lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MFSPHVHLRMLAHCPPRRTRCGPLHGELKSPRSSLYFHRSENQRLACPHNVDVDVEVYLVVELTHRYPRQGCCLPAVTTTTPLFPFSLCVSLLRSRHCTALEPERLRTQSPTGKHAMTKAASLKKGSGDKRAREASLQEATARKVKVETAAMLPKASHDSQAHPNLFSWLLNTSRGEFFRKYFERKHLVASHGSGEYFASGLPGVVPPVNWSTERMLEHVKTHPSRYGADLDIVKFDPKLKRRVSYRTKGLVDAAELEACMKDGWSVRFLRPNEFIESNSAFIGCIEKEFNCYCGANSYWTPANSQGFAPHYDDVDVFFLQLEGEKLWCLYDPPEDVDVLARHSSEDYAPERFPTPKHTITLKAGDVLYMPRGTVHQGKTTLKTHSLHITFSANQMNSWADFMSRAAQYTVETLAANKLEWRRALPRDMPQVMGEVNNPVFRDTHGLPALSANQQDHRANLQTKVREMVAELTLLLTDEVNMDVCADVYGKDTIQKLQPPSRTYSGAAPASRKLSHASRVRLISRNCMRLLLNVPGEARVYHIGQNSTVCLAGELGELRFEADFAPAIATLLSSYPKTMPVSALPFPGFDNSDDVAENQLLLVETLRDAGLLHVGSSAKGNAPS
The following text describes a protein:
Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLRNEAVQDELAADFRTLTKTLYDLNKALGSSVVRGSPLKELVIENFDEEQIWQQLELQNNAVLDVFKKSVAQCTNDKDLCLISDQEDDSSDAEAISDSEVGDTIEAETEQDNAYTKHKTEAKEKKSKPRETVIEEYSDEDSDVDFDIEALEQETKTAKKTAVKNTGRKSVVDDKFFKLAEMEAFLEHMEKENGEREEEEEEDDIDYFEDIISEDEEEEFEEAKVKPVKSSRDLTYKDFFDPVDDNDDLVANDAEDYEDEEADSAIEKENEESMSEAEDINEVVTENMRNKKVSFSLPDDSETEDVMDMQLERGIDLNETKSSFEKRQEKMSEKIKSLEEELLEEKPWQLRGEVTGHKRPENSLLEETVLFDHAVRMAPVITEETTFQLEDIIKQRILDEAWDDVVPKERPKEDAFEYKKRITLDHEKSKLSLAEIYEQEYLKLHQQKTEEEENPEHKEIQEMMDSLFLKLDALCNFHFTPKPPVPEVKIVSNLPAISMEEVAPVAVSDAALLAPEEIKEKNKAGDVKTDAEKTATDKKRERRKKKLRKRIKLKEKEKRQKLLEKMKPEQGTKLSKKAAAAKLKKLTKEGKASLLKDEGKDKAVKSSQAFFSQLQDQVRMQIKDANKLKKKQKKQKDVSVHKLKL
The following text describes a protein:
Function:
Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters.
Subcellular Localization:
Nucleus.
Domain:
The JAZ-interaction domain (JID) (82-141) is sufficient for interaction with MYB proteins and most of the TIFY/JAZ proteins.
Sequence:
MNGTTSSINFLTSDDDASAAAMEAFIGTNHHSSLFPPPPQQPPQPQFNEDTLQQRLQALIESAGENWTYAIFWQISHDFDSSTGDNTVILGWGDGYYKGEEDKEKKKNNTNTAEQEHRKRVIRELNSLISGGIGVSDESNDEEVTDTEWFFLVSMTQSFVNGVGLPGESFLNSRVIWLSGSGALTGSGCERAGQGQIYGLKTMVCIATQNGVVELGSSEVISQSSDLMHKVNNLFNFNNGGGNNGVEASSWGFNLNPDQGENDPALWISEPTNTGIESPARVNNGNNSNSNSKSDSHQISKLEKNDISSVENQNRQSSCLVEKDLTFQGGLLKSNETLSFCGNESSKKRTSVSKGSNNDEGMLSFSTVVRSAANDSDHSDLEASVVKEAIVVEPPEKKPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYSLRAVVPNVSKMDKASLLGDAISYINELKSKLQQAESDKEEIQKKLDGMSKEGNNGKGCGSRAKERKSSNQDSTASSIEMEIDVKIIGWDVMIRVQCGKKDHPGARFMEALKELDLEVNHASLSVVNDLMIQQATVKMGSQFFNHDQLKVALMTKVGENY
The following text describes a protein:
Function:
Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Subcellular Localization:
Nucleus.
Domain:
The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. AHA motif is a transcriptional activator element.
Sequence:
MDYNLPIPLEGLKETPPTAFLTKTYNIVEDSSTNNIVSWSRDNNSFIVWEPETFALICLPRCFKHNNFSSFVRQLNTYGFKKIDTERWEFANEHFLKGERHLLKNIKRRKTSSQTQTQSLEGEIHELRRDRMALEVELVRLRRKQESVKTYLHLMEEKLKVTEVKQEMMMNFLLKKIKKPSFLQSLRKRNLQGIKNREQKQEVISSHGVEDNGKFVKAEPEEYGDDIDDQCGGVFDYGDELHIASMEHQGQGEDEIEMDSEGIWKGFVLSEEEMCDLVEHFI
The following text describes a protein:
Function:
Positive trans-acting factor capable of stimulating the transcription of the MET genes from the methionine biosynthetic pathway. MET4, MET28 and CBF1 are required for full induction of MET25 and MET16 gene transcription. MET4 controls as well the derepression of MET6. Required for the transcription of genes necessary for sulfur amino acid biosynthesis. Involved in the transcription activation of MET28 and MET30. Required for MET3 gene expression via assembly of the MET4-MET28-MET31 and MET4-MET28-MET32 complexes. Involved in response to cadmium and arsenic. Cadmium-activated MET4 also induces glutathione biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 1300 molecules/cell in log phase SD medium; MISCELLANEOUS: Transcriptional activation function is inhibited by the elevation of intracellular S-adenosylmethionine (AdoMet), but is activated by cadmium and arsenic which leads to phosphorylation and prevents ubiquitination. Inactivation by oxidative stress induced by hydrogen peroxide promotes ubiquitination.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MKQEQSHEGDSYSTEFINLFGKDTATHPSSNNGANNNGMGSTNSLDQFVATASSSSSLVTSSENRRPLIGDVTNRGNTNLYDHAVTPEILLEQLAYVDNFIPSLDNEFSNVDWNVNTTHNNANNNGADTFSSINANPFDLDEQLAIELSAFADDSFIFPDEDKPSNNNNNSNNGNDDHSNHDVLHEDPSTNNRQRNPHFLTQRRNTFLTSQYDQSKSRFSSKNKRNGNNGETNNFGDNMQNNHPFEPNFMGSPSQFPADATNMTSIDHGGFTNVDITSTENNTTGDNGVDALSNLLHRTTHTPNRSSPLSNVTSAQNSSSQQRKHSESKVDSNSDNNSSNKAPNITVPDYSIIPTSVLVTLLPRVNVPNGAYNSLISAGFDNDQIDAIAAIMAYHHQKKIRENNSNNNKNINTNDSQEAPILKNINELLSVLIPPSPAETRGPTTLSTSPSFNEHGVVAEASFLSSILELGIKHPKSNNIHNQRQPSRNDHKISRESDGNNGNDNVHHNNAVIKSSTTRGDEIAKIRSEPTLNASSSDHKENSLKRSHSGDLKNKKVPVDRKYSDNEDDEYDDADLHGFEKKQLIKKELGDDDEDLLIQSKKSHQKKKLKEKELESSIHELTEIAASLQKRIHTLETENKLLKNLVLSSGETEGIKKAESLKKQIFEKVQKE
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region.
Sequence:
MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAPHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVIQCYDPDTDLWSLVNCGQLPPWSFAPKTVTLNGLMYFVRDDSAEVDVYNPTKDEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPAGGRGFELNSGSNDVDAGYHRLPQNPEELH
The following text describes a protein:
Function:
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Sequence:
MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDDNQGIVEIPDVLIEDMMDAFEGCPTDSIKVADESFDGDALKFE
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Sequence:
MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSRSLADVTASAEYDKEAADLSDEKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWMGPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNPDVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRNVHLTEHGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLINASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAAGEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTRDVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGGSDEADHDRVAELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANLDHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVERRNTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIRESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARPTSTWTYMVNDNPLSDDTLSALSLPGVFR
The following text describes a protein:
Function:
Essential for the formation and/or stabilization of microtubules. Binds to microtubules in vitro.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic microtubules and mitotic spindles.
Sequence:
MDSKDTQKLLKEHRIPCIDVGWLVRPSASTSKSSRPGKSESKANSVAPDIQMDTARPPVFETSVDSSSSILSSNDKGRRHSVAASLLMDNQRANAGSTSVPTNIPPPRGRSKSVVETNLSNVEADSGHHHHHRHHHHTEDAPAPKKVGFFKSLFGHRKKDQEQQEKERERKERSPSPTHVDRGAAIRRERTATISAESPPPLQYNAPPSYNDTVVPLTRSKTESEVYYENHPQSYYHGRMRTYHSPEEGKVDGTSPADDHNYGGSRPDPRLMDFLRYYKSKDYKLAAFKEGNFIKSSASPTTKKNRRASFSLHNDKPQPAKSLAHQKFDAKGRPIPPHPDAPKLPSAFRKKHPSNASIVDTVDSNSDVSSSAQNNNQTPSSHKFGAFLRKVTSYGNNNNNSTNASSLSANVNNPDTSSTSLWSSSSMEFDPSKITTVPGLENIRPLKHVSFATNTYFNDPPQQICSKNPRKGEVEVKPNGSVVIHRLTPQERKKIMESTSLGVVVGGTGQLKLLNPEEDDANAKSKEEMAPQKQNEVEAHDEEDNNSQRRNIVMAAAEAAAEARAKEAPNELKRIVTNNEEEVTVSKTASHLTIDKPMISRRGASTSSLASMVSSDTNGTNADDEGEILPPPSLKIPHDIVYTRCCHLREILPIPATLKQLKKGSTDPIPILQLRNPRPSMVEIWSFSDFLSIAPVLCLSLDGVQLTVQMLRIILSSLVYKQHFQKLSLRNTPLDEEGWKVLCYFVSKAKSLHSIDLTMVPSIKTNVQKPSKSSLKSKILRMQCNLENRSDMNWDLLTASIALMGGLEEIVISGAKMNSAQFKNFILVACIATERLGLAYNGLSKSQCDDLAKWMVQSKVTGLDVGFNDLNGKLSSFTDAVLGKIQKANEKNVFKFLSLNGTNLRVNEHDTFENNEVLKLISVLCYLENLKFLDISNNPAIFPHCVPTLIDFLPVFVNLVRLHIDYNNLSSTSVVMLAEILPMCSRLNYFSMLGTELDLASSKALAEAVRKSSSLMTLDVDYVYMPENIKEKISLYALRNIQGELKRVNSDDKDIKDSQFSSLQDQLSLLLTEKADNSEHYNKMVENFMAKIALARIKISKVVHDLFDLKLNGQLNLEGKEALIRLCFIEASLERGCDLLKQRHNNTLKSPEAVSKSRKGGNQAQPNSESCQRMLLSSSILQNSDHIALMPFGSAIVEKSSPDAEDAVEFREGDDSNVNHEDVPANDQQFRDEVDIKNKYSIIKRELEHEKLVGGGDLPVDKEILNRAAQSLDSDQIKEFLLKNDVSTILGVIDELHSQGYHLHHIFKKQGNQEETAFRTKDEQQSSQSNDSSANASPTTDPISTGSNTSRTNDNAHIPPTDAPGFDKFMNNAEENAIDAAYDDVLDKIQDARNSSTK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MQSFSEGECLQAKKIQLRKRLLHFLQTQAYKNEFVWTEDSKIALLKELYSALLCYDESFWTPYFLDKKPIITGTFSLRKAQGSVDGDEYKRGRAKPVCGHVFRKGEVIFRCKNCSLDSNSALCVRCFRASAHKKHETSFSISTGSGGCCDCGNAEAWKQDYQCEIHAQAQEPLDSCSHPELIPTVLQLGIAETFACAINFIIDVISCSPEKLKRLSSVNEVLQNEVSSRFLESQYGMPDEPCTTFSLVLWNDEKHSFKQFYEQITTAIEAPNNKFGMQMADVINTTGRAVVATSHNINDLLVMAQCLSQINLAVSIRSTRDLFREEACGVIIHWLDDLADSHTFGDRNYLRLILCSTLRRPWTCGLQNVTQTLQHAIITNPLSSLDETDTDTTPSRLSQSSQSSSASYSRSCWAPCVNEVAAPSFAESTKMDYLFLYDLKLWKSLRYKLQEMYLGHLVWQPNFREFMGIRIAVLYRQLAESFLLLDREPEHSVIFFSVQIFTIPQIAKQLVAKYDFLTTVNSALYTFFTDKNEQKPNFVDENAMIRTDSAAFHSRRYFHVFHHIQFLLGIESVQEIMRVDFRYLKQYISFLYLFQGMCPYVRAITQHVEWENDSWMYVLNVSLQIAKLCRYIGNVYVGLDTGSLAAAIQLLFDVILRPKFHNGSWNHKENLSVYTSTASGEKTLVDYDVASQCVSFHHPLHWLLSTLLSNYVGRKDTQKLWSDEQLLAVIEHPIRVCTWLSQMRAKLWVRNGTTLRDQAHHYRDLSFHGYTFAMDVLLIQVAMVYGNTDSVFERLVKAFQLTDQMTGNYFNEHKHYDLTQLTSMFEDFLLLIISLVSNVVGLENWSASNCIKYDLIHILCFGPLSYSEIVKRVSEHLLERTEFEEVLHTVADFKPPEGLNDTGLFTIKSECLDFVDPYNIHFSRNQREEAECILRRKYGKQQFLDENNVVYELYSHSYATPLTTRIVMCNSYLQTIWHALVYAYLFPTDQCKFEGLVNISLHAILLALSHETSEPFDFSRSVCVKKFSVPNGLRLYCSKPEVSLLTILAQLKSHKLFAFSRPRIIGILQLLQKRLSAEFEMCFSDSVAASIPEVSLDISCKENQEKEEKLKRARERKARILEQFRQQQKQFLENNADFNDYDSNMDINDNDENESLDENADLFLTPPSDTCLLCQEELKDKNSYGILVYVQRNSLLRYLPGDNVSYLSELLELPSSLDRKVSSRPFGVAGMKKKKMDTLPIEELDDDCLKGFPSDCLRKGLQVTSCGHYMHTNCFKTYVSTVNMTTRANPYRNHPHNLSMKEFLCPLCKSLCNSIFLLMSKPHKEKRLSECTGPDAIRDWITNRVYLERDSLQTDDLFSSDCCLSLFSIDVLQQRLRNTLKEQYVSSFTLPQENRIASRTDTLRVELSSCGSESSVSSFLETHKNYEYVYVTEGVYELYRRLEDVLDLNLTVYTDGFIIANGKLVNVLELYSYTLACTEVSQRGTNGVDKSQTMLWFEVLTPSQLVFLRVLSVTVMTYAALSMNDFRNGLSGTSSEYATLVAGQHYRLFGASVPGFFSTQVPNQGAKYDTLLSKDIFTEFAEASVSGFLIHEESFITLTKCYYLADTVKTIWFLLKQLDTLKKCPVPRNYPVRTPQALLGFKHLVYYIWRYVCTSERMNQSPEDCPELNNASFLSMLLDLTEKFALVFLRKCALLWYVRYGIHFDTFPAEDLDKSEMDRITKALDLPTVTGNCNTLLQKESLTEWKLIEHWCQSHIANSPYREYSRVYTPSIYELVPLPREQDLLFELLLGRTCSKCQTEPLEPAICLFCGQVLCFQSHCCSFNGVGECSLHLQQCASNIGIYFIVKRCCILFLNPPTGSFAAAPFTDLYGEADLGLRRGRSQFLRQDRYDAFVRNVWIQGGVSSYIARRLDLQVDIGGWETL
The following text describes a protein:
Function:
Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MVDKNSLRKLMLLKRAELNDLEKSHLDQKINQKLMAFLITRPTIKNLALYIPIKNEVAFLDNFLDFLKLNKITSCFPSIVDQFNMKFIDQNNNEINPNDIDCFFIPLLAFNKANHRIGFGKGYYDRYLSLTSKKQLKIGIAYDFQYAEFTNDPWDYQLDLIICNG
The following text describes a protein:
Function:
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3. According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. However, the small molecule kinase activity was not confirmed by another publication. Shows an unusual selectivity for binding ADP over ATP.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MLGDAIMVIKGLAKLTQAVLETQLQYLGFGGEIITAARALQTTAEEQFSLVMARMQGADQAQERYSDTGDDPGSEFHFSGPEATQASDFSASAPPPPPPPFPDQFHREGLAPAYVSSGPFGEAGTSGQPFGPASGKIQGKLFGDFRDPFAASSMQRRFFHQDQSSVGGLTAEDIEKARQSKTQPGNKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPQLAKIFDRVRQSADFMPLKQMTKTLNNDLGPNWRDKLEYFEEGPFAAASIGQVHLARMKNGREVAMKIQYPGVAQSINSDVNNLMAVLSMSNVLPEGLFPEHLIDVLRRELALECDYKREAACAKKFKELLKDHPFFYVPEVIDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDESFTDVYIQIIRAAANRDRETVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFASDSPFDFGSQSTTEKIHGLIPIMLKHRLVPPPEETYSLHRKMGGSFLICSKLKACFPCKAMFEETYSDYCRRKAEKQ
The following text describes a protein:
Function:
Pre-mRNA binding protein, binds avidly to poly(G) and poly(U) RNA homopolymers. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
Subcellular Localization:
Nucleus matrix.
Sequence:
MAAGVEAAAEVAATEPKMEEESGAPCVPSGNGAPVPKGEERPTQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNLGPAGMGMEGIGFGINKIGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGSGAGGSVPGIERMGPGIDRISGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMDRMVPTGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGAGGASFDRTIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity).
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.
Sequence:
MAASENNMEEINPVLRISQLDAIELNKALEQLIWSQFSSCFQGFKPGLLTRFEPEIKASLCLFLWRYTIYTKNATVGQTILNMQYKNDLAVTKKYRPLNKQQKVWFALFLVGGKWLEERSFDLFSNHPFGASFQRTKYFLNAISGLLKFGALLNFLIFLQQGKFATLTERLLGIRSVFSRPQDVRQVGFEYMNREILWHGFAEFLIFLLPLINTQKLKSKLFSWCKPAKSHGVSDPSLAVICKECCLCGEWPAMPHTIGCSHVFCYYCIKSNYMSDMYFTCPKCSSQVHNLQPLEFKIEISEVHTL
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MSQAVKDYYEILGVNRDATKEEIKKAYRKLVRIYHPDINPDPSAQEKFKEINEAYHVLIDDERRSEYDAILSRNDVGKFRDFLEYIQEFVESIIQGEKGKKRRPRKGQDIKMKLPLTLEEAGLGCEKEIIYSRWMDCPVCEGMGVKGEAETVVCHACNGEGRRVSGIFNFPRPCSVCKGKGFIVKNPCPTCYGRGRVSAQHKIKVHIPPGTEEGEVLKVPEKGHLGYFGGKPGDLYLKVVLKEHPIFKKVGKDLHMEKVVSFPLAVLGGTVKVPTLEGEEIDVFIQPGTECGATKVVKEKGYPYENGRGDLIIHIRIGVPKNLSKSERKLLEKLAESIKEEGEEVYREGGSLVEKLSSLFKKNA
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Miscellaneous:
MISCELLANEOUS: Present with 5550 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MACNFQFPEIAYPGKLICPQYGTENKDGEDIIFNYVPGPGTKLIQYEHNGRTLEAITATLVGTVRCEEEKKTDQEEEREGTDQSTEEEKSVDASPNDVTRRTVKNILVSVLPGTEKGRKTNKYANNDFANNLPKEGDIVLTRVTRLSLQRANVEILAVEDKPSPIDSGIGSNGSGIVAAGGGSGAATFSVSQASSDLGETFRGIIRSQDVRSTDRDRVKVIECFKPGDIVRAQVLSLGDGTNYYLTTARNDLGVVFARAANGAGGLMYATDWQMMTSPVTGATEKRKCAKPF
The following text describes a protein:
Function:
May regulate a gene cluster involved in mycofactocin expression. Mycofactocin is a conserved polypeptide that might serve as an electron carrier.
Sequence:
MPHESRVGRRRSTTPHHISDVAIELFAAHGFTDVSVDDIARAAGIARRTLFRYYASKNAIPWGDFSTHLAQLQGLLDNIDSRIQLRDALRAALLAFNTFDESETIRHRKRMRVILQTPELQAYSMTMYAGWREVIAKFVARRSGGKTTDFMPQTVAWTMLGVALSAYEHWLRDESVSLTEALGAAFDVVGAGLDRLNQ
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MLLSQMEIETAQSPKTKMESLRSICDREVRVHQQNLDSFTALFPTSLHFIKALAQDAAQAHVKLAKLKTNLREAEDELVKVLAAKTRKEAKQMATRDSISAIKARVEEFKRTVQVQKARRDEYESIISQESLALAKFEKVRHEIKENGEIHEAISWYNRVLGFQIEGGHGVKFTFNDMNIENPKQEYCLTIRHANDAYSLLDCDPPLNGIGELINELNRTNGLFKFVRIMREKFQEAAALGLQPQSTSFRQGSSAISMSCPALSVSTDISESSTKKNKHRVPLQEVNRQVEEVNYRSKSTSKATENKLYDGRFNRYSKKPN
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MHVGIVAQRGNERATSLAGEIREQLRALEVTVWVDTATAEALACAGECGRDTTAFTDCDLVVSIGGDGTFLFAARGAGATPILGVNLGEVGFLNAVAPADAVEAVREEVNRYRETGAVRCREVPRVVAAGDGWASTPALNEVAIQGEQRGHGHGVAVDVRVDGSQYEATRADGVLVATPTGSTAYNLSEGGPLVQPSVDALVVTEMCGADALPPLVTGLDSEIRIRVETLDDGGEGRVVVASDGGRLTRVDPPVEMTVTAADEPARVAGPAADFFEALSKLE
The following text describes a protein:
Function:
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May play a role in BRD4-mediated gene transcription (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDDEDGRCLLDVICDPQALNDFLHGSEKLDSDDLLDAPVEAQSAFYEGPGLHVQEAAANHLNPEPSQPAPSVDLDFLEDDILGSPAAGGGGGGGGAPDQPCDILQQSLQEANITEQTLEAEAELDLGPFQLPTLQPADNGAGATGAAGATAVTAGPQALFPGSADLLGLQAPPTVLTHQALVPPQDVVNKALSVQPFLQPVGLGNVTLQPISGLQGLPNGSPGNAAAATLGLTPIQVVGQPVMALNPPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLPAAVTTTLNGNSVFAGTGAATAAASGAPSGQPLAVAPGLGTSPLVQAPSVILHRTPTPIQPKPTGVLPSKLYQLTPKPFPPTGATLTIQGEPGTLPQQPKAPQNLTFMATGKAGQNVVLSGFPAPALQANVFKQPPVTTTGTAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGTPAVQLPQSLSALPANVGGQILTAAAPHAGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSAAHILSAAPIQVGQPALFQMPVSLATGSLPTQSQPAPTGPTATTVLQGVTLPPSAVAMLNTPDGLVQPSTPAATTGEATPVLAVQPATQVPPAVTTPLPMGLQQPQAQQPPQVPTPQAATQPQATPPQASPSLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQERSQQPLSTEGPHLSVPASVIVSAPPPAQDPALATPVTKGAGLGAQTPDSRASPAPAPQIPAAAPLKAPGPASSPSLPHQAPLGDSPHMPSPHPARPPSRPPSRPHSRPPSQPQSLTCPPSEPTLHPCPPPQGPPTLPGIFVIQNQLGAPPPASTPASTAPGPPQPPLRPPSQPPEGPLPPASHLPPASTPSAVASSSEPSARLPVPTPPDFQLQFPPSQGPHKSPTPPPALHMVPEPTAPPPPPPRTFQMVTAPFPALPQPKALLERFHQVPSGIILQNKAGGTPTTPQTSTTLGTLTGPTASVLVSGQAPPGTPAASSHVPASTPMATTGLPPLLPAENKAFASNLPTLSVAKATVSGPGKPPAIQYDSKLCSLKKQPLLQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPNDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTLALDKQLAKEKPDEYVSSSRSLGFPVPVSSEGHRLPSHGQSSSSSTSGTSAQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSTSSSSSSSSAASSLDADEDGPMPTRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPLPAPTPAKGAEPPPHPAPPPLPPATQAQMNGTLDHPPPAVRKPTVPASCPRLPLRKTYRENMGNPGAAEGAQGRPRGAGSPTPLPTKVDEATSGLIRELAAVEDELYQRVLKGGPPPPETPASATSQGPTEPSWEAPVLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAGPYPHTGPTPGTPTSPAPLHRPDAFPPSSHNGGLGARTLNR
The following text describes a protein:
Function:
May be involved in protection from oxidative damage.
Subcellular Localization:
Mitochondrion.
Sequence:
MSRNTDSPRSSQPSSPPSLQPPAARSSSYFTYPISYAVSGVLRRLNTEGAPKQEANGNPRTETSSNSIQSQLFDTASSLSHSFASLVSASSTSASDMNDVFRPPHRYASPFQPPPLTPLTLKGYRPGTREKGRLLSKALAEEIRLLVPPRLQLVDEWKLAYSLEQNGVSLGTLYKISEDYRGRRGGYVLVVKDGSGGVFGAYLSDPPHPSSSFYGNGECFLWRAHILSSLPDLAMNLPPPPSADTTHATRMTTISSPTRASRKDALSLPDSGSTSRSGTSTPERIRFKAFPYSGVNDYMIFCEHSYLSIGGGDGHYGLWLDDNLENGVSDTCPTFGNEPLSDDGKKFEVMGVELWYIGS
The following text describes a protein:
Function:
An aminopeptidase; acts on free N-terminal amino groups with a very strong preference for Leu in the first position.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEFAVALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQTPEFSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDYDRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIPVVSVTKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVPEGPGINDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDALKGIALYLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAGKTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQKTDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP