lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Involved in somitogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MELMMYKCLILLACVCHWVGVVSAEEEVLMNTKTETSDLKWTIFSRSKPEWEEISGLDEEGISVRTYQICQTDSSSSHWLRSGFIQRQGASQVYVELRFTMMECSSRGTHHRSCKETFNLYYYQADSNEATATYPPWMENPYTKVDTVAADFLLRKGGERKFNVKTLRLGPLSKRGFYLAFQAQGACMALLSVRVFFKKCPPLVSALSSFPETVPRTLVQEAQGECVKNAAQQGPRPRPPKLFCGEDGQWVGQPTTSCACLPGYEPTEGQTLCTACPVGQFKSSTEGQCQSCPGFSHATSRGASVCACRPGFLRAQSDPPNSSCTKTPSAPRGINPRINATTLTLEWNEPLDSGGRTDLSYSVRCSICRSPKSPCQPCKDGVIYRPAQEDLLVRRVEVWDLLPHTTYTFTIQALNGVSKLSNKEPASESINITTNHEVPSLVSVIRKSDSTESSLTLHWSVPAQPRYNVLQYQLRYCEKDRRSDDQCFFTESSRNQVVLTDLRRATQYEVQVRARTQAGYGSFSPAAIFRTLPDGHDSASQFLVPGILIAVGMLLLATFVFVAVYCIRRHSRMKDSELSDKSGQFLVGQGVKVYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVCRGRLKIPGKKENYVAIKTLKGGYTDKQRRDFLSEASIMGQFHHPNIIHLEGIITASCPVMILTEFMENGALDSFLRMNDSQFTPIQLVGMLRGIASGMKYLAEMSYVHRDLAARNILINSNLVCKVSDFGLSRFLQENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTHLHQLMLDCWQKDRSARPRFSDLVSALDKLIRNPASLKIVAQEGAGPSYPLLDQRAPLALSPCTSVGDWLRSIKMERYEDSFLQAGFNSVDQLAQLSTQDLLHMGVTLAGHQRKILSSVQTLTFQNKNTATVTF
The following text describes a protein:
Function:
May have a transcription role in testis.
Subcellular Localization:
Nucleus.
Sequence:
MKGKKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISDTSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDGPFSLCQPVGVGHNTDIQQIAANNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
The following text describes a protein:
Function:
May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.
Sequence:
MPNPKNSKGGRKNKRANSSGDEQENGAGALAAAGAAGAAAGGALAAAAGCGAAAAGAPGAGGAAGAGGAGTGAANAAAAAGAAAAGDAKNEAPCATPLICSFGRPVDLEKDDYQKVVCNNEHCPCSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTGRPPGEAAEEAKKCRPPNKPQKGPSHDLPRRHSMDRQNSQEKAVGAAAYGARSPGGSPGQSPPTGYSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAMAGGHVFRNAHFDYSPAGLAVHRGGHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHLQGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIGMQYFSEYSNVQQCPHCGNLDYHFVKPFSSFKVLEAY
The following text describes a protein:
Function:
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MHPHLVGESKLQHCAHLIQALNECHSKGVWHKITGGCNGIKHDLNMCLRQERVERTANHVKESRESRKRTEQIWKQIEQES
The following text describes a protein:
Function:
Acts as a receptor for cephalotocin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRYITTHPNEISTQIWNNFSSTEIWSNFSAAKNETQPIRRNQDLANAEVITLAVVIIITVIGNSIVLITLFQRRKKLTRMHLFILHLSVTDLFVAFFNNLPQMIWDITFLFLGTDLLCRLVTYLQSVAMYASSYVLVATAIDRYFAICHPLSSHKWTTARVHVMVFIAWMLSFLFSTPQLFIWSMQFSNIGLTCQATFDPEWTLKFYITWLTVAIWILPTIALTLFYGMMCFAVWKRGRSTLGSSRTRNRSFLTNRVSTRIGQSHLARGFSEEDMEGQSVNYNRGISRAKVRSVALTLSVVACCFICWSPFFVCQMWAAWDENAPYSGAIYTILLLLSSLNSCTNPWIYMIFSVFQHRAKTSRFVNDEETTSVTVLSSRNDIRLMSMKKKLEQTARN
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSQQNAVEALLARLQMGDTIPAFQSMGVDRIVSLRKMSEEALSQAVPDPEQRQALMDAIESRGHLQSRRAGPPAGQPHPPRSADADFARGGNDEGRGGYAPRGDRGGRIARGGRGGGRGAGAPNGDDAARVCRHVFTPEGCKYGDKCRYSHDENDRRRAQEVPTGSGMAQRSLERPPPNFKFSIEVEIPTERIKYLLGSQGNNMKFINETCGTYNERFDHVDEKEETFTIRILGGSEEAINKAKEMLLLSAGVKREEEKKDRFQYAVNELDANTHAARLFAACNTKNKDTTRHLSDSIMRNIVSSFHFVRPQEVRHFYMYTSSSDKDKLEMVSKIVSQLKGVQAILFCDQKRVEEMCKGSQRIARHFNGVEPQFVYRQLSKEDRMMALERFKKGVENENGVRQRLLVTNEDYAKLARKTIIPYVNLVINFSVPRAEEYYVLQSQVAGRQGTIGASFLCVSNYEEALFRELEKNIQFERFEDEEHFRTTAVELSYDTTAQPLTPEDADPPADWREHLNDKKPRQNFGKRR
The following text describes a protein:
Function:
Enzyme of the diterpenoid metabolism involved in the biosynthesis of the oryzalexin class of phytoalexins. Hydroxylates ent-sandaracopimaradien.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
METRELWVLAAALAVSLLYYLAALMRYAGGGCSRSSRPPLPPGPTPLPLIGNLLSLRGVLHHRLASLARVHGPVMALRLGLTTAVVVSSRDAAAEAFTKHDRRLAARVVPDSNRAHGFSDRSIIWLPSSDPRWKALRGIQATHLFSPRGLAAVRSVRESKVRDIVAYFRSRAGEEVVFGEAIYSGVLNLVSSSFFSVNMAGVGSEEAHGLRELVEDLVEAIAKPNVSDLFPFLRQLDLQGLRRRTEERMARAFGILDGIIDRRLANRTHGDRHGDFLDALLDLVSEGKMARDHVTIMLFEVFGAGSDTMSVSLEWAMAELLRNPRAMRKARAELEDAAAVVEESDAARLPYLQAVVKEAMRLHPVGPILLPHRAVEDGVEIGGYAVPRGAMVIFNAWAIMRDPAAWERPDEFVPERFMETTTAIDFRGKEYEYLPFGSGRRLCPGLPLAERVVPFVLASLLRAFEWRLPDGVSAEDLDVSERFNTANVLAVPLKVVPVIVN
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MLSVWNLPVEQQPQQQQQQQQNIINSSNNINSINSALDNILNTTSKGIQLPRFNLLNTSSSGFLTNSNDTLFLENNNNNNNNINQQLNKSVLNSSNKQLDIIKTINEISNEHKSFQPFEITPIKPQSTSTNTYNTEFGVINQNTFVLDSNKIEELRVDTSVLDPLLSLPYNIINNTTNNNNNNNNNNNNNNNNNNSNNNNSNNNNINNNNNKSNTPMKKESTIRNSNSTFEKFESPTLSTTFGLNKEELNTFTTTDMNNYVKQANMVKELSQVEKKELKRQKRLIKNRESAHLSRQRKRERLTDLEHRVEELSSNSIDINKTLSSLENENLILKAEVGQLFEVINDSPVLSALFYKIASLSQQPQKDTIGAY
The following text describes a protein:
Function:
Cell adhesion protein. Determines synapse formation. Required for correct localization of syg-1 at synaptic sites.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Synapse.
Domain:
The first five extracellular Ig-like domains are required for correct localization of syg-1; The cytoplasmic domain is necessary for syg-2 subcellular localization.
Sequence:
MLSQAILLWLFGSIHISSQFFLESPSNLSTIAGESITFRCSAEKSPEPIVYSQWKSNTGSLLGYHQEGILPGHQGRFSYIKQNAEELHLKITHVNLDDDGEYECQMLHPEEGPIRAKSFLNIIVPPQLVYFSNYQPNSIIAVKENTPLNITCVVPNVKPEPEVLWYMDGKVMSRDVKQASTPHLNKTFTVYTSLVVQSDRNDHGKVITCEAFQKETDIRITTNTTLDVLFPPSDPTVEILRNPSALRSGDNVTIACSVTGGNPPPDVFWYHENKRLQSHSTLDTRSKEIKNIYSFIASQNDNMAEYECRANNSRTGNPKRKAMKLEVNYPPASVELFGESNIRYGSSANIQCKSLPSNPASQITWIINGRSVPTPTQREFVVENGIVSSSNVSVHSNELSVEAHQINVECMATNPEGSSAKQHVIKIIAPPKAPIITGLEDRKFFEGDIVNVTCEAQGGNPLAELSWYRGSEKHLVKGRKKMKWSQVKKKLVMSLLCLCEVVIMNFFRFSKNVFYFFRFTLFIECGVNGAHNEVAGFSSYSTLALRVDRTMNTQRLKCEATNAALDEPLIESQYLSVYYPPRRVLIRPADSGDQRLLVGKSARLVCGTLSSNPAAHISWQFSRATDDNKVHLGDVSLNETTRDNGFNVENVLSFTPTEEYDGTVVHCIANHPEWKHSVNTSFPLNVMYPPKMLVNDPVTVVMSEGDSFKENLTVRGNPAISLWQWRKNGVPFDHTIGRVFARGAVLSGKQLLSTDAGVYTLTATNSVGSTNITIKLAVEYSARITSISTPVIAATGDTVLLECEADGEPSKANMIHWYKNGEILAAQHRGHKKAILRLNATEQQSGEYTCKADNGIGVPAEGQTFLLVNSAPRVLPVARYAKTAGILGGVAKARCKVYAVPTVEFVWEKDEQLIKKNSSKYSIVNTQIDYSTYESTLWIKNIVPDDYTKKVKCIARNSFGTDHLSIPIIPPTHPDEPFNLTMTNSTLNTISVAWEPRFDGGSDQIFEVKYRRQNDDLIHLVNTTHTNLRLSGLATANTYFFQIRSINARGFASSWTSPVIFATLNEDGVNVAMIRNEKLKLTTWIPYILIFIVLFMLLNVVICCFVCNRTKKRKLREKTEMARTAINGGDVRQVQMYGTMMGNDGMSRRDIDDRPEMSEDEHSVRTMIEVSPNGYMQPIEPMLYESTGLLEYDYQTRSYMGSSQGTRSMTYANVPYPEPPQPSYHSNWNSLQRQSNNNTSPQHHLSTFINPNMGVRAGPINYAQLDGDLV
The following text describes a protein:
Function:
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin (hag), which is implicated in polymerization, and participates in the assembly of the flagellum. An antagonist to translational regulator CsrA, it binds CsrA at an allosteric site and non-competitively inhibits CsrA binding to hag RNA. Partner switching by flagellin between FliW and CsrA provides a flagellar assembly checkpoint to tightly control the timing of flagellin synthesis. Flagellin binds to assembly factor FliW, freeing translation regulator CsrA to repress translation of the flagellin mRNA. When the flagellar hook is assembled flagellin is secreted, depleting intracellular flagellin, which frees FliW to interact with CsrA and inhibits CsrA binding to mRNA. This derepresses flagellin translation and provides protein for flagellar assembly. Once the flagellar filament is completed cytoplasmic flagellin levels rise and CsrA translation repression of flagellin reinitiates. Binds to CsrA and displaces it from hag mRNA. Binds to hag mRNA itself, but only at much higher concentrations than those required to displace CsrA.
Subcellular Localization:
Cytoplasm.
Sequence:
MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSPFVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPFEKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC
The following text describes a protein:
Function:
Mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala/Val (NPA).
Sequence:
MSSSDIFIGETIGTALLILLGGGVCAAVTLKASKARNAGWLAIAFGWGFAVMTAAYISGPLSGAHLNPAVTVGIAIKDGDWSNTPTYFAGQLLGAMIGAVLVWVAYYGQFQAHLTDREIVGGPGAQDTTAKSVEAQEKGAGPVLGVFSTGPEIRHTVQNLATEIIGTFVLLLAILTQGLNDEGNGLGILGALITGFVVVSIGLSLGGPTGYAINPVRDLGPRIVHALLPLPNKGGSDWSYAWIPVVGPLIGGAIAGGVYNVAFA
The following text describes a protein:
Function:
Transcription activator that acts as a flowering master switch in both long and short days, independently of the circadian clock. Promotes flowering upstream of HD1 by up-regulating FTL1, FTL4, FTL5, FTL6, EHD1, HD3A and RFT1. Seems to repress FTL11 expression. May recognize the consensus motif 5'-TTTGTCGTAAT-3' in target gene promoters.
Sequence:
MASNSSAAAVAAMFGIRDADHQDQMKPLLAQQHQQLLPPAPLLSAAASSSAVSGQATGASPPPVKKKRNLPADPDAEVIALSPKTLLATNRFVCEVCNKGFQREQNLQLHRRGHNLPWKLKQKDPAQAQRRRVYLCPEPTCAHHDPSRALGDLTGIKKHFCRKHGEKKWKCDKCSKRYAVQSDWKAHSKVCGTREYRCDCGTLFSRRDSFITHRAFCDALAQESARLPPPGLTASHLYGATSAANMGLSLSQVGSHLASTLGADAHSHHQDLLRLGGGSAASRLDHLLGPSNAASAFRPLPPPPSSAFLMGAPQEFAGDGDGTGSHGFLQGKPFHGLMHLPDLQGNGAGGPSASSAPGLFNLGYIANSANSSGTSSHGHASQGHLTSDQFSEGGGGGGGGGGGGGGGSESSAAMLFSGGGNFSGGDHQVAPGGMYNNDPAVMLPQMSATALLQKASQMGSSASAQGGVSVFGGLVGSSAPSAMHARPPMLDQSQMHLQSLMNSLAAGGMFGGANSGSMIDPRMYDMDQDVKFNQQGGRGGAEMTRDFLGVGGGGVMRGMTVPRGGHQTDGAAGDMSSLEAEMKSASSPFTGSRMQ
The following text describes a protein:
Function:
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular Localization:
Secreted.
Sequence:
MVSFSSLVLAASTVAGVLATPGSEQYVELAKRQLTSSQTGTNNGYYYSFWTDGGGQVTYTNGNGGQYQVDWNNCGNFVAGKGWNPASEKAVTYSGSWQTSGNGYLSVYGWTTSPLVEFYIVESYGSYDPSTGATHLGTVESDGATYNLYKTTRTNAPSIQGTATFDQYWSVRTSHRQSGTVTTKNHFDAWRNAGLQLGNFDYMIVATEGYQSSGSATITVS
The following text describes a protein:
Function:
Essential component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. May stabilize interactions between the major and a minor pilin subcomplex required for efficient pilus biogenesis.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MRTRQKGFTLLEMVVVVAVIGILLGIAIPSYQNYVIRSNRTEGQALLSDAAARQERYYSQNPGVGYTKDVAKLGMSSANSPNNLYNLTIATPTSTTYTLTATPINSQTRDKTCGKLTLNQLGERGAAGKTGNNSTVNDCWR
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MAPPMTNCLTFSLSPMEMLKSTDQSHFSSSYDDSSTPYLIDNFYAFKEEAEIEAAAASMADSTTLSTFFDHSQTQIPKLEDFLGDSFVRYSDNQTETQDSSSLTPFYDPRHRTVAEGVTGFFSDHHQPDFKTINSGPEIFDDSTTSNIGGTHLSSHVVESSTTAKLGFNGDCTTTGGVLSLGVNNTSDQPLSCNNGERGGNSNKKKTVSKKETSDDSKKKIVETLGQRTSIYRGVTRHRWTGRYEAHLWDNSCRREGQARKGRQVYLGGYDKEDRAARAYDLAALKYWGSTATTNFPVSSYSKELEEMNHMTKQEFIASLRRKSSGFSRGASIYRGVTRHHQQGRWQARIGRVAGNKDLYLGTFATEEEAAEAYDIAAIKFRGINAVTNFEMNRYDIEAVMNSSLPVGGAAAKRHKLKLALESPSSSSSDHNLQQQQLLPSSSPSDQNPNSIPCGIPFEPSVLYYHQNFFQHYPLVSDSTIQAPMNQAEFFLWPNQSY
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MCQVNGETFSPKLEPQIIHGKACVKCEKDSVIVVGTNGTFCKDCFEVYFSHKFRASMGRNPLVRHHDKVALAYSGGNNSSALLNLIKKGLDPATVKKLKFTPGLIFVDERILYPSDDYEKVKEIEEIMRNTGFPYHIVKLEEVGAMCIYTLYIGIVYLIVNHICFNVNVMFKKEIPFLNHVIFIIDQVFSTEDTDEKMTNAEKLEKLFNSITTLTSKQETLYRLRCYLLSRKAKELGYDHVFMGETSTRLAINILSNFSLGRGVHLPQDTGFSDGLRFEGVGVKLLRPMREMSMKEIAVYNALNKVPTVFLPNLATSQSVTSSVQNLTENFILGLVAGFPSTEMTVFRTSNKLHGKNDEKKSRGCCRLCFGAIDTECGTAQATALRHTLFSEAIN
The following text describes a protein:
Function:
The metallothioneins are involved in the cellular sequestration of toxic metal ions.
Miscellaneous:
MISCELLANEOUS: MT-I might bind approximately 11-12 mol eq of Cu(+).
Sequence:
MANDCKCPNGCSCPNCANGGCQCGDKCECKKQSCHGCGEQCKCGSHGSSCHGSCGCGDKCECK
The following text describes a protein:
Function:
Small heat shock protein required for the establishment of auxin gradients and for patterning of the apical domain of the embryo. Involved in the specification of the cotyledon primordia. Also required for normal inflorescence and floral meristem function, normal developmental patterning and thermotolerance. Acts as a molecular chaperone.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVISEYDEEEEQVQPRTSTSRQTKPSELVKPSKEIPAAAAPSQAQPRGQFPPPSQPDNIELHQHDPVLSAMLEEHKRHPLQLLTTVIDFLFRKTDLSRESRVESMVTEIVTAAIKRCAHEGEGVSPEKVAKVDQTKISIPEHDSHKSEPMDECRTPVNTSVGKTSAQHLQVKEPQGDEVAEGSEIAPSPPGKVEPVAAIDERPASKDVKVDEPIEDQGTGLKPNSGNGCDHEKYSWTQTLAEVTLHISLPQGTKGKSVVCDVKKTMFKAGLKGQSPILEGEFDNPVKPDDCYWTIEDDGTLCVTLTKCNRMEWWKSVVKGEPEINTKKVVPENSKLQDLDGETRQTVEKMMYDQRQRALGLPTSDESSKSEVLKKFMAQHPEMDFSKAKIC
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MERLKSLPLQPPTYGNLITILSIDGGGMKGLVPGTIMAFLGPLESELKLDGEDARLADYFDVIAGTSTGGLVTAMLTSPDENNRPLFAAKDIKDFHLNNCLKIFPQDSCPFAPATNMIKAVTGPKYDGKYLHKLIKEKLGNTRLNQTLTNVVIPTFDLIILKPSTGKVREFNLIDGGVAANNLTLVAMGEVTKEIIGGSSDFFPIKPVDYIRFLVISLGTGSAKVEGNNGESPLIDVFMQASADMVDFHLSVVFQALHIEANYLRIQDDTLSGAVASVDIATKKNLNDLVRTGVALLKKPVSRVNLETGRYEACNPESNEEALKRYRIVSSDVVKKFEGYMHSSGY
The following text describes a protein:
Function:
Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.
Subcellular Localization:
Nucleus.
Sequence:
MLGESVPAAVEQEQLGEVKLEEEEAVSPEDPRRPESRLRPEVAHQLFRCFQYQEDMGPRASLSRLRELCGHWLRPALHTKKQILELLVLEQFLSVLPPHLLGRLQGQPLRDGEEVVLLLEGIHREPSHAGPLDFSCNAGKSCPRADVTLEEKGCASQVPSHSPKKELPAEEPSVLGPSDEPPRPQPRAAQPAEPGQWRLPPSSKQPLSPGPQKTFQALQESSPQGPSPWPEESSRDQELAAVLECLTFEDVPENKAWPAHPLGFGSRTPDKEEFKQEEPKGAAWPTPILAESQADSPGVPGEPCAQSLGRGAAASGPGEDGSLLGSSEILEVKVAEGVPEPNPELQFICADCGVSFPQLSRLKAHQLRSHPAGRSFLCLCCGKSFGRSSILKLHMRTHTDERPHACHLCGHRFRQSSHLSKHLLTHSSEPAFLCAECGRGFQRRASLVQHLLAHAQDQKPPCAPESKAEAPPLTDVLCSHCGQSFQRRSSLKRHLRIHARDKDRRSSEGSGSRRRDSDRRPFVCSDCGKAFRRSEHLVAHRRVHTGERPFSCQACGRSFTQSSQLVSHQRVHTGEKPYACPQCGKRFVRRASLARHLLTHGGPRPHHCTQCGKSFGQTQDLARHQRSHTGEKPCRCSECGEGFSQSAHLARHQRIHTGEKPHACDTCGHRFRNSSNLARHRRSHTGERPYSCQTCGRSFRRNAHLRRHLATHAEPGQEQAEPPQECVECGKSFSRSCNLLRHLLVHTGARPYSCTQCGRSFSRNSHLLRHLRTHARETLY
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSNKPIIKNREFAEIQITAEQLIREARDNQTPSYTRPKMTIHDEEELQAYRLTKRKEFEQGVTKERQNPKRWTRYAFWEEEQGEYVRARSIFERALEQDYTIADTWMKYVDFELRNNQVNKARNILERATSLLPMVYKLWFKYVRLEETVENFDHCKEVFEKWMTFKPGEYPWLAYIKFEIRIGEIKVAKELFEQANQQLHCEEIYKEWVEFEKRFGTVESTRELFNKMAKDIEVCQNSYYQMFAEFELSQGEIERARQIYLFGIDHSKEENKRILLNNYVKFEKINGEMKDVDNAIWKKRRFEYEQKIQENPFDYDTWYDYIQMEMNEIESEETTTMLYERIISQTPQEITKEKWTRYIEFWVLYARYEEKLQHYENAFDIFSRTIKIIPHKYFTFKKVWRAYANYARRRKNIPLVRKIYGAAIGWCHKDDIFKDYIEFETENGEQERIHKIQAKWNEFKPKEIKQEEVNNE
The following text describes a protein:
Function:
Plays a key role in the control of the eukaryotic cell cycle.
Sequence:
MFSVFIVQTGWGINHRGQMEQYEKVEKIGEGTYGVVYKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHGNIVRLQDVVHSEKRLYLVFEYLDLDLKKHMDSCPEFSQDPRMIKSFLYQILRGISYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDIWSVGCIFAEMVTQRALFPGDSEIDELFKIFRVTGTPTEETWPGVTSLPDFKSTFPKWPPKELATIVPNLNPAGLDLLSKMLFLDPSKRITARHALEHEYFKDIGFVP
The following text describes a protein:
Function:
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.
Subcellular Localization:
Cytoplasm. Endosome.
Domain:
The JAMM motif is essential for the protease activity.
Sequence:
MNILQGSEAPLSYEEIASRAGAFDFNKNIPLKNWLRTSTTISKQAHVYVSEHDYSNGVFLLFRYCELFMKCQKHPDAAAYKKELFDYYQGVRNALEEIELIKPIVKEQYEQYQCQKNDLDDLKKLSMKDSQPSLEKPVSYVDEPILEQWALSDLQILPPSSTDLLSPDSQKLSKSSSDLPQFDYPSLNSSPTFNSNLPISSSRFEKTSLSDSKLVSPEPLDDNKDIQFIKKPIYTRTSEPRPKPAGTFKIHAYTEGGKPLRTIYLPKLLKKVFLDVVKPNTKKNLETCGILCGKLRQNAFFITHLVIPLQEATSDTCGTTDEASLFEFQDKHNLLTLGWIHTHPTQTCFMSSVDLHTHCSYQLMLPEAIAIVMAPSKNTSGIFRLLDPEGLQTIVKCRKPGLFHPHEGKVYTMVAQPGHVREINSKLQVVDLRVK
The following text describes a protein:
Function:
Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism. Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation. Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MADKAKPISPLKNLLAGGFGGMCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLVREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQIFAAGMLSGVFTTGIMTLGERIKCLLQVRIQASSGETKYTGALDCAKKLYQESGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNILTPEGKSVSELSVPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPNL
The following text describes a protein:
Function:
Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair.
Sequence:
MHHPFGKEEIASQKQLFGFFCECLRRGEWELAQACVPQLHEAQGDIPKKVEDILQALVVCPDQLRCGQDINPQRLAWVWFLVLEKWFSQEKKLLPSVFRRKLEFLLLSEDFQCDIPEDIFKELYEALAQDTRGPMLDGNQRRESWTPRLSSEAVSVLWDLLRQAPQPAQALLELLLQEDDGTGLYGWSLQKALVDLIRRALEAVQGPAAGPTGIVDAIYRALRSLHCPAEPLGVKLRLLCEELLEVCRAEGSPLQEEQVLSCLLHKAGQSLVSLYGHTYAEKATEKSVKAIPSGKVSPDHLDPEQAMLALFSNPDPTQAWKSAYFYCLSNSKHFLEQILVTALALLKEENFPSLGCLLDREFRPLSRLLVLLGWTHCQSLASARRLLQTLHRAQDQGCDKLLRDACDGLWAHLEVLEWCVQQSSDPIPKRDLLCHLHGGDSHSVLYSLHHLTNLPALREEDVLKLLQMVPAKDPQQDHDSAEALVPEHLSRCQNLTLYQSFCAMKYAIYALCVNSHQHSQCQECRDRASEDLAMAAEPANDSLSSPGASDLFSTYLARCQQYLFSIPDSLCLELLENIFSLLLITSADLHPEPHLPKDYAEDDDVEGRGFLVLRSPSESPQHIEQPERKSEQGCQGVPSSLPNIVPSCLKTDPKNSSPGPHGHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDKLTSHDPPEKPKLLEGQSCSGSRDGLQSRLHRFSKVLSEAQWRYKVATSNQGSEEQPSRRYRPVATGYLSLHRRHRTRKSWPDGQDRSSNPSLESTSSELSTSTSEGSLNAVSGRNELDGQLQPQSQSSLIPMMFSPPESLLASCILRGNFAEAHQVVFMFNLKSSPSAGELMFMERYQEVIQELSRVEHKIENQNSDGGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLSTSGEPIPTLQEDFWISNTPVEPTASLREVLEDLNPPAMAAFDLACCQCQLWKTCKQLLETAERRLNISLESRGRRLDHVLINADSIQGFPFVLQQISKILNYPLTSTGQTKLESVEEKGAGPPRCSIAELLQMCWPSLTEDCVSSHATLSQQLDQVLQSLKEALQLPEPRSTPLSSLVEQAAQKAPEAEAHPVLIQTRLLQKNLGKQTPAGSRQTDYMGTFFSYCSTVAAVLLRSLSSEPDHMEVKIGNPFVLLQQSSSQLVSHLLLERQVPPDRLAALLAREGLSLSVPKVIVNCCCEPLALCSSRQSQQTSSLLTHLGILVQLHTSHCLEDLPLSTLSSPKPTGDPTLKRKPRSSPRDSSHPALTSSALAFLKSRSKLLATVACLGASQGPKLTKPSLSWKELRGRREVPLSAEQVAQECERLLEQFPMLKASLLAAWEPLQQSTEQGQNLAVSLCGQASLSTVLLGLHSPSALDVLTEAFEEALVARDWPRALQLTEVYGRDVDDLSNIRDAVLSCATACDKEGWQFLFPVKDAYLRSRLTLQFVDKWPLEWCLEILAYCISDTTVQGELKCELQRKLAELRVYQKILGLQATPVWCDWQSLRNCCIEDPSTVMNMILEAKEYGLCEEWGCLYPIPREHLISLHQKHLLHLLERGDHEKALQLLQRIPDPTMCLEVTEQSLDQHPSLAASHFLATYLTTHFYGELTAVVLLTLPEPHRASYSHLSSNPLLMLEQLLMNMKVDWATVAVQTLHQLLAGQEIGFTMDDVDSLLSRYAGKALDFPYSLREKRSDSVTHLQEASQASDLETLSRSPSAEFSAAAAPGVSTVHSPSPRERSFPESQTPLEFVPPATPPGRHQWVPDESASICMVCCRERFTMFNRRHHCRRCGRLVCSACSTKKMVVEGCRESPTRVCDQCYSYYNKDVPEENPGQPEAPDSSKSESPPYSGVVRVPKAAEVEWILDLNEEENELVRSEFYYEQSPSASLCIAILNLHRDSIACGHQLIEHCCRLSQGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGRSQDLALCDSYISKVDVLNILVAASYRHVPPLDQILQPAAVTRLRNQLLEAEYYQLGVEISTKTGLDPTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLSHGSRLVQDVVEYLESTVRPLLSLQDDDYFATLKELEATLRTQSLSLEVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYMRHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKTYTELGEKLSWLLKAKDHLKIYLQDTSRGTRRKKTTFFQKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAATYCRAARQLVEREKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHSDDNKVQAYLTCCKLRSAYLIAVKQEHSRATVLVQQVQQAAKSSGDAVVQDICAQWLLTSHTRGTHGSGSRK
The following text describes a protein:
Function:
Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSDRKRKGNDAPNSLSNRDTVELPDDLSLSDSDSDEPLESFGRKIEDLSSSSEEEGETRQQVQSVLQENPSFRLTGGSSSFCDRSRDIFAQLDSAAKLTSKDLGEDNILDGTLARPAPPSPPHAVQNKCGVGQELTKKQPPGKKLPDYLAHPERWTHYSLEDIDETSDKKNSQVAHEYIRELQDSKRSQKAALETFTPAFNQDHGSSNENKIVFAKPKSKDQSGSRADHAKKEEVGLQHLDDRVEADEGEALQQSSSWPNKEKKRKWGVTKEEDDTVAPSAVFTSSKRVNRKNFRKTPDDNDGDKE
The following text describes a protein:
Function:
Participates in the breakdown of the egg envelope, which is derived from the egg extracellular matrix, at the time of hatching. Thus allowing the newly hatched fish to swim free. HCE binds tightly to the egg envelope while it exerts the choriolytic swelling action.
Miscellaneous:
MISCELLANEOUS: In medaka the hatching enzyme system is composed of two distinct proteases, the high choriolytic enzyme (HCE), of which there are two isoforms, and the low choriolytic enzyme (LCE).
Subcellular Localization:
Zymogen granule. Note=Stored as proenzymes in the zymogen granules.
Sequence:
MNLAPSTCLLLLFLLDIAQALPVWDEEGHEEGHEEGDGDDFVDITTRILTSNNNTDQLLLEGDLVAPTNRNAMKCWSSSCFWKKASNGLVVIPYVISSEYSGGEVATIEGAMRAFNGKTCIRFVRRTNEYDFISVVSKTGCYSELGRKGGQQELSINRGGCMYSGIIQHELNHALGFQHEQTRSDRDSYVRINWENIIPASAYNFNKHDTNNLNTPYDYSSIMHYGRDAFSIAYGRDSITPIPNPNVPIGQRNGMSRWDITRINVLYNCR