lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels.
Subcellular Localization:
Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAEAHQAVGFRTSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPLSWLFLFSAIQLAWFLQLDPSLGLMEKIKELLPDWGGQHHGLRGVLAAALFASCLWGTLIFTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVRKYLESVRPVLSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYGFTLVAQAGVQWYDLGSLQPMPPGFKRFSCLRLPSSWDYRRVPPRLADFCIFIEMGFHHVGQAGLELLTSGIHPLQPPKVLGLQVSDWWEEFVYLRSRNPLMVNSNYYMMAARAGNAVHALLLYRHRLNRQEIPPTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRVGTHSRNSLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRGTWAQVRRSLKTQAAEALEAVEGAAFFVSLDAEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPTLPRPQRLQWDLPDQIHSSISLALRGAKILSENVDCHVFPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYVVSRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDDMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKEDSRHRCGFLSRQTGASKTSMTSTYF
The following text describes a protein:
Function:
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Subcellular Localization:
Endoplasmic reticulum. Lipid droplet. Note=Lipid droplet surface-associated.
Sequence:
MSMNKGPTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYNSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKGTISTRLRSARNSISVPIASTSDKVLGATLAGCELALGMAKETAEYAANTRVGRLASGGADLALGSIEKVVEFLLPPDKESAPSSGRQRTQKAPKAKPSLVRRVSTLANTLSRHTMQTTAWALKQGHSLAMWIPGVAPLSSLAQWGASAAMQVVSRRQSEVRVPWLHNLAASQDESHDDQTDTEGEETDDEEEEEESEAEENVLREVTALPNPRGLLGGVVHTVQNTLRNTISAVTWAPAAVLGTVGRILHLTPAQAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPSAEAERKGSGARPASPESTPRPGQPRGSLRSVRGLSAPSCPGLDDKTEASARPGFLAMPREKPARRVSDSFFRPSVMEPILGRAQYSQLRKKS
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAKRGYKLQEFVAHSGNVNCLRFGKKTRRQFLTGGDDQTVNLWSIGKPTSTASLSGHTSPVESVAFDSAEVLVLAGSSSGVIKLWDLEETKMVRTLNGHRSYCTACEFHPFGEFFASGSMDTNLKLWDIRKKGCIHTYKGHTRGISTIRFSPDGRWVVSGGFDNVVKVWDLTAGKLLHDFKSHEGHVRSIDFHPLEFLLATGSADRTVNFWDLETFELIGSTRREAAGVRSMTFHPDGRTLFCGLDDSLKVYSWEPVICHDSVEMGWSTLSDLCIHDGKLVGGAYYQNYVGVWVADISLIEPYGAGLTPERQSNLEQKQEHVECRLERVGSNRSSNSSLRCTSPDIDSKEIKNIYVDSENPVTIKKVTSHSPKVVPPSDYKENKKQSSQKLNSAIDLPAKTNGLAVSKSFIVPSVVPRDIPEAKNLDTCRRESITANRASGGISQKPSHIKRLSNNKFDMEKISVTLESESTDKLPCTVDCKNESDIDSRRMTDNSSRECFEAKDSAVRHGGEEPEKVSLLPLLNNQENRNVALEGRKELNPVKFVNGVAVVRGRTRSLVERFEKREGLNMDDILKIDVVSQSKTEEVEISPLAPSCCKDEEPETFIKKRNEEPETTPSTASRFKAEEATRPLPPSHSGIEEANACTLPASQYEVEELEASNKPDSKFKSEEVKTTHLPASHVEKLEASPMPASQFESEEVRASHLPVSYSKAEQFEASPKPASQVKSEDVRKSRLPASRSKAEELEASPVPSSQIKPENVRRSRLPASRPKAEELEASPMPVSKFRTGARTSRLSAFRSKTEEAKTSRLLASRSKAEEAQAFRLLSSGSNAEEPLTAPLLNTDQQTIARRESAQNDNIVIEDLMQSHDVLLSSFRSRLTKLQVVRHFWERNDIRGAINALRKLPDHSVQADVVSVLVDKMEIITLDLFSCLLPVLLTLLDSKVERHANVSLELLLKLVAVFGPVVRSAVAAPPSVGVDLHAEERIQCCKQCFAYLQDIQKVLPALTRRSGLLAKGALQLNLLLQES
The following text describes a protein:
Function:
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSFFLGQILEKMGSIDKDIRFMATHDLANELEKDTFKMDPTYENKIVTKLLALTADSANNVQENVVKCLGLLIKRVKDSQATEIIDTLSKNILEESNKEELVEISGIGLKTIITNLPSEGSSISTLVIKNLVPKLLIGIDSEKLKDKNEIKMSCLDILNDLLQKYGSFMIGDLENIQKVVLPKLNATRPAIRKRAILCLANIAFPSPDNLFNSLLDYIIKSIEEAKKPDHISTLIQAIGAICKSSGYRLGKYLPKVMPHVLNYCDNNKFEQNDELRENCLLCFEAIIEKCQKDVTPYIGEIITLCTKYIKFDPNYSDDGEGEEDGDEEEEEMETSGDNDEEQEEEEEEEDLSDDDDISWKIRRSSCKTLCAIISTRPELLVELYQKVAPVLYNRFKEREENVRLDIFTTFVLLLKQLNKKLANPQAKEVLKQQVPKLVQSISKSLIDKSIRTRVGAIALLKELVMIIPGSLTGQVSQIVNGINLSLSEKNTNSNLKIEALVLLKLLLINEPAQSFQSHITSLSTHIVKCINDSYYRIASEALRVCQEFVIVFNKIRSSTDCKPIISNLFAANFVQLKAQDIDQEVKEAAISSIGTIITLFGNEIQSELQPCLSILLERLDNELTRVVTVKVLSRIINSSINIDLSSILPSAIKLLSTFLRKNNRVLKQSSLIALNDIVKVCPNLLPSSLLTGILTEMATLINESDLQITHLAFVFIQNLLKNYSEKHQAATLVNEKCIPPTLALLKSSLLQGVALESLLSLFATIVQLDEPGMKYEQLLTLLFNTAADIKQPVTRQSFHSISQCIAVITVNTTPALRKQTIHNLICNLSSVNEPLVLLSLSCLGEIGRRIDIHENENLQESVYKTFEANNEEIKQVAALCLGDIAVCSLQSYLPFILEQIKNQPKKQYLLLHTLRETIVKLSHTDEGIKTIHPFLQSILPLLFDNCVNEEEGTRNIVAECLGKLSMIEPNEIIPKLVEKIKSPSPLERSTIVTSIKFSIMENKEVVDQYLAPNISQFLSLLHDGDLIVRRSALLSLNYIAHNKPNLIRNDLSVYLPILYNNAKIKPELIREVDLGPFKHKVDDGIEIRKTAFECMYTLLDTSIDKIDVAPFIVSLCDGLKDTQYDIKLLCHLMIIRLANSNGAALLENITLLLEPLRVILMTKVNETAVKQQIERNEECIRSALRAVASISRIPNSDSIVKFEEFVKNTIRTTPLAAQFNSILSEDTMSNQDSMDTSN
The following text describes a protein:
Function:
Electroneutral K(+)/H(+) efflux antiporter involved in K(+) homeostasis and osmotic adjustment. Together with KEA5 and KEA6, promotes growth and development, and facilitates endosomal pH and ions homeostasis, as well as salt tolerance (e.g. K(+), NaCl and LiCl), probably by supporting cell wall biosynthesis during rapid etiolated seedling growth.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MRRCKNNTDKFSVITMRLLTLLLICTFFFFFSFAYSAESDNETDSVVTREINGTVVESNATSAKPREDSFADMIDRALEKEFPDNDQNEVPDPGSFNNSVADQQAVLETVARVKPKKNETKTKEEKSFFNLDNENGVEDTPRLIDRKDNVFIMSNPKSKYPVLQLDLRLISDLVVVIVSATCGGIAFACAGQPVITGYLLAGSIIGPGGLSFVSEMVQVETVAQFGVIFLLFALGLEFSAAKLRVVRAVAIPGGLLQIFLFMCLSGITASLCGGKLTEGIFVGAFLSMSSTAVVLKFLMERNSISALHGQITVGTLILQDCAVGLLFALLPVLGGTSGVLQGVLSMAKSLAILIAFLGALFVLSRTWVPWFLKLMTSLSSQTNELYQLAAVAFCLLVAWCSDKLGLSLELGSFAAGVMISTTDLAQHTLEQVEPIRNFFAALFLASIGMLIHMHFLWNHVDILLAAVLLVIVIKTVVVAIVVKVFGYNNKTAVLVGMSLAQIGEFAFVLLSRASNLHLIESKLYLLLLGTTALSLVTTPLLFKLIPAVVHLGVLLRWFSPDSSTEIGFKGELYHSESAKRISLMIQGSLHDS
The following text describes a protein:
Function:
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity).
Sequence:
MSLLEFFRPQKKTSASVAKERLQIIVAERRSQNDPAPSYLPQLKEDILKVIAKYVAIDPSMVELSFEHKGDDISVLELNVKLPDDEK
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MTDISERNKLILEAIIEDYITTAEPVGSRAVTKRHGLTLSPATVRNVMADLEEMGYLVSPHTSAGRVPTDKAYRLYVDSLLAVRRIDKVERERIRKRYAEAGRDIGAVLHETSRLLSSVSHYTGIVLAPRFSATIFRHIEFVKLGGRRILVILVADNGTVQNRLIESDEEFSSEELIRMSNYLNELLVGVPVGQVRTRILEEMRNEKVLYDKLLARALQLSEQSLNDDGAQIFIEGQTNILEQPEFADSRRMRDLFRAFEEKNQLVGLLDRCLNAQGVQIFIGAETHLSQMEGLSIITSTYLTGKNTLGVLGVIGPTRMGYAKVIPIVDYTAKLVSRLLEGE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MASTEEIVQMMQEASAEFAEADDVSFLDKMNSNIAQLEQQLREQMDESRQNIAKLEINLIDTEKSIGSLRELMKDATDEATIMKGSDKLNNLIDELQATENEIQMMNSEIEKKVSKLVEDEDNTSSEYEMISKELEQEYDPVFASNILKLKLYRSLGVRLDLDNNQILIQNKELGTIDTLPLEDELTEFFKVKYIWSRIGK
The following text describes a protein:
Function:
Putative oxidoreductase.
Sequence:
MAARINTVLVIGGTAGIGEQLVRRFHGLGKKVIVTGRNQEKLKELAEQLIGLETRAFDITDITSLTSNTQEILASFPTLDTVIINAGIQKSFSLFDPTSISATSIALEISTNLTAPALLVQAFAPHLLSLALQGTQTTLFITSSSLAYVPLGFYPTYCASKAGIHALALALRQQLGFQAAEAQRNMRVVEIVPPYTDTGLDREHREATVAMQGGPEKAFPAMPLNEFVDGFFQALEQGDADGGPKKEIGVGFGQVGVDVWRGSLGKVYEGWGLST
The following text describes a protein:
Function:
Required for biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKFSKIKKVQEEESAHQKMEWEAAGAKDSSSDDSSDESDNDDQPKQATEETRKRAELWTNRERVLVLCSRGADVRTRYLMKDIKDLLPHAKGDSKLDQQKSLNVLNEIAEMKNCTKVMYFESRKRKDTYLWMSNVEKGPSIKFLVHNVHTMKELKMSGNCLRASRPVLSFDDAFDKKPQLKLIKAVLMQTLGTPHHHPRSQPFVDHVFNFSVGEGDKIWFRNFQIVDESLQLQEVGPRFVLEMVRLFAGSFEGAVLYDNPNYVSPNVIRREHRKGQHSYIEKQLAVKASNIKQAKVTEILAEKTVDLVGKEFDTQNNAAADSEAAAQITAQIEKRRVRKKKSQASKYTGSD
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGQHVPGVEQTNGHLAEQGNPYQRSNSSRRRGGNRGGASKSWRTRNVDSQKSIGDEGLTVSTDKDTAEGSAEVDRQQEEVVKMVEELAASNVGEKEGALGKNQGASTSYEKDSGDSVFEIRGLVEPMLGEEERAANEEEQQDEVMVLESIFATDFQQTSSDPTTFELLVHVALPAAHIQVLGRLLDSGPSSTLDSLSQPEASNTDETSDFAREEEGESATAQAGEVSEAAAEEKETNGKEPPRGQIWVAKSWQGGRLLSLTLEHLPPLRLTCTLPAAYPSHSPPRFALSSVWLTRPQLGRLCRGLDEVWQENQGQVVVYSWADWLTRETFETLDLGESFELGGTLNAEGKGKESAEHDERAQAEGWGVQDVLSRLLRYNEEKTMEEFRKGVHECQVCFAEQPGTEFVHLWPGCRHNFCRGCMTSLVDIHVKEGSLARLTCPDTDCKEPLPPNIIKDLLAPEQFQRWETLMLQKTFDSMSDVVYCPRCETATIEEPDHTAQCQKCFFAFCSLCDDATHFGSQCMDAEAQLAVLRERTRGRLPAEEQKRKEAALLNEILNMKYVEREAKKCPKCGMAIQKDEGCNKMTCWNCSSYFCYKCGKAISGYDHFNSGACVLFEAAEIDAWNRMMAGVNAPRNEARDRIDAQIQMYPNRVRACPACRQPNVKEAGNNHLRCWSCQNHFCGACGKAVLKGSHHFGPKGCKQHTPD
The following text describes a protein:
Function:
Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Recycles between endoplasmic reticulum and Golgi.
Sequence:
MMVSLKSSLFFMLALLTVVHALNFDIPAKTNPEPFCLREYVGEKNLVIVNLKTTGNMGDGQTLSMMITDSSGNTHSSIQNVLGEKSVAFDVDASAMLDICFLNTLTPGAIESEHKKRSVKLEFTVGADADDYSSLQKANNLEPVEADIRRARDFIEEIKGKIYYLQAREARFRNTNESTNERVKNFAYLTFISLFVLVIWQILYLRSFFQRKHLIP
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNSNDANGEQCSTTEGMLELDNLKFNAARNVNGHHQAGDDTYANDNDNGDYIDDGGDSSSDDEQISSSFHHAPLHQNSDSSVDQLRTYFLGHVFNPNTDQLSMLSFQKQLYWLTYRSDLTVPLRPYNGGVGLKSDAGWGCMLRSAQMMMAQTVRMHYEGSSGEGCCGSGGVKHQSEGSRGSAVGGKGVEVERIACWFADFPNHFDINDDEEDEATDDVSNQQQQRRLLGYRYGDGGLHHHWYSLHQMVAAGLGLGVLPGEWYGPTTACHVLRELNEIHCGCRERVAEVLKRRRKGGDKGDIDEHNHVGDDSQYTCDVFRVHIATEGCIYLDAISKLMTSSNQSLQTESNDAPIQHNTDSAANVIDHPLSLPEEVFDPLRAQVTTQSSDKEQILNQQWDTSLLLLLPLRLGIQSIPTPTYGSTLAKLLSFPQSVGMLGGTPRHALWFYGADEVDPPTFGDDGKALNGQECGGWYGLDPHTTQVAPRGTRTTKYGKDEVSSDDIELNNCQWQVQLNDAYLRSLHFTPTTTHANHQRSIPLSKLDPSCALGFYIRDHSDFVQFTNAIDALSKEHCRPNKLPDIVTVTEKTPNYEVDVGSVMKTLMLCGKGTTKEREGGRGDETCNDDCGGGSDNQLDGFSMDSEEGVLSEEDDDDDYVLI
The following text describes a protein:
Function:
[NPLP1-4]: Acts as a ligand for the receptor-type guanylate cyclase Gyc76C. Stimulates Gyc76c-dependent cGMP production and modulates the IMD innate immune pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Does not appear to play a role in Gyc76C-mediated wing development.
Subcellular Localization:
Secreted.
Sequence:
MQAVLQSAHSSRRLMLLLSMLLNAAIQPRSIIVSATDDVANVSPCEMESLINQLMSPSPEYQLHASALRNQLKNLLRERQLAVGEEQPLGEYPDYLEEDKRSVAALAAQGLLNAPKRSLATLAKNGQLPTAEPGEDYGDADSGEPSEQKRYIGSLARAGGLMTYGKRNVGTLARDFQLPIPNGKRNIATMARLQSAPSTHRDPKRNVAAVARYNSQHGHIQRAGAEKRNLGALKSSPVHGVQQKREDEEMLLPAAAPDYADPMQSYWWYPSYAGYADLDWNDYRRAEKRFLGRVLPPTRATASTHRSRL
The following text describes a protein:
Function:
Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.
Sequence:
MKCVLVATEGAEVLFYWTDEEFAESLRLKLQQSEDEEEELPVLEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENDNHLYVLHLFGEYLFVAINGDHSESEGDLRRKLCVLKYLFEVHFGLVTVDGQLIRKELRPPDLEERARVWKHFQRLLGTYSYLRDREQSFAVEAVERLIHPQLCEQSIETLERHVVQAINASPERGGEEVLHAFLLVHCKLLAFYSGHGASTLRPADLLALILLVQDLQPSPGTTEEEEEEEDSDSPQRRPKSSQNIPVQQARSQSTSVPTRSSRETDTDSISLPEEYFTPAPSPGDQSSGSLVWLDGGTPPSDALQMAEDTPEGLASHSPELPSPRRIFLDANIKENYCPLVPHTMYCLPLWPGINMVLLTKSPSTPLALILYQLLDGFSLLEKKLKEGQEAGSALRSQPFVADLRQKMDKFIKNRVGQEIQNTWLEFKSKAFSRSEPGSSWELLQVCGKLKRQLCVIYRLSFLVTAPSRGGPHLPQHLQDRAQKLMKERLLDWKDFLLVKSRRNVTMVSYLEDFPGLVHFIYVDRTTGQMVAPSLSPNEKMSSELGKGPLAAFVKAKVWALVRLARRYLQKGCTTLLFQEGDFRCSYFLWFENDMGYKLQMIEVPVLSDDSVPIGVLGGDYYRKLLRYYSKSHPSEPVRCYELLTLHLSVIPTDLLVQQASQLARRLGEASRVTLP
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MFMINVLLLIIPILLAVAFLTLVERKILGYMQLRKGPNIVGPYGLLQPIADALKLFIKEPLQPLTSSTSMFIIAPILALTLALTMWIPLPMPYPLINMNLGILFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLSTLIITQEYLWLIFPSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFLAEYANIIMMNIFTTTLFLGAFHSPYLPELYSINFTMKTLLLTCSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPIMLSSIPPQT
The following text describes a protein:
Function:
Involved in the biosynthesis of the disaccharide D-N-acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage. Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc-pyrophosphoryl-decaprenyl (GlcNAc-PP-C50).
Miscellaneous:
MISCELLANEOUS: Mycobacteria use decaprenyl phosphate (C50-P) as a lipid carrier in all known cell wall biosynthetic pathways, rather than the usual undecaprenyl phosphate (C55-P) usually used in Gram-negative bacteria.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITYFATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGLAMFLGIVGAVFLASQLPALTRGFVYSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPVGGVGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHGGDVLYYPPAVISVVLAGACLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQNAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRAGRSAFSPDKMHLHHRLLQIGHSHRRVVLIIYLWVGIVAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYYDPDLD
The following text describes a protein:
Function:
Critical for growth under fluctuating-light conditions. Involved in the regulation of the cyclic electron flow (CEF) around Photosystem I. Essential for the reduction of PGRL1A by ferredoxin and for photoprotection. Contributes to maximize photosynthesis efficiency after a long dark adaptation via the regulation of non-photochemical quenching (NPQ); acts independently from DLDG1. Promotes the induction of steady-state proton motive force (pmf) and energy-dependent quenching (qE).
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Sequence:
MAAASISAIGCNQTLIGTSFYGGWGSSISGEDYQTMLSKTVAPPQQARVSRKAIRAVPMMKNVNEGKGLFAPLVVVTRNLVGKKRFNQLRGKAIALHSQVITEFCKSIGADAKQRQGLIRLAKKNGERLGFLA
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPETPEEKKFRIQQGVVKRLAKEHKSYIDETNKGVAEIAAMRATEGHDEYVLKKMVERNEESRAMIGDACRRLSVACADLATAMEALGKGEDDEGVKAAKELLESSRIQVECGAM
The following text describes a protein:
Function:
Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation.
Sequence:
MSCKVRLMEDGSLDEEPLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLDDSVIRLFEDTHRTSLKIVNLRNSTLSSIGLETLMRHKLFALSLWYCDMISVGSHHLLAHYGDSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNGVVMHHRLQFAHLHDLGHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQLHAICCLRRLCTLDISISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSPKMEQHFALTDIPGLASRTQRPLQFLGLYHTAHWACKRHDIPALEVAGDANEQQILTAARYYHDRPVLLTRVLNDLYHLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSKTEQEGFVQRIAIYLLNTLACQVDGRQKLFLGELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNVTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSREHVLERMVAAIQRWNIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCKLVEQENGIQILNELIEHESPYCEIKRIARLVIEQCDSGSERMVVDG
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MWGVFLLYVSMKMGGTTGQNIDQPTEMTATEGAIVQINCTYQTSGFNGLFWYQQHAGEAPTFLSYNVLDGLEEKGRFSSFLSRSKGYSYLLLKELQMKDSASYLCA
The following text describes a protein:
Function:
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEVSASEELFAFVKDLTDDRDALVARSREVLRSLGRSDDRVSASNVHSSLPVALQILRKTAVLEIHSPSARNALSGKMMAELADIVALLENPEVHGKLNAVVLRGTGGWFCAGADLRVAQQELTSPEAGAAMGALMVDTLTRFRRLPLVSIACIEGGAYGGGAELATACDFRVLESKAVIQFVQVRMGVSPAWGGGARLYKIVGRQNALRLLCTAEKLSGQRALELKLADFTFDAESDGADAAICSFAFPFDGIAPAVSHGAKRVINHADDVSLDAVLSYEHDVFKSLWGGPANLEALEGALEKKKQ
The following text describes a protein:
Function:
Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MELDHTPPPSVLNDNCSASYMTPYATVIAMSGLYLLAIFYFCKKSKKMCQPMSDSIYPYQKRLTQLERELKNYLIDEESIEVDDFQIGQTADGFIFRGGVFPKTRNRFNAKVTTAVKISFPIVSKSISLLEDALRLSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTRNVLVTEPDLRKCEVKLGDFGDAPMGLEYSTPIIAYMPPEILCCAERIPPHRPENDVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCLSEPHMRPRFASTTNASITSRLSELHHIVSPALFLYAIPNQSVCTCIEHHCQSVIHY
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Sequence:
MCSAIHLHIGGAGVMIGNELWKLYQKEQTETNVKSYIYNENETNYFPLTLFMDLDDRMVNEVKKNKLINYKTNSFVTGKEDAANNYCRAHYTIGKEIVDKCLDNIRKQVESVDRIDQFIITSALSGGTGSGFTSLLLERLSVEYGAKVDKNAFLIYPSKEISNNTVDAFNAVLATHVTIEHCDSVVMLDNESMYKSIDEQIGLDYVDYTHLNNLVSQIISSYTGLRRFCNIDNSKLFTGLCPYPRVHFVIPSYGPLASINDYNNKELTEKQLISQITKQSLRLFQSEIHPEHICASLVHRSKYHNQFFGQQDLTLQKMKIKNQDSPNVFECLSANYTTIPELAQLKQTGIFLSNDASLFNYFELLGKKYDYVYAKRAFVHWFVGEGCESGEMSECREDLAALSKDYEELTEGALKFCEMLEEDDQE
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reductive condensation between pyruvic acid and the side chain amino group of L-ornithine to form N(5)-(L-1-carboxyethyl)-L-ornithine. To a lesser extent, can also use L-lysine as substrate (yielding N(6)-(L-1-carboxyethyl)-L-lysine). NADH cannot replace NADPH in the condensation reaction.
Miscellaneous:
MISCELLANEOUS: No enzyme activity is detectable in the reverse direction with NADP(+) and chemically synthesized N(5)-(L-1-carboxyethyl)-L-ornithine as potential substrates.
Sequence:
MKIGLVKANFPGERRVPLLPKDIKDFKNEILVEEGFGKFLDIDDQEYSDKGCHILSRAEVFAESEAIFSLKLIQPTDYYHLREGQMIIGWTHPFGSGQSFMKEQALPKKLIVVDLDSNSPCIYYENEIFESGIPKGLLYKNSFYAGYAGVLDALLQYGLIPTEETKIAILGSGNVAQGAFSSISKYSSNIRMYYRKTMSIFKENYTKYDIIINGIEIGKDDDPILSFSEQKSLKKGTLIIDVAADAGNTIEGSHFTSIDAPIYENAGKYYYVVPNTPSLIYRNVSQELSKILSENIFRKDCSRFIEKVKPLNK
The following text describes a protein:
Function:
Channel-forming protein essential for import of protein precursors into mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MSIPTEKPAGPSAFTPYLDAVANVFHPVSGPVLNTYAKFHGWKENMGLVQPGTVENLTRDAQQVQLANWMFDGARADVAKVISGNPAFQLTHSFSLGSTTRPAAYNFGVIFANAKTFLQGGLDGSGSLTMRANQTWSARDLSKIQAQVTDKPGHTMVQFEHDHIGDHYTFSWKSINPNLLDFTGIHMASLLHSVSPRLSLGFETVIQYPEPAILQTATSYVAKLTSLPNPVAALTPTTPGLPSPFVPSWIATGHLQPDGNVQATYYQKLSDKVDVALDFQTILRPQSMLGPAKREALTTLAAKYDFRMATFRGQIDSAGKVGMYLEQRFTPAFAFLVAGEIDHAKNASKFGVGIMIESSTMTQEEMIAAGMLTPV
The following text describes a protein:
Function:
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, P-body.
Sequence:
MGGGERYNIPDRPAPKKSQPVSRGKQRSRDQNGVMHSAASGALGVPHHLRRGEKGTSYSWSPEARQAVSVDKKNGSVRFATPYDQNWESHLNKLLSAQCGQNYAGAKFSEPPSPSVLPKPPSHWVSLPMGDHRELMTFQLKSLLKVQA