lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Template-directed low-fidelity DNA polymerase specifically involved in DNA repair. Able to extend primer-terminal mispairs, and to insert nucleotides opposite to a single 7,8-dihydro-8-oxoGuanine (8-oxoG) lesion and moderately extend from the resulting primer end, thus leading to both error-free and error-prone bypass of 8-oxoG DNA lesions. Probably involved in consecutive DNA replication cycles in the absence of mitosis. Binds preferentially template-primer DNA substrates or single-stranded DNA. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts (By similarity).
Subcellular Localization:
Nucleus. Note=Detected throughout the nucleus and at replication foci.
Domain:
The C-terminal region negatively affects catalytic efficiency for correct nucleotide insertion, thus decreasing the fidelity of the enzyme.
Sequence:
MDNGESSSTNNSSRPWESYNTVFTNAKAGMEGVDKEKVQRVVYEMSKGSKYFQNEERKEALMKQKIEHMRDRCAKLSSLDLSNYQKVVDKRILELEATRDLSRIWLHVDMDAFYAAVETLSDPSIKGKPMAVGGLSMISTANYEARKFGVRAAMPGFIARKLCPDLIFVPVDFTKYTHYSDLTRKVFRNYDPHFIAGSLDEAYLDITEVCRERGLSGGEIAEELRSSVYSETGLTCSAGVAANRLLAKVCSDINKPNGQFVLQNDRSTVMTFVSFLPVRKIGGIGKVTEHILKDALGIKTCEEMVQKGSLLYALFSQSSADFFLSVGLGLGGTNTPQVRSRKSISSERTFAATGDERLLYSKLDELAEMLSHDMKKEGLTARTLTLKLKTASFEIRSRAVSLQRYTCSSDDILKHATKLLKAELPVSVRLIGLRMSQFVEEIRNSDPSQGTITKFIVQKDSSRQAQDLDDNDSFDLDANKNCLSNDESGNVSFGSHETSSAHLKDVVEYEERSQIDSGKVIPNQECMKKEERLQILEGDSLLKKYKECKPDTSHSMNDNSNATEAVSVFPQTEPLYWIDGYKCVLCGIELPPSFVEERQEHSDFHLAQRLQNEETGSSSSTTPSKRRILGKEKVNSKPKKQKPDQKDSSKHIPIHAFFTKSNQNSNETQRK
The following text describes a protein:
Function:
May play a role in mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAARRITQETFDAVLQEKAKRYHMDASGEAVSETLQFKAQDLLRAVPRSRAEMYDDVHSDGRYSLSGSVAHSRDAGREGLRSDVFPGPSFRSSNPSISDDSYFRKECGRDLEFSHSDSRDQVIGHRKLGHFRSQDWKFALRGSWEQDFGHPVSQESSWSQEYSFGPSAVLGDFGSSRLIEKECLEKESRDYDVDHPGEADSVLRGGSQVQARGRALNIVDQEGSLLGKGETQGLLTAKGGVGKLVTLRNVSTKKIPTVNRITPKTQGTNQIQKNTPSPDVTLGTNPGTEDIQFPIQKIPLGLDLKNLRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDIKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLALALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPMREEEKMIPPTKPEIQAKAPSSLSDAVPQRADHRVVGTIDQLVKRVIEGSLSPKERTLLKEDPAYWFLSDENSLEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRAMLYSRAVRNLKKKLLPWQRRGLLRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGLSQAKPSLPDRNDAAKDCPPDPVGPSPQDPSLEASGPSPKPAGVDISEAPQTSSPCPSADIDMKTMETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPHNLHTGGGDTTGSQESPVDLMEGEAEFEDEPPPREAELESPEVMPEEEDEDDEDGGEEAPAPGGAGKSEGSTPADGLPGEAAEDDLAGAPALSQASSGTCFPRKRISSKSLKVGMIPAPKRVCLIQEPKVHEPVRIAYDRPRGRPMSKKKKPKDLDFAQQKLTDKNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGADGQEHKEDTFDVFRQRMMQMYRHKRANK
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MIYYSNYYGGYGYGGLGCGYGCGYRGYGCGYGGYGGYGNGYYCPSCYGRYWSYGFY
The following text describes a protein:
Function:
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIVLFTLLRWAPISPVFSMRTMHANLAHRGIFLPVMIVTLPLPVHLRRRFPAQMVLMLQWFAFGMFSVLLIIPWLLCVYRLVTHSPGRTKRIKQVLDDRTAPKTVVVMPVYKEAPETLIRAIDSVVDCDYPANCIHVFLSYDGCLIDESYLRLIEHLGIPITLESYPQSIDVTYKDARITVSRFKHGGKRHCQKQTFRLIDMVYADYLERHDNLFVLFIDSDCILDRVCLQNFMYDMELKPGSKHDMLAMTGVITSTTDRGSLLTLLQDMEYVHGQLFERSVESSCGAVTCLPGALTMLRFSAFRKMAKYYFADKAEQCEDFFDYGKCHLGEDRWLTHLFMVGARKRYQIQMCAGAFCKTEAVQTFSSLLKQRRRWFLGFITNEVCMLTDVRLWKRYPLLCLVRFMQNTIRTTALLFFIIALSLITTSSSINDLPVGFIAISLGLNYVLMFYLGAKLKRYKAWLFPLMFILNPFFNWLYMVYGILTAGQRTWGGPRADAATADEHTSPEEAVELAKAQGDELNVDLTTFRSRGDEKSVPIHPSEKIDGRFSAPELPDGYDSNLNDSNAALTELMTPLPSVPRIGIHTYPSSDSILTSDSLSSIHLPLKVEELTGDNDNMKPYPDRQPRDTSSLHQMQRTCSNGIVASDSCSSQDDASEMVNKPEILSPSAHILPHPSQATESSSGEDIYPLHLPSPHQHEAHFAPLNASTRGSMEGNTPEVQRPRRKLPGIPRPIRAQKDPESMV
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MGNWNFLGGVLEEVHIHSTVVGKIWLSVLFLFRMLVLGVAAEDAWMDEQEDFICNTAQPGCRNVCYDRAFPISLIRYWVLQVILVSSPSLVYMAPLRGALLRTYVAHIIVRSAVEVAFMAGQYLMYGFRLGPLYKCERDPCPNAVDCYVSRPTEKSVFMVFMQSIAALSLSLSILEIMHLCYKKIRKVTLDFCAKKGKERDDFEAQSDKVMPICGRASQKRSTLSVQNDIELIERKKCSNIYPELMKTSMFLPPQLATQRFYGQSAFAEPRPSFPNSQIYSKEKSEGFYLPHSDHHYHISDFILKFCNKNQIGFIVCYFVFAPEGDFVHFR
The following text describes a protein:
Function:
Serine hydrolase. Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir (By similarity). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (By similarity). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1.
Sequence:
MASPTKAVIVPGNGGGDVATHGWYGWVRKGLEQIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHQVYALILVSAYTSDLGDENERASGYFSRPWQWEKIKANCPHIIQFGSTDDPFLPWKEQQEVADRLDAKLYKFTDRGHFQNTEFHELIRVVKSMLTPAL
The following text describes a protein:
Function:
Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDTAPASPEPFLVTPQAEVLEELIQAQMGPLPRLAAICRLKRLPSGGYSTTDDLHLVLERRRVANAKERERIKNLNRGFAKLKALVPFLPQSRKPSKVDILKGATEYIQILGCVLEEAKVSEKQSPEEQTHSGRPSDPHVSSTRELLGNATQPTSCASGLKKEEEGPWAYAGHSEPLYSYHQSTVPETRSYFTH
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner. Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome membrane. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network membrane. Lysosome. Membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MEDYKYLFKVVLIGNAGVGKTCLVRRFTQGIFPPGQGATIGVDFMIKTVEIDGLKIKLQIWDTAGQERFRSITQSYYRSAHALILVYDVSAQPTFDCLPVWLREVEEYASPKVLRVLVGNKVDRDDREIPPAVGEAFSRMNNMYFIETSAKDCSNVDKLFQEIARELIQVEHFLLFQ
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MLLEKPEDVKHENSSGTVCAIYGVDAHPTLQLFATAGGDNAVKIWSLQPPPEGGIATFELLATLANHQQAVNCVRWASHGRYLASGSDDQLVLLYELQSGAAAPVPFGSNAKRNKQNWVRCSTLERHTMDVADVAWSPDDRMLATCSIDNTILIWDVGVGGFSEVMTQPLQTLTGHNGWVKGVAWDPVGKYLSSAGEDKTVRMWKVADWQESDVVTEPFEGCASTSHFRRLSWSPDGSVLCATHAFSSKKNIAALLNRGSWTNDLKFVGHQSVVTSARFNPKLLVTKADPDKQFACCAVGGDDATFGGDEIGTPISDAQQSKLLQAKYGSRAGITLASTLVENPIQLQDSSANNPASSQNNIRNILGPTIVSPTASDVTLLDARMASTSGKEPSSAPGHSEKTGSGPKEKPAAMSSNDTSSKSLKMEVKKNGADGVSLKRKREVDRPPTQAAAVVVKSREVVARAPKLLNERLQFSVEIDTSTHSGSSGSNSNGKTSNGLMPSKTVVEATVHNLKNPQPEEIIGNASYWAIGVHNGDLLILNSSGRRLFPCIALGSAISVMECSVSDSPYLLVILVTGDLKIWDLEARKLILSSSVEAITNIGPLRRLQNASGYGRTQRGIASAMLSGMADPLMQRNVTRSHLEHQVAASIVLKSSTEYRYWVQAYARFLTHDEDVTRLDDLCAEMMGPFHAPSTRSTADVRDGEWAPMVLDLVKRDVLKSHILPTIAANRALQRVVTKYQLMLSEIEAREKEENDENES
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLTEHFVAAISASTKPNTGVTKDAGIFIHEYQPLAAQRHVFKKSATAPNGIAVSSSHVFAAQAEKAIVHVYSREKGNQEAVIPFPERIHSIALAAQDTVLLLGTESRLVSTSTSHLQPVTSIAVDPSSNFFLTGSSDAMVHVWALPAILSFSPDTPRTPVHTLSTHRGPISSLVCGHSSTSANIAISTSGDKSAIVWDYHNGHALRTYLLPEAPTAVTLDPADRAFFVAYADGSLQTIDFYDDVQSTLSTNLLHDPSSSHRPVQPPPKTRFSAESQKLGGALSLTLSWDGTTLVSGHASGKVAAWDIAKSNYLSTLANLPGPVSNLQLLPPTGFPQDPEQLFKVHTVVKPKHDPGTSAGGSGLIPPGYTLTMQLTGRLRTERASATDTMLPTKTAFEEALTHPSFPAGMLEESLAELESWNSASKGATAPASDFMALDDDSNATSSDAHLTEVKELKKQVASLQRIQKVTFTQLSELRTEREYFLSKEKRRAERAKARAKKSLGHTNGHANGDVEMTGGDNSDDSDSDDA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MASGFGESTGRSPPSPSYFNNNNNNDAANFECNICFELAQDPIITLCGHLFCWPCLYKWLHFHSQSRECPVCKALVEEEKLVPLYGRGKSSTDPRSKSIPGDNIPHRPAGQRPETAPPPETNHFHQHGFGFMGGLGGFAPPPMATTRFGNFALSAAFGGFIPSLFNFQLHGFHDAAMYGGGAGFPHGFANTFHGVHAHGFPLRTHQGQQDYYLKKLLLFVVLCVVLAFIWQ
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
MTFPYINFVQSACLVSAVLQSSVAYVPLCKEFLDLSEMETNLNCIACHLQERNREKTEDISPLHTCIFLGGINLTLLDNSMSAQQFLKQKATSNSASGNEDAFYVADLGDIMQKHCQFMKELPRVKPFYAVKCNSTREVLQTLAYLGTGFACCSTAELDMVLRMGVPATDIVYANPCKQISHIRYAAEHGVRRMTFDCESELFKIAASYPQAEMILQIVADNRDSWHSLSGKCGVHINECENLLEKAKSLNIQVFGVSFHTGSGCKNTHSFRKAIEDARKAFDIGKKLGYKMRILDIGGGFPGDTEFLPTFEKFAEVINKSLDQCFSCNEDVEIIAEPGRYYVSSAFTAALNIVTKKEVTKKDGEGRRTLSYILNDGTFGSFLLNYLQIEEKNLKPFVGKDFDTALELFPSILWGPTCASEDEILNNVDLPELEMGDWIFFPNMGAYTISMNSNFNAFAAPKVYFVLTKEKSL
The following text describes a protein:
Function:
Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLNNYNSLAQPMWQNGPAPGEFYNFTGGQTPVQQLPRELTTMGPYGTKHSTASSTTGTSVLGIRYDSGVMLAADTLVSYGSMARYQNIERVFKVNKNILLGGSGDFADIQSIKRNIDQKMIEDQCCDDNIEMKPKSLASWMTRVLYNRRSRMNPLYIDVVVGGVDNEGTPYLANVDLRGRSYEDYVVATGFARHLAVPLVREKKPKDRDFTAVEASELIRTCMEVLYYRDTRNISQYTVGVCSVNGCGVEGPFQVNENWTFAETIKGY
The following text describes a protein:
Function:
Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTNGDNHQVKDSLEQLRCHFTWELFIEDDEMPDLENRVLDQIEFLDTKYNVGIHNLLAYVKHLKGQNEEALKSLKEAEDLMQKEHANQASVRSLVTWSNFAWVYYHMGRLAEAQAYLDKVENICKKPSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKALEGDHENPEFSTGYAISAYRLDGFKLATKGYRQFSLLPLRQAVSLNPDNGYLKVLLALKLQDNGQEAEGEKYLEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATKGQPRGQNREKIDKMIRLAIFHFESAVENKPTFEVAHLDLARMYIEAGNHRKAEETFQKLLCMKPVVEETMQDIHLQYARFQEFQKKSEINAIIHYLKAIKIEQTSFIRDKSINSLKKLVLKKLQRNALDLESLSLLGFVYKLKGNMNEALEYYERALRLAADFENSVRQGP
The following text describes a protein:
Function:
Required for the proper orientation of spindles after the establishment of polarity. May play a role in interactions between the astral microtubules and the cortical cytoskeleton. Required for asymmetric forces on nuclei and spindles. Acts downstream of the PAR signaling as an intermediate that transduces polarity information to the machinery that positions the mitotic spindle, possibly by regulating force generation. Regulates gpr-1/2 asymmetric cortical localization during the first embryonic cell divisions. Acts antagonistically to the gpr-1/2 signaling pathway. Regulates mes-1 expression and/or localization pattern during early embryogenesis.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Note=Enriched at the cell cortex during both meiosis and mitosis. Enriched asymmetrically at the cell cortex in 1-cell embryos. Localizes at the contact site between EMS and P2 in interphase and is excluded from the contact site during prophase.
Sequence:
MSADYSSEKFKATHLFDEILWHFRSNLSLKTNRRGLATAENSFSGKEAVDFLMIEMPRIIPNNVPERDKMQKFLEFMMDMNVISEAFPKKVKQRRPFSESRIYLFMKTLDELKHPKPRSRRSASFSGARKSAKVAQPASPAATMHRPPKARLPRRLSRSNGNIDKAGIDNSSGGVENHGFDDHKDDEIPKKQRTPKILNRSLESICTEEYTEKREVSEMKEKVYDWLPFFKSRRNHTKVNQPTRRSASLDRNHCVLEQEKAEAALRSQKVTTPPIREAPKDVVFMHPQGPLPAVPSRYQNHRTSIAGSNPALLSRGRMYESIMRRSSVVPVADSVQANNECSFWKTELLGRLEQIYDRTLPCEWASKVDGYDIQWNMIEIDHADGIVKSRCQGLQPDYPQTVIQFMDYLVRYPFVTHKKMDTGLEYNVNRIFITLVNRLEDLNAPLQFDECSLIVNLLCKIDSFAAMLDNGPARRWSKVMISSSASSIEEAGLMVDGFSRDLPACGIRASKYRRRALSPFDNRVNLEIQDEKSYEIREQWLIEAIQLVLLSLPTSRRRKLHKFVTFIQSIETNAVFDLADPSNGSSNNREAAIIGLWTGVCSKCRKQQGMLITAVLLANFQSLFAVPVEFIEQVKRLECEEKDRYSGPRYAKITRSRNDWQPPVPDKPQASPAVFKKPLREVACEKTKKGLFTRLLRK
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MIVKIRATTGRIYKLELPQNATVEQLKQAFKKVIGFSQFKVKIKFIYLAYIMEDAKTIESYNIKDTEYIVASLENKNKQDLFDLTSTLYPHNYMYTSLPTNEPLPNFSDSDSMSSSGEDEESESDGFEYCESIEGLQELGFLKSDCQAAIKAAMGNFQIALAYLEAGIIPSKGDVDNFNKFIDNVKANIEVLDENPDHLNQVLNDLEKILPEQGALFRAKPELLIQRLGLNPKDFDLEEIRNTEAIDRITAENEASNPYSPNDEEEPIPDQDPLSKFTPEEQDAIKRLCELGFDIHLVIHVYEACDKNEALTANCLLAMND
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Sequence:
MNKIKMKNNYIERKKYSIHNLVKLINEKKNIENSKKNELSEGTTEKKNVSIENNDVHMNSKKKKKKNRTDKENGHIKNEDFINSSSNDENDCTNNEENIVNDDQEELTDDKNKLCYDHEIINNGSSDDNEIKLFMFDYKECQNKKCSCKKLYRFKKIKKVQMNKKFKGIVLTPFCEKYFSIDDKYTIENYGLSVVDCSWKSIDLLKRIKFSNQRKLPYIIAVNSINYGKPYKLSCLESLAFCLYVCNYNKQCNDILNIYKWSVNFTNLNKELLDTYKLCNTHDEIKNAEEEFIQKYLHEKEQNKKIDEYKIIYEDDYI
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic UMP-AMP (3',3'-cUAMP) from ATP and UTP and plays a key role in innate immunity. Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',3'-cUAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MSGKMNEWESLNTTLNRFTDNVVKFRRDSRTKALKCWRPIVDGIVDYVKRKDDRFHALSVFHKGSYYERSKVGEPDEFDLMLVMDNLELYDEPFEEDDGLSEPPIGFTTVMIDQGEEKPWKRDECVNRRGMLNATRVKAVFKRLADEAIQDMKSKGHWRNVTVKSGGTAVTLKISKDGREYSVDLTLGIKDNTWPEDAEEWKTRQRKGWPKRNLVHDIHEMGCHLVTKQPKGHSPIEQERGFLWCYSFSEAEKKLFLQGEQGEVNSCRRQVLRILKALREELELQPLKSYHLKTLLLYECESQPSARQWSKDALSERFLDLLKRLEKCLRSKECPHYFIKDLNLFEMLNPEKCDELADRVNKILKQPGQVLIRLIK
The following text describes a protein:
Function:
Putative transcription factor. May function redundantly with odd and sob in leg joint formation during the larval stages, acting downstream of Notch activation. Acts in a hierarchy during foregut and hindgut patterning and morphogenesis, antagonizing lin to relieve the repressive effect on bowl. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus.
Subcellular Localization:
Nucleus.
Domain:
The C2H2-type domain 1 is essential for binding to and repressing lin, while the C2H2-type domain 2 contributes to lin binding.
Sequence:
MFAVMRIDNDDCRSDFRRKMRPKCEFICKYCQRRFTKPYNLMIHERTHKSPEITYSCEVCGKYFKQRDNLRQHRCSQCVWR
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MDQFTILGQGAENIVYQYIGDDPTLKDKVIRIRKPREICEITKNLILPYNDTDWTPLKKHFIKQQPYEIGDQKCLIMDNLLYNIAFACGNQTQNILTHFINEINDPKNQRFFMISLLKAQRKLKKEDKDIYKCSKEEIDPIISKYDPRKFYNCNVQSLFDSIIDLSVVPDSNLKLFNNQQQRVQNIPEFNIEDIAKIISETLLQEGIIQQLNGFFQMLSQMNFTIEQAFEAYEQLKQRNLTNKQFSEIVEGKCQDPEISKLASKLQTFSSLQALSDLSIVGSFRKEGSGKFIEIGNQKLFYQYTIIDCDLKPLNKITDYMSTIDELIKLRDYYNSLK
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRKYLSGHNRPLTHVNTNYDGDLLFTTGRDKKFILWRVSDGTQIGLYECSGAVYNSDVTYDSKRIVCSSAANKVYLFDVYTGEPLKIIEENGPVRFVEFNKDPLNQDKIVVAHDRLKSDHKRSIKLYDLKSDNLIWKQDHESRCIQVRWCFFDKLILSAHENGEIVVWNAEDGHLIRKFQAHSKEVTNLSFDKDRMLMLSSSLDGTAKLRDGVNFEIINEYKTDRPLNTCDISPLFKNENNPKNHIILAGGQAAEHVTTTASGEGKFQTLLYDIIHSNELGSIKGHFGPVHSIKFLPHGDGFVSGGEDGFARIYHFDNDYFIGKYD
The following text describes a protein:
Function:
Binds to ssDNA, binds approximately 5 nucleotides per monomer, binding may be slightly cooperative. Inhibits the endonuclease activity of XPF. Stimulates reverse gyrase from S.shibatae strain B12 (rgy).
Subcellular Localization:
Cytoplasm. Chromosome. Note=About half the protein is soluble and half is probably DNA-associated; distribution does not change upon UV irradiation.
Sequence:
MEEKVGNLKPNMESVNVTVRVLEASEARQIQTKNGVRTISEAIVGDETGRVKLTLWGKHAGSIKEGQVVKIENAWTTAFKGQVQLNAGSKTKIAEASEDGFPESSQIPENTPTAPQQMRGGGRGFRGGGRRYGRRGGRRQENEEGEEE
The following text describes a protein:
Function:
Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own).
Sequence:
MIINRLFIIIVLFFVNVNSKIISESTLNSCQGGTIQIAESIPLGLDISTNLSTHDAWMDLITNAQESIDLGFFYFTLLGGSDLDPVYGGQLGIDIFNAIVEAHSRGINVRIVQNEPSESFPDTETQTLAKLGIQVRSIDWVSLVGSGVLHTKLIIIDESSAYVGSANADWSSLAQVKELGIVLKNCPTMVADTEIAFQQYWNAADFTSLPINDWGSNYQALFNNTNMASLSLNNNNNNNNKNKNNDNDGSGTNQMYEMFLAVSPPQFQSTYRTGDIDALMDAINNADQSICITVMDYTPTTLYNDPNTYWPLIDNALRAAAFNRNVQVRMLISHWNYTSPIIPQWLHSLNQVDNIQVRWFVVPDFSTNPQIPYTRVNHAKFMVTEKQSYVGTSNWSQDYFTVTGGLSYNVFNNDFTNQLQSIFNRDWNSPYTQPIQNF
The following text describes a protein:
Function:
Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Lipid droplet.
Sequence:
MKNVFLTGGSGFLGKYIIEELISNGYKVFALSRSETSNKVLSQMGATPVMSSLHDEQGLTEAIKGCDIVIHCAAKLETNSESVQELYKDNIDATELLFNICNQSSTSSVSVFCFISSEGVIMNGENINNATEDTPYPPIEQLGWYNKSKAISEQFLLATQSSMSRMKTIVIRLPLVWGSRDNVLDYLVGLCNKFQWFWIGGGKNYLSIVHAKNASYGIRLAIEKGDNQDIFHLTDGESVQYRKFFTDRFKKKGVSTNKLHMVLPTPIALSLVWIMALIWKLFNLKGLPLLTKTGLIYSSKNFTINDDKARLKLGYTNKINYNQGMDEL
The following text describes a protein:
Function:
Involved in chitin degradation. Catalyzes the oxidative cleavage of glycosidic bonds in chitin via a copper-dependent mechanism, leading to oxidized chitooligomers with degrees of polymerization of 4-6. Is not active on cellulose.
Subcellular Localization:
Secreted.
Sequence:
MHAGRKTAVLIGAALAPVIAVSLPAASASAHGYISNPPSRQAQCAAGTVSCGDITYEPQSVEGPKGLTSCSGGNSRFAELDDDSKGWAVTPVPRNATFSWKLTAQHSTSTWEYYVGGQRIALFDDGGAKPGAVVDHQVDFGGLDGRQKVLAVWNVADTDNAFYACIDVNVGG
The following text describes a protein:
Function:
May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation.
Subcellular Localization:
Secreted.
Sequence:
MDNIPYFLATVLIFSLGFRIEEGMCQHYYLLRPIPSDSLPIVELKEDPDPVLDPKERDLNETELRAILGSHFEQNFMSINPPEDKHAGQDELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPPKSSHLTVLRWRCVQRKGGLKCAWIPVQYPVISECKCSCPN
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MNVIVSLLLVLALTLLHTGLVSSHKWDYIHEDKWPTACKEGRKQSPIALSRGIAEEQAFSSLIFEQYDITYPVQSKNNGHSVEIRLHVQNQPTVRGGGLPDIYRLDHLHFHWESEHTMDDRRFPLELHLVHYANKYANLSQALQYSGGVAVFSVLFYLSPDDDVQFQPLINVIDKLQDKINSIQEMHVKVDDYLPRDRAGYYRYNGSLTTPDCTEGIIWTVFTNTLPISNSQVKSFPMLKTDREGNILQNYRSLQELNGRRVHIRSSPVSGASTYLIYSRIFYFVLFIVLSRFS
The following text describes a protein:
Function:
Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Recruits NR2E1 to repress transcription. Has some intrinsic repression activity. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Cell junction. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Colocalizes with MTG8 in discrete nuclear dots (By similarity).
Sequence:
MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL