lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Putative serine/threonine-protein kinase.
Sequence:
MVNPVGSSKLEQNNIKSIIGSSYNRLYSQFTSDELTEVGNYKILKQIGEGSFGKVYLALHRPTHRKVCLKTSDKNDPNIVREVFYHRQFDFPYITKLYEVIVTESKVWMALEYCPGKELYDHLLSLRRISLLECGELFAQISGAVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDAKVIPDDARDLISRLLAKNPGERPSLSQVLRHPFLQPYGSVVLDQTQKILCRQRSGGTQFKSKLERRLLKRLKQSGVDTQAIKQSILKKKCDSLSGLWLLLLAQGKKQENCKYPKRSRSVLSVKKVIESATHNDTNGISEDVLKPSLELSRAASLSKMLNKGSDFVTSMTPVSRKKSKDSAKVLNPTLSKISSQRAYSHSIAGSPRKSNNFLQKVSSFFKSKKSSNSNSNNSIHTNVSESLIASNRGAPSSGSFLKKNSGSIQKSRTDTVANPSRTESIGSLNENVAGAIVPRSANNTTLENKKTSGNEIGLKVAPELLLNEHIRIEEPRLKRFKSSISSEISQTSTGNYDSESAENSRSISFDGKVSPPPIRNRPLSEISQISNDTYISEYSTDGNNSSFKISDTIKPSYIRKGSETTSQYSASSEKMTNGYGRKFVRRDLSIVSTASSTSERSSRTDSFYDITTATPVVTTDNRRNKNNNLKESVLPRFGTQRPWTGKRTYTTSRHGKNARRSSKRGLFKITSSNTDSIIQEVSSSEEEDHNVIYSKGKGLPTPVLQTKGLIENGLNERDEEGDDEYAIHTDGEFSIKPQFSDDVIDKQNHLPSVKAVATKRSLSEGSNWSSSYLDSDNNRRRVSSLLVEDGGNPTA
The following text describes a protein:
Function:
Secreted protein that acts as a virulence factor during infections.
Subcellular Localization:
Secreted.
Sequence:
MKFLQSFPVILAVFSFAANLVSSKLVYEYETKYVTVEIVTIVSGETTYTTERLETNGPTSTTTTIVIPSSKPSSPESKPKSDSQPMFQSPSPVQITPSTTSINNAPSPTKPETTVTASPAVIAHTSVFVVTPNSAPTTSSSPPNIVQQVKAAITPSAPKPQPQPQPQENNSGTNDDSQLSSFSRQILEAHNIKRASHGVNPLTWSNELYNYANKVASSYDCSGNLRHTSGPYGENLALGYSSGANAVSAWYSEGFNFGGAGKLNHFTQVVWKSTTQLGCAYKDCRAKGWGLYIICNYQKPGNIIGQELANILPLIRS
The following text describes a protein:
Function:
O-methyltransferase that catalyzes the conversion of mycinamicin VI to mycinamicin III in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic.
Sequence:
MTAQTEFDEATVQDVVRLAGGHDSELRELTQKYDPAMISRLLVAEILSRCPPPSNDTPVLVELAIVHGSERFRHFLRVVRDSPIRPVGADEGFVGMLVEYELTELLRELFGVTHERPAGVRGTKLFPYLTDDEEAVEQIGTYLLAAQQGTEAVLAGCGSRKPDLSELSSRYFTPKFGFLHWFTPHYDRHFRDYRNQQVRVLEIGVGGYKHPEWGGGSLRMWKSFFPRGQIYGLDIMDKSHVDELRIRTIQGDQNDAEFLDRIARRYGPFDIVIDDGSHINAHVRTSFAALFPHVRPGGLYVIEDMWTAYWPGFGGQADPQECSGTSLGLLKSLIDAIQHQELPSDPNRSPGYVDRNIVGLHVYHNVAFVEKGRNDEGGIPTWIPRDFESLVQASSGGAT
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFKNRKYAIIYTFLLILRFWFSQGSSYIHPDEHLQSFQIFANKLFGWKVELPWEFTTKKPIRSVVPLNVMLLPIFLLCRCICKSNCSPYPILLFTRLYMCLISLLIDLSIWNIVPLNARWSALLLYSSSFMATTFQTHTFTNSIETIFFFLTILFLSKLNSVPLNKKISYLYTFLLAIVSVLGFFTRITFLAFVIAPYIYFSVRCFKKNVNNPKDIFLHLCIFVSVSFATVLACILEDYKFYGVFVITFWNNLKYNSQIENLSQHGLHSRLTHFFTNMPLLCGPLIFVPKLWDVRKPATWLWLLPVFILSLFPHQEPRFLLPAASIFIVNSGCLVRSYWIKFLFVMYAVVLAVFFGIMHQNGVIPAVLEVKNIIEQRNVTTMENCNLYFNPEMPTTIYFWKIYSAPTWMLARPKFSQINTSHLYNYSTKQMISKFWETYYEEVKVVNLPEENTTEFQASTLLVCPVAMLQTSSYLQNLTMLHYIPYHVDLDDTDELPLAELIMNHGIGIFTAKEICENNTITNELPTVLRSVG
The following text describes a protein:
Function:
Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Plays a key role in the anchor cell/ventral uterine precursor cell (AC/VU) decision; required for VU fate. Regulates expression of lin-12/Notch receptor and putative ligand lag-2 in the presumptive AC and presumptive VU cells. Modulates expression of lag-2 in the gonadal distal tip cells (DTCs). Involved in formation of the polarised cell membrane of the AC and thus facilitates invasion across the gonadal basement membrane, acting via transcriptional modulation of multiple genes. Involved in specification of the hermaphrodite DTC and the male linker cell, perhaps acting in concert with the homeobox protein, ceh-22. Plays a role in regulation of migration of DTCs and the modulation of expression of alpha integrin ina-1 and ADAMTS protease gon-1. Required for DTC maintenance, and for function of the DTC as a niche for germline stem cells. Plays a role in cell-autonomously establishing a neuronal left-right asymmetry. Required for specification of cell fate, acting in concert with lin-32, in the development of the male-specific genital sensilla (simple sense organs) known as rays. Negatively modulates lifespan, perhaps acting by regulating expression of arginine kinases, which in turn results in altered metabolism and homeostasis of reactive oxygen species (ROS).
Subcellular Localization:
Nucleus.
Sequence:
MADPNSQLTSATTVATAAIAQPQVMLPNAYDYPYNIDPTTIQMPDYWSGYHLNPYPPMQTTDIDYSSAFLPTHPPTETPASVAAPTSATSDIKPIHATSSTSTTAPSTAPAPTSTTDVLELKPTTAPATNSAETSAIVAPQPLTNLTAPIDAMSSMYTWPQTYPGYLPPSEDNKASEAVNPYISIPPTYTFGADPSVADFSSYQQQLAGQPNGLGGDTNLVDYNHQFPPAGMSPHFDPNGYPGMTGMPPGSSASSVRNDKSASRATSRRRVQGPPSSGIPTRHSSSSRLSDNESMSDDKDTDRRSQNNARERVRVRDINSAFKELGRMCTQHNQNTERNQTKLGILHNAVSVITQLEEQVRQRNMNPKVMAGMKRKPDDDKMKMLDDNAPSAQFGHPRF
The following text describes a protein:
Function:
[GLV1p]: Signaling peptide (root growth factor) that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells. Also involved in the regulation of hypocotyl bending and root gravitropism in a PIN2-traffic dependent manner, thus influencing the formation of auxin gradients. Maintains the postembryonic root stem cell niche.
Miscellaneous:
MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
Subcellular Localization:
Endoplasmic reticulum. Note=The precursor is detected in the endoplasmic reticulum probably during its processing; [GLV1p]: Secreted.
Sequence:
MSCSLRSGLVIVFCFILLLLSSNVGCASAARRLRSHKHHHHKVASLDVFNGGERRRALGGVETGEEVVVMDYPQPHRKPPIHNEKS
The following text describes a protein:
Function:
tRNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in tRNAs at position 34 and 48. Trm4a and trm4b methylate different sets of tRNAs. Also methylates cytosine to m5C at positions (60, 61 and 62) in tRNA(Asp).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MGRKHYSSKKNRSKKGEFVNWDLIERKNENFEKYYRLQKLVTEDDFILLKQKLTEQLPTTFRITASIPHATQVRDYFIEHYYPLIENARTEDAKIPLPVSLPWYPDGMAFMLDISKEVIRKSPHLKALQEFLVLETEAGDINRQESVSMVPPLLLNVESHHKVLDMCAAPGSKTAQLLEALHKPTKKEDITTLLPSGIVIANDSDNKRAHMLVHQIKRLNSPNVLIVNHDASFLPNFHLSSPDGKKFLKFDRILADVPCSGDGTFRKNIALWNEWSLKTALGLHATQIKILMRGLQLLEKGGRLVYSTCSLNPIENEAVVSAVLNATRGSVRLVDVSSELPQLKRSQGVDNWVVCDSDLNIYPSFDTLPKELYEKMPPTLWPLPKKELAELNIQNCLRIYPHFQNTGGFFVAVLEKYENLTSSMKTAVDDNKVFLREQKLPSEQASKKRKQDTQETSSDSKLAEVKPKGKNGGNRFHELDPFVYIKEDDQALEKIYKKFGIDEAIIKKNQFFVRNVNGVPTKAIYISNDLFRNVIENNRNRVKFVHGGLKIFVRQDFGSLSREIAEKNGTCVFRVQSDGANLASHFIAESCLFHTTLSDLFILLDHEAVTIDDFPEDSLFRKEYNHLDLGSTLLHVDLAKEESVIKKQVYIPLWKSVRICNVLLSNSEKRTLKLQIEGPQSSIHKHNT
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MSFPKYKPSSLRTLPETLDPAEYNISPETRRAQAERLAIRAQLKREYLLQYNDPNRRGLIENPALLRWAYARTINVYPNFRPTPKNSLMGALCGFGPLIFIYYIIKTERDRKEKLIQEGKLDRTFHLSY
The following text describes a protein:
Function:
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety (By similarity). Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity.
Subcellular Localization:
Secreted. Note=Localized close to cell surface.
Sequence:
MLVLLLLVLLLAVPPRRTAELQLGLREPIGAVSPAFLSLTLDASLARDPRFVALLRHPKLHTLASGLSPGFLRFGGTSTDFLIFNPNKDSTWEEKVLSEFQAKDVCEAWPSFAVVPKLLLTQWPLQEKLLLAEHSWKKHKNTTITRSTLDILHTFASSSGFRLVFGLNALLRRAGLQWDSSNAKQLLGYCAQRSYNISWELGNEPNSFRKKSGICIDGFQLGRDFVHLRQLLSQHPLYRHAELYGLDVGQPRKHTQHLLRSFMKSGGKAIDSVTWHHYYVNGRSATREDFLSPEVLDSFATAIHDVLGIVEATVPGKKVWLGETGSAYGGGAPQLSNTYVAGFMWLDKLGLAARRGIDVVMRQVSFGAGSYHLVDAGFKPLPDYWLSLLYKRLVGTRVLQASVEQADARRPRVYLHCTNPRHPKYREGDVTLFALNLSNVTQSLQLPKQLWSKSVDQYLLLPHGKDSILSREVQLNGRLLQMVDDETLPALHEMALAPGSTLGLPAFSYGFYVIRNAKAIACI
The following text describes a protein:
Function:
Converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester using S-adenosyl-L-methionine as a cofactor. Involved in chloroplast-to-nucleus signaling by acting as a negative effector of nuclear photosynthetic gene expression.
Subcellular Localization:
Plastid, chloroplast membrane; Peripheral membrane protein. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Sequence:
MPFAPSLLSSSSSVSQFLPRFPNATRFNVTPRSRAATVVAASVTDLAGVDSTTIAVLGGGSVAALAAMVSLTDPERRRKLQAEEVGGGDKEVVREYFNSTGFERWRKIYGETDEVNRVQKDIRLGHAKTVENTMLMLTEDRSLAGVTVCDAGCGTGLLSIPLAKEGAIVSASDISAAMVAEAEMKAKAQLPSENLPKFEVNDLESLTGKYDTVVCLDVLIHYPQNKADGMIAHLASLAEKRVILSFAPKTFYYDILKRIGELFPGPSKATRAYLHSEADVERALGKVGWKISKRGLTTTQFYFSRLIEAVPM
The following text describes a protein:
Function:
Facilitates the assembly of the membrane proton channel of the chloroplastic F-type ATPase. Specifically required for the efficient assembly and integration of the CF(0) subunit c into the chloroplastic ATPase complex in the thylakoid membrane.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MAILSYISATSTTPPIPQDQSPNSRLPTKIILPNKKPEKWSTGVAPGEYGGPPTTTKLRKYWGGEKEDPITSTDLIWNRDFMDQMKKLFDDPNDSSLDPSPSKEKSSGFLSFSRVMSLDSMDVDLSKELASSSKSVVKNRLDTSKSEAKKQMSKAIVSPKWKLAPTRREQEKWDRATKAATGGSDVMFRELRRPRGDPEVQAAKDREQYFKLKNKIQVLTLGIGGVGLVSAYISYTPEIALSFGAGLLGSLAYMRMLGNSVDAMADGARGVAKGAANQPRLLVPVVLVMIFNRWNAILVPEYGFMHLELIPMLVGFFTYKIATFFQAIEEAISITTQKPESISPDTQASD
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes; Both IUM domains are necessary for efficient binding to ubiquitin.
Sequence:
MSWWSSTPSIDEQVEKATSESLPSGESDLALNLEICDLIRSKTVPAKDAMRSLKRRLLNRNPNVQLAALQLTDVCIKNGGSHFLVEIASREFVDPLMAIARNDDANPEVRQRVLQLLQQWAVAFAGQLQLQQVENAVTQLKSEGVSFPSASHDNAAVTSTFIDTKAPPEWIDSDVCMESGVAFSFLNRKHHCRNCGGVFTQACCQNYITLPHFGINVPVRVCNGCFKNLKKGKSDAPIHKPVPGATTTAPSSAPPANSAPNDDEDDIQKAIRLSLQEQESYKPPPPAAATSNDDDEDMKAAIAASLRDMENERQTGQTSASAGGLSSASTTVMAPSLTDLTATEESNINLLSLLVERLKGEPQGTILREPKIQELYDTVGNLRPKLARTMGETISKYDSLVDMHAKMTTVIRYYDALLEEKLNQAYTNRQSGGYAPQPHLSHQMTGQPPHLAPHLTGQITGQPHMGYQHTGQAPYLTGQVTGQAPYLSNQPTGHLTNHYTGSAPSAPQYGGPPAQNVYNAPSYQYSGAPEYDYASSPSAPSAPGGPSAPSAPAQPKEESAPLIEL
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVPEWEEAYMQYNHLKTILKEILIFRRLRQNQTSPPYQSPQKVILSERHSLYTAFSGLTNRVGNYNEENSSDTEEVILVTEIQHQEQCMHYQTMFFRSWEEGAENEIVFFKRLDDEFNKAICFYKRQVDEVVMEAEELNKQMDALFALKVRINDLNFHTSSTPPNSDPRNTRKKPNKDGFFRYSKSHKDQCHTRIRIITAWRTIFDGTKSDLSFNKRELRTAQAKLKQAFVEFHRKLRLLKSYCFLNQLAISKIMKKYDKVTSRNASKAYLEMVKNSYLSQSDEVVKLMDRVESAFITHFANANRSLGMKDLRPRAKKDKHGVTFFVGCFFGCLISLVVAVILTIRARDLLKSAAVPSNLEMEMDERTLSFTTLTELVPLGLFSVLLLIMICPLNIMYRASRFFLIVNLWHCVCAPLYKVTFPDFFLGDQLTSQVQLLRTVKFYICYYGWGDFKRRSNTCNQSSLYEFLNISIPIIPNMLANIMTFNWCDTLSTPQIKSP
The following text describes a protein:
Function:
Cell surface proteoglycan that bears heparan sulfate (By similarity). Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2. Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts. Promotes the axon guidance of D-type motor neurons.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cell surface. Cell junction. Cytoplasm. Note=Initially localizes to the ABar blastomere cell surface during interphase and prophase, and is internalized during metaphase and anaphase.
Domain:
The cytoplasmic domain is required for correct mitotic spindle orientation and internalization of sdn-1.
Sequence:
MILKLNFCLSTYSVLILLSLSTQAFAANQAKTKVVPSSTISTKSLKNGISEQVEGSANIPGRLADIEVNGSGYPTDDEDGDDVHGSGKPPSSATTKSDKVTSPSHAVVTAKPTTVPTTTASFKPPVQPKPKPAANDKEIKVEEDEDDDEDEDEDDEDDEEDFADENIHNDEDFFTTTTTTTYRPIVVATTSTPRSAATNPPRQQPPMVTSTISSGPFSPFHETLANGFYAAIAGGVLVAVITAILLVLFVVFRIRKKDEGSYALDEPKQARPYASYGYTKASTKEFYA
The following text describes a protein:
Function:
Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression.
Sequence:
MGLRVFCEIVESGSLTAAGNRLGMAPPMVSKHLARLERSLAARLLNRTSRSMSLTEAGRLFHEQAMQALEMLDAGVASVSQASGPPRGELKISAPVWIATPRFAALIAEYQQRCPEVRLDVHLENRMVDIVAEGFDLALRMKNDASQSLISRKLCEVQFYCVATPAFLARSATKSEAGAAQLPAMIMPNNLQFGRPKMPAQGMFLAPDQPVAMRSNDTTLSYHAVLAGIGAAFLPGWLVADDLASGRLVHSGEADKSYQGQLFAVYPSRRHQALKLRSFIDFLVENMDR
The following text describes a protein:
Function:
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAQSFSDYSMESESDSSKEETIYGTIRATAERPTGRLEDIQTNTMVIRIVIPDLQQTAAEYVPEKVKKAEKKLEDNPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEVKAKNDDKVEKLFQRCLMKVLHIDLWKCYVSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVCRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVEMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAGQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKTHSIYNRLLTIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDPRTRHHVYVTAALMEYYCSKDTSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRYTAFKEEYEGKETALLVDRYKFMDLYPCSTSELKALGYKDVSRAKLAALIPDPVIAPSIAPSLKDDVDRKPEYPKPDTSQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVILMKLLPPPICFQGPFVQVDEIMEILRRCKLPDTVEEAVRIITGSQAEMNMEGNGPVEVNTLLNKSVKRPNEDSDDEEEKGSVVPPVHDIYRTRQQKRIR
The following text describes a protein:
Function:
Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex.
Subcellular Localization:
Nucleus.
Sequence:
MRESLEGLSSLGFSVGQPEMAPQTEPGEGSHNSQEHMAPPQEEKALGTCSGCEAPRPEEGAPTEQAEAPSRGSRAYAPRKAEPMGSCPGDEWMIRKVKVEEEDQEAEEEAEWPQHLSLISSPFPAPDLGPLAATYKLEPGVPGTLGGLALAGWVPTSEKPYGCGECERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSHRGERPFPCSECDKRFSKKAHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCPECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTHKQHLVRHQRVHEAAGRSPPGPKPFSCSDCGLSFSWKKNPATHQGLHGSRGRPFGCDECALGATVDPAATEPLACAPRSAAAPEGAPTSERSFFCPDCGRGFAHGQHLARHRRVHTGERPFACAQCGRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAVHTGSRPHACAVCARRFSSKTNLVRHQAIHTGSRPFSCPQCGKSFSRKTHLVRHERIHGGAAHPASESDLSAPAWPTPTEVAAPTLLF
The following text describes a protein:
Function:
Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK also has postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.
Sequence:
MVSPTKMIIRSPLKETDTNLKHNNGIAASTTAAGHLNVFSNDNNCNNNNTTESFPKKRSLERLELQQQQHLHEKKRARIERARSIEGAVQVSKGTGLKNVEPRVTPKELLEWQTNWKKIMKRDSRIYFDITDDVEMNTYNKSKMDKRRDLLKRGFLTLGAQITQFFDTTVTIVITRRSVENIYLLKDTDILSRAKKNYMKVWSYEKAARFLKNLDVDLDHLSKTKSASLAAPTLSNLLHNEKLYGPTDRDPRTKRDDIHYFKYPHVYLYDLWQTWAPIITLEWKPQELTNLDELPYPILKIGSFGRCPFIGDRNYDESSYKRVVKRYSRDKANKKYALQLRALFQYHADTLLNTSSVNDQTKNLIFIPHTCNDSTKSFKKWMQEKAKNFEKTELKKTDDSAVQDVRNEHADQTDEKNSILLNETETKEPPLKEEKENKQSIAEESNKYPQRKELAATPKLNHPVLATFARQETEEVPDDLCTLKTKSRQAFEIKASGAHQSNDVATSFGNGLGPTRASVMSKNMKSLSRLMVDRKLGVKQTNGNNKNYTATIATTAETSKENRHRLDFNALKKDEAPSKETGKDSAVHLETNRKPQNFPKVATKSVSADSKVHNDIKITTTESPTASKKSTSTNVTLHFNAQTAQTAQPVKKETVKNSGYCENCRVKYESLEQHIVSEKHLSFAENDLNFEAIDSLIENLRFQI
The following text describes a protein:
Function:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MYTDALDSLLYLTAAALAAVIASVLLAFCVLMGVVAFFHPFADGGGGGERVLWCAVKAVHDASKTAKVVIYCREGLSAAALVEDAQRRFNIRIDKPIQVVPLRRVGLIQPERYPRLTLVRQALGSVALGWEALRQVVPEVYIDTTGWAFPYPLAWRAGAAVVAYVHYPTISSDMLAAVWAGSATAVSNDADIAESPIKTAAKLLYYGALAGWYAGCGAVTRLAAVNSSWTRRHIAGLWRLARRPPVLVYPPVDTAELQTLPLDRKLKQLYLVSVNQFRPEKNHRLQLEAFAAAKRSPAAAAPTLAGAALREARLKLVGGVRGPADEARLAGLKAYAAELGIADSCEWIVNAPFSELRQLLGGAVAGLHTMTDEHFGISVVEYMAAGCVPIAHNSAGPKMDIVLPLLLDAQGAAALAAAAGLGRGGSDSLGGCGGADGLLGPAADSPLVLDAGAHVSPAGAAGAGTCQAGGGGGGAVGGGAVQVTGFLATTVDEYAEAIIKVLTMDQRERLRVAAAAQRQAGRFSTERFLQDFTAALADVLPP
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MTQEMESIVMDHMGEEFNISVETLGKLVDVPKGFDTLHELGGVQGLAKALKTDLKQGLPAIETDLEIARVKKFSNNVLPPPPHQPLWSIVLDAMSDHILILLMVASVVSIVLGAVPYTSHDPKTGWIDGVAILVAVIIVVTITSINDFKNQARFRELNEKTNDKQVKAIRGGEQCQVSIFDVRVGDIVTLDTGDIICADGVFVEGHALKADESSITGESDPIKKGHPEDKVDPFLISGSLVIEGMGNMLVTAVGVHSFNGKTMMSLRVASEDTPLQKKLATLASRIGYFGMAAAILLLLIAIPKYFIEKKVKDEDINSDAASDIVSLVVCAITIVVVAVPEGLPLAVTMALAYGMMKMFKENNLVRNLASCETMGSATTICSDKTGTLTQNVMTVVTGTVCGNFPEVNESLKSKIPQHVAQILTDGIAINSNAYEGVSSKGKLEFIGSKTEVALLNFSKVLGSDYNEVRKRLEIKEMYPFSSARKRMNVLVKHTPTESRLYTKGASEIVLGLCDRYFDQNGNVIPLDASAKKYFEDQIMAFASDALRTIGIAYSEVKEGTEVKDAPENGSIFIGIVGIKDPLRPEVPDAVATCQKAGITVRMVTGDNIITARNIAKNCGILTEGGLVMEGPEFRKLSQSEMDAILPKLQVLARSSPTDKQLLVGRLKDLGEVVAVTGDGTNDGPALKLANVGFSMGISGTEVAIAASDVVLLDDNFASIVRAVLWGRNIYDAICKFLQFQLTVNVVAVTIAFFGTITYQESRDVEGRGPGSPLTAVQLLWVNLIMDTLAALALATEPPTPELLNRPPNGKNAPLISRSMWKNIIGHSAFQLAVLFTILYQGHNIFNHFIPESIERKQIDSDISLASSSSTSIDGDGKIIPEGSVHHYTLLFNTFVFMQLFNEINSRVLGSGTNPFKNFFNNPIFIVVMIFTLGVQILFVTFGSSATSTDSLYILEWVACIVVGAFSLPWGLFLRKIPIKEPVYKNEPPTVSEAIYTPPSTNIEMEGAHQNETAPVKLSKDYPTSAESTPNEEASPLVSRTSSVGAGDSTTPIPHNNVNKPTQVGRGWQIVRQTHKKLVVINALKEFNKDGETNLVDVVRGPQRGSISLPAPSNYANLNI
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNMDIAKPVGAEITRVDFGLYSPEEILQLSVTQITNPTTFDALGNPISGGLYDPKLGAFLRNNCATCNLDNRFCQGHPGHIELPMPVYNPLFFTQLWVLLRAACRFCGHFRTSKAEVHKIYCKLRLLQYGLVGAAAEIDNIKSFMKESDDDVVQDDASASVDAAVMDRQSKFTEKTIAEALKEGVTTPQGVQTATVLEERKFVIRDFYKLLVAKSQCAQCGMHSPAYRKDGISKIFEMPLSENKEKVNQSKGLRARNMIRDRSDPINEYPLPKAGANGRYLLSSEVRNILVTLFEHEQQLMSVLFRNRPNFDSQSISGDMFFLKNIVVPATRFRLPAARGEEVVESTTNTLLVKVLSTGMKIRDLNGTIAKMRLEKIGLPERKVTFAALMNAFVELQNDVNGFIDSTKGNQKTGSVPVPGIKQTLEKKEGLFRKNMMGKRVNYAARSVISPDPNIETNEIGVPPVFAVKLTYPEPVTPYNVAELSRAVINGPDVWPGAIQIQTEDGKMISLEGMTLEQRTATANQLLTPSANASGFTNKKVFRHIRNNDVVLMNRQPTLHKASMMGHRVRVLPKEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALLLANTDSQYLTPTSGKPLRGLIQDHISAGVLLTSKDTFFTRQEYQQLIYGCLRPEDGHTADVGRIHTVPPAVIKPVPLWTGKQVITTVLKNITPIGRPGLNLNAKNKVKNEYWGEGSTENSVIFQNGELVCGILDKSQYGAADYGLVHSIHEIYGAHIAGKLLSVLGRLFTRYVMNIGLTCGMDDLWLTAEGNNWRTTTLEGAKDVGVKAAAEVTNLPEDTDPEDPELLKRLEEILRDDNKLGILDAISQSKVNAVTTSVVSQCIPNGTMKRFPQNAMQRMALSGAKGSNVNVSQIMCGLGQQALEGRRVPVMVSGKTLPAFKPFETDAIAGGFVASRFFSGIRPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLIKQLEGVHSTYDNTVRDSDGALIQFMYGGDSVDVIKESHLQQFDFCVENFQAMVHKHQPGGNVDNLDTDTAIEYAKKAKKKAKKATSDAELPEPTISLYNPAKYLGSVSEEFSNSLEAYIASRPDVFPPKKSGKKSTYADQGVTEKKFRSLMQLKYMQSTVNPGEALGIIASQSIGEPSTQMTLNTFHFAGHGAANVTLGIPRMREIIMTASKSIMTPQMSLPVLPDVSDAEAETFCRSVQRVVLSEFVDYIEVTEKTRAETMTQGAARSFDVKMQFYTAKEYEEEYDVSPDMLKKRIALHYLNRIEKAVVKELRDQRVSKEVDGAITEVKETRSKAPSKASDEADDEDDDEDEDEAKEKRSTKQSVSYDEGEEEHKTAKDAVEGDSDSDSDSDSDSEGENVMSDTDDSDVEMADDEEEGEDDILSRYKTIKSFKFDKQGEWCTFTIMLPGDTKKLLMVNILEDLCRSQVVREIPNIGRCIFPKADSPKDRKLTTEGVNFREMWEQGEFIDVNAIYSNDIYAVLKTYGVEAARNTMVQEINNVFKTYAITVNLRHLELIADMMTREGTYLAFNRMGVDSNTSPFLKMSYETTCGFLTKAVLDGGCDALESPSARIVIGRLSGVGTGSFDVKAPIIEEPEE