lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in intestinal cells of the embryo, and also promotes the trafficking of embryonic intestinal gut granules away from lysosomes. The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes. Plays a role in the degradation of apoptotic cells during programmed cell death.
Subcellular Localization:
Cytoplasm. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MIKNTAKNKNGIITRATIDLKKDLKFVKLTAVSNLAVQNGEMLAAVTEKLLVHYSEGTGERHQEMSLPLNGPDHVAYIHLSRTGFHAIVSSKLGHNFYIHLKSNAFHHLKKLRCVVTAVGWNPDYSKETDTTGPILLGTAQGSIIELNVGSTGMMTTLKELTSQVAQIAEQRITSAPSPAAAITDIQLFQLADDDPKNKKWMVIIAQMARLIVLITDNEPAPVVKLGGFTSSASLQAGLMNLATEQAPSTTFHSFFTSPNTLQHTISSSKFSEKFKNHGFLTMHPTIAEPKRYAWLSPDGISIGNVNIYAERIQDVLVEEFNIEHRLIEGRLEPPTGIALTDYHVLLAYSSRVLALSLLPPHDVIFEDPWNPELGGALGFVSDNVAEFVWLYTQTFAMKYGTNDEARYIWKTYLDRGEYQKALQIARTRVAIEPDALEMVLRKQADFYIQEKNFTAAAEILAQSSEPFESVVLKFLTNSSERKMGLKTLLDKKLERLTRHEDKIRRDALVMWLLNVQLEELAEMRRLKNSNPDPAFVEKLRDTTDHVQRYFMRKNVIESIQTNRDAVYRMCVAHADFEMQLFFANAVKDLRTVIDILMLREQYFEVLEVLKNQRISELTYEMCPLLIEHIPKQVIVYLIQNQDQISPQKLTPCLSLCVKNMEMAIPAIKYLEAQFKGTQTISQNPQNLANLHNIYIHLMAKFRREKLLGYLESHGTIRSDLPYELDFAMRTCEQFKIEPCVVYLFCVAGMFGDAVEKALGFDVDLAKKCALMMEEAEANFAWLEGMEDPAATSYIRQKLDEKAKKAIWLKIGQYYVTQENNVDKCIELINESNHLLTIQDLLPIIPKFTRVGALKPIIVDFLKRNKQRLEKLERSMKEATEIASEIRDKQEKLKNRTTVVKPSDVCSHCARPISGRAFNVHSCRHFFHRECLEIAMISFLSQEEVEKMKTLIIDEERVLSQMKAEQLAGNQKGFIEKQEKYLKIAAFISNIVGAECPLCGNIAISQIDKQFLSDEEFAADLNTWLL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADEEAERDHSPQIGTSAAIVALRERLQKLATELKDSRESAVQSAAQYCQDFCQTLVEYAGRWKISEDPLPLVEVYMVAILSYAQARHYLTSECENVSLVLERLTLSCVELLLSLPEEIPNALWQEFQFSVQKAHSLLLDSGNCELHMLSSIAKERGVWANDTLQSILSKETPEVEKVREFLEQEGAVLLDMRVKHLIKENHIEKAALVAKVCAEHPEFGAKSSFKQTYLVCLCSVAPREQVMQEISEVDCKDALEMICNLESEGDEKGALSLCSAFLTRQLLQGDMYCAWELTLFWSKLLQRLERSTQVFLDHCRQMSLLSKTVYHIFFLIKVIQSEVQDVGLPVCIELCVRALRLETGDNANIKATICKTISCLLPNDLEVKRACQLTEFLLEPTVDSYYAVETLYNEPDQKFEEENLPVPNSLRCELLLVFKTQWPFDPEFWDWKTLKRHCLALMGEEASIVSSIDELNDCEVLDQLEDEDGTKGPEEFKDLTDCFLDTTHVLNEIVDEKQKKREIKKLREKGFISARFRNWQAYMQYCVLCDKEFLGHRIVRHAQKHVKDGVYSCPICAESFDCKELFVPHVTSHVKQSCKERLAAMKTSRKLGSPTKMPFPNCVPQKVKTNEMQDSKPKKKSRPCSNDAEVSKNSYKYTEEYTCPVTNCRKGFKYFKNLIAHVKAHKNNEEAKRFLEMQSKKVVCQYCRRQFVSVTHLNDHLQMHCGAKPYICIQLNCKSSFLSNAELLVHRKEHTAFKAKCMFPNCGRIFYEAYMLYDHEAQHYNTFTCKLPNCGKIFHSQAQLDVHQEDHNASVESSSFNLPNETLQPGIRQIKIENTVQNIQDFSQALMCDSSQNLSKEANEANTEHLNDSLPNQTPNWFHLNQSPDATQTPLLHPNIYPLELSLLEAKTKEEPVCSSSCTENSTPYFQQALPVNEACDNGRIAVNSDHTELEPLEQPESLLKSGPNEINESTQDTLSSSLQQIPNNVSAVKTEGVVQRFNCTFETCTRNYSSTRSVSKHMKAAHPEYYAELKLARKNKKVVRTPIKNVSSDGKLVFLIPSAKKGKIPVSQINTTNTMLPFTSTVANPAFTSLAANITSQVLPTQIENIINPIMLSHLGNPQNQSIPLQSKIEANPLLLSQNENTPNLTLQTESPAKLLPLHLQVLASQLSSQMNKSVVPQMHNRGGQVLDSPPDGNVEPTPTSCESSHLRYSSNVINDINSNESPQVGSMAKIALPQFNSSNPNLPSNVEELTKPLLPSAMENISHPLLPSYLESLKVPSVLSGQLEPPARANVIQHRLPSVPKSEDETLKVKRTKHNKRAKWPAIVKDGKFICSRCFREFPSPKSLGGHLSKRSHCVPFEETSMTPEFQQNPIPPSFLADLILNQQLSANLNPGMSLKDQSTNGAACDSSEVEQNNEILKQSLETATIPNLFEPSGISQQTFQNPCGCGIEKDDEKIMEIQRAFERLNLNKESNEDSHAANAVTLNNHVDAPKPVIVTKEVQSVETLIKPFVCESEGCSYSAMTKDALFKHYSKVHNYTEDMMNEIRKNQLKFAPFRCQICNKTFTRNSNLRAHCQTVHCLSQEDMIRMKIKRPYSRKSEKPPPGLLCNSGVTANKNNPLCVENVPDLSQFKKEPSEVSTVQNTFPMEENVTVKKPEYTLSSFEGNSAPSQAIGELSEDNQLSHPVQPMPEIPVARQTAEVQSPLALPVTGPLVEAQAPVLLPGAGCGPDTLKKPKLSKPKVEKPQTEKLRKTKPKERKEKKAVAKDDETVCSYSPYRPYRCVHQGCFAAFTIQQNLILHYRAVHQSELPRFDNDNEEESDEVRDEVEEEEHQIKEFRCQVKDCSRIFPEVTSLLQHYLHLHKFSLDEAGALMSNMNLGRFQCDQANCTASFTAFWKYISHIQGDHENKVLKSEGGEGLFKCDCEGCDRVYATRSNLLRHLLKKHREYHRAHLIRPRKSKSAGVKLNGKENVQNNKKPKFKRNDKRRRNSSKRAFWTKFERPTLKTNEEALAMCTKKFPLQFPCMIKGCFSVVSSERNIFRHYTTHSLTDRYIEERRGDFILCKKRSHHRYKAKSTKRDRETEKSEGTVTETSDNEDTAETCPEGSETESSKAISCKDEADENTELSDAKQSTDESSGVKPTRKRKARRKWALTVSNVLVKSKRGRPLKKRPKECTQIKEKKNEEGLKPNTFKPMGFEVSFLKFLEESSRAPKRKAKENHPDDIASKQPRTLQQKTENIICKTSETHIRTRDCQNLIDFRNPLNLTSVKNVKIVVDKTFSDGADLLLKQLQEMRPIVILKKWL
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. May be required for germline proliferation. Required for male tail development and hermaphrodite vulva formation.
Sequence:
MALMYPFHVAQPPLNWSEHLWVSEVSPAKESFITTICEHRQAQWDNQDLLRHLQDSVAILTREDQRHVNAVHAAANMPANP
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity. Plays a role in the regulation of filamentous growth and chronological longevity.
Miscellaneous:
MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium; MISCELLANEOUS: Small amount of ATG5-ATG12 conjugate is enough to perform normal autophagy.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre-autophagosomal structure (PAS). Ultimately, the IM expands to become a mature autophagosome. Also localizes to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS). Correct localization to the PAS requires ATG21.
Sequence:
MNDIKQLLWNGELNVLVSIDPSFLMKGSPREIAVLRIRVPRETYLVNYMPLIWNKIKSFLSFDPLTDSEKYFWFEHNKTPIPWNYPVGVLFDCLAGKSATFTTSFENQVKDVLTFLRIHLVMGDSLPPTIIPIASSKTQAEKFWFHQWKQVCFILNGSSKAIMSLSVNEARKFWGSVITRNFQDFIEISNKISSSRPRHIPLIIQTSRTSGTFRISQPTISMTGVNPTLKDIEGDILDVKEGINGNDVMVICQGIEIPWHMLLYDLYSKLRSFDGFLYITLVPIKGGDKASSEL
The following text describes a protein:
Function:
The PAF1 complex is a multifunctional complex. May be involved in both initiation and elongation, histone methylation and RNA processing.
Subcellular Localization:
Nucleus.
Sequence:
MNDFGEEDERQILEGTFVDKSSKQTTNDNENNNNNNNREEENENQDKNVTTKNDEDNNNDANDGDDDDDDLFGDKDLEENDNVNSDNEKNKSKKDKEDQDQEEQQEDQEDEEYSNKKKKKKSKKNKNRHSTEEDETMEDANENLDFATGAGEEEEEEEPELIRDPITLTHIETSNVLPAQKIMKLKLLNILGIQPKPFDPITFEDEEAMNGDEKSKFNVESVIRWRWGLDLNGRPAKESNTRLVTWSDGSSHLYIGNEVLEIKEQPLQNEQFYVYSSQDGFIECEGKIDSRLSIRPTNIKSKVHQRLSENVAKRTVKVSKIKSIHTTLDPEKEKEKREKELLDALREKKKQKDDSYRPNRGRGGKSGSLTASYLENDDDDYDSYRNEKGDDFVVDDDEDEEDDDYKESDDDGSDSSDDDGSESGESESDSDGDNKSKKKENKNSNDNKNNKSRKQDFDDDEDEDEDLIVSTKKVKRRVIDDDDDDED
The following text describes a protein:
Function:
Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
Sequence:
MTDLPGRRLLLVHAHPDDESINNGVTMARYAAEGAHVTLVTCTLGERGEVIPPALAHLSGAALGGHRRGELADAMRALGVDDFRLLGGPGRYADSGMLGLSDNDDPGCLWQADVDAAAALLVDVIREVRPQVLVTYDPNGGYGHPDHIQAHRIAMRAAELAAEAGCPVAKVYWNRVPRSRVEDAFARLRDDLPGLPFEKAAGVEDVPGVVDDERITTEIRGEGTAYAAAKAAAMRAHATQITVAEPYFVLSNDLAQPILTTEYYELVRGERGGEGRENDLFAGIAGTFDTGEATS
The following text describes a protein:
Function:
Epoxide hydrolase capable of hydrolyzing long or bulky lipophilic epoxides such as 9,10-epoxystearic acid and cholesterol 5,6-oxide in vitro. The physiological substrates have yet to be identified, but could be fatty acid or steroid derivatives.
Sequence:
MAELTETSPETPETTEAIRAVEAFLNALQNEDFDTVDAALGDDLVYENVGFSRIRGGRRTATLLRRMQGRVGFEVKIHRIGADGAAVLTERTDALIIGPLRVQFWVCGVFEVDDGRITLWRDYFDVYDMFKGLLRGLVALVVPSLKATL
The following text describes a protein:
Function:
Transcriptional repressor during pronephros development. Plays a role in regionalization of the pronephros; may promote formation of the distal tubule and duct over formation of the glomus and proximal tubule.
Subcellular Localization:
Nucleus.
Sequence:
MRSKARARKLAKSDNELVNNMYEPDPDLLAGESAEEETEDSIMSPIPVGPPSPFPTSEDFTPKEGSPYEAPVYIPDDIPIPPDFELRESSIPGAGLGIWAKKKIEAGERLGPYIMMQKTTLKENNLGWEQILPESDVTSQDGCLSKVSDELENDKMCLENNQNGSWNWLKFIRIACSCDEQNLEVCYLNDQLSYKVIKDIEPGEELLVYMKEGNYSPGNMPPNIDEEHTFRCEECDELFQSKLDLRRHQKYACTTVNHIYESLNDEIKQEGFDNEQMHECKDCERPFPNKYSLEQHMIIHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKSESWVPSDLHPRLPINLNCNNNTEAEEHTPKVDVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTIKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYNHGGIFAPGLPLTPSSLMDKSKPSPNLNHSSFAFNEYFPSRAHPGSLAFSPGPPPFPTLPPGFPGIFPPALYPRPPLLPPSPLLKSPLNHTREAKLPSPIGNPSIPLMSSLNSSNNNQQISIEDKFENSMENYLGKHKSRSSDLSDGSDFEDVNTTSGTDLDTTTGTGSDLDSDVDSERGKNKEKSKPMENKQDVVSSSVSRNSNNNLGERPFFYSQHSFFPPPEEQLLPSIGAANDSIKAIASIAEKYFGPGFMGMQEKKMGALPYHSMFPFQFLPNFPHSLYPAFTDRTMNHNLLVKAEPKSPRDLQKVGSTSSESPFDLTTKPKEIKSALIPPRVLAPQSSGEEQPLDLSISNRSRASQNGLREIRRNHIYGERKLMMNDMLSKVPQSQLPQQPPLHYAKPSPFFMDPIYSRVEKRKVTDPVGAMKEKYLRPSPLLFHPQMSAIENMTEKLENFANLKADTGSSLQPLPHHPFNFRSSPTTLSDSILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENVPVSQHSGVITNHHGTSVSSPNSESENHALLDEKEDSYFSEIRNFIANSELTQTASLAEKRTEIQDVDSSKCLSLVNQKTDDVDEEEDDDLEEDYEDGSLTGKSQDETVSPSMENQETYEEDEEDEEPTSLTMSFDHTRRCIEEEDAGLLDMEQIPNFGKGLDLRKTAEEAFEVKDVFNSTLDSETLKETLYRQAKNQAYAMMLSLSENTSLHTSSHNSLDAWLNMAGATPESGTFNSINHL
The following text describes a protein:
Function:
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MREKLFWILKKYGVSDHIAKAFLEIPREEFLTKSYPLSYVYEDIVLVSYDDGEEYSTSSQPSLMALFMEWVGLDKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVERLGIENVIFVCGDGYYGVPEFSPYDVIFVTVGVDEVPETWFTQLKEGGRVIVPINLKLSRRQPAFLFKKKDPYLVGNYKLETRFITAGGNLGNLLERNRKLLREFPFNREILLVRSHIFVELVDLLTRRLTEIDGTFYYAGPNGVVEFLDDRMRIYGDAPEIENLLTQWESCGYRSFEYLMLHVGYNAFSHISCSI
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Sequence:
MVTIRADEISNIIRERIEQYNREVKIVNTGTVLQVGDGIARIHGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLMIQEGSSVKATGRIAQIPVSEAYLGRVINALAKPIDGRGEISASESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVTTFQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYRKRHTLIIYDDPSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKSSSSLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKSKLELAQFAELEAFAQFSSDLDKATQNQLARGQRLRELLKQSQAAPLTVEEQIMTIYTGTNGYLDSLEIGQVRKFLAELRNYLKTNKPQFQEIISSTKTFTEEAETLLKETIQEQMERFLLQEQA
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFGANLLALLSLAFFGLLRSNGVLNAGYIGFQTIHQAYDVVFLKKECICKLILNSIFFYFITFLLFPIANNILLSMQLSIKVLISKIMCCLFVFVPLVGFQAYGCYSFCDGNNPDKLRPWCKARIPLGVGFLKYFKLKQLPNFLLSSPILLIEVCSIIHYVKLQPEAFFSLGFQVAPKSDVVDRNNTRTSTVIQGMNLKLSFGKSRFTK
The following text describes a protein:
Function:
Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
Miscellaneous:
MISCELLANEOUS: The expression of the hdfR gene is negatively regulated by H-NS.
Sequence:
MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLHTVVDSTTLSRPLYAIWLQNSDKNALIRDLLKINVLDEVY
The following text describes a protein:
Function:
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
Subcellular Localization:
Nucleus.
Sequence:
MAPRKTKPATKPAAKPTPASTATTSSCPSPKSFPIPMEVDDFSFSDSELSDAQSLIEPEGFSLLSPDESSGGRSQDELPPARKKRRVAGPKERRTQHLDLTPRLGFSDYGDQEPQLNLLVNTIRNHKKIVVIAGAGISTSAGIPDFRSDDGLFKTLQKKHNLKASGKLMFDAAVYQDEALTASFQEMVRSLSEEAEKSSPTAFHHMLARLGSDNRLTRLYTQNIDGIETSMPPLATQIPLNVKAPWPRTIQLHGSLEKMVCQKCRHMSTFDRVMFDRPDAPECPECVLTNQFRMETGQRSHGIGKMRPRIVLYNEHNPDEEAITSVMNADIRSRPDALIVVGTSLKIPGVRRLVKSLCSVIRSRRNGVTMWINNEPPSGKEFEDCFDLLVKGDCEEVARLAQLKRWDDDSKPIFDECQSADVERVKNEQGPLSVVITTPKKEKVQAQTGMLTPSSSYDGDVENASTTTLSNPASKGRKLTEILKASKKDAPKTESAGVKKPAPRKRTKKEPVKNAKITTFSKVTKAQKVTPEEKSVKLEEHKAMHPLPPGAARTNAPMLPGLAKDDSKSTPSGKRGQLETISPDRIPKGMGKLLD
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MTAAEAVKEAIWLKGLVVELSLVQLESTLRCDSQSVIPLMKNQRFHERTKHIDLSSRTTSVTSLLGPGNSGKTPVKKPSIGQKKPLDTLGSSPPPSGKKQKVSGAFLDQSIEQLNDVTAVSGVNLREEEEQLFSGPKEDSRVSEASRRVVQEEEEKLILQKIPLQKKLTEIMAKCGLKNMSNDVERCLSLCVEERMRGLISSLIRLSKQRVDIEKSRHRTIVTSDVREEILSINRKAREEWEKKQADVEKLQKANEPEGSNGVDGDKEKDDGRGKSIKANKEEDDKMRTTAANVAARAAVGGDDMLSKWQLMAEQARQKREGGGDVASGSQPSKDVTRRNLSTPTRTSKDHQEAENRSQSSAKVTPGAVRRAGRNQVITQTRIARSITVKDVIAVLEREPQMSKSTLIYRLYEKARSNASAESS
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MILVLLMVILMMIFIVQSIAFITLYERHLLGSSQNRLGPTKVTFMGLAQALLDGVKLLKKEQMTPLNSSEVSFLLVPGISFVVMYLEWFTLPYFFDFISFEYSVLFFLCLIGFSVYTTLISGIVSKSKYGMIGAIRASSQSISYEIAFSLYVLCIIIHNNVFNFVSKFNLSLLIIYIPFLIMVIAELNRAPFDFSEGERELVRGFNVEFARVAFVLLFLSEYGSLIFFSVLSSAMFFKFSIFMAFSIFSLLIFIRSSYPRYRYDLMMSLFWFKLLPISLIMLCFYAVIFYY
The following text describes a protein:
Function:
May play a role during erythropoiesis through regulation of transcription factor DDIT3.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Sequence:
MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLCLFCVGFTKKRNNQIRKTSYAQHQQVHQIRKKMMEIMTREVQTNDLKEVVNKLIPDSRGRSRLPVGASCRTRSQDSGIRI
The following text describes a protein:
Function:
Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-2, cnnm-3, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MSASCLRLLTLSLFILGQCNVTAAQNGVDDEVTTVTAILDSATTAAADNSTVPTQSASNNNTSQSSKIPTIFGMRVELPADDPFGYDKHGVCSVTPEEEFKVVIYGNHLDKIHQIIWTFTNNCSEPAYVIDALNHFKVHFNHKATFHLTLKLLPEMVHAYKMCVKPKVAPGSPPLGEIYPLDDISTWLTTERPPKEYFLPLPLQIACIGFLLCLSALFSGLTLGLMSLTPQELELVIKSGAIKEQKCAAKILPVRKKGNLLLCSLLLGNVIVNSAISILMGELTTGIYALIGSTMGIVIFGEILPQSICVKKGLEVGAHTISITQLFIFLTFPIAWPVSKLLDCLLGDEYQAYDRKRLMELIKMSITDNGQVSNELKIAVGAMEIADKVVKDVMTKIEDVFMLPDTTVLNAKTVMEIVKMGYTRIPVYQYGDKNNVTDMLFVKDLALLDPDDNFTVKTVCGYHKHPVKFVMNDTPLPNLLEAFKKGEGHLAMVKRLINTDDKHDPSYVLVGVVTLEDIVEEILQAEINDEFDIVSDNVNKVKIKKEQNRDATKYFGDHEAPQTMISMQLQMVALQWLVSNERGFRQEFLDTNVLERLIRSSARRVDVSALMAMGDDAINVPRLAKVYTKDELSDKYILILEGRIQVTIGASGMMFEAGPWHHFGGEIMAKLVDGAATLGRSMSIVGTSELSARRPDLMFKPDYSAVVKEDCTYLEISVSAYINAYKASLMQRERPLNDLSDVSHNSSAHNSNLSLVEKPGPITDPSAMLVPENVRKPSVVSMDSPKILVGLGQHPVAPVAEEEEMALLDQP
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MYNLTITTSTPSLRPQNNEKKTTHKRTKDGTGDSRETWLRRLHLTLDQPTKPGPETDRIFARLLGPSITPPSSSSSLTTTIPPKEIELQLSNVPIGLSVVVFGAVCLTKILLDISISNHPKIHEEAYQELLSDIRMAKEDLRSKGISVD
The following text describes a protein:
Function:
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MGTLVHHMELLCPITDNHKDKVAFKDRIIMLNFLRENLINLPREALEDFDTAIINVGLLVYSICESKPSAVVDFLGDIQSIQALIYFLTWKSFHYNLPKIDGLGSIDTIIDHLKEFLSRYAESLSSIRSQLQKIKQQLEQHDGFGSLAMQVIAKAYVVDHLVVSSINKDILKWCLFLWFGDIIEEITLLMGSMSEEMVGFDEVVQKLRQQLSSGSSKLDVISIVGMPGLGKTTLANKLFFDQFVVSHFDVRAQCCVSQLYIRKDLFFVDTIISDKLPENELADKLRKLLMVQRIILTTRLGDVAYNVKTVSDNHFLRMFTPEESWMLLKNKIAQKCGGLPLSVVLVAGILETMEKEKHCWEQDEEIQVSKLTWLWTAESLVKSHKEKLSEDIAEYYLRRNLVMVFKKSCDGKTMTCRIHYLLLEFFKKKAKVAEDSSLSFSYNRWNLETLIVKGLGKRVTLPDTLWKMVKLRHLHIYNHDVFNKKNALREMDGLRTLSSAWYSCVEETNMVIAKIPKFQKLRCGVFSCNSCSPAFNILTEPEMIKFSWGRAGATELNLPSSLKKLRLSIGCISMTHEHFPHLKFFKLQDLSFFEWNVSSDACPCLEHLVLTRLRHLEQIPSCFEEMMTLK
The following text describes a protein:
Function:
Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection. Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. Interacts with various phosphatidylinositol phosphates, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P), phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P), and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P).
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MSNGKKIFISHSSKDQEYVDAFIQLLKKFGFRTQDIFYSSTIETGVQPGELIFDTIKRELTNQPVMLYFLSDHYYQSIPCLNEMGASWMLSDKHYPIALNNFSMKDMKGVISSERLAIAFNDKTSTNEINCLLKKLSHDTDVQAEPDFELNVEKNIQPFQNKLTQLIRQASYLKPDEKGYFETILSTHRPVYGTAKGVYDCFKLPSLIEPKSLGLDTLSEDESHWLFFFLTWGTFQEGEKVRFKLKKDKAYNNREFSDIGKCKNIYVSYLEKVE
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
Subcellular Localization:
Cytoplasm. Postsynaptic density.
Sequence:
MEVIDGCRRTDPVIVSNGYANRIFQANMEDRSADASEVCCAEHGTSSDAVPNEQEEAPRYKKLTKGNRIWNFVWRRKGSSMNKRRPRSMIVLGDTYDASDEKKPSFMNRVMPLKKLRTSKLPKDVDFRGSAVQVTCVPEEDHPAGGQGAVYRVKKLGDSQRPYRHSYGGHIEDLDSSFEDIELNISIPEIDANESKCLRDISIRLHSEDNDSNCQKIPARKSEPLNFENFKSPAITEGDNQKKCTVLPQEGKRGRSSDVWSYLKGISLTSKDNSKLLDERAETNFQNLENITDHSTSYLDFDMRCEENLSQQKKSNGATKATHFAGFVRFFTSVAEAARRLRGSSKAFSPDEKRPPRSSRSWRQDVISRKVSLVIENETANAFCTVGACLQSPDSGVWDNPSFESSVGKETTQGFKTTEVSQDIGFSALSSKSDSLNETPLSPSGPELPDDSVTVINSEEPSETAVHFAQTALTQQIQSVDSTPEKARAEGRDLPHSEDRPGKNLGASELGSPPAANGDFPVVTVALIHHPLKMTLRELEPQDVACASVVTNDMSVSLAAALELSKTELDMKDLRNPELPLQDLSRDDQELQDSSSTPEKAQVVDLPRSQRFPEKNLDTTELNSSPAANGDSSAATPLKCAAVEGVVFEQADGCFKKHRASSPVEQNPVELLGRGVRFDCDEECRPFHVTISRIVSSGLLNNGKTMSHPSQPSPRTPPFKVLVERCRSEPLSQSTPMGLDQVGGRMQHLLRRRAENELASKTLKVRRNGGRRWNLLKPGAEKLQISRLISGGSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGTSEVQNGHLDPSADCLCLGRTVQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKIIFGNIEDIYRFQMGFVRDLEKQYNNEDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTLQINERKRRLENIDKIAQWQASVLDWEGDDILDRSSELIYTGEMSWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEMHLFFAKKLEEKLRWLRAFREERKMVKEDEKIGFEISENQKRQAAMTVKKVSKQKGVSYSKSVPPAYPPPQDPLNQGQYMVTDGISQSQVFEFTEPRRSQAPFWQNFSRE
The following text describes a protein:
Function:
Cysteine protease which degrades matrix proteins such as collagen, laminin and fibronectin and thus is involved in the destruction of human tissue. Can abolish adhesion. May play an important role in pathogenicity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Extracellular side. Cytoplasmic vesicle, phagosome. Secreted. Note=During phagocytosis, localizes to phagocytic vesicles.
Sequence:
MFAFICLLAIASAIDFNTWASKNNKHFTAIEKLRRRAIFNMNAKFVDSFNKIGSFKLSVDGPFAAMTNEEYRTLLKSKRTTEENGQVKYLNIQAPESVDWRKEGKVTPIRDQAQCGSCYTFGSLAALEGRLLIEKGGDANTLDLSEEHMVQCTRDNGNNGCNGGLGSNVYDYIIEHGVAKESDYPYTGSDSTCKTNVKSFAKITGYTKVPRNNEAELKAALSQGLVDVSIDASSAKFQLYKSGAYTDTKCKNNYFALNHEVCAVGYGVVDGKECWIVRNSWGTGWGDKGYINMVIEGNTCGVATDPLYPTGVQYL
The following text describes a protein:
Function:
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. Confers resistance to some classes of antibiotics.
Miscellaneous:
MISCELLANEOUS: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
Subcellular Localization:
Cytoplasm.
Sequence:
MITAEKKKKNKFLPNFDKQSIYSLRFDEMQNWLVEQGQQKFRAKQIFEWLYQKRVDSIDEMTNLSKDLRQLLKDNFTVTTLTTVVKQESKDGTIKFLFELQDGYTIETVLMRHDYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVSQVLTVQKALDATEERVSQIVIMGIGEPFENYDEMMDFLRIVNDDNSLNIGARHITVSTSGIIPRIYDFADEDIQINFAVSLHAAKDEVRSRLMPINRAYNVEKLIEAIQYYQEKTNRRVTFEYGLFGGVNDQLEHARELAHLIKGLNCHVNLIPVNHVPERNYVKTAKNDIFKFEKELKRLGINATIRREQGSDIDAACGQLRAKERQVETR