lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. The beta-1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling cell division and cytokinesis. In addition, involved in vulva morphogenesis and in the directed migration of gonadal distal tip cells and hermaphrodite specific neurons. May be required for nunc6/netrin-mediated dorsal guidance of distal tip cells.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Localizes in punctate foci in the cytoplasm. Co-localizes with sqv-1.
Sequence:
MRVFQRSTCRMPVSRATVTILLGILFGFSITYYLTALKSLTNPIICGPEQQIGGFDYLDVISQRADADVFTRSQSLPGHRRGLILVAIMTAAKYVDTRAYNVWKTWAQHIPGRVLIFVAEGTESVHEDMPLIRLKGVDDTYPPQKKSFAMVKWLAENMADEYDWFLRADDDLYIRGEELALFLRSVDSSKAHIIGQAGLGNSAEYGLLALGSTDNYCMGGPGIVMSRDTLLKVSPHLESCLQHMLTSHEDVELGRCIRKHVGVACTWNYEMQKLFHNNQSAIKESYAKNMKELKDAITLHPIKDPAVMRKVHLRNREIKLREARAKRSLLSSELSTAKAQTLVRMTPNRTNDLTPWEYINNNKILFCADRVNCPRHTVDLSIRTEMADTITQLFDEFNTNARQRGRVLQFQSLQYGYMRVEPTKGVDYVLDMLLWFKKFRPPNRTTISVRRHAYVQQTFGKLRSLSEGVFRSNMRANSTLIEDPTLHMIMPLRGRAAIFARFAQHLKSICARGGDDLAVSLTIVLYSSEDEMENRETIEMLRASFIPVTVIEMGDVSFSRGVALMRGAETLPANALLFFTDVDMLFTCDALKRIKSNTILNAQIYFPIVFSEFSHESWSENDKLLADAFHYGRGRGYFRHFGYGLAAMYKADLMDVGGFDTKIEGWGKEDVDLFEKAIKNGRLRVIRVPEPGLVHIYHPIHCDENMPTAQKDMCHGSKAASLASIDTLVEQIAQYT
The following text describes a protein:
Function:
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSITIELLAGLEQLSKTKKSDHEMLVTHPVDFTEVVDYVATKLLEKHGNVFTGPQSNLAPGIIALINDQDITVLPKDTRIRAGDKVTFLSMVHGG
The following text describes a protein:
Function:
Inhibitor of serine proteases, strongly inhibits subtilisin A and weakly inhibits trypsin. Does not inhibit chymotrypsin, papain, pepsin, pronase E, protease type XIII and thermolysin. HPI-1 inhibits subtilisin A with an Ki of 0.21 nM. HPI-2a inhibits subtilisin A with an Ki of 0.08 nM. HPI-2b inhibits subtilisin A with an Ki of 0.1 nM.
Sequence:
MASQCPVKNSWPELVGTNGDIAAGIIQTENANVKAIVVKEGLPITQDLNFNRVRVFVDENRVVTQVPAIG
The following text describes a protein:
Function:
Inhibits host platelet aggregation induced by low doses of collagen.
Subcellular Localization:
Secreted.
Sequence:
MAKAHSSLVFCLLALALVRFAQAKCTNGYTFLGIKELSEKDKQKLLDFHNKFRELTAAGEAPAPKGEDGRERRQPPAANMLELTWHKKAEKQAYKWARTCEWKHNNATDKAGNSMGQNLGRKMSTEKTDVDDTFDKWSYDLVRGWFDEAKLYKYGSGFSMSTGHYTQVVWANTSQVGCGYSYYMQIDEYNQKWYTGYLVCNYSPAGNFNNREPYEISKEKCTDPKLESSKNYKHLCVLKKKKKN
The following text describes a protein:
Function:
Required for the processing of the 27S pre-rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAGIESKQRRAQKKAAKAAMKEKKNKESNESSTSVEALNEKEMINTIKSPIIETADTADQENESEGSDEVELSDLEGIELEEDADLIRKRKLAINNTVALENIYERIKYPDDISFVENQAVTTKEPIIIENVEDDLARELAFYKQGVSSVKAAFAKLREANVLISRPHDYFAEMLKSDDHMEKVRQELIKEATAKKLSQQAKKQRELKKFGKQVQLAKQEERQREKKETLEKINLLKRKHTGGDLTTEDDFDIALSSASADTFKKGSRSTKSRPQPNPKRQKKNEKYGFGGPKHRSKSNDLDSLAATEFGRKGLKNIKSKKRPGKARREKARK
The following text describes a protein:
Function:
Part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B.
Sequence:
MPPVRFGPRKILEYDGRYGVLICHECRYAIQKSALQSHLLRHKIYRADRQQLVAMINELDLLEPDDVLLPPPESPPIDGLPVIAGYRCTAPGCANLCASLKRMKGHWRESHGIADASLARPAKLQTFFRGTKIRYFEVTPTTEDEDDEENESENDEEEGDVDLEEQEDDNGGRQSTTVTTSPGPSAPSVNVDLETLSYFHHFMSATSLTLPCPQDMQSGAQYWKEKAVPQALQQRWLMCGLLALAACHLAAFPDNAAAGQQHRKRAAEFSLEFRTGWRELADTSGEGLREVATEIECLLRCAHWALAESPCDQRIMPEPGVPEHLQSIISTIQSTVPAAAPHEAETSAYATRILRWNTSEAGNSVLAEIRNRLHDLPARMADTFGRPENIQDVLVLLSALAAMGECCDTSFASEEVGPAWWGMATWWTRVPLRFKELVARHYPASLVVVAHWAALMVNRTERCGCWLVKGLAMTILLRIAERLPEDDDGNVQRLVALTIAA
The following text describes a protein:
Function:
Promotes matrix assembly.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRCPPATPPLRTRDPCSLETRRRVPGIGALDSGARARIRSILPQGRRTASETRPDPWFRVRLWAGNAIMPGIGKNVVCEKAATSVDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARIYSGSLLSSSYGWICDELMGGGGLHTMGTYIVDLLTHLTGQKAEKVHGLLKTFVRQNATIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAAQEELLVRDSLAVGAGLPEQGPQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWETVELLTEEPDANQNLSETLQRNNL
The following text describes a protein:
Function:
Might play a role in the development of cardiac outflow tract.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEVDKHSVWDSLKEKTRPLIQNLSIRKSKKSSVKVDISKRRKLGHRMSLSVPNMKEIGCTAQEENDFIETQVSACSVSNRHSSPMLFHSRQREYVKQSKETSTWVQEDSVHMEIIVTEYDDVDCSPSGPKKDTCEDNILDLLQKECLGDDPSDQKPEERSGSIDLNSSLASQLSAELSGLENYESLSTLPSLLSYLLTIHLKEGRNLVIRDRSGTSDPYVKFKLNKKTLYKSKVIYKNLNPVWDETFVLPIQSLDQKLHIKVYDRDLTTDDFMGSAFLELQDLELNKTTEKVFHLEDPNSLEEDMGIIMADVSLSIRRRDPKDTGRSSRRRLGASKTDLYRRNRLWFECRNSTFSSSLTTTSLQGVPVAESLRKNQLWNGTVSITLLEGRNLSEGLTLDSFVRFKLGDQKYRSKTLCKSANPQWREHFDFHYFSDKMGILDIEVWGKDNRKHEELVGMCKVDIAGLPLQLNNRLVLPLENNQGSIHMMVALTPCDGVSISDLCVCPLVDPAERMQINKRYNVKSSFQNLKDIGFLQVKVLKAEDLLAADFSGKSDPFCVLEVGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLDVTVFDEDGDKPPDFLGKVAIPLLSVKPGQQVAYSLKNKDLGSASKGVLHLEIDLIFNPVRASIRTFIPREKRFVEENPKFSKKILSRNIYRVKKITLAIWNTVQFIKSCFQWESKKKSLIAFLVFLLTIWHLELYMVPLFLLLLFAYNFTMITTGKVSTQDNLEGMDIGDDDEDDEKESERKSIRDRIQMIQDIVITVQNVLEELACFGERIKNTFNWSVPFLSLLACCILMIATVLLYFVPLRYIVLIWGINKFTKKLRNPYALDNNEFLDFLSRVPSDVQKVQYAELKPCSNQGALRKKRS
The following text describes a protein:
Function:
Acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.
Sequence:
MEGSYLSAQENQPIPERLIPRSNSTSNLFALSSTFSKLNVRNDADYNYSNPNKKRHIYSGEIDCRSVTAARKFPVRSCSMTAAQQRKRTALFTVRERNSYHEGFNNDQDYVSQYQKPQYTFGVYKELTPYQLQRSKMKRSFQFPNGEIYKPKLDGKCTHSLKKPELNSRDSSLFKFSEKKGRNLSKDFVGPHNGTSVIHIPPNDTGYGVNSLELNTSVPSTIKSSVSSTSPISAVNTLTSLPESQTDDDDGYENKTVTISYCFENTVNEKHGSHIEKLDLSTKEKTKPTTNSGLFDRKKKTILGTEKYRCIKSQSKLKLGSVLKKLWRTSGNSNTKHGKKDTKRRRIPIDDMVTHSDGNSEAENDIELMDANLDGIEFDDDETLMDTDSIFDDLLSKENDKYDLRRRQLEIRQKLHETSHNDDGKVSFRDTEKHNVNEGLIDKTIIEEFSKLGEYIIDTRNQPPPRSSKRPSLDDNESARYFYNISTDLRQSLSGPISLPMHVGNDMVNRLRNDWEYIRFEDRRNSLPDSSFDKVETPPKPIKKDVRFAKEVCLASTWSSNAYERANPEFIMNRHRLLWMMKVHPSMNSAMNEIKLELNSYKKNEMVVHENSKCFTHYLI
The following text describes a protein:
Function:
The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity.
Sequence:
MAAMSIQNVEAEKTVLGSLLIDGELIKECRLTEQYFSMPVHKSIFQLMRKMESERQPIDLVTFISRVDPKFLEGIGGMEYFIGLMDGVPTTSNFSYYEGLVRGAWKMYQAGVLGHKMGERLIAEKNEEIIGETITALCELEEKDSVCEFDLKDALVDLYEELHQDVKEITGIESGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLHAAKSGAAVGLFSLEMSSKQLLKRMASCVGEVSGGRLKNPKHRFAMEDWEKVSKAFAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDNKILIIVDYLQLITGDPKHKGNRFQEISEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVIMLMYREDYYDKETMQKEMTEIHVAKHRNGPVGSFKLRFLKEFGRFVEIG
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MFLRLSLKTIKKCQSNFITSFNSKQYKFFTTHYGYDFFNNDENDSGGGEYQTSFDYDVDIEVPILSNVTTSNTTIINRPFYNNNNNNNLQVSSLTAEKLPKKIKINKKPLVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNSNNVNLTKTTKSTNTSTTQSQPNDQGLFSPTKTKNKTSSVNEKEEIEILNNFAKSLQDQQQKVKTIFDKFENIENDNSDNVDSQNLLELDELLTSEQQKIVNLIVDGGKNVFFTGSAGTGKSFVLKHLVSKLRKKYPKSVYVTAATGIAAVNIGGTTLHSFAGIKLGVAPAQRLAVEILQSKKLLQKWLDCSVLIIDEISMIDAELFEKLDTIGQMVRGNNQPFGGIQLVLVGDFFQLPPVHGNYAFECKAWKKSIDISVELTTVMRQKETEFIDILNKIRVGDIKEDMINRLVSTCNKPLDISNGILPTRLYSTNASVDQENQSSLDKLLGEPFSFQAVDSGNKELIELLDRDCPAMKNLTLKVGAQVVLLRKIEKGDGLVNGSRGVVVDFVKARVSRKNNKFHKVNQYLPVVLFNDGQKVTIPPSEWCVWSEEKAYRNQIPLKLAWALTIHRAQGMTLDKVECELSRTFASGQGYVALSRVKSLAGLHLKSLNTPALKTSPKVVTFNKKIIRSINNSHI
The following text describes a protein:
Function:
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLRLGLCAAALLCVCQPGAVRADCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQTSLQVLQLGYNRLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSLNAITVLQAKCRNGSMPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIKLHQVTFTSATLVVIIPHPYSKMYVLVQYNNSYFSDVMTLKNKKEIVTLDKLRAHTEYTFCVTSLRNSRRFNHTCLTFTTRDLVPGDLAPSTSTTTHYIMTILGCLFGMVIVLGAVYYCLRKRRMQEEKQKSVNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVARMSSIPSMVGEKLPASKGLEAGLDTPKVATKGNYIEVRTGAAGDSLARPEEELPEIENGQGSAAEISTIAKEVDKVNQIINNCIDALKLDSASFLGGGGGGGGGGDSDLAFECQSLPAAPAASSAATPGALERPSFLSPPYKESSHHPLQRQLSADAAVSRKTCSVSSSGSIKSAKVFSLDVPDHPTPTGLAKSDSKYIEKGSPLNSPLDRLPLVPTGSSGSSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGYSSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQQKL
The following text describes a protein:
Function:
Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
Subcellular Localization:
Mitochondrion.
Sequence:
MAKYLESKDSEFNQEVLYRTGENYKGEQTYTPRLVICDLKGSLGTLRHESELYEPTEGSRQAHAWTGKMELFESDPIKKNQYLQSLDTPDGEFKLSYAGDLSKNVKVWSDFNSLYYHPTTVYELTTHTHDDENNRFLLPTRGREVYQELAMDETLMDVRIRQFMEESDNPQGFQIFANSFDGFSGVAAATLEYLAEDYPKKARIVYGIAQPKSTSLSKEQTLVQNINQALTLKCMSEESTLYIPMRAPSVLKYGHGVWQSNLRKHENMYEWSGYLAAAIETATSPFRLTNAFRLDMADLSGLLNPHAFNSTTALAFGLPLSLPQSRDTSLASIFKADEKMNRFESAWDLTLETPYDQIDRTSHCSFSVFRGIASILQHQYPSLNGLQPYSITQVTEELTNFTKRYGPMLAQSAIIQTPFIVGPTFPQFFGPMVTTTGLIRPTSPKDTDQIGQSEKMLTPEPVTQCASYARLHSGSALKPLFEFAVASLKVSSLNNWVYTDYTHGQFGLDRSDFESSRETLQELCDAYGESVDYDDSFSDDN
The following text describes a protein:
Function:
Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Sequence:
MLSPERLALPDYEYLAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFWRCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVIVPTSSSGQHRQRPALGGAGTLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHRGINQALGALPDKGDLMHDPAMDEELERLLAQVPGLVNSVTASPEASCLPSRTPPRVGSPWRPLHHSRKVDGESDGSTEETDESET
The following text describes a protein:
Function:
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation; The flexible region (FR) is required for ATG7-binding; The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity).
Sequence:
MNNPLLAIQSQYWAVRDYLSPVLRESKFKEHGRITPEEFVAAGDFLTFKFPVWQWEKGESSRARDFLPPDKQYLVTRNVPCLRRATAVDYTNADEDAEKLLSFLDDAEEAPGPDDDWVATHINRSPPHRPTDMDEIPDIPDSPTTAPTREMAGLNVSSGGKLEEDEIPDIDDIPDMDEEGLEDLEDDAAVRIVHPSEAEVNSTAGKNLLQVRTYDCIISYDKHYQTPRFWLFGYDEHKNPLTPAQVFQDVPADHAFKTMTMESFPHSGAQLASVHPCKHASVMKKFIDRMEAAQGPAPTAEPETISSTSGTSGSAGGKEEKEKKKKWGLGSMVRKVTGGSVPKVEKDKDEVVTGVPVDFYLVIFLKFIASIVPTIEVDSTTSTAL
The following text describes a protein:
Function:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
Sequence:
MEDRRLDFNYQSCYCEENIYLLGKRLSERLPIHQFHVLFISNSNGSVLLNNQRSKDNGIVVWDYHVILLHSLAHSSSIYDFDTRLSFPISAIEYFTHSFPNGIRPELIPLFRLIPLQSYLDYFSSDRTHMLSESGEYQSPPPSWPIIQSPLALSSNQISHFISMDPIHLSEISRIMSLDQIISFVQHDCVQ
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MKRMLVRDFIYDRLYHPVEGYFVKNIQLGALKKPIEFKQLLGYEDYTKKLAENYPENQWLTPSEVFRPYYGITLGNYINQQFRFTRKEKLRIVEIGAGYGAACEGVLYYMRNHQPQTFSNMEYHLVDISPEACAQAQIRLSQDFKQQIKKGNLRIFNQDFLNYKQHTQNNEMWFFVFLEVFDNLAHDKVIDGKQVYVENMQEFAETISDPLIKEVYAMYQQFKQQNKDQDENLEDRFLFNTLRKVISKYYGNQKSNSIFLPTGALQVLKHIKSNFQNPSLVIADFDLLKNNFTQESINAPIVSKKLAKPHERLDYESYLVERGVADIFFPTDFNFVQHMVKQILGMDSQIFKAYQFAEQFSQSSWTTTKSGYNPLKEDFGNTSFLVTDHS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MATNEERKEKLLDLLQKWVQVEGFDSGFIEPIKCERVEHGKVVFSTVVQQKQCNVLSTLHGGAIATYIDIISSLAIISLNLDKVSPSVSVEISVNYSSSAPVDRKIYFISNVYKTGRSLAFTDTTIRLDSEEGQIVAKGSHTKFLPIQKKSKL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MDQASTAGASDKPAAATSNDSWRRSTSGDVLPATAGGGGCFDCNVCLEFAVEPVVTLCGHLYCWPCIYEWLRRRGHADDRSVSTRQPCPVCKAALTLDSFVPLYGRGGVRPKKPRPCGPAIPRRPAVHREAVEQRSAQHADTESDPSTRPPRDDAPLDVLYPPPPPLGRGMNVMHSASGGTALAALTWFSRGEVPPPYYSSPYHLAAWENRSPRLRRQHMEVERSLHLAFGVHSRRFQVVHMIKSCDHA
The following text describes a protein:
Function:
DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAPGERKKSSRKKKDPDAPKRSLSAYMFFANENRDIVRAENPGISFGQVGKLLGEKWKALNSEDKLPYENKAEADKKRYEKEKAEYAKKNSA
The following text describes a protein:
Function:
Asnovolin J 5',6'-dehydrogenase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations. DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB. Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H. The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D. There are two branches to synthesize asnovolin A from chemesin D. In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A. In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate. Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction. The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization. The following step utilizes the ketoreductase nvfG to produce fumigatonoid B. The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C. Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAITDTINVAIVGASGVTGGSIVNGLLALTGLTVKITALTRPESLNKPANIQLKERGVQVVAANLRGPLEKLVDLLSSIDVVISAIYWGSLDDEIPLANAAKAAGVKRFVQSAYNIPAAARGVTHLRDKKEVILSHIQQLRLPYTYIDVGWWYHVVLPRVASGRTEHALPFGMPDLPIALDGNIPSGLTHIRDIGRYIARIILDPRTVNKKVFVYNELYTQNQLCDLVERLTGEMPQRRYISEKCVQSWLQEALDELERNPSSDIALGVVSLREVFLASNVHGTNTPEYAKYLGYLDGKELYPDFTFLTYEDYVEEVLDGMHSQTVA
The following text describes a protein:
Function:
Required for efficient biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPKAAKPKRRKKSQSRTEVTSISDSESDTATKSQSSKPKAQPASTKSVPQTIPTPTIKTPSKPNPVKDSALAEKFTAHYLQRATIEFSEDLDKIREADDFNENALQILVHALKQGTEVWVVMGKKGGRAEWDDDDASGPGGDGMGKKTGRSIFMKNFSDFDNKGSGNRAIIVMKSAKNRHFKELEATA
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Sequence:
MFLRRALPRNLLLIQRRRISNVNVPFEDDLTGFEDDSLADFQHYPGLQQSTPVDQNNTPSTKTDKTIAQAPLQETTIIPQLSKISQLRNPVIFVSKLTNPYMNLAIEDYIYNAMPKPEGAKDNSFDRLMFYINTPCVVIGKNQNPWQEVNLPVLNSLGVPMLRRRSGGGTVVHDLGNVNYSYMTTKANFDRHKFASYIVEAVNQASPRFKIETNERGDIVSEKLLGLNYKISGSAYKLSKGKSYHHGTMLLNSKLDVLGKLLHRDEKKLGIVDSKMSIPSVKSKVINLEMKSDKFIDVVSQKFKSLYNVVPEEDTEMDEFNEMFGLTDFAKSQEVTLFVIDEATTIPEEIHITADELKQWSWRFGHTPKFTHSFKNQKHGLEILFNVEKGCLKSFKLTFDDSNSDTKEIEKSFQYLESHIKNNDLEYTGSNVAGFVLHDEISDWIGESIDGTI
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSKAPDDQLQATEQEESVHPSQQAGQQHVNTPDQISKTELTEGSKNEQPVQVEQQNSNLQQAHSEIQLQQAETNSFQLAEKETGYFGQQSFAGAKVDVAQPSVVQQNVKQTVGQQASSGAQDTRKGPSIPFNLLIPILQAHLDRDKDMQLQAVWAKLRRNEVHKDDFLRVIRNIVGDQMLKQAAHKVFVQMQAQAQRNSQANPSQQSLFSQVSSQQMPSSGSTQTQNSVHYLAHDNTNQNPDAKGTNAVPNQPPRMNTAVPLQAKNKQHQPTQLQQASQQIYGASNPGAQAYPRSITGSLRSPSPVPETQPSMHAPGMAPAKIVPPPTHPMMQHNAVAWQMHQNKELKTNAPPPNAIVKQNSESVGKARMAGTGNSSAKGKQGTPNSTPNASGGAKSKKSGGQKKSLEAAGSTQPSSKKQKTSGAFQEQSIDQLNDVTAVSGVNIREEEEQLLSAPKEESLASQEARRIAQEEEENLFLRKGPLLKKLAEIARKCDLKNISGDVEHCLSMCVEERLRRLISTLIRVSKQRIDTEKTGHRLVITSDVGRQILQMNQKAKEEWDKKQAEEADKNKKQTEADGSGATDLEKEKEESRPKNVKPNKEEDDKMRTNAANVAARQAVGGSDMLSKWQLMAEQARQKREGLDVSAASQPGRGPGSRPFLKFGNGPGEHQEGSKRSHSVAFGTGGMKRPGRTPFAGPQRLISVKDVICALEREPQMTKSRLIYRLHERFPVDSTVD
The following text describes a protein:
Function:
Has a role in germline cell development and proliferation which affects the frequency of apoptosis. Required for mitochondrial DNA replication and transcription and fertility.
Subcellular Localization:
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MLRSLSTISKSTVRCMSLTSKMAAEQPSKQEVDDLFAEKPQHHNPEQRRHAYSVNKVELVGGVALDPLYKTGRNGKPYLIFNIITNSYFKQQDGTTLDQTERHAVSVFGKQAEILSKTIKKGSRLMVQGRLHYSGGQKDEQGNRTQRNTYIIAQTVQPLARAARENPDQH
The following text describes a protein:
Function:
Involved in oxidative stress. Transcription factor that acts upon trr1 and ctt1.
Subcellular Localization:
Nucleus.
Sequence:
MPSSNGSSDFVRKLFNMLEEPEYRHILRWSDSGDSFIVLDTNEFTKTILPRHFKHSNFASFVRQLNKYDFHKVRHEEGAPSIYGEGAWEFRHDDFQLHHKDLLDNIKRKAPSKRNLANENTAPVIENLKQQVDSILDFQKLLDRNLSGLATSYQTILLKMFELKRGIESRDLLMSSIISYLCDLEGSTQRQANPGAMFVPSHPLQELLNAYQALAKGQVATTSPQQIPNQIQQASAATTASSKMTVDTNLGTAQPSLYNTPSSDYELANQEKPADSMASAASLNTPLSSNDHSLNPHAHGSYPMYEKFQPIQHPNPGSFTTHLDSNASMAKSFSQISNDSLAKASSVATSMSQMGAAVPTTGLWKRQPRILLVEDDELSRRMTIKFLTSFDCQVDVAVDGIGAVNKANAGGFDLILMDFILPNLDGLSVTCLIRQYDHNTPILAITSNISMNDAVTYFNHGVTDLLVKPFTKLTLLQLLKKQLLNLLQADNSINMSDVPSTKEAKDDKAPVTFYLENDAPMYPQQMLQDPIQADLQHPH
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDRDRQPEDTTAPTGEPVVSKPYIMPDDPEPGSVELLQKEAAEARDRMLRTLAEMENLRKRTTKEVADARLYGITGFARDVLDIADNLQRALDAVPAEARAAADPGLTSLIEGVELTERSLLNALEKHGVKKFDPQGQKFDPNFQQAMFEVPDASVPAGTVVQVMQAGYTIGERVLRPALVGVAKGGAKAASAANSNEVN
The following text describes a protein:
Function:
Increases viral DNA accumulation. Enhances infectivity and symptom expression (By similarity).
Sequence:
MDSRTGEPITVPQAENGVYIWEITNPLYFKIISVEDPLYTNTRIYHLQIRFNHNLRRALDLHKAFLNFQVWTTSTTASGRTYLNRFKYLVMLYLEQLGVICINNVIRAVRFATDRSYITHVLENHSIKYKFY
The following text describes a protein:
Function:
Mitochondrial fission factor that acts directly on lipid membranes to drive mitochondrial fission required for mitophagy. Directly binds to lipid membranes and brings about lipid membrane fragility to facilitate membrane fission and engulfment of mitochondria by the phagophore.
Subcellular Localization:
Mitochondrion intermembrane space. Vacuole.
Sequence:
MTLVGKLVHISIDLVLVSTCLAGIKRNTGLTPKLETLDNQTMRNYMKRYLNLGESVYDYSVATCGSSTYFARK