lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MLSSTARRLVRDPVPTDTKAFYTWFSGQAYRQERVIPGGYPAVRVYPVYGKRWFTGRTVIAIVAGISIFGAWVRPERERYNMEMMIEFAERQAAHLPYQTAEVNLRCFITGYKRYRYEKENLIDKGYVGLTSEFRKFFYHNDVWRPPLHDVLMHPYVKYGGPMGSYNWSVGYF
The following text describes a protein:
Function:
Probable histone methyltransferase required for embryonic development.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MNYEEITTTIPGPGVSQDDWNDEFQGCDCETQCSIENQCSCMTGATDNYSEDGRIVATSLLIECSTNCACCLLPYSCRNKVVQNGIKKKLKIFSTSEKGDGVLAEEPIQNREFVCEYAGECIGDQEVKRRCEVFKEEDNYTLTLKEHFGEKEVKTFIDPRLRGNIGRFLNHSCDPNCEIFVVRLGRMIPIAAIFAKREISVGEELSYDYGVSGIDGDNRKLCLCRSENCRKYLPMSVSPIE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.
Miscellaneous:
MISCELLANEOUS: AMP nucleosidase binds AMP at the catalytic site, Mg-ATP at an allosteric regulatory site, and inorganic phosphate also at a regulatory site.
Domain:
Each monomer consists of two domains: a C-terminal catalytic domain and a putative N-terminal regulatory domain.
Sequence:
MNNKGSGLTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVIDGSELTLDRSMSAGLTRYFPTTELAQIGDETADGIYHPTEFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKLPGQANRFYEGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR
The following text describes a protein:
Function:
A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSKSQRDHLMHSTGTTPYEIIGVILPSLFYTTITTIIVTLLQTRPKNLPLQFTIEFLTLVLPIILNVTVLSDYTFELLSTFLIITLSLILWLRGSKPLSAKPPQAPLTHDYITNSRSTINIISVIAILAVDFLIFPRRFAKTKTYGYSLMDVGVGLFIFSNGIVDAGRTDLGRSLKGAVPLLVLGVGRFFGTKLLGYHVPVTEYGVHWNFFISLAVIKIVVSLVFSVIEVKYIFINATLLLLSHESLLQGGLKNFVMDDHKRSNFLTANREGIISCFGYVSLYMFSANFSYFVGLKKGGEGVKKTVIKFVFLATLMLFLSQIWQKYCGISRKLANSAYCFWVLFIGIFMTGLYYIFAKILEDTFRNKLHVNLQLPLIFQAINYNGLVFFLVSNLLTGLVNVLCDTLQVSSVVSLGIITVYMLVNCAIVCVLFTKQIKLKL
The following text describes a protein:
Function:
Transcriptional activator that governs the viral transcription from the 5'LTR via the recruitment of dimers of host phosphorylated CREB1. Together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription. Increases host CREB1 O-GlcNAcylation to further increase 5'LTR transactivation. Also modulates the expression of cellular genes leading to the deregulation of T-cell proliferation, perturbing the integrity of cell cycle checkpoints, the DNA damage response and apopototic pathways. Acts as an ubiquitin E3 ligase and stimulates host IKK complex by catalyzing the assembly of free mixed-linkage polyubiquitin chains, resulting in constitutive activation of the transcription factor NF-kappa-B. Inhibits the host nonsense-mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs by interacting with host UPF1.
Miscellaneous:
MISCELLANEOUS: HTLV-1 lineages are divided in four clades, A (Cosmopolitan), B (Central African group), C (Melanesian group) and D (New Central African group).
Subcellular Localization:
Host nucleus. Host cytoplasm. Note=Shuttles from the host nucleus to the cytoplasm. Found predominantly in the nucleus, where it is equally distributed between the nucleoplasm and the nuclear matrix.
Domain:
The 48 N-terminal residues contain a non-canonical functional nuclear localization signal (NLS); The PDZ-binding domain mediates binding to human DLG1 and MAGI3. Interaction with other PDZ domain-containing protein induces IL2-independent growth (By similarity).
Sequence:
MAHFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQFLIPRLPSFPTQRTSKTLKVLTPPITHTTPNIPPSFLQAMRKYSPFRNGYMEPTLGQHLPTLSFPDPGLRPQNLYTLWGGSVVCMYLYQLSPPITWPLLPHVIFCHPGQLGAFLTNVPYKRIEKLLYKISLTTGALIILPEDCLPTTLFQPARAPVTLTAWQNGLLPFHSTLTTPGLIWTFTDGTPMISGPCPKDGQPSLVLQSSSFIFHKFQTKAYHPSFLLSHGLIQYSSFHNLHLLFEEYTNIPISLLFNEKEADDNDHEPQISPGGLEPLSEKHFRETEV
The following text describes a protein:
Function:
Required for normal beta-1,6-glucan synthesis, for hyphal morphogenesis, adhesion and virulence.
Miscellaneous:
MISCELLANEOUS: Present with 3460 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRLFVLLAYIIPFILCQLTPVLVASHKLVRGLKEEINPSNTLPHNVTSVTNMLKKLITECSSDAYLLINQPGLTYADLTTEKKDNWPFLRNYLYMSSTIVGLPRVENPIDLDFLEQYIISNCDAETINVWHDSEDEVVDYYDIRKRVIRIDLSPLSISNHDDRVKEIFEHDQLIRKILRKLPSAHYTIILTSLEPGIIHPVPRFLMEETPASFEIFDDIINDPFHNREIEKNDRFHKVEPNWNPIRDSNDRYYRNKKKDEIHLFDYELWEKNEKLITTIFVMVLSLFMMKIISFFNYLKQKIIQKKQQKSKRGIIADDKKLD
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MFRNLAPLAVRMTSSGYSKPVSSFRQYTTLNPISPATPTVEAAFAHNGALGGLPEEHPQVRIARIFKHDREVQGWTNGKTEPSRIVDESHHGALGGYAEEYPPSAHIARIYQQQGWNRTAWKIDLANEKSWENNLLGPSYGDTLLCNVSMHMKFKTKEDAIAFCEENNWTFEVEMLNKP
The following text describes a protein:
Function:
Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. DIS3 has both 3'-5' exonuclease and endonuclease activities. The exonuclease activity of DIS3 is down-regulated upon association with Exo-9 possibly involving a conformational change in the catalytic domain and threading of the RNA substrate through the complex central channel. Structured substrates can be degraded if they have a 3' single-stranded extension sufficiently long (such as 35 nt poly(A)) to span the proposed complex inner RNA-binding path and to reach the exonuclease site provided by dis3 (By similarity). Implicated in mitotic control. Essential for cell division and spore germination. May be involved in regulating protein dephosphorylation during mitosis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Abundant in the nucleus.
Sequence:
MSTVSGLKRPQSSEKNHRDRVFVRATRGKVQKVVREQYLRNDIPCQSRACPLCRSKLPKDSRGNVLEPILSEKPMFLEKFGHHYLIPDSNIFYHCIDALEHPNNFFDVIILQTVFSEISSKSIPLYNRMKRLCQEKTKRFTPFSNEFFVDTFVERLDDESANDRNDRAIRNAASWFASHLASLGIKIVLLTDDRENARLAAEQGIQVSTLKDYVQYLPDSEILLDMVSAIADAIASKEQVESGTKNVYELHWSMSRLLACIKNGEVHKGLINISTYNYLEGSVVVPGYNKPVLVSGRENLNRAVQGDIVCIQILPQDQWKTEAEEIADDDEDVVVSTAAEPDSARINDLELITKRNAHPTAKVVGILKRNWRPYVGHVDNATIAQSKGGSQQTVLLTPMDRRVPKIRFRTRQAPRLVGRRIVVAIDLWDASSRYPEGHFVRDLGEMETKEAETEALLLEYDVQHRPFPKAVLDCLPEEGHNWKVPADKTHPLWKNRKDFRDKLICSIDPPGCQDIDDALHACVLPNGNYEVGVHIADVTHFVKPNTSMDSEAASRGTTVYLVDKRIDMLPMLLGTDLCSLRPYVERFAFSCIWEMDENANIIKVHFTKSVIASKEAFSYADAQARIDDQKMQDPLTQGMRVLLKLSKILKQKRMDEGALNLASPEVRIQTDNETSDPMDVEIKQLLETNSLVEEFMLLANISVAQKIYDAFPQTAVLRRHAAPPLTNFDSLQDILRVCKGMHLKCDTSKSLAKSLDECVDPKEPYFNTLLRILTTRCMLSAEYFCSGTFAPPDFRHYGLASPIYTHFTSPIRRYADVLAHRQLAAAIDYETINPSLSDKSRLIEICNGINYRHRMAQMAGRASIEYYVGQALKGGVAEEDAYVIKVFKNGFVVFIARFGLEGIVYTKSLSSVLEPNVEYVEDEYKLNIEIRDQPKPQTVQIQMFQQVRVRVTTVRDEHSGKQKVQITLVY
The following text describes a protein:
Function:
Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length.
Miscellaneous:
MISCELLANEOUS: Present with 1720 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSGSRGNSSNSSVSNNSNNNNNNDGGDERLLFLRSVGERNEIGFPSRFKSAHYKKPTRRHKSARQLISDENKRINALLTKANKAAESSTAARRLVPKATYFSVEAPPSIRPAKKYCDVTGLKGFYKSPTNNIRYHNAEIYQLIVKPMAPGVDQEYLKLRGANFVLK
The following text describes a protein:
Function:
Part of the ABC transporter DppABCDF involved in dipeptide transport. Responsible for the translocation of the substrate across the membrane (Probable); When a foreign outer membrane heme receptor is expressed in E.coli, DppABCDF can also transport heme and its precursor, 5-aminolevulinic acid (ALA), from the periplasm into the cytoplasm.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGISMKSRIPVWEEFVPRFQATLELGVCAMIFATAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVSGRVSDMVFLDDSNPLTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTARAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILVNLLVDLLYGVVNPRIRHKK
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport.
Subcellular Localization:
Cytoplasm.
Domain:
The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Sequence:
MGFLDFFKKTATLDLIAPISGKVMSIDKVPDEAFAEKIVGDGIAILPTSNELLAPCDGKIGKIFKTNHAFSLETKEGVEIFVHFGINTLNLNGKGFTRVAEEGINVKQGEVIIRLDLEYLKEHSESVITPVVIANSDEVSSIEYSFGRLENDSEYILSSSTVLTEEIRHKISQTKPVIAGKDLVLRVKK
The following text describes a protein:
Function:
Promotes matrix assembly.
Subcellular Localization:
Secreted.
Sequence:
MSCVLTGVVPLGLVLLLCGAQGFFLPNVTQLEKLLSKYQGDQPHSRTRRAISRADREEILTLHNKLRGQVSPPASNMEYMTWDEELEKSAVAWARECIWEHGPTSLLVSIGQNLAVHWGRPRSPGSHVQSWYDEVKDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNRIGCAVNTCPRMNVWGDVWENAVYLVCNYFPKGNWIGEAPYKTGQPCSECPGKYRGGCKNNLCYQETYGQETETDDMNEVEAAPIPDEKHVWVTPRVIKPKKPKKDSPVNYMTQVVKCDTKMKDKCKGSTCNRYQCPAGCLHSGAKIFGTLFYESASSICRAAIHYGILDDRGGLVDVTRNGKVPFFVKSERNGVQSLSKYKASSSFTVSKVKVQDLDCYTTVAQLCPYEKPGTHCPRVRCPAHCKDEPSYWAPVFGSNIYADTSSICKTAVHAGVIRNESGGYVDVMPVDKKKTYVASLRNGVQSESLRTPRDGKAFRIFAVRQ
The following text describes a protein:
Function:
Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import. Probably responsible for energy coupling to the transport system. Required for full urease activity and plays a significant role in the virulence of S.aureus during urinary tract infection (UTI).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSLIDIQNLTIKNTSEKSLIKGIDLKIFSQQINALIGESGAGKSLIAKALLEYLPFDLSCTYDSYQFDGENVSRLSQYYGHTIGYISQNYAESFNDHTKLGKQLTAIYRKHYKGSKEEALSKVDKALSWVNLQSKDILNKYSFQLSGGQLERVYIASVLMLEPKLIIADEPVASLDALNGNQVMDLLQHIVLEHGQTLFIITHNLSHVLKYCQYIYVLKEGQIIERGNINHFKYEHLHPYTERLIKYRTQLKRDYYD
The following text describes a protein:
Function:
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEFVVSSRVPFLYLLFIFLHVSSAVDANISIIVPKGRSLPLFNGSLIEEHKKQIQSSSVELVVPLICLFSFTAGLPTNSFALWVLLFRTKKLPSTILLINLTICDIMLLLVLPFRIVYHFVGNNWTFGEPFCRVVVGFFYGNMYGSVVCLALIALDRYIALVHPFGAKVLRSKKNSVYMSVLVWIVVLAAAVPLLASKQTHEINNLSITTCHDALPVEEQENYFLPYFTTLFSLCFLLPLLVVLFCYSAVLRTLMAEGQRFAHAVRVTVLMLIVFVVFLLPSNILMLWHYSKSSSVNNLYMPYLIALSLSTFNSCIDPFIFYYVSKDFRKRSWEALRCLKSDLESSSDSRTKVTLLSKISKTERPLNGESTHL
The following text describes a protein:
Function:
High-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTSAWISRLLLHRNEYLASFSATLCIFMVLCTNAWSSPALPKLLNVPNPPLSITSGDGSWIVSIQAIGGIFGMILAGLTVDRFGRKWPFIASALPVIAGWIMIALARTALLLYIARFLFGISYGVAYGIVPIYIGEITSDGVRGAAASLITVLAKVGILFEYSVGPYVSFETLAWLSMVGPVLFLLTFVWMPESPHYLLGRGRIAEARRSLQWLRRTIDVEEELNCTRKSIERTTSERGSMRELFLPAYRNNLIIVLILALGMQMSGIQAVLSYAQTIFSQISSDLTDAQMSIVLGVVQMVTVSFPVFLVDRVGRRPLLLWSGVGSCIGLLLVSIYFTLEAAGVNVESFGWVSFVGLLFFVISYAFGMATVPFAIMSEIFPKNIRAHANALFGILSGVTIFAVLKLFQIALDNVGAYLPFWVFTVSIGLTFGFVFLYIPETKGKSLDEVQEIIAGWRRKRDPSKAVYVD
The following text describes a protein:
Function:
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Postsynaptic density. Endosome membrane. Cell projection, axon. Cell projection, dendrite. Early endosome.
Sequence:
MKRSLQALYCQLLSFLLTLALTEALVFAAQEPSPRESLQVSPSGTIPGTMVTASLSSTRHSSMVATPASVVTPTPHPDGPSSQATAPMATTTPHLDGHPPTNTISTIMATASTPHSEGSLSTGPLPAAMATTSSHSEGRAPGETAPTILLTKPGEATSRPPTAPSRATIRRPPRPPGSSRKGAGSSPRPIPAAPSGHAGRKDGQRGRNQSSTHLGQKRPLGKIFQIYKGNFTGSVEPDPSTFTPRNPLWGYSSSPQPQTVAATSAPSRTSWVPPTTPLVPVEDKPSLSRADQGGGSTFTSQGGEPDATAASGTPASQQRAPVPSQRPHGDPQDGSSHSDSWLTVTPGTSRPPSTNSGVFAATTGPIQAAFDASVSVPSEGLPQGTSLAPQAPAHPTWASESTVSQAEEKAVATPTPTMMGRVPSPLSTVVSTATGNFLNRLVPAGTWKPGTAGNISHVAEGDKPQQRATICLSKMDIAWVILAISVPISSCSVLLTVCCLRRKKKPANPENSLSYWNNAITMDYFSKHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MARRSFCCSITTVVVLVAAFLPLLCGAQTFPAPAPGLAYGFYNTSCPSAESTVQQMMQSILTSNISEAAGIIRLFFHDCFVQGCDGSLLINATNGELFSIPNLTIRRSAIAIVEQIKARLESACPNTVSCSDILVLAARESVTQAGGPSFPVPTGRRDGTTFATNQTVLSFIPAPSFNFSQLNSSFQTKGLNEADLTALSGAHTIGIAHCSAFIGNLYPNVSSRFNSSFAQTLLQSCPSNTSNNVVNMDLVTPNAFDSQYFSNVLSGSVDFDSDAALLNSTTTQSSVQAFAANQTQFFNQFAVSFIKMSMIEVLTNSSGNIRNVCSVFNSNSSSTISLNSSPENFVEQV
The following text describes a protein:
Function:
The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Subcellular Localization:
Mitochondrion.
Sequence:
MAASSSVARAVRQLAFVAARRPAPFVSQRWQLQAQKQRLFSVSAALKEKKYTEDHEWIELSADGKTCTLGISEYAAKALGDVVYIELPQTDMEVSEGDAIGAVESVKSASDILTPISGTVAEVNSELEKTPANVNKDPEGDAWIAKITVSGEPSGKMMSKEEYTAFTEDA
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Appears to be involved in cargo sorting and release of the ESCRT-I complex from the MVBs.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endosome. Late endosome membrane; Peripheral membrane protein.
Sequence:
MNNNVEELLRRIPLYNKYGKDFPQETVTRFQMPEFKLPALQPTRDLLCPWYEECDNITKVCQLHDSSNKKFDQWYKEQYLSKKPPGIVGNTLLSPSRKDNS
The following text describes a protein:
Function:
May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor.
Subcellular Localization:
Lysosome membrane.
Sequence:
MSSILKSSTGSNHSSTSNHSSINNISQLSGSHGVEQQQLRPVLTLDASTAKLMYQTSQEMSSYIQQVANEPTIGLFHVQDHIRRNIPKNVELKKNIKALGEKIEEKSFDIDYSTKTIKTFSEIQTFSNISSLLQQSIERANKLVNNKSLLFVNSQMAAPSSSKTFSSFQQQHKIYQQQQTNLTPSKPTLSNDKTNDNNNNNNNLNFVEKIEKEEKIEKEDEGKEKDEKEKDDKDLNEKIN
The following text describes a protein:
Function:
Increases urine flow and decreases blood pressure when administered to rats by intravenous injection. Inhibits thrombin-induced platelet aggregation. Stimulates cGMP production via the natriuretic peptide receptor-A (NPR1).
Subcellular Localization:
Secreted.
Sequence:
GENEPPKKKAPDGCFGHKIDRIGSHSGLGCNKFKPGH
The following text describes a protein:
Function:
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
Sequence:
MSSMKSVSALDNVVVKSPNDRRLYRVIELENGLCALLIHDPDIYPEGSVPDQIDEDDEDGEEEDSDGSSEDDDDDEDDEEDGEGDEEDEDEDEDEVKGKGDHQTKKAAAAMCVSMGSFLDPPEAQGLAHFLEHMLFMGSTEFPDENEYDSYLSKHGGSSNAYTEMEHTCYHFEVKREFLQGALKRFSQFFVAPLMKTEAMEREVLAVDSEFNQALQNDACRLQQLQCYTSAKGHPFNRFAWGNKKSLSGAMENGVDLRECIVKLYKEYYHGGLMKLVVIGGESLDMLESWVVELFGDVKNGSKIRPTLEAEGPIWKGGKLYRLEAVKDVHILDLTWTLPPLRSAYVKKPEDYLAHLLGHEGRGSLHSFLKAKGWATSLSAGVGDDGINRSSLAYVFGMSIHLTDSGLEKIYDIIGYIYQYLKLLRDVSPQEWIFKELQDIGNMDFRFAEEQPADDYAAELSENMLAYPVEHVIYGDYVYQTWDPKLIEDLMGFFTPQNMRIDVVSKSIKSEEFQQEPWFGSSYIEEDVPLSLMESWSNPSEVDNSLHLPSKNQFIPCDFSIRAINSDVDPKSQSPPRCIIDEPFMKFWYKLDETFKVPRANTYFRINLKGAYASVKNCLLTELYINLLKDELNEIIYQASIAKLETSLSMYGDKLELKVYGFNEKIPALLSKILAIAKSFMPNLERFKVIKENMERGFRNTNMKPLNHSTYLRLQLLCKRIYDSDEKLSVLNDLSLDDLNSFIPELRSQIFIEALCHGNLSEDEAVNISNIFKDSLTVEPLPSKCRHGEQITCFPMGAKLVRDVNVKNKSETNSVVELYYQIEPEEAQSTRTKAVLDLFHEIIEEPLFNQLRTKEQLGYVVECGPRLTYRVHGFCFCVQSSKYGPVHLLGRVDNFIKDIEGLLEQLDDESYEDYRSGMIARLLEKDPSLLSETNDLWSQIVDKRYMFDFSHKEAEELRSIQKKDVISWYKTYFRESSPKCRRLAVRVWGCDTNMKETQTDQKAVQVIADAVAFKSTSKFYPSLC
The following text describes a protein:
Function:
Plays a general regulatory role in the cyclic AMP-dependent protein kinase-stimulated (PKA) signal transduction pathway by regulating the expression of genes important in growth and development. May inhibit the switch from unicellular to filamentous growth.
Miscellaneous:
MISCELLANEOUS: Present with 314 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPIGNPINTNDIKSNRMRQESNMSAVSNSESTIGQSTQQQQQQQQYLGQSVQPLMPVSYQYVVPEQWPYPQYYQQPQSQSQQQLQSQPQMYQVQESFQSSGSDSNASNPPSTSVGVPSNATATALPNGSAITTKKSNNSTNISNNVPYYYYFPQMQAQQSMAYSYPQAYYYYPANGDGTTNGATPSVTSNQVQNPNLEKTYSTFEQQQQHQQQQQLQAQTYPAQPPKIGNAFSKFSKSGPPSDSSSGSMSPNSNRTSRNSNSISSLAQQPPMSNYPQPSTYQYPGFHKTSSIPNSHSPIPPRSLTTPTQGPTSQNGPLSYNLPQVGLLPPQQQQQVSPLYDGNSITPPVKPSTDQETYLTANRHGVSDQQYDSMAKTMNSFQTTTIRHPMPLIATTNATGSNTSGTSASIIRPRVTTTMWEDEKTLCYQVEANGISVVRRADNDMVNGTKLLNVTKMTRGRRDGILKAEKIRHVVKIGSMHLKGVWIPFERALAIAQREKIADYLYPLFIRDIQSVLKQNNPSNDSSSSSSSTGIKSISPRTYYQPINNYQNPNGPSNISAAQLTYSSMNLNNKIIPNNSIPAVSTIAAGEKPLKKCTMPNSNQLEGHTITNLQTLSATMPMKQQLMGNIASPLSYPRNATMNSASTLGITPADSKPLTPSPTTTNTNQSSESNVGSIHTGITLPRVESESASHSKWSKEADSGNTVPDNQTLKEPRSSQLPISALTSTDTDKIKTSTSDEATQPNEPSEAEPVKESESSKSQVDGAGDVSNEEIAADDTKKQEK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1.
Sequence:
QCHPMNEHDTSTTEVRDFDLMDLLRFIIGGGEENDFEAFETEKLAPPASKIVVENLKQRTVTELDPSEKCPVCLVPYSGTVIEMPCNHSFHKDCLHPWLNKTNSCPVCRFELLTDDPKYEEYKKEKEREKEREYRVEQLHNSMFG
The following text describes a protein:
Function:
Probably cooperates with other heat shock proteins in the translocation of polypeptides through membranes. It may counteract the altering effect of heat shock on the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Present with 7800 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNDTLSSFLNRNEALGLNPPHGLDMHITKRGSDWLWAVFAVFGFILLCYVVMFFIAENKGSRLTRYALAPAFLITFFEFFAFFTYASDLGWTGVQAEFNHVKVSKSITGEVPGIRQIFYSKYIAWFLSWPCLLFLIELAASTTGENDDISALDMVHSLLIQIVGTLFWVVSLLVGSLIKSTYKWGYYTIGAVAMLVTQGVICQRQFFNLKTRGFNALMLCTCMVIVWLYFICWGLSDGGNRIQPDGEAIFYGVLDLCVFAIYPCYLLIAVSRDGKLPRLSLTGGFSHHHATDDVEDAAPETKEAVPESPRASGETAIHEPEPEAEQAVEDTA
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MPSASNHGTPRMVGGLINTPLARHINAKKVVNPVIQSFKVAHQRVNIDIDLSSNSIDGFTELTVIPTSNKLKVIKLDCREMEIKDVLINGSRSLNYVYDDLLYINNPEYFEHCIDSKVINVMDLYSDTFNVHQHHLIRSKLDYIFKNPKHDEESLDYNTQELKILLPDNMKFELTDINSIQTPSGTSHPGTTTPSHLKSKGTGNEYYYTPIQLKVVYKVKNPQNGVNFVTNEDIEKKLWHAYTTNSNYNVSTSSWVPCIDDLSSRCTWSLEVNIPRTLKDIGNPRMIGSKEALDYQQMRRKRSGEAIQNFAQQNNDSDDDDDDDEDIGNYDMVVPSGDFNNVKETPHPIDLSKKVVSWSIFNPVCAHHVGWAVGCFESFVLSDESAGAKEDDEEDTVLRGDDAENVNNPVTIYSLPEDVEWAKNTSIITNKALDFFSKEYGSFPFSSYAIVFVRYSPCQTSNFAGLSVMSSKLLYPPDMIEPMFTVTDILLKSIATQWAGINISPQTFNDMWCTIGIAGFMAISFIKKLMGANEFRYRLRKQMDKVVAEDVGRHAIASQPFKYPVSEDDLSFVWLKSPIVLFILDNRMTKTDKSFGLSRVLPKLFLQAMSGSLPNGTLNTEHFRYVCEKVNRNKLENFFKQWVFGAGAPVFRISQRFNKKKGMIEMNIRQVQHHERTPKKLDSSSFIGDAVAYLDNEPLPPQQHVFTGPMTIRVHESDGSPYEHIVELKEANTKLDIQYNSKFRKIKKKDDGVDPGIAFNQFGDVLLSHAEMQEWNLRDWDKRDEESLSSEPFEWIRGDVDFEWIARIDIKQPDFMFGSQLVYDRDIEAQLEAVRYFGELEKTNTTYCTALTRTLMDDRYFYGVRIAAAQALADCSNEANNFIGLEYLLKAFGKLYCFDDSFIPKSNDFSDFRSFMLQSAFPRILCGVKDNDGKVPKRIQNLLLNLVKFNDNSMNAFVDSLYVSELVVSLVTSTVSGWRNDIEEYNDTEFAGKVSSELFRLQKLDRWIPSYQNIIEVTCIQQNIRMALVGARKLSFEELLYMTLDKYPMEARVEAFRGILELGGLKNKSILQYFLKVCLLNFERPLYRSKLIEALVKSVSSVATYGGVSTLDDPEFHTKVDTNVKSSSNRIIIDDGSQDNLAMKSKRDDMARASIKGAIEILRRDFSEGQGLRETLWELLHTSLIGLHERRSIFCLCQVLFKGVDSYVVKLPVPSMPVEEYVRKKIVAKVSNYPGQVTIKREGRFKIQLATRKSVIAKVKSETEHKPLKISLKPVIEAKQKAASAVHVDPVIPTKVTFKLPGHRLAGFAKKVELDGTLVTIKLGRDMKSKVDALAHRYVRINTKRRKIEVSKVPFIEKEEGSNTSGITEVSRNTGEKEDAKSPSPILVKKEKKRPKVYIHFGGNVKKPDQGSSSSSSKEGSTEVE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MEDILDNIEIKNSLQKQINEVMDENEKQYNEIKAYIENEKKQIEIMKNKTKEKKISINRLNHEIEANTVLVTELKESVMEEEKKLEEYPKLISEINNKLNLILKNFDSSKLEYNTVKLHKDYIQGEWKKKLETLYKLLGFEIILEDDKIVIEFSNIQDSEPQKKYRATLVLKNGIYEVIETNPRINKFEDFVDSLNKGLPFTTFCCLLRRSFKELK
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MTNVYSLDGILVFGLLFVCTCAYFKKVPRLKTWLLSEKKGVWGVFYKAAVIGTRLHAAVAIACVVMAFYVLFIK