lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Membrane raft.
Sequence:
MGAVLRSLLACSFCSLMRAAPLLLYANRRDLRLVDAANGKENATVIVGGLEDAAAVDFVFVKGLIYWSDVSEEAIKRTEFNKSGSVQNVVISGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPARGFMYWTDWGEVPKIERAGMDGSSRSIIVNTDIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGSHRQAVVKGSLPHPFALTLFGDTLYWTDWNTHSILACSKYSGEDLREIHSNIFSPMDIHAFSQKRQPNATNPCGINNGGCSHLCLMSPTKPSYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLPLEDIRHAIAIDFDPLEGYIYWTDDEVRAIRRSFVDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRIVLVNTSLGWPNGLALDYAESKIYWGDAKTDKIEVMNADGTGRRVLVEDKLPHIFGFTLLGDYVYWTDWQRRSIERVHKRTAEREIIIDQLPDLMGLKATNVHQIIGTNPCAEDNGGCSHLCLYRPQGLRCACPIGLELINDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRASMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLDREIIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNSDNRTCSAPTTFLLFSQKNAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNIIRKAQEDGSQSLTVVISPVPNQNLDMQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRPMGVVLKGDQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALAIDSQLGKLFWADSDLRRIESSDLSGANRVVLEDSNILQPVGLTVFENWLYWIDRQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNVQEYRQHPCSQDNGGCSHICIVKGDGTTRCSCPVHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEKNCPVCSDTQFQCESGQCIDSALRCNGEANCQDNSDEKNCEVLCLTSQFRCASGQCIGKSKKCDHNLDCSDSSDEQGCYTTEEPAPQPNNTIGSIIGVILTLFVVGAMYFICQRVLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSVISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPPILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRVTATMAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
The following text describes a protein:
Function:
Component of a transport pathway that contributes to membrane integrity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MCEHHHAAKHILCSQCDMLVALPRLEHGQKAACPRCGTTLTVAWDAPRQRPTAYALAALFMLLLSNLFPFVNMNVAGVTSEITLLEIPGVLFSEDYASLGTFFLLFVQLVPAFCLITILLLVNRAELPVRLKEQLARVLFQLKTWGMAEIFLAGVLVSFVKLMAYGSIGVGSSFLPWCLFCVLQLRAFQCVDRRWLWDDIAPMPELRQPLKPGVTGIRQGLRSCSCCTAILPADEPVCPRCSTKGYVRRRNSLQWTLALLVTSIMLYLPANILPIMVTDLLGSKMPSTILAGVILLWSEGSYPVAAVIFLASIMVPTLKMIAIAWLCWDAKGHGKRDSERMHLIYEVVEFVGRWSMIDVFVIAVLSALVRMGGLMSIYPAMGALMFALVVIMTMFSAMTFDPRLSWDRQPESEHEES
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MERMDRPPRPRPHERQMEGAQTPPVMEFKAHPIPLARIRRIMRADADVNMISAETPVLFARACEMFIEDLTARAWKKAQESGRRTVNKSDIVQIVSGTKILDFLDDILPPEWASGSKPEQDRMEETPPKPFPDAVSDFVSLSCAQNSQNYFTMCHLI
The following text describes a protein:
Function:
Major thyroid hormone transport protein in serum.
Subcellular Localization:
Secreted.
Sequence:
MEQNGVFLWICGFAIVVCGNQETLQQPPISAKLPSLININNDFAFHLYKRLIESPDYQSKNIFFSPFTVSMALSKLTLGAGGDTKQQLLSGIGYNSAIFSTEEMHQLFHSLLEDIGNRTGVDIDIGTALYASDRFKPHSKFLEDMKEFYHTDGFTVDFRVKETVDQINKYVEEKTHGKINQAVDDLEKDTLMFLLTYIYFKGKWDKPFNPEKTCESTFHIDDKTTVPVQMMHQYEYLKVYYDAELSIKVLCLDYNDSFSMFLAVPDVHMGRKTIEDLEMTISRQHIEKWKRSAFERKVDIYVPKLSLKTSYFLNDILKGMGMADMFSDKADFTGVSEEKIFISKVVHKATLDIDEKGTTAAAVTTVQFRQLSYSPLSTLSFDRPFMIFITDQTNDNILFFGKVVNPNEKPTS
The following text describes a protein:
Function:
Microtubule binding protein that regulates the stability of dynamic microtubules. Required for mitotic spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Colocalizes with cytoplasmic microtubules and associates with the mitotic spindle throughout mitosis.
Sequence:
MADKDAQDFLKFLKSNASTDEKTRCLDTLRSFFNKNNIPNADLGLFVECFRLALTTVNPLLLRSSVACFETFLRRLRAQYPTWLKFRVPMLKNLVIDHIASRDLQKRVLNILIDLWHFNPSEIEKSLIHLSTTSKSAETRIQCFKWFVLAHNAHLSFDVKSLRPALYINLENANPSVREEAKEVLLLIYKNLSTSAKMQFITDVETTSGLRREILQSLVEELSLISSSSEVIIVQNSASSFQPAPFMTAVATLYPGVELENVKPLLANFSKQLEQDSASMLPAFEGRETEQNWSVRQDSVLRLRQYLRGNACIDYLPELLSVLKTLLPGILLALLSLRTTLSSSAIQLIKEMAIILKSNIDPFLELILPNLLKVCSVTKKLASQAANVTFAAILVNCGVLSRNLSFISLAAHDTNAQLRVFSSNWIFMLISLSPELKNLASLQTNLKAFEKLICRGLADSNSQVREVYRKSFWKLSEYFPSVQEELTNTLEPSVLKQLHLANPNRQAASFNFSGPKRAPIRPLSNLRSFSKSQKEETSSNSSNSSGTRRLGLPQRATPASRERVLPYTRSQAFHSTSLPPSLPSGHSPSIAIPSKRSVSATIKDESKTFELLKNIQRKYELILSGSSVDLPSAEFLSSNLTDALYSGSSICYSLIFSHSLLDLTFQYVDIASLLSQFLLCVYDPSNVGHSFALASFPYVKSHYDAHKYFPIVFDVLMNISNMAPHVKVFPFNTNQKRLIIHGCLLWLKEISDTKLNQLENKPFFVTDKLRYYSSKILAMTAKTKLTSKNWIPLSGLLFSLRAHDTFMFDGLLDRLNEESRTKLVSSWSKQDAFDYSKSSTHQEHLSKNLPTLNTSSSSNSSQTDLLVPHGKGETKETEMQSPIESKEGLLSKDTHIESPQGTSLEKENEEEGKNPVESNCSEESLDDHNIDQTLVNKKETLAQDSESLLQKNNALNEKGFENQFGLSSSAAKVLNKDTLDHVSGPISNSVSSSFKDFTRTPFKEINGERETGFELTSYVNALSKKDDINVQKTENVDESVGLNAMFMDNVNQDSLNSVDQSSGKDKLLLTSSTPNKPTTFFMPANEEILGSPAKDYDIHDQSYSVHELHSENMRENVGQSSLIYNNRDYMNTPMNDFSLSFSEIKGGILESPVESPMTGTISPIDADESVLHDIPAYESLNKSESNKYQEQAYSTPLHHTLNVLPKNKWILSRMHKMENGSPINVDKNLDDAVAALEAAVKELNDGSVNTKTLKFCIKVCKETPSMLYHSHGLLPAILHYIESNNSAMHISDCLILLHEFLVQGYQGVDMHTYHNIICILIEKAEKCKDEPVILAGIEDNITLIAEIADLQGLYEFTQQRLQSLNTETGEKSAPLLLMLLSAILMRLKDLEFLETKDLLRHVVLKYIDHTNPEIRKATFNVCLAVNTIVNNVDETFSILGGLNEGQRLLFMHYLKMKSDEKN
The following text describes a protein:
Function:
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
The following text describes a protein:
Function:
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MASWNPAFMPESAADLPAPLPTDNTVADSTDHANGVAQDGSDFWGIDGGEEDVPAQNGASDSWFPDYGTGSHTTLPATDAQATSQITSETDTDTPDTATEQTETAHVTTEDAEAVEPAPTQTDEAPEPIVENAQATEAVPGDAATVDLVPEHVEPTDATTTEKADTDEPSDVASKHTSTMSFTRTIPHEPSWSDDGDPEWNLARADTDPFKFLPSSDRTNSFPPVPPLEQHEQQQEEQQENQQVQQVQQQQQQPQTDPHLEQSAIVQPQVANFLGDDDEVEVQGDDGFFSQLSEAQNDGFDQFGAQDANNSQQYMVGDLGAKATEALDARFEEGVPLIAHDGNSTAEREDTKDLFGGEDANDEDDFFSQVQQGSVNQADFEAQPLERKSTMQVLGAMDMGSVQPSFPPVEEQPEEEAVATVETQTHDHPEITSTDLNTGEGHEEQKPAGEDVEAKWKELFADDEEDTLSLLDDSTEASNEIKEKEIDPAAFFGSDDEGFLDDSEEFPTMEETTQPRAPSVAGSNTTTTPTTRYMPQTQTPSLTGAPNPYAPTAPPLTSAPSNPYFPAAPSAVAQTPSVTPFGAPVSAPPPSGRFGYGAVPPPQIERKAQSFVDKKGGYQSPYDLPMEVVKVKKRPSTATLNKPVTAPAAPPPSKSATHLPPPPPPTSVPHSSQPGVKPPPPRGEAKPKEKFFEELPVVTKARPASRNTLGTASPAQSSPYGPPPPAGPPSIASQPPVPGMPSAMGSVPNSSFTQHAEVPNLVAPPRVNPYASIQPSTTSLAPAVPAPASSRYSPAPSSGSQLSTPVPPAAASRYSPAPPASRPTSSGYTPTTSVPPVLPPVLPHQPRTSSPLAHFESRPLVSSHAESGLAEKRSSSSLYDLRLQRVPSLPPTQEVEEEGPMQGMVSPNQVPASHQTSPTASRHGAMPHRSRRTPPPQSLTVQPVTSPQRAAYSYQPAASAPSHEFAPPPRSQTQSPGALYGNRNVKPIEPIPRPSSVTDATSPRAALYSPITMQPSSTFPPISTITSRPRGNTQNFNLVPPTDGREHDPLQRWRGVPLISWGVGGALVTMFPKNVPRYGMGQTAPMVIRSPGEVKVKSMKDIEPMEERLAKFPGPLKGKSKKKETIAWLTNGIEMLERTVPHNLSHQLNPSHDDKRTTERLLLWKILRVFVEHDGVLEGNPTVNQAVREILYPEASTIGGQPEFANALNPSGMGNSATTSLQADSVDSSAVEQIRNHLISGDNEKAVWAAVDKRLWGHAFLLANALNPDLYKRVAQEFVKNEVNSTGHNNESLAALYDVLSGNHEESVDELVPAHARAGLQLVAKNSSSGPSKDAMGGLDKWRETLSLILSNRTADDARAINFLGNLLSGYGRAEAAHICFLFARSQTIFGGLDNPNSNFVLVGSDHRRQADHFAKEIEPLLLSEVYEYGQSLAGGTVPVSNPHLAAYKLQHAYALAEYGFRDKALQYCEAITAAITAQTKRSPYYHPILEAYVDDLMKRLRQAPKEESNSWIPKPSMNKVSDSMWNRFNKFVAGDDNEDGSKGSPDAAGESGPFARIAGGTPTISRSPSVNNLETFGATIPSYGMPSAPVTNGPNMFSPPPPTRTASRYAPGAPQPSTPNYNPYETNSPYAPRSSMERASGEYSRSSVELPRQSLDSQRGYSHSSYAPNRTSSPAQPYTPYGTTPQESSYSLHNMQPQQSLTSPAATTSGYQPFTPQNNVSANDEPSNEPPSAPSTGYQPPSYGYEPPSFTPYEAPATNDEEEGASKENGDSNQGGEGVNTFEPPSFQPYSYEPPSYEPDTPPSKDDDQSEEEKPKPKKKGPMYDDDDDDFPAAPKPAGKSKAEIDRENEEMVRRIAEEEAKRAAEAKAAKKGWGFTSWFAKKEAAAADANAAGSSPGKPIRAKLGEANSFYYDPEQKRWINKNASPEDQAAKKSTPPPPKGGIPRSSASSPAPPMGMGVGGGSAPNTPGRASAPPTGPPRPAALMPSASESNVGSGPPSAVGPLSPSGSNGPPSAGLLSPGMGPAAMQRPASTSTSGPPAGTSKPLSATSSIDDLLGAAVPRKRGEAKKPRKAARYVDVMQK
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MYMAIVICTVCYVGKAEWFSSMEQITDLLRHENTMLPALQRFVDAKRKQLAQLQELVYLTIYRKASVSINKEEYISHPINQYHLIKRFANDWTQIAALLQTFNKTSKFINIISAIFKKAKTLFPKDEDMKGGTEGILRVQITYNLNASDLVEGNIAGKYSFLNLSTDDCYRIGKTALRGGLFGRCVEWIELALQRFEEGKSTFTKRNATEYLDICEFAQTNYKSTVLLRLVKMKPRNRIRFTRTIKWKLLFKRLTFSRHARVQTQEVVDDETFFKLCRGEQTLTKKKQHKKLRCYLSTNMGNPKLLIRPVKVEELSKSPDIVQFHDVLSDTVINEIKKLAKPQLFRAIHAGSDDTDLQKAPYRITKLAWLLDDDGPEVAKITERISDITGLTLNTSEEIQVANYGVGGEYPPHFDIPTTDEERDDLKSQDGERIATFLIYLSDVEVGGRTAFVNAGVSAKPIKGSAVFWYNVFPSGEPDLRTYHGACPVAFGNKWAGNKWIREAGEMFRRKCELDRYADSKILNVRLVYRNRA
The following text describes a protein:
Function:
Transcription factor required for ecdysteroid production in the prothoracic gland by activating transcription of the ecdysteroid biosynthesis gene spok. Binds to the 5'-AGCTTTATTATTTAG-3' DNA sequence in the spok enhancer region.
Miscellaneous:
MISCELLANEOUS: The name 'ouija board' derives from the instrument used for calling ghosts and is based on the fact that mutants cannot induce expression of the ecdysteroid biosynthesis protein spookier.
Subcellular Localization:
Nucleus.
Sequence:
MLNIVCRVCGRQKICEKSLNLFDLVNRKYLKHLHMISGLRLVDLDDVPGFMCLCCQAELRSALAFRKLCIKTQTKWLTIEDDSSSGDEDTNDNSELESEKCAFSDFGKKKEGELVEETFQVLIEEEPMDKTLNRDAKAQLREDGIDEKCVPSQKIIKVSTKLDDQIYICELCGTHATSKPTFQRHMRKHRGERPFGCKDCDARFLSAGELRAHHRVHTGEQPFACRFCEKRYVSYMGRLIHERTHTNDRPYVCEECGKKFTTAYVLKNHMVIHTGERNFRCDICDRSFQRKAHLVTHTRSMMHLQNVKKQKS
The following text describes a protein:
Function:
Has an integral role during the infection of macrophages in the mammalian host.
Subcellular Localization:
Membrane.
Sequence:
MTVIMFPRYIIPFLLGLILCGDVTEGNIPPHRCDFGKLMKNMSMRDLPVVGEPPVPKGDLVHAIVTSSTAGWQPIRFKVFKSDIEDRSKYCGSVGETRSNFRGTNYQCNTDSLLTKEKKSLLSVVIPDALKMHTDRLMVQPVQGPIKVPKLQSFCNNFNIPQDHYTTGVSGADMVLYGAAGPMGSPAAWAGPCSRLKGKRPVVGVFNIGPEVLTSHDSSMRVTAHEIAHALGFGFDIMEELKLVEKRNEIRGKNGVWVVKSQTVVKKARLFYGCDTLTGMELEDEGGEGTVKSHWERRIAMEEMMAGLKSSDGGRYSVLTMALFEDMGFYKAKWGTEEDMHFGKGRGCDFLEKRCVEDGKSNFPDVFCTSETKQGENICTSDRTGLGSCAISTYKSSLPTHYQYFSQSNRGGPGELLDYCPYIRVFSNTGCTNGDPKTMWGSRIGPNSRCVKATGLKLKNVIVAMADICVEVNCKPDILQVRFVGDDQWHNCPEGRNVTSNVTFSSGSIQCPKKSELCASKVVKQTTSAQKGQGKGASSWSAYSCYLMWNMLLFVSCFSLL
The following text describes a protein:
Function:
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MALPNQQTVDYPSFKLVLVGDGGTGKTTFVKRHLTGEFEKKYEPTIGVEVHPLDFFTNCGKIRFYCWDTAGQEKFGGLRDGYYIHGQCAIIMFDVTARLTYKNVPTWHRDLCRVCESIPIVLCGNKVDVKNRQVKAKQVTFHRKKNLQYYEISAKSNYNFEKPFLYLARKLAGDPNLHFVESPALAPPEVQIDLAAQQQHEAELAAAAAQPLPDDDDDVFD
The following text describes a protein:
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein.
Sequence:
MHQISGINAASPEKNNSKLADVSLQQFLANVDEIRHVLTTLSADRHAIYMEQVESLAAGCSDTAKCRKLNDHVDKFIAQARGIRRRLADASEELVQYPESRVGSGRARHEQIQMLIVSLEGIMSQFADDQASYKAEAAKKIAAYLRKQNIEVTDSEIDGAIENGSLFQLTRNINLGVAQKKALFDDMKNRATDIMILEKQIREVEELFVDMQLLVQSQGETVDRIETSVIRAEEYAEQAQQNVRQAVVLRRKNRKWKIVTCIALIVLLLVVVYLLSHFLGAIIPGWK
The following text describes a protein:
Function:
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. The Tol-Pal system is also required for polar localization of chemoreceptors clusters. The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity. Is involved in the uptake of some colicins A.
Subcellular Localization:
Periplasm. Note=Partially associated with the outer membrane through a specific interaction with Pal. Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity.
Domain:
Effector proteins that bind to TolB can both negatively (Pal) and positively (colicin E9) regulate association of the distal N-terminal TolA box with TolA by influencing the conformational equilibrium experienced by these residues.
Sequence:
MKQALRVAFGFLILWASVLHAEVRIVIDSGVDSGRPIGVVPFQWAGPGAAPEDIGGIVAADLRNSGKFNPLDRARLPQQPGSAQEVQPAAWSALGIDAVVVGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYAGHTASDEVFEKLTGIKGAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKFPAWSPYL
The following text describes a protein:
Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Sequence:
MASDNYADGLPAALAAAVTSAYAALPKTGKPQPNEHTVLAGFALVHDPDDGPESPGSYSEAPRPVVVVALGTGTKCLGGSKRSPAGDVVNDSHAEVIARRALLSWIYDEAAQALRSHQKLSGAVQEPAPAGGAAPAGEAAGANGAAAAAAVPGPASAASDSGPAAKKQQNPSRPQLPPSTPPPVSVFEVVEAEERHQVSAAAGPVAGGCSGSATTLAGDSEPTGEQHHPGHSRHDRLGLQLGLRLRLRPGLRLCMYMSQPPCGDASILAGATAGCSGGGAALQPAAAAAAAVAAAAACQGETHGSDAAAAAEAGGPGEAAAVAPAALVAAGCCGHTNGSSGEGMAAAAVAAAASGTPAAARAAEAGTDAGAGAVRFRTGAKAIKLMAPDAASDAAAGTTPGGLVPCGATGHTTVPPHAAAAAEAAAAAAALPPVAVVVPQAGDVDVGAQDSGAGLGAVRRKPGRGDATLSLSCSDKIARWCCLGLQGSLLSGVLSAPLPLHLLAVGATPAMTAAGQDAALAAVAAASRRAFDTRLRSDPGVAAALGSHTSTGRGGSGSGSSSSGSSSSSSQCRLQPPLHIVGLPPPDAALGLSPDAARKVPSGVCINWHPAAGACMRQLGLGLGLPPAPSPSPSPSPSPSPSPSPSPSPSPSSLQPPQPPQPPAQQDQAHTQKRPQGQRRPWAPAAPLRGGGGGAPPPAEVTLAADGRKAGAAKRGAAWASDKTRSRLCRAALAARLAELLDFMAAAAGGASDGRRWRNWTYARAKLELGGGNTGAAADAGAAAAAGAAGAGAAAASAQEAAAVVPSSDAGCGGVGGGNGSRGGACAGAGAGSGTGSGTGASAGSGSGSGGYCVVWARLRMTPGSMFRLWLPKPASHQEFPLLPTPTPAAAAVAAVVTPTAAAEGPAAEAVPERRTATGGRGGGRSGAGA
The following text describes a protein:
Function:
Involved in RNA-mediated gene silencing (RNAi) of mobile elements and repeats including retroposons SLACS (Spliced Leader Associated Conserved Sequence), TATE (Telomere-Associated Transposable Element) and TAS-like sequences (Telomere Associated Sequence), and a family of 74-nucleotide long tandem repeats, CIR74. Predominantly binds to siRNAs derived from SLACS and TATE transposable elements and to a lesser extent to siRNAs from TAS-like and CIR74 elements.
Subcellular Localization:
Cytoplasm.
Sequence:
MLALNAGSQYPGRGRGRGRGDGGNRVHKHDGINRYHGGFRGGRGGGGGGFRDGDMRECRERESWAVSAAQANARTLARVPVPVETNCFPIDLSEGRFHNYIVSFEFLENATDMAGDMWKISLQNELLRTIRKNRTAEKRTRTSAEVEDLCVCTGQAILAPAKLSVEDGFSIECTRKEKVSRNNTEERHYRVRIRYDGEVSLKLPEHAQWVNKIIAFGLADTYSEHIGSDYVDMKSTVERGGDLVTMDAISLNALRIVKQSGSTTAMMDVLQLDVSTKASTKTKCSDEMRRLRQQNPQGFRRAVNEALVGISVTTVFGEPTFLKVKAIDFNILASSPTMFKTNPEETFVEYFKRKYDAIIDPTLPMLYCIFADRTKMSRRMPYPADSLLLNKLNEAQLSKLPILCSIYPNERMKRIKAALERVLASPLMITVLQQYGVRIQPQFVKVSGRVLPAPTIYVPSGPNMFNRINTAEYTGQAGFALGLKDLQHPSQPCEFKTLLMDEYFMHGNITHWLQKYNVALPSPRKTSFDSAAQRITEGPGTFAMVKLRTKEAGAYNNFKERFARSSIVSQMAVVDLTRNVPQMITQQVAAKIGQLCFVADVDEAGKSFACRPLLIVGAVVGTAMNTMLEKYKSINVRLYTITFVAFLANGKSWKPYCMHHQVKGEEHVLYEDSDAASSHMSSTTLTVRRQNANEVLNNRFPDFLKEVTAHFKLNGKGSKGTMVLYRGAMTDAEVGFTANMDLVMEQVLPNWDTATVVVHPRSHFRMAWDPTTVFPHETASAYAGLSNVPRGFSTTDCRIILADSDPYTPVDSFYLSAANCTLGHAANTYYLVQKRAASISLMDLQKLTYNMCYMYPNKPDALPLPLPIKCAYEYARKYGSLKSVKELPTRMRPTMHYL
The following text describes a protein:
Function:
Suppresses neurite outgrowth.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MMKPSIAEMLHRGRMLWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRRLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIKKTELCPLLSDSEVEASLGIPHLSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENLTHRDVRTIELEVLCPEMLHIAQPGPSPPQPGDYHPNGGPTSASPYEFSPPGGPVPLSVLILSLLVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDSGGNSGGSGGGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAASAAQDTGATDRGGPGTQPTGMAEVLLGSEQFAETPKENHSNYRTLLEKEKEWALAVSNSQLNTIVTVNHHHPHPHHSAVGGVSGVGGGTGGDLAGFRHHEKNGGVVLFPPGGGCGGGSLLLDRERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQTPKSDYLDLRAKLQTKPDYLEVLEKTAYRF
The following text describes a protein:
Function:
Negatively regulates the expression of sulfate ester dioxygenase Rv3406 and its own expression. Binds specifically to the inverted repeat sequence of the intergenic region between Rv3405c and Rv3406.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Domain:
Contains an N-terminal DNA-binding domain and a C-terminal ligand binding pocket.
Sequence:
MTTRPATDRRKMPTGREEVAAAILQAATDLFAERGPAATSIRDIAARSKVNHGLVFRHFGTKDQLVGAVLDHLGTKLTRLLHSEAPADIIERALDRHGRVLARALLDGYPVGQLQQRFPNVAELLDAVRPRYDSDLGARLAVAHALALQFGWRLFAPMLRSATGIDELTGDELRLSVNDAVARILEPH
The following text describes a protein:
Function:
Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
Domain:
Contains a large catalytic C-terminal domain that binds S-adenosyl-L-methionine and a smaller N-terminal domain that may play a role in tRNA recognition. Domains are connected by a linker region.
Sequence:
MFAYKLLVDERGKRYLLKKNVEKFGTDLGIVDMKDIEEGVELKSHKGHTFYLVEPTMFDILKRMKRTVTTLLPKDIGFIIARAGIREGETVVEAGTGSGALTMYLSNAVGKTGKVITYDIRPEFAKVARKNLLRVGAIKKGQKIIGLDEEFDDEDEIEIEDGLFNVIQKIGDVREKIDEKDVDVIVLDLPDPWNVVENAKKALNKKRGRIVTYLPYIEQVKKTVEKLKEEGFWDIHTYEIIEREIEISEKGVRPSTRMIGHTGYITVARVPPEPLDREEEKE
The following text describes a protein:
Function:
Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MFNNHSCMLESESSITDEQYRITLFVFNKSQTENESKPNQLLTKFAKRSCHATRQWLTEKLFPLVCKWSNDENTKLPKDSKKFPTSLSLIDKEKYSILYQELKRKYGLELAKVWPEVTDPQKYVYEDVAIATYLLVLWEQERELLGTSKLQSFVDIGCGNGLLVHILNSEKHPGKGIDIRKRKVWEVLSKANLEEDVVTPEDLSTLQGYDWLLGNHSDELTPWIPVMASRCSYNTRYWVLPCCFFDFNCKFERSQSTNGQYRDYLNFVNSVGSECGFQVMEDVMRIPSTKRVCYVGMKKNYPKNEHSIKLQSIERYVTSRCDETKYENLNFVPRPKVEKIQNCTKMKRTVQQQIVETIVKKLLSVVNMKENIETGKSWNMGGSLPLHEAAALLDEKTRNEMKNECGGLQTLMRNYHQIFQIRNGNVQLRDWSLTQTRRKRKRKHLADSAVKTKQCWFHISHPDGCPLSNAKCNFLHGNQ
The following text describes a protein:
Function:
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.
Sequence:
MAAERSLWVVGLCPGSRLGRVVRVLLLLLWFAARGGALYFHIGETEKKCFIEEIPDETMVIGNYRTQLYDKQREEYQPATPGLGMFVEVKDPEDKVILARQYGSEGRFTFTSHTPGEHQICLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDKLSELQLRVRQLVEQVEQIQKEQNYQRWREERFRQTSESTNQRVLWWSILQTLILVAIGVWQMRHLKSFFEAKKLV
The following text describes a protein:
Function:
Base excision repair (BER) glycosylase that initiates repair of A:oxoG to C:G by removing the inappropriately paired adenine base from the DNA backbone, generating an abasic site product. 8-oxoguanine (oxoG) is a genotoxic DNA lesion resulting from oxidation of guanine; this residue is misread by replicative DNA polymerases, that insert adenine instead of cytosine opposite the oxidized damaged base. Shows a powerful dicrimination of A versus C, since it does not cleave cytosine in oxoG:C pairs. May also be able to remove adenine from A:G mispairs, although this activity may not be physiologically relevant.
Sequence:
MTRETERFPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRVETVIPYFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVTDDIAKPSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLCPVQAYCQAFAEGVAEELPVKMKKTAVKQVPLAVAVLADDEGRVLIRKRDSTGLLANLWEFPSCETDGADGKEKLEQMVGEQYGLQVELTEPIVSFEHAFSHLVWQLTVFPGRLVHGGPVEEPYRLAPEDELKAYAFPVSHQRVWREYKEWASGVRRPD
The following text describes a protein:
Function:
Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPDINESMLNQFRPVIRRFIDPIADRIALPADYITLTGFLVACAASAGYASGSLITGAALLAASGFIDVLDGAVARRRFRPTAFGGFLDSTLDRLSDGIIIIGITAGGFTGLLTGLLALHSGLMVSYVRARAESLGIECAVGIAERAERIIIILAGSLAGYLIHPWFMDAAIIVLAALGYFTMIQRMIYVWQRLK