lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the two cytidine residues to tRNA.
Sequence:
MDHRLLSFISAPLPSLIASLARHGGFGAWFVGGCVRDALLARPSNDIDIVVGPGGEDLPRAVAARIGGSFFPLDEERGHARVVLKGEGASCDFAPLQGGTIAADLALRDFTINALAVSCGSDDLLDPLGGAADLAQRVIRACSAGAFAADPLRIVRAYRFAAHLDFEIHAATLALIPDHAPLLATVAGERIRDELFRMLDLPHAVPYVLKMSCAGVTGAIFGADDLPADTAAGALDRVESLCRDLSAFGTEAEPVRARLRQEVQPGITIRALAKLAAFLNGAGIPAGIASQRLMLGKAATRLLELLCSSARLTWPAPAAAPDPHALFTLFCHREPAGCEQLILPLAEGILPEDRCRHLAAYLTRQHIPRGGRLLLTGDDIMILLGLPPGRQVGEAIELLRAAQSTGEVRTRAEAQRYLAKKQLTTPEPLR
The following text describes a protein:
Function:
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTEVQKLTNAKAIITYLAEKFPLCFVLEGEAKPLKIGLFQDLAEALQDDERVSKTQLRQALRQYTSNWRYLYGCREGAVRVDLQGNPAGVLDAEHVAHAAQQLAEAKARFAEKRAAAKKAQQKKHPRKPANKNLKKESKLSLSAVDFSQISVGSVVKVKAGDNAKKATVVEVLKDSARVELENGLIMNVAADRLFA
The following text describes a protein:
Function:
Required for activity of the potassium/proton antiporter KhtU. Involved in protection of the cell from methylglyoxal, a toxic by-product of glycolysis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRDPDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGRTLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFLSGEGV
The following text describes a protein:
Function:
Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Replication factor C (RFC) complex has an essential but redundant activity in sister chromatid cohesion establishment. An RFC-like complex (ctf18-RFC) is formed where ctf18 replaces rfc1 in the RFC complex along with the association of dcc1 and ctf8. This complex is required for efficient establishment of chromosome cohesion during S-phase. Acts as a PCNA loader, loading PCNA onto primed templates.
Subcellular Localization:
Nucleus.
Sequence:
MSEIRLIRAINDELYLVEVQATLERKADSLHIGDLKIIKEKNSEKKKATLTVGNQYMEGVVESLKKPLAVLQKTNADPVDVYSSPSHELKCCSIIRERIRFSSRPLPTK
The following text describes a protein:
Function:
Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Secreted. Secreted, extracellular exosome. Note=Secreted by exosomes through a non-classical pathway.
Sequence:
METVVIVAIGVLATIFLASFAALVVVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKSLPNPEGFLQEQSAI
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MRRGNGNHLEGHHLQMPRGSLHLQTSRGSSPLNVESHCIFKRQEDHCIFKHQEGHHLHLQRESLQLNTERVIASLIAKKEITSFIIERSIASSNAERTIIYANAKRVIVHSNAERVIISKPPRGLLHLQPPRGTSSSIFKRAITYSNRQEDHYIFKPPRGSLHIQITERIIISNAERNIIFKCQKVIAFKPPRGSLHFQTLRGPSSSYAKRVTASSNVVRASSNDEKSITFIYQEGHSNAERAIIFICQEGYCIFKCREGHCIQVAKRAIEYPNFGYIVLTTSAGIMDHEEARRKNVGGKVLGFFY
The following text describes a protein:
Function:
May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport.
Sequence:
MEVPAPCSSSGAQESPQDTEHKARGTDTLDSANESHLLSSAANPSVKGRPSKRITRGPFVKLADCAHYHYENVNYGPIQLTLSDSRTEEAGCTEGDVLYIVQVTCQGRSWSVLRSYEDFRVLDSNLHRCIFDRRFSQLLELPPRTELPTQGQLLAPLLSRYVKGLTGIVDSNINCGPILNWMEIDNHGNRLLVNEEASINVPAIAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPREDTSWWRGKHSFQVGFFPSECVQLITDSKSPSPTGEGDVKLTITPPHGSNSPRPVCRRHGKLAGLLRSFMASRPSKQRLRQRGILRERVFGTDLGEHLLNSGEEVPRVLLCCTQFIEKYGVVDGIYRLSGVSSNIQKLRHEFDSERTPDLSRDTFLQDVHCVSSLCKLYFRELPNPLLTYRLYQPFTEAMSAVTEEDKLIRVHDLIQQLPPPHYRTLEYLMKHLSQLSSHSDRTGMHARNLAIIWAPNLLRSRDMESVGLPGADAFREVRVQSVLVEFLLCHVETLFSDTFTSIGRCGPIRPRSLLGVCPSGRLVSLQEAQARSQSQREAAEKLGTEKSSPTKAERGLENSEERKAGRGRKKSGGGTSWRTFFAIGKNSSHKKSRLGGMENRVVHQRVSDTVTLRSAKSEESLCSHTSGTGLQRSSRLRRPRSTSEGLTTRLPHFRSVESLGPSSPPHVPSPPASARPQSAWIEEDLDLSPPLPDADGLGFDPLSFRLSFSDHEEVKSPVIVRAEITSPAVAKALPRGVSLSPTAGCSPSPTHSPPERLVVDGQSQGPRGLSPPPQMLSLLLQSCQQHLSDNSVREVKGKLTGAPGQEEPHNNVSPQQSTQPPPMSLLRQIPPPPPPKDPARLMALKLAESAQRALQASTSTGTIPAKTSQRPVPINPPSSAFRRSLSMECSETTVPREGILFSDLRPPELNTNEKSIGQHRPLKLPAHNTLATSSSPADVRKPTPTGIPPTHAPRLHTRSGSLPVPPNLCPPRVRPPPYRFPEDGPRLPHQCSAPPWTEPEGLYYEIVGDPPHMAPLNTSYGLIQPPWPHGSSSQPHPGFGNWYGGSHGTNPEVVAYSRWDRGLHPQLRPYMVGAGVHYQYVRTPESGSHVLPLGKREEPIYVNLPLKVERREQHDGTNDVAALKPELPQKQHPTNPSNMGYHESARGVTHTQWQVRHPHLLRREASLSYFRPPSSHKAMWGTQPKFPEGRENPIFAYEASTGAGQRMGHVHPHCLLSEEGMLYGNLEQRGVQHRSATPVGPPGFLRAPWTVHSEGQTRSYC
The following text describes a protein:
Function:
Glycinin is the major seed storage protein of soybean. Glycinin basic peptides (GBPs), and, to a lower extent, glycinin exhibit antibacterial activity against Gram-negative and Gram-positive bacteria (e.g. L.monocytogenes, B.subtilis, E.coli and S.enteritidis) by forming pores and aggregating in transmembranes, leading to membrane permeability and, eventually, cell death.
Subcellular Localization:
Endoplasmic reticulum. Protein storage vacuole. Note=Hexamers are assembled in the endoplasmic reticulum and later sorted to the protein storage vacuoles.
Sequence:
MGKPFTLSLSSLCLLLLSSACFAISSSKLNECQLNNLNALEPDHRVESEGGLIQTWNSQHPELKCAGVTVSKLTLNRNGLHLPSYSPYPRMIIIAQGKGALGVAIPGCPETFEEPQEQSNRRGSRSQKQQLQDSHQKIRHFNEGDVLVIPPGVPYWTYNTGDEPVVAISLLDTSNFNNQLDQTPRVFYLAGNPDIEYPETMQQQQQQKSHGGRKQGQHQQEEEEEGGSVLSGFSKHFLAQSFNTNEDIAEKLQSPDDERKQIVTVEGGLSVISPKWQEQQDEDEDEDEDDEDEQIPSHPPRRPSHGKREQDEDEDEDEDKPRPSRPSQGKREQDQDQDEDEDEDEDQPRKSREWRSKKTQPRRPRQEEPRERGCETRNGVEENICTLKLHENIARPSRADFYNPKAGRISTLNSLTLPALRQFQLSAQYVVLYKNGIYSPHWNLNANSVIYVTRGQGKVRVVNCQGNAVFDGELRRGQLLVVPQNFVVAEQAGEQGFEYIVFKTHHNAVTSYLKDVFRAIPSEVLAHSYNLRQSQVSELKYEGNWGPLVNPESQQGSPRVKVA
The following text describes a protein:
Function:
3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation.
Subcellular Localization:
Nucleus.
Sequence:
MALVDYGGSSSSASEDEDCTENIQTPALITLKRPALPKAATLLGPKKPKPEEFVEDVVDDPAEHGGRMRSFKHERGNWATYVYVPATACVDQLEEFQTEAIARLEPHLELQPNESLHLSLSRTVVLQYHQIDEFSRSLQSALNSSAGFAATLQGLRIYTNEERTRTFIAAPLDAAFVEKMTAILQPIDQVMLDYRLQQFYDPASFHVSLLWCVGDQETLLNEKLTELKELLDDQDKLCLAVNEVHLKCGNKDFTYSLK
The following text describes a protein:
Function:
Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKPLLRHASRSLLAGFAPVTSFSRPIGESGRASICLRCQYRAASTTSKWSQRLFSSSTRWMEERKPSKPIPMPPPASDSKSMSESRAQDSVEERARAIMASIEDQKRLLEEQKMQAKEEAARVETETVPEQLPTADAQEQSQENSSAPGAKKDNVADNIRRVPDEHLPSHRERQRWDFSKRFSEIMDDMLPKLAVVTQKVNSYTGTDYSGVEALRREIKEQENLVKARRSAIDTAKHALDTAHAQQASAQKEVVALLERKHSWSAGDLERYMSLIRSEHVNDQAIRQAKESVIAAEAALEEARTQLEKRERAQYHEEQIWSDTIRRNSTWVTFGLMGVNIFLLLLSLAILEPWRRKRMVREIKSALEAQLEASKPALNATTASFAPTAASNSTQHQLSAIEEEIDRVTDDAESIAVEALPDSKDSIVEGSSSAPMGAILPMQAPAASTQTPISVVDPALGVASPSATIPHPQDTPAPQHASPDIPDSPRSKFESWQSKVTAVAQDVVSDRVISMRRIEYTSAILQGAAAGAIITASIIGMLRPN
The following text describes a protein:
Function:
Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tube which is important for hyphae formation. Also regulates the pheromone response of the white cell phenotype.
Subcellular Localization:
Nucleus.
Sequence:
MMSQATPSATPVRNADGQKKGKKLPLIVDVAIGNNGKQLYQVHESSKMVRKEMPRSTNFALNDDISDEGFFISQINEQRTPIRKTLGTLSPSSLNQKRIRHDVYDQGDDNSNDDNCQNDVYEQQQQQPQQQQQQQQQLHQPNMYENGNVGVISNDPVSSVGHYDNNPVSHVPTGAYSRVQDTDIWSDDVEEAFEEVLRLIPKSGLNKIKIAGRSCGRNELISDYIFAKTGKFRTRKQVSSHIQVIKNLGQKLDIIQLINDGPIFNSHEEQLESTKKFEDVFSKINLNKSLGFSDSMKRKSDSMPMHLPATKRIRRKHSGNPLNKIKFSNFFMSVNDQYGMNPIVLTIQQNGNDVKSLKLKDNANISSRFPGLSDFKSCPHIPIIHNMVKILLPQLPESYSIDDGFSSSYALKYEEPENASPTHTSIISSSRTYSLFTCVYSYGKEIVKFDEDGIQLNQDREFIPGFWKFFFSTFGDQSEGGLSAAFKGVTIKQILYESSPDSVKKEQDASKVNKSKVKLVLLWEFAKVSECKDALTTTTKLVLPPRASASSSKTTEEVFEYSEPALNSIGGTPTDTTSPNMDLNNQNLSAAATSIPGIRDTIHSASMPDINELPSSAKPQVRLQKTFQSMQHLQPHQMWQQQQQQQPSQGAYTSSVASQSLNTSLSSPYAQYGMPLPQQTIGTFVPPTSQTFGVSYTHNSQHPSANMDLMMLSSMNTGYGNITNNQDYQFGNIGYTEGFTSEF
The following text describes a protein:
Function:
Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease.
Sequence:
MEEQPECREEKRGSLHVWKSELVEVEDDVYLRHSSSLTYRL
The following text describes a protein:
Function:
GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.
Sequence:
MDGRKKKRKVLLMGKSGSGKSSMRSIIFSNYVAKDVRRLGATIDVEHSHVKFMGNLTLNLWDCGGQDAFMETYLASQRGNIFSDVAVLIYVFDIESREVERDLDTYMAIIAALREYSPHAYVFCLVHKLDLIQAEHRQRIYEERSALIRSRTEHFTIDTFGSSIWDQSLYKAWAGIVHKLIPNLSVIERFLHAFAKRIDAEEVILFERSTFLTVTSVSSEIGDLNPIYDRHERLSNIMKAFKHCAARNTHTTPASAGFVVMHTKTPQFNVFLGRFTDNTYIFIVVPPGEAAYNCAVLNTMLAREGFSKAAGAVHGDGFPLPAPDSPDESNSN
The following text describes a protein:
Function:
Involved in sperm flagellum assembly. Plays an essential role in the formation of the radial spokes in flagellum axoneme (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 5]: Created from a fragment entry and may await further characterization.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSVLTSPRGKVEVVHCRRTESQDVYCIKSLIRKFTCKLFGKLNIIYLLEKANLAVTLCNDKEEIMAQATFLDYPNWNVAKQDDWVSVFRELDSDIPCTPLNTLFMHLFVAVDEYSVGCCKEILRTVYKAVPELHFIFLIVPSYMSLGSTLITVFDQVGNIPCLTYEEDFAVHICHRHSHYPQLHVRKARVEDHDDLMPIFMRYDTILKETYGEYFLAELIEAQDEENHAVVCEVEGTAVGFMSVCSRVNMQLLHECFDLGPFHGLCFPHPDDVLESPQDLSVRRSQDAELRSSSQGSQKIVEELQEPVSPDTMENIQGNIAREAASEEALTAVQSGNVSEPEDIEKLSDISTGYAQYHHVSSRSLASLVLPEEPVHFRPIYRGASAAFCIQLFCIDEKYEARSLDFMNFVFSLFSDKNFCVISLPHLTPEFFLIQNFVKMVPFNTCTLEQDLYVFHRAGLLKSINIRFATLLDTPGVENLVSTLMLNKSILEDLDRYNKARKDPDGTLLQAFVAEVAEQIVGIAVIRNEMDIEYIRSHYNIEDFIYFSHHQREEHGHMHHFALNPIFRHYTKFFLKEILRLGFKSCLYYRVYPKSREGKFQNPYAHSLTSALHYLVPVRPRRQIVYPLEKLGINAPSKAVSKDPMSYALNHTNRKLTLEPKITVNAKIIVVGASSVGISFLETLVFCSHMKFNNLTLISTHGLPGKKLLDTEQRKFLASDHCFNDKDYALMSLCSWVNVVVGRMTGIDRAAKHVVLSTDEIVPYDHLILCTGQQYQVPCPTEADISQHLTNREVPNSSQRRYTGKVPCNHFTLNEEEDCFKALIWIRNNSITTEGNIIVYGNTIDTYTTVETLLNLGVSGSRIHLVQPPPASTITCINNYSVESAVADALGAAGVTMYRDAILAQWNDGLHPDPIYSASFTTPTKPFRLQCSMFFSFCEKNVDYETFKALNDACLVYDSRLVIDTNFHTNDIAIRAAGSLTKFSNRYYSNEWTHSNFSSKEIGFQLAAAMLHLFDPTLEPVTEPPANLDRLIPMYKGAKIQGGILPGSYHYLHIAKPAIPTPLEVQMAQPNYGLELVTGSAKNGTYFRIHINKYKMVETITCLSREPFPASNYIRLFGQHEQLLNNLCARYDENLITDLYSYFTEPWCLALFHDRFIDLRKELRQILASKEEEDLPSIEQLAHQIEDEEINPTEKPRQYLKRVFEESIYKTLVERSTLDYLHYNRYHLPMYAWPGIV
The following text describes a protein:
Function:
Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Note=Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MRKPDGKIVLLGDMNVGKTSLLQRYMERRFPDTVSTVGGAFYLKQWRSFNISIWDTAGREQFHGLGSLYCRGAAAIILTYDVNHPQSLFELEDRFLGLTETANNDCLFAIVGNKVDLTSERDTEGGEKEGPASGKVGSCVSTKVPKQVQPEDAVALYKKILKYKMLDEREMPAAEQMCFETSAKTGYNVDLLFETLFDLVVPMIMRQRAEESDQTVDIASCKTPKQTRSGCCA
The following text describes a protein:
Function:
May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle. Golgi apparatus. Secreted.
Sequence:
MWRLVPPKLGRLSRSLKLAALGSLLVLMVLHSPSLLASWQRNELTDRRFLQLNKCPACFGTSWCRRFLNGQVVFEAWGRLRLLDFLNVKNVYFAQYGEPREGGRRRVVLKRLGSQRELAQLDQSICKRATGRPRCDLLQAMPRTEFARLNGDVRLLTPEAVEGWSDLVHCPSQRLLDRLVRRYAETKDSGSFLLRNLKDSERMQLLLTLAFNPEPLVLQSFPSDEGWPFAKYLGACGRMVAVNYVGEELWSYFNAPWEKRVDLAWQLMEIAEQLTNNDFEFALYLLDVSFDNFAVGPRDGKVIIVDAENVLVADKRLIRQNKPENWDVWYESKFDDCDKEACLSFSKEILCARATVDHNYYAVCQNLLSRHATWRGTSGGLLHDPPSEIAKDGRLEALLDECANPKKRYGRFQAAKELREYLAQLSNNVR
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MPKQLIKSKNPHNQFILDHIVELKNRCLRTGQDKLAFIYQKIIQSLQKYPMPLLCEDQVQMLQGVGDKTSVMILQLIKKQYQQYEIPFHKFNEALIQDNLDVINEQEDDIDQIYSESCPPSMVYNDDTSKRKDKQFQASFIEELRKQVIKPIPEVQSKSKRQYQPGKGSKSGQVLMSLYKFQKSENKLFASKKQIKEQLRDICNTELSSWNAIETLEKHQLIQKTVLDNEIKYALTEDGIKLGQQYFTETMIQQQMTVPSERPSKIILLIDNRERFQSNNRQIIFEKLTNIYQIECRLSQLPIGDFMWICQKGDDEYICDYIIERKTIQDLAHSILDKRYQAQKHKLKHCGINNRFYLVENSSSSNLPVPRATIDKAIRNTQIKDGFFIQQTETLEDSLRWLALFTKTVKVLPNAIKFSEFMYNNSKKAESLFNLWGSMLRGIHGVGLESAKAIACVWKTPIEFYDAINQDENKSLQQLIEENSIKQRSIPSHILRQVEILFQKEHYPN
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor.
Sequence:
MSLYPWLVKRYPNTLCSVVEDHSSLDTSKPNPNGVEFDNLYIHLTDIIHTCFHPGGLPAPQSYDGIFHFVLEYIHRVFSIVRPRKLLYLALDGVAPRAKMNYQRIRRFRAAKEAARKRTGKPEGDKLDSNVITPGTEFMDLLSCALRYFVYCRMNRDPGWRGIKVILSDSTVVGDGACKIMSYIRSQRNLPGYDPNTRHCLYGVDADLIMLALATHEIHISILRPMKGINVGKKYRKTELPYSECMKGLMIDLKFELFNIWVLREYLEKELVPNVEGTDFDCLIDDFVFMCVFVRNDFLPRLPSLDVSMGGIELLLVVYQQEFAKMGYLTNAPEVNLKSTEHFLQALSSHENTILMKRSQKKEKRKKRDFQDLHNQLKIVERDIISAPNPNTEDGVELTIDEVKIHDSDMEYKHYTMKFDCESHDIDRIKRHAVLKYTEGLCWFMHYYYYQQVPSWQWFYPYHYAPLASDFCGLDKLEINFTLDQPFKALDQLLAVLPAASAQALPLFYRELMTNESSPISDFYPKDAKFDRDGKRRAWQDVSKLPFIDESRLLSEIMKVEHTLTDEEKQRNRFGRDMLFVHSSHPLAEMIKDLPSSDTSSEVQIHIRPDLSDGMNGDLCISDKPVLPTDIPSPFVDKPAVKMNCVKSVDYKYPSHAHIPKLPCGVIMPPRILRRRDWPSPPIVWHAFQSQRPTKKRKQDDKNCVLEDDGKQQNHKNGKSEAQFVVEGSQNHLTAEKSTNHTEAQQQQAGMSDGMCRDHKQVKETEDEKLIDVAFTAGDGEPKRKHKKKKQKQLDAQQEVQADGHEEGGDAPQGINNMVNSVEDPTARTQSSNNQQAPHVALKLTKRRRAKTEMVLINGGGGENKMESPAAAEAVGGENSTNKMDGVGDGPKDLVVGQMKDYFQVSEEKANKKTRKKVKNENDESKASDVSTEQEKESSKRRKKHKSKSKNVEIPGNSPRAEEQEATEKKEAVTESEPTQEAAE
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGVSPDFVAALGLLANFTGISTTLSPVPTFIRVVKNRSTEKFSCFPYIATLLSSLVWLIYGLVTPGSMAVVTINVFSVTVQGTYCAIFLYYASSAEVLATTRKQLIFVALAAAATAVLAFGVFTDDRRSEVVGSFGDLLSIISVAAPLSVLGLVIRTKSVEYLPLPLCVNNLLNSCAWGTFAIFKDDVYIGAIRSPLTAQNLSQAPNVPGVILGLIQVGLHCIYGAPFSRAKLQQFPPARRNSVSSRAAHKSEKTSLLSPDPEDQLPVSPKMHSPLLGGLERVNSSVLDPGEMERPGIDLSVVTEASPVDHYPDGKRVSYISPADGKYPLLEANGEATHGNRRPSASQQYPVMEKAHLMPEAGHVTPTRGQTGQTAQLRRPSISMQYPLVESAHQMGAGSASRRQSKRLQEEDPEAALLRRTSGGVDNLFVAQPGPHTPVADGRSDSTSWEALVQGQVLIENMSFEPKRDA
The following text describes a protein:
Function:
Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASHSSTLFTSPSSFILFSSHRLKSSPNYFTYHFPRSVKRPHFDLRCSVSIEKEVPETERPFTFLRVSDGDQTQSSSYSVRARFEKMIRTAQDKVCEAIEAVEEGPKFKEDVWSRPGGGGGISRILQDGNVWEKAGVNVSVIYGVMPPEAYRAAKAATSEQKPGPIPFFAAGTSSVLHPQNPFAPTLHFNYRYFETDAPKDVPGAPRQWWFGGGTDFTPAYIFEEDVKHFHSV
The following text describes a protein:
Function:
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Subcellular Localization:
Cytoplasm. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Sequence:
MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MCRGGRMSAATKTWRCWHRRGNTTQKRYAVCSALAASALPALVMSKGHRVEEVPELPLVVEDKVEGYKKTKEVVLLLKKLKAWNDIKKVYASQGMRAGKGKMRNCRRIQRRGPGIIYNEDNGIITAFRNIPGITLLNVSKLNPCAKTMRRNTILRQARNPKLRVDKAAAAAAALEAKSDEKVAVAGKRSLWWVRVREKKGKKAAVGVKKQKKPLVGKKAAATKTPAPEKNPAEKKPTPEEKQPAA
The following text describes a protein:
Function:
Component of the NF-Y/HAP transcription factor complex (By similarity). The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MESEKVVVDELPLAIVRRVVKKKLSECSPDYDVSIHKEALLAFSESARIFIHYLSATANDFCKDARRQTMKADDVFKALEEMDFSEFLEPLKSSLEDFKKKNAGKKAGAAAASYPAGGAALKSSSGTASKPKETKKRKQEEPSTQKGARKSKIDEETKRNDEETENDNTEEENGNDEEDENGNDEEDENDDENTEENGNDEENDDENTEENGNDEENEKEDEENSMEENGNESEESGNEDHSMEENGSGVGEDNENEDGSVSGSGEEVESDEEDE
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MTSTATLRRLQSSLRRCLLLAKRASSKNVSLRQASQNSKDQEFKPGMRVLNVAEKNDAAKNLSEIMSRGSYRRRDGLSVYNKIYEFDYNLFNTNCKMVMTSVSGHLLTLEFVSDYRKWHSCSPVELFHAPVIMSCGDKNYEKIKETLEKEIRYCDALVIWTDCDREGENIGFQIISVCRKVKPRVRVYRARFSEITPQAVARACQNLADPDPKLNAAVEVRRELDLRIGAAFTRLQTLRLKREFPQQLHDRLVSYGSCQFPTLGFVVERYRQILNFVPEPFWKIHLTHKKDDILADFSWKRHRLFDYQLCFLLYQRCLQGEVSVVVEMKCKPKSKWRPQPMDTVVSGEAPFYLGASSLSNCWRVLRNPGTSDQLPGSRTTCGMIRRLRHLTRNVLTSALSSAPADFARRLLADGLTPRQGTKSDQAHPPIHPIKHAASLEFVATGLIIFARNYLDVYPYDKWSAKEIPNYEMNETFVPDQLKLVDGETSPPPLLKEADLIALMEKHGIGTDATHADHIETVKNRLYVALTGDGYLVPGELGMGLVEGYDSMGLEMSKPRLRAELEADLKKICDGTKNPKDVLRRQIELYEDVFSNSERQIKKLGESLKKYLGTGQRLAPPANGPRSNRTDQSRPGGGGDSTNAGASNRRGGRRCGLCNQEGHNRRNCPNR
The following text describes a protein:
Function:
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
Sequence:
MRGEQGAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADAARQ
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MASTGMQIFGFVLALLGIMGATLATLLPNWKVSADVGSNIITAISQMQGLWMDCTWYSTGMFSCTLKYSVLSLPAYLQTARTTMVLCCVLAAMGLCLASLGLKCTRWGGGRRSKRHAAIASGGCFVAAGFLCLVPASWFTKEVITSFLDSSVPESNKFEPGGAVYVAFVSAGFLFVGGSIFCMSCSGKRHGPQDLILLPPPDKLLLQQQQQQLLQQQQELQHQYCSLSPLDNKTGYSLQDYV
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MSGTEEAPAVDPAWIPLYKPVSEAEPTPIDIEASRKLVEFLDSAGAIADAEAMKHRQAVFETVSKIVDQFIEKVRVNKKMEPPEGEVYKGKLFYSGSYKLGVCSPKSDIDCVILAPQFVQKEEFFSIFYELLAADTKVKGLIKVEEAYVPIIKLTYDDIEFDISFAALGLNNITDDIDLSPDSVLENLSKLSVRALNSLRVNNMVIKLVPNLDNFKTLLKFVRYWAFKRGLYGNVYGYFGGVNLAILSAFVCQRYPTASPAMLALYFFSEISQWTWPTPIYINRPNYGELLSWDPTTESDHNDVMPIITPAYPSTNSQRSATTSSRNRIIQEMVKALQIMPNIITGDLPWSAVCEDHEFFESYKNYIEIDIRAEGLADYNWWKGTVISKVKRLITSLEAIERVKCAPIFPSSFDRENNNKYQGSIFIGLETEKTKDDEGKKVNPSAAIKKYLEEIYKLTNRPLSTKIENPQVINRKKIPDFCFPNGRKKKPSKKHLKKKSSSSEKKGK