lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSSQGEQKDLAAEFMSKVKITDYPDLGNRFEPKTSEPITRPLDSLDEVLLWQPDDQFNVANSPLATPTTPAEPRPMTLVCHDMKGGYIDDRFVQGVPISSAYRFYHWQYIDIFIYFSHHFVTIPPPCWTDAAHKNGTLMLGTVITEWQDGKKRCAEMYGSEAACKRFADKLVEIAKYYNFEGWLINIENPIPPEHMPQLLFFVQYLTKQMHQHIEGSKVIWYDSVIADGSLRWQDMLNDNNRIFFDASDAIFLNYTWNENKLASSVQNAGPRKHDVYVGVDIFGRNCFGGGGWNTNKAMEVIKRQGLSTAIFAPGWVMEKLGEADFVANQDKFWSLLDSYLYTHGVSSLPFVTNFCRGYGEFGFKCGNEVMKKAWCNLSSQQIVPTYGKEQFSDVEGASKKTVMQYVVSDAFNGGGCVEIHGGLAASQVTRCKLFATGISGSHPLLVSYTAKHGDNCKMCLYLSTPNKEILLWNTADDMKAGEQPMSTYGLRLSALVDHSTVPDSLKSSDPTIFSPLVGTCHKILQDASFGIDSSVVPTQGWVTRNYLVPESVLTAGAKITEIGLLCFSAAPVESYSVKIGEIKVVDPGSLRDQTQQVTDLSCQDVTWHPPIANVVDPHTVVSLCATLTWSYPAGLGDHFDIYCSGIERDPNQSRAVSKSDKLFVGRAHSHSFRVCHLLIPKIENEGQEDCIEFCVQPTTRAGFSAPLLDVSSCKVVYSK
The following text describes a protein:
Function:
Could be involved in signal transduction.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESPHTSEFKGAARVSPISESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVKTPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD
The following text describes a protein:
Function:
May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKLTTILFQYKIFPVLMFLVSTGLGIIVITQNILIADFLAKIIRHQFQGLWIVLFILLGVLLLRATVQFLNQWLGDTLAFKVKHMLRQRVIYKNNGHPIGEQMTILTENIDGLAPFYKSYLPQVFKSMMVPLIIIIAMFFIHFNTALIMLITAPFIPLFYIIFGLKTRDESKDQMTYLNQFSQRFLNIAKGLVTLKLFNRTEQTEKHIYDDSTQFRTLTMRILRSAFLSGLMLEFISMLGIGLVALEATLSLVVFHNIDFKTAAIAIILAPEFYNAIKDLGQAFHTGKQSEGASDVVFEFLEQPNYNNEFLLKYEENQKPFIQLTDISFRYDDSDRLVLNDLNLEIFKGDQIALVGPSGAGKSTLTHLIAGVYQPTIGTISTNQRDLNIGILSQQPYIFSASIKENITMFKDIENNTIEEVLDEVGLLDKVQSFTKGINTIIGEGGEMLSGGQMRRIELCRLLVMKPDLVIFDEPATGLDIQTEHMIQNVLFQHFKDTTMIVIAHRDNTIRHLQRRLYIENGRLIADDRNISVNITENGDDL
The following text describes a protein:
Function:
Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Sequence:
MLADAARSGRLPVEIAVLVYNNPGAYVADRARAAGIAAVLLDHRKFVSREVLDEEIVATLEAHGVELVVMAGWMRKVTEVLIGRFADRILNIHPSLLPAFRGAKAIEQALDYGVKVAGCTVHIVRLEVDAGPIILQAAEAVREDDTPETLAVRIHAHEYRILPEAVRLFAEGRVRVEGNRARIVIDEVEPTGFEEQL
The following text describes a protein:
Function:
Transcription factor. May be involved in the differentiation of stomatal guard cells.
Subcellular Localization:
Nucleus.
Sequence:
MELSTQMNVFEELLVPTKQETTDNNINNLSFNGGFDHHHHQFFPNGYNIDYLCFNNEEEDENTLLYPSSFMDLISQPPPLLLHQPPPLQPLSPPLSSSATAGATFDYPFLEALQEIIDSSSSSPPLILQNGQEENFNNPMSYPSPLMESDQSKSFSVGYCGGETNKKKSKKLEGQPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDAIDYMKELLDKINKLQDEEQELGNSNNSHHSKLFGDLKDLNANEPLVRNSPKFEIDRRDEDTRVDICCSPKPGLLLSTVNTLETLGLEIEQCVISCFSDFSLQASCSEGAEQRDFITSEDIKQALFRNAGYGGSCL
The following text describes a protein:
Function:
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway. Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion. Note=Colocalizes with sites of active transcription. Predominantly nuclear. Translocated from nucleus to mitochondria to mediate antiviral immunity. Localizes to sites of DNA damage.
Sequence:
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESEDNKFSDDSDDDFVQPRKKRLKSIEERQLLK
The following text describes a protein:
Function:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 1 is essential for cell cycle progression. It may associate with components of the DNA replication machinery and serve to enhance the efficiency of DNA replication.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSNSDIRSFFGGGNAQKKPKVSPTPTSPKPKRSLKKKRIVLSDDEDGTIENSKVPASKSKVQKRNESEDISHSLPSIVHEDDKLVGSDGVSTTPDEYFEQQSTRSRSKPRIISNKETTTSKDVVHPVKTENFANDLDTTSDSKPVVHQTRATRKPAQPKAEKSTTSKSKSHTTTATTHTSRSSKSKGLPRFSDEVSQALKNVPLIDVDSMGVMAPGTFYERAATTQTPGSKPVPEGNSDCLSGISFVITGILETLTRQEATDLIKQYGGKVTGAPSVRTDFILLGENAGPRKVETIKQHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKKEQEEKKILETVARMDDSNKKESQPSQIWTSKYAPTSLKDICGNKGVVQKLQKWLQDYHKNRKSNFNKPGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASDTRSKRLLDEQLFGVTDSQSLAGYFGTKANPVDMAKSRLVLIMDEIDGMSSGDRGGVGQLNMIIKKSMIPIICICNDRAHPKLRPLDRTTFDLRFRRPDANSMRSRIMSIAYREGLKLSPQAVDQLVQGTQSDMRQIINLLSTYKLSCSEMTPQNSQAVIKNSEKHIVMKPWDICSRYLHGGMFHPSSKSTINDKLELYFNDHEFSYLMVQENYLNTTPDRIRQEPPKMSHLKHLELISSAANSFSDSDLVDSMIHGPQQHWSLMPTHALMSCVRPASFVAGSGSRQIRFTNWLGNNSKTNKLYRMLREIQVHMRLKVSANKLDLRQHYIPILYESLPVKLSTGHSDVVPEIIELMDEYYLNREDFDSITELVLPADAGEKLMKTIPTAAKSAFTRKYNSSSHPIAFFGSSDVLPMKGSAQREVPDVEDAIEAEDEMLEEASDSEAANEEDIDLSKDKFISVPKKPKKRTKAKAEASSSSSTSRRSRKKTA
The following text describes a protein:
Function:
Acts with RNA polymerase to initiate transcription from late gene promoters.
Sequence:
MNLRLCSGCRHNGIVSEQGYEYCIFCESVFQKCTKVQKKSNFHVSNKLIHLRNVLRRLLSHQCSGEIISELLDIMEKNQISTDDVDANFVSSFLKANERINKKDYKLVFEIINQVKDEKLNLSTEKINEVVEIFKHLVFFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV
The following text describes a protein:
Function:
Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body.
Miscellaneous:
MISCELLANEOUS: Experimentally shown to bind zinc.
Subcellular Localization:
Nucleus.
Sequence:
MVSEENWNSDTMSDSDMIDSKNDVCGGASSSSGSSISPRTPPNCARCRNHGLKITLKGHKRYCKFRYCTCEKCRLTADRQRVMALQTALRRAQAQDEQRALHMHEVPPANPAATTLLSHHHHVAAPAHVHAHHVHAHHAHGGHHSHHGHVLHHQQAAAAAAAAPSAPASHLGGSSTAASSIHGHAHAHHVHMAAAAAASVAQHQHQSHPHSHHHHHQNHHQHPHQQPATQTALRSPPHSDHGGSVGPATSSSGGGAPSSSNAAAATSSNGSSGGGGGGGGGSSGGGAGGGRSSGTSVITSADHHMTTVPTPAQSLEGSCDSSSPSPSSTSGAAILPISVSVNRKNGANVPLGQDVFLDYCQKLLEKFRYPWELMPLMYVILKDADANIEEASRRIEEARVEINRTVAQIYYNYYTPMALVNGAPMYLTYPSIEQGRYGAHFTHLPLTQICPPTPEPLALSRSPSSPSGPSAVHNQKPSRPGSSNGTVHSAASPTMVTTMATTSSTPTLSRRQRSRSATPTTPPPPPPAHSSSNGAYHHGHHLVSSTAAT
The following text describes a protein:
Function:
Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function (By similarity). Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (By similarity). Plays a role in the rate-limiting-step for the maximum level of testosterone production by the testis but does not affect basal testosterone production (By similarity).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MEQFLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQVISEEIERTTGSRVKVVQADFTREDIYDHIEEQLKGLEIGVLVNNVGMLPNLLPSHFLSTSGESQSVIHCNITSVVKMTQLVLKHMESRRRGLILNISSGVGVRPWPLYSLYSASKAFVCTFSKALNVEYRDKGIIIQVLTPYSVSTPMTKYLNTSRVTKTADEFVKESLKYVTIGAETCGCLAHEILAIILNLIPSRIFYSSTTQRFLLKQFSDYLKSNISNR
The following text describes a protein:
Function:
Has a non-vital function.
Subcellular Localization:
Cytoplasm.
Sequence:
MVHPQLKRSIESLSFSGYKLTRRNLYNAPALKVMGRSVNNSSSNNNDQQQYNLESAKQNTQIVVIGAGLAGLSAAQHLLRHGFRSTIVLEATDRYGGRVNSKRFGDTYCELGAKWVNMNIDGAHNTIYELLRNAEGLRKQLKQRECANYVHTQGREVPPNMVELIDMQFRQLCRGFKVSEKVKSGGDLHVLDNVMAYFKTESEKLVGHSYPDPEKRALAREIFQSLFKEFSSILGCCLEYVNIEHITSCPVQQELRPLYVPTGLDNVLDTLTQHISKEQLQTGKPVGSIQWQTLSDFGAPTSPLPQERKCVACLDGTLYSADHIICTLPLGVLKNFSAILFKPALPLEKLQAIRNLGYGNPVKIYLAYKRPISRWLKSNLRPLGAQLGKDEPAITVNGRQERLWTQQVVEISQLPSSQHVLEIRVGGGYYDEIEKLPDVTLLEQITALLRQCLRNRLVPYPQALLRSNWSTSACYLGGRPYFSTTSSARDVQRLAEPLGDIAPTLLFAGDATALKGFGTIDGARTSGIREAQRIIDYYYLKQYM
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPNGMMPMNGEQTTPIIPQNRNISLSLVIHRLVEQSYNSLLGLTEGLPKANDLERKKAIVDYLDGTREKFLRLMVLIKWSEHVPTLTKANNIIDILNLEDSYLREAADLLINTQFSLVNARAPIYDVPTAIDVLTTGTYQRMPTNIKRVIPPPPLKPTQIESALERLNDIIKYKLFISDVPKEFQPITVSDGKAHIFVDDEYEAYLTIDGGSEKSNWVILSLNLFVYSKRNLNGEGPIKVAYDNKMKYVLDRVQNRIISSAQPLFELHNIVHYLCISSQMDILASQVENLKKTILKNNIRCVFGKDQSITVFYWLPEDFNLVGVTQHTLGNLMPNKHTNFKIYIDEHQKIKISHYPPITHPKNENYFKIASLNLETILLQAIELNAYDKVYLLNSLLLDNRITANTTSSSSSSSSNNNNTASPIINRNNNNGKPNLLSTKQSNNPLSRSFHLNDIKLIMSSRFSDENQNDSNGNNDHLPTVLRVMLYGSKFLDITVNFQNGKFSLIKSSNYIEFTNHLEQRLNKDPNEIESIVNVFKLKSLLTCFEEASLFLGLECFNKIPLQMNSSNNSESNQLANELFSDSNFICVSISLAKENNPYYLVISIKATCFTPSFHLLFCKMLPKSTIMTLDSIIKLESDQLNKLLKECPIGSISSSNNTNSNGNGPFQSYISTLLEKIVEASNQKINLLSIQSFLKKENINYYQPSQQDIENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGNNGYKNNGITTTTSIVFLFNEQQIQKISPFLSNHISHQTPITISFKNGFYTLSFTQQRPFEYKKYGSGSNININSFGENNSNENYIYRKGNWIFKYQQTSDWFNSFCNDLMTISKITNISSQLLKQMETLEIYKQLITHLTIKPMSIEFVCFVGSNQTRTNVIMFVEKKTAEIKLSFQPYSNPLLVYLEKDINQSPTNDITNSLRAIINSNDISVYINSLISPLELSFYLPLEILVIPRSICQIRLLYKNLYGIDIKLISHEYCAISDSFYSLNSSKQVRLTSINQLHSFMEQRVSLQALDNPTGHRTSWLLPIKQFQKTISRIFIYLNSLNTLKFAQNLMKPNFQPLVPSNPSSQKFSNDYFIVSFSIRDYTSFDIDVTNKNLENSVPSNEELALFCQYFKKKVQQLNYRSQTIGSCIQMLTLPPKILWEFIRVLLEITGPKFDGYTIEISLNTSSIHSKNKESFFHIPDENQVYFILRYLNSSRTDIIPPDQFTDIPIIYNYNEKSIRYWNKLDSNSTSSSSSSTLPKKSLSIVEEVKQKFVEEVAKLIPDALNASSGKSSPISIFFKSFLPKIKPIFSNPTASTLLLIQQQQQQQQQQQQQQQQQQQQQQIENNNFASASSSIR
The following text describes a protein:
Function:
Involved in the degradation of asparagine-linked glycoproteins. May hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond.
Subcellular Localization:
Lysosome.
Sequence:
MKVIFLLILLILLKIVKSYECNCILKEYCKPLEVGERIEFIGFSFNSTGNYLNYDYYSVTTIAISYQSNYDIPEELVCKSHENRVRLVWSAIISNNQISNETYRNQFIDSIVETIQKENMDGVIYELDNPNDLTIENSDYFTEIIKKTYQKLKLINWNYQISAKFPFSPNIDFSYNYPEISYYSDYLVIMDYNIGSRVSNDGNYCLAGSNSPNPLIEQGVHNFTSMGIPGERLVLTYPWFGLDFICFNGNLSSVDCLVTKSENVSCNDINSISNQISYGEILKILNDDNIINGGINWNSQSKSVFFNYYDKQGILHQIHFDNPKSLFIKVFLTKRLKAKGIAAQSMDNLDFNDLVNSYNMFDTMAYFFM
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MIIPSNNKKILDLTIEILSLLTGEDYILVKKELRYGEGYTESYISRGFCQPPGSIEETNSFPQLRENDKKILEHTNKIIYLLTGEIPVRCEDVAIYLSVEEWEYLDGHRELYMEDKVTSLLGRKRFCFPYPAGECKNMNTTETGCLSLYPQHGTEEEMGTEQDIKAEQADLVHTAEEIQTDDVVIKKEAPSEGYPVTIAAPACEEYKREEISSPDQNQISTNRLKRAALDKEVHSLLEAHFMDSSSDQREMECLSDFIEIPKSKGSTCTDCGRHLTVESDYICHQKTHNAEMFLCSECHECFGSLAELVTHQTLYKEQCDKNVLSRAKYPTQQEKKLLSCNECGQGFTQIAHLVTHQKTHGGVKPFPFSKCGKSFAKHSNFVMHQKIHSGERPFVCTECGKCFTQSSKLLTHQGTHTEEKPFTCSECGKSFSQISHLLTHERIHTGEKPFSCLECGKLFTRKSTLLKHQRIHTGAFSCSYCGKCFSQNSNLVAHQRIHTREKPFGCGSCDKCFTDKSALIKHERIHTGERPFICPRCGKGFTQISHLITHKRSHTGEKPFVCPDCGRCFAGKPALVKHQRIHAKETPLMY
The following text describes a protein:
Function:
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Sequence:
MDLFNYFRRETSEVNIGAVPLGGPNPIRIQSMTNTSTMDTEACVEQAKRIVDAGGEYVRLTTQGVKEAENLMNINIGLRSQGYMVPLVADVHFNPKVADVAAQYAEKVRINPGNYVDAARTFKKLEYTDEEYAQEIQKIHDRFVPFLNICKENHTAIRIGVNHGSLSDRIMSRYGDTPEGMVESCMEFLRICVAEHFTDVVISIKASNTVVMVKTVRLLVAVMEQEGMSFPLHLGVTEAGDGEDGRIKSALGIGALLCDGLGDTIRVSLSEAPEAEIPVARKLVDYVLLRQDHPYIPGMEAPEFNYLSPSRRKTRAVRNIGGEHLPVVIADRMDGKTEVNPQFTPDYIYAGRTLPEQREEGVEYILDADVWEGEAGTWPAFNHAQLPLMGECSAELKFLFMPYMAQTDEVIACLKVHPEVVVISQSNHPNRLGEHRALVHQLMTEGLENPVVFFQHYAEDEAEDLQIKSAVDMGALIFDGLCDGIFLFNQGSLSHAVVDATAFGILQAGRTRTSKTEYISCPGCGRTLYDLEKTIARIKAATSHLKGLKIGIMGCIVNGPGEMADADYGYVGAGRGKISLYKGKVCVEKNIPEEEAVERLLEFIRNDRKELEL
The following text describes a protein:
Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP. Can use 2',3'-cAMP, 2',3'-cGMP, 3',5'-cAMP, 3',5'-cGMP and 3',5'-cUMP. Hydrolysis of 2',3'-cAMP produces a mixture of 3'-AMP (major product) and 2'-AMP (minor product). In vitro, is 150-fold more active in hydrolyzing 2',3'-cAMP than 3',5'-cAMP. Can also hydrolyze the model substrates p-nitrophenyl phosphate (pNPP), bis-(p-nitrophenyl phosphate) (bis(pNPP)) and p-nitrophenyl phenylphosphonate (pNPPP). Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. May play a role in pathogenicity, not only by hydrolyzing cAMP, but also by altering properties of the cell wall; Overexpression elicits a transcriptional response that is independent of the phosphodiesterase activity. It does not alter the levels of cAMP-CRP regulated genes, even though cAMP levels are reduced in cells.
Subcellular Localization:
Cytoplasm. Cell membrane. Secreted, cell wall. Cell envelope. Note=The C-terminal extension (CTE) is necessary for the localization to the cell wall and cell envelope. Phosphorylation at Thr-309 promotes cell wall localization.
Domain:
The C-terminal extension (CTE) is used to better adjust the substrates into the active sites and mediates in vivo subcellular localization of the protein. It also modulates expression levels of Rv0805 in mycobacteria.
Sequence:
MHRLRAAEHPRPDYVLLHISDTHLIGGDRRLYGAVDADDRLGELLEQLNQSGLRPDAIVFTGDLADKGEPAAYRKLRGLVEPFAAQLGAELVWVMGNHDDRAELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGIPVSVASATCYTQDLTVAAGGTRGRDGAQGCNLVHVYPDTVVHSVIPLGGGETVGTFVSPGQARRKIAESGIFIEPSRRDSLFKHPPMVLTSSAPRSPVD
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNPLIDAASVIAAGLAIGLPSIGPGVGQGTIVGQAVEGIARQREAEGKIRGTLFLSLAFMEALTIYGLVVALALLFANPFV
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MINPIASESEAINSATYVDNYIDSVENLPDDVQRQLSRIRDIDVQYRGLIRDVDHYYDLYLSLQNSADAGRRSRSISRMHQSLIQAQELGDEKMQIVNHMQEIIDGKLRQLDTDQQNLDLKEDRDRYALLDDGTPSKLQRLQSPMREQGNQAGTGNGGLNGNGLLSAKDLYALGGYAGGVVPGSNAMTSGNGGGSTPNSERSSHVSNGGNSGSNGNASGGGGGELQRTGSKRSRRRNESVVNNGSSLEMGGNESNSANEASGSGGGSGERKSSLGGASGAGQGRKASLQSASGSLASGSAATSSGAAGGGGASGAGVVGGNNSGKKKKRKVRGSGASNANASTREETPPPETIDPDEPTYCVCNQISFGEMILCDNDLCPIEWFHFSCVSLVLKPKGKWFCPNCRGERPNVMKPKAQFLKELERYNKEKEEKT
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MRSLYTIRMAVGIIGNGASLLLYTVPILTFWRVIKKKSTEEFSCVPYIVALMNCLLYTWYGLPIVSKGWENFPVVTINGLGILLELSFISIYFCFASSQAKKKVVLKMVGVVTVFLCVGMISSFVLKTHHLRKFFVGCIGLVASIAMYASPLVAMKQVIKTKSVEFMPFYLSFFSFSASSLWLAYGLLSHDLFLASPNLVGSPLGLLQLVLYCIYRNKEHEQGVLKKEKGGVIMEIQPNWDLEKNNNENHIPHQNNSKI
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
SVLVVACVVAACVTLTKHDSDTSSNGVATSTKSVESMCQPTPYKQTCEKTLSAAKNVSDPKDYIKVAFEATVADIKNAIKNTEPVKKAASDPYTKDALLACEEVFDLAVEELRGSIARIENFDFSKMKDIVDDLKSWLSAVVAYEETCLDGFTKSEYSATRDEMMKLMSTTRELSSNALSMVNNFGEMITQNTGLTRKLLSNSDSFVEASNRKLLQISASKPNAVVSTSGGGQYKTIQEALQAVPRSSPTPFVILIKAGTYKEHIEIEKNMLNVVLIGEGPTKTIITGDQAVVPNRISTWHTATLGVCGDGFVMKDMGIENTAGPTKEQAVALRINADKAVLYNCNIDGYQDTLYAHSGRQFYRDCTITGTIDFLFGDASAVFQNCKLIVRKPGPNQACMITAQGRMRKDSLGGFVIQNCDIKADQALTSANPPVKVYLGRPWKEFSKTIIMQSNIDGFVDPSGWSPWNTTDFGIHTCFYAEYQNRGPGAALDKRVSTWRGYQKDISGDVINSFTAGKFINTQQPWLPMFDIPYEAGMMKIKDVVEDLKTWLSTVIAYEETCSDGFIKSEQSATHNKMMKILNTKELIFGETITKTTGLTRKLLSNSDWFVEASSHKLLQISPSKPNAVVSASGDGQYKTISGELNAVLMNYTTPFIILIKAGTYKEHIEIEKTGKCCNGGGVVKWHTTSLGVSGERFVIRDIGIENRAGPVKEQVVALRINDDKAIVYNYKIDGFQYILYAHSYR
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MRRTTLGPVSSAQLNTRTSVLRHPSTRVSVPNKSSASERQSIGISVVRRSSTYGSRSSVSGRGGTRVLDPRPTSDKSYLNSCVKTLVEFLSDHMYDQTLPHGLLRRGPSKKEFCNMILFLFKQVDPTFEFGVKFEEDVVLQFRNLRYPIPISKTSLAAVGTPHTWPTLLLSISWLIELLTYDEAIQLANESEQSEENDEENGDKLFFKYLDASYHAFLAGEDDKFAMLERQEREKLTFKDEYCLLTLGWFFVTVTRNETVKQETSELEQQREELKKRIENAKKEKNALSLLKANKLDCESDLKKFKDYVAKHEKRKAKLEKKVGSLAEEQQSIEDELNVRQQEIQRLLTRIENQELSAYDIEQIAQERARLTDQLHQVIDRQNALQQQTKKDENRGVEKRDILKIVPRTAKNALNFDYTLELDQELEELDAVLKLNHHLKTSVRKAALELKQNRIARANAGLDQALVLDEELQQWEDRLNIETQSERRWESEVKKYSEQMRKEREKRADNLNRKSAATEEVEMRITEISNEDNLPEEETTSRQHLMDVRKASVEMTEAYQALLDKNRHAVTNVLLACTNHKAAVDRAIASLEVEVSKVEL
The following text describes a protein:
Function:
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
Sequence:
MPRVKRGFKARRRRNKVLKLAKGFRGARSKLFRSATEAVDRALNYAFRDRKVKKRDFRALWITRINAASRLNGLSYSKLIHGLKQAQVEIDRKVLADLAVSDPKGFSEIATLAKAQF
The following text describes a protein:
Function:
Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins).
Subcellular Localization:
Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side. Secreted.
Sequence:
MAPPALLAAALWLLVPTVALPLDRPGPKKGNEPPPEAPSGKLSRELDFVSHHIRTKLDELKRQEVSRLRMLLKAKMDAMQEQEVQVDHLSLLKQFDHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHAEFKRYEMLKEHERRQYLDSLDGERRREEERRLQEQQKRHRQHPRVNVPGSRAQLQEVWEETDGLDPAEFNPKTFFRLHDTNGDGVLDEQELEALFTKELEKVYDPKNEDDDMREMEEERLRMREHVMKNVDTNHDRLVTLDEFLSSTQRKEFAEAGGWETVEEQPVYTEEELVRFEAELAAREAELSERAAQLGREHEALERSQGQLEAKKQELKQAVLQMEQRKQQPPAPPAPGPEGQLLFQPQAGRRGGTSGPLKGARQGGRGSRGWGWGAWIPPLPISQPVTFIERLLGAEHGSKHSGEFKVPVGRYGPSVVTGAGAPGPRDALPASATPDQKPTQPPGDHPPQPDQLQ
The following text describes a protein:
Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATLDSDQVTKAAKALVNFHQERGTKKKGKKDLLEDEAAMPVFMQFSVKRIPKEKNQKYLIKLPHSIEKPTEVCLFTRDRKNLEPELPTTEMYYMDLLKKHGVTCVTEVISYKKLSKEYKQFESKLRLLKSFDLFLSDRGVTRMLPSHLGKHFYKAKKFPIDVNLEKKDLKPEFQRVLGSTRCTVTGHGSCSSVMVGTTSMTAEQVTENVEAVAKELGDKIEFGWPNIKSVSIKSQKSPALPVYVNVEPLQLPSETIAAWREERLQNQEERQSAKKRKNRKRKRKPKQADKSDEAKAGDKKQTPEQPGESKKQKKKKSVEGKENAEGKEGPAQGKAQGPKQESAVQQKKQAAGQKGAQKSVSEPMKTQNGQDTKDKKAKKAGKDQKQAAETAKAVGVTTKQEPQKKAKLDKVEKQEEKKEEDAEDVVEEKDEDEDEEMYSDESELEFESDDEDDEEEDSFIDDEAEEGEETDDSDAWELMEEDVESGEEEEEADEDDEPTPPKKRKVVEPVEPAASPKKNIKATPKSTQKAAAAAQKKNTPKSTPSNKPQTTPGTAPSPKQGTAGKPKTPKATPKQKATPKAAAKIPQKATPKASSTPMPTTPMTGAWQVTPGQKAGGKTPVGKKAAGKGSKPATPMSAKGKRKQN
The following text describes a protein:
Function:
May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQFSSVVHLYRDGKDQPFMQMPQYQGRTKLVKDSIAEGRISLRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSVPLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSISCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIFFSKFQWKIQAELDWRRKHGQAELRDARKHAVEVTLDPETAHPKLCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQSFQAGKHYWEVDGGHNKRWRVGVCRDDVDRRKEYVTLSPDHGYWVLRLNGEHLYFTLNPRFISVFPRTPPTKIGVFLDYECGTISFFNINDQSLIYTLTCRFEGLLRPYIEYPSYNEQNGTPIVICPVTQESEKEASWQRASAIPETSNSESSSQATTPFLPRGEM
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Sequence:
MFGFCGSQTLFTACELGIFDLLHASNTPLSANAIAKDLSTDVDATGRLLDALVCLELLEKTPASPPVYMNTPTTDRFLLQSSPNSVKPCMQFGGTVLYRLFSNLTSAVRDGNNQWGRTFNGSTAGDFFKSAYATREGVIRVLEGMRGTSRPVAPLVVTAFDLSSFATMCDVGGGTGDLAYAASNAYPDMAITVLDLPPVVQCSPHFRPSMEECPRQENVTFVPGDFFRDELPPADLYVLTHTIHDWGEDKIEMLLSKVFRSLQPGGGLLIGEILLSDRKTGPFQGVMASLTMLVLCDKGARERSEQEYRDILERHGFIDIQAKRTGTAFMDAILCRKP