lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
CD-NTase priming component of a CBASS antiviral system. CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophages. The CD-NTase protein (DncV) synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type II-A(GA) CBASS system; Primes DncV; acts as a protein transferase, conjugating DncV, the CD-NTase, to unidentified target(s) in the cell via an E1-E2 ubiquitin transferase-like mechanism. During the conjugation reaction DncV is probably transiently attached to AMP (Probable). Protein conjugation requires ATP (By similarity); Protects E.coli against phage infection. When the CBASS operon (capV-dncV-cap2-cap3) is introduced in E.coli MG1655 there is about 100-fold protection against phages P1 and T2. When the operon is introduced in E.coli MG1655 there is a more than 10(3) decrease in the efficiency of T2 plaque formation. Protects 100-fold against phage T5, offers no protection against T7. When the operon is introduced in E.coli MG1655 it protects against phages T2, T4, T5 and T6. Another paper shows the operon confers protection against phages P1, T2, T5 and T6 but not T4 or lambda.
Domain:
Has an N-terminal E2-like domain, a linker and a C-terminal adenylation plus E1-like domain, dimerizes via the E1-like domain.
Sequence:
MKQELHHTLLGCGFRYTPAKQMPKGILLDTKSRRKGYYVKEYSTKGGVFVIALVLWNDPHIQLPFAYILQQPEQYKGRLLPHINFGFCLCYVTQMEADWNSNDLKSTYQDVDEQIQLTLDNSVASVESGTSNDVELEGEFSAYWQSEEELYLLAKPSRKAQLKAHLVEAELSSGSIRREYVAACSEQSEELVKWLNQRKFDESSLQEVSITTHCISVKPNRLAGVNWPPSCLREVLSWLKLVDYSAHARTVTLLMAKRTKRHILLFDVEGQDELAVYLELNLDVIGKRYFGRNAARKRNINNEAALLGGKFVSANFKRLGVTRADRDTLLSRNQSRPDVGNLSQKRIALIGCGTIGGYLAELLLRSGAGCGENYFHLYDNDSFKPHNFARHSLTAHNFGLAKSIALANSLKEAVHIAQSIKGIDRQFPIQADVLSKYDIVIDATGRPPVSKRLAAVARTLIADIRPVLIHAFNDGNGRASKVLVDDGRCCYGCMMADPAVYRNNIDLRFEGIDLAKEKHISCGSTYTPYDAAVSHITAALAQEAVLNTLEHTLPWNYSEHMLDGSRSKKPRTLKRFSGCNICDE
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.
Miscellaneous:
MISCELLANEOUS: Present with 6120 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Sequence:
MDYEDNLEAPVWDELNHEGDKTQSLVSNSIESIGQISTNEERKDNELLETTASFADKIDLDSAPEWKDPGLSVAGNPQLEEHDNSKADDLINSLAPEQDPIADLKNSTTQFIATRESGGALFTGNANSPLVFDDTIYDANTSPNTSKSISGRRSGKPRILFDSARAQRNSKRNHSLKAKRTTASDDTIKTPFTDPLKKAEKENEFVEEPLDDRNERRENNEGKFTASVEKNILEQVDRPLYNLPQTGANISSPAEVEENSEKFGKTKIGSKVPPTEKAVAFKVEVKDPVKVGELTSIHVEYTVISESSLLELKYAQVSRRYRDFRWLYRQLQNNHWGKVIPPPPEKQSVGSFKENFIENRRFQMESMLKKICQDPVLQKDKDFLLFLTSDDFSSESKKRAFLTGSGAINDSNDLSEVRISEIQLLGAEDAAEVLKNGGIDAESHKGFMSISFSSLPKYNEADEFFIEKKQKIDELEDNLKKLSKSLEMVDTSRNTLAASTEEFSSMVETLASLNVSEPNSELLNNFADVHKSIKSSLERSSLQETLTMGVMLDDYIRSLASVKAIFNQRSKLGYFLVVIENDMNKKHSQLGKLGQNIHSEKFREMRKEFQTLERRYNLTKKQWQAVGDKIKDEFQGFSTDKIREFRNGMEISLEAAIESQKECIELWETFYQTNL
The following text describes a protein:
Function:
Plays a role in the inhibition of host immune repsonse by counteracting the action of interferons on early events in the viral replication cycle.
Sequence:
MVNDKILYDSCKTFNIDASSAQSLIESGANPLYEYDGETPLKAYVTKKNNNIKNDVVILLLSSVDYKNINDFDIFEYLCSDNIDIDLLKLLISKGIEINSIKNGINIVEKYATTSNPNVDVFKLLLDKGIPTCSNIQYGYKIKIEQIRRAGEYYNWDDELDDYDYDYTTDYDDRMGKTVLYYYIITRSQDGYATSLDVINYLISHKKEMRYYTYREHTTLYYYLDKCDIKREIFDALFDSNYSGHELMNILSNYLRKQFRKKNHKIDNYIVDQLLFDRDTFYILELCNSLRNNILISTILKRYTDSIQDLLLEYVSYHTVYINVIKCMIDEGATLYRFKHINKYFQKFGNRDPKVVEYILKNGNLVVDNDNDDNLINIMPLFPTFSMRELDVLSILKLCKPYIDDINKIDKHGCSILYHCIKSHSVSLVEWLIDNGADINIITKYGFTCITICVILADKYIPEIAELYIKILEIILSKLPTIECIKKTVDYLDDHRYLFIGGNNKSLLKICIKYFILVDYKYTCSMYPSYIEFITDCEKEIADMRQIKINGTDMLTVMYMLNKPTKKRYVNNPIFTDWANKQYKFYNQIIYNANKLIEQSKKIDDMIEEVSIDDNRLSTLPLEIRHLIFSYAFL
The following text describes a protein:
Function:
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLHDEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN
The following text describes a protein:
Function:
Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.
Sequence:
MTSVFIRNFTFAALPANGLNGQPPFHGLLAKCDFEVNEYRDELFAAYGIPFPGSLNKAVIKRRAEYLAGRFVARQVLNLLDIRDYPLATGMDRAPQWPTNLIGSISHNNQRALCAAQMIEPRGVESSTLHGIGLDIESHIAEEKAQEIWSGIISDEEYSLLQQGPLPFNQALTLVFSAKESLFKAVYPQSGRYFDFIEARLLSYSLVSGNFELQLLRHLNDEFPAGRCFSGCFSLSETDLQTFIAY
The following text describes a protein:
Function:
Transcription activator that acts as a flowering master switch in both long and short days, independently of the circadian clock. Promotes flowering upstream of HD1 by up-regulating FTL1, FTL4, FTL5, FTL6, EHD1, HD3A and RFT1. Seems to repress FTL11 expression. May recognize the consensus motif 5'-TTTGTCGTAAT-3' in target gene promoters.
Sequence:
MLKSALSSLRVHSQHQKLSYQTMSQTSEEESLFNFQQQQKLALCEAALSKGDPIIHAGKKRRGHPGQPDPDAEVVAFSPKTLLATNRYICEVCHKGFQRDQNLQLHRRCHNLPWKLKQTSGTDAKKKVYICPEATCPHHDATRALGDLTGIKKHYSRKHGEKKWKCERCSKKYAVQSDWRAHTKICGTKEYRCDCGTIFSRKDSFITHRAFCDALTEDNSRINQSLAAMVGSLHGQQQNIFPHTIPGPDSSPNDAAGNFSGNDHSSDDHLGSLSPYTFIRRSTSLFSNQMILPHDSGTLADGSEPSSPYMSMSSPYMSATALLQKAAEMGAKTSEDPTTPLLLKGFPNYFTTKDHIGISSGILGTPIANSDRKKTAEDNSSYMNSPWTGSCMRLPNAVPWIGLPPFSMGAENRSSSMVDEDHMQQNAHETIFGVRDVGLTQDFLGLGGHGNAEMHDDTYNGEMALSYSNEQQKSEQDIYSYHQ
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MFHNVLAMVPNQATRHARRVYVGGLPPTANEQSVATFFSQVMSAVGGNTAGPGDAVVNVYINHEKKFAFVEMRSVEEASNAMALDGIILEGVPVKVKRPTDYNPSLAAALGPSQPNPNLNLAAVGFSSGSTGGLEGPDRLFVGGVPYYLTEDQIRELLESFGPLRGFNLVKDRETGNSMGYAFCVFQDPSVTDIACAALNGIKMGNKTLTVRRAVQGVRKQVFTYSTT
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MRSDRVRDAGPGRILAVSPARRRTDEVGPMSTGAENTENTARTPGRLTALLVDASTRAVGAAGGRVGGVYLRSATPGLLRLAVLSGLPGPLFRPWWRLHADSPFPVADAYRLGVRVVLPNAAETMRRYPQFAAGLPFPFGSLYVPVAGASRTYGVLTVLRLPAPDAADMLEGADLVAGLAQDLGAALERLDADGDAPPVAWEGEPLCVRPPASGRHPQLAGSFGWDPDTGAVTLDEPLCVLLGLPSSAAGTPAALGRLTGVMAPDDGHRIAAALRDTAAGRPPRLPLYVRTAEGSPRLVELWRPRPAPPGGGPVRGAVRDPFAGTVADAAADLLPEGVFCVDRLGTVVYANPRAVRLLSSPRARLLGRSLWEAVPWLDQAAYEDHLRGALLSPDPVRFHVRRPPDASRRAAPRPYEGDWLAVSVYPGPDFLTLTLRPANRVADASAGLTPEHGAPEDAPGPEAGDPAPPVTTTAPEYRPIVLAVALTEAVTARQVSEVVVRELLSAFGGRRLAIYLLQDRHLHLAWETGFPPGFLAPFEGVPLDARLPGVETLTSGRPLFFDSMRALASAYPGIPLDAAEGARAFLPLIASGRPVGSCILGFERSRGFSTEERTVLTALAGLIAHAMEKARRYESETALARGLQEVLLPRRLPAHPLLETAGRYLPGTQGLDVGGDWYDVVASGDGMALVIGDVQGHGVQAAATMGQLRSAVRAFALGDRPPDEVMSGVNHLLADLDPGLFASCCYIRLDPATGRACAARAGHPPPLLRHPDGRTETLDLPGGVVLGVDPGAPYPLTEFAIEPGAVLALYTDGLVERPGTDIDEGITALRLALARAGAPAARPGSRSLAGVADRIVVSARHTADRPDDIALLLATRRARSGSPR
The following text describes a protein:
Function:
Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLHPTRPTTQHLIKLRLFVSLAMANSFTLLADIKACRCSTTAEVRLLRFWEAPNVKRGSKLMGVDMLLIDEQSTLMEGSLSVNLLSIFIERFSEGSVYTMCEFEETIDDIDYKRKVQVQVQDLGTDVKFRDDEIKEPGFIGKKREVDYVNTYPEGPINMEVVTIVLMMLYTWRESSSIQGISDGISDGISDVQMPTINHPHLWYLEAVRLASTKPVDGLNENGEKAPLVTTLAPLSSDSLQQLNIDFNFDFYGFSDERRRDFRSSPLKIHTPQKGPPSESQSIPRYCERFNLFLLFRTRLSSGGDVSEIGPVAAIRMPMLRVSDFKGGTPELIQTCYAILVCVLPSGQPRDWSYQEIEIVKVVADQVAVALSHAAVLEESQMMRDKLADQNRALQIAKRDAMRASQARNVLQKAMSEGMRRPMHSILGLLSMIQDEKLSNEQKMIVDTMVKTGNVMSNLVGDAMDVSDGRFVTEMKPFSLHRTVREAACLARCLCLYNGFRFTVDAEMSLPDNVVGDERRVFQVILHMVGSLVKPRKCREGSLSSSVIFKVFKERGSLDRSDQRWAAWRSPTCSADGVYIRFEMSVENDGSSSQSFASVSSRDQEVGEVRLSGYGLGQDLSFGVCKKVVQLIQGNISVVPGSDGSPETMSLLLKFRRRPSISVHGTGEAPAPDHQPHPHASYLLRGLQVLLVDTNDSNRAVTRKLLEKLGCIVTAVSSGFDCLTAIAPSSSSSSSTFQVVVLDLQMAEMDGYEVAMRIRSRSWPLIVAMTVSLDEEMWDKCMQIGINGVVKKPVMLRAMESELRRVLLQADQLL
The following text describes a protein:
Function:
Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL10 and CXCL11.
Subcellular Localization:
Secreted.
Sequence:
MTSHGAVKIAIFAVIALHSIFECLSKPQILQRTDHSTDSDWDPQMCPETCNPSKNISCSSECLCVTLGGGDETGTCFNMSGVDWLGHAQASDGHNDG
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MNAYILLSLATLTLLYQECLGANWHYHQHGPLGPENWPTIPGSHCGGRKQSPINIESRSVIQADLGEFVFEGLQTTYGTQVGAGGNQAGQGGGQGGQGGSGFNWGGAGAGGGGGGVGGVGGGGGWNWNSWWNGNGWGGNNGGGQNAVGNQHPQWSNPFGNLQMGPKPTVNPYQPFGMNGPERMFTTDNNQNAYAPRALHGYNSAPTTKVEVSNDGHTLKVSTEGMYVLKGGGLPFDAKPAQLHFHWGTTPERGSEHTIDGRPFSAELHLVHYNAKYRTIAEAVKQPDGLAVLGFFIQDSGSYENPAFDPLLDITENVKFKDTKVEYYAHLPLRDMLPTDLSCFYRYNGSLTVPKCWESVTWSVGCGVIHLSHNQLDMFRELYQGFFMEPNGQLEMLHIEDNFRPVQPLFDRQVIRSGFPSRAGMGYSANNSANLISVNLFLLLSAIMAFVCRSL
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Subcellular Localization:
Cytoplasm.
Sequence:
MARHPYRRLRPAKSGFPEVGISEEGNIRSLHLGSDTVQSSMNLDHPSELVLSYSRAMMGWLLFTDALPQHITQIGLGGGSFARWIDTYLPDTRQTAVDINPQVIAIARNLFELPFEGEKFEIIEADGAEYIKVFRHNTDVILVDGFDGEQIIDALVEEPFFRDCRNALSSDGIFVTNWWSGDKRYQRFIERLLSVFEGRVLELPAESHGNVAVMAFQSSPKEQNIDKLKKRADKLSNAYGLDFHRMLAGLKASNPNNGKHFHL
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSRVISKVTTYFKQHSTAEWKHYFLSTHFWGPVANWGLPLAALGDLKKNPDMISGPMTSALLIYSSVFMRFAWHVQPRNLLLFACHLANFSAQGAQVNLFICFLFLSVLAKTFQLGRFINHNYLHYVEDPVHHKLMVKKEILEHEHEIEIKKAH
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MTKEANDIFASCSFDSLGLDSSLCQQLRERMSFQVPTLVQSQAIPFILSGRHVLVNAATGTGKTIAYLAPIIHHLQRYNPRIERSDGTFALVLVPTRELCMQVYEILQKLLHRFHWIVPGYIMGGENRSKEKARLRKGISILVATPGRLLDHLKNTSSFLRTNLRWLIFDEADRILELGFGKEIEEILDLLGSRQSMSACKEKVMSRFSEFQRQNLLLSATLNEKVNCLAHISLENPVTVGLEEKKVFIEQQTTLSKQFRSPGSDVDDESEQPDRHLNSLNGDYSLPTQLVQRYVKVPCGSRLVVLISILKDLFEREASQKIVVFFSTCDGVDFHYSLLRDFKWPSKLQPELVQKQMFVRCRTFRLHGNMDHEDRRTTFQGFKAEKSALLFCTDVAARGLDFPKVRCIIQYDSPGESTEYVHRVGRTARLGERGDSLLFLQPVEMDYLQDLQKHGVLLNEYLLLKILNSFPLYDQKHHVNKFVSVETHPWVLFLQKALESFILAESGLKKLAKDAFCSWVRAYAAHRGDLKRIFMVKKLHLGHVARSFGLKEQPSLVGRSFQVHTKKRKKDQKQKGMTKKRRVAGKT
The following text describes a protein:
Function:
May play a role in the regulation of membrane traffic through the trans-Golgi network.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MIPARPWSALSPVQALVEQTCDPTLPVPNDIANIELAELINRKKANSAREATTALLPHINSRNPNEALLALNVLDYLVKNCGYPIHLQISTKEFLNELVRRFPERPPMVIGRVMGKILDLIHEWKNTLCVTSKYKEDLVHIRDMHRLLSYKGYRFKQFDAARALASANPNENLKSPEELEEEDRAAKSAKLQELIRRGTPRDLAAAQELMKALAGAEPEKAVDYTAQTLKELDKVQAKAILLNDMLNNATQGEKIGIEGDVYDQVAGACRGARPRIQKWIEDDNGEREGMMDRLLLCNDLINTALERFEACKAGDWTKAQAVVERNNPNQKVADLISFDVFDNEPASSSSGGVTLPADNIPSTSNVGMTTSGLPLDLFAPSPVATPSPAGSSTVGAAGQKQKQDPMAFFSTASPQPQATQQWGQAQAQPTSAFGGLGGLQQPTPNTNNNNFAFGGFQSSQSSSPAVGYSLSPQPAALSSQQFIQPQQPQQSQPQQQPQQQQQQQTKKDAFADLVDLMS
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents YafO-mediated cessation of cell growth and inhibition of cell proliferation.
Sequence:
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRAEQYLNDMTDDDFNDFKE
The following text describes a protein:
Function:
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. May be involved in Golgi homeostasis.
Subcellular Localization:
Endosome. Lysosome. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle, COPI-coated vesicle. Endoplasmic reticulum.
Sequence:
MRVDENLRLDEQLLLFMEQLEALEEKRQRLNSLIEEGWFSIAKARYSMGNKQVSALQYASEMQPLAHVETSLLEGGTAEFKCERSENKAEEQKTKTIEDIGAKETGLRRRVHTKQKEVKEGEQDTDEVKTKTDSPTPEHRNPLKWFGILVPQNLKQAQSAFKEVITLSVEIASLQSTILATRKEMQVQMKEKQERTEKAQLEVKEE
The following text describes a protein:
Function:
Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe-S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor.
Sequence:
MTVSSHRLELLSPARDAAIAREAILHGADAVYIGGPGFGARHNASNSLKDIAELVPFAHRYGAKIFVTLNTILHDDELEPAQRLITDLYQTGVDALIVQDMGILELDIPPIELHASTQCDIRTVEKAKFLSDVGFTQIVLARELNLDQIRAIHQATDATIEFFIHGALCVAYSGQCYISHAQTGRSANRGDCSQACRLPYTLKDDQGRVVSYEKHLLSMKDNDQTANLGALIDAGVRSFKIEGRYKDMSYVKNITAHYRQMLDAIIEERGDLARASSGRTEHFFVPSTEKTFHRGSTDYFVNARKGDIGAFDSPKFIGLPVGEVVKVAKDHLDVAVTEPLANGDGLNVLIKREVVGFRANTVEKTGENQYRVWPNEMPADLHKIRPHHPLNRNLDHNWQQALTKTSSERRVAVDIELGGWQEQLILTLTSEEGVSITHTLDGQFDEANNAEKAMNNLKDGLAKLGQTLYYARDVQINLPGALFVPNSLLNQFRREAADMLDAARLASYQRGSRKPVADPAPVYPQTHLSFLANVYNQKAREFYHRYGVQLIDAAYEAHEEKGEVPVMITKHCLRFAFNLCPKQAKGNIKSWKATPMQLVNGDEVLTLKFDCRPCEMHVIGKIKNHILKMPLPGSVVASVSPDELLKTLPKRKG
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MASSGAVPFWRAAGMTYITYSNICANLLRNCLKEPYKAESLSREKLHFVLSKWVDAKPEKPTIRSDTPEQ
The following text describes a protein:
Function:
Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized primarily at the cell surface but also found in a perinuclear compartment in HC11 cells. In mammary epithelial cell, localized primary to the apical membrane.
Sequence:
MSQLLVAKVLCMVGVFFFMLLGSLLPVKVIEADFEKAHRSKKVLSLCNTFGGGVFLATCFNALLPAVRDKLQQVLSLGHISTDYPLAETLMMVGFFLTVFVEQLVLTFRRERPPFIDLETFNAGSDAGSDSEYESPFVGVGGRNHGLYPEPTAHSHGTGLRLRELGRPGPLRLLSLVFALSAHSVFEGLALGLQEEGERVVSLFVGVAVHETLVAVALGISMARSAVPLRDAAKLAVTVSAMIPVGIGLGLGIESARSVASSVASALLQGLAGGTFLFVTFLEILAKELEERSEQLLKVLFLVLGYAVLAGMVFLKW
The following text describes a protein:
Function:
Secreted protein that acts as a virulence factor during infections.
Subcellular Localization:
Secreted.
Sequence:
MKQNYILSIILCYLLANVHSAPAIITVWQTVTDAQVAAGPTAAAPAANANANVQQAAAASAPAPAPVASPAAPAPASSAPQSSTPSSSGWLSNLFNSFFGGSDSDSSSGSDTASAAPASTSPQSSSSSSSSSGNSFLSFLSGLFGSGSSSSTPSSISQQQQQQQGSPASGSNSPNSAQPDAAAASNPVPQSNNNQGSGLGSGFGSGFGSGSGSDSDSGSGLPSASSSTIIQQQPSSSNIGSSSTSSSSSSSSSSSSSSSSSGDIYAAISQCDGIDASFASEILDAHNKYRAQHKVGDLSWDVDTYNYAKNNADNYDCSGVLTHTHGKFGENLAAGFKDGASTVAAWVDEPISYSDASFVYNHFTQVIWKGSTKVGCAYKDCRKSNWGLYVVCEYDPYGNVIGQGSKNVFP
The following text describes a protein:
Function:
Transcription factor involved in monocyte-to-macrophage differentiation. Forms a complex with NPM1 to translocate to the nucleus, acting as a transcription factor that promotes the expression of the genes involved in macrophage differentiation, such as STAT3, STAT1 and JUNB.
Subcellular Localization:
Nucleus.
Sequence:
MEALQRQQAARLAQRVGPLAPPRPPPPPPPRPSFPGTRTLQAPEGGLGKVGAEEEEDAQEDEEGEEAGPEDEAAEGESHPGTQDTSSPSSQPPGPHPHEWTYEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSAAFTLRTQYMKYLYPYECETQALSSPGELQAAIDSNRREGRRQAYNATPLFGLAGPPPRGTPGPALGPGPAPPSATPTPAPRSAQGSASGLPAHACAQLSPSPVKKEESGIPTPRLALPVGLAFGPAREKVAPEEPPEKRAVLMGPMDPPRHGAPPSFLSRGKIPLREERLDGPLNLAGSGISSINMALEINGVVYTGVLFARRQTVPASQGPTNPAPPPPTGPPSSTSP
The following text describes a protein:
Function:
Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MDFLMSGVAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFFTIGKVDGLAALQKGLGPALLYQFLMNGIRLGTYGLAESRGYLHTNEGTHSPVRSAAAGALAGVMGAYLGSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGAVGGLPRVVIGSSTQLCTFSSIKDLLSQWEIFPPQSWKVALAAAMVSGVAIVVAMTPFDVASTRLYNQPTDTRGKGLMYRGILDALLQTARTEGFFGMYKGIGASYFRLGPHTILSLFFWDQLRSFYNTYAK
The following text describes a protein:
Function:
Required for protein secretion. May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier. At basal transitional ER sites in follicle epithelial cells, mediates the exit of basal membrane protein such as vkg, LanB1 and Trol, from the endoplasmic reticulum (ER) to basal Golgi clusters.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network.
Sequence:
MRLTNEKATMQPQLSDLALVLGLLICCLPTLTWAATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLISFKINSPIRVLSKSAGSNMQLWGVDINGRRGYANKDFIMEKKILVRDKDLLYEVPVVGPGSPVQSVETPVQSVETTVQPVLNASESTDDLATTTTSPLEIAVDSIVVEHDKLQDQQVPDPTAASKAQVQVIEGTELPLEAIAATTEGSIVPETAADPQEATNLDSTVVDTKEPQALNSEAIKLQEEPKAQQPATEAEKPPPLPQAINAELEDADDFDYGDDETDDDSQQGSQDNESIVEIANDNKSINESIELKPLSVAQLKKTDKVEDSKDETKEKHAEMEVSKQEDSSLPTETLNVTALEEQIDQKEFPKQVLDAAVELKSSDPLPVEEVTETVAEPPRTIVEDKINEEIVPVSAKIQAKPATVNPTEPIVAQSDAEIKAPSESVISSTTPAPVVEEAPQKADPVGLPPLFEKKNFENPNNYYKQLQEEQEKQRLVAEAEEQKRLQEEADQQKRLQEEAALNKRLLEEAEQQKRLQEEAEQQKRLQEEAELNKRLLEEAEKQKRLHEESEQLQRSSEEAEPQLSVQEANMQQLNDSVDSQSNEIVDNNNRQQPEQYQQHHHHTESAFNHPSTASHTTPTPDAESPYAAVQEETTEASQTDNHREGVGYVEPVALPATASPVSEVPIKEDAAGFGLFATIVDTVNNFIGKDPQSDPADSSDELHRILYPGRPEVPPSQRKAEDFAPADVDGYCARFQAKDEHCHRSISLDNFVEVMADKLVDHSQLLLCVVIAAISSLFFMFAYYCFCNSSQEGALLSKLNHLERSLLASHKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEKAKLQEQVGSLERDLDNAAEAGLELNKMLSEVLNGQNGDEAFMSTVDELQRQLNDQEKIIIEINNSLAEKSRENSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESELAKALEARNYEMQKLQNQIVELTVKWEREHGDLQTSLAKIEALEDCLKAVGKDAIHNVQELITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTMASGGGGVGGDPGVMEAIAANGTSVLGAELKTAPSPLPLPGSPLLNMPNPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGRMRSPPPSSRGDRDRERYSDYSDYDDYDDDEEDDRGMDRRRRHSGSWGRRHRGSYSHSPRTYRSLSPSDSRYNYNDTETDFSPPPSPPPVPSGRSATSRPYSEV
The following text describes a protein:
Function:
Protein kinase that positively regulates proper entry into stationary phase of cells under nutrient starvation conditions. Involved in glycogen and trehalose accumulation, derepression of stress-induced genes, induction of thermotolerance and starvation resistance, and proper G1 cell cycle arrest. Also involved in the activation of a meiotic genes activation pathway. Phosphorylates IGO1 and IGO2, both involved in the TORC1 control of gene expression and chronological life span.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFNRSNTAGGSQAMKEGLGINKLSPISSNSNPSSLTSSNYEKYLQLATEKNPCMILELELDGKVRYGSPQWNTITGVADDSGSSPTYIADLILGSDQDKGVFQKATDMLLMNDDTSCTITFKIKAADYEGSAGCDDESTITTLEARGILIRDGHTQLPSHTMWIVKPRTNDWSDFYANEDAQDDMVIQLSDNCDDIDIQLPEEFAKTLGFGAKIFVQYLKRIRLEMIIDEFNLPLPKMELCRVCENFVPVWWLETHSQSCVCEHRTESLIQLLHDNLLEQQAILANFTKDSEYKGSQIQVRSNNFLNQVLDSLRELCQDAIDINPSEMVPDLYHSLSTFPQDNGNNNNNNNNNNNNNNALLDQFPIQKDTVSLNSYFQFSPRTNHNIQNVTSWQSRFFLNDDQDPGLALLIHDTLDLARKKVDAVLRLDNAMTYSLKIKNEVNNYVVQLIREQIEINKHAILTHPMNLRSSSIFHSPLPQIHSQQPEAENLIYSSSTPLQVQHDQCASFEAPSKSHLEPIPFPVSSIEETPTANDIRHPSPLPRSCSNTVMKLPTPRRKLDSNGLFSDAYLNADIIPNPSIESTISIDRDNNTNSRGSSMKQYGIGEATDSRTSNSERPSSSSSRLGIRSRSITPRQKIEYSHVDNDDRTNEMLSRDKDSLQPQPSVDTTITSSTQATTTGTKTNSNNSTNSVLPKLMTSISLTPRRGSPSFGNLASHSMQQTNSFKLIHDKSPISSPFTFSKDFLTPEQHPSNIARTDSINNAMLTSPNMPLSPLLLATNQTVKSPTPSIKDYDILKPISKGAYGSVYLARKKLTGDYFAIKVLRKSDMIAKNQVTNVKSERAIMMVQSDKPYVARLFASFQNKDNLFLVMEYLPGGDLATLIKMMGYLPDQWAKQYLTEIVVGVNDMHQNGIIHHDLKPENLLIDNAGHVKLTDFGLSRAGLIRRHKFVPHKSSLSISSTLPIDNPANNFTMNNNNSNHSQLSTPDSFTSDHKQYNRSKKSSLGQQYEHSEYSSTSNSHSMTPTPSTNTVVYPSYYRGKDRSHGSSNIDLPASLRRSESQLSFSLLDISRSSTPPLANPTNSNANNIMRRKSLTENKSFSNDLLSSDAIAATNTNINSNNNISLSPAPSDLALFYPDDSKQNKKFFGTPDYLAPETIEGKGEDNKQCDWWSVGCIFFELLLGYPPFHAETPDAVFKKILSGVIQWPEFKNEEEEREFLTPEAKDLIEKLLVVDPAKRLGAKGIQEIKDHPYFKNVDWDHVYDEEASFVPTIDNPEDTDYFDLRGAELQDFGDDIENDNANILFGKHGINTDVSELSAANLSPPLNHKNILSRKLSMSNTTNRSSNNSNSSVHDFGAHTPVNKLSIASVLESVPQETGYITPNGTGTTTTSAKNSPNLKNLSLAIPPHMRDRRSSKLNDSQTEFGSFNFRNLSALDKANKDAINRLKSEHFSEQPGVHRRTSSASLMGSSSDGSVSTPGSNASNTTSGGKLKIHKPTISGSPSTFGTFPKTFLRSDSFSTRSYSPERSISIDSSTLSRKGSIIGDNQQTTANSSDSPTMTKFKSPLSPANTTTVSSYFSRQRVLSKSFSQRTNSSDLSAEESDRLQAISRVNSLRNRRRSGRKSSSTSEIGYHMDVLVCEPIPIHRYRVTKDLENLGCTVVSVGAGDELVSRATSGVSFDLIMTALKLPKLGAIDIVQLLKQTNGANSTTPIVAITNYFQEAATSRVFDDVLEKPVKLDELKKLVAKYALKKSQEDEEHTILSDSDETH
The following text describes a protein:
Function:
Acts as a co-chaperone for HSP90.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLAEEIAREEWKLHLYKMEERKLKGTEISLINHPQPLAFWQSTTSTDEQLQKVRTTLREYRTLIQESENRLAELRRRNIFGTNPIIKWAEQVNMVYLNIELPEMVWPDARNLQINLAEGLLNISATIGAGPQIYQMNVHLRDRATLYRQRLHPGGRGVECTLRKQEPNIWGKLIQGDGETPSYVKRDWIVRYVIESTIGENLKSYRKKLIVEGTLGDSLDALGKLTVEDPFDHHVLFLWFED
The following text describes a protein:
Function:
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MTLESSLHLLTPDQLSSLAHLQISVPELCKTAHYAEIYGHHLLPDQKCPGRYSEKARDVILLKVLESENYDATKAGDKLLTVLRWRKDYKPMDEDRDLPVLDGHVTTVAATNLPQTTLWHRSSATHIPNSIYIRWKVGLIEQAISTLDFSSPDNSSKLTCVEDFNHNMYDEVLWKQLSTLREFYPGIFDKTFFVNVPLSLRIGLRFFNKSNPVYNRRNSVILGKGKELKKHLGNWVPREYGGEGPGLEIQGRNVRGYSAYEHHALRHVLTTSPTQYSHAKGDAYRDSYGPPDDDDVPPYYH