lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity).
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MIRSIIKSSNNLLKSNVAINSNKRFFATEASATSDLLTFSLLSPHQTIYKDKKAQLVTLPGAKGIFGVAKNHVPRIAELKPGVIQINHENGDLEKFFISGGFAFVNPDASCYINTIEAVPIDQLDAEEVKNGLARYTQLYNDAQEENAKAVALIGLETYQQMAFACGVSA
The following text describes a protein:
Function:
Mediates the hydrolysis of some nucleoside diphosphate derivatives, possibly using both NADH and ADP-ribose as substrates.
Sequence:
MDSVSLSEVTVMRRTHLGFMHSFTQPFSGVTISPKFCHSKVVGSRAISSSVSSTKSQYVYGESLAATADSDYKMNGLTLKNRISSVKERLLLDAFDDEYGGVVVDHGRLPSSPTVFTSMLQSSLSDWRRKGKKGVWLKLPVEQSELVPVAVKQGFEYHHAEKGYVMLTYWIPEEEPCMLPGNASHQVGVGGFVLNQYKEVLVVQEKYCTSSNTGLWKLPTGFINESEEIFSGAVREVKEETGVDTDFLEVIAFRHAHNVAFEKSDLFFICMLKPLSDKIIIDNLEIKAAKWMPLVEFVEQPMIKGDKMFKRVIEICEARLRHRYCGLSPHRLVSAFDGRPSSLYYNVVDDDDPSHSNCTAEFY
The following text describes a protein:
Function:
Metalloendopeptidase with a Zn-dependent proteolytic activity and substrate cleavage upstream of hydrophobic residues. Positive regulator of senescence, probably by degrading CCD4, thus participating in the controlled removal of carotenoids from the thylakoid membrane during the senescence process.
Subcellular Localization:
Plastid, chloroplast, plastoglobule. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MAVSVSAPVLSLCYNQSGELSRSLGYRLPKKVGFSSGRRSVSYIGFGAEKVGRFRVRVPICRAVPPLLFKDLDADDFRHPFDKQNTLLLRAIPGLNEFGKALLGSMTEQIMLLENIGTSVLVSKNQLSDLHGLLVEAAEILNIEAPDLYVRQSPVPNAYTLAISGKKPFIVVHTSLIELLTSAELQAVLAHELGHLKCDHGVWLTFANILTLGAYTVPAFGQMIARTLEEQLLRWLRSAELTCDRAALLVAQDPKVVVSVLMKLAGGCPSIADQLNVDAFLEQARSYDKASSSPLGWYIRNAQTSQLSHPLPVLRAREIDEWSRSLEYKSLLKRANRKSTVQKV
The following text describes a protein:
Function:
May be involved in osmotic stress and abscisic acid signaling in a calcium-dependent manner.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
MALPLELESLTEAISAGMGMGVDENALISTLGKSQKEHRKLFRKASKSFFVEDEERAFEKCHDHFVRHLKLEFSRFNTAVVMWAMHPWERDARLVKKALKKGEEAYNLIVEVSCTRSAEDLLGARKAYHSLFDQSMEEDIASHVHGPQRKLLVGLVSAYRYEGNKVKDDSAKSDAKILAEAVASSGEEAVEKDEVVRILTTRSKLHLQHLYKHFNEIKGSDLLGGVSKSSLLNEALICLLKPALYFSKILDASLNKDADKTTKKWLTRVFVTRADHSDEMNEIKEEYNNLYGETLAQRIQEKIKGNYRDFLLTLLSKSD
The following text describes a protein:
Function:
Core component of the SMC5-SMC6 complex that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAKSGGRPSASFIKQRSGSGTILRIKLENFMCHSNLQIEFGEWVNFITGQNGSGKSAILTALCVAFGCRAKGTQRASTLKDFIKTGCSYAVVHVEIKNQGEDAFKPEVYGDVIIVERRITESASSTILKDHEGKKVSSRKDELRELVEHYNIDVENPCVVMSQDKSREFLHSGNDKDKFKFFFKATLLQQVNDLLQSIYEHLNSATAIVDEMEETIKPIEKEINELRGKIKNMEQVEEIAQKLQQLKKKLAWSWVYDVDRQLQEQTDKIVKLKERIPTCQAKIDWELGKVESLRDRLTKKKAKVACLMDESTAMKREIETCHQSAKTAAREKIALEEEFNHKRNGVQKIRDRVRRLERQVGDINEQTMRNTQAEQSETEEKLRYLEQEIEKAETLLSRLKEEENSLLEKASAGRREMEHIEDMIRDHQKRQNNINSNIYDLKKHQTNKVTAFGGDRVIYLLQAIERHHRRFKKPPIGPIGSHVTLINGNKWAPAVEQALGNMLNAFIVTDHKDSLTLRSCANEANYKNLKIIIYDFSRPRLNIPRHMIPQTEHPTILSVLHSDNPTVLNVLVDVSNVERQVLAENYEVGKAVAFGQRLSNLKDVFTLDGYRMFFRGPVQTTLPPIPRKPTRLCASFDDQIKDLEIEASRGKSEINQCMRRKRGAEENLEELESKIRTLKKHRSQAEKVLTTKEFEMRDLKSTVAAENEASSSSSVNELQLEIMKEREEMEEKEAFLEKLQMCLKEAELKANKLNASFENLRESAKGEIDAFEEAENELKKIEKDLQSAEAEKIHYENIMKNKVLPDINEAEANYEELKTKRKESDQKASEICPESEILSLGPWDGSTPEQLSAQINRMNQRLHRENQQFSESIDDLRMMYEKLERKIAKKRKLYQGYREKLMACKTALDSRWGKFQRNASLLRRQLTWQFNSHLGKKGISGHIKVSYENKTLSIEVKMPQDATSNAVRDTKGLSGGERSFSTLCFALALHEMTEAPFRAMDEFDVFMDAVSRKISLDALVDFAIAHGAQWMFITPHDISMVKSHERIKKQQMAAPRS
The following text describes a protein:
Function:
Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, hlb), coa, Dnase, spa and cell wall-associated proteins (emp, eap, fnbA). Acts probably downstream of the agr system in the regulatory cascade of virulence factors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
The following text describes a protein:
Function:
Transforms N(2)-succinylglutamate into succinate and glutamate.
Sequence:
MDNFLALTLSGTTPRVTQGKGAGFRWRWLGHGLLELTPDAPVDRALILSAGIHGNETAPVEMLDKLLSALYSGSLTLTWRVLVVLGNPQALAAGIRYCHSDMNRMFGGRWQSFAESDETRRARELELSLETFFSSGQARVRWHLDLHTAIRGSHHLRFGVLPQRDRPWETDFLAWLGAAGLEALVFHQAPGGTFTHFSSEHFGALSCTLELGKALPFRQNDLTQFNVTSQALSALLSGVETSTSFSPPLRYRVVSQITRHSDKFALYMDAQTLNFTAFAKGTLLAEEGDKRVTVTHDVEYVLFPNPSVACGLRAGLMLERLP
The following text describes a protein:
Function:
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Miscellaneous:
MISCELLANEOUS: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRLLEEKIATPLGPLWVICDEQFRLRAVEWEEYSERMVQLLDIHYRKEGYERISATNPGGLSDKLREYFAGNLSIIDTLPTATGGTPFQREVWKTLRTIPCGQVMHYGQLAEQLGRPGAARAVGAANGSNPISIVVPCHRVIGRNGTMTGYAGGVQRKEWLLRHEGYLLL
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MLSFNSKKQLSQFLAEDIGKGDITSALLPKKKITVRIISRESAIVGGAAHARQIFKIKGCNARILKKDGSKVRPNETIMTISGDAGKILTCERTALNLLTRMSGIATQTNELVKKIPKKTKLYATRKTAPGLRYFDKEAVEIGGGKKHRLRLDEMVMIKDNHIAVGSSLESLIKKAKKKHRKFEVEVENTPDAVLAAKEGATIIMLDNFTPNQIRKTIAVLKNQKLRKKVLLEASGGINSKNISKYGQTGVDIISVGSITNSVKGIDVSLEI
The following text describes a protein:
Function:
Involved in protection against oxidative stresses. May play a significant role in maintaining the cellular homeostasis during stress and virulence of M.tuberculosis. In vitro, catalyzes the decomposition of cumene hydroperoxide (CHP) to acetophenone.
Miscellaneous:
MISCELLANEOUS: Though the Rv2159c protein is a peroxidase, it does not form disulfide bridges between the two catalytic site cysteines.
Sequence:
MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDEGLLTAGWATLRETLLVGQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAAAILAGTAPAAGDPNAPYVAWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLVLLDETFLPGGPRAQQLMRRAGGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSEPIATAFAALSHHLDTAPHLPPPTRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLHAPTRLALLTGLAPHQVTDDDVAAARSLLDTDAALVGALAWAAFTAARRIGTWIGAAAEGQVSRQNPTG
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Sequence:
MKLDVVKQFSTRSDRVKGIDFHPTEPWILTTLYNGKIEIWSYATNSLVKSIQVTELPVRAGKFIARKNWIVVGSDDFQIRVYNYNTGEKVTQFEAHPDYIRSIAVHPSKPYILTSSDDLTIKLWNWDHNWKLEQTFEGHQHYVMSVNFNPKDPNTFASACLDRTVKIWSLGSSQPNFTLIAHEAKGVNYVDYYPQADKPYLITSSDDKTIKVWDYQTKSCVATLEGHLSNVSFAIFHPELPIIVSGSEDGTIRFWNSNTFKLEKSINYSLERAWCIGILPKSNVIAAGFDSGFVIIKLGSEEPLFSMDSNNKLIYAKNSEVYQSVIKPSSSEGLKDGESLNLQQRDLGSIEIFPQTLNHSPNGRYAAVCGDGEYIVYTALAWRSKSYGSALDFVWNSHDSSAACPFAIRESGVSVKIFKNFQEYLTLDLIYQADKIFTGSLLGVKSEGCISFYDWEHGKLVRRVDLDDDIIDVIWSDNGELLAIVTTSNLGEISSTVGVKKNNETYFLSYNHELFEEALANGELDAEEGAESAFDVLYTLPTSESILSGKFIGDVFVYTTGTTNRLNYFVGGEVINLGHFDRKFYIIGYKATDGKLYLIDKSFDVVSWYVNAEVLELQTLVMRGDLEQFATQNIVVEKEHGENGEVEEEEVPDLSTITLENLSEEYSQLISRFTKTELNQLSRFFEKLGYLALSFSLSQDFDSKFQLSLSTGNLKQAYDLLSAQEKETPSLSLANSTKWKKLGDLALNKWNIKLAQESFWLAKDYSSLLLLLSSTQNKSQLIKLAEVCESKGKYNIAWQSWWLVGDVGKCFDLLITSERYTEAVIFGKNYGVDPEKLIKAIELWKQTLHKKNKSKVANRLIDDFSNLQTNGSTGAPLIDLESKQDKDQETTTQPQQEAKEKIEDEAGASEVQREEVENVEAEIQQDDEVTAEEEEEEDA
The following text describes a protein:
Function:
Polymerizes to make up the central tail tube that is surrounded by the tail sheath protein (TSP). Tail tube protein polymerization takes place around the tape measure protein (TMP) and is probably directed by chaperone proteins. Upon binding to host cell, the tail sheath contracts and the tail tube penetrates the host envelope. The tail tube is involved in viral genome delivery during ejection.
Subcellular Localization:
Virion. Host cytoplasm. Note=Tail.
Sequence:
MAGNQRQGVAFIRVNGMELESMEGASFTPSGITREEVTGSRVYGWKGKPRAAKVECKIPGGGPIGLDEIIDWENITVEFQADTGETWMLANAWQADEPKNDGGEISLVLMAKQSKRIA
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of 2-deoxy-D-ribose to 2-deoxy-D-ribose 5-phosphate (dRib-5P), allowing the use of deoxyribose as the sole carbon source. Can also use D-ribose and 2-deoxy-D-ribitol, with lower efficiency. Several ribo- and deoxyribonucleotides can replace ATP as phosphoryl donor.
Miscellaneous:
MISCELLANEOUS: Located in the deoQKPX locus, involved in 2-deoxy-D-ribose utilization. This locus is absent in E.coli K12.
Subcellular Localization:
Cytoplasm.
Domain:
Met-10, which corresponds to Asn-14 in E.coli ribokinase, is a key residue differentiating ribose and deoxyribose.
Sequence:
MDIAVIGSNMVDLITYTNQMPKEGETLEAPAFKIGCGGKGANQAVAAAKLNSKVLMLTKVGDDIFADNTIRNLESWGINTTYVEKVPCTSSGVAPIFVNANSSNSILIIKGANKFLSPEDIDRAAEDLKKCQLIVLQLEVQLETVYHAIEFGKKHGIEVLLNPAPALRELDMSYACKCDFFVPNETELEILTGMPVDTYDHIRAAARSLVDKGLNNIIVTMGEKGALWMTRDQEVHVPAFRVNAVDTSGAGDAFIGCFAHYYVQSGDVEAAMKKAVLFAAFSVTGKGTQSSYPSIEQFNEYLSLNE
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKHKHTSKADFVRKNKKKAQTDVKSNPFEVRINRQKHNVLGKKLRRFDKGMPGVSRSKAIKKRKATLLQEYQQRDKRNQFVDRRLGENDPEMTLEDKMLQRFAMERKTHHEKAGAFSLNEDEELTHFGQSLSQIEKFEEPESDSEDDATGKLSGEYVKEAHFGGFLTKKASKDSGEEKSDKPKSRQEMIEEIIAQSKQRKHERQNQKEQTDDLREKLDQQWTDQLHMLVKKTNKKESQPKEDKVKPEADDYDIMVRELGFEIKAKASDRLKTEDELAREEQERLQKLEADRQLRMKGLTQEDIRQQQQNRHVSADDLDDGFDFIRPERLQLAYKDGKLLLPEGKELMPSTSDADQKPIRRKHHSEAASGSEADQSEDEDKEGHSDEENSDQSEGEGSDQSEEEEKDDDGSDLESERSSDNDSEEEQEEEEEDIDNEGSEEEVEEDREEKDKREQKTQAMEKTSISKKERKAIAEAAKTELSLYFSPESLKDLMELLEGQSYDRQLLIMNRIRKCHHPSLAEGNRKKLQNLFSILLEYFGKLANQSPVAMEMIDGLTIHLYELAQQSPGPSADTVQTVLKNKYHKFDSVCQRKGRAVYPAVDTLLLFKLVSVIFPTSDFRHSVVTPAMLFMAQILTKCPVTSGRDVACGLFVCTVFLQYVSLSKRFVPEVINYLQGLLYLAVKKESRKAVAAEVVPPFKHTGAQGNLLVLQEPDDSGSMSIEPLPLDYLSKNPVQDTDTDDFRISATHATLQLTNMFANMYKNLPAFHEIFSPISDLLSKHLLLAAYPQEVQDGRSQFLQLVTDHHSQATYPPLQYEKLKPKPLKLYEPKFDEDYNPERKMKGSRKQKEKERLLKMHKREMKGAVREIRKDAQFLARQQLQEQMDKDAERKRKVKEIMHHLSSQEGECKQIAKKKIKIM
The following text describes a protein:
Function:
Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Interaction with isoform 2 of BSG is required for its localization to the plasma membrane.
Sequence:
MPSGSHWTANSSKIITWLLEQPGKEEKRKTMAKVNRARSTSPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHTTPEQNHVCRTQKEDIKRVSPYSSLTKEWAQTCLCCCLQQEYSFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLGFARLIKRMRKTQLQFIAKESDPKLQLWTNGSVAYSVARELDQKHGEPVATAVPGYSLT
The following text describes a protein:
Function:
Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.
Subcellular Localization:
Nucleus.
Sequence:
MGESTRMMRFGWAPRRRRASAKDEGGASLGCSVQLGQARELARKGEEGCSVAAAPSPASVLLRRRRLGSPVPSSLSHCRQLLPPPSSLPHHSLAEYDRWHLLLRQMSPSIDFLIYVFSDEDLTNRAWRPAMLPQGPQANGRDGRWLNSGPHAPLYAAKPAEPKDAFAPRAIETRDGTLLPKPGPTRKPTSRFLLLAAAASASGDPRSPRRSKSESSARRRKEEEMVSGSSSSVVNVYPLANYTFGTKEPKMEKDTSVADRLARMKVNYMKEGMRTSVEAILLVQEHNHPHILLLQIGNTFCKLPGGRLKPGENEIDGLKRKLCSKLAVNSPSFPPNWQVGECVAVWWRPNFETVMYPYCPPHITKPKRYGPVISTIPQQLSRFQFNMVSS
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKLKGRDRRDKYYHLARESRYRSRAAFKLMQLNSKFSFLTSSQSVLDLCAAPGGWMQVVVKKAPVGSLVIGVDIDPIRPIAGAISLQEDITTAKCKSTIKRIIAQKGCSGFDLILHDGSPNMGGAWAMEATMQNSLVIDSVKLAAQFLLPNGTFVTKVFRSQDYTAVLYCLRQLFEKVEVEKPLASRSESAEIYVIGFKYKAPAKIDPRLLDIKHLFQGGQEPLKAVDVLRVTKQKRHRDGYEDGETVLRKVCSAADFVWSDIKSLGSVTSIMFDDPASLPMRDHPLTTEEVRTLCEDLRVLGEQDLKHLSKWRKLMRKALAPSETISNPKVVIECEREEDEDTRLVKEMEELKETELRKTKREKRVLAKRQAKDKARELLGMQSDAAEDGFADPELFSLTLIKCKRDVVVVDDDECDDGTAEVNSEADGNDLEAPENASTDMDSEEERLRRDDEIEGLLEDHDKRYMARGERKTKRSRISYLDDCKLLERGDEDGMTHSAQDSDSDKGEDQVNPLIIPLETAPSQEEVVKTWFTQDVFVEPEEQEMLDKYNSEDEMLVVGEITPISKTQTTGELLAPILSKKRMNGLLQVPSHETPNDFEIVPVPPTDSSDSSSDESGDDIDRKAEILSVAKKLILKKQREAMMDDGYNKYMFDDEGLPKWFVDEEKRHRQLIMPVTKEEIAAMRAQFKEINARPAKKVAEAKARKKRAAQRKLEKIRKKANSISDQADVSDRSKSRMIEQLYRKATPKRAEREYVVAKKGVQVKVGRGKVLVDRRMKKDARRRGMSKQGLKKGGRDRKP
The following text describes a protein:
Function:
Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic granule.
Sequence:
MATVAELKAESGQPVVPLDRQFLIHELNAFEDSKDNTIPLLYGILAHFLHGTKDDNQNTFLKGSSLPPANPNLGRQPSGRKQMEEHLRQEQARGSNAENLHTSPRVKR
The following text describes a protein:
Function:
Relieves the repression of host cell immune response genes (interferon-stimulated genes) by blocking the recruitment of host BAHD1 to these genes. May modulate interferon-mediated immune response to control bacterial colonization of the host.
Subcellular Localization:
Secreted. Host nucleus.
Sequence:
MKKLVAWFNGLSKMWKVVVIIGAVFVVIIALTTGEDEGEQTKTKKDSNKVVKTASRPKLSTKDLALIKADLAEFEARELSSEKILKDTIKEESWSDLDFANDNINQMIGTMKRYQQEILSIDAIKRSSEASADTEAFKKIFKEWSEFKIERIQVTIDLLNGKKDSEAVFKKTYPNQIIFKKVRTNKLQTALNNLKVGYELLDSQK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MFSACRRGPASISRALRAVPSTIRIPSTRPSTLSLISQKSSISALESRWLHVSAVSQLQSVATKEAAVIQENKIINRFDELTKYGLVHPNVVNEITDTMKLETMTEVQTMTINQALQGTDIIAQARTGTGKTIGFLLPTIQNILEKSPELATRQRYSRARPSDIRAIIISPTRELAEQIAVEAVKITRNTDLIVQVAVGGSSKREMLRKVQREGCHILVGTPGRLQDLLMDEYSQVSAPGLTTLVLDEADRLLDDGFSKDIENIEALLPNRKEVDRQTLLFSATVPREVMRLVKRTLKPGYQFVQTVKEGDVATHERIPQKIAATVGLENTIPALVELCKKGIEKANTEGTSPFKAIVYFNSTASVQLAGEIFKGIDSLHSVETSAIHGKLSQERRTRVTDRFRRAQSAIMFSSDVTARGMDFPNVTHVIQVSVPRDRDTYIHRVGRTGRGGKEGEGWLIMTQAEIPVARRLLSALPITPDRTLATALVDMKKDAQLPAATAEILNEVGQATKRVDREVKVDAYMAAIGGGRAGQNNRELMMSLNDMVKYGWGWEKPPLISPGMAQKLGVAKLPGMNIGHASREDDDDFGGGRGFGSSSDGGRGFGSGGGGGGGGRGFGSSGGGGGRGFGSSGGGRGFGGGDRGSSGGRGFGGNRSGGGKGFGRSDRSGGKGFGGGGSGGRGFGGSSF
The following text describes a protein:
Function:
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').
Subcellular Localization:
Nucleus.
Sequence:
MSDDKPFQCTAPGCGQRFTNEDHLAVHRHKHEMTLKFGPARTDNIIIADQTPTPTRFLKNCEEVGLFNELASPFDHDFKKAAEDDLKKLPLDLSPLATPVIRNKTEEPAAVDAHRNSPLPHPESTTNDDKDLTLQPASLPTSTIVHPASLQVPNVLLATTDANVVIQPALPSPTSSSVITQVPSTNRPIVPMSGTFPVLLQLPNGQTMPVAIPASITSSSVHIPTTIPLVRPVTVVPAVPGIPGPPSPQPPPAQTEAKLTLKATLSQQLPQVTNGDNGEIQSSAVTHTAPASPGLTPPPAAAAVLTPAPHPPKTEELSTHSLQQPATSTTETPASPAPPAQNPPTTGGRRRRTTSEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSMNGQLQNEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHISDREESCEEMSVPSSPQNEAIQHSSVSTSNGISASSTAPPSAACSAAPSNHSTEDGQPQQGAAQTQPSGS
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
METHVPCTLEEERRIVTELISEAGDNLKEGNLYFVISNRWYTSWQRSSREPTRPGPIDNHDIIDTQSDASDPQLCRRLEEGVDYVLVPQQVWKKLVEWYKGGPTIQRKLICQRFQSYSVEVYPLCLKLTDSRDKSSATIRLSKQASVGLLYELVCSARGVSKEKARIWDYFEKKKSVLLDPSSERTLEESCLQVDHDILLEVDENASSKYDMSSAGNELALVPVGPTRSDATNTTPGANGHSSSGFGEREKRGLRGLHNLGNTCFMNSTLQCLAHTPPFVDYFLKDYSDDINEDNPLGMRGELATAVGELLRKLWSSGKNAVAPRFFKTKLDRFAPQFSGYNQHDCQEVLSFLLDGLHEDLNKVKQKTYTESKDSDGRPDDEVAEEMWKYHKARNDSVIVDVCQGQYKSTLVCPDCGKFSITFDPFMYLTLPLPTSLTRSMTVSVFYGDGNRFRTPYTVTVPKDGSLGDLSNAIGAACGLKDDESLLLADVYAHKVYKYLETPLLSLSEIRDNDRIVAYRFNQMHRGPGKAKLEILHSEQKQDAEISGKLFGIPLVTYVNSERHSGSDIDAIISGLLSPLHRTHSSSGSLEDTTVGEKEFSFSVFWLDRYSSSLKPLESDFVPNPLSATRLVVKWDEKEHEKYDSSSYLNDLPEVYKATSSVAEKVSLFSCLEAFLAEEPLGPDDMWCCPACKEHRQANKKLNLWKLPEILVFHLKRFAYTRFLKSKIDTFVDFPIHDLDLSKYVKNKEGESYLYELYAISNHYGGMGGGHYTAYAKLMDENKWYEFDDSRVSPIEMRPAPCAG
The following text describes a protein:
Function:
This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
Sequence:
MSESLVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDERLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEWLREKLGFFH
The following text describes a protein:
Function:
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with euchromatic regions.
Domain:
The ANK repeats recognize and bind RELA subunit of NF-kappa-B, when RELA is monomethylated at 'Lys-310' (By similarity). They also specifically recognize and bind H3K9me1 and H3K9me2; The SET domain mediates interaction with WIZ; In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL