lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone H3 acetyltransferase that binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and catalyzes H3K18 and H3K23 acetylation. Prevents the transcriptional silencing of transgenes and of some endogenous genes. Requires the presence of IDM2 for efficient H3K18 acetylation, but not for H3K23 acetylation.
Subcellular Localization:
Nucleus. Note=Colocalizes with IDM2 within nucleoplasmic and nucleolar foci.
Domain:
The PHD finger domain specifically binds the N-terminal tail of histone H3 and this binding is inhibited by H3K4 di- or trimethylation. No effect of H3K9 methylation on the binding. The N-terminal domain (1-592) is required for interactions with IDM2.
Sequence:
MLPGAEIEMLGGDCFEGSYEDHQIFREVFFGSDPGNTTKRCLVTGAINFECDSSKNVNSSLSSNSVVTSGYACPQGFEASASRDGSDFNTKAKRVKLSGNKHLDARDEKGSALHGFPTSDIARETIPLHLVESSNKGVSTSSYLLKHSIVKGREVYLGGIVSGKCKSLNLDKCDGKEFKAIASPVSQESFATRMISVGASTPHSEKACFPLQLNNGSKVSPNELIMSKTCLKIDPKEDPRPLLYKYVCKVLTAARWKIEKRERSAGRKHVDTFYISPEGRKFREFGSAWKALGGILLADRKLMDTGTKKWTGINDFWSDLSLTLLDIEENMKNLNLANTRALWWSALEPFVVVVFISKQVGSLRKGNKVEVARNSNPDKLKKEDTICLNLISGCPESVLTVSEGSHLVHDVDANQEIHSDLEVQTKISSQKVSSRLERQSIIGKEISGTHEQEASKGIVASKLIAEDMHESVMRKNLHRRSKKISDIKPASLDQHDSLDSNSLNSFEFQDKEMGNIHLVSKGSRDERLRNEKMNNSCCNSKKGRKKARKHYTQDDDLMGSTITRNKGKFSRSSQKKKTQKPKARTKKRNNRGGCRLLPRSSSNVENHFFQGNWSILGPRTVLSWLIATKVISRDEVIQLRDPDDDTVVKTGLVTKDGVVCTCCNKTVSLSEFKNHAGFNQNCPCLNLFMGSGKPFASCQLEAWSAEYKARRNGWRLEKASDDDPNDDSCGVCGDGGELICCDNCPSTFHQACLSMQVLPEGSWYCSSCTCWICSELVSDNAERSQDFKCSQCAHKYHGTCLQGISKRRKLFPETYFCGKNCEKVYNGLSSRVGIINPNADGLSWSILKCFQEDGMVHSARRLALKAECNSKLAVALSIMEESFLSMVDPRTGIDMIPHVLYNWGSTFARLDFDGFYTVVVEKDDVMISVASIRVHGVTIAEMPLVATCSKYRRQGMCRILVAAIEEMLMSLKVEKLVVAALPSLVETWTEGFGFKPMDDEERDALKRINLMVFPGTTLLKKTLYESTKPSTMKGVCLSKERNNPSNKEADLEPGLDKAGSPMSTQVESCDQMVPAGSDDEPSPGFPVPLGADQTEPTSETENPSRDSNANDRPNKTTVVSIGEEEEEECLQKDVSKLSEEGKETTRASSSSAALEEVSGLGLGVVNNVSDEMLLCVDEQLDSDSSQDSE
The following text describes a protein:
Function:
Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAWPPLYWLCMLGTLVGLLATPAPNNCPDRHYWIGAGLCCQMCGPGTFLVKHCDQDRAAAQCDPCIPGTSFSPDYHTRPHCESCRHCNSEKPSWPPQRQLPDSTVYSRLPSQRPLCSSDCIRIFVTFSSMLLVFVLGGILFFHQRRNHGPNEDSQAVPEELCPYSCPREEEGSVIPIQEDYRKPEPASYP
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNTGGNNSLPPQTRGEVLFRDQQFFQKQIDSKIMQLLENYHNIIKISKVNDPLKNASEIYEMETRTSNMLNAGEGLLKIIEELKQNLILNDFSTMAEEVRIQNLVFHKENERTNKSIKLISEELSRSLKELEDEYYNSSYKLPPPSSSK
The following text describes a protein:
Function:
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose.
Sequence:
MFNLCYKGQKLQRIVQSKRMEEPYFTFGIIADIQYADKDNRLNYLKTSMRYYRNSLTQLKVAIKEWATESIKPKFILQLGDIIDGVNTKDNSSTIALERVLEEMDKLPIQFHHVWGNHEFYNFSREYLNGSKLNSRARENRIDQQVGTSESGETNDESFYAYHFSPFPKFRFLLIDGYDLSPIGREKTSLKYDISFNLLKEKNPNEDLNSPTGLEEEQFVLFNGGISPSQLDWIQSILTSSDKKEEKVFVVSHLPVHPDAADTMCLIWNYPEVLSMLQSHPCVVGYLAGHNHEGRYCMDPSGIHHMTFSGVIETPPESQAFGTMYVYEDKMVLKGRGLVEDRTLHYRDPKNMQVGH
The following text describes a protein:
Function:
Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.
Subcellular Localization:
Nucleus. Note=Associates to transcriptionally active chromatin.
Sequence:
MAQQQQQQMQQQQQHHTSSINNNNSSSIVLLQQQQPQQQQQQLDQLQQYNNNLYSQNYNMEEYERRKRREREKIERQQGIQIDDRETSLFGEPRRLTEGDAEITAALGEFFEAREYINNQTVGISRSAPGAGNPRLQPNLAPQAKSLGHSPSSASSAAGPTAASATTSLPGQQQHYQQQQRPPTYVKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRTSSSNSNSSSVTNNASSGGVPASTPLGPPLSTQMPNGREKSFLGPPAPALHNGTGGRFVPPAASKRPGVGQQPPPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTRENYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPITSPIAPLVTTPPQASQMPLGGATSGTILAGEALAPLHQLPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLENDLELSESEDEQRKKEGRSGGNSSNSSESDSSESGSESSSKNDLQHHPNHQQHHHQLQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVNSNAVVGTGSGSGGTLSSGGSSSNKTPSPTESNKWNLSRFFHKPANQTNSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGETLQLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQRQKKPRKKKAITSAPILDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKINTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERDREREQPPGRRRKRSSSSSSSPYKEKKRKKEKADQLQMGKELLPVPVLLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPNGSPTKKLLAMSPLPPPPTVTVAPATCNEAVQTTPPSATATSAIAPPVPATRLIYRSYFDRDVEHPSDDPRKNNQFLQEAINRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSEQATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFRVGRGDIANGNTPSSISPSNSVGSQGSGSNTPPGRIVPPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSHPTHQSQ
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAVFEADAPVTSVKLEGLAALKIIKHCQESLPTMVTGSLLGLMIEDGVLEITHAFPFPEPLDDKGDIVKTAEEAANADDEAAALDGHEFQLEMMKMLREVNVDNNCVGWYQSMYLGSYSTSSLLENQLSYQTDLSPNAVVILYDPMQTAHGNLVLKCYRLTEEAVQLKQSGKNNYINPRKIFEEVPVTLSNPGLVRSLLRDVGDGLHGSYDAEGTGADTTFDRLDLSTNPYLEKHLEFLCSWVDDLAAEQYKFQHYTRSLRSSVGDNRKGRKAKEEMAQAIEEGWTRSEAPKRMESLLMSNQIRTYCDQVEKFTGDGFGKLFLTSGLHTEEGEKKKAAA
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNISEPDSSFAFVREFILLGFSYEWKIQSLLFSLFLTIYALTITGNGAIICALWCDQRLHIPMYIFLGNFSFLEIWYVSSTVPKMLVNFLSHKKTISFVGCFLQFYFFFSLGTTECLLLAVMAFDRYLAICRPLHYPNIMNGHLCIKLVLICWVCGFLWFMIPIVLISQMPFCGPNIIDHVVCDPGPLFALACVSAPQTQLLCYSLSSIVIFGNFLFILGSYTLVLTAVLHMPSATGRQKAFSTCGSHLAVVSLFYGSLMVMYVSPGLGHSARMQKVATLFYAMVTPLFNPFIYSFRNKEIKAALRKLLGSFNIMNIEMIHRCRSVSLHKHRLLSKSNGLAIYLFTCE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MASNEAVYSDLSHSLLSMCSALLSDIEEGRQQTLFEGSSHVAQHEASQPQNRNYQTPLGGIEASHLGRDRMLVLDNTDYDEVGQESPAHDEVSHFGNLLSNEPDGIQSSCFSDTSSKPTILGHSSAPRASGVNTVSAPSCDEEKSQTDVKFLCRECGKEFNHQRFYREHCRIHTGERPLECKYCGKSFRRSNALYVHERVHTREKRYSCRICKKTFGRRDTLKTHIRTHTGETPYKCSFCDRRFNQRNGRILHEKVHKNDETFTCDECGMKFRQKFGLQNHQRASVVNRKCTECGKACPNLCTLRVHRQQVHNKKLYSCDECGTSFATERKLGKHCPCSSSNQTVFVCKRCARTFDNLQDLGSHECSKIYRNSFTCDVCEQNFSSIEDWKTHRLRHSKKKVFQCSHCDMVFKAKRNLLRHTPLHAMLCNGSLCPSNLTDGETSSTEVAEVSAALTIADLVNRNNNVHGQTELYSNNGTLTNEEQQHTSWTTSCDINISNDQSLQSSSKAPVIPLHPHPGSLSNQSPAFDLHLQNRSSAVVNTNVRENVEEKAFVCSDCGKSFGKRRSYTAHQRTHRSERPHKCEFCGMGFKQALTLTHHVRKHTGEKPFICEVCNKCFIRSDGLRNHMLIHTGSKPYKCMFCEEWFDQRSSRAVHEKAHSENGVTLCESGKDLEENCSSFTQSHLDVCLQSLDRETGEKAPTQAQIFVCLECGKVFKKRHSYTAHLRTHNPKRPHKCKFCEKSFRQSTALRHHVRKHTGEKPFACLICKKNFSRSDSLRTHMFIHTGTKPYKCKFCDTWFNQRGSRYSHETTHCSNKIPICC
The following text describes a protein:
Function:
Involved in transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSVKGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLSILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFTMLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMFLLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISSVLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFLRYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSPKATPLHSEKSIQK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLTKLGQTCAHLQNCSRVRMALTSIPYNKLHLKFAYNLYKNGFLTSLQKGSTKGPDVTPVEVTPDNIATRRLWLGMKYRENKPVLSTCRLVSKPSVRIILQVEELKKLCSGISVRLVKPLQPGELMLVRCGDDILEINEAIAKRRGGEVLCRVK
The following text describes a protein:
Function:
Binds preferentially DNA with A/T-rich content.
Sequence:
MSSHMLNGQKSSATSNSNSNSNNNNSKASSYYPPPTAKYEDIAQSSDLFWATLEAFHKSFGDKFKVPTVGGKALDLHRLFVEVTSRGGLGKVIRDRRWKEVVVVFNFPTTITSASFVLRKYYLSLLYHFEQVYYFRKEAPSSSMPDAVSGSSLDNGSASPEEGSTINQLGGQGMFHPRHFIHSSLII
The following text describes a protein:
Function:
Probable transcription factor involved in establishing and maintaining the correct radial pattern in the root apical meristem.
Subcellular Localization:
Nucleus.
Sequence:
MPPPPPPPPLTPYCRRCPPPHLPPPPPSSPNHFLLHYLHQLDHQEAAAAAMVRKRPASDMDLPPPRRHVTGDLSDVTAAAAAGVGGSGAPSSASAQLPALPTQLHQLPPAFQHHAPEVDVPAHPAPAAHAQAGGEATASTTAWVDGIIRDIIGSSGGAAVSITQLIHNVREIIHPCNPGLASLLELRLRSLLAADPAPLPPPPQPQQHALLHGAPAAAPAGLTLPPPPPLPDKRRHEHPPPCQQQQQEEPHPAPQSPKAPTAEETAAAAAAAQAAAAAAAKERKEEQRRKQRDEEGLHLLTLLLQCAEAVNADNLDDAHQTLLEIAELATPFGTSTQRVAAYFAEAMSARLVSSCLGLYAPLPPGSPAAARLHGRVAAAFQVFNGISPFVKFSHFTANQAIQEAFEREERVHIIDLDIMQGLQWPGLFHILASRPGGPPRVRLTGLGASMEALEATGKRLSDFADTLGLPFEFCAVAEKAGNVDPEKLGVTRREAVAVHWLHHSLYDVTGSDSNTLWLIQRLAPKVVTMVEQDLSHSGSFLARFVEAIHYYSALFDSLDASYGEDSPERHVVEQQLLSREIRNVLAVGGPARTGDVKFGSWREKLAQSGFRAASLAGSAAAQASLLLGMFPSDGYTLVEENGALKLGWKDLCLLTASAWRPIQVPPCR
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MRRTIVVVFFMFQCFSFNVKGFGLSYNFYEKSCPQVEDIVRNGLQPIFLTDPTSASALLRLMFHDCQVQGCDASILVDPGNGNEATEMASSKNLGIRKREIVSMVKSMVEAQCPQQVSCADILILAAREAVAVTGGPRIKVPLGRRDSSHAPSHRLPDALLPPATAGVSEMLNIFTNKGMNLEESVAVLGAHTLGITHCSNLQNRLYGRNNDELRGMEPGFAAFLRLTCQKGPLTSNLSFVLNDPTPFSFDNEYYVNAMRGRGVLKIDAEMVSNPKTAHVMKHFSMNEADFFRAFSSAFVKLSRYGVLTGKQGVIRKNCNQLS
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MGNNDDIETKRTLPQNAIAGALWTIFGKSGHLRVLTKTLEGSKTKLPAALRFDGFPPSDFDRLTEAFQTMYGITLKRHSMSSAGASWGNTDIANKHLFEPRDGEEMLSLDLGEVSQCVLPGNNRNEIEMQFLESDTVEAGTDQLVAIRFYVPPDQDADPTDKDAPTSAELLQSRITEVASVKKTSGAIIAEFDENKGTFLTPRGRYSIELYDSFLRLRGAKYDYKIKYDDISRLFLLPKQDDMHMAFVIALDKPIRQGQQRYNMLVMQCTKEQSELNINLDDATIEKEYNGEIQAHMNGSFSNLVAKTFKVITKKKVFIPGKFANANQQACVKCALRANEGHLYPLEKQFIFIHKPAVLIRFDEIESVEFQRYAGGQGSTRNFDLSVSLINTPGDNLAVKEYTFSGIDKTNYASLYSFLSQKKIRIKNIEGIGSEEPARSAPMYNEMDEGGEEMGESSEDEDYDQAKASESEESSSDEDDDDDLGSMSDDSDLAEHRKKAAKKSKDKSSKKEKPSKKSADKGSNKRKEPEKKKKQKDPNAPKRGLSAFNFFTSAKRGDIKAANPDASFAELAKLVGAEFKGLSASEKAKYEELAANDKKRYEKEMESYVPPEEDSDDESDGEKTTKKPSAKKAKKDPNAPKRPMNPYMLFANSVRAQVREENPDMSMGDVSKEIGIRYKAIDEKEKAKWQSKADAAKEVYKKEMAQYEKTKPQTEKSPSKPKTKAKDTVVKKITKPEPKSESEDSDDDAAADSSDDSGSYASESD
The following text describes a protein:
Function:
Protease that is part of the quality control system in the inner membrane of mitochondria. Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane protein.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFLNKYISNYSRTRAVSCAPVLSYKKCSYRNFNGLLQARFQSNNLSWSNRNRVVYKSFQPNPRDKRFQWIFGALIAGGGVYYFTHLEYVPISNRRRFNDVSLDFEKRMAQDAYKEVMSEYGDRMLPSYHPTTLYVSRVLKRIIAVSGMSDLKWELHVIRDPTPNAFVLPGGKVFVFEGILPMCKGEDGLAAVLAHETAHQVARHSAEKIAFTRAVSCIVFLAAASLDLSGQLSHFLLNFGLLLPFSRKMETEADYIGLMLMSQACFDPNAAKTLWERMDAAEGQMGKALAFASTHPSSKKRIRKIEEWLPEAQVKRETSDCYHETWPMLQSFKEVHW
The following text describes a protein:
Function:
Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MHPDKRGKGKGKSSSSAGEPSSSRHNGQPSSGDATPGHRGMAPGYMTVGSGSTPEAAARLVSMLDEDSGYGGSMMEGDSASSWRANIGEDRPSQPPSTILNGEASSSEHDKQRSHVLQLRYNQNKNALGRAIHGTIDTLKSFQEMNLKWPAHYPSVQVTEVQKHTQSAIGDFDPNMRSPERPRGPRRAGTTIGDDPVPGPSTEPEPEKEAPRLVTPQLAQDFSVLKLELRMGGRTQTDLVHSLEKSSIASLLDGQIQQSVRHLYALKERIEDTSSKVLVTGDLNAGKSTFCNALLRRKVLPEDQQPCTSIFCEVLDFRENGGVEEVHAIPHGSTYNRHDESTYVVFDLKDLEKIVIDNDRFSQCKIYIQDIRGVDESILNNGVVDIALIDAPGLNADSVMTTAVFARQEEIDVVVFVVSAANHFTESAKNFIFNAAREKAYIFMVVNGFDVIRDQERCQEMILKQVHGLSPATFKESSELVHFVSSNAIPMGGSGSGSSPPDDDGDDDPNDKGKGKEAEKRRDFGELETSLRRFVLEKRARSKLAPAKTYLLNVLGDMNNLATVNRDVSQSELDRVKKEIEALEPEFEESKKSRVEAGEAVERMVEDTTSDVYGYTRDTLNSCIQKVGEQDLGIEYPGLFSAYQYAEDIRDSMLHEVSETVRLCEEHARTQTVQGYNAIKNIGVLHLGNNLYADVMFRPERMFKKSVHALARQVDIDIELWDFFDVASLWERQEKVAGTSMAVTVAGMVGGRLMGGAGWLDGALGAAKIMGTNNMKRLLVPGLIAGLPKSLPHRLSAKLSQQLAAIDYTHQNALRISSEIRRALKGPANDVRIGLQRNVEKLQNKKEQTTKFKAEAEVARKYFGNLVRSSNDLRQTVHDTTALMEARRDPRSFLFFIILLLLINSPEPQQPTFNARARYEELVQREYDHLGVLNSTQYGDFDPRNEKWLNVTGLRKEDGFAWDMLEPVRQRAKAMGERVLGDNAYDGHDVPVYKNLSGYVQGEWVRSPLSQVRHPIDMGNSSMNPDSPFAQLMEYDRNLTGHAGSIRVHFTELEGMMRTDKNKTTSEISAKVVIGDDDSFGGNWWEFIAHGVHFLKSGTAVLTTTSDRYAGIFGLPHLMFDQRLFDASQSFLNRTILETIERQQNRAFPLWNPWTSSADGGNEGLFQGHHCEVVVYLQEAPVANGIDTAWLEHEMRYPTGAPMPKQLSKQMSMVAFSPDCGFVIESKGPPDFPPSEAYHLVGSKTEQFNDRARHGIIAFAMSLAFQLYFLIQQMKETATPSMRSRVSFYTIATMALGDGFTFLILVFMYLFLGTSQLALYSIAFLALFSVLTHLRFLMDIWGVQAAERERQNRQQAAAAALSTPQPPVAPTPPVAPVLNSLPLPATAPRPRPPTPIIIAPDQDDDLDEPTPTPGNNTTTTTTNPRAELGALYSRFCLLLIVLFFITIQFGTARTTYRSIYFSMLSFLYLSFWVPQIYRNTMRNCRRAFRWDYVIGTSIVRIIPVSYFYLKEDNVLFARTDSTSMAILAGWVWCQVLMLATQEILGPRWCVKNDWVPPAYDYHPILREDEEGATMPLNITTADGIDASAKAPGESKDRAKNKKVFDCSICAQDVEVPVIPAGGAEEGMGGTGMILQRRMYMVTPCRHIFHTGCLEGWMRYRLMCPNCREVLPPL
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MASHSDPPIVNANDYLLQQQLRLFWAAQLQEIIQIRDFRGHSLPISRIKKIMKSDKEVRMISAESPILLAKACELFIQELTHRSWLKAQECQRQTLKKIDLFTVLKETELFDFLVDVISMDEPEEEAPTYVPGMLGNIPNRISYYYSPMGPPAPPMAPLAPSVRPPAPSMGPPAPSMPTSPRGIMGRRAMPWVAPSMHVPPPLYPRKFGWYAAGGNPYATGGSSGQGSGDPQR
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.
Miscellaneous:
MISCELLANEOUS: Present with 3410 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Sequence:
MYLSFYITDTKNKLIFQYLLGATAPSFKHLWTRVQSTCPQLLEDSSSDDYLDHSMVGRDLEVYKYFSVINKLNYWCLASTSKSKGPLDCFTFLETIDRILLEYFDKDKLSIKKIVNNYDRISLIFNCCVEAGEPNVSDMLYVNKIKEAVPERSDLSKFISSTAHNLQQAVQLPQQRQQQLQQNQISRGSNSLIENEEIVPWRTSRASKHENNELYVDLLETFHVVFEKKKSHLRLLTGSIHGIVDVRSYLNDNPLVAVKLNTMGNDIGIPSLHDCVEINDGVFSPSNITFIPPDGKFRLLEYSVDLSSQVKQSGVRMNSIGLMSLHFQNGLGKDSDEFELSLNIENFKKVSQVDDLKIDLQFNVENADPNEIAYKIKILRNTHGRFENSIIMGQGQWIFDKSTATGTVPVLRGCIEYENTGPNFTKKVDLQTVSLEYSYIGQSASGIYVEAIDIVSGLTIGKNTKLYKGAKYKTQTGNFQVRL
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MASGTLFEDLVPDFSCPICLQWFLEPVALPCGHLYCQACIETAWGAHSSKHVCPQCREEFLEKRYTPCKLLETLIHRIRRMNPKETEEGRRSSANGRECALEQNHARLPVHEATEWCKGELGLAVSQMESNLAKLLVLKREEEEKLQNHQAVMLSLDDHISTEFRQLHHFLNVQEKVCKSRLAEEGGALLQETKERLRLLREACRSCQELLLEAQDHLELQDSSDFLTGIHSLLNRVKQQQTTPAFPVVSPTLKVLGSSKGPLQYVAWKEMKSALNIDFPLITLDPETAHPCLVLSEDCTSVRDGHVRRDIPDTPLRFNYCVAVLGCRGFCSGKHYWEVEVGNKPSWTLGLVSISINRKGKISASPSNGFWVIRFRNGVELMAKDTPPQRLCFSSFPKRVGVYLDYVGGLVSFYDAFTMGHLYSFVTPRFAGRLFPYFCPGLYNSGENASPLKICHPSLL
The following text describes a protein:
Function:
May play a role in cell differentiation in the intestinal epithelium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MESSGNRGCAGGCGAFLRSRKGLVLLGEIALCTVALLCYGASRTPGYVGLAVCELIFASIAVVLCITGLHHRVALVHWGWTDFIRCVVGCLLFLITSLIVIIGHRDGAGTAAGVFGLLAGLLLGYDAYISVPTRGGHSAAPTDPGRPLTAPQPHKETPPDPQGVMRGGKGGGFTF
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation.
Miscellaneous:
MISCELLANEOUS: Present with 520 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSSGSAGAPALSNNSTNSVAKEKSGNISGDEYLSQEEEVFDGNDIENNETKVYEESLDLDLERSNRQVWLVRLPMFLAEKWRDRNNLHGQELGKIRINKDGSKITLLLNENDNDSIPHEYDLELTKKVVENEYVFTEQNLKKYQQRKKELEADPEKQRQAYLKKQEREEELKKKQQQQKRRNNRKKFNHRVMTDRDGRDRYIPYVKTIPKKTAIVGTVCHECQVMPSMNDPNYHKIVEQRRNIVKLNNKERITTLDETVGVTMSHTGMSMRSDNSNFLKVGREKAKSNIKSIRMPKKEILDYLFKLFDEYDYWSLKGLKERTRQPEAHLKECLDKVATLVKKGPYAFKYTLRPEYKKLKEEERKATLGELADEQTGSAGDNAQGDAEADLEDEIEMEDVV
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MSRIAGTFAELKHNSRKALVTFITAGDPDLAATEALIPLLAESGADIVELGVPFSDPMADGPTIQLSSERALAAGTTLPKILDMVRRVRTRCQVPIVLMGYYNPILIHGLERFAADASAAGVDGVLLVDLPPEEAAEFKACADRHGLDVIFLLTPTSDEGRIRKVARQARGFVYYVSVTGVTGARSGVEASVSSNVAAIREAITVPVVVGFGISTPDQAAQVAASADGVVVGSAIVKLFERFTAAELGREVATFVSALREAIGN
The following text describes a protein:
Function:
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Sequence:
MEVQTECSEPPPCDPQPPGKLNKAAFKLFGKRKSGSSMPSIFSVRNKGESTGKAAGKTLELVRSKTHDGLITDTPSELDSHRKEESASSDQLHAGTPDGVSTAPLRSSITKSFSFFSLLRRSSSRAGDGTTTVGRRGRGLKGLFSSMRWRRKPQIQEDTLEVAKEVKEGDLILSSSSGSVKTEKDMTLTLEPLPQVFEESPLPGDSDKWKVASMQGIQGTNEVECGNCGPSVSQQHTVTEESPAPSPLRVQTGGLQNHKHSSSTHLSSIPTCALTPPMEHSTADPQSEQSVDRLCSMFTDVTSLKSFDSLTGCGDIIADPEEDSGNGGSATSSGTGSSSGGCMGRRLSGAGTNSERCSPAKPPLPPQVSSLASIHASCYMPAHQRPRAAPKKPQGSGVVAYMGGGEEMASPEGVDDADMQGLWHMLPQKDEDSPAPRRAEPVLHHAPARLEKRPPQVKALGLSKIPVSGSSKTGKQQPSRPSPPPVDKELQDAPPSDEGYWDSPTPGPEDEDSTFLRRDGLLRDSCSGDALYDLYDPDSPSAAGSDDDASSPTKSAGDLKMNLPSPKCSSSATSSFRSMKGSTSLPRDSKIPISVRQTPPSHSSSQGALSSNLSPTSTTPPKKTDAPPRTKIPVSKVPVRRSGGKSTSTSQSRK
The following text describes a protein:
Function:
Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I. Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry. Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation. Required for spermatogonial differentiation in both developing and adult testis.
Subcellular Localization:
Cytoplasm.
Sequence:
MNEENTDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGAVERVKKLRDYAFVHFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLLVYANKEESHSKSLGKPPTLPTRLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLG