lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSSPSPSLKKRRVSKKRKSSWRKHSSKKEVEEYLENKRLDDRTGGPISEKDDEEIFFFGKEATKEEVPDRRSRRQSRSAECHSSIHSLDSHIKPIKSSRAPKENPKAKLFELKYKDPLDVDDGGEMKFYDIWHKKDDSGFPEGDVFVHSRRVCRKMPIKPPRNFGKKSSAAGAIPLPHPGISYNPSFQDHQKVLSDVLEAELKKEKEERRIYNATDAMFPTKDEMPTQETWLEEMSQGLGGIMPGRSNDDEDDDDDDEKEGNRIGISHNAPVRRDNKKTERERKKMMKVRVAEKELRRKKKMEALEKSEKFKLKSLKKQLHRQEMERAARKTRKEWMNEKRMMTRPRKLGKSRFVEPQPPIKLTDELEGSLRLLKLQYLIFIYLKWCRKPKRYRPKVFEKSSYKDVDK
The following text describes a protein:
Function:
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions.
Miscellaneous:
MISCELLANEOUS: 'Motus' means 'motility' in Latin.
Subcellular Localization:
Cell junction, tight junction. Note=Localized on the cell surface. May act as a transmembrane protein.
Domain:
The coiled coil domain interacts directly with the BAR domain of ARHGAP17; The angiostatin binding domain (871-1005) allows the binding to angiostatin.
Sequence:
MRNSEEQPSGGTTVLQRLLQEQLRYGNPSENRSLLAIHQQATGNGPPFPSGSGNPGPQSDVLSPQDHHQQLVAHAARQEPQGQEIQSENLIMEKQLSPRMQNNEELPTYEEAKVQSQYFRGQQHASVGAAFYVTGVTNQKMRTEGRPSVQRLNPGKMHQDEGLRDLKQGHVRSLSERLMQMSLATSGVKAHPPVTSAPLSPPQPNDLYKNPTSSSEFYKAQGPLPNQHSLKGMEHRGPPPEYPFKGMPPQSVVCKPQEPGHFYSEHRLNQPGRTEGQLMRYQHPPEYGAARPAQDISLPLSARNSQPHSPTSSLTSGGSLPLLQSPPSTRLSPARHPLVPNQGDHSAHLPRPQQHFLPNQAHQGDHYRLSQPGLSQQQQQQQQQHHHHHHHQQQQQQQPQQQPGEAYSAMPRAQPSSASYQPVPADPFAIVSRAQQMVEILSDENRNLRQELEGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLRERLETANKQLAEKEYEGSEDTRKTISQLFAKNKESQREKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNCQPTNVSEYNAAALMELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSCMRPAKSLMSISNAGSGLLSHSSTLTGSPIMEEKRDDKSWKGSLGILLGGDYRAEYVPSTPSPVPPSTPLLSAHSKTGSRDCSTQTERGTESNKTAAVAPISVPAPVAAAATAAAITATAATITTTMVAAAPVAVAAAAAPAAAAAPSPATAAATAAAVSPAAAGQIPAAASVASAAAVAPSAAAAAAVQVAPAAPAPVPAPALVPVPAPAAAQASAPAQTQAPTSAPAVAPTPAPTPTPAVAQAEVPASPATGPGPHRLSIPSLTCNPDKTDGPVFHSNTLERKTPIQILGQEPDAEMVEYLI
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MEFPFKVNELFRDDISIIDCHLIPRGVQVVSSKQSKYKDYVGIIIDELGKASAEAQRLTCEITSKEKLLNTDNRIYLKVDRGKNRVIGYIKVGTKKLFLFDTAHNQHELEPICVLDFYVHESMQRKGCGKELFDFMIQASVRDLSENIRPCDLAINRPSEKFLAFLGKHYSLSRIIPQMNKFVIFDNFFDGREIPVNRRQWNYDDNLDDDEDNDIHSYHHHHLKHQQKLHHHKSAPVSSYGQHRQQLQQQQSPQQSPQQQQNHHYQERSPQVPPSSLTSTGRVEHTFTNKSSPANSSSSCSNNNNSSTIELQTTAYNHKHTDSSFNIFGVQRAMSNLVINTTTATPERNIHDHDRNFGSNCISRSSFNVNAGSGNNNTRVNSSSRRSNTIFY
The following text describes a protein:
Function:
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Sequence:
MADQDARNGEDKRPTGIPALRWEEPPEGPVLVLLDQTRLPAEEVELVCTDPAALVEAIRSLAVRGAPLLGIAGGYGVALAAVRGFEVEEAAAALAGARPTAVNLAVGVRRAQAAHREALAGTGDTRQAARAALAAARALHREDTEASARMAAHGLALLDELLPAGGHRVLTHCNTGSLVSGGEGTAFAVALAAHRSGRLRRLWVDETRPLLQGARLTAYEAARNDMAYTLLTDNAAGSLFAAGEVDAVLIGADRIAADGSVANKVGSYPLAVLARYHHVPFVVVAPVTTVDPDTPDGASIEVEQRPGYEVTEVTAPQVPVAGAGGGIPVAPLGTQAYNPAFDVTPPELVTAIVTEEGVVSPVTTEALASLCARSRQVTIS
The following text describes a protein:
Function:
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (By similarity). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Nucleus outer membrane; Peripheral membrane protein.
Sequence:
MDDSEKDFNLKVVLVSFKQCLTDKGEVLLDHYIAGWKGLVRFLNSLGAVFSFISKDVVAKLQIMERLRSSPQSEHYASLQSMVAYEVSNKLVDMDHRSHPRHPHSGCRTVLRLHRALHWLQLFLDGLRTSSEDARTSTLCSEAYNATLANYHSWIVRQAVTVAFCALPSRKVFLEAMNMESTEQAVEMLGEALPFIEHVYDISQKLYAEHSLLDLP
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MDPSIIEFIGEKCMISIIPNFSNEPLHLIYGPVGPFRAGFPVFVPLWMATHLRKQQKCRIVPPEWMDMDILEEIKEEEKRSKFFTKMPCEHYMVVAQLVMSTAPDDVPRCEELRTVIKDIFDIRESKLRTSIDAFIKGEGTYAKLDNLTLLEIHSVRPILPYSLDHIARYQRTATASQRDTSMLSASMAGSSSGPNSNSLFSQ
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEEDYGVFILDVEGTVCPIAFVREQLFPYFLDKVEELINNADETERDLLADMQSRHGGAAAASLLRQLVAEDVKDPALKALQGRVWERGYASGEITAPVYADAVRFIQRNAGRVYIYSSGSVQAQRLLFGHVSNPSGDGVLDLTGHLAGFFDIPAAGRKTEAKSYERILAAIGLERQPGAAIFVSDSVAELDAASASGLSVRLAVRPGNERVSGARYTTLTDFEGL
The following text describes a protein:
Function:
With imt1 and imt3, is required for the synthesis of mannosyl phosphorylinositol ceramide (MIPC). Catalyzes the addition of mannosyl to phosphorylinositol ceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MVKVIYKFAVFAAVNFFLMSSIVLYFNNEFLMFADRCTKDIIPSEELRYLRQVLNDSIPSKDEPLPTLKLDSLNDISGEPVIPKIIHQTWKTTEVPEGWKGAQQSCIDLHPDYEYILWTDEMSRNFIADNYPWFLPYFDAYPFNVQRADVIRYFVLYHYGGNYIDLDDGCRQRLDSLLYYPVWVRRTDPVGVSNDVMGSVPHHPYFELIIQNLEKNAKSYWLPYLTIMLSTGPLSISFLWEKYKRQLPNPPAFYDHIRVLLERDYKFSNDSYFTFYEGSSWHNNDAGIILWANRHLAYVIVAGFCLYFILSYMFFSKLLDSRYVQRFVTSKRKQPTLPLALQEDV
The following text describes a protein:
Function:
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MPTKIAVYPGSFDPITYGHLDIIDRALRIFDQVIVAVARNSAKSALFTTDERVDMIQRVLADNVRARVDTFDGLLIDYVLSQKATVIIRGLRAISDFEYEFQIAQMNRSISQDVETLFMMTSVPYGYLSSSIVKEVSSLNGPIDGLVPPLVRQALRDKFAGPDR
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Miscellaneous:
MISCELLANEOUS: Was called L10e in this organism; in this case 'e' is for E.coli-like, not eukaryotic-type protein.
Sequence:
MKRLALALKQRKVASWKLEEVKELTELIKNSNTILIGNLEGFPADKLHEIRKKLRGKATIKVTKNTLFKIAAKNAGIDIEKLEQYLTGPNVFIFTKDNPFITNMFFENYKLRRYAMPGDKAEEEVVIPAGDTGMPAGPILSVFGKLKVQTKVQDGKVHVVKDTVVAKPGDVIPAEALPILQKLGIMPVYVKLKIKVAYHEGLVIPAESLKLDLEGYRSNITEAYRNAFTLAVEIAYPTPDVLKFTISKVFKNAIALASEIGYITPESAQAVISKAVAKAYALATAIGGKVDLGVQLPTVQQSQSQQPAAEEKKEEKKEEEKKGPSEEEIASGLASLFG
The following text describes a protein:
Function:
Probably functions as a manganese efflux pump.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSTISVLITALALSMDAMSLSIYQGIASTESQKKQNFLKIVLTFGIFQFAMALVGSLSGILFIHYISLYSKYVSFAIFLFLGLMMLKEALKKEEMEYDEKYLDFKTLIIMGIATSLDALLVGLTFSILPFYQTFLYTVEIGVITAIIAGLGFILGDKFGNILGQKSHFLGAALLIFISINILL
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKPDLLGPQCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAITRTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGLRGSAKIWSKSN
The following text describes a protein:
Function:
Key component of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. RqcH recruits Ala-charged tRNA, and with RqcP directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal alanine extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
Sequence:
MRLKLSFDLLTLELFYEETKDLILNSIVEKIYQIGNTDIFLELFSPNHGRFKLILSVHPQLYRIQITKKEFPYPVRPPSFLMLLRKHLEGGRIINYSLVPQERIVEFKIKRFPEEDKKLILELMGKYSNLILLNENHIIIDAIKHISSEVSRFREILPGISYIYPPKTQKISILDLNEERLDEILNKETSLKDVLLKEVAYMNPQLVNDILGEKDKEKIKKRILEIREKIIKKELTPIVYFHEDEPITFSLFPLKEYETFEKKEFDKIYKAIDFVYSYAFDKTLFEQRQRRLLELVKENIRKVADKIKEFDEQIKEGEDAEKLKIKGEILLFHKDEIKKGVGKIILPNPYNFEEIVEIELDPSLSAFENAQKYFKRYKKLKRGINILKEQRQKLEDELYYLNSLEFSIENAKTFPELREIEEELEKGGYIREPKEIIYKREKSPELLKFLSSDGFEIYVGKNNKQNETLTFQIAKPEDLWLHARGIPGAHVIIKTNNEEVPENTIYEASSLAAYFSKGRYSIYVPVDYTKRKYVNKPKGSKPGFVIYKNEKTIFAKPEDALPLLSQKS
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MHSRGSSNIKNKSEHEDQSHGGYMSEKVRKLEEQFRGDAPTNKEKSGTSTDIFRGVTIHVNGYTDPSSDELKRLMTIHGGMYQHYYSVSRVTHIIATNLPYAKLRQLKTEKIVKPDWITNSIEAGRLLPSLPYELYTDRSSRQNQAVLQFSKGPGVKPDAPSIPAPIPKAAPEKGGSDDVSQEQEDDEGSTLSKADKSLAAVDANVQGRANRSFGIATAGDSNFLSEFYSNSRLHYISTWGAECKAYVNALQSNGDATFPGRQRLLAIMKEGKSQRQAKKCELGVVGTEDDDRDWSEDAMIDPKESEHRATGSSKTTKGKEKMRRIMHIDMDCFFVSVGLIKRPDLVDKPVAVTHSKGQSGMSEHRQEISQFEREYYEKKYGSEAARQNHKEDQSNSSSDAKVTGTGTAGGASSSSSSGKPKETFHSMAEIASCNYVARKAGVKNGMFMGRAKSLCPELQTIPYDFDGYKRVSQKLYDIVASYTHDIEAVSCDEMFVDISGILRDTKASAEEFVQMLRKEIKDQTQCNASAGIASNILLARMATRVAKPNGQFIVEPHAADAFIRTQPVKDLPGVGRSTTRKMETLDIKTCADLQQLSLGAVQKEFGQKTGQLLYGFCRGLDDRPIRQEQERKSVSAEVNYGIRFKQESDSEKFITELAAEVHKRLTAIKMLARTITIKLKVRHPDAPKETSKFMGHGICEDKARSCTLGQATEDVQVIQKESKNLLKELQVPAVDMRGVGIQLSKLSSSAQAGTLPSKSITAFMTKPKPADIAPDPVESTHRDTDQSTSLSSASTAPSGSKPKVRTMLNFVSKRRADAETSADAEVSAVDVIKDSTSKTPRKKRKSILPPLPFIPGPKDLQSSRLSGHLALPSPSQIDMSVLQELPKDLQEQILESYRGQKSKHSASKDTSEPSTSSGITDSSRWDQGVVGSVPPRILEELMQDDPNQGTSSLGVVEALPSFSQIDPSCLEALPAELQEELRSAYRGKQTQAHHELEPEKETRKMETRPETASPAKESPGKSPFKIRKRGRPRKGSPSSKANNPKRPRWQMGIQQIITRIQTPPKLSSGDGRQAEEARLPSDSIPQHLRNEESNPQEERNKIEEELDGMEREIEEEDVNLCGAVHLWDVKVLLKEWIASTDDPVDEDIGFIVQYLRELILDKNLEMVDHVMRSLVRSVKRGGSSPWLEAVDMVIARVQHTLGQIYSAHLKMAPSS
The following text describes a protein:
Function:
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly (By similarity). Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region (By similarity). May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity). May play a role in positively regulating mitochondrial function. Plays a role in fertility.
Subcellular Localization:
Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.
Sequence:
MIIKRLNFSCRLFSTASTSTSYEKTPIQPATKCLQLAVIGAPNVGKSLLTNSLIRCPLSAVSSKMDTTTRNISASICSDSTQLVFVDSPGAVSTSHVRQTMKKTSATSGDRVLQDPERALQRAQHVLVVQDSTAPGAYIHHRVLHMLHRYSHVPSILVMNKIDLVMRRSDLLPLVEILTNGQLSDNQQISTKPAQIGRLGKSLSTNIQSSSSFKPSDEKWQSQFRELIQKPTWKCSYSETRSLFRTICGWSGFERVFFVSSLNGEGIDELRDHLMSISPQGEWKMQDGMPTGESAQQLCIDSIRAAVLDTTPSDVAYTVQIRISEWEEQGEVLQIVGEIRCQKPRDGSLIIGKGGKRISEIGRRVNEHLHSLFQRQLYARLIVTHNGKLITQSK
The following text describes a protein:
Function:
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Sequence:
MAFIEKGQEIDMEVIKAETQLSAEALRLKESRDRELADIISGEDDRILLVIGPCSSDNEEAVLEYARRLSALQKKVADKIFMVMRVYTAKPRTNGDGYKGLVHQPDTSKAPSLINGLQAVRQLHYRVITETGLTTADEMLYPSNLILVDDLVSYHAVGARSVEDQEHRFVASGIDAPVGMKNPTSGNLGVMFNAIYAAQNKQTFLYHGQEVETSGNPLAHVILRGAVNEYGNYMPNYYYENLLQAIERYETMGLENPFILIDTNHDNSGKQYMEQIRIVRQTLQNRDWNEKIKKTVRGFMIESYLADGRQNQPEIFGCSITDPCLGWENTEALVEEIYVTLTK
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGGITAASGGRNIDNGDLLSLQARMKKDPPGYEEELLLQLRHFDACISILLLQAPVQAPTGPTPAGESGPAKEVADVAMFLAHMAPFYPQHLKELPQKLLQVLSNYQSLQPHLRRQLTQSLILLRNRKKVELTQILPILIDLQCVGDRVLRKLAFLHIIHDIRRTNLKHKNEQFNRSAQNLLFNILKGDEEVKAKRALVVLAELHRRKVWTDERTADAICSACLHKSPRIMIASLRFLLGYDQEKEDQEEDESSDEEEDPAKLSVNVDRESIYKAYHKGTVSSKRKKQAKLQRVIRSMKKQQRTHSREMEQGSHAPLQHVVDPQEFAEKLFARLRSCNEKFEVKLMMMQLISRTVGIHRLILLNFYPFLQRYIEPHQRDVTLVLAAAVQACHDLVPPDAIEPVIRQLVNHFVHDRARPEVIAVGLNVVREICMRVPLIMTPELLQDLALYKKNREKAVAAAARSVIAVYRELMPSMLGKKDRGRNADLAAKPKAFGEVSVATGVPGAELLLEDTESENEDGEGSEDEEEDDDDDDEGVLTLEEEESGDEQVTSDLDGEEGEDEDDEDDDEEGDDEDDEGVELTGEETPVRAKKKRKVEGQETPGTPGTPMTPGTPGTPVTPSTGQSLRNLRKQAVSKSIDTSEIKSKDGDGILSNEDYEKIRVMKSKRAAKEALSDHGLTKAGKKRKETSVKLTNPDNLSGRRVDPAVLEAHVKRRMEKEERVAMVKAGREDRTPYSSRTATKQKKTGGMSNKQKNKRKALPLAAVRSKVARNAEMKRMKGRGKNQFRGKKAWKS
The following text describes a protein:
Function:
Subunit of the integral membrane V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MGFLITTLIFVVVGIIASLCVRICCNRGPSTNLLHLTLVITATVCCWMMWAIVYIAQMNPLIVPILSETE
The following text describes a protein:
Function:
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
Subcellular Localization:
Nucleus.
Sequence:
GLTCVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGMCTVDKSHRNQCQACRLKKCLQMGMNKDAVQNERQPRNSAQVRQDQLESELQHHPSPHATISATHPAFNPHKSNHHHHHHRMMSSRSNSRSNQQQQQQQQQSSSSSSSSSSSAVVIYPEGMAPTFYPMGHETMYECSARLLFMAVKWSKSLPSFANLPFRDQVILLEESWSELFLLCAIQWSMPMETSPLFTIPDHPPSNANHPSPLLNSKAHLQAHSDMRILQELSSRFRLLQVDPPEFACHKAIVLFKPETRGLKDPRQVENLQDQAQVMLGQHTRSQYPSQPVRFGRLLLLLPLLRMVPSERIENLFFRRAIGNMPMEKLLCDMFKS
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MAAAAIRGQINVLIATMFNTGLVDDAFLQLQRMREQGRETPAHVVEVMNRFLIDAERIINDITGLMINEPEVDFDKVDGLVQQLKVTCSSVGAKRLNLCCVQHFSPEAKNKEGYLEALGRVRFQFYDLRSMFKIIMELEQHLVACGPK
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MAGSGSGRSLLHFMRLLGQLKRVPRTGWVYRNVEKPESVSDHMYRMSIMALVTEDKNLNKDRCVRLALVHDMAECIVGDIAPADNVPKEEKHRREEEAMKQLTRLLSEDVRKEIFDLWEEYENQASAEARFVKELDQCEMILQAFEYEELENRPGRLQDFYDSTAGVVWGPGWRARHSRKLEKEDWVRPSSPPPREGACRPASSALFPKLSRRQSRAVGRRVSGHSVPQGQRRPNLAEECQATRKGCGPGARRTGFPSSSTAG
The following text describes a protein:
Function:
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MQCRLPRGLAGALLTLLCMGLLCLRYHLNLSPQRVQGTPELSQPNPGPPKLQLHDVFIAVKTTRAFHRLRLELLLDTWVSRTREQTFVFTDSPDKGLQERLGSHLVVTNCSAEHSHPALSCKMAAEFDTFLASGLRWFCHVDDDNYVNPRALLQLLRAFPLARDVYVGRPSLNRPIHASEPQPHNRTRLVQFWFATGGAGFCINRKLALKMAPWASGSRFMDTSALIRLPDDCTMGYIIECKLGGRLQPSPLFHSHLETLQLLRTAQLPEQVTLSYGVFEGKLNVIKLQGPFSPEEDPSRFRSLHCLLYPDTPWCPQLGAR
The following text describes a protein:
Function:
Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a have adenine at position 10 of their guide (g10A preference). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle: antisense piRNA-bound Siwi and sense piRNA-bound Ago3 reciprocally cleave complementary transcripts, to couple the amplification of piRNAs with the repression of transposable elements.
Subcellular Localization:
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MADPGKGRGRSLALLQALKKSQMMDSPSQSESQSPESTPEQSTAPSTIASATPSTSGVSIGGRGRAAALMLAKMQQKPGSTTPAIFVPPSSTSAPTAGTGRGFKLLQNLQASQKASSQIASSQVTSSAQSDIKDLTEKMSETSVSAQASSVAKNKYFREVKDTPPVVKKGETGVPIEVTCNYIYLNFKENIVFEYEVKFEPDQDYKHLRFKLLNEHIEHFKEKTFDGTTLYVPHELPDAVRNLVSTNPYDQSKVNVSIIFRRTRRLSEMIHIYNVMFKCIMKDLKLIRFGRQHYNEHAAIQIPQHKLEVWPGYVTAVDEYEGGLMLTLDSTHRVLRTQTVLSLIKEVVQTEGANWKRKMTDILIGASVMTTYNKKLFRVDTIDDKMSPRSTFEKTEKGETVQISFIDYYKKNYGIEIMDWDQPLLISRDTKRMPGSDTPTDFMICLIPELCQLTGLTDDQRSNFRLMKDVATYTRITPNQRHAAFKKYIESVMKNETAKSRLAGWGLSIAPETVNLTARTLPPETLYFGDNVRVPGKPNAEWNSEVTKHSVMQAVDIMRWVLLFTQRDKQVAMDFLSTLKRNCRPMGIMVSDAELVPLANDRTDTYVLALKKCITSSVQLVVAICSTKRDDRYAAIKKVCCADNPVPSQVINARTLMNTNKIRSITQKILLQLNCKLGGTLWSISIPFKSAMIVGIDSYHDPSRRNRSVCSFVASYNQSMTLWYSKVIFQEKGQEIVDGLKCCLVDALTHYLRSNGQLPDRIIIYRDGVGDGQLKLLQQYEIPQMKICFTILGSNYQPTLTYVVVQKRINTRIFLKSRDGYDNPNPGTVVDHCITRRDWYDFLIVSQKVTQGTVTPTHYVVVYDDSGITPDQCQRLTYKMCHLYYNWPGTVRVPAPCQYAHKLSYLVGQCVHAQPSDVLVDKLFFL
The following text describes a protein:
Function:
Transcriptional corepressor. Negative regulator of jasmonate responses.
Subcellular Localization:
Nucleus.
Sequence:
MSSLSRELVFLILQFLDEEKFKESVHKLEQESGFYFNIKYFEEKALAGEWDEVEKYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDRNDRAKAVEILAKDLKVFATFNEELYKEITQLLTLENFRENEQLSKYGDTKSARNIMYTELKKLIEANPLFREKLAFPSFKASRLRTLINQSLNWQHQLCKNPRPNPDIKTLFLDHSCNAANGGARALTPVNLPVAAVARPSNFVPLGVHGGPFQPTPAPAPNPNALAGWMANPNPSSSVPSGVVASASPFPMQQPNQVNALKHPRPPSNSLGLMDYQNAADHDQLMRRLRSAQNEVTYPAHSHPPSASLDDLPRNVVSTMRQGSVVMSMDFHPAHHTLLAVGGSRGEVSLWEVGSREKIVTEPFKIWNMSACSGVLQGTIVKEPSISVTRVAWSPDGNFIGVSFTKHLIHVYAYQGSDLRQHLEIEAHVGRVNDLAFAHPNKQICIVTCGDDKLIKVWDINGKKLYTFEGHEASVYSICPHQKENIQFIFSTALDGKIKAWLYDNVGSRVDYDAPGQWCTTMLYSADGSRLFSCGTSKEGDSFLVEWNESEGALKRTYVGFRKKSNGVVQFDTTRNRFLAVGEDNQVKFWDMDNTNLLTTIEAEGGLPSLPRLRFNKEGNLLAVSTADNGFKILANADGLRTLRAYEASKASIEMKVSTSAMVSALSPVVGKIEHMDTSSPARPTPIPNGIEAMSRSIEKPRNLESVVDKSKPLELTEIVDPTQCRQVTMPDSKDSVSKVARLLYTNSGVGVLALGANGVQRLWKWSRNEQNPTGKATANLTPQHWQPNSGLLMANDVSENPESAVPCIALSKNDSYVMSACGGKVSLFNMMTFKVMTTFMPPPPASTFLAFHPQDNNIIAIGMEDSSIHIYNVRVDEVKTKLKGHQKHITGLAFSTALNTLVSSGADAQLFFWTADTWEKKKSSAISLPPGKAPVGDTRVQFHNDQVHLLVSHETQLAIYDATKMECIHKWVPQEALSSPITSASYSCNSQLVYASFADGNIAVFDADSLRLRCRIAPSAYMPQPIPNSAPIIPQVITTHPQEPNQLAVGLSDGSVKVIEPSEASRRWGVGVAVTADKSGAENGRPSSSSAANNNSSSDHQMQR
The following text describes a protein:
Function:
Component of the larval cuticle.
Sequence:
MFKILLVCSLAALVAANANVEVKELVNDVQPDGFVSKLVLDDGSASSATGDIHGNIDGVFEWISPEGVHVRVSYKADENGYQPQSDLLPTPPPIPAAILKAIAYIEANPSKN
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MRVVAVSSGFKRFVRLVLRLEIEGGVGRGLNVWDGFTHRYPNKSGSDHGNGDTTCDSYSYWEKDIEALVELNATGYRFSIAWSRIIPRGKRSRGVNQEGVNYYRGLINRLVEKGITPFVTLFHWDLPQALQDEYEGFLDPQIINDFKDYADLCFQEFGANVTNWITINQLYTVPTRGYGFGSDAPGRCSRALDPTCYAGNSSTEPYIVAHHQLLAHATVVDLYRKNYKHQGGKIGPVMITRWFLPYDNNDPESKAATERMKEFFLGWYMFTPSESNRVIIFKKSYQKHKSKYSKFYIRGVNQEDEYEGFLDPQIINDFKDYADLCFQEFGANVTNWITINQLYTVPTRGYGFGSDAPGRCSRALDPTCYAGNSSTEPYIVAHHQLLAHATVVDLYRKNYKHQGGKIGPVMITRWFLPYDNNDPESKAATERMKEFFLGWYMFTPSLQRCVII
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1. tRNAs are then processed by TRNT1.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MSMDVTFLGTGAAYPSPTRGASALVLRCEGECWLFDCGEGTQTQLMKSQLKAGRITKIFITHLHGDHFFGLPGLLCTISLQSGSMVTKQPIEIYGPAGLRDFIWRTMELSHTELVFPYVVHELVPTADQCPTEELKEFAHANKVDSPPKEGQGRTILLDSEENSYLLVDDEQFVVKAFRLFHRIPSFGFSVVEKKRPGKLNAQKLKDLGVPPGPAYGKLKNGISVVLENGVIISPQDVLKKPIVGRKICILGDCSGVVDDGGVKLCFEADLLIHEATLDDTQMDKAKEHGHSTPQMAATFAKLCQAKRLVLTHFSQRYKPVALAREGETDGIVELKKQAESVLDLQEVTLAEDFMVISIPIKK