lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b.
Subcellular Localization:
Nucleus.
Sequence:
MTEVDDGAELLFFDTFSHEDITDINLDLVQFPKPVFITQVRIIPLGARVQADFPGGVRLGATNPSKFDLEFFVNDLGMPGASAFENLGLLRYNQNDCIHLDCSREKIPTDGLVLRGWYSTITLAVYGILTNSVTQPIASPTLPCEPAGPEMCNLSTEAHNVLLQEEVLKDDWAEPIPTELLVPHKAVVVSDYEHDDIEYGLSREHQHYHQHVDEEQREMRRLRRSTHSTDRSPPPPPMRTHTHSESNEREYIRCSRDKGSRDWSRSPEYSSHRSRRKRSDRSRSDADEHKWPRTPPASIDSPIRPRSPDAMDYDDDDSRSHYKMQASRGYRHSSESLHRDRDDEERSGTPQEQFEPILSDDEIIGDDEEDEAEDVAAAAEYERELEFAAAVAPPAIDAFEPWQRPLLVYEGDLAAHLNKELETLRLLFKKLSLQTRCESVTAFSDEHGLSADEREQFVYLGEQLNNQLGYLSQHYKRRNFVLQQFFSHDDAHLRQAANVLQVALSFQAACMQPQPAFKIRHIKLGARMAELLGSNEQLFGHLLQEQDFDLFEAVLSLYKEPYMALSIKLQLLKAVYAMLDTRLGVQNFLSPKTNGYQMVMDFLKTAKLTRTKYALQAIIKKLHLYEALASVQQCCRQIFLDTDASVPETTPDPNRLDVCQKIEFAFQMLMDALTDSQLSYQQPRRFLPVSKKFEVLTDPTAQRSFGNALQSYFVQHSLAEALLVILSNPKEVPASTFLCTLDLMHTLLRSHVGIDYFVDDAFPVTQMIVSILLGLEEVPSQPRVVEAKPEGKEDKPMDDSVEQKPDEGKAAGIRAAEEPKMAPPPVVRKPILRPVLPRLARLGIELSYKVQTRYHLDAITFTAACPEYDTIKIATHMHSIYSQTCDPSGRQHTIEVLGLNNNLKIFMDLIKKEQRLQTQRQLLSSPGTKYKSPVLSYAVDMVDACVRYCEQLDYLIEHGGVILELAKNHETFEPSVSAVLQEMYVYMKPLEAINVFVYDDIMPLVEVIGRSLDYLTTFPGDLIMALRILRFLAISKPRQKSHGTEELKHRFVALQLYAADGVQLLLQIMERLCTHFEQPGIHAPALMTIQGVHCCQIMLPTLQILRELLSYAILCRDGTYKDLTAIDHLVKVYYLLYYYPSRCQAGAEVEQCKLEVVKSLLAYTQPHEQDAESLHKSLWTLMVREVLKNIDGPAHFIPGLKLLAELLPLPLPMPQPLCDQLKQQHKQRLIIERKLWSAHLHPQSGQIAKLVEALAPSSFPQLAELLQRVCMQLSDLAPNMTLLIAKTITELLCTEYQTSNCIPTTNLERLLRFSTRLCAFAPLKSSMLSILSGKFWELFQSLLALNEFNEVVTNCQEAVHRILDSFLDSGISLISHKSTAQPALNLSAALPPKELIPRIIDAVFSNLTSVEVTHGISILAVRNLVILTEHDFTFYHLAQLLKQKLTEFQAWMERVILHNETVEYHANIESLILLLRSLTQIEPPPPMCAMPNRTLKLGAMELAQLVEFQDIDMARPPVLARILRVLEKYKLLANEAALCDLKQLIVLHASRQEAMGSASMETPAVETENDGANPAASCSTSSSGGSLNVEPFLPQAEGIVTQYDARPIFTRYCATAENPQLTARYWLEPLPIELIEDMNEPLYERIACDLTDLANVCLNPDLATSGESKRTLNLSGSPQSNREMTPTAPCFRTRRVEVEPATGRPEKKMFLSSVRGRGFARPPPSRGDLFRSRPPNTSRPPSLHVDDFLALETCGAQPTGPTGYNKIPSMLRGSRVGRNRGSRISAAAAFRQKKMMRIGSPSSWTESGGGSYRSTSESHFGGSDSHYSSPHYSGRSRGRGLRSRPPYLR
The following text describes a protein:
Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAAPMIHALRPVPCLFRPLYRRISHSAGFLEAAGRRGLFKDVFPAESGPSQLSELLRSGPQTVYCGFDPTADSLHIGNLLTVLGLVHFHRAGHNIIAVIGGATGLLGDPSGRMNEREALSQEKITENIRGIRRCLERLFSNCETLVPGARPGGTVRVLNNEQWYRQRGAAEFLGSVGRHFRMGTMMSRHSVQSRLSSPEGMSLAEFVYQVFQSYDFYQLNQTHDCRIQLGGTDQLGNIMSGHDFIHRITGEEVFGITLPLITNSAGDKLGKSAGNAIWLSRDKTSPFELYQFFVRQPDGIVERFLKLFTFIPLPEIEQVMEQHGKEPEKRLPHKRLAAEVTKIVHGKEGLESAKRCTQALYNSSLEALEKMSDQELQELFREAPFAEVLLEPGTRVMDLCLKVSAIPEGARGYEMISSGGVSINHKKVTNPDEVLLLGHHILHNGLSLLRVGKKNFYIVKWLHL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MAPITPIAAVYRVCNRHVAPLSSPTIFIQTVLRQTIFGRPITIGRIKPTNASSISELQSGNQSRSNVDGSSWSQLTTKQKVVQSGQNIGYGGVIVFGVGILGYAIWTTVSDLSKTSQAWKIYDASVEHVLDSVQVQQALGIPITPQPGPGPASSRGSKTLRYGESVSSETHERLLNLKYYVYGLRQSGVVDVQAVWDPQHKYQTEQNEALSFANGFGLNLFGLSSPWSLQVIVVNASGRRIVVMDRRLHSNGGSSTNRGWMFSLFPRRIIAQSQTQRSI
The following text describes a protein:
Function:
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the tom40 translocation pore.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MVAVGKTSAIAAGVCGALLLGYCIYFDRKRRSDPNFKNRLREKRRKQKIAKERAGQSRLPDLKDAEAVQKFFLEEIQLGEELLAQGDFEKGVDHLTNAIAICGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIGNAQNLSEDDVE
The following text describes a protein:
Function:
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis. Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSLWLEASMPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGVALGIGLESAEPTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MAAKGAHITPNIEVKPSLFEVLAADSLNITFYPAIKRVVDFLATAKPAVFGGLVRYYDEFYLVFNGLVQGYYIKQYGGSLAEVFYGLTRQSLRSKSFSRKDRNRSFVVLVLVPYAVRKLEKACARWKEDYENAKHVPAHRKQLFRLLPYLQACYEGAKLIHYVSYLANVTKTHSPSLRVLELGLTYLSEEEESWSFKDVLQGKVRVATMISAALLRWLELSAFFLQFIEWWQTEANIGDLSKLPIPDAPDQDSNTNKYANVCPICLQKHIIPTAVSVSGYVYCYRCIATHLQRESRCPITKYPATINDLIGIYTGDDD
The following text describes a protein:
Function:
Master transcriptional regulator that mediates the response to amino acid starvation (By similarity). Binds variations of the DNA sequence 5'-ATGA[CG]TCAT-3' (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The leucine-zipper is atypical but could still mediate protein-protein interaction.
Sequence:
MSTPNIAQDFPELFDLQSNRFGDDLSSPESNMLSPQINTSFFSPMGEVAPPGTVSPKDLFFDASAPPSTTFTDLSTPPLDTPGFFSQNTSPMINTEMDLNAVPEEWESLFPQDGFSLDLDSAALELAASLQQPKATGPPPTPVIRASASPAPSASPAPSRQGTKHSTVAGVNARQRKPLPPIKFDSADPAAMKRARNTEAARKSRARKLERQGEMERRIEELERMLEESKQREEYWRSMAKTGTN
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
Sequence:
MHENQQPQTEAFELSAAEREAIEHEKHHYEDPRAASIEALKIVQKQRGWVPDGAIYAIADVLGIPASDVEGVATFYSQIFRQPVGRHVIRYCDSVVCHITGYQGIQAALEKNLNIKPGQTTFDGRFTLLPTCCLGNCDKGPNMMIDEDTHSHLTPEAIPELLERYK
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNRQLRTVKSCFSLQKTHQYRSFWIQSSLRALPPDVKQNKTEPIPFVPKPEEGSSNKSNSSKFRKRFLLLFLLGITGYSCSVVYCFKDPNFYDYFAEHTPFGKQVLYNVEQSWIGYKYLGGNRIKVDDSSPKLKQNSNNISKKQNSSRNDDTKVKKDTTIERPESLVVEIVDLPSEVTKDTAEESVWKDIGLDQETGLSVTAIPIITETLDHAHEQEIKDQSLRFESSLNEANELHGKLSKIQQEQEHLFEQRLREKVSEMESKLEALLIARDEKWQSAFESEKLRLQKLHEARLQQELFKLASVFESKLKNELTEQAITLEKLHLQSIKAQVEQERGSRLGRLQELRNSFQQLQELVRVVLHENGRVTRLVDVSNTLDDLNKDMRFHKLSEVRQHVNTLKEATKDDELAALASRVIEKIVDSGPILDKEELQTKFDTLSKEIYKTCFLTTESGFFGHLKSIILSQLPAAVFKSPDIVSVKKTLEDARSHLLKDDLDGSVRALLSLSQWPRALSRDWINACRRRMELQQAIEIIKASATLSSQLEDAQQA
The following text describes a protein:
Function:
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Sequence:
MTSPQNGTSLPTHPGLLGRGRRAGGAGSILRRLPGTAPPGLTQRAGLGLQAETAGAEPSQECRPLENQAEVSRVLSPRRVSASSGVTSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEQKSLPKQASDTGSKDAHNKKAVSRSAEQQPSEKSAEPKTKPQDTVSAGGESVAGVAATSGKPGDKQKEKKSLAPALPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKTEGITGPPPDSLKPMGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLSSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATARSESELIDELSEDFDPSKYKEKPSKPTEKTEESKAAAPAPVAEAVSRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTHTGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDKGQDKPVKPPTKKSEESKKSADDQDPIDALSGDLDSCPSTTETSQNTAKDKRKKTASSSKAPKNGGKAKDSAKTTEETSKPKDDERNTS
The following text describes a protein:
Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
FNGWYNNLANPSSGATETALTRRLKSHYEDGVYAPSGSGRPNPRTLSVEIASGPSGLHSYDNKTTLFVYFGQHIIKEIVENSRQGCPPEYFWIPVPEGDEIFDPRGDGNIRLPYHRSPYIASNTGYTPNHPRDQLNEVTSLLDGDSIYGSTKAWSGELRLRKGELRSADDDGKLPMRNTIGLPLQNPVVPVYHEMRNAKRLFATGSRTGNENPFLLTIGVTWFRHHNWLARQLRDNNPDWSDEHVFMESRTRNIATYQKVFFYEWLPILLGSCPSFPIIPFFKWTGYHASVPVGVSNVFQSAAMNYLDTMVPPGGFIPKTFDSSKHGCNSSNSDEMDKWRTCNTYWNSDELFENATPFNIVYGMMGQMAESEDHIISEDLRNSFHGSMEFSRTDKVATIIQRGRDHGLPDYNTAREDLGLKKKETIRDINPDLFKKDEKLLERLHSLHGGSPSNMDIYVGGMLESKDGRPGELFRSIILEQMVRLRDGDRFWFENLNNGLFTVDQVNGIFNVTFLDVLLRTYPELNLAGNTAFNPFIWSEESNKHICRQPYQMTGDNMTSCTTMQRQDDFNHNQISFLAIFCGVVFFAIDFLLLACVIFMIYVGSWKEDKRNKEKTKTTSTYSEQDAFTAKEILGRKRHERKDVQVVLGPERDIQVITQENNTTHITHITESEEVVIMYTDSGKRKKMLLRCAKRTYDLILAFTGSSERDIFLTKLRLFFKQNDILWKERAIHEKHFFEEANTKDERDTELSNFYQAVIAQSMRMEFGIQISSFPENLVDIKLSQEEFASLLQMKSSSLFVQHIFTTADEDQDGFISFHDFRKIIVLFVKGSPNEKLRLLFDMFDLNQNGSLTKQQFKEMCVCTADTYQSTVDQNVLENVLSKVVPLKNDEEIQYLKFDDFKKLMDLPEMDEAMLNLTAPGRVRITGSQMFIFIGKNKKSLAKSSKNERPNRGNFIQTAEGQGIHIHSSRSPNVSTVENVMPDVYFQNSSKFRLAYRAIRRLFECYALHIFWTSLYIWITIGVFLWAFNSVRSNKAAGLGVIAGNALPLARASAAALMFNISTLLLTMCKNILTFLRETQLHLYIPFDAAVAFHKLVAWMALFFTALHIIAHGINFYSIQTQTPSDLLCLFRDLWFPSDYQPTFVFWCLQTLTGNTGVLLTIIFIVMYVFSLDYPRQVMFNWFQWIHFFGYISVYFFTVLHGSGMLIQIPSFYYYFLVPAILYTFDKLYSVYRKKLQLPVIKAEILPSDVVYLEFVRPSDFYYKAGQWVRIACVGLSKWEYHPFTLSSSPDEETLQLHIRAVGPWTRNIRNIYKEGEPYPKLYVDGPFGEGHQDWYKYEVAVLVGGGIGVTPFASILKDLVNKSTVGVGIPCKSVYFLWVARDQRQFEWLLDIIEETEKNDALGILSTHIFITEIPNKFDLRTTMLYVCEQHFKKVSEKSMFTGLNAVTHFGRPNFPDFLKTLSWKHSEVKKIGVFSCGPPSMTESVESACLKANKHKGPMYAHHFENF
The following text describes a protein:
Function:
Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection, axon. Note=Detected at nodes of Ranvier on the sciatic nerve.
Sequence:
MGTLLAFVVGAALVSSAWGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAPKKNKQREKQEQSRASSSARAHQSLLASAGSAAASPAFIGFASFAQPAPHVLQATPKGSAFYTKPAVQSIYDGSDHEIALALKMLAKKGAVTKSKALLTFLQDVLPPRAPAELRPMLGHFTQLYTFEMRDQNDRKVRQLLNEVLAVLADKMRPRAFVPHLQRLLPYWYLAMHDVNADVAVLAKKAFVTLFPEVEMQKTVLEEHVPAMMEEFQSFFTKTPDTFEGIPLLADEKEERYERCVSAAVLSIDAVIKFFVENELTDKLSDDDASCNVTTLVSSDKFLRLATASSKHPNFSRDGVRRAMYLAIVTLCTNAKSIVAAREEAFGKVVLGVLGDKSPSNHEAMWNAVLTFLQTFPSVWHSSASFPKFVVSAVYPRLFAQIRHGFYGSGRSSFPTLLPFLSMVPLSVAVDPVKGQSVLYTGVLEQCWKFIESKDARFAESPAITAFFECITGFFSIFLKESGNAAWLRVQDTAPFEANYVNQFEKVFVSSLTSTLSSPEFPEGGVVLCASSLLKMSSRLHSFSVEADVVNTLKDAFLEKLHTWTRQAIGTMIAKTSFLPSRVNTLISAGVADAKDRCEDREAAQWLSTSKEIYGQSLDQIDTLMMEPAFTPVKNASIVQLLEAINGVCKILPLDLLLLNGVDTPVETHFDDHYRPVLHALAEWKKSPNSKSVAKTMRVALELTRPFFLIAREKKQFLLQLFQDCGVQFGDMAEASEIIQYGLQFPVTEQGNKLWLSCGSWQSHYECGVSVSDQSNATLEALQAIWQGKLLDEFLMISLKGRLDDLDGSAFATLLKACLGGLSNAPVVSSDAVVILCHFVIQNGADSSDAVVVQMLTHLCELFFKLNGGLPAELESVESQLYKLLFHLSARGSYRTEASELWARTVRYSLKKWTSTRTEVFVNDLAEHVNAFPFADLPPGTVSFNTKQFAAYVKSYVQLGTDQAFFSVSQLVEKLDAVNVRCIADADDSQLKLFYSRVLSGLGEVCEDEQSVHVLQEYFISLASEDEQKAVDLVMKLVDLDVTHALSWVVFHSDDHIQRRLDLVEIMESYLTLEHLFEALRSSSTVIDKTLALALQTCQDKCTHGSAQYRDLVFLSKNQSAVVASENADLLTQEQHKKLDELIVAVLSTFSSVAVRVAFIQTLVDRKGDWKADAAQTVAVSLFSEMYPAKEASDEIISVLQDFFSLCARDAIAEPATGFFEYLRLVARAVKVGALSNASEQGIIDLSTQESVMTRIQKMLAPSSPTVVGVKEWIAATEYVSALSAYVQVGSPEFRDAWENVARLVVTHAIAGKSEIAKISALKVQKRSSTLGDRRIMKGDEEKIVLSYSSELAAARLVLMNLVSAIYESNPDALQELAAHYREALLSTVLCALSESAELKASIVTTYVALVSPSQCFQLTYLWFSIEKVLASALPALRSTLTSIHDIDHVNRLVLESFGGIETLASLFNGKRYPLQPVLRVLLYILASYSGALRLHNYDASAIDVNAEDEAATESALAKVLIPKALRSALRAVFADKNGESGAANIRMRSRKQKVQEREDITGKLLLWDLFLQLFPASGGENNGESGGASSTLVASSLSSYVTRHGMLTNFLNFCSALLSQESQSASKAAVSDLQDTALFDATDLSKKEDDETWSLHKTRVFQLGTRVFFRTVVRLPAMVRSWWNDDCSRGTRSWAAKYFEDHITPSVLAAELQLIQKAGENSSAAGESWDDEEMTVKGSRVSREITTTYIKDECALEMVVRVPSSYPLRCVEVECTKRIGISEDRWRRWVLQIIRVTSSRDGSLLDAVLLWKHNVDKEFEGVEPCPICYSILNPKNMGLPSLPCKTCNNKYHNSCLYKWFNQSGKNKCPICQQPFC
The following text describes a protein:
Function:
Necessary for the biogenesis of 40S ribosome subunits by regulating pre-rRNA processing. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Necessary for endoreplication driven by Myc.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKGKKPYIDRKKAVTFHLVHRSQHDPLVTDENAPQRVLLEAAARQQKPKDPEPPTDPAQRQEELKKFGIHFDDDYDYMQHLKKRENDVVWEFMENPNQARKQKVQDSEKPGPAPKLMLPSSVFASEFEESEGMLNKAAPQTLRLDWDPDVVAALDSDCENEELEDDFVIQAMAEGDSDDEEWDDEDGEEQSDMDFDSDDLNEDENEDELMDRLAPLMRERRFDDEEVKSRFTEYSMSSSVIRRNEQLSLLDDRFEKFYATYDDPELGDLALEDIEGNWHQKHPVVMQCFQEFKKKDKGIEYNKEWDRERIEKYRNVVEGEEDPTEELVEYEVDDPKQKKWDCESILSTYSNIYNHPKVIDEPRRSRRSSASTNPAPIQIDPKTGLPTNVLRGGVDGQLTAKALANLADESPAATGPKSLCAKSVLSTLSVLSIRPKDETHEEKKERKRLLKDYRNERRIEKKANTEAFKEEKKRQTHVKINQRTNQQGASIV
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MFLSLDILQIFHIFKMTPWIKQLLFTCLLCIGQTQAEFFTSIGQMTDLIYAEKDLVQSLKAYIQEEESKLIKIKSWAEKMESLTTKSTSDPEGYLSHPVNAYKLVKRLNTEWLELENLVLEDATKGFIANLTVQRQFFPNEEDETGAAKALMRLQDTYKLDPETISKGEFPGTKYRSLLTVDDCFGMGKTAYNDGDYYHTVLWMEQALKQHDRGEEATITKATILDYLSYAIFQLGDIHRAMELTRRLISLDPSHERAGSNMQYFEKLLENEQNEKALDDAPNATEPSTYNGIYERPPDYLPEREIYEALCRGEGVKMTPRRQKRLFCRYHNGNQNPHLLIAPFKEEDEWDSPHIVRYYNVLSDEEIEKIKELAKPKLARATVRDPKTGVLTVANYRVSKSSWLEEEDDLVVAKVNQRMEHITGLTVKTAELLQVANYGMGGQYEPHFDFSRRPFDSTLKTEGNRLATFLNYMSDVEAGGATVFPDFGAAIWPKKGTAVFWYNLFRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGNEFLRPCGTTEVD
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MDPVLIHAQVQLWSAKAGMSKSRNAFIETFIGKREVKLILYFSTGKIKALQLYNNIKSVVLRTYGEDQNYLHLTFKNNDFLFVEKLTTMDARRLKRFLDKIYQSNLRAARRSGERPGDPSTSAQELSSSPPEGHLKASSACFESAKESEMCLFRQLPLLPPSSASLNAVGLLESQFMKRKRFFLGAEKEKQNLKGSTREFETNLVVSISNEKGKERGVRAVEISKAGFGFPFETNYPEEGSVNVRDLNDLITKLFSPLLFETHYIENGLDWHEYMETFLLDPEKSWQGLPNVGNTCYINVVLQSLCSIPLFVNDLFNQGFPWIKPPKDDFNMRLMQLLVLKDIYNARTRQKLLIGITKALPIFGEVFAADRQNDAHEFLSLCLVQLKETVQRVNMMWQSENESGDYYLLREIFANYTSINRTPVCPVTNNFEFELLSSIFCKACGLTVFKREPSRYLSINIPQGMKDQNMSIQSSLDLFFRAEELEHRCERCLYNKSVALHKFGRLPRVIIVHLKRYSFSESRIMNKDEQHIVISKYLRLSCHCNKNTKPPQPLLPNEHVKNLDLLRPLEELGSEILKLSSNSGRTSRSKVFPTVNIRSDKELEVQNGKRVSEVSSGSAQQEDPGKGANVVRSELTNETETIKHEKEYVLSDLDSGSISEERSQKCQEAEKCNKEALPQSCPKPSSQEQTENLGKPAVSHTQNGSLSSQGSSDSSKSPGCNDVFDKAKPTSKVEPQKLNQKEDNIYRLVSIINHIGNSPNGGHYINDAFDFRKQSWFTYSDLQVTGIQEDLVYKARLSTGYVFFYMHNDIFEELLAKEAWSTSTSKG
The following text describes a protein:
Function:
Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation.
Subcellular Localization:
Rough endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MKKLRVLFLCSVLALLCWHSCHDVYCSEEVSSGPGLPAQDDGSYTMQEPGAGEKVEEERATHTQSSYDVGLETERAALKETSLHSQETPHEEKHKQTVNLEEVLEEPQIQHDSALPELEQQQQQEQHPEGQSSQHPDQQDSAQPPTFAQPETAPPLSQPDPEVPQATATEDQAAQPSTDETPPHPDPHAEEDASAPADELQNSPESTSPTSVTSSESLSSGLDVPRPDAAVENSSASQCEVGSVPPFSQQLGTTLTSVVEEQVETQAENQSTVLEQSTETSTDPADSLDPSELDLTETGQTDRIPPPTESQQVADHEGATDPPVPSKEDIPTFDEWKKKVMEVEEKKSQSLHTSSNGSPHPVKKVQKNFKNNYASVECGAKILSANNEAKSTSAILMENMDLYMLNPCSTKIWFVIELCEPIQVKQLDIANFELFSSTPRDFLVSISDRYPTNKWIKLGTFHARDERTVQSFPLDEQLYAKYVKMFIRYIKVELLSHFGSEHFCPLSLIRVFGTSMVEEYDEIADSQYTSERAEYLDEDYDYPPGYLPSEDKASKNLLGSATNAILNMVNNIAANVLGGKPELEDGAELEGNVSSGTENVTQASTETTLTPDPTPTEQPHTLDVLELDPTFVKEDMEAPIPEAPSQAPTVAPAEESRIVILIEEDEESTQPTVTLLEEEGEEERRLEELWESESTTYCGHLSTLSCLASLHEHFYCYCSAALALQRQRKDRRHKAQHTQAHTKTQTTSQQTLTDPTPSQEPPAPSEKLSEAERPSQTQSERISPTETAAAPSESSNWESSSTELELPPETILLEPSRTSTLPPHSFSETPTQNIPESLPTGEPVDQRPQYLVDIPETHAPGSVCSSTSSVPSPSAVSSTPLSSTTEPHSLETDPPKLELPVPTKEQTAQPLPTHTRPAEIPPPTEIPILIPEASENGKVSLVEDQHHNAVVSQPELSEAPHEDTVDDILLPHRTAGEFYAEQQQTAEMGHSNGNGNGNQVHGSNQKESVFMRLNNRIKALEMNMSLSSRYLEELSQRYRKQMEEMQRAFNKTIIKLQNTSRIAEEQDQKQTESIQMLQSQLENATRIMLNLSATVAQLQREVSDRQIYLVLSLILCLMLGLLLCTQCCRSSTNHNTSPTIPMSNNYPSPKRCFSSYDDMSLKRRVSCPLVRSKSFQLPTSEVGPDDLYIVEPLRFSPEKKKKRCKTKAGERVETLRASATAPNGLLKLNGESSPPLQFLPSTCNGYTSTCSSRDCASEGSSESSVSTLSEESFGSAPSVNGHELVLYNGEPPPACPPAKSRTEKKRRRSRQGEQDSMLSASLPLPALEELIKGKTELGVASFGRTAVTGRV
The following text describes a protein:
Function:
Likely functions in the release of soluble HxuA from the cell; Probable member of a two partner secretion pathway (TPS) in which it mediates the secretion of HuxA.
Subcellular Localization:
Cell outer membrane.
Domain:
Probably a beta-barrel protein.
Sequence:
MKMRPRYSVIASAVSLGFVLSKSVMALDRPDTGSLNRELEQRQIQSEAKPSGELFNQTANSPYTAQYKQGLKFPLKQVQILDRNNQEVVTDELAHILKNYVGKEVSLSDLSNLANEISEFYRHNNYLVAKAILPPQEIEQGTVKILLLKGNVGEIRLQNHSALSNKFVSRLSNTTVNASEFILKDELEKFALTINDVPGVNAGLQLSAGKKVGEANLLIKINDAKRFSSYVSVDNQGNKYTGRYRLAAGTKVSNLNGWGDELKLDLMSSNQANLKNARIDYSSLIDGYSTRFGVTANYLDYKLGGNFKSLQSQGHSHTLGAYLLHPTIRTPNFRLSTKVSFNHQNLTDKQQAVYVKQKRKINSLTAGIDGSWNLIKDGTTYFSLSTLFGNLANQTSEKKQYTKEDFQPQSHFTVYNYRLSHEQILPKSFAFNIGINGQFADKTLESSQKMLLGGLSGVRGHQAGAASVDEGHLIQTEFKHYLPVFSQSVLVSSLFYDYGLGKYYKNSQFLEKGVKNSVKLQSVGAGLSLSDAGSYAINVSVAKPLDNNINNADKHQFWLSMIKTF
The following text describes a protein:
Function:
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
Sequence:
MMNFTLLTYLADCQPKVRSELEKFSKNLEEDIQQLREIGLDILVDGQDYRLVPMLPLLNPQQISTALFPYSIHYQPIISSTNEWILQNILSLKKGDLCVAEYQTAGRGRRGRQWLSPFAGQIMFSFYWAFDPKKSIEGLSLVIGLAIAEVLNVQVKWPNDILFDERKLGGILVEIANHKNGMLNLVIGIGINVSLSKQTEISQPYAEVCEIDPDVERQTLLPKLIQHLYTRLNIFEQNGIDEEFQQAWQSYNAFSNSEINVLTEQGVISGIEQGIDERGYLKVLCGNKIQMFNGGEVSLRKK
The following text describes a protein:
Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
MSSSRQICVFPSPAELALSLSQLLVHESQGTCSFRLALSGGSLVQLLSRELPKTAGLNTAGWKVAFCDERLVPFSDPESTYGEYKRQLVPHGLLSESQFVTIDPALPVEEAAVDYTKKLRELFPDDGLPAFDLLILGIGPDGHTASLFPGHPLLQVTDKVVAPISDSPKPPPQRITLTLPVINAAKTVVFVATGEGKATILKRILQEEESDPLPAARVSPVRGKLLWFVDEPAARELTCPVEKHSVL
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MTLIRLGPVHMGLRNIRPSQSFTKPSRSSPSRYLSSGSTPGFCSRRFYGSSHQQGSGPTGARLWAGPSPGRGSTGYTLLATALGLGALASGATVYALQTADLPDDPLAALAPDALRLKAAHVAQKAAPDLLRSYLTLLLCEIPGVATYGPLLLNHCISLRDNVPILGPATWSVVEWFVFHTFFSHYTGGESAEDCQPVMKALYEGEVGSLLNYSVEALEGAGKGSSESGLSRESVAAITRTVESLAGYESGAKGYAASSARMKPSAVAIKVSGLVDDPYLFKRASENLLANGLSPFRVNGSPFPIVNSHIPDPLSPADHLTLDGLMDSLRGVCQKAKAADIVIMIDAEYSWFQPALDRIATFLSAEFNKSKSEGPGSASYSPTVFNTFQALLRSTPERLAEYVDEGHKRDFSVGVKLVRGAYLVSETARWREARAAGRPGVPDHPPVWASKAETDGCFDNLASSLVQQLASNARRAQGLTSDPRQSRSSNSIEVAMMIAGHNPISAAKVLKQLRDEEGLAKNVDGQSIRLSDSLRGRLMFAQLYGMADNLTSTLTQILAPSDADNQKHPQPFVFKYLPFGPVDKVLPYLARRAEENSSILEVKDGESVLSLERKLIGKEIRKRIGSLFFLS
The following text describes a protein:
Function:
Nuclear serine protease which mediates apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MGFQNDMPFLPEKEAFADDWAETVNKVVPAVVVLQTTTCRAFDTELPSSGSATGFVVDKQRGIILTNRHVVNPGPVNAQAIFVSNEETPLRPIYRDPVHDFGFFSYDPGAIQFLNYEEIPLAPEAASVGLEIRVIGNDSSEKVSILSGILARLDRNAPAYEKDGYNDFNTFYLQAASGTKPGSSGSPVIDKQGRAVALNAGSSSSSSSAFYLPLERVVRALRLLQKCKDARANKWETVSIPRGTLQVTFCHKGFDETRRLGLRSETEQMVRNASLLGETGMLVVDSVVPGGPAYGQLEPGDMLVSVDGELTTRFLKLETLLDDNVDQKIGLQIERGGISLTVNLTVQDLHTITPNHFLEVSGAVIHPLSYQQARNFSIQCGLVYVAEPGYMLQRSGVPCHAIIKKFSGVEISQLEELISVFSKLSRGARVPLEYIRHNDRHRAKSVIVCIDRHEWYDAPKIYTRDDSSGLWIARPAIQPKFLPLSSCSSDAEQHPKIQSFSLSGESTLAKHMHQSNKQELTNGVARIEDSNGHISKEAHSGEEYDAKTKECQEQGHFSSKEIVAANCSSREIGEIKLKDPSTTEKTVLNGIETATSTASFAESLIEPALVTLEVDVPPSCLLDGVKSVASCGTGVIVHHSQCMGLVAIDKNTVEISACDVILSFAAFPIQIPGEVVFVHPVYNFALVGYDPSALGADGASMVHAAELLPEPALCRGDRVYLVGLSKNLRAQSRKSTVTNPCLALYVHQVDRPRYGATNMEVIELDSGFGSEFTGVLCDERGKVRAIWGSFSNQDYQFVRGIPIYMISQIVDSIVCGGNGPSLLINGVKRGMPLIRTLEVSLCPMLLSEARNFGLSNDWIQALDEKDPVRRQVLCVEGSYAGSKAENVLKQSDMLLAVNKESITCFRDIENACQALEECGGSDGKLKITVFRQGCEVDLLVGTDVRDGNGTTRAISWCGCLVQDSHPAVRTLGFLPDEGYGVFVTKWSLGSPADRYCLSALKWIVQVNGKPTSDLDAFANVVKELGPDECVRVKTVDLDGKPQVQTLKQDLHYWPTWELRFDPDTAMWRKNTINALDCSNG