lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-binding protein, which specifically recognizes the GL1 enhancer sequence. May be involved in leaf initiation. May play redundant roles with GPL1 and GPL2 in cytokinin responses by regulating the transcript levels of type-A ARR response genes. Involved in stress responses. Plays a repressive role in cell expansion by counteracting the positive role of CPR5 in this process, but does not regulate cell proliferation or endoreduplication. May play a role in plant defense.
Miscellaneous:
MISCELLANEOUS: Overexpression of GEBP results in a reduced plant growth, a delay in flowering, a reduced anthocyanin accumulation, a delayed senescence and an enhanced resistance toward a virulent strain of the biotrophic oomycete pathogen H.arabidopsidis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus.
Sequence:
MVTPKQIDFSSCVGADNSNGTLSHRRSPRNIPSSKRAASVAEEETMKKKMKMKKKKKKLDPPLIVRIWNEEDELSILKGLVDYRAKTGFNPKIDWDAFCSFLGSSIVERFSKDQVLSKIRKLKRRFHVHSEKINQGNDPKFTRSSDSEAFGFSSMIWGQGDDDGMDKEHEVNGNGAAENRTNESGEEMLKEHEEEVANTELLNENGAAKTTENGTSSGKERHDEDNDDDDELCAVQDAFEAVMSQGLSGYQKKLQLEKLMNLGNGKRRELSDEWKALCVEETRFNIKKLRFSAKLAEAANDS
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Miscellaneous:
MISCELLANEOUS: Present with 2020 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.
Sequence:
MSIDLKKRKVEEDVRSRGKNSKIFSPFRIIGNVSNGVPFATGTLGSTFYIVTCVGKTFQIYDANTLHLLFVSEKETPSSIVALSAHFHYVYAAYENKVGIYKRGIEEHLLELETDANVEHLCIFGDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNKLTVVTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFARMALPSTSVRGNDSMLSGALESNGGEDLNDIDFNTYTSLEQIDKELLTLSIGPRSKMNTLLHLDVIRKRSKPKEAPKKSEKLPFFLQLSGEKVGDEASVREGIAHETPEEIHRRDQEAQKKLDAEEQMNKFKVTGRLGFESHFTKQLREGSQSKDYSSLLATLINFSPAAVDLEIRSLNSFEPFDEIVWFIDALTQGLKSNKNFELYETFMSLLFKAHGDVIHANNKNQDIASALQNWEDVHKKEDRLDDLVKFCMGVAAFVTTA
The following text describes a protein:
Function:
May act as a carbohydrate transporter. Required, together with ENODL11, ENODL12, ENODL13, ENODL14 and ENODL15, for male-female communication and pollen tube reception and burst at the synergid cell surface of the female gametophyte.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAQRTLVATFFLIFFLLTNLVCSKEIIVGGKTSSWKIPSSPSESLNKWAESLRFRVGDTLVWKYDEEKDSVLQVTKDAYINCNTTNPAANYSNGDTKVKLERSGPYFFISGSKSNCVEGEKLHIVVMSSRGGHTGGFFTGSSPSPAPSPALLGAPTVAPASGGSASSLTRQVGVLGFVGLLAIVLL
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.
Sequence:
MTRMDMNQLMQTFLAESRDLLEDMERHLLQAERGESSPDAVNAIFRAAHTIKGSGGLFDLPQLVGFTHLVESVLDLVREESVALQSELIALLLVCCDHIHALVETAADPSHADPAALAAEAEPLLAQLQTYLQGSVCGATVSDAQRSTPEKQSGYWRVNLTLFADALRFGNSPLKLIRNLRGLGSVESISTDYSKLPVFEELDPEANYLGFQILLRSDADRAAIEDVFEFVREDCDLEIVAVPAPLDTTLSAATAIVTAEPVHAPAPAIAAVPPPRAAATTAETAPRSNEARSIRVDADKLDRMIDLVGELIIAVASTGTNAQRTGDAQLLESTSILAGLVEEVRESALQLRMVKIGGTFSRFQRVVHDVARELGKDIALVVAGEDTELDKSVVEKIGDPLTHLVRNAMDHGIEPADVRVANGKPARGTVGLNAFHDSGSIVIQITDDGGGLNRDKILAKALERGLVEPGRQLSDREVFAMIFEPGFSTAEKVTNLSGRGVGMDVVKRNITALRGCVDIDSTAGVGTTISVRLPLTLAIINGFQVGIGKSVFVVPLDVVEECVEFTPDYTSDYIDLRGSVLPYVRLRELFALGGKRPARESIVVIRQGAQRFGLVVDTLLGEWQTVIKPLSKVFAQVKGISGSSILGSGEVALILDVPSLIQQLHPGQDALAA
The following text describes a protein:
Function:
Involved in the biosynthesis of the maltose-1-phosphate (M1P) building block required for alpha-glucan production by the key enzyme GlgE. Catalyzes the formation of an alpha-1,4 linkage between glucose from ADP-glucose and glucose 1-phosphate (G1P) to yield maltose-1-phosphate (M1P). Also able to catalyze the elongation of the non-reducing ends of glycogen, maltodextrin and maltoheptaose using ADP-glucose as sugar donor, however the rate of the reaction appears to be too low to be physiologically relevant. GlgM is also able to use UDP-glucose as sugar donor with G1P, however, it is less efficient than with ADP-glucose. UDP-glucose is not used as sugar donor when glycogen is used as acceptor.
Miscellaneous:
MISCELLANEOUS: Maltose-1-phosphate (M1P) is generated by two alternative routes: the TreS-Pep2 branch and the GlgC-GlgM branch, however it seems that TreS-Pep2 branch provides most of M1P for the GlgE pathway in M.tuberculosis; MISCELLANEOUS: Attempts to disrupt both the Rv3032 gene and glgA in order to create a mutant simultaneously deficient in both alpha-1,4-glucosyltransferases turned out to be unsuccessful. Thus, M.tuberculosis H37Rv requires a functional copy of at least one of these two genes for growth.
Sequence:
MRVAMLTREYPPEVYGGAGVHVTELVAYLRRLCAVDVHCMGAPRPGAFAYRPDPRLGSANAALSTLSADLVMANAASAATVVHSHTWYTALAGHLAAILYDIPHVLTAHSLEPLRPWKKEQLGGGYQVSTWVEQTAVLAANAVIAVSSAMRNDMLRVYPSLDPNLVHVIRNGIDTETWYPAGPARTGSVLAELGVDPNRPMAVFVGRITRQKGVVHLVTAAHRFRSDVQLVLCAGAADTPEVADEVRVAVAELARNRTGVFWIQDRLTIGQLREILSAATVFVCPSVYEPLGIVNLEAMACATAVVASDVGGIPEVVADGITGSLVHYDADDATGYQARLAEAVNALVADPATAERYGHAGRQRCIQEFSWAYIAEQTLDIYRKVCA
The following text describes a protein:
Function:
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Miscellaneous:
MISCELLANEOUS: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
Domain:
The Walker A ATP-binding motif also binds Pi and PPi.
Sequence:
MMSVLVKEVIEKLRLDIVYGEPELLEKEINIADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA
The following text describes a protein:
Function:
3'-5' exonuclease degrading single-stranded small RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAEDITATCDKEVLVKIVKLAQTRKIKGIEGEWKDFLQSHDKKFGSSLSDPSRRSIDILAAFVKTITGEEDVKLITNLVKLHENYKSMEFLMKNSQHPESPEQKLVRLTMEHPEYLKRYSFPSYNEDWVITRVGKISKVLKSNAMVAVDCEMVLCQDGTEEVVKVCVVDQNMEVKLDKLVNPMKVVSDYRTDITGITEEDLKDVSCCLSDIQILLKKLLKPGMILVGHSLHNDLQALKIDHRRVIDTSFIFSFLDRPRHYSASLYDLCKLVLGFELRKEGAPHVCMDDARATMKLVLAKLEHGFDEPIAVPLKDDTPESDLTKLLIHKLPATVSLKELLKIFPDMDTVELQPFKTSKSNQSAFAIFKDPTWASKAFDMLDGELGEDSGGRPQKLVSVELKGGQNVSFFVRKMTSKEFPIILKKRLAQVEMKGECKRQKADKSNVCEHIKEIEQLQHKLQEKDQEIKSLQKILSSLTRKHGL
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MMSFSKNATPRAIVSESSTLHEMKFRNFRVAHEKISLDIDLATHCITGSATIIIIPLIQNLEYVTFDCKEMTIKDVLVENRRCDQFIHDDPLQTNLNGLTSQNVLYSDNSIEQSHFLRSKFASLNEYPETDSKSQLTIKIPSSIKISLEDANALSNYTPITPSIKTTPGFQESVFTPITLQIEYEIRNPKSGIKFDTVYADKPWLWNVYTSNGEICSSASYWVPCVDLLDEKSTWELEFSVPRLVKNIGTSKLIGQNGEESEKEKEDTPEHDEEEEGKPARVIKDEDKDSNLKNDEEGKNSKSKDAQDNDEEEEEGESDEEEEEGEEERRNIEESNNPSLRDVIVCCSEYSNIKELPHPIDLTKKKCIFQIINPVAPHHIGWAIGAFNSWSLPLISPPSVDAEDEVEEDKLRENVVDNVNDTMDDDIGSDIIPIQIFTLPTQETDELTVINSTVVCQKIIDFYSKEFGSYPFTCYSMVFLPTAPSKHMDFAALGICNTRLLYPLEVIDKAFSTTNELAWALANQWSCVNITPLDMNDYWCCLGIAGYMVFQVTKKLMGNNTYKYQLKRNSEAIVEQDFEKPPIGSTFTGSSRPISWSSKDLSFIQLKAPMILHILDRRMTKTERSFGMSRVLPKIFLQAMSGDLPNNSLTSSHFQHVCERVNKSKLENFFNEWVYGSGVPILRVTQRFNRKRMVIELGIRQVQDEELGHEKVVGEEGFFKSALDHLEHPDLNRTECFTGSMTIRIHEHDGTPYEHIVEIKDTFTKIDIQYNTKYRRLRKRGGGANDENGVENNNEEKPIVVDVNCLGNVYMSPEECSRFSLTEFNRTSESNELLKQNEAFEWIRIDSDLEWICQMHINQPDYMFSSQLRQDGDIEAQLEAIRYYEDVVVNGGVKSLVYSSILFRTAIDERYFFGIRLAACEALSKYVYDPDFTGGVKHLIQIFQILFCLEDSNIPKSNNFENPKLYFLQCNIPKYLAKVKNENGKCPKLVKQFLLDILVYNENGENKYSDDAYVRSLIENVVKVALNEYKDKAYMEKVKTQLLRYENLVNWLSSYESLIKTTIMYAKYKLHKVGAYDFTELTGMIMHTLTLGINNGDISRESFQNEFLMVLKIMLLEGGLKNKDALVLFTEILCFHEDSYIRDKSVDVLSECVNLVVMDGSLDTISDDIKSSVQSVHNEVKNIKSEDDIELFLSGHYVDDMKIKIEKIGRQNISGLIQICRDMFKGYSPLKILLWDVLNLPVLSLYQRKQIHDLVRVMYTLINSFVVRLETPRERRLVAKMNSNEEGKLDIVIKRESILKVHIKKEVTSTVEAPKKANKIKISLKGDKPVRKVEKQIVKPKVTSKQRKVKSHVNRMGSLPLRFVKIQQQPRVMVHLSSVPYSQFVQITKVTSRSFMVKIRTKNDAKN
The following text describes a protein:
Function:
Transcription factor probably involved in vascular development and shoot tissue organization. Binds to the DNA sequence 5'-CCGAGTGTGCCCCTGG-3' present in the promoter region Box II of the phloem-specific rice tungro bacilliform virus (RTBV) promoter. May regulate tissue-specific expression of the RTBV promoter and virus replication.
Subcellular Localization:
Nucleus.
Sequence:
MDVLNSSSPDSSAKADSSENGDSEEWVGAGVKRSAAGEPAMAGRHARSLSVDSLMGRFNFASPGGAGGMFSLEFGSGEFSPAEMKKIMADEKLAEMALADPKRVKRVLANRQSAARSKERKMRYIVELEQKVQILQTEATTLAAQINLLQRDSSAVATQNNELRFRLQAMEQQAQLRDALNEALTGEVQRLKIATIELGIGDSCSSNGMAQQHNLMFQQQQLLQQATPIPFYQLQHQQQQQQQQQNGTASKHESRE
The following text describes a protein:
Function:
Involved in the biosynthesis of benzylisoquinoline alkaloids. N-methyltransferase methylating (S)-coclaurine. 4'-O-methylcoclaurine and norlaudanine can also be used as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MQLKAKEELLRNMELGLIPDQEIRQLIRVELEKRLQWGYKETHEEQLSQLLDLVHSLKGMKMATEMENLDLKLYEAPMEFLKIQHGSNMKQSAGYYTDESTTLDEAEIAMLDLYMERAQIKDGQSVLDLGCGLGAVALFGANKFKKCQFTGVTSSVEQKDYIEGKCKELKLTNVKVLLADITTYETEERFDRIFAVELIEHMKNYQLLLKKISEWMKDDGLLFVEHVCHKTLAYHYEPVDAEDWYTNYIFPAGTLTLSSASMLLYFQDDVSVVNQWTLSGKHYSRSHEEWLKNMDKNIVEFKEIMRSITKTEKEAIKLLNFWRIFCMCGAELFGYKNGEEWMLTHLLFKKK
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MGCGASSAEDTTKQAEQPAQEKPKAAEPKEDGIPIKKSNAEAKEKILTLGAGECGKTTLWRQLKITYCGGFTDSERRNLINALRTAIVGDIQLLVSTAENSNQNFLTEIQSDIDCIKNLDVAQPDDFTTESAESIAKVWADPAIKNVYKASNSIGIGENADYFLDNVKRIADPSYTPTNDDILKARIRTVGISNLTFDVKGIPTNLVDVGGQRNERKNWSKCFQNVTYVMFVVSLSDFDQTLFEDESTTRTADSIELFKNIASTPIFESTPFFLVLNKFDLFQKKIKKSPEAFNSAYPGFTGDINNKDDCINHIKETFINHLPPNRSPDAWIEAIPTCAMDSQSVRNLFQRIAQKIVEKYPSA
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Sequence:
MLTNIAKKIFGSRNDRLLKQYRKSVARINALEEQMQALSDADLQAKTAEFKQRLADGQTLDGILPEAFAVCREASRRTLGMRHFDVQLIGGMVLHDGKIAEMRTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLASRDAGIMEPLYNFLGLTVGVIISDMQPFDRQNAYAADITYGTNNEFGFDYLRDNMVTDQYDKVQRELNFAVVDEVDSILIDEARTPLIISGQADDNIQLYQIMNTVPPHLVRQETEEGEGDYWVDEKAHQVILSEAGHEHAEQILTQMGLLAENDSLYSAANIALMHHLMAALRAHSLFHKDQHYVIQDGEIVIVDEFTGRLMSGRRWSEGLHQAVEAKEGVEIKRENQTLASITFQNYFRLYTKLSGMTGTADTEAFEFQSIYNLETVIIPTNRPVQRKDFNDQIFRSAEEKFEAVVKDIEECHKRGQPVLVGTTSIENSELVSKLLTQAGLPHNVLNAKEHEREALIVAQAGKVGAITVATNMAGRGTDIVLGGNLKHQTDAIRADETLSDEEKQAQIAALEDGWQAEHDKVMEAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSFEDPLLRLFALDRAAAILNRLAPERGVAIEHNLLTRQIEGAQRKVEGRNFDMRKQVLEYDDVANEQRKVIYSQRNEILTSKDISDLMQEIRSDVVSDLVDTYMPPDSMEEQWDIPTLENRLAAEFRLHEDIQSWLKADNAIDGQDIKERLIERIENEYAAKTELVGKQAMADFERNVMLQVIDNQWREHLAAMDYLRQGIHLRSYAQKNPKQEYKREAFTMFQDLWNGIKFHIASLLTSVQIEQNPVAVVEEQPIGNIQSIHSESPDMEELLGQSQTDLVTEAFNPDGTDFSPEALEARGQIVHRNDPCPCGSGLKYKQCHGKLA
The following text describes a protein:
Function:
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Sequence:
MEIASHLNDSKVVFKKDFSEYGQILNIEFSPFILSQDLILIGFESKVVLGHLKIDEEQSLELDILAEFTLKSRCCSLTFSPETSTSILPNNIIFAAACKDYKVRVFRSDLRGSDVCKVLSEHNSYINDVKFDPDNNFLVSVSDDNTAKLWDTTDFQCVVTLQLTSPGMSVCWHKDDGSKLLIAEKIGLIRFYNVETQNPILSLDYGKPLACAHWAPSDSQLVASLQLGELLIWDLSKPCVPASNTLVFTEAGGFVRFNSFGNLVAAINSLDSTLKIVDCQINQMKLSVPVTLPSNVSWHCRYPIVCVGDYMTLTFWKVVSK
The following text describes a protein:
Function:
Soluble IL18-binding protein that may modulate the host antiviral response.
Subcellular Localization:
Secreted.
Sequence:
MRILFLIAFMYGCVHPYVNADEIKCPNLNIVTSSGEFRCTGCVKFMPNFSYMYWLAKDMRSDEDAKFIEHLGEGIKEDETVSTIDGRIVTLQKVLHVTDTNKFDNYRFTCVLTTIDGVSKKNIWLK
The following text describes a protein:
Function:
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Sequence:
MSSIKEKFNQISPSEFFYSNRDLAGFSNPTRSLYTAVREFVENALDACDQKGILPDVHLTIKAVEPDKPDPKPYILTVKDNGPGVDAKHIPLAFGTVLYGSKFGLKQARGMFGLGATMAILYGQITTNKPVIVKSCADGQTQNQFEILLDIQKNKPVIVKHNTKEASKKGLSVSICLEGDYSKAGNKIRDYVYETSLITPYATITFDDPKGQKFQHTRFVKEIPPPPTIIRPHPHGIDVERIRRMIVESQFEIPTIDDVMIEKVRKDLGLSKQNLSFTAIMTKAKKKWKNLSRQVRVVIALLSFLKMDFEKLSKIRIEDLDVPNKKLHYWDFGDSQSKTVDMDPESQYYKQLTNTVQGEPLTTFLTKRFQRVGPTTAVKFAEFAKFKPEKRMGTLTNQELVNLSDALQKFDDFMAPDSSCLAPLGESPLEKGIKKFFNPDFVAVVQRPASAYSGFPFIVEMGIAYGGDIKSGGPHVYRYANRIPLLYDEGSDVVLKVVNDTDWGRYKVKGDPPFIIVSHICSTRIPYKTAGKENVADRQEIERELRLGLQFLSRKLAAFMSKRGQAEMAKKRANLYAKYIPMIAEFCTELAGKKKEPNYKKILEELEPVEIKTEKTIEEEKPIESK
The following text describes a protein:
Function:
Mediates influx of magnesium ions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MVTLHTFQRQQVQQLTDFDQISELLLQPRTMIWLDLEQPTDAEIALLREEFGFHPLAIEDALQMHERPKIETYPGYYLIIFYSVEYDAKQRTLQFLPVALFVGANYLVSIRSGPVRHVQETLARWQSNGYMPGYQVSSILYALIDAIVDDYFVALDALGEQIDDIEDEIFQRGRHEVASDIFTLKKDLLLLRRIVAPERDILNVLLRQEVRIFHPRELTYVRDVYDHLVRITESIDLYRDLLSSALDSYLSLQGNQLNQLVKVLTLWSIILMSCSLVAGIYGMNFALMPELEQPWGYPFALGLMLTIAVGLAIYFKRRRWW
The following text describes a protein:
Function:
Transcription factor that specifies expression of key genes in developing central nervous system (CNS). Essential for many, if not all, late developing neuroblastoma (NB) sublineages. Binds to the 5'-[CG]C[CT][CT]AAAAA[AT]-3' DNA sequence, like hb, suggesting that cas and hb act as a late regulators in early and late CNS NB sublineage, respectively. Acts by repressing expression of nub/pdm-1 and pdm2/pdm-2 POU genes, and restrict their pattern of expression in appropriate cells. Required for a full expression of vvl/drifter and acj6/I-POU; it is however unknown whether it directly activates these genes. Controls engrailed (en) expression in the ventral nerve cord.
Subcellular Localization:
Nucleus.
Sequence:
MSNQMEFIMQLYMMNLMKQQQQMQLQLPQQQQQQQLAGYTYTQNEDISSSTSVQQQQQQQQEQLQQPQPDLRKTRTHKRISSQNTNCSSSRSCSPNSNLIAFQPQQYPGATAATPSTPNSHPSNLVNQMLLQSLPPLTQLMLQQQQQQHLLTTSNLLLTPTHTPSSLGKQDPLQHPLLLGQFAGSEQMATNNFLQSSTVTSTPIEREKAATPAPSAGATAGNLSAAQVKFEQESADDDEDDDKPLSSLTSCSSSGHTNASSEKLLLSGVHPLESTTDSLDSPSMYTPVKQPADSSYGLITPVDSDLTPNTPLQPTQTISLLTPPSSEQSKSLVSLSAASGLDALLQNEEVLKNLRKVSSYLECENSLCRQENLREHFHCHEEPCQGKILSKKDDIIRHLKWHKKRKESLKLGFARFSSSDDCAPAYGEGCAYNWKQTHYHCVYEHCPKVYVSTSDVQMHANFHRKDSEIVNEGFRRFRAHETCRIEDCPFFGKKISHYHCCREGCTHTFKNKADMDKHKTYHLKDHQLKMDGFKKILKTEVCPFDACKFSTVCNHIHCVREGCDYILHSSSQMISHKRKHDRQDGEQAYQQFKIKQDVEESSLDAMPQQQQQQQQQQPTSLSQSQSSSSVCGGSNTSTPLSSLSAEHFLARKRGRPPKKIQLPADAQQSEAKRLKVEDESSNPAMLLPQSQPAAAVHPLTSGLFPGLLPAAAAPGVDPTAPNFQLTHLMALFQLQNPLFYQNLYPGMTQNSSMLGNLAALSAASAAAAAAAAANGAGVQQPKAEFSFKPEFKE
The following text describes a protein:
Function:
Involved in the biosynthesis of the antitumor antibiotic sibiromycin. Activates 4-methyl-3-hydroxyanthranilic acid (4-MHA or 3H4MAA), a precursor of the antitumor antibiotic sibiromycin, as adenylate. The activated substrate is then covalently tethered to the thiolation domain. 4-MHA is the preferred substrate, but it can also use 3-hydroxyanthranilic acid (3HAA) and anthranilic acid (AA). Has lower activity with 5-hydroxyanthranilic acid (5HAA) and 3,5-dihydroxy-4-methylanthranilic acid (3,5DH4MAA).
Domain:
Contains a A-domain and a T-domain. The A-domain is responsible for selection and activation of a substrate, which is then covalently tethered to the T-domain.
Sequence:
MSALPSLRVPTLPVAFEAAARAAGDRIALEYGSSSITYRELDAAANRFARRLLREGVTPGSRVGLHMTRCLELYIAMIGLLKAGAVVVPLNPSHPVTVRRSVVREADLPLTLRDVPAGLSSVTVERDVHELLAAGADLDDTSPGLCTDPESTAFILFTSGSTGRPRGVRIAHRGIARVASYNGEVEVRPDDCFLQLAPYSFAASTTDIWLSLLHGARVVVLPSQLPSLPKLAHTIKEYGVTFLNLPGGLMNLLIDAHPEAFAKVRTVIVSGDFPSAPHLARVMKAVPGTVYNAFGCTENSALTAVHPMTPEDLQLGVVPIGLPLPGVGLHVLGEDMTPCAPGEVGEMHISGAGLAQGYLGLPEETAAKFPTVDGVRMLRTGDWARTTPAGEVVLVGRTDQMVKIRGFRVELREVELAADQSGLVEKAVVRAVDATDGQKELVLFCTTATGEAPSIEALLADLKSRLPDYMLPARVHHLAELPVNVNGKLDRMALREPRAVLVEPDGTAQQQPVVRDIIATTVTRLLAVVTGREPIGVSDSFLASGANSLQVIQLAASLHDVMGVDVRPEDIFQLDNAESLAGHIRALRQGHREVPA
The following text describes a protein:
Function:
May have a role during differentiation processes.
Subcellular Localization:
Nucleus.
Sequence:
MFKSQGPVLFEDVSVVFTQKEWQLLDAAQRHLYREVMLETYRHLRAVGHNVTKPELICKLEQGESPWEPSGHSLSEVQRADTMTTNEENGGRYLSQIFISDETLTKRRSKDLKEIVHLATDPEASRAIRQKCCSMEASLENITGLVTGNRNHTTKKLDGLGGSRSPDERSHIGCKNCERDPKKKSHSPMEGPTQQQKTSRLEQLLEYQNCGKTSHTKAASVIHQTVHAGQDSKYTQATAHKIRFQSFLRTLRERKKQEASQHGKALCVKSKHEPAGTPVREKLCGRGMLEKPYKEKLDLCRGQRRQPGEPECSVSENAISSSPHLQNEELHVGEKICASGNCGGTLPGKPRLSQNRKTCTAEKPKCADTQTALKTSHQILHPRLSTREKTPKGDECGRSPLLSRKELRCSQYGRPSLGEKPECEGNEKPDHSENQSLCKEQKAHEGCKCEEGCPKTASLPQHQSSHTEKKTYACNECNKSFLVKSHLTEHQRTHTGEKPYECKECGKSFCQKYALTVHQRTHTGEKPYKCNECGKTFCVKSNLTQHQRTHTGDKPYKCSECWRSFCVKSNLVVHQRTHTGEKPYRCLECGKTFYEKSALTKHRRIHTGEKPYECEECKKSFSQRSALTKHQRKTHKKKTPTGSPRGQKSEPTSEAH
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MEQRVGGLLLSQMEEEPTENNKEQKSELDVQKLVSEEGISSLQNKCESISFKGEGYEAEDLQALIQCIQCWANKLFPQLVFEDFVTNLEEMKELPEIQTCLRSLHQDCPSTCAQVDNNEFVKSEEAEFLHAVENGCLKRMCSMGEDKRNLP
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MATKQEALAIDFISQHLLTDFVSMETDHPSLFTNQLHNFHSETGPRTITNQSPKPNSTLNQRKPPLPNLSVSRTVSTKTEKEEEERHYRGVRRRPWGKYAAEIRDPNKKGCRIWLGTYDTAVEAGRAYDQAAFQLRGRKAILNFPLDVRVTSETCSGEGVIGLGKRKRDKGSPPEEEKAARVKVEEEESNTSETTEAEVEPVVPLTPSSWMGFWDVGAGDGIFSIPPLSPTSPNFSVISVT
The following text describes a protein:
Function:
Possible role in modulating immune responses. Has an inhibitory effect on lymphocyte proliferation. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
Sequence:
MSDDNGSGNNCTTNHFLLYGSLGLGGLLLLLVIILFICLCGFSQRVKRLERNAQVSGQEPHYASLQQLPVSSSDITDMKEDLSTDYACIARSTPT
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MSESVLLDEIFTVTSVDKQKYQRVSRITAVSGQNDMNLTLDINSQIYPLEKDATFSLQITSNLNSPDLKEAADYIMYGKVYRVEEAKDEKVSVYVSFGGLLMAIEGSHRKLYRLSLDHVYLLLRR
The following text describes a protein:
Function:
Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MQLREMKDIGEQLYTTQVNGGPSSLTMSPKQPNRATRPERQEAQTLLYQGSEAEAATMTIATCVQCKSIHKIPTQDLRKGPGQGQDTYVCFKCSLRAVPTQLHFVNNNAGAAHIRNETETISSPVNKFKVRNFKPGKYYCDKCRFSTKDPLQYRKHTLQHEEIKFICSHCSYISYTKGEFQRHLVKHTGIFPYRCEYCDYGAIRNDYIVKHRRRVHERAGAKRPFKTVAKLEPKRTNISKQSMELSKAPSPRAAFQNKLSDQLSRFSLHASKDKTHNMMLLPELKKYQKDVVCIPNKVTLCEPREVSLLGNKNVEVEVLSPSKEPVQPGLPLTVMAPSELVVPTNCLAQLMDVKVVNGTQQLVLKLFPLEENSRLETSRGDGGVSECTTTEKGSGGQTKVLSTEASRSLAMEGNAGEFVGLDRLHSLVQKQLKNVKWVKSCNFFMPNSGIHSHQDSFLGPDTIKDLQKSHSLCPPRALPSASVKSHSPASVQSSVSYGPGATVSRFLTKAAAAFAEDGRGSRSDSQQLLPLASLSSKVSFSGEKGLLPLGENDLEARNRTSRPETVVSSDRKLEDKPMESKAVGSTSQVSSVQKKEYLHINFAGEDKTRSQQPGGRPVLPKTSETAGNAFEGPIISSVFSLSSGSENVPEGIKWNSSTTKIKSIELLRRKIAQLIESCGKPSSLSAGSPQRRPIGQAPKLTSKATPKAIQEMSGSLTGPGPSVGPLQKPQNEDSITGSGQHAPQQMCPPFVSANDGKTESRVTRKTPVATPVLIPKGAVLRVLNSSEDARIIEATCDTPVSIPCSEAQLAGTLPFCPVKQPGSGSQLLPCRSGPADLSPSLETSLRPKSRKEDPICSVTPKKIIPVYSTVPGSSDSSRQGRPVSRNLTVSKNKTKQVSSAKKKNKMQANPSRYFKDPSFFQVARQLRLIAAKPDQLIKCPRRNQPVIVLNHPDVDSPEVTNVMKVINKYKGNVLKVVLSERTRCQLGVRRYHMRLTYQNVAETNHMKRQMMLKMKLKKVHKNNYQVVGSLPDDPAQCVFKCWFCGRLYEDQEEWMSHGQRHLIEATRDWDVLSSKGK
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MTVTWKLKLQYGAMLFSVVGCVLTCVSTYVPLWKLLNLDLNEMETWNMGLWQICVVQEEGGMQCKYYDSFLAMPYDLRISRILMFLADGFGVTGLIMSSFGIDCLKFEEEIKKKLSICGGTLLLVSGITLLVPVSWIAYNTVQEFWDESIPDIVPRWEFGDAVFMGWFGAFFLLLGGSLLLCSMMIATKPTFALNKTSGEQYPLAHTSLRYPDQLALTALRHPDLTV