lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Miscellaneous:
MISCELLANEOUS: Present with 2180 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MKLPVAQYSAPDGVEKSFAPIRDDPRYMTTEGRTTGPSDHVLNAGQIDRDKPSEPERTKDGSQLTYLGQLRTQLTGLQDDINEFLTGRMELAKNKKKAGADEKRIQEEINQLLDGGDGDEDAV
The following text describes a protein:
Function:
Probable serine protease inhibitor.
Subcellular Localization:
Secreted.
Sequence:
MKLVGGLLLLFAATYVCNCSEVTSHPSATVDCDIYKKYPVVAIPCPIVNIPVCGSDYITYGNKCKLCTEILRSNGKIQFLHEGHC
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Subcellular Localization:
Cytoplasm.
Sequence:
MMVHSPLATGPHPTTHLEPTMHQPHRSLLRKAFQMIPPLDGSLHKGQAGRIGIVGGSKDYTGAPFYSGYASLRLGSDLSHVICEPSASTVIKTYSPDLMVHSYLSSPKEPEAYASHQNQFEQLLDRLHVLVVGPGLGRDTEMQDWAEWTLKTAIQKKLHLVLDADALWLLVKKPDLLRGYPNAILTPNHVEFQRLLKACSIEPREHDDDGLLAMELSKALGGCSILQKGSIDLVAREGSEVAKVSCEGSPKRCGGQGDILSGLVGTWCAWTKLYFERQSQDEKPKSHELPISPEEAWIIAAVLGSEITRTCSRLAYHKFGRSMQSSDMLGYIGEAFEQVMHGHTKD
The following text describes a protein:
Function:
Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway.
Subcellular Localization:
Secreted.
Sequence:
MRQRAWLPSVSSRPCPFLLLLLLLVVPRVAQPQAGRNHTEPPGPNVTATRMTPMIPATSGNFSTSIGSDPEGEAETEGPQSERYLLSSSSSPLGGQVLTESGQPCRFPFRYGGRMLHSCSSEGSAYRKWCATTHNYDRDRAWGYCAEATLPVEGPAVLDPCASGPCLNGGTCSSTQDHVSYHCACPLAFTGKDCGTEKCFDETRYEYFEVGDHWARVSEGHVEQCSCIEGQARCEDTHHTACLSSPCLNGGTCHLIVGTGTSICACPLGYAGRFCNIVPTERCFLGNGTEYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDKDERPWCYVVKDSALSWEYCRLAACESLARVHSRIPEVLATLPESTSTARPTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGNGFCAGSLVHTCWVVSAAHCFSSSPPRDSITVVLGQHFFNRTTDVTQTFAIEKYVPYTLYSVFNPNDHDLVLIRLKKKGERCAVRSQFVQPICLPEAGSSFPTGHKCQIAGWGHMDENVSGYSNSLLEALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLVCEKNGVAYLYGIISWGDGCGRLNKPGVYTRVSNYVDWINDRIRPPKRPAAAS
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Sequence:
MARTGFCDSKPLLDLHKKADERRVPLRARANACAPTDRRQPAETDESRMAPVKMETESRWERRLSAQTNESIILGFHVDSRASSAETVADECVEKPVLLYPHGLQGLHSLDALVPSLLRHEVEMALEKLDLICDRTFAWDLFLDMMRTQTQNSFPNADLPRHFTDSTRAILVDWMVQVHELLHFQEDTLYLAIHLLNHSLRQLKVTTANLQLLGMVCLLIAAKKEESLLPEVSDLCSLMDHAYTKRQLLRMERRLLCALKFDLSHSPPLHFLLLFAAVARCSAMMVWMARYLLELSLQEAQCVVFLPAQLAGAALCLARHVLQESPTPEGEAAWCLTSSIHVGSQTILLRIMQILATAASRVQTHENSATFIKFSSPERMHVSRHPGLRNPAGLLGVCSSQAPLKGTKLHL
The following text describes a protein:
Function:
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
QCPLCMEPLEIDDVNFYPCTCGYQICRFCWHRIRTDENGLCPACRKAYSEDPAVYTPLSQDEIQSIIRERKHKDTQRKQKLTENRKHLANVRVVQKNLVFVVGLTQRLADPELLKKPEYFGKFGKIHKIVINNSTNYAGPQGPSASAYITFNKEEDACRAILAVSNAYLDGRTLKTSLGTTKYCSYFLRNIPCPKPDCMYLHEFGDEAASFTKEAMQVGKHQEYEQQLLANYAKKM
The following text describes a protein:
Function:
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence:
MDIDELTRRREERRKRREEERLAAQASMAEEEDALEAARRERRERRRRERELEEKGGSRELEVAPRSTRRSRDILSSKDSSVDTESSPRKSRDSPGPGENGETDYLSRRRRSRDLLEDSSTREITRRSRDRDTDDYTSSRRRRSIDEEATTSRRRSRDLGSKDTEEPSFRRRSREILDAQDDDVPSYRRRSRELLDNDDETSSRKSRENTNDEEPSYRRRSREILDADEKKAPEESTFRRRRSREILDTKENEEPDPVEEEAPRRGRKFPGREDRKEVKREPEPEPEPEPEPEPEPEPEPEVEPEPEPEPEPEPEPEPEPPAMEKEEEDHGKVNGVMDHPKENGVNGQHEGGEEDVEEEEEGVVRKEKPQWASMQLKKTKKSVSEEMNEEEASQPKAAPSWSTNQLKSVRKTIIDTEQPPSDPGKPAWAQVKLREVKESRPDPITEINQKREDKSSGYEAERVAEEIRKRREEEEAERMQDFRKQREKEEQELQELKERRDKRRKEREEREAKMAEERAKKAAIEEEERKRRQEEGERRRQAEAERRKQRLNESETPAWINMKLKTVEGGIDKKDPRQKELREAEKRRVLAERRIKLELDGLDAEELSEKAAELHDHLSGVVTAKFDLDSKMQRQEYDINELSQRLREMMGKGNKQAINVEGVDRKFEQWNKMGDSKVQKLAGKKEIVVTGVSDRRKMWEHINDKKEEDEEPPKLISPKKSEISSDDLANRKNLFEQAATT
The following text describes a protein:
Function:
Exhibits phosphohistidine phosphatase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAAAAELQRVVDVEIDDGGVFKYVLLRVRPRAAGASEPGKEVVRGHGWAEYHADIYDRAAAELEPQGFDCECLGGGRISHQSREKKIHVYGYSVVSGAAVPRKRPPGESRVRHRGAEVPGCEGGCGRAAPLRGGWQPRGLVSCWLCGIRTWLFLPGNCSCGSACAGPSARHRAAVGGCMQTAAEWLLCCAGGACRSCNPTLLLFHPTSQCSPPSLPVPISRGYSHWCVALHSDGGCAAWQPSPG
The following text describes a protein:
Function:
Substrate-binding (S) component of an energy-coupling factor (ECF) ABC-transporter complex. Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSSIKKISFVGIFSALATLVMFLEFPIFPQASFLKYDPSEIPALIVSFLLGPGVGMFVVLVKDILFFLMKSGDPVGIAMNAVLGMSFVGIAGLIYHRNKSRATAIKGMIVATLFATAFALGLNALIVPLYFEAPFELYLKFFPFILAFNLVKFGIDSVVTFFVYKKVSSILKLETVEGRSNNG
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MVIIQQQQQQQEEEIIRSDQRGKKGMRIGKYEFGRTLGQGNFGKVKYAKHIDSGKSFAIKILEKHRIHDLRITDQIKREIRTLKVLKHPNVVRLYEVLASKTKIYMVLEYVNGGELFDRIASKGKLSESQGRKLFQQLIDGVSYCHDKGVFHRDLKLENVLIDGGRNIKITDFGLSALPQHLRDDGLLHTTCGSPNYVAPEVLSNRGYDGATSDTWSCGVILYVILTGFLPFDDRNLAVLYHKREGSLGVTYKDVASQVRAVETASCRNVGRAGSLGVTYKGVASQVRVVEIASCRNVRIRLCTIDPYGPPFSRVQGSDTGIDLKGSLDVTYKGVASQVRAVETVSCRNVGIFKGDAPIPKWLSQGAKNLIRRILDPNPQTRITMAEIKEDEWFKQDYTPAIPDEEEDLESDDASSDDEVLTVHDAPIDTERDSESPSLINNAFQLIGMSSCLDLSGFFENEDASERKIRFTSNLSPKELLERIENLAVQMGFQVQKKTGKLKVLLEHKGQKTQANLSIVAEVFEISTSLYVVELQKSSGDSTVYRQLCNRLSDELGVQQSEELQPT
The following text describes a protein:
Function:
Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQLDTSTWFTTVLASSITLFILMQLKISFHDLHKKPSNKYLKLFKPTNPWEQKWTKIYSPLSLPQP
The following text describes a protein:
Function:
Probably participates in a plant defense mechanism. Has strong cytotoxic activity against human lymphoma U-937 GTB and human myeloma RPMI-8226/s cell lines.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
GIPCGESCVWIPCITSAIGCSCKSKVCYRN
The following text describes a protein:
Function:
This protein specifically binds sulfate and is involved in its transmembrane transport.
Subcellular Localization:
Periplasm.
Sequence:
MNKWGVGLTFLLAATSVMAKDIQLLNVSYDPTRELYEQYNKAFSAHWKQQTGDNVVIRQSHGGSGKQATSVINGIEADVVTLALAYDVDAIAERGRIDKEWIKRLPDNSAPYTSTIVFLVRKGNPKQIHDWNDLIKPGVSVITPNPKSSGGARWNYLAAWGYALHHNNNDQAKAQDFVRALYKNVEVLDSGARGSTNTFVERGIGDVLIAWENEALLAANELGKDKFEIVTPSESILAEPTVSVVDKVVEKKGTKEVAEAYLKYLYSPEGQEIAAKNYYRPRDAEVAKKYENAFPKLKLFTIDEEFGGWTKAQKEHFANGGTFDQISKR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of cd86 and MHC class II proteins, such as hla-dr alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MPLQQISVVPARESTGNGRSSVGRNKEKSKEGENDKSPGCSASQSNNISKARSQATGTTQRRHSQSSVCPSTQDICRTSMTLHDVTEDDITHTTPVMTIMAAVREHGKKQVKRRRRRKKTSCETCMHSGYERNLKPGMEAQRFGPTDTDSSSDDQHWATARMRRSEKVKVFKKGRRREKSRQVYEGFSDTNTIEMASLPCKNSTEPNTYSQYPTSVNNSTSYRRRRKELKCNAPAETKHIANRKPKRKENCCKDSVKCQCFCREGNIIKKNIREEGAGADVQAPVITVPLARAPSPVNSNDVSEDLDVCRICHCEGDEENPLITPCLCTGTLRFVHQTCLHQWIKSSDTRCCELCKYDFVMETKLKPLRKWEKLQMTKSERSKIICSVTFHIIALTCVMWSLYVLIDRTAEEIKQGSENGVLEWPFWTKLVVVAIGFTGGLIFMYVQCKVYIQLWRRLKAYNRVIFVQNCPNTSKKLEEKDSTSNQNTNLKESVAVPVLQTSAIMQSCSTAVASGSMAV
The following text describes a protein:
Function:
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Has no activity towards mRNA molecules longer than 25 nucleotides. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCS1 to m7GMP. Inhibits mRNA translation. Binds to the m7GpppG cap analog.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly nuclear.
Sequence:
MEESSAAKIQLLKEFKFEKILKDDTKSKIITLYGKIRNEVALLLLEKTAFDLNTIKLDQLATFLQDTKLVENNDVFHWFLSTNFQDCSTLPSVKSTLIWPASETHVRKYSSQKKRMVCETPEMYLKVTKPFIETQRGPQIQWVENILTHKAEAERIVVEDPDPLNGFIVIPDLKWDRQTMSALNLMAIVHATDIASIRDLKYKHIPLLENIRNKVLTEVPKQFSVDKNQLKMFVHYLPSYYHLHVHILHVDHETGDGSAVGRAILLDDVIDRLRNSPDGLENVNITFNIGEQHFLFQPLTNMNA
The following text describes a protein:
Function:
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Sequence:
MQKTDNLRIKAIHPLMLPALLIEELPITAAVASTVNLARLAARDIIHGQDDRLLVVLGPCSIHDVKAALEYANRLKRCIDRHAKELCIIMRVYFEKPRTTVGWKGLINDPQLDGSFHINQGLRVARRLLLDINEIGVPTGSEFLDTIIPQYISDLTSWSAIGARTTESQTHRELASGLSMPIGFKNGTTGNVQIAIDAVLAARQAHHFLGVSKQGIAAIIITKGNPDGHVILRGSSQSTNYDPKSIEEAILKLKANHLPPSVMVDCSHGNSRKNHKNQMRVVDALYDQITQGSSYLLGAMIESNLVEGKQTLESGKALTYGQSITDACISWEDTELALEKLAQAVIIRRQHSEERKHHGE
The following text describes a protein:
Function:
RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).
Sequence:
MAKVREVYQSFTDSTTKTLIQDEAYRNIRPIMEKHKLANPYAQTVEAANDLEGFGIATNPYSIELHTHAAAKTIENKLLEVLGSILPQEPVTFMFLKPRKLNYMRRNPRIKDIFHNVAIEPRDVARYPKETIIDKLTEITTETAYISDTLHFLDPSYIVETFQNCPKLQTLYATLVLPVEAAFKMESTHPNIYSLKYFGDGFQYIPGNHGGGAYHHEFAHLQWLKVGKIKWRDPKDSFLGHLNYTTEQVEMHTVTVQLQESFAANHLYCIRRGDLLTPEVRTFGQPDRYVIPPQIFLPKVHNCKKPILKKTMMQLFLYVRTVKVAKNCDIFAKVRQLIKSSDLDKYSAVELVYLVSYMEFLADLQATTCFSDTLSGGLLTKTLAPVRAWIQEKKMQLFGLEDYAKLVKAVDFHPVDFSFKVETWDFRFHPLQAWKAFRPREVSDVEEMESLFSDGDLLDCFTRMPAYAVNAEEDLATIRKTPEMDVGQEVKEPAGDRNQYSNPAETFLNKLHRKHSREVKHQAVKKAKRLAEIQESMRAEGEAEPNETSGGMGAIPSNAELPGTSDARQELTLPTTKPVPARWEDASFTDSSVEEEQVRLLGEEAVKTATQQVIEGLPWKHWIPQLNAVGFKALLIQRDRSGTMIMPITEMVSGLEKEDFPEGTPKELARELLVMNRSPATIPLDLLRARDYGSDVKNKRIGAITKTQATSWGEYLTGKIESLTERKVATCVIHGAGGSGKSHAIQKALREIGKGSDITVVLPTNELRLDWSKKVPNTEPYMFKTYEKALIGGTGSIVIFDDYSKLPPGYIEALVCFYSKIKLIILTGDSRQSVYHETAEDASIRHLGPATEYFSKYCRYYLNATHRNKKDLANMLGVYSERTGVTEISMSAEFLEGIPTLVPSDEKRKLYMGTGRNDTFTYAGCQGLTKPKVQIVLDHNTQVCSANVMYTALSRATDRIHFVNTSANSSAFWEKLDSTPYLKTFLSVVREQALREYEPAEAEPIQEPEPQTHMCVENEESVLEEYKEELLEKFDREIHSESHGHSNCVQTEDTTIQLFSHQQAKDETLLWATIDARLKTSNQEANFREFLSKKDIGDVLFLNYQKAMGLPKERIPFSQEVWEACAHEVQSKYLSKSKCNLINGTVRQSPDFDENKIMVFLKSQWVTKVEKLGLPKIKPGQTIAAFYQQTVMLFGTMARYMRWFRQAFQPKEVFINCETTPEDMSVWALNNWNFSRPSLANDYTAFDQSQDGAMLQFEVLKAKHHCIPEEIIQAYIDIKTNAQIFLGTLSIMRLTGEGPTFDANTECNIAYTHTKFDIPAGTAQVYAGDDSALDCVPEVKHSFHRLEDKLLLKSKPVITQQKKGSWPEFCGWLITPKGVMKDPIKLHVSLKLAEAKGELKKCQDSYEIDLSYAYDHKDSLHDLFDEKQCQAHTLTCRTLIKSGRGTVSLPRLRNFL
The following text describes a protein:
Function:
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
Sequence:
MAPLKFCANVSWIFTEVPDLSRRIQAAAAAGFQAVEAAWILDSNLQELQRVKESAGVELVLLNTPPGDLKAGDLGLGAVPGREAEFRRGLDQTVDFAKALNCKRIHLMAGRIPAGSSRASAAREMEAVFIQNLRYAADVLQKEEMTGLIEPINTRITDPTYFLDSPHQAAEILEKVGRPNIKLQMVSHVQVAQVPGRNEPDSPGELNFKYLFNTLENLDYQGYVGCEYKPLGSTEGGLGWIKEYWALGSESGGSSLKL
The following text describes a protein:
Function:
Confers resistance to heavy metal ions (e.g. cadmium (CdCl(2)) and copper (CuCl(2))) by chelating them at the plasma membrane of root cells, thus stopping their entry and reducing their accumulation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Secreted, cell wall.
Sequence:
MYNAPPPQDMSYYDHCQRRHEEKGCLYACIFTALCCFCCYETCECCLDCLCCCCN
The following text describes a protein:
Function:
May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV
The following text describes a protein:
Function:
In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development. Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
Subcellular Localization:
Secreted.
Sequence:
MCPWKVGQVAVLLLLAVTVGNAQELDRTLILSNERSSIERTYELTKYLDHQLKEIRDTYLSYLGPPFSDPGFSPPRPNSSSLSVPSAATRVDLWRGLENGARLAQNQHAYSILLCAVRELARSTLCPYLQSSLLHFCSGLSGLLGSISGLMNALGYTNLPSSAGYATPAQGYAPAMSSQFQGVSENSPAPLRSYVPRNQGAKTVSGVREGTTRADLKRDREKERAERGRRGRRKEGESWVAKEEGEKEEGMERWGKRRRLLSMDEEKTIKLNNMNYTSLKFGDGYRKQPLLFSTPSLHPRRSVRSIPSSHSGLSPLSLLYQYGGPVSEVHTLLAAPVLSSHPTANDFSRKVEGFWVLRELQSWLWRSAKDFTRLKKRLRV
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
Sequence:
MQTNLSATTGNVWIDCEDHENINENTDNVSIETADLLMNALSNLTFDDEGFATETSDAQLQVEDSILGLLREHSCNPNPVLLRSKHIDYIQHAFAGLKCGWVSLDASKPWLIMWMMHTLDLLGTEIPLTIKIRAVSSLAACQHPDGGYGGGPGQIPHLATTYAAVNALAIIGTEDAFQSINRWKLYNFLEQMKQENGSYRMHNGGEIDVRGTYCAVNTAKLLHILTDKLMDRASEFIVQCQSYEGGMGAVPGIEAHGGYSYCAVAAMEIMGKMNMLDMDALTQWVCSRQMALEGGFSGRANKLVDGCYSLWQGGIVSLIEMHLKRKTGQQVNLLNRDALERYIVVCCQGGRGGLRDKPRKPVDYYHTCYCLSGLSVAQHIYTEHNGQVTAVPRSPIFGSSTNLVNPTHPAYNICINRAKNIIDYFSKIDMTESRS
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.
Subcellular Localization:
Cytoplasm.
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA.
Sequence:
MNTSEQDRWSRVKGRLRSSVGEDIYTSWFARMDLEDVQDESVRLSVPTRFLKSWIQAHYAERVLSCWQAEMPEVHRIDLTVRSAVRPVAPPKEAPAPVETRRAPAPELRSTATAPVSANHDALGGSPLDPRLTFASFVIGRSNTLAHAAARQVAEGRRGDPVMFNPLYIHAGVGLGKTHLLQAVTWAGNSGNERKVLYLTAEKFMYGFVAALKTQTALAFKEALRGIDVLVIDDLQFLQGKSTQAEFCHTLNALIDAGRQVVIAADRPPSDLESLDDRVRSRLAGGLVVEMGSLGEELRHGILKSRVAAARAHHATFDVPEEVLHYLARTITHNGRDLEGAINRLLAHSKLNNQPVTLEMAEREVRDLVRPQEPKRIKIEDIQRVVARQYNVSRSDLLSSRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEALVSKDTALSEEVESLKRQLQE
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSGRGGGRGGRGGGRFGGRGGAPMGPVARDEDGTILATAPAGPPPLFPETELPEHPEITAKDKMLLLRRFELSHRSKFSPYFLELPKSQKDTGALDEAFDPYKAPEAAAAGAAAAAAGGAAAANGAGPSGGAAGAGAGAVAAATAPSGIVGSKRSRPPLSSVMTLIPDYFPEDLYTSKDMRASRLQTLKGQDAYFRAQARGGDDATSLKRLEQLAKMEGAREGEEGGGAGGRKGPGGEGGDEEEGAEEEQLHDTDEEEDMEDDDYYQGEHFDDDEGYGDAFDEGGDEGPVY
The following text describes a protein:
Function:
Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
Has several major domains; the N-terminal cytoplasmic domain is followed by 2 transmembrane helices that anchor the protein in the membrane; the periplasmic domain between the helices interacts with MrzA. The cytoplasmic C-terminal domain has a HAMP domain joined by a flexible linker to a histidine kinase domain. The HAMP domain by itself is intrinsically disordered. The cytoplasmic dimerization domain (CDD) forms an osmosensitive core and includes the autophosphorylated histidine residue.
Sequence:
MRRMRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYTNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNSVLGEVIAAESGYEREINTALQAGSIQVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTESHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVPVARVQGTTKEA
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPMSRYEIRNEYSLADPDLYRTADKDDPEALLEGVAMAGLVGVLRQLGDLAEFAADVFHNLHEEVMATAARGHGLMMRVEQLETEVPSIERAYLSQTDHSSFFYQADAGVDWHPSLHIDQNLVTQGDLPRFIMDSYEECRAPPRLFLLDKFDVAGAGACLKRYTDPSFFKVETSGMTRSDIQREKKIRKGKVFTKKGPRWRNGENPEVLSTSHTKLHQLFMEEHVENGVSNPSRRVKLKRRLNGFPFDSASGKTYMEKFLSTPTPDREVLHEVTVHSSALMLATYEHNESGLEVRPVSPDGENMGSKRSPPSSPDREEIVLNPSMYNPSGVPTDDKICEVHNSYPSIATDHISSSLDEASGEKVIAVDTESNREGSLTGYQSDDIASEVDNYVDAPSTMESEMDTDSELRGKSDFTSSHKKIQPLSEASEEHLHSQSPDSQSTGGSVVSDKGSTSSRNEISSFSSDSLSSAAENSQSEKSSAKGYPSTDIPKNEVVDASSYQRTAATDHHSKSVISDDTCADRDVMTNYGLDFELVNSSLCSNESVPNSAHSGSGVVGSKDMSTRLESDEEANTLGDEEKKANLVMDPPYSSSVSDFQPQSEDDSPRSSARKHLVEERNGESLPCLSTVPDIQLHEDESDLEDHNMVENIASTSDMFSHNTDGTPGMMLSKDLIPSELDDEFPKLPENSLSVHLDIAHNENDIKSTVSEGESLTEELDNKDSNVSAESPNYFPLAHSEAGDAEDNQSSNSLDNQITSENSILLHLANSPDSQRACIGALVVDVIPEKETLLNESTEQTPNDSETIENSYTPEGLEQPTGVPLDEMDAVPICMSSTGRKLTEISWFPDLKSTSEVHAVSDESDNEEPKSSSADMVSAAPAISDSVTIDEVNVPGPNKLGEGNIDDSGLDEFENDKNSISGSHGESGLVETVDQTEAATSTFGSVFCHAIHNDPAISEISDSVPNSHLDLEVVEAATLQSSVDQSGLDRRHEFFQQNSLENHITDASSLQVNYDTEESKVEEKTGLPPTQPDQELPQSAEMSSELSSLPSVYHQQTLDHILREGDNDSASPLPLVDNQSPPSVSELHTGSPGYSVDPFDFIYPPSNPFSEANQINLSDLPPLPPLPPVQWRMTKLQHASSSTEGQIMKHKGLFPPLISPITASTNDVAYPPPTISTDSIDSSRPNESTNDVSSSPPTSSIDNVGSSPPNTSTIVDSSPPPAPMDDVGSYTPTAHTDDVCGSSAPTTSTEDVGSSPLTELVNDVSSSVEEMKHSVIQIAPETASKEEKTEASCSSVEANIIHETVELPPKIENKYQHFVVPNSTSEFPSPAEEDGVTNGSRTVKLPRPRNPLVDDVSALDKSKLRKVTERVRPQIQKVDERDSILEQIRTKSFNLKPAIASRPSTRGPNTNLRVAAILEKANAIRQAFAGSDEDDEDSWSDS
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MKPQLLLLEDVDGLGRSGDLVVAKPGYVRNYLLPKGKAVVASAGTLRLQAKLQEQRLLQAAADKEESLRLAEMLRSIVLDFQVRVDSENNMYGSVTVNDMISAAEQQGVVLTRKNFPRSHSGIKNLGRHVVGLKLKEGVTADLHLEVRADHEIIEQKELQSAEEQEG
The following text describes a protein:
Function:
Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Sequence:
MSQHHKIQLSIVKKPYDRPIHFKVDGKRFDQERTVKFNVNAKYIVNITVTPPLIIEQLTMMGAKLEVDEMKRTDEEVAVFRAEMVTSGLTKDIKGSRQKFPIQIQFKNTGEMLTNFQCKFYGEHETQHTCWGNPLNHIEYDVHLSEGRFIIEAEHFR
The following text describes a protein:
Function:
Baseplate protein that may be part of the wedges of the baseplate.
Subcellular Localization:
Virion. Note=Part of the baseplate.
Sequence:
MPIIDLNQLPAPDVVEELDFESILAERKATLISLYPEDQQEAVARTLTLESEPLVKLLEENAYRELIWRQRVNEAARAVMLACAAGNDLDVIGANYNTTRLTITPADDSTIPPTPAVMESDTDYRLRIQQAFEGLSVAGSVGAYQYHGRSADGRVADISVTSPSPACVTISVLSRENNGVASEDLLAVVRNALNGEDVRPVADRVTVQSAAIVEYQINATLYLYPGPESEPIRAAAVKKLEAYITAQHRLGRDIRLSAIYAALHVEGVQRVELAAPLADIVLNSTQASFCTEYRVVTGGSDE