lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity).
Subcellular Localization:
Nucleus. Nucleus, PML body. Nucleus, nuclear body. Cytoplasm. Note=Accumulates in the cytoplasm upon FAS activation.
Domain:
The HSR domain is important for the nuclear body targeting as well as for the dimerization; Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Sequence:
MEDSNASPRMSTEHENTEMHPFEYMFKHFKTQKVAISNAIRSTFPFLESLRDREFITGKMYEDLIDSCRSLVPVDKVIYKALDELEKKFDVTVLWELFNEVNMEKYPDLNPIRRSFECVFPNELSFQGIDRGNPNSQLSLEQGPSASYSQGSLNGSSLDLSSSEGWRSNDRRNSNLMQANQTENHQLAESPGHLDSCELQVQLNNGDATPESYSLLPQHEERAVQLNNEFQINPCFVQLIDVKKENSSFSLAGNQQTRARTNQNEDSEVIELSSGDSDDGENFSEATTTIPSQPAPAYSRTPPTLRTDRRGDTSDTESSIIIRRRKRTGRKKRERLGSYLIRNIKIPMKTSWKTAVLARSANTSSQRRRKRGPRIPREENADFGGAELPAVCGNVQGFLNKEKFKQGIYVRSIRSETGRLFTPMDFEIEGNCEKAKNWRQTIRCKGWTLRELIQKGVLQDPPRKKKENPRNPRQMKRQVNAL
The following text describes a protein:
Function:
Component of the large subunit of mitochondrial ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MSFWKVATLWQMPLRPSILVQVRTATKRAAGSRTSMKDSAGRRLGPKKTEGQRVEVGQIIMRQRGTRFYPGENVGIGKDHTLFALEPGWVRYYLDPFHTGRKFVGVALYQDMRLPIEHFAPRVRRFGRQLLSGKEAETEEQALPRSVFLAKEKILERAQQRADAREQRRAEFGHILREELGLALDQDAEQLATEYLLRVQTNLKSGFNSADARFNAMYHMEVRMRNTPEKVGQMDLLKKTVASVDAATSFSNKFELGRHISEGERVAWREALHKDLAGLVIRTAEEKQRVVERLKEASKYLSLSEEIHLRRKFLKPVKPETEAVAEAAGKGTVTIKRFNYGTGKVDTIIREKKAFLAKL
The following text describes a protein:
Function:
Probable transcription factor. Controls central cell differentiation during female gametophyte development.
Miscellaneous:
MISCELLANEOUS: Plants lacking AGL61 show a reduced size of the central cell and a reduced or absent central cell vacuole. When fertilized, the central cell fails to give rise to endosperm and the embryo sac degenerates. However, mutated female gametophytesol are not defective in pollen tube guidance and the synergid function is not impaired; MISCELLANEOUS: This protein was called 'DIANA' after the virginal Roman goddess of the hunt.
Subcellular Localization:
Nucleus. Note=The transport to the nucleus is dependent on dimerization with AGL80.
Sequence:
MYVTKYKNKLPTLQVDLIIMPHQTQACIYKQTLSLHQIFQQRKATKTLHTKKTMMSKKKESIGRQKIPMVKIKKESHRQVTFSKRRAGLFKKASELCTLCGAEIGIIVFSPAKKPFSFGHPSVESVLDRYVSRNNMSLAQSQQLQGSPAASCELNMQLTHILSEVEEEKKKGQAMEEMRKESVRRSMINWWEKPVEEMNMVQLQEMKYALEELRKTVVTNMASFNEAKDDVFGFLDNKVTVPPYVNMPSGPSNIYNFANGNGCF
The following text describes a protein:
Function:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity).
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus.
Sequence:
MSSAPPGPAAPRLCCMEKGPDGYGFHLHGEKGKPGQYIRLVEAGSPAERSGLRAGDRLLEVDGTNVERESHQQVVERIRAAAGAVRLLVVQPQPEEQPPKTHSDPDGEAQREPPAAETPAAERSGPEERELRPRLCRIKKGPNGYGFNLHSEKSRPGQYVRAVDPDSPAEAAGLRAQDRIVEVNGTSVEGKQHADVVAAIKAGGDETKLLVVGVLADEFFKKCRVVPSEAHLAGPLPEPMANGDVEKENGGEPRLNSVSERPPSPALATSPEGSETHSEPDTQEGDKRSSAPSSLLDLDIPLAVAKERAHQKRTSKRAPQMDWSKKNELFSNL
The following text describes a protein:
Function:
Involved in maceration and soft-rotting of plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MLSLLIVLALAVATVAAPPPPVSRAGRPSAPPGCLAVGSSSQYKTVQSAVNALSTTSTTAQCIFIAKGTYKEQVYVQALKSPLTIYGETTDTSSFSANTVTITQGKSQDDTPTNDETATLRAHTANLKVYNINLVNTRGSGSQALALSAYSGKQGYYGCQFKGFQDTILAQEGTQVYAKSYIEGATDFIFGQKGQAWFHAVDIRVLTASVGYITANGRESATNPSYYVINKSTISAASGNNVKAGTYFLGRPWRNFSRVVFQNTSMTNVINSAGWTIWNTGDPRTDNVEYGEFGNTGDGSKGTRASFSKKLSKAVAIETVLGSDYKSWVDTAYVS
The following text describes a protein:
Function:
GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (By similarity). Also converts Cdc42 to an inactive GDP-bound state (By similarity). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases (By similarity). Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Endosome membrane. Note=Association to cell membrane is dependent on PH domain.
Domain:
The BAR domain is important to associate RAB8A (or RAB8B) and RAB10 to endosomal membrane to promote tubule extension. The BAR domain is also important to recruit WDR44 to endosomal tubules.
Sequence:
MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKTLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETERNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPPPFGSSWVKHYCMYRKAAKKFTMIPFEHRSGGKLGDGEVFFLKECIRRHTDSIDRRFCFDVEAADRPGISLTMQAFSEEERKQWLEVLGGKEALFPSFNRAIIPRPEGSAQLDKMGFTILRKCIRAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSVDWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTPPDATLPEPGPLSAPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDRPSLPKEDTPPSSLDSLSSPSPTTATALGHPGPDRNHLLTDGGSFGDWAPTAPSQARSSAVQWLNPQSPTTPSCSPAVTPPSPKLPPVPLSLPATVADKPPESIISRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL
The following text describes a protein:
Function:
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS).
Sequence:
MDNTTTTTTTTSTPTNTAGNGKFLKIDLHTHILPKNWPDLKEKYGYGGWVSLDHHCSCKAKMIIDGKFFREIDSNCWDPEVRIQELNRDDVDIQVLSTVPVMFSYWAKPQDALDLSQYLNDHIAQVVSENPKRFIGLGTLPLQDTEASIQELRRCILELGLAGVQIGSNINGKNLDDESLFPVFEECEKLGAAVFIHPWEMVGKERMPAYWLPWLVGMPAETCLAMCSMIFGGVFERLPKLKVCFAHGGGSFPFTIGRIEHGFNARPDLCAVKNPINPRSYIGKFWVDSLVHDEEALKFLVKLMGESKVIMGTDYPFPLGEQIPGQLIESIKEFDEPTKQRLLGDNALEFLGLTRDKFM
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (By similarity).
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Melanosome membrane. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MAGEGLGQQGASATAAPETREHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAGQERFGNMTRVYYKEALGAFVVFDISRSSTFDAVLKWKNDLDSKVHLPNGSPIPAVLLANKCDQKKDNSQSPSQMDQFCKDHGFTGWFETSAKDNINIDEATRFLVENMLANQQSFPSEEIDLDRIKLVEEPPTTKPRSQCC
The following text describes a protein:
Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Sequence:
MTESTATKESEGAPASSAPVTNAIDPASDAAPATTTTATTTTATGGAKSEPVVDDRPPLLPLSSAATTDVVTDQSRAKDKENDEKNRRVREGDDRDRQTREIRAGLHPLQHRFVFWYTRRQPGIRSQTSYEDNIKKIADFSTVEGFWGIYCHLARASTLPNPTDLHLFKEGIRPLWEDAANRSGGKWIIRFKKLVSGRYWEDLVLAMIGDQLDFGDSVCGAVLSIRFGEDILSIWNRNASDNQAVMALRDSIKRHLHLPIGYMMEYKPHDASLRDNSSFRNTWLRG
The following text describes a protein:
Function:
Constituent of pre-60S ribosomal particles. Required for large subunit rRNA maturation (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKSQRSQIKNEDISFVSQEDDSSKKFVKDDSENSEEELEDLNSEDEFYQSNSSEDEIEEEVQESTIADDIADILNQQVTQTDEQDTPVLSLSKKSKKALRKSNAEKKDSKLRTSRRRERLRKEMVGRVTSVVAVNAETAKALFTHERELRRIARRGVVQLFNAVRTAQLQSSLNRENISGGRTAREQKVKELSKASFLDLIKSQ
The following text describes a protein:
Function:
Required for telomere maintenance.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MLENENQLTHQFPTLSRWNPMFISDVHKISFHPHLQRYIGFWMGFPIRWIQIVGYIAAIDIYEGKHVLTVDDCSGMVLRVVFIIQDDFSMSKRAISMSPGNVVCVFGKINSFRSEVELIAQSFEELRDPNDEWKAWQKRMRYKKNLTKISKNHHSIIRTPKKSYFPKDHAKELLKCIRQMCKLNVQAGFTIEELIIYLKAKELHLPLVHIFNVENEIVENCDGNHILALNFSLQTLLQHGRIVRKSNSVYMLVTSKDIIRFVIPLMASGLLEAHKVQSIVRDSNPMFITLPLSAIAKHICQFLLRTKGKWRQAKKYTWVRDNQFV
The following text describes a protein:
Function:
Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters. Plays a significant role in the specification and morphogenesis of the sensory retina. May play a role in specification of V2a interneurons during spinal cord development. Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 and MNX1. Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1. Acts as a negative transcriptional regulator of MITF. Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (By similarity). Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor. Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells. Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation. May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGHLLAARSVLSPAGVGSMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEVERQALPKLDKMEQEERAPEAQAAISQEELRENSIAALRAKAQEHSTKVLGTVSGPDSLARNAEKPEEEDATEEDRPAEKLSPPQLEDMA
The following text describes a protein:
Function:
Functions in tapetum development during early meiosis. May play a role in the endoplasmic reticulum (ER) membrane in the early stages of tapetum development in anthers. Seems to function after MSP1 and before UDT1.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGRDEMLRRSLVALAAAVVVTGVVTASVRKAAATYGFGILAIAGVLLPDWEFFDRDYSQWLTPMPASRRTAAEAAADREHDVWKFKPYPLRMAMLTTIYGFGLYKWWMYVSS
The following text describes a protein:
Function:
Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors.
Sequence:
MKKVVTVCPYCASGCKINLVVDNGKIVRAEAAQGKTNQGTLCLKGYYGWDFINDTQILTPRLKTPMIRRQRGGKLEPVSWDEALNYVAERLSAIKEKYGPDAIQTTGSSRGTGNETNYVMQKFARAVIGTNNVDCCARVUHGPSVAGLHQSVGNGAMSNAINEIDNTDLVFVFGYNPADSHPIVANHVINAKRNGAKIIVCDPRKIETARIADMHIALKNGSNIALLNAMGHVIIEENLYDKAFVASRTEGFEEYRKIVEGYTPESVEDITGVSASEIRQAARMYAQAKSAAILWGMGVTQFYQGVETVRSLTSLAMLTGNLGKPHAGVNPVRGQNNVQGACDMGALPDTYPGYQYVKDPANREKFAKAWGVESLPAHTGYRISELPHRAAHGEVRAAYIMGEDPLQTDAELSAVRKAFEDLELVIVQDIFMTKTASAADVILPSTSWGEHEGVFTAADRGFQRFFKAVEPKWDLKTDWQIISEIATRMGYPMHYNNTQEIWDELRHLCPDFYGATYEKMGELGFIQWPCRDTSDADQGTSYLFKEKFDTPNGLAQFFTCDWVAPIDKLTDEYPMVLSTVREVGHYSCRSMTGNCAALAALADEPGYAQINTEDAKRLGIEDEALVWVHSRKGKIITRAQVSDRPNKGAIYMTYQWWIGACNELVTENLSPITKTPEYKYCAVRVEPIADQRAAEQYVIDEYNKLKTRLREAALA
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Sequence:
MHLLSFLSFIIWFIHCTAKRHEYSIKKYFLNSHNFCKIKPDPFRKDTLKKRLYSSDGIKDEIIIGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLYGGKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSINDMNTVKSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNINTRIEKLYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLCHVNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGNCMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKEIIGTEQFNKIKAEAELHLLNNK
The following text describes a protein:
Function:
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
Subcellular Localization:
Cytoplasm.
Sequence:
MVVKQKADYAALKEELIAYAYEIGIQKIGFTTADPFLFLKERLLEAEALDLFTGFEHPVIEERVYPELIFKEPQSIIAIALAYPSKLKEAPVSKKGARRGVFARASWGIDYHTVLREKLALLETFLIERLPDVRMKSMVDTGELSDVAVAERAGIGWRGKNTLLITPEYGSWVYLGEMITNIPFEPDTPASDLCGSCNQCVKACPTGSLLGEGKMNPKICLSYLTQTKDFLDEKYREVLHNRLYGCDTCQVVCPYNRGHDFHFHEEMEPDPELVRPELKPLLHISNRAFKEQFGDMAGSWRGKKPIQRNAIIILARYKDKTAVPDLIDCLQNDPRPVIRGTAGWALRKIGGRDAEEAVERALQTEQDVQVLQELTAIPN
The following text describes a protein:
Function:
Transcription activator. Binds the promoter core sequence 5'-GGNCC-3'.
Subcellular Localization:
Nucleus.
Sequence:
MEEVVVGGKERKRPRGALVGVGGGGASAATAAAWRTSRVARAAAGGKDRHSKVVTSRGLRDRRVRLSVPTAIAFYDIQDRLGVDQPSKAIEWLIRAAAAAIDALPSLDCSFALPAAASSPPPPAADDAEVSTSETSKSSVLSLANAPCDNGGGAFAELLHCSNTNGSKPLQQQQQATLAYYAAAQSAHMAAPMSFEVMAMPPHLAFSQEQQQHATVAAFDRGTLQSNASLWPPPPQPPPSQHPFLLQRFAAAPAEVAGLPFFLAGGVGGAAAAAPAATTNGGERRLQLWDFKEERKT
The following text describes a protein:
Function:
Transcription cofactor. Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding. May play a role in DNA-damage response signaling. Binds specifically to DNA sequences at peri-centromeric chromatin loci.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MPLPEPSEQEGESLRAGQEPSRGARKPQESSSLVPARDKEKPKPTDVMSQETSSTTTLPNNTLQALPAKKQGRIIHRKRSRVDAVAPQPLEFLKTPSGSRLLVHKSFLYKQEKAVGDKVYWKCRQHSELGCRGRAITRGFRVTEMRDHCHPPEKEGLGKKRRQKEKLPSSGTEGQGDGVSLWLYPVEPEPTPQPSIETPEEEQGYRSLALQSLPPKKRPTPGVVRYRPLEFLKTCYGGTFLVHQSFLYKREKTVGSKVYWTCREHAVHGCRSRAITQGQRVTVMRSHCHSPDMEGLQARRQQEKTIKKIQARRIGAGDLEDCDDIEDTLLQGVDSLFYRRGPGTLTLSRSRSRKRAKKQQEPLQESPEEEDQDVDPKGPEFLKTPLGGNFLVYESFLYRREKVAGEKVYWTCRDQARMGCRSRAITQGRQVTVMRGHCHPPDLLGLETLRQRQKRPGPAQWDGPEGPEFLKTPLGGSFLVYESFLYRREKATGDKVYWTCRDQARMGCRSRAITQGQRVMVMRRHCHPPDMGGLEALRQRENFPNLTHWEGPEPVQPLEFLQTSLGGRFLVYESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQGRRVMVMRSHCHSPDLAGLEALRQREREKAREREKAREREKAPSAAKKKKKKKKKKGKSKS
The following text describes a protein:
Function:
Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 521 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MAEQTLLSKLNALSQKVIPPASPSQASILTEEVIRNWPERSKTLCSDFTALESNDEKEDWLRTLFIELFDFINKNDENSPLKLSDVASFTNELVNHERQVSQASIVGKMFIAVSSTVPNINDLTTISLCKLIPSLHEELFKFSWISSKLLNKEQTTLLRHLLKKSKYELKKYNLLVENSVGYGQLVALLILAYYDPDNFSKVSAYLKEIYHIMGKYSLDSIRTLDVILNVSSQFITEGYKFFIALLRKSDSWPSSHVANNSNYSSLNEGGNMIAANIISFNLSQYNEEVDKENYERYMDMCCILLKNGFVNFYSIWDNVKPEMEFLQEYIQNLETELEEESTKGVENPLAMAAALSTENETDEDNALVVNDDVNMKDKISEETNADIESKGKQKTQQDILLFGKIKLLERLLIHGCVIPVIHVLKQYPKVLYVSESLSRYLGRVFEYLLNPLYTSMTSSGESKDMATALMITRIDNGILAHKPRLIHKYKTHEPFESLELNSSYVFYYSEWNSNLTPFASVNDLFENSHIYLSIIGPYLGRIPTLLSKISRIGVADIQKNHGSESLHVTIDKWIDYVRKFIFPATSLLQNNPIATSEVYELMKFFPFEKRYFIYNEMMTKLSQDILPLKVSFNKAEREAKSILKALSIDTIAKESRRFAKLISTNPLASLVPAVKQIENYDKVSELVVYTTKYFNDFAYDVLQFVLLLRLTYNRPAVQFDGVNQAMWVQRLSIFIAGLAKNCPNMDISNIITYILKTLHNGNIIAVSILKELIITVGGIRDLNEVNMKQLLMLNSGSPLKQYARHLIYDFRDDNSVISSRLTSFFTDQSAISEIILLLYTLNLKANTQNSHYKILSTRCDEMNTLLWSFIELIKHCLKGKAFEENVLPFVELNNRFHLSTPWTFHIWRDYLDNQLNSNENFSIDELIEGAEFSDVDLTKISKDLFTTFWRLSLYDIHFDKSLYDERKNALSGENTGHMSNRKKHLIQNQIKDILVTGISHQRAFKKTSEFISEKSNVWNKDCGEDQIKIFLQNCVVPRVLFSPSDALFSSFFIFMAFRTENLMSILNTCITSNILKTLLFCCTSSEAGNLGLFFTDVLKKLEKMRLNGDFNDQASRKLYEWHSVITEQVIDLLSEKNYMSIRNGIEFMKHVTSVFPVVKAHIQLVYTTLEENLINEEREDIKLPSSALIGHLKARLKDALELDEFCTLTEEEAEQKRIREMELEEIKNYETACQNEQKQVALRKQLELNKSQRLQNDPPKSVASGSAGLNSKDRYTYSRNEPVIPTKPSSSQWSYSKVTRHVDDINHYLATNHLQKAISLVENDDETRNLRKLSKQNMPIFDFRNSTLEIFERYFRTLIQNPQNPDFAEKIDSLKRYIKNISREPYPDTTSSYSEAAAPEYTKRSSRYSGNAGGKDGYGSSNYRGPSNDRSAPKNIKPISSYAHKRSELPTRPSKSKTYNDRSRALRPTGPDRGDGFDQRDNRLREEYKKNSSQRSQLRFPEKPFQEGKDSSKANPYQASSYKRDSPSENEEKPNKRFKKDETIRNKFQTQDYRNTRDSGAAHRANENQRYNGNRKSNTQALPQGPKGGNYVSRYQR
The following text describes a protein:
Function:
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSAQVMHNRVMGTVKDSASKLVDFLMRHHGQTVLLTGAGVSTDSGIPDYRGPQGIYSRNKDFKPIQYQQFVGPHEFRQRYWARSFLGWPKVSQAQPNASHHAIAALESRSHIAGCITQNVDGLHRRAVVIENPNLLEIHGTLHWVNCISCGYKLQRSAMQEQLQKINPIVYEWQRLNPEKSNADVASSLNPDGDVEIKWDYNHFKYPHCPECNGLLKPNVVFFGENMPMTVRDTSFKMIDDAKALLVVGSSLQVYSALRLVKRAASTGKPIAILNLGFTRGDELAQIRINLGSSAVLEELASTIR
The following text describes a protein:
Function:
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
Subcellular Localization:
Cytoplasm. Note=Localizes at mid-cell.
Sequence:
MSAQPVDIQIFGRSLRVNCPPDQRDALNQAADDLNQRLQDLKERTRVTNTEQLVFIAALNISYELAQEKAKTRDYAASMEQRIRMLQQTIEQALLEQGRITEKTNQNFE
The following text describes a protein:
Function:
Endoplasmic reticulum (ER) translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (By similarity). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (By similarity). Works in concert with the ER Ca(2+) pump srcA to support ER homeostasis. With srcA, also supports redox homeostasis and virulence.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
Contains a large substrate-binding pocket that recognizes alpha-helical transmembranes, which alternately faces the endoplasmic reticulum lumen and cytosol, while remaining accessible to the lipid bilayer through a lateral opening (By similarity). The translocase alternates between two conformations: inward-open (E1) and outward-open (E2) states (By similarity). Undergoes a series of conformational changes with ATP-binding, phosphorylation of the Asp active site and subsequent dephosphorylation in a Post-Albers cycle (i.e., E1 -> E1-ATP -> E1P-ADP -> E1P -> E2P -> E2-Pi -> E1) (By similarity). A substrate transmembrane helix with a short, preferentially positively charged lumenal segment binds to the outward-open pocket and the E2P-to-E1 transition flips the transmembrane by a switch from the outward-open to inward-open conformation (By similarity).
Sequence:
MLRAKLVDDPQIKYASLHNPLPTQLHAYVWPFLIIWPAFFAVYLSPERYDTYIQGQEWTFVWSGSIITAQSLLWLMTKWNINIQTLFTATKARSLDSAQLIKVIPVANAGSAEICPLHCDTMGGKKTFSFLFQKRRFLYYPERQCFAPLSYVLDAEPKPPVKVFQQAQGLTSKEEIDRIQHHYGDNTFDIPVPTFMELFKEHAVAPFFVFQVFCVGLWMLDEYWYYSLFTLFMLVVFESTVVWQRQRTLNEFRGMNIKPYDVWVYRQKKWQELTSDKLLPGDLMSVNRTKEDSGVACDILLIEGSAIVNEAMLSGESTPLLKESIQLRPGDDLIDPDGLDKNAFVHGGTKVLQITHHNSNGEDGSEKARKLSSGVPLPPDNGAVGVVVKTGFETSQGSLVRTMIYSTERVSANNVEALLFILFLLIFAIAAAWYVWQEGVAKDRKRSKLLLDCVLIVTSVVPPELPMELSLAVNTSLAALSKFAIFCTEPFRIPFAGRVDVACFDKTGTLTGEDLVVDGIAGLTLGHEGADVGKDGAHTELAKSANVPLDTTLVLASAHALVKLDEGEVVGDPMEKATLQWLGWTLGRNDTLMSKAAALAGPRTVESVQIKRRFQFSSALKRQSTIATVVTADRKTSKKTKATFVGVKGAPETIRTMLVNTPPHYEETFKYFTRNGARVLALAYKYLSEESELSQGRINGYIREEIEADLIFAGFLVLQCPLKEDAIKAVRMLNESSHRVVMITGDNPLTAVHVARKVEIVDRDVLILDAPEDDMSGTRLVWRSIDDKFNRDVDPTQDLDPEIIETKDICITGYALAKFKGQKAFSTLLRHTWVYARVSPKQKEDILVGLKDAGYTTLMCGDGTNDVGALKQAHVGVALLNGSPEDLAKIAEHYRTTKMKEIYEKQVSMMQRFNQPPPPVPVQIAHLYPPGPRNPHYQKAMEREAQRKGAATLATAGNQTEHIPTITSPGAQALQQSNANLTPQQQRQQQASIAAAGFADKLTSSMLEQELDDSEPPTIKLGDASVAAPFTSKLANVIAIPNILRQGRCTLVATIQMYKILALNCLISAYSLSVIYLDGIKFGDGQVTISGMLMSVCFLSISRAKSVEGLSKERPQPNIFNVYIIGSVLGQFAIHIATLIYLSNYVYSIEPRKSDIDLEGEFEPSLLNSAIYLLQLIQQISTFSINYQGRPFRESIRENKAMYWGLVAASGVAFSCATEFIPELNEKMRLVPFSTEFKVTLTVLMIIDYAGCWIIENVLKNLFSDFRPKDIAVRRPDQLQREMERKKQEELETQAEKERQRKV