lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli.
Subcellular Localization:
Cell projection, microvillus. Cytoplasm, cytoskeleton.
Sequence:
MSGLRLGDHVWLNPTPADKTRVAIGGIIKETKPGKILVEDDEGKEHWIQAEDLGTLSSMHPNSAQGVDDMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTVEQVQLYYRHHVGELPPHIFAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIYFNASGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLLGMSAEEKKLLCLGTPSEYHYLTMGNCTSCEGRNDAKDYAHVRSAMKILMFSDSENWDLSKLLATILHLGNVEFMAAVFENLDSSDVMETPAFPTVMKLLEVKDQALRDCLIKHSIIIRGEFVTRPLNITQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVQRTIGLLDIFGFENFQKNSFEQLCINLANEHLQQLFVQHVFTVEQEEYRAESIAWDYIHYTDNRPTLDLLALKPMSVISLLDEESRFPQGTDTTLLQKLKSVHANNKGFLQPKNIHDAQFGIAHFAGEVHYHVEGFLEKNRDVLNRDILALVHSSQNKFLREIFGLESEESRRGPGSIVRVKSSSQQFKSADSSKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNDYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYSFEEFSQRFRVLLPSAVRTELRNKFRQMTLRIAERWLGTDKEWKMGKTKIFLKENQDTLLEVQRSQALDEAAIRIQRVLRGYTHRKEFLRQRRAAVTLQAWWRGHYSQQNFKLILLGFERLQAIARSHLLAKQYQALRQRMVRLQALCRGYLVRQQVQAKRRAVVVIQAHARGMAARRNFRQRKANVPLVIPAEEQKSPSAVPKRKRKSIYDTITDTEMVEQVFGFLPSLTGGQDSPATPDIEDLKEMTQKLPEVDLDTVPMMEEPEDDLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDYSAALAIWSIILRFMGDLPEPVLFTRNTLRGGSVMRQIHDALGKEGSTQPPQHSRSAQRPSRRDRGTKDISSMKLKRSSWVTGQVANQLNIGEEAFEEDSPLSDRPMSNLEKVQFIVGYAILRPDLRDEIYCQICKQLSENYKTSSLARGWILLGLCLGCFPPSERFLKYLLNFIGQGPVGYGPFCAERLRRTCANGVRTEPPSWLELQAVKSKKHIPIHISLATGESLMVMVDSASTSREVCLHIARKQGLSDHLGFSLQVAVYDKFWSLGSGRDHVMDALAQCEQLARERGESERQAPWRIYFRKEFFTPWHDSQEDPVSTHLIYRQVLHGVWLGEYPFEKEEELVELLAQHCYVQLGASAGSQAIRELLPSCVPSKLYRTKTPEKWASLVTTTYAKAPYTQKRARPLTVQEQVVDTACLKWPLLFSRLFEVTTLSGPQLPKTQLILAVNWKGLYFLDQKEKVLLELSFIEVMSLITNREARGGQRLMLSTLHEEEYEFRSPSSVAVAELVAMFLEGLKERSVFAMALQDRKATEDSTLLPFKKGDLLILTKKQGLLASENWTLAQNDRTEKTGLVPTSCLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGRPTEAPPEEQPEENLHTLEEFSYEFFRVPEKETVSRAVLPLARTRGQLWAHSAEPLRQPLLRRVHANAELRDAACQIFIAILRYMGDYPSRQAWTSLELTDQIFSSALQEAVLQDEVYCQILKQLTHNTKRYSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRRKVLAPDCSRRIQRVLRTGPRKQPPHQVEVEAAEQNVSRICHKVYLPNDTSEMLEVGANTRVRDACDSIAARLQLASWEGCSLFIKIADKVISQKEGDFFFDSLRQVSDWVKKNKPQKEGAPVTIPYQVYFMRKLWLNVAPGKDVKADTILHYHQELPKYLRGFHKCSREDAIHLASLIYKARFGDDRPQLASIPKILRELVPENLTRLMSPEEWKKNILLACNKHKDKTVEEAKVAFLKWICRWPTFGSAFFEVKQTSEPSHPDIILIAINRHGVLLIHPKTKDLLTTYPFTKIASWSSGSTYFHMVLGGLGRGSRLLCETSLGYKMDDLLTSYVQQLISAVNRQRAPRGSVPSHP
The following text describes a protein:
Function:
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSDSGKDTVATKEKDGAEKRGRGRPRKHPQEASGSPTPKRPRGRPKGSKNKPSSTVSRGKKAAAASAPAGTKRRGRPKKAEKEEQPSKSSEEEEEEEEEQ
The following text describes a protein:
Function:
Required for the assembly of mitochondrial cytochrome c oxidase.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTFGSPGALPTTKPTPPQRGSFPLDHDGECKHVMTTYLACIKRVKGVNEDECRSLAKAYLACRMERNLMAKDDFKNLGFKEDEPSSTPKPAAEAEKGVKGELRW
The following text describes a protein:
Function:
Necessary for the hydroxylation of but-3-enyl glucosinolate to 2-hydroxybut-3-enyl glucosinolate, which is toxic to insects, bacteria and nematodes, inhibits seed germination and produces bitter flavors.
Sequence:
MAENYDRASELKAFDEMKIGVKGLVDAGVTKVPRIFHNPHVNVANPKPTSTVVMIPTIDLGGVFESTVVRESVVAKVKDAMEKFGFFQAINHGVPLDVMEKMINGIRRFHDQDPEVRKMFYTRDKTKKLKYHSNADLYESPAASWRDTLSCVMAPDVPKAQDLPEVCGEIMLEYSKEVMKLAELMFEILSEALGLSPNHLKEMDCAKGLWMLCHCFPPCPEPNRTFGGAQHTDRSFLTILLNDNNGGLQVLYDGYWIDVPPNPEALIFNVGDFLQLISNDKFVSMEHRILANGGEEPRISVACFFVHTFTSPSSRVYGPIKELLSELNPPKYRDTTSESSNHYVARKPNGNSSLDHLRI
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MSYPYYTEFFVRYPKFKERDEKDRTVDPRIELEKKCAVKCVRPVNEYQNCVSRVRARTDNKGNCLGQYEELYICIDHCVAKDLFNYLA
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Potentially inactive.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSKQTYKVCFCFRRRYRHTVSVAPAEIKTLFDNYSDKGLMTTDLLLRFLIDVQKQDKATKEEAQDIVNASSSLLHRNGLHLDAFFKYLFAVTNSPLSSLEVHQDMDAPLSHYFIYTGHNSYLTGNQLSSDCSELPIIEALKKGVRVIELDIWPNSDEDGIDVLHGRTLTSPVELIKCLRAIREHAFDVSDYPVVVTLEDHLTPKLQAKVAEMVTDIFGEMLFTPPSGECLKEFPSPAFLKKRIMISTKPPKEYKAATDDDLVKKGRDLGDKEVWGREVPSFIRRDRSVDKNDSNGDDDDDDDDDDDDDDGDDKIKKNAPPEYKHLIAIEAGKPKGGITECLKVDPDKVRRLSLSEEQLEKASEKYAKQIVRFTQRNLLRVYPKGTRITSSNYNPLIAWSHGAQMVAFNMQGLGRSLWVMQGMFRGNGGCGYIKKPDLLLKSNAVFDPEATLPVKTTLRVTIYMGEGWYYDFPHTHFDRYSPPDFYTRVGIAGVPADTVMKKTKTLEDNWIPAWDEVFEFPLTVPELALLRIEVHEYDMSEKDDFGGQICLPVWELRQGIRAVPLRNQDGVKCRSVKLLVRLEFV
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNGFIAFMEKYFIPYAAKIGGQRHLVAIRDGFITTMPLMILGSFAVLINNFPIPAYQKFMNNLFGEGTWQAFGGNVWNGTFAILALLIAFTVAYNLAKSYDKDPLSSAVVSVATFFTIGAIAPGADGIANTGGLGSTGLFLALIIAILSTEIFTRLSGSPKLIINMPDGVPPAVSRSFAALFPAMITVSIFGLITAFFQAAGVTNLVISFYELVQEPFMGLANSLPAALLLAFVSAFLWFFGLHGANIIDPFMQTINIPAIEANVKALEAGKELPYIVNKPFFDSFVNLGGTGATIGLIIAIFIVARKHKAYMTVSKLSAAPGIFNINEPMMFGLPIVLNPIMFIPYILAPLVLVTVAYFATAIGWVPACTIVTPWTTPPIIGGALATQSIAGGVLAAVNLGLSILIFLPFAKIAQIQELRREKEALAAEGVTAE
The following text describes a protein:
Function:
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSSAFSGDETAPFFGFLGAAAALVFSCMGAAYGTAKSGVGVASMGVMRPELVMKSIVPVVMAGVLGIYGLIIAVIISTGINPKAKSYYLFDGYAHLSSGLACGLAGLSAGMAIGIVGDAGVRANAQQPKLFVGMILILIFAEALALYGLIVGIILSSRAGQSRAE
The following text describes a protein:
Function:
Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
Subcellular Localization:
Endoplasmic reticulum membrane. Golgi apparatus, cis-Golgi network membrane; Single-pass type IV membrane protein.
Sequence:
MARVGTALAGRGGGSCDRKPEAGRGAVRTCSVEAGAGPGGAGNMEPLYQQTHKHVHEIQSHMGRLETADKQALHLVENEIQASIDQIFSQLERLEILSSKEPPHKRQNAKLRVDQLKYDVQHLQTALRNFQHQRYAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKIHHGMDDLIGGGHSILEGLRAQRVTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT
The following text describes a protein:
Function:
In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts an anti-sigma factor and thus releases a sigma factor from inhibition.
Sequence:
MFPYKIVDDVVILMPNKELNIENAHLFKKWVFDEFLNKGYNKIFLVLSDVESIDSFSLGVIVNILKSISSSGGFFALVSPNEKVERVLSLTNLDRIVKIYDTISEAMEEVRRK
The following text describes a protein:
Function:
May play a role in the maintenance of the structure of mitochondrial cristae.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Domain:
Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure.
Sequence:
MPKSGRDGGASKDSKYDLSKISARVDRVNVSGLLRTHNDYVMRAADGLFKASNFQDLMLEAMSTKSYLHELGIFKDVSVHIDVSRGADASPQGYEVTFKGNEMSRMMGSAGTEIGQNEGSLRTELTIPNILGRGENISLQGSYSSTRANDLQLKFWKPFFHTRFKENRPEMSFSIFRQTDRFDISSFQTTNIGYLVDFSAHTMVGVDLTHSLQYENAIRDVGLLNKSVPFAIRDHCGPKLASLLRYSVVYDNRDGNVFPTRGIYLKSVNEYCGLGGNVAYTSSTAHGELNVPLFAGLVAQFCARVGVVKETKNTTQLPISSLFYCGGPLTLRGFKFGGAGPVVESTPIGAQSFWCTGAHLWAPLPFAGVFKNLASHFRMHFFYNIGNNNSFSTENMRSAFGMGLAVKLAERARIELNYCVPVRHQDTDRILNGFQFGIGYEFV
The following text describes a protein:
Function:
Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. PBP-2B is required for vegetative cell division and sporulation septation. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins, thereby interrupting normal cell wall synthesis (Probable). This protein itself, but not its transpeptidase activity, is required for cell division.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Localizes at mid cell, to cell division sites; localization requires FtsZ.
Sequence:
MPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANGEVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQHVVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGISFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESDKSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPKTGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKYKSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKFNFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKPYVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGFDVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSDPVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLTPIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIHIEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD
The following text describes a protein:
Function:
Plays an essential role in budded virion (BV) and occluded derived virion (ODV) development. Participates in intranuclear microvesicle formation, ODV envelopment, and subsequent embedding of virions into occlusion bodies.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MNLYLLLGALAIFSLVYDKKENSIFLYLLILFLVFIIVSPAIISKNTESTVEDIPSHKAKSVRKKLEIEQALDAILNKNTSSID
The following text describes a protein:
Function:
DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes. May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors. As an RNA-binding protein, involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as STAT3 and TBX21 (By similarity). Also stabilizes IL6 mRNA. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEEQEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQQGLASGSSVSFVGASGCPEAYKRLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQEEGCRHGAEPQASPAVHLPESPQSPKGLTENSRHRLTPQEGLQAPGGSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQHPRDFFSRLKDGVLLGPPGKEGLSVKEPQLVWGGDANRPSAFHKGGSRKGILYPKPKACWVSPMAKVPAESPTLPPTFPSSPGLGSKRSLEEEGAAHSGKRLRAVSPFLKEADAKKCGAKPAGSGLVSCLLGPALGPVPPEAYRGTMLHCPLNFTGTPGPLKGQAALPFSPLVIPAFPAHFLATAGPSPMAAGLMHFPPTSFDSALRHRLCPASSAWHAPPVTTYAAPHFFHLNTKL
The following text describes a protein:
Function:
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYITIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNSATLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKSNPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL
The following text describes a protein:
Function:
Endoplasmic reticulum (ER) protein that functions as a co-chaperone for BIP1 during ER stress. Might be specifically involved in the refolding of N-glycosylated proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Domain:
The TPR repeats mediate interaction with unfolded polypeptides and the J-domain is essential to stimulate the ATPase activity of the chaperone and to increase its substrate affinity during the folding cycle.
Sequence:
MKATLLPSLLALSLTLCLALGLSSSGVLVRADAFASSQPPVVSDPVLASQHLTQANVALQSGRYQDALSAFDLALQADPSSWLTYYRRATAQLSLGRTSAALQDFQSLLKLNPKFDKAYLQQAKVYLKEGDCDKAKQALKTYDSIRAEKGAANSSPAEANSVRSKLTLVETSIKSLGQLVKELDKAQKADKKGKAKELDSTKVDHCIHLAGEVLKISPSHLETRLVRARCQTMKGRIEDAMADWTRAVHLTPSPFLLRRLSVLSYFVVSEPGSQSRDAGLQHLKACLHSDPDNKSCAKMHRKIKALEKSLKKARNFYNSQSYRAVLSALKGGKVGRATVVDDIKEAIRSATEVQSGDEEPLIPSTYKGDPVQESGLLLELHTMYCKAYTELNDMDKAMPYCELVLAKDPDNVEATLARAELALQREDYDQAVRDLTKAFDASGRTDRAIHQKLQTAQKRLKLSQSKDYYKVLGVKRTDSLATIKKAYRKMARENHPDKGGSQEKMAQINEAWGVLGDEELRKKYDQGDDPNDPMGGQQGGYGNPFAQGGHPFDMFFQQQAGFGGFPGGGFPGGQQFHFKMG
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MNEQPNEELQSEDEQFDPQETVSFEGETAANDEAFAEAGEETRDEEMTRLRGEVEEASKRVLQAQAEAENFRKRLRRDTEAQLKFAGMPLVTDILQVRDNLLRAIEAATTAGDGESAAGLVEGVSMVRKQLDDVLAKHAIKEIPAEGELFDPNFHEAISQMPHPEIASGMVAHVATPGFQMHDRVVRPAQVVVSTGDGSA
The following text describes a protein:
Function:
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Sequence:
MSSSDGAPESWISSFCQLMGHEFFAEVSEDFIEDDFNLTGLQSQVPMYKEALEMILDVEPEEDEEEEEEEEEEEDEDEILGDEKPPGYRRERRHTRVASDLSMIETSAELLYGLIHQRYITSRPGIQQMLEKYELQHFGVCPRVHCNGCKVLPVGRSDTPGQETVKLFCPSCQDLYTPPNSRFHSVDGAFFGTTFGCLFFMTFPDLEIGPRFDAPLSNISPPRSASLPSTATTTTTTTTTSAGASNQVTSDTPRPVYPVELNGVRTVNFCPGLGEGRVYESRIYGFRVSERSRAGPRMKWLRMKPADITELDEMSRFKALQNYDDDGDADMGEDNAQNANSAIAQRKKAPMRRRRYNPDQMNINGVDG
The following text describes a protein:
Function:
Involved in cytokinesis. May hydrolyze GTP.
Subcellular Localization:
Cytoplasm. Cleavage furrow. Note=During cytokinesis, found in the cleavage furrow.
Sequence:
MSVFKKKDKSDDKKKKHDEETPQGTFQPASQSTSNTNLNSLASSVNNGASVGSTNGSTPNNSNGSTPTYNHNNSAEELEKQKKEEDEKRKKSELEAAAAVVAKKKEDEEKQRKEQVELERKRRDEEIRRTNAAAANAANKELNEQVEISSLEQMGKLDPSSTIHDMFSFFPNEVYNSYEKLQYFSRDLNTAVSHPEIVFVGPRSSGKSSLIEAFIGRALNIVGGGNIVGVGGSNANGCSKRVLYLQFTNNIDFEVPKVTIKKDNTIKEFDHDIIVSIEQLNENLAKRNQLTNDYIEEPIYVSIESRTTLNLTLIDSPGLLFDQSQAESNKIESIVSSLLRPSHRLIIAVESCSQDWKSMSMGQYLKKIDPELSRSTFVFTKFHHTVRGFSSTRDINKYLSGTVPDIKGFFVTLPNHQVRASYSEANRFQEKIYQAHKRDMHALEQLQYDKRYERTIGVAPLRRYILNIVWKSYQDTIPRILKHLRSKRQTAEATLNELQKQSSSLDSTKLRSIASNYTVTFLQITEKLLSGTSEGNPSANGQTLDEEKSQQGDCGEWVDAYKEAIYIDPEEWNIPYWSSKLYGGQQLERLMAEFKAVCDNSKISEVKMDDIATASGINKLNNIPNYAWAASDLTSLISRDTFVPLIEQLCERAMYIMKRLTDIADKVIDSRRKSRCIGSSPFGGNGLNNINSGGNNGININDRLSNTDMDSLDQYPFFTHHVKNLYYDFVHRAAKGCKEKCMDEFYSSRTIYWELTEHPDSSLPSIRNDHHETKTAVCQLATKLFDSIRQRITKNVLLKLYNFFLVPMQTDLWNEIQAQITCLSNEQLEQLFEVQATREQLKQEEKKQQQILEKYSQIDEQFLKAASLFCRPLSNPTPSA
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MASYRKQRIENDIIRLINRTIINEIYDPVVKLGHVSHVKLSADFFHAVVYLDCYDRSQIQTVVNAFKKAQGVFSQMLAQNLYLAKSVKLHFVKDDAIDNALKIEQIINSLKN
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAPEVLPKPQMRGLLARRLRFHMVTGFVLSLGVAALYKVGVADKRKKAYADFYRNYDAMKDFEEMRKAGIFQSVK
The following text describes a protein:
Function:
Segment polarity protein required for correct patterning of every segment. G protein-coupled receptor which associates with the patched protein (ptc) to transduce the hedgehog (hh) signal through the activation of an inhibitory G-protein. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium.
Sequence:
MQYLNFPRMPNIMMFLEVAILCLWVVADASASSAKFGSTTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWFDGLDSRHIQCVRRARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRCNETLFPTKCTNGARGMKFNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSITLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVSVRHVSVESRRNSVDSQVSVKIAEMKTKVASRSRGKHGGSSSNRRTQRRRDYIAAATGKSSRRRESSTSVESQVIALKKTTYPNASHKVGVFAHHSSKKQHNYTSSMKRRTANAGLDPSILNEFLQKNGDFIFPFLQNQDMSSSSEEDNSRASQKIQDLNVVVKQQEISEDDHDGIKIEELPNSKQVALENFLKNIKKSNESNSNRHSRNSARSQSKKSQKRHLKNPAADLDFRKDCVKYRSNDSLSCSSEELDVALDVGSLLNSSFSGISMGKPHSRNSKTSCDVGIQANPFELVPSYGEDELQQAMRLLNAASRQRTEAANEDFGGTELQGLLGHSHRHQREPTFMSESDKLKMLLLPSK
The following text describes a protein:
Function:
Binds the lower part of the 30S subunit head.
Sequence:
MIERTFVKENVKRLLIDEYFKKELSKAGYSHCDIRKTPIGTKIIIYAEKPGFVIGRRGSRIRELTETLAKEFGVEKPQIDVKPVENPDLDAQVVAQKVAQSLERGLHFRRVGHTAVRRVMNAGAKGVIVIISGKLTGERARTEKFMAGYMKHCGEPAEELVDKGRAIAKTKPGVIGVTVKIMRPDVLLPDEIIIKEDAEVKHVVEEEQ
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MASFEKAAKAGQRIHRERDQPSERRKFGHLEKHKDYLLRARNYQKKKEQLKKLQIQARDKNPDEFHFGMINDRVIGGKHVIAKDNNKQRPFKYRKAQVVEMRRIKTRELRAILLESADQKKTIEKLQCSLSLYENKTGFKKSNSHLRFYETTDEKKELMNSQDSTKDEIKLNAKNTKLSHYKKQLQARLNRLQELQKAERQLQSEILQMGQSAKKKMVKT
The following text describes a protein:
Function:
Heme-binding protein which promotes neuronal but not astrocyte differentiation.
Sequence:
MGLLGSSVSLLGVLLAVLGYLVWTGADLGPLNPLAQVVKPYLERFSTEEPPERLFTPQQLSKYTAKSGSPELYLAIMGKVFDVTKGERVYGLNGGYSFFVGRDGTRAFVTGEFTEAGLIDTVDGLGWRDLLGIEEWVQRYEKDYTYVGKLIGRYYDEEGNPTKELLDVDEKMKTAHSEKNAVEEHKRNFPPCDSMYTEEDGPKFVCTKESGGIERDWVGVPRKLYTEAGSDKYRCICVKNTGPPAGDPGAAQHSDRGDLDNPLVNLQEFDGCASDASACKP