lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (By similarity). Required for axon regeneration after injury.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MRLFHFLKFLTINNFSRYCLKIVKVHIIWITIICIIYFNWRFKKLDFMAIPYPPAVIKFNTSAKYLSSNLASSSQLGNNIFEIASLYGLSKHLNRTPLFFIENGYHKKMLDNLRKTMPRLMEKFRILNGSVPRSISETKFQRACCLHKSPWSLEKNRDEYLHLSGKYYQSWKYFPNMRNELIEFLNPTSIQIFGNLPISDDQNHVTCVHSRRGDFVEYLFYASDPKFMKNAVTFLNENEKVGSRNRKIVLFGDDLNFLETYFSDAVLSTDVGKNAEYYISQNPPIDDFLYSKNNCDVVLITAPRSTFGWWIGYFSKGNKVYYLDIKYTGDHIFESGGLIASDFYPSHWTPLKFASANSFTVVRS
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MEVEVEVETDPNTSPDEATASGEPKACADCHTTKTPLWRGGPEGPKSLCNACGIRYRKRRRQALSLDAAQQQDQQPSKKAAADPQQDDQQPQPKKKPAADSQEDQQPQPKKKPAADSQEDQQLQPKKPAAAASSTTTNKKDKKKKKDRQVTVELRVVGFGKEVMLKQRRQMRRKKCMSEEERAAVLLMAMSSGVIYAS
The following text describes a protein:
Function:
Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MVVTRSARPQARNEATSVESLRQKNSAVTRLHVHPKGRKGSSPDNPNTTESQTTPERSPAPKTRKSGTTGSLPEMNKPATDGEISEAESDCSSVPEVQDPVFRVTRRRQILVAGTPVSSVRKRLKITRVSESHTEEVVSEADSHVSGISRIMPPTEITTRRSKAKSQREPKQESHVEVISDAESSCSDISFSGIATRRTTRSMQRKLQAQTEENNTKIVLENEKEIIHTPVNLEDSVNRRTSRLLARSLSQINKPNFSNNEIYNDPDDSFFGISGKKLAVKKTRNFTIREEKQDSISPLKEITKQNCKSLDEEAKKIIDGGKEGNEKNSQLNLSEFQDTGLQQLVSQRHSTPESDKTTSESSTLNHEAVMKSLAQTFAVVEMDRWNEERKNAIKTSDCSEPGDGSYSDSDEECTVIGVSEDMSKEKEVDSESDTKPSNLEFNTTQDKDDSVLLVLSSDESQQSEHSENEEDTVCFVENNGNKESLNGDSENLSHDNALFVIDTTPGLSADKNFYLDEEDKAGEVATEEEEEEEEEESEEELSDHDRNKDNEFSDEDNLLSNTKSKLLKLMSSSIDTGLNIKELGGLYINFNADKVQLNKRTLTQMKEKRKDELLQKTVITPEFEKNYCVPPYSESKYKLQKKRRQERQKTAGDGWFGMKAPELTDELKNDLKALKMRASMDPKRFYKKNDRDGFPKYFQIGTIVDNPADFYHSRVPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRKKKKFRN
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis.
Sequence:
MSTISESTRPGTDTTLAKHDLPFASVAIAQYHKIQEKLASNNIFCILRSPAPIRVWVYRSLLAENRLWNECDRPAVSATMDKDKDKESRDDGSIDDTESLRDSEADSVNGARARPHLTRLRLALAPYCVHFNNPGYIRDDTLRMLERDVVKKTLEETRKSLEMREELGLSWEFWDSLAEVLKVAIPSLERRCFAAPDPAAPEYEGLSGPLIASYSPSLLRDLERLNQLVCIARNVQVHGEKVQNLSAERLFDKDIFALINVCVRVTARGYDGEAGTQDEDKWQGVINAYKKLLITCLQFLNNLIARNEQRKLMLWIELFDSHLDNELPNFADMKYKLDEFNQQEPTWQPDTPDPMARPSRSLETFKIPQQPASSPFLLYIGETGNDVKKALQQHGVKAGANEIAAECRRRWQTMSEEEKNKWNMLYADVVARYRDQITQSSTYKKVVDQHAKNEESVQALAKSINQLQVEVDRMRSSISTSPESTSHEQASPAAEAKQPARPAPDDSLLDPSIKPSSPAGEIDFRVTYPPSFGAEILQNGKEDLLKRLEPDPDRPSGLISHVASPTSPLPEDDDDNDDDYDDIPGDEGRGLLTDVPLILGPTEIEVLPMIIMAGIVEPQEGQPGYHSDPTVFSSVRSMHGVRCHLLLAQDNGRNLLRELLIFVAAWDLREEELYFKFMVKIMEAILANQLLPFAYHAFRESESKDIISPAQAVIMKLLTNIFRARQARAQPTKGLIRPNPPQVDQGDVHMVNFLLTEFRRHIIPQTCALIFLQGQIRAGHAHAEDFPLNLWDMERMYEGVYQYLEFFAILTEHETWKRMLSNWEIANELVTLLKELDAAIPKGNLSVPPLKNTNQPAPPPPQQQQEEEPQFEQGNASVQHPQPQTPQPVAVERPYDTTAAAAEPYIPPPTSPSPRPYMDEAADEPSDFEWRNLKKLAVLVLSSLVWKNKHVQDQIRPLGGIEAVLNCCSYDEHNPYIREHAIMCLRFLMEGNKENQDRIRALEKHTQEKSSQSQSKASSSESVRPVNVRVPDEVLDQQGYETYMDNKGQVMLRKRQPPQTQTPVQKGKAKANFDPAMRDPKALEDLVQQVMRDLPRVQGLGGERASEAEEALKKLDRGFDGGGKG
The following text describes a protein:
Function:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.
Subcellular Localization:
Nucleus.
Sequence:
MGVQGLWTIVQPCARPVKLETLNRKRLAVDASIWIYQFLKAVRDKEGNALRNSHIVGFFRRICKLLYFGIKPVFVFDGGAPVLKRQTIANRKKRREGRREDAVQTASKLLAVQLQRTAEQESAKRRSRRQENEEDVPDNPVYVEETFMTDKQKQQSRTFKKKDAYHLPDMQVSLQEMGAPNDPRIMSQEELEEYARQFHQGEDINLYDFSKIDFDSPFFLSLPATDRYNILNAARLRSRLRMGYSKEQLDTMFPDRMAFSKFQIERVKERNDLTQRLMNINGMNGDEAFYKSGQRIAGERGKEYVLVQDNSVEGGWVLGVVGNKEGGREEKPIDVDRYFHHEITPEPEASEDEGGFEDVPIEGLNRLPKLSFLQPGVFDDSLRQHIQGSQGQDAGADSLFVEDFNNAQHTGDVFDGAAASEDEDLQRAIAMSLQSPNHMDHDAEMPEIPVNRATSLEPQSKPAVEPTIESDDELDFVAAVAQSKRTKAPAKPAPTQTFEGPLPFETLKHRKPLNVKKPEPVENDAGGFEKGPSKEAKENVPLPPWFSGPQQNSEFIADQNDNDLDNYRDRAMTPGHLFLRNHRSPSVIDVDKFPESKVIDLDPAPEADKETAPAQPAELKEIQTPPEPPKPESPDHRASVALEAKVAKDGDVAESVQTDGEESVRSSSPEFEDVTVQPVEAVPAAERERSLEFEDVHLPAEEHVGDGEKTGRLSPEFEDVPIQQVPSALHEVGLAQAVDIDDEGFSDPEDEELMRQLAAEGEEHVRFAATLNSAPHSEGTFDYEQELKQLRSQQKKDRRDADEVTQIMITECQQLLRLFGLPYITAPMEAEAQCAELVSLGLVDGIITDDSDIFLFGGTRVYKNMFNQSKYVECYLTADLEKEYALHRRKLISFAHLLGSDYTEGIPGIGPVTALEILTEFSSLEEFRDWWTQVQTGADMSNSSHAAFYKKFRKQATKIFLPPTFPDARVDAAYLEPEADRDPSPFQWGVPDLHGLRNFLMATIGWSQERTDEVLVPVIRDINQREQEGTQSNITSFFSGPQGAGAFAPRVRSGGQSRMEKAFSRLRREAGADQDAELVDVETDPSSQDLSALPARRKGKGTRKGAKRGAEPEEAAENGQGSRENDGATAKKRRGRKEAKT
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum (By similarity).
Subcellular Localization:
Golgi apparatus.
Sequence:
MTATKEESQKLLTSLRSQRDNKVCFDCGAKNPTWSSTTFGIYLCLDCSAAHRNMGVHISFVRSTVLDSWTYAQLRVMRVGGNENARNYFKRHGGVSLLNSKDCRLKYSSKTAKQYLEKLKSLAVEDEANYPDILDMDFLSNTHEGSSAADTTNEDDDFFSAWDKASVKKSDDNLDDKTDLASTSSSVVVESGEKDEPVVVTEEKTMVSPPSRPDSTSTTKSKTSSISSARARPIRASSRPTASKLGASRPQKLGIKKANADIDFDEFEKAVLSSESAPTKKPAAVASKESTVDTLVDNGVEEVKESTSTTVQGKPVKPVLKSAASAKSTKSDDSNLNANFARLGFGQFAAASNARAKAAAKARELKKNEVNAPTYARDHFASQKSISSDQYFGRGSFDPEAAAEAQERLSSFRDATAISSKSYFGEEEDENEEGESSHRPDSAYLRDIAETATEDIEAIKVAIHQGAEKLSDFIQKVGARYNF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MALGLLRAKTEGAFVSFHDVAVDFTQEEWWLNLVFLRIPFSKPTLVILLEQGAERWREEKEHMLSPCSADPKLEMQAYSSPTLDHCSQQLCQQVFHDHHLPVCPGLFAGNLQIADLCPVYQKEQQLQPLSYGSFWRDRVEGEVREGSSESWFGRTRESITSRPFSSPPEGQLISSCEGKTVVEIGFSSAEKTNSFQKDKLLKCQRSALFIHQRDGSGGKPYFCKCGQAFSQKSNLVTHRMAHSGEKPFTCEECGRSFSQKSTLIRHLRTHLGDKPFGCWECGRGFRDKSNLITHQRTHSWEKPYVCGDCGRLFREKSTLCKHQRLHSEENPHLCNDCGHSFSQKSYLMKHKRTHSGEKPLVCPECGQGFTDKSNLTTHRRTHSGESPYICAECGRGSNVKSALITHQRTHSGEKPYVCQECGQGFRQKSTLVAHQRTHSGEKPFVCRECGPGFRQKSHLISHQRTHSGEKAYVCTECGHGFSQKANLVRHKMGHSREKPFVCRECGRGFSQKAALIRCERTHSREKPVCRECERNFSDKLTLSTHQRAYSGETPSTSSKCGEGFS
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MESRPGRTNLVEPIGHGAALPSGGQAVQPWWTSSGAVLGAVSPAVVAVAPGSGTGISLSSSPAGGSGGGGAAKGAASDESSEDSRRSGEPKDGSASQEKNHATSQIPALAPEYLAPYSQLELNQSIASAAYQYPDPYYAGMVAPYGSHAVAHFQLPGLTQSRMPLPLEVSEEPVYVNAKQYHGILRRRQSRAKAELEKKVVKARKPYLHESRHQHAMRRARGNGGRFLNTKKSDSGAPNGGENAEHLHVPPDLLQLRQNEA
The following text describes a protein:
Function:
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA (By similarity).
Sequence:
MADDEEIDIEGDDDAPLLFDHKDDALALPDLPGYEPNWMFDHGQEIYGRSWTSISQFVQTRTPLQVKNYARHFFKTKVVQKVEEGEDEDVDIEGEESGEEAVMELRSTCGLNPAQPAVVTSDDTSTGENVMEETEAVTEDHPSLDNLVQDDREMPQQETTGDGEQYPMDEHFLPVFPWQPDDTQNRVIVERIEGSVGLGSVRGDKDVRPVPGVEQNTYGPHTDMFQVQNTLLAFEKQVGADRIFEGPSXSKNEATDTQTEVSETKTEVIERQTESQVDATHMHTYGDGLMGSIERLTESVSSSELKEDLKTGIEYVEKDDATDSSSTAKGYDNYTLDHPEDRSKPDSVVSEKWSCEEAMSSHTDGRTFSDSDSGKETYDLPRYNTTIFQGHSEDETSDAGQAEEETFFTFKKPTEEVVLDRSVITEEEKEVHKEFFDGRQTKTPERYLKIRNHLLDCWERTKPEYLRKTVARAGLRNCGDVNCIGRIHGYLERIGAINFGCEEANRGEFPVAKVGVKRNPQGHGEQLALQAARLESMHVTSDELEKQDGGVSQIRPNRSRAARTNLNSFSYDPFKLVPCKRFSEESPAPFSVKIHATALVTIDMHAHISTAEVIGLLGGVFHRDPGALEVASAEPCNSLSTGMQCEMDPVSQTQASEALSQAGYSVVGWYHSHPTFAPNPSVRDIETQTKFQEWFAQGGSPFIGIIVNPYSSTRISPLSRVTCLTISSEWNPPAIQRVKLLSRYAGHTDTTYMDKMLYSLSGHLCRGNADSDEDGNSESLTLLTDIRDIFANSWTSSLGTTPRSSIASL
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MMAAFSMEPMGAEPMSLGSPTSPKPSAGAQFLPGFLLGDIPTPVTPQPRPSLGVMEMRSPLFSGGSPPQPVVPTHKDKSGAPPVRSIYDDIASPGLGSTPLNARKTANFSVLHTPLSGVMPSSPESRNFSGSRKRAASSVFSPATIGQKRKNTLSPAQMDPFYTQGDALTSDDQLDDTWVTVYGFPQASASYILLQFAQYGNIIKHVMSNNGNWMHIQYQSKLQARKALSKDGRIFGESIMIGVKPCIDKSVMEAYEKVTTPSVSSVFTPPVKCIGTPTQSAGTPRAASMRPLAATYKTPASADYQVVTDKPAPRKDESIVSKAMEYMFGW
The following text describes a protein:
Function:
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Sequence:
MSRSLGIPVKLLHEAAGHVVTVELKSGELYRGSMIECEDNWNCQLENITFTAKDEEARQAAFSTGNLQLVGTDHCAFNSTQEAFGMNDFRKIPSALNVLESSTCIQGKEQYLLDLMQT
The following text describes a protein:
Function:
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MATTLIRRAMSMTSRVSSSTVAPALRLVVTRPYASEAEAEKGDAATTNMKTFQIYRWNPDNPSKPQLQDYKIDLKECGPMVLDALIKIKNEIDPSLTFRRSCREGICGSCAMNINGCNGLACLTKIESGSSETTITPLPHMFVIKDLVVDMTNFYNQYKSIEPWLKRKNPPPTAGKEIPQSKKDRAKLDGMYECILCACCSTSCPSYWWNPESYLGPAALLHANRWISDSRDEYTKERLEAINDEFKLYRCHTILNCARACPKGLNPGKQITHIKQLQLLGSA
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLIDSLHVSFDSFNFESILPMLVLVCGGIFTLLINAFTSRFSRNLNVFLCMLFLVLDFLVVLGLEEQENAFFGFLSLDTLSLISQSIVLISAFLLIFLALSKERFNEFQTAEFYSLYLFIVAGFQFMVSSNHLLLILIGLETASLPLCVLMALSDKRYGLEAGIKYFTMGAMASAFFAMGAMAFYLLTGSLNLEVITLYLHTEGITNPMLFAMGAIFLIGAIGFKVSLVPFHTWMPDVYEGNNPVFASYISIVPKIAGFVVATRLFGAFIDTRTAWVEDIFYVLILMTITIPNFIALWQEDVKRMLAYSSISHSGFALACVFIHTEDSQQAMFVYWFMFAFTYIGAFGLLWLLKSREKTWDERYDHPYSKFNGLIKTHPLVAILGAIFVFGLAGIPPFSVFWGKFLAVESALESNHILLAVVMLVNSAVAAFYYFRWLVAMFFNKPLQSYAQNDIYTQNATMPIYAVIIAMALACLFSVFMMRGLLEFVA
The following text describes a protein:
Function:
Sodium-activated K(+) channel. Acts as an important mediator of neuronal membrane excitability (By similarity). Contributes to the delayed outward currents. Regulates neuronal bursting in sensory neurons. Contributes to synaptic development and plasticity (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The cytoplasmic N-terminal domain facilitates the localization of heteromeric KCNT1/KCNT2 channels to the plasma membrane; The cytoplasmic gating ring domain of the closed KCNT1 channel harbors multiple K(+) and Zn(2+) sites, which stabilize the channel in the closed conformation. Under low-Na(+) conditions, the abundant cytoplasmic K(+) ions stabilize the gating ring domain in a closed conformation. The open KCNT1 structure contains at least two Na(+)-sensitive sites in the RCKs domain where Na(+) binding induces expansion and rotation of the gating ring that opens the inner gate.
Sequence:
MARAKLPRSPSEGKAGPGDTPAGSAAPEEPHGLSPLLPTRGGGSVGSDVGQRLHVEDFSLDSSLSQVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDNPDQGIGCWGCTKYNYTFNGSSSEFHWAPILWVERKMALWVIQVIVATISFLETMLLIYLSYKGNIWEQIFHVSFVLEMINTLPFIITVFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGGNLNLLTSFYFCIVTFSTVGFGDVTPKIWPSQLLVVILICVTLVVLPLQFEELVYLWMERQKSGGNYSRHRARTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPSEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREENKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKQKRRGLAGQALYEGPSRLPVHSIIASMGTVAMDLQNTDCRPSQGGSGGGGGKLTLPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRRELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKQERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKVTEDDLWIRTYGRLFQKLCSSSAEIPIGIYRTECHVFSSEPHDLRAQSQISVNMEDCEDTREAKGPWGTRAASGGGSTHGRHGGSADPVEHPLLRRKSLQWARKLSRKSSKQAGKAPMTTDWITQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHHQNTLSYVLINPPPDTRLEPNDIVYLIRSDPLAHVTSSSQSRKSSCSNKLSSCNPETRDETQL
The following text describes a protein:
Function:
Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Also stimulates the expression of the mta gene itself, ydfK and ymfE.
Subcellular Localization:
Cytoplasm.
Domain:
The central dimerization domain of the first subunit forms a two-helix antiparallel coiled coil with the dimerization domain of the second subunit.
Sequence:
MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDADLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTIDRTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSADDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGEVYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP
The following text describes a protein:
Function:
Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
SEAVAEKEDDPNFFKMVEGFFDKGAAIVENKLVEDLKTRGSPEVEGNLTFT
The following text describes a protein:
Function:
Putative oxidoreductase (By similarity). Required for vegetative shoot apex development, especially during leaf positioning and for shoot apical meristem (SAM) maintenance.
Sequence:
MSDETTSSPSPAPAKKKQNLGWMEWMRGWSSVFGEILFQRITASHLENPLPLPSVNDLTCVVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELILQWQNEWSGKGLPLNIEAMEIDLLSLDSVARFAEAFNARLGPLHVLINNAGMFAMGEAQKFSEEGYEQHMQVNHLAPALLSVLLLPSLIRGSPSRIINVNSVMHSVGFVDPDDMNVVSGRRKYSSLIGYSSSKLAQIMFSSILFKKLPLETGVSVVCLSPGVVLTNVARDLSRILQALYAVIPYFIFSPQEGCRSSLFSATDPQIPEYWETLKNDDWPVCPFISQDCRPANPSEEAHNTETAQRVWKKTLELVGLPLDAVEKLIEGENIQCRYGAQHE
The following text describes a protein:
Function:
Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase by activating the expression of genes involved in meiosis and post-meiosis during spermatogenesis. Maintains the repression of pre-pachytene transcriptional programs, including meiotic double-strand breaks (DSB) formation genes in pachytene spermatocytes and suppresses aberrant DSB formation after mid-pachytene, thus ensuring meiosis progression.
Subcellular Localization:
Nucleus.
Sequence:
MEPYSLGEEGALPSEGHLPSFSESQVLNCSDTLNRDLGPSTRDLLYAGLSGLDLDPSLSTSDMPSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQTSLQDLGLGALKVPKEADEGGRATGSTRKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYLTHSQERKHVCKVCSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYEVQHGVCILKETPPEEEAYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPNRDLLRCIVSSIVHQKIPSPGPAVGPSDTEARSSACACPTSLGSSSCTPASTPVALGTLGSEIPEETHPPRKEAATEVFTPVQSRAAENGVPDPPESELESESPRLQRPSSLEGWPEGSSLPACLPLFRGHSVPSGSQPSSHNFQWLRNLPGCPKNKGSNVFMVHKPPAVASREGSEGGGSGPSSTPTSVEPSPSLGTTQEELLPFPPALLKAPGEASSEVRQAAGEDETWAPKKCKPDCESFPWQSPTELGLQDAQNPGGLPSDATPLFRQLFMKSQESLVSHEQMQVLQMIAKSQRIFSHTQVATASAQRPGPEGKQSTLKPLQGPWPPQTLPPAPTVDSFQIGPGHSEPEGSPVRRRKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPGLLPSRNPDSSSLAKGTLDLGDIIPNAGSRQSQLGGDEPAGTQLVGKQGQGENGLASGAMRGEKGPACPRGGGYRLFSGHPRAQRFSGFRKEKVKMDVCCAASPSQVAMASFSSAGPLADPPRDMKSKLTIFNRIQGGNIYRLPHPVKEESLAGGCHQPNGGPTDWMESKSTFVCKNCSQMFYTEKGLSSHMCFHSDQWPSPRGKQEQQVKGQMVASVKRKAGREEGAVEDMKRHYDCSSSEPQDVTILSMLVSSGSCGVTPVVLSSLLQGQEKDGEERDSKESCQYRKRKKRPQPKALFAPPAPSALGEPGPGGCHQSCLHSPVFLVDHLLKGLFQCSPYTPPPMLSPIREGSGLYFNTLCSTSRAGPHLISPVLDQVDSSFGICVVKDDTKISIEPHINVGSRFQAEIPELQERLLARVDENVASLVWKPWGDVMTNPETQDRVMELCNVACSSVMPGGGTNLELALHCLHDAQGSVQVALETLLLRGPQKPRTHPLADYRYTGSDIWTPMEKRLFKKAFCAHKKDFYLIHKMIQTKSVAQCVEYYYIWKKMVKFDCGRAPGLEKRGRRELDEVERTEDKVTCSPRERPTHRPTPELKIKTKSYRRESILHSSPSAAPKRTPEPPGSVESQGVFPCRECERVFDKIKSRNAHMKRHRLQEHVEPVRVKWPVKPYPLKEEEEEEEEELGADMGPLQW
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTSTIAGLPIPDSDLCHVQWRSLAWILEHGPLTESNAIDYFALSPFYDRKSTNQVLRMQSMFSGQPKMDPASEQEALRRFIGIEYALVLSRPEPDREGGLFIIEKRERKGYDEYYPIASYYILKTSIYQAPSLYATLSARVLTSLSALQRLLELARQHKPTYDPRHSYAWKIKEKPEENTVDKQSTDQPTTESTTEVEPTTQESDRMDIDMTAPEKPDGPAKTTLKKKNHDTPELSNPILFRALQNTITNFPAFKPPPAVEAVPE
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MTDPPKSVKETVELDFFPASGKRMTPRKTVVGGEGVASAFNGGQLLHLGNPSSTAPPPHDASSSSISSGVASTGGAGGCTSPMTIFYNGSVSVFQVPADKAMTLMMMAEMAHAKVEVTEIASQSTEMIAPSSSITTTTGFGIQHFHDIADNGDNLVRARRLSLQRFMERRSKKTKINQLLN
The following text describes a protein:
Function:
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Sequence:
MYKTQMEAAKKGILTKEMKSIAESESIDEKVLMERVASGEITIPANKKHSSLLAKGVGTGLSTKINVNLGISKDCPNVDKELEKVKVAIDMKVDAIMDLSSFGKTEEFRKKLITMSTAMVGTVPVYDAIGFYDKELKDIKAEEFLDVVRKHAEDGVDFVTIHAGLNREAVNLFKRNERITNIVSRGGSLMYAWMELNNAENPFYENFDKLLDICEEYDMTISLGDALRPGCLNDATDACQIKELITLGELTKRAWERNVQIIIEGPGHMAIDEIEANVKLEKKLCHNAPFYVLGPLVTDIAPGYDHITSAIGGAIAAAAGVDFLCYVTPAEHLRLPDLDDMKEGIIASRIAAHAADISKKVPKAIDWDNRMAKYRTDIDWEGMFTEAIDEEKARRYRKESTPENEDTCTMCGKMCSMRTMKKMMSGEDVNILK
The following text describes a protein:
Function:
Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.
Subcellular Localization:
Cytoplasm.
Sequence:
MFTNSIISKSTTRLTQLSRQLSTTTMAPTSTKNSIKHFDYLVIGGGSGGVASARRAAKYGAKVLLIESNFKKFGGTCVNVGCVPKKVMWYTADLAHKKHDLYAYGLDKEPDSIKYGDFDWAKLKHKRDAYVTRLNGIYENNLKREKVDYAYGFAKFINSEGEVEVTLSGDQELPFLDEGKTYKKGEKLVFSADKTLIATGGTAIVPPSVPGAELGTTSDGFFALEKQPKKVAIVGAGYIGVELSGVFSSLGSETHFFIRGDTVLRSFDEVIQNTVTDYYIDNLGINIHKQSTITKIEGSKDGKKVVHLKDGTSVEVDELIWTVGRKSLIDIGLDKVDVKINDKQQIVADEYQVTNNPKIFSLGDVVGKVELTPVAIAAGRRLSNRLFGGPEFAKDKLDYNNIPSVIFSHPEAGSIGLSTKEAIEKYGEENLKIYQSKFTAMYYAMMDDQKDKSPTVYKIICAGPEEKVVGLHIVGDSSAEILQGFGVAIKMGATKKDFDNCVAIHPTSAEELVTMT
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CD44. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGIAFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MKKQPKKIFKEKDDTATTEIKKSVVHFEESTKLSYRSDNLIAKEEASIAEYFECLNCKLAVGLIKTLMKAKVPKNVISNIVTSGCVLFNQGSHDVCHGVVSMFKNEVFEVLSNITISPLEVCEVLLTKNCTRKESKYFQWDVDLPVPSHDRTAEKNLPMTKPTPKLKVLQLTDIHIDFLYKPQSAINCNDPLCCRNGQPTEPSNMAGYWASLGACDMPTWTVDDLFNKLSKEKFDYILWTGDSLSHNVWNQTRDDQLKVLHYIAQRFDKYFPNIPVFPALGNHEGVPVNSFPFAKNMEDKENPMSWLYETMKNISSKPNEDKENPMSWLYETMKNISSKWGGYYTMQVIPGFRIVSLNMNFCNNLNGWLLLNPIDPSSEMKWLVDVLQEAEDNNEKVHIIGHIAPGLPECMQVWSRNYYKVINRFHKIISAQFFGHLHYDTFQLFYDLDLYKINTPTSMRTDINLKPISVAYLSPSLTTFININPGYRVFHLDGFHDESTWSVLDHETYIMNITLSNTLNQTIWVKEYSAKEAYQLESLSPLDWHDLILRMEWNATLFNFYFKNYFKSNMGQESCDAKCKMYMLCSLASGKSYDDEFCQHIFKHSTAFSNFRRDFQYSEYTTWYKKLKSC
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Miscellaneous:
MISCELLANEOUS: Present in outer membrane vesicle formulations which are used as vaccines in human.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MEQQQRYISVLDIGTSKVLALIGEVQDDDKINIVGLGQAPSRGLRAGMVTNIDATVQAIRQAVNDAELMADTKITHVTTGIAGNHIRSLNSQGVVKIKDGEVTQADIDRAIETAKAINIPPDQKILDAVVQDYIIDTQLGVREPIGMSGVRLDTRVHIITGASTAVQNVQKCIERCGLKSDQIMLQPLASGQAVLTEDEKDLGVCVIDIGGGTTDIAVYMNGAIRHTSVIPAGGNLITKDLSKSLRTPLDAAEYIKIHYGVASCDTEGLGEMIEVPGVGDRTSRQVSSKVLAAIISARIQEIFGVVLGELQKSGFPKEVLNAGIVLTGGVSMMTGIVEFAEKIFDLPVRTGAPQEMGGLSDRVRTPRFSTAIGLLHAACKLEGNLPQPENGAVQEREGGGGLLARLKRWIENSF
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MDLSDKGWGSEDMMSQAESQLKTCADCGTTKTPLWRGGPAGPKSLCNACGIRSRKKRRALLGLNKEDKKLKKSSENKNQYCSNSSTSSSGDSTSSSSSNGCLLKKKFLPFGRQVVALQRPRSRSRSSSTHKLGEVEQAAFLLMALSCGSVYA
The following text describes a protein:
Function:
Autophagy receptor that interacts with and facilitates the transport of cytosolic hydrolases Ape2, Ape4 and Lap2, and of mannosidase Ams1 into vacuoles. This Nbr1-mediated vacuolar targeting (NVT) pathway depends on the endosomal sorting complexes required for transport (ESCRTs). NVT components colocalize with ESCRTs at multivesicular bodies (MVBs) and rely on ubiquitination for their transport.
Subcellular Localization:
Golgi apparatus. Endosome, multivesicular body. Vacuole lumen.
Sequence:
MLCNRTCPSSDCGILCNHSVPSFPPFHSSVANIHFTKENNLKSNIFEHNNNSPTLRSSSVACNTCLKIIRNDSFHCTKCFDFDVCRDCYAKQAFLHPCPKPHFVLVRSSIPSVASLTCSVNSMSVSPQSNFMYAICDHCEQPIHNVRYKCSVCDDYDICESCLTDNSHSNTHAFVRITKAYPHGLPSFHLFPQFLSAELFESASTVHRSVQCDNCLAHPIVGPRFHCLVCEDYDLCSSCVSHVHHDHHSMLRLTREISASPLHLSKPEKPKVLNFDFKLVEDSILPLELSPGCPFYKIWHIRNTSCQSWPSPLYVKFNGGDKLFPGDNPYSFPITSSVHPGEDVNFTVALKVPEKSNKEIFTAFFNICSDDGSVFHKSLCAFLRVPKSFSRISKSSF