lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MFLNGSFRRFAACSVRVGRFGCSQGACPMFNEYHSKAVDMEQPYYGKKKELLQNALHHVPELGFTNEALARGAQDSGYTSLPAVLFPRGGLDLFDFFHYVQRKALHELKPHLSTIPSMKERIIELLWARLYANRDVNRHLPSILALSSRPLNIRHSLKTLGLLANEILFLAQDSSNDFQWYTKRAAVASIYGLSELYMTRDTSPDFGDTYRFVSHRMDHAASLNSIRREIGSWLTFQSRAVSNIMRSKGF
The following text describes a protein:
Function:
Acts as a regulator of cell proliferation and elongation in the root and shoot. Regulates roots architecture and primary root protophloem differentiation. BRX, BAM3, and CLE45 act together to regulate the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem. Probable transcription regulator. Regulated by the auxin response factor ARF5. Polarly localized in vascular cells and subject to endocytic recycling. Required for CPD expression and for correct nuclear auxin response. Mediates cross-talk between the auxin and brassinosteroid pathways. BRX is a target for auxin-induced, proteasome-mediated degradation.
Miscellaneous:
MISCELLANEOUS: The truncated variant in cv. Uk-1 results in short root phenotype.
Subcellular Localization:
Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=The translocation to the nucleus depends on the auxin concentration. Polar localization at the plasma membrane, rootward oriented, in developing root protophloem cells.
Domain:
The DZC domain is necessary and sufficient for dimerization. A C-terminal fragment containing both DZC domains is able to rescue the short root phenotype. The N-terminal part (1-57) promotes BRX membrane association and is required for efficient degradation in the nucleus.
Sequence:
MFSCIACTKADGGEEVEHGARGGTTPNTKEAVKSLTIQIKDMALKFSGAYKQCKPCTGSSSSPLKKGHRSFPDYDNASEGVPYPFMGGSAGSTPAWDFTNSSHHPAGRLESKFTSIYGNDRESISAQSCDVVLDDDGPKEWMAQVEPGVHITFASLPTGGNDLKRIRFSREMFDKWQAQRWWGENYDKIVELYNVQRFNRQALQTPARSDDQSQRDSTYSKMDSARESKDWTPRHNFRPPGSVPHHFYGGSSNYGPGSYHGGPPMDAARTTTSSRDDPPSMSNASEMQAEWIEEDEPGVYITIRQLSDGTRELRRVRFSRERFGEVHAKTWWEQNRERIQTQYL
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MVFAHLYVLNVLGLLLFVHLSAGDAGSGPPASAAAPPPPPPPPARALPRLEGIKVGHTQRVELGPGRTRAARTLSLKPLLFEIPDFLTEEECKLIIHLAQLKGLQKSQILPTDDYEEAMEMIEISQMDFFNLLDHNQDGQLQLKEVLTHTRLGNGRWMTPENIREMYTAVKADPDGNGVLSLEEFKRLNIRDFHKYIGSQKVKMSDAVRNSQHTWLYQGEGAHQVMRAIRQRVMRLTRLPPEIVEHSEPLQVVRYDQGGHYHAHMDSGPVFPETACSHTKLVANESAPFETSCRYVTVLFYLNNVTGGGETVFPIADNRTYEEMSLIQNDVDLRDTRKNCDKGNLRVKPQQGTAVFWYNYLSDGEGWVGELDDFALHGGCLVTQGTKWIANNWINVDPNRRRQQRFQQEMERYAGSGAGAPGEWTVDKAYSGVHVEL
The following text describes a protein:
Function:
Plays an important role in the degradation of dermatan and keratan sulfates.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEDDNVVISLKQTLEWTDYFGFVAVWVIFFVTIAAVSFFCLNWCCVQKEDDITVFEKWAAPRKMKLGVHRLSVVGRKMDEEKKMENEAREVRQLNDLWSFVREPCNSIGYGFLHEWFRQDISRFHNATVMPVPSAFNDLEDLSLRDHVGWVWYQRSEFIPARMSKGRTYIRLDSVNYYAKVLDITQFIVFGQKNRITVAINNTLSHHTLPQGDVKATGYQDHIYQRGFMDFFSYSGLLRPVRLLFLPKTHISSQSITADAKGILTFAHSVIGTGYSKVEVTVTDAEGEVEYTSDSFNGTGKISKPHLWWPRNMGKPYLYTLTVRLLSNSSLVDVIRTQFGFRSVSWDHSQILWNGKHFHCQGFGMHEEYEVRGRAFDSVLMTRDLNLVEWTGANCYRTGHYPYSEERMAENDRRGIAVIVETAAEIQNLHMDYIRSTIDRDRNHPSIFMWSLANEPSASIKEANPYFAPLVKLAKSLDPTRPITVVLASSPSSDYVGGLLDVICFNRYYGWYSNIGQLYRIEHDIYNEISMWNKKFSRPIIISEYGAEAIPGMHKDPPFAFTEEYQVEVLKEHHKAFDRLKKEKKLAGEMVWVFADFMTVQDTTRVVGNHKGLFTRQREPKMSAHLIRKRYSSNTSRHRDEFLQKRLNVIRLHFIQIARLPSFSISLLRHHSLVIRRSQPVAPYSSLPLSDPLPLNTPPCSTIPLLPVLLPSSSPPITSSFLLHYPDRPTPSNSRSDPLSGLSASHWYHGLLPRDDIKTFLVENGDYLVRMSEPVEPGKREYILSTMFDKSIGKIKHFVIVHSGERFILHSKSFRSIPELVKYFASTKKSLTGQMEVVIRRAIARSEWQLEHEEVQSTKKLGEGAFGEVHKGILKLRRCNKKIDVAIKLAKLDAMTKDQIQGFMKEARLMRDFDHPNVVRLYGVAATQEPLMLVMELASDGALDSYLKKHACTVQTKLTMILQAAWGIEYLHERPIIHRDLASRNCLYGDGKVKISDFGLSREGRAYVMHKKCRLPVRWLAPETLRQLQYSTKTDVWSYGRQRTIYNWLDYRISGIMCWEILNDGKEPYPGMTVAEVNVKVREGYRMPIDFLPGLDGDVINLISHRCWSEDKESRPEITVVARELERVTHTPRPESRDAIFGRSPKVAKTQQITVKMPHMPMPPSSE
The following text describes a protein:
Function:
Starch granule-associated phosphoglucan phosphatase involved in the control of starch accumulation. Participates in the regulation of the initial steps of starch degradation at the granule surface. May release a different set of phosphate groups from those removed by DSP4.
Subcellular Localization:
Plastid, chloroplast. Note=Located on the surface of starch granules.
Sequence:
MAFLQQISGLGALERSCPSIMIGSSFRSGNGRVFDGRGIAYLGSREKFGFNRRRRVVLRVVAMSSSSTPFKMNLNEYMVTLEKPLGIRFALSADGKIFVHAIKKGSNAEKARIIMVGDTLKKASDSSGGTLVEIKDFGDTKKMLVEKTGSFSLVLERPFSPFPIQYLLHLSDLDLLYNRGRVSFVTWNKNLLSSNLRASSQGSGNSGYAAFSSKFFTPQGWKLLNRQSNSFQSGTKKNILSPPISPLVSVFSEDVPGDGEWGYGNFPLEEYIKALDRSKGELSYNHALGMRYSKITEQIYVGSCIQTEEDVENLSEAGITAILNFQGGTEAQNWGIDSQSINDACQKSEVLMINYPIKDADSFDLRKKLPLCVGLLLRLLKKNHRVFVTCTTGFDRSSACVIAYLHWMTDTSLHAAYSFVTGLHACKPDRPAIAWATWDLIAMVDDGKHDGTPTHSVTFVWNGHEGEEVLLVGDFTGNWKEPIKATHKGGPRFETEVRLTQGKYYYKYIINGDWRHSATSPTERDDRGNTNNIIVVGDVANVRPTIQQPRKDANIIKVIERVLTESERFRLAKAARCIAFSVCPIRLCPKS
The following text describes a protein:
Function:
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Bacterial flagellum basal body.
Sequence:
MAGNEQMDQDAIAAQWEASLDSEDPAEAAKAAAENELSETMALQWAAMVEDGSRDLGSGKNSGERVLSQEEIDNLLGFTVGDVTLDDHSGIRAIIDSAMVSYERLPMLEIVFDRLVRLLTTSLRNFTSDNVEVSLDRITSVRFGDYMNSIPLPAVLSVFKAEEWDNFGMATVDSNLIYSMIDVLLGGRRGTSQLRIEGRPYTTIETELVKRLVEVVLADAEQAFRPLSPVTFTIDRLETNPRFAAISRPANAAILVRLRIDMEDRGGNIELLLPYATIEPIRGVLLQMFMGEKFGRDPVWEGHFATEIGQAEISVDAVLYEADIPLKQLMRLKVGDTLPLDMRADANVTVRCGDVTITEGRMGRVGDRVAIRVTKPLRKPSTTLAMFEKVDEQNKMMEAP
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MTMIMDFEEATGNAGTPDIEVSVIKDQGICPHVDKGIDLAKLSAKLRRSESFNCECSDSNSGYKSIWICLECGCFSCGDFVIPVTPGSHAVLHAKRSGHPLVVHYRNHKKLVWCFPCNKLITSDRDNKTRKVLNKVVRIMRGMSVEGLSFNVEDVWFGSGSATNDVKSESCLGCSVRGLVNLGNTCFFNSVVQNLLAIKSLREYLFGLNGYYLGPLTYALRNLFFETSGEEASLTSAMNPGYLFFSLCTRAPEFNGYGQHDSHELLRCLLDGLSAEELRRRDVVKFPSVGPTFVDAIFGGKISSTVSCLECGHSSTIHEPFLDLSLPVPTKKPLAKQVPPFSVSDQSSGDRWTVPQAPEQFADPDTMPKKQQEPVESFEDKSHETNVSLTDAEISAIRGFANIDIPQNLVSPSSTLKCTTESDSVNTVSASPSDNSKHLNNSIEDSNTSQIQDSKKDEIMEEQDSLNFDGFGGLFDEPSESIDTRVSTESDPEEIDPTASVESCLECFTKAEILAKEEHAWQCDNCSKVLQEQRNRLKRTLSMSELEETTTGGASVKSEDLKVKRDARKRVVISNAPSILTVQLNRFRQDHGGQFSKLNGHVHFGETMDLKPYMNPRCDEGAKLEYRLVGVVEHIGSMRDGHYVAYVRSSEDCVWYHANDAYVCEASLEHVLSCQAYILFYERA
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDRRAYCQAQNNALEMNSSTKYKRYGITPHRKECCLRVELALNYEYIEEDLSNKSPLLLQLNTTHKSVPVLVHNGKAIAESLIILEYIHETWTKNAPLLPENAYKEALVTETFRAIVWNSGKEQDMAVLAFTENLKLFENGVRKEFERENPFFNEESPGLLGFLVGSLSCWIKLLEEIFEERLVETEKTPHFCSWLCALNKVGVVKESSFEHGKLLAYAKALREKIFGTPNMGPND
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MASAAADDDLDLAFRLQLAEALQASLRLDTRNPSSSKTPAIASSSTSSSSSRPGPLDSDAAYALALHAADLRRAEEDHRYAKACRAYHARAAASVRVAAHDAVFARELAAVPEDRWADDGDNIERPLESSAAAGPLFRVFFKGMSSKEVVAPRDRDPGVAALAVAICGPQGEVVLRVQKPVQAFVGGRMTLEVMALNEGLHAALGLGIQSVKIVTDYRSLSNHLLGYWHPTQKKVIDVLNQAASLRKKFQRCQISLVQRNQLDYVMKLARDSIDSQVAKAAAMDASKEKRETCTICLEDTDVTKIHAVEGCGHRFCFSCMKEHVKVKLLDGTLPACPQDGCTTKLSVEGSKIFLSPRLLDIMVQRIREAQIPPTQKIYCPYPKCSALMSLSEVIRPMQESSSKYTIADAATLRNCVKCRGSFCISCKVPWHDRMSCYDYKRRYPHARPEDAKLQNLARQQLWRQCIKCKHMIELAEGCYHMTCVCGYEFCYTCGKEWKEKKATCSCPLWDEGNIIHDDSDEDDDDDDDDYDEDEDDDDDYYPANQDHGRHHGGGGAQVHYGYNNNPGRHRRGGAPRIFYNYNN
The following text describes a protein:
Function:
Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
Subcellular Localization:
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Sequence:
MGQEDGNRGERRAAGTPVEVTALYATDGCVITSSIALLTNSLLGAEPVYIFSYDAYTHDGRADGPTEQDRFEESRALYQASGGLNGDSFRVTFCLLGTEVGGTHQARGRTRPMFVCRFERADDVAALQDALAHGTPLQPDHIAATLDAEATFALHANMILALTVAINNASPRTGRDAAAAQYDQGASLRSLVGRTSLGQRGLTTLYVHHEVRVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLTTRYYLLQAQRLGGAGATYDLQAIKDICATYAIPHAPRPDTVSAASLTSFAAITRFCCTSQYARGAAAAGFPLYVERRIAADVRETSALEKFITHDRSCLRVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPNPAASTEQPSPLGREAVEQFFCHVRAQLNIGEYVKHNVTPRETVLDGDTAKAYLRARTYAPGALTPAPAYCGAVDSATKMMGRLADAEKLLVPRGWPAFAPASPGEDTAGGTPPPQTCGIVKRLLRLAATEQQGPTPPAIAALIRNAAVQTPLPVYRISMVPTGQAFAALAWDDWARITRDARLAEAVVSAEAAAHPDHGALGRRLTDRIRAQGPVMPPGGLDAGGQMYVNRNEIFNGALAITNIILDLDIALKEPVPFRRLHEALGHFRRGALAAVQLLFPAARVDPDAYPCYFFKSACRPGPASVGSGSGLGNDDDGDWFPCYDDAGDEEWAEDPGAMDTSHDPPDDEVAYFDLCHEVGPTAEPRETDSPVCSCTDKIGLRVCMPVPAPYVVHGSLTMRGVARVIQQAVLLDRDFVEAIGSYVKNFLLIDTGVYAHGHSLRLPYFAKIAPDGPACGRLLPVFVIPPACKDVPAFVAAHADPRRFHFHAPPTYLASPREIRVLHSLGGDYVSFFERKASRNALEHFGRRETLTEVLGRYNVQPDAGGTVEGFASELLGRIVACIETHFPEHAGEYQAVSVRRAVSKDDWVLLQLVPVRGTLQQSLSCLRFKHGRASRATARTFVALSVGANNRLCVSLCQQCFAAKCDSNRLHTLFTIDAGTPCSPSVPCSTSQPSS
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MGGHHYNPEAEPKKDQNLQAIKDARTPLAWRDTCSHILVDLNKCRRETWWNPNKCEHARHVYEECEYNAYLQRIEAKVQLDKLNAQE
The following text describes a protein:
Function:
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine. Particularly important for the repair of UV-induced pyrimidine dimers. Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis. Targets POLI to replication foci.
Subcellular Localization:
Nucleus. Note=Binding to ubiquitinated PCNA mediates colocalization to replication foci during DNA replication and persists at sites of stalled replication forks following UV irradiation. After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%; this recruitment may not be not restricted to cells active in DNA replication. Colocalizes with TRAIP to nuclear foci.
Domain:
The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity; The UBZ3-type zinc finger domain and the PIP-box mediate the interaction with ubiquitinated PCNA and are both necessary for the enzymatic activity in translesion synthesis.
Sequence:
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPFQTSQSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLEESSKATPAEMDLAHNSQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQKSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFFKPLTH
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (Probable).
Sequence:
MDLTLIIDNYDSFVYNIAQIVGELGSYPIVIRNDEISIKGIERIDPDRIIISPGPGTPEKREDIGVSLDVIKYLGKRTPILGVCLGHQAIGYAFGAKIRRARKVFHGKISNIILVNNSPLSLYYGIAKEFKATRYHSLVVDEVHRPLIVDAISAEDNEIMAIHHEEYPIYGVQFHPESVGTSLGYKILYNFLNRV
The following text describes a protein:
Function:
Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.
Subcellular Localization:
Nucleus.
Sequence:
MSSAAVSKYVNDMWPGSPQEKASPSTSGSGRSSRLSSRSRSRSSSRSSRPHSRSSSRSSSRSHSRPRRSRRSRSRSRSRRRHQRKYRRYSRSYSRSRSRSRGHRYYRDSRYEQPRRYYQSPSPYRSRSRSRSRGRSHHRRSYYAITRGRRYYGFGRTVYPEDRPRWRERSRTRSRSRSRTPFRLSEKDRMELLEIAKANAAKALGTANFDLPASLRAKEASQGAVSCSGPKTEHSEKQTEVGTKNASEKSAAAQRNIAFSSNNSVAKPLEKTTKAAVEETSSGSPKIDKKKSPYGLWIPV
The following text describes a protein:
Function:
Possesses endo-beta-mannanase and mannan transglycosylase activities. May be involved in cell wall degradation during fruit ripening.
Subcellular Localization:
Secreted.
Sequence:
MNNSIILIFVAILIIFPNEFSKPTRAFSNNNFVYTDGTHFALNGKSLYINGFNAYWLMYIAYDPSTRIKVTNTFQQASKYKMNVARTWAFSHGGSRPLQSAPGVYNEQMFQGLDFVISEAKKYGIHLIMSLVNNWDAFGGKKQYVEWAVQRGQKLTSDDDFFTNPMVKGFYKNNVKVVLTRVNTITKVAYKDDPTILSWELINEPRCPSDLSGKTFQNWVLEMAGYLKSIDSNHLLEIGLEGFYGNDMRQYNPNSYIFGTNFISNNQVQGIDFTTIHMYPNQWLPGLTQEAQDKWASQWIQVHIDDSKMLKKPLLIAEFGKSTKTPGYTVAKRDNYFEKIYGTIFNCAKSGGPCGGGLFWQVLGQGMSSFDDGYQVVLQESPSTSRVILLQSLRLSKLS
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAKAAKAAGSSARFRQRKISVKQTLAVLKQSDIPDLEEEQQRELQQIETGVEKGEEEEHHLQAAINSSIAQSTGAKVEKIYIPTPDASQVWKEYDRFYSSSFHEPASYIRTSVTVEETSGCLYNMDDEDAEFLKTCKPPISEDDFEEVMHRFEVTISEKQPFVSIDVSNLLSFEEMAQHIEDGIRQVQEDPTSPEYILAQLQSSLGITVNGTKGKNEGKAFLATFKKIGAVIYPHWRARKVERKGQSIVPHLKFEDHEKDDSDPYVCFRRRELRQVRKTRRTDVLSIERLRRMQAEMETAKQLVEMVATREFTRKAALKAEWDVFEDRCAIKTLKRELGIKGEDEDLVAQKKRKVEPKKEEKAEKASTPVRGGKAAGSAASAQAAAAQAAAAGSGSPSVSSTHVPPNVSIPPSKIPNMDLITIAQVVRDKDEAIAKAVREKLRLRADADRDWHNLTNSGYIPYCEYLNAEVSSSGEPPVPQYSSINEMAYFEKHNASHRYTTKSDFNKDLASMVGNKPFADAQVYGAIVGDDGELRLSDATSTSSPVDRVIPRSSFMSMRKRVGRGGRMWMDRRGLQRNTVLKPSSLAKNSLDDTAESEADEVAMERLADRQKYDRETEPTRQMSSYDKDPSQLNGISSDTQSIRFGSMLLSKAYENYREVFQQRQQQLMMLQQQILQQQQQQQMRNRQQSHPPGDPGAGLGGGQGAGGGAGGSRNNSPAPGTNGPQSKMHNAAPMGYNKQGMTPSQHQQYQQMQQQQQQQQQQQQQRKMGVAPMNAASAAAAMAAQPRRSSGSPDGQRFNGLPNGGAMANGVLPNGMSQRMMPGGDMKQKSELAKVDA
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MYSNEDDDDDSLHSDSKHDTAVADTDGSSRKKRQQISDSDDDEGEDISRPFGSRPEIYSDDDDEDEDDEEGEMTEADKKFIASDDEDADAEEGSDSDRAKRRRRHRRKRARKERQAVEARVVEGDEALSDDELDLIKENMGDTSFNFKRLRKKADEFKNNVDYIFDDDEDIATSMGTETVSTRKRGDDGFRDEDDLADFIIEDDDLDGPEEPDEVRQEKIRRRRERQEFAKNIGTGYGISDESWNDIQELFGDGGDYAYALHPDEIEHDEGEEDDEFLMESQQRKLKNVRLSDVYEPSEIASKMLTEDDDRIRNRDIPERYQLLDQVSTLDDAELASEATFITRLLVKERQNSQTPVTNEALLLSAVTHLVRFIRRDLFEVPFIYMYRKDYFDGILDLPDLWRIVDLNTQFLGIESKKRAVLSLINDILKIDDRINSDIYIRTFVDRLNSFDDVQDAINYLQLTYCIELDAHQNTLQKRRLFKRVAWRRDYEDAKKNNIGGLVNLFNVNIQQYSASMTTQQSLHLPEDHHESPLVAASQFVSPRFPDPESALAAARLVIGQDIAAYPQLRAFIRRVYFVDAVIDVLPTERGKREIVPHHPYYHFKYLKEKPKFSFTDGQFLQIMTAESEGLVVVSVRVEEEPRLLADIMKYICNDYVNDLAEEWNTQRRMIAEYAAKQVIFPLCSKWLKEQLLVSAIEWTALKCQEKLERWVSMSPYRPAQSSDDVHSYDDVAPVVLSITWGEGDRSSPTFAAIIGENGQLSEYLKLDKLNDRERGNDLNMLIDLAARFRPAVVVVGGLKPNTQTQLLRLLEETITAAEVQGKLKENIPVMIVEDEVARIYMHSKRAELEFPIKDYPQLIRYCVSLGRRVQDPTQEFAGLFNVNEDYKSLRIHPLQNLLPDLKRKTVLERALMNAVSLCGVDINAAASNSNLAHTLQFVSGLGPRKSQAIISKIIRSGGKLESRADLIRKNLCAAKVFINCASFLRIRSKHFRQSFSDSVIDVLDDTRVHPEDYDLARKMAADALDLDDTALDEDDTPSQHVAELMESGDADRLNQLLLDDYAIELERRIHQPKLICLNEIRKELIHPYQERRQQFQPASYDEIFSMLTGESDDTLYEGLITSGHIVIIKDRFLFCRLSSGLEGMVHAKNLDIPHGHQSLTELFQINMSIPVCVVGVNKERMTVELSGRVESNATMDEGNIKRDQYFNAAQEHDDIAASKAIKYLAKPKKQVRVIQHPFFKNMDYRAAEEYLSTRPRGEVVVRPSTRGNDHISITWKVDDGLYQHVDVLELEKENEWALGKVLRIDKQAFTEIDQIIAEYIEPMTRRIAQVMNHDKFKRKSLDDMFVYVSEQMAVLKRSAYGFIVVPHKPGMFYLVFRHPQNRPHHDYVIVQPDGLLFRKVKFQSIDDLLAYFKKTEAERSTSVKSRGVAPSTHHLATGVGMHMNPQRQQQYQQQQQQQQQPYQKQHVSSRQPPVGGSRSSKPNPNMTSLSNIRSVPIQHGTGQHVDSRGPSWGDQYTGNSGTLNGGYRGQSSSNGREPRQESSWGEPDGMARGPPLKPHWDQRQDDFHGAQRGGKSDQFQKGSSRDFRGSQPYGNSRSAPQEPSWGGVHDVHNERLGGTSGTSKLNSKDLSWGEPDDTVRRPPPSSSWNETQDPSQENRKIIPQGDTWGEYAPQQTQHTDGW
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MTNFSGGTASVLPPRAPGSLEPDYSTRSIYRDSIRRVSVSSGLCTSARFFLPTGGDTASSAGEGAYCWSSASSASWDASAGWSSVSQSFSSDGDLCFSDWGAADPDGDDELRAIARQMVHDGCMKGLIRGFSAGRSSSSSSAHYGCLGPDSSASREELLLLGSWFSELDVEWVLPTGQGDRTQLQLHLHLEDGCASIQDLTERWIKALKTMVQVLRITQLDLRAKKKPAAGNGIWHFMLLATGKTAEHEQEVAQFTRFAEVSLLRMLDFVDAVADAALNDDHSPETLPGMLQVYTCVVDDSPTVLSLFDEASSTTSTSTSTSMFEAMNDVFLRKRNKLSDAIRSMIEKVTVSFLRDRCIWTASLEEAGGVHKTTMLMMNYVMFLSRIEGALSFGLHDSSPVVNLIKDVISCLEKQLERTSNLISDPGLRYLYLMNNYSFISKKVSSLLLPPWTLMEDYKIEKPRKRDSVRRLPPMEDYVNQPDPNLRAKIETDSNLDGLVKTQSFIEAYLDASWEPVMSCLNHAIPHGFLRCGRALDKFESEFQRTYAMQKHWKVPNPELRKRLRKAIIEKVIPGYSKHLAEQTAKWKSIRQPKNTPLELEQLLEELFEG
The following text describes a protein:
Function:
Required for protein transport from the endoplasmic reticulum to the Golgi apparatus.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus.
Sequence:
MSCIKRVDRSAYVAMAPEAPFMAAGTMAGAVDLSFSSSSNLEIFELDFNSEDHEMKLLGQCSSSERFTRLAWGSYGSGSEETPYGLIAGGLVDGNIGLRNPITLIRSESNESAHVRYLSKHKGPVRALEFNVISPNQLASGDDDGTICIWDLANTSEPSHVLKGSGSYTQGEISSVSWNREFKHVLASTSYNGTTVIWDVNNKKVITGFKNSESSDRFKGLISCSVLQWDPDNCNQIMIASDEDSSPSVKLLDIRYPQSPVRTFVGHHRGVIAMEWCPSDSLYLLTCARDNRTIFWNTKTGQIVAELPTTNNSNFDVHWSPKIPGVVSASSADGNISIYNLEGCSRNGSGENNLIDAAPLLTAPKWWKRPVSASFGFGGKLVSSNSKLPEASVVFLHNLATEQSLVNRITKFETEIVNGEKTSLMSLCKKKSEETESEEEKETWSLLKIMLEEDGNAKTKLRTHLGFSLPSEDQEHYATYSSENVEEEISDPLFDDAIQRSLIVGDYKEAVAHCLSANKMADALVIAHVGGTTLWESTLDKYLKMSNAPYMKVFSAMVNNDLMSLVHTRPAKLWKETLALICTFAEGDEWTSLCDALASHLLPSGFTLAATLCYICAGNVDKTVDIWLRSLEKDNAGESYSERVQDLMEKTIVLALATENKRFSASLHKLFESYAEILASQGLLATAIKFLKLLEPGDFSSELSILRERFSQSFTPAPVTNAEPSRTTLVSLNPPPHQQRTMDFHSSTRYTNATYNPPPGLHLNSKIHQTVVQQVELMVPAQRVAVQPPPAPVAPPPTVQTADTSNVPAHQKHIVATLTRLFKETSDTLGPAKKRDIEGISRKVGSLFAKLNNEDISKHAAEKLSLLCQALDKHDFVAALQIQAHLASTEWDECNFWLLPLKQMIKGRQNVR
The following text describes a protein:
Function:
Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but not toward Ins(1,4)P2, Ins(1)P. Seems to be involved in the abscisic acid (ABA) signaling pathway. Could also be able to hydrolyze PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a donor acceptor splice site.
Sequence:
MAEVRSRSRRTESNWATICCSAFSCLQLYWARIVLRKWFNVSASESDYSADSDDDYEDRSQEFDPISSGVTNPRVDTDGNVIYRPKLRRRNSETFRMQYIDTKAIRICAGTWNVGGRVPSSDLDIDGWLDTLEPADIYVLGLQEIVPLNAGNIFGMEDDQPALEWENLIRDALNRVQPRKLKIKSHSDPPSPSKFKQPEEVPYSVEDMFVETSHDACDGISSMDNKLNSVESTDVPIVSEDSLTNIDVLGSTNDNASCLPIQEYLQRQFSTPNTPDRSLSMQINSDSKREERFSYTERVGLSWPEPPLRLLNQYVSERRGSFKSVNLTITNLRKPSYVRIVSKQMVGVFLTIWVRRNLRKHISNLCVSTVGVGIMGYIGNKGSVSVSMSIYQTPFCFLCTHLSSGEKDTDQEKRNDDVREIHRRTQFLPHSLNANELPRSICNHERIIWLGDLNYRINLSYEKTHELIARKEWQRLVEYDQLSREMTKGNLFEGWSEGTLDFAPTYKYEIDSENYIGDDPESGKRRPAWCDRIIWNGKGMKLFNYRRNEIKLSDHRPVTATFLAEVEVLSPRKLQHALTLTYAEIQGLDA
The following text describes a protein:
Function:
Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nuclear in larval stage. Predominantly cytoplasmic in the adult but translocates into the nucleus following heat shock (By similarity).
Sequence:
MAAAAPKRRMGLEKIGLYDVGRAIGKGNFATVRIARHRIAKTKVAVKSIDVSKLDKENLIKLEREVKIVTMIDHPHIVKCYEIMRVDNMLYIVSEYCSTGELYATLMGKGRVTEDIARKWFTETAAAVSYLHNKGIVHRDLKTENILLGKDSKIKLIDFGFSNFQTPDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYILVTGGFPFGSESVNDLKRSVLSGVVKIPYWVSVECADFIRKMLVLNPTKRMTIQNVLAHRWMHIRNDVKKQVQNLESSIRPTPSKLNPTIMMFMQQHGKWTEEQIIDAVLGRNFESPIFATYELLADKVKIGSLEGTGEEYPRRGSRGSILSGRANVDEQPLTPTISAHQLAQLNLSSPDCDSDDSSNSDLCDESPLSSLEPNHKQFTLPRGLDLMGNRFENRRHTLCASEQLLSPNLMGQFPPPNLLLNNFTMSPLGFPPMPEGQAAEFPFPSLHPALGAFPTTDLSKMLPVPKSERRASAGETLLPTNFDLQQHLANLSANPVSFPTVEEEGRSYLAKYGGKRNTVHCLGNQIGGGVQNPIPRYQRTPYAKAPPAERRSSWASPSLSQQQQSHLEKIFKDALQTNNDISRLHKEFKNLSHGCAQSQITNEGSSLACPQISITDEYNRQHNIAPSASSFDPVSIFQKNAQEVVFGQRPATAIGFSSTSFSGMSTPEQTTRSMDDRVRSIVCTLPFAEVVEELKSSLNILKIPFAETQEMVYEPQVTEMRRLSLPSGVEIGVAVLPPEHKSHVEFAIINNDSPTSEILCDQLICRLRMIDPNWSSE