lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MEEIRELVLKYALINAYTHRGKANPKAVIGKVLGENPELRKRAKEIIPLVNEVVNEVNSLSLEEQEAKLREIYPEFFEEKNEKKEEKKGLPPLPKAERGKVVTRFAPNPDGAFHLGNARAAILSHEYARMYDGKFILRFDDTDPKVKRPEPIFYEWIKEDLEWLGFRIDEIHIASDRLEIYYDYAEKLIKMGKAYVCTCPPEKFRELRDKGIACPHREEPVEVQLERWRKMLNGEYREGEAVVRIKTDLNHPNPAVRDWPALRIIDNPNHPRTGNKYRVWPLYNFASAIDDHELGVTHIFRGQEHAENETRQRYVYEYFGWEYPVTVHHGRLSIEGVILSKSKTRKGIEEGKYLGWDDPRLGTIRALRRRGIKPEAIRELIIEVGLKRSDTTISWDNLAAINRKIIEPIANRYFFVADPIPMYVEGAQEFTAEIPLHPDYPERGVRRLKFEPDKPVYVSKDDMELFKPGNFVRLKDLFNVEIMEVNENGIRARFHSFEYEVARENRWRMVHWVTEGKACEVWVPEGDELIIREGLLESDADVKVDDIVQFERFGFVRIDDVRPEKVVAIFAHK
The following text describes a protein:
Function:
Extracellular signaling peptide that may regulate primary root growth rate and systemic nitrogen (N)-demand signaling (By similarity). Mediates up-regulation of genes involved in N uptake and assimilation pathways.
Subcellular Localization:
[C-terminally encoded peptide 8]: Secreted, extracellular space, apoplast. Note=Accumulates in xylem sap.
Sequence:
MAKALFFNFCISLLIIAILVSHEIIPTEARHLRTHRKSIKNSTLTVHEGAGGLRTGGGSVKTDISKEEHGVDEFRPTTPGNSPGIGH
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MITDVQLAIFSNVLGVFLFLLVVAYHYINANTGKSIIKSK
The following text describes a protein:
Function:
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
Subcellular Localization:
Periplasm.
Sequence:
MKVNLVHFFRIFVLFISTAANAETVVPSVSAISELAKALINEKISVPANAKVDINPQTVDQRMLPAQCASPIKVELASDREIRRNNTVKVSCNTPDLAYPWQIFISVRVDILFPVVVATEPLAPGELISPTQVEIRYVDQNSLRGMQFSDINQLSGVRVKRRVAKNNPIFANNLCFVCKNDAVSIYVRSSNFVLKTVGEALQDGNIGDQIRVKNSSSNKELDATVTAIGEVEVRM
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MTSSQLETAPLPADDITIADAIKASCEKCLDNYSISINKTACEQFFLNLDRKDYEKRVDAEPANLKFPLQFSSQLDELNVVAMVCLLEGFHSYEDLLKEKTGRGVWETMRYLVLAAYLSPESQSTSILTTRGMIEATPEYISTTLSLPLHIERPIAENSPISLAEPDRPVTRFVEDLLSLLHSTGKILQQSGLPNLASFLATRSNLNDDEMIRQLAAAFSPFRDMYTIDGKNVYLMQKVLFLIHKIQNTPISFPKLKSPRPILADNILPVFLVQAGLLDISKSTDSSLRNLNLSDSHLKISSRSATILRASSVACCQFLIDLVQGLSQTNKSLEYVEQDGLVRYLSNLSRERSSSCAFREEETVVY
The following text describes a protein:
Function:
Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation; [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR; [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR. Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy.
Subcellular Localization:
[DAP3-binding cell death enhancer 1]: Mitochondrion. Mitochondrion outer membrane. Mitochondrion inner membrane. Note=Imported in the mitochondrial matrix in absence of stress, leading to its degradation by LONP1. Localizes at the mitochondrial surface in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting localization at the mitochondrial surface and stabilization. Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1); [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol. Note=This short form is generated by proteolytic processing by OMA1 in response to mitochondrial stress, leading to translocation to the cytosol.
Domain:
The TPR repeats bind to and activate EIF2AK1/HRI.
Sequence:
MWRLPGLLGRALPRTLGPSLWRVTPKSTSPDGPQTTSSTLLVPVPNLDRSGPHGPGTSGGPRSHGWKDAFQWMSSRVSPNTLWDAISWGTLAVLALQLARQIHFQASLPAGPQRVEHCSWHSPLDRFFSSPLWHPCSSLRQHILPSPDGPAPRHTGLREPRLGQEEASAQPRNFSHNSLRGARPQDPSEEGPGDFGFLHASSSIESEAKPAQPQPTGEKEQDKSKTLSLEEAVTSIQQLFQLSVSIAFNFLGTENMKSGDHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLLRDPASSWNPERQRAVSLLKQAADSGLREAQAFLGVLFTKEPYLDEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALRCYQQSAALGNEAAQERLRALFSMGAAAPGPSDLTVTGLKSFSSPSLCSLNTLLAGTSRLPHASSTGNLGLLCRSGHLGASLEASSRAIPPHPYPLERSVVRLGFG
The following text describes a protein:
Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.
Sequence:
MRPEVEQELAHTLLLELLAYQFASPVRWIETQDVILSPPVSAERIVEIGPSPTLAGMAKRTLKLKYENMDAALSINREVLCYSKDAREIYYNFEDEVADEPAEAPASTSSTPKVETAAAAAPAATPAPAPAQTSAPAAALPDEPPKALEVLHTLVAQKLKKSIEEVSPQKSIKDLVGGKSTLQNEILGDLQKEFGATPEKPEEVPLDELGAIMQSSFNGSLGKQSSSLISRMISSKMPGGFNNSAVRGYLGNRYGLGPGRLESVLLLALTMEPASRLGSEADAKAWLDSVAQKYAARNGVTLSSPTAEGGSSSGSAAVIDEETFKKLTKNNTMLVTQQLELFARYLNKDLRAGQKAQVAEKVISDTLRAQLDLWNEEHGEFYASGIAPIFSPLKARVYDSDWNWARQDALKMFFDIIFGRLKHVDTEIVARCISVMNRSNPTLLEFMQYHIDHCPAEKGETYQLAKTLGQQLIDNCKSVIDAPPVFKNVNHPTAPSTTIDERGNLNYEEIPRPGVRKLTHYVTEMAKGGKLPTESKNKAKVQNDLARIYRIIKSQNKMSRSSKLQIKQLYGQVLHALSLPLPSSNDEQTPVKETIPFLHIRKKSVDGNWEFNKSLTGTYLDVLESGAKNGITYQDKYALVTGAGAGSIGAQIVEGLLAGGAKVVVTTSRFSRKVTEFYQSLYTRHGSRGSCLIVVPFNQGSKTDVEALIDYIYDEKKGLGWNLDYIVPFAAIPENGREIDGIDSRSEFAHRIMLTNILRLLGAVKSQKASRGMDTRPAQVILPLSPNHGTFGNDGLYSESKLGLETLFNRWYSESWANYLTICGAVIGWTRGTGLMAPNNIVSQGIEKYGVRTFSQSEMAFNILGLMSQKVVDLCQSEPIYANLNGGLELLPDLKDLSTRLRTELLETAEIRRAVAAETAFDHSITNGPDSEAVFQKTAIQPRANLKFNFPKLKPYEALSHLSDLRGMVDLEKVPVVTGFSEVGPWGNSRTRWDMECYGEFSLEGCVEIAWIMGLIKNFNGKGKDGKPYSGWVDTKTGEPVDDKDVKAKYEKYILEHCGIRIIEAELFHGYNPEKKELLQEVVIDHDLEPFEASKEAAHEFKLRHGDQVEIFEIPDSTEWSVRFKRGTSMLIPKALRFDRFVAGQIPLGWDPKRYGIPDDIISQVDPTTLYVLVSTVEALVASGITDPYECYKYIHVSELGNTVGSGIGGMSALRGMYKDRWTDKPVQKDILQESFINTANAWINMLLLSASGPIKTPVGACATAVESVDAAVDLITSGKARICISGGYDDFSEEGSYEFANMGATSNAAKETERGRTPQEMSRPATSTRDGFMESQGAGVQIIMQAKLAIEMGVPIHGIVGYVSTAMDKQGRSVPAPGQGILTGAREIATKTPLPIVDLKFRSRQLQRRRSQIGEWAEREYLYLEEELDAMKVQNPDLDLEAYRIERINVIKEEVVRQEKEALNTFGNEFWKRDPTIAPIRGALAVWGLTIDDLGVASFHGTSTKANEKNECDVIDSQLTHLGRSKGNAVYGVFQKYLTGHSKGGAGAWMLNGALQILRSGFVPGNRNADNIDEYLARFDRVMFPSEGIQTDGIKAASVTAFGFGQVGGQVIVIHPDYIYGVIDEATYNAYKAKTAARYKASYRYTHDALVYNNLVRAKDSPPYTKEQEKAVYLNPLARASKSKAGTWTFPATLPAESDISKTNETTRTLQSLTTSLTNSNENVGVDVELVSAISIDNETFIERNFTDTERKYCFAAPNPQASFAGRWSAKEAVFKSLGISGKGAAAPLKDIEIISSESGAPEVVLHGEAAKAATTAGVKSVSVSISHDDNQSVSVALAHK
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGDEYQVVVVAGGSSKDLFPLVSKDVPKALLPIGNRPLLSYVLDLLEDSNLNNVSVVVAGHESGVRVGSWIAEAYHDRLQVEVSTVSEESGTADALRSVAHRLSSENVMVVSGDMVCDVPLGAIASSHKRQRAGLTALLCPRTPGEGCEASAGGVGTKEKAKQLAAADVIGLDSARHRLLYVASGSQLGKEVKVPLCLMREAGQVELHTDLLDAHLYAFNRELMLEALERNEKFKSIKRDLVPHIVRSQLKHGRVEGTLSCSAYVAGKARYCARVNTIEAYGDINRDVAGDAIYLTGYTVSGMNNVIHPSAQTGAKTAIGPQCIIGEGSELGEKCSVKRSVVGRHCRIGSNVKVINSVVMNHVTLEDGCLVQNSVICSNVHLQERVTLKDCQVGCGYVIGVGAEHRSEALAKKEKSWGLNANE
The following text describes a protein:
Function:
Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain.
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Synapse, synaptosome.
Sequence:
MEPSPTAGGSETTRLVSPRDRGGIGGGLRLKSLFTEASEPVPEEPKPTEMSFQHCHKDPLPQPGLTPERLQAQRQLCAACAVCCVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFIRLLHSDYHIEGGAMLLTASIAVCANLLMAFVLHQAGPPHSHGSRGQSMHRWRRGLGRPCPWGTPASGRPLCMCWGTSCRALGCWLPPSSSTSSLNTRQLTPSAPSSSPSAPSDPPLPPSETFSASSWKVPPEVWGSSLCEIPCCQCQESGQPMSCTCGPSRSPTTLPLHTWPSTPQLTPKLSWLKPHPGSTPGLDSPAVPCRSSSTSLRWPSACAAGSPPKPEPRPHLPPPTARPLAQPWTLSTCLPAHGEVAELGLHPSSLPASTCRPPSPSGQDQSVCGAWARSQAEQGTQSSGGV
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRTGYCGSLTTFSSWILQVVVLMVGRTAAGASGAAEGTQWVEALWAIYVGVSGPLVALVVGQQAGMAVAHALARREVAVAGQPAAAAAADAGPAAKTDGEASTLPHQPPQQSGQPDGRQQPQPGSRPVAEATAAEEALLPPAASQGQLAAAADASADGGCVTVTVQSAAVAEATEPTATTTATNTINNHSNNNIGNANNTSNGNAIVLPTGAGAMAAAANAAEPRLPLTAPPPAPPAVAPQPQPLLLPHLAADVAALLALLTLTGVSAAYAHQDREPAGNPRRMWWIAILLGPPGAVLRWYLSRFNAVPASWRGCSRGCGLGFGGSSSCGGSGSGSSGSGKVGGGEGSWAWLQLGTFVANLAACCLNFTAEAILFRQGGSMTDLQAVVLQALMTGTAGCLSTVSTWVVELQKLSAASPNGAGAAAYKYGAVSVITPVVLGLLAYGVPAWTAPRP
The following text describes a protein:
Function:
Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MKYILFATAGHVDHGKTTLIKTLTGIDTDRLPEEKKRGLSIDIGFAYIDFPDINTRLEIIDVPGHERFIKNAIAGICSASGLILVVDPNEGIMPQTIEHLRVAKSFGIKHGIAVLTKMDKVDEELAHIAEEELIAFLEKEEMNMEIVKVSAVTGQGIEDLKNSIKKLLESINNLNKHKPLRIFVDSAFVVKGYGTVLRGSCFEGEVKEGDKVVVEPIGVISRVRKMQNHGVFVKKAVAGERIALNLPEVDAKKVKRGFLILKPESYEKSNVLIVKTEIDLKPGKIYQVFFGMRETVGKISVIDKGIYLVRLKENAIVRRGDKLVVLDSSGNFLGGAEVLHPKVRVTKKAFIKKNIKDLLENFECYLLKERGPIGLKLEFFKRITGVSPKVANLKPESIEIRGVYYLKGFIENLKLKIKKFLDTELQNAFGVDKEKVKSMFSLNEELLKYILDELKTYKIVNELIIDERKSDLEKNEDFQKLMSILKGGIKEEREIILEGIPKEILTLSIKRKYAHRIGEYLIISDELLKKYINELKELGKTFNVQQAKNKLGLTRKYLIPLLEYLDYLGLTVREGNERRWKR
The following text describes a protein:
Function:
A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.
Sequence:
MALYGYARVSTSDQDLTLQTQILRAAGCEIIRAEKASGSGRTGRSELQLLLEFLRPGDTLMVTRVDRLARSIKDLQDIVYALNQQGVTLRATEQPVDTRSAAGKAFLDMLGVFAEFETNLRRERQMEGIAAAKARGVYRGRKPSIDPAVVYRLYTIEKMGATAIARQLGIGRASVYRALENYEQPA
The following text describes a protein:
Function:
Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling (By similarity). Involved in adventitious (crown) root initiation under the regulation of CRL5.
Miscellaneous:
MISCELLANEOUS: Crl5 mutant plants overexpressing RR1 display significantly increased adventitious (crown) root formation compared with crl5 mutant plants.
Sequence:
MEGGRGVTRVLLVDDSPVDRRVVQLLLSSSACAGSFHVIAVDSAKKAMEFLGLKEEGKEQAIDMVLTDYCMPEMTGYELLKAIKALSPLKPIPVIVMSSENEPQRISRCMNAGAEDFIVKPLQSKDVQRLRNCSPANTQCCDAGSDGKPPLLLLPSDHVVVDATAASPPPPPSRRRAHFAGVAMVLHSSSVELSHYFPFLFKFILLVYAILCLGELLHRWSNGCFLNLWCA
The following text describes a protein:
Function:
Promotes cell adhesion and matrix assembly.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Note=Isoform 2: Cytoplasm.
Sequence:
MTWKMGPHFTMLLAMWLVCGSASQSSALDSDGRPGRKVPLASPISSRSARYLRHTGRSGGVEKSTQEEPNPQSFQRRKSVPVLRLAHPTVRPPPSGINGAPVRPELKPIARGSASEMVRDEGSSARTRMLRFPSGSSSPNILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPNLIPKLMSFLKLEKGKFSMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKGFVQKCKASGIEGHVVQEGNNGGGGGGSTGLGSDKRKEDPRRTQIHPTREPPRKQTTTKAATPQPPPTPRATTLPPAPVTTATRATSRVVTVAARPTTTTAYPATQRPWTSRLHPFSVSHRPPATAEMTTVRGPSVSEQLYPLPRKEQQREKPQATRRPNKATNYGSFTATPPTTLWEGSTRAVGTSRFRDNRTDKREHGHQDPNVVPGPHKPIKGKLPKKKEKILSNEYEAKYDLSRPTTSQGEEELQVDNIPSQNAKESKKHEKPEKPEKEKKKKGKSAKPDKLLRSEKQMKKAEKKSKQEKEKTKKKKAGKTEQDDYQKPTAKHLAPSPRKSVADLLGSFEGKRRLLLITTPKAENNMYVQQRDEYLESFCKMATRRISVVTIFGPVNNSSMKIDHFQLDNEKPMRVVDDEDLVDQHLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPIAMKSVFDLIDTFQSRIKDMEKQKKEGITCKEDKRQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQLSALNGQACNFGLRHITILKLLGVGEEVGGILELFPINGSSTVEREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRCPEDEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY
The following text describes a protein:
Function:
Catalyzes the transfer of the phosphate group from adenosine triphosphate (ATP) to (R)-glycerate to form (2R)-2-phosphoglycerate, an enzymatic step in (L)-glucarate/galactarate catabolic pathway.
Miscellaneous:
MISCELLANEOUS: GK1 has a half-life of 92 minutes while GK2 has a half-life of 11 minutes at 49 degrees Celsius.
Sequence:
MKIVIAPDSYKESLSASEVAQAIEKGFREIFPDAQYVSVPVADGGEGTVEAMIAATQGAERHAWVTGPLGEKVNASWGISGDGKTAFIEMAAASGLELVPAEKRDPLVTTSRGTGELILQALESGATNIIIGIGGSATNDGGAGMVQALGAKLCDANGNEIGFGGGSLNTLNDIDISGLDPRLKDCVIRVACDVTNPLVGDNGASRIFGPQKGASEAMIVELDNNLSHYAEVIKKALHVDVKDVPGAGAAGGMGAALMAFLGAELKSGIEIVTTALNLEEHIHDCTLVITGEGRIDSQSIHGKVPIGVANVAKKYHKPVIGIAGSLTDDVGVVHQHGIDAVFSVLTSIGTLDEAFRGAYDNICRASRNIAATLAIGMRNAG
The following text describes a protein:
Function:
Regulates the expression of the alsSD operon for acetoin biosynthesis.
Sequence:
MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVGVTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSATYEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETAQSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPNIVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDNHNPLIKHFIHISNCQQTRTKESDAGT
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGQSIRRFTTSVVRRSHCEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLKT
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MTATPETATNRGVQRLHAAFARAEAEGRAAFIPFMTGGYPDAARFGEVAGDLLARADIMEVGIPYSDPLGDGPTIQRASEQALAGGTSTRRTLELVRELRQKDDTPIVIMTYINPIYAVGPAEFMRLAQEAGVDGLILPDLPPDQDLEIADLAAQHGLAVTFLIAPTSTPERVKLVAEACTGFLYAVSVTGVTGAREGAALGEVPRMLDLARQYAQRPVVVGFGVKDAATAQQVAQVADGVVVGSAFINAVAAGRDVGALADELAAGCRR
The following text describes a protein:
Function:
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAGQMPPWLQEQLMKLQQSQQNLQSIMTQKQHLEMEKAETEKALEELKKVGDADAVYKQAGTVLLKSTKKELVDELEEKQEMAKTRATVLEKQETRVKETLKEQESKITEMMKSGSQEPPKAEDNPRK
The following text describes a protein:
Function:
Transcription factor required for the transition to flowering promoted by FT.
Subcellular Localization:
Nucleus.
Sequence:
MLSSAKHQRNHRLSATNKNQTLTKVSSISSSSPSSSSSSSSTSSSSPLPSQDSQAQKRSLVTMEEVWNDINLASIHHLNRHSPHPQHNHEPRFRGQNHHNQNPNSIFQDFLKGSLNQEPAPTSQTTGSAPNGDSTTVTVLYSSPFPPPATVLSLNSGAGFEFLDNQDPLVTSNSNLHTHHHLSNAHAFNTSFEALVPSSSFGKKRGQDSNEGSGNRRHKRMIKNRESAARSRARKQAYTNELELEVAHLQAENARLKRQQDQLKMAAAIQQPKKNTLQRSSTAPF
The following text describes a protein:
Function:
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor.
Miscellaneous:
MISCELLANEOUS: The MCR reaction has been shown to follow an ordered bi-bi ternary complex mechanism, in which methyl-SCoM must enter the MCR active site prior to CoB for a productive catalysis.
Subcellular Localization:
Cytoplasm. Note=Under growth limiting conditions on nickel-depleted media, a fraction of 70% of the enzyme is localized close to the cytoplasmic membrane, which implies 'facultative' membrane association of the enzyme.
Sequence:
MAQYYPGTTKVAQNRRNFCNPEYELEKLREISDEDVVKILGHRAPGEEYPSVHPPLEEMDEPEDAIREMVEPIDGAKAGDRVRYIQFTDSMYFAPAQPYVRSRAYLCRYRGADAGTLSGRQIIETRERDLEKISKELLETEFFDPARSGVRGKSVHGHSLRLDEDGMMFDMLRRQIYNKDTGRVEMVKNQIGDELDEPVDLGEPLDEETLMEKTTIYRVDGEAYRDDVEAVEIMQRIHVLRSQGGFNLE
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MNDDDEEFHCRDIKNDSKDDNSDSYEDEDEDEEPFKKPTDQKTDSEVIAKEDDKIELSKIKESRYNSKVEDDNTDDEEEERGYQEKEKQPQESEQGDREYGHSKPHDDYSEDEREESTHDEDETEEEGFIPDPQTHVVTFIYEDDLTEPVLLKDNIFERAKDSLHLDAIPDKLPGREGEKAHIQAFLEPKINLGESGGTLYIAGMPGTGKTATVKEIIKNLQVKRKKSAIKLFRFIEINCMQLSYPDQLYQTLYSKLQFGRRSARPKTSEEALRLLKKRFNSNSAKKDFVIVLVDEFDCLLTKKEQTVIYNLFEWPNKPASKFVVIAISNTMNLPDQLSSRVKSRMGLQRLPFQPYNTQQLESIIKYRLGGLEAFDQDSIQLVAKRVATVCGDARRALEICRKAATIALQQNELDNLVQKVTDTHIDEVFKQFSLPIRRKLNQLSLFEKLFLYCVCKESKRINSLEVVYGAVYRKLQETTLSKGMYCPTESEILQLAGSLGGYKLILFEDDKPINWDHLLKLNISQVDLFYGLEEDEDLQTII
The following text describes a protein:
Function:
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Miscellaneous:
MISCELLANEOUS: The name KL-6 was originally that of a murine monoclonal antibody reacting with pulmonary adenocarcinoma cell lines and pulmonary epithelial cells. This antibody recognizes a sialylated carbohydrate chain on MUC1; MISCELLANEOUS: [Isoform Y-LSP]: Lacks the mucin repeats; MISCELLANEOUS: [Isoform ZD]: Lacks the mucin repeats. Exists as a disulfide-linked oligomer.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions; [Isoform 5]: Secreted; [Isoform Y]: Secreted; [Isoform 9]: Secreted; [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.
Sequence:
MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAVSMTSSVLSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTSAPDNKPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGSTAPPVHNVTSASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDASSTHHSSVPPLTSSNHSTSPQLSTGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVSVSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPARDTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL