lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MEMDNFPPYLLTKEEGVSLKRRFEMKSGINFVRSSNYRAPNEKEMNLHFVDKNKVVCNNEYPYSIINTDTYECMYGRERHAARKKRLLEEPRSPSKRAYNGDHASRKKGCPAKLILKEVVMYTDFKLDDAMSDWKKKLIGRDLRSALNTKANLNKEVRIYVKYPLDEDHLSGHEVRQQAYQKPASTCSSSSNHSILSALEVPGALELGEEVEVEYHETTLTPADQTEKLVNVLNSAPESELKMVKYINSKMAAGIIAHREEKGQISRLEELLVIPGVGRRILDKLLTSFANGKQEKTRTRIDPQSTSHTELSNERLSSLKDVVAIDVGLKHIAWLHMDKDRWVHNWHCKMIEGISPGKWDPINYLRFISDTVEEMPRPDLYVLEHKSFTSLNKGTFQTMLFVRCLESMLYTRLNSDIIETGQAKAISLPQNVVGRHFDLLVGTQRKSGQALARALLEEGVGMRNAWYPVRIGYENMAIFCNVNKYKREHLANCLLRATAFYDIHIDKKPGFKLT
The following text describes a protein:
Function:
Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine. The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site.
Sequence:
MTSTDNEPVQVNQYPYLFVGSVAAALNEDSLREHNITHIINWSSSAKCNLFSGIEYLCITGVRSKSQVKVSHLDKAVEFIETARKGGGKAMSHCWYGRNRSVSLLVAYLMKYADMSAREANDLIKQTRPHAEPYWDQLQQYAEFLSSN
The following text describes a protein:
Function:
Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MATALMAVVLRAAAVAPRLRGRGGTGGARRLSCGARRRAARGTSPGRRLSTAWSQPQPPPEEYAGADDVSQSPVAEEPSWVPSPTPPVPHESPEPPSGRSLVQRDIQAFLNQCGASPGEARHWLTQFQTCHHSADKPFAVIEVDEEVLKCQQGVSSLAFALAFLQRMDMKPLVVLGLPAPTAPSGCLSFWEAKAQLAKSCKVLVDALRHNAAAAVPFFGGGSVLRAAEPAPHASYGGIVSVETDLLQWCLESGSIPILCPIGETAARRSVLLDSLEVTASLAKALRPTKIIFLNNTGGLRDSSHKVLSNVNLPADLDLVCNAEWVSTKERQQMRLIVDVLSRLPHHSSAVITAASTLLTELFSNKGSGTLFKNAERMLRVRSLDKLDQGRLVDLVNASFGKKLRDDYLASLRPRLHSIYVSEGYNAAAILTMEPVLGGTPYLDKFVVSSSRQGQGSGQMLWECLRRDLQTLFWRSRVTNPINPWYFKHSDGSFSNKQWIFFWFGLADIRDSYELVNHAKGLPDSFHKPASDPGS
The following text describes a protein:
Function:
Plays an important role in the biosynthesis of the phospholipid phosphatidylcholine. Catalyzes the formation of CDP-choline.
Sequence:
MARVSNARKRQGAKPAAAATPSSAADPAHNNTTSSSAKQAAGSGDRPVRVYADGIFDLFHFGHARALEQAKKLFPNTYLLVGCCNDELTKRYKGKTVMTQEERYESLRHCKWVDEVIPDAPWVLTQEFIDIHQIDYVAHDALPYADTSGAANDVYDFVKKIGKFKETKRTDGVSTSDLIMRILKDYNQYVMRNLARGYSRKDLGVSYVKEKQLQVNMKINKLRETVKAHQEKLQTVAKTAGLNHDEWLANADRWVAGFLEKFEQHCHNMVICFSKNVVLPKLAKWNFKLVRLDRRQVNTCNNWGKFAGFQLKQISF
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in detoxification of isoniazid.
Miscellaneous:
MISCELLANEOUS: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide can subsequently be reduced through a mixed disulfide with the C-terminal cysteine of AhpD, resolved by its second cysteine or by thioredoxin (TrxC).
Subcellular Localization:
Cytoplasm.
Sequence:
MPLLTIGDQFPAYQLTALIGGDLSKVDAKQPGDYFTTITSDEHPGKWRVVFFWPKDFTFVCPTEIAAFSKLNDEFEDRDAQILGVSIDSEFAHFQWRAQHNDLKTLPFPMLSDIKRELSQAAGVLNADGVADRVTFIVDPNNEIQFVSATAGSVGRNVDEVLRVLDALQSDELCACNWRKGDPTLDAGELLKASA
The following text describes a protein:
Function:
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
Subcellular Localization:
Secreted.
Sequence:
MQPLWLCWALWVLPLASPGAALTGEQLLGSLLRQLQLKEVPTLDRADMEELVIPTHVRAQYVALLQRSHGDRSRGKRFSQSFREVAGRFLALEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLGDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAENWVLEPPGFLAYECVGTCRQPPEALAFKWPFLGPRQCIASETDSLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP
The following text describes a protein:
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Subcellular Localization:
Nucleus.
Sequence:
MPKRKAEGDTKGDKAKTKDEPQRRSARLSAKPAPPKPEPKPKKAAPKKGEKVAKGKKGKADASKDGNNPAENGDAKTDQAQKAEGAGDAK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSDEEKGDANNEYLAQIYQRKECILWGSIYATNLIDLENRLAGICDPGCTPFHEHEMSFSLKTTQTPDVTLRLRRKFHTETTSSNQWRFRYVGRPEPDPNCPVVVRKVIDSVAHSQNMMEFVKTLGLRLDYEYMAKGKVWTCGAIKIVVSSLKRTKQPGKYEVENLEKMSDSYLIELSVTINDSVDYHPIAKQLKAFSSQLSPLVELQKVEYWVK
The following text describes a protein:
Function:
The small GTPases Rab are key regulators in vesicle trafficking.
Subcellular Localization:
Membrane; Lipid-anchor.
Sequence:
MRLKIIVVGDPSSGKTSSIHQFCDGIFDNNYQPTIGVEFSSKFISIDGKSVELRLWDIAGQDHYAGMSRVYYNGALGAIVMCDVTNKNSIEGAMKWKANIDDRVLFNNEKIPVLLVGNKTDLIQDEAQLKAIQYQLGEISASNGFSGYILTSARTSHNLEESMVRIAKFIITKYGALLDNTQPEEAAPNIDLMQFPETKKLDGCCH
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MTNTVDELKRVRRLFFALTLPDAMQQEIVQWRAGHFSPEAGRPVAAANLHLTLAFLGEVSATKSQVLQQQAGRIQQAGFSVTLDDIGHWPGSGVIWLGCKNPPRGLLQLAQLLRSQAARSGCYQTPLPFHPHVTLLRNATRPVALPAKSGNETFQADHFSLYESVFARGRTRYNIVQSWPLAGSERKPDAC
The following text describes a protein:
Function:
Involved in the control of mitochondrial and peroxisomal division and morphology. In association with PEX11C, PEX11D, PEX11E and FIS1B, is involved in cell cycle-associated constitutive self-replication of preexisting peroxisomes.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Mitochondrion. Peroxisome.
Sequence:
MTIEEVSGETPPSTPPSSSTPSPSSSTTNAAPLGSSVIPIVNKLQDIFAQLGSQSTIALPQVVVVGSQSSGKSSVLEALVGRDFLPRGNDICTRRPLVLQLLQTKSRANGGSDDEWGEFRHLPETRFYDFSEIRREIEAETNRLVGENKGVADTQIRLKISSPNVLNITLVDLPGITKVPVGDQPSDIEARIRTMILSYIKQDTCLILAVTPANTDLANSDALQIASIVDPDGHRTIGVITKLDIMDKGTDARKLLLGNVVPLRLGYVGVVNRCQEDILLNRTVKEALLAEEKFFRSHPVYHGLADRLGVPQLAKKLNQILVQHIKVLLPDLKSRISNALVATAKEHQSYGELTESRAGQGALLLNFLSKYCEAYSSLLEGKSEEMSTSELSGGARIHYIFQSIFVKSLEEVDPCEDLTDDDIRTAIQNATGPRSALFVPDVPFEVLVRRQISRLLDPSLQCARFIFEELIKISHRCMMNELQRFPVLRKRMDEVIGDFLREGLEPSEAMIGDIIDMEMDYINTSHPNFIGGTKAVEAAMHQVKSSRIPHPVARPKDTVEPDRTSSSTSQVKSRSFLGRQANGIVTDQGVVSADAEKAQPAANASDTRWGIPSIFRGGDTRAVTKDSLLNKPFSEAVEDMSHNLSMIYLKEPPAVLRPTETHSEQEAVEIQITKLLLRSYYDIVRKNIEDSVPKAIMHFLVNHTKRELHNVFIKKLYRENLFEEMLQEPDEIAVKRKRTQETLHVLQQAYRTLDELPLEADSVSAGMSKHQELLTSSKYSTSSSYSASPSTTRRSRRAGDQHQNGYGF
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFGQAVRRFATTAIRRSHYEEGPGKNLPFSVENKWRLLGMMTLFFGSGFAFPFIIVRHQLLKK
The following text describes a protein:
Function:
Required for colicin V production from plasmid IncFI ColV3-K30.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVWIDYAIIAVIAFSSLVSLIRGFVREALSLVTWGCAFFVASHYYTYLSVWFTGFEDELVRNGIAIAVLFIATLIVGAIVNFVIGQLVEKTGLSGTDRVLGVCFGALRGVLIVAAILFFLDSFTGVSKSEDWSKSQLIPQFSFIIRCFFDYLQSSSSFLPRA
The following text describes a protein:
Function:
Transcription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs). Binds to the GCC-box (NF-responsive box) of ENOD11 promoter. Acts as a transcriptional activator of NF-responsive box-containing target gene promoters in root hairs. Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation and maintenance, and nodule development. Necessary for NF-induced gene expression and spontaneous nodulation activated by CCAMK. Functions downstream of CCAMK to activate nodulation gene expression. Involved in early stages of root nodule development. Functions redundantly with ERN2. Is essential with ERN2 for the initiation of root hair infection, and nodule organogenesis and development. Required for accurate expression of the NF signaling genes ENOD11 and ENOD12.
Subcellular Localization:
Nucleus.
Sequence:
MEIQFQQPNMQNQKAGISVTNKGGKFKGRNRNSNNTNKFVGVRQRPSGRWVAEIKDTTQKIRMWLGTFETAEEAARAYDEAACLLRGSNTRTNFITHVSLDSPLASRIRNLLNNRKGDKKQEDGAVASAPSNSKTTISNTSTITSNDDNKESTLSTCATRNTELFEDAYKPDLSNCKEVFESGSQSNISCGFGPFFDHFSFTQLLDMAKNDDITDASSLELSEFERMKVERQISASLYAINGVHEYMETVQESNEALWDLPPLCSLFC
The following text describes a protein:
Function:
Has antiviral, antibacterial and anticancer activities.
Subcellular Localization:
Secreted.
Sequence:
MTYRCLLPMVLLLCFSTTALSRSYSLLRFQQRRSAEVCQKLLGQLHSTPQHCLEAKMDFQVPEEMNQAQQFRKEDAILVIYEMLQQIFNILTRDFSSTGWSETIIEDLLVELYGQMNRLQPIQKEIMQEQNFTMGDTTVLHLKKYYFNLVQYLESKEYNRCAWTVVRVQILTNFSFLMRLTASLRD
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MSSRGSGANAASRQSMTASGGAVKARQLAHLHSQLTQLSHNLATTENLMRMTAVQAEAMRGLGSWHAGLFMAASKVLGEESVQNQQGN
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication.
Subcellular Localization:
Nucleus.
Sequence:
MPEADRELVSIRRFLKERLQRDYTTLRGYAKERSNVRLLLQRTAEMGESNSLLLLGPRGSGKTTLINSVLADLLPNKSFGENTLIVHLDGNLHTDDRVALKSITVQMQLENAADGKVFGSFAENLAFLLQCLKAGGKHSKSVIFILEEFDLFCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRLDVIELLEKRVKSRFSHRQVFLFPSLRRFEDYVDLCGDLLSLPTGNSLLLAEKIYNLQNIQSGALYFSRNHFDPGEYGFSPRLRDAWNKQICKVLATQQARSTLQALHDFDISEAYLKNFLFRLVAHLRPQSPHITAEKMAAVGSQFEGDDKIELLCGLSVLELCLIIAIKHHSQIYDRDSFNFEIIYARFSKFAKVSTTMQAVERSIVLKAFEHLRIAELIMPLTGGAGGGVGKVQKEFEMHKLALTYSQIHHCMQRYQALPTEVAQWAQSSLI
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSMYLTLLFLVLILEMSVLFVLVLPLPFRIRRLFVRSYDKLQELGQLRTVGVILYGLVGMLFLDSWWRAQRATQRFSEGATQDPLNTGLQTFATKAYNERNLYISGFILYFSICIPTVINILKSLIRQYELGAAAAGDDTEEVKLLRQELKGKQASLTALRAQKKNLETHFDSSTESGPQDTAAKKAQ
The following text describes a protein:
Function:
Has antifungal activity against T.rubrum. Blocks voltage-dependent N-type calcium channels (Cav2.2 / CACNA1B).
Subcellular Localization:
Secreted.
Sequence:
MGAALKMTIFLLIVACAMIATTEAAVRIGPCDQVCPRIVPERHECCRAHGRSGYAYCSGGGMYCN
The following text describes a protein:
Function:
Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. The magnesium-chelatase is a complex of three subunits, CHLI, CHLD and CHLH. The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step. Does not bind abscisic acid.
Miscellaneous:
MISCELLANEOUS: Over-expression of CHLD has no impact on abscisic acid sensitivity.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAMTPVASSSPVSTCRLFRCNLLPDLLPKPLFLSLPKRNRIASCRFTVRASANATVESPNGVPASTSDTDTETDTTSYGRQFFPLAAVVGQEGIKTALLLGAVDREIGGIAISGRRGTAKTVMARGLHEILPPIEVVVGSISNADPACPDEWEDDLDERIEYNADNTIKTEIVKSPFIQIPLGVTEDRLIGSVDVEESVKRGTTVFQPGLLAEAHRGVLYVDEINLLDEGISNLLLNVLTDGVNIVEREGISFRHPCKPLLIATYNPEEGAVREHLLDRVAINLSADLPMSFEDRVAAVGIATQFQERCNEVFRMVNEETETAKTQIILAREYLKDVKISREQLKYLVLEAVRGGVQGHRAELYAARVAKCLAAIEGREKVTIDDLRKAVELVILPRSSLDETPPEQQNQPPPPPPPPQNSESGEEENEEEQEEEEEDESNEENENEQQQDQIPEEFIFDAEGGLVDEKLLFFAQQAQKRRGKAGRAKNVIFSEDRGRYIKPMLPKGPVKRLAVDATLRAAAPYQKLRREKDISGTRKVFVEKTDMRAKRMARKAGALVIFVVDASGSMALNRMQNAKGAALKLLAESYTSRDQVSIIPFRGDAAEVLLPPSRSIAMARNRLERLPCGGGSPLAHGLTTAVRVGLNAEKSGDVGRIMIVAITDGRANITLKRSTDPESIAPDAPRPTSKELKDEILEVAGKIYKAGMSLLVIDTENKFVSTGFAKEIARVAQGKYYYLPNASDAVISATTRDALSDLKNS
The following text describes a protein:
Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
MTSKLINFITIEKERFEDECVKFIKNVITDSINSRNIATIGLSGGSTPKPIYEMLGNDSSIDWTKVYFFAVDERYIDKSSKDSIYDLISKSVFKNRENLLVDHFITPNTSLPLKECIETYSNDLKKLIEKSNGSPDLVTLGMGEDGHIASIFPNSPKSPLDETDLVYHTTTERFAIFDRITTNINFLASSKNKVFFMSGSSKKKVWDEMESSQINVSRWPAHKIISSGNTNVFYRE
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for L-arabinose. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSSVSTSGSGAPKSSFSFGRIWDQYGMLVVFAVLFIACAIFVPNFATFINMKGLGLAISMSGMVACGMLFCLASGDFDLSVASVIACAGVTTAVVINLTESLWIGVAAGLLLGVLCGLVNGFVIAKLKINALITTLATMQIVRGLAYIISDGKAVGIEDESFFALGYANWFGLPAPIWLTVACLIIFGLLLNKTTFGRNTLAIGGNEEAARLAGVPVVRTKIIIFVLSGLVSAIAGIILASRMTSGQPMTSIGYELIVISACVLGGVSLKGGIGKISYVVAGILILGTVENAMNLLNISPFAQYVVRGLILLAAVIFDRYKQKAKRTV
The following text describes a protein:
Function:
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
Subcellular Localization:
Cytoplasm.
Sequence:
MRGTAGINAGTQLGIFLMCQPYLRCEPYNCNQCAVLLLPGLQCRHQILDPQTITPVLNARRKRQTLTAVKSSTRKRILSLKAHVAERRGEREELQDAHTICDLSQDCQPMPPDLLRLSYFAVFDGHGGTRASRFAAQNLHQNFVKKIPRGEGSSVDKAMKRCILDAFKQTDEDFLKQAASQKPAWKDGTTAICVLVADNILYIANLGDSRALLCRINKENQKHVVLSLSREHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRYGVISTPEVKRCPLTDSDRFILLACDGLFKAFSAEEAVTFILTHTQEKSSPAEDGPPDFDSLYESACHRLANEAVRRGAADNVTVLIVQIQH
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
RHLLLPSFGVQGQANLLKSSVLVIGAGGLGSPALLYLAACGVGRIGIVDHDVVELNNLQRQIIHTEAYIGKSKVESAAAACRSINSSTQIVEHKEAFHTSNALEIVSKYDVVVDATDNAPSRYMINDCCVVLGKPLISGAALGLEGQLTVYNYNGGPCYRCLFPTPPPTNACQRCADSGVLGVVPGVIGCLQALEAIKVSSLVGEPLSGRMLLFDALSGRIRIVKIRGRSLQCEACGEHPVLTRQTFPDFDYEKFTQTPLSTGPLKLNLLSQDARISSKEYNERVTKGEAHVLIDVRPAHHYKIVSLPNSINIPLSTLEGRLSEISAALEKEADKETLDGGSGASLYMICRRGNDSQRAVQLLHKAGFTSAKDIIGGLESWAHNVDPKFPTY
The following text describes a protein:
Function:
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
Sequence:
MSEFTNVTIIREANVYFDGGVVSRTVVFPDGTKKTLGIMQPGEYTFTTGAPEIMEILSGELDLKLPGSDAWNRVGGGESFDVPANSSFTMKVLSLTDYCCSFLG
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MTGGARKSSGASGGVSQRSINSFFAPKKPKKAPENQPIAKNPGAAEEEAIARVSTELPVLTATAKHNAGKEQGAPSLARDNQTTPKKQNGLLQTAPAAVRNGDSLRSSPRNVKTKEGSNTATPLGARLLSKRLEIFWPADQAWYWGVVEKYDSATGKHTVLYDDETVEELVLADEKLRWSDGGEVVDHVNSALAKSPPVVGRGLKRGRRRVTYLSEDDEDDGSDIKEQEKDADFVVELNDATAQADIEEEMMDMDNDEVSDDEGGGKKKQKKQAQKRRKTAKTLTPKKGAEQKNSTDASPGVENLPSAVPVIQPYTDGLNALQTRRSPDGSMLRAAIEAEKQEQKAAPPAAGVGVPELYGEASARFGTRVAEIFDFLLPKKRRDADGRRPGDEGYNPHTVSLTKDFLKKLSPGQRQWWEFKAQHLDKVLLFKMGKFYEMFEMDAHVGVQELNLIYMKGDQPHCGFPEKGFSPNAEALARKGYRVLVIEQVETPAQMAQRNKEKGTRDSVVRREVVSVLTKGTLVEADMLASHPEASYILSVTELAPTSERASDLENGSAVVGVCAVDTATSTFLVGQFVDDAHRGRLRSILAELRPVELIKPRGALDPATERALKDHTRQPLVNDLAPEDEFWTADRTKSELTTFFGSLELSTGESSWPPYLRRLAQSDADGAAAISALGGAVFYLRQALLESDVLALGRIEPLPGSADACLEAQAQKDDGRDVYMVLDSAALENLEILENNKDGGTSGTLLATLDHCTTAIGRRMLRAWLCRPLQSVKAITARQEAILDLKQGPGADAMGRAKRLLAGLPDLERLLARLHAVSSGSGRHADKVVLYEDEAKKKLGEFISILRGCKAVVDAVEGFQACKDKLTSPLLRRLVTIGELFPREVVPALEHFEEAFDWAQAEKEGRIVPTGAVDDKLDAAAERIAAVEGQLEEYLEEQKKKLKCRSITYVNVNKDRYLLEMPETTKVPLDFERGSGKKGVLRYHTPVVKDLLAELAEAEVEKEDALKGIFRKLLQHFCRDHSAWTAAIKAIAQLDALSSLAGASLCSDTPMCRPTFTPPSEESLGVPASFETPKASEAPQWLYAKGLRHPCLHSGATIASGGSFVPNDTCLGEPAGAPPFMLLTGPNMGGKSTLLRQVCLAVVLAQVGADVPAEAFSLSPVDRIFVRMGARDHIMSGQSTFFVELSETAAMLRSATRSSLVTLDELGRGTATTDGAAIAYAVLDHLAHSVGCRGMFSTHYHRLADEHADNPAIQLRHMACKVGESPTAGIEEVTFLYQLAAGACPKSYGTNVAKLAGMPDAVLARAAVKSAEVESTSDDLTAGSAKRKVGDGDEREPPLDQLERELLDRVTVALKGTGRPAASRELVEVWQEAKRASVESPQLLKRRRLEEDAFVRPEGVV
The following text describes a protein:
Function:
Transcriptional regulation of the polyketide synthase operon.
Sequence:
MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLGALRHYFSTQDELLAFAMKLVQEKVTDRIKDIAVRDLLPKEKVLQILLEMVPTNEETIREMEVWFAFTAYARHKKDMFDASHDGIFSGMRNLIAYLDESDLLKQNADKDIEAERLYALVDGLALHAMLDPVRVNKDRIKRVIMQHVESICVEDTRETQKRHP
The following text describes a protein:
Function:
Required for cytosine transport into the cell.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSQDNNFSQGPVPQSARKGVLALTFVMLGLTFFSASMWTGGTLGTGLSYHDFFLAVLIGNLLLGIYTSFLGYIGAKTGLTTHLLARFSFGVKGSWLPSLLLGGTQVGWFGVGVAMFAIPVGKATGLDINLLIAVSGLLMTVTVFFGISALTVLSVIAVPAIACLGGYSVWLAVNGMGGLDALKAVVPAQPLDFNVALALVVGSFISAGTLTADFVRFGRNAKLAVLVAMVAFFLGNSLMFIFGAAGAAALGMADISDVMIAQGLLLPAIVVLGLNIWTTNDNALYASGLGFANITGMSSKTLSVINGIIGTVCALWLYNNFVGWLTFLSAAIPPVGGVIIADYLMNRRRYEHFATTRMMSVNWVAILAVALGIAAGHWLPGIVPVNAVLGGALSYLILNPILNRKTTAAMTHVEANSVE
The following text describes a protein:
Function:
Sequence-specific DNA binding factor that recognizes the 5'-CCAAATTTTAAGTTT-3' sequence. Recruits the FRI-C complex to the FLC promoter. Required for FRI-mediated FLC activation, but has no effect on the expression of MAF1, MAF2, MAF3, MAF5, UFC and CO. Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development.
Subcellular Localization:
Nucleus.
Sequence:
MGKKKKRATEKVWCYYCDREFDDEKILVQHQKAKHFKCHVCHKKLSTASGMVIHVLQVHKENVTKVPNAKDGRDSTDIEIYGMQGIPPHVLTAHYGEEEDEPPAKVAKVEIPSAPLGGVVPRPYGMVYPPQQVPGAVPARPMYYPGPPMRHPAPVWQMPPPRPQQWYPQNPALSVPPAAHLGYRPQPLFPVQNMGMTPTPTSAPAIQPSPVTGVTPPGIPTSSPAMPVPQPLFPVVNNSIPSQAPPFSAPLPVGGAQQPSHADALGSADAYPPNNSIPGGTNAHSYASGPNTSGPSIGPPPVIANKAPSNQPNEVYLVWDDEAMSMEERRMSLPKYKVHDETSQMNSINAAIDRRISESRLAGRMAF
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MTVHNLYLFDRDGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFSIRSFVSKMSPVDMKDGFLAFQTSRYKLHYYETPTGVKVVMNTDLGVGPIRDVLHHIYSGLYVELVVKNPLCPLGQTVQSELFRSRLDAYVRSLPFFSARAG
The following text describes a protein:
Function:
This protein is probably a component of a manganese permease, a binding protein-dependent, ATP-driven transport system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLEFVEHLFTYQFLNRALITSIIVGIVCGTVGSLIVLRGLSLMGDAMSHAVLPGVALSFLFGIPMFVGALITGMIASIFIGYITSSSKTKPDAAIGISFTAFLASGIIIISLINTTTDLYHILFGNLLAITNSAFLTTIVIGSIVLILIIIFYRPLMISTFDPTFSRMSGLNTTLLHYFVMLLLSLVTVASIQTVGIILVVALLITPASTAFLISKKLYSMMIIASLISVISSIVGLYYSYIYNIPSGATIVLCTFVIYIITLFFTKFTNRKKRGSLT