lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity).
Subcellular Localization:
Cytoplasm. Note=Localizes at mid-cell.
Sequence:
MSQSNTLTVQILDKEYCINCPDDERANLESAARYLDGKMREIRSSGKVIGADRVAVMAALNITHDLLHRKERLDQESSSTRERVRELLDRVDRALANPADAGEA
The following text describes a protein:
Function:
Possible subunit of a heme lyase.
Sequence:
MSLRQRTARLLLALLLGMLLAPPLAAQAVDPLPFKDRNEETRFQRLTAQLRCLVCQNENLADSNADLARDLRHQVFAQLQAGRSDAQIKQYMVERYSDFVLYDPPVKRGTWLLWFGPLLMLGAGAAVVLHTVRKRARAGTPVAPQTEEDW
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDDNDDGLMLNFAAPAAGSASVSSKRSKQTAKARFAQKRTAHQLRKQAPKQNRSVAPIESVQGVVTPASARLSPAPASANESPAAKRQRIEATSTSSAALSAPRFDPRSETAKSAPITSRSSQTTSSAASSSRKAIAPVTKLAGSSFASAGASSSASKQTNGGIVSTLFPAHGVLEDSSIALTPFQRKAYHPTNAPSVGSDFASCGLDPLLVYHLASKMNIGSNPTAIQKAALPHLLHPGLDRDILIQAQTGSGKTLTYLLPIVQSLLPLCEESFIDRSVGTLAIVLAPTRELARQIYEVLEKLVSLALSLKEQNQEVEGTVRRTRWLVPGLLSGGSTKNHEKQRLRKGCPILVSTPGRLLDHLQNTSSFDVGKCRWLVLDEADRLLEMGFEEQLTGIVRALDGRRNLACTAARQAMPAYQEGTAPGDADWIPDADVMDTLGMAWWAHARRVVLCSATLDEHVQVLAGKTLVNPKIIRGVKSDAAETSTQVTTDADSTLQKRAVKFAAPAQLAQSFVTTPPKLRLVTLLSLLRSYISRARRQWQHVDHQAGAGRVIVFMSCTDSVDFHYAAFGGARMNASENDASADVQVQDAQLATHVTSELIPDVPIYRLHGSMTQQERISSLKGFSGIRTKHSAERQGFQGSILLCTSVASRGLDLPEVGCVIQLDPPTEGGIEEYLHRVGRTARVGRAGESWLLVLPQELGWVEHVLESHMTIQSSDSASCSCSEIESKKQGSTRKITPASIELVLQQGMGGTMGTLEYQSRATEVQLAFERWVISGERPSLLARKAFLSHVRAYATHSAEEKQYFNVRALHLGHLAKAFALREAPRSLGAKSSAIGASSTPASSHETTNKKRMRIAPDTAESDSSSDSSDDAGSDYESHSNKKGDAFELDKAALAKLTESIVANADGSNRSKKLAREAQKAAAAAGVADDKAKQTDAEARMYAKVRALGKMSKKHGVLGAHAADEFQIA
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biosynthesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MALKELLGSDAPLEKVCSALLEYESKRKSSENIDSESKKTNLLEDEQDDIEPVWLQLATLKFIGNNRKLIPYKIAIKNPVIPSSSEACLIVKDPQRVYKDLVNEAGLSKVVTRVIGLSKLKAKWNSYEQKRQLRDQFDIFLADDRVIPMLPRILGKTFYQKSKVPVPVKISKGTAEQLKREVVSAYGATYFNSAPCSSFMIKCGHVSNTSTELAENVESILQFVSKHIVPDGAKGIASIHLKTSQSIAIPLWNNPNLKELIASSRKVVTKETASSKRKSDEESLPSQKKQKKVEVAKESKDSKQQNVSDKKQVTVKEVPKKLSVKNAAKTTNRDEDSKGKKAKASPKVSQSSLKANGTTAIKKVKAGKNKVKH
The following text describes a protein:
Function:
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) into (2Z,6E)-hedycaryol via a 1,11-cyclization.
Miscellaneous:
MISCELLANEOUS: The 1,11-cyclization requires isomerization of (2E,6E)-farnesyl diphosphate (FPP) to nerolidyl diphosphate (NPP), the abstraction of the pyrophosphate from intermediate NPP leading to a (Z,E)-hedycaryl cation and finally an nucleophilic attack of a water molecule.
Domain:
The Asp-Asp-Xaa-Xaa-Xaa-Glu (DDXXXE) and Asn-Xaa-Xaa-Xaa-Ser-Xaa-Xaa-Xaa-Glu (NSE) motifs are important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MAEFEIPDFYVPFPLECNPHLEEASRAMWEWIDANGLAPTERARDRMRRTGADLSGAYVWPRADLDTLTIGLKWIALTFRIDDQIDEDDTAERLPARMTAIDELRGTLHGLPVSGRSPTARALGALWQETALGRPATWCDAFIGHFEAFLQTYTTEAGLNAHGAGLRLDDYLDRRMYSVGMPWLWDLDELRLPIFLPGSVRTCGPMNKLRRAGALHIALVNDVFSVERETLVGYQHNAVTIIREAQGCSLQEAVDQVAVLVEAQLHTVLQARQELLEELDRQALPSRAREAAVDYAANVAANLSGQLVWHSSVERYAVDDLQSAADPRATPTTSSLGI
The following text describes a protein:
Function:
Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: GPI-anchored form.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGELPPNSVGVFLALLLCSCSLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVHMGVMATMCRKAKRSPSEIDDEAKLGSGQLVKEPPPSPLPLPPPVKLGGSPMSTPLDEKEPLRTPTGSIKQNSTIEFDGRFVHSRSGEIIGKNSAV
The following text describes a protein:
Function:
Required for efficient mating. Plays a role in maintenance of cell wall integrity during mating. Important for mating cell projection shape and conjugation bridge diameter. Plays a role in cell fusion and nuclear migration.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Periphery of the mating cells. Localized to the mating projection.
Sequence:
MNSFASLGLIYSVVNLLTRVEAQIVFYQNSSTSLPVPTLVSTSIADFHESSSTGEVQYSSSYSYVQPSIDSFTSSSFLTSFEAPTETSSSYAVSSSLITSDTFSSYSDIFDEETSSLISTSAASSEKASSTLSSTAQPHRTSHSSSSFELPVTAPSSSSLPSSTSLTFTSVNPSQSWTSFNSEKSSALSSTIDFTSSEISGSTSPKSLESFDTTGTITSSYSPSPSSKNSNQTSLLSPLEPLSSSSGDLILSSTIQATTNDQTSKTIPTLVDATSSLPPTLRSSSMAPTSGSDSISHNFTSPPSKTSGNYDVLTSNSIDPSLFTTTSEYSSTQLSSLNRASKSETVNFTASIASTPFGTDSATSLIDPISSVGSTASSFVGISTANFSTQGNSNYVPESTASGSSQYQDWSSSSLPLSQTTWVVINTTNTQGSVTSTTSPAYVSTATKTVDGVITEYVTWCPLTQTKSQAIGVSSSISSVPQASSFSGSSILSSNSSTLAASNNVPESTASGSSQYQDWSSSSLPLSQTTWVVINTTNTQGSVTSTTSPAYVSTATKTVDGVITEYVTWCPLTQTKSQAIGISSSTISATQTSKPSSILTLGISTLQLSDATFKGTETINTHLMTESTSITEPTYFSGTSDSFYLCTSEVNLASSLSSYPNFSSSEGSTATITNSTVTFGSTSKYPSTSVSNPTEASQHVSSSVNSLTDFTSNSTETIAVISNIHKTSSNKDYSLTTTQLKTSGMQTLVLSTVTTTVNGAATEYTTWCPASSIAYTTSISYKTLVLTTEVCSHSECTPTVITSVTATSSTIPLLSTSSSTVLSSTVSEGAKNPAASEVTINTQVSATSEATSTSTQVSATSATATASESSTTSQVSTASETISTLGTQNFTTTGSLLFPALSTEMINTTVVSRKTLIISTEVCSHSKCVPTVITEVVTSKGTPSNGHSSQTLQTEAVEVTLSSHQTVTMSTEVCSNSICTPTVITSVQMRSTPFPYLTSSTSSSSLASTKKSSLEASSEMSTFSVSTQSLPLAFTSSEKRSTTSVSQWSNTVLTNTIMSSSSNVISTNEKPSSTTSPYNFSSGYSLPSSSTPSQYSLSTATTTINGIKTVYTTWCPLAEKSTVAASSQSSRSVDRFVSSSKPSSSLSQTSIQYTLSTATTTISGLKTVYTTWCPLTSKSTLGATTQTSSTAKVRITSASSATSTSISLSTSTESESSSGYLSKGVCSGTECTQDVPTQSSSPASTLAYSPSVSTSSSSSFSTTTASTLTSTHTSVPLLPSSSSISASSPSSTSLLSTSLPSPAFTSSTLPTATAVSSSTFIASSLPLSSKSSLSLSPVSSSILMSQFSSSSSSSSSLASLPSLSISPTVDTVSVLQPTTSIATLTCTDSQCQQEVSTICNGSNCDDVTSTATTPPSTVTDTMTCTGSECQKTTSSSCDGYSCKVSETYKSSATISACSGEGCQASATSELNSQYVTMTSVITPSAITTTSVEVHSTESTISITTVKPVTYTSSDTNGELITITSSSQTVIPSVTTIITRTKVAITSAPKPTTTTYVEQRLSSSGIATSFVAAASSTWITTPIVSTYAGSASKFLCSKFFMIMVMVINFI
The following text describes a protein:
Function:
Negative regulator of PRP3 and PRP4 genes.
Subcellular Localization:
Nucleus.
Sequence:
MAYDEDDGEINFNELVGNLLSSHNQEGQEEGEVQGGEQEGDDFEKIYPTSENIEPKHPDDSQHMHNSPDQNIEIPHFVDEEDELVSVVANAVQNIDDEQAKPENHLENGSEHVTSDTADDNHEKEQQQEWAHILQQEILKSDGEPLRENTERRVSTSQHHPSQRTDDALDQDDENLRMAILESLQELNTNEEEEKEPEKHEHAAPNDKLSSKKSSKKKKKDKSKNRESSKDKSSKKSKSSSHSKKHAKDRNKEKQSKPTNNENTLDLSNILENLIHENDNAAIDTAKQTVDIQDNSHTDNTNNEDVEAQALVEATLKAFENELLSSAPTEEPSQEQSIGPVSSRKAVEPPRKPTADDIPLAMLQAFKPKKRPPQEKKKTKSKTSKAASTANKSPASESTSKKKKKKKTVKESNKSQEAYEDDEFSRILADMVNQVVNTSLKETSTHTATQDNKLESESDFTSPVQSQYTTEDASTANDDSLDLNQIMQNAMAMVFQNQNDDEFDENIVEDFNRGLGDLSVSDLLPHDNLSRMEKKSVPKSSSKSEKKTAISRRASKKASRDASSVELTEVPSKPKKPSKTEVSLEKKLRKKYVSIANEAASVARKKRWAKNKELKEKEKLERQTAREERRHKKKLEKQRLAEEQEELKKIVERGPPYPPDLRLTKSGKPKKPYRRWTPEELLKRSQEAEKPRKVKKERKKKEKKMKVPSSALKKIPLFNFVKGNVQPSARHRLNDIEGSLSTIGLHKSPDGVRRILSRPKSEDHEWPLSDSSASQNYDAHLKTVVHKEKIPFHPPWTIPSQPPFALPVARRKKIPNIKKYRKRTNNSFRVSKEGTASTRNRILPAILLPIINTLKAAAKSQTAAGATPEEARKRLATIIQHAKSTVIRAALQARKNSMQAAHSKGTTTELATTASRMKNPLKMIPIFNTSRVKQQLDKQLPARSAGTEISSSESPDKATPDPHSNSTIAGHTLKGVTTPIKIEDSDANVPPVSIAVSTIEPSQDKLELTKRAESVEPVENNVETAKETQSVQEIKENVGTKASEEVTLTEDKTNGDPKNEKRILIESPVEKTDKKKPGEKIATDLNEDASLSDKKDGDEKSTLHSDAAQLTGNEPDSVNTTTGKPKLIDVSLKPLNEAKPKIPIIFPLKRPQIKPEVSVINLVQNLVNTKIPEIKNESVDLGSNITDILSSTITNILPEITATDVKNYQYEDENVKYLKKTPRQVLNLDGLVPPSGRCITKAKRVRRIKKLSADATTAPEADGKANSESITYTFDIPSPEEVQSKRSVVLKFAKARLTEAELSCLKKEINNVRKRRWREMNSTKNWEYDVKSRLKKRANAFFGEGESETKSKWIEERFQEKVSQEKYKDRLETTETQANNTKIVIDDKEILNILAVNMNNLNKARCIEKDIQESFREEKLASLQPKKKRKKSILH
The following text describes a protein:
Function:
Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus.
Miscellaneous:
MISCELLANEOUS: Present with 6330 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes constitutively to the cytoplasm and the nucleus, independent on osmotic conditions and phosphorylation status of the protein.
Sequence:
MSTIPSEIINWTILNEIISMDDDDSDFSKGLIIQFIDQAQTTFAQMQRQLDGEKNLTELDNLGHFLKGSSAALGLQRIAWVCERIQNLGRKMEHFFPNKTELVNTLSDKSIINGINIDEDDEEIKIQVDDKDENSIYLILIAKALNQSRLEFKLARIELSKYYNTNL
The following text describes a protein:
Function:
Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR. Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy; Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR; Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion inner membrane. Mitochondrion outer membrane.
Sequence:
PPPISPLSREPRRPPARGWTCRWLSSRHLPPTAWDALSWVRAGGGGRTPPCPTRSGESPPEESQDSGRRGYLAPESAPKVSRSGPTPSRAAAGLGTTGCPGPVPPILGICRSPPRTARCPSGSDLAPGPEGPGDRAEDTGRGADVRGWGLAGRGSGADPRARGGGGRASGPPPPRGQVRGPRPPQGALAVLALQLARQVHFRARSLRSGGTEPEARGAPPSCARSPARRLPQDFALRRNVPPEARALHPPPTGARDPGADPPPDPPDGGRSRTAEPRRPRGEGERQPWVGGRGAGESLGTLPHFGEAGGPGGGPVQVSPSPPLKSPAMVSSWTSTPPRVSGQGRTRTGHRTRGGYGGALPGGELRGAREGGDSSREVRGREVQLPQRPGPPVPSPLPAQQEKAGPEGSVEEAALSLQKLYQLSVALVLNVLGTESMRQGRCGSAFSCFLQAAARGYAKAQYNAGLCLELGRGTRRDLSQALLYYERAASRGHLLAQYRYARCLLREPAAEAGHRGASSALERLAEGGLTEAQAFLGVWLIRGPHRDERRAVHFFRLAAANGDPQSQYHLGVCHELGLGVQRDVGTAARCYRRAAAQGNPRARERLSLLLPSPPAR
The following text describes a protein:
Function:
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Sequence:
MEDEDEEEKEKNILLLQSKMKDRLPELLELSQQYDQRFPDEANERNGSQENIIFETDHILESLYKDIQDIQTENHLLIVDVKRLGKQNLRFLTSMRRLSSIKRDTNSIAKDIKTRGEAIHKKLQMMKTFCEVAELKHGANSAMARISKAQYNVLTWTFQQAMHDYNQVEMNQRENCKIRIQRQLEIMGKDVSRAQIEEMCEEGKWDVFSENLLSDVKGARSALNEIESRHKELMKLESRIRDVYGLFLQMAVLVEEQGETLNVIELNVEKTQSYTGEAKAYVKKAVEYKKKNPCWTLCCCCCRCCN
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MKFCIIGYPVRHSISPRLYNEYFKRAGMNHSYGMEEIPPESFDTEIRRILEEYDGFNATIPHKERVMRYVEPSEDAQRIKAVNCVFRGKGYNTDWVGVVKSLEGVEVKEPVVVVGAGGAARAVIYALLQMGVKDIWVVNRTIERAKALDFPVKIFSLDQLDEVVKKAKSLFNTTSVGMKGEELPVSDDSLKNLSLVYDVIYFDTPLVVKARKLGVKHIIKGNLMFYYQAMENLKIWGIYDEEVFKEVFGEVLK
The following text describes a protein:
Function:
Galactosyltransferase involved in the biosynthesis of the bilayer-forming membrane lipid alpha-galactosyl-glucosyldiacylglycerol which is involved in maintaining constant nonbilayer/bilayer conditions (curvature packing stress). Also involved in the beta-lactam resistance. Catalyzes the transfer of a galactosyl residue from UDP-Gal to alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol) acceptor to form the corresponding galactosyl-glycosyl-DAG product (3-O-alpha-(D-galactopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). It can only use UDP-Gal as sugar donor and alpha-glucosyl-DAG is the preferred sugar acceptor.
Subcellular Localization:
Cell membrane.
Sequence:
MRKFPLFSSSLSFLLLILFKENDIIVVMEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVTENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKGIVKRYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLRTDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYKTIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRDLDLYKVILEGNYRATAGREEMKEAILEYQANPAVLKDLKEKAKNISREYSEEHLLQIWLDFYEKQAALGRK
The following text describes a protein:
Function:
Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
Sequence:
MNEARFHDLVDALQQQVEDAFDDSDLDLDLENAGGVLTVRFENGSQLILSRQAPLRQLWVAAKSGGFHFDYDEASGLWRHDGSQEPLGALLNRATLEQGGEDVEFPGL
The following text describes a protein:
Function:
Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MALSFSQTTSVKLSEFLGKNVLDLKGMDARGKLSFPVNPLWNVEKIKFYIYYKASPVLKSERSEITLLLNGKVITSRQIKDEGLITVEIENPKLFDFNTLTFKASQHYCINCCENENSPELWTQIDLKKSYIQFQYTKKPFPENLAFLKDIYLSERLLSPVEIDILTDKGSNRLLTAGAIFSGYLGAKIKYRRIYVNYTENLRAKDTVVIGTQDFVSRVIGERVSGNIYVTQNPKDKSKFLLVFTGRDEKEILNAVRAFILTPSSYLSEKFVYVSDVVLPEIKAYSSPVLLAPGEEITLRKIAGGDVVVRGYAGRFDFSFFIPPDLMLNPKEKLRLKLFYNHGLLVREGSTINLYINGKFVYSIPVDPYDKSDLKVREVLIPTSVLNKGFNVLTVESALVPNKEDFCAAANFESLKVIIYGNSLISLPDLVHWTKMPNLVYFISTGFPFTTYPDMKDAAVLVESTDGETLSSMFTLLAFIGTKIQFPPLRLSVYVDRLPNDVAQSKDVIVFWNRNSLIKKQILNSLDSVVLVKGKLFEEDQKEFSVNLRKRDYVFTMAMRESPFKPKRTILVLNSKSPGTLHKFVKMLYDPVVLSKIKGDTVFYDEKTDTILSSSSGQVYYIGHMPVYKKVYYEIGYNLKYLVGLLLISLLVLAFATKKLLDYRAKKRHQQEEKEGKEEEKK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAAPEVPSNKINLSMLIDFLLQKTYHELTVLSELLPRKPDIERKIEIVQFASRTRQQFVRLLALVKWAGGAKGVAKCQAISTFLDQQSMVFVDTADMLARMARETLVQARLPTFCLPAAVDVLTTGTYQRLPTCIRDKIVPPDPLSLSEKNKTLQRLNEVIQHRLVLARIPPQMASLKIADGCVTFHVDNEFEVSLTLMGDDPALPWRLLSINILVEDIETGDGKPLVHQMQYIFRRYFFNYCPDSFCLSLQLQVLHFQAKQLIHERWHENVKIESYAVGKTLTLSYWRTSPSQHSQRQVQGHAMTISYQSDQNPGYLSISHQPPLPVNSKEDCLDKVMPSNLCIERLLMQSVRLQSITNLKNLLSLLSEHINSKEPPKLLPGKYCDAVCIMHMTSVEYFFLNLLSLLSEHINSKVLLDRCMPSLAIQTCKQATPSEVLIIAVDTRTGNFKVSLGDGEENLICTDMEKALNADPQKFPTLLGDARCQLHLHKCRRSVSLLPIMPLSYLPLTEVSRGKLCMLSKHHMFLKFKNHPNFFLVVEVSSAAESDKVCVKYSLLRTKSVDVDNLEPEVSRRDSTVKQEDKGGASMPAGNVQPLFLAVKHIVEVSPERMTDFPGTMIKGFSDGKMESVPVKRKHDYCEEERAKRIKTTTELYKKCTNTSSFQAELSHIVCSCDGRIPFVSLCEDLRRHGVVHSGVTSEAAVGLCVEIPHLPTPQGCKEDLVTTLHSNMISCTLRFSGQEYAHCDFEMYFAYPPFLTDSEKLQAKRIALKYAYTQPEPGASEPGVVQKFLDDWCCICKLYAHALDLDMCIKDNQSHVRHMFRVESYTYRQLTLQYEPDRQNMVTVEWSVAESKFLLSFSHSGSSDTDNPHRIMAEQLQKDFNKRLNLPYLMQILHETWKPLTALGRLPTRPTLGVITRPLMPYRTFAVIPQSPTSVHLLYRPTHALEIHFKAKNLLSIRDASISSVDPTKPMGMLQTITNLKLFLQIYVDDIAKAGGIPSRRASGADDEGPPSPLNTEMEPPIDVQFTSPQPMPGRNSSPIVPRASPQPPTARPYGTSPGTSAMSPSNPYSSPSPITHYMVNSPAPYHPMASPAMSPGGQVPKYRQSGAVAVTSKLPTTPPRPLIARGWALTTPTILSHAAFTKLCSPVMSVGRHGNVSPLEMFMGSMFLKKHFSRAAASDDLVRSRIDSLSYSDDLVRSRLESLSYSDDLVRSRLDSLSYSYDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDALSYSDDLVRSRLDSLSYSDDLVRSRLDALSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSCLDSLSYSDDLSDDLVRSRLDALSYSDDLVRSRLDSLSYSDDLVRSRLDSLSYSDDLVRSRLDALSYSDDLITIVKADASRILFKVNNNSPQCNLQCVLSMDTKTFTSLRLNLSPIQPQDTMWTHDVLRTLERFFDTRVACPPYKANSMTSFVRILTAAPKILLDLIRLIKLEMIELTRQGVPGGAGTRDESSVFVPLLYHPQTNTTQQAEMTREPGTQSSSSAAISAFLRRWNESVASKTTECTLFLAVQELAKNLVLPTSPSLNDH
The following text describes a protein:
Function:
Ribosome-dependent ATPase that functions in cytoplasmic translation elongation. Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity). Assists translation termination by stimulating the release of nascent protein from the ribosome by release factors (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAPYAPTDGISKLAIDQSKHFTEALKEALKSSADQQKVAAEKVSELVAGDANLNLGVVSQELRNALTGNDADAKVVAAHVVDDLMQKHAERVEAYLLPLLSVFLDLLGDKKPTVRPVAQEAALTIISSANKNSTIRILPILFDGLDRSKKWQTKKGALDLIAELSKVAPYQVGRCLPDIIPQVTDCMWDTRKEVKVAARDTMTKVCNVVGNMDIEPFIPALVSCLANPTEVPECTHKLASTTFVKTVEAPALAIMEPLLKRALAEGKTAVKRQAAVIIDNMCKLMDDPAEAQLFIPKLLPGLKKVIETQADPECREVATRAHETLFVAGGSMEVSEDELKVDYANIHKVVVESIAANPTAVKANIDSFVVDYVTGICYFLVVSRNFNKAVFEKEITTYIKAFMKPEEIKPLANEIRDRCFKENKSIFIEDVDCDEGIPDLCNCEFSLAYGGMILLNNARLRLKRGHRYGLCGPNGCGKSTLMRAISNGQLEGFPSRDELKTVFVEHNLQASEAELSVVDFILVDEDLKNTPRKEVEDTLAGVGFTAEMQAQGVGTLSGGWKMKLELARAMLQKADILLLDEPTNHLDVKNVAWLENYLTSLTNVTSIMVSHDSGFLDTVCTNIIHYETRKLKIYKGNLSKFVEQKPEAKAYYELESENVKFIFPEPGFLADIKNKGKPIIRLTNCSYQYPGTPKPSINNISVTCALSSRIAVLGPNGAGKSTLIKMLTGEVEPTSGQVWKHPSMRFAYVAQHAFHHIESHLDETANQYIQWRFQSGEDKELLAKETRKLSKEEKEHYKKPVNWEGEKRVLEEIVSRRKFKKSFEYELKWEKCPVDDNAWVPREKCEKWGWDKLLQIADDREAARANLQARPPTAIAVQKHLDCFGLGAEFGTHSRMRGLSGGQKVKVVLAAAMWLNPHILVLDEPTNYLDRDSLGALASAIKEFNGGVVMITHHNEFSSALTQETWNVEAGFLVIEGQQAEDKTKIEQKNEEEVTDAFGNVTKTKIKRKLTRKEKKAKDKARKEAEARGEYYSDSDEE
The following text describes a protein:
Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Sequence:
MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKNTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHVFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMSGNNLTSTEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSVTGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQEESILDGIIRELQREQDLRLINEGDVPHFPINRSYSVNGALSSPNMDIPSSPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNSGVSRVQEECRNAKGDLEVSLYTVEKKKKPSYPIQRNDYQPSCGRSLRRTQRKRQHTYLTRSNIEHNSQASSQNSGVQGDSDSSSEEDETVGTSDASAEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKIYSSSEDENVKSSEDRQKKPKQTRKKKGGLVSMAGEPNEEWLAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGIPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINNLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIKQRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAENPNSSDPEEDTEMVDLDSDGPGTSSGRRAKCRGRRQSLKCNPDAWKQQCKELLSLIYEREDSEPFRQPADPHSHPAQQQEGESSESVPPDRQDPSLSEDYQDVVDTPMDFSTVKETLESGNYDSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFENRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSRAPSPKGKQKQMKLQPKNDQNTSVVYARTSSPFSSPDHSLDGPLTNVDGREPRTGAKRKLLSASEEDESMGGEEKEMKETKEKAHLSSSESGELGSSLSSESTSGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRRQHATGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGGRGRGGGGGRGRGRGRGGRGASRGASRTKRARVADDEFDTMFAGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY
The following text describes a protein:
Function:
Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Cotrafficks with CLDN19 from ER to tight junctions.
Domain:
The first extracellular loop contains negatively charged amino acids that affect cation selectivity.
Sequence:
MKDLLQYAACFLAIFSTGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSIYAEHPLKLVVTRALMITADILAGFGFITLLLGLDCVKFLPDDPQIKVRLCFVAGTTLLIAGTPGIIGSVWYAVDVYVERSSLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGALLTCCLYLFKDVGPERNYPYAMRKPYSTAGVSMAKSYKAPRTETAKMYAVDTRV
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MIIMITNTFILGITGPTSLVVISIIALIIFGPKKLPQFGRAIGSTLKEFKSATEDLDKESHDTPSKESKQQREQ
The following text describes a protein:
Function:
Plays a role in development of both male and female reproductive tissues.
Subcellular Localization:
Nucleus.
Domain:
The cysteine-rich domain CRC binds zinc in vitro.
Sequence:
MEDLSNQNLLPRQSDISIPAEKMDSFQKSLEPPPCSPVKSSQQSETEVTPPQKPPLHQFGHNQVQKNRVSNQDPSTSRRHNEVESKENTPNKQQKHCNCKNSKCLKLYCECFASGSYCNGCNCVNCHNKLENESSRQVAISGILERNPDAFKPKIAGSPHGMKDLQENVQQVLLIGKHSKGCHCRKSGCLKKYCECYQANILCSENCRCQDCKNFEGSEERKALLHGSQVSDTYIQQMTNAAVNRAIDMSAYLYPPESRKRKSKDISDSVVSSYGVQYQRANHVRRNGENSLFSLPNNKAVSGSTTSAYRSSWSNTFQPHHVRELCSLLVSNSVDVANKLSDKGRKNDKGPSSLDGAQRVANEINDSPDCVLDANRMDEKPISPATRALMCDEEHEIGSEKETSARVKTSQEKEDTDTSSGIYLEQERQILSIFRDYLIQLSNRARINGKNIKSNTNPS
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MTSPLLESRRQLRKCAFQALMSLEFGTDVETACRFAYTHDREDTDVQLPAFLIDLVSGVQAKKEELDKQITQHLKAGWTIERLTLVERNLLRLGVFEITSFDTPQLVAVNEAIELAKDFSDQKSARFINGLLSQFVTEEQ
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MSSSNLEQYLAAALCRHTPAAATATAAPAGAGGGTPDLAAVAIQRQKAAQRARFTTAAFSAEFAPARSLADQYFSRREQVKGLEDQLRDIQSQRSEAATLQSRKEPKIERATEFISEATDRNEQLRSSVADVREKRNLRATITSQELQALQSLEAESNEGAETNDKTLETILWYEKFLGFRIVVGKDVKFVFNKIPQRREKEYSFRVSRSLQLIECDPHVKDIEELAKDLDLNEHLFKFARMAREKFQSSFMNGTLPGTPETLPVSNRSEDAHNETQSSSKKNVQLLPVKKEDTALLGASPGVRRRSKRLKGMR