIEAWVKEQLSRRPAAKVMALGDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDPLREVCLAEEKEEESLNQEARAQPQAKSESKPEDEEPAKLPAVTVTPAPAPDIKGDQKENPGGQEDVAEAESTGEMTGEEGETAGEGETEEKSGGETQPEGEGETGTQGKGEEREKENEAEGKGDNEGEGEGEIHAEDGEMEGIEGETESQELSAENHGEAKSDEKGVEDGGGSDGGDNEEEEEEEEEEEEEEEEEEEEEEEEEEGNEEPLSLHWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIVWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFCLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MEMLRARGSSTNGVVQVPNLLGKFFVTSNHFCHRDSEHGERREEAMKKDEDIELTLGLSLNGQFGTDPRSRKRKNFELARSSSIPEGFVFDGQRSGGDMRQTGVSDMFQLDRTRSLPVETEIEAKRKRAEKTKVQAEAKTFLSFNVPPLPTKEKGEKDGFLVPGPVSGRGKNGNTAKKKNQEVSGMEKARNILEDMPCVSTRDVGADGKRVEGFLYWYGGSKEEVKIVCVCHGSFLSPAEFVRHGGGTVSDGGGDVTSNPLRHIVVKLPSSSL
The following text describes a protein:
Function:
Extracellular metalloprotease that contributes to pathogenicity.
Subcellular Localization:
Secreted.
Sequence:
MKFLGVALASLGLVSAATVEKKVSYDDWKVYRINVGSNAAKVNDVVSKLDLQLWKGKPSSSSVVDVMVPPSQVKDFEASTSDVETRVMHDNLGLSITDEDSFNVYAAGAAPNATWFKSYHSIADHMQWISDLAAAYPKNSEVVTAGKSVQGRDIKGIHIWGSGGKGSQKGVVWHGTVHAREWITTMVVEYAAYQLLTSTDATVAGYKDKYDFYIFPIVNPDGFAYTQATDRMWRKNRQTTPTASCVGRDINRNWPNQWDLRGGASTSPCAEDYKGPSAGDGVETKVLKAQLDSIAAGKGIQLYMDIHSYSQLWMYPYGYTCSGAVPNAAKNKALTDGAIAAVKAVHGTVFTGGPICNTIYQVSGDSVDYAFEVAKAAFSMTVELRDTGNYGFVLPAAQILPSGEEMWAGLSYLLKNM
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MASTIMSQEVSWTDILEKHPALRWIKPIPEDWEIFPKHLCAFESFLYVAVGQEVRSLDCRLLKHKNEASHKNFYKKLFNPELDFMIEQICLSKNGRFLAVVGKSKIVILGLRSKLSEQNPLAESVSNFGESVNNFSNSEHQENGTNSLKLSEVTICSVAVINPSSQIVSVRFHPLGKSGRSLVVLTETSLLLYEAGNGVLMPDYEIPLKLTHQASNSFDADVDLHIPTAFCFSNVSQGWGVFTIYILTRGGDVFSVCPVMPANAMIPQDVLKQIRLILTKKEDDADAENHRRNVHWITKLLGEAALANDLSTSFVISEGSSELFDSSDYVSVRRPDDFSFIPSMQGPFLLQPAVADDELIEDYCDIYSFGMNPIDVLAIGGSEGRLDLLLLVSEVSGRWSKLNDHGLASMKLIVSQVHSLYLSNNNPYMVLQPDIQSPYSLIAYHANGLHVVDIESWARDLNLNFENSEFLNNEEENDEDELSNVLVSIPSRTSVLERLDTNPLNESTDAVVGCAQLYYPSLGKILISLTRNWQTTVFDDSDLATMGVNKESLSNEMDYSKSLGTSSLEQVDDLDEKLTYTPLYVSLLEKTPFTDPSIPSLVERTIVPAELQNEITVSSASLRFLGKVVARYRETLNLLDHGCSELHHRLKLQREEYERQQNHIYKLSDRISNFREKAWSTEHLEHLTSDMSMCEKRIDQVLQRVMDLRVPDLSDKEKQFIKEIGNYKEKVTGERGIEKRVETLKTLLQRTKPRDAQTTLVASSSDMRLAAIEQLQKLLAQQSLSIKELKTKTVSFQRLLQTS
The following text describes a protein:
Function:
Cytokine that is chemotactic for neutrophils.
Sequence:
MKPTAMALMCLLLAAVWIQDVDSKSMLTVSNSCCLNTLKKELPLKFIQCYRKMGSSCPDPPAVVFRLNKGRESCASTNKTWVQNHLKKVNPC
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MEIEEEKTKEKETKNYEEEEEGPSRNQENKKILVEEEHQQQQQITILSQTPESQHSTSSTSITPITPAEELVSCLPSASSSALKTSSNKPRKSKGKEKDGVPEHVQLISDLPQANHQALETFTQIDQNWYQNKSLGTTKQLEDAMVCDCTWTPGDDPSWACSEHSGCINYLTQIECLQDQCRCREKCQNQRFQKRLYAPIEIVLTPKKGFGMRLQADVPKDTFVYEYLGEVIGVKALHKRLKDYGQEGIKHFYFMELQKDQYIDATKKGGFGRFLNHSCNPNCYIGKWVVGRQLRMGIFTKRAVRGGEELTFNYNVDRYGHEAQECFCGEANCVGFLGGKTQTDLGAMDELYIDALGIVDDVENLNLKGSKTKKSKSMDIDYMPVMKPIPLKDVPKVAAAIRQSTSNRKILSKLLRRIMITTDQAVQKQLMRLHGFSLMSMILNEYLSDQEIVQTILEILLKWPLITKNKIVSTNIEETVMKLSDNPSEVIQTLAAEVIKMWVALEVSYRIPKDKKNGEVADGSKRKAEALLDQIFSKRLRDSNARKDIGGLKLVSEKAFIRPEAAKRIDPQTIKPENLTLPPDWAFERTAEGRPYYYHVAIRETQWTVPTAADVALMDRRLAEQIARQKAAAANVEDIVAKAKAEAEEIRKASEAQRASEEAEKARLKSLHSDRKDKLRPSRSSSSHHHNHHHHHHHHRKKNSKELPSGGSAKASSSDLKNEINNPAKDKKMLRLFSNVVVHTMSRYKDSLDHEQFKRRAKELTNILCEKERKSTHYQSEMYEEMSAAKEMKIKAFTKDWMVKLLTRKGIEIPPPSSTGTTTTTMASTSTGKKPMTMLEEGGHRRAEDRALGSSTADYQDYKAADDRPSEAREPDRHPIPSSSSNPSSCQSDPDSRPHPRTQNRSRHRSRSRSRSRSRSRSRSRSRSRTGSHRNQDRTFRPPNSSPQRDRNPLQDPARAGRAAKPSRRSPSPL
The following text describes a protein:
Function:
Induces pro-inflammatory responses. Induces host TLR1/2 heterodimerization, which causes an increased recruitment of IRAK1, MYD88, and protein kinase C epsilon (PRKCE) to the downstream TLR-signaling complex that translocates PRKCE into the nucleus in an IRAK1-dependent manner. PRKCE-mediated phosphorylation allowed the nuclear IRAK3 to be exported to the cytoplasm, leading to increased activation of ERK1/2, stabilization of MAPK phosphatase 1 (MKP1), and induction of TNF-alpha with concomitant down-regulation of MAP kinase p38; During M.tuberculosis and HIV-1 co-infection, can stimulate transcription from the long terminal repeat (LTR) of HIV-1 in monocyte/macrophage cells. Interaction with human TLR2 activates the NF-kappa-B transcription factor, which binds to the promoter region of the HIV-1 and induces HIV-1 gene expression.
Miscellaneous:
MISCELLANEOUS: Shows a strong immunoreactivity toward tuberculosis (TB) patient sera compared to that of BCG-vaccinated controls. Could be an attractive candidate for serodiagnosis to discriminate patients with active tuberculosis from BCG-vaccinated individuals. Could diagnose both pulmonary and extrapulmonary tuberculosis cases. Can also be used as a novel serodiagnostic marker to detect latent tuberculosis infection (LTBI). Antibody responses elicited in TB patients are directed mostly towards the N-terminal domain of PPE17, suggesting that the N-terminal domain of PPE17 protein is immunodominant and could be used as a better serodiagnostic marker than the full-length PPE17 protein. Antibodies directed against N-terminal domain of PPE17 in active TB patients do not significantly cross-react with N-terminal domains of other PPE proteins.
Subcellular Localization:
Secreted, cell wall. Cell surface. Note=Not secreted but surface exposed. Mainly localized in the cell wall fraction regardless of PE11 co-expression.
Domain:
The N-terminal domain is essential for interaction with TLR2 and activation of HIV-1 LTR. The PPE region contains the information necessary for targeting and anchorage to the cell wall.
Sequence:
MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLYELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG
The following text describes a protein:
Function:
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTDIMTEDVQVPTSMSEYNGNVSPEKPQLQVIDIIDQIANSVEIFPYDSAASQPALLLTQESQGGVGHLVENSVYEACDISTYEDTIGMKEHQGKPEGFKEKNTGSFAQERRDWEEESGEELCQESHPTSSREQDIPEEEEWDAELCQGENIDDMAEEEQEEKKEAQLSESTEKIKEGEQSKASEKTAVKDAVGTGGGGVLKTNNEDSHKKGQENNSKEFRPIHPSCNAQTEKPDELTGTLRKNDISRHSYSRYNTISYRKIRKGNTKQRIDEFESMMHS
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MALSNTCTFCLKIVVTLILLLSLTFQPSESVGMSRKMVMGSKPPDCVNKCMNCQPCRATLAIPPRQQRSTDEKDDNYYLLSWKCSCRDELF
The following text describes a protein:
Function:
Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). Responsible for the translocation of the substrate across the membrane (By similarity). ZnuABC-mediated zinc transport is required for comF expression and competence development.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSHISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAMFLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDEATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMVFITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRKKRSR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MDVLAEEFGSLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGTVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYNE
The following text describes a protein:
Function:
Negatively regulates yodC and azoR1 which may contribute to the degradation of aromatic compounds. Probably positively regulates the catechol-specific transcription of mhqNOP, mhqED, and mhqA.
Sequence:
MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPMISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCEPGDTVCEEEK
The following text describes a protein:
Function:
Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan. Participates in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRLTRTRLCSLLVALYCLFSIYAAYHVFFGRRRRPLGTTSRNSRKAAAAQAKERRGREQSALESEEWNPWEGDEKNEQRHRVKTNLQILNKSTKEKIEHRVQIWGKAAIGLYLWEHIFEGTLDPADVTAQWREGQSVVGRTHYSFITGPAVVPGYFSIDVDNVVLVLNGREKAKIFHATQWLIYAQNLMKTQKLQHLAVVLLGNEHCENDWIMQFLKRNGGFVDLLFITYDSPWINGADILQWPLGVATYRQFPVVEASWTMLHDERPYICNFLGTAYENSSRQALMNILKQDGNDKLCWVSAREQWQPQETNESLKNYQDALLHSDLTLCPVGVNTECYRIYEACSFGSIPVVEDVMTAGHCGNTTSQHSAPLQLLKAMGAPFIFIKNWKELPAILEKEKTISLQEKIQRRKVLLHWYQHFKTELKWKFTKILESSFFINNKV
The following text describes a protein:
Function:
Required for correct meiotic chromosome segregation. Appears to also have role in sporulation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MWKFCCVTEKLTLFLFIYGICIYICIAVPIRSDLSTVFEPEAKGSRITSNYRRSLFNMLGYDNSVHPNNCKGSFLCPMLRGENRACPNAYMKYNRSLIYHGYSSYTASSCTAIYECEGDYPARTGNEIIDEFDQLNLQCSACGTRFFNNDNENTRCYVKLNYCYPDCTEITPSTSEYDYREPVRDW
The following text describes a protein:
Function:
May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MTERKAAAPRGPYGAWFCLLVALALEVVRVSSNHDTLDPIYLPVALELLDAPEHFRVQQVGHYPPANSSLASRSETFLLMQPWPRAQPLLRASYPPFATQQVVPPRVTEPHRRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLPCARLHATHPAGTAHRACRFQPSLGACVVELQFPSHWFSQSATTRAELAYTLEPAGEGPGGCGLGTEEEPREQALPVGGVELHPEDPPQYQEVPLDEAVTLRAPDVPMRPGQLFTATLLLRHNFTASLLTLRIKVKKGLQVIAARPAQPTLWTAKLDRFKGSKHHTSLITCHRAGPAGPDSSPLELSEFLWVDFAVENSTGGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDIRALIPLAKAEELVNTAPLTGVPQRIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVSEACDAVFVAGQESRGAKGVRVDFWWRRLRASLKLTVWAPLLPLRIELTDTTLEQIRGWRVPGSAEGQLEPETAAEEVERRSRGCRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAAHAHVQDPRIASLEGGRILVGREPGVTSIEVRSPLSDAILGEQALAVTDDKVSVLDLRVQPVMGISLSLSRGMSHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDRNDLGLSVSAEEPSAVLPAEEQGAQLGVVVSGVGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPLPTPVPALPSSPVRTSPFTEATVEGKRQIAGDMGGHVGIRGKFERAEEEAGKEENEAKEEEEDEEEMVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDSATDPASPQPHNWVWLGTNQEELSRQLDRCSSSGPPKGEGGCPCESGAGGDASTVAPSASESPAGSSSTLARKEAGGRRKRVEFVTFAPAPPTQPPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIRGSS
The following text describes a protein:
Function:
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Sequence:
MEHVDTLLTGGTVVTMDSAWRIFADGAVAIRDGVIVEVGPAAELNQRYTATETIDCRDCAIIPGLINGHAHVPMSLLRGLVADQQLDVWLFGYMFPVESQFVDAEFSFTGTLLSCAEMIRGGTTTFVDMYYFEEEVARAADQAGMRAICGQTVMRLPTPDADSFDAGIERARRFMAEWRGHPRIIATVAPHAPYTCTDEIYRQAAALCAEFGAPLITHLSETAREVEESIRDREVTPIRYAKRVGAFDVPCIAAHCVHATEDDLRLLREAQAGAVPCPTSNLKLASGVAPFRRMIETGVRVGLGTDGPASNDDQDMFTEIQLAALLPKGLSGDPTAVPAREAFALATCWGARAIHLDHLIGSLEAGKRADIAVVELHRLHSAPRYTYAPDAIYSHLVYSSRAADVRDVLVDGNILLRDRQLQTIDETAIIARAQAIATRINEFLATRERNLLAKILALGGVQQAEIFEIQVKARLHPADVERVLAVLNHPAITVTKTSERTQYDTYFIFANGERIRIREDHRTDPGARPQPKYTLTLMAEARRFDHPKAMMLSRARYTAPADHTVRFYREYFQPDRIEELEKQRRRWRILYRDHDFAINLDTLIGQADRGPFLEIKSRTWSRRDAERRAELISELLELIGISDDALVLQEYVELVA
The following text describes a protein:
Function:
Acetyltransferase required for the establishment of sister chromatid cohesion. Involved in preservation of genome integrity and meiosis. Required for DNA repair and for the regulation of chromosome segregation during mitotic cell division. Knock-down mutants are extremely dwarf. Regulator of sister chromatid cohesion in meiosis which negatively regulates cohesin association with chromatin, acting as an antagonist of WAPL1 and WAPL2.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MQAKINSFFKPSSSSSIAASVTTDTDDGLAVWENNRNAIVNTYQRRSAITERSEVLKGCIEKTLKKGSSSVPKNHKKKRNYTQFHLELGQSDFLLRHCAECGAKYAPGDELDEKNHQSFHKDYMYGLPFKGWQNEKAFTSPLFIKNRIVMVSENDSPAHRNKVQEVVKMMEVELGEDWILHQHCKVYLFISSQRISGCLVAEPIKEAFKLIASPDDERQLQKESSSSPSTSIQFGNIVLQREVSKRCRTSDDRLDNGVIVCEEEAKPAVCGIRAIWVSPSNRRKGIATWLLDTTRESFCNNGCMLEKSQLAFSQPSSIGRSFGSKYFGTCSFLLYKAQLIDTHFS