lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine, glycine and beta-alanine. Also contributes to L-alanine uptake. In addition, in minimal media, transports the broad spectrum antibiotic D-cycloserine into the cell. Transports D-cycloserine only in minimal media, and not in a complex medium, suggesting that CycA does not play a role in D-cycloserine transport when E.coli is grown in a complex or biologically relevant medium, probably due to competition from other CycA substrates present in the medium.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKDPEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCWVCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
The following text describes a protein:
Function:
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFALLDTGISQLIRLIVE
The following text describes a protein:
Function:
Processively dephosphorylates 'Ser-5' but not 'Ser-2' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II. Together with CPL1, required for male gametes fertility. Multifunctional regulator that modulates plant growth, stress, and phytohormones responses. Positive transcription regulator of genes involved in high salinity resistance and auxin mediated signaling pathway. Prevents the accumulation of intronic heterochromatin-containing genes (e.g. IBM1, At3g05410 and RPP7). Recruited at histone H3 lysine 27 trimethylation (H3K27me3) marks and low-methylated H3K4 by the BAH-PHD bivalent histone reader complex to form a BAH-PHD-CPL2 complex (BPC) in order to silence several H3K27me3 and low-methylated H3K4 enriched loci, including AGO5, via the phosphorylation state-dependent inhibition of Pol II release from the transcriptional start site (e.g. Ser5P-Pol II dephosphorylation). The BPC complex represses flowering by inhibiting the expression of several genes, including AGL6, FT, FUL and SOC1.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MNRLGHKSVVYHGDLRLGELDVNHVSSSHEFRFPNDEIRIHHLSPAGERCPPLAILQTIASFAVRCKLESSAPVKSQELMHLHAVCFHELKTAVVMLGDEEIHLVAMPSKEKKFPCFWCFSVPSGLYDSCLRMLNTRCLSIVFDLDETLIVANTMKSFEDRIEALKSWISREMDPVRINGMSAELKRYMDDRMLLKQYIDNDYAFDNGVLLKAQPEEVRPTSDGQEKVCRPVIRLPEKNTVLTRIKPEIRDTSVLVKLRPAWEELRSYLTAKTRKRFEVYVCTMAERDYALEMWRLLDPEAHLISLKELRDRIVCVKPDAKKSLLSVFNGGICHPKMAMVIDDRMKVWEDKDQPRVHVVSAYLPYYAPQAETALVVPHLCVARNVACNVRGYFFKEFDESLMSSISLVYYEDDVENLPPSPDVSNYVVIEDPGFASNGNINAPPINEGMCGGEVERRLNQAAAADHSTLPATSNAEQKPETPKPQIAVIPNNASTATAAALLPSHKPSLLGAPRRDGFTFSDGGRPLMMRPGVDIRNQNFNQPPILAKIPMQPPSSSMHSPGGWLVDDENRPSFPGRPSGLYPSQFPHGTPGSAPVGPFAHPSHLRSEEVAMDDDLKRQNPSRQTTEGGISQNHLVSNGREHHTDGGKSNGGQSHLFVSALQEIGRRCGSKVEFRTVISTNKELQFSVEVLFTGEKIGIGMAKTKKDAHQQAAENALRSLAEKYVAHVAPLARETEKGPENDNGFLWESSEDVSNKGLEEEAPKENISEL
The following text describes a protein:
Function:
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion matrix.
Sequence:
MAAPMAKRALVMKFSIGCLKQNNLPNFLSIRALCQTRPERKSLVPALFLNLKSGLHSDGSSNNGQCENIVTSKKNGDATDAVKAFSVPGQPAAARVVTVAIVGAPNSGKSTLTNRLMGRRVCPVSSKVHTTRRKTLAVLTEGDTQVVFLDTPGFTNTSKAGRHHLENTMVKDPKASMLEADLIAVMVDPTERQSQKKLKWDLRKALYTLPKPIPAVLILNKTDLMRHKTKLLEIAAKLTTGVVGGEPIQITEAKKRLIPELSPLEAALIKAQKKKVLSEKKEECVQTDTEERLRVRNTVDSEAREPKEKTIDAVTSSEDTIDKPTQSQESDLSAKTHGVDKCEQLQSTVEAHIRDSMTDASVVEERDIHKRDSKTTDSEMMYDKGYVAEDGLDGATKEEMKMALGYDVDAWDRIVEERDKTVKRQKSKDPEKTALHQEISRQCGWPGFQEVFMMSAKEGQGVDNFKDYLLSMAKPGDWQYSPDFLTDQSEHEIAYHAIREKLLEYLPQEVPYNIQQEVEMWQEGEGGDLQIVIQLIVSKSTQVPMLIGPKGATIKKIAKEAAQEMEDTFFTDVFLKLGVKYAGLQK
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MLVRLSGSIVHARKLNRSWQTLDRGPSSGGEDCWIGWPRRLSGGPVRVLGIECSCDDSCASIVGSDKRILSNVRLSQNDVHKAFNGIHPYHAIHAHQINLPIAIGRALKEAGLKLTELDGIAYTRGPGIAGCLAVGATAAKSLAIATGIPLLAVHHMQAHALTPFLTQTHDEIEFPFLSLLVSGGHTMLVLVKSTSEFKILANTADKPLGLAIDKISRALDVPWPEGSASPGSALEMFVNEGDADELAGEEEAALPLALRTGPSVFSFCGLQTATIRRLAAHPDRHPSTAHKRKIGRAFFDAAFGQIERKLRHWIHQLSSTHPEKLKGLVISGGVGSNQILRDRVEKLLKSIDPELKLHIPPISFCTDNAAMVAWTGIDKLARGKTSGMDVSVAAKWSIEDAEDESAGIMT
The following text describes a protein:
Function:
Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the centriole lumen.
Sequence:
MPVRFRGLSEYKRNFRWKTPELCSPSQEQKSPWAGLRSDQLGITREPNFISKRRVPYHNPQISKSFEWTGDCDSDDPVETEALKTAESLAEHSNDVNQENTETPEGPRLPPKVRSHSSDSGVETALALAGNSMKKTPPVAPPNQKEAFVSPKKEAEKVNNGLHRVLQRKGGMNTPHLSTFPRNSEYQSQFVWKSPHEKSPILAAEEALYNTKREELIQKPAEDASKQEKSEQKHPKRKNKQHISQKPLSLHTHRGKMNTEYRSKFLSPAQYFYKDGAWSRIRSKVPNQASQNPLNSMWYMEVRELRARAKAYRQRIEGTHFSRYHLNQLLSDNNSLWDVSSNSSSEEGISNDIRALDLAGVSEKETAPRPKMLQQPGSREQSHQDDTEKKGLSDAPTVPVKRRLVWGEQEGTAEKDSQQLREEEEKENEQAAVVTQNLEKNNEGINEDNRIEGENTCLPNSPAAVSESSSVSSEPGGRLPTPKLRALGRAQRTHHDLTTPAVGGAVLVSPPKFKSSTSQQRMRSLGTDPSSVGQGAREASQRRSFRPGAKLKAVSLLTSPPAGLGTVDPLPLRQDQWHPNGVSGETVAINSAYQERSSTPPVLKSTKNRPMPCWSPSPRIQGTLKDPEFQHNGNVGNPKMGSFQLPLQERNYNNEDDRLSQISARSAASSSLASQILERAQKRKEDFWGKT
The following text describes a protein:
Function:
One of the few RNases that cleaves the phosphodiester bond between any two nucleotide. Shows a preference for cytidylic or guanylic acid.
Subcellular Localization:
Periplasm. Cytoplasm. Note=RNase I (periplasmic) and RNase I* (cytoplasmic) appear to be isoforms apparently encoded by the same gene. The cytoplasmic form is less active towards natural polymer RNA.
Sequence:
MKAFWRNAALLAVSLLPFSSANALALQAKQYGDFDRYVLALSWQTGFCQSQHDRNRNERDECRLQTETTNKADFLTVHGLWPGLPKSVAARGVDERRWMRFGCATRPIPNLPEARASRMCSSPETGLSLETAAKLSEVMPGAGGRSCLERYEYAKHGACFGFDPDAYFGTMVRLNQEIKESEAGKFLADNYGKTVSRRDFDAAFAKSWGKENVKAVKLTCQGNPAYLTEIQISIKADAINAPLSANSFLPQPHPGNCGKTFVIDKAGY
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (By similarity). Enables the organism to utilize D-amino acids as a source of nutrients (By similarity).
Subcellular Localization:
Cytoplasm. Secreted, cell wall.
Sequence:
MAIGEQQVIVIGAGVSGLTSAICLAEAGWPVRVWAAALPQQTTSAVAGAVWGPRPKEPVAKVRGWIEQSLHVFRDLAKDPATGVRMTPALSVGDRIETGAMPPGLELIPDVRPADPADVPGGFRAGFHATLPMIDMPQYLDCLTQRLAATGCEIETRPLRSLAEAAEAAPIVINCAGLGARELAGDATVWPRFGQHVVLTNPGLEQLFIERTGGSEWICYFAHPQRVVCGGISIPGRWDPTPEPEITERILQRCRRIQPRLAEAAVIETITGLRPDRPSVRVEAEPIGRALCIHNYGHGGDGVTLSWGCAREVVNLVGGG
The following text describes a protein:
Function:
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate.
Subcellular Localization:
Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
Sequence:
MAGARAAAAAASAGSSASSGNQPPQELGLGELLEEFSRTQYRAKDGSGTGGSKVERIEKRCLELFGRDYCFSVIPNTNGDICGHYPRHIVFLEYESSEKEKDTFESTVQVSKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYGRSGYNYFFSGGADDAWADVEDVTEEDCALRSGDTHLFDKVRGYDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDYGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNSCLLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFARGVGLRSISSNAL
The following text describes a protein:
Function:
Microtubule-associated protein probably involved in the regulation of microtubule organization.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Colocalizes with cortical microtubules and binds directly to microtubules.
Sequence:
MLPNGEDDSDLLRLVKELQAYLVRNDKLEKENHELRQEVARLRAQVSNLKSHENERKSMLWKKLQSSYDGSNTDGSNLKAPESVKSNTKGQEVRNPNPKPTIQGQSTATKPPPPPPLPSKRTLGKRSVRRAPEVVEFYRALTKRESHMGNKINQNGVLSPAFNRNMIGEIENRSKYLSDIKSDTDRHRDHIHILISKVEAATFTDISEVETFVKWIDEELSSLVDERAVLKHFPKWPERKVDSLREAACNYKRPKNLGNEILSFKDNPKDSLTQALQRIQSLQDRLEESVNNTEKMRDSTGKRYKDFQIPWEWMLDTGLIGQLKYSSLRLAQEYMKRIAKELESNGSGKEGNLMLQGVRFAYTIHQFAGGFDGETLSIFHELKKITTGETRG
The following text describes a protein:
Function:
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Also catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside GB4, thereby synthesizing the glycolipid GB5, also known as the stage-specific embryonic antigen-3 (SSEA-3).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAHMKTRLVYASILMMGALCLYFSMDSFRELPFVFKKSHGKFLQIPDIDCKQKPPFLVLLVTSSHKQLAARMAIRKTWGRETSVQGQQVRTFFLLGTSDSTEEMDATTLESEQHRDIIQKDFKDAYFNLTLKTMMGMEWVYHFCPQTAYVMKTDSDMFVNVGYLTELLLKKNKTTRFFTGYIKPHDFPIRQKFNKWFVSKFEYPWDRYPPFCSGTGYVFSSDVAIQVYNVSESVPFIKLEDVFVGLCLAKLKIRPEELHTKQTFFPGGLRFSVCRFQKIVACHFMKPQDLLTYWQALENSKEQDCPAV
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MYIEDPAEIAAIATEFISNLDNLPQEVSHMVKEIEHKDAQIQELLSKVTAREAQLKEILQKGGSGLSNPAGSLPEADRIKAEKLTDKIRSDYGRADEWSSQKEALSLRLWRAIHAHQKHLKEEMNKISPAVLSNYASTASIGTPVVPSLSALPAALAGLKSPAVEMESPLAGLKRKGSLLSPGVGTLIPGTPMSAAARARAGGRTTPLDSGSPAPPERGLGGAIRGGGASRKARGGSLSASGPGRSGLSQSTELGGLGGLEGFEGEGGEGEEGEEKDDTPYCFCQRVSFGEMIGCDNAENDPDCKEWFHIGCVGVTKPLPQKWYCSECLAKLKNKRRRQ
The following text describes a protein:
Function:
Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Acts as a CO(2) chemosensor and induces CO(2)-mediated filamentation. Essential for pathological growth in niches where sufficient CO(2) is not supplied by the host. Necessary for white-to-opaque switching at low CO(2) concentrations.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion intermembrane space.
Sequence:
MGRENILKYQLEHDHESDLVTEKDQSLLLDNNNNLNGMNNTIKTHPVRVSSGNHNNFPFTLSSESTLQDFLNNNKFFVDSIKHNHGNQIFDLNGQGQSPHTLWIGCSDSRAGDQCLATLPGEIFVHRNIANIVNANDISSQGVIQFAIDVLKVKKIIVCGHTDCGGIWASLSKKKIGGVLDLWLNPVRHIRAANLKLLEEYNQDPKLKAKKLAELNVISSVTALKRHPSASVALKKNEIEVWGMLYDVATGYLSQVEIPQDEFEDLFHVHDEHDEEEYNPH
The following text describes a protein:
Function:
Has a role in sporulation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associates with the microtubule cytoskeleton.
Sequence:
MLARPETDTSVDYYAILKLQKNATFQQIRKQYLFLALQYHPDRNPGDEERAVKRFQRLQLAHEVLSDATKRLIYDQLFGLSTRTRSQYKPNSTSNPSKHTSAYASYNKGKNSKWSSPFASTTKKPQESSEKYSKKSSTRKKEHFNKKPSFPRDTEYSHIYNMKYDPRSGIGIRVKRQEPESLKKENNNSDYLPKSAMKQKKGGPKDSSKHPSNDGKIPESKPSVYKSRASNLFSSNEQSIHSSFGSKFHFDKSSNPFSFEFSPSSNAAKPSNSEECNIPKFNSSFKTSNDFFTFTKTEESSPYSFSFKLEDSNTPKFKSSSKPVKSSFVFTKPEAESSNPFSFDFGSSGPKSRSDTRNNIRTPLWTSSVFEKPESDLPNKTAFGFMRSNTSTFNQKCDDFSSASFMKEKTEFEEQLQEDNDHSLGDLFSKINISTESPSVAMPSIPVIQPPSFPIFSSIDFNVRNREYWNQLMVFQKLYSKYCTESQHFINSWINIKKELHIVPVNWEIFEKVEKSWDQCEEFVAEFRQTEEKYFLFLKRLRELINKNQML
The following text describes a protein:
Function:
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.
Sequence:
MKPINVGLLGIGTVGGGTYTVLTRNQEGNRAPCRPPNCHHARRDRNLELARKVTGGQIDVTDDAFAVVVRPRHRHRGRIDRRIHHRARTGYEGDRERQARVAANKALMLAWQRDFRRVAQQKGVIVAFEAAVAGGIPIIKAVAAGAGRQPSSRVLRAIINGTTNFILSEMREKGLAFADVLKEAQPRLCEATRPSTSRAWTAHKLMILAAIGFGIPMQFDKAYVEGISKLDALDIRYAEELGYRQAAWHAPSAPARGVELARAPDPDPRETPDRQCQRRHNAVLVSDACRSHLVYRPDACRRHASAVVADIVDGTRTAYHRRAPAVPHLLSSPTSSWTCRFAIGEVSSAYYLRLRAVDKPGRDGHVTRILATGSLHRCDDSEGNRRQAERRRSGRHHHPDHVTVEKNMDDAIVAIEALPAISGSVTRLRMEELSR
The following text describes a protein:
Function:
Interacts strongly with CDK4 and CDK6 and inhibits them.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLLEEVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDILQGHMMIPM
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVKPSKNKLTKQQKSKQYRPPGKRKEGNVAKYTTRNKALNRLQIKLPEFRRLCILKGIHPREPKKKFEGHNKTYYHVKDINFLAHEPLLEKGRELKVYDRKIKKAKAKKNKELAQRFDRLRPAYSLDHLVKERYPSFIDALRDMDDPLTMLHLFATLPADNVHKIPVERVQIARRLSLEWQAYITRTHSLRKVFVSVKGIYYQADVTGQKITWLTPHVLSQVLPNDVDFRVMLTFVEFYETLVGFVNFKLYHALGLNYPPVIDERLEKATAGVEELMEVVNSEGTIEEQEDEETIRCKTLFKDFKIFLAREVPRDSLLFTIRAFGGTVSWDGDGAPIEESDETITHQIVDRPTQGHKFLSRDYVQPQWVYDCCNARILLPTDAYVLGRVPPPHLSPFVDNEAEGYIPEYGETIKRLQAASAKHVLPLPGAEEEMDDVNKSEEAAAIRRSEAAEIAAKEQQAMLLEKTYTEELSKEIAGVPYSSTLEEPEEKDAMSDDAQETRPPTMTPTGADDETATLAQMMMPKKTKKLYEAMQMGLGKKKASVELLKQRKKKADEKKSAKSQRA
The following text describes a protein:
Function:
Mediates influx of magnesium ions.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MITAYIYENRQLTVTEINIQDSIPASTIWLDLYKPDDAEREWLSHFSVEEVPDEEDINEIEASARFYQNSDGLHINSLFPQRVGQDVRGVNVSFNLRTNFLLTIREEDVGLIRLLRNYLRLGRLEVSTPQELFLELFNLKVDYLSDLIEDVYTVLENVGEQVFDSEELDDVFKLITLQEDSNGKIRLSLLDTQRSLRYMQRYYRGQLSDEHLKDLREMLSDIESLMPHSQFIFDKLNFLLDAAMGFSGLQQNKIIKIFSVAAVVFLPPTLIASSYGMNFNGMPELQWQYGYPMAILMMLASAAGTYFFFKRKHWL
The following text describes a protein:
Function:
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Subcellular Localization:
Cytoplasm.
Sequence:
MSLIETVPVNTEHKSVPVHLHSNLSGLSEEIAKLPGVTSVFLITEKSIHSIYSKYLERELSSLPIKTIYIKGGEKSKHINRTGEVYNQLIEYGADRKSLILAFGGGVVGDFAGFIASTYLRGIRFVQIPTTLLACVDSSVGGKVAVNADFGKNMIGSFYQPEFVFAPLSVLSTLPDREWKCGQAEIIKHSLLSGGEYWEKVKTHSFKDLNVDSTILPYLIAESVRFKANVVSSDEKETGLRKILNLGHTTAHAIESVTKYKKYSHGEAVAIGLVTALLLSEQHSELDPVTTKETIESLKNYGLPFQTKLKSKQLAKHMLHDKKNVGGSIRFVLLKSPGSPIFDIPINSEDIILAIHKQKGI
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRKGIYLRIALIAFTVILAIIFFLPNTPLFSYMPGWWKKNLPHKGIVLGLDLRGGSHLIFEVDLKRAREITVERIGMHLQSLLEKKGLKPSVKVQGEKIFIQPVNEDVKKIIKENYADLSISEHGGNIICELPETAFKRVETTSVEQAIEVIRNRIDQLGVAEPAIHKQGENEIVVQLPGVKDPKKALEIIGKTAQLEFKLLDEETTLWKQLPSLIKAGEEDTFLNQWKSKLPESDEIVFQKIVNKETGEVYKRPYIVKKDVLLTGDLLAEAHVSIDQRFNEPYVSLRFNDAGAKIFEDITGKYVKRRLAIILDGNLYSAPVIQEKIEGGNAQISGSFTLEEAKDLAIVLRAGALPAPVKLIQNVTVGPTLGKDSIEAGKMAVIIASIFVSLFMIIYYRLSGVIADFALILNIILLIGALAALNATLTLPGIAGIALAVGMAVDSNVLMFERIREELRLGKTPKAAIETGYKKAFWTIFDSHVTTLITAAVLFHFGSGPIKGFAVTLSLGVAINLFTALIGTKTVFDFIYIGKERKSLSI
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MEEEEIIEPKDFENEESENIQMDENEKQIPIQTTNDPQNKNIMRILVATDNHLGYLERDPIRGDDSFNSFEEILKYAHTLKVDMVLLGGDLFHDNKPSRSCLYRTMELFRKYCLGDSPVRIQFLSDQSVNFSNQFHTVNYEDPNFNISLPIFSIHGNHDDPTGEGGLAALDLLSVSNLVNYFGKTEDIDDITVYPLLLGKGETKIAIYGLGNIRDERLHRTFQKQSVKLMRPVESKDEWFNILVLHQNRVAHNPKNYVHEKMIESFIDFVLWGHEHECLVNPQASSVGEFHISQPGSSVATALSEGESKDKFVGLLEVYKNQFRFKPFPLNTVRPFIMDQIILANSNIHPTQQNDVIQWIEQKVESMIEQAKLKSQGKPNESMLPLIRLKVDYTGYSTINPQKFGQRFQGRVANPNDVLLFHRKKPTTLSSKKQKDGGELDVNSIKEKEEDKVKVADFISEFLGNTPNDRLQILSENDLFNSLHSFVEKDETDSILKMVDLSLKSTQKYLNSKISSKDAYPDFIAKYIDDNFPLPHQNVSSVNSDLLPINNPNEFESNLLDEDSHGHEHGHSHNHSQMIDNDDDENILNQRTIFKSPQSNKTAPTTTTTTTTTTSSQISTRRKSSTQSSTQSSQTSIIIDDDDDDDEINEDNDDNDKDFESDEEKTPPSKKRGKVKQVGSVSKRSRSKK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Miscellaneous:
MISCELLANEOUS: A cysteine residue is required for ubiquitin-thioester formation.
Sequence:
MSVQAYTNTPNLPNLIHSESITNSPVFIPNLRSKSDNKHRLNTSEELPFTKKRRATKHFLKMEVSAKISEPPSSKSVEFGRHLNMRHDFSELLEQPLTTSKTRVFKSFNEKLKGKPQLVKSDKGVLPLNKQSDILNSYERVLSNASVDSALDKKAEVDIIPFDKSVMEPKNITFNDKSGLTKFGNSNSYETTYSDSSNYHTSTDSSQYNDQDDHVYDDTNDGTDDDINNNEYKDDESSSGSESYERDEDVDEEEEEDDDENNDEGDDEDENENDELRSENGSPNPSAAVINEQENMNMSGIEEYDETNLLNELGRIRRGNQFQSLASSILSSGNLENSDDEDVSLGPQTYRFNSSFHPFRSAFSAPGVQFGRLLEGIKDFSDPTVQMLSLQELSEAFAMSTEDMLVGLFSTDSYIAAFSEILSGRNYDFGEVSIQLMLSCTTCVSNMMEALPLCMAKIAYSPIVRILCERMFDMQYIDIAEQALGVLERLSKDFGICILEHRGMLAALQYFDFFYTTVQRTAISLAANCCKFLDESNASAAEEIIPLLSNILQSSDTIVVSKAYSCLETIIESLKTSPNIIETIISEDLITTIVNALTNSTSQNKSMHLQVQLLHIISSLCQSSSALILPFLNHNLPDVMYEMLCGIPPSDTSHQADMITMQSLYYCPIELIENLLRAITSLLPKNTSNLSDEFNTKLYRLNSILLTVVMDIYFIVPLHDIRSLAVTTALKMLCSIRENNLDGLVCSLPLSSFIASILNSRKSDNFLKRDALEMCLFLLEALPNVYSSLFIREGVVQEVGFLVRSTNADMKKIKLSISFSQNKSAARHEELKNLSTLKSLAKEFLSNYKEENLENSTLVQLKQLSKHLLSETKQDESFSELAKIFQEGSNITSHELLHSGLIHNLLLSLKKFGSSSLRTFLLAMNTCDEREVLEFGNGPLVSLIFCLQNLLSTVENFQLSTLPPDTENAVDHVFSRQFKLRLMALPGSRIRPPFRSLVVSINGLATIRTLDNYLHSRISVRNETGRRFSILREAGSLRESMSGSSRNSSGDYTDSMSQDAPNHTTEPSERRDSSTSSHFEEHFVFSLMGKKVPRNKTIFRILYEYIQLSDDHTLDDFWKTPVPIFYGEPDCIHNDMKGELNYENETEGFSINIREILDLLSILYYGIRDVHTLFPDKHFRGNIENILTDFSNWKLSAKLNRQLEEQQLVVHGCLPSWCISLTSAYPFLVPFETRYLLLQSTAFGLSRSVSFLLSRNPELSKNESSSILQFVSLHRQKIRISRKKIFNYALHLLATYAASENILEIEYEDEVGSGLGPTLEFYTSVSKEFTLNSLDIWRNDQPNSKFVYQASGLFPSPIPLLGSSPENERKISLFFALGQFVARSIYDSRIISIQFNPLFFARNIPLTISSVAKVDKGLANSLRYLEKLIPGKNPTNAETDIKLEDLHLDFTLPGFPSIELIPDGASTPVTTFNVSDYLNYVIDYTVGKGVQQQLEAFQNGFSSVFPYTSLQVLTEHELVTLFGTVDEDWSYATLMKSIVADHGYTMESPTIQRLLTLMSQMNFQEQRDFLQFITGSRKLPIGGFAGLNPPLTVVRRLNEPPYVPDDYLPSVMTCVNYLKLPEYSSSEVLGSRLSKAILEGQGSFHLS
The following text describes a protein:
Function:
Natriuretic peptide that dose-dependently induces the rapid relaxation of rat aortic strips phenylephrine-precontracted. Acts by stimulating cGMP production in a dose-dependent manner (by probably activating NPR1 and/or NPR2). May also show potent hypotensive effects.
Miscellaneous:
MISCELLANEOUS: Negative results: does not inhibit platelet aggregation.
Subcellular Localization:
Secreted.
Sequence:
MVGLSRLAGGGLLLVLALLPLALDGKPAPEALHKPPTGLRTSLAALRILGYLRPDSKQSRAARDRMLHPEQQVGGGGDSRPLQDETNKGKGSSCFGQKIDRIGSMSGMGCRTQGKPPPALPTAPAALRILEYLRPDSKRSRATRDRMLHPEQQVGGGGGGGSRVI
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MRTKTGFSFFSKITYSKKKPSPTIPKKGLDSSEIDHTIDNAAEIIEKWNTEYVSTTKFYSLFCESKREAKKFINGVKDLQKSMDTLIKEDPNSENLLRAQKLMQIAMKRLQSEFYQILSMNRARLDPETGEDVRLAGDSIVEVEEVSRNSMKELKSIAECMIAAGYAKECASTYKCFRKSIVDEGIHRLGVEKVSSSKVKKMPSEVVEVKMRSWIDAVSVSMKTLFNGEKTLCDEVFEGCSVSLRESCFRDISKEGALLLLGFPESVAVRDKKTPNPKKIFTLLDMYGTITENLQAIESIFSFHSVSAVRSQALSSLNRLSESILSHLVEFESEIRKDSSKTVVPGGGVHPMTTSSMDHLSRLAEYSGILVNIIVKGSSSSAKALLPKSYFNLSESDGCHHGSEVRVRFAWMVLVLLCKIDGKAEMYKDFSMQYLFLANNLQHVASRARSTGLKHLLGDEWIERHFEKVGQFARSYERLAWEPLASMCPKTEEMSPEEAKMRLEKFSECFESTCQSQSACVVPDQTLLEEMRSSIVEKLLPVYRDFYNAHSNAAMLAGTEGGWNVRYTPEDVAKYLSSELFNGKGVLEEEKSCVFRTSFGLVTARNSSRRKKRSLSCRRF
The following text describes a protein:
Function:
High affinity, slow turnover Mn(2+) transporting ATPase, which is required for virulence. Controls the Mn(2+) cytoplasmic quota and is involved in the uploading of Mn(2+) into secreted metalloproteins. Required for tolerance to Zn(2+) and oxidative stress. Plays a crucial role in the ability to resist zinc poisoning in human macrophages. Shows a preference for Mn(2+), but Zn(2+), Co(2+) and Cu(2+) can act as alternative substrates although at slower turnover rates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTLEVVSDAAGRMRVKVDWVRCDSRRAVAVEEAVAKQNGVRVVHAYPRTGSVVVWYSPRRADRAAVLAAIKGAAHVAAELIPARAPHSAEIRNTDVLRMVIGGVALALLGVRRYVFARPPLLGTTGRTVATGVTIFTGYPFLRGALRSLRSGKAGTDALVSAATVASLILRENVVALTVLWLLNIGEYLQDLTLRRTRRAISELLRGNQDTAWVRLTDPSAGSDAATEIQVPIDTVQIGDEVVVHEHVAIPVDGEVVDGEAIVNQSAITGENLPVSVVVGTRVHAGSVVVRGRVVVRAHAVGNQTTIGRIISRVEEAQLDRAPIQTVGENFSRRFVPTSFIVSAIALLITGDVRRAMTMLLIACPCAVGLSTPTAISAAIGNGARRGILIKGGSHLEQAGRVDAIVFDKTGTLTVGRPVVTNIVAMHKDWEPEQVLAYAASSEIHSRHPLAEAVIRSTEERRISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLRAEKVRVSKKASEWVDKLRRQAETPLLLAVDGTLVGLISLRDEVRPEAAQVLTKLRANGIRRIVMLTGDHPEIAQVVADELGIDEWRAEVMPEDKLAAVRELQDDGYVVGMVGDGINDAPALAAADIGIAMGLAGTDVAVETADVALANDDLHRLLDVGDLGERAVDVIRQNYGMSIAVNAAGLLIGAGGALSPVLAAILHNASSVAVVANSSRLIRYRLDR
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Melanosome.
Sequence:
MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIKKANIPITDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEESSSLLDPSEVGRGTPLRLGFVAGVISRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMAAGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNVRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVADLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTAGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDVGHGILMTLFAVWMVIRESRILSQKSDNEMFSTIFSGRYIILLMGSFSIYTGLIYNDCFSKSLNMFGSSWSVRPMFTKENWTEDLLREYPVLQLDPASEGVFGGPYPFGIDPIWNIASNKLTFLNSFKMKMSVILGIIHMMFGVTLSLLNHIYFKKPLNIYLGFIPEIIFMSSLFGYLVILIFYKWTAYDAAISRDAPSLLIHFINMCLFTYYPNDKMLYSGQKGLQCFLVVVALLCVPWMLVAKPLVLRQQYLRRKHLEGQPEEPPVSPAQSPQAVEAAAAATGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSDEGEEPAMEEVFDFGDTVVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHVGLSVNSLAGGFGLFFVFAAFATLTVAILLVMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFDSICDGRFDE