lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta).
Subcellular Localization:
Nucleus.
Sequence:
MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDRVPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVATTDPKASKKKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKETENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQDEEDINIIDTEEDLERQLQEKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREREQLSSLQEELESLLEK
The following text describes a protein:
Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDSSSISRWFEYESGHAWCESAYKYQTLPYVAEFANTCTNLPIIVLPLVNIMLLRRYLHDVNGGLVFPQLLLTFNGLASTYYHATLNLFGQLVDELSLVWIITVFLVVYIPVMKWFPERFSKRLTVVRWVVLIVTAVVSALCFLEPNLNAIALMLFSIPAAVVIRYEGKQSGIPDIENFPSRILALWGVAFSFWFADRLLCDFWLYLGTPYLHALFHLLAGLAGYTIFIMFSMIDIESRSKTHRYTAAVRYFPDKNGSIFSFPYISLKERSQ
The following text describes a protein:
Function:
Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA.
Miscellaneous:
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKLKLIVNGCEAPDDYKLLRTTINTVASLRKTAILRFNSERLTIISTPKSSLNSSNNGTILRGDTGQLWCTIPHDVFRLYTVISARELNTITMECNCDSLLSVFKRYDRVMNQGSSSNMTIKLQSMPEWNTNNGTLSGGTAGGVDTTSKPNPICALGITFEEIVHTSGPNDAIVMNGGVDEHNGLPTTVGTGNLLASNKVIMHSFKVPVKLLFRAQDTRIQEPMINYIQLMMYKLPPISGEFGSAFHGFIRRVERYSNVNHIHLMGVKKKEHGNEGDDVELKIIVNELDWHLEICWNGPLDSVIQRQEGLTDNPSQNQHIDTDGRQEEGSLPIIEADKPMSSLYTNTRDREMEENIRYDEDLLRIEDSSIADTRGNIYTADTSGDTEFNDISVMVEKAEQESSSTHEVIIRCKDWKVCSKLYAAFEEVVLAISHDESCVFHCSLDRGSLEDSEDVEKPRERGQIIYYIARSKGL
The following text describes a protein:
Function:
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.
Sequence:
MAQSKFEYVRKFETEEKLLPNCWIVVRIDGRAFHQFSTKHNFKKPNDESALALMNKAASVVMNEFKDIVLAYGQSDEYSFVLRKDTALYNRRGPKIMTYLSSLFTSSYVYHWNQFFKETKLKYPPAFDARVVLYPSDQNLRDYLSWRQADCHINNLYNTTFWALVLKGGLTNNEAEKRLCGTLSSDKNEILFSEFNTNYNNEPEMFKKGTILIRKRIKSPKHGKARLVILPLHEDLIQDKFWEKNSEILAIKTAQLYEWPEESPLPSLVLSQLHIGEFDRDKEIVIIEETD
The following text describes a protein:
Function:
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, ZipA and FtsK, but not FtsL, FtsI and FtsN. Insertion into the membrane requires YidC and the Sec translocase.
Domain:
The C-terminal periplasmic region is necessary and sufficient for septal targeting. The transmembrane region contributes to localization to the cell division site. Three periplasmic subdomains are involved in the interactions with other cell division proteins. Localization and recruitment require two separate domains.
Sequence:
MSQAALNTRNSEEEVSSRRNNGTRLAGILFLLTVLTTVLVSGWVVLGWMEDAQRLPLSKLVLTGERHYTRNDDIRQSILALGEPGTFMTQDVNIIQTQIEQRLPWIKQVSVRKQWPDELKIHLVEYVPIARWNDQHMVDAEGNTFSVPPERTSKQVLPMLYGPEGSANEVLQGYREMGQMLAKDRFTLKEAAMTARRSWQLTLNNDIKLNLGRGDTMKRLARFVELYPVLQQQAQTDGKRISYVDLRYDSGAAVGWAPLPPEESTQQQNQAQAEQQ
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Highly sensitive to the sex pheromone of the silkworm moth, bombykol. Intriguingly, the fruit fly detectors are more sensitive than the receptors of the silkworm moth, although its ecological significance is unknown. Also responds to pyrazines.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAVSTRVATKQEVPESRRAFRNLFNCFYALGMQAPDGSRPTTSSTWQRIYACFSVVMYVWQLLLVPTFFVISYRYMGGMEITQVLTSAQVAIDAVILPAKIVALAWNLPLLRRAEHHLAALDARCREQEEFQLILDAVRFCNYLVWFYQICYAIYSSSTFVCAFLLGQPPYALYLPGLDWQRSQMQFCIQAWIEFLIMNWTCLHQASDDVYAVIYLYVVRIQVQLLARRVEKLGTDDSGQVEIYPDERRQEEHCAELQRCIVDHQTMLQLLDCISPVISRTIFVQFLITAAIMGTTMINIFIFANTNTKIASIIYLLAVTLQTAPCCYQATSLMLDNERLALAIFQCQWLGQSARFRKMLLYYLHRAQQPITLTAMKLFPINLATYFSIAKFSFSLYTLIKGMNLGERFNRTN
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MPPAITPTYSFQPMDPVPSSEAGASTSHFRAFTRTERPIETVPDSEGEEISSDDEYQDPRLRRPSPSSSQQPVEPEEFHIGDAVYLPSSYQAPLAGVLTHLWTDASEQGKIFGVCRLLHWPEWMSTMAKKRMAGITSRHEIYYTHKATSLTKRRTKTSARSGKEGDTFEAGPSLHDYSFDVDEIIAKVHIHSSHAECAKAIKESSALSAIHPNQSADQTAAPDANTNPNSNAKRRPTKPHTLYKNKSFPTHLFCERAVDPNRELFWRIDWARLIEKGKLGAGWDLHDDSSDVATSEGQGVKDLVEQVQKGSQLASAETVDSPSASRRPPRASASSAAASAIDLDSSKPNRSRATGTPSSIADLNDSAPKRRPGRPRKEDSLSAGVEARKRTYSRKKTNGFASDSDIVSDDSFQSGDEFQVEDNLLVKAMHLDTPESSDNEGSQFSAPLSDAELDDDDNDNCGKTFNLTPRKRKLPKDAPPMTPSKRRVLSTVHSMSLGLASPVKAQATPRSKARLMGLKARSLPHPTLPARPPKLSLLPSQEAQTLSAHDRAKRLLHVGATPDHLPCREDQYEEIMACVEDAVEEGIGGCVYVSGVPGTGKTATVREVIRALTARAERNEMNPFSFVEINGMKLADASQAYTLLWSAISGGQRTSPKTALGLLSSHFARVGAKMSGAAGGAGVGAGPGRAATVVLMDELDQLVTARQDVMYNMFNWPNTRGSRLVVIAVANTMDLPERTLNAKVASRLGMTRITFMPYTDRQLVEIVKSRLGICSQETDDSAVVDKASIDNGCSKVLSLDAITYVGKRVSNVSGDARRMLDVCRRSIELVELQAKVCGSLIPKPVSILDMKSVLDSMVKSGKVSHILSVSLHAKMVLLSLLSCLRRSGLAEAEFADVVAHHTAVCRMYGISSFGSTAIAHEPALTAPLATLCSLGLVVCVGQGAGTGRAAGFARLMLACQEDEVRLAFEHDPDQRLRKML
The following text describes a protein:
Function:
Tryptophan dimethylallyltransferase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde. EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline. EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine. Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A. Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus.
Sequence:
MKAANASSAEAYRVLSRAFRFDNEDQKLWWHSTAPMFAKMLETANYTTPCQYQYLITYKECVIPSLGCYPTNSAPRWLSILTRYGTPFELSLNCSNSIVRYTFEPINQHTGTDKDPFNTHAIWESLQHLLPLEKSIDLEWFRHFKHDLTLNSEESAFLAHNDRLVGGTIRTQNKLALDLKDGRFALKTYIYPALKAVVTGKTIHELVFGSVRRLAVREPRILPPLNMLEEYIRSRGSKSTASPRLVSCDLTSPAKSRIKIYLLEQMVSLEAMEDLWTLGGRRRDASTLEGLSLVRELWDLIQLSPGLKSYPAPYLPLGVIPDERLPLMANFTLHQNDPVPEPQVYFTTFGMNDMAVADALTTFFERRGWSEMARTYETTLKSYYPHADHDKLNYLHAYISFSYRDRTPYLSVYLQSFETGDWAVANLSESKVKCQDAACQPTSLPPDLSKTGVYYSGLH
The following text describes a protein:
Function:
Synthesizes sphingolipids through transfer of a phosphatidyl head group from a glycerophospholipid on to the primary hydroxyl of a ceramide in the lumen of the endoplasmic reticulum. Catalyzes the synthesis of ceramide phosphoethanolamines (CPEs) (such as N-acylsphing-4-enine 1-phosphoethanolamine) by transferring phosphoethanolamine head group, which is smaller and more hydrophilic than the phosphocholine (PC) headgroup transferred in the canonical sphingomyelin synthesis (SMS) reaction by SMS1 or SMS2, from a phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to a ceramide (such as N-acylsphing-4-enine). The larger PC prevents an efficient fit in the enzyme's catalytic pocket, leading to little or no SMS activity. In vitro, in the absence of ceramide, it has PLC activity with preference for phosphatidylinositol and phosphatidic acid, but also hydrolyzes phosphatidylethanolamine.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPARSRAGSRQRSGSLPRPSRLPLEALSSAYAPRTPDSDGAIDTGSELGPGSPAPTAEEVEEEMAGPSQLCIRRWTPRHVAVWLKEEGFFEYVDILCNKHRLDGVTLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKTHIDVLEEMGYNSDSPISPMTPFISALQSADWLCNGEPAHSCDGPIPDLSSDQYQYMNGKNKHCARRLDPEYWKTVLSCVYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKVYGSVWEKLHRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYHQSRRARIWFPMFSFFECNVNGTVPNEYCWPFSKPAIMKRLIG
The following text describes a protein:
Function:
Dephosphorylating regulator for many key proteins (By similarity). Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGQTLSEPVTEKHSVNGSNEFVLYGLSSMQGWRISMEDAHSAILSMECSAVKDPVDFFAVYDGHGGDKVAKWCGSNLPQILEKNPDFQKGDFVNALKSSFLNADKAILDDDQFHTDPSGCTATVVLRVGNKLYCANAGDSRTVLGSKGIAKPLSADHKPSNEAEKARICAAGGFVDFGRVNGNLALSRAIGDFEFKNSNLEPEKQIVTALPDVVVHEITDDDEFVVLACDGIWDCKTSQQVIEFVRRGIVAGTSLEKIAENLMDNCIASDTETTGLGCDNMTVCIVALLQENDKSAWYKKIADRVAANDGPCAPPEYAENHGPGWRSGDNNKKVIVPPNFHQVKLNGSDGYDKDANENSKEDDSTNGSLAAGFRWKEHFFPHKAEEENSSSETDIVNSNKDVADDHKEAVSAAD
The following text describes a protein:
Function:
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Sequence:
MAAPAGAGALIASPDRRRCLWSVLAAALGLLTYGVSALEVYTPKEIFVANGTQGKLTCKFKSTNTTGTLTSVSWSFQPEGTDTTVSFFHYSQGQVYAGNYPPFKDRVSWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKEILPAFPVWVVVGIVTAVVLGLTLLITMILAVIYRRRNSKRDYAGCNTSENVSPVKQVSRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDRINKSESVVYADIRKN
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Sequence:
MTKVPMTVVGAEQLRKELDMLKFERRPKITEAIASARELGDLKENAEYHAAREEQGICEARIRDIEGKLSNAQIIDVTKMVNNGRIIFGATVTILNLDTDAEVTYRIVGDDEANIKENLISVNSPIARGLVGKNEGDEVSITTPGGLTDYEIISVQYI
The following text describes a protein:
Function:
Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus envelope.
Sequence:
MDTYSVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTMRNKIQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLLVTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPHYSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVAKNILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQKNGLAPAAAIALTSICSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILNDAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQMENGLKNNPDTVDDFFRLASRYLDCCPHQLLQSSLITPIFQCALIACSLDHREANSSVMKFFINLLVWGRSNNHSRNTECRPLVVELASQHGGALVMNLIQASVFQLHSYMLVDVAEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQQQLDEFSSTVLRADTTKAISQALKTFTRLFR
The following text describes a protein:
Function:
As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
MMTIRALRSPQLALRVRVCGRCWRHDGPRHQRADPLGTDGARTEAKQEVDGAQTAARPKGFRTKAAEFFRPATNAMNEVRKYANETLTRMKRDDLEQLMFEDSRVLWKFRGPEDLDQWLVSSDKEMGGKSEAHLTLSENNTAFFHGVTNIEVPKDGATRYSGYAAMRSKQKQAAFNRRSQMDLSPFNVLNLRVRGDGRSYMITLSPEGYFSSQWNDLWCYFFFTRGGXXXXXXXIPFSKFFMTSKGRVQDAQCPVPKDRINTIGITLGDKINGPFELEIDFMGVTMDMTHKEEFAYEQYYQGPRRKRFTRKPLLSTKDW
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MYIKLNDIKRKIGGLQYSILSPQDAINLAEVKIFRDKNYDKMTGKNIEHGPLDLRMGQSLRDTQCSSCTLLNECPGHFGYIPLQLPIYHLGFFTHVVKCLKCLCYKCGQVRLTPDEINQLTQKMVHCIQTRSYNAQLKVFKKVLKKCRSNKQCPHCYCEQIGEAKKLAKGDAGKIILDTMDINALYAWNQFSNIPKQHQFLFCINPFLNDLSDLLTSIIPAPPNNIRPSKMLSNTTKADEDDLTMKLKTILYHNDLLQKQIKEGKDGMSILKTQFLTQAHYFHYFNSETPRLPQFSSKDGKVDIRGIYQRLKGKRGRLRGNLSGKRAEFTARSVISPDPNLAIDQVTIPQHIACILTVPETVTALNIKKMRDYVQNGPSIYPGAKFVKLGGVNYNLQFARRAHLAYKLKIGDVVDRHLLSEDIVIFNRQPSLHRISMMAFRARVDKWHTLRFNECVCTPFNADFDGDEMNIHLPQTYEARSEALILMDVKKNLKTIKSGESLVCLLQDFLTTAWLITNKDVFYSREQFMQFCAAFSDSNEQIDLPAPTILKPKQLWTGKQVINALLVPNRKTRLKVTHLKESWTICGWTLVMASVVFDKCELVCGNIGKKVLGASKLGLFYALIRDNSTQIAASVMQRFAKLSSRWISHYGMTIGIGDVMAPKSLIEQIHQSTEQSYLQCKHYQRSLIDADPGLTVEQTLEAKVNKTLSDVREQVGSKCQEQLKSDNKVLIMYLCGAKGSNVNVAQMIGCVGQQVISGKRVPEGFTGRTLPHFKDYILHPKAKGFVKNSFYTGMDAIEFYFHNMAGREGLTDTAVKTATTGYMQRRLVKMLEDLHIAYDLTVRSCDTKEIVQFRYGEDGLDPLAVEDANEVIKLQNLLTNSFTVLRKNQILLNKEHMLIKLDELFMIIEERHKKFLENYEATYEKEKKRVQALFKSTNQQVSEKQLQWFIRSWMERFLTMVMAPGTSVGPITSQSIGEPATQMTLKTFHSAGVAGMSITQGVPRLNEIINASKEIKTPQINVKLINRQVMDHAKQFAKSGDPQYEYAHRAVIHSAQQAQDVNIQIEQTKLMQILKKMDEIYTADNCYIELELDCHCLARLKLEFVTPKYVCALILKELKLSPDDVKYDLKIIRITVKKSSKKKQSENLLFLIKELQRKLLRLHIYGCANIKQTVIQVTDKDDKENVKGEARLFASGIGFKEILRLDNIDWKRTVSNHIMEIQSALGIEAARQSIVNEVYTTMQSHSISIDIRHILLLAELMTFKGRILGFTRQGIDQLKNSALMLASFEKTMDVFFNAAIQGKQDSMNGASQRVIIGQNVPQGTGMFDLMFPVKENTILESTINQQKFLFASK
The following text describes a protein:
Function:
Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSKAKGTGFSSIDTEDENLRERYVNQPKANASDIQDEQLDCFEQLEEKHRTKKNEEYTALKILRDVIGPLLLTITSFYLRFQHIDQNNYVVWDEAHFGKFGSYYIKHEYYHDVHPPLGKMLIALSEWMAGFDGQFDFSSNNAYPENVNFKLMRQFNATFGALCTPVAFFTAKWMGFNYFTVYLIATMVTLEHSYIVLSKFILLDSMLLFFSMTTFACMIKLYTLRKQQMTKKWSLWMLLTGLSIGCVCSVKWVGLFITVVVGLYTCIELFLLYCDKELPRIKYYKHWLIRIINLIVIPFLIYLYCFKIHFVLLYKSGTGDSTTNTLFQINLEGTQIEAGPRDVAFGSELTIRSHGLSPNLLHSHIQVYPEGSGQRQITGYGFADSNNVWKFEFSRSSGLELDQNGTLNGKIIPITDGVEVRLSHKNTGSNLHSHDVPSHVSRGNYEVSGYGSQSVGDEKDDWIVEIVKQMDSPNPVYSNENSTILHPVSTFFRLRHKVLGCYLASTGLTYPAWGFKQAEIVCKDSWSRRDKSTWWNVEDHWNHNLETAEDYVPPKSNFWTDFILTNFAMASSNNALVPDEDKYDSLSSDAWEWPTLHKGLRMCSWAGYITRYYLMGSPFNTWISTVSLIIFPFIILFILYRWRRQTLYLSDDQIWQITIQGIFPFISWMTHYLPFAMMGRVTYVHHYVPALYFAMLVFGFVLDFTLTRVHWMVKYPIYLSLFGGCIYIYNLFAPICQGMHGDKAEYLPLQWLSTWDIAP
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MEKDSSAKSLQQLMDEFILGNSSAINEIIKGIYDGHIKLSTIVELLGPYLTSVEHEKRLQGMKLLSEVLQMLSMYKMQATEVQLLVAFYSDRLQDHFSILPETLRGILALVQHQIISEEDAVTIVKGIFKEVQNQALLQADRNKVYAILAGLLDKHYEGIKIMDADFVFGYIQVMDGEKDPRNLLLALKIAKFIVQNFNIDLFLDDFFEIISCYFPIDFTPPPNLPSNENVTKEDLIIVLRESLTSTRKFAGISCAKIYTATDFQEYLQPIWTAIRQEVFLSMDDQVQELSLEALKHVVVTISSNSLQQPDQDPLNDFINMIVTETQQYLQDPELKLANPCGNVLNAVASASDRSCYSILTPIIPRLVNLYSTDKTVIFRCKVLDILIKLLNAAANCQLSEQFIAPMDWHEIVKLLQLAMDTSEEDIRLRVTASFSILIQIKDALPADEIERISNDILKRALEDPSSIVRHGSISTLATIASVLPDVIITTVIPYIRTSVTNLQLLLQCLANVKNRIENCLYLYHYLFDDILWLCVYNSLEESINSFEFKTIKIIASIGQLIYLNLDESSQKKFIDNLLELFMNGQVSVLKPMTVIDELPLKQFYPLNVASSQRQVQLIEILCKILGAIKFRDGILSPNDMITNLLDISCKSVHQPSATSAAQLLSSIINKMEEGDQLENYIKSITNTICNVLYSKNVETEMKNAVNTWIWMFAILCRYSCSLFHYSNFDIKTSFDASFQLMKALIMRSHPYSNEALIQVLKFFKLPNVGHVASAGFKIIIGDEENILCESTNAIVKFMYKNRFFMMASEKLMENYRIASKGIKHHYLTALSHLLNGVPKQMLLNHLQMLMPLLVESVSCDEESLRLSSLQTLRPLITEAPDIISNYVASMLPELLKLCNFPSSMKIRISALQSVNDLASLPIHLVVPYKSKVINELGNTVNDKKRLVFTVINPKKQQ
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Sequence:
MTLQEQKMFGLGWPEILLILGVVIIIFGPKRIPELGGALGKTLRGFKEELQTQDVDSTEVVDVELGENDPAAGKK
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAIKPITGMLRRGLVLDLSVAFGIGTTFGYAFWYGYHVPAVRKRDAFYSKLEDQRAANAAA
The following text describes a protein:
Function:
Has a broad substrate specificity hydrolyzing a variety of triglycerides and phosphatidylcholines.
Subcellular Localization:
Secreted.
Sequence:
MKETKHQHTFSIRKSAYGAASVMVASCIFVIGGGVAEANDSTTQTTTPLEVAQTSQQETHTHQTPVTSLHTATPEHVDDSKEATPLPEKAESPKTEVTVQPSSHTQEVPALHKKTQQQPAYKDKTVPESTIASKSVESNKATENEMSPVEHHASNVEKREDRLETNETTPPSVDREFSHKIINNTHVNPKTDGQTNVNVDTKTIDTVSPKDDRIDTAQPKQVDVPKENTTAQNKFTSQASDKKPTVKAAPEAVQNPENPKNKDPFVFVHGFTGFVGEVAAKGENHWGGTKANLRNHLRKAGYETYEASVSALASNHERAVELYYYLKGGRVDYGAAHSEKYGHERYGKTYEGVLKDWKPGHPVHFIGHSMGGQTIRLLEHYLRFGDKAEIAYQQQHGGIISELFKGGQDNMVTSITTIATPHNGTHASDDIGNTPTIRNILYSFAQMSSHLGTIDFGMDHWGFKRKDGESLTDYNKRIAESKIWDSEDTGLYDLTREGAEKINQKTELNPNIYYKTYTGVATHETQLGKHIADLGMEFTKILTGNYIGSVDDILWRPNDGLVSEISSQHPSDEKNISVDENSELHKGTWQVMPTMKGWDHSDFIGNDALDTKHSAIELTNFYHSISDYLMRIEKAESTKNA
The following text describes a protein:
Function:
Catalyzes the attachment of tryptophan to tRNA(Trp).
Subcellular Localization:
Cytoplasm.
Sequence:
MRVLSGIQPTGRPHWGNYFGAIRQYIDLQEDNEGFYFIADLHALTTVREPEVLRENVMNAALDLLALGLDPSKANLFVQSDIPEVTELTWLLMTGTPMGLLERCHAFKEKKAKGLTADAGLFTYPVLMAADILAYDSQIVPVGVDQVQHIEVCRDLAGSFHHAFGETFVLPKAKTLDVGAKVPGTDGQKMSKSYNNTLPLFGEVKKIRKQIMRIVTDSRPMEDPKDPTDDHLFQLYQLFAGPAEVETMAAKYRAGGFGYGEIKKAVAEVSEEYFAPARAKREELESDLDTVRDILAEGAKRAREVAASVVDRARRNCGLR
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MAAESFELIAELREFTGKSAARRMRRFEDKVPGTVYGAGKAPQSITLLQKDLLKALESESTFSSILTLKVGDKKQKVILKALQRHHTKPKIVHIDFQRIKASEKLIMNVPLHFLGEDDCPGVEAGGVVSHLQSEVEIRCLPADLPEYIEVDLSHLQLDESVHLSNLKLPAGVGLTSAVDEEHDSPIASVHMPRVSKADVEAEAAEAALAKEAATEAAEEEETEKPASEAEASGEAEQADTDKKE
The following text describes a protein:
Function:
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Subcellular Localization:
Nucleus.
Sequence:
MSRRTRGEELDELHYQDTDSDVPEQRDSKCKVKWTQEEDEQLRALVKQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESRDSKPSMYLLLELEDKDGRQSAPSSEGQGSVVTSWPPAFPALKEEESSEEEVTAAAPAQEQEPVPAEPDGVRTPEPLEDFPKREDQEGSSPETSLPYKWVVEAANLLIPAVESGLSEALDLIESDPDAWCDLSKFDLPEEPSAEGSLVGSPGQPQAWQQQPAPPRPAAAAAPSVTEYRLDGHTISDLSRSSRGELIPISPSTDVGGSGMGTPPSVLKRQRKRRVALSPVTENSASLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDEVRPEKQKRKAGMRRSPIKKVRKSLALDIVDEDVKLMMSTLPKPTSILAAGSSGLTPSGSREDSSLLNEGFLQAKPEKPAAPKPRGHFATPAPMTSAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS
The following text describes a protein:
Function:
May be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain; (Microbial infection) Required for optimal replication of E.chaffeensis.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNKCFRCQPRISLFQFSLPRCYAAVQPGCPPPQEKPVVGLPHKPDPKTVKCDYIGPPDAQSNLRPYVRHYGDEETRLARSLRLKRIEVEAWNTDFWTKHNKRFYEEKEDFIRLHKESGTSEVSADQMSHFYKAFLDKNWRIHIMYNISWYLKNFDILTLAAAVQLQRLLALAKRRS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of fructose to fructose-6-P. Also has low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine.
Sequence:
MRIGIDLGGTKTEVIALGDAGEQLYRHRLPTPRDDYRQTIETIATLVDMAEQATGQRGTVGMGIPGSISPYTGVVKNANSTWLNGQPFDKDLSARLQREVRLANDANCLAVSEAVDGAAAGAQTVFAVIIGTGCGAGVAFNGRAHIGGNGTAGEWGHNPLPWMDEDELRYREEVPCYCGKQGCIETFISGTGFAMDYRRLSGHALKGSEIIRLVEESDPVAELALRRYELRLAKSLAHVVNILDPDVIVLGGGMSNVDRLYQTVGQLIKQFVFGGECETPVRKAKHGDSSGVRGAAWLWPQE