lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix. Regulates the activity of mechanosensitive Piezo channel; (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Major isoform; MISCELLANEOUS: [Isoform 1]: Minor isoform. Initiates from a GTG codon. Contains a Nucleolar localization signal at positions 45-63.
Subcellular Localization:
[Isoform 1]: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm; [Isoform 2]: Cytoplasm. Secreted.
Domain:
The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm. The cysteine-rich C-terminus mediates protein-protein interactions, including interaction with HIV-1 Tat, transcription factors, AXIN1, CCNT1.
Sequence:
MSGAGEALAPGPVGPQRVAEAGGGQLGSTAQGKCDKDNTEKDITQATNSHFTHGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIGKIKNGHTGLSNGNGIHHGAKHGSADNRKLSAPVSQKMHRKIQSSLSVNSDISKKSKVNAVFSQKTGSSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCNCPCDMDCGIMDACCESSDCLEICMECCGICFPS
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDYEGQRLSEQIMQWLIIVAAVIGFLAGYITSSYRLMLEIYTGGMVLAFLLAVPDWPYFNWHKLSWLPEQPPSEDEAAASSSTLAVQKSKQGKRSSKGKR
The following text describes a protein:
Function:
Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptomyces coelicolor.
Miscellaneous:
MISCELLANEOUS: This putative ketoacyl synthase lacks the active site cysteine.
Sequence:
MSGPQRTGTGGGSRRAVVTGLGVLSPHGTGVEAHWKAVADGTSSLGPVTREGCAHLPLRVAGEVHGFDAAETVEDRFLVQTDRFTHFALSATQHALADARFGRADVDSPYSVGVVTAAGSGGGEFGQRELQNLWGHGSRHVGPYQSIAWFYAASTGQVSIRNDFKGPCGVVAADEAGGLDALAHAALAVRNGTDTVVCGATEAPLAPYSIVCQLGYPELSRATEPDRAYRPFTEAACGFAPAEGGAVLVVEEEAAARERGADVRATVAGHAATFTGAGRWAESREGLARAIQGALAEAGCRPEEVDVVFADALGVPEADRAEALALADALGPHAARVPVTAPKTGTGRAYCAAPVLDVATAVLAMEHGLIPPTPHVLDVCHDLDLVTGRARPAEPRTALVLARGLMGSNSALVLRRGAVPPEGR
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity).
Sequence:
MNSPATLAAKLPWSEWLPQQRWYAGRNRELAAAEPGAVVALRDDLDLVLVDVSYTDGSAERYQVLVRWDAGPVSEFSTLATIGSADDHTGFDALYDPVAPQVLLSLIDSSAVRSSSDGQVSFAREPDVELPLDAYPRVSDAEQSNTSVIFDRGQAAILKVFRRVSSGINPDIELNRVLGRAHNPHVARLLGTYEIGIPGEPPEAACPLGMATAYAANAAEGWAMATASVRDLFAEGDLYAHEVGGDFAGESRRLGEAVASVHATLAEQLGTAQATFPVDHVLARLSSTAAAVPELQQYAGTIEERFVKLVDETISVQRVHGDLHLGQVLRTPESWVLIDFEGEPGQPLRERRAPDSPLRDVAGVLRSFEYAAYGPLVDHADDKQLAARAREWITRNRTAFCEGYAAASGNDPRDSELLLAAYELDKAVYEAGYESRHRPGWLPIPLRSIARLTAT
The following text describes a protein:
Function:
Required for aerial hyphae formation. Probably involved in processing the precursor of SapB to its mature form (Probable).
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MTAATVRGGTPRDSVVSVSNRWEGAGVNKGYAVYCDADPYFYDAPHRTADRTGAARSRYAAASSPVPEGWQRHESGDWLALRPADADLPAQGWKIHVSACLDNAESVLDRVWRHCVDGGTAFKFVPSRYLLHQRNAKYADRAGSGKFVTVYPADEAEFERLVGELSELLAGEPGPHILSDLRIGDGPVHVRYGGFTRRDCYDADGELRPAVSGPDGVLVPDLRGPVFRIPEWVDPPAFLRPHLDARSAVTVTGMPYTVESALHFSNGGGVYLARDTRTGARVVLKEARPHAGLAADGADAVTRLHRERRALERLSGLACTPEVLDHRTVGEHHFLVLEHIDGKPLNTFFARRHPLIEADPGERRLAEYTDWALDVHARVERAVAEVHARGVVFNDLHLFNIMVRDDDSVALLDFEAAHHVDEAGRQIVANPGFVAPPDRRGVAVDRYALACLRIVLFLPLTSLLAVDRHKAAHLAEVVAEQFPVDRAFLDAAVEEITRVDGSTRVDGSTRADETTRADETTRLDVTTRVHGAPDAARRPAGPVAPVRPDDWPRSRDSMAAAIRASATPSRTDRLFPGDIAQFATAGGGLAFAHGAAGVLYALAESGAGRDEDGEQWLLERTKRPPSGMPLGFHDGLAGLAWTLERLGHRDRALDLAELLLDQPLDHLGPDLHGGTAGLGLALESLAATTGQAALHSAALHCAELAADGLPGGSVPADRVSRGRARAGLLYGGAGRALLFLRLFERTRDSALLDLARDALRQDLARCVRGAGGALQVDEGWRTMPYLGAGSVGIGMVLDDYLAHRADEEFARAANEIVAAAQAMFYAQPGLYRGVAGMVLHLGRTTATAPGTGPRAVRRQLDALSWHAMSYRDRLAFPGEQMMRLSMDLSTGTAGCLLAVASVLGDAPAGLPFLPPPRRSGGPLTRPHQEP
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSSANPRTLAGPIVQLFRDVMKLHRERLPPPMRDLGDSYARAEFRSHLRGKTTMEQWKQFVREWQVYLATLRGDEQAAASADANVARVFELLSDDQRKRMDQLQQELNSRTGGGGGDSDGGDAGRGPHQ
The following text describes a protein:
Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDLLVYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEAAVEIHTDAVKLGSRVLLVDDLIATGGTMLAGLELIRKLGGEIVEAAAILEFTDLQGGKNIRASGAPLFTLLQNEGCMKG
The following text describes a protein:
Function:
Non-catalytic component of the proteasome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFEHINFPVFGQVDYFGKQSQQQLQPQQQYTPSHGGKKNTLDPIVTGTSIIAIKYDKGVVMGSDMLLSYGSLARFNSIQRMTKFGGNTIIGASGEYSDFQSITTTLNELVTDDHCMDDGSRLSPEEIWNYLARILYNQRNKGNPLWNTCVVIGYQGGKSFLGKVDLVGTCFKEDIVTCGYGSHIALPLLRKARDDNPNMNLEQAKKLIEDCLRVLFYRDARSSKKIQIAVAGEQGIDISGPIELETYNWNSGEAAVKNFSQV
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.
Sequence:
KNEMRRLLKYERKVESKRIKRKKEHERRREREKAMEKASEIQLSRFARSNLKRREVDEKMESVMRNDSHALVVCVDLSWSHSMNDKEINKLASQLGRLYGSNRKAEAPAHVYFTGFKKGTLIWNECHRKHNGFNEYKISMTDKSPIEMFNNENIIYLSPDAETALSNVEAGSVYVIGGLVDETVCKKLTLDAATEHGICTRRLPVKEFMKKSGRHKNYSTVFAVNQVFDILLKYHSAKDWVEAFKLGVPPRKGYVFNDDVITS
The following text describes a protein:
Function:
Probable serine hydrolase.
Sequence:
MLPAFMSLRHFTTTTMRRAASEFRMPVPWGELRGQVWGPSHGRPVLCLHGWADNSGTFNTLVPLLPNDWRFVAIDFPGHGLSSHRPDGCFYAFPFYVADVRRVVEALQWKRFSIIGHSMGGNVAGMFSALYPEMVESVVLLDTYGFLPTEVTDMFTNMRKGINDQIQYDNMANERKERVYTYEKAKERLKVANPYLSDQSADILLERAVREVDGGFVFTRDFRINLKNIIYINIDQCLHVLSQVKAKVMLLLAKDGLFKTFTLPDGYADRICKSWTDQKATFVEVEGDHHVHLNNPEAVSSVITDFLQPQSPDQTESQSGNQTSRL
The following text describes a protein:
Function:
Involved in salt stress response. May positively modulate plant tolerance to salt stress.
Subcellular Localization:
Nucleus.
Sequence:
MCSGPKSNLCSSRTLTEIESRQKEEETMLLLEFAACDDLDSFKREVEEKGLDLDESGLWYCRRVGSKKMGLEERTPLMVAAMYGSIKVLTFIVSTGKSDVNRACGEERVTPLHCAVAGCSVNMIEVINVLLDASALVNSVDANGNQPLDVFVRVSRFVASPRRKAVELLLRGGGVGGLIDEAVEEEIKIVSKYPADASLPDINEGVYGSDEFRMYSFKVKPCSRAYSHDWTECAFVHPGENARRRDPRKYPYTCVPCPEFRKGSCPKGDSCEYAHGVFESWLHPAQYKTRLCKDETGCARKVCFFAHKREEMRPVNASTGSAVAQSPFSSLEMMPGLSPLAYSSGVSTPPVSPMANGVPSSPRNGGSWQNRVNTLTPPALQLNGGSRLKSTLSARDIDMEMEMELRLRGFGNNVEETFGSYVSSPSRNSQMGQNMNQHYPSSPVRQPPSQHGFESSAAAAVAVMKARSTAFAKRSLSFKPATQAAPQSNLSDWGSPNGKLEWGMKGEELNKMRRSVSFGIHGNNNNNAARDYRDEPDVSWVNSLVKDSTVVSERSFGMNERVRIMSWAEQMYREKEQTVV
The following text describes a protein:
Function:
During embryonic development, regulates the integrity of the genome and therefore the cell cycle progression by preventing rereplication through an APC-Cdh1-dependent mechanism.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKCPNYTEDSTVLCHMEKTETDLGEVKGHKVSPRKTGALSLRSPAATNVSTPLESRSKGPHNKENYQNKRHSLDMASDDEVIFSGSGLTEDSGYLSLHNSQVDVDGLDSLERSEENCVSSQSLDVECHSGPCLPVLNFQEEACRELQRSYKKNRSYDWTVVDKVAENFGLHNVIGGKMGRQFVDILCKLMRKDMRHILARILGLLGDCDLISCTKVSRTWRKIICQDQLALQRWKKAEKTRRDSGRSMGSLSRDFTLDRVVFSCMQTVSSPPAHKAVKKPPCHMGGAQNATKSSRFQQYVEAAQSLKQHESLRRCSRCSSPARFDAVMQRAVCTRISCAFEFCTLCQSAFHDSTPCRNTVRSFSSTQKTLVAGSARSKRSIRRL
The following text describes a protein:
Function:
Ligand for the KLRK1 immunosurveillance receptor. Binding to KLRK1 stimulates cell lysis in vitro.
Subcellular Localization:
Cell membrane.
Sequence:
MAKGATSKSNHCLILSLFILLSYLGTTLADGTDSLSCELTFNYRNLHGQCSVNGKTLLDFGDKKHEENATKMCADLSQNLTEISEEMWKLQSGNDTLNVTTQSQYNQGKFIDGFWAINTDEQHSIYFYPLNMTWRESHSDNSSAMEQWKNKNLEKDMRNVLITYFSHCLNKSSSHFREMPKSTLKVPDTTQRTNATQIHPTVNNFRHNSDNQGLSVTWIVIICIGGLVSFMAFMVFAWCMLKKKKKGAPCCSSSSAVLITSYNHVTLQHIPVASPAKETYF
The following text describes a protein:
Function:
Involved in chlorophyll synthesis and chloroplast protection against oxidative damage.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MNRSLPASLIHSYLSPFPLLFPSSNHARFLGFQCHTWNPIRRRLNFAVTADLSKSSPSLHSASDFQLPWVGPVPGDIAEVEAYCRIFRTAERLHSVLMDTLCNPFTGECSVSYDVSPGENPLIEDKIVSVLGCLVSLINKGREDVLSGRSSAMNSFRGANLDATEDNLPPLAAFRSEMKRCCESLHVALENFLIPGDERSLNVWRKLQRLKNVCYDSGFTRGEDYPCHALFANWNPVYLHNSKDETSAKNSEIAFWSGGQVTEEGLKWLIERGFKTIVDLRAETVKDEFYSASLHDAIGSAKVKVIKIPVEARTAPKMDQVEKFASLVSDASNGLIYLHSKEGVWRTSAMISRWRQYATRSGSQIVSNQTIVPVDIDTSSKLELNQNGAKESLEISIIGETFPCAEDSQSFLLDSAHHSSINRKNYAEVSQNVNGAYNGPSPTQDTTSLRAVVNGGIEIDPLKAQIPPCNIFSRKEMSNFFRTKKISPQNYLHRRMKTKEKFSTEVTASRVQRSSVNNSDKSGIVEAGNFNGSPSVKDSSSKTQYASTTKMNYGNGDSHVSANPVLEGLEVEGRNPLTTVASAAVGGKVPSKSEINDLKSNGQATSVSSNGNVESVEGNMCASATGVVRVQSRKKAEMFLVRTDGFSCAREKVTESSLAFTHPSTQQQMLMWKSTPKTVLLLKKLGQELMEEAKEKMNVLVEPDIHDIFARIPGFGFVQTFYSQDTSDLHEKVDFVACLGGDGVILHASNLFRSAVPPVVSFNLGSLGFLTSHAFDSYRQDLRQVIHGNDSLDGVYITLRMRLQCEIFRNGKAIPGKLFNILNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYSTAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPDSARLELKIPEDARSNAWVSFDGKRRQQLSRGDSVRISMSRHPLPTVNKSDQTGDWFHSLIRCLNWNERLDQKAL
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair (By similarity). Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ankzf1 and repair by elac1 (By similarity). Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts (By similarity). While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded (By similarity). The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA (By similarity). This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle (By similarity).
Subcellular Localization:
Mitochondrion. Cytoplasm. Nucleus.
Sequence:
MWAKLFLRPSFVNRVHLTWSCRALLTMQLKTKEFESLFTDGLVGLAEIFQKNQFELRIAGGAVRDLLSGKRPEDVDFATTATPEEMKSMFQTAGVRMINNKGEKHGTITARLHEENFEVTTLRVDVQTDGRHAEVEFTTDWQKDAERRDLTINSMFLGLDGTLYDYFQGYEDLKNRKVRFVGSASLRIQEDYLRILRYFRFYGRVAAEPGQHEPETLEAIRENARGLAGISGERIWVELKKMLVGNHAGHLLELVYELGLAQYTGLPADGDVEEMKQVWQRAHVSSPKPMTVLAALFRKQADVENLDQRLKVSREEKNLGLFLVKYRRDLVKGHDEHDTMKPYTDFITDSREPDTQSKVLELLKYQGENKLLDELRRWSIPRFPVSGHDLRKLGYTSGKEIGTILQELRDMWKKSRYQMSKDELLSTLSQS
The following text describes a protein:
Function:
Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.
Subcellular Localization:
Nucleus.
Sequence:
MIGGYYDRNPLLKGTLTSVERDRLRERERQARAQMTSQVDDQGTFLFGAPVRVNPSSSDPVTQQIQSKLGDFQRLRPFLDQKDLIGVDGVPPSPGVPNGPSSRHNPFMSNLASAAVSSRLQPSPESRPEFKKPHHHQIHHQHQRGGYVKPADGKPPYEGRGGYPGQPVKHGSGITNHRSNGILPAKGPPQSSPNSSAPLLPSSNSSRLHNSGARNHPRNTTFEQNQGPPAGPREPLPSATPNTDMENIFKEMIEVRRPLTAIAATPRKEPDNKFTFSPVFTKLTESTPTPSAPKKREKVAAPRPSTDLRDDLNLSDDSDDDQKQSSKLPVEKMVSPLGATPAVGSFSKMEYPPEPADPAGSSSSDSGSDSGSESDSSSDDSAEDNVTSSNPSKSNVVPAETGPSSPPPPEEKDKKRWNLGSYLVIDQNNAKADSVLSPKVQTSPLTSSMLPLAVDKKKVTEESDASDSTKDLDSVVAEALASATVPLLSSFSDSDDSVTERRTKRRKHTIIQSVTKNSESDSDDAERTKKPKPVRRASPRTKSVDSCSDSDNNSANIIKKRLSPLPHKSPEQLVKPKQSRGRPRKIKPAVSGSDKKPRKRGRPPKPRPSHPSSSDEEDNVDKRPVRRRTISKRDASSSSDSDSRYRKYESPKKIPKPFEDKIKRPAIKNDSDDDWGKKNKNKLKPRQRSESESSKKNDSPKKEVFRRKGRTSNPHHKSAATLPTTTDSSDSDSGPSKRLQRSLSSRSRSRSSDSDTNILAKSPVNKVEETKPIKDKNKSDTLRKLFTPKRDSEGGKGGGKGGGKGGKGGKGKGGVNVIFADGGNERCVSPVEDETMPTISNPTLLSPIPHKEAKPPLASPCAEPIKFIKTEPLDDEKISMKVKIGLNRIDLNAVICLKNKLEALKHPYFREFEKKKLSDNDNESKKKDSDLAELKHKSKKRKRRNSSSSISSLSTVSNLSHSSKKLEHRKDRENHKMKRRKDDEIYPRSQSDNISLTNAPPTNHEREGSRSRQVISPVDKNKSQSTREYHSYFEKPDEPLECEERAQSQYLSDATRLKHLADKETDTTKQCMLYLEAVLFFLLTGNAMELTRVTENACFTMYKDTLSLIRYITSKFRSQHNASSKHNKLAVLSYRCQALLYYKLFKMKKHEAKDYQKVLSEYFNNKAVAIPPEQQTQQGQGTPSPMSPTPSPAGSVGSVGSQSSGYSSGELAARGSNVPPPVPSTHAQSGGAHVWIPQNIYNAMYKQNQNFTYLLSCQDLWDTADALVIKGKHTDFFIDLDRLCKPLTMHSSLIDLVRYIREGIKRLNES
The following text describes a protein:
Function:
May be involved in proper membrane localization of Rab GTPases.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTDIGKHNTEIEQDEMENLLRMDPVRSSLDVESRAIEPDNIAGESIVETRFTGGDSLDEPIRVTLFNEFRAIGEKLVYVLYPKNAQVLRDWDLWGPLIFSLVIALALALSTDKIERESVFTVVVALIWFGEAVCSLNIKLLGANISIFQSMCILGYSSFPLMIASIVCAFVPLIFIRIPVIVAMYAWTLFAAMGVLQNSNLSNKKLLAVYPLFLFYFSLAWIIFL
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane; Multi-pass membrane protein.
Sequence:
MARRSGPAPAVYGEEFTFVSPVVKYLLFFFNMLFWVISMVLVAIGVYARLMKHAEAAMASLAVDPAILLITVGILMFLLTFCGCIGSLRENICLLQTFSLCLTIVFLLQLAAGVLGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKEFHCCGGISYKDWSQNMYFNCTEDNPSRERCSVPFSCCLHKSRQTVINTMCGQGMQALDYLEAGKVIYTNGCIDKLVNWIHTNLFLIGGVALGLAIPQLVGILLSQILINQIKDQIKLQFYNRQHRADPWY
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
Sequence:
MSVDPITCHILDTTLGTPASGVIVQLFHISNDPLLSSISEDTTTTNGKHFAMAKTDNDGRIKQWIINPNGDFQNLGITKNSSKNNHQSWNNLKPGIYKAKFLTGKYFLSLAQNQQGSTSGGDGGRTFFPFVEISFIIDNPPDNHYHIPLLLSNYSYTTYRGS
The following text describes a protein:
Function:
RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. The formation of a surveillance complex is believed to activate NMD.
Subcellular Localization:
Cytoplasm.
Domain:
The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
Sequence:
MYGFNIGKAENAGLHLDNKKSENNNSSNNELHKVINTINNGFQFKDDDDEDNENNLNNESSSDEENQQQQNNNNNNNKNQFEDDDEDQEEEEYISGDDLNNNGQESDDYEEEEEDDDEDEEEEDEESKKLNYDSFFGANMSHNMDFLNSQNINSQIGLMDPHLHSSQLNFEEPQEEIELPAHACAYCATHELSTVVKCMHPSCGKWFCNGKGKTKSSHIITHLVKSKHKEVALHPESSFGDTTLECFNCGCKNIFLLGFITARTESVVVLLCRDPCASGPSKEVNWDMSSWQPLINGGEKAFCSWLVKTPSQVDSERSRQITIQQILRLEEFWKMDPEATLLDIEAPRSDDEKPASTQLAYKDAYEYREIISPLIELEAKHEKELRESLSQSGISIEWSQGINKRYTATFPFSRSDLEFKVVPGDELKLQFISSTGGVIEWEDTGRVIHIDDENLLSLETKSRCSFDSGPKGSYRMEMVWRSTSSERILSAMKSFAIKEQALSSYLYHALLGHPDIPPAPLDIQLPTNFHLKNLPRLNESQISAVNKVLTAPLSLIQGPPGTGKTVISSFIIHHLVKYVKGNDKVLVCTPSNVAIDQLTGKLHEIGLKVVRLSSKLREEVASPVEHLTLHKQVYKLDQMGDGELGKLRKLKEAFGSLSNEDEKRYIYLRRMMEMAILRKADVICATCVGAGDPRLSQFRFPHILIDESTQASEPECLIPLMMGAKQVILVGDHRQLGPVLLCKKVVDAGLSQSLFERLISLGHHPERLTIQYRMHPSLTEFPSNTSYEGQLVSELSHTDRDSQSKFPWPQPKDPMFFFNCTGSEEISSSGTSFINTTEASICEKIVTKFLELGSLPGQIGIITPYEGQRAYITSHMQKSGKLNLELYKSIEVASVDSFQGREKDYIILSCVRSNDYQGIGFLQDPRRLNVALTRARFGLIILGNAKVLSKDPLWNSLISHFKNKNVLVEGSLANLKQSPVILQKPKKLYGQGKLPIPGQNSNSFNYDREHIDPNIGMNMVYGISNNNINNNSNNINNNNNNNINNNINNNNNQRFNTQDGRYSNSQTSSSSQTYYGSTNSSGNTINSNQNQFFNTPSSYSANTGSSYQYRFQQYQQLQQPQPQQQQQPQQQQQPQQQQQPQQPQQQQPQQQKQYQQQQQQQQQQQQQQQQQQQQQKQQPHQQYQSQKQQQQQQYQQPQQYQQQNQQYHQSQLPPKQYHNQRFNNNNNNNINNNNNNNNNNNNNNNNNNNNNNINNNNSKNQNQNQSPRRSPVVGTLQLHCKFDSQPNNNKHISDPNQPQISNPNMSIPLSQSLSFNDLSQEQFNKSNSRKD
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MEEECEELQVPMGILKSIRFSISNNKDRKNMAVMDVEAANQVTDSRLGLPNPDSICRSCGSKDRKVCEGHFGVINLKYPVINPYFLKEIATLLNRICPGCKYMRKKQSQSSEDRPERCRYCTSNTGYPLMRFRVTTKEVFRRSGIVCEVSEDNLFKLSKRGLSSLPPDYWEFLPKDSNIDESCLKPSRRILTHAQVYALLCGIDERLIRKDIPMFDSLPLTSFPVTPNGHRVSEMVNQFTGARLIFDERTRIYKKLVGFEGNGLELSARVIECMQYSRLFSENMSPSQESANPYQKKSDTPKLCGLRFMKDVLLGKRSDHTLRTVVVGDPCLKLNEIGIPRRIAERLQVSENLNDWNRERLVTSCFHKLLERGETHVRRGGSLVAIRVIEDLQTGDSILRTLKDGDTVLMNRPPSIHQHSLIAMSVKVLPTTSVVSLNPICCLPFRGDFDGDCLHGYVPQSIQAKVELDELVALDKQLVNRQNGRNLLSLGQDSLTAAYLVSVETNCFLNRAQMQQLQMYCPFELPPPAIIKASSSEAQWTGMQLFGMLLPPGFEYTYPLNDVVVSNGGLLSSSDGSGWLRDGEGNFIQGLLKEHKEKVLDIMYSTQEMFSQELQMRGLSVSLADLYLASDPESRRNLTEEISYGLQEAEQVCNKQQLMVESRRDFLAGNVEDMAADLDRFCYERQRSATLSKLAVNAFKDAYRDVQSLAYRYAAESNSFLIMSKAGSKGNMGKLAQHSMCIGLQNSSVALSFGFPRQLTCASWNDPNSPLRGAKRQDQTGHESFVPFAVIENSFLTGLNPLESFVHSVTSRDSSFSGNADIPGALNRKLMFFMRDIYAAYDGTVRNSFGNHLVQFHYETEEDITGEAVGSLSACALTEAAYSALDQPISLLETSPLLNLKNVLECGSKKGLKEQTMSLYLSETLSKKKHGFEFGALDIKSHLEKLSFSEIVSTSMIIFSPRTNTKMPMSSWVCHFHISKKVLKQKQLDVESVVSSLNKQYANRKKELKLDVIDLEIQSTNHCSWDDKSMEDDRFCITVTVLEASTHGSLELDAIRLVLIPFLLDSPVKGYGEIKKVEILWADRPKAPKRNKKHMAGELFVKVTMHGVRGKKNIWSALLETCLPIMDMIDWTRSHPDNIRQCCSVYGIDAGRSIFLADLESAVADTGKGMLREHLLLVADCLSVTGEFVALNPKGWSKQRQAESTPAPFTQACFSSPSQCFLKAAKEGVTDELQGSIDALAWGKVPSFGTGDQFEIIISPKDHGFSSTPVDVYDFLSSTATLPKRKASSLPKSDNFTVQPFPLLDTALSKAVKTLDGKGLTRSQLRTIFTWDDIEKLSRSLKRILYNYEIDATLNERDERLLMMALLFHPNRDEKLGPGFRGIKVANSKHGNARCFEVVRTDGTTEDFSYHKCVLGATEIIAPKRVNFYKAKYLRNGTVQAGAI
The following text describes a protein:
Function:
Catalyzes the oxidation of oleanolate at the C-23 position to form hederagenin.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MDGVVVTYTKIAAAVAVAVVVVGWAWKVLNWVWVSPRKLEESLRKQGFRGNSYRLFYGDLKESSEMTRKAKLKPINLSDDPVLRVRPFIHQTVKKYGKSSFIWIGPTPRVQIMDPEIIKEIMVKSYKFNKPKRNPLVKLFADGLANHEGELWAKHRKLLNPAFHLERLKCMLPAMYFSCIEMVSKWDKMISKDGSRELDVWPFLQRLTSDVISHTAFGSSYEEGNIVFELQTEQAELVMKTLQSVYIPGWSYLPTKRNRKMKEIDRKTQSCLMNIINKKTKAMQAGEGSTDDILGILLESNLKEQLGQGKKNVGMSIQEVMGECKQFYFAGQETTSGLLVWTMVLLSIHPNWQARAREEVLQQFGNAKPDFDNLNHLKIVTMILYEVLRLYPPVDTLFRRVDQETTLGDITLPAGVQISLPIMILHHDQNIWGDDAKEFNPERFSEGVSKATKNQVVFFPFGWGPRICIGQNFALLEAKLALAIILQRFSFELSPSYTHAPTTVLTVQPQHGANLILHKL
The following text describes a protein:
Function:
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigL. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Domain:
The cytosolic domain interacts with sigma factor SigL.
Sequence:
MTMPLRGLGPPDDTGVREVSTGDDHHYAMWDAAYVLGALSAADRREFEAHLAGCPECRGAVTELCGVPALLSQLDRDEVAAISESAPTVVASGLSPELLPSLLAAVHRRRRRTRLITWVASSAAAAVLAIGVLVGVQGHSAAPQRAAVSALPMAQVGTQLLASTVSISGEPWGTFINLRCVCLAPPYASHDTLAMVVVGRDGSQTRLATWLAEPGHTATPAGSISTPVDQIAAVQVVAADTGQVLLQRSL
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MRALPRTTGPQAGRQTSPTHVPIATHAVSPLNCAHAWWRPVGDVSRSSVAGLSTWAPTRSFAAGSTRASRPPRVAVSASSDAGLLSGEEAFFASEHASFAELGVSPAIQAALETSGLKRPSRIQELAAPHILRGRNVVVAAETGSGKTLSYLVPIAHLMLKQRTAMQQHAAALEAAGPAADGAERPRFTRYLALVLCPNVALCQQVAAAVNALRGPAAADGSSQQQQQQQLVSAAVINSSNPPPFETPDVVVATPAGLLNIIDDAGGAYGWLWSEEGMQARIRHVVLDEADLLLTPAYSRATQRILTLFKTADRRRVEAKLFDELGLAGKDEFDRLPRALQVAAWTGGAPAMLAEGYRPKRSLNPDAKYGPYWRRQYIYSAATLPAATYSDVGSAIAKAHPDAVWVSTDLLHSSKPQVEHAWREVRDDDFTTNLLDSIKSDPDYQARSGKTLVFAADGASADAASEVLAGGNVPHVVYHKSRPMGEQAAALATLREQPGCVMVCTDAAARGLDVEDIKHVVQADFAANAIDFIHRIGRTARAGRGGRVTSLYREHNRALVEVLQSYIADGVALEAAFSRARSFSKKLKKTGGVFVPRGMAAGGEEAEAAQANAGEGAGEGQEGAAAGPAAGRGGPGRGAGGGRGAGRGRGRAGREQAAQEEAVRS
The following text describes a protein:
Function:
Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Maintains the global inactivation of ARAC11/ROP1 at the apex in pollen tubes in order to regulate the polar cell growth.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Localizes to the apical plasma membrane and accumulates in the clear zone of growing pollen tubes.
Sequence:
MANKNAESSSQPPPHVQPNQQQQQQPPIANEQEQEPHGDTCSIPPAQSGNTDSRSRGGNTVFKSGPLSISSKGIGWTSWKKRWFILTRTSLVFFRSDPSAVQQKGSEVNLTLGGIDLNNSGSVVVKADKKLLTVLFPDGRDGRAFTLKADTMEDLHEWKAALENALTQAPSASHVMGQNGIFRNDHADPAVGVDEKKDETPTKSTVLGRPVLLALEDVDGAPSFLEKALRFVENHGVRIEGILRQAADVDDVEHRIREYEKGKNEFSPEEDAHIIADCLKYFLRELPSSPVPASCCNALLEACRTDRGNRVNAMRAAICESFPEPNRRLLQRILMMMQTVASNKTVNRMNTNAVAACMAPLLLRPLLAGDCEIENDFDVGGDGSMQLLQAAAAANHAQAIVITLLEEYESIFGEGSLSPGLYSDSEESGSGTEEGSDDEEYDDDDDGSQGSEDYTDEEEDLENESNGSYSESAASEDKYADSIDPDDHKINDNLSTESKSPKRSKEPKKLLSGSRRSSLPRHDDGKKDEDIVVKGVNNTEVKAVVEVSTSEDKNSSTSDVASDTQKPSKLSDAPGGSKRHWGRTPGKKNLSMESIDFSVEVDEDNADIERLESTKLELQSRITEEVKSNAVLQASLERRKKALYGRRQALEQDVGRLQEQLQQERDRKLALETGLNMSKGNQPIPETIDENLKKDLQEVAQAEADIAKLEHKVDDLENRLGHHDGKASGSTHSASKESRKLPEHNAKMKEKQKDTEAASTHISERSTSKDGQGAARENETEKQQDSRSKSSQQETSRGSSKLVGLSKRSGTKGEGSTTTTSALSKLTMRLNFLKERRSQIANELQNMDKGKTLGQPSPTSGQNRVSEETEKGSGSNQDPDSSKLQSPHILDRGRSENGGDRGRGSSGGNHPNTTPRTFSR
The following text describes a protein:
Function:
May play a role in mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MGRSRSPASPAHRRREKERSERKKRREPRSREREAIGVAPAGGSGSGGAGRRDRERDRDRSRSRDRERERERDRARSRRSRSRSRVAGGGGGGGGGGSSGGNSSSGPSTSRRTTRNNAAATAADRPKINEADLEGKSPEEVEMLKTMGFCTFDTTKNRKVEGNDVGEVHVILKRKYRQYMNRKGGFNRPLDFVA