lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
Sequence:
MRILHTSDWHLGKNLEGFSRMDEQERFIEDFINIVDKNNIDMVIIAGDIYDNGNPPARAEKMFYDCIKKISNKGERLVLIIAGNHDNPERLVAASSLAYDEGIILMGTPKTIVPKGKYGNFKVINSDLACLEIGVKEEKAVIISLPYPSEKRLNEILSKEMDNDEDRRKTYSERIGDIFSNLQEKYYKDNTVNLAISHIFVNGSEETDSERPIQLGGSLSVDVDKLPKKAQYIGLGHLHKPQKVRGIDNAYYSGSPLPYSKSERGYSKGCKIIDVHPGEKAVIEEVYFNNYKPIEVWHCNGIKEAINKCEENKEKDMWLYLHIKTKEYISTEDIKALKEIKKDIVEIVPEIEEKREETFNGNIKEKSMAELFKSFYLNQRGIEASEELMDLFLSIAQEEDEYETEETCD
The following text describes a protein:
Function:
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Sequence:
MSGTEEAIFGERDSHTAAHGSLVCFGQCQYTAEEYQAIQKAPRQRLGPEYISRGQKVCYIEGHWVINLANDMFGYNGRAHSITQQNVDFVDLNNGKFYMGVCAFVRDGSYHEVVGYGSKASSLEKARKEAVTDGLKQAPRSFRNALGNCILDRDYLRSLNKLPRQLPLERQDFEPSVEEARYNSCQLNMALGYPQLQDVTSPCRSSHVVIQGDKDCSFPTSEEATYQQKFWQKELQQQFWEQMEKQQIHTFSPSVEKSEETLGDNSEMWDVTPDAGDGVVKEEPPQTSDTPALNKMVTQNRTPHSLYLQTYSTDQCITGNWESHRKGQDMKKRKLDPS
The following text describes a protein:
Function:
Plant-specific TFIIB-related protein that may be involved in an intracellular signaling pathway between plastids and the nucleus. May act as general transcription factor (GTF) of RNA polymerase I-dependent transcription and rRNA synthesis. Forms a ternary complex with TBP2 and the rDNA promoter region.
Subcellular Localization:
Plastid, chloroplast outer membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Localizes to the nucleus under conditions of proteasome inhibition.
Sequence:
MKCPYCSSAQGRCTTTSSGRSITECSSCGRVMEERQTQNHHLFHLRAQDTPLCLVTSDLQTAAQPSPEDEEDPFEPTGFITAFSTWSLEPSPIFARSSLSFSGHLAELERTLELASSTSNSNSSTVVVDNLRAYMQIIDVASILGLDCDISEHAFQLFRDCCSATCLRNRSVEALATACLVQAIREAQEPRTLQEISIAANVQQKEIGKYIKILGEALQLSQPINSNSISVHMPRFCTLLQLNKSAQELATHIGEVVINKCFCTRRNPISISAAAIYLACQLEDKRKTQAEICKITGLTEVTLRKVYKELLENWDDLLPSNYTPAVPPEKAFPTTTISTTRSTTPRAVDPPEPSFVEKDKPSAKPIETFDHTYQQPKGKEDKQPKFRQPWLFGTASVMNPAEMISEPAKPNAMDYEKQQLDKQQQQQLGDKETLPIYLRDHNPFPSNPSPSTGISTINWSFRPSVVPGSSSNLPVIHPPKLPPGYAEIRGSGSRNADNPHGDF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSNIIQLLTGEVALRTDHVSIYFSLDEWDYIKGNKDLYEEGMKEEPQQLQSLGCEYDEKSNAKANVAEEAAFLTDWNPPHTDTLPAELIGPQCGIKKGPTLCEGENQPDCSINPLTEQIQETDTPTPIMGCSLNNRSDINHNVFGKNVYINTPHASHLFKHPSEVIYNCTSCIKRFGNSYDFVRHLRTHTGVKPFSCSDCGKSFTRRSNLNVHCRTHSGNIPQSQQHTAANGVKDAAGLYDGANQSDCSFNALMEQTWGSDTPTPILGCSLNNNFSGNYISVASNKERLSSKPRNQSDCSFNILPEQIRETDTPPVMGGSKKISLSSKYISVSIKEETASCEEGNQSDCSINPLTEQIQVTDTPIPVFECSQEDGLPAIKLSDYNENIKSSPLTSQLPNRAIQMLYTCTECHKHFTKNDDLIRHQRTHSGEKPFSCSECGKCFTRRSNLNAHFRIHTGEKPFICSDCGKCFTRSSLLIIHKRTHTGEKPFTCSDCGKCFTNHSDLKIHHRIHTGEKPFTCNECGKCFTQRAHLRVHRKIQKICKRSYFDVRTLVSDPNCTFTINV
The following text describes a protein:
Function:
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope (By similarity). Plays a role in postmitotic nuclear pore complex assembly potentially by promoting localization of nuclear pore complex proteins to the nuclear rim.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex (By similarity). Localizes to the nuclear envelope at non-core regions after mitosis.
Sequence:
MMGDSHSSFTTTTDEHLYNQFSPGRRKNDFPAASSSSSSPNLRRSPNRTVSSPRVQQKPITIFDQIVDWFQAEISVRKRLAGAACGYLSTIFFIVTVSILKLTIWAPFSSVQDSLAWWIYPNAWASIIFVGIASVAMSLFSIIKFCKVDQLPRLAATDTFALAGVALEFVTRLTFVYTAFCVADFSFSREFAFVAISLAIAISSALVVFRSDYQLNFSHIQVNSVKTLIDFGTSLPYANISEICGIDAAISYTAAVALILVVGPMVSGFSAWWLLLNIPFHVVLFGLCFTQQFYSKISMKIVNQIVMKPISFPFPPPYTVHSPTPEQTRTLPNVIETDDSLLKFFALHDLRTIAWNDEKRRVDVFSLSQPGKHPRNWKAVSLPCVRMLDELCSRMTVSAARLVGYSWDDHDIENEDVPRDALLMPRKMREMAYRGTGQSRQQKSMAPIRSHNTQTVGLLSKISNFLGFGVTEKLVISRFDAHMNAYAAEALYMLVVDSMGEDRFGVVQKDLKDLITLLCKLIAAIDTYERAKASVADKSDVTFLRIVDASLKSSLQRVVTTFGSHLSSLNLPEEHSRTIRMICLTDEL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MQIARDLTPGLANRATVLTIGRFDGVHLGHQQLIRTTVERARALDMLSAVLTWEPHPRAVLQPGQPLQLLSDLDEKIEQIRRLEPDLLVIAPFTPAIRNLTAAEYMARIVAAMPVREIWVGEDFAMGRGREGDIPRLMEIGRELGFAVGALSKYTVAGIPVSSSRIRELVLAGNVAGAGALLGRPFALRGVVTRGDGRGRQIGFPTANVQVSSDVVLPANGVYACRAYLPDSTMVPAVTNIGVRPTFAGTQRVVEAHLLDWQGDLYDQPLRLELLIRLRNERKFNSVDDLVAQITSDVAEARAILGLETSS
The following text describes a protein:
Function:
Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the distal portion of centrioles. Localizes to the inner scaffold in the central region of centrioles.
Sequence:
MSSDEDKCSLHVAHNDSDRSVSTDLQEEYEELLRYAIVNPNVECSASQPSHLRGEVAPDRFPTLAGNNPVRDTELEVGKGSDLNISSHSKSGSPRKPSHPVMDFFSSHVLGDSSSPASLSTRTDAHEINGGEHLVSDENFQKLENILDIWSSGLKTNVLSELSKWRLNFIDWHRMEMKKEKEKHAVVVKQLSNQISDLKELQKAFEISIGRKDEVISNLSRAIGKQKERIELMKSFFRWRIGHVKSRQEIYEGKLADQYFQRTLLKKVWKGWRSVVQRQWKDVVERACQARAEEVCVQISNDYEARLAMLSGALENAKAEIQKMQQEKDHFEDSMKKAFMRGVCALNLEAMTIFQNKNEAGIDFTNNKKEESGPGGPGREPSAHLDTSSSTMPSAVPSQLLPSGPLAAGVASATAFPSAASLTSAGATSASSLHVPISILSAGSAAAPAPEESYAPRVVTAAQQKAGKTITARITGRSDFGSKARINSSLAIMGVSPPMGSVVVEKHHPVTVQTIPQATAAKYPRTIHPESSISASRSLGARPGHAQSLSVQSIKVVD
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MEHKASVSTQDDSGVRIDKSAQQSDRGDCQPKGVLGRKKCILSLDGGGVRGLIECVILERLEFHLQNLEGQNVRIADYFDEIAGTSTGGLIACILVVPDPVTKRPKHTAKDAINFYLQNSPKIFPKKSGLLSSLRSLITRLTGPKYKSAPLETILKEVVGDLKLTETVKPIIIPSYDINYQSSVLFSTTQAISKQIPDCFIRDVCRATTAAPTYFAPYYYTSITDEGERIEFNLVDGGVAANNPAFIAVSELLKTQAVQNEEEMKYEDLLVLSLGTGRTTVSYAAKNAAKWGTLSWIYNNGNVPLLDMLLLASQDIVDYNMSNTFYEQCSHDNYLRIQTEELEESQMQLDNSSQSNLQSLIATARKLLQSKAQMRNRFGQFVPDPRWTIYDAALSQFASWLVRERNARNPPQSL
The following text describes a protein:
Function:
Plays a critical role in cell cycle progression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPKFKQRRRKLKAKAERLFKKKEASHFQSKLITPPPPPPSPERVGISSIDISQSRSWLTSSWNFNFPNIRDAIKLWTNRVWSIYSWCQNCITQSLEVLKDTIFPSRICHRELYSVKQQFCILESKLCKLQEALKTISESSSCPSCGQTCHMSGKLTNVPACVLITPGDSKAVLPPTLPQPASHFPPPPPPPPLPPPPPPLAPVLLRKPSLAKALQAGPLKKDGPMQITVKDLLTVKLKKTQSLDEKRKLIPSPKARNPLVTVSDLQHVTLKPNSKVLSTRVTNVLITPGKSQMDLRKLLRKVDVERSPGGTPLTNKENMETGTGLTPVMTQALRRKFQLAHPRSPTPTLPLSTSSFDEQN
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MKEEENKVTLHGMWANPYVKRVELALKVKGIPYEYVEEYLMNKSELLLTYNPIHKNVPILESPLFPQDQYQRAKVRFWASYIHQVLLMYSTLLLSSQIHIKQTNPYIIFLGYMCMQVYDCMLKVFRGKEALKRFYAKLSVLEDGINNFSLGITSNMNNIGMLDIMIVITLGAYKVQEEVFGFKLLEEENTPLLYSWVTTLIDLPIVKGITPPHDKVVSFLQYLKNKVFKAPPHAS
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSQKQLHTTFVQHVLQKLNQIRIPAIRVDAILDQAYLAMASTKLGSSTASVCSPSANKSSCVSIAPIEPTLSMEYNNNDSIMMKKEEEYQSSWDLCLNIHIVLLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSYFLLMLAQQQTAARRMLDLISPYQLYYYPEAVYRQGEVWRLLTNFTFFGPVSINWIFHMFFLTRYCRMLEENSFRGRTADMAFMMLFGAALLLIFAPLIPFTDQLLFLGSSFVSMLVYIWSRRNPSVRMGLFALLFFRAPYLPWVLLGMGVLLGNDPSADLLGMAAGHIYYFLEDVYAKPRSAGGLGGPRILATPTFLKTLIEGGQDLPNPPADVPAAGGYDWGRPPMADEAGGARQGN
The following text describes a protein:
Function:
Involved in transport of phospholipids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGGKMKICFSKIYSFSCMKCSFKEEHGQIGKRGFSRIVYCNDPDNPEQVQLNYRGNYVSTTKYTAINFIPKSLFEQFRRVANIYFLVVACVSFSPLAPYTASSILAPLLVVIGATMAKEGIEDWRRKRQDIEANNRKVNVYTENHTFQETRWRSLRVGDLIKVYKDQYFPTDLLLLSSSYEDGICYVETSNLDGETNLKVKHALNITSSLQDDGSFQNFKALVKCEDPNEDLYTFIGTLYYDNQQNPLSVQQILLRGSKLRNTDYVYGVVIFTGHDTKVMQNSTDPPSKRSGIEKRMDKIIYILFGTLITIAFIGSIFFGIETKNDISGGKLRRWYLRPDKTSVFYDPKRASLAAFFHFLTALMLYGYLIPISLYVSIEIVKVLQSIFINQDREMYYEETDKPAHARTSNLNEELGQVDTILSDKTGTLTCNSMEFVKCSVAGVAYGRVVTEVERALAKQKRDGAQEVGDTSNDVKESTNPAVNSEKSIKGFNFKDERIMNGQWVHEPHRDMIQKFFRVLAICHTVIPDVNKKTGEISYEAESPDEAAFVIAARELGFQFFERTQNRITLHELDHQSGKMVDRSYQLLHVLEFSSSRKRMSVIVKNAENQLLLLSKGADSVMFEQLSKDGRVFEGITREHLKQYAEAGLRTLVVAYRELDEKEFQSWEQEFLNAQASVTADRDALVDVAAQKIERDLILLGVTAVEDKLQKGVPECIDKLAKAGIKIWVLTGDKMETAINIGYACSLLRPDMRQIIITLDSQDILDLENRGNKETIAKASHDSITKQIREGMSQVSSSRGTTASFGLIIDGKSLSFALDKKLEKSFLELAINCASVICCRSTPKQKALVTRLVKVETHRTTLAIGDGANDVSMLQEADVGVGISGVEGMQAVMSSDYAIAQFRFLERLLLVHGHWCYRRISMMLCYFFYKNIAFGLTLFWFEGFASFSGRPAYNDWYMSLYNVFFTSLPVIALGVFDQDVSARLCLEFPKLYEEGTKNILFSWRRILGWMLNGVLCSMIIFFGITNSLVHQVFRKDGQPVDYGVLGVMMYTCVVWTVNCQMAISINYFTWIQHFFIWGSIAIWYVFLVVYGSLSPIISTTAYKILVEACAPSPFFWLVTLLVVVATLLPYVTYRAFQTQFHPMYHDQIQRKQFESLNSDFSEESSDRGKQKIDL
The following text describes a protein:
Function:
3'-5' exonuclease degrading single-stranded small RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MNDFPDQVSPEQKLVQLTAEHPEYRKNYCFPSYQEGWKVLRIGDVSSLVSSSAMLAIDCEMVLCHDGTEAVVRVCVVDNNLEVKLDTLVNPSKAITDYRTHITGVSKKDLEGVTSSLVDVQKSLKRILSKGKILIGHSLYRDLCALKIDCSQVIDTAYIFKYANLPTTASASLNSLCKSVLGYSVREEGEPHNCLKDAEAAMNLVLAKLKHGFNDPIEVAVSSVITESDSLKLLAHRIPVHLPCQELCKVFSGNPSIDDKIDSRIRGEFYSTCILFNEIDEVEKAFEALDGQMTKDSGGRLQKHVLMKRDNGDVVNFYVRKMVYSSQPNQFEVPKKRPQPTEDAEPKKEHADGDQQKKKRKSKKHVN
The following text describes a protein:
Function:
May function as a transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPSENENKILPFQYVLCTATSPAVKLHEETLTYLNQGQSYEIRMLDNRKIEELPELNGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPAKRTSVFIQVHCISTEFTTRKHGGEKGVPFRIQIDTFKENENGEYTEHLHSASSQIKVFKPKGADRKQKTDREKMEKRTPQEKEKYQPSYETTILTECSPWPEITYVSNTPSPGFNSSHNSXPIGEGNGSPNHQPEPPAPIVDVSAGLTPIQNLLPTTTPQEAQQWLHRNRFAAFSRLFTNFSGADLLKLTRDDIIQICGPADGIRLFNALKGRMVRPRLTVYVCQESQQLREQQQHKHENGEPGNSAFFVYHAIYLEEMTTIELTEKIAQLFSISPHQINQIYKQGPTGIHVLISDEMIQNFQDESCFILDTMKAEINDSYHIILK
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAEENKVTLYGMWATKYFNSQKLALRLKGIPYEYVQEDLRNKSPLLLKLNPVHQKVPVLVHNGKPIVESLVILEYIDETWETGPRLVCESMVSVVKTNGDAQDKTMKQVTETMKLLEEGLKEVVIFSHFGSYEAQEEALGLKYINPEKTPLISSSITALTEIPGGERGAQSS
The following text describes a protein:
Function:
Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. GTPase activator for rab-2. In association with ric-19 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Co-localizes with ric-19 at cytoplasmic vesicle membranes in neurons.
Sequence:
MQMFRHSSADMWRAKKPTLERRSTDGRRSSIVDWINGLSDNNNYKSDHWVEKHDEGCERMTRNGSVCAVEESEPDVPTQHREVLLTKLKIEIKNIMAEHGAKKYLNLNSPYVTSLCIAVDACIMDGLRRRLLTLFNSPSSMSLLQIIAKSNGPAQQVLDQTREIEELRTSAIPVHLIWIREALYLKSLSTIINHFIDSKSVRRYYDNSALLLDPVKGRLVATLMMAPCMVTYRRMSNRIEQEATAEELVEGATRGSTSTVPSRPPLSITRQVSSIAASVERNGSVSRDYVFSLHHSCKSTLLYGKNNVCVAMNGSDFAKGYMSLQKFYDGNLSLKWVPNQLMHASSQPSSGHSNNGEFTNIWKNTINIEMQDIIYIHLHQKDEISPTCLTFVNCEGVQSAPFQLPAGQHSIAFLSSLETGLAPLLRLDPPLWVGTTKEKILPRLRKRSTAVANPAMLDYVFRLVRTSGVEPAPEDIEDPLAPTSHSPPIHDNCVSLPNSPYIVDNVDSIVNFQIGTACQSMRNQIMARAFYGWLTYVRHLRTIRTHLLHLVDTKTLICDDDCDPVDEKFWKQARAEPTEENEKEFLKRVYWRGIEGINTKEVRRMAWPYLLGLFEWNESPESRLEQFTSQYWQDIEEWRVLEAEVRRRDEEAFRAARARKAASPVREESCDVFEDPNEPTCSQHYDRENLITLFRANLHRIDKDVERCDRNLMFFSNKDNLESLRRVMYTYVRRNLEEGYTQGMCDLLAPLLVTFEDEALTLECFSLLMLRQRGKFPQRPGMSKCLLNLRSLIQVVDPQIYALISDIDYAQALSFAFRWFLLDFKRELSYECTYKVWEVIWAAQRLRITDDFAIFFGLATITNYHDVLITNNFDYTDMIKFFNEMAERHDCSRLLSSARTHVKCLQNLVQHLK
The following text describes a protein:
Function:
Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth (By similarity). Autophosphorylates and also phosphorylates Pkn1 (By similarity).
Sequence:
MQRYELIRLIGKGGMGEVYLAHDKACSRRVALKRIREDLSGNALLRQRFLREAKIAADLIHPGIVPVYSICSDGEAVYYTMPYIEGFSLKSLLKSVWQKEVLSKELEEKTSVKSFLPIFDKICATVEYIHSKGVLHRDLKPDNILLGLFGEVVIIDWGAAIFKHAKELKLEQDDEAAVSFDERNICYSSMTIPGKIVGTPDYMAPESLLGVEASEKTDIYALGLILYQMLTLAFPYRRKKGRKLSYRDVVLPPIEMSPYREIPPSLSQIAMKAIAINPADRFSSIQELRQALQPYLQGDPEWTVKATLMAKEKSCWKYYDPILLSRYFPVLASSPAQWYNFMLSEVEISASTRVEYTVTKSAVHEGMGILFLPSKEAERGEFYCGYGLWFSVQNHELTVSLIKNGIEIQKKSQEMISQQSRFAILIEKSDNRIAVFVEQALFILHIDYLPSLGNRLGVIIQDLQGMSNIAISESIGALRVSCLAVPDAFLSEKLYDQAAIFYRKIRDSFPGRKESYEAQFRLGVTLLTQIEEQGGDLTQALSSFDYLHGGAGAPLEYLGKALVYQRNGSFVEEIRCLLFALKRYSQHPEIPRLEDHLCFRLYDSLHKHRSEALVFMLLILWIAPEKISVREEERFLRIIYHKQQATLFCQVDKAPLQFRSSKMELFLSFWTGFSLFLPELFRRAGGLRDYQALADIFYVAGVSGNREAFMQFSTALANVSDEITFPESLHNQKVAELMFFVKGVEALRNKDYQKAKKLLWKTPFTLQLYALDMFHIQAFLDEEIESFIDLLQAIYDPASEEERDHILVYIIQTHLWNRDLERAYKLLNDRFPLDEELAEYSEAFILWGCYLALTGDRVVVKAHFSRCRYKYGKSALIGKCVDGDIFDYLDNLVWWEKKMTLFQSYFLLRCLNESPRRYEKYRQAYLSMENNFFD
The following text describes a protein:
Function:
D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
Sequence:
NEQSGKSQTVIVGPWGAQVST
The following text describes a protein:
Function:
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MVIKHPGPKENIILTTNNQETYQCTLPEVIDEKTRLKNEEQFSSASLELEYLRPLLDDDICTYRPLKVQEYYLGKYSREKYKKDLEKARKDRDEGKSIAHPKKKKVLGVEYPYYEVVYEDGSVCDLTGQPRRSHIQFICYSGGSNEIYELKETSSCEYEIVVLTKHLCQHPSYGPRKSEVHTIDCHLVGNSPMLPSNLRELQFSNAFAKHNKEAKHQQILNTILDVQTLIDEDDDDDDDDVGSGDKTKQPQQLKTDTGAAEATTTSTPKEKHVDMDSVFSIPPSSKHILREFLSGDYCIEGGTGWWKHEFCFGKFIRQYHDEHDFRREIKLGVWNEEKHLQWVNSNSYKKPKPYSERKSLYNLYGDGDYCEEVKKNRMVEVESSLFCDMIRSADDNGLIDYKI
The following text describes a protein:
Function:
Involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes.
Subcellular Localization:
Cell projection. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Chromosome, centromere, kinetochore. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
Sequence:
MEGFGRNEILNWINDLLQLDYKKIEQLGSGAALCQLVDIIHPGKINLKMVNFNAKYDYEYIKNFSYLQESFAKLGVEKYVEVSELVKSRPQANLEFAQWMKKYFDQYYTGEPYNAIERRIALKIPTDKDRSSLKGKTAATGAPPTSKPSPSSTLKPATTAASKPAPVSKPTTTTAKPTPSSVSKPVSKPTPSSISKPVSKPTPSISKPVTKPTPTTTSTSTTTTVSTPPSTPKPTNTPIPSTTGKPTLTQPTFKPTPKSVSPTPPVVAGSTVTTKTVIVSEPPTELLEELEQQKRELEQQRKELEEQKSVIQEMTEKIANFEITIQDIEKDRDFYFERLREAEIFCQDHSDVPLLGEVLKILYNSNGEEEGEEGEGEEQGGEEEEEEEEQGENNIEQEEEEQIEQQQQQQEEEEEHERETLSEPEPDQDNSAIPLEQLEINDEEEEFNQHQEQEEEDEHFEDEEKVNGLNEEEIMNSVLQNASDEDDILESTFDGNEDDSLLQDEY
The following text describes a protein:
Function:
Involved in a nucleolar function.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSDLKSRLKETSNWMSSMFNIIKDPTSESASFSNRVNSVAPPPRRSSSSSSISFSELTNSNENKTTTTTTTTTTSTTATTSQPPQKSPVEQNKEELKKLLQQQLAEMKLKRQGKNSNINDSNNSNNNNNNTDKNKNDNKKEIIKNKKIKEEEESEGEEVEEEEEEESDISDSEDNNSSNNNGSLNGDYDDYGDEISESGSEMDLINNKNLNKEKRKKQEEDLQFSTFDFSSGKAMPTYLMNKGRKTSKKELLEKAEEKERILANSKRNGTNKELADTIRWSTAFDKVQGIKVKDDPALLRKSIKKVEKTKLKSAREWVQRKKEKDEKLKVRIAKREANIKAKIEEKKERRMGIKKKKTNNNNNKSGGGGGNSHASRQRAGFEGKKKFHFNPKKLIN
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MAEQHPRPQEHQGYQTQHQYDQQQQHQGFQYDDQQQPKGFLPQNGPSATHIVAMLTLVPIGGTLLFLSGLTLAGTILGLAVSTPLFVIFSPILVPAALVIGLSVVGILTSGAFGITALSSFSWLARFLSRSRLPQKMGQKVQETTGYLGLKVQETAGYLGQKMQETGGQVGHLLQETGGQVGQKTRETGQNVDKAQDAGRDQEGGRTKEGGRGREGVTVTVEP
The following text describes a protein:
Function:
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MASVSFGGLATGLDSNTLISQLMYLERAPERILESKKSTISSQIDVYTQVTNLLNSFKTLAAGMNTATGFMGKTTSVGDSTVATATSSSIASPGSFNLTVNSLAKNERQVVDQGYASADALNFKTGTFTISGVATPITIAEGQNSLQGIASAINASGANVTASIINDGSANPYRLVITGKDTNNYTLNFSGLTGDPASGSAYTTPTITKSGPTYQAGAAASFSVNGIAITKTSNIVTDVIPGVTLTLLKEGGATTTVTVGNDTSGVTKKINDFVGAYNAAMSQINKQSEYNATTKKGGVLSGDSTLRSVKTQLQNVLTTPVAGITGKYSTLADIGITTDRSNGTLTVDATKLADALGSNFNDVVELFTKNGGVSNLDTEKYGVAEQFRKVIDRFTHAYEGPSSTANGIISSRVRGLNDTIKSIDDQIDAMEVRMERKEEALKKQFTAMETLVSSLTTQGNSLISYLYGS
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Subcellular Localization:
Nucleus.
Sequence:
MSSRKQGSQPRGQQSAEEENFKKPTRSNMQRSKMRGASSGKKTAGPQQKNLEPALPGRWGGRSAENPPSGSVRKTRKNKQKTPGNGDGGSTSEAPQPPRKKRARADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAI
The following text describes a protein:
Function:
Plays a role in oocyte axis determination and microtubule organization during oogenesis. Also required for polarized organization of the bristle. Required, with jvl, for activation of the kinase IKKepsilon in the germ line. Also required for localization of IKKepsilon to the distal tip of elongating bristles by acting as an adapter linking IKKepsilon and cytoplasmic dynein. Involved in dendrite pruning in larval sensory neurons during metamorphosis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Localizes to the minus ends of microtubules in oocytes. Found in a punctate pattern colocalized with IKKepsilon in nurse cells. Displays a punctate pattern in the soma, dendrites and axons of larval C4da neurons but becomes dispersed in pupal neurons which is necessary for dendrite pruning.
Sequence:
MEASAAKITPMASSMSASGSTNSPSSEKMNYALQVALQTIKERCIQLQRRVASMEEENQQLREASSRSEGAPRANEIGVTGDVLSLKAQVSELQRQKEQLEEHIGMVSNENRRLWSRLSQISKDQQLNALPSSTDSRAQQNQNLVRSKTFTQHSPNPHLRQKMLSDGIKDLSLEEIALDDFGASSEELGYPYNLQKVEETTSEPDANVDAKRCLDGLQELRREAMKQQQELRSVMTLLENRIALKPCPECAQKTIKKPEMADKSLETDDSLTSELKNYESQHNGHNGTPPSQRINIIQEKIKADAADAMEKTCPMCGKQYSSQVSFNAFREHVEMHFIDDALELESENSIERQFEFVSHAVGDF
The following text describes a protein:
Function:
Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins; Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MASRRVSPVELRDKCSAGKCWVLVGNKVYDVSAFVNLHPGGERLLQDRAGKDIQADLNGAPHRHSENARRWLEQYYVGELEPQEQKPQNLKEKAQQYSSATDHKDVSTGIQFKTFSPETDLVDWEKPLLWQVGHLREKYDEWVHQPINRPIRLFHSDFVESCSKTAWYIVLSVWVPVVLYLSWYCLTELAQGNTRIFSSFTKDYSVPVPVFFFFPLFLIGVLIWTLMEYAIHRFVFHMNPPASNYYLITLHFMLHGQHHKAPFDSSRLVFPPVPASFVIIPLYILVQLIFPIPVGLSIFVGGLFGYVAYDMTHYYLHYGSPSKGSYLAWLKSYHVRHHFEHQKSGFGITSTLWDRPFNTLIPEDKDKDS
The following text describes a protein:
Function:
Cytoplasmic intermediate filaments provide mechanical strength to cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTYGYTHYTSTSQGRGLASGAYTSGFGGLVSGMSSAGAICTTQIRDAREREKREIGLLNDRLADYIEKVRFLEAQNQCLSHDIDILRRGFSGGGHVSGLYDTEIAQAKRILEQTIAGHAAFDRDIAALGSDIDAIRKKWIDAVNAVKAHREDHDVDLDRLAKVEAEISLFKRKIRIVEEDVIRIRRENDGIYNEIARIKQLTHNEIALKNERSLNVQDLLQRIKLLQTENSTRIEQELVFIRRDTTAENRDYFRHELQAAIRDIRADYEAISIRNRNDIEVWYREQIRKIQTESKPVNQDLYKEELASIRTTVTNVKSRLAEVEGRNFFLEKLIEDLRNNEESKLYEISLAEKDAQIARLREQCTELSIQMERLCDNEISLRAEIERYRVLLNGANVTTYVSNTHPSGVSVGGIVGTTRVISQTTRTNSSSNTSYSGVPASRTGYSVGGNIGGISVGGTIGGVSVGGNVGAHGASGHVSGGAAGSVSSLVSEKRPDRVHDEKGVDASGRSFHSWYLGTISINQITPSYIELKNICKIRRVDVGGFRVEQYINGELLGSAQINVPLILDPQEVVRIHHRHGKYLGQFFMDVDAFDNSTASRTSMYNYTEPNEERAWFVYLN