lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Potassium-proton antiport.
Miscellaneous:
MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MANTVGGILSGVNPFHYNSSSPLTLFLFQACLILLVCNLIHIPFSMMRQPKVISEVISGVILGPTIFGQIPNYTNTIFPTSSIPGLNLVANLGIILFMFFLGLEVDIAFIKKHLKKALVIGIVTLAVPFGFGCLLAIPLFHTYANKTEGERHIKFSVFMVFIAVSISVTAFPVLCRILNELRLIKDRAGIVVLAAGIINDIMGWILLALSIILSSAEGSPVNTVYILLITFAWFLIYFFPLKYLLRWVLIRTHELDRSKPSPLATMCILFIMFISAYFTDIIGVHPIFGAFIAGLVVPRDDHYVVKLTERMEDIPNIVFIPIYFAVAGLNVDLTLLNEGRDWGYVFATIGIAIFTKIISGTLTAKLTGLFWREATAAGVLMSCKGIVEIVVLTVGLNAGIISRKIFGMFVLMALVSTFVTTPLTQLVYPDSYRDGVRKSLSTPAEDDGAADGLDSEGVDKTEINTQLNSLADVSKYRIGELTTVINTTEAISPSLKLLNYLSLGVSPKPKNNKHKNETSLSRMTTATDSTLKSNTFKIKKMVHIWSKSVDDVDTNLSVIDEKLTPFEGVGALRAIHLRLLTERTTDLLQSSSLYNDDPHFTANTDSLLQIFDIFSNLSKIPFSSEVIFSTMREKAANIATMKMDSTDLILLPLKGASYEYRGSPVFIDEKYANFDHIYSHLLGLNELSSTFFKSIFQSLKANFAVQISNTYGRLNADRFKRKRFNLLLPKPYLTQSDYLGLYLLLLICYRDGYNNDNASCSIFINSKNIDFAKDLSTAFAEHDWLNESTIKIVDIPFETKVPEEAIEKPSFIETVLDVGLSDTALADIEETTFIIGEDLPDESEPFSEEVRTVIFEGSNRRFDTLIVHHFSSE
The following text describes a protein:
Function:
Probably involved in peroxisome formation or maintenance as well as in amino acid metabolism.
Miscellaneous:
MISCELLANEOUS: Present with 1890 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome matrix. Cytoplasm, cytosol.
Domain:
Peroxisomal targeting signal 1 (PTS1) is a tripeptide located at the C-terminus of more than 95% of all peroxisomal matrix proteins. The prototypical PTS1 is the terminal tripeptide SKL (serine-lysine-leucine) but the consensus of PTS1 is defined as [S/A/H/C/E/P/Q/V] [K/R/H/Q] [L/F]. However, this description of the PTS1 consensus must probably be expanded beyond the terminal tripeptide.
Sequence:
MNQILNAQRLIQLSQFHPKLKNIWYLVAAATFSVCNEPQEIPKLYHYAMLLSNDNAHMYRFTLASQTIDLLRSELPMRKTLINENYQQPTFFQKQLTAKFREVILKTGPLAGLPRAINGLTMLKETTPDILVPHLDPIDPWEAAMGNSSPLSETSMRRKHDKTIQERDHTIQNGLRHWNSIYNKVSTRVVNNLNSSYPDLWYYTLVHVYGPLFAFDEILSAQETSLVIIASLVPQDVNPQLRGHLKGALNIGCDKETVEAVRGLAILISQWCGVSWKSGVVKL
The following text describes a protein:
Function:
May act as a cell-binding protein.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MRKKHSFFCFLLLAVATNQIADGQTKKKGKKSYSVVQSDEDDLCLIDIVFIVDSSESAKNQLFDLQKNFVLSLTDNIFQMKPVKSQNYNVKLAGMQFSSTVSIDHPFTAWKNVQNFKEKIRALVYIGQGTYSYYAISNATQLFKTEGRERSIKVAFLMTDGVDHPNSPSVQGIATAARSLGIHFFTIGLSKKNVKEEKLRLISDDLSSKQVLCLDDQNLIGDVTLELEALLRKKCMQKNCVCEMGIKGDKGDPGDAGDKGERGEPGPKGNKGDAQKGDHGEKGEEGAPGYKGEKGERGECGSPGLKGERGLEGPFGPRGPRGPQGISGPPGQPGLKGIQGNKGEQGPLGPYGPPGVPGIGEPGPKGSQGLEGKIGPPGPPGIGEPGMTGPRGPDGLPGERGIPGEGIQGQKGEKGSKGSVGPVGLPGQTIKGDKGEQGQVGPRGPAGPPGFGNPGSQGIQGPPGNPGAKGSRGLGSPGPKGQRGERGQKGEPGLPTVGLRGLKGDIGPPGLPGDKGDVGDSGNPGKKGDPGEKGSRGPTGSKGEKGLAGPKGEPGERGPPGVNGSSIEGPAGPKGDQGPIGPPGEDGFPGHSIMGPMGNPGPPGPPGLRGEKGEGHKGEAGPPGPVGPPGPEGPKGVGDPGPKGDRGLTGYRGPPGPRGIGMVGPKGIMGRDGLPGPIGPPGISIQGDKGEKGNRGLHGPKGSIGVGIPGPKGDYGDKGDPGSRGAKGEMGDPGPPGPKGAWGRKGEPGLSREEVIRLINEICGCGIRCRVTPLELIFVIDSSESVGPDNFNSTKTFMKTVIDEVSANHATTRIGIINFSHKVELVSSLETYTTKESLKSAVDKMLYLGEGTYTASAIKKAISLFQAARPAVRKVALVVTDGQADNRDKVHLDLVVKEAHAANIEIFVIGIVQKTDPHYHNFLKEMHLIATDPDEEHFYQIEDFKTLSALADKLITKICENVSEIYSRKENVLSPPPSPEPEVPNEVINTQLTPVTISETSVPHKEGISYSPRPPQTRYTEPLPSAQDHTVTTSVHRESRFPSLSIIDEARLQSRVVNPLLNVTAAKDHHPTALQPQVAKPQKDMLSDPRCLEPMKPGDCRNYVVKWYYDKNANSCGQFWYGGCSGTNNRFETEEECRRTCTDE
The following text describes a protein:
Function:
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
Subcellular Localization:
Peroxisome.
Sequence:
MQSELYSSTYGKGNVKFLKVKKDPSNPTVQDVLEANVQVLLRGKFDESYTKADNSSIVPTDTVKNTILVEAKTTDVWPIERFAAHLAKHFTTKYGHVDGIEVTIIQAKWSKIKLEGKEHAHSFKHEGPETRRTYLNYDKHTKKLQLSSSIKDLTVLKSTGSMFYGYNVCDYTTLQPTKDRILSTDVDASWTFDPTQIATLDDILSQPKLFDTTYNTARDVTLELFCKENSPSVQSTMYNMSHKILETVKQVGTVSYVLPNKHYILFNLEWKGIKDNKDLFYPAPDPNGLIKSTVGRKGDKAKF
The following text describes a protein:
Function:
Component of the phenyllactate dehydratase complex FldABC that is involved in the fermentation of L-phenylalanine via a Stickland reaction. This complex catalyzes the reversible syn-dehydration of (R)-phenyllactate to (E)-cinnamate in two steps, a CoA-transfer from cinnamoyl-CoA to phenyllactate, catalyzed by FldA, followed by the dehydration of phenyllactyl-CoA to cinnamoyl-CoA, catalyzed by FldB and FldC. Requires the activator FldI to initiate catalysis.
Sequence:
MSDRNKEVKEKKAKHYLREITAKHYKEALEAKERGEKVGWCASNFPQEIATTLGVKVVYPENHAAAVAARGNGQNMCEHAEAMGFSNDVCGYARVNLAVMDIGHSEDQPIPMPDFVLCCNNICNQMIKWYEHIAKTLDIPMILIDIPYNTENTVSQDRIKYIRAQFDDAIKQLEEITGKKWDENKFEEVMKISQESAKQWLRAASYAKYKPSPFSGFDLFNHMAVAVCARGTQEAADAFKMLADEYEENVKTGKSTYRGEEKQRILFEGIACWPYLRHKLTKLSEYGMNVTATVYAEAFGVIYENMDELMAAYNKVPNSISFENALKMRLNAVTSTNTEGAVIHINRSCKLWSGFLYELARRLEKETGIPVVSFDGDQADPRNFSEAQYDTRIQGLNEVMVAKKEAE
The following text describes a protein:
Function:
May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Sequence:
MLTEASLSIWGWGSLGIVLFLITFGPFVIFYLTFYILCFVGGGLVVTLLFGKTNSEKYLEQCEHSFLPPTSPGVPKCLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILLPLINQLSDPDYINQYVIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQRLQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDGDGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTVYADYDPYAVAGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFHMRITEQFESLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPEQVADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAETTRKGILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQTTQAPSLQKR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSTQVSISGLVQVELYQSLLNRLANHTHSFSHFNSREIGFDRGPLETISEDSNLLTLKHTIRTPGIIENDSPINYKNPIRNGWSLISLGRIEPERLSPEFSIRPIHFCPIIAGNPIEFVSALGYRRTFEYFRRGVQFVRGGVIIEIFRVYHSEDDEKPMAGADLHLITVTAIIPSAVRVSNPTNPTGTAAGTTGTTTTGTTGTTTTTTNTTNPTAAAATTTTTTTTTSSSSANSGPTVQELRNEACARVREIQAILKGLADLGRVEPF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MYHLGGAETGLPVRFLGFFQFQDSFNLSLLRGSILSFLFRVGFGFHSYFLVMENRRIRELDLNVGPFDAEYDQTLSQLMASEPENLCPVTHERIEATMFDPERQLSVGEAIGDVVGGQGSLQQSRQRNVTAGEGDIYVNGNAAGHATTHVLEIGNDHDNENTGDGGSFFECNICMDMAKDPVITRCGHLFCWPCLYRWLYIHSDFNECPVCKGDVEDTDIIPIYGRGINSTEEQENAAAEPRLIIPPRPHGRRSEGTSQNVPGEFPTFEFEELSDGDFEMTGGWPGHHFSATISMIAPPGSMPIRIIRGTGEYPYHFSWQNTELVTMDFTQGDPSTSTEAEVNLRYLHMQFLRIQEQRDTEYYYFTSTASIAQEYLNHILHHSHFNQRAQHLVQQPPHFDQPALHHAQRSQHFNRSAPYLARYPSHFNQPAPDIPSSFNFHALDYVQRHPDLNLPYKFLIQCPHSNYLVRYDFTDCQHFSQPPPHLNQRPPFFTQPPPPDARVSFSDIAAGARSGNQAADGAVEMDWMRTLSASSSRGRAAYPRAPDVNIAKFPASRRMFN
The following text describes a protein:
Function:
Required for normal Golgi function. Necessary for embryo development and pigmentation, especially for the expansion of cells and organs, and for the formation of the organized shoot apical meristem (SAM). Probably involved in the generation of the extra-cellular matrix.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MMLDLGPFSDEKFDAKRWVNSSCQARHPQDSLEKHLVDLEMKLQIASEEIGASLEEQSGGALLRVPRATRDVLRLRDDAVSLRGSVAGILQKLKKAEGSSADCIAALARVDNVKQRMEAAYKTLQDAAGLTQLSSTVEDVFASGDLPRAAETLASMRNCLSAVGEVAEFANVRKQLEVLEDRLEAMVQPRLTDALTYHKVDVAQDLRVILIRIGRFKSLELQYSKVRLKPIKQLWEDFDTKQRANKLANERSESQRLSSGDEFQSTSSQTSFASWLTSFYDELLLYLEQEWKWCMVAFPDDYMTLVPKLLVETMGVLGASFVSRLNLATGDAVPETKALAKGVMDLLSGDLPKGINIQTKHLEALIELHNVTGSFARNIQHLFAESELRILIDTLKAVYSPFESFKQKYGKMERAILSSEIAVVDLRGAVTRGVGAQGIELSETVRRMEESIPQVVVLLEAAVERCIGFTGGSEADELILALDDIMLQYISMLQETLKSLRVVCGVDGTGDGVGSKKDASAEKRESSRKMDLTSNEEWSIVQGALQILTVADCLTSRSSVFEASLRATLARLNSSLSISLFGTNLDHNLSHLKSEQTAGDLSMAGRASMDVAAIRLVDVPEKAHKLLNLLEQSKDPRFHALPLASQRVAAFADTVNELVYDVLISKVRQRLGEVSRLPIWSSVEEQTAFPLPNFSSYPQSYVTSVGEYLLTLPQQLEPLAEGISTNGDSNNEDAQFFATEWMFKVAEGATALYMDQLRGIQYISDRGAQQLSVDIEYLSNVLSALSMPIPPVLATFQTCLATPRGELKDVMKSEAGNELDCPTANLVCKMRRISFD
The following text describes a protein:
Function:
Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MSKKFSSKNSQRYVVVHRPHDDPSFYDTDASAHVLVPVSNPNKTSPEADLRKKDVSSTKPKGRRAHVGEAALYGINFDDSEYDYTQHLKPIGLDPENSIFIASKGNEQKVEKKNIEDLFIEPKYRRDEIEKDDALPVFQRGMAKPEYLLHQQDTTDEIRGFKPDMNPALREVLEALEDEAYVVNDDVVVEDISKKTQLQGDNYGEEEKEDDIFAQLLGSGEAKDEDEFEDEFDEWDIDNVENFEDENYVKEMAQFDNIENLEDLENIDYQADVRRFQKDNSILEKHNSDDEFSNAGLDSVNPSEEEDVLGELPSIQDKSKTGKKKRKSRQKKGAMSDVSGFSMSSSAIARTETMTVLDDQYDQIINGYENYEEELEEDEEQNYQPFDMSAERSDFESMLDDFLDNYELESGGRKLAKKDKEIERLKEAADEVSKGKLSQRRNRERQEKKKLEKVTNTLSSLKF
The following text describes a protein:
Function:
With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs DNA double-strand breaks (DSB) with reduced fidelity. Recognizes, processes and reseals DSBs, including repairs on incompatible DSB which require 3'-resection, gap filling and ligation. Anneals the 3' overhanging strands from opposing breaks to form a gapped intermediate, which then can be extended in trans by using the termini as primers for extension of the annealed break. Binds to the recessed 5'-phosphate moiety of the downstream DNA strand forming a stable synaptic complex even when the 3'-protruding ends of the template DNA strands are not complementary. Has numerous activities; gap filling copies the template strand, and prefers a 5'-phosphate in the gap and rNTPS , DNA-directed DNA or RNA polymerase on 5'-overhangs, terminal transferase (extending ssDNA or blunt dsDNA in a non-templated fashion, preferentially with rNTPs), DNA-dependent RNA primase (synthesizes short RNAs on unprimed closed ssDNA) and 3'- to 5'-exonuclease on ssDNA. Isolated Pol domain (and presumably the holoenzyme) is able to form complexes between 2 noncompatible protruding 3'-ends DNA ends via microhomologous DNA strands, in a end-bridging function to which it adds a templated nucleotide. Minimal primer length is 2 nucleotides; The preference of the polymerase domain for rNTPs over dNTPs may be advantageous in dormant cells, where the dNTP pool is limiting; In conjunction with endogenous or Mycobacterium phage Omega Ku (AC Q853W0) can reconstitute NHEJ in Saccharomyces cerevisiae.
Miscellaneous:
MISCELLANEOUS: LigD has variable architecture; domain order can be permutated, domains can be independently encoded, while some bacteria lack the 3'-phosphoesterase domain entirely; MISCELLANEOUS: It is not clear whether there is a 5- to 3'-exonuclease activity associated with the enzyme.
Domain:
The N-terminal Mn(2+)-dependent polymerase/primase domain (Pol) functions as an independent domain, binds DNA, is sufficient for DNA-directed and non-DNA-directed DNA synthesis and interacts with Ku; The central 3'-phosphoesterase domain (PE) has exonuclease activity probably constituted of 3'-ribonuclease and 3'-phosphatase activity. It does not function as an independent domain; The C-terminal ligase domain (Lig) binds dsDNA and functions as an independent domain.
Sequence:
MGSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIAGRPATRKRWPNGVDQPAFFEKQLALSAPPWLSRATVAHRSGTTTYPIIDSATGLAWIAQQAALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLLADIGLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAGKVFVDWSQNSGSKTTIAPYSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDGDLLERLDADAPVADRLTRYRRMRDASKTPEPIPTAKPVTGDGNTFVIQEHHARRPHYDFRLECDGVLVSWAVPKNLPDNTSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDSGTYDTEKFHDDPHTGEVIVNLHGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNLAPMLATHGTVAGLKASQWAFEGKWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALAEDLADHHVVLDGEAVVLDSSGVPSFSQMQNRGRDTRVEFWAFDLLYLDGRALLGTRYQDRRKLLETLANATSLTVPELLPGDGAQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVKDKHWNTQEVVIGGWRAGEGGRSSGVGSLLMGIPGPGGLQFAGRVGTGLSERELANLKEMLAPLHTDESPFDVPLPARDAKGITYVKPALVAEVRYSEWTPEGRLRQSSWRGLRPDKKPSEVVRE
The following text describes a protein:
Function:
Multicopper oxidase that may play a role in the maintenance of inorganic phosphate homeostasis.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MVERRFLGACLLLLAAVALADGEGEEGRWGVRLLDAGRLEKFVDELPDMPVLRGYGVAEGGRLVTGELAVGMYDTMWKFHRDLPATRVFAYGASKETATVPGPTIVAMKGVPTRVTWTNHLPPHHILPWDRSLATARLGNGTGIPTVAHLHGGVQQSTSDGHSMAWFTSGFATTGPHFSSPAYEYPNQQPPGNLWYHDHAMGLTRVNILAGLLGAYRVSDPAAEAPLGLPSGAEFDRNLVLFDRDFRSDGALFMNATGNNPDVHPQWQPEYFGAVVVANGKAWPFLRVRRRRYRFRILNASNARFFRLSLSGGLRFVHVGSDSVYLARPVPTEGFLLAPSEMADVVVDFVGAKHDAVTLRSDAPAPYPGDPGGKADMVAVMKFVVASKPEHDPSTVPATLMRQYPKPNVREAVVTRHIAMYEYTKNGTDEPTHLYLNGLAYTDPVTETPREGTSELWEVINLTDDNHPLHVHLAVFTVLKQRSLRRVDEFRDCMRGSASGGAGGRNDALACGMQRHLAGGRRHVVPRQERGWKNVFKVRPSTVATLLVRFKPLEESSATAASGKSGGFPFDVTAGPGYVYHCHILDHEDNEMMRPMKIVR
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Subcellular Localization:
Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MPEGPELHLASLFVNKVCNGLHFAGAVEKSAVSKNTDVPFNCPEYTISSVSRGKEVKLILTPLSDGSEETHIIFRFGMSGSFKFTPPDQIPKHAHLRFYTKDAPCHVLSFVDPRRFGTWVVHGSWQPERGPCVMQEYEKFRENVLKNLSDKVFDKPICEVMLNQKYFNGIGNYLRAEILFRLAIPPFIPARSVLEAVKYQNQNNELSLSKKIKIKKENPDILHLCHLVPLEVINLGGKGYDPEHSDNYSEFEKWLRCYFVPGMKSLRDSNGRTIWFQGDPGPLAPKGKKTKKRQSMNKVQKPLKVKKTAIKGKLGDVKKEKNEDIERDLDEVKAVKAAVKSRGHKTKDGVMKKGVEVKQKWGKGKEPEKQRRVRKVSSRTSALNPPARPLRERGVQGISLPATTRPSRLKSGRTSLTQDSPMEIRRSLRKHKIT
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MIQVSICSSIGKLTASVGLLIKALSSKTSQVLVGWKVIDKNSKVKIILTIEVNNQGRIFVITGPSGVGKSTLVKALLDHFKEQLFYSISATTRKKRISEKEGIDYFFKDKDEFENLIKQDAFIEWACYNNHYYGTLKSQAEQAIKSGINLMLEIEYQGALQVKSKYPHNVVLIFIKPPSMQELLKRLKKRNDEDETTIKKRLEQAKIEFQQIDNFKYVVTNKEFDKTLNELKSILLSEFI
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MKAKCTQPPSTTAKISTDGSRTGTFILGKYQLVRLXAKVYHGLCLDDDTNIAIKVIDKKSTIVDAFMETCIIREISSMVRLNHHPNIIKLKEVLATKSKIYLMEIATGGDLQAKLNRHGKFSDSISRFYFHQLVSALHYCHQNGVTHRDIKPQNILLDQNNNVKVSDFGLSALPEQLKNGLLHTACGTPAYTAPEVAYRKGYNGEKADSWSCGVILYTFLSGYLPFDDSNISNMFRLVHLRRLRFPDWVSKSARSVINRLLDPNPSTRLSIEELMKLSWFKKSELKHRQLNLGECLSERDCKNLVAVNAFDIISMSSGLDLSGLFESDMIKKEMKFTTRARVEEVEEKVMKIGEERGYKVDRRKGWGIGLVKGRVVLMVEILKVAMELLLVEVKVVNGGLECEDSQWEELKFEMMDIVVQ
The following text describes a protein:
Function:
Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
Sequence:
MNDYKLFRCIQCGFEYDEALGWPEDGIAAGTRWDDIPDDWSCPDCGAAKSDFEMVEVARS
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLKARMDLRTMAIGIVLSLQTALGILGNFFLLFYYLILYFNKHTLKVIYRIFIHMFISNSLINISIGIPGAFEAFGWNLVFNDFGCKLLFYIQRLARSMSISTTCLLSVFWVITISPRNYCWKEFKIKTTKFVNLSICLSWILLMLVNMLFPVYTTTKRNLENVTQMSDSQFCYSVDHDKIVYLLYIAFCMFPEVLLSILLVCSSIFMIVILYVHKKRVQHTLHAHSSLRTSTENRAVQTILVLVCTFVVFCTLSSILLGYIALLDNPSRWLMNITAIISMCFPTLGPFVIGCDFTLFRFCFTWTRNIKIP
The following text describes a protein:
Function:
Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
Subcellular Localization:
Mitochondrion membrane. Nucleus. Secreted.
Sequence:
MGSNPGSATRRLGDLGRVTSLLCSSYSAPHGVKKPALPADRTLSPSTLRRQQKAIQLQRLRRQMEGPGGPPRTLTREAMEQIRHLLREFPEEWPVPRLAQGFGVSPDVIKRVLRSQFVPTAARSLRQDRKALSRAGMGGRLQPRAALPAAPALPVLAPLLASGREAGLRGDAAGMQEPEPTGGSACPVPGPVPERHPHAGPAARNEKLGAGRRPAGEGPGPAPPASRQPRPKQRASPPSGHEGPSPASPVVSERQSEDQQGRSRNARAEDFGGKVVQKGREFFDGNGNFLYRI
The following text describes a protein:
Function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGARDGHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDVFAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMGQDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAPADPIVEDYLPIDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQALDLPVTGKYNATNAMIASYVALQEGVSEEQIRLAFQHLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLADMKELGDQSVQLHNQMILSLSPDVLDIVIFYGEDIAQLAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLGAHDQILLKGSNSMNLAKLVESLENEDK
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities; A single-strand deoxyribonuclease (ssDNase) which digests linear and circular ssDNA; has 5'-3' and 3'-5' exonuclease activity as well as a less efficient endonuclease activity. Has a minimal size requirement; 100 nucleotide ssDNA (nt) is more efficiently digested than 50 or 25 nt ssDNA, while 14 nt ssDNA is not cleaved at all. It has no activity on dsDNA or ssRNA; ssDNase activity is stimulated in the ternary Csm effector complex; binding of cognate target RNA activates the ssDNase, as the target RNA is degraded ssDNA activity decreases; When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.
Miscellaneous:
MISCELLANEOUS: Encoded in a type III-A CRISPR locus.
Domain:
The N-terminal HD domain has ssDNase activity. The C-terminal GGDEF domain has the cOA synthesis activity (By similarity).
Sequence:
MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEYELLSLFSEFHHKGHMKNDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASGEREEGQPQASRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWEELSKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRAGCTAEDVRSGRCRKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGKNLFAEARKRLKHKLTVRKLKRFGEIKGLFEHGHTERLAECPVCGRELPEGKLEPSASDPETKVCPTCNRLVSLGGNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGGRPVGEQILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMASTGTRRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIEGKFGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVVGRSRPLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGLSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLMAVRR
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRVKRRSRHRKVVKFYSTCFGFREPYKVLIDGTFVHHLLVHQLLPADDALRELLSASRAPPLLTSKCVVAELRRLGKSHSEAFDAAQLVATASCEHDKVVSAVDCILSLVGDKNPEHYFVATQDSDLRAKLREVPCVPVIYGLKNSLFIEQPSVQQRQFAQLDEEKRIHMEKSEFKKLLKASSEGKTSVNGNAPGVAEKSKFKRNRAKGPNPLSCKKKKPKPQPSAAQNQVINHHYTALSLDIRKGPKTDGEAKRKRVRKRKRSAKDSSQAETAS
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to hexanol, pentyl acetate, benzyl acetate, and 2-heptanone.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDASYFAVQRRALEIVGFDPSTPQLSLKHPIWAGILILSLISHNWPMVVYALQDLSDLTRLTDNFAVFMQGSQSTFKFLVMMAKRRRIGSLIHRLHKLNQAASATPNHLEKIERENQLDRYVARSFRNAAYGVICASAIAPMLLGLWGYVETGVFTPTTPMEFNFWLDERKPHFYWPIYVWGVLGVAAAAWLAIATDTLFSWLTHNVVIQFQLLELVLEEKDLNGGDSRLTGFVSRHRIALDLAKELSSIFGEIVFVKYMLSYLQLCMLAFRFSRSGWSAQVPFRATFLVAIIIQLSSYCYGGEYIKQQSLAIAQAVYGQINWPEMTPKKRRLWQMVIMRAQRPAKIFGFMFVVDLPLLLWVIRTAGSFLAMLRTFER
The following text describes a protein:
Function:
Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Membrane; Multi-pass membrane protein.
Sequence:
MLPIHADDKPYKPGFRIKERISGWIRLIFSDAGSRNLFLFLLLNLSMAFVELMYGIWTNSLGLISDSFHMFFDCTALLAGLAASLIARWRPNSKYPYGYVRAEIIAGFVNGLFLLFIAFFIFSEAVERMFEPPEIHHERLFLISVLGFLVNLIGIFAFQHGGSHHGHSHGGGGHGHSHGGHGHSHGGGGGHGHSHGGHGHSHGGHGHSHDSNSVFLHILADTLGSVGVIISSILIHFFGWMIADPICSMFIAVLIGLSVIPLIGESMAVLMQRQPKELDDLLPGCFHRVSQLEGVYSVQEPHFWTLCSDVYIGAVKLEVAQGADNKYILSQTHNIFAAAGVKQLYVQIDHTSI