lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in the rescue of stalled ribosomes by promoting ubiquitination and degradation of proteins on stalled ribosomes. Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their degradation.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
Sequence:
MLEVEVESDNKHLVADELIALQSIYPEIHLDGNNYGRLNIPVNTESDYFLSFKSPDESTLTDTIVVRHFPDLVMEFFLPEAYPFNSPPTFFLKSSWLPLKQKRVLTSSLIKLWNEIHDCVLFDAIEHVRSIATIAFHLPTEMVFPGGFDDLKKEILAFDKNAKLLEFQIRKFQCNVCFDEFNGTDCFQLTRCGHVSCQSCLRDYYTMCIQEGMFSQIKCIDLDCGKDAPVLTLKELESIVGVQLTNRYKELEEKRRYENDSNIIFCPRSFCQGPSKRDPGQKLAICQKCDFAFCSFCQATWHGDLSPCKLEGDSKKLVEMYLNYQENEPEKALELEKRYGKRIIDRLVEQVKNDEEAEKWVLLNGQRCPTCDRVVERIDGCCHMNCLCGTHFCFLCGAYLMEQNPYKHFNDPVSSCYGMLFASAAEKQRFSENWT
The following text describes a protein:
Function:
E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to CDC48 and elongates mono- and diubiquitinated ERAD substrates presented by the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to RAD23 and DSK2, which target them to the proteasome. Has E3 ubiquitin-protein ligase activity, accepting ubiquitin from its cognate E2 ubiquitin-conjugating enzyme UBC4. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. Promotes ubiquitin chain elongation at 'Lys-48' on the DOA10 substrate PEX29. Also involved in the proteolytic processing of the ER-bound transcription factor SPT23.
Miscellaneous:
MISCELLANEOUS: Present with 2600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The U-box domain is required for the ubiquitin protein ligase activity.
Sequence:
MTAIEDILQITTDPSDTRGYSLLKSEEVPQGSTLGVDFIDTLLLYQLTENEKLDKPFEYLNDCFRRNQQQKRITKNKPNAESLHSTFQEIDRLVIGYGVVALQIENFCMNGAFINYITGIVSNVNSYTDFLSQIIQRAILEGTALDLLNAVFPTLLEYCNKHVSHFDLNESVIYNNVLTIFELFVTFKPIAEIFTKIDGFFADYSCKPQDFERKTILGPILSLSPIEAAVAIRNYGDNLLRSKQQTAMIHESLQAEHKVVIDRLFFIVDKLVRGSLNSRTDMISYFAHIANKNHLRRADHPPFKELSSNGFMSNITLLLVRFSQPFLDISYKKIDKIDANYFNNPSLFIDLSGETRLNSDFKEADAFYDKNRKTADSKPNFISDCFFLTLTYLHYGLGGTLSFEEKMGSEIKALKEEIEKVKKIAANHDVFARFITAQLSKMEKALKTTESLRFALQGFFAHRSLQLEVFDFICGASTFLIRVVDPEHEFPFKQIKLPLIPDQIGVENVDNADFLRAHAPVPFKYYPEFVVEGPVNYSLYISKYQTSPIFRNPRLGSFVEFTTMVLRCPELVSNPHLKGKLVQLLSVGAMPLTDNSPGFMMDIFEHDELVNKNLLYALLDFYVIVEKTGSSSQFYDKFNSRYSISIILEELYYKIPSYKNQLIWQSQNNADFFVRFVARMLNDLTFLLDEGLSNLAEVHNIQNELDNRARGAPPTREEEDKELQTRLASASRQAKSSCGLADKSMKLFEIYSKDIPAAFVTPEIVYRLASMLNYNLESLVGPKCGELKVKDPQSYSFNPKDLLKALTTVYINLSEQSEFISAVAKDERSFNRNLFVRAVDILGRKTGLASPEFIEKLLNFANKAEEQRKADEEEDLEYGDVPDEFLDPLMYTIMKDPVILPASKMNIDRSTIKAHLLSDSTDPFNRMPLKLEDVTPNEELRQKILCFKKQKKEEAKHKASE
The following text describes a protein:
Function:
Involved in sperm flagellum axonemal organization and function (By similarity). May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).
Subcellular Localization:
Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSHAVTIQEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPLFIVSSEKDHTQANIQATLIRSRLRKVPRFKTMFSNLIHYPRYSLYWSKSDPVPPFISRQWKGHEEKHREALRQLAITDTSFQMPREVYEDPEVTGKNRYKYFERPFLPFFQQMPFNVVYAISKAEPYTFPPTSTKQLSIPSKLTVGTQTDYRDADVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEATLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQEAKEAKMATIQRTHVSTIRKLVGKGKNIEGKLERRNITKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESRLPDFVTQPRIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEARKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEIEMAVIYLQKLLRGRVIQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRIREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSCTESMVQKRLTEGQQDEASNAAMLLEKEIQNENNS
The following text describes a protein:
Function:
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MTKKRKRQDDFQKVKLKVGKKKPKLQNATPTNFKTKTIHLPEQLKEDGTLPTNNRKLNIKDLLSQMHHYNAGVKQSALLGLKDLLSQYPFIIDAHLSNILSEVTAVFTDKDANVRLAAVQLLQFLAPKIRAEQISPFFPLVSAHLSSAMTHITEGIQEDSLKVLDILLEQYPALITGRSSILLKNFVELISHQQLSKGLINRDRSQSWILSVNPNRRLTSQQWRLKVLVRLSKFLQALADGSSRLRESEGLQEQKENPHATSNSIFINWKEHANDQQHIQVYENGGSQPNVSSQFRLRYLVGGLSGVDEGLSSTENLKGFIEIIIPLLIECWVEAVPPQLATPVGNGIEREPLQVMQQVLNIISLLWKLSKQQDETHKLESWLRKNYLIDFKHHFMSRFPYVLKEITKHKRKEPNKSIKHCTVLSNNIDHLLLNLTLSDIMVSLANASTLQKDCSWIEMIRKFVTETLEDGSRLNSKQLNRLLGVSWRLMQIQPNREDTETLIKAVYTLYQQRGLILPVRTLLLKFFSKIYQTEELRSCRFRYRSKVLSRWLAGLPLQLAHLGSRNPELSTQLIDIIHTAAARANKELLKSLQATALRIYDPQEGAVVVLPADSQQRLVQLVYFLPSLPADLLSRLSRCCIMGRLSSSLAAMLIGILHMRSSFSGWKYSAKDWLMSDVDYFSFLFSTLTGFSKEELTWLQSLRGVPHVIQTQLSPVLLYLTDLDQFLHHWDVTEAVFHSLLVIPARSQNFDILQSAISKHLVGLTVIPDSTAGCVFGVICKLLDHTCVVSETLLPFLASCCYSLLYFLLTIEKGEAEHLRKRDKLWGVCVSILALLPRVLRLMLQSLRVNRVGPEELPVVGQLLRLLLQHAPLRTHMLTNAILVQQIIKNITTLKSGSVQEQWLTDLHYCFNVYITGHPQGPSALATVY
The following text describes a protein:
Function:
Accepts electrons from ETF and reduces ubiquinone.
Sequence:
MKASSKSMKFLTARLAFYPPQMNNKGNYIASLSKVRWWLAKQAEALGVEIYSGFAGAKLLHSDDGKAVQGVITNDISLDRSRKPKDPEWSSMLTGSCWPRAAMTAKTPRPTRDGKDPQTYGLRIKEVWRVKDDVYEPGKVLHTLGWLLQRDTYGGSWIYHLEDNMVWLLVWIIQTHTCLLIRNFNLEDELGKTGNGSDLKAGLITGLGLFAWKQFNWTFGELVVRKFCNPGNLDLAKEMVH
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSFCLNLLKVIVKAIDNKKGRNPVVLDVQNISQLTDYFVFVEGNVGVHIKAIADTIIEELKKLKVYPLNVEGLSHSDWVVIDYGFIVIHLFVSSVREQYCLEELWKDGAIITSDCLAS
The following text describes a protein:
Function:
Stimulates the release of gastrin and other gastrointestinal hormones.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle lumen.
Sequence:
SENTGAIGKVFPRGNHWAVGHLM
The following text describes a protein:
Function:
Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). Can also catalyze the reverse reaction.
Sequence:
MNNYTIKDITRASGGFAMLAVDQREAMRLMFAAAGAKTPVADSVLTDFKVNAAKILSPYASAVLLDQQFCYRQAVEQNAVAKSCAMIVAADDFIPGNGIPVDNVVLDKKINAQAVKRDGAKALKLLVLWRSDEDAQQRLNMVKEFNELCHSNGLLSIIEPVVRPPRCGDKFDREQAIIDAAKELGDSGADLYKVEMPLYGKGARSDLLTASQRLNGHINMPWVILSSGVDEKLFPRAVRVAMEAGASGFLAGRAVWSSVIGLPDTELMLRDVSAPKLQRLGEIVDEMMAKRR
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MADDEPVDQKNYLEERCKPQCVKPLYEYERCVKRVENDESGQKHCTGQFFDYWSCVDKCVAPKLFEQLK
The following text describes a protein:
Function:
Component of nuclear pore complex.
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MAAAVGPLGDGELWQSWLPNHVVFLRLREGVRNQSPAEAEKPAASTSPSCPSLPPHLPTRNLVFGLGGELFLWDAEGSAFLVVRLRGPSGGGVEPPLSQYQRLLCINPPLFEIHQVLLSPTQHHVALIGSKGLMALELPQRWGKDSEFEGGKATVNCSTIPIAERFFTSSTSLTLKHAAWYPSEMLDPHIVLLTSDNVIRIYSLREPQTPTKVIVLSEAEEESLILNKGRAYTASLGETAVAFDFGPLVTVSKNIFEQKDRDVVAYPLYILYENGETFLTYVSLLHSPGNIGKLLGPLPMHPAAEDNYGYDACAILCLPCVPNILVIATESGMLYHCVVLEGEEEDDQTLEKSWDPRADFIPSLYVFECVELELALKLASGEDDPFASDFSCPIKLHRDPKCPSRYHCSHEAGVHSVGLTWIHKLHKFLGSDEEDKDSLQELTAEQKCFVEHILCTKPLPCRQPAPIRGFWIVPDILGPTMICITSTYECLIRPLLSTVHPASPPLLCTQEDAEVAESPLRILAETPDSFEKHIKRILQRSAANPAFLKNCSARSSEKDLAPPPEECLQLISRATQVFREQYILKQDLAKEEIQRRVKLLCDQKRKQLEDLNYCREERVSHLFRKSLREMAERLADKYEEAKEKQEDIMNRMKKVLHSFHAQLPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQRKMEKVLSPQKPTITLSAYQRKCIQSILKEEGEHIREMVKQINDIRNHVTF
The following text describes a protein:
Function:
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes the second common step in the parallel biosynthesis of isoleucine and valine. Converts alpha-aceto-alpha-hydroxybutyrate (AHB) to alpha,beta-dihydroxy-beta-methylvalerate (DHMV) and alpha-acetolactate (AL) to alpha,beta-dihydroxy-isovalerate (DHV) in isoleucine and valine biosynthesis, respectively.
Miscellaneous:
MISCELLANEOUS: Present with 883000 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRTQAARLICNSRVITAKRTFALATRAAAYSRPAARFVKPMITTRGLKQINFGGTVETVYERADWPREKLLDYFKNDTFALIGYGSQGYGQGLNLRDNGLNVIIGVRKDGASWKAAIEDGWVPGKNLFTVEDAIKRGSYVMNLLSDAAQSETWPAIKPLLTKGKTLYFSHGFSPVFKDLTHVEPPKDLDVILVAPKGSGRTVRSLFKEGRGINSSYAVWNDVTGKAHEKAQALAVAIGSGYVYQTTFEREVNSDLYGERGCLMGGIHGMFLAQYDVLRENGHSPSEAFNETVEEATQSLYPLIGKYGMDYMYDACSTTARRGALDWYPIFKNALKPVFQDLYESTKNGTETKRSLEFNSQPDYREKLEKELDTIRNMEIWKVGKEVRKLRPENQ
The following text describes a protein:
Function:
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRPKLKKASKRMSCHKRYKIQKKVREHKRKVRKEAKKRGHKKRKTDPGIPNSAPFKEALLREAEQRKQQLEELKQKQKLERQKEQAKKKLEAQNVSPPKEEPVKKEPVKPKEQPSNQPDNRNLKESFCRELKKVIEESDVVLEVLDARDPLGCRCSQVEQLIIQSGGNKKLLLVLNKTDLVPKENLRKWLWYLQKEFPTVIFKSSVQPKDKVNPSRKKQRDSKAGPINLSIGRVCVGGEGLLKLLQNFCETDNETLHVGVIGFPSVGKSSIINSLKKTSACQVGPARGITRSMQVVRVDKQIKMLDSPCLIASPSNSAAALALRSLINTGDEKSVLELMSAVLKHCSKKQIMLHYKIPDYRNSLEFLILLAQKRGMHKKGNVPDSPGIARVLLSEWTGAKLNYHSKPPRSFNFSPHLNEDIVAAMQQGFNRDQLAQYNANSIKAIHSPSKNSSIVFESSGLINGIIDENHISEEESEDDDDTSMEEEDQDSADEDIEVSFEPAQKPEKAKALLERPRSGEQLGAQREDSLNLDLLPEQDDAYDFNTDYV
The following text describes a protein:
Function:
Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation.
Miscellaneous:
MISCELLANEOUS: Present with 7600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRKRSTKPKPAAKIALKKENDQFLEALKLYEGKQYKKSLKLLDAILKKDGSHVDSLALKGLDLYSVGEKDDAASYVANAIRKIEGASASPICCHVLGIYMRNTKEYKESIKWFTAALNNGSTNKQIYRDLATLQSQIGDFKNALVSRKKYWEAFLGYRANWTSLAVAQDVNGERQQAINTLSQFEKLAEGKISDSEKYEHSECLMYKNDIMYKAASDNQDKLQNVLKHLNDIEPCVFDKFGLLERKATIYMKLGQLKDASIVYRTLIKRNPDNFKYYKLLEVSLGIQGDNKLKKALYGKLEQFYPRCEPPKFIPLTFLQDKEELSKKLREYVLPQLERGVPATFSNVKPLYQRRKSKVSPLLEKIVLDYLSGLDPTQDPIPFIWTNYYLSQHFLFLKDFPKAQEYIDAALDHTPTLVEFYILKARILKHLGLMDTAAGILEEGRQLDLQDRFINCKTVKYFLRANNIDKAVEVASLFTKNDDSVNGIKDLHLVEASWFIVEQAEAYYRLYLDRKKKLDDLASLKKEVESDKSEQIANDIKENQWLVRKYKGLALKRFNAIPKFYKQFEDDQLDFHSYCMRKGTPRAYLEMLEWGKALYTKPMYVRAMKEASKLYFQMHDDRLKRKSDSLDENSDEIQNNGQNSSSQKKKAKKEAAAMNKRKETEAKSVAAYPSDQDNDVFGEKLIETSTPMEDFATEFYNNYSMQVREDERDYILDFEFNYRIGKLALCFASLNKFAKRFGTTSGLFGSMAIVLLHATRNDTPFDPILKKVVTKSLEKEYSENFPLNEISNNSFDWLNFYQEKFGKNDINGLLFLYRYRDDVPIGSSNLKEMIISSLSPLEPHSQNEILQYYL
The following text describes a protein:
Function:
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MRFTYNQYKHYESGYRIPSKMHNLSHNNNNNSNNNNNGGGHTNNNNNGNNSGHHYAHHNNSNNGGNNNTNFQAYQHHYKSNFGMRMTMSTNSTMSARIHRKGFRIPSKRQPGKGLPGKLHTITRTGPGKMVPGKRIPQRPHPPPCDNSNDSGLGFDQHTELRSSAGAGGVTDPAANGGSGSNSGQRSSLLVNSALTNTVAAAAAAAAAAVASNTLQQHQQHHQQQQQQQQQQQQQQQQQQQQQQQQQHSPQQHLIRAIPVSRFISARNVTRVANKRQPTTPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDKVAVLQVFIGTDIGRVAPHMFYQACKVAGKNSTQCNEKKVDGTMVIEIDFKPETDMTITCDCVGILKERNVDVEHRFPEHLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPIICTQPPGVPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVVFQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIVSSGKKSEPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASNASGSSGWSAAGGSGNNTSTGDNVEAKHEIDSGMMPPPITTQIPMGVRRSSLPSVTPMITDQQLVHLNAVAASAEALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKPSLDTIMYDQSNSLPGFPTVVAPATAAAVAAAVDIDPTAVAVAVELAVKNEIVKHVVQQHQQMQEQMHEQQQQQQQQQQQQQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALFTTSAVIDHALTDILQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPAAALAGAAALGGPAPVDVTGGLSTDIIMNPAVSPSTILCSANGAATAVVPNILAPHQVTMANSILNDIAMQPEPTQQDAAVAALALSNIMMSPPTAASGVGVGDTLPPTPATMQPEVAATATSTAVSNMIIKAAADFITTQEQEQHHYHHHGRIHSHSPQAAVGVSGNPAETASDPLVDLLLNHSNTPETAAAAAAAVAVEAANFQSMNHSHHSHHGHHGHSHGHGHSRVTGHVSGHVTSHHRGHHLPVVPPTPQESLIVALASENALQKSVATAAVTTNGAVMTQQASAPNTAGSILPAAVGAVAAAAAVAVQPPIPQELTTMSDQDLISYINPSTFDQL
The following text describes a protein:
Function:
Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
Subcellular Localization:
Dynein axonemal particle. Nucleus matrix.
Sequence:
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTSPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
The following text describes a protein:
Function:
May be involved in thiaminediphosphate transport across the mitochondrial membrane.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MNRVGIDVDHMIGVLLLAVVVVFWVGASCLTNELLETNAYNKPFFLTYLNISSFALYLTPDLWRIIQSRRKSLQERTERTLPIHTQESFSEFLPLLSSTPSTSSNLSSIADTKVKDTMRLSLLFCVLWFVANLAANAALSYTTVASSTILSSTSSFFTLFLATSLGIETFSTKKLLGLFVSLFGIILIVMQSSKQQDSVSASSFLVGNTLALLGSLGYSVYTTLLKYEISSKGLRLDIQMFLGYVGIFTFLLFWPILIILDITHMETFELPSNFHISFLVMLNCIIIFVSDYFWCKALILTSPLVVTVALTFTIPLAMFADFVWREAFFTPWYIIGVIFIFVSFFLVNHRGESAVEKDCAAVEKGPILDA
The following text describes a protein:
Function:
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Subcellular Localization:
Nucleus speckle. Chromosome.
Sequence:
MCWKVEIVVYCKRQKPQTRGTQYVPGERNKLNEDHGRRQSSSLANGMDNSHPICSSGEKRSHHWRSYKLIIDPALKKGSHKVYRYDGHQFSTPSFGMSPVDIVRDPRIGRLWTKYKETDLPVPKFKIDECYVGRVPPKEVTFAKLNDNVREGFLTDMCKKFGDIEEVEILYNPKNKKHLGIAKVVFETVKAAKDAVQNLHNTSVMGNIIHVELDPKGENRQRYFQRLINGSYTPLTLPVGGEEACDVSPRSLAEALMACEPSRRLFEGGSSVVAGTTPSGTNTPMSLDTAYSSLRQDTPQSQGTPHTPRPSGTPFSQDSSYSSRQGTPAFQANRAESSGGYKSRRHETKFQDAYNRRPERRYVHGPTQRGNTEQPPSFKQHQPPEPPSPAFTHTPPPPTSANFKTAYSQYQPPIPQEYTVASYHQPVQRELDYRRPPQAPPPPSTDFLPVRDRPTTPPIPEPPPAPETQPTTPPSSTPEPCPSPTQESERNSLDSRIEMLLKPFLNERGDSDAEVRMDGSPISSSSSQLSPIPPQRPSRPSSTGLEDISPTPLPDSEDDEPIRGTASLLANSRGMSPTNMHSKSCVGEPRTAIDKMDTGHQSSGEDMEISDDEMPGTPIASGDCDKNIVVNSALSLIQTIPMPPPGFPPLPHAAGFPLPPHHLPHHSTVSHLPSHHPMLHPLHSYGMMHFLPVDLLSSLPQLLQMPFQMQTQMLSRMAQSQHPYAYPYPAPSANPAAMPFGGPYPPLSVVSAPADTLHGQPWPLPSMPQFNPAVPPPGYEPQKEDPHKATIDGVLMAIVKELKAIMKKDLNRKMVEVVAFRKFDEWWDKQELSAKATLTPVKTGEGKDEEKERAKPKETMSSHLPWNKGEGLGFEGMGLGIGLRGIRLPSFKVKRKQPPEPTSTSDNKRVRPSTPVDDELEDEESERMGRTDGSRVDPAGSSSKRRPARPLELDSEGEEEEETSGKEESSLSDHEEEPVDDASERLSSGKDLEEEDEKKSESHSSESESSDSSDDEASSSSSSKSGSDSSGSESSSDYESSSEEEEEEEEEEERIVGMDDEEDVDARTSTSSSTTSTSSSDEEEVVEVKAPSTPTGPPPEEEPNELGRLEAVDEAEIDHKPSMVSLIKTKVEEVRPPSPKGLPADELDVDLEVKIPVPKTEASLEEVGNLRPPTPTGSFADSDQDTRPKIPTEDFPRTPGHEGPVPLESETTVPRSLPTPSMHLPLPPSHVPDPQSLLPPPETLPDMPVRGRLPTEEDIPRTPGRDLMDRARGLGKLQSTDTVPVTPGSDTPLTGNSLSSPHILGSPFSYPAQSPVLSAGIPRTPGRDLTFAPAFPDSAGLSAGLPIHRKASSEILEEKPLFKEPLLSASPQASLPNNAASSPFPGPPLPTASLPEPALPPQGSPPASIENSFPASPKELPVPMIDVPVPLDDTPSKKKLVRSKNKKGIQDSEEPQVTLIEASSLPELPVNNQYPDLPSESIKEEDGEPAFSEKEESQVPTIIPKVEETSFYVEEPIQKTRRQRRGWQELLLSMHSPVASPRRPSFMPRSDFEEMTILYDIWNDGIDEEDIRYLKITYDKMLQQDNAHDWLNDTLWVHHPPTNMGSATGVKKKRKEDGIRDHVTGCARSEGYYKIDKKDKMKYLNSSRLQSEEPDVDTQGKSIPAQPQVSTRAGSERRSEQRRLLSSFSCDSDLLKFNQLKFRKKKIRFCRSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSRQPINVNEEITYDYKFPIEDEKIPCLCGAENCRGTLN
The following text describes a protein:
Function:
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Sequence:
MSRLQADISRRNPQDDYDLIQRVGSGTYGDVFKARNLHSNEFAAIKVVKLEAGDDFSIIQQEISMMKNCKHKNIVAYFGSYYRRDKLWICMEFCSGGSVQDIYNLTGSLQELQIAFITRETLRGLHYLHTNGKMHRDIKGANILLTDVGCVKLADFGVAAQITATISKRKSFIGTPYWMAPEVAAVERKGGYDQLCDIWAVGITCIEFAELQPPMFDLHPMRALFIMSKSGFKPPTLHDKNKWSQNFHNFVKFALTKNPKRRPTADKLLEHPFVNREMSEQITRDLMDKAYNNISHAAPIAYPDCNDIDEDEVQSLFFLFQSNNVNSPLQTPTTTTTNYTSQQQQQMYNRDIQNFFIGEPNQNYLLLTTTTTTITSSSSSATTPTTARTTTPTTTTAAATKFATSPTSESESNHAMNNKSSFSPSSTPNAKTMEDESSFSSSSSSSLTSPSPLSSPSPSSSPPYSSSSSSPSSSLPSSSSSSSSQKPMCNGLPPTPKVHMGACFSKVFNGCPLHINCTTSWVHPYTKDQHILIGSNTGIYTLNLNEIHENSMELLHARSCVWMCVVKDVLMSISGKTPALYRHDLLNLHGRGTHRFSMSTINMIPERLMPKKFAITTRVPDTKGCLKCCVGRNNDAYQYLCVAMPHAVLLMQWFDPLNKFMLLKQFDYPSMSDLKIFEMFTIPDQQYPILCVGVKKSREKKNHVQFELINLNSSSNWFIGPECGKENIQVTGVTQLDKDTFVISYDNLVQMTNLLGVPKLSVIVFDFYIQSTVVLQDSVLAFHRHGMQGRSFKTNEITQDVFEPTKVFRLLGCDKVIVLESLSTENPDELANLYVVAGHENTF
The following text describes a protein:
Function:
May be involved in spermatogenesis.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus inner membrane. Note=Colocalizes with the NPC and nuclear lamins at the nuclear periphery.
Sequence:
MGNLLSKFRPGCRRRPLPGPGRGAPAPLSRDASPPGRAHSVPTPRPFRGLFRRNARRRPSAASIFVAPKRPCPLPRAAAAPLGVLPAVGWGLAIRKTPMLPARNPPRFGHPSSVRIPPPSRMFTLLLPSPREPAVKARKPIPATLLEETEVWAQEGPRRVKKDEDPVQIEGEDDEKRTPLSSGEASSTSRSQGTQGDVASFRCSPGPLEGNVYHKFSENSMSEKAQASPASSCLEGPAMPSTHSQAGCARHLGKPDPDATAPPEPAVGCSLLQQKLAAEVLNEEPPPSSLGLPIPLMSGKRMPDEKPFCIPPRSAAPPRAARNRPCKRKMSIPLLLPLPPSLPLLWDRGELPPPAKLPCLSVEGDLHTLEKSPEYKRNSRILEDKTETMTNSSITQPAPSFSQPVQTTDSLPLTTYTSQVSAPLPIPDLADLATGPLILPIPPLSTTPKMDEKIAFTIPNSPLALPADLVPILGDQSNEKGGSYNSVVGAAPLTSDPPTPPSSTPSFKPPVTRESPISMCVDSPPPLSFLTLLPVPSTGTSVITSKPMNSTSVISTVTTNASAHLTSQTAVDPEVVNMDTTAPSQVVIFTSSLSSRVSSLPNSQIHCSAEQRHPGKTSVYTSPLPFIFHNTTPSFNQLFGKEATPQPKFEAPDGQPQKASLPSACVFLSLPIIPPPDTSTLVNSASTASSSKPPIETNAMHTTPPSKAVILQSASVSKKYLPFYLGLPGSGNTQPSGNTASVQGSTSLPAQSVRAPATASNHPLNPGATPQPKFGAPDGPQQKTSLPSAHDFLSLPIMVPPDTSTLVSSASAASLSKPAIDTSDMNTTPPSKTVILQSTFVSRKEEYIRFYMGLPGSGNTLHSDSIASAQVSTSFPAQADRRPTTTSSHPLNTGSISHSTLGATDGQQKSDSSFILGNPATPAPVIGLTSPSVQPLSGSIIPPGFAELTSPYTALGTPVNAEPVEGHNASAFPNGTAKTSGFRIATGMPGTGDSTLLVGNTIPGPQVIMGPGTPMDGGSIGFSMSAPGPSSTSGELNIGQGQSGTPSTTSVFPFGQAAWDPTGHSMAAAPQGASNIPVFGYTSAAAYIPGLDPPTQNSCSGMGGDGTRSIVGGPCVPAFQQCILQHTWTERKFYTSSTHYYGQETYVRRHVCFQLP
The following text describes a protein:
Function:
Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. Can complement the fission yeast mcm2 mutant.
Subcellular Localization:
Nucleus.
Sequence:
MDDSENNAPSTPGSPGFSTDRLPPNTTTSRGATDPSSYSDDDDDDVVGAEEAEVDPNVLPEDDGVVAAEEEEDGEDLFNDNYLDDYRRMDEQDQYESVGLDDSIEDERNLDEIMADRRAAEAELDARDVRTGAAPDRKLPRMLHDQDTDEDMSFRRPKRHRANFRPPREPRTPRSDDDGDGATPSSPGRSQRGMYSGGDVPMTDQTDDDPYEDEFDEEDEMNMYRVQGTLREWVTRDEVRRFIAKKFKEFLLTYVNPKNEQGEFEYVRLINEMVLANKCSLEIDYKQFIYIHPNIAIWLADAPQSVLEVMEEVAKNVVFDLHKNYRNIHQKIYVRITNLPVYDQIRNIRQIHLNTMIRIGGVVTRRSGVFPQLQQVKFDCSKCGTVLGPFFQNSYTEVKVGSCPECQSKGPFTINVEQTIYRNYQKLTLQESPGIVPAGRLPRYKEVILLNDLIDCARPGEEIEVTGIYTNNFDLSLNTKNGFPVFATVVEANYVAKKQDLFSAYKLTDEDKAEIEKLAKDPRIGERIVKSIAPSIYGHEDIKTAIALAMFGGQEKNVKGKHRLRGDINVLLLGDPGTAKSQFLKYVEKTGHRAVYTTGKGASAVGLTAAVHKDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGGRYDSSKTFTQNVELTDPIISRFDVLCVVKDIVDPFTDEMLARFVVDSHARSQPKGANLEDRVPTDVEDDPLAAARQADPDILSQDMLKKYITYAKLNVFPKIHDADLDKISHVYAELRRESSHGQGVPIAVRHIESIIRMSEAHARMHLRSYVSQEDVDMAIRVLLDSFISTQKFGVQKALQKNFRKYMTYKKDYNELLLLLLRTLVKDVLHFEEIVSGPTTRLTHIEVKVEDLKNKAQEYEIYDLRPFFSSAHFRDNNFVLDEGRGIIRHPLAA
The following text describes a protein:
Function:
Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Domain:
The serine protease 1 and 2 domains are catalytically active, whereas the serine protease 3 domain lacks the essential Ser residue of the catalytic triad at position 1015 and is predicted to be inactive.
Sequence:
MEPTAPDLQLVPEVTKAVSVSAPDPGPCRTAVIAVVGISMAIVTLGVLSAFFSAQGAHVEHIAELHGIRFTSSLQQENSDFYRLLTHALQTLLHFLLRALQPLSLKQEADILQKGIQARLQEQGLSLAAYGTIVSVELTGRCEGPVTERDLKSGHCPGNVFSCQNGQCVSKENPECDDRVDCSDESDEAQCDCGWQPAWRSAGRIVGGVEAAPGEFPWQVSLRENHEHFCGATIIGARWLVSAAHCFNEFQDPAQWAAQAGSVHLSGSEASAVRTRVLRIAKHPAYDADTADFDVAVLELARPLPFGRYVQPACLPAATHVFPPGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYTRVTRLRDWILEVTSAADMPVVPTATPAPATPSTPWPTSPESWAPNTFAKPTAAPSPVPLHPSTTAKPQECGARPAMDKPTRIVGGISAVSGEVPWQASLKEGPRHFCGATVVGDRWLLSAAHCFNHTKVEQVQAHLGTVSLLGVGGSPVKLGLRRVALHPRYNPGILDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFYLAGIVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDPSSMARPHTSSTRLIPSEPPKTTAAGLIIPEATTSRLATPRATIRVTTRPLNTTLSARSTTTRGQTAAPSAPGTTIHSHLPDCGLAPPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDIYGDPMQWAAFLGTPFLSSTEGQLERVARIYRHPFYNIYTLDYDVALLELAGPVRRSRLVRPICLPGPARPPDGARCVITGWGSLREGGSMARQLQKAAVRVLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSWGYGCGRPHFPGVYTRVAAVLGWIGQNIQE
The following text describes a protein:
Function:
Highly specific to D- and L-alanine and does not catalyze the racemization of other amino acids.
Sequence:
QPAFSVVTRPTFYKLLKAGRDIGYDGTYTTSEDEWIANFTTGWSDQLSRRLSTRLPRLYTRNGKIVRICPSLEYLFLEASEPFTSRGITRHVAATTGCVQDLGTDLDFIRPGGAITGLCS