lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs aurkb/aurora-B toward substrates near microtubules. Activates aurkb.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome, centromere, kinetochore. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes to the equatorial cell cortex at anaphase. Colocalizes with AURKB at mitotic chromosomes.
Domain:
The IN box mediates interaction with aurkb/aurora-B; The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric.
Sequence:
MNDAECLSHLLQVCARKTEEFVRTLDSKHMVWLLEIEEEARKMFSSDFNAEPELMPKTPSQKRRRKKRTSIVPDENRDPSGRRISRRRSSANWSNSVRRLSIRNQNKTNEDSMQEEPAQPKRMTRARAQASIMCPSVVEMALPESPSQLYQKNVQVTISEQDRRSAEQKLVGSATEESEMKTDVLPVPKIAKDTISEIVNTVVPPPVPETPAVPVTPENKSRAAAKLKIAGSSTPIEAAEMVDLTCESPRPANELANEQPLNLTNQSVTPTGSKSDRRSVRRSLVVVKPSSRRSSLASQFSLASKRESMTREAVRKSIRQSIAKKKAAMETSSASSQRSCQSSIEIIDDEITIKIRPETAPSESVSEEAHTIESPRRSLRSRTFKKIAISNLPDSEEPQRRVTRQMVAMDAEPTPETTDDAQNIRRKSYKRAVDELSDDERPSEGERSPPRKKTPSPPCPPSKIVKPPPHMKSFLHTVQKNQLLMMTPGSIGKNIMMKSFIKRNTPLKMDPKEKERQRLDALRKKEEAELQRKQKIEEGKKRKQEELKLRREERLRKVLQARERVEQLEEEKKKKIEQKFAQIDEKSEKVREDRMAEEKAKKKITAKKQEEVECRRRQEEEARKLKAKQMEEEERRHQDLLQKKREEEELERQKKIAEAKRLAEQRQAEQERERQREQQLLAEKERLRAERERIEREKALQLQRELERAAQEKEQQRREAEERKKREQQERLEQERLERLHKEQEAKRLQEEQQRKAKEQAAAASAPVMNVTVDMQNSPACESYEMTPKSYKAPSVKVNEENYGMDLNSDDSTDDESQPRKPIPAWASGNLLAQAIRQQYYKPMDVDRMYGTIDSPKLEELFYKSKPRYYKRTSSAVWHSPPLSSNRHHLAVGYGLKY
The following text describes a protein:
Function:
Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Sequence:
MRLKIGFILRSLLVVGSFLGLVVLWSSLSSRPDDPSPLSRMREDRDVNNPLPNRGGNGLAPGDDRFKPVVPWPHVEGVEVDLESIRRKNKAKNEQERHAGGDSQKDIMQRQYLTFKPQTFTYRDPVLRPGVLGNFEPKEPEPHGVVGGPGENAKPLVLGPEYKQAAQASIKEFGFNMAASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLTEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPIIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPREKRLRKTKTEPYRSPAMAGGLFAIERDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPLYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESKALPYGDISELKKFREDHNCKSFKWFMEEIAYDITAHYPLPPRNVEWGEIRGLETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGPDGSKVMITHCNLNEFKEWQYFKNLHRFTHIASGKCLDRSEVLHQVFISSCDNGKMTQKWEMNNIHSV
The following text describes a protein:
Function:
Probable transcription factor (By similarity). Together with APO1, involved in the temporal regulation of meristem size and identity during both vegetative and reproductive developments through interaction with APO1. Promotes flowering.
Subcellular Localization:
Nucleus.
Sequence:
MDPNDAFSAAHPFRWDLGPPAPAPVPPPPPPPPPPPPANVPRELEELVAGYGVRMSTVARISELGFTASTLLAMTERELDDMMAALAGLFRWDLLLGERFGLRAALRAERGRLMSLGGRHHGHQSGSTVDGASQEVLSDEHDMAGSGGMGDDDNGRRMVTGKKQAKKGSAARKGKKARRKKVDDLRLDMQEDEMDCCDEDGGGGSESTESSAGGGGGERQREHPFVVTEPGEVARAKKNGLDYLFHLYEQCRLFLLQVQSMAKLHGHKSPTKVTNQVFRYAKKVGASYINKPKMRHYVHCYALHCLDEEASDALRRAYKARGENVGAWRQACYAPLVDISARHGFDIDAVFAAHPRLAIWYVPTRLRQLCHQARSSHAAAAAALPPPLF
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Membrane; Multi-pass membrane protein.
Sequence:
MSTLSQQLSQLGGGSTVDRTWKLKQHSKSLIYEPQVAQDQDFSFIHAVGVEGLRDLVSLDSRFAQFENNLFSDTSIDVDRYVQTQEQNDLLDKAISAFLSLIGPYLMLSPAVKALEWLVRRFHVNQMNAEQLLLCVLPYYDQDIYLRVADVIIKLPPLFVFLNKSKSAAQNPPRNLLIRAFSADMRLFELITEYIVGQTTTKTSYQRQLSFWSQFAIYGLVADKADPERMLEIYLPALAKLVVTIDTDCQIAAYMVLTVLGNKMPLNKEVFNALVETIAANWTQKAIKSGILCITQMYQQKQEPEVLPTSVMTALNKAGFQPSDVVALSQKYKMALFTLGYCMALLRNPDAANFKGLEEIISNTQFGSNESTFLMRYIVDWALAKETNTSVAALAAPVIAKWVTRGETVPELDQLELKLQTVFTEAAVEEMEVEEIQEDVDVESLVEQAKKAASQTTTYFSTKTSENYAELSKIFVQLIERGYTMDKFVSMFSSDIASLTFFARIWASPSPLLARLAAVEAAKTIITAAGEADFQNLIPYTCIALSDASQRVRKAAASFAEVLKSKQNKKPIWGVEKIYTNDCSYLGSGDVTVLLNALSLEECILDESFVIRQVSDMISKKKGYKSAFSTAVLAYLGSHAVSQEIIAIRTSLLTLVTSSEEPIVPTTKVVEPLYINPPNDLAYITELIRTVTDKTGIKFLESLIKNDSPIYDEVCDIVTQRLVKLWPTLKGDAHLGLFRFFVDLSLDKDVPFDSLDVLAHVDVPTKVFISLLDDCKVEQNTTSMDAPSDESTKRRRRSSSSTVRNLLQGKLHHIAERNLRKVSLVLELLVASKTTDDALLGPLFTQLGEILTLGTDSNLPIDYCQSLLADVLLNIIRANQHDGASIDRDIRVDIVVSAIRTASNAQIQNKYLLLVAELATVAPTLVLHSVMPIFTFMGANTLRQDDDFSVHVIEQTVARIVPCLAGNTDKVDMLLVSFVTAFPHIPQHRRVKLFGELVRALDASGTKDALATLLFLFAQKSAELKTARKTSEVSAIAKFCDSLFKLFDASKQLAVVLPYVTLVQELYAIIATDPKTKEKEKKTRRQIFLQVDKELEVSPIDFLVVLLESRILPLQAGLVQSPEALKIAENVLTVLIESQYPELLNVILSLLPLPLFVTVAGRLGSSVYKTVLARFSSGSIEEEDTKASDTLLESLHSLLKSTTDTGDLVLLLQIVETVASGFPKCSDALLVTCAGEAVAQLKNSDDDVFIQAVSVLSSLCLRLGARMIGLFPATISSVLARDSSDNLIALSVLALFATFIKRLPSFMVSSLPKIFEFALKCPADTDTRKQLFVVCVETMDSRVVLQTLCDSWKFVEGFENARLFADTLDLAVAEADKKQIHSKADSLITLCLEAFDSSLKLEANTAARVQNLFIKCLIAIVLKLNDKTFRPLFVKIVDWNTPERSTLLFKIVCRLQENLKSIVTSYYGYIIDLALEILNKASAITPALQRNILSSLYSSFRFDREEFWNNEERFTKISDALGAQFPYLTKVAPENSKLLIKAVVALCELASEDQKKQLNDMMIKLLRQAPLYGSRCFAALFNNVGEEFLPFLPQLVPQIAELLESEDEKVESAVRAELIPAVEEVLGESLDRYLA
The following text describes a protein:
Function:
May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction (By similarity). Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway.
Subcellular Localization:
Membrane. Cytoplasm.
Sequence:
MLPEASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNIGMGRPAQRRLNEALKRYRSGVKSKNWVYKILGGFAPEQKEIPPRSDSPLCFHEPEGGLKCLIPEGAVRRGELLGSGCFGVVHRGLWTLPSGQSIPVAVKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLPVALLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRMIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKDRARLPKPPLCSRALYSLALRCWAPHPADRPSFSNLEGLLQEAWLSEGRCVREVTEPGALRMEPGDPITIIEGSLDTATWKGQNGRTLKVGNFPASAVTLADLGGSPVTHPAHRGSPAHGEKCRGGTDGDREKATLQDLPPARSHRTKMPLQRMRGISKSLESVLSLGPRPTGGGSSPPELRRTRAMPQRLPDLPPRPPDLPPRPPIICNSSQPTQPHKARPKRESSHNHRTGAPGASKATVPSGGPLSDPEWQRKVVEVELSVHGVTYQECQVALRTTGGDVASAIRNLKVDQLFHLSNRSRADCRRILEHHQWDLSAASRYILARS
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MHNMFPALTKTLSLQGYKIINSQTGSAAWSCGRRWFSSDKDDHDDVVTRIKISPIKRTNEPLDKKRARLIYQSRKRGILETDLLLSGFAAKYLKKMNEEELEEYDSLLNELDWDIYYWATKNFKTSPLPDKWANSKLLKQLQEFSENKEKEILSMPDLSKYQ
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus.
Sequence:
MRAAKVKAAAADEALAAELAEQQRLEVKDTKMLQLVRDYPEVRALESQLKDAYLRKSRAEQVTDRSAAKALEVEEQRRYMEYLAEQDRLAKAEEEKKHQEDMERFRRHQAAQLEIIRQHRCAAMEEAKQREQERIAVDAVMARVQEQDFLETLARRDRQRRIMEEQDEFCRLRAAIKKAEQDREAKEEAAIRAYLDEQARRKEMDDKMARERDVVKARILEEQGRRIVEEERKKRELEELLQEYYEEERLTKEQMLIAAEKASRDRMAAAVNQENQKLIEQRRLAKEERLAEEMRFRQEAVEQMAAEAKLQQFNRQKQAEIKRQHIAEAQQRLEERRRLKEQEKELERKVEEQNRKQEEQIQEYIRRARAQLLAQHLPQLGSYAPVFALRDEEKLQFLPQSKTADAALPAR
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146'.
Miscellaneous:
MISCELLANEOUS: Present with 2520 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYIIEHMEEGFSEWVILEYSQILREVGAENLILSSLPESTTEKDIPQRLLKLGLRWTTKDLKGINEDFKDLELLKDGRVCLLDPRATIDLQPEDATKFDYFVFGGILGDHPPRDRTKELKTAYPNLLISRRLGDKQMTTDTAIRTTQLIIKDRIAFEDIKFIDYPEFRFNKNEATEMPFRYVLDKEGKPILPEGMLDLIKKDSAQSLDDLLM
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
Sequence:
MHEWALAEAVVKSAIDMAQKKNLSQIKLLFLRVGEVQQIDMEVFNYAIKELSKGTILENSEIKYEIFPAKLVCNNCGNIWSYMESFQGLTDEEKEAIHFIPETIHVYMKCPKCKSADFEIKEGRGVFIEDIK
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADSVYGNGSLSSGHQPHHAWQQVTDKKAKRRQEAKEKKSASSTANGSSTAVDSNQGVFAALDALEGRQAATRYEDDEEDRARHTDDSDEEELRKPANGISAEEKKPKQKKDKKPRVTVAEAASKIDPDDLLQFLEGVSDSFASNLEIQLMRCADYFARAFSSVTTASFQWHNILKENSLVKASEIPLSYVPEPVVKVTGDWLAKRPVSALSKFAVLLLKIVLEEDGASSKGGKQAAVAATGKTQVGILIVLAILLRRRPESLHQNFDTLNVGQLTKVPEQFATLQWTLAQIAHGDLAAALWLWARHLLPLAVAKNASPATRDTVLQFVENVILANPKKGKSVLMNAAGRKGQDRLVPPAALDQVTRAAFPVEAARTKATSRFEAIHPLIKELALTGASKSMKPVAAALLPLSVAEASADDNPRLSREAGDLFVWSLSQNVECFKQWEKLHLPHIQASSRLLAHILHQWPRFQSQLPALELSKTLKVLHEKHKAVLDGNFSGTVATTESEQTDVLTATRAAEAHVRALGRKLARFPTCFTFVALTVVTVGVLLAYLPIVETVDKLDMDSLRAEFEKIKFFN
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Sequence:
MAADYGGGVRAISLSQGGRNSDDDDGSSQHSPRSASGGVVVVGGGSSSSKSKFVSPSGEIIMSKKPRGRPPGSKNKPKPPIVITKNSEAAMKPVVLEISAGSDVIEAIIQYARRRHVGISVLSGSGAVSNVTLVHPAGPHHHPSAPSLLSLLHGPFNLLSLSGSFMDAVPATATCPSSASSKVATSAGGCSSPGSGSFGICLAGAQGQVFGGIVGGKVVAASAVVVVGATFVNPTVLRLPLPGDDHDDHENGVEGGAPAAEYEAQETKPGVNVESHCSVYGGGGGVASSTPMNCQITSVPDQVMPWGPPSRPPY
The following text describes a protein:
Function:
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity). Has little peptidoglycan hydrolytic activity; however it inhibits the synergistic peptidoglycan hydrolysis of RipA plus RpfB.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Localizes to poles and occasionally septa upon expression in M.smegmatis.
Domain:
A penicillin-binding domain is found between residues 420-820.
Sequence:
MNSDGRHHQSSSGAPRGPANPGQRGQVPPDDRLTAILPPVTDDRSAPHADSIEAVKAALDGAPPMPPPRDPLEEVTAALAAPPGKPPRGDQLGGRRRPPGPPGPPGSSGQPAGRLPQPRVDLPRVGQINWKWIRRSLYLTAAVVILLPMVTFTMAYLIVDVPKPGDIRTNQVSTILASDGSEIAKIVPPEGNRVDVNLSQVPMHVRQAVIAAEDRNFYSNPGFSFTGFARAVKNNLFGGDLQGGSTITQQYVKNALVGSAQHGWSGLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRGAYGISAASKAYFDKPVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMVETKALSPNDRAAQVFPETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQTLNTQGLVVTTTIDPQAQRAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVRAYYGGDNANGFDFAQAGLQTGSSFKVFALVAALEQGIGLGYQVDSSPLTVDGIKITNVEGEGCGTCNIAEALKMSLNTSYYRLMLKLNGGPQAVADAAHQAGIASSFPGVAHTLSEDGKGGPPNNGIVLGQYQTRVIDMASAYATLAASGIYHPPHFVQKVVSANGQVLFDASTADNTGDQRIPKAVADNVTAAMEPIAGYSRGHNLAGGRDSAAKTGTTQFGDTTANKDAWMVGYTPSLSTAVWVGTVKGDEPLVTASGAAIYGSGLPSDIWKATMDGALKGTSNETFPKPTEVGGYAGVPPPPPPPEVPPSETVIQPTVEIAPGITIPIGPPTTITLAPPPPAPPAATPTPPP
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MAEESGAAMITLISFDNTRFETMRRLIEEGGGRAGVHNGIPLPQVDATTLAKVIEYCNKHAFVAVPNAAAVVVDVDKQRLPPCKGFAGAHRQGDCRFDQGQAAGGGEVMGLMELACRAINDLVRDRPVEEVRWVLGIIDNGFTVEEEEEIRRENAWAFE
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPPPPHIKPENVLKRAQELIAVGQAPAALNVLHEHVTSKRTRSSPIASLEPVMLLFVELCVDLRKGKAAKDGLYQYKNIAQNTNVGTIEVVLKKFIELAEKKVTEAQAKADEIQSSLESAAPSSNVEDLEAIETPETILLATVSGEQSRDRTDRAVVTPWLKFLWETYRTVLEILKNNARLEVMYQTTALQAFQFCLKYTRKTEFRRLCELLRNHVQNAAKYSAQMHAINLSDPDTLQRHLDTRFQQLNVAVELELWQEAFRSIEDIHTLLSLSKRPAKNVMMANYYEKLARIFLVSENYLFHAAAWNRYYNLLRQSAAALAAGQGTKKENPSVTEADMTKAASFVLLSALSIPVISTSRSRGALVDVDEARKNKNARLTNLLGMAQPPSRAVLFRDALNKGLLKRARPEIRDLYNILEVDFHPLSICKKITPILKQIGADPEMEKYVLPLQQVILTRLFQQLSQVYESVELKFVYELAQFPDPFQITPAMIEKFIMNGCKKGDLAIRVDHTAGVLTFDTDIFSSAKALHSGSAAGSAESEVGSVQRLQNTPAEIARLQLTRLAKTLHVTCMYVDPSYNEARIQAKKAAQARAEAGAAKEHEETLARRVLIEKKKEAATDALQRKQREEETRKRIRNQQLQEAEKQRLLDEQREREKKRLRDEQERIRQQELKKQLEELKSGVKGIDISEIDLEDLDANRLRAIKLAQLEKEKNELNERIRTTAKRIDHLERAFRREELKHIPEDYEAQKKRDMELYEAIKAETLKEAEEKHKEAVALKHRLSRLVPVFSSFRKEVSEKRHEEFEKRRKAAEREFEAKKKQRIKEVQERRRRERAEREAEERRRKEEEERAKREEEERIAKEEERRRILAEEKAKREEERKRLDEIAQRQKQREEEAEARRAARKSGLAEPPTRAAELERPVERTAPRLNLVSRTGSGPSWRERQAAKEAAGAAPAPAAAEAPKEEVQLPRRTGGYVPPHLRSGANASPATPPSNGPAPEKYVPRHMRESSSSQPPSRTQTPPAAAPASSDKPEASPAPQKWVPRWKQQQQ
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MLSEHVQKYRRSKFKEGAFISDPSQVAIPQIKHKNGGKKVMKHISNFRDIAALNGIEASHEYNWIECIETHGGFNKLVASVDSTYLDMGDNIHYLVPEGYDKLALSLNLPISSDIRVEEHFLKGALDLCTLSAMLGTDQRFEASSHGGLSEPLPQFESLKERVKVQKFSLQVTEDPFAIPEGAAGRIRRSIISETGNLQVHYVKVLEKGDTYEIIERSLPKKQIVKKEPFVIVKEESEKTYKLWQYLATKSIPKHHRNFTSLMKKRQVDAKRFSDSCQREVKFKVRRSLKLMRCAAIRTRQLARDMLIFWKRVDKEQYELRKKEEREAAEALKREEELREAKRQQQRLNFLLSQTELYSHFMQNKAGGSAPPDEEDVPDEDEEEDPEEAQLKREALRAAQHAVSQQKMRTNAFDSETVRLRQTSESVLPTDDSSSMDPSKIDLLHPSTMPEKSSVQTPELFKGVLKEYQLKGLQWLVNCYEQGLNGILADEMGLGKTVQAMAFLSHLAEDKNIWGPFLVVAPASVVNNWAEELIRFCPDLKILPYWGPERMILRKNINPKRLYRRDASFHILITNYQILVNEEKLLRRVKWQYMVLDEAQAIKSSSSQRWKTLLSFSCRNRLLLTGTPIQNNMAELWALLHFIMPTLFDSHEQFNEWFSKGIEGHAEHGGALNEHQLSRLHAILKPFMLRRVKIDVIAEMTKKKEEIVPCKLSSRQQIFYQAIKNKISLNELLDGSRGNLNDKKLLSLMNIVMQLRKVCNHPELFERNEGSSYFYFADIPNSLLSPPFGALQDVHYAGKRNPIIFEIPKLVYDGIICNTENSGSICGFQNGYLNRLFNIFLPSNIHRSAIPEVNSSNESVLSSGAFGFTRLSNLCPVEAFFLATSSFFEGLAFSVMRWNRNYTDEIMDAFLDSEDTDIQFSQNDSTRVRAVARLLLSSTKAKPSLLRTKIGTGPSEGPYEALVLSHHDRLASNIRVLRSAYTYIPPARAPPINVSCADRNFAYKFTDEMYDPWVMKLFLGFARTSEFNGPRQPVALHPLIQELNTDLPILEPMLQLPYRIFGSSPPMSNFDPAKMLTDSGKLHTLDMLLRRLRAEGHRVLLFAQMTKMLDILEDYMNFRKFKYFRLDGSSAISDRRDMVRAFQNRNDVFVFLLSTRAGGLGINLTAADTVIFYEIDWNPTQDQQAMDRTHRLGQTKEVTVYRLICKDTIEEKILQRAKQKNAVQELVMKGKHVQDDHLLRQEDVVSLLIDDTQIAHKLKEISMQAKDRQKKRRAKSIKVDKEGDLTLEDLDDATATAEAVDQDKTSKKKKSSHKKHTNTHDNDSTDKNGEPDVGGDHPGSIHTENEQIGEPRPKRSKRLMKSITDKELAAAAGDEEPAENHRAHDYDGTEEVQDGTAA
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MQPSANHTISASRLSAVLAQWQAAAARGDAAAKQCSAWACVFGERSVNTPDNQRGQAILQYLLEAREPVCNTAALITEDVTLILHGAGVRVAAPPTKLEGHTVEVVEGVEAAQARVAALLAGKTVGAPVNEFAIQEGTFASAFTELVRGAVPSESLLSAAPALGELLFVKDDAALGCVEKAAGLCCAVFRRYARDCIANEMAKRDPKTLYDVRQMLYAKLERPNTIQALESLAVDDFSLVTGLPPCLFHKGTYNSQLNVDEDTLKAACNVPIHGDVVVVRFGVKNTGYTAFFGRTLLVASAAPSNAKEAYQFAYDVSAKLMELLVPGARLSDVYAGVMQYARDQNSDLAALLSKNFGFSTGLLVLEARGNISEKGTAIIADGMSFVIRVVLESVPSAGGEGTFDVELTDTVIIRGGVAELKTKVARKLAEVLYEDLDETAAAAEAAQQVHRDLSKITRQGQSDTMIISREAQREQELRQLLSELHAEFLAAGGKKGTQTSTKEYRACDIGRLSFDELTPYNPEDRVPPPESKKGIFVQTDKKVVWLPVCGRAVPFHVSTVNRVDVKAEGGKYTMTVTFHAMQEANVGYKLNPTKVFVKELGYSSSRDMFTDSAIAIQGIQQRIKNEDAARKRALTSASNGRLTVTPNPLRLPTVKIRPPITNANRQNKGCVGNLELHANGLRFSFLGGIPIDMLFENIKHVIFQPAVKSIYVIYHVTLKKPIEINRKNVLEVQFVAEVMESSELASSARRSFEEEVQAEERDEMRIRQTNKQFITFAHAVEERSKIKTQLPTNQFSFDGVHARSMTMFKGNREVLWAISDTPAFTQSVDEVEVVSFERILPGSATFDMSLILKDYNKPVITINSIPRDSLDHIKDWCLSARLYYMETAVNPNWRTTMKEIREDPDWDPWLRGDGWSVLNNETNDEEDEEEDDDSDSDSTYYEDEDDSSDSDDSSWLEDEESDPSSGSDESDEASAASWDELERRAAAKDRQRDMSDDDDYHPRKRQRAGAAAPAPPAAPTTRPSKMPLNMAGRAGGGAVPPARRF
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
Sequence:
MKKITVFLLLINFLIPTTTQSETSEAELLYDPSENIEILDIHNFHTKIENSQTPWLVKFYLGWCGTCQKLSTEWKKFRNEITPWTDLVKVGAISCSDPANTPVCLNSNISAYPTIKYFPENYKSGDDSTVILKGEHLDVKALKKRVIGQIRTEISEKRGQMYPKLSTYEHPNLEKMFEGLGESVKYVVLVVEAPDQCFATEIALNLHKNRNVSVKFAPNTNTDLVNNLQVSTFPSVVVLDRNNNVSKRFTDPEGVAIESFLLSYGLEVNRIEPNTTKKIVPKKLLRLNQRVKKMGDVVFQVDLEAALRYSLKQEVSAVRVITNERLDALRAYLTVVKKYFPFGENNELITQLVKLTSSSEQVQGVEIFQLVQKAETNRAFSSVQTYLGCLGSVSGKRRYPCSLWQLFHYLTVNSDDETNPREVLTAMHGYIRHFFGCGGCSRHFQQMAIERNLSGVSSLKEAVLWLWEAHNVVNQRLKGDVTEDPEFLKDKFPAKLRCVECYEEDGTWRRNEVFEYLKKMYGKFNVRYVGSDTRVLFPDLDNMF
The following text describes a protein:
Function:
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAFPMPPHQTAYDRAATIFSPEGDLYQVRYAFEAVKKGWTSLGIKTNEGVVIAAEKRFIGPLVDIDDIDKIYKIDDHIGVAFAGMGGDGRILIDYARVFTVRHRLLYGEPPPVELVAKVVADVKQAYTQHGGVRPFGVALIFAGVNPDGTTKVYRTDPGGQYFSFKAIAIGSGEQVANEMFEKHYRSDMSLEEATKLALKILYAIIRKTVEDKEKAIATLPDQVELAYITVKERMFTKMTKEQVKEIVDSMREELLQL
The following text describes a protein:
Function:
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Is essential for both homologous chromosomes pairing and crossover formation during meiosis.
Miscellaneous:
MISCELLANEOUS: Plants silencing TPO6A1 have no apparent growth defects during vegetative development, but most of the plant are completely sterile due to empty and shrunken mature pollen grains, and defect in the macrospores.
Subcellular Localization:
Nucleus.
Sequence:
MAGREKRRRVAALDGEERRRRQEEAATLLHRIRGLVRWVVAEVAAGRSPTVALHRYQNYCSSASAAAASPCACSYDVPVGTDVLSLLHRGSHASRLNVLLRVLLVVQQLLQQNKHCSKRDIYYMYPSIFQEQAVVDRAINDICVLFKCSRHNLNVVPVAKGLVMGWIRFLEGEKEVYCVTNVNAAFSIPVSIEAIKDVVSVADYILIVEKETVFQRLANDKFCERNRCIVITGRGYPDIPTRRFLRYLVEQLHLPVYCLVDADPYGFDILATYKFGSLQLAYDANFLRVPDIRWLGVFTSDFEDYRLPDCCLLHLSSEDRRKAEGILSRCYLHREAPQWRLELEAMLQKGVKFEIEALSACSISFLSEEYIPKKIKQGRHI
The following text describes a protein:
Function:
Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.
Sequence:
MRTKKTMCTWQILSNSPNNFHWQRITTTTTHQHASPPSFPLPSMQDLLRQGTPTLPLQDDAVARGEERVLDDGFGFSNSLFTTGSGKKVTISSSGLVRAKTLLDTIDSSIQSPHRTNKLHAIGEKRKQRQEEEDESPQLKLHRVIDSPSVGGGCRALKKNGFEETDAYKQAPIKFHTAGGRSISISKDALQRAQSLLGDVGDLFEGGDAGSSMFSFPFERQADTAASSQRGDCNTPLVRRVLTPARSNCTAKSFTFPLQSSRQRELPPKFPCEGDGNNLITEFDAVGEESGYNSLKSTNACGQKKPLYGWNQAPHSAVHDSSLNGFSSKIDTHAVSIRRPLVDVSNTTNPDQTNNRQPASGKRRLGLRVTVSPFKKPRSSQISVPLEQDIGKSPHDLSQLSSGVSGCKREVSIRYPFQYPRMHIKDFFVVPPLQEKAHFPNLSRQVTSVNAEKYVFYERSGDNGMGAEAFVHLLAHHGASMHFATKEWVTNHYKWIVWKLACYERYYPASSAGKFLTVTNVLEELKYRYEREVNHGHRSTIKKILEGDAPPSSMMILCISSICSSHATESGTCFETQNGTQKAAAVKVELTDGWYLMNAILDVPLSKQHAAGRLFVGQKLRISRAGLCGWNGPVSPLEVSSTVSLLLHINGTYRAHWAERLGFCKIAGPPLAFRCIKSNGGLVPQTLAGITRIYPILYMERLSSGRSVVMSERMENKMMELYNQRRSAVVDGIISEYQKERPHIYYDSDSEGAKIYNMLETAEEPEFLMADMSPEQLNSFATYKAKLNAIRQSEMDKSIEKALKDAGLGSRQVTPFMRLRVVGLTYKTRQDKPKEGIVAIWNPTETQRQELVEGGAYAISGLMPSSSDSDILHLDTRGSSTKWLPLSYNSRKQFKPFFCNRKSIPLTSLGDIPLSNEFDITAYVVHVGGVYISNQQKKQWVFVTDGSIMNGLQSEKLIDSLLAICFCSPLIDHDSFPPINYNLAGSTVGFCNLIKKEKDHTNHIWVADANENSAYYLNFDSTNCSHLRNAASSVRAWANHSSLIIEKLKEKVMYVVGEDCKA