lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the biosynthesis of agmatine from arginine.
Sequence:
MERWSINESAKIYNLPNWGADLFSINKKGNVCVHPSPTSKHSIDLRALVDDLIKRKIKPPILLRFMDVLQGRIASINRVFKNAIDENDYPATYQTFYPIKVNQQRQVVEAIAKFGKRYNIGLEVGSKPELVIGISFATGNGIPIICNGYKDTEYIETVLYATKIGYDITIVVEKMFELEKIIALSKKTGIKPKLGIRVKLSSKGTGKWATSGGEDAKFGLRMSEIIAAIGLLEQNDLLDRVKLLHFHIGSQITKIDKIKSALIEGTRIYAEMRKLGVGIRYVDIGGGLGVDYDGSKSSYFSSVNYSIEEYANDVIYQIKNICEDAGVECPNIISESGRATAAHYSVLVTNLLNTNTSNAMPDFEETLNGTEKLAPTVKKLVDIYKSIDRYSLREDYHDTVQLIQEAVSLFNLGYLTLNERAMAEWLHGKILRKINGIVEKIKPIPEELQNFQLSLRQTYFANFSLFQSIPDSWAIDQLFPIVPIQRLNQKPDVMASIADITCDSDGEITSFVGENGRTKYLPLHKMRKDEDYFVGFFLIGAYQEILGDMHNLFGDTNAVHVTFNKKTGYKIDTVIHGDATWESLKYVQYKGPEILKHVRDTLEKDVALRKVTIEESSHFLELLDRTLLGYTYLGE
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTLSSSQSSPPSTQNLKRKQQTISSFFTKRAPSAEKRSNDIEDGRATTQKGAEMPLRETAGDQNNLEDDEDGDVVVRAPKRVKTNGVDPENGFGRNIKEASNIARRPDPPLSSSQRTNLYKFASSQADDAGIEKTDDPEARQRQLEREKLHKLFVKKLGGADCLIGIGRDATTEAPSGTEDVAEGDEDDESPPQPRSKGKGLSKKGGSKLTPLEKQVIEIKRKHMDTILVVEVGYKFRFFGEDARIAAKELSIVCIPGKMRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVSAGYKVGVVRQLETAALKAAGDNRNAPFSRKLTNLYTKGTYVDDVEGLDGATPAASGGASPATGYMLCITETNAKGWGNDEKVHVGIVAVQPNTGDVIYDDFDDGFMRSEVETRLLHIAPCELVIVGELSKATEKLVQHLSGSKLNTFGDKVRVDRVAKKKTAVAESHSHVANFYAAKLKAANTADDAPASNLLQKVLNLPEQVTVCLSAMIQHLTEYGLEHIFELTKYFQHFSSRSHMLLNANTLVSLEIYQNQTDHSAKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKERLEERVNAVEELKSPERTVQAERLKIMLGKIKSDLEKNLIRIYYGKCTRPELLTVLQTLQTIAQEYVDVKTPQDSGFTSPILGEAIARVPSILGDVVKFLNKINMHAARNDDKYEFFRESEETEGISEHKCGIASVEHELEEHRSVAAGILKWPKVTYVTSSGIEYLIEVENSAAAIKRVPASWVKVSGTKKVSRFHTPEVIQLLRQRDQHKEALAAACDQAFAALLAEIASNYQSFRDCVQSLATLDCLLSLAAIASQPGYVKPEYTDQTCIHVEQGRHPMVEQLLLDSYVPNDIDLDSDKTRALLVTGPNMGGKSSYVRQIALIAIMAQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRTIRSLTLFITHYQHLSNMAQSFPDHELRNVHMRFTESGSGKDEEITFLYEVGEGVAHRSYGLNVARLANLPAPLLEVARQKSSELEERIRRRRLARLLADVGGLIEDPAKGDENFFQRLISNAEQL
The following text describes a protein:
Function:
Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MYMQVESRTGTLLHLKRNPSIRSWSLLVGILSVGLAAAYYSTDTWLWKLFYVAGCAFVALQNLEDWEEAVFDKKSGKAILTTYSIYKKLLTLCKGGQDQVVVLLKEIRDVNVAEERVRYFGKGYVIVLRFVTGISHPLTQSAVLGARSDVEAVAKELTKFLELDLVRTRSQAVEESSDSESDGALDKQ
The following text describes a protein:
Function:
Transcriptional repressor that binds DNA and plays a negative role in regulating microbe-associated molecular patterns-(MAMPs, e.g. flg22, elf18, chitin, and LPS) triggered immunity (PTI) by negatively regulating immune gene expression.
Subcellular Localization:
Nucleus.
Domain:
EAR motifs are involved in transcriptional repressor activity.
Sequence:
MALEQLGLGVSAVDGGENSSAPSNDGGDDGVKTARLPRWTRQEILVLIQGKRVAENRVRRGRAAGMALGSGQMEPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGDYKKIKEWESQIKEETESYWVMRNDVRREKKLPGFFDKEVYDIVDGGVIPPAVPVLSLGLAPASDEGLLSDLDRRESPEKLNSTPVAKSVTDVIDKEKQEACVADQGRVKEKQPEAANVEGGSTSQEERKRKRTSFGEKEEEEEEGETKKMQNQLIEILERNGQLLAAQLEVQNLNLKLDREQRKDHGDSLVAVLNKLADAVAKIADKM
The following text describes a protein:
Function:
Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the cyclization of aklanonic acid methyl ester to yield aklaviketone. It is also able to use nogalonic acid methyl ester as substrate, but produces exclusively auraviketone with C9-R stereochemistry.
Sequence:
MSEQIAAVRRMVEAYNTGKTDDVADYIHPEYMNPGTLEFTSLRGPELFAINVAWVKKTFSEEARLEEVGIEERADWVRARLVLYGRHVGEMVGMAPTGRLFSGEQIHLLHFVDGKIHHHRDWPDYQGTYRQLGEPWPETEHRRP
The following text describes a protein:
Function:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
Subcellular Localization:
Basolateral cell membrane. Membrane; Multi-pass membrane protein.
Sequence:
MSYYGSSYPIVSVDPKYPGYPPEHVIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSIFWLIAFQHGDLLNEPDVTPCVDNVHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALVGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGRMTMAFKDLRLVNDQIILVTPVTIVHEIDPESPLYALDRKAVAKDNFEILVTFIYTGDSTGTCHQSRSSYVPREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHNLEKAPPVRGAGPSDTKVRRRSFSAVAVVSSCENPEETTGPATDECKEAPYQKALLTLNRISVESQM
The following text describes a protein:
Function:
Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.
Subcellular Localization:
Mitochondrion.
Sequence:
MEPPWRVCFFGTDEFALEHLKKLHENQVAGDVKLVKSLDVVIPKSGKCIVGDYAERWNIRCMQWPIPSMVGTYDVGIVVSFGHLIPRSVIDSFPFGILNIHPSILPRWRGASPIIHTILNGDRETGISVMEIRPIHFDVGPLLLQSRFVIPDDCSTFQLRDYLSVEGSHMMMHALRDLPRLEKMEYEQNESGVTYAHKLSPVNARINWEEQSLTDIDRQYRALNEIYQLRSMWNKQKVKLLDMVPYPSILDSLEETFPEDEMTLRPGSAHYLKSHDILCIRCRDAWVGFGGIILKKPLSAKSFYNGYLSKYHLRSMTFDSMENALDKYTFRTTVSKSSLKTRAWV
The following text describes a protein:
Function:
Aerial growth, conidiation, and dispersal of filamentous fungi in the environment rely upon a capability of their secreting small amphipathic proteins called hydrophobins (HPBs) with low sequence identity. Class I can self-assemble into an outermost layer of rodlet bundles on aerial cell surfaces, conferring cellular hydrophobicity that supports fungal growth, development and dispersal; whereas Class II form highly ordered films at water-air interfaces through intermolecular interactions but contribute nothing to the rodlet structure (Probable). DewA is a class I hydrophobin that contributes to spore wall hydrophobicity.
Subcellular Localization:
Secreted. Spore wall.
Sequence:
MRFIVSLLAFTAAATATALPASAAKNAKLATSAAFAKQAEGTTCNVGSIACCNSPAETNNDSLLSGLLGAGLLNGLSGNTGSACAKASLIDQLGLLALVDHTEEGPVCKNIVACCPEGTTNCVAVDNAGAGTKAE
The following text describes a protein:
Function:
Involved in transport of proteins into the mitochondrion.
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MAELNTLVVRKPCFGLPTGCTQSLSAYIYLKFAQIPFQLDFHLNNPHSNQIPYFEVGDSVAYNNEKEGIIECLKKDVGVVDLDSGVSSLPEWISTKAILTTWLADALAYELWLGCEGSSAYSIYYSDLPWPLGKILSWKKAIWVKLKHGITNDNAEVKKEEIYERAKSAYEALSSCLGEQNYLFENRPSSLDAIFLAHGLVVLHALPESSMLRIKFSEHANLVRYVQQCKTELIDAAPSPSSAPQFHTDATSSASKSHSSSKPKSKPKREKTQEEKTFKRKAKYFVVAQLVAVVVFLTLMTSFDDAEVELDDDDGSYDYDE
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MADYMQHDRQMTHRGQQQPRAQQVIKAATAVTAGGSLLVLSALTLAGTVIALTIATPLLVIFSPVLVPAAITVVLLVFGFLSSGGFGVAALSVLAWIYRYMTGHHPPGSDQLDQARMKLSGKARDARDKGEHLINQATGGGAHGGTTHTTQ
The following text describes a protein:
Function:
Acts as a dual histone chaperone and heat shock co-chaperone. As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes. May also act as a histone co-chaperone together with TONSL. May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers. Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8. As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity. Exhibits activity to assemble histones onto DNA in vitro.
Sequence:
MGLIDLCQELFGSPDLYQVLRVSRGASGPAVRRGYYKVSMEVHPDRAPSDPRATEKFQTLGKVYAVLSDAEQRAVYDEQGIVDEEADSLQRDRCWEEYWRLLFPKLTVEDIVKFENKYKGSQEEKNDVHQLYLKFKGNMDKIMMSILCGTYEDEPRIRDLIQEGIDAEDLPDFKGTLAEKEKKEAEKLIKERKQNEEAEQLMKEQKQNEEKDQDLVAALQTRQKSREQEFNSLLSDLENKYCKKGAKGGKGKRPKKDPFGTWKITRAQMLINVKTLHHLFAFVQT
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MERKIFVSGVSLILVVGVALGVVALVRTNNGPADANNGGELTSHTKAVTAVCQNSDDHKFCADTLGSVNTSDPNDYIKAVVKTSIESVIKAFNMTDKLAVENEKNNQSTKMALDDCKDLLEFAIDELQASSILAADNSSVHNVNDRAADLKNWLGAVFAYQQSCLDGFDTDGEKQVQSQLQTGSLDHVGKLTALALDVVTAITKVLAALDLDLNVKPSSRRLFEVDEDGNPEWMSGADRKLLADMSTGMSVTPNAVVAKDGSGKFKTVLDAINSYPKNHQGRYVIYVKAGVYDEYIQIDKTKKNILIYGDGPTKTIITGKKNFVDGVKTIQTATFSTVAEGFIAKAMAFENTAGANKHQAVALRVQGDKSAFFDCAIRGYQDTLYAHAHRQFYRNCEISGTVDFIFGYASTVIQNSKIVVRKPEANQQNIIVADGTVQKNMPTGVVLQNCEIMPEPALQPDRLKVRSFLARPWKAYSRAIFMENTIGDLIQPDGFLPWAGTQFLDTCFFAEYANTGPGSNVQARVKWGKGVLSKADATKYTAAQWIEGGVWLPATGIPFDLGFTKG
The following text describes a protein:
Function:
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MLTEMETMVYGAEIKLSGSRGAWSGAAPSSCPDVDLEVIEEYLQENLLEIQPAHTSTSSITAVGQQAHTHQDSRIIENSWSGQHAYEWHCGSHAPIEEFKRLTPHPAWSSPHNNQWERIAYSYEAPAYIDSDSQSSSSQYQDYQDSPSPPSDSRDRKSRNSLPLPLSGKRKERLFQFLFEMLQTPSMRSCIWWVQSSSGTFQFSSQNKESLAQLWGRRKGNRKTMTYQKMARALRNYSRTGEIHKVKRKLTYRFDEKTLRGLQGNSNAL
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
Sequence:
MELSEDRNIDVPAVLTESCFSQRYREHLEKVGILDGRYRAQKLPGGTVALPVLENKLSVSLVVDLMEIVAPGSSCREMLIRNPVLSKRAAVKSPAQTLRNNVYKLLESHGLTWGRDLECDLPRSWQRHGDLVVLSEDCFRDPVWGQLGNELWVSVASSLGAGRLAKQGRVMDDGVRSPNVTLLLGENGWVEHVDNGIRYTFDITKCMFSAGNITEKQRVASLSCHGEVVVDLYSGIGYFTLPYLVHAGASFVHACEWNPHAVSALKKNLVINRVSDKCHIHEGDNRQLTLSDVADRVNLGLIPTSEPGYPVACRVLKKDTGGVLHIHHNVDCYGKSQGETDKDVSQTWRKIAWRNWAELVEKEISAMLEQVDGKKWQTRTLRLEKIKSYAPHVDHVVLDLDCRPLPSI
The following text describes a protein:
Function:
Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAAKSDGRLKMKKSSDVAFTPLQNSEPSGSGPGPGPGPPSGAEGDEAAGPGEGRPRQRRRRRRCRCCCCCCCGGPAASSVAGPGPGSPSPAGARRRYSPWDCLWLLAAAAVYFADVGTDVWLAVDYYLRGQRWWFGLTLFFVVLGSLSVQVFSFRWFAHDFGADDPAAGPQPPAEAKAEPPDGGGGGGGGGGGGEREPRPSTPHGQPSDATGTGRRARSASCAFCVWLLQSLVHVLQLGQIWRYFHTIYLGIRSRRSGEHDRWRFYWKMVYEYADVSMLHLLATFLESAPQLVLQLCIVVQTHTLQALQGLTAAASLVSLAWALASYQKALRDSRDDKKPISYMAVIIQFCWHFFTIAARVITFALFASVFQLYFGIFIVLHWCIMTFWIVHCETEFCITKWEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENSALSALWYLYKAPQIADAFAIPALCVVFSSFLTGIVFMLMYYAFFHPNGPRFGQSPSCACEDPVTAFTLPPEVATSTLRSISNNRSLSSDRDQKFVERDGSTPVFQVRPTAPSTPSSRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAILAFECSPAPPRLQYKDDALIQERLEYETTL
The following text describes a protein:
Function:
Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to oxidative stress and probably also to the osmolarity of the extracellular environment. Involved in cell wall biosynthesis, hyphal growth, and virulence. Regulates the expression of CHK1, as well as of a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Provides at least partial adaptive functions for the survival following encounter with human neutrophils.
Sequence:
MNFLYNNSDYSSTSHTMKSPSAYNQFPKLQASNSTAGNNNTATTATAAAAAASASASASVTPQLISPTTLTTPQNKYKRGGLDNTLPKIETTRKNRPDDGNSITPSNSINSGTTKLTLPPRRVWVKKPQTNNPTTVLCYVNDIIDDLKVAVVNKYPNTIGRYEDAADLLVKIDLNNIRVPVSPSVNRVSQRTPFDNCIILEPDQNVWQILDNYFPNGMAMHDALIIETPTFKPDHQMLTPITANMNNNSNTFIPFQERQSSIGNNNNNNSNVNNNNKAQAVKHPQPMQPNNTRVGLHKSYAMNRSSFSTNNNPVPSIIKDRSVSPSNLGVSRNSPVSHKRSYSNPVSSPNSVATQANNPSAVLLLPRNFSLANNNSNQASQSSGGTPAKKVLSEDGSKSVNDKTEEVVSSKLKPNDNNKSYQAKQQEQQTAEQSENGFSETSASPEAVHNSKAAPLPLTKSSTTATTTSSNSISNNNNTSSKGKPSQSKLKAANDPTPTDIVLPSISVLVVEDNAINQAILGAFLRKRKIHYQIAKNGQEAIDKWKKGGFHLVLMDIQLPVKSGIEATKEIRHLEKLNRIGVFHENEIGKNVIINEEDRLTSNTFRSPVIIVALTASSNSSVDKTNALTAGCNDYLTKPVNLVWLQNKITEWGCMQALIDFDGWKDKNRRLNKA
The following text describes a protein:
Function:
Sex-determining factor that is required for sexual differentiation and X chromosome dosage compensation to promote male development. High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear.
Miscellaneous:
MISCELLANEOUS: [Isoform b]: Only functional isoform. Produced by alternative splicing of intron 6 which results in the deletion of intron 6 and retention of exon 7 coding sequences; MISCELLANEOUS: [Isoform c]: Inactive isoform. Produced by alternative splicing of intron 6 which results in the retention of intron 6 and deletion of exon 7 coding sequences. An in-frame UAA stop codon within intron 6 prematurely terminates translation. Intron 6 retention and exon 7 deletion can also be due to use of an alternative 3' splice acceptor site in the 3'UTR resulting in trans-splicing to the transcripts of unrelated genes.
Subcellular Localization:
Nucleus.
Sequence:
MQVEANSERRVKILGIDRSENSPVLTYMETEDDPNFRNSKLAAAPHTVHMMDSGFLAINRQCLVKGKAILAREPKSSNEHMIDDLPKHAHDQHTLSILRDFIDQLKLHNVYEINFYDPLDSSGKLAVIPMLIALWKCMLASETDICDQEVLKSIMNSVIAKFELQIPCKNAVIDATLSGSREEVHIIAEDGSLENSNGTTEHFNKKHDLVFVKTDLHPEDFTPQMFPSQAKAKLLRDAFNNEEDEDTFPDILVPAYMTAHSKNRVRQEDYTCLEVEFDSQVALEKLMNEHEQVEGFEVQQGGILVALKKDSFFDDELIEKIAIAIATESRQSVSSVSFDLLKLGPGASLVTLANSRRFEPECRVVLQIEVKPVSPGETSSEGISDEHHYEEYDEDDIMEEEEAPSARQDDTYDEDEE
The following text describes a protein:
Function:
Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.
Subcellular Localization:
Secreted.
Sequence:
MVPAACMLLWALLLSLEYRAAGAEDQTTTPTATTIGMQRVSFRFGGPARSLHSTNPTARTTVPGKLRVTLEDENDALATADRLALPAAAELLSTVTGYSRSSVPSPSDWEEDGSLEEGVVDTRKTTNGPVSLFSTTNTVGSSGTTGRFLANSQEREIKLTTDVRSLSSKTTVVDLSSESTLQQWSTPGSTPSPWLKPSFTAMPSPEDLRVVLMPWGPWHCHCKSGTMSRSRAGKLHGLSGRLRVGALNELRTEHRPCTYQLCACNRHLEECPLDSSLCSDHSCSSRAPFQSSTTSLVPVHLRRRPILPPTSPSPSPALAFWKRVRIGLEDIWNSLSSVFTETQPVERIQR
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MRCGGSTPARKRGMFHHRCRVAVPHALPRRGRFFSGFCMHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLFLPPLLFLDGWRIPKQGLFRDKAAILELALGLVVFTVVGAGLLIHWLIPAMPLAVAFALAAIISPTDPVAVSSIASKVQIPKRLMHILEGESLLNDASGLVCFQFAVAAVLTGTFSVATASLTFLWVALAGLGLGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHASGILAAVAAGITMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAVRSVQEAGHLNPWWLAVYVATISASLMALRFVWVFLSLRWNLFKAQRRGEAHVSPPWRIVVAVSLAGVRGAITLAGVLTLPLVLEDGSPFPARQLAIFLAASVILVSLLVASVALPRLLRGLELPEEEDEQLKEDLAVKAASQAALEAVEKLRQRLVEDSAHAERYNAAANQVSQRYQRKLGAVDMAETDPEEAGAFEQALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIESRKRA
The following text describes a protein:
Function:
Transcription factor. Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C. Positively modulates transcription of KDM5C. Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. Required for normal brain development. Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain. May also be involved in axonal guidance in the floor plate.
Subcellular Localization:
Nucleus.
Sequence:
MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLASRADQEKAVQGSPKGSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAATATAGPRGEAPPPPPPTTSRPGERPDGSGAAVAAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPGGAAHPDERLGAAGGPGGAPAGSSGTGAEDDEEELLEDEEDEDEEEELLEDDEEEMLEDDARALLKEPRRCAVAATGAVAAASAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, a precursor for Pseudomonas quinolone signal (2-heptyl-3-hydroxy-4-quinolone; PQS) production which is required to induce the genes for the biosynthesis of the virulence factor pyocyanine (PCN), a characteristic blue-green phenazine pigment produced by P.aeruginosa. In the first step, the glutamine-binding beta subunit (PhnB) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (PhnA) to produce anthranilate (By similarity).
Miscellaneous:
MISCELLANEOUS: PhnAB is not feedback inhibited by tryptophan.
Sequence:
MRITLLDNFDSFTYNLVEQFCLLGAEVRVMRNDTPLPTIQAALLADGCELLVLSPGPGRPEDAGCMLELLAWARGRLPVLGVCLGHQALALAAGGAVGEARKPLHGKSTSLRFDQRHPLFDGIADLRVARYHSLVVSRLPEGFDCLADADGEIMAMADPRNRQLGLQFHPESILTTHGQRLLENALLWCGALAVRERLRA
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAESRSAAQRLYLSVYNWVSFFGWAQVLYYATLALLGGGHETVYAAVKLPLLFSQTAMLTEILHSILGFVRSPVIATSTQVCARTLVTWAIVWTYPETHSHILITSLVLSWSITELNAGHQIFILWFEGGIWNYTFLAPMAQVHHFHGALPYWAYQRGWLNLHCHASHEGKSTINMGSFNLSLHSRIPLHVLLHALPAEEGLVEGENRIT
The following text describes a protein:
Function:
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MDMLKWIFRGLIIVFVSYIIYIVGYPFMVDVSSLKKKNPELTAMMKYRIKQWERDGKKIKIKKMWIPVNRVSPYLVKAVLIGEDDKFYSHSGFDIEGIKKAIEKDIKEKKLKYGGSTITQQLAKNLYLTPSKNPVRKIQEAIITWRLEKTLSKKRILELYLNVAEWGEGIFGAEAASRHYFGKSASELNAIEAARLAASLPNPIKYSPVGNSRFIEKRTNLIYFIMQKRGIIKEEYTEPEEKDSVPVLEEKQEEKELPSIQKDESVQPQLK
The following text describes a protein:
Function:
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Sequence:
MPKPTFVVLFCFAASMNTQSSGHKTAVDHGVQIRFIDNIGDGGRHPAPQPRNKPPSSSKYGVAVRVQGIAGQPYVVLKDGQKGDSYGVQLRTDYGPDYRSLPRRTVKPGLGVEETYGETGEGGGQGGVLRRAQSHGSLLDRDGVPAIEDFELSRPPGDGKSGSYGNLDGGIGVRGNNEETWAASGREGPVERRMWGGSYQATNLSRSQESLRDSQLNPYPPQKVHEFQVNQRQSAFSRLKNRFDGGAPASQQSGLPPVLQPPRATSPYTSQSPYTSPPSSTNSSLGRNQGSVVASRSSSQWSSKERLQVDLPDTRATPDLLLDQVQSAEMSSEEEQLMKNLYSILKQGSNERDVVIRQKVEAIYLNLQSLKPKESPHEEWMRAKRELETKVAELQTALQEERRESARNSDPALKGELESCLDENLHLQELLSRKNTELNETQSELTQLRMDRDGAEKHIRDMEDQLAELQEELRRENGSKTDLMSCQTQLMEVCQLKQKLEDALRQRERELTALKGALKDEVASHDREMEALRQQYGADMEKLRSNMEQVSQSQAGIEAERLRVNTSVRSLQKQLEDCRDESSHWMEQFHATRDELRSAKQEELPSHPEPQLLQTRLEKDELEDELKELKDKLSMMKQQTPDPKHTEILSQELQRSSGDLQKVKSELEKQRVNFDKKVMEVISLKKSHQNQEAELRYEIDRLKEQLQRAKEDIAKAQEKNKKLPNPATVSDLEQKLGEAQREASRLKEKLSETEQELETIKSHLNRAQADVDSLRETQSDQEATNSRLKEKLSRLEAQLQSSAAESSEAELSLHAEMRGLRSELDEAKRRLSKLNQERQELSLRLENSERDKEALKQTVSQLEDTKSQLGKALDKLNKDYESLKLSSKEEVHALSAQLEEQRERARKEMQDAQRHGKDAQSELEKHHANLKRLEEEMLRQKKELQLACEERDNHQLDKELLSNRLRHLEGELEASKNSHNEKAREVRILEDKLKCMELECEEEKSTVEMLTERVSRSRDQIDQLRSELMQERSSKQDLELDKNGMERQLKELRSRVAEMEGQSRSSAGVSQLENKIQELEERLRFEEREKNSVLASQRRSERKLKELNMTLDEERHAHTEQRDQLALKVKALKRQVDESETELERIEGLRRKAQRDMEEQMELKESLQARVTALETELKRKTQAAMRQALDSSALSSDDDDSLYDHSTITSILTEGNLQTSSC
The following text describes a protein:
Function:
Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells. Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side of the FE cells. This function is independent of the Crag/Rab10 regulation of polarized BM protein secretion in the FE.
Miscellaneous:
MISCELLANEOUS: The name stratum (strat) refers to the geological term for a layer of rock as mutants accumulate basal membrane proteins as a continuous apical sheet/layer. The name also highlights the similarity of the mislocalization phenotype to Crag mutant cells, as both names are based upon geological descriptions of rock formations.
Subcellular Localization:
Basal cell membrane; Peripheral membrane protein. Note=Diffuse intracellular localization early in oogenesis which later becomes basally enriched in follicular epithelial cells.
Sequence:
MTEEADFSEQITDGKNKSNVRCQFCNCLMLKAQEGTYNQEEVDVPLMTQKQDRTADSLNSEPLKDFWLVKDMMTFENIGFSNTVDGRKFLVCADCERGPVGYHDLSTRHCYLALKRVVHKDT
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVFEKVQEIIVEELGKDASEVTLESTFDDLDADSLDLFQVISEIEDAFDIQIEAENDLKTVGDLVAYVEEQAK