lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRSCCCEIKRACAWCPLPETWYMRSLHRTGAPHGERSARWEAPSPAMDEQVPVLCEQLVRAVTVMMEPESSQEYRLEALKFCEEFKEKSPLCVPCGLQLSNKSQSPFIRHFGLHILEHVIKFRWNDMAPENKVCLKDSVMDLISHGIRTILEEESHIKDMMARIVVEMIKREWPQHWPDMLNELDSLTRVGEAQTELVMFILLRLAEDVVTFQNLPPQRRRDILTTMTQNMNVLFAFMLNILQQSVQQYQHLKTDPTNSEKAQGMCRVAVAALNTLAGYIDWVTISHIMADNCKLLGMLCVLLSEPELQLEAAECLLIAVSRKGKMEDRIPLLILFGDEAIEYILSVAQMADTETLEEKRYILLKRICQLICTLGTQICALTQNPDLKVNVPGNFNKYLETLLSFTQHPSQFLTSSTMLTWGTLFRHEVLSRDPHLIAAVPDFLRASMVSIVRVGFPSKDNSPSCKYSKLDFESDEEFNNFFNSFRALLGGVVRAACYLDPKTGFRIAKEWLSYQLSAPLDPGPHNSAKPGETPCSMLSTSFLQWEAMTFFCECVISQYFRVVPKEELPVTEGMGLLQQVLNYETMDPLILSFVLTNLSSLIPFISYMSSYMPPVLSKLLDAISFQLPGDTKVSKSRGVMNVRRHANSSLIKVCRDYPELVLPHFEQLHARIKAMLGEEQLLTQMGKCALMEALILVSNQFKNYDKQRAFLEELVSPLVSMWISEETQRAFSGPNEFISFVGADILASQQEEEDRGGPNRSQLGLCTFTLLAMVKRSQWPTDLEEAKAGGFLIGYNPSGAPLFRNPCAGILLKVLDSLLALIRTMNSLYLPEVMSKMGDTFCKSLNMLEMDKKILTGSSQPTIEDYDFPVKTILSRIQVFFASLFDSCHHILGNCGPSIPHEFYSIPNMTSHLLSSVFTNLDNVPDYRLRIILRVFVKPFIISCPPEKYESLVCPILGPLLVYLHQRLSRKWLSINQRTTVSEEDYTEEDSESQEVLEEQLARVLTREVVDLIGSCCIARKGVDFCASTADVGHSAGQADGDDEEMMATEAVVPGTIELTELGQFLVGNEEISTALLVISYSPLVWKDTIACQRAASQLCWPLLKQVMSTSLPADAALCLFSNILCGLQAHGQHESCKFPLLQLAFQTYEALRPQYQELRGLMEQVPDIQRDSLEQFDTKLLSPQLKASEKKRREQFRKLIAGCIGKPLGEQFRKEVHIRNLPALLKKKTRPALDSESVLSSCDGSLMALFQP
The following text describes a protein:
Function:
May play a role in ribosome biogenesis and in determining the rate of cell division. Involved in a process essential for nuclear and nucleolar functions.
Subcellular Localization:
Nucleus. Note=Does not localize in the nucleolus.
Sequence:
MAEEQEIVDSLSAEVNPDQKVDMEVETATPKAETGDEKREREETEEEENGGESKKQKVGEEEKSGPVKLGPKEFVTSVAMFDYFVKFLHFWPTDLDVNKYEHMVLLDLIKKGHSEPEKKIGGGIKTFQVRTHPMWKSRCFFLVREDDTADDFSFRKCVDQILPLPENMKTPGANGNGHGGGRGGGGGRRGGRGGGRGGRFRR
The following text describes a protein:
Function:
Serine protease required during eye development.
Sequence:
MEQGGKRTRGAVPMVCLSCPVMLLLLQLAGGAPIGQGLYPMPASVLQALSSRGTLVLEAALRSALMALEEALAEQQKQRGACGLCAPCLFPPCANITQRCPPPAVPPAMPPSCQALLDAQELPELPQRHWALSQACSPYLRLCPLQGTQPACTLLSAQRCQHRLQECLLAKAAPNPSMAAAMPERCGSREDPPPNSTAPRGRIMGGNVARHGAWPWLVSVRLHGELVCGGVLVSRAWALTAAHCFNGNQNELAWTVVVGDHELGKADPGERAVPVRRIVPHPKFNPKTFHGDLALLELAEPLAPSGTVSPVCLPSGTTEPSPGTPCHIAGWGSLYEEGPSAEVVMEAQVPLLSQETCRAALGRELLTSTMFCAGYLSGGIDSCQGDSGGPLVCQDPSSHSFVLYGITSWGDGCGERGKPGVYTRVAAFADWLSLQMNPVPGSREPSCFDLLALSQLAPEQQPLERTRLCSFYERSCRAAPGQASCTHIADETCRARLRRCELHSYTQTLVGLLRRAGDFIRNQLDFSFLTRTLPQLLGKIYGHLFPARVRRDAPDPAMAEHPTSEGPLRPPHRQLPTFREFFGSVGPRLQDWVQALRATAGGSAQAPTPDGEQLPEETWLFLQQGEELVEELLGQGRAFLTQLRAELDLDTSLEVMQTPGEPTEGPVGNPVLNWSVLREKRELVPTVPGLEEEEGEKAGTGRACPGLNASALRVGVVQELYAWVLQVPQPDLAMTFQEILVDLSSKNTKGLYRAQVRATVGGRPTAFTGLVGLESDSLARSMPGLVALALEALKT
The following text describes a protein:
Function:
Methylates large ribosomal subunit protein uL3 on a specific glutamine residue.
Sequence:
METSHNQELVATILEDNVANELQTIQDFLRWTYSILNRSDIYFGQGHDNPWDESLQLVLSSLHLPIDLPTELFNSRLTPSEKETLVQLVLTRIEQRVPVAYLTNSAWFCGHEFYVDERTIIPRSPISALIQDRFEDLISQEPNHILDLCTGSGCIAIACAYAFPNAEVDAVDLSVDALNVAEINISRHQLEHRVFPIQSNLFENILGQKYDLIVTNPPYVDEEDLADMPEEFHFEPELALGSGSDGLNITKQILKQAPDYLTENGVLVCEVGNSMISLIEQYPDVPFEWVELKNGGLGVFAIQRKDLVKYHDLF
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
Sequence:
MMLTALGLMSGTSLDGVDVALIETDGKQVKAFGPSGYRPYSPVERNLLRQALSEAVHLTRRDARPGILAEAERAVTQAHAEAVAAFVAQNRMRPEDIDIVGFHGQTVLHRPEKRLTVQIGDAPALARAIHIPVMHDFRAADVEAGGQGAPFVPVYHRALAQSLEREGPIVVVNIGGVSNITYIDGNDTLIACDTGPGNALLDDFMYRTMNQAFDTEGKFAALGTADEAWIARALELPFFALPPPKSLDRNDFAALKLGDVPPAVGAATLTAFTAAAIARIIPLLPRRPRSWIVCGGGARNLTMLRMLRERVGSATVEAAEALGWASDAIEAQAFGFLAARGLKGLPLSYPATTGVPMPMTGGVIARP
The following text describes a protein:
Function:
Involved in maceration and soft-rotting of plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MATFKYLSNFLIAISFFVLAIDATPLVHKRAGRTSAPAGCLTVRGSGTHSGEYSTVGAALSALGSSKSAACIFIYSGTYNEQLTIKYGGNLTVYGYTTDIGTYKSNTVKITHGINSTTIGLDASSTANIVSANFKAYNVDFANTYGAGVQAVAVTANGDQQGYYGCSFTGYQDTLYAKAGKQYYSNCYIEGAVDYIFGDAAAWFGECTIASNGGGAITASSRTLSSDSGWYVIDSSTITQADGYSLTGKVYLGRPWRALARVIFQNSVLTAVVNPAGWTTLAADATPIFMEYANTGAGSSTSARVYETAATGTVNKNTLWGNTWASWVDTSY
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
Sequence:
MMKYINNLKEIEQKVKRICDHFSVNSPDILIVTKYVGKEEIHNIHSLDNKYHFGENSVDSLIEKSEQLAKNIKWHFIGNLQSNKCKNILKVKNLYMIETLDKEKKATLLNNYLKIENELNNNNEELRKLCVLMQIKTTDDETKTGLTHQNYDEIENTVLHIINNCQFLIFKGLMTISSLDINKRENSFVILNDIKRKLLSNQVINNYFLNKTFHMSMGMSDDMELAIKHETTQLRIGRAIFN
The following text describes a protein:
Function:
Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.
Sequence:
MAEQSDKAVKYYTLEEIKKHNHSKSTWLILHHKVYDLTKFLEDHPGGEEVLREQAGGDATENFEDIGHSTDARELSKTFIIGELHPDDRSKIAKPVETLITTVDSNSSWWTNWVIPAISAVVVALMYRIYTAED
The following text describes a protein:
Function:
Dehydrogenase; part of the gene cluster that mediates the biosynthesis of fumonisins B1 (FB1), B2 (FB2), B3 (FB3), and B4 (FB4), which are carcinogenic mycotoxins. Within the pathway, FUM7 is involved the addition of the tricarballylic moieties to the carbon backbone. FUM7 dehydrogenase removes the C-3 hydroxyl of citrate to form tricarballylic acid either before or after the CoA activation by the FUM10 acyl-CoA synthetase and FUM14 catalyzed esterification of CoA-activated tricarballylic acid to the C-14 and C-15 hydroxyls of the fumonisin backbone. The biosynthesis starts with the FUM1-catalyzed carbon chain assembly from one molecule of acetyl-CoA, eight molecules of malonyl-CoA, and two molecules of methionine (in S-adenosyl form). The C18 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of alanine by decarboxylation, on the carbonyl carbon of polyketide acyl chain. This step is catalyzed by the pyridoxal 5'-phosphate-dependent aminoacyl transferase FUM8. The resultant 3-keto intermediate is then stereospecifically reduced to a 3-hydroxyl product by reductase FUM13. Subsequent oxidations at C-10 by the cytochrome P450 monooxygenase FUM2, C-14 and C-15 by FUM6, FUM12 or FUM15, tricarballylic esterification of the hydroxyl groups on C-14 and C-15 by acyltransferase FUM14, and C-5 hydroxylation by 2-keto-glutarate-dependent dioxygenase FUM3 furnish the biosynthesis of fumonisins. The tricarballylic moieties are most likely derived from the citric acid cycle, and their addition to the carbon backbone may involve FUM7, FUM10, FUM11 and FUM14 (Probable).
Sequence:
MSLDHHQFHQANSRNSKPYISYGIPFWRACAHHAKALNSHRIYIVASRSLSRSQALEDLKNALGLIHIVGEYNGIAQHTPWEQVFGLLRDLRQTQADLIITLGGGSVTDGVKLARLLAANNVTTLEQADSLLSHCEPGKPKPSDETVQPASIPVINVPTTLSGAEFTRAAGATNTQSDHKKRIIIHQSMYADIVVLDPELSLGTPARFWFSTGIRAVDHFVEGIYGNMATTMVQGDNSGSDQLIIEKDIQASLGALLVALLHTKDDWQNCDARLRQMLALKDCPRAGHNGVGASHGIGHQLGPFGVGHGETSCIILPCVLKYNWSHGDARLRAKLQLITDVFWGNAVLTKLLVDRGLHPQDTDPGDVIAAYISALGMPNSLAKYGIHEAQFHQIAENAMEDVCTQVNPVELDKNKVVEILYMAA
The following text describes a protein:
Function:
Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the oxidation of the hydroxy group of 4-hydroxy-2,2'-bipyrrole-5-methanol (HBM) to yield 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC).
Sequence:
MVNDTFEQALQNAINIARLAPSSHNCQPWSVHYDAATRCGEVSIDRQRALKGLPSLEREMLMSCGIFFEYLSTLLKHSGYPLDWQWVGARQNGSSGMLISFAPSAPCVADLVAYQQWVQRISDRHTVRTAYQPTQVNEQQQAQLYALFDRSPVTCDIKYGEATRHDVAFLTANYASLDFADQQAWRETYHYIRFNEQQAAEDGFYLHHLFGPVSCGFRWFFRIAFHPRLSWLAKRLRLPASMAKGLAELVVEGPQYLALSLEHESDENLFIAGMKLGQLWLMLQSWGWSLHPLSVLVQHATARCALADTVRLTGLPVFFARFGQHRQSGIPTPRRAWQRILTTTQHSFSPENGADVKQP
The following text describes a protein:
Function:
May act as a cell-binding protein.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MWNRYFVFCLLLLSAFTSQTVFGQRKKGPKSNLLARRSDVQGSICFIDIVFIVDSSESSKIVLFDKQKDFVDSLSDKIFQLTPGRSLEYDIKLAALQFSSSVQIDPPFSSWKDLQTFKQKVKSMNLIGQGTFSYYAISNATRLLKREGRKDGVKVALLMTDGIDHPKNPDVQSISEDARISGISFITIGLSTVVNEAKLRLISGDSSSEPTLLLSDPTLVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPGTHGNPGIKGERGPKGNPGNAQKGEAGERGPGGIPGYKGDKGERGECGKPGIKGDKGSPGPYGPKGPRGIQGISGPPGDPGPKGFQGNKGESGPPGPYGSPGAPGIGQQGIKGERGQEGRPGAPGPIGVGEPGQPGPRGPEGVPGERGLPGEGFPGPKGEKGSEGPTGPQGLQGLSIKGDKGDMGPVGPQGPMGIPGIGSQGEQGIQGPIGPPGPQGPPGQGLPGSKGEVGQMGPTGPRGPVGIGVQGPKGEPGSIGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKGQPGPKGDEGKKGSKGNQGQRGLPGPEGPKGEPGIMGPFGMPGTSIPGPPGPKGDRGGPGIPGFKGEPGLSIRGPKGVQGSRGPVGAPGLKGDGYPGVPGPRGLPGPPGPMGLRGVGDTGAKGEPGVRGPPGPSGPRGVGTQGPKGDTGQKGLPGPPGPPGYGSQGIKGEQGPQGFPGPKGTMGHGLPGQKGEHGERGDVGKKGDKGEIGEPGSPGKQGLQGPKGDLGLTREEIIKLITEICGCGPKCKETPLELVFVIDSSESVGPENFQIIKNFVKTMADRVALDLATARIGIINYSHKVEKVANLKQFSSKDDFKLAVDNMQYLGEGTYTATALQAANDMFEDARPGVKKVALVITDGQTDSRDKEKLTEVVKNASDTNVEIFVIGVVKKNDPNFEIFHKEMNLIATDPEHVYQFDDFFTLQDTLKQKLFQKICEDFDSYLVQIFGSSSPQPGFGMSGEELSQSTPEPQKEISESLSVTRDQDEDDKAPEPTWADDLPATTSSEATTTPRPLLSTPVDGAEDPRCLEALKPGNCGEYVVRWYYDKQVNSCARFWFSGCNGSGNRFNSEKECQETCIQG
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.
Sequence:
MYRGMKIPAVAALAFVLTRVSLASPGYWAHDCDGNYTVPSSYQKSLEQLSAGLPDAVSSSPDLFDKKVLGSWGSRVYGLGRCRPGTDASTCKACLDEAFQEAQVICPLRKRVYMYYEVCTLAFADEDLPSHSAVHKVATKVNGSQVPAQCSKVFDMAINELITYLVKMAAVSPHMSATGQKELAGGACTYSIYGLAECFPKMSAANCSDCLEDLLVVPFLHGHQSEWRSSLTCSYRLEPRPLFDVGKGGLATPGGKNGKKQVWIVVGCVAGALIILLVLLLLWWKLPAKRPSAIKFFDDIIANVQGKTIVMFLDYDGTLTPIVKKPERAFMSEQTRNAVRELAMAFSTSVVTGRSCEKAKGFIQLDELHYAGSHGQDIQLNDGTDPFQPNSEYLQIIAEATERLKEAVREIKGASVENNKFCVSVHYREVRREKDKDLLKNIVMRIVTEEFPNLKVTNGKKVREVRPGPKFDKGDAVKYLLQQLTNKHSWDSSRILPIYIGDDKTDEDAFKVLSEEGGFGIRVCKWRKRTAAEYSLKNPSEVKEFLEKLVRWRREQDQV
The following text describes a protein:
Function:
Catalyzes the alpha-ketoglutarate-dependent hydroxylation of taurine yielding sulfite and aminoacetaldehyde after decomposition of an unstable intermediate. Is required for the utilization of taurine (2-aminoethanesulfonate) as an alternative sulfur source for growth in the absence of sulfate. To a lesser extent, pentanesulfonate, 3-(N-morpholino)propanesulfonate and 1,3-dioxo-2-isoindolineethanesulfonate are also desulfonated by this enzyme in vitro; however, desulfonation by TauD of organosulfonates other than taurine seem to be of little or no importance for sulfur metabolism in vivo.
Sequence:
MSERLSITPLGPYIGAQISGADLTRPLSDNQFEQLYHAVLRHQVVFLRDQAITPQQQRALAQRFGELHIHPVYPHAEGVDEIIVLDTHNDNPPDNDNWHTDVTFIETPPAGAILAAKELPSTGGDTLWTSGIAAYEALSVPFRQLLSGLRAEHDFRKSFPEYKYRKTEEEHQRWREAVAKNPPLLHPVVRTHPVSGKQALFVNEGFTTRIVDVSEKESEALLSFLFAHITKPEFQVRWRWQPNDIAIWDNRVTQHYANADYLPQRRIMHRATILGDKPFYRAG
The following text describes a protein:
Function:
Catalyzes the trimethylation of 'Lys-116' in calmodulin.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEHGEEPSLCAESAKVIARTRWKLLAKVLHKTEKENDESSSHHLVVPTTTSRELYGLFEWAESESKVFWQDNCGQWLQCRSFNHPHFSLNVRFLINQFSIDELTGFNNTGNVCVWPSEEVLAYYCLKNNYVFKEKAVLELGGGMTCLASFAVAKTSDAILVACTDGNPASVENVKRIIEHNNLSSTCPITAQVLDWKNESSFREMESMWDVILCADCLFFDDGREALVDTMQRITTNNGLILIMAPRRGRTLDAFLELCQGKFDIYLDEEFDGDVTLSHQKKLLSSDYNSDHNYPLLVQLRKR
The following text describes a protein:
Function:
Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD(+) and NADH. In Salmonella it is required for resistance to antimicrobial peptides.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripherally bound to the inner side of the inner membrane via the TrkG and TrkH proteins.
Domain:
The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).
Sequence:
MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRSLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNMVACQVAYSLFNTPNRIARIRSPDYVRDADKLFHSEAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKAYYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGGGNIGAGLARRLEKDYSVKLIERDQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAKRMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHGDESTSRVVGRVIDEIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPFFL
The following text describes a protein:
Function:
Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQLPETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGDQIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKLPEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
The following text describes a protein:
Function:
Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation. Plays a role as a negative regulator of the protumoral factor NUPR1.
Subcellular Localization:
Nucleus.
Sequence:
MEPAAPTVQPRAQPPPPDVWPPVGSEEEFYDCPDYYYLRDFPACGAGRINGRTRRERELRTNWLVPGGHERKIAQKLLNSQRKRRQRQLQPRPRTRLT
The following text describes a protein:
Function:
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.
Sequence:
MSDFIGAIDLGSTKVAVVIANLSEKNEELELIGFSMIPSKGISYGVINDIQEASACIKEAVQRAVRMAGIRSIPKMIATISGEKITAIPSRGMIIVKSREQEVTESDVRRAIEAAKATSIPEDREVIYHVVRGFRLDGQNGIMNPIGMIGTRLESDLLLVTHDKVQLRNIINAFQKAEINIEGFIPQEIAASEAVLTPEEKNLGVVLVDIGGDLTNLAVFKEGYLYAIGILKLGGERITKDIAITLKIPTEEAERAKKIIGTLKEEKEESLEVMSLQQKRIKINTSQVREIIQPRVEEILDFVLKKLEELNSPIELIPGGIVITGGTALLDGLEEFAQEYLKVPVRVSRSLRVYNIFEEKDAVFYSSAVGALERITRTVSTDESSKNFLDYLKEIFKNIFSPFKE
The following text describes a protein:
Function:
Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (By similarity). Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKTKKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLVTEVYYNFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQSPVSKLTFKFFLAIFCSFIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESIPLMTEATFDTLRLWLIILLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESISTLPVDNSLLSNSVYSELPSAEGKMKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA
The following text describes a protein:
Function:
Positive regulation of toxA gene transcription.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MTATDRTPPPLKWLCLGNRDANDGFELFAHGIYARNGALVGSKLSLRERRQRVDLSAFLSGAPPLLAEAAVKHLLARLLCVHRHNTDLELLGKNFIPLHASSLGNAGVCERILASARQLQQHQVELCLLLAIDEQEPASAEYLTSLARLRDSGVRIALHPQRIDTDARQCFAEVDAGLCDYLGLDARLLAPGPLTRNLRQRKSIEYLNRLLVAQDIQMLCLNVDNEELHQQANALPFAFRHGRHYSEPFQAWPFSSPAC
The following text describes a protein:
Function:
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Sequence:
MPVARSSKAQSSKQPRASKAPSVTENVPPEKEEGCQAKRSPSSPQGGPKKRSAFGDITNAHKNQVVTGKKEGVKAPTRKATRAPPAPIVAKNNEINLKKSLRKTPPADVPVEPEKDSVPEEPVQQVPVVEDIDKEQLGDPYANAEYAKEIFDYMREREEKFLLPDYMEKQSDISRDMRAILVDWMVEVQENFELNHETLYLAVKLVDHYLVEVVSMRDKLQLIGSTAVLIASKFEERCPPCVDDFLYICDDAYKREELIAMETSILRTLNFDINIPIPYRFLRRFAKCARASMETLTLARFVCEMTLQEYDYARERPSKLAASSLLLALTMKNLGGWTPTLEYYSGYCAQDLHPLVKRLNFLLTYQPCDKLKAVRTKYSHRVFFEVAKTTPMDMMKLEEKLKS
The following text describes a protein:
Function:
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine (GlcNAc) residues in chitin. Shows activity towards the chitinous oligomers GlcNAc(3), GlcNAc(4), GlcNAc(5) and GlcNAc(6), but not GlcNAc or GlcNAc(2). Requires the substrate to occupy subsites 0, +1, and +2 for optimum catalysis.
Subcellular Localization:
Secreted.
Sequence:
MKRLSVLCSLLLVAAALGTELPLATPCDEEACKLPDCRCSSTNIPGGLRARDTPQFVTVTFDDGINVINIETYREVLYGRSNSNRCPAGATFYVSHEYTNYQLVNELYNRGFEIALHSISHRTPQAFWADATYQNLVQEIGDQKRQMAHFASIPASAIKGVRIPFLQMSGNTSFQVMADFDLLYDCTWPTTALTNPGLWPYTLHHESIQDCIIPPCPTASIPGPWVLPMISWRDLNNFPCSMVDGCFFTPDRTDEEGWFKFILTNFERHYLGNRAPFGFFVHEWFISSNPAIKRAFVRFMDIINNLNDVFMVNSAEVIDWVKNPVPIDRYRQQQCKFTMPSICRPSFCGPLTGTHNQLSYYMTICNTCPRNYPWVGNPLGQ
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MKWGINMLNREIINALLDIKAVELRVDKENWFTWASGIKSPIYCDNRLTMSYPKIRKQIAEGFVKKINELYPNVDYIVGTATAGIPHAAWISDIMDLPMLYVRGSAKDHGKTNQIEGKFEKGKKVVVIEDLISTGKSSVLAAQALQEEGLEVLGVIAIFSYNLNKAKEKFDEAKIPFSTLTNYDVLLELAKETGLIGDKENQILIDWRNNL
The following text describes a protein:
Function:
Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron; Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity. Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MTLRRASGCRQLTLTIGLALTLGLLQWPIGDVRGQDGASPAQVLQELLTRYGDNASISVPQLRSLLVRLNGGQSEDHDSKTQPTRTNASKCLAADTLAVYGMSEQSRIDERGLQQICPTMIQQLDSQACKTQPNQESESSPRPTEAEVWGYGLLCVTVISLCSLVGASVVPFMRKTFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFDPMEDYYVPKSAVVFGGFYLFFFTEKILKMILKPKDTGGHGHGHSHFPAERYANSNGDLEDGVMEKLQNGEAGGAALPRAEADGRGVGEDDKMLSTGQTVQDTQSSGGGGTGGCYWLKGRAYSDIGTLAWMITLSDGLHNFIDGLAIGASFTASVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGMGFGILAGNNFSPNWIFALAGGMFLYIALADMFPEMNEVSREEEEAGGSGFLLTFALQNAGLLTGFAIMLVLTIYSGQIQLG
The following text describes a protein:
Function:
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
Subcellular Localization:
Cytoplasm, perinuclear region. Lysosome. Nucleus.
Sequence:
MSVQSEMGDWLQRPRMSSLCCIQPIVSQLTALARRLCSCAGRDRRAWLRSPPAVTVQKLPVCEVFQGELEMVDHLANTEINSQRIAAVENCFGASGQPLAVPGRVLLGEGILTKECRKKPKPRIFFLFNDILVYGSIVINKRKYNSQHIIPLEDVTLETLPDTLQMKNRWMIKTSKKSFVVSAASLTERKEWISHLEECIRHLLTKTGRQPSTEHAAPWIPDKATDICMRCTQTKFSTLTRRHHCRKCGFVVCGDCSRQRFLMPRLSPKPLRVCNLCYRQLLAEQKKEEEADCQQPEQYRSAIPGYEPSSGDDSDKSDDYKVDQWPADTEFYTSEVSWSSFHS
The following text describes a protein:
Function:
Binds to heparan sulfate proteoglycans on the surface of fibroblast (NIH-3T3) cells.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKASSGKPREFRPAVLLLILGLLLRDSRGSSIQGFLADVEVHGSSRLTRTHTLRYNVRAHSLEGSEKTQLLVLIYVDEELFLKYNGDSRETEPLGCWIKGHGGNETCARETNNLLKVEEKLRGMMAEVINQKSQEEGLHTLQATLGCELLSNGSTRGFWHLGYDGQNFLTFDQKTLTWTVDGPSTQQNKMFWKTHAPRADLVKTFLDDICPAHLQRYLASLRNGLQDTGPPMVTVTCRNYPVGRVTLTCRAFNLYTREATLVWLQDGKPVQQKTFRSETILPSGDGTYQARVSIRVLPGQEPQFSCNLRHGNHSIMQTAVSGHAAEDSQDVASSATASAGSALPVVLAVALARAN
The following text describes a protein:
Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Nucleus membrane; Multi-pass membrane protein.
Sequence:
LTMSLDARDALGVNASSPRLAPHDGELPANLSNGTSGNQTLFPSLDVTRAAALGIVLGAFISFAIVGNILVILSVVCNRHLRTPTNYFIINLAIADLLLGTTVLPVSATLEIVDYWVFGRVFCDIWAAVDVLCCTASIMSLCVISIDRYIGVRYSLQYPTIVTEGRAVLAMLGVWGLSLVISIGPLLGWKQPAPPDEKVCVITEEPFYALFSSLGSFYIPLAVILAMYCRVYIVAKRTTRNLEAGVMKERSNAKEFTLRIHYRGSQASEEGAGAGRGRAQHIRSSLTVRLLKFSREKKAAKTLGIVVGMFILCWLPFFLALPIGSFNTHLRPPETLFKVIFWLGYFNSCLNPIIYPCSSKEFKRAFIRILRCQCRRRKRPGWKASNYRTSHLDSSDYSRKDSVDSIFFNGSQRRLSSPSPSCLCIGPDRHHEPGAPHAWRPCASSLPGSPTDSQLRPLAG
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRSAVREEHQEMEALEQYRAMLDVAIAEARTGLGEDGIPIGAALFDAGGQLLGRGRNRRVQENDPSVHAETDAFRKAGRQRSYRDTIMVTTLAPCWYCSGLVRQFNIGTVVVGETVNFQGGVAWLRENGVQVVDLQSRECADILSSFIAANPAIWNEDIGHDLETPNPNSSGAGP