lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
Subcellular Localization:
Nucleus.
Domain:
The JmjC domain mediates the demethylation activity.
Sequence:
MTAVAASSRVSDPLAASSSAHPRTLRSSPRKRTTSHDSSISPSAAQSKQLPRRKKPRTELVDESELDCAACPAVGQPAPTPGKGAASDRETWICCTHCKTWFHCICIGLENPDDFSKWYCQPCITRSEQTFESGTSSSHPPFANVVRPPRRKSERAKLQIDYAAIQEGIPADPLGRWKNLLNAYEFEPDQFRRMQGHEWTFDWLLHDESALKQPVLVPAPPDRSSQAPHVQAKAEDVAASPVPRPKPARAKKQATHRLVPCHTSIPGMVVPPPEMSIFDVADIIGHDTPVEVIDVASQSSSKASWTISEWAEYFNTPKEKKKKTLNVISLEVTGTPMQAYVEAPQLVRDLDWVTRDWPAERRDASCSENSWPKVQRYVLMGVEGAYSDWHIDFAGSSVYYHVIWGQKTFLFAPPTARNLAAYKAWCSSTRQDFDWLGDHLHSLTRVDIGPGETMLIPSGWLHCVYTPKNTLVVGGNFLTDWNVATQWKLVEIEEATKVPRKFRFPHLKRLSWFVAKGWNDRLEPLAEFETLTKEEDQVLEESAQVSAQVDVGSLTEVVPPLKVLNNIELVLQSLSDDLELIQDPYVAESGDERKVKQQKAAREAIPTHHVGNIQKAEAMLASLRQRVDRAKSLADAVQSERVCLTWEATRAKKAKAANGSAIKSRKARR
The following text describes a protein:
Function:
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Sequence:
MALHSIEEIIEDIRQGKMVILMDDEDRENEGDLILAAEMVTPEAINFMAKYGRGLICQTMTKARCQQLNLPLMVTNNNAQFSTNFTVSIEAAEGVTTGISAHDRAVTVKAAVAKDAKASDLVQPGHIFPLMAQDGGVLTRAGHTEAGCDLARLAGLEPSGVIVEILNEDGTMARRPDLEIFSEKHGIKIGTIAALIEYRNTKETTVVREAKCKLPTRFGEFDMVTFRDTIDNQLHFALVKGEVKPDCLVRVHLQNTFNDLLHSERDQQRSWPLEKAMARISAEGGVLVLLGNQEHSSEILAKVKAFEAEDQGQTPVSAKWQGTSRRVGVGSQILASLGVTKMRLLSSPKRYHSLSGFGLEVTECVAE
The following text describes a protein:
Function:
Binds to the signaling molecule autoinducer 2 (AI-2), a furanosyl borate diester, (3a-methyl-5,6-dihydrofuro-[2,3d][1,3,2]dioxaborole-2,2,6,6a-tetraol). This complex then interacts with the LuxQ sensor protein (By similarity).
Subcellular Localization:
Periplasm.
Sequence:
MKRKLISPLFLIAALFSSTGQADSLKGYWHYDEFLAEFPEQRPISELFAQTVRDKPSALTVAQEQPVIISVVYPGQQISDYWVRNIKAFEKRMDALGIRYQINQVFTRPNLDTRQQSVSLMEALKNKSDYLIFTLDTTRHRKFIEHVLHSSETKLILQNITTPVKDWQGKQPMMYIGFDHEYGAQLLAQYYQAHAPKKPYSVLYFSEGYISEARGDTFIQDMNAVHHFPLASSYYTKATEQSGYEATLNIVKNNPEIGFIYACATDVALGAAQALKELNRQDILVNGWGGGSAELEALAKGELDVTVMRMNDDTGVAMAEAIKWDLEGKSVPLVYSGDFEVVTKQDSAARIAELKARAFRYSDR
The following text describes a protein:
Function:
Probably involved in glucitol uptake.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWVAFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNVNHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSSIPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRYKHIISELEQRSAR
The following text describes a protein:
Function:
Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MARRRSTRRALVETPSDLNAQDSDSLSVSTKEELGDDALAAEEGQSVLDEQEIEEALEEDDTNYEEDIIDDEESAQVDEEELEEEEEEEEDATPEPVVTSKKNSRSKPKNGGASKRKASRRTVVDEDSENLEGDEEDGSFSDLKDLYSNPMPAQTTPVSMRMTKRQRAIQGILEEGEEDELLELPPETSGRKKLTPEEMALRRIENARRRKNQSERRLEEEKMETINRLLKRQSNTGKPRRGRAPNNPTSDSISRSKAVPKDRINMYQPFQCVRFKSTKEGSSLGVPEPLIRFFS
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MLSSHLLNNIHRSVRATVHSRNIGILAPCLQKASDPIQQLFIEKIKEYKQKSGGGTKLVEPSPEIERELKSELEKVAKVYGGGPGVDMTKFPTFKFTDPVIDPINLEK
The following text describes a protein:
Function:
Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Domain:
The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
Sequence:
MRNPGGSLPHTLPRALQHAGRTGVVEQPGRWAPERTAGGDRSEDRLPRGGGASAAAAAAAAAASGALLGAYLERHGLPAASDLPAPAGALAGGPGSGGGVVVGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLQHLLLWVESLDSLLGVLLFVVGFIVVSFPCGWGYIVLNVAAGYLYGFVLGMGLMVVGVLIGTFIAHVVCKRLLTAWVAARIQNSDKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDVPLPSYLMASSAGLLPTQLLNSYLGTTLRTMEDVIAEQSLSGYFVFCLQIVISIGLMFYVVHRAQVELNAAIVACEMELKTSLVKGNQSDPSGSSFYNKRTLTFSGGGINIV
The following text describes a protein:
Function:
Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.
Subcellular Localization:
[Isoform 1]: Endosome membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Note=Localizes to nascent focal adhesions; [Isoform 2]: Membrane; Single-pass type I membrane protein; [Isoform 3]: Secreted.
Sequence:
MKPMLKDFSNLLLVVLCDYVLGEAEYLLLREPGHVALSNDTVYVDFQYFDGANGTLRNVSVLLLEANTNQTVTTKYLLTNQSQGTLKFECFYFKEAGDYWFTMTPEATDNSTPFPWWEKSAFLKVEWPVFHVDLNRSAKAAEGTFQVGLFTSQPLCPFPVDKPNIVVDVIFTNSLPEARRNSRQPLEIRTSKRTELAQGQWVEFGCAPLGPEAYVTVVLKLLGRDSVITSTGPIDLAQKFGYKLVMVPELTCESGVEVTVLPPPCTFVQGVVTVFKEAPRYPGKRTIHLAENSLPLGERRTIFNCTLFDMGKNKYCFDFGISSRSHFSAKEECMLIQRNTETWGLWQPWSQCSATCGDGVRERRRVCLTSFPSSPVCPGMSLEASLCSLEECAAFQPSSPSPLQPQGPVKSNNIVTVTGISLCLFIIIATVLITLWRRFGRPAKCSTPARHNSIHSPSFRKNSDEENICELSEQRGSFSDGGDGPTGSPGDTGIPLTYRRSGPVPPEDDASGSESFQSNAQKIIPPLFSYRLAQQQLKEMKKKGLTETTKVYHVSQSPLTDTAIDAAPSAPLDLESPEEAAANKFRIKSPFPEQPAVSAGERPPSRLDLNVTQASCAISPSQTLIRKSQARHVGSRGGPSERSHARNAHFRRTASFHEARQARPFRERSMSTLTPRQAPAYSSRTRTCEQAEDRFRPQSRGAHLFPEKLEHFQEASGTRGPLNPLPKSYTLGQPLRKPDLGDHQAGLVAGIERTEPHRARRGPSPSHKSVSRKQSSPISPKDNYQRVSSLSPSQCRKDKCQSFPTHPEFAFYDNTSFGLTEAEQRMLDLPGYFGSNEEDETTSTLSVEKLVI
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Domain:
The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA; The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.
Sequence:
MSQQQMPVALDPLDFPLHGSRLIEASAGTGKTFTIALLYVRLVLDHGGENAFGRPLSPPEILVVTFTDAATQELRERIRSRLGEAARCFAEPQERHDGLLVALRQQYPTERWPGCARLLRLAAEWMDEAAVSTIHSWCYRMLREHAFDSGSLFTQNLETDQSELLAEVVRDYWRRNFYGLTAPAAQAVASCYSGPEALGKALQPLLARQDADFRYADQALSAPESLAALLEQGGDWYRQLDQLDAQARAAWRAARVELEALLRDLRPYLNGNSYRGKDSDETFDAWLQALADWSEGGEQPANLGKFGQTRIKLTAKRVAPEHAALRAIDAWAAHQEERPDLAPHLLLHALGEVGHELEIEKQRRAEIGFDDLLSRLDRALQGPGGERLAQLIREQFPVALIDEFQDTDPVQYRIFERIYRIAADPDEPQARETGLFMIGDPKQAIYAFRGADIHTYLRAREATRGRHYTLGKNFRSTAAMVAAANRCFAFAEEHPRGAFRFAREGLENPVPFHAVDAQGRAERLLIDGAEAPAMTFWNLDVEAGVLGSAAYRQEMAERSASAIRRWLSLADLGRAGFADEQGGWRALRPADIAILVRGRAEAEAIRSALAARRLASVYLSDRDSVFDSQEAADLLHWLRACADPGADALLRVALATRSLHLDWATLERLNQDELFWERMVLRFRDYRRSWQAQGVLPMLRRLLADFELPARLLRHADGERSLTNLLHLAEWLQRAAVELDGEHALIRHLAEQVQSPGSEEILRLESDADLIKVVTIHKSKGLEYPLVLLPFICSWRELDGNSGAPASFHEDGAAGRVIELARRKEQAARAYEQANDERLGEDMRLLYVALTRARHSVWLGIAPLVASNSKSPELHKGALGYLLAGGATIGSDGLGQCLAALRGECREIVVEPAPEADAERYVAGRGQGLGQARETRRSSREKWWVASYSGLQLQASAGLDDDEVLESDESQEPISAEEATFHEEGRSAEQPPVAHASEMRDDLHRFPRGPAPGTFLHGLLEWAGREGFDVARADAQRRRELVARRCDLRGWKDWAEPLDLWLEQYLAEPLRWPGGETSLAGLVAYQVEMEFWFATHQVQAEAIDALVRRHTLGGAARPALAPTLLNGMFKGFVDLVFEHQGRFYVADYKSNWLGADDGAYSPEAMTAAVLENRYDLQYVLYLLALHRQLKARLPDYDYDRHMGGAVYLFLRGTRAATQGLHFERPPRELIERLDALFSGQPGAER
The following text describes a protein:
Function:
Putative adapter protein.
Sequence:
MPSTPYDLVQDDQDLRVPLHAEQAFFHGITFQAKFVGWEEVPRPNTRAEIVQAMRRIRYECKVQNLKKRKVTIHISVNGVRVVLKKRRRKKKNWTNDPEDIELLNHPIYRIFYVSHDSSDLKIFSYIARDASTDTFKCSVFKSHKKSQAMRIVRTVGQAFEVCHKFNLHKNSLEPNDERSDISSSELLDVEQISEQQLSEDGERGGGDNETPKKEHLAITPDLNHTQPQRPNHLDIMPSHSSLRKSNSLLCDVDDKSPGSPSSPRSEITQLKDQLEAQALQTRQALGQLMLVREQLISETNARIEAQARTQQLLQQNRELLEHLASLGAYNEQQTAGLTSANIGMAPQQSQLQMLLQATSNNNNLATINQQISNLGSINQQLTSLSHQLSGLNQQSQHLQNLQQQQQQQQQQQQQQTQAAPTAATPPPAAGGSSPYPSMSALQSISNQLQQQQQQQQQDALSKDLFQVNQELLNRLQALNLNANPGQSQPTPSATAHNSFFYVNPLSCTPATPNNNAGGAGGFNFLTSPAATGTLTPSPLGTMNRNSFAGSSSLNEDIRLSIEQNLNNLEEQLKAAVSNGNLAGLACGGSTSTRDTSRSSSTLDSPSSPRLRSSNNNISPGSSNGNQNHNNNSNSNSSSSRETRFNTVLLRVTDEAGHQRKLSATPSFITRSTSEKVPNRSQMMSQVQRTTWARHTTK
The following text describes a protein:
Function:
Involved in endoplasmic reticulum to Golgi transport. Involved in a protein-transport step blocked by brefeldin A, which disrupts the Golgi apparatus and its incoming protein flux. May also be involved for mass growth or cell proliferation.
Miscellaneous:
MISCELLANEOUS: Present with 15400 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEKSLADQISDIAIKPVNKDFDIEDEENASLFQHNEKNGESDLSDYGNSNTEETKKAHYLEVEKSKLRAEKGLELNDPKYTGVKGSRQALYEEVSENEDEEEEEEEEEEKEEDALSFRTDSEDEEVEIDEEESDADGGETEEAQQKRHALSKLIQQETKQAINKLSQSVQRDASKGYSILQQTKLFDNIIDLRIKLQKAVIAANKLPLTTESWEEAKMDDSEETKRLLKENEKLFNNLFNRLINFRIKFQLGDHITQNEEVAKHKLSKKRSLKELYQETNSLDSELKEYRTAVLNKWSTKVSSASGNAALSSNKFKAINLPADVQVENQLSDMSRLMKRTKLNRRNITPLYFQKDCANGRLPELISPVVKDSVDDNENSDDGLDIPKNYDPRRKDNNAIDITENPYVFDDEDFYRVLLNDLIDKKISNAHNSESAAITITSTNARSNNKLKKNIDTKASKGRKLNYSVQDPIANYEAPITSGYKWSDDQIDEFFAGLLGQRVNFNENEDEEQHARIENDEELEAVKNDDIQIFG
The following text describes a protein:
Function:
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Sequence:
MNQNSNQLLGQPKNQFKIVESVYQQQQPQQQQQQQPRQQQSVSSKPVEESHCIRVRSKEVKAVHRMMLWFSGKKQQKLYQKMKKKHRYRKNVIAEIINTERTYVNDLAIICEKVKTSSLSILSPNDVQTIFMNCDEILAWNKEFLQEMEKGYSKYNLDKNQMPRPYQSVFYGNAQQLKTPDLVAFKCYYEYCSKFTKSNKHFEHLKANDQKFKEFLTQLNKNNTLRGMDLGSFLVKPIQRLPKYILLFKDLEKNTDEDYPDLPNIKEIHKYFKEVNEENNKFMDIFMGRLQLQQLSESLKINQEELLNEPQRIFKFEEKLTTIQPNAKHDEDCQVTVYALSDMLVVVQDEKVQKKLKLDSLSFVKNQSDNNKYFSNLFQIVGVGDTIQCIAETPAAKKKYIDLFEKLIQENREHEHEREKELGNQQIKMRYPVQVVVVGTEERNFQSFTKHTQYITEISINKVFQNIFIRYSEIEVMSIKYKQRYPRIELPQLPDKNWLMSHKTKSIEARKIAIENFLQALLQAKESQSDPDILNELKLPKNFFDLPDLYQSILKSNLTQKQQNFKRTTLEGKEELREKGINIEKLKISAGEILKAVYIEQETRKKSVVQICPNKVISYENSKDPSLQKIIITFPDGTETALGVTEQTRVREVLEYVAKYNHLVYYKDFRLYLVDQLKKQRVLDDDEVLFKVIDDERQNNHGILNKLEQMLAKSNAEVLIKMKKYIYLPAKLEESDYKEDPVRLINLAFSILDDVHDQKLQLGFKEYCLFAALYFHMKHQRLDDKLFGEVRRVIPSEMFQSSTDKEWKDLVTQCFKALDNELSTISKKNENDQIQKKPNSQYKHTDKKYLAAGVTLNAARTFVQSIMAIFQVQVYEGTQKYFKNLGLEVHPTIYLGLSIHKIHFLNPQRKEQFREIDYSRVNGVKSYPSQIIFDLQIFKEPIRFDTYQSYEIKSLVEQYQAIQKFDEEYELGHQFNIKH
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the export of sodium and potassium from the cell. May be an inefficient potassium exporter. May transport other cations such as lithium (By similarity). Sodium/potassium efflux ATPases are involved in salt tolerance and maintaining the membrane potential across the plasma membrane in high salinity (Na+) or alkaline (K+) environments.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTPSIGYVDEDENGQKSKFLRSSDDPYRLSIEEVIEKFETHLENGLSDEQAKSKLAKVGLNNLGADEKISISKILAHQIFNAMVLVLIISLIIALAIKDWISGGVIGFVVFINIFVGFIQELKAEKTMGSLRSLSSPMARALRNGVDSNINAEEVVPGDIIHIKVGDTIPADLRLVDCMNLETDEALLTGESLPVAKDHEEIYDYGAPIPVGDRLNMAFSSSIVAKGRGTGIVVATGLDTEIGKIAKSLKNNDDAVVVKVDKSLNPSTKDYLIAVIKTTKNIIFNVLGTNVGTPLQRKLSWLAILLFWVAVLFAIVVMASQEMRVNRNVAIYAICVALSMIPSSLVVVLTITMAIGAQVMVTKNVIVRKLDSLEALGGINDICSDKTGTLTMGKMIARKVWIPNVGSYLVQNSNEPFNPTVGDISFNENSPKFIKETDDELDFIPHLPSPTPILFEKWLHIATLANIASLNQIQNEMDGSIEWEAHGDATEIAINVFTTRLGYTRDKLIGDSLEHLNEFPFDSSIKRMSTVYKDKDGNSTVYTKGAVERVLSCCKYWYNPELTALSEEDKLLIESNMNALSSEGLRVLAFAQREINISKENVSNREVVESNLIFLGLIGIYDPPRPESAKSVKLCHKAGINVHMLTGDHPGTAKAIAQEVGILPHNLYHYREEVVKVMVMIANEFDSLSDDEIDNLPVLPLVIARCAPQTKVRMIEALHRRGKFVAMTGDGVNDSPSLKKADVGIAMGLNGSDVAKDASDIVLTDDNFASILNAIEEGRRMSSNIQKFVLQLLAENVAQALYLMIGLAFIDKSGYSVFPLSPVEVLWIIVVTSCFPAMGLGQEKASHDILEQPPNATIFTWEVIIDMIAYGFWMAVCCLVCFVCIVYGKGDGSLGENCNEGSDTGCNLVFRGRSGAFAAFTWCALLLAWECIHLRLSFFKMRPELENPWWKQLAIDLWDNQFLFWSVMGAIVSVFPVVYIPVINNKVFLHAPIGYEWGLAVAFTILFLIGAEGWKWFKRVYYRKSNANNPEYDLERNDPFKEYSSFSKSNTMEIV
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Subcellular Localization:
Mitochondrion.
Sequence:
MQALRALQRSGLQKAVAAASSSSSTLSHRSFHSSRRALEFSKFNMPAMSPTMTEGGIAAWKKQPGEAFSAGDVLLEIETDKATMDVEAQDDGVLAKILVGDGAKAVQVNSLIAIMAEEGDDLSGADAFAAKASSEGGEAKPAAKEEPKEEPKEEPKEESKPKDEPKQQESTPSSSSSSSSSSSFGSQSSGDRIFATPVARRLAQDKGIALNKIKGTGPEGRIIKADVENYKPEAAVAAPAASSAAPAKSAGAPAPAPAASEGGDYTDIPVSNMRRTIAARLTESKSSIPHYYVSIDVEMDKVLKLREVFNKAAAEKAGKDVEKAKAAKLSVGDFITKAAGVALKEVPEVNSAWYGDFIRQHNKADISIAVSTPTGLITPIVKDVGGSGLATISAATKSLAAKARAGKLAPQEYQGGSFTISNMGMFGITHFTAIINPPQSCILAIGGTEARLVPDAESEQGFRKAMIMQATISADHRTVDGATAAKWMKAFKDALENPLSFML
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MIGFPYESQSNDKTIKFPLLIIYTASEVWIAEHERDSRASSQITNTLGGSQCKIILQPYLHESRHLHALKRARGCGGRFLTAKETDNQQKQDETGDKSQVNINLESGKDKIDRNRPTRLRATKWPLGIFLHIL
The following text describes a protein:
Function:
Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins (By similarity). Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity). Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle axis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDNGHGYEEFELLEDGSLGECSTQVANATFLTISKLICLVVAFKFIKHIPISTTVRVYVHVFASTFTVMWFSRNHLQSAIIYNMFSLISLALAIKQFSGYIILAGNISLLIALQNFCRHYRSEDYFLSIRGILMIHIMRLTTVAFNLEKANSNKFRFVQFSSYVEYIYFPPFIIFGPYLSFEQFFKMRDKKWTGSENELGFIIQSLLAIFNAITLAIISSCHFEFFEPSSQFMEDALTAMSFRFSHYFVCLSTQAFVLMLGSDVVVANPLNIEFSRSTLQTVSEWNKPFHTFLHENIFKRRLFNSTACNVFFTFAVSSLLHGLDFQMTITLLALGFIAYSETVFRKRLSARYSMCVAAKACPVRSNSLSCKHRHSNKTGRALIINLFFLMLSMYHLVFTGMTFTDDYSAIGYPFDHAWKIWGSHYYSSFMISFLFLALSKII
The following text describes a protein:
Function:
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.
Sequence:
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
The following text describes a protein:
Function:
Regulates export of the secretory proteins from the endoplasmic reticulum in COPII-coated vesicles.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.
Sequence:
MMSFGSFVYIACLLLNGANMLLQIFCVIMFSDLEMDYINPIDLCNKLNDLVMPEIISHTLVTLLLLLGKKWLLFLANLPLLVFHANQVIHKTHILDATEIFRQLGRHKRDNFIKVTFYLIMFFTLLYCMVMSLIQEE
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVAWGGMTFYGTALIGLNALALWDLYLQRRQRKAYANAKMPEHLVGVVEEKEFRTTQEYEREKLSFSILLHVKDIVISNVSLLAKLPAKLYGSLGQLLPGATGSFSHCYVYAVATDVLTTLISLPFEYYSTFVIEEKHGFNKMTRKEFFLDVAKYFLLRLTLLHVLTSGLILKVVELFGEDFPFYFFLGATGLITIFTFVYPTFIQPLFNTYTPIPKDGELGKKIYALAEKHKFPLKKLYEVDGSRRSGHSNAYFYGFWSKHIVLYDTIVEQTKDDHDALLAVLCHELGHWKNSHDKFFFGFMVAQTWCISYGAKAVIFNTDLYKQFGFSDANPLIGFELFSQVFLEPINTLLGYLVSLVTRQFEFQADRYAVSSGYGEPLIRGLMVIHKENKNLLTPDPLFAALHYSHPPLAQRLDAIKEENKKRK
The following text describes a protein:
Function:
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MCPGLPPCQALRAVPGSQGEGKPKPVKRSSNQDGVNEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPDFRVTTFVNHPQVSVLLEEEVEEALLYLTRVEVTEFEDIKSGYRVDFYFDENPYFENKVLSKEFHLNENDDLSSKFTEIKWKSGKDLTKRSSQTQNKASRKRQREEPESFTWLTDRSDAGADELREVIKDGIWSNSLQYYLVPDMDDEEGEAEDDDDDEEEEGLENTDEEGDEDEGEEDDDEDEGEDEAPAPTVTDLNAIYSLMKGQLLVCLHWQCELTKKVGCQAHHPPKVVEKKGYPESGPVYKWFFGASPICVVWKFGSSVHSLSVVVPFTQKLHGHIYNSQKLERTQMPSTEEWIQKMGHIYTMEYYSTTENNNFRKFLGKWMELENIILSEPPNPVTIAEAKKCLLTGTWYGCFLRGSSRALLIQVRMVAANHWTEQGDPNAGVREKMEGAEGVCNTIGRTTMPTNQIPPELPGTKPATDEYTWKDT
The following text describes a protein:
Function:
Cleavage of the 16 C-terminal residues from the D1 precursor of photosystem II (PSII). This proteolytic processing is necessary to allow the light-driven assembly of the oxygen-evolving cluster (a tetranuclear manganese), which is responsible for photosynthetic water oxidation.
Subcellular Localization:
Cellular thylakoid lumen.
Sequence:
MLKQKRSLILGTTALLLTTVAVTGVGLRLARSQGYLQDNPKELVDEVWQIVNRTYVDGTFNGEDWVAVRQDYLTRDYKNQEEAYTAIREMLEKLNDPYTRFMSPDEFQSMRIDTSGELTGVGIQITQDQDTKKIVVVAPIEDTPAYNAGILSKDVITKIDGKSTDGMEVDDAVKLIRGKPGTSVVLTIEREGQAIEYPLTRTLIEIHPVRAQVEDINGARVGYIRLNQFSAQASEEMRQAVQKLEKENVVGYIFDLRSNPGGLLYSSVDIARIWLDEGGIVSTVDRRGEVEQQSANKRQLSNRPLVVLVDGGSASASEIVSGALQDNQRAVIVGTKTFGKGLVQSVRELGDGSGMAVTIAKYLTPNGRDINKHGIDPDVEVELTDAQRKELQQNREKVGTLEDPQFARAYEVLMQQVNKTASK
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWYAICNLLVVLSFFLSTYLTLRQRKTILRATEPPKIFKDKITDEKFQKEKAYQTDKINFALLQSVISFFLVLFKVKFIGTFWNFFNYGGEIIHSLIFLDVFDVIGTIIDLPFSYYSTFVIEEKYGFNKSTKKLWVTDILKSQAISLILTDILVPIIIFIFRKAGAKSVYIIQIVLVIIQLIMQVIYPILILPLFTKLTRITEGPAFEGINKLCEETKFNAKEVYSADDSKRTNHTNAMVFGLFTKKIAFADKFLEDPKVDQLVAIIAHEIGHSKHWHIFKQFIISQIQFAIFFNVLYMFMSTDSIFIEFGVEDKPFIIGMFLFGILMSPIETLLDLPMNMLSRHFEYQADSFAAERNLPIDLALIDLATDNMDTIDDDPLYSAFTSSHPTIPQRVEAARAIMKKKE
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant.
Miscellaneous:
MISCELLANEOUS: ThyX activity is mechanistically distinct from ThyA activity.
Sequence:
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDKELIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRIASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDNEKVNAMSVLALENLRILLSEHNIKNDLAKYAMPESYKTHLAYSINARSLQNFLTLRSSNKALKEMQDLAKALFDALPGEHQYLFEDCLKH
The following text describes a protein:
Function:
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKMASFLAFLLLNFRVCLLLLQLLMPHSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVADGVGLYAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAGTLPVLLLLLGGAGYFLWQQQEEKKTQFRKKKREQELREMAWSTMKQEQSTRVKLLEELRWRSIQYASRGERHSAYNEWKKALFKPADVILDPKTANPILLVSEDQRSVQRAKEPQDLPDNPERFNWHYCVLGCESFISGRHYWEVEVGDRKEWHIGVCSKNVQRKGWVKMTPENGFWTMGLTDGNKYRTLTEPRTNLKLPKPPKKVGVFLDYETGDISFYNAVDGSHIHTFLDVSFSEALYPVFRILTLEPTALTICPA
The following text describes a protein:
Function:
Part of a signaling pathway. Required for initiation of medial ring constriction and septation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm.
Sequence:
MNRVNDMSPVEGDLGLQLSSEADKKFDAYMKRHGLFEPGNLSNNDKERNLEDQFNSMKLSPVASSKENYPDNHMHSKHISKLPIASPIPRGLDRSGELSYKDNNHWSDRSSTGSPRWENGSMNLSVEEMEKVVQPKVKRMATICQMFFLDHYFEQLHYLYTRKQRARLFEEQLLKEPDSRRDELVKRYNGRERVYLRKRRTRISHGDFQTITQVGQGGYGSVWLARKRDTKEIVALKIMNKSVLHKMDEIRHVLTERDILTTANSEWLVRLLYAFQDTSNIYLAMEFVPGGDFRTLLSNSGVLRDHHAKFYATEMFLAIDALHQLGYIHRDLKPENFLVGASGHIKLTDFGLSSGIISKKKIESMKIRLQEVNNVVVPERSMRERRQVFRTLLSQDPVYAHSVVGSPDYMAPEVLRGENYNHSVDYWSLGCIMYECLSGFPPFSGSNVNETWSNLKNWRKCFQRPHYDDPRDLEFNWRDDAWDFVCHCITDPKDRFCSLKQVMQHPYFSKIDWKNVRTAYRPPFVPDLNSEIDAGYFDDFTNENDMSKYKEVHEKQAAIANMVNTFNKPKRNAFIGFTFRHQKNSHPTSSSSALSSPLSAPSFGTLL
The following text describes a protein:
Function:
Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
Sequence:
MLSKIKDSINSLRGITEKKLEKKDGTKYIMFGGKGGVGKTTMSAATGVYLAEKGLKVVIVSTDPAHSLRDIFEQEFGHEPTKVKGYDNLYVVEIDPQKAMEEYKEKLKAQIEENPFLGEMLEDQLEMAALSPGTDESAAFDVFLKYMDSNEFDVVIFDTAPTGHTLRFLGMPEVMDKYMTKLIKLRKQMSGFMKMMKKLLPFGGKDEDIDYDKMLEELEKMKERIVRARNILSDPERTAFRLVVIPEEMSILESERAMKALQKYGIPIDAVIVNQLIPEDVQCDFCRARRELQLKRLEMIKEKFGDKVIAYVPLLRTEAKGIETLKQIAKILYGEEEKEEQKIEQKVGQ