lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MKRVIMENIKEKFEFEVNSEYEGMRLDKYLSEQIEEATRSYLEKLIDNNFVKVNSKIINKNGRKLKLGEKIEVLIPEEENIDIEPENIPLNIVYENDDFILINKSYGMVVHPAYGNYTGTLVNALLYYTNNLSSVNGNIRPGIIHRLDKDTSGLILVAKNNYAHAKLASMFIDKTIHKTYLCIVKGNFSEENLSGRIENLIGRDSKDRKKMTIVKENGKIAISNYKVVEQVEGYSLVEVAIETGRTHQIRVHMKSINHVILGDSVYGTEDKNVKRQMLHAYKLEFLNPLDNKKYIFKGKLFDDFIEVAKRLKFNIEKYI
The following text describes a protein:
Function:
Isomerase that catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between EBP and 7-dehydrocholesterol reductase/DHCR7. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). The precise role of each component of this complex has not been described yet.
Miscellaneous:
MISCELLANEOUS: Binds to the phenylalkylamine calcium-ion antagonist emopamil, an anti-ischemic drug.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Cytoplasmic vesicle. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles.
Sequence:
MATTSTGPLHPYWPRHLRLDHFVPNDLSAWYIVTVLFTVFGALVVTMWLLSSRASVVPLGTWRRLSVCWFAVCAFVHLVIEGWFVLYQKAILGDQAFLSQLWKEYAKGDSRYIIEDNFIICMESITVVLWGPLSLWAVIAFLRQHPSRYVLQFVISLGQIYGDLLYFLTEYRDGFQHGEMGHPIYFWFYFFFMNVLWLVIPGVLFFDSVKQFYGAQNALDTKVMKSKGK
The following text describes a protein:
Function:
Multi-solute ABC transporter that mediates uptake of unrelated hydrophilic compounds. Can transport vitamin B12 and related corrinoids, and antimicrobial peptides such as bleomycin. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Contributes to maintenance of chronic infections.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Contains a large occluded hydrophilic cavity that spans the entire thickness of the membrane and extends into the intracellular part of the protein. It consists of two connected chambers. The larger chamber is located in the transmembrane domain, and the smaller chamber is formed by the part of the protein that connects the NBDs and transmembrane domains.
Sequence:
MGPKLFKPSIDWSRAFPDSVYWVGKAWTISAICVLAILVLLRYLTPWGRQFWRITRAYFVGPNSVRVWLMLGVLLLSVVLAVRLNVLFSYQGNDMYTALQKAFEGIASGDGTVKRSGVRGFWMSIGVFSVMAVLHVTRVMADIYLTQRFIIAWRVWLTHHLTQDWLDGRAYYRDLFIDETIDNPDQRIQQDVDIFTAGAGGTPNAPSNGTASTLLFGAVQSIISVISFTAILWNLSGTLNIFGVSIPRAMFWTVLVYVFVATVISFIIGRPLIWLSFRNEKLNAAFRYALVRLRDAAEAVGFYRGERVEGTQLQRRFTPVIDNYRRYVRRSIAFNGWNLSVSQTIVPLPWVIQAPRLFAGQIDFGDVGQTATSFGNIHDSLSFFRNNYDAFASFRAAIIRLHGLVDANEKGRALPAVLTRPSDDESVELNDIEVRTPAGDRLIDPLDVRLDRGGSLVITGRSGAGKTTLLRSLAELWPYASGTLHRPGGENETMFLSQLPYVPLGTLRDVVCYPNSAAAIPDATLRDTLTKVALAPLCDRLDEERDWAKVLSPGEQQRVAFARILLTKPKAVFLDESTSALDTGLEFALYQLLRSELPDCIVISVSHRPALERLHENQLELLGGGQWRLAPVEAAPAEV
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MLDFIKGKVITVKPDKIVIQTGGIGYSVKIPIRVSRYINRDEETQIFTSLIVKEESIEIYGFLESSERDLFEELIKIAGIGPKMAINILSTYDRETLYKIIDHEDIKSLSKIPGIGKKTAQRILLELRGILPSLQYEKDQKYDDILSALLNLGYKRLEAKEVLDKIYNNEKDEATIIRESLSILAGKDGK
The following text describes a protein:
Function:
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MANVKKVCVIGAGVSGLSAIKSCLEEGFQPTCYEQHDDLGGIWYYTEDPRPNQGAAMFKSVVSNISKSMLSYSDFPFPEDAPMYPSHERVHQYLREYADHFNLLPHIRFGTQVIKVEEAKDHVTSGQWMVHTSGNGGKHETFDAVILSNGSAFGRPVSPDVPGYETFKGVKLHSYQYRTNKPFEGKRVLIVGSGNTAFDLAVDVCRVATQVDLALLKGTWVVPRLHKKGTPIDLHAFRRVYSDIPVSWLNGIFKDFSNNRFDHDKYGVAGRQQPITQSTPTINDDIGLCLASRKVSIKPQLVKLFGTSARFADGTTVGDVDAVIFATGYVNSCSFLDHELEADIKKLDLYKLVFPTRLAHPTLALVGAGQSNGPLFPLMELQARWAARVFKGVHKLPNSDTMKANTEVYKDMVLATFGRLKPVTNNVVYRDDIAAEIGAKPNLLWLIIKDPLLAYMYYFGPAYPFHHRLVGPNPWKGAAAASKHAYYNTLSGVATSFTPKDSGSVWLHTKMMFTCVIIGVICALVIITRL
The following text describes a protein:
Function:
Binds double-stranded RNA.
Sequence:
MQDVSTCYVFKSRLQEYAQKVGLPTPVYETTKEGPSHEPMFTSTVIVNNVRYESLPGFFNRKAAEQSAAEVALMRLVNSGSMENLSQPVVIYFILHHLRQNNCASALICTVILTVLYSNQKPQCQHETGLCKNLLQEYAQKMNFAIPKYECRRYDPEGKVITFSCTIDVGGMRYVGAAARTKKEAEIKAARTALLAIQSSSTGPNGYSAYTVLPMKKVTDLSISNQESAAALKPKKNRFKKKKKRNVCTRNTGDVQVQMVNQGTESPAPLAPTMGDPAPFNISSSVENRTALVVSQNDRGTSTLGINSQFGGAGTAEGNAVIGVEQVTSEVHSSTVVITWRNNSHVR
The following text describes a protein:
Function:
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
Subcellular Localization:
Secreted.
Sequence:
MPFLWLCWALWALSLVSLREALTGEQILGSLLQQLQLDQPPVLDKADVEGMVIPSHVRTQYVALLQHSHASRSRGKRFSQNLREVAGRFLVSETSTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPRTALRRQKRLSPHSARARVTIEWLRFRDDGSNRTALIDSRLVSIHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPGTWSSHKLVRFAAQGTPDGKGQGEPQLELHTLDLKDYGAQGNCDPEAPVTEGTRCCRQEMYLDLQGMKWAENWILEPPGFLTYECVGSCLQLPESLTSRWPFLGPRQCVASEMTSLPMIVSVKEGGRTRPQVVSLPNMRVQTCSCASDGALIPRRLQP
The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MQFQLTFFLHLGLLSYAKAQDECHRGACHPTTGNLLVGRGAQLTASSTCGLDGAQKYCILSYLEGEQKCFICDSRFPYDPYAQPNSHTIENVITSFEPDREKKWWQSENGLDHVSIRLDLEALFQFSHLILTFKTFRPAAMLVERSTDYGHTWKVLKYFSKDCAASFPNVTSGQAQGVGDLVCDSKYSDIEPSTGGEVVLKVLDPSFEIEDPYSPHIQDLVTLTNLRINFTKLHTLGDTLLGRRENDSLDKYYYALYEMVVRGSCFCNGHASECGPMQTVRGDVFSPPGMVHGRCVCQHNTDGPNCERCKDFFQDAPWRPAAGLQDSTCRACSCNGHSDRCHFNSTVYLASGGLSGGVCEDCQHNTEGQHCHRCRPLFYRDPLKAISDPYACIPCECDPDGTISGGICVSHSDPAVGSVAGQCLCKDNVQGAKCDQCQPNHYGLSAADPLGCQPCDCHPHGSLPLSPCDVDTGQCLCQPSATGPRCDECAVGYWGLENHLHGCSPCDCDIGGAYSNVCSPKDGQCECRPHITGRSCTEPAPGYFFAPLNFYLYEAEEAMPLQGLAPLGSATFGQVPADHGVFPEPVPGSPVTWTGPGFARVLPGAGLRFTVNNIPSAMDFAVAIRYETQSADDWAVQIMVNPPRGSKHCTRKTPWPKPQSFALPAASRIVLLPTPICLEPDVQYSIDVYFSQPLEGRSHAHSHILVDSLGLIPQINSLENFCSEQDLDEYQLHNCVEIASEARPRVLPSACERLIVSVSARLHEGAVACKCHPQGSVGPSCSRLGGQCQCKPHVAGRCCDRCSAGSYGLGHHGCHSCHCHPEGSKSIVCDQITGQCPCQGEVAGRRCDRCLAGYFGFPNCRPCLCNGFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQSCRPCPCPDVPSSNQYFAHSCYQNPWGSDVICDCLQGYTGKQCEECSAGFYGNPRISGAPCQPCACNNNIDLSDPDSCSRVTGECLRCLHNTHGPNCQLCKPGHFGSAINQTCRRCSCHPSGVNPAECRPDQGACLCDPDTGTCPCLPNVTGQACDHCADGYWNMIPGRGCQPCDCDPQTSHSRHCDQVTGQCLCKLGYDGKRCSECKENYYGDPQGRCIPCDCNQEGTQKPVCDQATGMCRCQEGVSGPRCDRCARGHNQEFPACLPCHSCFDQWDHTISSLSKAVQGLIRLAATMDDKRETLPACEADFKDLTENMSEIERILKHPVFSSGEFLKVKDYHDSVRKQIEQLSGQLKTVYEFQDLKETTERMRNEADLLLADLQEEIDLRSGARNASIVDSLESIKKYYQSSSYAEKETNETTLIISNSEKTRNDLLTNLDTLTSKGNLSREKLKQIKIPDIQILNEKVCGERGGAPCVVSACGDPRCHGSLTLSRDALQKAQEAESTTHNLSNQFQGLKNQIKNISKLAEVSKNNALQLSEKLRNMKNQSESEEEKLNLLIKKLKKFLLEENVPPEDIEKVANRVLDIRLPVTSQNLTHELDKIRKLTQLCEDYRADENRLNKAAEGARKVLVKAKGAKKAAHVLLNLDKMSNTLQQVRITQGRANSTITQLTAEITKLKKNVLQAENQAKETKNELHLAKQQSALEDGLSQLWTKLQRNRDQASRVKAQAESARRQAGGLEEEFVELKNQYAVLQRKTSATGLTKETVGKVKQLKDAAEKLAGDAEDKIRRITDLEKKIQDLNLSRQEKADQLKQLEDQVIAIKNEIVEQENKYATCYS
The following text describes a protein:
Function:
RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.
Subcellular Localization:
Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body.
Sequence:
FGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPRPDRLVNRLKNITLDDASAPRLMVLRQPRGPDNSMGFGAERKIRQAGVID
The following text describes a protein:
Function:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Localization:
Secreted.
Sequence:
MKLLVCYLLAITCVLVDADKGERILKLTEVIKELKALNRTVTHNSVMSNAPSMDTEECCSQSALKCFRAMVPHLKAKNKTLQRKVIKNLNNRMILGSLDSCSQEEREKTVCQGCDSYPKDSQKCVQQLESLLQKAISRLA
The following text describes a protein:
Function:
N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
QSWSSILYLERNRPQPTGTATALNSPCAETAWPAAASPGARGGAARQPGPGHHASPAGRAAGLRGWKSPSPTEQSVSPGLDGGEQSSPRAPPGLLHKARPGRLPPGRRHPRPRPPARRVARLVRAAVAAAGRLPSPEACPYLRWQRRRRRPTWGPAANGLPACAAGPAREAEVPRAAASVSAAAPAGYITRLGLRAAPRLGCLRPQDALSPTTASAAAGSRPRYPDSWYRDITSNKKFFSLAATYRGAIVGMIVAEIKSRTKIHKEDGDILASTFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHISTTAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVLKDGFTYVLYINGGHPPWTILDYIQHLGSALANLSPCSIPHRIYRQAHSLLCSFLPWSSISTKGGIEYSRTM
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPNLIILVFVGGAFGAMCREFIMLSVPRLADGFPMDIFVANIIAAFLLGLTTSFFKKDKINQYVHLMVGTGIMGGLSTFSSFVFGAVEMMKNPTEVLVSICYLVASLIVGFIAVELGLMIGPKEKPKDPQVASE
The following text describes a protein:
Function:
Transcriptional regulator. Responsive to the second messenger cyclic di-GMP (c-di-GMP) and to the virulence factor pyocyanine, which both enhance gene expression and promoter DNA binding of BrlR. Activates expression of operons encoding the multidrug efflux pumps MexAB-OprM and MexEF-OprN and several ABC transport systems, acting by direct binding to their respective promoters. Also acts as a repressor of the two component regulatory system, PhoPQ. Binds to promoter of its own gene. Contributes to the antimicrobial tolerance exhibited by biofilms, acting, at least in part, by activating expression of multidrug efflux pumps and ABC transporters.
Miscellaneous:
MISCELLANEOUS: Biofilm bacteria exhibit a profound tolerance of various antimicrobial agents, rendering biofilm cells 10- to 1,000-fold less susceptible than the same bacteria grown in a planktonic (free-floating) culture. Second messenger cyclic di-GMP (c-di-GMP) has been associated with controlling the transition between a motile and biofilm lifestyle; increased levels contribute to resistance of exponential-phase planktonic cells to tobramycin and norfloxacin.
Sequence:
MLTIGQLARIFEISTKTLRHYDAIGLFVPARTGSDNGYRYYQPEQIEQLSRILALRRLDVPLEAIDRLKRDGALDDPQRLRHFLQRHQHTLREEISARQRLLAELDRTLATLAHWRIRNMHARIVERPAFSVVGMEYFGSAPGDTIGQLWERFIPREHEIAGKHDPEVSYGICAQQPNGEFHYVAGFEVQEGWPVPEGMVRFQVPAQKYAVFTHKGTAPQIAESFQAIYSHLLAERGLEPKAGVDFEYYDQRFRGPLDPNSQVDLYIPIY
The following text describes a protein:
Function:
May be involved in plant development processes.
Sequence:
MEQYEILEQIGKGSFGSALLVRHKHEKKKYVLKKIRLARQTDRVRRSAHQEMDLISRVKCPFIVEYKDSWVERGCYVCIIIGYCEGGDMAEAIKRANGVQFSEERLCTWLVQLLMALDYLHVNHILHRDVKCSNIFLTKNQDIRLGDFGLAKMLTSDDLASSVVGTPSYMCPELLADIPYGSKSDIWSLGCCLYEMTAHKPAFKAFDIRALINKINKSMVAPLPTMYSSAFRGLIKSMLRKNPEFRPSASELLTHPHLQPYVLKIHLKSSSPRCDNFPTRWSDSSFMKKTKFVENDSMRFSDIGRRRSFSNDRALNPSVSETEQDSLSGIRRVQEIPSYLFEKFTEFSVGIDNEDITADKSTATKFSAVAKTPRLTPAVSVTPRKHIIPSKISKTGQKHDLVPVSQTPSSKSSYSSRRVSLPLPSRTAAIVTPYGANVGSLPTTNSPDVSVNAPRIDKIAEFPLASSNDPVLPIRQTSKCASSSSSIDSADRSITKDKCTVQILEKAVATSNVSDQSLGVAQDGSEGGSEHNRAAVSIHSSSESRQRRFDTSSYQQRAEALEGLLEFSARLLKQQRYDELGVLLKPFGPEKVSPRETAIWLAKSFKETQV
The following text describes a protein:
Function:
Transcription repressor involved in flowering time regulation. Represses the flowering activator EHD1 by binding specifically to the DNA sequence 5'-CATGCATG-3 of its promoter.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing LFL1 show a late-flowering phenotype.
Subcellular Localization:
Nucleus.
Sequence:
MRGEERWQEQPALASHPSRATLRPRGWPRLGLAPTGVGSSCPPAPASELARHLARRAPVSASPPVLPPIKDQGARPPTLAASAAAASSPPPPPPPPIPPLPPSTSTSAARPTDMAGVTSKRRSSSASTSSSSGDGAAVSDRPRGVTRKRRSGGRCPRPAASLRPAAPRPSSHHTAGLRVILQKELRYSDVSQLGRIVLPKKEAEAYLPILTSKDGKKSLCMHDLQNAQLWTFKYRYWPNNKSRMYVLENTGDYVRTHDLQLGDSIVIYKDDENNRFVIGAKKAGDQQAATVPQVDEHISTLFPIFPIAQVDDYLSPMAPQVDISAFVPHADENHEIFDGILNSLPEIPVANVRYSDFFDPFDDGMDMANTLNANANQSASLHVTDDKSGHSLIPNPKSGPHM
The following text describes a protein:
Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for neuroblast specification (By similarity).
Subcellular Localization:
Cell membrane. Cytoplasm. Nucleus.
Sequence:
MAGNIVKWWKHKILGGYKQFTVLQECATDSEELIYPGRAPSACSAPPDLLLTSDREQMLKVKSSASTGSGTGQTKTSFQHSHHHHHHGHHHQSPSSNGHNHSGTSHQQQQQQQHHHHHKSQKDAFRKCTNGKAGGGNATAGGASGAGATNTINTTAATIRSDPDRVRLEEFTCDVSLEDGKKPQPLQFSFTLYDLDGHGKITKDDIAGIVSTIYESIGKSVVVPHYGSKTINVRLTVSPDGKTATTKPASAAVKKAIITPRRRYRSRKLISDDDGSDTSENCPRLLRNRTAATAVTNNGETANNNQAALQNQQQQQQQQHHHHHHHHSNGSSGKLKESNLSKATALAGDNQVNRSIGLSNSSEGSSAVGQLLVEAYHKNNLSPGAANAGAGKGVLNNAPNATKSKANENVYESINNLKCCNLQQQQQQHTASNNTSLQTTASSLPVTATGLNQSTTSTAALICHDCVDGGAPTTTLLPPLSTLETVVIPAPSAGVTGRAKRKLVRKTRASRKTAIAAKMMSEDFARRPRARSLSVGNENCYENVIGRMAAAQEECWKSSLCRRELIEIIRESMVKNSLCFQPNRRKEHHRLAAAVGATRSTQPTPVKLSTALLNQQYPNLSAEQKLTRSINQVEQWLDHRSPKLVPKVKLADDMQLQRTVVSRPLKRSKSKEELTPSNLLLLENLKISEDIAEIAVVTPKKVYNKESLIASATKKNIKTHHQHQHSPSRQPTAVPTVAIGAEKPSAPLTVVNKQSIPVGDAQLVQLQYGSVPINADPSECENLIRMSDDGEDVEQHQHQQHQQQQQTAPMAATKHSYRHHQPQSRSQPQSPQHHQHHHQQEPRYCGSGRAHSVSSASAASTTAVHRYVHEHIHHHYHHFENDPDES
The following text describes a protein:
Function:
Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Sequence:
MTGGVMSQKFVVGAGLLVCSVCSLSAMAGSKPVDLILRVLVDAPPPCSIKGSQVEFGNMIADNVDGTNYRQDAKYTLNCTNSLANDLRMQLKGNTSTINGETVLSTNITGLGIRIENSADNSLFAVGENSWTPFNINNQPQLKAVPVKASGAQLAAGEFNASLTMVVDYQ
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MKMKKTDDILLKRLLLSVGILLFIRMGTFLPIPGINHGHLAFYIQQHPITKNLVSTFSGNDTFVIGLFTLNIFPYINASIMVQLITGLIPSISKLQKEGGGEGRRAITRLTRLITFGWALIQSSSIAFYLKRALFDWSPLLAFEIIVWLTTGAMIVLWLSELITEYGLGNGASLLIYTNIISSLPNLGKKLITENNGSLTLVSGFGIAILFFIAISGIITLQESARIVPLISSKQLSQSQPVVSKVTSNNYIPLRFNQAGVMPIILTTALLVLPNYITNLGVFPLLTLPIFLKSSKIIYWISYFILILIFSSFYSTIVLNPKDIAQELQKMAVSIPGVRPGLATTFYLKQVMKRVTFFGAIILAILATLPNVIEGILNVSSFNGLGTTSLLILVGVVLDISREMKSIILSNIYNERFD
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MKVDSMGNEIEKLKTKEVKLKSKAANQLTQQCAKLCRSEDIKISELEGDVGTLHKTHNVYQSTIVGYSANHRFDAENRNLVSNSPGNGIESGAKHIYNQQQVYGTLVEVAHGSVKDPTARYLKDTDTSKAKVPKKPCYKWGHGGWQSACCITTISMHRLPQISSKYYSRVGGRKMSGRAFSKLLNCLVAQDYELSIPLDLKDHWDKNGTNLYSILK
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MASQDQNTGTTHVELQGGENSKKLFSKYDLWSKAMDEKKLSSSLFTVNDTQEFLELCEACRRGDLEVVKSLVENYNTPINQVDQFDYSPLVLASLCGHEPVVKFLLENGALCERDTFQGERCLYGALNDNIRRMLLSYDITKAIDESQPYASHITSLLSNSALHFTTDIVFAGQYGRVFAHKFYLAARSSYFKSKFSKLGPSEHEIEVKHFAKEFESILRYLYLDTNAVFTKQYNNALLSIGKKFQLNDFIALYEKDREQLHSRDWKKIQLAKTQNDLGEFLDYIISNYKVPIESLNQPSDQYSFHDAYLQSYTHRYPVHRAIMCRCEYFLDMLAGPFLESNQELPVLSLPFSSSVVEIVLKFLYTDKTDIAPELALDVVYVADMLSLDKDRSLKSLASIVITKQEEPIDSIYDILRTAWDTSTPRLEQYASEYMANHLEHLIDDPEFCELVKESADRILQRQETDTIELIDDIRYFLSKRFGIYHEDLCIDGVVDTLTPYESEYNQKMEMIDDLLDKLELQA
The following text describes a protein:
Function:
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Sequence:
MYVSSSIHIKPNFNSSFSVSKTLSKSSSAYCSSGYSSLGFSSTFRSPRWSYGVDWKSPISLKAQIRTAAVTPVLNNFHRKLTTMASENPFKGILTSLPKPGGGEFGKYYSLPALNDPRIDKLPYSIRILLESAIRNCDNFQVKKEDVEKIIDWENTSPKLAEIPFKPARVLLQDFTGVPAVVDLACMRDAMNKLGSNADKINPLVPVDLVIDHSVQVDVARSENAVQANMELEFQRNKERFAFLKWGSNAFRNMLVVPPGSGIVHQVNLEYLGRVVFNREGLLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLSGKLRSGVTATDLVLTVTQMLRKHGVVGKFVEFYGDGMGELSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRSDETVSMIEAYLRANNMFVDYNEPQHEKVYSSCLYLDLAEVEPCVSGPKRPHDRVPLKEMKSDWHSCLDNKVGFKGFAVPKDAQEKVVKFSFHGQDAELKHGSVVIAAITSCTNTSNPSVMLGAALVAKKACDLGLNVKPWVKTSLAPGSGVVTKYLLQSGLQKYLNEQGFHIVGYGCTTCIGNSGDLDESVSSAISENDIVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTVDIDFEKEPIGVGKDGKNVFFRDIWPSTEEIAEVVQSSVLPDMFKSTYEAITKGNNMWNQLSVPATSLYSWEPSSTYIHEPPYFKDMTMDPPGPNGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLNERGVDRRDFNSYGSRRGNDEIMARGTFANIRIVNKLLNGEVGPKTIHIPSGEKLSVFDAAMKYKSAGQDTIILAGAEYGSGSSRDWAAKGPMLLGVKAVIAKSFERIHRSNLVGMGIVPLCFKAGEDADSLGLTGHERYTIDLPDNISEIRPGQDVTVRTDTGKSFTCIVRFDTEVELAYFNHGGILPYVIRQLSQQ
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB33.
Sequence:
MIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVDLLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE
The following text describes a protein:
Function:
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MFALRRNSIVTIQRIFPIAAAVRYGSSTTATGAYGTHNTPVASNETLSREDNKLLDQVIRVDHAGELGANRIYKGQHFILRVTNPRVAPTIQHMWDQEKYHLSIFNKYCTEHNVRPTVLRPLWDVAGFALGVGSALLGTRAAMACTEAVETVIGDHYNNQIRETAHLEDKHPEFSKLREKLAELRDDELGHLNAAVDDWEAQKAPAHGLFTNAIKLGCKTAIWLCKRF
The following text describes a protein:
Function:
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Sequence:
MSAENKIEEITEDQVPQIEENSTIVIKKEEKAARALISKLNLQKVEGITRVVLKRTRQHIFVIANPEVYKTPTGNSYVVFGEAQHEDMQATARAAQIAAAQAQQAAAETGSVSEAAAAGEVGAELASKDPASITADLEAASLSKDEDAEDEAEADATGLEDSDIKLVMEQANVSRNKAINGLKKNDSDVVNTIMDLCK
The following text describes a protein:
Function:
Probable endopeptidase. In tracheal terminal cells, acts downstream of ich to regulate seamless tube growth and/or maintenance probably by processing lumenal matrix proteins.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MFKWVTPASTATLSRCTLPATTAATTTTTAMAATRTATTTTRTTRPQLLSIALTSLIIIVASFVPTTSGFRSIETNGGGRKLFGGYRITPKHCRATKTLPSSDPRANGPTICMFNHECAQRGGEVVGACMDGFLFGACCQIPPTHELASTLINEAQNAYFQQHQQQTKLQQSAAQSSFESYGEQQQSLSEEQVAQQPSQNIYDQQNLDKVYQQLDSSSSISPPNGAYGDEPQQQEYQSESEQPVRDENAYPTSSSSTEATQSQSSSASVEFEQEPSQPADASNDQTTQKINKQPVQPPNFHVHKHSVTINSPSSPPQNDDFVMQVLSTLPPEHADDHHIVFTTEVPTKITSGLQDQTSSESNSFEEVSSTPAATQKPKPKPTQMPTQKTTQKATQKPTPKPTQKAKPKPVPQLAESMKRPIQQKPQQVAKPKPSPKPAQSTNNHHHNHLILDGGEFTHSDITHPGADADLVEDLQFSTGYGPQPVYAEPPKQQQQQQPAEQSYISSSTSAKRPTTGHNSPTTVSSITTHVDSIESIILQLNNTSHGPSYNVVSQQTPSYGYPGAAVVQTEPAAQNPTFYQENESEKVQESDSQSDYGYTTTVNYESFYDKVSDEQDASAAVSQSAEMPTARPGYGEDVSAVLEDHTMPANGYHDAEAPVAPQTSEFNKMPVMGIAYPVDMSYMEEEGNLPATAAGYGQMSSDSYEASTESTYQKLSTVQTEEPQPTYVRPTTNANKQNRPVASYIGMVTMQHYNPQPGNGDYQAQVPPEVSVSSHTTKVQEQMDETSNGYQQSETTSGYVSPPTAVPAPAQRPQYDAVQGDASSERPVLVTASPRPRPKPSTKRPAVKRPISGESTKKKPQPQPSAGAYNQEKISEHSTRKPVSNGYDKVPESPITHIQIKKPSATQHKEQEQTGYPRPASPAGYEQTTAAAPAPAAPSLNYDKPDAPPSQYDQPSAPSASYDQLAPMPSLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPATVDYHYDNVPPLFMADDKLDAFIQSTAENIVGSTPGNYQPPLVATASTPAYAHRPTSSGSYGHKKPGFVQINGTPKPPRPTVLITPKPTAINLVTYSSLSDDSNKLASSTSSYVTGRPGVQGVSSNDFKDPGYFGSSPVHVAFTQSTTEAVYAVPSDDKPAFPGYFGPTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASSAVTSDLDLSTPAFVEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVRVVTTRKPVRTATTTRPKVTTKKPVTRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKVTTTTRRPATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQPGFLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVADFTGRMATVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSITGVK
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MKMKLHVEISSVFLFVFEHRNMKCISCEGKYDGDAGACRQCYEDLKAKVAFLAMSNRYPLTFCTDVVLLASDNGHPEGPAGGMAHEAVLASRSPVFKALLHNETKEIHINELWPQELGAFINYLYTAEICLDQDLARKLLVVAEKYQVHHLKDLCQKFLVSNLNRDNSLATYTFGHHHNDKQIIDAALMLITNNIEKLASSDEYAELKRSHPQLVIEIYEHIVASSTAPSVQALLLEELL