lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAGADATFPLDLTKTRLQMQGEAALAKLGDGAMESAPYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRRLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAALVNMGDLTTYDTVKHYLVLNTALEDNIATHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCVIQAVQGEGFLSLYKGFLPSWLRMTPWSMVFWLTYEKIRQLSGVSPF
The following text describes a protein:
Function:
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MGAAAWAPPLRVPFLLLLLPLPGMPAGSWDPAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRVISLEDFMEKLAPTHWPPEKRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYREQWSQRFSPKEHPVLALPGAPAQFPVLEEHRPLQKYMVWSDEMVRTGEAQIHAHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTAAPLTMTMCLPDLKEIQRAVKLWVKSLDAQSVYVATDSESYVPELQQFFKGKVKVVSLKPEVAQVDLYILGQADHFIGNCVSSFTAFVKRERDLQGRPSSFFGMDRPPQLRDEF
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MNVDYPMNNIPQASSLLRKNNGKRLSMASAARTSLLGNLNLNGTSGGASGRNSNIIDSSSLSMGNTGKRRSLLSTPASINRRRQSSLLQAPMSSSQMSSQSQQASQQTQAPFNQDQRPLRDKNYQTLIQQEIYDFLLANKFELEMNHPLTFKTLKQPTQKDFVVIFQFLYNKIDPYYRFTKSIETEVFLLLKILNYPYLDGINRSQISAVGGQNWPNFLGMLYWLVKLNLSVLNLNSKVDLISPDDEFDKIFINYITQSYRAFIDERDDYSEYYDEMKSRFDELNNNIIQDIENISNENNELLNQYNELNGQLDILENSEKKSKALENDLIKFKAYIETMESRKSKWSEILNKITQEIGNCEVELNNIESVKRDYEAQIGQQGLTPNDIDNLNTERDKLSKSIDLISNSLEDLKDVYHNKQINLQKNYQSLENFLKQYNNLIYKIQLKNHNYDYNFEINFRNNTIINETPDLLKPNEIINKNLKDEKIQLLNYKSIINTNVHMHQDEQIKLQEQIDLISELIMERREEIETLEAKLTANKSTYDEIYETMINDTTTYSMQIEKLERELRSIKINTNQGFIEVENKFQNIQIEYDELLYEIHSNRSILHDKIQKIIESTIGFKINIQSNLEDLENLAFDEFEKEDKKLNKN
The following text describes a protein:
Function:
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
Subcellular Localization:
Nucleus.
Sequence:
MEHQIGAFPSGLMIGKHIESSENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEVQAAAPSHSSSLPLTYGVSSSVGTIQGAGPISGPSSGAEEPFGKKSKKEKKEKGKENNKLEVLKKTSKKKKMEGGARKLVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQIKDGGLQPQFEIVPEDDPQNAIISSSADACHAELLKTISATMGKLRPNLLPSGADFFGFSHPTIHNLIQSCPGARKCINYQWVKFDVCKPGDGQLPQGLPENDATISFEAFQRQTFDEDHNDPILQGSLDLPELQPTVFVSSYQPMFLTHEPLVDTHLQHLKSPSPCSPTQSSD
The following text describes a protein:
Function:
Acts as a chaperone for the L4 ribosomal subunit, required for hierarchical ribosome assembly. Shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Distributed throughout the cell but is enriched in the nucleus.
Sequence:
MGKPRPHKKKASKTREKSVLSAGGSISKRKMNEDPRKLLEQATILLQTGQADAALSIAQQALEIATSNSPAQLSSLNTIAEIYVELGEIDLARKHFLQAVELDPTGSIPESEGGGAEKFLWLAQLSELGGKDSVQWFEKGVGALRGIFRRSPLFFIAFSRASYQADIFRWEEDAESRCENLITEALLVQPSSPEVLQTLASIRISQLREDDARAALSRSLELWKDLPPEDPHVPDFPTRISLSRLLMEVSMLLEALEVLERLILEDDQSVEAWYLGGWCLQLLAEIGEAPRDPEAESNETPESKRHASLVASREWLKQSLMLYDLVQYEDERLKEHALELVEAMNKELGEEMEDDSNVEDGEGEGEEEWEGIESDSDHEMADS
The following text describes a protein:
Function:
Component of the cytosolic Fe/S protein assembly machinery. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
Sequence:
MSFFADLPKDNKKCIKIGSPLALSLSDCLACSGCVSADEAGALSEDLSFVLDLSPQTSFVLSPQSKINIFNLYREDGMEYREFEAVLSSFLRSKFNIHRIVDTSYLRSKIYEETYREYMATNHLIVSACPGVVTYIERTAPYLIGYLSRVKSPQQMAFSLVKGSRTVSVMPCQDKKLENGRDGVKFDFILTTRGFCKALDSLGFRRPARASGKSLCSMEEAETTQWNIGTSSGGYAEFILGKHCVVETREIRNGIKEHLLDDGRTISQITGLENSINYFKSSKTKGPRHKMTEIFLCKNGCIGGPGQERVNDVEMDIREYDRNGREQPRIFYSSPGLEEKRVFREVKAKRVDLRVDW
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRILRSRPLTNSFSFYGRPFSSNISANPPKEAIISSSSSSSSSSSESLINDQAPSAPPSEPVAKKSSSAFLKFAIFGTLAGATAAAGYASYAYTLDEVDEKTKAFRTSAKYTVGDNASSLDKFQALLYSAAMTVPAKAIELYLDLRRPIEEQIRGFAEPSSEKLLPDLHPLEQHIFTLVLDLNETLLYSDWKRERGWRTFKRPGVDAFLEHLAQFYEIVVYSDQQSMYVDPVLERLDQKGCIRYRLSRTATRYQDGKHYRDLSKLNRDPSKILYVSGHAIESCLQPENCVPIKPWKVEADDTVLLDLIPFLEYVARHRPADIRPVLASYQGRDIATEFIARSKDHQRRMLEQRQHGRFWQR
The following text describes a protein:
Function:
Chaperone necessary for the assembly of mitochondrial respiratory chain complex III.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNTITGGGAGVNGAQPVRGLPKSILQYIPEPIQPLFENPLFSAGFGLLGVGSLVAIGRKGFQSVLIQGRRYFFVSVEVPSKDKSYHWLMDWLATKKDKTTRHVSVETTFHQHESGEIVSKINFIPSVGTHYVFYRGRVIKVERSREKNVIDMNSGNLWESITLTTLGTKRNIFQKLIEEAKIMALDKEEGKTIIYTSMGTEWRRFGHPRRKRPIGSVILDKGISETIITDVRKFLGNADWYNERGIPYRRGYLLYGPPGTGKSSFITALAGELQLSICILNLAGKGVSDVTLNQLLSTAPQRSIILLEDIDSAIQTNETNQPSSSSSNQSSNAISSGGMQYQGYSGPSSTMQYQGYGSSLTFSGLLNALDGVAASEGRILFMTTNHLEKLNKVLIRPGRVDLQIEIANSSPYQLEKMFLKFYPDHQELATQFVDKVKHLSLSPAQLQAYFMNFSTDPVEALENVNQLNLNK
The following text describes a protein:
Function:
May play a role in cellular stress response.
Subcellular Localization:
Cytoplasm.
Sequence:
MELSSKLRDLILNTHVPLVLEQFPLKWECFEGSLHDWCKRFDKEATCLPAFELMALADSSTPQWERKRTKSSQLLNMQQFLRKYGVLDGDSTHWAAYQYKKADEVPLSCRSGIGFSSFGFPDIGNDYRFWLGSEQANTPCHYDTFGVNIVVQVHGCKSWLLFPPETPLQSTRIPYEETSVYCLENFYAPDPAKISSYEHLGRQAYHCNLQPGNVLIVPRHWWHYVEAKSTSLSVNYWVPLKVDMDLILDEFLVMHIVESFVRGESNQVKQYLLNPNQLDNVSTKPSDLFAQFEQAVQNLESGKSTRQLYDTDYISQADWKTLLNSINLSVRPLEVMPHEEYKLLLNANSKRFRVAANPPETTPISSNCELLVSSMCAPRVIAEMKREFFRRLGKSNSL
The following text describes a protein:
Function:
Can activate transcription (By similarity). Essential for light-regulated PHYA nuclear accumulation and subsequent PHYA phototropic signaling processes. PHYA-specific signal transducer in response to continuous FR lights. Mediates the association of PHYA with HFR1 and LAF1 in the nucleus in response to FR conditions. Contributes to inhibition of hypocotyl elongation in continuous blue light (B).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles from cytoplasm to nuclear bodies in FR but stay in the cytoplasm in other light conditions.
Sequence:
MDDADKSCSPSLDHSDINDPMIVAVESLDTSKKRKLHAEESDLLPLPKHFCSEHQASLVNSSCPSSVIDYAECSYAMENTKTSDEASSSASFTGPSLYMFKDSIYSTGSSSSGYAATSSIEQCFSKVDHKTQEDTQDFTHMEFIYHDSEFAVEDLQEVLNPVESYILSSARWSVSNQDSKEATTKPTIDQEFEQYFSTLMM
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Subcellular Localization:
Secreted.
Sequence:
YLYQWLGAPAPYPDPLEPKREVCELNPDCDELADHIGFQEAYRRFYGPV
The following text describes a protein:
Function:
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subcellular Localization:
Secreted. Membrane.
Sequence:
MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTAHQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
The following text describes a protein:
Function:
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing an essential role during phospholipase C-mediated transduction. This function is essential in photoreceptors for light-activated recycling of PtdInsP2 during phototransduction. As a key enzyme of the phosphoinositide pathway, indirectly involved in the polarized secretion of basal membrane (BM) proteins in follicle epithelial (FE) cells through promoting PtdInsP2 synthesis in the apical and lateral plasma membranes of FE cells. PtdInsP2 controls the localization of Crag and perhaps the localization and expression of strat, both of which are essential for restricting the secretion of BM proteins to the basal surface.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Lateral cell membrane; Multi-pass membrane protein. Note=In follicle cells, detected at the apical and lateral regions of the plasma membrane.
Sequence:
MTIAEHDNVFIFVPNLIGYARIVLALIAFWFMSTNYVISGWCYVTSALLDAVDGQAARAFNQSTRFGAMLDQLTDRCGTTGLLVTLAYFYPRYMFWFQLSIAIDVACHWLFMQTSVVVGRSSHKVNDNFIMRLYYQKDILTFMCCVNELFYVCLYLLHFTYGPLIFGASLFKILAFLTGPFAVLKALISVMHAYVAGIDLAAVDVRERQERRQKSEPVSGKKVE
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Domain:
TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus.
Sequence:
MNLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDILDMEEPINRRLFEKYLKDDNGSRDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLDSLPLNKLCAEEQELLRFVFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFRDFEVEKQNTEEAGLAPLQNSTKAPESRPNLEETFEIEMNESDMMLETSMSDHST
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MLGVPFLERAISSWIRPHSLDDPVDRLNYFVTTMILLFFGIMVSAKQYVGSPIQCWAPMEFRGGWEQYAEDYCFIQNTFYIPFEQEIPTDVQDRQDAEIGYYQWVPIVLALQAIMFYVPNWLWKTLNKLNGVDVENAVVEASKMRGLAGESRRIEAEKLAEYLADAIDMKGGVGRSKDYRILCFRFGNSLGSYVSVLYLFTKMLGDLFNGREWHESGMFPRVTLCDFAVRKLANMHRYTVQCVLMINMFNEKIYLFLWFWFLLVLSVTFINFFYCFSQMIFTRSRINSCKYWLATLFPDGVMPRDEMMLSRFAISGLQPDGILVLRFIEGHAGSLPAKELAIALFKRFVTMQNKQHLPISTQSTSPGFEAPHEFNEKESFLEAGSPHDLYNPDKAAIMQPDYKH
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MPAATIGQCISAGERGRGAPRKPPASGDLQPTLEKDNSAREASVLPVGRGDDIGVQAPGREVEKQENVLNGKNEEGARGWACVGRNGTGKVLDGHAKEAKAGRGEALRAGDPSSKSIGQDRVDADRPLQLENEAFSRAAEASAGASNVTSGILGIIESAPQNVTGDPVTAGISSPPRLTIPNTSPGHGTQTQTNTPEFRSPPRALIIPHRFSFDSPHRPTLIPESPEIRQLKKRLSTSKIEADPVLASYFREVDTSTREHLVEEALGFPHVSAEDLANRPFNLPANHPANRRSFKTVKRLITLQDKEGNKYVNQYLILKPLGQGSHGKVKLSLNAADGCLYAMKIIDKALLRKKRLGSRAAENDAMREIAIMKRLAHPNIVELHEVIDDPLDDKLYMIIEYVEGGPVWGRTHQDPLPEHLARKYFQDVVRGLDYLHRHKIVHRDIKPENLLLAPDGTVKISDFGVSNVFEESDAMHRPVGTPAFLAPEACSSDTFRGRDLDIWALGVCLYLMVVGRLPFEAESVAGMYHRIVHEPLAFPAGTQLSPELVDLLTGILEKDPLRRLQLAQIMAHPWVNKQGEASSLPLQTAVGPVESLTLTIE
The following text describes a protein:
Function:
Specifically methylates the adenine in position 2030 of 23S rRNA.
Sequence:
MNYRHAFHAGNFADVIKHIVLARILTYLQDKPGAFRVIDTHAGAGLYDLESDEARRGGEWLTGIARLMQARLSNETAALTKPYLDIVRAFNPKGELKAYPGSPLIARGLLRPQDRLVACELEPKARKALIDVLRRDEQARVVDLDGWVALPAFVPPKERRGLVLIDPPFEAKNEFERLGEAFSEAFAKWPTGIYVIWYPAKSRRATDALAQLVARLAAAAKPPGKCLRLEFSAAPQLDGAALTSTGLLIVNPPYTLHGELKTILPELEMPLGQGGAARFRLEVPRP
The following text describes a protein:
Function:
Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity).
Sequence:
MSDQITVDELWAECEQTFEDLFLNLKKGLSRKRYMEIYTKIYNYCSSANEKALIDFYIPKVKVLVAQKAVEIMSRSESYPNDALLLFFRNQWNEWKMSSNVLKNLLSPVNKIHSSDKKTTSSSANQNESVVYSDTLNSWRETAFNPLKNKLSVSLLQIIKNDRTGFSTNLQVLSDSLECYVQLGPEKNKLEIYQSCFEQQFLQETETFYKAESADFIEKNGVCEYMRHVYNRIEQETNRVNQYMPISTLEKLTKILNNVLISNYKEQFASKFLDILIEDKSSDLVMMYSLLSRVNHLTPLKNIFSDFIKSEGLKEIESNLKEAQEKPQVLISILLKIYSRFNIMIKECYGNDTDFTTAMDKSFSILVNENPASYDPKKKESNIPVVLSKFCDQILRKGPHHISDEAELEKKLTEAVCLFKYLPDKDIFMLNYQKMLSKRLVEDLSASEDAETLMINKLKNYQGFDYCTKLTRMITDMRLCKDININFQNHLNEKSLTLPYQFNFYVLTNGSWTLTNKQTATPFKPPSEMLSSITYFESFYKKSYQGRVLTFLYDFSRADVDSRQAKGKIYKLTTTAYQMAILLMFNGADKITRFLINDTIGLDETSIRLPLLALIKTGIIECSEPSFKNWNNDTEFTVNSKFSSKKMKVSCNIAVQIGETKQSEGQQTVSEQEIEKERFFKLQAAIVRIMKSKKTMTHNDLTVETTTQVSKWFTPKITAIKKAIEYLIDQEYIRRTTDDNPSARKYEYMA
The following text describes a protein:
Function:
Component of the HIR complex, which functions as a histone chaperone that cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to the promoter region of histones HTA1-HTB1.
Sequence:
MDQKAIVLDNSKSGSKQTKSSGKMQTQTDTNAEVLNTDNSIKKETGSDSEDLFNKFSNKKTNRKIPNIAEELAKNRNYVKGASPSPIIISGSSSTSPSGPSSSSTNPMGIPTNRFNKNTVELYQHSPSPVMTTNKTDTEEKRQNNRNMDNKNTPERGSSSFAAKQLKISSLLTISSNEDSKTLHINDTNGNKNSNAASNNIPSAYAELHTEGNSIESLIKPPSSPRNKSLTPKVILPTQNMDGTIAKDPHLGDNTPGILIAKTSSPVNLDVESTAQSLGKFNKSTNSLKAALTKAPAEKVSLKRSISSVTNSDSNISSSKKPTSEKAKKSSSASAILPKPTTTKTSKKAASNSSDSTRKKNASNKTTSAIKKESNAGSKLNTVKKENSSLSSIKATEKEKDKGGNSTEAKNSTSNVRKEPTAKSPKRLVAAPTVSPPKILQTAETKAKEPSILIDVPLYQADTNDYLDENGQVIFNLSTLIKEKYHPKSKELAQLKDSKRNLLMQLSDHSNGSLEKEKDEEGDVIELDDDEDMEEDEGEIDTETNTVTTTISPKKKSHPMKGKNLIGKYDVEDPFIDDSELLWEEQRAATKDGFFVYFGPLIEKGHYASLERANGTMKRGGVKNK
The following text describes a protein:
Function:
Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent 3'-5' DNA-helicase activity. May be involved in the control of genomic stability (By similarity).
Miscellaneous:
MISCELLANEOUS: Unlike orthologs in vertebrates, this protein does not have an exonuclease domain.
Subcellular Localization:
Nucleus.
Sequence:
MISDDDDLPSTRPGSVNEELPETEPEDNDELPETEPESDSDKPTVTSNKTENQVADEDYDSFDDFVPSQTHTASKIPVKNKRAKKCTVESDSSSSDDSDQGDDCEFIPACDETQEVPKIKRGYTLRTRASVKNKCDDSWDDGIDEEDVSKRSEDTLNDSFVDPEFMDSVLDNQLTIKGKKQFLDDGEFFTDRNVPQIDEATKMKWASMTSPPQEALNALNEFFGHKGFREKQWDVVRNVLGGKDQFVLMSTGYGKSVCYQLPSLLLNSMTVVVSPLISLMNDQVTTLVSKGIDAVKLDGHSTQIEWDQVANNMHRIRFIYMSPEMVTSQKGLELLTSCRKHISLLAIDEAHCVSQWGHDFRNSYRHLAEIRNRSDLCNIPMIALTATATVRVRDDVIANLRLRKPLITTTSFDRKNLYISVHSSKDMAEDLGLFMKTDEVKGRHFGGPTIIYCQTKQMVDDVNCVLRRIGVRSAHYHAGLTKNQREKAHTDFMRDKITTIVATVAFGMGIDKPDVRNVIHYGCPNNIESYYQEIGRAGRDGSPSICRVFWAPKDLNTIKFKLRNSQQKEEVVENLTMMLRQLELVLTTVGCRRYQLLKHFDPSYAKPPTMQADCCDRCTEMLNGNQDSSSSIVDVTTESKWLFQVINEMYNGKTGIGKPIEFLRGSSKEDWRIKTTSQQKLFGIGKHIPDKWWKALAASLRIAGYLGEVRLMQMKFGSCITLSELGERWLLTGKEMKIDATPILLQGKKEKAAPSTVPGASRSQSTKSSTEIPTKILGANKIREYEPANENEQLMNLKKQEVTGLPEKIDQLRSRLDDIRVGIANMHEVAPFQIVSNTVLDCFANLRPTSASNLEMIDGMSAQQKSRYGKRFVDCVVQFSKETGIATNVNANDMIPPELISKMQKVLSDAVRRVYTEHLISRSTAKEVATARGISEGTVYSYLAMAVEKGLPLHLDKLNVSRKNIAMALNAVRVHLGSNVAVLTPWVEAMGVVPDFNQLKLIRAILIYEYGLDTSENQEKPDIQSMPSTSNPSTIKTVPSTPSSSLRAPPLKKFKL
The following text describes a protein:
Function:
Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus, associated with the U5 snRNP.
Sequence:
MAETEAGLEVEEPTEDDTLPSDTVSLSDSDSDLSLPSGVEVQALSPERLSGESQEDSGPDDPPSHPTGIPTTAVQPFHLRGMSSTFSQRSHSIFDCLESAARQEPCSAPQTSVVDNCSFKRPVAPPSQTPARSLSRVHGNTDPTRVHPVPDYVSHPERWTKYSLEDVSETSEQSNRDAALAFLSSRSQASPTDYVPFFNQDPSSCGEGRVVFTKPVRGSEARAERKRVLKKGVVSGAGGEASVELAHLAGPEAEEWSGHQGQPEVVVPSEAARPESSSGPIGMKTVGFHGSKKRSRDHFRNRDSNPEGPGSERGPSV
The following text describes a protein:
Function:
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.
Subcellular Localization:
Lysosome.
Sequence:
MAHSLTFIVLIIYQELLTGIISVEVIRKSLTEGERLQHSDTFQQDVNNELYQRWINYQSSLQRQAFLNSALGKSNQSAQYGVNQFSYLSQKQFKEQYLTARAEAAPKFDQSKSEIKVKANNPPRFDWRDHGVVGPVHNQGSCGGCWAFSIVEAIESVSAKGGEKLQQLSVQQVIDCSYQNQGCNGGSPVEALYWLTQSKLKLVSEAEYPFKGADGVCQFFPQAHAGVAVRNYSAYDFSGQEEVMMSALVDFGPLVVIVDAISWQDYLGGIIQHHCSSHKANHAVLITGYDTTGEVPYWIVRNSWGTSWGDDGYAYIKIGNDVCGVADSVAAVSV
The following text describes a protein:
Function:
[Isoform Peroxisomal]: Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification; [Isoform Mitochondrial]: Catalyzes the transamination between L-serine and pyruvate and weakly contributes to gluconeogenesis from the L-serine metabolism.
Subcellular Localization:
[Isoform Peroxisomal]: Peroxisome; [Isoform Mitochondrial]: Mitochondrion matrix.
Sequence:
MFQALAKASAALGPRAAGWVRTMASHQLLVAPPKALLKPLSIPTRLLLGPGPSNLPPRTMAAGGLQMLGHMHKETYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALINVLEPGDSFLVGVNGIWGQRAADIGERLGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSSGVLQPLDGFGELCHRYKCLLLVDSVASLGGAPLYMDQQGIDILYSGSQKVLNAPPGTSLLSFSDTAKNKIYSRKTKPSSFYLDVKYLANLWGCDGQPRMYHHTTPVVSLYSLREGLALLSEQGLENSWRKHREAAAYLHGRLQALGLRLFVKDPALRLPTVTTVAVPTGYDWRDIVSYLIERFGIEITGGLGPSTGKVLRIGLMGCNATRENVDLVTEALREALQHCPKKKL
The following text describes a protein:
Function:
May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.
Miscellaneous:
MISCELLANEOUS: [Isoform 4]: Splice site between exons 6 and 7 is non-canonical.
Subcellular Localization:
[Isoform 4]: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.
Domain:
Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven.
Sequence:
MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGVCPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPGVLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGCQYCHSRTEQQFHPESTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDSKQNHLAVFAAVHPPAPSVSSSVASSLASSAGSGSSSPTALPAPPARALPLGPASSTVEAVLGSALDLHLSNVNIASLEKDLEEQDGHDLGAAGPRSLAGSAPVAIPGSLPRAPSLHSPSSASTSPLGSLSQPLPGPVGSSAMTPPQQPPPLRSEPGTLGSAASSYSPLGLNGVPGSIWDFVSGSFSPSPSPILSAGPPSSSSASPNGAELARVRRQLDEAKRKIRQWEESWQQVKQVCDAWQREAQEAKERARVADSDRQLALQKKEEVEAQVIFQLRAKQCVACRERAHGAVLRPCQHHILCEPCAATAPECPYCKGQPLQW