lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine-protein kinase which regulates the localization and the function of the septins during mitosis. Phosphorylates SHS1.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Bud neck.
Sequence:
MAINGNSIPAIKDNTIGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPERRIKTRDILKHPLLQKYPSIRDSKSIRGLPREDTYLTPLSESNSSIDATILQNLVILWHGRDPEGIKEKLREPGANAEKTLYALLYRFKCDTQKELIKQQQVKKRQSISSVSVSPSKKVSTTPQRRRNRESLISVTSSRKKPISFNKFTASSASSSNLTTPGSSKRLSKNFSSKKKLSTIVNQSSPTPASRNKRASVINVEKNQKRASIFSTTKKNKRSSRSIKRMSLIPSMKRESVTTKLMSTYAKLAEDDDWEYIEKETKRTSSNFATLIDEIFEYEKYEQIRKEKEELERKVREAKAREELERRRRKQEEKERARKLLEKEDLKRKQEELKKQIEIDISDLEQELSKHKEEKLDGNIRSISAPMENEEKNINHLEVDIDNILRRRNFSLQTRPVSRLDPGIMFSSPTEEVSPVEPKRTENERLTTEKKILETIRRSKFLGSSFNIDKELKLSKMEYPSIIAPQRLSEERVVSDSNDGYESLILPKDGNGVSQLKDSTATTAPVSDGRLRKISEIRVPQFTRKSRHFSESNKRLSVLSMYSTKESFTNLVDILKNGNLDVNNQQSQRIPTPRSADDSEFLFETVNEEAEYTGNSSNDERLYDVGDSTIKDKSALKLNFADRFNGSNEAKQTDNLHLPILPPLNGDNELRKQNSQEGDQAHPKIKSMIPESGSSSHTEKEEENEEKEEKKPEQHKQEEDQEKREKVVDDMEPPLNKSVQKIREKNAGSQAKDHSKDHLKEHKQDKNTAIGNGSFFRKFSKSSDKTMELYAKISAKQLFNGLEKLLRGWTQYGLKNIKSHPNNLTLTGKLSSDNIFSLRSTLFEVNIYPRGKMSVVQFKKVSGSFKAVKKLVNEVENVLNKEGVLQK
The following text describes a protein:
Function:
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.
Sequence:
MNEWTKGRRNERGLEAAAPPLPSPLPSPLPSPPSPLPPPFPLPPPRRRASGAGPGALTSHPARRRARRAPGSRARAGRGGGREAPPFSGPGPAAAPHGPRAPRPTARPPPAPRPGGPGASAGAAAMPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGIKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI
The following text describes a protein:
Function:
Phytosulfokine receptor with a serine/threonine-protein kinase activity.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MVIILLLVFFVGSSVSQPCHPNDLSALRELAGALKNKSVTESWLNGSRCCEWDGVFCEGSDVSGRVTKLVLPEKGLEGVISKSLGELTELRVLDLSRNQLKGEVPAEISKLEQLQVLDLSHNLLSGSVLGVVSGLKLIQSLNISSNSLSGKLSDVGVFPGLVMLNVSNNLFEGEIHPELCSSSGGIQVLDLSMNRLVGNLDGLYNCSKSIQQLHIDSNRLTGQLPDYLYSIRELEQLSLSGNYLSGELSKNLSNLSGLKSLLISENRFSDVIPDVFGNLTQLEHLDVSSNKFSGRFPPSLSQCSKLRVLDLRNNSLSGSINLNFTGFTDLCVLDLASNHFSGPLPDSLGHCPKMKILSLAKNEFRGKIPDTFKNLQSLLFLSLSNNSFVDFSETMNVLQHCRNLSTLILSKNFIGEEIPNNVTGFDNLAILALGNCGLRGQIPSWLLNCKKLEVLDLSWNHFYGTIPHWIGKMESLFYIDFSNNTLTGAIPVAITELKNLIRLNGTASQMTDSSGIPLYVKRNKSSNGLPYNQVSRFPPSIYLNNNRLNGTILPEIGRLKELHMLDLSRNNFTGTIPDSISGLDNLEVLDLSYNHLYGSIPLSFQSLTFLSRFSVAYNRLTGAIPSGGQFYSFPHSSFEGNLGLCRAIDSPCDVLMSNMLNPKGSSRRNNNGGKFGRSSIVVLTISLAIGITLLLSVILLRISRKDVDDRINDVDEETISGVSKALGPSKIVLFHSCGCKDLSVEELLKSTNNFSQANIIGCGGFGLVYKANFPDGSKAAVKRLSGDCGQMEREFQAEVEALSRAEHKNLVSLQGYCKHGNDRLLIYSFMENGSLDYWLHERVDGNMTLIWDVRLKIAQGAARGLAYLHKVCEPNVIHRDVKSSNILLDEKFEAHLADFGLARLLRPYDTHVTTDLVGTLGYIPPEYSQSLIATCRGDVYSFGVVLLELVTGRRPVEVCKGKSCRDLVSRVFQMKAEKREAELIDTTIRENVNERTVLEMLEIACKCIDHEPRRRPLIEEVVTWLEDLPMESVQQQ
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MKNINLTKWRYISSAISIFLMLASLTIVCVKGFNWGLDFTGGVVTEVQLDRKITSSELQPLLNAAYQQDVSVISASEPGRWVLRYADTAQSHVDIAQTLAPLGEVQVLNTSVVGPQVGKELAEQGGLALLVAMLAILGYLSYRFEWRLASGALFALVHDVMFVLAFFSLTQMEFNLTVLAAVLAILGYSLNDSIIIADRIRELLIAKPKLAIQEINNQAIVATFSRTMVTSGTTLMTVGALWIMGGGPLEGFSIAMFIGILTGTFSSISVGTSLPEFLGLAPEHYQVQAITDTP
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Sequence:
MPVIAADKPLHLTSHDVVNRARRALGTKRVGHTGTLDPLATGVVVLCVDDSTKLVQFMEHDTKEYLAWVSLGAGTPTLDAEGPIEQQAEVPPLDEDHLREVLKGFLGPQQQIPPQYSAIQIGGQRAYAVARAGGQLDLPARDVEIHELELIGMFPSVQAAPRTFDPQSWTPAAAGLTFTLPEPLGEFPTLLLRAHVGSGTYLRSLARDLGAALGVPAHLGGLVRTRAGRYSLRDAVSLENLTEAPTIPDLDALDFPRIEADERLARELRQGKRPAHPQRGRAVVTLGGELVAVVDGDGEHLKVVRAWA
The following text describes a protein:
Function:
May be required for traffic between late Golgi and early endosomes.
Sequence:
MSFVGGGGCGGQDVHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSSQQNSVYYTVNQILYPLVQGCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIEEVKVLQTVTLLLTTNTVVHGDTLAKALVLCFRLHYAKNPTIVNTAGATIRQLVSLVFERVYLEKDSVSSLQQQQSSGSPAEGEGGNQDVQTFASDAFLLFQDLVQLVNADQPYWLLGMTEMTRTFGLELLEAVLTNFSAVFHESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNAPVPAEKPYFPISMRLLRLVAILIQKYHTILVTECEIFLSLIIKFLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDLKNHATNIVHDMIAAMGSYIRYSLINASAMLNGQQNGVANSLTAMSGSNQCGFMFRGAYLPLVATYAPGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDMTRSIGGVIQRTPELHPSHNTAVITEEEHKPLCLQLVNSSWSALLSAFIPLVETSIDEATTENILKAMQNYAALCGMLEQLQPRDAFIMAMCRASFPPHYAMSIFANTTQSDGDLRCHTRSGSQDLSSQFINSCSGDAGDFRPQIVAVGTPLPSASLPHSVMQAPVMLTNKNLQCMRAILFLAHNNGGILGTSWHIVLQTLQHLVWILGLKPSTGGSLQAMPKPAVEANVGIQTAVMADLPVLSQMLSQLFESSQYLDDVALHHLIDALCKLSHEAMELAYANREPSLFAVAKLLETGLVNMPRIKVLWRPLTNHLLEVCQHRHIRMREWGVEAITYLVKSALQFKHKTPLKENMELQTMLLSPLSELSTVLHADVRQRQLDCVLQILNTAGEILSFGWPAIIEIIGAVNEHHGEPLIRTAFQCLQLVITDFLTVMPWRCLPLCISTAAKFGSQTQELNISLTAIGLMWNISDFFNQNQDKLMSTQLQDVSILPDFPGTVKMPQFDKLWMCLYAKLGELCVDLRPAVRKSAGQTLFSTISAHGSLLNPPTWQALVWQVLFPLLDNVRALSSSASNEKVDASGNILIHHSRNTAQKQWAETQVLTLSGVCRVFNTKRELLQMLGDFERAWSLILEFIQNAALSKNGEVSLAALKSLQEIMYHNTAERTERALKDPQTAQEQDEEIWTIAWNIWLSIGMESTKMSTSTSAKLQQQNSNGAETQEDFYIPSQAFLTALIQIFPAIFQHIQVKFTAADFDKFCTVLTNAVCIPVQTDAVPYIMSTVSDTLLTPLHDGILDCMELIQKEATKPDSHISQLIPAIFRQLLIFSKFACAPPTFQQSVEHKYAKSSGHYANNASVEVVSMNYIPFGEKSISICVKLYQTTATEDSVVQEQILHDIVKALRTPLAMKYKCLSSSTWKLAISSLISVLHTGLKVARAKPQHFASLWDDLADTLDKFLFPASVCTIEDRGLEEIVLDETIDCQVIELLRDEVLPHSHEMPHQFIMQIVVLLNKGSIHSASDTNICYESDWKLREIFAKTCFETLLQFSLLEDHANTNNNRLNANVLTAGAAGAGGKDFAGRLAVTALLHRFQEVLKRFNDDERQSGKCPLPRFRLSEISFVLKAIATLVVSMKKAPASKVNKPAWDQLIGLYPYLVDCTTTTSPEVSRSLREALLQYTDLLQAPRSCSAATSNDNVIQSNGQE
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MSNGQTAEFAPEAAPSSTSFFVEASDGTKFAVTEAACNQSVTIKDLIGTIGSNTALPFNNIDGPTMKLIIEWCEHHKDEEIWAYDYDARIGMSLPAWDLEFLEKMKDEDFEKFLRAANYLSIKKLVTYGCKKIQLMIKDKNPEQLREQFMISTDEEEEALEKKLREESEKREEEENQTTKEPGTSK
The following text describes a protein:
Function:
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGILIPLVSVSAFWAIIGFGGPWIVPKGPNRGIIQLMIVMTAVCCWMFWIMVFLHQLNPLIGPQINVKTIRWISEKWGDSKNLVNA
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKIFLAAEDTGAIKEVVFDEGMDTSVQDGPQPLITSFAALGKLKHIQKLALVTTSKGTKYIAAARKNGTIEVYPYLLTEESTPIFVYSAEGAEKCPWIGLTQYDDNTVVAGLEDGRLFFLDVSKVTIESDKPYDAPTASVKGPLACFALDRELYPGKIAVGGKERDLEVFGWAVKGDEVTVRSEFQARNVKSNEIDMRVPVWISGILFQASDKDGFRVITATRHGQIRVYETWHGKRPKWDFKVTKDPLRTLAPGMDASNVVSSDAHSSTFKFNFADNEKIVLKNKDNNQNKEHNRKSPCVVEKFPGSLGAVLHLVTTDNGLLATVGLDRYLRIFDLETTECTAKMFVGTQVSSLLFVDTERKTAQEKHVEETAEKEDDELWNDLDKVEKKSNKRRVAGNDEGKKKLKSA
The following text describes a protein:
Function:
Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP2 and PHO5.
Miscellaneous:
MISCELLANEOUS: Present with 3420 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MELQNDLESLDNELNDFSEDPFRDDFITDEDAVRSGWRSAWTRMKYWFYKNRLKWTNNPIVIGDAKDSRDGSNFRRGIPLYELDANGQPIDTELVDENELSFGTGFHSKVPFKIIFRTLFGSLVFAIFLILMINIAKPHHSTRVLSHFGSPEFDPYVKYFNGTHEFFPLTIVISLDGFHPSLISKRNTPFLHDLYELKYDGGMNITSTPFMVPSFPTETFPNHWTLVTGQYPIHHGIVSNVFWDPDLNEEFHPGVLDPRIWNNNDTEPIWQTVQSAFDGDIPFKAATHMWPGSDVNYTKYNEEKLQPEHKNPIARERTPFYFDEFNAKEPLSQKLSKIIEYVDMSTLNERPQLILGYVPNVDAFGHKHGYPSESEYYYEDFTETLGEVDTFLKQLVESLQERNLTSFTNLVIVSDHGMSDIVVPSNVIIWEDLLDEKLRKDYVSHAYLEGPMMAISLKDSGNINEVYHNLKTSIDEDKYTVYVNGNFPKEWNFNDGKNHHMASIWIVPEPGYAVMKKEQLKKVAKGDHKDKNEDNVFTIGSHGYDNNAIDMRSVFIGMGPYFPQGYIEPFQNTEIYNLLCDICGVAEKDRNSNDGTGMLMNQLREPQSSEEVEIEDDFDYLVSKFGEFSTYNIIWGGYPEETEQDNVDNDNDDNDDGNTDEIAAMPSSSLTIKLEMTTSIPSATETLLGETSPSSRSSSSSSIQASATASTVGDWLQDIINDAKDLIDDIIDSIDDLVDSDT
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MHSLKKVTFEDVAIDFTQEEWAMMDTSKRKLYRDVMLENISHLVSLGYQISKSYIILQLEQGKELWREGREFLQDQNPDRESALKKKHMISMHPITRKDASPSMTMENSLILEDPFECNDSGEDCTHSSTITQCLLTHSGKKPYVSKQCGKSLRNLFSPKPHKQIHTKGKSNQCNLCEKAYTNCFHLRRHKMTHGERPYACHLCGKAFTQCSHLRRHEKTHTGERPYKCHQCGKAFIQSFNLRRHERTHLGKKCYECDKSGKAFSQSSGFRGNKIIHTGEKPHACLLCGKAFSLSSDLR
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
Subcellular Localization:
Cytoplasm.
Sequence:
MADSTSFDERPAATMSAMLSKDKSKRLSKQNINPLQKCIGDFINTHLSQSLLAQHAVPLEELVSSLPKRYTIYEPMLLLPLNAFTHPPAWAKLYEGLDDNQRQTLYASIASAFSRYGVTHVAMNAPIVLTDTQGHENRMRSPIGLITLHGDFGPATSRDGEDIQPSEDDYKRAFWVRTVQNHGIVQIWAPLHTMFSRGNVTEKARILGHGSTFEGLDEVSLHGKTAGDVAVIDMYAGIGYFVFSYLKRGVQRVWGWEINGWSVEGLRRGCVENGWGCKVIRVGNDGQLSVPVDELVGGLCDTDRVVIFHGDNGFAAGIMRQVRDAMEGRQGWTNIRHVNLGLLPSSSDAWDGACRIIDGDKGGWLHVHENVDVQQIEVKRGEITATVQGLWTESASQIANTEPRAECRHVEKVKTYAPGVMHCVFDLHLSHQEICGNAP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLGMYVPDRFSLKSSKVQDGMGLYTSRRVKKGEKFGPFAGEKRIPNEVDEGIDNRLMWEVRGNKGEVMYVLDATNPRHSNWLRFVHEAPSQEKKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDMEEAEEENTEIVNVVNKEEDENIKESQQPSEKEYITYKEDHRCPHCESSFPSQEILAEHLQALHQKPVEEKEFKCRNCGKKFPVKQALQRHVLQCTENIISGDSSSSYQCSVCNSSFGSSLSLEQHREACKGDARFICKADSCGKRFRSKDTLKKHKENVHTGNSKKKLMCSVCNKKCSSSLNLQEHRKVHEIYECQDCDKKFISANQLRRHMITHSEKRPFTCEVCCKSFKRLDQVTAHKIIHSEDKPYQCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNSERTFKCDHCDATFKRKDTLNVHIQVVHDGHKKYKCDLCDKAFVTPSVLKSHKKTHTGEKEKICPYCGQKFASNGTLRVHIRSHTGERPYQCPYCDKAFSKNDGLKMHIRTHTREKPYQCSECNKAFSQKRGLDEHMRTHTGEKPFQCDVCDLSFSLKKMLIRHKLTHNPNRPMAECQLCHKKFTRNDYLKVHMENVHGETDS
The following text describes a protein:
Function:
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
Subcellular Localization:
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Sequence:
MSDMAMIRIGILIAGLLLVAAIFLFGRPKKSPQGRRVDKDDTQPRERREPVISSGVDADGMPFERSDTGAEQSELELDDQDGAGGNDVGKRPNQDFDKIVSLFVAAKAGQVLRGEDVVVAAEKTGLVFGHMNVFHRLVEGHPERGPIFSMASILKPGSFDMANIREMQTPAIAFFLTLPAPMTALDAWEKMLPTVQRMAELLDGVVLDDSRNALGRQRVAHIRDELRAYDRQHQAPPLTKSPRW
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MPAANPSIRSQGNGEGGHTSYRTAPSGQRASGSSRGITSWKDVHNLDAFLTRIYEYYCGKGYFCMSLVDLTSIASLAFIIFTSTFLLSCVKYELIHEKKRLLDVVDSDCIGSMSWPTSTILLVFILWWVFQVFRFFTSLPRLREMQAFYTTILEISDDKLQNTLWSDVVDRIIQTRDLYGRSNPTAVLRKLDAHDIANRILRKDNYIIAMINKNVLNLSVPLFGKRQIMSKLIEWNLQWCIFELVFDSKGQIRKEYLRESQRSRLIERMQKQFRKMAILNLLLSPFLLIFLVIYSLFKYAEEYQRNSSALSARQYSPFAMWKFREFNELPHLLRTRLFRSTESANTYIRQFPHYPLVIVVKFISFVSGSLGAILLALTLFEEEMQQGFEISPGRSAFFYIGLCGTIMAISRSIVPPETEVYDPEQWMREVAAETHYLPDTWRSHAHTSQVRSEFCELYDYKLVLWIFELLSVLVAPFVLYYSLPGCAGEIVDFFRAFTIKSDRLGYVCSFAVFDFKRHGDVRFGAPALGNQVPEAYDGRLVSNQGKMEMSFLNFKANHPHWEPDVDGEEYLSRLLAHRRDRIIGSGGLRPNHLGSGAASYQGSMMGQSRFAQPMGGTVNGLPSPYRHELMTSTMMESPGLNGDGRYGSGMMESYLRGESMIQTTQLNAGRVGRELLGILDAIHEAHHYMM
The following text describes a protein:
Function:
Transcriptional activator that acts as a positive regulator of grain size. Binds directly to the DNA core sequence 5'-CATTTC-3' found in the promoter of MADS1, and activates MADS1 transcription. Increases grain width via direct up-regulation of MADS1 expression. Promotes active chromatin modification at the MADS1 locus by increasing its level of histone H3K4me3. In GST pull-down assay, binds specifically to histone H3K4me3, but not to H3K4me1 or H3K4me2. May facilitate the recruitment of effectors to mediate gene expression.
Miscellaneous:
MISCELLANEOUS: Plants silencing CWZF7 exhibit defective development of awns in grains.
Subcellular Localization:
Nucleus. Note=Exhibits a speckle-like distribution in the nucleus.
Domain:
The CW-type zinc finger domain is not required for nuclear localization.
Sequence:
MLSVRRRQEDARGVGLRGGAAAGGMEDDAELEEGEACGDETAFVDPDVALSYIDEKIQDVLGHFQKDFEGAVSAENLGSKFGGYGSFLPTYQRSPLPQTRSPPKAANVSSRSPYHQPTESMSQNTLAVAAPSVSKHNGSMVPLSDDSSKKEVHQSTKVERASSTQDSLNGLSKSSDHNRFKVRIKVGSDNGLARNNAAIYSGLGLDISSPSSIEDSPDGCGSLSPEFNNVPIESPRTILQIMTCFSVPGGFLLSPLRDDLVQLTQKVVPTSKKWETNANTENVQERYEGYAAKRVKSDAKKKKAVDTKRSKSRNDVSAVMKNEIDIETPAGQKIVLEALNIPLLSNPRTMEAKDGSQFEEDPMRDTLVENKDARLKERTINSDLMAIKYENVKAEAAECLENSGPGSSGMDFSAVKGEVKFKAEKAEIHVEDRNTTSEKDFQSDRKQERKIKTESKCNATGVNFEGNKVMNERTPVVGRSIGKVSSKETLLNDINEENVSKSESRRSQKEQNMNASSSSDFLEDDRGVLSSGAVKERKNDSQSKSSHPGRKPKAKSHRDVREHLPEGSYGGKDDTLENGSGLGELRPKKIWKNDSERDSDMPGTSKREISSSLKNDRHTPAEEQRMHVPPSVSAPTANAAPMLPAPVVIEEHWVCCDICQKWRLLPYKMNPSLLPKKWKCSMLQWLPGMNRCEVSEDETTNALNALYVSPAPGNGVASVGHSHVASSGLTTSNTLNVNGHVEQSRKRKNTLSDGNVSFDVSQQMQGSVYPLSNQHAPIRSKSAADSIQFPVERDSKSVDHFVEKKRSKSKNHGSSSDGGHLVERSKKHSKVKSKREMDHDEYRTSKKIKKEERRQRQSGIDSNPGYDLASGDVPDEAKALPSKSMALQGSSERSDVPPSKYKSVSKYNSSEKSKRSKDGDVFLPEDKNKEHSYPSDAQKPDLSSKKRIVKEWEESQHNSTPPVSKMSIVNQSSSSKETCKDQNLKETKSKLTKSEEPFAMTDSKSIKVAHSNQTSRNLNNELFEDSTPFAVKSGMSEPPENRSSEQALDLAEPASSDLAYFQTTAVTSSSSKASGSQRRKQNFHVAKTSPIESVSSSPPRISNNDKVSHDKILGKDGSTCANTNNMQSLVKNTEVIVDNVRQARKSHESMLASEPVMNGFSQGNSDKDNELPQLTQGHASNGIISGRSLDDDLQHASGRKDSSLKSSNAARSHNHLHYANKNNLLTDGSSIQHRMAVLDTKGDSMVHENKRSVTSLQDRNGSTHYPPDGNPQSEVSFGKEKSHPKSNKHDMQNSKAQMLPSPLKESKVESHSAPLRSNASKLTAQLKRGNVENGGQHGITKQAISNPADTSSPVRKDNNSTGYALKEARDLKHKANRLKEEGKEQESTRLYFESALKYLHVASTLEPPPSIDGFKQCDAAQNLYSDTAKLCNFVGHAYEKSKKMAAAALAYKCVEVAYLKAAYYKYPTASKDRQMLQAIVQNPPGESPSSSASDIDNLNNNGLSKGPSSKDANSPQVTGNNLLLAARNQPHLTRLLAYTNDVNCAFDATRKSQMAIASAASNQENGIDGLSSVKTVLDFNFQSVNDLLRLVRLSMESISC
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MYGVHGGRSRCSPFWEQLMDCAQQAGRRSQWEKCQHPREDYIECLHHRKLYTRIERIEKEKEKLKKEGKWPPKQEEAKS
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MGESLDRDGEKARWPIPAPPRVKRPPPIKAPEYVSAGDGSPLKVHSTGSILLSKLKETDCFKSFSKPCIFYDVPPGFGVFLSLDKLVLSRENVNTPNARYRNPNRSDKMRLKSLISYKVYDAHGNFLLNALEDGPWLDRLCCEEARGFEVKFTNEEGEASATIMRAQRKYKNCTCFPCFLTGCCRCNSTEMTVVDADGVPVGTSCLRLVFWIFNHEHDPSFIISGPCFNIQKPLCIFYKMHDKFFIYPLTKCGTLGKISREFGTMAYEGYHDKHILLAEFPMDFDIRVKAVLLAAMSMLEIMYFDLMDMRPLAKFISPKTGQKQPKKL
The following text describes a protein:
Function:
Transcription factor that acts synergistically with tal1/scl and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate. Induces globin gene expression together with fgf (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSAIERKSLDPTDEPVDEVLQIPPSLLTCGGCQQSIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAFEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKLNEMM
The following text describes a protein:
Function:
Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport, probably by mediating correct membrane localization of YPT1.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSFYNTSNNANNGGGFYQPSAQFAVPQGSMSFQNTVGSSNTGNDNNLGVAPDPLPVGILHALSTKGYPHEPPLLEEIGINFDHIITKTKMVLIPIRFGSGVPQEILNDSDLAGPLIFFLLFGLFLLMAGKVHFGYIYGVALFGTISLHNLSKLMSNNDTSTQTNLQFFNTASILGYCFLPLCFLSLLGIFHGLNNTTGYVVSVLFVIWSTWTSSGFLNSLLQLQNARLLIAYPLLIFYSVFALMVIFV
The following text describes a protein:
Function:
Involved in both the vernalization and photoperiod pathways by regulating gene expression.
Subcellular Localization:
Nucleus. Note=Probably DNA-associated.
Sequence:
MASFHKGAAGDSMGSSKMSFDQRRQLVLKLSKESEREFKEVLKDWSCNEIRELLRAESKKDIKYTGLTKDEIITRLFNIVSKKNTRDHEVEEIIPSPKRQKRDLVTPLAKAKGKGKMYCQNLACQNKLREEATFCKRCSCCICFKYDDNKDPSLWLTCNSDSQFDGESCGLSCHLNCAFDSEKSGLKEDTPSSDIDGCFNCVSCGKTNSKIECLKKQLIIANEERRVGVFCYRILLAHKLLKGTKKYIIVSEEVEKAVMHLKNEFGVPISCLPSKMSRGLVNRLCCAEKVKKHCSSALKELDGLPLPSTIQGSMKIRIESVLATSVTFDIEAEESFSWGDTNHYRMVYRKVSEKHSSKDLTRELFSTSSHQRFTVMELTPATEYWFKIVSFSGVEELSVDEFIVSTKTLQDEEVAAVLLNMSNCNNANKMEKSGSCSFGFEECVNLIRQLECSGQVKSDFRKKFLTWYCLKATDKEKHVVEIFVDTFKDDKEALAKQLIDTFSDCITRKHPEIGGGSESAGVSLILLQD
The following text describes a protein:
Function:
RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, P-body.
Sequence:
MMSGYNGDGVSSLPTRTQSPLARGAHPGAVLLSPKRTALGTLGGGAGGSSAQLMSPSQHSLSLNDILDQQAHPSRVDSSSAMSLDASIHQQQHTSGVGMLSPLLQPQASSISVKTAFLDSFGSRPSSAIGLQHGQGQGPDGPQSATGMSLNNSNIMVNFTNDVNQLCTWMSMLTSAQQNTVMDNLLSSLNEEVLQHTKLKLESLTNSGYLSPSLRPIASPIPSRVATLETSTQSASSAQLPGSLMLDSILSDSAAAGAGSTNSNNTNMASHSLAVNSMYRQWSPSPQMNSAQPMFDYLNDITRPRSAEPSRLRNGHTSHHQNGSHHIAMNSGNGAPPNSHSSTGHQVSSQAGGRFSNIKPQRPHSPTSLTKSTSSSSNFSEAQSPAAQPTSPGPSTPNAASNVSSSSNMNPKSLCDPKLLKNIPAWLKSLRLHKYSASLNGKSWQELIDLDDAILEDMGVSALGARRKLLKAFAIVKECKERGLVDESAY
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTECLTECKALVTPSTRNGHRVFSYTLESHTSAAFAIMNELRLERQLCDVTLRVRYKDLDEVDFVAHKVVLASSSPVFRAMFTNGLKECGIELVPIEGIHPKVMERLIEFAYTASISVGEKCVIHVMNGAVMYQIDSVVKACCDFLVQQLDPSNAIGIANFAEQIGCTELHQKAREYIYMNFSQVATQEEFFNLSQCQLVTLISRDELNVRCESEVFQACVAWVRYDHENRRPYVQALLQAVRCHSLTPNFLQTQLQSLDWDPQCKDYLAQIFQELTLHKPTKVNPCRTPKVPQLIYTAGGYFRQSLSYLEAYNPCTGAWLRLSDLQVPRSGLAACVISGLFYAVGGRNNAPDGNMDSNALDCYNPMNNCWCPCAPMSVPRNRIGVGVIDGMIYAVGGSHGCIHHNSVERYDPERDQWQLVAPMLTRRIGVGVTVMNRLLYAVGGFDGANRLSSCECYNPDRDEWRTMASMNTVRSGAGVCALDTHIYVLGGYDGTNQLNTVERYDVETDAWSFVASMRHRRSALGVTALCGRIFVLGGYDGSTFLDSVECYDPKEDTWMEVTHMTSGRSGVGVAVTMEPCPKGLSKSQKCENDPSADPSAGCDRPHCQFSNGPFGKDASF
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSTSTNDPADLLTVILDLNPLAWADLESGESQEETTSLVSVIESFLIFANSHLALRHENAIAVYGASLGSSELLYSSLQAKPITTKSSQPSGSRDANTYQSFRILNDSIASGVKQLATLTQSSSMTGKQPGIVKALAKALCHINRLARENENKKESLKARILILSVSSDAPGQYIPMMNCIFSAQKSTIPIDVCKISKENAVFLQQAAHLTEGIYYQIEKPKAILQYLTMIFLPGLAARKFLNLPKHQEVDFRAACFCHREIIDVGYVCSVCLSIFCTPTPVCSTCRTKFPMSTLKRFLMEKPKTRTKSANGSIVSSPLRSS
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSRNNFPAGSEIRIGSVTWSHPKAAARFSSEFSFLYIEERTTIRFGASRLIHQMMKSVRAYLNSPMGPKTTHFWGPMANWGFVISGMMDTKKTPDAISGNMTAEKMDEEPKLGGRLGRYKGQNVVYIFDVVYEICMDGEASKLYAASLPCC
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MEADPDYSHNQINPTGTTEPKTTRNKLIYLSFSNRVKLHKLPHLTDNYATTTTSSDDDLSSSSSGGFQRSSSSSHTNPLEDNPFYHLSHSHGFYITPSDVVLRHIVYDYQHQPSSASATSLDDDDDDDDAVAAYHRAGPRRQIFFQVSSTKAAIVTCGGLCPGLNTVVRELVLGLWDLYSVRQIFGIKAGYRGFYSKELEPLQLNPKLVHNWHKIGGTILQTSRGGFHLQNIVDAIQHRGYNQLYIVGGDGTMHGAVEIFHEIRRRKLNIAVTGIPKTVDNDVGIIDRSFGFQTAVEMAQQAISAAHVEAESAVNGIGLVKLMGRSTGHIALHATLSSRDVDCCIIPEIPFYLEGKGGLFEFLEKRLRENGHAVLVVAEGAGQDYMRRRMGMDRINEDDAQNQKQDISIRAAGGRDESGNPVFLDVGQWLKSELNKWWRREHPNELFTVKYIDPTYMIRAVPANATDNLYCTLVAHSAIHGVMAGYTGFVSGPVNGNYAYIPLEEVAKAKNEVDTRDHKWAWVRSVTNQPDFQTKS