lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in TCP pilus biogenesis.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MGYVRVIYQFPDNLWWNECTNQVYYAQDPMKPERLIGTPSIIQTKLLKILCEYHPAPCPNDQIIKALWPHGFISSESLTQAIKRTRDFLNDEHKTLIENVKLQGYRINIIQVIVSENVVDEADCSQKKSVKERIKIEWGKINVVPYLVFSALYVALLPVIWWSYGQWYQHELAGITHDLRDLARLPGITIQKLSEQKLTFAIDQHQCSVNYEQKTLECTKN
The following text describes a protein:
Function:
Invertase that cleaves sucrose into glucose and fructose.
Sequence:
MKSTLRLVEPLAASGCHGAASVSSAQRKVGDSWGYSPKRVAFHKQGRSYTCIKCEQNAGDSSRVVYNNQAHLEREALQEKVVVSSLQGATPEDSICVDTKSSSRREDVLVEELSQRPESVDSNTNDGAGSNGNGYKALDESPLEAEAWRLLKKAVVSYCGQPVGTIAANDPTDPYPLNYDQVFIRDFIPSAIAFLLKGEHEIVRNFIHHTLQLQSWEKTVDCYTPGQGLMPASFKVQTVFLDREGVKETEEILQPDFGEAAIGRVAPVDSGLWWIILLRAYGKCTGDLTLQERVDVQTGIKMILKVCLADGFDMFPSLLVTDGSMMIDRRMGTHGHPLEIQALFYHALRCAKEMLHPEAHDLIRSVNSRLAALSFHIQEYYWLDIRKLNEIYRYRTEEYSSDAVNKFNIYPDQISRWLLDWLPEQGGYFIGNLQPAHMDFRWFTLGNIWSICSALATKEQSEEILTLVEKKWEDLIGTMPLKICYPTLEEDEWRIITGADPKNTAWSYHNGGSWPVLLWQFTLACIKMGRSDLAEKAVAIAEKRLSKDWWPEYYDTKSGRFIGKQARLYQTWSIAGYLTSKLLLKNPDAVKWLTCEDDEDAASISCVDMNPRRNPDLKPQGDRHIV
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MIVKIYPSKISGIIKAPQSKSLAIRLIFLSLFTRVYLHNLVLSEDVIDAIKSVRALGVKVKNNSEFIPPEKLEIKERFIKLKGSATTLRMLIPILAAIGGEVTIDADESLRRRPLNRIVQALSNYGISFSSYSLPLTITGKLSSNEIKISGDESSQYISGLIYALHILNGGSIEILPPISSKSYILLTIDLFKRFGSDVKFYGSKIHVNPNNLVEFQGEVAGDYGLASFYALSALVSGGGITITNLWEPKEYFGDHSIVKIFSEMGASSEYKDGRWFVKAKDKYSPIKIDIDDAPDLAMTIAGLSAIAEGTSEIIGIERLRIKESDRIESIRKILGLYGVGSEVKYNSILIFGINKGMLNSPVTDCLNDHRVAMMSSALALVNGGVITSAECVGKSNPNYWQDLLSLNAKISIE
The following text describes a protein:
Function:
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Sequence:
MASGFIEITNKQGLSATLLPFGATLAKLTFPDKEGKNQDLVLGFNTIDEFESDTQSLGKTVGRVANRIKNSQLKFDGKEYKMTPNNGPHYLHGGPNGLGYKMGIGRHAPQSVSFSVKANEQEDGLPGDAKIDVTYTVNDRNQLIIEHHATCEIPGLLALTNHAYWNLDGSEDVKEHFLEMDSEEYVEVDDTFCPTGAIRCVKGTRFDFRNRKQLKAFGESENEILDLDNDLVIARKDPPITPTSNLRFWSQKSGIELSITTSYPVIHLYASKFLDCSGKNGEHYGANKALAIEPQFHSAAPNFENFPDVSLRPGQDYCQEIVYTFSHVN
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity).
Subcellular Localization:
Mitochondrion. Cytoplasm.
Sequence:
VRPLNCIVAVSQNMGIGKNGDLPWPPLRNEYKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLTEQPELKDKVDMVWIVGGSSVYKEAMNKPGHIRLFVTRIMKEFESDTFFPEIDLEKYKLLSECSGVPSDVQEEKGIKYKFEVYEKNN
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MKILSLRLKNLNSLKGEWKIDFTREPFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLSNVSQSQNDLMTRDTAECLAEVEFEVKGEAYRAFWSQNRARNQPDGNLQVPRVELARCADGKILADKVKDKLELTATLTGLDYGRFTRSMLLSQGQFAAFLNAKPKERAELLEELTGTEIYGQISAMVFEQHKSARTELEKLQAQASGVTLLTPEQVQSLTASLQVLTDEEKQLITAQQQEQQSLNWLTRQDELQQEASRRQQALQQALAEEEKAQPQLAALSLAQPARNLRPHWERIAEHSAALAHIRQQIEEVNTRLQSTMALRASIRHHAAKQSAELQQQQQSLNTWLQEHDRFRQWNNEPAGWRAQFSQQTSDREHLRQWQQQLTHAEQKLNALAAITLTLTADEVATALAQHAEQRPLRQHLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKTICEQEARIKTLEAQRAQLQAGQPCPLCGSTSHPAVEAYQALEPGVNQSRLLALENEVKKLGEEGATLRGQLDAITKQLQRDENEAQSLRQDEQALTQQWQAVTASLNITLQPLDDIQPWLDAQDEHERQLRLLSQRHELQGQIAAHNQQIIQYQQQIEQRQQLLLTTLTGYALTLPQEDEEESWLATRQQEAQSWQQRQNELTALQNRIQQLTPILETLPQSDELPHCEETVVLENWRQVHEQCLALHSQQQTLQQQDVLAAQSLQKAQAQFDTALQASVFDDQQAFLAALMDEQTLTQLEQLKQNLENQRRQAQTLVTQTAETLAQHQQHRPDDGLALTVTVEQIQQELAQTHQKLRENTTSQGEIRQQLKQDADNRQQQQTLMQQIAQMTQQVEDWGYLNSLIGSKEGDKFRKFAQGLTLDNLVHLANQQLTRLHGRYLLQRKASEALEVEVVDTWQADAVRDTRTLSGGESFLVSLALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNASGKTIGVISHVEAMKERIPVQIKVKKINGLGYSKLESTFAVK
The following text describes a protein:
Function:
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MTEQLVIHRHDYDAGNQGLSWARIIGIAFVIALHLTALMMLLIPAVAPKAPAEKERTTMVTLVDAPPPPPPPPPPPPPEDKPPPPVKNLSPPKPSPVPPPPEAPVVDVPEPRPSDIVTPPSPPAPPAPPSDIGASVDISSKNMNPPKYPPAAFRAGVQGEVILIVDVDANGNVTNVSVEKSSRNRDLDRAAMDAARKWKFNASTVNGQKAAGRVRVPVNFALN
The following text describes a protein:
Function:
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.
Subcellular Localization:
Nucleus speckle. Nucleus, nucleolus.
Sequence:
MSGDGDSSTTSSAGDGSTSKDKIPAFSEIRVIEVNRDNFAKIWPYLLVCIKSADFTAIDLELSGLGGKGLRSRDIAERYQAIRDAAHTRSILSVGIATMKLTHKSEKRRALRYETQVFNILTFSEKPFTIEPSALQFLAKHSFDFNRLIQSGVRFQGANCPLKTLFRELLGSSATFCLHNGFIDLAFIYKQLYDIDLPDTLDGFVNNLSDMFPDNYLPVADSKYLAEYQTRMTASFLEYVFRRTQGDNEIERQNNRYHIEICFPSSEKSIKALKNATESVDVRLPEGFPDHAIPIDLHIHVCKYFAYHGFCHARNTEKGCKLLHDVDTAIDLQRIKENKKAFKRKRRYNNVIAESVAEKTGTDEEAWKNAKFEQNLLTRDFRELKRNVVTGLHRAGVDAFMTAFAVIYQQRRTLMADNSVDLKFLNRVPLSAKDKPLHLRHRPVPVPQSEQIDAHLEAMVEINKQRDYIRMNAAATVIKSVQKEDTPCED
The following text describes a protein:
Function:
Has phosphatase activity toward PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
Sequence:
MSPVEPAGIMKKSHRQKSQRLWAKLVMRKWLNISGRDPEYGADTDNESENEDAREDNDDSSSDEEGGSGSRGRESKVYENAEDAIAAASAVVDAAAAAAEFISNDAPMKLRRRNSETLRAQYINNKEIRVCVGTWNVGGISPPSDLDIDDWIEINQPADIYVLGLQEIVPLNAGNILGAEDDRPVAKWEEVIREALNRVRPKLSGVKSYSDPPSPGRFKPFEETHDIIEEEVAFESDSDAGVEIHPIDEEEEEETDRLWALKHDGGVIGEVKTLVDPNTGLPVVEIKRQFSIPKKLDRQLCLRADSFKGISDDDSTQTGMKTINRMLSGKERIGLSWPEPPLNMLGPCVLDRQPSIKTVKSLKTAKSFKAYSSFKSVAGNNNGIPPEVLALAEMDLKLLMERKRRPAYVRLVSKQMVGILLTIWVKRSLRKHIQNVRVSTVGVGVMGYIGNKGAVSVSMSINQTFFCFINTHLTAGEREVDQIKRNADVHEIHKRTVFHSVSALGLPKLIYDHERIIWLGDLNYRLSSSYEKTRDLISKREWSKLLEYDQLVKEYRKGRAFDGWSEGTLHFPPTYKYQANSDEYTANDGKAPKRTPAWCDRVLSYGKGMRLVHYRRTEQKFSDHRPVTAIYMAEVEVFSARKLQRALTFTDAEIEDEGLVAVLV
The following text describes a protein:
Function:
Involved in an early step of the biosynthesis of the catechol siderophore vibriobactin. Vibriobactin is a chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm.
Sequence:
MKDMSLVNSKVLLVGSARGIGFSVLEHLLQAGAQVMAADCEWQLLLEQSESLLGRYPDQLTLKKLDLAEPEAVREQVNQWAEQVAGFDHLVCCAGILHVAPLHEMPMEQVSSIFTVNAFGVLACMQGVASSMKARQQGSMVIIGSNAANTPRMSIGAYGASKAALHMLVKCIGMELAPYGIRCNLVSPGSTRTAMQQQLWTEQYGEAQVIAGDAAQFRLGIPLNKIAEPADIAQAVLFLLSDNAGHITLHDLRVDGGATLDH
The following text describes a protein:
Function:
The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba3 lacks DNA-binding activity and plays the role of an adapter protein, bringing Elba1 and 2 together, thereby establishing a complex that recognizes the asymmetric sequence motif through the BEN domains of Elba1 and 2.
Subcellular Localization:
Nucleus.
Sequence:
MSNISNDSGLDDSANSGAVVSANGPLAATRLSWFLAEVDDGLMKDGKPNGRRRLCVLHSMELLESDVSDKYMTRFVEFRVNGMVLEAKLILAADERRLVDAALLSMSKEEREDAGGQQLLVQYTENEKAGERLIQKLVSPNNVMLLSTKPELKGNPLVRLAPGCIAHILYAYESRDYMEKILLHLKARSFDLAFDDNLEAEPEAMNDDTWMLVQYSPEPEMVVYQVVQYRQTVWRKENLFKDVIAYMQLPGSDIVLQAVVISYGQDKEVQDAKYEELQRFSFDIDFPLPEELEKHPDHMTSTALFSRTSLYQKAEQRDTTGEHRELRKSLEQMSEKAQGEAQMIIDAFDMVDNINKNLQSRLSGEVRSVVEVTSGDELH
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MTKPILGYWKIRGLAAGIRYQLAYSKVDFDEDVYEQGDGPDFSRASWMDVKNYQGLEYPNLPYIKDGDVALSESGAIHRYCAKKWAPDLLCLDDAEMYGKTEMAWGVVSDVKGFVTGPCYNGSMTKEELAAASLPRLELLAKSLNSNKFLAGDKVCCADFQFVELLEFVDFVSAGEVYRVYPQLKVYRDRLFGLSGLKEYYEKAEKLPFNNKVAKINN
The following text describes a protein:
Function:
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Subcellular Localization:
Nucleus.
Sequence:
MAETDPKTVQDLTAVVHTLLQQMQDKFQTTSDHIIGRIDDMSSRIDLEKNITDLMTQAGVEEIEGENKIPTTRNS
The following text describes a protein:
Function:
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
Subcellular Localization:
Cytoplasm.
Sequence:
MPFVELETNLPAERLPPGLPLKLCEATATILGKPAERVNVTVRSGMPMVLAGSAEPCAQLLVSSIGVVGSAQQNQGHSARFFDFLTTELGLGPERIFVAGCLWLCVEDGAAREDLHCAQENVVKVLPLIPAAYAGVQNSFHILTLTGSFGKGQTSHCALWLIFQLPALCRRAAVVVHK
The following text describes a protein:
Function:
Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis).
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Probably also has a lipid-anchor at the mature N-terminus. Has been suggested to have 2 transmembrane domains , but bioinformatic evidence does not support this.
Sequence:
MTAHTHDGTRTWRTGRQATTLLALLAGVFGGAASCAAPIQADMMGNAFLTALTNAGIAYDQPATTVALGRSVCPMVVAPGGTFESITSRMAEINGMSRDMASTFTIVAIGTYCPAVIAPLMPNRLQA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPPRLPLAQAARCCQASLTARPSVPASSPTSSLISLFAALSVQTRSASILASLSDNRGAYHKRIRKGRGPSSGYGKTAGRGTKGQKAHGHVKPWFQGGQTPLIVSHGRKGFVNQFAADMSELNLEKLQEWIEAGRIDPTKPITPKEIIKSGIIGSSIKDGIKLLGRGKESFKIPVTITVSRASASAIEAIEAAGGKIVTRFYTKESLKRLVEGKSLHTDKPLPVGKEHVEEILAQARSLKKKYYRLPDPTSRWDIEYYRDPAHRGYLSHQLAPGESPSLYFKVPTGGEKVKVVRADKVKASKTGDVASEKLF
The following text describes a protein:
Function:
Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI), probably due to the loss of a physical impediment to cell-cell contact.
Sequence:
MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLILTMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWAQALNAEQV
The following text describes a protein:
Function:
Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.
Sequence:
MQFFRPILIVVVAIVVQATDAFTVGSATGLAAGTTGGGSATPVYPTTTAQLVAYLKDAVPRVIVLNKTFDFRGTEGTTTEAGCRPDYTRECIAKNNGYKSQDVILQSGGMSNTGGCSNGTSVTVTYDNAAITPLMLNGSKTIRGIGTSGVIMGKGLWLNGDNIIVQNIHITELNRHLVWGGDAFYMQGNNGGSTAMNKIWLDHIKVSHVGRQFLTTNAASVSTMTISNSDFDGRTDYSATCDGRHYWSFIFYGKNTRFSMLNNYVHSTSGRSPKIGGDSSANVVAHIANNYWADNSGHSFEIGVNAWVLAEGNYFQDTTLPLMTGSDGTLYAATATAECNSYLGRSCAANVVDNSGAFQSRNGATALSTAKSYSAISSYSPSAAKKYSETTNNFGIGVLN
The following text describes a protein:
Function:
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
Subcellular Localization:
Nucleus speckle. Nucleus. Cytoplasm.
Sequence:
MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEGSRARMREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVEYETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRR
The following text describes a protein:
Function:
Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).
Miscellaneous:
MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEKETNYVENLLTQLENELNEDNLPEDINTLLRKCSLNLVTVVSLPDMDVKPLLATIKRFLTSNVSYDSLNYDYLLDVVDKLVPMADFDDVLEVYSAEDLVKALRSEIDPLKVAACRVIENSQPKGLFATSNIIDILLDILFDEKVENDKLITAIEKALERLSTDELIRRRLFDNNLPYLVSVKGRMETVSFVRLIDFLTIEFQFISGPEFKDIIFCFTKEEILKSVEDILVFIELVNYYTKFLLEIRNQDKYWALRHVKKILPVFAQLFEDTENYPDVRAFSTNCLLQLFAEVSRIEEDEYSLFKTMDKDSLKIGSEAKLITEWLELINPQYLVKYHKDVVENYFHVSGYSIGMLRNLSADEECFNAIRNKFSAEIVLRLPYLEQMQVVETLTRYEYTSKFLLNEMPKVMGSLIGDGSAGAIIDLETVHYRNSALRNLLDKGEEKLSVWYEPLLREYSKAVNGKNYSTGSETKIADCR
The following text describes a protein:
Function:
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Domain:
The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
Sequence:
MFQRLNKMFVGEVSSSSNQEPEFNEKEDDEWILVDFIDTCTGFSAEEEEEEEDISEESPTEHPSVFSCLPASLECLADTSDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEATRGTDELHSPSSPRVEAQNEMGQHIHCYVAALAAHTTFLEQPKSFRPSQWIKEHSERQPLNRNSLRRQNLTRDCHPRQVKHNGWVVHQPCPRQYNY
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSDKRADGRLEGTSDTFGGLVIKKKKVEGDSKPTEPSGKSLLGLDRLASTKREHARKRLEDDDDRGVTESVRKGIEKVHEKHRDRDDRGMKYKSRDDDRRRDRDRSERREPSSRRGWKDRSGDQTPRFKVPDTPSRMSWDQDDREGSSRKRNSWDMPTPRGERDRKRYMDSERSISSAWRSERRNRDDEKRRRHRKPEDSVRSVKEEKAEPTFHDDEERAQWEEEQKNLDREWYDNEGAFDDEYNPFNKVSDEFVEKREKQWQEKTQKPRLTVKQQAIKRENELWENNRLHRSGVVAMADELSSIFEDETDENRVTILVQNIVPPFLDGRIVFTKQAQPIIPVVDTTCDMAVSAARGSVAVRKRREVEDRKKAQDKHWELAGSKLGNLMGVKEKKDETADPEDDDSGNYKESHQFASHMKDNEAVSDFAMEKSIKQQREYLPVFACRQKMMNVIRENNVVIIVGETGSGKTTQLAQYLLEDGFGDSGLIGCTQPRRVAAMSVARRVADEMGVDLGQDVGYAIRFEDCTSEKTIIKYMTDGILLRECLGDGSLDQYSAIIMDEAHERSLNTDVLFGLLREVIAKRADLKLIVTSATMDADKFADFFGGNCPTFTIPGRTFPVELFHARTPVEDYVDAAVKQAVTIHLGGMDGDILIFMPGQEDIECTCEMIKEKLGELDEAPPLAVLPIYSQLPSDLQAKIFQRAPGGMRKAIVATNIAETSLTVDGILFVIDPGFCKMKVYNPRIGMDALSIFPVSQASANQRTGRAGRTGPGQCYRLYTERQFKDELLKSTVPEIQRTNLANVVLLLKSLGVDDLLKFHFMDAPPQDNMLNSMYQLWTLGALDNTGQLTPMGRKMVEFPLDPTLSKMLIMSAEMGCSDEVLTIVSMLSVPAIFFRPKGREEEADAKKEKFQVPESDHLTFLNVYIQWRTHKYSAKWCADNYLHVKALKKVREVRAQLKEIMQDLKLPLISNGSEWDIVRKCICSAYFHNAARLKGIGEYVNVRTGIPCFLHPTSALFGMGFMPDYVVYHELIMTAKEYMQCVTAVDAIWLAELGPMFYSIKESKQSRKELKMESVRTVETMEAEMREAQKEMERRKEESDKAFKRPESSRRVVEVGSKSARSERRKLWGL
The following text describes a protein:
Function:
Involved in morphogenesis and proliferation of mitochondria. Does not act redundantly with PMD1. Is not involved in peroxisomal proliferation.
Miscellaneous:
MISCELLANEOUS: Plant cells silencing PMD2 show enlarged mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MAEERSLNGEATGQDDESFFDSDQQGDDGKSTELNQKIGDLESQNQELARDNDAINRKIESLTAEIEELRGAESKAKRKMGEMEREIDKSDEERKVLEAIASRASELETEVARLQHELITARTEGEEATAEAEKLRSEISQKGGGIEELEKEVAGLRTVKEENEKRMKELESKLGALEVKELDEKNKKFRAEEEMREKIDNKEKEVHDLKEKIKSLESDVAKGKTELQKWITEKMVVEDSLKDSEKKVVALESEIVELQKQLDDAEKMINGLKNVVEEPLNGIEFKSWSPNVTAVGSGGAVAAVAVAVAGAAVVCYIYHSRRV
The following text describes a protein:
Function:
Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
Sequence:
MNISIEIKERDTDHIDIFVAGEIDAYTAPKVKEALEVYQVKEGIVLRIDLTEVSYMDSTGLGVFVGAFKSLRQRQSELVLFGLSDRLFRLFEITGLSDIIEIKNVEGEMNGNNA
The following text describes a protein:
Function:
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein.
Domain:
The C1q domain is essential for the function in Wnt signaling.
Sequence:
MRKTETMVQLSPSRTLETLTPSELTVEKDDGQGSPKPESPRMLSALQLALSSTTVYCGYEKYIEDGLICLKHKIRNIEKKKLKLERYSDKLKKGEKLNEDQLEAVGKYDEVVHNLKFAKELQKTIGSLTQDLLKAQRKAVRQEKQMKTDEEKSRLSLMLQVQYVLHSLQREDVRKNFCNTRQYSCYMSTQDMEGLMDLASLVGCKRDYSISLEDQMRRAAIVYWELLEGNEKPVAGSTYKHMKEKLLRLVDSGFFDNIPLPKSDSQEKTETIKPDSQSRPSGLTTLVKLSSNEVPSKEFLNRRYMPETDERRRGETASPRNWKEDFLAMKEREPPDSWEMEELADPPASSQSPIQKPWKGAAGLIPKTVDIVKRSTTDPKEKRQRKKAEQDSKSMPVAVEVFSSPSPLPKDPVQRRQQLETLMDQISGSFSFMQESLLDGESSPVNTQTKRCRPSPGSSTPIVQRELTKSPSDILPSSQRSTPLRILLSGEGKGCLSNGDRSINGSDLELHSEDKPRKQAEGFNSPPLYRRGSSISVSLENQSTVQAGRQMLCNGVSSSGSAQTFSTPPSRRSISAENPFHNIHSVFNVIGESSGMKADESGFSESIHRSFTSAKTSSVTTASTQTPPELNPPEEDLQIEGQYPLECAVSAGGPVFSSSHSRVGQSCYSRGAVRGGYDAYRVNVRSPGGSFMSQTHREPASALYMARENGYQQNFKRGAGTATQRSSAGWSDSSQVSSPDRDGAYPLDSGLSDTLSIPAMEVPMNPQGPHTLMPVHVYPLTQLRVAFSAARTANFAPGTLDQPIAFDLLHTNLGDMFDTGSGRFTCPATGAYVFIFHILKLAISVPLYINLMRNEEVMVSAYANDGAPDHETASNHAVLQLFQGDQVWLRLHRGAIYGSSWKYSTFSGFLLYQD
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
Sequence:
MSRRRAAVKRDVLPDSRYSDKVVTKVINSIMLDGKKSIAEGIFYSAMDLIKEKTGQEGYDIFKQALENIKPQIEVRSRRIGGATYQVPVEVKADRQQTLAIRWLTTYTRARKEYGMIEKLAAELIAAANNEGATIKKKEDTYKMAEANRAFAHYRV
The following text describes a protein:
Function:
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Cytoplasm. Nucleus.
Sequence:
MAAPAGGGGSAVSVLAPNGRRHTVKVTPSTVLLQVLEDTCRRQDFNPCEYDLKFQRSVLDLSLQWRFANLPNNAKLEMVPASRSREGPENMVRIALQLDDGSRLQDSFCSGQTLWELLSHFPQIRECLQHPGGATPVCVYTRDEVTGEAALRGTTLQSLGLTGGSATIRFVMKCYDPVGKTPGSLGSSASAGQAAASAPLPLESGELSRGDLSRPEDADTSGPCCEHTQEKQSTRAPAAAPFVPFSGGGQRLGGPPGPTRPLTSSSAKLPKSLSSPGGPSKPKKSKSGQDPQQEQEQERERDPQQEQERERPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPAAEEGALVPPEPIPGTAQPVKRSLGKVPKWLKLPASKR
The following text describes a protein:
Function:
Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MALVDYTSSDEDDVDDDFDQKHQHNEEDEKNITTKTSNSNNLKRKRSISCSSELPPLPSKFHDLYASTVRNSTSDDPSLHGGRKRVIPHIEGNWPTHIYIEWYPSTIEFRLLSSLISKVVSLKRFEIQTFLTSDLGVPLPLHVSLSRAIGFSKDVKDSFLNSFEQAIKSSGIRPFEIGFSGLAWVPNYEKTRWFLVLRLNIPKSNALNKLLHVSNKVVEEFGQPPLYADSRASEYGTKIAHPSRDVKNFKAKTQQKENFVDMVDLSKAFHISIAWTLLPPGQELIEATERLTANELIRVQEIQIQTKEIKAKIGNVTYAMSLAFATTRRSSKASEDEPTVCVSTTLKISSPRAERVLPAEKPHGFSTGPTIG
The following text describes a protein:
Function:
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSTFSGDETAPFFGFLGAAAALVFSCMGAAYGTAKSGVGVASMGVMRPELVMKSIVPVVMAGVLGIYGLIIAVIISTGINPKAKSYYLFDGYAHLSSGLACGLAGLSAGMAIGIVGDAGVRANAQQPKLFVGMILILIFAEALALYGLIVGIILSSRAGQSRAD
The following text describes a protein:
Function:
Catalyzes the condensation of the acetyl group of acetyl-CoA with oxaloacetate to form citrate. This enzyme is highly Re-face stereospecific with respect to the C-2 of oxaloacetate.
Sequence:
MKKCSYDYKLNNVNDPNFYKDIFPYEEVPKIVFNNIQLPMDLPDNIYITDTTFRDGQQSMPPYTSREIVRIFDYLHELDNNSGIIKQTEFFLYTKKDRKAAEVCMERGYEFPEVTSWIRADKEDLKLVKDMGIKETGMLMSCSDYHIFKKLKMTRKETMDMYLDLAREALNNGIRPRCHLEDITRADFYGFVVPFVNELMKMSKEANIPIKIRACDTLGLGVPYNGVEIPRSVQGIIHGLRNICEVPSESIEWHGHNDFYGVVTNSSTAWLYGASSINTSFLGIGERTGNCPLEAMIFEYAQIKGNTKNMKLHVITELAQYFEKEIKYSVPVRTPFVGTDFNVTRAGIHADGILKDEEIYNIFDTDKILGRPVVVAVSQYSGRAGIAAWVNTYYRLKDEDKVNKNDSRIDQIKMWVDEQYRAGRTSVIGNNELELLVSKVMPEVIEKTEERAS
The following text describes a protein:
Function:
Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MESTPKKAPRSKFPALLVVALALVALVFVIWRVDSAPSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRARTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRVISLKTSVGQFASAMRPIFTLIDTRHWYVIANFRETDLKNIRSGTPATIRLMSDSGKTFEGKVDSIGYGVLPDDGGLVLGGLPKVSRSINWVRVAQRFPVKIMVDKPDPEMFRIGASAVANLEPQ
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTQIDEISNLTPIQEFYSGTNIFITGGTGFLGTILIEKLLRSCNDISTIYILARNKKGKNLQSRIDELFDDSIFDRLKKEFPKFRHKVVGIGGDCSLPDLGISQQDRQVLINEVSVIFHVAATVRFDEKLKMAVAINVRAPQDMLKLAHEMPHLKSMVHVSTAYSNVPNKVIEERLYPVPVDSKKLILMAETLGDNVLDNITPMVLDKWPNTYTYTKAVAEDIVRQDGLDLPIGIYRPSIVVSTYQEPTEAWINNLYGPTGVCAGAGSGILRALHANSEVNANIVPVDMCVNSLIATAWDVGVKFENSKKSCNKYEIPVYHFESSNDQPLNWGRFMRLSYSHGKKTPSVKAIWYYTFNLYKNYYAYLIATIFLHYLPALFVDGALLCMGKSPKMLRIYKKIHKFTSVISYFSTRTWIFQSSNVQKMIERMSEADQKIFFCDLKKLDWNKFFATYLRGIRIYLLQDPIETLEEAHIRWNRLYWLHQGVKALVAFLLIRVLWWILSTVFIY