lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds GTP and exhibits intrinsic GTPase activity (By similarity). Involved in the regulation of arginine and lysine uptake. Acts through the CAN1 permease.
Miscellaneous:
MISCELLANEOUS: Present with 1600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Cell periphery, adjacent to the plasma membrane.
Sequence:
MEYATMSSSNSTHNFQRKIALIGARNVGKTTLTVRFVESRFVESYYPTIENEFTRIIPYKSHDCTLEILDTAGQDEVSLLNIKSLTGVRGIILCYSIINRASFDLIPILWDKLVDQLGKDNLPVILVGTKADLGRSTKGVKRCVTKAEGEKLASTIGSQDKRNQAAFIECSAELDYNVEETFMLLLKQMERVEGTLGLDAENNNKCSIM
The following text describes a protein:
Function:
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs).
Subcellular Localization:
Endosome. Prevacuolar compartment.
Sequence:
MAPPPAKMQEIHQFLSSALTQRGPSALPYAENTKSLIRQHLLNLISSYTSLDPKTATFTHNDGRSVILLQADGTIPMPFQGVSYNIPVVIWLLESYPQYPPCVYVNPTRDMIIKRPHSNVSPSGLVSLPYLQNWIYPSSNLVDLASHLSAAFSRDPPLYSQRRPPPQPSPSIGSGYSRPLPPRQTDDAAEVYKKNAINRIVEMVHGDIVLMRSAREVETEGLLSLQSDLKRREEEINNGFKEMVIEKETLEQQLQVIAMNTDVLGSWIRENQGKAKDLLVDLDVDDSFECIDSLSKQMLECTALDLAIEDVVYSMDKSFRDGSLPFDQYLRNVRLLSREQFFHRATAEKVREIQMDAQVASIAARLHS
The following text describes a protein:
Function:
Decoration protein that binds asymmetrically to the center of each capsid protein hexamer after capsid expansion. Stabilizes the capsid and protects from DNA release.
Subcellular Localization:
Virion. Note=120 copies of the decoration protein are localized on the exterior of the capsid.
Domain:
The N-terminus binds to the capsid proteins with high affinity and high cooperativity while the C-terminus displays an IG-like fold.
Sequence:
MIDYSGLRTIFGEKLPESHIFFATVAAHKYVPSYAFLRRELGLSSAHTNRKVWKKFVEAYGKAIPPAPPAPPLTLSKDLTASMSVEEGAALTLSVTATGGTGPYTYAWTKDGSPIPDASGATYTKPTAAAEDAGSYKVTVTDSKQVSKDSTTCAVTVNPTVPGG
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
Subcellular Localization:
Nucleus.
Sequence:
MTGSQRQGPHRSNTNTSEHSLGRIQQHQSLNNTANNISESTFINNSQLASSLAYPNPLLGLSQFRDRPDSRQQMQSAMLDDSDVTAISTASQRNPYPMTGSAQRLRQMPQFQPMLQSGVQQHIQLSQSGSSVSMQAAHAPQLNPKLQPQILQPQLLQHIQQQQFLQQQQHQNLFQQQHQEPSQQHLKRFQKQNITPPLFVSDSSVHGLKPLHKYEYRLPSDRLLSRSGGSDYVDVYLQRHGQPEDKLDETTVKAGYTDKSPVQNETLSVFESIHIYDHLSRKNVFQDMVKFASTVLAAQSQVTFPKESQFTISRRTGTSSKTYDNWIDDLFGNIPFSELSKSVPFGLKLDKLLESLQQKQVSLVRATWAIKMIGVTDLASSSRLSRVDSHLDASFSWTSIVIAYIQKQINEVSLSAVNTPQISQVRNQKRTQSKEAIAAAAEAAASKHISPKQRHHFISRWDYLMRLCAKQYEEGLLDQGSFLKKSLEIFKMCNFSQTMFAVTLISMFVLEIGRSRALMRLLVSICLKKLKKLKLHISTSDFAKEQYNQLVILLQRGYRCAPDTFVSTKLWVNFEEFLTVVFADEHQTRMEVESRNNWLISSAPLTLCASESLNVLFRTLGYWTNYSQIYQTWDAFFDGFTDISIHLRHIFNWALADSRPSQDSRAFIAARLVSEWYKNMLNDNLTKKNHHSLLSMNFAKLFYKLLDKLIATLPSGQDEQHRLFLLFSQLEQLRVFSIRQYAQRLVSRGDLDSSSNTSEKFKCFLQGYPLRIAELVQNCQLYHKNDVNLANDSDNDFCIQSVLELIVRTDTESRKQDVLHFENIKKQIIAVLPRIYISGDKVDTLRDRLVQDMPKDRALAWPNMKLKQNLISLVPIWRIRLSIWLKKCVVQFIVKAQEIGINNWKTVSTPGNSTLNDRQLATVIWILETLRDYPSLLEILMWLINKTTERNIYRSIVFALERHQLVFHAMGCSQLIFDHLFEKHQTLRKRGTGLDPHILRHLFSLLTHKLCEMDFEERKKLESDRALPLKRGTSKEIPLEFRDLRDAKDDRQSITNAASSLIWRFQDMREALARLFKYSLILLSRQSSIMQKDDFRRRVTLTVEVLREVADRNPSLQASIIDHYRDTYVTSKPFTVMTPGTELLGGIDNMASTWSISMIVQLITSRCCPLQRFLDEVVDPIISRAKANIDLLKSVYFTNLISNMVYLLSVICISTESVSLTPQLILTLQQYQYLERLRVVDMHTPAYLSRILHILQSLAFIRSRLTSTSAAVDIASNEQLLSGIQVLLTYVLERPGWFKHACITDQSWISFDLARLFTDAKNLFSQDTLALDMVLQSTHVVFKALWDTHTFDGYTENTVEAPFNINAFETCFERICRHSNACNRDRCQYLLTLTLELLHLHQSIHASGVTAVSSFSQSVSVDSIAASRQNMAEAYSKCWDRLVDVCFKEVLGRNSTSLSHLLPKMRWEFLKRLVVRSQQLMESVHSLLSTTPLKEFNLAGTNIALDADSQQHLVVNTASIKCFGEFTSKLGVYMCHRLKEVRKAKSSGKTAAKQTEDAYLADISVLAAFILRDLLWFQENIKVFDLMVDNEISFGKAHQLSTAVSSTDLPPSQLQDQVMLAQIQEILIARLTLVKTLAPVIMENPIRFQIVLLAQSLMKLLVSKLVTNTIGTSHLFQITLDVVSWFMEEIPKDLSKGLFAWLVKNRQEFSLPSPAGDRVNRILPFVDRNRLVSNLIFRSSGFNESLHELGTATSSSASSTPIWKPSQVSASVSTQSTGMSASITSPTPSASNTPHLARAPIVTSDSKHSTKPASFLKVDQHYFLPWKWLEDPGDVVLQQQPPAPSMCWANPNTIAPLNNTPISLTSFGAKVLHPMEPAYIQLHKQGWTLPDVGSRVSDNTALMELTNFSDEESVVEVVMTSSTVTAASTQPTPVAHVDMPQHTTFDAMDIDVNPNHQAGIMDVKIHSGSLKPAVTKGSRIPTKRKSTDTTTTGITKAIKKHN
The following text describes a protein:
Function:
Probably involved in the regulation of plastid gene expression.
Subcellular Localization:
Plastid, chloroplast stroma, chloroplast nucleoid. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Sequence:
MASSSTSFPLTTAPPQGVRFNRRKPRLTVWAKQTAFQLGKTKGDDDSEGKQKGKNPFQFDFGKLPDMKSLIPVVTNPSTGLVFGNNRKKDPGTIFVAGATGQAGIRIAQTLLQRGFSVRAGVPDLGAAQDLARVAATYKILSNDEVKRLNAVQSPFQDAESIAKAIGNATKVVVTVGATENGPDAQVSTSDALLVVQAAELAGVSHVAIVYDGTISGSTYNVLDGITSFFGNLFAKSQPLTISDLIEKVAQTDVAYTLIKTSLTEDFSPEKAYNVVVSAEGSNSGSGSSSSEAYKVPKLKIASLVADIFANTAVAENKVVEVSTDPSAPSRPVDELFSVIPEDGRRKVYADAIARERAEEEAKVAADKAREAAEAAKEFEKQMQKLSEKEAEAASLAEDAQQKADAVGVTVDGLFNKAKDISSGLSWNKLGSQFATAIQNASETPKVQVATVRGQAKARNLPPKKAVVKQRPSSPFASKPKEERPKKPEKEVRKVFGGLFKQETIYIDDD
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.
Sequence:
MRGVSELEVGKSNLPAESELELGLGLSLGGGAWKERGRILTAKDFPSVGSKRSAESSSHQGASPPRSSQVVGWPPIGLHRMNSLVNNQAMKAARAEEGDGEKKVVKNDELKDVSMKVNPKVQGLGFVKVNMDGVGIGRKVDMRAHSSYENLAQTLEEMFFGMTGTTCREKVKPLRLLDGSSDFVLTYEDKEGDWMLVGDVPWRMFINSVKRLRIMGTSEASGLAPRRQEQKDRQRNNPV
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MSNETEGIQDRTGILERWSRVFDNSFASSIAKTLPKTSKQPTSDTLELEDVFEEVVDEVPIARGGCRHPTESAPHQPNRRWAHQARKKSLEQVSPKIPGRSQLTGGKPAKAMQEQTPKIMPSRMKTRMEKDTEITTRAPSVTSGRPPSGRVRARVSTPPKSAKQAKPASPVKPVIPGGTLINLETAQSLRTVLFGTCGTSFNSDWRKQHINFSMNSHYGLSFYKPGPAGVLACLQAFLIKNLLYFNATPAIAKSMLQPMSSDRQRALVAALSQMMWQAGERKHAVVTLPCGEFQWLSYEGYKLDHLTENLMLFTFSDFDELQRFIKRQVTFFESTSGDGCILLLYSIILSRTTKRVTEDLSEPNSILLDSNNGCSQAMMNLLLTGRATKNVFNGDVEYNKRGTILAYPQKGIKERSEIGFLTLWEHIDSKDVEVGSKLKTPKFPVWVVDSTGGRYGVVFCLNKDLVNDWRLERRFELYYYNGTTRHSGAVGDVITVDTRDIVDENEVTEDTHPVEHCLRTKWPGAVIEWSSRYETRGSVQK
The following text describes a protein:
Function:
Malate transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGPFHQQSRERLLSQNEYSDMCFRKITNLCELGHSDRRRIFFAVKMGMALALCSVVIFLKEPLHDASKYSVWGILTVVVVFEYSVGATLVKGFNRAIGTVSAGGLALGIARLSVLSRDFEQTIIITCIFLAGFIASYSKLHPAMKPYEYAFRVFLLTFCIVLVSGNNTGDFFSTAYYRFLFIVVGATTCLVVNIFIFPIWAGEDLHKLVANNFKSVANSLEGCVNGYLQCVEYERVPSKILTYQTSDDPLYSGYRSAIQSTNQEESLLDFAIWEPPHGPYRTFNHPWKNYVKLSGAVRHCAFTVMAIHGCILSEIQAAPEKRQAFRHELQRVGNEGAKVLRLIGEKVEKMENLGPGEILNDVQRAAEELQMKIDSKSYLLVNSESWAATKEKAEAEEYEEEAHETKVIKSLSQIWDTNSSSNNQNPASGNDESQIWESTESMMLRNRETWPSVSFIGGSVVNETVYKVYESASSLSLATFASLLIEFVARLENLVNAFEELSTKADFRDPVPLNVVDQEGLWTTLMRLRRLRRYFGRS
The following text describes a protein:
Function:
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Sequence:
MLQDKSLIERSIARLRKSLSREPYNLRLCLDSPEEEAVAARLALYIAAATKNNYILKRFADSESKNFSETLRKTPGIQNLNCKIEIGKDLGIIAKPAQDVVTGIINAAFKTPVAIKWTSYLRYAPPDPFWAMINRVVVKGWVILPLDDFERILEEAYEEQILRIASENELAVGRVSASIDMSLIEDLLRKYAQRPVNITKLSTEGPDPPCMKAILDALKAGENLPHAARFAIATYLLHKGWEVEQIVDLFRTSPDFNEKITRYQVQHIAGQVGGRKEYAVPNCETMNSWGLCPTNLGCGVKNPLQYGRRVAIKKSN
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MENKRKQKDEIVLVNGSNDTTPNKKQKNELQVVSSGGGREIILGTERTSKLEHPIMQLIGHKGEIYSCKFNSYGTALASGGSDKEIFLWNVYGECINYSVLKGHKGTILELHWSTDSNEIYTACTDKSIGVWDSNKGELIKRIREHSGVVNSCCPARRGPPLVASGSDDRSARIFDTRSKGSTHLFQHKYPVTSVCFSDASDQLITGGIDNVIRVWDIRNQEDPLYTLASHQDTITSTSVSKDGAYLLSNSMDNSCKIWDIRPYAPPNRNIKTFNGAQNNFEKNLIKSSWSIDGRRIGCGSSDRQVYIWDTNTKQLQYCLPGHSGTVNEVTFHPNEPIIASCSSDKTIYLGEIKP
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAQGVTGSVTVALHPLVILNISDHWIRMRSQEGRPMQVIGALIGKQEGRNIEVMNSFELLSQINDEKITINKEYYYTKEEQFKQVFKDMEFLGWYTTGGTPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVYESVIDIVNGEATMLLAELSYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVRLILEYVRAAEGGEVPFNHEILREASALCHCLPVLSTDKFKTDFYDQCNDVGLMSYLGTITKTCNTMNQFVNKFNILYDRQGIGRRMRGLFF
The following text describes a protein:
Function:
Broad-specificity enzyme that catalyzes the transamination of 2-ketoisocaproate, p-hydroxyphenylpyruvate, and phenylpyruvate to yield leucine, tyrosine, and phenylalanine, respectively. In vitro, is able to catalyze the conversion of beta-methyl phenylpyruvate to the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin produced by Streptomyces hygroscopicus NRRL3085.
Subcellular Localization:
Cytoplasm.
Sequence:
MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLNAQPHGASLYLPMEGLNCYRHAIAPLLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLLATLKTLPARSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLSVMCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLAEVEEMRTRILAMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM
The following text describes a protein:
Function:
Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MEAPHPSLVLTSPGGGTSATPIVTSRAATPRSMRTKSHEGITNSVMPECKNPFKLMIGTSNTMGRLYVQELTGSQQQELHSAYPRQRLGSSEHGQKSPYRGSHGGLPSPASSGSQIYGDGSISPRTDPLGSPDVFTRSNTGFHGAPNSSPIHMNRTPLSPPSVMLHGSPVQSSCAMAGRTNIPLSPTLTTKSPVMKKPMCNFSANMEIPRAMFHHKPPQGPPPPPPPSCALQKKPLTSEKDPLGILDPIPSKPVNQNPILINATNFHSNVHSQVPVMNVSMPPAVVPLPSNLPLPTVKPGHMNHGSHVQRVQHSASTSLSPSPVTSPVHMIGTGIGRIEASPQRSRSSSTSSDHGNFMMPPVGPQSTCGGIKCPPRSPRSTIGSPRPSMPSSPSTKPDGLHQYKDIPNPLIAGMSNVLNAPSNAAFPAASAGSGPLKSQPGLLGMPLNQILNQHNAASFPASSLLSAAAKAQLANQNKLAGNNNSSSSNSGAVANSGNTEGHSTLNTMFPPTANMLLPTSEGQSGRAALRDKLMSQQKESMRKRKQPTTTVLSLLRQSHMDSPAVPKPGPDLIRKQSQGSFPINSMSQLLQSMSCQSSHVSSNSSTGCGSSNPALPCSANQLHFTDTNINSSVLQNSLTQNLPLRGEAMHCQNANTNFMHGSSPGPNHHLAGLINQIQASGNCGMLSQPGMALGNSLHPNPPQSRISASSTSMIPNSIVSSCNQTSSDAGGSGPSSSIAIAGTNQPAITKTTSVLQDGVIVTTAAGTPLQSQLPIGSDFPFVGQEHVLHFPQNSPSNNNLPHPLNPSLLSSLPISLPVNQQHLLNQNLLNILQPSAGEGDMSSINNTLNNHQLTHLQSLLNSNQMFPSNQQQQQLLHGYQNLQTFQGQPTIPGSGNSSNPMACLFQNFQVRMQEDAALLNKRMSTQSGLTALPENSNSTLPPFQDTACELQQRTEPTLGQQAKDSLNVTGQGDASVDAIYKAVVDAASKGMQVVITTAVSSTTQISPIPALSAMSAFTASIGDPLNLSSAVSAVIHGRNIGGADHDSRLRNVRGTRLPKNLEHGKNASEGDGFEYFKSAGCNTPKKLWEEEQSPGGEINRWKCEEFLDHSTHIHSSPCHERPNNVSTLPLLTGEQHPILLPQRNCQGDKMLEENFRYNNYKRTMMSFKERLENTVERCAHINGNRPQQSRGFGELLSASKQDLLMEEQSPSSSNSLESSLVKDYIHFNGDFNAKSINGCVPSPSDAKSISSEDDLRNPESPSSNELIHYRPRTFNVGDLVWGQIKGLTSWPGKLVREEEVHNSCQQNTEEGKVEPEKLKTLTEGLEAYSRARKRNRKSGKLNNHLEAAIHEAMSELDKISGNVSDFFFYFLLYFFGEKKNVVFSNTSITMLSDDQLYNFLSKLEIEKITIIRKY
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNMFNDEEFVAHSANVNCLKIGKKTRRNFITGGDDEKVNLWSIGKPTAITSLSGHTSPIESVAFDSTEVLVAAGASSGVIKLWDLEETKGKITNSFITYVKTNIINCNQLYKNLNFCLIPNSNAVVRTLNGHRSYCTAVEFHPFGEFFASGSMDTNLKIWDIRKKGCIHTYKGHRRAVSTIRFSPDGRWVVSGGLDNVIKIWDLTAGKLLHEFKFHEGHIKSMDFHPLEFLLATGSSDKTVKFWDLETFELIGTTRPEATGVRSITFHPDGRTIFCGLDSSLKVYSWEPIICHDSLDMGWSTLGDLCINDGKLVGCSYYQNSVAVWVADTSLIEQSGPSNLAEENTRMPHKFKLQKDLTERVESPRRSTMSSDDDTKDIKNIYVDTAGMTPVSSKVVNLQNPKEIHNLVTPNPTLPPAAAKITSKPLINEQDNTAASLKPSHRRKPSTTKLDIEGLSITVESGLKSGSDPDAAKVSNLQRRVLSDDAAKDSSEEKTKESQKASSPSNESVDSNKELKSVKYVNGVAVVHGRTRSLVERFEKREKLNTDESQLPDPSARVLTNTDTPAPIMNPTPEPEPKTFTMPGKRPDVTKIPIKVPEAETFTIPEKRPDLTKIPIKASASETFTIPEKRPDVTKMPIKTPEAVTFTMPEKIPHVTKMPIKAPEAETYTMPVVTKMPLKEPEAETFTMPDVTKMPLKAAEAETFNMNDVTKMPLKAPEAENFMMPEKIPDVVSSASNEATKSPTRVQKHDSRPNTRSEDTHVQRPRTAPSMLPEKGKVSPMPRSISSRRLMPEKLRTPSPMVVARRSTASSRVMPERTRISSVLVSPRHDTINNRMIPQKPKSSPLMDDNGPQTTGRGLVSKKDNDDVAEDLMTNHDVFLSSLRSRLTKLQVVRHFWEHNDTKGAIDALRKLPDHAVQADVVNVLMERMDSLTLDLFSCLLPVLLELLDSNTERHISVSLQLLLKLVAVFGPVVSSTISAPPAVGVDLHAEKRRGGLVARCAQELNIILQKS
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MELFSLYEFKIEDIKIESILAVNEQEVKDYLLCPICQNILDDPVQFCSSGHVFCRGCIIPWFEKNEESTCPTCREVVPSERGASPYFLSSNMEIKRKLNKIKVYCPYYYTNSKLECIDEVNGCKEIIMYGDLEEHTSQCQFIFVKCELDSFHIYRAKDNHIKECPSVIKKCKFCSENYQRKSKDLHSLLCSKKILSCPLEKYGCLEEFQRCQKITHLQQYENHYKILTNKIDRLSLEIEKASYYKIIKYKKPGFMNKDLKFDAEKYSTLEIFYISKKDIIYQERISVTEFSWKVNKLANIYWDKANKVVFVLTRRSPKENINEKYLEKIHPQNQ
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MGEQNEPVVQDFEKYFQLHSIKNKKTRKNENENKMAGAFDRSAVSIEAQPPFDPEPFEQYFEHWNEILKRFPLLFYGLGSKIELLRAFAEDMLVDQGYVVEVDGFSGQPRLIQNAISQLCDLEQVKKNVDTLNRSLRTLRRYAFIIVHCIDDDCMSDDDTRRDLIEIANSSNIFLIASLDRIPLWSLNFYTSMKFFTINVNTNRLYSQEIGFTMSAKSAVVLDSIERYDIVLKTLTETARVVFGVLAKYQMKTGKGLTASAWQDKAQAELFIRMRDSFNTQKNEFLDHKLIAQKKDTDLYTIPLSQQQLSALMERLFPSTDKQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAQQVEEIEQDLSHIHWSWPEAIAANPARSLATPDLAMDYFAYSPFWDAKSNNNVLRTQRRIENPAYGHAEEKVELNAFMSGFEYVVAHSQPPDLFVIHRREVESSGKRDRVTGAWFILHEKIYQCPTLFDVMSTRLKNATSLISKTLSTLSENRPPANPRTTTLWRSIPSVTSNQPDGTQPSSLDQAEKPDEGKKDDSLNGSSPLDGSDGKASPAGPDWHLFHALQATRASLVSLETLAKTPTQTTDPREELNNIEIAMDNQFGGQNQSLSGKGPNVKGGAAAVKNISVPFVPKHSAGHATSTTGLTPSIWGGSASLGVSTAAVPAREAGGSPLKWPGGDKSAPIAGATLAGQTGR
The following text describes a protein:
Function:
Displays ATP-enhanced chaperone activity. Required for the proper folding of the peptidoglycan endopeptidase RipA and its secretion through the TAT secretion system. In vitro, prevents thermal aggregation of MalZ protein and protects the functional activity of the restriction enzyme NdeI from thermal inactivation; Could be a moonlighting protein that uses a multipronged approach to dampen host-directed immunity for efficient replication, survival and pathogenesis. Can enhance virulence by inhibiting autophagy and apoptosis, and disrupting cellular bioenergetics. Binds and activates host TLR4 on the surface of macrophage cells, leading to the activation of the host NFKB and MAPK signaling cascades and enhanced secretion of proinflammatory cytokines. Inhibits autophagic flux via activation of PI3K-AKT-MTOR-ULK1 signaling cascade and represses apoptosis via inhibiting protooncogene c-FOS and MAPK JNK1/2. Also induces robust disruption of cellular bioenergetics by metabolic reprogramming to rewire the citric acid cycle intermediates for its benefit.
Domain:
Contains an ATPase chaperone domain along with a nucleoside triphosphate hydrolase domain.
Sequence:
MTSAGGFPAGAGGYQTPGGHSASPAHEAPPGGAEGLAAEVHTLERAIFEVKRIIVGQDQLVERMLVGLLSKGHVLLEGVPGVAKTLAVETFARVVGGTFSRIQFTPDLVPTDIIGTRIYRQGREEFDTELGPVVANFLLADEINRAPAKVQSALLEVMQERHVSIGGRTFPMPSPFLVMATQNPIEHEGVYPLPEAQRDRFLFKINVGYPSPEEEREIIYRMGVTPPQAKQILSTGDLLRLQEIAANNFVHHALVDYVVRVVFATRKPEQLGMNDVKSWVAFGASPRASLGIIAAARSLALVRGRDYVIPQDVIEVIPDVLRHRLVLTYDALADEISPEIVINRVLQTVALPQVNAVPQQGHSVPPVMQAAAAASGR
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDAVDSVVDPLREFAKDSVRLVKRCHKPDRKEFTKVAIRTAIGFVVMGFVGFFVKLIFIPINNIIVGSG
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MVQWAMRLPTRHCFEITNSDSQNCDQNDGIPENGAIVCVGDDEFQSDPSSSPDHDSILLPKELEGLHEKYSATLSRASISNIKLQTREHDGKEIAFKILKSSEDFLKEFMLEIEIIIALNHQNIISLFGLCFEDNNLLLVYDFLSRGSLEDNLHSNEKYLAFGWSERYKGALGVAEALFFIYTSSLSGFGLAKWGSTTSSHITCTDVAGTFGMIAHATELLTPGNIQVEILLKEERHNVQLLLYCKQNIEICRLYNLDSVSPNDMKIAIMHHWKHGRKGSRIFWLQQAHDEVRLNRNAQKLFDFVGKRKKHGRSLFSLESGIGVLSDGLALLLPKPKALWGALSYLKPR
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MLLQNIPAIAVVLKDKDVLSIPKEELKGADLIELRVDMFEKTENISDIFETAKRKYNLPLLCTIRLPEEGGKREIKNRVEIYQAVIPFCNFFDIEIFSNEAPFLRQLSIKNNITLIGSYHNFINTPSMEQLEEVFDRGKTMGMDIIKIATMVNEKKDIETLLYFTLRHKLDRIIVLGMGQKGIPSRIINPVFGSMITYASLNEISAPGQIHLKDMVHIFKVMGLRG
The following text describes a protein:
Function:
Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Subcellular Localization:
Mitochondrion.
Sequence:
MGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGFYTNRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFLETVAPAIEKDFKEGTFDANNLEKYGFEPTQEGKLFQLYPKNFPR
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase that may regulate the response to iron deficiency and thus contributes to iron homeostasis.
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus.
Sequence:
MEGKDYPASMISHKNDGAYSVSEFTGEHPIDTVMLWHNAIKRELNEILEKAKTIHISEAYDLSVFSDKLHFIAEICIFHSVAESKVIYPAVYGKNLSFQEHSKEEGVFNQFRCLIESIQKAGTISSSVAELNSNICSHVDQIMETLTRHFHDEEVQVLPLVRKHISITRQRELLHQTLCVMPLKLIESALPWLVNSMTANEARNFVENMQLAASDIALVQLFCGWASKPFNDSFCSSAIGCCSVKRFGNRDEDFGQSSGTCASALSTRDICCAAYQETNAFNSRGSGCIPCPGLNINSPGLSTFSKVKSISFLHLNSIGPSHSVWETYNSFSATGLTEQPIDVVFQVHKAIRRDLEYLDNESQRLSNCDEIFLQQFIGCFCLLWSLYKAHSDADDYIVHPALESRDALHNVSHSYTLDHKQEEQAFQNISDVLFELSHLHASTIGFSSTQCSESSDRVQKFYELAISVHVMFKTLRMMVNQHMSREELELWPLIGKHFSVEEQNKMVGFILGTTGAEVLKSMLPWVTSALTADEQSKMMNNFKQVTKNTMFNEWLTECWNETSLSTSQTGKLETRISPKGSLRRIDHTFKSRKKNNLKNLMTSYWMAAQQSLPQALAEDRFDGDDSVGQSPEFRDPEKRVYGCKHYKRNCKLHAACCGRLFTCRYCHDMSSDHTIDWKATTEMMCMQCLNIQPVGPICSTPSCNGFPMAKSYCSTCKLFDDDRNVYHCPFCNLCRVGKGLGIDYFHCMTCNCCLGIGLVNHKCREKCLETNCPICNEFLFTSTASIRALPCGHFMHSACLEACSQSHYSCRVCSKSSGNTTMASAQSSILVGGDETMEFFNCDQRAQMETSWTNTNPEGRFIGRAWFWVNMLYHSLLWFELHNVKHPRFLQGLKRGLENAVAGQKTKDRFLMCCLALCVLVLFFVLSAVLILLWFKALGRNKYNIFMW
The following text describes a protein:
Function:
Involved in the biosynthesis of alanine. Catalyzes the transamination of pyruvate by glutamate, leading to the formation of L-alanine and 2-oxoglutarate. Is also able to catalyze the reverse reaction.
Subcellular Localization:
Cytoplasm.
Sequence:
MADTRPERRFTRIDRLPPYVFNITAELKMAARRRGEDIIDFSMGNPDGATPPHIVEKLCTVAQRPDTHGYSTSRGIPRLRRAISRWYQDRYDVEIDPESEAIVTIGSKEGLAHLMLATLDHGDTVLVPNPSYPIHIYGAVIAGAQVRSVPLVEGVDFFNELERAIRESYPKPKMMILGFPSNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGARDVAVEFFTLSKSYNMAGWRIGFMVGNKTLVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIAEQYKRRRDVLVKGLHEAGWMVEMPKASMYVWAKIPEPYAAMGSLEFAKKLLNEAKVCVSPGIGFGDYGDTHVRFALIENRDRIRQAIRGIKAMFRADGLLPASSKHIHENAE
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MFMINLFLLIIPILLAMAFLTLAERKILGYMQLRKGPNVVGPHGMIQPFADAMKLFIKEPLRPLTSSSSLYTIAPTLALTIALVTWIPLPLPYPLINMNMGLLFILATSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEFTLAIILLSLLLMNGSFTLSTLITTQEYLWLIIPSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYTNIIMMNALTTTLFLGALYNLHMPETYTTSFAIKTLLLTILFLWVRASYPRFRYDQLMHLLWKNFLPLTLALCMWYVSLPVLASCIPPQA
The following text describes a protein:
Function:
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA). NADPH is also effective but yields only 39% of the activity obtained with NADH. Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene.
Sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI