lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.
Subcellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin. Associates with membranes via the adapter protein complex AP-1 (By similarity). Colocalizes with AP1G1 (By similarity).
Domain:
The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2.
Sequence:
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVSGTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGESFAEFRSAGTDDGFTDFKTADSVSPLEPPTKDKTFPPSFPSGTIQQKQQTQVKNPLNLADLDMFSSVNCSSEKPLSFSAVFSTSKSVSTPQSTGSAATMTALAATKTSSLADDFGEFSLFGEYSGLAPVGEQDDFADFMAFSNSSISSEQKPDDKYDALKEEASPVPLTSNVGSTVKGGQNSTAASTKYDVFRQLSLEGSGLGVEDLKDNTPSGKSDDDFADFHSSKFSSINSDKSLGEKAVAFRHTKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAADIEDLKYAAFGSYSSNFAVSTLTSYDWSDRDDATQGRKLSPFVLSAGSGSPSATSILQKKETSFGSSENITMTSLSKVTTFVSEDALPETTFPALASFKDTIPQTSEQKEYENRDYKDFTKQDLPTAERSQEATCPSPASSGASQETPNECSDDFGEFQSEKPKISKFDFLVATSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLNEKPALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALNVIKKANDTLNGISSSSVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLATLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEEKPAEEHPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLVLPDLL
The following text describes a protein:
Function:
In the de novo pyrimidine biosynthesis pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate with reduction of flavin and the transfer of electrons to ubiquinone, which is part of the respiratory chain. Does not use fumarate and NAD as electron acceptors.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFRPSIKFKQSTLSIIARRLKSSAQHQPLRSSFVPSPIVFVAGLAVAAVGGYYCLDSRSAIHEYVLCPLIRTFTDAESGHKLGIFFMKYGLSPRLLDDGKNDQSDVLGVQVFGHKLKNPIGLAAGLDKDGEAIESLFNCGFSYVEIGSITPEPQPGNPQPRFFRLPKDDAVINRYGFNSSGHFNVLATLKLRFNKLLNKFGTSHSSEQHPFSNAFQQGKLLGINLGKNKFGDEVNDYVKGVERLGPYADVLVINVSSPNTPGLRDLQSEAKLTNLLTTVVKERNVLGKNLLGNKPPVLVKVAPDLTEPEIESIANSAKEAKVDGIIISNTTIQRPVDRLLTTDKQLINQAGGLSGKPLKPLSLKALRTLRKYTKDSDLVLIGCGGISNGKDALEFGKAGATFIELYTAFAYKGPGLVGKIRDELAEELRKEGKTWEQIIGSDDK
The following text describes a protein:
Function:
Involved in the oxidative stress response and detoxification.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLGTLYSFKTNTRTVCLLELAKLLDLQVDLVETYPHKFSADLAAKFPLQKLPVFIGADGFELSEVIAIVKYFYEKGKHNDKEGLGPVNEVEEAEMLKWMCFINFDIVTPQNVRPWVGMFRGNIPYEEKPFKESATRAIDSLKIPNELVKDRTYLVGDRFTLADLFFGSLLRIFFNSIIDEKTRKELPHLTRYYITMFHQAKLETYFPLELPLTVTVAKK
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MDIRIKEKPEEFYVKEIKKLDLKEKGQYAYFLLKKKDMTTLDAVRHISHRFGIPLKNIGFAGLKDKKAVTEQYISVKDLNEEKIRKMDGYRTENLELKFLGFSDKGLELGEIEGNYFEVVVRGVTKYHRRVFPRMKELVENYGCENYFGEQRFGSVKHAEEFIVKYLLRHEYEEAMKEYLTSLGDKRLKRLLRKAWRDWDRFLSLMPKGAKPELEVVKALRRGESFKNAFMVLPKNIRLMFVFAYQSYLWNRYLYTFVVRYLKYCKTPFLKWELAFFNDMSEVIWEEIKDLEIPYLGVEYKPRNKKAEIVMKEVLQDEGITPKMLMAERIGIKLFSDGVRKAFFKPQGLKVIEERKNSLKLSFTLPPGSYATILLRKLFCSDVKS
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSENVYLNEALNVVDQCFKTFFDKYTDRMGSAFACSGTIDKDHIFLVWSVAVYAEAMADSLRYTSKFERKFEHVFQALKKYWSPVFNACCAFHYFEGNDDVYYDDNAQVAIGLATAGYYTTNSSRRDHYVSRAESIISLIINKGWNQQRGGIAWHTRTTGPPWTNLNACSTSMSAVAALRLALALDDPNKKQHLVSFAWNCVRWIQENLLDENHIVCDGLSLKDGKWVLDKARFTYNTGTTMTAMSLLMGLGEFTKGLQDIEKLPTYLEDMARGALDTNGPLYDQSCNGSFKVWSDNTFFAQHLSEGLMTFSYAMPSSALAKPAQKMVLDQADFLMKYLRIPKEGLYYRNFGLYKLSPELTASFNKFFNANKQFQPDKDERIQQEGPVEQRPLCPTLIGSAGAARMLFSAAEIVNRNNPSSGESTTLPQPSHGKKDKDCVIS
The following text describes a protein:
Function:
Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein.
Sequence:
MCRSLRYCVSHCLYTAMTRLEEANREVNMYSSVRYLGYLAQLSLLVAICMGLYVRWDQTDDSFILVIFILGLVIFAIASILYYYFSMEAASLSLCNLWFGFLLGLLCFIDSSTFQHDLKEEATKYLLVSSIIIKTLSALVERICGCVRHRPTLLTSSEFLELVGFAIASTIMLMQKSLSIILLVAALAMIIIDLRMKSFLSIAILVVFASLTPELFFRSLDIPVNPYALSCFFFCIISNPFLDVYFSGLSVTERWKPYLYRGRFCRRFSVISIGLIELVFFVFAALKLGDLHLWYFVIPGFSIFGIFWLICHIIFLITLWGFNTKLNECHKVYSTHRPDNNSLDRVMASKGMRHFCLISERLVFFSLLATIILGAVSWQSSNGLFISIFLIVLPLESMAHGLFHELGNCLGGTSIGYAVVIPTNFCSPNGQPMLLPPEHVEELNLRSTGMLNSIQRFFASHMIETYGCDYSTSGLNFDTLHSKLKSFLDLRTSDGPRHDTYIIYYTGHSHSTGEWALAGGETLRFETLLEWWREKNGSFCSRLIIVLDTESSQPWVKEVRRVGDQYVAVQGAEMARVVDIEEADPPQLGDFTKEWVEYNCNPDNNINWTEKGRTVKAVYAVSKPWSDYTLHLPTGNDVTKHWMTYFPHITYPLVHLANWCGALNMFWLCKICYKCLKRLKMNWFLPAVLDTGQGFKLVKS
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTLYYSLVFCLLVFEMAVFMGLIIPLPFTVKRKLFTFISESPLVAKLQYGMKITFIFILILFIDSVNRVYRVQLELASFTKEGNSMGAAALGTDRMEVQARKFYSQRNMYLCGFTLFLSLILNRTYTMILEVLRLEDRVKHLEGDKKAGGKDSARLAQAGDIGEIARLRKEIEAKDLDIETLKKQCEGLTREYHSLGDRVTGTTNDGSKKDL
The following text describes a protein:
Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MEEGHQKYRTELPKPVRAQLDKQDQYDLKQLRQALRGDRPSGQVVKSAAAKPLMPKNGAQDLVSSLANRLTKVEAENQQLKLMLRRANDENTSLRQKVDLCRLAAAGEQANVDEIMALKDYIEVLRQQIYDMELFLDSHGLIYVEDTDSSKEPAPRAVQHTLQLDHIGDSTETWEPPERHILEDNIRKLNQLVSKDRVLVADGGNQGRYGDKPSIPVRFYPNGIFIKRGPFRAYEHDKTAKEFVEDIAAGFLPSEFRASHPDGISIDASFEAEPFKSCGVELFEGQAKLMIDESAQPPPPPKPAKSTIEAAAEHGSVKRSYLTVSEYGNRHNYSYDQLLDQRANLEKPMSLQQFLSRVKGTCVSNGQIVPMKEALGLLVHGKTPAEQAKEAGKDNLSSTTIVTETADDGRVATLRIRVSSPDSALNDHHLLLKLPFSYTIESMIERIGDALNIDCGRIRLHRPFGDDIMQDVSATLESAGCTPNARLFAKIGA
The following text describes a protein:
Function:
GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.
Sequence:
MTCSWQFTRKVCSQGGGQRGVSRSTSQWALSHIKELGLCPEVGVQKRKDCKQHWQDGLGCALEHRLEDLAWKQLQDPSLMNEVVHTCPTIGSNVEEIVLQNTHFLMWDIGGQEALRSTWNMYYSNTEFIILVIDSTDRDRLLTTREELYKMLAHEALRDASVLIFANKQDMKDSMSTVEISRFLTLSAIKDHPWHIQGCCALTGEGLPAGLQWMQSRTTAN
The following text describes a protein:
Function:
G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTRHVWFSLPYASKPFRRTAASNSSGIFSTLYGFPNISSLFNGDLNIDDIGDFENDTKYEAESQSSTVKALLIVAYSVIIVISLFGNILVCHVVIKNSRMQSATSLFIVNLAVADIMITLLNTPFTLVRFVSSTWVFGKLMCHVSRFVQYCSVHVSVLTLMAIALDRHQVIMHPLKPRMSTVKGIICIIVIWFMASGFSLPHAVYQKLEQFFIGNTVRMVCLPSFPYPADLFWKYLDLATFVLLYVLPLIVISITYTTVAKKLWLRNAIGDITMEQYYAHRRKKKMTLKMLMLVVVVFAVCWFPLNCYLVLMSSKVISSNNAIYFAFHWFAMSSTCYNPFIYCWLNESFRSELKALLCVCRRRSPAQSHPLQSVSPQFRHAWTENCHFKQGSSSQAAGSATNVNSGRTDISSVEPIVTVS
The following text describes a protein:
Function:
Involved in intercistronic processing of primary transcripts from chloroplast operons. The endonucleolytic activity of the enzyme depends on the number of phosphates at the 5' end, is inhibited by structured RNA, and preferentially cleaves A/U-rich sequences.
Sequence:
MARQMARLAQQDAVQARVAEQRRREALRQAEFREELEREGKVAKDAPIPAELAKLKGVKKGTKEGDEGEEVVEGKGDEPETERRTEAPDAGPKVRREIIINAARTSMPRVAILEDGRLAEMLLEQEKQVSVGDVLLAQVTAKVRAMAGLFVDVTVYKKAFLQAYNHHRPYVFRRLPNGSVEAVGGGDEDFGDGTDSGVGAEFGDGVEELETGSGSGKEAERNGTGRKEAEAGASDEEEEGGDDGEDDVMTEEGDEEEELQLGEEGGEDGDEDEKGESGDAEGKEGGGKDGHVALRQSGWTTSRNWQDVEVGDFVVVKCTKESYGSKGPKVSAVLSHPGRFVVLTARSDGVHISAKIRSGDERKRLETLGKLLKPAGYRLLLRTESKAAQGKEIQQDIYQVQTVIEGILRKAEEAVKRNTGALLLYKAMTPTQAIVRDLMSTEVVRLVVDTPEVHAQVMSYLAENNSEHLMNRVELYSGKQGVMDAFGVEGQINSIFQSRVQLESGAYLVIQKTEALWSIDVNGGRAVTSGNRTRAEAQSETHLRINLEAARQVAKELRARDVSGIVVIDFIDMASPAMNVQVEKAMWEALQTDRARVKMGKINEPGNCMQILRSRLRDNLANLLTAPCPLCTQDFHSVSAGRIPSREAVVAEIERTIVRKEADGSIPRTPGSAERPESNGRNPTWPTIFLTVHERVEQFFLGANLKRLNTTMAALRVNINVMVPDSPIREYDFQIQLSGRSEPLFDSAKDRKDSADRSSSEKAWGGGRKLAHNPEAHVIDVSPEEDDVSTTRRGAASKRRGAGEAEGAEEGGARRGYVYRKRDDVSERRKDDVSERRAEDVGERRRADVSERRRESAAETRREKGSERRLGDVSERRRDDVSERKREDISVQKKDTVSVNKKDKSTERKKDAVSERPTVRVSFTDGGGFESGEEDRKERRRKPAERGRKEPDSEKPAERPAVNTPQISPLAELLVSQESQPTIWSKVRPTKGPVRTQVDAAKQKESENGARTGPQKTVAENEVRGEVGGEALSGTGETVIEVQMANSRGKDAKRQGPSKTTSDMGVPNEAVSSAQNGALLEKLDTAPRADAGAVAPDDIIEEGSDADEFWGADVSRVAGEEAAESMTSAPETPEESSTEGSPNGADVSNGARADVISDADVSDGEGSGAKERAAGARRIRRGKKARAQGEKQLPEDVRRAEPEAGTPERTEPDVGVRAGSDLDLMMESVQVFQKVTKLSPDKIAKVGSVGSQIMTVLAENDVTGAGEPWNFLQWYSGERSGIPPERAERYAEVVPLLQGVVDQSVDDEDWSELHTELFESPDGNENGDLFGDGPPTIPAELLPMLGLADWSGALDLVLDSTVGKGVRDGESGNVAQGVYDVSGENGRDDRAERTSLGAEGSDGLSDDDVAPPAAQTSNVMTRPVVRAVPARPGPKVGAGNPSARPKRKGRQKKK
The following text describes a protein:
Function:
The chloroplastic ME isoform decarboxylates malate shuttled from neighboring mesophyll cells. The CO(2) released is then refixed by ribulose-bisphosphate carboxylase. This pathway eliminates the photorespiratory loss of CO(2) that occurs in most plants.
Sequence:
MESTLKELTNGESVLDIKDKCGVAGGVEDIYGEDRATEDQTITPWTFSVASGYSLLRDPHYNKGLAFTEAERDAHYLRGLLPPTVSSQQLQEKKVMHNLRQYQVPLQRYMAMMDLQERNERLFYKLLIDNVEELLPVVYTPTVGEACQKYGGIFRRPQGLFISLKEKGKILEVLKNWPEKSIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYTALGGVRPSVCLPITIDVGTNNQKLLDDEFYIGLKQKRATGQEYAELLEEFMSAVKQNYGEKVLIQFEDFANHNAFELLAKYRTTHLVFNDDIQGTASVVLAGLIASLKLLGGTLADHTFLFLGAGEAGTGIAELIALEITRKTSVPLEEARKKIWLVDSKGLIVSSRVESLQHFKKPWAHDHEPVKELIDAVKAIKPTVLIGTSGVGKTFTKEVVEAMASLNPKPLIMALSNPTSQAECTAEEAYTWSKGHAIFASGSPFDPVEFEGRTFVSGQANNAYVFPGFGLGIIMSGTIRVHDDMLLAASEALASEVTEDDYLKGRIYPPFTNIRKISAHIAAEVAAKAYELGLATRLPRPSDLVKYAESCMYTPLYRSYR
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MASCSTSGTCGSSCCQPSCCETSCCQPSCCQTSSCGTGCGIGGGIGYGQEGSGGSVSTRIRWCHPDCHVEGTCLPPCYLVSCTPPSCCQLHHAEASCCRPSYCGQSCCRPACCCHCCEPTC
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKKAIITSALPYANGEIHLGHVASTYLPADVTTRFLKQNGVEAYYVCASDDFGTPILIQSEKEGKTPAEYVAHWNKRDYEDFSAFDIDFDYFYKTSSDENIQFVQDVFKKLNDAGHIYEQEIIQFYCNNDKKFLPDRYVKGTCPYCKAEDQYSDLCESCGRVPEEITNPKCSLCGQPPTKEKTTHYFFKLKNFGEPLSKWLDENDHLQKDVKKYVQNWIKSGLIDWDITRDITWGVPVPLDDAKDKVFYGWFDNHLAYISTALKFLNDKGIDGKEFWNSADIYHFIGKDIVYHHYLFLPAMRLGIESEYKLPDYIPTRGHLTLQAKKISKSRNWYIGLKEFLEYYPADYLRFYLVSINPYSQDDLNFDWDDFTTRINSELIGNLGNFINRALGFTKKAFDGNIPDPEDFDEKDSEAEQKIKSLASEVGSLMEQNHLDRALKKIMEFSSYFNQYFQHKEPWKKGPGTASCVYLSVNAVRSLAIATFPFIPKSAQNIWTQLALDGKINDQNWNDMSVLGVSSGHTLGDASPLFARVEDADIEKYKKQLGPSE
The following text describes a protein:
Function:
Catalyzes the oxidation of aldehydes to the corresponding carboxylic acids by coupling the reaction to the reduction of dioxygen to hydrogen peroxide. Substrates include, methylglyoxal, glycolaldehyde, acetaldehyde, formaldehyde and glyoxal. May act as a source of extracellular hydrogen peroxide required for the oxidation reactions catalyzed by the lignin peroxidases (ligninases) and manganese peroxidases, both involved in lignin degradation.
Subcellular Localization:
Secreted.
Sequence:
MLSLLAVVSLAAATLAAPAASDAPGWRFDLKPNLSGIVALEAIVVNSSLVVIFDRATGDQPLKINGESTWGALWDLDTSTVRPLSVLTDSFCASGALLSNGTMVSMGGTPGGTGGDVAAPPGNQAIRIFEPCASPSGDGCTLFEDPATVHLLEERWYPSSVRIFDGSLMIIGGSHVLTPFYNVDPANSFEFFPSKEQTPRPSAFLERSLPANLFPRAFALPDGTVFIVANNQSIIYDIEKNTETILPDIPNGVRVTNPIDGSAILLPLSPPDFIPEVLVCGGSTADTSLPSTSLSSQHPATSQCSRIKLTPEGIKAGWQVEHMLEARMMPELVHVPNGQILITNGAGTGFAALSAVADPVGNSNADHPVLTPSLYTPDAPLGKRISNAGMPTTTIPRMYHSTVTLTQQGNFFIGGNNPNMNFTPPGTPGIKFPSELRIETLDPPFMFRSRPALLTMPEKLKFGQKVTVPITIPSDLKASKVQVALMDLGFSSHAFHSSARLVFMESSISADRKSLTFTAPPNGRVFPPGPAVVFLTIDDVTSPGERVMMGSGNPPPTLE
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MYAVYKQAHPPTGLEFTMYCNFFNNSERNLVVAGTSQLYVYRLNRDAEALTKNDGSTEGKAHREKLELVASFSFFGNVMSMASVQLAGAKRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLIYGTRLVVLPFRRESLAEEHEGLMGEGQRSSFLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIGGVVIFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQAAFISYDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSLLLKYTEKLQEPPASSVREAADKEEPPSKKKRVEPAVGWTGGKTVPQDEVDEIEVYGSEAQSGTQLATYSFEVCDSMLNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGYGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEETPKAESTEQEPSAPKAEEDGRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLALHKPPLHHQSKVIALCLYRDVSGMFTTESRLGGARDELGGRSGSEAEGLGSETSPTVDDEEEMLYGDSSALFSPSKEEARRSSQPPADRDPAPFKADPTHWCLLVRENGTMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEVRKEEATRQGELPLVKEVLLVALGSRQSRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGCSTEEGSGGRGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMGIDGPIDSFAPFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCTRIPRMTGEEKEFEAIERDDRYIHPQQEAFSIQLISPVSWEAIPNARIELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGAAEGPSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVTAHF
The following text describes a protein:
Function:
Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade. In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86. Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway. In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation.
Domain:
The TIR domain mediates interaction with NOX4.
Sequence:
MMPSFCLAGTLMMALFLSSLRPESLDPCVEVDSNTSYQCMDRNLNKIPDNIPSSVKHLDLSFNPLKTLGSHSFFNFPELKLLDLSRCEIETIEDKAYQGLHQLTTLILTGNPIQNLSKGTFSGLANLQNLVAVEIKLASLDSLPIGHLVTLKKLNVAHNLIHSFKLPEYFSNLTNLEHLDLSNNYIQTIYYTDLQTLRENPQLNLSLELSLNPIDFIQPGAFQGIRLHELTLRSNFNSTNVMKTCIHNLDGLQVHRLILGEFKNERNVERFDRYVIEGLCKVTIEEFRFTYANEFSEDITDFDCLANVSAMSLANVYLKRLEDIPKYFKWQTLAVIRCELKQFPPLELPFLKRLIFITNKGATSFPEVNLPSLTFLDLSGNGMSFRGCCSYTDLGARSLKHLDLSFNGVISMSENFMGLEQLEYLDFQHSTLKKATEFSMFLPLEKLLYLDISYTNTKIDFNGIFFGLTSLNTLKMAGNSFKDNILSNVFTNTTNLTFLDISKCQLQQVSWGVFDTLHRLELLNMSHNNLLLLDLFHYKQLHSLKTLDCSFNHIETSKGIMQHFPKSLAFLNLTNNPFACICEHQNFLQWVKDQRLFLVKTEQMTCATPVEMKDSLVLDFRNATCYVQKTIISVSVISVLVVSTIAFLVYKFYFHLILIAGCKKYSRGESIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSHSGIIFIVLEKVEKSLLKQQVELYRLLSRNTYLEWEDNALGRHIFWRRLKKALLDGRAWNPEGATEAENNQQETTTSI
The following text describes a protein:
Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Subcellular Localization:
Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MEPLWTPLLGLCYLLAAATADRHTVFWNSSNPRFQSKDYTVYVQLNDYLDIVCPHYEDEAAASGRPLERYTLFLVEREDYVLCHPSSRDQVRWQCSHPTARHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISEPLHETLEAPCLKLKVTVSDRTSHNPPLDAETKKEPGLPADDPDAQVLHSVGHSAAPRPCPLAWSMLLLPLILLQTP
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal zinc finger binds to poly(A) RNA; Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs; The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.
Sequence:
MLPPPKSAAVQIVRPPSPSSEKAKEKEKKHSPEKRETAQRICRNVMIYGYCKYQDQGCIYYHPPAGADPSTPQNSSPVAHAPTPSAPTPLAGTPAREKPTLSIEHLAAPVFVPKGLDSSPRASTPSVPTPSAPTPPVWPSLPSTGLLPRQDVQVSAQPSHAQLSATASPMAYDDPSHIALSAAHAHAQAQALTHGILDPHAHAPPVDQSMYLPPRQPLDYNLYAAPLPSIGGNPLYPTHPHAFFVSDDLRRAIQAKQEAVYAGANGASAPGLPQELGVYHSLIPLPLPAPTAQCPPTQSQPSKVYGLPSPVYRATSEVDGNTYCLRRVEGFKLVNQLAFASMDTWRRMRHPNIVGLKEAFTTKTFGDNSLIMVYDYHPLSTTLYDEYLSPNPPEPSPASALANQPPKRRSSPPERILWSYVTQIANALKAIHSSGLAVRNLDASKILLTGKNRIRLNGCGVWDVLAFDNKTPVQAFQQEDLLSFGKLIISLTCDFFQPTLPFSLPLEHISRHYSSDLSNLILYLISKPAQGQIKSIDEVVKMMGPRILNELDAVQSYADVLENELGAEVENGRIVRLLTKLGFINERAEFELDPRWSDTGDRYILKLFRDYVFHSVGVDGKPILDLSHVLVCLNKLDAGLDERVMLVSRDDQSCLVVSYREIKHCIEAAFNELKNAGNNHRVHR
The following text describes a protein:
Function:
PP2C-like phosphatase that can dephosphorylate YegI. In vitro, can hydrolyze p-nitrophenyl phosphate (pNPP) to p-nitrophenol.
Sequence:
MSWRLVYASTVGTSHISADLPCQDACQMQIAWLNDQQPLLSVFVADGAGSVSQGGEGAMLAVNEAMAYMSQKVQGGELGLNDVLATNMVLTIRQRLFAEAEAKELAVRDFACTFLGLISSPDGTLIMQIGDGGVVVDLGHGLQLPLTPMAGEYANMTHFITDEDAVSRLETFTSTGRAHKVAAFTDGIQRLALNMLDNSPHVPFFTPFFNGLAAATQEQLDLLPELLKQFLSSPAVNERTDDDKTLALALWAE
The following text describes a protein:
Function:
Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock. Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cortical endoplasmic reticulum.
Domain:
EF-hand domain is involved in the detection of calcium concentration.
Sequence:
MNEHRREPHRRSGYQDDSAFTNTEKLVDELDHNVEPEQLLEKNRTDFKLMYVIVKFYRWFNNLSFITRWITIWFPLAGALVIPLAVGVSPYPNAKLGGVRIFWIFVWLEVAWGGFWVSRVIARLLPYILYPLMGILPFTMYKYTVILTALEMPLAIFFCSIVCVCTFSPIMIGKGNFTSTTVTTTTSATATPTASASSNAVESVFVTKTAASVPSWIKVITKILGAAVVTSIVLLLEKIFLHFIGFHYHEVQYQYRITDNKRNTAVLAKLLTAALDAPYHDSPRVRRQDYLLGLIDTRSMSESKGSGNGKLRKVKKISKNAKRIFSKTRNAISTAFTDMLGKHAKDLTPEQEFILETIRSKKKCLALARKIWYSLVPEGEDCFQKEDLIGLIPDDEINDIFHILDNDYSRTVTLDEMEQFTREISIEFRSISSSLRDVDLALGKLDRVGLGVVGIIAVLTFISFLDTSFATILAAFGTTLLSLSFVFSTSAQELMSSIIFLFSKHPFDISDVVIVNNIKYEVVSLSLLFTVFRTMGGSTVQAPNSLLNTLFIENLRRSQPQSETITIVSPFATDFKQLERLRDLLLTFVKENERDFRPIIDLNVSDFSTLDSLKFTVTYYYKSNWQNVSLQCVRRNKFMCALKNAIATTNLPAVADPVRGSPDYPFVIEQYNLERPEYSKTASRPQFSDISSTASSNSLSNKPGFAHSESRNYHTHDEDNSSDDNHKREDRGHLPAQYLRQSVATWQIPNLISAIEAYDSQNESSQENATYTVVESNGNANGDNTATNSQGATDNGQTTTNTTQNNVDNTQATTDNTQANTDNMQVAIDYSQNMDGQIQY