lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Regulator of both plant defense and flowering time. Involved in pollen tube growth.
Miscellaneous:
MISCELLANEOUS: Named seth after the brother and murderer of the Egyptian fertility god Osiris.
Subcellular Localization:
Nucleus.
Sequence:
METQPQQPPPPPVAEKLNPKLEKELNLESLKTRAVSLAKAIARILEDFDAYGRTNTTPKWQDILGQYSMVNLELFNIVEEVKRVSNAFVVLPKNVNAMNAAILPVMLSSKLLPEMETDDNAKREQLLQGVQSLPIPMQIERLKARMDMIAAACENAERVLADTRKAYGFGTRQGPSMLPTMDKGQAAKIQEQEKMLRDAVNDGKGTQLPPDQRQITTALPPHLADVLIINDAGKIALPGQSNNINNQGMMQVSGTQFVGRSAASPSGPNFDNTTSPLPYSNSPRATGMVNVPSPQHQIQQQQFQQQQQRSKLMQLPQHQQQQLLAQQQQQLRQSSMQGLGQSQIPALHDMHGQAQQKFQTSHGQHQMPYSQPMGAHQQFQARQLSGGHIQHSMSQGQLNPAMNRHLNQFSGGANSALFTSAQGSPSSQMIPNMSSMQSQTLVPRMQQFGVSGTNPQRSHSSQMLGDQMFNTSGMMQTQQTQIQQSQQQQQQQQQGGYGNMQTNQQSLQPNNMMQNAQQRHQNPQ
The following text describes a protein:
Function:
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKALRNYLDKIKPNFEEGGKFHAFQSVFDGFETFLFVPSKTAKTGTHIHDAIDSKRIMSIVVISLVPALLFGMYNVGYQHFTHTGATGSFIEMFIYGFLAVLPKIIVSYVVGLGIEFVVAQWKKEEIQEGFLVSGILIPMIVPVDCPLWILAVATAFSVIFAKEVFGGTGMNVFNVALITRAFLFFAYPTKMSGDAVWVSGDTIFGMGQAVDGLTVATPLGQAATSGTVPAFNMDMITGLIPGSIGETSVIAILIGAVILLWTGVASWKTMLSVFVGGAFMAWVFNAIGMENNTMAQMPWYEHLVLGGFCFGAVFMATDPVTSARTERGKYIFGFLIGVMAIVIRVLNPGYPEGMMLAILLMNIFAPLIDYCVVQSNISRREKRAVKSNQ
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVINSDDTNVDANQILAEIPRFCYRNNFQAIENSTLSCDSGWGCCFRSSQGLVCQYILRLHKNFPDLYNSTFGIDKNPLDLFLDIPEAPFGIQNIVTHANSLGLPIGNWAKPSIIASAYKSIFQSLHLNCIVPQDSTFIYEELESTNYPVLILIPGLFGLEKIEKPYISFIFLSLCMNSSLGFVSGHNDSAFYFIGFDSDYFYYFDPHVTKQALTGPPYDSLFELKLKSMKIENINPSVLLGFYCDDSIQELIMQLMGCIQSPIAVIEKSKLDDILQDVIEFE
The following text describes a protein:
Function:
Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth. May play a role during myoblast fusion.
Subcellular Localization:
Cell membrane, sarcolemma; Single-pass type IV membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein.
Sequence:
MPSALAIFTCRPNSHPFQERHVYLDEPVKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEIMSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAVTQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSIRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGLAEKKELQHKIDEMEEREQELQAKIEALQADNDFTNERLTALQVRLEHLQEKTLKEHNSLEHFLSKSGGDCTFIHQFIECQNKIIDEGHLTKVEETKLLKENQARVKESDLSDTLSPSKEKSSDDTTDAQMDDQDLNEPIAKVALLKDELQGAQSETEAKQEIQQLHKELIEAQELARTSKQKCFELQALLEEERRAYRVQVEESNKQINVLQAQLQRLQEDIENLREEKESEISSTRNELVSAQNEILSLQQVAEKAASERDTDISALQEELQTVRAELERWRKDASDYEKEIVSLQASFQLRCQQCEEQHKEEATRLKGELEKLKAEWSVLEAECVTLRKENTSLASELQRQEKELSSSQKQSLALTSNISVLEMSRKELEDQMGSLREKHQQDAASLKSQLSEAESQAKDVQKEYERTQTVLSELKAKYEMAEQEKQSITEELKQCKENLKLLQEKGNNPSILQPVPAVFIGLILAFLYWCYGPLW
The following text describes a protein:
Function:
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
Subcellular Localization:
Plastid.
Sequence:
MTRIKRGYIARKRRTKIRLFTSSFRGAHSRLTRTITQQKIKALVSAHRDRDRKKRDFRGLWISRINAVIRGNIKVYYIYSNLVYNLYTGQLLLNRKIVAQIAILKQNCLFMIANDIIKTKNPLRLYSGKV
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MALWASAAFRSLSEVSGPSSRLVPDMTDRKPARDRQQHGMALASLRNPVGPSSTPRNLKLKSLMDHQRSALARRHLTMMETLEGGILCECCRTGPRPGTAAGREERMRQQFRTRSMAAEHQRGEGSEDDEEDPVFRLIIDGDAIHTVDWPIMDQAAVGPDNAKAIVNGDCSAAGSEKNGAHANGAVHTNGATTTTTNQHDAHANGAMHTNGATTTNQHGVHANEAMHTNGATTTTTTNQHVNGIDTRAAEAERANQELTKDHGNGRGYETNGAHNYDHDHMHSNGATTVDRSEAGATAEPTLNGATTVDASTPPAAFVEQSKKVYIEKPTEAQAPATSAKPKRAQLKPAPSAEELDGQHIQVRKFLKNKNLLYIGVTGFLCKVAAERTLDVQPDVGTIYVLVKPNSTGDAQARLRKDIIGSEIFEALKKKYGEERFLEFMKQKVVAIPGNIVEKDLALAPADAKMLMERIDVIVNSAATTKFDERYDLALELNTFGPYNVLEFAKKCSRRPMLVHISTAYVNGKRRGVSKEEPFEYGQTLLPEIQDFADDPDEPDDSSGVFSEWRKQAVTKLIKPFWPAPADKVKAARKNRMIESLNEFLLENDAETAFVNPEKELELALKCRAAREPVDEKLPVEEKQREEEKQRVEEKQRMELLGHMRANTFGWQDAYVFTKAMGEMMLMKYKEDLPIVIIRPSVVESTLKKPFDGWIEGNRMLDPIVLHYGKGDLTGFRVDPDVTLDIIPADIVANVILAAMAKHGGYEQMYPFVYQVASSASNPLTMRQIADTAYEHFSEFPMQKKEKAEENGKKEEEEIKELVYRPMTFITNERDFQALLFFRYGVPMQLMELMSRFLNLPWIKKLIGGRNENPVVKIVQHWKRNCVSHTRRIGLLLSSVTHMAEVYKPYVFYKGRFDATNSEMILTEIAPEERSMFSYSVKNVDWRSYLRDSHFVGLRQHVLKWLRCKKIGRNWTIVIPPSDPEWIGRGDER
The following text describes a protein:
Function:
May negatively regulate cell cycle progression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAENSRSEALLPLRNLWNSVKCSRDRVRDGESNDSSGTFSLANFWEILNEAVKAVSQEATKLSLMFSKPPLPSDEDCAKMGECVQKSVLTLCTVYFWLPKSQGVTLRRSVRDATAEVLEGLVQLLDVILSSPGQSLSQEQLTSTGSVWAACDHFDQIPKDNRSAVLAVLSSCVGLVKDALEEMQQALAESQDPFGDVLDDDDDDEGGRGNQDRYWSASDRQLIGQCEGLLKASAASLRKLSSAVRHNAQLETEQEIAQLDDLADAAAHVSPCVDDLALSLYPPVDRAAVEQNVCRLAAVLKKLLDITRSSHVCAEADVSWVEFLSGAVEHNLEKVRSLLRSDS
The following text describes a protein:
Function:
Processive enzyme that polymerizes GDP-mannuronic acid.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMETYKRGLAEATGWLVFLSLLMVLALAVPKTVFDADSKDFILLIGAVGIWRYSMGGVHFLRGMLFLHVVYPYYRRRVRQLGSAADPSHVFLMVTSFRIDALTTAMVYRSVIREAIDSGYPTTVVCSIVEMSDEVLVRSLWEKMNPPDRVSLDFVRIPGTGKRDGLAYGFRAISRHLPDDDAVVAVIDGDTVLDHGVVKKTVPWFKLFPNVGGLTTNEFCEVQGGYVMSEWHKLRFAQRHINMCSMALSKRVLTMTGRMSVFRARVVTNPEFITDVENDHLEHWRLGRFKFLTGDDKSSWFSLMRLGYDTFYVPDAAINTVEHPPEKSFIKASRKLMYRWYGNNLRQNSRALKLGARRLGWFTMLVLFDQRVSMWTSLLGLVVAILASLKYSIAFLLVYLLWIGLTRLVLTLLLSLSGHRIGPAYPLILYYNQIVGALVKIYVFFRLDRQSWTRQPTKLERGLASFQRWFNAWSSRAMTFSAASIFVAVLLTIV
The following text describes a protein:
Function:
Probable RNA-binding protein that plays a role in meiosis and vegetative growth.
Sequence:
MEKHLQDTMLGRFEGAFKIPSVNNPRKLESNAWGILHATEAYHASSDTSLFSSSLPVLPHEKLNFSDLEHLGQSVDDSLPSLNNVEQENEIKDPLENVESNAFGIMLPDDEDDLLAGITDDFDLSRLPNQLEDVEEYDLFGSGGGMELDFESQDGLGIGMSKLSISDGVVPNGIGHYALPNGVGAVAGEHPYGEHPSRTLFVRNINSNVEDSELRTLFEQYGDIRTLYTACKHRGFVMISYYDIRAARTAMRALQNKPLRRRKLDIHFSIPKDNPSEKDINQGTLVVFNLDASVSNDDLRQIFGAYGEVKEIRETPHKRHHKFIEFYDVRAAEAALRALNRSDIAGKRIKLEPSRPGGARRTLMQQLTQELEQDETRSFRHQVGSPLTNSPPGTWAHIGSPIEHNQPAFSKSPGLGSLSPDSNHLPGLASILPAHVSNSPKIAPIGKDQGRLNPINQIYSNSTSTQGAGYQHSHSYPEQKLSASPGPISFGESNSNSAGIGTLSGPQFLWGSPTPYAEHNSSAWPTSSVGNPFSSSGQGQGFSLSSRHGSFLSSHSQHVGSAPSGVPLDRHFGFFPESPETSFMNPVFGGMALSRNSGNYMMNMGGRATLSAGVGLPGNITENSSPSFRMMSVPKHGPMYLGNGSYTGPAATINEMLADRSRSRRIENTGNQIDSKKQYQLDLDKIISGEDIRTTLMIKNIPNKYTSKMLLAAIDENHCGTYDFLYLPIDFKNKCNVGYAFINMVSPSHIIAFYEAFNGKKWEKFNSEKVASLAYARIQGKAALVTHFQNSSLMNEDKRCRPILFHSEGQETSDQETFLSRNLNICIRQPDGSYLGDSLDSPKGDLDEKPENS
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Sequence:
MQTHEILLKIKEIAKSKNFNLNLDEKTINQPLRELKIDSLDMFSIVVSLENEFGISFDDEKLMNLKNLADLVLEVKNLLAKKGV
The following text describes a protein:
Function:
Involved in sister chromatid cohesion during mitosis and meiosis. In association with the gsp-2 phosphatase, it both restricts the localization and antagonizes the function of the air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. This in turn, drives germ cell immortality. Furthermore, may play a role in ensuring the timely assembly of the synaptonemal complex during prophase I of meiosis.
Subcellular Localization:
Chromosome. Nucleus. Note=Recruited to chromosomes by smc-3 which is a component of the cohesin complex, and the proteins htp-1, htp-2 and htp-3. Localizes to chromosomes in the mid-pachytene phase of prophase I to the end of meiosis I. Localizes to the long arms of chromosomes during diakinesis phase of prophase I of meiosis. Does not localize to chromosomes in meiosis II. Localizes to chromosomes in prophase of mitosis in the first embryonic division and subsequently from late prophase to anaphase during early embryonic division.
Sequence:
MVSHKKNDRPRPLWILKIHKRLSLFEFKRYATGIGKDDGQDISWVLKGNAKNNVYQVTVETMENCETDECKKVIWVPDELAESTGTMFEDFKEDQPQESVSSISNNEANWGSSVNELDENYEKMQKEETFDPYDSDSDTSEDSDFDEDFEDSDKTMCSGQS
The following text describes a protein:
Function:
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. Also able to use styrene as substrate. The beta subunit seems to have a structural role in the holoenzyme.
Sequence:
MMINTQEDKLVSAHDAEEFHRFFVGHDSDLQQEVTTLLTREAHLLDIQAYNAWLEHCVAPEIKYQVISREFRSTSERRYQLNDAVNIYNENYQHLKVRVEHQMDPQNWANSPKIRFTRFVTNVTAAKDKIVPDLLHVRSNLILHRARRGNQVDVFYATREDKWKRIEGGGIQLVERLVDYPERILQTHNLMTFL
The following text describes a protein:
Function:
Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation. Plays a role in meiotic recombination events. Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MSDEKKKKRGFFRYSVLTTSSFSSWRRSSTSGSISQSSRTTSKTTTSSSVTSSNPINAPPPTATSSSSVLPSTSSEPPPPASAPPRISIYHKMVPSKSKFRQCDVCEHIFIFDFVRKQHLDDVYACNVCGIRVHKGCLDRVKNDCKITTQYMGGILENAVIQSNKKQWEKPTTASISKSLTTSPTCSTSTTMSPAGVEKNVHKTRKLISMTTSTLDDVTTFNSEINEEMDEETVLMTWEDVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAAVRFVNMNYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTNTYAIVTNFYQHNTLYHRIHEQLSEDFDQSWTFQISLQICQAMSYLHKKKILHRDLRTKNILLDNPNRVVVTDFALMKLERLENPRRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYSFGTIFFELLLRRMPTGCDSWDQKLYAKMCGQKAALQRLDAQLQKIDGKLHELLLECWSSQPEKRPSFQQIVKRITVQMPRKESNKQKRRSTAHENPLF
The following text describes a protein:
Function:
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3'-5' exonuclease activity. The delta subunit is the wrench that will open the beta subunit dimer. The DNA clamp loading complex (tau(3),delta,delta') is thought to load beta dimers onto DNA by binding ATP which alters the complex's conformation so it can bind beta sliding clamp dimers and open them at one interface. Primed DNA is recognized, ATP is hydrolyzed releasing the clamp loading complex and closing the beta sliding clamp ring around the primed DNA.
Sequence:
METTIFQFQKTFFTKPPKERVFVLHGEEQYLIRTFLSKLKEKYGENYTVLWGDEISEEEFYTALSETSIFGGSKEKAVVIYNFGDFLKKLGRKKKEKERLIKVLRNVKSNYVFIVYDAKLQKQELSSEPLKSVASFGGIVVANRLSKERIKQLVLKKFKEKGINVENDALEYLLQLTGYNLMELKLEVEKLIDYASEKKILTLDEVKRVAFSVSENVNVFEFVDLLLLKDYEKALKVLDSLISFGIHPLQIMKILSSYALKLYTLKRLEEKGEDLNKAMESVGIKNNFLKMKFKSYLKANSKEDLKNLILSLQRIDAFSKLYFQDTVQLLRDFLTSRLEREVVKNTSHGG
The following text describes a protein:
Function:
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Subcellular Localization:
Nucleus.
Sequence:
MAANSARNTLLWLRENYHANVRQGWLDECIDFIKRTNSGRSITQHQLNQLVYDKFLLADLQEIGEASLPQIKDEVMMVEGTYCLQINSVINVGQSAYSQIMKIKGKDDPESHLDKKHTNVIIQGPIAYRLGVLLLTRQCLVRILGGSTESLVETNSTWNLLHSSIGQEPPEPPAVVQILEDEAESSSSKPLNKNTQNVSMQSSTRNTFCKSTARSCQNFFENKHQMITPGVDSSIRANLRVTGKIPGNERVNNNWPNTRTSIGKSKLQTTHCKSLQRCDSWGERTDYFDDDDNELLDEDLFSDDIEENLDFDQLDQLEKGALPIRNSASENIASLHLQELQDVFENIDYQDLDDFELDNTNNGSIILCEKTIKRKEDNSRVCSFGVDTGITDYSSKGKFPMKQRVNTEDEISEQVCKKQRQAYAPPFGNSINPKSEKHPTFGKDRQGVLEGMEVIDVDHPVIKPNDQITKLDKMESMGRSYSLESLPFTYLKTVEQHLPFQEDITIRIKAYVSTLVNHSQTPGTGWCVTVKVNDGTAAMDMDLGAEVLTELLQMPVESFQ
The following text describes a protein:
Function:
Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. Probably involved in the export and assembly of fimbrial subunits across the outer membrane.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKIPTTTDIPQRYTWCLAGICYSSLAILPSFLSYAESYFNPAFLLENGTSVADLSRFERGNHQPAGVYRVDLWRNDEFIGSQDIVFESTTENTGDKSGGLMPCFNQVLLERIGLNSSAFPELAQQQNNKCINLLKAVPDATINFDFAAMRLNITIPQIALLSSAHGYIPPEEWDEGIPALLLNYNFTGNRGNGNDSYFFSELSGINIGPWRLRNNGSWNYFRGNGYHSEQWNNIGTWVQRAIIPLKSELVMGDGNTGSDIFDGVGFRGVRLYSSDNMYPDSQQGFAPTVRGIARTAAQLTIRQNGFIIYQSYVSPGAFEITDLHPTSSNGDLDVTIDERDGNQQNYTIPYSTVPILQREGRFKFDLTAGDFRSGNSQQSSPFFFQGTALGGLPQEFTAYGGTQLSANYTAFLLGLGRNLGNWGAVSLDVTHARSQLADASRHEGDSIRFLYAKSMNTFGTNFQLMGYRYSTQGFYTLDDVAYRRMEGYEYDYDGEHRDEPIIVNYHNLRFSRKDRLQLNVSQSLNDFGSLYISGTHQKYWNTSDSDTWYQVGYTSSWVGISYSLSFSWNESVGIPDNERIVGLNVSVPFNVLTKRRYTRENALDRAYASFNANRNSNGQNSWLAGVGGTLLEGHNLSYHVSQGDTSNNGYTGSATANWQAAYGTLGGGYNYDRDQHDVNWQLSGGVVGHENGITLSQPLGDTNVLIKAPGAGGVRIENQTGILTDWRGYAVMLYATVYRYNRIALDTNTMGNSIDVEKNISSVVPTQGALVRANFDTRIGVRALITVTQGGKPVPFGSLVRENSTGITSMVGDDGQVYLSGAPLSGELLVQWGDGANSRCIAHYVLPKQSLQQAVTVISAVCTHPGS
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MNENGATPVAAARRHRPLPAERATSNSNETGLLINVIRSLTSSVSEDQREVEKSRLEKGYKESGALIDRLVKNHQQDVEKCLVSFRDVSSKISNCRERIHNVRNALHTVKSLLELRRDDLKKLWHENAQQKSVCEIMAKLEELREAPSKIENLISKEQYQQAADTVTESRELINGRLSRVEGLSHLSAEIERFTKILIDKINDTLVNMLVVEPFEKHLLHIVRTIPEHRINQNAYCHSLSTKSRSGSGSVSSFSDVSAKSRIVSSVEALSTLFRTVEERHWDVDRLMMLGKNMIDKMIVNTVQVMKIGANIDESNEGDTTHLKQLMQLLSAQFDSASQQHAEFGVLVEKQLGRKDVVTSFWRSAQSAIEVVVSEHLDINPLLEKQNVLGTASRKQLFRFENTACATPNANSSSHRTKAVICKPSAYNIKVIFPILSRLMETTEKNINDSPCELRRFMHSFVMEVFVERVKGELASRIEGALRGGEAVRVSTNKKILPSCEKVLNLCKEVQDLIVSIDLYADRFAALWLLVLTDYFKNMTDVYDRMTPKNPDPSLPNSEALPTRRQKISAAWTADDDISRLLMSLPNWHAASISPMTPAVESELDVGERNKRESEILIGNLGTQAQNSLSESDLITDMNDIKMFASLHESLRWFSDEIRELVHSLPANVKMMLDTCMVQVRLKDGQMIDNNSVPSAIEDCVRRLESIADSCLLLLHIEIRVHCFFHLAPLAKYRNTSSHNEVDPEVVALGKDLHQFHDNLKDVLSPAKLSYVFDGLGHLCASLFIHYSQFMPRLTEAAKKRVCRNVWGVQQRLSRITNRRESDLDRARAFFDLLLDNTPDGILAIVPEKRSQFTATELNYLLALSVRSDKTLASQPGALEKRQMVLNSILNQKK
The following text describes a protein:
Function:
Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP) (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPILVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MAVSVAVITLAILLSEQADGRRKFRDNPVIPSARPSLVTSEEVTQFCSLMPWMKPHQKQKCLLEPLVMPSVQRGVGMALEECPNHFSDHKWNCSGVNTAQVFQERGILKTNTKESAFVFALTSAGVSFQITKGCSLGNWEQCGCDTQVRGRVQTKDEASWEWGGCSENVGHGDDFSRKFMDPEPPRKELEYLLVKHNNEAGRKALKDNMGKTCKCHGVSGSCTVKICWRTMPNFSVVAQLLRKKFDQATKVKANDKKTKLQRITRGKRGKKKRQKGRRPSAGDLVFAEKSPKFCIPNPELGILGTRGRVCDANAKDNRGCKKMCCNRGYDTFKLSNQVKCNCEFIWCCKVQCDMCKKDWTEYRCR
The following text describes a protein:
Function:
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN.
Subcellular Localization:
Cell projection, lamellipodium. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAAEREPPPLGDGKQADFEELEDGEDLFTSTVSTLESSPSSPEPASLPAEDLSTNSNGPKPAEIVLDDDREDLFAEATEEVSLDSPEREPILSPEPSPAITPITPTTLMAPRIESKSISAPVIFDRSRDEIEEEANGDVFDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFNKNEFSVKRRFSDFLGLHSKLATKYLHIGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHASVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYVFSELLSDYIRLIAAVKGVFDHRMKCWQKWDDAQVTLQKKREAEAKMMLANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA
The following text describes a protein:
Function:
Vacuolar transporter which plays a role in sequestration of divalent heavy metal ions.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MDIPSSNQIQHGQRSERNRRMPRASFSSTATTSTAATLTSAMVLDQNNSEPYAGATFEAVPSSIVSFHHPHSFQSSNLPSPHSSGNLEQRGRRLTESEPLVLSSAEQSRSSSRNPSHFRFFTQEQISNAEGASTLENTDYDMAWDATPAYEQDRIYGTGLSSRRSSIRSFSRASSLSNAKSYGSFSKRGRSGSRAPQRLGENSDTGFVYHSATHSSSSLSRYTTRERIPIELESQTDEILEDESSTHSLESSDSRRSASENNRGSFSGHDDVHNQHSEYLKPDYHEKFYPQYAPNLHYQRFYIAEEDLVIGIAAYQTSKFWYIIYNLCCFLTFGLVYLLTRWLPHLKVKLYGVKVPLAKAEWVVIENEFGEFVIQPIDRQWYNRPLSTVLPFENYPNPSYEPNDINLSHHHANEINPNVPILITFEYRYIKFIYSPLDDLFKTNNNWIDPDWVDLSTVSNGLTKGVQEDRELAFGKNQINLRMKTTSEILFNEVLHPFYVFQVFSIILWGIDEYYYYAACIFLISVLSIFDSLNEQKKVSRNLAEMSHFHCDVRVLRDKFWTTISSSELVPGDIYEVSDPNITILPCDSILLSSDCIVNESMLTGESVPVSKFPATEETMYQLCDDFQSTQISSFVSKSFLYNGTNIIRARIAPGQTAALAMVVRTGFSTTKGSLVRSMVFPKPTGFKFYRDSFKYIGFMSLIAIFGFCVSCVQFIKLGLDKKTMILRALDIITIVVPPALPATLTIGTNFALSRLKEKGIFCISPTRLNISGKIDVMCFDKTGTLTEDGLDVLGVQISEPNGVRGQKFGELLSDIRQVFPKFSLNDCSSPLDFKSRNFFMSLLTCHSLRSVDGNLLGDPLDFKMFQFTGWSFEEDFQKRAFHSLYEGRHEDDVFPENSEIIPAVVHPDSNNRENTFTDNDPHNFLGVVRSFEFLSELRRMSVIVKTNNDDVYWSFTKGAPEVISEICNKSTLPADFEEVLRCYTHNGYRVIACAGKTLPKRTWLYSQKVSREEVESNLEFLGFIIFQNKLKKETSETLKSLQDANIRTIMCTGDNILTAISVGREAGLIQCSRVYVPSINDTPLHGEPVIVWRDVNEPDKILDTKTLKPVKLGNNSVESLRECNYTLAVSGDVFRLLFRDENEIPEEYLNEILLNSSIYARMSPDEKHELMIQLQKLDYTVGFCGDGANDCGALKAADVGISLSEAEASVAAPFTSKIFNISCVLDVIREGRAALVTSFACFQYMSLYSAIQFITITILYSRGSNLGDFQFLYIDLLLIVPIAICMSWSKSYEKIDKKRPSANLVSPKILVPLLISVFLVFLFQFIPWIIVQKMSWYIKPIVGGDDAVQSSDNTVLFFVSNFQYILTAIVLSVGPPYREPMSKNFEFIVDITVSIGASLLLMTLDTESYLGKMLQLTPISNSFTMFIIVWVILNYYAQLYIPPSIKGWLKKKKSSKKYKLLIQEEMKLKEV
The following text describes a protein:
Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular Localization:
Nucleus.
Sequence:
MSSHGLTVGFLAEIMQGNELQNPVVQILGSKRIAGNGEQSERFRLLISDGKSLYSFAMLATQLNDLQKQDKLPQYTIIRIDRYTTSVVNRNEKGEKRVLIIVELTVLKEGSLVGEKIGDPQPMTDTPSQPATTQAPARPMDTGSSSMGNGASYGSANRSLSGGSAGPTQSIGDSLTHPISSLSPYQNKWVIKARVMSKSGIRTWSNAKGEGKLFSMDVMDESGEIRITAFKEQCDRYYDMIEVDKVYFISKCQLKPANKQYTSLKNDYEMTMTNDTIVQECKDADGSMPEIQYNFVPISQIANMEPNAMVDVIGMCKDASDVVQFTAKTSGRELRKREITLVDSSNASVQLTLWGDDAQNFPATTHPVVLLKGARVSEFGGGKSLGLIGGSVMKLNPDLEMAHKVRGWFENGGSEASVSSVSARTGGAAGVSTEWLSFQEAKDKNLGAGDKPDYFQVKAMIHTIKSANAVYKACPQADCNKKVIDQENGQFRCEKCNAEFPNFKYRLLVNMLIGDWTSNRWVTVFTELAEEMLGKSSQEIGSSLEYQKEEAEKLFTSISFKSFVFKLRTKVEYFGEQPRNKTSAVSVAPVNHKEYNALLIKSIQELTGVGKN
The following text describes a protein:
Function:
May be involved in zinc transport from the cytoplasm to either intracellular organelles or extracellular spaces.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSDINSNSYDPYHHPQQHQQESQYHPQQQQQQQQQQQQQQEYYNQQHQQESQYQQQSPPQQQYDNHQHHQQDLNQAHNSGHGRSHNSGHGHSHGNNYSGLPHLRTQVGHAQPYFSSYNELNNSGDISNSNNNNNNNNQYNYNNNNNNNNYNNNINNNQFNSSVYNNNNNNNNNNNNEFSIDGKSGITIKHLLNNLNRDSDAKKLAAWISVMLVFTIYEIFYGAYLESLGLVSDGFHALFDCIGMGIALLAMLVGKRGISNQEYTYGYDRWEVLGTFSNGCFLLFVSFFLFLESIERLLEPPHIHNHGRVMSLATISLIINIVGVLFFKQKSNERKQQSSIRSENLLTISHHILVDSCTSLGVILSSLVGQAFGLEISDSLISIIIACIIVYNALPICIKTSAILLQTTPDQLKININNAIKDILVMEGVIDVTDKHFWSHSPGNIIATVNLLTKKNCDDFTLTQSIRNRLSFVQDLTIQLDKEGKHNSHSHGGAHHHPHEHKEDKKSHNHSHGHNHGHSHGHSHGGNDDHEHGENCDEEHEPVPKYQVQPTSPFSSHYTDIHSNNTPIPLYKSEQDDEDDEDDYDHDEHHHDHDHDEHHHGHSHNSSHSHAHNH
The following text describes a protein:
Function:
The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MALVSRRSTRSESTSITKEEHTGEGSLTKLFFRWLVTLEGDQDINDGKGYISLPNVSNYIFFLGGRFRTVKGAKPLWLGVLLAIVCPMVLFSIFEAHKLWHTQNGYKVLVIFFYYFWVITLASFIRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDITIKYCPSCRIWRPPRSSHCSTCNVCVMVHDHHCIWVNNCIGKRNYRFFLIFLLGAILSSVILLTNCAIHIARESGGPRDCPVAILLLCYAGLTLWYPAILFTYHIFMAGNQQTTREFLKGIGSKKNPVFHRVVKEENIYNKGSFLKNMGHLMLEPRGPSFVSARKPHEAGDWRFMDLSPAHSFEKIQKI