lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTTPRKDDSHLFTSVRPCQLKVQEEQQPQEKYVIAQPIFVFEKGEHNFKRPAEDSLDEAAELEFTGFLRKRVRSSSVTLRTTDSQSLGVRKNNVFMTSRLLQRNDDMNNVGQGPPVRPSDHVLRPAVLQPSRTQSCQKGGTTLGPGASKTCETKENTEHKMGFFLSPFCFQISEADSSLLSENLSNARSSVQMSTDPCISEAPSGGHPKEDECSFTSCSSDFVFGENMVERVLGTQKLTQHPLQNLSYAKEKSFKSLLKFPNVASNSEPIKNISLIESAAAFSSKPSQKCLLEKIDVITGEETEHNVLKINCKIFVFNKATQSWSERGQGVLRLNDTAGSECGTLQSRLIMRNQGSLRLVLNSRLWAQMRTQRASHKSLRITATDLEDDRIKIFLIQASAKDIGFLYAAIHHRLVALRSLGQQGDGGPAGKQADTVLPQVSGGSCDEDEDDITQVTKTGPDPSRWNHRQSIVCL
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
DGSFYIGDLNRVFLRHQQWKEVLPRVELFYAIKCCPLMPVIRLLAALGTGFDCASQNEIESVISIGVDPAKIIYALPCKPASQLQHARTRKVSLMTFDNEDELHKIQKYFPDARLVLRLLPDETGATFKMGSKFGCTLEEGKKLLVHAKKLDLNVIGLSFFVGDDCKSSIGMRLNLENSRKMFDFASSIGINMDLIDIGGGFPGNDKDQKLFLQIANDTRDTLDKLFPSECGVRIIAEPGRYFVESSFSIATSIVGKKQSEGIWCRIVFNAETTDIIFYYTNESIYLAFWKTFLKAGKYTPIVLKTKRFSDKAVHDTIIYGTTCDGTDIIAQNVALPELDLEDWLIWDDMGAYTVLCKFGFNGVMTTKAFYFVQEGAW
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFLAHVTPFYPNQLAAFPAQLTDLLRTSCLAMPSGLRYQVAQSLILLMNRKSLVIEDLLALFLDIQTLGDKNLRKLAFSHIVQTIRKMSITDPRHKSLHKIVFSMLEQEDETKAKRALVTLCELHKKKVWFGDKHDRVAIAICEACFHTSPRIRISSLRFLLDYDNINDEDDSDLRLCLTERLFTSKKKKQAKLQRAMRSIKRKQRASSENTTSTYSPLNHLNDAQNFAERLLPLIRPKPDESTVETNDKSSGETDDKSTGETYERRETRLMIIKVIARTIGLHKLLLFKFYTYLQAYAKDGVKDITQILAAAVQACHDGVPSDAVEPLFKQIVNKFLHDRSSPEAIPVALNVVREMFLRIPELMTEDLLHDLAQYKTDKKYRTHRKAISAASASLIALFREINPLLLVKKDRGRPGGPIARPKKYGEVNVFSNVPNVDLLQESDDDEVALPGSDDIEQELITEDEAEEDSNDGDDMNNTEDDTLVSGDEEEEKNDSDEAETDWENEEDEGEASVEGSGNREKAKGKKRKLVDFDASLLAADTSLRALKRCAEAEREQTSFAERDGILSNEDFRKIKEVKGKKDAKLALARKGLKVPDSDKLSKKLVNPAKLEAHIRQKLIKEERLELVKAGREDRGKYKSKTAIKQKKTGGSSNRQKEHKKNMPLAAVRSKAGKAKRVKKMKNSHSGSQFRGRKAWK
The following text describes a protein:
Function:
Major capsid protein that self assembles to form an icosahedral capsid with a T=219 symmetry.
Subcellular Localization:
Virion.
Sequence:
MAGGLMQLVAYGAQDVYLTGNPQITFWKVTYRRHTNFAMESIEQTFNGQADFGRRVTCTISRNGDLAYRTYLQITLPEIGQSLSSGAVYARWLDFPGEQLISQVEVEIGGQRIDRQYGDWMHIWNQLTLSKEQERGYFKMVGNTTQLTYVCDPNFAAIDGPCSANGVRQVCAPRDALPETTLYVPLQFWYCRNPGLALPLIALQYHEVKINLDIRNIEECLWAVSAIDGTGTKITDAYKQSLAAASLFVDYIFLDTDERRRMAQNPHEYLIEQLQFTGDESVGSSSNKIKLNLNHPCKELIWVVQPDANVDYCSSLTASTHLNNLLGAQPFNYTDAFDALPNAVHAFGGQASASGANAVINASGLFEDPFSNDIQSSVLDSGAATGADSGVSDAGTFVLAETALDMHCWGENPVIVAKLQLNGQDRFSEREGTYFDLVQPYQHHTRAPDSGINVYSFALHPEEHQPSGTCNFSRIDNATLQLVLSNATVQGVNTAKVRVYAVNYNVLRIMSGMGGLAYSN
The following text describes a protein:
Function:
May be involved in protection from oxidative damage.
Subcellular Localization:
Mitochondrion.
Sequence:
MSVTNLSWLKKKSQSVDITAPGFNPLAGAGKQMPQASKPPAPKTPIIEEEQNNAANSQKHPSRRSELKRFYTIDTGQKKTLDKKDGRRMSFQKPKGTVKYTVESRDSLNSIALKFDTTPNELVQLNKLFSRAVVTGQVLYVPDPEYVSSVESSPSLSPISPLSPTSSEAELEKTTTPDVVHPKEPTPSSAFTAVRPVRVVSSTSEEEEAFTEKFLKINCRYITSSKGTVSGVLLVTPNNIMFDPHKTDPLVQENGCEEYGIMCPMEEVMSAAMYKEILDSKIKESLPIEIDQLSGRDFCHLKKVTRSNTDELDSRIRDAANDSASTAPRSTEESLSEDVFTESELSPVREELISLDELRHDKSSGASSESVQTITQSGVECLAVISEAASTPDHLKSGSGHTANEVGTLSLKTGLNNLEMPTKEGDQAADNLQKISGLKEQSTGIKKDNQDFPLDENSLHQEEVEKESMPCGEAIELKQKQVVDKGKQGREQNQDSETEVEELRKLWKSHSMQQTKQQRETMQQVSQKEIKHKIATADIEGSALLKEKRRHRLHKFLCLRVRKPMRKTFVSQASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPETYAEDTGEYTKEPGFIVVKKIEESETNEDSTNEAAAREWEVVSVAEYHRRIDALNTEELRTLCRRLQITTREDINSKQSTPVKADLESESFRPNLSDPSHLLLPDQIIKLTKHLPPRTIGYPWTLVYGTRKHGTSLKTLYRTMTGLDTPVLMVIKDSDWQVFGAFASQPFKVSDGFYGNGETFVFTFCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGDLYHGRSHSCKTFGNHTLSKKEDFCIQDIEIWAFK
The following text describes a protein:
Function:
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
Sequence:
MPLEPSVRVVRELTSRGYNADREAVTLLAGADDPGAAVERAVAAAAADAATLTVSDVRAVLDAHTASSAAQTSAPASTPPDEATTHTDPSATDTPPNHDGGRAATADARSVEIDGDMTGASTGTGEYQDFVSVFRDRYDRLAAQLRGRVNHRPTSALASMPGGSDAAIVGMVNDIRSTTSGHWRVELEDTNGVFPVLVLKDRDVSDLVDDLLLDEVIAVSGTLADDGTILFADDIYFPEVPRTYSPSTADRSVQAALISDVHVGSQEFAADAWRSFADWLHTPAAESVEYLLIAGDMVEGVGVYPGQDEELDIVDIYDQYETFAEHLKDVPGDMEIVMIPGNHDAVRLAEPQPAFDEELRSIMRAHDARITSNPSTVTIDGVSVLLYHGVSLDEVIAEHPSDDVTYDDPQNAMELLLKKRHVAPPFGGRTRLAPEAEDHLAIDTVPDVFHTGHVHKLGVGIHHNVRLVNSGCWQHQTAFQESVNISPDVATAPILDLDTLDITVHKFS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that limits organ size, and possibly seed size, in a dose-dependent manner. Negatively regulates the duration of cell proliferation in leaves and petals independently of the major phytohormones (e.g. auxin, cytokinin, gibberellin, brassinosteroids, ethylene, abscisic acid, jasmonic acid), probably by targeting growth stimulators for degradation. Limits the proliferation of root meristematic cells. Polyubiquitinates DA1. Involved in the promotion of leaf senescence, in addition to its function in restricting plant growth. Possesses E3 ubiquitin-protein ligase activity in vitro.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing BB exhibit early senescence.
Sequence:
MNGDNRPVEDAHYTETGFPYAATGSYMDFYGGAAQGPLNYDHAATMHPQDNLYWTMNTNAYKFGFSGSDNASFYGSYDMNDHLSRMSIGRTNWDYHPMVNVADDPENTVARSVQIGDTDEHSEAEECIANEHDPDSPQVSWQDDIDPDTMTYEELVELGEAVGTESRGLSQELIETLPTKKYKFGSIFSRKRAGERCVICQLKYKIGERQMNLPCKHVYHSECISKWLSINKVCPVCNSEVFGEPSIH
The following text describes a protein:
Function:
Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain E2348/69, acts mainly via the host adaptor proteins NCK1 and NCK2. Once clustered and phosphorylated at Tyr-474, Tir binds to NCK proteins, which in turn bind and activate host WASL/N-WASP, leading to actin polymerization. Can also trigger an inefficient, NCK-independent pedestal formation. This pathway involves phosphorylation of Tyr-454 and probably a putative host adaptor. Also acts via direct binding to the host cytoskeletal protein alpha-actinin in a NCK- and phosphotyrosine-independent manner. This interaction may stabilize the pedestal, but is not essential for its formation.
Subcellular Localization:
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Secreted via the type III secretion system (T3SS). Released into the host cytoplasm via T3SS and then independently inserts into the plasma membrane from a cytoplasmic location. In host cells, localizes to the tip of the actin pedestal.
Domain:
The intracellular N-terminal region interacts with host alpha-actinin and is not required for pedestal formation. The central extracellular region (amino acids 277-332) is involved in bacterial intimin binding. The intracellular C-terminal region binds to host NCK.
Sequence:
MPIGNLGNNVNGNHLIPPAPPLPSQTDGAARGGTGHLISSTGALGSRSLFSPLRNSMADSVDSRDIPGLPTNPSRLAAATSETCLLGGFEVLHDKGPLDILNTQIGPSAFRVEVQADGTHAAIGEKNGLEVSVTLSPQEWSSLQSIDTEGKNRFVFTGGRGGSGHPMVTVASDIAEARTKILAKLDPDNHGGRQPKDVDTRSVGVGSASGIDDGVVSETHTSTTNSSVRSDPKFWVSVGAIAAGLAGLAATGIAQALALTPEPDDPTTTDPDQAANAAESATKDQLTQEAFKNPENQKVNIDANGNAIPSGELKDDIVEQIAQQAKEAGEVARQQAVESNAQAQQRYEDQHARRQEELQLSSGIGYGLSSALIVAGGIGAGVTTALHRRNQPAEQTTTTTTHTVVQQQTGGNTPAQGGTDATRAEDASLNRRDSQGSVASTHWSDSSSEVVNPYAEVGGARNSLSAHQPEEHIYDEVAADPGYSVIQNFSGSGPVTGRLIGTPGQGIQSTYALLANSGGLRLGMGGLTSGGESAVSSVNAAPTPGPVRFV
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated.
Sequence:
MEGFAKWSNYWDKKEMIETPRGTFNVYSNPCDSNFVLFCVHGIGHSALSFSLLAKELKGQLTVVAPDFKCHGDTPGDESKDLELNSMVEDFIALAEIFIPKDKRAILLGHSVGGSVVTFAASKVPSMSIIAIDTIEGSTIQQLPGMEKLLHKRPQAFESANDAIAYVATSGEMENFDSAKISVSGRMKETADKKLTWKTDILKSKEAWPGWFKGFADAFIHAHSYKILILPTIDRLDTPFTIGHMSGKFQLSVINGTSHCVHEDAPDKVADVIMKMVKRIGASSQW
The following text describes a protein:
Function:
Neuropeptide that controls movement such as roaming, foraging and backwards locomotion or 'reversals' in response to environmental cues such as food availability or volatile odorants such as octanol. Antagonizes AIB interneuron activity to control bacterial colonization and may negatively regulate the expression of immunity-related genes such as pqm-1 and dod-22 in response to infection by P.aeruginosa.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEFENLTKEEMEQLQKIYDDTISFERKIGIIIPTIFAVIILVGLVGNALVVIVAFGRQMRNSTNTLIIGLAISDLMFLLLCVPFTAVDYAAPTWIFPEWTCSMINFFQHTSAYCSVWTLTLMALDRYLAVVYPVESMTLRTPRNTVIALCFIYIIIIASQIPVGRMHGIYVYDFIMEKRSTCAILTIATAEATPTMARTYFMTFNVFGYVLPLGISVVLYGLMLRKLWDMPRPGNSQSVGGRNLTNRDSGSSIRRRPEATAAKRKVTRLVLCVLITWALCWLPLNVCFFMSGLAYPEPLVISHGVIMVIVQIASQVLAYTNSCLNPILYALMSQSFREGFIRVMKMLINKLSRGRFCTNYRRSALRTELTHYNQTPAHPANTVVQVSNGERSSLLKDNSSSATSVQPLRTSIQAKKTKNIGRSKSTRSYNL
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
ICAECLFFSVIRELNKRERNSSREREREREREREKAALLPFNLSLHFNHHYLSEIEFLFFFFLFFFIDECFSRLIISFSKENIMGSTIKLQINRHSIYILLFLLLSIFTTSPSHFMVQGRQLVPGDNLARKKGERNIIMRSQLIGSRPPRCGGSCEAVQIPIIKFEIAYSRGDHISNYKPICWKCKCGHLIFDP
The following text describes a protein:
Function:
Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.
Subcellular Localization:
Nucleus.
Sequence:
MMKTSPRRPLILKRRRLPLPVHNAPGDTAEEEPKGPPAQQEPAQAQAPKEVAEPNPCKFPAGIKILNHPTMPNTQVVVVPNNANIQSIITALTAKGKESGSSGPNKFILISCGGAPTPPPGPQHQAQTSKDPKRTEVITETLGPKSATGDENLPRPAGALPGQKWKNCAGGEAASCPLDNSLTNIQWLGKMTSDGLGSCSIKQEVEEKENRHLEQSQAKSPQVERPPGASAPWPDSVSERPPYSYMAMIQFAINSTERKRMTLKDIYSWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSAHSPEHSESQQKRPNPDLRRNVAIKTELPLGARRKMKPLLPRVSSYLVPIQFPANPSLVLQPSVKVPLPLAASLSELARHSKRVRIAPKVLLADEGVASLPTAGPVTEEKLLLAEGLSPLLPVPSIKEEDVHPGEETPHLGRPIKVESPPLEAWPSPCPSVKEESSHSWEDSSCSPTPRPKKSSSTGSRSPTRRVSDLLVIKRREGREMSRSRRKQHLVPPRLEEPELLLSEGPGAPQPALAGPPQPTCQPGSPPEDGGPFKTPIKEMLPTSSTPSKSALPTTPESWRLTPPAKVGGLDFSPVRTPQGAFGPLPGSLELADLSATPLKSVPLFDSPRELLNSEPFDLATDPFGSCLPSDMEVPKPGSPEPQVAGLSANRSLTEGLILDTMNDSLSKILLDISFPGLEEDLLGPGSVGWTQCIPDLR
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Cytoplasm.
Sequence:
MARIIDVSELDYAAHSLTRGGLVALPTETVYGLGGNALDERAVQQIFEVKGRPSTDPLICHVPDIQRAVGLWDSNADPAALEVAKWIGDAIWPGPLTIVFRANSVLPPSVTGNSGYVGVRIPNHPIALQLLQLVNFPVAAPSANTFGHVSPTTAEHVLRDLGERCPSLLVIDGGHSNIGIESTVLKVASATKVEILRRGKVSLADLQQVIWKKFACHITVRDTRSCPGTVDMAMDGPGQLLTHYSPSVLSGMLTPKSTNCEVHQNELDKAVVELPSTPPLTGGVPLNQTVIIDFGGLLQRFQRVCLAYRDLSAEGEVQQACFAVFEALRWSETVSGAGVVLFPLISEWPCKTGDEELLAAVEDRLFRAASGKIANIRFG
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGARSLSVLLLPLLLAAAATPAPRDGEPRSCEAVRKVFQLRQLGSLRGVPEFPRAGVDLQVCTSKNPTCCTKKMEERYQTAAKQDIQQVLQTSSATLKFLISHNAAAFQETFEMLIKLAENYTSTLFCNAYRNMAAEAATHVQEFFTDVALFVFGTDISIEEFVNRFFDTLFPVVYNHMINPGLTDVTLEYAECLQMARRDIRPFGNIPKKIIGRMGRSLLPSRNFLQALNLGIEVINTTDHLHFSKDCSRALLRMQYCPHCQGLILSKPCMGYCLNVIRGCLAYMAEVDLHWQRYIQSLEELSSAMHGTYDVEHVLLNFHSLVNDALMQARVNGPELTEQVKKVCGPPVRKSTQSPHCSFDQNKYYQGLKMFSRDSEETLASRRKEFISHLRLYRAFYGGLADQLCGNELAAADGLPCWNGEDVVKSYTHRVVGSGIKAQSGNPEVRVKGADPVINQIIDKLKHVIQLLRGKSFPKYDNWDLRQTGSGGSVDEQMSGDCDDEDGCRGSGSGEVRRVLKITDWMPDKTNLSDVKQIHQTINASILHTTGAGCTAIVDYVTFMLISLVTLFLW
The following text describes a protein:
Function:
Acts as an inhibitor of the CDC28/CLN2 cyclin-dependent kinase complex. Stabilizes the CDC28 inhibitor SIC1. Negatively regulates the G1/S phase transition. Contributes to osmostress-induced transitory G1 delay.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the nucleus upon osmotic stress.
Sequence:
MLLERLHKRLHAGSSRRSQENKDKNCKPEDALPIQPEAQHQTQDPQPLLNCDYDDMIAFDRNLSTPVFTPVMTPINNSSSNQAKSSDASYFPPYLNANRTRQNSASSLASSVSDFAQNFKQHTFYNNNAQFTSFTPQFVGLLLEVYQNTCSDPTITPFDTTNPPSGILNRVAKAAIQQSELQQLDIGCDRNSWLLTLVRQRLLQEVRKDGYLSRNTSLTSLPPPPPPQFSEMLRVPSPFVNADITDPIPLSNTNSNPNVSSTTSLTNTLNWYSLQRSNVSMKNRNGSSQYISELQPQPILARTNSNNSVSNSNAFSLLTPTPTTDSAFNFNIALLSRQRSNIISSPLASTRLPTANVSTEESSILPNESLKLKRDLLRLKR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MNLRWMEAVLPLGIIAGMLCVMGNAQYYIHKSAHGRPKHIGNDMWDVAMERRDKKLVEQASPSN
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MRKGNMELETNKVYDYEDARGNDAEVPDTAHQISTDSWFQVAFILTTGINSAFVLGYPGTVMVPLGWFGGVIGLILATAVSLYANALVAYLHELGGQRHIRYRDLAGFIYGKKAYNLTWVLQYINLFMINTGYIILAGSALKATYVLFKDDGLLKLPYCIAIAGLVCAMFAVCIPHLSALRIWLGFSTVFSLAYIVISFVLSLKDGLRSPPRDYEIPGEGVSKIFTIIGASANLVFAFNTGMLPEIQATIKQPVVKNMMKALYFQFTVGVLPLYLVAFTGYWAYGSSTEVYLLNSVNGAVWVKALANITAFLQSVIALHIFASPMYEFLDTKYGIKGSAMNVKNMSFRMVVRGGYLAFNTFVAAFLPFLGDFMSLTGAISTFPLTFILANHMYLKAKKDKLNSSQKLWHWLNIGFFSIMSLAATISAIRLIAIDSKTFHVFADL
The following text describes a protein:
Function:
May be involved in the degradation of peptidoglycan by catalyzing the cleavage of the terminal D-alanine residue from cytoplasmic murein peptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEELGLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDFSLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLFQETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDEEPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPALRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MAAAAAAAPESYIGSLISLMSKSEIRYEGVLYTINTEESSIGLRNVRSFGTEGRKKDGQQIPASDKIYEYILFRGSDIKDLQVKSSPPSQSATLHNDPAIIQSHYPHPASLSTSLPSAASTTTANPTSHNAPSMIQMPPPFQGNLPPYQSGTSLQSWNSSPMPSSANGTGLTMPPMYWPGYYTPPTGFPHLQPPPFLRPPHSLAVPQALQLPIQYPGLGSLPTGFPSMPELPSFLQPGNSNSLSQTSGVPTSVSVPASLSTSETESSRSQLPNKWSSDSASVVSVSFAPPSVTPSVSTDEPSMPVSQVLPSLVNSKPVALPDSTVPSLSTDKPVIVLDASVPTYLSSSQPPSANDASPVNVAEQVPLVTPGQLLATTSSTIVSSHALQTSAVVPSSKAVPSSVPSSQATLSVASPTQVASSSVLSQQVEVTSESKPAKQREWKAKQPVVATPGNKKALLPAPKPVLQKPVGVSSYVQYNNRGRGRGRGHGRGNGQSHPITKFTEDFDFMAMNEKFNKDEVWGHLGKSIGQLNDEPNGYGDVLEDDEISPRKPEAMAVYVKDDFFDSLSCNTIDNGGRNGRVKFSEQRKIDTETFGDSARHRPTGIRGRAPRGGGGGPRGRGYYGRGYGYMGRGRGYSYPNHQS
The following text describes a protein:
Function:
Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. APC11 is required to recruit the ubiquitin-conjugating enzyme E2 to the APC/C.
Miscellaneous:
MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
Sequence:
MKVKINEVHSVFAWSWHIPSTSDEDAANNDPIGNDEDEDVCGICRASYNGTCPSCKFPGDQCPLVIGLCHHNFHDHCIYRWLDTPTSKGLCPMCRQTFQLQKGLAINDAHVQKFVEIVSRRREEMIEEGVAEEFVDFDEPIRQNTDNPIGRQQVDTILDEDFLLR
The following text describes a protein:
Function:
Extracellular serine carboxypeptidase that contributes to pathogenicity.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MVSPSDESVLSSLLASWVTRVLPSLSMPSLTSVVGLSASLVGLVAGQYFPPTPEGVKVIHSKHQKGVTISYKEPEICETTPGVKSYSGYVHLPPGTLNDLGLDQQYPINTFFWFFESRNDPVNAPLSIWMNGGPGSSSMIGLMQENGPCRVNIDSNSTELNPWSWNNYVNMLYIDQPNQVGFSYDVPTNGTYNQLTGVRDVSGWSTVPEQNNTFYVGTFPSLNASATANTTENAARALWSFAQTWFTEFPAYKPRDDRVSIWTESYGGRYGPSFSAFFQEQNEKIANGSLTTPGESHYIHLDTLGIINGCIDLLVQAPSYPEIAYNNTYGIEAINETIYEFAMNAWSKPGGCKDQIVRCRQLAAEGDPRMYGNNKTVNAACQAADRYCSNNVEGPYPLFSGRGYYDIAHFDPDPFPPPYYLGYLSQHWVQDALGVHINFTESIDSVYNAFGTVGDYARSDVRGYLEDLAYVLDSGIKVALVYGDRDYACPWNGGEQVSLQVDYSHADKFRAAGYAPLHTNSSYVGGSVRQYGNFSFTRVYQAGHEVPAYQPETAYEIFHRAMFNRDIATGKISTAKNSTYSTKGPSSTWNVTNTVPDSPEPTCYILSLSSYCTEEQTQSVANGTALIKDYIVVEESL
The following text describes a protein:
Function:
As part of the exocyst, may play a role in regulated exocytosis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle.
Sequence:
MSDGDKNGRDNHEEALVPVEVWQELERAECLARGAALKWASGVFCRPEHLEKLGQYKKRESQRTASIQSRLKSVVQSYLEGVDWGLGQLREARAELRGVSHDLYKANLESRKNSEEVTTLETLREISVSHCQLLAAVSNLPRLYKVRSMVLETERLVESRRLLEAHARLMELERWQDEVLLQLQGPRGSSGTELNSEDEELVRNYFSGVGRLVDALAKELWAVVGSGLSLAHQNPTPFVSAVRIVEREEALDQFFLEERRSTSGHNIPMPAGRPRNWRDRFFKVMEEAVSARFRSVSYLHTRGPGLASHLSALQHCIMGDLSTVRHCLEQCVPAHYHLTRAYLHFCHQFLQTHLGLVSGWELEGGEIFAVLNWVLHIYNSSEMMGEPALLAELEIENLGPLISQEGLEQLQNKYVQKVRKSVSEWMQKALEVELTDWQRDQEPDIDHEGYYHTSLPTIITQMLEENARVALMISEALRDQTIQMGLYEMEKLLSRFRDAVIEFGKEHRKDPTVNKFYLHYLLACINNCIILKTSTESLQQQICSFVSNRYSRIPLGPLAALDRAVRKACRLVMDHLLFELQPHLQELLSSTWLDQGDVTLNMCGVLERHCELYNRVRQPCRQRLKEECQWLTVVEYVRAVMQKRLVCRSSDEQKQLAQRMTQDAQQLRDHLQSMEIDGTIGEVNPTALIAALADIINLKDPGMLLLEISGLLSKYPDISEEHVSVLLDIRGDVPKEVRKSVLDFLDQSAPPLPPGYRPIFTEILVPSSSIPFCLPTAKCT
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL
The following text describes a protein:
Function:
Involved in the synthesis of the atypical nucleotide dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate). Catalyzes the condensation of aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation respectively by host PurB and guanylate/nucleoside diphosphate kinases to give dZTP. dZTP is integrated into the viral genome instead of adenine by the viral DNA polymerase. This Z-base probably completely replaces adenosine and forms a triple bond to the opposite T-base. The resulting non-standard viral DNA is called Z-genome. The chemically modified DNA is probably harder for the host bacteria to digest with nucleases or restriction enzymes (Probable).
Sequence:
MKNVDLVIDLQFGSTGKGLIAGYLAEKNGYDTVINANMPNAGHTYINAEGRKWMHKVLPNGIVSPNLKRVMLGAGSVFSINRLMEEIEMSKDLLHDKVAILIHPMATVLDEEAHKKAEVGIATSIGSTGQGSMAAMVEKLQRDPTNNTIVARDVAQYDGRIAQYVCTVEEWDMALMASERILAEGAQGFSLSLNQEFYPYCTSRDCTPARFLADMGIPLPMLNKVIGTARCHPIRVGGTSGGHYPDQEELTWEQLGQVPELTTVTKKVRRVFSFSFIQMQKAMWTCQPDEVFLNFCNYLSPMGWQDIVHQIEVAAQSRYCDAEVKYLGFGPTFNDVELREDVM
The following text describes a protein:
Function:
Could be involved in mycobactin synthesis.
Sequence:
MSTNPFDDDNGAFFVLVNDEDQHSLWPVFADIPAGWRVVHGEASRAACLDYVEKNWTDLRPKSLRDAMVED
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site; The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain; The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Sequence:
MQISLVKIRNKFKQRNRGSFRQWVGKLSNGLMIPIAVLPLAGIFLGIGDAISSNSSGIVGVKFFGEFIKQGGNVVFANLPILFAVAIAITFSQDAGVAGFSAFVFWATMNAFMSSLIIPVDANNTASGYNILYWKAVPQSAIASTLGLNSLSTSVFGGIIVGALTAYLYNKFYAIRLPDVIGFFSGTRFVPIICMTIAIPVALLLLMVWPGVSILLNLIGTGLGILGGRGYGANSLIFGYIERALIPFGVHHAFYAPLWYTSAGGSLQEIANQQVWIRAPGSDYVTRVIGWEDFNTPGKWVIPAALANGTSGMMNGATTTGQDSTSALSKYMSKESTNFLSWKELVDGLTRKGNFDELAKNGLLDGSNKIWIGLNQSGILGKKVLLSDGKDYTITFKTFANTTPTFWSHGAHALLPISGTPSAITNGVTVNGTANSKTYNVSQFTVAVPSLNPAQYSQGKFPFMLIGIPAAGLAMILAAPKGRRKEASSIIGSAAFTSFLTGITEPFEFTFLFLAPWLFYGIHAVLAAVSFWLMNLLSANVGQTFSGSFIDFILYGALPDGRGWLANSYLVPIIGIFLALIYFPTFYFLTIRFNLATPGRGGKLITKKEYLAAKAAQKTDQTTNTNFNQTQIEAGMLLRAYGGSENIAELGACITKLRVTVKNPELVNETIIKDLGAAGVMRTTPTFFVAVFGTRAAVYKSAMQDIIQGKVNWTELQKVLDKNDSTVEKPEIKPTPVLKVQDEIVILSPVNGTLKPLTQVPDDTFKNRLVGDGIAILPSDGHFKAPGDVGVKTELAFPTGHAFIFDVDGVKVMLHIGIDTVKINADKKPGEQLEVFDVKTKQGEYTKLKSESVVEVDLKKLKRKYDPITPFIVMQESLDNFKLVPIRQRGEIKVGQPLFKLIYKDKKS
The following text describes a protein:
Function:
Receptor that accelerates the import of all mitochondrial precursor proteins. Seems to act in conjunction with mom19.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MAPTIPPPSVPIPAATPVTVPADSSIWDRVSNWVSEHKAVVYTIAGVSVVITTAGVVYYLRKGSEQKESGPKLSKKERRKRKQAEKGEAEKASTSKTEEAAPTQPKAAAVESADELPEIDEESVVRLSEDERKAYAAKLKELGNKAYGSKDFNKAIDLYSKAIICKPDPVYYSNRAACHNALAQWEQVVADTTAALKLDPHYVKALNRRANAYDQLSRYSDALLDFTASCIIDGFRNEQSAQAVERLLKKFAENKAKEILETKPPKLPSSTFVGNYLQSFRSKPRPEGLEDSVELSEETGLGQLQLGLKHLESKTGTGYEEGSAAFKKALDLGELGPHEALAYNLRGTFHCLMGKHEEALADLSKSIELDPAMTQSYIKRASMNLELGHPDKAEEDFNKAIEQNAEDPDIYYHRAQLHFIKGEFAEAAKDYQKSIDLDSDFIFSHIQLGVTQYKMGSIASSMATFRRCMKNFDQTPDVYNYYGELLLDQNKFQEAIEKFDTAIALEKETKPMCMNVLPLINKALALFQWKQDYAEAEQLCEKALIIDPECDIAVATMAQLLLQQGKVVEALKFFERAAELARTEGELVNALSYAEATRTQIQVQENYPELASKLQGMSGGPGMR