lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSEVEEDPFMLMNADELKIYIAQLQRESANSRIKTSEGSKDLMSFIQDNTANDPLLTGIDSKTNPFIEKKDCILF
The following text describes a protein:
Function:
Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MINFDEFPPKYDPSLRPPALTTGLIVFTFMLCVIKSVTSYTFESLILYPRAPLDLNLNSISLYSLFHVNFFHWICNIFTLATPLAVFETRNGTIHTGVTLNLLTVIAALQYCIVGLIFYPNTGVIGLSGIAFSLMSYMAYHESKFRPIMHTFHLSNSLEIKLYTLYVPFVVAIVFMILFPSSSLPGHLFGITTGYLLSYGYIDKLYPPSKVITTIENKLSSLINFLELIVTFYKEEESLVTRGSVGYKPLFNQDIEHGAANAASHGSSAFVGETRVLGTRESTV
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28.
Sequence:
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLPA
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Modulates seed size by negatively regulating the cellularization of syncytial endosperm.
Subcellular Localization:
Nucleus.
Sequence:
MSDFDENFIEMTSYWAPPSSPSPRTILAMLEQTDNGLNPISEIFPQESLPRDHTDQSGQRSGLRERLAARVGFNLPTLNTEENMSPLDAFFRSSNVPNSPVVAISPGFSPSALLHTPNMVSDSSQIIPPSSATNYGPLEMVETSGEDNAAMMMFNNDLPYQPYNVDLPSLEVFDDIATEESFYIPSYEPHVDPIGTPLVTSFESELVDDAHTDIISIEDSESEDGNKDDDDEDFQYEDEDEDQYDQDQDVDEDEEEEKDEDNVALDDPQPPPPKRRRYEVSNMIGATRTSKTQRIILQMESDEDNPNDGYRWRKYGQKVVKGNPNPRSYFKCTNIECRVKKHVERGADNIKLVVTTYDGIHNHPSPPARRSNSSSRNRSAGATIPQNQNDRTSRLGRAPPTPTPPTPPPSSYTPEEMRPFSSLATEIDLTEVYMTGISMLPNIPVYENSGFMYQNDEPTMNAMPDGSDVYDGIMERLYFKFGVDM
The following text describes a protein:
Function:
Hydrolyzes ribosome-free peptidyl-tRNAs (with 1 or more amino acids incorporated), which drop off the ribosome during protein synthesis, or as a result of ribosome stalling; Catalyzes the release of premature peptidyl moieties from peptidyl-tRNA molecules trapped in stalled 50S ribosomal subunits, and thus maintains levels of free tRNAs and 50S ribosomes.
Subcellular Localization:
Cytoplasm.
Sequence:
MPTYKLIVGLGNLGKKYEKTRHNAGFMVLDRLASLFHLNFDKTNKLGDYLFIKEKAAILAKPATFMNNSGLFVKWLQDHFQIPLANIMIVHDEIAFDLGVIRLKMQGSANNHNGIKSVIRHLDTEQFNRLRFGIKSQNTSNILHEQVMSEFQNSELTKLEVAITKSVELLKRYIEGEELQRLMEYYHHG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MADHKKPADQQNKRQRVSENAESSSKKFSIKEVVGSGVTGTRPFASPSPVAKAKPIAVVKPTAAMVAVTGPVATMAPASAEPSPVAKAKPTAATVTVTGPVATMAPAPPSPVAMKMPTPAAPSPVVTMAPATAPPSPMATMTPAQVAPSPVATKTPAPAEPSAVATMAPAQVVPSQVDTKTPAPAEPSAVATKTPAPAAPSPVATAMPAAVVNPPATVKHEPEDGGVLELDEQVTAAMVAVAPAEEEAAILEVKKKWLHCAACPAPLKRPIFMCGNGHVVCCACGGGGNGNGDGGANKHCDLCGRATAYTHIPYMDGLVDAYQVPCPYRNFGCARSIAYHSAAEHLDKCAHAPCYCFECAFQGSPASLLRHLTEESGRHCWPMEKIKYQICRPLVVPASEHRLLLVAEEDGRVFLLAVGAGRGAAGVRPVNVVCVRGNVDADARPVYTGVLWVDGPPAAAGHLRSSFQLKGDVANCGVPGEVDMEHGRLHAHVNPEMLHGESKEIHLRICITKFW
The following text describes a protein:
Function:
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.
Subcellular Localization:
Cytoplasm.
Sequence:
MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors; The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.
Sequence:
MVLTLGESWPVLVGKRFLSLSAADGGDGGHDSWDVERVAEWPWVSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERVVQWPAIVYKSLLDKAGLGSITSIRFLGDQQRVFLSKDLLKPIQDVNNLRLSLMDNQNVSKEFQALIVKHLDESHLLQGDKNLVGSEVKIYSLDPSTQWFSATIVNGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNFVTCGNSTRIGTVKRKSSENNGSLVSKQAKSCSEASPSVCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQILPEELSSCLNTKAEILRTKPDVCKVGLLSSKFPQIGTGDLKPLSEPKDNCTQLKTNTDKENKLESVSQSSTGLPKEGVPTKPSTAEVEIASTPELQKHLEYAPSTSDVLSNKPEEKAGVVSNSPNSCVEKKIETSTLGCRSQTLKESSVKIDNESCCTRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDVKQTSFAGEKPSLGAVFQQNPLVLEPVPVAGEAASKPASSMKPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTSSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTDLWKPESFRKEFGNQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCDQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQARNIILYSLYTKNFCICVTDVTCVFQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGKP
The following text describes a protein:
Function:
Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).
Subcellular Localization:
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).
Domain:
Tudor domains 2 and 3 have higher affinity for arginine-methylated peptides, tudor domain 1 is a poor binder due to an impaired aromatic cage.
Sequence:
MSVKSPFNVMSRNNLEAPPCKMTEPFNFEKNENKLPPHESLRSPGTLPNHPNFRLKSSENGNKKNNFLLCEQTKQYLASQEDNSVSSNPNGINGEVVGSKGDRKKLPAGNSVSPPSAESNSPPKEVNIKPGNNVRPAKSKKLNKLVENSLSISNPGLFTSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSAHSIVCRPVQPNFHKLENKSSIETKDVEVNNKSDCPLGVTKEIAIWAERIMFSDLRSLQLKKTMEIKGTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATKPLLMEQYCSIKIVDILEEEVVTFAVEVELPNSGKLLDHVLIEMGYGLKPSGQDSKKENADQSDPEDVGKMTTENNIVVDKSDLIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSETPHVSVSKVLLDAGFAVGEQSMVTDKPSDVKETSVPLGVEGKVNPLEWTWVELGVDQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGIGVELTDLSTCYPRIISDVLIDEHLVLKSASPHKDLPNDRLVNKHELQVHVQGLQATSSAEQWKTIELPVDKTIQANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQLIIMLLKNFMLNQNVMLSVKGITKNVHTVSVEKCSENGTVDVADKLVTFGLAKNITPQRQSALNTEKMYRMNCCCTELQKQVEKHEHILLFLLNNSTNQNKFIEMKKLLKS
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Sequence:
MISLSAILRPSFCLPLITRRALHTSTYHLQNKAVQPQTPATGNVDLGAPVTYISKSHDPWFNLSYEDWLLRNTPHDQPVLFLYRNFPCVVIGRNQNPWKETTPKKLREESIPLVRRRSGGGTVYHDMGNTNFSIILPRLLFTRSHGAQLISRAIRETLGITGCGVNDRNDVVIRDGDREYKVSGSAYKIIQHRAYHHGTMLISSSLAELGKSLRSSSPKMETKGIASYRSPVTTLNHYLPPWQSKHLHHDDFVRAVTAEFAKTYAGEEKPMTTCEVTESIIKDQKIWNGYEELKSWEWQYGQTPEFTNELEGNFSFGDLSIPIAARHAVITSMSIHLTPPLHSSTEETSIKQAYLDSLALSLVGRRYESLEGFEGAMGEEWDDEHWRDLGNDIVSWLRKHM
The following text describes a protein:
Function:
Involved in the export of mRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus.
Sequence:
MNGFGNVNQLSTLAAQHQEQSRSKIAVRGWQNATQQDLLNFVARKTRIGIQDSYVQGGQIIGFVNKQDVPALLKFNGIRFAGNALKFEKLDEDGTGATTSNTITLLRNFLMKRYNVQTKMLDLGGLYADPDLTQHGLVSSMSTQSKMFMALMKLAGSEPQLVVESVNLSNNGLKDVNSITSLAQTFPRLRNLCLANNQIARFQSLEVWKNKFRELRELLLMNNPVANDPMYRSEMLRIFPKLVILDNNLVRDEQRLNALYSLPMRLQQFFFENDTLGSSAIDFVTNFLRLWDTDRKQLMALYTPQSQFSVSVDSSIPAATVPEADQSPSFGHYLPSSRNMTKVSSEKSKQERLGMGPDAIGNIFKALPGTKHFLQEQPEKYSLQTWTYSQVGGFVITLHGFFEEVSKPEVENTKSYSYNARHRRYNHGQQNSAQNKLSKKSFDRTWTIVPTQGSVIIASDLLTVRPYAAGAWIRVDEPKKTPTADVSQGAQPVAVPAAGPQIPGPPLTNTMVPQPMGIPSTLQLPPEVQAKLSPIQLQLLNRLHQDTKLNAEYTYMLAEQSGWDYDVALKSFQSSVNNLPRNAFV
The following text describes a protein:
Function:
Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB.
Miscellaneous:
MISCELLANEOUS: Present with 2230 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MEIKEVDDRAELLRYTNNIPLLGKLVNHQPLWSTNPKLKSFSLEKISAPDQRRVQEALVVKDLLNVLIGLEGTYIRYFNDYEPSDPETPIEFKIAKKMDPSFKTFSRRIVRYGKQYMILTRAYEKWSDTSFGMVLQRFAYEIRRFLEDVYLKTLVERLERDFNKVPNFSIRELEQIINETEVNKQMELLYNIYEEIFREIEERRTNQSSQEDFNNFMDSMKNESSLHLRLMVAFDTTVYPVPKGGAILKIFQQKILENLGDRSSVMFLKKLLNNISQDYCTMLYEWLTQGILNDPYQEFMTYDDLEGKTDNIFDTRDRAWDTQYFIRKDVLLRDCDSEEDKNLLFKMLRTGILLKVVRASLQIPTIPSNSSDITIQEINDFADLMEGSNLELYVDKCYSRANEIFLKLFFQGYDLINVLKHLQQIFLGYQSGHNVLKFLTKNMGELTKHYRNDNNANYDKLLQNFELERQSENPNNLMRQLLMIQFDTETLPQVLSHYLQIYPEVPENNSANDDSDPLMHANNFKNMNAILFDELSKERTGAYHGSNLELYTPKSAIYHLKFDINIPYPLNIIISRTCMIKYQIILRYQLVLQYHSRLLDETWMDLNKTPSWKYRGYSHTVKRRIVRATRVLHAKMNHFIKTIMEYFNQNVIDKEVYSLEKCYRNPTLAVAIQNELEGGLTNIMTNRCLSDLIPLQLQIFDIVYKFCKFIKSMRAKLCQLDPVLYEKHKSGMMKTLNEGYRTNNGGQEDVGYQEDAALELIQKLIEYISNASSIFRKCLINFTQELSTEKFDFYDSSSVDAAGIERVLYSIVPPRSASASSQR
The following text describes a protein:
Function:
Metalloprotease. This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly.
Sequence:
MQCAVLLVLLGVVAASPIIPEAARALYYNDGMFEGDIKLRAGRQPARVGAAILGDEYLWSGGVIPYTFAGVSGADQSAILSGMQELEEKTCIRFVPRTTESDYVEIFTSGSGCWSYVGRISGAQQVSLQANGCVYHGTIIHELMHAIGFYHEHTRMDRDNYVTINYQNVDPSMTSNFDIDTYSRYVGEDYQYYSIMHYGKYSFSIQWGVLETIVPLQNGIDLTDPYDKAHMLQTDANQINNLYTNECSLRH
The following text describes a protein:
Function:
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
Subcellular Localization:
Nucleus.
Sequence:
MLSGTSKSRRSYNYQRSETGGTLIACSPRECAQRTHKHTSTVCCITRQYMAALLGEEPRASSSNPLAMLAATCSRIGEPTLSYAPSPSDEAPGLSKGFYPWKGHVQGNSFFNTCPTSLGVSSGTSRSNGMTETSAFSVTATSSSCNDFSMYQTPVPPSDSVLESAHAQRTMFLTKFPSHAESITGIYQRMHPYDSWLKPVGESVSSAWWDMGPTWVDPPNPAGLSSPLSGYSSDYSSAFSPSAPQHLLPAAQHLFDDFRTPVPSPYSEPAAAAAPALTASPMVSLPANSRLSSRRHSGKATCDCPNCQEADRLGQGGSSPRRRGVHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFECSVCHKRFMRSDHLNKHVRTHTAEGSEDGGEPGLKSVNSDTDISGSGSPSQSPGAHENERAQGSETQRAGE
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQNTALDNSADSKCSKCDNKATVLTKSDAVCDSCFVRRIENKIRRQFELVRPNLQGRKSKRAMLAISGGISSMAMLETANYLSKYRDDNYRPMFDELLAVHFQWGTDSAVAKTIEESISKNYPKCPFKVIGEAELLNRTIATDSRGNIEINADNEKFNPEVISSLASRQDLLYRIRDKLLVSYARKANCDTIVFGDSGTTIAARVLELVAEGRGFAIPWYTSVCSKLPNCDTFLLRPLREVLSSDLKSYMNIKGLAFCDSLIEARPNTIHGVTESYFSSLNDTFPSLVSTVVKMSSKLHVPSTEAICTICNLPMQEDAETWLQKTTVEHPDSVEGIKNQNVCYGCSVSLKSLKGTLHIPDIEKEGI
The following text describes a protein:
Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
Subcellular Localization:
Nucleus.
Sequence:
MQNQSSTNHPGASIALSRPSFKDFQDHAEQQYIAAQQKAALQHAHAHSFGYFIIQDSAFGNLTFTVNLYHPEIFFVNS
The following text describes a protein:
Function:
Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.
Subcellular Localization:
Nucleus.
Sequence:
MGEVKPAKVENYSTGTDANTLFVDGERVLCFHGPLIYEAKVLKTKPDATPVEYYIHYAGWSKNWDEWVPENRVLKYNDDNVKRRQELARQCGERSKKDNKKGSAKAKKMEQMRNESRASTPSKDSNTSQSTASSTPTTSAGPGSKSEAGSTGTTTTNSTANSTTSRAHRKSTQSTPSTARPGTPSDKKEDPAAAETTEEEGPVAPKKKRMSEQRPSLTGSDVAEKPLPPTTTPSTPTTEPAPCVESEEAYAAKVEVKIKIPDELKHYLTDDWYAVVREHKLLELPAKVTVQQISEQYLAHKKSVKSTSASKEVAINDVLDGIVEYFNVMLGSQLLYKFERTQYADVMQKHPDTPLSELYGSFHLLRLFVRLGSMLSYSALDQQSMQNLLTHVQDFLKFLVKNSSIFFSMSNFINVDPEYVRNAQ
The following text describes a protein:
Function:
Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway. Required for the process of sporulation on senescing leaf material.
Sequence:
MPYDKKAVHFGGGNIGRGFVAEFLHNSGYEVVFVDVMDSIIEALQKQSSYTVTEIGDDGEREFTIDHYRALNSKHEMDKVVQEIASADVVTCAVGPNILKFVAEPVAKAIDARTLDYPIAVIACENAINATTTWRGFIEGKLSEDSKSNLDKKARFANSAIDRIVPVQDKDAGLNVKIEKFYEWCVEQKPFENGGKKPDVKGIHYVDDLEPYIERKLFTVNTSHATAAYYGHQAKKQYIHEVLQDKKLHDIVRDAVKETAHLIVSKHGVSVQEQNDYVDSIIKRISNPVLKDNVERVGRAPLRKLSRKERFVGPAAQLAERGEKVDALLGAIEQAYLFQNVEGDEESAELAKILKENSAEEVVTKVNGLDKSHPLFEKILPIVKKVQGGS
The following text describes a protein:
Function:
Involved in primary piRNA biogenesis in germline cells.
Subcellular Localization:
Cytoplasm. Note=Localizes to Yb bodies.
Sequence:
MEHQLDPDQEESILITHFVNPHQFSYVRCIDVENSAMLVRQIEQDLKDYCSSERTKQVYVEDERVIVRYQRWSPPKLVRGVVRRRQNEEYLVWILDYGFNLCCSVWDLWPLPDHLSRSLCDFKEGGVALIAPHSGSVWSRSAIESLDKQLEDANQLTFQVVHRGKSNRNFGLLKFRSSCQTEDAANFLIKQDQGRCKETLTMAIPYEDISFEKAEINDMAIDTRPRLRRILELVVLLSENAKESTPTPSAIQQKKLDALLQSHETYLIPNSVKLLSKVQSISESSMQTALANRSKQISKELPHKANQSEDNRKKEVKYLESENLSECLSKVKLSSYQQKNTDSSTLSGPRNLASSSTNSNSNVRKSMTLFKSSGAHLTTSLSVPLTENCTNQSNNRTVVFSMDKMEQIFNDMLGKNPSERSVQKNRSQMPNSNVSTTKRCVEKMHVCRSENMGDRKPSVCLKHLVLAHSPEPVNPVTSYKELPLGNTILNAMDDLNFQTPLPTQIYAWPHLVNRGSLVLVNPSGTGRSWSYLPVICSSVLSSFENVTSNLDTRIAPGPLAILIVDSVENAKKLASHCEFLMKDFNTQNLKVVNTHAHSMMDVYMMLLNSCGVLVTTLAHLNNILSNELPLVNPTRLEFIIFDDYDRKRLDNAELLKEVFQKVNSIGGLSKQLVLVAQQWHSERFQKLLNRTTKPLILFGDFLEAALYGGLKFNVTLRSSALKARQLLDILAEQDGSKKRTLIYCKNQMELEELSAILIEAGLQCVDISKAQNQSPNRLMLVDDSQVRKQLPVRNIQLLIHFSLPESWLRFSRRFHTMADNIRNLFTKPIGRGQDLITYILMDENNAKEWPRIMKFLQDHGLTTQSMPDSEQQLDNTLPYCPYKLSNGNCNRNQCNKRHHFLKTDLPKIGNPLLQPGTLIRCKFLKAYDPAHMAVMPMKYKSKDSTIWIDVPYPSYPSTLVFKMSFGVPRKVHNPCKINDVCFVQHKELLSRVRIVDNPARPQVTVQLMDYGTELLQVKASQLLECPEQFRDLQQLAMDIRLSGLAGSGQGGMWSTDSIQWVQDRFADINEEIMQITVDFGVLDVAYVKEIALIEECPTMLTSVYKTFLRKELLRQGFAKIDSTSILELRAIHEQWKQEMEELRANKENIVCSSTDLDNRDSKITSLQNKQATCSSGKEEDLNPVETPLIIASPNSNETLEERKHVSDKVQNKIDELNDFNKSVEIEHVQDASPLDSSTALINTLIHELNTKSPTKKKNTQEFIKNIVHEDETQSIHHEISSSTNSLKQDKTIVVGPQDPPKELFLQYLNCATKSRESVYPMVKWHQTLTHIELVVEQQMLEYKLGLDGNTLEYKVNETTPPQRFILNLLGEVRIDSVKQHGYYLHIKLTKVGLLFHWPTLLNSLYVQKHAHWLIYDSERSHGPPPSFGLVLWEGYLTHKKTKSYSDSESSEFSSTPEDFIEPGVEYCEMDSNLYED
The following text describes a protein:
Function:
Inducible lysine decarboxylase that catalyzes the proton-dependent decarboxylation of L-lysine to produce the polyamine cadaverine and carbon dioxide. Plays a role in pH homeostasis by consuming protons and neutralizing the acidic by-products of carbohydrate fermentation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEESKK
The following text describes a protein:
Function:
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
Sequence:
VVFSFFSRKNYFLKANFTQKMRVAANLTMMYTDVPLLSRFEKKLCRYVRAAADGFKLVEVALPYSEKAEDLKKAADYNGLKHVLINAVPGNWEGGQRGIAALSSEKNRFKESIDTSIHYAKTLQCKKVHVMAGVPTGSDLVSAATVFVVNIGYAAEKLRENGLECLIEPICPAAVPGYHLNSYEQAHEIMSVINAPNLFIQFDLFHAAQLANLSPMDVTKWKDSIGHIQVAQVPARGEPDTEGTVDYGEWFEWMKSSGKDWVIGCEYKPVTKSVEWVKKYGLDF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQPLSKLMAISEPRNLSLREQRQVLRADMSWQQETIPVVETHDSEASRQKFRHFQYLKVSGPHEALSQLWELCLQWLRPEIHTKKQIIELLVLEQFLAILPEEVRTWVNLQHPNNSKDMVTLIEDVIEMLEDEDMPCKDSAPQMGSIKEKMKAGSRTGKPQEPVTFKDVVVEFSKEEWGQLDSAVKNLYRNVMLENFRNLNSLRKAHLLSKPFESLKLESKKKRWIMEKEIPRNTIFDMKSISGEESSHGVIMTRLTESGHPSSDAWKGENWLYRNQKKWDINLPQEAFIPETIYTEEEDFECSENKKSFDINSISSICATQQGIPSKKGSPKCDKFKTHFKFNLDSVGKQHSEYEYRNDLSLSTDIRQQKIHTTMNSYECYQCGKAFCRSSSLIRHQIIHTGEKPYKCSECGRFFNRRTNLTKHQKLHAEAKACTSNKCGKAFSKSEDSNNPTLHFGNNFYECVNCGKSFNRSSSLIRHQMIHTGEKPFKCKECNKAFNRSSNLVKHQKLHTRDKS
The following text describes a protein:
Function:
Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MPPTQAESVIKNIIREIGQECAAHGEITSETVVAFMVKAVVLDPSNGFNMDRTLVKTDVQKLVKLCVARLLDNKNPSLDTIKMQVYFDMNYTSREDFLEEHHRVLESRLGIVSREITDTRACAKEELENLYRKIVSYVLLRSGLGSPTDIKIVREATAALQSVFPQAELCTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILLEAIPATTHHIDSQLQIAQEQAFRYTAIIEKVTNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVELMTKQLAAQLEQLKMTVKSKTAVPTSQVFPIFIALASLWTSFQDETVLISVLSNLTTNLELFLGTHDLLFPEKVMQGLLDGVIVKTDMTRIEEHLEEKVQLADFRVLEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPTIGILKYKEKYYTFNSRDAAYSFAENPDHYINLIKEKAKKNAELIQLLELHQQFETLIPYSQMKDVDKHFIKPITKCENGTQTDTHILPPTIVRSYEWNEWELRRKAIQLANLRQKMTHSVQTDLSHMRRDNASQVYPLKEVGTQSKREGSTRVPRPQIFIAGLRGGQSKTTHGVKINLTRAVDET
The following text describes a protein:
Function:
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Plays a role in mesoderm formation and may be required for neural development.
Subcellular Localization:
Secreted.
Sequence:
MHLYFYCLILLFVPGGNSLGINSYLKHMSNKPQDHVNRTKTVDSKDLAALPLSSYMLNLYQSFHHSELNHGTEGAPSLPSNHRADIIRSLAAKSFDHGGSRWTLVFDFSSLSQEEEHQLAEVRFDFRAFEGAISAEMEVMVDFLHQSSSCQSISGWCQSYLYVGSLTGTLRSRSSDTWVTFEATDIIHKWFERNEKGKSRYEDREKQLKKLPRAKSAERRYQQQNTEDQQIVMMVYSNISKKERLSGTATLLQDAAHSKYLVVMPGIQTIAHTRRHRRSHIFKEHVMGMKHVPPADSSRTLCRRVDFFVDFKQIGWDSWIIHPMKYNAYRCEGECPSPVNESVKPNNHAYMQSLLNYYVKGKAPEVCCVPIRMSSLSMVYYDHDDIAFQNHEGMIVEECGCQ
The following text describes a protein:
Function:
Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex. Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex. Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer. In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLPQCPSPWPQVPLLQAAVTILRLSDGSADPSSSAGGRLCGALGGCVRVQRAALDFLGTLSLGTSPLELVLEVFAVLLKTLESPESSPMVLKKAFQATLRWLQSPHKTPSGSDLSPDALLFLGELFPILQKRLCSPCWEVRDSALEFLTHLIRDWGGQADFREALHSSEVPTLARQLLQDPESYVRASAVGAAGQLSSQGLQATPANQQGLLMDLMHILSTDSEGFPRRAVLRVFTEWLRDGHADVVRDTEWFVATVLQAVSRDLDWEVRVQGLELAQVFLIQAMGQPRLHCPYTVGLPGATSSRPHLEFLQTLCRLPLFEFAFCALLDCDRPVAQKACDLLLFLRDKTVSCSNPQEAGDSPNSASVEAALQRWREGEQAQPLGDLEPEAMLAILRSLDLEGLQGRLAKSSDHVEKSPQSLLQDMLATVGVLEENEADCY
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MEEEAKEQQIARKKVAVLPWMRSPVDVSSFENCPLTQLPFLNPRLEAALCNSGIDSLFPVQVAVWQETMGPGSFERDLCVNSPTGSGKTLAYALPIVQTLSSRSVKCLRALVVLPTRDLALQVRDVFATIAPAVGLSVGLAVGQSSISEEISMLIERPKLEAGICYDPHHHPIELQSAVDILVATPGRLIDHINNTKGFTLEHLRFLVVDETDRLLRESYQSWLPMVLQCTNSTVDAFFSNPSTFGSLKTVRRIGVERGFKNKAYPRLMKMVLSATLTQDPTKLSQLQLHHPLFLTTGHIRYKLPEHLHSFKLICEQQMKPLYLVSLLKNLQGEKCIVFTSSVESTHRLCTLLKFFGDLGIKIKEYSGHQHQTLRSKTLRAFREGGVQVVVSSDAMTRGMDVEGVRNVINYDKPPYIKTYIHRAGRTARAGNSGRCFTLLHQDEVKQFKKLLKKADIDSCPVHTLPSDSIESLRSTYDAALEKLKENVEMEAFKKRKLGFKSSSKMKKR
The following text describes a protein:
Function:
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Subcellular Localization:
Mitochondrion.
Sequence:
MSCSCTKRTLQLFIRNVAQVELAASSTSTYPPQRTNFQRFNVPSLPSLHPSHSRAYWSAYSSEPRRDTVEDAPIENQEGPPSATEGHINTTPEKIDDMDDLFMEITPESLDALAAETSSGLANSQSRESKELKQPWQAEKSRKFIDPEETTEETWTQGEPIDIFSKPMKKPRWDKPVESLRFRSIKIDNAVAVPYSPQASTSKRNMVRDDWTPPDRKTWMEQKAALKEKFPEGWKPMKKLSPEAQAGIRALHAQYPEQYSTPALADRFQVSPEAIRRILRTKWVPKPEEEADRERRWFQRGKSVWGRYAELGVKPPKRWREEGIGRGKPEWKKRAAPVLTTSRPGTSEPRRPETISLDDQMEDRIF