lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MRFQWFLSASASLSLFLLLDFVVWIHGERDFNVNDSQVPVIEPKDVPAYKQDPYVTELMSCQNTPSEIVLSLLLKKHDWSELTATKRAHVQAKLAKFFAIPKEFISLDSVSKRELRSMHKLAMRKGGKGNKNIETLNRRLGRASFMIGCGPSYFVMGEPIAKQIAHQMKDGTIGALTEENFGLWFIWRKELKSRSNRKRRQSEGSGADEDDYDYGDDDEEVAEPSTEVPPVTTHAHRHHHGALEVSEKIVSPESVSSSAVPLVPDVEEEIEESVSKLESVISKTIENTKNIKELPVLGEADDGEDEEEVELQQLGVPLAAEIVPDETTSAAATRATEMVKPVDLDEQEISVDSGAVPAIDVEASATPTPSMSARETQKPFSPYDATSSVSSSFSPVASIASGSEAGEDSTSVSTPHLSPANSPTVMPTELDRNGLATTSSSSSSSASPPPSSSVPTQATQPTTSASSFSSSSSTTTTSTTATVSTTTTASSTATTTTTTTTLSESPKEGGEPDAISSGNNSLANNELSTPATPTSSVATTTASTPESSSISSNFVSTDYMEPQPEENSPPIIKTRLQKLAVTSGKAFTFHVLPETFYDAEDQGNLRLALTDKDGHELKANSWLQFNADKRELYGLPLDDTVSRWQYRLSATDSGNASVTETVEISVQQHRAVRTINHEISVFVRINEKPGHNIDWQLKLINAVARTLDDSTNSAVVVREIRQTPHDPHSATFVYFNETLPTSECPEKELKDIIARLDANRLSDLVQPQLGIKSITGQLIGSCQKDLTQVKPTQHMTKNVPPMPRNQVDRVNASLGQLLVYKVPADTFYDANDNQLTLTLKTRDHLELSPRHWLQFDSKNEEFYGIPKSGDIGSEEYLLVAEDSGGLSAHDALVVVVSPAPKRDFGFFFKAYLSIKHERFNADLQRKFVERVAKLNGDPTTGQIQIRSITTHHDSDGTIVNFYNTTLYRKHNSCREKEVAMTRSVYLNSDLSLREAAKRALGPELNLTNFSVVPFSICHHTENIDTNQLDYIPSRPEEPTHKSSFGEDYMITFVWPIVIIVAMLVAASIIACCLHWCRQRSGKMELGDEEERKSFRAKGIPVIFQDEYEEKPEIGNKSPVILKDEKPPLLPPSYNTSNMNGDNDVDDYVPPPSVVVGGREVRGKSPATPSYRKPPPYVSP
The following text describes a protein:
Function:
Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, and hind limb paralysis (By similarity). It also induces potent blockade of neuromuscular transmission in young chicken biventer cervicis preparation and potent myotoxic effect. In mice, it induces myonecrosis, upon intramuscular or subcutaneous injections.
Subcellular Localization:
Secreted.
Sequence:
YKQCHKKGGHCFPKEVLICIPPSSDFGKMDCRWKRKCCKKRS
The following text describes a protein:
Function:
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is required to anchor melanin to the cell wall, for maintenance of cell wall integrity, and for proper cytokinesis. Chitosan offers an advantage during infection as it is less readily detected than chitin by host immunosurveillance mechanisms.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRLSVSAATIGAVVLAAPLVSAAGRHERGLVDPSEHPAGHLFHKRASEHHGITKRQLSTTSKNGMPYPPAGADPPPASSLPQAWIDRYNQKKNAGLIPNIPRSITDPNTRATVYPAGTDMTNVCSWTVQKCDTGDIWLAPDNYVSITFDDGPTPQSHSLIDYLQAQKQTATHFLIGSAIVWNPDAMDLYVKADPPMHLGVHTWSHTLQTGKTDLEILGDLGWTMQIIYDLTGSVPMYWRPPEGDVDARVRAIATEVLGLQTVMWNKDADDWCLRQGTGTAQLQTCTTGVGATKQGVIREMTSWAQTTNRTGFISLEHETTDQAIDAFKEYHQALVQNNWIAGAVPELQGLPYYQNQWNLTSRKERVDSILPTRDPIKVVHSDAPRGSRRAPDTSAFANLDGSGASAGASSSASAAATRTRGSSAASAATGSSSSSISSGSTSSTTNSSSKSQSSSGATHSIAGASTIGFGALAVAFALLL
The following text describes a protein:
Function:
Mitochondrial metal transporter involved in mitochondrial iron accumulation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLRAQLRPRLRGVVPTRFLRTGPVVLNEHKHGPNDKHEHQHGGKEGHKHDHSHGKSGHCHEGHDHSLMGMLKGHSHNHSAQQNPIVSEPNGWKNPAVRITWIGLFSNVGMAGAKGVGGIVFNSQALLADAVHAVGDMVADFLTLATVSMASKDPTRRYPRGYGKVEAMGAVGVSSILILAGIGMAVNGFDAILSTFDLHLPNFMGQFGHSHSHGHVDTSAVTDVADKAAAPVADINAAWLAVASIGIKEWLYRATMKVAIEKRSSVLEANAWHHRLDSLTSVVAAVTIAAGHFFNAAWLDPLGGLLVSYAIIKAGISTGKESVYQLMDRSLALDDETYEMVRDKAEDFLRSKGLDYRVENLQVLPSGPNLSAYLDVIVQKNTLTLPQANQIGREVEEDLMREIVGMKCVDVHIREEGEKLRGII
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MVDPTGKGSEIEVEDSNSNPNAPSSGNSPSSNNEQKKTCADCGTTKTPLWRGGPAGPKVSSPSISQIAPRGVKPTLDLTLCYPFFQSLCNACGIRSRKKKRAILGINKGSNEDGRKGKRTGGALGKEVLLHRSHWKKLGEEEKAAVLLMSLSYGSVYA
The following text describes a protein:
Function:
This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion membrane.
Sequence:
MNPLISAASLIAVGLAVGLASIGPGVCQGTAAGQAVEGFPPSNSLFFEKRTYGKGRFTDEELAY
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
Subcellular Localization:
Nucleus speckle.
Sequence:
MPSVEASQIETNGNGEQNIEEEPSKPVIGIIYPPPEVRNIVDKTASFVARNGLEFETRIRHNEANNPKFNFLNSNDPYHAYYQHKLINFREGNSTTEPPKQQQSIQSQITETFIPKDPPPAPQFIAEPPSISAFDLDLVKLTALFVARNGRQFLTNLMSREHNNYQFDFLKPQHSLFQYFTKLVEQYTNVLIPPKDIVQKLKEDCRDSSNILDRVKYAVNWGKYKEEQRQKEEAEQDRERIAFAQVDWHDFVVVETVPFKDDEKDNLPPPVTPEELGIRIIAQQRYEEEQRTTEVEMEVDEDDQESSPPPLPPTEADNASMPPPLPPVANAVVKKDYDPKSSKKLSESTTQYLISPLTGEKVPVDKMDEHMKYGLLDPEWRSDRDRSMKERMEQLAVYAVGGDIGDHLKNLASRRTDIFGAADEETIIGKKIGEDEIAKAKDQKAIWDGHSGSMGSVTRAARANITTEDVEMAEKRAAGITREGEDNIGPTVTSKTTELSHLSNPTPTSSTNTLPRPPMSMPSLPRSLPPPPPPQSFAPGITPMQSNNTMRPTSLPFSHPPPPGVPSHANPGNMPRVPMPPRHGFMLAPQPPPPGQGGFAPRPPSGMLRPRAEPTREPDKAEPLQKKLKADTDTGLTPEAEFLARNPPFVTFKVQVPSLPEKNEWKLNGQMISFNLPLKDQISTIKTKIHESTGLPSGKQKLQIGTIFIKDSFSLAYYNVTPATVIQLQLKERGGRKK
The following text describes a protein:
Function:
Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
Sequence:
MIKRIVVTEKALRLAEKENKITLIVDRGATKKQIAEEVERLYNVKVEKVNTLITPRGEKKAYVKLTKEHNAMDLLSKLGVL
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein.
Sequence:
MKKESTSKRLYLEVNTPMKSVFRGFVDAVSIPLEDGMIGILPGHVNTLARVMPGIIKARSGDKEIILVVSEGFMEITKDKIYIVAEDGELGERLNEDVLKKEEIELKNKLNQAQNYKEREELHKALLLNSLKQKAVKLYTTYSTK
The following text describes a protein:
Function:
Role in pharynx function or development.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized on the muscle cell plasma membrane.
Sequence:
MRRVILPLVMTVTLCLAQEASEACTKALTDCENDLECQNRLAPLMAACSTNTCQPQCRSAVLNVYQNKLGRILLRSDATCIPGRDELRTCNFLPAESTVHCSLGKLACEGDLQCNSKFGVFMSECEADAARGACTDKCKTLLNQTIETSVGSVFSNCTCTARDDQLCTNLKDNLLGVCLKNTPGVTLSPSDNSITDAPGGNDLADSSVGHGFNILSAISVYLLTVLVF
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MSNESGTNKSHPSAKAPQKTVLNLGNLPPKPKANELRQNANQYPRTPSRVNPNQPPWPAYRGYHEYSFAHATMGVRLPTILGKAIDDVWKSVNQEYDEDRIVDLVNCIGRMEHLMGDLQGNSKLRPIIDDGAGDIALWNKEIAKFFRGKDFMNAPWLFAEAYKYRRLRECFSLSKYFVEYDVFFRQKCDTFSRSNQAVFELSQRFSESQTIDANLSEEEQLEKKKLLFLELTQVCLWGNSTDLSLLIDMTEDDIKKLQSTGGDHLAATEKNILGNDLHKLANYVATLKGGRIDFVLDNAGFELYCDMVYADWLIQSGICSQVIFHGKKIPWFVSDVTKKDWDWILNSCVYGHLFEEATDVEMDSLRTLGHRWKKYEKEGKWKYEAHPFWCTGYTFWDLHSEAPDLFQYLSESDLVIFKGDLNHRKLTYDCHAPLDTPFSIAIGPLASEAGSPPVCSLRTIKSDVVVGIPTGVGEKLDEEEPGWKISGKYAVVLLSEGRKGETPVYSS
The following text describes a protein:
Function:
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MENSSSSEGRDPSAFLGEIIGAPVTVKLNSGVVYKGELQSVDGYMNIALERSEEFVDGKLKRSYGDAFIRGNNVLYISAQ
The following text describes a protein:
Function:
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MANFMTDSHRQFLQVLMSNGIIDAPEARRVHRLFCEQHKVYYAHEKLDEFVGVINTHLHPLFMEIRKGRSEDNGKMFYALVNLAITEATKLASDYAENELELFKKTMDLIVESESGYVSSTSILNLSDKLQSKKMKKKEVEQVLQMFVQDKWLSEKQGDYTLHTRCIMELDQYICEMYQDAKKCNICHSLAIQGQSCENCGIKMHLPCVAKYFESQPEPHCPHCNEVWPHETRDLVQPDSQLPSSTPRTTRRVSRSETK
The following text describes a protein:
Function:
Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSNATNNTLGSLLPQLEAAANSNSLYGGMVPNLRFNITMIVIWGILLTIHVVQLLMRQYWFSIAFICTGILEVLGFIGRTWSHSNVADMDAFLLNMICLTIAPVFTMGGIYYQLAKLIEVYGHRFSLLPSPMAYSFIFICSDIVSLVVQAVGGGLCGVAVTDGTSTTTGNHVFIAGLAIQVASMAIFLMLWFHFLFRIYISVRWEHINSRPISLSLLKISQTEVDYLYREKFHFLRLEPKRWVFHYFNLAITVAVLTIFTRCCYRLAELVVGWDGYLITHEWYFIILDALMMAIATVTLTIFHPGFAFKGRSTSIPITPGHVDPETLPHTDDVEDILDTSDSKQFDIEKEEFQASMKYPISTFKQFMSKIANLFSSKKKAKL
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Cytoplasm. Midbody. Note=Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3.
Sequence:
MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNPEKIKEAADVIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEVSRMREVAAVLLHFKGYSHCIDVYIKQCQEGAYLRNDIFEDAAILCQRVNKQVGDIFSNPEAVLAKLIQNVFEVKLQSFVKDQLEECRKSDAEQYLKSLYDLYTRTTSLSSKLMEFNLGTDKQTFLSKLIKSIFVSYLENYIEVEIGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIRQRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTILVEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLISSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDENNVLIQYTNACVKVCAYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLTYEHLQQYSYSCMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLANLDKNILHSFVQLRADYRSARLARHFS
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKCKVEKSKISGQIVCPSNKSYTHRAIFLASLAGNGSKVENVLLSADTMATVEACKKFGASIEIENSSIIVKNPIKFDKIVPEINTENSGTTIRIASGIASLFSEEITLTGDESLQKRPMQPLLDALSSIGAQCQSTDGKPPIKITGKISGGDVTIPGNFSSQFISALLISAPLTEKGINLSIKDNLVSKPYLDATIATMRKFGVSVQTLIPYKRYNISPQVYNAATFTVPIDFSSLALLLSAAVLNGDETVIKGNIGNLPQGDEVFIDILEQLGVTVNIGEDEIKIKSPEKLKGGRFDLSNSPDLLPPLTILALNSENPIEIVNVKHARLKETDRIAITSRELVKLGIKVQENEDGLILESTENLTGAELNSENDHRLFMAFCIAGMYVGNCVVTDPESVQVSYPDFVEEMNRIGARIQPE
The following text describes a protein:
Function:
Actin-binding protein required for multicellular morphogenesis. Substrate of pkgB and/or pkbA.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Sequence:
MSLTLKIQIVRDKQVKAMKFSPTQTVAEVCAQVREKINETSGDDHGLFQPGIDAKRPSRWLKMDKTLQFYDLKINDELDYKKKHRPLKVRLMDETVKTMLVDDSLTAGEILEIIGKRIGIKNYEEFSLQTEGAAAGEWINHAQPLHEQGVPDDAVVLLKKKFFVDDFNVNRDDPIQLHLVYVQSRDAIISGSHPCSYEEAVQFGALQCQIQLGNHNPNLHKPGYLKIKEYFPPSFHKKKDAEKDIYKEFRKLTGMSESNSKFRYVQLCRSLKTYGITFFLTKERVKGQKKPVPKLLGITRDSILRLDAETKEVEHEYPLNHLRRWAASPQSFTLDFGDYEDDYVSVITTEGEAISQLLSGYIEILMKKRKDTGTVIDENETDIANVESVGRIRGQTSQATTSSSLSGYDGNGGREGQYSAPGQAIGYRGGLGGPLSIKVTNIDSASAAVANLLNEMELDPNAVIGQKSSLTPQQWRQQLAIHAKAVAAAAGKLLGNLNNPNGMDKNQMDSNARDVALTIDQLVHAARAASIASGEDPDGEMPLFDGAKAVAESISKLLKATKDLSSNPNDENARNLIAQAADQLKLMTSYLDGACNGVITDSGTLRLLMEAGKAIAIATQDLVNQANVAIQDINDPIRKNQLNMAIDETMKAGIHASAVSQALAATILDPNCRQQFNTAAKTAQDTNNYLLSAAKAAQMDPALLEKLRASAKSIAEAYASLIQSADLAQPKSGDDVEFTSASKTILSAAAQLLGSQGKSDNIMQQAKVIEEAMGHLIAGARRAALKTDDPGVRDRLIQCSKAVAEAVRNLMEIAQDSADNPEDKVLFAKLQESSKRVATAVKQLVGDAGKESAFQLLRTNAKLACAATTGLMNTSRQSMLQGHLSDQESNKLLLACVQAGPAITNLLNSITSSQKAPNDLPAQNQLIEVARVSAPIAYQVVAVAKGAIPHFTDQHSKQEVSNSSNTASDAIRALLDAIGDLTSAVGQQEFDDALDTVQALEADMESSTMLVQAGTTHQIPGQTRENALELLNVAARALGSSAKQVLLQYKTSPEKLGETSKDLATSVSQVTNAAKSVCFTTQNRSVQKAVLGAAKQITTESTNLVSCARAVSSNPGDPSLESALQSSVKAIAEALANLLTTSKGGDPGGKDLDDAIEAIKNDTKRINNPPVNLGGEGGVNSEKAISSSKALVGAVSQVAANARSNPSALGASARTTSTTFTLLVDTINLCTGTIVNKQLAIEIVKGGQLLGIETIKLLQASRFAASRPGEGEGELNQTQQSVSNTVKQLIYNIQSSVPGQAEIADALEIVKQAIIALNSSESSGSRPNALESLTQAAKNLADYTAQVVQSKGNSEKMGTQCKSASESLKDVVEYTKASLSTAEGHPDSIKTLASKVDDSSNALFNSCKKTGQLSDQDKKNAALDAKNLALSVPNLMGAAKKISASLVQSNPEKSKDILLVAQNITIATSKLVNIAKSVASGQSQADVSQLAATKKEVSELISKLLNATNGHDQDATTISIDLDSLSKSEQALLDASRSTANYMSQFMAIGKTISTGTKDPNVHQQFSGAAQNVSSGVQQLLSAINGMKPEQKDLDESIEIIQNAVVDLDSATLNAAIGLLENTAPVGKTAQVCQEELVDISRELATSMKTFLAAPKQDPTNLGQSAKDTANILPKIVNISKQLASLTTNPDIKQTQLLLSKKLADNMLELMISAKSGDVSDSKQAFNASQSIADILTSVKGGVMQSRDCDESIQIIGKSKENLQKPANDTHGKTYQQYRDEMTEIAKQLALGVSQLANSAKSKPEEIGSSSLKIASIIPRLAETARSTAAATNDVAAKKKLIDSTTGIIDATSNIISDAKLASADHKNTQLQQKISNNFKDITTQIANLIAALRAGATADRDIENACNEVNHVTTDLDAASLFAAAGQIDIDTDGHTTQNIQEQVGKLAQDLKDSKNQLAEASGKTIEDVGTSAKATASINQKLAHATKVCAALTSDSTTQQNLLSAARTVSSNLQQTISASKNAQKNPNAGNKAILDKSSQELEESIDSLANLVQSSTTTKGISELEGVSSEIRKQLAAYDSATANVNANATAEDVVNSAKNLAESIAYLVSSCNNSPEDIAEASKGTTLAIKSLLANAKGASVLTDDAVIQQNVTESAKAAAQTVLKLIQAAKQQRNDPSNPAHQNKLSEISSEVVESISTCVNAAEDLPEGKRAKLLFAAGESLEETAEKELKAAAAIIEEATAALLNAKKKREQNRIASGIDEAGIDESILEAARAITSATGVLVQCATNVQHELVLAGKVGNKGNMYRRDPTWARGLISAAQAVAGSVQGLVHSANSSSQGKVDEEQLVASAKGVAAATARLVTASRAKADLNSASNSQLAQAAKQVSNATAALVEAAKQVNEEPEVEFDTTNLSNAQIISKEMDQQIQILKLKKELEQAEKKLFSIRKKEYSDQTGNPSPAKDSDNKPTTSISVGITPTKRTTQASPPSPPLTPTQQAAGTPTLPPRPLMKKPAPSQAPSSPVAPVSAPVSKPSPKPAPKPAAPTAAAPNKTYTLEELKKKPANIDHSNLEIYLSDEEFKAVFNCERSELAAMPTWKRNNIKTKLGLF
The following text describes a protein:
Function:
Inositol polyphosphate sensor that associates with transcription factors to regulate Pi starvation responses. The SPX domain provides a basic binding surface for inositol polyphosphate signaling molecules. Interacts with PHR2 to inhibit its translocation to the nucleus and repress its DNA-binding activity, and then negatively regulate Pi signaling.
Subcellular Localization:
Membrane. Nucleus. Cytoplasm. Note=Unlike PubMed:19566645, PubMed:24692424 cannot find a membrane localization.
Sequence:
MKFGKDFRSHLEETLPAWRDKYLAYKSLKKLIKNLPPDGDPPPVAAAAEVPAGDGDGDGGIALGNWFARVLDMELQKLNDFYIEREEWYVIRLQVLKERIERVKAKKNGAFTSKSEFTEEMLEIRKAFVIIHGEMILLQTYSSLNFAGLVKILKKYDKRTGGLLSLPFTQRARHQPFFTTEPLTRLVRECEANLELLFPIEAEVLESASSSAKLQPQNDDAASHDPASSVDVETSDVYRSTLAAMKAIQGLRKASSTYNPLSLARFFHGEDGEACSGAITSESDSYSDSQIEDAEDDDKEVQSREQNTAQNAAEGQPRDE
The following text describes a protein:
Function:
Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts. The DNA is bent, the damaged base is rotated out of the DNA duplex into a hydrophobic binding pocket (nucleotide flipping), with Arg-39 donating a hydrogen bond to the orphaned cytosine to stabilize the extrahelical DNA conformation. This structural change in DNA presents the lesion to the nucleotide excision repair (NER) pathway. The affinity for O(6)-alkylguanine adducts increases with the size of the alkyl group. Low affinity small O(6)-alkylguanines are directed to the global genome repair pathway of NER via rhp7-rhp16 and rhp41-rhp23, while strong binding to bulky O(6)-alkylguanines stalls the transcription machinery and diverts the damage to the transcription-coupled repair pathway of NER via rhp26.
Miscellaneous:
MISCELLANEOUS: Does not have alkyltransferase activity. A tryptophan residue replaces the cysteine at the known active site of MGMT.
Sequence:
MRMDEFYTKVYDAVCEIPYGKVSTYGEIARYVGMPSYARQVGQAMKHLHPETHVPWHRVINSRGTISKRDISAGEQRQKDRLEEEGVEIYQTSLGEYKLNLPEYMWKP
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion. Mitochondrion matrix.
Sequence:
MSKKIVNPPRLQGLSRLRVRPKREKNTIPCGQEMAALLGCWQNHGGQTDTAQCANLVAALENCMKTTHRKTKSENTINYHLARLGKLL
The following text describes a protein:
Function:
Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity).
Sequence:
MEPIGARLSLEAPGPAPFREAPPAEELPAPVVPCVQGGGDGGGASETPSPDAQLGDRPLSPKEEAAPQEQEELLECRRRCRARSFSLPADPILQAAKFLQQQQQQAVALGGEGAEDAQLGPGGCCAKCKKRVQFADTLGLSLASVKHFSEAEEPQVPPAVLSRLRSFPMRAEDLEQLGGLLAAAAVAAPLSAPPSRLRPLFQLPGPSAAAERLQRQRVCLERVQCSTASGAEVKGSGRVLSCPGPRAVTVRYTFTEWRSFLDVPAELQPEPLEPQQPEAPSGASEPGSGDAKKEPGAECFHFSLCLPPGLQPEDEEDADERGVAVHFAVCYRCAQGEYWDNNAGANYTLRYARPADAL
The following text describes a protein:
Function:
Involved in spliceosome assembly; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.
Subcellular Localization:
Nucleus speckle. Nucleus, Cajal body.
Sequence:
MAAEAAVLWKQGWHLSAEGIAALKQENNITTIDGIVRKALDEDLRSIGEKFLPEDISRGGSSELIGPCVLQVTKVRNVSAPKANEESGHAPRMLKVQMTDGHTTCIGLEVAQVQQLSLSTPPGTKVKLTGSIAISNGFLMLEGSNVKVLGGQVEKLFSRWDIQRKLAHHSRANVKVEGGAPPFVPFGQRVSGGAVATKDLRNKKSLPKKETESEEADEFSEQRKAVIAEVSKSKEGTKTFGGTGSLPATAVPEKKWGGPADRRGENRPQGVYRELSNESSQVEEKSVQKLVEMGFSRQDSVASLRQNSGDVQEAINTLVTRQGQGQGQGRDRPDRGHRGQREDRGRGENCHSECVMCHCHTGDRQGTGDRGRTGAEVRTVTQNVSCVIVILILVTGRGQGTEGGRGQSKASTVIVLFLSRRQFTTETDWIKLFLCFFTGRGRGRRGRGDEEEEDVSTRPSGPATLFDFILESKIDNLKIDDSKPSPGAQTSQPPRYNKPQGGRENHYDGQGWPQVGDSQFYGQRNNNDFRGQRNQPGGRQQYDHQNREGGQHFNDSRPYDGGRGSRGGRGRGGRHDRGGGGRGRGTGGTDSNYNRGYQEDVGRGRKGDNRQDNRQNFDEFGRQREDSRSNGPHGRHDNYRDARRGGGEQGNRPGNRDAREQQRGGKTENQEFRGQNNDSYRDHRRNEPNRQQEGGNPRRPEFRGQNEHFQENQRDGYHHRGDRNNPKQQHQDFQENQRDGYHHRGDRNNPRPQHQDRNDGRRMNNRQGSYEDRGGGQRQGADRTNQPRHGGDGGQRKWRRNDHCLARYWEDGKFYPAMVTDVAPNGRTAVVLFTEYENYEEVEMFNIRPLHGGGWMDSPDPVSTGVTPSANQKYEPYQGDINTTLEFHRSGDRRRPPQDRAQSAPTHGRGPREQPKEPKKPSRPALPIYQPPAKKKQSPE
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MDNQSIFKYSWETLPKKWVKKMERSEHGNRSDTKTDYLFQLLCFLKLHTYTRVQVSIDICGVDYPSRKRRFEVVYNLLSTRYNSRIRVQTCADEVTRISPVVSLFPSAGRWEREVWDMFGVSSINHPDLRRISTDYGFEGHPLRKDLPLSGYVEVRYDDPEKRVVSEPIEMTQEFRYFDFASPWEQRSDG
The following text describes a protein:
Function:
Plays an essential role in viral DNA replication by acting as the polymerase accessory subunit. Associates with the viral polymerase to increase its processivity and forms high-affinity direct interactions with DNA. Facilitates the origin-binding protein UL9 loading onto DNA thus increasing its ability to assemble into a functional complex capable of unwinding duplex DNA.
Subcellular Localization:
Host nucleus.
Sequence:
MTDSPGGVAPASPVEDASDASLGQPEEGAPCQVVLQGAELNGILQAFAPLRTSLLDSLLVMGDRGILIHNTIFGEQVFLPLEHSQFSRYRWRGPTAAFLSLVDQKRSLLSVFRANQYPDLRRVELAITGQAPFRTLVQRIWTTTSDGEAVELASETLMKRELTSFVVLVPQGTPDVQLRLTRPQLTKVLNATGADSATPTTFELGVNGKFSVFTTSTCVTFAAREEGVSSSTSTQVQILSNALTKAGQAAANAKTVYGENTHRTFSVVVDDCSMRAVLRRLQVGGGTLKFFLTTPVPSLCVTATGPNAVSAVFLLKPQKICLDWLGHSQGSPSAGSSASRASGSEPTDSQDSASDAVSHGDPEDLDGAARAGEAGALHACPMPSSTTRVTPTTKRGRSGGEDARADTALKKPKTGSPTAPPPADPVPLDTEDDSDAADGTAARPAAPDARSGSRYACYFRDLPTGEASPGAFSAFRGGPQTPYGFGFP
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MDNDLERSVRLLEDALQTPTKGLFKVSTATPKREKPNLSFTINPEDLTGLEYGSVYQNTLSLFVDDDKTVTGSVIQAGTPWKNTVNNLYTEFADILQGSTGGLDILDVAEDLARCCSDALAVVKSLKAKVATSELAEEKWLENERNNWRLLYVLYQDRIQAQNHSKEGFEEDFGSSEKNCVCELFKRENLVRESQLVIDWLERNALEKGDPILMHSDWTYGWEHTLHQLLAPDAIAIGSNVDIIKNIHPDAPQFQRLSLHHLDYDNDKKLCQRIFMEIRCGNLEGAQELCYNSGYPWRAAMLEGWKLFHNPNLETSLEEYKDVEGNQRRDLWKSCALDYCHRSNLNIYEKAAIGSLCGFLEGILPVCTTWEDHLWAYMRTMVDIRVESEIRDSIIKNYIPLPEEYWEQKKSLSEIFTILEASKNIDIAKEAHEIDHVIQKLVILDEIPTLIRLLDQWSEDLSVTTQSLRFYAHLVLFFESVGDSTHRKTCEKIVETYIERLSEMNETQLVAFYVSKLGKSKQIQLYAKHCEKLLSTEQRKNALTYAEDFSLDVFAITQQIVEIITSRPSESELPGNLQGKITEIDELKISAIDWLMFYEEQRAEALAQTNSIIFKFLILGKLEAAQLAINKIPYDSIEKIRSEEQIHQIVKNYLSYKAYLDAHEAFNEWFRQYRNKPMPPPELPENAQFTEKVAHNHKVSQFNAEAERWKLTTSHSAKRAKTLLYNVLLFPEGWLEGGDDAEYLRSICIPQIVLLLYSVLNESGLHEEAVQLADLVAAKKYGLYKVYSKEKLAEILEKICESSVALLNAKKDPFGSSSSV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAYCYNRDFMFCDVCGSQLLLNSPKYATCPNSLCNFKKSSKHIKRGEIHYTITAEDIRRELKIDPFVQLTTVAMGAEQPQQKKVTDTPCPMCRHPKLEYYSRQMRSADEGETVFYECPNCHHKFTENN