lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Subcellular Localization:
Nucleus.
Sequence:
MATSSVSKGCFVFKPSSKKRRRTLSIEDYFQNDNIDPETSTLRFQTCQSLWEQMKTEVEVFQEELNKKILDRLLEFARKTTATSRSTADDWASRMRSSEIPTAALVLGVNVPDHDVTLRRLSELLQQSATPFVVSLQSKECSALKQMVQKVLLQLMGCTVSLDEEEEEQPALSEAADLPRKRAHCSLATLCDWYQAVQKKAAVPSPCKSRGSPGDGVGQSPPVVVIFKDFEGFNPRVLQDFIIICSQYIQKLPLTFVFGIATSPITIHHVLPHSVSSLLCIELFQSVPCTEHLAMVIDKLVLTTQFPLKLSGKVLRVLIGIFLYHDFSVRNFIKGLQLALLEHFYNSPLSVLCCKKREALSRAQQLSHENCEGVRRLPSFMRYIENQEPQEQIELLTNDQHLKDVCQRLLRDLHTYHKQYYPVLRCLHTLTATLPKHPLGKQIRELHVTCLERNVWECEEYASALQLLRTPVPKMVLEGRVKRLLIKRCWVVIMVLLTPATDHSCFSVQETLAVFHREDRSAEGECTEEGEDASPRPRLQKKTDLFHLQKTLLEMKESRRTKKLSRFEVLRNEALDFIETLVKYVLFKFALQTSVHCCDDSAERLFFANLASSCLSLKFLCYPLNLPKNDALKSEEGAISNAAPDICIVYKLHLECGRLINLYDWLEAYRTVVAAAEGKDRDGTEAGTFDEEKHARFIRAVSELEFLGFVKNTKQKTDHVARLTWGGC
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 16000 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MGTITVVINEGPILLIRALHRATTNKKMFRSTVWRRFASTGEIAKAKLDEFLIYHKTDAKLKPFIYRPKNAQILLTKDIRDPKTREPLQPRPPVKPLSKQTLNDFIYSVEPNSTELLDWFKEWTGTSIRKRAIWTYISPIHVQKMLTASFFKIGKYAHMVGLLYGIEHKFLKAQNPSVFDIEHFFNTNIMCALHRNRLKDYKDAEIAQRKLQVAWKKVLNRKNNTGLANILVATLGRQIGFTPELTGLQPVDISLPDIPNSSSGAELKDLLSKYEGIYLIARTLLDIDQHNAQYLELQEFIRQYQNALSESSDPYDTHLKALGLLETPPPQESTEKEEK
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKIYANQSRTMTAWRATSKGHEQQQLPQQQKQQQEAGSSSSSNSSSNNLVATPATSRHCNLHLIVMIILACCTRWLYGLPDGRATCRSVPGLTKDQVELCYKASDVTAAALEGLDMAIRECQIQFQWHRWNCSSLSTKSRNPHASSLLKKGYRESAFAFAISAAGVAHSVARACSQGRLMSCGCDPTINRKTLNKNLRQSLDKEKKQFLQYLETNQILTPEEEKKYERSKIASRWKWGGCSHNMDFGVEYSKLFLDCREKAGDIQSKINLHNNHAGRIAVSNNMEFRCKCHGMSGSCQLKTCWKSAPDFHIVGKVLKHQFRKAILVDQSNLGNGEPVVVLKRARNKKSNGGSGSGSTSPDLDSTDASGGHDDGGTGDSETRRHDELGVERGTRQPSADKNAARMARKLETSLFYYQRSPNFCERDLGADIQGTVGRKCNRNTTTSDGCTSLCCGRGHSQVIQRRAERCHCKFQWCCNVECEECHVEEWISICN
The following text describes a protein:
Function:
Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport.
Subcellular Localization:
Periplasm.
Sequence:
MKRSISFRPTLLALVLATNFPVAHAAVPKDMLVIGKAADPQTLDPAVTIDNNDWTVTYPSYQRLVQYKTDGDKGSTDVEGDLASSWKASDDQKEWTFTLKDNAKFADGTPVTAEAVKLSFERLLKIGQGPAEAFPKDLKIDAPDEHTVKFTLSQPFAPFLYTLANDGASIINPAVLKEHAADDARGFLAQNTAGSGPFMLKSWQKGQQLVLVPNPHYPGNKPNFKRVSVKIIGESASRRLQLSRGDIDIADALPVDQLNALKQENKVNVAEYPSLRVTYLYLNNSKAPLNQADLRRAISWSTDYQGMVNGILSGNGKQMRGPIPEGMWGYDATAMQYNHDETKAKAEWDKVTSKPTSLTFLYSDNDPNWEPIALATQSSLNKLGIIVKLEKLANATMRDRVGKGDYDIAIGNWSPDFADPYMFMNYWFESDKKGLPGNRSFYENSEVDKLLRNALATTDQTQRTRDYQQAQKIVIDDAAYVYLFQKNYQLAMNKEVKGFVFNPMLEQVFNINTMSK
The following text describes a protein:
Function:
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Has a cGMP-stimulating activity (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MTALVLWGLLLLLGQHTQVNSHVLGRPFSASDSSQLKSLLERLEETISEADQEQNPELDQEVEYDIRDQDPGQRWNLDLGRDQDQVTATRSEIHSRPSVQRSHLQDLLMSLRKRASSCFGARMDRIGNASGLGCNNGRG
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Forms part of the polypeptide exit tunnel.
Sequence:
MQVTVRDLDGDDAGTLDLPRVFEEPVRPDLVKRAVLAAQANRTQEYGADEYAGLRTTAESQGSGRGMAHVPKANGQGARVPQTVGGRKAHPPKAEKDHGLDVNDKERKAAVRAAVAATTDSELVADRGHNFDDDVEFPLVVSDDFEDLVKTQDVVSLLEALGVHADIERADEGRTVRAGQGTLRGRKYQEPTSILFVTASESGPSTAARNLAGVDVATGREVNAEDLAPGAEPGRLTVWTESAVEEVAQR
The following text describes a protein:
Function:
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein. Probably acts together with the monothiol glutaredoxin GRX5, earlier than BOL3 and NFU1 in the [4Fe-4S] cluster insertion process. Not required for [2Fe-2S] cluster insertion into mitochondrial proteins.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFKRAMSTDGPVARTILKRLECGFPDYKNFAFGLYNDSHKHKGHAGVQGNVSAETHFRIEMVSKKFEGLKLPQRHRMVYSLLQDEMAQANGIHALQLSLKTPQEYESKAK
The following text describes a protein:
Function:
Part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). Hmg1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate. The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase eg10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases erg13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hcs1 (Probable).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
Sequence:
MIYKLAARYPIQVIAIVGILVSMAYFSFLEALTQEDFPVLIRALKRFGILDGFPNTRLPNEMILKLSSVQGEDASVWEQIPAAELGGEGFVDFDITQWYYPANAKVDVAQLVEPYRNDCIFHDASGACHFFFKEVGNWTVSSIALPSNLANPPIDYFLDSSSTVIQRILPAIREHGISWSWLLQLIARTWMNTLKIASQASKTELLIVGTAYACMLISIVSLYLKMRRLGSKFWLFFSVLLSTLFSVQFAMTLVRASGVRISLVSLIESLPFLINVVALDKAAELTRQVITRCSVSDSHSPMHEDIAKACRNAAPPILRHFSFGIVVLAIFSYCNFGIKQFFLFAAVMIYDLLLLFSFFVAILTLKLEMRRYNAKDDVRKVLIEEGLSESTARHVADGNDSSATTSAGSRYFKVRYGTKIILFIFIAFNLFELCSIPFKHYAATSAAAARLIPLVRSQYPDFKSQRLLDDGVFDDVLSAISSMSNIESPSVRLLPAVFYGAELSSTSFLSTIHSFINNWSHYISASFLSKWIVCALSLSIAVNVFLLNAARLNSIKEEPEKKVVEKVVEVVKYIPSSNSSSIDDIQKDEIAQESVVRSLEECITLYNNGQISTLNDEEVVQLTLAKKIPLYALERVLKDVTRAVVIRRTVVSRSSRTKTLESSNCPVYHYDYSRVLNACCENVIGYMPLPLGVAGPLIIDGKPFYIPMATTEGALVASTMRGCKAINAGGGAVTVLTRDQMSRGPCVAFPNLTRAGRAKIWLDSPEGQEVMKKAFNSTSRFARLQHIKTALAGTRLFIRFCTSTGDAMGMNMISKGVEHALVVMSNDAGFDDMQVISVSGNYCTDKKPAAINWIDGRGKSVIAEAIIPGDAVKSVLKTTVEDLVKLNVDKNLIGSAMAGSVGGFNAHAANIVTAVYLATGQDPAQNVESSNCITLMDNVDGNLQLSVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGAHMTSPGDNSRQLARVVAAAVMAGELSLCSALASGHLVKSHIGLNRSALNTPAMDSSAKKPATDALKSVNSRVPGR
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Sequence:
MGDAIDLSGDGGVLKKIVRSAKPDAISPSDDLPVVDVHYEGILAEDEKVFDTTREDNLVFSFELGTGSVIRSWDIALKTMKVGEVAKITCKPEYAYGRAGSPPDIPPDATLIFEVELVACRPRKGASVGSVSEERARLEDLKKQREIAAAAKEDDKKKREEAKAAAAARIQAKLDAKKGPGKGKGKGKAK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGPVSHGYLPRMCHMHERMSYVLPIDGFCLTVIFPGCAICMRQMSYVLLIDGLCLGYLPRMCHMYETDELCAPHRWVIYLTVICPGCAICMREMSYVLPINEDRPEDLQIPSIGKSIGCLKKKLLVLDVNGLLADIVSHPYPKNIKRDAMIAKKAVYKRPFCSEFLNFCFENFDVAVWSSRIEKNVNRFLNYLMGDLKERLIFCWSISQCTVTNISTLEDKRKTVVFKDLRKIWDKYDPNLPWEKGYYNESNTLLLDDSPYKGLLNPPYNSIFPHSFTYRKKKDKSLGVGGELRQYLEKLAKVEDMVKYVEKHPHGQKRISETNESWDFYLKILSLVEPKE
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRGEGGVLAMALASRGIVLLAMLAWAWLGSPYDSSAALDLPCLSRDDHGFDRGGISNSTLLRSVVWDGVYYLRIARCGYEYEQMHAFQPLLPLLMRFLSNTALRGFVPVFGYDETLALSGYVINVMAFVLAALYLYRLSLYVLERERMAFLATAFFCFNPASVFYSSLYTESLFALLSFAGMWYLVSGARWKSAILFGFSSIARSNGIVHAGFFLFQCLHLVYHNKVFHMKRPLLAGSLFVIIQCGLQASLVVAPFVVFQAYGYFEMCFNDSKQQRPWCKATIPYLYGFVQDHYWDVGFLRYFQLKQIPNFLSASPALLLASSAIVTYARAQPKLFYSLGLAAPSWQKRKAALLPDHSKPPRVKKEATGFYAVASVPFVFELLVMTLVAFLVMHVQVSTRFLSCSPVIYWFSASFRRQWIGWWVFLSYTLVGTLLFVNFYPFT
The following text describes a protein:
Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
Sequence:
MPPLWVVLALGCLRLGSGVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSSAALHGTYEVYLYVLVDSASFRNASVQDSTKTPLSSTFQQTQGGRTGPYKAAAFDLTPCSDSPSLDAVRDVSRASEILNAYLIRVGTNGTCLLDPNFQGLCNPPLSAATEYRFKYVLVNMSSGLVQDQTLWSDPIRTDRLTLYSAIDTWPGRRSGGMIVITSILGSLPFFLLIGFAGAIVLSLVDRGDADGATSHDSQITQEAVPKSLGTSEPSYTSVNRGPSLDRAEVYASKLQD
The following text describes a protein:
Function:
Controls the tethering of the proton ATPase AHA1 to the plasma membrane. Is essential for stomatal opening in response to low concentration of carbon dioxide and light.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Translocates reversibly between the cytoplasm and the plasma membrane depending on environmental conditions.
Sequence:
MEEENAVEILQRYRRDRRKLLDFMLAGSLIKKVIMPPGAVTLDDVDLDQVSVDYVINCAKKGGMLELAEAIRDYHDHIGLPYMNSVGTADEFFLATIPESSGSPPKRAPPPIPVLISSSSPMVTNPEWCESPSAPPLMRSESFDSPKAQELTVDDIDDFEDDDDLDEVGNFRISRRTANDAADLVPRLPSFATGITDDDLRETAFEILLACAGASGGLIVPSKEKKKEKSRSRLIKKLGRKSESVSQSQSSSGLVSLLEMMRGQMEISEAMDIRTRQGLLNALAGKVGKRMDSLLVPLELLCCVSRTEFSDKKAYLRWQKRQLNMLAEGLINNPVVGFGESGRKATDLKSLLLRIEESESLPSSAGEVQRAECLKSLREVAISLAERPARGDLTGEVCHWADGYHLNVRLYEKLLLCVFDILNDGKLTEEVEEILELLKSTWRVLGITETIHYTCYAWVLFRQYVITSERGLLRHAIQQLKKIPLKEQRGPQERLHLKTLKCRVDNEEISFLESFLSPIRSWADKQLGDYHLHFAEGSLVMEDTVTVAMITWRLLLEESDRAMHSNSSDREQIESYVLSSIKNTFTRMSLAIDRSDRNNEHHLALLAEETKKLMKKDSTIFMPILSQRHPQAIAFSASLIHKLYGNKLKPFLDGAEHLTEDAVSVFPAADSLEQYLLELMTSVCGEDTSGPYFKKLIPYEVESLSGTLVLRWINSQLGRILSWVERAYKQEHWDPISPQQRYGSSIVEVFRIVEETVDQFFALKVPMRSIELSALFRGIDNAFQVYTNHVMEKLASKDDLVPPVPVLTRYKKETAIKVFVKKELFDSKHLDERRSINIDVPATAMLCVQLNTLHYAVSQLSKLEDSMWLRWIAKKPREKIVIRKSMVEKSKSFNQKESFEGSRKDINAALDRICEFTGTKIIFCDLREPFIENLYKPNVSQSRLEGLIEALDTELGQLCSVIMEPLRDRIVTSLLQASLDGLLRVLLDGGASRVFHPSESKLLEEDVEVLKEFFISGGDGLPRGVVENQVARVRLVVKLHGYETRELIDDLRSRSSLEMQQGGKGKLGADTQTLVRVLCHRNDSEASQFLKKQYKIPRSHG
The following text describes a protein:
Function:
Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.
Subcellular Localization:
Nucleus.
Sequence:
MGDQQLYKTNHVAHGSENLFYQQPPLGVHSGLNHNYGNAVTGGGMDAPQASPISPHFPQDTRDGLGLPVGSKNLGQMDTSRQGGWGSHAGPGNHVQLRGNLANSNMMWGAPAQAEPTDGYQYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSALRQLLSQKPMEPPAPAIPSRYQQVPQQPHPGFTGGLSKPALQVGQHPTQGHLYYDYQQPLAQVPVQGGQPLQAPQMLSQHMQQMQQHQYYPPQQQQQAGQQRISMQEIQTQPQQIRPSQPQPPPQQQQPQQLQLQQRQGSMQIPQYYQPQPMMQHLQEQQQQQMHLQPPSYHRDPHQYTPEQAHTVQLIPLGSMSQYYYQEPQQPYSHPLYQQSHLSQHQQREDSQLKTYSSDRQAQAMLSSHGDLGPPDTGMGDPASSDLTRVSSTLPHRPLLSPSGIHLNNMGPQHQQLSPSAMWPQMHLPDGRAQPGSPESSGQPKGAFGEQFDAKNKLTCSICLKEFKNLPALNGHMRSHGGMRASPNLKQEEGEKVLPPQPQPPLPPPPPPPPPPQLPPEAESLTPMVMPVSVPVKLLPPKPSSQGFTNSTVAAPSARDKPASSMSDDEMPVLEIPRKHQPSVPKAEEPLKTVQEKKKFRHRPEPLFIPPPPSYNPNPAASYSGATLYQSQLRSPRVLGDHLLLDPTHELPPYTPPPMLSPVRQGSGLFSNVLISGHGPGAHPQLPLTPLTPTPRVLLCRSNSIDGSNVTVTPGPGEQTVDVEPRINIGLRFQAEIPELQDISALAQDTHKATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFEAKGDVMVALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCVTSEEEEELEEEEEEDPEEDRKSTKEEESEVPKSPEPPPVPVLAPTEGPPLQALGQPSGSFICEMPNCGAVFSSRQALNGHARIHGGTNQVTKARGAIPSGKQKPGGTQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGAPGLLPLDQLSLIKPIKDVDILDDDVVQQLGGVMEEAEVVDTDLLLDDQDSVLLQGDAEL
The following text describes a protein:
Function:
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Utilizes a two-step reaction via a ping-pong mechanism. Lnt undergoes covalent modification in the presence of phospholipids, resulting in a thioester acyl-enzyme intermediate. It then transfers the acyl chain to the amine group of the N-terminal diacylglyceryl-modified cysteine of apolipoprotein, leading to the formation of mature triacylated lipoprotein. In vitro, can utilize the phospholipids phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidic acid (PA) or cardiolipin (CL). PE is the most efficient acyl donor.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAFASLIERQRIRLLLALLFGACGTLAFSPYDVWPAAIISLMGLQALTFNRRPLQSAAIGFCWGFGLFGSGINWVYVSIATFGGMPGPVNIFLVVLLAAYLSLYTGLFAGVLSRLWPKTTWLRVAIAAPALWQVTEFLRGWVLTGFPWLQFGYSQIDGPLKGLAPIMGVEAINFLLMMVSGLLALALVKRNWRPLVVAVVLFALPFPLRYIQWFTPQPEKTIQVSMVQGDIPQSLKWDEGQLLNTLKIYYNATAPLMGKSSLIIWPESAITDLEINQQPFLKALDGELRDKGSSLVTGIVDARLNKQNRYDTYNTIITLGKGAPYSYESADRYNKNHLVPFGEFVPLESILRPLAPFFDLPMSSFSRGPYIQPPLSANGIELTAAICYEIILGEQVRDNFRPDTDYLLTISNDAWFGKSIGPWQHFQMARMRALELARPLLRSTNNGITAVIGPQGEIQAMIPQFTREVLTTNVTPTTGLTPYARTGNWPLWVLTALFGFAAVLMSLRQRRK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, UBC28, UBC29, UBC30, UBC35 and UBC36 in vitro.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MSSNDRDHRRFNSDHHSFWPNPSTYDLNSKIMLAAVASLSGVILIVFALHLYARFVLRRRREAFRGLPVIFRHPFEMPKRGLNPTVIASLPTFTVGATDGVAASATECAVCLSVLKEQDKARELPNCKHIFHVDCVDTWLTTCSTCPVCRTEVEPRPRLEPEPREGPVGTAPQLLVETRLNLTVEAASSSSSDNKTVVSPASRLNSFRKILTRERSSNRINHSCPDQDRVADLERH
The following text describes a protein:
Function:
Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKIKSIYGIHAVSGVLDAAPQRIVKLYVQENRDDQRLQSLVEKAKALGVKVILLSRTELNTLSNEKHQGIVADCEEVENLDESALLSLLKKRETPALLLILDGVKDPHNLGACLRSANAFGVRAVIAPKDRAVGVTPVVRKVACGAAEMTPFIRVTNLSRTIDWLQKEGVWIVGTAVEAETLIQEIDLTGDIAIVLGSEGAGLRRLTKERCDFLAQIPLRGSVESLNVSVACGICLYEVQRQREAPAPS
The following text describes a protein:
Function:
Required for the Mettl1-dependent formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity). In the Mettl1-wuho methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (By similarity). Required for binding of nanos mRNA and repression of translation by the mei-P26-bgcn-bam-sxl complex. May cooperate with mei-P26 and nanos to derepress the BMP signaling pathway. May cooperate with mei-P26 to suppress expression of a subset of microRNAs. May cooperate with mei-P26 to regulate bam expression levels in germline cells during gametogenesis. Required to promote mitosis to meiosis transition during gametogenesis. May regulate germline cell division in part by regulating ribosome biogenesis (By similarity).
Miscellaneous:
MISCELLANEOUS: Wuho means 'no progeny' in Chinese.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized to the nuclei of nurse cells, follicle cells and oocytes at early stages, from germarium to stage 4 egg chambers. Also present in the nuclei of spermatocytes and in the apical cells of the testes. In the cytoplasm of all germline and somatic cells of the ovary.
Sequence:
MCTTISFAEPEIVLGHGRRVLFVNPDDLQIFKEIELPPDLGLKCHETQSQESCPATATSTTAGKEPGGKEQQLAKQPEEGGTSASGSVATSTSVQNVAYSPDGQLLAVTTSGGQKALLLYRSRPENARLLSARPLARAASAVRFCSDSSSVLVTDKTGDCYQYDCVEVEAPPRLLLGHLSVVYDILWSEDQQHIITCDRDDKIRVTNYPATFDIHSYCLGHREFVSGLALLTEQHIASASGDKTLRVWNYIQGKELLQHELPAPAVRLLVRQLEPEKVFQAAVLFYEHVDALGLYRLERSSDDTWSVTATQLVCAEAGSWSISNFTLTSDRIYITGAENERLSLRVYDIATGQPTTNGVPEGWLKMVLDGLGANEEGAPPFIPEDLSVWFKKRFDNVTDYLERKKRRIEEQKQQKC
The following text describes a protein:
Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MSHSSGIELSTDLINKFKDMNSSGNGRFIQATIVDETINIKAIEQGTSDFDADLDLVLKYLVEGEPSYILFRTETRDDITNGYKWLLLAYIPDRAKVRMKMLYSSTKARFRTTLGGSTFLYEIHGTVFSDFGKSGYEAFLRHEMSAPPLTEEEEEREKEIELGVSGLGAVPTGMATVTASNGVAFPVDEEVINAVKELCDGGNNYVQIGIDIDSERIVLQAQKSVEIDHLGEEVPLTLPAFHFYRWDHEYEGQQMSKIIYIFSCPDGSGNTKSAPVKQRMLYSTSKGAVESVLTGNGKEVDLKLEINAPKDLSVNDIQDKIHPPPVQEKKMFARPKPKFCRKK
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
Sequence:
MVTTIVIACTFRAGTTHHSWCAAVALRAGSFAADDKSLLARFYHADRALTAIASELDSFDGRAEPVRCTRLVSRLRQGQDRVLAITNQIMDELLGDDRAQRAFRVKFPEEVLQESLAGQLWFGAECLAAGSSILNREAESAKMRPLAKAVTKSLEIVRNRLREQCLRNNTPNSPTLRLDINDAATEQLYESLKIFDRLFAEFELVYVSAMVQVKTKQEYEMQELICVLFSETLQRALKTGLLEQEQVDSYDPALMFSIPRLAIIAGLVIFREGPLNMDQPADNISEMFRPFRKLLIKMRDLLHALTKQELYQLEKLLCTNEEISASEQLICDEKGRSGGDGGSGSGGTAAAGVKEFDALEPVGESQEHVVIVTTVTTTNAPNVVGDGPGATGCTDATSGADGRLHIVSQGYGVSTGATGSSGFGSGRGGCSSSSTSRPKQRHNQAHLRQRGAPRHSSQSFAPEASYAGDDREPVVEEDNNNHLRKEIEEEDVDDDMEEEEEDEEEDEVDDDAMLKDGLVTTDCASGYLIPNTNFGNLLQTNEAPLTDSFIATDDELRLLGAETASSPPAMTQANIDSILAASAAGSGGQQQQQQQQQLIDSDSGHGTANHSTDMSPELETERTVVAAGQPNANDAPLDGSVSKQQPVRDRSRSGSSTVHKHAEISESSSDYEEADVDDEPDDVDADDDDEEEDDVVGEVEEQNDSEPTFNRKVGGAPKEAFRSQLRCKAARNHRKSSHHRPRPSTSSSSSSAAYRNKSQSHQHHHHHHHHHHHSYAESAEGTSSVVSTITTSNNSTSNGSTRHHSRMQQQHQQHQQQRNSSSSCDTSPTQSECSDAQEVALAIRAAGRNKFKSTENLLHRLFVCIAGVADQLQTNFAADLRKMLRSVFIMNSSPPEPDEPPEPSGSEEESKDSQHNHPSDLFEFRASEQDVITADQQNHSGGSSQSIYSAEEANPEQDSVFGSSGDSSPVRRTASVESRNVTVNVSVSVVASSPVGAGGAGGGGMVGGSRTGQERSVSLSEACIVVEGGKASAGGGGGTRRHSASGSKNDYGRSRSSPSSPVNSNTGGGGGGNHHSSAHHTAHEQQRRMPEEPPRWIPDCDAPRCMACASAFTPFRRRHHCRNCGGVFCGVCSNLSKPLPKYGLTKAVRVCRDCYIHEVGV
The following text describes a protein:
Function:
Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Also seems to control expression of at least one other multidrug efflux operon.
Subcellular Localization:
Cytoplasm.
Sequence:
MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG
The following text describes a protein:
Function:
Probable cation transporter. May be involved in regulation of potassium-sodium homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
HKT transporters are proposed to contain 4 pore-forming regions enclosed by transmembrane segments with each containing a potassium channel-like selectivity filter motif.
Sequence:
MPIRLHIFVNSARHAINSSAFICRFIAYHLSPLLIHLSYFLIIDILGFVSLVVLRPSNHKYNPRYVDMFFLSTSAVTVIGLATIQMEDLSSSQIAILTLLMFLDSKMFLSFLGLVLESSKQNKHDPENRRVSSVTVCKQSQLEEATPQTPSMNSIDIKKRCLKYLVFVVLAYMIIILVTGSLLVFMYIAHVSSARDVLTRKSINKALFSISVTVSSFTNGGLLPTNESMVVFSSNNGLLLLLIGQILAGSTLFPVFLRLVIWALRGLRLAKAEEPDFMMNNSSAVGFSHLLPNLQTIFLAVVEVAFVAMTVILFCCLNWDSVVFAGLSSLQKITNALFMAVNARQAGENSIDCSLVAPAALVLFMVMMYTPSLTKLFSACQDHKRIGPESDDRTSKGKPFLKMMAFSPLGFNTTVIMLVCITERRSLSTDPLNLSTFNIIFEVISAYGNIGLSTGYSCSRQLQHQEGIACHEKAYNFSGWWSEPGKLILVLAMLCGRLNSKDSTSARTR
The following text describes a protein:
Function:
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the subdistal appendages of centrioles.
Sequence:
MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDSTNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAVRSRPQLAFQTEKENGIGITAFNETAKLYANVVEALDAQRLRIFDSVAGSLKTEYILEKEKVISCIAWEQKPLYASEQITTDISGSGEILVLGTNSGEILIYSEHLGSLTRTYSFGILQKIIGAHVLANDGFAIDITGKVVCFSVNTGEVRTSFTVPSSSREFSGLYLSTVFKNLALASSHNIHIVDLNHRNPIDSLTTHTSMINSVVFQYLKDENKFYFGVSANQDRFINLYSKELDGTGEFPTNTVKNVGALVCENEVKMLSIAYEIENPETGVLAALTNDGTIEMFENPWLSKLRQNGTNASSLSHRRKLLTSHSTLKICFCRSRGDPPIVLESIAFESTDSLTVVWKESTRTVFETVPWRILSSQATNGLIELVRSKTRLTSKNKTVSNVYDESNATISSGVMQKDLRKTEEIGSAEAMEGEEQEPSLAERLQNLTKLDQQAQALSTQISASTSLSTVLTQALKTNDQSLLESCFNNNNVETIDTTIRRLDPSLAPILLDKLAEKLALRPMRADVLMVWIRCTLITHGGHLVLVDDLKHKLANLHSILEDRASKYSSMLALQGKLDLVLSQIAFRKAGGSKDNAEDEEPISIYYEGYEESMDEASSTGDEGYSSDDSVDNEMYSDEENSSKGAFPDEENENRELSEDYSGDESLENSESE