lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase. When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity).
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MRLNGDSGPGQDEPGSSGFHGGIRRFPLAAQPEIMRAAEKDDQYASFIHEACRDAFRHLFGTRIALAYQKEMKLLGQMLYYVLTTGSGQQTLGEEYCDIIQVAGPYGLSPTPARRALFILYQTAVPYIAERISTRAATQAVTFDESDEFFGDSHIHSPRMIDLPSSSQVETSTSVVSRLNDRLMRSWHRAIQRWPVVLPVAREVLQLVLRANLMLFYFEGFYYHISKRASGVRYVFIGKQLNQRPRYQILGVFLLIQLCILAAEGLRRSNLSSITSSIQQASIGSYQTSGGRGLPVLNEEGNLITSEAEKGNWSTSDSTSTEAVGKCTLCLSTRQHPTATPCGHVFCWSCIMEWCNEKQECPLCRTPNTHSSLVCLYHSDF
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MVSLEARVREVKGKREARRLRRRGEVPAVVYGPATEPIPVKIKRSVLEKIFHTISEATPIQLIIKDDQGNTVAEKTVFLKMVQRDKVSETVVHLDFYEPTKGHRMRINVPLKVVGKPVGVEKGGFLEVFHEEIPVETDPDKVPQEIEVDVSSLDLGDVIHARDLKLPEGVKCLLEEEEAVVSVLVPKEVAIEEATEEEEEAAEPEVIKRKEEEEE
The following text describes a protein:
Function:
May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMELETGQCTIMELKKENVKELAQVFKTVAFKDTGTWHASEAGMKITVDDGSYQLASVFINPAFFSSFKVREEIVSMKISIKSISEFLSISENSSSSVKVSYPGMFQPVKMLVEDADGWVARGNFTTTLADQELDFEFDDAGVLATYLLKTQVLKEIIKDFDDTSRTVRIQFTKNSLCFTTFGDVGETTVSIPSRSLQMESVKCLEEVEFSYLLSLIQRMTTAFILATKLILRVDERGVLSCQFSIDHGEGNASYIEFLTVPADEEE
The following text describes a protein:
Function:
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR.
Subcellular Localization:
Cytoplasm.
Sequence:
MELFLRRRLAFLSFFWDKIWPAGSEPDHGTPRSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGSPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDNIYSPSSSSEIPVKWTAPEAANYHVFSQKSDVWSFGVLLYEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHPRVLT
The following text describes a protein:
Function:
Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR. ArlS/ArlR affects expression of the multidrug resistance transporter norA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the presence of the poly-N-acetylglucosamine (PNAG). Also, Arl proteins are required for the efficient activity of DNA gyrase inhibitors and high osmolarity on spa expression.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEIIIYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIEYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAFGVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDASHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHSLKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIFDRFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF
The following text describes a protein:
Function:
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure.
Sequence:
MSSPTSTSPKSSFVFSPTSFPHAAIASNNVRPRTNLPPPPPPDRIPPPKGRSHQQKFKILRKEKDKDRRQPIDLEDDWTIEDVTVNGDGVEQESQYLDDLQPEENELKPGPRFLEMANREEKKEKTSKSRGLVKKTSRLFGRDKDKDRGKPEEPAVTGSSSSTLAAMRQSSSTSTDSTTSRSITSAFTRQNSIQSRRSPRTSFGQAHSRRASQDSQMSWPAPRSIRSSTTSHDPSSDPQNSASSTGVPIPQRQGASMSSLSRYSLPHPNGGTSRSPDTFPNKMSTWFSHLLPVSSGSPPSSSYETSSSIRKQSSVAASLFNAARQKAVDGVRHLLDSEAQPDKCMDTIWVRGVAHPGWRPITPENSTSNLPALEPGGSGGGVEDRRASLSMNGPSPNSLRPSSWKRNTSLPPTGQPQSPAHVHTQASNQTTSPSKGFTGIWNPSTLSLGMPIGGSPNKEKENGSGAESPSKKKSKEIVKWPEQFYDDFKSTVWFTYRNQYAPISSLSPNLLIPSPEAYYASFGPPLDATSPSSLRVTTPTAAAQQSASGSGGWGWSKEERGLTSDAGWGCMLRTGQSLLVNALIHIHLGRDWRVPSTPASFSEATTTQEIAALKDYAKYAQMLSWFLDDPSPLCPFSVHRMALIGKELGKEVGEWFGPSTAAGALKTLANSFAPCGVAVATATDSIIYKSDVYTASNLPSDDWNSISPTFNSSKKKRRGDNEAKEEKWGKRAVLILVGVRLGLDGVNPIYYDSIKALFTFPQSVGIAGGRPSSSYYFVGSQANHLFYLDPHLTRPAIPLQIPPLPVHSAKEKGSTESSSIMSTAEEESEEGVMIRTPETPRSTTPSMFSAPEHVEDEDQEEWGQGSKYKLDVVDADGVEVEGIDDDKGRNEGKMIREEVPKSSFESNGAAQEQPKKQKGFTSTASIDSQVDSQVDPHMLWYTTAYPDPLLRTYHCEKIKKMPLSGLDPSMLLGFVCKDEDDFEDFVERVAQLPKKIFTVQDEMPSWEEDDDAGLESVSEPDFEGDEFEEPGTAKPRFDSSSPVNEDSLKGPRVVSASTTATPLAAKEEDHLDVEEANSTDDDNESIGTTTAAGPMDIARHLNRVDLSSKREQEGDDDDGEWVGGTPSSQGVLVEPPSLKGTPSKSRSSAFEPRYEQNGETEQERPVFPARNRMESWVEPVCEGKEAPNGDNLL
The following text describes a protein:
Function:
Putative transcription factor that acts as a key negative regulator of cell accumulation in shoot and floral meristems. Negatively regulates the size of the WUSCHEL (WUS)-expressing organizing center in inflorescence meristems. May act by down-regulating expression of WUS. Can compensate for mutant ULT1 protein when overexpressed.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MERECGSKELFSKEELQEISGVHVGDDYVEVMCGCTSHRYGDAVARLKIFSDGELQITCQCTPACLEDKLTPAAFEKHSERETSRNWRNNVWVFIEGDKVPLSKTVLLRYYNKALKNSNVSKVIHRDEFVGCSTCGKERRFRLRSRGECRMHHDAIAEPNWKCCDYPYDKITCEEEEERGSRKVFRGCTRSPSCKGCTSCVCFGCKLCRFSDCNCQTCLDFTTNAKPI
The following text describes a protein:
Function:
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain (Probable).
Miscellaneous:
MISCELLANEOUS: It was also suggested that 2-thiourine geranylation and 2-thiouridine selenation in the tRNA chain may occur independently, in two distinc metabolic processes.
Domain:
Composed of a rhodanese domain and a P-loop domain, which probably binds geranyl diphosphate. The two activities are mechanistically different, but the rhodanese domain is important for both.
Sequence:
MQDRQKAQDYRALLLADTPLIDVRAPIEFEQGAMPGAINLPLMMDDERAAVGTCYKRQGADAALALGHRLVCGDIRQQRLEAWKAAYQRFPNGYLCCARGGQRSHIVQRWLQETGIDCPLIEGGYKALRQTAIQATWQLAQKPILLIGGCTGSGKTQLVRQQPNGVDLEGLARHRGSSFGRTLNPQLSQASFENKLAVELLKINARQTLKRWVLEDEGRTIGANHLPECLRERMAQAPIAVVEDPFALRLERLREEYFIRMHHDFTHAYGDEAGWQAYSEYLHHGLFAIRRRLGLQRFAELTDTLDRALAEQLSSGSTDGHMAWLVPLLNEYYDPMYRYQLEKKAANIVFRGTWQDVANWLKAQ
The following text describes a protein:
Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Sequence:
MSGTNDIKKVGITYEDRLPYLMSIETGKSFATVVKELCSHYQLQNPDDYTLYLNMPNCYKFLTDNNWSEIQNGSVLNLVLSVSRQAKAIHESIQRHKSENIKDNLKRLSELSTDETFANAFISIGGLTTVENMIRGANNVDERLSYLLKSFIDLMDFDPSAWGTVDHEFIKIVSNCTNSVRNLENSVVQASLDIIESIIMNCPDMYSIVEQEITSTSLIPHLQSSTEGIQTSALAVFNALFMKGSSEKKRRIVDNSNFKSLRNIILTCIIHRGNPSQGMLRQLHVLQSLLFNVIDEKQNAPVDVNDSNALLQIKELRQIAFDTDPDLTPIAKRQSQLKDFKRLGFQNHMNPIEDFLATPPGLLPLHNMMYFAENHRENYTKVVLENSCRGDDHDMPFAQASIELTQLIGETLKIADQPTEDGRSYHPLFFTNDHSFEEFYCICIQLFNKTWKEMKATVADFTKVIGVVQEQIIRALENQPMTFEQFRNKLSKLTYQEISNLWYQERMMKIEWGLQAEPILELRKQLKVQIIELIEKQRLNYLTEGTKFSLKAYRRQDKFMYCRLSVNMLTLHYGECEENNAPSCEQLAYNVAINEIKDVLVGKDCPHVKDIKKKVANANLAFTIVLEESCSAERADLLNFLAPNEEVFNIWMDGLNILRKRQMSSEDMKRDLDTLLNMEIKLRLLEAEGLTIPDTPPPIPPLPSNFDFPEELL
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Sequence:
MKILTRQYHTIRPNYRKLQHIHFPGISSFQHGLNIQQLLVDANLDYKSLEFKYRRIQRQRQQISTNTNDSSLLALKNKIENLQPLPTILTFEFDNVYAGGLRSKSEVSPNDLEGFKRIGGQYFQLERGGQVTWHGKGQLVAYLILDLKSFVKLSTKCYINNVLLKSIQNLLKKTYHLDSVVGVENPGVWIKDNKSKSSSESLKISSVGVRIRHGITEYGIALNINPDLKYLNTFEMCGLKNKRATSIHKQLSHLPVPSVEHVGKLFVDEVALALEMNSVEHINANSL
The following text describes a protein:
Function:
Has a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSHNLGYMEYNKGNTGYNSGENYPSMDQYNYGQGNMGNMGNMGQQYQPPQQQQQPPQQQQQHNSGFGFPSPTLYNMNAQQQQQQQQQHQQQQHHNQQTSPMYGNNGGFNQFNNNDNSHYSPPQQGDMSRQFISQISDNPLTQAGLTYGLNYGQTLFSGGKQYVDSNFGKYFSFSTLKSYFNVNNSYVFNKIKLLIFPYTQKTWKRRIGRTSDVDSYLPPRDDINAPDLYIPLMAFITYFLLYGFQMGMEKKFSPDYLGACITKGIVFWAIELLIFKCGFFFSNSNSIPFYDMISYSGYKYVLMVIFQIATILLGSYVSYIIKCVLSVSIAFFMLKTLRLVFSSVSGAHDHISPDYHESGKIKNYFVFGFSVAQALLCFLV
The following text describes a protein:
Function:
NAD-dependent L-serine dehydrogenase that catalyzes the oxidation of L-serine and methyl-L-serine and is possibly involved in serine catabolism. Has low activity toward beta-hydroxyisobutyrate.
Sequence:
MKQIAFIGLGHMGAPMATNLLKAGYLLNVFDLVQSAVDGLVAAGASAARSARDAVQGADVVISMLPASQHVEGLYLDDDGLLAHIAPGTLVLECSTIAPTSARKIHAAARERGLAMLDAPVSGGTAGAAAGTLTFMVGGDAEALEKARPLFEAMGRNIFHAGPDGAGQVAKVCNNQLLAVLMIGTAEAMALGVANGLEAKVLAEIMRRSSGGNWALEVYNPWPGVMENAPASRDYSGGFMAQLMAKDLGLAQEAAQASASSTPMGSLALSLYRLLLKQGYAERDFSVVQKLFDPTQGQ
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MTEDIHQKIELLNYCVNILKVQDTNSNISLEDANHILCDFQKDPESYLITENIFNSDSDIMVKFTVLQNLESCAERRWNLVEQDIKENIINYLLELVFSPENEMPNQLINKIYDIFNEILIQDYNASQSSFFIRVRQTISQEEPRNPKHLEKYFNLIGSFMLFLSIKMGEENNSYLYRRFSYNHFNNLSKQFYNSDYDNVQEDITDALDPAGNDDEVINSALNCCCSIIKCNSFVSQKLYQNEFIEKVKESFMSRPKLAATSISIVNEIFAKIVLPDYANPLKFTSDVLEMLLSKCNTIQLSENSNCWPSFIDLLSKLLDLYGIYIINGDQFNFVFDVALGITEKANTDILIESCEALLYEYLIQANNQVTQEDFDTCFIPRIATILVDKMPAPLVIEPFIDLYNNEEKRVVKNEDFESMRKCISAIDVFFSQLVIDVIKAKKPKLETIDDIEHFCWAVSTVSNKEALVPGKAYPFLEEIFRYLMYEINGITNERQGEYDETAERLGICFSVVVMYSFEFIGDNNELFANVFEALFDLLNFGWEKLLLFVINTLLFISIANTSIFSQPNESWENKTAIDILLDKLNETITLENYKDELKLFVHCLCRSINSIKDTEYGRRCIEALKQIIFKRVEFCMINFNKESIPTWKYFTNTLSIMNSYVETFSSQYIDIFRTINLGEFMNSFKDIYASSGDLLVRELCRNCRASIMLHLHKFISYLDDPKTTIMPVLERDFIYVIMTDYSQSDPDLCLPQTLTFLATLIARMDDELQDMINDIMDRVFEKTTVIIESDDQYKYPDLSEEFYSFLDRLINSMPKYVLSLEFDQLIKIYEILRFGCNSSLQEQSINCLQYIRNFANLMETAQSDNQEIYMAYKQSICVDLGKLGFKLLIDGLHKFAIEEIGKLVLLVFKSNNSEEFMNQFSSSLENDATPDLIDIVIGTVKQILNTNADEKNIEEILRDFIMKAVQETSDNEETVRERMKKNVESINELLKKSNKRQTSTVDEVIKNRELPKDSELNDLFNSLKNNLKF
The following text describes a protein:
Function:
Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
Miscellaneous:
MISCELLANEOUS: The structure in 4KV3 was determined for a fusion protein with E.coli maltose-binding protein.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSAPAVAAGPTAAGATAARPATTRVTILTGRRMTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Sequence:
MARALRDISLFNDIRKDQNSAGAKHERYNMRDLRSKKNQHVNGIDDYEDDSLDRFIRRKKSRVVKYIPSLSAYNVFNEFPYYPTSASQLLDGKLDEFLMLSEQYKSRLPKIRKLGWNRFKPIGINKTMYELEMLRSRARAQNAEGNNEEDFRQHDSREEDPRNNGSIGRVILPHILQENEEYDTGEGVTGLHSMPNDSMAILANNSANNSQNEEVSEEDEISYDYDAEFDHVVDEDDNEEGEVPGEGVEGIEVQRERIVPDDLLMRPTSLSRSLQQFVEEAHHLDRNPYDIDSDNDGEDSKVELDMNPDFEDDVGREHDYNSEYSQEPTSYGGITPDLASNWRNWTRERITSLDELMERRARQQRGQD
The following text describes a protein:
Function:
Transcriptional activator. Is activated when bound to the antibiotic thiostrepton (By similarity).
Sequence:
MSYSVGQVAGFAGVTVRTLHHYDDIGLLVPSERSHAGHRRYSDADLDRLQQILFYRELGFPLDEVAALLDDPAADPRAHLRRQHELLSARIGKLQKMAAAVEQAMEARSMGINLTPEEKFEVFGDFDPDQYEEEVRERWGNTDAYRQSKEKTASYTKEDWQRIQDEADELTRRFVALMDAGEPADSEGAMDAAEDHRQGIARNHYDCGYEMHTCLGEMYVSDERFTRNIDAAKPGLAAYMRDAILANAVRHTP
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MDSIPLPRMNELYKDRTLFITGASGFVGKVMIEKMLRSLPGIRRIVILIRPAKGKSGRERWKEIEKLELFNRIRRNFPERLAKVVTIEGDISQPNLGISQDDLNRVLDETSMVFHCAATVRFNAPLKEAVELNMRGVTRVISLCHRMPKLECFLHCSTCYVNADKQGTIVDENVYPPPCDPHKLIESDDWLSESLFESIGTGASKSYGNTYCFTKCLAEHIVLEDAATLPALIFRPAIVGGIWRDGIPGWADCYQGIAAMLTALGTGALARVPIDLSARLDTIPVDIVASAMIVSAAYRMRMREKTIPVIHCNSSTLNPMIFGEVRPTAMECAFKYPWTRTYHRVGETYAVLKKFLTDYTFQTDILPRLMEMMTEEDRETFELDVRKVNWNDYIFDLQLGIKVFLMKDDIVNANSIERARRNVKLHQIKDFIITFFLCYVFSVICTGSTGSWQLFLPLTIILHCYCSVFTYNPRGVPSIEEYKRRVENAMGELLK
The following text describes a protein:
Function:
Substrate-recognition component of the SCF(FBXO31) protein ligase complex, which specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress, leading to their degradation by the proteasome. Fbxo31 specifically recognizes and binds C-terminal peptides bearing an amide: C-terminal amidation in response to oxidative stress takes place following protein fragmentation. The SCF(FBXO31) also plays a role in G1 arrest following DNA damage by mediating ubiquitination of phosphorylated cyclin-D1 (ccnd1), promoting its degradation by the proteasome, resulting in G1 arrest (By similarity). The SCF(FBXO31) complex is however not a major regulator of ccnd1 stability during the G1/S transition (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
Zinc-binding is required for the structure of the protein and facilitate folding.
Sequence:
MAVCARLCGVGQSGGCRRRRQRKGAGNDPELEDEEEEDEVRIEAEVLVEGQAAVAPLRPRSLLQLPPEILVEIFSSLPGTELPSLAQVCRKFRQILTTDTIWKRRCKQEYGVCENLRKLEVTGVSCHDVYVKLLHQYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDEGMRLKPVFRIHLMERNNATVECMYGHKGPHNGQIQIVKKDEFSTKCLQTDYHRMSGGRQEEFRTWLREDLGRTLEDIFHEHMQELILMKFIYICQYDKCLTYRRIYHPPNRPDDLLNPGFFKGTYGSHGLEIVMFSFHGTIAKATKITGDPNVPAGQQTLEVDLTRPVQLPDVEHLRNFDEISRLILDVQSQIQREQRQTGNEEDDGKGAGPDRAEHSQQPAPVHRPAKEDVNGVDNADDREQKPPNVQSFVLPAGVMARNEEYPRSCKMCFYGTGLIAGHGFSSPERTPGLFILFDEDRFGFIWLELKSFSLYSRMRDRFQHSEAPSLEAFDEMLQHMQSWTT
The following text describes a protein:
Function:
Glucosyltransferase involved in the glucosylation of the steroidal alkaloid aglycons solanidine, solasodine and tomatidine to produce their corresponding glycoalkaloids.
Sequence:
MVATCNNGEILHVLFLPFLSAGHFIPLVNAARLFASRGVKATILTTPHNALLFRSTIDDDVRISGFPISIVTIKFPSAEVGLPEGIESFNSATSPEMPHKIFYALSLLQKPMEDKIRELRPDCIFSDMYFPWTVDIADELHIPRILYNLSAYMCYSIMHNLKVYRPHKQPNLDESQSFVVPGLPDEIKFKLSQLTDDLRKSDDQKTVFDELLEQVEDSEERSYGIVHDTFYELEPAYVDYYQKLKKPKCWHFGPLSHFASKIRSKELISEHNNNEIVIDWLNAQKPKSVLYVSFGSMARFPESQLNEIAQALDASNVPFIFVLRPNEETASWLPVGNLEDKTKKGLYIKGWVPQLTIMEHSATGGFMTHCGTNSVLEAITFGVPMITWPLYADQFYNEKVVEVRGLGIKIGIDVWNEGIEITGPVIESAKIREAIERLMISNGSEEIINIRDRVMAMSKMAQNATNEGGSSWNNLTALIQHIKNYNLN
The following text describes a protein:
Function:
Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template.
Sequence:
MEFFRPTELREIIPLPFFSYLVPCGFPSPAADYIEQRIDLNELLVSHPSSTYFVKASGDSMIEAGISDGDLLVVDSSRNADHGDIVIAAIEGEFTVKRLQLRPTVQLIPMNGAYRPIPVGSEDTLDIFGVVTFIIKAVS
The following text describes a protein:
Function:
Produces N-formyl-kynurenine through the oxidation of tryptophan.
Sequence:
MLEIILLIGALAYTIAYASARLTRICSTRMKVPVPVVVPIQGKVKEKIDENENVSKYQALRNLRDQHEVAAVMSRLIDEDGAGAWPPNANHDSWPIALSPYREVYFQLIPILSAAPPSLDDDVNNERRKKYRSIMRKSLMEKVNIPQVVAIMAAVEAGNWDLFPRDAYNGFYCCVAVCRHAYRWATIPVVKVAQLEKIVEFPSELDAPWPYLQRNFGVDGDAGNNTSNVLLNFNTRGERIYRINVGMSDLIRSSEEVFFQMFYDLEVVAFPIYHEMVLSILAYTSSSPNTCLPHFRTINTRLRDLFLVFYENLTKSRVSHSVWLSYIQGFQGWGVGKMVNGEYVKYDGLSGNHVLFFQALDAFLGMDRYLSDENMERYIPIRQRELCLALKKYSFVKGLGEKGYSEIEEEFAKMVNQLKVFRSAHRARVMSYLQEPAPERLVMTAGKSVLEYSNTKGLADSLKPLDDMLATRLRETSNIGAACVRA
The following text describes a protein:
Function:
Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor which may act as a receptor for Wnt ligand mom-2. Plays a role in controlling P7.p vulva precursor cell lineage orientation during vulva development. Regulates pop-1 asymmetric distribution in P7.p and its daughter cells. Plays a role in the migration of ALM neurons during embryogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Localizes to the basolateral cell membrane of vulval precursor cells.
Sequence:
MILRYLIFFAQLWALCLANVNMFISKEEMNRTFGVKAELNYIEMGNVSSYSTKFHYRVMANIDYLSFTWNAVGIVHYEVYVESDDSSVLPIVRIPLKGTVPESLQDFTVEYRCAGHRSGQFAVSLYFTFKYGNKEPLKVKLRQEKICASRDGRRGLNGGYEGHEVDDTDSIDKAFFVIICIAAAFLLIVAATLICYFKRSKKEDMIPTRLPTSFRNSLKSTKSAQPFLLSTPRDGPPTLSAISSAPCSSSSASGNSIIPSKPRNIDVRRALLQLYQDRDAFQSLPLDMEGTFGEVRYAIWRQVDDVLNGDVDDEEDTFCNQEAVYTKTLKNNASPIQLDRFLSDALLFYNITPHQNLSQVACVASFGRFDRPETVTDFPLVCYRHQGFGNLKKFLTICRHGDKTKGAQTLRTHQLVSLATQVSSAVAHIHKYRIVHNDIAARNCLIAEVNGRLQVQLCDSALSRDLFPADYHCLGDNENRPLKWMSPEAIANELYSSAADVWSLGVLLWELMSLGGSPHAEIDPEEVYTMILKGKRLQQPNNCPDQLYEVMLCCWRVLSEDRPSSEQVVHGLRDFNIQLSQYI
The following text describes a protein:
Function:
The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTVEQNVLQQSPGPKHQQTFLNQLREITGINDIQILQQALKDSKGNLELAVAFLTAKNAKAPQQEETTYYQTALPNNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLEESNRAFRETGITDEEQAISRVLEASIAENKASLKRTHPEVWSDSPNPYDRKRQDSSPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYNLSSAQDLPRNQKEHRNLPFMRELRYLFALLVGSKRKYVDPSRAVDILKDAFKSNDSQQQDVSEFTHRLLDWLEDAFQIKAEEERDGEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHKNREITRIKREEIKRLKEYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVEDIDAAAPSSGSQTSPSTTEQQGAPSSEIPSTSPTPRSVIHKPFTQSRIPPDLPMHPAPRHITEEELAVLEGCLHRWRTEVENDTRDLQESIARIHRTIELMYSDKSMIQFPYRLHAVLVHEGQANAGHYWAYIFDHHHERWMKYNDISVTKSTWEELERDSFGGYRNASAYCLMYINDKEQFLIQEEVHKETGQPLVGMETLPPDLRDFVSEDNQQFEQELLDWDAQLAQKAQQEKLLASQTLSDTIPKVVAAQAGQPEYLEQPSRSDLSKQVKEESVQAITKAAASDHEDKSSEAVLQTASEKATSQPDPNQRVVEVAIPHIGTFVIESEEGGYDDEIMMAPNMQGIIMAIGKSRSVFDRCGPEAGFFKAIKLEYARLVKLAQEDTPPETDYRLHHAIVYFIQNQAPKKIIERTLLEQFADRNLSFDERCRSVMQVAQAKLEMIKPEEVNMEEYEKWHQDYRNFRETTMYLMVGLEKFQKESYMEALLYLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEHAAQLFESGEDQEVTRGLIIMNEFIVPCLPLLLVDEMEEKDIVAVEDMRNRWCSYLGQEMEPNLQEKLTDFLPKLLDCSTEIKGFHEPPQLPPYSTHELCERFAGVMLSLSRTPADGR
The following text describes a protein:
Function:
Plant-specific actin binding protein. Associates with F-actin at the plasma membrane in growing pollen tubes. May be part of a membrane-cytoskeletal adapter complex.
Subcellular Localization:
Cell membrane. Note=In growing pollen tubes, forms foci at the plasma membrane, but not at the pollen tube tip.
Domain:
The NAB domain, also called NAB (NET actin-binding) domain, is sufficient for F-actin binding.
Sequence:
MLQRAASNAYSWWWASHIRTKQSKWLEHNLQDMEEKVEYTLKIIDEDGDTFAKRAEMYYRKRPEIVNFVEEAFRSYRALAERYDHLSRELQSANRTIATAFPEHVQFPLEDDSDENEDYDGRPRKPPKHLHLIPKGINIPEVPDIPKKKDFRSQSMMLSRKGPADLKRNVSSAQAKREAAIVRSGLSKEEGLEEIDKLQKGILALQTEKEFVRSSYEESYERYWDLENEVTEMQKSVCNLQDEFGLGASIDDSDARTLMASTALSSCRDTLAKLEEKQKISIEEAEIEKGRITTAKERFYALRNKFEKPESDVLDEVIRTDEEEEDVVQESSYESEREDSNENLTVVKLAEKIDDLVHRVVSLETNASSHTALVKTLRSETDELHEHIRGLEEDKAALVSDATVMKQRITVLEDELRNVRKLFQKVEDQNKNLQNQFKVANRTVDDLSGKIQDVKMDEDVEGAGIFQELPVVSGSEDSRDDLKSVSTEKTKKDVIAVKESEDGERAQEEKPEIKDSFALSETASTCFGTEAEDLVTEDEDEETPNWRHLLPDGMEDREKVLLDEYTSVLRDYREVKRKLGDVEKKNREGFFELALQLRELKNAVAYKDVEIQSLRQKLDTTGKDSPHQGEGNNQLEHEQGHHETVSISPTSNFSVATTPHHQVGDVKRTPGRTKSTEVRVKFADVDDSPRTKIPTVEDKVRADIDAVLEENLEFWLRFSTSVHQIQKYQTTVQDLKSELSKLRIESKQQQESPRSSSNTAVASEAKPIYRHLREIRTELQLWLENSAVLKDELQGRYASLANIQEEIARVTAQSGGNKVSDSEISGYQAAKFHGEILNMKQENKRVSTELHSGLDRVRALKTEVERILSKLEEDLGISSATEARTTPSKSSSSGRPRIPLRSFLFGVKLKKNRQQKQSASSLFSCVSPSPGLHKQSSYSRPPGKLPE