lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MMATSAIRIGDQLILEEDYDENYIPQENEIQEYARVIGIDPDSEPELMWLAREGIVAPLAATWKPCQDITGDIYYFNFETGQSTWEHPNDEHYQELVIQEREKLLMQGGGKKKEKKKKKEKKKDKKAKELPKPTLSLGSPLGPVQVSLGSLAPLRGLGDPGASGVTLGSLSSSAGSSGGFESLLGDAAGPHKSASLMKSSAVRRPDERVSLTLPGLDEEEEEDDGEQASEDLSPRGSARLLKNLHMDIGSLGGGFEYEESQRVEESPAASHTDDGSEPELQNLEKSDDEEESQKEESLDCQDENISPVSNVLSSGQGSDLDRGMVGSLGHTNSLTRESVGKRESSPSLQESDSKIKKQEGDASEHLTTSKTGEPGSVNEPPLTEQDSQDESEVSEGVKDVSGPAFKEKPVDVLLSGQLEEKVLGITALSSGAVREEKDIIEEEAEVEVEEDIEEEVSDEEVGQRRVLPKVTDRHINPGMDTLESVGVHKKLESSLNMSESPMLADLSSKPLLNQADHLAEDSPYKSVDRVSKNAEKCTVSEGESSSLKKESSKQADELPKLKEEFTKQPEEISSVILEQEEMELKMKQKQKLEELRETLRKEEEKESLEMHQCHENKLRALDECLDKQMQEEETEMRAAQKQRLLRLEKELEMEQEEEQEKLRLRMNELEEERKYTMKQFEKSQEEIILHEKAAIKEKMKPDIEEAIREEKMLLDKEKDAALDEMRQKLKQEMKEALEALEKQHAQELENLKAEAEQNHQQTVSELQNLRLQQKEAQTFSELSHSNNKMLQLMDFEKDMSDLLQEKRLEVQRDHERKLERLKEDHQQELERVRDQLEEEERTQRSRMLKRLQEQLEKIRRLHEEELETERQELQRQQEERRNSYQEKENKLQDLEQSLEFRRNQLVKKTGQLDSQEENIRQRRENMEEKEKELARRTEEMKHSSLNLKIQEDLVAEQKQLQDLIQKSQHEFEKTQNQRTELETEVERLQSRYSQLLNKVRDLEEEIAKSNIDLRDDTVRVSPRVDPALRLEDLTAYTSSVHGASVPHLDILRHAMSSVQNQDNDSEMDDIQHYISSQGASVQKAKDFLHLQTRSLCHRQSLLHAAKKNWRHSMRETQDLHLLQDEKQNLEEEARSINAFQSTMQKGQVLLQEKEQRLQELESSLREEISDDDAVIRGRRSKKVVSFDLSDSDDSCSIINNDLHPGGDLRTQPIVPFKVHSLTDSLRRITAELNGVLSSLGSLSNDPLSTEPGIPLSSFNTLTRLSVPQSSVWSSSLPSSVPSVPSSSQSVDAILMKKWQKYFPGGTPPFSNQSQLQENRFGYVPAGDQVQMLQSSAVHAQHTDKRSIQAMIDTNKKWLENFRNDPKVPRTSRTMGSSPGLLQLGLDENNQIKVYRY
The following text describes a protein:
Function:
Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSISSDTSGSVPGSPIDLEPESETICHWQSCEQDLLTLDNLVHHIHNGTTSNLRLISNINSILDHIGNRRPKYTCEWDDCPRKGMVQTSRFALVAHLRSHTGEKPFICSVPECDRSFTRSDALAKHMRTVHEADTLRPSDPIPKAHPMHPQNVANAMVQSAREARAQQQMHGVGNTNEDVENWLDAASMPKTSHDMYRLQKRKLQWVKEERTMLANHLEALERKLIDARNRKEKILNEIVKQVDPSISR
The following text describes a protein:
Function:
In vitro, the triap1:prelid3a complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MRIWSSEHVFSHPWDTVIKAAMRKYPNPMNPCVVGVDVVDRNLDSQGRLHSQRLLCTEWGLPSLVRAILGTSRTLTYIKEHSVVDPVEKKMVLCSTNISLTNLVSVDERLVYTPHPENPEQTVLTQEAIITVKGVSLSSYLEGLMASTISSNARKGWDAIEWIIQNSESTVS
The following text describes a protein:
Function:
Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MGPETFLRRARDQDFLRQGNRQSSASGCPVAVVTARITALVIMAVLSGAQIPDGEFTVVVYRLIRDARYAEAVQLLGREPQQSPRSRAGLSLLGYCYYRLQEFALAAECYEQLGQLHPELEQYRLYQAQALYKACLYPEATRVAFLLLDNPAYHSRVLRLQAAIKYSEGDLPGSRILVEQLLSGEEGEESGGENETDGQVSLGCLLYREGQYEAACSKFFAALQASGYQPDLSYNLALAYYSSRQYASALKHIAEIIERGIRQHPELGVGMTTEGIDVRSVGNTLVLHQTALVEAFNLKAAIEYQLRNYEAAQEALTDMPPRAEEELDPVTLHNQALMNMDARPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLIYKFLTPYLYDFLDAVITCQTAPEEAFIKLDGLAGMLTEVLRKLTIQVQEARHNRDDEAIKKAVNEYDETMEKYIPVLMAQAKIYWNLENYPMVEKIFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKHYDNILNVSAIVLANLCVSYIMTSQNEEAEELMRKIEKEEEQLSYDNPNRKMYHLCIVNLVIGTLYCAKGNYEFGISRVIKSLEPYNKKLGTDTWYYAKRCFLSLLENMSKHTIMLRDSVIQECVQFLEHCELHGRNIPAVIEQPLEEERMHVGKNTVTDESRQLKALIYEIIGWNI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that acts as a regulator of cell death and defense. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Attenuates the activation of defense and related cell death responses in the absence of pathogens by mediating ubiquitination and subsequent proteasomal degradation of MYB30.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEASPNDRLHFGKMGFGCKHYKRRCQIRAPCCNEVFDCRHCHNESTSTLRNIYDRHDLVRQDVKQVICSVCDTEQPAAQVCSNCGVNMGEYFCSICIFYDDDTEKQQFHCDDCGICRVGGRENFFHCKKCGSCYAVGLRNNHRCVENSMRHHCPICYEYLFDSLKDTNVMKCGHTMHVECYNEMIKRDKFCCPICSRSVIDMSKTWQRLDEEIEATAMPSDYRDKKVWILCNDCNDTTEVHFHIIGQKCGHCRSYNTRAIAPPVLPQ
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MKRLKKCTCLYHSGSSSKEIREKFLDFFAKEHLHSRVPSSSVVPYGDPSLAFVNAGMNQFKPIFLGQAAPQHQRAVNSQKCIRVGGKHNDLDDVGRDGYHHTFFEMLGSWSFNDYFKKEACSMAWQLLTQVYRIPPQKLFITYFGGNQSLGLPSDEECREIWLSLGVAADHILPFGMKDNFWEMGLVGPCGPCSEIHVNKANLETSLARTLVNQGTEEVVEIWNLVFMQYNRISNQVLEKLPAHHIDTGMGLERLVAFLQNKNSNYDTDLFLPLIDAVHQISGGVPYQGSYDMQSAQGQRDWAYRLLADHSRMITVALADGAFPDNNHRLRRVMRQAMVTSRKWFNQDASLLLELSQRVADMMGGVYPELSRNLSNVHMLLRFEEDIFRDHLAKSGREWSAIVNQFPELSALPTDQQPGLIAGLRQLEDWRRSSGSDKISGSLAFKLYSTHGLQEDSLQLLVQLKGWNVDWPQFHQLMADERMSTKIQSSAAVSSQFQCATSLKVAPTVWQCQDVCSRNAEGHYTFKPFDATVTALVSQDGRTIEEAATGDRVAVIADKSCFYYEAGGQVSDTGRLLWPTGAGQVEEIRRVGDHIYHLIKVNEGNLRVNQTVQMMLDEDNRLNTMANHTATHLLHAAIKDILKVTCQKSSYVTPEHFRFEFGLFQSEFTLEMISQAESSVRNWICQRLAVDRLMLPLHQAVSLDGITLVPGESYPDMVSVIRVAQESGKDEAISLEPCCGTHVRNTADLEEFAILSVKSAGIGSRSVRAVTRATAKQSLCRADDLKRELNLLEEMVNKFNAVEFTQLKELDKTLKQLRETISSDDVPLIVNKELSFRLEKLESYVRQAAQETLARLMQHQVESAVSHAGPASFVIVYLSIPHEMLDIGRAKLSLIKATRHCPHKPILVLASDDGCLIGRCTFPQEMVTGDFDAEKWSGYVIRAIGGKGSSPKGQDPRFNYNIRSRKLVNDSEESVRQQALSLATQYAKSRSL
The following text describes a protein:
Function:
Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces.
Sequence:
MNKYKPVPKLSSQSPVHHTNLRIPPSGRPFKKEDFLNLISKDSLESDSESLPQEAKSWSDIKDQIQDKDMEPDSLEEDSPSETEEAVNRKAAHNTNREDLSAHDAGVNHSQHQVEDKYSDLRYDPNWKNKREEGQPLAGEALPGSADSSSENLPLAPLYPSREPSMGLSAGKGKEKKSPQSEASLLGSEFLSPKYERSTRQNGFFSELSDSDQEEKSSGLSQYLKSSSSHNDVFLPGSRGPRRRKSKQYFVEKNKLTLGLPMPKTDSYLQLHNKKRGETRLEQISYPVRDTDKMTVQNDKEVENTFMDPEDKWHQRAKQLKNYQEHLSQYEDTKSGNVPRGQSSDAANGQQPSRRTAKARVRKQRKHQKGLKSLGTKELVVSQNNQNNPFQQPQNQRQTADASAKHELAAQTNASNPNLQDARTLTHNPKVTSDSFVSPKQALDRALYKNSISGLNANKRRGHRREEERILYQPQPIYVFSDTHLQDFNELPHRHESPSQRAPQSDHHMNTHRSTKTKKPAKQPQAETKYKNIEMLWKFHSSSDMEPASASPDSRLAQIMEQHQQALMQLAEVQPSEGSLASIILPPILSRVESESQLNSERSHRHQVKMARSNSEGYLLQLERGKRHRKRSSTKSSKLKGYQKRDVKLGGLGPDFASVRDKMQMLMQQKEYAQQVKDYNMKALSILSKPQTSKTESKSAISRKKALDYAKTIPKPKPPNLPDQTAKKTKNSRHSEKEGGLPEISLLEILQSRHEREKQAVAAFKVLHIV
The following text describes a protein:
Function:
Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells.
Subcellular Localization:
Cytoplasm, cell cortex. Note=Localizes to the medial ring at the cell cortex of dividing cells.
Sequence:
MASMVLADGMPTVKDDSTRSRGSDVDSFTSTDNVTQINVEAAISENKNEEKPIQDNSEQEFNPHVSIIQRQLNGYVGFASLPNQWHRRCVRQGFNFNVLVLGESGSGKSTLVNTLLNRDVYPPTQKSLTGDFGVNPEPTVMINSSAVEIVENGISLQLNVIDTPGFGDFIDNTDCWQPVLTDIEGRYDQYLELEKHNPRSTIQDPRVHACIFFIQPTGHAISAMELRVMLALHEKVNIIPIIAKADTLTDDELNFTKEMILRDIQYHNIRIFFPPTYETDDPESVAENADIMSRIPFAIIASNTFVVNNEGKRVRGRRYPWGVVEVDNEEHSDFPKLREMLIRTHLEELKEQTNKLYEAYRTERLLSSGISQDHSVFREVNPSAKLEEERALHEEKLMKMEAEMKTIFSQKVQEKEDRLKQSENELRTRHREMKAALEKQKADLIDHKNRLMQAKAAAENEKSKRKFFK
The following text describes a protein:
Function:
Inactive FRIGIDA-like 2 protein.
Miscellaneous:
MISCELLANEOUS: In cv. Columbia and cv. Landsberg erecta, either FRL1 or FRL2, but not both, is functional and required for FRI-mediated up-regulation of FLC.
Sequence:
MTAAESIAASINQIDEKKQKLKKAFDDLQAHRSLLSPSFNLSWSEIDSHFSSLQSSLFNRLQSAVTSSNSGNIETPTAVTTETPVLWPELRKFCEKNDGKGLGNYMIENSRKRLSINEELPNAIRCSENPAPLVLDAIEGSYHCSSPSSSSSARAIDVKRIFVLLLEALIEINANLTNDLRERARTIAYDWKPNIGNKPSEALGFLHLVAAFELGSLFSTEEICDYIFLISKYKQATTICKKIGLDRNRIGVLVQKFLDTGRLLVAIRFIYENEMVGEFEPVSILKTSLKNSREAAKRVCAEGNYSLKVQNEATDKELSALRAVIKVVKEKNIESEFMEEKLEECVKELEDQKAQRKRATKFNSPANPQQPQEQKVDNKRPRVANGSSMEYNLTIPPLRPQQQPPLLPTPSQILQVNPYGLLSSILPGVAVPYGNPRALFGSVPAPASRPVFYVQQTGYGMPPPQYRPPYYPQ
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor family.
Subcellular Localization:
Cell membrane. Endosome membrane; Peripheral membrane protein.
Domain:
PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes; The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.
Sequence:
MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTVSFFNEASYKSFTKFFFFRDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLSISKFGPGDQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGNLCLFLKRIIHIKLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly by promoting the functional integration of the U4/U6.U5 tri-snRNP particle into the U1-, U2-dependent pre-spliceosome. Also recruits PRP19 to the spliceosome, as a component of the NTC complex (or PRP19-associated complex). The association of the NTC complex to the spliceosome mediates conformational rearrangement or stabilizes the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Required for initiation of the DNA replication by binding the RNA replication origins, probably through its interaction with the origin recognition complex (ORC).
Miscellaneous:
MISCELLANEOUS: Present with 2140 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIFPDDIDDDKPKPSKFLELAKKWKQEQAL
The following text describes a protein:
Function:
Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=Microtubules. In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip.
Sequence:
MNESVAKKTQETLGKVIKKPPLTEKLLSKPPFRYLHDIFSEVIRTTGFMKGLYVEAEMKSDNVKDKDSKIAFLQKAIDVVMLVSGEPLAAKPARIVAGHEPEKTNELLQVIAKCCLNKLSSDEAVKRVLAGDKLDQKGKPSTSRSQDKENREGREHHRDREERKGIKESSGSREQKDPDQPKDQESKRDDKDRRRDAERSDKGRERERTKDRDRDKDKSRDREKDKTREKEREREKDRNREKERERDKDRDKKKERESHKDRERDKDREREKRREKEKDKERPRETEEKLKDRGDRKIKAAEEISKSKPQPEVASRTHQAETEEAESPSRIPRPSSAKGQRRKPKTGGQGTEQDETESEGEAEGPSAEKPIPLENGDVTDPAALQTTHSRRLPRPSSARPAAPRVKRQESYTDATPAERLGSGKTPASVILDGKKLSEDEDDEDGQFVVEEAAPPPSDVPEVESNSLELQGDDKHGGLVKKILETKKDYESSPSSKSKEQDRSLVSEASRKKERELVAREIERLRSSIQTVCRSALPLGKIMDYIQEDMDSMQNELQSWRKENKENAQALLQEQRITDGVVEPLKVELAELEQLIKDQQDKICAVKSNILKNEEKIQKMVSSISFSSQT
The following text describes a protein:
Function:
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Colocalizes with both, alpha- and gamma-tubulin (By similarity). Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta.
Sequence:
MEAPLVSLDEEFEDIRPCCTEDPEEKPQSLYGTSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLRDEEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDTEIHEKEEEDEFIEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEVEVLEEEDGGEISSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSSDSEDLDEDELLQMALKEQQQRDVNYLTNSRKPVANYVQPPSQSRKSASAASVSKTTGSSAQSKGARRVVDDDDDSEVEMLSISSGDEDSTRDHRTSAATRGGRASRSTGKEDDAGWDGEEPHCWKHVDEDELARRVREMRETRTAPAPQKFDRKVSAIGRPGLNHLQSFPRGMECIDPLGLGVIDNRSLRLITETSESSPSKSEKEFIDATLREKLLYFSEKFDAKLFISRIHQDTSAGDLDKGAFALKTDLKGRTQQRKQLVKDNFDCFVSCKTTIDDIESKLRRIEEDPEGSGTSHLFNCIQGVSKQANRAFQSLFERQAQAEKIRSVQGMLQRFRTLFNLPSTIRSSISKGEYDLAVREYKKAKSIALPSHVGILKKVLEEVEKVMHEFKGTLYKSMEDPRIDLTNLENTVRLLLELEPESDPVWHYLNIQNHKIRGLLEKCTLDHESRMEALNNKMRERALADARWRQIQHDLDQSSDVDHSSSVDGHLPVGVEPVEVHSEEVDALRARYIKRMTAVLIHHIPVFWKTAHSVFSGKFAKSSQVSAESNTNTSASKAEDKVGEGKYSNHSLEEVTGMIRNTLSAYEVKVHSTFRELEESNILQPYMSDAISEISNACQAFEVKESAPPSAVIALRTLQSEVTKIYILRLCSWMRASIVNISKDETWVPVSIIERNKSPYTISFLPLAFRSIMSSAMDQINFMVQSLTSEASKSEDIFLLLQEIEESVRLAFLNCFLDFAGHLENIGSGLTHKQNKDSPHLQNGFSHELQEKLLLDVPGSLVNPHQQLLIVLSNIGFCKDELSCELYGKYKHIWSHSRIKSEEDTSDLQDLVMSFSALEEKVLEQYTYAKVLPKSILNLRN
The following text describes a protein:
Function:
May be involved in the synthesis of very long chain fatty acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDLTGAHMLKIHRPSIDHPFGVDLWHLFEQLSIKTIGWNPSEFEYIPGKTPMSQWSSVIVSITAYYVIILSGRAIMTNRKPLKQRRLFQLHNFILTIISGALLALLVEEVFRNYMRNGLFYCVCDSRHFTQRLVTLYYLNYLTKYLELMDTVFLFLKKKPLAFLHCYHHGITALLCFTQLLGRTSVQWGVIGLNLYVHVIMYSYYFLAACGRRVWWKQWVTRVQIIQFVLDLILCYFGTYSHIAFRYFPWLPHVGDCSGSLFAAFFGCGVLSSYLFLFIGFYINTYIKRGAKKNQRKAAGKADNTSVAAAAGSEALAATTATNASPFSARSRKL
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MALSLVNVRSLLCRSANTGTKGFMSSPIRLRRSIRLSNCLSTSPYCYNHSRLSSRERTEAFAWLGDLVPVFGTTGNKVSVLHDPTVFFNVLKGRIWTAEKRIVLSSLYLGNGPLEQELVAALHTQLERVRDLQVTVLLDYTRGSRGTNNSRTLLLPLLQNFPDRVQVSLYHTPDLRGLLKAVVPERFNETIGLQHMKIYLTDNSVIMSGANLSEIYFTNRQDRYIVLHNIPLLADMLANLVSCVASFSFQLCRDNSVTLHPSFNIHPYKDDIDKFKSEARRRVMDLLKPGYFTKLSDPFFTDAPFRHRKKVIGWKRELRERSIQIYDGDDYTSHYEVEGRDEESDEEMQLLIQQGAWVMVDTRTKEKTVVHPDSSNVTQLKRTIYVDTWICPLVQMGPLGVWHDEMVTRRLLRTAPKESELLLASGYFNLTEDYMNVMLQADADFNILMASPQVNGFYGAKGIAGSIPTGYTYIAREFHRRVWQQAQQDRIRLQEYIRNNWTFHGKGLWFYHPGEDLPSLTLVGSPNFGYRSVHRDLEAQLAIVTDNWALRQQLHQEQRHLYQGTEEVTKETFQRPDRQVPSWAKALTRVIKNFF
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHLKEILAQFSFFTAIPVKSSASLEEIAESSYISPIIVGISLGLIESVAYLILYRILGELTGIVLLGIIELLRGFNHLDGLLDLGDALMIRGNREKKIKALKDVEVGSGGIGLLLVYLSIQIVALLKLDFSLYTIFYLISSNVLSMSLSLYILSTISPIPESNLGRIFHDKLKGKSTILLLELIPFISLYNVIVFIIFYMIMYKICGSLGGSSGDIAGASITLSFPLFLITDEITNLNYSLLSILCYLFSHLH
The following text describes a protein:
Function:
Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDGQGEKGTVACSKDEAAMDSYLRSEGLYRKKIAKDGSCLFRAVAEQVMHSQSEHLKIRKSCINYLRENRGQYEAFIEGSFEDYLKSLENPQEWVGQVEISALSLMFKKDFIIYQEPNIPPACVTENGFSEKIMLCFSNGNHYDIIYPIGFAESAAMCQSIIYELLYEKVMKINVGKYVVDEDTFSPTTTEEIYCSDGSESEAEDISKNIKTNFADMNGFNSNKDDKCPQKKTIEPTILPSVLRSLHTSHYRNVEHEVWLKTQRDQQKLDFSIAAGMQYSVGDKCQVRVEPGGKFYNAHIQEVGAENGPVIVFVEELGDKHAVQLKNLKPIPQTIVSTDGWNTVAGKKQKKALPSGTNTQPEKDCRGQKGFGKPVKQQATQPLRLQQAAANKQHGLASQLSDQAPQSENKGRSRTPPKVPGRKVDRERSEESNYFKRENVTFGFTIEERKEKEAIEESKSLYEMQSMDKDAFPALSSLPKGERTVQNTEVFPVKRTNLITENPKKKSDGEDLKDKGFISNASTAQATKIGDQKSSEEAVKQFTPSDADDLSSAPVLPTSAEPQASPTVPSTPPVITSWPAEIPSMPATGTDSSLLQPQVTSSPYPPLPVSMPAVNQPLLPLPQALGALQDPLYPGFPLNDKGERATVPSYSFCKNGEDLPDDKSILRFFFNLGLKAYTNPMWPPHSHLYPLHQAYVTMCRIYPAYPQGSVYPQGSWVEETSANQSEVDPSILAHPNEVRMESHCSQPATVSSPPVVASPVLVPGIVGQIPNPSESGVINQALHTNVTFEEPATSKTIFPQPQFGQSSYMGAVPIASSYFPHYWYGYPYQGYIESPVIRQNVYIPPQDRDLSESLSSEAVVKNNSANQIAIRQSVDLQEQCKPDLPLASSAGGIGTELISNASTVQSEQKMNVNITQVLTGNKSLPSKIKDNQVPPLAFTQVETREPASVASEDKELSEKEVNAGALGSTQIKVSEEKALSSEDEREVSSMLRSGRSKNFYSQSYNTRRPRSEKYYQPNRGGYQHGRGEESWRGQRGRDDGFQQYRGYRGRPYRRRPMGNSYRAQQE
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MDESSQQGQDRSSSASIPTLPLHHEILQSWGMDALCLTQEFKIIVSTVQYTKHSTTCSVCELLTLRQILKLETGDGPSAEKRIEKPNNETFVSLNHSIDAANQSEAWNASRSHTPINSSNTYIAPVQTYYYGGYDDGLINWGEGSNYVHTNNLQIMSPAIYNDNSSLLYHPAFTYDTQIAYAQFPQIASQLSPIMIDGQLYSPHQLPISPSYYSQPISPTDYYLQYPRNNNLGFYKFPNEITQCEPVSTQSNPVGILGPYHGSYEATRVDKNMDRVDSVSLSATTSDRNRGPRALKPKGTTTGEHMSNEDFVTSYEKAKFFVIKSFSEDNVHRSIKYGVWASTPLGNRKLDAAFKEAKEYASRVFLFFSVNASGQFCGVAEMIGGVDFEKDADYWQQDRWSGQFRVKWHIIKDVPNSRFRHILLENNDNKPVTHSRDSQEVKLEEGNTMLKIFKEHDADTSILDDFNFYDEREKSLQEKRTKEQVFSTKNTIDDASINRLSDRVANSLQLENQNEVTKS
The following text describes a protein:
Function:
Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.
Subcellular Localization:
Host cytoplasm.
Domain:
The BTB domain is responsible for the interaction with CUL3 while the Kelch repeat domains supposely serve to recruit the cellular substrates.
Sequence:
MNNSSELIAVINGFRNSGRFCDISIVINDERINAHKLILSGASEYFSILFSNNFIDSNEYEVNLSHLDYQSVNDLIDYIYGIPLSLTNDNVKYILSTADFLQIGSAITECENYILKNLCSKNCIDFYIYADKYNNKKIESASFNTILQNILRLINDENFKYLTEESMIKILSDDMLNIKNEDFAPLILIKWLESTQQSCTVELLRCLRISLLSPQVIKSLYSHQLVSSIYECITFLNNIAFLDESFPRYHSIELISIGISNSHDKISINCYNHKKNTWEMISSRRYRCSFAVAVLDNIIYMMGGYDQSPYRSSKVIAYNTCTNSWIYDIPELKYPRSNCGGLADDEYIYCIGGIRDQDSSLTSSIDKWKPSKPYWQKYAKMREPKCDMGVAMLNGLIYVMGGIVKGDTCTDALESLSEDGWMKHQRLPIKMSNMSTIVHDGKIYISGGYNNSSVVNVISNLVLSYNPIYDEWTKLSSLNIPRINPALWSAHNKLYVGGGISDDVRTNTSETYDKEKDCWTLDNGHVLPRNYIMYKCEPIKHKYPLEKTQYTNDFLKYLESFIGS
The following text describes a protein:
Function:
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Also has phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Sequence:
MEMQDLTSPHSRLSGSSESPSGPKLDSSHINSTSMTPNGTEVKTEPMSSSEIASTAADGSLDSFSGSALGSSSFSPRPAHPFSPPQIYPSKSYPHILPTPSSQTMAAYGQTQFTTGMQQATAYATYPQPGQPYGISSYGALWAGIKTESGLSQSQSPGQTGFLSYGTSFGTPQPGQAPYSYQMQGSSFTTSSGLYSGNNSLTNSSGFNSSQQDYPSYPGFGQGQYAQYYNSSPYPAHYMTSSNTSPTTPSTNATYQLQEPPSGVTSQAVTDPTAEYSTIHSPSTPIKETDSERLRRGSDGKSRGRGRRNNNPSPPPDSDLERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSANLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYGLGIVFPIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKKHAMPFWRVSSHSDLMALHHALELEYL
The following text describes a protein:
Function:
Plays a role in ribosome biogenesis and in nuclear import of the 60S ribosomal protein L5/large ribosomal subunit protein uL18 (RPL5). Required for proper erythrocyte maturation.
Sequence:
MGKSRTKRFKRPQFSPTGDCQAEAAAANGTEPEEDDGPAAELLEKLQHPSAEVRECACAGLARLVQQRPVLPSLARRDAVRRLGPLLLDPSLAVRETATGALRNLSACGGFEVCDDMVTKDIMTPLVALLKECSTGLDSNEMSPQKKKDQNKNSIENIANEAINVLWNICECSSRAVSIFNKEGCLEIVLKYLSRFSTNVDLAISVAYCLQTVTEDNPELLKSFSTPALHVLESAMLSPVSSMEYLLLKTLVAGTVWNLKDIIPSKSQAEIINAILKILSEVLEMDAGETVIQMKEAETQRIKTAAETEDTLQSANGDDLMEDEEMEEIPHRRKVRRKTFISDLLPPTDKELRETIALLTAQQTALEIIVNMCCSEDPTDDEWEELSSSDESDAFMENALSECGGQLLSPLCLSHEVHTALTHHLLPKKIFDKTAFPNSVAVDVCSRSPTWKPLIRKMNTIQCRALVCLQSLVSLLDVDHLGGPAALQTLAQHLSQLLFSQPDFAKHVDFLEAISSALRALLQTMASKNIPQCMTPDQLMTLCTAGVRSSNVGVRVNVVSILGITGSVLAKEDGTLDTLKTIGYSLLEVATKDPCLVVAGEALDALFDVFADGKEAERASVQIKLLSTLKEFQPVFKMKIRKEGRTKYSPDQLCVLDNVKMNLRRFVAYQETVEKRLTT
The following text describes a protein:
Function:
Part of a potassium transport system.
Sequence:
MRVSCLSLPWHTPKALLHETITQTYLLWHIVLEHMDIVIVGAGRVGSRTARVVTNEDHAVTVIEQDYDRAERARTEGFDVVEGDGTSEDTLLDAGIDTADAIGALTSDLNTNFIACMVGNHHDCRTVLRIDEDYREDIYRKYADEVDEIVYPERLGAIGAKNALLGGNVTAIADLAEHLQVVQLTVTDEAPMRGYSISELELPAGARLLAFGKHDASLALPLPSETLETGDRIAVLAEFDTLDSVRQILVGNAPPTEVA