lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-dependent chromatin-remodeling factor. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Enriched at sites of mRNA synthesis.
Sequence:
MKMKIQKKEKQLSKLRALNHSPMSDASVNFDYKSPSPFDCSPDQGENIEEAANHCLPQKDFYTTEEEADTLFSRKLMSHNGMEDNGGRGTGVKKKRKKKEPGEQEGTKASKDREPKPKRKREPKEPKEPRRAKEPKRAKEPKEAKQKDGVKKPRKPREASGTKEGKEKRSCTDCGPRTKPKKASKDQGPTPVERKKKGKRKNETTVESLELDQSLPNPSLQSPEEPSESADSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDDANIIEKILASKTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEKDPRIAQKIKRFRNKQAQMKHIFTEPDEDLFNPDYIEIDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEEDVDPAKVKEFESLQILPEVKPVERPASDAWQKLETSREYKNSNRLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSIAFLSEIFVRGIHGPFLIIAPLSTITNWEREFRTWTEMNAIVYHGSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSCVVIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMMELRKCCNHPYLINGAEEKILEDFRKAHSSEASDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAILQDINRKGSTNGVQQLSKMEVEDLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKIAELDTEANNEKESLVIDRPRVRKQTKHYNSFEEDELMEFSELDSDSDERPTRSRRLSDKARRYLRAECFRVEKNLLTFGWGRWKDILTHGRFKWPLNEKDMEVICRALLVYCVKHYKGDEKIKSFIWELITPSKDGQVQTLQNHSGLSAPVPRGRKGKKTKNQLLLPELKTADWLATCNPEVVLHDDGYKKHLKQHCNKVLLRVRMLYYLKAEILGEAADKAFEGTPARELDVLLPDIDYVEIPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLEKVGMPDEKSLSAEQGVTDGTSDIPERGNIDKEDSAEDKVDGLQKQTASPSDGSDGIFGEKKDDSQAVSSALTARLRRLVTIYQRCNRKELCRPEILGPGNQGYWVQEEVFRRTSDMDLINKEAQKRWTRREQADFYRTVSSFGVVYDQEKEAFDWTQFRAISRLDKKSDENLEHYFHSFVAMCRNVCRLPTWKDDGPPDASIYVEPITEERAAKTLYRIELLRKVREQVLTCPQLHERLQLCRPSLYLPVWWECGKHDRDLLIGTAKHGLNRTDYYIMNDPQLSFLDAYRNYAQHKRTDTQAPGSLCCLYQGNSKLYESLTYTPMSRTSESLESEPENLVKMDSRDDHLCLPEAGLPDITCENFVSKVQEVISLDHDESLLPESLENMMYGKTGLSQEPRSFQEAPSTNMQSRKKTVTVSASRDESCQLPGIEAEITSASSLMSSLEAGVAKMNIKNGKHLLVSISEEGEPCCSETGRSPESRGRLEARCLASPTLDTGHESGFVDLCSLSVYDSKRNFSSDQQLIDLLENKSLENKLILNQSDEEEEENEKETLAIVASTTEKPAVLDFTQPTASIPRGKNLSFHQDEAKKGRLEVGSKTPGPQRAFPPSANQCHCKHIERWAHGLGSEESEGEKPKAYEPDPYRSKANNTTVEGEPAIIPTEPFKLKHELLKEPWKESSEGGKSFSMYVPEGSEPKSEEMDFENKDDYEKDGACHSQDYPGKYSEEESKSSASGIAGDLGEEAQEVRAPTIAQLLQEKTLYSFSEWPKDRVIINRLDNICHVVLKGKWPCSHQYEPSGALPTPVLSSSAGSRSSLSEPEATEHSFSNGAALAAQIQKESFLAPVFTKDEQKHRRPYEFEVERDAKARSLEEYSASHGRPPIVLNGWHGESAIDLSCSSEGSPGATSPFPVSASTPKIGAISSLQGALGMDLSGILQAGLIHPVTGQIVNGSLRRDDAAMRRRRGRRKHIEGGMDLIFLKEQTLQAGILEVHEDAGQTTLNTTHPEGPGAASSASEPTAAASSQAEKAVPSKSLLDWLRQQADYSLDVPGFGASFSDKPKQRRPRCKEPGKLDIGSLGGEERVSAVPKEPGLRGFLPESKFNHTLAEPVLRDAGPRRRGRRPRNELLKAPAIVADSPSGMGPLFMNGLIAGMDLVGLQNVRNIPGIPLTGLVGFPAGFATMPTGEDVKNTLSMLPMMLPGMATVPQMFGVGGLLNTPMATTCTTTASASLASTKSGASATEKTTEDELSGRDVKADSLVEDKPGPSPFSDQSEPTITTSSPVAFNPFLIPGVSPGLIYPSMFLSPGMGMALPAMQQGRHSEMAGLETQKRKKKKTKGDNPTPEPASVCEREPGSDQNCTESSVTVSPEREHVAQAREEGLKDSNDDTN
The following text describes a protein:
Function:
May regulate epithelial calcium transport by inhibiting TRPV5 activity.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=Apical domain of kidney distal tubular cells.
Sequence:
MSADVSGTESGSESGPEPEPGPEPGPESRPESRPKPGPGPEPRPESGPEPGPRSGLRRGPKQGSERSQLCPEHFEPLSWFCLSERRPVCATCAGFGGRCHRHRIRRAEEHAEELRNKIVDQCERLQLQSAGISKYMAEVLQGKNQKAVVMASAARDLIIQRLSLVRSLCESEEQRLLEQVHGEEERAHQSILTQRAHWVDAVQKLDTLRTNMVDMITHLDDLQLIQREQEIFERAEEAEGILDPQDSEKLSFNEKCAWSPLLTQLWAASVLGSLSGVEEVLIDERTVSPLLHLSEDRRTLTFIAKKSKVCSDEPERFDHWPNALAATAFQTGLHAWIVNVKHSCAYKVGVASDQLPRKGSGNDCRLGHNAFSWVFSRYDQEFCFSHNGYHEPLPLLRCPAQLGMLLDLQAGELVFYEPASGTVLHIHRASFPQVLFPVFAVADQLISIVRGPLATVRLDSPPHHPCRSGHASR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MESEVSTKKQLLSLVDDVDLVIRLISDSAIGNRRKTENVKNFCILPEYLLLQKNKKLADLTEVACQQQKLEVKVKATRAEIAMKDTEIKCLQKHLKAAEQLLGTALHQAKEKLKSFDQANKGSVMSEDIIKYAHKISASCSTAAPLNWTPGDQRRPYPQDIEMRCGWLGQINNSDMNVKDPMLKPPAQLGTDGIQMPSFSIYSTGVTLLMLGFGAFETGNQSMDMSTFTDGRSTEDVDVMSSDSSSSDSSDSSGVND
The following text describes a protein:
Function:
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Domain:
The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.
Sequence:
MFRQVSVRALRRAAGRSVCASRAQMVRHSSTLGGGKGSYNLDMPALALAAGVTLLAGYMVYPRAPKAKQAAVQSVAPVNENVEQASASLQASAPVQATSESAEAGEEEAYGEESGAVNEEAAGEPEEAAAEVGETQAEQAPAVETEQAAEAEQAAEAAAEDKASAGEAAQGQQGAYNPDTGEINWDCPCLGGMAHGPCGEEFKAAFACFVYSEAEPKGIDCVEKFQVMQDCFRQHPEHYAEQLESEEQAVRETEAAAESAKSDEGH
The following text describes a protein:
Function:
Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGEEFTFIMLLSGSWNAITLIESTLPLKGAELDLLIVMKRTTARPRPPMPASVWVQVDVADSPHLIERFTALFDAHHMNIAELVSRTQPAENERAAQLHIQITAHSPASADAANIEQAFKALCTELNAQGSINVVNYSQHDEQDGVK
The following text describes a protein:
Function:
The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MHMNPTPLPHSEDDGVMFASIGQTTLALTEPPSALHATDTLDDVFGSEDVQGSTSFTTEPSDMRRLQSEHTTAGYREGVTVAKAASVQAGFDEGFGLGATLGLSAGEIVGVLEGLAAAVPGDERLAALLGEARGDFSARSIFGATYWDPNGTWTYPVPGQDGGDVIFRDVVEAHPLIAKWRVVLNEQIQNWGVRCDFFAEDQVVDEEVVSQKKLGNPATALKAATSTAPATQSRMSDALQW
The following text describes a protein:
Function:
Inclusion membrane protein probably involved in early modification events of the chlamydial inclusion.
Subcellular Localization:
Secreted. Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane; Multi-pass membrane protein. Note=Secreted, probably by a type III secretion system (Probable). Localized in the inclusion membrane. Inclusion membrane staining is punctate. The C-terminus faces the host cytosol.
Sequence:
MGDVMIQSVKTESGLVDGHHGSCDSLGCVVGALAKVAKLVVALAALVLNGALCVLSLVALCVGATPVGPLAVLVATTLASFLCVAYVLFIAAKDRGWIASTNKC
The following text describes a protein:
Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MTMLLIKKRNQMATFELYRRSTIGMCLTETLDEMVSSGILGPELAIQVLVQFDKSMAEALDNQVKTKVSIKGHLHTYRFCDNVWTFILQDALFKYDECQENVGRVKIVACDSKLLVQ
The following text describes a protein:
Function:
Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). PAssociation with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). ositively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allosimulatory ability (By similarity). Negatively regulates B cell proliferation (By similarity). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGAPEPSWCFLFLPVLLTVGGLSPVQAQSDNYPGCECSSVSPGVLAGIVLGDLVLTLLIALAVYSLGRLVSRGRGTADGTRKQHMAETESPYQELQGQRPEVYSDLNTQRQYYR
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSIFRSEKMSLYQLFLQNESAYRCMSELGELGCVEFRDLNSEATAFQRTFSAEVTRCNEMERKLRYLEAQIIKEGVKIDELDDMPLAPLPKEMVDLEAALDKMDSELREINANNEALSKNFGSLTEMKFTLQNAENFLGDVRTPEKNPSGALTLEDGLTQQQAMQRFRFVTGVISQERAPGFERMLWRAGRGNIYLRIAPLPEPLKDPVTGNDVLKSVFIAFYQGDQLKGRVKKICEGYHAALYPCPESAAQRRETSIGVFSRLQDLTTILDQTKQHRHRVLEASAKHLRSWVVKVRKIKGIFHSLNMLSVDVTSKALIAECWIPDADVPRVRLALKQASEASDSVFPPILNELPTNAKPPTYFRTNKFTYGFQALVNAYGIANYREVNPGLYTIITFPFLFAVMFGDGGHALIVTMFASWMCLNEEKLSKIKEEVFSIIFGGRYIILLMGFFSIYTGFIYNDFFAKAFNIFGSAWVVNYPSERHPGGEYLIGEGSMESAMLVPDRHYDDPYPFGVDPVWVIAENKIVFLNSYKMKLSIIFGVFHMSFGIFLNLWNFTYFKRRLAILVEFLPRILFFWPLFGYMMSLMFLKWVKYGANKEDRVLKSDCAPSILITFINMMLLSYGEDKTKPPNEECKTVFMFGDDEGVTQKTLQIAFVVIAVLSVPVLLLGTPLQFKMKENRMKKARASYSNDSGSSRSDGNEPEDREPIVNSSTMNVESGGKHPEPIGDYDQNQGGSHDDEHNTFGDVMIYQSIHTIEFVLECISHTASYLRLWALSLAHSQLSEVLWFMVLRIGFKALPGYYGSISIFLTFGFWAGATVSILIAMEGMSAFLHTLRLHWVEFQSKFYKGEGVKFHAFHFKRVTDDVKDD
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions (By similarity).
Domain:
The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae.
Sequence:
MEENCDSTENPHSQGRQNATKCGWLRKQGGFVKTWHTRWFVLKGDQLHYFKDEDETKPLGTIFLPGNKVIEHPCNEESPGKFLFEVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVVPYAKYEDFLSCATLLSKEEEAGVKELTKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSAQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDRLFPKDTEPQSKPQEGPNSNNNDGHKKVTMGQLQNKENNNTKESPVRRCSWDKPESPQRSSMDNGSPTALSGSKTNSPRNSIHKLDVSRSPPLTVKKNPAFNKGSGIVTNGSFSSSNAEGVEKTQTTPNGSLQARRTSSLKSSGTKMGTHSVQNGTVRMGILNTDTLGNSLNGRSMSWLPNGYVTLRDNKQKEPAGESGQHNRLSTYDNVHQQFSLMNLDDKHSVDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPGDYENKSDRRSVGGRSSRATSSSDNSETFVGNTSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMLNLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGDLTVEPRRSERGNTIWIQ
The following text describes a protein:
Function:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein.
Sequence:
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLTASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYDPYTQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHTWKVFKYFAKDCATSFPNITSGQAQGVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLGDTLLGRRQNDSLDKYYYALYEMVVRGSCFCNGHASECRPMQKVRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAAELQDNACRSCSCNSHSSRCHFDMTMYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPLLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNMCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLNFYLYEAEEAMPLQGLAPLGSETFGQSPAVHIVLGEPVPGNPVTWTGPGFARVLPGAGLRFAVNNIPFPVDFTIAIRYETQSAADWTVQIMVNPTRGSEHCVPKTSQSKPQSFALPAATRIMLLPTPICLEPDVQYSIDVYFSQPLERESYTHSHILVDSLGLIPQINSLENFCSKQDLDEYQLHNCVEIASAMGPQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKSLVVGRCCDRCSPGSYGLGHHGCHPCHCHPQGSKDTVCDLVTGQCPCHGEVSGRRCDRCLAGYFGFPSCRSCPCNGFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCPCNNNIDVTDPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPVECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCHLCFDQWDHTISSLSKAVQGLMRLAANMEDKRETLPVCKADFKGLRENMSEIERILKHPVFPSGKFLKVKDYHDSVRKQIMQLNEQLKAVYEFQDLKHTIERAKNEADLLLEDLQKEIDLQFSVLNASIVDSSENIKKYYHISSSAEKKINETSSTINTSANTRNDFLTILNTLTSKGNLSLEKLKQIKIPDIQILNEKVCGDPGNVPCVVPLPCGGAVCMGQEGHRKCGGAGCHGSLTLSTNALQKAQEAKSVIRNLDKQVRGLKNQIKNISKLAEVSKNNALQLRGKLGNTRNQSDSEEEKLNLFIKKVKNFLLEENVPPEDIEKVANGVLDIHLPIPSQNLMDEVNKIQKLMQLCEDYRSDENRLSEEEDGAQKLLVKAKAAEKAANVLLNLDKTLNQLQQAQITHGRANSTITQLTANITKIKKNVLQAENQTREMKNELESAKQRSGLEDGLALLQTKLQRHEDHAVNVKVQAESAQHQAGSLEKEFVELKKQYAVLQHKTSTTGLTKETLGKVKQLKDAAEKLAGDTEDKIRRITDLERKIQDLNLSRQAKADQLRILEDQVVAIKNEIVEQEKKYATCYS
The following text describes a protein:
Function:
A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms. Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death.
Subcellular Localization:
Lipid droplet. Cell membrane; Lipid-anchor. Cytoplasm. Mitochondrion membrane. Nucleus.
Sequence:
MGSKVSVEESVRVVIVGGGFAGIAAATQLKSFGIPFVLVDLKDAFHHNVAALRASVESGFARKTFISYKDTFQDNFIQGKVVGINLQTQRVILESNEELQFSHLIIATGSNGPFPGKINNVISKDQAIQVYEDLVKEIQKAKHVVVVGGGSAGVEMAAEVKTDYPEKEVTLVHSKVALADVQLQPKVRRTVKEILLSKGVRLILAQKVTNLDQVTSNVAQENTVLQLDKNSEVVTCDLVLCCTGYKISSSSYSSAFGDKLAEDGALIVNDYLQVQGHANVYAVGDCAYINEPKMAYYAGIHARVAATNVRNSLIGKSLKTYKPGALSMLLSMGRNDGVGQFNGCYLGRFFVTMAKSRDIFVSKSWKEMGQTMPR
The following text describes a protein:
Function:
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPRKVVTCASYEARAYGVRAGMPLRTAARRCPEATFLPSNPAAYNAASEEVVALLRDLGYPVEVWGWDEAYLAVAPGTPDDPIEVAEEIRKVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRTVEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLLAKGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVVASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFELDRPVRLLGVRLELA
The following text describes a protein:
Function:
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSNCIFPSILFSELVVSHKGAEALVMVPKQRGVNVTAGEVGHFLSKDQREQTRKTVTISLLRSHQTGSTKSKQTPRTSSEKSSLKKLEAWNGAFLPQMAENEFLEEKTFKQHCAEFIKHSEEIGDGWEWRNSKDYSDGYMSKTHFQIKNGTSVTEQLFPQAEDDFELYSDDSEVAGISTASEVIRYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKEIWDDVHQFYKIRLLQEPWSTITQQEHPLLGQPFFVLHPCKTSEFMTSLLENSEKDNRNINYITSWLSIVGPVVGLHLPLSYAKAMSQPNTNTD
The following text describes a protein:
Function:
Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. The PCL7-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase. PCL7-PHO85 also phosphorylates MMR1 and YJL084C.
Miscellaneous:
MISCELLANEOUS: Present with 3390 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MELSSPSKKTTTSPINIPGGNRDNLIIGPHSHSFKTDPFSSNNSSLLSKISTNPSLESPFSSKSLLDCSPVQAVKKSLESEAKTHSLDEETNEQTDVKILNIADFPTDELILMISALLNRIITANDETTDVSQQVSDETEDELLTPILAFYGKNVPEIAVVQYLERIQKYCPTTNDIFLSLLVYFDRISKNYGHSSERNGCAKQLFVMDSGNIHRLLITGVTICTKFLSDFFYSNSRYAKVGGISLQELNHLELQFLILCDFKLLVSVEEMQKYANLLYKFWNDQ
The following text describes a protein:
Function:
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Subcellular Localization:
Host apical cell membrane; Single-pass type I membrane protein. Virion membrane; Single-pass type I membrane protein.
Sequence:
MEKIVLLFAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSSHEASLGVSSACPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYPQYSEEARLKREEISGVKLESIGIYQILSIYSTVASSLALAIMVAGLSLWMCSNGSLQCR
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MKEIDWANLSFGYMKTDYNVRINFRNGAWGELEVSSDEHLNLHMAATCLHYGQEAFEGLKAFRGKDGKVRIFRLEENAARLQSTCQGILMAELPTERFKEAILKVVKLNERFIPPYETGASLYIRPLLIGTSAQVGVHPAEEYMFVVFVTPVGPYFKGGFSTNPYVIIREFDRAAPHGTGIYKVGGNYAASLRANKKAHDLGYSCEFYLDAKEKKYIDECGAANFFGIKDNTYITPKSSSILPSITNKSLMQLAEDMGIKVERRPIPEEELETFEEAGACGTAAVISPIQRIDDLENGKSYVISKDGKPGPICTKLYNKLRGIQYGDEPDTHGWVTIVE
The following text describes a protein:
Function:
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
Sequence:
MRNKILVVGPPGSGKLTMLKELMGTVSPVTGSHAGIIEEYHIKNKYYEARVGVWVDEFLLEGDSTQLSADRIEGLVSLPEWTESFCSNEAKEVRDSIKAVVFTLRHGSDAAHLEPQLKVLEQLVGMLDNDNWDGSLICLQKGHVSPELAAQLDAVCFDYGFEYISHLVSEQGETTGYDRLQEAIEVLGWETQDEAKETPVPDPILTSPTLMARSSPSLHASSFDARSLSLSPADSDMLKGLLNDDLDNFQNIFDKLKIARNSNLSDEQRTRLANDLAEQLIGGEVPGH
The following text describes a protein:
Function:
Component of the yop secretion machinery.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGEKTEQPTPKKIRDARKKGQVAKSKEVVSTALIVALSAMLMGLSDYYFEHFSKLMLIPAEQSYLPFSQALSYVVDNVLLEFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIKKINPIEGAKRIFSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLPTCGIECITPLLGQILRQLMVICTVGFVVISIADYAFEYYQYIKELKMSKDEIKREYKEMEGSPEIKSKRRQFHQEIQSRNMRENVKRSSVVVANPTHIAIGILYKRGETPLPLVTFKYTDAQVQTVRKIAEEEGVPILQRIPLARALYWDALVDHYIPAEQIEATAEVLRWLERQNIEKQHSEML