lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
METDEENKLLKKFLLQLPIKADFDFNKNVKKEIRKALFMSISSNGEYLNWLFPSAFLDNQSYQRDDMIKKVEDDYEWTFNNYYKALLSKRDPKHDTHSHRAYHKNSPCGRIFRKGEPIHRCLTCGFDDTCALCSHCFQPEYHEGHKVHIGICQRENGGVCDCGDPEAWTQELFCPYAVDEDSTPVHDKEIPEKLAASILTTIAIILDYMIDVIIHSDLQFKNPEETTVHAIELNTANSTLDPRKYGCHDNEFVDATNNQYYLMLYNDQVRYYRDAVQRVHLASKKVKDFAIMVTDKVQKFGKAKVISSRNIPLLLERQKILSATGLATCIRSHRDIFREDMCDELVSWLNDFSESELFKTNAAVKDLFCRAFCEKWENGLLGVSEIETNYSYKVGTLDSSLRIPKIPSREQNTDGHWYYSPSKWKLCDELCQECNYNINTSEFQKNVSHHGSRLQYLVYLDIRLWKDTRALLHDMYSTSLIINLRYKNIICYQYVDIYPTIVDMYLTMDREPELSIMPTLSTQLFTCPTNSAEIIKHGDLTQILSSVYGFLTAERVTAPGDIDRTHQVSIKSLKNRRWGQIFFDLSYILTRSKNSKFLPNSNIVPMTCDMLVLFQGKPILKREKANHVEYESPDYSAFFQAVSVIYQFGEVIAGALKTTRETELCDILHNYQLAIEYVLTFLVNFENRNFPGLVDEEVDIKLSEEKAYNVEPITGSLIQISDIEEDKVSFLHPVHSFLSWLIEFSRFTDIRNLVEVFQTVKLKHIGSETPSLEVLIFDYPIKTIVLMSQIKAGLWVRNGFSVKSQLQLYKNTSLRDQGYTRDLFLIQVFANLDHPDVITYLILDRWKLLEDWLQNKPSHMYDIKTLPYMLEECLGFFIHLLTEDTHLRGYDEETLIKIKIQREIIHILCFGPLGYSKLCSQIPDHIVADRRFELILKSMTVFKAPKGSNDFGVYYLKDEYLDDVTPYYCHYTANVKDEAIKFVKERISKKKSKPVSDVIIEPKRIKTEELGIYKHVGNFATSTYFTNFLIKVLLFVNSCDTKVVESLLETILHLIHICSLEQTINIDKYGSFFDRFMNWSEEFGASIADLLYKILLAEEFKFSHTKIRSIFKIFNQKYPSFIPTLKARRSEFDISKVDLSSDDANSEDELGKKKRIAKERQAKLMAKFKKQQSSFLKKNQFETIACGSDTEMEELDDHAAWKFPEHHCMLCQNAAEDAGPFGIIAYISKSCEFRNVPFSDEYWFLKAFSDNVDLNGNEYESDINQSLHNSPHTQTWNSFMQQASNSSVIGPGFKLNEFIESHFVASSCGHGMHYQCYVNYISNSRNRQNQITRSTPENMDRKEFLCPLCKALNNIFVPILWSSNNRSLQEFLKPYAGTSPFLDLDMKIAKDRGWTERFQSFSEQEFDSRSILTGISKEMISMDSTKELTKQQRDFRLMLSDMFQTLTLFTFPQVFKADSGFVLIDTIKSIEISLRGVSSGGQLIIHQLSNNILLTLRTLNEFKNSSTLMKVKNWIDSPNLRKSAYSKIFAYIFALSKKSINNYMLEVDFFEHLVNTDTFPSLGFSFNSVLETCFIGHLIQSLSIMVNEMSANCLKKNWAYTVSDIPTIADIPQGISEAAISCFKKLSNSNDVRCIGNDESRKFGEVIYSMLVKIATPFLRRAAIYAYVQCANIDGIDFAASPETEIEADRLCSFLNLKPVCEYLRLFNEESSYEGSVFYDFLTFSSALPKANDVLRIKKQVEYPGIVKLVDLPERLDFFFTKYYYSDRHNNPNKKVEDPAICLFCGDVVDIQKQAIGCKEGQCTTHYLKECSNDVGIFLLPKDRSLLLLHKNGGTFYNAPFLDEHGEIAEESKKAKALHLMKPRYDDFIRNIWLSHNVQNCIVRSLESVLDPGGWETL
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSPIQDFYSQQTIFLTGASGFLGKLIIEKILRTCPDIQKFYILLRPKHDRALEQRFNDIFSNSCFEPLKAENKDFAKKIHILSGDCSQPMLGMSPEAQAIVKREVTCVIHAAANVRFDVDLKTAVFTNVRSVRDLMDMMKEMENLRAFVYVSTAFSHCHRDKIDEVFYDVDVKPEKLLQIMEVMDDRTLEVVTPHLLGEWPNTYVYTKAVAEELIRSYKQVLPVAIVRPAVVISTCDDPLPGWINNFQGVVGVVVGVCLGVLRTLHLNKNLPARVVPADYVVNNILAAAWNVEQTKNEPKDKLIPIYNFPGCKNNLITWNQFINKFKEFTFVYPLSDAVWYPYIQTTCYKPVHKIREFFYHTLFAYLVDSVLLVAGKRPLAVEKYRKIGKLTSLISFFTTRSWNFETTNTDRLFDKLDDKDKVMFNFDMKSFNWEKYWEKVILGGRIYLLNDPIETVPKAKKKMVLLATVHYVFVVMMVCLLYWVFAPLVKAVL
The following text describes a protein:
Function:
Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets; Stimulates aldosterone release.
Subcellular Localization:
Secreted.
Sequence:
MFPRLTTLLLLAWAASVASDRVYVHPFHLLTNNQSSCDELKNKDAMASEEQTFTPVPIQAKTSALDEMALKEQLVSFGQTLDKEDKRRANDVALLVNFVGFRMYKILRQMVTPDNGAILLSPMGLFGTLASFYLGAEDPTATQLQELLGVPGKDENCTSRLDGHKVFSALKAVQALLLAQEEKGSPSLLLTTVVGLFTSPTLRLKQSFVQGLAPFTSITYSRSLDLATNSDLAAEKINRFVTAVTGWKRSTQLIGISPDTTLLFTTYMRFQGAIKGIYKLEEPQVFWVNNTTGISVPMLSGTGTFLYWNDVENKFSVTQVPFNKNAFLLLIKPQNDDLEKLENLVLVRNFSSWMKNLSPRNIHLTLPKLALESTYDVQNLLAYTKLPGLLGKEAKLNKISDANLKVGKVMNTVLFELKESQREQDSFQQQNEAVPLEVKMDRPFLMVLYEQATKTLFFFIRVTNPLRDV
The following text describes a protein:
Function:
Modulates RecA activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPQKSLRARAMDILSRQEVSRIGLKRKLAPHAESEEELENVLNEFAERNWQSDLRYAEAYIRSKSRKHGSLRLKQALAQQGIDEKTSRNLLPDRSSEKQAAIAVLRKKFKHPAANLKEKQKQARFLAYRGFDADTVQTALKHAWDENWEDSC
The following text describes a protein:
Function:
RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, P-body.
Sequence:
MEQSQGNIANSPPTSEIPQRPIILSPPPLDQNSLNQSFNNLPTSVPQGHANRQQSVGYNLQHEFETLTANLDLDLNSSTRNITQSAPPNQQQQQQSQLQATDSQLLTTTADLNTKPAHSVKPTLAAPAASRYGSHLGSDLLGKSTSSLLGDNNPVSPIQKFSSINTQLDSLLNNNISSAKSKTGTNSPFLSNAGLSNRPQSVNDFSNIFNRQDQQQQQQSQTFSSFTTQQQSQNQNQNQNQSNFYSDLIVFSNWIENLNPQDNLTMIDYLCSNLPLDILLTFKSKLDLHLQGGSAQNQQSQQSQLLPQFVMSPYSQYDQQLYNDMDKLNIQDDSFKSKHGNSSFRSNHLANLIDKVERPKSADPFVNNTKYGQYQQQSYNQHSYQQQHPLVDRAKSPTSHLYEKTNFLQLAAANSNNTGGNYNQYMPSLSSTSSSLGQANSNNTSTRDDMDLKLGALATINSRVALDSNRKHPHVATPGSTWNNQTHTHSHISPPHHNQMHSGVRNVSNFEESINRSLNSSSVPASMHKSNYSNSHGNNSNNNSGNTNINSNQNKGTHKKKINSPTSAVSMQQNSTSVNSTTSGNGGANANVNTTATTSSSSSSSMPIEVSSLELLNNIPAWLKLLRLHKYTECLKDVPWKELIELDNDQLESKGVAALGARRKLLKAFDVVKNNLPVV
The following text describes a protein:
Function:
The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
Domain:
There are three Gb3-binding sites in each subunit B monomer, allowing for a tighter binding to the target cell. Binding sites 1 and 2 have higher binding affinities than site 3 (By similarity).
Sequence:
MKKTLLIAASLSFFSASALATPDCVTGKVEYTKYNDDDTFTVKVGDKELFTNRWNLQSLLLSAQITGMTVTIKTNACHNGGGFSEVIFR
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MYSLCRMVTSSTLRRGALVAGKEARSDNAILDARVVQHVFKNPEVKRDYSNRKGFLENFIETIKQEYNKDPELKESIKKFRQEAKELEDSDALKQARKKFQEIEKETTQSTEVLQETFGKIKSKVSETAEELGSSEVGKAASRISGGISDAAKRASESEALKKVQSRLSDIAQGSGVAPDSLYRPPTVLRMRKQELSVDPDREYQPNTEATNIVMHKDTIWNQQWESFKTSKVGESISEMKMRFDESDNVLIRGSRFITDKISGVAGSLFGGTDISKVMTEIARIDPEFSAQGFLDFCRFEIIPNLLEAISQGNENIVKDWCSEAPYNQLMFPVKQAQQIGCRYELTTVDLDHVDIAGATKVDQGPVLVISFQTQQIMVVRNKKGDIVEGDSDQIMKVFHVWALCRDVEEMDRRAAWKIIDQSMSASPMLL
The following text describes a protein:
Function:
Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MVKCSVLTLFLFYNCFFFFLCFPPSNFIFTAFYLSLPRCPFPSFSPLSAHAHSARRGESAWWRRGSIQRKRNNGKRRAAEELEEDGQRDAESSTPLANMKVYKEVIRDDIVPLSARHHDRNTSEPISFFLSNLEELFSWKPTNQDAFNVAVVPVAKRHPPIESQRPKTLVCHDMMGGYLDDRFIQGSGAQQPYVFYHWQHIDIFVYFSHHMFTLPPVCWTNAAHKHGVCVLGTFITEWDNGAKMCESFLAGEESTYHAVADQMVRLAEYYKFDGWLINIENVLSPVAVSNMLLFLTYLKEQLHKRIPGGMVLWYDSIIHEGELKWQNELNDKNRNFFDVCDGIFTNYNWTEEHLQRMTEEPRRTDIYVGVDIFARGEVVGGKFDTVKSLEMIRQYGLSAALFAPGWVYECLEKEQFLQNQDKFWSLLESQLPIHSLCLLPICSSFCLGYGKKRYSFGEEEDSGPWFNLSAQEVQPIFSEVQPKDGKGGRVKSQICQEVAWHGGSSLLIEGSLPSGIDGVTVRLFSLHVPAPPKLLLALVYKMENSSNVAVSLELSTQDAKSCNVDSINALSVESMVQTLQPLTEPPLPVAETQQNHKHGWEQRYYEVHLSDCYINSLSMRFSQLTPQEEEETFTCRIGEIRVLDFSHPPSLPVQPTDLSLSHVRWLQNEETNQLFVSLTLHWSHSMENIRHFRVFCRGVTCRLPPPSRPPPPSRPHLLGLAHACVYRVVDLEVPDPCPSSHGQIEFAVQPISKEGFEPVPPLWGQLVLDYVKETQTEV
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
Sequence:
MCRHVAWLGAPRSLADLVLDPPQGLLVQSYAPRRQKHGLMNADGWGAGFFDDEGVARRWRSDKPLWGDASFASVAPALRSRCVLAAVRSATIGMPIEPSASAPFSDGQWLLSHNGLVDRGVLPLTGAAESTVDSAIVAALIFSRGLDALGATIAEVGELDPNARLNILAANGSRLLATTWGDTLSVLHRPDGVVLASEPYDDDPGWSDIPDRHLVDVRDAHVVVTPL
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MELLPARRAASADPKAEDGEGVELTLGLAIGGSTRKTPEPRKEAEGPRKGGIFDLPDGASADDRAAMDAQMLRSRARDRAVREEEALSGDRSRPSRTDGGNGVRWPRVAPVSTPNPNAHPNPFGFGQHHPFPVMYPHQQVQYVPVPNGFGFPFVMPCWAPTISAVAGGLNRLERKVYQPLSGRGFPVQGTAAGPCDGDSSGSKGIEAAKVVNTSLNSDSSGSSSSAISDRRSGSFGGGSISSGDSRSHRSLQKAEKPAAPPSAEGGSGNNALTSCLTSNAKPARFGAQPERAGSVNKSGKPSALPRMPLVSATGDAPHGRTIHGLLYRCTKSEVRILCVCHGNSFTPVEFVRHAGGADVSQPLKRIVVVQPGW
The following text describes a protein:
Function:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus (By similarity).
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGAGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATARTDRETKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFSPRGPRPVQSVVPELEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKAEGDAE
The following text describes a protein:
Function:
Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
Subcellular Localization:
Secreted.
Sequence:
MKLSVLSVLLVSVAQAAAAPWRPREPRAAGSKRLTFNETVISAALSPSSISVQWIATENDGDYVYQEEDGSIKIESIVTNRSQTIVPAEKIPADAYSYWISPDLSAVLWATNYTKQYRHSFFADYYIQDVETLETVPLVEDMVGDIQYAEWSPSGDSIAFVRGNNLWTWSDGTVTAITKDGGPDMFHGVPDWIYEEEILGDRFALWFSPDSELLAFLTFNETGVPTFTVQYFMDNQEIAPPYPRELDIRYPKVSETNPTVKLNILQLSDNTVSTIPIDVFDPSELIVGEVAWVTDTHTELAVKAFNRVQDESKVVIVETASGETKIAHERDGTDGWLDNLLSISYVGPLALGSGDASSAYYVDLSDHSGWTHLYLFSTSGGDPIPLTEGEWEVTSIVSIDQERELVYYLSTQHHSTERHLYSVSYRTFEITPLVDDTVEAYWSVSFSAKAGYYILTYAGPSVPYQELYSVNQTAPLRTLTSNAALIEKLEEYALPNISYFELEIPSGEKLNVMQRLPVGFSPDKKYPVLFTPYGGPGAQEVSKRWQSLDFNAYIASDPELEYVTWTVDNRGTGYRGREFRSLVAKQLGKLEAEDQVYAAKQAAKLDWVDSEHIAIWGWSYGGYLTGKVLETDSGAFSLGLLTAPVSDWRLYDSMYTERYMKTLSTNAEGYNTTAIRHTDGFKNVEGGFLIQHGTGDDNVHFQNAAALGDTLIGNGVTPEKMQVQWFTDSDHSIRYNGGNVFLYRQLAQRLYKEKNRAKKEQHQWSKRSQDWVV
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDCLVAYYTERFKTVDGNVFEEFAKFYEKDLTRVHSWLESQFKKKTVKNNAISALHRREGNNFYAEKNLIKSFDCYTKSLRFAIPYSKEYGLALANRSAVSFELKEYHNCLKDIELCFKSDYPTDLKPKVYVRKTECYYELNQKEALNQCISEVLHFLETENVVEKGKFVTRLNHIKKLKNAKPKTDSGQECLHEIPVFPDGENKCLAYASTKVKMSYNKDKGRHIIASTNIQRGDLLFIEKAFVFAPVFKENKEFYSFKCYNCLSDIVSGVPCNTCTVCVYCDEKCRDQNWTKCHRWECDGMQANIWFDLGIALPAFKVMLEGALSGFQTLEGGFEDDVKHFGDKENNYRYFNRLLSNIHKNKNLAPYIIMASVVTTYLQKYTDFFTWFLTQPSCPKEGLNELVKLVGGFITKHIAQLACNSSTIEQWTCSSSDLLFPDVLITIASGIFPSVSIMNHSCRPNVTNYFMSDTIVVKALEDIAQNEEIFNCYGIDYRGMEREQRQYACKELYHFECKCVICSDPAHELDMLDSYLCPKCKGLVPEIKNTILSFCVNCGEKYHLKPFRKINYEAQKYMESDSSNQLELLIKSLKIREKILYKHHKDFEEVYYRLYSFYVKLGDAENMFKYFHLWLENEKARRGCNSRVVGTKLYEAALAILHCLKGGQQKNCTNLKDFLQNVEYMIKEAKAILNLYYPAFITNRLNKKIQFISTK
The following text describes a protein:
Function:
Involved in the regulation of sugars and amino acids metabolisms during the night period.
Subcellular Localization:
Mitochondrion.
Sequence:
MSNFSNQIRASSSLIKRLKQRMTNPAALMQATRHFTTLEGHRPTIVHKRSLDILHDPWFNKGTAFSMTERDRLDLRGLLPPNVMTSEQQIQRFAADLKRLEVQARDGPSDPYALAKWRILNRLHDRNETMYYQVLIANIEEYAPIVYTPTVGLVCQNYSGLFRRPRGMYFSAEDRGEMMSMVYNWPAEQVDMIVVTDGSRILGLGDLGVQGIGIAIGKLDLYVAAAGINPQRVLPVMIDVGTNNEKLLKDPLYLGLQENRLDGDEYIAVIDEFMEAVFTRWPHVIVQFEDFQSKWAFKLLQRYRNTYRMFNDDVQGTAGVAIAGLLGAVRAQGRPMIDFPKQKIVVAGAGSAGIGVLNAARKTMARMLGNNESAFESAGRQFWVVDAKGLITEERENIDPEALPFARKVKEASRQGLREGASLAEVVREVKPDVLLGLSAVGGLFSNEVLEALKGSTSTRPAIFAMSNPTKNAECTPEEAFSIVGDNILFASGSPFQDVDLGNGHIGHCNQGNNMYLFPGIGLGTLLSGSRIISDGMLQAAAECLAEYMAEEEVLNGIIYPSTSRIRDITKEVAAAVVKEAIKEDLAEGYREMDARELQKLSQEEIVEYVKNNMWSPDYPTLVYKRD
The following text describes a protein:
Function:
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.
Domain:
The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.
Sequence:
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQVPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLVSIGSSYNYGNEDQAEFLCVVSKELHNTPYGTASEPSEKAKILQERGSRM
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSFVITVIVVYVSSFWWMTPFITYITRAHVSLHAFSFTEMIQIYVMIIFFIAFCFISPVMFYQLWAFIAPGLHNNERQFIYKYSFFSVLLFCAGVAFAFYVGFPMIIQFALKLSLTLNISPVIGFKAYLIELIRWLFTFGLLFQLPILFMGLAKFGLIDTTSLKHYRKYIYFACFVLASIIAPPDLTLNILLTLPLILLFEFSMFIVKFTCRGKPPTH
The following text describes a protein:
Function:
Functions in mitochondrial division. Functions in peroxisomal division (By similarity). Mediates membrane fission, perhaps mainly of the mitochondrial outer membrane. Mitochondrial fission may be promoted by recruitment to mitochondrial membranes via the egl-1/ced-9 complex. Involved in the coordination of mitochondrial division with autophagy in response to acute heat stress during larval development. Plays a role in apoptosis by promoting mitochondrial elimination and cell-death execution, acting downstream of caspase ced-3, and perhaps independently of FIS1-related protein fis-2, caspase ced-9 and apoptosis-inducing factor AIFM/wah-1. Role in promoting apoptosis dependent upon cleavage of drp-1 by ced-3. Involved in negatively modulating longevity in concert with the Insulin/IGF-1-like signaling (IIS) mediated pathway.
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane. Cytoplasm, cytosol. Note=Localized to sites of mitochondrial scission. May be recruited to the mitochondrial surface by a ced-9/egl-1 complex.
Sequence:
MENLIPVVNKLQDVFATLGRKEDQIQLPQIVVVGSQSAGKSSVLENLVGRDFLPRGTGIVTRRPLILQLNHVALDDESKRRRSNGTLLTDDWAMFEHTGSKVFTDFDAVRKEIEDETDRVTGVNKGISLLPISLKIYSHRVVSLSLVDLPGITKIPVGDQPVNIEEQIREMILLYISNPSSIILAVTPANQDFATSEPIKLAREVDAGGQRTLAVLTKLDLMDQGTDAMDVLMGKVIPVKLGIIGVVNRSQQNILDNKLIVDAVKDEQSFMQKKYPTLASRNGTPYLAKRLNMLLMHHIRNCLPALKARVSIMNAQCQSDLVAFGEPVEDKNRTLLQIITRFATAYTSTIEGTARNIETTELCGGARICYIFHDTFGRSLESVNPLENLTQLDILTAIRNATGPRPALFVPEVSFELLVKRQIQRLEEPSLRCVELVHEEMQRMVQHCGFTTQQEMIRFPRLYDKINEVVSGVLKERLKPTNELVENLVAIELAYINTKHPEFTEANLVTLLKEELLLDDRHGRSRNRHASTGERAVSAHGEQQLQPVPGVNGVDLNAVLQQQQQQSQNQRASNGFLGLFGNAAASSKTSPQEKQSANFLPEVPETQLGRKLTSREQRDVAIIERLIRNYFIIVRKNIQDSVPKAIMALLVNFVRDNLQSELVRQLYKPDEMDDLLAETEDMAQRRRDTLETMKALQQASVIISEVRETQVW
The following text describes a protein:
Function:
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex.
Subcellular Localization:
Membrane.
Sequence:
MSTNNMSDPRRPNKVLRYKPPPSECNPALDDPTPDYMNLLGMIFSMCGLMLKALNLRRGDVLSAESSAHDAPMVMPPRKLCSQTPAHRRLSGLAFGCLHPPSAAVLNLSECGLWAPS
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular Localization:
Cytoplasm.
Sequence:
MCVHCSADQHGSRFIQQKLETATAEDKAMVFQEVFPQAVALMTDVFGNYVIQKFFEHGTAQQRKELAQQLPSRVLTLSLQMYGCRVIQKALEVVDVDQQTQLVSELDGHVMRCVRDQNGNHVIQKCIECVPPDRIQFIICAFYGQVLALSTHPYGCRVIQRVLEHCTDEQKQQGIMQEILRSTCSLAQDQYGNYVVQHVLEHGTQPERSEIITKLAGQIVQMSQHKFASNVIEKCLQFGGPAERQILINEMLGSTDENEALQAMMKDQFANYVVQKVLEICDDRQREILLTRIKVHLHALKKYTYGKHIVARVEKLVAAGGTSV
The following text describes a protein:
Function:
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Sequence:
MPDRSLRLFFALPCPPPLAERIGRWRDDRPLPGRQVATANLHLTLAFLGQVPSARLEALLDMAAAIEAAPFDLYLDRLLRWRNGILLLAPSQPPGALLRLRRALRSGLAELELPVETRSFSAHLTLARDAAPLEDAPLPPTFVWQVDHFSLFCSQNDAAGVRYRTLRRWALCGEDSNERFAP
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDNYSPSALVRILHSFPHLTFKFVLLQNPAFTVDSSEYLESLAILALMPIVILLLTMIGFLFYYCCVAVKRATPNKNNSSACYCSVCMMTTFIMLTLGGVSVGIYGSIQCNEGMRSAIQSTNEINQSFSTITDDVQDISMLLSEINAQTNQLFAVEIDTSGTLSVQESLSEMSDKLDFNLQQTEGANDRVEWTIELLRVVENYRTIITFSLLGVIGLVCLLGLAGVCFRSKCLLVTTTFIGLMCLVICYIYIGCDFMVDVAVGDLCMDPYTYVRDQAVSKLYMNEATANYYLNCSQEIGSVDPFASVVEEALDVVQQFSSLIESYDTNQE
The following text describes a protein:
Function:
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
Miscellaneous:
MISCELLANEOUS: Present with 2250 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MERPSFLDQEPPAGYVPGIGRGATGFSTKEKQVVSNDDKGRRIPKRYRENLNNHLQSQPKDDEDDEAANVFKTLELKLAQKKKKRANEKDDDNSVDSSNVKRQFADLKESLAAVTESEWMDIPDATDFTRRNKRNRIQEQLNRKTYAAPDSLIPGNVDLNKLTEEREKLLQSQIDENLAQLTKNASNPIQVNKPNAATDALSYLKDLENDRVNSLSDATLEDLQKMRTILKSYRKADPTNPQGWIASARLEEKARKFSVAKKIIENGCQECPRSSDIWLENIRLHESDVHYCKTLVATAINFNPTSPLLWFKAIDLESTTVNKYRVVRKALQEIPRDEGLWKLAVSFEADKAQVIKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTLNSFRKILPQEPEIWIISTLLEERNNPDIPVDKLVSLLKEGLLELSKNGYKATLSAWLKRAEALNDAPNSNLTCQAIVYAILEWLRESGEYESELNNVDQILEKMPHSKVQIAVLKKLIQWDPCDTVLWSRLKMATESYHKIEELLAFFQELLFQTKNSDDIRANMREKSPGLLMMYVSEYWKAQKGDTRQTLVLIDQIIDFAPHNLDLRFFKIKLLGRSLQLDELRDFFQQTFSSLEDFKISGTERLYYKYVNFLRYQDLNEEAIKFLNERCLKSFPICHKFFLQLGQIYHSMGNIEMSRETYLSGTRLVPNCPLLWVSLSKIDEIDLKNPVRARSILDRGLLKNPDDVLFYIAKIQMEIRLGNLDQAELLVTQALQKFPSNALLWVEQIKLFKHGNKSSLKKTIFQDALRRTQNDHRVLLEIGVSFYAEAQYETSLKWLERALKKCSRYGDTWVWLFRTYARLGKDTVDLYNMFDQCEPTYGPEWIAASKNVKMQYCTPREILLRLMNDK
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MAMAVFRREGRRLLPSIAARPIAPIRSPLSSDQEEGPLGVRSISTQVVRNRMKSVKNIQKITKAMKMVAASKLRAVQGRAENSRGLWQPFTALLGDNPSIDVKKSVVVTLSSDKGLCGGINSTVVKVSRALYKLNAGPEKDVKFVIVGEKAKAIMFRDSKNDISLTVTELNKNPLNYAQVSVLADDILKNVEFDALRIVYNKFHSVVAFLPTVATVLSPEIIEKESEVGGKLGELDSYEIEGGETKGEILQNLAEFQFSCVMFNAVLENACSEMGARMSAMDSSSRNAGEMLDRLTINYNRTRQASITTELIEIISGASALEAAK
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATEPKAATEDVKIDLFEDDDEFEEFEINEEWDDKEEGKEVTQQWEDDWDDDDVSDDFSLQLRRELESNTEKN
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPPLKSALPLQIIKHRPFASSLTAVVFFWGWVIGTAVTFPVGVILDLETESGMVWNTTIAMAVEDFYASHRDYKTRLVLNVRDTKQDVFGSAVSVVDLLGNFGVQAIIGPTDSSQARIVSELGNRAQVPIISFSASNPSLSHANTPYFIRTGLDDSSQVNVIADIINHFRWSEVVPIYEDSEYGNGIIPFLYEALSSVDAKISCRGSGSIPPTATDDQIYSTLKVLKSHEARVFVVHMRPSLGWRLFKKASEIGMMEDGYVWIITDGISSALNLADPSTVPLDSMQGVLGVKPYVQTSEALRNFTSRWKTRIRKDRDLNSDASLDVHALWAYDTVWALAMAVEKVVESSTSTSTSTKDHFGKSIDYSNLGMLKAFSLGPELVDAIVATEFSGLSGKFHLVDGQLQSSPFQIVNVNGWAPGREVGFWKSSSGLSRRLSVSAENMINTNVLGPVIWPGEAKLIGGDGRRMLSPVEKNKRKITVIVPMKNGFNEFVKVESIDNRTKEVNVSGFSIDVFKQVIKNLNVDIVKYEAYSIYENHNYDDMCKELKKDSVIVGDVTIIARRSYVEFSLPFTETGIAMLVPTSKNSYAESGSPWILFKPWKWDLWLTVFGFLLLTALMVWVIEHRINPEFRGPPSQQMSLVFYLVFSTLVFPQKEMVISNLSRIAYIVWVVVIFILTTSYTASLTSMLTVENLQRPRITDLVSLLDNGDYVGYQCGAFLNNTLHDFGFSKSKIKCYNTSEEYNIALSLGSSGGGVSAVLDEVPYINLFLNKHSSNYTMVVQTHKGFGMSNTQQTSGYGFGFVFPKGDPLVLDVSRGVLEVTQGTTIDAIDEKWFGARKMSNEEDHDYIQLSFHNFWGLFVITGGASVIAIIVYLINFACSNWGEIKDVVFSDSSIKTKISMTATMFDKKDSKFKAVENDSRHTNSSDECCGSMIVDQTSASSSEYHLSATPKITRFLSLN
The following text describes a protein:
Function:
Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.
Sequence:
MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRYYTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALEQTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIESADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYACIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRIAE
The following text describes a protein:
Function:
Fatty acid 2-hydroxylase involved in the alpha-hydroxylation of the long-chain fatty acid (LCFA) palmitic acid. Probably involved in the resistance response to oxidative stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVAERYTVDLNKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFESDFWEFLTRTVWWAIPTIWLPVVCYVLSISASKGLTFPQIGLIVAFGVLTWTLLEYTLHRFLFHIQTKSYWANTAHYLLHGCHHKHPQDGLRLVFPPTATAILLVPLWKLLHLLATPATAPAILGGILFGYVMYDITHYYLHHGQPKEPTFKHLKKYHLNHHFRIQDKGYGITSSLWDKVFGTLPGIKAAAKKS