lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCKVEVIAWELKSYFLPDTAHFKKCTMSERGIKWACEYCTYENWPSAIKCTMCRAQRPSGTIITEDPFKSGSSDVGRDWDPSSTEGGSSPLICPDSSARPRVKSSYSMENANKWSCHMCTYLNWPRAIRCTQCLSQRRTRSPTESPQSSGSGSRPVAFSVDPCEEYNDRNKLNTRTQHWTCSVCTYENWAKAKRCVVCDHPRPNNIEAIELAETEEASSIINEQDRARWRGSCSSGNSQRRSPPATKRDSEVKMDFQRIELAGAVGSKEELEVDFKKLKQIKNRMKKTDWLFLNACVGVVEGDLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQDMLAVLLTEVSQQAAKCIPAMVCPELTEQIRREIAASLHQRKGDFACYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINWSLELATRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKALHDSLHDCSHWFYTRWKDWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVAMENDGYGNRGAGANLNTDDDVTITFLPLVDSERKLLHVHFLSAQELGNEEQQEKLLREWLDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEKWLDRYRQIRPCTSLSDGEEDEDDEDE
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity).
Sequence:
MDYLEKLQSLMENHPSDFFSLWEEYCFNDVVKGDELVVLLEKIKGSTIAPAFGKIAESVIPLWEQLPEGEEKDKVLSLVFDVQTTNSKNLLEIALQQVKKYEDSANYKEALRIVGLRDGITFSHCLGRFALLMHLSEGNFVFHQGGWGVGEIMGVSFLQQKVLVEFEGVLTAKDISFETAFRMLVPLRKDHFLARRFGDPDAFEAFARKEPVAAIECLLKDLGPKNAKEIRNELVELVIPEEDWSRWWQSAKIKMKKDARILAPASSKDPYVFDPKGFSFVSQLQASLSGSNDANKKITSCYAFVRDLGSELKDESNRQLVIKELKALDLPADSALLIQRAMLLSEFLGEKAPELECENIAKLSEDQLFDIVNNIEILSLQKSFLALIHSCSPVWVPVYTKLFLTTSTSMLREQVFKVLNADKEARENILKKVFAMIEQPLLCPELFVWLFARVVDGEDGLFAESDKKEIERQMLASALELMHKVATTSQKDLGKKLYSFLVGQRFLVVRQIIDQASIEYLKEFVLLSSKCPQFTQGDLGVLRSLAEVVQPALKRGTPEEEENILWTTSDSFTRMKNKLQSLVGKEMVENAKEIEDARALGDLRENSEYKIALERRARLQEEIHVLSEEINRAKILTKDAVFTDSVGVGCKVVLESDQGDKVCYTILGPWDANPDEKILSLKSKLAQEMVGKAVGETVLFQGKKHKIKEISSIWD
The following text describes a protein:
Function:
Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLALKTPGVLPGFKLSLGLTVLCLSLLVVLPFAMMAAKAAEIGWGGFWNTIAEPNVLAAVWLSLRMSFYAMLTNVVFGTLVAWVLVRYEFPGKGLANALVDLPFALPTAVTGIALATLYAPNGWIGRFFEPLGIKIAFTPVGIWIALVVVSLPFIVRAVQPVLEELSGEYEEAAATLGASRWTTFRRVLLPEITPALLTGAGMMFARATGEYGSVIFIAGNIPMVSEILPLIITGKLEQFDVQGASAVALFMLLVSFVILFALNVMQWALGRRSGAKG
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSFPLWLWLALGGAVGAVCRQAAVLLLAPLVARTGFPAAVLLINVLGSFLLGLTLALTGRGVWPEAVRMTFGTGVLGAFTTFSTFSTELDGLLLRGQGGLALAYAALSVGLGLTAAVAGRVLGARL
The following text describes a protein:
Function:
Toxic component of a type I toxin-antitoxin (TA) system; if it expressed it could be neutralized by antisense antitoxin RNA SokE.
Miscellaneous:
MISCELLANEOUS: Interrupted by an IS186 element, which silences the locus in strain K12 MG1655.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MLTKYALAAVIVLCLTVLGFTLLVGDSLCEFTVKERNIEFKAVLAYEPKK
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MSLFSNNMFLYLKFDVGWASNSIMARGLRPQLHPCEAQILQGTRVPRGMCTLRIVLPGWQRDPSGTMSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLEWKNIPKSFTRGTVIVPTLDSVLYDNQEFPDPEKFKPEHFLDESGKFKYSDYFKPFSAGKRVCAGEGLARMELFLLLSAILQHFNLKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPRS
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRRQVRNEYGLGTPELYKAANKDDPKAILDGVAVSGLVGILRQLGDLAEFAGEVFHGLQEQVMATASRSHKIMVRVQHIEAALPPLEKSVMTQKSHIHFAYTTGLDWHANIQTEQNHLLNSDLPQFILDSYEECRDPPRLHLLDKFDAGGPGACLKRYSDPSYFKRAMANSELMNADKSQKDKKARKSKKKGSRRRNGEFPHTELISRRNGRTQFAPSNIYGKSSAANVISNFNMRSTSELGDQSFDLRTRSDYAECVSNGSPSMQTNEHKHSALSSSKLRMQSNDVHSSVVDEQDGVSDDDFLHVSVQGRSAPNSSSVMWYEKTEIVEPTGQPHDHIVDDQHEASELRPMNFDLNKLAKRSVSLENHDADGVSSGDENIIDGNRPDASFGNVDTGLFGIDTQDAGSVGNQLDEIGSEPDNYVDALNTMESETDTDIECQTKREVELPTSSSKNTEMEYGAGLLCEMTNQSSDSYDVDSHTASYCPPNKQLDKNFADMAPKKDMTCVQTPHIYTISSNAKVSEDTESCENINFVNVSRVNDFEVANDQFSLSSNIPNSQAPSSHKIMDSSKSKESQAEVSGGPSIQFWTNGGLLGLEPSKPPDFSISNIPSQNPICPTEDESHDLAINTVRHTSQMGGSFSKLDTLIKTPEHREKDPSSVGENYVSPNASSPTDLHPNQVAGVGNKYQKTDSSECLRSFHDDDTVKRKDSSELATKTECAVMTTGVESPGSSEVKAPTDETGKEKVKNASGVFSLGNRLLVNGFQRKESSVHGDTSKPAPSSKTDAVNFSEPPSHEQKKGQQGVTHPISPKGITKEKHHSGFPANSLPPSPPLEHMKISFHPTNGFETSKLRLKFPDGCHSNENIRDVIFASFHLLPEPDIPRRDTCSDSDNDTFCRSSPYMSEDLSPRSESNSEQWESGETRGSIDHKLCDALHRVSSAESISSSSQLGGASHGNIYPDCELKNLDTEDAMRPFHSGPSLDFPSFDAVSPPTNKQELRSGSEQKDLPESRSHNSQEPTPPPPPFPPVRCVINCHLDVVEAKEGPSSEAIVHPKNLDIVQSTTSQPLSAPPKPPSVKEATACPPNKKQGQQKLNGRKEVNQDGHVKEVDERDDLLHQIRTKSFNLRRTTPKKPNFSSGPTTNVKVAAILEKANAIRQAVGSDEEGDDDSWSDDD
The following text describes a protein:
Function:
Plays a role in the flagellum-specific transport system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MFSRWNRWGRSVRLVLILLVMSCPLLASATPAALPAMAQAAAPAAAPAAPATGNQIPTLPNVSVGRIGDQPVSLPLQTLLLMTAITLLPSMLLVLTAFTRITIVLGLLRQALGTGQTPSNQVLLGLAMFLTALVMMPVWQKMWGAGLQPYLNNQIDFSTAWTLTTQPLRAFMLAQIRETDLMTFAGMAGDGKYAGPDAVPFPVLVASFVTSELKTAFEIGFLIFIPFVIIDLVVASVLMSMGMMMLSPMLISAPFKILLFILVDGWVLVVGTLAASFNAS
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAKPSSASSSSSSTTKDAQDLLRALWSAYSATPSNLKIIDLYVAFAVFSALLQVVYMALVGTFPFNSFLSGVLSCVGTAVLAVCLRIQVNKENKEFKDLAPERAFADFVLCNVVLHLVIMNFLG
The following text describes a protein:
Function:
Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis. Stimulates adipogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAHSSEEPFPFHGLLPKKETGAASHLSRFPEYDGRGVLIAILDTGVDPGAPGMQVTTEGKPKIVDIIDTTGSGDVNMTTVAEAKDGTITGLSGRILKIPPAWVNPTGKFRIGVKNGYEFFPKALKERIQKERKEKIWDPAHRAALAEVCRKLDEFELSHPTPSQSEKLQKEELQSQSELLASLEKKYSDPGPVYDCVLWHDGVTWKAVVDTSECGELSQCTVLSSYKENQEYASLGTVEMLNYSINIYDEGSTLCIVTSGGAHGTHVASIAAGYFPEEPERNGVAPGAQILALKIGDTRLSTMETGTGLIRAMIEVINYKCDLVNYSYGEATHWPNSGRICEVITEAVQKHNVIFVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVTPDMMVAEYSLREKLPPNQYTWSSRGPSTDGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGVIALVLSGLKQIGIRTCVPAVRRALENSALKVEDIEVFAQGHGIIQVDRALDYLTQNASLPTSQLGFTVSVGSQRGIYLRDPSQVLAPSDHSVGIEPIFPENTENSERISLQLHLALTCTAPWVQCPSHLELMNQCRHVNVRVDPLGLREGVHYAEVCGYDTAAPGCGPLFRVPITVIIPVKVTNSRNQEVSFTDVHFRPGQIRRHFITVPQGASWAEITLTSHSGDVSSKFVLHAVHLVKQKAYRANEFYKFSSLLERGSLTEAFPVLSGRVVELCIARWWASLGDVTVDYSISFHGLCVSPLPLHIHASEGVASFDVSSPLRYEEVSPSITLKSWVQPLRPLSSKIKALGMRDVLPNNRQLYEIVLTYNFHQPKSGEVTPSCPMLCELLYESEFDSQLWMLFDQNKRLLGSGDAYPHQYALKLEKGDYSVRLQVRHEQSNELERLKDLPFVVSHRLSTTLSLDIYETHRAALMGKKKANSVTLCPGTTHPFYITGLPDDKIPKGTSPGCYILGSLIVPKSEYGKKAGQASAKRQGKFKKDIIPVIYHLIPAPNKTKNGGKEKEKDKEGDKEKDVKEEFAEAMRDLKIQWMTKLDSSSVYDELVELYPDYLPLHVQRLHQLDNEKERVKHLGEVVSAADVVISHIDQTVLAVYLSLKTDPRPDAASIKTDMEKQKSSLLDALCRKGCALADQLLLPSATQDGAGAVYAGQTPATEAVEQVASSCDDVLQNVATALTDVFWEVQKWAELTDTKVLSFSYKHALVSKMYGRALKYASKMVEEKPSKENMRNCIQLMHQLGWTHCSAFSENWLPVMYPADYTPF
The following text describes a protein:
Function:
May play a role in a brassinosteroid-dependent regulation of growth and development.
Subcellular Localization:
Secreted. Secreted, extracellular space. Secreted, extracellular space, apoplast.
Sequence:
MAYNYRFAILLVLLSATVGFTAAALKPPVRTLNGNITLNLIWYGKFTPIQRSIIVDFIRSISSVTAAKGPSVASWWKTTEKYKTGVSTLVVGKQLLLENYPLGKSLKSPYLRALSSKLNAGGARSITVVLTAKDVTVEGLCMNRCGTHGSKSSSVNSGAYVWVGNSETQCPGYCAWPFHQPIYGPQSPPLVAPNGDVGVDGMIINIATLLVNTVTNPSPEAVSACTGIFGSGAYPGYAGRVLVDKTSGASYNALGLAGRKYLLPALWDPQTSTCKTMV
The following text describes a protein:
Function:
Component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDISINDCTDISQIKQRFHDLQVESQRTDEKLERLLSDAQPTEKFNSLIKNMAERLVLFVGQIEELKDAFCNTTIVSEEVIERIKSVDREQNRIKECLLFVRQVRDFKECLQDLNRAMHHQQWEKAADLVHRASSTSPAIIEGKFAHAVVPTAEQPLAPMDTLKEITESLHTLFWREFHKAARNQDQKEITRYFKLFPLIGKEKEGLEAYWHFFGGIIASKARATLDEPPTHALFFAQAFTGLVEHVASIIRAHTPLVQKYYKAKNTITVIEKLQGDCDRQGSIIVNTMFDVRRIDNLVSSIASYKYILLHAKLKNRAFVSDQKELERVSLQTLHPILNEMSAIVSKWNISKIFISRLVLRLSQSDGTSNDPSVQDNLICASIFNSSKMELLLKKQLLPSLLQLETYYFRRSIETSLELEEYYTKVSPWMSSIVDDVMYVTKQVFQRAFFTVSSLFFTRFVNESLIPILRNDYYVYLSHNLLTVCNIIKAQFQRLKNANSIPAKQVENYITLVNSASLSKQYLKSIVDGVSSRLEEVFAFAKDQKLVKKSIDNFLQLTVNFENLCKTSFNMYFPIFLLPRIEQCIDDSFDGINYVLSYEDYTKETEHERLVVTRLRSVWDRVLLLEQFTPENQLSLRSMACEKAASYIENLILYKIQWNDYGAMALENDISSLITIFSNDQANLRHSFERLQEILILLVWESDSTAPEQLINDLNLQLLSIDIVSAIMEKKANVQGED
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSIQHTLYRPLKEGASLAILGGGIGGLLSAAFLARARPDIKITLYESKAQCGGWIKSKLLECHDGGSEMIEKGPRTLRMHPGTLILLQAISHVDPKFSIYGLPTDSPANTKWILNKDQLMSLSVFKSPANLMRFLSSSVFRAMAMGAFNFLVYPWTRKRDPNVQDESVADFIGRRASPALGDRMGSAILHGIYAGDHKTLSARMTLRPFYGPDRLLKPAKLFTNEEFEKLYKKLFPEASTSLFDLKKFPAMFAFPQGLSGMIDVLHKHLEKSPNVEIKCNTEITRVETTIGGMLVSDSTGVSTTHNAVYSLLSYQAVSKLLPDTADRALIKDMSSVDVMVLNFSFEKPKDPKYTGFGYLIPQAEENPEQVLGVIFDSDVGRGSELISGEPYKSPSGRENVTVMMGGHYWKDGNIPSSEECVERAKKVLKRHIGLEVTDTTEYDVELHKSCIPQYAVGHLERVDQFKHIVSKETHHRVALAGMSFGRGVGISDAAVDAFLFVASQSHDPETLKLTRKIVDHYETTVRL
The following text describes a protein:
Function:
Has ribonuclease activity. May be involved in host-pathogen interactions.
Sequence:
AAAAVPRRGPRGGPGRSYTADAGYAPATPAAAGAAAGKATTEEQKLIEDINVGFKAAVAAAASVPAADKFKTFEAAFTSSSKAAAAKAPGLVPKLDAAYSVAYKAAVGATPEAKFDSFVASLTEALRVIAGALEVHAVKPVTEEPGMAKIPAGELQIIDKIDAAFKVAATAAATAPADDKFTVFEAAFNKAIKESTGGAYDTYKCIPSLEAAVKQAYAATVAAAPQVKYAVFEAALTKAITAMSEVQKVSQPATGAATVAAGAATTAAGAASGAATVAAGGYKV
The following text describes a protein:
Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular Localization:
Cytoplasm.
Sequence:
MSETIDNPTVEEYNEKETVVSGEQVEQVEQVEQENEQVSQSFQISIKTPAEIGTINIQVQPTDTLIDIQSFLYETSETCLYSSFEFRLYGKQIPEYSELSSIEGLVEGATLEMVPVDYNERSAKLHVKRLRDIMNTGLTEFANMNNPSLFTSFSFPEKSNILTEEQQLEEQKQKFEQQQQQQQQTEDKEEKETIATEQQQNKKNKHHNKKGNKKNNGDESLNNENNEEKLTPQQKERKQKMTEIKGIDKPMLSSYYPESPIAPVQCVKSMIYSGWSPVPGYRKLFGDLFYLDITLLEGTTICVTASTQGFFINQSSNATFNPSVSPKATINHSLHQLLTQVSRLFRRGLNQILTNIGRNHPFDMLPGVLPVHNWVASSKTNRYDINKGTDTFVSVQDVELRGNPRDWNEEIQAPKELPKSTVQERIIRDRAISKVNSEFVECAIRGAQVIVDKAILPINPAENQRSHMFLYNNIFFSYALDTRDSFTDCGGDDAARTSANNDLKGIRLYNLADIDGLYTLGTAIVDYKGQRIIAQSLIPGILTTEKTSKIYYGSMDTPTNEEEEQQQKEENEENKNNNTKSIKADPEFHSRLLQAASLLHLSESKVISEDTNQEVSVCTSFESKGIIGIDGRRYILDLIKATPRDPNYTETKDQLSVLRPEAIATYSEYFKVTWLNQKRQQKLKEKEERQKKEGIDPPTATARDEDVQLTEEDLAQSPVVSFNPNLFSKVKLGGTPEEQQKDIEDLKAIGAFLKGILIPRLIEDLMLFNVAPVDGQTLTQVMHVRGINMRYLGYIAKNESANVPFIQDLLFNEMVSRAAKHCFNRLLRSTNASDMAHSISHFLNCFLGTETGSVSADEKSKKAKQIKSSAINELTQGKLWSEIAQLVSSKFDFEIPTHSVPMESRLIVLRCICLKMGIQILAKDYNFTTDAPFSPEDIVDLFPIVKHVNPRSTDGLDLLEAGKTFFNQRKYELATELLGEALAIYHQVHGPIHPDAGACFTHLAMLAYQNEQYDLAIEYQKNALVITEKTAGLDHHETVQAYTTLAVFCQRSGRYNESIGYMKHVLYLTDLLGGEYNPERASIYTAIAAILEDTERFDLALEFLKQTLKHQEFLFTPDHLMCSTTYHKMAIVCARATNFDDSIIHQKKSTDILEKELGEAHPRTKESLEFYTGLSQTANQIKLFKQHQALKAEQDELARLQKEKADQFKKSQPRVSAMPPSLENGSVSELLNYINGKPKKSQSKKSKSTNTTTTTNTTTATTSKSKITMAKTPNPTTKATTSKSSATASSAATNKSTTKTNPTSSSAADSSKPNKKSSKN
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation. In its amyloid-like oligomeric form, acts as a translational activator. Up-regulated at activated synapses where it is required for the late phase of memory-related long-term synaptic facilitation. Sustained CPEB-mediated protein synthesis for at least 72 hours after neuronal stimulation is required for the persistance of synaptic facilitation. Activates translation of atypical protein kinase C. Required for the relocalization of syntaxin mRNA to the axon hillock from the opposite pole in the cell body of sensory neurons during long-term facilitation.
Subcellular Localization:
Synapse, synaptosome. Cytoplasmic granule. Note=In sensory neurons, detected in cytoplasmic granules composed of proteins and RNA.
Domain:
The N-terminal Gln-rich domain can confer two distinct functional states, a dominant active prion-like aggregated state and a soluble state.
Sequence:
MSQSPQTVDQAISVKTDYEDNQQEHIPSNFEIFRRINALLDNSLEANNVSCSQSQSQQQQQQTQQQQQQQQQQQQQQHLQQVQQQQLLKQQQQQAQQQQIQQQLLQQQQQKQQLQQQQQQEQLQQQQLQLQQQLQQQLQHIQKEPSSHTYTPGPSPELQSVLNYANVPLSKSAAFNCNNSSSYSVGPTPVQSPVTPSPAASAVTVNSPSYGNFQLFGENAFDSTTPFQSDGTSQSHSRSLANDSDPMVVMSPGRDSIIPLSPTEKILYQNFLLSKQAQGENTALPPSPPHEIMPLSPLEKKLYSNLLSKHTQGMRAINSTSPLQTPLTPPRSPQEVLYASMPAAQVGESSSVIDMMSRMDLSGRNQQADYSGTLAFLDAHNVLRRRTPSSSRSRSVMERSAPSSYFANLDPYAIDRAARLHRNAAAVGEASCTWSGHLPPRNHENPVYSPKVFLGGVPWDITESGLQAAFSKYGHLKIEWPGKDGYVHLLFDVEKSVRSLLQACTHDFSNGDYFYKISSRRMRSKEVQVIPWVLADSNHVFQPSQRLESNKTVFVGALHGMITAEALGRIMSDLFGNVVYAGIDTDKHKYPIGSGRVTFSSRKSYMKAVQAAFVEIKTPKFTKKLQVDPYLGDAICSLCNSHQGNYFCRDLLCFKYLCRSCWYWQHAPDSMRQHRPLTRNTKSSLSL
The following text describes a protein:
Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen; Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Domain:
Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain. NC1 domain mediates hexamerization of alpha chains of type IV collagen.
Sequence:
MGPRLSVWLLLLFAALLLHEERSRAAAKGDCGGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPHGPPGQKGDAGEPGLPGTKGTRGPPGAAGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFSGNPGPPGLPGMKGDPGEILGHVPGTLLKGERGFPGIPGMPGSPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGSSFQGPKGDKGEQGVSGPPGVPGQAQVKEKGDFAPTGEKGQKGEPGFPGVPGYGEKGEPGKQGPRGKPGKDGEKGERGSPGIPGDSGYPGLPGRQGPQGEKGEAGLPGPPGTVIGTMPLGEKGDRGYPGAPGLRGEPGPKGFPGTPGQPGPPGFPTPGQAGAPGFPGERGEKGDQGFPGVSLPGPSGRDGAPGPPGPPGPPGQPGHTNGIVECQPGPPGDQGPPGTPGQPGLTGEVGQKGQKGESCLACDTEGLRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGLEGLPGPQGSPGLIGQPGAKGEPGEIFFDMRLKGDKGDPGFPGQPGMPGRAGTPGRDGHPGLPGPKGSPGSIGLKGERGPPGGVGFPGSRGDIGPPGPPGVGPIGPVGEKGQAGFPGGPGSPGLPGPKGEAGKVVPLPGPPGAAGLPGSPGFPGPQGDRGFPGTPGRPGIPGEKGAVGQPGIGFPGLPGPKGVDGLPGEIGRPGSPGRPGFNGLPGNPGPQGQKGEPGIGLPGLKGQPGLPGIPGTPGEKGSIGGPGVPGEQGLTGPPGLQGIRGDPGPPGVQGPAGPPGVPGIGPPGAMGPPGGQGPPGSSGPPGIKGEKGFPGFPGLDMPGPKGDKGSQGLPGLTGQSGLPGLPGQQGTPGVPGFPGSKGEMGVMGTPGQPGSPGPAGTPGLPGEKGDHGLPGSSGPRGDPGFKGDKGDVGLPGMPGSMEHVDMGSMKGQKGDQGEKGQIGPTGDKGSRGDPGTPGVPGKDGQAGHPGQPGPKGDPGLSGTPGSPGLPGPKGSVGGMGLPGSPGEKGVPGIPGSQGVPGSPGEKGAKGEKGQSGLPGIGIPGRPGDKGDQGLAGFPGSPGEKGEKGSAGTPGMPGSPGPRGSPGNIGHPGSPGLPGEKGDKGLPGLDGVPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEQGVPGRGFPGFPGSKGDKGSKGEVGFPGLAGSPGIPGVKGEQGFMGPPGPQGQPGLPGTPGHPVEGPKGDRGPQGQPGLPGHPGPMGPPGFPGINGPKGDKGNQGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGLPGVPGFQGQKGLPGLQGVKGDQGDQGVPGPKGLQGPPGPPGPYDVIKGEPGLPGPEGPPGLKGLQGPPGPKGQQGVTGSVGLPGPPGVPGFDGAPGQKGETGPFGPPGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTTDDPLCPPGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPISGDNIRPFISRCAVCEAPAMVMAVHSQTIQIPQCPNGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT
The following text describes a protein:
Function:
Transcriptional regulator which is part of the latency-replication switch system that decides at the onset of infection whether to replicate and lyse the host or to lysogenize (latency) and keep the host viable. Activates the transcription of the aimX locus. Transcriptional activation of aimX seems to lead to the productive viral replication (lytic cycle), aimX possibly acting as a regulatory non-coding RNA.
Sequence:
MIKNECEKDNQLAARLAKLAGYEKVNGFYKFVNTPEKEMENLGGLLKIVKNLFPDSEEQLLSEYFLELDPNKKCARQSVEYSDINQWDTLTDKIIINLCNSKNSTSQEWGKVYSLHRKLNKNEISLNDAIRESGKCKIKSAEMLFFSNAMLMYAYLNIGEFGLMKSTSKLLEFDDLPEGFIKESFKSRVSMLEANISLNENSLLEARQHSNRAIENSNVNRICFFAYLTIGNTLIFEDYDEAKKAYIKGQKYAKNPVHQEMLDGALCFLSNIWKKENQWVNYNSDNIKYLQLRAFYYINQGNIEEATEILDELSSRDQDENELGFYYYYKGLISQDKTDYYKSIRYFKKSDDKYFIQLPLLQLERMGADLELLNLISI
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MAKQWYVVHTMSGFEEKVKASIEERVKTKGLEDKISRILIPTEKIIEVKGKKKKEQEKKFYPGYILVEMELNDDTWHLISTTQRVTGFVGGKKPAPIPQEEVEMILQQLEKGRAPQIKAHFEKGETVRITDGPFTNFTGYIDEVDSEHERVKVMVSIFGRQTPVELAFSQVEKV
The following text describes a protein:
Function:
May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
Subcellular Localization:
Nucleus.
Sequence:
MKLYSIVILEGLQCSCLIPSSTMNTALHNPLKSLGEDFYREAIEHCRSYNARLCAERSMRLPFLDSQTGVAQNNCYIWMEKTHRGPGLSPGQIYTYPARCWRKKRRLDILEDPRLRPCEFKLDYEVPMKKESSLPEGPVLEALLCAETVDKKLELKEEEAVSDCQKPQIGEIPHELEGEDLDDDTPKRKNRTKGKACGIGGMKKRQDLSTLEDRDKPYVCDICGKRYKNRPGLSYHYTHTHLAEEEGEENAERYLIPFHRKNNHKHFYKELNWVPEMQPRHTIKKAPDGSVIANGYCDFCLGGAKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECKSCTLCGTSENDDQLLFCDDCDRGYHMYCLSPPMSEPPEGSWSCHLCLRQLKEKASAYITLT
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.
Sequence:
MFCFSRFALCAAAPRVLVTGALGQIGTDLSLALRDKFGADSVLVSDVVEPGAKHPLAGLKGVEKLDCLDSNGFEKLVKEFKPTWMYHLPAIMSVRGEAEPDLAMDINVNTTRYALELARKYNIRIFIPSTIAAFGDKCGKTMTKDDTIMNPSTVYGVTKVYTELLGTWYRQKYGVDFRSVRLPGIISAATLPGGGATDYAIHMYHSALLQKKCVCPVLPYESLPMMYMPDTLNSLVKIMEAPLEKLTRTVYNITGFSFSPSELRFSIERCTDRTIEVEYVEGPAQKIANSWPDSLDDSNARNDWGHQVKYDIDMMSEDMLRQIPILHGLPSL
The following text describes a protein:
Function:
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MAPPQAPNRDRAGQEDEDRWEARGDRKARKPLVEKKRRARINESLQELRLLLAGTEVQAKLENAEVLELTVRRVQGALRGRARGEWRRGSRAGALTGHACHPRAGHVGSRSLGPVHGEGSPQSRTR
The following text describes a protein:
Function:
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M.
Sequence:
MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLRQ
The following text describes a protein:
Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane. Mitochondrion matrix.
Sequence:
MAGSSSEERGFEAALEAISSLITRRKRADGSNWGDAFALMDTYIKILDLEEPLSRLSVIHVAGTKGKGSTCAFAESILRHSGNKTGMFTSPHLVDVRERFRIRGELVPKDVFLEHFWWCWDRFQAAATPDVPLPAYFRFLTLLALRIFIAEKVDVALLEVGIGGRYDATNVVRAPVVCGVASLGYDHTELLGDTLPLIAAEKAGIFKPRVPAITAPQPDDAMEALQKRADELQISLDVAPPLESLEDPSAISLGLAGDHQRINAALAVALCRAWTERAGPTAQLDNLRQAMQRKRLPDSFRRGLASVEWPGRAQIMPDTEIQAPGESPQGSLMFYLDGAHTPESMEVCATWFCESVAGGAETAETSEGGQKVGHQDPPEGSGEAAERPGLQNGLGLAADLERVNGEERDGRTDRTGLGSEGLNVRRVLLFNCMQEREPVKLLDPLIRIAHGKGVSFHRAIFVPSFSSSTSITTLSSTPDLTWQQTQLQTWTSILHKLGPTLNRKPNPVPPTAPAGAAEQPDRNGSHVASARDGDVSWDGSGFVMPSLPAALEWLRKAAREQPPGRLQVLVSGSLHLVGDVLRLLKH
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence:
MAPKAAEKEPATEKAAEKKPAEKEPATEKAAEKEPAAEKAAEKKPAEKEPATEKAAEKSPATAGKKPEAKKRLPAGEMASKAGGGKKRGQKEGKRRKETYKVHIYRVLKHVHGKELGITSKAMASMNSFVNDMFERLAAEAGKLARYNKKSTIGPREIRTSVRLLLPGSLSTTAFKAGDAAVDSFKNYKVFYVSSEEE
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MATEGKKMVTLKSNDDKEFEVEEAAVIQSEMIKNMIEDGCATSVIPLPNIDSNTLSKVIEYLNKHITRDEDEDEDDDKDKGKEAETGDEEDLKEFDEKFVNMGWEELFDIIMAANYLNIHELMELCCQSAADRLKNKSVRAVREMLKITNDLTEEEEKEIINDAPWAFEGPEIDDTVN