lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system; Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays.
Subcellular Localization:
Cell surface. Secreted.
Sequence:
MRLLWGLLWASGLLALSQQKPRLLLLAPRVVHLGAPLSVSMHLEGLAPGQRVSGTVFLRNPSDVQIPCSPETPFQMDADSDFQLLQVRVPVMQAQACGLARLRRAPRVQLMVKSPWLRENGGLTDTQGLHLLFSSRRGFLFLQTDQPVYNPGQRGTRTEMTPDPSPPPQNALGLQVRRKEMFSQKSILQDDLMIPDISEPGTWKISAHFSKAPGSNRSVEFEVKKYVLPNFEVKITPEQSHILVTPNDISDVTLEIEAKYVYGRPVQGVAYVRFGILPEGGEKSFLRGLEKQLKLEEGKCSVPLTGAELSAARDKFSTAALLDSRLYVAVSVIESPGGELEEAELTSLRFVSSPLSLDLSATKRHLVPGTAFLLQALVRDVSGSPAPGIPVRVSAQFTPRGPPAAASQLLTDAKGRVAIPINTPRDVQELNLAVSGGCRGTGGRGASLTARTPNSRGLGFLSIERRDLRDPRPGETLSLELRTVGADPTASRHFYYMVLHKGQIVSVNHVARAPVTSVSILVTEELAPAFRFVAFYTQQGLPVANSIHVNVEGSCLGLLELGLESSGNLRPSDKLRLKVRTDGKATVALSATDTAVFAVSRKAQSRARLDMDKVFEAINSYDLGCGPGGGHDTQNVFQAAGLAFNGGDYSPQLTSESLKCPKEEEEEKRRARRSAEMRKKMQDLSEAQRCCKDGMTSLLMKLKCEQRAARVRSLTCRQPFLDCCHFAVQQSKAQSYRSSHGLARGNAWEQEEELVNEDDIYLRSYFPENWMWELLDVNGVQRTPFPPQLPLRGSEGPRRPSPAGLCVAPPVQVRVFNEFHVHVSLPRSVHRFEQLELRPVLYNYLDRDLPVSVSVSPTEGLCLAGGGGREQQLTVPAHSALPVAFAAVPTAAGNLQLRVLARGPQELGVGDVVAKILRVTVSPQTGPLDPPSPPAQTRDPSPLTPGDSAPDPPPTFGEGGALSPGGLGSLMQVPQGCGEQTMILLSPTLAAARYLDRTEQWGALTPEAKDRAVDLIRQGYERILQFRKSNGSYGAWLHRDSSTWLSAFVLKVLSEAREQVGGSARGLQETAQWLLSQQQADGSFQDPCPVIHREMQGGQTGPDHSTALTAFVTVALHYSLTAFQPREPDDQDEKQKQELLRRVVGVTLGLLDSYATAISAYTLSLTQAPESDQTRAHLSLMAMAQKQEGDQGLGSKDELLGPEAALAPAFAVETTGYGLLHLLLREGTEVEAGQAARWLTKHGSFGGHFRSTQDTVVALNALAEYWIRSHSPQETRLNVTLSSLGRQGLKKHVLHLSSAHSPGREEELQFSLGNAIRVEVGGNGQGMLKVTILRQFHVLEEKNSTCLDLKMEVTVTGYVQYSRESREPGPGGGMGEAKAAPGDDPSVSGPGLGPEPPVTPLGLFEARRRRRRREAPGLGGGDGHDDPQVLYNVCIWRVGREQLSGMAIADITLLSGFHAQESDLEKLKGLSDRYVSEYETHGPHVLLYFDQVSECVAFRAVQEVPVGLVQPASAVLYDYYEPARKCSVFYSAPSQSKLLSALCAGSVCQCAEGKCPRARRPLQREEDDEDGYRMRFACYSPRVQYGFLVQVLRAESKAAFRLYEAKITQVLHYSKDHQAAANETRSFLVRSSCRLQLEPGKGYLIMGPDGLTKDRHHNPQYLLDSETWIEELPSPGLCRATRHRQSCARLHDFLEEYGSQGCQV
The following text describes a protein:
Function:
Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.
Sequence:
MSDSQIYSATYSNVPAFEFVTSEGPIMRRKKDSWINATHILKIAKFPKAKRTRILEKDVQTGIHEKVQGGYGKYQGTYVPLDLGAAIARNFGVYDVLKPIFEFQYIEGQTEVPPPAPKHNHASALNVAKRQASLLKKQKEKQVQPTLSDTSFGSSTSVPPTTVPKKRGRPKRATLSATPSLQRSDTTPINKSLIDFNANDHSAKSSFIGVVPSFARNDTEQDALQIMTNNMNLRQEDLASVETDDDEEYHNGSRGDGLQNDSFTTKRRKYPGGMTNGNGLESQADLLTSKELFGVSRTSFEKRANQQHNHYSPLQPYHQPSISLSQENQIYSDYFQSLLSYFLDDNNKIRSPIPDSLLSPPLPLSKIHIYQTIDSDGNTIFHWACSMGNLNMVEFLLKTFTHSLNPDVRNNNGETPLMFMVKFNNSFQLRNFPLILDLLKESVLLVDSNGKTVLHHIVDTDSKHKREKFAQYYLESLLEKIVDERQEQGDSNGHAMEDDLTKDELVTKFINHQDSDGNTAFHIAAHNLNKKCIKVFINYHRFINFGLRNLVSCTVEDYLASHNYVLRLDPVEHDQSNNSDGDEDIMEDYTNENQSFETQLHNSKMAINLQNTTANLLTEKMTQLAYAIDSELSEKDEVILKYFKVLSQINQIKLESQRKILSFFKLDHLIEELEQNKDDSQQQQQQVTDDDDPTSVHGNDLHLDFKRDHILQEEIYRLMNDLTYQELHQQDELDKVEHSYRMTKERLHEKVLDASSFVIDQTHQQGNVHEQLELAKQLQVEIIKRKKLVDEISKLTKNVPLPENPNAKTIIDTYPSTDKLYKYCKLISLSCGIPMDEIETSIDAMEESLVKK
The following text describes a protein:
Function:
Phytoglobin that reduces nitrite to nitric oxide (NO) under anoxic conditions (e.g. during flooding or in waterlogged soil) and upon root nodulation (By similarity). Required for general plant development and during nodulation, especially for the onset of symbiosis (By similarity). Monitors nitric oxide (NO) levels during early phase of the nitrogen-fixing symbiosis and buffers oxygen in functioning nodules. May not function as an oxygen storage or transport protein (By similarity). Has an unusually high affinity for O(2) through a hexacoordinate heme iron because of a very low dissociation constant (By similarity).
Sequence:
MGTLDTKGFTEEQEALVVKSWNAMKKNSAELGLKLFLKIFEIAPSAQKLFSFLKDSKVPLEKNTKLKPHAMSVFLMTCESAVQLRKSGKVTVRESSLKKLGANHFKYGVVDEHFEVTKFALLETIKEAVPEMWSPAMKNAWGEAYDQLVNAIKSEMKPSS
The following text describes a protein:
Function:
Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor.
Sequence:
MHKRIKNIKYAVVTVSDSRYNDLIKGKEVDDKSGKLLKKELNAKVYTIIPDNKNMIKGIVEHIVEFFDVDCIVFTGGTGIAERDVTVEALKEIIEKELDGFKIIFQKLSYEEVGFSAMLSRAMAGIYKGKIIYALPGSVNACRTALKIIKEETGHILGHLREG
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MKIPKRFRTYCPFCKTHNEVVVERVKKGQASSMTHIARQKKRQEGIGNSGKFSKVPGGDKPTKRIWLRYRCTVCKKAHQRPCFRAKKFEFKE
The following text describes a protein:
Function:
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MGLNADWMQRDLNVLWHPCTQMKDHERLPVIPIRRGEGVWLEDFEGKRYIDAVSSWWVNVFGHANPRINQRIKDQVDQLEHVILAGFSHQPVIELSERLVKITPPGLDRVFYADSGSAGIEVALKMSYHFWLNSGRPRKKRFVTLTNSYHGETIAAMSVGDVALFTETYKSLLLDTIKVPSPDCFLRPDGMCWEEHSRNMFAHMERTLAEGHDEIAAVIVEPLIQGAGGMRMYHPVYLKLLREACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIAPDFLCLSKALTGGYLPMSAVLTSETIYRGFYDDYQTLRAFLHSHTYTGNPLACAAALATLDIFEEDKVIEANRALSTHMARATAHLADHPHVAEVRQTGMVLAIEMVQDKASRTPYPWQERRGLKVFQHGLERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRDAVSVAVSDFHPDHRDPG
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGQRVSNWFNAEPRHLFDVLKYHELFCSILGINIYQYVGNPANGEARLSTVKVVNFVILNLLLVAVAAVHANIPYDLLNNGSIIVTYGIRTLLVGGMFGTCGVLMIHAWNWKSVIRVLQEIHQIDLKVTQHILLGSGLSLFLHQSILLFYNINTTKHIEDQTVSWQMIFGQIYFNIVYFSIVCLFFCMSYVMSFRFVHLNQTLKLRFDTSNGDRQGFLLGENSHRGGSVQERIRAVQKIANIYHQLTEITFQLNGQFADVLALNIVVMLMFSVFNIFALLKVYASDDSRTLMFSVFNLCGGMFYSLMFLPVVGLSQMVSKEVRRLCKAKWVWVNAMNNESNGALIRSMMLFSRQIRNRSAIIASRNIVIDWPFIFQVRLIS
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in fructose transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site.
Sequence:
MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAIKKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKIGLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLKYGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGKVDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA
The following text describes a protein:
Function:
Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals.
Miscellaneous:
MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSIVALKNAVVTLIQKAKGSGGTSELGGSESTPLLRGSNSNSSRHDNLSSSSSDIIYGRNSAQDLENSPMSVGKDNRNGDNGSDNEKANLGFFQSVDPRVISDLIIGLSDGLTVPFALTAGLSSLGDAKLVITGGFAELISGAISMGLGGYLGAKSESDYYHAEVKKEKRKFYDNSNLINREIEDILLEINPNFSDETIVSFIKDLQRTPELMVDFIIRYGRGLDEPAENRELISAVTIGGGYLLGGLVPLVPYFFVSDVGTGLIYSIIVMVVTLFWFGYVKTKLSMGSGSSTSKKVTEGVEMVVVGGVAAGAAWFFVKLLG
The following text describes a protein:
Function:
Not yet known. Might function in the uptake of a still unidentified substrate.
Subcellular Localization:
Periplasm.
Sequence:
MKMNKSLIVLCLSAGLLASAPGISLADVNYVPQNTSDAPAIPSAALQQLTWTPVDQSKTQTTQLATGGQQLNVPGISGPVAAYSVPANIGELTLTLTSEVNKQTSVFAPNVLILDQNMTPSAFFPSSYFTYQEPGVMSADRLEGVMRLTPALGQQKLYVLVFTTEKDLQQTTQLLDPAKAYAKGVGNSIPDIPDPVARHTTDGLLKLKVKTNSSSSVLVGPLFGSSAPAPVTVGNTAAPAVAAPAPAPVKKSEPMLNDTESYFNTAIKNAVAKGDVDKALKLLDEAERLGSTSARSTFISSVKGKG
The following text describes a protein:
Function:
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation; The flexible region (FR) is required for ATG7-binding; The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity).
Sequence:
MLRSTLSNWREYLTPVTHQSTFENTGQITPEEFIKAGDYLCHMFPTWRWNQQQGGMVYRDFLPQDRQFLVTRKVPSNMRAADSVNVGGEEETSAGEYWVLQPQQESADGGEEIDIDEMLQEMDIEDQSGEQDIIQLRPSHTRFYDLYITYSTSYRVPKMYLVGFNNDGTPLTPQQMFQDIAPDYRTKTATIEKLPFFKSAVVAVSIHPCRHANVMRVLMEKVRAAKQKPVEEEQPDGPREDWEDLQDEVDSSLRVDQYLVVFLKFITSVTPGIEHDYTMEGW
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MGEFELIRRFFAAAACAAPAADVALGIGDDCALLAPPAGEQLAVSTDTLVEGVHFPAGCDPFLLAQRALAVSASDLAAMGAAPLAFTLALTLPQADAEWLQGFARGLDAMARQCGLALVGGDTTRGPLSMTLTVFGRVPAGQALTRAGARPGDLLCVGGPLGEAGAALELVLERRSAPAEVAEPLLARYWTPAPQFGLGLALRGKASAALDISDGLLADCGHIARASGVALLVECQRLQASAALSGLLAGEEALRQQLAAGDDYVLVFTLPPEYLGEIRAAWPAMAVIGRVEAGQGVHLLDADGKELIPAAAGYQHFGTQRD
The following text describes a protein:
Function:
The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus membrane. Note=Shuttles between nucleus and cytoplasm.
Sequence:
METILNTQFDQLQKAIEGIKEAKSKGQSTDEARIATTLMFVALKHANREVKHKIKAGRDKLHLEKCKVDLSRLQLQNLLYEVSHLKKEIVRCQKFKSRDTSLELLSEAEYSSELPDMPNDAEELSSHKQHLHRLDCELRLRKALDKQYSALLSSKQELLQDNLSHAQRYVSFAPALRTLQSATKPLHDALQLSLDVEWKLSAVVKYLPKPLYVLFIVLQSLQRVSEEQSFTAEVVGYESEAQMQELLKEKKCSTLNYRQTKKESGDREKIADKNNLDDSLAPHPLHICLTIGAAGSNQLVLQIRYFDFIKCATVWGQLNCSRNANGQGDTNFVHHLLRHLYPNDLGNELPIPGIQYELRSSDLTAEECVRYLKAKDYGKPFCWLQSMCSIATVNSSMLYKHELNLNKNNKEIIDRIARRLNSWQRLSQQIRGLTFKDIDLYSLQENIYPAGLSCSLVQWTAITHEELHSQISDALNSSSADKGITYNSYRAVIVRGSAKMECFIRIPSNYPLEMPLWILNVHWNGCLTAQNNSAIKMMEFWTNSLQPKHLEPNDCILYAQLFRTIYSFDIFLETEGSMQNTIEYNKEKPYISAFAKRSRSRPYKYIKKGSVYAFKQ
The following text describes a protein:
Function:
Probably involved in the repair of mismatches in DNA.
Subcellular Localization:
Nucleus.
Sequence:
MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLEQQMPSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEPP
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Sequence:
MKFRVDDEVIVIAGADKGHRGKILKVDRDKDKVVVEGAARVWKHVRQSQKNPQGGRLNKEMPMSASNVMLVDPSTGKPTRIGVRYLEDGSKERFAKASGESLGQIAPAKASKAAS
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MCSIGEDDFGDEGGVHAMKEESPLPEGATTIEQEICRKCNDQRAVLKLNQKEPQCRECFLHYVRHKFRASLGATKIVRRGSKVMVVFNGAPENVVMLDMVRHGLEQEAFKKLRVDPVVVFVGEDFIGRDQEGYEQSVREKVQILRQFGFPAYYTVLGAQDSCSIEDNCLAGKFIGDQDKVTKVLQGIKSITSKQDFIVQTRKQTYKAIAKKLECGYIFLSSIGLELAKTLLSDVSLGRGKSLALDIAFCDDRDEERKIIRPMRDLNPEEIEYYLKFAENQLQSVAIVDPYLDKSSLQNLTSKFVDGLQLSFPSTVSTVFRTGDKLGAEKIPTCDNQLEDDDHFATLFDKSLKLESNAEEPRKCKFCHSALDYRDSTTLFATEFSRMVSSRINVQLSHEEIIESTKLMEQDACKLVNAELEDDEMRQLKRELCHACRNILVDFDGK
The following text describes a protein:
Function:
Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.
Subcellular Localization:
Cell membrane.
Sequence:
MNRFFYSALLYLLSPLLLAYLAFRAIKSPDYRGRWGERFGLAQLKPTDLLIHSVSMGETLAAIPLIRLIMQMHPELSITVTTTSPTGSAEVRKAFGDQVQHCYLPFDLPWCVSRFLRQLSPKWCIIMETELWPNLVELAAKRGVRLMLANARLSAKSAAQYAKRSQLSRPMLQRLDVIAVQTQAEAQRFIDLGVAADRVTVCGSLKFDLSITPDRLTLARELRQTWGKETAPVWVAGSVHPGEFDAMLSAHKRLLAKWPEALLIIAPRHPEQFAAVADVVARQGFEYVRRSDAQAITATTQVLVGDTMGELLTFYGAADQAFVGGTLIENGGHNPLEPVAMGVPVMVGPNHWDFAQITQMLADAGGLRIVSSGQELAENLIQYFKQPVLCQQAAKAGLAVVEANRGALQRQFALAELLLTRQTA
The following text describes a protein:
Function:
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Required to suppress amino acid starvation-induced autophagy. Enhances the STK11/LKB1-induced cell growth suppression activity.
Subcellular Localization:
Cytoplasm.
Sequence:
METLALVAPITSLEFFQDKFLLTGEGPVLSAYSLHQSLKAFTSLNVLQHQRIHGIRPRNQSLLSAHSSASEQGLASTPEPSFHDFAVFGGKALRVVRLHVDIQNVENMHFEILGPHLELQDWVLDARWLSGNNPSLLCVAVAHNGALLVDVAAGHALVQRFCLEGCLLYSALLLVHESWADSVLVGGTVFNQLIIWKTEKKDEHWDSGDKAPVERRLLGHTGVIFSVAYLQEEGFLASASDDRSVRLWGVGALGGPGGKCGDVNPTCLRVLYGHQARVFLVRLSPGRVFSAGEDGACLVWDWKEGGKVMRTLKGHRAGGVRALAVSQEMMDNRRWVATGGADGGVRLWKVESGQEESAEATTELTDLKFPQLGLPKIVCRVGGGENPSWSQFVVCTDRGSVCLYIDGTWETIWQGTAEFQSYCVMETVTVCMTQDSTAAVSLCAVGNISGSLEVFPTSHPRSGVRLHGGSGKIQSLHFQKEKDRVYLLASGADGLVYRWCVEIKTSESCSVVLSAWRLPPFLLPQCAKRWLTAAVRFHATLEKVLWVCGDRRGSLLLYQETTRFNGGFPTERESSVGGQSREEEESKEMLDPPLQPVSSRFGVHGKHGVTSVCEYQGLFYSTGKDGCVRIFRVHQASEEKPEESREKAAEKEERLVLDVLRVQRACKGMEWLERVLILESADCLEEEEQNEEENPKEASLTEDKSVFEEVLHEKQNVGKEARFVIAGFHAAHFVVWDPLRRERLFTVPCGGGHRSWALWLSHTGMWPGYGALVFIKQGAVLTSQPPGKLLGAKAGRTGPRDLREGVHGKGIWCVCRVGRIVGVGHVTQTKCATNNTGNEGGDHERKESFWEIIVTGGEDTSLAVLALHPPSGAVRVLSVITDHISGVRAVTAVRRPHCESESQPLSTLLVSAGGRAQIQSYRLSIGWNRQTLTPSCQVIQVGGHRLDEQWERRRNRWKTVKMDPETRYVSIAVVEESCDRVLLALACSDGAVRLFSVTESKNHIELLWETCHHQRCVLSVATCSLEAVKNDRYKLLFSAATDGKIAVWHLTGVLSTDISSGATNPPAPCLDIPAHQSGVNSLVVWVEKLGKEGGSCQVTVASGGDDGQLTVSTIRVQFPGNGKAGGSRVFSEISHCQSSVEELQIDHNQLQLHLLTQRRIPLAHAAPLTSLKLLRTGLLVSTSSDQRVCLWKVSDVGISHSGALCSHVADAAAMAVWEGEKEDAISATGSESELVNALSRKEEGQMQPETKTERTEGGWISDGEEAAGEQELGQPAVAVKETINPVCKNAVDKEEPSTHHSRLKTLTDSSGETVNGTNTKRCLKVSPESQTGIIKEGWVLVCGQGLQLLQVRSLAMDGWRENRDKSNRSIKVTLQKQPT
The following text describes a protein:
Function:
Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEPKYTGIWHCVRDTYHRERVWGFYRGLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAVLRLARGLLT
The following text describes a protein:
Function:
Participates in DNA repair and in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MASKRVLRACKLQGLSLHADALRRLTDELTNESSLQLEDVIYAIKNNIDRSKMTTSVVTLGALESALDTLLAVSAENDFEQIQVFGAFDTPRLHFNTHNNSYELKADAHRRLHAGPESRIQLLRDRFMSVDLRVKRNRLFAPPSAALANTTEYMELSRIESLLGMTGLRRVIGMLGQDERNRMYLEDFTSRIIIDLTNAVYTDGLFTINCVVLVEGEVIDDVLHVQSMGFPPPETKETSLEVLGGIDPLGVEVSAQQREQIRTLEASDHHATFIVLSDVHLDDPQVMSKLDELFQGLDSVQPTLFILMGDFMSTSIGGGAGSNSLQDLREYLEDLGNLILKYPGIAENSRFVLVPGPNDPGSSRAFPRHPLPDLCTRELVRKVPNVMCSTNPCRIRYYTQDIVIFRDDLQQKMQRHAILPPMPSEHEEAAMDESDEAGQSVSQTDISKHLAKTLIDQAHLCPLPLMANPINWDFDSSLQLFPTPDVLILGDSTEQYQLGYSSVGVFHPGPFHADFSFVFYRPSTNTTEFSRVE
The following text describes a protein:
Function:
Acetylates the N-terminal alanine of ribosomal protein bS18.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEIKRIQQQPDLAQDIYAVMAAVYPVSPWTLEQIQADLSQDQTWYALAYDGAEVIGFLTVQETLFEAEVLQIAVKGAYQGQGIASALFAQLPTDKEIFLEVRQSNQRAQAFYKKEKMAVIAERKAYYHDPVEDAIIMKREIDEG
The following text describes a protein:
Function:
Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).
Subcellular Localization:
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein.
Sequence:
MSMYGFDASFYDYGFSDPAITRSFYGNPIDFDDDLYFRRRPPVIRQTPPTETLPEQKRHDGTSPLPLGMDWSLPPRLWEGRNTVWPHDSHKKWSYCVTVPSWTIEADGSDTVFFKVQVGIQSPEGITSTRQVPRRFNEFLKLYSELKKEFPKKNLPPAPPKRLTKMRSKTLLEERRCALEVWMEKLLSDVNVSRTVFVAIFLELEAAARQSCSELNLDGSAATSVPSDQFLSNATSLIGSSSSVTSDLENRCADETSEDQNHGEPNMVRERSSDMQWDWEELTRKCMELELRLTIEQDARAYAESFAATIIQQNEMLRKELDDVKKQVKSLETSHSELEQELNKRLKDKVELENEKQEGRLETLIKETVEACTTMTDETTIS
The following text describes a protein:
Function:
Its overexpression in smooth muscle cell lines increases their migratory ability and inhibits collagen type I expression. May act as a negative regulator of collagen matrix deposition.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MHPQGRAASPQLLLGLFLVLLLLLQLSAPSSASENPKVKQKALIRQREVVDLYNGMCLQGPAGVPGRDGSPGANGIPGTPGIPGRDGFKGEKGECLRESFEESWTPNYKQCSWSSLNYGIDLGKIAECTFTKMRSNSALRVLFSGSLRLKCRNACCQRWYFTFNGAECSGPLPIEAIIYLDQGSPELNSTINIHRTSSVEGLCEGIGAGLVDVAIWVGTCSDYPKGDASTGWNSVSRIIIEELPK
The following text describes a protein:
Function:
Component of the NF-Y/HAP transcription factor complex. The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters. Plays a role in the regulation of the embryogenesis. Involved in the abscisic acid (ABA) signaling pathway.
Subcellular Localization:
Nucleus.
Sequence:
MERGGFHGYRKLSVNNTTPSPPGLAANFLMAEGSMRPPEFNQPNKTSNGGEEECTVREQDRFMPIANVIRIMRRILPAHAKISDDSKETIQECVSEYISFITGEANERCQREQRKTITAEDVLWAMSKLGFDDYIEPLTLYLHRYRELEGERGVSCSAGSVSMTNGLVVKRPNGTMTEYGAYGPVPGIHMAQYHYRHQNGFVFSGNEPNSKMSGSSSGASGARVEVFPTQQHKY
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYEQIFKPLDTISKIFGTYQSKVRIFQCLISTTGIVLLSLYYFFYKLTEIVSTAYSLVVLRYFSHLIALVLIVIINLFQFGDVQNVLTNLELVDLELIRLGQNRGLIKINKSHKNWARILTFVFNVGANICGLTFSVLLRKHPEIIHLIVLGYPRIVLCNFSTTFFVLSMMIQDRFTIINTVLKKKNNFDSSIITRLVQAHSNLIKIIDKVNTIFNPVIIFFFAIDFILIVGDLYIISSTILFTITSNNKFMASLIKNCLFYTTELIYFTIRSAKLCREANRTVKILTALPVPFSDEKKRNLIIFPVMRLLQNRIKITAFGFFSLDYELLFSMCGTACSYLFIMLQINTENLEQKSL
The following text describes a protein:
Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Subcellular Localization:
Secreted.
Sequence:
MPRVLSLCALVLSVVLVAVLSGTAAQGSSGPMCGRLLVRRFQRLCMDLRRRRSVDDTDQSLMSRLTPHLALSTHWENAVAETEPERGLQLKNKRDPDSDTPATDIFDVCCERGCSTEELVIYCGIWHGGAF
The following text describes a protein:
Function:
Negative regulator of salt (NaCl) tolerance probably by enhancing abscisic acid (ABA) sensitivity.
Miscellaneous:
MISCELLANEOUS: Loss of function contributes to the increased salt (NaCl) tolerance of cv. Sha.
Sequence:
MPNTSSSQSFTIFVDGWLIRHRYFVEQLMCASSLDETNRISLEEQQSLVAQFLSHCLQYYQEKFASVSLAGDNVFTFFCPPWFNSYAKLILWVGDFKPSLVFKLTEVSVADLTRHQKDRISSLKSETRRKEREVMRDFALVQQSVADPPVMLAARRVGAVGMVDGEETDLEEAMEVLKAGMAAAMNNADQLRCSTVGKVVEILTPPQAIKVLRTIGQLHLRLRDRDQERA
The following text describes a protein:
Function:
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
Subcellular Localization:
Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.
Sequence:
MSNVPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF
The following text describes a protein:
Function:
In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.
Sequence:
MLSEQTRTIIKATVPVLEKQGTQITKCFYGHMLTEHEELLNIFNRTNQKIGAQPTALATTVLAAAKHIDNLAALLPHVEQIGHKHRALQILPEHYPIVGKYLLIAIKEVLGDVATPEIITAWGEAYQEIADVFISVEAKMYKEAAWPGWKQFEVVGKDKVAEDIYEFTVKPTGDSGVDLAKLPIIPGQYITVNSHPVRQDNKYDALRHYSICSADTTNGLKFAVKLQTSTNNPDGLVSEFLHKDVKVGDVLKLSAPAGDFAVNKDLINQNDIPLVLLSSGVGVTPIVSMLEAQVKENPSRPIVWIQSAYNEPHVAFKNHVDNLLKQAKDAKKVVVLTDSQPRIDDKFLKENVPAHADVYICGSLNFMQSMIDHFQVLEHKNDMIHYEPFGPKMSTVKV