lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAQRKLQADIDRVLKLVQQGVTLFEETFDKMTHATNQTSKDKAEADLKTSIKKLQRQRDQIKTWLQSNDIKDKSALMEHRKLIETQMERFKACEKEMKTKAFSKEGLSAQQKLDPKEVAKMEMSHWVSTMVDELGQQIERTEAEVELLRSQTKKKKPTSGSDGRSSELEALNDRRRWHIGKLELIMRLLENGQISPERVGEVKDDIQYYVESNVEEDFTEDDDLYESLNLQEEEEHYGLHDDLLSSHDTSSIIEDSNLSGEKSPVKEKMSISGAQILRGPSVRKPTMESGTVRPAIVSGRTGVVTGMVLPTGSAPRTTPAPLPSLRYASAAAAAASSNVTTTPSVPSSAKSPGPVPAVPQRSNSLSLSGTTPGSLPAQPSAESPKKQPQQIPHRPFAAVASPDTKVAALPGSGVSRPMLSGSDPSSTSQDLISQSADGGSSSSLVHNPSGQSTQSGQSSQSAAEPSPHPITDRSPSPSNSQKSRQSPPQADGGAMESVPNSGEIKPTGSTSQASDRRGSEIMTGEEKLEDGKRASLQVNNNGREVEGGQTSNPSQENKSVSSLADLVETYEHLKAHTPSMAEMQKVIETGISGLPQIQDAEKPYYYAPRNPYPTSSHYPQQPMAFEKRPAIWSEIEVEVLFYLFYYHQGGYLQYLAAKELKKRAWRFHKYYLTWFQRAKNPEEMADDYEKGSYTYFDWEADWLMRTKTPFQFDYKHLEDSL
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MRHYEIVFMVHPDQSEQVPGMIERYTAAITGAEGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEASPMVKAKDERRERRDDFANETADDAEAGDSEEEEEE
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MDLAIQPLSFALTFFINSSLIYLIVTKSPKIMGTYRHLMIYFCCFSIFFSIIDVIVQPTMFTYGSGYFMIIDVKKRGIPPEVAVFFMKVLCGCFGVTIYGIAIHFVYRFFALERKGKLKYFEINYLALWFVIPVVGGFSWYITIEIFFESGSGSLETEYLRNMFNKSNLNFADFASIGGVYYSTNNSVNWRSISGYSCFVSIMVIAFIIIVVAGWKSWKIVSKLLEHGESDFSRKLQMQLYKALVAQTTVPIILLFIPFGILFTLPIFKLGCQFLNRIIVLIFAFYPAIDPLPIIYFVDYYMVSVLGKTLKTILITFRSFQMQNESKSCNS
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MEPPQPSSPSSKPCDECKTNEFKYKCPGCSVRSCSLPCVKAHKQRTGCTGKRQQLTEFVPLSKFDDNLLLSDYNMLEDVKRIADSAKRRRVSLCGSDYGIPLHLKSLINGARSRRFKLFFLPTGMSKRQTNKTSFNNRWKVFYWTIEWRFHSTDIKLIDHGVNENSNLCSVIQKHLKPGPTNHPLKPFYLEPVESLKFYISKYPKNPRSPVRELDINAPIRKQLDNLVIIEYPVIHVFLPSHSPDVQVLKPIVSQQVQPKTDPVNDSQPDVDPKGVFFKEEVIKDHDSEEPLVLDLTDKSNSKTETKDDGANVIDKSLVNDSQPDVGPKGVFFKEEEIKDHDSAEPRVLDLMDKSNSKTETRDEGANVIDKSPVNDSQPDVDPKGVFFKKEEIKDHDSADRPDVDPKGVFFKEEEVKDHNSAEPHVLDLTDKSNSKTETKDEGANVIDKSLDSTCNDNVLSDLMNFDFEPELVDVYSSLISETNPDDFLDFDGLCDDLPSKEDSKLGDIEEELEEGEIADSD
The following text describes a protein:
Function:
Involved in copper resistance.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MMLTFVWITLRFIHFASVMLVYGCALYGAWLAPASIRRLMTRRFLHLQQHAAAWSVISAAFMLAVQGGLMGGGWPDVFFVSVWGAVLQTRFGAVWIWQIILALVTLAVVVIAPVKMQRRLLILTVAQFILLAGVGHATMRDGVAGTLQQINHALHLLCAAAWFGGLLPVVYCMRMAQGRWRQHAISAMMRFSRYGHFFVAGVLLTGIGNTLFITGFTAIWQTTYGQLLLLKCALVVLMVAIALTNRYVLVPRMRQENPRTDLWFVRMTQIEWGVGGIVLAIVSLFATLEPF
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system.
Sequence:
MWLADLDPTRGREQAGRRPCLVVSADPLNRGPAQLVVVLPITSRDKGIPFHVGLEPPEGGVTVRSFIKCEDVRSISTQRLTEKWGAVRNETLLAVEDRLRILLSL
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSAANGIRHMKQHKRQVLNLYKRVLRVNKQLPKEFRLVGNAYVRDEFKRHKTMAMDEGNVKEFLSEWKMYADHLEVQLKQNHAIGSNLSSQDLNRLSEDQLGQLYHLQEEVYKEIFNSITSIEYQLYWL
The following text describes a protein:
Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MVHETRSRTHATEEGKTAPKKQKEEHKEQEGGQERPSKNKKPVEPEAETKTKKHKGGESELDGKENTTKEYTDFCKAIREHLPAEDMRKILEANGQDASGSEDAVVSSCEDMMFYGPLEKCPICGGQLECKGWKYKCTGKYSEWASCIFSSNSPPRKSDPIKVPEDVSNDFLNKWLKQQEGKGYPKRDVDEEAHIFSGMMVALSGRMSRSHAYFKEQILNHGGQVNNSVLGVTCVVASPAERDKGGSGGFAEALERGTPVVSENWIVDSIQKKEAQPLAAYDIVSDVVPEGRGLPLDKLDPSEEAIETLAAELKLAGKRSVHKDSKLDKDGGCIFEKDGIIYNCACSICDLGSETNQLCIMQLIMLPEEHLHLFYKKGPIGHDQMAEERVEDFGIRVNDAIKEFARLFKEVTGNDFEPWEREKKFEKKSMKMYPLDMDVGFDVRHGGAALRQLGAAAAHCKLDPAISFLLKQLCGQEIYRYALTEMAQDLPDLPIGMLTDVHLKRGEEVLLEWIRDAEPAPESRLAADAFWIEISNKWFTLFPTTRPYIMRGFEQIADNVASGFETIRDINDASHLIGDAFASTLDDPLSECYKKLGCSINSVPEDSEDYKMIVKYLEKTYEPVKVDDVVYGVSVDRIYAVESSAFPSYNEIKKLPNKVLLWCGTRSSNLLRHLHRGFLPAVCHLPVPGYMFGRAIVCSDAAAEAARYGYTAVDRPEGYLVLAVASLGEEIKEITGTPGAEDVKSLEEKKPGVKGVGRKTTDESEHFTWRDGVKVPCGKLVPSGNEDGPLEYNEFALYDPKQVSIQFLVGVRYEEQNMEVVPDE
The following text describes a protein:
Function:
Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Required for adipocyte cell viability and metabolic homeostasis.
Sequence:
MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFAPVSEMDHTHRRYGHQKLKKNVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL
The following text describes a protein:
Function:
Acts as a regulator of the microfilament network governing cellularization of the embryo. Determines the timing of a key conformational transition in the cortical microfilament network: the proper coordination of membrane invagination and basal closure of the cells. To do this, bnk possibly physically links neighboring contractile units of the early cycle 14 microfilament network in a manner that prevents basal constriction until the proper stage has been reached. Bnk together with nullo and Sry-alpha may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Colocalizes with the structural transitions in the microfilament network during cellularization. Association is observed only when the network assumes an aligned and tightly apposed hexagonal configuration.
Sequence:
MSISTFNFQFYNYKLSPSSPGFGSTASRSSSSCISELEMDIDEDMSAQPTITSTPKPRFTSQLAVELAKTEPGNGISPLRPKLHTAQKRWSMELREKVLEMSKRNNGQEKPQTARQQEQRQPQEQPLQQEELQHQQQEPTVTDKINFFNKLTNTFESGFSKLMPQASSTNNRFIAMLRTARPQNVATTTANSSTANSFLGSDHSLSGSVTGQVPPPKPKRLSATTAQFATPHVPAMGVGKGGSQRKCSLRRKPSMDKSRATISRQSSSASVRTQNHAIMEDLSLVVPVRLRIAEYEQRISMSA
The following text describes a protein:
Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Sequence:
MPVSQDIVKLAIEFPGSGKMAQLVDFDQKKPLVAIIRDVCDVWQVPSSEQYALQYSDNTQTYITEKNRNEIKNGTVLKLTTSPSKTAADIVLCMKGEDSVEKCKALQKLAKISADVTFASEFISRDGVPLLAGMVENGSETGENLAFILTAFLELMDHGVVSWDNLTPTFVKRVATSVNRHSADATILQKSLAILESIALNSYELYSLVSTEVTFGNLISHIQSSNQEIQCNAVALINALFLRAPEVKRKRAHSEADLSDEEECWQRNGSELSITLSDKLNAKQIRNVILNHVIRGPRQVGTEMAHQLYVHQTLSFNLLEERRMTKLDQNDQVLKDQIIELRKVAFDNDQDLSGSIPPPRKTAEKYTRDYKKLGFTNYTNPALDFLETPPGVLALDLMVYFAKYHAESYTKLVLENSCRQDGHECAFGKSSIELTKMLCKILKVGEIPTETGQEYYPMFYTHDHAFEEFFCICIQLLNKTWKEMRATHEDFNKVMDVVRDQIQRALAEKPNSLEGFKTKLQGLSYAQITKMRIQERSNKEEWDSQARPVCELREQIKPEIINLVKQQRLNYLVEGTLFNKFTNRRVKDKFWYCRLSPNHKVLHYGDAEENSNPPIEMLPEKIPISEIKGIVTGKDCPHMKDFRRAKGVTTLAFAVLYDPDQSLDFVAPNETLYSIWTDGINALLDKEMVSEEMKNDVETLLSMDMKLRLLDTENVPIPDKPPDMPPDPPNFDFCYDFS
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. Plays a role during development in processes such as meristem maintenance, leaf morphogenesis and root morphogenesis.
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MPSMAQGELKSFVQNSRPNPKSPTVSPFSMRQKIAEHRRSLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQPVSEKTEFGNVASQVQTTTRDANGPQQNGVLKGYQGRKLSPLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILYTVHPESDYVDATLVTIFQIHFEEKPGDILVFLTGQDEIESVERLVQERLQNIPEDKRKLLPLAIFSALPSEQQMKVFAPAPTGFRKVILATNIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEIKRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLENPVGYQMSRLPLEPVYSKALILANQFNCLEEMLITVAVLSVESIFYDPREKREEARTSKNHFASVEGDHLTYLSVYRESDEFLEKRKAAGSGNNIDKIMKKWCKENYVNSRSLKHARDIYRQIREHVEQIGFNVSSCGNDMLAFRRCLAASFFLKAAQRQLDGTYRALESGEVVHIHPTSVLFRAKPECVIFNELMQTSKKYIKNLTIIDSLWLSELAPHHFQTAE
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MPRRAFRVAYDGRPYHGFQRQPDVSTVAGELFGALRRLDVFDGAKPPGYAAAGRTDAGVSARAQTVAFDAPAWLTPDAFTGALPDPIQVWAHADAPPEFHATHDAVARTYVYYWYAPDSRATDDRAAGALDRLTGTHDFHNLTPNTTNTVRELDATLDRDGAFRVITVRAGGFCRELVRRVVSLVQLVTETGDTDRIDTVLGDEPVAGPDGVPPADPHPLVLHAVAYDGLSFTVDEDAAERARTTFRAARADHHERARVAGHLASI
The following text describes a protein:
Function:
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Sequence:
MKITGKSLGRHILAEMYNCNREILNDVEKIKEIMVRAAIEAGAEVVEVVFHKFSPYGVSGVVVISESHLAIHTWPEYGFAAADLFTCGDHVNPWKAFEYLNNYLQAEQFITFEAKRGILPIEAGNFTYKPESVKEEEKETVG
The following text describes a protein:
Function:
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.
Subcellular Localization:
Secreted, extracellular space. Note=Associated with CD180 at the cell surface.
Sequence:
MNGVAAALLVWILTSPSSSDHGSENGWPKHTACNSGGLEVVYQSCDPLQDFGLSIDQCSKQIQSNLNIRFGIILRQDIRKLFLDITLMAKGSSILNYSYPLCEEDQPKFSFCGRRKGEQIYYAGPVNNPGLDVPQGEYQLLLELYNENRATVACANATVTSS
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions.
Subcellular Localization:
Nucleus.
Sequence:
MSGSFWTSTQRHHWQYTKASLAKERQKLWLLECQLFPQGLNIVMDSKQNGIEQSITKNIPITHRDLHYDKDYNLRIYCYFLIMKLGRRLNIRQYALATAHIYLSRFLIKASVREINLYMLVTTCVYLACKVEECPQYIRTLVSEARTLWPEFIPPDPTKVTEFEFYLLEELESYLIVHHPYQSLKQIVQVLKQPPFQITLSSDDLQNCWSLINDSYINDVHLLYPPHIIAVACLFITISIHGKPTKGSSLASAASEAIRDPKNSSSPVQIAFNRFMAESLVDLEEVMDTIQEQITLYDHWDKYHEQWIKFLLHTLYLRPASAI
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MNQKNYTILNENRIRQLQNNDISIVSTHLFISRGLAFTLLRRNNWSTNSVFDEWFSDEDKVRKSVGLLPAAQESLKPDNYLCKICFDKIEPDVKTLSCGPCSHPFCPDCWKSYVSSSIKDGPGCLSLRCPEPECKAMVGPEFVESLASEEDKDKYYRYLLRSYVEGSQNRKWCPGPTCDLAVQIIDGSENNYEEVNCDCSHRFCWNCKEEPHRPVDCQIVDKWRSENNDTWIRAFTKPCPKCGRNIEKNKGCNHMTCRIPCGHNFCWLCLGPWKHDGTHIYCKEYEDRDQEANTYYAFHYQKWASNHESRETAMKNLRRVKNGLIQNVADFELQFVIEALEQIVESRRVLKWSFAYGYYLPSTETRKIVSLHNLQEEAEAVVEKLQHFYDKEIVKYANINFPSDKLTDFRGKLVDMTNVTRNCIEKLVIKGLVNDVSEAKTYCSLFKVSLVENRPQATKTCDETRTLATKLGLLRRFIFRRNGGPNSSPMVPPQRLRRILYFVVKEATKPLFVAKSRFYIIN
The following text describes a protein:
Function:
Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEEMEKHLGRVNFLVNAAGINRDSLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFIHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL
The following text describes a protein:
Function:
Binds to the cAMP response element and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MNLEQDRSFVCNAPGCSQHFQSEDHLMIHRHKHEMTLKFASIKNDNMLSDQTPTPTRFLKNCEEVGLFNDIDCSLEHEFRSAQEDENSKRSITMHNAAGGMTGPGTHQLSNPRLPNHDTSVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSMSSNIMGMQGPNINNPCASPQVPPMHSEAKMRLKAALSHHPGAISNGNMNSMGHMIDMMNSRQDQTPHHHMHSHPHQHQSLPQHHPYPHQQHQHPPHHPHSQPHHQQGHPHHHSHSHLHAHPSHHQTSPHPPLHTGGQAQLSPAAQQMQPTQTIQPQQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPENSPPESPVPACSQQQVIQHNTITTSSSVSDVVGSSNLNPLANHRTDINPIL
The following text describes a protein:
Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular Localization:
Cell membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein.
Sequence:
MDRSVVPISLAPFQFLLVFWIFLTSVHTNPNKQQKTVVSLSLWWNSKNRIRGCVWFFFLLRVTRTMGQQNLIYSFVARGTVILVEYTEFKGNFTAVAAQCLQKLPSSNNKFTYNCDGHTFNYLVENGFTYCVVAVESVGRQIPMAFLERVKEDFNKRYGGGKATTAQANSLNREFGSKLKEHMQYCVDHPDEISKLAKVKAQVTEVKGVMMENIEKVLDRGEKIELLVDKTENLRSQAQDFRTQGTKIRRKMWFENMKIKLIVLGIIITLILIIILSVCGGFKCT
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. The DASH complex mediates bipolar kinetochore-microtubule attachments and facilitates the formation of additional interactions between outer kinetochore components and spindle microtubules. During chromosome movement along the microtubule, it is required both for the sliding of kinetochores along the lateral side of the microtubule and also for microtubule end-on pulling on the kinetochore. Modulates cytoplasmic microtubule dynamics by tracking the plus-end of shortening microtubules and slowing their depolymerization.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Note=Associates with the mitotic spindle and the kinetochore. In the cytoskeleton, localizes to cortical microtubules.
Sequence:
MRRSTIVPTSRTSSSSPSPSQMKSFQMNRLVDQLSKLQSNMSHLENHLHVTAIQAEAIRRLGALQASLLMASGRVMSEARIQKSSDAVEEDVPM
The following text describes a protein:
Function:
Involved in the balancing of excitation energy between the two photosystems I (PSI) and II (PSII).
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Prevalent in stroma lamellae with low amounts in grana.
Sequence:
MAATFATPSTVIGLGGSSITTKPFSSSFLKPTLSAKNPLRLAGASGGRVTCFERNWLRRDLNVVGFGLIGWLAPSSIPAINGKSLTGLFFDSIGTELAHFPTPPALTSQFWLWLVTWHLGLFLCLTFGQIGFKGRTEDYF
The following text describes a protein:
Function:
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endomembrane system. Membrane; Multi-pass membrane protein.
Sequence:
MVTLSGDLAATSASTAGTILLLNIVGICMAVFPLRPAPEESGIVSKEGIRVASQIAARILMPCLSFINVAELQDISSIWPVSIWHLVSIPFCILVSYMLSFLFRVPNELRAIFVAAASFSNLASLAYVIMQTLCEQPELDVEDECYDRAAGFIAISIIPWHLLFWTAGDYTLSLAARAGTDYTPKAPLSKEERRAARIKSAVDLLLKILNPNLVATLVGVLVSQVDVLHDLFFVPIGQDSGRPPLSFVTSAVSSLADASVGLTTIIIAATLGKRLLRVNWRKLRARLLCRYQPNVATTHPAKADSPDFIIATSFAALSPDSSPQLNAASSTATTTTTADNDNRATNGGASANNKDAANDDDDDSNNDAIFNDMPSKTDVEMILADKSDPAKLEGNVDAAAILAQARRRKGRLSPTFFLQLIFVRVYLMGGLLFAMVYLISPLVFPDSQPDSSLIRLVFFVQCIVPSANLIVLLAQQRGLVVIAEDIALAMLCQHILSALSSIFFTAIALSIVYDA
The following text describes a protein:
Function:
N-acetyltransferase that may act on a wide range of D-amino acids (By similarity). May also acetylate histones, polyamines like putrescine, spermidine and spermine, and certain other small basic proteins like nuclear HMG proteins (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MGSVRIRSVIKEDLPTVYQFIKELAEFEKCEDQVEATIPNLEVAFGFIDEVTPVAYGVFIEENDQPAGMAIYFLNFSTWTSRVGIYLEDLYVRPQFRGKGYGSYLLSYLARESLRIGGRRLDWVVLDWNQRAIEVYEKAGAQKVGGWSMMRVTGENLKALADKLPGNF
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1.
Sequence:
MAEPLLRKTFSRLRGREKLPRKKSDAKERGRPAQRPEPSPPEPEPQAPEGSQAGAEVPPSPETSRSPARGAYLQSLEPSSRRWVLGGAKPPEEAALGPRAPGSGEPAGEIWYNPIPEEDSRPLAPEPPGPQPGSAEPEGPASQGAAPASPPTKTSRTKSPGPARRLSMKMKKLPDLRRRLSLRGTRAGRERERAAPEGSVISRYHLDSSVGTPGRAAGAGATRGPRAGYLSDGDSPERPAGPPSPTAFRPYEVGPTARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGVARARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGLLYAKLTLSEQQEAPGTDEPRVFGLPLPLLVEREQPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYQVVLEAMAQGPPSRAPSSTEGTRELLNCLPDVERATLTLLLDHLRLVSSFHAHNRMTPQNLAVCFGPVLLPARQAPSRPRIRSSGPGLSNAVDFKRHIEVLHYLLQAWPDPRRPPEPPGLAPYLRPKRQPPLHLPLAGPEVVARPRGRGGPESPPSNRYAGDWSVCGRDFLPCGRDFLSGPDYDHVTGGYSEDEDEEAGEPAGAADFDDDFEAPFNPHLNLKDFDALILDLERELSKQINVCL
The following text describes a protein:
Function:
Binds GTP and GDP. Plays a role in uterine seam cell development.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MANPDVENLFSLCDSESKGFLTMEDLKKVCPQLDDNDLRFIFNELDRDGSGKIEKMEFLQGFQETVQHGESRGLNGMQRRASVAFDDGGPVFRRDELVFESESDSSSRPAIRVYDEEHYHSESDTNINIDFSVPCQEEVLVLYEQLQSSGVPALLRKFERVVGSFHKELSEKKHENERLQRIYASEREMYNRRMEEMESEVDQQLELIEMKARQEERERLTKEKEEMRERMSEEMSEMRTNIERLQRMEKVLERENERLNHQKDLSDKLKVVNEENNDLRQNLAENHLELAMIKSELAQVRADFDQKQDELSARRDQASHATEESESVRKQLQLLFDANRKLHETNESLRDALDSRASVLRQFNLRTPSPGLINSNRNSVENFQTSTNMFKSVPLHAISDEEPDPETSLILDDAHSLQGMDIAEGLVGLNDANGPAERTFRIVMCGDAAVGKSSFVMRVIRRQFTNQLPSTLGVDFHVKTVNVDGRNVALQLWDTAGQERFRSLCKSYFRRADGAILVYDVCAEHSFLRVRDWIETIKESTERSIPIILVGNKVDMRLQTPGAVAKTDGASMAAAMGVLFMETSALDGSNIDNAMLALTRELMAVEDVEIRSTGVVLNPAATKKGGCFSKCRGS
The following text describes a protein:
Function:
Probable Fe(2+)/2-oxoglutarate-dependent dioxygenase involved in oxidative demethylation of nucleic acids. Binds nucleic acids with a preference for ssDNA or ssRNA to other types of DNAs. May play a role in nucleic acid damage repair.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MANLCKRVVDLEKYIVKEAPPTVYYIPDFISEAEEEFLLQQVYRAPKPKWTQLSGRRLQNWGGLPNPKGMLAEKLPDWLLEYTEKISALGAFAGKTANHVLVNEYKPGEGIMPHEDGPLYHPTVTTITVGSHTLLDFYRPVCQAEPDAPQTEESRYMLSLLVQRKSLLILQDDMYKCYLHGIRGVCEDVLSEHVVNISSTGAQVGDTLPRSTRVSLTIRHVPKIIRANLFLGKK
The following text describes a protein:
Function:
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MQSSLARPLGPPIRPGGANPGHRDRPGSVSVSQCRAEAAPPVSVGRTGPYTGRDPEVKKPAWLRQRAAQGEKYARLRESLGELKLNTVCVEAQCPNIGECWNGGGGAGGEGDGIATATIMVLGDTCTRGCRFCAVKTSNKPPPPDPMEPLNTALAVASWGVDYVVLTSVDRDDLPDGGSGHFAQTVRALKELKPGILVECLTSDFRGDLEAVSSLADSGLDVFAHNIETVRSLQRIVRDPRAGYEQSLAVLNHAKSCKENMITKSSIMLGLGETDEEVKQAMIDLRAIGVDILTLGQYLQPTEKHLTVREYVTPEKFQFWKECGESMGFRYVASGPLVRSSYRAGELFVENLIRNKKSKPAPAS