lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex. When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids. Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components. Links the microtubule cytoskeleton to chromosomes during interphase. Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase.
Miscellaneous:
MISCELLANEOUS: Present with 2836 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Chromosome. Note=Associates with the mitotic spindle and the kinetochore. Localizes to microtubule plus-ends. Associates with origin of replication (ORI) sites during interphase.
Sequence:
MDSASKEETLEKLDQEITVNLQKIDSNLSFCFHKITQDIIPHVATYSEICERIMDSTEWLGTMFQETGLVNLQANAAAPVGNAPVKSLVSNNVGIFPTSAEEASRQSQTDNGPNEADSAVHVNRDVHSMFNNDSIDDFHTANITSTGQILKLPDSSDEDTGSEAVPSREQTDLTGEGHGGADDEQDESTIQRQSRKRKISLLLQQQYGSSSSMVPSPIVPNKMRKQLAHEEHINNDGDNDDENSNNIESSPLKQGHHHPKGQADDNNEGPDEEESTKEVPKPGTIIHFSTNR
The following text describes a protein:
Function:
Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSKAQAESVIKNIIREIAQECATQGQAVSETLVAFIVKAIVLNPENDFNVDRALTRDDVERLIQKCVETLLDNESPSLDTIKMQVYFDMNYTGREEFLTEHKRVLDNRLDIVLREITDSRARTKEELEALYRKMVSFIILKSGLGSPTDINVVREATAALQSIFPQTELGPFLAMVKKDKERQLQELILIVTGIRLFNKDCGKGGEGIDDLPSLLSEAIPETLNNIDQNLGAIRQMAYKYTDSLVNSRQHEGFLQILLDDAHKCNDHSKSVEIELKDRLNGLRTIVQSKTAVPTAQVYPQFIRVAQLWRGLQDELVLLSVLNNILYSLEPFARLHQEIFTDEVLEPYLEYANILSDEERVQYGFCAYTCAIEDRFLLPGDPNIGIIRYKGHNFAFSSQEAAHEFASDPDNYINMATENAKFHPELIQLLELHKQFATISPYGRAADSGKMVEAPVTKADMGTQTDTHILESNIVKSYEWNEWELRRKALKLANLRTKVTHSAQTNLSHFRRDNISQVYLPKENKTQTKKDSYSKVPKPSRYISGLRGCSSEDTVMQTVDLTVTVEEDL
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of MtbC (By similarity). No evidence for expression of this protein has been found after growth under presumably inducing conditions.
Sequence:
KLAEILMMPGKTVSVEQGMEIPVTHDIGTIRLDGDQGNSGVGIPSSRLVGCMTHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMVIPLFYGAMPNMGLYYTPDGPFENPGDLMKAFKIQEAWESMEHAAEHLTRDTVWVMQKLFASGADGVNFDTTGAAGDGDMYGTLHAIEALRKEFPDMYIEAGMAGECVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVCNTNTSKTSAWNLARAVTFIKAAVGASPIPCHVNMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPMGMPISHIMASGMTGMRAAGDLVARMEFSKNMRIGEAKEYVAKKLGVDKMDLVDEHVMRELREELDIGIITSVPGAAKGIAAKMNIEKLLGIKINSCNLFRKQIA
The following text describes a protein:
Function:
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.
Subcellular Localization:
Cytoplasm, P-body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, Stress granule.
Domain:
The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
Sequence:
MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSSSSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGNSLTSFGTEASNSGTLSQSNAVGSAFTQDTRSVKPQLAQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAPVGRRSPVPARPLPPTSQKAIDNQEHRRAEVHKVPRPENEQLRNDKRQVVPGVPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREFADFEYRKTTAFGP
The following text describes a protein:
Function:
Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MEDLPAAGGMAASPRLQAVGPAQSQGAPSEPGCELASRPPQYTIPGILHYIQHEWARFEMERAHWEVEKAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKTPTFESEETKDSEVSPGPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSGSEPNGSVETKNLEQILNGGDSLSLKQKGQANKRNSGDVLETFNFLESADDSDEEDEGDLIEDVPDRREKQQMNKKHKIGNEGLAAELADDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWEKDVLSPTTEVWDVDQGLINKLKEEYTKERKGTKGAKRVNRTKLHDMIADLGEEDLSHIPAEILSPARTPSSRITDHEGGRAEEGAEPFAYTEPIAFPPGSGKPFIMASEDVLESVLGLGDLADLTVTNDADFSYDIPSNKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPTKKSASLDVEPIYTFRAHIGPVLSLVVGCSGEHCYSGGLDSTIQWWKIPSPNVDPYDTYDPSVLAGTLVGHTDAVWGLSHSGVKDSLLSCSADGTVRLWSPPTGTQCIGTYNGNREHGIPTSVDFIGCDPAHAVASFTSGCIVVYDLETSESVIQLSSPSDSGAPFSNHINKIVSHPTLPVTIAAFEDRHIKFFDNKSGKSIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHPSKAFIASAGADALAKVFV
The following text describes a protein:
Function:
Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Subcellular Localization:
Nucleus.
Sequence:
MASKTASKDIITLRGSTAIVSEFFGYAANSILYNRGVYPEESFGRVKKYGLPLLLSQDEGVKTFIANLNTQLSEWLEAGKLQRIVLVIMSKATNEVLERWNFSIETDSEVVEKGVSREKSDKEIMREIQAIMRQIASSITYLPCLDEPCIFDVLAYTDADVAVPFTWTESDPKLIANPQMVKLHSFDTKIHKVDTLVSYKNDEWDEQ
The following text describes a protein:
Function:
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity).
Subcellular Localization:
Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells. In a minority of cells, homogeneously detected in the ER lumen. Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium.
Sequence:
EEGLDFPEYDGVDRVVNVNAKNYKNVFKKYEVLALLYHEPPXXDKASQRQFDMEEL
The following text describes a protein:
Function:
Not involved in actin polymerisation, instead functions to stimulate nucleotide exchange on monomeric actin and influence turnover of the small amount of cytosolic actin microfilaments. Essential for erythrocytic schizogony (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton.
Sequence:
MISGIRVNDNCVTEFNNMKIRKTCGWIIFVIQNCEIIIHSKGASTTLTELVQSIDKNNEIQCAYVVFDAVSKIHFFMYARESSNSRDRMTYASSKQAILKKIEGVNVLTSVIESAQDVADLK
The following text describes a protein:
Function:
Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Relocalization to the Golgi apparatus and the plasma membrane is mediated by Star. In the presence of Rhomboid, Spitz is found only in the Golgi, not at the cell surface.
Sequence:
MHSTMSVQHGLVALVLIGCLAHPWHVEACSSRTVPKPRSSISSSMSGTALPPTQAPVTSSTTMRTTTTTTPRPNITFPTYKCPETFDAWYCLNDAHCFAVKIADLPVYSCECAIGFMGQRCEYKEIDNTYLPKRPRPMLEKASIASGAMCALVFMLFVCLAFYLRFEQRAAKKAYELEQELQQEYDDDDGQCECCRNRCCPDGQEPVILERKLPYHMRLEHALMSFAIRRSNKL
The following text describes a protein:
Function:
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built; The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MNIPSFRPNYYSLDDIAITQERIPCRTTQDLHMMGFLDASEKSPNLSNNHTLELPLWVMLTQDDRNPHFEALVPDIYSAAYKEIYQADANYVELGALCKFYFELGMYLTRYQNNNSVAEMLYTTAQERLKGLKDLCQNVGNDSLNVASKFDFSERLLFNEGTKTNKLFDDWLQERQVHIKSTEIAINIRKRKRSPDGETQEEQQ
The following text describes a protein:
Function:
Embryo-specific aspartic protease that limits programmed cell death during reproductive development. Possesses peptidase activity toward casein in vitro.
Miscellaneous:
MISCELLANEOUS: Ectopic expression of PCS1 induces survival of cells of the anther wall including stomium and septum cells. This leads to a failure in anther dehiscence and subsequent male sterility.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MFSRFHALFLLLVLSVRTYKCVSSSSSSSSSFSFSSFSSSSSSQTLVLPLKTRITPTDHRPTDKLHFHHNVTLTVTLTVGTPPQNISMVIDTGSELSWLRCNRSSNPNPVNNFDPTRSSSYSPIPCSSPTCRTRTRDFLIPASCDSDKLCHATLSYADASSSEGNLAAEIFHFGNSTNDSNLIFGCMGSVSGSDPEEDTKTTGLLGMNRGSLSFISQMGFPKFSYCISGTDDFPGFLLLGDSNFTWLTPLNYTPLIRISTPLPYFDRVAYTVQLTGIKVNGKLLPIPKSVLVPDHTGAGQTMVDSGTQFTFLLGPVYTALRSHFLNRTNGILTVYEDPDFVFQGTMDLCYRISPVRIRSGILHRLPTVSLVFEGAEIAVSGQPLLYRVPHLTVGNDSVYCFTFGNSDLMGMEAYVIGHHHQQNMWIEFDLQRSRIGLAPVECDVSGQRLGIGS
The following text describes a protein:
Function:
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MASELTYRGGAASPSAGAAGAGEYSSAKPASSKPLAWLPRAARYAAAEHRPLFALVGMLFAAALFCLAAPSGSGSGTAAPYSSSGRAAAVSGALTRFSVDPAAHNPGRQFVAGKVPLGLKRKGLRVLVTGGAGFVGSHLVDRLVARGDSVIVVDNLFTGRKENVMHHFGNPNFEMIRHDVVEPILLEVDQIYHLACPASPVHYKYNPVKTIKTNVVGTLNMLGLAKRIGARFLLTSTSEVYGDPLQHPQVETYWGNVNPIGVRSCYDEGKRTAETLTMDYHRGANLEVRIARIFNTYGPRMCIDDGRVVSNFVAQALRKEPLTVYGDGKQTRSFQYVSDLVEGLMRLMEGDHIGPFNLGNPGEFTMLELAKVVQDTIDPNARIEFRENTQDDPHKRKPDITKAKEQLGWEPKIALRDGLPLMVTDFRKRIFGDQDNAATATEGQ
The following text describes a protein:
Function:
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The acidic C-terminal domain mediates interaction with histone H3/H4 complexes.
Sequence:
MDFREILLIASKGQGVNHVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLRRKEEELRQKALEEKKRKEELVKKRIELKHDKKARAMAKRTKDNFHGYDGIPVEEKTKKKQLVESHLNQGTDQEYDVEEEDFIDYNQAELDQDYEEEQEPPKAESKPKAPLKSAPSPMNFTDLLRLAEKKQFEPVEIKVVKKAEDRPLTAEELREREFLERKHRKKKPEPDAKLPPPVLKKAPSHKDIMGTKPSRGAGDRQLASKGLPFPQAEKKFRPSTASEKQAALSSPKSLPGERTKVGSGSSTQPSLREGHNRPVFNGAGKPRPSTCSPSVPKTPASGTQKSASEHKAKKPLPSHPSHSKPGPTVLSHNKSKSPGVRQPGSNSGSAPGQPNPGTARPTLSSGPVPRRQNGSSSSGPEQSAGGIRKLASNSHLSGRTLNGTNGPGRPASSSSGPGRPISGSAGSGRPVGSSGGPGQPVNNPHDLRRPMNSLSSPGRAVSGPGRSISGSIPAGRTVNSGPGRPVSSLGPGRAVSNPGLPTKPRCTVVSETISSKNIISRSSNGQINGMKPLLSGYRSAQGPQRLPFPTGYKRPREYEEDDDDEYDSEMDDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEELKRRKAKKLKRH
The following text describes a protein:
Function:
Transmembrane transporter that exports citrate across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFNLNTKSSKEPEVTEVAVDSTPSSPVTRESSPESSPDNSAVDLEKGKKSKFEMHDQTNLLPRSQLFLVFGAMAFCMLVSFMDQNGISVALPDIAKDLNATDTISWAGTSGLIANTVFQVLYGRLSDIFGRKLVFMIVVCTLVCADIGCACAQTSTQLYIFRAFSGIANGGMSCLTMIVVSDIVTLKERGKYQGILGACVGLGNTIGPFLGAAFTENVSWRAIFYLLAPMGGLCAVVIFFILPSKKPQGSAIQKAKAIDYPGLFCSSVALVFLLVPIAGGGSYYEWDSPMVISMLCIGGVFFIAFFVIEGFFAKLPMMPLRIFGTKALFALMMHSVLLGIAYYGDLYYLPMYMRNIRGWSSMKAAGMSCALVTTQAVTTVISGQYLSRMGRYLEVIYFGFGIWTVGAIMKCFWKRDSNMALLIFSLLFEGAGVGCCFQPTLVAAQALSRKEDRSVVISSRNFLRSFGGAVGLAVCSAILANSLKADLKTKNLPSELYELIVKAPFSLPDLSHYPEYRDQVLDAYMNGSHTVFVFLCPIVGACLLVTVFVKDHGLQTHEKKAAEAKTVEDKDKDESGTDCEDMTKGEVLVSEKEGKLSRNSSSQSMHFGDHTAVNTPAPTGYNTPVVGTLCHNSPNFPPMDHNDVITPLEDFDESPLPPHSPNSSGKRVTIQEE
The following text describes a protein:
Function:
Normally needed for pro-sigma E processing during sporulation but can be bypassed in vegetative cells. Activates SpoIIAA by dephosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Polar septum.
Sequence:
MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGFIYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLLILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAIVEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQAEHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKEGKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPGTVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLSKITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSKQVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQEEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQILVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAAAISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDLSIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDLLIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMTVVVVRIDHNTPKWASIPVPAIFQNKQEIS
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane.
Sequence:
MRALEVMNLSCRYPNSDWILKDLSFYVKAGEALAIVGPSGSGKTTLAHCISGIIPNRIFADLRGSIKVDGEDLSGSSIRERISSIGVVLQNYELQIFGLTVEEDLEISLRGEGNIEWILEFFGLEKYGDYYTHELSGGLKHRLVIASMMLSDPKYIVMDDPLANLDWNGRRIIAKTIELLKKDGKGIVVLTRKLRGLEDVIDRVVHLRQSYENHMIFGEAKIPRMCDGNYGGPIIEFRGVHFRYNKDRDYVLKDITLSIRKGEVFAIMGPNGSGKTTLMKHINGLLKPSRGSVIVKGIDTRSVSPASMSKFVGMVFQNPERYFVSETVWDEAAFGARNLGFGEERVAEALRMLGLLDRKDDSPGSLSMGEKIRLYAASVLAMNPEIIVFDEPTTGQDEDTLRQIREVIEKLSNSGKTVVIVTHDSDFTLSVADRLAILKDGTVYAEGDPSKLLSDDRLVEEAGIEPLSAEVRVNVLQDRVGS
The following text describes a protein:
Function:
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Subcellular Localization:
Cytoplasm, P-body. Nucleus.
Sequence:
MSKLKISPNVLDDLCSRFLLNIPSQEKEDMIRLCFQIELAHWFYLDFFRAENNRLPDCRMKEFAKLVFETYPFLLNPSDVNVDKVLESWKEYKRSVPTYGAILMDSTLEYVLLVQGFWIKASWGFPKGKVNKDEQPEICAAREVLEETGYDITKSIKPNQYAEHLLNEQLSRLYFVRDVPLDTKFGPKTRGEIKNVQWFSVSDLPAHKKDQTPKQNLNIAANCFFMVIPFMKQLR
The following text describes a protein:
Function:
Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
Subcellular Localization:
Endoplasmic reticulum membrane. Microsome membrane.
Sequence:
MRVCVVGAGASGLPAVKACLEEGLDVVCFEKTADIGGLWNYRPGQKDIGGTVMESTVVNTSKEMMAYSDFPPPADYANFMHHSKVIEYIKSYAEKFDLMKHIRFSTPVNRISRNEEGKYIVSLQSGKVEEFDKLMLCTGHHAQPSYPELKNLDKFKGEVVHAYNYTNTKGYEGKDVFLLGIGNSALDIAVDIAKIAKSVTISTRRGTWIFNRVSQGGMPYDVQLFSRYYDILLKKLPHTIANDFMEHRLQQRMDHDLYGLRPDHRFFQQHPTVNDALANLLCAGYITITEDIDTFTEDSVIVKGGREFKCDIFLTCTGYTFGFPFVDSDIVEIKNQQVPLYKYVFPPNSDSVAVIGLIQPIGSIAPIAEIQSRWAARVFSGKCEMPSSQEQVNDIQKKKTAMKRRYFDSIKHTIQVDYMTYMDEIAEVIGCLPPMNQYLFQYPRFWMKLFMGANVPYVYRLVGPNSWDGAEQAIWTVPDRVKKPLKNRQCRTRKHKKRGTTDEYFRYATQKVIATNISILFCSGLLLFCSTTSTLPPVVYFLSFFLFFTLYGATLMWFDLQYDMTTIF
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. Although not essential, addition of ethanolamine phosphate to the second mannose plays an important role in cell separation via the GPI-based modification of daughter-specific proteins.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIVTAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLLNGWLPELALLCALD
The following text describes a protein:
Function:
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Sequence:
MSCTGFWRKLASGEECGAAARLLGAVLAIPAALYGLVVRLRALAYARGLSTVRHLDRPVISVGNLTVGGTGKTPMVAYLARRLMARGKRVAVISRGYGGSLEGETRIVSDGRTIVLSAAEAGDEPVHLATSVPGLMTVIGTDRYTAGLLALEQLDPDVFILDDGYQHLRLHRDLNILLMDCNRPLGNGRTLPAGLLREPQTAVRRADLVVYTRCTGGKAPAVHGMIPSCRAGHALTGAALLPDGEVQPLAALRGLRGVACAGIAEPEGFFDALRREGLDIVAAIPFADHASYGEREVSTLREAAAGADYLITTGKDGVKLSAHLARLLPVYATVLEMRPLDPAPLEAALDKVL
The following text describes a protein:
Function:
Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MVLASSTTSIHTMLLLLLMLFHLGLQASISGRDTHRLTRTLNCSSIVKEIIGKLPEPELKTDDEGPSLRNKSFRRVNLSKFVESQGEVDPEDRYVIKSNLQKLNCCLPTSANDSALPGVFIRDLDDFRKKLRFYMVHLNDLETVLTSRPPQPASGSVSPNRGTVEC
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.
Sequence:
MRENLTRWLYQAMGFQNGLARTQRIESISKATKLNKTEPKEESKPADQMDISTDVKYISWLKEHPSALSSFEEMMDVAKGKWVVVFLDYDGTLSPIVNDPERAFMSDMMRSAVRDVAKLYPTAIISGRSRQKVYGFVKLDDVFYAGSHGMDIMGPAIQASCYDGKYQSKALDQKPKIHSIPYSYSTYLCVRDYILQGNELTVFQPAQDFLPSIEKMLNELEETTSEINGALVEDNRFCISVHYRHVLQEDLGLLEKKVQTLVAKYPGFHLTRGKKVIEIRPSIKWNKGDALVYLLETLGFTNSSDVLPIYIGDDKTDEDAFKVLNSREQGCPIIVSSNPRDTMASYSLRDPSEVLSFLIRLARWGEVSAV