lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine, leading to relocation to the cytosol.
Domain:
The N- and C-terminal halves of this hexokinase contain a hexokinase domain. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single D-glucose and D-glucose 6-phosphate molecule.
Sequence:
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKSPVGFTFSFPCQQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAAVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTSLDAGILITWTKGFKATDCVGNDVATLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Sequence:
KAYQCKTCNRVFVRKKFWLKHKKSHRNSENNSFFYNNQTSVEKLFSCELCKHVFTSKGNLKRHLTVVHQGVRSYSCSYCHKLFGQKVSLQWHCLSVHKSDEDLLMCHQCGRQFSILRYLMRHVQTAHTQTSHKQYKCLLCVKSFVTKSELQKHQIVHTKFKCGKCEGVFTGKRAYSFH
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MSAHTRQMENPTGVVHRFMQDHQRVCVWLVHDPQIRLEGNLLGYDEFMNVVLGDTTETNLRNSKSYRLGKILLRSDNVGVIYPIGV
The following text describes a protein:
Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MSETWEALRKKARSTENSIDVKLVSLNKLTASSHGGFDIDEKTVSSRQTSFKTVTTEIEGLIEQLTNINDDMNDVAGAQSSASWANNPAIQHTLRRHREILRDYGSEYRRARDNVDQVLQRELLLSSSNENRNNPILNNRARGYDMYLKENDHINACDRLLDEQLEMAMSTKENMARQGINLRGISTRLHHISKKYPAINNLMQKIKTKKQKNTLILAAVISSCLIFTIFWIIN
The following text describes a protein:
Function:
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.
Subcellular Localization:
Cytoplasm.
Sequence:
MLGKIKHLDVPNGRMVLAVSDGELNNTVHDGRGSNHSLNSLPSVQIGGLASEKSVASWAVSFERLLQDPLGVEYFTEFLKKEYSEENIYFWKACEKFHAISNDDSAKLLEESHRIYNKYLSSSSLCPVNVDQQALITEDMLKTPSPDIFNAQQLQIFNLMKFDSYARFVKSPLYQECMLAEVEGRPLPNLNLSQSDPVASCHALASGAVKKKKLKAGKSLPVGVEGIDIETVTDKSHRRSFKKKDRIGHSKEALDSNGLSSRRESGVSLNSNTSLELGLNSSLTSKSENEGGSTGSADAEADTKSLKYCCVYLPDGTSSLTAVKPGLTIRDMLAGVCEKRGYCLSDVKVFLVGNEQKALALDQDCLVLTEQEARLENWISFELQMKPMDKSVRIVSKPTKTIGEALHSILKKYGLENQHIVLTKAGQCHALDQKSSVNEVAGQKLDLELVQFSDPTKAVGTTVEHHTKKHCTKEHKEDKGIPVTEPYHRAQHEPHHVNQVSSENGHSEAPHGKHKPHRHKYDIEGLVELLNKVQSTRADDQRGLLCKEDLVLPEFLKLPTDKDCCHCSMASADESPVITANAPHCLDLSQASQSGCEHNSSTNSISSRFKKDCLAESQANTATGVASL
The following text describes a protein:
Function:
Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MADRPSLPALIIAIAVLAGSYCRVASSASPAVEDELRGGGGAGGPTTMRRRAASVMVPITILKSAVSDGAVCMDGTPPAYHLDPGSGAGSRSWIVNLEGGAWCNSAKTCRLTRSSGRGSSDHMDKEIPFTGIMSSSRAVNPDFYNWNRVKVRYCDGGSFAGEAFDKDTGIYFRGQRIWNAVIRHLLSIGMANADQVTFPFSVHIRRPTVMLTCSLHSDRWVLQVLLAGCSSGGLAVILHCDQLRAFFPSGSTVVKCISDGGLYLDAVDVSGGRSLRSYFGDIVAMQGIAQNLPPACTARLDATSIVLSLAPDRADPSGAWRACKSNRTACSASQMSFLQDFRDQMVASVKGFSGSRSNGVFLSSCFAHCQSEQLGTWNTKPGGSPTIQNKGISKSVGDWYFDRAEVKAVDCRYPCDNTCHHII
The following text describes a protein:
Function:
Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. First, PqsC acquires an octanoyl group from octanoyl-CoA and forms an octanoyl-PqsC intermediate. Then, together with PqsB, it catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and resulting in closure of the quinoline ring.
Subcellular Localization:
Cytoplasm.
Sequence:
MHKVKLAAITCELPARSYENDDPVFAAVPDLSESWWQFWGVNRRGYFDPRNGENEFSLVVRAAERLLRSSDTAPDSVDMLICSASSPIMTDAGDVLPDLRGRLYPRMANVLSKQLGLSRALPLDSQMECASFLLNLRLAASMIRQGKAEKVLVVCSEYISNLLDFTSRTSTLFADGCAVALLTRGDDDSCDLLASAEHSDATFYEVATGRWRLPENPTGEAKPRLYFSLFSDGQNKMASFVPTNVPIAMRRALEKAGLGSDDIDYFVFHQPAPFLVKAWAEGIGARPEQYQLTMGDTGVMISVSIPYTLMTGLREGKIRPGDRIVMAGAATGWGFAAQVWQLGEVLVC
The following text describes a protein:
Function:
Transcriptional coactivator that together with FHL1 regulates the expression of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1.
Subcellular Localization:
Nucleus.
Sequence:
MGYKNSDNTNNKFSRKSMSPSLTGGKGRKTVGKKVKKTIPRKTVNWSSYDVNSDSNEDSDEESENENDSDNDDEDDDETEHHHLDGLYSLMGKRPHDSSSNGDDDDDDDDDNDNKNIFSSTSSDGDSDEAMFSSSDDDSDVDFVKLQAQQKAHALKIAKARKGLKSKPKNESNDNAIASSSESESNSESDNEDDDDDVVSLKKLKPRKKSFLKYGRRRSDAVLPDINFKFEFDTGENDELEAGNQETHIKEPEEEDIGEEVDYSPENPVDSNNVPSLEFEFDHHLIEVPKINEEELNSDEDYEIDDNELLATLQAENDAEEFLPPITKGNSQPQRNDSLISSTIEEEENDNDNEEASKGGDGDDDDDDDDDENDPFLKEEEKYLVNEFETNGFDENEEDEDEDDLHTFDSDFSTTNRIVNSFKGIGEDRSKPIVKYESSVSGGSDYDEDDYIDLINFDVPLFDDKNGHLDGGKKNSHHKGNTDKLKKDKVKQRANSNHNSDEDDDSYLWNYFFSSDNDSSSEETDDKNNSKTVNKSRKNKKNKKALTNNAITGADELFEQIENDNTFKSKSKSNHHGNSLYKAYSDSPMTIQDLEAEIRAGADDDDDDDDDYDSSESTDVDESLPKSSSNNSLVGSSKKATEVLSSKTADYRPPKLGSWVTVDCKPFGVIDGLSTRTLQLNKSQEPRSAAQSGTSHSTSIVNSSNGSGLGLPTTSIASSLAANPRKSIVVGPTNVPSSMISSDDSALGLDELLNVSELDNDDENDVKIWRDFNNNQNKKKIPLGAFRNKSVLYNNHIYQDDQHHHLHRRNSNADKKFNGSGHIKKQQPIRRQSQSKIERRRASIVEAVSQGYRPTKSGLFSETALADVEELLGDDRDLMELIQGL
The following text describes a protein:
Function:
Involved in nucleotide excision repair. Binds specifically to damaged DNA. Required for the incision step.
Miscellaneous:
MISCELLANEOUS: Present with 1030 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTPEQKAKLEANRKLAIERLRKRGILSSDQLNRIESRNEPLKTRPLAVTSGSNRDDNAAAAVHVPNHNGQPSALANTNTNTTSLYGSGVVDGSKRDASVLDKRPTDRIRPSIRKQDYIEYDFATMQNLNGGYINPKDKLPNSDFTDDQEFESEFGSKKQKTLQDWKKEQLERKMLYENAPPPEHISKAPKCIECHINIEMDPVLHDVFKLQVCKQCSKEHPEKYALLTKTECKEDYFLTDPELNDEDLFHRLEKPNPHSGTFARMQLFVRCEVEAFAFKKWGGEEGLDEEWQRREEGKAHRREKKYEKKIKEMRLKTRAQEYTNRLREKKHGKAHIHHFSDPVDGGIDEDGYQIQRRRCTDCGLETEEIDI
The following text describes a protein:
Function:
Required for proper chromosome segregation via regulation of CENP-A localization to the centromere.
Subcellular Localization:
Nucleus. Chromosome, centromere.
Sequence:
MMEKSLNTVTSLPLRVIYCIDRASAIRCLAKSQHAVPIQVLKEVEPKKVICQVDIQHVIQTVCRCSPELSCKSQGDFSVYFLDHTEPDELFVGLGYWSSLLLSPTLNAGTSNSDTVWVNGFIVEFGIQRSIEIKLRFQSLQNSFEVGTPETHTSSKFLSSTLPPSLIFDPSSSEKSDSISGSLFDTNYTCPVNINGLSKQKSVRELKSPSRPSALAETNVEELELDSLFHASNDISCSATSFSEPYILDHQAALDHPATDPVCSASSTTVNSAVSTKKRRRESSTISPESAYVAAQLQNPSEREQVHEFIKEQVRIARGRIEKKFTNVRGKNRIEEQLTLSLQEGKIPPYCQNCGTIKTANWRNATYMNITLMLCNACGIYWTSRRSMRPRNLWSTYKAFETEKPLENDAFAQLELAVYKLSQQRKLSISIFRELENAGRHSPLNRLTSLDSTHSAPDPNHISKPSVVNQQKSRGGPRTAKLKNDLRRIQSSPIVAPTPDTSFREPLSEIGSNDSWLVLPNSLSANIQNDVLRKTDFMCTDKENVAFPLKTTTKPMPKVNKEETEPTLPVCDSEKENDDLECYFRTPPKPTTLQKQQQSPSPWRSELFLSDPDQNVLTPRHKPKFDLSKALSSVAKSNNIENSPQLPERYDFSLELGLNSQLDNEERRDIPLMTDLVMPSSPPMVPADRHLSVENTC
The following text describes a protein:
Function:
Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA. Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (By similarity). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity).
Subcellular Localization:
Nucleus; [Isoform 1]: Nucleus. Nucleus speckle; [Isoform 2]: Nucleus. Nucleus speckle; [Isoform 3]: Nucleus. Nucleus, nucleoplasm; [Isoform 4]: Nucleus, nucleoplasm; [Isoform 5]: Nucleus, nucleoplasm.
Domain:
The coiled coil is formed by helices from two subunits in the MSL1 homodimer.
Sequence:
MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDESGAAEAHFLPRHRKLKEPGPPLASSQGGSPSPSPAGCGGGKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPVAAGAGCSPRPKYQAVLPIQTGSIVVAAAKEPTPWAGDKGGAAPPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSIRKSPLGGGGGSGASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKRDNEKERHKLLQGYEPEEREEAELSEKIKLERQPELCETSQALPSKPFSCGRSGKGHKRKTPFGNTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSISETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEMEDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDILENLDDSVFSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLLITPFLPVVAFGRPLPKLAPQNFELPWLDERSRCRLEIQKKHTPHRTCRK
The following text describes a protein:
Function:
Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSSTSSPTYTISKTLNTNYPLIDNDPHFRRVIGYARPSDYVHGTVAGAAGPGLLYLMEKMAPSGVGKGGFPKAMRLATAVGFFGGFLYFYQRSILRFYGMSENAREVQMDMREMVDKVKAGQPLYGVSTLPVDVQGMAARQSRYSALFFAVLPWFNFVNHNQHGVDTAKYYQQAERELEAERLGKGSSS
The following text describes a protein:
Function:
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MALDLRTIFQCEPSENNLGSENSAFQQSQGPAVQREEGISEFSRMVLNSFQDSNNSYARQELQRLYRIFHSWLQPEKHSKDEIISLLVLEQFMIGGHCNDKAGVKEKWKSSGKNLERFIEDLTDDSINPPALVHVHMQGQEALFSEDMPLRDVIVHLTKQVNAQTTREANMGTPSQTSQDTSLETGQGYEDEQDAWNSSLKTTQVNENITNQGNQIVSLIIIQEENGPRPEEGGVSSDNPYNSKRAELVTARSQEGSINGIIFQGVPMVMGAGCISQPEQSSPESALTHQSNEGNSTCEVHQKGSHGVRKSYKCEECPKVFKYLCHLLAHQRRHRNERPFVCPECQKGFFQISDLRVHQIIHTGKKPFTCSICKKSFSHKTNLRSHERIHTGEKPYTCPFCKTSYRQSSTYHRHMRTHEKITLPSVPSTPEAS
The following text describes a protein:
Function:
Part of the ABC transporter FtsEX involved in cellular division.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAVKPGNQKISKTTKSTKSKPRDVKRAKTDSFLAIHFKQAKASFAALWRRPLGNILTLAVISMALALPASLYLLSKNIASVAERVAEPSQLSVYLHIDTPEPRIIVLKDDLERRDEIAKVKYISPQQGLDDLSQYAGFEQAISLLDNATLPAVLVVTPKVDSREQIQTLAKALQAEEGVTDVRMDEDWFARLDAIRHLATIVVISLSSLMLMSVFLIVGNTLRFNVQANKEEIQTMKLIGATDAYILRPYLYSGMWFGLLGAVAAWLLTALMTILLNGAVEALAQLYDSRFRLIGLGWDESLLLLMLGVFLGCVAAKVSAKRHLKEIEPV
The following text describes a protein:
Function:
Required for translation of the mitochondrial gene for cytochrome c oxidase subunit II (COX2).
Miscellaneous:
MISCELLANEOUS: Present with 538 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLQRRFISSSGIKRLLHRESNKVMHTVFFKVRYYSTELIKKKHKEDIEDWVKAQLKDSSTISGVYESRNKLDWMDSITKSPSSLDILKNQYNIVKDKDFGILWKQKFESADPDILMTIISLSTNQKVLFSIQQLLILINSLHFLKRDYDIGQIYTTYEQFTPLLASHTDKGTYGQFIEIMLVVQHNLHHFDVCETLFAEYIKYCKVKPQMISLGLNSFIRSNNTQLAVEFYTQAITNPDTFPITEKQLFEFLRCMERYLDMSSMKHIFYLWLKVKCGDEQSSSTNLPSFKTLAIIHRMLLRFSNTDELNDFLTNPVVLSTGYTSSVQFELIEFCHSLYCIKGDRTKSIDDSILMERVDKFITRLNNNISTRKELYMSVVQAYVSTNNFENLKVILEKIQRDNDISIDGSFHLCISRYFVNTNQFEGLFKYYRSVVKTTDGKTRLRPAFIQQLWSCAVNVYPMLAKEITNDLLVTLKRSQYSKCLTWVYTFLQENAHIHTRKINGGEDSSLSGFNAVDFERFEEFKKKVSHNDVYGAELVISNSLKEGIAPQFSFLYSVLALCLRNSLTGLARVVDVILRTRFRYIPLKVDILWLKWEIISNYRSFEKLSAEHLKELEFKLKEFERVHQKELSVQNYLQLTQICFHTRDFKYACYLISQARKNLDTSNNKQWMMYYMTSLKLASRMHESERFSRILKDWNCNHRASLITPGCIRQIKGFMKYFEKRPAYISTAASIDNKEIKDRIDELVLRYVDYKYQGLENMRKLTLFLKEWFDEEISLLKLEQNERKMKLFEENKKEEE
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Modulates Mettl3-mediated N6-methyladenosine (m6A) methylation of mRNA 5'-UTRs and 3'-UTRs independent of its methyltransferase activity; influences mRNA stability and protein levels, in particular of Hsp70 chaperone proteins and other stress response proteins. Also regulates stability of transcripts encoding proteins involved in signaling processes and proteins involved in neurogenesis and axon guidance pathways.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Chromosome. Note=Chromatin association is not dependent on RNA.
Sequence:
MDTTEKALKEVTPAMLSLNNCPGTTPGTPMSKNQLKKQRKLAEFAELRKLRREREREKKKQKRREAKELGLPVRTGPSRKELKKRQLADGGKSGLSVAIDLDYDDLMQERDIVKCVKQCLRIYTINRRSPQPGNLHFTGIRRNGHIHESFKKNEGWENWHVQYYFDRGHTDIFEHSQLVYLTCESDRVLDKLQPGCTYVIGGLVDHNHFKGLCHSRATSAGLTTARLPLSEHVDMKTRAVLSTYHVFELLTKVAAGQDWTTAILETIPMRKGAKAKITDKKEPNHCLEQQDEKQKQEAESDKPTLTAVESEIESHSLDS
The following text describes a protein:
Function:
Diterpene cyclases that can form multiple diterpene products.
Sequence:
MDLPPALLSFYCPIASEVSPEHEAVAQEMYAWIHAMSLTSDNRQAKMLAQAGAGFNSYFTPRARGELARALSKYNVCAWIANGMVQEIRDPGTFGAMAARWARIMEEPATCPADGIPMDFALADAFSHIRRTLSPVKWQHFSAAQSHWMHGLAWENCLHQVKGLTVHDYLSFRYVMSGCFAAAAFAYAVPERHPSAEEWAHPKVRAAADAAMMVDALDNDRYSYLKESLTEADKKTIFAALRHENPALGREEVIVRGVQLRDRILTLYLTLRGELLCDASEGLRSYLTGLDLIIAGNLVFCADMGLRYGLPEGSVRTDAEPLDRTVAPPGIGAIDHWWAQAGA
The following text describes a protein:
Function:
Mediates cholesterol and taurocholate efflux. Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=Predominantly expressed on the sinusoidal plasma membrane in hepatocytes.
Sequence:
MIKREISVRQQTCALLQKNLLKKWRLKRESLMEWVSSLLLLLFLYWYPHGHGATDLSSVPTKDLGRVDSFRQSGFMIGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIKELTESHAEIIRVIFSDTFSYHLKFQFDQRIPTSRELRDHNAHCDGLYEDVNCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMKIHPFVRQEGILTDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFVFIMALSLALVIKSVQFFILTSFMVVFSLFLLYGLSMITLAFLMSALVRKSVLTGLSVFLLTIFWGSLGFTSLYRYLPAPVEWTLSLFSPFAFTLGMAQLLRVDYDLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHVILEDGIDPVPSSGDSFEPVSPEFHGKESIRIRNISKEYKGKPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQKRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAEGEGKLLYTLPLETTYRFPELCQSLDSCPGLGIENYGVSMTTLNEVFLKLEGKASIDEPEVDIVGEGQTERSGDTERLMEMEQTLSSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGICPFLFENISTKIRQSSYTWELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFIHSVERQNIALEVDASGTRDGTDDPSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNGLLGMVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILTSACPPYIAMSSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYLFRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVILLAFDVDGTQYYIIFLIPPSTLVGCLILSLHLFIGQIFEEGQVIEPFLVFLIPFLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPEDEDEDVQMERMRTANALVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGDTPGFLGYCPQENALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTLEQVEPLNTEILRLFPQASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELDGLELEELDSSIKWKLLPQEEA
The following text describes a protein:
Function:
Probably involved in translation.
Sequence:
MAAYQQIFSDVSTGRCSGTVVKRLSRFWETRYLNKEGELIGVDMLLLDEKFTGRRRRNRRLEHTTQIQAAVSLGFVDAAVADIAGATTASSSDGKDEQMAKTVVAVFVTLARSMQEFKWETLVLTDDGKKYAAEGSPEIHFVSAIPEEGSISKDDLELDPSVSKIGSTQAAKKRGWTGYSDVEKGHNNAPKRKIFATDLTRENLHPVSASLSFCPSDQQSFMSELDSQVPTAFDLFADANVEDSCAGTKEYIHIRVQQRNGRKSLTTVQGLKKEYIYRNIHKDLKKEVCCNGTLVHDSELGQVHVFYSKILKDLKKEFCCNSTLVANTIIAYK
The following text describes a protein:
Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MASAAKTLRDFFQPAAKRLKVVSVSSSDPPRTLNLCTDSIGDSSSEQRSRIQFNKHRAKSKRNLNHCLQLVSNSKSYVKLEELLVEETWVEALPGELQKPYAKTLCKFIEKEISCESEPIYPPQHLIFNALNSTPFDRIKAVIIGQDPYHGPGQAMGLSFSVPEDVKVPSSLVNIFKELKQDLGCSIPSHGNLQKWALQGVLLLNTVLTVRNHQANSHAKKGWEQFTDSVIRLISQRKEGVVFLLWGNSAQEKSKLIDETRHYILKAAHPSGLSANRGFFGCRERGKISCMSHSYGKLNFRNFDAIQWKLAFMRSELSSKNKLILTCKEDYE
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity).
Sequence:
MAGPVSLRELLMGASAWTSSESPEGSPTEGGGSAAGGPEPPWREDEICVVGIFGKTALRLNSEKFSLVNTVCDRQVFPLFRHQDPGDSGAGIRTEAGAVGEAGGAGDPGAGAGAGAGAGAGDPVRGGVTAAEGNRTEPGSQDYSLLQAYYNQESKVLYLLLTSICDNSQLLRACRALQSGEAGGGLSLPHAEAHEFWKHQEKVQCLSLLYLFSVCHILLLVHPTCSFDITYDRVFRALDGLRQKVLPLLKTAIKDCPVGKDWKLNCRPCPPRLLFLFQLNGALKVEPPRNQDPAHPDKPKKHSPKRRLQHALEDQIYRIFRKSRVLTNQSINCLFTVPANQAFVYIVPGSQEEDPVGMLLDQLKSHCTVKDPESLLVPAPLSGSRRYQVMRQHSRQQLSFHTDTSSSSSSGQLVDFTLREFLWQHVELVLSKKGFDDSVGRNPQPSHFELPTYQKWISAASKLYEVAIDGKEEDPASPTGELTSKILSSIKVLEGFLDIDTKFSENRCQKALPMAHSAYQSNLPHNYTMTVHKNQLAQALRVYSQHARGPAFHKYAMQLHEDCYKFWSNGHQLCEERSLTDQHCVHKFHSLPKSGEKPEADRNPPVLYHNSRARSTGACNCGRKQAPRDDPFDIKAANYDFYQLLEEKCCGKLDHINFPVFEPSTPDPAPAKNESSPAPPDADADKLKEKEPQTQGESTSLSLALSLGQSTDSLGTYPADPQAGGDNPEVHGQGEVKTEKRPNLVDRQASTVEYLPGMLHSNCPKGLLPKFSSWSLVKLGPAKSYNFHTGLDQQGFIPGTNYLMPWDIVIRTRAEDEGDLDTNSWPAPNKAVPGKRSAVVMGRGRRRDDIARAFVGFEYEDSRGRRFMCSGPDKVMKVMGSGPKESALKALNSDMPLYILSSSQGRGLKPHYAQLMRLFVVVPDAPLQIILTPQVRPGPPPCPVFYPEKQEITLPPDGLWVLRFPYAYVTERGPCFPPKENVQLMSYKVLRGVLKAVTQ
The following text describes a protein:
Function:
Required for normal heme biosynthesis.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MPKDSGPLVPLHWLGFGYAALVASGGIIGYAKAGSVPSLAAGLLFGGLAGLGSYQLSQDPKNIWLFLVTSGTLAGIMGMRFYNSRKFMPAGLIAGASLLMVVKLGISALSKPHQ
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSGPAPVTAPPLTIFYDGRVVVFEDFLAEKAVEVMRLAAGDDLPIARKATLQRFLAKRKDRLVKRVALHPPIVPHGGAGEEDGQAGLGLGHMLDKMTV
The following text describes a protein:
Function:
In higher plants aldehyde oxidases (AO) appear to be homo- and heterodimeric assemblies of AO subunits with probably different physiological functions. AO-delta may be involved in the last step of abscisic acid biosynthesis, at least in leaves and seeds. In vitro, AO-delta oxidizes abscisic aldehyde to abscisic acid (ABA). In vitro, AO-delta also uses 1-naphthaldehyde, indole-3-aldehyde (IAld), benzaldehyde and cinnamaldehyde as substrate; the AAO2-AAO3 dimer also uses abscisic aldehyde as substrate.
Miscellaneous:
MISCELLANEOUS: In vitro, cannot discriminate between (+) and (-) enantiomers of abscisic acid and leads respectively to (+) and (-) cis-ABA.
Subcellular Localization:
Cytoplasm.
Sequence:
MDLEFAVNGERFKIDSVDPSTTLLEFLRLNTPFKSVKLGCGEGGCGACLVVLSKYDPELDQVKECCINSCLTLLCSVNGCSITTSEGLGNTKKGFHPIHKRFAGFHASQCGFCTPGMCISLYSSLANAENNSSKDFTVSEAEKSVSGNLCRCTGYRPIVDACKSFASDVDIEDLGLNSFWKKGESKEVMFKNLPPYNPKDHLVTFPEFLKKKEKVDNGSDHLKYRWTTPFSVAELHNIMEAANSGDSLKLVVGNTGTGYYKDEERFDRYIDISNIPEMSMIKKDEKGIEIGAAVTISNAIDALEKESKSSYVFKKMATHMEKIGNRSIRNSGSIGGNLVMAQSRKFPSDVTTLLLAVDASVYMLNGRKTEKVTLQEFLELSPVLDSKRVLLKVEIPSWTAPSGDDTEFLFESYRAAPRSIGNALPYLNAAFLALVSRQEASRKGVTVEKCFLAFGSYGGDHSIRAIEVETFLTGKLLSYSVLYEAVGLLKGIIVPGKDTLHSEYRKSLAVGYLFEFFYPLIESGHRICSLDSGNKHNNSHVDTVKSLPFLSSSQQVLESNEFKPIGEAVIKVGAALQASGEAVFVDDIPTLPDCLHGAFIYSTEPLAKIKSLSFRENVTPTGVFAVLTFKDIPQQGQNIGSKTLFGPGPLFADELTRCAGQRIALVVADTQKHADMAAKLAVVEYDTKNLEQPILTVEDAVKRSSFFEVHPMFYPEPVGDVIKGMEEAERKIISSELRLGSQYFFYMEPQTALALPDEDNCVKVFSSSQAPEYVHSVIATCLGIQEHNVRVITRRVGGGFGGKAVKSMPVATACALGAYKLQRPVKMFLNRKTDMIMAGGRHPMKINYNVGFRSDGKLTALELTMLIDAGLEPDVSPIMPRNIMGPLRKYDWGALSFDVKVCKTNCLSRTAMRAPGEVQGSYIAESIIENVASSLQMDVDAVRKINLHTYDSLRKFYNHIAGDPDEYTLPLLWEKLEISSKFKERSEMVKEFNLCNVWRKRGISRVPIVHQVMQRPTPGKVSILSDGSVVVEVGGIEIGQGLWTKVQQMVAYGLGMVKCEGNEKLLDRIRVVQSDTLGMIQGGFTAGSTTSESSCEAVRLCCVILVERLKPIMDQMMMEKSGSVTWNILIQQAYGQYINLSASTLYKPEYSSMEYLNYGVGVSEVEVDLVTGKTEILRSDIIYDCGKSLNPAVDLGQTEGAFVQGIGFFMMEEYTTDEKGLVVQQGTWDYKIPTVDTIPKHFNVEIVNTGHHKNRVLSSKASGEPPLLLAASVHCATRSAIREARKHSLSSNFIDGSDSEFELPVPATMPVVKSLCGLYSVEKYLQGKIKGQ
The following text describes a protein:
Function:
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Sequence:
MSKVILKIKRLPHAQDLPLPSYATPHSSGLDLRAAIEKPLKIKPFERVLIPTGLILEIPEGYEGQVRPRSGLAWKKGLTVLNAPGTIDADYRGEVKVILVNLGNEEVVIERGERIAQLVIAPVQRVEVVEVEEVSQTQRGEGGFGSTGTK