lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEYDLTQKTLPFLDRHLIYPLLQFLKGRGVYNDTELLQLEYDLLKDTNMTDYLVELSKELGQNDADLQAKKENVVKTLAELEEATKPVFEVLENPEVVSELKENKTQNQALLTSKYGLSVEQINLLYKFGQFQYNAGRYQAASDILYHFRALSTDPELVASATWGRFACEILTSQWDSVLEELGKLRDSVDSRSLDPQQQLHQRMWVIHWSLFPFFQNDTKGKDALCDLFFSSSYISTIQAACPWILRYLVVAVIAGGHPHTASVFQKRLKDLVRVVGQEEYEYQDPLTRFVKSLYIDYSFEDAQNQLADCEKVLKQDFFLADSADAFLESARKLMSQVYCRVHQRVDIAQLSQTLNLSQEQGEKWIANLIKDSRMDAKIDESDSTVILNHPSVSVYQQVIEKTKGLTFRSSQVLNQGVTI
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MVGARAGRVPAAAAAAAAVLIVAACVFSSLAGAAAAAEVVGGAAQGNTERISGSAGDVLEDNPVGRLKVFVYDLPSKYNKRIVAKDPRCLNHMFAAEIFMHRFLLSSAVRTLNPEQADWFYAPVYTTCDLTHAGLPLPFKSPRMMRSAIQFLSRKWPFWNRTDGADHFFVVPHDFGACFHYQEEKAIERGILPLLRRATLVQTFGQKNHVCLKEGSITIPPYAPPQKMQAHLIPPDTPRSIFVYFRGLFYDNGNDPEGGYYARGARASLWENFKNNPLFDISTEHPATYYEDMQRSVFCLCPLGWAPWSPRLVEAVVFGCIPVIIADDIVLPFADAIPWDEIGVFVDEEDVPRLDSILTSIPIDDILRKQRLLANPSMKQAMLFPQPAQPRDAFHQILNGLARKLPHPDSVYLKPGEKHLNWTAGPVADLKPWK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MRKPKSKSRELRKQRKFAEQEEVSLLNEWIESQKPDSGSNTLALPPLPSNAPVGRLSDGTFSRYAGSTKFSELPMSKKTLDGLKKSDYVSMTEIQRASLPHALCGRDILGAAKTGSGKTLAFVIPVLEKLHRERWGHEDGVGSIIISPTRELAGQLFDVLKAVGRYHNFSAGLLIGGRKEIDTEKERVNELNILVCTPGRLLQHMDETLNFDCSQVQVLVLDEADRILDVGFKKTLNAIISQLPKHRQTLLFSATQTKSIQDLARLSLKDPEYVGVHEKSTTSTPDRLQQTAMVVPLEQKLDMLWSFIKAHLNSKILVFLSSCKQFCEKRSVLFSTDVASRGLDFNKAVDWVVQVDCPEDVASYIHRVGRTARYVSGGRSVLFLMPSEMKMLEKLQAAKVPIQFIKANNKRLQPVSGLFSALLVKDSDLQDLAKRAFVTYLRSIHIQKDKEVFDVMKLPIDEFSASMGLPMTPKLRFLNQKIKGKMMSGIQLDNADKDIASLATGAFREEDLEGQREELDIGDSGEADVEKGFLLSKETEHEGEEKTSELGPILPGTRVLKKKKLKINIHRPVGTRVVFDEEGNTLPPLARVADGKNVDNSSLLDQGKREEYYKKMREDLKQADKEDKALDRQRRREKRIKEKMKRKKQTSDSEEDRDEEEDVSASEGERMGDRKPKRSKIYFDSDSDDGKTTEDREKLVKTDSISLAEQEALALKLLSTMH
The following text describes a protein:
Function:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Subcellular Localization:
Nucleus.
Sequence:
MFSSANRMTNLRPCWLGLVLVPGARRVLRSNRRRQGCQRGVMEAVLGQVAELPALLAVSRSALVRDWDPPTLDRALEWARYFQHLHDRFRSRPQLRDALRRRLRRGEAGSPLSFRHLGGCSELLGLALLENRALPPAACRRLLQRLLQGEAGFELGRLAPLARRKAASYLLEGSALFPGKPGPRVCAEAGLLLCRLREDGREAGAALGWLGPVLEQLPQPRAFAVVAEALLRQGCGGGDGDSSAGGQAGGAEAGSVAGALLSWLLEDLHRFSACSLLLPGTLLASLAGRYAQLSRRYLDLLAEWGSHLLYDPLQGRWVKSRSEEAKLCWEELRERFGCLCQGSVQLREQTQAALKLLKARDGDFQVCGLSVWTDLLLEVEEDLRKKQSPNV
The following text describes a protein:
Function:
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.
Subcellular Localization:
Nucleus.
Sequence:
MDSSLFSLKNSFGGFNDEELLRVQKIIEDLELTESIVSKEWVTFALQKKIAEDYSKHLDPFKVFLKKNIKKLKVQKTTEQIKEVAEEDPKMFENVEIEDIIFDTDSLVDESEIPKIKDEPSSSVDVSTARNKNNHNNNNNNNPSLPNKSMFKPTKQEMTNDNIKKVVIADDIGDFDFTTANQPIKQSNPTQLLNYKERKNIGGISYSMNNNEELKTDLSLREKKSCDLKGAGEEFYPIKYHRDTLEQRTKILKESVQSNNYTFPVSLDCQDDESIVRSVGRVWMYDQETILSKRFYLLGNERDSSSSGGSSGSASIFSLENNIPDYSMFSGQVVMAESKKIAGSHFYYTNKLYTPNPLPFFSQRKECGDINVMIASGPFDLQKSTPDYTPLDDLCNVVSNKKPHILFLMGPFIDESNVHIKKYSETFSELFNNLMKKLNDNIPSTTKVLIVPSLNDVDHEYIFPQPPYVPSVNLNSNILFVPNPFTLIINESFTIGITSSDIYNNLVSKAHFKNKHTPEDIFNMIINQNNYYPMHPAQAPISMRYLQHLNFPGFTPDILVVPKNSPIAAISNDVLCLGVPPIVGNKSTFGSYAELTVTKSKQSLAFDNNIPVSKRTIVNFKNI
The following text describes a protein:
Function:
Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MTDALSNATLAGAREHTLAVTRDYISQPRLTYQTVSGVNGPLVILDKVKFAKYAEIVTLNLADGTQRSGQVLEVSGEKAIVQVFEGTSGIDAKYTTCEFTGDILRIPTSEDMLGRIFNGSGKPIDKGPSVLPEDYLDIQGQPINPESRIYPEEMIQTGISAIDVMNSIARGQKIPIFSANGLPHNEIAAQICRQGGLVKMPDKSVLDGHDDNFAIVFAAMGVNMEAARFFKSDFEQHGSMDNVCLFLNLANDPTIERIITPRIALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVSGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYIDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHSDVSNQLYANYAIGKDVQAMKAVVGEEALTQDDMLYLEFLTKFEKSFIAQGSYENRTVFDSLDIGWELLRIFPKEMLKRIPRNVINEYYPRKKPAVPTK
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRFNTISEKMDQYISPLANKLSQQRHLKATRDAFMSMLPITLFGSIPIILKAAPVTDDTKNGFLLAWANFAEKYDLILNWISGITLGAMSLYICVGITYYLCKHYHEDFLRPLMFSIAGFFMLVLNPIKMGWDGKEVDISFLDGRGILLSIFVAIVTVEGYHWMRKKNVGRITMPDSVPASLSETFAALVPGIILMTFFSIIFIIFNLLDTTAIQFLYEKMAPSFKAADSLPFTILSIFLVHLFWFFGVHDAALAGILGPIRDGNLSINAAEKMAGQDLTNIFTTPFWTYFVIIGGSGSVLALAFLMMRSKSKQLSTVGKVGFLPSIFGISEPLIFGTPLMLNPIFFFPFIFTSVFNGVITYLCMYFGIVGKTFAVFSWQMPAPIGAFLSTMDWRAIVLVFILIFLNGLMYYPFLKVYEKNLVALEKEAEEENIAAN
The following text describes a protein:
Function:
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYNELLENLAILVLSGFVGFAVISKVPNTLHTPLMSGTNAIHGIVVLGALVVFGEIEHPSLVLQVILFVAVVFGTLNVIGGFIVTDRMLGMFKAKKPAVPAKPDRDEALR
The following text describes a protein:
Function:
Required in an early step of flagellar assembly.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKVSSTGGVSATGASRAKPAGGSSGFSLPSVNAASGAASTASVGGLTGVGSVDALLALQAAGSVGGPLERRKRAVRRADNILDILGEVRIALIDGDISHATLDRLSRAIREQREATDDPRLEGVLNEIETRAAVELAKLQARAG
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase.
Subcellular Localization:
Cytoplasm.
Sequence:
MGSKGKKGKSSEVNLETSKNKEKNIKGKKKNSLDPIEKNKQETAGLQTTSRPTAKQLVGGSSWTGKIPVVLLNEHCQRSKWEKSDVKVRQTKSKNYIFTSVVLAKKDPKNPSILDHVSLIPPKSYYENGYFPEKETLVEARNVGAVYALHRIMSHKSLQHALPPEHRNIWFDMEKQKKEELKNKHSWLYNEDPFKAAKELQAARASSAAKPPPKASQKNEKVSLTSIKNTSLSHFSKFNFKYALPIHMSLENRRSLENLFRNMNTWDILEDTKNLEPDTSIVNDLISLGFRDIHAKEACQYCVSLEDALEWLIIHVPEDDLPTRFLPSDYTTGISVQNLNSANLAIHYNAKRISETGYSFDLCFSTLQTFENNIQISSEYLQQHLIGESFDGNISLEPNSTEWDDDVSALQSILDNKVSKIENGCRVRIDYPTSEFGELFVDFRRPARSYPAHIPLMSLSSTKRMASYIKLSILKKMVVYAMDLRGECMLSWLYNHLQENIEDFLQNIGSLLNISAATIGVSLSSQNKSAPTAKKNNSFKPKLFRRSRELSEKLCNNWSERVKSPSYQLKVREREKLPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKDLQTVVCTQPRRISAISLAERVAFERDTTVGKEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYIEDFAPKLNEDDDEEDVPRRKKKEYEIDYHLISRLVSSIDAELGSSSGSILVFLPGVSNIARCIREIKSKDGSKFEVLPLHASLNTSEQRRCFKTYTKRKIICATNIAETSITIDDVVAVIDSGRVKQIDYDVERDLVTFKETWASRAACQQRRGRAGRVKKGICYKLYTRGFEEKGMLGQTPPEVLRTALSQVCLNVVPLVKRFSSAGNSVNQGSIKKFMNSLIDPPNDATVDLALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYLEPALTITAILSTKSPFLGDDEAREIRSKQSQGWGDVLADARVYHNWLEILETRGVKKTVQWCEEMHLHYTTLQQIRQNRNELSEAAQLLELTTKKLTGNFDWYSTENLTVLSTLIAAALSPNVVKCVYPDKKFVASFSGSLEMEQEARLTKFYDQNNQRLFIHPSSTMFVNSPNASRCTFVAYEQKVETTKPFLRNCTPINTYGMILLGANDILIDPLGKGLILDQAYCIKAWPKVVILLKMLKRCLDASLHERLESSSGLNYESEIHQCIRTLIAGNGV
The following text describes a protein:
Function:
May act as a transcriptional activator.
Sequence:
MNKAKNSGAVPQFVDNFEDFYNNGDDILNNKHKEEINFVKYRIFDTHLINYNNNNNNKNNNNNNNNNENTTITNKLNEIKEYLILNYIKDYIWQKEPFNLKIYDHKKKQQQQQQLPIHFYGNTKFEESIDDEWFIVYILLELTKKFQSLIVSIKDNDGEFILIETAQALPKWIKPTNSNNRVYLKNGEIHIIPLPSDPSQLDTIPYKMDTNTALSILSSSSNNIITKVSNEINEILKNRLKRFYNGEYFLKDQNQIKLAAIPIEIGYLLNQYPQLISDITTTFYNRDSDDMKTISTMKRFPMSRERDSFGNSGQLITTNIRFTRCLYAMLKLQQWNSPKNFHPQLPKPSHPTYDSRSLGVKIICGLEMVYNRSKRNSVSSYHRFNDDLNWLNYLKQLKSNNYFNDETIGSKLYKEKLLIAKNQYLKNNINNNNNNNNKEEESIYKLIDQVTNSKSVDEMIKILQESDKSKIESEDDWLNEENPDKFEDLITEFENDRQKQQQKQQQQQQQQQQNKEGKKEVKENNNNNNNNNNNNNNNNNNNNNNNNNNNNDSNLINDFSNQFKSMLSQLSSFDGVEFNEKSGNSKNKTKSSAYGNGGDDNISFDSNKFMDILKGFTDNNKYDDDYDDDDDDDDDMYQDIDNYEDSDDKDDDEDDENDEDDEDDGFEEYEDEDEDDDDEKEFQYVEFLKKSTIKQYMERMDQELNLKIIASSFELESTKLPKEFDDIEKSNNNNNNNINNNDKDVDEDDNENYKVNQKVDLNLNLVKNLLESLTEQQGFAGPASTLLKEMSDNNSKKREKKKTSSKKLIPKKGKVKENK
The following text describes a protein:
Function:
During fertilization, required for the formation of intercellular membrane pores and subsequent exchange of gametic pronuclei between cells. Probably initiates the formation of intercellular membrane pores by inserting part of its extracellular domain into the cell membrane of the adjoining cell in the mating pair. Mating requires the presence of HAP2 on at least one of the two cells. Mating efficiency is high when HAP2 is present on both cells, and is strongly reduced when HAP2 is present on only one of the two cells.
Miscellaneous:
MISCELLANEOUS: HAP2/GCS1 family members mediate membrane fusion between gametes in a broad range of eukaryotes, ranging from algae and higher plants to protozoans and cnidaria, suggesting they are derived from an ancestral gamete fusogen. They function similar to viral fusogens, by inserting part of their extracellular domain into the lipid bilayer of an adjoining cell.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Detected at the mating junction.
Domain:
The region that is important for membrane fusion binds to lipids and can insert itself into lipid membranes. It is unstructured in an aqueous environment and assumes a more ordered, beta-stranded conformation in the presence of lipid membranes.
Sequence:
MKFLAFGLIYFHFCILNRCEYITSSTIQKCYNSSNEPNNCSQKAVIVLSLENGQIANTEQVVATLNQLSDSGVNKQLQNSFIFEVTKSPVTALFPLIYLQDFNSQPLEQVIATTLFSCKDGFYDSSPTCKFQYDSKGQKILDSQGYCCYCSLSDILGMGNDLSRGKVCYALNLGAGSATAHCLKFSPLWYSAFKIQQYQLYFEVNINIYTVDSQNQKNLKQTLKLSTSNPTMKSSDNSTISKIIGTFTPTQPPADLSSYYLVKPSFPATDPRVLQGISSWMFVDKTMFTLDGTQCNKIGVSYSGFRQQSSSCSQPVGSCLQNQLENLYQSDLILLSQNKQPKYLLESQGNFNQVQFQGQTILQQGLSGSASTLITIEIDAAQIKFVTNLGIGCISQCSINNFESHSGNGKLVALVQNQGNYSAEFVLGFNCSSNVQPIQGQKLFLTANQLYNFNCSVSVNSDISAINNNCTINLYDAIGNQLDSKNILFNTTSTNHTSNQGNNTGQQQSSQEYKSSQSCSDKCSSFWSFWCYFSAGCIKEAFKSIASIAGVASALALVIFLAKNGYLVPIIRFLCCCCCKSKKKENEKNKDKTDKKSIQESCSYDRSCCSHSISQSYQVENKNKYKRSKIQRSFSSESCQDKSKKIINELSNLEETFEANKLYANIDKNSSIFEYFGFKKSFTFILYERNDILFLPQNSTILDMIGALQPQKGSYLAQKFLEIVNKNALKVVSTSPLYLLIE
The following text describes a protein:
Function:
Soluble adhesin with carbohydrate-binding activity. Binds to galactose-terminating oligosaccharides. Required for attachment of the parasite to the host cell prior to invasion. Triggers the activation of murine bone marrow-derived dendritic cells and macrophages and production of pro-inflammatory cytokines, such as IL12 (IL12B/IL12A), in host TLR2/TLR4-dependent manner. Triggers the production of anti-inflammatory cytokine IL10 in murine bone marrow-derived macrophages in host TLR4-dependent manner. Induces transient endotoxin tolerance in murine bone marrow-derived macrophages, manifested by reduced TNF-alpha (TNF) production in response to challenge with lipopolysaccharides (LPS).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, microneme. Host early endosome. Note=Localizes to host early endosomes after interacting with host TLR4.
Domain:
The first and second apple domains are sufficient for targeting the protein to the micronemes; C-terminus encompassing the sixth apple domain is responsible for host cell binding; The fifth apple domain is a lectin with specificity for galactose-terminating oligosaccharides.
Sequence:
MRASLPVHLVVCTQLSAVWFGVAKAHGGHRLEPHVPGFLQGFTDITPAGDDVSANVTSSEPAKLDLSCVHSDNKGSRAPTIGEPVPDVSLEQCAAQCKAVDGCTHFTYNDDSKMCHVKEGKPDLYDLTGGKTASRSCDRSCFEQHVSYEGAPDVMTAMVTSQSADCQAACAADPSCEIFTYNEHDQKCTFKGRGFSAFKERGVLGVTSGPKQFCDEGGKLTQEEMEDQISGCIQLSDVGSMTADLEEPMEADSVGACMERCRCDGRCTHFTFNDNTRMCYLKGDKMQLYSSPGDRTGPKSCDSSCFSNGVSYVDDPATDVETVFEISHPIYCQVICAANPLCTVFQWYASEAKCVVKRKGFYKHRKTGVTGVTVGPREFCDFGGSIRDREEADAVGSDDGLNAEATMANSPDFHDEVECVHTGNIGSKAQTIGEVKRASSLSECRARCQAEKECSHYTYNVKSGLCYPKRGKPQFYKYLGDMTGSRTCDTSCLRRGVDYSQGPEVGKPWYSTLPTDCQVACDAEDACLVFTWDSATSRCYLIGSGFSAHRRNDVDGVVSGPYTFCDNGENLQVLEAKDTE
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
Subcellular Localization:
Cytoplasm.
Sequence:
MIRSIFDSEKNCQILLLVNSVVEFETRFRMISSKRTAFPGITAFPGKLYGKVLKTGKRRNTILTGTYVHESEKEAEVEKFSVALEESLHSLRILITSLETSGPDQKEIQEILETQAMICSDPSLATSVRKRILELGENAILAVQNVTHEISEKFKAMENEFFRERVDHFQDVSNRLIEFIAGKKEEEDSFLSGLKEDLILVARELTPSQMILMDKTRIRGIATDLGGKTGHMAILARNYGIPTIVGLKDFSSHVKDNEFIFLDAESGNAIRFPTLEEVKYYGFSSSYPTEENETKKIRAITKDGIRVRIKCNLETELDCEQAIKSGAEGVGLFRSESLFLKYQDSNVSGEEQFLAYKAIAEGMQDKPVIIRTFDIGADKFSTGELEENPFLGNRGIRYSLSNPEWYSEQLTAILRASAFGNVSILLPMITGPVEITRTRKLLEECKRKLSAKKERYNKKIKIGAMIETPAAVAALDLIAREADFFSIGTNDLLQYIMAVDRNNIHVSSLYNPYHISFLRALIRIVEVSRDYDKPLSLCGELASDTDFTIFLVGIGIRELSVSIPFLSPIRKIIRSISLHQAGILVKKILELSEQENYESIEAFLFSKHLS
The following text describes a protein:
Function:
Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass type II membrane protein.
Sequence:
MPWSKFTKVALGLGAAIAAVRSTMFTVDGGQRAVMFHRFEGILEEPVGEGTHRKIPWVQKPYIFDIRTKPYKINTDSGTKDLQMVNLTLRVMFRPDVVKAVVAQFNADELLTERPQVSALIRETLIKRAKEFNIVLDDVSITGLSYGKEFSLAVERKQVAQQEAERSKFVVAKADQERRAAVIRAEGESEAARVISKATAGAGMGLIKLRRVEAAREVAITLSNSPNVVYLPSGGNMLFAMNGPSKVVA
The following text describes a protein:
Function:
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSAKGDKLAPRPPSYGSNQSATPTYSLPPHPSTTYPQRHQSPASHAAASTLAALASSPPASSSTASPHPPNVLPTPSSASTSYNARPSTTSTLNQSLYSSSASPAAKAATAGISPSGSPLRKEVHMSSTKQTPAASTSTLAKPASSSTTGTPTPSSASKESGSSKRKKATRACLHCQKAHLTCDDSRPCQRCVKKGLAESCMDGRRKKAKYLLDDDELEELRRQKEAKKAAKQAVQQKNAPSPQQRQSRPSQQDSAKSTPQNSDPSSEKASAVSSILDQVAGSIATPSSSGHGPSPHAHDYLSSNPFDSSNGGVDDTQASSNNGGALPFDLSFDPSTHNFGSEATSLEYSILSSMLNGTDLQLMGASGASPDLQASPAVGVMNGWNIASGELDAILNISMQQNQVPGAGGMDTVAATYSDTADMGVYADPQPNTGLQDVGGGDSALNALEVPSSQCTAKEEPILLSSGSGNGNGNGSGSGSGEAQQAGSNNQVDLGSSSQRSTSNEPVAADINRAIASRRVARQQQDTIWRARIAKTYRDNTAPFPYPEGYHFLIKYVTSKYEKQDVLRIVRALAIFRPSLIALQMPLTEEDEIFVERSFQRTMLEFEKLISFSGTPTVVWRRTCEICVVGAEFCMLTQWSKDQLMGRRIYEFMDKNSTLDYWENFAQHAFENTTQSVMTTCTLVKPDGKLVPCAWSFTIKRDIFDLPSLVVGNFLPILS
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSTSAILFSGLPNSSEGTQAITFHELSTSSQVHQLKSPANAAFGLSSTVQNAGLPPRKTLACLPSTNSLGSTVLTISGKDGRNGILLWSTLAGKPTPSHRLIPPGRVIVVALSPSGTYLASGSADGVIMLWELSTGTLLASFDGHYKSVTCLAFSDDEAALVSASEDSMCSVWSIPTLIDEAFDSNLSHTPYSIFSDHTLPISDLFISKGCFPDLRIFTASLDQTIKIWSPLYPSSPLLSTFAVPGPAHHLAVDPLERFIIVSYATMLKNESQEPQQANGTASQPQQSNTIPASTLKIIPLFSRPSHAAPQGGVSRVHGPSGLVQRTESGNEEVSYTSPRSTQITALHLPSPIVSSSVVLCGLSNGKVVHLSMPSLQPLGQTVPHPNAAGEAKDPVVYLSTFARPADLLSSSVADALSGPDHSGSSSVSPRPVGVLGRVIGKNGDPQRGSVPLQAGQPQRACRELCTMLKIEQVDEHALNQDDPFSLPSREPRPDSTSSALHSLPDHSLVHSHQAAVGDHQLKSQTDSIEKLTAETVHLKAQLKQALAFNDSLWAGIVDGTLAFKESALPPS
The following text describes a protein:
Function:
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function; Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
Domain:
The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.
Sequence:
MKKFVCSNCGYVSPKWFGRCPQCGEYDTAEEVQRRKNREGSPSLFLNLEDAGEISLERLSTGFSELDRAFRGGIVPGQVILLSGEPGIGKSTIALQIAERFAERGLVVYVSGEESPQQLKLRADRLLLKRKKDILLTLENDIDEIISSLQNKRVSFMVVDSIQTVFSSDLGSSPGSISQVKNVTMKTIDFAKRRGVPVLLVGHVTKEGEIAGPKLVEHMVDTVAYFEGDRRTGLRLLKITKNRFGPSDEVAVFELKENGFVQVENPSFTEGDADLPGNVLTCVFEGTKPFVVQIQALVSKNRTFSPKRVCKGVDVNRVMLLIAVISKYLKLPIETHDVYVNVVGGLRVTDPAADLAIALSIVSSYLEVSLHNTAAVGEIGLDGRVRKVYNINRRLNSLKSSGRIIVPPIEEEQKGVFEVRDLKEAVSIIGGEILGTPGAD
The following text describes a protein:
Function:
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA. Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631. Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation.
Miscellaneous:
MISCELLANEOUS: Present with 26900 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKYTIDELFQLKPSLTLEVNFDAVEFRAIIEKVKQLQHLKEEEFNSHHVGHFGRRRSSHHHGRPKIKHNKPKVTTDSDGWCTFEAKKKGSGEDDEEETETTPTSTVPVATIAQETLKVKPNNKNISSNRPADTRDIVADKPILGFNAFAALESEDEDDEA
The following text describes a protein:
Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MVRYCVRSLSERSHEVYGQQLHGQEQGHHDQEEQGLSPEQVEVYERTQGHSHYRRRHCSRRRLHRIHRQQHRSCKRRRRHSCRHRRKHRRGCRTRRRTCRRH
The following text describes a protein:
Function:
Positive regulator of transcriptional elongation that is essential for cells to initiate differentiation. Interacts with RNA polymerase II and the Elongator complex and is required to sustain global levels of transcriptional elongation activity, specifically in differentiating tissues.
Miscellaneous:
MISCELLANEOUS: Over-expression of IYO activates premature cell differentiation and confers resistance to the elongation inhibitor 6-azauracil.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic in undifferentiated cells (meristem core) and nuclear in differentiating cells.
Sequence:
MEQSSGRVNPEQPNNVLASLVGSIVEKGISENKPPSKPLPPRPSLLSFPVARHRSHGPHLAPVGSSIAQPKDYNDDQEEEEAEERFMNADSIAAFAKPLQRKEKKDMDLGRWKDMVSGDDPASTHVPQQSRKLKIIETRPPYVASADAATTSSNTLLAARASDQREFVSDKAPFIKNLGTKERVPLNASPPLAVSNGLGTRHASSSLESDIDVENHAKLQTMSPDEIAEAQAELLDKMDPALLSILKKRGEAKLKKRKHSVQGVSITDETAKNSRTEGHFVTPKVMAIPKEKSVVQKPGIAQGFVWDAWTERVEAARDLRFSFDGNVVEEDVVSPAETGGKWSGVESAAERDFLRTEGDPGAAGYTIKEAIALARSVIPGQRCLALHLLASVLDKALNKLCQSRIGYAREEKDKSTDWEAIWAYALGPEPELVLALRMALDDNHASVVIACVKVIQCLLSCSLNENFFNILENMGPHGKDIFTASVFRSKPEIDLGFLRGCYWKYSAKPSNIVAFREEILDDGTEDTDTIQKDVFVAGQDVAAGLVRMDILPRIYHLLETEPTAALEDSIISVTIAIARHSPKCTTAILKYPKFVQTIVKRFQLNKRMDVLSSQINSVRLLKVLARYDQSTCMEFVKNGTFNAVTWHLFQFTSSLDSWVKLGKQNCKLSSTLMVEQLRFWKVCIHSGCCVSRFPELFPALCLWLSCPSFEKLREKNLISEFTSVSNEAYLVLEAFAETLPNMYSQNIPRNESGTWDWSYVSPMIDSALSWITLAPQLLKWEKGIESVSVSTTTLLWLYSGVMRTISKVLEKISAEGEEEPLPWLPEFVPKIGLAIIKHKLLSFSVADVSRFGKDSSRCSSFMEYLCFLRERSQDDELALASVNCLHGLTRTIVSIQNLIESARSKMKAPHQVSISTGDESVLANGILAESLAELTSVSCSFRDSVSSEWPIVQSIELHKRGGLAPGVGLGWGASGGGFWSTRVLLAQAGAGLLSLFLNISLSDSQNDQGSVGFMDKVNSALAMCLIAGPRDYLLVERAFEYVLRPHALEHLACCIKSNKKNISFEWECSEGDYHRMSSMLASHFRHRWLQQKGRSIAEEGVSGVRKGTVGLETIHEDGEMSNSSTQDKKSDSSTIEWAHQRMPLPPHWFLSAISAVHSGKTSTGPPESTELLEVAKAGVFFLAGLESSSGFGSLPSPVVSVPLVWKFHALSTVLLVGMDIIEDKNTRNLYNYLQELYGQFLDEARLNHRDTELLRFKSDIHENYSTFLEMVVEQYAAVSYGDVVYGRQVSVYLHQCVEHSVRLSAWTVLSNARVLELLPSLDKCLGEADGYLEPVEENEAVLEAYLKSWTCGALDRAATRGSVAYTLVVHHFSSLVFCNQAKDKVSLRNKIVKTLVRDLSRKRHREGMMLDLLRYKKGSANAMEEEVIAAETEKRMEVLKEGCEGNSTLLLELEKLKSAALCGRR
The following text describes a protein:
Function:
Catalyzes the exchange of ADP and ATP across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLAAAVAGGITQTAVAPIERVKVLLQTQDGNRQVLLSGKRYTGIIDCVRRVIREQGFLSLWRGNGADMMRHVPTSQLNFAFRDLYRDLLGKYDKQNDFYKFFGANLLAGAGAGATALSITYPLDFAHTRLAADVGYGTAGRQFSGVKNVISTIYRSDGLRGLYKGFGASIQGIIVHRALYFGMYDSFKDLYIDDNEPGALYKKWGIAQAVSTTSGLVAYPFNTVRHRMMMQSGDLDAMYKSTLDCWRTIFRVEGVRGFYKGALSGVMRSTGAAWVLVLYDEFKKRFH
The following text describes a protein:
Function:
Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (By similarity).
Subcellular Localization:
Cytoplasm. Midbody. Lipid droplet. Note=Transiently associated with endosomes. Colocalized with IST1 to the ends of Flemming bodies during cytokinesis.
Domain:
The senescence domain is required and sufficient for lipid transfer.
Sequence:
MEREPENGEPAEIKIIKEAYEKAFMFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISIAAAEPGHTGPAWEAARQMQQKMKETLQNVRTRLEILEKGLATSLRNDLQDVPKLYPEFPPKDACKKSPEQESVSTAPQRAEVDGSASAACAGPSGAPSALPVPSPSCPAEAPPAYSPQAAEGHYTVSYGTDSGEFSSVGEDFYRNRSQPPPLETLGLDADELILIPNGVQIFFVNPAGEVSAPSYPGYLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTVGAYMFPDTMLQAAGCFVGVVLSSELPEDDRELFEDLLRQMSDLRLQANWNREEDEFQIPGRSSHPSEPPKEASGTDVRQSSSSGSSIDQGSKDARHKGKRGKKTKDSSEEVNLSQIVPCEPSSEEKSKELPEWSEKVAHNILSGASWVSWGLVKGAEFTGKAIQKGASKLRERIQPEEKPVEVSPAVTRGLYIAKQATGGAAKVSQLLVDGVCTVANCVGKELAPHVKKHGSKLVPESLKRDKDGKSALDGAMVVAASSVQGFSTVWQGLECAAKCIVNNVSAETVQTVRYKYGHNAGEATHNAVDSAINVGLTAYNIDNIGIKAMVKKTAKQTGHTLLEDYQIVERPQRESQGGATSTEGRRDIGKQVEEEKPGAGKKDK
The following text describes a protein:
Function:
Required during early processes in pollen development.
Subcellular Localization:
Nucleus.
Sequence:
MDSKNGINNSQKARRTPKDRHLKIGGRDRRIRIPPSVAPQLFRLTKELGFKTDGETVSWLLQNAEPAIFAATGHGVTTTSNEDIQPNRNFPSYTFNGDNISNNVFPCTVVNTGHRQMVFPVSTMTDHAPSTNYSTISDNYNSTFNGNATASDTTSAATTTATTTV