lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MCSHFSYFSLFNDFEFQIPHCRSRILCPSLAYFFDDFIHFLSICYLTDTLKVVTMETNFNSYEEVGSGLRSLESFHSTESDATFTSHFQNNFKPVNVLGQGGFGCVFEAEKHVMGKLTLWRGAVKRIPMKNGDNEVGKALKEVEAMLKFDHEGIVKFYDAWAEQPPEGWQKSTKSNKRYRKSDNVEDKGAKEFKDCFESILDQSYRVKISQTYILKTQFEFTFNGALTRIQFDRCPSSLRDDELLTVTRQIISCRLSEINEDFARDNKSDWALNDLRQEDRNPNHDAKQGASEDSETLSPSVINLYKSDDVNQILSSVYSYDLQPVARMLNVLSQDNNGQERSNTSKAWKELDSTAAATVREIRTMSQLNHPGVVKFASSWFESPTAACSTQNGRVEVKKTKPRDTSDRILLCNYSLAEWLRRQDSTPRNLSRMISWFKQIVSAVAYIHDRGFIHRDLKPSNILFSAPDRLKICDFGIATKLKQENELEITGTYTDIGSALYMAPEQSSWRYTSKVDVFALGLILAELGTVMTDNERREIFTNYRCGLPNNIRVERADVGEFVAWLTQVDRTKRPTCQEMLQHDNRQDLQQLSSKTCHSIEMDKTKHDPEFVPPGDDDWPSQVFRDQIISCLETEIEANVHDDANAREVEQRIFVKCQSKDEYMSSITTVINAMKYTSKSSDAGPSTSGTFQGSSFLTPLREYGPDEGNEFQKREKRFRITPKRRSNAGIGPRSARWSPHSPVPMEYASQTPSANTTHMPRPGSLSLQAPWAGPVEDSGGRPETSPWLSDQSTPYNILDAATGMTPRRDSLHDYFLPPQGPIRKAAMQQQALLVGNSSQSLASRWPGGDHPTAANPSLEGEATSHSALPDDEVKKQLMQRHLQDYYLQDYSGTPGTSTSGSHPIHGGGQMGYDLPPSYMPPQQQQQSPMQFNYMDRSSVYESMKMPSDDESVPKAKRDPEGKWIEEDFESETDGSSGAARKSAEESSESETEIETIRQQIIDITKDKATSRNRNRSRQRKLYALPSATKSTFVSKFEEDFAAKRILGVGKVGCVFSAESILDCSEYAVKRITVYSSEVVFEKVLREVRAISQLDHPAIVRCHGTWMEKPPRGWQKPNDDDIDPSFIYQQMQLCNYSLQTWLSENSTQSLRPLNTIKLWFIQIVSAIGYLHGKSLVHRNLKPSNILFVKEDRIKVSDIGIVTEFSKENYDSQRPELYRSPEHGNIRPWECTSKTDIFALGLIFAECCVVMTDEEREIEFNKYRNRVWSNLLSAIPEEELFVLSLRTRSRIHIKISYHVMRHSSSQHFLRLVYTRKAVSKKSSNNVSSARSRTKKEHKKEHQKDMKAWAGQLEKWNNELKNDVNFLEQEAKLQFKSKFVLPVDTELFQLENGTIFYLQHLDFFCRLYVKLEGRDVEVYLNGASQMGSHQNAIYWCEHRKRIVRAILNNNGEIQVHYVRGLLEASTI
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MRLTPTPNHIADERERERFVANLGGDDDGGRQLAGHANLEEEARISSACGGRRPQVIVCSRIVPGLKVGIHGSRSMNGTSDGIIFGGKGFPYGLPFISPNNILLSTITGTGAIIESTYVLIFVIYAPKMERTKIFGLVALAVAIFSTVALVSFFVFDGKTRKLFTGVFVDIFAIAMFASPLSIMRLVIKTKSVEFMPFFLSLFGLLCAVSWTVFGLINSDPFVIVPNALGSGLGIAQMILYAIYHERSRQHDNVVKDGSLERDLQITLEKQQPETHQLEHGRIL
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPPKSILKKTSVPANAAPGAKPANPRHLQVALHHANILEERKRVEAEVLDAIMTLMEYPAAPDADPKQPSAADAQFFRDAVIPFQPSDYDSLIEERNIYGKCGYALCPRPTKKARSTARKQFVDTQHGVEIVDRKTLEVWCSDDCAKRALYVKVQLSEEPAWMRQGGYADKIELLVDNTAEHQMTLPLRPKEATIPAPVEDDEDDIAAAWAAREDAMGDLALERGEKPGQVSKTNNDLVKDQITERLPTSAPPQPPSLSSQISEHTMAIEGHVPQLDRRDKDDEDEDDPQDWEKHLPG
The following text describes a protein:
Function:
Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.
Sequence:
MSKVAMVTGGAQGIGRGISEKLAADGFDIAVADLPQQEEQAAETIKLIEAADQKAVFVGLDVTDKANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQAASRKFDELGVKGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQAAAQELAPKGHTVNAYAPGIVGTGMWEQIDAELSKINGKPIGENFKEYSSSIALGRPSVPEDVAGLVSFLASENSNYVTGQVMLVDGGMLYN
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MATAPRPSMLATPRRPFGTSAPSNAEMRKVYADLENNNAVFDFSSIVSAVKTFSTRFRAYTENAISNIHDDKAEFDANRMEHRNQLTTLEREIEDTKASQGELWDTIAKERDQDAKLRARQQTLQAQKASVTQRCNELQAEITELRQNLEKKKEAKELQREKLKAQIDKNGPELRLLEAKTGCSVVPTKVGDQLKFTFNLMNADDWSKEYHFTIDVSSSRYKITSVSPKLDTSLQESLLQELNSTRKFYTFVKKMRAALRAQVEKERLEARDAARRGGH
The following text describes a protein:
Function:
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Cytoplasm.
Sequence:
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSVDIKKYQVLVGEPVRIKCALFYGYIRANYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFDKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLVCLVTIYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHYYRSYEYDVPPTGTLPLTSIGNQHTYCNIPMTLINGQRPQTKSSREQNPDEAHTNSAILPLLPRETSISSVIW
The following text describes a protein:
Function:
Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.
Sequence:
MYHGQLKNILLLSLRFIMDKLSYASDSSTSAWNTYLQQIERVAPYLGELSPWVDTLRHPKRALIVDIPVQMDDGTIRHFEGYRVQHNLSRGPGKGGVRYHPDVDLNEVMALSAWMTIKCAALNLPYGGAKGGIRVDPFSLSEGELERLTRRYTSEIGIIIGPQKDIPAPDVGTNGKVMAWMMDTYSMNHGTTVTGVVTGKPIHLGGSLGREKATGRGVFVSGLEAARRANIAVEGARVAVQGFGNVGSEAARLFAGAGARVVAIQDHTATLFNATGIDMKALTAWQTEHKQIAGFPGAETIASDAFWRLEMDILIPAALEGQITRQRAEALTCKLVLEGANGPTYPDADDVLASRGILVVPDVVCNAGGVTVSYFEWVQDMASFFWSEEEINARMDKIMTDAIVHVWEKAAEKSCSLRTAAYIVACERILLARKDRGIYPG
The following text describes a protein:
Function:
Acts as a component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec66 is required to attach or retain sec72 in the sec63 complex (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MVSIYVPLIYITILMGSMYGVSRFVRKSKNQESKPVSEEWFGENYSRNIFFSLLQQNPPAEDTLLKAALVLRATEGLRRLMKLKVSRMALNNLLNRGGVGDELIRKFGRLEKETELELMDIAKTANSLQPGWNQFIFQTCNEIIENEKIHSIIDNIPKDIDSISQRWQTEKILYEAADEELRIQAQKELGVL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MARTDEADALDLCFKSALVLEERMKVQDFAAKRGRENMHAIGTGSDLGFGGEMVSKTLDKDNMDAFRQFLYEEAKGPREVCQSLWELGLQWLKQGQNMKEEILVILEKLLAVLPLEMKTWGPVTFEEVAVKFSEEEWALLDLSQRALYWEVMLANYHTVSSLATLLISRPDFISQLKEEEEPREECAEEGARLTGNDQVEENEDENGQPERSEQVDNGRETSQEETEENDLQGLNISVPDCSQEWEGPYGCSKCGESFSDQSLLLEHRKSHPREKRFSCSLCEKMFNKKVYLTAHERTHTGEKPFKCLDCGKSFMSHVYLIIHRRIHTGERPFPCHECGKGFINKQALSKHKVVHTGERKYLCTVCDKRFAHKSDLVRHRRIHTGEKPYSCPTCGKGFIQKACLIEHELSHRKDQPYVCLECGKIFKRRKGFFSHMRMHRGESVPESTRNNEESVVTNSKTLAKEKLHPCPACGKSFKSRCHLLLHQRTHTGEKPYECSECGKSFSQQSSLYSHQKVHTGEKPFLCTQCGKSFRNKSNLARHHRIHTGEKPFMCQVCGKSFSQKASVVAHQTTHSKDKLYSCPDCGKTFKLKVSLHVHQRTHTGEKPYKCSRCEKRFIGHSLLIRHEKTHTGVSSLDTTQIILPVSELAMETTESTEICIAPRQYQARY
The following text describes a protein:
Function:
Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKHRIAGLASLPRACFHAQPQHQRRIYRLLQYNVAATRPLQSPSFSVAATLRAKAPKFASYQNSNARPAAELNENITQEEKDHFARRLEEDRGKQIRTPWHREGSDVPPVARQRSAGAMTKGKLLTTPSRMLKIILPLVTKDVNSDRKDIEPLALLVHPQQPISYLERLIQAELPMIKDKDGKERIPNVYFRAEDSMQSDAHPSEVEETTVSNDSEAVTDQEGHEDFEKVDEIRVDGKTERTGKLSNNVKNRKTPEEAAELRKGVGQGGVESYSGLGQDAASDKKAQRKFVRWSSSTEVGDFIRDAARGQEFAIEIEGAPEEIRVGVPSFNDRTYYLRMRLRKTSQKISEMADIKKECDRLAHKAAQRVAGAGFAGIVGWWGVVYYLTFQTELGWDVMEPVTAKDFDLRKWEALIDDGNTLRKEIKAIANEYDVEWDELKDEKDEKVREALKDERKKKKQGKGDESKEDDEPADKDGKKD
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAELGELEGKLRDVGEKLQSPPDDVDALLKLIHEAEIYILKVEQAPSESMISAITPAMKALIKKELLDNSSYEVKLSVVSCISEITRITAPDTPYDDDVMKDVFSIMVGSFEKLDDMENPLFRRIVAILETVAKVRLCVVMLDLECEDLILQMFHNFFTTVKPNHPENVTNCMTTIMILVIEEDDEVEIPIAECLLKHAKSELKETSAASFELAEKVIGACSEKLKPVFLQLLKGTSLNEYDNIIATICEDSSDVKEDMDADPSGKDVVDDGKLSERTISDELPQEPAKLEQDVTQTTAIGSGATPVDNGTESAAANPKELSNPDSEKKDGVKQSAKVANGASAETSERVDGSPAMVKSKRGRPPGLKSLEKKAAGKKVLGLKKVEETTDSTGKLSKQSSKDDSKSSTRKASGAGSSKKQQKISLKQKDETDSKEDTAKDLSLKEMVSPKSVSKGSAKTKGSQGQDNNGSKRKRSQEDEQETPRSRKNKGLDASLVGARIQVWWPDDKKFYKGIVDSFDTASKRHKIAYDDGDVEVLLLRDEKWEFVSEEQDKTPDVASEISPKPRGRGRKGRGSSVQLKEGNAETPKSGGGDLPKKRGRPKGSSNGTPKSNISATSSKSKGKAARKDENETPKVGSDLKKEAEEGSEDKATKSTEKTKDDLPEDGSNKSASKPKEASSGGKDLKGESKPSEGRAKPGRKPKVAGAAVAGEESKANVSAEKEKQKEAEGEAAAEVEQGGSAGGASTGGKKRRRKA
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Sequence:
MADKMEIVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFTKELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMKEGSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGWEHRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLEGGCSAPVAVHSELEENRLTLNASVLSLDGSELREEEKSITLPQELTQEHSLDAETNEEMKLFSSVIAPWVSQHAMQEAEALGVSVAKGLFDKGAGPILEAAKEEIAERRK
The following text describes a protein:
Function:
Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Sequence:
MSTRSRARKRSRVRSRTRRKDPIFVDGHRPRPMYVDYKDLELLSKMVNRQGRIMGRRKSGCTAASQHAVTAAIKRARFMALLPYVGE
The following text describes a protein:
Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATTENGTIPPGNVTNFEIPGTILKQSIPVIVILVISYFVVFILCVVGNSLVCFIVAKIPRMRTVTNYFILNLAASDILVAVFCMPFTLVDNIIIGGFCYPLPFQVGSYRSFIQALMEVAEEYYAIVYPTTTTFTGRITLYVTAGVWMLSLLLMIPQVLLIRENAWVENGQVILTLCQETSAFWRKIYTTVLFICCFIIPLTVIMYLYAQIGLAVWFKPTPGGDKATDEAKAVSLQRKMKVIKMLLTVVVLFALSWLPIHVITMINDYGSLSPDQLDVLWIYVYPACHWLIYLNSAINPIIYGFFNQNFRAAFRTLMMMRGLNVSSFQSRMVSQGTVIKRSTRKRPLKSTTAKSADQVSPEAV
The following text describes a protein:
Function:
Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes at genomic loci that are enriched for 5-hydroxymethylcytosine (5hmC).
Sequence:
MNQPGGAAAPQADGASAAGRKSTASRERLKRSQKSTKVEGPEPVPAEASLSAEQGTMTEVKVKTELPDDYIQEVIWQGEAKEEKKAVSKDGTSDVPAEICVVIGGVRNQQTLDGKAPEGSPHGGSVRSRYSGTWIFDQALRYASGSYECGICGKKYKYYNCFQTHVRAHRDTEATSGEGASQSNNFRYTCDICGKKYKYYSCFQEHRDLHAVDVFSVEGAPENRADPFDQGVVATDEVKEEPPEPFQKIGPKTGNYTCEFCGKQYKYYTPYQEHVALHAPISTAPGWEPPDDPDTGSECSHPEVSPSPRFVAAKTQTNQSGKKAPASVVRCATLLHRTPPATQTQTFRTPNSGSPASKATAAESAFSRRVEGKAQNHFEETNSSSQNSSEPYTCGACGIQFQFYNNLLEHMQSHAADNENNIASNQSRSPPAVVEEKWKPQAQRNSANNTTTSGLTPNSMIPEKERQNIAERLLRVMCADLGALSVVSGKEFLKLAQTLVDSGARYGAFSVTEILGNFNTLALKHLPRMYNQVKVKVTCALGSNACLGIGVTCHSQSVGPDSCYILTAYQAEGNHIKSYVLGVKGADIRDSGDLVHHWVQNVLSEFVMSEIRTVYVTDCRVSTSAFSKAGMCLRCSACALNSVVQSVLSKRTLQARSMHEVIELLNVCEDLAGSTGLAKETFGSLEETSPPPCWNSVTDSLLLVHERYEQICEFYSRAKKMNLIQSLNKHLLSNLAAILTPVKQAVIELSNESQPTLQLVLPTYVRLEKLFTAKANDAGTVSKLCHLFLEALKENFKVHPAHKVAMILDPQQKLRPVPPYQHEEIIGKVCELINEVKESWAEEADFEPAAKKPRSAAVENPAAQEDDRLGKNEVYDYLQEPLFQATPDLFQYWSCVTQKHTKLAKLAFWLLAVPAVGARSGCVNMCEQALLIKRRRLLSPEDMNKLMFLKSNML
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MGIFDWKHWIVILIVVVLVFGTKRLKNLGSDVGEAIKGFRKAVNTEEDDKKDQPAAQPAQPLNQPHTIDAQAQKVEEPARKD
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking and spindle migration.
Miscellaneous:
MISCELLANEOUS: Present with 11300 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
Sequence:
MSQSYEAGNANMGQGEDDEFDGYFEDFDNDIMPNSNNGQRVGTNAGLSFNDEVNVNDDDFLDIYNMSPRERLMHNIRKNVQKLQFYFYSLRLWQQIIIVLLGIMLMIMGILLLVFHNAILHKVVVTSNDLREKMSTHFILMVLIFFVAFPPMIGYSLLSTTTGLIYGVSFEGWVTLALGSVTGSIASFVVFKTILHSRAEKLVHLNRRFEALASILQENNSYWILALLRLCPFPYSLTNGAIAGVYGISVRNFSIANIITTPKLFIYLFIGSRVKSLAESESTGSRVFDLVSIIITLLILSLTAWLLYFKTKKRYLELQNRDRQVSTDQLPELSFEV
The following text describes a protein:
Function:
Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.
Miscellaneous:
MISCELLANEOUS: Present with 672 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MEYGHHARPDSKRPLDEGSPAAAGLTSKKANEALTRNRELTTVLVKNLPKSYNQNKVYKYFKHCGPIIHVDVADSLKKNFRFARIEFARYDGALAAITKTHKVVGQNEIIVSHLTECTLWMTNFPPSYTQRNIRDLLQDINVVALSIRLPSLRFNTSRRFAYIDVTSKEDARYCVEKLNGLKIEGYTLVTKVSNPLEKSKRTDSATLEGREIMIRNLSTELLDENLLRESFEGFGSIEKINIPAGQKEHSFNNCCAFMVFENKDSAERALQMNRSLLGNREISVSLADKKPFLERNEVKRLLASRNSKELETLICLFPLSDKVSPSLICQFLQEEIHINEKDIRKILLVSDFNGAIIIFRDSKFAAKMLMILNGSQFQGKVIRSGTINDMKRYYNNQQNHSMKHVKPSCINMMEKGPNLQVKKKIPDKQEQMSNDDFRKMFLGE
The following text describes a protein:
Function:
Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSDLDEESQIETQIDAPIEDIIRGSELTTTTADKETLKSANELLDSLEHSHRVDLSLHLYSAYLLKRLLYKANEKKHFYEVNQFVKTQIKDNWTSWPNPNTIIDPSVDKLYEDIPEGIANVSVQPGEISNRALMHASDMMRVELDAQWQKFLSKSALDHDVTLDVDELNIPNEISRNILVKLDSLFEGLHDKIAKENEFDVRQDKHSNNIRANQIDDEPMQANRRIKYTYHDLVSRGCEMNEDMTDIYMKSLELYNDIPEKYKKRKFRLPKQILKKYHQPKKTSSYLKELLSKTREDFIPVEKLLKDKRLTSKDKSKLQRLNREETEDALNKRTFFQVKGYLEDENEISDYELDDCLIELPNGNI
The following text describes a protein:
Function:
Palmitoyltransferase specific for casein kinase 1.
Subcellular Localization:
Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MGSLFLAASQGELDTVKNLISSEKIDVNATDEGGATALHWAALNQQIPICKFLLEHGADVNAIGGDLQAAPIHWAAKRGSVKTVHYLVQHGADPLLKDKQGFNCLHLAVHAASPLLVVYLLHLDISVDLRDDQQHTPLMWASYHGNEPITNCLLRWGADVLATDEDKMTPLHWSIVGGNLKCMKLILKEGGIPCTAVTANLSGQLKTPWALASELRVSHLFKQALISNGLKVKETSEEPEKWVVVPSKFQFSQKTFIIFCFLSSFIITGVFFFIMSICPMVISLIIAPLWIYFTFKYITTCIHANIDIVHFYLETPFLAGIFSSIFFWVWCHSLLYIVPKTLPIKPLSSLLFVLISFTCIGLYVRTAFQNPGYVDKIGAVVQRREEISKLLDKDLFNQSHYCLKCFQVKPPRSYHCGACKRCINRYDHHCPWTGNCVGARNHRTFLLFVFTLSTLIPIYFYVAFYYLQNIPIQKKYESYRCLFISGTICQWSLKDMFVLVASLTLFVNWCWVVVLAFTQICQVAHNVTTAEFRLFKRYGTLVPPTKQNSSPKNGHGIHGSFLRTVCGILGLDQCILLIRESNCFVRCFPSRAELGSQNSTSLSRNLSTVNPYDEGSIIKNCKTFWKQNFLNDGRQDEATRHV
The following text describes a protein:
Function:
Releases mononucleotides from RNA in the order of 3'-GMP > 3'-UMP > 3'-AMP > 3'-CMP.
Subcellular Localization:
Lysosome.
Sequence:
MRLIAALLSVLLIASTAQSTVTIYESSKPGDFDFYLFVQQWIYSYCDSQTCIQNKEREAFTIHGLWPENSDGSYPSFCSGPSFNVNAIQDLEDQLNFDWPSLTGPNTDFWTHEFSKHGTCSITGPITDIHDYFATGIKLYTEFNITAALESENIYPSDSNTYKPVDITNAITTHFGGKPGIQCSSGQLSTVAVCIDKNSLSIMDCPDLQGWSCSGSVKFPSTA
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular Localization:
Nucleus.
Sequence:
MPKFFCDYCDVYLTHDSMSVRKAHNSGRNHLRNVVDYYQQIGHEKAQSVIDSITSSYAAEGQAHANPMLPQNQPGGVPPGLGFPPPGAGVPPFPPFPGGMPPPFPGMPGGAPVPPPGAFGAPGVPGGIPPPGAPGARGMPPMPPFPGMPGAPAGIPGVPPPMPGPGGLPFPPPGGLPFPPPGAGNFPFPPPGAPGAFPGMPPFGAPGQGPPGADKR
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTLVELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQKNPADDDPGEDGLYRMGTVATVLQLLKLPDGTVKVLVEGEQRGQVERFIEEEGHIRAAVQAIDDANVGEREAEVFTRSLLSQFEQYVQLGKKVPAEVLSSLNSIDEPSRLVDTMAAHMALKIEQKQDILEITDLSSRVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDIDEGHNEVEELKKRIDAAGLTKEAHTKATAELNKLKQMSPMSAEATVVRSYIDWLLNVPWKAESKVRHDLAKAEDILDADHYGLEEVKERILEYLAVQKRVKKLKGPVLCLVGPPGVGKTSLAESIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGRLIQKMTKVGVRNPLFLLDEIDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTANSMNIPAPLLDRMEVIRLPGYTEDEKVNIAAKYLIPKQVQANGLKKGELTFEEGALRDIIRYYTREAGVRSLERQIAKVCRKAVKEHAKLKRIQAVVSSETLENYLGVRKFRYGLAEQQDQIGQVTGLAWTQVGGELLTIEAAVVPGKGQLTKTGSLGDVMAESITAALTVVRSRAQSLGIAADFHEKRDIHIHVPEGATPKDGPSAGIGMCTALVSAITQIPVRADVAMTGEITLRGQVLAIGGLKEKLLAAHRGGIKTVIIPEENVRDLKEIPDNIKSDLVIKPVKWIDEVLQIALQYAPEPLPDAAPEMVAKDEKREPDSKERISTH
The following text describes a protein:
Function:
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKNTSTVVPSSLLEKDPAFQVITITKETGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITRAKLRSESAWEIAFIRQKSDNIQPENLSCTSLVEASGEYGPQASTFSFFSSPPEILIPKTSSTPKTNNAILPSCEIKTGYNKTEQIPITSSENCSVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDDVNVGAHEISNILDSQLLPCDSLEADEMERLKRERDDAFKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFIEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRNIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEADFSRELPNQRS
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLFHVLFKASALAFYLLSALFTDSFVIIFVITVVLAALDFWVVKNSLARINKKDSWLFWWTLHLNAAAWIIFATLSLLRFQADYLLVVGVCLSRGIANIVGFTKYRKETIITIVITSYLTALRECREWAAQPGQSNKKFMKLRELIYATAFLREKEKRSIDLVVGRGPFLNSNWLGGFVYWIEDARKKIQAFASQTIASRVSSTIQSAFGVV
The following text describes a protein:
Function:
Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (eft201 or eft202) to diphthamide (By similarity). Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKVLGLISGGKDSCFNLMHCVSLGHEVVALANLHPEDGKDEIDSFMYQSVGHDVIPLYAECFDLPLYREKIGGQSINQNLDYQFTEKDETEDLYRLIKRVLTNHPDLEAVSTGAILSTYQRTRVENVCKRLGLKSLSFLWQKDQEKLLNDMVVSGLNAILIKVAAIGLTRKDLGKSLAEMQDKLLTLNKKFELHPCGEGGEYETLVLDCPLFKKRIVLTDKEVVEHSSGEVCYLKVKACVKDKPEWQPISLKSELVPNEELLGEEYSHIYHTISKKYELIDDQEETPTSLIPIPLRESAFQQKKGSFLVLGNVVATKGSYNTFQGEAESAINNLNELLGTYGYSNKNVYFVTVILSSMSKFAEFNSVYNKYFDFTNPPSRSCVAAPLASEYRIVMSCIVGDVTEKRALHVQGQSYWAPANIGPYSQSICANGVVFISGQIGLIPSVMELKLHDKIFEMVLALQHANRVAKAMRVGSLIACLAYVCDSRDADCVVKIWSEYTKNTGESSPVLVALVDALPRNASVEWQLLYNDSSCDVPLLSSLVTNQTLFGSDTAWDVALLNQNGLRMESSFIHHEHPSAYAIVLNNAFPNSQLLHVRYTARDQNV
The following text describes a protein:
Function:
Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane.
Sequence:
MSGTGDSRKRSARGSRAGKGEDARGGRAQTDAPRKAGSLIQQLENLLLPASSCLAPGDRARFRASRHHPFFPNLTVSFFLFFFLFPSVLSLPFPRLLGSVFSPDPQTPFSFHGLQISSLANSSWTRTDCLGWLGELQPYTWRNESDTIRFLKPWSRGTFSDQQWEQLQHTFQVYRSSFTKVLWEFVKRLHAELPLEIQGSAGCELLQGNTSESFLRAAFQGRDVLSFQGMSWVSAPDAPPWVQEVCKVINLDQGTKETVHWLLHDICPELVRGLLQTGKSELEKQVKPEAWLSSGPSPGPGHLLLVCHVSGFYPKPVRVMWMRGEQEEPGTRQGDVMPNADSTWYLRVTLDVAAGEAAGLSCRVKHSSLGDQDIILYWAAIKISRDSSHHIHLSGLQDLRALALRI