lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP.
Sequence:
MDGTNGAMACGGKGKVVVVIGATATGKSKLAVDLALRFGGEVVNSDKIQVHDGLAIVTNKVTAEECRGVPHHLIGVVSPDADYTAADFCRDATRAVGSIHARGRIPIIAGGSNRYLEALLDWEPAFRRRYECCFLWVDGDLPVLDRYIRGRVDCMLEQGLVDEVRGIFQPDADYSRGIRRAIGVPEMDKYFRLEAVGELDGDDDELRAQLLSVAVDEIKANTCGLVRRQLRKIRRLLGISRWSLRRLDATAVLMLKTSVARDPETERAAWEADVAGPATRAVATFLGRNGQTTDGKAGLVAAAAKEVAMAGAGTTEWCGQQLEKAAVVPGRARVFLGMKAAAAAV
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPKIKPRIYLYKAVQPVFLISKLAGLSTISFDEKSGYVKTQLGFVWSLFVFTLYISCIVFYLLNYKVTTGEKQWILHAIGRLNTNIRIITLVVLSLVMIKSGQKIVTIFTQIKKIDKKFETSNINLEYSPRFRSTIKFAVFCQMIHYILYMILQWKYLPKTTSFTYIIATTGATLNSGIVVHQFVVVLSLLKQRFQGFNQSFSQQITKNYHRHEQKSILVRLNSYYKLHKKLCNLTMMVEKTYATANLIILLKCLVSLTTAIHFVMDTHFIHPIKEKILIDQVKYLASISTNIFYILTLTLFCSKTAQEANKLAALQLQFPIKSNLIGLRVNIKIKILLNWGEFQIRNFILQSKHEKVAITCFNIVAAIATSSIIIIQFGTTKSNTP
The following text describes a protein:
Function:
Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embryonic viability.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, cilium, flagellum. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody. Accumulates in the nucleus of newly divided cells in a diffuse staining pattern, thereby restarting the cycle. Localizes to ring canal structures at the growing end of elongating spermatid cysts.
Sequence:
MDPFTQHMLEKAEQRSRALGISNASKFPLVECSVPSSSATSASGGDAGVLAPRSRSPGGQSAASGGGKVVTLGKATLEASPAKPLRHYTAVNKENLDMGIEINITTDKPIGVQVEIQEQEVTDDEEQAEGGALNPLLEAEPVNQPLARLRDTSRSRLQRMGALYSNTDDLSSPIHRTEGQFHVTTGEEEDCGNRSSRQPKQRLGKLAALADTINQWEDDTSHHEVHRLLEAPPPKPHLSSRRAEKGPAPLPPKKDEVDEASRTKQLKWDPKVLSSLEAQGFQRRESSTIKHTYDYAKQEEAAPASKVEDAVLTAKPPVPQKSTTVSQVAKNFASSAPAPKPAPAPAVSVKSGLVSGRAALFENKGTGGQSQGLRNQKDPCELSLKERMKLFETGNNKAMLPMAPIGSAPSITQIRAEEVKQHLAAMHPVTAAAATTVVAATKPKQENKLRDKVAALVANAQSSAETRIKDIDRQRQEDMQIISNRFNKQKELFDNQPSDSSVAAQARPPAPAPSRVVRPMPPPPPPPIAALSPGLASSKRRSPGDAPTTDEDSKRARKSHSDRLYPALSDLDSSGDNCCAAETASATDDSHQQDEEETESCMDESDDQSQTEDSSAGMCNGSLGREIMSAVQRNEVEMQQQQTGKKTVRYADQDMYYDDSSLNSSQVSAGIDDYLDEALVEDYGSTQDDQSDSGDEQNASRLSLGSKGTTASNSFSFRKNPASICTPIEEHHEMEMDLQTPLLSGAQPVKSELSVNQDNDNLVTLVHTVSFYRRQQSANSSNSTPVRKICREQQVMRSALAGDCHAKHRLEYDSPQQSDYVAAATDIADQTDEDDEEMQNAREVNDASQAQDKIKKLLSEVCKQQQVIGQASQALNLCAATVEFSGSTESVEGERYLLLATHRRQACLDEVQRLRVENSIRPVGAPKEKGLLTVKDITIPLRQEYVRKMASNNINGHHLVCLLKYNEHVLATKTVPTMPGLLSVKFPDVLQLNNVYADFRITLEIYGMLAQRDQLPHELKYHINLNKKGGIKTPKKKGGENRLVMPPVQSPAGPHVVRTPQLVQYGFAIFSLREIQRTTWTLTQVLGVSPLEGVVHMKVNCELSVSVEYKGFLTMFEDISGFGAWHRRWCYLNGSVINYWKYPDDEKRKTPMGSIDLNSCTSQKVTTAPRDICARLNTMLLECERPALETDQESLIIVPNGRTTTVRHLLSADTKEEREEWCAYLNKALTLLRAWGTTH
The following text describes a protein:
Function:
Forms channels functionally larger than those of classical porins; May act as a regulator of the RCS-phosphorelay signal transduction pathway.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKLLPCTALVMCAGMACAQAEERNDWHFNIGAMYEIENVEGYGEDMDGLAEPSVYFNAANGPWRIALAYYQEGPVDYSAGKRGTWFDRPELEVHYQFLENDDFSFGLTGGFRNYGYHYVDEPGKDTANMQRWKIAPDWDVKLTDDLRFNGWLSMYKFANDLNTTGYADTRVETETGLQYTFNETVALRVNYYLERGFNMDDSRNNGEFSTQEIRAYLPLTLGNHSVTPYTRIGLDRWSNWDWQDDIEREGHDFNRVGLFYGYDFQNGLSVSLEYAFEWQDHDEGDSDKFHYAGVGVNYSF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNGSMGAAGGQVENERAAEVPVSTLEMRTLSPETFLYTEVARSHLGERAGRVIELLLNKGRLSVSELVHLAPELGSKSVRTVLVSLIQLRCVQYLEETTVSGRKITYYYFNEDGFQLMLYAGDIVAAVESQFEADDAKEIAAQIVQNVLALGSLTTKDYMQSLASDVSVNDVASMFVKLVELGFLVPLSNVHYMPLADLWDVLYKKEYNAIPKNSTLSDAKKRAETKAKTKVQFNTLLKNVEMSNVLMTDMQTSMRRVQDNLPLTFNFGRYMKHRRSRQLVQFARSRVGSVPAMIYKVALKITEQCARALSDPLCETGLMQELEEQLAIQEDMALDDEKLPGVTFNAVDISRNLPNNIDLRGTLTSMQRRSQERSTHQGQSHKRLKAEDGMAVAVNHLATVEEEAEGDELLHGSDDDMDMFFDEGDSDPKSVSLINGHLKLLSTGSVPFLIESRPGLFYVPYSKLMPILKEAVYDAIIASTLGPSAHRILRCVRDNSLVSEKVINNTALMREKDIRSVIATLVKYNAVDILEVPRTADRAASRAVFLFKINEKHAYDFMKQNLAWNIANSIHKTEILKEENFTLLSKAQRDDVKGREAELLLPSELNQLKMVNERELNGHARKIRLLSMWEVFKML
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MANEEVIAVKDAIHKLQLCLLEGIKDENQLFAAGSLLSRRDYQDVVTERTIANMCGYPLCSNCLPSERPKKGHYRISLKEHKVYDLHEAYMYCSTNCVVNSGAFARSLQDERSDTLNTAKLNEVLKLFVGLHLHSTEDVKDNGELGLSKLKIQEKLDVKGGEVSMDEWMGPSDAIEGYFPQRDQSVKPALLNNIKKGFKNKQTKLQNKKNMILNEMDFSSTIITQDGYSISKLPAPINVVSSKKVNEAQTKTSYEVGDADVSILGKQVDVLQLYSGEETEKTDSNDRSYKVDKFNNREVSSGPCQHDVRNKSLEVLNMSDAGREYASDGAREKQSLRSSLKSSNYKKMARSVTWADENIDNGTGKKMECSAEISEEANQAYMGSGPTDMEEDDDSYRFKSAEACAAALKQAAEAVASGSDVPDAVSHAGIIILPPPQEVDEAILQENDEVLDTEPAPLKWPRKPGVPNYDVFESEDSWYDSPPEGFNLNLSPFATMFNSLFTWISSSSLSFIYGNDESSNEEYLSINGREYPRKIVLSDGRSTEIKQTLARCLARALPGLVADLRLPVPISVLEQGLVLLIDTMSFVDPLPAFRMKQWQLIVLLFLDALSICRIPVLTPYMTGRRTLLPKVLDGAHISAAEYEVMKDLVIPLGRVPQFSMQSGG
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway. May cleave double-stranded RNA to produce short 21-24 nucleotides (nt) RNAs which target the selective destruction of complementary RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAMADDDDGPLPPPPPPPPPRRPHRQLQPRRYQVEVFEAALQGNTIAVLDTGSGKTMVAVLLARHHVGRVRAGEVPRRIVFFLAPTVHLVHQQFEVIREYTDLDAAECYGASGVGDWSTDRWNKEVGSKEIAVMTPQILLDALRHAFVTMSAVSLLIFDECHRACGNHPYTRIMKEFYLGSQWRPAVFGMTASPVATKGTCTVQDCEAHIGQLELTLDAKVYIIKDRSELESFSPPATIVHEYYDAYSIDFEDLKSKLQILYEEYDALLASLQESSPNKFEDTNNILETSRKTLFRYHEKIFYGLNYLGPIITAEVVKIYNESIKTLGDSEDCLFSKASFSLHVAYFKEALDLIEEVLPHGYGELMKSESGSAELIKRGYISSKVDALINIFKSFGSSNEVLCLIFVDRIMTAKAVERFMRGIVSFSSFSISYLTGGSTSKDSLSPAVQRYTLDLFRSGKVNLLFTTDVTEEGIDVPNCSCVIRFDLPRTVCSYVQSRGRARRSSSNYVLMIERGNMDQQEHIFRIIRTEYYIKHFALYRHKNPNVSSSEWPMQDKYAYYVDSTGATITADCCVDLIRKYCEKLPKDRYYMPKPSFAVAIEDGSYQCTLTLPPNAAFQRIVGPLCSTSNLAKQLVSLDACKKLHQLGELNDHLLPFTEEPIEIDVALRDGKFLSGPGTTKRKELHGTRNVLALSGSWIHESESVTLNAYRFDFLCDQEGENYAGFVLLMESALDDDVACSKMDLFLIPNKMVYTTVTPCGKVQLDKKQLRDGKLFQEFFFNGIFGRLFHGSRTSGVQREFLFRKGHEIQWSSESMYLLLPLRHSPHIQQDLNIYWEAVESCTQAVEQLRNLYLEDENIRANFIQHRSIKEKDIIHLANKSLHFSSIKDSVVLSLHTGRIYSVLDLIYDTTAEDSFEEMYNGKASPFSSFMDYYREKYGIVIQHPKQPLLLLKQSHNAHNLLFSKSKYIDGSTGDPLLMEKEQIHARVPPELLIHIDVTIEVLKSFYLLPSVMHRLQSLMLASQLRRDIGYTQHIPSYLILEAITTLRCCETFSLERLELLGDSVLKYVIGCDLFLRYPMKHEGHLSDMRSNAVCNATLHKHGIWRSLQGYVRDSAFDPRRWVAPGQISLRPFPCNCGIETAFVPTNGRYISDDPSFVVGKPCDRAHRWMCSKAISDCVEALVGAYYVGGGIVAALWVMKWFGIEIKCDRKLVQEVKLNASYICYLPKISVIEELEAKLKYNFSVKGLLLEAITHPSLQELGVDYCYQRLEFLGDSVLDLLITRYLYVTHTDVDPGELTDLRSALVSNENFAEVVLRNNIHSHLQHGSGILLEQITEYVRSNLECQGKVNKFLQHATCKVPKVLGDIMESIAGAIFVDTDFNVDVVWKIVEPLLSPMITPDNLALPPYRELLELCSHLGYFINSKCSSKGEEVSIEMSVQLRDELLIAQGQDRNKKSAKAKAAARILADLKKRGLSMKQCPSKAKQSGIISSDQQYPLASLESPLDYCQVNVNPSLGGLPSLKEAVVLRLKMDKGGPRSALFKLCKRLQWPMPEFEFVEQRFRTPIVLDGVTTTNFNSFVSTITLHIPDVAAITLQGERRTDKKSSQDSASLTMLHKLQELKVCICKT
The following text describes a protein:
Function:
Involved in both the histidine and tryptophan biosynthetic pathways.
Subcellular Localization:
Cytoplasm.
Sequence:
MPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQALAAVRD
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.
Sequence:
MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSDDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLEPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETAEEELEEIASENSDSIYSSTPEVKA
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MEQATTLFILLSTLLLAVSVESPQPPLFPDEALPTKSGYLPVKPAPGSSMFYAFYEAQEPTTPLPDTPLLVWLQGGPGCSSMIGNFYELGPWRVVSRATDLERNPGAWNRLFGLLFVDNPIGVGFSIAASQQDIPTNQRQVAEHLYAALVEFLEQNPSFENRPVYFTGESYAGKYVPAIGYYILKEKPNGKVNLKGLAIGNGLTDPVTQVQTHAVNVYYSGLVNAKQRVELQKAQEISVALVKSQKWREAADARTELLTLLSNMTGLATLYNTARAIPYRTDLVVDLLNQREAKRVLGVSETVRFEECSDEVEDVLRADVMKSVKFMVEYALERTQVLLYQGMLDLRDGVVSTEEWMKTMNWSGLGMFSTAERRVWKDEDGVVAGYVQRWGNLCHVAVTGAGHFVPTDKAVNSRDMIEGWVLGKGLFGGKDVKQTTSSSLYHSI
The following text describes a protein:
Function:
Required for protein transport from the endoplasmic reticulum to the Golgi apparatus.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus.
Sequence:
MSTLKSIARSATVAFAPTASIMAVGTMAGAIDPSFSSSASLEILQLDFANTEEELPVIASCPTAERFNRISWGNNAVASEEYALGIIAGSLVDGTITLWNPAKLTSEDGGSPEESVIASWRKHEGTVRGLELSVLAPNLLASGGDDGDIYIWDLKVPTNPTHTPNLNNASPRGEISYLSWNRKVQPILASTSSSGTSVVWDLRKAKPVLSFTDPDIRRRCSTLQWNPENATQLIVASDDDRSPSLQVWDLRNSVSPLKELVGHSKGVLAMAWCPIDSSLLLTCAKDNLTLCWDTFTGEILCELPARTNWNFDVQWSPRTPGVLSTSSFDGNIGIYNIEACSQTPSNVTSFGHTIKGTNSSYAKKAPKWLKRPVGVSFGFGGKLITFGPSKKTVPGGFGTSSEIRLHSLVTEEDLVKQSTQFETAIADGDKPAMRQFCDLKAETARSDDDQQTWKFLKVMLEDDARKKLLAHLNFDVQPTENDDDRRPEQKPDGSEDTIPVDSESPEGDCEPSPSPVDEDVQQASEAGEDDFFDNIHTPKKSDGVPTGGLSDLTLDSDRIEVDSSQSPATEGGDVDHLIESEEAIQRALVVGDFALAVKHCMTANRMADALIIARLGEATLWEKTQNAYIRKTGRSYLKIMSAIVNHDLKGLVETRPLMAWKETLALLCTYAPFEDWTQLSDALAARLDAAGEIQAATLCYICSGNIEKVAEIWSRSLETVNGGKVFVDSLQTLMEKVVILSLATGQKFISASLARLVKIYAELLVSQGLLVTAMEYLSLVPADQSSLELSILQDRIYGSGKVSDAKAEAPTIPWERQPLQFEAPAATEPLQNNYPSASSNVSRDYQAFATPPSFQPQQQPAYGGMTANHAGYYPSPTLQPTQAPFVPTPVNPPSVSQVKGFVPMAPPAIPNVEQYQPTGQNQYYTGSSNAQSFTPSQFSQPSFTPAPPSGNYTQVPQPMTFTPLSQPPFSAVAQTPSFAPAQLPNMMLPGPAQPVTAPPAVQGFMPASPRTQPLSSSGIVPGSQVQSPQTTSSPSPAVALTPPPTVQTVDTSSVSAELKPVVATLTRLFHETSEASGGARANPAKRREMENNSRRLGALFAKLNTADISANASLKLIQLCQALDARDYSSALQIQVGLTTSDYDECGFWLPTLKQMIKTRQSLMR
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAGAGSDSVALPRPHASILPLMSVLGSLLTCLLVTVNRAVPDPYMDEVFHAPQAHKYCQRRFDEWDPKITTFPGLYLVSTLYSEAAARLGWEFCSLSVLRSVNVLFALGNMALCVLLRRHVAPLDPNAWLHGLRVAVFPPLFFFAFLFYTDGGATFFVLLMLWLAERVDLLQYPPARGSFLLSAVSGVVAVLFRQTNIVWVFFVAGTVVVRCVELAHSKFIYGSSKKDSNTSGTDAVTHRVFLNFVGVIVSNLPSILQIVWPFVVIVAGFLGFIVKNGGIVVGDKSNHEVTFHGAQVLYFIVVAATGFGLSLIAPSQLQRTKTLSAVETGLRTCRVFGPYSITARRQSAFHLWVVIAVYMAVNALTLYVFLYRPFEWVDGSTARFMW
The following text describes a protein:
Function:
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
Subcellular Localization:
Secreted.
Sequence:
MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Modulates outer kinetochore KMN network activity by regulating interactions within the network.
Miscellaneous:
MISCELLANEOUS: Present with 1300 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Enriched at the kinetochore in anaphase.
Sequence:
MSTPRKAAGNNENTEVSEIRTPFRERALEEQRLKDEVLIRNTPGYRKLLSASTKSHDILNKDPNEVRSFLQDLSQVLARKSQGNDTTTNKTQARNLIDELAYEESQPEENELLRSRSEKLTDNNIGNETQPDYTSLSQTVFAKLQERDKGLKSRKIDPIIIQDVPTTGHEDELTVHSPDKANSISMEVLRTSPSIGMDQVDEPPVRDPVPISITQQEEPLSEDLPSDDKEETEEAENEDYSFENTSDENLDDIGNDPIRLNVPAVRRSSIKPLQIMDLKHLTRQFLNENRIILPKQTWSTIQEESLNIMDFLKQKIGTLQKQELVDSFIDMGIINNVDDMFELAHELLPLELQSRIESYLF
The following text describes a protein:
Function:
Involved in recombination DNA repair and in the repair of gamma-ray-induced damage.
Subcellular Localization:
Nucleus.
Sequence:
MDISNYVDNFYFDEKIASAFELGEVSTVDLLTLDITELERRTHCSQSELLQLIEQISLLLQPVRCSASKVTSKYLTTGDVKLDETLHGGIPVGQLTEICGESGSGKSQFCMQLCLMVQLPLSLGGMNKAAVFISTESGLETKRLFELARYLPERYPKADKKDIIIKNPGDRVYTILCPDLESQEHIIQYQLPILFNRDKIGLVILDSVASNYRAELRYNRSKSHFRDLDNIAKRGNQLGKLAMTLRTLAHQHEAAVVIANQVSDRIPRDYDAIGLFSLDYQSQWFSGWDDTDPNPKIPSLGLVWTNNISTRLALIKKTDSATNNSGRIFRVVYSPNSPRLDVRICIGSVGIYSC
The following text describes a protein:
Function:
Bifunctional enzyme that has both L-aspartate decarboxylase and transaminase activity. Has high activity with L-aspartate, and much lower activity with D-aspartate, L-lysine and L-glutamine.
Sequence:
MSKDYRSLANLSPFELKDELIKVASGKANRLMLNAGRGNPNFLATTPRRAFFRLGLFAAAESELSYSYMTVGVGGLAKLDGIEGRFERFIAEHRDQEGVKFLGKSLSYVRDQLGLDPAAFLHEMVDGILGCNYPVPPRMLTVSEQIVRQYIVREMAGGAVPPESVDLFAVEGGTAAMAYIFESLRISGLLKAGDKVAIGMPVFTPYIEIPELAQYDLKEVPIHADPDNGWQYSDAELDKLKDPDVKIFFCVNPSNPPSVKMDQRSLDRVRAIVAEQRPDLLILTDDVYGTFADEFQSLFSVCPRNTLLVYSFSKYFGATGWRLGVIAAHKDNVFDHALSQLPESAKKALDHRYRSLLPDVRSLKFIDRLVADSRVVALNHTAGLSTPQQVQMVLFSLFALMDEADAYKQALKQLIRRREATLYRELGMPPLENPNSVNYYTLIDLQNVTCRLYGEAFSQWAVQQSSTGDMLFRVADETGIVLLPGRGFGSDRPSGRASLANLNEYEYAAIGRALRRLADELYEQYKALGKE
The following text describes a protein:
Function:
AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression. In addition to flagella genes, also regulates expression of biofilm-related genes. Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present.
Domain:
The N-terminal FleQ domain mediates dimerization and is essential for function.
Sequence:
MWRETKLLLIDDNLDRSRDLAVILNFLGEDQLTCNSEDWREVAAGLSNSREALCVLLGSVESKGGAVELLKQLASWDEYLPILLIGEPAPADWPEELRRRVLASLEMPPSYNKLLDSLHRAQVYREMYDQARERGRSREPNLFRSLVGTSRAIQQVRQMMQQVADTDASVLILGESGTGKEVVARNLHYHSKRREGPFVPVNCGAIPAELLESELFGHEKGAFTGAITSRAGRFELANGGTLFLDEIGDMPLPMQVKLLRVLQERTFERVGSNKTQNVDVRIIAATHKNLEKMIEDGTFREDLYYRLNVFPIEMAPLRERVEDIALLLNELISRMEHEKRGSIRFNSAAIMSLCRHDWPGNVRELANLVERLAIMHPYGVIGVGELPKKFRHVDDEDEQLASSLREELEERAAINAGLPGMDAPAMLPAEGLDLKDYLANLEQGLIQQALDDAGGVVARAAERLRIRRTTLVEKMRKYGMSRRDDDLSDD
The following text describes a protein:
Function:
Plays an essential role in motile ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Localizes to centrioles and basal bodies.
Sequence:
MEEIPVKVAVRIRPLLCKEALHNHQVCVRVIPNSQQVIIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHIASVVEGQKGIIPRAIQEIFQSISEHPSIDFNVKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECHVESAGEVMSLLEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHIVSKFHFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAGVSQTTQINREGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEKQQHKLQEWFNMIQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKRELKKCQCVLAADEVVFNQKELEVKELKNQVQMMVQENKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEELTKLNLSVTSSAKENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQDSRKVHTSPPMYSLDRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQDETQKSDLENEDLKIDCLQESQELNLQKLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHMKYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEIQLKTGQEEGLKPKAEDLDACNLKRRKGSFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQEKSHLENKKLRSSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQVEVLQKEKDQLQKRRHNVDEKLKNGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQNRQKSLRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFNKVVNLREAERKQQLYNEEMKMKVLERDNMVRELESALDHLKLQCDRRLTLQQKEHEQKMQLLLHHFKEQDGEGIMETFKTYEDKIQQLEKDLYFYKKTSRDHKKKLKELVGEAIRRQLAPSEYQEAGDGVLKPEGGGMLSEELKWASRPESMKLSGREREMDSSASSLRTQPNPQKLWEDIPELPPIHSSLAPPSGHMLGNENKTETDDNQFTKSHSRLSSQIQVVGNVGRLHGVTPVKLCRKELRQISALELSLRRSSLGVGIGSMAADSIEVSRKPRDLKT
The following text describes a protein:
Function:
Required for meiotic chromosome synapsis and cell cycle progression. May act as a molecular zipper to bring homologous chromosomes in close apposition. ZIP1 may encode the transverse filaments of the synaptonemal complex.
Miscellaneous:
MISCELLANEOUS: Present with 391 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome. Note=Synapsed meiotic chromosomes.
Sequence:
MSNFFRDSSMGFKPRPNIFAKLRVRDVDSDSSANTVVENSSNCLDVGSSIEGDDTFKKPHKTSTEQELITSMSLSQRNHGYSDDMEIGSPKKTTSTDQYNRILKNDVAAIENDTDEDFEITEVREVSEGVAKETKESHGDPNDSETTLKDSKMHEYTMTNGKAPLHTSINNSSTSSNDVLLEAFTNTQRICSNLKQELQKQQQDNAKLKVRLQSYASNSDKINEKVGKYKSCLETLQERIATLTSHKNNQETKLKDLRQNHQLYQRRISGFKTSIENLNKTINDLGKNKKEADAELMKKGKEIEYLKRELDDCSGQLSEEKIKNSSLIQEMGKNREEMIKSIENFFSEDKAHHLLQFNKFEERVHDLFEKKLQKHFDVAKDTLNVGLRNTTVELSSNTETMLKQQYEDIKENLEQKMSSSKDEMAKTINELSVTQKGLIMGVQEELLTSSGNIQTALVSEMNNTRQELLDDASQTAKNYASLENLVKAYKAEIVQSNEYEERIKHLESERSTLSSQKNQIISSLGTKEAQYEDLVKKLEAKNIEISQISGKEQSLTEKNENLSNELKKVQDQLEKLNNLNITTKSNYENKISSQNEIVKALVSENDTLKQRIQQLVEIKENEQKDHTTKLEAFQKNNEQLQKLNVEVVQLKAHELELEEQNRHLKNCLEKKETGVEESLSDVKTLKQQVIVLKSEKQDITAEKLELQDNLESLEEVTKNLQQKVQSQKRELEQKIKELEEIKNHKRNEPSKKGTQNFTKPSDSPKKNATTSNLFPNNSAAIHSPMKKCPKVDHISKSRINSSKETSKFNDEFDLSSSSNDDLELTNPSPIQIKPVRGKIKKGSNCMKPPISSRKKLLLVEDEDQSLKISKKRRRK
The following text describes a protein:
Function:
Stimulates the ATPase activity of several Hsp70-type chaperones. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (By similarity).
Domain:
The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.
Sequence:
MTNSSNNSNKCENKNYYEILKVSIDADIEEIKKSYRKLALLYHPDKLNKEENIEENINNFSNCLVNNNNNNNNSNTKDFNDIQIAWETLKDDLLRKQYDSLLLEQKRQKYSVSDEIDLDDMEFIEENSEYVYPCRCGDHYIITEDQLSEGSDVVCCSGCSLSIKVIYQME
The following text describes a protein:
Function:
Plays a role in viral egress via lysosomal trafficking. Forms homotetrameric ion channels (viroporins) localized at endosomes and lysosomes, that may induce deacidification of lysosomes, allowing safe egress of virions via lysosomal trafficking. Also blocks autolysosome formation by binding and sequestering the host component VPS39 for homotypic fusion and protein sorting (HOPS) on late endosomes. This prevents fusion of autophagosomes with lysosomes, disrupting autophagy and facilitating virus egress. Induces host RETREG1/FAM134B-dependent reticulophagy by interacting with host HMGB1 and enhancing the association between HMGB1 and host BECN1. This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection.
Subcellular Localization:
Virion. Host cell membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Secreted. Host cytoplasm. Host endosome. Host lysosome. Note=The cell surface expressed protein can undergo endocytosis. The protein is secreted in association with membranous structures.
Domain:
The second or the third transmembrane region are responsible for Golgi localization.
Sequence:
MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL
The following text describes a protein:
Function:
Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTELGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRFGSDSPESYGLGKAEELFGEEISEEDKETEENEMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACVALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAIGCICLMAMVAVMEERKIRREKKIQQVNIA
The following text describes a protein:
Function:
Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus.
Sequence:
MEADTSVNMFSKVLENQLLQTTKLVEEQLDSEIQKLDQMDEDDLERLKEKRLEALKKAQQQKQEWLSKGHGEYREIPSERDFFQEVKESKKVVCHFYRDSTFRCKIVDKHLALLSKKHLETKFLKLNVEKAPFLCERLRIKVIPTLALVKDGKTQDYVVGFTDLGNTDDFTTETLEWRLGCSDILNYSGNLMEPPFQSQKKFGTNFTKLEKKTIRGKKYDSDSEDD
The following text describes a protein:
Function:
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Sequence:
MTIAYVGVGANLDNPLKQVQIAVSNLSTLPQTACLGYSSFYRSKPLGPTDQPDYINAVAAVETTLSPQMLLKALQRLEEKQGRCRGGKRWGPRIIDLDILLYGDLALQSDELCLPHPGLFVREFVLYPLAEVAEDLILPGGESILELKAKCPDRGIERIIKNPSSLLPFPFRGKGLEKEGDTKALA