lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). Both pathways seem to involve interactions with G-proteins (Probable). Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. During early embryonic cell divisions, directs the asymmetric positioning of transcription factors such as pop-1 and dsh-2 in daughter cells in order to determine cell fate specification. Acts redundantly with other Wnt receptors such as lin-17 to control vulval precursor cell specification and also the polarity of different cell types including distal tip cells, seam cells, AVG interneurons and P-cells and their descendants. Plays a role in the migration of cell types including distal tip cells and the QR neuroblast descendants, QR.p and QR.pa during larval development. Negatively regulates the unc-6/Netrin receptors unc-5 and unc-40 to control distal tip cell polarity and migration. Acts through ced-5/DOCK180 and ced-10/Rac to control both distal tip cell migration and the phagocytic clearance of apoptotic cell corpses. Furthermore, it is also required for the migration and axon guidance of the different neuronal cell types including CAN, ALM, HSN and the two mechanosensory neurons AVM and PVM. Mediates Wnt receptor cfz-2 in directing ALM migration, but may also act redundantly with the Wnt receptors cfz-2 and mig-1 to direct the migration of other neuronal cell types including CAN and HSN. Mediates Wnt ligand egl-20 in the control of the anterior-posterior axon guidance of AVM and PVM neurons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Uniformaly localized along the cell membrane throughout the cell cycle, but occasionally enriched at prophase towards the posterior pole of the cell. Sequestered from the cell membrane to endosomes by plr-1 to prevent Wnt signaling.
Domain:
The FZ domain is involved in binding with Wnt ligands.
Sequence:
MHRHILILFLFGCLSADQRLSSTSISSMNGFSTTRKCEHITIPMCKNLDYNQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTVLEKPIQPCRELCLSAKNGCESLMKKFGFQWPDQLDCNKFPVTDLCVGKNSSESSNSKNYRSSNDVTFGVSTIANEVVLSPKKCPHHMHTTSGSHFSLPLLSGRLPECSLTCEADNQVPMMFDGRVRRILRIWTAAWSVACFVCSLFTLVTFLVDLSRFAYPVRPILYLAFCYLAISTVYMIGVVGEDGFACGTYGSTPTTLVTQGGENVGCSALAVVHYFFFMSSCAWWLVLCLAWFLAANLKWGAESIAALSPYFHAMCWGVPAVLSVTVLVTNSVDGDVFTGICSVGNLNPSALVYFFFTPIVVSLALGAVLLVCGIWSMIRIRSYIKLQHADVERNISKLEKLMLRIGAFAIMYSLPTAMNAAIMWYQAVNMPAWLEGWLHHRCVRLQDRELFGFTYPVDDCPMDPKVAAPEIIVFLLKYVSQLVVGITCAIWVVSSKTLSSYHKAYLALSSRSPTVPAHVDQVNMR
The following text describes a protein:
Function:
Involved in spliceosome maturation and the first step of pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MAGSLRDRAHKPSTRPRAFDDSDDDDAGLLASSSSRHEEEIVSFGRDGAKGRGASPVSDAPRVIPVTSNLDWRQDRKERLGRASNLQALGPLVSMRRAGASAVPGLASSSSTNDDINIDAINTEAQKRGLKLRSSKVTRADDTPQQLSGDVFDEQTADASAVPKASADVAGEDAEAIKALLAGQGNDSAGTGGQLIIHQETESELLQHDIDSRPEAPTLDDYAATPIDQFGMALLRGMGWKEGMGAGKGGKGPQQAAEPRKRAALLGLGAKERPTGPLNLSKPSSSSGNLQPKDKRDYKYVPVSKSDPRDYSNGRSPSSDHQPREKRPSKSHSTDLPSSHDSRRGDRDDRHARHSRTSHRQRSRSPTRSGVHDRDRRHERRRDGRDPERRSHPSSRSDRDRRSECDRDERRSSGHRR
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MELVVQSRETDKKSVIKKIRQQGGIPAVLYSGGKSLANIVVDARVFSKFLSTLESGALASTVFTLSYEGREIKALVKDIQYHVTTYDVIHLDFEELVDGRDVRLNIPIRCINTVDCVGVKLGGSLRQVIRCIRVVCKPKDIVPFLELDVQSLGLSQTLKLSDICIPEGIRPVTSLKEVAVTVARR
The following text describes a protein:
Function:
Receptor for the neuropeptides RYamide-1 and RYamide-2. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. RYamide signaling may suppress feeding behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEHHNSHLLPGGSEKMYYIAHQQPMLRNEDDNYQEGYFIRPDPASLIYNTTALPADDEGSNYGYGSTTTLSGLQFETYNITVMMNFSCDDYDLLSEDMWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAGVWFIALATALPIPIVSGLDIPMSPWHTKCEKYICREMWPSRTQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVGDRMNATSGTGPALPLNRMNTSTTYISARRKPRATSLRANPLSCGETSPLR
The following text describes a protein:
Function:
H2A.Z-specific chromatin binding protein which plays an important role in the neural crest cell differentiation and/or migration during early development and is essential for the development of the head and eye. Acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAAVAGAPGPGEGGESEQDSETIPGERRLGRLSCEPMEAELDSERRSLVRCEPCCGMEIDTQENAGPDIEQLGDSGAEQVYGIHTNSEFVSVSAVDYMGINQGQIAPENRKARSEQLPREPFLQRQPIPMILSEVTDSGIYTGLCLEEAKFSSNNGSEASLNYSECDNRSVGTTEGSVVTSGIDSLIPGSEVQVTLDHIIQDALVVSFCHGNRIFSGVLMDLSKRFGPHGIPVTVHPRREYKNKPVESIQEESKSFHEEPLVKSEENSPEDVTPIQQLENCKVQNLWTTKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKKKIYREEPTSIMNAIKLRPRQVLCDKCKNNVVADKKEIRKVATDSYKTEEGKRRRHETVTTVNKKLKTDHKVNGKSQNESQKRTPITKVTNLAHGRGKVVKVPSQTSAAKTQMHTKEVLQNKNMDHVKAREVLKMAKEKAQKKQKVTTSSKNAHSKVHFTRRLQNSSSGTLPPRLRIKPQRYRNEENDSSLKPGLETLRSSKIGIKPQTRYSATRSAGETPSEIQSPSNGPEEISSEMQDTNVCVPPEEQDLQQTLGKRGSKSNITVYMTINQKKANSSSASVCSSDSTDDMKSSHSECSSTENFDFPPGSMHAPSSSSSSSASSKEEKKLSNSLKIKMFSKNVSKCVTPDGRTICVGDIVWAKIYGFPWWPARILAITVSRKDTGLLVRQEARISWFGSPTTSFLALSQLTPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET
The following text describes a protein:
Function:
Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MDFSFSFMQGIMGNTIQQPPQLIDSANNRQDDANSSDQADEGGGTPYDSGLQTDFQYPTPTTEDLPHLTNGYQPSLGYEPQGKYQTYSQFPNGSSNGYGTRNYTALEYYHLETAALRPIEGMSKASPPEPTSPPNLLQAPPSSTTTPQKKTGSPEIKLRITKTIQNGREMFESSLCGDLLHEFQASEMTRKKHERRKERREKRKKTRHHHHHHHHHREEVKAEEQQPPKIKKLEPPPEEERVQKHLPVSPLSPEVRTGVWFHVGDLVWSKVGTFPWWPCMVSCDPQLHVHSKINTRGAREYHVQFFSSEPERAWVHEKRMKEYRGEQQYEQLVAEDSARACNLSEKLKMKKPRPQRERVQWEIGIAHAEKALRMTREERIEQYTFIYVDEEKTPETKKPVNVGKKSRRSTSSSEPDSNRLSDVLPSPPRQPLPPSPIPYNNRDSPSENRRQSQRKPLHEEEHPPQLPPAKLPWKTAAARKSIPASVLLHRGTLDLQKCNMSPVVKIENVLALQNATSEGFEQFIYTTKEVGNKTEITVKAPEKAFAPSPNQKSEKSSAQHTPAPETSGATGPSEKKHQRRSNRTRSESEKSLDSMPKKKVKKEQAEDIPLTAVQTGLQKGASEISDACKPLKKRSRASTDVELANSSYRDASDSDSRGLNDAQISFEKQPDSPSAAADADASDVQSVDSSISQRSSKRDSVCQICESFGESLVSCDGECSRLFHLECLGMDTLPDGKFICMECKTGLHTCFSCKIPSTSVKRCSAPCCGKFYHETCARQYSGTIFDSKGFRCPHHCCSSCTADKDPYRASKGRMLRCIRCPVAYHNGDSCIAAGSLHLSSSLVICSNHSKRSGHASSAVNVGFCFVCARGLIVQDYSLVSSMSIKSHFLLTDSKRAELMKIPMIPSSSPAYIKKSEKGGGKLLCCDSCPAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFADGQTSINKTFKKALEEAARRFLELKAQRESKEALEIEQNSRKPPTYKHIKSNKPVGKVQIQLADVSEIPRCNCRPTDDTPCGLDSECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPETEIFFTERRGWGLRTKRDIRKGDFVNEYVGELIDEEECRMRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYNLDCLGNGRRECHCGSDNCSGFLGVRPKTACATAAEERSKNARLKAKKRKLKTEQKQIHEDFCFRCGDGGELVMCDKRDCPKAYHLLCLNLTQPPYGKWDCPWHQCDICGAASSSFCDFCPASFCREHEKASLTSSALDGRLCCSDHDPRRPLASGLRNKIRCKTESDDSLSPPQF
The following text describes a protein:
Function:
Could possibly oxidize fatty acids using specific components.
Sequence:
MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEIALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKFQGA
The following text describes a protein:
Function:
Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates. May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Subcellular Localization:
Melanosome. Membrane; Lipid-anchor.
Sequence:
MACGPGTVRPGPVPTPRGPCWAGILRLRLLRGLNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEETVSALHECKTLFILRGLPGSGKSTLARVILDRYRDGTKLVSADSYKITPGARGAFSEEYKRLDEDLAAYCRRDTRVLVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTSWRLDCTLLKEKNQWQLSADELKKLKPGLEKDFLPLYFGWFLTKKSSESLRKAGQAFLEELGNHKAFKKELRQFVPGDEPREKIELLTYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQDAVKKAYGKAFMLTISALFVTPKTTGARVELSEQELLLWPNDVDKLSPSDSLPRGSRAHITLGCAADVEAVQTGIDLLEIVRQEKGGNRGEEVGELNRGKLYSLGSGRWMLNLAKKMEVRAIFTGYYGKGKPVPIQGSRKGGAFQSCTII
The following text describes a protein:
Function:
Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex. Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein.
Sequence:
MAAGERCAAAAAGMKEDFEIIDKTQVPDTAELKNVEKEKEEAKWSAPILSLAKKASENLALSYGSALKSAASVGLISKAVSNDSTAKTTARHHAMEERANLMNMMKLSIKTLIQSALSLGRTLDSDFPPLQQFFVVLEHCLKHGLKAKKTFIGQNKSFFGPLELVEKLCPEASDIATSVKNLPELKTAVGRGRAWLYLALMQKKLADYLKVLLDHKHLLSEFYEPDALMMEEEGAVIVGLLVGLNVIDANLCLKGEDLDSQVGVIDFSLYLKETQDSDGKQEVSSQSVISCFTIRDGDITAVLDQKHYVEELNRHLSCTVTDLQNKIDCLEKTNSKLQEELAAATDRIGSLQEEQQQLKQQNELIRERSEKSVEVTKEDTKVELDTYRQSRQGLDEMYSDVWKQLKEEKKIRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKSQNAECSLQQKTEAISSFEGKTNEMMSAMKQMEERLQHAEKARQAAEERCNKMKQELASRLDTCRQQMSQLDSKCSTLEKELKSEKEQRQTLQRELHREKDATSLLKTELEQMEGLKKELRKLQDEKQQLEKVCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKGHTWLKDDEATHCKQCEKEFSISRRKHHCRNCGDIFCNACSSNELALPSYPKPVRVCDTCHTLLLQRCSSNSS
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEETSDSESQDIQEHNETVRALSAGLLQIYEPKLREVKENLKELINKQNDLQIAMTSEKNAFSSRQIQEVNEMVLKTKAYKDKVARIKMQMHQIHQRTKNLRAKALEIQELKVNQCATKLQQLHYEESLVANSKRTPRKS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPPKGASTAKVPMRLPPLPKLRVRRPNQTDSNPCLAIMTSVLTCWASSGYNVAGCQALETQLRTCMDAPKAAAQKKNTINYHLSRMYPKIVGPRKKK
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWQAYTDNLIANGKVDKAALYSRAGDALWAQSGSFELQQPEITEIAKGFDSAEGLQTSGLHVQGQKYFLLRADDRSIYGKHEAEGVICVRTKQTILIAHYPSGVQPGEATTLVEKLADYLINVGY
The following text describes a protein:
Function:
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
Sequence:
MKRLLIIDGHAFVFRAYYAFGASNLTNSKTGKPSGATFGFFKMLFKLIQDYTPSHIAMTFDPGGTLERGKIFQDYKANRKPMPEDLRPQIQEVMDTLEKIGFKILKVEGQEADDVIGTLCETYRSTAKEILIFSGDKDLYQLLEKKNIKMLRGKKGVTEFVEIDSAWVKEELGVDVKQIPDYMGIVGDTSDNIPGVKGIGDKGASKLLQEYKSLDGVYKNLEKIKNPGLKTKLSEQKENAYLSKQLATIRRDLQLGITEKDIEIPDYKSDAAILYFKSQGYNVLSKDLAKSAGKEVPKDPEPAADSSENVTIPTAEKGSYKLISSIDELSKICRGLLKSRVLSVDTETTSPNPAMAELVGISFSNQEKTGFYVSVKNNASLFQDKSLNLDEVREHLGPVLSSQVPKVGQNIKYDLIVLENHGFVLNNIQFDTMLASYVLRPEGRRHNMDDLAKEFLNYNTITYEDLVGTGKKKKELTDIDPEQVAEYAAEDADVTFRLYQIFRKSIKDSGVEPILREMEMPLISVLAKMEKTGIALDVPYFEELARDFDREIRHLESEIHRQAGGPFNIASTKELQKILFDNLKLRIVKKTQTGFSTDHEVLEELVGEHPIIEKLLDYRKYTKLKSTYVDALPKMVNPKTGRIHTSYNQTIAATGRLSSTDPNLQNIPIRDREGRLLRKGFTVDSNDYEILSLDYSQIELRIMAHISKDPAMLEAYNHGLDIHKRTAAALYGVPETDVTHEMRDKAKVVNFSVIYGVTPYGLSRNLRIPRDEAKSFIERYMTQYPGVKSYMDSMVEFAEKNGYVQTLTGRRRPVTDINSTHKSAKEAAKRIAINSPIQGTSADMIKIAMIKIHEDIEKKHYKSRMLLQVHDELVFEVHKKEKDDFKASMKKHMETAMSLDLPIVVEGKFGVNWDEAH
The following text describes a protein:
Function:
May function as molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MQSIVKKDLDLPTLRNESSNVKGLSHPVESIQLDQGKTEIKLKNFAMKNVFGTHMVMNNEIEKQIYSQFKRLPTLQSSMVGLETILGLDEDFDFGDYLCDPATSEAPLPQLHTSMEHRLGMTSSKSIL
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.
Subcellular Localization:
Cytoplasm.
Sequence:
MSASETPAGEFPPEQEPGHVVVVGAGIAGLAAAHRLLEAGARVTVLEASGRVGGKLLPGEIAGVRVDLGAESMLARRPEAVGLARAAGLADRLQPPSTATASLWTRGALRPMPKGHVMGVPGTAAALSGVLSEEGLARIERDAELPRTEVGDDVAVGEYVAARLGREVVDRLVEPLLGGVYAGDAYRISLRSAVPQLFEAARTHTSLTEAVRALQGRTATSPPSGPVFMGIEGGIGTLPPAVADSVRARGGEIVTQAPVTELRRTASDGWRIVAGDRVLHAGAVVVAVPAGPAAELLRAEAPAAAAELSAVEYASMALVTLAYRRSEAAALPEGSGFLVPPVDGHTIKASTFASRKWGWIADEDPDLVVLRTSVGRYGDTEILGRDDAGLVAVSRHDLAEATGLTAAPVATRVTRWQDGLPQYPVGHHARVARVREHVAKLPGLAVCGAAYDGVGIPASIASAYAAADQIRGDLGGVEELTAHPVQSLHGGAGE
The following text describes a protein:
Function:
Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The OPR/PB1 domain mediates the association with NCF4/p40-PHOX.
Sequence:
MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKREEWKKAEEHLALAVSMKSEPRHSKIDRAMESVWKQKLYEPVVIPVGRLFRPNEKQVAQLVKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLSPGQKGKEEPKQEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTVNEQWLEGECKGKVGIFPKAFVEQHPTTDLESTPGRV
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRSSVLQGRHILSSSARPRPAPQWLARAGASSRLAGQRFFADAKSPTPVTPSSATPVPAETAAKSTAGPSATETPTPAPTRKTGRFRKFLIYLILTSGLAYGGGVFLALKSDNFHDFFTEYVPYGEESVLYFEERDFYRRFPNTLRNKNRLSPASRDEGSRVTIPSKSGLSSKEVEETGTDVSQPGPHMSAVTPAKADEATIKPAAAKPEEKTAAVKEAKKQAQEPEKPREEPKQEPKLPGSAPITTLEFANVSEGDEPIVQELVKTFNDIITVISADEDSAKYSKPVAKAKEELQKIGEQILSVRDEARRAAQEEIEKAHATFDESARELIRRFEEVRANDAAQYREEFEAERERLALAYQQKIQTELQRAQEIAEQRLQNELVEQAIELNRKYIHEVKDLVEREREGRLSKLSELTSSVSELETLVTGWREVIDTNLKTQQLQVAVDAVRSALERSTVPRPFVRELVAVKELAGDDPVVEAAIASINPAAYQRGIPSTSQIIERFRRVADEVRKASLLPEDAGIASHAASLVLSKVMFKKDAEAGSDDVESVLLRTENLLEQGNLDDAAREMNSLKGWAKILSKDWLADVRRVLEVKQALEVIETEARLQCLRVE
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
AAMHLEEMEKKDAEFVQPVKKPRIETGNGKKAKRIKSAKEFFGAPSAKCSIEGADMGVLERWLMELGIGWVLHLADGVAAGKLKLDPNHASSWIRALTEITNTFCLMVSLLPGHVSEEEEDAAAAAAMESEYISSLQDLSIIQQAMLKMLAFVDFIDKLHALLRVRHTLSKALSEIRLLFDDPSPSARVVERIRSEIGSVLLAKEGKAADAIRSQVEEVSARIMESLEDDQDSSGTHKVTPSVLSYIRFLRTNYRTLDAVVCEYVPQIGDLSPLDSMSLVESNCVLYLSKSYEVTLTRKLERYMESYIQVSWAPVRNYSPLPYKFQSEFLKTYNTQKLWKVPDPELRKTLPRAITEKIVSGYTEYIEDNKITTLKFTPRDLEEMLQELFQG
The following text describes a protein:
Function:
Part of the gluconate utilization system Gnt-I; high-affinity intake of gluconate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPLVIVAIGVILLLLLMIRFKMNGFIALVLVALAVGLMQGMPLDKVIGSIKAGVGGTLGSLALIMGFGAMLGKMLADCGGAQRIATTLIAKFGKKHIQWAVVLTGFTVGFALFYEVGFVLMLPLVFTIAASANIPLLYVGVPMAAALSVTHGFLPPHPGPTAIATIFNADMGKTLLYGTILAIPTVILAGPVYARVLKGIDKPIPEGLYSAKTFSEEEMPSFGVSVWTSLVPVVLMAMRAIAEMILPKGHAFLPVAEFLGDPVMATLIAVLIAMFTFGLNRGRSMDQINDTLVSSIKIIAMMLLIIGGGGAFKQVLVDSGVDKYIASMMHETNISPLLMAWSIAAVLRIALGSATVAAITAGGIAAPLIATTGVSPELMVIAVGSGSVIFSHVNDPGFWLFKEYFNLTIGETIKSWSMLETIISVCGLVGCLLLNMVI
The following text describes a protein:
Function:
Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E.
Subcellular Localization:
Cytoplasm.
Sequence:
MGENADGDQVMENLLQLRCHFTWKLLFENNDIPDLEVRISEQVQFLDIKNPLGMHNLLAYVRHLKGQQDEALQSLKEAEALIQSEQLSKRSLATWGNCAWLHYHRGSLAEAQIYLDKVEKVCKEFSSPFRYRLECAEMDCEEGWALLKCGGGNYKQAMACFAKALKVEPENPEYNTGYAVVAYRQDLDDNFISLEPLRKAVRLNPEDPYLKVLLALKLQDLGEHVEAEAHIEEALSSTSCQSYVIRYAAKYFRRKHRVDKALHLLNRALQASPSSGYLHYQKGLCYKQQISQLRTSRNRQPRRQDNVQELAQQAIHEFQETLKLRPTFEMAYVCMAEVQAEIHQYEEAERNFQKALNNKTLVAHIEQDIHLRYGRFLQFHKQSEDKAITLYLKGLKVEEKSFAWRKLLTALEKVAERRVCQNVHLVESTSLLGLVYKLKGQEKNALFYYEKALRLTGEMNPAF
The following text describes a protein:
Function:
Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2/SPO72 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2/SPO72 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MIPQWIPQNIQKRLLLYVLQQLSLFSEIDLPNLEEVSLNNIILKDVALDPEKVGKLPGCNLRYGQIGSLELTTISGISGVNIDVNDAEIVISPDFDIDENMTNQVAFSLAQSTANLANTIMLNTNDGSDMNETSDPASEDDDEDDIDDKITKPIPPKRRTSSVTGNKTTALGGVMQKAVEIALSRLSIKVNSLKIKIVSDLTDLQMEVDSVSINSTNGTRTVSIKGVKLRTLKPNVNPGEGFQSGHAPQKKQQGSDNDSPTDANKHGSENDNDDDDDDYGNESLMDSMVFSHEEASSIYMSATSRSFEKSAASGIPGEVDNKATDKEDYSEDPPIIFYMDDCTIEFDGLSTISNLEIEVGNINLAFTPLTPTLVSIFQGVAKSLKIKYYQQKKKTKSRSAQRNEKFPQYTNDNDEIPEDQSESDDASHEPFFNRFKVNSFVISATSALSENGLFANKNGINIIFFNINIKQKNELLLYGGVETFKIIRFEDDNTYEIFHFDKPQSAPSSAPSYSGSNDVAGTSSSLSSSTGSATSKADIRFEVFKKSEESDDLEVTVLMAKSAHFNFDLQSLLILSNFAKAVSSIYDEYGLLKSVIDKLDTRDKKWSGGTNNSKMSSKSEFILQTATIFVNFIISDDCQLQLIVFPIKFNLRQEQLTISKILLNCTNGDTQVEGVIILTDVSLITKNQEFRAYFQSTNTTTSANTHPLPRKTTMNSKLSVIVQKFSSNVSMDRLKFIGEKLKNFSNEFIERSPTQSNSLENSFLNEPVERQRLESSLHMNSSLFSTRRPGRRLGLGFNNSPSVFLGSTRVTMASFQVCFKEATFNITGVFPKFGNFSVQMSDISFYKLKNDILGHILSVSVQRKKGDLVENLIHQYQDLSPNSLEFPLLSIKCKLGDKTTKIEITARNLVLEYYTNWLLLMDKEESIIDAVEEEIIEKVTPSQHSSSQNKLDIRYSMYDCMVGLTPGRLSCKSYLIIGKGDSDISFGVDQFYVKCSFRNISMVLIDDTKNILPFSEPSTSSSSSSSSATRQTPYVYIQPLDYYSKLGYIHLGLINVAHVGITFNTDIEALKDRNEKLGIKDSLTFVDLKTNLDECQFNLCADTANTLIQLVNDLKLPLNFKDEDKMKVDFADGINVMQGIDQNIFKGLTETLTELNLNGTENGSTSESSSQEASSLMFEEGHFDRGNRSLYDNSHVDPLHININLSKVKIYLHDGYDWKDTRKAIRGAVKNFETAQTAKTVAKEKEKKRKVEFETRDIEVQEDVFQETLFQSIHVVAPRNQNARDMATSINLDLQNDKDGESRDVSTANSGKSYKNLKLRRSAKHKLLFDLKSIEVGVNVYSTRDPRRDKTDENMKYELLNFIELRVGTVDIYDNVSTSTWNKFLSYMNILGDREIGTSMVKVSILNVRPDPAMVSGEAIMNVSVLPLRLHIDQDALDFLVRFFEFKDERFELPPDEMVYIQKFEISSIKLKLDYKPKKVDYAGLRSGKAGEFANFFTLDGSTLTLPKVKLFGIPGAPKIGIGLGRAWLPVFQSTQVIGIISGVSPLRSVVNIGGGFKDLVAIPISEYKKDGRLWRSIQKGTVSFAKTTGYEILNLGVKLASGTQVLLEQGEEMLGGEGSSVRSPNLGGSDNRRNSNASDELPVEVAKPKSQNNLLVSSQILNKASTKIETHSYDTKKLYSNIELDDEDMDDNRINGINKELLSKSIFLLAPAEEKLAKLQPHTKGNHEGLTEEEEDEDEDEEYQLYAYENEEELQEKLVSLYSNQPETIEQGLKSAYKSLGTNFKLTKKQLLKLRRELAETDTIQDSMVTVLKNSPIILMRPLIGSTEAVSKLLMGVGNQIDGKKLVEKKDKYPT
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MQWPPPWRRSPLVSATPPPGPTRGLLCPRRVSEAGDSSTEGARTGHRHYVTPAESAMEGRSQPLPSLRPASPTNAPAHGRGSDCTAKEPPLANVCRQNYGAAQDPVEPAGRRSASHVTGSSLGKAEVACGRRWRWAELLADTSWSPAGRATEMKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK