lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for replication of kinetoplast maxicircles, but not minicircles.
Subcellular Localization:
Mitochondrion. Note=Localizes throughout the tubular structure of the single mitochondrion.
Sequence:
MSSKTVVWSSLGRFMRTSHHRLLDEKLFPASHNRHVQSRLLSTPLSLIAVPSWMSKCRTSAVRLSRHPPQVSGQEPCAVTASSSVGTWHGSSPAGLRRCQHVRSLNGWTTPGDVPIRHGSRSIATIATGCGGVGAGGINSSVDVAEVSGVSTSGVAAAPTVALPPGPPVEKPPLICVVRRATRGGAAADSVGTGTPGKCDKPPDSSNTLVGTIARVLSSSGECGRHSNANQEGYSLGSRPARKILVKLEADTVAAPLADTKEKQIYVQQQPVVVAQSPLARSSSTVTWEEGDTLVYNIFTQRVVKSSSASIRALSVLGVGVRSSEKELSVVDPHALVEFRDKLREKEVSWPSAWRSSLFNQLQHVLLKDQPMEEMISRVHELLQLHYQRVKRSCVANVTKGEPDTKTEEANPAGDEVAINGEMTYHERLLGYPDLNEEQRRVVDFVLRGYNTYIGGGAGTGKSLLLRVIRQELVSRGLTVATTATTGIAARRLNGATLHHCFGVNVYGEFTRRAELKEFDVIIIDEVSMLSKELFESLEFQLRRANGVDLPFGGVQVILSGDFLQLGAICSVSLVHSSVFRRNFAMLKLQRVVRQEGSSIFAQQLQELRRGTVPHDLQDTVQFLSPPETAKWLEGEGKGAVKLLPTNKEVDEVNQAELDKLPSDLVVYPAQMQAPSLVGRWTATYILEAVVKDTKMIDTHKLTRALEQYVLDFLQKTPYASDYTLPVVGQRYIVLYKLFVDAFAFRVRIPQDMSEKDMRDLALHLRGLETWLPACGLGVFLREILDSPDGLHTDADDYTLTRYAELHPMASPLRLKKGAKVMLRTNLAPGLVNGSLGVVVGFKELSAKHLPRFVNTPGRIAAVENYAEYLRYEHGFTTAFAPEVDFGGGRVIVVPPVLFSVGGLSNTNHYHVGIVSLPLSLAYAFTVHKVQGLTLAGRVHLELSRMWPCDHLLYVAMSRVRNPEQLTVSSFHNSLVRCASECLLFDDSLPPVEQVRVLPHFFQASWQRTPSRRKAALQRKREQAKQSKQKKAAKLKEAMIKQAKEATP
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGMGGGNGRGRGLESGSAWELNMSRTDSLPDPSLYTVKAVIILDQDGHRLLAKYYENDFPSLAEQQDFEKQIFRRSHKAESEVLLVDGVTALCQKLSDITCYIIGGLHENELLLLAALTCICESLCHMLRKHVDRSSLLENMDTAFLVLDEIIDQGVILESDYQQVVQRLSFKSISEPAFGFVLFDYLTGSGEQGTSQKDQA
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MAATPRGTSPVPPDARPRLTVLSGPSGVGKSTVVAHMRKEHPEVWLSVSATTRRPRPGEQHGVHYFFVSDEEMDKLIANGELLEWAEFAGNRYGTPRTAVLERLEAGEPVLLEIDLQGARQVRESMPEARLVFLAPPSWDELVRRLTGRGTEPPEVIERRLAAAKVELAAEPEFDQTLVNTSVEDVARELLALTNVV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
Sequence:
MDIPDCAVCLQTCVHPVELPCSHVFCFLCMKGASTQYRRCALCRQEIPVDFFSSPKLLHHHDEDDEGVEEEEEEVEESYTWFYEGRNGWWQYDERTDAELEESYRANKRTFELLIAGYVYVIDLDSMLQYRRSDPSRRRRIKRDLVGAAKKGIAGLKIKVKREEDSADRRVVGAEEDKENGGAVGGAIASDEDSGMVKQKDDCTQDGTVPSEKEGVESDASTQVTRAVSPNANHSNSAGNETVYEVVRSAPPQTSRTGEESSPSNFSYTNPSPADNPPPTYAKPIRQRRRPANESSSSGASSQVVNDTQGDSPVSQRLTVSHQRTHSAPEPRPSSRPRGPAPQAPPRNLVSQQVSSSAAQRTESEDTPSHVERITETLRSELVINVSPNADTGSGARRRQVRRHVHEV
The following text describes a protein:
Function:
Together with TRK2, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVLNYIQRWFKWVIPTFGFLAIHYIYIISLTIIASILLFTGGTTTKIKYIDALFLASSATTQTGLNSVDLNSLSIWQQFILYGFTAITVPIWMHGSISFIRLYWFRRKFKDVVRQNRTRKFQRKLRKSLMKKSEDDEEQGVRGRKIRVMLPYLHSLRSPTSLKNFSRFDTHDSTNNPYFPDNPPSPKADISKDEYFGKYLPKKSDTLDMDLESHNMTFHDYEPSIENKNYDFGSSHSASMQMYEMDDLHPRLRRQSSFISSVNPLEADDTRETLSEGALVQESLPMAYSYSDTNLVVSRDSFTLTGDDNLFPEGGLRPANTIDGIVRSSLSSSSLSKDTEPSTVDMHIAFTGLNKPTIERERNLKLRKKSRFYKKSLRSRFSRGLHRPIRWTKSFTSNRRNLTLERVLSSAFAKKREPSISSRHTTMSLPYLSYNPTVDRNSAFVALSKEQRDELGGIEYRALKCVCSMVTLYFIIFNIAAFVTFIVFAYTAVGSREVIDSYDLRRGWWALFSSASSFNDLGFSLIPSSFVPMNRNIFLLLISSLFIIAGNTGFPCFFRTFIWTTYKLYPFSFEKKEAMAFLLDHPRRCFTLLFPSGATWVLFFVLLLLNVIDLVLFMVLDTGSKAVASLPKGIRVVNAIFQSVCTRTAGFTSVSISELHPAVLVSYMVMMYISVYPVAINMRNTNVYEERSLGVYRTEDDEGKSFLKDHLTEQLSYDLWYIFLGLFIICICEGGKISNPLDTDFSIFTVLFEVVSAYGTVGLSTGLSSSNCSLSARFTTISKLVIIALELRGRHRGLPRAVDRAILLPSEKNNLKEEEDYQRRHGFSIDNARGSIAVSRD
The following text describes a protein:
Function:
Subunit of the 11S REG (also called PA28) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates preferentially the trypsin-like catalytic subunit of the proteasome. May also be involved in cell cycle regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSKNNSTVIKMDEQVLKYKEDLYEKTVHHLKVTIPKKIAEYQELAKSYGQNSENEQDGQTSKKRKLDSEDYVLMPIEDLIKTNRVIMETHQKFKKAYIELIETFSVIRGWISLNIPRIEDGNNFGVDVQEDIITQITKLEEVYTSLLDGSESYFASRASLVKKILKHKDIEAYRYSLAQVDEKEFTRFSFSYFDLANNYATTYSLIVKNFAKLETPRPTNASNIY
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MKISVSKNDLENALRYLQAFLDKKDASSIASHIHLEVIKEKLFLKASDSDIGLKSYIFTQSSDKEGVGTINGKKFLDIISCLKDSNIILETKDDSLAIKQNKSSFKLPMFDADEFPEFPVIDPKVSIEVNAPFLVDAFKKIAPVIEQTSHKRELAGILMQFDQKHQTLSVVGTDTKRLSYTQLEKISIHSTEEDISCILPKRALLEILKLFYENFSFKSDGMLAVIENEMHTFFTKLIDGNYPDYQKILPKEYISSFTLGKEEFKESIKLCSSLSSTIKLTLEKNNALFESLDSEHSETAKTSVEIEKGLDIEKAFHLGVNAKFFLEALNALGTTQFVLRCNEPSSPFLIQESLDEKQSHLNAKISTLMMPITL
The following text describes a protein:
Function:
Plays a role in the sugar gustatory response.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKVLSNDLFHHRVKWILLLGQTFGLLPVNGVTSEKCNLTFSWYSKKVFYSKIIISGSIFMTTTSFYRILNSGYNLTTFGSFIFNANSAIEGIIFFNLAKSWPQLIEKWSRVEMALDNWKNDKSLKRKFYLTICTIMSAAAVEHILSIVNTCSQIPSEVEDKYTTYFLNTYPHLFNFFEFSVPLAIFAVVMNLCNVFVWNFLDAFLIIISIALTEKFRQVTAKVIVAHNEKIHLKHHWVKLREDYNQISILCKTVNKKISTLIIVSFGTNMFFIMSQLYWSLSIVKTTPVESIYFSFSFGLLVLRTIAVTLFASNINDESKKSMNYLLSLSSDIYNSEVERFAFQIHSQPVALTGNDYFTITRGLLFSMAGSIVTYELFLIQSNEAVSY
The following text describes a protein:
Function:
Major facilitator superfamily transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MWTTTSGLSGRSLRLSITFAAVVGFSLFGYNQGMMAGLLNGDEFVNSFPILKMPDNPTAGEKHYIDVIRGAVTSCYELGCFFGALFSMFCGNRLGRTRLIFMGASILIVGALLTTVCYTGKWEVGQFVIGRVVSGIGNGMNTATIPVWQSECSGAHNRGFLVCFEGAMIAGGTFIAYWVVFGISHAADSVQWRFPVALQIFFALVVATGALMLPDSPSWFVSRGLDNEACEVLGKIKGTSPDSDQVLHDFNLIKTDMESTKSEQSNWKTVFTFGKTQEFQRLLIGCSGQFFQQFTGCNAAIYYSTLLFQENLHMEKYLSLIMGGVFASVYALATIPSFFMIERVGRRKLYLIGFLGQGLSFVITFACLIKETEENSKGAAVGIFLFITFFAFTLLPLPWIYPPEINPLRTRTVGASASTCTNWMCNFAVVMFTPLFAGQSPWGVYLFFALFNFVGLIFGYFFYVETAGRELEEVDIIYAKAHVEGKMPFRVAHDLPKLSFEEIVQQSRELGLDTNDHVMLEKKELGLSSDSAQETEEVYEKQ
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRVKKRSKNRKAVKFYSTCFGFREPYKVLIDGTFVHHLLTQRLLPADDALRDLLSASRTPALFTSKCIVAELRRLGKSHAESFDSAQLLATTKCEHDKVVSAVNCVLSLIGDKNPEHFFVATQDADLREKLREIPGVPVIYGLKNSLFIEQPSVQQRKFAQLDEEKRLNMDISEYKKLMKAASEGKTTASENGSDGEQHERPISSLVKNALGVADKSKFKRNRAKGPNPLSCKKKKPKPQPSAIQNQGATADGEAKRKRVRKRKRSQKDNKQAEMAS
The following text describes a protein:
Function:
Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Also transports other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively. In the skin, aids in the differentiation of keratinocytes in the epidermis (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLESLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSKGPLRALVLLLSLSFHSVFEGLAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAVFSILLLALMSPLGLAVGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELASPEAPLAKWSCVAAGFAFMAFIALWA
The following text describes a protein:
Function:
Component of the large ribosomal subunit.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm. Note=Detected on cytosolic polysomes.
Sequence:
MGVQYKLAVGLGKGHKVTKNEYKPRPSRRKGALSKHTRFVRDLIREVCGFAPFERRAMELLKVSKDKRALKFIKKRLGTHLRGKRKRDELSNVLVAQRKAAAHKEKTEHK
The following text describes a protein:
Function:
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR).
Subcellular Localization:
Nucleus.
Sequence:
WCVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPPCKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGQESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMSTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY
The following text describes a protein:
Function:
A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MRINSRMADDIESPVLSKATFYSDLNGTSKGEISLILSINPASVFLRASIQLLLCSFGFTEGLILQVFLDFAVLTLPLCLSVTLLSDGALHILLTEVALSFSLLFLAIQIKSTKHKYIPLKQLGQTPMEGRLPFITNFRVLNNIGVAVGILAVDFVVFPRRFAKTETFGTGIMDGGVGAYVLMNAIVSPEARGQYQRSGLKPIMKSLTSSLPLLVIGLGRLVSVKGIDYHEHVSEYGLHWNFFFTLAATKILCTLILLFTPVSWSAVISLSLAVGYQVLLTQHGLEDLVLHGTDLNDSREGFFNANREGLVSCLGYVAIYFAGVRLGQYLLQPRKIVSEWLKVLAYLLLADVILWITLKHVEARKGLTSRRLANLPYVIWNVAYCLHVLCGFLLIDIIMTIIRHHYLAKDKSRQLSLLVSAIGRNQLLYFLLANVLTGLVNLSIDTIHQPDVTAFGIVALYLFVLNFVLVFFHQKNISTKFW
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (By similarity). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
The following text describes a protein:
Function:
Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGLLAAIGVLLPFPFYWWLWTNAQSWVNLCGRERDPSTVMARVSHVLKAAQLLSLFSVASLSWPPPLYFWPLMAFGQFLNFRVYQLLGEAGTYYGVRFGKNIPWVTEFPFGVIRDPQYVGSIMSLLACLSWVPFQYILLWSLGYVFMMFLESKEDPNARAKSIS
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MESAHRDDDLSPEAARMLREMALRGREEGGEPDLPDEQLRSNDQLQQDEMLALEAIYGDKIRIFGEKAIPRSFQILVYCEIPDGINVYVEPFQGDDDDDTKSQFPENFSIEHLAPLSLTCLMPPSYPSHHPPYFTLGVQWLDNVQVSSLCHMLDLISAQQPEQEVVYEWVHWLQSSVLSHLGFDNGIVIRQPHSAVSQVDFRVVGEILSAESVVQQLISYNEDQCHESFLHGLHTCMICFSEYTGVDFVKLPCQHYFCQRCMETYSRIHVKEGTVLRLVCPDNKCGGIIPPNLLKKLLGDADFERWERLVLQKALDSMSDVAYCPRCGIACLGDKDNALCSNCLLNFCTHCRNLSHTGRTCIVLTPEEKLLTLQERAKVRRLSKGEVGMIISLANEIFSIKEVLRSSVPCPHCGIAITRVSGCNHMLCRKCGKQFDYDLAGRHNVRAVDFIKDVEVQKEARARLSASFKQHPCPKCHQPHHKVKLFWLFRYQSFSSFFHLALGNDFTDSLVLCEINTDSGMSRWGTTTTSCAWHAKFITVLCVGRWCGRAQSTMAPEGANSTLSTPCSLRLEQRTMMTLDQNLCETIQRESIGWGASVVLLQSLLDSVQHNVWEHQLYCCKAC
The following text describes a protein:
Function:
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
Subcellular Localization:
Secreted.
Sequence:
MKTMILLLCLLGSAQSLPKQLNPASGVPATKPTPGQVTPLPQQQPNQVFPSISLIPLTQLLTLGSDLPLFNPAAGPHGAHTLPFTLGPLNGQQQLQPQMLPIIVAQLGAQGALLSSEELPLASQIFTGLLIHPLFPGAIPPSGQAGTKPDVQNGVLPTRQAGAKAVNQGTTPGHVTTPGVTDDDDYEMSTPAGLRRATHTTEGTTIDPPNRTQ
The following text describes a protein:
Function:
May be involved in trafficking or stabilization of the vesicular acetylcholine transporter unc-17.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection. Synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Sequence:
MMSYIALAACIGLAMAANVDHDVKSAVNEVTTTKDGDTYCPVPLVGTKCGTSSIFHYWKCCGELNKECCFNLQTWVWVTLALFGVIFIASFVISLVRCICCRK
The following text describes a protein:
Function:
Catalyzes the conversion of ADP-glucose and inorganic phosphate (Pi) into glucose-1-phosphate and ADP. Does not possess galactose-1-phosphate uridylyltransferase activity.
Miscellaneous:
MISCELLANEOUS: Functions by a double-displacement chemical mechanism and ping-pong kinetics through a covalent nucleotidyl-enzyme intermediate.
Sequence:
MTSPSHASDRGGGDGDSVENQSPELRKDPVTNRWVIFSPARAKRPTDFKSKSPQNPNPKPSSCPFCIGREQECAPELFRVPDHDPNWKLRVIENLYPALSRNLETQSTQPETGTSRTIVGFGFHDVVIESPVHSIQLSDIDPVGIGDILIAYKKRINQIAQHDSINYIQVFKNQGASAGASMSHSHSQMMALPVVPPTVSSRLDGTKDYFEETGKCCLCEAKSKHFVIDESSHFVSVAPFAATYPFEIWIIPKDHSSHFHHLDDVKAVDLGGLLKLMLQKIAKQLNDPPYNYMIHTSPLKVTESQLPYTHWFLQIVPQLSGVGGFEIGTGCYINPVFPEDVAKVMREVSLT
The following text describes a protein:
Function:
Catalyzes the cleavage of sphingomyelin, a major lipid in eukaryotic cells, into ceramide and phosphocholine, which are then utilized by M.tuberculosis as carbon, nitrogen and phosphorus sources, respectively. Thus, enables M.tuberculosis to utilize sphingomyelin as a source of several essential nutrients for intracellular growth during infection. Furthermore, lyses erythrocytes and constitutes the main hemolytic factor of M.tuberculosis.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Domain:
Consists of a surface-exposed C-terminal sphingomyelinase domain and a putative outer membrane-spanning N-terminal channel domain able to mediate glucose and phosphocholine uptake across the outer membrane.
Sequence:
MDYAKRIGQVGALAVVLGVGAAVTTHAIGSAAPTDPSSSSTDSPVDACSPLGGSASSLAAIPGASVPQVGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVPEGGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTADPGFVGTDTFSVNVSDDTSLHVHGLAGYLGPFHGHDDVATVTVFVGNTPTDTISGDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAYYVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPFSDGLNTLSEFKVQRLDRQTWYECTSDNCLTLKGFTYSQMRLPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVTGDFNARYSDDQSALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKIFYRSGQGVTLQAVSYGNEAPKFFNSKGEPLSDHSPAVVGFHYVADNVAVR
The following text describes a protein:
Function:
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. McpK is a chemoreceptor that specifically binds and mediates chemotaxis to alpha-ketoglutarate (alphaKG).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYDWWVLQLAKLSVSRKLMVGFGVLLALLLLVVISSNRTLTHQTALSEQLAEVASLMEQTQQAEQGRLAFEAGSDPRQAEQVRQTLAGMLQRLQALRDSELDPAALAHQVEAIEAYRKAFDDLAAADQQRSAARGVLVGTAQQALDSFARLEELMDASLAQQAGDPQALQRSRAVADLHQQLLMVRYQVRGYVFERSDKAEQAAFAAFDALRQAATTLRGQLPGEADAALEQAMGSLQGYRGGIEQFRAGVIRTRQAQQAMQSSTQDMARAGRTLTEAGRQLRESTASRDRASLWLIAALALAFGCVAGWAINRQIVRPLDEALAQAEAIAAGDLGKRPQNPLTLQRRDELGQLQRVMQRMGDSLRELVGRISDGVSQLASSAEELSAVTEQTRAGVNSQKVETDQVATAMHEMAATVQDVARNAELASQAARQADEEARQGDAVVDQAVTRIERLASEMDVSSEAMARLKNESEQIGSVLDVIKSVAEQTNLLALNAAIEAARAGDAGRGFAVVADEVRGLAQRTQQSTAEIEGLIQRLQQGAGEAAERLENSRSLTASTVELARRAGAALDSITRTVSDIQNMNLQIATAAEQQSTVAEEINRSVLSVRDVAEQSAAASEQTAASSGELARLGTQLQAQVGRFRL
The following text describes a protein:
Function:
May belong to a complex set of multifingered proteins which play an important role in gene activation or regulation at early embryonic stages through a maximal accumulation of their transcripts (or protein product) in the mature oocyte.
Subcellular Localization:
Nucleus.
Sequence:
MEGGKGEGKRMKEEAPSKKLPPKIYGGDAGTPTKAAHDEILSSLLRINNFDSISSIKDESLDIDLSACVTISSASLVNGNSLSSTDFWRVLDESAQNNTELNLSSDVCRDDLAATSSSTVPSTLTSDNHSSSEFSVTFLRPEPPNAFTNSPFKKTSSSGTSTPVKLSPEQLHQQHQLQMPQSQLLQRKPKLPAATAVRLKVFKEEPPEEKHPPEQVVTKVEVCESELLPPSFTIFQQAKSAESVADAASMPPPAASETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRLTYRCSECQREFELLAGLKKHLKTHRTEGRKDTWKKCPDCGKCLKLGSMWMHRKIHSDNKKYQCDICGQKFVQKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHKTGEHLENIPSYCSKKSTTNKAQKAAAAAAAAAAASSAVNPNELSASSELKAKANLTSTAAPAPAKQARKKKQPQQATLAALGITLPAGTALQQVHPVPLAQQHQQELTTVLVPLAPPAPKQTKAKRERKQLAPKQLQQKPQLLQQGQPQQSSLEPIPAVPQIKKEPVQTQGPFLDLHGLSLTSAEELIMEQALEMEECGLYDAPNANTEMGTSDNAISDSAAALHFQIKNELPDELLPDDDFLPCKPSDRLPCPSLESSPFSSPASMELTAVSCASSVAISTNALPVRSGNYYLPAFTLNAHGKLSSTGNGVQSVTTSLAQTPSVSMVNVPLLVRSNQMLPSVDTLLFTNQTGGSRFFAGKSATAATPHLT
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSKWINKRKVSILNLAPPSKPGPALQATPVGEQEFEQLFHFAFKCFRLFALTPGLMDRQKDRYRVRNTRWMMLIVLLLVVVAWIALFETFFIERRTALITGIANHIQFLMNTIALTVAWVVPQLKADELGSILDGFLLIDRELSSYNVHEVAGYKRVSFLLRYGVVLLALMSLTVYDGFVSFVQLTTVEVWYWLSHQLPFIIYAMAFLHAYVLIYWLHARFRRLNTLVEQYYRQGHIFAPARQTIISFATMVKLDEESAVGEELHSVGRREISDDLQVLAIVSRTIDLGQKIESYFGPLFLTVYTALFSVTTIQSYYCYLHLTAKGDRGLSIETLVLSGGIILYNVIAIVALPYICEQVESESKLLMSYLSKLSMKHSQVAQHSSIWFPNLISSVRFSAFGFFTINYNMLSGLVAGMVTYLIIFIQFNSMVPAGKDDTHHTRKQHVTEERF
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Sequence:
MTTAHRPTFDPAKGKEALRGPAYHQRLLPAYTQLKFRKPGQGGVAGASEERDTRDLRAELLAAEEAHKAKLRGGPALTSGDDDVDNEKAGTKRPLALTGGDHNKEEEDQEAKRRRILELTREIDADDSSDDVDDDDADADDADAKSPKAQKNQDDDDASSDSSDSDSDSDSDSDDEEAELQRELERVRRERQEKREREELERQKAEEEQREKDIALGNPLLNKPDFTVKRRWDDDVVFKNQARGVDDRNKKKEFVNDLLRSDFHRRFMSKYVR
The following text describes a protein:
Function:
Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.
Sequence:
MGKSILLINGPNLNLLGTREPHIYGNTTLADVEASCKAHAESLGATLATFQSNHEGAIIDRIQAARGNVDGIIINPGAFTHTSVAIRDALLGVGIPFIELHVSNVHAREPWRHHSYFSDKAAGIIVGLGVYGYKVAVEHVALNFKERAAL
The following text describes a protein:
Function:
RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes predominantly to the nucleus.
Sequence:
MAAALGASGGAGAGDDDFDQFDKPGAERSWRRRAADEDWDSELEDDLLGEDLLSGKKNQSDLSDEELNDDLLQSDNEDEENFSSQGVTISLNATSGMVTSFELSDNTNDQSGEQESEYEQEQGEDELVYHKSDGSELYTQEYPEEGQYEGHEAELTEDQIEYVEEPEEEQLYTDEVLDIEINEPLDEFTGGMETLELQKDIKEESDEEEEDDEESGRLRFKTERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQHKQGRYSSRRGGRRGGPLMCRGVGDQRRESTERGRMKDHRPALLPTQPPVVPQAPPPPPPPPQQQPIRSLFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLETPRMMMTPPPVTPQQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFPGPPEFPQHTPGPVPNSFSQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPRFPSHLFLEQRSPPPPPPPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQQPVFPRERPVRPALQPPGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPTHTQPNLQGPLHPPLPPPHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQHPPQHQHHHHHHHLSVPPPPLMPMSQPQFRPHVQTAQPQASSSRMQCPQRQGLRHNTTSQNVSKRPMQQMQPTAPRNSNLRELPIAPSHVIEMSSSRCSATPSAQVKPIVSASPPSRAVAGSRSSQGKTEVKVKPASPVAQPKEEAKTETEFPDEDEETRLYRLKIEEQKRLREEILKQKELRRQQQAGARKKELLERLAQQQQQLYAPPPPAEQEEQALSPSPTNGNPLLPFPGAQVRQNVKNRLLVKNQDVSISNVQPKTSNFVPSSANMQYQGQQMKALKHLRQTRTVPQSQTQPLHKVLPIKPADVEEPAVPQTPRVASIQGRPQDTKPGVKRTVTHRTNSGGGDGPHISSKVRVIKLSGGGGESDGFFHPEGQPQRLPQPPEVGPQPARKVTLTRGGLQQPPHLPAGPHAHSPVPPGIKSIQGIHPAKKAIMHGRGRGVAGPMGRGRLMPNKQNLRVVECKPQPCVVSVEGLSSSTTDAQLKSLLMSVGPIQSLQMLPQQRKAIAKFKEPAHALAFQQKFHRHMIDLSHINVALIVE
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MWNSSPAASPNNNGGGARRKGKGRASAFASSGGFDEEGALKMFEDMCDEDDCTVAGMEGISKLCTLLSLDPYSDIRVLVLLWKLGASKKPAEIQREEWMAGCHRLNFDSLEKLRGLVPSLDMGFLDMEEFKDFYKFCFQFNRQGTHKTLDKDLVVALLKMTLADPPRIPTPRLTSFCDFLEQSTDESYAKITLDQWRSFLDFSLEFGSDEELLSGYDEGESAWPVLIDEYVEFVEKMSKGGKK