lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Note=Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
Sequence:
MDRVWRAWDGQSFKENQPESPSARGIVVSWLSRAEWEQVTVYLFCDDHKLQQYALNRITVWRSRLGNELPLAVASTADLVRCKLIDAAGTLGTDELRLLYGMALVRFVNLISERKTKCSNLPLKYLAQEVNIPDWIVELRHNLTHKKMPHINECRRGCYFVLNWLQKTYWSRQLEGSLKETWELDEDQLDAEDPEEEEREIIADDVLEEIPEPQDDDKDEELAVEDDANTKGNEEVASHPEPSSRHKELYEKARELLVSYEEEQFKVLEKHRHLLQAIKVWNNLSPRVQCILEELKSISWENRDAVLDAFLDDGFLIPTFEQLAALQIEYEDGQTEVQKGEVTEPNSHKNIDLNEVLVPKPFSQFWQPLLRGLHSQTFTQALLERMFSELSTVGSTGIRPTYILRWTVELIVANTKTGRNARRFSASQWEARKSWRLFNCSATLDWPQVIESCLGSPCWASPQLLQVVFKAMGQVLPDEEQEKLLRVCSIYTQNGENGLAKAIEGSSSSSTGKAPYTLDTLHEDLQPPGTNCESEESIQQKEQGNLKDVKQEEKKENEEEEKEEEEMEEEEEEEEEEKEEEEEEQEQEEHQEEEQEEEEEEENQKVFQDQMEADVEESDDVEEEEEVDDEEEDEDDDYDDDEEEDRMEVGAFSLAQGSSVFENTRTTSRKREALQGSAWQVSSEDVRWGTFPLGRLPGQTEDPAELMLDNYDTMYLLDQPVIEHRLEPQKSKSSTLSLCCGGSNTNSSSSSSSGNMEGLLWNQGQMHGLKAGLQLF
The following text describes a protein:
Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).
Subcellular Localization:
Endosome membrane; Peripheral membrane protein.
Sequence:
MGILFSHCSGGREKEDKISKTDRAVLNLKIQRDKLKNYQTQVLEIAIAKECSKAGKKNQALLALKKKKYQEKMLDESFANLQNIEELIANVEQAEIQVRIFESLKQGNESLKEIQKEMSLEDVENLMEETAEAIQYQNDISEALSGKFSKEEEDDLLNELDEMEKQLNAQQYPKVPETQLPKIELPIEDAIEEGKQRKSTTNGLNHILIIACIINHIF
The following text describes a protein:
Function:
Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MGGPRSTNIPGVKKGRRARCSHAHFGDPAAGRTAKELTYPDTRTGAEQRARHAPNPLRLLLALLGPGYLRSPSMLSSSPASCTSPNPDKENPSKKVHWASGRRRTSSTDSESKSQSDPFRPRSRKPSRLTVKYDRGQLQRWVEMEQWVDTQVQELFQDQPTSSEPEIDLEALMELSTEEQKTQLEALLQNCPRPTEPFISELLSQLKKLRRLSRPQK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MQKTNIKSVTARNEQAKAKLTKEQFLTLAKMCQSTSTQQLLNKKQPSQQKPVLASQLNITPRNNTPKSCRTAQEMKYFLYQKNLVKDSINKPQNHSQLLPKTKNSLHRNFSQLEKSSNSQQNNGQSTAPNTVKKKYNLLSTDSANKLDYRFSSVQFAQQIVQQLKKKFEPQQPQQKKENLHVSLDDFVTQINRPQSIISPFKQTKSLSPSTRVNNVPSKKSLYYVSSLVESFRHILPQNQEQQLFRDHAVQTFNCVSFCVKLQEATQLILEQKRMDIPMKSHYKFKKTVVFDLDETLIHCNENQNLKADVYLPITFPSGDTAQAGINIRPYAKWILQELSQLCEVIVFTASHQCYASQVIKFLDPNSNLLSGQLFRDRCVLSQDGVHIKDLRVLNRDPKDIVLVDNAAYSFGVHLENGIPIIPFYDNKEDKELKMLYDFLVDQVLPAPDCRIVLQSVFRLREYYNYGEPKQAIEKLY
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MAETSNDTPWTVMRLLEWTTDFFRKKGSESPRLDAEILLAHARGCQRIELYTSFDKVPEEEQRVAFRELVRRRGEGAPVAQLVGYREFYSISIRVDENVLVPRPETEHLVIEAIDQIKGRLSDRPSPTVLDIGTGSGAIAVAIAKSLPKTQVTAVDISLTALDIAKWNVENLKLSDRVTLLQSDLFDGLEPDQTFDVICSNPPYISQSEYDELPTTVREFEPRGALLSGPDGTEIIARLLNDSVQRLNDGGQLIIELSPMIAGVSKTLAEQNGGYKEIHLIKDLAGHERILSMQKA
The following text describes a protein:
Function:
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Note=Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.
Sequence:
MSSGVQPTQECLEKFQELKTGKKLTYVIYGLSEDKRSIVVLKASEDKDFDSFVAELPEKDCRWAVYDFEFTLPGGEGVRNKLCFIVWSPDDASVKNKMIFASSKEAIRRRLDGIHTEIQATDFSEITKDALFEKATRK
The following text describes a protein:
Function:
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVDFTTDELDEVASLIARSSCNVALTGAGVSTASGIPDFRGPQGVWRRVDPEKFEISYFYNNPDEVWDLFVKYLLPAFNVKPNPAHYALAEMERLGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVCTNCGSKYALAEALKWRKSGAPRCPKCGGVIKPDVVFFGEPLPQDALREAFMLAEMAEVFMAIGTSLAVYPANQLPLVAKKRGAKLVIINADETYYDFFADYIIRGRAEEVLPKLLDRLRGMLF
The following text describes a protein:
Function:
Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MVRFSTPLVLASPSLSTLHPLSLPRTHTRNDTCMQAHNSTVAHSVSRAPFSLPPSTHPPPAPTPLPHAHTHTHTKTLCHSPFSGVWVLVCVCNSSVWGVSLLYLFLFVGASFQGIVLHAWKQRIGTRARTHLEVWAAAPPLPSPLSLSSAMSARATTFAGVTFDPHGTSMNLTTASAAGAEPSAEIEQLRQKLSLDLQCQPELRALLELCGESNAWTVEEAMQQPDTITTIELFLFHVPRVPLVQFFPNLVTVKFMSIGLESMANLASLAHVEELWLSDNNIRVIEGLYNMTRLRRLYLQGNRIESLNGLPPLRHLRELWLSRNRLSALIHLTPLRKLRSLYVSCNPLESLENAFSKDMSHLHEVNLSGCHLSSIIELRHLQQLTCLRSLWLLDPLFGDNPICRLNNYVTLTISMLSSLDTLDGTFVTSEQRSLVESVLHKKQLYYAMRAQMLDTRITLLARHAETCALRHTRDTGRALLKLKSCVQPIEHELAERTIYHLDDKHGAGGSSGSLCGVIAGGDKGGDYAGGAPLVVPTATLEALGRQLSRAIDTREVQERKTMLKLAEATQAAKLQAQLLKERFAVELHTAGNVRLEHLAPDHEAYGAAVELVQERFDSALFDERFGIAEVEVTGVRRILNRGLRLRFDDRVKELHVDLANPQLRSRFVGLFGIVPVTQQGQSACLQHVLVNGMAARLAAPSEDGKKSGVASQAGRTLYQPVPAEEGVPLTNSLFYADEERLLSCCATTGGASRGCDSSPPVLQQSYNAAALSSGSEASTLCRGQVVLYRVYLGKTVHALGGGGCVGRSTSPPPPASFLKQNGRVWRKDYGADTCAAYRLLPSTAATTPAGESGSASAQPSPSPYVWYCFDRALLLPDCVVDYTYSMRNTPLTQPSRSPLPAGGGASCMSRAEAMALLAGLPLPPVVGCEASSADADDSQHSGKGTDTVEDVLHCGEQLLQFIYWCSPPSKHAHSRDTASHGNTLQQVAEAETNEALASACKVLGKACMAGLLRNGAVDDTAGGGDDRSNDASSSSAANPLHARHVEEYAAQMCVNGAPLSLCALRSRGITAVLQDFATPLCASITALDLAHNRITSVSWFALAKEVPQLQWLNLSGNALSRLHFDGSALPSLRVLDVSNNELGSVTDFAAIRTAAGALEELVVYGNPFLRHADGQEAEARLWLYLLPPPTSAMAMAAGGSPAIVKLNAHSLGTYPGTLASQRFRRACLLPGGRVTPHVSRVTACLVKSIQRDDELSCAAASLLSVEGAATQESCFEQVAAQLEMLMVADKLEAHLREACQHPPAVDEARPRFPSEALGGSDLPLSPSLLSCLNECHTFRWSHGLLDDPRGLVDLLPNLCHLTLRGQALTDVHPLLHLHRLESLNLAENHLTELPCLEELRALRELVLDFNELTALPLTVGPLPALRTLSASGNKIAQVDINLFVRSTNGTAALGPPSPPTTTPKLEALYLMYNRIADMNVIYALRDVTSLLILNVAGNPCTAPRGAADDDEVRPYLIHVFPQLKVLDGVSISAAEMAKAREVYAGKVNSDLLIERARGPPETWASVRHLNLSHCSLKEVNLLEPFKSLEVLHLQHNLLVSVLGVAMLTELTALDLSHNRLGSAPWRNPIGGALSANSTGAPAAAGANGAATTSPAALGNTLARLKRLQSLSLEANQLTDLSTLKLCFPHLKFLNLRCNELQFIQRGLENLPELRELLLDQNKLRGLGSDSFAANRKLIILSAENNALRSVEGLQRCRALEQLRLGANRLGDLNALLNELQSCPLKAVVLVGNPIARKTNYRATVITRLTQLTDLDRRVVTQDERDKAASARMMELVAPPNVVIDMNYFAGMGAAPAGSPGLPLQNGLTMNGFAGAALNGGTAFSPRGRSVTVPVNGAAVRSSLSPPQLTGIRAAIVPNRRGGDADRLAANQRIRPYRR
The following text describes a protein:
Function:
Member of the two-component regulatory system PdtaR/PdtaS. This two-component system plays an essential role in mycobacterial adaptation to poor nutrient conditions. PdtaR probably acts at the level of transcriptional antitermination rather than transcriptional initiation; In addition, the PdtaR/PdtaS two-component system controls copper and nitric oxide (NO) resistance downstream of the intramembrane protease Rip1. This coupled Rip1/PdtaS/PdtaR circuit controls NO resistance and acute lung infection in mice by relieving PdtaR/PdtaS-mediated repression of isonitrile chalkophore biosynthesis. Two signals are required to fully inactivate the PdtaR/PdtaS system and mediate NO resistance: a cytoplasmic inhibitory signal through the PdtaS kinase mediated by direct sensing of NO and the production of PPE1-5', an NO-induced small RNA, to sequester PdtaR.
Subcellular Localization:
Cytoplasm.
Domain:
Contains a C-terminal ANTAR domain, which is a RNA binding domain.
Sequence:
MTGPTTDADAAVPRRVLIAEDEALIRMDLAEMLREEGYEIVGEAGDGQEAVELAELHKPDLVIMDVKMPRRDGIDAASEIASKRIAPIVVLTAFSQRDLVERARDAGAMAYLVKPFSISDLIPAIELAVSRFREITALEGEVATLSERLETRKLVERAKGLLQTKHGMTEPDAFKWIQRAAMDRRTTMKRVAEVVLETLGTPKDT
The following text describes a protein:
Function:
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MALYFVYLSTLLALILLGDNWAAGTYASRYTQHVDENQSGAAAQSGSKVTSRHRNWCAYVVTRTVSCVMEDGVETYVKPEYQRCAWGQCSHVVLYRTYRKPRYKVAYKVVSEMEWKCCHGYSGDDCSDGSSAIHDSRARPTGEEGRSDSDRIRQLEEQIQSLNKNLHNLQKKIYEESQREGISGGNNLADAAQPGMKETIHSIQTKLDMLDNMTRVHDKTLTNINNHLVGGNGIENELDSRYGTLKEEILRELERRVTLSCSSCQTGVESIQRQHQEDRERIRELEKHISVMEQHHQQTLDLLSRSQSCCDSLDRKLSAIDRKVSSTAETYDILRGRLEKELRSNGNGGRGKAMEEKLNNRLRDLERRLNGTVRKTEQKCSHTETSMKEFVQREIGQIKNSVLGRNDDHGYRISTVEIDIQDLKRFINDHKNNLERLGNKTNDLDSGLKSAIHLCTETCAAKGSETEDTVKSLEWKVVANEEDIKKFDTKLKDISVSGDSLLDRVIDLSNDVQKIKDLTGQNGEHFNQIVTDVENLGRDCDVCSSIDGELQKIRNVTSYAFDKFQAELTVLGRKVFSDEHVCSQVCSNLQEEVGKLKEEVEKCTGQCMISMADHQRNVDNQNTVTRKLGKDLKSIQGELTGILQIFNSINDTLKGLRNTIQKHGNNITDLNTSKGKIYLELDQLYDDLNKHKVDSKGHFDSISSFNSNLMTEMGECRLSREGLDKRLSKMEDVCGRLDTLSENLKTIKDGLSKHVSGLWTCVNDLNSTVISHSETISRIHNVHLENIQGRMNNLNSSIRNVLKEFQIFTEQDFTGPPGLPGPQGEKGSKGPPGPRGPLGKEGPQGRVGPVGPPGLRGEQGPPGKDANVPRLSFSAALTRPQASSGTIIFNKVFINERKAYNPKTGVFTAPVRGRYFFSAVLTGHKNVKIEAVLSKSNFGIARGDSAGYQPEGLEKPMAEARHTPGSLVIFNIVLPLQEGDTICIDLVTGKLAHSVEPLTIFSGMLLYEESEDRL
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination (By similarity). Plays no role in chromosomal or plasmid transformation but is required for resolution of chromosome dimers occurring as intermediates in the formation of merodiploids by transformation.
Sequence:
MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSKLAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQDNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAFDFSFKYGTCLCPEHYHEDERRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQFMDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MALRSLFSSLCVAVALAAAQAARTAVVLESASLQHTHSTFFQQLEARGHELSFFSGDEQPPLALERFGERAFENLVLFTPQKALGSLRKSDLLQFVEQGGNVLLSASKKLTKVQREFALECGVEFEQKGNVVLDHVSPISDDDDICNAVVAAQDFVRSERVVGALATSPKPVAFSGVGMSLEPSNILAFHALMAPATAYSANPVKPITDKVVASDLLFGNQIGLVTAVQGRNNARLLFAGSLDLFSDKYMQNKDFANAEFADAVTKWGFQEAGVLRMTNVKHHREDGSQPAKMLSDANRGDQPITLYPDAEVARDSLVYRVKDNLTYSLDLHELKDGKWLPYKADDVQLEFVMLDPHVRTTLTHDNKGHFSVTFQSPDVYGIFLFRVLYRRLGLSTIYTTTQVSLRPFKHDEYERFIPAAFPYYASAFSMMAGVFVFSVFFLFYDGKK
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell division.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Sequence:
MGDGVHTLLLDRPIVRDGRKFDAPLLWMVVLMTAFSLLMIYSASVYLASKEGGDQFFYLTRQAGFVVAGLIASGLLWFLCRMRTWRRLVPWIFALSGLLLVVVLIAGREINGATRWIPLGPLNFQPTELFKLAVILYLASLFTRREEVLRSMESLGWQSIWRGTANLIMSATNPQARRETLEMYGRFRAIILPIMLVAFGLVLIMVQPDFGSFVVITVIAVGMLFLAGLPWKYFFVLVGSVLGGMVLMITAAPYRVQRVVAFLDPWKDPQGAGYQLTHSLMAIGRGEWFGMGLGASLSKRGFLPEAHTDFIFAIIAEEFGFFGMCVLIFCYGWLVVRAFSIGKQSRDLGLTFNAYIASGIGIWIGIQSFFNIGVNIGALPTKGLTLPLMSYGGSSVFFMLISMMLLLRIDYENRRKMRGYRVE
The following text describes a protein:
Function:
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPS is more stably bound at the kinetochore than CENPX. During S phase, rapidly recruited to DNA interstrand cross-links that block replication. Recruited to DNA damage sites about 20 minutes following UV irradiation, reaching a plateau after approximately 40 minutes.
Sequence:
MEEEEWSEEQQRFSYLQRLKAAVHYTVGCLCEEVASDKDMQFSKQTIAAISEVTFGQCENFAKDLEMFARHAKRSTINTEDVKLLARRSHSLLKYITEKNEDIAQLNLEKKAKKKKKLEDENRNSVESAEAGVEESEN
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDVMNYFISIIKHTFVCLKSNQMDYCGQNLAYTIRNIIFGISTIISIIVGYYSQSLALSTYIILGGTALASILILPTWPMYNRNNIEWEKSYSSSNDKKRK
The following text describes a protein:
Function:
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MSFAEEFEANLVSLAHVLQKKYALLRDLDKSLQENQRQNEQRCEKEIEDIRRGRAGNITPNTSLTKFSEEALDEQKHSVRIADEKVTLAMQAYDLVDMHVQQLDQYMKKSDEVIRKEKEAAAATLELENNGKAGNAGEGGRGGRKKTRLATAASTAAASTGMTSSNMDLDLPVDPNEPTYCICNQVSFGEMVACDNNACKIEWFHFGCVGLKEQPKGKWYCPECATVKKSRKGR
The following text describes a protein:
Function:
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
Sequence:
MQLFWHRRDLRTTDNRGLAAAAPGVTAVDGGHDQGPVAAVFCFDDEVLAHAAPPRVAFMLDALAALRERYRDLGSDLIVRHGDPAAVLPAVANDLDATRVVWNHDYSGLATDRDAGVRDALDAAGVAHAQFHDAVHHRPGEIRTNAGDPYSVYTYFWRKWQDREKNPPAPEPEPADLAADTALADTSPLPSVQELGFAEPEAAVPDAGTAAARSLLDAFRESGDIYRYEDRRDYPHEEPTSRLSPHLKFGTIGIRTVYEAARAAKSDADTDDERENVAAFIGQLAWREFYAQVLYFNQNVVSENFKAYEHPIEWRDDPAALQAWKDGETGYPIVDAGMRQLRAEAYMHNRVRMIVAAFLTKDLLVDWRAGYDWFREKLADHDTANDNGGWQWAASTGTDAQPYFRVFNPMTQGERYDPDADYITEFVPELRDVPADAIHSWHELSLSERRRHAPEYPDPIVDHSQRREDAIAMFERARGDE
The following text describes a protein:
Function:
Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.
Sequence:
MSSNSLTRIAIVSSDKCRPKKCRQECRKSCPVVRTGKLCIEVTPNDRIAFISETLCIGCGICVKKCPFSAINIINLPTNLDQEVTHRYSANSFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILSGKLKPNLGRYDNPPDWDEVVKFFRGSELQNFFTKVLEDNIRALVKPQYVDHIPRAIKVADKRVNTLLSGRANNNNFEDIIKELELTGVLDRDVSLLSGGELQRFAIAAVATQKADVYMFDEPSSYLDIKQRLKAGRVIRSLLGATNYVIVVEHDLSVLDYLSDYVCVLYGVPSVYGVVTLPYSVREGINIFLDGHIPTENLRFRNEGLSFRLADVTEEATVERTANYNYPNHEITQGNFSLKIKSGEFSDAEIIVLLGQNGTGKTTFCKWMAKNSDLKISMKPQTIAPKFPGSVRMLFFKKIRAAFLNPKFQSEVCKPLNIDAIIDQEVLNLSGGELQRVAICLALGMPADVYLIDEPSAYLDSEQRIIASKVIKRFIINSRKTAFIVEHDFIMATYLADRVVLFEGEPSKRALCNPPQSLLTGMNSFLKMLDVTFRRDPNTLRPRINKYDSQMDQEQKASGNFFFLEN
The following text describes a protein:
Function:
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Subcellular Localization:
Nucleus.
Sequence:
MANVDVSSNLERHVARSTFPLLTRTKVCRNLFGPVDHEELHCEMKRKLQEISERDQSRWNFNFETNSPLPGDYEWEAISEDTLPFFYKDKVQNKRARAATSVNATGDASSTVDCGISRSPVAQESEGVPSRPNEPNQENISGALNSKPARSSVLRNRRKRSLIPESPRNSTPQITDFFPKRKRVVESKQDERSYLQAGTSTSIEVTPRKTIR
The following text describes a protein:
Function:
May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.
Miscellaneous:
MISCELLANEOUS: Present with 329 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Bud. Bud neck.
Sequence:
MILDPLSPNIENHTQDEIIEFWEKTESIANIPKENLDESHVNSSLVAYLKFATDSYKVFINTDRDLYRMSLILLESSLFEFKKEFCLSKLQSLLNIDLLEMNMKFIIVYILLCEAKKNVYSLEIMLKFQGFTVFYNTLYTQFAYLSKYGKERTVASKHQYNSNNSSTGTSLDSLDRSLTDIDLGIIDEMKQISTVLMDLLFQIMKYCKCVIANLQIVDDFFVYYMMESMRSDTMDDMFNNAEFKLLLALNEQYMMFAKEYDIENKVYKYLINGSVSRCFTELLLLKFNRASDPPLQIMMCKIIYLILTPRGDYSPMNFFYTNDLRVLIDVLIRELQNISEDEEVLRNTLLRVLIPLLKNTQLSKTHYRKDDLNKLLNYLSTLDNICVDSPALHEHQVTVALSRKCLQQIPWLETPSTPSDGGSSVSSNNTSRNSSIVALGTPDNQNILARKGHLYSNRELDVSAESLTKRKAKAPPPPPPPPPSRKCGTPK
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Sequence:
MQWPDVVDFSKFEVSAATFGGPIALLLKPSTANNKPIIFILSSSGKELGLIRWNSGSLLKVGWSLKEELLCIQDDGNVLIYDIFGNFVRNFTMGKDASNVKVTDAQIFITASSSIGVVVLTASFRFYMVTNIYDARVRQLPDFPGCDLPPSSWCILNRALTPQILIARNSDLYLLDMTGSCEKQQIDSSLHPAAILEMCLSWDNKYLAMFLSSGTLWIGSSDLKNTYCKYATDNYSRPKQLAWCGTGAVLMNRPMFLLLVGPNMDDVRYDYDSPVHLIQERDGVRVLSVYSHEFIQKVPKELEDVFKIGSVEPSAVLFESAKFFIEGKKEAHEYLKLIGNDLLHAVQGCLVASGYEFDVKNQKALLKASSFGKCFLKDYDSKPFIQMCRMLRVLNELKSKDVGIPLTLLQLNQLTMENVIKRLLLRKLYWVAYEMSRYIKLNDKNGTHLVLSVWACDKVGGIDVTGFVSQQHQQQQPISYRDIIDKAIAHNRIDLALKLISREVRVCEQVPLLLKLNREADALNAAIKSGDTDLIFLVVFQWKDKLAHGEFLRSIRLFPVAFQLYLQHCREQNVEMLLDIHYQEDNHADEAVCRIMLSYDDDKFERRLGSLIAAQEASVKAKNDFLAKLIEDQIKLLKLQRRLEEEMNLPFIDLSIDDTIGQLIGKEEHKRVEQMRKDFKLSDKRFWWLKIQKLAELGQWLELDKFSKSKKSPIGYEPFVDVCIKYNNVNEGKNYLSKVLPEHLVMYHIKLGLLEQAGDLAIQTKNEDDVDLVLSKCSATSNRELYNKLMTFQSQLKR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. bL36m may be involved in a process influencing telomere capping.
Miscellaneous:
MISCELLANEOUS: Present with 500 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MFLQTLRLTMPRMFLHMKPSPITITRACTVPSLLSVAAPQPALVAANRPLVFNRGFKVRTSVKKFCSDCYLVRRKGRVYIYCKSNKKHKQRQG
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MLTRDFIEDSLYNPSYGYFSKQVVIFTPGEPFDFNSLEDEPAFHRLLGQRYTEFEDELDLKSPNETRQLWHTPTELFRPYYGEAIARYLVNNYKIWQYPYHDLIIYEMGAGNGTLMLNILDYIRLTEPEVYARTKFKIIEISSNLASLQKSHLLRNANSRGHLSKVEIINKSVFEWNQIVPSPCFFLAMEVFDNFAHDSIRYDPVTEEPLQGTVLISNTGEFYEFYTPTIDPIASRFLRVRHAATNGKYPHPLPQNKLIRSLRNSMPFAPNLSQPEYIPTRLMQFFDILAKYFPAHRLVTSDFHSLPDTIKGVNAPVVQTRYKRRTVPVSTPFVHQGYFDILFPTDFAVMDNVYRAITGKFTQVLSHEEFLNRWAYVGQTETKNGENPLLTWYKNASVLTTV
The following text describes a protein:
Function:
Voltage-dependent high-conductance channel with a slight cation-selectivity; selective for amino acids but excludes triosephosphates or uncharged sugars (By similarity). Non-essential amino acid-selective channel protein and translocation pore for NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB.
Subcellular Localization:
Plastid, chloroplast outer membrane; Multi-pass membrane protein.
Sequence:
MEEELLSAVPCSSLTVESVLRVATAGGLYGLCAGPRDARKIGLSGVSQASFVAKSIGRFGFQCGLVSGVFTMTHCGLQRYRGKNDWVNALVGGAVAGAAVAISTRNWTQVVGMAGLVSAFSVLANCTRTENPNNTN
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTRCGRCRQCECAGASTTTSHGDARNRDNDAPDAVLEGLAMAGLVDILRQLGDLAELAAEVFDDMQDQVMAASARGRRLAARARKLLAADLDLVLDLDLPPPSTQEHRCLSSAAAATALATSGGAGRLGCRSYLGGAPPMPRVVVQRIERCRGPPRLSLLDKYIWPLIYDTMTCSAAACLISAPKSQLQCPIHAGTVVLRCRFDAAGDGACLKRYTDPSFFFRAHSAKIDEQGTLKQHRRQAEAAAAAGAAGSMFLLMQQTAAHRVEQPNMEQKLQEGSTAQPSPSELERTSSFEAWLSPQARRFPTATAATTHHHLQEPPDDDDGGGGGGATTCSGSISSQVDTTSNAAAVSSSSTVKAVRLNSASLVKGGESNTTRSRYKGKIASRVSSLPRKLFMNTTKHHNDHSRSFRAGSSSLRVTQATDIGDCSPELEAIAVAIPTPDADRCSNSNSSTPETCTAADSKNLLLLLPGSGPVLEPPDNSSAAAAEDAKVHTPLAPIPPMQWLSEKGTPPASPKHRTPCFQQQFGSSGQSDEKPSQEHEASDHSSNLLQESVFFSAAQELAKMSPPPPWVPRPKYPLLDVKALRNGPSPIHPSRNILDSRSAQIKDIAISSKLKPASRASSHVTGTGSPTNATILNRADGIRQRTAEAQRFQTQDFKISSDRTSMDVHLSVIFLSGLVKLEVFLFNFE