lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA (By similarity).
Sequence:
MAVLNQLPVLGMIKEFRRSWRALCSSERTTLCGPDSMLLALQLSMAENNKQHRGEFTVCLSDVLLTWKYFLHEKLNLPIENMKVVEHYEDIKKTYDDFLKNSNTLDLIDVYKKCSSLTSNYENNMISPIQLRDFLSGTEYAVSDEANPHMPESPVKCSQNDEQVRVLVKKIFFSYLSLLVNSKNDLALASILNIPDRGLGREAFTNLKHAAREKQLSMFLMATSFIRTLELGGKGYAPSPSDPLWAHVKGLSEFINFIDKLDEILGKIPNPSLAGSRILSAIKMQLIKGHSSGEPFYKAVEEVVQDLNLRIKNIINSQEGVAVSANNISPVPPKSFAINHDTAYCGRDAVKILLVLLDEDAASAPTRNKAELLYNDESTVPHSGPSVLTLFRSPTQEKNTSVKPLRERIHKSLQTEKNKMWQTLIRSQFACTYKDDCIMSKNKWHVNSSSKPLSALHLEDDVSEGAQSSVGKARIEASSENAHVGRWKGDKLPRKSTQRQISKGKQLDLDSENLHCDRGNELYQHKNIKIPKVPSGSHSKAGGKLAQGTKGNRCPARGKLIPGQTKLTQFFML
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAEMLMLSSSDSIELNKFENKIRESRSFNWVLVRDTLRFLRKSKARKSNLVSKYGLKLVNEYISKLDAQESYDIIEQVLVSLLECGDDENANKLFNILKSKFGRESVRVQRLQAMIHESNFQLKDALDIYNSILEKYPADQMSYKRQVSIFKCQGNLTKAIQVLNTYLQIFMCDIEAWLELSSLHITFLSYSTALICLEEVILNAPINYIFYIKYAETLYSLGGIDNYNMAIQYYTHSLELNSPTEIDVLGHPPTYLPAIYGIIMSIFSLSDENVQIKESQLKLMEWAQNHLILITNKYSPDKLTFVKHFIDSTDIFNKE
The following text describes a protein:
Function:
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
Subcellular Localization:
Cytoplasm.
Sequence:
MMNQDIEKVLISEEQIQEKVRELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYLEMDFMAVSSYGHSTVSTAEVKILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKAKSVKIVTFLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDYKEQYRNLPYVGVLKPSVYSN
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MSVLQVLHYPDERLRKIAAPVKEVNGEIQRIVDDMFETMYAEEGIGLAATQVDVHQQIIVIDISENRDQRLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELETDGLLAICIQHEMDHLIGKLFVDYLSPLKRQRIRQKLEKMAKLNARAN
The following text describes a protein:
Function:
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
Subcellular Localization:
Nucleus.
Sequence:
MAVEARPELVGKRFLCVGGDEPPELGTIARWPWRSGVIRAVNHRDGDPVDLTVYVEFDDQEWEKREWVKVYEDFQLFLLEHQLVWAKRKEGAAGGAGAGGLLPGTKAKHIQWPALAFKPVVGKNLLSSVTAVEFLLDRKLDFLSEHSACQPYQDEVDSQNPLFRDNPQLHEEVKSWLKDQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFSRNMVVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRSSQNSNTAHMAGGRPCGTTGNSQQSHYTRAQANSPRPVMTSSGPNPKSSPQQQSQSQQVQLALNPLHHSPGGSGREQREPRASRSSRRKGSDSSVPEEDKEAAGRESKAKVKQTMNKRRKGEEDEKKAGLKRLKTEVTSDLSDCSDSENLHNKRTTDSSCCSSSSSSLSSSSYSSSSSSEVNSENELKMRSSDEVQSTISQVEEEEEKPGMKGPKMNDSSSLVGHLSPWADMEAAEKLKKSVLKESVKMMTKEEEELVAVTQITQSPLQPSQLMVDMSQGGPLESIKNAVKAPGAAVIDITDDAQATVHRESSEAVSALLASQKAESTALSPYLPLNPSPVSSPPVPPASSPSEGCRRTDVESHAKQHGFMGGGVPSAKSNKIEFGSSEVIRSVSSMSDSLPLTEKSVPPHPQQQHEQRQYTSTPPSTAPPFSNEAKKLPPHKTNTSAPTDFVRSKTSPGPNPSSSHFESLKQKSPSTPQNQHHPDLADLKVKPSPGPLDVSKPRPNTSPDISKHKITRYSEASPPPARLPTKEEPAEPQRSGFKPVAMRSEAGATGSSTKSPLIIDKNETFTVYRDPALVQSDAESSSNHVAAYLHPHLHPLHPSSPHSPCLTPASHTHATSHLLAPPHSSALPHPHLLASGMLPAMPPPATSLLGSHARLESPGSLGHLALAHPAATHQQQFLQGHGRTPGLSLYPILWQYPNGTPASYPPGLNLPPTPKWVHSETPVSSDSPLRRNTTSPWLHQAASDSLGLLNHLPVRPASADAHRPPGKMPAHSNPSMTKASLSVQKETLAQLKQDQVDRSRTPAGKDVLHHRLYLDPHSTSRLGNPQEAGQGADRAVKYKEENRQILKESIEVAPFTSKIQRSMDPVMDRERTRDPAFPVPVRALTSQSPKASLTHPNIIHQEKSNYFTTLSNSVVNEPPRLYPSKEMAPYYEKVSAGIVTSVGAVVPSQGLQSLGNYSSKASLSKPPPLIKHQPEGGEGLAGKITEQLSQQVTLVQQQHHASVDRMERCSPAISSSSNHHHHQQQQHHQLRTMPSLYRAPVFHPPTQQALDCKEAVEREKEWERERAGFGGRLSPPTLTPIQPVSLALAGTKTLVEQQKPPTLLPELRDIKSHRVGAAVTSVAPATSVDVTADGWRGRTVTQGREAVFSRERDASRGKPPAAVASVIVGPTSAKYDSLVGANRSGAIIHKEPPSGRFYPSKLEGESARFGESPREPGARRVIQSNVDDRCQSSFVHGPLSSSSPLNRSAVLVSSAVDLQNKTLKSAFSSRDEVPHLKAGVGGWPLGQSSADKEGENHVAFDSHAGFSGLSLPQTNSTVASLPSQSPASPSYSVSGSSQPYSSSFIHLKKHKAALAAAQSRTSLPIAPPSVTTGSPTLSESSDKTPNHTSTPPPSCSQASSSSESSSSGSAAGRSTPGKSSPVPNGQTMAAAGCGQPINYHKLKKAWLTRHSEEDKNTTATTSSTTTKAEKLLTTTTSSCSATAMSDMIRPCTVNLSASTSSEVDMSKEGGSRLERERQAEEKSGGEDRKSRRGHKRSYDSGSETAGDDSDGSDSKMEGRAKRQPKPTYKKKQNDMARRRGDADKDDDDGKPNGIFRSAREKTKLKLASSNGIPRSVLKDWRKVKKLKQTGESFLQDDSCSEIGPNLQKCRECRVVRSKKGEEPTHSPVFCRFYYFRRLSFSKNGVIRMDGFSAPDQFDDEALALWVPSAMEDAHLDKTTAKYILGFIGDKFCQMVVTENTAASWVKKDAKMAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSKDKELYVWLKCVKGQPHDHKHLMPTQIIPGTALTELVTSMHFLRDKHNIRSCCSCTSKQNALNKLPVTNGVSQVLQNVLNHSNKLALVKAEPGSLQNSEHGGIKADTNGSGGGGSSPGSDAGRGASVTPPESQSPLHFLADLAEQKSREEKKENHQSALLGKALKEDKDGDALEVLQQCKTTSLGAGGAEQGSTLRDLLTTTAGKLKLGSTDAGIAFAPVYSTASQTGKGGQAMPNILDDIIASVVENKIPASRQSITTKLSIKQDQITMGNNSCPAAAVTDDAKADRKKPTPPAAPTPEDSVSQHPGIPHSWLSNRRLLWLRDHRNQNNWKLFRECWRKGQPVLVSGIHKRLNASLWKADSFNQEFADHQGDLLNCKDQVVSNSGIKEFWDGFEDLTKRPKSKDGEPLVYRLKDWPSGEEFMALMPSRYDDLMKNLPLPEYSDPEGALNLASHLPSFFVRPDLGPRLCCAYGVAASQEQDFGTANLHLEVSDVVSVLVYVGVAKGNGVLSKTGVLKRLEEEDLDEGVRKRLKDSSETPGALWHIYLNKDVDRIQEFLHKLSKEQGSDPSQDQDPVREQAWYLSRKQRQRLLDEHGVHGWTIVQFLGDSVLVPAGAMHQIQNLHSCVQVINDFVSPEHIVKSFHLTQELRANKEEVNYEDKLQVKNILYHCVKEAVSSLKRSGSDKDADDQTS
The following text describes a protein:
Function:
A minor component of the functional amyloid in this bacterium. Probably nucleates fibril formation (Probable). Upon overexpression of the endogenous six-gene locus (fapA-fapF), cells form large clumps during liquid growth, make large amounts of biofilm and produce amyloid fibrils.
Subcellular Localization:
Fimbrium. Secreted. Note=Part of an extracellular amyloid fibril.
Sequence:
MKRLSALLLAFACIASLQADPLASRNRASIDDSGTYRGNFALNQAAGDAQQQSNVRVVAVGSAALVGSDQRQHLQLDASQPIAASASISGAALRGSGILGVNQGAGLGNQQINAFRLSLSNGPESLDDSVLAQSVALTKVSGSATPVPGGRSVSTDDRAFAGSSGVVQVNQSAGVGNQSMNTLSVRVME
The following text describes a protein:
Function:
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MNLKDITDPSDFKTTKLPALAELDILKRCYICKDLLNAPVRTQCDHTYCSQCIREFLLRDNRCPLCKTEVFESGLKRDPLLEEIVISYASLRPHLLRLLEIEKVESKQEVDREKSANESASNGNRNVNNDVDETVRVKDQSNADELGEEKGQAQHGEQVNEQTTEVISLLSDDEENGSDSLVKCPICFERMELDVLQGKHIDDCLSGKSTKRTPTDILSPKAKRPKQITSFFKPTIDTKTPSPPTSKASTTPTATPTTTLLKANVSSPSPVAQSTVHKGKPLPKLDFSSLSTQKIKAKLSDLKLPTTGSRNEMEARYLHYYVIYNANLDSNHPVKESILRQQLKQWEMVQHQPSFGDAEWKGAETGNWKELIARARSN
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. TUB4 is an important spindle pole body component that organizes both cytoplasmic and nuclear microtubule arrays.
Miscellaneous:
MISCELLANEOUS: Present with 7200 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MGGEIITLQAGQCGNHVGKFLWSQLAKEHAIGTDGLSQLPDSSTERDDDTKPFFRENSRNKFTPRAIMMDSEPSVIADVENTFRGFFDPRNTWVASDGASAGNSWANGYDIGTRNQDDILNKIDKEIDSTDNFEGFQLLHSVAGGTGSGLGSNLLEALCDRYPKKILTTYSVFPARSSEVVVQSYNTILALRRLIEDSDATVVFDNASLLNISGKVFRNPNIDLQHTNQLISTIISSVTNSIRFPSYMYSSMSSIYSTLIPSPELHFLSPSFTPFTSDYIHDDIAHKGHSSYDVMLDLLDPSNSLVSTAMNNPTYFNVYNTIIGNVEPRQISRAMTKLQQRIKFPSWSSSAMHVNIGRRSPYLPLQPNENEVSGMMLSNMSTVVNVFENACNTFDKVFAKGAFLNNYNVGDLFQSMQNVQDEFAESREVVQSLMEDYVAAEQDSYLDDVLVDDENMVGELEEDLDADGDHKLV
The following text describes a protein:
Function:
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=A constitutive cytoplasmic pool is present that localizes to intracellular microvesicles termed chitosomes. Chitosomes constitute a separate secretory route distinct from the typical secretory pathway and serve as a vehicle for delivering the enzyme to the sites on the cell surface where polysaccharide sythesis takes place (By similarity). Localizes to septa of yeast-like cells and to the basal septum separating the living tip cell from the vacuolated part in hyphae. Also localizes to the growing bud tip in yeast-like cells and in a tip-ward gradient at the hyphal apex.
Sequence:
MNPFESLPDAARPAQGTRPNRSDGPPPLPPLTIPGSTGRPQNPIFSPPPNLHHILPPGYLPQQQQQQQQQQQQQQQRSQQPFFSPPPPDAMSPPLGSHQAYLNSTSSQPTQRLPGISFQEPQRMPVQRSGPSRDSVKSYGDDKRSINDPNSSSTALTQVNSLDPESGFSAHNDTFRRKKSLVRPDRERMDPSHRQWYYRNHAAHMDVMAASGGRVGYMPSTTGHLPQHGAAPHGSGMAGIVGPGGGLSGLGVTGPTNVPPGGLGRAPPLRRGKSLLGRDEDQVETGINVLKRGVSLRRKQSKSGNKPSKEVPRDLGESKTSRIAPGPVGGWMIYCYILTICCPGPFLRIFGIRTPEQQRAWREKMGLIGIITLIMAAVGFLTFGFTQTVCGQQPDRYTLGTIDVGSMTFNGYDYSFDGFIHPQVGPFGADTIYNRTNPIYSEPWSSGGQDGSLLFQKIGAACTGIISNRAGGAQPERYFDCTLVRQDGKGGYANSTMPMCHTGSIVDQFNDGAQPRNSVLKKRGQVSLQWNNVTDPARNLAVYRGSVLDLNRLNNLTTGLSYPELYDTLKRRNDSWAGRDVTSAVMRQRLEREFQCLEQITRVGFIDSETIGCVASKVELYLSLVFIIGVVAIKFFMAVMFGWFISWRLGNYANETYEQRMKRAAEIEQWSDDIYRPAPAGYRPNARKHKSFLPAKSRFSVADPLSLKSGSRAPMPLSEKRMTRASRLGVASPLGGSPPGSPSVAGGRSSASLAPAHSRRSSFSGSPAEGAMGVCPFPLHNTIPQPGPDYRPFGFQLAHSICLVTAYSESFEGLRTTLDSLATTDYPNSHKLLLVIADGIVKGAGSDISTPDICLSMMKDLVIPAEEVEGNSYVAIADGYKRHNMCKIYAGFYDYDDETVERSKQQRVPMILVAKCGTPLEADSAKPGNRGKRDSQVLLMAFMQKVMFDERMTAFEYEFFNSIWRVTGVSPDNYEIVLCVDADTKVFPDSLSRMVACMVEDPEIMGLCGETKIANKSETWVTMIQVFEYYISHHQTKAFEACFGGVTCLPGCFSAYRIKAPKGPHGYWVPILANPDIVEHYSENVVDTLHKKNLLLLGEDRYLTTLMLKTFPKRKMMFVPQAVCKTIVPDTFRILLSQRRRWINSTVHNLFELVMVNDLCGTFCFSMRFVVFMELTGTLVLPAAIAFTLYVVVQAFLPNVPTPTIPLILLALILGLPGILIVVTSRKIAYVGWMLIYLLSLPIWNFVLPLYAYWHMDDFSWGATRVVQGENKKDNHGDADGKFDPSHIVMKRWAEFERERRWKSGTHSRDSTYDVVQRTGSPERAGSTRYSVVSSDTFHSSPFGQHDQFGRALPNAMSSSSASQFGPDVSEVSHSKSPSGARARLDAVPLLELPAPLATDAKHRSGASPTGTVVVPRPRATSPAPLPHNSGHPALGSVSAFSPTQHSAGRLPTLPGAATYEAYPHTDAADEERRPMIGSTSSSPDPEPRRYIGPDAGVRHGNVSTEQRYPTVSESAYPMQAYTAEPETDGSASPTPAQQGFNAANSNQQTRPLTRGFSLVDDGPVASAQGVRQVQRGARRSQMPNSAASPPPANRTGNLPPGAAPPSFD
The following text describes a protein:
Function:
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Has higher activity on tRNA(Asp) modified with queuosine at position 34.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPLRVLELYSGVGGMHHALRESCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLYILNILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMQFPKIESVYPQKYTMDVENKIQEKNIEPNISFDSSTQRSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDMNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQIENIYKSLTKLSQEEQITKLLMLKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILCE
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFDEGRNNSLDQVVSQDNTKDKDNHNDLLPQPSGQVSTSSPQKDNTPPSPTPSNDDPDPLELKKLSLNYDYLMYKIKDYINTLTEQTYQSILSKQYQINQEYLHDQLNLFDNYETIDEMLKTISQLEMEFLKLDQLEVFIEDFKQRLNVLEHEFDKL
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MTSYEKVRSNGAWISSRPVKILLLIFLLGPPFLLICIETIVEQRGRELTSTILDKLSFDSLSSSNKSITTSSNETITSSSTSSSNVTTKNNVSSEDDCPCYSRCEQDSLRRPSRIHSLPPALSTALAAYERMHSSCYHSRDLSKAIQAPDPNDPCRYLVFLQDGKFGLGNHILSLLSAFVYSLLTNRMLLVDTRNHIPELFCEPFRNSSWLLPPDFPYDRLLLAPMLADGLKQKFRHGSTVHLMLLSQQTPQEQLFFCPDTQTRLEKVRWIGWSSNQYYVPRFFTFPRFWRPLVSLFPDVSLTFTHLSRYLILPQNPVWEKIRRYHFAYSSLVQGKAVGVQIRRRENAEFHEPTYRRTMQCLVENGLVPSVSESGHDIPADKGQHQSRKNRTKVFVTSLQSRYYEELRNTYINKPTVDGSLVRVHTMSHDEVESQSYEQVRNALAEMWLLSLSDELVTRTRCASALHPQHQG
The following text describes a protein:
Function:
Probable oxidoreductase that may play a role as regulator of mitochondrial function.
Sequence:
MITTDVVIIGAGHNGLVCAAYLLQRGLGVTLLEKREVPGGAATTEALMPELSPQFRFNRCAIDHEFIFLGPVLQELNLAQYGLEYLFCDPSVFCPGLDGQAFMSYRSLEKTCAHIATYSPRDAEKYRQFVNYWTDLLNAVQPAFNAPPQALLDLALNYGWENLKSVLAIAGSKTKALDFIRTMIGSPEDVLNEWFDSERVKAPLARLCSEIGAPPSQKGSSSGMMMVAMRHLEGIARPKGGTGALTEALVKLVQAQGGKILTDQTVKRVLVENNQAIGVEVANGEQYRAKKGVISNIDARRLFLQLVEPGALAKVNQNLGERLERRTVNNNEAILKIDCALSGLPHFTAMAGPEDLTGTILIADSVRHVEEAHALIALGQIPDANPSLYLDIPTVLDPTMAPPGQHTLWIEFFAPYRIAGLEGTGLMGTGWTDELKEKVADRVIDKLTDYAPNLKSLIIGRRVESPAELAQRLGSYNGNVYHLDMSLDQMMFLRPLPEIANYQTPIKNLYLTGAGTHPGGSISGMPGRNCARVFLKQQRRFW
The following text describes a protein:
Function:
Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MAGQMLKRWADALVHFEYVYLNAFLRQPHTPQWIPLLVQPSQELVHKNESFNINSIFDGFLWGVPTCRRSAEKRMMRKYGSPQWHNKLILPRKDIKVCGTCGYYHEEKCLCPNCYSKVKAETTILQEQMIKELGINPVEKEVAIVYQGEKNQFNDEFFKDNKVIEVEKPRPKWFSKNLLQKSNANVIIETSTIKPHDLG
The following text describes a protein:
Function:
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSYSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFTAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYAVSITSFIPRFNFLSIDLPVVVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR
The following text describes a protein:
Function:
Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MQKFLFLLLSLILLGPLGIDLYLPTIPAIAKGLNSSESLIQSTIALFILVLGIGQLIAGPLVDKYGRKPIAIIGIVLYMLGAAMAALAVDPVMFVSSRLLQGVSVCCTAVVAFSGVRDRLSGNEAARAFGFLNGTLNIVPALAPLLGGLLAEAFGWRAPFWFLALYGLLVLVLIIMFLPETRPANTQPINGLPIKNYLRILRDSRFLVFALVNAGAMGMALTYVSLAPNVLMVDAGLSPLQFSLAFGANGFWIMAVSFFANRIIQKVGRPTCLMIGSLLMALGCFGLLFGLTQLSVDVQHHWLVYMLPVASACAGLAFMMGPATSYALEPYANEAGVASALVGFVQMAGGAALGLLAMALPIEPKLSLAIVMLAVYWRGKRAEPVNMSAASWKKYTNNGK
The following text describes a protein:
Function:
Involved in the development of the embryonic central nervous system.
Subcellular Localization:
Nucleus.
Sequence:
MSSFDVETFNGKIVYNLDGSAHIIATDNTNGGGSGSGQNCYGSTTNSLKNLSKDKGRGQEEKDIEHPSQYHREQSDNKRQEEAVDNRPGVESLGSACYKSSPKIHSFRVVSAQDANSTCQDQIRAFKIQKPILMCFICKLSFGNVKSFSLHANTEHRLNLEELDQQLLNREYSSAIIQRNMDEKPQISFLQPLANNDASADTNDTEKLQTATEGSDATLPSSPQPVFRNVSELEPENKQETEQNRLLNQDREQEPESDQHTSSSKMAAPSAYIPLSSPKVAGKLTVKFGSLNSATAKTNNLSKVSSTSSPPSTYASGEVLSPSTDNISNHKSTHCNQETEPPSSSSSEVEMKIGSMSTSPQTNDSDVPCSGFLQMQHMTTGGAYTPQVSSFHASLAALAANESNDNRVKLITEFLQQQLQQHQSSLFPSPCPDHPDLNGVDCKTCELLDIQQRSKSPSSSHHQFSQSLPQLQIQSQPQQTPHRSPCSNSVALPVSPSASSVASVGNASTATSSFTIGACSEHINGRPQGVDCARCEMLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAVTGKLLLSSSSPQVTAACPSNSGSGAGSGSSNIVGGTASLSGNATPSVTGANSSNANAGSNTNNAGTKPKPSFRCDICSYDTSVARNLRIHMTSEKHTHNMAVLQNNIKHIQAFNFLQQQQQSGTGNIASHSSGSFMPEVALADLAYNQALMIQLLHQQQQHQQSANTKLSPSSSPVSTPDQFSFSPKPIKLNHGTGAAMGIGMAMGMGMSHSNEVSCELSGDPHPLTKTDKWPMAFYSCLVCDCYSTNNLDDLNQHLLLDRSRQSSSASSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGPQNEYKMQYQQQQLAANVVQLKCNCCDFHTNSIQKLSLHTQQMRHDTMRMIFQHLLYIVQQSEMHNKSSGSAEDDPQCACPDEDQQLQLQSSKKLLLCQLCNFTAQNIHEMVQHVKGIRHLQVEQFICLQRRSENQEIPALNEVFKVTEWVMENEDVSLAPGLNLARTTTNDATTDASYAAASSAAVPAIPDVSMFSPTSPSSCATSCDKNLSQIVLPNVNNLGSGVPTTVFKCNLCEYFVQSKSEIAAHIETEHSCAESDEFITIPTNTAALQAFQTAVAAAALAAVHQRCAVINPPTQDTVDEDKDLDTNVSDGPVGIKQERLEQEVDRTTSMDVTKDLASQATDFGAPESPKVAETEVGVQCPLCLENHFREKQYLEDHLTSVHSVTRDGLSRLLLLVDQKALKKESTDIACPTDKAPYANTNALERAPTPIENTCNVSLIKSTSANPSQSVSLQGLSCQQCEASFKHEEQLLKHAQQNQHFSLQNGEYLCLAASHISRPCFMTFRTIPTMISHFQDLHMSLIISERHVYKYRCKQCSLAFKTQEKLTTHMLYHSMRDATKCSFCQRNFRSTQALQKHMEQAHAEDGTPSTRTNSPQTPMLSTEETHKHLLAESHAVEREVSGSDVSPIELETHLNKETRHLSPTPMSLDSQSHQKHLATFAALLKQQQCNSDAGGLHPEALSMSTGEMPPQLQGLQNLQHIQQHFGAVAAAAGLPINPVDMLNIMQFHHLMSLNFMNLAPPLVFGANAAGNAVSGPSALNNSITTSTATSASGLGDTHLTSGVSSIPVDSGKATAVPPQTQLNANANSQQLASNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKVTPLNDTCSVAVTGPMTSSTISLPPSGNINLSSKENATSKVLAAGKANASGPVTFSATVPVSTPLSRPESTNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQIKSEPQDDMIGATDFAYQTKQHSSFSFLKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNCQSQQQINIFETKSESGSSDVLSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEKNVAPMVTSGSVSTQFESNSSNSSSSSSSTSGGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQKQRKIYENQPNNTLFENEETKKQNINYACKKCNLVFQRYYELIRHQKNHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGSAVASHTLSTPGSAAPLPGQYTQHSFGALPSPQHLFAKSSSLTDFSPSTTPTPPQRERSNSLDQIQRPPKFDCDKCELNFNQLEKLREHQLLHLMNPGNICSDVGQNSNPEANFGPFGSILQSLQQAAAQQQQQHHQQPPTKKRKYSDCSSNADEMQSLSELEASQKKHEYLYKYFMQNETSQEVKQQFLMQQQQKKLEQGNECDFELDFLTNFYQQNELKKVSNYDFLLQYYRTHEEAKSSQQHTFSSSKKPTIEFLLQYYQLNESKKFFQLVASPQIIPDVPGYKPSLRIPKSTSDEAPYIGETSLEQATELQREKQDEQLRIDRPSEENDLSMNKNKVENINNNNINVDQSNLTETNGGVPSVETKEECTQESSLIAMDDENKYLCTRSKQKDDKEKSHYLHNLEDFLDATMIENNSQTLTFNDDEKACQKDELTQNSNAIEKRSSVSPVNVSSKQNKRLRTTILPEQLNFLYECYQSESNPSRKMLEEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRHYAHISDDNSYDGSSGKEVYSDLRSNGITVDTDLETNLQDCQLCQVTQVNIRKHAFSVEHISKMKKLLEQTTELYAQSNGSGSEDNDSDREKRFYNLSKAFLLQHVVTNATSHAIHTARQDSDVIAEGNCILNYDTNGGDSKSHVQHNLPNEVVSEDARKIAGNQELMQQLFNRNHITVIGGK
The following text describes a protein:
Function:
Plays a role in virion morphogenesis, and is ejected from the infecting particle into the bacterial cell.
Subcellular Localization:
Virion. Note=Present in the head of the virion.
Sequence:
MCFSPKIKTPKMDTNQIRAVEPAPLTQEVSSVEFGGSSDETDTEGTEVSGRKGLKVERDDSVAKSKASGNGSARMKSSIRKSAFGGKK
The following text describes a protein:
Function:
Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP).
Miscellaneous:
MISCELLANEOUS: Present with 3320 molecules/cell in log phase SD medium.
Sequence:
MSEECIENPERIKIGTDLINIRNKMNLKELIHPNEDENSTLLILNQKIDIPRPLFYKIWKLHDLKVCADGAANRLYDYLDDDETLRIKYLPNYIIGDLDSLSEKVYKYYRKNKVTIIKQTTQYSTDFTKCVNLISLHFNSPEFRSLISNKDNLQSNHGIELEKGIHTLYNTMTESLVFSKVTPISLLALGGIGGRFDQTVHSITQLYTLSENASYFKLCYMTPTDLIFLIKKNGTLIEYDPQFRNTCIGNCGLLPIGEATLVKETRGLKWDVKNWPTSVVTGRVSSSNRFVGDNCCFIDTKDDIILNVEIFVDKLIDFL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MAGRGRGGKTGTLTAEQMAMLGCTKDMPVQTAPPPTFPPVLNRPTTLETTATQNYQLLWKEDFLNRMRDSPYYMISASRDAKNLDHKDWREKAMERMKLTAQPDFNYKAMPQELNISSRKRRGADARPNLLTKKTNIEDRLKVLEQKELKSGGGEQDENKQESDSEQEEEEDPEAALDDEMDEDNDYGATYFDNGEAFNDEDDNLDDGPVY
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MEKILNVASLKNYVSSLNLPNITISKPYEVGRYSYDNHRCDYPVELSKFKKPIIDESLIKDFKGKESIPQNNDTPIMFILDTLMKNDYDVSKCSFISYRNSFRKIFESINSSKIFNSSWSIHIQRVSSTIHLGMNNTINNNNNNAEKNDALKSMYSGFAFENLSKETQYQNNFCSIVYSRLYNNNFILACEIDCYDNNNNNNNNNNNNNNNTENNQNKEKDFNIDNYIELKVTKETDQSGKYFKNKLLSYWFQSYIAGVPKVIVGFRNDSFLLKGFKAFDTNSLPRYSYPFWDKNMVLAYGNEILEFIKNNTTSGKSYRLEFDYPNLKLFESKEISLLSDDYLDYFNNKINIINNNNNNNNNNNNNNNNNNNNNNNKNFKEKRYIDIDNRDIKKNKT
The following text describes a protein:
Function:
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MDHLTTTKHTTDTEATHTQKIAGQKRDASAITTVSSQGSSASSGEGLEIRNESKREGEVKRPKLGEEQTSSNRSDNNMALIEETSMEGRQCFVTVGATAGFRPLLSEVITPEFLNCLADNHFDLLKVQCGEDFEWFDEQVKSLPSSPVTIERFAFTENMAKHYIRSRGEMSVRMPGVVVAHAGSGTILEVLRLQVPLVVVPNPTLMDNHQAELAQELESTGDAVYGRLGKLTEAIARSLELVAQGPLKLKDLPPYSPPPFPVPDSERVTLFDWMTLTCYPDELRKQQHLQDLRNVEKSFQRELEQAKVPQTETVQDRRQRDLD
The following text describes a protein:
Function:
Transducer of the DNA damage signal. Phosphorylates SML1 on serine residues. Cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.
Miscellaneous:
MISCELLANEOUS: Present with 3480 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSLSTKREHSGDVTDSSFKRQQRSNKPSSEYTCLGHLVNLIPGKEQKVEITNRNVTTIGRSRSCDVILSEPDISTFHAEFHLLQMDVDNFQRNLINVIDKSRNGTFINGNRLVKKDYILKNGDRIVFGKSCSFLFKYASSSSTDIENDDEKVSSESRSYKNDDEVFKKPQISATSSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWFNDIQQQSSVSLELQRLQITDNKIPKTYSELSCL
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MQLTEDEATEVKKWVVKKLEDISDADSDVLADYVLALIRSDAPDDEIRKASVENLEDFLREHTTRFVDELFATFGPKQQAPPAVSHTQAQPPLTHDLPQPVSLPQQAFPYNVPSGPSTDAYGAPMGGAAPAHTGPDGLNFNRKRTYHEGFQTEQEREDVPHNRTFKTPRRGRGGGRGDWMGRDGRAPQGAPGQFPPTGAGFPVMPPSFPAFDQNDPMAAMMALQSMGFPQMPGMPPMPMAAHGGAGQPQEQMMAKSSERCPFYETQGICYLGAACPYQHDTGPSAKEDEYDPKSASIMVDLQRRDGGPMRGGDRGRGRGRGGDRGGFGGRGRRSEFSAAGPSDDPSMKTIVVEQIPDEKLDEATVREFFAQYGEIVEISLQPHRKLALITYDSHAAAKRAWSSPKVIFDNRFVKVYWHKPKAERNGDQRPRGDAMDESPAFDPQEFQRQQEEAQKAYEEKMRKRKETEEAKQRLEKQREELLKKQQEEKERLLRKLGARATSNGTSPDGEARQSPADENVSEQTKQLRAQLAALEAEAKTLGIDPNASEAGATPFSYRGRGRGYTGYRGGFAPRARGYAPPFRGSFRGRGAARGRGGVLRLDNRPKRIAVSGVKLNTEKDEALRQFLIGVGEYESIESHPEQPNTVVVAFKERYQAEKFMRGPWNIPSVGEVQLSWVPNPAVSAATSAQISGPGSDTKPTSDEDTVMESTAGSSQPADQLNSRKDGSHDVDYDVAEMDDSWGVE