lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.
Subcellular Localization:
Nucleus. Note=Localizes around gamma-tubulin during M phase.
Sequence:
MNWNEKPKSATLPPLYPKSQPPFLHQSLINQITTTSQSSFSYPGSNQEACMYPGNSNPISQPLLNIQNYPQQISVSDMHNGTVVASHTSVERITYANVNGPKQLTHNLQMSSGVTQNVWLNSPMRNPVHSHIGATVSHQTDFGANVPNMPALQSQLITSDTYSMQMQMIPSNSTRLPVAYQGNQGLNQSFSEQQVDWTQQCISKGLTYPDYRPPPKLYRYSPQSFLPDSTIQKQNFIPHTSLQVKNSQLLNSVLTLPSRQTSAVPSQQYATQTDKRPPPPPYNCRYGSQPLQSTQHITKHLSMEVPQSREMLSSEIRTSFQQQWQNPNENVSTIGNFTNLKVNTNSKQPFNSPIRSSVDGVQTLAQTNEEKIMDSCNPTSNQVLDTSVAKEKLVRDIKTLVEIKQKFSELARKIKINKDLLMAAGCIKMTNTSYSEPAQNSKLSLKQTAKIQSGPQITPVMPENAERQTPTVVESAETNKTQCMLNSDIQEVNCRRFNQVDSVLPNPVYSEKRPMPDSSHDVKVLTSKTSAVEMTQAVLNTQLSSENVTKVEQNSPAVCETISVPKSMSTEEYKSKIQNENMLLLALLSQARKTQKTVLKDANQTIQDSKPDSCEMNPNTQMTGNQLNLKNMETPSTSNVSGRVLDNSFCSGQESSTKGMPAKSDSSCSMEVLATCLSLWKKQPSDTAKEKECDKLRTNTTAVGISKPANIHVKSPCSVVGNSNSQNKISNPSQQTALSMVMHNYESSGINITKGTELQIAVVSPLVLSEVKTLSVKGITPAVLPETVYPVIKEGSVCSLQNQLAENAKATAALKVDVSGPVASTATSTKIFPLTQKEKQNESTNGNSEVTPNVNQGKHNKLESAIHSPMNDQQISQESRNSTVVSSDTLQIDNICSLVEGDTSYNSQIAKIFSSLPLKMVEPQKPSLPNQQGIGSREPEKQLDNTTENKDFGFQKDKPVQCTDVSHKICDQSKSEPPLESSFNNLETNRVILEKSSLEHATEKSTANDTCSSAAIQEDIYPQEIDASSNYTPQDPARNEIHSDKAPVLYLHDQLSELLKEFPYGIEAVNTREGSVGQQTTYQTSEDQTADKTSSDSKDPADQIQITILSSEQMKEIFPEQDDQPYVVDKLAEPQKEEPITEVVSQCDLQAPAAGQSRDSVILDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSSSEEEKQKEQCSPLDTNSCKQGERTSDRDVTVVQFKSLVNNPKTPPDGKSHFPELQDDSRKDTPKTKHKSLPRTEQELVAGQFSSKCDKLNPLQNHKRKKLRFHEVTFHSSNKMTASYEQASQETRQKKHVTQNSRPLKTKTAFLPNKDVYKKHSSLGQSLSPEKIKLKLKSVSFKQKRKLDQGNVLDMEVKKKKHDKQEQKGSVGATFKLGDSLSNPNERAIVKEKMVSNTKSVDTKASSSKFSRILTPKEYLQRQKHKEALSNKASKKICVKNVPCDSEHMRPSKLAVQVESCGKSNEKHSSGVQTSKESLNGLTSHGKNLKIHHSQESKTYNILRNVKEKVGGKQPDKIWIDKTKLDKLTNISNEAQFSQMPPQVKDQKKLYLNRVGFKCTERESISLTKLESSPRKLHKDKRQENKHKTFLPVKGNTEKSNMLEFKLCPDILLKNTNSVEERKDVKPHPRKEQAPLQVSGIKSTKEDWLKFVATKKRTQKDSQERDNVNSRLSKRSFSADGFEMLQNPVKDSKEMFQTYKQMYLEKRSRSLGSSPVK
The following text describes a protein:
Function:
Probably part of an ABC transporter complex.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTIDDASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDMNVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMIGEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFMNEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAVKHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MEELIIYTTNKGACAVDLHSGNNITHFKNDETAPNLSVFLTNTPSGNPLLFSAQTKGAMMHVYNWNRESVDQQIVLPEKLSCLAASTCGTWLAGGSASGRLFVWELASGKLVFSREVHYQAVTKLAFTDGLLFSTSKDARVLGWSLVTMASDPKDCQPCITWTEHNLGVVDLVVGGGPTRDTRVFTVSTDKTVRIWDVSSTALLTTITLPAAETPTTLAVDQLERTLFVGCASGNILSVSLYDVSPSTGLVSVGGASGVVESGNVALSHHKSAVTSLALSFDATLLVSADDKGFICVWDLPSRQVSRSIKQPRAEMNPVTYVQTITTHGLPTEKYNPKTAVKLPMLKRVQDDKPEDHDILVKIQPRQKTVAHEDTLQQMVESAQFGGDSLAGKVVQLENELSQAKSSFASLKESHDTLWNIYQRQQ
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSAQIENSIPLDFDLGNMAAFDISPLDETKLSGSEKESFLFSLSRDNVQQLVNKMISLPKERTSDGVLLQLPETVTPLPRAKPLPKPKPETKWQRFARIKGIAPKKREGRLVFDEASGEWVPKWGYKGKNKELETQWLVEEGEKEKKLTSKQVRNTSKKIKRSRRH
The following text describes a protein:
Function:
Bifunctional enzyme involved in flavonoid metabolism.
Sequence:
MPEYCVTGGTGFIAAYLIKALLLKGHIVRTTVRDPDNAEKVGFLWELDGAKERLKIMKADLLVEGSFDDAIRGVDGVFHTASPVLVPYDDNIQKTLIDPCVNGTLNVLNSCKKSSTLKRLVLTSSCSSIRYREDAQQISPLNESHWSDLQYCQKYNLWYAYAKTKAEKEAWRVAEECGIDLVVVNPSFVVGPLLAPQPTSTLQIILGTVKGMIGEYANKRLGFVHIEDVVGAHILVMEEQKASGRYICSNSVRHMSQINDLLRTKYPSYPHENKCGNQQGEDIPHSMDTSKITQLGLPPLKSLNEMFDDCIQSFQEKGFL
The following text describes a protein:
Function:
Has a role in the mRNA export process. Interferes with mitotic chromosome segregation when overexpressed.
Subcellular Localization:
Nucleus.
Sequence:
MSMELDQSLDAIIASKPKGGIRKRRARSNKPKPTKNAKPAVNTASALKSVISEESKIIVSNLPTDVTEAQVKELFVKSIGPCKRVSLAYGPNGRSKGIATIIFSRPGDATRAYEQYEGRLVDGTRKMKVEIILDPSRQLNSLAARVSPASNASATASKNGAKSSKRKTTRRRRTPNRPKKSAEELDKEMDDYFGSNEKE
The following text describes a protein:
Function:
May play an important role in maintaining the flux of carbon towards starch formation.
Sequence:
MAALYSTSSCFCGSLGSYPVHKSVKLGHGKVRDSGFYFPHRFQCATPKLHVQAKALSVDGLPEIMDSSLVVCFGEMLIDFVPTISGLSLAEAPAFKKAPGGAPANVAVGIARLGGSSAFIGKVGEDEFGYMLADILKENNVNNEGMRFDPGARTALAFVTLRSDGEREFMFYRNPSADMLLQENELDFDLITKATIFHYGSISLITEPCKSAHIAAAKVAKDAGVVLSYDPNLRLPLWPSAESARKGILSIWDTADIIKVSEEEISFLTQGEDPYDDAVVRKLFHLNLKLLLVTEGADGCRYYTQEFSGKVKGLKVEAVDTTGAGDAFVAGTLSQLASDLSLIQDEDRLRNALKFSNVCGALTVTERGAIPALPTREAVVNALLKTVA
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MADWSLLGNFLEEVQEHSTSVGKVWLTILFIFRILVLGTAAESSWGDEQEDFNCDTLQPGCENVCYDEAFPIAHIRFWVLQIVFVSTPSLIYVGHAMHIVRREEKRRKGEKDEEKGERPPVGRIRLRGALLKTYVLSILIRSVMEVVFLCLQYIMYGIFLNPLYVCKAWPCPHTVNCYVSRPTEKNIFIVFMLAVSAVSLVLSVMELHHLAWKHCCRYLLCKRAASSANTSSPRHLSMSPLPPSSPPPDFNQCVTGSSPFLSLPFPSHLLVHQQNSENTVTEKNKIIQDGVYLKSDSKCYSPESRDNNCLQIQNCSPDGLLVKDKRRFSKASGTSSRTRADDLSV
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MNQYETVFILTPVLSDVQMKEAVEKFKGILQAEGAEIINEENWGLKKLAYPIQKKSTGFYQLVEFNADPTVIDKLELNFRRDERVIRFLTFKMDKYAAEYAAKRRSVKSNKKED
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MAQEFVNCKIQSGKVVVFIKPTCPYCRKTQEILSQLPFKQGLLEFVDITATNNTSAIQDYLQQLTGARTVPRVFIGKDCIGGCSDLISMQQTGELMTRLKQIGALQL
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MAKTPKSADKKMKTIFSYFNKTPSEKRSALTSQSDQNSEIDKVASAPKLRDEEIVANLKVNEGDLVWAKMQGHPWWPSLVCKHCKEGKFWKKENATMKIHVQFFGSPPSRGWVKEMSIKPFTGSSSKDCQKGGFLHCHQAAWKDALKEADKALHVSVEARDKLVVTIDSSDDLKKGKDDKENAPGNSESMSSSSTPKRKSTRNTGKNKRRRIIMDSDEEEEAGDDSNEESFQPSTEEDSTDDGVSEGDSDETNNNHNSDDDDDDNGGKPIKTKKRSRGGKIKSESKVEKSPTRGVVRVFPNQIVKRSRPKKLKKTDDDKDDDMKIDMCDDSEDRKTQVKTAQTTSPNSSGQRTFPHTSFKFLQPPYIMDANRRKEDDPDYDPKTLYVPVDFLNKQTPAMKQWWVLKSQYFDTLLFFKMGKFYELFHMDAVIAVNELGLLFMKISTNNEHFHVKIFESNHYSVINYTSTICTQGDHAHCGFPEISYGRYSDILVQRGYKVARVEQTETPDQMQERCKQTKSSSKIDKVVRREICSVQSKGTKRSSFIDGDCSGTNHNFLLAIAEKNVGSKSTYGVCFLDVMIGKFYVGEFEDDRHGSRLRTLASHHPPVQVLYEKGKLSEKTKMIFNGCLSQCLKEGLKSSTEFWDATKTLKQLHELKYFLPAGNDDNDDENADGVDNKTEWPEIFHKLTDPDDPLRLTPSSTFQLALSALGATVWYLRRCLMDEELLSLKSFELYTPVDYNTEQTNGRSGSEHGNISNVDEDAADESYSSQCNRSSQSVESTNKRMVLDGVTLVNLDVLVNSSNGTIEGTLLQKLDSCKTAFGKRLIKQWLCSPLCNVSSINDRLDAMEDLMKVKEVTASIVPLLAKLPDLERLLNKIHTLGSSKRNKNHPDSRAVFFEDVVYSKRKIEDFLQTVEGFRTTLSIIKKFSNSTSDFKSNILKQCVLMKSEDDQVGRGAGRFPNIKPTLDFFDSAFDHQKARSAGVIKPMLGVNKNYDCAVNDIKSIEDKLNGLLDHLKKQLGCKTLTYFGTARNRYQVEVPEAFCRKISDDFEVTSQRKGFKRYQSEEIKRWFAKLMDAEDRRDEAQRDTMRCIFDQFDRHYNKWIEATQCIAVLDVLLSLSVYSGQSDGVMCRPNVVPYLKESFVEIRSGRHPCIGGRTFVGGDYIPNDTIIGQQDESSSSPRVLLVTGANMGGKSTLMRQVGLICLLAQLGCYVPAEVCRLTPVDRIFTRLGASDHIMSGESTFFVELSETSCVLQHATKHSLVLLDELGRGTATYDGNAIASAVLQELSDNIRCLTLFSTHYHTIVERFSSNRNVSLAHMACMVENEDDDDPTQETITFLFKLSSGNCPKSYGFNAARLAGIPDQVIREAHTKARQFEESVRTIKMFRQLWRMKSSEAATKNISSIISQI
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MLVPLNSHHLSSYSDDSDVSASEDTMDLITEMAALGLPTSFQSRSAIQEKGSKRPSESSILKSESKEAVEAEPVAPVLFSVRSVQLFSAKEHGPEEITLDRLEGLVYDCQAMEDETVLAGPEHRILNHDQGDGLDGVELACEFEDKSDKQINPESRGDEVARYAAAVWEPVWDEQYQRYYFCNTQSWESTWDPPPGLEHFGVGSMAWSECNSADQSQVAHHSETSCVLPASILTFESSCEASGTVDMDKKLSSDVDQVEADDVHAHDTSAVVLQDEDVIEPVGCEKASALETSFRKLSQENETPERLPSSDVAMEDECGPVAEGEPPSSSDCLTSCASPAKSGVVNKLEEVIIQVSAAESSTMTEGENHSVESLPVFPQACGVHTRFIDSEDSGTEAEDDEETNWGEIEERQSAPNTCEDETEAWSLCFKNGTIESTESLVQLSGQRVKRRRVKSLSESEKLEKVLLPGMAETMSKSLIKYWLQRYSLFSKYDEGIKLDEEGWFSVTPEVIAEHQALRCPTGLVIDAFTGVGGNAIQFALKKNYVVAIDIDPTKVELARHNAEIYGVSDSIDFIVGDFFLLAPSLKADFVFLSPPWGGPEYLNQEIYNIETMLQPTDGFTLFKIAQTIAPNLAMFLPRNVDMDQLQELSWLSSPPLPCQVEKNYVDHRLKAITAYYGELVGQKQE
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated.
Sequence:
MPGSRPPGGPGSGSPADLLRRRAIGAHAVTAAPLAPPASGGLGTLGEEEESGSSTQASAPAMEAVPAGIFATPKPRGAVTLANWATYWDRKLEVQPTGRGGTFNVYLAGDSGPVVMCIHGGGYSGLTWSLVAKKLKDKYRVVAPDMRGHGLTKTDNDTDFSKETMSDDIIAIWEHMFGAAASAASSGAANSKEGPAPSGDSTPSTPAPTAPATAPPAAAHGPGTPAADAPPAGVLVGHSMGGGLAVWAGAAKRIKRLEGVVVVDVVEGTALAALPHMMNVLAGRPASFPSLEEAVTWAVRSGMSRNKEAAAVSMPGQLQQQGGAGAGAGGAGGGPGGGGGGSGGDGGGQWTWRTPLELSRPYWEGWYMGLSEAFLQLSCPKALVLAGTDRLDRALTIGQMQGKFQLILMPTAGHAIQEDEPDRTAEHLLGFLKRFRVGEPPMVFPRAPTGIKPVLPVVAGPVLEH
The following text describes a protein:
Function:
Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 9S-, 11- and 13R-hydroperoxy fatty acids. At the end of lipoxygenation, the intermediate products 11S-HPODE and 13R-HPODE from linoleic acid are then transformed into 9S-HPODE as the final product. The intermediate product 11R-HPOTrE from alpha-linolenic acid is transformed into 9S-HPOTrE and 13R-HPOTrE as the final products. 9S-HPOTrE is further oxidized by the enzyme to 9,16-DiHOTrE as the end product. Also acts on gamma-linolenic acid producing 9-HOTrE(n-6) as the main metabolite.
Subcellular Localization:
Secreted.
Sequence:
MRIGLLAFAVAARYVEALPVASGEEVASSSAPTTLPSTSSSSALPSPTKYTLPHEDPNPEARKAEIALKRGGFLYGPSTLGQTTFYPSGTLGTAMSQRDQALWLRDAENQTITAYREANETLRDIQSHGGLKTLDDFALLYDGHWKASVPEGIEKGMLSNYTSDLLFSMERLSNNPYSLKRLHPTKDKLPFSVEDKVVKQLTATTLAALHKAGRLFFVDHSDQKKYTPQAGRYAAACQGLFYVDARSNQFLPLAIKTNVGADLTYTPLDDKNDWLLAKIMFNNNDLFYSQMYHVLFHTVPEIVHMAAIRTLSESHPVLAVLNRIMYQAYAIRPVGERILFNPGGFWDQNLGLPATAAVDFLSSIYAHGEGGFRAGYVENNLRKRGLVGDTFGGPALPHFPFYEDAQRVLGAIRGFMQAFVDSTYGGDDGALARDFELQDWVAEANGPAQVRDFPTAPLRRREELVGILTHIAWNTGGAHHVLNQGAPVRASGVLPLHPAALYAPVPAAKGAVASSDGLLAWLPDEVKSVEQVSLLARFNRAQVRDRNQTVRNMFAAPELLAGNGEAYAAANARFVEETGRISREIEGRGFDSKGLSQGMPFIWTALNPAVNPFFLSI
The following text describes a protein:
Function:
May be involved in lipid homeostasis.
Subcellular Localization:
Cytoplasm. Mitochondrion. Golgi apparatus.
Sequence:
MCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGELVAQFLTSDMDSLSYLKKVSAEGHLYNGFNLIAADLSAEKGDVICYYGNRGEREPVVLAPGTYGLSNALLETPWRKLCFGKQLFLEAVERGRELPRDALVAQLLAVLSNDEAQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS
The following text describes a protein:
Function:
May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.
Sequence:
MQRALPGARQHLGAILASASVVVKALCAVVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGALAYLLTYMASFNLVYLFTIRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVVPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHGLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSAWPSMDDDEEEAGAKTDSPLPLEEASTPPGKVTVPESSLITLETAPLL
The following text describes a protein:
Function:
Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MYIRSTLPILGFSATGMAAYVLEDDYGTSTSFFDKFSFFTDPDPTGGFVSYVDRNTAQDTGLIFANGAVYMGVDHTNVAGSSGRQSVRLTSTKSYTHGLIILDLEHMPGGICGTWPAFWMLGPDWPSHGEIDIIEGVNTQPVNQMTLHSTDGCSIANGGFTGTLLTSNCYDYAPSQDTNAGCGIAATSSRTYGTGFNNAGGGIYATEWTSAGISIWFFPRGSTPTDIRAGTPNPTNWGPPLAKFAPGSCSFDAHFSEMQIVFDTTFCGGWAGSVWGSGSCASVAPSCQDFVANNPSAFREAYWLIESLKVYQDAPGESNNMRMNATSHLNVQLPRKGGRRSPGLHGRGFLEGTGKW
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MEQLYAAPVLPTACKKCSRGENPICRNLTEITTHVHFKPQMQFNDLIPLLSTYFFLGCYIYFSVRKINFVKSKIGMAFSAVVSVMASLMMAVGLCSLIGLTPTLNGGEMFPYLVCIIGLENILVITKSVVATPTHLDVDRRVALGLSREGCSITKNLLLEFVLIGIGYFSFIPEIQEFCAFALVGVLSDFLMNMMFFVTVLSIDTRRLDITEDIYTLTDDDLDNDEFNTYSERIKRKQIKKKRRDLVHSVETGGKNATYLKIPKRLKVVFFFADTRMVQRGLMVSMVIWFVLLVYSDPVGIRKKAQSNLKYDDSVANKFDFFDSTLEVRCNLFNLFHTCAKNVTSPSPAINTNGEINWSMKDLQSYEYLSFRHWPTLFAYYNITLAERFISILPPILIPVTISPDDAKLSRYPQQQSLTTTQDKHTDAHFYTGRYQMTGLDYYLTLLLDTLACLQYPGMFMVFILHIMYRCVCSRNYANWRKPRRNRQTVGSYISSVGDSMPIVLAGHSQLIECVRAEGTNVISSDISSELKVWDSHSGDCTCTIQRLVNRIVKIHHNIRNRPIFIHHVVLICLREYSLESQEISQSSIHKHQPMKGNCLIYFLTYYLSSFYNLCCYIMWFSIKETMVWCLTMCGAMIVTGCDDGSLEVWDSTSGELKCHHDAGKPGVVFMDSEGTRIVVARLSGTLDFFILDGSRMSRENQQLFLFTGTTNRHRNNSSELLMDHPNSNQLSLQLIYTVKSAHQQPISAFKMALGRVLTGSCDHTLKLFTTQDARFQSTMFGHIGPITVLYMDKATGAVSGSTDGCVRLWDLLTGLCLHKMEEHAGAITAVQCSTSHVLSTAQDNRLCIWSRRSGMLLQVTKLDIGCSSALCLLGESWCVTGGSGSLLLWDIRNGELLRRVELYYGSIVPPNVVQVFPISDLRIVCVLGHEMRIVRFPSVLEKID
The following text describes a protein:
Function:
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Sequence:
METGSPRKIQFTMPLLDSHLDPEAAEQIRRRRPTPATLVVSSDQSSPVWTAQLFGMVLYIDGITGNSRLQIKQPRPELQFLVEHHLYRQQQQQGGGGDECSSESCLSDRPSPDCGQGSAELPEDEAGWDAEDKISPEGFEKLRRQMEG
The following text describes a protein:
Function:
With S4 and S12 plays an important role in translational accuracy.
Sequence:
MVNNNIEIIEKLVKVNRCTKVTKGGRKFSFSVIVVVGDKKGKVGYGLGKADEVMDAKRKASDEARKNMFKIPLREGRTLHHDIVGKFCSGKVVMRAAPAGTGVIAGGPTRPLFEVLGIKDIVAKSVGSNNPHNVVKAAIIGLRNINTPKMIADKRGKKLAEIASQRETT
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWQAYVDDHLMCEIEGNHLTAAAIIGHDGTVWAQSANFPPVKPEEITAIINDFNEPGTLAPTGLHLGGTKYMVIQGEAGAVIRGKKGAGGVTVKKTGMAIIIGIYDEPMAPGQCNMIVERLGDYLLDQGF
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSAQRLFQRLSRPSRSSFSFTTAISRRSFGSSAVRLNDGDGKDRAPSTAPEHRKYQTSRPPNPAVPHSTSTMTNDFPSVGERTPPPEVLSSVDPNYKPVDPYPGRVEHYTGGRQQPGAQKPELGVGEMEGITFKVEPLRRTGEDPATMRARLLYQSRKRGILESDLLLSTFADVYLKDMTPEQLQEYDRFLDENDWDIYYWATQDPPSATDSPAEDTVTETWKRTGAKSGEWKQTVGAYKAAYRPVPSRWADSEVLRLLRQHVRDKSAVGFHAAKNKKTGGCGLGRMPDIQVFDK
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain (185-200) is required for interaction with COI1.
Sequence:
MDAVGAAGGGAMLPAAARRGQPPQPPCMTTAPEQQAAAGGAVIWPAAAAAEAKEKMVVDARTMQLFPTRSADGVVVSPAPAPAAAQERRRPEVHVTPSVPATAPTAPLTIVYGGQVLVFEHYTAEAAEKLVQRTQHLLAAAAGGGGGNKNNNVTVVTPPPDEPPMLLPPPQMPAASGVSAGGVMPIARKASLQRFLQKRKQK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
QRLAGSGFPEDLARRQGFGEYVREHPAELRRLATVILPGNPEVELLTPEGSDDSQLLSARQAIQAQCREALGWLLWCAFDRDLASGLEEVKAQCGARGVCGAVWGVNDIAYRCHTCEHDPTCAICVPCFQAGDHSTHDYSMIRTSGGCCDCGDGTAWKESGFCSRHRGPGKVPPLSEGMVARLGPVLEAMLLEWKDRLSAAVTASSGRPRKWSTMSPEEKLASPLSMSIISLLLEFCNCSESMLSFTAEKLSSSDIGLLDILLTAEFLLPKNVYTKLHELLYKLLGDPNFKYRFAQTFIKRYPKFLRESLQEEQMLARQPREHSILGSFSVQIFTVPTLTPRLVVEWKLLDMLFGILKDFFVSCIGDDGRFVVTRPAIQERAYMRAVEDVRYVMSHLKVAQYIIHEFPQLCRTWLHFLAFIQGMYPQKRITSIHIEEESEDWVAAFLLETQMANIHRLFVAGTCLTGNDTSWGSDTQAQGGIQVGIQGAVAAGSEEHSTEAFCIVEGAKLSKALIWLIAECVGVLDLWFAADQAREAGKAAKLASGAARGDAGLRRKIQPRVRLARGMTRDRHITNAVRHRDYTSRRSLEAVRAVPEAAEPASEASEMDIDGSSDTSETSEWWWMGASLEPEGTSSSLLTGDNEWPALEFDVGKQEVSFHIPLHRMLGLLLQKALEEYESQISASPPTSPSGTLLQLFPEAFRVTGLPALLMEHPLRIQVLCSQVHAGMWRRNGHSIVGLCDIYRAVPWSVECLELDLFMLQCCASMAPAEEFAGRVFTCFGLAEYFSLYLWKPNEYEPVLAQEMLVLLIRIISERGFCGLSPKESLRRELIQRLAIGDASHSSLTNALPPRLRDNEHMQETLEAVANYKRPHGMQQGKYVLREQSWRELDLYHPRWTPRELQSAEERYLRACKASAHFCQPPRWRKPFLPLQSLSKIAVSAKVHEILRALFFHAAFSPNLSESRAPESLLFTALHLLSLGLDVCNTFANKSSAEASSVSGPSISSVDHPPLLALAPEFVHVGGADGTQLFDRQSTLSLLVILMRKYIASEGAQLIISETSQSNVGCFIKKLLHNFAELDRQCMYAIESLAPEILHRVSTDSSSKAEGTSQDELQAELSDIEKKRAHARERQAAMMAKMRAAQEKFMASVESSKSSNKLDTSKTEGKRPRETLADDDMNETGTPLCALCRDRSSTSPLCMLTLVQKSRLLALSQKPVPSWDKPSRVVDDTPTAEDDNSASQTLVRREAENLILELRQWLEGAAADPNVDRLTNRDDFVELLRGGLPSILNTERFPATTSGIEVDTDASLDDTYGESSHPVDPKWWWELAEMVSNKESTDNNETLITVLAEYVAAVSRSQSELQPQPEDPPRGNRRRYGIESKVYRDVGLDFIGLHLSACGHAAHYECVERYYASLLQRYYSRSLFEGVQIVDPDLGEFLCPVCRRLSNSILPVLDPSARTPFVADAVEGFRLEQACSLMVSAQELVARPGFRNSVSRKLADPLRMVLESVSKRLSALYCLEKEKLYTSEGRNCQGLFLWDLLRYSIMSAELAARTRSLILGNHDAASRLVALEEASEASRGSTLPLLSLAANLTLTHSRQIVLLRSRGMQLMVGSVCHGTSLDFFSLLHFLEKGRDSADIQFWKRVADPVLAHDPFSSLMWLLYVLPLPIPAREGPLTALVHLFYLVCLVQCLASMGRYVVDDSVPAHLQNFLAVIHATLADTCIALQSPEGPVTAPLQFEQIRLFTLPYLRRCALLQTVISGTSQPVPVAGSNSWELSNVYNHLSSSAYREAAESCRDTEAVEMKEVEELERRFSIPPMQAILSEEAVQNLVVKWCQHLQSETGSRSFSIVPRPVRAVALQLMVLPRLFQDLIQRYVKECCPRCKTVPERPVLCLLCGRLCCGSGTNGCCSVQMQSECYRHAISCGGGVGVYLMLRKTNVLLLRRERQTMWPSPYLDAYGEEDQDMRRGKPLFLSDERYAALTAMVASHSLDYSSSVLAQTIREPLF
The following text describes a protein:
Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Sequence:
MNLETTEHLQRLGQEPERIRNFCVVAHVDHGKTTLSDYLVASNGILSPQLAGEVRLLDSRPDEQERRITMKASSVVLRHLHEGVEHLLNLVDSPGHIDFSCEVSTAMRLCDGAVVIVDVVDGVTQQSNGILRHAYREGLSMCLVLNKVDLLITVQQLSPEEAYYRMRSIVETCNAALAGFANQLKIQEEDCVAGKERDDPSDDVWFCPTKGNVLFASCHDGWAFSAEFFSRLYEGKLGVPDLQKHLWGEYYLKPQMKGVDTTPRRAGQQTLAVQLMLEPIWKLYSVFLDEKDDGPEKQLSMAAKLGIPEKLWNNPRRGQRGKLKALLSSWMPLAKCVLSTVCSKLDSPVSAQRRRLRFLIPRFDEAPTAVREALMNCSPAPDVPCVVYVCKLVDTQFLVGTTLGREGNDDDAFIGFARVYSGRLRPGMKMYVHSDDKVVEATVGKVFLFRGAGLDEADEVCSGTLCGVGGLTPYIAKYATLSSLEGVPPLNPLVLPSTSIVRASVFPRDPKDLFLLQQGLRLLYKVDPQVEVSILPTGEHVIGTAGEVHMERCLRDLIDTFARVEVMVSESIVSFRETIVATGPSAKPKLHTATTPDGAFAVTLYARCMPQEVLDIIKDDNKNRGTAGHVIQRIGGALNANKRWSKEIEHGVVACGPQKLKFVGVTLLLNFSEHTDSLGVLQRFNHWKDSIVAGFQAAAESGPMAQEPMFNIAFVITDINVEASTSLTGGMVLPCVRDACRAAMELHSRRLVEPVYECTVYSSGATQGKIYGSLSRRRSDIIEEVPNEGSDLFYIRCLLPAVEAFGLQDELRVVTQGASTAQLQMSHWNVLDADPYFTPTTREEIEEHGAEVATKNIAEQLLERVRRRKGLHRERVVENAEKQKFSLKGA
The following text describes a protein:
Function:
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
Miscellaneous:
MISCELLANEOUS: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
Subcellular Localization:
Cytoplasm.
Sequence:
MISENLGENQTEKIPLKGRTLKELSEIMITLGEKPFRAKQIYHGLYVNRYETWDQFTTFSKIFKEKLEELCSLTHLQVVKQLKSVDGTQKFTFTSESGNGKEFEAVWIPSGDGGRKTICISSQIGCTLNCKFCATAKLEFQGNLKAHEIVDQILQVEKIVGDKATNVVFMGMGEPLHNYFNVIRAASIFHDPDAFNLGAKRITISTSGVVNGIRRFIENKEPYNFAISLNHPDPKGRLQIMDIEEKFSLPELLQAAKDFTRELKRRITFEYVMIPGVNMGFENANKLVKIAKSLDCKINVIPLNTEFFGWRRPTREEIAEFIALLEPAGVPILNRRSPGKDIFGACGMLASKS
The following text describes a protein:
Function:
May play some role in mitochondrial processes.
Sequence:
MVVGAFPIAKLLYLGIRQISKPLANRIKAGARRSEFFRTYVCLPPAQVYHWVEMRSKMRIMGFRGAVIKPLNEDAAAELGAELLGEAIIFLIGGGCLVAEYSRQATNSRRKEEEMEARLGSMEAEIARMGLLTEELETRARVAERQQLAGK
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MYEEPLLGKSRDATRGKERQLQQEAQEEEIDLGVVIHQLNSFFAVLWPVSIAIISSSLAATYISDPAMKQAMTTYMYYQDIDSSAMSTAEKTEEALFNALLVIVFIAFLTFGIVLLYKCNGMHIFAGYCMLYSAALLGLMGSKLVVIVLCHNLHWVVDAVSLTVVMYNFAMVGVLSIFYQKGIPGIVERGYLIVSSVIVAWQLAQLPEWSVWMLLLLLGFWDLFAVLSPVGPLRCLVDLVQEKGTPIQGLLFEADVVDAHVSKNADVQQISNVKRRRFATRETIPEEAFMHRLLRAAQTENAVHDRAAVDASQFQHQVQAFLYDQNSKCQDRSDELAHSFEYNQLRLWRNLYSYYGIDYVSKQQPYPGVQAVFAASPDKNQDQTQQHSGDDDREDKSIKLGLGDFIFYSVLVARASLHGFAVFAACFLSILVGLGVTLYLLARFDALPALPISLFLGITVYLLTITIISPLVDELQASNIFTI
The following text describes a protein:
Function:
During phage morphogenesis, plays an essential role in the head-tail joining step. The associated nuclease activity is essential for morphogenesis, possibly by cleaving packaged DNA to enable the joining of heads to tails. Displays both exo- and endonuclease activity.
Sequence:
MAYSGKWVPKNISKYRGDPKKITYRSNWEKFFFEWLDKNPEIIAWGSETAVIPYFCNAEGKKRRYFMDIWMKDSSGQEFFIEIKPKKETQPPVKPAHLTTAAKKRFMNEIYTWSVNTDKWKAAQSLAEKRGIKFRILTEDGLRALGFKGA