lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, nbn acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits mre11 and rad50 components of the MRN complex to DSBs in response to DNA damage (By similarity). Promotes the recruitment of PI3/PI4-kinase family members atm, atr, and probably DNA-PKcs to the DNA damage sites, activating their functions (By similarity). Mediates the recruitment of phosphorylated rbbp8/CtIP to DSBs, leading to cooperation between the MRN complex and rbbp8/CtIP to initiate end resection (By similarity). The MRN complex and rbbp8/CtIP are also required for chromosome alignment during metaphase (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Nucleus, PML body. Chromosome, telomere. Note=Localizes to DNA double-strand breaks (DSBs); recruited to DNA damage sites via association with phosphorylated proteins, such as phosphorylated H2AX.
Domain:
The FHA and BRCT domains specifically recognize and bind phosphorylated proteins; The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex; The FxF/Y motif (also named EEXXXDDL motif) is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response.
Sequence:
MWKLQPTESGGESVILLAGQEYVVGRKNCEILLTNDQSISRVHAVLTVTEQAVTLKDSSKYGTFVNGEKLESGSTKTLQTGYKITFGVFQSKFSLEKECIVVCSSCVDNEGKVTLSQDIRSVGGRLVSSWTSDCTHLVMPTVKVTIKTICALLCCRPIVKPAFFSALSKAVQQKLPLPKAERFRPQIDEPSLARDDVDLSARPERKSLFKGKTFLFLSSKQMKRLSVAVSCGGGVSQLLDEGALPVSLLESSSTCVLDMISGNSQPVISPASKKWLDSVGQILHRKGLRFITESEVGLAAIHVSNQTYCNPCSSLQSESVKTNPVFASATLSQSTAVDETALAAPSQNITAYVVNTEISQDQSRMVTSGISAVGETPEKTNPTQKASTTNKPLSLGQEPSSTRIVQETVMSSESFSVVESEQKMKKGSVVSARGRVEGPVKQKAPSSGNTTLKHSPQKQTALTSFFQPSSKKRPRESSASSVQPEPKFFKKDIKDNEDDIQQSFSVNRSHKTSSEETSLGQACGTGQNSSSKKRKEPEQDTLLGAEEPTAADDLEMSLEELEFLMSDEMDEPPQTAANKKQRLESGLTSKINSEQLSNQQEVTESKGRKGEKNQQSSSSNIQSMQLDRAGPAVTNQDTQTQSKRSPPDLEAHSSANKGPSKNKTPELEEVKKEEVSFVVNSRPQNGISQTSEAVLKQEMQASTSNSGPKNDPDLPRKLLQVQFMSLTVNNSSRSRPGPLQTHNPNDKNVKRFRKKNVPGFDGLPKIIGGSDLVAHNRSKHSELEEWLRQAAEEEKLNEREETLGDDLFRYNPRPAKKR
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
Sequence:
MPELPEVEVVRRGLERWAAHRTVADVEVLHPRAVRRHVAGPDDFAHRLKDHRIGTPSRRGKYLWLPLEDTDQAVLAHLGMSGQLLVQPHETPAEKHLRIRVRFADALGTELRFVDQRTFGGLSLHDTSADGLPDVIAHIARDPLDPLFDDEAFHHALRRKRTTIKRALLDQSLISGVGNIYADEALWRARLHYERPTATLTRPRTTELLGHVRDVMNAALAVGGTSFDSLYVNVNGESGYFDRSLDAYGREGMPCRRCATPMRRRPWMNRSSYFCPKCQRPPRVTP
The following text describes a protein:
Function:
May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate.
Sequence:
MKKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDFATINEVYKQFFDEHQATYPTRSCVQVARLPKDVKLEIEAIAVRSA
The following text describes a protein:
Function:
Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.
Sequence:
MSNEPPPPYPGGPTAPLLEEKSGAPHTPGRTSPAVMQPPPGMPLPSADIAPPPYEPPGHPVPQPGFVPPHMNADGTYMPAGFYPPPGPHPPMGYYPPGPYPPGSYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYICTYKRLC
The following text describes a protein:
Function:
Converts protoheme IX and farnesyl diphosphate to heme O.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MISRKGLGLAANFLHPIPSDKVAAVHTLHRTFSIQSTQCLPPWPSRSQTLAREMFAPCEGSNHRARKSLTWALFAPRCQKRSSHSIARQTGDTSVDSTRPFFSAHPTPYSPPFRTVYGAANAPVPELPDLRLPHPTSPAAPVSAYKPLPPLTWKRLLGVYSALSKRNLTILMTLTATTGLALSPLPLSIPLLLNLTVGTLLTSAAANTFNQIFESPIDAQTPRTRVRPLVTRRISPFHAAVFGLVCTVMGGAILWYGCNPTTAALGIGNLLLYSAVYTPMKRFSVANTWVGAIVGAITPLMGWTATGASLWPTSDQPLLLHTPWSDLPNLPNPLTPLTLFVLLFSWQFPHFNALSHMIRPFYALSGYPMLSVLSPRLNALVSLRHAVLLVPFTAILGPLSGCVDWSFALTSSVPNYFFVRDAWRFYKLTNEANARKLFFVSLWYLPAVLGLMLVHKNVMGWLDGRREAEEQEKVEMEVPVEGRS
The following text describes a protein:
Function:
May be involved in the unfolded protein response (UPR) during ER stress.
Subcellular Localization:
Secreted. Endoplasmic reticulum lumen.
Sequence:
MIVNKKYFLLICIIILISINCLVLAKDEIENFLKEGDDLVSKGKYDLANENYSNAIDLIGSDTQHPQYVSLLFKRAGIYHQKGKNILALSDLNRAIEANPDNIHARLKRAKIQSSLGRFEEAMDEYKRVLKIRPDNSQAKQQIEKLKKVEQQLEKVRDMVKVEKNYKDSIAILLDIQSVVSDLKEVRLMLCECFFQQGDHRKVLDETMTILKSEPSSVAALYWRGKTFFSMGEKEIAMKFLKEGLKFDPDNTNCRAMIKTINKFEKSTANAQELFNQQKYQDALGQIEDALEIEPNSPTHSTPLYLLKCKCLLKVKKGKESIEACNRALELDELNADALYNRAEAYMYEEDYQKALNDYNKAREHKPNDPQIHDGIRRAQKAQQMAKRKDYYKILGIQKSATPEEIKKAFKKLAIKNHPDKSTETDKEKAQQIYMDINEAYEALKDEEKRKRYDMGEDINDPHGGQGGQGGGFGGFGGFHGFQGFQGFQQGGGGGGFQFHFR
The following text describes a protein:
Function:
Has a role in nuclear division during meiosis II where it stabilizes the proper segregation of the spindle pole bodies. Also has a role in the formation and extension of the forespore membrane.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Prospore membrane.
Sequence:
MPKSSNLKMQRKGSLRENGLVKGLNKNKFSISKLKELSHADDSRKSHRIIRSGKSSGEAYKQAGKGLMNLGNHLSDWGAKSSNLSLNDISDKIGVLVSELGETEIEFVKAFNENRIKFKAIRAMEDSIAPSRAHRQRLISSIEREEERDPLSPKLTDLQNQLVRTEAENLVGEMQLDNTSREVFKSSFQGLMDAFQLRAQKQMTLSYYASQLAELINDEVAYPGDNPAAYSQKYATQIMHQCVESMARLLAPVTSETTEHVGSDCEFTRKSSSSVEFSDHSQDSGDPSQQNILQVKNVQAVLSIPEAESYKAQLLSSIAEEQKKKELQAKSTVFL
The following text describes a protein:
Function:
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQLSAAQTPQPKPADGNRALYGGKINRRITVRDITAAKERGEKWPMLTAYDAMTASVFDESGIPVMLVGDSAGNCHLGYETTVPVTLDEMTMLSAAVVRGTSRALIVGDLPFGSYQEGPVQALRSATRLVKEAGVGAVKLEGGERSHRQIELLVESGIPVMAHIGLTPQSVNSMGYRVQGRGEEAAQQLLRDAKAVQDAGAFAVVLELVPAELAAEVTRTLHIPTVGIGAGPDTDAQVLVWTDMLGLTGGRMPKFVKQYADLRKVMGDAAKAYAEDVVGGTFPADEHSVH
The following text describes a protein:
Function:
Inhibits contact coagulation pathway activation in the host by sequestering anionic polymers, such as polyphosphate and dextran sulfate, and thus blocking interaction of protein components of the pathway with negatively charged surfaces. Inhibits dextran sulfate-mediated autoactivation of host coagulation factor XII (F12). Inhibits dextran sulfate-mediated autoactivation of host factor XI (F11). Inhibits polyphosphate-mediated activation of host F11 by thrombin (F2). May inhibit dextran sulfate-mediated bradykinin generation in host plasma.
Subcellular Localization:
Secreted.
Sequence:
MKYLGLALISAVFLIGACQAETPSQKCEEKYKGNTDKISCLHHCKYQYYGFIDVNYNIAQSEIRKFSNVLMDYGVVDKSKKRELKKVMHECAKQVKKEARKDSHWLNCRTSINYYRCVLTSKLIGPQRFDKAIQDYDKTISV
The following text describes a protein:
Function:
Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in a process influencing telomere capping.
Miscellaneous:
MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein.
Sequence:
MSLSPHVENASIPKGSTPIPKNRNVSSIGKGEFLGSSSSNNSSFRMNHYSNSGQPSVLDSIRRPNLTPTFSYSNGVYMPESHRTSSFNDSYLPYDKNPYAKTTGSMSNKSNMKIKTKKNAINTNTRKSSGLIYTTKVDKELSSIDKVNDPNINGLVCAGKTHLGLYKFSPSDRSIKCVHDFITPNSNTSTRGTTSLLPKLSKRTRQNKFSTIADVKTGFNNYKNCIAVCNNSTAISIYDLNKSSSIDNPLITSLCEHTRSINSFDFNMVESNLIISGGQDSCVKIWDLRSNKSKSSNRSDISINTASDSIRDVKWMPGYNFASKNDQGSSTYGNLKSGYKFASIHDSGYLLKFDLRQPAQYEKKLNAHTGPGLCLNWHPNQEYIATGGRDGKCCLWFVGDNANAAENTVLNYGNSPSLHAPNTSLNNSGSLAFPKLTINTGYPVTKLKFKPAYSSNIYNSLLGISSMGDEAEVRIYSLARKYIPKHVLLSETPSLGLVWWDENLIFNIDKGTRINGWDINKEPTVLENLSKNTTTWRDLDGNGLLSVDQEIGSYEVVEPELQPTSSTTCKKHPGTIKNPKNGNPENQGIIGGIKKGFSHTGLTSFTPERPPTLKAGPTFSTKSLTLASGASSFNSSSASLTSLTPQTENREEIAIEPPCIITLDIPQIFNNIRLTKIAHSRKKNVISESSSMKNSPVEKFKYLARQLKFSYIREHNVSDSADTAYKNDIENIDVVKNATETHGDNTTTTNNNDDGDDDDDDDDDDKIIESHLLKKYNFPENNTWATLMNEKVNNKKSKRNSSSSREFDEKDVRSSISSISASRQSHDRARKIDKNVEAELQEKIQTLVDLISIATHNASVYLSIDDLTNFKIWILIRDSLLWDLKWMTSSQISSDNASNMDANESSDFEAGENLKTGKEFPEEDGAGTSGAESLVEERPQAFRANSDEPSDAEKKPVSKLKEQLKNTEIIPYAQPNEDSDEVLTKLKELQNQRLESRTKMGETVSDDVIIEEDEHEHQEEEQPHDSPTKSAQFHASPIAKSIPILQKREHRKSFIDTFMLHSPNGYNGDTDIGNEDDNISPRFTYNSVSPRSKVSSLQSYATTTSQLETFKKLSSHTAPIIGSPRHAPSRPDSIGREQLSSSLTKKLAKCKKIIADPPWDTKKLIKQLYNQATETGNVVLTVNILFLFQTIYQITEIDIAKDAIAHFLLLLHRYELFGIAADVLKYCPFEDIMGSEGDQSSIRLFCERCGELITNESSKEKLRAEAQQTGNKKIMDKFGYWYCDSCKKKNTSCVLCERPLKKLTMVILPCGHEGHFQCIQEWFLDENEQECPGGCPGVAFI
The following text describes a protein:
Function:
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin.
Subcellular Localization:
Nucleus.
Sequence:
MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKDKKELLGELTRVLSISTERHRAEVRRAVNDERLTTIAHHMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVMANAVANATAHQNASLPLPAETANKEVVVCYSYTSTTSTPPSASAPSSSSAAVKSPRPASPASNVVVLPSGSTVYVKSVSCSDEDEKPRKRRRTSSSSSSPVLLKEVPKVAVTAPGPKTITLPVSGGPKISNLMQSIANSLPPHMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSNFVPNILSKSHNYAAVSKLVSSAALTASSQKQTMVISAGGSSVAPGPGPVAVTTVVSSTPSVVMSTVAQAGSAAVKVASTRLPSPKALIGSPSQILQIPKAQQAVLQSAAPKALQGSISTAQSTALAAAGPGAKPTIQIKQESGVKIITQQMQPSKILPKPSSAALPSSSSAPIMVVSSNGAIMTTKLVSTPTGSASTYTRPTVSPMGTRVATSPAGATYVKTTSGSIITVVPKALATLGGKIITTSMVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTTLLNAGGEKTLQAIPGAKPAIITASRPITKMIVTQPKSLGAGVQPSTTTKIIPTKIVYGQQGKTQVLIKPKPMAFQTAVVSEQTRQLVSETLQQVNRSAENNTTSTHTSAAAAGLENRDDTHTYTEGSPVPSDSTHDAPPVVHLISSRGQEWAEQEVSVESSPALIYQELTAESQSATSTIKALLELQQTSVKEKSEAKPRQHTIDLSQMAVPIPVSAEQRESPEPSGQSAAESDAHTEFIPIGKVSKAAEVSASSTPGQSASAVSAAPHVVKISTAAVTTQQVEAQVKPQQEQVLVEECELEGDTLDPQTGLFYRSSPQQQLSRVCEAASSSSSSSSSSSRRAEPPLTVKILTHRSSSSAPATAASANTPHTPQLPRLQQAPTTHNRPNTHTQLSQPPPLQAHHPVGSSKTSSGAQVQQPIITQGATVTKITFGAPHVPRAPVSSSSSSEAALKLQAESSSEKPSVPDILKISMMEAEIDPGAEPMLVDSSSDCGPLTKAPAGPSLISSSKQTLAHGPFSRKSKELDIIQVIPQYSIMPDSSQSNVVVEPSGFLEISDYTSQRLDEEQAMEQEVDSSNDEGAAASPSADQSQ
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
MHALVSDIDHYNEYVPWCTASRTLYRSPSVSATHTLTAELQVGFQAFSESYISTVTVTSPTSVRAVASDSAMFKTLINEWKFIPISQLHPHASKSSLSSDERSCIVDFYVAFEFRNAIYAQASKLFLDEVSKSMVTAFADRARVVYGSPARASIKLS
The following text describes a protein:
Function:
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
Subcellular Localization:
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Sequence:
MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQKYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHLEELPVIDELEIQAQESQLFGERIEEDENQ
The following text describes a protein:
Function:
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Subcellular Localization:
Secreted.
Sequence:
MNFTEGCEATGRRPGSAGSRRRRAPRPGPVALLPLLLPLLLPPAAAVPLPAAADSSGEVGLEEEAGARRALLDCEPLARVLRDRAVQLQDEMCKKFTVCENSMEMLVRNNLNLPKVTEEDGCLLAGFDEEKCLTKLSSGLFAFQTYLEFIQETFDSEKQNVESLCYSTKHLAATIRQMVINPDEVVIPDSAAQKSLLANLKSDKDWIEKITMHLILRDFTSFMEKTVRAVRYLKKTRSFSA
The following text describes a protein:
Function:
Modulates the RNA-binding activity of ACO1. May be involved in the cytoplasmic iron-sulfur protein biogenesis. May contribute to oxidative stress resistance and overall cell survival.
Subcellular Localization:
Mitochondrion.
Sequence:
MWRPRLEVFSGLLAQAVPRRPCRAEPHTLQQPGSGPGTAPLCSLPALATGAEAVASWSPGKFNSQFQGFRGQIPKVKKQSVLLLNLRKSGTLGDKNSLDETTYEKLAEETLDSLADFFEDLGDKPFTSKDYDVSLGNYKIWIKYNPCHFEAYNIVGSGVLTIKLGGDLGTYVINKQTPNKQIWLSSPTSGPKRYDWTGKNWVYVHDGVSLHELLEMEFSQTLKTQLDLSSLVYSGKDT
The following text describes a protein:
Function:
Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.
Sequence:
MTKPTSAGQADDALVRLARERFDLPDQVRRLARPPVPSLEPPYGLRVAQLTDAEMLAEWMNRPHLAAAWEYDWPASRWRQHLNAQLEGTYSLPLIGSWHGTDGGYLELYWAAKDLISHYYDADPYDLGLHAAIADLSKVNRGFGPLLLPRIVASVFANEPRCRRIMFDPDHRNTATRRLCEWAGCKFLGEHDTTNRRMALYALEAPTTAA
The following text describes a protein:
Function:
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
Sequence:
MHKRLNKLLVANRGEIAVRIIRAAQALGIPTVAVCSEADRDSLAARLADEVRLIGPARADRSYLDIEAILMAARETGADSIHPGYGFLSENPAFAEAVQAAGLVFVGPEAQTIRRMGDKAEARRTAMAAGVPVVPGSPGELGDLDAALACAEEVGYPLLVKASAGGGGRGIRIAHDADELRREFPIAQREAQAAFGSPAVYLERFIRQARHIEVQILGDGERAVHLFERECSLQRRRQKVFEEAPSAALDGAQRQALCESAVRLAQSLGYRGAGTLEYLFDAHSGEFFFIEMNTRIQVEHPVSEMVTGIDLVQAMLRIAAGEALPWRQEDIRLNGAALEMRINAEDPARNFFPSPGTVERLEWPQGEGVRVDSHLYPGYRVPPYYDSLLAKLIVHGRDRDEAFARARQALERTVLAGMATTLPLHRWLLADARVQAAQFDTATLETWLAERTAAAQEV
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in cleavage axis determination. Binds to receptor tyrosine kinase cam-1. Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18. May act redundantly with other Wnt ligands such as cwn-1 and cwn-2 to control seam cell polarity.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MHINTPVLLAIIYFLVFAPKSADAWWLLSKTDTSSANSGSSPILCKNVPGLTPQQKRMCHENPNIIKYLISGLRSALHTCEYTFQREAWNCTLTLPGVGTSPLQIASRESAYVYAISAAGVSHSLARACSKGLIDDCGCGETPQGSGSVAVSQASSRSSSDFVWAGCSDNVKFGNTFGRKFVDQYDRQHATEPRSQMNLHNNRVGRRLLVNAMNKECKCHGVSGSCVTKTCWKVMPKFDEFASRLHQKYQLAKLVTNNDQKLTVRSSPSAGSSGRSERFARNMDASSKQMRNELIYLDASPNYCAIDVKDRECGENCPNICCGRGWRTTREIVDEPCHCQFVWCCEVKCKTCKKLVERNYCL
The following text describes a protein:
Function:
Involved in ribosomal large subunit assembly.
Subcellular Localization:
Nucleus.
Sequence:
MSRKSTQKKRQPDPEEEEASTASEELVHQHDVDDDDGSDEASGSGSEEEQSESGQSESGEEASDDDDAMDDASDDNNNNNKTTTTTTALLSDGTTEQHTHDLSNLLSFNTHQINSVELYSKGKNKAEWYHGGATIESTIPINESYLLNKAVVGTSQLLGELWKLEMTKTDVGLMAKLPTGGGGDELKLPRALPPPAQKQLTKWEQFALQRGISPKSKRSRKQFDEATGTWKHLTGSLQNKANAGPETWPIIEVKKNDDPNQDPWEKLREEKKSRVNKNVESRMRNAERGGLLEKGSANKMAKGLKKMEKQRELSRENERKKGLVAPVGVPVDMKSHDAKRGKPATQLALKATQVSTASLGKFDKLREGEPERQLQKQASSKNKRKLDPSAIMGGGTNKKFLQTEAQKSQDILSRVINGSKEKERDVRKGKYAKGETAYDYDYDDGLSGGGFRKKKGRAGVGKMRKVTKKRIV
The following text describes a protein:
Function:
Probable transcription factor. Required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and mhc-a at the M-line of muscles, possibly in a signaling role (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized in body wall muscle M-lines, dense bodies and muscle nuclei.
Domain:
The N-terminal part (1-106) mediates the nuclear localization, while the fourth zinc finger is required for the localization to M-lines and dense bodies.
Sequence:
MGDDLFKEARKERDDFEELMNACDLAKMSVKNNEMVHGLETFGVNHGESSSENKPTEIMKVVAPTVEAYVGSSSSTTVTKPSGGAVDGIDQKEVRQDGTSVQKDDNGFIFYKCRFCGLTFNFMNTLRAHERIHDVSQPYVCGKCGESYEFACQLEYHAAQHSEIDGFKCDCGRTFFSYTEMLYHKHTDDPIELIGAPETTTVLVNKKKIIPVTEQDLPQPAFVTEGYEPKHPLRVYSDVRSKPYICEYCSKSYSDSRGLAYHMYSHRGEKQFNPRASRYMMGREGVGYTDSRSYYLFPRTSGYVSPRF
The following text describes a protein:
Function:
Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGFWSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHAAVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYVLTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLENSCQTSCHQNCSRKSSLHFPGDVFAAPEQVGGSPTQGPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHWVLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQGHPAVYRLSFNASLPAPWQAVLPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPSRKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSSSPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGVNRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCRLCKAIAANSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQSGYKIPLPAGASL
The following text describes a protein:
Function:
Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Able to hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan (By similarity).
Subcellular Localization:
Secreted.
Domain:
Organized into two domains: an N-terminal catalytic domain and a C-terminal arabinose-binding domain (ABD).
Sequence:
MLSQPSRERAFVLALGLVVSSSLAAAAPCDIYSSGGTPCVAAHSTTRALYSAYSGPLYQVKRGSDGATTNIAPRSAGGVANAAAQDTFCASMTCLITVIYDQSGRGNHLTQAPPGGFKGPEANGYDNLASAIGAPVTLNGQKAYGVFISPGTGYRNNAASGTAIGDAAEGMYAVLDGTHYNGGCCFDYGNAETSSLDTGNGHMEAIYFGTNTVWGSGSGSGPWIMADLENGLFSGSSPANNAGDPSVSYRFLTAAIKGGPNRWAIRGANAASGSLATYYSGARPNASGYNPMSKEGAIILGIGGDNSNGAQGTFYEGVMTSGYPSDATENAVQADIVAANYAVTSLTSGPALTVGSAISLRATTSCCTTRYLAHTGSTINTQVVSSASATTLKQQATWTVRTGLANSGCFSFESKDTPGSFIRHSNFALVLNGNDGTKQFKEDATFCPQAGLNGQGSSIRSWSFPTRYFRHYSNVLYAASNGGVHTFDAAGSFNDDVSWVISSGFA
The following text describes a protein:
Function:
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Sequence:
MDPKDLQLLANKKHDLLHAAQEARKLSYSPYSKFRVGAALLTKWGEIILGANYENASYGGTVCAERTALAKALIRSDQLDVTEQNSARRIQRGDIIAVAVASDLEGSCSPCGICRQVIREHCSLEARILMVGCNWSRANAAQTIQATIQDQHGKELNEPNVQVVTLDYLLPMSFGPEDLVKPRHS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MEGGRFEEHPALPEQEGLGELPTKLGGGKKESSESTSSGCFDCNICLEFAVDPVVTLCGHLYCWPCIYKWLEVESAIPQQCPVCKATVSETTLVPLYGRGNTCSNKESYKNGTMDIPRRPAIQHRGQTLAASLIQPAFPPSTTSHRRRHHHQNIDGGDTMPLDGVSQLMGSAAVAVLPWVFGEHISTGLQYSNRYFLVGDEISPRQRRHEMLARRSLHHVFVFFFSFMVLCLVFF
The following text describes a protein:
Function:
May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MRRLFLELYYKLIFSSTPITSFSLFLLYIVVTPLMLGFEKDFLCHFHLGLIWISLLFSFLSAPFFRNEKEDGTLELYYLSTYCLPKILLLQLVGHWVIQISCVFCGFPMLQLLYQFGRSGMDWLNILLGSLVLTLLCGIHSCLALGITSSSGWNSLQNLTTLPTLLPLTVFCTSIETEWFHVLLLIGYFFLFVSLFPILVSISLQD
The following text describes a protein:
Function:
May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MQPPWGLALPLLLPWVTGGVGTSPWDYGLSALAHQPGVCQYGTKMACCYGWKRNNKGVCEAMCEPRCKFGECVGPNKCRCFPGYTGKTCTQDVNECGVKPRPCQHRCVNTHGSYKCFCLSGHMLLPDATCSNSRTCARLNCQYGCEDTEEGPRCVCPSSGLRLGPNGRVCLDIDECASSKAVCPSNRRCVNTFGSYYCKCHIGFELKYIGRRYDCVDINECALNTHPCSPHANCLNTRGSFKCKCKQGYRGNGLQCSVIPEHSVKEILTAPGTIKDRIKKLLAHKRTMKKKVKLKMVTPRPASTRVPKVNLPYSSEEGVSRGRNYDGEQKKKEEGKRERLEEEKGEKTLRNEVEQERTLRGDVFSPKVNEAEDLDLVYVQRKELNSKLKHKDLNISVDCSFDLGVCDWKQDREDDFDWHPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKNEDGRWRTGKIQLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSVEG