lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Aminotransferase; part of the gene cluster that mediates the biosynthesis of terrequinone A, an antitumor agent. The first step in the biosynthetic pathway for terrequinone A is formation of indole pyruvic acid (IPA) from L-tryptophan by the aminotransferase tdiD. The nonribosomal peptide synthase tdiA then immediately converts unstable IPA to didemethylasterriquinone D (DDAQ D), via condensation of 2 IPA molecules. The symmetric connectivity of the 2 IPA molecules is thought to arise by head-to-tail dual Claisen condensations facilitated by the TE domain. TdiB then catalyzes reverse prenylation by transferring dimethylallyl diphosphate to carbon atom 2' of DDAQ D, to yield asterriquinone C-1. Finally, tdiC and tdiE enzymes robustly convert asterriquinone C-1 to terrequinone A via a transformation involving regular prenylation at carbon atom 5, which requires elimination of the hydroxy group on C-5.
Sequence:
MGSIGANNAVADPTPLFSSRVQKWEPGAIRSLLPLEALPGMISLVAGKPSPETFPIAEIAISLKDTPAGTGRIVVDGDELNQALQYGLPRGNAQLIQWFESLQRSVHGLDENGGWSCCIGNGSQELIHRVIQVFTDPGDPVLLETPAYPGVAGFLRADGQELIPVYSDAQGLNPASLEQALSEWPGDSPRPKVLYTTPTGSNPTGQSCTESRKAEILRLAKRFNFIILEDDAYYYLNYGDDKQRARSYLALERDVNGESGRVVRFDSLSKIVSPGMRLGILTAQAAVVDKVVRITENINLQPSSTTQLLALSLLRHWGQAGFLKHCAEAAEVYRRRRDVFVSAAERHLQGRATWVVPTAGMFVWLELKLPPEMDSFELLKSQGMKNGVLAIPGVAFMPGNEQTCYIRVSFSLVPERDMDEACRRIAGLVDRCACHS
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEYMHHIQGVVVLNDSGNRVFVKYYLNEDMKARGVLTTLEKQRALERVIYDAVSAPKRNWAASKDGDIVLHDVHSILFHVWGSITFAIVGDIKENEMVMHTVLRCIVDALQRILKTQDITHKGILEKYDALVLAVDEVIDDGIVLETSAQNVADDVAPFMADAETDTARSALSKVNEYLKENL
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIEDYDKSTELVTDSHFFKHAIRWDSLFYMEIMENDYRYFKNHAFGYGIVLLGKLFSNSLICILILQKICNAISTELIYKISMHYSNNNHKFSQLSALLFIFTPASVFFNSLYTESFFAFLVLVAIYLQIKQKTYLSSIIFALSIHLRSNGMFFILYSGYPYLVKAIILLKDKKFKQVVSTALEAIPIALIYLVSIGVMLYLPYKNYCQQNEMEWCKSIIPYAYGYIQKNFWDVSFLSSYKLRKLFFIYWGIQGILIQGFWLYKWMTKSCTIKNNIQGISIILPTIILFIITTFIAHVNCSTRFFSTQIPFYWCLADLFYKKDGKINKWVLFYILEFNLGGLILFTNYLLWA
The following text describes a protein:
Function:
Diarrheal toxin that hydrolyzes gelatin, azocoll, actin, tropomyosin, and fibrinogen.
Subcellular Localization:
Secreted.
Sequence:
MFILNFNKMKNVKLLLMLGTAALLAACSNEADSLTTSIDAPVTASIDLQSVSYTDLATQLNDVSDFGKMIILKDNGFNRQVHVSMDKRTKIQLDNENVRLFNGRDKDSTSFILGDEFAVLRFYRNGESISYIAYKEAQMMNEIAEFYAAPFKKTRAINEKEAFECIYDSRTRSAGKDIVSVKINIDKAKKILNLPECDYINDYIKTPQVPHGITESQTRAVPSEPKTVYVICLRENGSTIYPNEVSAQMQDAANSVYAVHGLKRYVNFHFVLYTTEYSCPSGDAKEGLEGFTASLKSNPKAEGYDDQIYFLIRWGTWDNKILGMSWFNSYNVNTASDFEASGMSTTQLMYPGVMAHELGHILGAEHTDNSKDLMYATFTGYLSHLSEKNMDIIAKNLGWEAADGD
The following text describes a protein:
Function:
May act as a transcriptional regulator of a number of proteins of the circadian clock.
Subcellular Localization:
Nucleus.
Sequence:
MQLTKMPTIKREQECADSRMENILVLSSNIPDMSESMDSSNDMLYSDGLNVKNKSSSCRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDVVLENKLMVLGEENASLKTELLSLKLKFGLISSTSYAQEIQKVTSSTAVFFQEYSSSKPNMSYNSDHEHSVMTSSCISVIKHSPQSSLSDVSEASSMEHVQPSTIQSNCRSTDIKFQRVKREPVEVENFSRDAREDSNTFQGSIYANYIGSTFPGYSHSPPLVHINRSSSNSPRTSEADEGVVGKTSDGEDEQRVPKGPIHSPVELKNGHTTIIKVPEVNSSALPHKLRIKAKAMQIKVEALESELDSTQKLTLPIDMSSKRHLQLEKHNSENMVHSSLSPLSVQVTNIQDWPLKPGQWHHRELDKMPSLCKTSGIVHIKDNVYKAPESESLYLKQGIATLSAEVASLKRLIVTQEICASNSS
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MAMAGAVVVVPRCGTPISSALSGSETSCSSNSSSLPKQASCSRTPSSFHVSVTLSSASPSLLRSGSSYWNSWTGRSHLGNAQLLKVITGRQQLLSKQGIVGRVHASLLGVGAPEALVIAVVALLVFGPKGLAEVARTLGKSLKAFQPTIQELQQVSREFRSTLEQEIGLDELRNPKPLDPPSRPKSESPITGEMPQDLQQPSVQSSQIAQPPTIKKGPEAYTTEDYVRVTAEQAKSLVPEDLRKEAERAAWGGSPPPPPTDVVEDKEATGPAKPEEKKSEEISL
The following text describes a protein:
Function:
Medium subunit of the DNA topoisomerase that untwists superhelical DNA. Controls topological states of double-stranded DNA by transient breakage and subsequent rejoining of DNA strands.
Sequence:
MQLNNRDLKSIIDNEALAYAMYTVENRAIPNMIDGFKPVQRFVIARALDLARGNKDKFHKLASIAGGVADLGYHHGENSAQDAGALMANTWNNNFPLLDGQGNFGSRTVQKAAASRYIFARVSKNFYNVYKDTEYAPVHQDKEHIPPAFYLPIIPTVLLNGVSGIATGYATYILPHSVSSVKKAVLQALQGKKVTKPKVEFPEFRGEVVEIDGQYEIRGTYKFTSRTQMHITEIPYKYDRETYVSKILDPLENKGFITWDDACGEHGFGFKVKFRKEYSLSDNEEERHAKIMKDFGLIERRSQNITVINEKGKLQVYDNVVDLIKDFVEVRKTYVQKRIDNKIKETESAFRLAFAKAHFIKKVISGEIVVQGKTRKELTEELSKIDMYSSYVDKLVGMNIFHMTSDEAKKLAEEAKAKKEENEYWKTTDVVTEYTKDLEEIK
The following text describes a protein:
Function:
Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to a polar structure adjacent to the basal body.
Sequence:
MPKKKGKGKGKGKGKGKGKKDGKHDSKADRESEIEKLKSNASLWEAKFTVTDISRLEYREAARALAKANEELENQQYRAEKDTKDIIAFLKRTDFEKTATIAALEEELKRERAKSAQEKDLLVAEYMQKIDALEEMFRQRSGDFQRMQGELKTIKHYRKIKANLEEDLISIREKMYVDGRAHQESLARTEYKFYMARIRIEKEAEQKISQLAEQAHYEAVDQLGAASQTVITENIRLNEGLDYHVKEAEQLKRINVALTEKNSSLALFKETNELMKKEADSHVQSQHSEISELTAKLSTLEQALGIMSREFEQERVEMERSAGVNNTELEELEMLLAAREKELSKVKQLAQSIIEQRRELELFFHEALNHARKEIKAQQQHYRQEALKSYRWRMNEAHAGRLEFPRIRTFSNAPNSTNDVQTELEDSDKWNNLRSSNVDISDLTWEQKERLLNLLFAKLNGIKTRKAAHPPALSASSSEKIQVSSDAGSTVESPSMTFITQMTMANMTSDPFVLPALKST
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGIQGLLPFLKEASEPIHIRKYKGYTVGIDSYCWIHRGAVACATQLAKGEPADHYVRYCLKYVNMLRALDIKPVMVFDGRNLPAKAGVEDSRRERRETYSKKGRQFLREGKASEARDCFVKCINVTPEMALNVMKAVRSLGVDCIVAPYEADAQLAYLEKNGFVQAVITEDSDLIAFGCKKVIVKLDLAGNCMDVDSSRLNVAMKIGEKFTPEKFRYMCIVAGCDYLASLPGIGIGKARKLFQLTANPDITQVIKRMATTLKMKSTTVTPEYQEGFVQANNTFLYQLAFDPQKKKLQPLTPYSPEVTPATLTYAGKYVDEVKAYQMALGNINFDTMERIADFNPMVNKPYDKKTPRHLLSIWHKDFQPGPGLGCLNQDHIEREVTKGKEITVEVKQRLIQKKRQRDEEEEVGAPSDVQLSSMYTTTKGQLDGNQWMESQRVIPETPDKDVVEEEMKPSKRNRFATKLTSRNRANIVNSGEVVTSRFFQPKKLDVSSEKQQQIPNDKKLKIEEKENQRVSMNTSGLLEGIVDIEMEQEKQFKMEDDDDDIEDVIEIKLKETVSGSQSRQTHVTKSIDALQRFQRSSSASVLVKTERNLSSSSLSNSVKPRTALSSTHQSEDIPDSQKSVIEIESSQDSVCSTRSVDTCSQSSSLSSSQRQGTPRPRSAFSWSRKKELQGKDKDSKQPTQGTLSGFVFKPTHQSKPMPRQTAVGVQDGSLQGNSLSRRDSYEMPCSPVSQNSSSQLLRLSLTSSIPGSMDMLRLGEDVTFMDSQSSNLTESQNTSSITLTSDQTSQLIDNTDLEDVSPPIPPLPQLPLQIHLSNGEEEEEEKGEMMEGIRRTGLSRKRKKTFSSEEQSPGKIPSDVSSPDTDDVSLNSSTASSPSPAPALSSSSLQTTKHFGMATASQSNKDADSLRVGGRGATSCYFGGGEREMSQGVVRKKGMMQEEEEWENTPPGRGGVSPYKGRRNRNLSGKRHNQGPKAAFMNDENQQNSSNSEPKKQSAFLGQCKASGLSKKRRSSGKAKPDATPKGQTSLLAFMAKPKTKDPLISQKGVSPLSPNRANLCTDLTPETEGSLLSRQGRGFTTKRHIFE
The following text describes a protein:
Function:
Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MNHGGNSTMRHCSMKMTFNTDYDNLCIVFKSWHIGNLSQFLLSLLAIAILGYLFERLRSFTSLKETEFQRGYAGQQSEGLLTHHSKSLKSGRPFRLCALYAVQLVFSYFLMLVAMTYNAYVILAIAIGAAFGYRRSHCDTVQTVGLCH
The following text describes a protein:
Function:
May be involved in the modulation of rDNA transcription.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEKASLNIAQTKEIPLTDRRMGLRGWKACSRPHLLGRILLFMSILFITSAELSSDVSSREVYMPIFNNKLSFKVPPIKRSLLLGAALYEDFEYSSNNSASDGAFCTVFNAGMNDASREVVFEIHVMDVLQEETDSSRFGGTSHERGRQSLGFSVFNNKNGDLLRSKKNLASGTSVIEVNPGNCNEFLICFINLVYDGSWSSIDTEKSVTIKMTYNDKLDPDMLLHLVNQMTPQVVKALNTVSDGLFQIVSDTTLLQMESDRRDINEATYSYLIVGFVSLMVAQLISNIIVTTYLIIKIKSNPSSHIKKKGL
The following text describes a protein:
Function:
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton. Severs actin filaments (F-actin).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Note=Septum. Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.
Sequence:
MSFSGVKVSPECLEAFQELKLGKSLRYVVFKMNDTKTEIVVEKKSTDKDFDTFLGDLPEKDCRYAIYDFEFNLGEGVRNKIIFISWSPDVAPIKSKMVYSSSKDTLRRAFTGIGTDIQATDFSEVAYETVLEKVTRK
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MAASVTDRTPHLGVSQPISTLRPDQKDIVMTDQLIATLKKFNSYEPKEETEKRMEVLRSLNRLVKEWVKKVTAIKIPSGEGANAGGKLFTFGSYRLGVHSSGADIDTLAVVPRHIDRTDFFTSFKEMLRQDPNVTELHGVEEAFVPVMKLKYSGVELDILFARLALKEVPDTQDLFDDQLLRNLDQESVRSLNGCRVAELLLKLVPRQKEFCIALRAIKLWAKNHGIYSNSMGFFGGISWAILVARACQLYPNASASRIVHRMFFIFSTWTWPHPVLLSALDQDRNDIPTLCDLIWDPRKKNSDRFHLMPIITPAFPEQNSTHNVTRSTCHIIRNEICEGLEICKDITEGKATWEDLFKEVKFFSRYKHYIGMFFFLNCDHNLSAYLSSDHGYIHRRRGIELWRFLESRIRLLVQSLERNQDILIAHNDTNKHRPSPNAKFDVRPENTRITIWFIGLEFAEHATNLDLTSEIQRFRTNVELQASGVKGIGPNSQVEIDMFYMKRTRLFSIIGAAALKKGRDWKPPKNPPPPMGQVPYRTTVARTSSTNSVPTTPTTLVAPSTPLSEAMPSSEPDSTTNNGTPVSRKRLVQEATSTSETVTTSTLEDVPPEKRTRDDTLEEPILEMVVEVANGVVEESREVELDKDNGHLNGSNGLEASEKHMEVPQSV
The following text describes a protein:
Function:
Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation. Required for proper alignnment of chromosomes during metaphase.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Midbody.
Sequence:
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSMPSKGQPSLREAISMSCITNGSGINRKQNHTSSISIARKETLSSAAKRHKDVIINQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWVYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAVHPDKIRMATGQIAGVDKDGRPLQPHVRVWDSVSLSTLHVIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQRKSKVAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTIEPPPGKGPKGVYQISRQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNLEREIEVPDQYGTIRAVAEGKAEQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCMWNSVEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSVDGTLLAVGSHDNFIYLYAVSENGRKYSRYGKCTGHSSYITHLDWSPDNKHIMSNSGDYEILYWDIENGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHHRRVIAVADDFCKVHLFQYPCSKPKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLPLPQNEVIADTSSTKAPASATENARLCNAPQPPSQPLPGTAEEESRVSSSPTLVENSLEQSEWGSEDLGVVIDEEPASERGEKQGAAEASEEEQGAAPLC
The following text describes a protein:
Function:
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
Subcellular Localization:
Nucleus. Note=RORG promotes its nuclear localization.
Domain:
The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. The Prospero-type homeodomain is essential for repression of RORG transcriptional activator activity.
Sequence:
MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
The following text describes a protein:
Function:
Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MGGADVQAITIAVTTGRDCAMSGDYSAGCTYYENAVELITRYVRTLGDPHAIRQWSALLKEVQDEHSSVRQCDKEARGMRVYDSVARSNSYPEMNDPRGSAAYDDGYRQPIVVCHNSGQEDPMVWRPPTRGEGRSGAPARGAPPPRARSSQDDNKLPSWANNNNGGGGGPPARGNAAGPSGRAGSAPRRPTGNAPAGNAAAGGSYDRPWRQNMQGKQGAAGPGGKPGDKGSAGEKAKKQYSGPDQELAAMLERDIVDQGTSVKWDDIAGLEEAKRVLNEALVLPMIMPDFFTGIRRPVKGVLLFGPPGTGKTMLAKAAATETSCTFFNVSSATLASKYRGESERMVRILFEMARDLAPSMIFIDEVDSLCSQRGTANEHEASRRVKTELLTQVDGVHGSEKDKEPGPDGEPPAPKHVFVLAATNFPWDIDEALRRRLEKRVYIPLPGQAQRLQLLKINLRDVAVAPDVNLEAVAGQMDGYSGDDITNVCRDAAMNGMRRLVAGKTPAEIKALREAGMTGGQEPITSDDFREALRKINPSVSKEDIKRHEEWLSVFGST
The following text describes a protein:
Function:
Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Also plays a role in the primary envelopment of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.
Miscellaneous:
MISCELLANEOUS: Expressed in late in the infection.
Subcellular Localization:
Virion tegument. Host nucleus. Host cytoplasm. Note=Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus.
Domain:
The nuclear export signal is CRM1-dependent.
Sequence:
MDAARDGRPERRPRRSGTYRTHPFQRPSARRSLLDALRAADAEAAERPRVRRPRPDFQRPPDEDTSEDENVYDYIDGDSSDSADDYDSDYFTANRGPNHGAGDAMDTDAPPERAPEGGAPQDYLTAHLRAIEALPESAPHRSLLERTARTVYAHEFPPRDLSAGSRAPAQRARRSLRGFPRGGGGGQEPGPDDEGDDAADLREDLVPDEAYAHLERDERLSEGPPLLNMEAAAAAAGERSVVEELFTYAPAQPQVEVPLPRILEGRVRPSAFFAQMPLDALCRTPPNDQRVVRERRAWDMAGTPHGLLITTWSTVDPEFSIGGMYVGAPEGTRPRLVWRRAMKQAMALQYRLGVGGLCRAVDGARMPPTEALLFLAARAAARSAQLPFFVAAGARGRRRAAPARGGGWAAGSHAVHATGRVPHATLFRGSMGSLIYWHELRVMLTAVPALCARYAGAGLQSAELYLLALRHSEAPGYTANERYALSAYLTLFVALAERAVRWLYLAGAHLLGPHPTAAAFREVRAKIPYERLPLGSATLHDAEVETVDSATFQEALAFSALAHVYGEAYVAVRTATTLLMAEYAAHAERRDVREMTAAFLGVGLIAQRLMGSLEPAAELRSRRSGVRGPACPTVREGTLARYSLLADAALPLVRPVSLVEFWEARDGVMRELRLRPVASPPLAGKRRVMELYLSLDSIEALVGREPLGSRPVLGPLVDIAEALADHPHLVTGDGRGPRLGGR
The following text describes a protein:
Function:
Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MSPLTLAPSPTPRATMAELPVSETPGDPALCSGRFTISTLLGGDEPPQPAAYDSSHPSHLTHGSTFYMRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKEGSHLHALAFDSRPGHEMTDGLVEDEAGTGGEKSPAEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLIQEHGAPIVDPINDIRIIGVVTVTVLLGISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRGDIFVQNLVPDWRGVDGSFFGMFSIFFPSATGILAGANISGDLRDPAVAIPKGTLMAIFWTTVSYLAISATIGSCVVRDASGDLNDTMTPGSGACEGLACGYGWNFTHCSQQHSCRYGLINYYQSMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCVDQLYPLIGFFGKGYGKNNEPVRGYLLAYAIAVAFIIIGYELDKPHFSALELLDPLGLKGGDALRERAQRITELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSSSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLVGPRKQRMPELRLIANGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNISEMMQAHINPVFDPAEDRKEAIARGARPSVSGTLDPEALVREEQASTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKKRWSKCAIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHVLPDINQKPRAEHTKRFEDMIAPFRLNDGFKDEATVTEMRRDCPWKISDEEINKNRVKSLRQVRLNEILLDYSRDAALVVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSQAPVLSTEPEFETVAPLVRETPSNDYLNKYYCLPQLTEYLNSHEYKSIALQFPANDVADSALVVRLLKQTVDPSISLFILADTNYSPCCVDVVGANHIKADLVVHFGSACLNPVTMPVVYVFCNPEIDVKVMVDQLTEQIKDAEQPNILLDSDSKYYPEMPTMFKALREAFPDKIIVRSFIPNPQETLGLSEEETKPDAEEGYLYRRTHDDLDPQETMLIYVGTPSSSLALHYSTRFGATAYFNPVSGQAETPKTAIMKRYRYMNMARAAQTIGILINSLSMSETKEMSKKLQKAIAESGKKSYTFVVGKPNVAKLANFEVVDVWAVFGCGIGGIILENEEQYFKPVVSVYELGLALQPELSWTGEWEIDSNKVDLNVEVDEDEVDEPFFNPVTGKFIDHKPLHVQEYSDDEETQALVKSIGGSLTIKNTVTTAAIQLQQREWQGLGHDYGSGEEDGADLEEGRGGIARGYAVGDDERM
The following text describes a protein:
Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis during mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. In the complex, it may be required to direct the Aurora B/air-2 to centromeric DNA.
Subcellular Localization:
Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the central spindle from anaphase through cytokinesis.
Sequence:
MPPRKIKKDPAVVAMADTLETRVKDLLEEYKKKLREVALQTAKAESDRIIATIKPKYRDMPIMEFLASPPDDFYIESGEEEEEGEAAVAVKQELPSEPDMEIDDAAAAQKTSIPIGQNSGRNTVQVKQEPEIDDDAAHETSIPIAPSGQNSGRNTAADEHRRNEIITPAGQVLPLPTLQPEKPFRAPHVDEEIAFSVNGSPLVLAGRTTATAAGKENRKKSKKSGAASKKAAAAAGPLQPETENAGTSV
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MIFGIFALLSTLIWAETATSEVTRDYCSLPDPIYADGVSAADFGAAGWSYANAATWADFVVTCGGSFQSPIDIVTSGSTQESVQPQINYKSKDANTAYEEANKPYTKEYEGEYSEIEVTDASGSVIRYYAKQFHIHTPSEHTIDGKYYDLEIHFVHQAIQDDEQDCNKVKNKLTVFGIMFQESSSATDYDVFKPWFDSNATGEVESFDLNDFFSKMSDNTYYHYNGSLTTLPCSQTVNWVVFQQALPISSTQLKQFQDFLGDSTVFPIKHNNRPIQHLNGRKILKGTAIAASVTEIPDVEASFAQTLAMAILMTVFLIQ
The following text describes a protein:
Function:
May be involved in protection from oxidative damage.
Subcellular Localization:
Mitochondrion.
Sequence:
MDSSDRPSLRQRLSNWGRTDTKPAATDLTAPPNDPSENMELPPLPPVELLGYSHSTRTKIMTTELADEIRNLVPERIKLYRSWQLQYSLEQHGTSLTTLYHRNIPPHGDTARNGFVLAVKNSRGQVFGAYTDQHYHVGGKKFYGNGDCFLWKVKNADSFQAFPYTGENNFVVYCNPHFLSLGGGDGKYGLWLDDALKTGVTYPCATFGNEPLGDEKFDVVAVEVWRVGE
The following text describes a protein:
Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLGERNGSSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNRKKLEGGGERRGAPAAATAPAPTAHKAKKAAPGAAGSRRADKKPARGQKPEQRSHKKGAGAKKDKGGKAKKTAAAGGKKVKKAAKPSVPKVPKGRK
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MARLKKSNAGTCASNLPITRSQTVVCRAAIVGAKAKTPAQAPPKSSSFRDSTGKKRYRPGSKALKEIRHYQRGTGLLIPRSPFTRVIKQISQELTGNSAPLIRLRFTSEALECLQVASEAMVIQLFEDSVWTMVNAKRLTLMVQDIQLVRRIRGNL
The following text describes a protein:
Function:
Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MSMNNSPNVFSDPNLNRFQVNVINENNDNTTHAQGDPDSQHHEETSFAADSNNRLQISYRPGNREGYDNFPNGDSTKTGGSFHPYDTHNNTYYLKTFGHNTMDVVPKIDYYRNSGSVSGVKMNRPSLMEIHEQLSKNITVTSGSVDKFAKVDGIGGDAELNKEEELKGGFVKFGWVKGVLVRCMLNIWGVMLFIRLSWIIGQAGIGLGVIVILLAVLVTCITGLSTSAIATNGFVRGGKKTLGYFLRIWVKCFLSGIFSGLGVIVICLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVELLKSSNAIMVDATNDIRIIGAITVVILLGISVAGMEWEAKAQVVLLIILLVAIVNFFIGTVIPSNNEKKARGFFNYQASIFAENFGPEFRGDEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAILLTTIAYLAVAICAAACVVRDATGNVNDTVVFGMNCNGSSACALGYDFSSCKTQTCDYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYRALHFFAKGYGKNNEPIRGYVLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAFRYYNMWISLFGAVLCCAVMFVINWWAALITYAIELFLYIYVTYKKPEVNWGSSSQALYYVNAIDSALDLTTVDEHVKNFRPQCLVLTGAPMIRPALLDIAHSFTKNNGLCMCCEVYTGPRKLCVTEMNSGMATKQAWLTKNKRKAFYAAVAADSFRDGVKSLLQASGLGRIRPNTLVFGFKKNWRHSTAAQVENYMGIIHDAFDFEFGVIIVRISQGFDLSQVLQVQEELKRLEQERQALEATIKDSEFEEGNWGIRGFFRRATKLHITKTMPPKESSINTISSMHMGEFNQRLLEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIFTGGKVTRLEEEKLKMASLLSKFRIKFADINIIGDINMKPSKESWKFFEEMIEPYRLHESCKDLTTAEKLKREAPWKITDAELEAFKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGIVSDYLYMAWLEILSKNLPPVLLVRGNHKNVLTFYS