lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAVEEAQFWQAIGILIKNYHALNKKIFEVVITQVTKQQNGRVCESSAEELAMSLKEDPSQRTCTGFTIGFKLLSKKLAENILGTGIVDFENCLYECQFASDSIEGFSVGLLGGEFKLKSKSNTNWLEFVLRPKLLSWSQSKQDEAKVKSLGLVNVEKYNDLYKELKQRHSQRLLEHWKTAQESTDPLKFIYEDLAIAAYLIVLWSQTQSEPTAFADLGCGNGLLVHVLNAEGYKGYGYDIRKRKLWSLYPPDTQRSLIEKAVEPNSFRLDFPGVDWLIGNHSDELSPWLPVLAGRLNINYFLLPCCPFELSGAKFRRRNTKISAYQDFFQYVTQVSHECGYEILQDRLKIPSTKRLALLGIKRKASKAIEDLEYFVQEELRKYKTGDAKIKLREKEESVRNCTQVDKTIIDGLVFKIFKLILDSNEDKWSGRLPMREIAQALTKEELSGIKSECGGIKTLLRNKHEVFEFCGGDLIGIRTPKPTATLPKSHLTIKKRSCFFKLHHPLGCPLDDAECSFIH
The following text describes a protein:
Function:
Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.
Miscellaneous:
MISCELLANEOUS: Present with 3240 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MELNDPSIISSSQFSGELSDSDTAAATHKSQQAISNLFQKLAKKGREEKPIGSVESSTDSSNISVATSGNNKESNKKKNKKTAMLNFSSLTDPITNYKPMDLQYKTYAYSMNELYHLKPSLASASYEEDPLISELVRSLPKRKFWRLRMGPPDQKHANNHHFNGNNGGGSWKAGYKNGKNDERRMSRTKNMQGGKRRSQQDDEEKKIDQEMLEMDKNLQLGGDVGHSIADFEDWKAKMKELELKKLSKSKGISNSTAIAPRESASHETPTDLRPVIPRGPSSITDFLNLKRQDKKEESSQQTPGIPVGQPSLSKTSIEQVNELETNSDLGKSSSSRFSSFFNKSATSLPSLDNNNQVPSSNVSVVNNDGNSTPHQSGSRLMSFFKESRSSTPNAESQLLSASDKDNGKMQTLPQFQQQPQQMQPMAFTQHPPNNNAFFNGLLNKGKSETSTPPPPPPGLIAHQGPQFPVMGVPPNFPQRMMPPPPGLVQFQKDSKDVNKKEDRQLRQNKNPNGTRNSKGKQEETATPDLPQQQYMPPPPPPGFFPMHPNFPNGPMPPLPQGFPIPPNGMLPVTGQQPQPPYPNMMLQGNFPPNFQQGFGSNSPMPIPSIINANGKNVTNQLPPGLNSKKNIK
The following text describes a protein:
Function:
Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Plays an essential role in cell division during embryonic development. Required for the assembly of the synaptonemal complex between homologous chromosomes to promote sister chromatid cohesion during mitosis and meiosis. Has a role in stabilization of homologous chromosome associations during meiotic synapsis. Required for chromosome segregation during mitosis and meiosis. Plays a role in DNA double-strand break (DSB) repair during meiotic recombination and promotes the assembly of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, at DNA damage sites.
Subcellular Localization:
Nucleus. Chromosome. Note=Has diffuse nuclear appearance at interphase during mitosis in somatic and germline tissues. Localizes to chromosomes at pachytene during meiosis.
Sequence:
MSETPTDQSPQRMSTRNQARVNYTDMAAGNNSVEKEPVFRSPTASTRGRKKRAANVDVADLSASFGNLNNFSTPPKRGRPRGGGLGSARGGRAPMVRRTTTEESAEVDDRELVAAVKSGKKITEAVDRWIGRYNEKFLVAIAEMHQFFFAICGCKGIVTPQMSATLTYKDIICRMTEDFEEDSADYPLVHGGSLKKVRANLHNFIHTLIIRTKASMLFDSNLMDGFVQLLTGMADSQVRAFRHTATFCAMKITSALVDVTIELTQSKEKTSKQIEAEKAKLKNNSAGNEKYEALVAQRTQTEERAEEIRQIIGYLFRSVFVHRYRDVVPDIRCICIQELGHWMDVYPEHFVEDSYLKYIGWSMFDKVGDVRQRCIRALIPLFEKTLILDKLELFVNKFKDRLVSMLLDKDLETSIETVHLMRVLYTVFPTLLTIKDVVPIYELIYASNRPLAVAAGMFLNTKVFRSAEKPGKAPTAANIPLVKDLTTFFIEGDLHQHATYLVDALFESNPIVKDWATMGELLINDQYQLDSNFETKLIEILTCSVVQSATGEPPVGRHIVKKGAPSAKESRDLVEDRQRLTETLIPLIPRLITKFSSDNEKIINLVNIPLHFQLETYLSARMQTHLMELMEGLDSLIEKHLDEELLKAVAELYYHLTTNSSISALVEGHKMKLLDGVAAFIRKSMQQFDDDQMGEEEEALFVSYIKRMAAFAGFMDLRHWDLWDILLKVVSNYTREDTQRDVRERSMQMLFMQLCFDSMNIKKEGETPKADQVRKLKKRRDQLIRIVTETLNEEACGVEQAYLVICDLMILFGSQLAEESKALEPLIWRPDAMVLGNLKIFLDVNVFDVSNLDDMDQQEKIEVMHKMRQHVAQYAKLIIHGAMPVAEASHLIKRYQSHFQDFGDIFKNLLSKCREISFVETGVMICETLKTLYSQLDEDQGTDPLSESFNSIRDLAKRLGPAFGVDYAKNRFAISSLHKKAIDFAFEEYDKENHQMPKNIFFLEIAIEFSGKLLAQDKMAVVRYLNKIYTNRVGTSTVVWEPYRLYLGSLSDRNDDDNMSVRSGMTVTSNATMRSTASSTRGRGRGRGRSRIADDF
The following text describes a protein:
Function:
Transcription activator that binds to the ABA-responsive elements (ABREs) in vitro. Involved in abiotic stress responses and abscisic acid (ABA) signaling. Involved in the signaling pathway that induces growth inhibition in response to D-allose.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing BZIP12 exhibit increased sensitivity to D-allose-induced growth inhibition.
Subcellular Localization:
Nucleus.
Sequence:
MMASRVMASSSPSHTASDLARFAAGRGGGGSAGLGSMNVEEILRGIYADMPTPALPLVGGDRPMSPLPAPDVAAAPRTAEEVWKEITGAGVAAAAGGVVPPAAAAAAAPAVVAGAGAGTGAEMTLEDFLAREGAVKEDEAVVTDPSAAKGQVVMGFLNGAEVTGGVTGGRSRKRHLMDPMDRAAMQRQKRMIKNRESAARSRERKQAYIAELESLVTQLEEENAKMFKEQEEQHQKRLKELKEMVVPVIIRKTSARDLRRTNSMEW
The following text describes a protein:
Function:
[GLV2p]: Signaling peptide (root growth factor) that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells. Also involved in the regulation of hypocotyl bending and root gravitropism, probably by influencing the formation of auxin gradients. Maintains the postembryonic root stem cell niche.
Miscellaneous:
MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
Subcellular Localization:
[GLV2p]: Secreted; Endoplasmic reticulum. Note=The precursor is detected in the endoplasmic reticulum probably during its processing.
Sequence:
MAIRVSHKSFLVALLLILFISSPTQARSLREVVRNRTLLVVEKSQESRKIRHEGGGSDVDGLMDMDYNSANKKRPIHNR
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular Localization:
Nucleus.
Sequence:
MAGIDNKAAVMGEWFDCSTTNHRKRSKAELGREFSLNYIKNEDSLQTTFQESSRGALRERIAARSGFNAPWLNTEDILQSKSLTISSPGLSPATLLESPVFLSNPLLSPTTGKLSSVPSDKAKAELFDDITTSLAFQTISGSGLDPTNIALEPDDSQDYEERQLGGLGDSMACCAPADDGYNWRKYGQKLVKGSEYPRSYYKCTHPNCEAKKKVERSREGHIIEIIYTGDHIHSKPPPNRRSGIGSSGTGQDMQIDATEYEGFAGTNENIEWTSPVSAELEYGSHSGSMQVQNGTHQFGYGDAAADALYRDENEDDRTSHMSVSLTYDGEVEESESKRRKLEAYATETSGSTRASREPRVVVQTTSDIDILDDGYRWRKYGQKVVKGNPNPRSYYKCTANGCTVTKHVERASDDFKSVLTTYIGKHTHVVPAARNSSHVGAGSSGTLQGSLATQTHNHNVHYPMPHSRSEGLATANSSLFDFQSHLRHPTGFSVYIGQSELSDLSMPGLTIGQEKLTSLQAPDIGDPTGLMLQLAAQPKVEPVSPQQGLDLSASSLICREMLSRLRQI
The following text describes a protein:
Function:
Kinase that phosphorylates myo-inositol to produce multiple myo-inositol monophosphates. Participates in phytic acid biosynthesis in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Sequence:
MTLNPPPSQQTSHSPRRIPNRRVLIVGNYCHDVLIQNGSVVAETLGGAASFISNVLDSSSVSCDLVSKVGHDFRYEVTHSPIVAPEKETTVFEAYFDLGIDGIGHADRVLKRVSACDPILPSDIPDSRFDFGMAVGVGGEILPETLEKMVEICDVVAVDIQALIRVFDPVDGAVKLVDLKESGFYHILHRIGFLKASSDEALFMDVEQMKHLCCVVVTNGEKGCRIYHKDDEMTVPPFLAKQVDPTGAGDSFLGGLIVGLVEGLTVPDAALLGNLFGSITVEHIGQPKFDLMMLQKVKDEVQRRKKQCNISSSHNNDHNEFHERLSPARFSCVDSQLQPKLLVNGHSCDDRSL
The following text describes a protein:
Function:
Water channel required to facilitate the transport of water across cell membrane. May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Trafficking from the post-Golgi compartment to the plasma membrane is mediated by the SNARE proteins SYP61 and SYP121.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MSKEVSEEGKTHHGKDYVDPPPAPLLDMGELKSWSFYRALIAEFIATLLFLYVTVATVIGHKKQTGPCDGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLVRALGYMIAQCLGAICGVGFVKAFMKTPYNTLGGGANTVADGYSKGTALGAEIIGTFVLVYTVFSATDPKRSARDSHIPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWDDQWIFWVGPFLGALAAAAYHQYILRASAIKALGSFRSNATN
The following text describes a protein:
Function:
Involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPKFKGPGLSVLKKKIRDNERLLKKENLPANIRVEHERALLGLQEQLSMAQLEHKKQKIFERYKKVRFFERKKAERRIKQLEKSLKDETMDDEKRKQCEKSMRKCQIDLMYIKEYPPLTKYVSLYAEGTSEQTEETRNRIWAEMEERFNSGRKHKIPSSGSNRVPVQEKSSTGGDLEDEFLQR
The following text describes a protein:
Function:
RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development.
Sequence:
MPSKLFVGNLPDNVDSNKLKQVFQPFCKVTECDIVKNYAFVHIEEDDVDPIITRLTGYTIDGKVVNIKKSTSKLRPTPGMPNRCFRCQSDEHRTPQCPQDPTNNQKTENGVQTLKFDLTSGAGVKRSAGDPIIDSAKRIAYGAQSVVEPEIPQPMDPDLQALYQEYQLSRQRYVYYRDRLLKEMEAKQHGSTAGFALSSSSTVPVPVASAPPGATQLSAAPVSYQPNAPPVIASINAPYAVASNLRAPYALQSAPYASAASAPYGSVTPAGAPSNVMTTQQYLQQIQHQQATGSPAPVPAPPRLY
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MHFSGFKSVVLSCVEEYFDTTAVAIVQYLMEVAFGTLNDLVTAVRLPPDIIKTSMMALLRHNIAFFVELPVIRNGHELSRKHMVYGVFSEQAMVRMFCPIVLPRVSDLDGLGDQLLAALTLGGSMTAPEILEVLRTMGVDVGLPRLLETLSTLLSRGVVQRSSELRERCQNLLTSVYYAHHHQSHNVKGPESTEPPRKHSHGLHSLESDNVSDSGESYCVSVEQLIALFQEEELADYVCTVYDRDMGTVFRAALFISNSFQALGFCPFSPADVRPSTRSFNLEQLHDALMNAQYSLNATGSNFTLSFCASVLKLYVSEPKAMMHMTSDGQYIVDIDAAIERMQMAVLLRIVAERHGPMARRMFNIIRARGMMEASVVAAEGMIPRSQAVSLLTTLCTEGYLQITMLSTSAEPKVETSYFLYSTNPNFSSVAANAAFTCLYNMRSKLKQIEELQFTLLASNQVQRINDQIDLIEPIYIKLVETAMLLF
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MADTGRSPRPTAGGVRQRKGGATAAPARARGGNNGGLWRFYTEDSTGLKIGPVPVLVMSLVFIASVFVLHIWGKFTRSRA
The following text describes a protein:
Function:
Involved in reproduction of the worm (By similarity). Involved in host-parasite interaction (By similarity). Delivered into the host cell by means of parasite exosomes (By similarity). Binds to acidic phospholipid membranes in a calcium-dependent manner in vitro. Causes aggregation of liposomes in the presence of calcium, but not in its absence. Likely to promote membrane fusion. May provide structural integrity within the tegument.
Subcellular Localization:
Tegument. Secreted, extracellular exosome. Host cell. Note=Mainly locates on the cytoplasmic face of the dual membrane of the tegument. Associates with the apical plasma membrane and its derivatives including surface invaginations. Localizes to vesicular structures, such as the elongate bodies, and to muscle layer, within the tegument.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
MANISGFGITRSLIHSFDPHGKHYRPTIKPTTGFSASADAERLHRSMKGPGTNELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTSGDFRKVLCQLIVDTPYMLAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLKDKGSEESERSLVTDMKKETCGDYEYALLSLVQAERDDIPILQLKAIPDKGVNSIINHELAEADAKDLYASGAGRVGTSERRITRVICNRTPYQLYLTSEIYFKMYGKTLLEHIESETSGDYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSEIDLQDIMDAYESIYGKSLLNAVKDDTSGDYRRTLCVLMGEIYNQQQ
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MLKILPNQKKKKKTQQFRLKPEQITDPQKGVVYLYNLCKDYRFGNDELDELNKYMHVIEEWHYQIMPKYDFDYFTNRLQKFGGNNSVQTHLQFLRKAHKGLIPWHFVLNPLGEQPINDQTINQTFSETIANNSVIQEEQHQQNIIQHDQNLSQPDPQQNNSTTVSQKKPLKLSLKKQNTQQSQVKSVKKELTVRFNDEVQYEPSPKPIQVDENFDDIFEQLEAAYKIKEEKKLIN
The following text describes a protein:
Function:
Receptor for the neuropeptide CCHamide-2.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYASLMDVGQTLAARLADSDGNGANDSGLLATGQGLEQEQEGLALDMGHNASADGGIVPYVPVLDRPETYIVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVMIWILAILLGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRDPEYAKFMVAGKALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHFYPTAEEDFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFNRYLCCICVKRQPHLRQHSTATGMMDNTSVMSMRRSTYVGGTAGNLRASLHRNSNHGVGGAGGGVGGGVGSGRVGSFHRQDSMPLQHGNAHGGGAGGGSSGLGAGGRTAAVSEKSFINRYESGVMRY
The following text describes a protein:
Function:
Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MSYSYPFFDDVYAYYNQTVTFFGKALDVLPGSPIVKRYIKSSYQNDPLRTFIEFLLLVFAAYYVLRKPRTSPDNNYVEFTEKEINELVDDWKPEPLVAELTDVEKLELKSIPVLESVHLHTKLIDGRPITNFASFNFLDLAENKHITECAVATLRECGLGACGPPGFYGTQDKHLRLEKDIASFIGVERAIVYAQSFQTISSVIPAFSKRGDILVVDEACNFAIQKGIQISRTTIRYFKHNNMKDLERILQELEDDFVKHNRPLTRRFIITEGISENYGDMVDLTKIVALKKKYKYRLILDETWSFGTCGRTGKGLTEHFGVPPTDVEIIIGSLTTSLAGGGGFCAGSELMVEHQRLSGMAYIYSAALPASLAVAAYEAISILSRDGGSMLNDLRSKSALFHAKLSRNKFFETSSDIESPIIHLRFKDKDISHDKQVFLLEEIVELCIAEGFLIARAKRVESLERVKVQPSLRICISTGHSAEEIEKLALLIKEKTEIVFDKHKVINQV
The following text describes a protein:
Function:
Determines thylakoid architecture by inducing membrane curvature.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MELCTRSTTIITHLPASFNGHGYLAGKSVDRISLPLQRNVASLVLQSRTLRCSRKFPGETVTEETSTGVNEFGVEDRDGVVVAAEEKNSNSEAPQAEDEETQALEFLNDIKLDSDKTYSILLYGSGAIVALYLTSAIVSSLEAIPLFPKLMEVVGLGYTLWFTTRYLLFKRNREELKTKVSEIKKQVLGSDSE
The following text describes a protein:
Function:
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MVSDIIGVSPKQEAPFKRGPSRFSTQNKSEEGHRRRANQRNRLRTMEGQCSVPMIISGHTEAEQPKSLRGKPSSRIAAVMLAVILCLATAAAAVLFFSSHTKHPEVHEDSFHLKLRQISNVRAAIHVEGKYNPSLDTSIEWIRGVDQFHFQGGLDLDNNEIVIPRKGLYFVYSQASFEVSCSGDASSMVQLSHTVQRWSSSYGREDDKTYRTILHSIRTACQRKESDEQDANGDWYTAVYMGAVFNLEKGDRLRTVMKKSMLEQLEDNPGNTFFGAFAL
The following text describes a protein:
Function:
Acts as a transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MADHLMLAEGYRLVQRPPSAAAAHGPHALRTLPPYAGPGLDSGLRPRGAPLGPPPPRQPGALAYGAFGPPSSFQPFPAVPPPAAGIAHLQPVATPYPGRAAAPPNAPGGPPGPQPAPSAAAPPPPAHALGGMDAELIDEEALTSLELELGLHRVRELPELFLGQSEFDCFSDLGSAPPAGSVSC
The following text describes a protein:
Function:
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).
Miscellaneous:
MISCELLANEOUS: All three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase.
Sequence:
MPRLASAVLPLCSQHPGQCGLFPLEKSLDAFAARYRLAEMAEHTLDVQYYIWQDDMSGRLLFSALLAAAKRGVRVRLLLDDNNTPGLDDILRLLDSHPRIEVRLFNPFSFRLLRPLGYITDFSRLNRRMHNKSFTVDGVVTLVGGRNIGDAYFGAGEEPLFSDLDVMAIGPVVEDVADDFARYWYCKSVSPLQQVLDVPEGEMADRIELPASWHNDAMTHRYLRKMESSPFINHLVDGTLPLIWAKTRLLSDDPAKGEGKAKRHSLLPQRLFDIMGSPSERIDIISSYFVPTRAGVAQLLRMVRKGVKIAILTNSLAANDVAVVHAGYARWRKKLLRYGVELYELKPTREQSSTLHDRGITGNSGASLHAKTFSIDGKTVFIGSFNFDPRSTLLNTEMGFVIESETLAQLIDKRFIQSQYDAAWQLRLDRWGRINWVDRHAKKEIILKKEPATSFWKRVMVRLASILPVEWLL
The following text describes a protein:
Function:
May play a role in hearing.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
THSFRLSRLSSWRVHVGLVSHSTVRPHQGAVVERIIAHPLYSAQNHDYDLALLQLRTPLHFSDTVGAVCLPTEEQAFPRGSQCWVSGWGHTDPSHTHSSDTLQDTVVPLLSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCLDGDTWRLVGVVSWGHGCAEPNHPGVYSKVAEFLDWIQDTAQNSLH
The following text describes a protein:
Function:
Catalyzes the sodium-dependent transport of glutamate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEEINVLKFDMFTTLMLAVLAIYFGDFMRKIFPILKKYCLPASVVGGTVFALISLLLFKMGIVQLDFDYKAINQLFYCIFFAASGAAASMALLKKGGKLVAIFAVLAAILAACQNGMALVVGKFMNIDPLISMMTGSIPMTGGHGNAASFAPIAVDAGAPAAIEVAIAAATFGLISGCMLGGPFGNFLVKRFKLEGSTSNEQAMGEIDAEGESGNLLVDKPNIIQAVFLMCIAIGIGKIIELGLKSIQENTGWKVALPIHVCCMFAGIVIRLIYDRKEGNHDVLYESIDIVGEFSLALFVSMSIITMKLWQLSGLGLALVVLLIAQLVLIVTFCYFLTFRLLGKNYDAAVMAVGHMGFGLGAVPVSMTTMQAVCKKYRYSKLAFFVVPVIGGFISNLTNAVIITKFLDLAKDLHTIWIS
The following text describes a protein:
Function:
Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
Subcellular Localization:
Cytoplasm.
Sequence:
MSQEYHVTSLVVHAAPNALQQVEADITALKGCDIHAISPEGKLVITLEGDSQKAILDNVEAINALSGVLSASLIYHQVEPLEQELLEKMSEETL
The following text describes a protein:
Function:
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNYKNLNELENFKILEGIAPEVLKTALTGKRIKEYDITIEGDSVHYNYASKQINETHLKIFQNLSDEANLIEKYKEVLDGEKINISENRKVLHHLTRGQIGKDVIEDNKENMREFFQSELEKIYNFAKQIHSGNIKSSNGKKFKNVVQIGIGGSSLGPKALYSSIKNYAKKHNLALMNGYFISNIDPDESEEVLSSINVDETLFIIVSKSGNTLETKANMQFLINKLKLNGIKEYKKQMVIITLKDSMLAIEEKGYLEYFFMHDSIGGRFSPTSAVGLTLLTLCFTEKVAKEILKGANEADKKSLNKNVKDNASLLAALISIYERNVLNYSSNCIIAYSKAMENFYLHLQQLEMESNGKSVNRFNETINYKTVRIIWGGIGTDVQHSFFQMLHQGTDIVPMDFIGFNETQLKEDVISDNSSSNDKLKANLIAQIIAFSKGKENSNKNKNFQGERPSALIYSKELTPYAIGAILSHYENKVMFEGFLLNINSFDQEGVQLGKIIANQILKNDNFKDEVIESYSKKILKKF
The following text describes a protein:
Function:
May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing.
Subcellular Localization:
Endoplasmic reticulum membrane. Nucleus inner membrane; Multi-pass membrane protein. Cell membrane. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen.
Sequence:
MAANYSSTSSRKEHVKVTSEPQPGFLERLSETSGGMFVGLMTFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKIDNFKALSLAKLEDPHVDIIRRGDFFYHSENPKYPEVGDVRVSFSYAGLSSDDPDLGPAHVVTVIARQRGDQLIPYSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWAALIGCLALVPIIIARTRVPAKKLE
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRHHQKKSSASGGGSQRQLRVGEQVRHAMAEILAQGNVHDADLEGHIVTVPEVRMSPDLKLATIYVMPLGGRDTEIVIAALERNKKFLRGEVARRVNLKFAPDVRFRVDERFDEAERIEKLLRTPAVQKDLEQDPDSDREEEQ
The following text describes a protein:
Function:
Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MYRRSYVFQTRKEQYERAEEASRAAEPDSLADGRGAAPGLVALQGLGERVAAHVQRARVLEQRHAVLRRQLDAFQRLDELAGPEDALARHVESNRQRVRDLAAERVRLERQGAEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQIEAQFLQDDISAAKDRYKKNLLEIQTYVSILQQIVQTTPQVSAITSGMREEKLLTEREATALQSQLEEGREMLSFLQAQRAELQAQTATLEQAIKDAHDCYDGEIQLYNEQIESLRKEIEETERSLEKSSYDCRQLVVAQQTLKNELDRYHRIIENEGSRLSSAFIETPITLFTLSHGASVSPRTGGKDLTRAVQDITTAKPRQKGLPRNIPRKKIIAKDKAEESLEDAPPKDPEDTKLVQVVLKEEGESKLESGSEEASPPTPEGTPEDVPDGGQISKAFGKLCKMVKERVRSPQEPEPPADLCTEEQHVLVSGDASYVNPEFCSFSIPARGQVVVSTEDDSVRRDSHAEPSPEQPKPPLEDGQGDSQGGEEGRPPNQHPAEKEGEISAEELKDTGEKHDGQREEEESQRPCPVVTPGPEGPSTPPSQSSVVSEGGSEGSGAQSSSLPERGPPRTLAYEKVQVVESIEKFSTESVQTYEETAVVVETVTGKTKAKKKLGETGS
The following text describes a protein:
Function:
Acts as a negative regulator of transcription. May function as a switch in neuronal development (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSKPADHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDHLKGLPVSATDSLLGSSEKARAFLPPTSAPYSFLDPSQFSSSAIQKMTEMPHTLATSTLPYASSLGYQNGAFGSLGCPSQHTHTHPSPTNPGYVVPCNCTAWSASSLQPPVAYILFPGMTKSGIDPYSSAHAAAM
The following text describes a protein:
Function:
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subcellular Localization:
Membrane.
Sequence:
QSQVCVFTVCKNLQKGPSQQMALLTPSPKRSMPKAHLTAAKMETTAKLENILPWESNLGNAFTDSGFAYTDNALLIPESGRYFVYAQVTFRALMHDHGKRGCEPVRLSQTISKMTNGYPTPSDLITSFKTVECGSDTWMKSLYSGAVFLLEKGDKLMVLVNNITLVDFTDEKKTFFGAYLL
The following text describes a protein:
Function:
Capsid protein VP2 self assembles to form an icosahedral capsid with a T=13 symmetry, about 70 nm in diameter, and consisting of 260 VP2 trimers. The capsid encapsulates the genomic dsRNA. VP2 is also involved in attachment and entry into the host cell by interacting with host ITGA4/ITGB1; Capsid protein VP3 plays a key role in virion assembly by providing a scaffold for the capsid made of VP2. May self-assemble to form a T=4-like icosahedral inner-capsid composed of at least 180 trimers. Plays a role in genomic RNA packaging by recruiting VP1 into the capsid and interacting with the dsRNA genome segments to form a ribonucleoprotein complex. Additionally, the interaction of the VP3 C-terminal tail with VP1 removes the inherent structural blockade of the polymerase active site. Thus, VP3 can also function as a transcriptional activator; Structural peptide 1 is a small peptide derived from pre-VP2 C-terminus. It destabilizes and perforates cell membranes, suggesting a role during entry; The precursor of VP2 plays an important role in capsid assembly. First, pre-VP2 and VP2 oligomers assemble to form a procapsid. Then, the pre-VP2 intermediates may be processed into VP2 proteins by proteolytic cleavage mediated by VP4 to obtain the mature virion. The final capsid is composed of pentamers and hexamers but VP2 has a natural tendency to assemble into all-pentameric structures. Therefore pre-VP2 may be required to allow formation of the hexameric structures.
Subcellular Localization:
Host cytoplasm. Virion.
Sequence:
QTQQIVPFIRSLLMPTTGPASIPDDTLEKHTLRSETSTYNLTVGDTGSGLIVFFPGFPGSIVGAHYILQSNGNYKFDQMLLTAQNLPASYNYCRLVSRSLTVRSSTLPGGVYALNGTVNAVTFQGSLSELTDVSYNGLMSATANINDKIGNVLVGEGVTVLSLPTSYDLGYVRLGDPIPAIGLDPKMVATCDSSDRPRVYTITAADDYQFSSQYQSGGVTITLFSANIDAITSLSVGGELVFQTSVQDLVLGATIYLIGFDGTAVTTRAVAANNGLTAGTDNPIPFNLVFPTNEITQPITSIKLEIVTSKRGGQTGDQMSWSASGSLAVTIHGGNYPGALRPVTLVAYERVATGSVVTVAGVSNFELIPNPELAKNLVTEYGRFDPGAMNYTKLILSERDRLGIKTVWPTREYTDFREYFMEVADLNSPLKIAGAFGFKDIIRAIRRIAVPVVSTLFPPAAPLAHAIGE