lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP. Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). In vitro, can use pGpG as an alternative substrate and hydrolyze it into GMP. Acts in regulation of motility, synthesis of virulence determinants and biofilm architecture. May act preferentially as a pGpG binding protein.
Domain:
Contains an unselective bimetallic binding site, with a high-affinity site (H-site) and a low-affinity site (L-site). Metal binding to the H-site triggers the binding to the L-site. This bimetallic center may play a structural more than a catalytic role.
Sequence:
MESMLDRPEQELVLVVDDTPDNLLLMRELLEEQYRVRTAGSGPAGLRAAVEEPRPDLILLDVNMPGMDGYEVCRRLKADPLTRDIPLMFLTARADRDDEQQGLALGAVDYLGKPVSPPIVLARVRTHLQLKANADFLRDKSEYLELEVRRRTRQLQQLQDAVIEALATLGDLRDNPRSRHLPRIERYVRLLAEHLAAQRAFADELTPEAVDLLSKSALLHDIGKVAVPDRVLLNPGQLDAADTALLQGHTRAGRDALASAERRLGQPSGFLRFARQIAYSHHERWDGRGFPEGLAGERIPLAARIVALADRYDELTSRHAYRPPLAHAEAVLLIQAGAGSEFDPRLVEAFVAVADAFAEVARRYADSAEALDVEMQRLEQAVAESIELTAPPA
The following text describes a protein:
Function:
May play a role in determining neuronal identity, may be directly involved in specifying identity of individual neurons. Required during embryogenesis for the process of body segmentation. Homeotic protein, required in alternating segment primordia, it specifies the correct number of segments.
Miscellaneous:
MISCELLANEOUS: 'Fushi tarazu' means 'segment deficient' in Japanese. Flies lacking ftz exhibit embryos with half the usual number of body segments.
Subcellular Localization:
Nucleus.
Sequence:
MATTNSQSHYSYADNMNMYNMYHPHSLPPTYYDNSGSNAYYQNTSNYQGYYPQESYSESCYYYNNQEQVTTQTVPPVQPTTPPPKATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQTHQQYDAYPQQYQHQCSYQQHPQDLYHLS
The following text describes a protein:
Function:
Binds gibberellin A3 (GA3) in vitro.
Sequence:
MIKEFNTQTTLNVGLEALWAAQSKDITLVVPKVLPNIVKDVQVIEGDGGVGTKLIFNFLPGIAPVNYQREVITEYDELSHTIGLQVVEGGYLNQGLSYYKTTFQFSAISENKTLVNVKISYDHESELIEEKVKPTKTSESTLFYLGQLEKFLLNGA
The following text describes a protein:
Function:
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRGVVWAARRRAGQQWPRSPGPGPGPPPPPPLLLLLLLLLGGASAQYSSDLCSWKGSGLTREAHSKEVEQVYLRCSAGSVEWMYPTGALIVNLRPNTFSPAQNLTVCIKPFRDSSGANIYLEKTGELRLLVRDVRGEPGQVQCFSLEQGGLFVEATPQQDISRRTTGFQYELMSGQRGLDLHVLSAPCRPCSDTEVLLAICTSDFVVRGFIEDVTHVPEQQVSVIHLRVSRLHRQKSRVFQPAPEDSGHWLGHVTTLLQCGVRPGHGEFLFTGHVHFGEAQLGCAPRFSDFQKMYRKAEERGINPCEINME
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Possesses 5'-pyrophosphohydrolase activity, hydrolyzing the 5'-end triphosphate to release pyrophosphates, and 5'-3' exonuclease activity. May be involved in RNA degradation in the nucleus.
Sequence:
MAENAGFISVPWGQHKLGAMYNTPFPSISRPKCIGVCSINASREFVDDASCASYLAGQPWPPLPFDLNGGIEDVIRKPVENGKRDLEIMLTYIKQHQKELLRQSSSDARNLRLDSDFVTLRGILRQIMCLQYDNRSFRVKATLLNGNVYMCKEETPEQQLENANMSRAQRVMCSWGFKFEQYLTSAQAQGKPVTNVPVNEAEEFMGVYRTNLAGILMLYGAELDCVDSKEPVDFKDCRVLDSLKFVELKTSVFNMNPHQIRTFKSFKSANWWSQSFLVGITTLYVGLRDTKGMLQRIDEIDVATLARNKPWSASAMAWYLEQFLRNLKKLLVNINDPFAVVQVTFLNKHASYEVLRGPEHQILPNWYRDLLKTRS
The following text describes a protein:
Function:
Converts oxalate to formate and CO(2).
Subcellular Localization:
Cytoplasm.
Sequence:
MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIFVPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRELHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFLLVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSVASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGAMRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGTETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT
The following text describes a protein:
Function:
Alpha-dioxygenase that catalyzes the primary oxygenation step of a variety of 14-20 carbon fatty acids, containing up to three unsaturated bonds, into their corresponding 2R-hydroperoxides. Involved in the production of oxylipins that function in cell signaling, wound healing, and protection from infection.
Sequence:
MSLVMDSLKNLLLSPLRGFIHKDFHDIFERMTLLSKLLFLIVHLVDKLNLWHRLPVLLGLLYLGARRHLHQEYNLINVGKTPIGVRSNPADHPYRTADGKYNDPFNEGAGSELSFFGRNMLPVDQHNQLKKPDPMVVATKLLARRNFVDTGKQFNMIAASWIQFMIHDWIDHLEDTKQIELKAAEEVASQCPLKSFKFFKTKEIPTGFYEIKTGHLNTRTPWWDGSAIYGSNAEVLKKVRTFKDGKLKLSADGLLEIDKNGKIISGDVRNTWAGLSALQALFVQEHNSVCDALKKEYPELEEEDLYRHARLVTSAVIAKVHTIDWTVELLKTDTLLAGMRANWYGLLGKKFKDTFGHVGGSILGGFVGMKKPENYGVPYSLTEEFTSVYRMHQLLPDKLQLRNIDATPGPNKSLPLTNEIPLEDLIGGKGEENLSKIGFTKQMVSMGHQACGALELWNYPVWMRDLIPQDVDGTDRPDHIDLAALEIYRDRERSVARYNEFRRGMLQIPISKWEDLTDDEEVINTLGEVYGDDVEELDLMVGMAAEKKIKGFAISETAFFIFLVMASRRLEADRFFTSNYNEETYTKKGLEWVNTTESLKDVLDRHYPEITEKWMNSSSAFSVWDSTPQPHNPIPLYFRVPPQ
The following text describes a protein:
Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Sequence:
MITRDFLMNADCKTAFGAIEESLLWSAEQRAASLAATLACRPDEGPVWIFGYGSLMWNPALEFTESCTGTLVGWHRAFCLRLTAGRGTAHQPGRMLALKEGGRTTGVAYRLPEETLEQELTLLWKREMITGCYLPTWCQLDLDDGRTVNAIVFIMDPRHPEYESDTRAQVIAPLIAAASGPLGTNAQYLFSLEQELIKLGMQDDGLNDLLVSVKKLLAENFPDGVLRPGFA
The following text describes a protein:
Function:
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity); On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells (By similarity).
Miscellaneous:
MISCELLANEOUS: In vitro, is a receptor for HIV-1 and SIV and transmits viruses to permissive T-cells.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Domain:
The tandem repeat domain, also called neck domain, mediates oligomerization.
Sequence:
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSISQEESRQDVIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCRRCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNEEGTWQWVDGSPLLPSFNQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
The following text describes a protein:
Function:
Part of the high-affinity ABC transporter complex ScaABC involved in manganese import. Probably responsible for energy coupling to the transport system. Essential for growth under Mn(2+)-limiting conditions.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MLRYINTVGVIYMIEIQNLSVSYQGQLALDKANVTIKGPTITGIIGPNGAGKSTLIKGLLGIVDHQGQALLDGQPLDKELKRIAYVEQKINIDYNFPIKVKECVSLGLYPKIKLFQRLKTSDWDKVNQALKIVGLEDFAERQISQLSGGQFQRVLIARCLVQEADYIFLDEPFVGIDSVSEEIIMKTLRQLRKDGKTILIVHHDLSKVVAYFDQVLLLNKKVVAFGSTESTFTKENMQQTYGSQLFMNGGA
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATEPKAAADDVKIDLFEDDDEFEEFEINEEWDDKEEGKEVTQQWEDDWDDDDVSDDFSLQLRRELESNTEKN
The following text describes a protein:
Function:
Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.
Miscellaneous:
MISCELLANEOUS: Encoded on a subgenomic RNA (RNA3) synthesized during replication and which is co-terminal with RNA1.
Subcellular Localization:
Host mitochondrion.
Domain:
The dsRNA-binding region is required for suppression of RNA silencing. The N-terminus is involved in homodimerization. The alpha2 helices of the dimer bind parallel to the stem of the dsRNA helix.
Sequence:
MPSKLALIQELPDRIQTAVEAAMGMSYQDAPNNVRRDLDNLHACLNKAKLTVSRMVTSLLEKPSVVAYLEGKAPEEAKPTLEERLRKLELSHSLPTTGSDPPPAKL
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MVPPADQTMAKETVLATKLVAEFESFGVIIDDLGIIDNLRAMCKLYSLDESTMVDEWMAFACSSGNDIEITHSALESFEKELSAYRLSILASRLDREEHSLIDAYCTPEMKASKRLLKTPESDSRKLIKTPYKRTPASQIFSPNSYSPNMYSSRGNAGEILATLNMCGINDETINWKGHGIKTNVTAADPDQCLDEGYRYMFQKISERIEALRHQVSLVAEPLQEQHGIQELGYVDVPSQDGTTVIGRIGCDSNGRLNAASLVIAGYNPNRVCRSATPLNVKELSHFSFFPGQVVVLDGKNPSGNAFIASKLYQGIALPFNKIPLEKAKSYYPSDDSPMNILVACGPFTTADNLLYEPLSDLLKVILNQQPDIAILCGPFVDAKQELIKQGEINISYEDLFIKRLSEIIENVGRISTSVVFVPSTRDVHHDFIYPQPPFTLPSSLKTAPEIHFVSDPCTLIVNDVTIGLTSTDILFHMGAEETASPPGMSDRIGRLLKHLIHQRNYYPLYPPSEEVNFDRENFVNFGFMPVTPDILIVPSDLRYFVKDVEKCCCVNPGRLAKGQVGGSYARIAVLPPKVANQPVIDRIVSQVVRI
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MAELLSREIRYLQHPPHQQQQHLNHLGHGGSGQRLIEEYIVTQQIGSGSFAVVWKGHHNQYPAREVAIKEIATEKLNKKLQESLRSEIAILRKTDHPNIIRLHDIVEGPNRIYLVLEYCAGGDLAAYIQRCGKVNEATARNFMRQLGDGLRVLRNNYWIHRDLKPQNLLLSTNDDNAVLKIADFGFARSLMPQGMAETLCGTPLYMAPEILQSKKYDAKADLWSVGAILFQLVTGRPPFSGNNHVQLLQNILKSPEVRFPEPIMAQLHPDCIDMCRKLLRKDPVERLAFEEFFAHSFMEEMRPKKEDAQAGGSLSGGTGGKSETSQKGCFPFLLDDEQQGSVYGKLSRPPLFSPLPPSSSFLPFGKKSNAGHSPPTRTGFPVTRFHDNRSRILNSGAEDSAVMGGDHSSTHSGSSTEGALGDSFDTIEREYVLVKVPITSTDNLGTSLSTSDAGGIQLSGKGISSFPHRVHNLNVGPTSSGRVGSGASSGSVLSHSSQEFEAPSQHPPTRLSSLQISARLITELAVDKMNVGLRVEAFSIQLVCLAIWKEALRVCQTWADSEHVGSSGGKGSSEDVESQDRSIANTCSFMEREFSFAVERAESLAVHINTGDVGRRIATSAEMPDALELIFQSALALGKEGAVDELMGSMSNASSAYEKAAALLYFLVVEAATLPIQPPLLLSDIDRHRLRRYYDNITARHHQCAATAQIHHTFLADT
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAQGSVSFKDVTVDFSQEEWQHLDPAQKTLYMDVMLENYCHLISVGCHMTKPDVILKLERGEEPWTSFKGHTCLEENWKAEDFLLKFKEQQDKYSRSVILINHKKLVNENGSTCEKTLTLSKNPINSKKLPPEYDTREKILKNVSELIISNLSPTRRRLSECNGYGKSLLNTKPETAHSGVKSHNQCGRTISHNEKITQYHKMETPAQSFEYNDCEKAFLKRGGPVTHSRTYRRGNTSDYNKRRRTTNIEKKHTCTECGKSFCRKSVLILHQGIHTEEKPYQCHQCGNSFRRKSYLIDHQRTHTGEKPFVCNECGKSFRLKTALTDHQRTHTGEKSYECPQCRNAFRLKSHLIRHQRTHTGEKPYECSDCGKSFRQKTTLSLHQRIHTGEKPYICKECGKSFHQKANLTVHQRTHTGEKPYICNECGKSFSQKTTLALHEKTHNEEKPYICNECGKSFPQKTTLVAHQRTHTGEKSYECPHCGKAFRMKSYLIDHHRTHTGEKPYECNECGKSFSQKTNLNLHQRIHTGEKPYICNECGKSFRQKATLTVHQKIHTGQKSYECPQCGKAFSRKSYLIHHQRTHTGEKPYKCSECGKCFRQKTNLIVHQRTHTGEKPYICNECGKSFSYKRNLIVHQRTHKGENMEMQ
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MLDYGWGNPSSIMLSGDDNHQDSDQNRSIFDPYATQNFSDAANFMNPPETHHYSAVPTNDNPHNHHQLPFHHQNPNSSNHFTSFYDSRAYSAAASSYQHHPHAAAAAASMLTLEPAGGQTGYMMVPKSEPVNVGGLEYNSRIGLNLGGRTYFASSEDDFVNRLYRRSRALEPGSMNSPRCQAEGCNADLTHAKHYHRRHKVCDFHSKASTVIAAGLTQRFCQQCSRFHLLSEFDNGKRSCRKRLADHNRRRRKSQQPSQENPNKSHQLIESTATNSSSENLATRSPPDSGHHSSSVTVAVSPPRISLDCFGQRSYIGGTTSSTSSTSSLFYSNG
The following text describes a protein:
Function:
Vertebrate selective toxin that causes pain by targeting tetrodotoxin (TTX)-sensitive sodium channels in peripheral sensory neurons. Converts the normally rapidly activating and inactivating sodium channel current into one that does not inactivate. Is active on both Nav1.6/SCN8A and Nav1.7/SCN9A, with a much potent activity on Nav1.6/SCN8A (EC(50)=196 nM on human channels) than on Nav1.7/SCN9A (EC(50)=1.9 uM on human and EC(50)=1.2 uM on mouse channels). On these channels, causes a sustained current, an increase in peak current amplitude and a hyperpolarising shift in the voltage-dependence of channel activation. Toxin-induced hNav1.6/SCN8A and hNav1.7/SCN9A persistent currents are slowly reversible with repeated wash steps over 30 minutes. In vivo, intraplantar injection into mice causes dose-dependent spontaneous nocifensive behaviors which are gradual in onset, reaching near maximal at 30 minutes post-injection. These nocifensive behaviors decrease with coinjection of TTX. When tested on insects, intrathoracic injection into blowflies (Lucilia caesar) does not cause paralysis or death (up to a dose of 200 nmol/g).
Subcellular Localization:
Secreted.
Sequence:
MKVLKFLFIAVIIVGLSGSLTWASPIANARAEADAEAAAEAVAKAVAEAVLPALPLLAGLMSLPFLQHKLTNG
The following text describes a protein:
Function:
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Partially recruited to lipid rafts upon BCR stimulation.
Domain:
The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.
Sequence:
MENQPVRWRALPGLPRPPGLPAAPWLLLGVLLLPGTLRLAGGQSVTHTGLPIMASLANTAISFSCRITYPYTPQFKVFTVSYFHEDLQGQRSPKKPTNCHPGLGTENQSHTLDCQVTLVLPGASATGTYYCSVHWPHSTVRGSGTFILVRDAGYREPPQSPQKLLLFGFTGLLSVLSVVGTALLLWNKKRMRGPGKDPTRKCPDPRSASSPKQHPSESVYTALQRRETEVYACIENEDGSSPTAKQSPLSQERPHRFEDDGELNLVYENL
The following text describes a protein:
Function:
Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLRRSGCFLNMGLGDEYVKKVFNSVASKYDMMNDVLSLGIHRLWKREFVRDYVRPCPGGSYVDVAGGTGDIAFRIIDEVRQLERGLPGLTPPDFRGVGVTVVDINEQMVHEGEARAAREGYDGLEWIVASGEELPLDDMQFDGYTVSFGLRNFSDRPKALREAHRVLKVGGVLSVLEFSKVTCSLLRVPYDVWSYGFIPQAGRILANEESYRYLVDSIRAFPDQETLAEMIREAGFGYVRYDNLSGGIACVHTAVKTEAVPIHKPKSEVENAMAQQERVVEDSKVGAA
The following text describes a protein:
Function:
Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (By similarity). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Myelin membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=In polarized cells, localized predominantly in the apical membrane (By similarity). Located in lipid raft (By similarity). Recycled between the plasma membrane and the Golgi complex (By similarity). PLLP is continuously recirculating in the cell (By similarity).
Sequence:
MAEFPSKVNTRTSSPAQGGGAVVSTLSPDLGFVRSSLGALMLLQLVLGLLVWALIADTPYHLYPSYGWVMFVAVFLWLVTIIFFVLYLFQLHMKLYMVPWPLVLMVFNVGATVLYITAFITCSASVELTSLKGSQPYNQRAAASFFSCLVMIAYGVSAFLSFQAWRGVGSNAATSQMAGGYA
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVTMADITKLRKMTGAGMMDCKNALTEAEGDYDKAMEIIRKKGQAVAAKRSERDASEGCVLAKTTGDYAVVIALKCETDFVAQNADFVKLTQDILDLAVANKCKTLDEVKALPMGNGTVQDAVVDRSGITGEKMELDGYMTVEGTSTAVYNHMNRNGLCTIVAFNKNVDDQLAKQVAMQIAAMNPIAIDEDGVSEEVKEKEIAVAIEKTKAEQVQKAVEAALKKANINPAHVDSEEHMESNMAKGWITAEDIAKAKEIIATVSAEKAAHLPEQMIQNIAKGRLGKFLKEVCLLNQEDIMDAKKTVREVLAAADPELKVLDFKRFTLKAE
The following text describes a protein:
Function:
During nodulation, plays a central role in nodule organogenesis. Involved in the perception of Nod factors, the first step of recognition of rhizobia prior to nodulation. Necessary in epidermal cells to induce cortical cell divisions leading to nodule primordia formation. Required during root nodule symbiosis with Sinorhizobium meliloti by triggering infection threads and release of bacteria into the cytoplasm of cells in the infection zone of developing nodules, especially in cells derived from the meristem. Promotes plant fitness (e.g. fruit weight and leaf number); Involved in resistance to oomycetes (e.g. Aphanomyces euteiches) and to fungi (e.g. Colletotrichum trifolii).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Vacuole lumen. Note=Removed from the plasma membrane upon the release of rhizobia into the host cytoplasm. Vacuolar localization is observed in cells undergoing breakdown of the receptors.
Domain:
LysM domains are involved in Nod factors perception, especially in chitooligosaccharide-binding.
Sequence:
MSAFFLPSSSHALFLVLMLFFLTNISAQPLYISETNFTCPVDSPPSCETYVAYRAQSPNFLSLSNISDIFNLSPLRIAKASNIEAEDKKLIPDQLLLVPVTCGCTKNHSFANITYSIKQGDNFFILSITSYQNLTNYLEFKNFNPNLSPTLLPLDTKVSVPLFCKCPSKNQLNKGIKYLITYVWQDNDNVTLVSSKFGASQVEMLAENNHNFTASTNRSVLIPVTSLPKLDQPSSNGRKSSSQNLALIIGISLGSAFFILVLTLSLVYVYCLKMKRLNRSTSSSETADKLLSGVSGYVSKPTMYEIDAIMEGTTNLSDNCKIGESVYKANIDGRVLAVKKIKKDASEELKILQKVNHGNLVKLMGVSSDNDGNCFLVYEYAENGSLEEWLFSESSKTSNSVVSLTWSQRITIAMDVAIGLQYMHEHTYPRIIHRDITTSNILLGSNFKAKIANFGMARTSTNSMMPKIDVFAFGVVLIELLTGKKAMTTKENGEVVILWKDFWKIFDLEGNREERLRKWMDPKLESFYPIDNALSLASLAVNCTADKSLSRPTIAEIVLCLSLLNQPSSEPMLERSLTSGLDAEATHVVTSVIAR
The following text describes a protein:
Function:
Required for the assembly of the TOM (translocase of outer membrane) receptor complex, which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MAEEILGNIAEEAHAALLASAGDEATKKSGAIRLPIEDSLDGDFGSRGTAYTDLSTTTSAGTSGQLVERTGGISFGRLLSVAGSCSINLLLPFLNGLMLGFGELLAHELSWKFSWFDKERNRGYRIYPEVRKAAELQERERQRALSRAAGPDGFL
The following text describes a protein:
Function:
K(+)-specific ion channel. May play a role in the defense against osmotic shock.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSHWATFKQTATNLWVTLRHDILALAVFLNGLLIFKTIYGMSVNLLDIFHIKAFSELDLSLLANAPLFMLGVFLVLNSIGLLFRAKLAWAISIILLLIALIYTLHFYPWLKFSIGFCIFTLVFLLILRKDFSHSSAAAGTIFAFISFTTLLFYSTYGALYLSEGFNPRIESLMTAFYFSIETMSTVGYGDIVPVSESARLFTISVIISGITVFATSMTSIFGPLIRGGFNKLVKGNNHTMHRKDHFIVCGHSILAINTILQLNQRGQNVTVISNLPEDDIKQLEQRLGDNADVIPGDSNDSSVLKKAGIDRCRAILALSDNDADNAFVVLSAKDMSSDVKTVLAVSDSKNLNKIKMVHPDIILSPQLFGSEILARVLNGEEINNDMLVSMLLNSGHGIFSDNDELETKADSKESAQK
The following text describes a protein:
Function:
Alkaline phosphatase with broad substrate specificity. Precipitates uranium from alkaline solutions.
Subcellular Localization:
Secreted.
Sequence:
MLKHVAAALLLATAMPVVAQSPAPAAAPAPAARSIAATPPKLIVAISVDQFSADLFSEYRQYYTGGLKRLTSEGAVFPRGYQSHAATETCPGHSTILTGSRPSRTGIIANNWFDLDAKREDKNLYCAEDESQPGSSSDKYEASPLHLKVPTLGGRMKAANPATRVVSVAGKDRAAIMMGGATADQVWWLGGPQGYVSYKGVAPTPLVTQVNQAFAQRLAQPNPGFELPAQCVSKDFPVQAGNRTVGTGRFARDAGDYKGFRISPEQDAMTLAFAAAAIENMQLGKQAQTDIISIGLSATDYVGHTFGTEGTESCIQVDRLDTELGAFFDKLDKDGIDYVVVLTADHGGHDLPERHRMNAMPMEQRVDMALTPKALNATIAEKAGLPGKKVIWSDGPSGDIYYDKGLTAAQRARVETEALKYLRAHPQVQTVFTKAEIAATPSPSGPPESWSLIQEARASFYPSRSGDLLLLLKPRVMSIPEQAVMGSVATHGSPWDTDRRVPILFWRKGMQHFEQPLGVETVDILPSLAALIKLPVPKDQIDGRCLDLVAGKDDSCAGQ
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MATNQHDLERIRQQIVLANIQELIKKMTRRCFDVCIAMPEMELRSTERDCLANCMDRFMDSVQVVSSQYFRRRRRHQQIRLSRSTASSASPPASASASMPKSAAANESESASRASNDEKVK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose in xyloglucan degradation, leading to remove the backbone 'G' units.
Miscellaneous:
MISCELLANEOUS: Gut bacteria supply the human body with energy from dietary polysaccharides through glycosidases that are absent in the human genome. Xyloglucans are a ubiquitous family of highly branched plant cell wall polysaccharides present in the vegetables we consume. Enzymes involved in xyloglucan degradation mediate the conversion of otherwise indigestible plant polysaccharides to short-chain fatty acids.
Subcellular Localization:
Periplasm. Note=Periplasmic localization is predicted by analogy with the archetypal sus locus.
Sequence:
MKNIKKMVLVSAFAGTCLTPHAQTASPVIPTDPAIETHIREWLQKMTLEQKIGQMCEITIDVVSDLETSRKKGFCLSEAMLDTVIGKYKVGSLLNVPLGVAQKKEKWAEAIKQIQEKSMKEIGIPCIYGVDQIHGTTYTLDGTMFPQGINMGATFNRELTRRGAKISAYETKAGCIPWTFAPVVDLGRDPRWARMWENYGEDCYVNAEMGVSAVKGFQGEDPNRIGEYNVAACMKHYMGYGVPVSGKDRTPSSISRSDMREKHFAPFLAAVRQGALSVMVNSGVDNGLPFHANRELLTEWLKEDLNWDGLIVTDWADINNLCTRDHIAATKKEAVKIVINAGIDMSMVPYEVSFCDYLKELVEEGEVSMERIDDAVARVLRLKYRLGLFDHPYWDIKKYDKFGSKEFAAVALQAAEESEVLLKNDGNILPIAKGKKILLTGPNANSMRCLNGGWSYSWQGHVADEYAQAYHTIYEALCEKYGKENIIYEPGVTYASYKNDNWWEENKPETEKPVAAAAQADIIITCIGENSYCETPGNLTDLTLSENQRNLVKALAATGKPIVLVLNQGRPRIINDIVPLAKAVVNIMLPSNYGGDALANLLAGDANFSGKMPFTYPRLINALATYDYKPCENMGQMGGNYNYDSVMDIQWPFGFGLSYTNYKYSNLKVNKPTFNADDELIFTVDVTNTGKVAGKESVLLFSKDLVASSTPDNIRLRNFEKVSLEPGETKTVTLKLKGSDLAFVGYDGKWRLEKGDFKIKCGDQWMDIVCDQTKVWNTPNKNTLHK
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPGPAPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS