lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Two-pore potassium channel modulating the proton motive force (pmf) necessary to convert photochemical energy into physiological functions. Mediates the potassium efflux from the thylakoid lumen required for the regulation of the transmembrane electrical potential, the enhancement of the pH gradient for ATP synthesis, the regulation of electron flow, and pH-mediated photoprotective responses. Requires calcium for channel activity.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=PubMed:24009357 shows a thylakoid location instead of the tonoplast location previously described.
Domain:
Each of the two pore-forming region (also called P-domain or P-loop) is enclosed by two transmembrane segments (2P/4TM) and contains the GYGD signature motif which seems to be involved in potassium selectivity. The C-terminus is not required for transport to the vacuolar membrane.
Sequence:
MANEGSDPLLQYMISPRLKKPPQLLFPLPEDNEVAIPMPMTPSEFKERLIFGPFSCSPRDSSHFIDSMKQPSPSSSSTAVNNPFSDSSTLDPLLPPPPPQPEPWLSDQTSSHCQGHALHRSKTAPAMAVINDLHHPIRQKDPTETSRSVVRQAFALLVVYLSLGVLIYWLNRDHYVVNQTHPVVDGLYFCIVTMCTIGYGDITPNSVVTKLFSIMFVLVGFGFIDILLSGMVSYVLDLQESYMLDSAKRRDEPEKRRSYIIDVKKGRMRIRLKVALALGVVVLCIAVGVGIMHFIEEIGWLDSFYLSVMSVTTVGYGDRAFKTLPGRLFAAIWLLVSTLAVARAFLYLAEARVDKRNRERAKKVLCETMSVSQFFAADIDNNGCVSKAEYVIYKLKEMEKITDKDILPISKQFDKLDRCSNGKITLLDLLEGGSGD
The following text describes a protein:
Function:
Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (By similarity). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (By similarity). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (By similarity).
Subcellular Localization:
Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Sequence:
MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPRGLDTLVESIRREKTQSFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRCNSDESNLSEKQRASTVMYHPEGESSTAPFFSMASSLNLPVLEVGRTENSSFSSATLPRPGDPGAPPLPPDLRLEEGGSCGNSSEMFLPLRSRALSRQ
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MPTGICVLRPTATSRRGQEQFVHLPLSEPQLLENSDDSCKYGEKMAVNMLRLTVCRGTSFSRFQARAFLSTLSRQQAPLTSFVASQKLAPYQPQVSTVRLASADANYVNIWKAERLLAASLLAVIPGAFMFPNAVMDSLLAISVTMHLHWGVETIVVDYVRPSIFGAMIPKVAVGAVYALSISALVGLLYFNFTDVGIVKAVQLVWSL
The following text describes a protein:
Function:
May control important aspects of development.
Subcellular Localization:
Nucleus.
Sequence:
MGDQRGTRVYVGNLTDKVKKDDLEGEFTKYGKLNSVWIAFNPPGFAFVEFEHRDDAEKACDILNGSELLGSQLRVEISKGRPRQGRRGGPMDRGGRRGDFGRHSITSGGSGGGGFRQRGSSGSSSRHTERGYSSGRSGASSYNGREGGGSGFNRREVYGGGRDSSRYSSGSSASYGRTGGQSAGRFRSRSPVGNHRF
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAMVSVSHPVSFNSNVFSIRQEPLLASHASRIRYRLATRRWLNFSSASPPCRFNNLNSRCSITNSDSPCSHILTDDEIPQDVSGIEPDCSAPIIHIKSDILEVEPLSLLAEATFVDSLLTALPVLSEEEQNALAATPAHPVGLYAFYASCLAGNLVEQLWNFAWPSAIALIHPSLLPVAVMGFFTKLAIIVGGPLVGKLMDHSPRIPSFIGLNVIQVAAQLLSATMIIRAHTVSPTSASSILLRPWFLVLVSVGAIERLCGVALGVAMERDWVVLLAGINRPIALAQANAVLNRIDLLCEIAGASLFGILLSKYDPVTCLKFATGLMIWSLPIMIGLALLTNKLSTGVLDHTRFSQTCCRESNGTAVDDNSLVDRGLETIKLGWKEYMHQPVLPASLAYVLLCFNVVLAPGSLMTAFLTQRGVNPSIIGGFSGLCASMGVVATFLSATLVKRLGILKAGAAGLVFQASLLILAVAVYWSGSLSRQSPLLFFLGLIVLSRLGHMSYDVVGAQILQSGIPSSKANLIGATEISVASLAESLMLGVAIIANDISHFGFLAMLSLLSVVGAAWMFCRWLSNPTDEQRSLFSISLGYNF
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
KRWNKNKKKNWRNKIDLTDLEDNLDKQRLELRTGGLVKDKLDHELYVVEKKAGNVNELPKQKPKYKRLRVDQILVPNPKDIKPTSKRNCAKFKRREARQTLIAKLGKKKTPVRGRSKHVNLSLDIWNQESKEIAEKVFRKNEIMRHTEGVVGKAQIQRPLHLDNKFGVKQAVKAVEPAHPGASYNPTFEDHQDLMLQEHNRESHKIAVNEKIERAIATNPLEIATDESQQKEWMEGLFDGGEEESDLEEDDDEGIRVNPPVSTEDRKTRKVRKREAREKDELKKKKIEWENKLKEHEIFRTKTFLSEIKQKEKKMELRKAKRQLRDRMPVLSAVKYVEPDQDVQLSSDMRGSLRQLKPEGNLIFDRYKSLQKRCIIETREKFKPPRRKYKIKFQEKRSFREIEL
The following text describes a protein:
Function:
Transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MEADGGGVLPIPSQTASFPPHDDDDHPDFSPVGSPESHFINDHSEPSDQLHAQVTATVLTDDLRSKIVKQVEYYFSDENLPTDKFLLKYVTRDKEGFVPVKVIASFRKVKKLTKETSIIAAALRESSLLVVSRDGRKVKRLHPLPLSEIKDPKVCTVLVENLPEDHSVNNLRSIFGQAGNVKHITIRDPHTERDPRKCTTAEKLLSGKLHALVEYNTVEAAEKAVTILNDEQDWRFGLRVKLLKKINKPGQSKKGWRDPDSDRNNNIQASDPAVNEEHNSSEHRVDSQDEEEGDHLSKETIGEHAQKEKNGPRVPTRNRGRGRRNKRGTNGHGHGTTSSTHLVEPSKPPPGPRMPDGTRGFAMGRGRPLSSSPS
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MAFVAGAEVASERTTEMIPERTAEMAPEQNAAPGGAASVEEVHVVLDRSKFVKRVTVQALRVPKGACHQLVKKLSKFKAEYPKVRNVIVEEARPETRLILLGENVSGLDLAGLPESVAAELKADRDVEITQHEVVLDYDSYTADQVLKEVLPAGAEVPSSFETIGHVAHVNLRDELLPYRRIIGEVLLEKNFPRILTVLNKVGTIENEFRVPTFEVLAGDPSTVTEVKQHSARFQLDYAQVYWNSRLEFEHSRLVDQFAREDVICDMFAGIGPFAIPAALKGCAVYANDLNPQSTHYLAINSKLNKVAHRIRVSTLDAREFVRSLVRPAESQPPPLHPPSNSPPVDGQKFNSQASAAESSQAGQQISDQGLGLATYRQDNVGPASATETTTERAQGFPAGGTESRTSGEGPNGTLEAGTASRLSREVGSSSGPGGVLPSTGGAGQNASGGSGSVPPGGKVGKGGKAAAVRPPKEPVPETPRKIDHVVMNLPASGIEFLDVFNGLFDRASWRLPLPRIHCYCFARADETDADVIRRAEEALGGAIPKPVVWNVRDVAPNKTMLCVSFTLPDDVGYSQQDTMHMQCSSDKSSDVESHENPNFSKKSRVE
The following text describes a protein:
Function:
Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA.
Miscellaneous:
MISCELLANEOUS: In vitro, HdeA is more efficient than HdeB at pH 2 and HdeB is more efficient than HdeA at pH 3. In vivo, both are required for optimal protection against acid stress at either pH 3 or pH 2.
Subcellular Localization:
Periplasm.
Sequence:
MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM
The following text describes a protein:
Function:
Involved in localization of clathrin adapter protein complex-1 (AP-1) and subsequent AP-1-mediated clathrin-coated vesicle cargo loading. In complex with LAA2, cooperates with the small GTPase ARF1 and the phosphatidyl-inositol-4-phosphate (PI4P) synthesis to confer temporal specificity to AP-1 recruitment.
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalizes with AP-1 adapter complex, with clathrin-coated vesicles to the late-Golgi apparatus and with ribosomes. Localization depends on ADP-ribosylation factor (ARF).
Sequence:
MANRSLKKVIETSSNNGHDLLTWITTNLEKLICLKEVNDNEIQEVKEIHTQLDEFVRYISVLENTDDLELHSVFISLSQLYTISIWRLKDEYPGVVFDSAAFLTNVLCEEDVSIDDGDTDPNQKKKKKKSSTKKKKYIYSPAKDIACTILVQLFENFGSSISSLIPLLFNAIFKNLKKIMEKSKYYHATFMTTLLQLFNAILRNSNNDDKILDPATYAKFSKLSKTVFDSISTDEKDFSVTFVSVLIECWTAHFKQTNFIREHSHDIIETIYSRFTEGEIGVYGFANDETRIFTAKSLAEILFDYYFSKNILTLQEVWSIYVKIFLNCDTRDVESGCFESIIHLINLNLLADNTFLSNSKYLDIVLSLSGVFSSYEVNNRSMNTLSRYLRYFQHMHEVILPHLNDSAKTQMLYYILGCSDTYQSSSKSDSASNFKYSIDAKPETQWLTLLQLDFTYVLISDLGSTFTTEENTVKEIRDKLVDLATCEIFTIRVHTVEILKVFLNNCPEYLSETIENSLRALSTDFKSTGKFIFHKNHGHAFIIANLIKGAESDYISYELIMRITVFSTSFIKNNTTSTSSNLYFKGLLCWILLIGLMNYKDEQYLKLQIPQLFLFWKVLLTHTYTYHDEDELYKNLEIRNHALTCLLTYLSNTTIDKEMAKQVSYLLTKCSNFNHSIDLKSKNIDNALLHNENRILQVYLKLEKYINSDFNSSLLILIVKNFSDPNLYTESSSSVLGSLKDIGNRKVSNKDDMESNIVLESSINTLLRQNNGFAFGLSSKITGDRIVNLSMSSAYKYDESISGSWPSKDYNWYNIFEVEVSKPISPILSLDSLILLYGSGSYSQIDRYAPQVTTSLIDSSMELFSSVFPFLNSKIQYSIMETLNLSMFSKMTTPLRSVAVAANVCSALHNALRIMQENNLELDYSVGQLIIESIKKIQFFNDIFLTKIKADCVGLLTAAIARTLGDEERQKFLTEQSRIFIKNVADMDEPYLRMFHVLSLATIFKYNSQYANFEEYFDVIFALMRDPHPVVHSWSLKAMHILLEKHLVIDLKTAALLLSSMEELLVQDKYGIYGRSTLRCNYNRDFNSHVAIGEISRTLTETVGPNFLELNTKVLDSFRNITLSMLISNNILNSITSIKMFENIATFKMKNILNYEIFILASKSIIKSSIVTGIGSSYFDTTFTGSNELISRTSSLKGAFENFDLLTLLYKLQMEEFFMKEMENLSWRYLALFPNSGSVKNYFTEWILHTFKRDNHWFDKLYSIFNMSLGRLFQSYNRDVSALLEVNGLKKSSEKEIKGEEEESIANVNQLTDTDAGGLDSENLQWKSRQIILNLILMLCLESEKYENLLLALSNKIADLIKISFRGSTVRNEGMKLTGLHILNFVLKNYSTMRDPQVPGSSILEQQEAQITSALMPAFSKGSSPTVMSFAITVAAEVLASNIMPPDKLGRISQLLIDLLGNFKDPNSGIRIGEAIIVTPKAKRKIELAVLDAWAEVVQRSITSSNDALFSFTRKYWSILVPLWIISLREYMMIKYNDNDSTVQVKNDSKENSLIEPRSTKIELYEPVWLNFVEALGCTLDSDVQVILASLNDEELEYFLFILFSQCLEAIVKNIDDHSVKMQVLPALHNVLKSNLCIKSIFEDDIITEVVEIMDRLISTGDSKEEFLLVDIISDLIIGYSKCNATPETFLQDIDKLYELLRLLMTIISERLPFIKYNVLTSEEDDNEIKISPTDISLLKKTFIAFESNISNFDNMFKVDLYSCLLFIIGKIYECSHREVIIPIILPLFKALVKALTESEDEKNIVLLEIFYGSIKDVIYHKLDSKNKVATILILLSNGYSKLSFQELNQCANILSEALNNPATQPIALQGFKRIISNIFKYPLLQYFMKLVIKRFFQDIQTNDSLSQASIKTKLIIQFSEEVIKQDHQKASLSIALCLSFFAAYHSAYTEKIDNEVASGIVALAKLDKNSFKEAISSTISPQQKAIIGSVMEAYVKSQSLGSVEEAFQLKSFD
The following text describes a protein:
Function:
Plays a role in chemotaxis signal transduction system in order to colonize the host stomach. May act as a phosphate sink to control the flow of phosphate to CheAY.
Sequence:
MVRDIDKTTSLHLNNEAQFLCFRLDAEKDAQLYGMNIFKIREIIHYDGEVTEILGGSDGVMLGFLSVRGESIPLVDVKRWLHYNANDPSRDLKECSVKDDHNLVIVCHFSNHSIALKVLKIERIIHKNWTEISAGDKQGINEEGKLSAITRFDEERVVQILDVEKMISDVFPSLKDLDDLTLRCIEAIQSQKLILIAEDSLSALKTLEKIVQTLELRYLAFPNGRELLDYLYEKEHYQQVGVVITDLEMPNISGFEVLKTIKADHRTEHLPVIINSSMSSDSNRQLAQSLEADGFVVKSNILEIHEMLKKTLS
The following text describes a protein:
Function:
Required for the ingression of the plasma membrane into the bud neck at the end of cytokinesis, leading to the separation of the mother and daughter cells. Stimulates the synthesis of the primary septum (PS) by CHS2.
Subcellular Localization:
Bud neck. Note=Localizes at the contractile actinomyosin ring at the end of cytokinesis. Recruitment to the bud neck requires either CYK2 or CYK3.
Domain:
The C2 domain is essential for membrane ingression during cytokinesis, but not for recruitment to the actomyosin ring.
Sequence:
MSEEVWNGNQGILSVYVSKARDLPNLNKLDKQNVMLRLRIAHMTRASNTLHRAGQNPVFHYLEKFDITPEIKPLMYVEVYCDRRKKSPLPIGRCEIDLLNAIRADPKEGYCTWYELKRSGDEFAGTIFIELTFTPKVPRLNRDDLNKEMDRLDSSMAMRPIPPLPTESEYDYVHGSTMRQITPQCVSTSHEDKDEGQPYRNGNVFSMSSKSDTAVLANSNDPIILPPTFSASMGTTSTLETNDTAISNTSNTKFHFANLRKLKEKINIFKNPDSSTNNCQNESNKVDIEALQKAIGVTSLSYDEDDDDDDENDAFYSSSHRVSHNYNQPPLPPIPTRDDMSNYSSSRNTPLVRRDRPSRLDSSSPNSHPHPSGLNSPKLPPLPTTSNSNFNSRKNSMSPTRKRPPPRLS
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEQALFYILAAVTVIATVLAITEKHAVHAIVYLVTSFFALAVIFFTLGAPVVAVFEVIIYAGAIMVLFLFVIMMLDLGHPERARRPGIRDWWPALALGAVTLASALTLLISRAQAASAAGRAIGVKEFALTLFGKYGVAVEVISMQLLFALVGALYLAKRRER
The following text describes a protein:
Function:
Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
Sequence:
MVCDTDPARLTIAMLPIRSADLILGKCVHFNVFPKVFRRWISAGELNTLKTYAPKLRSEPISTKSLNGNAKLTRKTSARRFNFPRKNVISITPVAVDKLKELLLSQDKLLRIGVKQKGCAGQSYSFEYVDQPDKFDEIVEQDGVRVIVQRRALLQIIGSSMDFKDDDLQSRFVFSNPNVKSTCGCGESFVTNNP
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MDIERLVRTHVSTADLNPSQELVQGVNSGQVQLLQVVKALGNYLTSTEDDIRLKGLTFLTNLLGVIIPGKINRQATTTLTNFYISKLDDFESLPPALSGLTTLSKLTTFDDTAAVDVYKGVVENVNIKAYAQAIRHLVYVLFDSLLATHRDALKKMGTAFINSYTKIVDGEKDPRNLMLLFSIDRVILLEFDVKDHIEDFFDITFCYFPITFRPPPNDPYGITADDLKLALRECMASNPYFAKMALPLFLEKFATATGATMKDLMLTMAACFPTYGADAVNERSKELWEGIKTEILYSSDSTIEAAALSALESLMRALYPNEDSVPSGLAQEIIQECMKSLEEPEKNQALGSTKIIAAIFRGSPSAGKFALSQVFPQLFRTFNTPTVPSHRAPLLTAISSILLACQSTYNSSSRSHEQEQNLEPYRGDLLDILREGLRTDGLKGPAIKGCIALVGVQGYWSRKEVEDVVRGIDEILIHDENQEIRPEVIQALITISKSHPTVIESLTLPLLFHNLPSSAPSVEDFTARERYRSILGSLGRLCIQPALWGTMIVRVTSRLDVLVSATPENSEGADVEMDDIDARECNIAYAWDLLNSLLTVIEAKVKQKHMDVGKYYEELMPRLLGLVVRASQQKVGESGEPLFKDRRLVAIVSKIEEKMIWELGAEKQEKQFNLVYRAFEQGEMVGIVHEKSTVQSSSPLRTSASSAEQDLIALYSSALQGLSPPVSLPLASCGEYLRGKIHWTIHVARDDWQVKWGLQMVCALVNKKDNDLKEALEGVLEKIWAEVQDTTQDFEVRRRGLLVYFHIIKALSLLRQPLAYTALDKVIEVLGLFSMDPEFVSEAARAFGVLAKKGDGHLIAKLLYAQKLWNFVLPKLIEGDKEASGKERIVYLVAFASLLPLVPPSLCLSDLPTILPLIQRSLTLSSPVQRTNVIHALISILETPSSPSTDTILHSSASSLVSALLTSSVPSPETPTSSKVRQSALACLAIIPDTIRFEVLYKQKAEVIKELGNAVDDRIRNVRKEAVECRARWYRYGQAT
The following text describes a protein:
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
Sequence:
MSGGGIETPLGGEAAPTPAVVPVGGRKRDPQGPASSPVHLIIKDLGEIHSRLLDHRPIIQGETRFFVKEFEEKRGLREVRVLENLKNVIQETNEQILPKCRDTMHDHLSQALQKLQAATHLVHKLQQKEQEQRKLHNHHLLISEKQRITQWEDFMKEQHSKQSAVDEEHKKATERLKEQYAEMEKDLAKFSSF
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTPYLPRRLEQCSAHSKRLTNTNIVTITVPVKRKERGHQRRRGRPRAGRPSGTTFSPGRGEGRDLLFALRRATPARLPPSRGAGERKRGRASCPVAVGESLRRLSVRRARAEAPPRIAPPPPSPPQRPAAARPAASPFFKATPSAGRTGPGLPSLPPGRAAAVGRRRPGKMEGRRSLNGPEAAPTEAVESDDDGPEVTVGYDIHFTVTHVLSVTAGRSVDEAPEGPAGRLDGRSPGRPVGGAARRPSPDPGPATGILEMDYKGQELAEQIFMGIIQISAVIGFILGYWVEDFGWTISIFLSGLLISCMMTIPPWPMYRQHPLKWLPVQDSRLRSQR
The following text describes a protein:
Function:
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential).
Subcellular Localization:
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Sequence:
MISGLFIFNLKGDTLICKTFRHDLKKSVTEIFRVAILTNTDYRHPIVSIGSSTYIYTKHEDLYVVAITKGNPNVMIVLEFLESLIQDLTHYFGKLNENTVKDNVSFIFELLDEMIDYGIIQTTEPDALARSVSITAVKKKGNALSLKRSHSSQLAHTTSSEIPGSVPWRRAGIKYRKNSIYIDIVERMNLLISSTGNVLRSDVSGVVKMRAMLSGMPECQFGLNDKLDFKLKQSESKSKSNNSRNPSSVNGGFVILEDCQFHQCVRLPEFENEHRITFIPPDGEVELMSYRSHENINIPFRIVPIVEQLSKQKIIYRISIRADYPHKLSSSLNFRIPVPTNVVKANPRVNRGKAGYEPSENIINWKIPRFLGETELIFYAEVELSNTTNQQIWAKPPISLDFNILMFTSSGLHVQYLRVSEPSNSKYKSIKWVRYSTRAGTCEIRI
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MMVDIHINIVVNNNNSQSGDSHMSTMRRLNLTSPLRIVINGSSRMAISSPPQPPLHQPHNCDWSFDFYFPPLNIIASVLRLAWTAEVMRHVINLTVSEVLFVPAIEELIIITRGLILLEGEDEFMFACAHCCLGIMESTFRHGNDWAFVLIAAHGKGFGQASQDARQLFERQGMEPIVDSDITQLNLLPHRSMRWFYLRYCCGCLDCQRTSNLNCHSLAPVFFNWIPHGLSWHCPDNSFFSSVTVAIIDCLNKTIKDNQSRIKPSVPTTRVNS
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRWLPAFLSASLFAAGSFAARKSSEERFAEFHAKQTSHAPIKLKDSSFKSLTAPPRDYSVAVVLTALDPRYGCQLCREFQPEWELLSKSWVKGDKSGESRVIFGSLDFSEGRETFMGFGLQTAPVLFFFPPTIGPHAAASPEPIRYDFTNGPVPAEVVHSWLVRHLDGRPHPPVKRPVDYIKWAVSFTMITGSLTGVYVAWPYVVPVIQNRNVWAAFTLIAILLFTSGHMYNQIRKVPYVANNPRGGVSYFAAGFQNQYGLETQIIAALYGILSFAVISLAVKVPRIADPKSQTIAVWAWSGVLLVVYSFLLSIFRLKNAGYPFYLPPFM
The following text describes a protein:
Function:
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MRRSVIIGSLLATAAVGYAIYFDYKRRNDPHFRKTLKRRYKKVHEAKKQEEKLATKKFDITVEEALQVVASTPVPSSAEEKELFFMQQVARGEQLFQQQPDNIKESAACFYSALKVYPQPVELFAIYERTVPEPIMNLLRAMQAKESIPSVE
The following text describes a protein:
Function:
Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (By similarity). In the mosquito midgut, regulates the gliding motility of the ookinete which is essential for the ookinete to invade the midgut epithelium (By similarity). However, another study showed that while required for ookinete invasion of the midgut epithelium, is not required for ookinete gliding motility (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The EF-hand domain 1 cannot bind calcium due to the presence of a Lys instead of an Asp at position 435 and a Gln instead of a Glu at position 442 preventing calcium binding. The EF-hand domains 3 and 4 probably bind calcium constitutively when calcium levels are low, while the EF-hand domain 2 binds calcium following an increase in calcium levels; The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive. The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains.
Sequence:
MNDLIIKNNKKGSCDVIIKYKCKKSDENIKRRKSSHKYIKNKSVVLGRSIMTNKKEKLKGALKYKGSKKEIKICNKKSMIKNDKDENTTLKSMKSDNFKFSRRGFILSFTGNLEDFYNLSKEPLGKGTYGCVYKATDKLLKISRAVKVVSKKKLKNIPRFRQEIDIMKNLDHPNVVKLLETFEDSNQIYLVMELCTGGELFDKIVKKGCFVETFASFIMKQIFSVLNYLHIRNICHRDIKPENFLFYDMTPESLIKIIDFGLASYFTHNNYEMKTKAGTPYYVAPQVLTGSYNYKCDMWSSGVLFYILLCGYPPFFGESDHEILSMVKKGKYQFKGKEWNNISEEAKDLIKRCLTMDADKRICASEALQHPWFKKKKYAFNMDMKMDIHVLENFKNYGLLLKFQKLAMTIIAQQSNDYDVEKLKSTFLVLDEDGKGYITKEQLKKGLEKDGLKLPYNFDLLLDQIDSDGSGKIDYTEFIAAALDRKQLSKKLIYCAFRVFDVDNDGEITTAELAHILYNGNKKGNITQRDVNRVKRMIRDVDKNNDGKIDFHEFSEMMKLKF
The following text describes a protein:
Function:
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity). Required for the recruitment of P-body components such as cgh-1 in somatic blastomeres (By similarity). May play a role in recruiting the decapping enzyme dcap-1 to cytoplasmic puncta in the cell body of the posterior touch receptor neuron, PLM (By similarity).
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MDEVKKYGKTLEEIEGELMFGKISFMLFLFHCIFSDDFPESLADSDEEHNIFDDEFDAANDETFGGGLDNIGENAEQVNCLVRAYHSLFFQTARLRLDDPVWHHPSSSDQVAPDASAIPFPTFGNGDSSDTFKSSFEAESPFLKKSIWGNGADSSFNIWGSDFGIAAVPPSSSFDLDYNSIAPNEAQQVSPLVQQKPSSQIPSMPSSALTVTCLLYHEFLNLISFKLEDFERMQLGDSTDTLTAALNDLQLGSTNAQSKIEQAPTTLQSAPGEPLKAQTLPKLPVSALSLEELEQKIIRESQTVNVANTQQTPQGSNRFAHPPPGFTANMKNAQHPAMGPPMGMPGMQMPPPPMGYQQMGAIMQELPRLPPLNPQYLPLVPIWLGAIVNNMQLPMGVPPIPPFLYQLLNHYRNPSLVHAMIVHSSIPPNSRPNGPQFSGPQVGPHSPGARGQQRRNSGMPSTRTIYDLALDSFAGYMSFKEREWLIRIQFVQCKGSGDPCIDDYYYVRWRESQIANGWTAHPKPESKQPLPASSESRKDYLERIRRMNYREMQKERLRDREKERQRERQERIDRGEERKPRQTLTDKFATSLGLPSKSSTHNPRHVLDMKAQVDSVDNQAKKLSDEERKNAVQKKLRTMLLRLEGALVLLMEAEELRRTSSSDKSQFKDLTSEEKEQEVEKRTSLIIDEFMGDDLPKLMQMSKGRAVLTRTLKVVGPRDQARIILSLMIAAGLVSKKMYGEIVLDILPVVHQKVSNLHPDQFKYLVGALNLDNIKRQLMDSNMFVRDVMLTLYLVSVKNNQNLLEWSKQTKFSSLKMPSSAPLGFWRKALSAVTDAEITEFAEDIKYSGVVDCHEVAKLIEQSL
The following text describes a protein:
Function:
Mediates sugar transport across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MEAISEALQPYKEQVGMAAGILTVGQMFSGCFVCNDIRKKGTTDGFSAMPFVGGCGLTVLFLQHGMLMNDSAMTNANLVGLTISLAYAIFFLLYTPPTGRSSYWRQVGGTALFTITLLGYVKVENPSVVEDRFGMIITVLMLALIGQPLFGLPDIIRRKSTEGLPFAMILSGTIVGLSWLLYGVILNNVFVVCQNLAAVTLSGIQLALFAIYPSKAAPPSKKRE
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
Sequence:
MMKSNASPSESLSHHTPMMQQYLRLKAENPDILLFYRMGDFYELFYDDAKRASELLDISLTKRGASAGEPIPMAGVPFHAVEGYLAKLVQMGESVAICEQIGDPATSKGPVERKVVRIVTPGTVTDEALLSERVDNLIAAIYHHNGRFGYATMDITSGRFQLSEPQTEEEMAAELQRTSPRELLFPEDFSPVHLMASRQGNRRRPIWEFELDTAKQQLNQQFGTRDLVGFGVEQAKLGLCAAGCLIQYVKDTQRTALPHIRSLTWDRQDQSVILDAATRRNLELTHNLAGGTDNTLAEVLDHCATPMGSRMLKRWIHQPMRDNATLNQRLDAITELKETALYGELHPVLKQIGDIERILARLALRSARPRDLARLRHAMQQLPELHSVMSELKQPHLTELRTHAEPMDELCDLLERAIKENPPVVIRDGGVIADGYSAELDEWRDLANGATEFLERLEAEERDRHGIDTLKVGYNNVHGFYIQVSRGQSHLVPPHYVRRQTLKNAERYIIEELKQHEDKVLNSKSRALALEKQLWEELFDLLMPHLEQLQQLAASVAQLDVLQNLAERAENLEYCRPTLVQEAGIHIQGGRHPVVERVMNEPFIANPIELNPQRRMLIITGPNMGGKSTYMRQTALIALMAHIGSYVPAESASIGPLDRIFTRIGASDDLASGRSTFMVEMTETANILHNATRNSLVLMDEIGRGTSTYDGLSLAWASAEWLAKEIGAMTLFATHYFELTELPNVLPHLANVHLDAVEHGDGIAFMHAVQEGAASKSYGLAVAGLAGVPKPVIKNARAKLQQLELLSSQPAETRKPSRVDIANQLSLIPEPSAVEQALAGVDPDQLTPRQALDMLYQLKKLL