lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds galactose.
Sequence:
MADSSSFFSSAFSSAKNLIPFAKNTEDKPVDADTASDAKDAKDSAIQEAVQNASAAINDVFTDAVDKLEEVKDTVVEQFSNGDEKKEEAVVEEKFDSVHVGVDGETAVQEAKEEVKEAQVVVKGVLADGTQIVEGVTDVAEAPVADEKKEETVAAPLDSAAPVEEHKEESHSSEHTEAPAHTEDSIVQADPEARIVFQGVLADGTQIIEAVSANPPCIQEESAPAAAVSEEVGEAVHVVPVDQAPEAPTSEAQDAAPIEEHVEVVHVAENASTPAATDAHEETKSAEEQTPVVDASPAQEIVKVEEHEHKEEAAPDESAPEAAHDSHVEETAAQVVDEVIEAVHVSANESAPEEHKEEVAAAATSEDQKEPAPASDEHTSESAVEGAIESVHIALTESAPVASDENTTEAAPGTVEEHKNEVHDPVDGASSDAPAEDHREAAASSESVEEPITAVHVEATESAAPADKVHEETKIDSAAETHADAPVVDASPAEDQASEVTEAPHVESAKSAPATSEDHKEDVAQATSEQVETQAPADEHKDDASPAEPTTVQDVIEAIPIVSTESTPAEHSAPAESAPALAEEHKDEAAPSEPVQDVPVEEVIEAVHIAPAESAPASVEEAAPSESTQAPVEEHKDATTAADSSHEEPKAESDAPAAESVETAPVEEHKDEASPTALESVEDVIEAVHVASTESAPAPVEDAASADSTQAPVEEQKDTAAAAEPSHEEAQADHAASVEDVIEAVHIASNESAPTTEAAPSESIQAEDHKDEAASTAEPAHEESVTVVEASHKEPQAESAAPVEENIESVHVASEESAPAPSGDAAPSESAPVSENPVEEVAVAYHVESIESVPTDAQSVEEPVVQQHVGTVEAAPEAAVDEESFDVVHVHSDAAHPETATPESGSEETFEKVEHSQVQEAPSSEEHNSSEPEIVEDVVEKQIVAAVASAPETQPEESPKKPRKLAEMAHESAFPVPYRSKLVEPFEPGQTLIVKGKTGEDSIRFTVNLHTNTADFSGNDVPLHVSVRFDEGKLVFNTFSKGEWGKEERKSNPYKKGDDIDIRIRAHDSKFQIFVDQKEVKEYEHRVPLSSITHFTIDGDVLVNYIHWGGKYYPVPYESGLAGEGLAPGKTLTVFGIPEKKAKRFHINLLKKNGDIALHLNARFDEKHVVRNSLINSAWGNEEREGKMPFEKAVGFDLEIHNEPYAFAVTVNGERFASYAHRLSPDEVNGLQIGGDVEITGIQLA
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MANYSAKGAPSNGSVYVCNLPPGTDEDMLAEFFGTIGLLKKDKRTGRPKIWLYRDKVTDEPKGDATVTYDDPHAALAAVEWFNNKEFHGNIIEVLMAQSKNSHNSVAPLVDPSLVNDVGPDESAFDINGSGARGRGRGDASGNLPQKAWQQDGDWACPNTSCTNVNFAFRGVCNRCGSARPAGAGGGGAGGGGRGRGRGGSDSGGGRGGVGGPTGLFGPNDWSCPMCANINWAKRLKCNICNTNKPGVSEGGVRGGRAGGYKELDEEELEETKRRRREAEEDDGEMYDEFGNLKKKFRVKAQQTEAGQVLPGTGRAGWEVEELGMSDKDRRERSRDRREERENSKNRRRSRSRERDRGRERERDREYNYERDREYARERDQDCHRFFRDQFPLVLHLQCEVLVSWHCFLDNYVVSFANIFYLKHFDINMDFCKPNVSCTGNSLFKTIFDLYDHINMDYTEVKGESRS
The following text describes a protein:
Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Sequence:
GTTGQPKPGRLSHFNVVNNANLVGRFVGYHRQRESICLNAELVFGFGRTIGVLAVTIFGSTIVLPGPNFSPKTTLEAISRHRCTVAYGPSTVFFDVLRELEKGDYDVSSIRKAIMGGTLTNPAIVEKARTRMNARSLYIVYGGGETSPVITCTNPDEPTDRWIRTVGKPLDHVEVCIHRSLVTFSEG
The following text describes a protein:
Function:
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKIDIEKQDSVKVYKIRKTLEELSKKSGRGTELITVYIPKGKQLHEIIGTLQQEQGTADNIKSDLTRSHVVDSLGKVVQRLKLYKKTPERGLVMFCGALPPEEGGPLGSEVVKVWEIDPPKDLNQYLYRCDDHFHVDILKDMLKDDNLIGFLAIDSKDAGWGLLHGDKIEVLAQTGSGVAGKHRQGGQSAKRFQKLREMELTYYFNRVAQTTREYFIDIYPVKGLVISGPGPTKEDFINGNYLEYRLQNNIIATIDSSYSGSEGIREAFAKSSDILGNFRLVEEKKLVEALFREINGNTGKGSYGLQEVIDFLKNNVVETLIITDNTNLNRVEGICKRCKHLQEDIVERPDVIPKKTEYSSKPCPGCNAMEVEVNEQDIVDYLELIASKTGSQLEVVSGSAEHGNMLASLGKIGAILRYNPGHSK
The following text describes a protein:
Function:
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Sequence:
MPVRDIGISNSLSYEEVPIEILDWQVRRLWTKDVTSVKVLQRNHKVEEATWEAKEDTKFKYPFLFSTLRIHAEGVWRFKSCLYCLIHHSRINDPSMGELKHPGFCPSKNSQGFNSSADHTTHHMSSMVRVSGPVVVADGMGGAAMYELVRVGHDNLIGEIIRLEGDSATIQVYEETAGLMVNDPVLRTHKPLSVELGPGILGNIFDGIQRPLKTIAKRSGDVYIPRGVSVPALDKDILWEFQPKKIGEGDLLTGGDLYATVFENSLMEHRVALPPDAMGKITYIAPAGQYSLNDTVLELEFQGVKKQVTMLQTWPVRSPRPVATKLAADTPLLTGQRVLDALFPSVLGGTCAIPGAFGCGKTVISQALSKASLYSNSDTVVYVGCGERGNEMAEVLMDFPQLTMTLPDGREESVMKRTTLVANTSNMPVAAREASIYTGITLAEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLAARLASFYERAGKVKCLGGPERTGSVTIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYSGALESFYEKFDPDFIDIRTKAREVLQREDDLNEIVQVCAFLLFLDFYVIKPPPPPPQQQQHTRCIST
The following text describes a protein:
Function:
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. In body wall muscles, regulates organization of myosin thick filaments.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Chromosome. Cytoplasm. Note=Localizes to the spindle poles and condensed chromatin during female meiosis. This localization requires mei-2. Also localizes to the polar body. Ser-92 phosphorylated mei-1 is first detected on the maternal chromatin in anaphase of meiosis I, then localizes to the cytoplasm during meiosis II and quickly disappears between pronuclear formation and the first cell division, except in the polar bodies.
Sequence:
MNGDVQSVIRGYLERAQVAKTMSDAGRWNEAGDLLRQLMTDVKSCKISASNRDEHDARNTFLRALEANLKLVQQNVRDEDDLHEAMTRQSGSPEPPADPDVWSKPSPPLPSSSKFGATKKGVGAAGPRPREISKSTSSMSTNPADVKPANPTQGILPQNSAGDSFDASAYDAYIVQAVRGTMATNTENTMSLDDIIGMHDVKQVLHEAVTLPLLVPEFFQGLRSPWKAMVLAGPPGTGKTLIARAIASESSSTFFTVSSTDLSSKWRGDSEKIVRLLFELARFYAPSIIFIDEIDTLGGQRGNSGEHEASRRVKSEFLVQMDGSQNKFDSRRVFVLAATNIPWELDEALRRRFEKRIFIPLPDIDARKKLIEKSMEGTPKSDEINYDDLAARTEGFSGADVVSLCRTAAINVLRRYDTKSLRGGELTAAMESLKAELVRNIDFEAALQAVSPSAGPDTMLKCKEWCDSFGAM
The following text describes a protein:
Function:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
Subcellular Localization:
Cytoplasmic granule. Golgi apparatus. Secreted.
Sequence:
MQRLDGHLSGVGGWCFSIQVWCLWGGLDVLWRAPCGSGRPGPCFLAEWGWTRWPLWSLPTLRFYDSMTLTCSAFSPKNISERNQGNVGGRAHQSVSIDNQKQVVNVDNNNGWNSWNTVWDYKNGYVATRVLSKKSCILSRMNPEVMPDVTTLPDAIRIKQKDRTKGPAHKEVTYVVSSKRITDLAPYGKNIQALCRGIPTFPAYESPPPLVPFFWGGGAIAHVHPPF
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MASNAAVPFWRAAGMTYITYSNICANLVRNCLKEPYKTEALTREKVHFSVSKWVDSKPQKPTLRSDTPEA
The following text describes a protein:
Function:
Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos.
Subcellular Localization:
Cytoplasm.
Sequence:
MYQSPRRLCSALLQRDAPGLRRAPGPPPPPRRLSPTAAPRLASPRLLAAASAARDVARSCSRTVYPMGNGTSRLYSALAKTLNSSAASQHPEYLVAPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVALPADGPSSHPPIRVMQWNILAQALGEGKDNFVQCPMEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESSRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQTITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSRQALSVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFTFNEEP
The following text describes a protein:
Function:
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Subcellular Localization:
Cytoplasm.
Sequence:
MEVVIIRVGELTVKRGLTRAEMERLLLRAAREAAEECGGARFEKEPGRIYAYGDVNCLKKALSKVFGVKSVSPARVITYQKITDIALEAADLWSGIVAGKRFAVRVHRVGEHAFTSREVAAEVGAVLVAAGGRVDLEDPELEFYIEIRGNRAYFYTEVIEGPGGLPLGSEGKVLALVSAGIDSPVAAWMLMRRGAHVDVLYCNLGGTITLRHALEVIKRLLAWSYGYNARVIIADCGPVARAMRRGVREELWNIAFKRALYRIGVEIAKRLGAIALATGESLGQVSSQTLQALAAVEAGIDMPILRPLIGMDKDEIVKHAQKIGTYELSAKLPEYCAVFSRRPRKWALREEVEAIDLALYDAITEVVNNAKIVRKRELDEFIKALTPPHDIEIDSAPEGAVIVDLRDEESYKKWHLPGAVRAGVDDVLALVDKLGRDKTYVFYCYSGGLSLDVAESLRKLGIKAYSLRRTRNAVPPSSQGERGN
The following text describes a protein:
Function:
Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.
Subcellular Localization:
Nucleus.
Sequence:
MSTGAFYISSLLEKMTSSDKDFSPKSLGGSRVLDPLPWLQILAAITDWISGDRTQDLALPRFMATSDLMSELQKDSIQLDEDSERKVVRTLLRLLEDRSGEVQNLAVKCLGPLVGKVKEYQVENIVDTLCANMRSDKEQLRDIAGIGLKTVLSELPPAATGSGLAISVCRKITGQLTSAIAQQEDVAVQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHLAAACSTDLFVELADHLVDRLPGPRAPASPAAIRTLIQCLGSVGRQAGHRLGAHLDRLMPLVEEFCNLDDDELRESCLQAFEAFLRKCPKEMDPHVPNVTSLCLQYMKHDPNYNHDSDEEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCMAALISSRPDLLPDFHCTLAPALIRCFKEREENVKADIFGAYIMLLRHTRPPKGWLEAVEEPTQTGRNLNMLRAQVPLVMKALQRQLKDRNVRTRQGCFNLFTELAGVLPGCLAEHMTVLVSGIVFSLADYSSSSTIRMDALAFLQGLLGTEPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVLQELVRTLWPLDRPRLLDPEPYVGEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDRLGDDLEPTLLLLLDRLRNEITRLPAVKALTLVAVSPLRLDLQPILAEALPILASFLRKNQRALRLATLAALDALAQSQGLGLPPPAVRSVLAELPALVSENDMHVAQLAVDFLTTVTQTQPASLVEVSGPVLEELLQLLHSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLTAPVYNQVGDGGPGLHKQVFHSLARCVAALSAACPQEAAGTASRLVCDARSPHSSTGVKVLAFLSLAEVGQVAGPGPQRELKTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFLLAQIEAQPRRQYLLLHALREALGAAQPDNLKPYVEDVWALLFQRCESPEEGTRCVVAECIGKLVFVNPPFLLPRFRKQLAAGQPYTRSTVITAVKFLISDQPHSIDPLLKSFIAEFMESLQDPDLNVRRATLTFFNSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMLARLAALCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQELEKQDELKRSAMRAVAALMTNPEVRKSPSVADFSTQIRSNPELATLFESIQKDTASGPSMDSMELS
The following text describes a protein:
Function:
Probable transcription factor that acts in a feed-forward loop with nhr-10 to activate genes, including itself, involved in the vitamin B12-independent breakdown of the short-chain fatty acid propionate. This pathway is triggered in response to a diet low in vitamin B12, when canonical vitamin B12-dependent propionate breakdown cannot function; the resulting accumulation of propionate is probably sensed by nhr-68 and/or nhr-10.
Subcellular Localization:
Nucleus.
Sequence:
MENKEVCLVCQDFSSGYHYGIPSCNGCKTFFRRTVMKKQKFVCQFDQNCPVDKSIRCACRFCRFEKCLKVGMDKTSLQASRDPIGYTKRNKKTLRHPMNELSGDESNSCTPDRQLSPLRSFENSLNFLAVRERSANELRMSSYLPKRSLKQALCSKPLINDPIFMSKHATVSPRHTFEKLRFITQDDYHYWHERDWFVLTEYAKTFKVFKNMPYHDKTELVCHAAIVIPVLNQVYNSPDYGLDTVVFPDGTYYDRTHEPTRPAGLNRKKYQVLDLVLKPFREMEINFNEFAAFKAITFLNPDADISLESKHAINEERVLITKQLYAYMVQKDGLEKAIYRFGRLILMGTSMSKMACESKEAVWIADFFENIGFTSFAKELIFGDH
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MYSTATSGSKQANVGFGHGQHPHPCPTGATLRLFSGKVVPLERLAKRPGVDEFLRDMAKLYKIVVFTAAMQYYADKILDKLDPDELITHRLYRCVL
The following text describes a protein:
Function:
Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates and activates the ubiquinone biosynthesis protein CAT5/COQ7. Also dephosphorylates CIT1 on 'Ser-462', which leads to its activation.
Subcellular Localization:
Mitochondrion.
Sequence:
MFANVGFRTLRVSRGPLYGSCSQIISFSKRTFYSSAKSGYQSNNSHGDAYSSGSQSGPFTYKTAVAFQPKDRDDLIYQKLKDSIRSPTGEDNYFVTSNNVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAAYAKIRDEKVVKVGGTTAIVAHFPSNGKLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLKEAERRGSKYILNTPRDADEYSFQLKKKDIIILATDGVTDNIATDDIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDPNYPSVFAQEISKLTGKNYSGGKEDDITVVVVRVD
The following text describes a protein:
Function:
Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position. The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
Sequence:
RAATPGPSFWLGNETLKVPLALFVLNRRRLCERLRKNPAVQAGSVVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDIDSGTSTLFVPRLPPSHATWMGKIHSKEHFKEKYAVDDVHYADEIASVLTSRSPSVLLTLRGVNTDSGSVCREASFEGISKFNVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYEMERPCLCSLPGAYPTLFCLPAGLPLKSIFQARTQRLLLSPPCIHPSLSLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQDGDMCLFDMGGEYYCFASDITCSFPANGKFTEDQKAIYEAVLRSCRAVMNSMKPGVWWPDMHRLADRVHLEELTRIGILTGSVDAMVQVHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQAGMVLTVEPGIYFIDHLLDEALADPARACFFNCEVLQRFRGFGGVRIEEDVVVTNSGMELLTCVPRTVEEIEACMAGRDKAFVPFSGPK
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MAGTPSNVIETPTTTLGYWEGARGIVVPIRYMLAYAGVPYRFKTYPFRGGATLAECRAPWLEDRPALAEQGLPFPNLPYLIDGDVQLTQSLAILRYLARKHGLDLPDADPGTAARLDMIEAQVNDFRWSLIYHCLGDKYEALRWNFLENIPRELSRFSQFLGHRRWLMGDRLTHVDFMLYEALDQYALFSEGCLDAEPNLKAYADRFRNLEPIKRFLESGDFKPWPVFLPNAAHLSAKDELPKALKKSG
The following text describes a protein:
Function:
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MDSMPKVRPNQLTRSSIMPVKKKRKSSGSEDPSIRKCKITSYCRTQTSGRLVNPEDHFSNKKCLAWFYEYAGSDDIVGPESMEKFCEDIGVEPENIVMLVLAWKLEATNMGFFTKEEWLKGMTSLHCDGTERLQGKLDYMRSLLNDPVIFKSIYRYAFDFARDKDQRSLDMDTAKSMLALLLGRTWPLFPVFHQFLEQSKYKVMNKDQWYNVLEFSRTVNADLSNYDEDGAWPVMLDEFVDWHKVRNAL
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MCPLITRDLHRIFQKLDKNGDGLLSIGELNWLLEKIGVHFSPEELEGSVGKSSLDFNEFLLFYDSITECSYGAGGEEEEDEVVVEEEEEGSNKELEDLAKAFNVFDINGDGFISSEELQSVLARLGLWDEMSGKDCTSMICAFDTNLDGVLDFEEFKNMMLQTSS
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MQNTLLRTYINSPLEQFEVKTFLGLNTPFIDLSGLNITTFTLYTIIVLLVVSSLYVLSNNNNKIIGSRWLLSQEVIYDTILNMVKGQIKGKDWGYYFPFIYTLFMFILISNLISMIPYSYALTAQFVFIISLSMIIWLGITILSLFKHGWVFFSLFVPSGTALPLVPLLVVIELLSYVARAFSLGLRLSANIFSGHLLMAILAGLTMTFVQINIFTLILGFIPLAIILIIMCLEFGIAIIQAYVFSILASSYLKDGLYLH
The following text describes a protein:
Function:
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
Sequence:
MVRYDITFFSDFDIYLFKEGNHFNAYEKLGSHIIEVDGKKGTYFAVWAPNAERVYVIGDFNGWELSHPLSVRWDNSGIWEGFIPEIDKGTKYKYYIISKYGYHLEKGDPYAFFWEIPPATASIVWDLEYKWNDEEWMKNRVKRNGLNCPISIYEVHLGSWRRVPEQGNRFLTYRELAEWLPKYVKDMGFTHVEFLPVMEHPFYGSWGYQTIGYFAPTSRYGTPQDFMYLIDKLHQNEIGVILDWVPSHFPDDGHGLSFFDGTYLYEHQDPKKGYHPHWHSYIFNHGRNEIRNFLISSAVFWLDKYHIDGLRVDAVASMLYLDYGRAEGEWIPNKYGGKENLEAIEFIKRLNETVYEKYPDTQTIAEESTAWPLVTHPTYIGGLGFGMKWNMGWMHDTLYYFSKDPIYRKYHHGELTFSIWYAFSENFVLPLSHDEVVYGKSSLLNKMPGDQWQKFANLRLLFGYMYAHPGKKLLFMGGEFGQWDEWYHEGSLHWHLLDYPEHQGIQKLVRDLNNLYKTEPALHELDFSPAGFEWIDCSDADQSVVSFLRKAKDPKNVIIVVCNFTPVPRFNYRIGVPFKGYWREILNSDSWIYGGTNHGNTGGVEADQIPCHGRPYSLCLTLPPLGILFLKCQGIV
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MEALDSVDDLWGFLSDIGEDDYDKSRKAFPSVDLDDTNHSFSEFAVEDLEWLSNKDAFPAVETFVDFSCIQPDISQNQKIAPIVENSTSSSNSNNSSNSITLLSGYNHVKFPVRARSKSRSKPRLGISDTWNHQFAWKQPNNKTSKEQAKQTSTIGRQCHHCGADNTPLWRTGPGGPKTLCNACGVRYRSGRLVPEYRPAKSPTFCNNVHSNSHRKVVEIILSKPHLGISDTWNRQFTWKQPSNNTSKEQSKKTSTIGRKCHHCGADNTPQWRVGPDGPKTLCNACGVRYRSGRLVPEYRPANSPTFCSNVHSNSHRKVVEIRKQKRIRIG
The following text describes a protein:
Function:
Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity.
Sequence:
MSFSEFYQRSINEPEAFWAEQARRIDWRQPFTQTLDHSRPPFARWFCGGTTNLCHNAVDRWRDKQPEALALIAVSSETDEERTFTFSQLHDEVNIVAAMLLSLGVQRGDRVLVYMPMIAEAQITLLACARIGAIHSVVFGGFASHSVAARIDDARPALIVSADAGARGGKILPYKKLLDDAIAQAQHQPKHVLLVDRGLAKMAWVDGRDLDFATLRQQHLGASVPVAWLESNETSCILYTSGTTGKPKGVQRDVGGYAVALATSMDTIFGGKAGGVFFCASDIGWVVGHSYIVYAPLLAGMATIVYEGLPTYPDCGVWWKIVEKYQVNRMFSAPTAIRVLKKFPTAQIRNHDLSSLEALYLAGEPLDEPTASWVTETLGVPVIDNYWQTESGWPIMALARALDDRPSRLGSPGVPMYGYNVQLLNEVTGEPCGINEKGMLVIEGPLPPGCIQTIWGDDARFVKTYWSLFNRQVYATFDWGIRDAEGYYFILGRTDDVINIAGHRLGTREIEESISSYPNVAEVAVVGIKDALKGQVAVAFVIPKQSDTLADREAARDEENAIMALVDNQIGHFGRPAHVWFVSQLPKTRSGKMLRRTIQAICEGRDPGDLTTIDDPASLQQIRQAIEE
The following text describes a protein:
Function:
Has an essential role in the initiation of differentiation. Also required for cAMP signaling.
Subcellular Localization:
Endoplasmic reticulum. Vacuole. Note=During late development it changes it's location from endoplasmic reticulum to pre-spore-specific vacuoles.
Sequence:
MKQIIRLITTLLLLSLIGITCAAVAKLHETDKKFKGVELPEKFLDDFNLEVGKLQYANLFRSKKDDITHSAGEIRIDQQGSFSRGEKKKKFKVYNLQAQTNGKSSKTVAHVEVFDTIDAKTKAEQNEVLALAKEAFTKSKDSGKLYQVIPN
The following text describes a protein:
Function:
Major thyroid hormone transport protein in serum.
Subcellular Localization:
Secreted.
Sequence:
MKLLPYLAFFIICIIASHSEVLHDSHQDEDKIAKAQEAIEPANIDFALHFYKHLVTETQAEEKSAPKNLIFSPISILSVFSMLLLGAKSESHQQILNGLSLNQTQVPEEDMHEAFEHLLQVLNRPKSNLKVKIGNAVFVEDALKILDSFTQEIEHHYHAEIFPSHFKNPAEAEKQINDYVSNKTDGKIQELVKDLSEETKLLLINYIVFKAEWEHPFSSHSTYSGKFSVDDNTTVEVQMMYKTDEYIFFKDEKIPCSVLQLPYKNNASMLLIVPELGKIHEVEEALSVETLKRWKSSAEKRFFELHLPKFSISSSLKLKDILTDMGMGIIFTDSADFSGISEKSRLKISKVVHKAVLDVDEKGTEAAAASAAEAVLTSLMETFNIDRPFITLIYSEEPYSILFMSRVIDPTEK
The following text describes a protein:
Function:
Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Also participates in viral entry at the fusion step probably by regulating the core fusion machinery.
Subcellular Localization:
Virion tegument. Virion membrane; Lipid-anchor. Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Domain:
The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16.
Sequence:
MGLSFSGARPCCCRNNVLITDDGEVVSLTAHDFDVVDIESEEEGNFYVPPDMRGVTRAPGRQRLRSSDPPSRHTHRRTPGGACPATQFPPPMSDSE
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MAATLADFKGWQIIVTDESGSVIKDTGRRRRRRGDSKEIVRLQRKSDGLQLSCADSIVCKDPQTNSLSIYMIHEIRLNTASNYVELWCFGYLCWYEINPEEYYAQFLPEALDSCPDSLSSVERADYFREKFQLECNRSELYLTAELSEIYLKDLVSLAQVYDTDSFSPECVTQENQMTTFVVSSACEPDGNNFVAINIREVEDKIRRSDPETSKRYVKELTAITPAPVAKKKVTVQVSQRRRGEQPRREAANLKRVIVKHEEANDGQPCISPAPAKKELSQTIPAPSQDKDSNKEPTPAVAAPIKEQTPTTMASVDVSPKGPTLARKNSDRRAKNKTKEEQPPRRDTRGSIPDLNKRSEKPSRSQNSKAKSFVNSETDEEVSSPSDDHVTEDESDEYISDASTNSIQHRDLEGGLGKRGRNKENEEEADGAERRSSRARKGTSGPQKRKASRSPTKESRLATPKRAITKKNVSRAKKAYTPFSKLYKDPGEIPDLNKNKDFYRENHDWDISALENHFRSPTKQKSVETIFSKVKRQLNSTHSKEEIVKASNFEDYLPARENEFATIYLSMYSAIEAGTGTSIYIAGTPGVGKTLTVREVVKELLISSDRKELPQFQYIEINGLKMVKASDSYEVLWKKISGSTLTSGAAMESLEYYFKEVPQTKKRPVVVLLDELDALVTKNQDVMYNFFNWTTYENSKFVVVAVANTMDLPERQLGNKVSSRIGFTRIMFTGYTHEELKTIINLRLMDLNDSHFYVDPETGNSYLIQDGDTTQLPKDVSKLQKVRLKISEDAVEIASRKIASVSGDARRALKVCKRAVEIAEQDYMEKHGYAFDGQAQQRTSAFQPTSEELQKVEIHHITKALQETITSPTDTYLRRMSFTSKLFLYALVNLIKKSGAHEQTLGDIVDEIRLLLEVNGKNKYILEMKRVLFVGDNDEEENEQLRIISWDYLIDQLVETGIIIKQNLKNERMCAIKLNISFEEVCRNIMEDEVLKTL
The following text describes a protein:
Function:
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
Subcellular Localization:
Cytoplasm.
Domain:
The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
Sequence:
MAAFSLGDLHINEAGWGPEGGPKKFEGIPYQPFRKTDRIATAADFVSSMGPRAARTNRIYGDGEAFAYYHDDDSSFRLVDTAKARPTFRTQKKWQNKNRRHVRTDPNRGVQQLAYNKNRERDRRALERKLQKKWGQTAQRRFDRNISRKLEASLDVRPSWELLEDIEFAKFAKFKTAIPEVSDYKKAGELYFLDQAKEKTVPKRPVEVPPDFTGEYDPFSVPASEDPVLQKIDRIGRANVFATDDVLATFMAATRSHYSWDIVATKKDGKIYFDKRPGAVIDMLSVDETAFQPPSDEGDSPNAPGNLSVEATHVNQMFKDFAVNKSGPKKEMKSAHDFKEEADMSVAYRYRVWDLGSGIQLAARTQHDAMATGKDGKSEYCSVNTLLERVGKGTTLDWRTVLASQKTAVLASQLKDNAFKLARWTICSLLGNNSTMRLGYVSRANPASPRKHVLLKVDSFRTEKFAEQIGVNMANGWGIVKSMIVRLQKHGDGQYVLMKDPGEPMLKMYRLPEEGLAEGIEDDGTEDGQSSSMAAGIFGGSANM