lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle. May also regulate more or less directly Golgi biogenesis (By similarity). Indirectly regulates axonal development (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, axon. Note=Localizes to endoplasmic reticulum tubular network.
Domain:
The N-terminal hypervariable region (HVR) regulates ATL1-mediated membrane tethering by organizing ATL1 into a lattice structure on the same membrane. It does not affect GTP hydrolysis or membrane fusion. It has no effect on the GTP hydrolysis and fusion steps; The GB1/RHD3-type G domain mediates GTP-binding and hydrolysis as well as homodimerization; The two three-helix bundle (3HB) regions in the homodimer are loosely associated initially, but they tighten upon GTP hydrolysis, facilitating the fusion of membranes; The C-terminal autoinhibitory domain negatively regulates the GTPase-dependent fusogenic activity without affecting GTP-binding.
Sequence:
MAKNRRDRNSWGGFSEKTYEWSSEEEEPVKKAGPVQVLVVKDDHSFELDETALNRILLSEAVRDKEVVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDHNEPLTGFSWRGGSERETTGIQIWSEIFLINKPDGKKVAVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLSQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGSDGGSKFLEKRLKVSGNQHEELQNVRKHIHSCFTKISCFLLPHPGLKVATNPNFDGKLKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLELKEESVKLFRGVKKMGGEEFSRRYLQQLETEIDELYIQYIKHNDSKNIFHAARTPATLFVVIFITYVIAGVTGFIGLDIIASLCNMIMGLTLITLCTWAYIRYSGEYRELGAVIDQVAAALWDQGSTNEALYKLYSAAATHRHLYHQAFPAPKSESTEQSEKKKM
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MASIFLNKKTIETNNFIFNDNRPKNIKIVDKIKSSTVEFFHSIQKHIQQVKVENNNNNNNNNNNSENNKYKRSQSEENINNYIQNHFNPPQPQKKRNILFIFQNLINSGNSNNNNSSNSSCNSTPSTSPSSTPRSTNSPRSTYSPRNNNNNFTESSSDNQQFDITFNMVVEKERVILTVKVPEVGLTKKILFDKVETIKDAILLVIEKLPPGCLDASEYNLFLPQKNQWCKIDSRFSKYQFKENQEIEFKKDSRGGVSHMLSNVGNLLTRPYRTIYIKLPEIVTVGTLPPLQINGQIGDLPSLNNSLNNSLNNISSSSSGGTGGGSGTTAAATGSSLSNSNSNSNLQNSQSANNSPIIHRRRTSSFSYDPNIHHSSLTHSNSNSNLISTNTSSIGNSAPSPTTLGSKPFSIPKLNLTENNLNNSSSTSSSPRNNGNEVIQSSSSTSSPRVNAPPPLEHKKSFLNIIGISPRGTNRERSSSTNSLNNSTSSLKSSNNNILQQQQQQQQHYDSAPTTPRNFGTFVRTQQLQNQQQQLQQQESIEAFDFEDDSTLGEVLNKICTRYQYIEKDLLEDYSLITKDGLWFVDRNKTITELGLKHMDEVEFKRMTQKVKVVFLNKEIVLNFNPSDTLKEINYKIIVHYLPSLIKLSRSNSILSSSSSSIFLNHQSSSSSNSSSSPSQSYRSSLSLEPLVISDLENSQILSNTPTITTVGNHQILNLQQQQNKQRSYSDASPLSFSKDYTSEISNHQQQNIENHINRRKNSISTNPLTNSGNIANNNNNNNNNKDKDDNNNNNNNNNNNNNNNNNNNNNNNNNNIASSTDTIQSNSSTGSLGSNNNIAFSIQQNRYPIPDNLVEFKDFKLHLSGTKNQNPNINQKFDMLLDERRTLSSFNFWNNIKLHFKNSSKSLHSDSKRVAPTLPFYLQIESVEQFSVSHILELEGTLLISDILKSFNRLLLNNENIKINDPLDEYGLFFNTVNNGNREGLSYGSSIYLDPYKTLSHYPMIEPLDKLMFKRTNTIFGVDPNTIVSKIDPITGFNIPCLLLDLKQKFIELDGFSIEGIFKTNNYYDLTFTEIIKEIENGTLLTSNNPNVDAIGIACFIKRWFSKLPKKICSLLDDETLLYASTQESTAEASLDSIPQPYRSLLLWLVRFLSEVSQSAYTNKCSAKILAIVIAPNLISISPNNNNNNKENNDHHHHHHHHHNSHHHRDNNNNNSNNNSSTTPTSSSVGKYTSLEKLHQCTLFLRNLIKLKLRENGFLPISTSSISISNSHNSSSFISMTGTSETSIHSSNSPISSSISRSPSLTDIVEE
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MFCAISGVSPLHPVVSIKSGYVYERSLIEKYLKENEGKDPITGDIVELSELVDVKTVPSAPAPPPRAPNLSSVPSLLVTLQNEWDANMLECYELRKQNASLRQELSHALYKEDASMRVLARVLKERDEAREALGSVQSSLGLSSALESKTNGNDTEMKDAAAPQGLPEAVLGRIDTTSKALMATRKKRQIPAGYASPAALKTYIQKTSIPSLHSTKPPGITCLKVTGLDDNLIVTGGMDKVVQIYDRTTEKVLATMKGSTKKINSIAVVGGQNATSKELPKMIIASYEKTIRFWVPSEKKVGYVAGGTIVQSDEVTGIDLHPSESLLLTGCGDGSWALHDLEHPSGTPKTILSVSLNDVPAGTSISSVKWHPDGVILAAGLSNSALKVFDVKTATCVADFEGHANVGGGPIKSMCFSENGYSLATTAQHSATIKLWDLRKLTNYHTITLPEGYEPTQVAWDYSAQFIGVVGNDLRIWQNKTWEELVVYDNNAAELTGLNFTKAGSEIVVGGMDRTVTILSAPVVANDSASS
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MRTFIAIDVNEEVKKQASEIIEKLMKRGFGATWVSEENMHLTLFFLGEVDEQKISEIAEHLCRRVRGFPSFSFTVKGFGYFKRKMSPRVFWLGVENTDRLMKLYEELRNELSHHGFSFEEKFVPHITIGRVKYYPDKWEKLIEDIDFPPIEVAVDRFKIYSSTLTPTGPIYKVLYECQFEGGLIRYA
The following text describes a protein:
Function:
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MAISATGMGSGLDISNIVKVLVDAEKAPKEAMFNKTEDSIKAKVSAMGTLKSALSTFQDAVKKLQTGDALNQRKISVSTDAYLSAKAEKTAQAGSYGIKVEQVATNHKIAGTNVADATQPVGEGSLAFGVNGKSFSVDIAATDSLAEIAKKVNEASDNVGVTATVITSDAGSRLVFSANKTGEDNQISLTATNTSGSGVTDMFGSGNTSTLQDAKNAVLYIDGQKVTSQSNEVKNAITGVTLNLTNADVAKTTTVKIEQDNEAVKTNVQAFVDAYNSLVTTIDKMSSYDKDKKTAAALQGDSMIRSIESQLRSVASGRVPTADGGSIALYDIGIKADRYGKLSVDDTKLNKALTEDMSSVEALFATPDKGLANRFNDLANSYVKSSGLIADRQSSYTTQQSRLADQRAAFTLKMDQLTARLTKQFNAMDLVVGKLNQQSSGLVDRLNSLPGAVKKS
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis.
Miscellaneous:
MISCELLANEOUS: Extracytoplasmic function sigma factors (ECF) are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning anti-sigma factor is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P), while cytoplasmic proteases finish degrading the regulatory protein, liberating SigD (Probable).
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core (By similarity).
Sequence:
MVDPGVSPGCVRFVTLEISPSMTMQGERLDAVVAEAVAGDRNALREVLETIRPIVVRYCRARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYGIAAHKVADAHRAAGRDRAYPAETLPERWSADAGPEQMAIEADSVTRMNELLEILPAKQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAAGDYA
The following text describes a protein:
Function:
In association with ufd-1 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. Regulates ubxn-3 nuclear localization during S phase.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the cytoplasm during mitosis. Nuclear localization upon nuclear membrane re-assembly is cdc-48-dependent.
Sequence:
MVIEVPQTERVNDVDVFLSTQDGQIQRPKGPNCRHPVRQKCTNCLPVDPFDEEYLKEKDIKHMSFHAHVRKLLGSQGKGTTLKKPLENFRCSLKPNCDAHKPFPKGICTKCKPQVVTLNRQKFRHVDNIQIENQELVNQFLDYWRLSGHQRVGFLIGQYQPHLEVPLGIKATVAAIYEPPQHCREDGIEFLEDKNQKTIDNLLEMLGLQRVGWIFTDCWTANSAEGTVHYTRHKDSFFLSAEECITAAMLQNQHPNITEYSMDRHYGSKFVTVVASGDESMHVNFHGYQVSNQCAAMVEADILCPTLYTPELAYVRETPLSEEHYITDVQFSMKNEYGAEVMKNGRPLPVEYLLVDVPAGMPKEPHYTFHVGTSNKSKSAKFNVENRQAIGQLQGGANLIQYSSEFSTNQFLEQATNFHFLLYLVTNDQVQISDEWMKRLCDAVKAQDRGTAMEWAQECEDWHQLMALAHANGGSGNDVSDIPVIPNGDPFSGSSSGGSRGAVWSCGHCTFQNEAGRQDCSMCGLPAAD
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MVRLLHISDIHLGSGLSHGRINPATGLHTRFEDFLYCLSQAIDRGLAEGVDLALFGGDAFPNATPEPTHQEEFARQFKRLTDAGIPTVLLVGNHDLHGRGVGGASLNIYAALQVPGFVVGSRLQIHPIATRSGPVQVLSLPWVNRSTLLTREEMRGKSLEQVDLALVERMKLALEAQVRRLDPAVPTVLLGHLMVENAVFGAERHLAVGRSFSIPLAMLARSEFDYVALGHVHRHQVLCEDPPIIYPGSIERVDFGEEKESKGFILAEVERGRCRYEFVSVPARSFKTIQANLADSGDPQGDLAAILRKHKIEGAIVRVLYRLHPHQIERIDTASLRQMLEGAFSYQLQPELISQLSQPRVPGLGESCALDPIDALRQYLESRPELADLRLALVEAAEALIKGDSPGLADTDECESDAEVLEVTTTAALDLLAREEGLPAGGTNGQLGLFHA
The following text describes a protein:
Function:
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSTAEQLFGAEEEEKYVDQDLSEDEEDERFLKAIRSSRSTKPVVDVLKVKSESSADELEERDAHLDRFRRDSTFESETSDHEDFSGGSENELDEETTKNANSIKKISLEEVEKQRKAIKRSGVIYLSRIPPYMAPNKLRQILSQYGKIGRVYLTPESSAKRAQRLRNGGNKRVMYEEGWIEFESKRVAKSVAELLNTNQIGGKKSSWYHDDIWNMKYLPKFKWHHLTEQIAAENAARESRLKVEIEQGRKQLKQYMRNVENAKMIEGIRKKRSERDTLNVSTEFPEETKDLSEDTKPSKQARRFFGQKSIVSNRNMPTDNAKQQKVENVLRRVF
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Sequence:
MDQVSRSLPPPFLSRDLHLHPHHQFQHQQQHNHGHDIDQHRIGGLKRDRDTEIDPNEHSSAGKDQNTQGSGGESGGGGGGGGGGGDNHITRRPRGRPAGSKNKPKPPVIITRDSANALKSHVMEVANGCDVMESVTVFARRRQRGICVLSGNGAVTNVTIRQPASVPGGGSSVVNLHGRFEILSLSGSFLPPPAPPAASGLTIYLAGGQGQVVGGSVVGPLMASGPVVIMAASFGNAAYERLPLEEDDQDEQQTAGAVANNMDGNATMGGGTQTQPQQLMQDPTSFIQGLPPSLMNSQLPAEAYWGTPRPSF
The following text describes a protein:
Function:
[Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3; [NT-proBNP]: May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32; [BNP(3-32)]: May have a role in cardio-renal homeostasis. Able to promote the production of cGMP.
Miscellaneous:
MISCELLANEOUS: Plasma levels of natriuretic peptides B, brain natriuretic peptide 32 and NT-proBNP are widely used for screening and diagnosis of heart failure (HF), as these markers are typically higher in patients with severe HF.
Subcellular Localization:
[NT-proBNP]: Secreted. Note=Detected in blood; [proBNP(3-108)]: Secreted. Note=Detected in blood; [Brain natriuretic peptide 32]: Secreted. Note=Detected in blood; [BNP(3-32)]: Secreted. Note=Detected in blood.
Sequence:
MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH
The following text describes a protein:
Function:
Plays a role in development of both male and female reproductive tissues.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site; MISCELLANEOUS: [Isoform 3]: May be due to a competing donor splice site.
Subcellular Localization:
Nucleus.
Domain:
The cysteine-rich domain CRC binds zinc in vitro.
Sequence:
MGEGEEGDKFPPKTDEVTQESMKSARQLDFTGGSSDVEHSHSNQASSMAAASIPSPIVTVTRPIITSQAPPTVATPIPPPPQSQGIILHVPIRHPRPESPNSMPRPAGETRDGTPQKKKQCNCKHSRCLKLYCECFASGTYCDGCNCVNCFNNVENEPARRQAVESTLERNPNAFRPKIAASPHGGRDNREEVGDVVMLARHNKGCHCKKSGCLKKYCECFQANILCSENCKCLDCKNFEGSEVRQSLFHGEHSHNLAYLQHANAAITGAIGSSGFASAPPPKRRKGQEIFFNQGTKDSSTHRLGQANNGRTTSSQTGSRAGGNASLGPSKVVYKSLLANIIKPMDVKALCSVLVAVAGEAAKTLTEKRLANQKETSVASSVQDQGHVNNKAEKSGLEDSNADGSKGRSLSPETLALMCDERDTMLMVAASPNCSVEPTSQLPNGQDQVYAEQEKVVLTKFRDCLNRIISCGEVKESNCSMSRMDLDTPVQTTVRIDPVVQQAPVANGVSQTAKQPSQLNTTTPNTSSQTANGVSQTAKQPSQLTTTTTTPNTSSQTHLHKTPALSEKKDL
The following text describes a protein:
Function:
A probably minor shell protein component of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. This subunit probably does not form homohexamers.
Subcellular Localization:
Carboxysome. Note=This cyanobacterium makes beta-type carboxysomes.
Sequence:
MPQAVGVIQTLGFPSVLAAADAMLKGGRVTLVYYDLAERGNFVVAIRGPVSEVNLSMKMGLAAVNESVMGGEIVSHYIVPNPPENVLAVLPVEYTEKVARFRT
The following text describes a protein:
Function:
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNDAALPPDVSAALANGLQAQSLDADFAAPLLRYLTLLVRWNKTYNLTAVRDPREMVTRHLLDSLAMQPYIVSGTLADLGTGPGLPGIPLAITRPQLQVTLVESNGKKARFMREALRHLALGNARVAEARAEAVDEPAAYDHLTARALDTLAGIIAVGGHLLRPGGSLLAMKGVYPHEEIAALPAGWRVGEVHPLQVPGLDGERHLVVVHKD
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTSDSDHTHAAVKQRQQRQPRQQRNRSRSSISADPEEFLPSRPPSPPGPSANAPPPSERVTHLRLSAHYAVLVLASMLGCVARIGLNGLCTYDGQIIYALAWSQGIGSGVMGLALAKKNEMTILYPPLYTFLTTGIAGCITTFSSWMLEGYLSFSNFNHYNRKGLHDTVDGVAYSLSTFAIALSCLRFGEHFGSALPKLPYFNTLSRVTPPEEKSSSPSLLPHTPILDILTILTAFLAYLIALLLYFLAPHSWRHDVVFPLLMSPPGAILRFSLSNINIRHPFINRFPLGTFISNMVATLLIAGTFAAQRRPNVVNAGSVRCNALYAIQQGFCGCLSTVSTFVVEARAVEGWRWKWLYVGASVILGHVFVLAVVGGTGWNEGYVDACTG
The following text describes a protein:
Function:
Transcription factor that activates stress response genes via SLE (STRE-like) elements. Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress. Activates a subset of the genes that are repressed by NRG1.
Subcellular Localization:
Nucleus.
Sequence:
MDSHNNIDQSVSELLSDPASVQQSYNSQLRGPEFDQQRQIRNQVSPFNKMTDTIDNDNIPLSSDYDKLYQQFSIPSQQQYENNSDNVYKTNNDLAALASPLNMDLDLAPSDQQQQPQQSQQQFLNDFSNLQPHLNNSQEQVQLNGLTSNILSNPQITVNMPGAYHQNYNCDQMEIDDSPPFTIESDLYFEQQTDNNSIVTSNRVHNQPDVESMFNNQLSVPSLQRTELSPQQHETNVTTGRPQESAFGSFDNNSRVSSFANVNNAGTNLFVNGKDLYFDDESHHRTGRLRNGSIDSYYAANVINHQLHLQQQTQAQAQAHQQQQQQSQQQHSPQDLASHTSLPSKSIYNELSPLTTTTSRASSIQSGQPSFFSAQQYFSRNSMDQVPSSLHRPSFDLYNHRPSIDSQHSQQSQQRNARYTSFTSSISNILPFMSEKNTNHNNRSPPTPPTSTSSPQNLLSSNQSRHLIRSIFKTNPTPIVSDAGNSNGNIVNGGSGTIDAENLPDAPYASGTINDSEFLILSSPTKEEPEDELMQPKKVKKPKRSLFTRFKTPVKQEQPDSEMAVSAPVDELKPDETVIDMVGNISSHHSSGTPSITTGAGGNTLEHSISESSFQEPDYAALFENVGKRKNKSYRKPKGKTKEEEQQQQQLPLSSGTAGGTSSNNSTGTVEKTLFFNKTKIKKEPASERSSLLDNASAGNASASSSEASSIQNAIGSDDHNGPPLTSAPTSSTLANASKRILSSKLISKKKSTSKLKEYTAAELEDMCTVSSLETPVATMISKGIEVEVDLASLDLPPDTKIFPTSIINNKNRTRGRKENKEADLSDTSKIYLCNLCQRRFKRHEHLKRHFRSLHTFEKPYNCDICHKKFSRSDNLNQHLKIHKQEDEKDCADAETGVGMDDASG
The following text describes a protein:
Function:
Probably involved in membrane trafficking.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.
Sequence:
MNRREDPNPFDEEVNPFSNGDAAAPGSKSRVPQMVASSLGFGQKHDATVDIPLDSMNDPKKKERELSNWEADLKRKEKAFENSFKLLISMLQDIKRREEVVAGAAIPTDDRNWPPFFPIIHHDIANEIPVHAQKLQYLAFASWLGLVLCLVFNMIAVIVCWIKGGGVKIFFLAVIYALLGVPLSYVLWYRPLYRAMRTDSALKFSWFFLFYLIHLGFCIFAAIAPPIVFEGRSLTGILAAIDVFSDHALVGIFYLVGFGLFCVESLLSFWVLQVRYSF
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MTTSHRPQLEARSGTKSGVAGEYVPTGVKHARLLPGHRTVKRRREGGATAEDEERERAGAETRTVDCNEGTDELAGEGRSAGSGDGDEASSAEDSSDADDEDDVDNPEELRRELEALRASKTGAKTGAKTGAKTGEKGAGGGGWRAGAVFGRQKRRREQAEGRAYRNDVTQSEYHQDFLRRLTK
The following text describes a protein:
Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVRIDGSYGEGGGQILRTSIALSALLGRPVEIVNIRAKRANPGLQPQHLTGVKVAALLTDAEVKGAEKGSTRLYFEPKTLKCGNFSIDIGTAGSISLIVQTLAPILLYAPCPTQITVTGGTDVAWAPPIDYMRFVFTKVLERFGAKLSIELIRRGHYPRGGGRAVVRAEPVKRLKAVESEEFGNVVKISGISHAVNLPPHVAERQAKAAREELSKMGLDADIAIEVRNDGLGPGSGVVIWAVSDAGNVIGGDSLGERGKPAETVGKEAAQKLIAVLKTRASVDPHMADMAVLYMALAEGRSRISTSEETMHLKTNMYIIEQFLRVKFSTMEKAGRYTIEVEGVGYNR
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSNPRKAPEKSNFVQRCNLLSRYFKEKGSFGDLGLGMGRQLKSKETPPETSPPAATTLDLLKNMENSTDQALRQNGAVAPSNAQPKVFFPQLGCFGPQNSIDIAANRTDLSTKPEIKEPEALLTKQKQPEATAQMTKQKEPEATAQMTIFYAGEVHVLNDFPADKAREIVALANKGCSSISRGSTFTSGVKNLRSSGCSMAPESSSVAMHKKNTTQERRLQATGSDLPIARRASLHRFLDKRKDRAAAKAPYQVEPPSEASPDSEQRNPWFGHEDQSSKHLDLNL
The following text describes a protein:
Function:
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases.
Subcellular Localization:
Mitochondrion.
Sequence:
MPRPTRKFRRLVALRGRYSRCPKPRPLSPCLPNPDCFLGWGRGHGVRRSLVEAVPGPALTKLRHFRRVRPASVRCTMAALKSWLSRSVTSLFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTVGFGVTLCAVPIAQKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARAEMSSKHQEYLKLETTWMTAVGLSEMAAEAAYQTDGENETWNHSQWQNQDKLFVYVRLCGADQASITARNHIQLVKLQVDEVHQLSRKAETKLAEAQIEELRQKTQEEGEDRAELEQEAYLRED
The following text describes a protein:
Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLNDSCHNKSHIDPSHTPVPSAIMFAAGIFGNGLALVILELRRRRQAKKDGQKHSALFHILITALVVTDLTGTCLASPIVLVAYAYNTTLILLSSTTYHNLTLNQTVTVSKPIVCQYFGFTMTFFSLVTLSLLFTTALDRCFAIGYPYLYSRHVTKKWAYIIIPLLFVFSTLFCLLPFFKFGLYVQYCPGTWCFIDMNPKEPEHRAYANLYATVMLVLVLTIVVCNGFVVKQLFMMYQRRKRQGSIVTLAKRSNSHRKLVSMAEEVEHLILIFIMTIIFIICTLPLVIRVYMNSIFREKESHILDLTALRFISINSIIDPWVFILLSPSVVHFFLFSVCHAPFGSSRDSVCKASLVRETELTSARRPGEDFTSRENI
The following text describes a protein:
Function:
Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression.
Sequence:
MRSKLPPLNALRVFEVAARAGSYSAAARELNLTHGAVSRHITILEDWLGQPLFVRDGQSMVASGHARAFAREVSAAFDHIADAAERYGKSRHRKVIRVSAAATVAMRWLIPRLPLFTAICPDVDVRVSTTLTTDSALRGSFDLAIRREVPADGQYQAWPLFEERNTVIASPALIEQTAISSVEQLAAETWLTTESRPSDWERWTQAVGQPTLRASRTLRFDHFFVTLQAVVDGLGFGIGPFPTLDADCTAGRLQKPFPDLTSKGATYFALVPLDADKPVHMRAFVDWLRSSGEDDQSSKKK
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MQNLVVASSGAGAGASGGPSRNTVGPMDHDNLKLRQYMQNFVFNIVLQRQQSPVDAASKAKFMEIARRLEEGLYKMANSKEDYVNRSTLESRIMGLMKSRYMSNYNQLLADSSSVGAMIPTPGLSHAAGNPSSVVTSSADATVAGNNNSTSTAVNTGNLLAAGGMHEGNVSTGYQRSSRNFSLGSGGNLASLGCQRSTAQMIPTPGFANNGTNNNSDGFSGVANNSVKDGVGVNEKSVDTGEGYRATNPDTFGLGIRQIQQMLRPQNIGSDPKNSFRNLAVGVELEPSPRGQWPSQSQENTQISNGMSSEQKVQEDFRRRSTGIDEAQPNNLTEGSVIDQNHTSTISESHSLQNSIAYQQRWLLFLLHARSCKPPVGKCTERNCVTVQKLWSHMDSCVKPRCLYSRCGITKSLIIHFKTCKDIRCRLCVPVRRTYNQQQANARLQARLQNKSSAVIAVNRDVVSNDSLCATAGAVSSAPGCADTLDNLQASSKRLKVEPSFQPVVSETESCKSSIVSKTETELSQDAERKDHRHSDAHAVLKPENVEVIEEISDISVQAGFGIKEKKHEAFENDPKPRSVSEPGQHDLCGASPKQENIKMEQETKKEVLVESADVVASKSGNPKIKGVSLTEFFTPEQVREHIRGLRQWIGQNKVNAEKNQAMENSMNENSCQLCAVEKLTFEPPPIYCTPCGARIKRNAMYYTVVSGEHRHYFCIPCYNGSRGDTILAEGTSMPKARLEKKTNDEETEEWWVQCDKCEAWQHQICALFNGRRNDGGQAEYTCPNCYILEVEHNERKPLLQSAVLGAKDLPKTILSDHIEQRLFQRLEQERTERARAQGKICDEIPTAESLVVRVVLSVDKKLEVKSRFLEIFREDNFPTEFPYKSKVVLLFQKIEGVEVCLFGMYVQEFGSECSSPNHRRVPAIKCAYGEALRTFVYQEILIGYLDYCKMRGFTSCYIWACPPLKGDDYILYCHPEIQKTPKSDKLRGWYLAMLRKAAKEGIVVGTTNLYDHFFLQIGECRAKVTAARLPYFDGDYWPGAAEDIIQQMGQEDDGRKGNKKGILKKPITKRALKGSGQSDLSRNMSIDQLLMHKLGETIRPMKEDFIMVHLQPCCTHCCTLMVTGNRWVCSQCKDFQLCDGCYEAELKRWGKERHPVNQKNQHTLYHVEITDIPADTTDRDAILESEFFDTRQAFLSLCQGNHYQYDTLRRAKHSSMMVIYHLHNPTAPAFVATCNACHLDIESGQGWRCEVCPDYDVCNACYSRESCVNHPHKLTNHPSLADQNAQNKEARQLRVLQFTIMRDLLVHAIQCRLAKDCQYPNCRYVNRLFQHAVHCKIHVGGGCDRCKKMVHLLQSHARACNESNCDVVRCGELRERLRRIQQRSESRRRAAVMEMVRQRAAEVAGTSG
The following text describes a protein:
Function:
Probable chaperone.
Subcellular Localization:
Membrane; Single-pass membrane protein. Mitochondrion membrane.
Sequence:
MKQKLPQPFYGPLRSTHPSYTRPHPPSGPSSPYASSSSSSSTSSFQFPSSRSPSPFEIFHLPRSASTSQIKERYYQLVKLYHPDVAGSKSNGASSLQEEEITRRFKLIRDAYELLSSPSRRQRYINFHEGWHDSRAQTPNRSWRNNHTRGYRHPDPDFNLSSVWTQFINRHRSARAGFYSSVNDDGSTNGFNTHHHQQDSPGGSYTFKQQWDRDGLFTKNGVFISAVGCISLCLYLVQLWRVLPLVGSPDHPLQPSSSSSSSEKEKHKFRAFIEPAGDARLDQEAWAKLRAIQFTPIDPHRPLIPSQHSQSPSPSPPALLDHHQNPEPNHRFYSSSFQDRIQKQNLKALSDLKSARASAVKPSVFSNRISADSAHSPPPTPATSS
The following text describes a protein:
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Sequence:
MFKAVLIIPDSYKRSNVKELVDMMMNKMGFSQMFVVQESVCCSFGDGSQTCCVVDVGHCKTSVCCIEDGLIKKNTLFTARLGGSDVTKCYLWLLNKYGLTNKNVNLVENSRRCSLFIQHLKERYCHLMDVNIFDCFVLNENLINYKRQLNLSAMFKFHMSDERMLTPLCLFFPDMLGLKATPGIHKSMIFGVEKSVSDASDYLDDEYIQQTTTKHEQAARLRKKEVYENHTNTLLQDAICPDETMASNDYEALDQPDSALKGNKNDDDIDWLNVYESTLVGLHQLAIKSIDSCESEDTKQKMFSNILLTGGGSKFMGIHLYFEYLLSCHMQSIKNRNVYDINIKIKDDDQGIRGACIMSCLDTVQELWFDKYQWCKYSVRILREKCPFVW
The following text describes a protein:
Function:
Required for high-affinity, high-specificity GABA transport. Also transports putrescine.
Miscellaneous:
MISCELLANEOUS: It requires NPR (nitrogen permease reactivator protein) for its full activity.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSMSSKNENKISVEQRISTDIGQAYQLQGLGSNLRSIRSKTGAGEVNYIDAAKSVNDNQLLAEIGYKQELKRQFSTLQVFGIAFSIMGLLPSIASVMGGGLGGGPATLVWGWFVAAFFILLVGITMAEHASSIPTAGGLYYWTYYYAPEGYKEIISFIIGCSNSLALAAGVCSIDYGLAEEIAAAVTLTKDGNFEVTSGKLYGIFAGAVVVMCICTCVASGAIARLQTLSIFANLFIIVLLFIALPIGTKHRMGGFNDGDFIFGKYENLSDWNNGWQFCLAGFMPAVWTIGSFDSCVHQSEEAKDAKKSVPIGIISSIAVCWILGWLIIICLMACINPDIDSVLDSKYGFALAQIIYDSLGKKWAIAFMSLIAFCQFLMGASITTAVSRQVWAFSRDNGLPLSKYIKRVDSKYSVPFFAILAACVGSLILGLLCLIDDAATDALFSLAVAGNNLAWSTPTVFRLTSGRDLFRPGPFYLGKIWSPIVAWTGVAFQLFIIILVMFPSQQHGITKSTMNYACVIGPGIWILAGIYYKVYKKKYYHGPATNLSDDDYTEAVGADVIDTIMSKQEP