lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect.
Subcellular Localization:
Cell membrane; Lipid-anchor. Cytoplasm, cytosol.
Sequence:
MYGICCCCGALRPRYKRLVDNIFPEDSEDGLVKANMEKLTFYALSAPEKLDRIGSYLSERLSRDVARHRYGYVCIAMEALDQLLMACHCQSINLFVESFLKMVAKLLESEKPNLQILGTNSFVKFANIEEDTPSYHRSYDFFVSRFSEMCHSSHDDGEIRTKIRMAGIKGLQGVVRKTVNDELQANIWETQHMDKIVPSLLYNLQQVEETESRSPSPLQTSEKEKEIPAELAERCLRELLGRAAYGNIKNAIKPVLMHLDNHSLWEPKLFAIRCFKIIMYSIQPQHSHLVIQQLLGHLDANSKSAATVRAGIVEVLSEAAVIAASGSVGPTVLEVFNTLLRQLRLSIDYELTGTYDSTVNIGTKIIKEHEERMFQEAVIKTIGSFASTLPIYQRSEVMLFIMGKVPLPSMHHAMDFGKAGENRNRLTQIMLLKSLLQVSMGFQCNNMLTALPSSFLDPLLSSALMEDAEIRLFVLEILICLIDRHGNRHKISSISTEPDISVLKLKVDKCSRQDTLFMKKHAQHLYRHIYLSCNEPTNVQTHYEALYFLLVIISIELATEDVVVDLIRLVLAVQEMALNNEDNLPAYCRCAIQALCAAYLSLISNLTTVPAFCQHVHEVIEMRQKEAPYLLPEDIFTEKPQWSSSMDRVETQLLFLQSKISEVLGGSGYNTDRLSTPYVPQLTDEDRLSKRKSIGETISLQVEVESRNSPEKEEKAPAEEITFETLKKAIVDSVAVEEQERERRRQVVEKFQKAPFEEIAAHCGARATLLQSKLNQIFELTIRPPPSPSGTITAAYGQSQNHSIPVYEMKFPDLCVY
The following text describes a protein:
Function:
Ferric-siderophore reductase involved in iron removal from the siderophores after their transport into the cell (Probable). Acts as a major ferric-aerobactin reductase catalyzing the reduction of Fe(3+)-aerobactin, a citrate-hydroxamate siderophore produced by other bacteria. Catalyzes reduction of Fe(3+)-vulnibactin, a catecholate siderophore synthesized by V.vulnificus, in the absence of VuuB. Catalyzes reduction of ferrioxamine B and Fe(3+)-vibriobactin in vitro. No activity with Fe(3+)-enterobactin. Catalyzes reduction of ferric chelating compound Fe(3+)-nitrilotriacetic acid (NTA) in the presence of NADH, NADPH or reduced glutathione (GSH) as its electron donor in vitro. Also catalyzes reduction of ferric chelating compounds Fe(3+)-citrate and Fe(3+)-EDTA as well as non-complexed FeCl3 in the presence of GSH as its electron donor in vitro. Highest activity with Fe(3+)-NTA as electron acceptor and GSH as donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGHSFFEHLFEHSQHVTPYLHGAIKPRPERCAEHGFIHIEHASSDHIRALYESLKLAHPEAGAAYWLTRTWTLLCWQPLYVAFIAIYSCQGLPKLSSMGQHVQPRFVSGYQFDDDEYRQGSEQELIAHAGKELCALFDYFRQEMSLWTRIRPGFTQHLFADGVFGCLVKLSQFYPTLSGDYFLEQARLWLAACQLPEKLIQSLRYDETSRQLSLVRTSCCLVYKCQGRELCRDCPRHPDNKRE
The following text describes a protein:
Function:
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Sequence:
MAALATLPPLPPQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSRLMDQLEALKKQLGDNEAITQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNVDVEEYEDAGATSLPTQPLQPSSSTYDPSNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGVTSNTIQPTPQTIPAIDPALFSTVSQGDIRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE
The following text describes a protein:
Function:
Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin. Acts upstream of GIS, GIS2, ZFP8, ZFP5 and the trichome initiation regulators GL1 and GL3. Acts as a negative regulator of abscisic acid (ABA) signaling during germination and early seedling development.
Miscellaneous:
MISCELLANEOUS: Seeds over-expressing ZFP6 are insensitive to inhibition of germination by abscisic acid (ABA). Plants over-expressing ZFP6 show formation of ectopic trichomes on carpels and other inflorescence organs (Probable).
Subcellular Localization:
Nucleus.
Sequence:
MATETSSLKLFGINLLETTSVQNQSSEPRPGSGSGSESRKYECQYCCREFANSQALGGHQNAHKKERQLLKRAQMLATRGLPRHHNFHPHTNPLLSAFAPLPHLLSQPHPPPHMMLSPSSSSSKWLYGEHMSSQNAVGYFHGGRGLYGGGMESMAGEVKTHGGSLPEMRRFAGDSDRSSGIKLENGIGLDLHLSLGP
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MFIILSICLISLGPPIGLCEITNSAMSIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQEVQSKREISRRNPEEFVAHPLNAFSLIRRLHEDWTQAELLMLNQVGLEHLQAIETGLEEAQPSDNDLNDAIGGIISLQQFYNLQPSDIANGLLMGQQYNASLTTLNCQALANACMNFNYDKYALNWFKAAVDHYNDDRDGQVYREVFDFRLPDLYINYTSVLVTKGFRKAAWKVLQDVADLDATLWLLRKDIYEVGKIDVPDPTFIITPWFDVTGCLRVGQTSQHLSCHYEKNTSEFLRIAPLKVETLSLKPHIVLYHDVIYDSEISKVKNISLPSLKSPLRILYAIDYNLKFAKIREDHQSPLSLRIKDMTGEDVQEDTDFQIDNYGICGFRNFHTDNIELQDQTAELGDRLTSIMFFMNDVAQGGALAFPNLNLTIWPQKGSALVWRNLDHRMQPNQDLLHVSCPVVVGSKWTLVKWLHERPQMFSRPCTTGRKFKSHDQSMKFRALNK
The following text describes a protein:
Function:
Exhibits 3'-exonuclease activities and apurinic/apyrimidinic (AP) endonuclease (in vitro). Show preferential AP endonuclease activity on double-stranded DNA substrates and 3'- exonuclease activity on single-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MRAAGVGLVDCHCHLSAPDFDRDLDDVLEKAKKANVVALVAVAEHSGEFEKIMQLSERYNGFVLPCLGVHPVQGLPPEDQRSVTLKDLDVALPIIENYKDRLLAIGEVGLDFSPRFAGTGEQKEEQRQVLIRQIQLAKRLNLPVNVHSRSAGRPTINLLQEQGAEKVLLHAFDGRPSVAMEGVRAGYFFSIPPSIIRSGQKQKLVKQLPLTSICLETDSPALGPEKQVRNEPWNISISAEYIAQVKGISVEEVIEVTTQNALKLFPKLRHLLQK
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase. Appears to be required for normal cell-type proportioning and cell sorting during multicellular development. In addition to being necessary for a normal percentage of prestalk cells and the organization of the slug, rbrA is also necessary for spore cell viability.
Domain:
Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
Sequence:
MTDDEMYEDYDVDDDSAEESGNESLDDTEYDDAATQEFDFDENQPQRSLGKLTRQKSFEVLNKDDLFSESHKIIKEVKDVLSIPSEAAVSTLLRHMKWNKEKLIERYMENPEKLCIDAGVPNVMKLNATIVEKSGNVSCLICLEDYPPTQTFALICNHRYCLPCYKNYLEIKVSEGPECIYTPCPAPKCKVIVHQDAFKQIVSPEVFERFNNFILKSYVDDNPQVKWCPAPGCIYSIRCDRKERKEAVNCKCGFQYCFNCNDYEIGDHMPCPCSQVDKWLQKASDESENVTWMLANTKKCPECRSPIEKNGGCMHMTCRKNAGGCGFEFCWLCRGPWTEHGSTTGGYYNCNKYDKSKAKEDDDKAHDAKTELEAYMFYYHRYESHRNAMKIADEQRRNAHLKEQQILSKFDVRSADTKFLMEATEQLLKNRRVLQYSYVYGYYLDKKSQERNLFEYLQEDLEKHTNLLSTQYEQSLDKLEDYQAFIKWKEQVTNYTRITKKFLDNFVDGVAGGLVNTQIN
The following text describes a protein:
Function:
Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Promotes the localization of brc-1 to the short arm of homologous chromosomes during meiotic prophase I. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor-mediated sensitivity to nicotine but not levamisole. Regulates motility.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Chromosome. Note=During meiosis I, localizes to chromosome pairing centers formed at the nuclear envelope in early pachytene and then to the synaptonemal complex in mid and late pachytene. Co-localizes at pairing centers with him-8, zim-3, zyg-12 and sun-1 and partially with plk-1 in early prophase. Co-localizes with syp-1 in synapsed chromosomes at pachytene. Co-localizes with brc-1 in pachytene nuclei. Localizes asymmetrically in the 1-cell embryo which results in higher levels in the somatic cell AB than in the germline blastomere P1.
Sequence:
MQRVQPSAARVKSQKKEKAPPDVPDVILDGERKTRYEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRRSLMELHKRRKAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDNDERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGHPPFESKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCRDHFFKSGFMPARLPVSCLTMVPHLNDDEYAEENVSPSGTIDQRGPHQAGRSGLSAIPAHLVSRNSERQQTHRMEAYRQPTDCYLSNLLAQVNDLLATPTADIDDAEAALDSYQSPEALPVFWISKWVDYSDKYGIGYQLCDNSVGVLFNDNSRIMLDTAGTQLTYIEKTEKEHYFDMESAIPSGLQKKMTLLKYFRSYMNDHLLQAGQQVTRKVGDDLARLPTLRVWFRTKSAIVLHLSNGTVQINFFNDHIKMVLCPLMQAVTFIDENKRMFTYKFSHLAENGCPEKFLHRIQYAKCMIQRLVEEHTKEETKHNAPAANAVRLPSTSSNVRLESAADIQPAYPSSSRR
The following text describes a protein:
Function:
Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.
Subcellular Localization:
Cytoplasm, Stress granule. Nucleus, nucleolus.
Sequence:
MREKGKNPENQLSDQEILSLREKDFRLLMLKMMQDIGNKLEAKMDNLQKTLSKEIQDIKVKQEEMQNTTTEIKNSLEAANSRIQEAEERISKVEDRLVEITDAEQKREKRRKRNEESLRELWDNVKHTNIRIIGVPEGEEREKGTEKIFQEIIAKNCPHMGKEPLTQIQEAQRVPYKINPRRNTPRHILIKLTKIKDKQKISKAAREKKEHTREPQ
The following text describes a protein:
Function:
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HGA) to 2-oxoglutarate. Appears to be the only D2HGDH in E.coli, providing the way to recycle D-2-HGA produced during L-serine synthesis by SerA, by converting it back to 2-oxoglutarate. The physiological molecule that functions as the primary electron acceptor during D-2-HGA oxidation by YdiJ in E.coli is unknown. Shows strict substrate specificity towards D-2-HGA, since it has no detectable activity on L-2-hydroxyglutarate, L-malate, D-malate, L-lactate, D-lactate, L-tartrate, D-tartrate, L-glycerate, D-glycerate, glutarate, or pyruvate.
Sequence:
MIPQISQAPGVVQLVLNFLQELEQQGFTGDTATSYADRLTMSTDNSIYQLLPDAVVFPRSTADVALIARLAAQERYSSLIFTPRGGGTGTNGQALNQGIIVDMSRHMNRIIEINPEEGWVRVEAGVIKDQLNQYLKPFGYFFAPELSTSNRATLGGMINTDASGQGSLVYGKTSDHVLGVRAVLLGGDILDTQPLPVELAETLGKSNTTIGRIYNTVYQRCRQQRQLIIDNFPKLNRFLTGYDLRHVFNDEMTEFDLTRILTGSEGTLAFITEARLDITRLPKVRRLVNVKYDSFDSALRNAPFMVEARALSVETVDSKVLNLAREDIVWHSVSELITDVPDQEMLGLNIVEFAGDDEALIDERVNALCARLDELIASHQAGVIGWQVCRELAGVERIYAMRKKAVGLLGNAKGAAKPIPFAEDTCVPPEHLADYIAEFRALLDSHGLSYGMFGHVDAGVLHVRPALDMCDPQQEILMKQISDDVVALTAKYGGLLWGEHGKGFRAEYSPAFFGEELFAELRKVKAAFDPHNRLNPGKICPPEGLDAPMMKVDAVKRGTFDRQIPIAVRQQWRGAMECNGNGLCFNFDARSPMCPSMKITQNRIHSPKGRATLVREWLRLLADRGVDPLKLEQELPESGVSLRTLIARTRNSWHANKGEYDFSHEVKEAMSGCLACKACSTQCPIKIDVPEFRSRFLQLYHTRYLRPLRDHLVATVESYAPLMARAPKTFNFFINQPLVRKLSEKHIGMVDLPLLSVPSLQQQMVGHRSANMTLEQLESLNAEQKARTVLVVQDPFTSYYDAQVVADFVRLVEKLGFQPVLLPFSPNGKAQHIKGFLNRFAKTAKKTADFLNRMAKLGMPMVGVDPALVLCYRDEYKLALGEERGEFNVLLANEWLASALESQPVATVSGESWYFFGHCTEVTALPGAPAQWAAIFARFGAKLENVSVGCCGMAGTYGHEAKNHENSLGIYELSWHQAMQRLPRNRCLATGYSCRSQVKRVEGTGVRHPVQALLEIIK
The following text describes a protein:
Function:
UV-B specific signaling component that acts as a UV-B photoreceptor and plays a key role in establishing UV-protective responses in plants. Upon UV-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, accumulates in the nucleus, interacts with the photomorphogenic repressor COP1 and regulates the expression of the transcription factor HY5 by associating with chromatin (through histone H2B binding) in the HY5 promoter region. UVR8 is involved in controlling aspects of leaf growth and morphogenesis in response to UV-B, is required for normal progression of endocycle and has a regulatory role in stomatal differentiation. Is required for plant circadian clock response to photomorphogenic UV-B light, partly through the transcriptional activation of responsive clock genes. Promotes photosynthetic efficiency at elevated levels of UV-B. Plays a role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway. The two tryptophans, Trp-285 and Trp-233, serve collectively as the UV-B chromophore.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Note=UV-B promotes rapid accumulation of UVR8 in the nucleus.
Sequence:
MAEDMAADEVTAPPRKVLIISAGASHSVALLSGDIVCSWGRGEDGQLGHGDAEDRPSPTQLSALDGHQIVSVTCGADHTVAYSQSGMEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGIRIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRTDRLVPERVTSTGGEKMSMVACGWRHTISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEALSNSFISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGNNLDQCSPVQVRFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESVDRNFPKIIEALSVDGASGQHIESSNIDPSSGKSWVSPAERYAVVPDETGLTDGSSKGNGGDISVPQTDVKRVRI
The following text describes a protein:
Function:
Probable transcription factor involved in the development of the adult pattern of macrochaetae. Required for accumulation of achaete (ac) and scute (sc) in proneural clusters. Probably acts by binding to the proneural cluster-specific enhancers of the ac/sc complex and increasing enhancer efficiency, thereby acting as a stimulator of ac/sc expression in proneural clusters. Also required for correct development of the embryonic/larval peripheral nervous system (PNS).
Subcellular Localization:
Nucleus.
Sequence:
MATLIPVNGGHPAASGQSSNVEATYEDMFKEITRKLYGEETGNGLHTLGTPVAQVATSGPTAVPEGEQRSFTNLQQLDRSAAPSIEYESSAAGASGNNVATTQANVIQQQQQQQQQAESGNSVVVTASSGATVVPAPSVAAVGGFKSEDHLSTAFGLAALMQNGFAAGQAGLLKAGEQQQRWAQDGSGLVAAAAAEPQLVQWTSGGKLQSYAHVNQQQQQQQQPHQSTPKSKKHRQEHAAELIYASPSTSANAAQNLAQSTPTSAPSNSSGGSTSSSGGGGGRKKAAQAAAAAAAANGVHIQKRYACTHCPYSTDRRDLYTRHENIHKDEKPFQCYACLKQFNRADHVKKHFLRMHRELQYDINKTRRHVSAGSGSSGSGSSGSGSHHSGGRGNVTINSAGVNIDNAFLEAQRHPTSSSMSIVETIEAVASATDMPLAQLKQEKMDDGAGVVLPLHVGVMQQPVASSSSGSSGSHGGNGNGGSGSGLLKPKREKRFTCCYCPWSGADKWGLKRHLNTHTKPFVCLLCDYKAARSERLATHVLKVHNKRACSKCSYLADTQEEYQAHMSDVHGNVGNANGGGGAVTIYTTTTNEGVAGGGGGGGGGISGNISGGGPLQEIIVNPSSMVGWRLSANGSLIPPHDLLTGGLPNAATQKRGSERLFQYLEAEGSDPEDYARLLKMDAISRNTASVAQDFHKAGGVHELKIPANHQLLFNNKLPSQWTTREAAALLYSLSNMGGGSASSVSGSQRQKFGMRARQHSTGEDDENTPSSASSSSFSGDEFNMSATSPLKLSRHAIKLEKMDEMDAKDMGPTKAMMATAFLEAANYEQTAIELLASKRKIKVENDNDEDQENQQHQPHQQHHSQQQQQQRLQLIKSSPAYKLNNNNNNNSNNNNYYKDKTSHRNAVHHHRQDDKENNKTKSPGTAAVSVAAAAATSPPSISGPSNQTPFLTQMEYQNLNRIGTQFQNYVKDIINKYYAAETPLMLAAAAAALPTATTTGQQQQPELDIENLSPSKRRRLLSETEEYIEYLRNKEDITLTIAPKVQPPAPVTSLLKRQLDLSTPRRSPKKAAPAHSNSASNASRKSLNQLATLLPLLADAASQQEYLAAPLDFSKKSSSRKQAQPKKIRLTPEAVVTLLRDKYLNRMVRQRLGCLKCNQLRKNSSISFNYHTLGSLALHKYWRHGRLGSSSTRREKLQAALQKRISRGQADKC
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTISSTTKRVLCFGSINIDDVFTVPDIAKPGETISCSDYKMLPGGKGANQSVALAKAGTSVVHGGKIGKDGQWVLDLMKDYGVDTSMVVVDHNAGTNESSLLDVLLSKVSQASHDNTIVLNPGANHQITAQDIDKVLSQFKSRDFVILQNELNSDATLYLLKSCSAKGMVVCLNPAPCPKNLASVLPLELVDILILNESESESLVCQLSTSNVNQKKCNDPATICEIVLTSYPGLSVMVITLGERGLVAGARLHNGAAPTIQSVPITRSVKVQDTTGAGDTFVGFMCGHLISNISLSSDQTHSKTDILTAISAQPNLLEMSLQTGILASGVCCEHSGAMIAIPTKSELMKL
The following text describes a protein:
Function:
Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline.
Miscellaneous:
MISCELLANEOUS: The TrxT gene, which encodes an testis specific thioredoxin, is adjacent to the dhd gene and shares some regulatory region with it.
Subcellular Localization:
Nucleus. Chromosome. Note=Specifically associated with the Y chromosome loops.
Sequence:
MVYPVRNKDDLDQQLILAEDKLVVIDFYADWCGPCKIIAPKLDELAHEYSDRVVVLKVNVDENEDITVEYNVNSMPTFVFIKGGNVLELFVGCNSDKLAKLMEKHAGVYTDEAADVKAVHIDGECIVDLTAESSESDNDNNNVNEVSAHDENAVLEH
The following text describes a protein:
Function:
Mitochondrial mRNA stabilization factor.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MKQALKLAACLRKTTFRRSTFEFLVPLGRKYVTSTAEGSQRSAKKLWYQSDKHNIFPSIKKIDIEIPKLPKNTPLFVEKLLLHLAKDSFVFDLSCVRPRAETKLQSECVFLIIGSCRNESHIISASKSLKQLLKDTKKYHYDTQGLPPSANYKRAQERRLRKNPRYDSIINHTSACLWTCTYIEELNVYVHLLTPKKREEVQLELLSDDHQALFHDGTHLSAVRSPSANSVEVEEQNGMSREEIFKKIMLACNDMNQAFCHKHGFLLSHINSSQLSTIEKEEFSSVSVRDLLLQAATAKCDPNSHKDPEAIVSLRFKQVCLLYQTLRDAQIVSKQTLQNLFVRALLIASFIESSSTTENPYLDYRFRKIDQLIRRQGVQYNREDIKIIIHILVSTRNWTALRKRWNELKVASIERDLDLYTYLFQQVANSKSQCASDYLITYILEDLKCEIPTYTSSTVLKKYIDICRKNTRSTNTTVDQSPLNSVL
The following text describes a protein:
Function:
Transient kinetochore component required for chromosome and spindle pole alignment and chromosome segregation during mitosis. Functions downstream of the RZZ complex to mediate kinetochore-microtubule attachments and nuclear envelope breakdown during cell division. Required for kinetochore assembly and localizes the checkpoint proteins mdf-1 and mdf-2, dynein and dynactin to unattached kinetochores. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Required for embryonic development.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Localizes to microtubules during mitosis. Recruited to the kinetochore by the RZZ complex. Localization to the kinetochore is also dependent on the NDC80 complex and bub-1. Localizes to the kinetochore during nuclear envelope breakdown and remains there until the metaphase-anaphase transition.
Sequence:
MPDDEEKLQLLADVERLKKILRQKDEMLEEMEDDLKNQGKPCSSKLSLEERAQELSEQLRDLHVEMDGKNATILDRDALIDSLRSEIDKLEKINKEFANGSVIPEHDDSNSFGESEMLRISEDCQKYKETATALYERNAELEKEAVNLKDEIESMMDHIRDLKNHMETRDEEIARLEGELFDERNSHEGKLAARGNSMFSEVIDAERKVEEDLKVLHGENRALKGMVKRLRMEVEEVEERLRSSTKRFNVTRMTTSDIDVKEMRRLRDRVCHLETERVHLWERMFIKMRSIPKREVGALITGYFKSFELSIASVKGGFDGLMKDNEKYVTIIRGLQQEVENLKADIVQLQFDNKCAHRKAAPVVNKDFEHPLLAAPLKTLNNGRPSFFIKPKNVEPMPQLGHSLSSIAVTPQKPAAKFTTRSSIKDDTSEWAERRMKAQAEKKLATPTPRYNYIKLSEPVPKFKPAVLQMPSTSETKEN
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAKIVGIVLGLLVIADTLRSGHAAGTYGVTKASWQPLCEATTDLRTIPSDVAANLKAGVTKVKNMILDSTRAAIYSQLQKGTKEAARVITISLYMLGAALRAVSYLESTDIINGVDLAAKSAYLKGHIDEFLKVAEKTTRSGEHCLLAAGDTGAATFAGESLNRVNCPTTMVDTTPTKASLKKLSSKGHKGAMTPSNGGSHEHQASGTYRCRLFSKSNANGLAHSGGNVEDGIKWAGGYYSLHSTPDNPLTVADLRETPDTPREASTAWQQVFTAISKAPNSESATYTNNSKAIDSDTEATELLSQVLHNEKGENAEDIKKMRDDIFTTKLASVVDSTFANIHNAKLPAKISGIDKGKSLGEITAPSDLAALLAALLRKIDTEVATLKKKLETTNERPDPVSEATCNTIKGEADCNRAAACRYNTTETYENKKFQFNASKASASGVPAPQPQTGGTETTTEKCKGKGEKDCKSPDCKWDGKECKDFSFLVNMKLALSISAFMSLVAF
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
Sequence:
MGQEKLYTEKELSWLSFNERVLQEAADKSNPLIERMRFLGIYSNNLDEFYKVRFADLKRRILINEEQGSAVTSRHLLKKIQSKVVKADQEFDGLYNDLLLEMARNQIFLVNERQISENQQTWLKQYFKQHLRQHITPILINHDTNLVQFLKDDYTYLAVEIIRGQDIAYALLEIPSDKIPRFVNLPPEAPRRRKPMILLDNILRFCLDEIFKGFFDYDALNAYSMKMTRDAEYDLVTEMESSLLELMSSSLKQRLTAEPVRFVYQRDMPDEMVELLRNKLGISNDDSVIAGGRYHNFKDFINFPNVGKSNLVNRPMPRLRHVWFDKFRNGFDAIREQDVLLYYPYHTFEHVLELLRQASFDPSVLAIKINIYRVAKDSRIIDSMIHAAHNGKKVTVVVELQARFDEEANIHWAKSLTAAGVHVIFSAPGLKIHAKLFLISRLENDEIVRYAHIGTGNFNEKTARIYTDYSLLTADARITNEVRRVFNFIENPYRPVTFDNLMVSPQNSRLILYQLIDQEIIHAQAGESAGITLKINNLVDKGLVDRLYSASSAGVKIRLLVRGMCSLIPNMPGISDNIQVTSIVDRFLEHDRVYVFENKGDKLVYLSSADWMTRNIDYRIEVAVSLLDPKLKQRVLDILEILFNDTVKARYIDKELSNRYVPRGNRRKVRAQIAIYDYLKALEQPEQ
The following text describes a protein:
Function:
Involved in resistance toward heavy metals.
Subcellular Localization:
Cytoplasm.
Sequence:
MILVYSTFPNEEKALEIGRKLLEKRLIACFNAFEIRSGYWWKGEIVQDKEWAAIFKTTEEKEKELYEELRKLHPYETPAIFTLKVENVLTEYMNWLRESVL
The following text describes a protein:
Function:
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity).
Subcellular Localization:
Nucleus. Golgi apparatus, trans-Golgi network.
Sequence:
MESEQMLEGQTQVAENPHSEYGLTDSVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPTEFLASYLLKNKAQFEDRN
The following text describes a protein:
Function:
Probable transcription factor that controls female gametophyte (megagametogenesis) development and chloroplast biogenesis during embryo development.
Subcellular Localization:
Nucleus.
Sequence:
MVKKTLGRRKVEIVKMTKESNLQVTFSKRKAGLFKKASEFCTLCDAKIAMIVFSPAGKVFSFGHPNVDVLLDHFRGCVVGHNNTNLDESYTKLHVQMLNKSYTEVKAEVEKEQKNKQSRAQNERENENAEEWWSKSPLELNLSQSTCMIRVLKDLKKIVDEKAIQLIHQTNPNFYVGSSSNAAAPATVSGGNISTNQGFFDQNGMTTNPTQTLLFGFDIMNRTPGV
The following text describes a protein:
Function:
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
Sequence:
MVSETFDDAAWTAIEEFSFDDITYHRGVEVPAVRIAFDRPAVRNAFRPGTVDELYTALDHARKQADIGCVLLTGNGPSPSDGGWAFCAGGDQSVRGDSGYEYHGDDEAAADDDPAVKRADAGRLHILEVQRLIRTMPKPVVAVVPGWAVGGGHSLHVVCDLTLASREHAKFKQTDPDVASFDGGFGSAYLAKQVGQKTAREIFFLGKTYDAEAAADMGMVNEAVPHDDLEATALEWADEMTAKSPTAMRMLKYAFNMTDDGMVGQQTFAGEATRLAYMTDEAQEGRDAFLDGRDPDFDEYPWHY
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity).
Subcellular Localization:
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring. Nucleus. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis.
Domain:
The UEV domain is required for the interaction of the complex with ubiquitin; The coiled coil domain may interact with stathmin.
Sequence:
MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTAAGPPNTSYLPSMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTAGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY