lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NB-LRR receptor-like protein that modulates growth, cell death and freezing tolerance in a temperature-dependent manner. May be involved in defense responses.
Miscellaneous:
MISCELLANEOUS: The gain-of-function mutants chs3-1 show no visible phenotype when grown at the permissive temperature of 22 degrees Celsius. Mutant plants (chs3-1) germinated and grown at 16 degrees Celsius show developmental defects, including dwarfism, with small and curly leaves, early senescence of cotyledons, constitutively activated defense responses and enhanced tolerance to freezing temperatures.
Sequence:
MEPPAARVTPSIKADCSHSVNIICEETVLHSLVSHLSAALRREGISVFVDACGLQETKFFSIKQNQPLTDGARVLVVVISDEVEFYDPWFPKFLKVIQGWQNNGHVVVPVFYGVDSLTRVYGWANSWLEAEKLTSHQSKILSNNVLTDSELVEEIVRDVYGKLYPAERVGIYARLLEIEKLLYKQHRDIRSIGIWGMPGIGKTTLAKAVFNHMSTDYDASCFIENFDEAFHKEGLHRLLKERIGKILKDEFDIESSYIMRPTLHRDKLYDKRILVVLDDVRDSLAAESFLKRLDWFGSGSLIIITSVDKQVFAFCQINQIYTVQGLNVHEALQLFSQSVFGINEPEQNDRKLSMKVIDYVNGNPLALSIYGRELMGKKSEMETAFFELKHCPPLKIQDVLKNAYSALSDNEKNIVLDIAFFFKGETVNYVMQLLEESHYFPRLAIDVLVDKCVLTISENTVQMNNLIQDTCQEIFNGEIETCTRMWEPSRIRYLLEYDELEGSGETKAMPKSGLVAEHIESIFLDTSNVKFDVKHDAFKNMFNLKFLKIYNSCSKYISGLNFPKGLDSLPYELRLLHWENYPLQSLPQDFDFGHLVKLSMPYSQLHKLGTRVKDLVMLKRLILSHSLQLVECDILIYAQNIELIDLQGCTGLQRFPDTSQLQNLRVVNLSGCTEIKCFSGVPPNIEELHLQGTRIREIPIFNATHPPKVKLDRKKLWNLLENFSDVEHIDLECVTNLATVTSNNHVMGKLVCLNMKYCSNLRGLPDMVSLESLKVLYLSGCSELEKIMGFPRNLKKLYVGGTAIRELPQLPNSLEFLNAHGCKHLKSINLDFEQLPRHFIFSNCYRFSSQVIAEFVEKGLVASLARAKQEELIKAPEVIICIPMDTRQRSSFRLQAGRNAMTDLVPWMQKPISGFSMSVVVSFQDDYHNDVGLRIRCVGTWKTWNNQPDRIVERFFQCWAPTEAPKVVADHIFVLYDTKMHPSDSEENHISMWAHEVKFEFHTVSGENNPLGASCKVTECGVEVITAATGDTSVSGIIRESETITIIEKEDTIIDEEDTPLLSRKPEETNRSRSSSELQKLSSTSSKVRSKGNVFWKWLGCFPLQPKNLRSRSRRTTALEEALEEALKEREKLEDTRELQIALIESKKIKKIKQADERDQIKHADEREQRKHSKDHEEEEIESNEKEERRHSKDYVIEELVLKGKGKRKQLDDDKADEKEQIKHSKDHVEEEVNPPLSKCKDCKSAIEDGISINAYGSVWHPQCFCCLRCREPIAMNEISDLRGMYHKPCYKELRHPNCYVCEKKIPRTAEGLKYHEHPFWMETYCPSHDGDGTPKCCSCERLEHCGTQYVMLADFRWLCRECMDSAIMDSDECQPLHFEIREFFEGLHMKIEEEFPVYLVEKNALNKAEKEEKIDKQGDQCLMVVRGICLSEEQIVTSVSQGVRRMLNKQILDTVTESQRVVRKCEVTAILILYGLPRLLTGYILAHEMMHAYLRLNGYRNLNMVLEEGLCQVLGYMWLECQTYVFDTATIASSSSSSRTPLSTTTSKKVDPSDFEKRLVNFCKHQIETDESPFFGDGFRKVNKMMASNNHSLKDTLKEIISISKTPQYSKL
The following text describes a protein:
Function:
AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients. Required for phosphorylation of ribosomal protein S6 (RPS6A/RPS6B) at 'Ser-232' and 'Ser-233'.
Miscellaneous:
MISCELLANEOUS: Present with 1470 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MIFSLDEELHRVSLDDKKNDIKVDYSSAIYNDINHEQGSSITYEESINHLSVHSNAIPLNGMSPAHRMRRRSSAYSKFPILTPPNTRRFSITGSDAMRTNTNRLSITPQDIISSNIGENELSRNLHDFKPVRVLGQGAYGKVLLVKDVNTSKLYAMKQLRKAEILISQTATDSKREDEDKNDGNNNDNDDGLSKRLERTFAERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLKEHGTLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSANDSAVDEEDPENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTGSNHKVIINKIQQNKQGPKIPFYLSEGMKDILNALLKKETAKRWNVDKYWAKTGANNKPTKSKKKKSGAARTSLFTEHFIFRKIDWKLLESGQLQKTTLGPIVPVITDLELAENFDTEFTSMSYEETYTDSKPININSVSKSPDMFKGFSYKASGSYLEKYF
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MRIESQKLNRKEVHSEFSRHKQTSKESMAHERKLKEAQELQAKTAAEATNTDYDRVKNLTYTIDDVERWEEKLSQKEARKDHGFSDYAQIAAKKYSKMIADIKPDLTKYRQQANIASMTHGSSDGTQEIVSEDAFYRSAHSLSYANHSAAPDELAVDRLVKDIEKQRAQRGQFSRRRAFDDEDEVTYINERNMRFNKKISRAYDKYTADIKANFERGTAL
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MFFTGTLQEGIAAAIQQTRSLVCFVTDDNTESQQWETEFLKDEAISPLIESRAVVLKLVAGSTEEGYLAQLFPLPKKPTVVVLRGGQLKEYIAAGVTKEEFVRRLGAAVGEQQAVSTAANTGSASVEEPETVQNQEQASPTAAPSEPAPQLSAEETTVPTTSSTDDTISQPPPTDNTTSTETTETTSSSSPTTTTPTTNTTQQARIQAILAERAARLAAQKKQQEEAARAAARARAAAEDPNSPARQAADALRKKQQEAREERQRILKAIEDDKAARKARQSEKQREKEAFAATKESGGKDEDEKGEGLLPFAPASPMLPRGNQPVKSTGHCALQVRLTDGSTIRSRFSAEKDTVREVREWVEATVAESSTVKKGRYTFKVLLTPQPSRRIEQAEEGKTLGELGLAPSSTLILVPAAGGSGNGGRVRFAAAQADEGGNIFQRLIGFLAAFFSTVVAFFSTLFSVSGPPNAGPTPEEVASEVRGEQQQQQATRAERASGRSLGGGGAGAAVNRGAGSRIKGFGDERRDEERKRNDQQFYNGNSTNFEPRHDDHDN
The following text describes a protein:
Function:
Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Sequence:
MADKLYQIKLDIKKGKNIVGSDGSVCSPYLRVTWGGKKQQKTKVITKSAEPEWNFSCLLEIKKEKNPQKPGLEFELIEHKQFSEKEISSTTYQLPESLILGEACNYSVPMSIATSKGDQKCEILIAITAINFGKDKQDEEKKRHDEIQKKFAQLVEQLATDSKAREGMMKLPYEARAQLVEQHRDKLANEKHPDEYVVLLIKEITRKNIQLAGGLQKSHSASNASLGSLSPVTPRVDDGLSVAELKNISVALRSRGLDWIHQFHKLGATTRLVELLSLYVNKKSHTEESLQKQLECLNCIKNLMNNNVGIGYIFGIKDSFKTIVLCLGSEYEKVNELAIGLLNTICFLPKINGHKLLIELLNYFKEEKKESRRFISIVKSLKSKAGVIETKETLKTKSIYLSFINIIVNTPAEIDLRLALRQEFYWLGIKEILVKLSNYTYDESPELDTQITVFEEEESKDNKEMSERFQEFKGLNLDNVDDVLKTLMDRIRPKGLVDCMREISKDLLLLPIDDDVGIRNWVLASRIIKQISLRDKNIGIDEDILPLENLLLMCEQEAKEVPLKSQIESLKKDAQDLAKKITTQDIELKEKVEIIKKNEELTTKQLEEQINIAKKKDEEINQLKALVEQLKLTQGTAKPDSAAASTSVAPPPPPPPMTGGGAPPPPPPPPPMTGGGGPPPPPPPPPMTGGGPPPPPPPPPMTGGGPPPPPPPPGGGPPPPPPPPGAKAGGPPPPPPPFGKGPPPPPGGFGMKKAAAPPRKEVPVPALKMKGLQWVSLNDKKIQGTIFSKFNLDTSKDINLDYKDIEGVFAAKVIEKKESTAPKKTGPVSIIDPKTSQNLSIFLSQFKGKSYDDICGAISKGDETVFQPNHIDALIGFLPSEDDINNINEFLREEKDITKLGPPEQFSMKIHSVPQVKARLQAMKFKYAYESKKSDLKVDIDNFKQGTQEIKGSEKIPKLLEVILILGNFINGGTARGNAYGFKLNTITKLADTKSTDNKLSLVNYLTRVVIKDFPHLNSFAQDLGHVEAAGRVSLSQVQAEVATLRKEFVQVQKSIETLNSGTGEEAVDPFKVKYEEFCTQTAEDIDLITSSSQQIETDYKDLLAMFGEDSKSEPSEFFGMFTKFMDQYDKATKENEQLSIQAEKIAKREAAKKLKEEEDAKKKQLAEERKQKGETVEVKESVVDDLLDTIASGDAFKNRRRRARKTDQDSTIEPIDL
The following text describes a protein:
Function:
Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSNEQVHVDIANSVMDEKHFRVNHLGENYNIYEFLNNHPGGINYVKPYEEKEVTQRMQQTQHSKAAYYLLREYKDGGRDSSNKGDQEDLEALVDWDKPMLAQVANLGAKYNEWVISPVDRKLRLFGNPILENLTITPWYVVPLVWVPVILYFIIHGTRKYVQLTEDPSPFLPTVLSVVLGVVLWTLIEYSLHRWVFHMEPSGKSKVMIYVHFAIHGLHHKVPFDPRRLVFPPFPAAVIAYVLYEICTFFVPDSIIFLVIAGGLAGYVIYDMIHFYLHYGSPKEDSYFYYLKRYHNQHHFAHHDSGFGISSVFWDKVFGSAIKLRQLAMAIKW
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MLEITGASEVGSKEGKLEEVELDLDLSIGGSYGKSEKARESAKGLALESALGSDGAFPGGADNGGARKDRPVSPELTGSDLETGGSESDPERKRAMQAMRRFEAKRKREEKRRRKGGADGAGRSDLAGEPARKKAKEEGADGKHGGEGSAAAATAHPVCPPYLVVPVQFPYGPFVNGYGIPYWVPGPGKSDGVLGLGQNVSEQSSSGKKTSSSNGSQLCSSSGVSDCQGSSPRQGGTSYDAKNRSTASSRKRRLPERNSSHHTSESAELTDEAKNLSDEKADSTSPTRSTDLTKPNEDAGFITQGPPQNPDRECANPRSASPNGGAGKPPRPSPPLIRMPRVSTTGNGPNGKTVNGFLHKYSKAEVSIVCTCHGFTFSPAEFVEHAGGTNVLHPLRHITMVP
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein. Peroxisome membrane.
Sequence:
MSEGGSNEGAESPPPSSSAGVDSTGTSETTAPVPPLPPREHLIVTAVKFLNNPNVVRSAITKKQAFLRSKGLSEDEIQIACERAGVFTTSPTQQTVISMGVESSGGGNYAKPGYQIQPRQNFLTRMKDMLSSVALLSGLMYGVYLFYKKFIEPLLFRSKKKKTVTEQLTELNQTMTVKIDTLSAELSKIKAELNQVNQTNATVKELANFKGDLDSIKGLLLNRKQFAAPNLPVVPPSIPAWQLRSQQHQPASSEGEHDKHDDNDTGSGSGSSENDVVLKNSDSSLEIIS
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLFNYLRKPNPTNLLTSPDSFRYFEYGMFCMGWHTPATHKIIYYITSCLIFAWCAVYLPIGIIISFKTDINTFTPNELLTVMQLFFNSVGMPFKVLFFNLYISGFYKAKKLLSEMDKRCTTLKERVEVHQGVVRCNKAYLIYQFIYTAYTISTFLSAALSGKLPWRIYNPFVDFRESRSSFWKAALNETALMLFAVTQTLMSDIYPLLYGLILRVHLKLLRLRVESLCTDSGKSDAENEQDLIKCIKDHNLIIDYAAAIRPAVTRTIFVQFLLIGICLGLSMINLLFFADIWTGLATVAYINGLMVQTFPFCFVCDLLKKDCELLVSAIFHSNWINSSRSYKSSLRYFLKNAQKSIAFTAGSIFPISTGSNIKVAKLAFSVVTFVNQLNIADRLTKN
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAMASTDTELEEQLLEAGNKLLLDPLSSVEDLLPLLDQVESCLSRVEQSPNDSMRNALSPSLKALITDKLLRHSDDDVKIAVASCVSEITRITAPEAPYDDDQMKVVFLLIVSSFENLHDKLSQSYTDDIFLQVVFQLIVSSFENLHDKLSQSYAKRTSILETVAKVRSCVVMLDLECDALILEMFQHFFKAIREHHPENVFSSMETIMTLVLEESEDISLDLLSPLLASIKKDNEEVFPIVQKLGERVIECCATKLKPYLVQAVKSLAISVDDYSAVLASICQDTSDDLEKNDTCVTSELVEDKSDSAKQSPEESTHVVEKDSREVAPSQPENTGVSISPKLVMSNGVACVGEDNALADSKSIKKQEDADFSNHSEGLNISGEEVHNNLDTEKVDNSKQKPKQATKRRRKKSSSSTKSAKPSKGHVAANERETEKMLDHESNNKKVPSPPHEDHSVEAAGPPENDNEIDAKISSPKACNGESEVVASPPRESLYDENLSRKHGRTKKKDGPIKEGAAEDASKVSGGASDSDAKPVRQSVKKALGLKSDVKKASVVDSVKKGSGAVNDADAKKHSAKKLDENKKGSGGSSSRQMEDKKKGRRGKANSETDVAKSSAMELDKEMVSSPRSGTKSTKNENSEDTPKTNVKRKRSSGKENESSTKEYGQNLVGLQVKVWWPDDHEFYKGVIVSFDSAKKKHKVLYDDGDEETLNLVKEKWKVIEADSDADKEERSDHTDLDASTDMPPKKKGKRSAGESTKQGKMDASSRSGGAATSSRSKGASTKSSQKSEDGNKSIDSKTISKPEDEVGRKSKASAPKSGSNKSIVTDKKMSNKSKNIDTSKTSESKDDDTSTPKPSAKSKQETPKSGKSKQETLKTLISKRKPFKSGGKTDVNGAGKVKFGLLKRKYSENENSDV
The following text describes a protein:
Function:
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
Subcellular Localization:
Midbody.
Sequence:
MGESDRFCYVYSCDLDISVRLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYADLPRSAQVALTIWDVYGPGKAIPVGGATVSLFGKYGMFRQGMHDLKVWPNIEADGSELTKTPGRTNSSASEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFPCVKCDEKEYGIVYYEKDGDESTPISTSSEIVRVPDPQMSMENLVEIKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTSEEQDLVWKFRSYLTSQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHFTNPTVRRYAVARLQQADDEDLLMYLLQLVQALKYENFEDIKSGLEPTKKDSQGPMLESMTTSGINPETDSSQILSNPLPAVSSPAPPSKTKDGLDAETLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQLRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLATQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSEFEPIPLPLEPQVKIRGIIPEKATLFKSALMPAKLYFKTEDGGKYPVIFKNGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLATEGSIQNFFRKYSPSEKGPYGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQAFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQTLIDDSVNALFAAVVEQIHKFAQYWRR
The following text describes a protein:
Function:
Self-assembles to form a helical, filamentous nucleocapsid mesuring 900 nm in length and 24 nm in width (Probable). Together with capsid protein 1, wraps arounds the DNA and maintains it in an A-form (Probable). Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
Subcellular Localization:
Virion.
Domain:
The N-terminus projects into a DNA groove.
Sequence:
MVNKKYRQDSKDRYQYKQYIYRSIGGIVPPEMAETVTANQTAQWEAGFTPYHKLRLAIKEICKTDGIPNIKWGMYIAFGEKLLKSYLKMKAGSASSDMIAEYINNAISAFSSRTGISQETAQKIADFITSNY
The following text describes a protein:
Function:
Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MFGRLYFMLLLSVGLVDCLSVVKDCITNNGEDYRGTQQKTSSGSTCLSWRSLNLKFKDSQTGVGDHNFCRNPDGSNKPWCYVSGSSGETKKEACDIRICQDQNATEAPAPEESVPTQGLTQRMVETFEPANSFPSQVEGAAVQPVKGVRQQVRSGPKKKKDLGTLGYVLAVFMMAIIILLGGGITMGYFYKRGRDLKKQHEQRVYEREMHRITLPLSAFANPTCELVDENTIVITAEPNNQTPTQEPVEGADPLMGSAGTPGA
The following text describes a protein:
Function:
Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.
Miscellaneous:
MISCELLANEOUS: Present with 1100 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud neck. Bud tip. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Concentrated at the incipient bud site of unbudded cells, at the bud tip and mother-bud neck of budded cells, and at cortical sites on large-budded cells that may delimit future bud sites in the two progeny cells.
Sequence:
MTEGKRLQQMELPQMKSIWIDEDQEMEKLYGFQVRQRFMNGPSTDSDEDADEDLGIVLVDSKKLALPNKNNIKLPPLPNYMTINPNINSNHKSLTNKKKNFLGMFKKKDLLSRRHGSAKTAKQSSISTPFDFHHISHANGKREDNPLESHEEKHDVESLVKFTSLAPQPRPDSNVSSKYSNVVMNDSSRIVSSSTIATTMDSHHDGNETNNTPNGNKQLDSPTDLEMTLEDLRNYTFPSVLGDSVSEKTNPSSPSVSSFSGKFKPRELSALHTPELGNCFNVDQSLNSPGNRISVDDVLKFYYQCSETSTPRNT
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MSWHFLERWVEKANQHSTLVGKFWITFLIVCRMVIVASVGDRVYNDEQSEFKCNTLQPGCTNVCFNRFSPISHLRFWSFQILFVATPSVMFVVYSAHKSKLKKTSSKKAFPRSTMIRLGKQLSDSERTKSWEEETTHRHQKRYSRNSRRGISSSNTSGVAFAQHFRWYLANVFVRLCIEVGFLVLQVLLFGFHVPELYKCERRPCPNTVDCFISRPMEKTIFLWFMFLYSCICVALNLVEFVYLVYAYIKKQAQKRVSSSKSKKEVSLHPNKDSGLSR
The following text describes a protein:
Function:
Required for required for normal vacuolar morphology and for vacuolar protein transport. Also required for endosome-to-Golgi protein transport.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein.
Sequence:
MAKLSSLLNPIISKILEIYVYSWYSGISKDALFPSQCEQVGGSIVHELEKRLSRQDAMDLLFYEIPFLLIKHIENTEEAKLRFALPQGQILEIDTIYHSLHPHIALEKEENELVYCRLLVEDILKYLLPATNSKSEIECVILREALAVQIHKSIQVASSPETMYKFIIYLSKAILQPSRRPWKESITTAVRWVWHAFRILLITRGVPYFSTAWFQFYLKLFSQKDNVSSSDLTRWFFFYTLLYPWIALVSAFVAETMTLCCIVTIFYDKNVNRQWKQYILTSVSNMDKGNPSGGSQSTNVTTFRRFSQSSYPRRSNYRRRISTSSKSLYELSPSKFKSIPITSNPPPMLNLSKGSTSVEPTFCETNASVALSTVTSTPVFSTDSSPLSSRTRENLLSLIPSAVSSPTKANTNKSHQRSFSIPKATKDSQTPSENSAATLKQAAIDAYSQIPVIPFFLPSDKLIMLVESEYRNKHIFYSLLNSFTMVMFPELRHTK
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain; in CFT073 however it does fulfill this function; Low level expression in a deletion mutant increases resistance to acidified sodium nitrate which causes nitrosative stress.
Sequence:
MILFVGFLLMEIVMPQISRTALVPYSAEQMYQLVNDVQSYPQFLPGCTGSRILESTPGQMTAAVDVSKAGISKTFTTRNQLTSNQSILMNLVDGPFKKLIGGWKFTPLSQEACRIEFHLDFEFTNKLIELAFGRVFKELAANMVQAFTVRAKEVYSAR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS29 binds GTP and is probably an active GTPase. GTP hydrolysis may be linked to subunit association. mS29 also has an extraribosomal function, being required for maintenance of mitochondrial DNA.
Miscellaneous:
MISCELLANEOUS: Present with 1300 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLRMSTSRFIGQRLFTTARSLQAAKPAPKGKTQGFSKKSSSVSSYSSAKRVTPGSLYKNWTNTTHTAQLQQTAVPLALPIFNFDDISKTLNKVVSYSNKQYKSLHHLGSFKKSQFNELFQKPVCLVREDATNSFLKKLVSHPVKKFIITGEPGVGKTVLLSQAHAYAVDSKQIIINISYPELFLNGRNDFSYDDDLKLFIQPMYLKKLIRKILKANDPALLKSIELSKDYKFSNANPKNASVKPFVTLNKTKNTVLDLLSVMTHPHNRGKLMKAIIDELSVQSKVPIMFTVDNFSKVLTTAYSAYRNTENKQIYSLDLQMGKLMMDIISGETKFANGESSTILAISGVDRTNKTLPVALGKIPVDPYVTRYHYEPKFVELLQKGNVTEFEVPKLNKQEVNELIDYYKQSNVLLDKDITGKKWENLIDEKYFLSGNGNPRELLKSLVLSHR
The following text describes a protein:
Function:
High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MHVLNILWVVFGIGLMLVLNLKFKINSMVALLVAALSVGMLAGMDLMSLLHTMKAGFGNTLGELAIIVVFGAVIGKLMVDSGAAHQIAHTLLARLGLRYVQLSVIIIGLIFGLAMFYEVAFIMLAPLVIVIAAEAKIPFLKLAIPAVAAATTAHSLFPPQPGPVALVNAYGADMGMVYIYGVLVTIPSVICAGLILPKFLGNLERPTPSFLKADQPVDMNNLPSFGVSILVPLIPAIIMISTTIANIWLVKDTPAWEVVNFIGSSPIAMFIAMVVAFVLFGTARGHDMQWVMNAFESAVKSIAMVILIIGAGGVLKQTIIDTGIGDTIGMLMSHGNISPYIMAWLITVLIRLATGQGVVSAMTAAGIISAAILDPATGQLVGVNPALLVLATAAGSNTLTHINDASFWLFKGYFDLSVKDTLKTWGLLELVNSVVGLIIVLIISMVA
The following text describes a protein:
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein.
Sequence:
MGKDRLPELLQRSLSTNSSNSSSNGSLLLNVYSGTTEFIIGNTGGNNNSYSVVSQNSHSCSNNNSSTEPKDRSSSKMTQYGSNVDDILNPYTEIRQQLAQIAANLETMNRMAQTVNLRTFNENEMDELHNKNLRLGNQLMTRFNDFKANLPAENDYSLEARMKRTLFYGLHQTFINLWHKNELFLQNYETKVKKNLRLHTKIINSEASEQEIELLIENKTTKLFVDNFLQETEKERQTLREMMDRFNELRRLEKSIEEVHALFMRIQTLVMEQSEVIQRVEFHAQQATLHVDKGADELDQAEQHQKKARKKKIMLIVILAAVLLVLLLVGIYL
The following text describes a protein:
Function:
Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGIKTALPAAELGLYSLVLSGALAYAGRGLLEASQDGAHRKAFRESVRPGWEYLGRKMDVADFEWVMWFTNFRNVIVFALSGHVLFAKLCTMVAPQLRSWMYAVYGVLAVVGTMGPWYLLLLLGHCMVLYVASLLGQRWLCLALGLASLASFKVDPGISWQSGFVTGTFDLQDVLFHGGSSFTVLRCTSFALESCAHPDRRYSLADLLKYNFYLPFFFFGPIMTFDRFHAQVSQEPVRPEGELWHIQAQAGLSAAAIVAVDVFFHFFYILTIPSDLKFASRLPDSALAGLAYSNLVYDWVKAAVLFGVVNTVARLDHLDPPQPPKCITALYVFGETHFDRGINDWLCKYVYDHIGGDHSTVIPELAASVATFVVTTLWLGPCDIVYLWSVLNCFGLNFELWVQKLAERGPLAQIEARLSEQMSRRVRALCGAVNFWAIIMYNLVSLNSLEFTELVARRLILTGFPQTTLAVLFVTYCGVQLVKERERSLALEEEQRQDREKLE
The following text describes a protein:
Function:
An NAD(+) hydrolase (NADase). Upon activation catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggers a defense system that promotes cell death. In addition to ADPR, also generates a cyclization variant of cyclic ADPR termed v-cADPR (2'cADPR). Also hydrolyzes NADP(+), but not other NAD(+)-related molecules. v-cADPR activates ThsA, an NAD(+) hydrolase in B.cereus (AC J8G6Z1). Probably makes 2'cADPR; the cADPR made by this protein is bound by cmTad1 (AC P0DW61) and activates ThsA from B.cereus. Boiling cmTad1 bound to the cyclic nucleotide releases 2'cADPR, strongly suggesting it is the product of this protein (Probable).
Domain:
The TIR domain catalyzes the NAD(+) cleavage (NADase) activity. In contrast to classical TIR-NB-LRR receptor-like proteins, only contains a TIR domain (Probable).
Sequence:
MASSGLSSRRSIMASRLTASAEAVNEPRRGAVVSRRVEYDEESLAGAGGESRYEVFINHRGVDTKRTVARLLYDRLAQAGLRGFLDNMSMRPGDRLEERIGSAIRECTVAVAIFSPSYCDSEYCLRELAMLVESRKAIIPIFYDIKPSDLLLPQAVADSEVYLPRDLERFKFALREAKHTVGITYDSATGDMAELVSAAADAVMYNMEKMETVQRRETMILSRL
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Sequence:
MVWSSVRLAGSVLVHLMPGVSPMEINLKLSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGKLPNRKYAVISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKHISGDIFFPELPRDLTLVFEQRFSSNIDYTYQIWQKG
The following text describes a protein:
Function:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCEQLARLHGCNILIIGDNDCLVNKYGHSVTIACGYDPQGMSVRILKEGGGGGGGGGGGQQLEEYPVNAKTTHLNHGHTSHVVVAGGEMLYLKFASKADCQLFRSLLQKMSGKVNSVFNLRTEDSSASQYFQFYGYLSQQQNMMQDFVRTSTYQRAIYSNSQDFHNKIVLDVGAGSGILSFFAVQAGAAKVYAVEASNMAQYAQQLVHSNNLNGKITVIAGKIEEIELPEMVDVIISEPMGYMLYNERMLETYLHGKKWLKPEGKMFPSRGDLHVAPFTDEALYMEQYNKANFWMQSEFHGVNLVSLRDAAMKEYFRQPIVDTFDIRICMAKSIRHTTNFLTADEKDLHRIQIDVEFHILETGTCHGLAFWFDVEFAGSCSQIWLSTAPTESLTHWYQVRCLLQTPIFVKQGQVLSGKVVLAANQRQSYDVEIDLKLEGTMITSCNTLDLKNPYFRYTGAPVPAPPGSNTTSPSEAYWGQLDAQGARNAVNLVNGITVNGLGEVDMSIINSNMMPMGNQPNIHPGLISSTGRQQSAQQQVTPSQQLTMNPTIACAATSTQNVAQQQLIGGAISPSLFTTPTQQIINSHHAQPIHGGQFY
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSPTRAQRLEGLERIAYCSDVKLFFLVSGSRMFLLLLMLFLRVALPHIYGTELLWDSGTLLYDDMNSTWSLLNFPRSWDGVHFFHVAKHGYSHENVCAFFPLVPFIVRTVSWLNDVLLPEFLTAVPVTFQVALLNVAMGGAAAVCLRRITILTLLSGSHGVDYTNKKDKAMSMTSGTWLDSLPLPPPYYRHEVTVKEHLNARLWKEVGATVLMWMLSPTAVFSVVLYTESVFSFATFLGVYMLIVSPQGKWRTAAAEAGAVLCFAVAGCARSNATTYIGFVLYPVFLQVFFFDTYRKRYAKRYGVTSPIRRWPSLARCVIVLIEVVIIITPYLGLNYLCYSRFVPLWDDMSRAAIGGRFWAFYGWMQKRYWNVGFLQSYRWGNAPNVLISAPIMFFTVRGFVLFIVQPALARSMETESNISKEYQEPRSDCREDRCGNKKQRLFSIYKLMENLVQSSNIICLLVILAFGATMAHVNVVNRLVMSSPALYWLWGRQFVCDPWGGNTVVMVRIFLLWNCIGALFVPNGLPWT