lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MKRNNNLIIPLLKIKKLLKRKGCKRIQNSALVFFSKVLQYLIEELLEISMNVSILNKTKKYRIKPKDISWSIQSDPEFNLLFRNIIIPSSGRISNKLNRIIQRSFKFKSFKFDDYEKSDYSSKTF
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength.
Sequence:
MGLQGDKVSLPQVFSYSEAITVMFSSESGRGTRQGHLHMQGPLKARKLRLNRDPVPASPAEAPPLPPRGPALSVGPASAASPSAPRLPRLPRTLKMAAAVGRLLRASVARRVSAIPWGIAASAALRPAASQRTCLTNVLWSGFNQAKLAFSTSSSYHTPAVTQHAPYFKGTAVVKGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIPLLSDLTKQISRDYGVLLEGAGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVEAHGEVCPANWTPDSPTIKPHPTASKEYFEKVN
The following text describes a protein:
Function:
Probably involved in resistance to biotic and abiotic stresses. Confers tolerance to oxidative stress and mediates pathogenesis-related (PR) genes expression. Exhibits RNA-dependent ATPase and ATP-dependent RNA helicase activities in vitro.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MEVAGAQAGILPLLLRHPASLRGSLSLSCGGARRSWAAAAATAEGGGGEEGRGYERVPMDTPGAYRLVDRATGRSVIVWGGTDDVSMPSPAVLSTTTRVPDRPKENGRSTSIGNFGRLKAQKVKVLARRSAHLKREDSGRISTSRFSESPSDESDEDGTYFERDRARNTRQNSRSRDDKTRGAHSLNSVLRQYRGADDLDFPGSEATSGSKRWGNISDVTFGRQNQRQKGPLDSGFFSRRSFKEIGCSDEILGALRSFGFPRPSHIQAMAYRPVLEGKSCIIGDQSGSGKTLAYLCPVVQNLRKEEVEGLHRSSPRNPRVVVLTPTAELASQVLNNCRSISKSGVPFRSMVATGGFRQKTQLESLDQELDVLIATPGRFLYLLQEGFVQLNNLRCVVLDEVDILYGEESFEQVLHQLITVAPLTTQYLFVTATLPLDIYNKVVETFPDCELIMGPGVHRTSSRLEEILVDCSGDDNEEKNPETAFSNKKSALVKIIEESPVRKTIIFCNKIETCRKVENALRRVDRKASQIKVLPFHAALDQQQRIANIKEFLNKQTADSMFLVCTDRASRGIDFANVNHVVLFDYPRDPSEYVRRVGRTARGASGNGKAFVFAVGKQVSLARRVMERNIKGHPLHDVPCV
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Sequence:
MDFESLFTQICHDLEKSGHVKEISTRFSTCSTDAQRISFVLALDSVRARFQEPLSLAKRAISTPCKSQELSTSHRVEGNNYYQKKLNWKAISSYNRSLLVGEGEALALAYANRSAVFHDTSDWLHSLRDIQLAFDHGYPKHLEYKLRERQGNCWLQLGHVRQAFISFNLARNLLLVTTTNAQQSHKDKLISINSKIVKLGDDANPTIGVSESNESAAASIERQVIKKRRTAPDLNRDSNALLPAASTSIELTDSDDRGRCLVATEDIQIGTTVIVEKALASILLEEFKESHCHHCLHWTPGPVPCHQCSQVGFCSTLCRDEAWASYHQSECGLTDSLHGTNVGRHGLLAVRTVLKVGRQRIMDVASEDDGCNPAGGELYDSTDYGRTIHRLVGNTARRSVADLFRRAVMAVYLTSLIQQQRDGKEDDPDEILATAVLQLIQSYPCNAHEISHLAFPLPGTPSGPDLPSTLQQIRLCEIGAAAMPVLSLINHSCDPNVVRDCYGDVIAVKAIRRIARGDEILDNYGYHYATHDKKERQLKLSQQYYFRCNCLACAQDWPRYEDAPKLVDRPELYHPIHRDIGNFSSLSSGSCYPDGPAHLEESTRLFIGYLEAMDSDASIHLPVQEYSMAQEVLKHCWALSATLSPHLAVVV
The following text describes a protein:
Function:
Transcription factor, which is required in the single sleep-active ring interneuron RIS for sleep-like behavioral quiescence induced by neuropeptide signaling in larvae. Regulates gene expression of sleep-inducing FMRFamide-like neuropeptide flp-11 in RIS.
Subcellular Localization:
Nucleus.
Sequence:
MFNRKLMECSDDEFVRGSQCDEEDEEEQQRQSSQRPPFYENMRTFAPSHMHISCHYDIPYPPHLIQPPVCGVSTFTYAREFPVSNSQQFFNVTPPQQQQQQGTGGSGEEDYCIPKSEDRDHSSNYSQVATKQDRPFVFFASDCQSPLEIVGEVYCTVPGRTSLLSSTTKYRVTVAEIQRRISPPECLNASLLGGILRKAKSKDGGKTLRDSLKKLGLTLPAGRRKQANVTAWTALVEEEAIHMAKEFALVCEKEFHSREIGIYLTKTSLAIDPDVVKRRTALEMSRKVVGELAELLSCDRTPLTPYFPRNMLPIDPSVQQHLSHFTLMTHGFGNVAMSAVLESVKLMIDESIKYIDRCCSQNVWR
The following text describes a protein:
Function:
Essential component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. Plays an essential role in the outer membrane localization and assembly of PilQ into secretins which are dodecamers of PilQ.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Domain:
Contains six tetratricopeptide (TPR) protein-protein interaction motifs. TPR1-TPR4 form the minimal region required for secretin assembly and function.
Sequence:
MTVRAALVFLLAVGLTGCVTSGDQNPLKTDKGRDEARDAYIQLGLGYLQRGNTEQAKVPLRKALEIDPSSADAHAALAVVFQTEMEPKLADEEYRKALASDSRNARVLNNYGGFLYEQKRYEEAYQRLLEASQDTLYPERSRVFENLGLVSLQMKKPAQAKEYFEKSLRLNRNQPSVALEMADLLYKEREYVPARQYYDLFAQGGGQNARSLLLGIRLAKVFEDRDTAASYGLQLKRLYPGSLEYQEFQAEK
The following text describes a protein:
Function:
Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MERSPGASLVERASAPSDPPARPPGAHTQRDRTSGNQPAGPGAAAEALALLTSFGRRLLVLVPVYLAGAVGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERLTAQTLYLSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRIVGVKVHAGQSKEQILLDLSISYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLRDAAQLRSPLPRGIVRIHLLAARGLGSKDKYVKGLIEGKSDPYALVRVGTQAFCSRVIDEDLNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDDWFPLQGGLGQVHLRLEWLSLLPHAEKLEQVLQWNRGMSSRPEPPSAAILVVYLDRAQDLPLKKGNREPNPVVQLSIQDMTQESKAVYCTNSPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTVPLARLLTAPELTLDQWFQLSSSGPNSRLYMKLVMRILYLDSSGVHFPTVPGSPGAWDPDSENPQTGSSVDAPPRPYRTTPDSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGQSFRSRVVREDLNPRWNEVFEVIVTSIPGQELDLEVFDKDLDKDDFLGRCKVGLTAVLNTGFLDEWLTLEDVPSGRLHLRLERLTPRASAAELEEVLQVNSLIQTQKSAELAAALLTVYVERAEDLPLRKGTKPPSPYATLTMGDASYKTKTLSHTSAPVWEESASFLVKRPHAESLELQVRGEGGGALGSLSLPLPELLAAEQLCLDQWFALNNGQGQVLLRAQLRVLVAQHSERGAPSLSPSSSSLSEEPELWGGLTHGPSSAPQLRQRLPHADRPQDAPAGPPGQVGQVQLTVWYHAEERRLVSIVHGCRALRQNGRDAPDPYVSLLLLPDKNRATKRKTSQKKKTLSPEFNERFEWELPLDEAQRRKLDVSVKSNASFMSRERELLGKVQLDLAEIDLSQGTAQWYDLMDDKDKGSS
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MRICIVGAGAIGGWLGAKLIQAGAEVTMIARGSHLAAIIEHGLTVEYRDGRREVVRPALATSDMTVAGPHDVVIVAVKAQSLPTLAAPMRALYGPDTAVVYAQNGIPWWYFFRHGGPYEGRRIEAVDPGGVIAAHTEIERVIGCVVYPAAAIERPGVIRHIEGNRFTLGEPDGSRSERVVRLSKLLESVGLRAPVKTDIRNEIWLKLWGNLSFNPISALTRATIDRIIADQGTYNLAATMMAEAQQVAEQLGIRFPVSIERRIRMAEEIGAHKTSMLQDIEAKRPTEIDALLGAVVELAELTGTPTPTLRAIYAVTSLLDRINCES
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MNLTVKTLKGGKFTVEVEAEKTVAEVKVAIQTNKDLPASSMKLIHSGKVLKDEDKIESCNIKPNDFLVVMIAKVSSWLCTIAKAATPAPTAAAATESTTVAVPATPAAATNPPTPGAPSASTSNAAAASTPAATTAPASSVSSPDEFPAEVIDNLKALGFPESEVRVCLRASNGNPDVAVEFLMNGIPPGIGGGSQPAAATSGGASSSGAGNGGPLDALRSHPQFDDLRRLVQTNPSTLQAVLSQIGQQQPDLLQAINANQAEFLQMMNEPMISAMPQEQVQQYMNMAMQAQVLRLSEEEMAAVDRLTEMGFDRSEAAQAYLACDKNEALAANLL
The following text describes a protein:
Function:
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
Sequence:
MADGAARRPRPGSRRGADATGTARWGRAECWAMEAGEDRVLYFAYGSNLLRERLLLRNPSAALYSRGRLQDFKLTFGHHQGRTSSIWHGGTATIVQSPGDEVWGIVWKLNASNISSLDEQEGVEDGIYVPIEVNVHTEEGKVLTCRSYQMKDYVCGPPSPQYKKVICMGAKQNGLPTEYQKKLEAIETNNYAGPVPILEEIEATIKANKINFA
The following text describes a protein:
Function:
May play a role in septum formation.
Miscellaneous:
MISCELLANEOUS: Has been detected in culture filtrate but no signal sequence is predicted by bioinformatic programs.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Secreted.
Sequence:
MLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVTAIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEHRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPTPRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG
The following text describes a protein:
Function:
Imine reductase that catalyzes the NADH-dependent reduction of iminosuccinate to L-aspartate. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Thereby BhcD regenerates the amino group donor for the first step of the BHAC.
Miscellaneous:
MISCELLANEOUS: Iminosuccinate is a labile compound that spontaneously decays into free ammonia and oxaloacetate in solution; MISCELLANEOUS: The beta-hydroxyaspartate cycle (BHAC) consists of BhcA, BhcB, BhcC, and BhcD enzyme activities. Overall, it converts two molecules of glyoxylate (C2) into oxaloacetate (C4) without the loss of carbon as CO2, under consumption of just one reducing equivalent and regeneration of the catalytic amino donor, which makes it one of the most efficient glyoxylate assimilation pathways. This cycle is of ecological importance in the assimilation of phytoplankton-derived dissolved organic carbon in marine environments by marine Proteobacteria, and suggests a trophic interaction between autotrophic phytoplankton and heterotrophic bacterioplankton. Oxaloacetate formed in the BHAC can directly enter the tricarboxylic acid cycle or serve as substrate for anabolic reactions.
Sequence:
MLVVAEKEIAGLMTPEAAFEAIEAVFASMARRKAYNFPVVREAIGHEDALYGFKGGFDASALVLGLKAGGYWPNNQKHNLINHQSTVFLFDPDTGRVSAAVGGNLLTALRTAAASAVSIKYLAPKGAKVLGMIGAGHQSAFQMRAAANVHRFEKVIGWNPHPEMLSRLADTAAELGLPFEAVELDRLGAEADVIVSITSSFSPLLMNEHVKGPTHIAAMGTDTKGKQELDPALVARARIFTDEVAQSVSIGECQHAIAAGLIREDQVGELGAVVAGDDPGRGDAEVTIFDGTGVGLQDLAVAQAVVELAKHKGVAQEVEI
The following text describes a protein:
Function:
Function in mitochondrial RNA splicing in the excision of mitochondrial group I introns aI5 beta from COX1 and bI3 from COB transcripts and thus would be involved in obtaining the correct structure of the intron, to allow the RNA catalyzed reactions to occur.
Miscellaneous:
MISCELLANEOUS: Present with 5240 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSPKNITRSVIPAIDLYCRKANFKTLKSLSMILGSKKEWYDTKKAPLRTFLVSRCGIFEQLRGRLVEDGKVNLFSVFLTNDSFSFCKMTVDDKFNTSLVDWQKIPFDSTFATDRRQNISLLPVDTLFATEKIISILGVSPNMTNLVSIERERSDLVDFNCKLQSNILEHLLYAKCQGVYVTSTNEKARLLAAVCNPEFIDTFWCELTPIRVSLKENPSISVPREYQMYDPVVRATIKEVVTKRLLRSAFDNDIDPLMCLHLDKGWKLKFPILSSTTGLNFSLKDCLSLDTGKDASDMTEVFLATMESSKVLRTYSNLVDIVMKDNGRLDSGVLKQFNDYVKQEKLNLQHFQAGSSKFLKGAKI
The following text describes a protein:
Function:
Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid and in nodule peribacteroid membranes. Specific for alpha-glycosidic linkages.
Subcellular Localization:
Plastid, chloroplast outer membrane.
Sequence:
MASHSHSQPSNTFTSISHRWREDLRLIRDRANSFTTRNLPSTTFDDVDFVKNLRPKLSEFPKRTSIRMNLSAIRDAIVSEVEEDMDGILGNNKRFNCSEFWKGDEQQWCKDWEPIRVFKKQFKKNTQFLDKLKLSLKSMCNETEDSKEVRPLDVSELLAYFVRQSGPFLDQLGVKRDICNKIVEGLYGRRKNQRQLHSFSGGESSVLGDGNLNDELDLRIASVLQSTGHRYDGGFWTDHHAKHDLSDNQRHVAIVTTASLPWMTGTSVNPLFRAAYLSQSLKQKVTLLIPWLCRSDQEQVYPNNLTFLSPEEQEVYIRNWLEERIGFEAEFKISFYPAKFSKERRSIMAAGDASKYIPARDADIAILEEPEHLNWYHHGKCWTKKFNHVVGIVHTNYLEYIKREKNGALQAFFVKHINNWVTRAYCHKVLRLSAATQDLPKSVICNVHGVSPKFLKIGEEIDADRELGQKPFTKGAYFLGKMVWAKGYKELIHLLAKHKNDLDGFKIDVFGNGEDANEVQSTAKTLDLNINFQKGRDHAEDSLHGYKVFINPSVSDVLCTATAEALAMGKFVVCADHPSNEFFRSFPNCLTYNTSEEFVAKVKEALENEPRLLTPEQRYQLSWDAATQRFMKYSELDRVVNIEKGATKSNKNNGKLIANSLSVPSLTELVDGGLAFAHNCLTGNEFLRLCTGAIPGTRDYNKQHCEDLQLLPPQVENPPYVW
The following text describes a protein:
Function:
Part of a signaling pathway that enables adaptation to osmotic stress through cell wall remodeling and virulence factor production. Phosphorylates the osmosensory protein OprA, which inhibits binding of OprA to Rv2638, leading to the regulation of osmotically regulated genes, including the ESX-1-associated virulence factor espA. In addition, directly phosphorylates the alternative sigma factor SigF and its regulator, Rv1364c, which regulates the SigF-Rv1364c interaction. Can also phosphorylate the FHA domain of Rv1747; Key microbial factor required for central nervous system tuberculosis. Required for invasion of host brain endothelia, but not macrophages, lung epithelia or other endothelia.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSDAVPQVGSQFGPYQLLRLLGRGGMGEVYEAEDTRKHRVVALKLISPQYSDNAVFRARMQREADTAGRLTEPHIVPIHDYGEINGQFFVEMRMIDGTSLRALLKQYGPLTPARAVAIVRQIAAALDAAHANGVTHRDVKPENILVTASDFAYLVDFGIARAASDPGLTQTGTAVGTYNYMAPERFTGDEVTYRADIYALACVLGECLTGAPPYRADSVERLIAAHLMDPAPQPSQLRPGRVPPALDQVIAKGMAKNPAERFMSAGDLAIAAHDALTTSEQHQATTILRRGDNATLLATPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSATVAGPLAADSRGGNWPSQTGHSPAVPNALQASLGHAVPPAGNKRKVWAVVGAAAIVLVAIVAAAGYLVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGMYGRVVKLATGSTGTTVLPFNGLYQPQGLAVDGAGTVYVTDFNNRVVTLAAGSNNQTVLPFDGLNYPEGLAVDTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYVTDTDNNRVVKLEAESNNQVVLPFTDITAPWGIAVDEAGTVYVTEHNTNQVVKLLAGSTTSTVLPFTGLNTPLAVAVDSDRTVYVADRGNDRVVKLTS
The following text describes a protein:
Function:
Transcription activator. Binds to 5'-CAACTGTC-3' and/or 5'-TAACAAA-3' motif in target gene promoter to promote their expression (By similarity). Together with MYB97 and MYB101, functions as a male factor that controls pollen tube-synergid interaction in fertilization. Required for pollen tube growth arrest and sperm cell release in the female gametophyte, probably via the regulation of pollen tube-specific gene expression.
Subcellular Localization:
Nucleus. Note=Detected in the vegetative nucleus of pollen tubes.
Sequence:
MIMYGGGGAGKDGGSTNHLSDGGVILKKGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLARCGKSCRLRWANHLRPNLKKGSFTGDEERLIIQLHAQLGNKWARMAAQLPGRTDNEIKNYWNTRLKRLLRQGLPLYPPDIIPNHQLHPHPHHQQQQQHNHHHHHHQQQQQHQQMYFQPQSSQRNTPSSSPLPSPTPANAKSSSSFTFHTTTANLLHPLSPHTPNTPSQLSSTPPPPPLSSPLCSPRNNQYPTLPLFALPRSQINNNNNGNFTFPRPPPLLQPPSSLFAKRYNNANTPLNCINRVSTAPFSPVSRDSYTSFLTLPYPSPTAQTATYHNTNNPYSSSPSFSLNPSSSSYPTSTSSPSFLHSHYTPSSTSFHTNPVYSMKQEQLPSNQIPQIDGFNNVNNFTDNERQNHNLNSSGAHRRSSSCSLLEDVFEEAEALASGGRGRPPKRRQLTASLPNHNNNTNNNDNFFSVSFGHYDSSDNLCSLQGKTKTTYNTSNLNYSSLQVKCKMFMIKTQI
The following text describes a protein:
Function:
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSGKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDISKEFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQIRFELTCYSLAPQIKVIAPWRMPEFYNRFQGRNDLMEYAKQHGIPVPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNSPDMLEIEFKKGVPVKVTNVGDGTTHSTALELFLYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPVDATGFININSLRLKEYHRLQNKVTAK
The following text describes a protein:
Function:
Probable lipid transfer protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLTTNTLAVLLLLFLSLCSGQSPPAPEPIAADGPSSPVNCLVSMLNVSDCFSYVQVGSNEIKPEAACCPELAGMVQSSPECVCNLYGGGASPRFGVKLDKQRAEQLSTICGVKAPSPSLCSVLGFPTISPAGSEDSSSGSEGSDKDKKNGAMTTKYCGVALNSLALLLLFTFLSLS
The following text describes a protein:
Function:
Regulates pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSSFDKNDERAQLMVPKSINEGKVVKLSQKTLVTKKIERQVVPEEKYIAGLDKIIEKDYFPHLKKMQAQKEYLEAVANKDINKIKELQMKFCSTGSVRTDRSFRTPITTRSTTEAPDVSSFDADTPGPSSASTSSAHDWMQSPMPFANEEGDNEALNRKRKKKKEETLTSYLNKYTSEDNASFEELAKVMREREDARRPWVYKAEEEHNKNLVTRQAIAAEADVQLALKHAVDADDNRPLNVDNWAYKAWNTVLFNPDGAALTPAEIADAARKQQTEINKRGTRFPDSGKLKPSDEAMTRAAVSHALANAGKVDFLGNEVTPANSFKLLETPNPNPDDMDSPLMTWGEIDGTPFRLDAPDVTEHSLPGAAPVFKIPEVPYREKIAQSMNDSIAAKYRDKRKVAMRAAEGAHFSRTPGFGSKRVSDKLAQLSPAAQKLATKKLGLKMLPAHKSPFASPKIMSNWSRPSSSKRSTTPGSAWSRGSTTPGSSWSQGAQTPGTPGIESMIRRKGDNVGPSTSAGAADRANAGDFF
The following text describes a protein:
Function:
As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism (By similarity). Stimulates the activity of a cognate strand exchange protein (SEP1).
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MASETPRVDPTEISNVNAPVFRIIAQIKSQPTESQLILQSPTISSKNGSEVEMITLNNIRVSMNKTFEIDSWYEFVCRNNDDGELGFLILDAVLCKFKENEDLSLNGVVALQRLCKKYPEIY
The following text describes a protein:
Function:
Repair polymerase. Involved in gap-filling in DNA non-homologous end joining (NHEJ) required for double-strand break repair. Can incorporate a ribonucleotide (rNTP) into a primer DNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKILASSTNYVLHNRLSNSQYEDARSKIVNFGGEFTNDAAKADYIFVNYSQINRVRRELRTIGTPLETCVSCKLIVKIDWLNEPKESLTPGNPYVIWHRKPEMKVGSPYTPSTRPASHTEAPNDFENHETPNTENNNEVKSIDNVDQEGSVYPTTKEYPYVLEIPRYACQRKTPLKCVNQAFVNALSVLKTCREVNGESVRTRAYGMAIATIKAFPLPIDSAEQLEKMPGCGPKIVHLWKEFASTGTLKEAEEFQKDPASKILLLFYNIFGVGASHAAEWYQKGWRTIEQVRKHKDSFTKQIKVGLEFYEDFCKTVTIEEATEIYETIVSRMPDGIKIQSCLVGGFRRGKPVGADVDMVLSPSHTHSTKHLVDVLLRILDEEFQFRLISVQEHSCGGKKGYVMLAVILSNSSKINRRVDIIVVPPAYIGSAVLGWSGGIFFLRDLKLYANSHLGLSYDSFEIINLKTGKDICPDEFNEWKDPVEAEKDIFRYFSLEYIEPKFRNTG
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MINFFGGKAPTAAQPASSTSTAVNGARFASVSTSSSASASAAGQPPLKKTKIAPSPVTVVTTVKKKVAPPTSVEPRDPIAALSGYNSKNALPEEKRRRIIEERLAAQRQKSIESSLEAQLRAPTKSLSKSQSASSTSRRSAASFSKPKTKKPRKKVVDSDSDHDEFGDYGKSSRKPSTAPSTPRASKRTSVDPHPTSDSYQKVGRDGVQPNYTVPRDIRASTSPTNTTAIPIDTQSRPSKPISSADIVTANIKNYGPYFNGLGDAPRAVLEYPGTDASEEFLLLVPKDADEYDPLMELLATVRAIVTHYLTPEQRKAFGSLDSLEVSNNAGMILPSATHGASASTSAVCNMVAALTDSNGINGARAKSADLLDGQGSKAERRNHLVGAGTYKDTGSMTPEPHANGISQTAPVSPTSQTSGISASAGGSSVAKTVLVNNALLRLDSPAPTELSVASDHSSTPAASCGTDPDSILRSFTKARNRRDGPLFMRTLARFNSALAALRDTGALAANIADLGSCTGVPEGIWRLIQDQVYARVVGPRVEELGRYQAFSDNVYGELLPRFMSEIAQLTLLGPEKVFVDLGSGVGNLLIQTSLQTGAEAYGCEMMRIPASLASQQVVEAQLRWAAWGLRGGSAIEAWQGDFGDHGGVRDVLKRADVVLVNNYAFLPKTNENLSLLFLDLPDGAKVVSLKPFVPPDFRLTQRTLSSPLAILRVTERLYTSGCVSWADGGGKYYIQEVDRSLVREFLQNAGAATRAKRGKVSEGDDTVAASDLMVGQDVRRKRWKAALQDDDEDDDEF
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Miscellaneous:
MISCELLANEOUS: Deletion causes telomere shortening and senescence.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MKILFEFIQDKLDIDLQTNSTYKENLKCGHFNGLDEILTTCFALPNSRKIALPCLPGDLSHKAVIDHCIIYLLTGELYNNVLTFGYKIARNEDVNNSLFCHSANVNVTLLKGAAWKMFHSLVGTYAFVDLLINYTVIQFNGQFFTQIVGNRCNEPHLPPKWAQRSSSSSATAAQIKQLTEPVTNKQFLHKLNINSSSFFPYSKILPSSSSIKKLTDLREAIFPTNLVKIPQRLKVRINLTLQKLLKRHKRLNYVSILNSICPPLEGTVLDLSHLSRQSPKERVLKFIIVILQKLLPQEMFGSKKNKGKIIKNLNLLLSLPLNGYLPFDSLLKKLRLKDFRWLFISDIWFTKHNFENLNQLAICFISWLFRQLIPKIIQTFFYCTEISSTVTIVYFRHDTWNKLITPFIVEYFKTYLVENNVCRNHNSYTLSNFNHSKMRIIPKKSNNEFRIIAIPCRGADEEEFTIYKENHKNAIQPTQKILEYLRNKRPTSFTKIYSPTQIADRIKEFKQRLLKKFNNVLPELYFMKFDVKSCYDSIPRMECMRILKDALKNENGFFVRSQYFFNTNTGVLKLFNVVNASRVPKPYELYIDNVRTVHLSNQDVINVVEMEIFKTALWVEDKCYIREDGLFQGSSLSAPIVDLVYDDLLEFYSEFKASPSQDTLILKLADDFLIISTDQQQVINIKKLAMGGFQKYNAKANRDKILAVSSQSDDDTVIQFCAMHIFVKELEVWKHSSTMNNFHIRSKSSKGIFRSLIALFNTRISYKTIDTNLNSTNTVLMQIDHVVKNISECYKSAFKDLSINVTQNMQFHSFLQRIIEMTVSGCPITKCDPLIEYEVRFTILNGFLESLSSNTSKFKDNIILLRKEIQHLQAYIYIYIHIVN
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHGRVKSVEREKEQQKTDAQRQEELAKVRMYHEVAGKVLAMKRQQLHEPSALPLTSHLLLLNPEFHVVWSYRRQVIDALAKRAQDPAAERHEMAKTELKLTLDALQRNPKSYSAWFQRRWIVDQGLADLKKEIGLCDKLLELDERNFHCWNYRRHVCKLAGVAEEDQLAFTTQKIEQNFSNYSALHHRSITLPEPLTADVLFDEIGLVQQAVFTEPDDQSAWFYYRWLLTSMVELVESSAGDAVGFLKSQVQWLGELLEMETEAKWVVVTVADLHSRLGAITEVHGWEESKKQSVELYERAIALDPDHRRYYEDMMKKSA
The following text describes a protein:
Function:
Inhibits wnt, nodal/nr-1 and bmp signaling in the embryo to promote head formation and anterior neural induction. Within the endoderm, acts as an essential mediator of nodal/nr-1-induced cardiogenesis in the overlying mesoderm.
Miscellaneous:
MISCELLANEOUS: Microinjection of cer1 into blastomeres results in the formation of ectopic heads that contain cyclopic eyes as well as duplicated internal organs such as liver and heart. The heart beats at a rhythm different to that of the primary heart. Based on this phenotype the name 'cerberus' was chosen after a mythological guardian dog with multiple heads.
Subcellular Localization:
Secreted.
Sequence:
MLLNVLRICIIVCLVNDGAGKHSEGRERTKTYSLNSRGYFRKERGARRSKILLVNTKGLDEPHIGHGDFGLVAELFDSTRTHTNRKEPDMNKVKLFSTVAHGNKSARRKAYNGSRRNIFSRRSFDKRNTEVTEKPGAKMFWNNFLVKMNGAPQNTSHGSKAQEIMKEACKTLPFTQNIVHENCDRMVIQNNLCFGKCISLHVPNQQDRRNTCSHCLPSKFTLNHLTLNCTGSKNVVKVVMMVEECTCEAHKSNFHQTAQFNMDTSTTLHH
The following text describes a protein:
Function:
Acts as a heparin receptor in vascular cells. May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Early endosome membrane; Multi-pass membrane protein. Endosome. Cytoplasmic vesicle, secretory vesicle membrane. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Colocalizes with CAV1.
Sequence:
MRNASGFLKTAGAPLVSATWLPPSPPPAMPMVAAGPQMERVDNGSQGAPQLFLTSALARGVSGVFVWTALLLTGHQIYSHLRSYTVPREQRFVIRLLFIVPIYAFDSWLSLLLLGGHPYYVYFDSVRDCYEAFVIYSFLTLCFQYLGGESAIMAEIRGKPIRSSCFYGTCCLRGMSYSITFLRFCKQATLQFCIVKPVMALITIILQAFDKYHDGDFNIHSGYLYVTLVYNASVSLALYALFLFYFATRDLLRPFEPVLKFLTIKAIIFLSFWQGMLLAILERCGVIPEVQAVDGTRVGAGTLAAGYQNFLICIEMLFASLALRYAFPSQVYSEKKNSPAPPAPMQSISSGLKETISPQDIVQDAIHNFSPAYQQYTQQSTHEAPGPGQGGHPSPSTHPGPASGSGGGKKSRNIEKRMLIPSEDL