lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MATPTDGLPGTEMTSISFRDQLWLSAYPLDRNLVFDYFALSPFYDRTCNNEQLRMEAIHPLDMTHLSKKTGMEYILHEAQEPHLFVIRKQKRDGPEKVSAQAAYYVLDGSIYQAPHLYNVIGSRVVRSLYHITNAFAQASAKLEKIGTGTDNENEKVVGEADPADVQVKQSTTKFVDMKEVMRVDSILAGIMRKLPPAPPPPAPLVPVNNAAPGTETAQTPAAAEVKQEQTSAGGKQSNIEGGATKRLKIERY
The following text describes a protein:
Function:
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAMSLASQIKLWWNTQNSPTEHSSIPLLKARLSQTWLNKWTIGLLLVSIKLWMFKMSLSGQLDGAESNSERSCSALERSVSKMMSIPHYTATGMNHVIATAIQKFVSGLIKMVLLIITGVQELLIFAVNMLISTYTCLITLVVQGAVSLAVDTSKHVISFVNDTISTVVPEIEKGLNGLADGLNTATNAFVDLGNLITGKQAEEYTGQIDFVKLQLDGLKNVSIPASVNEKLDSVKDKVPDFETVKNEIESLIRKPFQTISKSMNETLATPLNVSDSLKVPALKSAQFCKDANIPEVYAKLNSGLNTGLKVIISLLLILALIMIVPVAWSEWRLWRYHEELWVEQSTVDVKQEKRHAFHTVLFQAQHKYVTMVKQKLAWGKKLYQRNLSQWYWAYILYPYMLTLLLVGLFGILAFLLQLGLLSILKSGLQSLTVPTSEVGADVTETVVREIETWKNDTNLFLNSQETHINKNLLGWVVDSTSTVNTTLSTFIDTMNNGIDSVFKDTPLHGAVQGVTKCLVTLKLQKVADGMGWVSDNAHVTLPRIDKELMSHQDIEQEASEKADYVSDGIARIIKTVEKLLFTELYIALACLGIWLFMCLIALVYVLIKSRDRTTNFEPSRELKFDMVDTSRDINVPRVLPPQITIPKPALFMRNHIPSPATDPFEEYPIRRNKSSSWLFNLKSPVLRKS
The following text describes a protein:
Function:
In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development. Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
Subcellular Localization:
Secreted.
Sequence:
MLLITGGSYRVLCATLVSLFHIVSSDALNVTDPLARTSIQKSYDLTKYLEHQLRSLAGPYLNYLGPPFNDPDFNPPRAGGPETIPSASVDFHLWRNLNDGLRLAENHRAYSLLLCYLRSIDEEVARTELRRSLGRFCTSLQGLVVSIAGVMSSLGYQPPQELVTSSPPTAMGFGRGNDFLRKMEDFWLLKELQIWLWRSAKDFNRLKRKVPSVVAFRVESRGL
The following text describes a protein:
Function:
Enzyme responsible for the N-acetyl-histidine (NAH) synthesis, which is a major constituent of brain and lens of ectothermic vertebrates.
Miscellaneous:
MISCELLANEOUS: Strong histidine N-acetyltransferase activity has been detected in ectothermic vertebrates and not in endothermic birds and mammals.
Sequence:
MKIDTSLNMPQLPEALSQAGLQFSVATEEDFDEIMAMSQDIYGGLDYLPTRYTSWLQDTNRTVILARKHGKVIALESVCVIDDGETMLVEGLRVAPQERGKGVAGVLLRFCAELVKSRYPEVKVCRLTRDDQLGPKDFEKYRIITKQGILLMRFRAEDLKLHLSEFGLEGDNESTLSTFCSSPPPVRLDHTAIQQLYLNSDLLHGVLPNATIIQDWQPFKLLPSNMAILLKKEIDWMVDDMSNPTVASLCTFPFRVPIGDDWYYLNIDMFGKDLALARQQFLYHLQRHTATLKGHVMCQMFLDPPLWKAMAEFCHNTLSVELVKEYTEQCVVECDLI
The following text describes a protein:
Function:
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Sequence:
MSDRGTFDTNVVTVTRFVMEEGRRAKGTGELTTLLNALCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDILSNDMVINVIKSSFTSCVLVSEENEKAIIVEPDKRGKYIVCFDPLDGSSNIDCLVSIGTIFSIYRKAIGEFILVERDVRIKKRGNIYSLNEGYARDFEPAVTEYLQRKKFPEDGSEPYGSRYIGSMVADVHRTLMYGGIFLYPGNAKNPKGKLRLLYEGKPMAFIMEQAGGMASTGFENILDIQPESIHQRAPVAMGSPEDVLEYIAICQKHAKK
The following text describes a protein:
Function:
Palmitoyltransferase that mediates palmitoylation oproteins, such as RRAS and SQSTM1. Catalyzes palmitoylation of RRAS, leading to increased cell viability. Acts as a positive regulator of autophagy by mediating palmitoylation of SQSTM1, promoting affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes; (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MTLLTDATPLVKEPHPLPLVPRPWFLPSLFAAFNVVLLVFFSGLFFAFPCRWLAQNGEWAFPVITGSLFVLTFFSLVSLNFSDPGILHQGSAEQGPLTVHVVWVNHGAFRLQWCPKCCFHRPPRTYHCPWCNICVEDFDHHCKWVNNCIGHRNFRFFMLLVLSLCLYSGAMLVTCLIFLVRTTHLPFSTDKAIAIVVAVSAAGLLVPLSLLLLIQALSVSSADRTYKGKCRHLQGYNPFDQGCASNWYLTICAPLGPKYMAEAVQLQRVVGPDWTSMPNLHPPMSPSALNPPAPTSGSLQSREGTPGAW
The following text describes a protein:
Function:
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Miscellaneous:
MISCELLANEOUS: The Rieske iron-sulfur protein is a high potential 2Fe-2S protein.
Subcellular Localization:
Cellular thylakoid membrane; Single-pass membrane protein. Note=The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.
Sequence:
MDNTQAIAPPSYSRRQLLNFLAGTTVAVTASAGAYAMGKFFVPPAEKGGAGGGIIAKDVLGNPIPASQILAEAPGTRALVAGLAGDPTYLIVKEDGSLDSIGIVDSCTHLGCTFPWNGNDQEFQCPCHGSRYHPDGSVARGPAPLPLKIVQVAVVDDQIFISPWTDLDPRTGEKPWWV
The following text describes a protein:
Function:
Stimulates the secretion of gonadotropins.
Subcellular Localization:
Secreted.
Sequence:
LAQHWSYGLQPGGKRNAENLVESFQEIANEMENLREVKEAECP
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MILARVMVGRLQFVSMGKENITTELQRIKELLPRYRYVAIDTEYPSTVHEVPVGGAGRLTPVACYYALVKANIDEVPILQVGLTLCDEEGNLPVIVDGFNFAHALVHNVPSTDFMGKLAEVLAKVPQPLMWVVFGGAFDFAHMVKMLSVGQPLPKTHGEFMARARHLLHGLAFDAKYMGKHSGRAELCAGGLRTMAAILGMPQLILVSPSLAGPKSHTAFCIFNVMRLVVHGGASYDGLIDGIY
The following text describes a protein:
Function:
Transcription factor required for yeast cell adherence to silicone substrate. Plays a role in resistance to weak organic acids such as acetate and sorbate. Binds in vitro to a nitric oxide-responsive element (NORE) but seems not to be involved in response to nitrosative stress.
Subcellular Localization:
Nucleus.
Sequence:
MSDTTPEKGSVDSVSPSASNGSNTNNPLNNSSPQPLKSNESDKKPKVTRRSVACKSCHSLKVKCTPSDPNNPSAPCVRCINANRICEIDLNQTRKRRKKSEILEAKRQAGQSLPEHKKEKNTPTQSGYNSSENYSSSINNANDSSLTSRYQSPMTFDPTSPMVFRPQASSAVPPISSNLNPQSAAPTPIPTSGIPPQLPSPHESAILRGNTTSPTSKDDEINQLKQRVRFLETELANKRLLANKKGFSNDSPTDLQSPPFVSKFDLESEISILAESSARLTDLTNQLNEAASRRIQLVSAKKPVDLISKGVITVAEAEERLKLYREQIYGRHPLIAIPDNMHAIEFSQSQPFLFNSIMSACNLITKNADKDVVLAIDNEAMTSVAVEVMVVGTKSVELVKAFSVLCLYYNSPELFKQRRYHMLNTICVSLLHDVGIFARPTYSYNQADGTLKQDASSKDKGNDEYRELVLITYFVTVSTCLVLRRSIYARWTPYVEECCSLLENSSQEKHRRLALFARMNNKLDKIHHIVHAPEMPGQKSGVSQYVIQELQRLLSDLKLKIKDNQYSLLSYYYSIEAYLHEPILTKVFKSDTELDGKAMKSIRYCTSSCLNALDEYSKLTPDQIALLPFPFGSRIMYTAGMLLRLRYLILSLPSHIDKELVPKRAVTSIQCVSKLVEQANILNPHNHYLTKMRLVLQLFIQTYATQVLELLSKNGNTPQNFKPDESETQQLRALAREYNDIRKVSKVSLVSDTRSAEPLDVLSYAATFRRENNDKPSAVAGSLRKSFSENDQAIKTPSQCGQFVSANNTPVPQVINSPPISQTNVPVLHQSQSIINGNNRNSAPLAFNNTTTPSLHQFGDVLPPSSMPQPDYRQFRLPSISNTVHYSSNPRLNANLANPDQLENSYQVLNDEFWSNLLSTDSTDRINFTSNNFNGNTSNDEVFFMNN
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MERILRGIMRYRNTTREQMVKEFQKVRDNPEPKAVFFTCMDSRMIPTRYTDTHVGDMFVGE
The following text describes a protein:
Function:
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Sequence:
MTSRRSQEKSYAEAAAAPPPKESASSDVTPAVPADVIYKLLGFTAAMVVGPIGMYFVTVNSGGMSFFHQTSNFSLFETLTRIASPTVAGITAAITANLVLFGYIYVAWLDDREEREAASKRNEKKAQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
TSVMNYPITEGKTGQQMADHLQKHLEDLGAEKSGNFSVDCDTYQYVTNPNKAVHVLHNSETPYSCYSFIDSPSGVHVVTDASFDLLIQKMKQFYIKKQPKIESKGAILTLCDFSIKIGSVVFGQMTTFKGLLIEIEYKPCNIPKEVYSLLKEFCHHVFGSEINFDETNQYFKSNSEVSQTSTDVICQYLDYFLFFKMSSLSLTQPMTGQANKN
The following text describes a protein:
Function:
Muralytic enzyme exposed to host peptidoglycan layer after membrane fusion during viral entry. Functions as an exolysin that cleaves the peptide bridge formed by meso-diaminopimelic acid and D-alanine. Also lyses the host cell late in infection to release the virions.
Subcellular Localization:
Virion. Note=Located between the capsid and the envelope.
Sequence:
MSKDSAFAVQYSLRALGQKVRADGVVGSETRAALDALPENQKKAIVELQALLPKAQSVGNNRVRFTTAEVDSAVARISQKIGVPASYYQFLIPIENFVVAGGFETTVSGSFRGLGQFNRQTWDRLRRLGRNLPAFEEGSAQLNASLYAIGFLYLENKRAYEASFKGRVFTHEIAYLYHNQGAPAAEQYLTSGRLVYPKQSEAAVAAVAAARNQHVKESWA
The following text describes a protein:
Function:
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
Subcellular Localization:
Secreted.
Sequence:
MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSAAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPRSPIKPKIPLSAPRKNTNSVKYRLKFRFG
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for proper head development.
Subcellular Localization:
Nucleus.
Sequence:
MMDVSSMYGNHPHHHHPHANAYDGYSTTTASAANASSYFAPQQHQPHLQLQQQQQHQHLQQPQQHLTYNGYESSSPGNYYPQQQAQLTPPPTSSHQVVQQHQQQQQAQQQQLYPHSHLFSPSAAEYGITTSTTTGNPGTPLHPSSHSPADSYYESDSVHSYYATAAVATVAPPSNSSPITAANASATSNTQQQQQQAAIISSENGMMYTNLDCMYPTAQAQAPVHGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQATQSQMWHHQQHLAGSYALDAMDSLGMHAHMHHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPSYLPAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLIPADILTQHSTSVISEKPPQQQQPQPPELQLKSQGSDLGGNELATGAPSTPTTAMTLTAPTSKQS
The following text describes a protein:
Function:
May have a role in assembling adherens junctions.
Sequence:
MPLLSKCFPCFKFKREEVIDKLDYSNTPLTDFPEVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISLQELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFSVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPLVPLQYLDASTKTQLTCFMLPQVTFKMNSIQAQQQAQEQYEFVYANQQQPHASPSRRICFAEEATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVRLMRSPTPYPKELRQMSKYVRQAQAATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAIYGIAPETTHIYGVYQQPQQMAHPVPTQEYYGLPLVNYEAHYQQLYVEANTPLPTTHLNGDQDYELQPLQQQPMQQQALPTPRLEPPPYHIARVYTKKTPEDLNLYESMRQRKQQQQLQEQTIYQDALNSNSNFKTTAIGAQDVEESVDQLDYQNNISNNLEPNPEEEDQELDDTMSQHSLNSTATNNTSKASHKKSTWIFGVHKNPTVKQVTLKWENSIGFDIAELLNQVGIFVSSITPNTNAARLLNLNDKLLEIDGYDLTNANLSDAKRVLLNCGTVMNIMLSRK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MNIYSWESSARPQKGKAKKAGTIVFHPDETVDLSFNRLQKEYPLDKTEHPNSQKASEGQTERKKAPLMTAGTAKNLVKRMGFEALLPCQAQCYRGVFNRRDVILHSRTGSGKTLAYALPIIERHLIMSSFSPPASTGPFLLIFLFSNELAAQTKGVLKKIYPKLNILIAGFDNLEVRRCDVLIGTVRSLDEAIRGRLSKESTRGEKRTRSGRAREEEEEKEEAYCDDPGTDEREGDFASSSVSASNVCAIVVDEVDLTLGPRFSNIGRRMRNLLNFIRKANGSLAKGLLTDYRAHHYVLCGATIPNWVVKAGFLGVKKYYYQLVTVGTAKLPERLECFSMYCPQKARVDRAVQLLSTGNFGRTVVFGTRKQVLKIESFLLTQNLQFSFSSLDPGKDEVERIKAMENFNSGAASVIFCTDLAARGLDFIDVHMVLMLSLPKHNMAVETFVHRAGRTARAGRPGKCLQLHDEREDAAIEVIEKNAHIVFKKYIVGGEGKGSVARKRIKKGNLTPPNDQAKTTFTLTVKNPFRSTKPDAVVPTALDVLKKNIGSLFSNVCNVTEDVSGEIVTFEYPANSSHEVRQKLWKFSLKEVTPQN
The following text describes a protein:
Function:
May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans.
Subcellular Localization:
Secreted.
Sequence:
PGLAFSGLTPEHSALARAHPCDGEQFCQNLAPEDPQGDQLLQREELGLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKEKTGLI
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSGRGRGRGLTSLRAFDASEPGGGRGGRGGQGRGRGYKKPLNANLNYMPRDGGNGNEEDNSAKLAQVRAEDALDEGLGWKLFTTGEDRLGWLMNIQSSHMADKDTGQVVASVDCYFMCQDGSMFKARLAFAPYFYVRVQEGREVEAENYLRRKCEGAVREVAVVEREDLDLKNHLSGIRRRLLRVSTYTVQQLMEVRKEVAPLVAANTRRAATTSAYSMAGGGAGAGGGGGGGGGGASTGGLGGGGAGLGAAEAGLQQLLQGQEAAGGGGRNGGGRGQDIREAFLEMREYDVPYHIRFAIDTDVRVGHWYTVRCHEGVTSLDRRHDLLQRAEPRICAFDIETTKLPLQFPNAEYDQVFMISYMLDRQGYLIVNREVVGADIADFEYTPKPEFEGPFKVTNAANERELLQAFFSHMRSAQPAIYVTYNGDFFDFPFIEARCAVLGLDMHESIGFRCRGGQGSGPGAAKECLSRSAVHMDCMHWVDRDSYLPQGSRGLKSVTKYKLGYDPVEVHPEDMVRLARETPQAMASYSVSDAVSTYYLYMTYVHPFIFSLATIIPMPPDEVLRKGSGTLCEQLLMVEAYRANIACPNKHVGEREAMYRGHLLQAETYIGGKVEALESGVFRADLPLKFKCKPAAYQMLLDNLDRDLGYALVHEAKWGAGQEDAANYAAVREAIAAKLTALRDAPNREEAPLIYHLDVAAMYPNIILTNRLQPSAIVTEEDCAACDFNAPGKRCLRQMEWVWRGEHYSASRSEYLQIKAQLAAETFPPAPPRFPNSGFGGGGGGGGGGGYGGGGGYGGGGGGGADGDMGGPRTWAELGQEEQQKFLQERLKKYCQKVYKRVLDKPVTELRVAGICQRENSFYIDTRANKLVLDLGRTLELDTDGIWCALPGSFPENFKFKNKNGKEFKLSYPCCVLNVMVAQHNTNDQYQTLVQPPPGQPPPAGPPRYTVSSEMSIEFEVDGPYKAMILPASKEEGKSIKKRYAVFNFDGSLAELKGFEVKRRGELKLIKVFQAEVFEQFLSGSSLEECYAAVGAVANRWLDLLDTRGADLTDEELLGYISEATTMSKALAEYEGRKSCAISTANRLAAFLGDERIKDKGLNCTYVIARQPASQPTSERAIPVSIFQAEPAVARAWLRKWCGGDVGSTDGVPDVRDIVDWDYYRERLGSAVQKIITIPAALQGLANPVPRVKHPDWLHKRIRERTDKCQQLKMHDLLARMRNKAAVEAAEAEADGAKAGGGGSQNAGAGADVDDLEDLFGGSGGSGGRKKTAAAKTLGKAAREARAAAADVAEGGAGGGDADMGGEGQDDKENAPAAANQANNNNQQPQPPMWCLALGKLHSVTLVVPRSFLVDSRLQAPELLAAALSAGVAAGGGGAHGLGLEVAAVGGAVALPGGRRPQHLYRVTLPEAAYRSEAPRLAAALSAEHVAGVYEDRLPAALPAVLALGCVVSVAQDSRARPLAAPWRLQDFRMRTTGEVGYLDSEPEPEPAAAAGAAAAPQEAPGLRLGLRHVVLYSSLDGSGRGLFALTAPAQQRGHIILLQPSAAAAREVAPALLERLWREARAAAAAEGGPAEPERLTWEVSYERDALDAGRTLQRALMSYRSAVRAPSVVVVQGPVPAARLRRDMSVLHDMPCLDMPCHADDSRYPPLQWQARAARRALHRCAGAGLWLAERAALCRYAHAPLANLDPSGGGCGAGAGGAGGAGGAGGGEALGGGIGSVADMLMCRRLRDAGLTLPVVDPALPDLGGLETENGPAEPAQSAGIDAPVTPSIADTLLQNLYRWLSSPASPLHDPGLHRAVLVLQHKLFLQLCAELRRLGAVIVAANTNAITICTGKRHVRAAAGYTRFLLDALKGRELFRWLDLHPAAWYHAYMYRDGYNWAGLESAAAPAEWRRLAEAGAGAGTAAAAEEEAGQEGDAAAAADDEPVVKFVWNLKEHLPPAVQQDLVLLLTEFLYLPWREARKALQQQQQQQQAGAAAAGADAGGGSQAVPASQGGSTQAAVASTRAEEVQSTFLGSLVADVFTQRLLARVSVWRAVTPGSAPEWTFPQLAGSYLRPDELGHPALAFVRVATHLLALDGRVGEAVLLLRRQLLKALHVNEFSTEAEFKELCQPFVMPDVICSYCNDCRDLDLCRDEALAQHDWRCRACRQQLDTAGLERRLVGLLRREEAAYQTQDLACVKCKQVTSGHLRSLCGLCGGGLVVTRGPEAAARRLTVFRNLARFHGFGMLRELAGWLLGEEPEEAERERQADAEEAAAAAEGR
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MIILETRGLKYTYPDGTVALQGINIEIKKGKKIAFVGQNGSGKSTLFLLLNGTLKPQEGEILFHGSPFKYDSKSLREIRKSVGIVFQNSDDQIFAPTVYQDVAFGPANLGYSKERIDASVQHALEHVGLTRLKDKPPHHLSGGQKKRVAIAGVMAMEPEVIILDEPLSNLDPVGADEIMDLLNEFNHFGSTIIISTHDVDLAYRWSDYVYLMSNSKLIGQGTPAEVFKEQELLKKAGLRQPTTLEIYHEIERRGLAYGKNSPKTIPELVNTLKPLDLMWVEVPPGVREGENLNIGVMYGEYATQSPYEAINATVLHIHPDGRAIVELKRKGIKAGGVLLYDMDSYSLPEVRQIIKDGEIVFVGAMGKQSKTLAEQDGIHLDVTSGVIDKSILMALCGKRCLILTSGGMVDHALNRTREYVEKSGIEFTVGVVNREGGCKWIEEIDENPGALKI
The following text describes a protein:
Function:
Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Peroxisome.
Sequence:
MSFHPALIIVDVQNDFVHPVYISSGESALEVVPVINRLLENDYKWDTVIATKDVHPKDHLSFTTSHSSTPKPSGTVVNIEAYGHVYKQTLWNSHCVENTPGCEFPDSLNGDRIEFVIPKGSDRLVESYSGFYDAIGRDNGLKAILDKKGITDVFIAGVATDICVKETALHARHWYNTYIISEAVKGSSTESHNQAIKDFRDAKIEVISEKDPILQSVRKV
The following text describes a protein:
Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Sequence:
MMSAEEKFSIVRSVGEECIQEHELLKLLTNKRQPICYDGFEPSGRMHIAQGVMKTINVNKLISAGCKFKIWIADWFAFLNNKMDADLEKIQIVGRYFIEIWKAAGMNIEGGQVEFLWASEEIISRAHEYWPIVMDIARRNKLHMLPGLKKGQEKMSKSDPSNAIFMEDEEADVIQKIDNAYCPPKVVDKNPCLEYINYIVFPWFNEFKVERNAENGGEKTFTSFDELVADYEKGDVQPADLKPALSKALNRILQPVRDHFKTDENAKALFERVKVWTFSSSLYFFTNSLYLLHTVFVLFCRVLKSQNDQNRVVVLSTSTSESAISSRLDEFEP
The following text describes a protein:
Function:
Exhibits lipolytic activity with medium chain length esters as optimum substrates. In vitro, pNP-caprylate (C8) is the optimum substrate followed by pNP-capricate (C10). May modulate the cell wall lipids to favor the survival of bacteria under stress conditions.
Miscellaneous:
MISCELLANEOUS: Overexpression in M.smegmatis leads to change in colony morphology, enhanced pellicle and aggregate formation, which may be linked with the changed lipid composition of the cell wall. Cell wall has higher amount of lipids, with a significant increase in trehalose dimycolate content. Overexpression also leads to increased drug resistance and enhanced intracellular survival inside the macrophage cell line.
Subcellular Localization:
Secreted, cell wall. Note=Cell wall anchored. Binds peptidoglycans via the LytM domains.
Domain:
Contains an N-terminal LytE region, which consists of three consecutive LysM domains, and a C-terminal esterase domain. LytM domains are essential for anchoring protein to the cell wall. The presence of LytM domains results in enhanced rate of protein aggregation at higher temperature.
Sequence:
MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRTFDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRTYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD
The following text describes a protein:
Function:
Amino acid transporter that moves basic amino acids across the vacuolar membrane. Appears to function as an arginine/histidine antiporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSVIAPSFDMANILTELSSFLGALSLGCWVVLLIPQLLENYKNQSGESISDLFLIIWLIGDFFNVLGSIYGNVSSTVLVLSFYYIVSDSTLLMQIYYYRWKAARRIASREHEPLLQSRSLEEGLHAPIGKQQIWWDRLSTRQQFGVMGCVVIVSTIVGNLIISSASSDKSDDDLNAWPFTAGCISSVLYFCARIPQIIKNHKAKSTEGLSIIFFVLASVGNTSYAFSILVFPASDYLNYTYANLPWILGAFSTIFLDIYIFYQFIKYRNHY
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAPSATSPAPEETPDATVLTLRKTLCSESTPLDFRIRALFSLKHLASIPSSSSNIAAIEAIAAAFTSPSALLKHELAYCLGQTRNLECSKYLRAVLENREENGMVRHEAAEALGALGDKDSLQLLKERRDDTTEPVEVSQTCELSVERIEWEHSDAGKAEKLRQSDFASIDPAPPTAEGNSGSLSIEKLEETLLDTKTSLFKRYRAMFALRDLASPPDLPTAVPAVLALAKGLHDPSALFRHEIAFVFGQLSHPASIPALVGSLSNLEEASMVRHEAAEALGSLGDEEGVEDTLKKFLEDKDKVVRDSVIVALDMAEFEKNGETEYAFIPEKEAVAAA
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MFEAKFQVGALFKKIVEAIKELVKNVNLETNGIGISQWIDNDQITQIMDAMHVALAAFKLNGKSLTLGFGFENLQQILRTKIKQLWELKMKNQQHHPLHLNRLDRIGEFQLNLMSLDQEWLRVHETDYSSIIRMSSNLFTKIHRELGNINQAVGIETSKGFMSGFCQTYNSDKLEEYEVFEQRGKIIMIMMDNSNLFNKAPTLSNQLILLMSQDQQLIIEYTIGVMGSLKLYLAPKINDEESQ
The following text describes a protein:
Function:
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Subcellular Localization:
Mitochondrion.
Sequence:
MESFITDKAYINGKWESVADSFEVLNPYNGEVVGRAADCDKALAEATVKHAHVAFQSWKNTCAKARSSILKKWFELILKNQKSLAELITKENGKPIKESIGEVAYAASFVEWLAEEAKRNYGTTIPTPHPNKRLMSIKQPIGVAGMITPWNFPAGMITRKACAAIAAGCTVVLKPAEDTPFSALAIAKLGEEAGLPAGVLNIIPSSREHAPEIGNVICTHPDVAAVSFTGSTATGKILLGLAASTVKKVSMELGGLAPFIVFDSADMNKVIPNAIACKFRYMGQTCVCANRIFVQESVHDEFVSKLVAAMKKELILGDTLDPANSFGPLINEKALEKVVESQVEDAIKNGATVVCGGKRGSLGGTFYEPTLITGVTPAMKCCNEETFGPIAAIIKFKTEDEVIALANDSRVGLAGYFFSNDVAQCWRVAEKLEVGMVGINEGLMSTAEAPFGGVKESGLGREGSQFALDEFTEMKYMCWGVLH
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MATKLKKGMPVVKAWLVISESGQSSIEEIGKHSMMKRTGLPARDLRALDPVLSYPSSILGRERAIVVSLEHIRAIITSKEVLLINYNNPLVVQFVQDLQHRIVFGNNNVTSPHQAMDHTGKEMKDATEVTWGSPSLNTLHSSAKSLSKRRAPTCNFVNMKSQEIEGEGANSTINVSVAAGSKALPFEFKALEACLESACRCLETETRTLEEEAYPALDELTSKISTLNLERVRQIKSRLVALSGRVQKVRDELENLLDDDNDMAEMYLTEKVVARAVDQISTIEEVYDGEREVDDESVDDCSETSTSVKPDIEELEMLLEAYFAQIDGILQKLSGMSEYVDDTEDFINIMLDDKQNQLLQMGVILSTANMILNAGIAVVGFFGMNIHVTLFDGKPIQFWETVIGTCGGCIALFLVLLGWGKREKILAL
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels. PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis. Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline. Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ. Finally paxilline can be mono- and di-prenylated by paxD. PaxQ can also utilized beta-paxitriol and alpha-PC-M6 as substrates converting them to alpha-paxitriol.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDFVLSALQRDSWGIAAIILVSIWALHSFHRSRKLQIPVPYVGKCGILGPWISALQWESKARELVQEGYEKHGNFAFKVALLNRWEVCICNEDMIREYKNLMDNQFSAIAVTSELFQIKWTAPGTEEGAHKISIPLLGKALTWQRNRSAAQNDPYFSEFVEEFLYAWKEEVPVPENGDYELPCFETGARVVAHLTARSLVGYPLCRNPEIVNLFTDYGSAVPTSGFFIAMFPEIMKPFVANFCSAPRISKRLQAILLEEFAKRREEGGIESTDIMGWLRNWTDQNEPGVYGDLEITSSIIATIFGAIHTTTQVLVHCLFELATRPEYVEPLRVEIQSALEEHGGWVKEGIEGMVKLDSFIKECQRFNPLDAGSLARRATKDFTFKNGLTIPEGTFVFAPNGPILFDDTLYPEARQFDGYRFYNLGQKTGKPQDFRFAATNQKYLQFGDGRHTCPGRWMASDEIRLMLAHILMNYDIATKDNKGRPENWIFKKILFPDMKAVVILKARKSVSA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
Sequence:
MGKGLALDIGGTKIAAAVVTESGMLIGRQQIATPRGGAGQLAAALETLIAPYRHQVDFIAVASTGIISGGRLTALNPANLGGLADFPLYDCIRSISDLPCVLLNDGQAAAWAEYQALGDKNDNMMFVTVSTGVGGGIILNKKLLVGQRGLAGHIGHTLSDPHGVLCGCGRRGCVESVASGTAIGAETLGWKQPVSAATVFDMAQQGDAQAGKVINRSAAAIAQMLADMKMALDLEVVILGGSVGLAVGYLERVVAAQKTLPGIYRVPVQEAHHRQDSGLLGAALWARTSL