lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTSLSRQLEALSTAASQQLGVEAQHPSLLFEKKEAAGLDRETVHKIGCTGYGQLLKLDNAFELDAKLFDETSMEVQRLLLTRDEANNLNLRIERFLVRLSPYLQQFAAQQALEWLIYKYHIHSYNAEFLIVNFLPFHESNIYGRLIGALNFKFAKSKEWCFMTEYAKKKLHIPFPILLKNALSGTHVLLSQVISHLEKCVELAGESYVENKCPILFAFLAKLLLETLNPKNPIDDSLLSKIIPVIANGIRSKIRSLRYAALMVVCQLSLSTKLTEKTLSAILKLLIMKLRPETLTESISTIIVLTQQQKVESFSSKATCKMLRRDDISSIISTICEVGKKSDLTNFYSALWSTLLEINKDSDCPERGINLFFAGTINDLNGKQASILISLLLNHLSEGAKLPHGIIEEVHPLVARFSDEFHTIRGDWKIKDAKALSTLISVCDLDSLLMIEGTSKKKEEGGESGEKMQVDVPKRINYPDAVAMARKAERTMIAQGTKEKLDGDAVKKCLKWIDKKKWEKLSWALEEMAGERKYIDGKLEEDLEDLFVELMRIGVERPTGLAVDRCRDVMSMIVVRPDMAVDMLTRQEAEGSSAKKKKTVTPTSGPSIAKYFANETDEMWNRRLILGLQVLCLTPKLDASPKLLPLLFSFIASSTTDESTENGDIIHSILQSTVTLLLRLLTTPGAYRILPSDLRMEVVVSTMRTTLSHHLLRDSLRLLTAAVKIAPSSVVSHVLSIFTFMGSGLLKKDNELTLSIMEDTLNALFHAVVTEGKKEEINSRLVSVCKIFAVSINDIPAHRRGRASHSISRAVGSSLIPIVIETFMEGFCAKWQKATGDAAKNFSRGEQEAYEEMACELVSSFPPVDQLAVLLELIVYVIRLGGDTLKKSECQSVLDRSIFDRSSHSLPRLRHYRFLILGVIVRVLCRKNIVDDLASMDDSSLSRLLLPLSHRLLSSSVDLDDFSSNESTKAEQMDGEAAQHAIRYWMAFASRSELVADKLRHLLPGSVAGQLIISILRDTKTDAKLREKALQLANVKLISDGGFSKDGEENDKHLNELATTLNGWIVPARVAEKIVLCQNAAFSLKLIAKNLRPTSDSTVLATTMEACTNTLKEWSTLDESLVGNTLLLSGELIRCHNMRATLMSAPPLMEISCAILAEILATRKAEDGDKSTPASPASSMSSQTAATPVNRRARMRQQSLCGRKLGGDTMVICALTCTQRLLDHLGRFVSSSLSTLLPLLARLAPRFGLVGGKELEAVEKGKDGKGSIEFRLQLIRKALLALDLRLVLCHAMNAAKELRGEQKCLSWILSLLSSSFPLADRSWLSKQNETLLNDLFRPLLEMRSAQRKIEMLESLVSSESEVTECFNAFASMLSETELRPLMASLVEWAGEGLEGDASLPARLRLVSIFHMANGFYSCFNTLSLVYFGRLFEMAAKTLTALNYTKAASPLYSLKKNEVDPSEVHFLILQILQFIQNCAKQTRFFSSDRWKMVVTPLVDELENSKVEGHEARCLALADTLYPALEAHSDTLGDTLQAILVKVRDGKAKLRYRCLLVMERLGLRIGEGLAPHLPLLMPYLSELMEDDNRAVEEQTERVVRVLQKKFGEDISEGFINDSLDLIDTMREAQTTFNLFLNNRFELAEERMITLAHTSVYHAVGLNTIRLIKATMTCEKTALDEAVSTCKSALLLIDGRRMKWSVADTIYSFGEWTKPKAIAASDEELHAELCYAETLMFRSLLTFFQDESLTSFVRGALKIRTCHSIYKSCHKILEWPEVWEHRDKRIKEQFESGVRLGVGCFSLMISCLPPKVLKLLAVVGFTGDKEVGMAELHQCISHSYTLRAHLGALILLTWNLIACYFLGVGEPNLEEARQLIIPFTQRFPNGSLILFLRARLSLVSGNIEDSIRYYNASINSQDSYRQFHHGCFWELIFAHCFLREWHIAAAYAKRLAKESRWSRTIYIYYLSILLSTDNAIERMKRDETVQALLIKVDRYRSRIAGKSIPMEKFCSKRASRGLRIGSLPFANFEFLYFWNAMDVISDKPKLIKPLLSDLMDTWSEVKSEVDVNEACLYRFLRGVLSRHLGLFDEAENCFNDVIHRENQLTELSYLIPNAHYELGVIKQVQSLNDQAENHFNTALRFRSYSLENKLHFRVHGAMRKLGGSRMKSE
The following text describes a protein:
Function:
Involved in transcriptome surveillance. Required for piwi-interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro.
Subcellular Localization:
Cytoplasm. Note=Co-localizes with prg-1 in germline nuage structures called P granules.
Sequence:
MVIVTDSNFLDAAGTLRKGLLYCDFVAIDFEFLGLDVSAISLHDTVESRYQILRDNVIKYRPCQLGLTLFKQKSNRAYKADTYSVPLFQRFGDNDTSISLPSMRFLVKNKFNLNQVFMDGVEFCTRKEFKKFERALLAGTAASYLSREVKSQIELLKVMVHEKCYQSTSYHITHRTDEPMQKIPLKMKPNSSVSLRMPRNLSSVEKYMIIYELTKAFPQFLFTCDEKQQNLHVKNISDDYLKEKDNLERARARCSESVKGVSAILQVVHMTGKLVVGHNSLLDAMYMYHYFFSHLPANYQMFKDKFNALFPRIMDTKLLAQALRFELPGVGDSLENLGDYFGSDKSDKTVPPELRGFIEPWMNPLEDESENVYHNAGFDSYVTGEVFLKLAHIYINRRNNFKNEILDFDRIYQYLEAPILNRLPFQLMDVGCCYLTGDDSKGFRPDVITIVRRDRVAIEEDEFRYLEKALGTLMATYQFDIEWSKNKKELFLATNSPGSYAFLCEKFSNDSSLAPLDELDSGKKWTFEQRQTAWRSFKNRGVGIGINAKRIRAQNQATKIQRAMEI
The following text describes a protein:
Function:
Dephosphorylate DNA's 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSHKLTILPFLIKFTPKFPQSIDHDEHGLNVYAFDLDHTIIKPKSPNISFSRSASDWQFINFNSKKSTLDYLCNIIDNDPTAVIVIFSNQGGVITVPRTSKSCTKYTNKILLFLKAIKNDERGETLSHRLWLYAAPKRPKTFAANHSKITFASLGESYNNDPNIFEKVRKPMTGMVEFFKRDLESAYRVSEQISPIKLNWIYYCGDAAGRKKDFSDSDIKFAENLHVEFKYPEEIFHG
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
KKGLSLLKKTKYSCCLTQSTVFIKRFLFTKPCAKLLGELQYSRVEERWSSYCLSSLTAQNICRGKLSGCRTRLEHSSLSGSAYSTPCCSFLNGLATGSSGLSLPTPVCNPNKAIFTVDGQTTEILVVNDKACKLLGCSSHDLIGQKLSTLFSKTDDDVAEALSEERMESDGRAAVTFGIVVDIVGRNNEKIPVSVWMKRIKNECGHCCVVVLEPVERISAWVTFQSDGKITSCDLFFAQLYGYTSSEEVAGLQIADLIPSVQIPPPGKKIPKNLEVQRTVGRAKEGTTFPLSLKLKPRIPEGEPEETKTEPPSDYCFFSASIWVFTTISGLITLLPDGTIYGINNSFALMLFGYERSELIGKSITVLIPGFYNYMDPVDDSSLPLVHLVDCLEMENMSSAEERKKSHAGDWHLASSAEGKWRTITVNIFPAGDEVRSQSEKLKLAGCERGELSVRAHAQPRNGGGLPSNPSTPPGTSANLPTHGEQPLSENQQSRTYKEESNTHPSLPDGHFPGKTDTRPSILDSSFKFSVDPNEGSPPIKTQPEDRNVRVGGLLPVARRESVDSGETSGHHLGEISKIEDLEDPQGYSEKAFTPDGKERGIESGTKDSIGPHSNASNISFGTPTQDEPWQEMMSDSRPERQTSAIMEQLVKPNLVWTVGRSRFESGADPPSMCGVRDGGIYGGHARLPIDCKTSGAASNSEEANGPDIKVHAICGDLKDLELNVIEGAVSGSWATSVDLRASSSFVGDADTSEENIPSPIFDAPRRPGSLKLTDASSIESQIGQVGDGCLGDDDEDPSEVCKNFEESEGEGLLRNSDGLSARPKPVQQRLKTQATSTPVKTSSEPTAKIPDVKSEILEGSYTGSCYHRDGARLSMQFEVKRVELKDPAALFCCWVGKDFFQSHKEATARTQLFLSSVPSSSQSIVEVSGFSLGEIMRTKRWFDDPPRVMEMEILKACEGEYSEHYNTLTPIGSGAFGFVWTAKNKEENKEVVVKFIWKNKILEDCWVEDPELGKVTREILILSEIQHPNIIKVLGVFENEGFFQLVMEKHGSGLDLFTFIDHHPSLDEPLASYMFRQLVSAVAYLRSKNILHRDIKDENIIIAEDFTIKLIDFGSAAYMERGKLFYTFCGTIEYCSPEVLMGNPYRGPELEMWSLGVTLYTLIFEENPFCELEEAMEAVLNPPYYVSEELMNLVSGLLQPIPEQRTTLEKLFQDPWVIQPVNLANYTWEEVCPFAKPGENWETRSYRGNRRLNQCPRNLTGNR
The following text describes a protein:
Function:
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQRGPAGGRSSSPKPSAPGSGAGEGPDGRSAPASQKINKASANDRSLDSVIAADKIAALKLAPVSRETEARLDRYIALLREWQAKTNLVAPSTLPHLWTRHIADSLQLVDLAPTARRWADLGSGGGFPGVVLACTMAETPGASVHLVERIAKKAAFLREAIRITTSPGVVHLAEIGDNVDRITGPVDCVTARALAPLHQLIGFAEPLMRQGAKALFPKGQDVEAELTEAAKYWNIQPQLHQSRTGDGWIVELNAAERRG
The following text describes a protein:
Function:
Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTAVADAPQADIEGVASPQAVVVGVMAGEGVQIGVLLDANAPVSVMTDPLLKVVNSRLRELGEAPLEATGRGRWALCLVDGAPLRATQSLTEQDVYDGDRLWIRFIADTERRSQVIEHISTAVASDLSKRFARIDPIVAVQVGASMVATGVVLATGVLGWWRWHHNTWLTTIYTAVIGVLVLAVAMLLLMRAKTDADRRVADIMLMSAIMPVTVAAAAAPPGPVGSPQAVLGFGVLTVAAALALRFTGRRLGIYTTIVIIGALTMLAALARMVAATSAVTLLSSLLLICVVAYHAAPALSRRLAGIRLPVFPSATSRWVFEARPDLPTTVVVSGGSAPVLEGPSSVRDVLLQAERARSFLSGLLTGLGVMVVVCMTSLCDPHTGQRWLPLILAGFTSGFLLLRGRSYVDRWQSITLAGTAVIIAAAVCVRYALELSSPLAVSIVAAILVLLPAAGMAAAAHVPHTIYSPLFRKFVEWIEYLCLMPIFPLALWLMNVYAAIRYR
The following text describes a protein:
Function:
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. Together with PAT1, the LSM1-LSM7 complex binds to osmotic stress-activated mRNAs to attenuate the osmotic stress response, probably by limiting ribosome access to the mRNA and consequently translation. Component of the nuclear LSM2-LSM8 complex, which is involved in spliceosome assembly. The LSM2-LSM8 complex plays a role in the biogenesis of the spliceosomal U4/U6-U5 tri-snRNP complex by accelerating PRP24-mediated annealing of U4/U6 di-snRNA. The LSM2-LSM8 complex binds U6 snRNA terminating with a non-cyclic 3' phosphate group. LSM2-LSM8 is probably also involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM2-LSM8 could be involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA, although involvement may be indirect. In a complex that probably contains LSM2-LSM7, but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA; the complex also associates with snoRNA SNR5.
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm.
Sequence:
MSLPEILPLEVIDKTINQKVLIVLQSNREFEGTLVGFDDFVNVILEDAVEWLIDPEDESRNEKVMQHHGRMLLSGNNIAILVPGGKKTPTEAL
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular Localization:
Cytoplasm.
Sequence:
MATENPIRMSGNNERWSNSRPVSVPNRSESAPPSMEGSFLAVDSLLSRQGHDRAAQEPLNTHPNKHNLTRTPSPPVYYPTTEYQLVDSRVGSFRSNQGLSIVNIPIHSPQATLSTHKEVSEDEVSPQQHSVNSVSDRTNVVDTSLSQGLADTRQDGSSSGPTPQHRRPNSSDGEMNTADESGNFSEMSGDVVVKDNPASVGTEKSLDESTIISKMKNTNISGPGTAKHPREQPRNARPERQMYPQQSNVTWIQNGGNMGYQSVNGTTGQFHYGQQHVLHQSPGFTPPTQTGYVTSPAQVYNMQSPGVYSPQYGYGPYTNMIPPHPQFIPGYPSHGSVPLIVRPEYIPQLHGPSAGSVVHRGAESFYAPPGQPSFPDPMYMHYSQHSLGHMNAPRGNHKNAPEPHKDESRFVRQIRGPNNSNMGLNYYGVQPNMVQYLPSAPPSPGYVPYVEAYPGWQQQGSLEGTNGPRLCNFLEELKSGKGRRFGLSDITGHIVDADQHGSRFIQQKLENCNPEEKEAVFRELLPHACKLMTDVFGNYVIQKFFEYGTPSQRMELADQLMGQIVPLSMQMYGCRVIQKALDVIEPDQRVRLARELDGEVMRCVRDQNGNHVIQKCIESIHADRVGFMLSAFRGQVSSLSMHPYGCRVIQRLMERCSNEHQCHFITEEILESARVLCKDQYGNYVIQHVLEKGTSEERERIVRKLSGHIVQLSLHKFASNVIEKCLEHGGRIERDLIIKEIAGADESYDSLLMMMKDQYGNYVVQKIFETCSVDQRVVLVSRVRMHASALKKYTYGKHIVTRLEKPFGQGTE
The following text describes a protein:
Function:
G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production. Plays an important role in microglial function, controlling morphology and phagocytosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNYSTEIQTNNSDLDSVFTLRVLPSLYCLVFVVGLPLNCMVAWIFLRLGADSGLVVYLQNMVVADLLMLITIPLRVADNLGFQNKDLYVITCRYTDVLFYTCLYMGIIFIGFISLERYAKIVHPSSSASCTPRFSVVSLLRYLEKTRCAWVVVLLSWVILLAIVLPNVVMTSKDPTGKNFQDCMLLKTPAGAQWHTGIIVFNTILFWVTFVIVTFCYGSIGMEVYRSQTRICQDSTGACGRSSRSIFIILVVFFICFVPYHACRIQYTHCQVQESKDCCRDSVVLYHLKEVTLFLSALNVCLNPVIYFFMCPKFQETLKRKLSERRRRRSQTVKQTCKHLGINNFHERNK
The following text describes a protein:
Function:
Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus. Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded (By similarity).
Subcellular Localization:
Nucleus. Note=Localizes to the nucleus in both hyphae and yeast.
Sequence:
MSEVEYNQENTHYAEVDNFDRDAMSQTRARSRSPVAGGAPSSDRRDRDRTDRTDRTDRSDRPRSFNDRAIASQHAATQASRKSQKNCRVYVGNLSYGVKWNTLKDFMREAVDVLLGDTRDGSITRARNASAARWLNESRRQCGWIADGKVLRFCPGWVTGGILQHLNHVRVAIQHSTRFPSFHRQPSIVYTAGHVVFSEVLTLPNGSSKGCGIVEYSTPEEAQKAIREMTNKQLEGRQVFVREDREDEVRYGTSPGGPPRGGGRGGLGGSSGRGSFGPPVRGGFYGGPPPPPYGGFGGGAPTQLFIGNLPFDVSWQDLKDLFRSAGNITRADINMGHDGRSKGSGIVAYADSNDASNAIAMYHGYEFRGRMLEVRLDKFASAPPMDPYGRAGYGPPPRGGRGGFGGAYGGRGGYGGRGGYGSGYGDPYGGGYSHEAYGGAYGGGYGGGYGDRHGAAGGYSTRASGPTSARAPAPPAAPSQQIFVKNLPWSTSNEDLVELFQTTGKVDEAEIVIGGGRSKGCGVVQFATVEDAETAIAKFNNYVYGGRPLDIEFNRRWTKFGTGGGSVNGGNDGNAPMVEVSAQDDEDGDAPVPMQG
The following text describes a protein:
Function:
May regulate endocytosis in response to extracellular stimuli.
Subcellular Localization:
Cytoplasm. Note=Localizes at the cell tip and barrier septum.
Sequence:
MRGELNIPALSRFGKSISASLHHQNGSSRDDNDSNPYENRSSNSGLNRRNSVFGLPSSGLSSRLSKPSLSSINNSNNSSSNTGGNVLPNPALTPVRNMSNKPPLTWSPSSANLFGTSKVTSIIGNNVSDVVPPVIKKALASSHGGGMSLSIVLLEPVLYLAGFDLNECQIENPALLRGALVLRVAKPANIRGISLSFTGRSRTEWPEGIPVKGHDTYEDKVIISHNWKFYEPTMKDADAPQHGADVARLVGEQLPLPSSAAASLRGYSVFAPGEYTYNFDLAIPNCFPESVEAKMGWVRYFLEATVERFGTFKSNLNGRTPVQLVRTPSPASLSSSELINISRDWDERLHYELQVSGKSFRLGEVVPITFRFLLLDKVRLYKLSISVVESSEYWCRSRKFHRVDPKRRVLLAERSAKHQNTDNLFETPDEGDGLSSAVFNFNVALPTCLVKERDRLTFDTTYKYIKVRHRLKALLVLSIENTENPEKRKYFEINIETPVRILSCRCVKDSTLLPPYESSSQGDNQVLLPCPCRLATTHVEPTEVTAFTTQSVLASSAPSAGRPAAAQISRPAQLFRIPSTNPPPFDGDVCPPACNTPPPNYDELFDVLSSISIQDCETDRANDDTILNNRVRRSGTIREEAPHRSLSRTVSRSFEIPR
The following text describes a protein:
Function:
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Subcellular Localization:
Nucleus.
Sequence:
MGASALDEEAQAKILRQVEFYFSDSNLPGDKFLLKCIEEAEDGLISLPLICSFSRMRSHLGLKEHGADTVPAEITSAVADVLRKSSTLRLSEDGAKVGRVEKLKAPTEVQAEVDARSLAINPFPWNVTLDEVELFFKDHCKVNSVRLPRLAGAKSFSGYAVVEFASEEEAERVKGLKLSFQGAELESISKKAFEELQEINAQKAKQSNGKGRHDTGRVDEDEDDYPKGTVVSLTLTKLVKAGEESTDDAKVETNKEAGEEETKDAAVDTEMQVSREDIKETLKNYGKINFVDFSRGDKAGFVRFDLPEESQKARAAAVLASDGGFVIKEHLVVLNAVEGEAEKDYWKKLREGQGKRREGGGRGGFGDRGGRGGRGGKFGRGRGGGRRDGRRDRDERGEGRGSKHKRFEENEEGGERKAARTD
The following text describes a protein:
Function:
Catalyzes the formation of long-chain N-acylserotonins and N-acyldopamines, which are important cellular signaling lipids. Catalyzes in vitro the formation of various N-acetyl-2-arylethylamines such as N-acetyltryptamine and melatonin.
Sequence:
MSAITIRAMTIGDYEEVEAFLAVHFFKQEPLMLIPQEDPKQSEVSSAEAELHRSLIPQDLSLVAVDGERIVGVVLAGELVPEDLEREYQEAEQKEITCLLDKIHKFLAGIERQANIFKHYGVERALYLYMLGVDVSIRRQRVGTRLVEATIELGRQRGFPVVTSTCSNQNSKRLMTALNMECILTKDYADYKDEHGEIVLRASEPHTSASVVAIRL
The following text describes a protein:
Function:
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTLRPFTCNDMFRFNKVNLDPLTETYCLSFYMQYLAHWPEYFQVAESPTGEIMGYIMGKAEGQGESWHGHVTALTVSPDYRRLGLAATLMSFLEDVSEKKRCYFVDLFVRVSNKIAIEMYTKLGYIVYRTVLEYYVGDPDEDAYDMRKACSRDVHKKSVIPLEHPVRPEEVD
The following text describes a protein:
Function:
One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.
Domain:
Has three domains each corresponding to an enzymatic activity, namely in N- to C-terminal order: ligase, kinase and cyclic phosphodiesterase (CPDase).
Sequence:
MKDSQSDIIELCNKLNEATKLKRNGKSIKLTNFVSNTQIKLDSWKFLEWDYGKPSVQLPIQARGLFTLNNDTIAVRGYDKFFNVEEKPFTKETNLKTSTHGPYEVTLKENGCIIFISGLSTGDIVVCSKHSTGDRIDDNESDKTTTATATATAPTRNHAKQGEFELLQQFDGDQQKVKQLAHYLYENNLTVVAELCDDEFEEHVLPYPKDKSGLYVHGLNYNTITFKTLPMDQVLQFAKEWGFKYVSYLTYDNADELFKFLHKCSETGTYNGREIEGFVIRCHRQSHTNGDTDGDCFFFKYKFEQPYLLYRQFREVTKQLLNGTPINSIKIKKNKPITKKYLQFVEKLFEQEPEIARNFENGFDIIKVRQLFLQSLNETNGMNLLSIDSELSDQLKNLALANGNEGLSTTTKYIFVPIATIGCGKTTVFNTLNNLFPQWTHIQNDNISKKAKLKICDLTLLALEDDDQSVVLFDRNNSASRERRQIFTTIDQKRDEHLDDTVDLKYIAINFIPEDLSEEELWDITYNRVIQRGDNHQSIKSQSDENLVESVMKGFIQRYQPINTSRSPDDQFDHVIHLKLSKDENSSKSSLENVRIIIDDLVQNFPDLIKEKPADELINECFQKALDYKPTFVKNMTANTIKKDPTYYGIAMHYSSILENLEIVSHNEHFQNIKSHIQTEFHVTLGHIASSKQDKAGRVKWKKLVKTLGKGDPNKPKSALKFFADVKLLQIVINTDKLACIKVEILKIYDTNDVLQSEIEPINKQLHITIGCIPPATAVESNITLEELYDNPDEQELKPDGTYKCGDDTLHVFNFDNPDLKLFSQQLFVAYQ
The following text describes a protein:
Function:
Exhibits oxaloacetate decarboxylase activity. Lacks any detectable aldolase activity with 4-hydroxy-2-oxopentanoate (HOPA), 4-hydroxy-2-oxohexanoate (HOHA) or other 4-hydroxy-2-oxoacids.
Sequence:
MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGPAAHTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIATEFELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVGMRA
The following text describes a protein:
Function:
Possible transcriptional activator.
Subcellular Localization:
Nucleus.
Sequence:
MATYCDDLGPSSAPPGQAQATAHPPGYEPGDLGAVGGGPLLWVNAPALSPKSYASGPGPAPPYAAPSYGAPGPLLGAPGGLAGADLAWLSLSGQQELLRLVRPPYSYSALIAMAIQSAPLRKLTLSQIYQYVAGNFPFYKRSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRRAEASAAVRSGARSVGGAEAPALEPPSAACLDLQASPSPSAPEAATCFSGFASAMSALAGGLGTFPGGLAGDFSFGRRPPTVATHAPQTLNPSPGFAPGHQTAAAGFRLSHLLYSREGTEV
The following text describes a protein:
Function:
A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation.
Subcellular Localization:
Cytoplasmic vesicle. Recycling endosome.
Sequence:
MSLMASAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPPLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRKKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVGKDKKKKSKIKTLFSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEGKGETKDSSPSSSPSPRGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRRFSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAAKEAKESKKPESRRSSLLSLMTGKKDVAKSSEGENPLTVLGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNPFEDVQITEPEAEPESKSEPKPPISSQRAPQTRAVKPRLEVSPEAQPTARLPSPADSPSSLPLPSSSGQAPVPSELGHGTDTQSSESLSVFSSLSSPIAAPISTSTPIESCPLIDRGQAKSEEPPLLPKAELQTESLTPVPNSGSSAPGSLFKQPSIPVNKGTENSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPHKKQDYSPSSGEAQEVPSALSLSSDGAASPVGELVAGGDKDLESQAGSLVGSKARDAVEEAAPPLPMGESVPSIDSTMQKLEEMGLNLREGQKKTKKRVSFSEQLFTEEVVERAVPLVEGHSSCPQELTPAWAVAGNASAGEPPGSPHTEDSERESVTTPGPATCGAPASLAGHLLLPSLEESFSEGPTSEASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLASDFKSPVTADLNLSLPSIPEVASDDERIDQVEDDGETAKSSTLDIGASSLSLVVPCPERGKGPSGKADRLALGEGLRDFSLQAPKASVTTPSEQTTEFGIHKPHLGKSSSSDEQLPGPSGGEEEKPMGNGSPSPPPGTSLDDPVPSPSPSELFPATQSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNATTTKVANSSLGTATIISENLNNEAMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGKM
The following text describes a protein:
Function:
Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
IEQLYSCVSLQHLDLSDNNISTIGDLTKLAALKTLLLHGNSITTLRTVPAHLPAHLSILSLAENEIRDLNEVSYLASLHELEQLSIMSNPCVMATPSLPGFDYRPYIMSWCLNLKVLDGYVVTQKEGLKAEWLYSQGKGRSFRPGQHVQLSQYLATVCPLTASPALETAENAKLEKILSKQRFHQRQLLEETQGGCLSPPRPTQLDVERHSPSHPLGGAQEEKEFNTWVSCDSAHASLPVVHSQRLAEEHIYLEDVQTDEDKLNSSMLSSESVFLPFTSDTDLHTTHTDTEDETETFEPDSLALKRPKTIEKEAGAITPAPPAFGAGAPLDGPEASTDRAEIKGEVGLFLRKTMTEADKAAVKIQSWWRGQHTRCCHPTAKEVRGEIRLRRMQDHIVFLTDKLENVQKQLEDERLQRLVQEEAMKFLWKELQAVQQWKQSVEQQLAAVQPATPQITPPAPLCSAAPPVVPKSPNPPGAEASFPDSGFQSTLDQQWGQEDSFLSSGTADSLKTVRALSPAGGGVDSTDCSLLEQYLSSVQQREEEAEEERSEKTETPPASSPGSPSRAAPTTHLPTKRETTPPAQAESSDSVRDPNMLEESPSDKELLCTEPERVNQ
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MLTLLNRWRSQPGGASNAAAFIRVLESPKSAVTDKVLVLKAFNDWDVLVNTWFEVADALPAVEQLLDNNTFPEHSSAALLVSKVYFCLEQYERALEFALRGDFNVVPATRTGLGNDAEYVNKIIETAIDTYKTLSKQGSGIPQKLRDLIDRIVARNLDKREIWFVISLGFETTNLAMIDRAISAMPADLTIKNQTTLVETLNRVVNGAFDRSFRFQVIDTVIKTYLKCPSPDMSKICECYVLTDNAEAAADTITSLIAKSLSTRAYQIAFDLYETASQGFLDRVLKRFQQQDARDEKSMEKIHSILKGHETVKAYLDFFVRHNHTDSVLMEEIKENIRTASAHNALLISNGLMQYGTTCDDFLRNNLNWVSKATNWNKFNAVASLGLIHHGQESSAMKVLEPYLPKESVEGFGFKEGGAMLAYGLIHAKHGDATAMSTLAQWLKTAENEPVRHGACLGFGVAGLGSSSVSNYEKVREVLQRDEAVSGESAGIAMGLIMAGHLNQEVFNELKQYTVDTQHDKTQRGIRTGLACAAFGLQGDAEPYIKEAIGAKSNPMLRSTGICMLSMAYAGTGSPDVVRRLLEKVATDPNLDVKRYATIGIGFVLSKDPSTCLSYVAMLTEHFNGHVRYGAAMALGIACAGTGNMEAIALIEPMISDKEGFVRKGALLSLALIMCQQTDYTCPKVNGFRKQLLKKIGEKNEDSLVKFGAIIAQGLLDIGGQNAAVTMQNSDKQPDMGSMVGMMCFLHGWFWHSMHFFIALAAKPSCLVMMNENLKIPVLDYICHANSQKFAYPPRAESKKDKDVKKIETVVLSITGKKNASKKLIAEEKKRREAAASASSAAAAPSSSSTSGTAPAAEDEKMEVDQPGKSKKEKAPEKDTKPLHRLQNPARVIPAQRQLISISDARAYSPMKPLYKGGIIVADRVDKEREEKLVSEVVTQVNTPASSGNTENKPHSTFEININDF
The following text describes a protein:
Function:
Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
Sequence:
MTESFADLFEQSLQTLEFRPGSIVRGTVVAIENGMVLVDAGLKSESPIPAEQFKNAQGVLEIAVGDEVDVALDSVEDGFGETQLSREKAKRHEAWIVLEKAYEDAETVIGIINGKVKGGFTVELNGIRAFLPGSLVDVRPVRDTAHLEYKELEFKVIKLDQKRNNVVVSRRAVIESESSAERDALLENLQEGQAVKGIVKNLTDYGAFVDLGGVDGLLHITDMAWKRVKHPSEIVNVGDEINVKVLKYDRERTRVSLGLKQLGEDPWLEISKRYPENTKLTGRVTNLTDYGCFVEIEEGVEGLVHVSEMDWTNKNIHPSKVVNLGDEVEVLVLDIDEERRRISLGLKQCKTNPWDDFATRYNKGDKVSGKIKSITDFGIFIGLDGGIDGLVHLSDISWNGTGEDAVSEYKKGDEIHAVVLSVDPERERISLGVKQTEDDPFNAYLADKKKGTIVHGTVSAVDAKGVTVELADTVEGYIRVADISRERIEDASTVYSVGDAIEAKFMGVDRKNRSISLSIKAKDEAEEKEVMATLNKQEDAVISNAMAEAFKAARK
The following text describes a protein:
Function:
Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MPYLLEMKNITKTFGSVKAIDNVCLRLNAGEIVSLCGENGSGKSTLMKVLCGIYPHGSYEGEIIFAGEEIQASHIRDTERKGIAIIHQELALVKELTVLENIFLGNEITHNGIMDYDLMTLRCQKLLAQVSLSISPDTRVGDLGLGQQQLVEIAKALNKQVRLLILDEPTASLTEQETSILLDIIRDLQQHGIACIYISHKLNEVKAISDTICVIRDGQHIGTRDAAGMSEDDIITMMVGRELTALYPNEPHTTGDEILRIEHLTAWHPVNRHIKRVNDVSFSLKRGEILGIAGLVGAGRTETIQCLFGVWPGQWEGKIYIDGKQVDIRNCQQAIAQGIAMVPEDRKRDGIVPVMAVGKNITLAALNKFTGGISQLDDAAEQKCILESIQQLKVKTSSPDLAIGRLSGGNQQKAILARCLLLNPRILILDEPTRGIDIGAKYEIYKLINQLVQQGIAVIVISSELPEVLGLSDRVLVMHEGKLKANLINHNLTQEQVMEAALRSEHHVEKQSV
The following text describes a protein:
Function:
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
Sequence:
MSQRGDRGEGHARRPGRSSSFSGHRGGGVGGAGKGGGGPSGGQPPLSSSRSFRKPGNGHGGHQRVVNQPDTTGFQPAPAPGPLQTPPPRPPVPQNVPVHVPVSAPRPQNHDSSGVQAPSPSPASENPVYIPLPKNIPRAAPKAPSKSSNAPAPQGAPKGESSKGFNLQFGSINMNGLPQFPARTTSAPPNLDEQKRNQVLPEGLKVAPSMPVPPAVKQPHPLPQQQQPVPQQQQPTPQKQQQLLPMPQHQHQPSTQQQQLLQQQQTRKDALGPSQSNTVSTHVPSQVKRDVHVSPSIPNVTPLRPTVQSLPGMPMHFHPQQPQGPLQFGGHNQGVVPSSMQMSMGLPGGNVSQVQQQMYVQNLQQHQLQQMMHQGQPMMYPGQLQPQLTNVGLNMAQQYPQQHQNKLVAPRRSGVKIIDPHTNKEVVLHNKPVQRPPSNVATQSQQASGFAAPHMGYYPSPQQSYNQSGMYYPSTTGVSQLPTGSQAPRFTYPATQAGQPIAFMNPSMSNTLPASHKDNTAAPAASGQSHITGKLHQGGLHMEKSIPSVKISTPPVKPDTPKLRVTEHATPHQQKDNEVLSGIVVSNKSNEKESKAPSATEKHSTAVTQPLLIQATKLETDAVTSPVANSPSFLSGADRKNKEVIQRADSVKESKKNASRKDSKNSPQHPHSVSPAEELKVQSSMKFGDVVGPKEANSFNSNNELNLTSTASNLTAVSSESRVSPVVDASEANSTSINASDDPSTDIRSAKLSSESTGEVVAAAESGSDITQKTSPESSGDKISSKCAENESVQTCTMDLVQQTSVEPPKPDNSDATACVTDHEELQKDSTPSIPDEQSIVNRSHGNTEVSPAFVDGNAPSAADSATSSESTIHISNDKDDMSIQDAGSAISSITPSMLPVDHSVTSEGQGEHADAVKDQSSVDQSSAAPTGSIQPLSREKPTAELTRTKSSSGKKKKRKEMLSKADAAGTSDLYNAYKGPEEQSESSATAEGADSSSMVDGTDVLPEDSEREVSAREDDGKKKVEPDDWEDAADMSTPKLHSSGSGNQASVVQVPDSDTNEANGRKKYSRDFLLTFAHQYPGLPVGIRMDNVTSSLFKDLVGKSYVIDREPHPSPGRGSDRPTSRGDRRGAAMDDDKWTKLGVPFSPGRDAHMDLTNGPAVMNYRGAPGVNHGVLRNPRGGLLVGPMQSIAPQIPRSGSDADRWQQKGLMPSPVTPMQIMHKAEKKYVVGKVSDEEQAKQRQLKAILNKLTPQNFDKLFESVKEVNIDNVATLTGVISQIFDKALMEPTFCEMYANFCFHLAGALPDFSEDNEKITFKRLLLNKCQEEFERGEREEAEADKTEEEGEVKQTKEEREEKRVRARRRMLGNIRLIGELYKKRMLTERIMHECIKKLLGGDFETLDEENIEALCKLMSTIGEMIDHAKAKEHMDAYFERMRSLSTNQLISSRVRFLLRDSIDLRKNRWQQRRKVEGPKKIDEVHRDAAQERHAQSSRLARGPVASSAPRRGAPPMDYGSRGSGPALVSPGSQQAGSRGMSSHSHGFGHQDIRFEQERHQFDGRTVPLPQRSVKDEITLGPQGGLARGMSLRGQPPLSNVELPSVDNRRVVAGANGYNSVASTPREDTSSRIPDRISGRTAPATQSAGSSHRLASQEGRTGNKSYSEDDLREKSIAAIREYYSAKDEKEVALCIEELNAPSFYPTVVSLWVNDSFERKDMERELLAKLFVGLYSGGYNLLSKPQLIEGISSVLGSLEDALSDSPRASEYLGRLLARFVLEKILLLQDVGRLIEEGGEEPGYLVREGIAADILGAVLESIKVEKGDAVLNEAKSSSNLKLEDFRPQHLKRSKLDAFM