lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPRDREYDQWGYSGTRRDGGGRYGYRDRSRDERDRFRDVRDRDRDRDRDRERDRGGYRQDPRDRRYSRSRERERRGSGSRDRSRDRSRDRSRDAHRPPPSGRPHQPSGHDSTKSSNSMSETSSTSQVTGTTPNTTNATPSQAEIDAKKAAKLAKVAEWKRKKELERSKSASASPAPSTAPASPKAGFSMSGLSGLRKATDQGQVKRKMFFGGDSDEEDAGRKPAKLLKKLGEKEGSGKSEGKGRGGSQSEAKNASEKNGAASEPAEVDPLDAYMSSLTLPTTTSVSIADSTPLENLNVWEQVDTLEKSQDPTLDLSALSKRKEIAIVDHSKQVYEDFRRQFYVESSELADMTEAETNELRLSLDGIKIRGKDCPKPISKWTQLGLPGPTMGVLNDLRYDKPTSIQAQAIPAVMSGRDVISVAKTGSGKTLAFLLPMLRHIKHRVGVETHTTTLSGASSHPLGVIITPTRELCVQIYRDLRPFLAALELTAVCAYGGSPIKDQIAALKKGTHIIVCTPGRMIDLLAANQGRVLSLSRVTFLVIDEADRMFDMGFEPQVLKLTQSIRPDRQTVLFSATFPKKMEQLARRVLSKRSSDSLGPIEIIVGARSVVASEITQFVEVFQNEKSKFPRLLEVLGKYFAQGFFDEQSEGRVGTGESAATPIPNPKCLIFVERQESADSLLKELIQSGYPCLSIHGGKEQADRDQAISDFKSGLVSVLIATSVAARGLDVKGLGLVVNWDSPNHMEDYVHRVGRTGRAGQKGTALTFLLSDQERLAAEISRAIKSSGNAPPAPVQLMTERFEFKVRSGTEKRHMYGFSGKGLERLQDERDATREHERRAYEGDEAGEAETESSTPAASTANTDIIPKPVIVVTPPDSKSPTTAYHTTLQINDFPQQARYRASSNTSVSRVIANTGCSITAKGEYYPPGRIPGPKDEPKLFILIEGTSERAVKLAHHELSELLVSGLVKGARYQV
The following text describes a protein:
Function:
NAD-dependent protein deacetylase.
Sequence:
MALFPRSAVPALRFWGLRGARAWTRWPRIPGGGWSISCFAGASSDTGGGDHSQKKFLLQDIAELIKTRACQKVVVMVGAGISTPSGIPDFRSPGVGYYSILQQYKLPYPEAIFELSFFFHDPKPFFTFAKKLYPGNYRPNATHYFLRLLHEKGLLLRLYTQNIDGLERASGIPDSKLVEAHGSLASATCTVCRRPYPGEDFWADVMADRVPRCPVCSGVTKPDIVFFGEPLPARFLLHLADFPMADLLLILGTSLEVEPFASLSDAVRSSVPRLLINRDLVGSLARNPRGRDVAQLGDVVHGVKRLVELLGWTDDIQDLIQRETGKFDGWDRL
The following text describes a protein:
Function:
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
Sequence:
MSLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTQLIERLGLRR
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAMTAAAAAPAMRLFNPSTFFQTLRTQRFGVPALNFAVPAAAISLLPSIPSLLEDIWEGILRAVPKKKTSHMKKRHRQMAGKALKDVTHLNRCPACGNLKRMHHLCSTCLGKLKGFMDRNGGSNAKAY
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. bS1m functionally interacts with the 5'-UTR of mitochondrial mRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MTLAELLGRSRIAQVANNHKPLTYTGKKFHPTHQIIETKPSTLYRQEWGLKSAIPSKIKSRYLVYNDLDTLERITTFEPRGGTQWNRLRFQEMGVPIVSNIGRQNPFFKYISRPEDESHAKLSLFKEMKGDTDISPAAMKKRLKKITALIRSFQDEFKEWLVENHPDELKLNSNKLEDYVVKFLNKKLETKTNKKFNTEIIGTGGLSYSLPGKLKNSPNGVIQRTVVPGRILNVVKENNDNKWLAAIGGFVADVVFFQSPPSSFNSMGDFIRMKTFLFEILEASMEKNGSVSMHARLLEPQNDKTREFFNKRPIYKPLTSRRARRPSVGNIQEANNLLNIIKGN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLGDEKEGTSAIPGFNQIQFEGFYRFIDQGLIEELAKFPKIEDIDHEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVSAGLIWKTSRNMQEQRIFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYQSELDHNGISVYTGTIISDWGGRLELEIDKKARIWARVSRKQKISILVLSSAMGLNLREILENVCYPEIFLSFLTDKEKKKIGSKENAILEFYQQFSCVGGDPIFSESLCKELQKKFFHQRCELGRIGRRNINWRLNLNIPQNNIFLLPRDVLAAADHLIGMKFGMGTLDDMNHLKNKRIRSVADLLQDQLGLALARLENVVKGTISGAIRHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTANFRIRDIHPSHYGRICPIDTSEGINVGLIGSLSIHARIGDWGSLESPFYELFEKSKKARIRMLFLSPSQDEYYMIAAGNSLALNRGIQEEQAVPARYRQEFLTIAWEEVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVPAIAEHEGKILYTDTEKIVFSGNGDTLSIPLIMYQRSNKNTCMHQKPQVRRGKCIKKGQILADGAATVGGELALGKNILVAYMPWEGYNFEDAVLISECLVYGDIYTSFHIRKYEIQTHVTTQGPERITKEIPHLEGRLLRNLDKNGIVMLGSWVETGDILVGKLTPQVAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWVQKKGGSSYNPEIIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFECSLGLAGSLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRIFDGRTGDPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPKPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEV
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MTEKLLLLKYILAFLVCSSFLQIVNNSPIRNVTPTKMVRTHENPWIEHWEIKKQRAISSWSYTDPEAWQHSFPTCGSNLQSPINIETASLSAYPKFYFGNYGNIDRMTVTNNGHTVLFSLPSSIPAESIPFITGGGLSNRYNFVQFHFHWGNDSSHGSEHRIKSKKYSAELHLVHYNTKYGSFSEATKYDDGLAVLGVLIKVGKKINSPFRAVVDQLNEVDEDGDETTLVNLISFKDLLPSRTTTFFRYSGSFTTPGCEEIIIWTVFDDSITISESQLSKFRLLKGRDSLTLVNNYRPVQSLSGRTVTYRSHSGCHITINWSHISSPIVDIYQYSTCVFSFYANSFLTILGVNL
The following text describes a protein:
Function:
Nucleotide sugar transporter that specifically transports UDP-galactose.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEEGSMFRSLLAILQWWGFNVTVIIMNKWIFQKLDFKFPLSVSCVHFICSSIGAYIVIKVLKLKPLIVVDPEDRWRRIFPMSFVFCINIVLGNVSLRYIPVSFMQTIKSFTPATTVVLQWLVWRKYFDWRIWASLVPIVGGILLTSVTELSFNMFGFCAALFGCLATSTKTILAESLLHGYKFDSINTVYYMAPFATMILGIPALLLEGSGILSWFEAHPAPWSALIIILSSGVLAFCLNFSIFYVIHSTTAVTFNVAGNLKVAVAVMVSWLIFRNPISYMNAVGCGITLVGCTFYGYVRHMLSQQTPGTPRTPRTPRSKMELLPLVNNDKLEGKV
The following text describes a protein:
Function:
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (By similarity). May be implicated in the control of meiosis. Involved in cilium assembly (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the pericentriolar material (By similarity). Localizes to centrosome during interphase and mitosis.
Sequence:
MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTLSKFGPQPLPGKRPASGQGVSSFVPAQKITKPAAKYGVPLTYKKYGDKKLLEKKPPPKHKQAHQIPVKKMNSGEERKKMSEEAAKKRRLEFIEKEKKQKDQIRFLKAEQMKRQEKQRLERINRAREQGWRNVLRAGGSGEVKASFFGIGGAVSPSPCSPRGQYEHYHAIFDQMQRLRAEDNEARWKGGIYGRWLPERQKGHLAVERANQVEEFLQRKREAMQNKARAEGHVVYLARLRQIRLQNFNERQQIKAKLRGENKEADGTKGQEATEETDMRLKKMESLKAQTNARAAVLKEQLERKRKEAYEREKKVWEEHLVARVKSSDVPLPLELLETGGSPSKQQVKPVISVTSALKEVGLDGSLTDTQEEEMEKSNSAISSKREILRRLNENLKAQEDEKEKQHHSGSCETVGHKDEREYETENAISSDRKKWEMGGQLVIPLDAVTLDTSFSATEKHTVGEVIKLDSNGSPRKVWGKNPTDSVLKILGEAELQLQTELLENTSFKSEVYAEEENYKPLLTEEENLQCISKEINPSATVDSTETKSPKFTEVSPQMSEGNVEEPDDLETEVLQEPSSTHTDGSLPPVLNDVWTREKEAAKETELEDKVAVQQSEVCEDRIPGNVDQSCKDQRDPAVDDSPQSGCDVEKSVQPESIFQKVVHSKDLNLVQAVHCSPEEPIPIRSHSDSPPKTKSKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVHQDSLEIDELEDEPIKEGPSDSEDTVFEETDTDLQELQASMEQLLREQPGDEYSEEEESVLKSSDVEQTARGTDAPDEEDNPSSESALNEEWHSDNSDAETTSECEYDSVFNHLEELRLHLEQEMGFEKFFEVYEKVKAIHEDEDENIEICSTIVENILGNEHQHLYAKILHLVMADGAYQEDNDE
The following text describes a protein:
Function:
Major facilitator copper-regulated transporter; part of the crm gene cluster that mediates the biosynthesis of a yet unidentified copper-responsive metabolite. In contrast to crmA, is not involved in the biosynthesis of fumivalines or fumicicolins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAATTEKDLTARTTANIEAASDTVSLEEKSEREILERPNEITQDAQIGVQKAEATALVWSKTALYATYAWIWVCFFILNLQFSISNNMIYYAYAGFSSAPQISQAYILSTIIGGVLQLPIAKTLNLWGRAEGFLVFVGVLIVGIIVIASCNGPNGFAAGYTLYWIGYTAVNFILVVFVADASGLRNRAFAYAFIGTPTICTAFVGPLAAQAFYAHSTWRWAYGCFAIVIFFTFVPLALVFKFYQRKAEKTGVFVRDPSGRTPLQSFRHYFREFDLVGAFLLMAAFVLFLLPFSLETYGFSGYSSATFISMVVIGVLLFPVFAIWERFFAPTAFIKWQLFKNRTVLGACILAAVIFFNYYTWDQYYYYYLQVVYNLNTANTGYMTQIYSVGSTLWAVLFGIWIRQTKHFQKTCLYFGAPLMLLGAGLMIHFRGAESKIGYLVMCQIFIAFGGGTLVIGDEMAVMAAADRDGVPMMIAMISLAGSFGGAIGYAVAGAIYANTFPQALLRGLPDDLKGDSATVYLGGSTAQVMYPPGSAARNAINHAWTESQKYECITATAVVVLAFPAIAMWKNYNVDRKQVKGTVI
The following text describes a protein:
Function:
Involved in the export and assembly of a fimbrial subunit across the outer membrane.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MLKKTLLAYTIGFAFSPPANADGIEIAAVDFDRETLKSLGVDPNISHYFSRSARFLPGEYSLIVSVNGEKKGNIATRFDENGDICLDQAFLQQAGLKIPSEEKNGCYDYILSYPGTTITPLPNQEALDIIVSPQAIIPIGLDLTNAATGGTAALLNYSLMSSRAEFSNGSSDYSQAALEGGININDWMLRSHQFLTQTNGTFSNQNSSTYLQRTFTDLKTLMRAGEVNLNNSVLEGASIYGIEIAPDNALQTSGSGVQVTGIANTSQARVEIRQQGVLIHSILVPAGAFTIPDVPVRNGNSDLNVTVVETDGSSHNYIVPSTLFNQHVESFQGYRFAIGRVDDDYDESPWVISASSGWNLTRWSAMNGGVIVAENYQAASIRSSLVPLPDLTVSSQISTSQDTKDSLQGQKYRLDANYNLPFSLGLTTSLTRSDRHYRELSEAIDDDYTDPTKSTYALGLNWSNSILGGFNISGYKTYSYDGDNDSSNLNINWNKAFKHATVSVNWQHQLSASENNEDDGDLFYVNISIPFGRSNTATLYTRHDDHKTHYGTGVMGVVSDEMSYYVNAERDHDERETSLNGSISSNLHYTQVSLAAGASGSDSRTYNGTMSGGIAVHDQGVTFSPWTINDTFAIAKMDNNIAGVRITSQAGPVWTDFRGNAVIPSIQPWRTSGVEIDTASLPKNVDIGNGTKMIKQGRGAVGKVGFSAITQRRALLNITLSDGKKLPRGVAIEDSEGNYLTTSVDDGVVFLNNIKPDMVLDIKDEQQSCRIHLTFPEDAPKDVFYETATGECQ
The following text describes a protein:
Function:
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
GKSQSTKWASRPKIYIVIFACLMFKHLVHKPSEEKVKEIIVSAVRIEQEFLTEPLHIKLIGMNCTLMKQYIEFVADRLMLELGFSKIFRAENPFDFMENISLEGKTNFFENRVGEYQRMGVMSSPTENSFTLDGDF
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MIISPATRPTPMETPAIALAGTGTIIQPETSLAEFTTYRVGGKAEWYAAPRCLEDLVAVLDWFQGQDLPLTFLGAGSNLLISDQGLAGLVLSTRYLRQSKFDEEQGLITVAAGEPIAKVGWQAAKRGWQGLEWAVGIPGTVGGAVVMNAGAHNQCTAETLVEATVMRPDGGLEVLTNEQLGFSYRTSNLQKHLGDRLVVDATFKLTPGFTREEIMGCTTRNLHQRKSTQPYDKPNCGSVFRNPTPLYSARLIEELGLKGYRIGGAEVSQRHANFIVNIDNAKAQDVFNLIFHVQGEVEKHYGILLEPEVKMLGEFAR
The following text describes a protein:
Function:
Involved in lipid droplet (LD) organization. Modulates triglyceride (TAG) storage by reducing DGA1 LD localization. Promotes LD targeting of some proteins, including PDR16.
Miscellaneous:
MISCELLANEOUS: [Isoform LDO45]: Produced by splicing, generating a hybrid transcript with downstream ORF YMR148W. Splicing excludes the sequence coding for the last 29 amino acids of the originally predicted YMR147W ORF and includes a 210-bp intragenic region 5' of the YMR148W ORF and the entire YMR148W coding region. The originally predicted intronless YMR147W ORF is not expressed in detectable amounts.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet. Note=Contains a predicted membrane hairpin, a motif allowing association with both ER bilayers and LD monolayers.
Sequence:
MAARNRRKNNKKKSLLVTSAAQEKNATYVLVAEELHKKTIDLNMGTETPLTENHENPIPAKEFKHQQKLEPIDEHDDGEDELSIKFKSMTKSSGPITEAEVQKLLLSYAFTSAAIQEDENEKESRHYPIKPPSPSASSLSAYFQSFVEKCKQVFYNFSLQTVEKLNALQNSLYEVFWIIFIYLNYWFPNVGDYVSNTFGQQDSIIIRISLSKSHFRALREKSSQKVQQAVKNIYFCFQEKPYLTAFKVSFAIGLVIPCSLLFLIMVSTATFFFFVYLTLFVVIGFFSSLFIIPLLGISFVFAIGVVSFGFCSNMSFKMAQLIYVRADAFLKKVLDKMALQTQPAQLQEPQEPLSTLRPVSNPTIPSPLRQTARPSKFVTEEDVIFEPVSAQSAIARSLETTANKAGNKFQLS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MVEVLLMQHLTNPKLEMKEMEKKQITDQILKHALGIIYLLTEEASLLQHIIDSLLIKERNNKQLSERILNHALGIIYLLSGEEYAIVKKNSPHSSIHHLTGEVPITSGDVSIYFSMDEWDYIEGHKELYKDLMEKYQNYSAVEISDIQKSEIQDENTNNMCLTHSKETEEENDLVEAEIESNICSDECTAGLVSDVEDTEQPSLKKENESPELVAQETTSTWQSILEDGSVSRNILSPHSASRLSDKKLENITSTSPMFQGKHQEQNLPADSTICNTENCTSSSISYQCSKTKAQETGNVEWNSIEVKLEMSSDSESSSQEQSCRNFQSLHEDETEGEKIHKCNVCGKQFGYKCYLTVHLRTHTGEKPHKCDECGKYIASKAKLIIHQRTHTGEKPYSCKECGKQFRSKPYLVEHMRSHTGEKPHRCDDCGKQFAYKSRLIVHQRTHTGLKPHRCYQCGKHFDYVCYLIRHLKTHKW
The following text describes a protein:
Function:
Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MQHMDDPPDGGWGWMVVLSTFLVHVIAIGSYRSFGVFYAEFREVFQENAGNTSFVSSVYIATQLMCSPIASALSNLTSCRTVAMTGGVISAVGLGLSFFAQNAVHLIITIGLITGFGNSLMLSPSLAMVGKYFHKRHATANGIAISGSGVSLFILSPLFQFLIDEFGWKGALLIFSGIVLNGCVCGALLRPLRLKDAGKDGENEEEDEEAADSSKTCKAIIPFCHKVLKMFDVTLLKSRPFLVYSLSLFGLTLGNSMIFVHLVAHAQGLGVEKTQAAFLPSILGIVEAVVRPVNGWLSDKLPVRKLHYYMVGCVGLGICNIAIPHSRTYAALVACMVFYGISSGTFYPLIAVLVRKYSGISRISGGLGWAFVFQGAAYLLGQPIAGWLYDATGNYDMSFYAAATFIFVSVAVLLLLVPRKGKSWALESGKPAPDVPHDKCDGVVGLKARQLPVNTDNLTTGGQKNPAFKSEM
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MKLNTALEYCCMLQRTKLSMSWRSGSLSRTCKIITLYAKFIHSDKQMSSIKLNGLLYWNVCSPTFIKIVKKKTVADYSGFPYVCTLLNCLLWVVYGLPVVEFQVLVVTINAAGCFIEFLFLTLYLLNAEKKIRMKVMKLLMLVLVSFIAVTVLVLELIEDKKKRKTVIGTLCAVFAVGMYASPLSIMRMVIQTRSVKYMPFLLSLFNFINGLVWFGYAFIGGVDIYIAIPNGLGAASGIAQLALYAFYRNATPRDGDEKGNPTKATNNNFASIELEKNGAQKQSSHVSKSQTNEIV
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MRLYLVCVLLLVSCGLLGVIGRSVIKKEGQPKKQSTLDKEVLFEDEDYEDDDVLDLPPEEQKSRLKSLVEKKMDVNQDGFVDREELVQWSQKSLNRFETEASREEFSSVDENEDGKVTWEEYSSFLYGEDFAIDHEDFKNPQSDEWSGFVDRYNREKVMFAAADDNTDHGLTLDEYIDFKHPQFNPKTKRLLLNETLSRVDLNMDGGISLEEFLADYKKNNKENDQDWKIVETDKFKEDLDLDKDGLLKGEEVVMMVATDNFKEAEDEADHLIEETDEDQDGKLSPDEIVNNHELWVESDATDYGRQLMLNHDEL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLNRSLLFRNLRLARPRPFLPLVGKRFVTEKSQSQEEKDTSKITENAKEEVKRDTSSLAKESLKLLDLNGLNDESYTGDPGKGPEYTSSTMLKREKQARYAFWGFLGLTGGGLLYYGRRYGPDEKELEKQYPAAGYSPSDWWNRVKARTNNFFSYYQEPAFEKLLPDPLPEPYNRPYTLVLSLDDLLIHSEWTRQHGWRTAKRPGLDYFLGYLSMYYEVVIFTRQYLATAKPIIDKIDPYHVSISAVLTRESSKYEKGKVIKDLSYLNRDLSRVIMIDTNPESWSKQPDNAIAMAPWTGNPKDKELVGLIPLLEFIAIMDIKDVRPVLKSYQGKNIPLEYARREEKLRTKLIEDWNEKKKKGSSFLFGGRSVSEEPPKLIIDIQRERQKAAYAEFKKYIDENGPKMLEEEKAREAEQKTSIFNLLFHPEEVQQQQLEQMQQQQFSPETNASK
The following text describes a protein:
Function:
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
Sequence:
MANPHRPLHPRSSNGLVPDARSEEWKSSTKRETLGVLEHELQRLLATSHEAKLDLNRKELSGFRNLFSRFLRAKTFVDWSKIQPLPEHAIQPYGTLPGYDKAAIATMLSKLVVVKLNGGLGTSMGCKGPKSVISVRNDLTFLDLTMQQIQTLNKTYDVDVPLVLMNSFNTDDDTQKLLKKYANVKVDVHSFCQSRYPRINKETLMPIVSDIESGDHEAAMPRLYCFLSNIDNMGATVDLSILNFVLNASAAGDAAPEFVMEVTDKTRADVKGGTLIQYENRLMLLEIAQVPKDYVDEFKSVSKFRIFNTNNLWVHLGAMKRNVEQQTLEMEVIVNPKHLDRGLDVIQLETAAGAAIKNFKGACGEYTVAPQKERGSGTVFFGRIFEWDAHWWLEVSKGINVPRSRFLPVKKTSDLLLLMSNLYDIDNGSLTLSGLRSFPTTPLVKLGSSFDKVKDFLGRFQGIPDLLELDHLTVSGDVTFGKDVSLKGTVIIIANHGERIDIPPGSILENKIVSGNLRILDH
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.
Sequence:
MAAEEGLVDGGIAGIVRALELIHNPSSTNELRREALQFVESQKQSSSAARNGFMLASRRENDALVRYFGLTLLDHVLRNTSFTATDEITNLRDIVLKLAESIQPEDPTYIRNKIPQLWAEVAKRSWGLDWLDMDQRLVQFWNASLVHKELVLLVLETLSDDIFYREDTVSSLRGTDLNRALVEICTPLAVFEQAYPERDNHVAIRCGNEGWLTRICEFLQQCIGSVQHSKEAKDAALKALANLKSVLVWSIPKAIHLSGCVPSIAGAFTCTDEQVLLAAVEALHALYSRSAYDIEGFQPLVHLMYETESLNVILKLFQWSIVSPEDIDDTKYTISKKLSEMVSYVAGFLEEKGFSIETSAGVDLPFFFHLMLNVVQHRSLTVSIPVLHIWSKLIANPKIGNLDVVINLIPPLLTICTERLVHWESLPADSEDPTVIFLNEDIDTVPEKHAFVGNYRRYCSSIIETIVQKRPEEAIPHILLGVDNNLDNLYSGVEPFTAKSFSKNSVPLMRADTQFAVVEATLKGYTKWVAVHGRMPQQDEQRRGQLENILETWAYKLMQRNFEDPILKQRIVKLVVDISARALDKTPSFALKVLEYTLMTRLPDQPEFPNYSEAVKELHGLASHELRRLATRYADYFSTFYDLLEPKIQEITMANRVDDKLHMEFTSILLIIMQRANNVDPFLRQSRLASFVEPIKQAWQDDEIRSKSSTFEGFCNLLGLQNVGPYMQSKHAQKLADWSEVPLDAEGKQVQEEMTQRFQQLPLRGTKTMMAVSTDKLKKADPPYEIACTLWHDLIPIILPTLLQLVSNAHAFHNPENWAGLPGDMWGIVERILTDRFWQAGISSGSRDEFYAKITASRTSLEGFASSVRGKVRAVRESCYSMLFSMSRLREHFYGFAELPGPLSQALFKDSSHLSSHQFSVLLNISRCIIDDCPVRFRSQFLPPMLSTLFVNIDRKVTSEWESIEQRKAGLGDGDLADEMKSESILRQLTYSAVIMVASLLDPQRGGMQPVQKSAALPIKLTLFYVDPDEEPTDPSAPQPLPALSDSIRHFVLSSTEIFEPVMLFCTHALRMRDTRCCSIITRVIRSILQDFAPPHNSQTVVTIREFISSEVLKACITSVHEPYFVDMQKDLAQLIASIWVLYGSSTPTPKALILSLPGMTEERVASTEAALVRSTSARQQRALVLDLLEGLRGVSIAEQGKILGSREERRKARSALQERYMSNEMEGQQTHKVDINDGPDLSGVADMFG
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGEGFSYKAGKYPSTSLLETNCAYLCPSDYAAVLGNEKSDNVYLERNGHVVLLRPGRGSGSVAAHHDPMPEVPQGVILLSTFHRTKWAAPLDNTPITVSRSKFDATARATTVVFMIKPMAKQQKPVTIDTAKLKVRITEKFVHLPLAIGQDLAISDGSDFFILGVVGMSGKNKEIVSDETTLAFYRDTEAIFQTQTKEIKLTGEYAVAEVSAVAKALMNLINDTPEKNEQGGITNAESLGIGGLNKQFKDIFRRAFMSRIFPPDKLAELGQTHVKGLLLYGPPGTGKTLTARKIGELLNARPPKMVSGPELLDKYVGGSEQKVRDLFSDAFEEWKERENASELHIIIIDELDAVCKQRGSKSDNTGTMDSLVNQLLAMMDGPDALGNVLVVGMTNRKELLDEALMRPGRFEVHLEIGLPDCRGREQILRIHTKNLVAAKSLASDVDIAHLAERTPNFSGAELAGLVRSATSFAMERAIEKTKSVGPNKLPNLNKVDVLVVAEDFERALGEVTAGYGQADRTLLDAAAPLSILKATGYESVVQQAVSFGEAVLNSSITTGAMLLAAPAAGTGCTALCSVIAKRLGCEFVRIISAEQLVMRTSTEYGRADLICQIFEAAYRVPRALIILDGIESIIQYTPIGFRFSSNVLQTLNALICRPAPPDHKLIVLGTTTCLTAMSDVGLASVFGQVCNIPSLTPDQALCALCEYAAVAPNLEEKRNATHQVSVKYYLQPNPVKYEAYAEYKLFLERQKQGIPITIRNVLLAYEMAKVTVRKDALSRNPNAQQAVITDSVMARTLNATLS
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MQRLCGIDEAGRGPLAGAVYAAAVILNPERPIAGLADSKKLSEAKRDALAIEIKAHALAWGIASVSAQEIDEINILQASLLAMQRAYQAMVEQFGLHATLIQVDGNRCPKFELPCEAIVKGDSKVAEISAASILAKTARDASLLVLDAEYPQYGFAQHKGYPTALHLA
The following text describes a protein:
Function:
Transcription factor that seems to function as negative regulators of virulence by affecting the capacity to damage host cells and to stimulate a pro-inflammatory response.
Subcellular Localization:
Nucleus.
Sequence:
MTSFLPVNNTSSPQTRPMEEVATAATPRPHTNVSATEENRSRTMNSGTEDATPLNLHKVQEDSASRTKPSLGHNGTSHGESDADRDGSDHDSDAAGNAPPSKKKKGQRFYCTDFPPCNLSFTRSEHLARHIRKHTGERPFQCHCSRRFSRLDNLRQHAQTVHVNEEIPGDSLAATGTRFQRQIRTDRVRPQGRARAGTGGSQGTHSRGHSRNLSTSSIASTTSTYSQPPELRRRPPPLIMANDGSARTRLGLDTMADIPTTPPGQVRGIPGPAVAVGSPYTPSHRLFAAGGNGSPHLASARPAAAHMSGFWDGKTAARRLSVPTSANPFASQQPNNYPPSLVGSATPTTAAYPPGGVFASPVSSTHSFSREENAYSAADADLRRRTWHPSTHFALPRPATSGLSHYQTPDTVDAPVNASGATEQPPRLPGIESFDKVVLHQRPLTPPVRRPSPMQIDSHRKPSPSYALGGGFNYSQPANRPAPPISGPGHRRGHVSWDMSLHTNLTGLHIRDKPLPRDASHWSQQTIAELQNVSSRPSSSYQQQVQESRGITGHSAYEKMQGWYGGHTSGSQATRTSPEDSSSSEGVHTPSTASLEYHPAIVHNSGYIESHPPSMACDTSHSACPPLSQFSDGYQPHVKPDPRPDFYHNASVRDSGMGRLEALVAVATSENKNTAKLYG