lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Zn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Recruited to the cell membrane in response to low extracellular magnesium.
Sequence:
MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD
The following text describes a protein:
Function:
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Subcellular Localization:
Nucleus.
Sequence:
MKENKENSSPSVSSANLDHAKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKQRNNPLHRGSSETGHTECSHMHTEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLPQPPSLHSTPPGPTSQQPQSSQSSEQSQPQQPKEPQQAAQQPPPPPQPPQQQPPPPQTQPPKKPSPQSSPPRQAKRPVVVSPKEESKSAEAPPAKVAKMEPAHPPIPPVHQPPEHKPPLTTAVSMGGDQSSIVDSVDIAKVQIAPPSHPAPVHQPPPMPHRPPPPPPPSSYITGMSTTNSYMSGEGYQSLQSMMKTEAPTYGALPPSYGPPSHMPYHPHVYPPNPPPPVPPPPPTSFPPPTIPPPAPGYPPPPTYNPNFPPPRLPPSHAVPPHPPPGMGMPPANYPPPSVPPGGQPPVPPPIPPPGMPPVGGLGRATWMR
The following text describes a protein:
Function:
Transcription factor involved in endoplasmic reticulum (ER) stress response. Acts as a ER stress sensor and activates the transcription factor BZIP50 and the chaperone BIP1.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus.
Sequence:
MALAEASPFADLPFPDDLPEFPHPGDDAFALDGFDLDDLDIDFDFDLDLDLLPTDDVQLPSPPPPLATSSSSAGSPGGAGDSSSGSGGGADGALKNDESSETSSRSASAGSDGKAKDGEGEDDKRRARLVRNRESAHLSRQRKKQYLEELEGKVKAMQATIADLSTRISCVTAENAALKQQLAGAGGAGVPPPLPMYPGLYPLPPPWMHPAYAMGARGSQVPLMPIPRLKTKQPASAAAEPPAKKSRKTKKVASVSLLGLLFLMMLCGCLVPAVNRMYGPVDSREGIVLGPSQSRHGRVLAVDGPRDVSEGVDSKLPHNSSETLPALLYIPRNGKHVKINGNLVIQSVVASEKASSRMCHSDGKTSCNQGQEDTSLAIPGHVAQLNSGEVMESAKAIKNKLMALPPGDGSIYREDDELLPQWFSEAMSGPMLSSGMCTEVFQFDISPTTIVPVYSSGMHNASHNSTENLPSSQSHKVKNRRILHSMAIPLKGSTSNHTDHLKAHPKNESFAGNKPASSVVVSVLADPRVDADGRISSKSLSRIFVVVLVDSVKYVTYSCVLPFKTHSPHL
The following text describes a protein:
Function:
Could be part, together with LetB, of a system that transports lipids between the inner membrane and the outer membrane (Probable). Contributes to membrane integrity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MALNTPQITPTKKITVRAIGEELPRGDYQRCPQCDMLFSLPEINSHQSAYCPRCQAKIRDGRDWSLTRLAAMAFTMLLLMPFAWGEPLLHIWLLGIRIDANVMQGIWQMTKQGDAITGSMVFFCVIGAPLILVTSIAYLWFGNRLGMNLRPVLLMLERLKEWVMLDIYLVGIGVASIKVQDYAHIQAGVGLFSFVALVILTTVTLSHLNVEELWERFYPQRPATRRDEKLRVCLGCHFTGYPDQRGRCPRCHIPLRLRRRHSLQKCWAALLASIVLLLPANLLPISIIYLNGGRQEDTILSGIMSLASSNIAVAGIVFIASILVPFTKVIVMFTLLLSIHFKCQQGLRTRILLLRMVTWIGRWSMLDLFVISLTMSLINRDQILAFTMGPAAFYFGAAVILTILAVEWLDSRLLWDAHESGNARFDD
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSFLLPLVIFFLFFFHLIKSYNINYHINDKTFFPYQQKHQIKKKKKNYIKYDGKGIILLKDSKEGNSLNFKVEDFLCESEKKEKNKNKESHGSFFFQTNTTFSELNIHKLLIENLKNHNINTPSVIQYDLLKYYDEHNDNLQNIIIAAENGIGKTLSYIIFLINHILKKGTNKNTCTLILQYNNLLCNQCYDLLKKLSKNVKAQIVNLKYEGIINIKNHLIVICTPVRLISYIKEDKENVFSTFFENLDFLIMDEVDILFDNPYIRNMKIIFDELNKLKNEKSVSIITSSTLCNKGKKSIYNNVIKYITNPIVIKTNYFHNIHPFINYHFIKASNYYIKNKVQIIKHILSKQNYKKVLIFCNTLKSSNTAFSLLKLHFDNIFLFNSTVTKEDQTIILNHFKNSQNPILVTTDIIYRGIDISNISHLFHFDTPTNIVVYTHRNGRLARGANTGHVYIFKHFEDLVTRKIYELHKNKLKFEEIFSRKRSLRKNYKRELQKKSEK
The following text describes a protein:
Function:
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis. Essential for lipoprotein maturation under conditions where membrane fluidity may be altered; (Microbial infection) Involved in phage C1 and phage C6 infection. Participates in phage DNA transport pathways in cooperation with different outer membrane receptors, including FhuA and BtuB. Is probably required in the second stage of phage adsorption, the DNA injection process. Participates in the formation or opening of diffusion channels through the outer membrane after phage adsorption. DcrB probably only increases the efficiency of SdaC/DcrA action.
Subcellular Localization:
Cell membrane; Lipid-anchor; Periplasmic side.
Sequence:
MRNLVKYVGIGLLVMGLAACDDKDTNATAQGSVAESNATGNPVNLLDGKLSFSLPADMTDQSGKLGTQANNMHVWSDATGQKAVIVIMGDDPKEDLAVLAKRLEDQQRSRDPQLQVVTNKAIELKGHKMQQLDSIISAKGQTAYSSVILGNVGNQLLTMQITLPADDQQKAQTTAENIINTLVIQ
The following text describes a protein:
Function:
Protein kinase that is necessary for a-locus-dependent processes, such as conjugation tube formation, filament formation, and maintenance of filamentous growth, and for a-locus-independent processes, such as tumor induction and teliospore germination.
Sequence:
MLSSGAGSSIRKKRNFKGLQLAESPLASPVDASATTPSHKPGEGSAASNASTIGKSSAVTPGGSLALPVKNGLDTEPNSGANYHNKLTQQLANLELGVEYKLDLKNEDLKTLSELGAGNGGTVTKVLHEKSGTVMAKKVVFIDAKPSVRKQILRELQILHECNSPYIVSFYGAYLNEPHICMCMEFMQKDSLDGIYKKYGPISPEICGKIAVAVSHGLTYLYDVHRIIHRDVKPSNILVNGAGQIKICDFGVSGELINSIADTFVGTSTYMSPERIQGDQYSVKSDVWSLGVSIIELALGRFPFAENEEDDDSDADNNYTNEDLAGTLSPTKPAPMISLGQNEKQRRRKSKPAGVSLEGSSHQMSILDLLQHIVNEPPPKLPEGRFPKHMEEFVNLCLLKDPAKRPTPKDLTKHQYVIDADAAKVDLQAWADGMK
The following text describes a protein:
Function:
The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.
Miscellaneous:
MISCELLANEOUS: Present with 8760 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches.
Sequence:
MPDSKYTMQGYNLVKLLKRLEEATARLEDVTIYQEGYIQNKLEASKNNKPSDSGADANTTNEPSAENAPEVEQDPKCITAFQSYIGENIDPLVELSGKIDTVVLDALQLLKGGFQSQLTFLRAAVRSRKPDYSSQTFADSLRPINENIIKLGQLKESNRQSKYFAYLSALSEGAPLFSWVAVDTPVSMVTDFKDAAQFWTNRILKEYRESDPNAVEWVKKFLASFDNLKAYIKEYHTTGVSWKKDGMDFADAMAQSTKNTGATSSPSPASATAAPAPPPPPPAPPASVFEISNDTPATSSDANKGGIGAVFAELNQGENITKGLKKVDKSQQTHKNPELRQSSTVSSTGSKSGPPPRPKKPSTLKTKRPPRKELVGNKWFIENYENETESLVIDANKDESIFIGKCSQVLVQIKGKVNAISLSETESCSVVLDSSISGMDVIKSNKFGIQVNHSLPQISIDKSDGGNIYLSKESLNTEIYTSCSTAINVNLPIGEDDDYVEFPIPEQMKHSFADGKFKSAVFEHAG
The following text describes a protein:
Function:
CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
Sequence:
MGGAIMRPSLEGIENPPPTAHGGAIASPAKRSGLAVRLLVLAGIGLAGVLVFVLTRPAPEASEAARPPAALSVTVEPVQKRLLARTLMVTGSIAAWDELPIGAELTGLRIEGVYVEEGERVQRGQLLARLNDRPLRAQIRQVEAEIARGRALIAQSRANFAEARALRGEAEANRHRFDDLQRQGAISEVEATARRTSADTYGARLGGASQAIAVAESDLARAEARREELLAMLAQTRITAPAEGLISKRQAKLGSVVSPLSAQALFTLVRDRRLELQAEVSEVRLGAIAPGQAVAVQTDALPERRFAGRVREIAPAVDAGSRNALVKIDLPLDPALRPGMFARGELRFGAGPALAVPEGALIFDNGRAHLFVVQGEKAVRRAVETGARSGGQVEITGGLAAGEQIVLAGAGYLKDGARVRTAGGAS
The following text describes a protein:
Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions.
Sequence:
MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFRVPHQEENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISLGCPASKTEAEGGDDDLQTTEEDTSRSLVKDHFFQQETVVTSEPYRSSDIRPLPFEDLNARRVYLQSQVSQIPFSQQGLDIQSRSMEYVQRQISKECGSLKSQTRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDTDSSVPFSKQDSKKSDYLYHCGDETKLSSLKDSVVFKTQPPSLKFKSKRRKEDGERSRCVYCQERFNHEENARGKCQDAPDPVKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG
The following text describes a protein:
Function:
Activator of yeast transcription factor, STE12.
Sequence:
MQSSVYRDKASSIAMILETQRNVEFPHRIVDKRPRKRPRLTWDAAPPLLPPPPPPTVFQPPLYYGPEFASGLVPNFVYPNMFYNGLPRQGSPPWRPDDKDGHYVFVVGDTLTPRYQILSKMGEGTFGQVLECFDNKNKEVVAIKVIRSINKYREAAMIEIDVLQRLTRHDVGGSRCVQIRNWFDYRNHICIVFEKLGPSLYDFLRKNSYRSFPIDLVRELGRQLLESVAYMHDLRLIHTDLKPENILLVSSEYIKIPDYKFLSRPTKDGSYFKNLPKSSAIKLIDFGSTTFEHQDHNYIVSTRHYRAPEVILGVGWNYPCDLWSIGCILVELCSGEALFQTHENLEHLAMMERVLGPLPPHMVLRADRRSEKYFRRGAKLDWPEGATSRDSLKAVWKLPRLPNLIMQHVDHSAGDLIDLLQGLLRYDPTERFKAREALNHPFFTRSREQSIPPFNPNPHPFLYNQKN
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Nucleus.
Sequence:
MEGAKRADANLLTDTGTESSPRSPVCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLVRNTCEAVVLGALHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVTCALDSDGNLVLDPTTKQEKEARAILTFALDSAEQKLLMSTTKGLYSDAELQQCLAAAQAASQHIFRFYRESLQRRYSKS
The following text describes a protein:
Function:
Transcription factor that is involved in the preservation of the spiral phyllotactic arrangement leading to a regular pattern of organ initiation. Required for maintenance of stem cell fate in the shoot apical meristem, and is essential for specifying floral primordia and establishing early internode patterning events during inflorescence development. Acts as a transcription repressor of AG expression in floral and inflorescence meristems. Is also responsive of the nuclear import of SHOOT MERISTEMLESS (STM). In the fruit, plays a central role in patterning by negatively regulating SHP expression in order to prevent replum cells from adopting a valve margin cell fate.
Subcellular Localization:
Nucleus.
Domain:
The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.
Sequence:
MADAYEPYHVLQQSRRDKLRIPSLDSHFHFHPPPPPSSGGGGGVFPLADSDFLAAGGFHSNNNNNHISNPSYSNFMGFLGGPSSSSSTAVAVAGDHSFNAGLSSGDVLVFKPEPLSLSLSSHPRLAYDLVVPGVVNSGFCRSAGEANAAAVTIASRSSGPLGPFTGYASILKGSRFLKPAQMLLDEFCNVGRGIYTDKVIDDDDSSLLFDPTVENLCGVSDGGGGDNGKKKSKLISMLDEVYKRYKQYYEQLQAVMGSFECVAGLGHAAPYANLALKALSKHFKCLKNAITDQLQFSHNNKIQQQQQCGHPMNSENKTDSLRFGGSDSSRGLCSAGQRHGFPDHHAPVWRPHRGLPERAVTVLRAWLFDHFLHPYPTDTDKLMLAKQTGLSRNQVSNWFINARVRVWKPMVEEIHMLETRQSQRSSSSSWRDERTSTTVFPDNSNNNPSSSSAQQRPNNSSPPRRARNDDVHGTNNNNSYVNSGSGGGSAVGFSYGIGSSNVPVMNSSTNGGVSLTLGLHHQIGLPEPFPMTTAQRFGLDGGSGDGGGGYEGQNRQFGRDFIGGSNHQFLHDFVG
The following text describes a protein:
Function:
Transcriptional regulator which promotes dendrite growth by suppressing, either directly or indirectly, the expression of the microtubule-severing protein spas. Determines multipolar neuron morphology in postmitotic neurons by positively regulating the expression of genes involved in nuclear positioning including several dynein genes and the nuclear migration protein nudC.
Subcellular Localization:
Nucleus.
Sequence:
MHTDIIIGDQFAANNNYWVMQSPELDYRHELMGRLHKIEPADVELEVLAAAAAAANNNNNTSSNNNHSSNSSSNNSNGSQTPNGNNNSSLATGGHQHHQFHHHLHHHHSHQHHHQHHHLHQHHSHSLQSGESGASEAWPHLPAPSYASDVPHAQQQQLQPAGSPNSNSNGAYGCAPLYDGAPYEVALGYGGAVVASTGGATSSDKEYLYETKNKEALYADPLDDPYQRPVLWDDITTSIQNIDPENALMLSSSGSSNNNGSSNSSSNTGESATSQLPQVKMEAIDESLLETFSTPLLSPLEIKTEKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQQYQQQHYQQHYQQQHLYQHHPSLALPGLPPAVDVVELQLQQQHQQQQHLQHNNSSSSSPKLATPGDNSGNTSSYQQQYASQLVSGSGGGYLNGSSSNSYGYSWHSSQSFHTKYQIHPPSAAASATASATATPTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFVPPLTPPSSDPGSPGSSMVAAAAAAAAQRRTTPPPPYQQGHVMGLINPPPTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQVPQQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPKNK
The following text describes a protein:
Function:
Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
Subcellular Localization:
Secreted.
Sequence:
MKADPVPRWKAGGLFLVGLLALASASDPAVYTNHFLVEFHHGGEAEAAQVAAAYGFHGVRKLPFVEDGYHFFHNGLAKGRRRRSLQHQLRLEKDPRVKKAVQQIGFGRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAQASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGRTYIKILCLICLYRLNLTRCIPPFQGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANADLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVTMAKDWKTVPERFHCVGGSIQEAQKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHSWGEDPRGTWVLEVGFVGILPQKGVLKEWTLMLHGTQSAPYIDQIVKDYQSKLAMSKKEELEEELDEAVERSLKSILSKN
The following text describes a protein:
Function:
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRAVCPGSFDPITNGHLDIIARASSLYDEVYVAVMINQAKKGLFEIEERIDLIRRVTAEYGNVRVESFHGLLVDFCKQREIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFIPTNPTYSFLSSSLVKEVATWGGDVAHLVPPLVLEALTERLRNR
The following text describes a protein:
Function:
Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein.
Domain:
The chorein N-terminal domain mediates lipid transfer activity.
Sequence:
MPWPFSESIKKRACRYLLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESADAPLEVTEGFIQSISLSVPWGSLLQDNCALEVRGLEMVFRPRPRPATGSEPMYWSSFMTSSMQLAKECLSQKLTDEQGEGSQPFEGLEKFAETIETVLRRVKVTFIDTVLRIEHVPENSKTGTALEIRIERTVYCDETADESSGINVHQPTAFAHKLLQLSGVSLFWDEFSASAKSSPVCSTAPVETEPKLSPSWNPKIIYEPHPQLTRNLPEIAPSDPVQIGRLIGRLELSLTLKQNEVLPGAKLDVDGQIDSIHLLLSPRQVHLLLDMLAAIAGPENSSKIGLANKDRKNRPMQQEDEYRIQMELNRYYLRKDSLSVGVSSEQSFYETETARTPSSREEEVFFSMADMDMSHSLSSLPPLGDPPNMDLELSLTSTYTNTPAGSPLSATVLQPTWGEFLDHHKEQPVRGSTFPSNLVHPTPLQKTSLPSRSVSVDESRPELIFRLAVGTFSISVLHIDPLSPPETSQNLNPLTPMAVAFFTCIEKIDPARFSTEDFKSFRAVFAEACSHDHLRFIGTGIKVSYEQRQRSASRYFSTDMSIGQMEFLECLFPTDFHSVPPHYTELLTFHSKEETGSHSPVCLQLHYKHSENRGPQGNQARLSSVPHKAELQIKLNPVCCELDISIVDRLNSLLQPQKLATVEMMASHMYTSYNKHISLHKAFTEVFLDDSHSPANCRISVQVATPALNLSVRFPIPDLRSDQERGPWFKKSLQKEILYLAFTDLEFKTEFIGGSTPEQIKLELTFRELIGSFQEEKGDPSIKFFHVSSGVDGDTTSSDDFDWPRIVLKINPPAMHSILERIAAEEEEENDGHYQEEEEGGAHSLKDVCDLRRPAPSPFSSRRVMFENEQMVMPGDPVEMTEFQDKAISNSHYVLELTLPNIYVTLPNKSFYEKLYNRIFNDLLLWEPTAPSPVETFENISYGIGLSVASQLINTFNKDSFSAFKSAVHYDEESGSEEETLQYFSTVDPNYRSRRKKKLDSQNKNSQSFLSVLLNINHGLIAVFTDVKQDNGDLLENKHGEFWLEFNSGSLFCVTKYEGFDDKHYICLHSSSFSLYHKGIVNGVILPTETRLPSSTRPHWLEPTIYSSEEDGLSKTSSDGVGGDSLNMLSVAVKILSDKSESNTKEFLIAVGLKGATLQHRMLPSGLSWHEQILYFLNIADEPVLGYNPPTSFTTFHVHLWSCALDYRPLYLPIRSLLTVETFSVSSSVALDKSSSTLRIILDEAALHLSDKCNTVTINLSRDYVRVMDMGLLELTITAVKSDSDGEQTEPRFELHCSSDVVHIRTCSDSCAALMNLIQYIASYGDLQTPNKADMKPGAFQRRSKVDSSGRSSSRGPVLPEADQQMLRDLMSDAMEEIDMQQGTSSVKPQANGVLDEKSQIQEPCCSDLFLFPDESGNVSQESGPTYASFSHHFISDAMTGVPTENDDFCILFAPKAAMQEKEEEPVIKIMVDDAIVIRDNYFSLPVNKTDTSKAPLHFPIPVIRYVVKEVSLVWHLYGGKDFGIVPPTSPAKSYISPHSSPSHTPTRHGRNTVCGGKGRNHDFLMEIQLSKVKFQHEVYPPCKPDCDSSLSEHPVSRQVFIVQDLEIRDRLATSQMNKFLYLYCSKEMPRKAHSNMLTVKALHVCPESGRSPQECCLRVSLMPLRLNIDQDALFFLKDFFTSLSAEVELQMTPDPEVKKSPGADVTCSLPRHLSTSKEPNLVISFSGPKQPSQNDSANSVEVVNGMEEKNFSAEEASFRDQPVFFREFRFTSEVPIRLDYHGKHVSMDQGTLAGILIGLAQLNCSELKLKRLSYRHGLLGVDKLFSYAITEWLNDIKKNQLPGILGGVGPMHSLVQLVQGLKDLVWLPIEQYRKDGRIVRGFQRGAASFGTSTAMAALELTNRMVQTIQAAAETAYDMVSPGTLSIEPKKTKRFPHHRLAHQPVDLREGVAKAYSVVKEGITDTAQTIYETAAREHESRGVTGAVGEVLRQIPPAVVKPLIVATEATSNVLGGMRNQIRPDVRQDESQKWRHGDD
The following text describes a protein:
Function:
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Sequence:
MERIASFCIDHLKLERGIYVSRKDYVGNEVLTSFDIRMKLPYREPVLGSPETHTIEHLAATWLRNNPEWKDKIIYWGPMGCMTGNYLILAGDYTSKDIAPLITELFEYIANFEGDIPGASALECGNFYNNNLPFAKYEAKKYLEETLYHLTDKNLNYPK
The following text describes a protein:
Function:
Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow. Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MHLLGLSLLLLVPEYLAFADSASWTVNHPKTLYAWNGTCIWIPCSYKIPGTGHTLENLTVYHNFEYDKRTRDYTGTVLYKNQKAKEFPSRQERVQFLGNDRNNCTLLISPVNVNDTGKLGLRMTSVDNNKWLEAISLNVSERAPPPLIQLPSEIQELQEVTASCFLNFSCSGYKIHLQWSLEGHANTLTFLNVESVSTESRLTFRAQWIHHGKNLTCQLWDPTQQQVLSEETVGLDVKHTPKLEVQVSPREATIREGESVTMTCQVISSHPEYWHVWWLKDGTLLSRERTFSLTLPRVTRQMSGKYQCQAQNAIGSGISEGVDLKVHYAPESSRVQIFPSPAKEGDKVQLICLSQANPLPTNYTWYYNGLEVPGRTNENFEIPKVLIRHAGRYSCLAENSLGPGRVGEEAELVVQYPPQEVITVIQNSAPIREGDSVSLYCTYNSSNPRVTHYSWNIVGFRDHLQPAWLMIQKVAWNRAIQCSACNKWCSWSPSVNLDVHYAPKDVRVLISPPTEIHSGYRVLLQCDFSSSRPTDVHFFWKKNGIPLKEGRDLRFEAITPEDAGSYHCLVNNSIGQTTSQAWELRVLYAPRGLHVSISPKDGVVEGKTAVLSCEGDANPPIFQYTWFDWNNQDIHHYHQTLKLDPVTVQHSGAYWCQGVNQLGRNHSPPSTLTVHYSAATISRRAAMGVGFFLAILLLAIWGVKLRQTWKRIRSQQGFQENSNGQSFFVRNIKARRTPQAEGPHSLGCYNPVMEDTISYATLHFPLSETNAQRPGGARNPEARGLSPNRDDTVTYSVVQRRQVGDYENVTPEVLEDEGIHYSELIHFGVGERPVTPEGVDYVTLKH
The following text describes a protein:
Function:
Binds both host hemin and hemoglobin with affinity in the nanomolar range and presumably directs it to membrane transporters.
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor. Secreted.
Sequence:
MKKVLVFAAFIVLFSFSFLSTGLTAQAALKDGTYSVDYTVIQGDSDSASMANDYFDKPATVTVNGGKSTVSLQVNHSKWITGLWVEGNAVSVTSKNASSDTRKVSFPVSTLSNPVNAKIKVDIDDDDLNYHHEYQIKLRFDEGSAKALAGAVKSSDNNTTTPATKSDSSNKVTNPKSSDSSQMFLYGIIFVATGAGLILLKRRAIFK
The following text describes a protein:
Function:
Binds to all microtubule populations.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSSEFQGPGFYSDKNSSRVLQPPGGASSNIFGAASDAQGTPPQKANRMTSGSNIFGAAETESPSRKVNTRMQSDIFGTTGSAPPSQQQARSNRMKSDIFGGAAPAQEPARSRKDHMGSDIFKEPGPSDQVMPRKLKGKEDDLYADPQTSPASGDAYKYDGGKAAPDHYLDQDRAGRGDAWAHDEVSYHDTNPSHYDTAVMHDAPITTPGGENIFDVRYGYTPQKPGRRIAQGAQPNMAATFLNLFGTDHPDGPDGHPPPTAQPPAPTNMPAEALGYKPAPARPAVPGHQRAAAGVVSGARDARGPSAVFPEEQAASSDWRPSAKYKLRYQAALVNPITGETYASPDFDLSAPTANNLPAPTTNGTANGCGEDGNPMDGQTPAERPSTKVMQPPGGGSSFTLG
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MQNQAPVAHPVLSASILFDIVVFAGGKAPGLNPLCDNEPKPMLCICNRPMIWYCLSPWIKAGCSTFFVCVNEDYAALQSYLCREFPKVAFVFVLVPLTQNQTPTTTCDVVRGYLKHKESLKSDRLSKPRDALLLSCDTFLPGVDVEHFIHNFYASVASVSVLLFRPISSSNGNSCGTQLGPTARGNSASTPAGSGKGNKGSQGSGACAAKPYTHHFTCVAYEEKSGDHVRNDNNNNGSALCPVASGVTENSNKGSNCVSHHRLHFICPREDEPEPCISFGFAARRPNLTFAADVVDVHAYLVRNWVLHYMAESTGEGMTVQRDCIPFLARSQHSTVNVDQGVLLRPDNKLKYTIPNHWLFDESSPVPLLNGRRGPVLPVEADNLLVCCTIYEEDAAMPMRAFRAKTRKDFVALNHDILLSKCEVLGLAEGTGDLRSTKQQHQAERHHHQKQTASNHNCETAVEMFPSLPASALALCNLLPDSPITVVVKNESSRVHIKCSFLRSAPAGSAFITSSIVGSNVILGSNVRITNSIILDNAEIGANSTITGSVIGSSAMLNPGIRVVNCVVGPQCLVESDKKDSVIRV
The following text describes a protein:
Function:
Non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. The channel pore can dilate to provide permeability to larger cations. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Lysosome.
Sequence:
MKAHPKEMVPLMGKRTTAPGGNPAVLTEKRPADLTPTKKSAHFFLEIEGFEPNPTVTKTSPPIFSKPMDSNIRQCLSGNCDDMDSPQSPQDDVTETPSNPNSPSANLAKEEQRQKKKRLKKCIFAAVSEGCVRELRELLQDLQELCRRRRGLDASDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILGREIKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNIDNRHEVLTLEPLHTLLHMKWKKFAKYMFFLSFCFYFSYNITLTLVSYYRPREGEALPHPLALTHKMSWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVIFGQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFKLTIGLGGLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETAENVSKESERIWRLQRARTTLEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIRRTADSNKIQDSSRSNSKTTLYAFDELDEFPETSV