lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLTRSSMSLSAHCYKSIFRVNPTLVRCSGPFTTEATSKKDNGKPENEETPEVAASEQEIKKLNETIAEFKDKYQRSLAETENVRSRLRKEIEDAKLFGIQAFCKDLITVADVMKMAVTSIPENELENETNKVWKSFYEGVCLTDKELHKVFDRHGLKLLEPEQGDKFDPYDHEALFEVPIDTLEPGSVAHVERIGYKLKGRTLRPAQVGVSRKAS
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHQWIALILLLCAAATRDQVKGTNDKALTKNGLEHVCDIAAEVRAKEHVHADGLTAAADKLAANQAVLAKVRILIAAASTAQEALQLQAISAALHRTAAEEEAKFTKATAMTAIEAIRHSSYLLGGLYEYLHIAGQAKDGTNNGCFADDENAGSFYTTEQLKNQVQNCKAVDLDEKAGWADKQVHKPDGYKRKTDKNNLWSTNAKGCKIHGGGNNNGPVESATYGANNHVAMGLISLSSTDAQLTDLSSLAGAEGDSKKRHAAKAFNTLSKPALKVNTIELPDKNALKNLANFDATLAAAVGASKPFSGQEKEQAMEKLYGSKDPDPTTMFWQKLKGLKLSTDSHGVTKGTKLDEIRNLPLLTELETNYTISKAIQRNSLAAADACNCPTAHPKPEEKLCNDATGDEGKCETLKEKGCIFDRNTKKCELNKDVKAQLEKANQETGGNDGKDTNTTGSNSIVIYKVSLLLAFILL
The following text describes a protein:
Function:
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Sequence:
MNASNPCRRFPRSARVRTRAQYTVVFDTARRTSDPLLSLHWRSGETPPRLGMAVSRKVDTRAVGRNRIKRVLRDAMRHLLPELAGGDYVIVARSAAAKATNPQIRDAFVRLLRRAGALPLPAAPGTMPPARAPRPSSLSPTEPDPRSD
The following text describes a protein:
Function:
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVAMAEAEAGVAVEVRGLPPAVPDELLTLYFENRRRSGGGPVLSWQRLGCGGVLTFREPADAERVLAQADHELHGAQLSLRPAPPRAPARLLLQGLPPGTTPQRLEQHVQALLRASGLPVQPCCALASPRPDRALVQLPKPLSEADVRVLEEQAQNLGLEGTLVSLARVPQARAVRVVGDGASVDLLLLELYLENERRSGGGPLEDLQRLPGPLGTVASFQQWQVAERVLQQEHRLQGSELSLVPHYDILEPEELAENTSGGDHPSTQGPRATKHALLRTGGLVTALQGAGTVTMGSGEEPGQSGASLRTGPMVQGRGIMTTGSGQEPGQSGTSLRTGPMGSLGQAEQVSSMPMGSLEHEGLVSLRPVGLQEQEGPMSLGPVGSAGPVETSKGLLGQEGLVEIAMDSPEQEGLVGPMEITMGSLEKAGPVSPGCVKLAGQEGLVEMVLLMEPGAMRFLQLYHEDLLAGLGDVALLPLEGPDMTGFRLCGAQASCQAAEEFLRSLLGSISCHVLCLEHPGSARFLLGPEGQHLLQGLEAQFQCVFGTERLATATLDTGLEEVDPTEALPVLPGNAHTLWTPDSTEEVRELLATLEGLDLDGEDWLPRELEEEGPQEQPEEEVTPGHEEEEPVAPSTVAPRWLEEEAALQLALHRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVEELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPARAARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPGRSPDT
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIRKIGIASRCDRPEVLQMVRDIIAHFYSKVQIYVSTATADVLDIEGTPVERMRDKGVELIISVGGDGTVLRNIAKMKDPLPVLGINMGTLGFLVDVEPEDAIETIEEVLYGFSYLERMRVDVFLNGEMLETATNEVAVMSAKPAKIIQFEVYVNDCLLDEMRADGVVFATPTGSTAYAMSAGGPIINPRVNAIVVVPVAPFKLSARPWVIPSDSEITVKLSDHKKEAVIAIDGQKSYRIRPDDVVKLKKSKYPARFVRISDTCFYERVQRKLS
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSYFRAFLNSPVGPKTTHFWGPMANWGFVISGVMDSQKPPDAISGNMTSGEIVVVFTFLVQTTRTMVDVSFLNAKENVSSRNNGGSSISLLCVYSLLCMRFAWMVRPRNYLLLACHASNESVQLYQLSRWLKHQRYVSQFTSA
The following text describes a protein:
Function:
8-amino-7-oxononanoate synthase; part of the cluster involved in the biosynthesis of biotin (also known as vitamin B8 or vitamin H), a water-soluble vitamin that functions as a prosthetic group of many carboxylases, such as acetyl-CoA carboxylase and pyruvate carboxylase. Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON) (By similarity).
Sequence:
MGDSPKCLRDSLREALRRREDKLCRRKLTILPSSSVDFSSNDFLSLSTSPAYRARFLDILQQAPPLHPFASGGSRLLDGNSAYAEELENFIAAFHNAPSGLLFNSGYDANVGVFSSIPQPGDLIVYDELIHASAHEGMRLSRAGKRIKFPHSSPDGLRAVLQAEITADPRLLQGRRNVFIAFESVYSMDGDVAPIREFVEIVDQLLPYGNGYFLVDEAHATGVFGPRGSGVVQELGLEDRMFVRVHTFGKALASHGAIVLCCADTRDYLINYARSLIYTTALGFPFLASIRAAYELLVEGKTEQLQHKLGQLIAHFRTGLDNLNHKDSSTFEVEHFTNSPIFSLRSSVPRVLASVCQEQGYTVRAIMPPTVPAGKERVRVCLHAGNTVEEVDGLLETIATWLQRMEKQKARL
The following text describes a protein:
Function:
Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives.
Sequence:
MSSRTVIRGGLVITASDEIHADVLIEDGRVAALAATGTPAAEAFTAENVIDASGKYVIPGGVDGHTHMEMPFGGTYAADTFETGTRAAAWGGTTTIVDFAIQSVGHSLREGLDAWHAKAEGNCAIDYGFHMIVSDVNQETLKEMDLLVEEGVTSFKQFMAYPGVFYSDDGQILRAMQRAAENGGLIMMHAENGIAIDVLVEQALARGETDPRFHGEVRKALLEAEATHRAIRLAQVAGAPLYVVHVSATEAVAELTRARDEGLPVFGETCPQYLFLSTDNLAEPDFEGAKYVCSTPLRPKEHQAALWRGLRTNDLQVVSTDHCPFCFSGQKELGRGDFSRIPNGMPGVENRMDLLHQAVVEGHIGRRRWIEIACATPARMFGLYPKKGTIAPGADADIVVYDPHAEQVISAETHHMNVDYSAYEGRRITGRVETVLSRGEPVVTEREYTGRKGHGAYTPRATCQYLT
The following text describes a protein:
Function:
Acts as a transcriptional activator of the acoABCL operon encoding the acetoin dehydrogenase complex.
Sequence:
MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPYLEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALDGHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCSAAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRFGERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGGTCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAARALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTLFLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIREDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNIRELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDMMIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES
The following text describes a protein:
Function:
Heptaketide hydrolyase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA. The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayp1 though chain-length shortening. 1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone. The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN. 1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone. Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN. Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin. DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize. DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins. DHN-melanin also plays a crucial role in fungal virulence, including a protective role against the host's immune defenses. DHN-melanin also protects conidia against amoeba predation.
Subcellular Localization:
Endosome.
Sequence:
MPRWILGDKFDTVFPHKGSLKVLWESRWKSACSKSVYPFHDGSIEDFEPIFNHLISKNINDAASDEYTQAFLPTASALEEKAAQALQAGKHEEASNLLCRAAVVYRISRFPYVDITKPSSIKRVAFERQKQAYLKATSLWTQPIREVTVPHTYRTGNDGAHIPIYIRTPAGADQSNPVPIVLIMTGLDGYRSDNSQRTHEILARGWAAVVAEIPGTADCPADPADPASPDRLWDSVLSYLDQRPELNTAKMVVWGLSAGGYYAIRAAHTHRDRLLGAIAHGPGCHYYLDPEWLAKVNDHEYPFEITAAWATKHGYKTVEEFVAGAQKKFSLVETGIVDQPSCRLLLLNGVDDGVVPIEDCLVLFEHGSPKEGRFYKGLPHMGYPNSLPVSYEWLEQVLASPSKTKN
The following text describes a protein:
Function:
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLLLQVALAFSGQQLLVSSAYAQDTAAPAAAEAPAAETAVPATDSAAAAAPAEDTANVAASAAKATEVVDNPYGLGALWAQGDFVAKGTLIILVIMSAFTWYIMVTKLWEQQRLISQAGAARRAWDAKSLGEGIQKLAKNSAYRAVAEDGLRAREHHDGKLTDNIALPEWVTSNVQRSVDGINSRMQGGLAFLATVGSTAPFVGLFGTVWGIYHALIAIGLAGQASIDKVAGPVGEALIMTAIGLAVAVPAVLGYNWLVRRSKVALEDLHAFAEDVQAYLVVGMRIAEEKKAGK
The following text describes a protein:
Function:
Probable substrate receptor of CRL4 E3 ligase complexes acting as negative regulators of thermotolerance by disturbing the action of HSP90-1 and by preventing the expression of heat-inducible genes (e.g. HSP14.7, HSP21, At2g03020 and WRKY28).
Sequence:
MGRNVKTKAKRKNKKKAEASSSEIPSIPTRVWQPGVDTLEDGEELQCDPSAYNSLHGFHVGWPCLSFDILGDKLGLNRTEFPHTLYMVAGTQAEKAAHNSIGLFKITNVSGKRRDVVPKTFGNGEDEDEDDEDDSDSDDDDGDEASKTPNIQVRRVAHHGCVNRIRAMPQNSHICVSWADSGHVQVWDMSSHLNALAESETEGKDGTSPVLNQAPLVNFSGHKDEGYAIDWSPATAGRLLSGDCKSMIHLWEPASGSWAVDPIPFAGHTASVEDLQWSPAEENVFASCSVDGSVAVWDIRLGKSPALSFKAHNADVNVISWNRLASCMLASGSDDGTFSIRDLRLIKGGDAVVAHFEYHKHPITSIEWSAHEASTLAVTSGDNQLTIWDLSLEKDEEEEAEFNAQTKELVNTPQDLPPQLLFVHQGQKDLKELHWHNQIPGMIISTAGDGFNILMPYNIQNTLPSELPA
The following text describes a protein:
Function:
Involved in 3'-UTR mediated RNA regulation. Binds to RNA-binding and RNA regulatory proteins. Complexes with PAB1-binding protein to promote mRNA interactions with poly(A)-binding protein. Promotes mating-type switching in mother cells by positively regulating HO expression.
Miscellaneous:
MISCELLANEOUS: Present with 3430 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol. Note=Localizes to polysomes in a PBP1-dependent manner.
Sequence:
MAIKSLESFLFERGLVGSYAIEALNNCTLDIDVNHYVSRLLTNKREQYLDAIGGFPTSLKMYLESDLKIFKDFNITPIFVFNGGLTYNQLEASGHFTAASASASISSTTTSSSGTNATTRSNTESVLLQRSRGWTQWNNLISSNQNSYIDQPIQPQEPFRHNTTIDSKAYQNDLIAYFIEHGYMYQVAPYSSWFQLAYLLNSAYIDAIYGPTDCLMLDCVDRFILGMEFPNKEFRFIDRSRVMKDLGCTHEEFIDIAMAVGNDLQPTTLPPLQIYPVPQLFDIALEMVLNTGTNFYAYQLSTTLQNDSKENIQNYQRGISALRYMPVLKDTGKVELFVQEIVVSEEDSEKNNKDGKKSNLSSPSSASSSASPATTVTKNASEKLTYEKSSTKEVRKPRDIPNDVHDFIGQMLPHEYYFYRSIGLVTGKLFDAIVTGVYPEEPPLGGGSSTSYKKLVSKSVEIFKNKEINLLTQPINRYYQIKQIKQVKWYAANEPTTLTNRMSPSMFETINHLIVKTETSDEKEFSISEFITTINGSSNMAKDFISEKVIFPNSVPIESKLNSPFNLLSTNFLRLLVLLEFFTFDFKEKLLEPTRWGEVFLKLNELNIDSKYHESVIIFLVFLKCDVLKLDEEVQPPAPSALSQATLRSYPEESLYVLLITRVLTLFQVDQKPSNYHGPIDKKTLIFRDHLSFIKENLNELFEAVLISSLTSGEFNRLSLDNFGWARKIVRYLPFKLDSPNTIMAMMWEFFLQKYLHNGNAKNDALSLVATEFNTYKSTPNLDEQFVESHRFLLEISKVMQELNAAKLIDENVFKLFTKAVEFTTTALSS
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQKNPQLGH
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGIFDFLSHAFDIPAFPWKSVVLAFTISRFLWERYLSKRQYKHYLNEKPPAVLASVVDEKKYKRAMQYARTKAHFGVLSSSFSFIISILIIRYNGFARLWNATDYSWMDRLATSNHWWSVSKAITHSCMFAFAGSVFSTIIDTPFSLYSTFVIEEKFGFNKTTMRTFWADIVKGLALGGVLLSIIIAIFLKVIIAFGDNFVVYVWVSFIVLGMVLQTIAPYVILPLFNKFTPVTDPELKSKIEELAASVKFPLKNLYIMDASRRSGHSNAFFYGMPWSKGIVLYDTLVKNQTTTELLAVLGHELGHWYMWHILIQQLVNYAVSFFHLALFAGFIRNNSMYSAFGFSGEHPILIGYLLFTSLFEPLSALISFGNNLLSRSCEYQADAFAKRLGYGDALAEGLIRLHEDNMSPLDFDRWFSAYHHNHPPLLERLEAIGYGAQTTDKTQ
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The AWS and SET domains are necessary for transcription repression.
Sequence:
MGDIIEGTKPTLDDLWAGDEDQKPQTPPVSPPRSPSFKHEHKSSFPGSTSPPPASPIGEEDLKPRTARASSSTSKVKSRKASPEEFKPVLIDDLPTAWDEAHETFEALEKCVYERKDIGLSKENDEMMVCECVYNRHDPDADPCGPDSDCINRALYIECIAGECRAGKHCHNQQFSKRQYANVDVVLTEKKGYGLRASSTIPANTLIYEYIGEVVAEKTFRKRMQQYADEGIRHFYFMMLQKEEYIDATKKGGIGRFANHSCNPNCEVQKWVVGRRLRMGIFTKRDVIKGEEITFNYNVDRYGHDAQTCYCGEPNCVGTIGGKTQTDIGTMNDLFLDALGITDEVEAMGMKGSKKKKSRQLDEDFVPILRPISAHEVQKVAAAIRQSMENKKMMSRLLQRIQMTDDGAMHRQLMRMHGFSLMYMVLTELADDNEIVLLALESMNKWKLQIRNKIEDSKIEEPVKALSQSGDEKICGLAKQLIEYWSTLELSYKIPRVSKIASLDADDEAGTQTIAEANVVSAARRPDAWENTQEIQIDIAPVRPRTLPVSRPRPPPPPPPLPVKKPALNSMSSTDRLKLDAIIAMAEQTVQAQAAAAAVEATASPQAGSSRSGSRPAEDEERRKRQKRTHMTEEELAEQKERRLRKLIGAVVVKSMNKYKDMMEHDTFKKYARECTDTLVKKEKKRNPSYQDVKHPSLSDDKKAKIKSFTKDYTHKILKHLKEKGKLRNPKSSSSLRTNSNDPRQAASSSTNGDTPSISTTPSQGAIQRLRDGELVDDIFGADEDMVMDLDEDTPEMQNDHPAPPSVPPATPPLPPVHVEVVDNVSTPTSQWET
The following text describes a protein:
Function:
Involved in the negative feedback regulation of pmk1 cell integrity signaling and is linked to cellular calcium signaling.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall.
Sequence:
MLFKSFALTLLFAAARVQAASNCSSGPYNISAQGTLDELNSCTVLNGDLYISDAGNSGITTLTVNGIESVQGDVVVSDGQYLTSLSFPSLKNVSGAFNVNNMIRMNNLATPELTSVGSLNLAVLPNLQELQFNAGLSDSDSVVIDDTQLQAIDGISLDSVTTFQVTNNRYIQEITMEGLESAQNIQISANSKGVSVNFSKLSNVTTATFDGISNVFIGNLKSAAGNLYFSNTTLDNISVPYLTEIGQSFAVLYSPELTSLNFPNLTTVGGGFVINDTGLTSIDGFPVISEIGGGLVLLGNFSSIDMPDLSDVKGALTVETKATNFTCPWSNDDSVIKGDDFTCQGSVATISATSSYDLSSTVSATSGSATSATGSATTTSYSSDSSASSSSSSSHESSAASNGFTAGALVLGSLLVAALAM
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MQEDEETQNVQQLPEIPENKELKKYWAQRYRLFSKFDKGIRLDYDSWFSVTPERIARHIADRCRCDLIVDAFCGAGGNSIQFAFKCERVIAIDIDPSKIELARHNASVYGVADRIEFIVGDFFQLAPSLKADVVFLSPPWGGPKYLSAPQFCLEDMQPNGFDIFKAAQKITSNLAYFLPRNTNVDQLIGLTTDGKAEIEQNILNNKIKTITAYYGELILDP
The following text describes a protein:
Function:
Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLRALLLLLGALAPAGLGLPTHAEPQPDGSQCVEHDCFALFRGPATFLAAGQTCERLGGHLMTVRSSVAADVISLLLSDDSPRLWIGLQLPTGCSHPGDLRPLRGFQWVTGDNRTSYSRWARQDGGGAPVCGPLCVTVSAASAAAPGEPAWEELPCGTEVDGFLCEFPFAASCRPLLVEAGAAPATAPHVSSTYSTPFGARGADFQALPVGSSAAVAPLGLELTCYAPPGAAEARWGREAPGAWDCSVGNGGCEFACNASAGAPRCLCPDGAAPQADGRSCAPAAPPSCHDLCEHFCVRTSDASGSYMCMCETGYRVAADGHHCEDVDDCALVPNPCPQLCVNTQGGFECHCYPGFDLVDGECVEPLDPCFGTNCEYQCLPLGQNYRCICAEGFAPVPDEPHRCQMFCNQTTCPADCDPNYPSTCLCPEGYILDEGSLCADIDECDNGYCQDECRNLPGSYECICGPDSPLAGQVSTECYPTQVSDGGDGGDDGGSGEPPGSGAPGSTPAPPPAAGPVHSGVAIGISIASLSLVVALLALLCHLRKKQGSGRAELEYKCASPAKEVVLQQVRTERTQPKP
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MSSSLTSLVPSDVKTLSEFGNFREHSNPNIAVDLQSKNLHTSSEFFFLQPVYSLSMVTLVTIFGLLGNITTGLVYLSPAKTFWHIVQRGSTEEFDSLPYVVKLLNGYMWVYYGLVKPNSILVATINGFGAVLELIYVIIFLILAPPRMRVITAILFGILDVVFPVAVVLISQLSFNREMQINISGFLSLLFSVATYGSPLSIMKTVVTTKSVEYMPFLLSFILFINGLTWTVYAVLTRDWFIGIPNGSGFVLGTAQLVLYAMYWKPKQPKRTSDNVEDDWQHEHLIADSGPSLKNNESRADA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MAASGAVSGVVAVEDGAVGKVVEQLVKKRELLRPEAPSGMPLRFDSAEQEANFHALMAALSACAMGYDALLQAHTGRGLRELVLFGVMGLYISGQQLTTSALAELTLENVSELFQLPLRDEAGATTVMPAVQSVPPHPLAPLAQRLLEVLHELADGCHRTTASERVQALKTTFPATFADSLELDREPLQHVDALPSGILNDDADAVALDAGAHLLIDLLWRRFHEHKDKALQKAFALDTRHQLFCTVDDDLVFHLIRLGVLSVPSKSADLDPRALRHGALAALLKLHQALADQEVKCCWRDMDQALRAVQLPHCNHSHSHGDEADGHGHGHSHGHGHSHS
The following text describes a protein:
Function:
Involved in spermatozoa motility. May also regulate cilium motility through its role in the assembly of the axonemal radial spokes.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MRASSGVYWIWHHSLLFISFFLKKSGSESKLSLQSEFLETFELPRSPGSQLEFLDLDVTTSGEPLISFPERQPSGELDQRPQDELEEEEGRDLEPERGDLEQEKRERRKEKSVSYISKKSEKESQPKARITKASLVSTATEDILFQRRESANMYPLTMTWSFGWNSSLPVYYLRENQRVLLYASGHTGVIYNVLKNNQYHLQGHPNVISCLCISEDRRWVATADKGPDCLIIIWDSFTGIPVHTIFDSCPRDNGIRAMAMTRDAKYLATISDAEIQKVCIWKWTLAVETPACTLDLPKEYGFQNYLIFNPTNNKELVSNSKTQVIYYTWYPEGGILVHSAPLLTEKTFNKLVGKFSQSVFHLNLTQILSATMEGKLVVWDIYRPLPSASSSMGFPHIKPCKLVHLQKEGITVLTTVDSYIVTGDIRGNIKFYDHTLSIVNWYSHFKLSSIRSLSFSKTPAAPPAENTNYPPDCTLKSDDFVVRNFIIGTSDASVYHLTVDGTKLEKLFVEPRDAICAISCHPYQPLIAIGSFCGMIKVWDYEQKKYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLESAISEPFRYSRSSVTHISFSHDSQYMATADVSFTVAVYVVRVKHRRRVWEYLARLRSHRKSIRSILFGVHLDSNEPRLLSLGRDRLLIEYNLLKSYKDHLAVLDIHRTDQGSYPTCMVWYPPLTKELFLLICNSGYKVKLFNSTTKMCRKTLLGPVYGSPIEQIQILPVKSTLELQKRYVVFINRDKVGLQILPVDGNPHKTSALICHPNGVAGMALSYDGCCAFTAGGQDRSVVQWEINLSALEAAVSLGGEDLTPFYGLVSGGREGKFYRELEDYFYYSQLRSQGIDTMETRKVSEHICLSELPFVMRAIGFYPSEGEIEDMFNEIRFSEYVDTGKLTDKINLPDFFKVYLNHRPPFGNTMSGIQQSFDILGFTNSKGEKAIQREDFLNLLHTKGEHMTEEEMTDCFATLFGLNPEGWKSEPAASSVKGSEICLEEELPDEITAEIFTTEILGLTISQDSGQDPRISEAEQSF
The following text describes a protein:
Function:
Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Sequence:
MIEKLTFGLFKKEDARSFMRLMAYVRPYKIRIVAALIAIFGVAATESYLAAFIAPLINHGFSAPAAPPELSAAAGIISTLQNWREQFTYMVWGTENKIWTVPLFLIILVVIRGICRFTSTYLMTWVSVMTISKIRKDMFAKMLTLSSRYHQETPSGTVLMNMLNLTEQSVSNASDIFTVLTRDTMIVTGLTIVLLYLNWQLSLIVVLMFPLLSLLSRYYRDRLKHVISDSQKSIGTMNNVIAETHQGHRVVKLFNGQAQAANRFDAVNRTIVRLSKKITQATAAHSPFSELIASIALAVVIFIALWQSQNGYTTIGEFMAFIVAMLQMYAPIKSLANISIPMQTMFLAADGVCAFLDTPPEQDKGTLAPQRVEGRISFRNVDVEYRSDGIKALDNFNLDIRQGERVALVGRSGSGKSTVVNLLPRFVEPSAGNICIDGIDIADIKLDCLRAQFALVSQDVFLFDDTLFENVRYSRPDAGEAEVLFALQTANLQSLIDSSPLGLHQPIGSNGSNLSGGQRQRVAIARAILKDAPILLLDEATSALDNESERLVQQALERLMENRTGIIVAHRLTTIEGADRIIVMDDGKIIEQGTHEQLMSQNGYYTMLRNISNKDAAVRTA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase. When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore (By similarity). The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex (By similarity).
Sequence:
MKNDNKLQKEALMRLSQLRFPFADAPSIVQAHQKDEQIQGLLIMKVTELCKLIKSQLFVNSYPKELSIFAKLLYLLFTTGRRGRTLGEEYVDLTYTNRKGTRLAGRLKMIVFAFAYPLCPYFITKLYKKIMKNNKESKIEDTESVAAFCKGLLDFILDVHMTLFYFKGAFYSISKRIFGMRYVFKHILSKNEANFREEGSQKYKVLGYILLAQNVMKWYPVLTSTLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMSDPSCAPCGHLFCWSCLMSWCKERPECPLCRQHCQPQEILVLRQ