lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the insertion of proteins targeted to the outer membrane of chloroplasts. Required for the import of protein precursors into chloroplasts. Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane (By similarity).
Subcellular Localization:
Plastid, chloroplast outer membrane; Multi-pass membrane protein.
Domain:
Transmembrane regions consist mainly of membrane-spanning sided beta-sheets, which are not predicted by sequence analysis tools.
Sequence:
MALTSQSLFFSPLAAGPSRRVRGRGRSTSVSAAASASSHNSQPHGHPQQPLAVASSSSKSESKGSKTFALASAITAAASGAFLLASSGGGFGGGAGGPLGGGGGGWGAGGGGGGGGGGGGGGFWSRIFSGGAAHADEKSSGDWDPHGLPANINVPMTKLSGLKRYKISELKFFDRAAGGGGAFTGPEDSFFEMVTLQPGGVYTKSQLLKELETLVSCGMFERVDLEGKAKPDGTLGLTVSFVESVWSAAKQFKCINVGLMSQSGQVDFDQDMTEREKMDYLRKQERDYQQRVRGAKPCILPDNVRGEVLGMMKKQEKVSARLLQRIRDHVQKWYHNEGFVCAQVVNFGNLNTSEVVCEVVEGDITKVEYQFQDKLGNFVEGNTQIPIIDRELPQQLRPGHIFNIGAGKQALKNINSLALFSNIEVNPRPDETKEGGIVVEIKLKELEPKSAEVSTEWSIVPGREGRPTLASIQPGGTVSFEHRNIYGLNRSIVGSVTSSNLLNPQDDLSFKLEYVHPYLDGVDDRNKNRTFKTSCFNTRKLSPVFVAGPNMDEAPPVWVDRVGFKANITESFTRQSKFTYGLVVEEITTRDETNSICTHGSRAMPSGGLSMDGPPTTLSGTGIDRMAFLQANITRDNTEFVNGAVIGDRCIFQLDQGLGIGSKNPFFNRHQLTLTKFVNLNKQEKGAGKPLPAVLVLHGHYAGCVGDLPSYDAFTLGGPYSVRGYGMGELGASRNVLEVASELRIPVRNTYVYGFVEHGTDLGSSKDVKGNPTEFFRRVGHGSSYGLGVKLGLVRGEYIVDHNAGTGTVFFRFGERF
The following text describes a protein:
Function:
Component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control. Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Involved in delivery of substrates to the 26S proteasome. Also required for membrane fusion (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 233 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MDIFRHTFGNNDDSFIRIPGAFREEPPADLNGRTEDQNSNTNEPTQSRDGRLKSILHFLFQAPLIVLYYLLNFIVRSSRLLKPLLRLHGFYQRKHNRLLDHSSQLHRLLENLENEAQAVTCSEGNGNNDDGSNTDSTSNNESSGVQFSFGSLYNPENGTFSKSIMQNSYTELLDACSEQVKFGVIYLHDPLLDNHMDYVNKILCSEAFVNMIRKYQVLLWYGDVTTSEGLQVSNALKIRQYPLLGIISLKAEKKIELIARVEGSISNYKAQDLEAIFSKNYSRLIQLRQQRQNIEMQRLIRQQQDSRYQDSLRRDQQRESERLEQTQREQMEREHQRIENQWLLWRKSQLKPEPSSDKDASKVAIRLENGQRLVRKFDASLPTEEIYAFVELQLHDMLNSENDTLPVYQPANYQHQYSFKLITPVPRRELDLSTKISDVSGIYPSGNIVMERLDE
The following text describes a protein:
Function:
RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, P-body.
Sequence:
MSDFGLLRSPLTPSNASINRASSPSGHRPITMNPHSRYSLGKGASTEHMMRLAQHGNAGHDGALRSPSIGGNAPMPGSAGPRNLRPSSEMLPNMNHHGTPESEAIDRWFEDLQHYEATLEEMAAASLDQNFKEELSAIEQWFRVLSEAERTAALYSLLQESTQVQIRFFITVLQQMARSDPVSALLSPSHHNSTMADQMEAKLASLGLKSPSALKSPASPGNRGYRQSSDAAGFLSPNVAAMYSPGNTDAASTLAAQRAKLKANRTSAPGTLIGESRNYSGGQLDQVQERGGSPNLQQQRTLSGDHSRPKSTDFSNNNVGRSPRASGPLDDQLSPISATGNWSSMVNTPLVPMFTDNDKAGTGEANVNLDTAAAQLASLQQQQQVGGNGRVMVDPDVPRFRRKSNQNIGGGGSSYGQGPNLYDHTSPGVSPNIGVPSGWGQSDNFGRGGLNTGLSAFGGNNDSNSNQFNIPPMSPNALAGLQSPSGGLANPLNMQVMNMMAAMGGLNLNNMNGAQLLAMQQQLLQNQQALSMLAQQQQLQQQQPHGRNLGNFGGGGLSPGLAGQAGRKSPRSGTSPSVRAAALPGAAGGAGSGGAGASNAAGGEEEVADLSTLEDVPAWLRQLRLHKYTPNFETSHWKEMVMMGDKQLEDKGVAALGARRKMLKTFELVRKKYGIRMDGEDRPGSGVPDGNNDKAADVDDAGDSNEAQEVDRELGGAATAASAPVAKD
The following text describes a protein:
Function:
RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly nuclear. Small amounts are found in the cytoplasm.
Sequence:
MNTQTGTGTSEVSKKLKAAIRAKLEELGVYVDDELPDYIMVMIANKKEKVQMKDDLNLFIGKSTAKFVDWLFDLFDRLQNASNKQGETSKKEEDKRKELEATAAAKEHEEKRRKEKEEHEKELQKEKEREKERQRERDREKRAEEEKRREEKRKEIQRSKRRRTRSRSNTYSDEEEHVRARGEKHDRHHHKDHRRGRSHERKIITSTIVRQASASPDKKLHSTVTVKRNIRPTGDQNIKGRGTMFLRAMNEASVSAGYGSSSKRSETHHEDDMSDVEALPSKPASTKSPKKSIRDRMSRISKTSEPPIEEDDAVVLEDFAQTGGGPQMILKLSGGREAIKKTRIQDRIVVDDGLRRGLLKRKIETASGASAGAATSEEPKSKHDRIIFDITPSRDSTPTDDSPTMQKWNGQIEIGDDSEESEDDEEAEIDAFVAEARGIARRESFRDEEDELPPTHQLSGGPYAYHHSTAAPTYIPTPLSVLSEQQNQMGGGAAKEDHHVKERCIFWPKCTKGDTCAFMHPTTNCKNFPNCTFGIRCLFIHPPCRFDRFCTKKHCPFTHHGTGGQQPGGAQLTSEFKNPLTSSRMLTVPSPFIAATAAAVEELPKPAARGALGSLAEKLAASIKKKPAPGAESEKKEEKSDENESKAEEPKAEVAPVQPKPLPDIAPLHSMVLCRYAGACRNPICHFKHPKECRFGANCRNPSCYFYHKPAGAAPTPVAAPIAAESAGAAKYKWTSATAN
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Sequence:
MSDVSEPVAHPPVTDWVNDFDHTDPQWTDDPFPIWDELRAASPVVHTERFLGCYMPTTYEAVREIANDTEHFSSRRIIVRDVRPEIARNAAPPITSDPPVHKPAKQLLLPPFTPDAMKKLEPRVRTICNELIDGFISDGKVDAAARYSKYIPVRAIAHMLGIPESDSDLFVNWIHMILELGIKDETMLLQAVQEMSAYFRTHIEERRSRPTDDLISYLMNAKDKEGQPLEESHVLGSLRLLLIAGIDTTWSAIGSSLWHLARTPADRERLIAEPGLIPIAVEELLRAYSPVTMAREVVKETTISGCPVKAGNMVLLSFPAANRDPKMFPDADKVVIDRRENRHAAFGLGIHRCVGSNLARMEMQVALEEWLKRIPDFRLDPAGTVTWSQGTVRGPRQLPFLLGKAM
The following text describes a protein:
Function:
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVRGAVPRWTFPFRPGAEAESSGRGKAPTHARGAFMCGIVGYIGPRQAQDVLLSGLSKLEYRGYDSAGVAVGDGACIAVRKKAGKLANLAGDLQAAPLSGSFGIGHTRWATHGLPNDRNSHPHTTEDGRIVLVHNGIIENYLPLKEELLARGHTFKSDTDSEVVAHLIEEAYQGNLEEAVQAALAQVRGAYALVVTHVDHREIVAARTVSPLVMGVGEGEMFLASDVPALLAYTRQMVFLMDGDMVILSDDGYRVTDLQGHPVQRDVETIEWDAEAAEKGGFDTYMLKEIYEQPQALTNTLLGRLRDEQGAVDLDISLDPTSFKRISIVACGTAYYAGLVGEYLIEQLARIPVEVDVASEYRYRNPLVGENTLAIAVSQSGETIDTLEAMREAKKGGAQTLGVINAKGSSMTRELDSTLYIHAGPEIGVASTKAYTSMVSAFLMLALWLGRARGTLSDAEGAELIHAARELPRLVEDALKPERVQRIKEVAEKYAHARDYLFLGRGVNSPTAFEGALKLKEISYIHAEAYAAGEMKHGPIALIDENLPVAVIATESRLLEKTISNVQEVRARAGKVILFLSDGDEENALHGDDVVYLPRAHELVSPVVNAVAMQLLAYFTATALGKDVDKPRNLAKSVTVE
The following text describes a protein:
Function:
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.
Subcellular Localization:
Nucleus.
Sequence:
MDEQGRLMQARGVGIPGHPIHGGPQTLTPHPMHEPPADNGEPRKQDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRNTQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGVSPDNSIEHSDYRNKLSQIRQIYHAELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVAQGGHSGANSPTTPTSAGSGGSFNLSGSNDMFMAMQGLNGDSYPPSQVESLRHTMGPGYSDSLSANQMYSPREIRANGGWQEAVTPSSVTSPTEGPGSVHSDTSN
The following text describes a protein:
Function:
Serine protein kinase that inhibits the mitochondrial pyruvate dehydrogenase (PDH) complex (mtPDC) by phosphorylation of the E1 alpha subunit on Ser residues, thus contributing to the regulation of glucose metabolism.
Subcellular Localization:
Mitochondrion.
Sequence:
MAVKKACEMFPKSLIEDVHKWGCMKQTGVSLRYMMEFGSKPTERNLLISAQFLHKELPIRVARRAIELQTLPYGLSDKPAVLKVRDWYLESFRDMRAFPEIKDSGDEKDFTQMIKAVKVRHNNVVPMMALGVNQLKKGMNSGNLDEIHQFLDRFYLSRIGIRMLIGQHVELHNPNPPLHTVGYIHTKMSPMEVARNASEDARSICFREYGSAPEINIYGDPSFTFPYVPTHLHLMMYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNPLEEDVDLGIADVPVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLGDSQEPLP
The following text describes a protein:
Function:
Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLRKSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFGRIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGETIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQNQIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYVSSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGITWKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRMEQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQREQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTRSAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAASMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDGADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHAHMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLYTACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP. Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). In vitro, can use pGpG as an alternative substrate and hydrolyze it into GMP. Acts in regulation of motility, synthesis of virulence determinants and biofilm architecture.
Sequence:
MLKRIPVTQLRLGMFVQSLCGSWLDHPFWKRGGFLLDSQADLQRLRESAVKEVWIDASKGLDLPEEAAVSAAAVLPVTMPAGPSPARVALEEEIRHAALLCSRAKAAVVSMFRDARMGQAIDTAHASDLVDEISASVLRHPNALLSLVRLKTSDEYTYMHSVAVCALMIALARQLELPDPLVREAGLAGLLHDIGKMAVPDPILNKPGKLTDPEFGLVRRHPQNGARMLLDCRQVSALVVDVCLHHHERIDGTGYPFGLAQEQISLLARMGAVCDVYDAITSDRPYKKGWNAAEAIRRMAEWNGHFDPQVFRAFVKAVGIYPVGALVRLESGRLGVVLEQHGRSLLTPRVKVFFSARSKVPIPQQVVDLGRAGQTDRIVGFEPAEAWNFRNLDEMWTGLAKSTGSYFDAGTGNP
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MPYLYRIAYDGTMFYGFTGHPNSLEPRLRLIFGEILGRGSRTDPGVSAVGNVVMTGRKMALGYVNSKMPKGAWAWGIAEVPEGFNPRRAKLRRYLYVAPHWGEDVDVMREAAKLLTGTHDYSSFIQLRGEKHTPTVTTVYDIDVTLRGDLIFIYFAGRGFRNKMIRKMAWALLAAGRGVLSVDDLADLLKKPRPGAVPSAPAEGLVLLDIVYDVKFEVDFSALRKAYVYFLSKSRHLSAHAAALRAAGEALAMWES
The following text describes a protein:
Function:
Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).
Sequence:
MTSIIARMSNSRRQNTSLPPWAHSMLRSLERSLGPLMAILAERNLKLFSGRVVPAQGEETFENWLIQVNEVLPDWNMSEEEKLRRLIKTLRGPAREVMLLLQAANPNLSVADFLHAMKLVFGESESSVTAHSKFFNTLQAQGEKASLYVIRLEVQLQNAIQAGIIAQKDANQSRLHQFLLGAELNGDLRFRLKNLLRMYANEQERLPSFLELIRMIREEEDWDDIFIKQKRAKRSESVVARATRPVAFGGSPPIVIDNKDCNVIEIDDTPDDSDEDVILVGESQDLPRSFSDSPPSRRRARPQDQVLIIDSPNNSQFPSPCTSGGSGYKNDGPGNMRRTRKRKHTIRCSYCGEEGHSKETCDNESNKAQMFENLIITLQELAHTEERSREAPVEPSDPCELQ
The following text describes a protein:
Function:
May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing. Binds to poly(A)+ RNA. Appears to act in the maintenance of CLN3 mRNA levels.
Miscellaneous:
MISCELLANEOUS: Present with 5830 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSDENHNSDVQDIPSPELSVDSNSNENELMNNSSADDGIEFDAPEEEREAEREEENEEQHELEDVNDEEEEDKEEKGEENGEVINTEEEEEEEHQQKGGNDDDDDDNEEEEEEEEDDDDDDDDDDDDEEEEEEEEEEGNDNSSVGSDSAAEDGEDEEDKKDKTKDKEVELRRETLEKEQKDVDEAIKKITREENDNTHFPTNMENVNYDLLQKQVKYIMDSNMLNLPQFQHLPQEEKMSAILAMLNSNSDTALSVPPHDSTISTTASASATSGARSNDQRKPPLSDAQRRMRFPRADLSKPITEEEHDRYAAYLHGENKITEMHNIPPKSRLFIGNLPLKNVSKEDLFRIFSPYGHIMQINIKNAFGFIQFDNPQSVRDAIECESQEMNFGKKLILEVSSSNARPQFDHGDHGTNSSSTFISSAKRPFQTESGDMYNDDNGAGYKKSRRHTVSCNIFVKRTADRTYAIEVFNRFRDGTGLETDMIFLKPRMELGKLINDAAYNGVWGVVLVNKTHNVDVQTFYKGSQGETKFDEYISISADDAVAIFNNIKNNRNNSRPTDYRAMSHQQNIYGAPPLPVPNGPAVGPPPQTNYYQGYSMPPPQQQQQQPYGNYGMPPPSHDQGYGSQPPIPMNQSYGRYQTSIPPPPPQQQIPQGYGRYQAGPPPQPPSQTPMDQQQLLSAIQNLPPNVVSNLLSMAQQQQQQPHAQQQLVGLIQSMQGQAPQQQQQQLGGYSSMNSSSPPPMSTNYNGQNISAKPSAPPMSHQPPPPQQQQQQQQQQQQQQQQPAGNNVQSLLDSLAKLQK
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTASILGQFFPETLFFIPMNVFSMAFCLSWLVFIYPVNWAPSRFQSIWLGFRSNILEMIFQNTSPNTAPWAGLIAGVFVLILLVNVLGLFPPYAFQSPTSNISLTYSLGFPLWMAINILGFYLAFNSRLSHLVPQGTPSALIPLMVWIETLSLFAQPIALGLRLAANLTAGHLLIFLLSTAIWLLSSSLMISVPILIIFILLFVLEIGVACIQAYVFTALIHFYLQQNI
The following text describes a protein:
Function:
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Sequence:
MREGEKLWSRNSEGHSSDPEEDEEEMAFGDTEDDYEEMMDLSDLPTALFACSVHEAVFEDDRYRERFEALFRIYDDQTSFQMFKSFRRVRISFSTPEAAARARIELHESDFNGTKLKLYFAQVQNSGDDVDKAYLAPPQPVKQFLISPPASPPVGWSQSEDATPVINYDLLCAVAKLGPGEKYELHAGTESTPSVVVHVCESETEEEEEARPKAKIVQTRRPDGPPKIYN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSFQQRFARALDVGYKNFLSKDAVRNIFAYDNHLRGLVQKECKIHQTPYRVPSDLMVQSASDPARANLFNYSSQLVNHDFFFSGLISPERPSADADLGAINLKPGIDASFGSFGELKSQMVDVGNSVFGDGWLWLVYSPEKSLFSLLCTYNASNAFLWGTGFPKFRTNAIVPLLCVNLWQYAYLDDYGLNGKKMYITKWWDMINWTVVNNRFQATRIESL
The following text describes a protein:
Function:
Functions as a negative regulator of salt stress response. Functions as a repressor of WRKY8 transcription factor by decreasing the DNA-binding activity of WRKY8 and acts antagonistically with WRKY8 to regulate sodium and potassium homeostasis under salt stress.
Subcellular Localization:
Nucleus.
Sequence:
MDKSCNSSGDSSAVSASATSSTGNNTTNRDHYLRQLNKLSHKISKPTNSSSSVSVANREIDLPPPPPLQINQGNLHQHQPPVYNINKNDFRDVVQKLTGSPAHERISAPPQQPIHHPKPQQSSRLHRIRPPPLVHVINRPPGLLNDALIPQGSHHMNQNWTGVGFNLRPTAPLSPLPPLPPVHAAAESPVSSYMRYLQNSMFAIDSNRKEFSGLSPLAPLVSPRWYQQQENAPPSQHNSFPPPHPPPPSSAVSQTVPTSIPAPPLFGCSSSPKSPYGLLSPSILLSPSSGQLGFPVSPTTVPLPSPKYKGH
The following text describes a protein:
Function:
Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein.
Sequence:
MKRSTTVPTSVHSLRPADIDIVAAMGDSLTAGNGAGAEGDDELAVAIQFRDILKKFNPNLLGYSVRTGSANVWETAHLNAGVPGAHSEDMPQQAGDLARRMREHPELDYLNHWKLVHIFIGINDICRFCFTDNEDGDHYVENVRQGVQYLKENLPRTIVILSGMYDASLLRRLDHSGPFCKPTPYPMGRLMLFFLCIVGNYLIRFECKCEQNATVTDAELHDISRDYMGKMWSLQDSGEFESDDFTLIIQPYLEHAEDVGRNPDGTPNMDFFAPDCFHFSAYGHAILARNLWNNMMQSVGAKTAANLTDNGESLLCPDKACPFIRTTKNSEDCTKYNN
The following text describes a protein:
Function:
Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.
Miscellaneous:
MISCELLANEOUS: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).
Subcellular Localization:
Nucleus.
Sequence:
MPVAPHELRDTIKSRDLGLFQCIDLLKQHNDNIGVHHQLVQKLYSYSYDELEFFIPQFIQLLVNFETDSMALEDFLLHYCNQFPHFSLIVFWYLQAFLFELRNEPKSYSFQTVRKFINKLQNILFNVETSFHIRGPEFRENMQPALILCGSVASAFSSPLVNEYALPIVRSQGKQQKSFVFKLASFQKSLTRNLTMKNQRLSADAITPVISDDDSKVSNRIQESQRLKTKYSKKKISAALQLDDSENYTTDEEELGYVQTLSRPKIREMKYTEVEENLKINTIIRSKKNRSKTTVNSISFFSDTDQSASMEEYNRSAQSLPELVRTRSRLDLYSSESEAALGTSRNSAELIISKKKFMGSEVKTRPYKELLKILQVNYSKKETSFIMSLQNISLRLSSVPKVARLSALRAELSIINESILPSEIDIPQLLPVTSNKNKKFHKILKLNINEACVLNSAERVPYLLLIEYLSDEIDFNPFSDQNQKIINDCVRKPEVKPNDQISGDDDTSVVSSIQEEMFLDNNASENYNEDGDLGEISLLHSRSSSRDWAKSTPGSPVARSSQEDEKFYGNVSSTTGGTIESSVLADQMRIASLMLQQLESSGQSNTQQFVSIRNRIIESMISLQDQFDFIDYETLKELKTDEQDAGKRKLENDFKLAEDWNEKKHRIRKSSIYGHLENWDLCSVIVKNGDDLPQEAFACQLISLISNIWKKHKVDFWTKRMKILITSANAGLVETITNAMSIHSIKKSLTELSIENGENAKGRIFTLKDYFQKLYGSVDSSKYVKAQENFAISLASYSIICYVLQIKDRHNGNIMLDHEGHIIHIDFGFLLSNSPGSVGFEAAPFKLTSEYVEVLGGLESKAYLKFVDTCKNCFKALRKEWGQIVSIVELMQKGSSLPCFNNGDNTSVLLQQRLQLHLSDEEIDSFIEVYLIEKSVGSMYTRLYDQFQMITQGIYS
The following text describes a protein:
Function:
Part of the PpsABCDE complex involved in the biosynthesis of the lipid core common to phthiocerols and phenolphthiocerols by successive additions of malonyl-CoA or methylmalonyl-CoA extender units. PpsA can accept as substrate the activated forms of either icosanoyl (C20), docosanoyl (C22) or lignoceroyl (C24) groups from FadD26, or a (4-hydroxyphenyl)-C17 or (4-hydroxyphenyl)-C19 fatty acyl from FadD29. PpsA initiates the biosynthesis and extends its substrate using a malonyl-CoA extender unit. The PpsB and PpsC proteins add the second and third malonyl-CoA extender units. PpsD adds an (R)-methylmalonyl unit and PpsE adds a second (R)-methylmalonyl unit. The incorporation of the methylmalonyl units results in formation of two branched methyl groups in the elongated product.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQELRDAGVSDKTLADPAYVRRAPLLDGIDEFDAGFFGFPPLAAQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVYGTSSPSGYLLHNLLSHRDPNAVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYFTSPGSMVSAVGHCRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGSAINNDGSAKMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQGLRAAFEVSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALPATLHYTSPNPELRLDQSPFVVQSKYGPWECDGVRRAGVSSFGVGGTNAHVVLEEAPAEASEVSAHAEPAGPQVILLSAQTAAALGESRTALAAALETQDGPRLSDVAYTLARRRKHNVTMAAVVHDREHAATVLRAAEHDNVFVGEAAHDGEHGDRADAAPTSDRVVFLFPGQGAQHVGMAKGLYDTEPVFAQHFDTCAAGFRDETGIDLHAEVFDGTATDLERIDRSQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYIAATLAGVFDLQTAIKTVSLRARLMHESPPGAMVAVALGPDDVTQYLPPEVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSAMDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISSPIRFADELDVVLAAPSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRLMRHPLQDVDDRDTFLRALGELWSAGVEVDWTPRRPAVPHLVSLPGYPFARQRHWVEPNHTVWAQAPGANNGSPAGTADGSTAATVDAARNGESQTEVTLQRIWSQCLGVSSVDRNANFFDLGGDSLMAISIAMAAANEGLTITPQDLYEYPTLASLTAAVDASFASSGLAKPPEAQANPAVPPNVTYFLDRGLRDTGRCRVPLILRLDPKIGLPDIRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEFTGLSNRSVPNGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAAHGGPHYLCLAIHAMVTDDSSRQILATDIVTAFGQRLAGEEITLEPVSTGWREWSLRCAALATHPAALDTRSYWIENSTKATLWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRRRFRRSIQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLRPDVDLRRTVGWFTTYYPVPLACATGLGALAQLDAVHNTLKSVPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSGDAPVQFDSDMTLPVREPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPAATAEALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMDAG
The following text describes a protein:
Function:
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Subcellular Localization:
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MKLNERNVVYYATSKSPVDKRGYLFKKGDRNTSYNKRWFVLKGNTLFYFDNEESREPLGVIILEGCRVELCESSEEFAFAIKFEFTKSRAYILAADNQITMESWVKSLSRANFEYIRLVVVELQQQLKEMKTSTTSYKIQGVTEKDKQLSCNAHQFLSQDLHEKTACCVQKDHIDATGNHIPVAVANGSVCNCEEKDLRCLRSSLKGSSLPDSLSMQTQVIPKTDEDDMCLSTKGGAESPTFSSFEKLHDFFGEEIVALRAKWIEVLQKQL
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Signal transducer of the phototropic response and photo-induced movements. Involved in the phot1 pathway under low blue light (LBL) fluence rate and in the phot2 pathway under higher fluence rate of blue light (HBL). Necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Not involved in chloroplast accumulation and translocation.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MMWESESDGGVGVGGGGGREYGDGVLSSNKHGGVKTDGFELRGQSWFVATDIPSDLLVKIGDMNFHLHKYPLLSRSGKMNRLIYESRDPDPTILILDDLPGGPEAFELASKFCYGVPVDLTATNISGLRCAAEYLEMTEDLEEGNLIFKTEAFLSYVVLSSWRDSILVLKSCEKLSPWAENLQIVRRCSESIAWKACSNPKGIRWAYTGKAPSPSTTNFAGSSPRWNESKDSSFYCSPSRNTNSQPVPPDWWFEDVSILRIDHFVRVITAIKVKGMRFELLGAVIMHYAGKWLPGLIKEGGVAIAPAMSSAIGGGLGLGGDEMSISCGSNSSGGSSGPDWKGGLHMVLSAGKTNGHQDSVACLAGLGISPKDQRMIVESLISIIPPQKDSVTCSFLLRLLRAANMLKVAPALITELEKRVGMQFEQATLQDLLIPGYNNKGETMYDVDLVQRLLEHFLVQEQTEGSSPSRMSPSPSQSMYADIPRGNNNNGGGGGGNNQNAKMRVARLVDSYLTEVARDRNLPLTKFQVLAEALPESARTCDDGLYRAIDSYLKAHPTLSEHERKRLCRVMDCQKLSMDACMHAAQNERLPLRVVVQVLFSEQVKISNALANTSLKESTTLGEAMGTYQPMIPNRKTLIEATPQSFQEGWAAAKKDINTLKFELETVKTKYVELQNEMEVMQRQFEKTGKVKNTPSSSAWTSGWKKLSKLTKMSGQESHDISSGGEQAGVDHPPPRKPRRWRNSIS
The following text describes a protein:
Function:
Involved in the transport of siderophore iron and so has a role in iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRLKSFSTTLDTLRRRFNDSSSEEDKLEKNIQDETSIKEVSLQDAKQSDEKGVEEKVFNDESFSIDVAPKPEDELSGIVKARYLTEHSSRISFYICYFSIFLLFFAISFQAECYYSLTAYATSAFAGHSLLSTIAVANNIISAAIKPPLARLSDVFGRLEAFLFSLLLYLVGLILMAASTNVQTYAGGSVLYNAGYTGVELIMTIFMADTSSMANRSLVLGISYLPFVVTIWIGPRVAQEFYMHSTWRWGIAVWTILIPACSIPFLAVYSYYQFRAWREGALKGTLTINPVELFKKLDIIGLILMTAGLALVLLSISLASYDTGKWSDAKFIVMIIIGGLCLIAFVLYEIFVASFPALPFRLMREPTIGACCAMSFLFYITFYCWDNYYYSFLQVVHYTSITAAGYISYTYSFTSCATGFFLGILIRLTKRYKWYFVASIPVYILGQGLMIRYRGEQYNWGYQIMPQIIVGIGGGVIANLLTVAVQTVVSTENFAIVTALVSTVTPIGGAVGSAISGAIWNSVMPKRLEKNLPSDLKDQAYTIFESLTVQLSYTRGTDARNAIILSYSEVQKILTSVATGFAGAMIFPVWFVANPRLSTVKTHIFDSKESKV
The following text describes a protein:
Function:
Post-meiotically transcribed gene that has a role in late spermiogenesis; required for actin cone progression during spermatid individualization.
Sequence:
MDPRLYRLIRFPSNGLGNNNNDPNQQRGERPRQPHPDLGWILDAPNEPPRNRNPLLYLVTAPPRPRKKRSFMTTSKPFRIQTNVSDLQYNAWQAIQDAPPEKRCEYYVKYMDEHMNSQNYPNGVGLPHRWGQF
The following text describes a protein:
Function:
Plays a role in negatively regulating the permeability of cells to small molecules.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Domain:
The C-terminal region is required for localization to tight junctions which occurs in a TJP1/ZO1-independent manner.
Sequence:
MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA
The following text describes a protein:
Function:
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MNRQDLAVPLRLLGVSLLVFGLLYQGSLMAIGDAVFPNSSAGSPVYVDGQEQPVGSQMIGQQFRPGQPEDVQYFWSRPSANDYNAMTSASTNWGPTNPLLSERVRADLQNISQYETPDDSVPVNLVSESGSSYDAHISPAAAEYQVLRVANQTGISEQRLNEMIDEATKEPWLGIWGHERVNVLELNLMVRDALNEQNETDQNSDMNASEIANGDH