lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MEYLLFLLLFAGFLTFLPRFLIYAQITSSTTTTTPVPAANRRTIRVGVAAVQTTELDSIGWPMSGGAINMAIQKLRDDGFIAPFDFEVTVNYTECDRSLGAAVGMEFMRTKRLDVVIGPPCRDPMEIMATMATYYSTPMLGWGLVTDSKFTDTERYPYLTNIMANSLSLGFSLVKLLEMMEWDRVALVYEESAQDYPLSVINDVETAINEYDTFAVNVVVKQALPGGDLNDAQYISVLNRIKLRCRIIVSVFQTAPTRRRYLKMIDQQGMANEEYVHILLGLRSIGFGKQSAGLTKCELNCLSSGLAPFWDIAPDDGLNDRLKQAATRMLVMDLSTDVPDINYLNTFTMNCGAVVVNPPVSCATPACINASTSPPSAFARSLHDVFYLYGLAITNLYNQDPAYLNDIDKINGALQLNFAGLTGEVSINANNSRVPKLMLYALNDKYDQASFMNLTYSLNGGAVSVSLAYTNEASLWYWYGGKRPLSVPVCGFAGTDCPQSFVDQYGALVFAIGGVLIFAMLFVITCFFYVMRQKRLERDRIDAEWQIPLVKLQAPPKRDKERMSKRSLQSGPSNITDTSKMTFDNTFSNYSIFYLDKEPVLSTAHPASNLIRTDYDTFVRLRKLDHENVNKFVGMSIDGPEYLAVWKLCMRGSLQDIIGQGNFSIDPFFMFCVIRDMAEGLKYLHNSFLHVHANLRSGTVLVNESWQAKLTDFGLGTLAEEKKPMKRRQLWMAPEVIRGTLLPHQIEKSADIYSLAVIASEVLTRKEAWNMAERKDTVDEIVYRIKKGGPNAPRPELDMDGVEINHNLLILIRDCWSEEPADRPSADVICNLLKNMMPKKGNLMDHVFNILEDYTTNLEVEVEDRTKELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPHLPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHIHLSAASYTLLMKHYPNQYNTASRGDVIIKGKGVMETFWVFERNNQFMGVSSNSGYQSDKKATNNGSSPESTPPSTPPMHEVKANSPVRHRKPPSPSSPTLSKRSVSPIMEAKARDIHNEETEALYRQFRRQETLALI
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MDGNARGSGHSDALKNYNLGKTLGLGTFGKVIIAEHKLTRQKVAIKILNRSQMGAMEMEEKANREIKILRLFIHFIHPHIIRVYEVIETPKDIFVVMEYCNNGDLLDYIVEKGRLHEYEARRIFQQIISGVEYCHRNMVVHPDLKP
The following text describes a protein:
Function:
Transcription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata.
Subcellular Localization:
Nucleus.
Sequence:
MSHIAVERNRRRQMNEHLKSLRSLTPCFYIKRGDQASIIGGVIEFIKELQQLVQVLESKKRRKTLNRPSFPYDHQTIEPSSLGAATTRVPFSRIENVMTTSTFKEVGACCNSPHANVEAKISGSNVVLRVVSRRIVGQLVKIISVLEKLSFQVLHLNISSMEETVLYFFVVKIGLECHLSLEELTLEVQKSFVSDEVIVSTN
The following text describes a protein:
Function:
Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.
Miscellaneous:
MISCELLANEOUS: Phosphinothricin tripeptide (PTT) herbicide and fosfomycin antibiotic biosynthesis pathways share early steps starting with phosphoenolpyruvate before the pathways diverge after formation of 2-hydroxyethylphosphonate (HEP). HppE is involved in fosfomycin biosynthesis after divergence of the 2 pathways.
Sequence:
MSNTKTASTGFAELLKDRREQVKMDHAALASLLGETPETVAAWENGEGGELTLTQLGRIAHVLGTSIGALTPPAGNDLDDGVIIQMPDERPILKGVRDNVDYYVYNCLVRTKRAPSLVPLVVDVLTDNPDDAKFNSGHAGNEFLFVLEGEIHMKWGDKENPKEALLPTGASMFVEEHVPHAFTAAKGTGSAKLIAVNF
The following text describes a protein:
Function:
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFSNIVNKKLFQNSTTTSFLRHYSTIKNTTTSPKGFKTGTYACGLKKSGALDICLIHSEKECNVAAVFTENKVKAAPVLLSKSLIEKHKNTGFQSLIINSGGANACTGPEGEKNAQTMSFLSSKLVNAKQQSLVMSTGIIGQQLDMKKVELGITKASENLKDDWLSAAKAIMTTDKVPKLVQKQIEIQGKQVNITGICKGAGMIHPNMATMLCTLCTDADISEEALKSALKHSIDYSFNSINVDGDMSTNDTVAVFSNGLAGNKRIDSTNSKEYLLLEKAMRECATELAQMIVRDAEGATKFISVVVRGAKTEKDGKIIANSIATSSLVKTAMYGEDANWGRVLAAVGYSGADGVVPSNISMWFASGYGDNIGIGQKNDPLIAMQFLKDGQPTPKDDEKAAKLLSNKDISIIVDLNNGNQNYTMWTCDLTVDYVKANSHYRT
The following text describes a protein:
Function:
Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.
Sequence:
MRGLISALVLTLVGSQHLNYQPDFGENKVYTYNYESILLSGIPEKGLARTGIRIRSEVEISGIGPKLCLIRIHSIEAAEYNGIWPTSSFSRSLKLTQALTGQLSIPIKFEYSNGHVGNLMAPDSVSDDGLNIYRGILNILELSLKKMQHSYSIQEAGIGGICNTTYAIQENKKANLVDVTKSKDLNSCEEKVQVVTGSAYTQPCQTCQQRNKNSRATATYNYKIKYTHNEAVITQAEVEEVHQFTPFHEITGGNAIVEARQKLALIEVQKQVAEVPPKEFQKRGSLQYQFGSELLQLPVHLFKIKDVERQIEERLQDLVETTYEQLPSDAPAKALKLMHLLRAANEENYESVWKQFSSRPAYRRYLLDLLPAAASHRSLRFLRHKMERQELTNWEIAQTVLVALHSSSPTQEVMEEATLIVKKHCPRSSSVLRKVCLLSYASLCHKRCSSPYSCSECLQVFHVFAGEALGKSNIEEVLLALKALGNVGHPASIKHIKKFLPGYAAGASELPLKVHETAVMALKSIGMRDPKMVQAITLEIFLNHKIHPRIRMLAAVVLLETKPGLPILMILVDAVLKEPSMQVASFIYSHLRALGRSTAPDLQMMASACRMAVRALSPKFDRSGYQFSKVFRFSMFKEFLMSGLAAKYFVLNNAGSLIPTMAVSQLRTRFLGRVADPIEVGIAAEGLQEMFVRGYSPDKDWETNYDFREILKKLSDWKALPRDKPFASGYLKMFGQELLFGRLDKDTLQNVLQVWYGPDEKIPSIRRLISSLQTGIGRQWTKALLLSEIRCIVPTCVGFPMETSFYYSSVTKVAGNVQAQITPSPRSDFRLTELLNSNVRLRSKMSLSMAKHMTFVIGINTNMIQAGLEAHTKVNAHVPVNVVATIQMKEKSIKAEIPPCKEETNLIIVSSKTFAVTRNIEDLAASKMTPVLLPEAVPDIMKMSFDSDSASGETDNIRDRQSVEDVSSGNSFSFGHPSSGKEPFIQSMCSNASTFGVQVCIEKKSVHAAFIRNVPLYNAIGEHALRMSFKPVYSDVPIEKIQVTIQAGDQAPTKMVRLVTFEDPERQESSRKEVMKRVKKILDDTDNQATRNSRSSSSSASSISESSESTTSTPSSSDSDNRASQGDPQINLKSRQSKANEKKFYPFGDSSSSGSSSSSSSSSSSSSDSSSSSRSSSSSDSSSSSSSSSSSSSSKSKSSSRSSKSNRSSSSSNSKDSSSSSSKSNSKGSSSSSSKASGTRQKAKKQSKTTSFPHASAAEGERSVHEQKQETQSSSSSSSRASSNSRSTSSSTSSSSESSGVSHRQWKQDREAETKRVKSQFNSHSSYDIPNEWETYLPKVYRLRFRSAHTHWHSGHRTSSSSSSSSSESGSSHSNSSSSDSSSRRSHMSDSSSSSSSHRHGEKAAHSSRRSPTSRAASAHHRPGSSLTRERNFLGDVIPPGITIVAQAVRSDNRNQGYQATAYVRSDAAKVDVQLVVVQLAETNWKACADAVILPLKAQARMRWGKECRDYRIAALATTGQMARKLAVQLKVQWGIIPSWIKKTSTALMRYVPGVALVLGFSEAHQRNPSRELIVRAVATSPRSIDTVIKVPGVTLYYQGLRVPFTLPLGPSSSSYETRDITAWNFLPEIASQIAQEDQSTCEVSKGDFKTFDRMSFTCSFNKSCNVVVAQDCTEHPKFIITTRKVDHQSLSREVHINTSSANITICPAADSSLLVTCNKESVLSDSGVSEYEKDNIKIYKNGKTVIVEAPIHGLKNVNFDGEILKVTVASWMRGKTCGVCGNNDREKHNELLMPNHKLAHSCSAFVHSWVLLEETCSGGCKLQRSYVKLNRNPTIDGEESTCYSVDPVLKCMKDCTPIEKTSVKVGFHCFPKATAVSLLEWQRSSDKKSASEDVVESVDADIDCTCTGDCS
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MKPEDLPLYKSPIEVTRIEKPESKLPMETQVAQAREFITEYSVPVVKALNTTSTFVSNGVGRVTTQYDSINDKPALLQKSAFIGGSFASGWLLNSLLFPKSGRIRRILTPVTCAAITASICYPDQTTQLLNDARYNIKKQACFIYRKFKGTPPESCTKQLEVKNEEN
The following text describes a protein:
Function:
Likely to act as a downstream effector of Cdc42 during dorsal closure, acting in a kinase independent manner with the other ACK family member Ack to positively regulate expression of the myosin zip by promoting the endocytosis of Egfr in the amnioserosa (AS).
Sequence:
MEYPQIDLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFDHVNNKNEITEMSAKLGQKSGDTNGNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPFPKKKNFTEELQSIPDIQSLIGKEGLEAYNSLIERKALLDIGPSPAATLLRHLDTDEFDLQSLHQSQRPMTLPTRGATQRVRKAELAAGLSRHNDENSNSLEACESPSYMTHGSYKFPEAQPTEQLPEPESPNPIPLPPREGKKQVKTSTKRHVRKYPLIIPANGLQRTLSKLADFGDEAAKSPEISTSSQPQPGRAIEVVAAVRPSGMRRPSRPSEREYENMPTVGKESAHTYQNLDKLTPADAAGLTDTASLQFESIMEADTSKEGILQSPDVTDGFYNFSIQKEHYNKGKDAEFEATQISGLYVNDDELRNLDIESSRRTATPCSSCSALESEHSQPDALPSTESVSEVSRFSSVDNELAGNALFKKVRASVNMAMNRKSVAETSLTSNQPGGASAKPQTEAEYFAATAARLADSNSVSCEDLLEFSDKKPKGCERGVDSDEVRIMVKVLGKDSTPNRCLGALEFINWDVHKSIKLIKLQNLVSEANLSLEASFEALQQHEWDLHTTAHKLNGLKL
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MERDCVVKIPSMVLVFLSIQHEKQNTVIYRLRTVFNQLVSDIGSPVDFELPDSLNKWNSTSYTKIRRNVYLTKKVKRRLEDDGIFCSCCSSAESSGVCGKDCLCGMLMSSCSSGCKCGISCLNKPFHQRPVKKIKTVQTEKCGMGVVAEEDINQGEFVIEYVGEVIDDKTCEERLWKMKHRGETNFYLCEINRDMVIDATYKGNKSRYINHSCCPNTEMQKWMIDGETRIAIFATRDIKKGEHLTYDYKFVQFGADQDCHCGAVGCRQKLGVKPNKPKTASSDAALQIIARQVAANSPKVKGLVSNKH
The following text describes a protein:
Function:
Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.
Sequence:
MRFSRQEHWSGLPFPPPGNLLYPRIEPESLVSPALAGGFFIIAPPGKPRFFQIYEKVQLLTMLESNDSVFSLDNLFFEKTDEAENHLDSEISMDWFLPPAPLISEIPDTQALEEEIENHQLLGQNKKSKMLPSNLKITNEDINYVLQTQKFQFDFPSNEYEEDDLNLGGAGNNDLHVAGKLTCGSSQKWKNHIGTEIELEKNVPDDTKLVNSAQDKGVSMSAFRKRLFKISDNIHEDGYSNDSANLDSNTGSVKIVQTEVNKGKSWKDSNSKQKPQYSDCNILTATDTLFASEIREGIIKAPLFPVASQPHTVQGVTEKSLDSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWSNIKIVYMAPIKALCSQRFDDWKKKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVHLVRLFLIDEVHVVKDENRGPTLEVVVSRMKTVQILSPAVENTNSIIPMRFVAVSATIPNAEDIAEWLSDGERSAVCLKMDERHRPVKLRKVVLGFPSSDNQTEFKFDLTLNYKIASIIQTYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKCAYSIKDSKLRDILIHGVAYHHAGMELSDRKVVEGAFTVGDIPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGMFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTKEKYIQMLACSDTIESSLHRHLIEHLNAEIVLHTITNVNIALEWIRSTLLYIRALKNPSHYGFASGLNKDGIESKLQELCLKNLNDLSSLNLIKMDEDINFKPTEAGRLMAWYYITFETVKKFCTMSGKETLSDLVTMIASCKEFLDVQLRINEKKALNTLNKDPNRTTIRFPMEGRIKTREMKVNCLIQAQLGCIPVQDFALTQDTAKIFRNGSRITRWLSDFVATQEKFAVLLNSLILAKCFRCKLWENSPHVSKQLEKIGITLSNAMVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELEVEQITRYSDTMAEILVTVILRNFEQLQTKRTASNSHYVTLIIGDADNQLVFKHKIMDSVLLKAGNWAKKFDVRRALKSENLSINLISSEYVGLDIQRKFTVFYSGPKRFGNQIIIQKKSETEISHSEHSDRSTVAGPKKGMTACKKPGNRECNHHCKNKHTCGHDCCKTGVAQKSEGKESTISSYLSDLRNRNAVSSLPPVKRLKMQMNKSPSVDLKDFGFAPKPSLPSIARSEYLNTPELPIMEQRDQHEIYTKSQQQPSAYQDKEVLKVNFELGNEIWDDFDDENLVEITSFSAETEKTKTSGFGNTLSSSTGESKLPFQESKGQFQRESSKSFVSSHEKPDIYLSNSAVSKFGASSMTQLPQQSGNASIVHLQERKQQSLSPEIEKLCFTRSEKISNSSNFNEKVDCFIRNECKKEIDFSRYHPDDEADEIKSFLGIFDGIF
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Sequence:
MGTTTATKKNEQSSSTLVIGTNDSSIVSKRSAERLGYFHQTQFLKHFVLKPQRRTSLINIGYTIRTLLIDLLIKRFLEADSPDLTNPEEPTTTTTSTPIVIVNLGCGYDPGFFKLASNQNGSLLNANRSVRYIDVDYPELISKKYQMISRSEELSSILPGFDKSRVGDWIELSNRNASYTLLGCDLCDSHGFINKLIESLDGSNNQQILFISEVSTVYMPSDKSDQLIKNLSQSFPNMIWSCLEQVLPSTPTAFSDTMMKHFHKLRTPIRGTLAYPTISDQIKRLGSHWKRVEMSTIHDLWKAFDHNQSTRTEKERLMNLEAFDEWEELDLFLSHYLVGIAYSKPGLMERTTRLQDDGTMSLPQLRDRSPTTTDHALGSHGSGRHGLPWSYSSVESSIQRRGHTSTLLPDGHLLVFGGFGLPNPIKSVDQKLKSSPSAHSRLAHPILLSPRASSVQITPLPIDPSTPSARLYHTASPLVNGDDQTSSVFLFGGRSSPRAPLADAYVFNCTTNTWNSVKPSAAESSWPPPRFRHTALTLQIGNSSYVLIHGGIGSEGVILKDTWLFDPNRNLWIALNDMDKFIGPRHSHQIYYDPFDQELYVFGGITAICDGEETSRLGRNVKFGLTFEKDLVVKLRPDGPELLDFKCDDALLHRYSHRIATWDQQNKTLLMSGGISENGVITTENQYILLNLKSRTSHLLQLHQQKTQTMIGHTMTIIDLFQKGGNQPGLKAALVIGGGATCFSFGSSFDISIQIISDSDLSLVEDTESIENNRGELKRKCNGTFDDSAEDTWDKAQELPRIDKLTSRSWMDIVSAAKPVVFDSREEIGECVGRWTADYLKLKCGEKKCSVHLSNPLSSSTLKWHDKNFKYETMSFKELIDRTIGAGRSGVESNDRHQIAYLRSLSHSPKHPSNFHTDFLEISQDFKIPPVVNDYIVERDAFFSSVLRISGADMGLWAHYDTYDNILVQVNGKKLVRLWHPREVVNLYIEGSSSHIPCFDPPDLDRFPLYRKSHPMVCVLNPGDVLFIPANWIHAVQTIEPSISINTFFKTDRLERFYESKKKDIWGNLDLAPYHELHERVFKELLLDPHLPDHQHPAPGSSRFNLLPIDQRQFYLKKIAVDLIRHADQLTQ
The following text describes a protein:
Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
Sequence:
MPEPQEGETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLESGKELFIKIIPNKEAGTLTLIDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADKVVVTSKNNDDEQYVWESSAGGSFTVRPDSGEPLGRGTKIVLHIKEDQLEYLEESKIKQIVNKHSQFIGYPIKLLVEKEREKEVSDDEAEEEKKEEKEEKKDDEPKLEDAEDDEDKKDKKKKTVKVKYTEDEELNKTKPIWTRNADDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLDFRALLFVPRRMPFDLFENKKKKNNIKLYVRRVFIMDNCEELIPDYLNFIKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEELAEDKETYKKFYDQFSKNLKLGVHEDSQNRQKLADLLRFNTSASGDEYCSLNDYVGRMKENQTQIYFITGESIDQVKNSAFVERVKKRGFEVIYMTEPIDEYVIQQLKEYKGKQLVSVTKEGLELPEDEAEKKKREEDKAKFENLCKVMKSVLESKVEKVMVSNRLVDSPCCIVTSQYGWSANMERIMKAQALRDSSAMGYMAGKKHLEINPDHAIIETLRQRAEADKNDKAVKDLVILLFETALLSSGFSLDEPGTHASRIYRMIKLGLGIDEDEPMTTEESSSGAAAAAPASGDAPPLVDDSEDLSHMEEVD
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular Localization:
Nucleus.
Sequence:
MENIYCPRTEKVISVWDALAEFQNELHPERLDRIVESDHDIMEAMGLDGNIAEFDKLLESVDVGQLSSSKDVPVRTFLPHKVCSRPKPAETPAKAARFNCVQRVTARKSVKDQRNIDVKLRYNRHKYMERKQDLETRKDLTPFREMVLVVRFYEPFKYKAGRRLGHPKFSQEYYVLSSQYLTELKDKIFCHCDAGPFYEISGDRTAEPTEKPPKSGFFFVHDTFYNDFRDDANHDYSGVIRKWADRQSLIGELKTARMEDTRFGDLKFRLGYPQMYQHQGNCEHLFVISDCRLLAATDILTRSRYPWLNSYGFSRDVPCNICGHCQAQYIVQNSTRHIFDPAYICENCLETYHYTEDGEKIGDFELHRYTLTMVRTDEDADSEEASTSQ
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLLLGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASLISGIIFALIGVFVGRRIAGIQQRKGLQEK
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSMLVNLVTNFDMSIVLTASCAFVFILYYWYKRPRNFPPGPRGIPLLGMVPFLGKHTEKDFRKWSKKYGPMMSVRLGQNDWIVLGDHKTINECLVKGGNSFSGRPDHPVFKQVTKNHGVAMVDYGDHWKVQRRFGLTTLRGFGVGKRGMEDRIVEEIAYLNNAIRSNNGKPFDIAELMANGVSNNISSIVMGQRMDYNDEIFKTLSKKAPNRLYLVTYSWLYVYNSDTIGKITKLVLYMPFLRNLLFLFLSKPKEAIVNWVSQHKSTYDEHNVRDFIDAFIGEQKKETDVSFTDLQLIQYVRDLYVAGTETTTGTLRWAVLCLVHHPEKQNKLRKEIFDVIGREKTPSMKDKAQMPYTCAFMQELFRFRTLAPLGVPHKISNDVQVQGWSIPKGTWLVCNLWAVHNDPDVWDEPSKFKPERHLDEKGNFVQSKYVMPFSVGPRHCLGEQLARMEIFIFLVSMVQKFEFLPDPNEPRLSEVQQGVSGFMCVPHPFKQIAKEV
The following text describes a protein:
Function:
Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associated fat body.
Subcellular Localization:
Nucleus.
Sequence:
MMATSQDYFGNPYALFRGPPTTLRPRESPLGVGHPHGHGHLHSHAHAHGHGHAHSHYAALDLQTPHKRNIETDVRAPPPPLPPPPLPLPPASPRYNTDQGAMDQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKLRDSAASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNNSSSNNNNSSSNRERNNSGERERERERERERDRDRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQDSQANFKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGLSQSLSIKQELMDAQQQQQHREHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADARDEHNDAKQLQLDQTDNIDGRVKCFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEEMKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYNCEYKCKELNMRAIRCSRQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANNQAYLASNGAVQQLDLSTYHGHANHQLHQHPPSATHPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASGSATSAPASVATSAVSPQPSSSSTGSTSSAAAVAAAAAAAANRRDHNIDYSTLFVQLSGTLPTLYRCVSCNKIVSNRWHHANIHRPQSHECPVCGQKFTRRDNMKAHCKIKHADIKDRFFSHYVHM
The following text describes a protein:
Function:
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRTKASGCTERRPLQPQTEAAEAAAPAGRALGFRDTLDAACLCGAMPSESNCVKLRSDRARPSLPWYPRAQSKMRRPSLLLKDILKCILLVFGVWILYILKLNYTTEECDMKKMHYVDPDRIKRAQKYAQQVLQKECRPHFAKRSMAQLFGPRYSTDLPPFVTKAPLGSKAESKYDPPFGFRKFSSKVQALLELLPEHDFPEHLTAKSCRRCVVIGSGGILHGLELGPALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKNETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDNLCMAAMNFQTMHNVTTETRFLLKLVREGVVRDLSGGIHCEF
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MEYAGQHIHTSFSPSQNKAKEVLSKEEPNFRGKIWLMLVVLLRMAVVVLAGYPLYQDEQERFVCNTLQPGCSNVCYDLFSPISHFRFWLIHTVSILLPYTAFSIYVLHKVATHIVRKHCLVYGCRGNKGLSSPRDLKELCRSDLVNRLDCDVDSLSVLNFSGAYTVHLFFRTLIEAAFAAAQYFLFGFFVPERFSCYHSPCTSTVDCYISRPTEKSIMMVFIWSVTSLSFLLSLADLVCALRQMTARSQRNKQLANPHRENEGLLNNPPAQSGSSSPPQTQDCPALNGSQTSDGSCSLLSEEEEEATLHPEEVSQQAASTNLNSNSHKPCASGDLAVKQDSIEEPLCADDQQGTACQQVRPGLQQSFVKDTALTLRPQIKSHLGGSSSVVHSKLLGYYPSAELKNPDAQSNYSSTSCLRSKKSEWV
The following text describes a protein:
Function:
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
Sequence:
MNNDFILTEFARVINSDRYQYTESDIFLMENMQNKVAVFDMFFRKTEDGGFAVVSGVQEVIHLIEVLNTTSEEEKKKYFSKILEEEHLINFLSKMKFTGDLYAIQDGEIVYPNEPVITIKAPLIQAKILETPILNIMNMNMAISTKASMVTRAAEPIKVLAFGSRRAHGFDSAVEGNKAAIIGGCYGHSNLVTEYKYGIPSNGTMSHSYIQAFGVGAEAEKEAFVTFIKHRRQRKNNSLILLVDTYDTIHIGIENAIKAFKECGINDSYEGVYGVRLDSGDLAYQSKKCRKRFDEEGFTKAKITLTNSLDEQLIRSLREQGACVDMYGVGDAIAVSKSYPCFGGVYKIVELDEEPLIKISGDVIKISNPGFKEVYRIFDKEGFAYADLISLVKNDSDKEKLLNNDELMIRDEKYEFKNSILKKDEYTYKKLTKIYIKDGIIDRTSYEDLFDITKSQKHYFDSLAKISPERKRLENPHSYKVDLSSDLINLKYSLINKIKNV
The following text describes a protein:
Function:
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
Subcellular Localization:
Virion. Host cytoplasm.
Domain:
This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half; The coiled coil region is critical for homooligomerization, for the interaction with VP35 and for NP function in RNA synthesis; Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Nucleoprotein contains one L domain: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101.
Sequence:
MDLHSLLELGTKPTAPHVRNKKVILFDTNHQVSICNQIIDAINSGIDLGDLLEGGLLTLCVEHYYNSDKDKFNTSPVAKYLRDAGYEFDVIKNADATRFLDVSPNEPHYSPLILALKTLESTESQRGRIGLFLSFCSLFLPKLVVGDRASIEKALRQVTVHQEQGIVTYPNHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLVTGHDAYDSIISNSVGQTRFSGLLIVKTVLEFILQKTDSGVTLHPLVRTSKVKNEVASFKQALSNLARHGEYAPFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAHDAEVKLQRRHEHQEIQAIAEDDEERKILEQFHLQKTEITHSQTLAVLSQKREKLARLAAEIENNIVEDQGFKQSQNRVSQSFLNDPTPVEVTVQARPMNRPTALPPPVDDKIEHESTEDSSSSSSFVDLNDPFALLNEDEDTLDDSVMIPGTTSREFQGIPEPPRQSQDLNNSQGKQEDESTNRIKKQFLRYQELPPVQEDDESEYTTDSQESIDQPGSDNEQGVDLPPPPLYAQEKRQDPIQHPAANPQDPFGSIGDVNGDILEPIRSPSSPSAPQEDTRMREAYELSPDFTNDEDNQQNWPQRVVTKKGRTFLYPNDLLQTNPPESLITALVEEYQNPVSAKELQADWPDMSFDERRHVAMNL
The following text describes a protein:
Function:
Probable transcription factor that binds to the DNA sequence 5'-CAAT[AT]ATTG-3'.
Subcellular Localization:
Nucleus.
Sequence:
MDGEEDSEWMMMDVGGKGGKGGGGGGAADRKKRFSEEQIKSLESMFATQTKLEPRQKLQLARELGLQPRQVAIWFQNKRARWKSKQLEREYSALRDDYDALLCSYESLKKEKLALIKQLEKLAEMLQEPRGKYGDNAGDDARSGGVAGMKKEEFVGAGGAATLYSSAEGGGTTTTTTAKLMPHFGSDDVDAGLFLRPSSQHHPPPPHAGAGFTSSEPAADHQSFNFHSSWPSSTEQTCSSTPWWEFESE
The following text describes a protein:
Function:
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MRLLKFLWWTCVTLICGVLLSFSGAYLYLSPSLPSVEALRNVQLQIPLKVYSEDGKLISEFGEMRRTPIRFADIPQDFIHALLSAEDDNFANHYGVDVKSLMRAAAQLLKSGHIQTGGSTITMQVAKNYFLTNERSFSRKINEILLALQIERQLTKDEILELYVNKIYLGNRAYGIEAAAQVYYGKPIKDLSLAEMAMIAGLPKAPSRYNPLVNPTRSTERRNWILERMLKLGFIDQQRYQAAVEEPINASYHVQTPELNAPYIAEMARAEMVGRYGSEAYTEGYKVITTVRSDLQNAASQSVRDGLIDYDQRHGYRGPETRLPGQTRDAWLKHLGQQRSIGGLEPAIVTQVEKSGIMVMTRDGKEEAVTWDSMKWARPFLSNNSMGPMPRQPADVAQAGDQIRVQRQEDGTLRFVQIPAAQSALISLDPKDGAIRSLVGGFSFEQSNYNRAIQAKRQPGSSFKPFIYSAALDNGFTAASLVNDAPIVFVDEYLDKVWRPKNDTNTFLGPIPLREALYKSRNMVSIRVLQGLGIERAISYITKFGFQRDELPRNFSLALGTATVTPMEIAGAWSVFANGGYKVNPYVIERIESRDGQVLYQANPPRVPVEEQVAADAEDAGNPGDPEHPESAEGEGSIEAQQVAAKAQTTFEPTPAERIIDARTAYIMTSMLQDVIKRGTGRRALALKRTDLAGKTGTTNDSKDGWFSGYNSDYVTSVWVGFDQPETLGRREYGGTVALPIWIRYMGFALKDKPMHTMAEPPGIVSLRIDPVTGRSAAPGTPGAYFEMFKNEDTPPSVNELPPGSFPGSPLPDDEGAPIDLF