lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MLRQLLLAALCLAGPPAPARACQLPSEWRPLSEGCRAELAETIVYARVLALHPEAPGLYNHLPWQYHAGQGGLFYSAEVEMLCDQAWGSMLEVPAGSRLNLTGLGYFSCHSHTVVQDYSYFFFLRMDENYNLLPHGVNFQDAIFPDTQENRRMFSSLFQFSNCSQGQQLATFSSDWEIQEDSRLMCSSVQKALFEEEDHVKKLQQKVATLEKRNRQLRERVKKVKRSLRQARKKGRHLELANQKLSEKLAAGALPHINARGPVRPPYLRG
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MASGWGISGHKGRCYDFWVDFSECMSRCREPKDCTLLREDYLECLHHSKEFQRRNRIYKEEQRKLRAAARNTKDGKEGVDKHHH
The following text describes a protein:
Function:
Possesses low disulfide reductase activity, but efficient protein disulfide isomerase activity. Does not possess deglutathionylation activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MARVVKIDSAESWNFYVSQAKNQNCPIVAHFTALWCIPSVFMNSFFEELAFNYKDALFLIVDVDEVKEVASQLEVKAMPTFLFLKDGNAMDKLVGANPDEIKKRVDGFVQSSRVVHIA
The following text describes a protein:
Function:
Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MAPPPPQTPTPVIPREAWEGCSVLLDINDGDRLAFFRLTTGATVKIGDKSCSLQPLLGRPFGSLFRVGPSGLVPCAATDASSQDDKARDGSACGQAQDETRDNRSLVDNNTAQTLSSEDIEAMKREGASGDAIVEALIANSSTFGNKTVFSQEKYKLKKQKKYAPKVLLRRPSSRSICETYFKKYPARIGFMRVDALSLLLSMANVGAYSDVLAVDMVGGLVVGAVAERLGGTGYVCSTYLGSAPSSIDIIRMYNLSSDMTSRIFQAPLGDLCSLQSAGDAPSVLSGSIQRDLVEPAAVPDESLQSSPAKPINTEVSDGNAQSMTVQPINMEVPEPATDHLNQDCKGSNGNSIAPKAPRAGKAPSPERMKYWGEHGFSSLIVAAPDHEVESVVADLLPLLSYSAPFAIYHQYLQPLATCMHSLQVSKMAIALQITEPWLREYQVLPSRTHPHMQMNAFGGYILSGIRIHKPDP
The following text describes a protein:
Function:
Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment. Controls zinc deposition in milk.
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MWRPQAWWSSVRSALQRSDQAPYLNDATGFDDEPALEGEEDLPRFNKLRVLVADEPVATNGLPVNVASDDESLLESSHSRDKPEPCDKCSSHREMRKQGKVKRKLVLAAVLYLLFMVGELVGGYVANSLAIMTDALHMLSDLSSIILTLLALCLSSKSPNKRFTFGFHRLEVLSAIVSVLLVYILTGFLVYEAIQRTIHMNYNINGDVMLITAAVGVAVNLIMGILLSQTGHPHSHSHGPTANSPSPHGHSHGSLAVRAAFVHALGDLAQSIGVLIAAYIIRFKPEYKIADPICTYIFSVLVLFTTIRIVWDTVLIILEGVPRQLNVDRIKDDLMKIDDVYSVKDLNVWSLTTGKSIAIIQLQLCPDASSKWEEVQNKARQVLLNTHGMYKCFIQIQSYRQEENTHCTDCSSA
The following text describes a protein:
Function:
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MADKSFDKVLKNRQCKLANKSSKPLLERQRRARINHSLNELKTLVLSSLYQNCPQAEQNCEKMEKAEILELTVNFLKVIQSRRNTVMPRPDLGKAHEFHHVKMEQMSPEQANARQHPIIRVYHKIALSTVLKGGVGGLKTTLKESLLIYGDLFEAMLSFLNFGIFQLLKS
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
Miscellaneous:
MISCELLANEOUS: In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6 protein in the FACT complex of fungi.
Subcellular Localization:
Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Sequence:
MVNTDFEKIYLNQSRAGGRMRIAESGLGWKASASSGSTSQPFLLPREEILIASWSRGSKGYELRVQTKNKGVVSLDGFDHDDFTQLKQELTRNFHINLEHREHSLRGWNWGKTDLARNELIFNVNNKPAFEIPYSDISNSNLTGKNEVALEFNLDNNKNGDEIVEMRFYVPGTIENETTIVKNETNGDVIEEAVVNETSAAQQFYEQLKDKADIGQVAGEAIVSFSDVLFLTPRGRYDIDMYPSSLRLRGKTYDYKIQYEQIERIFSLPKPDETHHLIVLQIDPPLRQGQTRYPFLVLQFVKDEETELELNVSDEDFEKKYKDRLKKTYDAPTNVVMSHCLRGLTERKLITPGAFQSRYLQAGVPCSVKASEGYLFPLDRCFLFVTKPTLYIPYSEISSVVMSRTGGGVSASRTFDLEVNVIGSNQPHVFSNIDREEQEFIESFCKEKGVKVKNEEKIAKARLAKALEQEANDDDDEDADMGSAGDEDEDEDVDFQSGSDSDVAEEFDSDAAPSSDDDEEMADSKETDDRPPKKKAKN
The following text describes a protein:
Function:
Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange. Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Recycling endosome membrane. Early endosome membrane; Multi-pass membrane protein. Note=Localization to the Golgi and plasma membrane is regulated by zinc.
Sequence:
MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MFHNFHILSLSSYAYNLFFASAGMLSSLVMFFKFGLYELFIFTLFSVLFISFAWGKDIAMEGLSGYHNFFVMDGFKFGVILFVFSEFMFFFCIFCTFFDAALVPVHELGETWSPFGMHLVNPFGVPLLNTIILLSSGVTVTWAHHSLLSNKSCTNSMILTCLLAAYFTGIQLMEYMEASFSIADGVFGSIFYLSTGFHGIHVLCGGLFLAFNFLRLLKNHFNYNHHLGLEFAILYWHFVDVVWLFLFVFVYWWSY
The following text describes a protein:
Function:
Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons.
Sequence:
FYSKLLLFYYWRLVGQSASAAFHFLVSGCTNMAATVQKRVLRVLALHGYRQNERSFWERTGALRKRLRGRAELITFNAPLVVPDPDAEPSEGDPDSSQDESRGWWFSNPEQNSFDAIEESNTCSGLDKSLDEVAKVFSELGPFDGILGFSQGAALVAIICALKQQGDPRFHFNFAILVAGFKSRSSDHTKHYQQPITVPSLHVIGETDRVISADMSRELVSHFENPVILIHPGGHYVPACAPQKKVYWEFLDKFLS
The following text describes a protein:
Function:
Essential for normal spermatogenesis and male fertility. Required for normal sperm head morphology, acroplaxome formation, acrosome attachment, and acrosome granule stability. May anchor and stabilize acrosomal adherence to the acroplaxome at least in part by facilitating the presence of F-actin in the subacrosomal space. May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Golgi apparatus. Nucleus.
Sequence:
MWAPQAGIIGDGPAKRGGEQAPLQAHVLQTASLKDGPAKRAVWVRCNRSEPEEPTKSTTVREKPRLEVTKAVVVDLGTGYCKCGFAGLPKPTHNISSTVGKPYMETAKTGDNRKETFVGKELINPEVRLKLVNPLRHGIIVDWDTVQDIWEHLFHKEMKISPEEHAVLVSDPPLSPHTNREKYAEMLFETFSTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTAYLMGLMNNLGKHFTEDQLSIVEDIKKKCCFVALDPIEEKKVPATVHTIQYTLPDGKEISLCQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDNPQVNVLPERDTAVWTGGSILASLQGFQPLWVHRFEYEEHGPFFLYRRCF
The following text describes a protein:
Function:
Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation. Exhibits higher selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. Contributes to the native pacemaker currents in neurons (Ih) (By similarity). May mediate responses to sour stimuli (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Contains six transmembrane segments (S1-S6) and an intervening P-loop. The segment S4 is the voltage-sensor and is characterized by a series of positively charged amino acids at every third position, while the S5-S6 segments together with the P-loop form a centrally located pore of the channel. Contains a cyclic nucleotide-binding domain (CNBD) in their C-terminal region. The CNBD is connected to the pore forming transmembrane segment via the C-linker; Contains a unique pocket located in the cytosolic C-terminal domain, identified as a likely binding site for di-cyclic nucleotides.
Sequence:
MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPRRRSIRLRPLPSPSPSPSAAAAAAGGAESRGAALGGAADGEGPARGAAKSSTNGDCRRFRGSLASLGSRGGGGGGGSTGGGSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGAPAPPAASPPQVPSSCGEQRPADAAVKVEGGAAAGDQILPEAEARLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTDIILDPRRIKMKYLKSWFVVDFVSSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSLNNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPMGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLSSGVSNYQENAIVQRIVQHDREMAHCARRAQATTPVAPAIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGPTTLGSLGAGQTPRHLRRLQSLAPSAPSPASPASSPSQPDTPSSASLHVQPLPGCSTPAGLGSLLPTAGSPPAPTPPTTAGAAGFSHFHRALGGSLSSSDSPLLTPMQSAARSPQQPPPPPGAPAGLGLLEHFLPPPARSPTSSPGQLGQPPGELSPGLGSGPPGTPETPPRQPERLPFAAGASAGASPVAFSPRGGPSPPGHSPGTPRTFPSAPPRASGSHGSLLLPPASSPPPPPPPPAPQRRATPPLAPGRLSQDLKLISASQPALPQDGAQTLRRASPHSSSGESVAALPPFPRAPGRPPGAGPGQHVTLTLPRKASSGSLPPPLSLFGPRAAPAGGPRLTAAPQREPGAKSEPVRSKLPSNL
The following text describes a protein:
Function:
Plus end-directed motor protein required for establishing a bipolar spindle. Associates with both interphase and spindle microtubules. May be involved in nuclear divisions taking place during the development of unfertilized eggs. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Concentrated around the polar ends of both meiotic and mitotic spindles.
Sequence:
MSSQNSFMASKKEDKGKNIQVVVRCRPFNQLERKASSHSVLECDSQRKEVYVRTGEVNDKLGKKTYTFDMVFGPAAKQIEVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSSDEEFTWEQDPLAGIIPRTLHQIFEKLSENGTEFSVKVSLLEIYNEELFDLLSPSPDVGERLQMFDDPRNKRGVIIKGLEEISVHNKDEVYHILERGAARRKTASTLMNAYSSRSHSVFSVTIHMKETTVDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRTKTSIIATVSPASINLEETVSTLDYANRAKSIMNKPEVNQKLTKKALIKEYTEEIERLKRELAAAREKNGVYLSSENYEQLQGKVLSQEEMITEYTEKITAMEEELKSISELFADNKKELEECTTILQCKEKELEETQNHLQESKEQLAQESFVVSAFETTEKKLHGTANKLLSTVRETTRDVSGLHEKLDRKKAVDQHNFQVHENFAEQMDRRFSVIQRTVDDYSVKQQGMLDFYTNSIDDLLGASSSRLSATASAVAKSFASVQETVTKQVSHSVEEILKQETLSSQAKGDLQQLMAAHRTGLEEALRSDLLPVVTAVLDLNSHLSHCLQNFLIVADKIDSHKEDMNSFFTEHSRSLHKLRLDSSSALSSIQSEYESLKEDIATAQSMHSEGVNNLISSLQNQLNLLGMETQQQFSGFLSKGGKLQKSVGSLQQDLDLVSSEAIECISSHHKKLAEQSQDVAVEIRQLAGSNMSTLEESSKQCEKLTSSINTISQESQQWCESAGQKIDSVLEEQVCYLHSSKKHLQNLHKGVEDSCGSSVVEITDRVNAQRQAEEKALTSLVEQVRDDQEMVGEQRLELQEQVQSGLNKVHSYLKEELRNDVPTGTTPQRRDYAYPSLLVKTKPRDVLLEQFRQQQQEYLESISSVISEAVEPPVEQDSLEDEPPVAVNDSVISERSCIDLSMTCQEKGGIRFFQQKKALRKEKENRGNTTLLERSKIMDEVDQALTKSKLPLRMQN
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Sequence:
MIWILGNHSKFSTAWSLIRDLLQMSTDIQEAVLIMIDRYAAANNAGKAIQTFQILEKFSMSPDQRTLLTFLNILCKHGFIEEAEEFMLINKKLFPLEIDGFNIILNGWCNIVVDIFEAKRVWREMSKCCIEPNGTSYSHMISCFSKVRNLFDSLRLYDEMQKRGWVPGMQVYNALVYVLTCENCVKESLKIINKVKHMGLCPDSSTYNLMICPLCESSKLDEARSILALMEEDNISPTIETYHAFLASASLEGTVEVLNTMRKAGVGPNGETFLLILDRFMKLKQPETALTIWLEMKQYEVVPESAHYSLLVGGLLECRLYSKARELYAEMKSNGIDDPGLRKFLQPTGPRGQGGVSNPKHTKNGKLVKHGTHKVIRNEKHTSSEPINISLNMDLSVLFFLLLAAVATTVNATDHIVGANKGWNPGINYTLWANNQTFYAGDYISFRYQKSQYNVFLVNQTGYDNCTIEGALGNWTSGKDFIMLNDTQRYYFICGTGGCLNGMKVSVVVHPLASPPMSAVPAEHSSKKSSAPAARGFVSLLATSFAFFGLTLCGSVWI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTIVSFKDQMWLSSYRLDRNQVFDYFALSPFYDRTCNKEPAENGGYSSFGHALSLLFFAPIRVRVHDTGGGSIYQMRFLYHISNAFAQASANLEKIGSGTDSETGKAGGDADAADVQLKKPTTKVVDVKEVMHVDSILAGVMRLMCQILKLHILVDWPPPAPSRPAPLVPVNNTSPQIETAQALAAPDAEQEQISVGAKQSNTEETTDGKIIKRSPVMRLVLDASSIPLCIIVYFQLIHDEDPIRESVLLDSSHNPTEPSPNTRLQFVLVPRQQLSHF
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAEAAPLGSVDFSVLVRKAAEASVSGLKELTETAPELSDTEKKIGLLKYIVKTRQRLLRIAVLTKWCRQIPLVERCQQLSGTLSNHNMSFTQAADFLFYLHETLQQARAPVYDIPTATEILVAGTYNRLPKCIEDLGMQPVLIGEERGGAVKKLNSVLRTRLLDIELPKQITDIKVRGGRVIFKVAGEFEAHLTLGYRGHLSYWRVLKIDILVGEPSGPTQFTDPQAYFLGDELERRMAASDDPLGLMYSILHQFCTALVMDTLFRQIKALLVGRWRDAIKYEKLSETGGGSGPAAGQASAGQGMGGVGELDVESGSAAKVRGSPGLKIMYWLETQRGEVPPSLRIEHGADQQIRCSHSPAVMDSATGMEAEFAVDSSCINVEKLLLRAISCSVHTRLLEVQRGLKGGVHLWQSDNDVVLRRSIPDELESSCEASGEEENMEEAGEEVLCVRAFGVSHMTLGISIRNGRFLLRCPSTVLAAPMVKEMEDALNLGSVQALDIFMKLRTKCLVHYFGLIGKSLNLKLYERGASSVKVPAEGPKLGGDVLIMGFPDCDESFFLCVQLDANFTPLFTLLEAESQSSSGHASLASSAFNISRWMRIDIEAMPILREDTGFSLLEQSGSEAREGCGSMVVKRVEEEGYSKLGIPPVPKGPSRGGGLGLDGGQSGLDQYYGGGGVSHKGNMLTVHSPSNLQGGSPMQHAGSPLQHGNVGYGVNAGPSMVSPSMSSGGYHQGKSLGGSPAFGDGSHRLGRAGMVNGASPHNMTGVSPLRSPMDVRNQMSHRKSPLQSASEQEPGNTRSPVAVGDNATSPIELDDEHITKLIDSISSKTPGSFATTDSPSRQGRHVPQARGGIGAPTSRPLIGKAGSPSGSQLVRASGLLQASSPGWKSTMSPSGPYMTDSGCPGQDVEQQGRLGGGSDKSPAQKSERKRSITDLFNSMSSVQALATSGQRGKRRRTGLEMVPVPAYQAASHVGVGSTAVSQSVLGQSYGLVVRAANQGKASAGAYRAVFQQVEERCRLCIKHARLTRQMDAQGIPYVNEVGLREPSTVLRFRLPGTVPSGDPRTRPSRSDGSYGWQQMGLCLGKPGSEGWEVKVMDAYFSGLWKLQKQSEGVGGTGEQFASPPQDDSHMQCTQEGLVLKYSTVQDDSVTKLVKDLERIWRARAFAVGIRKLLGSREEQKKRGSEQWGKSQGRGGSVGDTGEAEEKKWEIMRRAFRVEAVGLTSVSFTYVGTTPGIMARFVVEWGTSRRGCTMHSPEQLWPHTKLRTKWFSLAGRKLWSAHRQMRMFLEDYINGGEVELLLDAIQVTAGPLHALAAAIRPARMAAPASGSSHRPSSPSPGTGMAARAGASPAGSGMSSYGSGGAGQGQGQGQGAGANGSVNYGMNSNGGPGTPQGGMPSNSGRNPGPGLVPSSLLPTDVSVLLRSAYWIRIVYRRDFAIDMRCFAGDQVWLQPAPPPRSGGKGGGGSLPCPQFRTFVVEHVTLGMSSSVDSVGGGATGLSSPSTGANSGARQAGGGVGRAGNSVGSTIAAMQGGSGLGGGSRSTATGSGVGGAISIRAELNPALVGMGDDGGYGGAWVPLAALKKVLRGTLRYLGGLWLFAQFPGILREVLASTLNQNEGALLNHDPEQPALRFFIRGCVFAVSMHRQQLFLQAINVNRYKQQQAAAAHQQVAPVMNMAVELSLGEMQDIGDFFARRVASEPYDASRLASFVTMLTLPVPVLREFLILIQWKVATTRANGGPGGDASGQGASPRPQVELSLESQGGGGGGGEKGNSQQDESGVGGGSQGRSSITHNHHRNTVEFTLTFTFDASSLPQLNVAGGAGWLPQSVALRLAYAYGEGVNRISLSSMDGSHGGRSCWARAEEWERCKEGVMRAVQVAPGEGRGRLRALAEQVQMALQTALTQIGRGAGQ
The following text describes a protein:
Function:
Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAPAGQTTYQKDERVLCFHHEILYEAKILDLRHTDPDDRKSPYEYLVHYKGWKNTWDDWVPQDRLRKFTEENRELATTLRREAEAALRQKSTKTSLKKKGGSDHSSARGSEERQTSVPGRGTKRARDNDIEKEEHFYTRPSVRIVMPDNLKSLLVDDWENVTKNQQVVALPAKSSVNQILDDYLKEERPKRTGSSEVDVLEEVVMGIRDYFDKSLDKILLYRFEREQYRVLRKRWESETADKGPLDVYGAEHLTRLFATMPELIAQTNMDLQSTNRLREELSKFTIWLSKNSNHYFATRYVTASNEYIEKSRGVPNPAPGTATSRLV
The following text describes a protein:
Function:
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYFLQNLKVKYKLLALISLAVLGMVIISSVAIHSINKIKHDTEVVVDDYQYSAILLEGMLRTQNSLEYNLLELITASQNEVANKEGIINNIEKDLKKYDSLLKEYDDGFNLSKQEDELFQKMKKSLPSYKDTYKKLFEKAKATNEPQMVNEFQKELKPKGIELAGYAVDLESYVSNLADQVFKDSQKMIDRSVITFIILVVVTTIVICIVSYIISKLIVAPLQTVSRMMERAKEGDLTVHGDYTAKDELGVLVSNFNEMIAGLRTNMQEVENNIQLLFQYADGVASASEVSSSAAKKITMDIEEVANGAESQMQAMEQTAGAMEELTQGMQSIVNTSSSVNELSAQSALDAESGNKLMKQMIQQMDTIQNSVHSGVKQVETMKEQSEEIVKIIDVMQGITSQINLLALNAAIEAARAGESGRGFAIVADEVRKLAEQSSDSAKQIENLITQVMGTTNHTVHMMGKVDNEVQAGTQVVMHTEKVFGTITEKVQQVSEQIQTVSMSTDEIAASSEEISASAEDMAQISQRSSDRTDRVKESIQQQEKSVQEISVSIEHMHDAAGKLKQIVAQFTLQK
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular Localization:
Nucleus.
Sequence:
MCDYFWHRMENDSGELADIVRAGGRSGPSNTEFEPVAAEWRLPSHPPVFFPTRAEIPTNAFGDPFVNLRDPLLDQFTGVEFFDGAEAMVAPASTAAPAGCCSGHVAPKLLLTSEQEMKGPCNVFSRAVHQISPGGSSMSSKPSLLPSRLVRPSPASSGSIAGPADHGGGVQQISSPRPPVIKRRKNQAKKVVCIPAPPPAAAGNRLSGEVVPSDLWAWRKYGQKPIKGSPYPRGYYRCSSSKGCSARKQVERSRTDPNMLVITYTSDHNHPWPTQRNALAGSTRSQPSKNGPRNNLKEEPNKETTSSSGHMVKEEEIGEMEKTIEQAGDTLGFDPMIHPSYKSDQPDDLFAGLAELEGDPMSLIFSRGFMESKPDEEKGVGASDAFDMFDWAGGSSRSQEEEVYYKTLEK
The following text describes a protein:
Function:
Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
MVDLRKKISRMALVVTCYYFIHISYKYAYATSVSGTSRTVAGNGNVNHRLPRTSASYFGSGASANTNFKTVTKSKNVTRYGNIHIREQQLLNIFEVIIDTLEGKLKRIDSLDNTVDLLMKNMETLQNRVVNNVLKTDFIISQLKNIEKTISNEMLQGQSSNLNVAYETTKITQNSSTLLKEQIVNLDRKVSDIDNKLECMKVQLDNNLLHVEDFNAEASEKKPVTINVNDVTKALSYVAMTQVTSELSELRDSTDNIDKKLQFYINIASENIGKMTSMMHEIHCAVVHHNNQFKFLNVTTHSKSNNINKLVKEIRPMGVVSEQNDNVWDVGVDTKSTDGHLLSKSTAPLSQTQRQERAIDEIHHDKKPKSYLNINNFDMVKKQFEKQENFKPPEEISETRIKEALEYESKNYTDTDENSRTEILLLSLSNIQPTIVNKTITTPFTSTPGDGDVLGPLHSESLDSNRTHYNGPAVNGLKSANRKDRIIFPSIKKKPAFLNTTISNDFWALKDVKGFSCVDILNAGMKQSGVFYLQIRGTTYWFLKVYCDQETTDGGWTVIQRRDDFKDSRENFNRDWADYKNGFGEPSKDFWLGNENIYMLTNNEEYSLRVELEDFEGNKRYAQYSHFKIHSEADYYKLEIDGYEGNAGDSLNDPWYGSNNSPFSTYNKDNDRSSLNCASMLKGGWWWKSCGRGLNGLYLHDPQDITARQGIVWFRWRGWDYTLKKSKMMIRPRIPPQQTISGTSL
The following text describes a protein:
Function:
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.
Subcellular Localization:
Chromosome. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MPSCTASTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRAFPEHSPEPSNWATEMLLPEADLWGNPAEEDAFGLGGLGSLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRPPAAGPAVPVPGAGTASPAGRGHGPAAGASRAGAALPAELAHPAAECVDPAVVFPFPVSKREPAPAPAAPAGAPAAGAAVVSGVSATAPTGALGAALPRAGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNSKAVTTFTITVRPKGAALGTGRAPAGELILKRCVPIHQQHNYAAPSPYMESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MAQLRSYQRQLFAALVTGRSVPPEARFSPGGNSKPYSWLERPWLCVCVNSELFTLTYGALVTQLCKDYENDEDVNKQLEKMGYNIGVRLIEDFLARSSIGRCHDFRETADVIAKVAFKMYLGITPTITNWSPAGDEFSLILENNPLVDFVELPDNHSTLVYSNLLCGVLRGALEMASDNFFFFNTTM