lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Synapse. Presynaptic cell membrane; Peripheral membrane protein.
Sequence:
MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAESQPHQPPLNIFRCVCVPRKPSSEEGGPDRNWRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAVSSQDTASHGAPLDRNKGAEPSQQALGPEQKQASRSRSEPPRERKKAPGLSEQNGKGGQKSERKRVPKSVVQPGEGTADERERKERRETRRLEKGRSQDYPDRLEKREDGRVAEDEKQRKEEEGVSTPEYTSCEDVELESESVSEKGDLDYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKLLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQDEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRASARESKATTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSLADHRSRHAESQYSSEPDSELLMLPRAKRGRSAECLHMTSELQPSLDRARSASTNCLRPDTSLHSPERERGRWSPSLARRRPASPRIQIQHASPENDRHSRKSERSSIQKQSRKGTASDADRVLPPCLSRRGYAIPRATDQPVIRGKHTTRSRSSEHSSIRTLCSMHHLAPGGSAPPSPLLTRTHRQGSPTQSPPADTSFGSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDHEQYSKYNIHKDQYRSCDNASAKSSDSDVSDVSAISRASSTSRLSSTSFMSEQSERPRGRISSFTPKMQGRRMGTSGRAIIKSTSVSGEIYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRVGPDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSSGPPCIRS
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MRPSGLFPGEGEANEVEQTEDHTGQRWGSPSPKERRIAYDSVDPFCRLQKRKATLVDDAAPSSEWILEYSQEILALLGPRDEPHGLSSRSDDDDNDMHDDDQEEEPGPAPPLAVRLPRAAWELIELFYLGGRPSSSVAEDLVEWLRGNHSVLPDPPPGRKNAHTRIQELRTKLKTRPAEDLPEYWEAIAAILAVGWIDAAVFLLKQLASFSPEDSNLELERGLIEGLAILVEQIPRLRAEGEQDHPSVPTFLKARESWKGKIQKLLTSQYVAKCRTVARTGLELVRTVLAGEKDGLKRSTGHWAELLAAHLFHRRPNMRAQLEIQRLAEACIVEAGLSGRDDESMTPFDKITLAILGGETEEVLSLSARTFRPWFLAHVTEVLAASGERVHTLLQEPREGLGGCGLEESFRLQYAEDVAAEDATWQNAPFYLAQCPVLGRGTLETLLIRRSASAARDPDVLKLLDICRQYGLDEAAVKICRNVGVQRWERKQRGSAIAWLQRGRDDKRLNAIAHELIEEVTNAEGEGLDAIGLLLDNVSTALPLSGSLAFLQRYRKLQATLALLRSPPAEGLPAQLRAAGETIVALLTPGMAPRQFWLTILFDAIPLLEWPGFTVFDSRQTFHLMACLEELRTSHLHDEYLKKGGEAIDELTLQRLDLALATNLGRAFVKDANRT
The following text describes a protein:
Function:
Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate in diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EFT1 and EFT2). Also plays a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Identified in a screen for mutants with decreased levels of rDNA transcription.
Miscellaneous:
MISCELLANEOUS: Present with 2640 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endosome. Note=Recruited to endosomes in cells in which increased recycling of internalized plasma membrane proteins occurs.
Sequence:
MDSIQESDVLNAVKTKLPPCCLRIFRNKIILVGTYDLDKSTGYRSGSLDVFTMDLKLLCSNNTYGAILDLKLSPFDDTLICTAHSTGNIMLWRIRCTDKDDFQSNELDIHAIANLQLFEKDVLIASCHFSPLDCKKLLVTNTAGEAATIDIRTLSVQFTASAIAQAYSKLDKIDYEVQGATEKVIHVESGQFLKPHELECWTAEFGSLQPFQDVVFTGGDDSRIMAHDLRSKEFIWSNNRIHDAGVVSIKCSQPNFRNNKPTSIITGSYDDNIRSLDLRMMGESIFPGANVPTVNKLACDLGGGVWRFVESPIDQEQSHHNGSDRLLVCCMYNGAKVVTMNDNSDEYFQIQHYLKKGHDSMCYGGDWSNSLIATCSFYDNSLQTWIV
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MGDGSDAERSGGTSSSSALELLAQYEQHIMERGRTLEAIEGHGGERLGPTYEELVEENVQLRRELQGQREEIEHLRKTISLLASGRSGATVVEQQVRPEPSPSVRELALPPRSADRRKNTKNLSLAPVGHEVPSTDRLRVSPQEATSGAQQVPLLTSSKSAEILVSKSPDEDRHLMSPRKTISRSSSSYSNTLGSPATSVLYKNSRISITSPCKSNSTSKAASVLSLPENNTSTENAPHSPHRIDNELDLLTVEPQDGSRYDTERAGGPGPLSPESIVYSDSDLQEHQPSDLSSTTRTDLGKFRDMVDTTFNAEDNPTGSRDKETGTEMEIATLQNTPSRQHESSLVTSPQASRSSITTPVVDPTNTSEPSSLSAAKFGSMSTATSSNKRSKGMGTPSVEHSAKSYSQHSGSPHSNSHQSKKADIPLFVQPEELGTIRIEVISTLYHEPGNAASILFSVVDKKSSKEMFKFAKTFTRIAEFDTFIRNNMESLAVPPLPDKHMFASNVPVKVDSRREKLNDYFASLLYLSPLPFNPALKLAQFISTDPVMNPITGEFAKEGMLLVRKSKTLGSTTTWRIRYCTVEGSIMHLHDHMIDTDTIKLTHSTIELQANLPDDKYGTKNGFILNEHKKSGLSSSTKYYFCAETPKEREQWISVLTTLCDGPGGTAAIPSINSKSEASSLFEQTSISDSSYLGPIANLEAMDATSPTRPNDPNPVSLTSEEEKEVKRRRMKSFFPFKKLATTPTPYAAGNDNASIFSQDDDSPVNATNESGISRSLQSMNLQAQYNAVFGADLRSCLQLSSHPYQGKYEIPSVVFRTLEFLYKNRGIQEEGIFRLSGSSSLIKSLQEQFDKEYDVDLCNYNDKVSVTPGNENQGGLYVDVNTVSGLLKLYLRKLPHMIFGDAAYMDFKRIVERNGDDSKLIALEFRALVNSGRIAKEYVALMYALFELLVKITENSKYNKMNLRNLCIVFSPTLNIPVNILHPFITDFGCIFQDKAPMENGPPVNIHIPQI
The following text describes a protein:
Function:
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MELHILEHRVRVLSLARPGLWLYTHPLIKLLFLPHRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAKHHVSVLMLSTYQTDFILVREQDLSKVIHTLAQEFDIYREVGGEPVPVARADSSNGFPRAQHGEGRPLTPKPGRGLLFPLRPFPCAGGSVGMGRPADTASQDGEMGRGKLQWVLVEHDPAFSPGPTRGRPSPRLPFHLSLPGPSLAGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSAPKEAASGSPGPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLGS
The following text describes a protein:
Function:
Transcription termination factor required for processing and steady-state levels of plastid transcripts. May play a role in response to abiotic stresses.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAGFSLYCFKNPRILFTLPSESPLFVLGSDKCSPATRRPSRKTRGFVVTYAHSNPKIINPKKKSRYGQTLSPYDSDEDDDDDDDDDDDDWLLNDDFAEVTEYEKKKPKSHKQTIAKKSVKKGIVKPEESETDEDDLDLGISPNATSEKKKESWRLDGRGKMSSRKYVEKLYPRLAEEIDIDPKCVPLLDYLSTFGLKESHFVQMYERHMPSLQINVFSAQERLDYLLSVGVKHRDIKRMLLRQPQILQYTVENNLKAHISFLMGLGIPNSKIGQIVAATPSLFSYSVENSLRPTIRYLIEEVGIKETDVGKVVQLSPQILVQRLDITWNTRYMFLSKELGAPRDSVVKMVKKHPQLLHYSIDDGFLPRINFLRSIGMCNSDILKVLTSLTQVLSLSLEDNLKPKYMYLVNELNNEVHILTKYPMYLSLSLDQRIRPRHRFLVELKKVRKGPFPLSSLVPNDESFCQQWAGTSVDTYLAFRQRLLLKEFANKYDKRG
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MASLMGFLTVSKISEPPKASVAQEAFDYIYERIAAPAEVDVERFLEIGHFESLATATCLSLEDLSLYLFAFAVDESAKRIYKISEKHFVAWMAGLISKLPRNAAPPTRENAYAPLFAAAHDAIVDLNNTIRSNEEKRSKFYQFLYNWCLKGNDASDRVDSAKELWSCFFSASPVSLTVEEARRKFTAYVCFPRINQWLDFITMLGEKATESKSGRVAVEQSGVSFDTWTQLLLFARFDNYDAYDDEDSWPVTMDDFVVYVRKLEESKKV
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus.
Sequence:
MVSAWYYNETEEDQRALHKYEPSQDVSLDELAKLGVLHWTFDPETELDKVNELSKERCYFSRDEISISKETLPNYEEKLKIFFTEHIHEDEEIRYVLSGSGYFDIRNKDDRWIRIHTKKGDMIILPAGSYHRFTLDDTNFIKAMRLFKEDPKWTPINRSEKTDSNQHRLSYLETISGKRAADTDPECNLSGKKLKSLVGESVDVDPIHTQSEPAPGDTKEAEPTLKKAVIETVKSVDVVETPANIAVTEE
The following text describes a protein:
Function:
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
Subcellular Localization:
Cytoplasm.
Sequence:
MLILTRRVGETLMIGDLVTVTVLGVKGNQVRIGIDAPKDVAVHREEIYQRIQRGDEPVASGAHHNDDCSD
The following text describes a protein:
Function:
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MREAHPIERAVGMAYYASDSDGTGGRLRDSPADFRVRELEAFDTQPADAPTGDYPWLVVRATLHEWDTNDFARELANTVGMSRERVRWAGTKDRHAVTTQLFAVRDLDAAQVPEIRNADIEVVGRAGRGLEFGDLAGNAFEIVVRDPDAPERAAAVADELAAFGGGTVGTPNYFGQQRFGSKRPVTHEVGLAILRDDWEAAAMAYLGAPTEHEPADSQRAREYVAETRDWTGALAEFPQRLRYERTMLHELADGGSFRDAVETFPSNLQQLFVHAAQSYVFNRIVSERMARGLPFGEPVAGDVVWFADSDADAAVAQPDAARQQRVTDSRVDVMARHCERGRAFVTAPLVGTDTEFADGDPGEITRGVLDDLGLSRADFDLPGEFDSAGSRRAILLRPDLTVSHDPLAFEFALPSGSYATVVLREFLKPSPLAL
The following text describes a protein:
Function:
Catalytic component of the GATOR1 complex, a multiprotein complex that functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. In the presence of abundant amino acids, the GATOR1 complex is ubiquitinated and inhibited by GATOR2. Within the GATOR1 complex, NPRL2 constitutes the catalytic subunit that mediates the GTPase activator activity and under methionine-sufficient conditions, the GTPase activator activity is inhibited by PRMT1 through methylation and consequently inducing timely mTORC1 activation; Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.
Subcellular Localization:
Lysosome membrane. Note=Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent.
Domain:
The arginine finger is critical for the GTPase-activating mechanism.
Sequence:
MGSSCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSTEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHVQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKEGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVSRDERSHPARLYTGCHSYDEICCKTGMSYQELDERLENDPNIIICWK
The following text describes a protein:
Function:
May play a role in the control of androgen receptor (AR) protein steady-state levels.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEPQSWDLHVDERNNVVYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGEDRLLEKLPEAVGFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVLGPENNLIITGSRDALIQVWSLSEQGTLLNVLEGVGAPVSLLVRGGTLVVSASRKSSSFKVWDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEGEEQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAIAYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYENSCCRGVRCACFSRDDKHVFAGMEDRSVTAWSTVDGTLLAVQFVHAVINRIIPTSNGFMAPTSHGYLIRERFQCPSVRASQQDPLKNFKKAVWLVKTRQREELAAAEASQDAEPVAVEGKESKSNKRSQVCLIL
The following text describes a protein:
Function:
Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MAEFIEPVDKQKIINMLLSAYADEWIAAYYYTLTAYAIKGPLSEEVAEHFLEEAKEELEKHARLIADRLQDFDIDPPRDFTKLWEISGCKYPPIPNDPYDIDGWIAAAVKAEECAIRAYKELYQYTHGRDPVTEELAEEILRDEVKHRTDLINLLTKEGAKRL
The following text describes a protein:
Function:
Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.
Sequence:
MEKSYSCDRASELLQHFVTKYRHVLLGASAVGVFAIKLAPHVAPQWYYPTVYQLWDQDGPVQLPLHHGNLFQEVSGKFGLNDAGKFKVFPLYGFYDPFSAGLSWLPGGVVLGVPSYFLNASKEDVQNKQITVSGKLLNFASEEGKQFCNSLVFSDSALKFAIGRELSMVKSNAALYQATLPPVCLVGTYAGILYSKQLLGLFQIPFRFRVALNILGGTIGLVVYYLLSDTMEHYFDHKADKVCAKLGREYAQGGMEFYDKLLLRNQALRVLLGRKGQKMYTPYGNVRPKSMFFMKHPQLTDRRRKVAEIYHFDFA
The following text describes a protein:
Function:
Thiol-disulfide oxidoreductase that participates in various redox reactions in the chloroplast. Mediates the reduction of PSI-N in the thylakoid lumen. May interact and probably reduce other target proteins of the thylakoid membrane, such as FTSH2, FTSH8, LHCB5, atpA, atpB, atpE, petA and petC. Involved in the biogenesis of the plastid cytochrome b6f complex. Reducing equivalents are provided by stromal M-type thioredoxins and probably transduced through the thylakoid membrane by CCDA. Possesses low insulin disulfide bonds reducing activity.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MARLVFSLNLPSSHGFNLSPRNLQSFFVTQTGAPRFRAVRCKPNPESSETKQEKLVIDNGETSSASKEVESSSSVADSSSSSSSGFPESPNKDINRRVAAVTVIAALSLFVSTRLDFGISLKDLTASALPYEEALSNGKPTVVEFYADWCEVCRELAPDVYKIEQQYKDKVNFVMLNVDNTKWEQELDEFGVEGIPHFAFLDREGNEEGNVVGRLPRQYLVENVNALAAGKQSIPYARAVGQYSSSESRKVHQVTDPLSHG
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MEKPLLPRESGQFVAGRSRDVFVEGSGVQKVAEMLYHLRNSDDLSANGWKKANPLAPAPTSDQVANWVFVVDTMNFSFWPEKETQQCEVTYKSVTYTGYMTLCASITRAMEEGIPITDPMYFSQMSLKELAHVLRSDNETDMPMLQERHEALTEGGCVLLEHGGSFQSFINQAGNDAQKMVELIVEKIPSYRDEATYEGKRIAFYKRAQILVADYWAVMEAKGQTGIINMNWLTMFADYRVPQALVYLGVLRYSDSLMQTLKNGELLCSGDRREVEIRGCSIWCVELIKDRLSQLVQERDGQTCSINSAIIDFYLWPFAKQHHKEMAHIPIHHTRCIYY
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDDDAAAAVRSVWADNFEAESAVFRQIAPHATHVALNVQYPGCVVRGDAQKRHYDMTAEERYQVIHANVSLLKPLQVGLAVRTGDGGRFAWEFNLRGFDVASDLDARDPDSIAYLARRGVDLARLPGSGVHGHELRWMLRDSGLLGARASWATFASAFHVGYFAAMMSGEELPGDVNAFMEVVRQLLGPSVYDVKLLARQHDRRCVGALSHVVKQLGVAQPDEPNSTPAGTGSTLALLAFETLKEKLGADAENHRGQLCGLQAV
The following text describes a protein:
Function:
May be an activator protein for the gylABX operon.
Sequence:
MSETGDATPGGVREVKSAARTVELLEVLAARGDRPARLQELADELGVPRSSMYALLQTLISRGWVRTDVTGSLYGIGIHALLTGTSYLDSDPRVRAVRPYLDEASEALGETIHLGRLDGHDVAYLATRESHEYLRTISRVGRRLPAHVGALGKALLAERPDADLPEGPYEAFTPNTHTGREALAADLARTRERGYSVDREEGVAGIVGFGFALRYDVPALDAVSCSVPVARLTPDHEARIVAVMREIRAKLEATVPVGGGSIHWR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLKLRFGLFSLLSRSTLQKPIQNAFPRAIVAAFSTEASSVPIDEGVQVGKPKELNIRKFKPITPGLRHLRQLVNDHLWKKGPHRALTVTKRKTGGRNHTGKITMRHIGGGHKQRIRLVDFIRKKPGSQRVLRIEYDPGRSAHIALLEHFETKEKSYILACEDLRAGDVVESLTHLKKPASGDNIIQGLDNGQFFVEKVKRGNCLPLWAIPTGTAIYGISLEQGGKAKLCRSAGSYGRITSIYDDKYLVVKLQSGEERRVLQTASATIGRVSNINWQHRKLGKAGRSRWLGIRPTVRGMAMNACDHPHGGGGGKSIGNKPPQSPWGVLAKGFRTRKGRHKNKMIVKGRPRGKKNKR
The following text describes a protein:
Function:
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
Sequence:
MGLFESNLPKHIAVIMDGNGRWATSRGKSRSEGHREGAQAIDRLMDASLELGLKNISLYAFSTENWKRPVTEIRSIFSLLIEFIETRLDTIHKRGIRILHSGSRKKLTRGVLDKIDFAVDKTQKNKNLTVNFCLNYGSRDELLRAAQELFLERKRSKVALEKPLKEKEFEKFLYTSILPPVDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPEFDKNSLVDSLKWYETRTRKFGGLTNG
The following text describes a protein:
Function:
Required for ciliogenesis.
Subcellular Localization:
Cell projection, cilium. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MLKLSLKRFASVLFFQMLFLVVDLGINSFSYLARGHHSAVIFLFIAQDVCLMLSFTAFVFSLYSTYVYQAGMANLLYEKFRTPLLISMTYFFLSIALHLWQVLGHSNEPYQFQWPKALTALFIIHRLFSPIYYYLYKKSALKMSDPRFYENLDWIASQLSIK
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MTFVCAISGQAAETPVVSPSSGQIFEKRLIIKYIIENGTDPISNEKLSEDELVELKAAAPDAVPRSITATSIPSLLKMLQDEWDACMLNSFSLRQQLQLARQELSHSLYQHDAACRVIARLTKELTGAREALSTLKPHGSYAAGDTDVDMEKSVEEQGMSEAVAKKLDDKAKTLTTARKQRGKGVPEGLATVEDISAIKEVASHNAIHSTGTPGITALDVQGDLVLTGGADKTVALFNVATEHVVTSFKGHTKKINGVILHADGKTAVSCSSDSTVRVWSASEDKCRHVIDTHQASVTGISLHATGEFILSVSDDGHWAFSDINVGKTLCKVRGDESGQIGVSSAQFHPDGLIFGTGTADSVVKIWDLKQQANVANFPGHSGAVRAIAFSENGYYLASGAEDGEVKLWDLRKLKNLKTVAIRDGKFPVNDIFFDESGTYLGVAANDVSVIHVKPWTIVASFEESQSAVTGVRFGPNAMSIFSAGMDKTLRIYRK
The following text describes a protein:
Function:
The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
Subcellular Localization:
Nucleus.
Sequence:
MPNDNKTPNRSSTPKFTKKPVTPNDKIPEREEKSNEVKTPKIPLFTFAKSKNYSRPSTAIHTSPHQPSDVKPTSHKQLQQPKSSPLKKNNYNSFPHSNLEKISNSKLLSLLRSKTSAGRIESNNPSHDASRSLASFEQTAFSRHAQQQTSTFNSKPVRTIVPISTSQTNNSFLSGVKSLLSEEKIRDYSKEILGINLANEQPVLEKPLKKGSADIGASVISLTKDKSIRKDTVEEKKEEKLNIGKNFAHSDSLSVPKVSAGDSGISPEESKARSPGIAKPNAIQTEVYGINEESTNERLEINQEKPVKLDENSANSTVASALDTNGTSATTETLTSKKIVPSPKKVAIDQDKITLHDEKTLAPSKHQPITSEQKMKEDADLKRMEILKSPHLSKSPADRPQGRRNSRNFSTRDEETTKLAFLVEYEGQENNYNSTSRSTEKKNDMNTSAKNKNGENKKIGKRPPEIMSTEAHVNKVTEETTKQIQSVRIDGRKVLQKVQGESHIDSRNNTLNVTPSKRPQLGEIPNPMKKHKPNEGRTPNISNGTINIQKKLEPKEIVRDILHTKESSNEAKKTIQNPLNKSQNTALPSTHKVTQKKDIKIGTNDLFQVESAPKISSEIDRENVKSKDEPVSKAVESKSLLNLFSNVLKAPFIKSESKPFSSDALSKEKANFLETIASTEKPENKTDKVSLSQPVSASKHEYSDNFPVSLSQPSKKSFANHTEDEQIEKKKICRGRMNTIITHPGKMELVYVSDSDDSSSDNDSLTDLESLSSGESNEIKVTNDLDTSAEKDQIQAGKWFDPVLDWRKSDRELTKNILWRIADKTTYDKETITDLIEQGIPKHSYLSGNPLTSVTNDICSVENYETSSAFFYQQVHKKDRLQYLPLYAVSTFENTNNTEKNDVTNKNINIGKHSQEQNSSSAKPSQIPTVSSPLGFEETKLSTTPTKSNRRVSHSDTNSSKPKNTKENLSKSSWRQEWLANLKLISVSLVDEFPSELSDSDRQIINEKMQLLKDIFANNLKSAISNNFRESDIIILKGEIEDYPMSSEIKIYYNELQNKPDAKKARFWSFMKTQRFVSNMGFDIQKSCEPVSISTSVKPHVVEPEHMADAKIMPKDILQITKKPLMVKNVKPSSPPDVKSLVQLSTMETKTLPEKKQFDSIFNSNKAKIIPGNGKHASENISLSFSRPASYGYFSVGKRVPIVEDRRVKQLDDITDSNTTEILTSVDVLGTHSQTGTQQSNMYTSTQKTELEIDNKDSVTECSKDMKEDGLSFVDIVLSKAASALDEKEKQLAVANEIIRSLSDEVMRNEIRITSLQGDLTFTKKCLENARSQISEKDAKINKLMEKDFQVNKEIKPY
The following text describes a protein:
Function:
Has a role in pre-mRNA splicing and is essential for growth. Phosphorylates srp1.
Sequence:
MSDDRFAEDEIIQQRRKRRLEILKKYQQTGNGHSDLSIPEKKLKEDVDQVSTTKPIEAVPKMKTNASKIEINKEGSNSNTKLDVTNSTTSDSPSIKSSVQIEDTEDDMFADSPSPSVKRQNTGKGISTLTRSFADMQDNWDDIEGYYKVVLMEELDSRYIVQSNLGKGMFSTVVSALDRNRNQTFAIKIIRNNEVMYKEGLKEVSILERLQAADREGKQHIIHYERHFMHKNHLCMVFEMLSLNLRDILKKFGRNVGLSIKAVRLYAYQMFMALDLLKQCNVIHSDIKPDNMLVNEKRNILKICDLGSASDASENEITPYLVSRFYRAPEIILGFPYSCPIDTWSVGCSLYELYTGQILFPGRTNNQMLRYMMECKGKFSHKMLKRSQFLNDHFDADFNFIQIDHDPITNQETRKPVKFSKPTKDIRSRLKEVPTSTDEEFIIRQELMDLLEKCLELNPEKRVPPEVALKHPFFIKK
The following text describes a protein:
Function:
Inhibits TNFRSF1A, TNFRSF6/FAS and TNFRSF12 induced apoptosis. Directs the degradation of host NFKBIB but not NFKBIA. Also suppresses host NF-kappa-B activation by interacting with and preventing ubiquitination of host NEMO/IKBKG, the NF-kappa-B essential modulator subunit of the IKK complex. Interferes with host CASP8/caspase-8 recruitment and activation at the death-inducing signaling complex (DISC). May lead to higher virus production and contribute to virus persistence and oncogenicity. Also participates in the inhibition of host autophagy by interacting with host SH3BP4.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MSDSKEVPSLPFLRHLLEELDSHEDSLLLFLCHDAAPGCTTVTQALCSLSQQRKLTLAALVEMLYVLQRMDLLKSRFGLSKEGAEQLLGTSFLTRYRKLMVCVGEELDSSELRALRLFACNLNPSLSTALSESSRFVELVLALENVGLVSPSSVSVLADMLRTLRRLDLCQQLVEYEQQEQARYRYCYAASPSLPVRTLRRGHGASEHEQLCMPVQESSDSPELLRTPVQESSSDSPEQTT
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MGNCFGEPAEVEAKDSWLDEKTKIGAGAHLRDDYKVLGGSIGYGRVATVRQGVEKRTGRKVAIKACSKKVLSTRPARISKVSEIHALQKIFEGHAHTNKVVELYATYEDAIYFYIVMELCSGGDLFQNLATRDVFLEQDAAYIIQQLLLAIQHCHAHRVVHRDLKPENILFVNDHSFDIKLVDFGSAAIVDDSTVLRDFMATPFYAAPEVWERHYGPECDIWSIGAILYVLVGGLPPALTRQTAHKNPTWVDLQAGKVTGLPEHISPELRDLLTQLVEPDPEKRVTASAALQHRWIRGEGQQNARNLEGSIRNIRAYQKIRQFQKAAVVLLSVTVDSDQMTLLANKIRQLKGSSGDLTELELEALVADVGLKEQASQLVALRVRMLGTDESDAFLSFDAADFLEILECRQLAAQQRRSRGRKGSGRRAAQTLDRIDELSVAGPRISFDESGDGRAHMSRLGSKGRSWHHLDTLGSLERIADGDEVEDEQSSSPIMLSRAKTSSPLAKVLKAGGEKLSPKKRKQKLDRLVTVHGPGLYAALMRSGEADGMRTHSSKE
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MWQCRRLASTSAAATVTQKQRFRPVIGLEIHVQLNTLTKLFSRCPTSESSPNRRVDAFDMATPGILPALNRQCVLRALKMARILHCQVPKSSRFDRKHYFYADMPAGYQITQNEKPIAKNGKFGFWVFDERIEVPYWKEVEILQLQLEQDSGKTIHMTSQAAPPTSLIDYNRAGCALVEIVTSPCFTTAIEAIRFVQILRLLLIHHAICDGELHRGHIRVDANVSLAKDDVWGTRTEIKNMNSIRTIHTAINYEIARQFEILKNGGAVQNETRAADSEGRTVSMRDKETEETDYRFMVEPNLPQLKIHGKWLKEVEEELKCEGKADFEVLREDVGFDARSAVHIAEEPELLSFVKRCIRYKAPTVTPVDILYWMKELKTVMQRSKANYPPQSEFFARQFTTLLKFSSEHRLTRLRLLDLLRHYATDDDVMAGELEILIEENRYWRIRAPAEIDEIVRKSMEKQEKLVEKCRSGHVKSFNRLRNSIIDSSNKCIELEDLEASIRRLL