lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSRSLWRARGFHSSVQVAAKLGSSRFRKTEPAVPAPVKEAPSVDQAKALSRNQPRSQGQNQGQNSNQNQPRGQNQRGGQNRNNNNGNKNNQGTNQGQNQGQNQNRNQNRNNNNNNNNNNRQQRSQKPTINLAQAETPSLMKIMRKQEEARAKKSFNTPNMSGPGEKKGGEGGKKSHEAGKKGEEKPKNVFLRHEDFVVATPKTVPPPPVKEKKVKEIEIVRPRLAIPSFVSISNLATILQVSLETLSSTMVELGFDQETTDHNHVLDGETAQLIADDLGFDVYTNETQGVDLFLAPKPSADEKSKLPLRPPIVTIMGHVDHGKTTLLDYIRKSSVAEKEHGGITQHIGAFSVKAPKSGKQITFLDTPGHAAFLKMRERGATVTDIVILVVAGDDSVMPQTKEAIKHVHAAGVELVVAINKCDKESVTEETIQKVYSDLGANEVYVEDYGGDIACVQVSGKSGLGVDTLEETLVAISEVLDLRSSPTAKVEGIVLESQVKKGVGATATVLVHNGTLKPGQVICAGTVFCKVKAMKDSSNKVIKEAGPGTPVEVTGWKELPASGDQVLQAESEQQAKQVAENRQKRAQLMQQMDDIKIINEKRKQQKIDQEAEEKRLERAKLGLPPIEEDEPEAKCQLAHFIVRGDVHGSVEAVSESIADIGNDEVHVNILSRSVGPPTANDVEIARTANASLLLFNVKPTRDVILKARQAGVPIIEQTIIYRVIEHVTEHVTSLLPKIIRDKEIASAQVKDIFEISIAKKKVKIAGCRVTMGPLRRSHTVKVMRDGEEVFRGTVSSLKHNKDDVTEMAKGQECGIALEKWDELESGDIIIAVEDEEVPRYL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
Sequence:
MPQITSRIGRRLGETRWMLRIWALNRNAIVFGNSSSPGSVIVAELAHHNLDIKRVAILFAGGPAPAANAVISTAAFSFLEEGAQVFGIKHGYSRLAEYTAAGPLQEGTDYIRFTHDSLTHARSSRGIMIGTARTNPGKHVSSPEHLKDPELVAPLRRVYEGLCSLEVDALISIGGDDTLKTANKLKMFQDNLPGDARRFPVVHLPKTIDNDYSGIDFTFGFFTAVETLAEEIRNLNYDAAAGRAYFLCEAMGRSAGWLAYGAAIAGEASMVLSVEDITGALADEEVVNQETGETRKIMAMDRVIDRMVDMMLAREREGRQYGTIVIAEGMAEYLPAKYLEGVTRDDHGHINISLVNLSAVMSRLLAARYNERTGRTRKVNGLQMGYESRCAPPHAYDVMLGSQLGVGAYRALVEEKLNGVMVSVSGQFDLHFVPFEELVDPQTLVTKVRFIEQNSDFHRLARFLETCVDN
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MSAPPRLSARTSILDQKKNAANTSSTQLKSSSGISSSTPSGTSSIGSSSGLKSSGGFSATSSTSSSPNISKRNSANLSQQYQQSTTLSSPPFKSPTNAPSPSSSSPFSYFSKQTSAQNLAMLIYQDYVDEQLFYNSPTEQDDEEFDHIRNLLNSEYSVTTVQSTGALKSNNLVVMSWKNNATIEQSEQDEQIENDKRDLNFIKDQLAKNNSMSKQMVYILDRFNDGLSLLENEVAPINASMKEWSSIFNNINSTMDMVKSTLEKFDVDKIESKIKEGAKGDYISYMAALEHVGGAIDYLNEHNQFKSADKVINSLKDLKQFGLNELESNFKSLLLKISNITDPTTIPKLPNSKRYLAIISPSLIEEISKSIELFEKLHFTSFLKEYKDKRSKFILLSLRKMGPEKFIKQTSETKNLAYVKGSHPLISYVSETLRLYQIESDLASEFFGNQYHTILEEIIDPAHELLLETTEPIIKVKKTPGDKVFSIFPLLDLFDTFTTLLPDFISSISARDGKHISELKTQIKHLQETCASLLDFSLEDDREQRSKDSVITDATVDEISSNMLNYFKRLIEYKSSVELLLKSQQSASSSSSSSSSSSSSSSQTFYTFLEKILKSLIKYLQTRAKKDFSSQPATDFFKPPIKSVIFLINNYRYIASSLKQSNILGDSENVNNNNNNAILHEFETCLDNETKVFNSFWKTITDILVITKTGKDKDDTKAVIKKHTNFLKTLNDLNKLKFDIPDLELKQKLKTDSKNIISKSYDNFKEACRLEKIHLEKNFTPFETTDDINRKIEKIFDSQ
The following text describes a protein:
Function:
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Nucleus. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta. Interaction with FOXK1 and FOXK2 induces nuclear translocation (By similarity).
Domain:
The DIX domain mediates homooligomerization.
Sequence:
MAGSSAGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDTPQPEVAPPAHESRTELVPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRDRPRRRDSSEHGAGGHRPGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRMERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESELSSRGGSLRRGGEPGGTGDGGPPPSRGSTGAPPNLRALPGLHPYGAPSGMALPYNPMMVVMMPPPPPPVSTAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Sequence:
FPDNLLADSVAVTSALQSACGPGVRFFIMADTTFGSCCVDEVAAAHVNADCVVHYGPACLSPVTNLPAYFVFLRTPLDINTCGEVVADLVAKDERLLVLYDLEYAHAIPELRETVRQEAPENSGLTFAEIIGRELNPCKCDKEPILDNDEHSIGGLKWKGSTPTKILWIGKEGPALINVMLTYNSAATVRYDPASGEQTSIFYSQYLIFNIEFSRYYLIERAKDANIVGIVVGTLGVAGYKQAIQNVKQMVKSAGKKSYTLAVGKPNPAKLANFPECDVFVLIACPQTALVDNKEFFAPLLTTFEAQLAFVRGKQWTGSYSLDFRDVQLPADPQDSTTEEEPRFSFISGGYVSSRTGETKRFLLFSQVNLH
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mL54 may have a meiosis-specific role as it accumulates during the middle stage of sporulation.
Miscellaneous:
MISCELLANEOUS: Present with 1100 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLARSLGYRLISTSRILYNKPTVKSVVSSCPAGTSLNLNIWKSGKDAVALEDKEYPNWLWSVLDSDHVVEHAAEDPEGQALLKRRKNIRKANRQRIKQNNFLSQL
The following text describes a protein:
Function:
Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane. Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor. Acts in concert with an unknown phospholipase A1 to convert palmitate PE species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span. Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (By similarity). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols. Has no activity toward lysophosphatidic acids (LPA) and lysophosphatidylcholines (LPC).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MAVTVEEAPWLGWIVAKALMRFAFMVANNLVAIPSYICYVIILQPLRVLDSKRFWYIEGLMYKWLLGMVASWGWYAGYTVMEWGEDIKAIAKDEAVMLVNHQATGDVCTLMMCLQDKGPVVAQMMWLMDHIFKYTNFGIVSLIHGDFFIRQGRAYRDQQLLVLKKHLEHNYRSRDRKWIVLFPEGGFLRKRRETSQAFAKKNNLPFLTHVTLPRFGATNIILKALVARQENGSPAGGDARGLECKSRGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIGDVPLETEDLTSWLYQRFIEKEDLLSHFYKTGAFPPPQGQKEAVCREMTLSNMWIFLIQSFAFLSGYLWYHIIQYFYHCLF
The following text describes a protein:
Function:
Probable transcriptional regulator involved in cell adhesion.
Subcellular Localization:
Nucleus.
Sequence:
MVANYASMMYHNGSNILGYGVLRLLQYNEQLMSGWESTMKDDIGYWRRFVHDFYTEKGTFRYNIDYKDSPNQEPKLFELSYAALPRFLYLSYCGKLKKMSFLLGNTKEFAIPNNGYFVESSRASILYQYQGGVQVIVSGHLRAHFFRAPLLKLDSLEFSAVGHSEYLLRELMTNASLALSQSRPPQNQIQHDGVKSEDPSSESVNINSSSSLLPDSPVNEYGLEPHIMRFMEITETISGMRDLIAFTLAQRSGPTSALHKFATALQQQHQMQKSTSSNIPYANPAPSGFNGSPRNGDVASLASNYRYAKQPPTMPANAISQANRLLDQNNIPNMDPSILPQSMPIASVPPYSLQGIKRQGTHSPMVEGENPNNNPNFYSSDMLNAQKRTKV
The following text describes a protein:
Function:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrium between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAACLRRVVLQAGRQGSCCLGFSSPAWQQSPVGSLWRLAAQPRGVLPGPAWSRAARPLTTASSEEEEEEGRTAKKKQDPRARKTVGSVGRKIHHRVVRVISELGEDLGPLHRADVIRIMDQRELKLVPLRENEEPPVYRLMTGKQIHEEQLKLRERQKAQPAPTQVKELTLSSDIARRDLDTKVKQIQSWVEKKLHVKVTVRKGSPAAEIAELEGVLEQVAQHLAGVATFISKPKAIKDGKAAMGTLRALSRAELSKLKSQEKQQLLLKEQDQVPETLTKDPQDKVLQS
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MGGFDYLQKGGTGFTLQVKKPQIRRVVQTRPAAPSPSANKATPRTVPSGPQKKTPETASRSVTGERGFSPSKRRLTPLRNRKRPTPEQRLSSDDDDDGSDTDTSLELRKRARTGESAEPDYGRRLRSLKAFSGDETRSLPIVHASEITSVQKPGKFKPAFENMNQTSEIFLQYPSATPKERYEAVVPRDDDEFKPLDDIVQVIETVTQAYIPEDELDEFNNESTGIKRRLRRALARGSEREFRESVKDYNVAIERLRRSGSIAKKLDATYRLSLPHVERILTQIYSRTVSPRVDSLRQYENGTDNVYGELLPRFISTIFKETGLKSNHVFVDLGSGVGNVVLQAALEIGCESWGCEMMQNACDLAELQQAEFKARCRLWGIAPGKTHLVRGDFLKEQSIIDVLKRADVVLINNQAFTPQLNNELINHFLDMKEGCQIVSLKSFVPVGHKIQSRNLNSPINLLTVKQRQYWSNSVSWTDVGGSYFIATKDSSRLKAFSESLA
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVLPAAARCKGTMLGRLVWILLLFGLLLLSGFCEACKKITFNVPHKLDAGMFIGRVNMKLCFQHFGIISSNNPNFTVLNDSLLYTTTAMSLSSHENTIALSFKGIDENEPRMIYVNLQTYSGKTARDNARRVREAVVSRTKRRWAPVPTIIMENSLGPFPMQIQQLSSDMAQKYNIKYSITGPGVDQVPLHYFYIEEDTGNLFVTCPIDREEYPEFQLICYAVTSDGYTPEVPLVHIIRIEDDNDNAPEFDHDIYTFHVLENSRIGTLVGQVTATDKDEPDTLHTKLKYRILSQHLLSPQTSALFAIHPDTGCITVASPHLDRETTSEYLLQVEVRDMGGQDFGLCNTAKVLIVIGDVNDNPPQLLHTMYEVSLLENTVNAELLCIPVSDSDEPGTPSWLASFTIIKGNEDNSFAINVDQERNVGCLVVLKGLDYEKAKERRLEIVVNNEAPYAPPPNARAISKSMVTVVVNIKDQDEGPVFEPCEYNLYIKEGLPTGTVVGNYKAKDPETGSSEGLSYRLISDPCNWIIIDRRGDLTITKVLDRDVPDNKQNHCNVTVSATDQSGKSGIGEIVMTLIDENDNYPVVTKKNYTMCKNKKPVCVTAIDKDIPPNTTPFHFEIETPTDSTWKITPHEDASALILPVADIDYGHYPILLRVYDNGGSSGTSEIMIHYCDCVIPSECVSQLSPVVPLNAAVDSTYAEYSTSFVPWGAVSTVFGSALLMLGMGAPVGYWYRKRGSTHHVVADDVAAPNLITSNTEAPGDILTDVNIFPVKTVSGSMSTILERNVKGENVAMVKGERGSTAELVKGGKSHMSGSLRHIALPLRNSYKDICAEWQDFTNPHLSEMVYLCGQDEEGKHVEEYLLPYTYEGKESPVGTLSSCTGESEEEELDFLNEPEPPFRTLAETFANSLGSTPDQTLLK
The following text describes a protein:
Function:
Component of the Bil (bacterial ISG15-like) antiviral defense system, composed of BilA, BilB, BilC and BilD. The Bil system specifically conjugates a ubiquitin-like moiety (bilA) to the bacteriophage central tail fiber (CTF, or tip attachment protein J) via reactions involving E1 (bilD) and E2 (bilB). Modifies CTF of phage SECphi27 and SECphi4, which probably interferes with assembly of the phage tail. Also modifies T5 baseplate hub protein pb3 (gene D16), but not gp27 of phage T6 (Bil defends against T6). BilC is a probable metalloprotease that may cleave non-specifically conjugated targets (Probable). Bil-encoding bacteria produce mostly defective phage SECphi27, many of which have phage assembly defects, including no tails. SECphi27 phage progeny produced in E.coli with the Bil system inject less DNA into naive host cells, maybe because the phage are less able to adsorb and inject their DNA into host cells; Expression of the Bil system in E.coli (strain MG1655) confers about 100-fold resistance to phage SECphi27, SECphi18, SECphi6, SECphi4 and T5, but not to SECphi17. When cells expressing the Bil system are infected by phage SECphi27 at low multiplicity of infection (0.03 MOI) the culture survives, at 3.0 MOI the culture collapses at the same time as cells without the Bil system; Cleaves a ubiquitin-GFP (Ubl-GFP) fusion protein in vivo.
Sequence:
MNFSIKATIRAWSAPEHKLACRKQLWRKIVAELERRGKRRHEAGTFLLGIERNGRKEVQSAVYYDDLDPSAYDSGVCILHGDAFAKLWSHCREKGLTVVADVHTHPGAGFQSDSDRTNPMVARQGHIAIILPNFARWPIRQGNLGIYEYCGQHEWLERSPAHAPNFFYTGFWS
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are usually held in an inactive form by an anti-sigma factor until released (Probable). ECF sigma factor involved in aerial mycelium formation, required for translation from the bldMp1 promoter. Expressed as a preprotein; processing and accumulation of the mature protein starts as aerial mycelium formation and sporulation commence. Activates expression of about 17 genes, including those for rdlA and most of the chaplins (chpA to chpH); chaplin activation is indirect.
Miscellaneous:
MISCELLANEOUS: A mutation in the promoter region (called R112) carries a GGAG to GGAA change in the putative ribosome binding site that reduces complementarity to the 3' end of the 16S rRNA; this is presumably very poorly translated. R112 colonies are white and produce long, straight, undifferentiated hyphae, with rare spore chains observed, sometimes showing highly irregular septum placement. Additional pleiotropic effects are seen such as substantially reduced aerial mycelium. The R650 mutation (Gly-103 to Asp) probably interacts less efficiently with core RNA polymerase.
Sequence:
MYPHVGVDASGLATLRATVKSAQDLLRGFVPTAYAVPALAAAAVPAGPCYALAEGSAVVGRRARSSSSGAAATTHRRPAADSDSARMMELVERAQAGEADAFGRLYDQYSDTVYRYIYYRVGGKATAEDLTSETFLRALRRIGTFTYQGRDFGAWLVTIARNLVADHFKSSRFRLEVTTGEMLDANEVERSPEDSVLESLSNAALLDAVRRLNPQQQECVTLRFLQGLSVAETARVMGKNEGAIKTLQYRAVRTLARLLPDDAR
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
Miscellaneous:
MISCELLANEOUS: Three different forms exist, PSRP-5 alpha, PSRP-5 beta and PSRP-5 gamma, due to different transit peptide cleavage.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALLSPLLSLSSVPPITSIAVSSSSFPIKLQNVSVALLPSFGQRLVAHGPVIAQKRGTVVAMVSAAAEETAGEDGDQSKVEEANISVQNLPLESKLQLKLEQKIKMKMAKKIRLRRNRLMRKRKLRKRGAWPPSKMKKLKNV
The following text describes a protein:
Function:
Probable transcription factor required to initiate organ founder cells in a lateral domain of shoot meristems. Involved in the lateral sepal axis-dependent development of flowers, probably by regulating the proliferation of L1 cells at the lateral region of flower primordia. Required for the formation of the margin cells of the first and second whorl organs.
Subcellular Localization:
Nucleus.
Sequence:
MSPVASTRWCPTPEQLMILEEMYRSGIRTPNAVQIQQITAHLAFYGRIEGKNVFYWFQNHKARDRQKLRKKLAKQLHQQQHQLQLQLQQIKPKPISSMISQPVNKNIIDHHNPYHHHHHNHHHNHHRPYDHMSFDCCSHPSPMCLPHQGTGVGEAPSKVMNEYYCTKSGAEEILMQKSITGPNSSYGRDWMMMMDMGPRPSYPSSSSSPISCCNMMMSSPKIPLKTLELFPISSINSKQDSTKL
The following text describes a protein:
Function:
Regulates diverse developmental processes including larval molting and gonad maturation; [Isoform b]: Promotes the localization of myrf-1 and myrf-2 to the cell membrane. In association with myrf-1, promotes the synaptic remodeling of DD GABAergic motor neurons whereby new synapses form in the dorsal processes of DD neurons.
Subcellular Localization:
Cytoplasm. Apical cell membrane; Single-pass type I membrane protein. Note=Detected throughout the cytoplasm in germline and somatic blastomeres during embryogenesis and in germline and somatic tissue in adult hermaphrodites. Localizes to P-granules in L1 larval Z2 and Z3 germline precursor cells. Expression in P-granules is most pronounced during the meiotic stage of the germline; in mature oocytes and sperm expression switches to a cytoplasmic pattern.
Sequence:
MRSLLSFVLLALARIAISEETKSCIDIEKGFKEEFNAHKQPVCICADNGIFSTVKGFTIECESASIASVSENLASLNGTELGRLTIRDSTVNVLPQDLFENVFAKQVKLERCGLSTLQPNSFQSLGGSAELLSLRENRIKKLEKGLFTGLKSLKTLDLAMNKIQEIDVGAFEELKKVEELLLNENDIRVLKTGTFDGMKNLKKLTLQNCNLEIIQKGAFRGLNSLEQLILSNNNLENIDWTIFSALKNLRVLDLGSNKISNVEMKSFPKLEKLVLNNNTIDSMKSIKLKDLPSLVVALFDRNKIESIGDMDMFGLTRSDRIETLSLARNNLSQISPKAFQHTPNLITLLLQYNQIEELSSHSPSQVRTPFLASLKKLVTLQLSSNNLSVIRSDELPKSLSSLALDHNVISKIEARALEGMEIKRLYLHSNKLNYLYQGTFDSFSPKSVEAVDVSLNPWVCVCNDPKEWLPRWLEASEEADVAEGALGCLAIPNCGQKEGSTVMPEEEEVYRSGWITVAATILTIVTIVIMVIIAMLYFKDARYQFPLRGRRSDSDLHKLIENDPLNIASDSILVVPAMPKRNTGPKKTVRFQNF
The following text describes a protein:
Function:
E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRSSWDNMDYVWEEEDEEEDLDYYLGDMEEDLRGEDEEDEEEVLEEDEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVSDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRMTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQVSNVPSLFPQCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. Plays an important role in the uptake of multiple carbon sources such acetate, lactate, amino acids or GlcNAc present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MVQSMTSVVKAANFILARPTLSKIITPLAQKFTAYAGYREMGLKFNDLLLEETPIMQTAIKRLPSELNYSRNFRILTAHQLALSHQLLPAEKAVKPEEDDNYLIPYILEAEKEAFEKAELDNIEVKA
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATTATQDGAAATEEVKLDLFEDDDEFEEFENGEWDDKEEEDALQPWEDDWDDDDVNDDFSQQLRAELEKNDSKCAHRDANSSKFGHKEALHHNQVLGGGAGEPSMSSQDWH
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSQTQEPCKHPVQLFGMCAVCGQPVDADSEESASLSVMHSSSAVKVSAEEAQRLDSETTSHLLSQRKLALIVDLDQTVIHATVDPTVGEWMRDESNPNYEALQSVGKFRLGIDGEEIKDEEDGSEPKDPAAALKASRACWYYVKPRPGVPQVLKHLSEKYELHVYTMGTRSYANCVCKLIDPDASIFGNRILSRDENGSLVRKSLSRLFPVDHSMVVIIDDREDVWSRSPNLLPVLPYEFFVGIGDINATFLPTPPPSPGALPEVIASGAANKANDAPTVAALSTSGSEARSSNDGTDATTPERAVEEAAQKAEAEGRSEDELQALREAAAHFVAQTEKLQSKLAEQREARPLARMQEALDEKLGRHSNGASRSGTATPNGNSDEHNGQTSEADSSGSDSETGAGDHNRADAATAAAGMLEDMAASVNNSTGATSRLSSGTGLPPLLPPPPPLPPHRSHAVLVDDDNELDRVQSILDDLHAQWYAKYDFMQSATDAAASNAAMLKPSVVDLIGMKKAQVLKGCTIVFSSMIPFGHNVEKSDLWAMAREFGATPASEIEVGVTTHVVAARPGTAKVHQALRLSGQLEVVWPSWFHVSASRWSRQDEALYRISEGENALASANAKAEAQVANQRVQDQTSSLAANEEAQAQVAELTREDPDESLFENELNDMDWGAAADEVDAYLDSATTASNTSSPSPSMHDDDEQVDVHHTNAPLQGDSRKRLRPDDVPSTDLANSQTSKKQRPQSDAGDNNNDDDDDDADDGFLDHLAEELDGQIDNE
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MWSHTLVPILILVTTYGVNCHENSGEKRADYSGYTLHRFKVDTSSDTMEKLEGYDMQLDKTTQTARLLIDIWAEPSKQNPYADILVAPEFLQKFKSLLTSAELSTLKMLEGDIQSQINAERHAMIRNSVRRRKRAMKTWQEFDTNAYHSYNEMVEFMKLLSEQKSDMVEMVKVATSSEGRSIYGVKIHPPGPSPPEKPSIIVDAGVHAREWIAPAVGLFMIRKIVEEYGRNPQVTANLQKFDWYIMPQVNPDGYEYSRTTDRLWRKTRSKNVTVNRWCVGADANRNWGYRWGEAGANRTPCSNIYMGSHPYSEPEIRGLKEFFTWQITNPMVYISLHSYGQLLLSPWGYTNERTENYQDQQNAAKEAAQAIKNTTGVSYSYGTISEMMYPASGTSIDFMQHRGVPYIYGVELRPTDNPNSFAFNLPPSYIRATGDEMLAALNAIGTHAVKVKRL
The following text describes a protein:
Function:
Probable transcription factor required to initiate organ founder cells in a lateral domain of shoot meristems. Involved in leaf formation.
Subcellular Localization:
Nucleus.
Sequence:
MGSHSHLGQALQAHHHHHHHHRGGECEPATAAAARSRWAPKPEQILILESIFNSGMVNPAKDETARIRRLLERFGAVRDANVFYWFQNRRSRSRRRARQLQQQQAGSGPQHPTAAAAAGHVHGANANDGVSLYAMHGHAGQQQQARAAGLPAVAPVVLPPAAVASSPRFFGDEIDTDGGDDLFAISRQMGLMSRGGEQHGCGYVANNDASQSHLLSYQPTGTATTAAAAYIQVSINGVVYEVPGAGALLDLAGTFGRDAMLVHSSGEILPVNENGVLMKSLQMGECYYLVSKST
The following text describes a protein:
Function:
Alternative, nonproton pumping NADH:quinone oxidoreductase that delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones, and contributes to the regeneration of NAD(+).
Subcellular Localization:
Cell membrane.
Sequence:
MAQDRKKVLVLGAGYAGLQTVTKLQKAISTEEAEITLINKNEYHYEATWLHEASAGTLNYEDVLYPVESVLKKDKVNFVQAEVTKIDRDAKKVETNQGIYDFDILVVALGFVSETFGIEGMKDHAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGELTDRIPELCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYLEDRGVEFKIATPIVACNEKGFVVEVDGEKQQLNAGTSVWAAGVRGSKLMEESFEGVKRGRIVTKQDLTINGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNIKRILNGESTEEFEYVDRGTVCSLGSHDGVGMVFGKPIAGKKAAFMKKVIDTRAVFKIGGIGLAFKKGKF
The following text describes a protein:
Function:
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MAQGSGKSVLFVCLGNICRSPIAEAVFRKLVTDAGISKEWTIDSAATSTYEIGNPPDYRGQACMKNHGIPMSHTARQITSNDFLSYDYILCMDESNLRDLKKKGGQVQNCKAKIELLGSYDPQKKLIIEDPYYGRDEDFETVYQQCVRCCKSFLEKSS