lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Sequence:
MVNSKPNINIVFIGHVNSGKSTTAGHLLYKLGGIQKSAIEALGKEAAEMKMRSFKYAWVLDKLKAERERGITIDISMWISLIKNMIIGTSEADCAVLVINSTTLGLQAGWSKDGQTWEHALLAYTLGVRQMICCCNKMNATTPKYSKDRYEVIVKGVSPALTRIGYNADDIPFVPISAIDQISEPKRPEGKPLRLPLQHVYKIGGIGTVPVGRVETGVLKPGMVLTFAPTKLQSGVKSIQKFQENINEALPADIVGFRLTNKTLSDKNLMRGYVASNSEDEPAMEAAKFTSRVIIINHPSVITKGYTPILDCHTSHVAVKFAKLATKFDRETGVELEKKPKSLKNGDAGIVKMIPMKPMVVEGINEYPSLGRFAVRDMRQTVAVGVIMSVKKNGYKNKAATKMTGSTTDQKDDAETSSKKRKEGPFETVSAETPSKNVSGLVIGDDGLLHRKNVMSSVT
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
METFEESSDLDVIQKHLFEDLMIPDGFIEDFVFDDTAFVSGLWSLEPFNPVPKLEPSSPVLDPDSYVQEILQMEAESSSSSSTTTSPEVETVSNRKKTKRFEETRHYRGVRRRPWGKFAAEIRDPAKKGSRIWLGTFESDIDAARAYDYAAFKLRGRKAVLNFPLDAGKYDAPVNSCRKRRRTDVPQPQGTTTSTSSSSSN
The following text describes a protein:
Function:
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
METNRPSPDALLVNLQEETDSSVGKLKIYFGFAAGVGKTYAMLSDAKDQLAAGVDVVAGYIEPHARVETLRMLEGIPIISPKAINHKNIALKEFDLDEALKRKPELILVDELAHTNAAGVRNKKRFQDVEELLQAGIDVYTTVNVQHIESLNDIVEGITKVAVRETIPDYVFDEADRVKLIDIEPDELLKRLEQGKIYQPERAQTAMQNFFTRENLKLLREIAMRKAADRISHEYDQTGVYPEKRASSKWLVCIGTSPSSAKLIRWTARTAEAFRAPWTALYIENEENDYMTKAEKKCLRETMELAERLGAEIVTLAGHDIAETVAEYARLTGVTNIVVGKSRRRMGLRSLFEEDFEDRLITHLDNVDMHIIPSSHPKAKKRRMKMRFKSFLTWHDMAKMVLLLALATAICVGLSEFGIGDQNVIMVYILSVLIISRVTSGYVYGVLGSIIGVMLFNFFFTSPLYTFNTIQAGYPVTFGIMLLVALITSALTVRIKTQASLAVERERRTEVLYEINKQLLVTRNLKGIINLTNEYILHLFSRSVIFYSADPAKSNEGIFVQAEGKEDASALLSADEEAVAHWVFKNKKRAGAGTDTLMGAFGYYMPVMSQGKVLGVIGVSCSPEEGPLTQDNRIFLRMISSQVALALERQYLSEEQRQIVIESAKEKMRSNLLRAISHDLRTPLTGIIGASSALLEKEDELDKETERNLIRGIKDDSGWLIRMVENLLSVTRISEGLVSLERAPEAVEEIVGEAVGRIKKRFRDRTIHVKVPRDLLMVPMDGTLIEQVLINLMENALRHGGTGAEVWVDVTKTKQSAIFSVRDNGKGIPENRLADLFDTFAVEARERSDMSRGLGLGLSICMSIIRAHDGTLEAKNNKHGGATFWFTLPLDGGDGK
The following text describes a protein:
Function:
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MGELCRRDSALTALDEETLWEMMESHRHRVVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRFTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLKLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQQLQRANMVSSCELEFQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGAPPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGSLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYGASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTRKSSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEGSSMCFWAESCLTLVPYTLVRPHRPARPRPVLFVPRAVGKILSEKLCLLRGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYTSLAPDSWSDLDGLLSCVRQAIADEQKKVVWTEQSPQ
The following text describes a protein:
Function:
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (By similarity). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus speckle. Cytoplasm.
Sequence:
MATTAASSASEPEVEPQAGPEAEGEEDEAKPAGVQRKVLSGAVAAEAAEAKGPGWDLQREGASGSDGDEEDAMASSAESSAGEDEWEYDEEEEKNQLEIERLEEQLSINGYDYNCHVELIRLLRLEGELSRVRAARQKMSELFPLTEELWLEWLHDEISMAMDGLDREHVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLAIWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYEMEATFAEYEEWSEEPMPESVLQSYQKALGQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQTISATFENALSAGFIQATDYVEIWQVYLDYLRRRVDFRQDSSKELEELRSMFTRALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGTLEDWDLAIQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKKTRGADKRREDEDEENEWGEEEEEQPSKRRRTENSLASGEASAMKEETELSGKCLTIDVGPPSKQKEKAASLKRDMPKVAHDSSKDSVTVFVSNLPYSIEEPEVKLRPLFEVCGEVVQIRPIFSNRGDFRGYCYVEFGEEKSAQQALELDRKIVEGRPMFVSPCVDKSKNPDFKVFRYSTTLEKHKLFISGLPFSCTKEELEDICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIRENVIKVAISNPPQRKVPEKPEVRTAPGAPMLPRQMYGARGKGRTQLSLLPRALQRQGAAPQAENGPAPGPAVAPSVATEAPKMSNADFAKLLLRK
The following text describes a protein:
Function:
Required for conidiophore development.
Subcellular Localization:
Cytoplasm.
Sequence:
MAFFFNRGRSRQPSDVVRSIKDLLLRLREPSTASKVEDELAKQLSQMKLMVQGTQELEASTDQVHALVQAMLHEDLLYELAVALHNLPFEARKDTQTIFSHILRFKPPHGNSPDPPVISYIVHNRPEIIIELCRGYEHSQSAMPCGTILREALKFDVIAAIILYDQSKEGEPAIRLTEVQPNVPQRGTGVFWRFFHWIDRGTFELSADAFTTFREILTRHKSLVTGYLATNFDYFFAQFNTFLVQSESYVTKRQSIKLLGEILLDRANYSVMMRYVESGENLKLCMKLLRDDRKMVQYEGFHVFKVFVANPDKSVAVQRILINNRDRLLRFLPKFLEDRTDDDQFTDEKSFLVRQIELLPKEPIEPSRSAREPSRSTANTTTVA
The following text describes a protein:
Function:
Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
Sequence:
MNPAEHDEAVSQFCAMTRARPDEAQEYLATNGWDLEAAVTEFFAEQDETAGSSEPTGQPSAKSSSSTPRESSSSRKQPPKKFATLGDLASGAADSSDDDDDENQDFFAGGEKSGLAVQNPDDLKKKIIEKARRTQLPASDDSEPRRNYFTGPARTLGGEDTPSRVIDTPSGPAQPQIPRRVRRTLHFWADGFSVDDGELYRSDDPQNAEILNSIRQGRAPLSIMNAQHGQDVDVEIKQHDEKYVRPKPKYQPFAGKGQRLGSPTPGIRAPAPSEPAPAPQSSSGPPKPNVDESQPVVTLQIRLGDGTRLTSRFNTTHTIGDVYDFVSAASPQSQARPWVLLTTFPSKELTDKAAVLGDLPEFKRGGVVVQKWQ
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSYYFKNLQPGVDESSSEDELEQMLHGKQRADDASSEDDELSSLTFGSLKKAEDALQREEAHEAVHNRARAEARPRGSARSRQEASDSEDSSDSEAGFFEEDDRRRASGARRHKHAPSEQSAKRPVSKVRQIPGLESARREEPQPDIRFDKSLGRAEDLAKVRSNYRFLDDYRQQEISELSALLADKKFLRKASEREVQQLQQRLTSMRSRLQTVQNRDTERQVLRDYERSINQGNKTKFHLKKSEQKKVVQKWKFDHMKARQRDKVMERKRKKLRGKEFRSFEFHRK
The following text describes a protein:
Function:
Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. Involved in the tolerance to heat and osmotic stress by partially activating the ethylene-response signal transduction pathway.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Note=PubMed:16283071 shows a localization restricted to the nucleus and not altered by heat or ABA treatment, while PubMed:18201973 describes a transport from the cytoplasm to the nucleus induced by heat stress.
Sequence:
MPSRYPGAVTQDWEPVVLHKSKQKSQDLRDPKAVNAALRNGVAVQTVKKFDAGSNKKGKSTAVPVINTKKLEEETEPAAMDRVKAEVRLMIQKARLEKKMSQADLAKQINERTQVVQEYENGKAVPNQAVLAKMEKVLGVKLRGKIGK
The following text describes a protein:
Function:
Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTERQAVKELQVYKKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGDLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILKNIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTIVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENSKDYFSPELLVLYFASSLVIPAIGMIIYFARKANMKGSYSLVEAQKSKV
The following text describes a protein:
Function:
This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Sequence:
MASWKYPQLDVDELKIAKAVIRDVPESIRDLYNVCKAIRGMYLNDAKDFLNRVLEEKEALPFWRYNKGASHKSNISAKWKIKAGRYPKKAIRQVLKVLENAEANATNKGLDVDKLIIRHIAAHKGITLQRYMPRAFGRATAKYRRTSNIEVILEEVE
The following text describes a protein:
Function:
Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Present at both poles of the cell throughout the cell cycle whether they are growing or not. Located at the ends of microtubules growing towards the cell poles. An intact microtubular skeleton is required to maintain the location at the cell tips; on the other hand, a normally organized actin cytoskeleton is not required.
Sequence:
MSFLFKRNKGSAHKPTKPNFSKTSTTPSTSQLKHSHESNVKMSTSTVTEHRKKPTGSGSHITASPWSKLTVRGSSNVLPRYSHASHLYAEGGQEIYIFGGVASDSQPKNDLWVLNLATSQFTSLRSLGETPSPRLGHASILIGNAFIVFGGLTNHDVADRQDNSLYLLNTSSLVWQKANASGARPSGRYGHTISCLGSKICLFGGRLLDYYFNDLVCFDLNNLNTSDSRWELASVVNDPPPARAGHVAFTFSDKLYIFGGTDGANFFNDLWCYHPKQSAWSKVETFGVAPNPRAGHAASVVEGILYVFGGRASDGTFLNDLYAFRLSSKHWYKLSDLPFTPSPRSSHTLSCSGLTLVLIGGKQGKGASDSNVYMLDTSRFRLGSVPTTSGRQRNTSFFSNSTGNTNPSAFNGLLTSSRIPSYNGSKVRSTSHPSRQQYIGSSNSRFNTRHQTISTPVSGRASNDLPSPVVPTRSNSSSILQPSYNLNSHSSDRRNTNDDDQSSLNSQQLSNQAKAQGEVSPTLSFVPSSHSMEQGNGSVASANNAQSEAATRSINSISEVSEVRFPEQSSVKTVDERKSLDGRITSVTLETLVEKYSELSKQQIVEWFKSKLYEILRDSASKIDSLTEKLKVANAEKNAALCEAALEKVPLAKHNKLSDGTFSTPDKENVQSTNDAHIMQENFSLHKALEVMRETSSDLDKQLKDATASQKELIVQTSSFQKELVEERERHNAISKRLQEIESLYRDRELLVTNLEDQLVDQTVTINKFAFERDQFRERSMGFENTIKDLTRKMEATDMLNVSLHESLRSVQTENSELVTEMALLKAELVKKQAIIDANANIYDKLTADHTNYETVSADINQNLKETLDKLLNGSSDFKNNEIELLHDQIRITNAKLEKREKLINASKYIEDTLRSEIQEAAEKVSNLEFSNFNLKEENSNMQLQLMKALEQRNTGAKQLVNLRMQLSTATSELDMLKLKLRTTALALEESPDDYSDILSILRADMSPFHDLHKQCGVLIDTLNGVKRGFGIFEKKFTDYHKFLENISDKLKSEEDTSLETPIHENQSIQSDQIKEVGEVLSAIKSLSDSVMLLKNQIDDLAKEKLPLSSSDDEKVNIKEKTDFMKLLVKSGLSNPPAKEPVHDNEN
The following text describes a protein:
Function:
RNA-binding protein that may be involved in pre-mRNA alternative splicing, mRNA translation activation and stability.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MNGTLDHPDQPDLDAIKMFVGQVPRSWCEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKILPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPIVVKFADTQKDKEQKRIAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLLQQTAAASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTPSGTAALTSSSSPLSVLTSSAGSSPSSSGSSSVNPMASLGALQTLAGATAGLNVSSLAGMAALNGGLGSGGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQSLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Sequence:
MDTRGCAWLLLLLSLPQGQSHQPLHRSKRRWVLTTLELQEEDPGPFPKLVGELFNNMSNNVSLIYLIRGPGVDEFPEIGLFSIEDHQSGKIYVHRPVDREVTPSFMVHFDAVDRSTGKVVDESLIFNIRIRDVNDHAPQFPEKEFNISVKESQAAGQPIFQLLTVDLDQENTPNSQVLYFLVSQTPLLRESGFRIDLISGEVRLSGCLHYETAPLFTLIVRASDCGEPSLTSTATIHVSVEDSNNHMPTFMEDRYEIRISEGQVEQGVLYLPVQDGDSPFTPAWRTQFNIWDGNEEGHFDIVTDPETNQGLLSIIKPLDYESQVAHSLVVVVENQEQLFVCTEGQLQPLRKAMASTMVSVQVLDTNDPPAFHPQSFIVSEEDGAWPAIQLGYFNATDPDRADSQIRYKLVHDPENWVTVDEKSGVVTTKKQIDRESPHVNDSFYTIIVHAVDNGLPPLTGTGTLMLFLSDVNDNAPTLRPHSRHLEVCESAGSQPLLIEAEDADLDPYADPFTFDLDNAQGDVEETWMLRTKQGEGHSAELTMLRSVPPGDYLVPLFIADRQGLAQKQTVHVRICSCRSGSECEEPSDTWLLWWALSPVGAALMVLSAALLCLLRCSCTFGPKRLRGFIPSDSGHQTLIVYNEESKVPSAQGCDTFFEPRGVKTLLSSTPVYLDRMVPRQQPLQLLEGRVVEAWSQKLQSIDVLEGDTGYLPHVYREEGECEGAETLSSLTFLEQDLSPKLLGCSGSKSTPSEAMCFTSRVPS
The following text describes a protein:
Function:
Receptor tyrosine kinase which plays a role in promoting longevity and resistance to stresses including UV irradiation and high temperatures, probably downstream of daf-16.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKGTLIFVVFYSSYGFAHCNTILRSSSLSRNFEDSLRRIPRSTDKDETGFEDSNVQEVIFILLYCLFVALAILICGLIIFYNSRKRELRANRSRGDEYLLEPTSADHKRRNSSNIVPPEPTPYPITSGESDLRQTPSRLSNVECPPELELAPINEKIMYLHYYAEVEINEEDLDISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQQELIYDELKVMCAVGKHPNILALVGGITFGERKMIVSEFVENGDLLSFLRDNRIYFTNDQWTLETEQDSLSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKYVLSYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFFEKELKTTSNEYFLDLTRKLRSETNNQLRLSNWLSDEKHCDS
The following text describes a protein:
Function:
Transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MESTEAPSVAVVKSQVVEDAIGSTADVSQPPSHEVDSLRVAGCSDGVVVVSEIPCLTPSDDDFDHGEDRDQDHGDNDDVVVVEYYFSDENLPTDKFLLNAMKKNKKGFVPISTIATFHKMKKLTRDHALIVSALKESSFLVVSSDEKKVKRLSPLPEIRDPKIFTVLVENLPEDHTDENIRAIFGKAGSIKSVSICDPNAVEESEKGCKKDKFIRTRLHAFVEYESVEAAEKAAATLNNEQDWRNGLRVKLLEQTGKFAQRRPGRKEVDTVKDNTGQVHDQIGGEENKKSNEHQHHRHHHSDTPADNDSGDKNGNKTKSRGRGRRQNNQGGNGHGSSPSTSSSLHHNYHHHHVEVSKPPPGPRMPDGTRGFTLGRGKPLPAPTSAQTSHEA
The following text describes a protein:
Function:
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP.
Sequence:
MGQGLWRVARNQQLQQEGYSEQGYLSREQGRRMAASSIPNTSHRKQVQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNLPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA
The following text describes a protein:
Function:
Specifically catalyzes the degradation of N,N'-diacetylchitobiose. Key enzyme in the chitin catabolic cascade.
Sequence:
MKLNKLAIATLVSAALSQYAFAQTDTKGTIYLTFDDGPINASIDVINVLNQEEVKATFYFNAWHLDGIGDENEDRALEALKLALDSGHIVANHSYDHMVHNCVEEFGPNSAAECNATGDHQINSYQDPAYDASMFAENLSVLEKYLPNITSYPNYKANEFARLPYTNGWRVTKDFKADGLCATSDDLKPWEPGYSCDTANPSNSVKAAIAVQNILANNGYQTHGWDVDWAPENWGIAMPANSLTEAEPFLGYVDSALNTCAPTTINPINSKAQEFPCGTPLHADKVIVLTHEFLFEDGKRGMGATQNLPKLAKFIQLAKQAGYVFDTMDNYTPNWQVGNNYSAGDYVLHLGTVYQAVTSHTAQQDWAPSPTSSLWTNADPATNWTQNVSYKQGDVVTYQGLRYLVNVPHVSQADWTPNSQNTLFTAL
The following text describes a protein:
Function:
Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds. Substrate preference is thiosulfate > 3-mercaptopyruvate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSQSISSSTKAEEVVSVDVSQAKTLLQSGHQYLDVRTQDEFRRGHCEAAKIVNIPYMLNTPQGRVKNQEFLEQVSSLLNPADDILVGCQSGARSLKATTELVAAGYKKVRNVGGGYLAWVDHSFPINTEEEEPSAN
The following text describes a protein:
Function:
Mitochondrial inner membrane carrier protein that mediates the import of NAD(+) into mitochondria. Can transport NAD(+) by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP. Also able to transport NAD(+) by exchange with AMP, GMP or deamido-NAD (+) in vitro.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTQTDNPVPNCGLLPEQQYCSADHEEPLLLHEEQLIFPDHSSQLSSADIIEPIKMNSSTESIIGTTLRKKWVPLSSTQITALSGAFAGFLSGVAVCPLDVAKTRLQAQGLQTRFENPYYRGIMGTLSTIVRDEGPRGLYKGLVPIVLGYFPTWMIYFSVYEFSKKFFHGIFPQFDFVAQSCAAITAGAASTTLTNPIWVVKTRLMLQSNLGEHPTHYKGTFDAFRKLFYQEGFKALYAGLVPSLLGLFHVAIHFPIYEDLKVRFHCYSRENNTNSINLQRLIMASSVSKMIASAVTYPHEILRTRMQLKSDIPDSIQRRLFPLIKATYAQEGLKGFYSGFTTNLVRTIPASAITLVSFEYFRNRLENISTMVI
The following text describes a protein:
Function:
Cholesterol-binding protein which is involved in dietary cholesterol uptake from the environment. Does not play a role in double-stranded RNA transport in contrast to other SID1 family members.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRTSQAIFILIFLDSVRNQSPQVIPAKWDVVYEKETGHNMSLTVFRFQVKEQYSVARIIMSCNESTEHNPLLAVFREKLAILSLQVPLIVDNYEYSQVARTLCPFTEYKEGEAFTVEVTSSRPVHYNFRAELVQNFYLYNNSQRLVTASASEPVYLRYDIPGDVDSVAVHLDSNSTICMTVSVQKIGCPVFDLPDNVNSMGLHQTMTTSATIPVEKSRMSSFYVVFVVNTNDDLCSEILSIKPNKPTKFPLRMKSFNVTIESSMKIFDYTIPIVFWACILLLVTIVVFVYHYFDGIWERRFVSRAYTHLEDNAQEQRIRDFYDFQRMSEDDDLKDYDLLTDCQDMMVVRAKASLTVADLSMTPYEERELKYDVYKIALAIIGIFYNITVLQLIISKAGSLRQSGDLDECTFNFQCARPLWYFVAFNNVVSNGGYVYFGTLIIVMNYCRERSFRRLFAVQPTLAERYGLPQHSGLMTAIGLAVIMEGISSATYHVCPNNINYQFDTALMYVIGMLGKLKIWSLRHPDMVVSAYHAFGFLGVFLMAAIAGVYVHNMIFWALFSIIYIASMLLVSLEFYFKGIWTLNLRELRNSIRLSWVSSRHLSCVVPAYKARFFVILLLNIANTAVVVYGLEAHPKDFLSFLLIPFIGNLFIYIIYYILMKMIYREKIPKRAIALLFAAVISWTCAGILFNQRVSDWSKMPAISRELNKPCIFLNFYDNHDLWHLSSAFAIFFSFTAINVIDDDLMFVMRNTIRVF
The following text describes a protein:
Function:
Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDPESIMAADGTDSAPANGGLAMENVCVKENGAVSVETVDTTSESQNENSANSSTLDTIEHVKEAAEGTQVEHVDDSKCMKGEKAQRKPRHEKLSGGKNNSSVHIKKSKEGKSADAKVAASNGSVAPNVQTTNPLKSKSFNGREAQVTKQGKHDSAPAESADGEKVKPKSQKKQAHETSEDDTQSSNSPKADDGKPRKVGALPNYGFSFKCDQRAEKRKEFYVKLEEKTHAKEEEINSMQAKSKETQEAELRMLRKSLNFKATPMPSFYQEPQPPKTELKKIPPTRPKSPKLGRKKTASGADSEETQTPRLGRLSLDERASKDNPTAKGIMPTVDLKKQPVRKSLPRLPSQKTVLPDGKPAPAKAAIIPAKVRPEKKKLEKDAETVNQTSHPTEEEAQVTVSSNADVEDSHETVSPRMNEDRADKSIEVSEAVAVEH
The following text describes a protein:
Function:
Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. E1B-55K probably acts as the substrate-specific adapter of the SCF-like E3 ubiquitin ligase complex. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest. E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain. E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
Subcellular Localization:
Host nucleus. Host cytoplasm. Note=Colocalizes with host TP53 to host PML nuclear bodies. PML localization of E1B-55K is necessary for E1B-55K-dependent SUMOylation of TP53.
Domain:
Contains a PML interaction motif that allows the subnuclear PML localization.
Sequence:
MEREIPPELGLHAGLHVNAAVEGMAEEEGLHLLAGAAFDHAAAADVARGEGGGAEPCGGGEVNMEQQVQEGHVLDSGEGPSCADDRDKQEKKESLKEAAVLSRLTVNLMSRPRLETVYWQELQDEFQRGDMHLQYKYSFEQLKTHWLEPWEDMECAIKAFAKLALRPDCSYRITKTVTITSCAYIIGNGAIVEVDTSDRVAFRCRMQGMGPGVVGLDGITFINVRFAGDKFKGIMFEANTCLVLHGVYFLNFSNICVESWNKVSARGCTFYGCWKGLVGRPKSKLSVKKCLFEKCVLALIVEGDAHIRHNAASENACFVLLKGMAILKHNMVCGVSDQTMRRFVTCADGNCHTLKTVHIVSHSRHCWPVCDHNMFMRCTIHLGLRRGMFRPSQCNFSHSNIMLEPEVFSRVCLNGVFDLSVELCKVIRYNDDTRHRCRQCECGSSHLELRPIVLNVTEELRSDHLTLSCLRTDYESSDEDDN
The following text describes a protein:
Function:
Component of the viral DNA-dependent RNA polymerase which is composed of four equimolar subunits of LEF-4, LEF-8, LEF-9, and p47. Plays an essential role in late and very late gene expression.
Subcellular Localization:
Host nucleus.
Sequence:
MFVTRLEHTTQFLPQACKLEDEVLVLYAIYLNGFDYTLPRFVKREVQVNADGFVRFDYNIKMFDFARFTDMTQTTPEDIDDYINLTRINSLSDHDLKMLQLVCRDRWYKGDVARLRRILQQKDVDDLVKFVCNVMWERAYEDHYTLGQQLSIRITTKLIQSGLDFKHQPDTTAPVSVRGWEDATFEKYLQSITSISEVIKRHVFSKKYICLEVAASYWSDAVESLQQENFRIILNSKTPYVLLIEMDDDKNSMVYLRKLAHLLENKIVNLLFVTDVEFYFKNGNFMFYLYNSLKFYYYCLKNKFAFENVDKEIFFLLYTIVALEWFNGGHLNSFTLEKSALYNPLELSTRRLNSIKRAAQHNRVINCDSEINMDYIRGKRVRTGAHYGKRVVNFDLNQSLH
The following text describes a protein:
Function:
Transfers the sialyl residue from CMP-N-acetyl-beta-neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids. It's alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen. Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKRILLFFILAAAVMYGILHGNLWRNNFYWLPPTAVERRNALNTCILKPAFESLLDVEKIYPFLCASDFIRVAEYHGSDKFELPYGIKRAEQFFRSALSKLQNCGLSNKDDSVACRRCVVVGNGGVLRNKTLGGKIDSYDVIIRMNNGPVIGYEEDVGRRTTFRLSYPESIFSDPIHYDPNTTVVIIVFKPRDLKWLWEILGGQKISAKGFWKKPALNMIYKSNQIRILDPSITRKTAYDWLHFPTRFPKKEKPKHPTTGLIAITLAFHICHEVHLAGFKYDFTDRNSSLHYYGNETMSQMMQNEYHDISAEQKFLKKLIDKNFVVNLT