lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MSFPTFNFGGNNGLATPGKSRNIFGNGEPPSPSNSFTPQGPPPSTIYGGSQMSARSPANSNPIFNRSELLNDSIFGSSVDSPDFASRTKQTAAAKRFTASESLFDVSRGPSFDESTNWGASNGFQPHMSGGLGADDGKSMEEDEDEDEAEQTGKTRGSGLNFLDSHMSSTGPSSIPAQRKPIYANPGNAKRPKLDEKWANQSPLRNAKLSPKKNSTIPAIVRNFAARTRKATVDEPFDFIIRTEDEISRMYEETRQTQYNNEYLQETIGKICADLSTVWYNSSESKASGTVIGPGDNAANSTKAGFLGALLLQLHHPPATKSTGFPNTFGLAAPRYTFGGRSASAPIPKVLLDWLNVNKPLSDEITALKQVEPDPTASPSFWEIVIAAVLRGQLSEASQILRSADFNYARSALEDGLPQAGYRGVQLQNIQRCINKALQVLEACPSVHNDNWDARDAEWSLYRKRVHTAISDLEEFAEGEEQPAPAPATGNTFQAINFGLGSNPFQGPSFTESARMAESRVPWTIYQNLRSVYRIILGDPAAIMNYAESWVEATIGLTVWWDGEDDEEASPPPFLRRGQSPSNDPYLRRLSLAFKHATSTEKDEKGFRYNSLSGIEVGLAAVFEGDVAGVLELLQTWSLCVAAAVAEISSVGGWLETKSNAKPPGLSDNDLMVLSYNQNDAPAGVSRDDVLSAYATGLSERPSIGNEHEGREGWELALEVLSRLDDSQKMQKSVSELLDKLPLDTAEQMDKVVLLCSELGLNKEGRRVSERYGDLTVSNSEEYGLALVCYARAHNRRKVKSVVDLLISYSLVQSRAYPASSDLDEQLRTLIREPKTCLSAIAHADEEAASILQFYFSGYATLRRFYETRDEAVNLPAGQKPRYKPLARRRAAAQALVAVISSAADSIYGGLYDPDRDSAIQVDGLLALLGEALPFVHQSSSILNPSQQFAILSAIEDLETVTPRVYAQCEECFRSTLLEYYSKQAGKASDSYVLPPSPRALLKKSVSSLTASSTFSIIGSDMLGARTRSSSGSAEGSGVLVPRDCEKTPLVREWDWRAGLPEDTKGEDVLRMLRLGLANGLTLEALGRAY
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MARYDRAITVFSPDGHLFQVEYALEAVRKGNAAVGVRGTDTVVLGVEKKSTPKLQDSRSVRKIASLDTHIALACAGLKADARVLINRARVECQSHRLTVEDPVTVEYITRYIAGLQQKYTQSGGVRPFGLSTLIVGFDPYTDKPALYQTDPSGTFSAWKANATGRNSNSMREFLEKNYKETSGKETIKLAIRALLEVVESGGKNIEVAVMTKKDGLRELEEAEVDEYVAEIEAEKAAAEAAKKGAPKDT
The following text describes a protein:
Function:
Involved in non-homologous repair of DNA double-strand breaks. Stabilizes DNL4.
Miscellaneous:
MISCELLANEOUS: Present with 876 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSQLTEFISCIPVVNEEQNEEDERGLCKIQIEDGAMLETLDENSLSGLRIEKMLVSEGTGIFSKSSFGINDLRIFTGENIDEESKKYVWYELLKMLTGHKVYIASLDEKVVFTKWTCRMQDDEVWKVVMELESSAIIRKIAELTLHPVKKGEIDLFEMADKLYKDICCVNDSYRNIKESDSSNRNRVEQLARERELLDKLLETRDERTRAMMVTLLNEKKKKIRELHEILRQNNIKLSDDDVLDSALINTEVQKPISELNSPGKRMKRRKTVVEPQNLQKKLKDTSRRRANRKISNQSVIKMEDDDFDDFQFFGLSKRPIITAKDKLSEKYDDITSFGDDTQSISFESDSSSDVQKHLVSLEDNGIQISAGRSDEDYGDISGSESETDASAGEKKSSNHSEQSGNDREPCLQTESETDIET
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MATLPPDHIRLQADLEFVHLLANLEYVQSLLDAQYFEDESFRAYLRYLQYVRRPEYSCYVKYPRALYMLEKLTEPAFYSALLAPVGECHGLSRLAVYMQQDALDSQFFEEDRAEMEAITAQLAMRSPETE
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTSADIRDVFELPPPEIGNKQKSKTPTERRPEGISRELYSLLGENSAPLAIYQKKFKEKPKVSHKAKNWVRQPFSISSRKDDFTLHHWVLKSEVDSEASYKFEKFNVPLFIIDYTDEEYQNYLKDEDWNKDETDYLFRLCKDYDLRFFVIADRYDNEKYKKHRTLEDLKDRFYSVSRKILLARNPINSMTAAQSSLLNTMEYNKEQEVIRKKYLIGLASRTPEEVAEEEALFIELKRIETSQAKLLSDRDEVLRLLDEQKGDGGIHEYHTSAGMSSLIQDMINSQRTKNKVEEAIVSSSAPSSGVSSVLNTPTRPHALSTPRIRYGPQPTDPQFGITWHEKLHPGTFVRSQKIPAIKASLSQRVSSVMTELGVSSRLIMPTAKNFEKFVELQNSIVSLLELKRKVDRLSQETEIQDKLSRKRSASPDGSESKKHISQ
The following text describes a protein:
Function:
Probable transporter of a GTP-driven Fe(2+) uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MTALTPGLPLPEAPLTAPRLPDEDACRRTLARLREVSEPRVVVVGNPNTGKTTLINAVAGTNLKVGNWAGVTVEKREARLRVGGRDVQLLDLPGAYSLSPHTPEELVTRTALLDEAPDVILNVLDAGNLERNLYLTLQLLDFQVPVAVALNLIDEAREKGMEVDAAALSRALGVPVTETVANRGRGTDRVLTQALDGATLGIGVRYPQPIEAAVTDLTRRMSEQATLPPHAWRYIALALLEGDPSVRGRLSATGHLDLIERADGHLKALDAQGIDALIDIAEARYARAGDLARLAVPQVQARRTLSEKLDRLTLHPVLGVPLFLALVLLVFRLTFSVAAPFVDLIGGPLQETVAGWAAAALAWFPLGRDIVVGAIIPGVGTVLSFLPTLLVLYLAMSFLEDSGYMARAAFLMDRAMRSLGLDGRAFIPLILGFGCNVPAVSATRTLERRSDRIVVSMILPFMSCSARLPVYVIFAAALFPRSGSWVVWGMYVLGMLVAFAFAWVLRKTSYPSEGGGVLLELPPYRFPAWKVLWKHAWRRTASFARRARTTVLATVAGVWFLLALPAVSGGHFATVPPQDSVFGKVAQAASPIFAPLGFGDWQATGALVPGFIAKEVVVGTLGQIYLGEQAAAPAPVGLLTGLENAALATWDAVKASVSALPTVLALPSFGTDTTADQKSPLAAALSRAFTPASGLSYLVFVLLYTPCIVTVGAIAQEHGRRVAWLTVAYQLIIAWVTAFIVYQIARGLL
The following text describes a protein:
Function:
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Sequence:
MSRNLYVEKDVCISCGLCVETVPEVFRFDDDNLAEVYDPAGAAEEKIQEAVDTCPVSCIHWG
The following text describes a protein:
Function:
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Subcellular Localization:
Nucleus.
Sequence:
MVEKEEAGGGISQEEQICLRGLEAPKWLRASQVLLVSMKGLGAEIAKNLILAGVKGLTMLDHEQISPEEPGAQFLIHIGSVGRNRAEASLERAQNLNPMVDVKLDTEDIEKKPESFFTQFDAVAVIVKVDQICHKNSIKFFAGDVFSYHGYTFANLGEHEFVEEKTKVAKVSRGVEDEPDTKRVKPDSSETTMVKKKVVFCPVKEGLDVDWSSEKAKAALKRTTSDHFLLQVLLKFRTDKGRDPSSDTHGEDSELLLQIRNDVLDSLGIIPDPRFITDFFSEMAPVCAVVGGILAQEIVKALSQQDPPHNFFFNGMKGNGIVEWLGPK
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MIDLYLCHGHVYVWNATDACDLREHHRIVGTFVGALPRLPRQNVRLGRPLQLMPEETTVLLNKGIARLLDGNIPPKTGEDVSQAITEHRQQSFREQAEMCKSDRKRKLHEMASVIAKGRAAKRKKLAQKAKEESSSSVSTSDVSSSTCDQPEDEEPSLSVEEMKELEAKLEETTGYNEQAFLVQILTEQVSEETQDAIPWKYPNTDKETLRCNVFQDLWEKGYFLTSGGKFGGDFLVYPGDPFRYHSFYIAVCQQRTEKMEALDIVRLGRLGSNVKKTVLLCSESETGEINYTSLQWTGMN
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MPKLLISLAILYLLVLVKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTDYDREKNLAEDPIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKDIIAIAPEMPTLKDVEEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADEEIEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEKVSLQRALSRLKMNIRIGKEPAEKKNKSKRVYKKCCSSECRPTAKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLARTVTVSKDGNYTEDPDRTTKGTWLVENNALIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLEDAELDNFSDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQIFRRPCLTSI
The following text describes a protein:
Function:
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures. Binds to ssDNA.
Subcellular Localization:
Cytoplasm.
Domain:
Composed of two independent domains separated by a small linker. The N-terminal region contains the ssDNA binding site and the C-terminal region contains the nuclease active site.
Sequence:
MRKVIIKENPSEEEIKELLDLAEKHGGVVTIFARCKVHYEGRAKSELGEGDRIIIIKPDGSFLIHQNKKREPVNWQPPGSKVTFKENSIISIRRRPYERLEVEIIEPYSLVVFLAEDYEELALTGSEAEMANLIFENPRVIEEGFKPIYREKPIRHGIVDVMGVDKDGNIVVLELKRRKADLHAVSQLKRYVDSLKEEYGENVRGILVAPSLTEGAKKLLEKEGLEFRKLEPPKKGNEKRSKQKTLDFFTP
The following text describes a protein:
Function:
Monooxygenase catalytic activity. Involved in regulation of cytokinesis; promotes RHOA activity, probably acting locally at the midbody in late cytokinesis. Monooxygenase activity is involved in stabilizing transient structures between daughter cells, termed intercellular bridges, before abscission. Regulates differentiation and proliferation through the regulation of cell death.
Subcellular Localization:
Midbody.
Sequence:
MSNWRKDHLGASSSEPLPVVIIGNGPSGICLSYLLSGYTPYVKPDAVHPHPLLQRKLSEAPGVSITDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNTESVLTWKYQKERAIPHLVLGRNLPGGAWHSIEGSMVTLSQGQWMGLPDLQVKDWMCRKRRGLRNSRATAGDIAHYYRDYVIKKGLSHNFVSRAVVTAVDWGMPEPSGPGTQDPSPLFQVRGFVTAEDQSQQPFSLCARNVVLATGTSDSPARLGIPGEALPFVHHHLSALEAATRAGKVTPSSDPVLIIGAGLSAADAVLYARHYNVPVIHAFRRPVDDPGLVFNQLPKMLYPEYHKVHQMMREQSILSPSPYEGYCSLPEHQLLRFKEDRQAVFRNPQGLQKVFGVSLVLVLIGSHPDLSFLPGAGADLAMDPDQPLSAKRNPIDVDPFTYQSTHQEGLYAMGPLAGDNFVRFVQGGALAVASSLLSKEGRKPP
The following text describes a protein:
Function:
Acts as a transcriptional coactivator of ATF2.
Subcellular Localization:
Nucleus.
Domain:
The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
Sequence:
MLLRPRRPPPLAPPAPPSPASPDPEPRTPGDAPGTPPRRPASPSALGELGLPVSPGSAQRTPWSARETELLLGTLLQPAVWRALLLDRRQALPTYRRVSAALAQQQVRRTPAQCRRRYKFLKDKFREAHGQPPGPFDEQIRKLMGLLGDNGRKRPRRRSPGSGRPQRARRPVPNAHAPAPSEPDATPLPTARDRDADPTWTLRFSPSPPKSADASPAPGSPPAPAPTALATCIPEDRAPVRGPGSPPPPPAREDPDSPPGRPEDCAPPPAAPPSLNTALLQTLGHLGDIANILGPLRDQLLTLNQHVEQLRGAFDQTVSLAVGFILGSAAAERGVLRDPCQ
The following text describes a protein:
Function:
Can release basic, acidic, aromatic, and, to a lesser extent, aliphatic amino acids.
Sequence:
MDLVEKLKNDVKEIEDWIIQIRRKIHENPELSYKEYSTSKLVAETLRKLGIEVEEGVGLPTAVVGKIRGNKPGKTVALRADMDALPVEETSDVEFKSKVKGVMHACGHDTHVAMLLGGAYLLVKNKDLISGEIRLIFQPAEEDGGLGGAKPMIEAGVMNGVDYVFGIHISSSYPSGVFATRKGPIMATPDAFKIVVHGKGGHGSAPHETIDPIFISLQIANAIYGITARQIDPVQPFVISITTIHSGTKDNIIPDDAEMQGTIRSLDENVRSKAKDYMRRIVSSICGIYGATCEVKFMEDVYPITVNNPEVTDEVMKILSSISTVVETEPVLGAEDFSRFLQKAPGMYFFLGTRNEKKGCIYPNHSSKFCVDEDVLKLGALAHALLAIKFSNK
The following text describes a protein:
Function:
Uses inorganic polyphosphate (polyP) as a donor to convert ADP to ATP.
Sequence:
MDSYGDTSGRIGRDWLDRHDEELEQELLDDELNLDELFGPEQEDAPGELSRRRYFRELFRLQRELVKLQNWVVHTGHKVVILFEGRDAAGKGGVIKRITQRLNPRVCRVAALPAPNDREQTQWYFQRYVSHLPAGGEIVLFDRSWYNRAGVERVMGFCNDEQYEEFFRSVPEFEKMLARSGIQLLKYWFSISDAEQHLRFLSRIHDPLKQWKLSPMDLESRRRWEAYTKAKETMLERTHIPEAPWWVVQADDKKRARLNCIHHLLQQMPYREVPQPPVHLPERLRHADYVRHPTPGEIIVPEVY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSSSPINENDNGNIENNNETNITENGDNGESIDKKDDNIVLPYENDEEEANYLRFIMELEFIQCLSNPRYLNYLAQNRYFQDKAFVNYLVYLQYWKKPEYAKFIVYPQSLYFLDLLQEERFRQELNHSQSTDFIHEQQFYHWQYYRNNRMSIKEQELQQQQQQQQQQQVQPPTTV
The following text describes a protein:
Function:
Component of the elongator complex, a multiprotein complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitivity to Pichia inositovora toxin.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFRKRGEILNDRGSGLRGPLLRGPPRTSSTPLRTGNRRAPGNVPLSDTTARLKKLNIADESKTKMGLDSSHVGVRPSPATSQPTTSTGSADLDSILGHMGLPLGNSVLVEEQSTTEFHSILGKLFAAQGIVHNRISDSSADKTRNGDTHVIVLSLNQMFAKELPGIYKGSRKQMKKNLISEEESKVTVQNLNETQRSTPSRYKDLKIAWKYKLADEKRLGSPDRDDIQQNSEYKDYNHQFDITTRLMPAPIASELTFIAPTQPVSTILSQIEQTIKRNDKKLIRIVIPSLLHPAMYPPKMFESSEIIGLMHGVRSLVKKYYERVVLFASISIDIITPPLLVLLRNMFDSVINLEPFNQEMTEFLERVYKSQPGKIQHGLVHILKLPVFTDRGEMRVLKSEWAFKNGRKKFEIEQWGIPVDDAEGSAASEQSHSHSHSDEISHNIPAKKTKISLDY
The following text describes a protein:
Function:
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.
Subcellular Localization:
Chromosome. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MRYKAVGKQCACISRSRADPGSVRVAVREQGRERACGRARSWVRAARSVARMCVCAGYRAAPSWPGAGPLQVAGGRSEGADMDFDSYQHYFYDYDCGEDFYRSTAPSEDIWKKFELVPSPPTSPPWGLVPGAGDLVPGIGSPEPWPGGGAGDEVESRGHSKAWGRNYASIIRRDCMWSGFSARERLERAVSDRLAAGAPRGNPPKTPAAPDCAPSLETGNPAPAAPCVLGEPKTQACSGSESPSDSEGEEIDVVTVDKRQSLGVRKPVTITVRADPLDPCMKHFHISIHQQQHNYAARFPPESCSQGGASESGPQEEALERDAPEEKEDEADEEIVSPPPVESEAPQSCHPKPVSSDTEDVTKRKNHNFLERKRRNDLRSRFLALRDQVPTLASCSKAPKVVILSKALEYLQALVGAEKRMATEKRQLRCRQQQLQKRIAYLSGY
The following text describes a protein:
Function:
Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MLLIRRTINAFLGCIHCNLTATCILIAFVITMYVVLVSEPASVDGTMGNFLPFSKMDLATKRDRPFYSNCVNTQDYLLNPSYIKQNASFVMLTRNGELEDVIKTINSIEEHFNQWFHYPYVFLNDQPFEEDFKAKVRDVTVGALVEFGTIDEISWNFPSDVKDTFEFYNAIEDQGDRSILYGNLESYHKMCRFYSGLFYKHPLVQKYEWYWRLEPDVEFFCDITYDPFLEMLRTNKKYGFTIIIPELYWTVPNLFRHTKSFISQKGVTLGSLWKLFTKDYDIFESDDPELRDWINYDFQAKAKISEKIAIEQLLKKGDDFQQINDDKEGIMNLIHKARSRKHIVEDKFFNEEYNLCHFWSNFEIARLSVFDNDIYNSFFQYLEKSGGFWKERWGDAPVHSIGLSLTLDLDDVHYFRDIGYRHSTIQHCPHNAMGNEEFSYLASDSKFKRKNAAYDEGREFGCGCRCRCPKKKREIEDSMGFCVNIWVNLLNQQRGHERHVEALNGNEMEEHIREDYLRQFGN
The following text describes a protein:
Function:
Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein.
Sequence:
MQTVRSYFFGPTPQEQNRKWQSIIRKEQRQLDRQVYHLKAGRKKAEVQLKQLAKQSDITNMRILAKEIARANRHGKRLAESKALLGSLSLQLNDQMAMLKIQGTMQSSTKIMQDVSSLIRLPQLSETMRNLSMELTKAGVLEEMRDEMFLPVEDDEELMDLADEDEEVQEILTKYNVIPAPSEKAADAATHREQSLKQALPSLSNGIAKDSTEIDEEQLLDIRDKLDALKS
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Sequence:
MRIVFIGPPGAGKGTQCELLSKALKVPHIGTGGMLRALEPESGEQIHLRIDRGHFAPDDFVLQMVAERLSQPDSRTGYLLDGFPRTQVQASAFDKQLVAASLKLDHVLHLQVSADVLIERLRKRGETENRADDSEEFIRERFRIYEDRTAPLLDHYRCQGLVRDIDASDSESLVHASICECLNFTLASPAES
The following text describes a protein:
Function:
Transcription regulator that may repress the maturation program during early embryogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MEDDEDIRSQGSDSPDPSSSPPAGRITVTVASAGPPSYSLTPPGNSSQKDPDALALALLPIQASGGGNNSSGRPTGGGGREDCWSEAATAVLIDAWGERYLELSRGNLKQKHWKEVAEIVSSREDYGKIPKTDIQCKNRIDTVKKKYKQEKVRIANGGGRSRWVFFDKLDRLIGSTAKIPTATSGVSGPVGGLHKIPMGIPMGSRSNLYHQQAKAATPPFNNLDRLIGATARVSAASFGGSGGGGGGGSVNVPMGIPMSSRSAPFGQQGRTLPQQGRTLPQQQQQGMMVKRCSESKRWRFRKRNASDSDSESEAAMSDDSGDSLPPPPLSKRMKTEEKKKQDGDGVGNKWRELTRAIMRFGEAYEQTENAKLQQVVEMEKERMKFLKELELQRMQFFVKTQLEISQLKQQHGRRMGNTSNDHHHSRKNNINAIVNNNNDLGNN
The following text describes a protein:
Function:
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Subcellular Localization:
Cytoplasm.
Sequence:
MDASSSSNPDDGLQAIRLVDASDDEPYADAVAKIERCQEILGYDFRDLDLLRSALTHASGASHRLASNERLEFLGDSVLGLTVCEWLFNEYPEYSEGDLTKIKSAVVSRRSCGKVACKLGLDQCLIVGRGVTRNRSYPKSLVSDVFEAVIAALYIDGGPEIVRDRLKLWLAEEVNLAVDTQGSGNHKSVLQQFAQRELSATPVYKLIRETGPDHRKMFLMGAMVDDRRFAPAWGNNKKDAEQRAAANALAELHNAKVPYDSEQPPA
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MAGGAAQPGAELLNFAQFRDSSAQRLAYGYGARSLRELRAREFGRLAGTVYLDHAGATLFSQSQLTSFTKDLVENVYGNPHSQNVSSKLTHDTVEQVRYRILAHFHTSPDDYSVIFTAGCTAALKLVAEAFPWVSPGPESSGSRFCYLTDSHTSVVGMRKVTMAMNVTSIPVRPEDLWSAEKLATATSNPNCRLPHLFCYPAQSNFSGTRYPLSWIGEVKSGRMCPVSVPGKWFVLLDAASHVSTSPLDLSVHQADFVPLSFYKIFGFPTGLGALLVNNRTAPLLRKTYFGGGTAAAYLAGEDFYVPRQSVVERFEDGTISFLDVIALKHGFDALERLTGGMENIKQHTFTLAQYTYTALAALRYPNGAPVVQIYSDSEFSSPEVQGPIINFNVLDDSGNIIGYSEVDKMASLYNIHLRTGCFCNTGACQRHLGISNEMVKKHHQAGHICGDNVDLVDGQPTGSVRISFGYMSTLEDAQAFLRFIIATRLRPSDGQHLLQATPGEAAVPRAESEVQSAVPATMDRCSPSPQEDAPTGSQVWNDLPTAVDAVALHPPLPEATRTQQTPSEQAAGVPEGGLGPHVVTNLYLYPIKSCAAFEVTKWPLGKQGLLYDRSWMVVNHNGICLSQKQEPRLCLIQPFIDLQQRIMVIKAKGMEPIEVPLEENSERAQICQSKVCADRVNTYDCGEKISSWLSKFFGRPCHLIKQSSNFQRNARKKHSKDQSPGTTAALSLVNEAQYLLINRSSVLELHQRLNTSDENRKVELFPMKDLISRFRANIITNGTRAFEEEKWDEISIGSLRFQVSGPCHRCQVICIDQHTGQRNQDVFQKLSETRERKVNFGVYLMHTSLDLSSPRFLSVGSQVPGLQK
The following text describes a protein:
Function:
D-mannose/D-glucose-binding lectin that also binds derivatives N-acetyl-D-glucosamine and alpha-methyl-D-mannopyranoside (Ref.1). Does not bind D-galactose, L-Rhamnose, D-fructose, lactose or glycoproteins fetiun and mucin (Ref.1). Shows agglutinating activity towards human and rabbit erythrocytes (Ref.1). Also displays antimicrobial activity against L.infantum (Ref.1).
Sequence:
QLKGMISVGPWGGQGGDHWSFKANHAITEILIHVKDNIKSISFKDASGDISGTFGGKDPRENEKGDEKKIGIHWPTEYLKSISGSYGDYNGLLVIRSLSFITNLTTYGSFGSTSGGESFSIPIADSVVVGFHGRGGYYLDALGVFVKPVPHGTISFGPWGGPAGDDAFNFKVGSWIKDIIIYSNGAIQSIAFKDGNGHCYGKFGGKDPNDIGVEKKVEIDGNLEHLTSISGTYGNYKGFEVVTSLSFITNVTKHGPFGTASGTSFSIPIEGSLVTGFHGKGGYYLDSIGIYVKPRDVEGSISIGPWGGSGGDPWSYTANEGINQIIIYAGSDIKSLAFKDTSGFDSATFGGVNPKDTGEKNTVSINWPSEYLTSISGTYGQYKFKDVFTTITSLSFTTNLATYGPFGKASGTSFSVPINNNTVLGFHGRAGDYLDAIGIFVKPDTAV
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSRSALWRQEANVKDRERKAEECFRVAIEEGRACHPKGLIPLACPDDTFNIHPMLLQNIAKSPYFQKCCEKLGDWNTLVDEIYYEVKHMEPWTAGASKSPSTAFCLLLRLFTLRCTEKQMSLMLEHVDSPYIRCIGFLYLRYAAEPSTLWSWYEQYLYDEEPVQIRQGKADTTVGEYIRSLLEDLEYYGTRLPRLPLTLERQFKVKLLQAERVEERAKQHEKNTAAMEYFQKLGSRLQALYGDEENPVTWYDAVVDRVILRDAESGELLKRPKFQVTFPEYGNTEIVTLGEVDLPGSHTAGSAPASGSDVRSPVRRGDERDRGRGYRYDERDRGRGRYSDDRRRGSRDFDRRDIRSDERDYPDSRRLERSRSRDREGFSPSNDVRAKVREAEERELMEEVLRREREKSAAKGKSYASRPTSFKDSLGDRVESRHKVDAEWKPPPKPRADVQDSKPAAAPVVKKTAAELAAIEDKKRRLLAKYG
The following text describes a protein:
Function:
Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Lipid-anchor.
Domain:
The UIM domains specifically bind 'Lys-48'-linked ubiquitin polymers. The UIM domains mediate interaction with polyubiquitinated proteins.
Sequence:
MEFPDLGAHCSEPSCQRLDFLPLKCDACSGIFCADHVAYAQHHCGSAYQKDIQVPVCPLCNVPVPVARGEPPDRAVGEHIDRDCRSDPAQQKRKIFTNKCERAGCRQREMMKLTCERCSRNFCIKHRHPLDHDCSGEGHPTSRAGLAAISRAQAVASTSTVPSPSQTMPSCTSPSRATTRSPSWTAPPVIALQNGLSEDEALQRALEMSLAETKPQVPSCQEEEDLALAQALSASEAEYQRQQAQSRSSKPSNCSLC
The following text describes a protein:
Function:
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.
Subcellular Localization:
Nucleus.
Sequence:
MSSAKEGLGNCQLPISRIRTIMKSSPEVNSIGNDSLFLIAKATELFVQNLAQLAYEKSCNKELVDYNDLADIINKKEQLQFLQDIIPKKMKYKDYLEMVKKKEIIVIK
The following text describes a protein:
Function:
Antiviral effector protein expressed downstream of Sting and Rel (Relish) signaling in response to viral infection.
Miscellaneous:
MISCELLANEOUS: Was named Nazo, after the Japanese name 'enigma'.
Sequence:
MDSAISEIINALAILADDKNIQLTIKEAGKGAAICAGAALIGGLLLGPRGLALGGAIGGLTAYGLTEGNFKSLSEVILNDLTESQRRELEQHVIRAISEVRNVRVRDVARLILNNRHVQEVALEAVKSYITDRMGMTIVD
The following text describes a protein:
Function:
Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.
Sequence:
MKIVTYNQLQEAFRDYSPRDFAISRDNVFRVMRIYYNENVGQLVAFCNTQLAGRLAQFYFTIKMDLYSYKQCYNSHIFATCRNRCSSYNTFVAPGVKNVYMDKINVIKFKRNGSSFGEKAAALDKFLHNANRVHMQTPVIEGTYMRFRRAQRCRNNCVTDDARPFELERFADDFQVVNPATLTTKIEPVMACFDIETHSDGHNSSKPECDVIMCIGLAVLKDNRYDKICFVYHKELVEISGNDEYTHVVVFNNESHMIASFFDFFKYANPDVILDYNGDVFDLPYIRGRLKGDKPLLGRYDLPALQPNTKLFITKIGNRTDTYYFNYYIHIDLYKYFGADANKRDVENFELNTLSQYYLNDNKVDLNWQTMVAMYNNKQLGTMIDYNLKDCLLPIRLFNKLKLNDFMYSQCLMYRLCTDDFICNISHLISSTFFHLALTNTRTDPVTGLVVHDPYFFNKDDLGRMSSKDAGFCAGMSRLQRKRIPLKDLPANSIRLGAINEIVNYEGGKVLQPRAGVYEFAFSLDFNSLYLTIMIDICACLTNLILCEDGNVYLNQDKQAINVQLLLQLLKQRSELKKCRDSQTDSEFLYDLYDQMQNLSKRTANSIYGYYGIFCKLLANYITRVGREKLTAAIGMIEGLSNDAELLSKFNLSTLTFRVLYGDTDSTFVLPTFKRDEIPEESCMVTLTRICAAVETRVNGLFANGYKMAFENLMSVLILLKKKKYCYINSANKIVFKGWLVKKDMPVFMRVAFRTAIEQVLRHQDLQKCLDSLLINMLMYFDAFGTTKPLTDYSFSMTYNDGAGKVTENESRPTKRRVVTVARHCREILLNKGTDFVPGNGDRIPYVLLDIQGSVTQKAYPLRLFDPRTMRISWLKHMTILNTFMNELLEIFGDEHTSALNKCYDAILTKYMQHQAYDKKRVTLIKINAAYKRKAPSDDAARKRARAGPSALRKQKAASNDEDSSDEDDEDCSQAIGSNNTFKFSLYKYK