lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTIAVKESKILYGNFDKAKSGIMKGSGGIVEQGPGLQQRIITPAKEMPPEIPHVEFNQLPLSVLIRNLTVYAAKELSQYMKTNVRSTQDASTRKMEFLRLIIFLRNQFLRLYVLVKWCKTIRQNNFHTMIDLLNWFRGTNIIVNNCLLALKDMSTSMAGAKLPNPDLITALEVLMLGRPDLPTHGFLLTGDENGQQANKIPAKLILKRFRDLNTCLSVKISLMDLPAEMHTYSIKDGRITFTVFPEFEISLSTIDRESPLFFVDVKFLFNENKFPLNTTKIALLVNDILYKSPTPLLSLYQFLHRYVLTLQLYMIHVELQDIETNGKYSGGNLAHHYDPKKNIISLRYWLQSKMNSKCKALIGVEKTSQSIILQWHLPDTKEEGKTTKYNNLLGNIEAILDEITFNHARIIMSELLDTGLFEGDDNKNDTSDTLFFHVPVICVATAPVQLKINTISGIFYFKNPSALLLSYAKQLNQTSDLDDVVNILERLRMDKIVHILRNMFEKTGWICEDVVKLNKPILYDKHKDKKRILTRDLFIRIKDWPANWFFILNLVASGATCIVEKLIGKVQSVKGTWEVKYLDQGNLQVSKLESITYQNVMHMQKTIIQKILNHMIIDSLNELKISKVICQGEASQKLPAYVQTNTAGASNVSIIAIGLESFLQGSKALSDTLESTIFLKMDYEQNEVKLFGKFKKDTQMIRYQCDDLLINFIDKRGLAFHMTEDFTSLNHVVQYLTKFRQKLMQLVVLTDVTEKLHNNFRSEHFQIVKLRPNEISFRYLKNSKDDQDCTIQIVTNETKIEKLQVQLSPLNPQNIIQKYLECDKYDPHFIFNYLHFTSKLFSAVKSIESITNTNTMTITLHLHTLAAYQLSYHDRLTGGQIALCIDLRNSPSRAGSMYHLYFAQEDYSASKNPMYPAILQVINNVFMLNNNTKRKVPSVIRLGTGVACPLGDIEPLLEEIHSILIRS
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC3.
Sequence:
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAIDAARDEFEA
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSPPPKHITILGGGLSGLSTAYHLSRVLPASTKISLVEGTSRVGGWIDSQKHELGFKDQRGQMREGVVGIETGPRSIRPRGSRGAASMLKMLEDLGLENDIMPIPFSHPSAQNRFLLDYSTSKLTALPSSLTSFLGRQPPLLKGLLSAGLFEPLKPKAPRKHLTADKDESVDAFFRRRFGDNVADNLASAMVHGIYAASSSQLSLRSAFPSLWEAERKYGSVVIGMLLGTKTAAEKAEEKREWEELGEVGKEREKWSLYGIKGGLGTMTDKLLDRISSRGVEIILGEPVRKIELSSNQEIAIHTHSHSLSTSHVISALPPRVLARTLSSPLPHLTHNPSTCVGVVNVVYPLPPTSIHSAGFGYLVPRPPTNLNPNPSPNPSGVLGVIFDSTALPPNPPELGGQVTKLTLMMGGPYWANYSPRISPPSDPEELLPLAIQHLNTIFPHLRNVKPILAVCNIHHNCIPTYLPGHGARLREMHEAIESGEWNGKLSLVGSGYGGVGVNDCVLPGVDVARRLAKGKEVTGLEAWKDWE
The following text describes a protein:
Function:
Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation. Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP.
Sequence:
MGCLGGNSKTTEDQGVDEKERREANKKIEKQLQKERLAYKATHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGEGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL
The following text describes a protein:
Function:
Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process.
Sequence:
MPGVEKSSQNESRLLLVSNRLPITIKRSEDGKYDFSMSSGGLVSGLSGLSKTTTFQWYGWPGLEVPEEEIPTLKNRLKEEYNAIPVFIDDELADRHYNGFSNSILWPLFHYHPGEITFDESAWEAYKEANRLFAQAVASQVQDGDLIWVHDYHLMLLPEMLREEIGNTKKNIKIGFFLHTPFPSSEIYRILPVRNELLLGLLHCDLIGFHTYDYTRHFLSACSRLLGLPTTPNGIEFQGKIIACGAFPIGIDPEKFKEGLKKEKVQKRIATLEQKFQGVKLMVGVDRLDYIKGVPQKLHALEVFLSDHPEWVGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGKFGTVEFMPIHFLHKSVNFDELIALYAVSDACVVSSTRDGMNLVSYEYIATQEKRHGSLVLSEFAGAAQSLNGSIIVNPWNTEELAAAYHEAVTMSDEQRALNFSKLDKYVNKYTSAFWGQSFVTELTRISEQAAGKLPTKETPVNGETSKLETSSQ
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting (By similarity). Acts at the crossroads between the secretory and endocytic pathways. Is involved in the endosome to vacuole protein transport and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport (By similarity). Also involved in the efficient sorting of seed storage protein globulin 12S.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Sequence:
MMGSENADGFEETNLNAQRDDMENLDLGVDGGDHPLKISDVNGDTSNSGYRSAMSTLSNVRDPLSPPPTVMIPADSDPLLAPSSYEDFRSSFSSKPISSDNSYIEPPSYADVIFSPFDENSDSEINGTEDNSLHSQFSDSLSRSPSSSSSDYIKITVSNPQKEQEISNSIVGGNTYITYQITTRTNLPDFGGPSEFSVRRRFRDVVTLADRLAETYRGFCIPPRPDKSVVESQVMQKQEFVEQRRVALEKYLRRLSAHPVIRNSDELKVFLQVQGKLPLPMSTDVASRMLDGAVKLPKQLFGEGGASAVPVTEVGQPARGGRDLLRLFKELRQSVSNDWGGSKPPVVEEDKEFLEKKEKMHDLEQQIINASQQAESLVKAQQDMGETMGELGLAFIKLTKFENEEAVCNPQRTRANDMKNLATAAVKASRFYRELNSQTVKHLDTLHEYLGMMMAVQGAFADRSSALLTVQTLLSELPSLQTRVEKLEAASSKVFGGDKSRIRKIEELKETIKVTEDAKNVAIKGYERIKENNRSEVERLDRERRADFMNMMKGFVVNQVGYAEKMGNVWAKVAEETSQYDREKQSS
The following text describes a protein:
Function:
Binds to SIN3.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDGPNFAHQGGRSQRTTELYSCARCRKLKKKCGKQIPTCANCDKNGAHCSYPGRAPRRTKKELADAMLRGEYVPVKRNKKVGKSPLSTKSMPNSSSPLSANGAITPGFSPYENDDAHKMKQLKPSDPINLVMGASPNSSEGVSSLISVLTSLNDNSNPSSHLSSNENSMIPSRSLPASVQQSSTTSSFGGYNTPSPLISSHVPANAQAVPLQNNNRNTSNGDNGSNVNHDNNNGSTNTPQLSLTPYANNSAPNGKFDSVPVDASSIEFETMSCCFKGGRTTSWVREDGSFKSIDRSLLDRFIAAYFKHNHRLFPMIDKIAFLNDAATITDFERLYDNKNYPDSFVFKVYMIMAIGCTTLQRAGMVSQDEECLSEHLAFLAMKKFRSVIILQDIETVRCLLLLGIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAKKLKSMSALEAEARYRVFWSAYCFERLVCTSLGRISGIDDEDITVPLPRALYVDERDDLEMTKLMISLRKMGGRIYKQVHSVSAGRQKLTIEQKQEIISGLRKELDEIYSRESERRKLKKSQMDQVERENNSTTNVISFHSSEIWLAMRYSQLQILLYRPSALMPKPPIDSLSTLGEFCLQAWKHTYTLYKKRLLPLNWITLFRTLTICNTILYCLCQWSIDLIESKIEIQQCVEILRHFGERWIFAMRCADVFQNISNTILDISLSHGKVPNMDQLTRELFGASDSYQDILDENNVDVSWVDKLV
The following text describes a protein:
Function:
Catalyzes the peroxidative oxidation of azurin and cytochrome c551. Likely to provide protection against toxic peroxides.
Subcellular Localization:
Periplasm.
Domain:
Organized into two domains, each containing a covalent c-heme in a structure reminiscent of class 1 cytochromes c. The domains are related by a quasi-twofold axis. The domain interface contains a calcium-binding site with an unusual set of ligands.
Sequence:
MQSSQLLPLGSLLLSFATPLAQADALHDQASALFKPIPEQVTELRGQPISEQQRELGKKLFFDPRLSRSHVLSCNTCHNVGTGGADNVPTSVGHGWQKGPRNSPTVFNAVFNAAQFWDGRAKDLGEQAKGPIQNSVEMHSTPQLVEQTLGSIPEYVDAFRKAFPKAGKPVSFDNMALAIEAYEATLVTPDSPFDLYLKGDDKALDAQQKKGLKAFMDSGCSACHNGINLGGQAYFPFGLVKKPDASVLPSGDKGRFAVTKTQSDEYVFRAAPLRNVALTAPYFHSGQVWELKDAVAIMGNAQLGKQLAPDDVENIVAFLHSLSGKQPRVEYPLLPASTETTPRPAE
The following text describes a protein:
Function:
Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
Subcellular Localization:
Cell inner membrane. Cell membrane; Multi-pass membrane protein.
Sequence:
MARATQGSNNVWVIWLSLLVGLVLAVAPMPTFTEIGRPLWLAMLLTYWVLLLPERVGMVTAWLLGLAQDVLYGNLLGQNALILGLITFLVLSLHQRLRMFPAWQQCLVLVVVYGLAQLLQLWLNALTGNRPPTLTFLLPALVSALLWPWVYALLQFVRLRLNVR
The following text describes a protein:
Function:
Multifunctional protein that is involved in the regulation of many processes.
Subcellular Localization:
Nucleus.
Sequence:
MEMKKRINLELRNRAPEEVTELVLDNCHSVNGEIEGLSDTFKELEFLSLANVELTSLARLPSLSKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALDEEDDDDYVEEGGEEEEEEGELPLVRPALTSWGWVGGYLFYRGVRFLPSSRPGPSDSCAFSEVRDPPWKSGAERVPLRPLFSFPSYFKRFLRARRRSKRWGRDETIGSGAVPRAAHGLEPRLSDEARRSEASRPRPHGRRVAEPGGEPRSF
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MEPHPALLHTPGSNACWETESNPSGQHRKGNISPEPKTRPEEKQCNEAKEHEKGTSRESVKTLKHTALASNADLHPASKIPTMHTTTTKQITNANKTASKQPAKSSSSGVEVLSSTSGVKLKSPNVHEKKLQAKLFPKNIQKAPSTSHIMGYTESPQKMLQKTASASQITSTDSPKSLNRLSLSHIPKASSSPKIKATSPTSLKVDKAERIKKLVSKETPSPKDKPIDAESKPGAKTALRESPLGPPEIKSGDSSSVLLHRELNPEQPKAPEDKTDAYVTTQERKTGKSLWEQKEADSTIKNDKMVNNTAYKTSTSKIQKDSETMTHLSAIATKDAAIQTEVTNIDAEIQAVVKLCSKSTEMSPVRNPQTIRLDSDNNPEANLRNDLKRDSNSDSDWLSNGGLMDSTPIGAKPRFLGPPPYKSPNTQKPHQHVCQIEIELRSESPQTFGLNPLDVTISDAEKTSMKCLGKTGDVDGQKGESAAPQQIVWDEQGMTWEVYGASLDMESLGFAIQSHLQCKIREHERRIGTLRKSICLSEQSPVKGRTGKRKRNVFRSLFTGSHCCSKQHPEEGMAK
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTTQTDLQTKLGRLTLPNPILVASGTFGYAREMEGIVDLPRLGGILPKTITAEPRIGNAPWRTVETSAGLLNAIGLDNDGVDAFLEHHLPYLAGLGTPIIVSVAGRTVEDFTELARRVGQCDGVSAIELNLSCPNVSGGIDFGTNAESCREVVASARNACDVPILAKLTPNVTRIADIAQGAADGGADAVCLINTVLGMAVDWKKRRPILGNGMGGLSGPAIKPIALRCVHQVRQAVDIPIIGIGGVANIDDVMQFLVTGASAVQIGTANYYDPTVSMRLIDQLPAALEELNATNLSDIVGTLA
The following text describes a protein:
Function:
Regulatory subunit of glucosidase II. May be required for defense response elicited by pathogen-associated molecular patterns (PAMPs) (By similarity).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MGLHAILLLLLLRISASAAASRPPLDTLGIPPQDEAYFRGGVIRCRDGSGRFARDKLNDDFCDCPDGTDEPGTSACPEGKFYCQNAGHSPITIFSSRVNDGICDCCDGSDEYDSNVTCKNTCWEAGKAARDKLKKKVATYKSGVVIRNQEIQKAKVAFAKDEAELAKLKGEEKILQGLVDKLTEQKKLIEKAEEEERLRKEKEEKRMKEEAEKQAADEKKASDASQEVDSQENHETVQEDESKVAEHHDGHATSHDNHTPESESSVEQHDPESQDDISIKAAPADESPPEETSAAPTKEQESTPADSEGLSREELGRLVASRWTGEKVDEVSKDDKNEHEAEHDMPEHSEETHEDESDVPESAEDSYAGYHSEVEDDRHKYDDEDFSHESDDEYVDDHDEHVASYKSDDDQKGDDHSDFTASGQASWLDKIQQTVQNVLRTFNFFKTPVDLSEASRVRKEYDDASSKLSKIQSRISTLTDKLKHDFGKEKEFYYFYDQCFESKEGKYVYKVCPFKKASQVEGHSTTSLGRWDKFEESYRVMQFSNGDRCWNGPDRSLKVRLRCGLNNELNGVDEPSRCEYVAVLSTPALCDEQKLKELEQKLKASSNQRDHDEL
The following text describes a protein:
Function:
Endoplasmic reticulum (ER) membrane-resident kinase/endoribonuclease involved in unfolded protein response (UPR). Initiates the selective decay of a subset of ER-localized-mRNAs that is required to survive ER stress. Rather than relying on a transcriptional program to up-regulate genes that enhance ER protein folding capacity as in S.cerevisiae, S.pombe cells reduce the amount of specific proteins entering the organelle by decreasing the level of ER-targeted mRNAs using ire1-dependent mRNA degradation. The sole mRNA cleaved upon ire1 activation that escapes decay is the ER chaperone bip1 mRNA which is more stable and hence is present at an increased steady-state after ire1 cleavage. Promotes ER stress-induced ER-phagy and via up-regulation of the protein level of the ER-phagy receptor epr1 (Ref.5).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MKSLKGRLLFLRKFVFFSLLILLFAHGASSSSSSFNYFDKRTNGKANNELALFSPTADSPSSVDGVLELPSAENVFAESSLYNAFIVATVDGSLHSYDRITGQELWSLFTNANPGLSYTKDENSLLSSKFLSQSNFKSYNSTHGEFYSDSTLNISYLSDDDTVWFVEPIDGGILYAFNLQTGLVRLPHSIKDLVHASPIRLLNNNVFVGSKNTTLFTIDVSNGDIVSQYPSGHRYETHHSVHNLGTKRDSVPSGADSDLSFKDPSGKKLSESLDLLDDFNYQVTVSNKSFVDIARTEYFITIYSDSNVILDLVYIDWTPTKNEIMYESFHSSSFDSKLALSSYDSSLHIVDTHSKFIKQNIPLMSPAATVFDIVTLPHNKKIDKSQTPAKFPTSVLLRQPIDTYLETMFPQIARNKTEHVYINHIGNAWFAMSERHYPLVSLAPEASFLYYNGFYIPLNSIFGLHSLMATPKPFFALPGLPGYDIPSYVESEGSTKTLPSIGKKPIPLLDPNPISSTPISITFWVIMFLSVSFTIVTFFSILRIRSSEVRPLKSQKNTVSINNKIDTSKRRRKGKRRKRVSDEHSASSNFNEIESQASFEQNQTLDILSENIVEIQDKSTDPLQKSLDSSLKSHLPEATVIQNTDGSVTVNSLTVYPEVIGYGSHGTIVYRGVYEDREVAVKRVLMEFYDLASREITLLQQSDNHPNIVRYYCKQKSDQFLYIVIELCKCNLSDLIEKPIAYDDLFKSIDLVSLLYQIAFGVSHLHSLDLVHRDLKPQNILLVVNNSPNLSKTRVRALISDFGLSKKLDFNQSSLRNTTFEAAGSYGWRSPEILSGSLSQQSKEIQVKTREGRIRQASHATDIFALGCIFYYTLTGGMHPFGSHYDCEGNILKGNYCLVHLQSLGECGVLAADLIEDMIAFEPSKRPTIEVVLNHPLFWDYAKKLDFLIDVSDRFEVEERDPPSPLLQMLENNSKSVIGENWTTCLHSSLVDNLGKYRKYDGSKILDILRVLRNKRHHYQDLPESVRRVLGDLPDGFTSYFVEKFPMLLLHCYHLVKDVLYEESQFKRYLEY
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MKPPPPALQDGVANDMENSEASAAAVRDVLRGRGEESSGSCETVAKAEEELQPLDTANGNYASSSALEENRASLAQAWRLGTPARKKLLILDLNGILVACHKKLDRSIGGDELCIQAAVLMEANVRKILDYIGEGLQHKVMFVMHQGDCTATGFKNPTNRRQPLFLKELAKVWSRFPDGEFNETNTLLIDDTPYKALLNPPHTAIFLKPYTYNEQDNFLAEGLVGYLTHLRNAADVREFVRMHPIGMPAIAAGCMHWNLYRSVLEKIKEVTDASTHRIASGNLEPRPHFSSTAEALVLEESVRNLSLH
The following text describes a protein:
Function:
O-acyltransferase that catalyzes D-alanylation of both teichoic acid and lipoteichoic acid (LTA). D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Catalyzes D-alanylation from DltC carrier protein.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHNLFDQKYLSVQLISFIIYVVWQVLLIMFYYHSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGHQIHFHESKLIEFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVWKLIQFISFFPTISSGPIDRYKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNLWLYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFWFRDCIYMRSLFYMSRKKLLKSQFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHAALFIGYGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSGKLI
The following text describes a protein:
Function:
Involved in the degradation and assimilation of the plastic poly(ethylene terephthalate) (PET), which allows I.sakaiensis to use PET as its major energy and carbon source for growth. Likely acts synergistically with PETase to depolymerize PET. Catalyzes the hydrolysis of mono(2-hydroxyethyl) terephthalate (MHET) into its two environmentally benign monomers, terephthalate and ethylene glycol. Does not show activity against PET, bis(hydroxyethyl) terephthalate (BHET), pNP-aliphatic esters or typical aromatic ester compounds catalyzed by the tannase family enzymes, such as ethyl gallate and ethyl ferulate.
Miscellaneous:
MISCELLANEOUS: The calcium ion is located far from the active site and appears to have a role in stabilization of the lid domain.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MQTTVTTMLLASVALAACAGGGSTPLPLPQQQPPQQEPPPPPVPLASRAACEALKDGNGDMVWPNAATVVEVAAWRDAAPATASAAALPEHCEVSGAIAKRTGIDGYPYEIKFRLRMPAEWNGRFFMEGGSGTNGSLSAATGSIGGGQIASALSRNFATIATDGGHDNAVNDNPDALGTVAFGLDPQARLDMGYNSYDQVTQAGKAAVARFYGRAADKSYFIGCSEGGREGMMLSQRFPSHYDGIVAGAPGYQLPKAGISGAWTTQSLAPAAVGLDAQGVPLINKSFSDADLHLLSQAILGTCDALDGLADGIVDNYRACQAAFDPATAANPANGQALQCVGAKTADCLSPVQVTAIKRAMAGPVNSAGTPLYNRWAWDAGMSGLSGTTYNQGWRSWWLGSFNSSANNAQRVSGFSARSWLVDFATPPEPMPMTQVAARMMKFDFDIDPLKIWATSGQFTQSSMDWHGATSTDLAAFRDRGGKMILYHGMSDAAFSALDTADYYERLGAAMPGAAGFARLFLVPGMNHCSGGPGTDRFDMLTPLVAWVERGEAPDQISAWSGTPGYFGVAARTRPLCPYPQIARYKGSGDINTEANFACAAPP
The following text describes a protein:
Function:
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
Subcellular Localization:
Cytoplasm. Lysosome. Lysosome membrane. Nucleus.
Sequence:
MSIEYEEQLAGSLVDSFPKDFGYGVENMDMMQENLENSPSADNKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISGSSFVNFHIWDFPGQVDFFDPTFDYEMIFRGTGALIFVIDAQDDYVEALGRLHLTVSRAFRVNPEINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADASLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKDEGNGNAYDKESLAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVSGSTQRMGGATVQSSPPSCSGNGLSRLKSTALNGTPRSLV
The following text describes a protein:
Function:
Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVLTRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYSLRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDNICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGLS
The following text describes a protein:
Function:
Protein tyrosine phosphatase that acts as a repressor of the yeast-hyphal switch. Plays an important role in virulence. Negatively regulates CST20-HST7-CEK1-CPH1 filamentous growth pathway. Represses hyphal genes such as SAP4, SA5, SAP6, and HYR1, by acting through a CEK1-independent mechanism.
Sequence:
MTTPLSSYSTTVTNHHPTFSFESLNSISSNNSTRNNQSNSVNSLLYFNSSGSSMVSSSSDAAPTSISTTTTSTTSMTGASANADNQQVYTITEEDSINDINRKEQNSFSIQPNQTPTMLPTSSYTLQRPPGLHEYTSSISSISSTSSNSTSAPVSPALINYSPKHSRKPNSLNLNRNMKNLSLNLHDSTNGYTSPLPKSTNSNQPRSNFIMDSPSKKSTPVNRIGNNNGNDYINATLLQTPSITQTPTMPPPLSLAQGPPSSVGSESVYKFPPISNACLNYSAGDSDSEVESMSMKQAAKNTIIPPMAPPFALQSKSSPLSTPPRLHSPLGVDRGLPISMSPIQSSLNQKFNNITLQTPLNSSFSINNDEATNFNNKNNKNNNNNSTATTTITNTILSTPQNVRYNSKKFHPPEELQESTSINAYPNGPKNVLNNLIYLYSDPAQGKIDINKFDLVINVAKECDNMSLQYMNQVPNQREYVYIPWSHNSNISKDLFQITNKIDQFFTNGRKILIHCQCGVSRSACVVVAFYMKKFQLGVNEAYELLKNGDQKYIDACDRICPNMNLIFELMEFGDKLNNNEISTQQLLMNSPPTINL
The following text describes a protein:
Function:
Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
Sequence:
MIILSGGTGTPKLLDGLKEILPLEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKKWWGIENDTFRTYERMHELGIEESMKLGDRDRATHIIRSNLIRGGTSLTEATVKLASLFGIDANILPMSDDPVSTYVETLQGVMHFQDFWVGKHGDPDVLGVDIRGVSEASVAKKVLEAFEKDDNVLIGPSNPITSIGPIISLPGMRELLKRKKVIAVSPIIGNAPVSGPAGKLMQACGLEVSSMGVAEYYQEFLDVFVFDERDRADEFAFERLGCRASRADTLMTSTEKSRELAEFVVGLFDTVC
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDIEDLASGGLFDEPKDFYKPEEQPGSDSYARQEKHVAASEYKEPTNFNLRLTAKNPLWGHLLWNAGKVTSDYLDEHSKELVEGKKVIEFGAGAGLPSLLCHAVGAKQVVITDYPDADLLYNLKYNVDQLKKDWDAKNADFSGPSPCADVSSMKVEGFIWGNDASELIEMSGGTGYDLVILSDVVFNHSEHAKLVRSAKELLAPGGKVFVVFTPHRAKLFNEDLDFFRRAKDEAGFESEKLFELKYYPMFEEEEETKELRSMVFGYMLTLKE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQEVPPSCGKTPEFTLGTHSPFHFDANAPGLANRKRPAPRVFRSWELSNQRQWGVASRSLSSSPAAGLQDSLVFEDVAVDFTPEEWALLDGAQRKLYRDVMLETFRNLVSVDNEIQLKTNGSISQRDIFEEKLSNEQKIARFTKNDSWTSLLGESWEDQCIEDKHNNQGRHLRNHMVERFCDSSKGNKYRETFSHIRNRKLYRKISTRLKLYECSQCGKVFRHRSSLKRHKRSHTGRKLYQCEECGKAFSCSSYLRNHVKTHSGEKPYACELCGKTFIRSHSLTGHIRSHTGEKPYECKECGKAFSCPKSFRVHVMMHTGGKPYECKQCGKGFSCPKSFRVHMIMHTGEKPYECKQCGKAYCWLTSFQRHVRIHNGEKPYKCEKCGKAFGWPSSLHKHVRMHTGEKPINVSNVGKLSPGPHPSKNIRMQTGEKRYKCEKCGKMFGWSSSLHKHAKKHTEEKCINVSNVGKPSGDPHPSKNAGMQTREKPYKCEKCGKAFGWSSSLHKHVRKHTGEKPINVSNVGKPSTGPHPSKTVRMQTREKPYACEKCGKDFSCPKSFQGHVRTHSGKKTCKYK
The following text describes a protein:
Function:
Responsible for microtubule translocation. May be important for the organization of phragmoplast-specific arrays of microtubules. Plays an essential role in stabilizing the mitotic spindle. Required during mitotic cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
METSEGKDTSQCVRVAVNIRPLVTSELLIGCTDCVTVIPGESQVQIGSHAFTFDYVFGSGGYPSSRIYDECVLPLVDALFHGFNGTVLAYGQTGSGKTYTMGTNFNGEEQTAGVIPNVMNTIFSKVEVMKESTELLIRVSFIEIFKEEVFDLLDGPARVPIQIRETVHGGITLAGVTEAVVRTKEEMASFLMRGSVSRATGSTKMNSQSSRSHAIFTITLEQKRMANCSMNDDGDDILCAKLHLVDLAGSERAKRTGADEMRLREGIHINRGLLALGNVISALGDEKKRKEGAHIPYRDSKLTRLLQDSLGGNSKTVMIACVSPADSNAEETLNTLKYANRARNIQNKAIVNRDPMAAQMQRMRSQIEQLQAELLYVRGDCGAPLEELQILKDKISLLEASNVELRKELKERRISCEHLAKCAVDAQVERDRLILKIESAKNGRPWNEIDHSDQDLDLVKKYVTKIQQLEAELLHLQSSSSSKHGEPVDYLGLDYAELLSKDSCSEDSDIKSVDTSGEAEVEEKELEHSSLQEKLDMELKELDQKLEQKEAEMKRFTAIDTSVLKEHYEKKVHELEKEKSVLQKEIEALQRNLSNTSSNSDESAQKLKQDYLQKLNLLEAQVAELKKKQDAQSQLLRQKQKSDDAAKRLQDEIHRIKSQKVQLQQKIKQESEQFRLWKASREKEVLQLKKEGRRNEYEMHKLMALNQRQKMVLQRKTEEAAMASKRLKELLESRKTSRDMAGHAASAAGFQALMQAIEHELEVTVRVHEVRSKYERQMQERSRMANEVAELKLQNLSDCMSPSVRCSRISALENMLATSSSTLVSMASQLSEAEEREQRTFSGRGRWNQVRSLADAKNIMNFLFNLTSSSRCQLRDKEVECREKDAEIMVSKEKVVNLVRQLASQKSELRQLELQNSELIKQEKLMKLALEHHKGRTNNSGCNVQSNIDGHGYDLRQKGNRSSLLYSGGWNLEDMDTSDSDCDQGRTGTDYGTCCSCSKQSECKTSRCECRGEDVSCGVSCRCLPNKCSNRVVSKEDNQLPSLDTVGDEGNTLEIDETEKRQMLASQGAMLLQNALSEKPTEAKDKGETRRKALSDIGNTLAKSKAPKPDKRKKWGKSVIQLVPAPTASNADAPIKPSQSGSADASVTENKVNEIDSTSPLKLPRSMRSALTNGNNTLRERNSETSDPFDQITHPASATSPHRPANTSDGKEN
The following text describes a protein:
Function:
Binds directly to 16S ribosomal RNA.
Sequence:
MALRHKSAQKRHRQSLKRRAINRAKKSTIKTFSKKALVAAQGGAEDATAMQQRAESLIDKAAKGSTLHKNAAARKKSRLAKAINKAKAAQQA
The following text describes a protein:
Function:
Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid-secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of genes involved in the modulation of cellular cAMP including pde-4 which hydrolyzes cAMP and acy-1 which catalyzes cAMP formation.
Subcellular Localization:
Nucleus.
Sequence:
MDDNTATLTAIHQQQQSHNRFSNPLVCVGQLDHHSLLPEHSISSSLAPLTHNPYAFNYSIPLPPTDITTKLPKLELLSLDVKQEQDDNHLDTSSPTDSTGNGSTNGGKIQKPRRQRTHFTSHQLTELENWFSRNRYPDMACREEIAVWISLTEPRVRVWFKNRRAKWRKRERNYVIDNGQGTTKVTAQSLDPLGSLQNTFPQTLLQSSSSQLDDSAVTSSSFYGYGGAWQQNPYYSRNNQTTFNWQIKPQDQFQFQTIPMSPTTATSRFSTAANLAPLPTAQAAFSTSATSSNDKLKLMDGLSNSLSSSLGQPYQPCQYSGPL