lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein.
Sequence:
MSSRRPRRIKKTPFLTKVKSFPFDLFLSINESLAVLELDNLPQTYHIYLGLAADITMILIRLYFVRFETKKKRDAALFHSIGNNKARGGSGYYSLSAQAAAKRRSSNAIYSILMMTALALFAISVINMLVCFLQTKKYTLFGRDVSNVPGTPSAALEPLETPCDDLNQSGEAQFKTMIKKRLSGFMSPAPAPPVVDPTTTDRPTRVWVLNVWEPSLFHLNIFALFSPIHVIALWFGPLSFVQVFITLPAFSFALYAMSHMFLVYVKDKNIISGEVLGEFDKKVVHPLLGVIKQDAAVGADGSCEFYDAALDNKSVYREAGMAPSKPPTPVKLDTPTRRRTFVPTSGQLPGAGAQAGDGLRHFSHRLMDDRRGSSGYTPSSFGNTGPSVPNHTTLSGSPVGRPWRRKQ
The following text describes a protein:
Function:
Required for ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MPFKPLVTAGIESLLNTFLYRSPALKTARSRLLGKVLRVEVKGFSTSLILVFSERQVDVLGEWAGDADCTVIAYASVLPKLRDRQQLTALIRSGELEVQGDIQVVQNFVALADLAEFDPAELLAPYTGDIAAEGISKAMRGGAKFLHHGIKRQQRYVAEAITEEWRMAPGPLEVAWFAEETAAVERAVDALTKRLEKLEAK
The following text describes a protein:
Function:
Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.
Subcellular Localization:
Mitochondrion.
Sequence:
MRILTKARAFNPHLAEMFSNKIPYYYSRAHMADPEACQKILDKLDLKSKYDGSKLDIVDVNPGYGLFSTMLNYELKPRNHILIENKERCVTSLSSIINKLVEETGHNSNFTLYKKDSFIWETYNDLIDKDKLIQPQIKSFDTPHDELLILANWTGNKEESVLAQWIKCCGHRNWLMKYGKVRMVIFAPSVSAMKFLGEPGFKKRRRTGLKRDLYTDSRLIGVVNSEKAPGLGYDARVLVRDQPVLLEPSSAHRDEDYSVIEISPGKYTASQIENIEHFLSAIYLTNKKLVDILPTLAPGAMYMAKDLPEEMLQKSSYEFTCEDIIKLSEAYENWPFKPSVADLYDFDITFS
The following text describes a protein:
Function:
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
Subcellular Localization:
Lipid droplet. Cytoplasm. Mitochondrion. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm.
Sequence:
MDQRGEDTTLAPHSRMSGDQTAQDPGSSLGELDQQNVVNRVVALPLVKATCTAVSSAYNSAKDRHPLLGSACRLAEHCVCSVTTCALDHAQPLLEHLQPQLATVNDLACRGLDKLEEKLPFLQQPSDMVVTSAKDTVAKSVTGMVDLAQRGRRWSGELRRSMSQAMDMVLGKSEKLVDRFLPMTEAELAVLAAEAEGPEVGTVEEQRQQQGYFVRLGSLSARLRHLAYEHSLGKLRQSKHRTQEMLAQLQETLELIQHMQRGASPSPTFHPPKTQELWGSWSPCLENGRSHSEVELETLALSRSLTLELQNAVDALAGCVRGLPPSAQAKVAEVQRSVDALQATFADAHCLGDVAPTALAEGRGSVARAHACVDEFLDLVLRAMPLPWLVGPFAPILVEQSEPLINLATCVDEVVGDPDPRWAHMDWPAQKRAWEAESADPGGQEAEPPRGQGKHTMMPELDF
The following text describes a protein:
Function:
Involved in autophagic vesicle formation.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MNSQQYQQEIWNMRLAVKVSLLNSNIPPLYLMIYRQHYLLFYYQQIYDHFNSYSPQINKINQITFQYKNTILTYQIPFGVLIDQYKSEDTFTPIELILIYQKQAQFFTLEDEIKNQIKFNLKWACFGRYNHEGYGDPIKNLTQNVSINDEIQAFKRIKSFEGKEDLFQYYMKIFEKPNTGKIQLPIRIYFKKGGHFQTIIEITDQQQTIGQALNTKIQGINFIFNGLPLNTKISAQDFYDYLYSIDGFCYFVC
The following text describes a protein:
Function:
Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.
Subcellular Localization:
Nucleus.
Sequence:
MPQPGSSVDFSNLLNPQNNTAIPAEVSNATASATMASGASLLPPMVKGARPAAEEARQDLPRPYKCPLCERAFHRLEHQTRHIRTHTGEKPHACQFPGCSKRFSRSDELTRHSRIHNNPNSRRGNKAQHLAAAAAAAAANQDGSAMANNAGSMMPPPSKPITRSAPVSQVGSPDISPPHSFSNYANHMRSNLSPYSRTSERASSGMDINLLATAASQVERDESFGFRSGQRSHHMYGPRHGSRGLPSLSAYAISHSMSRSHSHEDEDSYASHRVKRSRPNSPNSTAPSSPTFSHDSLSPTPDHTPLATPAHSPRLKPLSPSELHLPSIRHLSLHHTPALAPMEPQAEGPNYYNPNQPHVGPSISDIMSRPEGAQRKLPIPQVPKVAVQDMLNPSGFTSVSSSTANSVAGGDLAERF
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MYRTAAKRLLAGGGITTTRLLRLPKLRSTIIPSSYTSGLCTSSIGGNTESPMGKQSVNPNQSGPTASSSTGTGEGQRRHESRKPRAEFQEEQARVLSASLRHVPRLGWTEEAMMAGSRDVGVSPSIVGSFSRKEAALVEFFMDECLQLLMDRIDSGLDLQNLIPSERISKLIRIRLEMQVPYMSKWPQALSIQAHPLNVPTSFKQRAMLVDEIWHAVGDGASDLDWYVKRTILGGVYSTTEIYMLTDDSLEHRDTWAFLDDRVKDAFDLKKSIQEAKYFAEDIGAGVGKSVQGLMNGVMQTMSRRSGGSAF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
LSQRDSDVAVDFTQEEWCLLDHSQKELYLEVMLENVEHLISCFQQGKAPWLLEKKGPRSFSPDFKVKLICTKLSPFMEGSVPQRCMNEGPCDVILRESCDSTIKVNKNAKSDYEIDKIAEKFSHYSILTQYMKLTSGNDCCQDSKYRKCFPEEVGFVQSPQQPKMPVYQGNVGGMSFGWSLDSIRHPKGKTFKMVSTYTWRSTLTKHQSIHTGEKHYECQHCGKAFRHRCSLIAHQSIHNGEKPYECKQCGKGFTQKGYLAFTYKSSLVQHERIHTGEKPYECKYCRKAFKYESSLFKHERIHTGEKPYDYQHCGKAFIQRDKLITHQSIHTVEKPCECLHCGKIFRQRNCFVQHERIHTGEKPYECKHCGKLFRQKGHLITYQSIHTGEKPYQCQHCGKAFIEKRSLAKHQSIYTGRKSYECKHCGKAFYTQEQTCYTSENPHWRETL
The following text describes a protein:
Function:
Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity). Essential for male fertility and spermatogenesis (By similarity). Required for meiosis prophase I progression in male but not in female germ cells (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.
Sequence:
MMTTLQNKEECGKGPKRIFAPPAQKSYSLLPCSPNSPKEETPGISSPETEARISLPKASLKKKEEKATMKNVPSREQEKKRKAQINKQAEKKEKEKSSLTNAEFEEIVQIVLQKSLQECLGMGSGLDFAETSCAQPVVSTQSDKEPGITASATDTDNANGEEVPHTQEISVSWEGEAAPEIRTSKLGQPDPAPSKKKSNRLTLSKRKKEAHEKVEKTQGGHEHRQEDRLKKTVQDHSQIRDQQKGEISGFGQCLVWVQCSFPNCGKWRRLCGNIDPSVLPDNWSCDQNTDVQYNRCDIPEETWTGLESDVAYASYIPGSIIWAKQYGYPWWPGMIESDPDLGEYFLFTSHLDSLPSKYHVTFFGETVSRAWIPVNMLKNFQELSLELSVMKKRRNDCSQKLGVALMMAQEAEQISIQERVNLFGFWSRFNGSNSNGERKDLQLSGLNSPGSCLEKKEKEEELEKEEGEKTDPILPIRKRVKIQTQKTKPRGLGGDAGTADGRGRTLQRKIMKRSLGRKSTAPPAPRMGRKEGQGNSDSDQPGPKKKFKAPQSKALAASFSEGKEVRTVPKNLGLSACKGACPSSAKEEPRHREPLTQEAGSVPLEDEASSDLDLEQLMEDVGRELGQSGELQHSNSDGEDFPVALFGK
The following text describes a protein:
Function:
Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptors (GRIA1, GRIA2, GRIA3 and GRIA4). Binds to a different site than does the drug cyclothiazide. The toxin acts like a straitjacket on the 'gating ring' of the ligand-binding domain (LBD) of the receptor. It does so by restraining the domains via both intra- and interdimer cross-links such that agonist-induced closure of the LBD 'clamshells' is transduced into an irislike expansion of the gating ring. Compared to other desensitization blockers, it is a poor stabilizer of the open channel because toxin-bound AMPA receptors undergo frequent brief closures. In vitro, application of the toxin to hippocampal slices causes a large and rapid increase in resting AMPA receptor-mediated current leading to neuronal death.
Miscellaneous:
MISCELLANEOUS: Ikot-ikot is a Filipino word that translates to 'spinning around' or 'turning around', a reference to the swimming phenotype observed in fish injected with the toxin.
Subcellular Localization:
Secreted.
Domain:
The cysteine framework is CC-CC-C-C-C-CC-C-C-C-C.
Sequence:
MAMNMSMTLCMFVMVVVAATVIDSTQLQEPDLSRMRRSGPADCCRMKECCTDRVNECLQRYSGREDKFVSFCYQEATVTCGSFNEIVGCCYGYQMCMIRVVKPNSLSGAHEACKTVSCGNPCA
The following text describes a protein:
Function:
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Sequence:
MFGKLREKLKKFTKQVEEKIEEEEKAVEAPMAGEEIQKAVQESTETEGEKPGFLGRLLQVEIKEKDIEDALDELEIELLEADVALETVEALREKIKEKLVGRKVRIGTNKGKIIEEALKEAILEILTPEKKIDLLQMIKSKEDKPFVIAFVGFNGSGKTTTIAKLAHWLKKNGFSVVIAASDTFRAGAIEQLEEHAKRVGVKVIKHDYGADPAAVAYDAIQHAKARGIDVVLIDTAGRNELNRNLMDEMKKIARVTKPDLVIFVGDSLGGNAVVEQAKQFNEAVRIDGVILTKLDADARGGAALSISHAIGAPILFVGVGQGYEDLRPFDEKWFVERIFGED
The following text describes a protein:
Function:
Involved in mitochondrial biogenesis and G2/M phase cell cycle progression.
Subcellular Localization:
Mitochondrion.
Sequence:
MLLKQLPQAVQQIRCISSATTAVTRLHRSVYCRLYPTVVVQPDGSTINIRYHEPRKIIKLPLDLSTLTDAERRARLEARKPRKKVKIMEEVEDNFNAKKYMKYIKKK
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular Localization:
Nucleus.
Sequence:
MSMDHMMKAGEQPFVSEPVNFSNFAYFAKASAEECRLFASEERAIENFQKTTHLSDTTANEILSLIDVSDLCPLVFNREMDGGLERNPLVSQAIILDENSKRRNAQFKSIALRALRYDHIEHSALARKSAHHLLPEDDVKEEYEDFEEADDDIQMYEPDPEIIVIPQASTSSMEIDSSEKDLIISVSIYLGYTRELQYHEIRLGRLLKVTDRLELTGQHTLLDLKNAFSCPADFAFHEDFSEKKPAIQDFAKNKWPSSMFFIHDTFYVEPGFEDPSLTIRNWAQSRSYIGPMNVESMVDKKLGELVCRLGQPYVYIHQGVCEHLVVFNDLFLRDESHENVVFPRRLVERNFRRIACDICKARQLKHENLLPSSPGYLCSSCYKEFCFDVHGKKVSQFKAVPYCDRKDIGDGGKFISELRFEAAQEK
The following text describes a protein:
Function:
Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MAPAASRLRVESELGSLPKRALAQYLLLLKLYPVLTKAVSSGILSALGNLLAQTIEKKQRKDSRLLEVSGLLRYLVYGLFVTGPLSHYLYLFMEYSVPPEVPWASVKRLLLDRLFFAPTFLLLFFFVMNLLEGKNVSVFVAKMRSGFWPALQMNWRMWTPLQFININYVPLQFRVLFANMAALFWYAYLASLGK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDSSLLSAATADTFNGNAADQIPPPLQPPGTDMTGISFRDQLWINSYPLDRNYIFDYFALSPFYDTTCNNEILRRRSIHPLDLSHLSKMTGLEYMLTDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGSIYQAPQLCSVFAARVSRTIYNISKAFTDAASKLETIRQDLQVCLVAIVLSLSVNLGSYFLLIFKLMANGEQVYGFNKFLFDTENQNEPAESKPASETVDLKEMKRVDVILTSLYRKLAPPPPPPPFPEGYVSQEALGEKEELGTQGGESQPPQVDPIIDQGPAKRMKF
The following text describes a protein:
Function:
Actin-associated protein that may play a role in modulating actin-based shape.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MGTDDQVLITLSGEGPWGFRLQGGSEKNLPLIVSKVRKRSKACRGGLRENDELVSINGKACAGLTHAQAMLMIDSIGGSLHIHVRRAAAGAQTAPRTQRVLPSPSSPNRIRSPDPPSSWAATQSTVLTSAQPRLLHLESITSPPDSEAYYGETDSDADIQASSAHPPSNQQHHSLQPSAPEKHRRARKKSPRSPPGSSNKTESEQKSLSEMSGYESGPGGVAECALQPTIGVAKREIIYQPGGSRAETPFSDVEGFLPSDDVEQLPSVTSPSPESLLLPHVTKSIRAERHLIPMIGPVEHPVDDDLTTTYSDKAREAKLHRSESVQEKNVKEARTKCRTIASLLTDAPNPHSKGVLMFKKRRQRAKKYTLVSYGSVDEDRYIEDEDGVFPTSESEFDEEGFSDARSLTNHSDWDSTYLDIEKPKMDEQQVEKGLTEASGKGAELFELQRQRSEQSPVDSVPLPIPVPLQQRKENQTAPVAPVRKKMLNGNANSSAIVNKTQEMGVSESPKVASTNISITPPQSQPTQVDGVQASSEIFNRSARPFTPGQTGQRLVASSVVFKPSSPKKTSEIPPSQIITPSPIPSFIPETPLNAEKVPICSVASLYIPAPGRADMPSTTNQVQCERVPENLSNQTTPRTTTASIYLSTPSRPSGPQASVTHANVTKLTDCTPMTPTSNVIGLPSTGQVDASPYFTPKISANQSLDSVNTREQRISVPVGRSGILNEARKRGGKKQMFAKVEEKKCLPSPELLSMVQRTDGKSKQEQTGAGFESGPEEDFLSLGAEACNFMQPSARKFKLPPPVAPKPQRRTPVDEILNGGQDIPHLGGKGAELFAKRQSRMDKFVVDSTPTSSSRPNSRPRTPSPTPSLPSSWKYSSNIRAPPPIAYNPLCSPFYPLAASKTQASKVASKVKKGPSGKPRMQAIDFMRHQPYQLNSAMFVFDDSSNSPNQTPTKRDTQKSNVLASPARQVPVKTARAHEIKRFSTPVPMTASISMTPTVITPRSATTLAEPVWRTDLTCQPMPSVVTVPNQCQVPEQKTPQNFIPSSYQSYGILSPTSSITSPRSSSSTFQVAKPKFCAAKTGMQANVWRPAKVKF
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MKDNDRCAKFMANDLGKVLSYDEMICNRIQENDKKLKDLVYSNYSKFIQVTETITKIRHSAESFDNDLTSISKSLSELTSRYKNIHANLSPLREELISLHEKQQQIEQQQEFLDLPDILRQTASESKWIEFANAYTSKIDGLKKNAHIKAFASILAEVEGAVARAEKALNNAISKEYDTPQKLGQCYGALARLHTNEAVMEINCIAKMQKYCEVVVDNSFTKKESNVASFSSFISTAATAFVNAVQSCCEAYNTAFKEPFSLDSKSFDNFVGISISNFYSKANDIVSQASSLDKPELKVVEALRGISDATGKIKNLNQYGDYNKYIENTIENAARFGIKELCKKVGLKAGSVFDTISVDIDLCVSRGFVGFNGLAEKKQNQIDDIQKELKDRIDAIKQIGGVYETTIINSLKEYGSDILTIFLQKAESVCENKPFVCVAIAGWILSAKIPEIIAIALRIDSLAQQYTDQYNQFPEKLIKKFTDLISEQMHSSFIELFAMNHPPLSPSLLVRSGSLKVSSLMIGASNILKVYFPDNTNPFDDNTPKRDSSKTFYFDSDESKDDLIELERTSIIEAIVVKTMKQLRNDIPLYTAPPPDGLTLKEFQQYHVDLMVFSNTINEIVKIKSSKIENYIKQINLRLESCCSEGAITATNEVSLIKEAMLKINN
The following text describes a protein:
Function:
Does not seem to have nitrate reductase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRHLHTALWGVLPYLTLVVLVAGTAWRYRYDRFGFTTRSSQLHESRLLRIAGPLFHYGLLFVIAGHVAGLLVPESLTDRLHVSEHLYHANALIAGGTAGLATLAGLALLLYRRLRTPAIRAATSRSDRVVYPLLLTVVLAGLTATASGATAASTYDYRLGVSVWFRSLFALDPDVTAMAQAPLVYRLHALLAMALFALWPYTRLIHAFTAPLGYLVRPYVVYRYRGRGEVGAGRPGR
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MACHANNLNTRGAVASLSHTELKCTPLSILLPLPSHSPTRTHSIRSSSTLSPRTMRRLSRAAALPLLLLLALAAATTTTTVAAAAAAKAKAPAAAAPPAPPNVTAEMAKGGCKAFADLIAASPDASSTYQSAVEGGLTVFCPSDDAVRAFLPKYKNLSADGKAELLLFHAVPVHYSLGSLKSNNGPMNTLATDGAARNFNFTVQNQGDVVTIRTAAGSGAPARVKSTAVDKDPLAVYVINAVVEPVELFKPAPSPTPAPAPAPAAAADAPKAGKKGAARHAPPAVADAPGPNADDNAAPVDQKDANKKSAAAGAPCDRWWLATVLAAAVASALA
The following text describes a protein:
Function:
Involved in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34 to form mnm(5)s(2)U34.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAAGFFQAEMSILSSTLARSYSLPIRKTLMTFDFRIAMQRNPCLRIRRSCVAAFSSTPSHSRNFPIRGLEDVFVGYLFGRKKATEVAHVVWEQVIQKGDTVIDATCGNGNDTLAMLKMVMHDSVGCGGYVYAMDIQKDAIESTSSLLDQAVGSKEKECVKLFNLCHSKMGEIVPENARVRMVAFNLGYLPGGNKSIITLSDTTLSALKAAERILKPGGLISLVVYIGHPGGREELEVVEAFGSGLPVSDWICCKFQMLNRPLAPVLVFMFKREN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MYPWVVFLPPGLQGRNPSPFPGSGRGCPRERTVCPPEPRSPCQLEMDAEQKAAATAPQENDELPATTPEEDVGGSDCERESILQEGGPAPGCSQQPVGRPCSQEAAVPREALSRLRELCRRWLRPEMHTREQLLTVLPAEIQTWIREHRPESSDEVVTLVEEDSVLPAPQESTENQEMTTSLFMARSQDEWRRLDPGSKTCYRDVTLGFTVPKPGMISWLEGGEEPWISGSQSSSEEEIPGEVHKGFEMSENEEEHTKPDISEEMESRGTPMGRSSRAVVQNSFWSKASESKRGAESQPLVPVGESPGKSTPEENDRRKFPVHPETFTGEQLYICSQCGKSFTQSSHLMKHQLSHSGEKYYNCADCGKSFSNSSNFIRHQRTHTGEKPYKCPDCGRSFSQSSALITHQRTHTGEKPYQCGECGKSFSRSSNLTTHRRTHMGEKPYKCCECSKSFSQSSSLIAHQGVHTGEKPYECRECGESFSYSSNFLRHQRTHTGERPHGCPQCGRRFSRSSQLAMHQRTHTGEKPYRCLQCGKSFSRGSFLAMHQRAHTGERPYKCSVCGKGFSWSSVLIIHQRTHTGERPYKCPACGKGFSNSSNLITHQKTHTREKAY
The following text describes a protein:
Function:
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MNFKDLRDFLDYLEQRGELKRITHPIDPHYEMTEISDRTLRAKGPALLFENPLGYDFPVLTNLFGTPERVAMGMGRQQVQELRDVGQWLAYLKEPEPPRGLKELIEKLPVFKQVLNMPVKRLRRAPCQEIVWQGDAVDLDKIPVMSCWPDDVAPLLTWGLTITRGPHKKRQNLGIYRQQKIARNKVIMRWLAHRGGALDLRDWMEKHPGEPFPVSVAFGADPATILGAVTPVPDTLSEYAFAGLLRGSRTEVVKSISNDLEVPASAEIVLEGYIDPNEFADEGPYGDHTGYYNEVERHHVFTVTHVTMRNKPIYHSTYTGRPPDEPAVLGVALNEVFVPILQKQFPEIADFYLPPEGCSYRMAIVTLKKQYPGHAKRVMLGVWSFLRQFMYTKFVIVCDEQVNARDWPQVIAAMVNHMSPLRDTLFIEHTPIDSLDFASPVVGLGSKIGLDATAKWPAELAVSNSDQSDKTTELSLEALKACLSDEADVLDVALPEAANDKLVLLLINKQEAGQAQQLLQRVVDKLNGDSPLKFVILCDDDVNIHDWNDVIWAMTTRMDPARDSLRIVGQDLICFDATNKLPDEVEREWGTPIRKDPKLVAKIDSLWDELGIV
The following text describes a protein:
Function:
Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVLDKLRAKFHIRKELVRAALAEFTGTFLLCLIGLSVVAQKVLPRPEVNEFIGVNVGFGIAIVFGVAVSAKLSGGHINPAVSLAFLTVGQITVVQFIAYFFAQFLGAFFGAAVVYAVYNDAINVFDGGVRTVGGVKDTAGIFASYPAPHLGLLNGFVDQFVATAVFVFLIAHIVDKRNSYPTWLQPILVGTGFVAIGAAFGYNCGYPVNPARDLAPRLFTAIFYGGAVFTKWFWVPIVGPFVGAVVGIWFYYFLIGFHTPQDAEEKYVVLTGNQELKPLTSKDATEETA
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKLFNARLIVFIGALLLGVGFSVPSLLETKGPKITLGLDLRGGLNMLLGVQTDEALKNKYLSLASALEYNAKKQNILLKDIKSNLEGISFELLDEDEAKKLDALLLELQGHSQFEIKKEAGFYSVNLTPLEQEELRKNTILQVIGIIRNRLDQFGLAEPVVIQQGKEEISVQLPGIKTLEEERRAKDLISRSAHLQMMAVDEEHNKDAMKMTDLEAQKLGSVLLSDVEMGGKILLKAIPILDGEMLTDAKVVYDQNNQPVVSFTLDAQGAKIFGDFSGANVGKRMAIVLDNKVYSAPVIRERIGGGSGQISGNFSVAQASDLAIALRSGAMSAPIQVLEKRIIGPSLGKDSVKTSIIALVGGFILVMGFMVLYYSMAGVIACLALVVNLFLIVAVMAIFGATLTLPGMAGIVLTVGIAVDANIIINERIREVLRENEGIAKAIHLGYINASRAIFDSNITSLIASVLLYAYGTGAIKGFALTTGIGILASIITAIVGTQGIYQALLPKLTQTKSLYFWFGVNKRA
The following text describes a protein:
Function:
Mediates water and glycerol transport across cell membranes. Permeable to methylamine/methylammonium. Permeable to dihydroxyacetone.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MSDEKINVHQYPSEADVRGLKARNGGACEVPFEENNEPIPNRSANPQEKNENELVGDNADNEAHDAVDVNYWAPRQLRLDYRNYMGEFLGTFVLLFMGNGVVATTILDKDLGFLSIAFGWGIAVTMGLYISLGISCGHLNPAVTLANAVFGCFPWRRVPGYIAAQMLGAFVGAACAYGVYADLLKQHSGGLVGFGDKGFAGMFSTYPREGNRLFYCIFSEFICTAILLFCVGGIFDPNNSPAKGHEPLAVGALVFAIGNNIGYASGYAINPARDFGPRVFSAILFGSEVFTTGNYYFWVPLFIPFLGGIFGLFLYKYFVPY
The following text describes a protein:
Function:
Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to chromatin.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis. Is associated with chromatin throughout mitosis.
Sequence:
MPRRKALTNNNNAGEAEQQPPKAKRARIAFHLELPKRRTVLGNVLVCGNGDVGQLGLGEDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQDQKENVPVKVSGSSSISKKDKTPPQDNVDKEAENVDKQEQKENLPAKASTSSKKNKTPPQDNADKEAENVDKQEQKENLPAKASTSSKKIKTPPQDDAAEEVEEESAQEPTPKKAKKPAAKRGGKKT
The following text describes a protein:
Function:
Identified as a multi-copy suppressor of an FtsH/HtpX protease double disruption mutant. May play a role in the quality control of integral membrane proteins.
Subcellular Localization:
Cell inner membrane; Single-pass type I membrane protein.
Sequence:
MLIFIPILIFVALVIVGAGVKIVPQGYQWTVERFGRYTKTLQPGLSLVVPFMDRIGRKINMMEQVLDIPSQEVISKDNANVTIDAVCFIQVIDAPRAAYEVSNLELAIINLTMTNIRTVLGSMELDEMLSQRDSINSRLLRIVDEATNPWGIKVTRIEIRDVRPPAELISSMNAQMKAERTKRAYILEAEGIRQAEILKAEGEKQSQILKAEGERQSAFLQAEARERSAEAEARATKMVSEAIASGDIQAVNYFVAQKYTEALQQIGSSSNSKVVMMPLEASSLMGSIAGIAELVKDSANKRTQP
The following text describes a protein:
Function:
Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes. In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport. Required for very-low-density lipoprotein (VLDL) lipidation and maturation. Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles. Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles. May also activate apoptosis.
Subcellular Localization:
Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Cytoplasmic vesicle, COPI-coated vesicle. Note=Enriched at lipid droplet contact sites.
Sequence:
MEYLSAFNPNGLLRSVSTVSSELSRRVWNSAPPPQRPFRVCDHKRTVRKGLTAASLQELLDKVLETLLLRGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLEQGQSWSPKSGMLSYGLGREKPKHSKDIARITFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGVGPKRVLRELLRWTSSLLQGLGHMLLGISSTLRHVVEGADRWQWHGQRHLHS
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGVPHAFVERLNGHLETSRGFLSEHSTGTGRFLIKGSVAGGAVYLVYDQELLGSSDKSQAVLQKAEEVVPNAVYQFSQYVCEQTGLKLPQLPAPPKFNFHIRDSWNSGIITMMSALSVAPSKAWEYSKQGWEYLKEQTK
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEPWNLTGVSEFILLGFSEEPERQTLIIVFFLSMYLITVFGNLLIIMVTIYDSNLHTPMYFFLSNLSFADICFITMTVPKMLVNIQTQSKVITYAGCITQVYFFLFFSGLDIYLLTVMAYDRFVAICHPLHYMVIMNPRLCGLLLLVTWIISVLHSLLQSLMVLRLSFCTDLEIPHFFCELNQMVQLACCDTFLNNMVMYFAAVLLAGGPLAAILFSYSRIVLSICGISSAQGKSAAFSTCVSHLSVVSLFFCTSLGVYLSSAATHRSHSSAKASVMYAVVTPMLNPFIYSLRNKDIKGALKRLFGMAALQGPVVIGLKNCP