lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to the promoters of genes with functions important for the G1/S (start) transition; primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division and transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSHLFPPSSPVAGKPLESPQKEPGKLANTSVLTLGRKRYNYELEEYPTPDPSSSIGRQSSPVKDITSRLNETKSALSSPSKQEKVLAGPIEIELDASDPSRLAIGRKKSVCNIILPCRKNISRQHAFISYAADRNEIKLECNGTNGLSVHLPYSMQLHLVKPFPTRNFYKLVAEEPLTSQNTKQSHGKTLQKNQNFISFVLAKGETVTFPYIQGSFINFTGVTVCLSLKKVAPYPGDGNNNFDEENSTETEDELCLLTTTSDDFSWQKETPSMKFVPVEHSPRTEQISKPLLIASPALVKNSPISYRTTPQTSFVINQPSTPKKLKRKSISLKNNTIQETPLPKDKIIGTLSASTRSGGINEEESFAAVAKKTKELSSTTAIVSPAQKRLKTSLNIIPEISRSLSERGIRFDDLVHVLCNHLAFSNLQQTPLSQLQNINSNTSQLSKDELKKVLETISCIGIIVREGKDASGKPLEDEYYYDVENDDSDERKILYNSLKGRSRLRSCRKKHKQYFWKRPTK
The following text describes a protein:
Function:
Catalyzes the C7-methylation of 4-demethylwyosine (imG-14) at position 37 in tRNA(Phe).
Subcellular Localization:
Cytoplasm.
Sequence:
MKTLIKRLQDQQDIWKRIEIVGDIVIIGVPFNKKPEDLVEIANEILSTFPYVKSVWGRHRDVNGTYRLSTYVHLAGEKRSETVYKEHKCKYFLDFTKVFFSEKLSYEHLRVATQVKRDEIIINMFSGFGPFSILSAVLGRPKIVYSIDLNPYAYYYMMVNVELNKAYEVLPIYGDAFKRIYELEDADRIIAPLPELADKAYEVALQKVKKGGIIHLYTEVETNKGEDPVRIAMNKYRGSYFGRIVRSVNPHKYHVVVDIKAN
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKMNHFRFDNFSTVPPDPVLTISGYTTGVSAGQSLPLTCTSTQGKPPAHVTWWNGDVEQQQAVYSSTPDSSTYQGDATSVLTLAVQPANNQETYQCRVSQLETELERQNVQLNVRFMTGPPTLTGYSGPINTGSSLTLTCTTGSSNPPASISWTLVGGSASSATFPSDTEGQYGGTITSEQTILPNQRPQDNGSQIKCTATKSELGQSMDSSTVTINVRFYLGGIGITGHTNSVTSGSSLTLTCTSGSSNPPANISWTRVGGAAPTGTDQPQTDGQHGGKITSQQISLTNLQAQDNGAQFKCTVTNSAVSQREEKTVTIDVQYAPTNVQVSCNPSDLSDLREGRRLECTCTADSNPAAQYSWIKDSTAGPLPTGVVLDTTVGTLTFSTLDRTHSGVYSCTANSGISPEATSGGVTLDIKYAPIEPTIVSNATTVEEGDSVQLTCQTTSNPPALYNWTKQSGDLPGDAKEETIGQTSVLVIPGLTKDDSGTYICTASNVVLPGGTAEDYNLTVLYLHQPIVRSNEVSIVDGTLQQAAVGENTNVSITCTADANPTAEIKWTGPQEEVTNEGQLQFNHVERTHAGNHTCKASNSIKGEPRSKEVTLEITVNYPASITCITPPVAVDEYDDVNMTCTADSNPAPDNFSWAYMDGTTLTGTTSVNRFSLTTSITAITYQQAGTYTCTAGNGIGTADSEGTNVTVEYAPKFYPPPDPYPAAIGADVSMQCSAFAVPNSIAFTWSTNGTTLTNSSRLNIQSSRETSVLTIIGVEQVDYGTYNCTAANIKGSSSTTRTLQPLGPPGTPSGLIVLSKNTQFVVRIAWTADFNGGLDTAHIVQLREVGADQWEDVGSRQQTASEQRRTFNITLDLKAQQAGDYQIRINARNTQGEAWSESVDLKLEASQHLSGRMTTNENWVEALKDSESTEFRQKKALWERNLDKVFSSLIGYEGATITQFSQGSVVGDFEAVVAESETQAAIEAFETQVNTGSVGDLTVVKESSQISVTRPPVDGDSTATIIIIAAVVCGVVFLAIIGVGVFVFRRWKSANKKPGQNHQNNIELDRVRDDTDGGYQSLKIPNRRTSDHTYQGLMARSGNETSPDATYEDVKTQSEFPRNQLDIKEELGQGEFGSVYKAEAWKISGNTGVTTVAVKELKGMTGPASSTAFFKELSVLKLLGTHPNVVSFLGCCTGADPFYLLLEYVSGGSLQSNLRTSRTQQTYGNLHGGSKSLSSRDLTKFAWDVAKGMSFLSAKKVN
The following text describes a protein:
Function:
Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate.
Sequence:
MYALTNCKIYTGNDVLVKHAVIINGDKIEAVCPIESLPSEMNVVDLNGANLSPGFIDLQLNGCGGVMFNDEITAETIDTMHKANLKSGCTSFLPTLITSSDENMRQAIAAAREYQAKYPNQSLGLHLEGPYLNVMKKGIHSVDFIRPSDDTMIDTICANSDVIAKVTLAPENNKPEHIEKLVKAGIVVSIGHTNATYSEARKSFESGITFATHLFNAMTPMVGREPGVVGAIYDTPEVYAGIIADGFHVDYANIRIAHKIKGEKLVLVTDATAPAGAEMDYFIFVGKKVYYRDGKCVDENGTLGGSALTMIEAVQNTVEHVGIALDEALRMATLYPAKAIGVDEKLGRIKKGMIANLTVFDRDFNVKATVVNGQYEQN
The following text describes a protein:
Function:
Probable transcription factor which modulates gene expression, thereby acting as an ASJ sensory neuron terminal selector gene.
Sequence:
MGGASSPRIPSRRSAPYFTSLAFFGSSYIKVKNNRNKMLNPTDAASVALSFSVPFQMSGENPLSKLVEHCNKFVPGADIKMKAEPAKPESLLLPTDMNAYSPYLATPNWWVDQTGWPQLYPTVTTASSVDVYQNYLASSQLGGLLSSSVSAVASQLPAGINAQSALNITSQQRTIAKSFQHTKPMASSSSIPSVLTASNSSANSLVSSGSESVSARGTSGSGGTGKYPSSRTANKCECPNCHEIEKFGPNAIAARKRGVHNCHIAGCGKVYNKSSHLKAHLRWHSGERQMKKRSGDSS
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MQEIITNNIPTFKLQNDVDMVEETQPTTPTTQPTTPTTNTISTTTNTITSTLNTNNISPILEESEEEDSNELIIETDENNTSVSATGTTPTSSSSSSSSSPTNTTTTTTTTTTATTANNDFKNITSNNINKTNSNVNTNSEIKNIDNSIMNSLNRYNNITTASPSNSTMITMKSAISSLDEIVKNTMKAQRESFIANEDKESLPEPQTNSNVNGNEEAKDEKEIHLLAKILLNFSSNGIAVPNLSESSPAVLNTKLKDSSNLVPYGGDLNTSVNGVVGNSSGMVDLSASTGDLLGSLNAANKKKRQRTSPEQLAILEQIFETDKMPSQQIRVRLANQLGMSSRRVQIWFQNKRAKVKRGGPFGKGDDNDDLFAEGEDIIDEDEDEDSSLTIDESGNNNNNSGNNNNNNNNGIMGGHGMLSSSPTNLNTSSDNIVPSISPMLTSININSSSSTPTLQSVNLLNNTNNNNNNNNNNNNNNNNNNNNNNNHTTTTTTTTTTTTTSSSPPLTSFNFQLNQSLNKLTSPPSPPSIVPSPNKKTKQMGGFSLNSTASSLPSFPQIKLNSSSKHIPTDKQNNSDFSNFNNNNNNNNNNNNNNNNNNNINNNGNNNSNNNDSNNNNNKSNFSDYQPLKFHNSIVKN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Has no activity against GTP, nucleoside monophosphates or ADP-ribose; Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
Sequence:
MHFVSYSLCYDVRSNIMEQPIYFYEPDENHGFLANFYPCSITVSGTCWPSSEHYYQAQKFDDVRLQEKVLRAEDAAQAFRLSREYQQWQRHDWYDIRVEVMRFIVREKFLQNTPLAHQLLATGDTELKEHSHKDAFWGDGGDGHGRNELGRILMMVREELQEHAPYNLVQFIDSAKLPTQWGTFQMYGFIEKATGKEHLALVYGDIEQQAAPLIRLHSECLTGDALFSARCDCGFQLAKALQNIVAEGAGVLLYLRQEGRGIGLINKIRAYHLQDDGADTVEANEQLGFGADMRDYAFCRGILSFLGIERVRLMTNNPRKVKALQLANIEVTERVPLQEGNNPHNHQYLRTKADKLGHMFDRNFVKP
The following text describes a protein:
Function:
Caudal (cad) is one of a number of transcription factors controlling segmentation of the embryo. Further transcriptional regulation via a 5' flanking region containing DNA replication-related elements (DRE) and by dref also regulated by trh and tgo via the CNS midline element. Alongside Bicoid (bcd), caudal forms concentration gradients down the anterior-posterior (A-P) axis providing positional information and subsequent induction of the gap genes. Plays a role in gastrulation/germ band extension, hindgut morphogenesis, positive regulation of cell proliferation, genital disk development and pattern formation. Acts as a key regulator of the Hox gene network and activates transcription via the downstream core promoter element (DPE) relative to the TATA box. Plays a role in the establishment of the hindgut and in the invagination of the hindgut primordium during gastrulation. These effects on the gut are achieved by acting combinatorially at the posterior of the embryo to activate transcription of different targets including fog, fkh and wg. Caudal is involved in regulation of proliferation through transactivation of the E2F gene. Postembryonically its function is mostly restricted to the intestine where it regulates antimicrobial peptide (AMP) levels preserving the normal gut flora.
Subcellular Localization:
Nucleus.
Sequence:
MVSHYYNTLPYTQKHSAANLAYASAAGQPWNWTPNYHHTPPNHQFLGDVDSSHAAHHAAAAHQMYYNSHHMFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKKGSDPNVMGVGVQHADYSQLLDAKAKLEPGLHLSHSLAHSMNPMAAMNIPAMRLHPHLAAHSHSLAAVAAHSHQLQQQHSAQMSAAAAVGTLSM
The following text describes a protein:
Function:
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity).
Subcellular Localization:
Nucleus; [Isoform 1]: Nucleus; [Isoform 5a]: Nucleus.
Sequence:
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGQGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
The following text describes a protein:
Function:
May be involved in vesicle transport between the ER and the Golgi complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSGNVLFAMITRLRDGLPLSATTDHDPSQRVLESKKYAKIISKKASQFPDRCSMFTGSHWLYFISSLGVCFITMCEESYSSVLAFCFLDELQREFISLYDNKRVDNAVRPYALIDFDRIIQKTKQRYNNPMTLNARQKYSDMTLEVKLRPPYRISIDDLEPTGRRNVNGISAHHIPTWQAVNLSDTEDIPKPTNFRRPFSRLDWMAKLLVFLSVLCGTLNLARIMAVLTFGTSPYEPDEKVIVAQAMALLIIAALLSYYQSFKLWTSLGQRSLRQLLACVLVIVCNYSLYKLYWRFLLTAGFHSLVAVLVAWKMRAGSGDFKLPNYTV
The following text describes a protein:
Function:
Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. Displays esterase activity toward a wide range of substrates, including acyl-CoAs and aryl-CoAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MIWKRHLTLDELNATSDNTMVAHLGIVYTRLGDDVLEAEMPVDTRTHQPFGLLHGGASAALAETLGSMAGFMMTRDGQCVVGTELNATHHRPVSEGKVRGVCQPLHLGRQNQSWEIVVFDEQGRRCCTCRLGTAVLG
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MVTDIASCLPLFPVSHDFIDIINEPAQFREALKKGIETARSRIVLASLYIGTTETDLIEELRMALQSNSQLRLIVLVDYFRGSRIEGNGKSTVNLLEPLRDLYPNQVQISLYKSPAAKRKWMGIVPQRFNEIFGLQHIKAYVFDDDVLISGANISKDYFTNRQDRYVLFRKAGDMALYFTELIQTLANLSEASLKISESRKEYLDRVHNTLESFSAVWLKKTQIFRNQFNTIFKDNLTDSDGCTFAAPALQLGCVGIRYDQKAMLCALSLAREAPDYHISIASGYLNFPSVYRDVLYQSKSDIEVLCSSPQANGFFNSRGISKFVPAAYSYLEWLFGQEFSKRNKWALVRIFEFYRADWTWHAKGLWMYQHADPQSPYVTTIGSSNMNQRSLELDMEAQVYLFTRNSLVRTRFNQNFAHLQSYTKNVQLETIRNRRVPTLVKFCARMLRTMF
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSAMVSALTQVVSARSQTEAEGAHSSSSSAGHKRGWLGIDSAPIPSSFARVDSSHNPIEESMSKAFPEEAREKKRRYRGVRQRPWGKWAAEIRDPHRAARVWLGTFDTAEAAARAYDEAALRFRGNKAKLNFPEDVRILPPPPPLLRSPADTVANKAEEDLINYWSYTKLLQSSGQRSFLERGQEESSNIFEHSPMEQPLPPSSSGPSSSNFPAPSLPNT
The following text describes a protein:
Function:
Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases AGP1, BAP2, BAP3 and GNP1. Binding to promoters is facilitated by DAL81. Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes. May be involved in pre-tRNA splicing.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Localizes to the cytoplasm in its unprocessed form and is targeted to the nucleus after proteolytic processing upon induction by amino acids. The SCF(MET30) ubiquitin ligase complex negatively regulates nuclear accumulation of the processed form in the absence of high extracellular methionine levels.
Domain:
The N-terminal inhibitory domain contains conserved sequence elements important for cytoplasmic retention (Region I) and proteolytic processing (Region II) of the protein. Region I is also required for ASI1/2/3-mediated negative regulation of transcription.
Sequence:
MPSTTLLFPQKHIRAIPGKIYAFFRELVSGVIISKPDLSHHYSCENATKEEGKDAADEEKTTTSLFPESNNIDRSLNGGCSVIPCSMDVSDLNTPISITLSPENRIKSEVNAKSLLGSRPEQDTGAPIKMSTGVTSSPLSPSGSTPEHSTKVLNNGEEEFICHYCDATFRIRGYLTRHIKKHAIEKAYHCPFFNSATPPDLRCHNSGGFSRRDTYKTHLKARHVLYPKGVKPQDRNKSSGHCAQCGEYFSTIENFVENHIESGDCKALPQGYTKKNEKRSGKLRKIKTSNGHSRFISTSQSVVEPKVLFNKDAVEAMTIVANNSSGNDIISKYGNNKLMLNSENFKVDIPKRKRKYIKKKQQQVSGSTVTTPEVATQNNQEVAPDEISSATIFSPFDTHLLEPVPSSSSESSAEVMFHGKQMKNFLIDINSFTNQQQQAQDNPSFLPLDIEQSSYDLSEDAMSYPIISTQSNRDCTQYDNTKISQILQSQLNPEYLSENHMRETQQYLNFYNDNFGSQF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
Domain:
The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
Sequence:
MAAGRLGELWMKFWVPPRPALKVDKKTLERTWKLMEKVMRLCQSDKMKLKNSPPFILDILPETYHHLRLVWSKYEGDDKLPDLVENEYFKIFVDNINKKAKQTIQLFKDNKEKMYDESSTCRRQLNRMSLIFSHNLAELKALFPNGLFAGESYRITKADAAQFWKKNFGSRTIVSWKIFRQALTEVHQVRSSMETFALKTTIDLTRNDYISNFEFDVFTRLFQPWSTLLRNWNCLAVNHRGYMSFMTYDEVKNRLEQYISKPGSYIFRLSCTRLGQWAIGYVTQDKTILQTIPQNKSLCQALIDGNREGFYLYPDGCEDNPDLTSVLTKPPEELIHVTADQYELYCEIGSSFQLCKICTENDKDIKLEPCGHLLCSQCLSAWQMRINSNRDTDGQGCPFCRCEIRGTEPIIIDPYSPNRMKSARRKAEEEKEKEEENKKDRDDDVDLPTNHAPTPPIPTHIPTPPVPDEPVYAAPKKKNQAHPLPSVPGLPPRPSPISSPVHSPNISPRSSVQYGGASNGTGPLSPTPLLPPRRYLNDGSTEEGQQDDPEGSYQNTAALNQQAFDESPLLHSHTTTTGSSSHESGSVTAPATPYTTGAENPANLLYNTEAMERLRQHAATASNRPGNPFRRSISETTDANAALMFSAFAASNNVGEAAGATGDFHIDSFLSSLMGATTTGDHSNNPIYQNQPHLLHNDSSNSSPSSSNLDLTSQFCQALPPPISSQSFCSGPMGGLETAGGGQVKGHGLSPLIMHSGHAGNGAAGGGGDQDTIYLNITPQASTGSHDDDAVQYEWPPPPRSVNDPPPLPPPHSHHVHQQQQAKAQVMREAPEGYELPPASPVIQQQNPLFPKGISYNANQASSNAVPPPINRTSPQTSPPLAQAQGAQGAPAVPPPPLPAQPRPHQPAHPPHLPPSNTPRSTPRPPLPPGAGAATNAGSMEAIIRILTQEGFHREEVVKALDITKNNVPMARRILKELTITY
The following text describes a protein:
Function:
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with cut14, forming a V-shaped heterodimer.
Sequence:
MSDKGIFRTSSTPSIVDVTPDRGERPRKLVRSVLESPSQKDVASIVKIEQTPSRPFFNDFLKKRITDSLNERPNLLNKFMSAQDGTPSKSTGFNERSSQLVSEFTTTEDIENCEETTQVLPPRLVVYELRLTNFKSYAGTQIVGPFHPSFSSIVGPNGSGKSNVIDALLFVFGFRASKLRQSKASALIHKSATHPSLDSCDVEITFKEVNSDFTYVDGSELTVRRTAYKNNTSKYFVNGVESSFSAVSNLLKEKGIDLNHKRFLILQGEVESIAQMKPRAISEGDDGLLEYLEDIIGTSKYKPIIEENMQELSNSDDICAEKESRLKLVLSEKAKLEDSKNSVLSFLKDENELFMKQNQLYRTILYETRNKKTLVQNLLNSLEGKLQAHLEKFEQTERDISEKNEEVKSLREKAAKVKNDCTSEKKTRQSYEQQTVKIEEQLKFLLNKEKKLKKSIEALSFEKSEAENSLSSHDIDSQKLNSEIADLSLRLQQEELSLDDIRKSLQGKTEGISNAIEEKQKAMAPALEKINQLTSEKQILQVELDMLLNKENDLINDVESSQSSLDKLRNDAEENRNILSSKLKVLSDLKGEKKDVSKNIERKKETVHNTYRNLMSNRTKLEEMKASLSSSRSRGNVLESLQRLHESDNLNGFFGRLGDLATIDEAYDVAISTACPALNHIVVDNIETGQKCVAFLRSNNLGRASFIILKELAQKNLARIQTPENVPRLFDLLRFNDQKFAPAFYNVLQNTLVAKNLEQANRIAYGKTRWRVVTLSGQLIDKSGTMTGGGTRVKKGGMSSAITSDVSPASVETCDKQVQLEDTRYRQHLSELESLNQRFTEISERIPSAELEISKLQLDVSACDRLVAGEERRILQLKSDLKSIRNNNERKRNLQNKISNMDKEVEAININNEGLVTEIKTLQDKIMEIGGIRYRIQKSKVDDLHEQLKFVKDKLNKMSFKKKKNEQRSQSFQVELSNLTSEYDTTTESIATLKTELQSLNKYVDEHKSRLREFENALWDINSSIDELVKFIEFESKQMNSVKAERIELENQIQEQRTALSEVGNNENKYLKLMSNLKLHNLTEFCDQTTMDSTFPEYSEDELSSVDKSELVSNISVLKKKTEDREVDINVLSEYRRCNKEAEKRDSDYQSELQKRTDLKKVVTDLQSQRLDEFMYGFGIISMKLKEMYQIITMGGNAELELVDSLDPFSEGVLFSVMPPKKSWKNISNLSGGEKTLSSLALVFALHNYKPTPLYVMDEIDAALDFKNVSIVANYIKERTKNAQFIVISLRSNMFELSSRLVGIYKTANMTKSVTINNKEILTD
The following text describes a protein:
Function:
Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.
Subcellular Localization:
Nucleus.
Sequence:
MGDDGCSLSPAELTEQQLSSQELEKALCEGSVSSPVRSNRGQDQTRLPSAVSQKTEWMHLPTTPGEGQERQRENRFCGIQGHHLVCHSLHASVDKKGRRRIRTTFTPEQLEEMEKIFQITHYPDVYTRDELASKTKLPEGRVQIWFQNRRAKWRKHEKLGNFGELQYMTEVDTVPAPRPSPGGDGTLPHEHTDISFLPGCNLLPTKLLPAGLHQQHFTPYHPASAFTAPFPHVLLCYLPPGHPCIFPNLLPTLRKTLS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTSELIERINKLIDVVDKAINKREFYPPRLTKYETARIIGARALQLAMGAQPLVDIQEVGSVDPVLIAMEELRRGLLDFIIVREMPDGKTMRIRLKELLELERTL
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MSGIPEGEAGAALRALLTDSVVGLAVWDTGLRCVWVNDALERYDGIARERRLGRRPRESLTGDTGELEALVRRVLATGRCVTGREYRVPTAPDSRRDRAFSASFVRLHDDGGHILGVCMLMLVVTDRRWAGDRLAVVSEAGTRVGTTLDVMRTAQELADFTVPLIADYVTVDLTEAVRLGEEPLDRLGRSQGRVPKFRRAGRASVHAGSPESLWLNGEVVYVPETSPFMQVLSSGRPLLHPVLDPSHEAWLADDPARAAKIREFGMHSLLILPIHARGVLLGVAVFVRTSNPTPFDDNDRLLAEELVARAALSLDNARRYTREHNTALALQRSLLPRRVHGGTAMEVAARYLPADAEEGVGGDWFDVIGLPGGRLALVVGDVVGHGVNAAATMGRLGMAIRTLADLDLPPGEVLTRLDRTFIRLTEDEEEGGGEVATMSATCVYAVYDPATRTCALALAGHPPPAVVHRGGDCSFPDLPHGLPLGVGLLPFPTAELELPAGSLLALFTDGLVEERDQDIEVGLRRVGRALTRGASSLEDLGTAVIGTLPATPPPDDVTLLLARGL
The following text describes a protein:
Function:
Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage.
Sequence:
MTIIVVYLAMEEREALKKQIELLQTLINNHKSVHGDAPSGARTWSRPRQATASSQSRSTEFSRSHPAQTRPFESQPPGYWRKKYSLSNKHTAPEGTVVIHTGPAGTAVKSAVSSSVQHLPNQPVGPSSSSGVTADPQITSASATLLSGNSALTARQQSKGLLISKHQAALSSSLLLSSGLNNNLSQQNPVLLLSSQGSDTGLTGKSKTIKNSSLTQAVLIPKGSQNSALPSGPVSTSPQTCGLNENVQPKPSSLPRADSGDGSSGHVKPHFLSKSVKDPKPASSDPASITSHHITKITSSVLSSSSSQTDTGSDAGDKNAGKLLTALPQPSSVWGRAASVKRSRYTWVKKTQEGLAGPSHIEAFKGSGTAKPALSPASQPHAPSLSSGKKRTVAASRTLRISNPSPPPLGTQLPKAAKTQYTWVSAAARPPQPSRKPLSPTQKAGGLSKNLKLRAKPTAPHMVKSKKAGGVSCPQQAQGSKYRWRAAAQTQAAAAASRSVYQWKVEKENGHRAESGHSSVIQAPHSKPVLSPSPSPYKLKSRMKIIRRKSSGSVAVVERRGSADWLMVKTQFSLRRRRQSVGKSPPLARRAPAKGLVPIGRHKLRRLPSASSQGSARTGFSSPSLRNSSTQRVIKTRYKIVTRGAASISPAVHSSPSLSWRVRRIHSARTVLQTRLRAPQDRQPPQRPWRGRSMRWIGGALYRVSANKLCKTPTLPVPSSGSIQHRAGKWADLSGSSIPGTPTSSSRASTSRHIASRAVQRSLAIIRQARLKKQQGREYCMYYNRFGKCNRGQDCPYIHDPEKVAVCTRFLRGTCKQTDGTCPFSHKVSKDKMPVCSYFLKGICNNNSCPYSHVYVSRKAAVCQDFVRGYCPLGEKCKKKHTLLCPDFTKKGACPHGAKCKLQHRQRARGTRPHRPEDSAQRSGSEEALVRSSPAQGSGPALGENTPAEAATSGPEKLPSYISLHSSPGSSEVSTELEVPVSEGTEGTEKRLQIKPRF
The following text describes a protein:
Function:
Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MTETDKKQEQENHAECEDKPKPCCVCKPEKEERDTCILFNGQDSEKCKEFIEKYKECMKGYGFEVPSAN
The following text describes a protein:
Function:
May be involved in thiamine salvage.
Sequence:
MEEKAKAEQKKIGMTETWLKKHRLLYNGATRHPLIISIRDGTINTASFKTWLAQDYLFVRAFVPFVASVLIKAWKESDCSGDMEVILGGMASLEDEISWFKTEANKWGISLSDVVPQQANKNYCGLLESLMSPDAEYTVAITAFWAIETVYQESFAHCIEEGSKTPPELKETCVRWGNEAFGKYCQSLQNIANRCLQKASDEELKKAEVMLLSVLEHEVEFWNMSRGNV
The following text describes a protein:
Function:
Acyl-CoA ligase involved in the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (By similarity). The peroxisomal acyl-CoA ligase 891 converts the intermediate MFDHMP-3C into MFDHMP-3C-CoA which impairs its diffusion from the peroxisome (By similarity). The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC. 5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE. MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB). MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP. The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP). The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate. The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C. After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight. Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps. The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process. Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (By similarity).
Subcellular Localization:
Peroxisome matrix.
Sequence:
MFFSQPTHLAKAEELKQAPPKGVAYSVALPGTEQPGRSPVYRAWNAQKELLTTLDPEVTTAHDIFESTAIRHPKNDCLGWRPYNSTTKSFDPYQWLTYETVQKRRAAFGAGIVELHHKHDCHRPGQYGVGLWSQNRPEWQITDLACVSQSLYSVSIYDVLSEDATEYIINHSELSCVVTSLPHIASLIKLKPSLPTLKIIISLDPLDGGEQAGHSKRAIFESMAAGLGLAIYTIDQVEELGLASKRGYNPPSASDIVTINYTSGTTGPPKGVVLTHGNAVAATSCGLITISQARGDTSASYLPLAHIYARLAEHTAFWGAARIGYFHGNIAELVDDLKLLKPTGFMSVPRLYSRFGSAIRAATVEQPGFKGALSRHIIAAKTANMKNPDPSKATVRHALYDRIWAKKVTAALGLERARYMVSGSAPLDPTLHNFLRVATGTDVLQGYGLTESYASATAQPVYDLTAGNCGSLAPCVEACLVSLPDMEYSVDDKPFPRGELLLRGNNMFREYYKNEEETRSAITEDGWFRTGDVCTIDEKGRFIIIDRRKNVLKLAQGEYISPERLEGVVLSELGYIAQAYVHGDSLQTFLVGIFGVAPDLFAPYASKVLGRTIAPTDLEAVKESLNDDKVRRAVLRDLERVAKKHKFAGYERIRNVSLKVEPFTVENNLLTPTLKLKRPPTVKVYRSLLDQLYEQAVEEQSAPKAKL
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSHQNLFSLILLFILVTRAESTVNRFRILEDESTVDVYHILEGGGEYNTFIKFLKETKVGDRINYKANSSDGVTVLAPTDNAFKNLINSISDDEHKLQQLINYHVISKFYEFDELQTVHNPVETLATGEDNEPLGLNFTGKKNQLNVSSGYVVTNVYEKAISISTDPPLAVYKLDKVLVPSEFIDPKSPSSNDAPAPAKAKNGTSDDDEITADDKPSPITAAATKPNDAKRINVGILCLISCVFLMGQLS