lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Core component of multiple cullin-RING-based CBC (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. As part of the CBC(fem-1) complex directs ubiquitination of tra-1. As part of the CBC(lrr-1) complex, required for the ubiquitination and dissasembly of the CMG helicase complex from chromatin at the end of DNA replication. Positive cell-cycle regulator that is required at two distinct points in the cell cycle; the G1-to-S-phase transition and mitosis. Also required for proper cytoskeletal movement and mitotic chromosome condensation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nuclear in oocytes.
Sequence:
MASSTKVSLRRPPRPQVMYSLKPKVVEFDKVWVQLRPSIIDIINLRPITNVQWHHKFSDVYDICVSIPTPLSERLYNEVKACIQEHVRQKRQDIVDVDPDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQKRCTDLDNFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNFPHIANEVSGVINSFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSALAQKMLTDLSCSEYMEQVIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKLHAVCHDLITNEENKDLRNMYRLLKPIQAGLSVMVKEFEEYVKKKGLEAVSRLTGENVPQQFVENVLRVYNKFNDMKTAVFMDDGEFSSGLDKALQGVVNSKEPGQSVPKASERLARYTDGLLKKSTKGLSETDLEAKLDSAIVIFRYIEDKDIFQKFYSKMLANRLIASTSISMDAEELMINKLKQACGYEFTSKLSRMFTDIGLSQELSNNFDKHIADIKTVQPDVKFVPTQTMILQAGSWPLNAPQLSTNSNNQTAQDVANFHLPRILQPVIQEFEKFYTGKHNGRKLTWLFNMSQGDVRLTYLDKQYVAQMYVYQMAALLCFERRDAILVKDIGEEIGVSGDYLLKTIRTILDVTLLTCDDQNLTADSLVRLNMSMTSKRMKFRLQAPQVNKAVEKEQEAVANTVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQTKGRFSPDVPFIKKSIEDLIEKMYIQRTDQNDEYQYLA
The following text describes a protein:
Function:
Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKPVRGLHPKGGNMRKDSMTGYVLFFVSLLALIYTGERLWEDYIIKVQLSSTDPSIRHQAKDTVSLDETLRLIDCKEQQRKLVDAELELAAAKRQGYKPINCTSVNGHRKIVVGIFTNFGGQSRRTSSRKNWLPSGSALKELENDKGIIIRYVIGRSSNRGDMLDRQIDQESKETNDFLILEDHVESDDDVTQKTRLFFSKAVHIWDADFYVKMDDNIGLNLDMVASMLSKHHDKPRVYVGCMKAGVVVFDPNAQWYEPDWWKFGEQKSEYHRHAAGQVYVLSRSLALHISINSAHLKDYKNEDVAVGAWMLGLDTEHVDDRSLCCGYNSGIFLTQSYFINADAHTCEDFSLITMHL
The following text describes a protein:
Function:
Serine/threonine-protein kinase which, in association with cyclin D-like protein cyd-1, is required for the progression through the G1 phase of the cell cycle during postembryonic development by phosphorylating and inhibiting lin-35 and fzr-1. In complex with cyd-1, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP).
Sequence:
MTIRHILAIRKKSLELPSDLKTFLRVLANCQHLKKNKKCRRTIFSVDFQNNQRQKPSNFHFWTVIKKFSKKILKSFIIKFGNNGTIAVVFSIFPTGATPSLTFLFQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIPRGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSPEVLLQSYYNSTVDMWALGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFLKPAVATKSRVLKQINFNK
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Down-regulates activation of NF-kappa-B (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCGQVLKDLLGGGIDYEKILKLTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSSLQARLRACSLRVNRLVGVGWRVDYTLSSSLLRTVEEPLVHLRLEVAASPGAPAQPVAMSLSADKFQVLLADLKQAQTLMSNVG
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MAAGFVLTPHKLSMCVLLQLYAAPPALTPPFPLPAAVRHQLALFLLGLAKACDGFLEPTLEDLGMQLKECLGSIGEVIAEQLASRLLGFSSPEDLFTFVVLGLRGKLFRGGGNEDSLLVEHNSPLGQFLRRCILSFNILSFEGTCRLLAELDAYRRPALSIGDGNIVAKDSLSCQQAEGDDDEDEEEDRLEDDEDENVIASVTPVHGRERHGNGRRAFGVPLIPTEEMHRVRVALLPLTGFVKRVEQVHYLQYLNSIHHGDYPAAMSRLHQYFDYSVGRFQAGLLTLGSMHAHFGHVTQALQASFSALTIHLTFSMQNNDDTCLAHSLAALCHLLSEVGVAAEVTKAGAIGDFDRSIGPQLAAQQHLLLSLNRCLKRALELKLPNLVAFSRLALAKFDLQVIRISGLTLRISPYLLGDLVHSMSSSGSQRITSGAFGQAPGMPGNSQTGRLGPLSESLLKLAGSSYLLRSCSWELYGSDPMMRASTLVHAYCYSKSASADDLSVAYVKLAHHLAAHKGYRVALTALEQAMKKFPLHARSSLRSVQLQFIHSQAINRGNTRLAWVACSELAAMASPVLGVDMELKFEASYRHALTLLACKNYSEAATSAGELFALCYKYDMQLHVVKVLLLIAEIHKKSGSAVTGLPYVLGSITLSQSLNLDLLHAASRVSLAELWLDLGADHAQRALDLLQQSLPLVLGHGSLELRARTNLCIARCYVSSTDFAVATAPELVLDPLQLAAEEFMNLEDKDQASEAFYLLATTFNSIGRMEDRDKAAEKFQQCVVEEP
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVLWSAKSKLYLCFLAFLIASLIGRSTASLGDHLPDFKECVKICQAENCRDGDSIIPLHLRLLLWTCPAECDYTCQHVVTDRRLARDPPMLNPVVQFHGKWPFRRILGMQEPFSVLFSLLNLLAHWNGIGRIKETVPAWHSLRPYYLTFGYCGLACWTFSMLFHTRDFPLTEKLDYFGAGANVMYGLYLAIIRILRLDQGKPRYKPTLRRLTTTICVLLYTMHVCYLSFWSWDYTYNMIANVVVGAIQNILWTGFSIVRYQKQGKVWMAWPGMIVVWIMLAMSLELQDFPPWHGLIDAHSLWHLGTVIPTAWWYMYLIKDIQNDVSSRRLKV
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry. Regulates light-and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (By similarity). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (By similarity). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (By similarity).
Sequence:
MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGVGCIPLLTI
The following text describes a protein:
Function:
Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPLLPAALTSSMLYFQMVIMAGTVMLAYYFEYTDTFTVNVQGFFCHDSAYRKPYPGPEDSSAVPPVLLYSLAAGVPVLVIIVGETAVFCLQLATRDFENQEKTILTGDCCYINPLVRRTVRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVNNFKGRQPENEHIHTDNLAQMPMISIPRVESPLEKVTSVQNHITAFAEVT
The following text describes a protein:
Function:
Activator of KIF1B plus-end-directed microtubule motor activity. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAAMYLQNQGFEEYASARRLSEEESRQDPETEPYKSKYKARELLLQLAEALQGFQDESQAEENIELTLQLAELWFHLGVNFSETEEVPTGEQYFSRCAELMQGHKMDQRCVNTCLNCLNQLGILWVSRSEPEKALKILQEAEDIYKMYMHNVGQPPLLLHELLSPEQTGSPKSRQAEFEKTHTLTLYYLAQTYPKLGDNEKSAAYCHLTLSRQLQSGHFQPIDWATNCATLSQYYVTRDNFTQGRHCLASASSVLSQVPEPSDETEDGENESAREKLERRKADISRCWLKYCLVLLQESRQALMDDIGELDRAKQTDLAKGGAVAGSKGSHNDDKQEKSEDPEKAEGADGPGCHHGDEKSQLRFESLELTALEDQVTDKKVTDFDQARAVFLVGQKYVNAAKEFYVLDGHVTDFVEITQDWSQLFRALSFFEQDFERRCKMHKRRADMLQSLLSELNQQHYLLVCRQIMYEIAEIFSEMLDLKVAIAEAADERPKVHAVKKINSLAQQSISHYQMFLDSLRKADKEMPKTFSEDTLRPALVANFCVGRLYSKFLSSDPQVKLQNMSKSLDHYQFVVDYCTSHPDIAELVKSELEICTEMSQLLPIQMEKIRLTLS
The following text describes a protein:
Function:
This protein is a multifunctional enzyme, able to activate and polymerize the amino acid Ile as part of the biosynthesis of the lipopeptide antibiotic plipastatin. The activation sites for this amino acid consist of individual domains.
Sequence:
MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDISHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGWCLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSAPSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQYNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEMLEAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVSEQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADFSFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELDKRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVSFMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYTSGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGASLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEALSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYILDTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWLPDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYVGDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQNIILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPIDFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLALLLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERKGLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEGHIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADIILDILEKITSNQVILHKR
The following text describes a protein:
Function:
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSQGLTAYRNVLRAANLAFKNDHFVLGQAKANIRKGFEDGRKLDPKDEDVKVRLEHINGVAYVLRTQVVQGQKHNPDEEKYQLNLHKDSEMGDNESIKSPPPMPTKGKKGKKVKCCSE
The following text describes a protein:
Function:
Displays ATPase and GTPase activities.
Sequence:
MTSFSAPGSPVDTVLLTSPAGAGRTEAIRIFEDLGYLCLNHVWPELVPTFLKHYAPIAPRLVLCLASRPEADAQAGLIAARVALRSLARTTVHVHLDCPEGVLLSRYALTRRPHPWFDHGKGLLAAIRAERTALEPVRALADEVVDTGPLELAQLRVHLGALVGGRPTELPVTVMSFGFKRGVPADAQFVLDIRFLPNPYYESALKPLTGLDVGVAEYVFASEQSQATYRSLLEFLRFLLHQYRQDRRSQLLIAIGCTGGQHRSVAFVERLSGDLAAEGFACRPSHRDLAVNRLQELSR
The following text describes a protein:
Function:
Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA. Can be activated by both (-)-ABA and (+)-ABA.
Subcellular Localization:
Cytoplasm. Nucleus. Cell membrane. Note=Localizes at the plasma membrane in the presence of a CAR protein.
Domain:
Upon interaction with ABA, the 'latch' and 'gate' loops change in conformation leading to a tight dimerization and the creation a surface that enables the receptor to dock into and inhibit the PP2C active site.
Sequence:
MSSSPAVKGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHDDE
The following text describes a protein:
Function:
May play a role in cell adhesion.
Subcellular Localization:
Secreted, cell wall. Note=May be GPI-anchored.
Sequence:
MSLITIFAFFIKATLVLSLDILTPTTLTGDQTFNEDVSVVSSLTLNDGSQYLFNNLLQIAPSSASVTANALAAVSVFTFSLPPSSSLSNSGTLIISNSNTGPSTEQHIVITPNVMANTGTITLSLAHTNTDSSSTLIIDPVTFYNTGTINYESIGSETNDPSLTGNILSIGSSGRTLQNLGTINLNAANSYYLLGTITENSGSINVQKGFLYVNALDFIGNTINLSTTTALAFISPVSQVVRVRGVFFGNIIASVGSSGTFSYNTQTGILTVTTNGVYSYDIGCGYNPALMSGQQETLSFQGNLYDTFLVLVNQPIPSDLTCAAVSSSITPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSSVEPSSPAVPSSSAEPSSSVVPPITPIPSSSVVSASVFDTSSTLPSSPTVPTSSVSPSSPTVPTSSVSPSSPTVPTSSESPSTLSTPSSSAAPSSFCPTCVSSGTPPAPSSSAVVPTSSAGGGNGGDNGQPGADGQPGAAGQPGAAGQPGAAGQPGAAGQPGAAGQPGAAGQPGAAGQPGAAGQPGAAGQPGAAGQPGAGSGGGSEQPTPGAGAGSGSADGNQSGTSSGTGNGQAGSGQAGSGQVGSGQAGAGQAGSGQAGAGQAGSGQAGAGQAGLDNTASGQSEGGQASAMDGDQSGRGGQSNSGSLLQPNAQQGTGSGTGSDTGADQASGESPGQIGDAQPGSGTDQSSGRHSLAAEARTSQSHSLAADARTRSTTRQTSVIAPGTAPGTAVVTTFHGCGTVNHKGMINILLALALLVLL
The following text describes a protein:
Function:
Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide.
Sequence:
MNVPVGHLRNVQVLGIDAGGTMTDTFFVDQDGDFVVGKAQSTPQNEALGLIASSEDGLANWGMSLHEALAQLQTGVYSGTAMLNRVVQRKGLKCGLIVNRGMEDFHRMGRAVQSHLGYAYEDRIHLNTHRYDPPLVPRHLTRGVVERTDMIGTQVIPLREDTARDAARDLIAADAEGIVISLLHSYKNPENERRVRDIVLEEVEKSGKKIPVFASADYYPVRKETHRTNTTILEGYAAEPSRQTLSKISNAFKERGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYKNIACSDIGGTSFDVALITQGEMTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDPYTRAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYLNPDNFLGGAVKLDRQRSVDAIKAQIADPLGLSVEDAAAGVIELLDSDLRDYLRSMISGKGYSPASFVCFSYGGAGPVHTYGYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINMPTETPDTDKEKAAATLQAAWEELTKNVLEEFKLNGYSADQVTLQPGYRMQYRGQLNDLEIESPLAQAHTAADWDQLTDAFNATYGRVYAASARSPELGYSVTGAIMRGMVPIPKPKIPKEPEEGETPPESAKIGTRKFYRKKRWVDAQLYHMESLRPGNRVMGPAVIESDATTFVVPDGFETWLDGHRLFHLREV
The following text describes a protein:
Function:
Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum. SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs. Involved in vacuolar processing and morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAGKAGRKQASSNAKIIQGLYKQVSLFLGMAIVRLFISRKVTIGQWIKLVALNVPMFVALYIIVLSGKPKYDGNRVVKQGIDLNDNTNLISYFFDLIYLSLFGNIGIIAFRTFKFWWCLLLCPIYAGYKLYGLKNMFMPGAQQTQADNRSKNANEGQSKSKRQMKRERRGETDSKIKYKYR
The following text describes a protein:
Function:
Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
Subcellular Localization:
Periplasm.
Sequence:
MTRMTRHLALWMLLSLAILASQSAMAQKLPDFTSLVEEAAPAVVNISTSRTVETRNMPFGQFGGQELPEIFKHFFGERFGDQMPMPPGAQGHSEERRSLGSGFIISEDGYIMTNAHVVEGADEILVSLNDGRELKAELVGADTKTDVAVLKVDADNLPTLTLGDSEDLKVGQWVAAIGSPFGLDHSVTSGIISAINRTLPRDVYVPFIQTDVAINPGNSGGPLFNLDGEVIGINSQIFTRSGGYMGLSFAIPIDVAMDVADQLRNDGSVSRGWLGVMIQPVSRELADSFGMDKPQGALIADLDPDGPAARDGLKAGDVVLEVDGQTVDSSSALPRLIGRVSPGNDVELKVLRNGEHRNVTVTVGDWPDSQKGAGGSAGDTAPARLGLAVRPLEEGQHDQAIDNGVRVVEVDPTGVAAKAGIRAGDILVSIGEHAVESPEQLSELIGELPEDRAVPVRLYRSGHSYYVALRLAQK
The following text describes a protein:
Function:
Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.
Sequence:
MKGPEKAYLVSDKATKMYSLTLDSSEKNNFSKPPLQDHENPRIKYHCHNNNTKAYDARQKEQALAKKKLCIASLICFIFISAEIVGGYIAGSLAVVTDAAHLLVDLSSFFISLCSLWLSSKTSTMRLTFGWYRAEILGALLSIITIWLVTGVLVYLAIERIIRPDYTIDGTIMLITSACALGANLILTLILHQPGHGHSHAGGKHEHMASDYKLQTNASIRAAFVHVIGDLFQSISVLISALIIYFKPEYKIADPICTFIFSVCVLITTMTVLRDLLTVLMEGTPRGIHYCDVKQSILAVDGVKSVHSLHLWALTMNQVILSAHIATDIVCESKRILKDVTQNVFAIFPFHSVTIQVEPVDEQSPECMFCYEPTQ
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKAAAPQIELASADPSIAQEMTRWLSHLGAERRLSPKTLEAYGRDLRQCLDFLCNHWGERVTLKRFAALEATDVRAFMAMRRADDIAGRSLMRALAGLRSFGRFLEREGKGKVGALSAIRAPKVAKSLPKPLPMASAKRLADADERAGEERETWILARDAAVMALLYGSGLRISEALGLKRREVPKPGEGDVLVVTGKGNKTRMVPVLQNVLALVQEYVSMCPYPLPAEGPIFVGARGGPLSPRIIQLAMERLRGALGLPDSATPHALRHSFATHLLSRGGDLRAIQELLGHSSLSTTQIYTGIDSERLLEVYASAHPRR
The following text describes a protein:
Function:
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2D/RPB4 is part of a subcomplex with POLR2G/RPB7 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA.
Subcellular Localization:
Nucleus.
Sequence:
VLTEQEEDSSQLQFPQEFESAETLLNSEVHMLLEHRKSQNENADDEQELSEVFMKTLNYTQRFSRFKNRETITSVRGLLLQKDLHKFELASLANLCPETAEEAKALVPSLEGRFEDEDLQQVLEDIQTKRSFQ
The following text describes a protein:
Function:
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
Sequence:
MEQGKHLAGLILAVFLLQGTMAHVKEVKVDDNREDGSVILICVTNDTTITWLKDVEQIGSGDTKKNTWNLGSSTKDPRGIYKCEGSNNQSKSLQIYYRMCQNCIELNPSTVAGFIFTEIVSIFLLAVGVYFIAGQEGVRQSRASDKQTLLNNDQLYQPLKEREDDQYSHLRKN
The following text describes a protein:
Function:
Has a regulatory role during midline cell development.
Subcellular Localization:
Nucleus.
Sequence:
MLKDAHQKLIKHRQSTKLSMTDFACQAAPVKQPLPLELPLPLSVQLQLLAKTPTSDHAPMHSTPPTTPPTPPPLPLNMSQSASAVTEAATPENSLPATPPSEGALAVPSAPQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFGMLDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGLRRKREQESDRDLESDQELGGSSPMPRRKQARPRRRSGDVPHDFTLNKTDAESLQTVIKHELLERAERDQEEAPDQDNSQGEAEKISSSPAKTLVERAKEQKSMKEEGSDQPRSLNENHHQLELDDEDDDDQDHEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNPSPCLSDGPEDLCTTKKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGNNGLLTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGSGEHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNLLGPMGMPPFGGHNGGHPGNSGPGNGCPGQAAHERLEESMNRLSKELGKEFGKEFGKEFGKEFGPASPMSLQGPFNAPDGPPHPPSPLPFPGMSSAMTLTPPHMFGLDSPLGLFPPGIDPGKLYNPLMEMSDPRDMPGGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGPPIEMLQMGIGGGSGGSTKNEKSKERKEKEKDKNSMSSNGSGGSANSQGGAPTSGSGPMQHSGELGPMGQLDLDLGLPLGPPGGPRSNSSEPDLLSAPNALFNPFNPQGFYPDFSGGFPGLPLSMLNLLPPAERHHAAAAMHHLGVSMDEDCKSVGSKQSSSVDEDYSGPGIPLSLEHRREISATGPPLTPSNGGTGHD
The following text describes a protein:
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MEGDSYHNATTVNGTPVYHQPLERHRLWEVISIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGVMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTEAEKRKPAHRALFRSCLRCPRPTLAQRERNQTSWSSSRRSASTSGKPSQATDPSTNQAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSRGKESPGEEFSSEDAEETFVKAQTEKHDSDTPNYFLSPAAAHRPKSQKCVAYKFRLVVKADGTQENNNGCHKVKIMPCSFPVAKEPSTKGLNPNPSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MTGDVCPSSRDLERALSLPMVEAFHVSAWYVLQYYEKAIDSSDLLSLRGLITLSLNNLCRSEEAADGIEAFELLLRMALRDAKWLRVRCIETQYSCFIRVASALEELNITPIAKYVISDTRSEGEQLVRVLDGKAIFRPPLGCREEIREILRTARVHELQQLDRCVRYEDGPPSHNHSAVHYTLAGNHSYGGESITGVQTAGRSSWNAKGCSSRLLPEKEDLIDRILSVSDEEGQLASAWDRTVGPICCVHQLFRDSILKISELIHEVTAPSIRDDICKYPGSAPAGCRSSDTTILKIVSKLMLRQSSDLRGPWMLWPQACRIVGGESSGGVVPLLASSPKALVSFREAIELCQRLCELRHAKTLKQCSADIVLEYHSTIEKKLALLDSRPLTADDCADETARRKRTYSVTTSADVSDGCALSVEELLHHGGLLYEHLLHFLPKYRWFACAELLVPLLQAHKRWDLVNMWLRKLLDEPVYVVSTSFGTPTFPMYYRYEKRGKWWNLLAQGHAHLGDKEGAFQLLEKRQSAWREQDSPQRYLRMERAEELPVSIQRRARLLCALFRVGRGRNSGSQKAVALYNAVGEHHRLHFYRRSDRIAIERTLLSLQSFLRRWTPTSPNLSSFTAHMLSAPETTIPGDKDHSDATFWGDTKPSTGCFSAEKCVLRWFGLPKVHESGDGTCRPSSWTGLHCKGRWVNYLGRLLLWDAFHFDPDALPRGNESMTGSVPEFVWLSPVQETPLDLETSSISFQQRRRHIIEKSLRFFERCSRDVLIYYVRQRCVSENSGACEDNSKQKSNSSSLKEPLHANDVGADFISGDENFVPLGQPVRSPNSQEKDGPTASFIPAEQLLDPEEFPLFDLLQAVPQGALCALLRCLYLPPPEDGYSVHFDSFPDLVLWREVPSQPDGYEFKLVEVLGPNESLSEKQISTIDTLLRCKFDVTVAHVTDVDEGKKKSNRSKGRHDGTEHGRGRNRQDGAHPPV