lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably involved in copper export.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFDENQTNLDEIFKLIEKLGYSPKKALTKEKKEFFSPNVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLAIDNHSNFLNACLQLIGALIVMHLGRDFYIQGFKALWHRQPNMSSLIAIGTSAALISSLWQLYLVYTNHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMQNNQQIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGTFNSHTSFLMKATQNNKNSTLSQIIEMIYNAQSSKAEISRLADKVSSVFVPSVIAISILAFVVWLIIAPKPDFWWNFGIALEVFVSVLVISCPCALGLATPMSILVANQKASSLGLFFKDAKSLEKARLVNTIVFDKTGTLTNGKPVVKSVHSKIELLELLSLALSIEKSSEHVIAKGIVEYAKEHNAPLKEMSGVKVKTGFGISAKTDYQGTKEIIKVGNSEFFNPINTLEIKENGILVFVGRAISEKEDELLGAFVLEDLPKKGVKEHIAQIKNLGINTFLLSGDNRENVQKCAFELGIDGYISNAKPQDKLNKIKELKEKGQIVMMVGDGLNDAPSLAMSDVAVVMAKGSDVSVQAADIVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANLMLSPAIAGLAMSLSSVSVVLNSQRLRNFKIKDH
The following text describes a protein:
Function:
Involved in the presentation of foreign antigens to the immune system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MPSLLLLLFSLPHCLEQCLTHGKRLRNNHHDDYQCRGGGGKEESLCVCVCVCVRVGYLEQGSHSLRYFTTGVSRPGPGVSEFTSVGYVDDVQFVRFDGDGRRGRAEPRTPWIRDNEGREYWDQETEIFRSGAQNFHVGLQNIMGYYNQSEESECGSWARGSHTVQGLYGCQLREDNTPGEGFMQFGYDGRDYIALDKATLSWTVADAGALNTKSKWEADGTIAERYKAYLEDECIEWLRRYMGFGGPCLTRADPPKVDVIRHPGPDGEDVSLRCRAFGFYPADIKFMWRREGEDVSLQMELVDTRPSGDGNFQKWASVSVPRGEELKYVCVVEHEGLAQPLAVKWAPRPLLSIALSTGPPPASSHFFFFPQVPEEGTNPLQVSMDVIGWRGDGGDGEKGEGPTGWAGKGWGPGFKRDQLPAPDSIIIIMLVFVKRLLRAEHCSKRWGRHRGIRLSQETLTRLPLPLPRL
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MGPAARLAALLALLALRAGDRAGAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDKVLSLHEDSATPVSNPLLAFTLIKRLQSDWRNVVHSLEASENIRGNEEEGWRGLCLPLGTKENQTSSLLMKYSTLKDGYEKEEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAVTDLYSPRRLFSLTADDCFQVGKVAYDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEGSLEDALDHLAFAYFQAGNVSCALSLSREFLLYSPDNKRMARNVLKYEKLLAESPNQVVAEAVIQRPNVPHLQTRDTYEGLCQTLGSQPTHYQIPSLYCSYETNSSPFLLLQPVRKEVIHLEPYVVLYHDFVSDSEAQKIRGLAEPWLQRSVVASGEKQLPVEYRISKSAWLKDTVDPMLVTLDHRIAALTGLDVQPPYAEYLQVVNYGIGGHYEPHFDHATSPTSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANFSVPVVKNAALFWWNLHRSGEGDSDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPCSSSPED
The following text describes a protein:
Function:
Involved in the catabolism of purine nucleotides. Can use allantoate as substrate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MITPLLFLQLCVLSIVLPTTSSAFMLSGREDDLFAEILRDEAVSRLNQLGKVSDADGYLERTFMSPASVRAANLIRAWMEDAGLTTWVDYMGNVHGRVEGLNASAEALLIGSHLDTVVDAGIFDGSLGIISAISALKVLKSNGTLTNLIRPVEVIAFSDEEGVRFQSTFLGSAAVAGILPVSALQISDKSGVNVQDALKENSIAITEESLFQLKYDPQSVWGYIEVHIEQGPVLEWVGFPLGVVKGIAGQTRLKVTVRGSQGHAGTVPMSLRQDPMAASAELIMLLESLCKNPKDFLSYDGHCNDSTVESLSNSLVCTVGEISTWPSASNVIPGQVTFTVDLRAMDNMGREAVLYELSNRMYEICERRSVSCIIERKHDANAVICDSELTSELKFAANAALKRLTGEIQDEVPVLMSGAGHDAMAMSHLTKVGMLFVRCRGGVSHSPAEHVLDDDVWAAGLSILAFLETHM
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MSRTDKSFLAKKIISSDGPSPAEEDHNVPLVEWCAAGIEPEEEANRRRSVLEHINCIVRAWIRSTMIAEFRMPAEAAAQVEGRIFATGSYRYNVHGSGSDIDIVLIAPNRITREHFFNTLAPRLSHESRITELHCIRDARVPLIAMVADGIDIDLSFGSIRQDRVPEVITDDLLQGLDDQSVLSCNAVRVAHNIMDLVPHKASFRQALRFIKAWGKARGIYSNTFGFPSGIGWAILVAFVCQCHPNQNAAGMVVRFFRIYHTWFSPNPHGSGRENRAIYLTETMRVKTNLGRGWDPRESKSDALALFPVLTPAVPYGNACYNVTMTNLRQLCDEFARGHEICSSYIGMGVEETKMKLGPHGIWSKILEPVKFFGEYKYYLHVQVTCTDAEAYQGYVDAVESKIRFLWAGTAESRAQSLESFPHVRLRLNPKGYEAPEEVEARSRLLKKAPRGGGIPESGAQGRAGASSNGNSSSVSSAVGGGSAGTAVKSFSRHYYFGMSVDSKAASMKVDLAPSIRSFHNIVRQLRQYRDGVTRLPVITVEDMTKIPAFVKAAAGYKDPVSTTESDAGSGRACTPSEADTATSSNGAAAATAGASEAADKSEGAPSAETAGVKRHRGEDDENDAAAMKVVAKDSVNSAIADHAGPKLGKGSAEGGGARRDNSTGHSKVSQDDDEELGLEQALGLGF
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Sequence:
MKPVIILLLLAVLDVTDSQSIRSRQKRAWIIDSLTIEEENPGPFPYSLGTIELESEYRMLFTLHGSGVDEDPKGILQINPSTGEIRVLGKVDYEKYHKLKLQFEAKNASTGILDTRLGVEINILDINDHPPTFQNTLYETTVKESTYQGNSLIIVSATDLDKPDTTNSTFSYRIASVSPMTKDVEFTINEKGTVSFKGCLDYEQTEKYTIIVEAKDHGEKVKLSSSTTVLLTVQDVNDNLPIFLSPKLTVKVKERYEGVTALRIKVNDKDKKSTSAWNAKYIIEDDKDGNFQITTDPETNDGILTVVKPLDFEKCNGRNLSVTVMNEEDYSSCTVKKQNPTGRWNVEMKHYDASKRHLLVLMKQTVEVILEDVNDPPEFTPTIKNIYIAENTETGHELETMTAVDLDDKFAGEFVYEIGNDPAGWVTVDPKNGVIKTIKKVDRESSHVVNNTYTVLIHAVDKGIPPMTGTGTLIIHIRDENDNVPFLRKTNIDMCSGAGATNITPYDLDEDPFSGPFRFQLVNEKDLEGKWRLDPTYGHSVDLIKESDVFSGVYEVSLKIFDKQEQYSIQNLTVTVCDCVSSGPANCRFRKSPATQMGGSAIGIIFASLFLLLGLLLLGFLTCGVKKSFMILDDDSTNTFIKSNIETPGTDCTVPNTAQKFQMTEADATNNQHVKNYYGQAHKNIFVQNVNIHRSQSNSQFSKIGQQVHHYSQMGSEWSQQTVLTKSINIERMKMKAKINKKVLLIQGNGNELHDYPPHIYADEGEPMSDPELDAISIDEQEFVSDQLNDLGPRFINLATICMSSLKTLRQNN
The following text describes a protein:
Function:
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Sequence:
MELKRGKTFIKSSLQVSHEKPPDPAAVAAAREGTGPWSVLPGGQQRPHSEKGPQASPSAQEYDRCPNKGAQLDPKGGPAALCGATFKPVRKCKTHDSMSGAGRATAATGQLVGSASFPGSPGSRRMIDYRHFVPQMPFVPAVAKSIPRKRISLKRPKKCFRNLFHIRRNKTEDLASLAAEGKSLPSPGDPSDPGGRRSKAFLPPGEGPGLDGLCQDLLDSELLADASFGLCRALCEDVASLQSFDSLTGCGEVFADESSVPSLELNEGPESPTQAAQGLESKVPRGPLQGSVEQLASPAQNEASDFTRFWDSVNRSVRQQQRALLGPWLSGPQGTDRDQSRLDTAGLAELPLCPCRDPRSGSKASSIDTGTPKSEQPESVSTSDEGYYDSFSPGLEEDKKEAESPGTPAATFPRDSYSGDALYELFHDPSEGPLGPSPDDDLCVSESLSGPALGTPLSICSFRVGAEENLAPAPGPDLLSQGFLQSSWKGKECLLKLCDTELAITMGIVSWLRRGPTPRAPPTPGQPAAPPGSQGAPRAPTEKLGGREGLASDAGGATVCSAPSRQELWAHPGTTGLLAGESKALGGATQGTGTLSRDASREEETRGHSEGLFSSMESAATSTTDTSGKNKAPVPSTWPCSQKEPGPPGVLGCFRGPWRPGHGGDTLDAEPMLAGCVARVAALKISSNEQPPAAWPPRQDMGSGLFGQRWARGPDMLEQKQSSSSPSMTTIHGLPYSASTQDQRCRDRVQDLSWLRVEPTGLGVQAWASVEDQPLQLSTEAVEQVAHGSQLDSEPRSAPAARWSSQGHHPESLGLTLNSQQEGGVSASAPECRCSLLAREGLLCGQPEVGASGPAMAEPHL
The following text describes a protein:
Function:
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIRPLHDRVIVKRKEVESKSAGGIVLTGSAAGKSTRGEIIAVGKGRILDNGTVQPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
The following text describes a protein:
Function:
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.
Sequence:
MESPLDVGSGPVKVRDALLGLTALNHDVVLLDYGNVVIQRDYRNLSKVRLLSGGVAGTDLIHAVCVGKGMLTAAILGEETVPSSRQILHTIKELNEGDNCGICVIVQANADLFNFGLAVERANTDCRTRVKLLPINDDKSAKKERYSCGFILLAKILGALAESGALYNDVCECYKQIIDQIITVPLNYTHDGSGTRKRKSLVLSDFESNFRHIIDKKSQVFLGLHPSIPTVALINASRTMERYVELSFVKQVIERLKELGVCVVRIYYGNFISVAPGTAFLTVMKVHDMKIIDYLDAPCGATGWRHFTQFLPEISAQNEIPGLLTHYGKQHIKLKGPKLGEFQSSILVKAVQFACDALISCERQLNIIDEEKSDGNVGTRLKNMAEGVNKRINSKKLPISCPYGFLKKMGIIAESAIGGAMGSIYGVMFESAANLFGGLPDTETVTPGMWAKAFTVGVESLKRYCMREPDEKTMLYPLKRSDVTIRNEMEKGEHYLQYFGLGVSAAEEAAQETKLPQSKYSDAGAHAVGIWMRAVLEGVKLMTGGNLCEGESLNK
The following text describes a protein:
Function:
Regulates membrane-cell wall junctions and localized cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Sequence:
MKTGSVEAGEQASEDATPRRGKKLNRGILILDLVLRVFGAICTLGSAVAMGTTSQTLPSSSQFFRFRAKYNDLPMFMFFAIANSIVCAYLVLSLRLSIFHIIRSAGIITRIILVTFDMVMLVLLTCGASAATSIVYLAHKGNASANWLPFCVRFSHFCNRISGSLIGSFFSIIIFMLLVILSAVSQFSICN
The following text describes a protein:
Function:
May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLKTSPVRDIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGSQSSDYISPMCSCSSECIHKLGHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDFYGEKAKNQGGVVLKASVLEEELKDALIHQMPPFISAQKHRPTDSPEVNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHSCHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGPLEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINKINVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCDETTSVEKMAPSFDTDSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQMQKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKNSEKSLERNHLQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTKPRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTGHLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAESLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNSSSMEDADASVYEVEEPYEAPDGQLQLGPRHQRSSSGASQEEQNDLGLGDLPSDEEEVINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCFQELQKLDHQHSPRIVSPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTVTQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MHMIQRVSSIGLRTLRSSNIGSIRSLIVLPILSIKPTYIRQTQAQINLKPQALLLNLLLHHHHHHHHYYSTKTAPPPPPPPQPPQDKNAKGKKILNRINRAFTFSLSTLLVVGAAGISVLVVSLILSELFLPSGDTRTFNKAVKLIEKNEQAQKALNFQSGQRLKAYGIVSADKWVRNRPVQSVKTKRKDGKDHLIMKFQVESDNGKYGVVSLEQIDNSMWNTEFEYISLDVPGFKRIYIIEPPKNQLIPKIGGGSGFLGLNWGPKKD
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells. Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells. Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis. May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIITGAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MYVLCGSGYEQASVGSMAEERTVCDLKGLKKQLEGLLGRYSRDELCSDTERFCSDFCTLVEEHAARWQLPLPQLTVLEIALCYFARASSCFPSNCDPALQTISSLALSVFELLLFFDHNDFSQEPLERFAATFQECHLVLGRHQNLHLLQVERLVGSGGPWASPVLQAILSQSSLPQHEVDAYIGSELPIFFELRVRFLLSRSRFGEAAALAKHCIRHPGAGQHLFFLQVYLTWLHKTSQQDCLHKEVADVSGKDAVHVLCSLESDEKDELLLALGTAFLSQQLRRGDMYYLCDLVLVWTNLHGRLKTSPQVFLAECRQLMKSATNVKSIFPFIRAVLQTVGEAGVQFCIELCANALQARLPCDVTTKSLIYKTVAALLPNDLEVCRACALLVFFQERTVESYKMVYLLYMLPDQEYHAEDSPIGNHVRFETLQVLKKDLHFDPEFWNLIALRTNCLKLMNKKVVSPVLEEIMEDRWISKYCAKDPAPRSVCRAKDKSNVLSVAKKRHQNQTSTDAASKRLKTSAGKTRHDDRATKRRGARALQESSARSLRRSFWQLDRIHGGVALRYDEQRRTTRLSEKNPPKRRIRKPRWLLEDSGALEENVPVRIKRNGLKRGKCLPSCVMKRSKMGPMKNAKPLVASQLKANHGNQNGFPSDAVSPPSPPQVILELSLPDNELMATFTEDAYTRPRGFPQVLFYKSTVKRAAAPSPEKTAHGKEVVLRARDPSMFVQQLHCYGRRQKDKGTSSQVHASVSTITRSSLQGSPPKDSPRDQTAETGAVKAQSTKPPTRKGGATGEPTEEPKLIQEKGLFRASRDLQNCSKVETLPTPKPQDAPQSSPAKPCEELAMNSTVASLPPLSDRVSEPQNVENRPQTTKVSEVNHPIGINVPNAEDQVLCQDGEEPLRTLSSQVGNPSEQEQDDRSSRRKQSDPEVSHDASQQDGTGDMSVQPEGEQAVPERVPQEDKRGPPEDSASGKPRPETELSRPEEMRTPFLAPQLHNIKEEAMAHEIGFDAPEGSEFKETFPESEESRLEYCCIFCEKDFHGCRVVAHAMFHYRRDECMFCGTVFTDDLLAMIHLSDHIEKLKRLKAPAAPDDDAKDSPAEAKPSNASLASGKRGRPRKSSTPQKLTDSGPSEPRTLRSDHKQSQKPQTPHRVNGHMSKKFSRSRRSVDTKEEPVQQEISLEQPGSEEGSSTSMRAARKSACFKEEEKTEPPKVPKKTQKEKKTVDPLERARCAVVGCSWSADISKNRVAPLYHALEEHYGDTTALQLAFRVANGKCGICSRVMFSFEHFLHHVGRHRDSPRHPCLHQGCGARFKSGMEMRRHARRHSPLQAVCCLPGCSQLFICLWALNLHEKEHFSARPGKPTKKANVQTGDKTPAGRTRRSSGDSSGDPAASEEPAVKIKEEGAPESPLRENVKAQKDDKDPKVLKNLCSQEEPEQPSAPRLRLRRSSSEAHRAPPSLMSKHRSKARNRLKKLQVRAKSKRRRGRPLKVSTATTVENIHAARNPSKVKTTKTSAGDSNANLRRVTKLRDRRKPLSNALKLEKPQTKLHKIRDRHTLSKTKKKKTTRSDDGSSAKKPSGSAAPRSDAEASSVDAPPSPTPRTTAAEKQPEGIAPTTEKKSGLKESSEVQKEQEKTSAPQKMKLKRRHQADSTEAAVVQKGGVGESRTPPSADALPSADALPSADALPSADALPSADALPSADALPTAEALPTAEALPCADALPSASALLSASALPSASALPSADALPSADALPSADALPSADTSTSSAPPDIQQKKKKKSATREKQTETKLKKKGRGGAASTAVQTESSAGHAPETDAPASAHTMNGKASAQLQKTSVCNETLALYSKKPYLRVPPTAYLDEKYTAMPKRRKTSFPPPPDNAASPEQTAAAPPQRQRCAKCFATFTCSEELRGHLQRQNCSKLFGFDSDEEEAHS
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MTENAPPSSSKDAAADTSRGMPYYERLRRDLRESLQKKRAIDNNLLRLEEEILKAETTYLEETSTGNIIKGFDNYIKGTTTTAAAGGAGTATRRKAPISDADRIFSRSSTSFLRESSTPGSAQTPSSHAPTPTSSFPTRESSQPTNGMRGGGGSKKKKVGEDDDEDGKSIKRQKISYGRD
The following text describes a protein:
Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
Subcellular Localization:
Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Sequence:
MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQIRKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVSLVQNSRKLQNIRDNVEKESKRLKIS
The following text describes a protein:
Function:
Plays an essential role most probably in virion tail assembly. May form a scaffold around which gp11 and gp12 polymerize. Gets ejected from the infecting particle into the bacterial cell.
Subcellular Localization:
Virion. Note=Component of the tail.
Sequence:
MGKKVKKAVKKVTKSVKKVVKEGARPVKQVAGGLAGLAGGTGEAQMVEVPQAAAQIVDVPEKEVSTEDEAQTESGRKKARAGGKKSLSVARSSGGGINI
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MAPKVLMVAEKPSIALSIASALSGGRMSTRRGSTDVHEFDGMFQGSQAFFRVTSVIGHVFSVDFPPAYQNWEATDPMDLFNAPVLRSESNPKAHIHRHLAQEARGCTYLVLWLDCDREGENICFEVINCTGIPENEVGRRIFRAKFSSVTEKDISNAMDNLVLPNKDEALAVDARQEIDLKVGVAFTRFQTRYFQGKYGNLDSRVISYGPCQTPTLGFCVQRYQQINTFKPEKFWSLRTYIIKDGDEIQLEWERKKLFDFDVTVMFQKMVASDGALKITDISVKEECKARPPGLNTVNLLKVASSALGIGPQTAMHMAERLYIQGYISYPRTESTAYPASFDFRSVLSTLAHNPLWSNNVRTLMDAGFVKPRQGHDVGDHPPITPMRLAPEEALETDAWRLYQYICQHFIGTVSHDCRYTRTAVEFTSGGEIFRCVGHRVTSKGFTSIMPWLAVGENNLPTFKKGDTINIHKVDIYEGSTTAPDYLSESELISLMEKNGIGTDASIPVHINNISERNYVQVNTGRRLVPTALGTTLIRGYQCIDADLCLPDIRSFIEQQITLIAKGKADHLQVIQHVLEQFMRKYSYFVKKIENMDTLFEAQFSPLADSGRLLSKCGKCGRYMKYISTQPMRMYCVTCEEVYYLPQNGSIKLYKEIICPLDGFELLLFSMVGPDAKSFPLCPCCYNSPPFEGIDKLFGALKLDDTGKVGKGAGMPCFLCPHPTCKQSMITQGVCACPECSGTLILDPVSAPKWRLLCNTCNCVVLLPHAAHRITTTDKKCPTCESTIIEVDFNKKATPLEDGATLHEGCILCDELLHSLVEMKHGKSFFMRRGRGRGRGRGRGRGGRGRGRRGSLRHDDPKMSFRDF
The following text describes a protein:
Function:
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.
Miscellaneous:
MISCELLANEOUS: TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-cell propagation. TGBp1 is the main movement protein that physically cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would facilitate TGBp1 function.
Subcellular Localization:
Host cytoplasm.
Sequence:
MDILIISLKSLGYSRTHKSLDSGPLVVHAVAGAGKSTALRKLILRHPTFTVHTLGVPDKVSIRTRGIQKPGPIPEGNFAILDEYTLDNTTRNSYQALFADPYQAPEFSLEPHFYLETSFRVPRKVADLIAGCGFDFETNSQEEGHLEITGIFKGPLLGKVIAIDEESETTLSKHGVEFVKPCQVTGLEFKVVTVVSAAPIEEIGQSTAFYNAITRSKGLTYVRAGT
The following text describes a protein:
Function:
Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Active under basal conditions. Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons; (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein. This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=(Microbial infection) Following SARS-CoV-2 infection, colocalizes with SARS-CoV-2 ORF3A protein at the endoplasmic reticulum.
Domain:
The LIR motif interacts with ATG8 family proteins and is necessary to target the ER fragments to autophagosomes for subsequent lysosomal degradation; The reticulon homology domain provides capacity to bend the membrane and promotes ER scission. It is required for homooligomerization. This domain does not show relevant similarities with reticulon domains, preventing any domain predictions within the protein sequence.
Sequence:
MASPAPPEHAEEGCPAPAAEEQAPPSPPPPQASPAERQQQEEEAQEAGAAEGAGLQVEEAAGRAAAAVTWLLGEPVLWLGCRADELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRTRGAQLWRSLSESWEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLCAFLCPLFKCNDIGQKIYSKIKSVLLKLDFGIGEYINQKKRERSEADKEKSHKDDSELDFSALCPKISLTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFPSLENGMGTNDEDELSLGLPTELKRKKEQLDSGHRPSKETQSAAGLTLPLNSDQTFHLMSNLAGDVITAAVTAAIKDQLEGVQQALSQAAPIPEEDTDTEEGDDFELLDQSELDQIESELGLTQDQEAEAQQNKKSSGFLSNLLGGH
The following text describes a protein:
Function:
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWRCVQAGATYLCVQLCKMLFLATFFPTWEGAVGAYDFIGEFMKATVDLADLLGLHLVMSRNAGKGEYKIMVAAMGWATAELVMSRCLPLWVGARGIEFDWKYIQMSIDSNISLVHYMAVAALVWMWTRYDLPTHYRLPVTVLLGLSMYKAFLMDCFVHIFIMGSWTALLLKAVITGVLSLSCLTLFVSLVHGN
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
DILTLDQFQLSPDPPVRGSPLEIQLIGTLSEAVVKGAVAQVTVKLGFIQILDRPYDLCDQVSAVDLQCPISEGPISVVKSFDIPKELPFGRYRIHVDVKTVDDRHIGCLSA
The following text describes a protein:
Function:
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).
Sequence:
MNFRELDTSNGVKAAESSFRTKVVLAREIPWNGFASSNSITSEQYNLISKYDKHTDAEKKEKFAANSASYVNFFVNFINSTSNIEIIQYLLTLINEIIEIDPRAAGAFSKITKDDDKSYPYSVFFRLLNREDAYTNLHASIALAQIMCAGKPTQNDVESFFNWILKLLRKNNSSEVEVGLIALQSLLLKDDFRIFFNNIDGSALLLNILQALSTSSVNIQLLYETIYAIWLLTYNKDIAAAYSGTGLVANLVQLVKTVAKEKIVRLSLSTLRNLLNNGKSNEEMIDNGFVRMLNILNIKKWGDDDIPADIEVLINGLAKDIDNMSSFNKYKTEIISGELEWTPVHKSERFWKENISKFEENNYQVIKHLHQILKTSQSTPLQLSIACHDLCEFVRHHSRGKAIMTITNQTRYHGYDVKSNEEVKNQALFALQKMMLNNWEYLNAK
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MTDVEPVVTDFAASGRAGRRNALPDILGSSAGAGTSDLPHKLAELSMSEEASSSGTTMENQETEGKSMDS
The following text describes a protein:
Function:
Catalyzes the decarboxylation and hydroxylation of 2-oxoadipate (2OA) to form D-2-hydroxyglutarate (D-2-HGA). Is involved in a D-lysine catabolic pathway.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MISLHSSAIKASLYGSFPSSLRSTLSVSFSAGSLIRLPSVGKRNLSVVVSSGRDSSMSSNNVSRGSSSKVAAESFFRSVLGQMETVYLNRNPTPKSVLELVRSVDDQQLCYDHLAFRTFGIGGYGIDSLASFFLDYGYTPMDELKFPAKKLRALWFAPPNASAVPGGSGVNGPLPRVFISELLVDQMSSQTQDVIRKYTEASPNGKKYAGLSSALGTLTWEKPLSSEFEQLARESEYAAWTLVNGYALNHVTISVHRLKSHLNKIKKLNQFLEEKGIKLNSEGGVLKVSPDGGLQQSSTVADSISFKFADGVTKSIPCSYIEFAERLVLPQYQNIPESEIQESHRRDGFEVGNADKIFESTFQEQLSRRTG