lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MRVPSIYNFPPFFTRQLNDNTWHSQKAAWQMWILLWCRENRQTSITINPELLESSLLHNSTIHRTLPLSVFREIVEDMVKQNLAEWTEKRNPKDVFWVYWRSISEWGNMILKWLSDMGREGSICTFYELQEQYKEVDCLDEVLLHKVLELLMKKGNIELMKGSSGKYSGFKVLKA
The following text describes a protein:
Function:
Atypical and probable non DNA-binding bHLH transcription factor that acts as a positive regulator of cell elongation and plant development. Binds the transcription repressor IBH1 and forms a heterodimer of antagonistic bHLH transcription factors that function downstream of BZR1 to mediate brassinosteroid regulation of cell elongation and lamina inclination.
Miscellaneous:
MISCELLANEOUS: Gain-of-function mutants ili1-D (T-DNA tagging) show increased lamina joint inclination and hypersensitivity to brassinosteroid.
Sequence:
MSSSRRSRSRRAGSSVPSSSSSSRTSISEDQIAELLSKLQALLPESQARNGAHRGSAARVLQETCSYIRSLHQEVDNLSETLAQLLASPDVTSDQAAVIRSLLM
The following text describes a protein:
Function:
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNMGPLLLLSLLSLWGTAVRAEHGASTDGKSPAFCGERECPKFQLIQQYDSFELRAYEGSQWVTTELDDGFLGFGMVTSFRRLFNYISGKNSQEKKIEMTVPVLIQYPLKDTGRNATMSFFLSPSLVNPPKPLDPAVYLENTSPLSVYVMSFGGYALDYDYKKKAKALAEKLRNLGLSFDDSVRTTAGYNDPFTLINRHNEVWYKAK
The following text describes a protein:
Function:
Component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. JNM1 is associated with the rod and links it to the projecting sidearm. Required for proper nuclear migration during the mitotic cell cycle and for astral microtubule development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNVIDLSDPAINVDYDSLIGIDNEESQEIFENEVKEDGQQEEQEEASSRKDGLIVEPGRDVESLRRAIRDQLLFKIHRQNQSDCADARKLSNDEEDESRQQKLERIREELEELKIENLTSEMQTEIKELCEIQSKLATESSSRLTNLRKKLLETYEGQDTVILPNIILDTSNIKRLQKLDQKISLMERFVGIPEALEAEEDRKSVHSKVNELYRSIQLLQGDDKAEGKLQKFRDRLVELNEEFENSLLGKKIQQDLRLKDDTVSKLVMPENKVKEINSMYSMFKQYQDSLPLLAERMKSLNKMNNRVIEVYETTKGLDSQITSIQEQGKVWLKALNELDKKFDEQEVKIRENMEQIRRKIDTLEDEALQRNSK
The following text describes a protein:
Function:
Involved in translational repression of multiple mRNAs in the distal gonad. Recruited to the 3' untranslated region (UTR) of zif-1 by oma-1 and is required for translational repression of zif-1. May also be involved in translational repression of mei-1 through recruitment to the mei-1 3' UTR by oma-1. Required for oogenesis but not spermatogenesis, for P granule formation and for the localization of car-1 and cgh-1 to P granules. Required for normal spindle orientation in early embryos.
Subcellular Localization:
Cytoplasm. Note=In one-cell embryos, expressed highly and diffusely throughout the cytoplasm and is associated with P granules.
Sequence:
MTSHLDDEGLHPMVSTLLGGGTLPTVPFKAYTRERMMELRTTKASMTRPENLSEDFNGEDGKFSPLKWLEHRWEIEGIKNRPMSKKIDSLCAGADENTGLSPQRRAFSSGCKAPTDDKGRDGEYERLGGHGKNWRNGSTGGADKFASRGNDFKPSFQKGNQLERGTRGAEWKKDTTRGAKFAPRREERLTSLSGSEKLPEWADGPTTMDDMIELRGFDEPKKVKNKKNPKEKKEKEAVKAPEPVECVGSRPSSTGLKTSEPIDDPAIAYSSSGGGALPATDQELAALLGCLDIQKTSRKIDGDDMAWAHKSEETAGGTSRLSRFFAKKNKSPELDAMLSSVGGGNDENVANPMLARLFGHSGGDNNASSSGAGDIKGGMRLEDLEKGMESKEPSKVSPLQDPSQQAQLLQHLQKFAKQQAESGQHIHHHRQPTPPNGGPQHQQHLHHPMVHPGMQIIADPSLLASFAQNPVILNAYVENQLQEAVNAAIRANNGQQLPPQLHEQLRMASMRNKAFLQSQTLTFVSLQQQHQNIQQHQQQQQHHQHKGRTPAMIPASVQRQLQKSSSNADQKKEKTSQSPPESNQETSDAHNQSDAMNQLKKLHMQQNYANMVQAMNSGVGWARGNGVVNGQQQHPQQQLPPNVQMLMAQHQQAQMQHLKMMMSRAQQQHMLMAKIAQMQQQQAQMANMQERQGPSHNQQQHQPVVPSELSQVGPIQTPLEKLLASVGVQGSQFTGSGDRIPSSVRPMSLEDLEKQLTAVPK
The following text describes a protein:
Function:
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC, two subunits of the NQR complex.
Subcellular Localization:
Cell inner membrane; Lipid-anchor; Periplasmic side.
Sequence:
MEISFTRVALLAAALFFVGCDQKPQPAKTHATEVTVLEGKTMGTFWRASIPGIDAKRSAELKEKIQTQLDADDQLLSTYKKDSALMRFNDSQSLSPWPVSEAMADIVTTSLRIGAKTDGAMDITVGPLVNLWGFGPEQQPVQIPSQEQIDAMKAKTGLQHLTVINQSHQQYLQKDLPDLYVDLSTVGEGYAADHLARLMEQEGISRYLVSVGGALNSRGMNGEGLPWRVAIQKPTDKENAVQAVVDINGHGISTSGSYRNYYELDGKRLSHVIDPQTGRPIEHNLVSVTVIAPTALEADAWDTGLMVLGPEKAKEVVRREGLAVYMITKEGDSFKTWMSPQFKSFLVSEKN
The following text describes a protein:
Function:
Probable glycylase which modifies tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of tubulin.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Note=Mainly present in assembling locomotory cilia.
Sequence:
MSSLDEGLKQMSQQEYRNEEQNQEGNQEDLNNQNDHNLNNNELDSLSSPPSDNYNEEEFEQEDDIKPDIKIYQNASQNNISQTQRISQTQLPQQQGGGGKRNSSLLQKEHYHQKNQEIIQKLMEKKKKEQEEKEKKELKLKKREDKLRKRMLEEAAKIREQKEVNLESQTEQSDHSNVTKSKKLKFKSVQDIYQLVVIQGKYQREQLTDKQQQELNEFESRLNEEKTTIIKMQQVYRSRQITFLEELKKKQEKKKQEEEQQKLKQEKIQTKLREQYENVNSNLYAETELFKQKKQEITKVSTQKQLVRASSAEGDKEKDDKKDIAKKIQQKNQEYIEKLKEKKRQEIAKEEEEKKKKEQLKEKMKDFVLVNIKKDIENGVFFVDVPEKKPKKEKKKNESKEDNIQITSPKLNSTKSLSSQITRKTNDAKKVEKLPKIKDSNKENHSKERNEDNEEGDDGEYECDEGDEGASDGEDEDDGNGSAIKRKLRKYPFITDLELWKKKQRLPADIKVFIVTGGYHDISKALKKRGWIANPDTKSPCYNFRWSLQTKDIDYENLKDFQIVNHFQKSACITTKVGLCKSLRNLVWHENVDIDTFYPRCFDLNDTEDFENFVEEFKSSKAESILKRYMRMYFEKDPDIEKIKKQAVIAFNVCERKMKELDEIIDDPNSIQLITKKEWNILSADELTEEKLAQKKYEQWLERIEGKNKQKPKKKKKKSKKDKQQGDTEKKEEEEGEAEDEEEDEEDEEEEEKQMDEFTLKVHQILKRYKVKYPQDCLTGEDNVWIIKPAGLSRGRGITCYNNLVEILDHVKSKESQWVIQKYIENPLIIKKRKFDIRVWILVTDWNPLTIWHYTDCYVRFSVDDYDTENLQNKFTHLTNNMVSKLKQRDEKDDITELGSMYFKENFINYLKEKEGYDVFTDKIEPQIVRAIIMSLKSVQDNIENRKNSIEMYGYDFMVDDLYNTWLIEINSSPSMEYSTPVTERLVKAVSEDIVKVVIDYGMEKSKKARKNIETGAFKRIYKGKYVEEKTNVVGLNLICEGVALKKGKKNSNVAKVNNLKPNFS
The following text describes a protein:
Function:
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKDSSKLLKTKTEAPTTMTYPLKATSTVKQSWDWTTDMDGYLGETSAGPGKSLPVFAIILIISLCCMVVFTMAYIMLCRKTSQQEHVYEAARAHAREANDSGETMRVAIFASGCSSDEPTSQNLGNNYSDEPCIGQEYQIIAQINGNYARLLDTVPLDYEFLATEGKSVC
The following text describes a protein:
Function:
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.
Sequence:
MEGKPKFLHGTLEATIFHATPYSPPFLLNCINPAGKPTYVTIKINHKKIASTSHESSRIWNQTIRVLCAHSINTTITITLKTKCSILGKVNIQADRLLQESSLIDGLFPVCMENGKPNPELELRLMLWFKPANLEPNWRKIIDKNVFHGVKDATFPLRGKCGVTLYQDSHHHPTFKPPCGSPRKLWEDVFVAIENAKYLIYIAGWSFNPKMILVRDSETEIPHAKGVSLGEILKRKAEEGVSVRIMIWDDETSLPFIKNKGVMRTHDEDAFAYFKNTKVVCKLCPRLAHNFPTLFTHHQKTITMDTRGHSSSSKREITSFIGGIDLCDGRYDTEKHSIFQKSNTDFYQTSISGAQVDRGGPREPWHDAHACIIGEAAWDIMRNFEQRWVKQFDPSLLIPVNKITDLGRESVTITERNWNVQVFRSIDHVSVCHVAKNFTIEQSIHNAYVEAIRRAERFIYIENQYFIGGCDLWEKEKDQHSGCRNLIPIEIALKVVSKIKAKERFAVYILIPMWPEGVPESEPVQDILYWTRETMKMMYGLIGDAIRDSGEGYHPKDYLNFFCLGNREVEKEGEYIPRYSPHHGTQYWNAQKHRRFMVYVHAKLMIVDDSYMLIGSANINQRSMDGTRDTEIAVGCYQSKDENVEKTDKRDVHGYRMSLWYEHTGRVEQVFQDPESLECVVMMRLFGERMWEIYSGDEVIDMEGAHLISYPVSITREGEVEDYVDSGGCFPDTKAQVKGRRSKVLPPIFTT
The following text describes a protein:
Function:
RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein. Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs.
Subcellular Localization:
Chromosome.
Sequence:
MEAAPGTPPPPPSASPPPPSPPPPSAPSPPPCSPDACPAAPHLLHHRLPLPDDRSGPRPGRGSVPGGRRRRRRRRRKGGAAMLGRAAAAAEEEEEGRGRWVSLARSLFLARFLSRPHASPPPRGARPLSLALALSFLGAMLRGREDGELEEGELEDDGAEETQDTSGGPERSRKEKGDKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHTTSLPKKGYSKMDSKGYGMYEDYENEQYGEYEGDEEEDLGKEDYDDFTKELNQYRRAKEGSSRARGSRGRGRGYRGRGSRGGSRGRGMGRGGRGRGRGSVGGDHPEDEDDFYEEEMEYGEGEEPMGDEDYDDYSKELNQYRRSKDGRGRGLSRGRGRGSRGRGKGMGRGRGRGGSRGGLTKGGMNDDEDFYDDDMGDSGGSYRRSDHDKFHQQSDKKGKAICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPPPPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPMPVHEPLSPQQLQQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYQQQEGMEMEPGLIGDTEDYGHYEELPGEPGEHLFPEHPLEPDSFSEGGPPGRPKPGAGVPDFLPSAQRALYLRIQQKQQEEEERARRLAESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPQASVGELSSSGLGDPRLQKGHPPGGRLADPRLSRDPRLTRHAEASSGSGPGDTGPSDPRLARSLPTSKPDGGLHSSPVGPGSCKGSGPPPAEEEEGERALREKAVNIPLDPLPGHPLRDPRSQLQQFSHIKKDVTLSKPSFARTVLWNPEDLIPLPIPKQDSVPPVPAALQSMPALDPRLHRAAAPGPPNPRQRPGTSTDPGTSGSNLPDFELLSRILKTVNATGPSAAPCPSDKPSDPRVRKAPADPRLQKPADSAASSRAAKPGPTEAPSPSGSPSGESSPPATAPYDPRVLAAGGLGQGSGSGQSSVLSGISLYDPRTPNAGGKASEPAADSGAQPKGTEGNGKSSAAKAKEPPFVRKSALEQPELGKASADGGAATATDRYNSYNRPRPKASAAPAATGTPPPEGAPPQPGVHNLPVPTLFGTVKQAPKTGSGSPFAGNSPAREGEQDAGSLKDVFKGFDPTASPFCQ
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MFCAISGKPPITPVVSPESKCVFEKRLIEQYIDEHGVDPISKTSLTKDALIVIAQTPQQYALANAVNSATLNANYSIPNLLSTLQNEWDAVMLETFELRSQLDMCKKELSSALYKCDAAIRVAARAKQESDELRHTLTELTEAVGGQAADAPPLPAELITAMAEDAQEYVQQTKERRKMKSQVVTAFALEQPVETACEVDRVFVNRLLDPEDRVTCILARGKARLLNREGVLLLDDLPAELKIVFPVDRSGVVFSTDSQMGIYETSTKEFKIFGSPTSSRIVDIQYSPFVAAEFLVTLNENHEIHYRNRDGSQIYRFVNGKVHFPDAGEPAQLQLHKDGLLIAYQPTFSTIAIFSVTAPKDPPIVIMPSSSTEESTGELVTFRFSPNGYWLYVLTELAFLVYDLRKQPGTLAMNPLMLNSPAVAFDTDQTGKTLFLLSADGSLESYSYVKSQNGWSRGICHSSDRLAPLDLVYLADKAGVFLQGFHALTDDQTDRYIPAWLRIE
The following text describes a protein:
Function:
May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRPRTKARSPGRAPWNPWRGFLPLTLAFFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDASVADLPPVERAQLGWGIPRRPTETEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRARAAPALPRLGIPRRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCQPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRVAPRRWAERSPNLRRSSAAGDGTLARAQPPAPQLPSAPQSPPVPQSPPAGTLSDLSQTHPSQQHVGLSRTVRLHPTATVSSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRSRALLEAPLRHSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVARVRGGVEEALEENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPDTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPADRQPLRVITDTWLEAGTIPDKGDSQAGQVTTSVTHTPAWVTGNATTPPMPEQGIPEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNICGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCRGKGRCINRVGSYSCFCYPGYTLATSEATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECANRASCPTGLCLNTEGSFTCSACESGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQGSCLGGECKNTAGSYQCLCPQGFQLANGTLCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCLDVDECAATDPCLGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGAWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECTNDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSIPEAPTGDHAPAPTRMDCYSGQNGHAPCSSVLGQNTTQAECCCTQGASWGEACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHRKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDVCWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHPGDRTPILESPLQPSELQPHYVASHPEAPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE
The following text describes a protein:
Function:
Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1; Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MAAESLLSGLLRLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQASDVVIVSSKYKQRYECRLPAGAIHFQREREEEAPAYRGPGIPELLSPMKDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTVRTPRLCPHPLLRPPPSAAPQAILCHPALQPEEYMAYIQRQAVDSKQYGDKALEELQDLEPQTWGEAQPRAVPSKRGGAHPTKDDSKESDFWKMLPEPQEQTPGATEMPAEEQEPNLEAADPAPAPPHDFQNNVQVKVIRSPADLIRLIEELKGGTKKGKPNGGQEQPVGEAAEVPQREAEEKDKSDMDHQNEVEEEEEEEEDEDEDEDEQQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELETIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHRKRRVAPKKPPPSPPPAEEDPEHRVRVRVTKLRHGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAEGKIEIKIVRPGAEGAEEDSHWLTDEDTRNLKEIFFNILVQGAEEAQKERQRQKDLESNYRRVWGSRGAEGTGDLDEFDF
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Sequence:
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ
The following text describes a protein:
Function:
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
Sequence:
MATLDVNPELYQAQLADKIARLKAMFVDYSMPELEVFESPVANYRMRAEFRIWHEGDDMYYIMFNQETREKYRVDQFPAASRLINDLMPLLMDAMKGSPILRHKLFQVDFLSTLSGEILVSLLYHRQLSEEWITAAQALKQRLNDEGFNLNLIGRARKMKVVLDRDYVVENLQVNGQPYVYKQVENSFTQPNAKVAEKMLEWAVDCTQESKGDLLELYCGNGNFSLALAQNFERVLATELAKPSVEAAQFNIAANQIGNVQIIRMSAEEFTQAMEGKREFNRLKDAGVDLQSYRCNTIFVDPPRSGMDIDTCKMVQGYERILYISCNPETLQENLQVLGETHQVVRFALFDQFPYTHHMEAGVMLERKK
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MLFSTVLSHRTLYILTCPNTLIHSYTHPHIHAYLAFTGFLTQLHHLEISCLLLLFFSLSSLLKLMADPDCIFRNGYVDYYNYSFNYATSLSRIYNSHDSFYYPHQTTNPNINENPNLTSPDSPPLREALPLLSLSPIHKHQEPTANHHEYYFMETTETSSNSNFLDQCQDSYRHDVTVDLHLGLPNLGDGGSSSSDVVLDSTDHQEGHHDHHQDQGLEVTMASDHDDEHGGLQRGNHLHHFWIPTPSQILMGPTQFSCPLCFKTFNRYNNMQMHMWGHGSQYRKGPESLRGTQPTAMLKLPCYCCAPGCKNNIDHPRARPLKDFRTLQTHYKRKHGVRPFACRRCGKAFAVKGDWRTHEKNCGKLWYCSCGSDFKHKRSLKDHVKAFGNGHVPCCGIDHEEEEAASDVEQQE
The following text describes a protein:
Function:
Serine protease required during eye development.
Sequence:
MLLAVLLLLPLPSSWFAHGHPLYTRLPPSTLQVLSAQGTQALQAAQRSAQWAINRVAMEIQHRSHECRGSGRPRPQAPLQDPPEPGPCGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCFVGAPNELLWTVTLAEGSRGEQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPVSPGGSARPVCLPQEPQEPPAGTACAIAGWGALFEDGPEAEAVREARVPLLSTDTCRRALGPGLRPSTMLCAGYLAGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVAVFKDWLQEQMSASSSREPSCRELLAWDPPQELQADAARLCAFYARLCPGSQGACARLAHQQCLQRRRRCELRSLAHTLLGLLRNAQELLGPRPGLRRLAPALARPAPALRESPLHPARELRLHSGSRAAGTRFPKRRPEPRGEANGCPGLEPLRQKLAALQGAHAWILQVPSEHLAMNFHEVLADLGSKTLTGLFRAWVRAGLGGRHVAFSGLVGLEPATLARSLPRLLVQALQAFRVAALAEGEPEGPWMDVGQGPRLERKGHHPLNPQVPPARQP
The following text describes a protein:
Function:
Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=In neurons, localized to neurites.
Sequence:
MQSFRERCGFHGKQQNYPQTSQETSRLENYRQPGQAGLSCDRQRLLAKDYYSPQPYTGYEGGTGTPSGTVATAAADKYHRGSKSLQGRPAFPSYVQDSSPYPGRYSGEEGLQTWGGPQPPPPQPQPLPGAVSKYEENLMKKTVVPPPNRQYPEQGPQLPFRTHSLHVPPPQPQQPLAYPKLQRQKPQNDLASPLPFPQGSHFPQHSQSFPTSSTYAPTVQGGGQGAHSYKSCTAPSAQPHDRPMSANANLAPGQRVQNLHAYQPGRLGYEQQQQALQGRHHTQETLHYQNLAKYQHYGQQGQGYCPPDTAVRTPEQYYQTFSPSSSHSPARSVGRSPSYSSTPSPLMPNLENFPYSQQPLSTGAFPTGITDHSHFMPLLNPSPTDAASSVDPQAGNCKPLQKEKLPDNLLSDLSLQSLTALTSQVENISNTVQQLLLSKATMPQKKGVKNLVSRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQDTDYLSGSEDPLERSFLYCSQARGSPARVNSNSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHSTLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIVEKADKAWAEASSLPKDNGKPPFSLENHGACLDTVAKTSWSQPGEPETLPEPLQLDKGGSTKDFSPGLFEDPSVAFATTDPKKTSSPLSFGTKPLLGTATPDPTTAAFDCFPDTPTASSVDGANPFAWPEENLGDACPRWGLHPGELTKGLEQGAKASDGVGKADAHEASACMGFQEDHAIGKPAAALSGDFKQQEAEGVKEEVGGLLQCPEVAKANQWLEESRHCCSSTDFGDLPLLPPPGRKEDLEAEEEYSSLCELLGSPEQRPSLQDPLSPKAPLMCTKEEAEEALDTKAGWVSPCHLSGEPAVLLGPSVGAQSKVQSWFESSLSHMKPGEEGPEMERAPGSSGTSQGSLAPKPNKPAVPEGPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRVPALPKDLLLPESCTGPPQGQAEGAGAPGRGLSEGLPRMCTRSLTALSEPQTPGPPGLTTTPTPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKEPDSPSMPGKDQRSMVLRSRTKPQQVFHAKRRRPSESRIPDCRATKKLPANNHLPTAYKVSSGPQKEGRMNQRVKVPKPGTGNKLSDRPLHTLKRKSAFMAPVPAKKRSLILRSNNGSGGDGREERAESSPGLLRRMASPQRARPRGSGEPPPPPPLEPPAACMGLSTQSSLPSAVRTKVLPPRKGRGLKLEAIVQKITSPGLKKLACRVAGAPPGTPRSPALPERRPGGSPAGAEEGLGGMGQMLPAASGADPLCRNPASRSLKGKLLNSKKLSSAADCPKAEAFMSPETLPSLGTARAPKKRSRKGRTGTLGPSKGPLEKRPCPGQPLLLAPHDRASSTQGGGEDNSSGGGKKPKTEELGPASQPPEGRPCQPQTRAQKQPGQASYSSYSKRKRLSRGRGKTAHASPCKGRATRRRQQQVLPLDPAEPEIRLKYISSCKRLRADSRTPAFSPFVRVEKRDAYTTICTVVNSPGDEPKPHWKPSSSAASSSTSSSSLEPAGASLTTFPGGSVLQQRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKARLEGTLEEASLPLERTLKGLECSASTTAAAPTTATITTPTALGRLSRPDGPADPAKQGPLRTSARGLSRRLQSCYCCDGQGDGGEEVAQADKSRKHECSKEAPTEPGGDTQEHWVHEACAVWTSGVYLVAGKLFGLQEAMKVAVDMPCTSCHEPGATISCSYKGCIHTYHYPCANDTGCTFIEENFTLKCPKHKRLPL
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MLRGHDSLTRLIGKRRRLSLSAISPNKRALCVSKNQVEEFSLLGSTVGSVKEESVEIRCSSSSSVNHQQVTEAETLLDGASSKKSLVKVKVECVEFRCSSSFSTKHQQGTEVEGLVDAAKSKEYLQKVKQERVEYHSVNQEQGTEAESLVDAESTKSNLLKVKQEVVKVEAEVNGELTQCPTCSKTVSGGLASNTHQDFCRQGGASEGKQKIKQSILSRFFSPGVNKLSSAPSSSRVHPLLSEEKQTSFVTIKTEDILSERPLKPPLSSRSRLKLKKVKVEIKHEDDNEDTGRRSQLDSLGQGVLLNGAATSVGLTAWEATSSKSLELSVVPVETKVEVICSGTRNHVDNSGKDLPLSQSAKINCSCSCHLSTEDICKLEGNDNSRESIEMETYTEEYDSGRDLLVVVKDKTTPTGFLPSTNAEDLSLSTSSTGQLAKNSLVGTLETRIVGRRYNRGIFCEEGMQVTLLRDPENPKDPNAIKVVPLETPLGPAVGHLPKEISAHLAPLLDKAFVHVQGFVVTVPEQIHGDVPLKLSFESASASTDLSLLDGAAESWQSMLVAAENVSSGISPTLRVSKYQHNFLAVMRTVLERDSHLFEDQEKHFLGTFYALSGDAQRLFIRLYQRKGPWFRLSSLSYKDVADVTTASDELLASGFMSADCSAQEEPGASMRTRIEILNMLELRQLSALLKKKKEAASARREELVSLIVSTAMEKQWNIEVSSSSRSRTVMESVAEITGPCIRVSEQAEFLLWRLQRLFFLDKGRDLSSFLVVDMGLVKYPQYKCLKSRHVFPSHEALVAYEQALEVAQGMDMSLELNDTEKALEFLRRARNEMSVCQVVESAVDKTPSFLARFSASYVYRNVITVGVSILERERRYKEAVEVLKELLRSKVRSGRWGYWTLRLSVNLDHLGCKEESLKVAESGVNEPWIRGGDRVALQRRVVRLGKPPRRWKRPPYADSLNRKCKEVQIRGRPLNCVTGKKSRFYGYDGEQCGVEELALQYYASEEGGAWQGVHCEGGVWLTLFGLLMWDVLFAEVPDVFQNPFQTAPLDLNTDLFYPSRQDLIETRLAAIAVGNTESIVTQSWNKNFGTMCDGVNWERHSLAELLTIATCIGGSGLSHVCRLLAEDHAGWRGGMPDLLLWRTSANTSSDCSKCSMCGCSVTDVSLKIKPIDSMNCEDLCLGEEGCKNVTKDLVLSTRNTALRGEAKLVEVKGPRDRLSEQQMAWIWILMNGGLSVEVCKVLEELKD
The following text describes a protein:
Function:
Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).
Sequence:
MPVTLINNNKAVKLELPKSQASAEVLFFGATVTSWKVAGGSERLFLSSKAALDGSAAVRGGIPLVFPVFGSPKDHDDVPELITKLNKHGFARDHDWALSTHVASVDQEDKASVTLELRTNDKPDIKAVWPFETVLQYTVTLLPHQLKCELKVNYVDGEGDMPFHALLHNYFLVPDSTKASVQGLNGMFYIDKVLGGEEVQLNTDNFTLDAQPIDRVHVGKHKTIPAGEKPRDVKLVYNASLLQDPLGRMGKGVEVTRSKQLKDTVVWNCADEGNKLIKDLEDGDWKKYVCVEPGSVHGFETLPKGSKWIAEQTLTAW
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MSDDSEEFRSGSEDEEMSDYGASDADMDVEDDDDDYGFAGAEEVSTVPKVPYKVLPKEDLNKQREKALREVMDVLGIDEDTAMRVLRKYKWDSSRVQEEWFSKYDQVRESLGLVDEPGPSGRAACEAEERCFICFDSFPVRDMRSAACRHYFCKDCWRGYITQALSSGPACLDLRCPSTECKQKACVPCALVMELASGEEQSKYSTYMVRSFVEDNSSMCWCTGKNCENAIQCLVDRGPDEAMDVICSCSATFCFNCKEEAHRPVSCKTVKTWLTKNSAESENMNWILANTKPCPKCSRPIEKNQGCMHMTCSQCRFEFCWLCQGDWKEHGERTGGFYACNRFETAKKKGEYDDESRRRENAKASLERYMHYFERFDAHSKAREKARLDASKVSKDWLEQLADITKTPTSQLKFINEAWNQIVECRRMLKWTYAYGYYAFEDADRNSEVARHKGFFEFLQGDAERSLERLHEAAEKDLGAHVTKARNQADGGFDADAFQTFRKNLIGLTDVTAGFFDKLVKQLEKGFSSMEADYAGQVDDGAGPSGVNEGGEQAAGAAGGPAATGTTGHKGRRSKKARGVDEDVVLLGEQGFWTCNKCTYNNQDLTARRCEVCNEARAGPGGGAGNRR
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates elongation factor 1-alpha (TEF1/TEF2) at 'Lys-30'.
Miscellaneous:
MISCELLANEOUS: Present with 5170 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MITQTELDNCLQWAQNNGAFIDPKISFRITEDAGVSAFVNEKFSPKPDQALIRVPETLLITSQQALSEFSQAANERSLLNSVTQLYLSKLKFGTDAVHLKSFYKPYLDVLPLHLPQPYFWSTDEVMNLHGTDVYLTMRDTLNKLVKEWRMLFQALSIEHSSQDKQFLSLFQENKDSAVVPLEQFCAHINGCKLEDSEWNSFVAYLWSYCIFNSRAFPRVILGRAGTDRTNLNEGFLYPIVDLLNHKNDVPVRWEMNEQNELCFMSQTTTFSAQDELFNNYGNISNEKCLLNYGFWDSSNKFDFSRLTLKLPSTLVSGLPVDFNKSGNFVTDDGETTILQFSLKISEPLPPVLLALFAYLSKLKSEETPTVRSVLEGIDQLTSVVSQRLLFYKNFKIKTSSTQKLRPHVIKLIKLYYQDNKKILNATTEKLSVLQKKIYSNNKEFSLSFKTIFKNDKIFANSLLLVFGAINYEDLITKDCLNDALLLWIVKLINDKSNNQGGFIKQTFKEVSDSIVIEKEDVMEFLPFYKKYFPNLSERIPEIYSVGDWGIRQFIVADTAIDRLVWIRKSNKEPIFLMKKAYDLQI