lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFAQPYMGEAHVQSAPEVNPIKPDQKTEETKAVCHDWPFALLFVLNVGVIIALTALWGVKTVTDPDNNSSELLSGDDTKVVVAIAVGMAVVSMVLALLMVKLIVAYARVMILFVLWFNVGISFALAAYGFIIGNIFIAIIGLIIALLNLCYARAVQHRIPFAVANLRVAEGAIAKHSSTYLVSIVFTVVQIVWVVVWAMALLGVANKIAEDNPSSTTTANTNTTTSTRSTYKQSGESYVAYFFLLLSFYWGLQVFKNIAHTTVAGTVASFWYQSESKGATGGALKRSTTTSFGSICFGSLIVAFLQALRALAESGRQDGSALACFAECILGCLQSLMEYFNRWAYVYVGIYGYKFTQAGKAVFQLFKERGFDAIINDDLIGNVLGFAALGVGLICAGVGALIAETTDVVSFQNSTAFLAILGLVVGIGVAVTPLAVIDSSVATIFVCFAEDPAAFQRSHPELYAPLVQEWHNLYPEIMVQAGYWYA
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MSKEQKDLKKKGKGGGAICMSREVRSLLLLVFCVQRDQDGAFLWVCISSTTSPTQQGMVDDQFRQLQSLQEDGGSTSGFVAEVATLFIDDADRIINDIGSLLDAGGT
The following text describes a protein:
Function:
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMNNSSGDEQVECPLCMEPLEVDDLNFYPCTCGYQICRFCWHRIRTDENELCPACRKAYPENPADFTPLSQEQIAAFKAEKRQRDQQRRAKISENRKHLANVRVVQKNLVFVVGLPPRLADPEILKKHEYFGKYGKIHKVVINPSTTYAGVQGPSASAYVTYINNNDALRAIQSVNNIMIDGRLIKTSLGTTKYCSHFMKNQTCPKPDCMYLHELGDQEASFTKEEMHQGKHQEYEKRLHDAMQAQLGLTSAAGGHGSNGSGSAAATAATAASSGGGTATAAPTAGLVSSTAAAVVAASATTAAAAVAAGTTAGASSTLVVNGGSAGSAGSGGGSGESGVPRSGGSSTSSSNGGSNGGKGTSKTSPGSDIKQISDITNGPIPSKEAWPSLSTTPVGGSAHGGGSSNKENKLNGKTGVAGNKENSNRSDRKHETKSRSKGGKNKQQQQQQQQQHNNKNSHDNSSNHKDSTSNVTSANGVVAAAKGGSAALVNGKGSKASNGKQQQRNGASNAPEAHEHAIVNGNSKEAQNNSKNLKQQQREREREQREQQSLLKGSSDSGEQQQQQKQQQPPQSKKREANGTSNGPTATSISNGNANGNGHIINNDLDDDDDELDFEDLDNDALSSDNDGKTDSPSLSSSASSRNGVDSETASGKSTPGAFVDTLNNGDSNVIDAGASVGDAVASKTDACETNAIPAASDGDAADSNRSSSSPSSSSSMGDEKADSESTAPVASSSSTTTSLYGGLDDGTDTTAAVISATMGKLSVTDTTASNGGIMNHKFANELIDLSARYGKLESILDDNSSFFSYNTFDPYGKPSAAGSTDLGVDSVSGNQSVGLTSSQLPDLLSGTNDTNEQHAKELLKNMGNLQQQQQQQQQHQQHHQLQQHQHQQHLLQQVARFQQQLSAGLIGNGDSSMIGGAGDELDPALTKCLLRQKYMVEDQQEEWLRLHQQQQQQQQQLQQQQQQEQQKRNHLNNGLNGLPPFHNFNEFGTNDFWHKTYAMRNNFLSQQQQQQQQQQQQHQQQQRLHTDMSQMYGNANMSKLNKFFDFHKNQQQQQQQQQQQQFLLNGQNSLPQQALDMNLLALENSRLNNHFLDQHNENLLSSQQLHKQRLLNLGAHNPLLNGGDRSMPQHKASVAAAAAAAASQSQQSGSRTQSQPQSQYPQNPTADDDLGFDPFLETQKALAELMNDEMNQQQLPQSGSNHSKVLENVQQQQQQQQQQQQQQQQQQHQQQHQQQQRTRMPPPGFNHMNAFGFGVPRAQGSKILPFMNGGMQMPNGQQPQQPPQNGNWNQQVQQPFLGYQQNEHMAQPQNGLNKAAYGNNLTDWTSMDPAIVSYRQFSFMNGPNQPAGGDLFLNAQQQQQQQQQMNQQQNLQPGQGFGHHGLNLQSNLMGQQQQQQQQQQQQANPQLNFSHVNIINNERNVFMYEVANCGFPNGFDKYSIPMPPGFQNNVPGNNKQKTECIN
The following text describes a protein:
Function:
Acts as a non-catalytic accessory component of a dynein complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTSPPPSKKVVIKASDIPEHMQQEAINVAISALEKHKILRDVAAFIKTEFDRKYSPTWHCVVGRSFGSYVTYETRRFTYFYVGPAAVLLFKAG
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVKFAQQLQAELVPEWQEAYCSYGELKADLKRIQKHRAMGPTYTRTGSLGLLKSLASMKPSISGIGRTLSRRRVADHISFSPKGTTEDSIVINKRQTQDGDIYITELREPLSHSPQDVTFFTRLDDQLNKVNKFYKKKEAEYIDRAGALEKQMLALINVQELFARQGLSLPSYLPKKEDPVPEVKKASDKEPLMSENSLKSNEYPLQTFPMKPSTFDEKGSSIPEEEAEGDNAIQDYIEQVATKNLKQRRAAFSDVNMELQKPVLHGQDTGFVVPGQLSPATVRHSPVTPMGSSLPPTPKSALKKVSQIPEQKEPETEPVILDNDLENQRVQSFKSQKELDQAKNTLRLAFVEFYRGLGLLSNYRSLNIKAFVKILKKYDKTTGLHFAPIYMKEVESSYLVISSKVQKLINKVEDIFTNHFSDGVRKKAMSQLRPMRKQGTHRTTFFIGLFTGCSIALCISFFFLVDNKRALNPGGSTTAKYLETVFPVFSTLMLITFHIYMYAIDVFAWAKTRVNYPFIFGFSPGTELRYREVLLLATGFTTFLLGGMNLHIAVTLLNSKATPANPGASVDKTESVADIIPLILVLSTLVTLFLPFNIMYRSARVFFLGCFRRLVSAPFVTVLLSDFFLGDQLTSQVLVFRNFQFISCYYPTGYFLTGSDNKCDLNPIYRGFGYIVASLPFWWRFLQCLKRWNVDRDSHQLQNAGKYMSAIVALLLRQAFGNHPQITALWVLSLIASVVATIYASYWDFYVDWGLLNKKSKNKWLRDKLILKNKSTYFVAIGANCFLRLSWMLSILQVDMKFGWNSNAFNVSTATLEILRRGIWNFFRIENEHLNNVGKYRAVKAVPLPFSDD
The following text describes a protein:
Function:
Promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. Does not bind to either buccal cells or non-differentiated keratinocytes. Promotes cellular aggregation leading to biofilm formation.
Miscellaneous:
MISCELLANEOUS: Produced during infection of the human host. Does not bind to immobilized fibrinogen, fibronectin, IgG, human epidermal keratin, collagen, vWF, laminin, heparan sulfate and submaxillary mucin; MISCELLANEOUS: When sasG is expressed at high levels, it inhibits adhesion of S.aureus to the ligands fibrinogen, fibronectin, cytokeratin 10 and IgG. This inhibitory effect depends on the number of G5 repeats present in the protein, since shorter variants do not present this phenotype; MISCELLANEOUS: Biofilm formation is ica-independent, relying only on the level of expression of the protein and the number of G5 repeats.
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A.
Sequence:
MRDKKGPVNKRVDFLSNKLNKYSIRKFTVGTASILIGSLMYLGTQQEAEAAENNIENPTTLKDNVQSKEVKIEEVTNKDTAPQGVEAKSEVTSNKDTIEHEPSVKAEDISKKEDTPKEVADVAEVQPKSSVTHNAETPKVRKARSVDEGSFDITRDSKNVVESTPITIQGKEHFEGYGSVDIQKKPTDLGVSEVTRFNVGNESNGLIGALQLKNKIDFSKDFNFKVRVANNHQSNTTGADGWGFLFSKGNAEEYLTNGGILGDKGLVNSGGFKIDTGYIYTSSMDKTEKQAGQGYRGYGAFVKNDSSGNSQMVGENIDKSKTNFLNYADNSTNTSDGKFHGQRLNDVILTYVASTGKMRAEYAGKTWETSITDLGLSKNQAYNFLITSSQRWGLNQGINANGWMRTDLKGSEFTFTPEAPKTITELEKKVEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGVIISKGEPKEEITKDPINELTEYGPETIAPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGVIISKGEPKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPVNELTEFGGEKIPQGHKDIFDPNLPTDQTEKVPGKPGIKNPDTGKVIEEPVDDVIKHGPKTGTPETKTVEIPFETKREFNPKLQPGEERVKQEGQPGSKTITTPITVNPLTGEKVGEGQPTEEITKQPVDKIVEFGGEKPKDPKGPENPEKPSRPTHPSGPVNPNNPGLSKDRAKPNGPVHSMDKNDKVKKSKIAKESVANQEKKRAELPKTGLESTQKGLIFSSIIGIAGLMLLARRRKN
The following text describes a protein:
Function:
Transcription factor (By similarity). Required for mesodermal induction, acting redundantly with transcription factor tbx-38. Together with tbx-38, acts by inducing cell fates in the AB lineage, thereby playing a role in development of the anterior pharynx.
Subcellular Localization:
Nucleus.
Sequence:
MYSCTSPSGIEVSLNKPEIWEKFYPKTEMIVTRKRGRVIFPHLDYNVKGLDPDSLYSIYIHLERVDGIKYKFDAGEWKEAGKGDPILPIQYKEHPRGKRTGTEWMSEPVSFAHLKITNDPENKDQKLILAQSLHKYIPVLHIKQLDPYKGTFQMDFHGVEFRLEATQFIVVTAYQNEELTKLKVHHNKFASGFRSNGKRRLSSESENSENSPPKRSASAISSLTPPAISPPMDYTQQNPYFFNQNFFSTPQSHQPQFAAHSANAQNYNNFGAQNGAQFDWNVYYQRQWYWQQQMMMSGGIGQPQMLNNGFPNL
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MAGALQYLESQRDAQPELADWYNALADLYQRKLWHQLTVKLEQFVALAVVQAGDVLIQLYHNFIMEFETKINLLKLAHFAGVISRQYSEKEAAISYLEGIIEKLRATKELRIEEPILYVKMQIAAFNLEKGSQKECKKLLEEGKSMLDSMTDVDPSVHASYYWISSQYHKSRQEFAEFYKSALLYLAYTSVESLSAPFRLDLAFDLSLSALLGDNIYNFGELLAHPIINILIGTKVEWLYHILQAFNSGNLVRYQELCRIHNAELSAQPAFLQNERKLLEKINILCLMEIIFSRPSEDRTIPLSIIAEQTKLSIEDVEYLLMKALSVHLIEGIIDQVEGTVYVSWVQPRVLGITQIKSLHDRLDGWVQKVRTALSTVEAETPDLVGS
The following text describes a protein:
Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
Miscellaneous:
MISCELLANEOUS: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRGARGAWDFLCVLLLLLRVQTGSSQPSASPGEWSLPSIHPATSELIVSAGDEIRLLCTDPGFVKWTFETLGQSSEITHNEWITEKAEATNTGNYTCTNGGGLSSSIYVFVRDPAKLFLVDLPLYGKEDHDTLVRCPLTDPEVTNYSLRGCEGKPLPKDLTFVTDPKAGITIRNVKREYHRLCLHCSADRKGKSVLSKKFTLKVRAAIRAVPVVSVSKASHLLREGEEFSVMCLIKDVSSSVDSMWIKENSPQTNAQPQSNSWHQGDFNFVRQERLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVAKGFINIFPMMNTTIFVNDGENVDLIVEYEAYPKPEHQRWVYMNRTLTDKWEDYPKSDNESNIRYVSELHLTRLKGNEGGTYTFQVSNSDVNSSVTLNVYVNTKPEILTHESLVSGILQCLVAGFPEPTVDWYFCPGAEQRCPVPVGPLDVQMQNSSVSPSGKLVVQSSIDYSAFKHNGTVECRASNNVGKTSAFFNFAFKGNSKEQMHPHTLFTPLLIGFVIAAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEVALYKNLLQSKESSCNDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISDSTNHIYSNLANCSPNRERPTAVDHCVRINSVGSSTSSTQPLLVHEDA
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase which may be involved in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MTSKVDTGGWNKLENKLSDSTLNTINRLGFKSMSPVQSAVIPLFMSNKDVLVEACTGSGKTLAFVIPIIEKILKRETNLKKTDIASIIISPTRELAIQIQQVLLEFLNDLNRIDDQNDLENIKTLEDELLEEQEEEENEKEEEEIEKKKKKKKIEISSLLLIGGTDIYQDLVNYKNYGGNILIGTPGRTDEFLTRVVRNDQQFKFKEFEMLILDEADRLLDMGFHLPINSILLKLPKQRRTGLFSATQTSEVKELARTGMRNPFKVSVSVKHIETHEDQSIPTTLDNRYMIVPVEERLNQLVHFLLNHIDKNKIIIYFLTCSTVDYFFKILQSVKVLSGKPFFSLHGKAPHSQRIKVFDSFSQATNGCLLSTDLAARGLDIPNVDWVLQYDSPQDPKAFVHRIGRTARMGRDGNALIFLSPEEDSYIEFLKIKKVPLVEMVKAENVTNVLPEIKKISFNDREIMEKGVIAMVSHVRGYKEHLCPYIFVFHRLNIGLLATGFGLLYLPRMPEIRDKTLIAEWTSGYTKDQILKIAYKEKKKEKQRLEKVNKIKLKKEKDAKERQDAINEKKRKLEQQEADKLLQKQQPKQSSIEIQLKKQEEKKKQEQESINEILHETQAFKKARKSKQQKKDKSSRFSDLMGSDTEQNNNEDEEDEEEEDEDN
The following text describes a protein:
Function:
Facilitative glucose transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRALRRLIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSCVVIERVGRRVLLIGGYSLMTCWGSIFTVALCLQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLILVGLGFPFIMEALSHFLYVPFLGVCVCGAIYTGLFLPETKGKTFQEISKELHRLNFPRRAQGPTWRSLEVIQSTEL
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
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
The following text describes a protein:
Function:
Regulates the dynamic behavior of MamK filaments; paralog LimJ also promotes MamK turnover. At least one other protein besides MamJ and LimJ is required for MamK turnover. May connect magnetosomes to MamK filaments (Probable). Moves from the cell poles towards midcell; movement does not depend on the treadmilling ability of MamK, suggesting MamJ associates and disassociates continuously from the MamK filament (By similarity).
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 20 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Magnetosome. Note=Tagged protein extends in a line from one pole to the other, and is longer than the magnetosome chain.
Domain:
The center of the protein encodes 8.6 repetitions of a Glu-rich sequence.
Sequence:
MANNRRDRDKGDGSQGEGLSAGGGMPSEPEIVSVTVHPTPTLAVSLKPAQQGDIWASLLESSPWSANHGGRIEPVQPSPAPTRPTESPSVGDLVSRWSQPIWRTPSRVEEVETPESNFVIELEASQPITSDITVSVSDLVIEVQPIQTTEAEPEPELPVAEPEPGVVPVDVVAEAEPEPELPVAEPEPGVVPVDVVAEAEPEPELPVAEPEPEVVPVDVVAEAEPEPELPVAEPEPEVVPVDVVAEAEPEPELPVAEPEPEVVPVDVVAEAEPEPELPVAAPEPEVLPVEVVAEAEPEPELPVAAPEPEVLPVEVVAEAEPEPELPVAAPEPEVVPVDVVAEAEPEPELPVAEPELVHEAAVSEPVAESIEDAVAVPAPATNFGLAELMQAAAAMAPVLASPPSVAPAAKPVREPAKKRKAPPVRKKVATVQDVPVEDLLGGIFGIAGSAVRSVLSLGAGVVGGVVKGGRVIGDNVVAGARRLTGSAEGSCGTCSTSQCDTVGKKK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MPKEPKVTGLSPNEGPPGTKVTIRGENLGTGATDLTGLTICGVNCLLTAEWVSPSKITCKTGLCKGKGEVIVTTRSGGLGTCTVTFRGYVMQTGPLEESAVWIDESTTTDKRGRSKSSSALFRKNEDPLGMSMEGKGKFPIDQLEEMFPEGSGDPSNEKFLSEWFLIENHHHTSFDDLKTGLSYLKRKSSQRSEGPLAFMKGNLTSIMDCQDALAAQQGQWMKATSAQDPMHQDLLKDESTSEGGSITEKLETLLNNANDKANAMYQDVLGRKDKADATRNALNVLQRFRFLFSLPGSIERNIQNGDYDIVINDYAKAKSLFADTEVQVFKRVYLEVEKQIETFRGQLTEKLMQLPSSLDEQSKLIRYLMDLGEPGDPAWDCLVNQQKWLLQLLFSCKEEHIKQAQTIPSVAGSEGDTPSSHTPLKYRPSVGTPGSVFTPGHSSVKRMPSFGSTQSPDQAGWKFKTPQRVQFVDDLTDVLLENFPDLWKLWEGYSTGSLLNEAAEKTDVANQEKESKFKKMVEEVMSVYSKLLRAAFLPETLSSLPKEQRAKYGVWPEGKYDNMAHWLPQFVRTIRSCNSTLSGMNLPDETTHDVRDVAQDTRVHCVTTLLQQATEDVKALNDRETWTVERDDRGGITALPLLFENIITELIQHLKEVVQSRAEESEIFRRADTRMKVSKLCEDMLSAFADTMDQLAFRTESQAEAIPTSQQSSSGHNELTSPSEHIPPMERRLVTVLSNCSHTREKVLPKLIDLLEKNGYPEVQKVQKGCQSCFSALDEKLFDAYLEQKADPLVGALEPGVYAGYFMWNDCLPPRGVRNYVKEALMNLIAVHAEVFSISPLLVERVLSRLLQALAEEMLRLMECVTGWSADGAIQARLELCALQDALALYKTPESSKSFHDALQMVPPVKSAADRKNLEELMNKFKSNMQLQLTCFRSDSLKRTLV
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
Sequence:
MSSTRIDTETLRRLPKAVLHDHLDGGLRPATVVELARSVGHTLPTTDPDELAAWYYEAANSGDLVRYIATFEHTLAVMQNREGLLRAAEEYVLDLAADGVVYGEVRYAPELNTRGGLSMREVVETVQEGLATGMAKAAAAGTPVRVGTLLCGMRMFDRVREAADLAVAFRDAGVVGFDIAGAEDGFPPADHLDAFEHLRRENVPFTIHAGEAHGLPSIHQALQVCGAQRIGHGVRITDDIPDLAAGKLGRLAAWVRDRRIALEMCPTSNLQTGAATSIAEHPITALKDLGFRVTLNTDNRLVSGTTMTREMSLLVEQAGWSVEDLRTVTVNALKSAFVPFDERTALIEDVVLPAYASVL
The following text describes a protein:
Function:
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes.
Subcellular Localization:
Nucleus. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase (By similarity). Localizes to sites of DNA damage (By similarity).
Domain:
The bromo domain mediates the specific interaction with acetylated histones.
Sequence:
MAPLLGRRPFPLVKPLSEAATGEGEEEVYMIEHSKEAFRSREEYESRLERYAERIWTCKSTGSSQLTHKEAWDEEQEVAELLKEEFPVWYEKQVLEMVHHNTISLDKLVDQSWMEIMTKYADGEECDFEVGPEKYLRAKIVKVHPLEKEEQASEKKSEGSCDSPSSDKENSNKVAQDIQLKEESNRLESLSSLRESDRARRSPRKLPTSLKKEEKKWVPPKFLPHKYDVKLLNEDKVISFVPVDSLYRSERPPNKEILRYFIRHNALRIGTGENAPWVVEDELVKKYTLPSKFSDFLLDPHKYMTLNPSSATKRKSLGSPDQKPAKKSKKSPLSPSSWSLANLKKTAVNSSSSEEEMQLMIGANLNKKGSIGKKSDKKKPKNGKSQVLNGQKISAKTRSPKKGLKSPKLKQMTLLDMAKSTPKVSRAQKGGSNTPRSSSKPNKYLPPAALHLISYYRDNKNREDRKSALSALISKVARMLSAEDRKRLPDDLQELVQKRYELLEHRKQWAVMTEEQREEYMRKKREALKARIKEKTRERKQKEREERLEKQKRYEDQDLTGKSLPTFKLVDTPEGLPNALFGDVAMVIEFLSGYSDLLLPDGQYPVTAVSLMEALAAEKGGFMYLNRGLVVLLQTLLQDEIAEDYGELGMKLSEIPLTLHSASELVRLCLRKSDSPAGENESIEKGDEDSEGSAVYQDDEVEDEYLEKLETSEFFELTTEEKLHILAALCHRILMTYSVQDHVDAKQQRSGELWKERLAILKGENDKKRAAKQKRKEQGTVKPKEEVQAAKIVKKQEKINTQQDNDAEDMISAVKSRRLQAMQAKKEKEEHEKLTKERIERETEEERSRKQKASAEKAFHEGIAKAKLVLRRSPLGTDRNHNRYWLFSDEVPGLYIEKGWVHDSINYRFSPESKQDSEQDAEESEDANSSIGCPDDSTQREEKHAETTVPKQGQNLWFLCDTQKELDELLDSLHPQGFRESQLKERLQNRYQDIMHSIHLARKQNLGLKTCDGQQELLNFLRSDIIEVATRLQKGGLGYLDDTTEFEAKVRTFENLKDFGECIVFLQAAVIKKFLQGFMAPKQKKRKHQSEEAAAKAEEQDEEKKMAEEAKVASAVEKWKVAIRDAQTFSRMHVLLGMLDACIKWDMSSENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPVLFNIPDGEWLCPACQPATARRSSRGRNYAEDSTQDEDEEEEEEESEEEEEEESDEEEEEQEMMGQRLRSRKAAKGKPGRPTRRGRPPKNNTHSRVSRQRYVEDTEADVEEMVRQSKPTSRRQNQEFQKCEEILAKLIKYRFSWPFREPFNADEIEDYTKVVTTPMDFQTMQSKCSCGSYQTVQEFLNDLKLVFGNTELYYEAGSSQLSCLEKTEQCARDLLGKHLPAHTYQRRHRKHQSPEPEPETANPGRGRKQKK
The following text describes a protein:
Function:
Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
Miscellaneous:
MISCELLANEOUS: Unlike the carbohydrate-specific transporters of the PTS, the complex DhaKLM has no transport activity.
Domain:
Consists of three domains. The N-terminal dimerization domain has the same fold as the IIA domain of the mannose transporter of the bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS). The middle domain is similar to HPr and the C-terminus is similar to the N-terminal domain of enzyme I (EI) of the PTS. The IIA domain of DhaM (via phospho-His-9), instead of ATP, is the phosphoryl donor to dihydroxyacetone (Dha). The phosphoryl flow likely involves HPr ('His-15') -> DhaM (His-430 -> His-169 -> His-9) -> DhaL-ADP -> Dha. The HPr-like domain of DhaM cannot efficiently substitute for the general carrier protein HPr.
Sequence:
MVNLVIVSHSSRLGEGVGELARQMLMSDSCKIAIAAGIDDPQNPIGTDAVKVMEAIESVADADHVLVMMDMGSALLSAETALELLAPEIAAKVRLCAAPLVEGTLAATVSAASGADIDKVIFDAMHALEAKREQLGLPSSDTEISDTCPAYDEEARSLAVVIKNRNGLHVRPASRLVYTLSTFNADMLLEKNGKCVTPESINQIALLQVRYNDTLRLIAKGPEAEEALIAFRQLAEDNFGETEEVAPPTLRPVPPVSGKAFYYQPVLCTVQAKSTLTVEEEQDRLRQAIDFTLLDLMTLTAKAEASGLDDIAAIFSGHHTLLDDPELLAAASELLQHEHCTAEYAWQQVLKELSQQYQQLDDEYLQARYIDVDDLLHRTLVHLTQTKEELPQFNSPTILLAENIYPSTVLQLDPAVVKGICLSAGSPVSHSALIARELGIGWICQQGEKLYAIQPEETLTLDVKTQRFNRQG
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEGGGDDDGGRSRAEAIMRELERLRAEREELDGRIRLLESQLRLGAAPLPPSAAAEVEPTGSPSSSSSAAADMISRYRRHLLLPQFGLEGQRKLSQSSILVVGAGGLGSPVAMYLAACGVGCLGIVDGDRVELDNLHRQIIHIEAYVGQPKVKSTAASCRAYDIVVDATNNLPSRYMISDCCVLMNKPLISGSAVGLEGQLTVYHHNGSPCYRCLYPNPPSSPTSQSCSDNGILGILPGVIGCLQALEAIKVATAVGKPLCGRMLHFDALSSHTRIVKISRSSPTCKVCGENPVFTKEDFVNFDYESFTQSPMSKNSTTRSLNLLPENARVSCRDYKKVLDSGRPHLLVDVRPSHHFQIASMAHSINVPLSLLEEKLPLLRDSAREVSSRRDGRQHCPVYVICRRGNDSQVAVQILRENGFLYASDVAGGFESWAKEVDPSFLLY
The following text describes a protein:
Function:
Probably involved in translation.
Sequence:
MKLFDRLKVDGDDDEADKGGTITVGIFWNVTIARRKEGIGRRIRFLDGGLTEEKKVRLSGIRRSDERKQEEDMDAAIEVDLKLRDRRRWMNVYTKSNHNPQLSNKAMNLGAQTGDIGFDYYAAEPEIHFFSAIPEEDSISKDDLEKKLDPSVFKIGSTQAAKKRWVAMGKQVSRKVQHVEDKVKESLLQIQQGLWLDRERLCWFAVNIGANRWLSLKRSDYLPRTCRRIYKFTSAMLDAGLKSQKWGWTGYSDVEKGPNYASKRKIFATDLTRENLHNWQELEFKEYNFNAKGQPLHASYLHPLLKVSDSLSFCPSDQQSFMSELDSQVPTAFDPFADANAEDSGAGTKEYVHIRVQQRNGRKSLTTVQGLKKEYIYSNILKDLKKEFCCNGTEVQDSELGQIVCSIFLTCATAKCFLTSSVFTCDIHIYLLVLKWVLAHA
The following text describes a protein:
Function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRVMLSQLSSVLNARLIGEDRAVSAVSTDSRAIPAEALFVALVGERFDAHDFASQAVTGGAVALLVERELDAECSQLVVADTKQALGQLGSWVHAQCQTPTVAITGSCGKTTVKEMVASILSQKGQVLYTQGNFNNDIGVPLTLLRSTTEDDYAVIELGANHVGEIAYTTALVKPDVALVNNVAAAHLEGFGSMDGVKRAKGEIYQGLQAGAVAIVNLDSNGGDYWKAVLADKTVKTFSATDHNADFYPRDVRLNALGIASFTLVTPVGEVGVELGIMGQHNVANALAAAALSLEMGASLAEIGQGLAHLSKVKGRVDMAQLRDDITLIDDSYNASVPAMKAAVELLGSFSAVRWLILGNMAELGDESLALHQQVGEHAAPFGFEFVLTYGKDAKVISDLCQGHHFATHQDMMTFIEQHIEQQQGRTQVLLVKGANSAGMSKIAAALKEKFA