The following text describes a protein:
Function:
Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes. Plays a role in basement membrane organization. May promote cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration.
Subcellular Localization:
Cell junction. Cleavage furrow. Cytoplasm. Secreted, extracellular space, extracellular matrix.
Sequence:
MISWDMVHTVFLFALLYSSLAQDASSQSEIRAEEIPEGASTLAFVFDVTGSMYDDLVQVIEGASKILETSLKRPKRPLFNFALVPFHDPEIGPVTITTDPKKFQYELRELYVQGGGDCPEMSIGAIKIALEISLPGSFIYVFTDARSKDYRLTHEVLQLIQQKQSQVVFVLTGDCDDRSHIGYKVYEEIASTSSGQVFHLDKKQVNEVLKWVEEAVQSSKVHLLSTDHLQEAVNTWKIPFDPSLKEVTVSLSGPSPAIEIRNPLGKLIKKGFGLNELLNIQNSAKVVNVKEPEAGMWTVKTSSSGRHSVRITGLSTIDFRAGFSRKPTLDFKKTVSRPVQGIPTYVLLNTSGISIPARVDRLELLSISGSSLKTIPVKYYPDRKPYGIWNISDFIPPSEAFFLKVTGYDKDDYLFQRVSSVSFSSIVPDAPKVTMPRKTPGYYLQPGRIPCSVESLLPFTLSFVRNGVTLGVDQYLKESASVNWDIEKVTLSDEGSYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERTVLTCLVISAVDYNLTWQRNDRDVSLADPARMRILANLSLELRSVKFSDAGEYHCVVSNEGGSSAASVFLTVQEPPKVTVMPKNQSFTAGSEVSIMCSATGYPKPKIAWTINDMFIVGSHRYRMTSEGTLFIKNAVPKDAGIYGCLASNTAGTDKQTSTLRYVEAPKLIVVQSELLVALGDTTVLECKTSGVPPPHVKWFKGDLELRPSTFLIIEPLLGLLKIQETQDLDAGDYTCVAVNDAGRATGKITLDVGSPPVFIQEPIDVSVEIGSNVTLPCYVQGYPEPKIKWQRLDNMPIFSRPFSVSSISQLRTGALFISNLWASDKGTYICEAENQFGKIQSQATITVTGLVAPLIGISPSVTSVIEGQQLTLPCALLAGNPIPERRWVKNSAMLVQNPYITVRSDGSLHIERVRLQDEGKYTCVASNVAGTINKTTTVDVHVLPTIQHGQQILSTIEGIPVTLPCKASGIPKPSIIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNAAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITEARVSDTGMYLCVATNIAGNVTQSVKLNVHVPPKIQRGPKLMKVQVGQRVGLPCSAEGTPLPVITWFKGRSTVLVDGVQHISSPDGTLSINQAMLSDTGVYTCVATNIAGSDETEITLHVQEPPTLEAPEPPYNTPFQERVVSQRIAFPCPAKGTPKPTIKWLWNGKELTGREPGISILDDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVMKDKEQITNVSVLVNQLTNLFCEVEGTPSPIIMWYKDDVQVTESSSMQIVNNGKVLKLFKATPEVAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGASSPNEVSVVLNHDTTLECQVKGTPFPIIHWFKDGKPLFLGDPNIELLDRGQVLRLKNARRSDKGRYQCAVSNAAGKQAKDIKLTIYIPPSIKGGNVTTEISALINSIIKLECETRGLPMPAITWYKDGQPVISSSQALYIDKGQFLHIPRAQVSDSATYTCHVTNVAGTAEKSFHVDVYVPPMIEADLALPLNKQVVVAHSLTLECKAAGNPPPVLTWLKDGVPVKASDNIRIEAGGKKLEIMSALEVDRGQYVCVATSVAGEKELIYEVDVLVPPAVEGGGETSYFIVMVNSLLELECQVTGSPPPTIMWLKDGQLIDERDEFKILLNGRKLVIAQAQVSDTGLYRCVATNTAGDGKKEFEVTVHVPPTIKSSGLSERAVVKYKPVTLQCIANGIPHPSITWLKDGQPVNTAQGNLKIQSSGRVLQIAKALMEDAGRYTCVATNAAGEGQQHIQLHVHEPPSLEDAGKMLNETVVVSNPIQLECKAAGNPLPAVTWYKDNRPLSGSASVTFLNRGQIIDIESAKIADAGIYKCVAINSAGATELFYSLQVHVPPSISGSNNMVAVVVNNLVRLECEARGIPAPSLTWLKDGSPVSSFANGIQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVAPNIMGEEQNISVLINQAVELLCQSDAIPPPTLTWLKDGRLLLKKPGLSISENGSMLKIVDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIYSSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLADSAGRVRTLSGGRLLQISIAEKSDAGLYACVASNVAGTAKKDYKLQVYIRPTISNSGSHPTEIIVTRGKSISLECEVQGIPQPTVTWMKDGRPLTKGRGMEIMDEGRVLQLKNIHVSDTGRYVCVAMNVAGMTDRKYDLSVHTPPSIIGNHETPENISVVEKNSVSLTCEASGIPLPSITWLKDGWPVSLSSSVRILSGGRTLRLMQTRIEDAGQYTCVVRNAAGEERKIFGLSVLVPPRIVGENTWEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQLLQEDDTHHIMSGGRFLQITNAQVSHTGRYICLASNTAGDKSKSFSLNVLVSPTIAGVDGNGSPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTALESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLLGPGLSPKEVKIRVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAASGHTLQIKEAQISDTGRYTCVASNLAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRSGEAKDVIINNPISLYCETNAAPPPTLTWYKDGRPLTSSDRILILPGGRVLQIPRARVEDAGRYTCVAVNEAGEDSLQYDVRVLLPPSIKGASSDLPEEVTVLVNQSVLMECISSGSPAPRNSWQKDGQPLLEDEHHKFLSNGRILQILNIQITSIGRYVCIAENTAGSAKKYFNLNVHVPPSVLGPNPENLTVVVNHFISLTCEVSGFPPPDLSWLKNEQPIKLNTNALIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKVFLTVYVPPSIKDQGSDSLSVVNVREGTPVSLACESNAVPPPVITWYKNGRMITESTHSEILADGQMLYIQKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEKEVVVETISNPVTLTCDATGIPPPTIAWVKNHKPIENSDSLEVHILSGGRKLQIARSQRSDSGNYTCIASNMEGKAQKSYSLSILVPPSVAGAEIPSEVSVLLGENVELVCNANGIPTPLIQWLRDGKPVTGSETERIRVTANGSTLNIYGALPSDMGKYTCVATNPAGEEDRIFNLNVYVPPAIRGNKEEAEKLMALVDTSINIECRATGIPPPQINWLKNGLPLPLSSHIRLLSGGQVIRIVRAQVSDVAMYTCVASNRAGVDNKHYNLQVFVPPNLDNAMGTEEITIVKGSSTSMTCFTDGTPTPRMSWLRDGQPLGLDAHLTVSTQGMVLQLVKAETEDSGRYTCIASNEAGEVSKHFILKVLEPPHINGSEEAVEISVIVNNPLELTCIASGIPAPKITWMKDGRPLPQMDQVQTLGGGEVLRIASAQVEDTGRYTCLASSPAGDDDKEYLVRIHVPPNIAGTDESRDFTVLRNRQMTLECKSDAVPPPVITWLKNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNAPPNIRSGPQSLVIHLNKSAVLECFAEGVPTPRITWRKDGAVLSGSHVRYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRKRIDLQVHVPPSIALGPTNITVTVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNDAGEDKRTVDLTVQVPPSIADEPTDFLVTKHAPTVISCTASGVPFPSIHWMKNGIRLLPRGDGYRILSSGAIEIFATQLNHAGRYTCVARNAAGSAHRHVTLHVQEPPAIQPQPSELDVILNNPILLPCQATGTPSPFITWQKEGINVIASGKSHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHPKEYIIVVDKPIMLPCEADGLPPPDITWHKDGHAIMESIRQRILSSGALQIAFAQPDDTGQYTCMAANVAGSSSTSTRLTVHVPPRIRNTEVHYTVNENSQAVLSCLADGIPTPSINWKKDNVLLANLLGKYTVEPYGELILESVVPEDSGTYTCVANNAAGEDAHTVSLTVHVLPTFTELPGDASLNKGEQLRLNCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENTVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPAPTIQWSRRGMDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVAANEAGVVERSMSLTLQSPPIITLEPVETVTNVGGKVTLNCQATGEPHPTITWSRQGHSIPWDDRVRMLSNNSLYITAAQKEDTSEYECVARNLMGSVLVRVPVTVQVNGGFSQWSAWRSCSVTCGKGIQKRSRLCNSPFPANGGKPCQGLDSEMRNCQHKLCPVDGSWSEWSPWEECTRSCGRGNRTKTRTCNNPSAQNGGRPCEGNAVEIIMCNIRPCPVHGAWNTWQPWGICSKSCGKGTQTRTRLCNNPPPSFDGSYCEGAETQMQVCNERHCPVDGRWATWASWSACTVSCGGGARQRTRDCSDPVPQYGGNRCEGSDVQSDFCNSDPCPTHGNWSPWSGWGICSRTCNGGQMRRYRTCDNPRPSNGGRACGGPDSQMQRCNTEMCPVDGSWGNWHSWSRCSASCGGGEKTRKRLCNTPVPSKSGRPCPGDATQVSRCNIQACPGGPQRAKGSVIGNINDVEFGIAFLNATVTDSPTSDTRIIHAKITNVPRSLGTAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILRMTHIARGLDSDGSLLLDIVVSGYVLQLQSPTEVTVKDYTEDYVQTGPGQLYAYSTRLFTIDGISVPYTWNHTVLYDQARGRMPFLVETLHASSVESDYNQLEETLGFKIHASISKGDRSNQCPSGFALDSVGPFCADEDECAAGSPCSHVCHNAVGTYYCSCPKGLTIAPDGRTCQDIDECALGGHTCHAGQDCDNTIGSYRCVVRCGIGFRRTSDGLSCQDINECQESSPCHHRCFNAIGSFHCGCEPGYQLKGRKCLDVNECRQSVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCLDINECEQVHKPCAYQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYHSYNLARFSPVRNNYQPQQHYRQYSHLYSAYSEYRNSRTSLSRTRRTIRKTCPEGCEASHDRCVDIDECENRDTCQHECKNTFGSYQCICPPGYQLMLNGKTCQDVDECLEQNVRCGPNHMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIAANQDLIRLVAYTQDGVMHPRTTFLMVHEEQTVPFALRDENLKGVVYTTRPLREPETYRMRVRALSYSANGTIDYQTTFIVYIAVSAYPY