lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MAAPKGSLWVRAQLGLPPLLLLTMALARGSGTASAEAFDSVLGDTASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGTDLNRTKSECESACTEAYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIFQPEIQYAPQLEQEPTNLKDSSLSKMSYLQMRSSQAHRDYVEDGESDGFLRCLSLNSGWILTMTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPAASLVVVRSKAEDHEEAGPLPTKVNLAHSEI
The following text describes a protein:
Function:
Catalyzes the transfer of the malonyl group from malonyl-CoA to the 4'''-hydroxyl group of the 5-glucosyl moiety of anthocyanins. Anthocyanins are ubiquitous colored pigments that are responsible for petal color.
Sequence:
MNINQINTKLIKPITPTPQNLKNYHISFLDQHVVKKYIAVVLYYQSAPDNGRLEDSLAETLVHFYPLAGRYIKTDLTVDCSDQGAEFIEAEARGDVRVTDLIGKTDTIHLCPEQYFGLDEGVDDPLLSIQVTRFSCGGATIAVSVSHRVFDVSSLETFLSAWSSASKTGGGVAPVIPSFALASLLPNKDEKFGLDSNKCQGKEQKIAVKRLLFEKRALTRLTSERTSGVRAACAVIAKALIRLDRTTHGKSRDFVVFQPINMRGRTGVPSPKNACGNMSFGSFTRRVSAKEEVGIGELVGLIGDGVRRGIAEYTEILCPDRDGRDVIIHVRNKNIKEVFKSETFVVSFTDWSKFGFYEVDFGWGRPIWSGVGPQRPRGNQTIMMRSKEGDGIEAWVHLNEDDMDLFEQDVEIKLFLS
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.
Sequence:
MWQLIEDGPWSRWQCNLLCDWPHGFFTRHARGAPPGELASALGLEPHRAYRLKQIHSALVHPTPVEPDASGDALWTGRAGESVWVGSADCTPILLADPVSGTVAAIHAGWRGTAQAILPFTIEQLRQAGADPADLLCAMGPAISGRAYQVSEPVAFEVTGTVKQAELALLPDAELGKVRLDVREVNRQQALQSGLRAERIAICPACTFSSPDWLHSYRREGGGKIQFSGIGPGLAV
The following text describes a protein:
Function:
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP).
Miscellaneous:
MISCELLANEOUS: The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO(2), O(2) and reduced vitamin K are cosubstrates.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAVSARPARAPRGSDKVKKDKAAQTSGPRQGSRMGKLLGFEWTDVSSWERLVTLLNRPTDPAGLAVFRFLFGLMMVLDIPQERGLSSLDRRYLDGLEVCRFPLLDALQPLPLDWMYLIYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFVDAHHYWSVDGLLRARKRNAHVPLWNYAVLRGQIFIVYFIAGIKKLDADWVEGYSMEYLSRHWLFSPFKLVLSEEMTSLLVVHWCGLLLDLSAGFLLFFDASRPIGFVFVSYFHCMNSQLFSIGMFPYVMLASSPLFCSPEWPRKLVAHCPKKLQELLPLRTAPQPSTSCMYKRSRARGSQKPGLRHKLSTAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTPWLQPLLMDLSPWRTKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLQEGEKMQLPAGEYHKVYTVSSSPSCYMYIYVNTTEVALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNAPFHERLVRFLLRKLFIFRRSFLMTCISLRNLAFGRPSLEQLAQEVTYANLRPFEPAGEPSPVNTDSSNPNPPEPDSHPVHSEF
The following text describes a protein:
Function:
Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells. When overexpressed in M.tuberculosis or M.smegmatis increases resistance to hen egg white lysozyme. M.smegmatis overexpressing LprI survive better during intracellular infection of peritoneal and monocyte-derived macrophages, both of which produce lysozyme during infection; M.smegmatis does not encode this protein. Somewhat better survival is seen in human cell lines when M.smegmatis cells express both proteins from this operon, i.e. GlbN (HbN) and LprI.
Subcellular Localization:
Cell membrane; Lipid-anchor. Secreted, cell wall. Cell surface. Note=Protein is accessible to externally added trypsin and alpha-D-mannosidase.
Sequence:
MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQLVCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEAYQTRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFVELSGSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLYELIAIVRPGSLNEVRDIARNAGTLVLRSGGVIRGYTNWGVFRLPKTTTKHQARYTDGHHFIMRFDAAAPVQMGIRRQLALDPRMIRFSVVKLGDKLDEVKDVTGKVEWNDTRNLSSTI
The following text describes a protein:
Function:
Molecular scaffold for [Fe-S] cluster assembly of chloroplastic iron-sulfur proteins.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MQTTTVPMAAAAAVAPSTTTSSSASFKVAAYAWSSCRSSSSPATRLVAAPNHQRPPLVVGAIAGLDPVTAVQLPLTAGNVESVLDQVRPYLTADGGDVALHEIAGNVVRLKLQGACGSCPSSLITIKRGIERRLMEKIPDVAAVEPVTDKETGLELNEENVEKVLNEIRPYLAGTGGGGLQFLMIKGPIVKVRLTGPAAVVRTVRIAVSKKLREKIPSIQIVQLLS
The following text describes a protein:
Function:
Serine protease involved in intramembrane proteolysis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSNTGFNPKNAEKKRSSIFSDLEIPQGDVKKKASIFNNMEKKKMTIFKKTKGENNEEKKKRSIFNNNNNNNNNNNTMKINIFNNNNEKKESFSINGDEKKKSFSINGDEKKESFSINGDEKKESFLINKDEKKESFLINKDEKEKSFSINGDEKKESFSINGDEKKESFSINEDETKKSCSINDDERKISIFSNNEKKKNSIYSDTQSSKREDEKRISIFSDLETSTNIDDISSKRNSQKLSVYGDNKLKKGSLLSPKVDNYRNTIDNINEINDIKIIVTSDENLHTLPSGAVGRRAPLNPFSSPILGKYRRKNKNAKAKVKDPRLNNNPLIGRLTVCISTTAILFWVFFAEMVFNYNTFNGRCISKVLYPIYTENVVLKRQPFFVFLGYGACEYNLDESASNRHFIGSKASDEGWPGDKVEENPDGRGYANWDSVNNRVYNLLGGLNTNYIRNYGELYRLFWSMYLHGGFMHILFNVICQIQILWMIEPDWGSIRTGLLFFISGVTGNLLSAVCDPCGVTIGSSGSLYGLIGALFAYYIEYWKTIPRPCCVLIFMFLVVMFGIIVGMFGYTDNYAHIGGCLGGVLFGFSTITTVSAADKCTLGERMLVSAPFSWFLSNETKELIIAKAKDKKIKGENFRKKQLANKVHKNDALHVAMAVMKNRINDEGRPPCRMKLREWIVRITAASTLIIMWIVLFIYLLNEKAYKSYSPLGQIKFSGVHSCYCCQIVKNKFTYIKVNDFYWCFTTEEATRYYCNK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MNESKPGDSQNLACVFCRKNDDCPNKYGEKKTKEKWNLTVHYYCLLMSSGIWQRGKEEEGVYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNFASFCWDHRPVQIITSNNYRESLPCTICLEFIEPIPSYNVLRSPCCKNAWFHRDCLQVQAINAGVFFFRCTICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEIKRCHCCGSSGTHLACSSLRSWEQNWECLECRGIIYNSGEFQKAKKHVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKDLLRQGSKFRRNVSTLLIELGFQIKKKTKRLYINKANIWNSALDAFRNRNFNPSYAIEVAYVIENDNFGSEHPGSKQEFLSLLMQHLENSSLFEGSLSKNLSLNSQALKENLYYEAGKMLAISLVHGGPSPGFFSKTLFNCLVYGPENTQPILDDVSDFDVAQIIIRINTATTVADLKSIINECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRVHTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSELFTVHTLPDVKALGFWNSYLQAVEDGKSTTTMEDILIFATGCSSIPPAGFKPTPSIECLHVDFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLEKEESSHYIGH
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MAKSKIVKAAGAISLATTFSRILGYIKDMILAKYFGATGISDVFFVAFRIPNLLRELFAEGSMSSAVIPVLKESQIKNGQEETQKIVKSLFTFIMIVVGIITILGIIFSPLIVKLIAPGFVENPQKFDLTVLLTRIMFPFLLFISLAALTMGTLNTNNIFFIPALAPCFLNIAIIIFIVGFSSLFFNPIISVAVGVTVGGALQWLVQTPTFYKNGFKFGIAPFHSALKKIAILVIPTTIAMAVNQINIFVSTIIASFLPEGSVTYLYYSMRLIQLPIGIFGVAVGMAVLPTLSQHVAEGKKDIFTKDFTFSLKFLFFLTIPSTLGLMMLKEPIINTLFQRGVFDITATINTAQALLFYSIGIIGTVGSRTITATFYSIQDTKTPVICAATAMLTNVIVSIALMNSMQHKGLALAYSVAATVQFFMLGYFIKRKIPQISFNSIISSFLKSFVAAFISVSIAKLICEINPSLWLHSEKMFLKFIWLACAISVAAFFYLVLCYLLKHEELGYILKKIRRQG
The following text describes a protein:
Function:
Probable component of transcriptional regulatory complex with SMAD protein daf-3. Required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions. Involved in larvae undergoing cell-cycle arrest during the dauer stage.
Subcellular Localization:
Nucleus.
Sequence:
MSDSPIGSSQQVEPEHRTPDLMDIDPLIANLKALHEETRSDDDDDGQPSTSAKRKDSRADGIVIHQKKYSDPGRFLWIWLLGVRVPALSIDGEPHLPIEILDDMLTKKDKKDQMSFQNLLRYKNVYIRMASPSQFRAVMEKSKECENLNITSLSLMSRSDIERIMGELRLESMLTLAEHDNWDISDRVHVVHVNFIDYCSEWLESDDLEEDVMQSGTHGYWYKNRRNMRCIECQHCEGKFTPTDFIMHHHYPIKPSGFVHTGCNSFQWIRLIEVFDKSNENLEAWNKFVLNSHRAGKREYDEAAPHQAPPKRPAMETPVPVAADNGWEADEEEEGEEIVDRDADIEKCKLRNKKKMENLHIADFLGPSGSKGLKPRNKFEAVIIEQLNKMDDAALEALFLKSPEEYNLWVKESDFTHKVVTQQQEWKAKMKDPNFKSRASANFDVSKGEFDNMRHFDNASKATRQEIQQLAEQFANLDRDAKLLTPMEFVLREHALLKNVSADAIRVLCNRPPLPPLPPPPPPPKPKPAPVQPISLGNINFVALAQQLIASGIKLPLPIVTPPVVSTPAPVITPIPAALPISPNSDFLKQQLSTAMSSPALLSLYPKLTAGAYEQLAQFIKTTTVKN
The following text describes a protein:
Function:
In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MAFRELVDGNCGGRNPMLKVASHFTRDQGFRQDVPVSHRHPDTRPEDVMVREFLEGIPPPSQVGSRGAFNMDSLLREMRDLEKPQGIARPPIQPGPNVAHYAFDDKNWAEDFLRKEPHVIPEDLPSASGWSQEFLDSPGYMGVVDDYAEWDNHWDSLTSHIEKPGFSAPGALAQTAGEIIDRMKDPKFAQSEFLQFMHKVNQGEEDLTSEPRTTTAHSNSNWAEEFSGSEGVTRQPESSADQDWAAEFTTNRQPDLADEWTKEFNDGASAEVFRGGNPAQDDFWSQLQQDWEKAADDNPASYGWLKETQQDPLSEYTFVAENPYQDNADPYNTGLQKRLEGDLPSAILLFEAALKKDPEHVKAWEVLGLTLAENEQDPGAITAYKRCLALEPTNLVAMMGLAVSYTNESYQLQACQALEDWLRNNPKYGHLTSPSSARVNERERTFTSLVSGDTFNRVQDMYLTAARLQPSQDLDPDVQTGLGVLLNLSGDFDKAPDCFRAALQMKPNDSLLWNRLGATLANGGKSEEAIESYYKALELSPGFIRARYNLAVSCINLGAHREAAEHLVSALLLQARRSKRVMSDNIWSTLRMVLNLMNRREFIADIDAKDLTRLAAEFGIAE
The following text describes a protein:
Function:
[CLE42p]: Extracellular signal peptide that regulates cell fate. Represses tracheary element differentiation but promotes the formation of procambial cells.
Subcellular Localization:
[CLE42p]: Secreted, extracellular space.
Sequence:
MRSPHITISLVFLFFLFLIIQTHQRTIDQTHQIGSNVQHVSDMAVTSPEGKRRERFRVRRPMTTWLKGKMIGANEHGVPSGPNPISNR
The following text describes a protein:
Function:
May be involved in lipid metabolism.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPIPIIAHIAQFKYEHLITHWAQYTKAAIAVSTIAAFKFWTSGRTTTWERKMNGMVVMVTGGSSGIGQVVVEKLASLGAQVVILLRTEPDQFTVDYIMDLRKRTKNQLIYTEVCDLSSMLSVRKFATKWIDCTPIRRLDMIVLCSGVLLPPFMDRQTTEEGVELQWATNFLGPYQLLRILRPVIYGQPGHREVRIVAATCSSYILGNIDFNDLDLSNHPYPRKSPWKVVGNAKLALMTYLYDFQKKAEAHERPDKMPCNLHTIMANPGVVRTPGFRRVVSFGKVWGLFLYLLLWPFWWLLLKGTIHGAQSFFHAICSPEFASITQPVLVNECSIVEYSRKEITDPEFAEKLIKAADAQIDEVEKQYKKKKIKKSKK
The following text describes a protein:
Function:
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
Sequence:
MTALNHWQPSADIKNHLKRAKIIAKIRQFFTERGLLEVETPVLSEFGVTDLHLSTFSTEFLAPFGEQSKTLWLSTSPEYHMKRLLAAGSGPIFQISKVFRNEEAGNRHNPEFTMLEWYRPHFHMHRLINEVDDLLQQILDCPPAESLSYQFVFQEYVGLDPLSAERSELIEAARKHNFMAEDNEDRDTLLQFLFSEVVEPQIGKERPIAVYHFPSTQAALAQVSPEDQRVAERFEFYYKGLELANGFHELADAQEQRHRFELDNQQRQKCELPTREIDERFLAALEAGMPDASGVALGIDRLMMIALDCEKINDVISFAVDNA
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MADDASRKRKRPRRKSRKSKQSPSPQGHYADPLSPIASTPMKRHTKAAENNKSAKAKRAPLSDARDTNEPKSKEEEKFFSPRKLLKEYDQEEKPRAKKARTRLNYDSAASSEGDEEEKQQQEEDAAASADASASEDANDELFSPTLKPPKVSRSTSASPPNGRVRLESKFATASEQLDEKMEEETVEETGHAVVTEEAGGQEEEDATPPEQEFNPFYFMKTLPKYEDVVEGKRPISLPERSRNAPKICLVLDLDETLVHCSVDEVKDAHMQFPVTFNGVEYTVNVKKRPHMEYFLKRVSKLFEIVVFTASHKVYAEKLMNMLDPHRNLIKYRLYRDDCLDVFGNYLKDLSVLGRDLSKVVLVDNSPHAFGYQVNNGIPIETWYDDEADAELLNLLPFLESLVDVDDVRPIVEKQFQIQKLIDATPDEIV
The following text describes a protein:
Function:
Has glycerol-3-phosphate dehydrogenase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPLWGGRGVRTWAGAKGRSLPAPSAGKPKRKSGPGLCPIPVPHLSLSFPPLSLALPDSVSLGARLPSPGGRGLAAPTCVGVIYSQPAGELGRVAPSWRLRQRSSTMTGKKVCIVGSGNWGSAIAKIVGGNAAQLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAADADILIFVVPHQFIGKICDQLKGHLKADTIGVSLIKGVDEGPKGLKLISEVIGERLGIPMSVLMGANIANEVADEKFCETTIGSKNQAHGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGSVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGMVDKFPLFTAVYKVCYENQPVGEFIHCLQNHPEHV
The following text describes a protein:
Function:
Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTGQGQSASGLSAWSSTIFRHVRYENLVAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYKGILHCLTTIWKLDGLRGLYQGVTPNVWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLISAAEAGAMTLCITNPLWVTKTRLMLQYDSVVNASQRQYKGMFDTLVKIYKYEGVRGLYKGFIPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVIRARLQDQHMFYNGVLDVMTKTWRKEGISGFYKGIAPNLIRVTPACCITFVVYENVSHFLLGLRKDDIN
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Miscellaneous:
MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MNSEQLLHNYVSDSLLTTLISFQEFKQQLQSYTSDEQQLQHWYELLQARDARVTSELEARIKQFFITLRSRLLRFLESEQLSHSLSLETLIDALYKINDLLQQRLQILDDAIQEKTSELAEFENMVRSPSAGDNAIPGLLQIIQSYINLLEEN
The following text describes a protein:
Function:
Involved in the incorporation of salicylate into the virulence-conferring salicylate-based siderophore mycobactin. Catalyzes the initial conversion of chorismate to yield the intermediate isochorismate (isochorismate synthase activity), and the subsequent elimination of the enolpyruvyl side chain in a lyase reaction to give salicylate (isochorismate pyruvate-lyase activity). In the absence of magnesium, MbtI displays a chorismate mutase activity and converts chorismate to prephenate.
Sequence:
MSELSVATGAVSTASSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ
The following text describes a protein:
Function:
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis.
Subcellular Localization:
Nucleus. Nucleus speckle. Chromosome. Cytoplasm. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SETD1B each bind to a unique set of target genes (By similarity). Predominantly nuclear (By similarity).
Sequence:
MENSHPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNVRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAISPIVSETLQLSDALKRLKDGSLSAGCGSGSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPITPRLGTPFSQDSSYSSRQPTPSYLFSQDPTATFKARRHESKFTDAYNRRHEHHYVHNSAVAGATAPFRGSSDLSFGTVGSSGTPFKAQSQDATTFAHTPPPAQTATASGFKSAFSPYQTPAPPFPPPPEEPTATAAFGSRDSGEFRRAPAPPPLPPAEPPAKEKPGTPPGPPPPDSNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFLREQDSDTEIQMEGSPISSSSSQLSPLSHFGTNSQPGFRGPSPPSSRPSSTGLEDISPTPLPDSDEDEDLGLGLGPRPPPEPGPPDPMGLLGQTAEVDLDLAGDRTPTSERMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVAAPNVLAPNLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQMLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRSPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYIPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDIADAPCELTKRDPKSVGVRRRPGRPLELDSGGEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEDRESTEEEEEEEEEEAEEEEEEGPRSRISSPSSSSSSDKDDEDDNEADSDGQIDSDIDDQGAPLSEASEKDNGDSEEEETESITTSKAPAESSSSSSESSGSSEFESSSESESSSSSSEDEEEMTVPGVEEEEEEEEEEEKETAMAAATVVAMAEESMPPAGGQDFEQDRAEVPLGPRGPMRESLGTEEEVDIEAEDEVPEMQAPELEEPPLPMGARKLEGSPEPPEEPGPNTQGDMLLSPELPARETEEAQLPSPPEHGPESDLDMEPEPPPMLSLPLQPPLPPPRLLRPPSPPPEPETPEPPKPPVPLEPPPEDHPPRTPGLCGSLAKSQSTETVPATPGGEPPLSGSSSGLSLSSPQVPGSPFSYPSPSPGLSSGGLPRTPGRDFSFTPTFPEPSGPLLLPVCPLPTGRRDERTGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQPRPPPQLPPLLPATLAPCPTPIKRKPGRPRRSPPSMLSLDGPLVRPPPGPALGRDLLLLPGQPPAPIFPSAHDPRAVTLDFRNTGIPAPPPPLPPQPPPPPPPPPVESTKLPFKELDNQWPSEAIPPGPRRDEVTEEYVDLAKVRGPWRRPPKKRHEDLVAPSASPEPSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKREDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPMDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Subcellular Localization:
Nucleus.
Sequence:
MQADFRAPRRRARVYEELEAPLPVIRSAGEKCVYRAELINQHVLVCHPDHVRKIHNQGYFGKGILSRARPDHSISEKWEDFEDLYLPVVSQARYEELLGWAKASLCAQGMSAEAVDQIFHKLTQKLEIEDVKSELREAEGAKTEDGVCDNTKSLGRESEAEPEAKRPCRSDIQDLNFDQNSEPSFDSDQDSEPDLGFQVPGPGFVLVVSENQNEGGVREVKRSPLSLTEYLQLSLEEAFFLVYSLGCLSVYLDQEPQSVIQLWRRFRSLRPDFTSSYAAYHHFRSRGWVPKGGSGAKYGVDFMLYRKGPPFYHASYSVVVEQTDDEFRGSTLRPFSWRSFAALSRITASVSKELMLCYIVYPGELLKEELDSPVCLSKLKVQEVIISRWVSSKERAEQDDD
The following text describes a protein:
Function:
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Sequence:
MLLDEIKRMSYDELKRLAEDIRKRITEVVLKNGGHLASNLGTIELTLALYRVFDPREDAIIWDTGHQAYTHKILTGRDDLFHTIRTFGGLSGFVTRRESPLDWFGTGHAGTSIAAGLGFEKAFELLGEKRHVVVVIGDGALTSGMALEALNQLKNLNSKMKIILNDNGMSISPNVGGLAYHLSKLRTSPIYLKGKKVLKKVLEKTEIGFEVEEEMKYLRDSLKGMIQGTNFFESLGLKYFGPFDGHNIELLEKVFKRIRDYDYSSVVHVVTKKGKGFTAAEENPTKYHSASPSGKPKMLSYSELLGHTLSRVAREDKKIVAITAAMADGTGLSIFQKEHPDRFFDLGITEQTCVTFGAALGLHGMKPVVAIYSTFLQRAYDQIIHDVALQNAPVLFAIDRSGVVGEDGPTHHGLFDINYLLPVPNMKIISPSSPEEFVNSLYTVLKHLDGPVAIRYPKESFYGEVESLLENMKEIDLGWKILKRGREAAIIATGTILNEVLKIPLDVTVVNALTVKPLDTAVLKEIARDHDLIITVEEAMKIGGFGSFVAQRLQEMGWQGKIVNLGVEDLFVPHGGRKELLSMLGLDSEGLTKTVLTYIKARSREGKV
The following text describes a protein:
Function:
Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
Sequence:
MRVVRVRRVSPPPPSFLGGSPPRPPSKGRWYIPSDSKRLKGAREGEPHRSEPDLCARRISNEPGSTALPAAGGSETRTQPAPHEMEQTEVLKPRTLADLIRILHRLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSPKEGEKRKALGKKTLNVKWIFSMCSIHDHTNSHCFLKMLQGNLKETLFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPYATSGSLENN
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRVKSFWRKDTKANLKFNSKPSNVSTSSNFSTLNPNNPKVPNIIKQTIAYIEEYALHEKGLFRIFDNQANVNSLKIAFEKYESIDLSKISSPHVVTSVLKLYLRELPEPLCTFNSYEALIASYIISDPEMRLSVIKSIIQKIVPHHYVVLDYLMAFLYRISNNQNGENGENENSNNNNNSDDQQVPHQQKLIDLKHNLDSSNLAMIFAPTLLKSKSETPENLIADSPRSSKIIKILIDNYSKIFEKDPFTGDSIHVNPLKPFFEEDYLLSSKYETINLDREIAGIFEEEDELSKSMGGFTCDSSGILSKTSCGENGTSDLNSSSVVSPSAISGKSRPSLFQVFGQNQPSIAAAGIVSYNGSRLSVISNDSSASSPDISHDIDDEEEEELKKPNYNELLQNNESNNNSNSNNNNNNVNNNNNDSTTTTTTSTSITNNKEIEFKIQVIKELIDKTIVELENEFIQLGKELQDNLSFQEIVLVASSLKSIMNILVDGPDVDTQVVSSFELDNTMVSTDDQQIKRLEVLKNAMLQKINNSIPSLLLELKEEASSLISQEDIEKDICLVDLITIMRTLKAVNDVLDFFFSKWCTIGTISTSPQNQSPVLNQKHPQQSQQQPQQQSQQLSSSPKQQHQLSSSPSSQPSTLSSSQQQLLLKQQQQKEKEQKEKELQQKEKDKVIIDNLDEREFIIIIQPKEEDIIQNVLDIDMVLFEAEETLMGITSKSELIYIAKVVQNIQKIVRLPIGMPGSFDEIPPPKINTLKITPKHKLAPLVSVVYVLIKEIRDQIIQFREDFEKLKNKNSSQTYSSKDLVYYQQRLLDLWRLLSKLPAFNTYKTSHRNRQEISQKNCQYMRETIESTLKKLEPIFNQLKDDINSKNEISLDSLMLISRSVTKIRKLFEESQLYQRTSIKFAPFTLSKSNQSISLSAETLSISQQPLSPTTINDKISTLKNLTSSIIDQILLRFNQIEDHFNNINQENYLFEIINILKLVITNFKDIKNLNLK