lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MTEGLEMGKDPNDSTHSRSLFVREDGSSISFYVRPGPAKRRLSSLILHGGGSLCRVQEPEAVLLAQPGELQAEASGDFISTQYITDCVERNERLELEDYRLGRRDSESPEPASGEPGDAFTEAEDLAIVRYVKDNSRSPSSQTGNTLWKALEKAALTQHPWQAMKDRYLKHLKGLEYKHLEGEEPASPSQKLKRKADETEPADWGNEPQKKKNPDLPEEDSPEEQVQDSEITEEDVHDQTPDLELIASKDDEVIEDAVVLETQLEAEESSSSPSSLSPDVGAAIKVIRHLMEEFSVDLATVTQAFLKNSGELEATCSFLQTGQRSDGYPIWTRQDDVDLQKDDENTRSKLIKKFGAKNVARRIEFRSN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDQWEGDPAEDSDAKQLVAGGMEESAKPNDVTVCFSVEELDSLEDGQRDHNKNLKTKVHHSPNLVGYLYVKPEIVPRIRRGEGLCVSSDLYTEKRRNRAYLTAGESASRSEEGRRSPAVRSAQSYHSGGHRTPKSLFRNLEQQTGPAEDEKPSESGALIASTAELDKPQGVTQQRNRRARRFRCGECGDFFREHSHFIQHQETHTRQESTFTEHGESLLSSRVQTAGDSSSYPECSVDSRDGPKPTTHRRNPTEAKSYTCKVCGKNFTQNASLIVHQRTHTGERPHNCKVCGKSFISGSYLVMHQRVHTGERPYACSECGKRFISSSNLIIHQRVHTGEKPYLCTECGKCFGHSSHLVRHQKVHTGERPFTCAECGKAFSRSSHLVRHQIIHMRNPANQAM
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Sequence:
MLQLRWLVLFLSVFSFVSLRAPVAIAAASIARTIVVNLKGGGDFKSIQQAIDSVPDNNNKWTKIHVGAGVYREKVNVKSTKSYIVLEGDGAQTTSIEWGDYNGDSSGHDTNTSATFTSYASNFVAKRITFKNTYNGFAKLTPAVAAWIFGDKSSFYYCSFIGFQDTLADTLGRQYFKGCYIEGVTDFIFGYGQSIYERCKISTVKSLEKPGYVTAQGRNNASDNSGFVFKWCTISGPQATYLGRAWKHYSRVIFYQTFMSAIIVPEGWYIWFSKGYEGVVTFAESGCTGPGSDLSGRVMWEKQLSDDELKKFIDISYIDGEGWLEAQPPLD
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
Subcellular Localization:
[Processed zona pellucida sperm-binding protein 1]: Zona pellucida; Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Sequence:
MAWGCFVVLLLLVAAPLRLGQHLHLKPGFQYSYDCGVQGMQLLVFPRPNQTIQFKVLDEFGNRFEVNNCSICYHWVISEAQKPAVFSADYKGCHVLEKQDGRFHLRVFIQAVLPNGRVDTAQDVTLICPKPDHILTPESYLAPPTTPQPFIPHTFALHPISGHTLAGSGHTGLTTLYPETHPTPAPPSSEPGPVGPTVPQSQWGTLGSWELTELDSIGTHLLQERCQVASGHIPCMVKGSSEEACQQAGCCYDNTKEMPCYYGNTVTLQCFRSGYFTLVMSQETALTHGVMLDNVHLAYAPNGCPPTQKTSAFVVFHVPLTLCGTAIQVVGKQLVYENQLVSNIEVQTGPQGSITRDGVFRLHVRCIFNASDFLPIRASIFSPQPPAPVTRSGPLRLELRIATDKTFSSYYQGSDYPLVRLLQEPVYIEVRLLQRTDPGLALMLHQCWATPSASPFEQPQWPILSDGCPFKGDNYRTQMVAADRATLPFWSHYQRFTIATFTLLDSSSQNALRGQVYFFCSASACHPVGSETCSTTCDSEIARHRRSSGHHNSTIRALDIVSSPGAVGFEDAPKLEPSGSTRNSGSRPLLWVLQLLALTLVLGDGVLVGLSWAWAWA
The following text describes a protein:
Function:
Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSHQQIIQTLIEWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGEYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRREFDRTPSDYRHRL
The following text describes a protein:
Function:
Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microcin J25, with the help of the outer membrane channel TolC.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MELLVLVWRQYRWPFISVMALSLASAALGIGLIAFINQRLIETADTSLLVLPEFLGLLLLLMAVTLGSQLALTTLGHHFVYRLRSEFIKRILDTHVERIEQLGSASLLAGLTSDVRNITIAFVRLPELVQGIILTIGSAAYLWMLSGKMLLVTAIWMAITIWGGFVLVARVYKHMATLRETEDKLYTDFQTVLEGRKELTLNRERAEYVFNNLYIPDAQEYRHHIIRADTFHLSAVNWSNIMMLGAIGLVFWMANSLGWADTNVAATYSLTLLFLRTPLLSAVGALPTLLTAQVAFNKLNKFALAPFKAEFPRPQAFPNWQTLELRNVTFAYQDNAFSVGPINLTIKRGELLFLIGGNGSGKSTLAMLLTGLYQPQSGEILLDGKPVSGEQPEDYRKLFSAVFTDVWLFDQLLGPEGKPANPQLVEKWLAQLKMAHKLELSNGRIVNLKLSKGQKKRVALLLALAEERDIILLDEWAADQDPHFRREFYQVLLPLMQEMGKTIFAISHDDHYFIHADRLLEMRNGQLSELTGEERDAASRDAVARTA
The following text describes a protein:
Function:
Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate. DpgC performed a net four-electron oxidation of the benzylic carbon of DPA-CoA and the hydrolysis of the thioester bond to generate free CoA. It can also use phenylacetyl-CoA (PA-CoA) as substrate.
Sequence:
MTTDSPTLSLSPGLDHRALAKAAQRVDELLDGLPSPSARTPAQREAASSALDEIRAARTEYVEAHAEEIYDRLTDGRTRYLRLDELVRAAASAYPGLVPTEAQMAAERSRRQAEKEGREIDQGIFLRGILSAPKAGPHLLDAMLRPTARALELLPEFVETGVVRMEAASLERRDGVAYLTLCRDDCLNAEDAQQVDDMETAVDLALLDPAVRVGMLRGGVMSHPRYAGRRVFCAGINLKKLSSGDIPLVDFLLRRELGYIHKIVRGVATDGSWRARVIDKPWLAAVDSFAIGGGAQLLLVFDHVVAASDAYFSLPAATEGIIPGAANYRLSRFTGPRLARQVILGGRRITADEPDARLLVDQVVPPEEMDAAIESALAALDGDAVRANRRMVNLAEEPPDGFRRYMAEFALQQALRIYGADVIGKVGGFAAGSR
The following text describes a protein:
Function:
May transport divalent cations (By similarity). May participate, with dstA, in the regulation of the differentiation of stalk cells during development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTSLETYNDNVKTALIMCFLSGLSTAIGGLYVIFIKQQSHKLLGHLLSFSSGVMIYISFMDLLPESIAEIGFYNANIWFFVGIIFFAVILRFVPHDHDESGDSNHAHSHNGASIEKHSSEKKEVVDDDDDDNNGKDKKQKQQKQKQQKQQQQQKQNIAKSKNKKKSKDDYLNSVGIATAIGVSLHNFPEGVAVYLACLKGIDVGLPLMLAIAAHNIPEGMAVAAPIFSATGSKWKAFKYCLYSGLCEPVGAIIFGLIFKEYMTPYLIQSMLAAVAGIMVFMVIKELLPAAFKYVSVDESAFSNIIGMIFFFFSIHFLHSMLPHDHGGAGDGGHGHSHGGHGHSHGHGHSHGGHSHDSQHVESPQSSSFNAFA
The following text describes a protein:
Function:
Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (By similarity). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity).
Miscellaneous:
MISCELLANEOUS: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
Subcellular Localization:
Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side. Secreted.
Domain:
The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
Sequence:
MAAEDVVATGADPSELEGGGLLQEIFTSPLNLLLLGLCIFLLYKIVRGDQPGASGDNDDDEPPPLPRLKPRDFTPAELRRYDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLNDWDSQFTFKYHHVGKLLKEGEEPTVYSDDEEPKDEAARKSD
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MLGKEWSALLQLVQHSTAVFSIIINTFLIYLILTKSPKQLGAYKWLMVYISVFEIFYSILDVVLVPQHYSHGSTFLVIVGIKEKILGPGGLLILNACYWGCYGASMAVFSLHFIYRWLVVTENPLLETFNGWKIILWFSIPLWYALVWISTGYILSAPNESTSRYIKDSVKEIFGLEFDEYVYLGPYLYEKAVNGNIHVAIKALLSLGIISVTIVSSLIIVLAFGILCYQKINQLVATTAASVKLIKLQRQLFYALVVQTIVPFVLMHIPGAIMIAFVFLDIDLGVYSAVLSMTIAIYPAVDPIPTLIIVENYRKTILEFCGCVKKSRISVTSTVERPKSVMISSNI
The following text describes a protein:
Function:
Putative protein methyltransferase using S-adenosyl-L-methionine as the methyl donor. May methylate a Gln residue in target proteins (By similarity).
Sequence:
MIIEIEGIKLKLHPEVYEPAEDSILLLKNLVDVKNKDVLEIGVGTGLISIACAKKGAKKIVGVDINPYAVKLAKENAKLNNVNISFFESDLFENVTGKFDVILFNPPYLPTSEDEKIDSYLNFAFDGGKDGREILDRFIYELPNYLKKGGVVQILQSSLTGEKETINKLKPLGFKVEISARLKVPFEELMVINAWRL
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes.
Subcellular Localization:
Nucleus.
Sequence:
MRRKIPPLRRKMKKLEEEQKVARGRERDFSLKNTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS
The following text describes a protein:
Function:
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVAAGGPAGAAIPESRLMALGILGGLAGIYASAVNPVIGPVLASLGAVCAIVWGADAIRRVASYGLGTGVPSIGYMSVSIGIVGVVAGLASVFVVPAIAVPVVALILAMILGVVVAVLGKKIVKMKIPILEKCTAEISGAAALSVLGFSAAIAGSYTLQTMLTSVITTGFIGLLFILNTMAIQHPFNACLGPNENQTRTLKLAASTGFISMAIVGLLGIGLNPSWWLVSLIGALCWIVAFRAFVSASFEEAASVKWSGLWPKEEEH
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MKKEDLRIVYMGTPDFAVEALRQLVEGGYNVVGVITMPDKPAGRGHKIQYSPVKQYALEQNLPLLQPEKLKDEAFVQALREWKADLQIVVAFRMLPEVVWNMPRLGTFNLHASLLPQYRGAAPINWAVINGDTETGITTFFLQHEIDTGKVIQQVRVPIADTDNVEVVHDKLMILGGKLVLETVDAILNDTVKPIAQEDMAVVGELRPAPKIFKETCRIDWNSPVKKVYDFIRGLSPYPAAWSELVSPEGEAVVMKIFESEKIYEAHQLPVGTVVTDGKKYIKVAVPDGFVSVLSLQLPGKKRLKTDELLRGFRLSDGYKMN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPRRIDKVSSMTKGHITMSMNKLNLFNIYRKDPLQYFGKTLYQQKWAAKTETRNYHGQQIKEKRFKNVLFDSNLKTYSQLDASLKGHDVAPTPITLQTYGTLEKRLEIALFRSMFASSVRQARQFILGGYVKVNGVVIKHPSFPLQSGDVFSVDPEKVLFALGKTKPSLEKALSVDKKQIKKWNNYVFEAKKNPEKIWDLKQNKPDSLDTLKQVEDFEKQKKSVQNAQKLMKIQQNQVTRQSILQEIIQLGNAASEPASLETFNKYGDVARTKCLQIYQTLTNKNHPITKDPSTKNIEGFLAKDENKSPEEKHEVRLINSTLRELQSSEWERIRIQFENFEEGTDTKFFQTSFAKALRGVPKLNKEEILEDESKAKVQLPWQKHLFGRKDPSRSYFTPWTPRPFLGAFAILPSHIEISFDTCHAIYLRDPVARPGHSEVISPFPDHVHERAYMYYVRKGKS
The following text describes a protein:
Function:
Required for kinesin-mediated axonal transport of mitochondria to nerve terminals. The oocyte acquires the majority of its mitochondria by competitive bidirectional transport along microtubules mediated by the Milton adapter. Mitochondria enter the young oocyte en mass from interconnected germ cells to generate the large aggregate known as the Balbiani body. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria.
Miscellaneous:
MISCELLANEOUS: Was named 'Milton' after the blind British poet.
Subcellular Localization:
Mitochondrion.
Sequence:
MTHVNNGEVMEKEMEPTGERERDRETAAGSGVHHRFLASASERDANSGNALEAAATKTKTGTTITNLEDLAFEACQNWSDLHQDFFITDDELEYEDELSLGSSIGGNIATTTTADAAVEGLITGEHQNEQLLMEVLCGNRVSQMTRAYDDIEAVTRLLEEKEKDLELTVQIGKELLTQNNALEARVADLETDLKASNDDRAQLVHELHKKNELISVLTNDADDGTDTDTPTMSKSITLDLLQRKVNSLLDENKSLKCEATQLAHQTDEVEEHERQLMADISAQLNDANSQYDNLSLELERQREENRLQHEQIVNLTARLAEAEMRLHQLTQDNDEHLSLLHVTKENQNALALELVEFKQRYEEVLALLHSAQDQLKQQRKRSQPQARSSFLGGLGTSGAGMGGSLFPPDSLHCELMESSLYSENSLDSGISGDSQRSADRISRMMMHMPSGGMSSSTMGGSVYAGAGNVPPYKRVFDTVRCAGKSGNYMDSGNVSMTQLGAMSMSSSSGPRMASMAYPAGSYYRGGSNQSLGVKTLSSESLNSQSDDGYPAQPSGVPGAPGAKELEAALKRLTPAEVLARRAMLSYAPAGTYNYDEPMGHGTGNVRNSDLPLGVRTPDSIMSTGSSGMSGSTNHMSASMTHQWRLPEKLQIIKPMEGSQTLHHWSRLATPTLSGLLDERPGVTIRGGRGLDDLGMQIYTLSDVEEDVSDDLPGKQFEAPGCTFTYTNSMVMHPDDGFVNDLSFLSQSQMSSRMASTSTSRQPSCPATPRAGLSRKNSCSTFSVNLGLAGMLNERGIKAVTPSALNTPAGPNFSPTVTPCNSPEGSPPRAQSPEPLFGLLSCGADLIRRKIVGDQHQQQQQKQRSSLSKQQQQKIMLSHLERRALRSLNLIEKVESIGLENIISAQRGLGSGIANRSSSPLSSGSLQSLHTSSNSIVDDIHFDRAQIKGVLHRGLKSPTPATASTSAAAAASGPGISTSSSTSAYNSDDSDDQGLVMKIKPSKSATPTTTGAAQSQPSSATTSNGTASETRLKQMQRQKSRRQLKNGMANQRPDLGTISGAGGGGRVRPDLGKVADSGSSSKLSTKRSEAKPAEEEEATPQTITQAFVGSVSSLLFGRKGGWL
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Subcellular Localization:
Nucleus.
Domain:
Both the JmjC domain and the JmjN domain are required for enzymatic activity. However ARID and PHD-type 1 domain are not required for activity per se but contributed to recognition of the H3(1-21)K4me2 substrate peptide; The 2 first PHD-type zinc finger domains are required for transcription repression activity.
Sequence:
MEPATTLPPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTSDTKDKEYKPHDIPQRQSVQPAETCPPARRAKRMRAEAMNIKIEPEEATEARTHNLRRRMGCTTPKWENEKEMKSTIKQEPTEKKDCELESEKEKPKSRAKKTATAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLVPPLHDVPKGDWRCPKCLAQECNKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKISPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCIKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYNLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQQSQKLLSEEMPSAAELQELLDVSFEFDVELPQLTEMRIRLEQARWLEEVQQACLDSSSLSLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLRARPRHSLSSLATAVKEMEEIPAYLPNGTVLKDSVQRARDWVQDVDALQAGGRVPVLETLIELVARGRSIPVHLNSLPRLEMLVAEVHAWKECAAKTFLPENSTYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPSGKKRSTKLESLSDLERALMESKETAAAMATLGEARLREMEALQSLRFANEEKLLSPVQDLEMKVCLCQKTPATPMIQCELCRDAFHTSCVAAPSISQSSRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKLVQDQVGSGLLSSRWPASAGQASATDKVSQPPGTTSFSLPDDWDNRTSYLHSPFSTGQSCLPLHGLSPEVNELLMEAQLLQVSLPEIQELYQTLLTKPSSVQQADRSSPVRSSSEKNDCLRGKRDAINSPERKLKRRPEREGLPSERWDRVKHMRTPQKKKIKLSHPKDMDSFKLERERSYDLVRNAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTGKDAPSRK
The following text describes a protein:
Function:
May play an important regulatory role in corticotrophs.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle lumen. Note=Found in the lumen of secretory vesicles (dense core vesicles, DCV). However, seems to be retained intracellularly and not secreted (By similarity).
Sequence:
MQSSLKPAGSGVLQLLVCFLLLYSRPSSCSDINAHDGQGQVGSEQLWTFQGLVASVFQYLQLLFHHIVPQGMFWTDDIAYELMTKKVEHLSRLHPQYPCRKEGKVVSPIATTGVRGKQEEKLRLLSPQKSPAVKVNRDRCFTTKVIPKATKQEVTHPSKGFFGPFPTVGLNLVAD
The following text describes a protein:
Function:
Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms. Also cleaves, in vitro, inactive caspase csp-2 isoform b. Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 canonical apoptosis pathway. Involved in the degeneration of dopaminergic CEP neurons in response to high Mn(2+) levels; [Isoform a]: Dispensable for regulating apoptosis during embryogenesis.
Sequence:
MVLKTIEDNCKSQFDDDLVEDFNNFQTTSSMSSSTTISTEDFNTIEIESTFEICRSGSYTEEPILGENDEFLIDFEMERFLKFLKDKTKQVEKRKEPFSQKEIYAVFQRRIKSELCIETVKKKFQPLLPNAIQTCEFDEETMIRMIYGAGIRIDSVDFWNRFTSKATISLDCYSRLISYSSDSLTLSGTHRSGFTYHWISTPPVTYHRTENKDPNIQEPSPVEFLDVQSSLGSSMKPPILDKPTKLDDPAETRHDCSYSLEEYDSQSRMPRTDAKKSNHKHKYCYEMNSNPRGTVLILSNENFKNMERRVGTKQDEVNLTKLFQKLQYTVICKRNLEAESMLEAIKEFAEMAHTDSIILFLLSHGDGAGSVFGIDDMPVNVMEVSTYLAYHQNLLLKPKWVAVSACRGGKLNMGVPVDGLPALEDKCAPISKFWNLMMSRIMPGTFTSLNADVIISFSTTDGFTSYRDEEAGTWYIKSMCKVFNKHSKTMHLLDILTETGRNVVTKYENVQGNVVLKQAPEILSRLTKQWHFSRSM
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MEDDKRLDLSLSLPCGRPSAASKGKTVIGSDVRVEEADNRGSKLIDDFKNFLDGSNHKEESTIVSQRIQQSKPEENIVYDLSKGPSNTETGNKRKNMFDEINNQKRHERDNYLATLHIKPRTPHVSITADDASAAENEDVADSEAGDVSKRSESTGVDLQSQRAFTISSEKELKVGHVVSHGGVFPGQSANVMNLPYSLSVKESNSIPGSQQPVIPANLPLMFGYTPVQVATVTPAGVTPVNTPKPFDRAKGDNKRAKEDGPSMHTEVDMKGTNVIDQSQPERFPQEYPAIRPGIAAELKFGGSGSSPNLPWVSTTGPGPNGKTISGVTYKYSGTEIRIVCACHGSHMSPEEFVQHATEEQPNLNGARAGGGAGLPPFSSSNPAASAQN
The following text describes a protein:
Function:
Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds. Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Membrane raft. Note=Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KCNQ1 (By similarity).
Sequence:
MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKAVFQARVLESFRACYVIENQAAVEQPATHLPELKPLS
The following text describes a protein:
Function:
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
Sequence:
MNPFSSGTRLRDMIRAIRASKTAAEERAVVRKECAAIRAAISDNDHDYRHRNLAKLMFIHMLGYPTHFGQMECLKLIASPGFPEKRIGYLGLMLLLDERQEVLMLVTNSIKQDLNHTNQYIVGLALCALGNIGSAEMARDLAPEVERLLKFRDPNIRKKAALCSIRIIKKVPDLAENFIHAAASLLSEKHHGVLITGVQLCIDLCKISTEALEHFRKKCTDGLVKLMRDLANSPYAPEYDISGITDPFLQIRLLRLLRSLGKDDADASDTMNDILAQVATKTESNKNAGNAILYECVAAIMSVEDNGGLRVLAINILGRFLSNRDNNIRYVALNMLMKALAVDSQAVQRHRTTILECVKDSDPSIRKRAVELVYLLVNESNVKPMTKELIEYLEASDPEFRGDLTAKICSIVEKFSPEKIWYIDQMLKVLSEAGNDVKDEAWHSLIVVITNASNLHGYAVRSLYRSVQAAGEQETLVRVAIWCIGEYGDMLVNNAGRLDIEEPLTVTESDAVDVLETSFKSHSFDLTTRAMCLIALLKLSSRFPTCSQRINDIIVQYKGSFVLELQQRAIEFNSIIARHQNIRPSLVERMPVLDEATHSGRKAGSVPAAVSTSQGVSVNLPNGVAKPSAAPLVDLLDLSSDDVPAPSSSGGDFLQDLLGVDLVPVSSQSGTNQAQVSGTNVLLDLLSIGTPSANSSPSTIQASPSNVDTKSPMDLLDRLSSPSAPSVQVSTTAGSSPMLDLLNGFPSSSPIAVTEGNGLAYPSIVAFESSSLKLTFNFSKQPENPQTTLIEASFTNKSGEVLTNFIFQAAVPKFLQLHLDPASGNMLPANSSGSIMQKLKLTNSQHGKKSLVMRIRIAYKVNNKDVLEEGQVNNFPREL
The following text describes a protein:
Function:
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism. Also involved in telomere maintenance.
Miscellaneous:
MISCELLANEOUS: Present with 4220 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MWKIMRSWKCGGMRWAHRQRPSHELLSQLSFDQHYKIRSNIELLIQDYASKPIAPLNYEYFLQYRPPLTKKEEYMLTIKTINLLLSLTCKRLNAIQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYELHNPPKIQAKFTELLDDHEDAIVVLAKGLQEIQSCYPKFQISQFLNFHLKERITMKLLVTHYLSLMAQNKGDTNKRMIGILHRDLPIAQLIKHVSDYVNDICFVKFNTQRTPVLIHPPSQDITFTCIPPILEYIMTEVFKNAFEAQIALGKEHMPIEINLLKPDDDELYLRIRDHGGGITPEVEALMFNYSYSTHTQQSADSESTDLPGEQINNVSGMGFGLPMCKTYLELFGGKIDVQSLLGWGTDVYIKLKGPSKTALLSKK
The following text describes a protein:
Function:
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Sequence:
NDHKMSSVTTRQSSYKRMFGGERSIAPSTSFSSRRYSSPIRSRVSYSMSAPPAIYATNTSRLRSSATMPRLSTETSDFSLSDAVITDFKASKSNEMAEMQHLNDRFVSYIEKVCFLEQQNKILLAELEQLQGKGISRVGDLYKEEMRELRGQVDQLTTDKARVEVMRDNLDDDLQRLREKIQDEMRLREEAENNLQSFRQDVDHASLARLDLERKVESLQEEIAFLKKLHDEEVAELQAQIRHQHVQIDMDVVKPDLTVALRDVRTQYESLASKNIAEVEEWYKSKFADLTEAAARNNEALLQAKQESTEYRRQVQALTCEVHALKGTNESLEHQMHEVEENFALESSRSQDTIAHLEVDIRNMKDEMARHLRDYQDLLNIKMALDMEIATYRKLLEGEETRIATPGPMFSSLNLRGKQNLPNSEEDQNMNHAKQTFISLTRGSRVMQVIKEATQHHDELE
The following text describes a protein:
Function:
May function as part of axonemal radial spoke complexes. Radial spoke complexes are important for ciliary motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium. Cell projection, cilium, flagellum.
Sequence:
MARGDNMKSSNKSTPEPTLSKTLVESSTSSLLSESVVEPEDGQDLSSSAVCSASTVSLPPNENQPIGEHDRCRTVPVLHSIIVERYEGEKCGEMFHGEGVAYFQGGHVYKGSFSHGLMHGYGEYIWSDGLKYQGDFKVNVPMGHGTYTWLNGSTYEGEVHQGIRHGVGMYKCVKTLTVYRGQWYLGKRQGQGEMFYNQEATSWYKGEWVNNCREGWGKRCYPSGNVYEGQWRNNVRHGEGTMRWIDLDQQYSGQWINGIQEGKGTHTWFRKRAPSSQYPRMNEYTGDFVQAMRHGQGQFLYASGALYCGQWKYDKKHGQGRYIFENGRVYEGEFSKDCMAEFPAFTPGLSGITTPFPDENDSSKGASQSSSNASPLGSDMVLNIQTLLNRVSEAHREQEFKQVEFAVLRHMGLLREIYSFYSSLGHEQSLDKIFPLTHLQFSRFLLDCRVHQHGVTLAQIYSLINVHSPFTAILPRECISYIIIIAYHICHKDIESSNNILAACFSKLMKQNIIPNAKSVKGHLFCHPVHAAVAMNYSDKSWEIYQALCEAHSVFTVRQFVLMLKDLCLYDNELTVSKLIRTLSVDSPAIHDGTYSNLDLEMSFLEFFEALLGCAELKGQKIQSYDESQTDASLQDHISSLSKEKEQRQSPVLAYQETELNDWMHKTQQFFNQTFLPAYELKVKVEEETFRLRDNTTTRYTEQLELKEKQEQDADGNELCPVTTTSVTSIH
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MIAPATVKLMQFGGLGIWEILLLVLIALILFGPRKLPELARAMGEAVREFRKAASSTEESQKSSSQSERTEGKSSIRELAISLGIDVSGKTDEEILEEIKSRIRSNSS