lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSASSVMSIIDGHELTRRYCETLEYDLASRYWTHSLSPVAFDTPTNLLIVLIVLIHAITCCLLFLSFYKSLPPITKAYGSICVVANVAFHLGPYRLEHIAFLHKLVISDFQVWRLLTNFFFLGNFSVNFGIRLLMIARYGVQLEKGPFERWTADFLWMMIVGALSLLALSAIPMLRSPFLGISLVFMLLYIWSREFPNAQVNVYGLVALKAHISYKSVSRLCLNSAIFFHLLLLVVWVCWCKCLYVTAGTQAFYLPWAMLALDVLFGSPLKPDLMGIIAGHIYYFLTVLQPLAGGRNILATPTCVYPFMHKLVEGGRLGDPTNAHVQQDRATGVAFRGRS
The following text describes a protein:
Function:
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Subcellular Localization:
Nucleus.
Sequence:
MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITS
The following text describes a protein:
Function:
Uniporter that mediates the transport of neutral amino acids like L-tryptophan, proline and alanine. The transport activity is sodium ions-independent, electroneutral and therefore functions via facilitated diffusion.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MEAPAPAETAGCEELDMDVMRPLINEQNFDGSSDEEQEQTLVPIQKHYQLDGQHGISFLQTLVHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKSTLGYSDTVSFAMEASPWSCLQRQAAWGRQVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLGSTPIVSNGSDLSHACERRSVDLRVYMLCFLPLIILLVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRESKRFPQALNIGMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGVTARLHAKWKRICEFGIRSLLVSITRAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKDHYNIWMILKNISIAFTGVVGFLLGTYVTVEEIIYPTTAVVAGTSQSPFLNVNSTCITSGL
The following text describes a protein:
Function:
L-rhamnose binding lectin. Has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. Hemagglutinating activity is inhibited by smooth-type lipopolysaccharide (LPS) from S.flexneri 1A and E.coli K12, but not by rough-type LPS from S.flexneri, E.coli K12 and E.coli EH100. Agglutinates E.coli K12 and B.subtilis.
Sequence:
TRVVTCDNGENVQFLICDSGVIFIERALYGRTDGTTCKEGRPANQLTNTQCSQTGTLEVLSHRCNGKQVCEVNTEVFRTSDPCVGIYKYLETTYTCLPATRSITCEGSDAPLECDEGTIQIHSANYGRRDQLVCSFNRPANQLANTNCLSQSITTSKSAERCNRKSQCDVPASNSLYGDPCVGTYKYLDVAYTCG
The following text describes a protein:
Function:
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle. During prometaphase and metaphase, phosphorylates the kinetochore component dam1 of unaligned or unattached chromosomes to promote mitotic sister chromatid biorientation. During meiosis I and together with moa1, required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MASVAIKEPKTAITPKKKSKASRLCFTPPTNLHNNKKNIFYTRYDCIGEGGFARCFRVKDNYGNIYAAKVIAKRSLQNDKTKLKLFGEIKVHQSMSHPNIVGFIDCFEDSTNIYLILELCEHKSLMELLRKRKQLTEPEVRYLMMQILGALKYMHKKRVIHRDLKLGNIMLDESNNVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSAGVVMYALLIGKPPFQDKEVKTIYRKIKANSYSFPSNVDISAEAKDLISSLLTHDPSIRPSIDDIVDHEFFHTGYMASTLPDEILHSMPIWPSSQSKSSFQRNLDFVASASGVGFGNSAGVEKNKPYALRTDEVDNDRILPSVLSPRDRVNPVMKIGPETKPVPSKLSTALHAARKSTDGSLGSRVKVLREESQSFVPTKSAVTEQVEPIQLIRSLSANTVSRLSKVGNMKSDIWISVKKTALKIGMALEAHTHALTSEDADSEPVLFITKWVDYSNKYGLGYQLSDESVGVHFNDDTSLLFSADEEVVEYALHPKDTEIKPYIYPASKVPESIRSKLQLLKHFKSYMGQNLSKAVQDESFEKPKNSTSNTMLFMQHYLRTRQAIMFRLSNGIFQFNFLDHRKVVISSTARKIIVLDKERERVELPLQEASAFSEDLRSRLKYIRETLESWASKMEVS
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Apical cell membrane. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGTRTAPPSYLPRGSAPPTPLTLLLLPCCVSVPAALLWSTLCCEPAKYDPSFKGPIKKRSCTDIICCVLFMVFLLGYMVVGILAWLYGDPRQVIYPRNSTGMYCGIGENQGKPNVLYYDLLKCVTGTNILAAAMNGLQCPTTQVCVEKCPTEFMWAISNDSPAKVYNQEYCQPSINLTITNLTVAEIAAKELCPVFLVPSTSFFNRCFPGSNLTFPADFSINGLTGNQSKANISEAASQILDSFNFQNVGKKIFEDFAKSWPWIITALVIAMVVSLLFLILLRFTAGILVWVLIVGVIGVIGYGIYHCYMEYDTLNKQGVSVSDVGFTFNLGVYFRVKETWLAILIVLAVIEAILLLVLLFLRKRILIAIALIKEASKAIGHIMSSLFYPLVTFVLLVVCVAYWGMTALYLATSGAPIYRISTVNTSLPGCENITGNETCNPMTFSPSSSCKEARCIFQRYNNEGLFQTNLFNLQIYNVIGFLWCINFVIALGQCVLAGAFASYYWAFHKPKDIPFFPVAESFMRTLRYHTGSLAFGSLILTIVQLIRIILEYLDHKLKGAQNPCTRFLLCCLKCCFWCLEKFIKFLNRNAYIMIAVYGKNFCVSAKNAFKLLMRNIVRVVVLDKVTDLLIFFGKLIVVGGVGVLAFFFFSGRIPIPNDSFKSPALNYYWIPILTVVLGSYMIAHGFFSVYNMCVDTLFLCFLEDLERNDGSPEKPFYMSKSLMSILNKKNRPPKSEEKTKKK
The following text describes a protein:
Function:
Activates erythroid-specific, globin gene expression.
Sequence:
MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPTLLRDELLLLGGPASSAYALNPFSASGGWGRAGQLHPKGRELDPAAPPEGQLLREVRALGVPFIPRTRVDAWLVHSVAAGSADEAHGLLGAAAAASSAGGAGASVDGGSQAVQGAGRDPRAARSGPLDAEEEEKAPVEPTAQVPDAGGCASEENEVLREKHEAVDHSSQREENEERVSAQKENSLQQNNEDENKVAEKPDWEAEKTTESRNERHLNGTDTSFSLEDLFQLLSSQPENSLEGILLGDTPLPGSISDGMNSSAHYHVNFSQAISQDVNLHEAILLCPNNTFRRNPTRTSQSQEPFLQLNSHTTNPEQTLPGTNSTGFLSPVNNHMRNLTSQDLLYDLDVNIFDEINLMSLATEDDFDPIDVSQLFDEPDSDSGLSLDSSHNSTSVTKSNSSHCVCEGATGYCTDHESSSHHDLEGAVGGDYPEPSKLCHMDHSDSGFHGDLTFQHIFHNHTYHLQPSAPESTSEPFSWPGRSQKIRSRYLEDTDRNLSRDERRAKALHIPFSVDEIVGMPVDSFNSMLSRYYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLENDVCNLQAKKETLKRERTQCNKAINIMKQKLHDLYHDVFSRLRDDEGRPVNPNHYALQCTHDGSVLLVPKELGASGHKKETQKGKRK
The following text describes a protein:
Function:
Hydrolysis of sulfocarbamoyl esters of paralytic shellfish toxins. Does not hydrolyze the carbamoyl esters of paralytic shellfish toxins. Ester hydrolysis is significantly affected by the stereochemistry of sulfate esters at C-11 of the substrate toxin.
Sequence:
TTEEVPLNPEPRTECDSDNCAAGERPYAPNIAIENGDTIIAIGVVADVMFVIDXNCPLYCNFCIVADVMFVIDLVYEVGSFEALQQAIDNIMFT
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHGRARVSVQHQHSDAGAKEAAKDKRRAAQYAEQLAEVLRSNQEKDYGKEAVEKSAALLKTNPDMYTAWNYRKLAIKMLLAEADDAAKARIFEQELVLIFEALQVNPKAYGAWYHRKWILQLMGVHAPLQREFKLLDKLLKQDERNFHGWAYRRFLVRQADAPDTQEMAFVQQKIDETFSNFSAWHYRSKLLTKMHLSKEAIAVGPEQASAWLEPEFELVDNALFTDPNDTSAWIYQAWLLQNTVPNPGSVLTGMWPPSGVTVPLAKPPTPSSSSPTLPAILSFSKPVSGVNRHTVPATIRTPEASKKTGKDWTPVGSQGEASKVWVQELPAGRIESAELHVHVGAGPGIRTAEGVQVVRSASSGFSVRMVDESDADAVRLQDGDVSRGAGESDAGEPASDVSQLALPGYAASSVPKGPENGDWKGWREELFARQLDLREQQEELEQGKSKWILLGKARLLAAMRLLPTDAAVSSRLHEEQQIYRDLFALDPAHAEYYGEMLGQLRLEEITADRRQLESHMVRTSRGGLPCLQLRLRDLGLRRLGALDALLWVQHLDLSRNALRSVEGLEALQLLRSLDLSHNRISHASGLAALHLLPHLRWLSLASNQLGASPVDTQFYSSGIRREVVDSGLDTGPRELQRVFGGLMGLSLDLLELGGNEITQVEGCEAFIRRILPRTSIKL
The following text describes a protein:
Function:
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein.
Sequence:
MAAAAATAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQQQHRAGGRGNKTRNSNNNNTAAAASVAAAPAGMGVRPGSGDFAYLRTPAGLGRLSASAPESPAGGSGVAAAVPAAGSKVLLGFSSDESDVEASPREQAGGGGARRDRAALQYRGLKAPPAPPVAGEATSGNSAERRKPHSWWGARRPVGPEPQLPSGSDGAAEDVDEEVADGEDRDPEAEEPLWGSRAVNGSRLLPYSCREHYSDSEEEDDGGDVASARQVLKDDSLSRHRPRRSHSKPFSALTAKSGGSRQETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAEPGGGGGGGGCDQVDSIPRYRAGAKKLAPLLSPPSPDVDSTLESPTGPLKTNNHIGGGGAFGVDSPSLYANSIPPGAAATAPGSLRINHANHTGSNHTYLKNAYSKPKLCEPEEELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVPEDGRLLKNPFDETFGKIQASEKNLMMSTLYKLHDRLAQIAGDHECGRSSQRMLSVQEAAAYLKDLGPEYEDVFNTSLLWIFKNGKDVGIRCVGYGPEEDLTNITDVQFLQSTRPQMPFWCRFRRAFITVTHRLLLLCLGVVLVCAVLRYMRYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQETKDLQPYMPIPHVRDSLIQPQDRKKMKKVWERAVDFLAANESRVRTETRRVGGADFVVWRWVQPSASCDKTSVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDHWHLAIQEAILEKCSDNDGIVHIAVDRNSREGCVYVKCLSPGHAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTCSTPLKPSDKHMNSMSHLRLRTGLANSQGSS
The following text describes a protein:
Function:
Embryonic transcription factor regulating downstream genes involved specifically in the sex determination and dosage compensation pathways, or regulating other genes involved in the coordinate control of both processes. Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Involved in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Similarly, might contribute to X-linked gene repression through recruitment of the dosage compensation complex to the X chromosomes in hermaphrodites. Seems to be involved in the depletion of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes. Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2 pathway.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to X chromosomes in hermaphrodite (XX) animals.
Sequence:
MSDEEDIDESFEIEEDGISITDARGNSLKAQQIAGKERNLDPEADDLEVVVNFYEAGDGTFQLQLPKLTAVKPVDKVNDVLDFINFDKKVCDGIHSSIKLVSQRDQTGPAPFPKHKLTCAHCDWSFDNVMKLVRHRGVHKNVGVYMCQVCLTLFGHTYNLFMHWRTSCSQTSTTATDIEIQKAETPYLHRNVLNVLGSLNRASQYYCTGGYVFLPSDWCITNKEIVMEKDHMSSCHLCHLPVPNKFLEAHGNVHRGRFRIDGRIYGDYFCHICGTVFIEQDNLFKHWRLHCEEVIAYTPVDQYLSNTELATLAWLVLQTTISQADIECLRVSSSLITEKLAKEHAERHGIANSMHKYYHFPQEIWPLKTFVNLDLVNDAIPISGENSFKIKDPKRPVHIMNLLATACPGFYATGKTFNMICSTKKSESDTKKVYRVILRYTTEGSVIQSYDFTARSFPKLRVDSETPEGVFSHPLADFNVESNEAIVCHKCDSKKLTITFSTEVRLKYHLLRHSESRKDGYHCAICKIIVYNRSHEEHWINDCIPLQKLYRDQKDRECFDAEFAAKCASIIKKLRIRTLIRWKERANEDWVETKQTPDRIGEDFAIKFQVGTTALKTLMAGLEEHYKNAQARHEAYKYSEENFLPPLSTPVVVCFHCGTRCHYTLLHDHLDYCHYWPRNKRLVNEEFHKWKKNGCRNTWRVMKSVAEAMQIEVPFISEEQYSKILDYHTYFCNDTRYKVQDSINNWNDCSTIRDVDLSEKLSVAEIVQKGEDSVMAPEPDIIKNVYFPSARIITDNMLLRMTEINLNDVVQRDPITKEELTGKFKEVQDEQDAILFGDYRAVLRSKGIMVNSISDFVAPPDELAKAKASQESAGQESVDHRNRREREFIQQYMGKDLALEAAARENGRLVEVDEEAEDYELTPKELNARRLVERNRHREMCKTRCEHGEYDYEKFKARQVPINPAKMKERKYLTRVVHESGPDDDVCPDEPENNIIAFSPKYENSLSDFRISAIGFREKYLADDKKKRNGIPIRKMTEAQKGVALDYDTLMARHGGRPDVIMNPAGTVFVGGFVFDRKPTCQDNMQTVYVLRNGYAHRYRIYHCEDTNGIYKFVWPQEQSFDPDSLAKSARVRMVKQVKSPEHMIHHIEEIDESIGHNYRLNRKRRNSETREHELIELDTDDLNEPSTSDGRYSFGHHGYR
The following text describes a protein:
Function:
Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MVTNNGDGEHLGIRRNGNLRHPSNNMKIPRRAQSTVLNSNPFYSRKYSMSTLTPRDICRSVDSRVFVDMSSPNFQTLEDPHRDEIINSVRLNYLNSSKRSSVSHGNEAIPRVNPTKNSSASTIAAANVDSDDDETNLSSAGGDITHDIYKLVKAEDPKRLRRPRSMENVTPKIEHHTKLSSASGLNVPGGFRREFIVNKKRQEHQLNDSASSDFTSHESDSINQSSPSSNQDIDKVPFLTRNFLEFLYVFGHFAGESFEDDFIPDSSNMMIRGEDERSALLSRPDHMKVLPSAKGTTSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFFSVSMLAFFGIYSYWCYYILVQAKSSCGVSSFGDIGLKLYGPWMRIIILFSLVITQVGFSGAYMIFTAKNLQAFLDNVFHVGVLPLSYLMVFQTIIFIPLSFIRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLFFDLMGTPAMGVVYGLNADRWTLFIGTAIFAFEGIGLIIPVQDSMRNPEKFPLVLALVILTATILFISIATLGYLAYGSNVQTVILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKIIENKFFPKFTKIYVKHDDLTTRVELRPNSGKLNWKIKWLKNFIRSIIVIIVVSIAYFGSDNLDKFVSVIGSLACIPLVYIYPSMLHLRGNSLPETKGEFWRFKPMLDTILIFFGIASMLYTSYQSIFGV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Recognizes miRNA-empty Ago1 and triggers its degradation via polyubiquitination independently of the Bag6 complex. By targeting miRNA-empty Ago1, eliminates dysfunctional Ago1 not able to bind miRNA and thereby plays a role in the quality control of miRNA-mediated silencing.
Miscellaneous:
MISCELLANEOUS: 'Iruka' means dolphin in Japanese. The name was chosen because dolphin preys on the Argonauta octopus, similar to Iruka 'preying' on the protein Argonaute.
Sequence:
MAEAMVVEDRPAEAKRFFCHMCNVEINIPNSDFTCPLCANGFVEELPANAPEMDSSTAGASGSARSGSSGSGSSGSHDTLSRGSSSSGSQVNVESLRNDIVSLLNMRNVPNLEITIEPNRRHSNVLHLGGFGGPSGSDSARGLTAGGRVRPANLDRLDNVLFDFLQSLPLAGATAEIVTGPGGGGVGGGGNSHMFFMGNPGDYAWGREGLDTIVTQMLNQMETSGPPPLSAQRINEIPNVQINAEEVNRKIQCSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHSTCPICRKSLADDGNDADDEFVMLDAFGPEMAADGSNSERRSASTATGTDNPSPANNPSQAAAEGGRTRPDANPAQAARNNIFTFDDDNMFLD
The following text describes a protein:
Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
Subcellular Localization:
Secreted.
Sequence:
MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPHSRNICDISCDKFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWLCEKL
The following text describes a protein:
Function:
Participates in transcription termination.
Subcellular Localization:
Cytoplasm.
Sequence:
MITRRKVTIAPEQLRYIKLFQDMLGVSPRDVVEDKEENRLIFVVEKGDLGRAVGRGGRKLKAMKRFLKGDLDYDIEVVEFDDSPEGFIANLLSPARVQKVKIVHQDDGITAIAYVLDEDKSLAIGRNGRRIKRTRLLAKRWYDIDNVKIATWVPHDSR
The following text describes a protein:
Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER).
Sequence:
MASPLPVRTLPLILILLAVLAPGASDFNISSLSGPLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVVKSSFMVPPCRGRRELVSVVDSGSGFTVTRLSAYQVTNLVPGTKYYISYLVTKGASTESSREIPMSTLPRKNMEGIGLGMARTGGMVVITVLLSVAMFLLVVGFITALALGARK
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGVGGESVHLRRSSTTATTTGSSKSSLNISKSVSPTGNKAVSPMSSPNSLQSGATPTIAQLQSLLKQQQQPNHSITTNNNNNKSVSVEIDDLKSQLQHSNINDTFNEDEEIEEVTDEVIINHDYHSSEDEYEDDEDEDENNNSVNNNSNNNSNNNNNNNTSISSAHSCESIAEEEELTASPILSRQYSYTIGHGTKPDVVLSIGGGFHSSPRSNRSESTIVHEDDLTNQNDKVINAKDKISSDYKRMMEDPEAFRNEKLKQRKSKFFTKKDLEEIPFNPSSGTQLRSTLFQQFMNEKIQMISENPEKYKSELMKFYKQNLKPQVPKSPQSSGSLSTHSDKLKTSSSLQRSRSVSQPPVVTGNSKNAIGSLDTILEKERKRDGNQDRQLPILFTKCVDFLSNDEALKTEGLFRVAGNSSEVEDLMKSILLYGSDIPSNCCYHVVSNMLKKFLRQLSTPVFTFKYHNDFIQTMKLNNDEERIKAIKEILKLIPPVNQLLIKELMKFLVKVTSFSNVNMMHAHNLGLMFGPNMLKAPSDSEMNAISMLDAGNQVITLLIENYNLFYDN
The following text describes a protein:
Function:
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
Subcellular Localization:
Cytoplasm.
Sequence:
MSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQQTVRFDLIISNPPYYQQGVECSTPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MSNKVVVAGVSIILVVGVAIGVVTTINHSRDAKGKLSPEMKVATSICAPTHYPDTCQKTFDSMNSTDPKEFVKKAIYAAEEEVKKFLNFSNSKIAEAKDNGLTKMALNDCKDMMQYAIDSLEATYADVDGSDLHNIDDRINDFRTWLSAVISYQQSCLDGFEHDRNLKETMEEAIVASSEHAANALTIVTKLIEILTKLGSELASPDTRRLFSVEETNYPSWFSTTDRKLIAKIDNSNLKPNAVVAKDGSGQFKTIAEALAAAPKNSINRHIIYIKAGIYDEYITVDKQYTNILIFGDGPRRTIVAGRKAVKDGGGITTWQTATFSAIGNGFIAKSMGFQNNAGPEKHQAVALRIQSDKSAFFNCRMDGYQDTLYNHANRQFFRNCVISGTVDFIFGDSPTVIQNSLLIVRRPMEGQSNMVTAQGKTRIDENTGTVIQNCRIVPEQKLFIDRFKFPTYLGRPWKPYSTTIIMESTLGDFIRREGWMPFATQNHEDTLYYAEYNNRGPGANLDARVNWKGYHKIDKATAMKFTVEAFLHSKENWLPSTGIPFTAGLRY
The following text describes a protein:
Function:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAARKRASAPQSVKEPSPKEIDKTRQSKYPVTDDPPIAPPKSGFIFKLILFFSIPYLYLIFYHYKIDLELRRSIIINAGLSLVGFFVTLRMIPVASRYVIRRNLFGYDINKRGTPQGAVKVPESLGIVVGISFLVLAIVFQYFNFTSDSNWLVEYNAALASICFMTLLGFVDDVLDVPWRVKLLLPSFAALPLLMAYAGHTTIIIPKPLIPYLGMDVLDLGWIYKLYMGLLAVFCTNSINIHAGLNGLEVGQTVVIAFAILVHNVMQIGASTDPEYKQAHAFSIYLVQPLLATSLGLLAYNWYPSSVFVGDTYTYFAGMTMAVVGILVDGIHNKRQGDEHLLLSTQNEL
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood.
Subcellular Localization:
Cytoplasm.
Sequence:
MFKVLVVEDDPALRKLFCTVLNKNGYKSIEAKDGHSALDVLYKEYIDLIISDIMMPNMDGYTLTKLIRESNNNVPILMITAKETFSDKQEGFRVGTDDYMVKPIDVNEMILRVGALLRRSQIINERRIVIGETTFLYDFLSVKYNNKELVLPQKEFYLIYKLVSTPNKIFTRQQLMDEIWGIESETDPRTVDVHINRLRDRFKDNKDFNIITIRGLGYKVVKQ
The following text describes a protein:
Function:
Metalloprotease (By similarity). Required for normal hatching and migration of neuroblasts. May act by degrading eggshell proteins at hatching.
Subcellular Localization:
Secreted.
Sequence:
MVSYWPVLIVLCLLPICHAKSYFADFVNGKGPFKQADALKFMDKMTILNKLQADILGIPQPDEFSALDFEDKIESKPDEIPYLFEGDMVLTDEQMDLIIKNVRDQYWARKSSTNEFLYAIRGKRSMTSFLSERWSFPVPYYIDTSSGVNTNAVLAGVAKWEQETCARFTRLNSYSSSSRQNALRFISGNGCYSNIGKVSRFPQDVSIGWGCTSLGTVCHEIGHALGFYHEQARYDRDDYVSILTQNIQDMYLSQFTKQSASSMVDYGVGYDYGSVMHYDQAAFSSTGGNTIATRDPNFQATIGQRVAPSFADVKRINFAYCNSTCSNYLDCQNGGYINPNDCNNCKCPPGFGGQLCDVAGTNSNGCGAGDITATSSIQTISASGALTCNYVIKAPVGAKVYFQMTAATFSRYSPCTTNYLEINYGRDFSRVGARFCASYPTISLSETNTLVVIYKGVNGARFSLNYRYDPVTFSTSAPTTTSTTTTTAPITVPTVSPTTTTTRQTTTTARTSTTTTTTQAPPTTTTSTSQCASWSACSAQCGGCGTQSRRCGTYVETVYCNTNPCTGGYCCRPFFYVTSFGTGYCRRPGADTPAAPQRYVEQRKG
The following text describes a protein:
Function:
Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MHPRRPNGFDGLGYRAGGGREEAAAFGAGFPARPDQAHWVTTPPDIPGSRNLHWGDRTPQLGPAAAPTPLGGSGSLHEDPYPGGGPGNGNDQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHARHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGILSEFTSLPRELSHKWSLRRIGEHLLLKALTYVVAMPFYSASLIETVQSEIIRDNPGILECVKEGIGRVVGLGVPHSKRLLPLLALTFPTVLHGVLHYIVTSIVQKCVLLILKRKQVQSQATESVSSVQSMLDAYFPELIASFAASLCSDVLLYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIKQEEGMFGFYKGFGAIVIQYTLHAAVLQITKIIYSTLLQNSI
The following text describes a protein:
Function:
Transcription factor (By similarity). Required for the terminal differentiation of sensory- and motor-neurons, especially GABAergic neurons, and for morphological aspects of uterine development. Plays a role in the cell-type-specific regulation of glutamic acid decarboxylase unc-25. Involved in promoting sleep-like behavioral quiescence, acting by modulating expression of transcription factor aptf-1 in the single sleep-active ring interneuron RIS. Plays a role in regulation of RIS differentiation. Required for the functional asymmetry of the ASER and ASEL chemosensory neuron pair, conferring the ability to discriminate sodium from chloride, perhaps by modulating expression of receptor-type guanylate cyclases, such as gcy-5. Involved in regulating postembryonic axon maintenance in the ventral nerve cord, acting in concert with LIM homeobox protein ceh-14, via modulation of expression of immunoglobulin domain zig genes in the interneuron PVT. May play a role in the functions of the excretory gland cell.
Subcellular Localization:
Nucleus.
Sequence:
MERDCDIVDLDQPSLGTVISIKDGSTPTDISTTSSTTEDKLCSGCGCLIKDRYIYRVMEDSYHESCLRCSCCQLSLSSFKKCFSRHGNIYCEHDHQMLYGKRCRRCMTLLLPTDIVHRVHFMYYHAQCFSCCSCQRPFNLGDEYHVFDGEVFCRNDYQSICNFQTISNPDPLMEEVVRSEIHRKTPKRPRTILNAQQRRQFKTAFERSSKPSRKVREQLANETGLSVRVVQVWFQNQRAKIKKLNKKDSDSGDTFKHGPGSEGRSTEDIRSSDDEEESVINLDADEVETSETSSYTDPIQKLYNMTSSQIYFPYHS
The following text describes a protein:
Function:
Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Nuclear translocation initiates after the perception of a light signal.
Domain:
DNA photolyase domain is sufficient for light detection and phototransduction; FAD-binding region regulates cry stability, cry-tim interaction, and circadian photosensitivity.
Sequence:
MTDKVRNRVQCWPALAQESSCVDFIPARQGATCGSTVVFIPCCGLTRGRRVLCQWFPCLSGGCCSQESSCVDFIPARQGATCGSTVVFIPCCGLTRGRRVLCQWFPCLSGGCCSQHTVNIIGEPPRPVGAPSFEFVEFGRLPSILSTELKLFQRAPVPEDFGIYYEGNADIARQRWTGGEAKALELLGRRLKQEEEAFREGYYLPTQARPDFLAPPSSMSAALRFGCLSVRMFYWCVHDLFARVQANNQLKHPGGHHITGQLIWREYFYTMSVHNPHYAVMELNPICLNIPWYEAKDDSLDRWKEGRTGFPLIDAAMRQLMAEGWLHHILRNITATFLTRGGLWISWEAGVQHFLKYLLDADWSVCAGNWMWVSSSAFEKLLDSSSCTSPVALARRLDPKGEYVKRYLPELEKFPALYVHEPWKAPPELQEQYGCVIGKDYPAPMVNLAEVNKCNANKMNAIRQKLLDQGGSTPAHCRPSDMDEVRQFFWLPEDVAAES