lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Subcellular Localization:
Secreted.
Sequence:
MVREELAGVAFLPCVFTLRPSPSHEPPRIKWTKMLSGREQSVLVAKDNVIKVKKDFQGRVTLPGYPDNRYNATLALTGLRSSDSGLYRCEVVVGIDDEQDTVPLEVTGVVFHYRAPSDRYALSFRDAQRVCLENSAAIATPSQLQATFDDGYDNCDAGWLSDQTVRYPIRSPRPGCYGDREDQPGVRNYGDRDPAELYDVYCFSRQMKAGEVFHTAVPEKLSLATASTHCHSLGMQLATVGQLYLAWQDGLDRCDPGWLADGSVRYPINHPRRNCGGDEPGVRTVYQNPNRTGFPDTTSLFDAYCYSGTLFPSLPGSESGVWICTPEKVFVLNAPSELSSLASNDSAEMSGEHVVMHVGPSSLRLREPAEQNAEGPPGTRPQAASPGPAPEGEPSLESLEQQGGSAREEEGAEEEVEGGTREPAQSTISPGKGPAAEPTGEAIDGDSKPETSHFTTQNAILEHISVKPSHGASAGDGLTGSNKEISDQERETFFESSNSNAAAERDQADDRGWPAGHAYTVEEHNKAGSGEMGMVLLCGKALLNAFSCSLQTVAHSRAVPARPPCYCRVWELSRLHSRFLFITVQTHKDLTSTVTVAPLNLEGRQSGQSTLHPVEEKETLHDRYVTEAGPHPPVVATTPSTWATSLSFVPIEPLATIRTATAEAYASDVPLATQKQLLQTDGAQGRLSSQTTHGPVVRQSPAQSGLSAPTGGPSEDLDEPTELPAVSVTRSPEKMTQGEVDSNHTEESPPLWSDRPESSSFSEPPAVAGLDFKDSVGEAITHSVFFDYTPVVQAGKPTLDASPVEKSAGPEDRPSMVAATTDGPPSATSQSQVLTSALMESHQSSHTWYNEEEEKNTTTPGPDFSPSTAMSGLTASTGAAKNKRQIGVPLNTGEPLNYLRANKGQTDQKRDRCSSGSGELVCVLSSPPLLPLLPCSSAPSIPRGFGIYLEIHLQVIERHLFIYFFFFPPYSPLCSAFWHRAPALTPACAASQIETLTRLLHQAPMKELFPPRPASATLPGKERSATAGKSRTASPHYVTHMLYSSRWRITASSSPNPIPGVSNLASKSSLVPPHHLASLSPPSRACALAHVSSGTGHVCRVPPAAENDPCQTNPCLHGGTCLSTGDLYSCQCQPGYSGENCEIDIDDCQSTPCQNGGTCIDEINSFVCLCLPSYGGATCEKDTEGCEHNWRKFHGHCYRYFTHRHTWEDAEKDCREHNGHLASIHTPEEQDFVNGLGRENAWIGLNDRTVEEDFQWTDTMAVQYENWRENQPDNFFAGGEDCVVMIAHEHGKWNDVPCNYNLPYICKKGTVLCGAPPTVENAFLIGRKRTHYDIHSVVRYQCADGFLQRHVPTARCRSNGRWDHPKIIC
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Sequence:
MIKEGFLIKTPKKLIALLGPSGSGKSALSIELAQELDAEIFSLDSLSIYKDINIASAKPSLKERKNIKHYALDHLNIDEKNNAPLFKTLLEDAMRVSSKEILLIVGGSSFYLKSILEGLSRMPKLSGEEVVKIEREIATLSNPYIFLKSIDPNMAFKIHPNDTYRTHKALEIFYATCTPPSEYFKANPKKPFEHAISLFALSIEKSALHNNIKRRTKNMLHSGLVEEIKALYTQYPKDSQPFKAIGVKESVLFLEKRLTLKELEEAITSNTMKLAKRQNTFNKTQFNNLYVGSAEEVRHAILKHSKSGIKG
The following text describes a protein:
Function:
Catalyzes the non-oxidative deamination of L-tyrosine. Has very low phenylalanine ammonia-lyase activity (in vitro).
Sequence:
MLAMSPPKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGASGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MNKGLCGRKHLPVHPSIPEAEESTQRRNCDVMKRSSLISGLQLKFAQRSWNDTLLLVQRCMEKSRIESKPCEPLVRSLERLQDVLHAPCRSVTRSRLEMIAQQQGMGFHVTEDTCYLTADLFYLEVLLPPCGGVQEVKVALHGEGPVPSESFLKTLRSEDFAAFSTRLKDLFTQYNIPGDNEIKLKLLESLQFLVRDLQKMTGEAEDCDPQQQLVNNNRTGCLVAGKEDGLLTVLFYKPPNDGMSNSLMQTAQVTVGASAVPRRLQMASVLPEPLQLDSQGCPVGAPPSEVPGEMLPACFLLRLKPPVPVLSSFVEKLSLITDVAVAQTDQQWAPLHRLLMAGSQSAEETSDQLDLFTVKVLPDGETQRYVFPGASWDAPEQRATVVEAVSFTHPAQVPALLQLLRHQCAVNALLRSCWASQSAAPASPTGTPSDSQLFEVRPESSTSFSVTFTHPRTHSLAVLLVSVCGPQQITCRTFGAETSEAFLEDHMKNFLSIPATMKMLLSRLETASPPHPKSHPTSAEEDPPALMEVSQNAAVPEDSVSKTEVSPNPSVTSHLCSPVGTFAQQAEL
The following text describes a protein:
Function:
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development.
Sequence:
MIQCCRTLLTLSSSNLVRIVCNFAMAGDDARNRMVWVDLEMTGLDVNKDHILEMACLVTDGNLNVIAQEEDLVIHQSDEVLNNMNEWCIEQHGRSGLTESVRKSMITLTQAEDIMLKFIQKHAPYKVCPLAGNTIHADKRFLDHYMPRFMDHLHYRIVDVSSIKELSKRWYPNVLPPPKGSSHRALEDILESIAELKFYRKTLFV
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSFAKAAKAQRRAHRERAQPLHRSKFGLLEKDKDWKTRRDDYKSKQKRLRALAIKARERNPDEFYFSMVKQQTKNGRHVLKDDELEHLTAEQLQVYRSQDLGYVGMRLTQEKRQIERLQSDLHMLVNSQGSGHGKHTVFVDSKQQLKSFDAAKHFDTPRELLDRPFNRLHTKQLQETELVMPEARARKKMNRARSRAYEELAERKDRVTKIAKVANTLQLQKNLAEKGARTKVKGGKGKAPVYKWKQQRKR
The following text describes a protein:
Function:
Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation.
Subcellular Localization:
Chromosome, centromere. Cytoplasmic vesicle, autophagosome. Early endosome. Endoplasmic reticulum. Late endosome. Lysosome. Midbody.
Sequence:
MSSCASLGGPVPLPPPGPSAALTPGAPTRALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCDNEKICKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKEEAYQLLIEWKVYLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKAHPNAQKNLLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQRIGKEIEEKLRLTSTSNELKKESECLRLKILVLRNELERQKKALGREVAFLHKQQMALQDKGSAFAAEHAKLQLQKESLRELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHISSAIPVPKRQSSTFRGADVGLSTGVPSPDNVHRKRASSENERLQYKTPPPSYNSALTQHGVAMPTLGDSERKVTPLSSSLDTSLDFSKESKKTGVDLGNSVSGDHRNVDSSQEQGEALPGHLATINGTALPSEQPGPAGTLLPGLCHPAPSAELCCAVEQAEEIIGLEATGFTSGDQLEALSCIPVDSAVAVECDEQVLGEFEEFSRRIYALSENVSSFRRPRRSSDK
The following text describes a protein:
Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Sequence:
MSLVNAAPNSSVDSFPKKKPLIGKHFTLLQPYVRVERLDQETLRRLLPVRKAVEDQSESSKESVEKNESECSAEEFAEENESEASEESVEEIETPVKKNKTSERKMNAKANYEMSEYEKQIQRNMEENEKMFQQFVGGAKENFMKVVPKKNYNNVEVTKKKKRRWYNDVNEQEQEFRALKRLYRQKDMNKRDLTSNSRSLRARKTPLPIQNYNELLGGPSEESSEESSEGSSDISNEYERPVYRRKTEVDEATEIPSQRNYIIKEWRKRMDLVTLADAKLKHKSIVDSKFIKEMIHLLEKEGELEELPVDQPDFLKLMKSFSIHEKGVAKISQTDIKCLAWHPSNYKLLVAVGDRYGNIGLWDIDKLDDKYQGVRAFDKVHTMPINCITFDTSNRMRLITSGDDYCLRSLDLHSNVCEKIFHSSSSRITDHAQKNRSTLIVAHKNAVVIDTRTGSCRIENTIQCFENITYTVSLHPQDENLFIACGRTGEIGIFDMRYTATNAVAVPVVSFPKASKRINGASFSPITGNFALTTGADDTITLYDVQKGKSETECIKSIHHNNYVGRFLAPFTANWHPQREDVFIVGSGEDPSRVELYGAPSCELLHTFEGDVLDSMTSLATFHPTLPVFASCNLSQVHIFRP
The following text describes a protein:
Function:
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MCTGGCARCLGGTLIPLAFFGFLANILLFFPGGKVIDDNDHLSQEIWFFGGILGSGVLMIFPALVFLGLKNNDCCGCCGNEGCGKRFAMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFSILLVVGGIQMVLCAIQVVNGLLGTLCGDCQCCGCCGGDGPV
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MQMQLKDLCLNCVNEAEIQEKRVNSAKHKLSQLLESCKTAADSSVETLVKIGKLKERLRELEDGLDLAEAKKANRNSQCESITESISAAKARNEELKNIIQNQRAKKDEYATIISRVLLASETLEEMNDQNISYRKGQEGAVQWYNRFLGFRIEAGHGIKFIFNKVDPRNPEKEFSFTVRHWQDKYYLQDCDPNLEGTDDLLRELNQTNCLFKFVRVMREKFRMAALLGNSDIHESTPRLEQSSVSISFFHGRSKDDSVQQLEGPEQPSKRFLDTTPKRVPRSHGSHLVSPSPEPESAYVKEAALRASNRTLST
The following text describes a protein:
Function:
Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal; KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules; KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MAAFRTTAWRLISGVLGVICLVLMAALGVLLKNSLTKRSVQPGPSADLQEEYNLHEEEESCLGCLGSGCYSCQEKWIGYQCNCYFISNELKTWKDGRDFCVSHNSSLLQIQTRNEPAFMKFSTSFYWIGLSYDEEHHAWLWEDNSTLSQDLLPFFKSVNPKNCIMYNPRGRILDAYCEKKFRYICKQQLI
The following text describes a protein:
Function:
Putative oxidoreductase.
Subcellular Localization:
Secreted.
Sequence:
MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPSPQSSPDLSKMTHRIQAKVEPEIQLS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVNKSTTNGVSDPNLENKRTKVTLTNSGVENARGTYYSGAYTSVGYDNSFNLNRFKENFKINILSESANELVFEMIGIDAPIANALRRIMISEIPTMAIEKVYIINNTSILQDEVLAHRLGMIPIKVDPRKFNFKLPNKEYTAEDTLIFQLKVKCEKDSVTGKIINETALSKHLIWVPTQDQEEMFPNEEDRPRPMEDDIPIMKLRPGQVIDIQCYCEKNIGREHIKWSPVCTASYRLQPVISVDKSIKGDKANQLLEKCPKKVFDIEDSGQVVAARPLDCTMCRECIRDPEFEQNVKIERVRDHFIFSIESTGALKSREIFQEAIKIFIEKCNIVEESINKLVN
The following text describes a protein:
Function:
May bind RNA.
Sequence:
MPAIDVGETSGEKTSRTWPYSPENIPQYPICITFSRCLSQRSRFAPAALFQPSFGEEAAGARSLTHFQALQQRNREEDALRDMGLSDAERRLWRGNRGGEEQEEQSPGLGATPEARQDRLRAIQEKIAERQRILALPQRFAGSKPLSRREMEIERSLFQGTDRHAFLRGLYHQGEAPQKDSSATEGPAARLETLYQEVLAPAPPREPLPEPPTHGTDPAPHPETTALVTRPVTFIPEEEICQSRLSEEEIRQIPRFASYDPGEPSQVLYLKNLSRQVTVEDLMSVFARFQEKEGPQIRFRLLSGRMRGQAFLTFPSISVAQAALQLASGYHLLGKPLVIEFGKSKGRPEPIPSPGTPAPPSEEENLTSVDVAENSKKHRTGSTIASREGIVFSGERPDVGQPS
The following text describes a protein:
Function:
Malonylransferase involved in the biosynthesis of curare monoterpene indole alkaloids (MIAs), natural products such as strychnine, a neurotoxic compound used as a pesticide to control rodents, and its pharmacologically active derivatives, including brucine, used to regulate blood pressure. Curare alkaloids act as animal glycine receptor antagonists. Catalyzes the conversion of 17,18-epoxy-17-hydroxycur-19-ene (Wieland-Gumlich aldehyde) to prestrychnine, which is spontaneously converted into strychnine and isostrychnine.
Subcellular Localization:
Cytoplasm.
Sequence:
MNRIGSLYFNTKFVKSKVCNSTYKAFPLIINHHTMASFQIQIISETLIKPSSPTPPSLKQHRFSDYDKTMHHMYIPAAFLYTSHGHGITSTDEVSQLLKNSLSKTLSHYYHFAGRLVGDSHVDCNDMGVKLFEVRVRCPMTEVLKRPNTDAKDLVFPKGLPWSMGEGDILVVAQITYFDCGGIAISTDMSHKIVDVSSIATFMKDWAAMARNSSHQPYPVIVSPTILPMDDIPATAEDDIMKENICQSRRFLFDDSKIVELKAMAANSGVENPTRVEVVTAILHKCAVTASTTALGSFMPNILLLAVNLRSIVSPPLANTSIGNISSCCAISVTHENQMKFPLLVGELRRSKTKLLQNYGKQLKKSELLFLNGTDKAQKLSDGDSFDCFIFTSWCRSPLYEVDFGWGRPVQVYVPSCPIKNTFRLTDTPAQDGIQALVTLEENVMPIFENDEELLAFASLIKDS
The following text describes a protein:
Function:
Key maternal determinant of the dorsal organizer and body axis formation in vertebrates that acts by promoting stabilization of beta-catenin (ctnnb1). Localizes on the plasma membrane of the future dorsal blastomeres in early blastulas and binds to and promotes the tankyrase-mediated degradation of axin (axin1 and axin2). Axin degradation results in stabilization and nuclear translocation of beta-catenin (ctnnb1) for activating organizer-specific target gene expression (By similarity).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Enriched on the plasma membrane of blastomeres only in a small region in which the dorsal organizer will form.
Sequence:
MVTLSPAYLPSDGGTQAASAAPSVEENWVVQPSLTLLVLLLVPCVLLLFFLNCFLLFHRLPAFSLRKRASRRKVGQYPCVRVGHSGQARLEPPYMLSPGVVLREGRLGSDTISQGFEATLALEEGVCGRQNTPQSRGSCCQGGSIPSDQICCSPRPRCATPLPCCAPRRAWNAPAYVKKRLRPKVWKVREDELGSSCELDTRHNHVPPNTPAADNALGVTPKVKFCHTSSTQRKSHVGMVPFTLGGSELLEDPSVIPREDTAEHLDASSSLPGPGLDSDFGVSAGISLHILSSDSDSGSQSWTSGMEWDYYDPCYMRRNRLRRDARHNRHLPMMCSKQYWI
The following text describes a protein:
Function:
Together with methyltransferase TRM7, methylates the 2'-O-ribose of nucleotides at position 34 of the anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Also plays a role in the regulation of the retromer complex and is required for the recycling of plasma membrane proteins like CAN1 and MUP1 from endosomes. Involved in regulation of Ty1 transposition.
Miscellaneous:
MISCELLANEOUS: Present with 3450 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endosome. Note=Recruited to endosomes in cells in which increased recycling of internalized plasma membrane proteins occurs.
Sequence:
MKDLSHYGPALCVKFYNDYVLAGYGPFIHVYDYHSATLINKCRLFHYNKVHGLSLSSEGKILAYGARSVTIVELEDVLKKESLVDFERINSDWITGATFSFDNLQIYLLTCYNKVLICDLNCEVLFRKSLGGERSILYSGIIKVFGPDKVYVNAGTVMGGVIIWDLFSETKIHNLLGHEGSIFYVNLSNNGRYVASCSDDRSIRLWDLETGKQLSVGWSHTARIWNLMFFDNDSKLISVSEDCTCRVWNIIESRENVAELSISNVYEVHLIKSIWGVDVKDDEMIAVTSGNDGRLKLIDLLQLKRHGDEETSFSLDDIAKQCGDIFEKNESIKGFQWFSFGVIAITSLGKILKYSDVTKQWKLLLTNEKFNSYPITNGIQTQNIAVFSNNKSDILLIKFSKDSADIIETEEFHLDELSKTNNCLVTEYDDDSFLLTLQSPNPREKFVCLEISLQNLKIKSKHCFNKPENFSSSCLTSFRNHILVGSRFSTLVIYNLLDESEEPFIIRRLSPGDTTTSIEFVEDKDNSAVFSVTNRDGYYVFIELTKNSLEEGPYRLSYKVLHSNKMMKGFLEGAFFNSKGEYITYGFKSSLFYLYNETNCYELASEVCGGSHRLWNLAKITDGHVLMYIKASRFHLRKIYNSIVPETLENGVHGREIRDISICPVSNTNTNDNFKDGHIFCTASEDTTIKLGYFNNRTGKVQNFWTQRKHVSGLQRCQFINHKLMISSSAREELFLWELNDKYNKRPYMTIRQALPVSTNNSDLRIMDFDVKFISQSGDFLLVTVYSDSTIKIWHYRENQNKFDLIMQGRYKTCCLFNVVFIALKEELLVVISPTDGHLVVYNITEYVPFSVDPISGDLVDHKLDATISNLPAPVAQLPVHQSGVKSLDYVANATRTSATILTGGDDNGLGLSNLKLDDSNKVTLKTSDFIAAAASSTITSGMLINGGKEVITTSVDQVIRAWEITAGKLSLVDKKRTTVADTGSLEIISNDEDADSEKTLLIGGVGLSIWKK
The following text describes a protein:
Function:
Ferric-siderophore reductase involved in iron removal from the siderophores after their transport into the cell (Probable). Involved in intracellular removal of iron from iron-vibriobactin complex. Vibriobactin is an iron-chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm (By similarity). Ferric-vibriobactin reductase catalyzing the reduction of Fe(3+)-vibriobactin, a catecholate siderophore synthesized by V.cholerae (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSNEVERVYPRLLDFVRKKYVSKNLLRVTLTGEDLIGFPEDQNGSHIKVFFPNQASGILQLPIREGDKVIWPEHKPVPRAYTVRQYRAQSNELDIDFVVHGEGTPGGGWALKAQTGSQLGLIGPGGPDPLIEPADWHIMAGDLSAVPAISAILEKMPSQAKGYVFLEVDDIEDKHDISHPEQMVIKWLVRDPNQAQPVLAMAIEQLPVPQGAESLSAFVAGENESVIACRKILRNEYRIARDKIYAIPYWKRGKNEEAYHEERHVVMDEEF
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTKLFEWFMAAACFFSVYFAIVLRQVKHPLLDEYMLEIQLSPLFLVLLFGIFSATVVLYRTFTFNNCEEAAKELMEQIKEAKADLRSKGLVLSD
The following text describes a protein:
Function:
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTDVPATFTQAECNGDKPPENGQQTITKISEELTDVDSPLPHYRVEPSLEGAPTKGSQEERRKLQGNMLLNSSMEDKILKENPEEKLFIVHKAITDLSLQETSADEMTFREGHQWEKIPLSGSNREIRRQKERITEQPLKEEEDEDRKNKGHQAAEIEWLGFRKPSQADMLHSKHDEEQKVWDEEIDDDDDDDNCNNDEDEVQVIEFKKKHEEVSQFKEEGDASEDSPLSSASSQAVTPDEQPTLGKKSDISRNAYSRYNTISYRKIRKGNTKQRIDEFESMMHL
The following text describes a protein:
Function:
Initiates the restart of stalled replication forks, which reloads the replicative helicase on sites other than the origin of replication. Recognizes and binds to abandoned replication forks and remodels them to uncover a helicase loading site. Promotes assembly of the primosome at these replication forks.
Sequence:
MKASKVVLFDTYIPEKDFLYYSIPDEFISLVDIGKAVIVPLKKSKKLGYIWDIVEIEDPKFEVYPILSVLENIPPISKSLITLVNWISNYYSNSLYKTANYIFPSGVELEIDRYLKAKDVAVDMSKKQEKVFLALVESEIEEKKLKKELKISENIIKSLLKKGAIEERFEIKLKEKKPRKHVYLSEKKGDSWGSFLIERKILDLMQKPLLLFVEAREERWKIYHEIMKHIYQKGKSVLFVFPTIKSLIQFGDFLSQYVPFSIYFYHSFLTEAQAYSVFKTTNTEQSVVLSTSKGLFLPFKDLGLIIVDQEENEFYNMREKEPRYDTVVVALKRAQLEGIPIVLGSSSPSIASFYRAINYKDLELYRKPLLNRPQITVVDLRREKTHDILDFYSLRKTEENLKNKKKVFILLNRLGYSPYVQCQDCGYIFMCPHCKSSLVYHLEERIMKCHYCGFEMLPPERCPVCEGYSFIQSGIGTEKLYRYIVNTYRWAKVLRVDSEIELQDETLIHEADIIVGTRLIEPWLDDNGIGLLIIYNLDNFLHIPDFASPEKTFNMMKRIVGMYKGKEIIIRTYNPSHYVVKALKINSFGDFLNRELSNRKSLNYPPFSKIHQILLEDIDEREILEEGGRIVEEIRSNFVTLDVLGPAPYFPYFIRDKYRYQIIIKDKEGLIDGAFLRGICEKSKAPFSNLRFIINIDMEEILT
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MPIQAVCCMSGTEGVKGTIKFVQEAEGKPCKITGTIEGLKAGNHGFHIHVYGDNTNGCVSAGPHFNPFKKEHGGPSDENRHVGDLGNVVAGDDGKACIDMTDALVTLVGEHSVVGRSVVVHADEDDLGRGGHEDSKTTGHAGGRLACGVIGITQAS
The following text describes a protein:
Function:
Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVIGLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIGFSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANVLLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNILEKKYAHYV
The following text describes a protein:
Function:
Seed storage protein.
Sequence:
MGSSSLLSFSLCLLLLCHLSQAQFGSSQESPFQSPRRSVSSRNECRIERLNALEPTRTVRSEAGVTDYFDEDNEQFRCAGVSTIRRVIEPRGLLLPSMSNAPRLVYIVQGRGIVGLVMPGCPETFQSFQRSEREEGERHRWSRDEHQKVYQFQEGDVLAVPNGFAYWCYNNGENPVVAITVLDTSNDANQLDRSHRQFLLAGRQEQGRQRYGREGSIKENILRGFSTELLAAAFGVNMELARKLQCRDDTRGEIVRAENGLQVLRPSGMEEEEREEGRSINGFEETYCSMKIKQNIGDPRRADVFNPRGGRITTLNSEKLPILRFIQMSAERVVLYRNAMVSPHWNINAHSIMYCTGGRGRVEVADDRGETVFDGELRQGQLLIVPQNFAMLERAGSEGFQLVSIKTSDRAMVSTIVGKTSALRGMPVEVLMNSYRLSRDEARRVKLTRGDEVAIFTPRRESRAEA
The following text describes a protein:
Function:
Plays a role in chemotaxis and seems to be involved in polarization.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Localized to the microtubule network.
Sequence:
MDDDYKLIGQIGEGSFGKVYKYRKKFTGQLVACKVISKKGKNEEDILSLRQEIDILKNLSHPNIIQFISCFENKNEFTLVTEYADGDLSQIISEEKTLSVDLIQSICYQLVIALNYLHYKKVIHRDIKPQNILITSGGQIKVCDFGFAKTISSNSILLTSLKGTPLYLAPEIIQEQPYDYKADLWSLGIILYQILVGSPPFSANSLADLVHMTLESNIEIPKELNKYPDLVSLFRQLLCKNPDKRIGWPDLLYHPFVKSYNGAHVINNNNLNYNNNNNNNNNNNNNNNNGNRPITSAGGNYLNDNSSSPSISSPIQSLPLISADSLINSLNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGNINTNGYYQPLQSPTSQNFVNGIPIPILNGISNPFSVYNNNNNMNNNNNNKFNPTSPKHHQTLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQIPPPQSPKTPKVLSPKAVGISIQQQQQQQSQQQQMQQQQQQQQQQQQQQQQQQIPPQSPKVPQSPRVAPPPQSPRVLSSPRIAHSPKNSPRQTNPTSPSPSPRRNSLKSQQTPSLTNLNQALVNPSSSSSSLNSSIPTSSSTNKQIPPLSSNLNQVNLSNNINDNNNIINNNSNNNSNNINNNINNNNNNNSNNINNNINNNINNINNNNNNNSNINNINNINNNNNINSSNNNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINSSNNNINNINNSNNNINNSNNNININNSNNNINGNRPTSGGNNDLILNNMLMNNISLSSSIESIASNNNSILVQQQLQQQQQQIQQQQQQIQLLQQQQQIQIQQQQQIQQQQQLQIQLMQQQQQLNIIQQQNSVVQNGMVVSVLNKKAPPTPITRPQTPTSFRPQTPQYRTCTPRTPQPINTPASRNNFQSNVLPSWPNLYYQQLNVNDPHQLQQLQQQQQQLQLQQQQQQQQQQQLPLSSSQQQIHYYNQMNHNGNSQNERLDEISEASESLESLEFWRFHESISFKSEENASKLRSDKQFLHKIISHLSASSFSMIERLPIGLILRTFSNIMKYGTLTIQSSNNTTLQSTRTPPQTPPLYPSFNNNGNNSNNNNNSNNSGGGNNSSEIYKFSNFQILVNVLSNILATTLHITNGNGNSGIIGSTSSNGMVLLNNPYTNLLDCLNTITMFLETFQPSLSVLFNVNGLNERHGSSSTPNQSSPCPTSPNGGSSNISINNINGGKRIHSQPQQSNQTQQINTQLMFLSILNHLTKNIFIYNQGIQIAVIKIISRLFSRLGENPYLFGEIYRKIIEQTDILQNICSYFLLLLNQSYQSSSSSTISNTSSLSSSSTSPPTSSSSSTSSSTTTPLSSSTTTAATATATTSAATTSTATNSSQQQQQQPIPSSIEVEVEIVLQCFHNILYTSPQHAFEFPLEPKRNYQTNTSIQTYLMNYYQACVIIGDGLSSEIIINLLLCSISSYPHLRKIILQLSLHCLRGSKLFAESISKEEKSLIYPINQNNNNNNNNNNNNQNKNNNNSNSNPSTPNLQFQNSYNSPYNTINNNKPRSFFDYLSIKNINQSNNNNNNNNNNNNNNNNNNNNNLNTESTIEFNQEQKSLVLLILSAILIHSKESIDWMIHYDLVDLSIRYFQNTDIRISSSASYFLSGFLTVSINYEKEFDNFNNNLNNSNNNLIRPTSPNSNNLIINGTNSLIDNQLTIIIDSIIQVIPIKNIRKLFSAKRVEGNTMRDLEGGCFGKPNIGMLDGVVCILLRMLKRGGQEFLETMLESGIWEALCHQISSTTSEIELSPHGIIHSLRVIYEVLSSDTDHIPYLVKNNLLTSLCNLLDSGHLERIKEWPSLQMGSVSGISALANQIFFILYLPLSSNAKDRIGDPMIELIRHIMLAQELVRNIIMLLPQIPSDSIDLPLGLLSNIILEDSKFANQFIEFGGLEPNTAQLILNPDRISPSTLVDSLIIFSQLARISQDNYKAMHRSDLYGLLKKLLAHPEATVRAKTCNLIGNMFKYNGYFYQHFQKSGILPILISRCIDVDLNTRKFACFALGNAAFHSSDLYDELDDSIPILKKLLNNEYPFSGQQQQQQSQQQQQSQQQQQNDLLLQIEEDEKTRSNVIGALGNLVRNSSQLCQKMIDSGILDALTSYLDEYKSHTNILKSVLFSLGNFSVYEQCRYILIEDYDLDSTLDDLFEYLKQNQQQIDPTIIKYINRIKKILRSPST
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
EFDRFEMQYRDQFHKWAISLSSNQSILLYGLGSKRSVLDDFGASLSSEGDVISLNGYDTDIDMGEFIGLMEQLFVDNDSGQTNALVGTEVESLHRDSGKGLTKRASHVAKNFAATRSRPLFLLIHNIDGASLRNRFAQDALATLTSDSKRDGTQLIRVVASVDNVNVAMFLWDPIIQHKFDWSLKRVHTHRAYFEEIRHGPRTESTKKARKIHIERASVVAVAKVLESLAPRHAEVVQLLATLQRSRNSEPVSFATLKSQCASKMLTSSDSQLRNMLKELSDHGIVSV