lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
Miscellaneous:
MISCELLANEOUS: The major isoform Sp100-A, has a calculated molecular weight of 54 kDa, but exhibits aberrant electrophoretic mobilities, with an apparent molecular weight of 100 kDa; MISCELLANEOUS: [Isoform Sp100-A]: Major isoform.
Subcellular Localization:
Nucleus. Nucleus, PML body. Nucleus, nuclear body. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent. Accumulates in the cytoplasm upon FAS activation; [Isoform Sp100-C]: Nucleus. Note=Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.
Domain:
The HSR domain is important for the nuclear body targeting as well as for the dimerization; Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Sequence:
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPLESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHRSKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCIQSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCEEHKKKNPDASVKFSEFLKKCSETWKTIFAKEKGKFEDMAKADKAHYEREMKTYIPPKGEKKKKFKDPNAPKRPPLAFFLFCSEYRPKIKGEHPGLSIDDVVKKLAGMWNNTAAADKQFYEKKAAKLKEKYKKDIAAYRAKGKPNSAKKRVVKAEKSKKKKEEEEDEEDEQEEENEEDDDK
The following text describes a protein:
Function:
Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The Ripply homology domain and the WRPW motif are both necessary for its transcriptional corepressor activity on the transcription activator TBX1; The WRPW motif is required for binding to tle/groucho proteins.
Sequence:
MEPEAAAGARKARGRGCHCPGDAPWRPPPPRGPESPAPWRPWIQTPGDAELTRTGRPLEPRADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDDESTESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGPLPQGVSSRGGKCSSSK
The following text describes a protein:
Function:
Electron transport from formate to hydrogen.
Sequence:
MNRFIIADASKCIGCRTCEVACVVSHQENQDCASLTPETFLPRIHVIKGVNISTATVCRQCEDAPCANVCPNGAISRDKGFVHVMQERCIGCKTCVVACPYGAMEVVVRPVIRNSGAGLNVRADKAEANKCDLCNHREDGPACMAACPTHALICVDRNKLEQLSAEKRRRTALMF
The following text describes a protein:
Function:
Required for early events during cytokinesis including localization of cytoskeletal components to the cytokinetic ring.
Sequence:
MVSRSNEGPEAPHPASRTPGAPAKGRLTRLGSSPSKRDDKAKDDRMGKTSAKDVAELKDYQLGDCLGRGAFGSVYRALNWNTGETVAVKQIKLADLPKSELRVIMLEIDLLKNLDHPNIVKYQGFVKSAETLNIILEYCENGSLHSIAKNFGRFPETLVGVYMSQVLHGLLYLHDQGVIHRDIKGANILTTKEGLVKLADFGVASRTTGLSESSVVGTPYWMAPEVIELSGATTASDIWSLGCTVIELLEGKPPYYNLQPMPALFRIVNDDHPPLPQGASPAVKDFLMQCFQKDPNLRVSARKLLKHPWIVNARRSDSVVPKKSTEYEEAVKSVQEWNEALRSPESNALRRGTRNENQNPPSLRLDTRHTPTKVTLPSPVSRIVADKFSSPSSGEEDNWDDDFATAISPSALQLPHLRPHDNFGGMLSSEKLKAFASLDGTVLKSDESFEESDDPFKGSLLAGEHDPLKTIRPPPSQQANSGTSQSQNGPYGAHMRRGPPLNTAITPVYGGQMLQNSSSPIRQQRPPLFYKENSVEDYSDLISANEDVLDRKISAFQESDEHKDLADTGRSREVIRYQSSYEQEDTPRIGRQISVKRYRGTVEIQQFAENEHDEDFSDILGVDGVTLDKAESDDGSNKSTLMLNTKLSNNSWLGDLDDEDDPFALLEEGLDETDLEANIARDKHARLRSQVEGLVGSLKTSQDEEVLGDISEQLLAVFCDFPETKNIIISAHGMLPILEILDLCRRRDITLCLLKIVNAIIYDDYEIQENLCFVGGIPIINEFAAKKYPREIRLEAAAFVQQMYQTSTLTLQMFVSAGGLNVLVEFLEDDYEDERDLVLVGVNGIWSVFELQGSTPKNDFCRILSRSSVLDPLSLVLSRVLDEEGELAEVVEGRIANIFFIFSQAENHVKEMVSERTVLHRVLKELKRMTPAHQITMLKFIKNLSMLSTTLDSLQNSNAIDVLTDLLRSTIKRPHFREVSNQILNTIYNMCRLNKSRQEDAALNGIVPLLQKIVKTERPLKEFALPILCDMAHSGKVGRRELWRNKGLAFYISLLSDPYWQVTALDAIFIWLQEETAKVEEHLLENRYDQPSFTDAIVRCLTLSKANAFENILEPLQKLLRLSPPIASTLARPDLFSRLGQKLHHSKAAVRLNLLRIISSICDSSEQQGGLLASYGLLDSIRELEHDPAILVRDMAGKLIQSSERNDSYGLCKLKPNVRRGSTSATSPGLLANQSAPVTPQLSRQNQSKGYYDSRETQRRPRSAISGSALALRPGSRDGPTPGIVGGANGSAGASRNRIARGVSNRLSHIELLPNDDDRIPSSITRRSSVLPRRRRLTQFEAERGS
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MDRRDVVYYSPRCPYSVDFVNKLNAESKNLASTVLVNIDRQRPVHPISQTPSVVSDHQIYGGSAAFQWLKKRHGGSTRAGPSTEKRATSDEMFAPMTTSSFTSPSPGLTFTPYDEEPDGMLGSSLKSLFEVLKELLNDVNIIATSSGLKTIAMDFSQCTLCHVWLDAEKFEVFYCPSPIVIGINIQNMYKLLKTVSSSDVLTMQIDEDNTNELEIIIQNSDRKAKTFFKLKLLDIDDQRISIPDVELTTQITMASEDFKRLVKDQLSIGQVMRIHVKGSQVIFETSGDFASQKTILETESGADQEEIDLSFSLKILALFTKASSLSQTCTLFMQPNFPLVTQYAIAALGELRLVLAPKSQDI
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPNQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMIHVDKAEGTTYRDELLTKIIDICSQANYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMAMLLDNAHLIASNTQRNGICEVLYAAAWICGEFSEHLQEPHQTLEAMLRPKVTTLPGHIQAVYVQNMVKLYASILQQKERSEEKEGAQEITQMMIDRLPQFVQSADLEVQERASCILQLIKYIQKLQTKEVPVAEEVIALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPPSDSDSEDEKPKTIFHDEEQRHSKHRQPAFDEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGIPMSDQYVKLEEERRHKQKLEKDKKKKKQKKEKKGKHRRHNSLHTESDEDIAPAQQVDIITEEMPENALPSDEDDKDPNDPYKALDIDLDKPLADSEKLPVQRHRNAETPKSPEKEEIPVIEKKNKKPKKKEKKHKEKEREKEKKKEKEKEKKGEDLDFWLSAAPSPASTAQSSIEPSINTVMAVAEGYEEPKKEEREDEDEDEEKKSSKHKKKKHKKEKEEKSKDKKKSKKKKHPSEDEQVEAIQNGTLDDEPLPPMSSYCLLAENSFIKMTYDIQGNLQKDSQVTVSVIFENKSGSFLKSMELNVLDSLNTKMARPEGASVHDGVPVPFQLPPGISNEAQFVFTVQSIIMAQKLKGTLSFIVKNDEGSTHEKLDFKLHFSCTSYLITTPCYSDAFAKLLESGELSMNSIKVDGISISFQHLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLDEMRETLANC
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MIVDYQDVDTVISGVDYFSSYNGNIENENCKLSDLFEQNVNNQFFQPNNTSLPPPTNQQPQPQPQQWDLMEDENCNSSFENSPQQPTSPLLISSQTSYPSDLSSNSSISHSPIENQLLDNNLDINNYLNKINIFNNHFQNSDLINTTFFNQFENNNYINNNNNKENNSYFYNNNVNIPNNNNLNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNTVYNNVNIPNNNNFNLNLSNNNNNLNLTNNNNNKNSVNNNNVNISNNNNNNNFNVNLSNNNVNISNIPISNYYQQAAQTIFDDNFQTIQFNKEYPLNEHISQSTNKRMKISHHSHSLSNNNENSLSQPYFNNNNNNNNENENVYNIVNEQNPTFNPNQSNTHQQQEEQYQQHEEGQEEKEHEEEEKYQKQKPKIEIEELININLIKEKIEKLKNKFENENVICSEFLEKCFKFSSFPIFPIVESKLKFYQFEIDFSFSSYIESQKLDKIGLPSFKRPVQFLNTFYTQEIVNLDQELITRSQPIHDFIECISLIRPLLSLSSSSSSSSSSSSPSSSNELNSKLNMVQSVFNVVKSYQKTNTANVILQVLKKYAKEFKSRRILSEQQETNMNLWFDAHVNNPYPEEDEKVILGAVNNLSKSQIDNWFGNKRMRDKSNKKSL
The following text describes a protein:
Function:
Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val.
Sequence:
MNSGPLEFTVSANTNPATDAVRESILANPGFGKYYTDHMVSIDYTVDEGWHNAQVIPYGPIQLDPSAIVLHYGQEIFEGLKAYRWADGSIVSFRPEANAARLQSSARRLAIPELPEEVFIESLRQLIAVDEKWVPPAGGEESLYLRPFVIATEPGLGVRPSNEYRYLLIASPAGAYFKGGIKPVSVWLSHEYVRASPGGTGAAKFGGNYAASLLAQAQAAEMGCDQVVWLDAIERRYVEEMGGMNLFFVFGSGGSARLVTPELSGSLLPGITRDSLLQLATDAGFAVEERKIDVDEWQKKAGAGEITEVFACGTAAVITPVSHVKHHDGEFTIADGQPGEITMALRDTLTGIQRGTFADTHGWMARLN
The following text describes a protein:
Function:
Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix. MCUB is required to limit mitochondrial calcium overload during stress. Acts as a dominant-negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating. Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism. Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference. Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MPGALSGRRMLPSGLCLGRWQLLRTIRARGRGDPRELPSTPQVLCMKLYGNPKYHQALHYGTVEPQDEITVTYKHGLPLVTLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIKTAAIITADGSEIPASTLMDTLLMTDFKLIINKLRYDIRCHKKEEPSGEHMTELENTKSLVHRLFTILHLEEIQKRRERHLMAKIDHLQEQLRPLEQVKAAIEARSEANTSGLLWAGLALLSVQGGALAWLTWWVYSWDIMEPVTFFLSFANSIVFFAYFIITRQNYTYSSLRSRQFLQFFHKKSQRRCFDVEQYNKLKEDLAEATESLESVRRSLRLRIQGEEASEKN
The following text describes a protein:
Function:
May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol.
Sequence:
DDDTTLFTGMIYLGCAIVNAPRSELEVNRNMVILNNQSNQAVQVTLAVPSHSQGAVYLLDPSTNQEIASFCIQQILFCARGPNDTKESKCFAFTCSHSETVETAIFQCHVFRSDDADNVGKILYNFATAFRRTLKAQQQPATSTSQMATTSSTTPATSAADCNLFHFDVTLDIKELDPRSQTYVSCPKDKNVIKMRCNVPKKVVIHISQMSGLQSIKLDKCFGVLLGAGRNIKTSEMNLLEIEDFNKSVDCSTFNIAATWDPTLSQYNLINAETPKDSRMFMTVAVDVVMDLIREPIRFLFEVKVKVFPTNQKFWYFTNKSLYNKFAVRVKEVGGDNDDGGDDDIVRKCVTTSPPPSSSSSPSSSSPPPPSSSLPPSSSPLPSSSSPSPDNDEPLLSGSGAVSKEVTDEALLDSWKDVLIKWHQNVSQRPKTVEGLVRRGVPEALRGEVWQLLVGCTDDQQMFETYRLLIAKDSPSEEMIQRDLNRTFPAHEFFKDVGGGGQESLYKICKAYSVYDEEINYCQGVSFLTAALLLHMPEEQAFCVLTKIMYDYKLRDLFRQDFEDLHLKFYQLERCMEDQLPDLYDHFMDLGLEAHMYASQWFLTLFTAKFPLFLVFYILDLFISEGMSTIFGIALALLKMSRKDLLTLDFEGVLKYFRVHLPKKYRCDEVSKEMINMAISLKPSNKKLKKYETVFKTFRESQLQQEDPVDRLKRDNKRLQETNMRLERENDDLASELVNSKIQLRGELDKVEDKYDYVNKELLLCRSQLVEVEEEKKRLEGEVGQLKDLCRRESEQATSNNAKNMNIIQDYKQICSELSMRIESLSTSHKKELKLIKEVVERCASCRDVIVSRDGSWKDPPTSQQQNAPASESADLSNAIQSEQAIRDLELELAQTKLALVECECKNQELIHQLTSSSSSSPTPPTSSASSSLSSSSSSTNKNNSWLQKTLTSIKEATTNVKAGGITFGGN
The following text describes a protein:
Function:
E3 UFM1-protein ligase that mediates ufmylation of target proteins.
Sequence:
MTSWADIQKLASDLQRVQLTQSSKKLSEVNCIEVLQKLIASQQIDVVYTRDGHTYVTKKHLETEIKNECVAAGGRAPLTDIAVALNIDFDHIERTARLIVSSDDEFTLSNAELFATGYSLCRTKISISVNTCIASATNFALFSMNKSLLIEKLSSTDFEGVVDGDTIYTSSFLDARQLVLRAVLVALTKVTPISTIQKRVGLTPKRFWIAFENLQALGEVPGTLIGSRTSPACSYRPKMYDYLVKTCVTNQYRQNEFLQMSTLKTLGLDSKTALEEVLGASEVKKLVNLNSIYMSKELMEQCVQTVQGEARNITLNTDYIVFVPDDIQNSGIAEIRMSLQTLNLPLDTADEDLIGEKIASTEKDTNFSDGFVYNNSILTEALKSINTQIEAKAHQEVEKIDVEKKKQCGSKAPAKVQEDTDDWGDNKKGGKGGKKGGKGGKNGGGGGKGATSSVPTGSGTVQVNSEELEEWLRESQTVPEEILTVVVETLHQDATSALRKQVQEIQALQLVVNAANSKKSLSAIGDKCRQLYDSFNTFEAGTTSFADPLGTDLRQYLLKTVGVDLACAILSYAIGIDNVHQLKEKQRDETIESLPEMVREPIRALFASLKSTDEDAVEKFHDAVYDCSVPSATSLSLRKIDKKGRAEVGVKVSADLCDQLASQSDPATTLLLSVLYLFSQAGRPTTASGKFVAQLIAQMKDFCPTNTFELLQSCQKGVVTCIKNQDDDVAKEILSEDIEKLKSAVLQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MEDQRCDTMGLDLNLELSDPLSPNLAQTLEEILANGAGTIHQEQLQQTEAAVSRPSPRYHWSLRQFQFPPEAMQRNNNNVTVRAEPIVDRGSEALQARDGIMVAEERNIDDSISCNGSAGDLLDNPMQNGKDVEKWSGNGICVFECNICLGMARDPVVTRCGHLYCWACLYQWLHIHSDVKECPVCKGEVMDTSITPIYGHGSNSNEMVKEGESGQGIPPRPHGQRIESLRQTIDRVTNTNPFDIDAWISHIHNRIDEMGGSPSSQNLGGSHVTLADDPSSLTRGILNPRGMHREGLLAQTPVLTANMIGPEQETVDLMQDISSNFEAASRQRLLSLQIMRLQVQRIVSYARFLSAINSAERLVQAYFLGHSTRRNHIQLPPVDDRDSNSSIGAVIQLGSQTVDGAAETDSIGSRREADAPRASDGDIGMFPATRRQRLN
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERNFMGLDSKDAIFNKDLELEGCKQPDVFESFNNHPEREIEVAQVQHATKPAVPVTMSNPFYRPVFSGAPVYSQLLNPWYGSKVASVPAQLTIFYDGMVYVYDDISPEKAQAIMRLAGNGHFVATADAPQQRTQAQGPAPTSPASPRPCSPVSSPMSVSSHYVGPLTDGPHSETEAAKRIMSSLGQAMQSAIPQARQASLARFLEKRKERVMASAPYSLGKNIMDCASNGNAAVVAGE
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MYNTRRSAYMNSCSTAMELPPQSLHQNWQDTEYVNTTCSSDMNSDMSMYNDDKDDPFYEDEGSGGGTSGGGKKSSRKRANTTSSSGGNEKESKRTANKVCRVCGDKAFSYNFNVITCESCKAFFRRNANKEKEIRCPFNEQCEINMVSRRFCQRCRLTKCFAVGMKKEWIMSEEARLEKKQRVEENRERRLQDAMNRALEEACMEDESENSYDEAPAPSHQMSVRQYLANDDAPHKSSDEVQPHLGHHGYNQKEDKMMNFYQDGPSDQGDYSLPSNSCASSSQLDTSVNCGATTIADNGASPSNTVTIPAAVDVERKPIPTNVLFSASMSAIQDVAAIISNAETKNLGMCAPDVVNENLMNVAQAAVQAQAIVNHTQQLAAAVVAQQVVSNMAPVMPTVNPLDPLLAPAFIAPPMPTPINVPITTPIAGALSTPLPPPIVPPGHSSINPVIPIIPKEMPVSVSLLNQLEQTPAEMVTVPKDMLMKLIQKNSRSTCTCSCMCGRYPPGSCIVDEVTKDLLNGGSSNSSNATDRDETRLETTEDMQMNGLLPGDCNSSIQWLNQQSSAQAFVDPITHSMTAEEAQTQRERRDSIFGSFSAADQGTVTQPKSVQEETIWEHTVAENESRELSDEEIEKMEELTEISNQWISMRLDSMPILDLFSKKNVEKIVNGLKLLSSFRFLPQVDKRSVVKRGLFNYCVVKWMQHKESMSIDGLSDAARRDFMNIIRREEFNYRVQPGAFNTLAISVLFHSISDNLISTDVYMEHLVFKKLLDKNLPIKVSSDTVYNNYYPYIIKAAKHLEKATKGLSDELVAHAVS
The following text describes a protein:
Function:
In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7; Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter. May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration. Plays a role in the vascular response to injury.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MSRQACPVLGASLFLSLAPQSLHGPLEPGAGTPGSGPEAGRAPLPLPRGPGGSRPGGGGLQEMPCIQTQHGTAAPSPGPCECFPAEPLSPELSKIMELAGPDTPGAPTVLPSFSTFMESYSGEFDTFLYQLPAPPQPSSSSSSSSSSSSSSSPAATSFKFEDFQVFGCYPGPFGAPSDEALSSSGSDYYGSPCSAPSPSTPVFPGPQLSAWDSALGPYPSGQTFDGPRAWTEPLPKAGGPPPPPTFFAFGGPPSPGPLKLAAGGLRRVEGEGYGPPPAGFPALPLGPGSPPPAPLLDGALVPAKGRGGGGGCGGGGGAEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKATPDAPVSLITALVRAHVDSVPSATRLDYSKFQASGPGQLGKEDPGDVRLFYDLLSGSLDVIRSWAQRIQGFADLPVPDQDLLLESAFLELFILRLAYRSKPGEGKLIFCTGLVLHRLQCVRGFGDWIDAILAFSAGLHRLGVDVPAFACLSALVIITGEGGGGPGGWGWGPGWGRAGRSDPPPPPPRSGPADRHGLREPRRVEELQGRIAGCLKEHVAATTGEAQRPGCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
VRAAPRSVTNTDHAQQAPHDNHHHPQDGKSMSFLFRFHDLIGGIHVPIDDGVDKLNRKYTLVVFLFLALPIFTRQYIGDPIECFTPTYFTDAQARFVNSYCWTASTYYLVSETPPAGGAERLRRVHVSYYQWAPLILLVQGCCFHLPFVLWGACAHSAGVKLRRLLKRASDIASLPPGCQQREALLSEFVDQFHTLVAGSAGCCTDPACGLPLACRCVGGPTRYLCLLYLLVKSMYVLNVGLQFLLLTAFLGRGFLRHGLELARRIMADGDWWNSPRFPLQTLCQVRAALQGGLRTYLCRCVLPINVFNEKIFSVVWFYLALLLPLNLASLLLWLWRCFRCNRFAFVRLCLWRTRMVSLGELSRVSRKIAVNYLGWDGVFVLRLIENNHGSAMATIILGRMYDFYANQ
The following text describes a protein:
Function:
Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Sequence:
MIRQIFGNLSCHVNDNKLIKIPNLNYTDSTAMSPTITCGILTVSDSCYKKEKEDTSGKELERAFRRAFPSFKVTHKDIIPDDRDKIINTLNKWVEDQCNIVLTTGGTGFSPRDVTPEATRAVIEKEAPGIAYAMITKSLAITPMAMLSRAVAGIKAQSLIVNLPGSAKGAVECFSFIQECIPHALALITDNKTEVTKKHREVQKRVSFVDGCGPSKVITDNVAERPRESTYAMLEVDEAFELVLKESEIRVETERLAVENALFRVLAEDVLAYDDVPPFDASVKDGYAVLASDGEGPRRVRTALGAGDAPHTSPLQPGEAIRIGTGAPIPPGADAVVQVEDTSVLRKSKGEEIEINVNKAPVKGQDIRRMGCDVAKNTVVLMNGERLKAPHVGVLAAVGKSTVTVYKPVSVGIFTTGNELKEHYEELRPGQIRDSNRLALINLLKECHYECDDYGIIRDDPDTIKKAIATALTINDILITTGGVSMGEFDFIKRVLIEDFNATVHFGRVNMKPGKPTTFATLSHEGAKKIVFGLPGNPVSASVTCLLFVIPLLRHLEGANVWQWPTIPYVVSVKKQSTDARPEYVRAVVSYLHGKIVAEPNGGQISSRLNSLVGANGLILMPPSMIPTREYLSHIILIGNLQT
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDIKRIILYVIVALLAIALFNAWQRDYPPTPKPTPTVEQPTANGDHPTAYTPPAFTPGAAEKTKKAGTIAFTSKVPEARLITVRTDVLDVEIDTQGGNIVSAKLPKYPVSLEEKQTPVQILSGEPNELYIAQSGLTNGNGQPTTVQFESEKKQYVLENGQNQLIVQLTGRAPDGLLVTKTYTFHRDDYAIHLAYQVKNNTSKPWQGSLYTQITRRQPPTEHHHFYVRSYNGASMGSPQTPYEKLSYESLDKQNIDRTSQSGWIAMQQHYFLSAWVPGNPELTYHYYSHVIPASDEPNVYVVGFVSPQMNVAAGSEAATHATLYVGPEIAKRLKGLAPGLERTIDYGWLWPISMLLFWILSAVHAVVKNWGWSIIITTILIKIVFYWFSAKSFRSMARMREMQPRIQALKERHGDDRQALSRATMELYRKEKINPLGGCLPMLIQVPVFIAFYYVIIESVQLRQAPFIFWIHDLSVKDPYYILPIIMGLSMLAQQWVSPTSPDPTQQKMMWILPVIFTVFFINFPAGLVLYWITNNVVQTLQQWYVNKTYESHKAKLKARRARKRKR
The following text describes a protein:
Function:
Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded.
Subcellular Localization:
Lysosome.
Sequence:
MGRFAAALVGSLFWLGLLLCGLGSLASAEPRAPPNRIAIVGAGIGGTSSAYYLRKKFGKDVKIDVFEREEVGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSSVPASGGLVGVYNGKSLVFEESSWFVINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMHAIGGDDYVRLLNQTLRENLKKAGFSETFLNEMIAPVMKVNYGQSTDINAFVGAVSLTAADSNLWAVEGGNKIVCSGLLQASSSNLISGSVMSIEEKTRTKQTGNPTKMYEVVYKTGSETHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTFIKGELNSTLFSSRPKDQFGLSAILVTDDSDMFINSLSIVASVRQKEGPPPAVDGMHVWKTFSRDILTKEQISKLFLSYDYAVRKPWLSYPHYEPPQKCPSIILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQDDLYERLKTEL
The following text describes a protein:
Function:
Member of the two-component regulatory system YesM/YesN. Probably activates YesN by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVYDEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMKQELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRNLWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMIADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVIPFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIEAGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPHFLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTIQRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAKGCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRIVITIPCRNEVV
The following text describes a protein:
Function:
Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
Sequence:
MNEQGLSEKEIFSYLENAKSEDTDYYRVLSSMCTHPHKIAVEANRLFIEANLGDLGLFAGASRLEQEVVGMLGELLHAPSIDVPFGGSCESSACGYLTTGGTESNIQAVRGMKNLVTTGKKELKGAPNIVIPESAHFSFDKVADMMGIEVRRASLDSEFRVDMASIESLIDANTIGLIGIAGNTEFGQIDPIDKLSEIALENELFLHIDAAFGGFVIPFLEKPQPFDFKLPGVTSIAVDPHKMGLSTIPSGALLFRSASFLDSLKVNTPYLTTKAQFTLTGTRSGASAAATCAVMKYLGNEGYRKNVQYCMQLTEKLVIEARKIGFEPLLEPVMNVVALKVPNPDFVREQMLERFGWNVSITRTPRALRLVLMPHNTLEDIEIFVQDLKEVTVEI
The following text describes a protein:
Function:
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes and for localization of sor-1. Binds RNA.
Subcellular Localization:
Nucleus. Note=Forms subnuclear bodies.
Domain:
The RNA-binding region is essential for the localization to subnuclear bodies and its function; The SAM-like domain, although only slightly related to the SAM domain, apparently displays a similar function. It is essential for homodimerization, the interaction with ubc-9, and the formation of subnuclear bodies.
Sequence:
MSSNLTSNEMSSTSAIVEPPEAVKGNERDKSTRRSTSQVVRPEKHEVENALEDQCSSSSLPKEAQYYAKLDKKLEGKDPRSQFYEAVRLSADIFAHKFEKAVCSRQTFEPTNSIIKVLNTAEEEMLHEKVVPLPVSSKLQYYLNRGRYDTIFDRDEQLQRTADPMADEPDHVEKRVTSILEQASREMEEGEVEPVFYDGSDEDQELPIDLGAMRNLQRTNKFAARSSRMAARRGGRPGYRGAFRGAARGAPSRRPAPAAEVAPETPVAAPMAPAAPAAPATPEAAPAAEVMDTSIATEMPQESAVDLSNVSAATEMDTSKEGEASRPTSEKKKKIRTTEMDRLMSMDLGPKDGGRVGELGHMWPESRRRPAAPLPETPAAQPRKSLPRRAAEKKKPEDSDAAEEQEVEMEVDNDASTSTPRNARGGRGGGNRRGSRRGQKRTSGGSGKLVEPKKEPVDEPAEKIPKRSEAAPEVPATATTKEAPPSTSSSPPDAPATPATPASSDSRDSPRKIRAMIFSLTGSPPESETPPVLQQEQVISTAAPTAGRHPNIIQQVPHINRIPPQPLRRLTAPQAPPASQPEEPPVQQTVPVVKVELASAPAPIVRDPQSTEPVPPAMPTLVENNHEATLILPPNKTSDYTRWNAQDLINWVRLLITNNVDSTIAIMVREEFDGETLACLVLDDDFRKEVPIPYGHYKKMKIYGTEVLNHYRTEKYQADLRKFHEELAAWKAQQR