lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1.
Subcellular Localization:
Nucleus.
Sequence:
MSHIDGDDHMTKDLIDSLESKDNDLSLVTSNTQIPDVEVANLTHDADEINQLFDTATNNVLPESNKKDKPIDTQDLHEDDPKAVPKTTSNGESTSNSNSVSPKLLPNDGKSTPKIQKELRRKSTFVPVTSNSKSLEPSEDDNNNNNNNSRISAYARLDFENFTFFVQTLQVVLGRKSNDETLQQNVDVHLSSKKAISRRHAKIFYNFGTQRFEISILGRNGAFVDNVFVEKGLTIPLTDGNKIQIGDIPFKFVLPSNEPNEENNNQDSSEKQFNPSDAINLRSNLYSKSSSPQSSPKRKPQPSKKVKKEPVSASNTSKDIKPTPPVPTTAISPTASISTSTNAATAATATTPATTTAARKNSINRRNSLLKIRRLSNARRKSLAANDEINELLKDLGVTSIDEINEEDSELLDAQIQSLLDEDNENLGGIEDSLMKLAEFNESAIDDDDDDEEGNENSQADLDRLEKTMEHDAIDDEIKAIDSNLTLLDDEISKLTPLINDTNQGLLEEKETKKKQLEEEKRKKQLQQLQHKNSLAKFPRRSAPLMGKPASIQPPASSSIYSRINGLDKIGKTVSPRPPPPKLIAPVLRVTAEPSAIRSRPPLRAITVSDSSYIATFSYPKTIEEPSKYPKPKVKKEHHKKHSKKVYSLDEIPEPYRSKPNISFQIMITNVLKTEAARNGLIINEITEAIKEVYPYYKYCTDGWQFSINHCIKFTKIYKRLQKRGSEWLYAMDELYINERENIRIKQREIAKAKAKAEALRQEEIRQRQRLEAQKSLPHNIVGRNFASPYANTRVPPNQYNQFSQSSSSSSSSATTTTNGQYGSTTMVGGTSPQAGSIRAQLAAVRGNGNTPATTSTTPSLPAMNDPKTKKSLEYLQKELFTLYKARKLTYDTQTATSLITKAVATTIAQVNSIGAKAGAGDNALVFLVERAPEKVSKILDIALTKSIKEHEGIASKSPSQPATPGMRPEQLTTTSQSAATPTTTPQISNLQSLPVKPPISTPLPQVPQQQVSGVNIPGPIATPNIGVTSGVGNLGTTSIGTPTPTQIQSPATSVIPAMQSPQKPVSTPIPTSVPVPLPVPSAPLARPPSFGKPPGAGSSLSRPKAFGKPPGAGSSLSRPPTFLSNKPSYKRELEDDEEEGEQATNKIAKTE
The following text describes a protein:
Function:
Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity.
Miscellaneous:
MISCELLANEOUS: The proteins lin-15A and lin-15B are produced from a single precursor mRNA with non-overlapping transcripts where lin-15B is the upstream transcript and lin-15A is the downstream one. The precursor mRNA is cleaved at the polyadenylation site and a 22-nucleotide SL2 leader sequence is trans-spliced to the 5'-end of lin-15A to allow its translation.
Sequence:
MQTLKTARLTSNPASIPTSSSSSAISAAAIQKTLDAVNRPPAVRASGILRHRTLPAPTQETAHHLDADPKTTELMARFFISQGIPFECAHEPAFLELMKHVDPNCVIPPTNVTKKLVDKISTSSKPQVNYTKTVGPLSVTIDICGDEDEKYLAFSIHYFEDLYERKNAIYLRKLLLTELDSNSLLTNIRRSVNSYSFSNVKFTNIVCPNEEICKLVEESAVVKRYNVCFYNYVTRFVADLMEIEEFSSGLTQLRTFVRYMKQNSDMYSKFRRMQLQKNAELDIPSIDSGDWHSTAIFLTRCLVWHDTFTEFCGKLDILHYIDNETFNHLIYLQRLLQQCMKHCRELSIPNNSISQVVPAIMSIRNFIASNSMGYRFQKRIRDSFTTSFKEITSGPSQDRYDIATLLDPRFAYRDTVYTAQTWRSLEKKVIDDFVNSDLQNDKNFYQDISILNQEQRYDIIKKEFAYYRQTSFVERPEENENSNHWWGMRQTDMEFLAVIAREYLASPAVSIDAGYYFGNGGKFQHICHTYSHQRLENCLALAGNYQTFRGKGASVDVISQSMIETLNNTASRLQKQVHLGLYAHGVDNISSDRDVQSIVGHHYPPMPTVANYDIPHVPKEEEKPPVANLQSTSSPATSSPTIIRPRAAPPPRTLAQGRPIPLNGKELKAVPIRQIPLQVRPLPPRPANVPIVPRPTVPQQFIKAPAPKPITLQAVVCSIPEKEIKKETEDVALLEKIKDEPLDEDDFNHPSTDPVPNRTTASSQGPSSYPRKIVVLASKLPTSQSSSPSTATSAQARSHVTTAQLIRCGPSEGTVPQKIHSHNFVQKFAQKQNFVHKYALNSQDHTGRLNQTVPMRAALRLPNSEQKSGAPSSINGKVQRDDFKLEPLDDFNGEPDYDNLIGAQRLMYSDNLNDASAEDAFARHRVTMEFQKRRACNRRCAVCGHLEIHERLKNVTIENEKLLIMLGCIYRGEFTLGQAQLFMARESKTYICRLHFLETLDEIYQMLRLKSADDILICPLDLIQNALITVSALRPHIIASQLRKILHDFAERNNHLRETPAELKKLGQQYFDYREPEPEPERNDVDEQEIIPKLFRQPRKQVLEADQHDGTVKVIEQEDFKLPTVKPSENEECDNPGVCCFCSKRGDRGGMLRVPRSEERLARWVDKLGPEFEARLHTNTENLICRSHFPDAAFSSRGRLLKGMIPDAAPEKVETTYIIQGNNFLKLKERKSGTDKNSAIDLANMLNPDGVEYTQEEEEEEEYEEMSRSPTEETSDDEPSQAAVYNNAPVIKRTYRKRELSNEDGPLNLVTPPAHTPNPRGRPRKYPKNSVTPEAEKSLTDYDYNPGTSQRRALKKGYVQLEDGEIVGEDCEYVPEKTPSGRLIRQAVARRSFAFADEEEEEEEYEESPIVKKPKIAGRPVGRPRKDANKLPTPTPPSNE
The following text describes a protein:
Function:
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
SNMFGFFKKNKLVKLRGFGSNQKYGMAATSVKELLKKGCETLQVPHSGSRVCLYEDGTEVSEDYFKKLPDNTELILLAAGQTWNGFVCDVGLLLGASDLHTELLIESARGLLTDEHAPKRRKILQELLHNLKETSDLESREEDEDWFEGVDSRFKTKSAYMKYNCENRVRGYLKEVDGYTQHIKCPRARGEYKKTVDMMTEKLKAIKYNGCYFDRKEKEPNRLCTEEGWFSCQGAFDQDECLSLHSINPYGNRESRILFSTWNLDHRIEKKRTIIPTLAEALKKHKSSEINLDYFYRLLFTRENLKLVHIVCHKKSVHDLVCDKNKIYKKGKRRIK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEAPAQKAGQGGLPKADAQGASGAREKRPEEPRPLEEDRAGSRPTQKGDLRGAAGGRTTPPGGGSRGCSLGVSPGPGTRHSAGTRPLVREPCGPTSSQNPELVIPEGLQAREGPCRSPARGGDCSRNSCLAWHRGAPAGETPPVCDPCPERIQNHPRTQLCEVHTDCWPCQPGTGAPTCPRTPKPTSRGRNPLVEQPRACACGEAFAWRALRIPQERLQATEEPRPCARCGKRFRPNQQQQAGKSPPVCPECGQTSRPRPIVPDPPAQRLYACDECGKAFTRTSSLLQHQRIHTGERPYECAECGKAFVRCSGLYRHQKTHSAERHRRGPVLARRAFRLGCPPCGDYSERSPRRGSGAGEKPYECADCAKAFGLFSHLVEHRRVHTGEKPYACPECGKAFNQRSNLSRHQRTHSSAKPYACPLCEKAFKGRSGLVQHQRAHTGERPYGCSECGKTFRGCSELRQHERLHSGEKPYICRDCGKAFVRNCSLVRHLRTHTGERPYACGDCGRAFSQRSNLNEHRKRHGGRAAP
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
Subcellular Localization:
Nucleus.
Sequence:
MGRTMIQVSFSWIRLPSKVRSLVHSLLLVALMSLYADPLVVSASGSVTSKELVKNLSAEPVHAATNSQGLQRRQNGPNPPRRTDGHGSSAAIYASFISAVTGALSLQLIRCNKAIPLGSRTLFTVVAEDYYDNPRIDNDNPAAVPSLTTLQIQLTSLGKLTVSLQTISQPGILRLCGPYDTSVGAHNAHPGCDLWLSPSGSIARLVATHSDSQNASPGHTVANPPNTSNLEEWKALVIEWLGNYGLPLNSSEDEPWVEVEVWEPFYSRLAGEVWRQNEEGASVLPLKRILWPARYCFTRKKPTSLDPFLGINDTFPVIDEPLGFAEKWLGMGQLNHETDSKPASRPEAETKDQETPLSRPDLPEGIESLSRAAEYPDLQASNLVYPTPPDGAFPVGPNPPPASDAAAEDLDSRHLTNRALVNVKSKEETSARDRSDHDVLMSFGPSPGLIVGSGLYDTNDDDDDDLFGEINQRDFGSKGITDADFSFFDDPEFNHLGGDVSEMDVGAQETPEIAVDAEEPKAHPLSLEQPLTNDNLPGRRDTTEQVDTVLAHPEEKISNLQPADVPLSANMQISSPVNEDNQTISPPLSPIEVKKTLFAGPNEDSKLSVQKGHLQGHYNPVAFKANILDWDQKYGAEGKFRVSGAVVNHHTVPASTTGDIPTIGLPRRNARTKNPYVPARNNDKPKSPASDVDQPLPSDSDFDSTSDTSDDSDGNLSNSDESVATFVTRKRKRARSYSGSSVNLPQQKPLARSEQSIATSRTDDLVFLGNFLSTFSDWSMTGYFSAIQKQLAPVLIRKDAQIEVAQLLVEQVTQSCLDHKVDGILNVSEFESKTYSLRTFLEDTAFMGEIERLDLNGFVSLQENSGLSPPLTATMSRQSSQRKENGKSSILKLAPPHLRIRRGKDYLEVLPPAISFWETFGLEPAYGSKDIYAYCIHPQTAAEAANDFLERLGLLYSSCNLGQHTRASRSTGFDRGMCSWNIGAPGEFNYHYIMQSLKSICDKLVTALLKSPPTRDSVVVYIINPFSHAAALADICSAFYDLFQKYIDEVENQQAGQASELVLQIVPFHFIMSTESLVVPPQAQYLSLALEVYSRCPPKSLQSCLLNCAPPMLIAEPVPKTINFKLAPDSSSPLQEAKSLHIACSRSYDQRWVSVSWTDNTGTFQRTLSYCLRFQNSNATRNILEVRTEIWAATKMIMEKTQARWKIIIANTEPVDQDEVDTWTSLVEQYNTTKPFPSDLTILYVNTTPDLYLEPPPQPLSMSVFNPQISSTPVATPNPSGNAFSPEQPGNAPTPPSGGNAPTPTEIPPDAESECLLTDICDESWGIILSHCLNSSPHLTDYRPALASGYLLRRKGPTDADGAFAMNVNLIYSQKPASLYENLLREIIARYRDLATLARARGTRTVQQNTFPWHIATALRAQELLSYVL
The following text describes a protein:
Function:
Required for normal Golgi morphology and function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Sequence:
LNGNGGTSEKSRVSKFSLHPPSASIPSKSDPVAAAAAAAARINANLRAKGKLSDQTQHKPVVNTIQTANSALSAIQVSQIKKIFDLYVAKIDINNLPIVTRTYMTQVNAQEIINKQTGAAVSTKGQYLTQDEKKNVEGIDKQLHLYVQSPSQDKVELAINKIKDMISKHNVSKSSLSAVAPTMVPPMVSMPIPQNMVGQPSLPSGNYVHDKLFIGMDYVPPDFDLKTKLIGANYTNFNFVANSTGAKVILRGRGSGFIEPTSGREAFESMYVFISHPNQAGVDAAKKLVNNLIEHVRNEYNAHTRKTQSGFGNPQAAYPGNPPYGSNSVNYQPPSQFPSYPMAHPNIPPPVPVPPPTFTPPTQPPFNPQATPNITPTPQAAPTSDMMPPPPPVAVKPTEPAPKPTKRRRFKEEQPDDSNILGYQ
The following text describes a protein:
Function:
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Miscellaneous:
MISCELLANEOUS: A synthetic peptide, NIPP-1(191-200), is able to inhibit PP-1. Alanine substitution of Val-201 and Phe-203 in NIPP-1(191-210) prevents PP-1 binding (far-western assay) but do not affect PP-1 inhibition. Phosphorylation of Ser-199 or Ser-204 prevents PP-1 binding (far-western assay) and reduces PP-1 inhibition.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Mainly, but not exclusively, nuclear.
Domain:
Has a basic N- and C-terminal and an acidic central domain; The FHA domain mediates interactions with threonine-phosphorylated MELK.
Sequence:
MAAAANSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEGPGSLVLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIHGTALIGGLPMPYPNLAPDVDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAYFLVRNVLILAFLLLIPPFMGEFWAYQLGLYFIYGLAALGVGLAWGQAGILPLGQGMFVAIAAYVTAHGLLALGSSPIAYLALPAACVLVAVLAFAFAALVFRGRFEQGPSFSLMTLALTLAAFQVANGWSSVTGGFNGLRNIPGLPGLDGFLDLYYLIAILLGLSIAAVDYLVHAPIGVLWRAAADNERRLAFLGYDVAVIKAVAFAVASGLAGLAGALYAPQQNLVTPDLAGFAFSGDLVIFAAVGGRATVLGPVIGAVVVGVLSAELRDRFPWWEIGIALFFIVVVLRLPGGLMTMLAPLRRFSSARTSVRARSTAPEKPRISTSLSVAFEDVRVRVGDVTILDGLSVRTGEEAVLCVIGPNGAGKTSTLNVMTGMLPRRGGRIVIDGAVVLRPEPAIVANKGVARKFQTPSVFPKLTIDENLAVALWAGRWCGFDLLRLGLFGWTSPLLEEMRGRFQFLNDGTRPASALSHGERQILELTMALITEPRMLLLDEPCAGLSHEETAAVIDAIQWARGELNLRIIIIEHDMELVRRLANRVVVLHQGRFLADGSVEEVQRNPEVRAVYVGGSR
The following text describes a protein:
Function:
Probable palmitoyltransferase which is required for photoreceptor synaptic transmission and for the correct expression and localization of palmitoylated protein Csp and synaptosomal-associated protein Snap25. Probably palmitoylates Csp. Probably also palmitoylates the dorsal-ventral patterning protein Sog and promotes its secretion and activity and the stabilization of the membrane-bound form. Required for synaptic vesicle exocytosis.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein. Note=Localizes to the Golgi apparatus in non-neuronal cells and located primarily in presynaptic terminals in neurons.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MYQSACQAATTGSCVPGTGQQPDNERQSALIAQQPPTAPVEPDYSGFDIVKATQYGAIARVRELVESGWDVNQPDSETVTLLHWAAINNRRDIIRYFLEKGATVDAVGGELNATPLHWATRQGHLGAVVLLMAAGADPRIRDAEGCSCIHIAAQFAHTALVAYFIAKGVDPDLQDRGGMTALMWAAWKVCALDPVRLLLTLGANPAMVDYTHGNTALHWAILARNATAISTLVLKSKASLDVPNLRGETPLSMLESQTGAIWIGAKVMDRVKEAALTSQQRRSLLSKLRHDKRLRWWSMVACPFTAFYLAGIVFTVNTLYIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVTWLMYIDDAVSFTATVCFLISSLLLWVCFLKSWKGDPGIIRPTREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRFDDFLGAMRAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNERMNRGRYRHFQAKGGHSPFTRGPIQNLVDFLECSCFGLVQPKRVDWMNYYDYDAQTHQTIEKEPLLSVDCPDGMAGDHQYV
The following text describes a protein:
Function:
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAPEIQWIRDDASLAQQCREWRTQPYLALDTEFMRVDTFYPAAGLVQVGDGRQEWLIDPLLIQDWSPFAELLEDERVVKVLHACSEDLEVFLRLTGSLPVPLFDTQLAAAYLGMAHSMGYSKLVKEVLDIDLPKDETRSDWLQRPLTEMQMRYAADDVQHLAQVYLALDTRLSEEKRAWLLEDGAELVANLCRESDPREAYREVKLGWRLRPQQLAVLRELCAWREEQARLRNRPRNHVLRERTLWPLARLLPKNKTDLAAIEDMHPRTVRQDGDFLIELIAQAARLPQSEWPEALPEPLPPEVTPLLKSLRAIGQREAETLGMAPELMLRKKVLEALLKSGYPDGPYELPDSLRGWRRERMGQALLDALESA
The following text describes a protein:
Function:
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Subcellular Localization:
Cytoplasm.
Domain:
Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
Sequence:
MSIKEPIRVLLVEDSPSQLQLLRSYLEATPDLVVVGTAINGRDAVQSTLRLHPHVVAMDIHLPVFDGYEATRQIMQQRPTPIVLFSSSTGDAEQRAMAALAAGALAVVRKPSGPVDPASAADRDHLIRTLRLMAGVKVVTRHPPRMTPKQIDQANKEYAILAIAASTGGPAALQTILRDLGSSFPLPIVIAQHVTSGFMRAFADWLASTIPLSVHVVEQETPILPGHVYLPCDDHHLEIVRQHVVTIKRSTPHDRYCPSADHLFSSVAHHYGSRAIGVILTGMGDDGAQGLLELARAGGTTFGQDEASCVVYGMPKMAKVRGAVHHELPLEQLGMAVSAVLGKGGRG
The following text describes a protein:
Function:
Essential for the assembly of the mitochondrial F1-F0 complex.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRSLQFYRLSSKNLLSFKTCYSFYSTKASSPLPQPSFRRFWKNTATKIQNGEVLIQLDGRNLKSPSGKIVKVPKEMELLAHLIALEWDRLPSTSVRQHNLPITSLVSRAIDISQFKKEEKELLSTQLIRFLDTDTILIYSPETEYEGKLLEEQKENWWPLKETFENKLGVQLSYLDGDAGIIAHKQTQETHERIRNWLSSLNSWQLAAFERSVSCCKSFIVSFMILKGYLNSEKAAALTNLELQYQTNRWGSLEDAHEIDNEDLKNKLASSAILSRCIEDMHDKSNEHAH
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSDSELCRKWARCMADAVVKIGTGFGLGLVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYDKGQEQ
The following text describes a protein:
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC; Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis; Isoform C is proteolytically inactive.
Miscellaneous:
MISCELLANEOUS: [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Sequence:
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS
The following text describes a protein:
Function:
This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Sequence:
MAPIALTSSATSPPGLPAKKAALAAADVDAGLNLDADGASTPYSATSTAVSVGENNKDSKPASPSALAKALVDSSIPSSVPLPTDDGYYTNLIASSLPVAATKPGTAVFASAIDGLEALAVKHSESVWVYDDAELVGFGSRLGGLGKKKVHELQTREGAGLELAGYASKTQGKFTVFASIKTLQYLLPSLEAIEGDVIINLATTSTTDDLEFADALYAPGTVKALTSLPEGWEVVFSSGERIVDNASKLYGAEPKKVVHVVESTFTGRETTSFTFPAPQSAAIDDLTVHNGSASELYVAPAGYLASSIAAALPASAGLVELNTLSPSPEALYAALTSNDRKTVHVVGASKVDAEALKAIVLASVYAASGSSKVALPLVKSLVATSVESISALAQSTTATPGKVVSFYTAPASPLPQLLAHLFLSSPSLSTHIAQFGSASARGVKSVLSLAPAGTSRAALSVEEPTDVTWISDPNVLKSADVFSVAKEGSIVVLALPWSEEEIPVKFTRSEIQTIKSKNLRIFSLYLSSSPTTPIQEQVAFLLLYTGAQKLAPGVWKVLDAFHNHQLVRDDVEIAQAALNEIDAKEWEVPELEEGKTEKVKSKWEWDALPGLAGVVAANDEQNSSVGPWELAARHLFFREAFAVPEATTTDASQGLPGINALRPSMSEETFLVTVSENRRLTPATYDRNVFHLELDTAGTGLKYEIGEAIGIHGWNDTKEVREFCEWYGLDPDAVVTFPSPTRQGTLETRTVFQLLQQNIDLFGRPGKAFYAALSKIATTKAEAMRLKFISAPEGAELFKRLAEDITVTFADVLKMFKSARPGIEELVGLIPEIKPRHYSIASSQKAVGDKVELLIVTVDWINSKGSPRFGQCTRYLAALKPGDKVTVSIKPSVMKLPPDNKQPIIMAGLGTGAAPFRAFMQHRAWQRSQGIEVGPLIYYFGSRYRSQEYLYGEDIEAYIASGIISHAGLAFSRDSDSKTYIQHKMSQDKSMLARLLKGKGSDAAYFYLCGPTWPVPDVYEALVGSLTREGGMERKEAEEYLEELKEEERYVLEVY
The following text describes a protein:
Function:
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Sequence:
MKKHLHHKVSGSCDPGDRSPKEKGRSQGIRNLLILISLSIIPYLSCLGGDFVFDDAESIVNNPIVNGKDPLLQIFSRDFWGRSISSSNSHKSYRPVTTFTFWLNYKLHETSTLGYHVVNIICHTVATLVFYKLGKQLEHIFDFFNIAFSASILFAVHPVHTEAVANITGRAELLMTIFSLAALILHVKNREINCKFVLLVILSTLSKEQGLMTIPIAICIDFLAHRSCRSNFVRMICLLVAIGFLRMMVNGFEAAKFTKLDNPTAFLNSKFYRMINYTYIWLYHAYLLVIPVNLCFDYSMGCISSITTMWDLRALSPVLIFTIVIIGVKFQNECRAFTLSSLMGIISFLPASNIFFTVGFSIAERVLYLPSAGFCLLCAIIFKKLSVHFKNADVLSITLILLLISKTYRRSGEWKTELSLYSSGLSVCPTNAKIHYNLGKVLGDNGLTKDAEKNYWNAIKLDPSYEQALNNLGNLLEKSGDSKTAESLLARAVTLRPSFAVAWMNLGISQMNLKKYYEAEKSLKNSLLIRPNSAHCLFNLGVLYQRTNRDEMAMSAWKNATRIDPSHSQSWTNLFVVLDHLSQCSQVIDLSYQALSSVPNESRVHMQIGSCHAKHSNFTAAENHIKSAIDLNPTSVLFHANLGILYQRMSRHKEAESQYRIVLALDSKNIVAKQNLQKLEEHNCYNSTLP
The following text describes a protein:
Function:
Catalyzes the attachment of glycine to tRNA(Gly).
Subcellular Localization:
Cytoplasm.
Sequence:
MGERFDKYEYLQDLMRRRGFAWGSFEIYGGSRGFYDYGPLGATIKRKIEKKIREAFIREGFFEIETPDITPEQVFIASGHVEKFVDPIVECKKCGARFRADHLIEETLGIDVEGKSAEEMTKIIREHNIKCPECGGELGDVFYFNLMFETYIGPYKDKKAYLRPETAQGIFVNFKRLNAFARNKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEVEIFFNPNETEHPHFDEVKHEKLRLYPIENQLKDLGMIELTAEEAVKKGYLMNTFFAYYLVMIKKILLDIGIPEDKIRFRQQLPEERAHYSADTWDAEVYSERFGWVECVGLAYRTDYDLSRHMKMSGADLTVMIHYDKPKIVKRLKVSLNMKSVGPKLKKDAKRINEKIQAMSEEELRELVKKLNEEGKIVIDGYELSKDDFIIKEVEEKVTGEKIIPHVLEPSFGIDRPFYLLLENSLTIDEDGRIYLKIKKDMAPIEVAVLPLVAKEPLTKIAYDLFRKLQKEGFIVVYDEKDSIGKRYMRYDEIGTPYCVTIDNQTPIDGTVTIRDRDTREQIRVKLEDVPRKLKELIFGS
The following text describes a protein:
Function:
May play a role in a redox process.
Sequence:
MNIAIVTINQENAAIASWLAAQDFSGCTLAHWQIEPQPVVAEQVLDALVEQWQRTPADVVLFPPGTFGDELSTRLAWRLHGASICQVTSLDIPTVSVRKSHWGNALTATLQTEKRPLCLSLARQAGAAKNATLPSGMQQLNIVPGALPDWLVSTEDLKNVTRDPLAEARRVLVVGQGGEADNQEIAMLAEKLGAEVGYSRARVMNGGVDAEKVIGISGHLLAPEVCIVVGASGAAALMAGVRNSKFVVAINHDASAAVFSQADVGVVDDWKVVLEALVTNIHADCQ
The following text describes a protein:
Function:
Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death. Involved in protection of the genome against mutations.
Subcellular Localization:
Nucleus.
Sequence:
MIHSNEPLPYAIEYAKSGRSNCKTCKKNIALDQLRMSMNRPSTFFDGNMDSWFHYNCFWIKMIRGRDDINISSIRGVDWLRWEDQEKLRQEIQHFKTASPPTLTPLCSTTTVILSTIKTEKSLSNRGKCGKCGQNFERGEIKAHNKGKANHFKCFLQEFDKISGTVEDIPGWADYEENFKIKAVGEYVEALAAKRRSTEPATPASASPTPPEAETPVLSAEGSPESSNKRPASSEIIEIDGEGNPDENDFAKKRRMKKEARLMEVQKKRMKKQSDLLWEYRQIFERMPYTDKISILRENEQDIPEGHDPTAQVIERLVDNALFGCPIICQTCSNGKIVYNSSCRTYVCTGYATEYSKCTYESKNPIRTPFEVSHRLTEKHKLQDIVFNQMSERLYIGEEDGESVVKIDKRKSKGGTRGEQFIYAAEAFDSTNNVPIKVGDLTSTNTHIIKKGTVVDAKFALADRCHVFKNEIDGSLYQATLSFTDLTQNKNSYYKIQLLKDDQRENYYVFRSWGRVGTEVGGNKHESYSNSNEAILKFQDVFHEKTKNDWIYRKHFRKMPGMFSYVETDYSEFAQITDTEITPGSKTLLPKSVKEVVMSIFDVENMKSALKSFEMDVNKMPLGRLSHNQINLAFEVLNDISDLLVKLPIDASRILDFSNKFYTIIPHNFGMRVPEPIDSFHKIKEKNNMLNALLDIKFAYDQISGGDVPASTSLGIDPVDINYQKLKCIMEPLQQGCDDWNMIHQYLKNTHGATHDLKVELIDILKLNRDNESSKFKRHIGNRRLLWHGSGKMNFAGILGQGLRIAPPEAPVSGYMFGKGVYFADMFSKSFFYCRANAKEEAYLLLCDVALGNVQQLMASKNVSRQTLPAGFQSVQGLGRQCPREIGSYNHPDGYTIPLGLTYMQLQGKQDVDYHLLYNEFIVYDVDQIQLKYLVRVKMHHARHL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that functions as a regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way. Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering. May function downstream of HAL3 and be required for HAL3-regulated plant growth. Activation of MBR2 by HAL3 may lead to the degradation of cell cycle suppressors, resulting in enhancement of cell division and plant growth.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MQGPRSTGDSSTGINYADGEPICSTNSETTSNNILNPVDVQFPNNTTGSGRPTYASSSSHVVQNHNWWSFGESSSRLGPSDHLNSNGSKTDRQLLSDGYGFEEGQSGMLLPGESFLRGSSSSHMLSHVNLGKDMDIGSGLQTSGVVIRHNNCETSLGSSSQTAEERSSGPGSSLGGLGSSCKRKALEGAPSHSFPGESHGCFFQTENGAWNEGLAQYDASSSLSLSMPSQNSPNVNNQSGLPEPRFGLGGGRAVTASAFPSTRSTETISRPGRRLNPGQPPESVAFSFTQSGSSVRQQQQLPATSPFVDPLDARAIPVTGSSSSGDGQPSMIHLPALTRNIHQFAWSASSSSRANSMPEEGLSPWDAPRINSEQPVFTTPANETRNPVQDQFCWSFTRGNPSTSGDSPFVPRAGSSSGIHGLQPNPTWVTPHNQSRISEVAPWSLFPSIESESATHGASLPLLPTGPSVSSNEAAAPSGSSSRSHRSRQRRSGLLLERQNDHLHLRHLGRSLAADNDGRNRLISEIRQVLSAMRRGENLRFEDYMVFDPLIYQGMAEMHDRHRDMRLDVDNMSYEELLALGERIGDVSTGLSEEVILKVMKQHKHTSSAAGSHQDMEPCCVCQEEYAEGDDLGTLGCGHEFHTACVKQWLMLKNLCPICKTVALST
The following text describes a protein:
Function:
Secreted effector that hijacks host cell SUMOylation during A.phagocytophilum infection and is important for the pathogen's intracellular survival.
Miscellaneous:
MISCELLANEOUS: Pharmacologically inhibiting sumoylation in infected cells significantly reduces the bacterial load.
Subcellular Localization:
Secreted. Host membrane; Multi-pass membrane protein. Host cytoplasm, host cytosol. Note=Localizes to the A.phagocytophilum-occupied vacuolar membrane (AVM). Potentially traverses the AVM 3 or fewer times by means of the 3 bilobed hydrophobic alpha-helical domains that are predicted to be in each direct repeat. Colocalizes with SUMO2/3 on the AVM and in the host cytosol throughout the infection cycle. Only late during the infection cycle AmpA colocalizes with SUMO1, which terminally caps poly-SUMO2/3 chains. Is probably not secreted via the type IV secretion system (T4SS).
Sequence:
MYGIDIELSDYRIGSETISSGDDGYYEGCACDKDASTNAYSYDKCRVVRGTWRPSELVLYVGDEHVACRDVASGMHHGNLPGKVYFIEAEAGRAATAEGGVYTTVVEALSLVQEEEGTGMYLINAPEKAVVRFFKIEKSAAEEPQTVDPSVVESATGSGVDTQEEQEIDQEAPAIEEVETEEQEVILEEGTLIDLEQPVAQVPVVAEAELPGVEAAEAIVPSLEENKLQEVVVAPEAQQLESAPEVSAPAQPESTVLGVAEGDLKSEVSVEANADVAQKEVISGQQEQEIAEALEGTEAPVEVKEETEVLLKEDTLIDLEQPVAQVPVVAEAELPGVEAAEAIVPSLEENKLQEVVVAPEAQQLESAPEVSAPAQPESTVLGVTEGDLKSEVSVEADAGMQQEAGISDQETQATEEVEKVEVSVETKTEEPEVILEEGTLIDLEQPVAQVPVVAEAELPGVEAAEAIVPSLEENKLQEVVVAPEAQQLESAPEVSAPVQPESTVLGVTEGDLKSEVSVEADAGMQQEAGISDQETQATEEVEKVEVSVEADAGMQQELVDVPTALPLKDPDDEDVLSY