lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
Sequence:
MRPPKKQRGRSPLSARGKGTRKRGGKLDGHSQTTPPAPSHQKYTPSKEDSSQDKQIKSSNMTNSEGLKGQIKERTMETSKSEETAGIVNKAKSPKNINTNNLTDNTDSIKIASNAHENSHSNSTDICNTNTQNLTSTNSKSSNQHTNSTASNTQNTNNIGNSLNKSSSLSANHTSTTLSSRKTATFKARVPKKKYMYEHQATSTSPISSKPVTQLTLHINHLGSPQNSISQNTTPVIRNDLFKASTSDLDDSGNSRSRLEIANIASTETSKGDRIMGDMLKSEVPSEVEKVIQMVEADGYGEQAPNSVRSSSTDTASEHSVDLEVLEPSCMQLNSGNHVRASRRFNPLNNSTLSVVLSPNHTQVEQEGSATVAETLAKGLKNQRVLARRRPRRSLKEDEKLVKECIFICGVVRGSNKEQLNVELQINGEGTLLSYPFHTLVSRPHQPIDLILDAPPPGNELVEVGTRVCVPYGGDKEKEWYREGVVAQVDSHSACPYMVLLQEEQKKERCSKEETKQTSSSVWVARQNLRLLVPPWDGVMREKEREEREHREEIEVERELCQLSEGMDLVTAGPPRENCRFPSPDTGAHRYESTLSSSTSPAVVMVANNMFGLASRGENEGTENRERVREREHERKQLQTPEVDMEVLRLNMAPLRDSGGPLVSGGPKTGAPNQHRQILSKPPGYPSPITVVRGISGTTLGSPQPTPSSVVLGSDGGNSHHISPSVPPSPSSRGSLTPLDKTPTPSQTSTPVPGSSASSASSSRSRTPLSAVQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSREGCMKESQRRGYCSRHLSMRTKEMEGAVGERGSGGGGESSSGTVTPSDLRGRASSEFEWDETSRDSSETSSRGTDSRPRLGLPSLLPQDFSRFDFDECEAATMLVSLGSRSVTPSFSPISNQSPFSPTPSPSASPLFGFHPANFSPITASPVLPHRRHKHPSGTNSGLPKHGTGGTEREKDRHLSGIVPSFHPNLTFTVPMSPGKRRTDAPPPPVPLLQEYTKPDQEQSCRDPSLVTNLCIISPQTTTVTHPQRLLSTTASSSPASPLSLESGSQCTISQQPLRDSPVIVRNPEVPLIKFTELPLARVAEVDRTSFTENSQTGVHPETGLQVPVPINAASTNGSVLLQNPTSTLVLVSTTSSIPNPNPAGLPTQPSATLACISVPSPVSGAGLIGAGDGGGQDKSCPATLQQPVPCHPAPTALLPLILPTETLHPVPCKDIIMGRPGTVWTNVEPRSVPVFPWHSLVPFLAPTQSDPSAQPGEGQQTVSHPQTAALKKESQSGSVLKEIIEGAPNPSSRPTPSADELPPEREKDAERERPDSETESDVDDPFFPGVLPDPPISASPGKRRSQSLSALPKDDKNSPGKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEGRGVPGGKDIRERSMSETTEPPSVSMGMELKGMGPGMVSVSERVGGEGHGQLTRPRAFSQSAMHSLERSERGNPQALAELAQMCGDGSQVGGRGALSQTQRGVSEDMTSDDERMVICEEEGDDDVIEDSYPGSSIDLKCKERVTDSDSENGSGDEGERKRVFAPVICSSSYGPGHGRSVSLSSYPTSRRFSDTSSKRKRTIEAGDGEQREGEGGASQPSAGQSILVSSGGGVSSMLGAVRVASTVVTNVVRPVVSTPVPIASKSPHDRKLAPSQTQLLIGHGATGNTAAASAGGGGYYSSSSPSPINAPAGQAGLVTNLVLGGTFQAPPAVQLVTPPPPSQNPASPAHSNGPLPLPVLQSHILPSGSLAPSSGQKPITQVQYILPTLSANNPKSPSPQQASQPTSIFTLPTALPTHATLANGKQSGYVSSPVGVVSPGARVQTQSPVLQGKMLVPMATVRAAPAPSPQFPLVAPPLPVQNGAQAGSKIIQIAPMPVVQSQLPSAGPVQPGSPFSVTMGTATVVAPGSTPSQTVLLPPPPTRITYVQSTPGVPSPLPLVPSTTGSSSQTVSAAPGSAYVSSPLATFAAIAHPGQTLVQPLIAGQPSLLAPAQSPNPPHAPAITALYTPTNVTLATGVVSMATVSPSVVYTVSSSSSLSPHILPKHTTATSMTPVTLDRQVNVSVHSERQLHQERSLERQHTDSQVYTLSSERQTEKGCLLQLDKHFQVPSKGSSSSVAPPSATSVPLQPGSPAQPSHSGSAPGTPKLITARPPQKVKATLANIPVGSYDGGGRGKEREKERDRDKEREREKDKDTSSRFSFEVEKVEKIEKSNSPAEEGAPETPTHFGVETSAPSGRCKETNAKEVEKKDSHPSSPLPPPSGSDPSPSQSHGDKDAPPKKVKARPPPLKRPFDSVDKVLSEVYFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRRKRKNSTDLDSSTEDPISPKRKSRRRSSCSSEPNTPKSAAKCEGDIFTFDRPDGEDILGELEFDKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPTKVCLQLKIREVRQKIMQTAAPSESAGISDLSLPGPSGVVTMDPALGADPLEKEVEREGEQHSPEEPRNAGDSQDSSR
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEEEGYQWARRCGNNAVEDPFVYEPPLFFLPQDQHHMHGLMPNEDFIANKFVTSTLYSGPRIQDIANALALVEPLTHPVREISKSTVPLLERSTLSKVDRYTLKVKNNSNGMCDDGYKWRKYGQKSIKNSPNPRSYYKCTNPICNAKKQVERSIDESNTYIITYEGFHFHYTYPFFLPDKTRQWPNKKTKIHKHNAQDMNKKSQTQEESKEAQLGELTNQNHPVNKAQENTPANLEEGLFFPVDQCRPQQGLLEDVVAPAMKNIPTRDSVLTAS
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDGGTFDIQPIGRFYGSNTTIRRPREITCFSYDAEHKFHLGDSSLRYYYTPRLPADLNRGFDTFQKLDDTADEHLDALLETIMALEKETGKRCEADIITWRGMMTKILTAPFDNLNGFEMNATCFQVGGENNLYKIQQKQIQENQRMPPGMASQDLMAYWGYKFETLCLLQQPWDPTPRAEIESREDLVVNNNAQYCSVVRTGIGSTRLIIGGEVDAVWDCKPDRKEDPINWVELKTSAEIRNDRDMIKYERKLLKFWAQSFLLGVPKIIVGFRDNHGIVHRLEELETASIPNKVKKLGRGTWDGNICINFAAAFLEWLKSTIKEGGTWRIRKLEKSSLIQVFKIEETGTGDIISRSFLDWRSRS
The following text describes a protein:
Function:
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDMTGLPGTSKHIIFLLLCQLSASSRGDSCCVEKISYPDEASGPSLGPRDLSCYRVSGTDYECSWQYDGPEDNVAHFLWCCFAHPNPTHTSFGQECCCYFSSGRSRTVQFWEQDGISTLSKVNFWVESRLGNRTLKSQEISQYLYNWTKLTPPLGHIRVSRSRGELRMDWNVSDGAGAEVQLRRRMPTTNWTLGDCGPQVSSGLGVIGDIHGSSSESCLCPSENMAQEIQIRRRRRLSSGAPGGPWSNWSMSVCVPPEFLPQAEIKFLVEPLNQDGRRRLTMEGQTPQLAVPEGCRDRPGAQVKKHLVLVHMLACRCQARTWKTVPLGKTLDLSGAAYDLDVLAQTRFGRSIIQKWPLPAQELTETRTLNVIVEGNVTSMQWAAQPPGTAYCLEWQPWGQDRNHTDCTLIAPEEEDPAKMVTHTWSSKPTLDQEECYRITVFASKNPKNPMMWATVLSSYYFGGNVSRVGTPRHVSVRNHTEDSVSVEWTASQLSTCPGVLTQYVVRCEAEDGTWESELLVPPTKTQVTLNSLRSRVVYKVQVRADTAMLPGSWSRPQRFSVEVQISRLSIVFASLGSFASVLLVGSLGYIGLNRAAWHLCPPLPTPCGSTAVEFPGSQDKQAWQWRNPEDFPEVLYPRDALVVEMPRDRDDETESPQATPERALDTRWPLGTEGQVQGLSEARLPDLAREDCPRGDLAHVTLPLLLGDVTQGASVLGDLWWIHKTVEPGPPTLGQEA
The following text describes a protein:
Function:
Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Promotes oscillatory nuclear movement and efficient pairing of homologous centromeres during meiotic prophase.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Localized to the leading edge of the horsetail nucleus, where the spindle pole body (SPB) is expected, and to the leading microtubules. In cycling cells, forms foci which distributed asymmetrically during cell division.
Sequence:
MDELLEKLLNDLKKKEPKACSIICIGEDLDIIQCMNEHGCFSGGSYSELSNDCETVNFRGIAYKCFFTKDQVKVNFWQISHLTGGLFNFLVSQALNEHGLDLLWIIMVVAQTLSALVSFPEKLLNILRNMKTILINTEETVRNRFEESQNKKLVALLDKNSTTLDISSGILLNFTVVLKQLKHALGLHTSVDNSQEFILQFLRTTLLSVPTSSIVSISADPTSWNNLNVLMKYNFMFQKFKPRDFHAQTIQSETMFIPPCWDTISKIQSVNHEFNIALFKQTAKNFYDTLDISLLLGLFDKSISMLNCHSSKISDGDIPYKSHQVFLQELQNKYSEIKTYSSNKLNKSSIKSSLWKDLIQ
The following text describes a protein:
Function:
DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance.
Subcellular Localization:
Nucleus.
Sequence:
MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFASSLASRVPLLDYGYPLMPTPTLLAPHAHHPLHKGDHHHPYFLTTSGMPVPALFPHPQHAELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDEPKAPEGPESPEGSPRGSEAATAAEARLSLPAGPFVLTEPEDEVDIGDEGELGSGPHVL
The following text describes a protein:
Function:
Pyrophosphatase active in both inorganic pyrophosphate hydrolysis and H(+) translocation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MMMDEDVEQASLMSFNDRPRAFPNMRSKTYSPLIFRIIRKLNVRVLSIILLFCFGAIFYMGASTSPIIVFVFTVCIISFLLSIYLTKWVLAKDEGPPEMVEISDAIRDGAEGFFRTQYSTISKMAILLAFVILCIYLFRSLTPQQEAAGLGRAMSAYITVAAFLLGALCSGIAGYVGMWVSVRANVRVSSAARRSAREALQIAVRAGGFSALVVVGMAVIGIAILYSTFYVWLGVGSPGSMNVTDLPLLLVGYGFGASFVALFAQLGGGIYTKGADVGADLVGKVEQGIPEDDPRNPAVIADLVGDNVGDCAARGADLFESIAAEIISAMILGGTMAKKCKIEDPSGFILFPLVVHSFDLIISSIGILSIKGTRDASVKSPVEDPMAVLQKGYSLTIILAVITFGASTRWLLYTEQAPSAWFNFALCGLVGIITAYIFVWISKYYTDYKHEPVRTLALASSTGHGTNIIAGVSLGLESTALPVLTISVAIISAYWLGNTSGLVDENGIPTGGLFGTAVATMGMLSTAAYVLTMDMFGPIADNAGGIVEMSQQPESVREITDLLDAVGNTTKATTKGFAIGSAALASFLLFSAYMDEVSAFANVSFKEVDIAIPEVFVGGLLGAMLIFLFSAWACAAVGRTAQEVVNEVRRQFIERPGIMEYKEKPDYSRCVAIVASAALREMIKPGALAIASPIVVGLVFRILGYYTGQPLLGAKVVASMLMFATVCGILMALFLNTAGGAWDNAKKYIETGALGGKGSEAHKAAVTGDTVGDPFKDTAGPSIHVLIKMLATITLVMAPVFL
The following text describes a protein:
Function:
Controls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth.
Miscellaneous:
MISCELLANEOUS: Present with 98 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch.
Sequence:
MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQLSKTPSVTIKSYPDTDLSSDSNYLEVKSCIFNGLLGLVCLNGDIYVAVISGVQNVGFPRWKLIDHQVRPSESIYKVLDVDFYSLENDVFDYLLCERSEQNYDKLIHEHPCGPLKKLFSDGTFYYSRDFDISNIVKNHGLSHNLEYTVDNQDLSFIWNANLASEVINWRSKISNEEKQLFANAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETEIVVTTEKFIFSYTQVNGSIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTSKYGVVSIVNIIKPKSESQEKLALTYKDCAESKGIKITNIEYSSSVLTKSPHKLLYLLKQDIYEFGAFAYDISRGIYFAKQTGVLRISAFDSIEKPNTVERLVSKEVLELTTNEIDVFELTSPFLDAHDKLWSENYYWLDRTYTKHTKNSGKYTKVYSKLFGSRVRLYDPLHIYISQYLKQLRSKYTFEKDISIFAGTFNISGKIPKDDIKDWIFPKSMSKEDEMADLYVIGLEEVVELTPGHMLATDPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDHDAIIWMGDFNYRILMSNEDVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTKNYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQKKTTLGTQIYEKIMERLEGLDDDEKIAVLSDDAFVIESFEGSDSIAGPTHSPTPIPEPKRGRKLPPPSSDLKKWWIGSGKQVKVVLDVDPAVYMINPKRDPNPFVENEDEPLFIER
The following text describes a protein:
Function:
Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular Localization:
Secreted.
Sequence:
MPGAASIVAVLAALLPTALGQANQSYVDYNIEANPDLFSECLETGGTSFPDCESGPLSKTLVCDTSAKPHDRAAALVSLLTFEELVNNTANTGHGAPRIGLPAYQVWNEALHGVAHADFSDAGGFSWSTSFPQPISTMAALNRTLIHQIATIISTQGRAFMNAGRYGLDVYSPNINTFRHPVWGRGQETPGEDAYCLASTYAYEYITGIQGGVDANPLKLIATAKHYAGYDIENWDNHSRLGNDMQITQQDLAEYYTPQFLVASRDAKVHSVMCSYNAVNGVPSCSNSFFLQTLLRDTFDFVEDGYVSGDCGAVYNVFNPHGYATNESSAAADSIRAGTDIDCGVSYPRHFQESFHDQEVSRQDLERGVTRLYASLIRAGYFDGKTSPYRNITWSDVVSTNAQNLSYEAAAQSIVLLKNDGILPLTSTSSSTKTIALIGPWANATTQMLGNYYGPAPYLISPLQAFQDSEYKITYTIGTNTTTDPDSTSQSTALTTAKEADLIIFAGGIDNTLETEAQDRSNITWPSNQLSLITKLADLGKPLIVLQMGGGQVDSSALKNNKNVNALIWGGYPGQSGGQALADIITGKRAPAARLVTTQYPAEYAEVFPAIDMNLRPNGSNPGQTYMWYTGTPVYEFGHGLFYTNFTASASASSGTKNRTSFNIDEVLGRPHLGYKLVEQMPLLNFTVDVKNTGDRVSDYTAMAFVNTTAGPAPHPNKWLVGFDRLSAVEPGSAKTMVIPVTVDSLARTDEEGNRVLYPGRYEVALNNEREVVLGFTLTGEKAVLFKWPKEEQLIAPQ
The following text describes a protein:
Function:
Putative zinc finger that may be involved in programmed cell death and defense response.
Subcellular Localization:
Nucleus.
Sequence:
MEEIQQQTQKEEQKHREEEEEEEEGPPPGWESAVLPPPIVTITAAVNPNPTTVEIPEKAQMVCGSCRRLLSYLRGSKHVKCSSCQTVNLVLEANQVGQVNCNNCKLLLMYPYGAPAVRCSSCNSVTDISENNKRPPWSEQQGPLKSLSSLRRAEN
The following text describes a protein:
Function:
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space.
Sequence:
MKLLRSVVLKLFLAAVLSASVTGESLGRLRRGLAAGTGNPDSPTESTDRLLPPEGGRAREVLDLEETDLDLLRAAFSSKPQALATPSKEERGKKKKKGKGLGRKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVESEEKVKLGMTTSH
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MGASASLFLSVLCVRALRGLHCLLPLFAVVFELSWDVAAPSMLTEFIGWSTHQQNRKSLPIFNSFDKESHRLLFLDAQVYFALKQNTGGPPSHYRLFPLSLSLSVCTTMAAAAAGIKVSPEELRENKVPLAFRDACADFLISLNKCRTENRFLPWKCEHQMHEYEGCQYGQIIAVANIYPHGSVQGFCCQTQHSRT
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB31 (By similarity).
Sequence:
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHLPTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MTEEVQQLSTGDKYFIEQRSLILQEINESMDAILNQLNGLNITLENSIAVGKEFENVSQIWKLFYNGLESEEQNMETVGVADSEHITEDVNPEGK
The following text describes a protein:
Function:
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with sfc6 in DNA binding. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.
Subcellular Localization:
Nucleus envelope.
Sequence:
MDSLIRHCSEEIALDGSSGCSIDRLWEFAANFFFRQGIVQNLDDNYKTFVWPLILKEDGIEVWIEDEDATGLRSKMQEIPWNYQDITIELRARIRLFASEDRQWLTLTYKTKTDSKIQPLAFELLSCISRYRQEGVDRIQLCKETKQEPRSVYGRIQALEDASLISKVAINRSRAQTALLVLKRFESENSTINETVAQVSGKQIYNTEKIRSNICDAVQSSRNGICRHVDARAMVNLNHSRWERRYYARQVTYLHNNGYLRKCLTFVPNSPERCIRCLQFIKPYISSLDATEDDVDFTEVDDIPEDDELEEEEPLLPSKEEFDASFLQPLADVGPTLPQWSRFRPLEFQCFVLIRNAGFHGVITLQILSGLTGIRFNKPLFKLLGSLVEHRSSVPNHLSHMSITRFEDKTKKSRQYRYFTLQSQLNRLIRDGIPAETISKLLPHVHSLAGEFSPIDSSLFLNSLHHKGNMESNAEVSPDGMTLLPRKRGRPRKSANISVTSSPIRPSKNENNLPSLAISPVSEGFIQNATISTPSTSSNLSIAGSLTPSKTSRIYRGLAPLKNPEFNEDHVKKAEHLEPLLNVSSSVPSKNFTVSSPDHLKYGNTSSLQVSDSQSSIDLDSSFHYPVSVDSQLSHSTGSLMANFSSPTKKRRLESVDFIFLQRKGLILSYLVEQNGAFEISRKMFEDLADLKVRRNPETSRTVMDRRTFQQTLEKLMQEKKVRKLVIATNNGLGKLVRKDIVVQYDMKPDSPRFQQLRAQITTPEIEKQSTPEILKDVDVDFLKRNTSLSRRKSMPAEIKRHKESSETKPVDKEEVKKNEKEKDDPMRLAQQLLESLAPDFALHENTQQKSPVEKPKKLRKDRYASVEEFDYFSSTEHASKRSVKRFKNDFTSDEDETLIRAVVITQIYYGGTNRLIKWEAVQKCFPNRDIYALTRRYLSIRQHTKFKGLQQFLSENWQQMYKDAVSRKDLMPYPDSVDDFDPTPYVKASCRPYMISSSNLATTRLPRDLVDVYETYNIEVVKQETNFREMIFDPSLSVASKMNAYCDMPFTMPLSLNDKQNNEGDENCEKGQLFDAKSTIKSIVAIPDATYDARFSQERLMQYPEDILIAAHQELLDKRIITRVNSENSRLQPGRNFQFTEKFASSLKSPLPPFLLSQAKRFNKFLLEGFQNHKNHLFEETSNSGTLACILDLLSQGKLQISIVGSKFNEYGLSEGYRTRLLEHDNINVTLVLSGKESESKKNYGVTEKLATPPSHEPRLWLNGKCELIEMIWMNIEQSIVYQLLRKPGILRSQLTNLLFPGLEPREFNEVLDYFIAAGAAIEKDGLYLNHNYLFKLT
The following text describes a protein:
Function:
Transcription factor involved in the circadian clock. Binds to the promoter region of APRR1/TOC1 and TCP21/CHE to repress their transcription. Represses both CCA1 and itself. May recognize the promoter of JMJ14 to regulates its expression during the night in a circadian manner.
Miscellaneous:
MISCELLANEOUS: CCA1 and LHY are only partially redundant, but they bind to the same region of the promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDTNTSGEELLAKARKPYTITKQRERWTEDEHERFLEALRLYGRAWQRIEEHIGTKTAVQIRSHAQKFFTKLEKEAEVKGIPVCQALDIEIPPPRPKRKPNTPYPRKPGNNGTSSSQVSSAKDAKLVSSASSSQLNQAFLDLEKMPFSEKTSTGKENQDENCSGVSTVNKYPLPTKQVSGDIETSKTSTVDNAVQDVPKKNKDKDGNDGTTVHSMQNYPWHFHADIVNGNIAKCPQNHPSGMVSQDFMFHPMREETHGHANLQATTASATTTASHQAFPACHSQDDYRSFLQISSTFSNLIMSTLLQNPAAHAAATFAASVWPYASVGNSGDSSTPMSSSPPSITAIAAATVAAATAWWASHGLLPVCAPAPITCVPFSTVAVPTPAMTEMDTVENTQPFEKQNTALQDQNLASKSPASSSDDSDETGVTKLNADSKTNDDKIEEVVVTAAVHDSNTAQKKNLVDRSSCGSNTPSGSDAETDALDKMEKDKEDVKETDENQPDVIELNNRKIKMRDNNSNNNATTDSWKEVSEEGRIAFQALFARERLPQSFSPPQVAENVNRKQSDTSMPLAPNFKSQDSCAADQEGVVMIGVGTCKSLKTRQTGFKPYKRCSMEVKESQVGNINNQSDEKVCKRLRLEGEAST
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMSPHLLPSTSIPKASAALLLRPAFPRMTTLTRFYATQSDLGGGSGSKATPRRRNVTVLSDDGRYEWGELSGREKVARATQQSLNFLVIVAGAVLTGGVFYLLYTEVFSPNSRTWQFEKAVQRIKDDPRCTDLLGDRREIKAYGESTGSRWERNRPIATSMFKDRQGREHMKMHFHVEGPLNSGIVIVHMMKPLDKDEWEYLLLALDVKGHSRVILEQAQEKPGVAKALKIFGIQWR
The following text describes a protein:
Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (By similarity). Required for neural crest migration and eye development.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGGLEKKKYERGSATNYITRNKARKKLQLSLPDFRRLCILKGIYPHEPKHKKKVNKGSTAPRTFYLLKDIKFLLHEPIVGKFREYKVFVRRLRKAYGKREWDSVDRIRDNKPSYKLDHIIKERYPTFIDAVRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLSVEFLNYVIDSRSLRKVFLSIKGIYYQADILGQTLTWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFHLYQTLNLQYPPKLDSFSEVDLKSDGEDKYALETEVYMEKLAALSASLSRVIPSEPNDDTEVDEFPADPENAGLEEEQKRQLQEEEKHKSLFVGLKFFLNREVPRDALAFIIRSFGGEVSWDASVCIGATYNSTDPSITHHIVDRPSIQTQIINRYYLQPQWVFDCVNARLLLPVEDYFPGVLLPPHLSPFVHEKEGDYIPPEKLRLMAMQKGENLGLDEEDDDDDDDDEEEDDDDDEEEEDKKLRQLENKKVGQKNLNVKVTAGKVKVEDRTQVAEQEKNEEKRLAIMMMKKKEKYLYNKIMFGKKRKVREANKLALKRKAHDEAVKVERKKKAKKH
The following text describes a protein:
Function:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Miscellaneous:
MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22; MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice site.
Subcellular Localization:
Nucleus.
Domain:
The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
Sequence:
MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVAALRHLDSAAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGNLVRAEAGAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVLKHADGLAVPTVVLEVEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRARKGMVLDPTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGPVPHYPAPDGVKLAAGWLVERAGFGKGYPDAGAAPCRLSTKHALALTNRGGATAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML
The following text describes a protein:
Function:
Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
MLHCSQWLRHRVNDRGGTAHNFAFDALTKVYRDAVYGNNLSHSGNSVTPGHSAAAASTASPTSPAEMQHQLPRGPRLSGVQREILQLYRDLLKETRRMRDLRTQANLRRFIRSEFDKSANISRKYITRIEWQMNYGKNKLDELRHMSPDMRFSLVH
The following text describes a protein:
Function:
Ubiquitin-protein ligase that may function as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chain assembly on substrates monoubiquitinated by another E3 ubiquitin ligase.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The U-box domain is required for the ubiquitin protein ligase activity.
Sequence:
MATSKPQRSPAEIEDIILRKIFYVTLTESTDSDPRIVYLEMTAAEILSEGKELLLSRDLMERVLIDRLSGDFSDAEPPFPYLIGCHRRAYDESKKIQSMKDKNLRSEMEIVTKQAKKLAVSYCRIHLGNPDMFGNSDKPSGGLDNRLKKRNVSPVLPLIFAEVGSGSLDMFGASSSGVQAPPGFLDEFFKDSDFDSLDSILKELYEDLRSTVINVSVLGDFQPPLRALKYLVSLPVGAKSLVSHEWWVPRGAYMNGRAMELTSILGPFFHISALPDNTLFKSQPDVGQQCFSEASERRPADLLSSFSTIKNFMNILYSGLHDVLMILLKSTDTRERVLQFLAEVINANASRAHIQVDPVSCASSGMFVNLSAVMLRLCEPFLDPHLTKRDKIDPKYAFCGHRLKLSDLTALHASSEEVTEWIGKDAMANANDAGRENGNESRLLQSKEATSSSSNASGQNAKSATKYTFICECFFMTARVLNLGLLKALSDFKHLAQDISRGEDNLATLKAMRDQAPSPQLELDISRMEKELELSSQEKLCHEAQILRDGDFIQRALSFYRLMVVWLVGLVGGFKMPLPSTCPMEFSCMPEHFVEDAMELLIFASRIPKALDGVPLDDFMNFIIMFMASPEYVRNPYLRAKMVEVLNCWMPRSSSSSSATSTLFEGHQLSLEYLVRNLLKLYVDIEFTGSHTQFYDKFNIRHNIAELLEYLWQVPSHRNAWRRIAKDEEKGVYLNFLNFLVNDSIYLLDESLNKILEIKQIEADMSNTAEWEQRPTQERQERTRLFHSQENIVRIDMKLANEDVTMLAFTSEEITAPFLLPEMVERVANMLNYFLLQLVGPQRKSLSLKDPEKYEFRPKQLLKQIVRIYVNLARGDTVNIFPGAISSDGRSYNEQLFNAGADVLRRIGEEGRIIQEFMELGTKAKAAASEALDAEAALGEIPDEFLDPIQYTLMRDPVILPSSRITVDRPIIQRHLLSDNHDPFNRAHLTSDMLIPDIELKAKIDEFVKSHQSKKRTSGEDSSNKERIQTTNSDMLID
The following text describes a protein:
Function:
Component of the cuticle of the larva.
Sequence:
MKFLIVFVALFAVALAAPAAEEPTIVRSESDVGPESFKYDWETSDGQAAQAVGQLNDIGTENEAISVSGSYRFIADDGQTYQVNYIADKNGFQPQGAHLPVAPVA