lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a significant role in p53/TP53-mediating signaling pathway.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRASPCISQPAASWHPRPSALRPTAGSGPDTRTPGTVEDGSAPCPAFRSPAVSPCGEEPCCFQISPAEETLELGRLVSPGNCDTLSPRAAGFYACHVRSLIPCRSTKGRWPLTASAAGLSSFSG
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity). Probably involved in early processes for vascular development. The PEAR proteins (e.g. DOF2.4, DOF5.1, DOF3.2, DOF1.1, DOF5.6 and DOF5.3) activate gene expression that promotes radial growth of protophloem sieve elements. Triggers the transcription of HD-ZIP III genes, especially in the central domain of vascular tissue.
Subcellular Localization:
Nucleus. Symplast. Note=Mobile protein observed in symplastic trafficking; movements are repressed by HD-ZIP III proteins.
Sequence:
MVFSSIQAYLDSSNWQQAPPSNYNHDGTGASANGGHVLRPQLQPQQQPQQQPHPNGSGGGGGGGGGSIRAGSMVDRARQANVALPEAALKCPRCESTNTKFCYFNNYSLTQPRHFCKTCRRYWTRGGALRNVPVGGGCRRNRRTKSNSNNNNNSTATSNNTSFSSGNASTISTILSSHYGGNQESILSQILSPARLMNPTYNHLGDLTSNTKTDNNMSLLNYGGLSQDLRSIHMGASGGSLMSCVDEWRSASYHQQSSMGGGNLEDSSNPNPSANGFYSFESPRITSASISSALASQFSSVKVEDNPYKWVNVNGNCSSWNDLSAFGSSR
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MPKPDPIPGVSSGMEYLVDLNKILVHQQVEVAELLSGQESCNKYVILNTLGQQIYFAHEESSPCCRMCCGNERSFVMHLFENSGIEAIRLRRNYKCCAKCAWCTCMPCCVEEISVEAPVGEIIGYCRQGCSFISPKLEVQNKNNELMYSMRGPMCFCQNNCCRKDVNFSIKDTNRNIIGKISNEWSATNRERHSDADNYSVTFPYDCEAEMKAVLLAIMFLIVSSSNKLIYSFIYYSN
The following text describes a protein:
Function:
Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (By similarity). Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).
Subcellular Localization:
Membrane.
Sequence:
MSTENTSLVVELLEYVKLGLSYFQALPLAQRVSIMVALPFVYTITWQLLYSLRKDRPPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTSMVTLPTAPAKIYWEKRHPEQKY
The following text describes a protein:
Function:
Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress. Wnk-1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation. The membraneless compartment concentrates wnk-1 with its substrates (By similarity). Phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals.
Subcellular Localization:
Cytoplasm. Note=Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress.
Domain:
Disordered regions undergo liquid-liquid phase separation (LLPS) for the formation of a cytoplasmic membraneless compartment that concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK.
Sequence:
MPDSITNGGRPPAPPSSVSSTTASTTGNFGTRRRLVNRIKKVDELHPAQENPTMGSHWLSEQERSRLEAVQQDWRRTRPMKFQWTSKKRPDDPTTSSPSTVSISNALENSTPSLNNVSSITNSSSPFSLSSAATSTASAIIPFTSNVATNHPHLNHHVSRIPQAIVTGGTNGSLPPLLISPTSAAAATPLISGKAGPMSPSTGSPINVAATVLQNAVSSPQHSIFDRSRLNKIPPNTSLASSSSPSDAANNDKPIQQRHSILSNVRTLTQAMVNDGPRTLTGDDMDKMVSEEERARKEQEKREEEEKAARRIDVEDDFDAQEKPIDKSKNGRFLKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKMYLKRFKRINIKVLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLNDLNVEIQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVVQQMIEQQHIPDEDTRMITKLIKDKVDAFRRDRDHRLLEIKRAKEEEERIREEAEIKEELRLRAEAKEKEKERLEKERLEKKAAAAAAANPNPTPIPPTPATPHSSAQQQPIPPPLSTQTSAEIQQSAQQPSVPVTMIANIPAMSPTSAQPQPVLSPTSAAVPVPTTMIHVPKPSEIPVQNVATTAAPVAANNVPPSPAPFKTEDIQTPTLAQNTVPRTISTDASGLVINTPASIASPSPAPSATDVASTTAPVTPAPTPTTTTDGGAAAASTTTENKEEKRKSNKRKVVMEILGCDESRNFALVSCRLDTSHKSVTFQFAPGTDKPCTIATKLLAEDCLLKVHVHIVEAQLGEVIQLINSDGKKGVGTKLATVLDPNSTEPPTITAVMPKDSSAATASNTKPKIEIEKTPPTRDASQEPNNVQVTNVRKVSQESNAESVQSIPRPGGIIVMSPTNQTDSAPPPTGAAAKPSRFQVTKSADPIATPISSSISTATVIPIVAATPTNITSEPVIVQPITAQVITHLATPSPVSHSLSSNSSPSATTHSNMSSIQSTTSVPGRRFTVQPVSQAESGISSSISTPHPEPTPAITSCPPPVPSVPPVVSNGTLNLEVAPKQTPSATNQNVDTQHSSSTASTATLVSETPATVHVTPISVPAPVQEPLVIDHHSDVLTQLDSELRKCFQVSGVSHSASPSTVVESLTSMTPQTIPLACQTVPASIGQAPAVIAAAHAASLIPNASVPQSPSRLDAETGLAGLHEKLEALKMEQDRREDMGDDAIGTTTTDGKDEIPIDTLKGLAEALGKVIHADGRETTPMPPDHPDLTDASTQQLISPSNPDVLTTMSSAVEGSASSTMIEDIDASTSAVDASMMNSMPPGAQNSTDQIPAAMTLSMDQECAQSMTSSITRNTTGTKLATFENLETALSSTLGTHIRQPNAPSSRDETTAPMTPSFTNERIGGGGGGGATSFSIGTPPSHSPFPVSECDYDLKGQMDLESEDPEVIQMIVRHRMEQHKLLEKQRVEIERLRSKIRVPRATSVNPEMIGDDEADTTLTALQSALGNASLSLPASPPPNTEIPDNEGQHHCNSFRCIGDPNDNVSIVNQIKQRLGIIPSSRQSVRSATSSSPSTPPSSSSAPPKSLSSPTKSYVSHCSLSIGYGSTASSEQQQREPSPSATTSSFLSDPATGVIENV
The following text describes a protein:
Function:
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL
The following text describes a protein:
Function:
Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MATRALLLLLLLPPLLLLAGCAARPAPPRAPRHSDGTFTSELSRLRDSARLQRLLQGLVGKRSQQDPENNTAWTKSGEDRLCQLWSHMPALQAWMPMKPPVDQAWSPWLPPGLRAGALVSEPAIPAAEGSPMPP
The following text describes a protein:
Function:
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MSVDLSGPHSLPSCEEASNSGDSSPMPAVHLPEENYSCLQVSATEMLCTETASPPPSSGDLPLQDSPDSSSNPKLKLSGPRLTRALRRKKRTRSSPRKQKMRTVFSQAQLCALKDRFQRQRYLSLQQMQDLSTILSLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLTQGSAPVEYPSIHCSYSQGYLMNASGNLPVWGSQTWTNPTWNNQTWTNPTWSNQTWTNPTWSNQAWSTQSWCTQACNSQTWNAAPLHNFGEDSLQPYVPLQQNFSASDLEANLEATRESQAHFSTPQALELFLNYSVNSPGEI
The following text describes a protein:
Function:
Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MGRKEYNRQAPKRDRNDDDQASKRRKTMHNGESEPTAFSTEFSKEEIESEVRKPKHKVAVMIGYAGTGYKGLQINTKEKTIEGDMFKAFVAAGAISKANANDPKKSALVRCARTDKGVHAAGNVLSLKLITEDPNVVENINSHLPDQIRVWGIERTTGSFNCYQMCDSRWYEYLIPTYSFIPPHPKSFLGKELLQAAEKEGVLEKFNQLQEDAASFWTDAEKEFVQPILDNLDPQLAADVMEAIHAAEESNEPIGKNIKKNKAEGKDGAEIKEETKEEPITNNEAETEGELAPKEEPVAVEVNEDGDVKQSPKPAAEVEKEEPEAMQGIETTGEPVVKDETNQDGEAKPEADGVQEISKSILTPLEKAVKEVKAAYIKAKKAYRIHESRRQRVQEALNQYVGTYNYHNYTILKNYSDPSSRRHIKSFKIGPKPIIIHDTEWLSLKVHGQSFMMHQIRKMVAMAALVVRCASPMELIKETYTAAKISIPKAPSLGLLLEAPVFHNYNEKVAKDFDREKLDFEKYREKMDEFKQREIYDRIFRVENTENQFHTFFHHLDHHRSDYFLWLTASGISAGRQRGAGKDALDASDDEADVNGEEG
The following text describes a protein:
Function:
Terminal uridylyltransferase which is involved in the post-transcriptional editing of mitochondrial RNA, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA. Specifically, catalyzes the addition of Us to the 3'-hydroxyl group of guided RNA (gRNA), with a preference for RNAs terminating in 6 Us, but also can add Us to RNAs terminating in 6 adenines (A), 6 cytosines (C), or 6 guanines (G). Can mediate RNA-independent UTP polymerization in vitro. Can mediate pyrophosphate-dependent degradation of synthetic RNA ending with U residues in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MSKYSLLFNQGTKDGTNASSGSEANSANITSSSAPASSTNTSSPTSSESAVVSPPASTSPRRRLIHRRHGSAGAAEVAPLSLPKRPQQPNEEKHENFISDSVHHCSNRGASGSELKALTTSGSETVMSASPDIAFEAPSPPTASASPPLESTSAVESDGDVVIDDMMRYQEGDSGGSRSATSAAAAGRAVSTNDAAALINGDPGPLSSAVSSSSSGSPHTPPRLFTCDMCLQYVSTSYEALEQHALDQHGDALADYTRLRSVAEKLVPVWDEVLKRKASVVQQWGKRIFAVAVQRDAGAEKMAEAHRARAQLELVVQRWHPRAKVFIFGSSVAFGVWDGISDIDFTVVDVDELEAGTWPPSEKNAVRSITELLRRAGFSFINLEPISHARVPIIKHHASLPIRLTDEQRHRLYEEARQSAAAVDLVAAESLASSSPSSAQETTDEKGLTQLEAELIIARSVRYSLNLPAGPPDSAILEASIRLAVGSAAVQQVWWNRTRDMCCMTFDTTTNAVKASTCPLHFMSAGMRARVQPLHEECRPELYGMDFDLSFRAFGIRNSHLLRRYLLSHPCARPGALVLKDWSKTSGVNNSVNGYLTSYAINIMWIYYLVHRGVIRYVCPARDIPASLRCNVDADPQYAAMVDPTWTPEERAAMEAQAGELLLGFFYYYAFEFDWVNHVVSLNRPGITTKASLGWDVEDVAQTGSPAPHFGVAGSQHQYNLAGAEGQQGDLHSGTSLSAPQTRPLTGYDGMMASSASAAARRSRATTRYSFCIEDPYEENLNLGRHMGVTKTLRVQTELYRGLLSLLKDDPQHCCVFAGSTNSSGSTDSNGAMASGAAEPAMVAARTPSEPTELPVRVLYKLMAISTRELAIARRRYSATVTAGTEFPGALLSDLEAAFLAQAPTEWKLARQVWNKHQLLHRLGLKLHAREYVLPRREVGVRRLAAKAPPGVVPASAPEPTFTAEEVAAAAAESGQAPFSAEHAPTSSEEVTQMNRAFLGAFPARRLPEDLMLAMTKGYSCLTPSWVAWSKPWAALSAWWTDRLHSPSTTTQGEDPLASGTCEQGGVSPSLPTGAPHHISAVPEKSAGAMHQTRTQLRRHVVAEIASTPAARRVLRLLFR
The following text describes a protein:
Function:
G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFSCFIWLSLPCFVNTFPTSGKLPLNRSLEEVLEIPTISGFFPWDNDTLADWQSFVGRSRHGADSQHVAAKALLIAAYSIIIVFSLFGNVLVCHVIIKSKRLRSATSLFIVNLAVADIMITLLNTPFTLARFVNSTWIFGKGMCHVSRFVQYCSLHVSALTLTAIAVDRHQVIMHPLKPRLPMAKGVIYISVIWVMAACFSLPHAIYQKLFTFEYSEEVTRCLCIPDFPEPADLFWKYLDLTTFVLLYVLPLLIISAAYMTVAKKLWLRNVIGDVTTEQYFALRKKNKKTIKMLMLVVILFAICWFPLNCYVVLLSSQTIRSNNALYFAFHWLAMSSTCYNPFIYCWLNDSFRAELKALLNICRKPPGPVEQRLPSTVPSYRLAWPENSHFKRLQVSHVPAAASNSHLGKTDISAVEPIVAVS
The following text describes a protein:
Function:
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Subcellular Localization:
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Sequence:
METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
The following text describes a protein:
Function:
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function.
Subcellular Localization:
Cytoplasm. Note=Located at podocyte foot processes.
Sequence:
MLRQILSDMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGKSVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAEREHLRAAKDSELRKTQSLELANSLKIKSQNCDLQAMKKTEPQNVTRKAASEEASGQGPRAIPTRKDDKAQTKPVKEKDHEEMKQTEDEKTKQIYKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPRRPPLPPKPQFLQPLGIPPKSLGNQGVIRTEISSAQMDTIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKANELLSTGVPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDKLPDYLELFQ
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPRQRRRGASFRGVYCPDAFPLSLEESVTEAAEVFRRSPSITVSGEYLVPPKPTEIKNRLTVVLDLDETLIYARQGPLYVRPGIETLMRFLADHCETIVWTSSKHRYADAVVAQIDTCGAVCHTVYRHRRWFNGTSATKELRLLGRDLETTIIVENTPDCCRGYERNAVLVEDYEGGELADHTLHTLLALLRDLVERHEKEGITVPEYIATTPRLAQQNVLTDKGTAMQAYCLLGAEDECAAPYSTVSKYPRINRDHLASAFPRPAQQPSRIRPAGSLGIRRKHACQQRVVY
The following text describes a protein:
Function:
In the 1-cell embryo, probably together with gpr-1, controls nuclear rotation and spindle elongation during mitosis. Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, spindle. Note=Located to the spindle and cell cortex when in complex with lin-5 and gpr-1. During early embryogenesis, cortical localization changes with the cell cycle. In one-cell embryo, uniform cortical localization from prophase to metaphase and posterior enrichment during anaphase. In the 2-cell embryo, uniform cortical localization in AB blastomere and posterior cortical enrichment in P1 blastomere during interphase. In P1, uniform cortical localization from prophase to early anaphase and then posterior cortical enrichment during late anaphase and telophase. Cortical localization and asymmetrical distribution is regulated by the csnk-1-mediated regulation of pkk-1. Enriched at the contact site between EMS and P2 from prophase to prometaphase.
Sequence:
MDVSYYDGPKDEVIEAMLKSAVTAMKLGQYEDGKGRLEDTMEFGTSNFQLLGTIYMYYGRVCRHLNHDAKALEFFEHELNMFKLIFNYPEACDSTRRIVQQALKMEKFSKARRFAEDLIDYTSNKKNGEKYIGQARILFASVCLEGCERDVESNQDEKKKLLSICAEQIAAVKLFNENNTEGAVSETKIMLIEAKCLSLDEKYEESRRKYQECIDFAIKTDQFEAVHIAYYDKALYAETYLLFFIIRDLRSALFYATKFGKERDVVKYKSKLSEEMLRNGEFHEAYLYGLEALVSIRKLGLNEHIGDVLLTIAKCLIALGKRRQAAYFIILGSVLTINQSSFKLFYEQIDVAMNQERSETATDQDACLAIDSSPDPTSSNDMINKFVVKLEHATNVETWEMIVNGIIEDQKKPVAIEKKENEEPVDMMDLIFSMSSRMDDQRTELSAARFIPPRPVSSASKKTTKSHRILPGLRANWTKVQSMKFDGHTMNRILKRSKKSKSSLDSTNSIQGDDTRSDDVTMTSK
The following text describes a protein:
Function:
Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Membrane; Multi-pass membrane protein.
Sequence:
MLPLSHKDNLHRGFGSRIKEKLNGWMRLIFSDRNSRNLFLFLLLNLSFAFVELVYGVWSNSLGLISDSFHMFFDCTGLLAGLAASVITKWKANEKYSYGYVRAEVLAGFVNGLFLLFISFFIMSEAVERAIEPPEVKHERLFLVSVLGLLVNLVGIYAFQHGHGHSHGGGGHGHSHGHNHNSHGHSHDHTLDIDIAASGNSQIMKGVFLHILADTLGSVGVIISAVLMQMFGWMIADPICSMFIAILIALSVLALIKDSVVILMQRQPYALDNVLPQCYQKVVSLPGVYSVQEPHFWTLCSEVYVGALKLEVSKNVDPKYVVSHTQMIFASVGVRQIYVQLDYTPM
The following text describes a protein:
Function:
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Subcellular Localization:
Secreted.
Sequence:
MSQREGSLEDHQTDSSISFLPHLEAKIRQTHNLARLLTKYAEQLLEEYVQQQGEPFGLPGFSPPRLPLAGLSGPAPSHAGLPVSERLRQDAAALSVLPALLDAVRRRQAELNPRAPRLLRSLEDAARQVRALGAAVETVLAALGAAARGPGPEPVTVATLFTANSTAGIFSAKVLGFHVCGLYGEWVSRTEGDLGQLVPGGVA
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MANSSADSSSLDQLFAQLKRFADEGDYNKADPVIKKILKEAPQDKDALLCRLCSLIQQGKYDNALTFIKSKRDLLSGVDLTFQESYCYYRLHKTKTALELLQSQANPNDKCKELLAQVLYRLENYKECITVYRNLIKNSQDDFENERETNLAAACALLSIHDRNLREDTYELRYNAACNLLSRGQIKETINKLNEAEELCRRSYDDDADVTEEEIEDELGVVRPTDTTLVAVASNNVITINKDKDVFDSKKKIKALAAEGLRHKLTSSQLKSMELNKCLLHIYANQPEQFQESLQHLIKSHDMHEMADILRSFRSVKEKNFENAISILQNMIKESSNITEKGFLTLAQLYLMQGNKQMAIETLKKMKDNHRLGIIATVVALLTNLGEAHSASKLMDENTQHWYKEAQGSELPPQLFVALKENANLKLQLGKPEDAVASLESLRKLSKELPDVETEVDIDVDNLEMAQHLYSARQAKRMVKVGTDAGDSDLKPIIVRKKRKARKRKGKLPKNFDATKQPDPERWLPRRERSYYKKRKRAPIGKGGSQGSTASSAGYDASATAAAATSQNKTAPVAEATKQQEKPTAAQPVKKPVKKPVKKKKGKGW
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MSFDTGRVYSTQVLPGDDDRVEDTNVGLTRKYADFIREFYIDGNFIYRDQLQDNILGGILTIEVDIAHVRAYDGDLGQRLADDPTGMLNLFQLAAANVARRLINPYMDEADERLRKEGPDAIAKVPYVQVTLRSDASITQIRDLGSTHVSRLVRVPGIIIGSGSVSNKVKTVTLICSHCKDQIKIEVTPGFASLNIPRACQGPPNPNGEAKNCPLDPYKILHEKSEFVDQQVLKMQEAPEMVPVGEMPRHVIICADGYLANRVVPGTRIMAIGVYAIYSAQKGKNNNKAGVKGAVAIKSPYIRLVGMTGLDSNNAPVADGLNPSREVIFSEAEEQMMITLSKEPDLYEKITGSIAPSIYGNTDVKKAIACLLVGGSKKLLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAIYTSGKGSSAAGLTASVQRESGSREFYLEGGAMVLADGGVVCIDEFDKMRDDDRVAIHEAMEQQTISIAKAGITTVLNSRTAVLAAANPIFGRYDDMKSPGENIDFQTTILSRFDMIFLIKDDHNASRDATIAKHVMAIHETGNKTEEEGEIPLDLLKRYISYCRQKVAPVLSDEASERLSGHFVELRRQVAAAERQMGRKSSIPITVRQLEAIVRITEALAKLELQPVASAAHVEEAIRLFNASTMDAVTQGTSGKDTIMEEVTQIDQELRRRLPMGWSTSYSRLVTEFVNTRNHSQEALDRTLHALERSEVIQFRMQRQRVYRVGV
The following text describes a protein:
Function:
Can complement TBR and is therefore functionally equivalent, but may work in different tissue. May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Miscellaneous:
MISCELLANEOUS: Contains 2 motifs that are conserved in esterases, but it is unlikely that this protein belongs to the catalytically active pectin esterases.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MALDSVKHLPIHGVSAFSSVTVEIKSFFSTVKPRKTSTFVYAFVVTFVALTVFLAFSPSPITVALAPSISSYVLPNITVSNSSNSSPSSLDSNFTTLRTPAPENLTAVTKNLTFESPVANGTTDTNAKTITIQFQTGHAKENISCPDNKTARDLDTHGARKAPLSEVLAVNSTASPKRKQRRKSSLRKVIESLKSCEFFEGDWVKDDSYPLYKPGSCNLIDEQFNCISNGRPDVDFQKLKWKPKQCSLPRLNGGKLLEMIRGRRLVFVGDSLNRNMWESLVCILKGSVKDESQVFEAHGRHQFRWEAEYSFVFKDYNCTVEFFASPFLVQEWEVTEKNGTKKETLRLDLVGKSSEQYKGADILVFNTGHWWTHEKTSKGEDYYQEGSTVHPKLDVDEAFRKALTTWGRWVDKNVNPKKSLVFFRGYSPSHFSGGQWNAGGACDDETEPIKNETYLTPYMLKMEILERVLRGMKTPVTYLNITRLTDYRKDAHPSIYRKQKLSAEESKSPLLYQDCSHWCLPGVPDSWNEIFYAELLVKLDQLGGKRRRKALKDHRS
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MWEFSVGLYMINIWPDSSLYAAIYGTIESASTALFDPIIGRWVDKLSYVKVLKLWLVTQNLSFVIAGATVIAYLSTQSLKFTNFPAFILLVNPPELLTKMNSVTRRIDLTCKLLAPVVTGFIISFVSLKASALTLALWNTVSVWVEYWLFTSVYKGIPALGLSSQRRMERPSQIYLKEEVALPGLALALLFFTEYLHVIGIARGISAGIEIAATVVYPVLQSQISTIRTGLWSIWSQLEYGQSGFLSSYILMGSVAIYRLGLWMFDLSDLVPESDRLIVGGVQNSLQSLMDLLAYVMGIIISNPRVICSFLEVTLAAFLYCIHVYHVRKHIFHFERLKWS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MKLTPASILEAPVYYADHIHGKYDVDKVVILRDCGYVSENEIMPQTLKLLPERTNIVDFTNNELEELPPLGHNDTVHTLLLSRNRLGRLDASRLPRYLVNLNLAMNRFEKFEQLQGLRSAPKTLKNLNLRGNVICHKEQYRETVIALCPQLAVLDGERVRQAERQAAPQNEKTDTPTEGPQPVALQATSEKELQLMDHVVNKMDKDTLEDIKQQLAKATTLAEIERLEKLLSGGVIQ