lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
Sequence:
MDTPSAALHRHTVGQLRKLLLHREGSAGCGRLQPALDGSQPLDSPLSTVPSSRSQVRVQQELWKQDPTYFQKAALSALACMKILRHAFDGGDMEVLGMLLGYVQDEMIVVVDSYRLPVEGTETRVNAQMESYEYTVQYLETAVPEGLAIVGWYHSHPGYGCWLSGIDAETQTLNQNFQDPYLAIVVDPKRSKASGVIDIGAFRTMPETADTRSVSSHSNASRYGHHSARYYELEVSYFEVPQERRWCDSRLSVEPPKPADATERAMLAQLLEAAKACKNVKRLQTVDRALVPESIGPYALREQADQDLQFRRPLRSFSSNSIARRSSTEVALGNANEELDPLPTLADANLRNHDSPSADMAMDNTSISSNEEQPHLTFQESSGVQLNAAETEYFDIKNELLTLKLLEYQKARFYRDAFTL
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MATSSSVVVLAVLATVAALVSPAMSLPVFTGDVGVSPGFHAASCPQLDGVVRSSVVAALRQEVALAAGLLRLYFHDCFPQGCDASILLNTTSARAGPVLGRGERGGRPGPPKARGPLPAGQQQDLSSLRPNNRVMSSTGRKYSSVSHKRKKEEGGRLMAIRKMMVILLQKAMLTSTWMIAIVAALVESFGTRGLGDVADLVALSGAHTIGRSHCGSFADRYRRADDTFSRKLAANCSKHPDRLQNLDVVTPDLFDNGYYKALRFNQGVLTSDMALVKNKTTAAIVKRFAQSKDAFFRQFARSMEKLARAPKPAGNVGEIRRFSCFRTNAQRADAAVDAAGEEEEGFAASA
The following text describes a protein:
Function:
Putative tyrosine-protein phosphatase required for protection against superoxide stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MLVPPPNYGMVEENFYRSGQPDQLNFPFLEKLGLKSVIWLAPEEPEPGFLDFCVDQNIELHHLGVLYSTNAWDPITEEVVLQALHLLVQPATYPVLVMCNLGRHRTGTVVGCFRKLQRWNLSAILEEYRRFVGGQKYRILNEQFIELFDEELVFGASY
The following text describes a protein:
Function:
May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MTSRALLLLASALLGTPGLTFSGLNPESYDLATAHLSDGEQFCQGLTQEDLQGDLLTERERQGIACWSCRKILQKLEDLVGEQPNEATINEAASRVCRNLGLLRGACKKIMRTCLRLISRDILAGKKPQEVCVDIKLCKHKAGLI
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSDDILFDSKNYFYLGNYQSTINEINKKSRQIQDKSLKSEADYYLYRSYIAQGNYELVLTETRGNDHPTVCGLQLLATYLLNPQDNRENAMVTVTQWIADGIVRNNYHLQVIIATVFFNEQLFEDALRILNECDSVEGYAMLIQLYLKIDRLDLAQKAYENMKKIVDPDATPALLALSWINIFNGEEKLKSALSIFEEMSERYGATPLLLNGQAVCALSMRRFEKAESLLLESIDKNQKNADTISNIITCYINMKKPNEIIQRYLNQLKSLQPNHVWTVAVNDAEQLFDQSKSRFN
The following text describes a protein:
Function:
Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MSHAMDDDDDDLYDPADAVPVTNPSDPRGPSADAPMNDNVEEEEEEVEEDDEDDFNIITEAPPDAPPPETSHPRHANLRTESQRPTSADSTSAQKSQTPTLTPKVDTSASVPAGTRPTSQKPGSAYPPVHASNIDVNANPVHPATGKPILMTDMDADFPDDDKPWRRPGTDLTDYFNYGFDEFTWASYVLKQQELRKEVGDQKRQLDDMQNFLTMGLPPMPGAQPGAGPAAVSAPPPMPGMPGIPDMNPDMMQGMLASMMSQGLDPSSMDPMSFMQHAQTMMGGQSGAGGGQQGQGGFGGQGGGQSQMGYGNAGGGYGGGRGRGRRW
The following text describes a protein:
Function:
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Secreted, extracellular space.
Sequence:
MPRTHFLLEQQTETQSPSLGGAESPLFLVCVTLGTASALPLLCFLLTLSEVGSQNSKACALPCPPNSSCVNGTACRCAPGFISFSGEIFTDPLESCDDINECGPPSPVDCGSSADCQNTEGGYYCTCSPGYEPVSGAMIFRNESENTCRDVDECSSGQHQCHNSTVCFNTVGSYTCHCREGWEPKHGLKNKQKDTICKEISFPAWTAPPGIKSRSLSAFFERVQKMSRDFKPAMAKKSMQDLVGSVDDLLKNSGDLESLDQSSKHVTVTHLLSGLEQILRTLAKAMPKGSFTYRSLDNTELSLVVQEQGKGNVTVGQSHARMLLDWAVAAAAEESGPTVVGILSSQNMKKLLANASLKLDSEKLKETYKSPVRGAKVTLLSAVSSVFLSNTNTEKLDSNVSFAFALHEQPELKPRQELICAFWKKDSNGNGSWATTGCWKMGRGNGSITCQCSHLSSFAILMAHYDVEDPKLALITKVGLALSLACLLLCILTFLLVRPIQGSRTTVHLHLCICLFVGSAIFLAGIENEGGEVGTRCRLVAVLLHYCFLAAFCWMSLEGVELYFLVVRVFQGQGLRKLWLCLIGYGVPLIIVGISAGAYSKGYGREKFCWLNFEGGFLWSFVGPVTFIVLGNAIIFVITVWKLTQKFSEINPDIKKLKKARVLTITAIAQLFVLGCTWVFGLLLFDPESWVLSYIFSILNCLQGFFLFVLYCLLNKKVGCRPGCGRSWAPPPVLGPVLP
The following text describes a protein:
Function:
Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
Subcellular Localization:
Nucleus, nuclear pore complex. Lysosome membrane. Nucleus envelope.
Sequence:
MQEDDSVKPFQTVGAHRDLIHCVSFDPHGRRMATCASDMTMAIWDRKPDGNWRRSAHWKCHGGAVWRVIWAHPEFGQIVATCSYDRTIVIWEEQIVRSEKDLKQKESQWIRRTIISDNRSDVTDICFSPRHLGLMMASCNVLGTVRIYEAPDIVDASRWNLIHELQAFHTRCGCVTWSLSRMHRPLIAVGSDEKKAENKKRVVIYENIDGLRKWQRINSLVFDLPCPITDLKFSPISMVDSHQLAVASGDVHVYNIKVARSAILEEDGVENPIQLADYNLIKVALLGDHRKAWRLRYNLMGSVISSTSLDGTLRSWKSLFVNQWVKLSEMNVDDYVPSPEEVRAFISSKTTERLPSQLEKTYF
The following text describes a protein:
Function:
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSTQSLDGVVEESSSPIVSPISALVAVILPHSHKVAAARKTRAKSIPESISSIAENNGDLITELAIRVTALDGVSVSTTRDVDVSVLPLSSLDGTGGFGQATNLILDESHERVYSTKARVEQLVLGLYIIRGDNIEVVGELDEELDSNLDLSSLRAHPLKPVEH
The following text describes a protein:
Function:
May be involved in the biosynthesis of 6-O-methylglucosyl-containing lipopolysaccharides (MGLP); Regulates host peroxisome homeostasis in response to intracellular redox levels to favor mycobacterial infection in macrophage. Induces the expression of host peroxisome biogenesis and proliferation factors as well as peroxisome associated enzymes. Inhibits the induction of host pexophagy mechanism by down-regulating the expression of pexophagy associated proteins and adapter molecules in infected macrophages. However, during increased oxidative stress conditions, it induces degradation of dysfunctional and damaged peroxisomes. Regulation of peroxisome biogenesis and degradation is dependent upon host p-mTORC1 mediated signaling pathway.
Sequence:
MNVLSLGSSSGVVWGRVPITAPAGAATGVTSRADAHSQMRRYAQTGPTAKLSSAPMTTMWGAPLHRRWRGSRLRDPRQAKFLTLASLKWVLANRAYTPWYLVRYWRLLRFKLANPHIITRGMVFLGKGVEIHATPELAQLEIGRWVHIGDKNTIRAHEGSLRFGDKVVLGRDNVINTYLDIEIGDSVLMADWCYICDFDHRMDDITLPIKDQGIIKSPVRIGPDTWIGVKVSVLRGTTIGRGCVLGSHAVVRGAIPDYSIAVGAPAKVVKNRQLSWEASAAQRAELAAALADIERKKAAR
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion.
Sequence:
MAVKPSANLGKAFQLPHPFNSCVYIQIPPQPTWSINEYWERNPNKQYLDESDTTYLEELTLTPIEKHQALEKLNTIISAADRLQEVDTKNVDPMYTCVDEREMYMNSGQDGETVNKEEILGNAHKIFQDYFTAPTSEKMRSSSDLNAKE
The following text describes a protein:
Function:
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKFRVYGQSRLSGSVNISGAKNAALPILFAAILATEPVKLTNVPELKDIETTLNILRQLGVIANRDETGAVLLDASNINHFTAPYELVKTMRASIWALAPLVARFHQAQVSLPGGCSIGARPVDLHISGLEKLGADIVLEEGYVKAQVSDRLVGTRIVIEKVSVGATLSIMMAATLAKGTTVIENAAREPEIVDTADFLNKMGAKITGAGSDHITTEGVERLTGCEHSIVPDRIETGTFLIAAAISGGRVVCQNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPKAVNIRTAPHPGFPTDMQAQFTLLNMVAEGTSIITETIFENRFMHIPELIRMGGKAEIEGNTAVCHGVEQLSGTEVIATDLRASISLVLAGCIATGETIVDRIYHIDRGYEHIEDKLRALGAKIERFSRSDEA
The following text describes a protein:
Function:
Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis (By similarity). In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet. Note=Co-localizes with BSCL2/seipin in the ER, upon LD formation dissociates from BSCL2/seipin and relocalizes to LD surfaces during LD maturation.
Sequence:
MAKEEPPSVSRDLQELQRKLGLLLESFLNNSKVVAFMKSPVGRFLDRHPFVTLTVLMFVTMSAIPVGFFLLIVVLTSLGALMGAILLEGLVISVCGLSLLCVLCGLGFLSLALSGIAMMSYVVVSCLMSYWFSPSRPLTQQNANVDCQLAMKFTESERLIF
The following text describes a protein:
Function:
Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.
Miscellaneous:
MISCELLANEOUS: A signal sequence is predicted but has been shown not to be cleaved in the endoplasmic reticulum; MISCELLANEOUS: [Isoform 1]: Intralysosomal proteolytic cleavage is faster and enzymatic activity higher than isoform 2.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain.
Sequence:
MTGARASAAEQRRAGRSGQARAAERAAGMSGAGRALAALLLAASVLSAALLAPGGSSGRDAQAAPPRDLDKKRHAELKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKPSAAAASVSTQHGSILQLNDTLEEKEVCRLEYRFGEFGNYSLLVKNIHNGVSEIACDLAVNEDPVDSNLPVSIAFLIGLAVIIVISFLRLLLSLDDFNNWISKAISSRETDRLINSELGSPSRTDPLDGDVQPATWRLSALPPRLRSVDTFRGIALILMVFVNYGGGKYWYFKHASWNGLTVADLVFPWFVFIMGSSIFLSMTSILQRGCSKFRLLGKIAWRSFLLICIGIIIVNPNYCLGPLSWDKVRIPGVLQRLGVTYFVVAVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGDDHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWSLSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRKKIFWKI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MELREEAWSPGPLDSEDQQMASHENPGPPHETTTTKCLLLHPTKHPGYLNNPSFLQNIHLPWMDILIMDDDDVPSWPPTKLSPPQSAPPAGPPPRPRPPAPYICNECGKSFSHWSKLTRHQRTHTGERPNACADCGKTFSQSSHLVQHRRIHTGEKPYACSECGKRFSWSSNLMQHQRIHTGEKPYACPDCGRSFTQSKSLAKHRRSHSGLKPFVCPRCGRGFSQPKSLARHLRLHPELSGPGVAAKVLAASVRRAKAPEEAAAADGDIAIPVGDGEGIIVVGAPGEGAAAAAAMAGTGAKAPGPRSRRAPAPKPYVCVECGKGFGHGAGLLAHQRAQHGDGLGAAGGEEPAHICVECGEGFVQGAALRRHKKVHAVGAPSVCSHCGQSYYRAGAGGEDDKDDDDEAAGGRCSECRGGEGR
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MAASMDEDITANPPPSSEEDPLAEERLGFVREVGAQAVWSLSSCKPGFGVERLRDNIMDTYWQSDGQLPHLVNIQFHKRTNISQIYIYTDYKLDESYTPSRISIRSGTNFNDLQELQVMDLTEPTGWVQIPIKDGNVKSIRTFMLQIAVISNHQNGRDTHMRQIRIHAPVEGKHYPLELFGKFGTVDFQKFATIR
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Colocalizes with ASCC2 in nuclear foci after DNA damage by alkylating agents. In the absence of DNA damage, colocalizes with the spliceosome components SNRNP200/BRR2 and PRPF8 in nuclear speckles.
Sequence:
MAEQLSPGKTTDQVCTFLFKKPGRKVAAGRRKRPICNQESGDSSSSSDEGNTVVRPEKKRAVHNPMIQKTRGSGKQKVAYGDLSSEEEEENKSESLGVVYKSTRSAKPVGPEDMGATAVYELDTEKERDAQAIFERSQKIQEELRGQEDDKIYRGINNYQKFMKPKDTSMGNASSGMVRKGPIRAPEHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQIERELDEGRYGVYEDENYEVGSDEEEIPFKCFICRQTFQNPVVTKCRHYFCESCALQHFRTTPRCYVCDQQTNGVFNPAKELIAKLEKHRAAEGGGASGFPEDPDEDPVPIT
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function.
Miscellaneous:
MISCELLANEOUS: Present with 6280 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MVAYSPIIATYGNRAEQFLETDSDFAKYHAKLNKKLQHLRSRCHLVTKDTKKYSSKNKYGEINSEDYDNKTKLIGVLILLHAERDLALAETLKLRARQRGKLKKSEEKVLSTRLKKACKTADKLVNVTQNEQQWITRAQYLAFAKLVHSEYLINGKRFKRKDNAKISNNLALVFAALEHLKNLSLLAEEVVDNIVNKYQYSLKQYAGNLITTPEINNFIVERVQSDENKDDELVKLLLDNGFNMKKITTSTEDQKVTTNINWRSFNAKIIDAEVAQFLEQGLSIHPTQITQYTQRLSKLEKALDRHEFFIANHDDQDDIDEMVENSSENNQIILAYIKYNILLTSISRERDLFTHLWNQWLKLNTSLPSKLTKYKEMERIVKNLTKYLSDIMELPGVYSDDELLSQLDLCKLYFQLFLNTGCLSVLYQSKGRYMEALALYVDAYRRLENKLSEIESLDEILLPANLLSLNSVRSLQKRIENGGNSVITLAEYEKRNHGGSLGKYDLTVIEKLDSKKILPTDIQLKNLFPLKPKMLPIPSKPTLFDLAFNYITYDKQEPSASQVKDSVTETESISQTPISNEQTEGEPKKKRGFLGLFGR
The following text describes a protein:
Function:
Converts the D-glycero-alpha-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNRALFLDRDGVINRDDGYVFEIEKFVFLDGIFELAGAAKALGYLSIVVTNQAGIGRGYYSEDDFFRLSDWMKGVFATEGAPIDGVYFCPTHPEHGIGRYKVESRFRKPNPGMILAAQHDFDLDLGASLLVGDKESDIQAGSTAGVGTTLLICDRDASRVATAASAVVRNPRDVIPFLTGPGPDAGSF
The following text describes a protein:
Function:
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Sequence:
MAGELKRSNSTFNISASPKLFTLAIVNTGGRVLLGLKKRGFGEGYFNGFGGKLEEGESIDEAAARELEEEACISPVGMKKHGVLMFFFDDRPCPWEVHVFNVPDYMGKPCETEEMLPTWFAHEDIPYDLLLDWSVENTILTLVFQLVFIMYDCIDGTVHSSTNLGKKRLTLSRVVNNHKGPQILIGMVKIPGAEERDSLPRSARWDAIVESNP
The following text describes a protein:
Function:
Beta-alanine transporter required for the uptake of beta-alanine by the glia. Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission. Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPDITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRASPKKRILPEAGTPVFHRVDTPVSDRVPCKIVCSICKNEMRTL
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Mitochondrion.
Sequence:
MSIPVMQLKHELALKAREEYLRKELPLKVRANTSRMNPGAKTWIPQINHRKSRNHYNRKETCQFPPLYNVEAKINHSYSAFYRPFTKRENGLWYANPYYMQHGPNGNYHHVYY
The following text describes a protein:
Function:
Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS).
Sequence:
MKRLGSVQRKMPCVFVTEVKEEPSSKREHQPFKVLATETVSHKALDADIYSAIPTEKVDGTCCYVTTYKDQPYLWARLDRKPNKQAEKRFKNFLHSKENPKEFFWNVEEDFKPAPECWIPAKETEQINGNPVPDENGHIPGWVPVEKNNKQYCWHSSVVNYEFEIALVLKHHPDDSGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPSLKHNDLVSWFEDCKEGKIEGIVWHCSDGCLIKVHRHHLGLCWPIPDTYMNSRPVIINMNLNKCDSAFDIKCLFNHFLKIDNQKFVRLKDIIFDV
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MSRQVFVALRYGSMPMLGLGLLQVKAGENTVGGEDMTPVTCLVKPKDLPVYSEPEQTEYQLIPEGPSALRDMVGTVREQIWRFSDTFNGAISFTQRTYKSAEQTTQSVVKFIKTEEGFYPRAGVISIAGLAGLVLARKGGFFRKVLYSGGLMTATASLCYPYQAVKIGKAEIEWVQTKAADLYKGATSTPAVEKVAATEAKTEEDTKAETSSSEESAEKVEESKSGTSLEDHGQSKPEDKDMYTTRS
The following text describes a protein:
Function:
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVYIILQWFSGFISFQINFQKVLILIALLAFISSWTYKLKVLNKYSFLPKTPQLTKTFKNQDASRDLNPNLLLNSKQLFSNHDHFNNYLDEFLSAIRVFGFLEKPVFHELARHLQTRRLLAGDTLSLDEDKSFYIVVDGSVQVFAQTSDRARPGQNPGSPAGDAYNDRLAYDNEDDNGFQLLNVVESGGTLSSLFTILSLLTEGVKLRYEEDEGQTDQAFSPDFVDHSPQTSQGQPHHIPTVASSPSVLPPSASAVDPENNPGDWHAINPTESVPHDGRKFPDWNKDTNEDGGDTDDDGQSVETSRRSTYTSKTTTRQSLDRAGSRQALRKDASQTHPASGTINQMPDRDCDYGFARRTDPYASFSPTPQHHGPSYATDPTTKKPREAYSRHIRDQIFENAQPKEATIARATKDTTLAVIPSEAFKRLTWKFPNAVAHIVQVILARLQRVTFLTSHRYLGLTKELLRTEKAFNEIACYPLPPSFYEDGGMIRLRHRFMPSSKLTDEPYVLAGSHMSSDYHMNSGPRSSMNEFFKQPTTKTEPQQPWNDLYIDISRSTSQNGPCSPDSSGEQYPRRRSRHRYSNLSHDLSAPFQMPFSATNHLHEDLALRELVMKSIAKSIGLVQQPPPKNRGSNKGSVSHIHSSSPTPFSSASRAGFSPEPSIQGSGGGGGGGKPALRPGFRSGLGSLSYLKTLGDSSQERRDEFQDTSSSVASSSALLDEEEEKEDLPNEVEIMYFPQDSTLVKAGERNAGLYFVIDGFLDVFMPPEHDKMSPSNTSAEKPTSSSKKDHPSKARNVSDDNEFSYLRKDYVKMQKSRSTKSTRNPSKSSAAPKPTSQKSQQKPAPKNEQTKLFTIKPGGIAGYLASISGFPSYVDIRAKTDVYVGFLSAKALERIMDRRPIVLLTLAKRLISLLSPLVLHIDTALEWMAVDAGQIIYREGDNSDNLYIVIGGRLRSISEQTDGGVEILAEYGQGESIGELDCITNTSRKSTLHAIRDSELVRIPMTLFNAISIRHPAITIQVSRLIASRVRREVDASKSNSLKSRSHGPDYAVSTNRTGMPAPDEPGRGSIRELGMSNFNLKTVAIIPNTKEVPIVEFATRLKAALSQMNASTKMLDQSAILSVLGRHAFSRLGKLKLTGWLAELEQKFRIVLYVADTAVNAPWTQTCIRQADYIMVVCDGGSQPEVGEYERLLSSMKITARKELVLLHPDRNVPAGSTRPWLKNRPWLHAHHHVQMAGATPLNNNHLDELLPLTALRQLKRRVQTRLSKYRGYQMPSEFQIIKRGLANNDFARLARRLCGKSIAVVLGGGGARGISHIGVIKALQENNIPIDMIGGTSIGSFIGGLYARNSDLISTLGRAKTFSARIATYWRLLTDLTYPVVAYTTGHEFNRGIYKSFYDYHIEDFWLPFWANTTNITWSRMEVHTTGYAWRYIRASMSLAGLLPPLCDEGDMLVDGGYIDNLPVSVMLRMGADSVFAVDVGSIDDTSPRNFPESLSGWWLLIRRLNPWSSAYDIPTMTDIQSRLTYVSSVKTLEDAKATPGVLYMRMPVTEFTTLGFGRFEEILKKGYEAAKEMLKELDSEGKLPTGLDDGTNGSDSIIGIPGHRPYHNSKNGGNGSISENTKRQRLNVRRNSL
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSALFNFHSFLTVVLLVICTCTFLKMQFPTILEQKTGLASPCQSLIVSNLIAIDLYFDNPGFRFRGFFWKAARIGERLSPWVAVGCLSMGVSIIFF
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSDHGITHRPSSISSSTPLMETPHKPKVKSLNNAELAFLFNLPATPEVAATWIIKNLCHFGPFYVLVLWAGLSISLVLKCKISLLLLIATTIITKQYLMMLQLMPKACIHRAFDKMAILVLMAIVTTVGLILTQAAVHLFATLWIGLPVILAHSVLWRDGLFVNEEVSASASAPGELASLGDNVHFI
The following text describes a protein:
Function:
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Sequence:
MQSLLIRNARMVNEGQVREGDLLVRHGRIERIAGCLENCGASREIDAAGRYLLPGMIDDQVHFREPGYPQKGSIASESRAAVAGGITSFMDMPNTRPATLSLEALAEKKRLAAAHSVANYGFHFGVSRDNLDTVAALDPREVAAVKVFMGASTGDMLVDDLPTLERLFASVPTLLLSHCEDTPRIEANLARWRQRFGERIPAAAHPRIRDAEACYRSTALAVELAQRHGTLLHVLHLSTARELALFEDKPLCQKRITAEVCVHHLLFDDSDYARLGHLLKCNPAIKSREDRDALRRALAGNRLDVIGTDHAPHAWAEKQQAYPQAPAGLPLVQHALPALLELVREGWLSLATLVAKTSHRVAELFAIADRGFLREGYWADLVLVSELEHPALASAMPLLSRCNWTPFRHRAFHHRIDTTIVSGQLAWHAGRLSDDCQGLPLRFSR
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MQKALKLGSFFARSAISVKPTLATSKMTQLRHFSHGASVFDIDSVEDFTEKVIQSSVPVIVDFHAEWCGPCQALGPRLEEKVNGRQGSVLLAKINVDHAGELAMDYGISAVPTVFAFKNGEKISGFSGVLDDEQLDDFIEDVLAA