lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.
Subcellular Localization:
Host nucleus. Host cytoplasm.
Sequence:
MWGVSSLDYDDDEELTRLLAVWDDEPLSLFLMNTFLLHQEGFRNLPFTVLRLSYAYRIFAKMLRAHGTPVAEDFMTRVAALARDEGLRDILGQRHAAEASRAEIAEALERVAERCDDRHGGSDDYVWLSRLLDLAPNYRQVELFQLLEKESRGQSRNSVWHLLRMDTVSATKFYEAFVSGCLPGAAAADGSGGGGSHYTGSRAGVSPGIQFGIKHEGLVKTLVECYVMHGREPVRDGLGLLIDPTSGLLGASMDLCFGVLKQGSGRTLLVEPCARVYEIKCRYKYLRKKEDPFVQNVLRRHDAAAVASLLQSHPVPGVEFRGERETPSAREFLLSHDAALFRATLKRARPLKPPEPLREYLADLLYLNKAECSEVIVFDAKHLNDDNSDGDATITINASLGLAAGDAAGGGADHHLRGSPGDSPPPIPFEDENTPELLGRLNVYEVARFSLPAFVNPRHQYYFQMLIQQYVLSQYYIKKHPDPERIDFRDLPTVYLVSAIFREREESELGCELLAGGRVFHCDHIPLLLIVTPVVFDPQFTRHAVSTVLDRWSRDLSRKTNLPIWVPNSANEYVVSSVPRPVSP
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGRPITRIQSPLKPLRVATDGSIWLRSSQVSLAAAATRGRDDEAGRAGGDYSGSSRSRGMAAKAISSPVPVEWYPTLAVLMVSVGLMFTASFFIYEATSSRRSRSLAKEIATAAVASVFLGFGSLFVLLASGVYV
The following text describes a protein:
Function:
Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQNTKLYSLTLIALGAAIIAVLSPLAIPIGIVPVTLQTLAVGLVATVLKARETFFAILLYLLLGFIGIPVFTGGTSGIAVLFGPTGGFLLAFLVMGTLISWGLHQIKYKTIPAFIINIVGHLLMLVIGTLWLKFFTQVDWSLALKLGFTPFVFVEIIKAILVTIFGLALIRALSHTNKYFTN
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAFTSSQLCSLLTKFTALNGLNTYYFDTKTNAFRVSSKLKIYCAIHHALCVLALAHMSYSTASNLRVSVTVLTIGGTMACCVKSCWEKAQGIRNLARGLVTMEQKYFAGRPSGLLLKCRYYIKITFGSITLLRIHLIQPIYMRRLLPSQFYLNVGAYWLLYNMLLAAVLGFYFLLWEMCRIQKLINDQMTLILARSGQRNRLKKMQHCLRLYSKLLLLCDQFNSQLGHVAIWVLACKSWCQITFGYEIFQMVAAPKSIDLTMSMRVFVIFTYIFDAMNLFLGTDISELFSTFRADSQRILRETSRLDRLLSMFALKLALHPKRVVLLNVFTFDRKLTLTLLAKSTLYTICCLQNDYNKLKA
The following text describes a protein:
Function:
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.
Sequence:
MLPKLKISAFLLKRLERTKQQCSGCLFGVFYGEGTLLLLSFNIESSLGQLNYEQIQHRFPAELDLCGLVKFGGCTDGEAHLNEVIKSVDITDNPILLQCELGTLVGLRASFFVHGKLEEVPYEVMEAHQLYNDFCFTRLQCGFFLQTAATPESVAREMHVLRKRVADGNLVFNVPQTKIFINNYGPLDKQFSGDSQIQDLIDVIPTPGHEKETASVDKKKLKGQNTPVKRLAPTGCDYEVIPIDVMRSRSRDPVSGEPPHPALSIAVTNEEQIRVQVPLEIEAMAILCRKTKLQRLYDVLIESICRGLRLFELSLIEHLTESGSGKLLVPASYHFYPQEFGHFVSCAYLEGLSDDTPSMLMRRKRLHRQFALPISRPYFRRANQMLFLGETEDAPWTPLLNTHIGLRPSGVVDGKEYLVNGNYHYYHYLQQQVQDKGWGCAYRSLQTICSWFVLQGYTNAPIPTHLEVQEYLHKINDKPAAFVGSSQWIGSTEISMCLQGFLNVDSKILHVASGAELATIASELAMHFQTQGTPVMIGGGVLAHTIIGVDYCVQTGQVKFLILDPHYTGADDLATIQIKGWCGWKGMDFWAKGSYYNLCMPQRPILY
The following text describes a protein:
Function:
Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P) but displaying a 20-fold higher rate of hydrolysis of D-I-1-P than of the L isomer, 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate, fructose-6-phosphate, 5'-AMP and NAD(+). May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.
Sequence:
MDRLDFSIKLLRKVGHLLMIHWGRVDNVEKKTGFKDIVTEIDREAQRMIVDEIRKFFPDENIMAEEGIFEKGDRLWIIDPIDGTINFVHGLPNFSISLAYVENGEVKLGVVHAPALNETLYAEEGSGAFFNGERIRVSENASLEECVGSTGSYVDFTGKFIERMEKRTRRIRILGSAALNAAYVGAGRVDFFVTWRINPWDIAAGLIIVKEAGGMVTDFSGKEANAFSKNFIFSNGLIHDEVVKVVNEVVEEIGGK
The following text describes a protein:
Function:
Agroclavine dehydrogenase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde. Agroclavine dehydrogenase easG then mediates the conversion of chanoclavine-I aldehyde to agroclavine via a non-enzymatic adduct reaction: the substrate is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione. The presence of easA is not required to complete this reaction. Further conversion of agroclavine to paspalic acid is a two-step process involving oxidation of agroclavine to elymoclavine and of elymoclavine to paspalic acid, the second step being performed by the elymoclavine oxidase cloA. Paspalic acid is then further converted to D-lysergic acid. Ergopeptines are assembled from D-lysergic acid and three different amino acids by the D-lysergyl-peptide-synthetases composed each of a monomudular and a trimodular nonribosomal peptide synthetase subunit. LpsB and lpsC encode the monomodular subunits responsible for D-lysergic acid activation and incorporation into the ergopeptine backbone. LpsA1 and A2 subunits encode the trimodular nonribosomal peptide synthetase assembling the tripeptide portion of ergopeptines. LpsA1 is responsible for formation of the major ergopeptine, ergotamine, and lpsA2 for alpha-ergocryptine, the minor ergopeptine of the total alkaloid mixture elaborated by C.purpurea. D-lysergyl-tripeptides are assembled by the nonribosomal peptide synthetases and released as N-(D-lysergyl-aminoacyl)-lactams. Cyclolization of the D-lysergyl-tripeptides is performed by the Fe(2+)/2-ketoglutarate-dependent dioxygenase easH which introduces a hydroxyl group into N-(D-lysergyl-aminoacyl)-lactam at alpha-C of the aminoacyl residue followed by spontaneous condensation with the terminal lactam carbonyl group.
Sequence:
MTVLLTGGTGRTAKHIAGIFRQTNVPFLVASRSSSAGTAENHRKFDWLDEETFPNALSVDQGMKPISVVWLCPPPLYDLATPVIKFIDFAVSQNVKKFVLLSASVIQKGGPAMGKIHGHLDSIKDVTYTVLRPTWFMENFSTKGEIQCEAIRRDSTVYSATENGKIPFISVVDIARVAACALTAETLKNSDHILQGPDLLTYDEVAQALTGVLGRKITHTKMTEGELAEKLMEEGVTPEEAYMHAAMDSMIKSGSEERVVSDEVKEWTGVKPRGFINFALSEKAAWRARK
The following text describes a protein:
Function:
Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTKEEGRTYFESLCEEEQSLQESQTHLLNILDILSVLADPRSSDDLLTESLKKLPDLHRELINSSIRLRYDKYQTREAQLLEDTKTGRDVAAGVQNPKSISEYYSTFEHLNRDTLRYINLLKRLSVDLAKQVEVSDPSVTVYEMDKWVPSEKLQGILEQYCAPDTDIRGVDAQIKNYLDQIKMARAKFGLENKYSLKERLSTLTKELNHWRKEWDDIEMLMFGDDAHSMKKMIQKIDSLKSEINAPSESYPVDKEGDIVLE
The following text describes a protein:
Function:
Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm.
Sequence:
MWGSALPSVRVDSWSVRSVGFPKALVEMDSRIPYDDYPVVFLPAYENPPAWIPPHERVYHPDYNNELTQFLPRIVTLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFSARNTDNPNPFRPALQYLINTANSNLPRTRSNHRKIQSVSSLDSDGEAFDRMSSRNATTSSELQPSIPLINISRSPSPYRPRAASDPTSESDEEYENWGTSSRRPILSGAEPKYTGWRYALYSGGLGHFLFNTTMGWQFYIGFLVFWLGGCGIGLTVMNRIILWTGVYKFPWPVTTTFIELLMTHGFLWLSAFLTRLASPVCITAGVSSAVAPSTPLQTSNSPGFRGGGKKQGLLSTLGRLSSASSGGIAGGGLFEFDMAVARQVLPLAIIFVVKVILSNISFAYAQLPIYVMARIGIVPFSLLFTALLGQQQHSASTISSALIATLFLLLGTMKAGIRAPWESIVAGVFSSIFVALYPVQIQRTYKVLVAQLVPQGDLIGGFSSSNGSSDFSGSREENRAYWRLLHYTSLLSILIFIPILLLSGELGSVYRNCYFMDVFFHWLMVLCGGTGSWAVFWCTIALTRASSPLTTSFLFVPRAAFLLPIMAGFKMPASSWIGFASKGCPHHKECVIIQL
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus.
Sequence:
MAALAEKILLEAAEKDALYKPTYVEKDLDLAFDLGTLLATDPNPLDAQKLRSESREEYLTELARGNTQLLINKLFELPTERVEDVIVAKLPDGTTRLPREKPVTEAHPHSLMFCWYKSSIKVVVKWGNGTNLSENARGPHLRQILGEFSKSRFKGPHSLPPPTPVYSEACPGCQRAQQASRRRKREWGSGFILCLPKNLFPPTENLSKDQVATAVTLAKSSTASHGKFAGTLKEEKNVRVRKAKRKASLLFSLLQDEKASQLKVLDEMARKKPKLDINQAVNHFIHDEEVK
The following text describes a protein:
Function:
Required for the transposition of the insertion element.
Sequence:
MDAAQVIEPAHAGQDVDEAAVAARELSGAERALVGDLVRQARAEGVALTGPDGLLKALTKTVLEAALQEEMTEHLGYDRHAAAGRGSGNSRNGSRNKKVITDACGQVEIAVPRDRNGTFEPVIVGKRKRRVTDVDRVVLSLYAKGLTTGEIAAHFADVYGVSVSKDTISRITDRVIEEMQAWWSRPLEKVYAAVFIDAIMVKIRDGQVRNRPVYAAIGVDLDGHKDILGMWAGEGDGESAKFWLAVLTDLRNRGVKDIFFLVCDGLKGLPDSVSAAFPLATVQTCIIHLIRNTFRYASRKYWDKISVDLKPIYTAASAAEARLRYEEFAEKWGKPYPAITRLWDSAWEEFIPFLDYDVEIRRVPCSTNAIESLNARYRRAVRARGHFPNEQSALKTLYLVTRSLDPKGTGQTKWAVRWKPALNALAITFADRMPAAEER
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFLCDLVFGFCDGRYSESLHAFLCFGGMYHFVSGGNLALQIVIVGALRTAFIFAPFVAFQTYGYYNMCVERSPDEIRPWCKARIPLLHNYIQSHYWGVGFLRYFQLKQLLNFLLASPILSLALRSELSIMLKHSNLRRSKNVSKGDIANVPMESEPAAIWPGYLSASVLPFVLHLGFMVCTAFFVMRVQVSTRFLSASPPLYWFASYIMANLYWFASYIMANPAKYFRWGYVIWAYSMAYIFLGSLLFSNFYPFT
The following text describes a protein:
Function:
Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters or lactones using NADPH and/or NADH as an electron donor. Preferentially converts short-chain aliphatic ketones like 2-decanone, 3-decanone and 4-decanone. Some acyclic ketones are converted not only to the alkylacetates, but also methyl- and ethylesters are obtained, indicating insertion of oxygen on both sides of the keto group.
Sequence:
MSSHTALPVEPLDVLIMGAGVSGIGAAAYLRRNQPNKTFAILESRERMGGTWDLFRYPGIRSDSDLYTFGFDFKPWTKAKSLADAADILEYLSEAIDEHQLAPFIQYQQKVISANWQSDKGLWSVRVEDGRTAQIRTVECRWLFSAGGYYRYDQGFSPRFEGSEQFKGQIIHPQHWPEDLDYTGKRVVVIGSGATAVTLIPAMADKVASITMLQRTPSYIINQPANDGVAAFLRKVLPAQTAYSLTRYKNAKITLAFWGFCQRFPKLSKKLLLWLTRKELPKDYPVDVHFNPPYNPWDQRLCSVPEGDLFKAISAGNADIVTDHIERFTEHGVLLKSGKMLKADIIVTATGLNVQLFGGITLHKDGKPVVLSETLAYKGMMLSGVPNFAFAVGYTNSSWTLKVCLLCDHFCRLLGLMEREGYNVCEPKAPEGVETRPLLDFGAGYVQRALDSMPRQGPREPWVMSMDYFRDVKLLRRGAVTDKCLKFTAVPNAPLHADVQLQQQGSRR
The following text describes a protein:
Function:
Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MTQTPQQRRANEKFAKHEASKRGKPKTTTTKHNTKPSLSTGWVVLLAFVVCGGLVFELLRIVPQLWSAIASVFNRLLA
The following text describes a protein:
Function:
Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.
Sequence:
MKSTSDLFNEIIPLGRLIYMVNQKKDRLLNNYLSPLDITATQFKVLCSIRCAGCITPVELKKVLSVDLGALTRMLDRLLCKGWIERLPNPNDKRGVLVKLTPDGAAICEQCHQRPGQDLHQELTKNLTADEVATLEYLLKKILP
The following text describes a protein:
Function:
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MWRLPGVRAALRGVRTAVERRSRTEAASETSVGAMERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRALSRIATNALKGHAKVAAAKKSRKNRPNAGSGVACAGPGPEPAAACEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVCPKLGVEFGDPTGSLFRWYKETKPRAAEPEGGGPSSSSPSSPSPGWTETGVDERVYTPSNADIGLRLKLHCTPGNGQRFGPSRELESVCPVEAGPGTCTFDHRHLYTKKVTDDALIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVDRCVFTDSLMPALEAFGLEGVFRIKQHEGLATFYRKSKFSLLSQHDIAFHEALQSDPLHKELLEKLALYPSAQERVLQRSSVVQVSVLQSTKDSSKKICVANTHLYWHPKGGYIRLIQMAVALAHIRHVSCDLYPGIPVIFCGDFNSTPSTGMYHFVINGSIAEDHEDWTSNGEEERCNMSLSHFFKLKSACGEPAYTNYVGGFHGCLDYIFIDLHALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKWK
The following text describes a protein:
Function:
Transcriptional repressor which negatively regulates transcription of FYV5 by binding to the promoter on the sense strand.
Miscellaneous:
MISCELLANEOUS: Encoded by the antisense strand of the FYV5 gene.
Subcellular Localization:
Nucleus.
Sequence:
MGKCSMKKKGVGKNVGVGKKVQKKRSISTAERKRTKLQVEKLNKSSETMIPTLLREASTQEPAKLKAETTLKAEELIKDQEKDSKVREQIRTEKSKTNDSMLKQIEMISGFSL
The following text describes a protein:
Function:
May control the production of phosphatidylinositol 4-phosphate (PI4P).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDNDYTTSTTTSRRPRFWGFFFILFPLVSFLMWTIGLIVLLGLWSTQDKWHTPSEPDPVYLSDMGAYTKGFFIPMCVITGVFYFLTFIMIRLARQWGWIYPTGRKVETYLGWFAALTGAAAASCLISLSIRDDVHHDNVHWKFTAAFVVLAFVSAASNIFEWLSATRYYPQSSLLRVSFIFKFVIIVVGIICAIAFGGLHHNYRGRSARFEWVVCFLWSIYICLLCLDLAPALFYDSLASAPDLEKGAYATSVPESYVAPMEPPAAVLPDGEERYATPDLVPDTTAQYPYASATEPGVSNIPETRPERPVVYNMDVSQTTTTTRPVLA
The following text describes a protein:
Function:
Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MRPLPLPLRSLPRSATLGPRRTASADRYLAIHHFFTRHAASPISRHIPRRLSSSPAKRCLDCPTSQPPPNPDNPTPYPPQGHAQEYAPFIQRLIRQSKAIAPNSPHRPSKEELLEAANGWWQRMRIRLKWFTIRGWRRFNTDDMSAFASWFLVGNTVWILVGTTTFVSAIFALANSLSLQEYLARWLSDYMTYNTGVTVIFESAIVPKWGSSLITFKNVYVSCRPDEGPSSAPVEGGKKHVKAATAKPPSPIPFLSSAISPETYLAAPPAPPEDNYTMYDVNIDQLEVSLSFMRWLDGKGLVKDVRIKGVRGVVDRRSVWWDLSKPLDPADFRHATQKGDFEFESFHVEDALVTVYQPGLRPYNVSIFNMIVGPFRKRWLFYDLMSAEGITGQFDNCLFSLHMPQKLGKSVEKEGGMVKRMARFRIDGLPIEHVQYASGYTPPMSWLTSGKLDAVLDIKFPHHPDDQVDLQALFAEIGRNVATISHGVHPDDPDEDKLKGAIESAETSLVGVIPGQHRLARPPLRAPKKGDYGKEEEERKVVVDIDLRFRDLKAAVPLYTTDLTVTNNALIRPIVAFINANKTLVPIHCQVDADLGNFEGSWTLFETGLMTSISDQIYEAMAFHVSSEAANSRRLRQVSVWGIQRSAEVLIDMLRGVVDPVGAQFATV
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKPTHLKLQAKLDIVKRKMGVEDGKLNPFDHIKVNTRRQVLNKGEHKYRHTCAKPITEAIKKPLGSAGNNAHVIAEINDERIVPKQGEKGYSYQRSELIRHSINQTPQKFDFPDNTRPDERIFYEREMRQRARDVYAEVRAKAKAYREEHKRINRDVSEAVQQLDRAYGTVSRLLPKETRLESQSIVAEFQPLDGVRVHASRGATNLADAVRACAETLEKMDRDRSTAPVMRPKLDHQQSTNITSNDPECLNGDFNLGDNFSSDTPEESDTQSGTEGNEHSEEDDTREHQLPHFLCREVQPTYFEKLSFSLPVPSTMDEFQAMLDSVQSIEEILVLDRLIKSNSTLLERSNRPEMERLGSFCTTRFMYLIYDAPELDPVRIDAQARGLRHITSEIPHYMMSAYQKLILTYHKAVQAVNFMRISLHNQEALKSKCSNKKKRIEGLDTVLFSTASIASQKTEACDEQPKGFLSLHGRAIFGGVMLSNLMAIVFPQGTWYTLSPDEFALTNMRVFEEQPLYTAMFLANDAPIQGLCLRLEQILLTTEDALINMNSCMLCTIYQETLFLQALVLTTLMLSNATQLHIPSVSRGLACILRVYSKLFAHSVAITDTPKKVFQSITAPYIVLSVPTEHKIELLPSLFQDDLTFTLGNILAGFSTVLNACFLQLKIAKKYDLSSQYSLLLPICKELQSHLVPAESYSTPGTQFSIQWSLNLLVETLSSERKEQSLSWIDDRLPEIKANEPMYMVDFCPGKSMDPNKARERARVEEKRIKKQKRDEERSARREIRRKAALRTEQKLKLKTGRERAANKVQHMLEVDQHSYKDLDAARARLLKKRGASGRAGGR
The following text describes a protein:
Function:
Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.
Sequence:
MANTFNPEEDFPEVYKVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFLALEMMPTNCRIMLVKFSSERDIYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGAGSLLALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIRNEYDRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQWKLDMVSLIEIVSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMRLPQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMAHANKYKTDAKLFTMDY
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MFASSSVTQFYFGNTIQIIRDFRSMIRVKSTGFVSVQFKELAQAYEVLSEAEKREIYDLYGEDALKEGMGGGGGGHDPFDIFSSFFGGGGGHPFGGGRSRGKRQRRGEDVVHPLKVSLEDLYLETTKKLSLSRKALCLKCNGEDDIHKSIKYNVWSSTSNGNKKLNAAYNEAAGDKSSCPVFLIFSVNTSGQFVGLAEMMAECWQQDKWVGCFPVKCHIVKDILNSSLRHITLENDENKPVTNSRDTQEVKIEQGVKQSFTASDKKATPKDKSKETSVIAEVAEEISQNSVAEVASTC
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAFYDTWPKVDPIIVLVVLCLIVLVDRIWEMILTKRQQLVCLNAIMVPEELRGIIPPEIYHRARIYELHKTELQIWKYLIDLIITLCELILGFYPFLWSLSAKTLQKITSQEIWITLIFVFYLTIYICIRFLPVLIYDKCLLELRYGMSGKFPWYLYCCIGAMSILLSQLVLFPLAAAIVFSVKFIGYYFFLWFWLFWATFTLLLVFFLPYCCIPCIGRQVVLPEGTALYMEVKRVCDVVGFPMKRVFIIKTRTMQYSNAYFYGSCCLKRIVIFDTLLLNKGKEPNEIHPYEVGRGLTNIQVAGVVCHELGHWKHGHFYKATIIMKIHFFITMGLFGLFFHSPQLYMAVGFEPGVMPIIVGFIIVLKFALTPYLTLANVLMLWNLRRFEYAADKFAHRMGYSIQLRMALVKIYADHMSFPVYDQCYARWHHTHPTILQRLAYQQKLDVKAMNAGTY
The following text describes a protein:
Function:
Required for biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
TSHGKGRAWTRLALMQKKLADYIRIIVENKAAMAPARLPRGFPCIISGTVYHTYHPVSASDEAMQEYLTSSLTTIEGPYPGCGTLLSGDFNRLTISHLTAQFKLKQLVKVPTRGERTLDLIITNMSQSYDKDQVKTFPPFGLSDQLVVLMQSTKRSVRNTTSCRTPSVIPGQVADRNWVDISTLSIGPFLIPFMAVSSIRLHINDPPWIIAEFNHLIKLRQKAFAEGDHEQFRRLRNVVNRELHTMDELKLTGNCLKGSRPILSFDEHFDKTPHNVILKEMFIQIFGTPLNHPKSKPFVDRVMTFSIQDNRIWVRNFQ
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MSSSRVSLESYLIPLDEIKRATENFSQERCIGHGGFGAVYKGELSARWQNRTAAVKRLGPDSYQGEREFRNELQMISRFHHENIIPFIGYCDEGVEMIIVYEFAKNGSLDYHLQNPGRMRCITWIQRLKICLGAARGLDYLHSGLGEHNRVIHRDVKSANILLDANLVAKVCDFGLSKLGPRNQPDTQLYTKVAGTQFYLDPTYHESRILRKESDVYSFGVVLFEILSGMLVYGERSFGDEQQFLMNNVRRYHQNEPDKLIDPYIRDQINCGSFDTFKEIAYQCISLNLTERPMLDTVIKKIEEALFIQMSEHSASNPADHFTIESLLHKLNSTRPYDQWIATGEISRLTKASPENRIAFAQAGAIPLLTDFLRAPDSRTQENAVTALLNLSIFEDNKGSIVTSGAVTGIVHVLKEGSMVARENSAAALFSLSVIHEKDFIIASAGAISPLVLLLSEGTERGKRMATNALFNLCINEGNKKRAVRAGVVPMLMELLMEPQGVLKDKAIAILAVLSIQIEGRLAIGIAAALPILVEIIEMGSPRNKQNAVVVLVELCLEDRNYLVEAQELGAIEKMMNLLEHGTDRGKVKAIELLEKIKKLEYLR
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRLAPTVRLLQAPLRGWAVPKAHITAKPAKTPTSPKEQAIGLSVTFLSFLLPAGWVLYHLDNYKKSSAA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTTKLGTTNPAILSSGKTYQCSLYGELPHTGLGKLLERLVGLCGETKHLGLARFCEHQIAFVPAVQTPFGPPRNDDILLRLHSNVLDAESNFIHFLDREWTLLHLSPAEPPKAGQKLANHRAIHHTRITGDVIKYIEMLGYKFEFEVVRRGFTFQFGQVRIDIFRLYQIQDQFRVSSAIPVVSNSTTWIVQVTSPILGQEHVVHMSDNLFQFAAHLSG
The following text describes a protein:
Function:
Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNSLHSSCCNTSAEFFNKSWNQEFAYQILSVVDTAILPSMIGIICSTGLAGNILIVFTIIRSRKKTIPDIYMCNLAVADLVHIIGMPFLIHQWAQGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYLALVQPFRLTSWRTRYRAIRINLGLWAASFILAWPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYVLILCYTWEMYQQNKDARCYNPSVPRQRVMKLTKMVLVLVAVFILSAAPYHVVQLVNLQMGQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFRKRLPQVQRRVTEKISQMENTLKPSF