lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination. The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction. In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low. Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols. Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation. Required for proper lipid homeostasis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Palmitoylation promotes localization to the peripheral endoplasmic reticulum.
Domain:
The CUE domain is required for recognition of misfolded proteins such as mutant CFTR; The VCP/p97-interacting motif (VIM) is sufficient for binding VCP/p97 to form a complex capable of transferring VCP/p97 from the cytosol to microsomes.
Sequence:
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
The following text describes a protein:
Function:
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGMRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSVRSVRLVRDKETDKFKGFCYVEFDEVESLKEALTYDGALLGDRALRVDIAEGRKQDKGGFGFRKGGPDDRGMGGPRDSRGGGGWDSRDDFGSGFKDDFLGGRGGGSRPGDRRPGGPPMGSRFRDGPPLRGSSMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFFKLLREALKVKQVRSKILFTIFIVLVFRIGTSITVPGVNANSLNALSGLSFLNMLSLVSGNALKNFSIFALGVSPYITASIVVQLLQMDILPKFVEWGKQGEVGRRKLNQATRYIALVLAFVQSIGITAGFNTLAGAQLIKTALTPQVFLTIGIILTAGSMIVTWLGEQITDKGYGNGVSMIIFAGIVSSIPEMIQGIYVDYFVNVPSSRITSSIIFVIILIITVLLIIYFTTYVQQAEYKIPIQYTKVAQGAPSSSYLPLKVNPAGVIPVIFASSITAAPAAILQFLSATGHDWAWVRVAQEMLATTSPTGIAMYALLIILFTFFYTFVQINPEKAAESLQKSGAYIHGVRPGKGTEEYMSKLLRRLATVGSLFLGVISILPIAAKDVFGLSDVVAFGGTSLLIIISTGIEGIKQLEGYLLKRKYVGFMDRTE
The following text describes a protein:
Function:
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis.
Subcellular Localization:
Nucleus. Chromosome. Note=Colocalizes to nuclear foci with RPA1 following DNA damage. Localizes to double-stranded DNA breaks. Recruited to chromatin by MSH2.
Sequence:
MNSDQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPVVVNAMTLFETNMEIGEYFNAFPNEVLTIFDNALRRSALTILQSLSQPEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKILEFERDYMCNKCKHVFVVQADFEQYYTFFRPSSCPSLENCDSSKFTCLSDLSSPTRCRDYQEIKIQEQVQRLSVGSIPRSMQVILEDDLVDSCKSGDDITIYGVVMQRWKPFKQDVRCEVEIVLKANYIQVNNEESAGVNMDEEVRKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPRESVSVNIALSSPLLSRFDLILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKSYFCLIRKLQPTLSDEGNQVLLRYYQMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAVTVVSVMESSMQGGALLGGVNALHTSFPENPLQQYQTQCELILEKLELPNLLSEELRRLERLQNWSVDQSQPQAMEAETIPGSLGGDARKESNFRTSTQQEVNCSAHRFSIGGSFGGSPLLGPSSHLGPKGPASGKHSEEHRNSQDGSLDWFDSVATHPIEPKNTAPVSPSPKTSRGAMALKICNNRSQGKEDREAGQRSKLETEPLPAAGETETPLRPGNREGERPRKAATVSEAAVSADEPDSVLTHHVPRKLHKLHKARAQELCRNPTRPPLQPTSPSHPQPTPIQSPERVLETPKRKRQKSHAQAQEPHQESVESLGAPVAKLAKFTFKQKSKLTHSPEDRGPVSPGTSKPVVQSPENPQRRAKRGAALPGKGPEKLASRIRSSAQPQDETRGVSPQPPYKDRPEEKRERAPAKGTVQPELELGNDMGRFFLASERVRKEEVSCSNKSSKVHACTLAKLANFSFTSPSESKSESPPPPQSKNPSEGGPSCVATATALGRKRKTFQLDTSTEKLSLSKTSLFTLPELDDEPLDFDWDEEMRKKP
The following text describes a protein:
Function:
Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). May otherwise add the first alpha-1,6-mannose to the Man(8)GlcNAc(2) core oligosaccharide from the ER. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Is recycled between the trans-Golgi network and a late compartment of the endoplasmic reticulum.
Domain:
The conserved DXD motif is involved in enzyme activity.
Sequence:
MLRLRLRSIVIGAAIAGSILLLFNHGSIEGMEDLTEISMLEDYTPEAANKDYVGQQEEEELLYDQPSYIEEEEDPDLEAYLSDLEREELEHSLEELDEENNYKLHLRYSFSQLQDFDEENEAVHMIVPKDTYEFEVPYHADIPKLIWQTSKDPFDREVMKYTRFWRINHPSYSHAVLDDEQSKALVISSFGDSSVSKISQAYAMMPLPVLKADFFRYLVLLAKGGIYSDIDTAPLKHINNWIPREYRKRNIRLIVGIEADPDRPDWNDYYARRVQFCQWTIAAAPGHPILWELVRRITDETWKLHDSKKLSKNGESVMEWTGPGIWTDAIMDYLNWQYGPFSVENITNLEEPYLVGDVLILPITAFSPGVGHMGSKSPNDPMAYVQHFFAGSWKDD
The following text describes a protein:
Function:
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MSEKDGDLGRPTEDGLPSPIDYPAAEGTAEMVATPEADAADSENLITGPRMLSLMSTSSTPDNEQVPLKNYTGKEPPFTCSPSQGLTFIIVGWVSLAVVITVALIIQIYVGPPQVVPHGAVVSDAALCSDIGADILKNEGSAVDAAIATVLCQGVVNPQVSGIGGGGFMVVRLRDKSASVIDFRETAPSAATRDMFHNKLSQVNVDGLAVAVPSQLRGLELAHQKYGKLPWSRVISPVVELARSGFAVTEELADALSSIGIDNMSGDFKKVFAPNDRLFTAGQKMTRSDLADTLEQVAENGADVFYTGPIAESVVTAAHNTGGVINVQDLTDYQALLKPTLNTTYKGSYILTAPAPSGGPSLLSILNIMEGYNMTGKDANKAVTYQRLVEAFKFGYAQHTTLGDPDKAPNVTGIVNRIVSKAEAKKLRGKIDDSQAYTSPDHYGPFYTLGDDKGASHVSVIGPDLDMVSVTSSLHDLFGSGVITSTGVILNGHMADFSIPGQASQTGAPNPENYIVPGKRPLSWLSPTIVVPVSNPCGKHLALGASSGTTTLSGVAQVVLNILAFDKELEISVEGPRLHNQLQPDETRAEAGFSADILTQLATWKQNVVRDQEALNVVQAAYRVKDAITGQADTREKGSKASVF
The following text describes a protein:
Function:
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in the formation or maintenance of synaptic junctions via its interactions (via the extracellular domains) with neurexin family members. Plays a role in synaptic signal transmission.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane. Note=Detected at glycinergic postsynapses in retina. Detected on dendritic spines on cultured neurons.
Sequence:
MPAPVPALLCLALALASAQPSPPPPPPFPVVATNYGKLRGVRAALPGDVLGPVTQFLGVPYAAPPTGERRFQPPEPPSSWAGVRDATRFAPVCPQHLDERALLRDCLPAWFAANLDAIAAYVQDQSEDCLYLNLYVPGGANGKKMADDVTGNDHGDDQDSRDPGVGGAAAAAARKPVMVYIHGGSYMEGTANIVDGSVLASYGDVIVVTVNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWVEENAGAFGGDPDRVTVFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPARYARALGERVGCATPDPGSPPGSPPGWDSASLVSCLRGKAAGELARARVTPATYHVAFGPTVDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGARFVDGLGGGHDGGYGGYGGGYGGGVEDDEVQDGGPDGAAGGVSAGEFDLAVSGFINDLYGRPEGRGDALRETVKFMYTDWADRDSPEARRKTLVALFTDHQWVAPAVATADLHARYGSPTYFYAFYHRCHGGGGGGGGVDGVAGGVAGGVGGEEARPAWADAAHGDEVPYVFGVHMAGPGDVFGCNFSRNDVMLSAVVMTYWTNFAKTGDPNQPVAQDTRFVHTRPNRFEEVAWAKYDPRGQLYLHIGLRPRVRDHYRAAKVAFWLELVPHLHGLAADPGAYLSAAATRAAPSGDPDRDPGGGGGGRRRPRPATRRPAVMTSSSMASGSGMTSSSGSGMTSSSGSSASAVLIETRRDYSTELSVTIAVGASLLFLNVLAFAALYYKKDKRRHETHRRPPPPRPPQAPPSAAAADRNPRPDPGPAGRRGGECGAVVTAMAAEASAGGLGHDGVGGVGVGGVIGGVAGLRLACPPDYALTLRRSPDDVPRAGAGPGTMTLIPGALGGGGGGAVHGFNTFGSGVGVAGVAGVATSQAGPGLPHGHSTTRV
The following text describes a protein:
Function:
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Subcellular Localization:
Cytoplasm.
Sequence:
MADDYLVRIGRLIRDARQHRGWTQSQLAEALNTSQSAVNRIERGNQNISLEMIARIGEALDSEIVSLGYAGPMHLRVVGGRRLSGAIDVKTSKNACVALLCASLLNKGRTVLRRVARIEEVYRLLEVLNSIGVRTRWINDGTDLEIVPPAELDMEAIDAEAAVRTRSIIMFLGPLLHRMERFRLPYAGGCDLGTRTIEPHMIALRRFGLDVAATEGHYHAVVDRQVRPDRPIVLTERGDTVTENALLAAARHDGVTVIRNASSNYMVQDLCFFLEALGVRVEGIGTTTLTVHGMPVIDADVDYSPSEDPVEAMSLLAAAVVTESELTVRRVPIEFLEIELAVLEEMGLDHDRTPEYFADNGRTRLVDLTVRPSKLEAPIDKIHPMPFPGLNIDNVPFFAAIAASAQGQTLIHDWVYDNRAIYLTDLNRLGGRLQLLDPHRVLVEGPTRWRAAEMMCPPALRPAVVVLLAMMAAEGTSVLRNVYVINRGYEDLAERLNSIGAQIEIFRDI
The following text describes a protein:
Function:
Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Prefers short-chain length polyphosphates as substrates. Can also hydrolyze ATP and ADP substrates, but lacks GTPase activity. Cannot hydrolyze pppGpp to ppGpp.
Sequence:
MRLGVLDVGSNTVHLLVVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTIDEFAKIAISSGCAELMAFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFLAVRRWYGWSAGRILNLDIGGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGRRRVAMLRDWLDAELAEPSVTVLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRTLTANGLRQLIAFISRMTAVDRAELEGVSADRAPQIVAGALVAEASMRALSIEAVEICPWALREGLILRKLDSEADGTALIESSSVHTSVRAVGGQPADRNAANRSRGSKP
The following text describes a protein:
Function:
Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPMVKRQLTERYEPGNEAQDADDGFVPPFVNIVPPDSDEDKNSSSNSLPIRRIRKRGPYEDSDEGDYSDNDDDFEERVEYSPRRLEGTFGDDGELDGISEHDHSHRDDMISNTDTAHSDRVSSLGMSSKAESPSKKWEPRIANLFKSALGNNNAKQKPQLSLRTTSLSTNTQDKARKYSSSDEPGSPSAKSAVSFHSSGVRSNVLHRSNKSGESSPRRRSISTDGPPRSAKVLSIIDADDMDEFEDMKRGFQSAIEDKKFAWLPQLQQETESADELEAGDKSKLNIDIKSTLTPRGRSGSQFRNDSTEDLHFEPGLFSSPSKHSSRRPSIIASSIAHGLGINLEKDKNVDTVSIEVELPDFDEYENAKKRPPLILHGNSLGYFGPNNPLRYKVAHILLNKYYKIAHILLLTFLTALLAYRSYEPENFDFLYRFRNWSDYIIFILFILFTSNDIAKIFAFGFWDDSQMFAYHQLEYISLLERFGITKLYHLIKKKYGPKIVHFLLPFNVISDESEKETIQRNMKANISAKNDTNSKSLKFNCPRAFCRSSWNRIDLLSSVCFWLGMFLSINNYDKRVGIRIFKPLAAMRILRLVNTDTGITSILRGLKYGMPQLINVGSMLVYFWVFFGILGVQIFKGSFRRQCVWYNPENPNDRYQYQLQFCGGYLEPVTKKKMNYIFEDGREGPVSKGFMCPQYSKCVSSSNPFNGRVSFDNIINSMELVFIVMSANTFSDIMYYTMNSDEFSACLFFIISIFVLTIWMMNLLIAALVSSFQLAHEEFKKKKLEESSNESWPIRFALGYWRYFKVKASQTEFPSWAERGLKYYEKIEPVFIILIMFDLIMRCLIKDTSSQHFVTTLLRIDRGVTIVLFIESIFRLVLHIPNMWKFLTRFNYVYDLFVAILTLVITILANAGLLGHGYYWLSFFQITRFYRLVIYIGFTRKLWKEVLGNGIMIWNLTAFYFFFTFLASIILSLYFEGVIPQDQIEDQLLGMYSLPNSFLSLYSIGSTENWTSILYIIQQYSPNISSAFFSTVFLIIWFILSNSVILNIFIALISESLEVKEDDKRPMQIKHYLKHIYPQKIQRFRHASLLARIKKKIFRTDSQEDSRDFKQFLMRGTAIMNIAQNLGDLSKEFNTEQDRDIVTLLVRLTEYIPILRKFGIYSNNPFYKRNEIMFSETSDLNGRNYMLQLNEFEDEKLDYLQKHSMFNYSYYLFSPRHRFRKFCQKLVPPSYGKRTDNYKFYEDDTDTYSRKTYFNHIWRDLFVVFYAAATVLLIVFSCYVTPIYRMKRNMSSKNWVTYVDAAFLAIFCVEFIIKTVADGFIYTPNAYARNPWNLIDFFVLISMWINLIAFLRNDGNLSRVFKGLTALRALRCLTISNTARETFKVVLFNGIGKILEAGLLSLTLLFPFTVWGLNLFRGRLGVCNDGDLGRDECFNEFSNEVFQWNVMMPRVYDNPELYLDSFTSAFNSLFQIISLEGWTDLLGNLMNSTGVGKPASLLASTGNAVFIIAFNFLSIVFILNLFVSFIVNNQAKSTGSAYFTSEEKAWLESQKLLSQAKPIAIPTFHDISRVRIFLYNIAVEKNNIYYAIFLQTVTYIHIIMLLSLTYKDHGSGLLYSQVYFMFSTTVFLLQELFHVYGAGLRIYKMNKWNLIRIQILIVSFLLTLISFNVDRAYIWYHNVNGFFHLVIFLFIIPQNDTLSELIETAMASLPPILSLTYTWFILFLVYAIALNQIFGLTRLGPNTTDNINFRTVLKALIVLFRCSFGEGWNYIMDDLKVKEPYCSQRVKGNYSDCGSQTYAYILLISWNILSMYIFLNMFISLIIGNFSYVYRKGGTKSEVNRGEIRKYVETWARFDPDGTGKLDFEYLPKIMHSFNGPLSFKIWEGKLTVKNLVKNYMEVNPNDPYDVKVDLEGLNKELDSINMESIMNRRLQYRRFVQEVYYTQAYMGYMKFSTLLDLVPLYTTYDPRECLGIDQYVRHLYIMGKVDRYLDNERNVDVLDMVVTRWKHHLKRKYGPNYKLDQDSIKKDLNIKVPEIKTWNESVESVTTPRVSYGVNDFIWSPRNNSNSSAYSKPLPQSHARPIPPHIQISNSRVMEYTNRDSLSSLENIHNQSDEELKDPFRDI
The following text describes a protein:
Function:
Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Synaptic cleft. Presynaptic active zone. Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals.
Sequence:
MDLISTFLLHFLLLACSLPPGAVSLRTALRKSGKVGPPLDIKLGALNCTAFSIQWKTPKRSGSSIVGYTVFYSELGSDKSLREQSHNVPVGQDTLITEEVIGDLKPGTEYRVSIAAYSQTGKGRLSFPRHVTTLSQDSCLPPEAPHQPHVLVVSDSEVALSWRPGENEGSAPIQSYSVEFIRPDFDKSWTIIQERLQMDSMVIKGLDPDTNYQFAVRAMNAYGFSLRSQPSNTIRTLGPGEAGSGRYGPGYITDTGVSEDDDASEDELDLDVSFEEVKPLPATKVGNKKSKKTSVSNSEMDSRLAQPTSASLPETTVAVPPTPAQRKGKNSVAVMSRLFDMSCDETLCSADSFCVNDYAWGGSRCHCNLGKGGEACSEDIFIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGESEHGRGDFMSLALIRRSLHFRFNCGTGMAIIISETKIKLGAWHSVTLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGKKIDMRPWPLGKALNGADVGECSSGICDEASCINGGTCAAIKADSYICLCPLGFRGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFTEFEITFRPDSGDGVLLYSYDTSSKDFLSIIMAAGHVEFRFDCGSGTGVLRSEDTLTLGQWHDLRVSRTAKNGILQVDKQKVVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGILHPFSGSIQKIILNDRTIHVRHDFTSGVNVENAAHPCVGAPCAHGGSCRPRKEGYECDCPLGFEGLNCQKAITEAIEIPQFIGRSYLTYDNPNILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFSDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALRTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MLELMKGDFDEDENGIGLSLSLSIGGNYTKKNDQVFNSDDKMLIEWQRSKKRVLHREMMENEELIWRKSKISTSGSEGVKSLNLFMNQDSCVNDHNLVVPICDHRNVGKRESMRKNCRGFRIYNSNTSYNQCRSSESNGSMERCSSTITKCQSSSPKGRSSSNVMSIKEEQDQKTEEKRNCGMIQLLSRMPCVSATGNGPNGKTINGLLCKYDNKMEINIVCVCHGKSFSPSQFVEHAGAVDLSQPLKHITVIPPCF
The following text describes a protein:
Function:
Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes the second stereospecific hydrolysis reaction (deamination) of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S-ureidoglycine.
Subcellular Localization:
Cytoplasm.
Sequence:
MGYLNNVTGYREDLLANRAIVKHGNFALLTPDGLVKNIIPGFENCDATILSTPKLGASFVDYLVTLHQNGGNQQGFGGEGIETFLYVISGNITAKAEGKTFALSEGGYLYCPPGSLMTFVNAQAEDSQIFLYKRRYVPVEGYAPWLVSGNASELERIHYEGMDDVILLDFLPKELGFDMNMHILSFAPGASHGYIETHVQEHGAYILSGQGVYNLDNNWIPVKKGDYIFMGAYSLQAGYGVGRGEAFSYIYSKDCNRDVEI
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MKGYNTRSSSRRAQDKPVGLYPGLNDLTDALEALPLETVRHFTLLREIDAKCTTTTPLVADLIAKFLAIPPAAKDDPECAKKTEERENMLLEIRGLIRELMPCLEEKMHVAGVAAEAVARHISRIDADYELITSREIPQVIQYGEPDHPAIIVDVKPSVAERSAQSQRSESRREAIAAKKAAAAAAAEKSGNGGRRGTPSKEGGKDSGKETGGKKAAATNGAAAVGAGAKKNGEKRTATSASVSDTVASSAAAAGAKKRKTAAKASPAPGNRKSPPSSDDTPAASATRSARLVNKSRKGQEAAESAKAAEEEEDDGEPVYCYCEQVSYGEMVACDGPQCTREWFHLPCLGLSSPPKGNWYCDECKQGRKR
The following text describes a protein:
Function:
Maternally provided pie-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex. Acts redundantly with gei-17 to promote piRNA-mediated silencing and fertility in adult germline. Promotes the sumoylation of hda-1 in adult animals but not in embryos thereby regulating its interaction with mep-1.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasmic granule. Note=Initially associates with both centrosomes of the mitotic spindle. Rapidly disappears from the centrosome destined for the somatic daughter and persists in the centrosome of the daughter that becomes the next germline blastomere. Accumulates in larger cytoplasmic granules (P granules), which are visible around the nuclei in the micrographs.
Domain:
The C3H1-type 1 domain is required for degradation in somatic blastomeres; The C3H1-type 2 domain targets the protein to P granules, is involved in germ cell positioning in embryos and is required for default nos-2 expression.
Sequence:
MAQTKPIAEQMAALNNSDDTSFAADRSNSLLNATCPARIQNSVDQRKINRSFNDSLSSGYSGKWLRPKREALKITPLAQIDEAPATKRHSSAKDKHTEYKTRLCDAFRREGYCPYNDNCTYAHGQDELRVPRRRQEYYSRDPPRERRDSRSRRDDVDTTINRSSSSASKHHDENRRPSNNHGSSNRRQICHNFERGNCRYGPRCRFIHVEQMQHFNANATVYAPPSSDCPPPIAYYHHHPQHQQQFLPFPMPYFLAPPPQAQQGAPFPVQYIPQQHDLMNSQPMYAPMAPTYYYQPINSNGMPMMDVTIDPNATGGAFEVFPDGFFSQPPPTIIS
The following text describes a protein:
Function:
Involved in auxin signal transduction and cell expansion and proliferation regulation. May be involved in brassinosteroid-mediated plant growth and development via auxin regulation. May be involved in microspore and pollen development.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The leucine-rich repeat (LRR) domain is disrupted by a non-LRR region, resulting in the formation of two LRR solenoid structures shaped like the Arabic number '7'. This is strikingly different from the horseshoe structures of the canonical LRR proteins.
Sequence:
MEAPTPLLLLVLLTTITFFTTSVADDQTAMLALAKSFNPPPSDWSSTTDFCKWSGVRCTGGRVTTISLADKSLTGFIAPEISTLSELKSVSIQRNKLSGTIPSFAKLSSLQEIYMDENNFVGVETGAFAGLTSLQILSLSDNNNITTWSFPSELVDSTSLTTIYLDNTNIAGVLPDIFDSLASLQNLRLSYNNITGVLPPSLGKSSIQNLWINNQDLGMSGTIEVLSSMTSLSQAWLHKNHFFGPIPDLSKSENLFDLQLRDNDLTGIVPPTLLTLASLKNISLDNNKFQGPLPLFSPEVKVTIDHNVFCTTKAGQSCSPQVMTLLAVAGGLGYPSMLAESWQGDDACSGWAYVSCDSAGKNVVTLNLGKHGFTGFISPAIANLTSLKSLYLNGNDLTGVIPKELTFMTSLQLIDVSNNNLRGEIPKFPATVKFSYKPGNALLGTNGGDGSSPGTGGASGGPGGSSGGGGSKVGVIVGVIVAVLVFLAILGFVVYKFVMKRKYGRFNRTDPEKVGKILVSDAVSNGGSGNGGYANGHGANNFNALNSPSSGDNSDRFLLEGGSVTIPMEVLRQVTNNFSEDNILGRGGFGVVYAGELHDGTKTAVKRMECAAMGNKGMSEFQAEIAVLTKVRHRHLVALLGYCVNGNERLLVYEYMPQGNLGQHLFEWSELGYSPLTWKQRVSIALDVARGVEYLHSLAQQSFIHRDLKPSNILLGDDMRAKVADFGLVKNAPDGKYSVETRLAGTFGYLAPEYAATGRVTTKVDVYAFGVVLMEILTGRKALDDSLPDERSHLVTWFRRILINKENIPKALDQTLEADEETMESIYRVAELAGHCTAREPQQRPDMGHAVNVLGPLVEKWKPSCQEEEESFGIDVNMSLPQALQRWQNEGTSSSTMFHGDFSYSQTQSSIPPKASGFPNTFDSADGR
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Sequence:
MGMRRATLGLLKSGLRDGSDALRSLSTSTALSQAAASGATNGSRDFMGWLKGGAARVTTPLSQPLPGVQPEQPAFRPLAPPPTEVTVLENGVRIISEASPGPTASLGMYINSGSIYENASNSGCSALLECLGFKATQHRNTLRIMKEVEKFGNTIVANASREQMSYTIDCLKTGFPAALELLLDCVLNPAFEEGEVEDQKARLAALLGGKDIHATLMTELMARSAYRGPYGNPLIPDPEAMAGITPDTLRAFTARTYIAPHMVLAAAGVEHKALVELAAPMLAGLPKLPPLPEPKPDYIGGAVHLPGAYPQANLLLAFEYKGGWRDVHGAVVMTVLNYLLGGGNSFSSGGPGKGMHSRLYTRVLNKYAWVHSCASFNTTFNESGLVGIQASCDPPHVHDMLHVMCHELESVENGTNRIELERAKRAAVSVICNALESKATSAEDIGRQYLTYGHRISGRTYVEMLEAVTADDVRKFVQQLLRSKPSLAAYGDNTQSLDPSVLARRYG
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MPCYRFYLNSNLVKNGRVALQGDQLHHMKNVMRLRVGETVEIINGRNQLAQARIDAYQGNQIAHVNIDQVLTQLVLDKPRINLIQPLIRSKGLDLVIEKCTELGVSHFYLYASELGEISQFSSARCKKLTEIAISAIKQCGRLDLPTLTFADRLHNLKLQSNVHPICFGDTRHLDNAQVGFTPQSTLAQCKTVCIGPEKGFSDKEINYLENQLGATGIKISPFILRSETASITLTALTSYASILKQ
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MASPWLSSREEFSHSRSSSNHSMDDDELMGERQPLLDGMRTAAALSPSTGRSSDLLRRSFHHGGHQRRQCTDVFFLGCLATYWIGMVALAITAFSHESNVGFAQEISSGVDFRGHPCGQHRFVYFPDVDANPDFGICVHECPHKDGELLTVQLPLESGKKSVNGSRELQQVQFVSYATRRWAYVCAPAEVKSEQVMIRQLQDTLGRFVGALGDCWQVLIIASGVSLSTAALYLVLLRYCGCVSVLLSTVSIESTLAYSSYRLLNAASDPLSYANDPVTMGSLQISAVAMCCAAILFLLFAVVNMSRLLLAGAFITHASRALSQLKRLLVLPFISYVLLLLLFGWGILVTVCIFGAGETSTRIATISASSPSSIRVVTESFQVSTKLRWLFIYHIWGMYWSVNFLLSISEMVTATAMSLWYFSPENRVTGLKDFEEADPVSYSMNTTVKYHLGTLALSSGSVAPVEHIRAFFLYLENKNEFDANALTEFAAKCCCCCIWCFKLCLKYICKEAVYVTAIQGTAFYTSGKLAYTLISSNLLRVGALSRIGNASVLLGKLIVCITACLISWFLLEDVPSPVLPLVVVVLFSYSVAHAFMTIYETSINMLLMCFTLDENLHGGRGNSAHASAPLIRSVNDHLRPKWQTVL
The following text describes a protein:
Function:
Involved in preservation of envelope integrity and tolerance to surface stress. Reverses the inhibitory effect of PspA on ClgR activity. Facilitates intracellular growth of M.tuberculosis.
Sequence:
MLVDELGVKIVHAQHVPAPYLVQRMREIHERDENRQRHAQVDVQRRRDQPERGQHQHRRNRDADHHPDGRTLAGQIVAHPVSHRVRQPRPVAIADVLPRVGPRADCVVAHSLQGSPRRRERRRGQTAHQRLGRRSGNAIACPLYLENAAGPEPDTKRAEGRRFGAFGGGDLRWMADRVPRQGSGRRGLGSRSGAGVPQGADARGWRHTADGVPRVGQPAIRRGVPGFWCWLDHVLTGFGGRNAICAIEDGVEPRVAWWALCTDFDVPRSMGRRTPGG