lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Miscellaneous:
MISCELLANEOUS: Present with 178 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MTSKPSTRNDYLPRETHNGEYTGDSPEWQLQINITNKIGGINGDIWLSRDGRSVKWCIEDQCLRQFTYNQKIIKAGYIDFEKTPDCFVVVLSDIAHVYMLKNGGSTTVCFPFQIGNAFWYANGVILERETSASFMDGGYDLKPIEFDLKHKYITLTDPMAPFGLISITNTFKGGINSASGNKTDILQDFQLVLFPSDKDKCIAVFLDRNSKVLRFYYSRILSSDQSRKGELTISSTKKTGLDAAGNSQKSGGISKDLRKFSHLTRRSTSINSNSHDFNAAERVLSGNVGNASGRTDIFALPSSCSRRSLSATLDRMGNNIAPTNRAAPSGFFDSSSANTATHSNITPVSQPMQQQQQEYLNQTATSSKDIVLTEISSLKLPDDIIFTSRRLSSILSKLKFLSLRFERREGLLIFHEPTHFCKIWLIDLLPDVLDSIPFKIYGNSPQNMIRLENLKLKEPSRIQAMYIHELLESCLILVSEGQNKEEYKACLYDPFVKITSPSKNISEELTKQNSLPSLQKLFPYPETSFTKLCFEAVKYITSPAFNISFIFLWQSAYSILLSRANDDVVGGLKMEHDAFSLVLSLLILPIPSSSAQEYQEYKEIYERDLFQHLKQDSEITSSVLPRIVIGLHLIREEYSLNVLCRNEHALLGQFLRFATAAMGWPDLWQSYYVPKMDSESKTFLHPREQNSTFFHPLDEPPSITKSLYSITENSSIPLCPFISFSRLVATDTQVELRITPRSFKILGLYELVHSPNFLPDYVLGILSSFKVDKDELQTYPLGILVPLQNILKILEDKLSEVRDNLELLDRADLQRCSAIINSIRSDSKEVLKRGQRDSYMLCKVPLAKNRSSLSKKPSDIYSILSEIVKSASQVPLDGSAMRMSNIQDDEDIDEGRSLKLNAGLIFSEDKRFTHVVSLLAYYRPTKTQFFTTKTEYAQILAQKKYFAKIMALRTCTNGVGWGAVAYATEKPISTQKWVIQPLNLISVFPDDTKITVKAPEDIAHDIVEWGQFHAGVSSGLRISKKATGITGSWIAFNKPKELDAYHGGFLLGLGLNGHLKNLEEWHIYNYLSPRNTHISIGLLLGMSSSMKGSMDSKLIKVISVHLVAFLPSGSSDLNIDLKLQTAGIIGMGMLYLNSRHKRMSDSIFAQLVSLLNVNDEMVADEEYRLAAGISLGLINLGAGQTKLRKWDSSLLGLGDDLPEDVYDSSDVEQNVMYEDLTTKLLEIVTSTYDVENDWIPENSQIGAVIAIMFLFLKSNNFGISNMLKVDLKEILKANINTRPELLMYREWASNMILWEFIGDDLSFIMKDVDIGVKFSELNTDLLPIYYTMAGRILAMGIRFASTGNLKIRNILLSLVDKFLPLYQYPGKQNLDFRLTISVINVLTNVIVVSLSMVMCASGDLEVLRRVKYLHEVASGPYSDLFQEIPSSKSDVSGVTQVTSNTNTPGNSDRERVDETAASLDDERSSNGSDISDPTAYLEDKKDIDDHYGKFISTNLALGFLFLGSGQYALNTSTLESIAFLSMSVLPTYTTPHPLQELKHFWSMAVEPRCLVIKDISTGDAVNNVPIELVVEEDVEKEEVIREISTPCLLPDFSKIKSIRVKMHGYFPLEVNFTKDYSASDFFSGGTIIYIQRKSESVFENKASFRNVEDIHVALKRKAAESKNYSRLNLKNEQGNTTSSQLVESLGIQDLTMVELDTLLSAGNNTALTDSESYNLGLLCSDKNSGDILDCQLELWYKSFGPHDE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MASQGGGLPMASQGGGPPMASQSGGPTMASQGGGPNYGFPRRRSRLPKKVVQAEKGPSDNINTVHCTSPKPRLRDIVPPGDTSTPHLIIVIFTWKLSEQPERADNRAVGGHMMCNRVELQESLGGAQYSLANVLSVFKGKSNAKKYICSDCGKSCPCHSAYIRHQRIHTGEKPYSCTECGKSFIQSSDYNNHVRSHTGEKPYSCAECGKSFSRSTYLLTHSRTHTKEKPYKCNVCSKSFGQHSHLALHLRIHSGEKPYICIECGNSFSRSSTLVKHKKSHRRKTLHVCVKRNEGEASGTWGAESGKRDIPEFPSLSGQLVVVKSENQMQSEKRNPQKLYKGAKKGFPRPIRITLDKCPVVEMRSEGQLRMLPRRHKFLRKKKLQGPPSESDICLWSSHIGGSSPSLDCGNCEVPCTGTGVPCMRGSQMRTQRLINQEYKQLVPHREKPYTCAECGKGFSRSTYLVTHSRTHTKEKPYSCTECGKSFVQHSHLTIHLRIHSGEKPYPCLECGKHFSRSSTLAKHQKSTGKGTMRHFVRHGGRPYCAQS
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MRKARGKAAKGGRAVTGDPIGDAAVLSALFANSPQGLFVFDSEQKVTRYNPAGRGVRGLPEEDVVGQGIADFVPGFEAVELQGLIDEVLATGEALRGRLVRGRAPSGPHRTLAVEVSLFPLRDLGDGKPGLVGVVEDVTERQAAADRLAVLSEVHATVGSTLDVRTTGDELVAALVPAFADAATVDLLDDGVVAAERAAGPPPTEVPLRRVAFAPPAAEVSRKEGDSRPLPFPTPYTQVLNDMRARLVRVSSDDPWLSADPEALEPLVRTGVHSMIVAPLLARDTVLGLLTLYRHRTDPFEEADLDVARQAAFTASVHLDNAHSYRREHTVAAALQRRLQPGAIPLLSAVETAHVYLPESAGGDWFDVVPLSGTRVALVVGDVTGHGIEAAATMGQLRLAVRTLALRDLETDELLTHLDEVASQLADASGPGGNTPVATCAVTVYNPVSRHCTMVRAGHPAPVVIDPDGVPRAVDVPQGPPLGTGGGHVFTPAVLELAPGTLLALHTNGLTRGNGDEGEAARRRLEHILASTTRPLQELCDTAVYHMAPSRHDDAVLLLARTRALPPEHVADWTLPADASVVGTARRLVDRQLASWGLDEAAYTTGLVVSELVTNAIRYGKGPVRLRLIRDRGRLLTEVTDANSASPHLRRARENDEGGRGLFIVMRLSTHWGVRHSRHDKTIWSEQRLDAGPPDTSGLLDAFDVTDAAGL
The following text describes a protein:
Function:
Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development. SPG7 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (By similarity). The m-AAA protease exerts a dual role in the mitochondrial inner membrane: it mediates the processing of specific regulatory proteins and ensures protein quality control by degrading misfolded polypeptides (By similarity). Mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (By similarity). Acts as a regulator of calcium in neurons by mediating degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU. Also regulates mitochondrial calcium by catalyzing degradation of MCU. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRHTEKVLQDNLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQRWIDAQREKQDLGEEETEETQQPPLGGEEPTWPK
The following text describes a protein:
Function:
Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR (By similarity).
Subcellular Localization:
Nucleus. Note=Found in all nuclei in the germline, including oocytes, but not those of mature sperm and spermatocytes.
Sequence:
MVTSDETVLATTTNKTSITTEPMEPKSSDESTDSETDKIKILKAEQREALTEATGSVEVNGNEENGHVECATVDEVAHVEEDKVEEATNSVVDLSSNGSSATTSVPVEEQEEKANEDETNDVVMETSENGENGKEENGTAMEVAENPAVTENGSKSDGETETDRVAIKDSQEDDSEPVNGSVKPEEKEEKNDTDAPMEEEDQNGKGVKRPVECIQLDDDDDDIQEVSPPVPAKKQKTEETKQEPKQEAKAEPADDNEQAQIRLLDKLQEYVGDQRGQPCNKTRKVLDTLLGAINAQVQKEPLSVRKLILDKVLVLPNTISFPPSQVCDLLIEHDPEMPLAKVINRMFGEERPKLSDSEKRERQQMKQHNPVSHMTKLLVDIGQDLVQETTYCDIVHAKNLPEIPKNIETYKQVAAQLKPVWETLKRKNEPYKLKMSRCGVCGFQTESKLAMAAHKETLHFTGSKFQCTLCKETDTNEQRMKEHYFEAHLIIAKSEEKESKYPCAICEEDFNFKGVREQHYKQCKKDYIRIRNIMMPKQEDHLYLNRWLWERPPVDPSIIQQQQAAALQQAEQKKRHQQALLREQHAQAQAAQLLRKQQLQQQQQAQRLREQQAQAQYRQMAQLIQQQQQQQNRNNANNMSNSLIQAMQAQLRRSGTGTSPQNLNLLQKQMAAVLKNQNPAQIQALVASMNKQTQSPKTPTTPKVAKAAATPTLPLAMSASSSSPGVSFQCEICDQTVHEKDKYLSHLQVLHKQMVGKTLQDMTQGAPLACSRCRDRFWTYEGLERHLVMSHGLVTADLLLKAQKKEDGGRCKTCGKQYAFNMLQHLVADHQVKLCSAEIMYSCDVCAFKCSSYQTLEAHLSSTHPKSADKKKEELITLDD
The following text describes a protein:
Function:
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.
Subcellular Localization:
Nucleus.
Sequence:
MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFALDPAAVKKPSFCIADILHAGVGEPGPAAEGLVGASAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAFHQHLPQQSPTQQQQPQQQPPPPPRAVSLQPPTSGTRVVPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLAGLQPSAGQFFASLDPISEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGVPAEGEREERSPSRSEGEAESESSDSESLDMAPSDTERTEGTERSLHQTTVIKASAAGALITASSSTSGSSFSFSSTSSLGSGNTHVGSASSLGGNCSELPSAHQPSVTSSPQSPEIAQAPLAGL
The following text describes a protein:
Function:
Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MPPVSRSSYSEDIVGSRRRRRSSSGSPPSPQSRCSSWDGCSRSHSRGREGLRPPWSELDVGALYPFSRSGSRGRLPRFRNYAFASSWSTSYSGYRYHRHCYAEERQSAEDYEKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEEEVTHQKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKRVKAKKKKKKKKHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQPNVADTMDLIGPEAPIIHTSQDEKPLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRESKILASFREMVHKKTKEKDDK
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MGELNATGYRFSFAWSRIIPITCINEMILYNMHRQDFKDYADLCFKEFGGKVKHWITINQLYTVPTRGYAVGTDAPGRCSPMVDTKHRCYGGNSSTEPYIVAHNQLLAHATVVDLYRTKYKFQKGKIGPVMITRWFLPFDESDPASIEAAERMNQFFHGCYYYPKGIYYVMDYFKTKYGDPLIYVTENGFSTPSEENREQAIADYKRIDYLCSHLCFLRKVIKEKGVNVRGYFAWALGDNYEFCKGFTVRFGLSYVNWEDLDDRNLKESGKWYQRFINGTVKNAVKQDFLRSSLSSQSQKKRFADA
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Sequence:
MEVLYRKYRPKTFSEVVNQDHVKKAIIGAIQKNSVAHGYIFAGPRGTGKTTLARILAKSLNCENRKGVEPCNSCRACREIDEGTFMDVIELDAASNRGIDEIRRIRDAVGYRPMEGKYKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTIISRCQVFEFRNIPDELIEKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLEQVWKFSEGKIDLETVHRALGLIPIQVVRDYVNAIFSGDVKRVFTVLDDVYYSGKDYEVLIQEAVEDLVEDLERERGVYQVSANDIVQVSRQLLNLLREIKFAEEKRLVCKVGSAYIATRFSTTNVQENDVREKNDNSNVQQKEEKKETVKAKEEKQEDSEFEKRFKELMEELKEKGDLSIFVALSLSEVQFDGEKVIISFDSSKAMHYELMKKKLPELENIFSRKLGKKVEVELRLMGKEETIEKVSQKILRLFEQEG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADNESDLETYGLELALDTLCLRYCSKESTLSSKDYCSKFCELVEEYTGQWQVPLPQLKVLRTAICCFTRATAGFPDDCQHIQYVLSSLALSFFELMLFFSKEEFVEEPLKDILDSFQECHFQLLRHRNIYLQHVKQVIKGGGPWENPVLQGILKEADLPQNEVEDFLSSEPPIFLELRVRYLQACERIQEAMTLAKSCLENHEAAQHLYFHQAYLTCLYKASLYENLHKEMAEIDGRDAVEIICNTESVEKDELLLSLCKAFLTRQLHNGDMYYIWDLVFIWSRLYLRAHPSRQGFLSECLQLASSATNVRAIFPFIKLVTAELGNKGVEVCVELCARALQLCDKQADTVTQPLVCKTIAFLLPHDLEICRACALLVFCQERSLEAYRTVCLLYMHPDQEPHPDSNTVRTNVRFHILQMLKERLCFDPEFWNLLTLRTRCLELMSDKVTKDAVLSEMKEEEEKECTPEYLPNKSVHSSCILGLKSCHCSPAATPNETQKQTLTNGVEEKSEPNDAHLRRMKWRRRLPKRTKIISNEEFDPDPEVTYDLESTSLGSKPAYSLRQNHTKMEQSASLKLPLNRKREYLSRCVKSQILKRKGQKRRWLQGLPRLEQAQTVKENKIKVRGRKRGRKPLHKLELSYPDNEMNLEKYSGGEDEKTGTPEKDRDWPYRDIELENQNEEKENEPEHQRDPGNENRGNTSLVHASSYCQQIQGESPAQFVPELYGVPLVEANPELDGPLLKLPEFPIELLHNYSLQSQQLENESEEHLECKQSDEMSAEEDLQPEQNLEIPKLELKAKATWRERVLRTQKYGHLSYRCGLCCKTYKGLNVMRHAISHLKNRKLKCILCGKRFKQFPLAKKHVLDHIDEMCKQKPPDEEPSTDTTPTANGIIDDTKEGKTPSAKVEASEQKSKSKTKLESLTREERIIRNVRILLKKTSGIQKKDSTSRQVDFKDEQVVLSDDLVVIKEPFLRKDKEGGEEQERPAGENGCNVDVKFHLCPSDSCDKVFMRLGSTITKHALRCHVEEEKVLEKAFLWSKRKCSFCLRQIQFYQHYKDHVKLHGASLPYFCYHLECTKRFAQQQELKDHVRTHQPFTPQCQFTDCEKLFSNCQGLFDHEWRHYVPVPQKEELEQITPEVKQPSSEAPWKQRVKVEELWLQSRKGEAPTLDVHVDRVKAADESSTGSVPDKSPNMSYSEHCSKEWDDDQHVESGKPTINGYEDVGRNAQEPPSNSNTPAAIKSSAKKCQKKVPKDWDVIDVKDVEDVSTLAEGIQKNMGEPHITEHKTFKPEDPAYAPFVKAPFIRPPPSTYLDESVLSMPKRRSSDQPPPKKYYKKNKQTAQQKDTNEVVSAPKQIRHRCDKCLSSFNTLEELQSHQTLNTCSSLFGFDSDDEN
The following text describes a protein:
Function:
Auxiliary transcriptional regulator of sulfur amino acid metabolism. Involved in the transcriptional activation of MET28.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDQDAAFIKQATEAIVDVSLNIDNIDPIIKELLERVRNRQNRLQNKKPALIPAENGVDINSQGGNIKVKKENALPKPPKSSKSKPQDRRNSTGEKRFKCAKCSLEFSRSSDLRRHEKTHFAILPNICPQCGKGFARKDALKRHYDTLTCRRNRTKLLTAGGEGINELLKKVKQSNIVHRQDNNHNGSSNG
The following text describes a protein:
Function:
Zinc transporter that may be involved in zinc uptake from the rhizosphere.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MERFVQFLRRGNGLMAASLAAGSCAEEVAKAEGAGCRDDAAALRLKGVAMATILVAGVVGVGLPLAGRKRRALRTDSAAFVAAKAFAAGVILATGFVHMLHDAEHALSSPCLPAHPWRSFPFPGFVAMSAALATLVLDFLATRFYEGKHRAETERVKAAAAAALAASSASDDDITVVTVTEDDNDNKAPLLQPHSHSHSHPHGHGHGHELAQPEGSGGEGEVPAQVRSVVVSQILEMGIVSHSVIIGLSLGVSRSPCTIRPLVAALSFHQFFEGFALGGCIAQAQFKTLSAAIMACFFAITTPAGIAAGAGVASFYNANSPRALVVEGILDSVSAGILIYMSLVDLIAADFLGGKMTGSTRQQVMAYIALFLGALSMSSLAIWA
The following text describes a protein:
Function:
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Colocalizes with UBC9/UBE2I in nuclear spots.
Domain:
The RWD domain is required for the sumoylation enhancement activity.
Sequence:
MAEPVRQELSALAAIFCGPDEWEVLSLSETDGAVFRILTKAEGFMDTDIPLQLVFHLPLSYPYCLPGIVVNSKHLTRAQCEIVKEKLLEQAETLLLEPMVHELVLWIQENLRHILKCPEAGGGSEKCSSAASMTVDDGLWMTLLHLDHMRAKAKYVKTVEKWASDLRLTGRLMFMGKIILILLQGDRNDIKEYLILQKTCKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSSLDELQKEFETTGLKKLFSECVLRLVK
The following text describes a protein:
Function:
Zinc transporter involved in zinc uptake in roots. Targeted by BZIP23 transcription factor in response to zinc-deficient conditions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSRFRKTLVSAFVLCLVIFPLLVSAAEEENQCGGSKGGSAAEKASALKYKIIAFFSILIAGVFGVCLPIFGLKTESNFFMYVKAFAAGVILATGFVHILPDATESLTSSCLGEEPPWGDFPMTGLVAMAASILTMLIESFASGYLNRSRLAKEGKTLPVSTGGEEEHAHTGSAHTHASQGHSHGSLLIPQDDDHIDMRKKIVTQILELGIVVHSVIIGISLGASPSVSTIKPLIAAITFHQLFEGFGLGGCISEAKFRVKKIWVMLMFFALTAPIGIGIGIGVAEIYNENSPMALKVSGFLNATASGILIYMALVDLVAPLFMNQKTQSSMKIQVACSVSLVVGAGLMSLLAIWA
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTQILLLKRLHNQHDYNDYNHILFTEENNLKPVRNRAQTDDIDSEPDNYVDALNTIESESENDIDYITKREVQQLSSRVTCGMIENGVSEAPPNLMDNNLSDVVFQTDYTVLLNEEQGHLADSLQENHVLDLLSKPNASNLGYVSPSDDLDRENMTRDTASLNKEPFRDLPDSLQDIPPLTSEPHVSNLGPVSPSDVLYSEEMTRDTICFNKEMFGNLPDSLQEISPLTSEPHASNLGLGNPSDVPYGEEMTRDTVFFNKETFGNLPNLQEIPPPTVEPHTSNLGPVNPSNSPHSEEMTTDTVSLNKEMLANLPNSLQETPALTLEPLASNLAFVSPSDISVSKEIAKNIADSHPSKTPACEQVPRPSENSVLDNSVCTDSYIGSSTVNDTVSAPIETDISFSGSKNSNLPDEEAGKINNNICKSEETHRESLADHSVRFWTNGGLLGLEPSKPPDFNKSTSLGQGSLSTKSETDGGSHHNSMQKSNGYKEEWESSEEVAEQILKEPNSRFLTSGHNDDQACVSEKATGNSQQSNGFGQTERDNLGEIRVIAPGSILPSTPDTKDSTEPNQGNGENSSRVFGLSRRLLINSFQRKVSFDEKSEHYNSLKSVILDQSGQNGIVGPSLPETTSSKEKVGSGYPIKSLPPSPPLEHMKISFHPVSGLETSKLKLRFPDGSNHHESVNDMFPSFQLVPEASLPLDGSVSHSDDDDTFCRSSPYISDDGQSPRSDYNSDQWESDETPESSDQGVHDSPCRRSSTESVSNDDTNAKSGHGTCTMNGVEHSLSRPLLDFPSYDNVNPALEKESKKHSKCNNAVMSHSHAEPAQPPPPPPLPPTQWRVSKPQLDMTSGTQYCMSEDAEHIGDHSLPDSTILQQPRVTQVEQIQINHDDHESYDNIIYKLKDKLDQQKLKGQKEANQLRMGKEIDEREDFLYQIRTKAFNLRPTVSGKSNDTTGSTANVKVTAILEKANAIRQVVASDDGEDDDNWSDT
The following text describes a protein:
Function:
Riboflavin-binding protein which might have a role in retinal flavin transport.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Cell membrane; Peripheral membrane protein.
Sequence:
MDCRVHMRPIGLTWVLQLTLAWILLEACGGSRPLQARSQQHHGLAADLGKGKLHLAGPCCPSEMDTTETSGPGNHPERCGVPSPECESFLEHLQRALRSRFRLRLLGVRQAQPLCEELCQAWFANCEDDITCGPTWLPLSEKRGCEPSCLTYGQTFADGTDLCRSALGHALPVAAPGARHCFNISISAVPRPRPGRRGREAPSRRSRSPRTSILDAAGSGSGSGSGSGP
The following text describes a protein:
Function:
Negative regulatory component of the MBF complex involved in cell-cycle-dependent transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDRSMEPLTPSRLNTLGERPTNEVYEYGKGKNVQHLFPITPMQRPLGKENAAPGTISPIAVRSRNVRAVEIADENACEEPVLKIKSVSSTESEEEKESSTEIGEKQEKETHLEPKTPVQTNTNNNHLDDIQCCAKNLRLRLELAMYKVQVNQTFSPLQDLPIVAKTKLHNCPNSEPVTSIWNQRSLSSGKPPSLHLSGNRRLSMGSPTKSIYDQNGLTTPRPIGSDDLTHMYDPYTSPLRTPSRTLSRSSSHYLWVRHGKLTRSVSLLQHKTPRRIRPKSLSKSNSTPLKHLSAQKPNSNYYTGPPTPVSISNTPENIHPSSSEVRRIASHSKQFSDYGLIR
The following text describes a protein:
Function:
Transcriptional regulator that plays a role in retinal development and maintenance.
Subcellular Localization:
Nucleus.
Sequence:
MPRRKQSNPQPVKLESEDGVVVCEPSCLVLDSDILLSGELEFTETDLIGLDREAGVTVFSLSVEDDPTAPTDSTFPAILSCKGCGQLLEDTPLAAGLELGVGLALGAELYCLTCEAAVQHSASIDSFKVDSPDQLNLPPNSTPDKKRRGVAKSEGDIPQKLFSCSLCTFTSRYSNHLKRHMRIHDGQKPYRCPACPYASAQLVNLQRHTRTHTGEKPYRCVQCSYACSSLGNLRRHQQMHLQERPKKKEKRQGKRRKSKGGAEEVMSDLTLRVSQDSMYLQTLASFSTASGPLPVLLFPLCCRVCGLTLEEADLEGDKAEGEAESDGAQVCRRCSLDLLPKEGSQSRHSTRRASRRSTKLYRCPNCPFLSHYPNHLARHSLTHSEEKPHHCPCCSYSSSHLDNLKRHMRVHTGEKPYQCPSCSYACGNLANLRRHERIHSGAKPFHCSICGYSCNQSMNLKRHMLRHTGEKPYACGECGYTTGHWDNYKRHQRKHGHNTDSWDKHAPINGLSWDKRAPDSQSQGLEHT
The following text describes a protein:
Function:
Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation. The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins. The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin. The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis. The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins. During replication, the complex helps to prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2. The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination. It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57. Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to few distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots).
Sequence:
MARRPDNQNPEGENLRIKRVRLESVRQNDEEEENEVSRTQNIVTDNRHDSPEAVVEIIGERALENTSEEDGDDDLSLFRALEEDPGSDHNTSNNDSGNHDRETMHTEEPEASSGNNITLTNNVEELHTMDVLSQTANTPSASPMLDAAPPTTKPGTNSKEQTVDLTADAIDLDAEEQQVLQISDDDFQEETKEAPKEYGAAKDYRCPICFEPPETALMTLCGHVFCCPCLFQMVNSSRTCRQFGHCALCRSKVYLKDVRLIILRKKQVKKKVKS
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MEKDQKVASEDPKIDLFEDDDEFEEFNINEEWDEKEEGKDSAQQWEDDWDDDDVNDDFSLQLKKELENNAEKS
The following text describes a protein:
Function:
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Sequence:
MSVSPDHHAQDAHLQIDQQWMTHALRLAERAERDYDEIPVGAVLVDPTGALLGEGWNFNIASHDPSAHAEIMAMREGGRRLANHRLIGCTLYVTLEPCAMCAMAMIHARIARVVFAASDPKTGACGSVFDLLADPRHNHRVQVSGGVLAAEAGLRLTNYFRAKRGKPPLVP