lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MAGAIFWAAWRPLWPSRYCWAERWWLYAVRASTFLEISTETSKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLLRLRKQAEKNVEKKICKFTEVLKTNGLLV
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MFPATTTAAPPSPPPHFFFSTPPPSLSSLLFSDLLLRPPCSPTTPSLSFHRSLNFTPFLPIAVKVASRSRCFPKSTAEDQLSDSDTRDAGDIDFEEKDDSGNAKIDHYSGDDIRKENTPPPSTLGIPEPVYQVVEVNSDGMISTKTINRRNLLKTSGLRPRDIRSVDPSLWLTNSMPSLLVREHAILLNLGSLRAIVMQERVLIFNYNRRGGKAFIDSLLPRLNSENTNGVLSLPFVLEVVEAALVSRIQRYEQRMMEVEPRVQSLLEVLPNRLTGDMLEQLRTSKQTLVELGSRAGDLRQMLLDLLEDTDELGRICIMGRNCTINRITHSLECSVPLDKEIAEEEEEEIEMLLENYLQRCESVHGQAERLLDSAKEMEDSIAVNLSSRRLEVSKVELLLQVGTFCVAIGALIAGIFGMNLRSYLEEHVFAFWTTTAGIMIGIVIGFFLMYAYLKKRKIL
The following text describes a protein:
Function:
May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MPAVAVLAAAAAAWCLLQVESRHLDALARGAGPNHGHFLDNDQWLSTVSQYDRDKYWNRFRDDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGSVAHKHWAGPANLVKCKPCPVAQSVMVCGSDGHSYTSKCKLEFHACSTGKSLTALCDGPCPCLPEPEPPKHKAEKNACTDKELRNLASRLKDWFGALHEDANRVIKPTSSDTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEDERELGPQDTEGKLRVHSRAVAEDDEDEDDDKEDEIGSLW
The following text describes a protein:
Function:
Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (By similarity). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein. Nucleus.
Sequence:
METSSPRAGSQPAPTAARYFASCRAEPLRVSSRDQLAEMAAASQGNFEGNFESLDLAELAKKQPWWRKLFGQESGPSAEKYSVATQLLIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVKSKAEEVVSFVKKNVLVTGGFFGGFLLGMAS
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
MRGNIGYLGLIIFGLLAFISSTEAQLQMNFYAKSCPKAEKIVSDFVNEHIHNAPSLTASFIRMHFHDCFVRGGPSWQVPTGIRDGVISRSSEATAIPAPFANITTLQTLFANQGLDLKDLVLLSGAHTIGMAHCSTISDRLSPDDTTTKIEMDPGSRKTFDLSYYSLLLKRRGLFESDAALTTNSVSLSFINQILKGSLQDFFAEYANSMEKMGRINVKTGSDGEIRKHCAVVN
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MASEEGKKMITLKSMDGQEFQVEKEACAISEMIKFVSDDCDTEDVIPVANIRGNILAKVVEYMKKHLEFASKKRSSDAGKEIAEGNEELVDVDEEIKAWNNDFIKDVDTDTLYFLLIASDYLSIKGLLDLGVKKAADLIRGKSPEQIRTTFNIQNDFTPEEEAEFRKEYSWVFDEGI
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MSEKQAKEPYGGSALSELTNIPDVPSTDGKKPEEEKFDLGLDEEVVIKKERKPRIKLDEDYLLSENGIPRLRKTAPSLRFKGKNHEAQDMKRLLAFYQLWAHEMFPKAKFDDTIIGLQSLGKRRMMKIHRRHWIEEYSNPHRDEDLFADLLEDEAQHKSKDATGSKQSEYVQTADDENFVVRDPDDELMG
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MEKDVYGEEAWQSINKNFDHVKGLYLDHAGSTLYSKSIIENSLTELTQNCFGNPHSRNIPSKITSDLIDQTRIELLNFFQADPDQYAVIFTSGATDSLRLVAESFKFSNDPDVGECGSFVYIKESHTSVIGMREYFKSFVPCYALPCDEITTYLNPGSATIPNAEHKKSNFLSSNTDENKVSHDEKCSANQHEKFEPSSNSLFVFPAQCNFSGFKYPLELIAFAQENGFSEMKSDLCLNRELIRKQKKKNNWFCLLDAASFVGTNQLNLSVWKPDMVVISFYKIFGYPTGLGALIVHRRANCVLQKKYVGGGTVDVVSSSRDFHAARQLLEEKFENGTINFLAILSLRHGMRELKRLVTTMENVSIHTFQLGQLLYVTLRKLKYANGKSLVKIYSHTEFTDRHRQGAIVTFNLMTEKGDYIGYAHVEKILALYDIHVRTGCFCNPAACQKFLDLSEEDLCSNYLSGHKCGDENDLIDGRPTGAVRVSFGYMSQGNDVVQFVNILRQCQCEKVEMKPEQLVSSQPNIELSGICIYPIKSCGAFSPKAWPISKSGLLYDRCWVIVNEAGAALTQKREPKLCMIRPEIDLKEKKLILKCLTQPSITMDIEDYNLSATNELKFTKICGRVMRFAECESVVNEWLSKVIGQPALKLLRCFESHSSLVNDSSFLLVNLNSVSSLQMQFRNDDSSAPISTVTNEELVTRFRGNFVISGANAFEEDSWTKIKIGPFAFKNVGPCYRCQMVCVDQNTASRNQEALSVLANFRGKKMPFGICLEMSSQSNGSVVEIGSRIVRDYTEDSTI
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQVYILHIRIYIIEGNKNLKYRQYLIFLIYIPIIYQVTLVGNGAILLAIGTEKKLHTPMYYFLANLALLDIFCPSTTLYFLVALVGTEVFLLSVMAYDRYVAICFPLRYTLIITKVCCVQLTVGTWTAGFLNSLLHTVSTFCLSFCKYNLVNQYYCDIPPVVALSCSSTYVAEMLILVEAGILGISAFLVTFISYFYIISTVLKIQSMKGKCKAFSTYASHLLVICLFGGTMIFTYVRPYSSQHSPGIDRLISMLYGIVTPMLNPMIYSLRNTEVKGAVRRVLCHRTYLLQV
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Sequence:
MLMIVALTQHDNHQSTSSQNSTLKPFQLTFTQGFIVGQLSFLVLVICFVRYVVFEDPKSSQNKKPMGSQRKAYNHNPTVRRTSKQSRKLSFHDKSHGTAESELLSKLPYDLSSHPPETTDWLNVLLAQAIIAYRSLVHGLDDDPTMPKGNKAKEMVEEAMNFARGESPGIISVDYITVTEVEFGKEYPVCTNARVRPADETGRMRIEIDIDYSDRVTLAIETKVVVNFPTARFAVLPISLGLTLNQLSATIMAEIPPIAIPLPMNDDPSAPSPAILMSLDPDFTLSMTTTSLLGSRAKLQDIPKIEQLILGRLRGWIVDNLVWPKVRVLKLPGLGNKGSVEDAADGEGEYVWVEGTTKEKNSTSKESKPKSIIREADEDEGPSSSATSCEPPRGLSHSTLGLSAGIPLNPKYHRSTASGSSSRAANIPLLSPSELTELASRQRHPSTRTDTRQQAPPDSDGYSSHPKPPGGLPNSARSIGSFPESPLPPTLSQDHLKNSVTHHEWLNYPRSPDTPTSASNRLAEDRGRWARAGGMSGVPLGLGGSQTPNLGYGIRERIREAERLKGLRANDLDDSFTSQR
The following text describes a protein:
Function:
Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRYTLTYTGSVLGTTALTILALYYVLTGKGEQISFAWFLENVSPYMWASTGIGFAVSLSVVGAAGGIHTTGVSIVGAGVKAPRIKTKNLISIIFCEAVAIYGLITAIVLSSNFQVMTSAVKPADNLLGAYIIFAAGVTVGWVNLFCGLCVGVVGSGAAIADAANASLFVKILIIEIFGSAIGLFGLIVGVYLTSKGSMG
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MASAGGGALSILEYFGGEDGNRCGYCKSEASSMSHGMWAHTLTVQDYQDLIDRGWRRSGKYVYKPLMNQTCCPQYTIRLSASNFQPTKSHKKVLKKVLKYLHAGEVSHSKDEGTSGEPMDSQADSPVSCNVSIPDKSEIPEEELKPLNIEQEETVEDGESDKQEATRASSLCDRQEHCIQNAEVETHSHSNPKPGQGVDVTKPPCRKAKDIRKERRMQKHPSTNPACKAKGNCSKSVEEFISPPENSAHHLEVKLVPVSMEDPEFVSSFDRSAALYAKYQIAIHKDLPYKCSPAEFTRFLCDSPLELETRPDGPACGYGSFHQQYWLDGKIIAVGVIDILPYCVSSVYLYYDPDYAFLSPGVYSALREIAFTRELQKRAADLRYYYMGFYIYSCPKMRYKGQYKPSDLLCPETYLWTPIEECLPLLERSKYTRFNSNPKEGDKDMLTELGRVRVLYKRTVMPFSRYKKRHKGPNDEAAVRQYAGLVGQTCAERMLLYRS
The following text describes a protein:
Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MNGPADGEVDYKKKYRNLKRKLKFLIYEHECFQEELRKAQRKLLKVSRDKSFLLDRLLQYENVDEDSSDSDATASSDNSETEGTPKLSDTPAPKRKRSPPLGGAPSPSSLSLPPSTGFPLQASRAPSPYLSSLASPTYPPFPSDYLALQLPEPSPLRPKREKRPRLPRKLKMAVGPPDCPVGGPLTFPGRGSGAGVGAALAPLPPPKMPPPTILSAVPRQMFSDAGSGDDALDGDDDLVIDIPE
The following text describes a protein:
Function:
Potassium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDRQTGRHDSAATQSDATVVVSVHDGDTINNCHDQKDTGRWGNLVLAYKTLGVVFGGLVTSPLYVYPSMPLKSPTEDDYLGIYSIMFWTLSLIGVVKYATIALRADDQGEGGTFALYSLLCRNINIGILSSKSASLSSSHSYVNQSKKPSKLGKFCERSLIARRVLLFIAMLGMCMLIGDGILTPAISVLSAMDGLRARFPSVGKSLVEALSAIVLIVLFLMQKFGTSRVSFLFSPIMGAWTLTTPLVGIYSILKHYPSIFKAISPHYIVHFFLRNGKQGWIYLGGTVLCITGSEAMFADLGHFNRSSIRIAFLFTIYPSLVLTYAGQTAYLIRNPNDHFDGFYKFIPSAVYWPIFVIATLAAIVASQSLISATFSVIKQSVVLDYFPRVKVVHTSSSKEGEVYSPEVNYILMILCVAVILIFGDGQDIGNAFGVVVSMVMLITTILLSLVMIIIWRTPLALVALYFIVFFVMESVYVSAIFTKIPEGGWIPFAISLILAFIMFGWFYGRQRKLEYELTHKIDSERLRTMLMDPGLQRVPGLCFFYTNIQDGLTPILGHYIKNMRSLHKVTVFTTLRYLLVPKVAAGERIVVSKLGLKGVYRCVIRYGYADKLSLEGDDLVNQVVESLRAHLLQRSNHNSTEEEDEISELEEAKLAGVVHIRGKTRFYIGKHCGWFDRTMLVFYEVLHSNCRSALPALGVPLPQRIEVGMLYEA
The following text describes a protein:
Function:
Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cytoplasm. Cell projection, cilium membrane. Nucleus. Note=Primarily localizes to the cell membrane. Detected in the cilium of primary chondrocytes. Highly expressed at areas of cell-cell contact and may localize to tight junctions. Also found in the nucleus where it is detected in the soluble (as opposed to chromatin-bound) fraction.
Domain:
The RGD motif is involved in integrin ITGAV:ITGB3 binding.
Sequence:
MELRAWVLLWRLVLLQSSAVLLSSGPSGPATSDRSVVSESTVSWAAGARAVLRCQSPRMVWTQDRLHDRQRVVHWDLSGSKAGGPARRLVDMYSTGEQRVGEQRLGEQRVGEQRVYEPRDRGRLLLPPSAFHDGNFSLFIRAVEETDEGLYTCNLHHHYCHLYESLAVSLEVTDDPRAAGAHWDGEKEVLAVERGAPALLTCVNRAHVWTDRHLEEAQQVVHWDRQPPGVPHDRADRLLDLYASGERRAYGPPFLRDRVAVEADAFARGDFSLLIDPVEPADEGTYSCHLHHHYCGLHERRVFHLRVTEPAARPPPPPRDSPGNGSSHSGAPGPGARDPTLTRGRSVINVIVPEGRAHFFQQLGYVLATLLLFILLLITVVLATRQRRRGGYEYSNKKSKSKGKDINMAEFAVASGDQSLYRSEDIRLDYKNNILKERAEVAHSLPPAKNIDLDKEFRKEYCK
The following text describes a protein:
Function:
May have a role in cell wall processes. Does not exhibit cutinase activity.
Miscellaneous:
MISCELLANEOUS: A single nucleotide (T) insertion is observed in the Rv3724/cut5 gene. Cut5 is expressed as Rv3724a/cut5a and Rv3724b/cut5b in H37Rv strain.
Subcellular Localization:
Cytoplasm. Cell membrane. Secreted, cell wall.
Sequence:
MAPGSHLVLAASEDCSSTHCVSQVGAKSLGVYAVNYPASNDFASSDFPKTVIDGIRDAGSHIQSMAMSCPQTRQVLGGYSQGAAVAGYVTSAVVPPAVPVQAVPAPMAPEVANHVAAVTLFGAPSAQFLGQYGAPPIAIGPLYQPKTLQLCADGDSICGDGNSPVAHGLYAVNGMVGQGANFAASRL
The following text describes a protein:
Function:
Converts protoheme IX and farnesyl diphosphate to heme O.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MPALCATYLIHSGNLRACLRIVPLTKPSVVIAYRHLSKSSSKIAPAAALNTAPIEFTPNTSAASLHERSTVIKDAARSALRCNDTTPTPALPFDVKRVDKANRAAGRKLPAASGVLSAYALMGPYIQLAKPRLTVLVMLSAICSYALSPYPATVLELLSLTVGTTLCSAAANGINMGREPDFDRQMMRTQARPVVRGLVTPMQAYKFSAVSGVIGTAILYAGVNPTVALLGASNIVLYSWFYTSLKRKHIINTWFGAITGAIPPLMGWAAASPLTHPGCWCLAGLLYAWQFPHFNTLSHNIRNEYKNAGHVMTAWKNPKLNARVALRYSLLMFPLCFGLSYYGITDWTYQIDSALVNGWMSFWAFKFWWQQRYNYSKKVYNNKAEFNKGMVLANVYARKTFWVSVLHLPAVLILAIVHKKGRWDWLFSDEGKLVA
The following text describes a protein:
Function:
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Sequence:
MNGTEGPNFYVPFSNKTGVVRSPFEEPQYYLAEPWQFSCLAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTTTLYTSLHGYFVFGPTGCDLEGFFATLGGEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMVVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSNFGPILMTLPAFFAKTSAVYNPVIYIMLNKQFRTCMLTTLCCGKIPLGDDEASATASKTETSQVAPA
The following text describes a protein:
Function:
Required for normal morphogenesis and cell-type stability.
Sequence:
MEIEPVVRISFNGNNNQNNNNNNNNNTNNNSNNNNNNNNSSNINSTNKPSVKKPINQKMISNINNQKSPNPLNSSVDDNNNTNNNNNSNSNGTDEDIIKLARDLTNTFGILLGDSDQPSQFSDVIFKVGDRKFFASKIMLVARSEYFKAMFTGSMKESSIKEITLEGVDPDVFFTVLKYICIGILDLDYDHRMVSSIYQYCDLLGLQRGKELSLATMGKIAQMYLEKPDVESALFLWDSLNQSAIPVESVHPHLRAFVLQYASISLHCDAFYSISLTTLVQMLRNDGLRMEELDILDCVIDWCRENSQASIQQQQQQQQQQLQSANGASGKSHGKRSSSSHLKKHDGDGGSDGSCSSRCSSRRNSLSLKDHHRQHIGNGGGGGGHYNNNDCHSDTEETYSDIDDEEHRNGGGGVGDDFENDSEDGDDDDEDDDEDDDFTDDDDKDDSANDDYEYSTNKDDLDIIEDWDTTIDKNLLDEVLPLIRWENMNIGEAFERLDNLKIIPDKEISNLLRHILKSNRGESFSFLGYHYRRPRNNRKRPYPIEFLLGITQPFDSNVTNEIIPLNSFSSEFGQSTNQFLYRIKKDIKLPANLERFSFKDREFFVQLKEREKGQLAVYLAFGSKLTKPLAISVLASVIGFRFQDSIEFSFKKMFDEGFDSAWGWPKFISLDTLYKQDKYSHYSDSFCLLIELTSQWG
The following text describes a protein:
Function:
Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Induction of the CRP-S regulon also requires Sxy-activated promoter (CRP-S), cAMP receptor protein (CRP) and cAMP. Induces CRP-S site-containing genes which are involved in genome maintenance and transcription or encoding transposases and toxin-antitoxin pairs.
Miscellaneous:
MISCELLANEOUS: Overproduction induces the expression of the competence regulon genes including ppdA, hofB and ssb, although to highly varying degrees. Plasmid-borne expression leads to production of type IV pilin (T4P), the main subunit of the DNA uptake machinery.
Sequence:
MKSLSYKRIYKSQEYLATLGTIEYRSLFGSYSLTVDDTVFAMVSDGELYLRACEQSAQYCVKHPPVWLTYKKCGRSVTLNYYRVDESLWRNQLKLVRLSKYSLDAALKEKSTRNTRERLKDLPNMSFHLEAILGEVGIKDVRALRILGAKMCWLRLRQQNSLVTEKILFMLEGAIIGIHEAALPVARRQELAEWADSLTPKQEFPAELE
The following text describes a protein:
Function:
Ketoamine kinase that phosphorylates ketoamines, such as erythruloselysine and ribuloselysine, on the third carbon of the sugar moiety to generate ketoamine 3-phosphate. Has higher activity on free lysine (erythruloselysine and ribuloselysine), than on ribuloselysine and erythruloselysine residues on glycated proteins.
Sequence:
MDPLALLRKAGLEAEGPALPLHGGDISRVWRVGRFVVKTAQDPPPGLFRAEARGLQALAERGVRVPRVHWVGEEGLVLAYLEPGPEDWEGLARTLAALHRRREGSYLAEPGFLGTFPLPGREGGEWTAFFYERCVLPLLEATWDRLQGLGPKVEALYQRPLPAEGPAPLHGDLWHGNVYFAREGPALLDPSFFVGERGVDLAMMRLFGGFPRRFWEVYGELYPVPEEVERALPRYQVYYLLAHVHFFGQGYLGALWRAISAS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
Subcellular Localization:
Cytoplasm.
Sequence:
MESNTVVPTKSKRPPKSKPQNPIESTIRSFFQTLPSTLFLEISASIDSLITTSPKRWVIYSPMLLLPSGSFSSPHWTSLLSLISPSQKETLFTQILQSVSKKEGKELTHLAINAGIPLHEKEKEGENQREKGEDNILRSPSGLLMLYGDFGPDFTGYEPTEKDFKDAFWVSTKQNGLEQVWAPRWTMFSRGNVKEKARLLGFHDAVATVSDGAKKEIRKEERRNWTAVDLVVRRGEVIEEVGDERIVVFLESNVEAERKLEIMKGLGVVKHVNCGFLPTSEPTWKPAMNILSEDGWLHLHENVGIADVEKRKNEIEEMFRTWLKERVDERKVTVEHVEFVKTFAPDVWHCVFDVYISKQVT
The following text describes a protein:
Function:
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Basolateral cell membrane; Lipid-anchor. Apicolateral cell membrane; Lipid-anchor.
Sequence:
MEAVEANTLQQERLQAIAEKRKRQTEIENKRRQLEDDRRQLQHLKSKALRERWLLEGAPSSASEEDEAMKKQMQEDEVKTKELEETIQRLERELESLENSSSVTSTKENLAEAAAPAKEEKKENIPSVQKSPLGTAIAEKKVSSSPMKAVQGTDMMKAAMYSVEITVEKDRVTGETKVLSSTTLLPQNHCVQGIKVYEDELKVVHAVSAEDGALQNGAQPLSSSEVDELLHKADEVTLGEATASGDAPGSATSSQKATPRREITGLQAKPRENSTEGAEPSREQPVTMIFMGYQNVEDENETKKVLGLEGTIKAELVVIEDAESKAEPEGKDHAPPNGTALEPAAAPLQGDEVPGGQKPGTNATEAKEAEPDMDAKKQRCKCCTVM
The following text describes a protein:
Function:
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MFAFSRKEKKITQRRKMSESSAKSGQSLAGKKDKDVSEKRGRGRPRKQPQQESSEPPPPKRPRGRPKGSKNKATSKGREQGSVSNLPWTSRQCPVRNDATVDQKASVTTTTGKKPRGRPKKIKKDEEEVNISQESSEEEQ
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGVFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQSLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRSALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFETEQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR
The following text describes a protein:
Function:
Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR).
Miscellaneous:
MISCELLANEOUS: Although FhcB and FhcC do not possess a formylMFR dehydrogenase (Fmd) activity and have an unknown function, they are required for the stability of the complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTLRLRGDLPERVDLLNITPLALSGLSEAEAGKLAIGTSRRGLTLGDVFEISLDGSDSLVIEGGSARLDRVGAALSQGSIRVEGDVGQRLGEGMAAGSLTVTGSAGPYAGTGATGGTITIEGDAGDHAGGAVYAAKAGLDGATLVIKGAAGDHLGDRMRRGMILAGSAGAFAASRMIAGTIVVSGALGDHPGYGMRRGTLIAGSHGTLLPTFVETGTPDLVFVRLLAQSLKHLGAAQASLLSGTLRRYSGDLATLGKGELFVPA
The following text describes a protein:
Function:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide, phosphatidylcholine, phosphatidylethanolamine, and small amounts of phosphatidylserine from the lumenal to the cytosolic leaflet of the cell membrane and ensures the maintenance of asymmetric distribution of phospholipids. Does not appear to transport sphingomyelin, inositol phosphoceramide or phosphatidic acid. Required for efficient endocytosis. Required for protein transport from Golgi to vacuoles.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSPSKPTSPFVDDIEHESGSASNGLSSMSPFDDSFQFEKPSSAHGNIEVAKTGGSVLKRQSKPMKDISTPDLSKVTFDGIDDYSNDNDINDDDELNGKKTEIHEHENEVDDDLHSFQATPMPNTGGFEDVELDNNEGSNNDSQADHKLKRVRFGTRRNKSGRIDINRSKTLKWAKKNFHNAIDEFSTKEDSLENSALQNRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNILFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIEDSRRTVLDLEVNNTRTHILSGVKNENVAVDNVSLWRRFKKANTRALIKIFEYFSENLTAAGREKKLQKKREELRRKRNSRSFGPRGSLDSIGSYRMSADFGRPSLDYENLNQTMSQANRYNDGENLVDRTLQPNPECRFAKDYWKNVKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSLKCSKIIKSSRDITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINAGVTPTKKSRISRELNFSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVSTARQLGYSFVGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIPGSTPKDEPKALLICKGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAIGQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDGSYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRKEWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVREMWLRGDFDLYPQGYDPTDPSRPRINEIRPLTDFKEPISLDTHFDGVSHSQETIVTEEIPMSILNGEQGSRKGYRVSTTLERRDQLSPVTTTNNLPRRSMASARGNKLRTSLDRTREEMLANHQLDTRYSVERARASLDLPGINHAETLLSQRSRDR
The following text describes a protein:
Function:
Pentapeptide repeat protein of unknown function. Subject to degradation when reduced.
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MAFSSLSPLPMKSLDISRSSSSVSRSPYHFQRYLLRRLQLSSRSNLEIKDSSNTREGCCSSAESNTWKRILSAAMAAAVIASSSGVPAMAELNRFEADTRGEFGIGSAAQYGSADLSKTVHSNENFRRANFTSADMRESDFSGSTFNGAYLEKAVAYKANFSGADLSDTLMDRMVLNEANLTNAVLVRSVLTRSDLGGAKIEGADFSDAVIDLLQKQALCKYATGTNPLTGVDTRKSLGCGNSRRNAYGSPSSPLLSAPPQRLLGRDGFCDEKTGLCDVK