lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (By similarity). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
Miscellaneous:
MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Postsynaptic density membrane.
Sequence:
MARQKKMGQNVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFASIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGTGGCGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
The following text describes a protein:
Function:
Microtubule-binding protein which might play a role in microtubule bundling.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associates with microtubules in interphase. Has diffuse expression throughout the cell during mitosis.
Sequence:
MEEKTQIKTFLGSKLPKYGTKSVRSTLQPMPNGTPVNLLGTSKNSNVKSYIKNNGSDCPSSHSFNWRKANKYQLCAQGVEEPNNTQNSHDKIIDPEKRVPTQGMFDKNGIKGGLKSVSLFTSKLAKPSTMFVSSTEELNQKSFSGPSNLGKFTKGTLLGRTSYSSINTPKSQLNGFYGNRSAGSMQRPRANSCATRSSSGESLAQSPDSSKSINCEKMVRSQSFSHSIQNSFLPPSSITRSHSFNRAVDLTKPYQNQQLSIRVPLRSSMLTRNSRQPEVLNGNEHLGYGFNRPYAAGGKKLALPNGPGVTSTLGYRMVHPSLLKSSRSPFSGTMTVDGNKNSPADTCVEEDATVLAKDRAANKDQELIENESYRTKNNQTMKHDAKMRYLSDDVDDISLSSLSSSDKNDLSEDFSDDFIDIEDSNRTRITPEEMSLKEEKHENGPPQDMFDSPKENEKAFSKTDEWIDISVSDRSECTKHTSGNNLVSPDTDYRAGSSFELSPSDSSDGTYMWDEEGLEPIGNVHPVGSYESSEMNSIDILNNLESCDLEDDDLMLDVDLPEDAPLENVECDNMNRFDRPDRNVRQPQEGFWKRPPQRWSGQEHYHLSHPDHYHHHGKSDLSRGSPYRESPLGHFESYGGMPFFQAQKMFVDVPENTVILDEMTLRHMVQDCTAVKTQLLKLKRLLHQHDGSGSLHDIQLSLPSSPEPEDGDKVYKNEDLLNEIKQLKDEIKKKDEKIQLLELQLATQHICHQKCKEEKCTYADKYTQTPWRRIPGGYSAPSFSPWQGSFQGIPRTVPPHRRQTSSTTAFQQPSQTHRSHPGKTNKATTYRGPQ
The following text describes a protein:
Function:
Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTNLDRPTGSSMSRAGLRFWSAALAFAVFMVDVLTPLEGAVAVLYVIAILLAARTNRRNDIIVAATGCVVLTITAYLLSHDLHEIASPALRALVSLAAIGITTLLVLQNHAATTHLAAQARLLNLSHDMIFVRDRSGVITFWNKTAEQTYGWSPDEALGQLADKLLRTSYSDRREAIEASLLDTGRWEGRVEQRTKAGAALTVDARWALQHDHLGKPVGVLETHTDVTDRVAAHSALVQSEQRYRRMFDASRIGVVEEDWSGLRTALDSLQTGGADLRDYLARNPDFVRHARRLARITDVNPALQKMAGASGSAAFIENADKLLGENDRSFLDALVAFANGEPFHEGETQLVSFDGRKVPVLFTITFPPEPDGDQNVLVFVVDITERKQAQDALLAAQAELAHAARVATLGELSASIAHEVNQPLAAIVTSGEAGLRWLRRDVPDLKEVATTIGHVVAQGRRASEIVTRIRTFLKKAAPQQDLLQIGEVIEEATALVARELAKDDVALIVEPQHGLPPVRGDRIQLQQVLVNLLINASQAMSGRPGSRVITLRAGTVDSETLAITVQDSGPGIPPDDMARLFDPFFTTKDGGMGMGLAICRTTVEAHGGRLSVVSTPGSGATFHLTLPYSQEHAPP
The following text describes a protein:
Function:
Involved in cell wall beta(1->6) glucan synthesis.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MLLLAILLSLFALIRADVNIVEPGPGDTFSGADGTVSINLKWVDNGAYPPLDKVAYYLFSLCYGPNTKIQCVYKPDTKITPDDLDKDDAGTYSYKFDIQSSVVGSGQFYVQVFAWVDGQGYTLHYTPRIELTNMGGPTTFELLTYTDTIQPVPQTSIRTGTDTNTQSFDASSVYSLPYTEQTLKTRVAPIQQQPGTKVTATTWSRRYPTSAVTFYSTFRSSLDQLSTLTPAWNYTVSSAVNYATPAAMPSDNGGWYNPIKRQSLSTRKLNVRYLSS
The following text describes a protein:
Function:
Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion.
Sequence:
MPKRGKKEEVCAAEPQEDGNEPEVKKGKKGAGKAAKEPEPVVLYEDAPDNVTSADGKKYTLKISSWNVDGIRAWIKKQGLNWVREEDPHIMCLQEIKCAEKLLPPDVKDMPEYPHKYWACPDEKEGYSGVAMLCKDKPLNVTYGIGIEEHDKEGRVITAEFDSFFVIAAYIPNSSRGLVRLDYRQRWDVDFRAYLKGLDSKKPLILCGDLNVAHQEIDLKNPKTNKKTPGFTPQERQGFGELLAEGYLDSFRELYPDKPSAYTFWTYMMNARAKNVGWRLDYFVLSKALRPALCDCKIRSKVMGSDHCPITLLMAI
The following text describes a protein:
Function:
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis.
Miscellaneous:
MISCELLANEOUS: 'Ketu' is a harbinger of misfortune in Vedic mythology.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region.
Domain:
The YTH domain mediates RNA-binding. It recognizes and binds N6-methyladenosine (m6A)-containing RNAs.
Sequence:
MSRPSSVSPRPPAPSGGGTGGGGGGSGGGGGGGGGGPASCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVILTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVFCGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSTADTEFADGSTTGERVLMKSPSPALHPPQKYKDRGILHPKRSTDDRSDQSSVKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPIRYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESSMVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQVGEQLLQLWERLPLGEKTTSD
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
QHNSKTANTTTPRTAGAMMCMYVCRCIECNEEAYELHRDYSNGILKITICKSCQKPVDKYIEYDPVIILIDAILCKVQAYRHIIFNTKLNIHVKLCVFCLLCEAYLRWSQHQGTEQTSDPADIIRYAKEWEFYGMFGLAALELGVFLGGVLAFLCSVQGLLTTSLDPHLLLKALLLSSYGKLLLIPAVIWEHDYSPLCFSLIKLFVLTSNSQAIRVVLNSSKRLSVFTVFVGFLLETSAAYIIQKIQW
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.
Sequence:
MADENTSLGSLRSCAKVLTEYATKGEFIVEVIGCRRLQENLEILTELLKCQENRTSLPESVFRDASCLLEAVLQHLDSSPPDGWSQGVLGTSTECFRFLRNSCVSCQANQLRVLNADLVPTTSAIVSLLAKQPELSNGSLEAAELVVQVSSSQMLALRCAVQLLGNLSSGNPSSQEVVWQAAYPDVFLSALGCPDPTAAGYCCMVIHVCLNETTMQQLVLDTKGRLLVQTVLDLCERQPDLDWGLLLVTDKFLMSKFFLPNVYSTLPLETRIILLDIISAKIGESESSGPGKEEEQFLPVFVLEFLAAEFQENFQTILSVGENTENLEAVIIMKLLKVLCLGTGQREKYIELVRMESLLESGVELLRLTTAAGKLGDNIFSQSQKLAPPDSPDDVHPVHGLKRDLIRLLGNMCFQNTSNQDKVRELEGIPLILDHCNIDDHNPYISQWAIFTIRNLCEGNHDNQAVIAGLEDKGLADNVALNDFGIEVTEDDGKFVVKSADK
The following text describes a protein:
Function:
Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme.
Domain:
Gln-173 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
Sequence:
MVPSREALLGPGTTAIRCPKKLQNQNYKGHGLSKGKEREQRASIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVYVLVMSVFAECLLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDNIFVKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGREKRVGGFDLMWNDGPVSREEGAPDLSGMGNFVTNTHLGCVNDRKKQLRQLFCSLQVQKKASS
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
PLKASERLLFKPISAVSSGLEASITEPNVISVKNVEIVVESQDDDKIQVRVDLLGKETQTVFDKVLRSLARSAPPVPGFRREKGGSLFIIINFCLMCMGTSAGKTTKVELFSFVPTDFLLQILGEARVTNFVIQEIVSSTLADYVKKENLTVKENKVNTIQTAEELKSVFVPGKDFGFNATLELEKPTEEEEDAEKKTMKKKKQQIKMNSFSSLIV
The following text describes a protein:
Function:
A flexible structure which links the flagellar filament to the drive apparatus in the basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MMRSLYSGVSGLKNHQVRMDVIGNNISNVNTHGFKTERVTFQDMISQELRGASEPKENIGGVNPQQVGLGSLIAAIDKIMTQGSLQTTGKNTDVAISGEGFFIVKDGDKQFYTRAGAFNLDKNGYYVNPANGLKVQGWNSRLDDKGNKYINSAASIEDIIIPVYSKEPARATSQIDFKSNLNSSAPAVPPDATQEEITAMINDPDPKMRRGHVTTINTFDDQGIQREFKMEFYKVRDNTWKARLSMTDSTQLSVDVSGTGGQNTQLPGNTELEFGFTPDGKLVYVSDGVDSMNSGKLNAKVSFRIPGNPAIQNFDLNLGEAGMVNGITQFSSDFTTKAVKQDGYTMGYLESFSIDNSGTITGVFSNGVRQPLARVATAVFNNPAGLDKAGDTMFSYSMNSGEPNIGEAGVQGRGKINAGLLEMSNVDLSDQFTDMIVTQRGFQANSRTITTSDQMIQEVLGLKR
The following text describes a protein:
Function:
Positive brassinosteroid-signaling protein.
Subcellular Localization:
Nucleus.
Sequence:
MNSHDIDDQLEADVYSNLPSRNDSSTGRRNRNSCRSKHSETEQRRRSKINERFQSLMDIIPQNQNDQKRDKASFLLEVIEYIHFLQEKVHMYEDSHQMWYQSPTKLIPWRNSHGSVAEENDHPQIVKSFSSNDKVAASSGFLLDTYNSVNPDIDSAVSTKIPEHSPVSAVSSYLRTEPSLQFVQHDFWQPKTSCGTINCFTNELLTSDEKTSASLSTVCSQRVLNTLTEALKSSGVNMSETMISVQLSLRKREDREYSVAAFASEDNGNSIADEEGDSPTETRSFCNDIDHSQKRIRR
The following text describes a protein:
Function:
Acyltransferase with broad-specificity, that mediates the acylation of lysophospholipids to produce phospholipids (glycerophospholipids). Converts lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity), lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity), also lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphochethanolamine or LPE) to phosphatidylchethanolamine (LPEAT activity) and lysophosphatidylglycerol (1-acyl-2-hydroxy-sn-glycero-3-phospho-(1'-sn-glycerol) or LPG) to phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) or PG) (LPGAT activity). Has a preference for unsaturated fatty acids of at least 16 carbons such as oleoyl-CoA ((9Z)-octadecenoyl-CoA) and palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA). Glycerophospholipids are important structural and functional components of cellular membrane, acyl-chain remodeling regulates the molecular species distribution of glycerophospholipids which can affect membrane fluidity and curvature. Essential for fertility and viability together with Nessy protein (Nes).
Miscellaneous:
MISCELLANEOUS: 'Oysgedart' is a Yiddish word meaning skinny, chosen because of this protein's role in phospholipid synthesis.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MLEPPKFIENDCYNGSRTFTWLADMVGLSVDLVNFLICQISALFLASLFRSMLHPSKVSSKLRHTFALSIGLAFGYFCFGQQAIHIAGLPAICYIVIRTQDPRIVQRAVLLVAMSYLLCVHLMRQLYDYGSYALDITGPLMIITQKVTSLAFSIHDGFVRGDEELTKAQQYHAIRKMPSALEYFSYVWHFQSILAGPLVFYKDYIEFVEGYNLLSTPPGNGNLDSSKREVVLEPSPTKAVIRKVVGSLVCAFIFMKFVKIYPVKDMKEDDFMNNTSMVYKYWYAMMATTCIRFKYYHAWLLADAICNNSGLGFTGYDKDGNSKWDLISNINVLSFEFSTNMRDAINNWNCGTNRWLRTLVYERVPQQYGTLLTFALSAVWHGFYPGYYLTFATGAVVVTAARTGRRLFRHRFQSTQVTRMFYDILTCLITRVVLGYATFPFVLLEFMGSIKLYLRFYLCLHIISLVTIFILPKFIRGERRLRTSNGNGNVRLSGSGNTKDAVTTSVESTAALTAGNDLNEDKEEDKHAQCKVHTPTQQQPAAGPHKTTVEQPTEQPNNVNLRSRPQQQQPHLEKKAMPPTCARDAVSVPHDQCEMDQLSSKLKEKIEAETKNIEEFIDKTVTETVSGIVEFKNDLMRDIEFPKLKLPGSNGAISLDSSNGGGLRKRNISSVHDNGTDPGHATADLHPPLEENGAAFLKKEIEVINAVVQQAVPAVLSNGHAK
The following text describes a protein:
Function:
Mechanochemical GTPase component of both plastid and peroxisome division machinery. Required for the last steps of plastid division specifically in mesophyll-cell, when the narrow isthmus breaks, facilitating the separation of the daughter plastids. Necessary for peroxisome activities. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency.
Subcellular Localization:
Cytoplasm. Plastid, chloroplast outer membrane; Peripheral membrane protein. Peroxisome. Cytoplasm, cytosol. Note=Plastid equatorial positioning (in a discontinuous ring shape) mediated by PDV2 in complex with ARC6 and dissociation from the outer envelope membranes (OEMs) is triggered by PDV1; this localization with OEMs is repressed by phosphatidylinositol 4-phosphate (PI4P). Dynamic subunit exchange within chloroplastic DRP5B rings with a cytosolic pool during chloroplast membrane constriction in a GTPase activity-dependent manner.
Sequence:
MAEVSAKSVTVEEMAEEDDAAIEERWSLYEAYNELHALAQELETPFEAPAVLVVGQQTDGKSALVEALMGFQFNHVGGGTKTRRPITLHMKYDPQCQFPLCHLGSDDDPSVSLPKSLSQIQAYIEAENMRLEQEPCSPFSAKEIIVKVQYKYCPNLTIIDTPGLIAPAPGLKNRALQVQARAVEALVRAKMQHKEFIILCLEDSSDWSIATTRRIVMQVDPELSRTIVVSTKLDTKIPQFSCSSDVEVFLSPPASALDSSLLGDSPFFTSVPSGRVGYGQDSVYKSNDEFKQAVSLREMEDIASLEKKLGRLLTKQEKSRIGISKLRLFLEELLWKRYKESVPLIIPLLGKEYRSTVRKLDTVSKELSSLDEAKLKERGRTFHDLFLTKLSLLLKGTVVAPPDKFGETLQDERTQGGAFVGTDGLQFSHKLIPNAGMRLYGGAQYHRAMAEFRFLVGAIKCPPITREEIVNACGVEDIHDGTNYSRTACVIAVAKARETFEPFLHQLGARLLHILKRLLPISVYLLQKEGEYLSGHEVFLKRVASAFNSFVESTEKSCRDKCMEDLASTTRYVTWSLHNKNRAGLRQFLDSFGGTEHNTTSGNAIGFSLPQDALGGTTDTKSRSDVKLSHLASNIDSGSSIQTTEMRLADLLDSTLWNRKLAPSSERIVYALVQQIFQGIREYFLASAELKFNCFLLMPIVDKLPALLREELENAFEDDLDSIFDITNLRQSLDQKKRSTEIELRRIKRIKEKFRVMNEKLNSHEFAQNLKAPSVQH
The following text describes a protein:
Function:
Acts as a transcriptional activator (By similarity). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development.
Subcellular Localization:
Nucleus.
Sequence:
MLSSPVASTPFSVADILRLECQQKDSKTLSQWELHRNPVKPRYLRMNQESGWFESSDRAQAVPFRCTWETVLEMGSNPVGEPQTPPGTISRLGARNPMTDRGVGNLSGDMRRGGPVSTRTRPQRKSRVLFSQAQVLALERRFKQQRYLTAPEREHLASALQLTSTQVKIWFQNRRYKSKSQRQDQTLELAGHPLAPRRVAVPVLVLDGKPCLDPDVAAFLGPYKATSPYSCFGGYAGTPYDASYASRCTSASAGPGPLTPLASSGFSPGGQSAAPQGHLPATPQGVTAW
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MPAASTTLCVQCQTEASKYTCPACKARTCSLACTRAHKSGDRSSSAAACSSSRYGSTTCVAASGSTSTPHATTTCSGGTDFIPMTQYTESHMLQDYLFLSSISRTTSETGRQIVSMNLLPAPTTDGAKHQVCASATGAPRLTNQQRQRDQLIKQLHYRKFKVMVLPEGMARRKSNMSQFQPKDKKFGLTVQLKLPHHSSRSKPDEPEPEPEPERDSWLLHKQDCLETVEAVVLTELQTRSFANKKDISRLRATLHLSSKDVRSWILSAAMISTCGLAMPSIATNVDKTLAKHGEDHLLLLHAFPQEWTLLVPAYSARLANESTSRYLDWWARKRKWEESNPELAAQQSDEQRKEASAGREGRRGISRIQRERGEQTEHAGSRNGTRIHADARPEQVAQRGMQKPSADNTTTTTTASTMVSSAYPSPAPTVASQGLISSNLLSMLSQRLGRQPQPQPSTTLSASPPPPSTTASTQRAPPTAATQSRSSPAQPAQPAQPESARSILVHITSPRHTTLSWLLQTLPEGYSVVEYPELRIVAAERLERMQNGGVQVVPLMGEGLQANGAPKDDEPRPEHTGSTVTHMTNACARGLGGLLAGYDSESDCEQQPEQDQIRPDPIHTVELAQHADRVDHQVAQPSTLASLARQHGFT
The following text describes a protein:
Function:
Bifunctional nuclease with both RNase and DNase activities. Involved in basal defense response. Participates in abscisic acid-derived callose deposition following infection by a necrotrophic pathogen.
Sequence:
MSSFALGLGASGALAPCRQSPSRSQVPIHCTNSLAAARSSALASTSSSVSSGGVGAARTAACSLRRGKAAIRGGCSIAKASAGEGALFPFAESDYHRVVLLDRQPYGPMKILPATDQSAGTYSGVLVFQRDADLTLTPDTNILEIFVAGDTATNIYTQLQNTKSARPMVHDLMFNMLTRAAQTNGRQWQLLRVAIVALENDIFVGRLFFGDPATGVVAWDCDCRPSDGVYLSMRSGCPFYVAQIVWDVAAVPIRASKVHMIAVHEAHMAAVQQQQQQHGHAHQQQQQPAPQQQQQSGAASSSGGGNGTVFPRASSGAWGAQQEGASSIVPPPSPPSASDDYTQLKPDDMDAIKLLKRELAVAVREEDYAAAIRLRDHPFMQMYRRIEALNHLGRGEEATRLQNELVAMVQRTHAEATY
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Sequence:
MEESRAQGQPEAAATADRNGEAKTVFVGHRTLAVPAQVLGILAGGKPCAEAVAGAEVVVVLSHSPFLAEGSGQACDQGVLAAENLVVAVEAVRRQGAVYLHKGKVQRGELKVGETVQAQVNAIRRRLVQTHHSAVHLLHAALRRVLGAEIEQRGALAASDRLRFEFAAPQSLGGQEVARVEQVVNLWVLEGHPLGVETMPAEKARQIGALPFPGERYGEQVRVIGTPEIGFELCGGTHVSNTIEIGPFKIVGHSEPEAGVRRLEAVAGLALLDYLRAHEQVTRILGEQFKAPLAQLPERLGAVLTQAQWAISQVEDLKVALALARCEACLGEVEQYGQYRVLVADLGDTEPAALAAAAEGTLSKLGEGTVVLGSSPGADAVAFTVAFSPKAVGLGLNAGQFAAALAQLTGGGDTQGNAQIAQAAGRQPTRLKAALDLAFAKLYDTFNDT
The following text describes a protein:
Function:
Sperm protein required for fusion of sperm with the egg membrane during fertilization.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Note=Following the acrosome reaction, relocalizes to the equatorial segment.
Sequence:
MWRLALGGVFLAAAQACVFCRLPAHDLSGRLARLCSQMEARQKECGASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSWLRKTKLPEYTREALCPPACRGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGAFLLLGVLSLLVESHHLQAKSGL
The following text describes a protein:
Function:
Protein kinase that may play an important role in cellular stress response. Plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Endoplasmic reticulum.
Sequence:
MTVKTETAAGASTLTYSKMRGMVALLIAFMKQRRMGLNEFIQKIATNSSYSCKPSEVQSILNISPPQESELLNENSSPPPSHSQQINLGPSSNPHAKPSDFQFLKIIGKGSFGKVLLARHKADEKFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSIQTTSRLYFILDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEPNGITSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARNLLEGLLQKDRTKRTGAKTDFMEIKNHIFFSPIDWDDLINKKITPPFNPNVSGPSDLQHFDPEFTDEPVPNSIGQSPDSILITASIKEAAEAFMGFSYAPPMDSYL
The following text describes a protein:
Function:
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCISADGSQLPLFRMNISQCDLPEISVSHANLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVHYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFVSFYEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MEAQALDEHARIYVDAGWRGIFVVPLSPFGHDACQNRGGNVPAARRIRSGGRRGKNDDGDRTDDAAAMGTAGLNSDAAFEKESNRNWPKVSCISAHSCSPLTGGPAADQAYEAQQKLSSLLPRKGPRKFEGMLGNLPEVESAHPNPPAPPPAPPTASRRGGRRPGGLSRGAALSFRADRPSPSPAAMICAISGEVPDEPVVSKKSGLLFERRLIERYVEDHGKCPVTKEELTMDDIVPVKTNKVVKPRPLQAASIPGLLGIFQNEWDALMLSNYSLEQQLHTARQELSHALYQHDAACRVIARLKKERDEARTLLAQAERQIPASVAAAAPAAVVSNGKRATEDEIGPDGKKIRPGINPVMIDELTECNTMLSAQRKKRQVPPTLAPIDALERYTQISSHPLHKTNKPGILSMDIHPSKDIVATGGIDTNAVLFDRPSGQILCTLTGHSKKITTLKFVPRDGLFVTGSADKTVRIWQESENGNYNCIHTLKDHTAEVEAVTVHATQKYFVTASKDNSWCFYDISTGSCLTQVGEASGQEGYTSASFHPDGLILGTGTTDAVVKIWDVKTQSNVAKFEGHVGPVTAMSFSENGYFLATAAHDGVKLWDLRKLRNFRTFSPYDSDTPTNAVEFDFSGNYLAIGGSDIRVHQVANVKVEWNLIKTLPDLSGTGKVTSVKFGADAKYIAVGSMDRNLRIFGLPGDDQMEESNTAAE