lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Exports stored molybdate from the vacuole into the cytosol, making it available for molybdate cofactor (Moco) biosynthesis. Plays a role in molybdate homeostasis as high cytosolic levels of molybdate are toxic to cells. Not required for molybdate import into cells.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MFFTKPRLHRIITHNLHHLLSPHLLLSEISGSLGDLGTLLPLLLALSLQGSIDLPSTLLFSGLFNILTGLVFGVPLPVQPMKAIAAASLQENADLETTVAAGAWVGFAVLLLGGTGGLKRVMRWVPGAVVRGVQVGAGMSLVVAAGGGMVRPLGWLWTPEENENGHGGLGEWLDSRALAVLAFGGLVVGLGQQQQQQQQSGEKPQERRKKRSKMPVQVPYALVLFLVGIMFAVVRVSLSKDSPQSPPPPPHDQPTNSAPPWTWIWNPLNHIHPKVFRSLLNPQALSMAIAQLPLTTLNSIIAASALASDLFPPDSYPQLYADDESSDSPLSPSPSASSSSLSSAPPQTPSAETPKPLSSPTSAEEGPVPLTPLSLSISAMNLLSAPFGCMPLCHGSGGLAAQHRFGARSGTSIILLGLTKFLLGLFFPGPGLLGLLGKFPKAFLGVMVLGAGVELARVGVRNVEGEEQDRMVMLMTAGTILAFKNDGVGFLAGMGCYGGFRVAAWLGGGTEKGRGGEQGLLGEEEEEEEQGRVDEESPLLR
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity).
Sequence:
MDKNFRVNTNDERNIWLSTAVNENLTMASSSSQPQPISSPFHQPENQVNRVNPGSHYYDLETLESSFGGLSFNDSSVGQNGDSIHLPRRTNQVFTGSSSGGAGDDNGYLLPPMGSHHHRELEELQRHNYLNQLRMSYQNDYAHQSYWYNTDGDGNGMLNNGFLNDVPSSSRDRVSDYYTNRFGYEGYNYWRGNEGFDYNQCQASFSAFAKDKEMSERLGMSIFQGTKETVDAIYNGLIGDICELMVDPYGSDVVQLLMRRCSSEQIVQLVDIVTQQMFQFVNICIDSLGTNAIQVLLTCINERAKDQIPRIVDVVRTVALQLSKSNHAIFVILACFRLFPLHCRLLLELIVQNCHQIAIDQHGCCLLQLCFNKDRVPNLEIRQRLIMEAIANALRLCLNCYGNYVVQYIVELNNRYLIDALVRQLIGNYAHLARNKYGSHAVQKLLKLRWIDSRVIVIDLLREIDTLLLDPFGNYVIQTAWFVSKDDVRRMLRYHIERNIPMMRCNKFGNKVLEKLNI
The following text describes a protein:
Function:
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL
The following text describes a protein:
Function:
Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium. May be involved in pre-B-cell growth.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAVQACALSLRLGLWMSLLLPVLPGAGARAAGARWSGEGTTPHLQSIFLGRCAEYTTLLSLEPGNKNCTAIWEAFKVVLDKDPCSVLPSDYDLFINLSRHAIPRDKSLFWENNHLLVMSYAENTRRLMPLCDVLYGKVGDFLSWCRQENASGLDYQSCPTAEDCENNAVDAYWKSASMQYSRDSSGVINVMLNGSEPKGAYPTKGFFADFEIPYLQKDKITRIEIWVMHEVGGPHVESCGEGSVKILEDRLEALGFQHSCINDYPPVKFLMCVDHSTHPDCAMNSASASMWRESPALHAIGDISLIISLLVALASSSQA
The following text describes a protein:
Function:
Enzyme of the diterpenoid metabolism involved in the biosynthesis of both phytocassane and the oryzalexin class of phytoalexins. Can hydroxylate syn-pimaradiene, ent-pimaradiene, ent-sandaracopimaradiene, ent-isokaurene, ent-kaurene, and ent-cassadiene, but no activity with syn-stemodene, syn-stemarene, syn-labdatriene, C11-alpha-hydroxy-ent-cassadiene or syn-pimadien-19-oic acid as substrates. Hydroxylates 3-alpha-hydroxy-ent-sandaracopimaradiene at C-7-beta, resulting in a 3-alpha,7-beta-diol corresponding to oryzalexins D.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MENSQMWLLWGALSVALFFYFSTLRRRYAGGKPLPPGPTPLPLIGNLHLVGGGTFHHKLRDLARVHGPVMTLKLGLATNVVISSREAAIEAYTKYDRHLAARATPDTFRACGFADRSMVFIPSSDPQWKALRGIHASHVFTPRVLAAVRPIRERKVGDLIAYLRAHAGEEVLVGHAMYTGILNMVSFSYFSVDIVDMGSQMARELREVVDDIILVVGKPNVSDFYPFLRPLDLQGLRRWTTKRFNRVFSIMGDIIDRRLAHIRDNKPRHDDFLDSILELMAAGKIDRVNVLNMLFEAFVAGADTMALTLEWVMAELLKNPSVMAKARAELRDVLGDKEIVEEADAARLPYLQAVLKEAMRLHPVGALLLPHFAMEDGVEVGGYAVPKGSTVLFNAWAIMRDAAAWERPDEFVPERFVERTPQLDFRGKDVEFMPFGSGRRLCPGLPLAERVVPFILASMLHTFEWELPGGMTAEELDVSEKFKTANVLAVPLKAVPVLIK
The following text describes a protein:
Function:
ATP-dependent cytosine methylase that maintains DNA methylation by acting at hemimethylated palindromic 5'-CG-3' sites to produce symmetrically methylated DNA strands. DNA methylation may play a role in transcriptional silencing, particularly at transposable elements.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to heterochromatin characterized by trimethylation of histone H3 'Lys-9'.
Domain:
The chromo domain is involved in binding heterochromatin at histone H3 tails methylated on 'Lys-9'; The helicase ATP-binding domain contributes to identifying hemi-methylated CG DNA motifs; The SAM-dependent MTase C5-type domain is involved in hemimethylated DNA binding.
Sequence:
MTTALTFGGGLFKDNTKFDIDMRGTADGAVNGGNIPNSQSQKRKRASPSPEIESEEDGDDWYEIDYIADSRVIRRKGRQILQYLIHWAGYAVHERTWEDEDGIGGEDCALVQEFYRKNPGKPRLSPSSVRKEVKLARMVEVVITTRRIDGKSRAASSTDQPSPHRLGITSPQANNIGGEDPNPSLTRRPVRSTVSEIAKRPTSKKVHPNKKCKASSDDESDFVFEEGEWDEDEDDDNDVDFRSSEDDEDDEQERSAEEPESDEEIIKPAKKTKSSLPKAKLRPKPANLGGFVTGVRPLNQGLDIKAAVRNMSDDLPPISDIEAMFDHLVSRIPDIVELVRQLNGRKLRVATMCSGTESPLLALNMIAKAIKAQHGLTLAFEHVFSCEIEPFKQAYIERNFTPPILFRDVTELGKKRAHTAYGSMVDVPGDVDILIAGTSCVDYSNLNNVQQDIDANGESGRTFRGMLQWVKKHQPPIVILENVCNAPWDKVVEYFGQIDYDAQYTRLDTKEFYIPHTRTRVYLFATPSSSESDDLPEKWAQTVKDLRRPWSSPFEAFLLHTDDPNIHRARLELASARAQTDGTSRKTTDWNRCESRHQRARQDEALGLLRPLTSWQEAGVCKGLDWTWNDWLLAQTERVVDLLEISTLRMAKDGIDSGFKACIWNVSQNVDRQTGSSKTALAPCLTPNMIPWVTIRGGPVTGREALALQGIPVRELLLTSENEDQLADLAGNAMTTTVVGSAMIAALKVACHKITEGANPEKEAALILEKEAVDDEQVANRIIGEDYLEHHDLDLAKVTKSNLSEILDLACRSSRHCQCEGQSGTAPNILECQECSYRACKSCGGRPEHVYAPCANQRVEPAEFEKRFKGLLPMRVRIAGLTDQCLNAVRKAAEKSNKGSVNDNDWQLWSTALLEGIHDAEFRFRYLKRQSTWTAVYEARRAMLSLVLRNQIPEWRLTIKAPASEPNNSQLRALLLHPVARLQIDIAGQDVLCGPWELCIPSMKTIDIEITGKGELLPSWQASLGLQGPFANTTRWSEVEISLQAEDENTLDRKLSGTYQLLPRCGQAMSSLHKKRPDLSDDGLPQLYFFLDPTRCGESREDRYVFSTSTERLDYGTERPVIARLDSHWREGNEKQRKVKLDVSGAWVKCPEAHLTAIGGDDIAVVANDAAANEIHRDRATFAIPSSASAISASLTTEGCSHAMALLSCRVPLDPTHSESMWRRGAWAEIDLSHQGNTTFANLAWITERLPPLDGLKNWAHIADDVSEHVCERCAPRPPKIHWIKREGKANKKGNKTKSTIIAFEDKLEAGQYEHALKHRPSPFVVQLRLDQDIGSFRIGLNIVSLAHRALSRLPPTTSEHKISLSWRLTPGHVTESPQPRRVFILPSNKQDPENSQPEAFKLPLRKEQLRSLWWMLEQEKATGKTHTFVEEEISESLLPAVGWRAEGKAERPVMVRGGVIADQVGYGKTVISIALVAQTLSLPAPEPATPGLIDLKATLIVVPGHLSKQWPNEIARFTGSMFKVIVIQGMKDLQEKTIAELGKADIIVMASEIFESDVYWSRLEYLSAQPREWLHDTQGGRFFCDRLDAAMESLVSQTKILKEKGSEAAMRAMEDKKKSLVDNVGSKKEVHTAVNFGKRMKGQAYRDKHDSDSKAKPITKEELERWEASEDEDDDENSKTYIPIPKFHSFTGSESIFSASVKKDYKLLPNPVLHMFRFRRVIADEFTYLQKKSLAAVLRLSSSYRWILSGTPPVSDFAAIRSIATFMGIHLGVEDDGEGDVQYQKARAKDQTQAEKFHAFREVHSRAWHNRRDELAQEFLNVFVRQNIAEIEDIPTVEHIHTFKLPASEGAVYLELEHHLQALEMQARKETKFKNVSQGDRNARLEEALSDSKTAEEALLKRCCHFTLDLSDKTQDAKSAQEACDHITSARARQLLACQEDLSRSVNQAIALHGWIKKKGGFSKNDDERQPFAEWIAFSSNISKHQGDIEAARILLKVIEKCGVKDGNIPPSPSDKQSPSIASGAKMDDVKWQLREQTHLLRKLVKELVARVRSLRFFEVVRKIQKGKSDAQIVLESSECGHKPSTNPDIEMAILSCCGHVACHKCMRKAAASQRCVKSGECQAAVRPTNIVKVSSLGVEGELSSGRYGAKLEHLVNLIHSIPKNERVLVFLQWEDLAGKVSEALSAGRIPHVTLSGSAKSRANTLDRFQSTNADSARVLLLKMNDASAAGSNLTTANHAVFLGPLFTNSLFNYRAVETQAIGRVRRYGQQKKVHIHRLLALDTIDMTIFNARRTELKEKTDWEEIPQEEYKGRGSSISMTNEKRTPTLTVKSNPFKRSSSWALASSFRSKKRSMEARDAEGVSDDDENSELSDII
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MFSVPFLTSLTSHLGITAIDDASDTLSCLITAFLFIIAAILTSAQSYVGSAMECWLPQTYSGAWEEFAENYCFLKDTYFYPRQQSMTDIPMYHKERHRLTYYQWSSMYLAVAGIAFMIPKFIWRLSQSTTDMPLIYFCDTANEIKIETTEKRSSKVKEMARFMRSKITTVHTPSIFSCIRMYSVYSIVKMLYLIIAIAQFVILAIFLDQEKDMFWGWTLFMNLLNGITWETTGLFPRVTFCDFEIRETAGNNRAETVECLIGINVFNEKIFLFLWFWLLFLIFSTLVAHIYNATHIAKPYIINSLLHSIRDHGIVDQKELFKEFGEKYLTMDGKIILSFVKAQSDLVASEVAVEMYNDFLEVRDQRIYIISHEFNDIQKTRN
The following text describes a protein:
Function:
Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.
Sequence:
MSHLDDLPSTPGKYKTDKVPPYGILHHHRYLRLSKLTLWASLFLALFLFYLVLSPPPSPSRRNLNDSSSISAAKYGGSHWEKQVRKSARPRSHGGLTVLVTGASGFVGTHVSIALRRRGDGVLGLDNFNRYYDPKLKRARQGLLERSGVFVVEGDINDAVLLRKLFDVVLFTHVMHLAAQAGVRYAMQNPGSYVNSNIAGFVNLLEVSKSANPQPAIVWASSSSVYGLNSKVPFSEKDRTDQPASLYAATKKAGEGIAHTYNHIYGLSLTGLRFFTVYGPWGRPDMAYFFFTKDILKGKTITVFESPDKGSVARDFTYIDDIVKGCLGALDTAEKSTGSGGKKKGPAMFRIYNLGNTSPVPVTKLVTILEKLLKMKAKKKIMPLPRNGDVEFTHANITLAQAELGYKPAVDLETGLKKFVKWYMGFYTGSKKKSSW
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MRPGMTILELHGNMYQMKRMAVYDEFCRKQSAVLVATDIAARGLDFPAVNWVIQLDCPEDVNTYIHRAGRTARFEKGGEALLVLLPSEESMAEQLTARKIPINKILVNPRKFVNVQRKMEALCARDVSLKESAQRCFTAYLKSTFLMKDKSVFDVKKLDLEAFARSLGLAVAPRVRFLQKHLKQVQAKEEKDKAARRGDASQPSQSAATEDRLGVTSVSPWRGSDTKAFQFHTQDDSEDSDLEDIFTVKQRITYDSEENAEAELPADEERKKKKPLTKAAVAKKILRKKLVANTKVAFDEEGKVIEEGVNVQKADTIKELLKDEKTPCGIDLEISKKILQEEDKFDKQRDRERVKAMHRAKRLKLRQERKQEQGEVTLDAESGNEEEEKVEGSEEEQSNNEDSESGEESHSGSEDADTDEELLPQASRSKRPLGDSDSKVASKKRRVSEETSDEESEEDELAPLDTGLDLLGDEALALHMLSHK
The following text describes a protein:
Function:
Shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis-pNPP).
Sequence:
MISRRRFLQATAATIATSSGFGYMHYCEPGWFELIRHRLAFFKDNAAPFKILFLADLHYSRFVPLSLISDAIALGIEQKPDLILLGGDYVLFDMSLNFSAFSDVLSPLAECAPTFACFGNHDRPVGTEKNHLIGETLKSAGITVLFNQATVIATPNRQFELVGTGDLWAGQCKPPPASEANLPRLVLAHNPDSKEVMRDEPWDLMLCGHTHGGQLRVPLVGEPFAPVEDKRYVAGLNAFGERHIYTTRGVGSLYGLRLNCRPEVTMLELV
The following text describes a protein:
Function:
Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Required for autophosphorylation of ATG1 at 'Thr-226' and its dimerization. May also be involved in the regulation of autophagy through SNF1. Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase.
Miscellaneous:
MISCELLANEOUS: Present with 149 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Domain:
The extended 70 Angstroms-longloop of ATG13 specifically binds the highly conserved innergroove formed by the armadillo repeats of VAC8.
Sequence:
MVAEEDIEKQVLQLIDSFFLKTTLLICSTESSRYQSSTENIFLFDDTWFEDHSELVSELPEIISKWSHYDGRKELPPLVVETYLDLRQLNSSHLVRLKDHEGHLWNVCKGTKKQEIVMERWLIELDNSSPTFKSYSEDETDVNELSKQLVLLFRYLLTLIQLLPTTELYQLLIKSYNGPQNEGSSNPITSTGPLVSIRTCVLDGSKPILSKGRIGLSKPIINTYSNALNESNLPAHLDQKKITPVWTKFGLLRVSVSYRRDWKFEINNTNDELFSARHASVSHNSQGPQNQPEQEGQSDQDIGKRQPQFQQQQQPQQQQQQQQQQQRQHQVQTQQQRQIPDRRSLSLSPCTRANSFEPQSWQKKVYPISRPVQPFKVGSIGSQSASRNPSNSSFFNQPPVHRPSMSSNYGPQMNIEGTSVGSTSKYSSSFGNIRRHSSVKTTENAEKVSKAVKSPLQPQESQEDLMDFVKLLEEKPDLTIKKTSGNNPPNINISDSLIRYQNLKPSNDLLSEDLSVSLSMDPNHTYHRGRSDSHSPLPSISPSMHYGSLNSRMSQGANASHLIARGGGNSSTSALNSRRNSLDKSSNKQGMSGLPPIFGGESTSYHHDNKIQKYNQLGVEEDDDDENDRLLNQMGNSATKFKSSISPRSIDSISSSFIKSRIPIRQPYHYSQPTTAPFQAQAKFHKPANKLIDNGNRSNSNNNNHNGNDAVGVMHNDEDDQDDDLVFFMSDMNLSKEG
The following text describes a protein:
Function:
Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.
Sequence:
MDFFTECNKCGKCKQLCPSYQIFLNESFSPRGRIMLIKTLEKQKEIISGEPLKQRIFSCLLCGTCESLCPLDVNVSTLIYKTRAKMKKNLSLYLFKYFSFYPGVFFSILQNLSRSKLFLNYEKFSFLNKFSTLNIKPKQTGGLQVYSKLKPIGRIAIFSGCSTNYLLPSITNSLIYILNWLNYEVIVPKQHCCGAPLLSAGFKKETAKLAQKNIEIYKSFNIDGVIAPCPTCSHFIEDVYKEIIGEGISLLKLSDLFDKSQRNLNEFIKNSLEHKIFFHVSCHSSNYTKDADKIMELLQKFGISDIQKKTGCCGFGGLFSFLFEKQSMDILQKKVLEYEKADMIVSSCPNCIIQFKIAMRDKKILHYTEVIHKILLEGEKNGRKFFKF
The following text describes a protein:
Function:
Mediates the splicing of pre-mRNA by binding to the stem loop I region of U1-snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MAFLPPNLKIMFNPRHPPPFLPPPPPSNLPPYTGLRDYLSIFTDPSNEEPFKKEHIENLEEKREKKRKLKISENDERISKSLKAWDPYSNSETTGDPYKTIFVSRISYKTTQQKLEFEFGQFGPIKSLFLVKDSNNPEKHTGYAFIEFERERDMKAAYKQADGMKIDDRRIVVDIERGRVIKNWKPRKFGGGLGNTRAGGVDVNQTFSGREMSESREKEKEREKEKEKEKERMEKMKKRDGGLSSNGNRSNGISSGSGGSGGDRGDRGDRDRGDRGDRSDRSDRDRERGRGDRDHRGSGGERERERDQRDRGGDRGGDRGDRSDRGRSDRGDRGDRSDRGRDDRERGRDDRGDRGRDDRRGGSDRDRDRGSRDDRGDRDDRSDRGRDDRRGGSDRDHRIDERRRDQRDYGSISDAHFDHFQYQPQQHHHHQQNHQSHHNQPHPERVNRDYSMISNENGF
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MATETTTATPTAPSATTAEITPLPAFSPDLYQRAWASIPHPSLPLIATCHAHSVTVFSLSTLSKHSVLTGGHTRSVRSAAWQPPRGKVSGKEAKRLRLVTGSFDTTAGVWTWDQGRREESLEREIRLQSGENDQEAEEEEEAEDEWELTLVLEGHENEVKSVNYSPSGQYLATCSRDKSVWIWEDVGNPNPSSEEEDEEEEDEDEWETVAVLQEHDGDVKAVAWCPDVPGRKGKYAPPRRYGDDVLASASYDNTVRLWREDGDGEWVCVAVLEGHEGTVWGVAWEGRPRENDKFPRLLSWGADEVIRVWSLKEPEEEEHGEGAAGGGGNNTWGFGVPNTMRRSLKEEWECTAVLPKVHKGDIYSVAWSTETGLLSSVGSDGVLALYQETANTTEKNEENETNGEAPTTTSAGGWKVLTTVKGAHGPYEINHITWCKRYDAGSERKGEEEMLVTTGDDGVVRPWQVRIQ
The following text describes a protein:
Function:
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).
Miscellaneous:
MISCELLANEOUS: Lacks a RGD motif, contrary to the human protein.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The ZP domain mediates dimerization; The N-terminal OR region is composed of two intertwined domains (OR1 and OR2) with a common, novel fold. Each contains 12 beta-strands that form a parallel beta-helix-like structure, plus a single alpha-helix. The OR1 region mediates interaction with GDF2.
Sequence:
MDRGVLPLPITLLFVIYSFVPTTGLAERVGCDLQPVDPTRGEVTFTTSQVSEGCVAQAANAVREVHVLFLDFPGMLSHLELTLQASKQNGTETQEVFLVLVSNKNVFVKFQAPEIPLHLAYDSSLVIFQGQPRVNITVLPSLTSRKQILDWAATKGAITSIAALDDPQSIVLQLGQDPKAPFLCLPEAHKDMGATLEWQPRAQTPVQSCRLEGVSGHKEAYILRILPGSEAGPRTVTVMMELSCTSGDAILILHGPPYVSWFIDINHSMQILTTGEYSVKIFPGSKVKGVELPDTPQGLIAEARKLNASIVTSFVELPLVSNVSLRASSCGGVFQTTPAPVVTTPPKDTCSPVLLMSLIQPKCGNQVMTLALNKKHVQTLQCTITGLTFWDSSCQAEDTDDHLVLSSAYSSCGMKVTAHVVSNEVIISFPSGSPPLRKKVQCIDMDSLSFQLGLYLSPHFLQASNTIELGQQAFVQVSVSPLTSEVTVQLDSCHLDLGPEGDMVELIQSRTAKGSCVTLLSPSPEGDPRFSFLLRVYMVPTPTAGTLSCNLALRPSTLSQEVYKTVSMRLNIVSPDLSGKGLVLPSVLGITFGAFLIGALLTAALWYIYSHTRGPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA
The following text describes a protein:
Function:
Involved in defense responses. Contributes to slowing defense responses toward Magnaporthe oryzae.
Sequence:
MGILVILVDLQCCRCDAKIRKVLGCLEEEYCIEKVEYDVKNNRVIVRGKFDPEKLCKKIWCKAGKIIKEILIVDVWPPPLPQPPPPCKPPPCEKPPEDCKPKPCHCCSCEKPKPKPKPCHCEKPKPCHCEKPKPCEKPPPCKPEEPPKPPPEKPPPKPECKLVPYPYPVPYPYAGQWCCPKPEPPKPPPEPPKEPEPPKPCGCSHAFVCVCKPAPPPPPPCGCSGGHGNCGCGIRPWPPQVWPPPPVCPPPPWCYTEDNANACSIM
The following text describes a protein:
Function:
Probable hormone (By similarity). Required for the proper formation of the central nervous system by attenuating cell proliferation during development.
Subcellular Localization:
Secreted. Cytoplasm. Apical cell membrane.
Sequence:
MLSEKFHLRLLTLLTLLTALSLTDVASESKLEKLLMKRVDRDVKPAAAVAVSPSKAKEFLTSLKRPKRNLWDRSRPDVQQWIQQFMYMGFDEARLETDLAYWMDQHRSSDQGRQHHYDENAALGPRGAASYRHGANVNYDYY
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MSSGLKTQNKMLEILHEHSIESPENLFVFNNKSPHQQQDELELPVKKKLRQCDSSILENNNTEHSNNNNLETNKQLLKQSSFSVPSSNFYIPCSFNESTDSIIPNLDDINSNTNNEINSGNDNNNNNNNNNINSNNEDKNIDRNRVDDNEEEVFCNDLTKGEKRVINFLNDDDNQQCNINSFCNINNDQQQPQQHHQYQNYQEQEQDSTTSSLNSSISDLEDSDSQTIKNLIIENNFDEKIEEIKNVEGNIILLSSSSSSSSTLTNSDSSTTTTVMCTSTSISTSTTPPSHPAFFHNLQQQQTTSIVIKEDQTKNYNHYYHSDEDLDDDCDDEDCDDDSEEEEEEEEEDEFNPFLFIKQLANAQTCPPPVALPPKDHESPKISLVLDLDETLVHCSTEPLNQPHLIFPVFFNNTEYQVFAKKRPFFEEFLHKVSTIFEVIIFTASQEVYANKLLNIIDPCKKIKHRLFRDSCVYVDGNYLKDLSVLGRDLKQVVIIDNSPQSFGFQVDNGIPIESWFEDENDKELLQLVPFLELLSNAEDVRPHIRNKFKLHELISQA
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Miscellaneous:
MISCELLANEOUS: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MRVSLFLQKQIIECSKAFQPHSTRLQWPKSQDKVFVAMSGGVDSSFSAYLLKSQGYNVEGVFMRNWLDEDSAPSGCPAERDWATVQKVCKKLNISCRRFNFEKEYWNLVFEPSLDLYENGLTPNPDVSCNRQVKFGALFDALKKHCENNVKGDWWLASGHYAKSVVNIETNESHMCIPTDKRKDQTLFLCTIRKEALEKTIFPLHNWTKENVKKQASSAGFKEIAEKQESQGLCFVSPNVGRKFRKFLQRYLNFSDRPIKVIAGKNVVGEFSGNHGIWSLTVGERCGLSLPQAQSEYFGRWYVWKKDIKNNALYICRGTNNELLMSKCIYLKDWKWCGTKLQNLEKSALSCFVRVRHQQPLQPAKVTWRNPESVKIHFQDKQRAVTPGQVIAVYVNDVCLGGGMVDTVEPEKDFD
The following text describes a protein:
Function:
Member of a two-component regulatory system MalK/MalR. Involved in the activation of maeA, maeN and yflS in presence of malate. Probably activates MalR by phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKATALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPDPSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVNEIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAMLESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKKPLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLGKQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMSMRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMILTSEKNEGTTFSIRIPYEPKEENHD
The following text describes a protein:
Function:
Serine protease involved in intramembrane proteolysis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSFRTRASNNFNNDYSHDSNLLINKYTTSFNNTFKRDIKFIQILFPSFDLYSITFFFSLLLIFLFVVIDIIFFNFSSPLFINEDVLKKIGINRFAVSNNYQYYKLVTATFLHSNIWNVLINTYYLMNIGTIIEKNYGKAEYIIIMILSVACGNLLTCATSKCLDVQMGISPILSGFIGLFLQDIIVHYYELIDKLSIFGNFIFSFLSLYLMISIFSYNGNVLGNVGGILAGVSYPYIFKSDNFHGNDKKLKIIFAIFITLLLSGSLASLIVFKC
The following text describes a protein:
Function:
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MRVASSLSCHPLQNIAEGGRAQLEAYLETRGGGRVGRSESSETMSAELFSFTREPGSPGSGPSFRSNQRKILNLLLERDTSFTVCPDLPRTPVDKLFGDSGHLSILSGGTPKCCLDLSNLSSGEMSATQLTTSADHDETGHLNSSGPQGIQLSAMNHHQNVIKCSPAQLLCSTPNALDHSKKKKDVICSSSTNKENENNTSRLLEWWAPRNLKFRKRPEGPYMSPLSLLDNGNLVENEMKYLGSPITRVPKLDKNPELEDQTEEFSDELMEFSLDDQEEAKASLNRSRLYRSPSLPENLNRPILKQVVKFKDNPIPDKVKKKYCSSHRELRKGLGLKKTVSLCDVNITHMLEEDSNQGHLIGDFSKVCVLPTVSGRHQDLKYVNPETVAALLSGKFQGLIEKFYIIDCRYPYEYLGGHIQGALNLYSQEELYNFFLKKPVVPLDTQKRIIIVFHCEFSSERGPRMCRSLREEDRALNRYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKAELLRCRSQNKAWEGERQLQEQIALLVKDVSP
The following text describes a protein:
Function:
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
Sequence:
MSKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSALFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGIRDAIQHFSQDEVKVKWPNDIFIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLDRYQFLEILLQEIEKRYNQFLTLPFSEIREEYTAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISADIDF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSNIIQLLTGEVAIRTHDVSIYFSLDEWDYIKGNKDLYREGIKEEPQKLRPMDIQNTGFLCNYMRHQLQRYTKNKRSLYCEHAASDNNGSTVPKTNPSKTVAEGAVVCGDRNTTNPDISPPKQPPKENCIKSGSPASKGGSHAVECGLKSLPEQVQGRHRSNPLIICSLTDSTSPDYISNDIKPDFLCKKRIRLDNGIKTLTEKIHTTDASTSAFGRSLDSGFPVSSLSRAIKEEPVSWEERSHSGCSMNPLTEQIEKTNTFTPIMGYSFKNSLSANYYLNGMKEEVTSFEGGTRSICSINPLADQIQRNKISAPVMGCGLNNRASALQPHVYSKKLKSNATCLSPLNTPLLQVMYCCAVCHARFASYKDLVSHLITHTEEKTISCSICGKSFKRHAEYIRHQKIHTGEKPFICSECGKCFKQRSELNLHRRGHTGEKPFSCSECGKCFKRRSIVVEHQRIHTGEKPFTCSECGKCFTQRSHLIVHRRTHTGKKPFSCSVCGKCFTRHSQLILHLRTHTGD
The following text describes a protein:
Function:
As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair (By similarity). The dpb3-dpb4 dimer associates with histone deacetylases, chromatin remodelers, and histones and plays a crucial role in the inheritance of histone hypoacetylation and H3K9 methylation in heterochromatin. The dpb3-dpb4 dimer is also required for the recruitment of sir2 to heterochromatin.
Subcellular Localization:
Nucleus.
Sequence:
MEKTYGKTVLPLSRVKRIIKQDEDVHYCSNASALLISVATELFVEKLATEAYQLAKLQKRKGIRYRDVEDVVRKDDQFEFLSDLFSI