lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MGKKKRTRAAPPKKAGRSKFFPCPVCNTIESVGSERISKEGVFVLTCKMCKERYTYKYGLLDTPNEAHRSWGDFIYKKKKYGVPCPGFGDCKCNFKGIAIIDFFTERDEGTGIENYYARLTCGECGTSIRPLYTNETKAEFKKRMEQEHARGRDERRKRENDDNYDARLVSPEAPVNDYNDYKGDASKKRPRNRGDSSHRKESSSSDILDDDQEIASQISEPRSEDDI
The following text describes a protein:
Function:
Forms part of the erh1-mmi1 complex that recruits the CCR4-NOT complex and the NURS complex to target RNAs. Suppresses the meiotic program during vegetative growth and promotes the meiotic program during mating. Recruitment of the NURS complex to target mRNAs promotes mRNA decay by engagement of the nuclear exosome, and formation of heterochromatin islands at meiotic genes silenced by the exosome. Recruitment of the CCR4-NOT complex to target RNAs promotes heterochromatin formation at RNAi-dependent heterochromatin domains (HOODs), including a subset of meiotic genes, lncRNAs and retrotransposons. Recruitment of the CCR4-NOT complex to rDNA promotes rDNA heterochromatin assembly.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to chromatin regions during vegetative growth, localizes to mei2 nuclear dots during meiosis.
Sequence:
MSPPPAESHIILLIQQGSDPKTRIWSDHCSLRSAIEYIVGVYQTNQAVSEKESIDVSRFFNFFDEIYDCVPLVYDRHFRAYIPHEKQWLLHHAQEYLTAARQIP
The following text describes a protein:
Function:
Catalyzes the oxidation of pyridoxine 5'-phosphate (PNP) into pyridoxal 5'-phosphate (PLP). Unlike many PNPOx enzymes, Rv2607 does not recognize pyridoxamine 5'-phosphate (PMP) as a substrate.
Miscellaneous:
MISCELLANEOUS: The electron density for the FMN cofactor is weak in the crystal structure (PDB 2A2J), which does not allow FMN to be definitively placed in the M.tuberculosis PNPOx active site, but the residues known to interact with FMN in the E.coli and human PNPOx enzymes are found to be conserved.
Sequence:
MDDDAQMVAIDKDQLARMRGEYGPEKDGCGDLDFDWLDDGWLTLLRRWLNDAQRAGVSEPNAMVLATVADGKPVTRSVLCKILDESGVAFFTSYTSAKGEQLAVTPYASATFPWYQLGRQAHVQGPVSKVSTEEIFTYWSMRPRGAQLGAWASQQSRPVGSRAQLDNQLAEVTRRFADQDQIPVPPGWGGYRIAPEIVEFWQGRENRMHNRIRVANGRLERLQP
The following text describes a protein:
Function:
Putative FAD-dependent oxidoreductase.
Sequence:
MAAAASPAVIARILKRKEQEKKQKQHQHHHHHHRHSKRRGSHQGSNRTPSPATSPKGSPSTSPTSHFPVSPRRGSHPSPRISPKHPRPRRGSSPNPVGSASLPSLPSSHTNNLLTPSQSHSPAGSPVEQHDRTITDLTFVFGKNGSAHHKGSNHSRDASPKVSPGASPKSSPKKSHAKSNGSEEQANAHVVIVGGGYAGIAIARKLQGKINFTLIDPKECFHHHIGALRSAVRTDFAKKTFIPYDATFGKRFKQGRVKDVNTSDRTIILETGETISYTHLVIATGCTGPFPGRVDDTITTDEAISRYNNLAEQIETADKIVIVGGGVAGIELTGEILSAHKNKNVTLIHAHQHLINDDVLPGMRTKLHEKLARYGVTFILDERVKNLEEVATNVSKPTTVKTDAGTEVSADLVIRCTGVKPNTAVFTNNLGGKLDDSGRLKVNELFEVDGLEHVYAIGECNDVAEVKMPRHSTAQGELLAENIVRKLDNKEMKPHTHGQLMMEISLGPNAGVSQVKGLILGSFLTKYRKSKDLFVHRFWKKVMKQEVPH
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MQVTETLSEGLKHEFKISVPASDLDAKAGAKLVDLKDKVRINGFRPGKVPVAHLKKVYGRSVMAETIDQTIRDTNTQLFSERGFRLATEPKITMPSEQAEVEELLSGKTDLTYTVAIEVVPSIALADFKTFQVEKPVADVTDADVDEAIKRIADTNRGYAAKADGAKAESGDRVTINFKGTINGEVFEGGTGEGIQVVIGSNTFIPGFEEQLTGIGAGETRTLKVSFPKNYMNDKLAGQPAEFETTATSIEAPQDIAIDDEFAKTLGLESLDKLKEAARERLVAEFAGATRQRVKRALLDRLDEAHRFEAPPSLVDEEFNLMWNSVKAEMDSAGKTFADEDTTEDAAKEEYRKIADRRVRLGLVLSEIGEKNKITVTDDEVGRAVIERARQMPGREKEVWDYYRSNAQALAQLRAPIYEDKVVDFILELANVTEKKVSREDLYKDDEAEKTAA
The following text describes a protein:
Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
Sequence:
MKLKETTAKSSVWIFGYGSLVWKPDFKFSRSKVGYIQGYKRRFWHGDNFHRGSNEMPGRVVTLLEDHDACTWGMAYEVTGAQIEESLKYLNVRENVLGGYVTKVVEFFPRDDDEPSILALVYIATSDNPIYLGPASPEEIAAQIAISSGKTGHNIEYLLRLADFMRVCCPEVKDDHLFSIEAAMFSLMPYLITSKRAIPVL
The following text describes a protein:
Function:
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Associated with the endoplasmic reticulum and nuclear.
Domain:
Binds ubiquitinated proteins via its RanBP2-type zinc finger.
Sequence:
MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSSKSLHLLKIKHGDLLFLFPSSLAGPSSEMETSTSVGLKAFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLHEFGAVGGSARAATSAMWACQHCTFMNQPGTGHCEMCSLPRT
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAEQDSADPEAWMGINEDPCGKGGQTLLGSDDLCLDIQRQRFRGVCYRDAKGPREVCRQLSDLCCEWLKPEKHTKAQILDLVILEQFLDILPEEMERWVRECGAETSSQAVALAEGFLLSQEGNQKKEASQEPSKVVMDFSAVEEFLKDTGKEQLSRGTEQESDGGFLSVGNRRIGQDSAAIPSRSPSPCGDIETVTVKSEQSLETFEEMAMQFPAFHQGGLGAVRAKPGGSGEGNHRDQLWSCGNLPSPDVETENNTEAEQLKIKIEEEEDIPIESIDFHETPIPGEYCEGNDKNIPNGEKLLICSDCGKSFSEHVYLTEHRRIHPGGKMCGNQFTHSSDLSLPPGVDATRKLFGCSDCGIKFSDDRSLKRHQRIHAGKKVYKCPECGKSFSRSPELKAHQRVHTGERPYKCSECGKTFSQSSNLSKHQRIHTGEKPYTCSECGKSFNHSTHLKRHQRVHTGEKPYSCSDCGKSFSQSIILKQHKKIHMVENPNKCAECGKSFSSSGNLKTHQKIHRREKPFKCSECGKGFSQSVILKFHQRIHTGEKPYKCSECGKSFGNSRSLKIHQRTHTQEKPYKCSVCGKSFSVRKSLNVHQRTHTEEKPYKCSECEKCFSDSRILKVHQRMHTGEKPYQCSECGESFNQGPHLKRHQRTHTEEKPYKCSECGKSFNQSTHLNSHLQIHTRETAYECSE
The following text describes a protein:
Function:
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication.
Subcellular Localization:
Nucleus.
Sequence:
MEVDADLELLTSLLEENEAAERNGVVSHEASSELDEFDELFDGDEDGSYHGSDNGTEEQTIGGVEEDFTTLFGDIDDIKEEEAAASDTKKQSSSVCQEKSKDELEDELRKMQAQMKKLQEQLQQTALAKTSSPGNPKKSPENKMIQSGKTSRTSPLIERKKTDSNTVAPQLTSPTVPKAKLPDAPKRKPNLSDKSPVQKKMASFLSPPEKSSARPGQSTATQPITNTLKFPVGQQYHVEKFSGLRIRKPRVSSSEMERKMNGRKLIRLAQLQNKIATEKLEEEDWVTFGVIVKKITPQSSNNGKTFSIWRLNDLKDLDKYISLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKEGTDEVCLSVDNPQKVLLMGDAVDLGTCKARKKNGDPCTQMVNLNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVPKKMARGANGLRERLCQGGFHYGGVSSMAYAATLGSTTAPKKTVQSTLSNMVVRGAEAIALEARQKIAAAKNVVQTDEFKELMTLPTPGALNLKKHLSGVSPQANCGKEGQPIQSISASTLLKQQKQQMLNARKKRAEESQKRFLESTEKSEKSSTLTSSACSVFQSPKQGAEFPNAQKMATPKLGRGFAEGDDVLFFDISPPPAPKLSTSAEAKKLLAIQKLQAKGQTLAKTDPNSIKRKRGSSSEELVAQRVASHASTSPKSPDENEPAIKKHRDQLAYLESEEFQKILNAKSKHTGILKEAEVEIQERYFDPLVKKEQLEEKMQSIREQSCRVVTCKTCKYTHFKPKETCVSENHDFHWHNGVKRFFKCPCGNRTISLDRLPKKHCSTCGLFKWERVGMLKEKTGPKLGGETLLPRGEEHGKFLNSLK
The following text describes a protein:
Function:
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MNVQLILRSLTYKEEQRVIIRPIGERVLLKHQKKEEVTKGGIYIPESARQEKKEGIVIAVGTFEDGKELPLKKGDHVIYGGYQADEIEIDDEKYIFVDFKDILATVVEE
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
Sequence:
MAPPLGPRYVRGCVVHAPSRGSIELFEDAFLSIDPESGRIATFHAVTDASDLLLLSKCPASDVLHLPSHQFLLPGFVDTHIHAPQFPFMGTATDVPLMQWLEKYTFPVEESFEDVDMATLWYTKLLDCLLKEGITTAQYFATIHLGATKTLADLVETRGQRGFVGLVSMDRNAPESYKLSTANSLQDAEDFIQYALDKQNDLVKPVVTPRFVPTCSLQLLKGLGELAHKYEVHVQSHIAESMDEEAFVESLHPGRRDTELFGDAGLLTDRSCMAHAVHLTDDELDVMHRTGTSIACCPLSNFFFANGLLDVRKVLDKKVDVGLGTDIAGGYSPSMLRAMQTCVLTIKALEIRDGTSQAPPQPFDFKDAFWLATMGGAKALKIEKDTGSFAVGKCFDAILVDVNCGQNLVFSERDTPMDVFQKVIHNADNRNFAKVFVKGKVVHESSN
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 6000 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLQLRFMPGWVPRNGFFGLKETIGTVHKRFYALASEQPSRKTVKPLDSRKTFLIDTYKHLMENSSMIFFVHYNNLSKTEDHHFRFKIKQTGGKLTKVRNNLFEVYLRNSHLPDPCGFVKRKEQNWKHPLLPLLKGPTATITYEDTNPQQVAKLLKVLQSAQDKLMVIGAKVENEVLNVEKINTFKTLPTKPEMQSQLVSVLQMLSGLGLVRTLENSSNALYLTLKSHNDNQKPKEDVESTTDAESKGSK
The following text describes a protein:
Function:
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MIASKFGIGQQVRHSLLGYLGVVVDIDPVYSLSEPSPDELAVNDELRAAPWYHVVMEDDNGLPVHTYLAEAQLSSELQDEHPEQPSMDELAQTIRKQLQAPRLRN
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MPINNDRKKRPKREYADATQSVEPTMPINDDRKKHPKREYADGSQSNDQKYTQRRDLRSGYLSIQSYIRGRRDEIAAANSKEFISIIDEVDGMHHLVNKPREQVSDAGALRDLASTLVTSIKVHNIGSVTPSLFVSSLISRFGKKKKKKRRITESGQILWKDIGLHASPLFMTFQGPCSMLGHMNHDTQPPKVLVTRKRSRSSLKEKKVNVKPKEIKDTVSKEKTDTEKIIATMFDILKTNKKVCLGNIVLNRISFAQTVENLFALSFLVKDGRVLITVDEKGSHYVSPTNAPYARMITSGKVAYSQFMFKFGFVDWKLMKDSVGGGCELMPHRMKVDSCGGCELKPDLKEGNSHGATITTIKMESRNQEGSHEDGNEQMFIYDKPETLLVYRRRGRRIYKPETLLVYSRRERRKPRT
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGRQKGEGGKGKGRASSSSLAASLLPAGSTATVGFGGYVGGSRLDSSLASDEASSFVDMDGEVAQHLKRLGRKDPVTKLKALASLSVLFKEKPGKDIVSIIPQWAFEYKRLLQDYNREVRRATNDTMTNLVVAVGRDLAPHLKSLMGPWWFSQFDPVSEVSQAAKRSLQAAFQAQEKRLDALMLCTNEIFMYLEENLKLTPQNMSDKAVALDELKEMHQQVIYASLLALATLLDVLVCVQLERPGFENLTVEPKHASKARATAISSAENLFTAHKYFVDFLKSQSPAIRSAAFSVLRSFIKNIPQAFNEVNIKTISGMILGAFQEKDPVCHSSMWDAVLLFSRRFPDSWTSLNVQKVVCSRLWYFLRNGCFGSYQVSYPALVPFLDTVPAKAIEGEKFFLDFFQNLWAGRNPFHSSNANRVAFFQAFKECFLWGLRNASRYCEGVDSIHHFQVNLIDNILVKLLWQDYMFLASLKTPEGVLSGTSAASSEKSNLPSNKKTAETSNIKYPVSYLRDLGKCIIEILSGISLMEHDLLSTFTVEFKENCLGMLQQTENTERSTESVEQIIHFILLLEEHAVHRDENWPLVDLVGPMLALSFPLITSLDSPECVRLLSVSVSVFGPRRILQELFIHNKGHSSSLSGDRGRQLNEEQFIQMFREIFVPWCMHEDNSSTSARLDLLLALLDDECFSEQWGTVITHVTNLEHSGTVPAYRGSNRIAMLAMLLEKARDKITRKVGEDSFSQKGATMDQWHHDDLEIAAVTIASSLPPFRTSDAQFLRAVLGGSKEGDATPFVSRNTLILIFEEVFRKLLSFILESSLTWVRDAGFLLAAREMNFGMELESSSNMYEIGQFALEVLDGSFFCLKTLDEENGLLQCISAAIFIIDWEFSIRTAIDDAIDEKLNKNIEARLNFGESVHAFHCKRSNQFWKSLSIHIRGRLGSILIQCIRSAIFSEDRLDADNITSLCCLWMLEVLECFCQDQDEEQNLLDQLLSKGEIWPLWIRPDFNTPKGAAVLEIENVPSGIHASGSDKFVSFVNKLILKIGIDRVIGLGKHTPSPKEAAYEQVTSRPWLVAEMLCTWKWPGGSAIASFLPLLSSYAKSRSYGFQENLLDSVFNILLHGALVHGGRSAHSFSYVWPASGDDVKDIKEPFLRALVSFLYTLFKDDIWETQKVKTLFEFLVNKLFIGEAININCLRILPPLVNILVRALCQNSIGSGESSMDARLDSPKENHMQDALEGWLQRTLLFPPLVSWKIGEDMEDWFELVISCYPLSASGGIQALKQERNISTVERSLLLELFRKQRHGASASSAANQQPAVQMLLSKLMVISVGYCWKEFDEDDWEFLLSNLRRWIQSVVVVMEEVAENLNDAFVDMSTSDNLDIKLKKLEQIVLVSDSSPIDIATNALLSFSLFSGHLLHQQAEDLNNINPLRTERWDLIKDRILEGILRLFFCTGIAEAIASCCCHQAASIVASHRLEHPYFWELIASSVANSSPHVRDKAVKSVEFWGLSKGPISSLYAILFSSNPVYSLQFAAYFMLSTEPVSNLAITGEGPAMCLDSDSTVDQDPRNPDLSSKQNIHLREEISCMIEKLPYEVLEMDLVAQKRVNVFLAWSLLLSHLWSLPSSSPGRDRLVQYIQDSVSSVILDCIFQNIPVELCMTHSLKKKDTELPAGISEVASAATRAITMGSLLCSMESLWPVEEVKVASLGGAIFGVMLCVLPAYVRGWFSDLRDRSVSSAIESFTRVWCSPPLIANELSQIKKAKFADENFSVSVSKSANEVVATYTKDETGMDLVIRLPASYPLRPVDVDCTKSLGISEVKQRKWLMSMMSFVRNQNGALAEAIGIWKRNFDKEFEGVEECPICYSVIHTTNHSLPRLACKTCKHKFHSACLYKWFSTSHKSSCPLCQSPF
The following text describes a protein:
Function:
Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for the translocation of the substrate across the membrane.
Miscellaneous:
MISCELLANEOUS: Maps to a phosphate-starvation-inducible locus previously known as psiC.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLIWSPKGRAAAGVVASVLFIVFFFLPLAVILMSSLSQQWNGILPSGFTLNHFVNALHGAAWDALLASLTIGFCASLFALLCGVWAALALRQYGVKTQKWLSMVFYLPSAIPSVSVGLGILVAFSQGPLQMNGTLWIVLTAHFVLISAFTFSNVSTGLARISADIENVASSLGASPWYRLRHVTLPLLMPWMMSALALSLSLSMGELGATMMIYPPGWTTLPVAIFSLTDRGNIADGAALTIVLVAITLLLMMKLERIAKRLGQK
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MTPSRIHRLTLTHFRNYRAAGLETAADMVALVGPNGAGKTNCIEAISFLSPGRGLRRATLEDVADNQGDGSWAVSAQVEGALGLATLGTGIEPPRADAAVSRRCRIDREPVNSAAAFGDHIRMVWLTPAMDGLFMGAASERRRFFDRLVLAIDSEHSSRINALERSLRSRNRLLETRNYDDHWCDAIERETAELAVAVAATRGQTAARLTGMLSARAQASAFPSAQIALDGWMENALLRETATSVEDRYRQILRDNRPRDAIAGRTTDGPHLTDLQVIYAPKGMPARDASTGEQKALLIGLVLAHATLVAEMTGIVPLLLLDEVVAHLDPNRRAALFEELKKLGAQVWLTGADPAAFAEIGAGGEVFDVESGRVSARR
The following text describes a protein:
Function:
Seems to have a role in regulating nitrogen assimilation.
Subcellular Localization:
Cytoplasm.
Domain:
The EIIA domain is phosphorylated by phospho-NPr on a histidyl residue.
Sequence:
MPITDLVAPEAILPALKVNSKKQALQELAAKAAELTGQNERAVFEVLLQREKLGTTAVGYGVAIPHGKLPKLEKIFGLFARLDRPIDFESMDGQPVDLVFLLLAPEGAGADHLKALARIARLLRDQDIAKKLRASRDAQAIYSVLALPPATAA
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Transcription repressor that prevents expression of pathogenesis-related genes (PR) via histone modifications and binding negative cis-acting elements at their promoters. Negative regulator of hypersensitive response (HR) and systemic acquired resistance (SAR) required to dampen the basal expression of pathogenesis related (PR) genes. Functions synergistically with NTL9/CBNAC as negative regulator of pathogen-induced PR1 expression and basal resistance to a virulent strain of P.syringae. Binds to the PR1 gene promoter to suppress defense response in the absence of pathogen challenge and is removed in response to induction. Negatively regulates both gene expression and DNA recombination during pathogen infection, thus being involved in short-term defense response and a long-term survival strategy. Prevents effective immune responses that involve activation of DNA damage responses, probably by negatively regulating the DNA damage sensors RAD17 and ATR. Negative regulator of defenses against the beet cyst nematode H.schachtii.
Subcellular Localization:
Nucleus. Note=Also detectable in some fluorescent loci peripheral to the nucleus.
Sequence:
MSKETKGNNNTSRVMSGYGGSLEANTLAMIDSTGAKDSRDANEDRLQYLEAVRAASLVPENGIPPTNKMYQAIFRILRFGKTLELITASFQLLTQLHQRFPWVYVSDSADQLDIVDEAWSPFNFGSDVDSDEKDLSVRSLFLQQLIQNMNKRVNESEESDLKILGNMFLFKYLAHVLKLDFTPRNQVYEETMNWSLLKESFLNLLLASRKVNFKLLMKDYLSTMCASIDADEKSISLVELHKDMLTAMKELLVMIMELDTSKKKADLEGITSRGDGVRTPAMEIILDELTYDGYLLSKFLQVFDDPKWKLEIVLQYLTKYIPKPVVRTRRTTVPQAEDSKTLNGILKTFSNGTNPKNITKKIGPDIVQILIGHAFLARLTFSDPHEGDSISEICSSIISAFTSLKRVDQKIEILPFGKEVLFTAGMVLKAKA
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKKYPRILFRKRLKDLRKDMEEVSQKTLKTHKLAVDLLMEYDEEKKEKVIKNSRAIDDMVFNLERKAISLIAAEQPVAGDLRFIEACIKVGSHLKRIGYLAANIAEAAEKLKDEEIPRRPLEDLKHMSDFVQMMLSKGIYAFLDQNMEMARELRHDDDKVDDLFDQTLEHVTRSMFEDKESISYLVNLLFIARFLERVGDRAVSIADRTIFMITCEKP
The following text describes a protein:
Function:
CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Required for antisense-RNA-mediated gene silencing.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized in the cytoplasm when associated with CPSF30.
Sequence:
MGTSVQVTPLCGVYNENPLSYLVSIDGFNFLIDCGWNDLFDTSLLEPLSRVASTIDAVLLSHPDTLHIGALPYAMKQLGLSAPVYATEPVHRLGLLTMYDQFLSRKQVSDFDLFTLDDIDSAFQNVIRLTYSQNYHLSGKGEGIVIAPHVAGHMLGGSIWRITKDGEDVIYAVDYNHRKERHLNGTVLQSFVRPAVLITDAYHALYTNQTARQQRDKEFLDTISKHLEVGGNVLLPVDTAGRVLELLLILEQHWSQRGFSFPIYFLTYVSSSTIDYVKSFLEWMSDSISKSFETSRDNAFLLRHVTLLINKTDLDNAPPGPKVVLASMASLEAGFAREIFVEWANDPRNLVLFTETGQFGTLARMLQSAPPPKFVKVTMSKRVPLAGEELIAYEEEQNRLKREEALRASLVKEEETKASHGSDDNSSEPMIIDTKTTHDVIGSHGPAYKDILIDGFVPPSSSVAPMFPYYDNTSEWDDFGEIINPDDYVIKDEDMDRGAMHNGGDVDGRLDEATASLMLDTRPSKVMSNELIVTVSCSLVKMDYEGRSDGRSIKSMIAHVSPLKLVLVHAIAEATEHLKQHCLNNICPHVYAPQIEETVDVTSDLCAYKVQLSEKLMSNVIFKKLGDSEVAWVDSEVGKTERDMRSLLPMPGAASPHKPVLVGDLKIADFKQFLSSKGVQVEFAGGGALRCGEYVTLRKVGPTGQKGGASGPQQILIEGPLCEDYYKIRDYLYSQFYLL
The following text describes a protein:
Function:
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs (By similarity). Can increase in vitro the expression from reporter constructs that contain leader introns required for the expression of different genes. In association with MAGO and PYM, participates in intron-mediated enhancement of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Can shuttle between the nucleus and the cytoplasm, but is mainly cytoplasmic.
Sequence:
MGSRSGEQGKRMAELSKNLKEGERILEPTRRPDGTLRKPIRIRPGYTPEDEVVKYQSKGSLMKKEMASQGPPGYEPDPAPKPKTKAAKRNERKKEKRLQATAEKANSSEDGSASNGSQSVNVLASEMEALDVSSNNDVCGGAPNPGTTGEDVEKRIRALKKKIRLTEAQQQKTASRDLNPEQLEKFSKLEEWRQELKALEDKAA
The following text describes a protein:
Function:
Atypical bHLH transcription factor that regulates photomorphogenesis through modulation of phytochrome (e.g. PHYA) and cryptochrome signalings. Suppresses the transcriptional regulation activity of PIF4 by forming non-DNA-binding heterodimer.
Subcellular Localization:
Nucleus.
Sequence:
MSNNQAFMELGWRNDVGSLAVKDQGMMSERARSDEDRLINGLKWGYGYFDHDQTDNYLQIVPEIHKEVENAKEDLLVVVPDEHSETDDHHHIKDFSERSDHRFYLRNKHENPKKRRIQVLSSDDESEEFTREVPSVTRKGSKRRRRDEKMSNKMRKLQQLVPNCHKTDKVSVLDKTIEYMKNLQLQLQMMSTVGVNPYFLPATLGFGMHNHMLTAMASAHGLNPANHMMPSPLIPALNWPLPPFTNISFPHSSSQSLFLTTSSPASSPQSLHGLVPYFPSFLDFSSHAMRRL
The following text describes a protein:
Function:
Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MATPTVNVVRWSALIAGITYGIFHQSTLQAKYDEDKVKHHAAHRAHLVEEAKKAYAAKKAAQSGGSSLITDPEDPKFDLEKVIKSWTKDS
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Sequence:
MKLLVCLENSGLLKEVKVSLATGDHKVRDVGFSEGSAVHVSKVIYDQRQYVALGRRDGSVEVLDVEMGTPRRLYPAHREVFHPSELFASIDYAHNLLYTCTTGGMVTVRECKLDQTQTSDELLSTHHLGDAVSVLRPHPTQRGVVAFGGPQRVLEVAIIRTNRRNLWRSSKEEYIWISDVRFTNVRGTSDNAEPGYSLVAVSRYGDAYIYQTNVSARPVRKIQVGDYPLTHLHMNHSLGGDAFYVANSQNQVSLVDYDGQVRHKVCMPEGSVFLADFFSPATRQDPRVPQTEPIPSTSISRGDNLQSALWGELLMRRRQHTRQQQLQNQNQSTEPDPDADNTDHYVLNDDTHSDEAPRRPPFDRRYFERVLGLSRPRIQITTGGEDRARREASRELRREERRLRMIRAAPGNLSYSSFGQGPLVRRHQRWSPLTLARDLQTIRRPETASGQAWTRDTDDLIANPSASLRASRDSDFFRELWCDDDEQSLMYFNTLSSVHLPNEGEEEEEEEDEDEEELTVRESDTEELFAPGILGGSSEIVDRFMPPHLQTSRTTAPLQPSMGRFVGGVQYESRASGLDLTVVAGLDRHVRVFDISQPSIASRGRLLFDIAFESRITSVAILEVSEEDICEKTKRAASPVSRDTKRQRV