lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, Cortical granule. Lysosome.
Sequence:
MEQRGWGLPRLLGLLALLAVQVPRSSASSYMGLWPLPLSVEMSPRLLRLSPENFHIGHDSSSTAGPSCTILQEAFRRYYDYIFGFYKWHRGPAKSHAAPELEQLLVSVVLDSQCNAFPNVSSDESCEYRVSLLVKGPVAILKANRVWGVLRGLETFSQLIYQDSYGTFTINESNIVDSPRFPHRGILIDTARHYLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPQLSNKGSYSLSHVYTPNDVRIVIEYARLRGIRVIPEFDTPGHAQSWGKGQKDLLTPCYHGHTQSGTFGPINPILNTTYSFLSKFFNEISTVFPDHFIHLGGDEVEFQCWESNPDIQKFMQQKGFGTDFKKLEVFYIQKLFNIISTVNKGSIVWQEVFDNNVKLQPGVVVQVWKYGDYAKEQSRVTAEGFPVLLSAPWYLDYISYGQDWVKYYNVEPLDFDGTSKQKTLVIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSRQDVRSSQDAYKRLTVHRCRMVRRGVAAEPLFTGYCNHEDRV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MRSIDPVSQMANATLADDDLGNYDVCLEDLQLFAQLEDLSGERLPMEMELLNPGSEYDLLELVNGALQQRNTTEHKPTDMCKPKRTPTTKRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVHER
The following text describes a protein:
Function:
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAALRASNLLGDPFALATSSIAMLGWLIAFIASIAADVQDPYPSFQWWAIAYSFCCNVGVIVVFLTDTGLTYGVAVVGYLAASLVMNSISANSMFNSKSTSSFQAAGAGFILLCMVNIVWTFYFGSAPQAKHRGFIDSFALNKENQGSYGANRPMSSAYGARPETTTSRPQMYTSAQLNGFETSSPVSGYHGGAPGETRSPSQARFTSLGGPNASNPDTVGEIPPPTEYPYKAKAIYKYEANPEDANEIGFEKGEELEVSDVSGRWWQARKANGETGIAPSNYLILL
The following text describes a protein:
Function:
Binds to sequences required for mating-type switching. Makes a simultaneous contact with both the alpha and beta domains of the switch-activating site SAS1. Also binds to replication fork barrier 1 (RFB1) located within a 78 base pair sequence near the 3' end of the rRNA coding region. This leads to replication fork blockage. It binds the consensus sequence 5'-TA[AG]GCAGNTN[CT]AACG[AC]G-3'; Has a role in chromosome organization and integrity where it is involved in chromosome segregation. Has a role in sister chromatid cohesion and condensation.
Miscellaneous:
MISCELLANEOUS: Present with 20000 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The N-terminus may contain the DNA-binding domain. Last 40 residues of the C-terminus are required for chromosome segregation.
Sequence:
MEAPKMELKSYKRKNASLSPSSSPAKAQRTHLSLEEKIKLMRLVVRHKHELVDRKTSEFYAKIARIGYEDEGLAIHTESACRNQIISIMRVYEQRLAHRQPGMKTTPEEDELDQLCDEWKARLSELQQYREKFLVGKRKCDCNDEINERLKKLTEEQQNVDMLVAKVNFLSKHLHDNEEKLMQVNAKMDEVLAENKRLQQLLDHNDLLSKLEPPSAYAPHGVNMGTNMGANMGANMNAIRGGLHSSISPNLGDH
The following text describes a protein:
Function:
Transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MVATLRLGLGSPFPSGSAVPGLQLPPQQLRNVCRASWRPQSLAQEAAARLAGRSRLRRRAEAEGRVEGWWSWRKLGRRFGGGGRPRPLPGCESPGCRRMDGASPGGGGSSGGGGSGGGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLKMCIRCLCLIGLQTVSGFFSCQITSHLLSLQVQKWMKCLPAHEGTGGSAASEDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEYLPEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSTSQSEKEDGTLSNSNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDVDTNGYEENNLATDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHENTND
The following text describes a protein:
Function:
Transcriptional repressor involved in embryonic nervous system development. Plays a role in the induction and patterning of the anterior-posterior neural axis. Involved in the establishment of floor plate differentiation from neural plate cells during gastrulation. Binds the anf1 promoter sequence to restrict expression of anf1 to the anterior of the neural plate, thereby patterning the forebrain. Can bind to the HNF-3-alpha DNA target sequence. Cooperates with t/bra in a dose-dependent manner to specify dorsal mesoderm formation, including notochord. Binds to DNA via the target sequence 5'-[GA]TAAA[TC]A-3', with 5'-GTAAATA-3' being the preferred binding site.
Subcellular Localization:
Nucleus.
Sequence:
MLNRVKLEIKDPMDWNTMYQENEMYSGIHNMTNVLPSNSFLPNDVSTVTTSMPYMSNGLPGPVTSIQGNIGSLGSMPQGMVGSLAPPPSTAAYPLGYCQGESEFQRDPRTYRRNYSHAKPPYSYISLITMAIQQAPNKMMTLNEIYQWIIDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVPRSPEKPGKGSYWTLHPESGNMFENGCYLRRQKRFKCERSKSGEGEKKVNKPGEETGGNLKENPVGYDDCSSSRSPQAAVNDGGRDSTGSSIHQACGSSPVGLSPTSEQAGTASQLMYPLGLSNDGYLGLVGEDVHLKHDPFSGRHPFSITQLMSSEQDQTYANKMEMCPTTDHLVHYSNYSSDYHNMASKNGLDMQTSSSTDNGYYANMYSRPILSSL
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRNFSMRAKVYLKPLVFFQIIDAYDRRPKGDNQVMGTLLGRNKEGHIEITNCFTVPHKEHSENKRIDLDMAYASEVLELNMFAYPNERVLGWFCTGKSVSRSASLIHDYYVRECCEGQPLHLLVDAALKNQRLSTRLYCAVEMGVPGGTKGLMFSLVPLEISNENSDLVALRCIEKQSQQQASKQMERFVPELAQVVDATRDMQHRLDLVLRYINDVLARKKKPDNVVGRSLYAALTAVPLLDSDKFRVMFNTNLRDMLMAITLSTMIKTQLEISEKLSCMQDQ
The following text describes a protein:
Function:
Plays an important role in the elongation step of protein synthesis.
Sequence:
MGVFTFVCKNGGGAWSAKQHEGELESSASSTYELQRKLVQVSLSADSSGGVQSSFSLVSPTSAVFQVIVGGGGGGGFSAGGAASSGGGAGEAAAAPKEDEKKKEESEEEEGDFGFDLFG
The following text describes a protein:
Function:
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.
Subcellular Localization:
Cytoplasm.
Sequence:
MELIPNSYCNTSDMDSALDDDICILTHEKADCMQRRDQRTPFSASSGEASVASHFALVTAYEDIKKRLKETEKENYSLKRRLRQLEEKLSGNNETSMVEKSLQEMYIERDSLLNRLNIMEKERLECTKTLNEQLQSKELELLQIRTELETHQVMKSLNKNPSDWEIEKMNNDLKMRSLEQELQLSREECRLLRAELQRKKDSAVDMNSLDECLNLIPESESSMRQAFWELKKEMSNLHLMTEVQGKVLRKLKAAVTASQKAYHTGSEQEDELLAACDVPKIPILRSSSNVPAPKPQGHIKPGFSHWTHERPIPVGGTDSEDSDSYQKTSFGESSWVMPSPPKPNETIFWEPKNDSSKTYVAHYYNAYDNFNS
The following text describes a protein:
Function:
tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. In contrast to what is usually observed in eukaryotes for which one enzyme synthesizes the whole tRNA CCA terminus, in S.pombe, cca1 specifically adds two cytidine residues to a tRNA substrate lacking this sequence while cca2 specifically adds the terminal adenosine residue thereby completing the CCA sequence.
Domain:
Cca1 contains two alpha-helices (His-81 to Thr-86 and Glu-479 to Asp-484) and a beta-sheet (His-120 to Lys-131) that are not seen in cca2, suggesting that cca1 has lost A-adding activity because this beta-sheet reduces the flexibility of the loop (Asp-122 to Glu-139) as compared to CCA- and A-adding enzymes; The ERhxxExxxhh motif (residues 231-241) has been suggested to serve to distinguish between A-adding and CC-adding proteins as A-adding enzymes have a small amino acid in the first position while CC-adding enzymes have an E in the first position.
Sequence:
MASSSSILELNETEKELSDIFLNVSKKIGQMDRKEPEVRFAGGWVRDKLLRIESHDIDVAIDCMSGFEFAQHLQSYLAQQHPDWETKVIKIDANPLKSKHLETATARIMGMDIDIVNLRHHDYTNSNSSNKLVFGTPLEDALRRDATINALFYNLKSKTVEDFTGKGLVDLSNKIIRTPLVADETFGDDPLRAVRCIRFATKYDFNIHEETIKGLKNPELHERLRSSISRERIGVEVDKMLKHCNTNRALKIIHSLGMFACIFGPLEIHTKKLQSKNIESLSLIPYAIDLFGYLQKKDVSIKNLSSSSKYIFWLAIATLPWYNWSILEKSKIKILPPILIRDSLKYSKPIMSQVENFFVHYPLIMSKINVLEKEGKLTRLGCGRLVRELGPHWRDIIDWAFFMNTLISNSDIQRLNKDEEVTWFHVLVKHIEEYGMEEAYNIQPIINGNEITRILGIRPGPHLRKMLDDSIEWRIQNPESTKEDYIAIMLEKGTSAVVDS
The following text describes a protein:
Function:
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition; (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAEPSAATQSHSISSSSFGAEPSAPGGGGSPGACPALGTKSCSSSCADSFVSSSSSQPVSLFSTSQEGLSSLCSDEPSSEIMTSSFLSSSEIHNTGLTILHGEKSHVLGSQPILAKEGKDHLDLLDMKKMEKPQGTSNNVSDSSVSLAAGVHCDRPSIPASFPEHPAFLSKKIGQVEEQIDKETKNPNGVSSREAKTALDADDRFTLLTAQKPPTEYSKVEGIYTYSLSPSKVSGDDVIEKDSPESPFEVIIDKAAFDKEFKDSYKESTDDFGSWSVHTDKESSEDISETNDKLFPLRNKEAGRYPMSALLSRQFSHTNAALEEVSRCVNDMHNFTNEILTWDLVPQVKQQTDKSSDCITKTTGLDMSEYNSEIPVVNLKTSTHQKTPVCSIDGSTPITKSTGDWAEASLQQENAITGKPVPDSLNSTKEFSIKGVQGNMQKQDDTLAELPGSPPEKCDSLGSGVATVKVVLPDDHLKDEMDWQSSALGEITEADSSGESDDTVIEDITADTSFENNKIQAEKPVSIPSAVVKTGEREIKEIPSCEREEKTSKNFEELVSDSELHQDQPDILGRSPASEAACSKVPDTNVSLEDVSEVAPEKPITTENPKLPSTVSPNVFNETEFSLNVTTSAYLESLHGKNVKHIDDSSPEDLIAAFTETRDKGIVDSERNAFKAISEKMTDFKTTPPVEVLHENESGGSEIKDIGSKYSEQSKETNGSEPLGVFPTQGTPVASLDLEQEQLTIKALKELGERQVEKSTSAQRDAELPSEEVLKQTFTFAPESWPQRSYDILERNVKNGSDLGISQKPITIRETTRVDAVSSLSKTELVKKHVLARLLTDFSVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE
The following text describes a protein:
Function:
Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSAEISETKSWTDDLPVCFYTGVGLSTNQIYKEDGYRREARECEDRSFHFKIDDHTFLYGVFNGKDGSSVADFAAQRMPAEILLGQLNDKTSPEAVKEVLNEAFLAVERSYFESIDDLLAERANLLCELPEGIKSYDAYQQFPDIVNRLRAANVRLSASASAAVALIFNGHLYVANVGDCRALLCKIDAEGVLRVMQLTVDHDLTNEDEVLRLSHMGLEVEKLQNLPGKGSHLTTRCLGNYTVKGGYKDFDLFSAAKAEPVIADAEIIGPINLDESCRFLLLTTQGLYGALEEATNSEQANKEIAQIVVEQFGSQSTITGVAQGVVDRIARIHHDHYMEDPNHVTCCQRDDITLLIRNFNFQLSAPLSASSTLRSYNTSLNAYSNDSSTMGLKFDTQLNTLSSTVGNSISETLTEASITSSTESSEQIKSNQSQNMLLDEDGRIGPYVDFTSFYQAVRKAKDEGTIPEDAIY
The following text describes a protein:
Function:
Mitogen-activated protein kinase kinase (MAPKK) that phosphorylates both MKK3 and MPK18 and regulate two separate signaling pathways involved in root microtubule functions. MAPKK which regulates abscisic acid (ABA) responses in a MAPKKK20-MKK5-MPK6 cascade involved in root growth (e.g. root cell division and elongation) and stomatal response, probably via MKK5 activation by protein phosphorylation and subsequent activation of MAPK6 by MKK5. Involved in various abiotic stresses (e.g. osmotic stress, cold and hydrogen peroxide) responses by phosphorylating and thus regulating MPK6 activity, in an ABA-independent manner.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MEWVRGETIGFGTFSTVSTATKSRNSGDFPALIAVKSTDAYGAASLSNEKSVLDSLGDCPEIIRCYGEDSTVENGEEMHNLLLEYASRGSLASYMKKLGGEGLPESTVRRHTGSVLRGLRHIHAKGFAHCDIKLANILLFNDGSVKIADFGLAMRVDGDLTALRKSVEIRGTPLYMAPECVNDNEYGSAADVWALGCAVVEMFSGKTAWSVKEGSHFMSLLIRIGVGDELPKIPEMLSEEGKDFLSKCFVKDPAKRWTAEMLLNHSFVTIDLEDDHRENFVVKVKDEDKVLMSPKCPFEFDDWDSFTLDSNPSFDSPVERLGSLVSGSIPDWSVGGSWLTVR
The following text describes a protein:
Function:
Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). Involved in kinetochore assembly and required for recovery from spindle damage.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres.
Sequence:
MEEERNSDEKENALCGRSLTAASRDGGGRMPAAPLAQGKVERGKVYSGDGVLGYLEMLEAQAHELGLKQEEKEQQEKKLDRLKARVQELRARRDELRAKVELQEKRLLDKEGVMTDPAQPSAQTVLEWKVKSLKAMLQVFYLTGISGKLTKQGVCFCISTAYEGTYLDSYYVDLLIKPLVKIQRHSVPVFIPLEQIAKKYLQTDIRRFLSVLSDHLNAYVGRRRQADQLEEHFSDHIDGTLQRNSLCNLLVFNYTVSSNSKTFPFNVRLLYGDLCCSLPTEAIISCTPGTLPLLAEMAAAHSNAFRHMALHKAFDSLINAKESQN
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTTNTKRAYKLQEFVAHSSNVNCLKIGRKTSRVLVTGGDDHKVNLWAIGKPNSILSLSGHTSAVESVNFDSTEVFVAAGAASGTIKLWDLEEAKIVRTLTGHRSNCMSVDFHPFGEFFASGSLDTNLKIWDIRRKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNVVKLWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSSDKTVKFWDLETFELIGSTGPETTGVRSMTFNPDGRSLLCGLHESLKRLEPYATGTSTKLNGHSELKSSSSSTMPLQNDSGSRANIGRLSVLQNSENNIKSSTGRLSVSQNSDSALKETKSTTSSGLVPVTPQRAGNGSSTKTVGNSTFASSGTNLKRGSLKSNNSSSLQNFSKIDVVPVIIPRTSSGPELATDSRSDAADVGPVLSKSGRRIEIANDSRKESSDVAAAVVPRTNSRTEMASDSAPVVGPRANLRMEVSADSAPIVPKSGRRLESSVESRKESTDVASAAAPKTSSRMEVAPDSAPLLSKAGRRVESATDSRKESADVAPVVPRTTSRMEMAPDSRREISAGRMSPFRVQSRYSELRKLNNAKADADKVDAGSKNSETDDFTCQIYLPRRNGVVQSGISEETREDAKPGVIDRMGFPSSAEPNTHRSENYVSRMRKPRDNCYIEVSRAGRTRPTASNWESRDQSPGNEEPTTSNSSSMAPTGRLYSSRGSSQAAETPTIASDEDVLSVLMEQHELFLSSTRSRLTKLQIVHQMWQRNDIRGIIAAMEKMSDHAVSADVASVLMEKSETITLDLCTVILPVLTDLLESKTDRHLGVSLELLVKLVRTFGSVIHSTVSAGPSSVGVDLQAEQRRERCNLCFIELEKVKNKLPFLSRRKGAVANTAQELSLVFQEVM
The following text describes a protein:
Function:
Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.
Sequence:
MEFLGRTYLVNDKATKMYAFTLDSLELQQKPLNKDQCRGEKPEELEAGAIHHCHHYLKATEDRAQEQTCAKWKLRAASGGCLVFMIAEVVGGHVAGSLAVITDAAHLLIDLTSFLLSLFSLCLSSKPPSKRLTFGWRRADPWALLSILCIWVVTGVLVYLACECLLYPNYQIQATLMIIVSSCAVAANTILSVILHQKCPAHNHKEVQANASVRAAFVHTLGDLFQSIGVLTSALIIYFKPEYKMADPICTFVFSGLVLASTVTLLKDFSILLMEGRSDFRIISSIYNGVKELISAADGVASVQFASPISLSSLSTAASRESQVVRREIEKVLSSRFPDPACLLSEDPQD
The following text describes a protein:
Function:
Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.
Domain:
The Tyr-Pro-Ile-Thr-Pro (YPITP) motif is important for the turnover of the reaction, presumably through its flexibility and mobility.
Sequence:
MVDISLIIGGPQGGGIESAGQIAIKSMVLLGYEVLGSREYHSNIMGAHSYYHLRVQQHRPRSLKLPVDGVLALDAESVFTHFRDVRPGGILVYDPGTKSTRVDAIQPMAGPLKKRLKSLFDSRGMQPVVESAVKLAEEAGARIVGLPLKEMLKTLSERTGAPVARVSRALNTLGLASMLYMLGVPVEYIEKAISLQFAGKEKVINMNVEAVRIAVDYVREAFGEPESRLPPGPRRGQTMMVATGNDLVAMGKIVGGLGVITYYPITPSSDEALYVEKHSYISIDGPLAEKLGYDKIAVAIVQMEDELASINAVLGAAAAGARASTTTSGPGFSLMNEAVSLAVEAEIPVVVTLWMRAGPSTGMPTRTGQQDLLHSIFSGHGDAPKIVLASGDHVEAFYDAIKAFNWAEEFQTPVIHLLDKYLASSMVSLAREDLDPSKVPITRGKLLDNPPADYRRYEVVEDGISPRARLGSATMVITGLEHDEYGYATEDPVMREIMMFKRERKFKVIEERIPDEEKAVLHGDSEASVALVSFGSTKQPILEALEMLRDEGVRARFAQVRLLYPFPGRLVEEMLEGVEKVIMVEQNLLGQLAMLLRAHTSIKPDSSIVKINGRPLYSFEVAGAVKRILETGEERVVVSHGS
The following text describes a protein:
Function:
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MGFGQAVVGPPGSGKTTYCWGLQQYFRAISRPILVINLDPAADQLSYEAAIDIRDLIRLEEVMEFHRLGPNGSILFCLEFLEKNFDWFAEKLSQLTSPSSSSESSKGPASPASLAQEIDYIVLDLPGQVEISTDHESLKNVLHKLEKLDWRLAVVQLTDSTHIVDPIKYISIVLLNLKTMLHLGLPQVNVLTKIDLLKHFNEDFKLKLDFYTDVQDLSYLLPLLENQISPKFANLNKAIIELIEDFNLVGFESLCVEDKTSMTKLILTIDKALGYYPSHRPSLADPRGVPKTTTSSEGAQVVGEPDAMAIEAQLGPSSGLLTEIQERWIDYPELYDHFQRQLWADESQLVQQRASQLSQIHAIQKNKQSP
The following text describes a protein:
Function:
Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFVSKSPPIVNSASPTGQVNPMEVEKANKLLEINRLILWKCLELQHIKTAQNSTLEQRALSTELFNSYIQRLKANLAFVVSIASPRQMQVLTPPLSCPESLPQLEPLYKELRQYFQIAQTSTLSYPPSNGDSSSYANGTDLHGNTGTMQQEEKANPSLTRSDSVSSGSYITMQGANSLKAQQDLLNSFTGAPSNNSHNIPDPNLSQTFSATSMGPPNNNYSKFRTDNYLARSSNRSGTPNIQNEQSRFFDSQQAQVQARALMQRYQQGMEFNK
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters.
Sequence:
MALQADFDRAAEDVRKLKARPDDGELKELYGLYKQAIVGDINIACPGMLDLKGKAKWEAWNLKKGLSTEDATSAYISKAKELIEKYGI
The following text describes a protein:
Function:
High-affinity permease involved in the transport of the cationic amino acids (e.g. arginine, and, to a lower extent, citrulline and glutamate). Transport mostly basic amino acids, and, to a lower extent neutral and acidic amino acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEGEERGYWRWSKRDFFPEESFQSFGSYRAALSQTCSRFKNRLVSRSDDENERFELKKQSEHEMKRCLTWWDLVWFGFGSVIGAGIFVLTGQEAHEQAGPAIVLSYVVSGLSAMLSVFCYTEFAVEIPVAGGSFAYLRIELGDFAAFITAGNILLESIVGTAAVARAWTSYFATLLNRSPNALRIKTDLSSGFNLLDPIAVVVIAASATIASISTRKTSLLNWIASAINTLVIFFVIIAGFIHADTSNLTPFLPFGPEGVFRAAAVVYFAYGGFDSIATMAEETKNPSRDIPIGLLGSMSIITVIYCLMALSLSMMQKYTDIDPNAAYSVAFQSVGMKWGKYLVALGALKGMTTVLLVGALGQARYVTHIARTHMIPPIFALVHPKTGTPINANLLVAIPSALIAFFSGLDVLASLLSISTLFIFTMMPIALLVRRYYVRQDTPRVHLIKLITCLLFVVVSSMGTSAYWGMQRKGSWIGYTVTVPFWFLGTLGIVFFVPQQRTPKVWGVPLVPWLPCLSIATNIFLMGSLGAMAFVRFGVCTLAMLLYYFLLGLHATFDMAHQQIVPRT
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
KEDVTLSKPIDTGLTDHEVESMVEQTAMEVLIQEGLQTLRKRGQEAIAAQHKATEAVLHHTDQLKHALEDVEVVSMKDLSKTILSSQKEAEDAITGAQEAQVKVNEEVEKFHILIKEAETAGAKEAGVRASEEAAKVSYGVLNATAELQKAKAQDMVLGEYQKFFDESRAVLRKELEEVMPGAAMSDKEQKAKGGKTVLLAYARKRLEHLKQELAKHRQEEQKRLQQILSVQREEDNKLADIRLKQEKDKMMAEMDVALRKKESEMAAVFESDVRQQLRRQAAAYSDHLAEVLRVQAAELQERHREELEKKSNEEHQAFNAKLTAAFSRLRGVESAIDGRAEIEKTNKRSQELWLACQALTSAIDRGYQKRRPLNHEVSAVYDCSPEDPVVNTVLEAIPPEALQKGVYNEDNLTARFNQVRRQCRRVAMVGEDSAGPWTFLLSYLQSFFIFDKFDPRTDGELVDAEELDTFGLLARADYYIKRGDLELGARLVNQLTGEARKLAYDWLKETRILLETRQAVRLLSSYAAAAAMG
The following text describes a protein:
Function:
Can also synthesize a number of adenyl dinucleotides (in particular AppppA). These dinucleotides have been proposed to act as modulators of the heat-shock response and stress response.
Miscellaneous:
MISCELLANEOUS: There are two lysyl-tRNA ligases in E.coli: lysS is expressed constitutively, while lysU is heat inducible.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEQETRGANEAIDFNDELRNRREKLAALRQQGVAFPNDFRRDHTSDQLHEEFDAKDNQELESLNIEVSVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDSLPEGVYNDQFKKWDLGDIIGARGTLFKTQTGELSIHCTELRLLTKALRPLPDKFHGLQDQEVRYRQRYLDLIANDKSRQTFVVRSKILAAIRQFMVARGFMEVETPMMQVIPGGASARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYHDLIELTESLFRTLAQEVLGTTKVTYGEHVFDFGKPFEKLTMREAIKKYRPETDMADLDNFDAAKALAESIGITVEKSWGLGRIVTEIFDEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAERFQEQVNAKAAGDDEAMFYDEDYVTALEYGLPPTAGLGIGIDRMIMLFTNSHTIRDVILFPAMRPQK
The following text describes a protein:
Function:
Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis (By similarity).
Subcellular Localization:
Mitochondrion. Peroxisome membrane; Peripheral membrane protein.
Sequence:
MAVIFENPQYVHVLRMLNSMPARDKTFRALQFVAKLLSWHLFYGGSSLSTVNKWKKLESNISFSRKLFSIGKVLDYICKVYFDSLKLQNPLSGNKSALPTISFTKDVAFAGYATAELIGWFNKTELMPCSHSKQISTIGKQCLAVALLSSCLAGCYELQQNSKKIKSATQEASEKDSTSLQTLQKERKEILFFALQNALDATIPLAELDILKVNDGFVAAAGITTSLMSVYKTWIGSY
The following text describes a protein:
Function:
Transcription factor that specifically regulates the expression of the hxn gene cluster that mediates the degradation of nicotinate and related metabolites.
Subcellular Localization:
Nucleus.
Sequence:
MKAKMKKHACTYPGCSKAFTRAEHLRRHSLNHETISNSQGYTCQRCMTHFSRADLLSRHLDRHAKKDAEAGGFGKGVLETRKRMRRAEDGSIVLRPPKRPSRHQQKTGPPVGAPLSSSGSVSAGSGRSSRSPDVSLHAAQAPVSPPRSASDPVSVSGVSIDDDGTDPDPMLAPMMPGGPFEPYVEPIPGQFDAADGSWGGFDALGDGMMLDTATDFNLPFAATGNYNWLFDVSSLDDAFHHLELPLGPDLVPFANSHGNYASVNTMELSGAGAENVQDSMLNLDLDIDLNGLPAGFVHDQGPDGSSASVLLQAASFVERGNINGSDPKRDFPDLDWMAGAPPIESTVPLRPQLSEDARRGILTLIAQSPPVDIHGQPLNLDSPLLSLSALQSYSDLFFSRFNTTYPLIHSATFDPNKTEPVFLASILSMGATYSSREAHQLAVGIHDGLRNQLFCHGAFSPQPDELWVLQAMLLIDCFGKMRAGPKQRERAQLFHCVLIKLIRRSTCCSIRADTHSDPGLGGLELEDAWKRAMDAEQRKRLAFQCFMWDTEHSVLFSQSLCMSAFEIRSSLPCSPAAWEAHTAEEWSRHASRDTEHAFLPVLKGYITPGSVSRPRDLNRFSRMVVLHGLMSISADLKRRDQTTLRAETPERVGAWTPRMGRAYDLWKADFDADCLNMKLGPVQVSADETRRFTSLKAAAMALYRAASLALHVEVLDLQIAAGASHILGRVVKQHDRERSRVMLSRWLSGPSPAATTASRHAAALLQDAVLSLHDWDQTDAFHFPWCLYLATLTVWAFHAREGCVPKPTDLSSLIVAMTTSNAADLEGLAGQYDTRPLIRAMAQQLATVRWAVVHDAMKVLLNLGV