lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine and threonine phosphatase. Dephosphorylates phosphoglycerate kinase pgk1 at least on 'Ser-203' to negatively regulate targeting of pgk1 to the mitochondrion, thereby negatively regulating production of acetyl-CoA and consequently aflatoxin biosynthesis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nuclear following DNA damage.
Sequence:
MFSGSSSPPKDKSNSVPHSGAVDTQSLSVHPEEGSAAQTSKSLPSGGFFTRRTSEDQAPAGEKKRRSSTVTKAATFFTNAKNSLSLSSSPRESSSFNYTVRSPQTLQSLGSMDPALSVPQGSLNNSAGDSLPTPRSSFKVGVTEDRNRKCRRTMEDTHAYLYNFLGTPAPLARADGENEAGSSLAPDEASSVVETDNGYFAIFDGHAGTFAAEWCGKKLHLILEDIMKKNPNTPVPELLDQTFTTVDQQLEKLPVKNSGCTAVIALLRWEDRIPSSHSATGSSALAPAAAAAAAAKGDSNSEADDTPTQATSSGPSILPKLQEKAIRQRVLYTANVGDARIILCRNGKALRLSYDHKGSDENEGKRIANAGGLILNNRVNGVLAVTRALGDAYLKDLVTGHPYTTETVVQPDSDEFIILACDGLWDVCTDQEAVDLVRNVPDAQEASKILVDYALARFSTDNLSCMVIRLDTNRVKEVINKTAEPIGVAGDPSMDVEHGVSEADKIIEGARKSMANADIADDGETAEKGKNDILHKMVDGEPGPEMSLDDSNDAPTVSHLNKTNANNGIP
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MIETEKKEERVLLIGVELQGMDSFDLSMEELASLAKTAGAVVVDSYRQKREKYDSKTFVGSGKLEEIALMVDAEEITTVIVNNRLTPRQNVNLEEVLGVKVIDRMQLILDIFAMRARSHEGKLQVHLAQLKYLLPRLVGQGIMLSRQAGGIGSRGPGESQLELNRRSVRNQITDIERQLKVVEKNRATVREKRLESSTFKIGLIGYTNAGKSTIMNILTSKTQYEADELFATLDATTKSIHLGGNLQVTLTDTVGFIQDLPTELVSSFKSTLEESKHVDLLVHVIDASNPYHEEHEKTVLSIMKDLDMEDIPHLTLYNKADLVEDFTPTQTPYTLISAKSEDSRENLQALLLDKIKEIFEAFTLRVPFSKSYKIHDLESVAILEERDYQEDGEVITGYISEKNKWRLEEFYD
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell division.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Sequence:
MQKKSTISWSYDAWIVICTLSLLALGLLMVASASMVISDRQFGYPFHYFIRHLIYLSLGLTLAWVASRVPIKVWKTYSGYLFLVGFLLLILVLAPVIGKTVNGSRRWIQLGFISLQVSEVVKFVTILYLASFLQRYQSEVQKELKGFLKPMLLVGILSGLLLLEPDFGAAVVITMTCLALLFLAGVRLWPFCVLLVLVAGSLILLAILSPYRLQRLTSFLNPWAHQFGSGYQLTQSLIAFGRGGLFGVGLGNSVQKLFYLPEAHTDFLFAVLAEELGLIGEILLMGLFVLLIGRIILIGRRAENSNQLYSAYLAYGIALWLGLQVIINIGVTAGVLPTKGLTLPFISYGGSSLLMNCLAIGVILRIAYETEN
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSQDSAALEEFGNQFVKWYYNKFNQVKEDIIPLYRPESLVTFQENMITGLMPNGRLSIEDKILSESLKYMMKSPTTWTIQPSISNTVLICVQGTCKMTPEEAEELGFFENFIIGMEEGNFVILNQIFSTSSV
The following text describes a protein:
Function:
Affects motility and biofilm formation, and is linked to the regulation of sulfate uptake and assimilation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRIGNKILVFIVGFCLPAVVLVSYCLGVWFDHRVELLRQDNVRHELANIQQQFRIDVDRLGFLTNIYASPLSHLDSEQLKSLESSWLESSMSGNLSWFILRDGNLQNVFQNEQPIAEANRQEIAKAITTQAKPEFASAYLIGDKGYVVTAVASHLGEYVLLVRQLTERDLLEYAQTSLVARVSMSNVVTAHHSSHSSSVALPSLISQQPIYLHVEFSDDPFRDVKLSLDWVSLAVILLGILIVALGYVWLRACLLQPFKSLMQQLALVDPMASVYRPVTSEGNEELSVLANRVNSLLARIYQQKERGKITLESIAEAVILTDIEAKVIYMNPKAETLLEVASSNAVGESLASLLKAGEQLNQAVFHCIRLGETMPQVAKIKLLTTMPRIIERSISNVLNHEKEIVGTVVVLRDITQEELLKHQLQKRANFDGITGLLNRQAFEEQLPEFASQARSLAVCYLDLEQFKLINDSCGHTAGDRMLAMVARAIQSCLGPQELLARIGGDEFGLVICDRTALAVAQLLKQIIAQVSLQVLHDKNCNYKVGLSIGVAFGRAPYINAQELLKDADIACIAAKAKGTNQIHIYDDKDKELTYQRNAPKWAVRIAQAIEENELLLYYQPIRGLGASSKRQRMEVLLRIQEPCGRILAPAQFIAAAERFKLMPEIDKEVIRKAFLWLSLNSQLWQDHCISINLSGNSLGAEGMVEYIAKQQQIFDIPSQCVCFEITETTAIQNRHRGMEMLRQLRKLGFSFALDDFGSGFASYGYLRELPVDYVKIDGCFVKNLAVNAKDYAIVKSIQDVCRVMGIETVAEFVENQEIIDRLQTIGINYAQGYAIGRPQPLASYCEQFETRLAQRA
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Sequence:
MDRSIEAAVQLANKEFIKGFIAGQIILCILFFFLLKVFLFRNSDETSQEIVRRMHQRIAVSKPKPVSAQQRRTIDSLILGKIGYNTSQHPFESCNWLNILIAQFLLTLRTDAEFGLKSVSMLDSILNSAWKPSFLGDISITNFSLGEEYPTLKNARVRFAEPESGMKIHVDFSFDDQLTLGIDTQMLINYPKPGMAALPISIVLSIVKFSGTFVIEFVSKPILPVCQQPLYKSQASETSTSDLGHHTYVSVSVLDDFLLDFDVRSLLGHRTKVKDLPKLTSLISNSLRSVFISEMVFPACKMIKIPNGEELFGDIANAVDENSHDVFLNQENGSETLKSA
The following text describes a protein:
Function:
Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney. Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate. Transport is independent of sodium, chloride ion, and ATP. Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (By similarity). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (By similarity). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (By similarity). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity).
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney.
Sequence:
MKSAKGIENLAFVPSSPDILRRLSASPSQVEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSDFEEGPYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISISTIEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYVDVAMGESTDITEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADAKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFKMTCKNTMKFALFTSGVALTLSFVFIYAKCGNEPFAGVSESYNGTGELGNLIAPCNANCNCLRSYYYPVCGDGVQYFSPCFAGCSNSVAHRKPKVYYNCSCIERKTETTSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACRIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDLSFHKENAVVTNVLAEQDLNKIVKEG
The following text describes a protein:
Function:
Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.
Subcellular Localization:
Mitochondrion membrane; Peripheral membrane protein.
Sequence:
SVKVAVRVRPFNSREKERNAKLIVEMAGPQTSLIDPENTKPKRFTFDYSYWSHDGFIEDDNGVLVGTGPKYASQRAVFDDLGQGVLNNAFEGYNCSLFAYGQTGSGKSYSMVGYGPNKGIVPITCDELFKAIEADKGDTKYEVTFSMLEIYNEQVRDLLIRNNPKGGLKVRENPKLGLFYVVDLKKTAVGSYEEIERRTAEGTANRTVAATNMNATSSRAHTVVTITFDQIKKNDAGEETKKSSVINLVDLAGSERADSTGATGDRLKEGAQINKSLSALGNVISALAELSTSKKKIKVPYRDSVLTKLLQNALGGNSKTVMIAALSPADINFDETLGTLRYADRAKKIKNKATVNENPMEKLIRELKEENEKLKRAMEGGMIPSEGGAAIDPGGKIIEEIKAQLLANMDAMKEMSTSWDDKLKESQQNYSEKTSQKENAAMRRKTEPHLTNLNEDPQLSGVIVHFIKSGIYNTNQFTVYCRLFGFSVQKQHSIMTLENDQVSIKPGVPGAKTKINGAPLTGERVLQHFDRVLFGSNNLFVFNNPKNPVLPDGTPDKIDYEFAQKELAASKGFSTGGQGLSKEQQIAQEQVLELLPLVSEVNAVSEELDKHRSFEVILISGAAMEGISSNKTTKVMVKMKDLLNGNTWVWERGKFMNRRYLMQDLYQRHLDGDEDVKKIPNEEDPFWEPPEDVLIGTASIFLQSLAYGLDFDDRLTITDYKGAEEGFISVSCTPCLANGKPLGDDYFVEEPGDLLGKPYHFKVTIRNAEIHKARFSKGLTVKYRCYNEETLTQTETKSGTLSPEYNHTRIVTLATITQDHLDWFDQGCVTLQMFGRQEDSVADPRLLKMSTKVNYNYDIRCSLQNFNSNGYST
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MVKFLPSLCTSIELNDVQSQLQKIMEKQNFITTWDPETMLPPHTDVILEANDGRLVHAHKSTLMGKSTAFKTLFSATRDVVNPQTVKMDMDHASLEAFIHFFYTGFVKDDLMDSFADKLLRASDTYGISLLHNLCQEKMMTNIHPERIFQYFLLGSKCHAEQLVHAIISFVANNYSDIAEINGYDDFLKDDPTLVAKLGNGIVKKLQAKLKNHPKIM
The following text describes a protein:
Function:
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
Miscellaneous:
MISCELLANEOUS: 'Zizim' means 'spike' in Hebrew.
Subcellular Localization:
Nucleus. Cytoplasm. Cell projection, dendritic spine.
Domain:
The DOCKER domain may mediate some GEF activity.
Sequence:
MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEELEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQWHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRRSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKYLTETEDTVKTTRNMERLNLFSLDPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDPITNIEPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASVALENGNIDTITPRQSEEPHIKGLPEEWLKFPKQAVFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLVSDYRRADRISKMQTIPGSLDIAVDNVPLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEEFVYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMSFLPIILNQLFKVLVQNEEDEITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKERTVHEELAKNVTGLLKSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPESYQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISMFSSGDLKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQTHQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSTVMNEQITGRDDLSKRGVDQTCTRVISKATPALPTVSISSSAEV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MQLIRGLHNANRVLQGCALTIGNFDGVHLGHQTVLRHLRQKADELNLPMAVLLFESQPREYFMGKNAPARLMRLRDKIYYLEKAKVDVVIVAKFDRTFAEQLADVFIEQTLVNHLHVKFLSIGDDFKFGSKRQGNFAMLQAASKRFGFIVEDNRSFCLDAQRISSTAIREALANDDLQLAENLLGKPYRIFGRVIHGNKLGRTIGFPTANIRLHRQVNPIKGVYAVKVRLKSGEIFNGVANMGKRPTINGLMQLLEVHLFDFSQNIYGQMVEVEFCHKIRNEIKFPSFDDLKVQIEKDVETAKAFFNS
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).
Sequence:
MFVKLLPPEVRKVIAAGEVIESPVDVVKELVENSLDAKATKVEVEIVKGGKRLIRVKDNGTGIHPEDVEKVVLQGATSKIETEKDLMNISTYGFRGEALYSISSVSKFKLRSRFFQEKEGKEIEVEAGNILGTRRVGMPVGTEVEVRDLFFNLPVRRKFLKKEDTERRKVLELIKEYALTNPEVEFTLFSEGRETLKLKKSSLKERVEEVFQTKTEELYAEREGITLRAFVSRNQRQGKYYVFINKRPIQNKNLKEFLRKVFGYKTLVVLYAELPPFMVDFNVHPKKKEVNILKERKFLELVRELAGKEKPIVDIPLSQPVKTYKPTYEILGQMDETFILVKDSEYLYFVDQHLLEERINYEKLKDENLACRISVKAGQKLSEEKIRELIKTWRNLENPHVCPHGRPIYYKIPLREIYEKVGRNY
The following text describes a protein:
Function:
Acts as a protein folding chaperone for elongation factor 1-alpha.
Miscellaneous:
MISCELLANEOUS: Present with 39900 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocates to the nucleus after nutrient stimulation.
Sequence:
MSEQKEDLFKPVGEAAAEVEDESIAEQNKANDGVKLTGAQDAMGHPVQEIESLCMNCGKNGTTRLLLTSIPYFREIIIMSFDCPHCGFKNCEIQPASQIQEKGSRYVLKVECREDFNRQVIKSETATCKFVELDIEIPAKRGQLTTVEGLLSEMIDDLSQDQEMRKSIDEALYKKIDDFIQKVKSYINCEPNTIPITFILDDPAGNSWIEYKPGEPQHKWSHTQYVRTDEQNVQVGIITRDQLEQRRQEQLKQLANRERNPSESVKVGSANPQFLSDATDIENFNNEVQTFRASCPSCTQECETHMKPVNIPHFKEVIIMSTVCDHCGYKSNEVKTGGAIPDKGRRITLYCDDAADLSRDILKSETCSMVIPELHLDIQEGTLGGRFTTLEGLLRQVYEELESRIFTQTSDSMDEATKARWVEFFAKLKEAIAGKVKFTVIMEDPLAGSYIQNVYAPDPDPNMTIEDYERTKEQNEDLGLSDIKVE
The following text describes a protein:
Function:
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Subcellular Localization:
Cell membrane. Cytoplasmic vesicle. Lysosome lumen. Lysosome membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MKLLALGLVLGCLSVADAAIQVDQVDVFIGGTRGHACYRVPTAVTLPNNTVLMAVESRRTTCGDQAPKDIELVRSQDGGFTWSEPVMLVGSLTGNTTYRNPYLTVVPGSSTTATPDLVLLQFVNSTLDEPWTTFQMESRDAGLTWSSAQPVNLSAWNGTLAGPGLGITLAHTHPGRIIMCGASGYHAGHSANGVVWFSDDQGASYVVSAVFPEMQECQVAELADGTLLINFRNSHLNSSCDCRAQSVSHDGGLTWGPLTYIPDLIEPVCSAGLVAANDTLYFTNPNSRDQRINMSVQSSMDGGNTWSHEVTLWPGPSGYSVATNHPNSKCTLGVAYERGEQSYAERITFAHINLCYE
The following text describes a protein:
Function:
Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells. Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection. Contributes to the formation of the complex between UL128, UL130 and gH-gL.
Subcellular Localization:
Virion membrane. Note=Found as a pentameric complex at the surface of virion envelope.
Sequence:
MRLCRVWLSVCLCAVVLGQCQRETAEKNDYYRVPHYWDACSRALPDQTRYKYVEQLVDLTLNYHYDASHGLDNFDVLKRINVTEVSLLISDFRRQNRRGGTNKRTTFNAAGSLAPHARSLEFSVRLFAN
The following text describes a protein:
Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Sequence:
MDYPERVEYVAKQLGITAEEVREKLAHAPEDPTFCPDPANLPKHIDFTVLTAFSTTQDIINLCEKAKKFQTIAVCVNPNRVHICKEQLAGTNIRIASVVGFPLGATTSAAKAFEAKEAAAAGAIEIDMVIDIGALIEGDYKKVCQDIAEIVAAVPQCYVKCIIETCYLNEEQIIDASILTVLGGAHNVKTSTGFGTAGAKPEHVAIMRKVVGPKFGVKAAGGIRTKEAAHAVIAAGASRIGASSPALFE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSWAATGGSSALAAPPGPTATSSSSSSSSFLPRLSFWRSSCPLAAQEKSPSSAQEYFSTLLELPVLSPSIGTEVWLEERKGMKELNPASLQLEQGAAREGGKAGNGVQSEHVTEGPMWKAPEEGNKLPGLRMEQCWEAQWQQFLKTFQSPSWAWRSLPPAEEMPWDKAKDFLASFEQVAKACRWPKEEWVARLLPALSGEAEQAFQSLEAGDREDYGKVKAAILRAESLRAELQRQHFRQFCCQEVEDPRRVYSQVQELCSRWLKPERRSKEQILELLVLEQFLASLPQDLQGWIRGGGPESCSQAVALAEDFLLKRQQEADSARCQGLSQDVCVGSLDAERKSPDAAQGQIYEESKPVKDADIPLLSGGTQCPSPSISVFPPDGQVKTEAELGEGLLDCRDTGVPLHSVEQTLSQPGPQTIFWQVLQEEGGNTQPFGEVDSTLLKVETSQHGGDKLEERPGVAPLLNQRDGLLTAEPSGQRSDEKGCWKEMKISSQVEPSQRPTAPNIHKSGYRLMGQESKKYMETERKHTKSLIGADKKASTDVGKPLFSKYGRKYHSVSDGFVDLNPRKKDTKCPEEGETSKSHGQSLQRNQNVPTGRKLHKCVTCEKDFKSRADLLCHKRSHTGEKPYQCSQCEKCFSWKYKLVRHQLSHTGMKPYKCFQCGKCFAQRSHLKNHQRIHTGEKPHECCQCGMCFTLKHNLKDHQRIHTGEKPYKCSQCCKSFTKRSNMKVHQRIHTGEKPYKCSQCGKSFAERKTLKDHQRIHTGEKPYKCSQCGKCFPQRHTLKNHQRIHTGEKPYKCSQCGKCFSKRSNMKVHQRIHTGEKPYECSQCGKCFQRHSHLIVHQGIHTGKKPYCAPNVEKASLGNIC
The following text describes a protein:
Function:
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol.
Sequence:
MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGITYSEMRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE
The following text describes a protein:
Function:
May play a role in a redox process.
Sequence:
MKIITCFKLVPEEQDIVVTPEYTLNFDNADAKISQFDLNAIEAASQLATDDDEIAALTVGGSLLQNSKVRKDVLSRGPHSLYLVQDAQLEHALPLDTAKALAAAIEKIGFDLLIFGEGSGDLYAQQVGLLVGEILQLPVINAVSAIQRQGNTLVIERTLEDDVEVIELSVPAVLCVTSDINVPRIPSMKAILGAGKKPVNQWQASDIDWSQSAPLAELVGIRVPPQTERKHIIIDNDSPEAIAELAEHLKKALN
The following text describes a protein:
Function:
Ornithine carbamoyltransferase involved in the synthesis of arginine from glutamate via ornithine and the urea cycle.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSFKKFPRHLLSIRDLSRGEIVKLIDRSSEIKQAYKQNFQNRRSVQMSGLSSQNVAMIFSKRSTRTRVSVESAVSCLGGNAMFLGKDDIQLGVNESLYDTSKVISSMVSGIVARVNKYSDVATLAKHASCPVINGLCDTFHPLQALADLLTIKETFKSFDGLKVAWVGDANNVLHDLMIANAKVGIHTSVAKPKDVNVRDDILSIVNEAANENGSTFEIVNDPKVAVKNADIVVTDTWISMGQEAEKEQRLKQFTGFQVTGEIMKLAKPSCKFMHCLPRHPEEVSDEVFYGENSLVFQEAENRKWTTVAVLEALLVNRGEILPPASA
The following text describes a protein:
Function:
Protein kinase which is essential for spore formation.
Sequence:
MKKYLWGTPTTNTVFTGKQPKYTKEVRKCISIDEVYNVVRKVGDGTFGSVYLATTKTPSKEVVAIKSMKKKLAKVSDATRLREVHSLLRLSENENIVNIFDLYIDQFRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKPENILISSNSDSSSFNVKIADFGLAREINSRPPYTEYVSTRWYRAPELLLRDSYYSFPVDIYAAGCMAFEIATLQPIFPGNDDFDQLYKMCEILGSPDEQSQNTGDKGGGIWDRAELLANKLGISLPKMAPLDFGDLFSPPWNLAFASMLSQLLKWDPAKRPTAEMCLDLEFCRVSAPADAVASKEEVNKNTDFRVSISYFPSSSSIPDECNTEEESRINPSTSKFLKQLNKGFNGFTKPFRKSRKQSKNRKNKSSVATQFSEESEDIADSITSSTFFPVLPQIRPSTPLNLKLRNFIISSSEDSTSPKAKEFDRPLPSTEFLVAINKSQEALLNNSPNSKSGSTQLSASTCLSDLISPQLSILSHEDKRENQSVNSESSKYSPRSSNHSPTLHSKDLHRDMATVNNYAKSPPSFHATQDLLRKTLAYTNSSGTSTVLSNDSSAISSTFLDRDFPDFGITSLAGSLTLPDSKIIDRSKTHVSTQLLP
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAGEKAGAREAGVLVSSFLHLMISQLATRVISFLLNVLIDRRLNAAEIGLSAVQFPLITTTIFMISREGFRRGCIRSDLGDNPHQSAAARVVSVAWLSVPVGLLVTCATVGTILWWQQLPVADVRTQALLVLGVAAGVELLSEPLYILAQCLLLLRVRVVIETLATLGKSLVTYALLLQGIGKAGGLVFAYAQLTYALVLLVGYWGYFLSRARRRETTGASVPLLPSRPKGGPLLDPSLLRVCGAFSWQSVEKLALAEGEKFVLVLSGSQHNQGVYGIVEKLGSLVVRSVLQPFEESAFTMFSKAASSANKKDDDAQKPDVRGVERVLLLAIKGVSLLGLVFVAFGPPYSYTLLRLLYGRDKSDSEAPTALACYCLYVMVMALNGITESFLHATASERGLAWNNVALVVFSVCHVALSVALVQARGTTGLILANVCNMTLRITYSMVFILRYFKGSPTFSIRRAVPSIRVIGTFIAAALTAHWAEVTFLDHDRFYTSAATYIMVGGACFVGVLGAIYTAERSFFSEIASLRRGSSASIGDAATGVGVVDGDKKRT
The following text describes a protein:
Function:
RNA-binding translation activation factor that as part of the MRH5C complex specifically recruits cox1 mRNA to the mitochondrial ribosome for translation initiation.
Subcellular Localization:
Mitochondrion.
Sequence:
MSKSFAYRHIWCFWRFNTPLLWFPQPLKYWPAFQQSHTFNSMSVFKNDNAIANQTTVNESDVKRNVEKINDIYECSNNTKSPCFPNSDSRIPLVNWKTSTNPTLQVRAYMLDLLLPFFTLDLLPFLNKVCECCNHMLLDNPKIKQDLPFAFCYLFSSYFSYKSSRQYTCSSEEISKVFRHLNRLGGSEYVLHLFAQIPKALCKELTDVRTLNHPLRSIFTFCFKNISNPPNLLKLLTKLYPRSDRANEVLYTQYLGFLTKRGDYQIAIYMFDEMYRTHHWSSFTACRLMIESLVRQNKFEEAISLYKKIIAKRPKIARDKKILNLLLYISTVSNRSPDAFKLALQSISNANQIPSFDVFSRLMSALVKYNMTEMILPLVKQYDHKFRNLYSPNIFLSIVQALVFCGDMVNIQRWYNMSRVNSELSRIKHLLNCFLNSSTVSLDVSMVLELLRDLKKKKIKVDERTLVICITIFSRRKDLFAMEKIHQYFSDQGIKTSNQAYAALLDAYIEAEDTEKIELYLGKIRRLGITEDVSINRMLMRLALDRLDWDLLEQCTKVAERKDPEGQDYLSTITMLYHVRQHELNLALRIFSGIQKPNVVHYSIAATVLGNLNQLDQLLLLEKRMESEGKAPTALSLVAFVSSYCKQGAEGLDEAKRYMSKNFQPDKRALLFNPRTANDMTYPPSLFSSLIKEYTSLGDIKEAKQVLSTYLEYFSKNITSKPDIPFAIASMRLYCSLHDTVLSRQFWDLILQVAQQNFITTDIAAVVDDKNIPSPSGVIPAYKSALNVAAETYFSFLASVNSFQELDQEWSRLEKLGFEYDDSLQNKRIIWLLYDDRLDAAIKRVYNIFLSSKRIEELIPDASSQNSIISFFLSPDSPLYFSTLKALRDKLDMAVEDDFVRISQGILVPTVKYLQTIRRDNEILFNLLAKV
The following text describes a protein:
Function:
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
Sequence:
MQMLFDRKQDKFREECGVFGVFKDYTSELGEIFYPGLVSLQHRGEESSGISYTTSKGMITKKALGMVSNLFSKEDFYKMKYFSAIGHVRYSTSGNASIENAQPFQEETIDGSISLAHNGNLLNYLNIKYELEKKGTIFKSNSDSEIILKFILEKIQEVREIEKAIAYAINTLKGAFSVLILTEDKLIGFRDKNGIRPLCLGKIEGNYILSSESTSIDVVGGEYIRDVDPGEIVVINKKGIKFIKNKEVYCGSLCALEYIYFSRPDSIIDGINLSQFRIKCGEKLYEKYKSNSDIVMGVPESGNFAALGYSKESNIPYSIGLIKNSYVGRNFIKATEKERKRDINIKINAIKSIVQDKSIIVIDDSIVRGTSSKKVVSALKKAGAREVHFMVASPKINYYCNLGIDIKSKKELLSFQKTKEEMRKFIGADSLEFLSLIDMEQCLNKSNICTGCFDGSYANY
The following text describes a protein:
Function:
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m-xylene and p-xylene.
Subcellular Localization:
Cytoplasm.
Sequence:
MMRTHPVADRGDLHADHLDLAAARSWMSKVCGPHRLEAASPGLVQFQHHGNVLKSMCTTLGYIGYGTDVTITVEDAAAFNAYSLSLPLSGEQELCRGGLRLLSDVRRGVIIAPNERQELSIAGDCRKLQVVIGRTAMRKVLEEMLQRPIDTPLRFDPEMDALDGASASWWRTVRHISEEMARSELYAQAFFSSDLERALIKGLILAQPNNYSEALQQGLGGRPPHYLLRAREFLQANARETLSLEDVERAAGVSRFKLFEGFRRYFGVSPMSYLKHYRLAAVREEILASGGARSISTIALGWGFSHLGRFSVDYRKRFEETPSMTQRRAARRS