lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in keratin cytoskeleton disassembly.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Colocalizes with keratin filaments.
Sequence:
MARRSQSSSLGDNPLDPNYLRPHYREEYRMAIDALVEDDIEGYYNFLQNANVVDFLSRSEIENIKSTVQTPQSAGNVPELPYGEIDQDESSDTYWPLHSDLDAPGLDLGWPMQQHSFVGPTEVTMLVNPAEPERPSIKEQARRLIKNAHQVIAVVMDIFTDVDIFSDLLEAAARHVPVYILLDEQNAHYFVNMVASCKVNLEMIHMMRVRTVSGVTYFCRTGKSFKGQVMDRFLLTDCRAVISGNYSFMWSFEKIHRCIAHLFLGELVATFDEEFRILFAQSQPLVVENALVPMPQDSYLGNQFGLKRTQSLRNPRGYLRQPELGGYQYGDRLDSILPFRRDDPFRHTIEPSAGPMQVTKYATQQFRMQQSFLDQGRSMLASRQLEMNAFKRHSYAEGTRETYASSRQYMKQRVMNNLEETESHYQREQHYYQSEGMGHDDRGHYDRFNYGLADQHSDSGYPPELEAPGNINVLSSDDLKSDSEKQYNIGGRYDPQGHKRPAAGHAYACQSSPTQPHPPDQKQLFSTGDQVRQSQDPSVKQGLRSWRINSYLSTYEDGGEEGLHQPMGSDAFEDSHQQPDSRLYGSEGPGIHSNIRERPNIPTKPNLDLRPRFGKPIIQDRNQVKDNTSDLGPTSTDTLKPAISASSLASSTDNEKELAEPREISITKHESFRTRINPMLQRSSRLRSSLIFSSSKLEQHNSSQAKSGGELQEEKEESEPIRYSSIVAEILEKRRSLSREPFDWNKHKKADEKDVKHASTGDLTTIQDTKEEPIKEKEKPDNPKPEENKVTQPTVPSASQQITSSLNMNDPASRLQYFKDQQEKRKTSKLELDLGTKSQEAAIKKPETLDTATKVPDVLLTSEQSTVKAQEPTVSQTDPVPHRPVIETKPKPSEVSVDRPYTTNKTLTESIADAPKKEPVKEPTKSLKPFPSPKFLKPFKSSQSSSRRISCGEEILTDATDAEKSELKKSRSFSTSGMSRTESRESLSSLGNSESKDTKALDFLKKQTQRLKGILGPKGDKKHSGVSNSQEDKSMKTVPEVQEEISDKGKPSESISSSTAVENKPSAKPTTSRYQSSTSNIIFSSNLRDDTKVILEQISANSQKTRQQNEESGKGDGGKDDVANSPFQSRNRFSRAPVNPQERDNLLKRIESMRKEKKVYSRFEVLYRSREECCWERGSVEQANQFLIKSIE
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MGQDKLKVAVLFGGSSEERDVSIASGAQVIQALRSAGHQVLAVDTASGLLGAEEERRLLASKVKEVPPDSDSLAIIRSGKQSLLSAGELAGVDVFFLALHGGTGEDGTLQALLDAGGFAYTGSGHLASAMAMDKDVAKRLFLAAGVETASWLMAPASEEEVREQLGFPLVVKPNSQGSTVGLSIVHSQAELQPAIELAGRYGDEVMLERFVAGREVTVGVLDDQALPVGEILLGGQEVFDYEHKYQAGAVREVFPADLPPAIAAEAQRLALKVHRALKLSGYSRTDFRLDEQGRLWCLEVNTLPGMTATSLLPQAAAAAGIGFAELCERICRLGIERCKGARKARS
The following text describes a protein:
Function:
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
Sequence:
MGEFLKDLPSLDRDNFSRVRKSSSDVTRTTVRVYLSTRDDSSERAKKIGTDKTNSLLRYYYLHSNSKQDHNGENDANSSKESDRKRKLKSKDNSTTGPKKSRM
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATVQEAGSTGFLDPEIKMEDSVGPESEEAKGGGAALPKSGGGESEQTVKQESEEEPSRSWDAQLEEFLRTLQSPSSGGETLQQCDPQEPQTTTMDDGSHLDATHSGKEETAGKDAVELEIQRQHFRVLVYQEAAGPRNFWEQLRNLCRKWLMPERHTKEQILDLVTLEQFLAALPPNMQKWLRGRCPQTCSQAVTLLEEFLLNHRGPKGWEGQITEEFANAPKAKEVQPKMMLRTETEHKHSSNENVLGNDAEMTESEEQKPPFESTEEMEQLMTSMKTGKEDSFLCQGEADKNQERTDKDTGNGKEKVEDLFVSSHVVCKINSEPITWDVEDEVKYDKSGEHFDENTDLVMHEDPDAEQKPYKCWNCGQSFGSSSNLVAHERTHVGEKLYKCSHCGQCERTHTGQKPHKCSHCGNTFGWNPQDKVQPGEKPYTCSECGKSCSQKSDLLKHQRTHTGEKPYQCPVCGKNFRNNSGLKVHQRIHTGEKPYKCLHCGKCFTWSWHFISHKRIHTALCSFCGKSFSQKSELVEHEKTHATEDSFVCFACGKAFAVSSELVAHVRTHKDKPFECSVCGRTFRNSLQRIAHQKVHTGEKQHKCSHCDKTFRWSSHLVLHERIHTREKPYGCSDCGRTFDRRSNLLVHTRVHTGERPYVCADCGKSFISSPVLVRHRKIHVGEEVCTCSQCGKTFQQRSGQAGKVLKCSDCVRSRCLSLALAVPVEEKQFECSVCRKTFRNSSHLITHQSVHMEVQPYQCLDCGRTVVRRPNLIAGQKLHKCSSCEKRLS
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
Sequence:
MMLEVNSLAFSYGNGLVFENVSFSLKKGEVMCILGPNGAGKSTLIKCIAGILKPSTGSVRILGEDTTSLGAKGIARHIGYVPQQNEVVFPFTVLDFVVMGRAPHLSMFASPRAEDMELARESLAVVGLSDLAERPVASLSGGQSQMVLIARALVQQPSLLLLDEPTSHLDFGNQVLVLETVQRLASLGMSIVMNTHMPDHAFLVGSRAAALEGGRLVALGEVETVVTGKMMSSVYGVKVAVREIEDMKRKVCLPLRGK
The following text describes a protein:
Function:
The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring.
Miscellaneous:
MISCELLANEOUS: After binding to gangliosides GM1 in lipid rafts, through the subunit B pentamer, the holotoxin and the gangliosides are internalized. The holotoxin remains bound to GM1 until arrival in the ER. The A subunit has previously been cleaved in the intestinal lumen but the A1 and A2 chains have remained associated. In the ER, the A subunit disulfide bridge is reduced, the A1 chain is unfolded by the PDI and disassembled from the rest of the toxin. Then, the membrane-associated ER oxidase ERO1 oxidizes PDI, which releases the unfolded A1 chain. The next step is the retrotranslocation of A1 into the cytosol. This might be mediated by the protein-conducting pore SEC61. Upon arrival in the cytosol, A1 refolds and avoids proteasome degradation. In one way or another, A1 finally reaches its target and induces toxicity.
Domain:
The four C-terminal residues of the A2 chain occupy the central pore of the holotoxin. Deletion of these residues weakens the interaction between the A subunit and the B pentamer without impairing the pentamer formation.
Sequence:
MVKIIFVFFIFLSSFSYANDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSMSNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNRIKDEL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MEFCPVCGMLLQIDPGTASHRLRLFCSVCPYVCPIQNKIVKKARLVKKEVEPIFSTADEMKSAPKTAVTCQRCNHGEAYFKQMQIRSADEPMTTIYRCCKEECQHEWRED
The following text describes a protein:
Function:
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Specifically expressed in peripheral blood leukocytes.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MGGPRALLAALWALEAAGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR
The following text describes a protein:
Function:
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Sequence:
MSALSASLAAAAAAARASETSRESNNVAVTKARPPQHTLVKPAPAKPPRPVARRPKQPVKITVDTSVANTPAPQGSSATSAAAAAARHFKKQKDEQSSPKLSPHHRPPASHRNSGESAKTPSSDSRPASTTSTIPVTPVSATTPSSTVAAAASAAAKRSSTFNKSVPTPVVSDIMKKEQEENRAAAAAAAAQEKATQIIRDLPSPSNSVRSKRLSQSSLVPVLSDEDIYNHRRYARSSQSFATIPTDEDSPGEMGDFEDNNQVHRERARGIQSAAKHANRLSQTSMDSTHTSQQLQPVVSPHTGLPQEGSVLAAALKAGSNASSTMERISLTNEAKEREKAEKRQRKDAKAKAKLLAQANAVYQQSTNESHHAHHHQYHQGNIFKRVIGKSGKPIDPFQGFSPNFSERPGEHFHNHQREMQGAPDGIRRSMDTSRQSIDAPRQSLDAARQSIDTPRELTTNDTSPIPIQPLKSHDAGAVSDLPTSLDEPGLSGHPHLQQSFSNNNALQTVKSSTDDSMSIASLDSVDDSGPGRPPLLAPIPIRNASIIPVSSESESEDIRRGHRRHLSSSQSQRNSLQFPMSPTFSASPAKQLITPEQLLPKRRRGIARTPSVSSSAPRSSSPVISIPLERSSTLQSTLQGSPMNSPVAKSPVFFEGNNGSTNGGLGSSMSNSPPDSELALTPSESTAHSYFAREYREPKSSSTRGVEGASRLAKKLPHRHLAAGGKSIVKSIWNKATPDAPPPPPVSTGGMKTSLRKQPKKKFNEDKPWKHHNDADTLTDADRKRYDGVWATNRGAHVPYYMEPEEYDILIDEEEFYDEGFLSDSDFTDSDSDDDSVSSAEYIMSGENIGNDDVVVSDQNDAVHGYIVSRLWRRSRLPDERLSDIWELVDRCNDGTLDREGFLVGMWLVDQCLYGRKLPNKVDPRVWGSVGRLNVNIKIRQKEPKRNSAKRKARRKVRRDRKELVRERERNEKERRKDEKKEKKDEKKDKKDDRRRDKKRVGEA
The following text describes a protein:
Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPNTMETIYMILIASELSIGIWGNGFIVLVNCTGCFKRSIISLIDIILVPLAISRICLLCVISLDGYVMLLSPDTYDHGELMNILDVLWTFSNHSSVWFTSCLSIFYLLKIANIAHPFFLWLKLKINRVILGILLASFLLSLIISVALNEDSWYNFKVNHEGNITLKFKVSKVSNAFKQIILNLGAIVPFILCLISFLSLLFSLFRHTKQMKFHVTGSRDTSTEAHMRAIKTVLIFLLLFIVYYAVFLVMTSSYLIPQRKLRIMFGGIIAVIFPSSHSFILIMGNSKLREAFLKVLRTVKGFHQKRKSFVL
The following text describes a protein:
Function:
Involved in pre-25S rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDKKTSAESPANQASEIPAALPFLAVEPQKVDSSLDDLFKNAAPVQRPPKRDITVLEQPEPKNNDEETAASAVDEDVAMDGEQNGENDEKESKASVELSQNQQRKKAKKQKKQKDESLEANYLEKLAEEEEEEQKTQEKKDEKEDKKEAEKEEEIPEEEKPLVEIENRVNKELEKSERTVFVNNLPAKIVTDKKLTKSLKKHFSQYGKVQSVRFRSIAFSEVIPRKAAFIEKKFHDERDSVNAYVVFETSKAAREAVKLNGTMFLNRHLRVDHISHPAPQVNKRCVFVGNLAFEAEEEPLWCYFEPCGPVEYVRIIRDPKTNLGKGFAYVQFQSAESVDKALLLNGKKMPEGRTLRVSRCKVAKQNKFKGKGKRKGDQHDRTLEGRSRNLIGKSGQAIIKQGIAMALEGYRAKAGDNPIMKKHRKKKPVSKTKKGKH
The following text describes a protein:
Function:
Phosphodiesterase which displays a preference for cAMP over cGMP. Involved in the degradation of extracellular cAMP. Maintains the responsiveness of cells to the chemoattractant cAMP during the aggregation phase of development.
Subcellular Localization:
Secreted, extracellular space. Cell surface.
Sequence:
MALNKKLISLLLLIFIILNIVNSHQQEDCDDDDEDIGISAERSERRSVKNSNDGSNFYNLNDYYTPENWNYYSGSFATKDCRDASYITIPLGTTGGLDEGNLSSFLLTKKGSNLFIALDAGTVWQGVRRLTTFKYFNTLFNITYPSWAVLPEQRTSWFLKNHVMSYFIGHSHLDHVGGLILVSPEDYLAKNWIDVQPPINNGIMGLIRKLGFKPTDFTSSSILQKKTIMGLPSTINSISTNLFNNQVWPNLPSFGRYQYFSLASGIEYPFTELVPYNATTMSLVANEFPFSVKVKPFELCHDNLISTSFLFTDSISGEQIAFFSDTGVPSSVACDWEGKIYAVWKQIKIDKLKAIYIETSFPNNTPDSAMFGHLRPRDVMKLMDQLLVQSIQTSPPMTNLKHVKLIIEHIKPQVAEDPNGWTTQRVIYQQLKEANNNGVRIIIPNQGDPICI
The following text describes a protein:
Function:
Serine protease that may be involved in the light-dependent degradation of antenna and photosystem II in chloroplasts. May function during high light acclimation in plastids.
Subcellular Localization:
Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane. Note=Mostly exposed to the stroma but behaves as an intrinsic membrane protein.
Sequence:
MAKLLLLHAPHVIPRFSSSSSRSLVSAAALYRRPLLVNPQFSHIGPRLHSPYNRRFSARAFDDSPASSAEMEKEKQEQLLDGVSGKKDEDYPTGEMEYENRNAWEIFVVKFRMLFAYPWQRVRKGSVLTMTLRGQISDQLKSRFNSGLSLPQLSENFVKAAYDPRIAGVYLHIDPLSCGWGKVEEIRRHILNFKKSGKFIVGYISICGLKEYYLGCACNELFAPPSAYSFLYGLTVQASFLGGVFEKVGIEPQVQRIGKYKSAGDQLSRKSISEENYEMLSVLLDNIYSNWLDGVSDATGKKREDVENFINQGVYEIEKLKEAGLIKDIRYDDEVITMLKERLGVEKDKKLPTVDYKKYSGVKKWTLGLTGGRDQIAIIRAGGSISRVKGPLSTPGSAIIAEQLIEKIRSVRESKKYKAAIIRIDSPGGDALASDLMWREIKLLAETKPVIASMSDVAASGGYYMAMAANAIVAENLTLTGSIGVVTARFTLAKLYEKIGFNKETISRGKYAELLGAEERPLKPEEAELFEKSAQHAYQLFRDKAALSRSMPVDKMEEVAQGRVWTGKDAHSRGLIDAVGGLSRAIAIAKQKANIPLNKKVTLVELSRPSTSLPDILSGIGSSVIGVDRTLKGLLDELTITEGVQARMDGIMFQQLGRDSLATPIIDMLKDYLSSLR
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MAPRLVSVAELHGHIDRVWQISWSPVVLALISASGDKSIRVWKPASESDKSNWTCSTVVDDAHSRTVRSVAYNPDGRVFASGSFDGTVGIWERDNSKEMECVASLEGHENEVKCVAWSASGVLLATCSRDKSVWIWEVVGDDEYECSCVLQEHTQDIKAVRWHPFEEILASASYDDTVKIWKEEDADWYCSDTLTGHTSTVWNIDFNQSGDMIASVSDDKSLRVWKQDPMTKKYQPYITSLNHHDRTIYSVSWSKHHGLIATASGDNTICVSSIQPKNNINQDMDPKHPDLCDATIVKLTTLVNAHGLNDINSVVWCPIEGFQNYLASAGDDGIVRIWEYMDA
The following text describes a protein:
Function:
Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVQITVDDMVLKVVILLQMGTGLLANTYLLFMHSFVLLTGHRPKPTELILSNLALANSLVLLSKGAQQVMEDLGLVHVLEGFGCQVFFYFHRVSRELLLCSTSLLSCFQAVTVSPRHGVWTGLRRWVYRHVGCSCFFCWSFNLVISTISPIEIKVFGDIISNSSMGDGIACQYVVAVSGLCAIPLAILGALLMTLMVAASTHMVCLLHRHHQRVQHVRSCNLTYRTSPEMRATHSILLLVAGFILFYFLNSIYIFYSIKSFSSYLWLQHSLKFFATCFPSLSPLVLIFQNSRTPSPCF
The following text describes a protein:
Function:
Multidrug and toxin efflux transporter involved in flavonoid metabolism. Required for proper reproductive development.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MDPTAPLLTHGGEVEEDYAPARSWTDVKRVLSTESAKLWMIAAPVGFNIICQYGVSSVTNIFVGHIGEVELSAVSISLSVIGTFSFGFLLGMGSALETLCGQAYGAGQVNMLGVYMQRSWIILFVSCFFLLPIYIFATPVLRLLGQAEEIAVPAGQFTLLTIPQLFSLAFNFPTSKFLQAQSKVVAIAWIGFVALSLHVIMLWLFIIEFGWGTNGAALAFNITNWGTAIAQIVYVIGWCNEGWTGLSWLAFKEIWAFVRLSIASAVMLCLEIWYMMSIIVLTGRLDNAVIAVDSLSICMNINGLEAMLFIGINAAISVRVSNELGLGRPRAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTSSKVLQRAVSKLAYLLGITMVLNSVQPVVSGVAVGGGWQGLVAYINLGCYYIFGLPFGYLLGYIANFGVMGLWSGMIAGTALQTLLLLIVLYKTNWNKEVEETMERMKKWGGSETTSKDILA
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTRAMVRPELDLNSLKCITKVLTILGLLSCSFPKKKLVYCIIFGAIATLTCIEGLRDCPRKYSTPLAKITTILQRYCSVLLVFLTYFFNILFRKKLLNAVKILSKIDETLNSKPLKPVKIRTKVYLVYCSSALVLAAMTTFHLIYEAHGFSYKCGIQYHICNTVISATVCFMMLLMLEIWRRFTILNNYLTIVLGETWTSLSVYHLVEISEIHFDLCQAADDLNRYFEVQVLTIFGVSFYFFISTFFYFFTTGNIIATYDKQFYIHNALIVRALFLFFQLWATVYTSSQVTRESEKTAEIVHTTKRNTLNSSLRVWVELFSHQTIFKRVNFTVLGLFPIEWNVIFGIVCATTNYLIILIQFNDHILKLS
The following text describes a protein:
Function:
May act as a formate transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVDPKEQILYGVDTTFEGIAKKATPKFRTTPGRLLFAGFMAGAFIAFGFLLAVVAASGYSPKLFPDKGNISAFKLLLGAVFPVGLIGVVIGGADLWTGNVQFLSSAKVKGYADFKCVLYNWFGSYGGNFIGSIFLALLATTLTGLFGHVGDPNTFGKVTVSIATGKVSKDMLALFFLGIGCNWLVNLAIWQSARVQDGAGKILAIWFPIFAFVAIGFEHAIANMWAIPTGILLSNYTITWTKFFHNLIPVTFGNAVGGFLFVAFYYWYLSHPELTAERLIKEIVDFLVVFIAFWIVATLVPAGIAMALDSALGSGAMYAVPLALSIYYIAGTFFLAKIAKPA
The following text describes a protein:
Function:
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSIKIENLTHVYMEGTPFEKKAIDNINITIENGEFVALIGHTGSGKSTLIQHINGLLKPKSGNIIIDNVNIADKGVKLSSIRKKVGLVFQYPEYQLFEETIEKDIAFGPINLGLNQEEILNRVKRAMNIVGLDYEVYKDKSPFELSGGQKRRVAIAGVVAMEPKILILDEPTAGLDPKARDDIYSKIQALRKEYNMTIILVSHSMEDVAKFADKILVMHKGRCVLQGEPCEVFKEIDALESIGLAAPEVTYLVQKLRKKGFNLPDNIYTIEKAKKELLKSLKSEGIIK
The following text describes a protein:
Function:
Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities.
Miscellaneous:
MISCELLANEOUS: Present with 930 (+/-45) molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSSNPENSGVNANNNTGTGNADAITGAQQNMVLQPRQLQEMAAKFRTLLTEARNVGETTPRGKELMFQAAKIKQVYDALTLNRRRQQAAQAYNNTSNSNSSNPASIPTENVPNSSQQQQQQQQQTRNNSNKFSNMIKQVLTPEENQEYEKLWQNFQVRHTSIKEKETYLKQNIDRLEQEINKQTDEGPKQQLQEKKIELLNDWKVLKIEYTKLFNNYQNSKKTFYVECARHNPALHKFLQESTQQQRVQQQRVQQQQQQQQQQQQQQQQQQQQQQQRQGQNQRKISSSNSTEIPSVTGPDALKSQQQQQNTITATNNPRGNVNTSQTEQSKAKVTNVNATASMLNNISSSKSAIFKQTEPAIPISENISTKTPAPVAYRSNRPTITGGSAMNASALNTPATTKLPPYEMDTQRVMSKRKLRELVKTVGIDEGDGETVIDGDVEELLLDLADDFVTNVTAFSCRLAKHRKSDNLEARDIQLHLERNWNIRIPGYSADEIRSTRKWNPSQNYNQKLQSITSDKVAAAKNNGNNVASLNTKK
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNIRPEIKTAFIVIILGIAIWILLTFPFRYGLDIRGGIRVTLQCQKTEGVEITDDAVRRTIEVIRNRIDQLGVTEPSIYKEGSDKIVVELPGIKDPERALEIIGQTALLEFKDETGKTILTGSALKNAKVEFDQVGQPMVRVEMNPEGAKIFADFTSKNVGKQVFIVLDGKVISNPVIKEPITEGTGVITGRFTIDEAQKLAILLRAGALPVPVKVIENRTIDPTLGKDTMESAYRAGVIGAILVVLFMILVFRFLGLVADIALLIYVVLDLAALKLLNATLTLPGVAGIILSIGMAVDANCLIFARMKEEYAQRKTPMASLDAGFRNALRAIIDSNVTTILAALILFYFGTGPIRGFAVTLSLGVALSMFTQITITRTLLENLLSLPVFKKATKLLGL
The following text describes a protein:
Function:
Mitochondrial protein that may have a role in mitochondrial translation (By similarity). Essential for larval development.
Subcellular Localization:
Mitochondrion.
Sequence:
MYLSRQLRLLPRANIACSLSSSGAHYTTAAPAEDAPIEIPNRIERSPTDLLQALASTVARDYTAPHYKYHDDPFLIPMSNAAKRTYAMSKESGRKAAKWIKEEHRELFMHQEAQPAIEKFAPSMVYTEDSVVDETSLAQLISQGELKDAVLVYNLLEQKGNPISPELKQSLLELVCFHNNQEPIPEEYIEERWFLQNNKRRERSGKTWKDGDLAEKLYSEIEPKTPQSYASLIRGMAKYLQCERAYALLQEAGEKQVQLDTNTFNSVIEIVSFLKDTAEQRWQLCKDLLNEMSQQKLRPNLGTLNAVLQCISTFGNFKVARAAALQALPEFKQLGVNPSLGSYYYLLIIFCRERGPVSHVIVDILNDISGKEFQIQHPKDTYFFATAMDVCRNHLHDKSLAKKVDELLHTGKNYDLVGDSFKESIYYRNYLALLCQTESTEDFMLSYDLLVPNIYIPEPGIMEEILRAIEINGAVEYVPRLWSDMVVFDHTHRESLLLYVLRILVDNKPNPDSPAQAQLPEQGAKVALDMFERVEEAIKRLRKVSFTGQMLGDILTLLVRGGSYEKATEVFAHIDKNQHRIPGTPSLNALIEFVDASVQEKSPSQALFALQYAVENNFDSRELAKRIHEGFTLNETHLSKLKSLVGESFLDK
The following text describes a protein:
Function:
Has no hyaluronidase activity.
Subcellular Localization:
Secreted.
Sequence:
DRTIWPKKGFSIYWNIPTHFCHNFGVYFKELKQFNIKYNSMNNFRGETISLFYDPGNFPSMVLLKNGTYEIRNEGVPQKGNLTIHLEQFTKELDEIYPKKIAGGIGVIHFHNWRPIFRRNVDNLKINKDISIDLVRKEHPKWDKSMIEKEASNRFETSAKIFMEKTLKLAKEIRKKTEWGYHGYPHCLSGSTDKPSFDCDALSMSENDKMSWLFNNQNVLLPSIYLKNVLKPDEKIHLVQERLKEAIRISKNFKHLPKVLPYWWYTYQDKESIFLTEADVKNTFKEILTNGADGIIIWGVSYELTDRKRCEKLKEYLMKILGPIAFKVTKAVKENTPLNF
The following text describes a protein:
Function:
Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily.
Sequence:
MTTEYLDEERDLPLPRQKKGIDHTQTEPIRGFFGVKDMFAFENVGFTRSSEGKRYLVCGECEQGPVGFVDPVTEMNYVSPERLDVLPDVAAAAVEAGK
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Sequence:
MSLPEEIYTSAMLAIACNDDKKAQEILVSLLQTYPDLVDYAKSISPATGKLVLRQAKRSMDAYDSIKKGGSVLSLAEKIVYLSSRTNYGYALPWEYATPVSALKKSDDLYVDATDGGLRQSQHRDVSWLRIPHVFASSDAVFTWSGFETLYQDGLENCSFVASLLSIGVMEKRCNYSLLKEALLDKSSNHHLGTPPSSGRYDIKLFINGCDRRITIDDRFPIREPSLPNMYLRSYTNPTLVWPALLEKAFMKVLDGYDYAGSHAGGDTFVLCKWFPEFVSLTSYHDTNGLWRYIYDSWLQGDVLLCLGTGSFSREEADYKGLLGEHDYAVLELREIQDGCNTAHILRIRDPLLFGPFSNPKNPLVEESNRLAKLVDGKNVDMASRGEIWMDFNQATREYQSLYLNWRPERFFCRLEQHFFWKTSDIMDFQMCGSFVQNPQYTITNNGTKTATGKLVLLRHTQGRETDAKSFCCIHLFEGATRVVLQETSHAVYKGKLMNLHYYTVSLTLKPGESTTAVMACSGMTDSEPMYRFSLFLYANNPLTMSKPTAPLAYSQIFKGKWSEDQAGGNWAKPMYIHNPQFLLTVNEHCDQLYIYLTSSSRQPIAAQLFWGSKSLKEYKESAIETSSGKYKTGSTHLKTRNIDAGSNLILIISTFDSAPQTDYNIRVFSSGNFSLTQLARHTAGKFTKSHKSKFYNSCSEQVEFSVQQSTQHLSLAARMIKTRPFIRLTIREAQSNTVVATTNTFSDSIYGVHLDGVRVSRGLVYLAVIEKMEHSNNEPYVMEFAADTLVTLGH
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MVSQHGILLAVAIISDHFGPLVSKVCRCLLRHGALPLQEIVRRLELSPGQVKNSLLVLIQHNCVQAFNAPRGNGDKTVTHYLAIFDNIVHRQRFSKFLSIIRADIPESEALLEGLLQNGRLTFGQLVERTISKVPEGSITPAREEIRMNFNKLVFAHYVERCPKPEPFFDPLVDEQSTSSRKRAPKTVEIALSIDKKVVNTAALSDAERFSEIPYIMEDASNANDSPRSSISGAKRKHNALEGDAELDSTIAENEVLWRANFEKFTFCLKKKFCADRKKPKLKVGTHPIWEAFFEASLMERDNNSVTSPINGIMERLGQKEGGTSMTLDHITRVLEELNCSPSSEDPDSFILDLSRIVEASRNEEIESLVRKKYGQEAFTIFRLLVRERGPVETDKIIDTTILDKQIVHGTLYKLWKDDYIDTERILSGTGTGNTQYFVWRVKNTFREQFIDNLCHAALNLRQMVNYIAELLLEGSKDDTKLRNRKNILILALTRHDDSLMLFQDF
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Membrane, coated pit.
Sequence:
MPSKPMNNSMRGLQLFIADLKSAQLQQTQQKRIQSELVNIKTNFGTSGLNGYQRKKYIAKLVYIYITTNTAKVGEVLFGLEQCLVLLKSSVYSEKAIGYQALELLMHHKEAQESVLFPVIEQVKLDLTSADTDTVALALNFLGIAGGCSRTVGNQLFYDVFKILKSPLAPSLLRSKAALAFLMLVRKSPEVLTDQDDATLAEWVRCIFALLDDEKNYGLILAGVPLIEYFARHVAYDQCIKLVPKLIQILYSCVVVAKDNPNEFPEEYRFAKMPNPWLVSNISKLLNVLITPSDSHGRFTSLNIDQQSLGRLRLCVTKVIEFNGIQGTLSNATQHAILFTLINLACKLDPTADALNNSVAVLTSLLGSKDTNIRYLTLDALTKMSFSSGGRVKDTLRKDYLPRLLQILQEERDASIVCKVLDLLYALASEENVEYIVEQLLHFLASSTKRPLSIRNDLCVKVAALIENSSKSPEWVALSLLKLLSLTPVESNSTKGDMICQRVCYLVVNEERLRKVTCMNLVNYLLAPAPSTCILKASAFIFGEYANLLLENISIGDLFNVFAEKYFQSDNTTRAMILTTLIKLYRFNPAIGSAAIKFYQLELTSLDLELQTRAYQYLKIIQLDKLKKHDMKLLDTIFSEMPPFPRKKALFAPDNATGEFSEDSELPSFTDNIPSSKSNSRAPTPAPTPPPSRNIKTTYTSVTLSDGWESGFKRMLLHQQGVFYKNSLLKVLYRIIQNPSQPSISIVSLTTVNNAELPITGFYPEVIPFRTSGNPSYITNVTEMSNFTIEPGQRTNFSFELQTRYSFPVIEAPIVTFNFRYGGHNRDIGLKLGYGITSTISSKDNVSTMAQFIQRWKTISDALGHHGEAQDVLDPESSTQLEVNLQRMGFAIVEQESVPHTVFATGIVHTKSSGNFGCLLKLMITDSAVKLTCKTTSDGSLAQELVECVVQAFHSTT
The following text describes a protein:
Function:
Involved in autophagic vesicle formation.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MDYEVSRKVWDSQIPVQFTLQAGGPLGDPLPYYTMLPRFTYLALTLPKVLSSFNRRENGETILAEKVHLEVNGAPVKMYIPVGVIYDQLNQKNLESEGILEIHVRTSQPAPLDFQMVSVDSMRAMFCQTVKEADYLKTKAEVTSSLMKEDMPQLWQSVVNNNFDEYWGMIQKLMDPKDGKDFLHVPLRVYVKNQPFKQALITVKHPDGSLRTIGDAVSEILQLSTSSEASTPTSESSATSSSEASSPDDRRLISHGIDVPRHTPLIFAAKNLSYPDNFVHIVIAEAR
The following text describes a protein:
Function:
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAHSPSVVNSNDEPGYDLDLFCKTNHYAEDLQKVFVPHGLIMDRTERLARDVMKEMGGHHLVALCVLKGGYKFFADLNRNSDKSIPMTVDFIRLKSYCNDQSTGEIKVIGGDDLSTLTEKNVLIVEDITDTGKTMQTLLSLVKKHKPKMVKAASLLVKRTPRSVRYRPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVITETRKAKYKA
The following text describes a protein:
Function:
Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. May function in assembly or stabilization of the NDH complex. Required for the accumulation of NDH subcomplex A, which is a core part of NDH. May be involved in post-translational steps during the biogenesis of subcomplex A.
Subcellular Localization:
Plastid, chloroplast stroma. Note=Previously localized in chloroplast thylakoid membrane fraction.
Sequence:
MATKAVLLPWLIPSPRHVSLFPVVQLPALETAGWCVRKRRAEDVAVSVAFNPSGNFDISAFENDQDSDKVEPPMPPTTGRYEVVIDNDSIGRLDLSPFQRAIGITSPDDFGVAEPKRYLDRTIGFTINYKREDPGDPRELSEYPDVRLWFVRLDAMYPWLPLLLDWRAGELARYAAMLVPHQMSLRMGVVFNPEALELFVMNKVFVVYPWLKRHGVPKPRLKTSDMARMLGFGIGDELFDLIDHNE