lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A ssDNA-dependent ATPase with 3' to 5' helicase activity. Involved in multiple DNA-damage responses, some that require ATPase and helicase activity and some that are independent of these. Involved in DNA interstrand cross-link repair, probably together with Fancl and other Fanconi anemia pathway homologs. Independent of Fancl involved in DNA double strand break repair, including contributing to the synthesis-dependent strand annealing (SDSA) pathway. Probably contributes to SDSA by unwinding short duplex regions in complex D-loop-like DNA structures.
Subcellular Localization:
Nucleus.
Sequence:
MDVNWMDDDEDLVAALAMHEEQKSEDADGTRWEHCDEACDGFDMATGHNWIYPNNLPLRSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPLVSQQIHASQKIMPFPSEDTVQLTGQLPRPKRAELWASKRVFFATPQVVHSDMLEADGECSFPFGSIKLIVVDEAHRAKGRYAYTQVADCLMARNRYFRMLALSATPGRTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEPRERLLQIIEPYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHAMTNGEVPPLPSDLDFGHAKYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQGSTVGASYALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQPVAQTGSLRKYFKESPPTESQQGILQGIKPYQMSEASQQLVKQQVLRRSVTLKNFFGESQASSTLTSSQEDVQRLRKLTRLLQSSKPFVSDSKDLMSHLQDDHLPRQIKLYLLKSNPEFLRETHLKMQVQSELNIADDRLNSRQRRTKNNYQLLLDICDGMDQMNELLQGDNSGAEISFRDELNPIYNQSPKKFDTICEQIFDGLNEHGLNSNNFELKQDLLEKLELRNLETTVNEQLGGIEASWSEEEWDQQEEDVKFESMYLSQQLNLPDANVVPHSSTPLRVKPLSKLMFKTLQGDIEEEYHSGMEASELGDNLGRLNSLMNASESKIKATERIAPIPVVDSTIETNHFPAVEESQRSTPISIADSSGESNHCAVNKNSEIYPMSIDETKVEVKSSLNLKMHAESIVEDLDIDLDDFLEPMDKELELASQTKGKSQENIVDHQMEKLEKNCEQKETAHNNDLDLTDEDLKEFLEPMVEEVELMSQKKANDFKDFLEPMPEELELMSQQKKNILLPSTETIKNSENKNSHEDGSRTVSPDIFGSDSMSPLKPQGKSLAAKLAAKAAAKVLPCPPPNSVGLNSPENRKRTNPSIQEKSPSIFDLYLNRMRGRGRLAKAAENLHRITSTNPTISVPKDEEDSPIARRPSKRKIVISSDEEEEQKPQIAETQVDCESDDYERILDTQMPDPRKTPTRPRHKRSKFNSFILDEAEKSGSDHEEEGETTIGTYLKDSMIVSSDDEDHNDTNTHAIYLRALKSPIQRPGAFKMPPPRVFRDESHIFSQPVEDDSSQYMQCSFIVDDESSTIERGHDVSECPLEKAERILKERRKQRRLGKVPSAPVNKRRRLQTISTSSDEDDVVLID
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTGRKGSRSSEQLLAVAALLTLVYATKSASTAAITDADTGPAQITNVCKEEFYLSELRKEIAAGITRRRRQRQDLLKLERKYRLAATMATQPNDRCLYSALAAKLEQKAESVQQQADKADDTATTAMGLIDEHVGKLKYAQKLLKTKAAVDATGYSRAGDSSNIYLELTRETIGNGRCTAIDSWGKFSSAHTAIDAAKLTEIKITPDTDLATKIFKDKITITGFNGCTASAVAKTRTFSSVLSTCTVSGSEAVTYARNSADYSYSTSTAAFYKNHDPDQGCEDATAAGEEGATADIKLRYAVCLAVKTIQTDGGKVPPLSGKALKGDKLVTNILRNCLPAYQAVSKPWDSVEAKDLNDFIESAYGADDGKFKEIFDTPLDSRQITVKLNDKSEDKALTALATASERNAATSHSGGQRNKKEIETSKKQPAGAPVASKESEEICKDKAQKECKEEDRCVFKEEKCKVKVTTTTGKDGKTNTTGSNSFVINKAPLLLAFSLALLNF
The following text describes a protein:
Function:
Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. Stimulates the contraction of rectum and elevation of blood pressure.
Subcellular Localization:
Secreted.
Sequence:
MKHPFPQFPPILVIYCFCMLQIPSSGASPPLAGPPDGLDAVDPERLAHFLNQRETCSNQPKESRDVYKRFLFHYSRAWKSTHPVNSEFAPVHPLMRLAAKLPSRRMKRLPRLLHTDSRMATIDFPKKDPTTSLGRPFFLFRPRNGRYTDKVQ
The following text describes a protein:
Function:
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQPEEFTSSVTLHPPNASVTPAYLDFFNSTEWRLVFSIIPPYIFIVCLMGILGNSFVLLVFLLQRGRWSVPEIYLGNLALADLILLVCLPFWAMNILNYFMWLYGEFMCKVVNMSIMVNMYTSIYMLVMVNVDRYLALVLTMRARWLRRKRYAKLICVILWLFGLGMGAPTAAMRKLIDIPAHQSVECMLNYPNGNWRIAHLLQLNIVGFALPFLVITFCCFNIVRALKRRRDSGYWEDGNDRKATILVCAVTFLFFFCWGPFHFLTFLDLLCDLKVLDEKEWAHFLNIGNQFSVYLAFSNSCLNPVLYVCSGNYFRRKVSSIYKRRKQSSDATTLQRTALTSTTTTNQIKPVVLNEKD
The following text describes a protein:
Function:
Beta-trans-bergamotene synthase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2). Within the pathway, the membrane-bound fumagillin beta-trans-bergamotene synthase af520 converts farnesyl pyrophosphate (FPP) to beta-trans-bergamotene. The pathway begins with the conversion of FPP to beta-trans-bergamotene by af520. The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps. 5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene. The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin. Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (Probable).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDRVLSLGKLPISFLKTLYLFSKSDIPAATLPSMAVALVLAAPCSFHLIIKGFLWNQLHLLTFQVKNQIDGIDEDSIAKPHRPLPSGRITPGQATLLYRVLFFLMWVAAVYTNTISCTLVYSIAIVVYNEGGLAAIPVVKNLIGAIGLGCYCWGTTIIFDGGKELHGLKAVAVLMIVGIFATTGHAQDFRDRTADATRGRKTIPLLLSQPVARWSLATITAAWTIGLIALWKPPAIVTLAYVAASLRCLDGFLSSYDEKDDYVSYCWYGFWLLGSNILPIFPRLRGELP
The following text describes a protein:
Function:
N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.
Miscellaneous:
MISCELLANEOUS: [Isoform A]: Does not contain a signal sequence.
Subcellular Localization:
[Isoform C]: Secreted.
Sequence:
MTALGLVLLSMMGYSQHMQQANLGDGVATARLLSRSDWGARLPKSVEHFQGPAPYVIIHHSYMPAVCYSTPDCMKSMRDMQDFHQLERGWNDIGYSFGIGGDGMIYTGRGFNVIGAHAPKYNDKSVGIVLIGDWRTELPPKQMLDAAKNLIAFGVFKGYIDPAYKLLGHRQVRDTECPGGRLFAEISSWPHFTHINDTEGVSSTTAPVVPHVHPQAAAPQKPHQSPPAAPKV
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.
Subcellular Localization:
Nucleus.
Sequence:
MRINGCRFARLVTSQFHHVHKFDTSAAHRCLVHRTICHHARRPHARVEASLPTPNFELRRGARTRTTVKVKDLPQGTVKLKPYDDGATGATDDAPQYPTVVQGHRNNMRKFRNCVILTRVGGFYELYFEQAEELAPLLNLKLAVKRTSAGPVPMAGFPFFQLDRFLKILVQDLNKYVAISEEFANAAEDKARGGLLFDRRVARIITPGTLIDEKFMDPSENNFLLAVYIDVAALKAQLEQQEGNLSAQQHILSSASQHVGLSWLDLSTGDFFTQSTTTQMLPSAIARIGAREILVDQKLQDLIGQELQLLVGHDHRLMTFFAYPSKILPIAQWSSVLEAQVADQDSDAFTPEEVAAGYSLLEYIRVQLQGLNLKLQPPRRRHLNESMNIDRNSLKGLEILETARDGFGKGSLLHAVRRTSTKSGARLLRDRLTSPSTSLLVINERLDLVSVFLENSDLRDSVIQLLKRSYDAQRLVQKFTLGRGDADDLICLARAIQASREIKMVLSSQDNGPLEALPHIQSNHAKRSLSAMTGRLCLDGPTALADRISAAIDEEGLLQKQRLADDTAAEAAILAQEVAMSEGLPGEVETLPKKVRAKNSDQSKTSTEEITAPDTWIMRRNASAALLELHESLDRLQDEKARLTQRLREAVGSSALSLRWTSGLGYICHVKGAKISQQSLEELGVTRNVSSTKSTRSFYLPAWTALGDRMDQVKVQIRQEEQAIFETLRREVILNLVKIRRNAAVMDELDVACSFATLAEEQRLVRPILTSGVTHKIVGGRHPTVKLGLEEQGRQFVSNDCFLGDSERIWLITGPNMAGKSTFLRQNALITILAQVGSFVPAEYAEIGIVDQIFSRIGAADDLFRDQSTFMVEMLETATILKQATARSFVIMDEVGRGTTPEDGTAVSFACLHHLHYRNKCRTLFATHFHALADMTDDFEALGRYCTDVKESASGSFSFVHRLRKGVNRNSHALKVAQLAGLPKETLEMASRVRESLGNRAPWSSGGSDSHPIVSATV
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLPDPTVLLIIGAVIAFILAFAIGANDTANSFGTSVGSKVLTLHQAYVLASIFETLGACLLGHQVTDTMRKGVIDFSEFGKHENGTVLMSENDLGHTIMLGQIAILTGCGVWMLLATAFKLPVSTTHSIVGATIGFALVAQGSRVIVWEKIYRIFFSWIISPLLSGIVSVFIYLSLDHLVLRREQPLHSGIRVLPALYFICFAFNVFAIVYKGPSFLYFDRLSLTQCLIISGVFGLAVALIFAFFLAPYLKDHILSKELLEITGKQRHSHHGHNEKSSSKRKEFEMEEGNGKYLESDNNGQPLLDQPTIVVSTCPSNGESTSSFAKNTIRPSSSLASFFRSCKPEDPQASRLFSLLQVMTACFGGFAHGGNDVSNAIAPLVSLYLIANDGMKSADMETPWYLLLYGSFGMCLGLWVLGHRVIYTVGENLTKITPASGFAVEFGAAVTVLIASKLGLPISSTQCKVGSVVAVGLVQSRHQVHWGVFRNISLSWIVTLPVAGLLSGGTMMILHLFSFGTDATPKDSILQLFF
The following text describes a protein:
Function:
Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT3. Does not possess detectable glycerophosphoinositol (GroPIns) transport activity. The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism. This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATRDLPHSVGDFCFGWVDQIRSEITLGKSQDQLIKEDVLEDDETVETKVEIKNLWPAFASGAGLFSDGYVNAGISTVLSCLKKIYGDEFTKSNAMNNIGSIGFVGTVVGQLSFGYISDNFDRKTGMLTANVMLIFFTLMCAVASWGTTVQGFFACLTVWRFFLGIAIGAEYPTSSVIASEFANQLPSGHRNRYFSWFTNAMIDFGFVVSSFVPLVLLWIFTPRHLRAVWRLSIGLGVIPPLILFFIRLKMDNSKSFKKMNMKRVNYSKYPWWLIIKFYWFRLTVVSLIWFIYDFSVYSFGTFNTIIIGEVIPNGTLYENWGWSVVFNLFYMPGAFLGAFIGDYLGPRLTLAIGVGAQGIIGIAMSACLKSLKKHVAGFVVVFGIFSTFGEFGPGNNTGLLASKTCASSIRGQYYGIAAAIGKIGAFVGTWVFPAIQKHYAYSEDLSLQVPFYVSSALCLFSAFLTIFFVPPVGQDAINKEDRLFKEYLEENGVDIRLLGDSGVVTQYQEDEDIGVISDEKDDTVKVQQKNV
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MALQQAAPRVFGLLGRAPVALGQSGILTGSSGFKNQGFNGSLQSVENHVYAQAFSTSSQEEQAAPSIQGASGMKLPGMAGSMLLGKSRSGLRTGSMVPFAAQQAMNMSTAAQVQSGATVNSLLLGIYRFWRSQAPMDKPHAPVDDRMLPAIVDASDNRAALGTWATALFCTILASNLLGLVPTNEAPTSGLGFATGLGVSVWATATTLGLYKLGFSFPGHFIPGGTPWPMAFIFVPLETISYTFRAVSLGVRLWVNMLAGHTLLHILTGMALALPFSLSFFAMVPATFAVACLLSALVGLEYLVAVLQSGVFSILSTVYVGEFNSVKLAGPLAKVVKKAL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLVLDLDQTLVSVADHDEETLLRCVTKRPGLDRFLKDMSQVYEIVIFSASGASYVKKIVSSLDPTGEIFSAVFTGSDTDWLSGQRVKDLRKLNRDKIVWIDDNASLYPYNPKNGIQVPPFHGDPNDSILGALTPLLLEVALGQISVENASELFVRARNK
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MYSTLQRANHISSLATTYILILLGLISVASFLSLPSVDLGSIDVKDIIVTRGRLNRWGAKQEDIASLRFDVRTNLNELLNSYNTKQLFLYLTAIYEEESTGNAHEVVLWDRIVTRADTRDIRAVGRELPKSNRKKGRGNVRVEDGKNKYIWRNPSGTFKDIPYANLTLHYSLMPYVGYLTSGIAATAEGPVSIPEVIKR
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MGFNDCIKSCRLSPQHEGSFRMKIYERDDFRGQMMEFTEDCPNVYERFNFQDINSCQVLDGYWIFYEEPNYRGRQYYLRPGEYRRYNDWGAMNPRTGSFRRIYHHY
The following text describes a protein:
Function:
Hydrolyzes carboxymethylcellulose.
Miscellaneous:
MISCELLANEOUS: The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when DgcC, a putative transmembrane protein regulated by CsgD, is expressed. Cellulose production is abolished in E.coli K12.
Subcellular Localization:
Secreted.
Sequence:
MNVLRSGIVTMLLLAAFSVQAACTWPAWEQFKKDYISQEGRVIDPSDARKITTSEGQSYGMFSALAANDRAAFDNILDWTQNNLAQGSLKERLPAWLWGKKENSKWEVLDSNSASDGDVWMAWSLLEAGRLWKEQRYTDIGSALLKRIAREEVVTVPGLGSMLLPGKVGFAEDNSWRFNPSYLPPTLAQYFTRFGAPWTTLRETNQRLLLETAPKGFSPDWVRYEKDKGWQLKAEKTLISSYDAIRVYMWVGMMPDSDPQKARMLNRFKPMATFTEKNGYPPEKVDVATGKAQGKGPVGFSAAMLPFLQNRDAQAVQRQRVADNFPGSDAYYNYVLTLFGQGWDQHRFRFSTKGELLPDWGQECANSH
The following text describes a protein:
Function:
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).
Subcellular Localization:
Cytoplasm. Lysosome.
Sequence:
MEAPLVKCLDEILDSGAVGVICADKDGLALHSAGQVQLRAAGVITALASLAKQIDPSCDTTPTIHLESDSLDVYIQQKEQVSLAVYSTPKK
The following text describes a protein:
Function:
Required for developmental progression after cells of opposite mating types fuse with one another, essential for processes common to both dikaryotic filament formation and monokaryotic fruiting. A direct target for transcription factors Sxi1-alpha and Sxi2-a.
Sequence:
MATYLAPPVSSNKENSPAPNIALSDIDAISLSLRTSLSGVTLPAKKKVAALGLGRAPKFTYRRHSNKPYNRSTSITRAKKAAVQTKSVRSKAAVKKSNTRPLPLKLVQRLDVESARLERLRKAVWNPPAPVPGQVRVPLKLPYPRFPSIEYIDNEYLKEIPVQYIFDRMVPLLPSIATITLAYQPYASIPHPDSKILRDTTLAFAIPEVIDGRKPHWAAKARGREPDLALAVAYKSGEGSNGNTVVAVNSLAFATQCAYWPRLLTTSIPIPTPKRPTPSASAVSTSLPAIVETEENVSDASFSSSSSWSDSDSEVEFIDLPRLPRPVKDDKGFLHLPLVELPIPSPSTFPIIHRHLHHPSRALLPDLLGLPEHYTTRSQVLDAISGLSVQQLMDKLTTLQGVWQNLCSLGIGRLGTWRQLGEAWACVVGVIAGQGLLIAGQEEAEVQRTGRKTAAEDVAWEWVRREKAKEQQ
The following text describes a protein:
Function:
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSRAALDKDPRDVASMFDGVARKYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAAGTAVSTVELTKSGAWCVAADFSVGMLAAGAARKVPKVAGDATRLPFGDDVFDAVTISFGLRNVANQQAALREMARVTRPGGRLLVCEFSTPTNALFATAYKEYLMRALPRVARAVSSNPEAYEYLAESIRAWPDQAVLAHQISRAGWSGVRWRNLTGGIVALHAGYKPGKQTPQ
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPNCSCATGGSSTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MFDLNQLRCFVTVAEELHFGRAAARLNMTQPPLSRQIQVLEHIIDAPLLERTSRSVRLTPAGRSFLPEARRILKLAESASQVARRIALGKTGSLKIGFTAAAAYGFLPELVAACRAKLPEVDFSLKEMVSGDQFEALSSGQIDAGLLRPPIARPEVASRRVVAEPLLAAIPKKHPLASADSITIKDFDDQPFVMYSPYESRYFHDLLVALFTRADVLPRYVQHLSQIHSILAMVRAGLGLAIVPAAAASLKISDVRLRPLKLRTRVPVELFMVWRRDDENPLLSALVKIAGELSSAETMED
The following text describes a protein:
Function:
VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
Subcellular Localization:
Secreted.
Sequence:
METRRKPQLLMSLIVLSVLFSQTSAWPLFEAPSLRIPFEGANELDRVSLKPDTDILQNAFAENDSYFHSTALQVSMGRGFIQSDVLQLLQLHMILMNARHADGVFTSDFSRLLGQLSAKKYLESLIGKRVGNNISDDQGPIKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSAGTALAHILEQLWSVEANALGSLFPVTSDLTVYPHRDPETHLGFDNEAWAYAYENEVEENRERNHSELTPRQSIRSARTSFAQAGPVLTRF
The following text describes a protein:
Function:
Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
Subcellular Localization:
Cell projection. Cytoplasm, cytoskeleton.
Sequence:
MAGRGEIVEAESAEAEAIITRIEHKTRKIESLLKQGRPVEALKTALEGSPPKTRDERCKSANWIVVHRALMAIKDVDSLFSALDPEYYDILMKYLYRGLSTGDRPTCDQCLRIHEKLTEKAGLGCILRSLADTVNTV
The following text describes a protein:
Function:
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRKSLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVICPGCSIPLTIVKSDGGYTYDTSDLAEKADMIIYVVDNGQVSLQYLAAAQMIVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence at the MNF1-binding site.
Subcellular Localization:
Nucleus.
Sequence:
MQEASSAAAAGAEPGRRAAQHQFAGVDLRRPKGYAAPAPAPAVGEGDPCPRCASRDTKFCYYNNYNTSQPRHFCKGCRRYWTKGGTLRNVPVGGGTRKKPSSSSSSSSYVAAADADRQPKKKPASKKRRVVAPAPELATAADPGKTATTTTTTSEITTETGALEDSDSLAHLLLQPGTEDAEAVALGLGLSDFPSAGKAVLDDEDSFVWPAASFDMGACWAGAGFADPDPACIFLNLP
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MRPFHVRGTDRAIMTVKINYDGDLFFTASQDGGINCWLTETGERLGNYKASGAVKTLDLTDNSELLVSGSLEGSVDFFQINGGKKRPNGLSFSFGDENLIIVYQPMTSTINYETRILKVQEILDKIKLRQTQDVLEITDTLITPDKFKTTQASWGYLNQTIVMASTEGELLLLSYPQKQEIRRVQVHDGEIKQFTFAKDFSILATAGNDGCKIFDPATLQLLRQFKYEVPMNAVAISPLFNTEQKPKPHLIVAGGIPARETARTKFQGFDIHICNVIYEEEVGKLLNPNQIGPINALAFFPDGKGFITGEEGGYSRVYKFDQTYWENDLFK
The following text describes a protein:
Function:
Required for male gametophyte (pollen) development.
Subcellular Localization:
Nucleus.
Sequence:
MNGEISRPPELISSRNPCKSFENAIHKAVEAELAELAKSDANGGGKSKVKGPWLPEQDEALTRLVKMCGPRNWNLISRGIPGRSGKSCRLRWCNQLDPILKRKPFSDEEEHMIMSAQAVLGNKWSVIAKLLPGRTDNAIKNHWNSNLRRKPAEQWKIPLLMSNTEIVYQLYPSMVRRISNASPKEHLPQEEETGVLSDDKMDDEAKEPPREQNSKTGVYRPVARMGAFSVCKPGYMAPCEGPLVQASRPDSLAGKFLQSLCYDPIIPSKCGHGCCNHQDSTTLSSSSVLGSEFVDYEEHSSAELDKELISISNDLNNTAWIRSGKEAEQSLKADDQFRREYAHSKFSGMVNNGVSSQMVRQDLRALS
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS).
Subcellular Localization:
Nucleus.
Sequence:
MDPSLPPDPNPAETEPSADVTPPADTDQDSPINPLVDPQPCDTPISDLVHEPAAPAEPTPAQGLKPELPAPELTTQNLIPGPAPAPPPGANFNKIMTFRPTMEEFKDFGKYIAYMETQGAHVAGLAKVIPPKEWKPRRSYETIEDMVIPAPIMQVVTGQSGLFTQYNIQKKSMTVGEYRKLANSKKYNTPQHKDFDDLERKYWKNLTFVSPIYGADISGSLYDPDISEWNIGHLNTLLDMVEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGKPKSWYAIPPEHGKRLERLAQGFFPGSSQGCDAFLRHKMTLISPSILKKYSIPFDRITQEEGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKMAAQCTCRKDMVKISMDVFVRRLQPERYTQWKQGKDTMVLDHLKPTSLSSPELEHWRKNRVTFREKVLRRAQAKMKQFRRLKPEDLKVLMEAGVELDMEEYQRKVEEHDEQRRQQRDERMAREAMLTLEALEREEQEQAEAALRGGGVEEIKADFQDPPVENGEKKKKKKKKLQLTDEMSFQEVFEQFTTASEMQNQSNGAAPLQTNPFTKLKKKVEVKKSRRHPISKPPMRSPHSIVKQEASSDEELYSGLPVGGGVTHESKKPEDSDLWQNRSPNFLAEKQFNAAMSTIEPYCAICTLFCPYTQSVKDPFHISDMSGLVSRVGCRTRPLVPEMCFSAGAENMEPLSSNSHIADDGTSVLLSCSGCNLQVHASCYGVNPQTKQEGWMCSRCTTVAWTAACCLCSLRGGALKKTTDERWVHVICAIAVAEVRFVNAIEREPVDVTAVPETRKSLKCVYCHKTTKQIFGACIQCSQDNCSTSFHVTCALLAGVVMKPADWPYVVSVTCHKHKLTNQKAKSGSRDLSLGQEVIGRNSNGWFYRCVITGTGTQTYYEVNFDDGSYCDNIFPENLLSHDCLRNGPPELGELVVVKTVDGRVLNASYIKEHVHRYYQVEFQDETQLLLKRSEIHSLDQELPKRVMSRLATVNQQQPQAQPSDEPLAAKRPRLPTPPPTLAIEPSALPPELVSTFLPPSITANTSTAPCLPPAALPVSAPPEPSESYTHSSSYIAYMESLLKSDFPAEDGEPGLEPMY
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MPEILNHTLILEKIKNLGASPGCYLWKSKKGEVLYVGKAKNLDKRVRSYLKENHPDVKTKVLQREIFDLDWIATGTEKEALILEATLIKKHNPRFNVRLKDDKKYPYICVSLSEPYPMVYVTRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQVLPLPRPRRPCLNFDMGRCLGPCQGNIPVEDYKVIIDQVIQFLEGRKESLVSDLNIKMSNASERLDFEKAARYRDMLQRIQNFREKQTVVSLEGGDEDVIGFARKQDEGQVILLEIRGGRLETKKSFPIQGVLDAENSEILGAFFRDYYLNASLVPPCIFIPADIQDEVIPVIDVLQEKTGFRPKIKFPKGGDKRSLLKIAEKNAELGLSERLLATHYRDQTASLKEIQEMFSLERLPHIIECYDISHFQGSQPVASGVMFVEGKPFKQGYRKYNIQGYEGINDPGMIHEVISRRLQRIINEEGVFPDLIVIDGGLTQLTKACEAAVEAGAEGIPMVGLAKKREEIFFPGENEPFIFDMNSPGMKLLRHLRDEAHRFGVSHHRSRRNKETMRSLIQEVPDIGFKRSKLLLQHFSGEKKIEEATKEELLLVPGIGENLAEKILKQLQKKE
The following text describes a protein:
Function:
Exhibits a dual-cofactor specificity, with a marked preference for NADP(+) over NAD(+).
Subcellular Localization:
Cytoplasm.
Sequence:
MKAVAINGYGTVGKRVADAIAQQDDMKVIGVSKTRPDFEARMALKKGYDLYVAIPERVKLFEKAGIEVAGTVDDMLDEADIVIDCTPEGIGAKNLKMYKEKGIKAIFQGGEKHEDIGLSFNSLSNYEESYGKDYTRVVSCNTTGLCRTLKPLHDSFGIKKVRAVIVRRGADPAQVSKGPINAIIPNPPKLPSHHGPDVKTVLDINIDTMAVIVPTTLMHQHNVMVEVEETPTVDDIIDVFEDTPRVILISAEDGLTSTAEIMEYAKELGRSRNDLFEIPVWRESITVVDNEIYYMQAVHQESDIVPENVDAVRAILEMEEDKYKSINKTNKAMNILQ