lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a receptor binding protein (RBP) and probably mediates the attachment to the host capsular exopolysaccharides (Probable). Displays a depolymerase activity that specifically degrades the K11-type polysaccharides of Klebsiella pneumoniae capsule.
Subcellular Localization:
Virion. Note=Tail appendage.
Sequence:
MANKLTQPKGSISKETNKEAIARLFGIKKTAVGYISTSVLIDPYTILYDESTETCWYRGTATGTPISWIITNGSLTLQTTSGQFALIKTQVDINLRQEITGEVGYSNIGKVSSVTSLRSIEPTTNGQQIILNQINSTLGTTTGGIFCYDSSDVTSIDDGYTVIVTATGKRWKRPENYIDMAWFGALNPAVDFSDAWDAAVAIVSNYVSNVGFYGRKAIYLKAGTYKPSRQLDIPSYVSVVAIGNVTIDGSGMPDNSYVIRIINKVSGISTTYHKGWNLGSIGGTFRVLGNTLDGNVDGIFVGNTSNMSDVRNVILYGVSIGGVRYGLTFGSINTYLFTATDCHIESTIIGIYVPNTTSSNSGERMTFNDCTIGGSRTNHIQISQPGFDVNFTNCSFDFTSGNVFYGTSTWGYSKVSFTSCHMEGYNGLLLSAESPQSSSVGSNRSIIMNNITNLSRLRSNTTGTNSSSRLHIDAKSTPVYINGLDQRHEVTPYLEDCLMCSDETILYINGYIKDPYFQLPSNTMILNKGYNMGDEVVGTVVNSTATLDALTRYTCVDRNAMSATVITGGTAGTQLQVTGAGGYFNLATKSFIPVTVKNRLGLYLSLSALDSTGNIQCTFSVAWYDVNDNLISTSSASSINMRTVFNDTTLPNYSDGNSRYIATPSRTFNAPVGAVKCKPRWQVSGFTGNINVSRMVSFILAG
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MNIQNIYKEPNLLNRIFLNEKGYDVVTILRYIVLKIDQTNHNLDDSIKQVFNETTDPIDYRDFLLNSFVCLKAEIDTNTAQNNQNNQNNNNNNQNNNQNNNQNNNDNNNKQQTTLKRKIEQQKIPNNSFYKLLSLVKQIESKNVISLIGYTGETYQNTPIGYILTSPSFKRISERHFEILEDIFKNHYLFTRSTSNRNIYIQISGLPVSFFAKKNRYLQIQQQQQQQQQQHQQQQQQQQQQQQQNQQKQKILNKKENDYEKIESKTRLPSWIRKRNKKKEQQQLNKENQIKKRNEEQREKQTNLNKTNYKAIAKPSYRINNFIKDDEENERDNQIVHNHILYSMTPSSTFLPNKISKLLNNKQLIINGKISLNYTKKLLWYLLSQPLSSCISKQSKHNQKSLIDILPKKPNQIRIQSSFKPTLPIFSNIFQKLNNTKSYQHILDSLYTNYHFGSSSNNNNNNSTKSINIESTQIDLKSLINNNCPIDLVYRFLITITNRLFCKNKVWGSEYNQKCFNQGLIIFLNQTSNKKLKFNSFCKRFNLNQFLFGTNCSIIYFKRFMWWLFEEIIPSIIRNYFYCTESTDSLKLLYFRKVDWFKLAGIQSQNLSFKIYSEIYFVNKQTIENRKFGISSLRFIPKTSNLRPIVNSKNNNSTLPIFNENNSTISMVDFPESINDSLATFAFPILKFELLTNNNNNNNNNNNYNNNNLIGSSIFTKSDIYLKFKSIREEYEIFLNNNNNSTSSSSPSSSSSQGLKKKLYFMSIDISKCYDNIDQKKLFQILNEKVFLNEKYLVQNIVNFKMKKKSEYSPFINTTFFVSSLNNIPTLDESIRIHKNNQSETIIYDSKYQQIIEKNQLLHLFHSHIFNHYIRYSSKLFHQVVGIGQGSLCSPHLCSLLLGDLENEILLPLLNNNKNNNNNNNKNNNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLEFNFLVRFIDDYLYVSTEIDNLKSFKNLFHNGITEYGVKANQSKTKYYYSDDENSGLIKRGDGDDNDQLFIAWCGYLINCKTFEVQKDYSRLSKKVNNDNFTFFNFNDNDVETNEQIEWRNKLFKFLISKLSDKAQPILLDLTINSLPTIFLNIYQVILFCAIKFHCWVNEFYWNLNFNANLILSQVISRISNFLFNQILKVNNNNKNNNNETQQQQQQFNFIILFEINWLTLYAFKRILKKKPTNYIQLIKQLKNRLNQLNNSSKTSYIQLKYKKTINDNLSIDILNIIY
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.
Sequence:
MSSNSVAKIAEYLILSLPQSTHAHEWLEQSLNNGKQPLYNLKIPDFQSGTLDSLVQESEELNKIDHQLGSSVNKVVEILNSINPQTSSGSSSSSSRIVQSRSIFDYIENFQWNSSKYRLDKPISQLVKMISQEAITLDNDVRTSYQSYQSAKSNFLAADRKKNGDLSIKSLHEIVKPEQFVLDSEHLTTILIAVPNNLLDDFHKNYETLTSFVIPRSAELIAKDQEFHLFTVTLFKKYQQEFINNAREHRWHPRTDFTYSEEILNELRKEFDLTQATELKLKNDLIRLTKTAYSDIMANWFHIKIIRTYVEAVLKYGLPPQFDNYLIKFNESNLKNVDKAKKELIAKFNYLGGNGYTTGNNNSSNLHEYASLVDTEYQPFVLYELEIV
The following text describes a protein:
Function:
Chromatin remodeling factor that binds to methylated histone (e.g. H3K4me2/3) to prevent their acetylation (e.g. H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulate the transcription of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MAKTRPGVAFSSKIKLGKKDIKILGREILLGNVIVEVGFFTVGDCVLMRPSDAGKAPYVARVEKIEADARNNVKVHCRWYYCPEESHGGRRQLHGAKELFLSDHFDVQSAHTIEGKCIVHTFKNYTRLENVGVEDYYCIFDYKAATGAFTPDRVAVYYKCEMPYNSDELMELLLCHYRVHLACVGVTIEEAKKLEHFVCVECSSDEDGVKRFQNGFASSTTNDLKPSAEKMIDVRASYEL
The following text describes a protein:
Function:
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MNEQKKENINIKNISNHNNSDGKEKSSIPSKNGSWYYPSQKQFYNTTKKKGYSFSQEDLNMALKIHNAVNEETWNKIMKKEQKYFDICKEQKLIKFVGYPTKLSIKAFMLTLIGYNKPFDRHEWYIDRCGNTIKYIIDYYDGKKEKNSAVSIYIDARPQLNHQNAIDNVKIIYIKICRFLNNLF
The following text describes a protein:
Function:
Relaxes both positive and negative supercoils and exhibits a strong decatenase and unknotting activity; it cannot introduce DNA supercoils. ATP is absolutely required for DNA cleavage; the nonhydrolyzable analog AMP-PNP generates nicked or linear products from a supercoiled dsDNA substrate. Generates staggered two-nucleotide long 5' overhangs. The enzyme is covalently attached transiently to the 5'-ends of the cleaved strands.
Sequence:
MSSEFISKVDKEARRKAANILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLRRNFLDLNEAKRFMQTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIEGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSKEKGKVVGNLRIRSGNDVIDLSKTGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRATRRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMGDIFGNSRKKPYLSEAERKNYIIKAKDADIKRAEEIKNYEWFKTKAWQEEINTFLQRKAKLEIEAMASKGLKFLAFQYIPEKITNKDYIA
The following text describes a protein:
Function:
Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLPFLKAPADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQTPREA
The following text describes a protein:
Function:
Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A.Z into the genome to regulate gene expression. Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment. Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone variant H2AZ1 to chromatin and induces muscle-specific gene expression (By similarity). Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition. Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription. Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72. Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis. Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters. During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex. In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (By similarity). Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (By similarity). Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (By similarity). Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase. Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1. Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVEKKPAVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSASEGPNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV
The following text describes a protein:
Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MTQGESQSQKRWWRSWYPTQPQVCNQYSPLLTQKDGCSKAPREEITSVPAFLFQLCGCSINRSPKNPEQKIIKRVIALEGDIIKTMGHKNRFVKVPRGHIWVEGDHHGHSFDSNTFGPVSLGLLHAQATHILWPPQRWQKLYPILPPDRVPIHSQKD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
KKKYDAPSPAPSIRSSSRLAAKPRRTHCLTARVRCTPIQPDCLPTAEGGDRSGKPAVSSETSQKAASAAPPAEDALLCHRGVRERRYSCSSCGKRFFQVGHLKKHQFNFLTCKALSLQLSHRGERPFSCSHCEKTYGLKRDLKEHMVLHTGEKPYICEQCGKAFARNLECHLRIHSGVKPFSCSECNQSFSQKPDLQRHMLSHTGGGFLCSYCGKSLRDPHSLRSHERLEICSAILACCAIHPHK
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Subcellular Localization:
Cytoplasm. Late endosome membrane; Peripheral membrane protein.
Sequence:
MTELEFSADNAAPVIPITAICIVADKNKAPRGFLPIIKCQDDQTEADLWRDGFFTINRQVRYICTSTEIPDSNIKTPVQVITNLIIVRESDPIPHGYVAIDYTADSREKSLRKKYVCIRTEPRDRVVDAIGEIIILGKTKKVPRDYTSAGDIDSLLICYKVISIPQTYGIQTSNSTSNIESQAAGGLYPGLPNLSNSTPANLDVTGSSSNSAFTMKNAGAPRVKAIDGIDFKVNPMFVNSSGSNNSSQLPDLSQFNDLDRLDDKYNYSYATEHAVLS
The following text describes a protein:
Function:
Binds (in a non-immune fashion) to the Fc portion of human IgA and IgG; binding occurs on the cell surface. Confers the ability to survive exposure to human serum exposure. Binds to the Fc portion of human IgG, IgA and to whole mouse antibodies also via Fc. Upon overexpression cells acquire an extra cell surface layer that forms a zipper-like contact between cells; cells autoagglutinate and form biofilm more readily, suggesting it may play a role in defense against a host.
Miscellaneous:
MISCELLANEOUS: Encoded in a prophage region of strain ECOR 9, upon UV treatment bacteriophage containing this gene can be isolated.
Subcellular Localization:
Cell surface. Cell outer membrane; Multi-pass membrane protein. Note=The C-terminal translocator domain is localized in the outer membrane and the passenger domain is at the cell surface.
Domain:
The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space (By similarity). Then, trimerization and insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface. The crystallized passenger domain (residues 161-440) is an entwined, elongated trimer with a head domain, a neck and 2 extended coiled-coil regions of differing handedness separated by a saddle region. There are a number of cavities in the first (right-handed, RHcc) coiled-coil domain that may allow bending of the extended structure. Smaller cavities in the second (left-handed, LHcc) coiled-coil bind 5 Cl(-) and one water molecule. The Fc portion of IgG has been modeled to bind to the LHcc domain just under the saddle; up to 3 Fc can bind to the trimer.
Sequence:
MSKKFTMTLLSSSLAGLLVMSGGVSAQNGTYSVLQDDSQKSGPVKYGSTYEVVKTVDNGNFRYEVKEKKNDKRTLFKFDSEGNVTVKGKGITHTLHDPALKDFARTAEGKKNEQNGNTPPHKLTDSAVRGVYNKVYGLEKTEITGFSVEDGENGKVSLGSDAKASGEFSVAVGNGARATEKASTAVGSWAAADGKQSTALGVGTYAYANASTALGSVAFVDNTATYGTAAGNRAKVDKDATEGTALGAKATVTNKNSVALGANSVTTRDNEVYIGYKTGTESDKTYGTRVLGGLSDGTRNSDAATVGQLNRKVGGVYDDVKARITVESEKQKKYTDQKTSEVNEKVEARTTVGVDSDGKLTRAEGATKTIAVNDGLVALSGRTDRIDYAVGAIDGRVTRNTQSIEKNSKAIAANTRTLQQHSARLDSQQRQINENHKEMKRAAAQSAALTGLFQPYSVGKFNATAAVGGYSDQQALAVGVGYRFNEQTAAKAGVAFSDGDASWNVGVNFEF
The following text describes a protein:
Function:
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
Subcellular Localization:
Peroxisome.
Sequence:
MPADEAQAPTQTEVYDRLKWNGWGVEDVQMQIDDENPLWVRHVDGKPIKNLLEFLYQEISGGVGPKEIPPLSPSIPLEKALAKLNKANINEAFMKDISAVLEKSQIRPDGKSRLCHIAGKNYRDLWRVRKGMVEHAPDCILLPNSHKDCVEIMRLAHKHNVVVIPFGGGTNVTGGVEADPFERARMIISVDMRRMNRMISIDRESRLATFETGVLGPDLDAQLFRHGFMLGHDPDSYIYSTLGGWIGARGSGAMSNQYGDIEDMVVAVKVATPTGIIETPTTSRTCGVDLNGLFIGSEGSFGIITEATIKLETIPETKLYEGYLFPTFEAGFSAFYTCTAKGIHPCTMRLYDEDDFRMSMAMSTTKHSFFQRLVSMGVKSFLERYRGWNLRRISLVIVGFEGTPDRVKFQRSETAAVFKQYGGVGVGRSAGATWQDKKYDLPYIRDFALSLSHWADVFETSVLYSQAIPCWRAVKAAVRQVWKEHGHRGWIGCHTAHQYKYGCCLYFTFASAQKDDMDMKIFLAIKKRATEAMLAHTGNLTHHHGIGYEHVPWMSRYMGPDALDLLFAVKQKVDPKNICNPGKLLPSPPRENESAAALKARQQRELMFDKMGVPGAVASHI
The following text describes a protein:
Function:
Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.
Sequence:
MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPLGSTDESNLNQDLVWKASREYVQVLKKNYMI
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MQGRRLVEMARKWLGALSKGMICHEVEAIAMEGLQVVQARKGFILCHFLVPRRLSDRDGNWHVGAMATLIDNVGGAAIWSSVGNVKSTVNLNISYYSTAKIQEEVEIEAKVVAEKETLVAVVVEIRKRSNGELVALGKQWMATGMTTVNITEFSKL
The following text describes a protein:
Function:
Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
Sequence:
MFLMPTSSELNSGQNFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTHFSDSFSFINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQEENKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEYKEEEEDQDIQGEISHPDGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQVMPDQRVIYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQEESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYRSGRIRVKDKEGNVLMDTEL
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Sequence:
MELIVDERGSFIGKHQGRLRVTKDNERQKEVPIMHLRQVIIAGGGIAISSDAIRACSEEGIPIHFISSNGTPQASLYSAGLTGTVLTRRAQLRAYDGPAGVALARAFTLGKLGNQANLLRYVAKNRKGTAPEIYELLMATAAEVVDYQIAVERLHGETVDDIRDALMGIEGRYAARYWQAIGSLIPPALNWPGRETRGASDPFNQVLNYGYGVLYGQVEHAIVLAGLDPYAGLLHADRPGKPSLVLDLIEEFRQAVVDRTLLGQITRGWQIGREEDGRLDQPTRERIATKVLERLETTEPYEGKRQPLRHILQCQARHIATYVRGERESYTPFIMGW
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit; With S5 and S12 plays an important role in translational accuracy.
Sequence:
MARYCGPKNRIARRFGANIFGRGRNPLLRKPNPPGQHGMQRKKKSDYGLQLEEKQKLKACYGMILEKQLVKAYKEVVNKQGNVAQMFLEKFECRLDNIVYRLGFAKTIFAAQQLVSHGHVLVNGKKVDRRSFFVRPGMQISLKEKSKRLAIVTESLENKDQSSLPAYLSLDKAAFKGELVVAPELDQIASQLPLPVNVSVICEFLSHRT
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
VTMLSVKPGPRFTVPDWQTSNFLLSSNAERQRDAAYQIRQEARTLRNETNSQTKWDEHDNRTRLEERMESIKRWKEALDKCLAEIDAEIDALSKVKEAAERALQAKGLPLDVAIECLTLRESRRDIDVVKDSVEDELHKEVELIDGIKKTLQGRIDEAFEQLCLLQEARQQLNFDHRNKMEALEIDRVCHSLNVNSPNISLKVNPTRVPTGSTTPQQWDEFSQYNKDRAEAEIKASMELREAIALTIAGTDNELEAQRVMAEFAFRKRMREMEKAYDELRWQEKNILEEISGMEEDIRRLEEDLRRKMDNLKLAHTRLETRTYRPNVDLCRDQVQYGLTDEVHQLEGTVAVLKQKLAQSKDALDALYKHLARVQADIICKANSLQLDNKCMDTRRKLTVPAEKYVPEMDTFNRTTNRTLPPVKSYQLELA
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSSSSNPVSQFNNISLGGRISGTRGILKFTTNNITWKSENGKIETVSSSDIKRANWARVTPRIFQLILSIKGGATVKFDGFKEQDYEVVRKYLSDQYNVSPLEIIELSSKGCNWGEVKVNGPMIQFTTDHGKVGFEFPISEVSQSVIGANNKNELTLEFHHDKAMDDDDETMVEMRFFTPIRPSKEGEEGGKEKKVGEDGEEDEEDEEDAEKEEEISALEQFQQTIMNKSDMVSNVGKSLVVFSAIQFLTPRGRIDIEMYPTFLKLHGKTHDYKVPYESISRLFQFFRPDQKHIFFIISLDPPIRQGQTKYAHLVIQFQAEENIHLELNLTDELQQKFKDQLSPIMNGNANALICKILKALTGKKITIPGNFQSDSGANSIKCSLKANEGYLYPLERCFFFVHKPPTYIKFEDISNIEFARYGAPSVRGGSNRTFDLSINLKNSTSIQFVNIQREEYPSLFNFLKEKKLSILNPVTTGPAMIIDDDDSDDDDYEPSESGSESDEGSASDESEEESEEDKKAKKKQKK