lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 2500 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MVKVKSKNSVIKLLSTAASGYSRYISIKKGAPLVTQVRYDPVVKRHVLFKEAKKRKVAERKPLDFLRTAK
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MEARHMLVTILLLSFVFMNIMKVEAQKVIGYPAIGRDGARGCSPKDPSCPQQPEKPYKRGCEKITRCERDRRKQAHLRNPRKVLDVVAVMAKAKQLY
The following text describes a protein:
Function:
Serine/threonine protein kinase that phosphorylates proteins on serine and threonine residues. Collectively with CBC1, acts as a negative regulator of stomatal opening, probably via the inhibition of plasma membrane-type ATPases (AHA1 and AHA2) activity in guard cells, but in an abscisic acid (ABA)-independent manner. However, at low concentrations of CO(2), together with CBC1, stimulates stomatal opening via the inhibition of S-type anion channels in response to blue light (BL) and red light (RL), thus being a key component to maximize photosynthesis in the light under low CO(2) conditions. Required for temperature decrease in leaves. Downstream target of HIGH LEAF TEMPERATURE1 (HT1) during low CO(2)-induced stomatal opening.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MKEGKDGFVRADQIDLKSLDEQLERHLSRALTLEKNKKKDEEDTTAVAIGGSASSSPVTLNGGGFVGKRKQRLEWEIDPSKLIIKTVLARGTFGTVHRGIYDGQDVAVKLLDWGEEGHRSEAEIVSLRADFAQEVAVWHKLDHPNVTKFIGATMGASGLQLQTESGPLAMPNNICCVVVEYLPGGALKSYLIKNRRRKLTFKIVVQLALDLARGLSYLHSQKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSALAAVMKRCWDANPDKRPEMDEVVPMLESIDTTKGGGMIPNDQQQGCLCFRRKRGP
The following text describes a protein:
Function:
Regulates the timing and orientation of distal tip cell migration during gonadal development. May act in parallel to cacn-1 and Rac GTPases to control the anterior and posterior migration of distal tip cells.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Expressed in the nucleus of distal tip cells and in the cytoplasm of germ cells. Localized to the peripheral chromatin region of the nucleus.
Sequence:
MSSVSSDIDGPPETKRFRIDVDTQVGIDTPSVSTNCAPPVAGEASQDGQSPAAPSSASYRSSNSSVISSSESPIKDEDVDVHDGQDDTEDIAMDVSGSTGSIVNNSEIFEMLNKTFGGVFNCDLEGIMRPSALMHPSSPPTPIQSAGIPGALAVAQSPAAQLFSGDDWSWHRNPAASIRSGGTNKQTPVWKYFVYNKTENLSRCIVGDCTYMLKGPHTSTLACHLKKHTREYSEFQKLKTEYSRTKLDQQPKIPDGAPHPLTLQTQNTPRQTGSPASTCNTNSNTSSSVSSGSGIGSGSGSTMDLSMKKPKKEPSSAKLNEMLFNGLRQATNNSNGSPPTTPHAPQLPNIPSFVTNMMLQMNPLHMMLAQSLPGATPPTPTSSNAGLNALQQAGLTLAANGQIIQSKKWRNDDKKQKELCTKFALALATSHVDFEVVQNPLWKEVFEMAQPKFSIPTESQYEHIVNSTSHKLIQSLKSQLSASKKLNLLLDITKITADISRVTVSVALTGGAGNSYETQVILLAFRNINGNQSEDLTAVFEKVLQDYNISPSSINRVICSGLNELAEPAELPKQMDSFSSRLANCFKSWLETSPTVEVLKKNVYAMLVSYLTVPAAIQLASQMLKAKFEVPLTEPFHVIVEHLVAHRDIYQMNMEGITLISEREWNKVTGIHHLMNIFKPFMTYSTDMTTVDTVIPTIVQIQNVLEKDIYHLGDIGSDLLTSLKQTVAPIMNPEHENFDSTYIQATALNPQLAVTLTSDQMTTAKSLIETEISRRTKKMRKAQSDKKLAMGVDSLLANVMRKNDGGSDGGCETALAIYGDLFQSITGNSSESKENIVNQYFDEISSTTSVESMFMLRTFGNPMQAPLSYWKSCSSRCSELSDLATELLSIPIFTLTAERVLSFSPDSSSLNTNLILTNLDSTDQFEKQVLLRFNRQIVSKLFN
The following text describes a protein:
Function:
Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by promoting decapping and leading to accurate 5'-3' mRNA decay. LSM1A and LSM1B are essential for the formation of the cytoplasmic LSM1-LSM7 complex which regulates developmental gene expression by the decapping of specific development-related transcripts. Required for P-body formation during heat stress.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MSWSAPDDILLSTSLAGFLDKKLIVLLRDGRKLLGTLCSFDQFANVVLQGACERVIVGEQYCDVPLGLYVIRGENVVLIGELDHEKDELPAHMTCVLEAEIRKAEKAEREARDLKGTMRKRMEFLDFD
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MDKCSIIYSPSPIIDTSVDNEDHTFTYFYRKSFNGTKLTTLHHPDNKKTQVKKMRRAKDDTAIKSKQKKEVSKIDQRPPLKPTENTTTPVKEKRNIDDSEHLVVKNPLTSPISASGIGLLDASSAALNLLGSESDTEDGKSQTTENVKSQNRKSVTKNKLKQIQDEAKVTPLKIDKTTMKVISKKKLLVHVVATRELPAVNKSSKKEDKTCARKSVRLSTKKQVPEKSKSRSSNRIKSAKKEKKYDSDESNVSESLSVNSESSTNKTKSNLRRSTRLSVYQPKKLEDEFEDDLSDEDVNFDGTKHVPSSSSSDEGDDDEEEEVVKVRTKRRKSTMKKSNTVTPICIKLPKERTPYIPKRKTVVKTAENTFDEAQKRLHVSAVPESLPCREEEFQSIFSFIEGKIISGTGGCMYISGVPG
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNYLEGTIDFAGQLRCQKYMNYGLCTSAVISYIYGYLVQDSYCVIKLFLILASLVALVCLPAWSMYNKNPLKFQKKKE
The following text describes a protein:
Function:
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MGPGIRQDDGGVCRGGVGSRTMTPLRAGILSAIATVILDQASKLWLLHGFDLAHRGAVRVTPFFDLVLAWNIGISFGWLQNDSQAAQLALMAVKAIAVVALAIWMARSHTLLATVALGLIIGGAIGNGIDRLAYGAVVDFALFHLDIGGNTYNWYVFNLADVAIVAGVAGLLYDSFLGVPAAKAP
The following text describes a protein:
Function:
Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane.
Sequence:
MGAGLVSACLPISYVLLVHLFDRNGTDRNDPESVKRRFKGALLSNFVSIVVTAFYLRDYTDSPMLEMGVRWDNIGQSITYPFILMNAFYLGQFVMMQIDRTLWHYFDWYEWKLCFNSWVWRRDIIVGPITEEIVFRACSSTLMAHVYGPTMTILLNPIPFAASHFHHIWDDQRRGYSLAHSILQRGFQFCYTYLFGAFATWLQLTTRHAIVPIIAHAFCNAQGLPLWLEIPNYPKRRDRLTLYAAYSVGFAAFVHLLYTRNGMPTP
The following text describes a protein:
Function:
Putative oxidoreductase.
Sequence:
MLSSQHQCLLLLALVLLILDSTFGFQGGRVSVLPSPPAAHQPQHQPPYHRHRRQSYTAQLRMGAAQSSDLPDSTKQEYQNKSILITGASRGLGRSLAKSLSSCNPSLLVLSGRDEVALSEVKEECLQIDNGEMKVEIVVCNLADKSSVDKLATSALQLSRRHTNSPIDILINNGGISSRSSFLQTKLESTSSPVLLWQRVWYQGMAAKKRGKIVWISSVQGKLGTPYRTSYAASKFAVQGYCEALRSELSSNNISVHIASPGYIRTNLSVSAVMGDGKAYSKMDDTTANGADPDDVACTILNSVAKGESDFVVAATFAAKAALWLKFLLPSLLESKLVKRFEKGEVEAKKTE
The following text describes a protein:
Function:
Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular Localization:
Secreted.
Sequence:
MAKLIPDALLLIVSLINIFTVDTSFSSEGDLHSSPVFSGGSSSVGHQQKEAKLVSASHAHTRSKRCTCYSFKDRECVYYCHLGIIWINTPQRTVPYGMSSYRSPQRLRRSSGTISVVLRRCLCTDHNDVHCYNFCDASSENVSEGRLRGRSPW
The following text describes a protein:
Function:
Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
Subcellular Localization:
Secreted.
Sequence:
MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPGYATAEGNSSGSITCLQNGWSTQPICIKFCDMPVFENSRAKSNGMWFKLHDTLDYECYDGYESSYGNTTDSIVCGEDGWSHLPTCYNSSENCGPPPPISNGDTTSFPQKVYLPWSRVEYQCQSYYELQGSKYVTCSNGDWSEPPRCISMKPCEFPEIQHGHLYYENTRRPYFPVATGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAGYEEEVVKFAVFSRVMLILWQMVSNNLIPDHDAGVFNPPVRHPVGIGDQFMDVLFGGFSHWDSAHFLYIADNGYTIQKHFAFFPLFPTTVKTVSETVLFPLRFFMNGHSALLVTAVAVNVLFFVAAAFVLFRLSIMTLHDRQLALRTALLFCINPAGIFMSAAYSESLFAFVSFYGMLAMERKQYLPATLLFALSSTTRSNGIVNCGFVVFFTAKELMSKLRLPLTEFSLQDVLFIVLKLISTVCYISAILAPFVAFQYHAYHLYCGDFKREKALVLWHPLFPTDNEEYLPPGSTTIPPWCNWTVPSAYSYIQDSFWDVGFLRYYQLKQIPNFILAAPMIALCGFAVYSYCRVNWSLCRTLGLGAERKEDDEKPRTGFNSPQVFVYIAHLSFLLLFGVTNMHIQVVTRFLASSSPVIYWFAAHLTRDDPQHSKTNPAASENTVYPTNPVLQQIHNWKSARRTTQAVLGYFLFYNVVGVALHSNFFNWT
The following text describes a protein:
Function:
Involved in heme iron utilization. Catalyzes the degradation of heme to biliverdin, with the release of iron and carbon monoxide. Release of iron from heme may play a crucial role in the pathogenicity of H.pylori.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNRIIEHMNAHHVEDMKGLLKKFGQVHHAENVAFKSVDPQGIVIGYNHNQTLRIEFNHEVKDPKDYKNAIIELCQSVEKTHDLKGVEEEVKAFKESFDSVCLATLHPNGHVVCSYAPLMSDGKQYYIYVSEVAEHFAGLKNNPHNVEVMFLEDESKAKSAILRKRLRYKTNARFIERGAEFDKAFDSFIEKTGGAGGIKTIRAMQDFHLIALDFKEGRFVKGFGQAYDILGDKIAYVGDKGNPHNFAHKK
The following text describes a protein:
Function:
Essential for aminobenzoyl-glutamate utilization. It catalyzes the concentration-dependent uptake of p-aminobenzoyl-glutamate (PABA-GLU) into the cell and allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyze cleavage into p-aminobenzoate and glutamate. It also seems to increase the sensitivity to low levels of aminobenzoyl-glutamate. May actually serve physiologically as a transporter for some other molecule, perhaps a dipeptide, and that it transports p-aminobenzoyl-glutamate as a secondary activity. The physiological role of abgABT should be clarified.
Miscellaneous:
MISCELLANEOUS: It is suggested that in wild-type strain abgT would normally be cryptic or not expressed under conditions of growth on minimal medium. Altering the expression of abgT from its wild-type context appears to be the mechanism for obtaining the growth phenotype.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSMSSIPSSSQSGKLYGWVERIGNKVPHPFLLFIYLIIVLMVTTAILSAFGVSAKNPTDGTPVVVKNLLSVEGLHWFLPNVIKNFSGFAPLGAILALVLGAGLAERVGLLPALMVKMASHVNARYASYMVLFIAFFSHISSDAALVIMPPMGALIFLAVGRHPVAGLLAAIAGVGCGFTANLLIVTTDVLLSGISTEAAAAFNPQMHVSVIDNWYFMASSVVVLTIVGGLITDKIIEPRLGQWQGNSDEKLQTLTESQRFGLRIAGVVSLLFIAAIALMVIPQNGILRDPINHTVMPSPFIKGIVPLIILFFFVVSLAYGIATRTIRRQADLPHLMIEPMKEMAGFIVMVFPLAQFVAMFNWSNMGKFIAVGLTDILESSGLSGIPAFVGLALLSSFLCMFIASGSAIWSILAPIFVPMFMLLGFHPAFAQILFRIADSSVLPLAPVSPFVPLFLGFLQRYKPDAKLGTYYSLVLPYPLIFLVVWLLMLLAWYLVGLPIGPGIYPRLS
The following text describes a protein:
Function:
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane; Multi-pass membrane protein.
Sequence:
MARRPGAPAAYGEDFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHEEAALACLAVDPAILLIVVGILMFLLTFCGCIGSLRENICLLQTFSLCLTVVFLLQLAAGVLGFVFSDKVRGKVSEIINNAIVHYRDDLDLQNLIDFGQKEFSCCGGISYKDWSLNMYFNCSEDNPSRERCSVPYSCCLPTPNQAVINTMCGQGMQALDYLEASKVIYTNGCIDRLVNWIHSNLFVLGGVALGLAIPQLVGILLSMILVSQIKDQIKLQLYNQQHRADPWY
The following text describes a protein:
Function:
Plays a role in papillomavirus genes transcription.
Subcellular Localization:
Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm.
Sequence:
MASVLSRRLGKRSLLGARVLGPSASEGPSAAPPSEPLLEGAAPQPFTTSDDTPCQEQPKEVLKAPSTSGLQQVAFQPGQKVYVWYGGQECTGLVEQHSWMEGQVTVWLLEQKLQVCCRVEEVWLAELQGPCPQAPPLEPGAQALAYRPVSRNIDVPKRKSDAVEMDEMMAAMVLTSLSCSPVVQSPPGTEANFSASRAACDPWKESGDISDSGSSTTSGHWSGSSGVSTPSPPHPQASPKYLGDAFGSPQTDHGFETDPDPFLLDEPAPRKRKNSVKVMYKCLWPNCGKVLRSIVGIKRHVKALHLGDTVDSDQFKREEDFYYTEVQLKEESAAAAAAAAAGTPVPGTPTSEPAPTPSMTGLPLSALPPPLHKAQSSGPEHPGPESSLPSGALSKSAPGSFWHIQADHAYQALPSFQIPVSPHIYTSVSWAAAPSAACSLSPVRSRSLSFSEPQQPAPAMKSHLIVTSPPRAQSGARKARGEAKKCRKVYGIEHRDQWCTACRWKKACQRFLD
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane. Membrane.
Sequence:
MKRFLLPALLSALMIAEVHAESFTVSDIRVNGLQRVSAGSVFAALPLNVGETIDDQALVQATRSLFKTGFFQDIQLGRDGNVLVVTVVERPSISSIEIEGNKAISKEDLLKGLKQSGLAEGEIFQRATLEGVRNELQRQYVAQGRYSAEINAEVIPQPRNRVALKININEGTVAAISHINVVGNTVFSEEDLTDLFELKTTNWLSFFKNDDKYAREKLSGDLERLRSYYLDRGYINMDIASTQVSITPDKKHVYITVNINEGEKYTIRDVKLTGDLKVPEEEVKRLLLVQKGQVFSRKVMTTTSDLITRRLGNEGYTFANVNGVPEAHDDDKTVSVTFVVDPGKRAYVNRINFRGNTKTEDEVLRREMRQMEGGWASTYLIDQSKARLERLGYFKEVNVETPAVPGTDDQVDVNYSVEEQPSGSITASVGFAQSAGLILGGSISQNNFLGTGNKVSIGLTRSEYQTRYNFGFVDPYWTVDGVSLGYNAFYRKTDYDELDVDVASYSVNSLGAGMSIGYPISETSRLTYGLSVQRDQIDTGRYTVDEIYDFLDKEGDNFTNFKASIGWSESTLNKGVLATRGHSQSLTLETTLPGSDLSFYKIDYRGQVFAPLTDNYTMRFHTELGYGDGYGSTERLPFYENYYAGGFNSVRGFKDSTLGPRSTPSVARNPDGTPMKNQGPDSKGRYTDPDQDPEAFGGNILITGGAELLFPLPFVKDQRQLRTVLFWDVGSTFDTDCPTKTTTNCDGIKTDNLASSVGVGLTWITALGPLSFSLATPIKKPDNAETQVFQFSLGQTF
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
MDTRQDTHLAKLNNVTIRPASAGSLEEEISRIIEDEPREHPLHLLDLDDLVGKHLVWLRSMPRVTPFYAVKCNDDPAILATLAALGTGFDCASEAEMRTILALGVTPDRIIFAHPIKSVQALAFAKAHGIRRMTFDNECELEKVAREYPEAELVLRIRHDSDRVLIALGKKFGCDARGDGRVLLARAQALGVAVIGVSFHVGCGSLDADCFYHAIASARSVFDYAKDELGMRLWLLDVGGGFPGDNDKPIDQYAEAVSRALQEFFPPEQDEEVYVLGEPGRFYVGSAATLLTTVQGKKIVRDDAGQIQQMMYYINDGVFGTLFDWLSLREIKDLKRAVPLVRREREHEPAFPTTIWGPTCDSTDIVCEDVPYPEHHIGDYIVFENLGAYGMTFATNFNGFPKPTVQVYVKEHTWNMLHSIAGTDWRQKTLTFFERECPRKGPEQSSDQL
The following text describes a protein:
Function:
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Chromosome. Cytoplasm. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes (Probable). Predominantly nuclear.
Sequence:
MENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKDAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSGSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLTPRLGTPFSQDSSYSSRQPTPSYLFSQDPAVTFKARRHESKFTDAYNRRHEHHYVHNSPAVTAVAGATAAFRGSSDLPFGAVGGTGGSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYMPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEQESTEEEEEAEEEEEEEVPRSQLSSSSTSSTSDKDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPPKKRHEDLVPPAGSPELSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKRDDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPADTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.
Sequence:
MGHVEGNLQLVNAISGRSIGTHVQYFMTMEDLKRFVIQQWHIPGPEIFILQPYGGKFKRGHFQDMVSEAKKAVARGRVRETSVLYVFDRRLFDGGEEALAQATRHDSTTLVRPLVSPLEDAEAEVGERAAASLLTTNLGWLSALEIDVRYFHACIEGWVQQLANMKECLSVLLQYLELYSFDIEKLYHASAEAVDGVRQRCASNDWRQKNQELLETIDAVASRGKLVQFVDLEEMSEAEERLRELERLLSKKLSLFRGALDENHAIRQEIANHIKEVGTRYQDNISNYELEAQILGNFKDMVKKVKEDTRTILDLDTTKVSPDLMTSAVSLFKEMKSTAIPALYTVGLSLFTQASKCMETKASLQREMLVILADIAVAQVNIVDAKNSLLQQVNQDISALHTTEQQLLRVSELPVVYGLYLIELYRRQHWITGLDRYYSEHTKEIQSVLQRELVFREKWSSDFSSYSEIFQWQDDKPQLAKLFSNASPLEVGRPCIDIGTIQTYIEMLARCDVAEDSQTLLKKTLSEVSRFQFIVKSPLAGSVSKDSTDSMNEVIEGYKNRINKLELLLHSTQFSNTSSWPTGVLNSNSLNVFHNNIASINEKLLLSDYKSRDSIMSGKSNEKELQSQLVELQKQLEEAKNEAKRVQQQLKTTKTQLLNGEDERTAYKETLSILNAELSKLILNQEEQKQELVIAAKDFQEKLDVSMRQVNDLLKQVNFWKSKCGDLDKIKQDLLANMATKETDFNNRCTDYERNIVELQRQLSEKCDATNERSVTSTSADVPGETKEYIESLKEVNRRLEEDMFAVFAGNIVLLENIGLLLSRGPDNKLQIIRVKGLRKNIDDSIIKDSSPVINSHMVKSTVFQDVKNLFDELQLSQGVNDQLHFVSELERFYEEDLFQTSVIKRFTDVENLAKKLRKENKAKKSVIERHNKDKITFRDLKVGDLALFLPTRGVAGSLTSSVASSLASSFSSVDLSTPPPPLPTASQSLIKVTPHKPHRNKSTPWAVFTASELGVRYFLKDSEELVKGKDWFVGKIQSMEKYTVNGDSRNPFKLPEGMVWYEVVASCTKEL
The following text describes a protein:
Function:
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSAKDNPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLNQAKPIYGGWLLLAPEGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAENKEIISGWLEMLIVYPRTNKQNQKKKRKVEPPTPQEPGPAKMAVTSSNIPSAEKVPTTKSTLWQEEMRAKDHPDGSSLSPIQSPGQSQAPLPSTLREPGLEDKEEESTMNGDRIDCGRKARVESGYFSLEKTKQDSKAEEQQLPPPSPPSPSAPNNRRSQVIEKFEALDIEKAEHMETNSSAGPAQSGETRQGRSEKRVFPRKRDFTTEATASAAGSAPEVSASPLSPHRRAKSLDRRSTESSMTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSTCYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTRKNLSLKLSVLKPRLENCVLSCINILCSLPEEKNKSSSSSSSSPAFEACPKPSEKQDQDQGDLDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERASAAEAPSAREPGGLDTDLGELERERARRREERRKRFEMIDSVDGPSGEDSGSRMEVDRSPVSPVAPETKPQNVHVEIEQRWHQVETTPLREEKQVPIAPLHLSSDDGPDRLPAQEITSLLEKELEQSQKEASDLLEQNRVLQDQLKVALGREQSAREGYVLQTEVTTSPSCAWLRLHKVNQDLQSELEAQCQRQELINQQIQSLKRSYGEAKDVIRHHEAEIQSLQARLSNAAAELAIKEQTLAKLKSDLKMEKAKVREQLEEWQHSETTLSSQLRASEQKLKSAEALLLEKTQELRDLEVQQALQRDHQKEVQRLQERIADLSQQLGASERAQALMEEKLQKNYELLLDSCEKEKQALIQNLREAEEKASDYEDQLQDHEQQMEILQKEKLNATFEGSEMVHQLEEELQVKEASVQKLAEHIQSLQGERDQIRTRFQELLDQVARSDGEVAELREKLEAREADYLHLEGTHRRVSDRFRDVHAALKGKEEELQRIKALHEKIVAKKDQDLNEAMVKMVALGSSLEETEIRLQAKEGVLRRGANAHPGGPDDECPTLDADGEGVALLGQPEQAQGGPPATHSPPQVNEGLEASQGEVSETPGLEAGDVVTLSESAEPHDREGLQKAAPKCEGGTPGTKRQRIRFSSIQCQKYIHPDGSEKNWASSTSSDTSQDRSLSEESMSSEPALTGLSAGTGAPEAYLSIIHSLETKLYVTEEKLKDVTMKLENQQGQNQEALIALHQQWAGTESQLRDQLQTSLSQVAALASQLEDERKERQTVMKKHVGELGDFRVKNSRALSCLEACREQLRSLLKADREKEGDLGLATLSSVEIILSDAVRVLRQIPSWPGEAREESLPAGDKVTPQFPGLTHQDQLKLLAEKTSFEASLINQIAESLTDASSALSRTLQEIDLSTKVSLEPTSGSRTAGTSAEALCKKLLLESQFWSQVEDLRKQLGGLGSEGGGGNQADAGPPCFPRDSISALADATLVKAELGFAVQKLRESFHDRLQTLEDNLRGTKTALEQYKGMLGEIIRAHGTPSLESVVRQISETLEPQAGIERGGLTEEDGKRFEPEPAPGPAEGLDLPRAPDQGEEEETLVSIQEQLAQQLKEKASVLEEIAASLASLPPGEPPGDQREVLEASQGVSDLTSLGGLSRCSSLLVRDAITQAQVCYAGCRIRLQYEKELRFYKDSWEKAGASCQERARAVAALRLEYEELLRKQKSEYLQVIAIVERENADLKARVAQLARQQRCLEEAESKHNESIFALQGRYEEEMRSVVEQLSRTENTLRAEKTRVLSQLDASVKDKQDMERYHGEQMQTLEDKFQLKIRELQLIHEEELRTLQEHYTQNLRCLQETLNYYQRQHPGGLPALEHRSWPSARPDGAGQMTEVEADSTTGLRERIQELEAQMNVMREELEHKDLEGNASTLREKYQKDFENLKATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKTQRSQISSVNSDIEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLMGEGGGEAAGSPLTQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIVKAKADCDISRLKEQLKAATEALGEKSPENTTVSGYDIMKSKSNPDFLKKDRSSVSRQLRNIRSKSLKEGLTVQERLKLFESRDLKKN
The following text describes a protein:
Function:
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Sequence:
MTSPGTRADADAEDLDVEEALALVRETPGHGSHDNGSHGSHGRRDSHGGHGAPAPHHPADAHHQTTPWPEARATAERAARTAARAARRTPVAVPLDAALGLTLAAPLAALTDLPSFDTSAMDGWAVAGPGPWAVRDEGVLAGHAAPAPLIDGEAVRIATGARIPPDTTAVLRTEHGRSDERGRLHPTREVVHGQDIRPRGQECRSGDQLLPVGTLATPAVLGLAAAAGYDTLTAVPRPRVDVLVLGDELLTQGLPHDGLIRDALGPMLPPWLRALGAEVRTVRRIGDDAKALHRAVTTSEADLIVTTGGTAAGPVDHVHPTLRRIGAELLVDGVKARPGHPMLLARLKDDQHLVGLPGNPLAAVSGLLTLAEPLLRTLAARPAPEPYTLPLRDAVHGHPHDTRLVPVVLRGEGAVPLRYNGPAMLRGIAAADALAVVPPGGARSGQEAELLDLPWATGGIGVCFT
The following text describes a protein:
Function:
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels.
Domain:
The transmembrane domain is necessary for interaction with KCNMA1.
Sequence:
MRGSFFSRLPPQLSLLLLLSLRRVWTQEDIGTAPSKSPVAPECPEACSCSLGGKANCSALALPAVPADLSWQVRSLLLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSLAGNRLALLEPSILGPLPLLRVLSLQDNSLSAIEAGLLNNLPALDVLRLHGNPWTCNCALRPLCTWLRKHPRPASETETLLCVSPRLQTLSLLTAFPDAAFKQCTQSLAARDLAVVYALGPVSFLASLAICLALGSVLTACGARRRRRRRTTVRHLLRRQLDPEGPPSLEDAGSPVTAAIQA