lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Subcellular Localization:
Nucleus.
Sequence:
MELGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYETICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKNLRKKDKEGPECPPTVVVKEELGGDVKMESASPKTFLEGKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEAEACVSRALGLVSGQEAGPDRVAGVQMTLAELQDFLGQMNNLPCAMHQIGDVKGILEQVEAYQTEAREALVSQPSSPGLLQSLLERGQQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAIMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIHEAENIPVHLPNIQSLKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEIVAFKEGEQKEKEGILQLRRTNSAKPSPLASLTTNSSTASICVCGQVPAGVGALQCDLCQDWFHGRCVTVPRLLSSQRSSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLGRLAELRQRLQAESKPEESLAYSSDGGDGTGNMPKVQGLLENGDSVTSPEKVATEEGSDLELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLKRVQTLLELEKAERHGSRTRGRALERRRRRKVDRGGEPDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEVPPVPFPNNGSPSTQEDQDGLEPVLDAGSDTSAPFSTLTSRLLMSCPQQPSLQQL
The following text describes a protein:
Function:
Promotes maintenance and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3. Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability. Mediates the proteasomal degradation of UHRF1. Is required for the establishment of the blastocyst.
Sequence:
MVSAPPTLQDQAFRSLVRNEVLTVSDAECLIREFFPPLFKEASTQKKPKTIMILVEHWPYPCLHVGLLIDKPNFQIFQAILDGVDTWLKRKYRPRMGRLKKVDFRDAQHHASLDMQDEREGRDYLVGTLPKKQIVEDHSRTRKERLKLFHDLSFMSSLHEDKHQTLLLEWAKERTSFLHLCCEKLEIGAVEVSKVRNVLKFLQPELIKELKLNTVGNLSKLAKFVPFIRKMRNLQKLMLVRTFGTRTFTQEEKQNISKIISLFCKLSCLRHLTIDDVYFLTDQMKELLRCLEAPLVSLKITLCQLSQSDLESFAQRWNYSQLKHLCLRGVTLTNLDVTPLRDFLKRVAANLQTLDLEDCRMDDSHFRTLLPALIKCTQLTSINLYDNDISEDVLENFLHRTTNLSQLTTEMYPAPSEVYNESNYVIVEIFIQICSELMNKLMEVRQANSVCFGSSSCYDCDNRYLYEDDGDVTLCLCQE
The following text describes a protein:
Function:
Binds lactose. May participate in the apoptosis of adipocytes.
Subcellular Localization:
Nucleus.
Domain:
Contains two homologous but distinct carbohydrate-binding domains.
Sequence:
MSTDEHLDPIPDSFILQPPVFHPVIPYGTTIFGGLYAGKMVTLQGVVPLHARRFQVDFQCGCCLHPQPDVAFRFSPRFYTVKPHVICNTHQGGLWQKEIRWPGVALQRGDSFLILFLFENEEVKVSVNGQHFLHYRYRLPLSRVDTLDISGDILVKAVGFLNINPFVEGSREYPVGYPFLLYSPRLEVPCSRALPRGLWPGQVIVVRGLVLKEPKDFTLSLKDGTTHVPVTLRASFTDRTLAWVSSWGRKKLISAPFLFHPQRFFEVLLLCQEGGLKLALNGQGLGATSLDQKALEQLRELRISGNVHLYCVHC
The following text describes a protein:
Function:
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue.
Subcellular Localization:
Secreted.
Sequence:
MRCWVLAVVTAVLWSQCIPLGWAEGRKVPKRLKEGAPQHTEAFNTTLSNSEELDGSPKQVGENQRVDPLGSWMDFVKRPVGNFPGKCRKRKRPLPGPPGPPGPPGPQGPPGAPGAEVTQEVLLREFKEMIKEATERRAAVDRPSEPSQLPTALITLEGMTSYRRIEEAFHCKLKGPVVVDKKTLAELQNFQTPPAKGAFLRGTGMDQSTGRFTAPVTGIYQFSANVHIDHTEVKRSKSQLRARDNVRVLICIESLCHRYTSLEMIVGLESNSKIFTVSVHGLLELQAGQYTSIFVDNAAGASITIQNGSDFMGMLLGV
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope. Plays an important role during embryogenesis and chloroplast biogenesis.
Subcellular Localization:
Plastid, chloroplast inner membrane.
Sequence:
MANEELTESQQQEDPSQQLPNADEEKGSDSDSNSDSDASSQSSGDDFYISESENEAEGDNTIFNYVRPSDIPPDPNANPETNIRRFNRVLDGKRVKRMQEEEEDKYTFYEDLFDFPRDPERWKEQDLREIWADGPLEMTKPGWDPAWADEDDWDVVNDEIQEGRDPGIQPFYVPYRKPYPAIPDNHYDIENAKGVVEELDRIEEFLQWVSYIFPDGSSYEGTVWDDLAQGKGVYIAENGLVRYEGEWLQNDMEGHGVIDVDIPDIEPIPGSKLEAKMRAEGRIIKRDYMTPEDRKWLEMDVEDSVALTDGNFQVPFYENEEWVTQFGEKPEKGRYRYAGQWKHSRMHGCGVYEVNERILYGRFYFGELLEEEHGCTVDICALHSGLAEVAAAKARMFVNKPDGMIREERGPYGDPQHPYFYEEDDVWMAPGFINQFYEVPEYWETYVGEVDQEREMWLNSFYKAPLRLPMPAELEHWWENVEVTPEFVLLNKEPEPDPNDPSKLVQKEDPVILHTPTGRIINYVEDEKHGIRLFWQPPLEEGEEVDPSKVEFLPLGFDEFYGKEVVVKKEHPIKSFVLGIEKSVKPMLDGLEKWTEEKKKAYEERKEMIQQELELVEAEICLEEAIEDMDEELKKKEQEEEKKTEMGLTEEDEDVLVPVYKEEKVVTAKEKIQENKQEEKYKDDDDEDDDDGDDDDDDDDDDDLGPSSFGSADKGRRNSPFSSSSLSFASCTLFPAVQSRLESSFLAWKQHRAEPSKVNTGIIKGADTASASIHFPPLSSNNARLKMGKVANRGCVQRSYGSSRSQSQLMSLSRLLSCNASSSSSPPDSSSSEYLKDSGLWETPVGDMSVVLSLQIQTKCSDLFAETPAVS
The following text describes a protein:
Function:
Transfers the sialyl residue from CMP-N-acetyl-beta-neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids. It's alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen. Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRTSAEYFRLALSKLQSCDLFDEFDKMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTAILTAFKPHDLRWLLDLLMGNKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNLVINLTQD
The following text describes a protein:
Function:
Translational repressor involved in the negative regulation of immune receptor accumulation via the inhibition of nucleotide-binding leucine-rich repeat (NLR) receptor mediated defense. Represses NLR protein accumulation (e.g. SNC1, RPS4, RPM1 and RPS2). Together with SMG7, helps to restrict effector-triggered immunity (ETI) cell death induction during pathogen infection in a salicylic acid- (SA) and reactive oxygen species- (ROS) independent manner. Required for pathogen-associated molecular pattern (PAMP)-induced suppression of necrotrophic fungal (e.g. F.moniliforme) pathogen-derived mycotoxin-triggered (e.g. fumonisin B1) cell death; (Microbial infection) Required for early steps of plantago asiatica mosaic virus (PlAMV, genus Potexvirus) infection. Facilitates pathogenic growth of avirulent hemi-biotrophic bacteria P.syringae pv. tomato (Pst) DC3000 (e.g. AvrRps4 and AvrRpm1) and of the compatible oomycete H.arabidopsidis Noco2.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, P-body.
Sequence:
MANSSAGSAADHRNKHLSVNPPHQIFKDIQGSDNAIPLSPQWLLSKPGENKTGMGTGDPNQYGNHSDVVRTTGNGEETLDNLKKKDVFRPSLLDAESGRRDRWRDEERDTLSSVRNDRWRNGDKDSGDNKKVDRWDNVAPKFGEQRRGPNDRWTDSGNKDAAPEQRRESKWNSRWGPDDKEAEIPRNKWDEPGKDGEIIREKGPSLPTSDGDHYRPWRPSQGRGRGEALHNQSTPNKQVTSFSHSRGRGENTAIFSAGRGRMSPGGSIFTSAPNQSHPPGSASDKGESGPGEPPHLRYSRMKLLDVYRMADTECYEKFPDGFIEVPSLTSEEPTDPLALCAPSSDEVNVLDAIEKGKIVSSGAPQTSKDGPTGRNPVEFSQPRRIRPAGSREDMTFGAEESKDESGETRNYPDDKFRPEASHEGYAPFRRGNEAPVRELKEPSMQGNAHVQSASPWRQSSGGERSNRNSHDWNDPSADSRLKSSDSVWSHPKDSINHLGGNNMMLPQSKGESRWQISEDPSLRRQPSLVFDREQEVRKLLPSSPEELSLYYKDPQGLIQGPFSGSDIIGWFEAGYFGIDLLVRLASAPNDSPFSLLGDVMPHLRAKSGPPPGFTGAKQNEFVDAAGTSAFPGVGKVHSGMGETDMLQNDMRYKHVAGTVAENRFIESLMSGGLTNSAQGVQGYGVNSSGGLSLPVTDGGADMYLLAKKLELERQRSIPSPYSYWPGRESANLMPGSENVSENAQQPTRSPSSDLLSILQGVTDRSSPAVSGPLPAWSQPIQKESDLHHAKTFQTQIPFGVQQQRLPEQNLPLSGLLGQPMENNPGGMLSPDMMLAAGLSQEHQSLNLLQQQQLLLQLNAQTPLSAQHQRLLVEKMLLLKHQHKQEEQQQLLRQQQQLYSQVFADQQRSQQRFGDPSYGQLQASLDALRLQPSKDMSQVNQQVQVPVSHEERGINLADLLPVTHATNQTVASFETPSLHLQNQLFGNVDPRMVLPDQIDDTHKKESKSEYERTVSADYVNSLYSEKPVLSPGYHATHNVEEPVSYPNNESSTATMTAPEIVESKLLEEQSKDMYAGKGEVSIELSGETPATEVKNNDVSVARKTSEKKSRKQRAKQAADLAKSTSRAPLQETKKPQPGSADDSEIKGKTKKSADTLIDNDTHLIKSSTATASNTSQMSSEVDSVRGEESSLQNTRTQPGRAWKPAPGFKPKSLLEIQMEEQRVAQAEALAPKISSTVNSVGSAAPWAGIVTNSDSNILRETHGESAITQTGVVKPESVPTLKAKKSHLHDLLADDVFAKSSDKEREVMEIISNNDAFMQVTTTNAESFDDDNFIDARETKKSRKKSARAKTSGAKIAAHVPAVDTSLQTNSVEKGKSSRILQQQEKEVLPAIPSGPSLGDFVLWKGESVNNPPPAAAWSSGPKKSTKPSSLRDIVKEQEKMTTSSHPPPSPVPTTQKAIPPQAHQGGASWSRSASSPSQAVSQSSSQSKSKGDDDLFWGPVEQSTQDTKQGDFPHLTSQNSWGTKNTPGKVNAGTSLNRQKSVSMGSADRVLSSPVVTQASHKGKKEAVTKLTEANGFRDWCKSECLRLLGSEDTSVLEFCLKLSRSEAETLLIENLGSRDPDHKFIDKFLNYKDLLPSEVVEIAFQSKGSGVGTRNNTGEDYYYNTTAANDGFSKVGGKKKAKKGKKVSLSASVLGFNVVSNRIMMGEIQTIED
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP.
Sequence:
MTDKLKFKTSLLNKVPPPPPKSNQPSPSTSTPASPNVNSTNNSPSVSPATTSPIPSPGMSPLLTPENNNNNTNIPHQTSLLNNSISNKSSVSFLNNSGGNTINKSSPLSQSSSNIKNGGPIRTSTTLAQFSGSSLPNTENSSPPPSSSLISSSSSPTAESLLYSEDSIASGGTVTVDPNTKNGNIYNGNGLRNNSADILPHNNHTYCVGDDGFYLFGGTLPDGSYTNDFYTFQFAIKAWTILTFGSAPSIRTRHTGVLYNNSMYIFGGYSPSGPKNDIYVFSFDTQTWSEVQTEGTKPSPRYGHTAVVESGHMIVFGGISCDQTTKQQTVNNDIFSLNLDTKQWSQVLSTCPPSPRTHHTATMHKGNMYVFGGQDQQSNQVEDIVHCYTWASNSWKSIQFEGSSMTPRSDHSAVLFQDSIFISGGSSKSQTSQNLEIYEYDLYQKKCFKISSSTIVQNRISHSSVVKGNSILFWGGCTDNSFDYFSFGKDEFEEDYQDDYESNRVQNIPKELWEASLMKKHPEILELREKTLAFTGSKSFAKTLATPSFSENRLALSHQFVLQLIMEYLERNTYHKVIAAIQKESGVLHQPTESGESRLVSLLRLVKPRLRNKNVFDTDLSLFSKEEGNDPEVAVVDHLYHDYRHFDEEEDINVWEEGEDNNRNIRKVETDNNKVQIKAATFNKLIHYLAPKEKAFDPNFLKVFLYTHSSFTTSEKLLKKLIQRYQVPNSNANEPKYKSEVVEPVRQRVVDVLKYWVDKCPWDFNAGPTSSVLVATLNNFIDGSLTRDGNSNIKKLRELKKKLQHEDVRPYSEPPPEPKVPKNIFSPQLTLAHIDELEIARQMTLVESKLFGAIPPPEFMVRVIGYGEFQYNMATSPNLMTFVNRATDVSRWIVHTVLNESRDKKNKMKMLDKFIKTTECLRQLNNFQTLHSVLQGLQHPLLLSRPDLFTPRHREIIADHEMLFSKIDNYKLYREALARSQPACVPWIDIIREDFAQIERDQPSNMNNLINFTKRQNLYEILSKIGHYQFPYNLQIVHQVATFVNKLPKYSEYDLNLLSESLQSQVNSPLAGVYQPSLIGTTGSSSSINLGSARELNNSNRDSNNITGSSSNNNSNSSNSLSPIVKL
The following text describes a protein:
Function:
Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export. Responsible for energy coupling to the transport system.
Sequence:
MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGSGKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTVKENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIHDPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKDGQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH
The following text describes a protein:
Function:
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Sequence:
MTENVNSSGDSAIKSEDKEEVTVIQEGQAKVGFHGPVFYNPVQEFNRDLTVTVLRQFSADHQKWAEEQKQLKTEEEPPKKKNKLAINEDGKIRILDALSASGLRALRFSKEVPNVGFIMANDFSDNAVASIQENVKLNGVEDIVEAHFGDAVMTMMEHRGIDKRFHAVDLDPYGTASTFLDSAVQCVADRGILMVTCTDMAVLCGNTPEACYNKYDAVTTRMKCCHEVGLRILLRAIDSAANRYTRYIEPLVSISVDFYVRVFVRVHTGAFQAKQSGTKVGTVLVCSGCHSMEPLVLLKRGEGNQQSKYSIPTVRHSISGPGNRCIHCLLPLHQIGPIYLAPIHSKPFVTSLLERLKSTPEAERLGTHGRLQGVLTMVNEELDDVLYYEHNQMANVVKVSVPKSQSVRSAILNAGFKVSGSHCNPRAIKTNAPMHLLWDIYRQVAKDTSVDREKRLAKESAGYHILGQPITNTVNFTLHPGAIEQAKKENLVRFQCNKGKNWGPRQKAKGSVNSTKAGFQLTEHKE
The following text describes a protein:
Function:
The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. OAF1 acts as the sensor for oleate and inhibits PIP2 activity under non-inducing conditions. Activity is repressed by glucose.
Miscellaneous:
MISCELLANEOUS: Present with 92 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif (residues 1034 to 1042) is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MVENSTQKAPHAGNDDNSSTKPYSEAFFLGFNNPTPGLEAEHSSTSPAPENSETHNRKRNRILFVCQACRKSKTKCDREKPECGRCVKHGLKCVYDVSKQPAPRIPSKDAIISRLEKDMFYWKDKAMKLLTEREVNESGKRSASPINTNNASGDSPDTKKQHKMEPIYEQSGNGDINNGTRNDIEINLYRSHPTMIMSKVMKREVKPLSENYIIIQDCFLKILVTSVFLDTSKNTMIPALTANANITRAQPSVANNLLKLKEMLIRQCQTEDEKNRVNEFTDRILQNTNSNRNLKIGMLLSMLYNSVGYQYLEDHCPQGGEYSDLLRNLINECEAILPSYEIIERYKNHFYEYVYPSLPFIELEIFEESLSQTIFPDPNNPSKVQIRMGSTHLRAKVENLSLLLVILKLSYMSIRFLDHSTADSSFYLSKEIIDKYPIPNDFILLSQRCLASENWCACANENIISCLLYIWSFFAFSPEEGDFFLEHPTDVISSLIMMLSTSIGLHRDPSDFPQLISPSTSDKRTLNHRRILWLSIVTVCSFEASLKGRHSVSPISLMALFLNIKDPDSLTVYMNRVRGDLSDINNHKLLRIHKFTFKRAQLALLLSDLDNLTMTYYGSFHLHSIEFIREKIEIFVEENFPIVPLKSVAQDKSDLDDMNVISEMNILSSENSSSFHNRIMNKLLMLRTSMAVFLHFETLITKDKSIFPFYKKYFMVSCMDALSLINYFNKFFNGEYRHAISSLTSFNVTKFIQLALSSTIFSLLGIILRIGLAIHMLSSEVQKLSGTTDPRIKELNTKVEKFSTLQRDLESALEGIYCSASEHLRFTYFPVFKMLALFDVIVQRMRKGELWHGIFTMIQMEQMHSRIIKTLSITLGVKLDKKDRLLEELMACNHVANFSVEDIDELNRNIKKEIQISSGLKPPVNTIDLTNGEPFGNAVPTFTKTWSSSLDNLEKLSSAAAVGQSLDYNSGLRQGPLAGGGSKEQTPIAGMNNLNNSINATPIVDNSSGSQLPNGFDRGQANNTPFPGYFGGLDLFDYDFLFGNDFA
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MPAPVALLIAGLVFLLATPLTQQHEYIPFSYVGSTGPNKWGSLNQQFSVCSTGKQQSPVNIVKDEVVYNPKLQPLIRYYSSANATLINRGFQIGLLYGHGVGVLDIDGKSYNLLQMHWHSPSEHTIDGVRHAAELHLVHAADDGSLAVVAILYKYGDPDPILFQLKGYINELAKEICAGDEEAHIPISLVRTKQIKRSTRKYYRYVGSLTTPPCTENVIWTILGKVREISKEQVHNLTALLEPGYKNNSRPVQPLNGRKIYLYNEKHKN
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MFKILQYPDPRLKTAAQRVEKFDDALQKMIDEMFETHYAATNCAALAATQLDMENPKHITVIDFSPNKDQPLCLVNAEIIERSGEHTEEEGCMSVGGGTFEKVTRAAKIKVRARDRYGKPVEFEADGFMAKCIQHELDHLNGIIFLDRLSTLKRGRIDKRLGKLRRQGKV
The following text describes a protein:
Function:
Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MDCIDKSIRRESLRKLGCLPDHGWNLFVQSSNRYSKLLEADSKLFKAQRIEDTVLSICEVTLENKASENALTLFQQLRFYLLNYLFLEDTSEYKSVLCSLDESVYPNLLPLTANICPCILKALLALVRQHRELSSDIVKFLNSIFLALTRILNTPHSSNNNPTHTKTTIFEKVFYASHLGFFFEEIADACISALPQDACLWAMEVCNTILVSDLPCKLIDLHNDSFLHHSNYYAGFGLSYYLYLSSMKAYINSSGCLWYEDATSFWDIVKHRPSSPEEKPFLTQFQSILNLSDKFLSKTGTLRLQEKLGTSCNLFFVLVLKLALLSSSYIGFVPYTYSDWINVLLGSISEDPELLPHLIELMASLACVFPTHFQFAMKRLRLIAIYAPRFDDGNVTYAQLASRKLAQLFNYSSRDTAITSIYQFANLLSPADTPDSYLAAPKERLSISDNMSSSSSQTATVNTISNYLNVIDSVREIALTVNDEKIYGLAISLLIQKFSRKFDSRVSTELVRTLADISTKANDRDFSILVQFYSIQNKMLVKNGDEALTIAICDSRCLIARGTESNSFKRSDLLKSLLEEIIHIGIVRDTPAPELKGYYFGMSKAVQALVECVAGTDWSSLPKEEMYPALFRDMWFTLVINRFRYSVDLGETLEVDLENIAKNSPLLVFEDFGSNFESNLELNTVLRTHIEHSVISQIKSELLVRVPNIDLKPLSTSEICFLSAVLLLESLRCKSNKLSALVEYLLDPSLRDSQLPQSIRAIALYNLTSFVESLSKERRVASSTIDEFQKLLCLCCNRVDCVRQLALECMNYIMETLPHLLGIKEILFSVLELSSLLWKARTEECTDQYVPQLLYKSNKLNLSVILSDIYSCREEVLFQFNRHARSWIQNSSKAIPYQVKNLLESYLADFVDFDDLEVVELGRSLAVELGTRIVSSDRDNFVLPAFGNWTPDTSSEFMAEYTIRQRYSHVDNSILNIEGDMSTDRIDLILNEKSKLFETHLAALKSLEDDILQGNTVSPQRLRNEVRKAAAHAVQEPIFQFSVLARKIVRIPFLDFSPSSFKLGITLWNWMMNQVPSFSSFLISNIIRNWKNEIVTEKRGYFSTAKSKSPLALPMTYSPTERASFLSYKNKVMSQMIPHLLLLQLIAGNFEGFWYGDRQTAKLIVHFMKFVLKKITSMEVNLNVLTRELHFKFVSFGLRIAENLLNSPLGSRFYNLCVDAGLCWFSGMPNWTYGADKLHVAAEISVMRSLRDKLDSFLLRYPLKVSTTLKQKLLIILLNNEMYMLYTWLTPVLHGRNVRMVEPIPDSDAASSPITLEMLQVAWNVSPNIVLYAPKRFQNAPLKQMALNFVIANPFTSVKHEVALEYLFEHYPSGEFPIDRKFILYWEPMYPVSGPVMFMPNVKWNPQLLQYTMRSMESYPVSVTFFYVPQIVQSLRYDSMGYAESFILETSGTSQLFAHQILWNMKANLYKDEAATVPDSIKPILDRVMDKMINSLSGEDKQFYEREFTFFNEVTSISGKLKPFIRKSKPEKKAKIDEEMKKIKLDVGVYLPSNPDGVIVGIDRKSGKPLQSHAKAPFMATFKIRKEKLVDADPEELAVNGTEEEAGDSAKKQTYEVWQSAIFKVGDDCRQDVLTLQLIAMFKNIFNSVGLDVYLFPYRVTATNPGCGVIDVLPNCISRDMLGREAVNGLYDYFRTKFGDEDSIAFQKARSNFVQSMAAYSVITYLLQFKDRHNGNIMIDDQGHILHIDFGFIFDIAPGGITFESAPFKLTTEMIAVMGGSNKSQPFQWFQELCVKAFLACRPYAHYICQAVEVMLDSGLPCFKGQLTITHCLERFALNLNERQASTFMLHLIEQSYANKRTLMYDQFQKATNGIPY
The following text describes a protein:
Function:
Metalloprotease that cleaves substrates preferentially between Phe-Phe residues. Plays a role in response to some stress conditions. Seems to regulate the expression of speB.
Subcellular Localization:
Cell outer membrane; Lipid-anchor. Note=Proper membrane localization can depend on BepA.
Sequence:
MKIRALLVAMSVATVLTGCQNMDSNGLLSSGAEAFQAYSLSDAQVKTLSDQACQEMDSKATIAPANSEYAKRLTTIANALGNNINGQPVNYKVYMAKDVNAFAMANGCIRVYSGLMDMMTDNEVEAVIGHEMGHVALGHVKKGMQVALGTNAVRVAAASAGGIVGSLSQSQLGNLGEKLVNSQFSQRQEAEADDYSYDLLRQRGISPAGLATSFEKLAKLEEGRQSSMFDDHPASAERAQHIRDRMSADGIK
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MKPAMDYRPVQLDDALENDLRQLVRLSIAEDLDIAVDWTTVAMIAPERRGACQIVPRCSGIAAGIALAPWIVDEFDADLEVEVLIDEGTPLVPGEPIVRLSGSARDLLTSERVLLNILSRLCGVATLTGRYVEAIGEHDARLYDTRKTTPGWRRLEKYAVRCGGGHNHRTGLYDGFLIKDNHLALGRSEHDPSSKLTAGEAATRAVAMRGASVNQLVAPPMVEIEVDTLEQFEQVATTGIDIVLLDNFSLDDLRRAVARRDELGVTLDLEASGNVTIDTIGNVAATGVDRISSGALTHQATWLDLGMDWLDGFAS
The following text describes a protein:
Function:
Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
Sequence:
MERNRLARQIIDTCLEMTRLGLNQGTAGNVSVRYQGGLLITPTGIPYEKLTESHIVFIDADGQHEQGKLPSSEWRFHMAAYQTRPDANAVVHNHAVHCTAVSILNRPIPAIHYMIAAAGGNSIPCAPYATFGTRELSDHVAVALKNRKATLLQHHGLIACEENLDKALWLAHEVEVLAQLYLSTLAIVDPVPVLDDEAIAIVLEKFKTYGLRIEE
The following text describes a protein:
Function:
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MAQGKGFGFGLGKIKELQEAFQKAQQVQEGAKVLQEELERMEIPGKSADGLVTVLMSGNQEPLSIEIDPSALEKGAEGLSASVTEAMKAAYAESTETMRSKMEELTSGLNLPGM
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MCEYVRWSVDYIEQNAKHVRVNQIKLKEKIIPLLEKIEAETFDESIHQAPNDIESRLRYILVVDALNFCFWPTEGFEYDDLTKGLSRLEHDHPEVFEPNQMKHVSSCLLSQYLVYNNRVISNIEERTRLMREVGEVLCNRFDQKVLNLLEESKYDATTLVSLIAKEFPGFRDSTIYKGRQVFFYKRAQIVVSDIQGMCGCIKGLEQLTGFADYRIPQVLLGWDVLDIEDQLKQKILDKKEIPSGSEEEIEIRCTVLSAIKMIQAIFLETKNSFIEGYRIDWFLWSYGEKNKEQLPPHHRTQTIFY
The following text describes a protein:
Function:
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Required to suppress amino acid starvation-induced autophagy. Enhances the STK11/LKB1-induced cell growth suppression activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MESLLLIAPITALEFVGDHLLSGEGPYLTVYSLEKDHLISHRKRQNVLQGYTIHGIKLNSSATVEGEPMIVAVFGSKGLIVLQLNISDDDVSLTEICMLRELHDWIWDVQWLGDCLKPAAYLGLALGHNSVALYDFLSGKVLKEVHCAEKCILYSACFYGHSWEELVLVSGTVFNQLVVWGVSDPTNKDGRTEPRQRISGHNGVIFSIFYKKKRGLLASASDDRSLRIWDVGDLVAKSFDVKCLLVLYGHQSRVWSVKLLHENIISIGEDSACIVWNYQGDIVSHFKGHKGRGIRAVAVQGREDLVATGGADSAIRLWQINGKSSRSNELLSLQFSSSHSPGAPKAIAMVDTTLLIVMTDLGSIYTYDFISKKWSFILTDENYKSYCQLDIYKTSNNVLCAIGNITGEIKIFSLSSPKIFKDLKCHQGKIHSLSWVAPLCPGSFTCGLFSSGPYGLMVCLEVTCVSGYVESVAEKGRFVLPACKQRWHTSVAFLPDEEFIVCGDRRGSLMLFPMNATNRGQDLFQGAIQSESGALHLKENVDDFVGEQRPNCPSTACSVLSVEGPVSLLFGIHGKLGVTSISCHSGFVYSTGRDGFYRQLKVERGQLTLLRKLKSCKGMEWIERLSFTADGNLLVMGFHATDFVVWSTRTNEKLHCVPCGGGHRSWSYRKEEHTEVFAYIKSCDIFAYLSHPVGKTQSILKEPVHGREITCVKYAGSLKTYEHLHVLLTSSEDTTVNILCFNAATNSLYQLSTISDHISSVKALALAQTKPCFQQDSSLSAVLFSAGGRAEIECYHIQINQGKDEESVLCQVIHLASHRLDEHWDRMKNKHRLVKMDPETRYMAITVVGEEVRDNPPSSLVFLAAACSDGSVRFFAVCTNSRKMLLVAESFYHQRCVLKIRPFVHRFVGGKRDLLCSAATDGRIAFWDVTDTIEEARNILQGEHEDFQPLNLEDPCFTVSAHQCGINSLHIQETKDGHYLVASGGDDNSIHICQLTVNNTTCETDNRTSIQLLKVFTVPSAHAAHVTGLRFLREDLLASVSVDQRLSLWHLRKDGGLHPRGTKFCHVADVSELDCWENVATGGHYGVLCGQGLEIMCIPSKVPELDQEG
The following text describes a protein:
Function:
Probable serine-threonine protein kinase involved in the control of defecation rhythms. Required to increase the length of defecation cycle period. Acts in a cell-functional rather than developmental aspect in the regulation of defecation rhythms. Prevents preferential activation of the p38 MAPK pathway in response to the levels of vitamin B12 in different food types during larval development, thereby regulating the expression of cytoprotective genes, modulating life span and stress tolerance.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPINYNRNAVELKLSSQLLQWLDQRLPLGDPMRIPSIDSYKYIQDLGKGRFGTVCKFSNGNTFETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRGSVKDLLVKETLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEYFGHIDEIPKVLLGYAKSEDGKVLPYTSEVLVPSSSNCVQKIVDLVFIKSPEHRPNTHKLRIQIKKILDDDSESEEETDISHPISNSNTDSSTAISHNHSNDRKVGRAGTCLPIESMEYAAVRKELKKRSKPKSNNIMQIFVASGYYLSRILYFLNILTRSICYLLLFLSLGITALGSFLLISYFVVRFVRYLIAINCNCDLMQPQYLIISGILIVLMFALLFSCCMVALGEYKFRMANQTLDGSKFYLPRPQKSAVLCGITVITGKEDAKDTAQNMEEEIHLTPSVRRNHDDYYYDESSGPANEEN
The following text describes a protein:
Function:
Involved in the ornithine fermentation pathway. Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine. It is strictly specific for AKP.
Sequence:
MAKKGDWVLIHKIVLSPEERAPQVPDDTKKVPLEMWIKGYLNEDAQIGDQVSITTRTKRVEEGKLLEVNPYYTHDFGKFVPELLKISEQVREITFGGEGNE
The following text describes a protein:
Function:
Catalyzes the conversion of trans-anhydromevalonate 5-phosphate (tAHMP) into isopentenyl phosphate. Involved in the archaeal mevalonate (MVA) pathway, which provides fundamental precursors for isoprenoid biosynthesis, such as isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Sequence:
MELREAIDNLLERKLIEVVEDPVSVEYEAASYLIKYDGKKALLFKRPVLADGRESIFKIFGGFATSRDVLAASMGLKSVNELRKKVRESLRDPGREPVESHPEWRRAKLSLKDLPILRHYTGEPGPYMTASIVIFRDEGKFSSSYHRMLPISENKLVLRAVEGRKLSRTIEKYSRSGKSLEVAVSIGNPVEVLIASAVPAEDRDKLSLASGISGEPLEISKCEDLDAWAPSKAELVICGRIEPGELAPEGPFYEILGKDIVRMQPVLTVDSIYVRESPIYQAILPAGMEHQILMGLPVEPLIEERVSEVAEVVDVAMTPAGAGWVEVAISIRKTHDDQPALAGIMAISAHKSLKRVIVVDDDVDVTNYIEVMRAVVQRAHIPEDYKMISGVRGSSLDHSNLREIYLDGEKRILRLPQGKMIIDATVKGPRDLTEIPRNPLVGSNR
The following text describes a protein:
Function:
RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure (By similarity).
Subcellular Localization:
Nucleus speckle.
Sequence:
MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEEDLFSSGFDLFGEPYKTNKGDALANRVQNTLGNYDEMKDLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQARLEDFFVYPAEQPQIGEVEESNPSAKEDSNPKSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRESQHLTPGFTLQKWNDPTTRASTKMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSIDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMNSSGSNNNLSISNEEPTFSPIPVMQTEMLSPLRDHENLKNLWVKIDLDLLSRVPGHNSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPTEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRNEGKFCATFKGISVNEGDTPKKASSATMTITNTAVATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVGNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL