lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Stimulates viral early and late gene expression and thus play a crucial role in the regulation of productive infection. Selectively drives host RNA Pol II transcription initiation at a subset of viral early-late and late promoters without substantially affecting Pol II transcription of expressed host genes. Mechanistically, forms a repressive complex at the major immediate-early promoter region involving direct association with host nucleosomes and TBP. Concerning activation, stimulates transcription by binding nearby, but not within, core promoter regions. In addition, activates quiescent cells to reenter the cell cycle and up-regulates several E2F-responsive genes, which are responsible for pushing the cell into S phase. In S-phase, inhibits cellular DNA synthesis and blocks further cell cycle progression.
Subcellular Localization:
Host nucleus. Note=Colocalizes with host PML-associated nuclear bodies.
Domain:
The SUMO-interacting motif (SIM) is required for efficient transactivation function.
Sequence:
MESSAKRKMDPDNPDEGPSSKVPRPETPVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLTELGDILAQAVNHAGIDSSSTGPTLTTHSCSVSSAPLNKPTPTSVAVTNTPLPGASATPELSPRKKPRKTTRPFKVIIKPPVPPAPIMLPLIKQEDIKPEPDFTIQYRNKIIDTAGCIVISDSEEEQGEEVETRGATASSPSTGSGTPRVTSPTHPLSQMNHPPLPDPLGRPDEDSSSSSSSSCSSASDSESESEEMKCSSGGGASVTSSHHGRGGFGGAASSSLLSCGHQSSGGASTGPRKKKSKRISELDNEKVRNIMKDKNTPFCTPNVQTRRGRVKIDEVSRMFRHTNRSLEYKNLPFMIPSMHQVLEEAIKVCKTMQVNNKGIQIIYTRNHEVKNEVDQVRCRLGSMCNLALSTPFLMEHTMPVTHPPDVAQRTADACNDGVKAVWNLKELHTHQLCPRSSDYRNMIIHAATPVDLLGALNLCLPLMQKFPKQVMVRIFSTNQGGFMLPIYETAAKAYAVGQFEKPTETPPEDLDTLSLAIEAAIQDLRNKSQ
The following text describes a protein:
Function:
Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A.
Subcellular Localization:
Membrane, caveola. Cell membrane. Microsome. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion. Nucleus. Note=Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner.
Domain:
The leucine-zipper domain 1 is essential for its localization in the caveolae.
Sequence:
MEDVTLHIVERPYSGFPDASSEGPEPTQGEARATEEPSGTGSDELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSVSKSLKESEALPEKEGDELGEGERPEDDTAAIELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPVERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGEVEVLKATEMVEVGPEDDEVGAERGEATDLLRGSSPDVHTLLEITEESDAVLVDKSDSD
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. In addition to synthesizing anthranilate, it also catalyzes the second step of the pathway, the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate.
Sequence:
MADILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPANTLQPILEKLYQAQTLSQQESHQLFSAVVRGELKPEQLAAALVSMKIRGEHPNEIAGAATALLENAAPFPRPDYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSDLLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQEQLAGGTPEENRDILTRLLQGKGDAAHEAAVAANVAMLMRLHGHEDLQANAQTVLEVLRSGSAYDRVTALAARG
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MQNKGFVKVFAVLLTLVCVFYLSFSFVTRHYTNKAKEIANGDPKVEQDYLDSLSNEKVMLWNWTLKDCREMEISLGLDLKGGMNVILEVSVPDVIRALADNKPDENFNKALNEAAKQAVNSQDDIITLFVREYQKTAPGAKLSELFATQQLKDKVNQKSSDAEVEKVLRAEVKAAVENSYNVLRTRIDRFGVVQPNIQSLEDKMGRIMVELPGIKEPERVRKLLQGSANLEFWETYTAKEILPAMQSADSKLRAILSQETAADSTATNATADTIPAAKLAEATPAKKAVSVADSLAATLKGDAKDEKAGANMEEIKKQYPLLAVLQLNSSGQGPVIGYANYKDTADINRYLSMPEIQSELPKDLRLKWGVSPSEFDKKGQTFELYAIKSTERNGKAPLEGDVVTDAKDEFDQYSKPAVSMTMNSDGARRWAQLTKQNIGRSIAIVLDNYVYSAPNVNSEITGGRSQITGHFTPEQAKDLANVLKSGKMPAPAHIVQEDIVGPSLGQESINAGIFSFVVALILLMIYMCSMYGFIPGMVANCALFLNFFFTLGILSSFQAALTMSGIAGMVLSLGMAVDANVLIYERTKEELRAGKGVKKALADGYSNAFSAIFDSNLTSIITGIILFNFGTGPIRGFATTLIIGILVSFFTAVFMTRLVYEHFMNKDKWLNLTFTSKISRNLLVNTRFDFMGTNKKSLIIVSAIILVCIGSFALRGLSQSIDFTGGRNFKVQFENPVEPEQVRELIADKFGEDVNVNVIAIGTDKKTVRISTNYRIADEGNNVDSEIESYLYETLKPLLTQNITLATFIDRDNHTGGSIVSSQKVGPSIADDIKTGAVWSVVLALIAIGLYILIRFRNIAYSIGSIVALTCDTIMIIGAYSLLWGIVPFSLEIDQTFIGAILTAIGYSINDKVVIFDRVREFFGLYPKRDKRQLFNDSLNTTLARTINTSLSTLIVLLCIFILGGDSIRSFAFAMILGVVIGTLSSLFIASPIAYNMMKNKKVVVAATEE
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MFPSVPFKSIEDHRKRLELEVAQKAGIAPAEVDEDGHEINPHIPQYMSPVPWYLNAAIQFEAPKKIGNWTQTMPRHGMIEVQNYSMLEIIEKALVKYNSIMADSTELSTSALLQKLDMNMLSQDCGAMTHENKSCTERPRNVGARWTNKHVAPDEKVEALKLNYEAKRGCWNGFKPSTYAHVIERYEARRKYQKEQPLKKLQEKNHNQHMNGKVSDEQDSEDALRVDEAKVDENKQIDFAKVDKCVRTTGVGSTGTVRISGQALEFKQLSMQSLEAFGKGQDIHMQEVPAQAELLHREFMIKKEKLESQMKETILDNYGDASCQEELPRELLLGQCETNVAYDHAGRIIKGQEKSIPNRTYEEDVYINNLTSQVYGVHGGMTINGAISVASKL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MYLRKTKSLNKLLYHLFRLMPENPTYGETAIEVSNKDPKTFFTEELQLSIRETATLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSSVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSITVESGKRVGVAVQQWRNWMLQLSTYLTHQNGSIMDGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF
The following text describes a protein:
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). May also participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor. May also play a role in intracellular vesicle trafficking.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane.
Sequence:
MADEESSSSSLLSKDLKLPPKTARDIGSVDIKEDEDPFGEISTDARARQRLVSEGSTTAEAEEKDLKETCRVAFDKITQYLNGELTASLEDYTLLEQLNNLTTDKYKEMSTMTKSLITTMEKLDDKYKSLQPYLEQIDRIEDSVSSLEQAAYRLDAYSKKLENKFKRLERR
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MEPEKMDENEWNYHGEGNKSLVVSHAQSCVVLRFLKFLPNINKSTEEVYQHLHNILDFGKHIMKQFLGENYVHHGEVVQLPLDFLKRLCLKVQSERPESRCEKEMDVSGYAMCLPNLTRLQTFPFLECRPIFCIEIKPKCGFIPSSAHITKEIKKKVCRFCMHQHLKVAKGKWKRISKYCPLDLFSGNKPRMHFALMNLLQESQNNLKVFKNGELIYGCRDDQEHFLDLNELAHHLKPFFFPASGLISGPQCPKTVVKELIHMLTSVLLNNSTDTARAANIMPIIPLSQGRNYCEASHFCPHLLNSKHATETTGLPTGCILYKTLQTQMLDMLDIEGLNPLYKRVEKYLAEFPEERSTLLLDGPYDETFFEKLKDLSLEDDGSVSYAVTKIQQYRVAMTAKDCSIMIALSPAVQEQCLDPWSVIRSSQSSFIHSVSILDLDLKPYENIPHQYKRDSKIVNHYLKSIKVQEDPVNLYKKSEDCTLLLHKV
The following text describes a protein:
Function:
Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in vesicular protein sorting (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Soluble and partially membrane-bound.
Sequence:
MSSSQNLGGATRCGRVIGPSLDKIIKNAAWRKHTFLVSACKSVLDKLEALSDSPDPSSPLFGLTTSDADAVLQPLLLSLDTGYAKVIEPALDCSFKLFSLSLLRGEVCSSSPDSLLYKLIHAICKVCGIGEESIELAVLRVLLAAVRSPRILIRGDCLLHLVRTCYNVYLGGFNGTNQICAKSVLAQIMLIVFTRSEANSMDASLKTVNVNDLLAITDKNVNEGNSVHICQGFINDVITAGEAAPPPDFALVQPPEEGASSTEDEGTGSKIREDGFLLFKNLCKLSMKFSSQENTDDQILVRGKTLSLELLKVIIDNGGPIWLSDERFLNAIKQLLCLSLLKNSALSVMSIFQLQCAIFTTLLRKYRSGMKSEVGIFFPMLVLRVLENVLQPSFVQKMTVLSLLENICHDPNLIIDIFVNFDCDVESPNIFERIVNGLLKTALGPPPGSSTILSPVQDITFRHESVKCLVSIIKAMGTWMDQQLSVGDSLLPKSLENEAPANNHSNSNEEDGTTIDHDFHPDLNPESSDAATLEQRRAYKIERQKGVTLFNRKPSKGIEFLISSKKVGNSPDEVVSFLRNTTGLNATMIGDYLGEREDFPMKVMHAYVDSFDFKEMNFGEAIRFFLRGFRLPGEAQKIDRIMEKFAERFCKCNPNSFSSADTAYVLAYSVIMLNTDAHNIMVKEKMTKADFIRNNRGIDDGKDLPEEYLGALYDQVVINEIKMSSDSSAPESRQSNGLNKLLGLDGILNLVYWTQTEEKAVGANGLLIKDIQEKFRSKSGKSESAYHVVTDVAILRFMVEVSWGPMLAAFSVTLDQSDDRLAAVECLRGFRYAVHVTAVMGMQTQRDAFVTSMAKFTNLHCAGDMKQKNVDAVKAIISIAIEDGNHLQDAWEHILTCLSRIEHLQLLGEGAPSDASYFASTETEEKKALGFPNLKKKGALQNPVMMAVVRGGSYDSSTIGPNMPGLVKQDQINNFIANLNLLDQIGSFQLNNVYAHSQRLKTEAIVAFVKALCKVSMSELQSPTDPRVFSLTKLVEIAHYNMNRIRLVWSRIWSILSDFFVSVGLSENLSVAIFVMDSLRQLSMKFLEREELANYNFQNEFLRPFVIVMQKSSSAEIRELIVRCISQMVLSRVSNVKSGWKSVFKVFTTAAADERKNIVLLAFETMEKIVREYFSYITETEATTFTDCVRCLITFTNSTFTSDVSLNAIAFLRFCALKLADGGLVWNEKGRSSSPSTPVTDDHSPSTQNFMDADENISYWVPLLTGLSKLTSDSRSAIRKSSLEVLFNILKDHGHIFSRTFWIGVFSSVIYPIFNSVWGENDLLSKDEHSSFPSTFSSHPSEVSWDAETSAMAAQYLVDLFVSFFTVIRSQLSSVVSLLAGLIRSPAQGPTVAGVGALLRLADELGDRFSENEWKEIFLAVNEAASLTLSSFMKTLRTMDDIPDEDTLSDQDFSNEDDIDEDSLQTMSYVVARTKSHITVQLQVVQVVTDLYRIHQQSLLASHVTVILEILSSISSHAHQLNSDLILQKKVRRACSILELSEPPMLHFENDTFQNYLDILQAIVTNNPGVSLELNVESQLMTVCMQILKMYLKCTLFQGDELEETRQPKNWILPMGAASKEEAAARSPLVVAVLKALRELKRDSFKRYAPNFFPLLVELVRSEHSSSQVPQVLSTVFHTCMGAMMDE
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM11 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSQFVLPAVASEGIINWPFLTGFMLGQFSVGLVLLIFVRFFIFSDQTEPDINTQRRTAKVLPTGNPSTDAILEKTYYNTKTHQPESLDWFSVLVAQALYQLRDEVRGNDEVLERLNEILKSDKLPGFLDTINVVDLDIGDAFPQFGACKVNKDESGDLEAEIKVSLEDTIKLGVETKMLLNFPIPKFASVPVSLSVSLVKFSGTLTVAIRSAFNSGEANRVLVSFAPDYELQWKIESSVGSTQKLQNAEKISRLIESRIRRWFKDRCVYPEYQQFELPKLWRKTSAPPPSAGAGTGTSTGVPPSPFPQPANPSSVPKPLELPGGFPHRNMSMSSQRPNINNPKFIRSMSVNTRPTYSSSFYEMQGTAGSSSGSAVADEAYRSLQTSPRR
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MNNSLFLQTVLLFCSIYTTRSEVFTAIAGLEDLLQTESRLIHTLGNYIKDQGKNLEILKRYYQNYKNHYDKASKNVHLHVTNPINAYILIKKLTLDWKRVEVLITRSHNLEWKSRLKNIRKTMQFPTERDLDGALDALIRLQDTYRLDTAALARGEISGVKSSSELSADDCFQIGRKLYETGDNYHTQLWMKEADARLWEEGGTVRRSDILEYWAYSVYKQGNVSLALDLTNKLLEILPYHSRALRNKFYYEQELQNPVDKTKKDQDHVEDVEKEVYKKLCRAEISLPEAKSSKLKCFYQNSNHPFLRIAPFKVEQAHLDPDILIFHNVLSDCEIETMKQLAQSRLVTAVFENPHSKQLELFPFRISKVAWLEDQEHQHLAVVAQRVAHMTGLTLSTAEEFQVVNYGIGGHYEPHFDFQSTVDPAIGSRIETVLFYLSDVEQGGATVFPEIQVSVWPQKGSAVVWFNLHPSGDGDQRTKHAGCPVLIGSKWIATKWIHERGQEFLRPCT
The following text describes a protein:
Function:
Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTYFRINPVLALLLLLTAIAAALPFISYAPNRLVSGEGRHLWQLWPQTIWMLVGVGCAWLTACFIPGKKGSICALILAQFVFVLLVWGAGKAATQLAQNGSALARTSLGSGFWLAAALALLACSDAIRRISTHPLWRWLLHMQIAIIPLWLLYSGTLNDLSLMKEYANRQDVFDDALAQHLTLLFGAVLPALVIGVPLGIWCYFSTARQGAIFSLLNVIQTVPSVALFGLLIAPLAALVTAFPWLGTLGIAGTGMTPALIALVLYALLPLVRGVVVGLNQIPRDVLESARAMGMSGAQRFLHVQLPLALPVFLRSLRVVMVQTVGMAVIAALIGAGGFGALVFQGLLSSAIDLVLLGVIPVIVLAVLTDALFDLLIALLKVKRND
The following text describes a protein:
Function:
Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
Sequence:
MLLAVWGFLRRHKKKCFFLGAFLGGVYVLGKYGQKKMKEIQEREAAEYIAQARRQYHFESNQRTCNITVLSMLPTLRDALMYQLNTESLTSLLKNKPANKLEIWGDLKIISFTRSIVAVYSTCMLVVLLRVQLNIIGGYIYLDNAAVCKNETTLLAPPDVQQQYLSSIQHLLGDGLIELITVVKKAVQKVFMSVSLKHALSLLDLDEKLREIRRAVEEPEDNFTSEETGSHSLLCHYMMPDEENPLASQANGLTEKDITTIKLLNETRDMLESPDFNRVLTSCLNRGFSRLLDNMAEFFKPTEQDICHTASMNSLSSVSLPLAKIIPIINGQIHLICSETPSHFVQDLLMMEQVKNFAANVYEAFSTPQQLQK
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body.
Subcellular Localization:
Contractile vacuole membrane. Cytoplasm.
Sequence:
MICFDNSTAHTDSNNNNNQCDLPENYKELVTTGKVEKLILSPSSSLDRPKTLPPKSQEEVLKHQREYEEIQRKAKKTLEREAKEKEKLDAIRKEKERSLIDARKVWEEDIIPVWEKNSKKRDIKKIKDLSWRGLPPAVRGKIWRLCIGNDLRVTDELFNIFLGHANNAYNKTTSPPLKSSLSSSSKSPNINIDLRQANNSIHHSRSPMNTSTDGEDDVLDLETTNMALILQDIQDTFPSLMIFQKGGPLHSDLIDVLGAYICYRPDIGYVPGMTFLAAMFLLNMEKCDAFLSLSNHINSVCFLPFFRQDQSGIPKYLAAMDSTVEALTPPLHKHFKEIGISAKNYLVDWITTLFSKALPLDVATRIWDLVFIEGEIFIYRTALSILRYFISDLIQATYDECIDLFNKLPQRKISEDKLFEEIQSIVLDQRKFDKLLEK
The following text describes a protein:
Function:
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Subcellular Localization:
Cytoplasm, P-body. Nucleus.
Sequence:
MATKSPVSVAQTAAAVASTGAVASGQKGKQNGSLNISCDILDDLASRFIINVPVEERENLIRICFQMELAHWFYLDFYCAENKHKCGIKQFAQQMFKHVPFLQPHWPNVDTVLEDWKQYKLTVPTYGAILLSEDLKHVLLVQSFWAKSSWGFPKGKINENEEPVNCAIREVYEETGYDIRKLIRPTEYIEVIVNYQFTRLYLVPGVPLATVFVPKTRNEIKCCEWFPVDVLPVTKHDSIVKDNHNLTGNSFFMILPFVKRLKRWLESFPSGGKAAKGAAGKGILAQASNSPVFGRESTGKQKIYFENNIVGSGNKQQQQQQGQKQRQRHKSMGELEQQPQQPIQILQRGKASAAAGTPNVANRSQQKQQQQQQQQQQPREDAYQSNQRAASVVSESYRDFSLGVADESSAMKKKFNQTLPTSAQPLSANVGRGGQNVAAGGSERLVKSQTKRKLFANETAPAKVETENRKEQQQQQQGKEAKKKAAETDDESFLEYLLQEARYDRFRNGVYQWTHFQLEHSTFLFQPILPS
The following text describes a protein:
Function:
Sliding clamp that encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template. During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it.
Sequence:
MKLSKDTTALLKNFATINSGIMLKSGQFIMTRAVNGTTYAEANISDVIDFDVAIYDLNGFLGILSLVNDDAEISQSEDGNIKIADARSTIFWPAADPSTVVAPNKPIPFPVASAVTEIKAEDLQQLLRVSRGLQIDTIAITVKEGKIVINGFNKVEDSALTRVKYSLTLGDYDGENTFNFIINMANMKMQPGNYKLLLWAKGKQGAAKFEGEHANYVVALEADSTHDF
The following text describes a protein:
Function:
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.
Sequence:
MVLIWLLVFSLLHPSGQAAWAPREAEAGALEGRLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQIPPSGRVSGSLENSVYSILEITAVEVGIVAIKGLFSGRYLAMNKRGRLYASENYNAECEFVERLHELGYNTYASRLYRTAPSDTGARRKASAERLWYVSINGKGRPRRGFKTRRTQKSSLFLPRVLDNKDHEMVRLFHSSLRYRESLRKPVDRNERKRRQGHLPVLEAGERDPPEVPSMQASSPPGTF
The following text describes a protein:
Function:
Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis.
Subcellular Localization:
Cytoplasm, cell cortex. Note=Colocalizes with germ granules (P granules).
Sequence:
MSTVSSYFMGISSKKNGSSATANKQSTRPQESHHHRRQQPTSQQSTEMNGTTTAPSGGTSSGTTTTSSGVPTASTGGGSARYSSSSSGRSHPTTGGGSSSHARSSGQSGMSSRSAARRNDQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKATILESVEKEKFEDIHATYLLLGERKSDPSRYSRSSATATGPSITSGAALASAANAQKHQSSAAPASGSSSSRRSSQNDAAASGAGGTVVMSGTRHGGVQMRAQPTSRQAAISLLQPPSYKPSSNTTQIAQIPPLFNRNSTATSSTNQPSSGITAGTRKIDPKGRIPLNSAAVQSHRTATGAVAANTGGIPSQRDHSQQQQQYMNQLTSSSMMSKLINKTPAAGGANATTSATSAAAAPLQKSGSQISHAPTEPVIREDDDESNSEHQNGNVPLIGGVGPQTSPVVAPSEDVTSSEQQKQEKASSEAPKETKPSMIHQSPSMPPSQMMTAMESLKLSESGGKSPSNSQQPPQRATSQQMSRSATTNSAANMASNQQSSGAPQQSGASSQQCHTKPSSTSSSSSSSTTAPTSSGQPHHQHQLTHNASFSVTPSAYQMPTTTTITSGAPTSSSAFPRNTRNRQTFHGKTEKDKGGDDGSDEIGDTPANVSIGATGASANNTEGTIWSKLSKLTRRDHNRESMTQPVSSRAGTIGAAQGQQTAAALAAIREQSSGPLTPGTPPVAQAMTQEGDVKPRSLRFTWSMKTTSSLAPDDMMREIRKVLDANGCDYEQRERYMILCVHGDPNTDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIGFKNIASKIAQELNL
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLARFEVRNEYGLGLPELYKHVDRDDPKAVLDATSVAGLVGILRQLGDLAEFAAEVFHGLQEQVMATACRSHKLKLRVQRIEVALPPLEKAVLSQTSHIHFAYTAGSEWHPRIRNEQNHFIYNDLPRFIMDSYEECRDPPRLHLLDKFDTGGPGSCLKRYSDPTFFKKASATSDEATTERIQIDKKARRSKKKRSSRGNGKLLRGSSISNRSSRLQFGSPTGNGQNSLKTASVVDMKTNSDLGDCSYSFDSRNGQQFKSHGRTSPSHTASTVDMTLKSDPGDRSNSFDSRTGSGYIECVFRPSSSMQPEQPESPSSRLIQHNGTLDSIFPDEQTKAVDDNFAHSSLQEQIASGSSCVTWDEKAEIVEPSDQQSDRDEAPEMLSTKSDIDTHGEIAVSLTNIDQMDSLFDHENSLESISSDNQIDDIESEPDDYMDALNTIESESENDLDFQTKREVEQYASKINDEVINEIHQLPVNSSDHKRSESESDTASCVSSNEGMPSNIPNSVSPESVVLEQIPQISSNLDCPVDDDFDGSSDTLDGSNLESVVNNSLSSTSQISDFKDLSTDEIFSSFCKSQETPADFSGVHSITFWTNGGLLGLEPSKPPDYAMSNAVGQDLANRSKDETVCPSAHGFMLKGNEHEGKQDMLDEKAGDIEKHPSFVSSTSCQDEQEDGVSTKKTTGPSDTDAKCENFSVMAPKTAVQSISSESNQENDENSSLVFGLSRRLLANGLYKKVSHFHDENTEPASSMNAGELEQFSGQHRVVNETIPETTFEDQLGHCSSVYSLTSSPPLEHMKISFHPLNGLETSKLKLKFPDRNQGFEGMRDIFQSFQLVPEPNIPMNDFGFESDDDTFCRSSPYISDDCHSLHSESNSERWESGETPKCKDLELYDSFCGISSTESVYSSLELGGATNNGIHIDGGIRSAKMGNDVEPSLSGGSLLDLPNFDTVNPMLQQVTDEGSNLLKLECSGQPTPQLPPLPPVQWRVSKPHLDEIEGKQDDVSEALTHASDPKYFGSSVSQQPKPSPEKQQQTVKEAVAIEQLGKQQDQQKLNEQKEANQATNVKEMDEREDFLHQIRSKSFSLRRTMTPKPTYAPGPATNVKVTAILEKANAIRQAVGSDDGGDDDDTWSDA
The following text describes a protein:
Function:
Dioxygenase that catalyzes DNA N(6)-methyladenine (6 mA) demethylation to modulate gene expression and regulate seed germination.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MYESANVSDDADRTAFRRAEKKYKLYYEQDSKFSRKKKLPKPIDLSELLDFNLISQNFNNDGVLPDGIRVSKVDSSPVFCIDNRPGFYFIPDALSLKEQCKWIKESLTSFPQPPNRTNHNAIYGPIDDLFDSAKENKVLVQDDLTNNKWKFYEEVDIEKATRSSCKSVSASVLLRKLRWSTLGLQFDWSKRNYDVSLPHNNIPDALCQLAKTHAAIAMPDGEEFRPEGAIVNYFGIGDTLGGHLDDMEADWSKPIVSMSLGCKAIFLLGGKSKDDPPHAMYLRSGDVVLMAGEARECFHGIPRIFTGEENADIGALESELSHESGHFFAEYIKTSRININIRQVF
The following text describes a protein:
Function:
LEA protein are late embryogenesis abundant in higher plant seed embryos. There are two subsets of LEA proteins (5a, and 5b), the first ones are expressed when the cotyledon weight reach 80 mg and the second set are expressed above 100 mg. The function of those proteins is not known.
Miscellaneous:
MISCELLANEOUS: This is a SET 5b protein.
Sequence:
MAHFQNQYSAPEVTQTDAYGNPTRRTDEYGNPIPTQETGRGILGIGGHHHGGHHGLHRTGSSSSSSSSSEDEGTGKKKKGLKERLKEKIPGNKEHQSQATSTTTPGQGPTYHQHHREERSDGQDQGEAPWSPQPLISCLWSAISY
The following text describes a protein:
Function:
Transcriptional regulator that regulates glycogen accumulation in response to the amount of glucose available to the cell. Acts as a repressor of the yegTUV operon, which may be involved in glycogen accumulation. Binds at two adjacent sites within the yegTUV upstream region.
Sequence:
MEQAHTQLIAQLNERILAADNTPLYIKFAETVKNAVRSGVLEHGNILPGERDLSQLTGVSRITVRKAMQALEEEGVVTRSRGYGTQINNIFEYSLKEARGFSQQVVLRGKKPDTLWVNKRVVKCPEEVAQQLAVEAGSDVFLLKRIRYVDEEAVSIEESWVPAHLIHDVDAIGISLYDYFRSQHIYPQRTRSRVSARMPDAEFQSHIQLDSKIPVLVIKQVALDQQQRPIEYSISHCRSDLYVFVCEE
The following text describes a protein:
Function:
Involved in brassinosteroid (BR) signaling.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MAKAAPDSQSNRAAVQATNDDASASKLSCVRKGYMKDDYIHLFVRKPVKRSPIINRGYFARWAALRKLLFQFLNVGSNTEEHTKKQILSLGAGFDTMYFQLQNEGNAPHLYVELDFLEVTSKKAAIIESCSQLREKISGTVSISLEKGEVHSDHYKLLPVDLRETNQLNDVLVLAGMDPSLPTFIIAECVLIYLDPDSSQAIVGWASKAFSTAIFFLYEQIHPDDAFGQQMIRNLESRGCALLGINATPSLLAKKNLFLDQGWQTAAAWDMLKVYRNLIEAQERRRIERLELFDEFEEWHMMQASL
The following text describes a protein:
Function:
Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression.
Sequence:
MRFDLTDLKLFIHVAESGSITAGAERAHLALPSASARIRGMEETLDVPLLQRGRRGVEPTEAGRTLLQHARDITRQVEDMHADLAQFATGLKGQVRLLCNTSAMTEFLPDALAAFLKSHPQLSINLEERMSRDIVQAIADGVADIGIISDAVDHANLRTFPFRDDPLVLAMARGHPLAKALGLKRHMPFIDALDHDFIGLADDSAMQRNAAEQAARLGRRLHCKIRLRSFEAICRMAASGAGLALLPATAARRSPDDLRVIKLSDPWADRKLLICVRDPAALPAYARELLAALTLA