lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MDPDEFLTGGSYAPMPGGPGNEMHPPGKGRARIGGEEAQPLVGGEPENILGGESFKWDLISDLDHFFARLYHYYCNKGFWCIVTQWVVELLTLGFTIVFSGFLILFVNWPWLLQAKCGIQAAEAGHEPCDLVREGLVRHPLVPMTFLKAMAVVYLAMFSAFWAFCFARFFLQLRELLEVRDFCHARLGVGEKELQTMSWPDLVDRVVRFQSRQRLCIVKELSAHDIVSRIMRKENYTIGMLNKNVLALEMPRWVPGAAPLPGFAGTRKPGRRKNRTRHLVLTKTLEWSLNWCILHHMFDANFAIRRDFVRDPERLKRRLRMVGVGMALVSPFLVVFMLMYFFMRNAEQFYHQPGTVGSRRWSNLAKWRLREFNELDHLFQRRLNASYQHAVAYVKQFPSPIVSMVAKFVSFVTGACAAVLLGVALLDESLLEAQLFERNLFWYAAIFGTILAVSRSLITEEFTVFDPEAVMQYTARYTHYMPKHWRGKANTDAVRGEFEALFQFKFVLFFEEMASIFITPFLLWFYVPKCVDSILRFVEDFTTQVDGVGDVCSLSAFDFAHHGNSKYGSPCDAVKDQRSTQGKMEKSFLSFVSNYPTWEPPPNGQKMLGMLSTFRTRNEAASSAFPLTSSVLRNSAPYYPPRAAMSHHFSGSYRKVASRHGADGAGGGFGHRLPMPSGGDHPDPAIDSHLAASGALATMGANPEEATQLYWLDRYYEAARATGSGIELDPLSKNGGGETEVSDGGAHLRPAHSGDDVTRDGRFEGADRPMETRVMISDGRGGGLAGAARALDGQNVRSDGRGTGSDGRILGSDGRLLGSDRRTAGSDNRVLGPDARSFAADGRALGLDARTRRGPMSESEMDRVLVDQALQRNAVRGRGVDFGVASVMEEPEEEEDDFSQPDLLQPHPFGLNASSAHNDPWPSFGSMQREGAGRADPTGVTSIRFGSGHASGRPGGSSRGPWGLVSGQESGFGLEEEAAPPATGPFARLHDDFGASSVFSERRPRGRSWAGSGSLRGSGSQGGFGRTRERSRGSWDGEAEESFAEKGVGVNNEQSDSQGQSGLWHDGEETTGVWGEGQSGEGEGRPVRRSFS
The following text describes a protein:
Function:
Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Probably acts as a peripherally associated component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruits late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Regulates the membrane association of VPS4. Can stimulate VPS4 ATPase activity directly or via VTA1.
Miscellaneous:
MISCELLANEOUS: Present with 2440 molecules/cell in log phase SD medium.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosomal and other punctate structures.
Sequence:
MSRNSAAGLENTLFQLKFTSKQLQKQANKASKEEKQETNKLKRALNENEDISRIYASNAIRKKNERLQLLKLASRVDSVASRVQTAVTMRQVSASMGQVCKGMDKALQNMNLQQITMIMDKFEQQFEDLDTSVNVYEDMGVNSDAMLVDNDKVDELMSKVADENGMELKQSAKLDNVPEIKAKEVNVDDEKEDKLAQRLRALRG
The following text describes a protein:
Function:
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Sequence:
MKQFGGPVLFLDRSDINTDEIIPAKYLTEITKEDLKPYILEDLKLPGFDPKGEKTKTARVVVSRANFGCGSSREHAPWVFEVNGITAVIAESFARIFRQNMFNCGMAAIELSADTIEGLFTYAGCADAAISIDVAGQTLTISGGGTSETHSFDISPFDKALVLAGGWVDYADSKY
The following text describes a protein:
Function:
Involved in secretion. Component of the secretory vesicle docking complex.
Miscellaneous:
MISCELLANEOUS: Present with 1380 molecules/cell in log phase SD medium.
Sequence:
MMSQVSHSQEGSGRFWNKFKSSTKSLSTSLAHLSIKAEKDGDTVNTTLVHKGLVKFYENQHPFQGFPGWLGEKEDLPNERKILDTQVKHDMKKQNSRHFSPSFSNRRKASSEDPMGTPSSNGNTPEYTPASKSFQDIYNNHTSSSSATPRRASSRPTRPSAGQEFRASLGRSKTSNSFNTSSTPTPPPDASSGVMAMKDRLKRRNNDYGF
The following text describes a protein:
Function:
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Subcellular Localization:
Secreted.
Sequence:
MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLLEYQKSNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQRKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKAPPEWKALTDMPQMRMELERPGRNEITRGDSTSYGTGSETESPRNPSSAGSWNPGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGIWNPGSSERESAGHWTSESSVSGSTGQWHSESGSFRPDSSGSGNARPTNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELTTGKEKVTSGSTTTTRRSCSKTVTKTVIGPAGHKEVTKEVVTSEDGSDCPEAMDLGTLSGVGTLDEFRHRHPDEAAFFDTASTGKTFPGFFSPMFGEFVSETESRGSESGIFTNTKESSSHHPGLAEFPSRGKTSSHSKQFTSSTSYSRGGSTFESKSYKMADEAGSEADHEETHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLLTQ
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MTGWNQKMAKMAFRRSKFRRLAWGDGDPYPYTPRATFRYQWDDWPLWEKIWHIGIGIVGVEFAMWAYYSKLNSRMDWAREEALRRMRLRREAQELMILEGEKFDSDIQPDRR
The following text describes a protein:
Function:
Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MVAALLCLNIEHYHTRNVSALQQQCKYASALAVSIANTGILSKSGFPSISEILDGILFAAVPKNRRSREKRAKRRFGCHKVREYMTPKTNIVVCLNCGHYHESHTLCGHCYDKVKNQTPSNRENLL
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Thr)(GGU). The methyl group of m(6)t(6)A37 appears to slightly improve the efficiency of the tRNA decoding ability. Binds to tRNA.
Sequence:
MNDLTLSPIAIIHTPYKEKFSVPRQPNLVEDGVGIVELLPPYNSPEAVRGLEQFSHLWLIFQFDQIQQGKWQPTVRPPRLGGNQRVGVFASRATHRPNPLGLSKVELRQVECINGNIFLHLGAVDLVDGTPIFDIKPYIAYADSEPNAQSSFAQEKLPVKLTVEFTEQAKSAVKKREEKRPHLSRFIRQVLEQDPRPAYQQGKPSDRIYGMSLYEFNVKWRIKAGTVNCVEVIEIEKDK
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MQSINLHIKNFPPEINLEPNQADQYWDQVGRSIETNNIRISIPNHNQTPKLDIRGYGPILAQHTTFRMDPSNSHSMSKSSPTALRSLIWEGSIPISFVLEPSELPPGSDRGVEAFYTSAPRMSYLSLLVPIVKSNLIGLCLDDNALFTLKEENIWFEHAPSKVALKWHWPIGLIYDTLLASLPASSLGLPLQVTVHLNPVPADKGLLPNAVSVCREAFMSQVKEADFVRWGSTRRVTNLRQREAESLWEGLVEHDFDKFWLVASKLIPIPPSPSSLHSAPMTPAQPTNSSIDRMPDGNGVRNVPMRIYLPDNIPVMQAQSGPVDENGRRVTLGAALADLAPSLFPEPSSTSKRRLARAFIQGVQVPLETELGWLGAVMCCADGWVAVVIHLGR
The following text describes a protein:
Function:
Substrate-recognition component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium. Specific for substrates with an N-terminal Pro (Pro/N-degron).
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Colocalizes with FBPase-containing vesicles.
Sequence:
MKGCSFLRNGAKFQGKQKGVSSSTLEVHVTILHVNLAKSMLCGFIHVSYTSPNNTSLTTYFEAEIIGNRFTFETKWPEWGASEEIDNRHWKRLGALKSNGKDIPLRLIQPYDPLSRETVYMRWKELAMLDKTVDYQNHNQSFPFGISYEGFYYISFSQSTGKIKGYYYHHSEPEKVLFLELNPIIDRTFPVIEFQ
The following text describes a protein:
Function:
May be involved in different biological processes including transcription and apoptosis by sequestering specific proteins outside of the nucleus (By similarity). Involved in actin stress fibers formation probably through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MTIMAQVLHMDSSFPGKINPPVPPSLHAKDQEAPYSVETPYGYRLDLDFLKYVNDIEKGNTIKKVPVQRRPRYGSLPRGYGYTGSWWTSTESLCSNASMDSRHSSYSYCAPGFHTSQRPNFSTARVEKTLMDARRKLEEEKDGRRFSNLGSMHSSMAGSNTSLSSAHSFNRAQGGGSYTPMSSGLSTPVSPTPAHLQHVREQMAVALRKIRELEEQVKTIPVLQVKISVLQEEKRQLSVQLKSQKFLGHTLGFNRSRPRGELYIDIPEEEAGNGAGAANKATGSLSPTTPGSLQDSGCEIEETVIVAGARPGAKREVRTVGVGPEAEERGYRQVGVGVREQDLGLLPETEALKTKVGLLEVQLRKTMQELQSAQQQVEAAQKERQTVCPQVDHAVRATSLGWQDQQGQAGAGLHTVVSFTKQPHQQRTVGIQVYTLEQPTVVGVGTLLRAQGCTHPAQLEASHRRYGESPAAGDSPHEFPIAISSKQVREVLRSEVSKSVPVTNQATPMETKCNQVTAVCQRLKEGEINQQPAEEAIQVDPANPASPQSNLRSIMKRKADGEPGSPYTKKNLQFLGVNGGYESTSSEESSSESSEDESDASEYHEATEKLPESATPQSLVSSCIPQLASETPATQTAQHSTAQIPTNHTPAAQTTSQSHTTDATTQQHVTQSPAAEADVQHCVSQSSVTTTPPPEGDVQCVFQGCNPPSTATSLEQNSVQLSSATQQSKATDSNVQPDLAQTDVSDFAAQQTTTQTQFTSAKPQQEASQSKTADLTAQKGATHSTDGSAKQDIAISSTTKPAADTATPPTNKQTDSLELSGGLMSALHILQKALSEPNAFSHQDARTAYTSVLQEWLRVSCHKAADTAVVKAHMDAFASISPQLLEFVINMADGNGNTALHYTVSHSNFPVVKLLLDTGLCNADKQNKAGYTAIMLTALAAFSSDSDLQTVLQLLRTGDVNAKASQAGQTALMLAVSHGRGDMVKALLACGAQVNLRDDDGSTALMCACEHGHVDIVRQLLSVPGCDATLTDNDGSTALSIALEASQNDIAVLLYAHLNFAKPPSPVSPKSPILGSSPPSSSELK
The following text describes a protein:
Function:
Involved in multiple sites RNA editing events in mitochondria. Essential for C-to-U RNA editing at seven specific sites of nad2, nad4, cox2, cox3 and ccmC transcripts, all coding for proteins involved in the mitochondrial electron transport chain coupled to ATP generation. Required for normal growth and development.
Subcellular Localization:
Mitochondrion.
Sequence:
MSVSAAARHLESLLPRLASLRHYLQFHARLLTSGHLGAHPGLRARFLDRLALSPHPAALPHALLLLRSLPTPATNDLNAALRGLAASPHPARSLLLLAGRLLPALLPRPDALSLSFALKASARCSDAHTTVQLHALVLRLGVAADVRLLTTLLDSYAKCGDLASARKVFDEMTVRDVATWNSLLAGLAQGTEPNLALALFHRLANSFQELPSREEPNEVTIVAALSACAQIGLLKDGMYVHEFAKRFGLDRNVRVCNSLIDMYSKCGSLSRALDVFHSIKPEDQTLVSYNAAIQAHSMHGHGGDALRLFDEMPTRIEPDGVTYLAVLCGCNHSGLVDDGLRVFNSMRVAPNMKHYGTIVDLLGRAGRLTEAYDTVISMPFPADIVLWQTLLGAAKMHGVVELAELAANKLAELGSNVDGDYVLLSNVYASKARWMDVGRVRDTMRSNDVRKVPGFSYTEIDGVMHKFINGDKEHPRWQEIYRALEDIVSRISELGYEPETSNVLHDIGEEEKQYALCYHSEKLAIAFGLIATPPGETLRVIKNLRICGDCHVVAKLISKAYGRVIVIRDRARFHRFEDGQCSCRDYW
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNIYPLVICGPSGVGKGTLIKKLLNEFPNYFYFSVSCTTRKKREKEKEGVDYYFIDKTIFEDKLKNEDFLEYDNYANNFYGTLKSEYDKAKEQNKICLFEMNINGVKQLKKSTHIKNALYIFIKPPSTDVLLSRLLTRNTENQEQIQKRMEQLNIELHEANLLNFNLSIINDDLTLTYQQLKNYLLNSYIHLNNHTRN
The following text describes a protein:
Function:
May play an important role in the terminal differentiation.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cytoplasm, cell cortex. Cytoplasm, perinuclear region.
Sequence:
MNKLKFLIILFITFLFNLKYINSLKQCKISVLLSGDWSDMGYNYQMNNARIKAESALNLEMSLCYKNLEVSIDLAKQAIEDSIKKGANFIVISSSVHTSIGYEYARLHRDKDIYWLIRGRGRPVPDDLPKVAVINFNTHLLHYTLGLVSGYLTTSGTVGFISPGPQILALANSNSFYLGALASRKNVTFLNAYTGSWYNPEVAYKASQMLISNGADFIGMSQDDMSVQKALMDSGKMALGITGFSNRLIWGSDIALSYITDWSDVFIKYAGHILNDTWPEYTDYYTTLAEGGSLLFDTFSYRVPSEVQKLVSLEIEKLKNSSYQPFRCNPMYSQINLNFDSNGCANDMEFKNTKLLLKGTDISKTINLGLYTIPIEFVDYSNSMKLGLTIVSGFCILFCIISMVLVIMFRHAKIIKSASPIFCLLILFGCIIIFSGCIIFSLSPTDGICGARVWLLSIGYTIFLGSLLVKNWRIWLLFDNPKLKKRSITNWKLYPFVAGILAADVLILALWQGLGDIRSESRIGIDSLTKYQYANVCSSNDQGSVALYILLVFHGIKLLAACFISFKIKAVDIEEFNESKPIASSIYIITFCLFIVIPLMVSPQSVASQVITIVVCAIVTTLISISLLFGSKFYMMATQGLALNQTFATNTKSSSFSLSLEKQKSKSNGLEFEDSDESEEKLPQIKNYSNSEIPNLQHNHSRLAHFSSDSCTSAEQDSKLDLENQNDENEIENNQNNQNNIVEDCQKVEKLEKDENLEKDENLEKDENLEKDNENQSIIQKKRLSKNFNQSEIDPDDV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNLDSLSKIIKNKIQNVLYPTSKALLSSDDPSKRAETCYDLSQKIEEFELVCDELYGIIEIHKQNVIFSNINNGTHISKENNPEVLFNSLVSRLSTLRQTKSTMDSFAKEISIVQPIDNKANTNNNNNNNNNNNNNNNNNNNNNNNTNTNTNNTNNTNNTTNTNNTNNNNNNNYNNNNNNNNNNNNNNNNNNNNNNNNSINNSINNNSNNKVGSNDNPSTAPITENNTENNAGNTNNTNNNNNNNNNNNNNNNNNNNNNNNNTNQVAESSNISSNTTPPETTNIVNDPNSVSGGNLTNTEAPMEISDNSEIQHPQQEQQQQQQQQQQQQQQQQQQQQQPQEQIPQQQQPQLPMQQEQIQQLPQQQTPPSQQQPQQTPPLPQQFQQPLVNVNQITSPTLENQSISGNNNNNNDGQTISPQQQQEQLQLQMQQLQQLQMQQQQMNFNPTEPINTNFYNIDLQQPIQQQTLNNNNNNINSLENQINTNLGGNTFNTGTTPPLQQQPQPQQQQQINNPEINQIDDDNTMKETIDVDKIIEESNNVNNNVNNRQVIDLE
The following text describes a protein:
Function:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGYLLTIACYIASFSPSIALFCSFIAHDPVRIILFFLGSFFWLVSLLFSSLAWLGLSTVLPDTFLLSLTVCIIAQELSRVAYFMLLKKAQRGLNKITRQGQISVAPGVSDLHNARHMLALVCGLGMGVISALFYTMNAFAIFSGPGTIGLPNALKTGEIDTNRAGKYLPLCYTLSAILLTLFHVTWTIMVWDSCHKIGRIPSAFVPGAAAVVSHLLVTFLSSLNSRGFHVLVFAVQFLILLICIAYCNVIMGGTISSFVNGIGQSITDAVTLKQVRTLIEERKLRTQRQSVPDEPMTERAGTSNTVNA
The following text describes a protein:
Function:
Probable electron transporter.
Domain:
The structure is significantly stabilized upon cofactor binding.
Sequence:
MAEIGIFVGTMYGNSLLVAEEAEAILTAQGHKATVFEDPELSDWLPYQDKYVLVVTSTTGQGDLPDSIVPLFQGIKDSLGFQPNLRYGVIALGDSSYVNFCNGGKQFDALLQEQSAQRVGEMLLIDASENPEPETESNPWVEQWGTLLS
The following text describes a protein:
Function:
Positive regulator of amino acid starvation-induced autophagy.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm, cytosol.
Sequence:
MRRRVFSSQDWRASGWDGMGFFSRRTFCGRSGRSCRGQLVQVSRPEVSAGSLLLPAPQAEDHSSRILYPRPKSLLPKMMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAVKEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the oxidation and isomerization of cholesterol to cholestenone (cholest-4-en-3-one), an initial step in the cholesterol degradation process. Contributes to virulence. ChoD does not appear to play an essential role in cholesterol degradation in M.tuberculosis, and is probably important for pathogenesis not as a cholesterol-degrading enzyme, but rather as a virulence factor. Required for interference with the host Toll-like receptor 2 (TLR2)-mediated signaling pathway and subsequent intracellular growth and survival of the pathogen in human macrophages. Acts as a virulence factor that enables M.tuberculosis to disturb the TLR2-mediated signaling pathway in macrophages and modulate their immune response. May favor Th2 and proinflammatory response rather than Th1 immune response in vivo.
Miscellaneous:
MISCELLANEOUS: Can successfully induce the immune response both in vitro and in vivo.
Subcellular Localization:
Secreted.
Sequence:
MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLNYANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEPVRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIPIGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSNAG
The following text describes a protein:
Function:
Receptor kinase involved in the regulation of thermotolerance. Functions as a positive regulator of heat tolerance. May be involved in the regulation of cell proliferation and cell growth.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MTPAPAAASYRALVALLLVAVAVADDGSTLLEIKKSFRNVDNVLYDWAGGDYCSWRGVLCDNVTFAVAALNLSGLNLGGEISPAVGRLKGIVSIDLKSNGLSGQIPDEIGDCSSLKTLDLSFNSLDGDIPFSVSKLKHIESLILKNNQLIGVIPSTLSQLPNLKILDLAQNKLSGEIPRLIYWNEVLQYLGLRGNNLEGSISPDICQLTGLWYFDVKNNSLTGPIPETIGNCTSFQVLDLSYNKLSGSIPFNIGFLQVATLSLQGNMFTGPIPSVIGLMQALAVLDLSYNQLSGPIPSILGNLTYTEKLYMQGNKLTGPIPPELGNMSTLHYLELNDNQLSGFIPPEFGKLTGLFDLNLANNNFEGPIPDNISSCVNLNSFNAYGNRLNGTIPPSLHKLESMTYLNLSSNFLSGSIPIELSRINNLDTLDLSCNMITGPIPSTIGSLEHLLRLNLSNNGLVGFIPAEIGNLRSIMEIDMSNNHLGGLIPQELGMLQNLMLLNLKNNNITGDVSSLMNCFSLNILNVSYNNLAGVVPTDNNFSRFSPDSFLGNPGLCGYWLGSSCRSSGHQQKPLISKAAILGIAVGGLVILLMILVAVCRPHSPPVFKDVSVSKPVSNVPPKLVILHMNLSLLVYEDIMTMTENLSEKYIIGYGASSTVYKCVSKNRKPVAVKKLYAHYPQSFKEFETELETVGSIKHRNLVSLQGYSLSPVGNLLFYDYMENGSLWDVLHEGPTKKKKLDWETRLRIALGAAQGLAYLHHDCSPRIIHRDVKSKNILLDKDYEAHLTDFGIAKSLCVSKTHTSTYVMGTIGYIDPEYARTSRLNEKSDVYSYGIVLLELLTGKKPVDNECNLHHLILSKTANNAVMETVDPDIADTCKDLGEVKKVFQLALLCTKRQPSDRPTMHEVVRVLDCLVRPDPPPKSAQQLAMPQRPAVPSYINEYVSLRGTSVLSCANSSCTSDAELFLKFGEVISQNTE
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). Regulates the formation of oval xylem secondary cell-wall deposition pits through microtubule-dependent lateral inhibition of Rho GTPase domains, thus confining the area of active ROP domains within the lattice of the cortical microtubules. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular Localization:
Cell membrane. Cytoplasm, cytoskeleton. Note=Recruits calmodulin (CaM2) to microtubules. Associates with cortical microtubules and the plasma membrane to laterally restrict the localization of ROP GTPase domains.
Sequence:
MGKKGSWFSAIKRVFTPHSKEKQLSNNNQEPEIKSENKEKKKKGFGKKLRNGETNSFLPIFRQPSSIEKILSEAEREHNLVFRPPTPTDRANSSSTSVASPLVRPASPKVPSQRYVSSPKPISPRVAYPQVHYPKPPSPKPPSPRAVSPRIVQRREFVHRPEPSLLVKNAYAIKIQAAFRGYMARRSFRALKGLVRLQGVVRGHSVKRQTMNAMKYMQLLVRVQTQVQSRRIQMLENRARNDKDDTKLVSSRMSDDWDDSVLTKEEKDVRLHRKIDAMIKRERSMAYAYSHQLWKNSPKSAQDIRTSGFPLWWNWVDRQKNQNQPFRLTPTRPSLSPQPQSSNQNHFRLNNSFDTSTPNSSKSTFVTPSRPIHTPQPYSSSVSRYSRGGGRATQDSPFKDDDSLTSCPPFSAPSYMAPTVSAKAKLRANSNPKERMDRTPVSTNEKRRSSFPLGSFKWNKGSLFMSNNSNNKGPGSSSSGAVVLEKHKTLKSVGNLSIDSTVSMPATIGRRAFNRFA
The following text describes a protein:
Function:
Required to initiate and then maintain lateralized gene expression in the ASE sensory neurons. Involved in determining cell fate in the ASE neurons. Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.
Subcellular Localization:
Nucleus.
Sequence:
MGRGRGVAIQETIEECRDTISDRIQYNLGLNESKVVLMDIVTGPNQNVSLQERTKRWMAVSVDARMTKFKKNFYPTNQKNSKNISKDLDPPIQRVDAHIVTPVAGKCGMPLQKFPEFKHDHEKIKIERDAKYVDYSVDEFDMSWMSIMNAKRTKLGLEIFSVAIYEHWVDRLEKMCIWKPKEFHKLKDENGEELDDVCNICLDGDTSNCNQIVYCDRCNLSVHQDCYGIPFIPEGCLECRRCGISPAGRVNCVLCPSTTGAFKQVDQKRWVHVLCVIWVDETHFGNTIFMENVQNVEKALHDRRALSCLLCKNRQNARMGACIQCSETKCTASFHVTCARDSGLVMRINETEDGQVNRFVWCPKHAPPLTDADREMRQLMLRNARRENERKGPMISMPTLMKSMISTICVERPFSDYSEIIYFWYEKRLNRLGAPLLKNFTQGASKSRRLLPKSTICGQLKNVETCEMKKQVNAVKESLASGLEIFDMIVRREERKKDMLNSYIRMFERGFKPTELLCQEVIEALKTIDAGKVFAEPVELVGYTDIIENPICLKDMSEKAASGKYSTVAALSADVQLMLSNCATFNKGNRVYIKYGNTYRKDSTPILEIAEKEEVERLALKTDEKFMTQLLNGVMVEYNGWAQSRNEVAKEIPPPTPSRGRGTGRRRQNPFLDVQELDTDDSKDSSALSEIPGSSKKSSRKRGIQDTKMEEDEEIKPSTSGTNAVASVPLLSSSRESKNKSKSSDADVSSPKSSWLGSPSTSQNLRRRVQGFSGNESSPKVHKKLSTDNPSNSNLRQTTLTNFFGTNPKTQQQVTFADMTATPSGSGNKNVSQRSLFDTPSTSKASSFTSLSSTRPSTRSTSIIPTINKKNAFRMSSASIQSPLPTTKKIGVRAMATDDEEEDIVIQPPPKEMTTQELEAEKLKSAENEAMSKFAHNQLVIVDGRAAKVIESRLAHLASDIHHEQRQSMMKKRREVLSEIPQAAVIYVEFFQKSNTLENFQWVTPDKVELLDLNNIGQRSPKIPGLKAAKEWHQKVLNGEDV
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEEKKAESTNKNVKKANLLEHNSIKHILDESVSDIVKSRGYKEDVRLSNLKLILGTVIIVVALVAQFYNKKFPENRDFLIGCIASFFDYDKYVVLNGVLQLILYTKEKNAILFTYPPEGSFTSTGLVVSSKLPRFSDEYTLTIDSADPKSISAGKSVQLTKSVTQWFTKDGVLVEGLFWKDVEALIKDYAKEEPKKKK
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MNENTENSSAASLTASSTASTSMSEQRKKKLQELRSRMKQSTLENRKELIQEHQRMQANPDLEKRLERKKMEAEEALAKLETEERGEDYERRRAWDWTIEESEKWDQRLQRKRRNVENVAFADYHQQAQRDYQRMMRDLKPDVQSYKQSKQSKHENNQATPSNALVTEADEDAEDEWNWVHNKPDKARVDMLVEEMTRQEQQRMKNSKRRGRSDDDHITFINERNKKFNLKLKRFYDKYTKDIQDNLERGTAI
The following text describes a protein:
Function:
Essential protein required during embryogenesis. Mediates group II organellar RNA introns splicing (e.g. ycf3-2 and trnA). Binds weakly to specific RNA. Promotes the biogenesis of chloroplast thylakoid membranes.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Sequence:
MALSLSQTRPPSLSHSHTLSVIVPKRTFVSIRCGPRDNRGPLLKGRILSTEAIQSIQSLKRAHRTGVSLSLTLRPLRRLIKSDLISVLRELLRQDYCTLAVHVLSTLRTEYPPLDLVLYADIVNALTRNKEFDEIDRLIGEIDGIDQRSDDKALAKLIRAVVGAERRESVVRVYTLMRESGWGSESWEADEYVAEVLSKGLLRLGEPDLASQVSLKSSILKP