lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NADH-dependent flavin oxidoreductase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. IccE acts as an epimerase and catalyzes the conversion of 8-epi-ilicicolin H into the final product ilicicolin H. The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iccA with the partnering trans-enoyl reductase iccB since iccA lacks a designated enoylreductase (ER) domain. The cytochrome P450 monooxygenase iccC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone. The pericyclase iccD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H. Finally, the epimerase iccE converts 8-epi-ilicicolin H into ilicicolin H via epimerization. IccA to iccE are sufficient for ilicicolin H biosynthesis and the roles of the remaining enzymes, iccF, iccG and iccH within the pathway have still to be determined (Probable).
Sequence:
MADLHLAKSITLRCGLTLPNRLAKTAIAESIAPRNMLIDEGFHRVYAPWAEGGWGMVLTGHVQVDSMHLGTHTDPAVNADFSDDQIVGSWKVWAAVCNRHGTPTIMQLNHPGRQAPIGAGTSGVFAKNISASAVPMDIGSGLLARAVSKIVFGTPREMTVDDIGKLVRQFARAARLASQSGFAGVELHASHGYLLAQFLSAATNRRKDAYGGTPANRARIVVEIIKAVRAEVPASFCVGIILTAVHGSASTEEFQSFIEQAQLICDAGVDFIEISGGTFETPSMFIGPEKRGKAYDWDNQEAFFLDFAQAIRPHLGTVPLLLTGGFRSCHAMEAAVKRGDCDMIGLARPAVVNPLLPKTVVFNPEVNKSGDTKLHATRTPAPWYIKLFGITALNVHMDNAWYVGRLQTLAKTGR
The following text describes a protein:
Function:
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.
Sequence:
MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF
The following text describes a protein:
Function:
Plays a role in thermal stress response and in aging.
Subcellular Localization:
Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Note=Cytoplasmic localization is regulated by wts-1 and ftt-2. Localizes in the cytoplasm when phosphorylated at Ser-104. Transient nuclear localization in hypodermal cells upon heat shock treatment. Nuclear export after heat shock treatment is regulated by wts-1, ftt-2, hsf-1 and daf-21. During the embryonic development of dorsal epithelial cells, localizes transiently in the nucleus. Mainly cytoplasmic during embryo elongation. Localizes to the base of the cilium.
Sequence:
MASKSIHKKHQENSQQDKNQFSVHHYLDPNQSIHALISCSEKKYEKNQNQKKNPLPSSYYHQKRNPGSSAHSPYGSVDESSRTAVSPAMDMVSNQAPIHTRQVSAPNLHTSVNNGQSSATVPHPSHHNVHHQHSKSVSALPMTIGYSPVPSHVKSVSHEANYSYAGLSEIPQQQGMMQQNREKSLSLDPMRRPFMTPQDVEQLPMPQGWEMCYDSDGVRYFKDHNSKTTTWDDPRLKQQEQTGFGLGENIGQNRYNNCYDNGHSSRSLPSIHQHQQMIPNHPQPQYSSQQQMDYIQQLQNERMMIQEKNAQLINSGLVDSPQPPYQAISPMSSTMMHSHDPNFMYQQQQQAQNSQQQQTPHTLHQIPNQYQNSQMNDDSAMEVDYSMVSHPQQLQHQHQPHMHNNMPSNYVIDDINPHEFDQYLQISNDNNRGVGSMVHHYQ
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Sequence:
MSEICSTSCWQYAIDNPNCFPKIGFTKVCFMSGNYTCASSSGFTILSDELSFINYGLYHPDEIIGKFIKIKGNEYKVTKATNSIINLSNSKNGRGIFIYRSPPLLFIGVYNDAFRLHVYQREEWFKNIQEIINGVVFSITIGTTSKVHEIFKNKNNNKR
The following text describes a protein:
Function:
Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and may play a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the epimerization of L-Ala-D-Asp, L-Ala-L-Glu, L-Ala-L-Ser, L-Ala-L-Pro, L-Ala-L-L-Val, L-Ala-L-Thr, L-Ala-L-Leu, L-Ala-L-Ile and L-Gly-L-Glu (in vitro).
Miscellaneous:
MISCELLANEOUS: Part of a large, functionally divergent protein family. Protein modeling and substrate docking were used to predict the substrate specificity, prior to biochemical analysis.
Sequence:
MPNRRDFLKTAAFATLGSGIAVSQVLAGECMPSAIHINKYGIGGKMKMTFFPYELKLRHVFTVATYSRTTTPDVQVEIEYEGVTGYGEASMPPYLGETVESVMNFLKKVNLEQFSDPFQLEDILSYVDSLSPKDTAAKAAVDIALHDLVGKLLGAPWYKIWGLNKEKTPSTTFTIGIDTPDVVRAKTKECAGLFNILKVKLGRDNDKEMIETIRSVTDLPIAVDANQGWKDRQYALDMIHWLKEKGIVMIEQPMPKEQLDDIAWVTQQSPLPVFADESLQRLGDVAALKGAFTGINIKLMKCTGMREAWKMVTLAHALGMRVMVGCMTETSCAISAASQFSPAVDFADLDGNLLISNDRFKGVEVVNGKITLNDLPGIGVMKI
The following text describes a protein:
Function:
May be involved in spermatogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDSQRKHAGSKGFRALENRKQDIAYNHYLNSFVKLEDRRYLPNDNVIHQLVPLRAAVGTIVMTPTQFNEVHFSPLGTCFYFSENNVPNDPLTMALLEREKLNATKTISTIVFVSTRDSKGFNISGYIDLEHSLRRYKTAGSKSHPWADIFAGRRRLEPNHQDLSFINWSNGRVHSNDSDNYKVIPDAVKGLCFAHKGDGSMLSIEKYITEEHPLCKFIESPKHGYTVVYDHYIRRKM
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Sequence:
MALNQALRNFLKSKNRQEPASFIHLFELYTSLEHDPHEEKALPKFLKELNRKKTEEERLDFMYNVLQKYNLFRNKFTRDRKRDEHAEHCKLEGNVYFSEGNYSFALGFYTKALMGANGPEMLAICYANRSAALLKLGLYEECLIDIKRAIDHNYPERLRPKLMSRRVKAVALKRKQKFESTYYEEAPKIPTSQRNNSIPCATNSVEIKVDEKLRKRVVATKDIQIGQVIAVETPCVAALINVVLFHCHDCYILCYNPIPCKTCTEVVYCSEACRENAFAKYHQKECPIYLSMRKLVGIDTHFQWALKMTLLVQTQADKCCDRIDTDDDRTRKTLMATLFYHLIKNCTTVLAGVDEAGVKNFKRVLMSYMHICDYHVSDIDEIFVHGGSRDLELKQETFAKAMYPFSDKLRHSCCPNVMGWYHGVTRVLRAIRTIKKGEECFFSYGPLYTNIEKEERQNYIFFIYNFKCACRACKQNWPQTESVPRVAIEDHMFLYTRKRFDVDAAKMLINRKIDLMKQLERSEPNDELINQQEMLFHCFYILGNKRAFQSQLLACVQDDTRNSGEFVRDFHKLGSNVEKVDFLYERMRQYGLLDDKFTKDEKDDKKAKKHKEKGDKFFATGAFSKALQSYTRSVMKAKSSEALAMAYANRSAALFKLEQFEEALTDVERALSGDYPENLRPSLVTRREKLLGFMGAHGPAFNFFESVPEIPEEQKNASIPSASSCIEIKPDEKSRRRVFAARKIEIGEIIAVEKPFVFTLAAADLYHCHECYQLCYNPIPCEICSQTLYCGEECRDKAREKYHQYECPILISLKNIVGKHKAFLLAIKMSFMISDENDVPEVYALVENLSRDNNDEVFTTALITALMYHLVKTYTGKFPEDDLEAENKFKHFLMTHLRICLTHAAGIDELYPNQVSEGQEPGQELLSFKSETVGCALYPFYALFRHACCPNVFAHHHGTQRVLRAVRTIHEGQECFVSYGPYYVEHSKQERKSRLLSQYHFTCKCRACEEDWPQLDLNPYYLTSKQDLDFVAKIRNANIEAAVEEIPRFLERLKGLEVFEPLSELTLQQKLLSYCFDMLGNKRRIL
The following text describes a protein:
Function:
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Sequence:
MLKSRVILAMDKPLSYQVLKEMENELYGIKVGLPLVLDLGVDKTRELLIGLDVEEIIVDFKLADIGYIMKSIVERLSFANSFIAHSFIGVKGSLDELKRYLDANSKNLYLVAVMSHEGWSTLFADYIKNVIREISPKGIVVGGTKLDHITQYRRDFEKMTIVSPGMGSQGGSYGDAVCAGADYEIIGRSIYNAGNPLTALRTINKIIEDKVMKCKGAIFRKK
The following text describes a protein:
Function:
Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, A band. Note=Localizes between and around dense bodies. Colocalizes with myosin heavy chain unc-54 at the outer edge of A-bands.
Sequence:
MMFEYEEDEDPMEQQKHEEFKHHSTDHSGSPQENPFRFSYDTGKRAASMFVTPSSEDLIAYGTKHLLDSPTAVQRSLVLNATTSLNIDCDLSSDDDLSPTTQRKICFCASQNPAETQEQGLRPAKSTLAISFPCHQHQITEDYTISAEIIGIGESGKVMACYQKVTGEKFALKVLRDSQKARREVELHWLTNAHENVVSILDIYENTFDNVKCLLMVVEFLEGGDLLSQFESQGSIPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYKLGDYGFAKRPERNVLMESPCCTPFYAPPEVLGRERYDKSCDMWSLGVAMYILLCGYPPFYSMKGVALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELMATPLVTGEPIVPGKHITTAIAIPGADESECGGGVFDDGFIVEEEETPDTVAEILPVPKSVRFLRDGVKAPRLHSIQEEVGRAMEIMRMGTDQVYIKNPTASCNNLFERRRAVHLSIPRVYC
The following text describes a protein:
Function:
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Subcellular Localization:
Nucleus.
Sequence:
MDPGKDKEGVPQPSGPPARKKFVIPLDEDEIPPGVAKPLFRSAQSLPTVDTLAQAAPQTYAEYAISQPLEGAGATCPTGSEPLAGETPNQALKPGAKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDFVSRVTECLTTVKSVNKTDSQTLLTTFGSLEQLIAASREDLALCPGLGPQKARRLFDVLHEPFLKVP
The following text describes a protein:
Function:
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence:
MSDDEEYSSEEEVVEETREEQPAAKSEGDDPEFIKRQDQKRSDLDEQLKEYINEWRKQRAKEEDELKKLKDKQAKRKVSRAEEEQRMAQRKKEEEERRVREVEEKKQREIDEKRKRLEEAEKKRQAMLQAMKDKDKKGPNFTITKKDSSFGMSNAQMERNKTKEQLEEEKKISLSFRIKPLEVDGLSADSLRARATELWETIVKLETEKYDLEERQKRQDYDLKELKERQKQQLRHKALKKGLDPEALTGKYPPKIQVASKYERRVDTRSYDDKKKLFEGGYSAYYQEKINKKWAQRQELFMARTKTKLPKWFGERPGKKSGDPETPEGEDEVKPDDEEVEEVEEVVEEVVEEEEEEEEEEEEEEEEEEEEEEEEEEEEE
The following text describes a protein:
Function:
Negative regulator of programmed cell death and hypersensitive response (HR). Positive regulator of callus differentiation.
Miscellaneous:
MISCELLANEOUS: Plants silencing LSD1 display a lesion-mimic phenotype, increased pathogen induction of PR1, enhanced resistance to virulent rice blast fungus and accelerated and intensified hypersensitive response to avirulent pathogens. Plants overexpressing LSD1 show increased content of chlorophyll b and enhanced resistance to virulent rice blast fungus. Callus overexpressing LSD1 shows accelerated differentiation and plant regeneration.
Subcellular Localization:
Nucleus.
Sequence:
MHLSAGFLSCRERKGDFSCLTAARICEASTSDAVVQAAGTAMPVPLAPYPTPPVPFTPPNGAQSQLVCSGCRNLLMYPAGATSVCCAVCSTVTAVPAPGTEMAQLVCGGCHTLLMYIRGATSVQCSCCHTVNLAMEANQVAHVNCGNCRMLLMYQYGARSVKCAVCNFVTSVGASPGTDQKPSS
The following text describes a protein:
Function:
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MPIQTLDKGDDHVKFFCFQVLEHQVKYKYSELSTAQQQLIRGTLLSWLQAQMLNPQPEKTFIRNKAAQVFALLFVTEYLTKWPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVHTSEEARRNTLIKDTMREQCIPNLVESWYQILHNYQYTNSEVLCQCLEVVGAYVSWIDLSLIANDRFINMLLGHMSVEVLREEACDCLFEIVNKGMDPVDKMKLVESLCQVLQTAGFFSIDQEEDLDFVARFSKLVNGMGQSLIVSWTKLIKNGAVKNAQEALEAIETKVPLMLQLLVHEDDDISSNIIGFCYDYLHILKQLSVLSDQQKANVEAIMLAVMKKLTYDEEYNFENEGEDEAMFVEYRKQLKLLLDRLAQVSPELVLASVRRVFSATLQNWQTTRFMEVEVAVRLLYMLAEALPVSHGAHFSGDVSKASALQDMMRTLVTSGVSSYQHTSVTLEFFETVVRYEKFFTVEPQHIPCVLMAFLDHRGLWHSSAKVRSRTAYLFSRFVKSLNKQMNPYIEDILNRIQDLLALSPPENGYQSLLSSDDQLFIYETAGALIVNSEYPAEHKQALMKDLLTPLMERFKVLLEKLMMAQDEERQVSLADSLNHAVGFASRTSKAFSNKQTVKQCGCSQVYLDCLQTFLPALSCPLQKDVLRSGVRTFLHRMIICLEEEVLPFIPSASEHMLKDCEAKDLQEFIPLINQITAKFKMQVSPFLQQMFMPLLHAIFEVLLRPAEDNDQSAALEKQMLRRSYFAFLQTVTGSGMSEVIANQGAENVERVLVTVIQGAVEYPDPTAQKTCFIILSKLVELWGGKDGPAGFADFVYKHIVPACFLAPLKQTFDLADAQTVLALSECAVTLKTIHLKRGPECVQYLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYLKVFFQRAKP
The following text describes a protein:
Function:
May have porin activity and function in peptidoglycan binding.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKIRNLLVAILAMSGTVVFAQEQRQIKEEGKTVFKPHWFIQAQVGAAHTVGEAKFTDLMSPAAAINIGYKFAPAFGARIGGSGWQAKGGWVTPEQTYQYKYLQGNIDIMADLSTLFCGFNPKRVFNGYLFGGVGLNRGFDNDEANALDTRTYELEYLWQEGKFLVAGRFGLGCDLRLNDRLAINIEANANALSDKFNSKKAGNCDWQLNALVGLTIKLGKSYTKTAPVYYEPEPAVVEQPKPEPVVAKEPEPKPVVVVEPMKQNIFFALNSALLQNDQLAKIDAMIKYMEKNPTSKVAVTGYADKETGNPKINMTLSEKRAKNVVEALKAKGIAADRIITSYKGDTVQPYQKPEENRVCICIAE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MNNHSVYNKFNLTHSVFNNNTNLNNSIYVSGDKKNKSRTSLNNLSFYKPNASVYVKKVDKSDKKDNVKILIRYLGWKNYSGCITPNLFKNPSMTDLINIWNFIFKHVDPLIEVNKDNYGEVVLSFYKDIGYPYTISKSTLVAPTTGLQYNTHLSALAWLCQLLIFEVECFNDINEEKDLSLSYDFNELNEIKMDDFILHSYQSYINKEEKNLNDMLRTNLEKEIDRLDNDINNKIEDINEKKKKVEEIKNHMKENEELIKRNKVLCEENKKIKQLYTNSLDETEKLEKDIEICKISNQDEKNKTENILDEIKKVKDILQKQTLNKAQFVQMNENIDKNKEKIEHIKNEIQALNNEYPNLSEKLNNRNSDLKKIARNINEKFIEIVENINLYKNISTSQWNEIHPININIDSTTVDNMLNVNWKDFKSNVKQFIDKDEQELKNSLNLIEENEKQIKVTEKDIQDLKQEIMDKENLVKQMNEDTNNFLNESTKTFNQIVAENEKMLEEAEEKLSETNEMFSEVRTSREQKENELEKIKEENEKKFKEKLSVLQKACAMLIELKRYSKSYISIVVEEKKKELDLYKDLQKSVVD
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MVELESMSSSSEWFLNNNSNIHNNTHNHNHNNNNNNNNINSNNHGHSANSSAHNHNNNNNNNTNNNSNNSNNNNNNNNNNNNTQNTNNGTFLTPLPVLTNSSTGLGKSIDWLYTNTSNTDSHNINSSSNKVTKLSNGFSLLNQDGTQSPSCFLNLSSTGNHEDPVQVPMNNNPQDLLFQFNISPQLQSQNNNSSNNNNNNNNNGSNTPLNGSNGSNNNYSSPISPVPQYQHSAGSSPIQEYPYYSPSSSPHSNESTSPITVIKDSGSIINPINNNNNNNNNNNNNNNNNNNNNNNNNNKNNLNNNTFQFSSLKSTTGIAPPLQTDYHLLYNFVQQNFSGKPEDSLLNQTLNNNNNNNNNNNNNNNNTTIQTSPQPLVLPQIQNPFLPYNISTPISVPNNILSSAQSSTNSSPNNNNNNNNNNNNIFSTVNNNNNLVNNNSNNMELDVDKPFSQEKFYLHLKSIVPSFNENFEASSESAQSESSQESDYDALNERNSGVKKRGRDEDQIDTSGQVVLSREHVLKLSSKEIEEYVSRLKMHHILTQAEEKELKKQRRLVKNREYASQSRSRRKIYVENIETKLQKTNQDCASIKSQLNSVKEENKALKKQLYSLTNTLKSNPSLAEAFGKIFSPIGNNKTSSATLFVFFFLFTFTFLFQSSTVTFNSDRVSSIQRNLLSLEETQATEWNIKRAILEETKQYVDSLLTSLYTSKLQSLSETPLDTSNYIINNNNNESTSETTTNNKVVSTSSDDISNVLSNLSVSDKEVPQKCKDSSDLKCDSPPLSPLN
The following text describes a protein:
Function:
May play a role in cellular stress response.
Subcellular Localization:
Cytoplasm.
Sequence:
MDPAKLKHIILNARHPYVVRNADPDWACFRQSFAEWCEAFDLAHPDCVPFEGCPVKGGNHPQWEWERTKVKMKMRDICTPTDTRWNSFSYRNIALLPEPCRRGINFACFGFPEVEQDVTFWIGSAQAHTPCHYDTYGCNVVVQVFGRKSWILLPPDAKLTPVRVPFEESSVYCEENFYSPASYGPFTAVEDKVYHVMLEPGMALIVPPKWWHYVETLEPALNFNTWLGLETDVDSLISECITKLLLQDLCNDVPEKVTSRLINPNEDLPTTEESVSESYQILNYLLNQRRNNKRQSSNLRRYPCEYLPVEAFGQLVDECKPFIKPVELLDRCDFNNLINRNRARNDPSYKDKISDELTVDELERIARLRKMVNVCCKPDVVKLIERVLLDETS
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MQTKKKLNGRNPRELASPKVSRQQRKMSEKVQTEAKQVKELITSSVRKQKSGSNFSKKIENHVVSTDLDIRFGLVADATSAASDAHDVVHDYNTITINKDYDGESDSCRSDTIFSPTFHISRSVGGEISNCADFLKFFQQADQPLQEPGKENIEVDLLTSHFVLDEATDLGDQHMSSEVSAVHLSIKDSKLECIDEFNQVQLPADVNMEEEETEEFDDFDPYFFIKNLPDLSSVVPTFRPVLLPKQTRSCPSTTLVLDLDETLVHSTLEPCDDADFTFSVNFNLKDHTVYVRCRPHLRDFMDRVSSLFEIIIFTASQSIYAEQLLNVLDPKRKVFRHRVYRESCIFVDGNYLKDLSVLGRDLAHVIIIDNSPQAFGFQVDNGIPIESWFDDRYDKELLSLLPFLESLVGVEDVRPIISSKFNLRERIAAAVCPFNSIREDKAVPV
The following text describes a protein:
Function:
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.
Subcellular Localization:
Cytoplasm.
Sequence:
FNISIQHRTGGSSQASDRGSTMSVEVSEAASVEEQKEMEDTVTSPEKVEAAKLKARYPHLGQMPVGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNEQLPTAALDKMEVTGDHIPTPEDLPQQKPSIVASKLAG
The following text describes a protein:
Function:
May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.
Sequence:
MDHEAAQLEKQHVHNVYESTAPYFSDLQSKAWPRVRQFLQEQKPGSLIADIGCGTGKYLKVNSQVHTVGCDYCGPLVEIARNRGCEAMVCDNLNLPFRDEGFDAIISIGVIHHFSTKQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRRFEKQDVLVPWNRALCSQLFSESSQSGRKRQCGYPERGHPYHPPCSECSCSVCFKEQCGSKRSHSVDYEPAMARTCFANISKEGEEEYGFYSTLGKSFRSWFFSRSLDESTLRKQIERVRPLKNTEVWANSTVTVQPSRHSSLDFDHQEPFSTKEQSLDEEVFVESSSGKHLEWLRAPGTLKHLNGDHQGEMRRNGGGNFLDSTNTGVNCVDAGNLEDDDPSASKILRRISAVDSTDFNPDDTMSVEDPQTDVLDSTAFMRYYHVFREGELCSLLKENVSELRILSSGNDHGNWCIIAEKKGSCD
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MAVVQKSGEKKRGRSAINEVVTREHTTSIHKRIHGVGSKKRAPRALKEIRKFAMTEMGTPDVRNDTRLNKAVWAKGIRNVPRRICAPLSRKRNEDEDSPNKLYPLVTCVPVTTFKNLQTVNEDEN
The following text describes a protein:
Function:
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly pdi1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on pdi1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MIGITKLISIWNAIWNFLLLPEIIISQTDTSSTGIYQMQSKVRSLVPVLTERSDYFSYYRVNLYRSSCPLWENDNAMCSNQGCAVKSLNEIEIPKVWKKLSDFEPHSKKNDTKCNWKYNPDLDYCYLDNSTSPDEYVYVSLVQNPERFTGYAGDHSAAIWRSIYEQNCFVVDDDDNPSEQPKSNALFRPNQIPLNLFTENHDDTSLSPSVACLEKRMFNRIISGFHASISTHVCQNYYDVEEQRWTQNLDWWRAKVGSFPDRIENIFFNYALLHQALVQIATQMKNITSDSSFTFCPTDKDVDWRTHTAFEQLVYHAYQDRHVINREQFFADEEAKRFKDSFRKHFRDISRIMDCVGCDKCRLWGKVQITGYGTALKLLLEPETQLSDLRPEEVVALVNTFDRISHSVEATFWFSLKAKTNDTLDAIKALIYKTYRSPSKEILAFFIDQTWYLFYALFFICNVPRVI
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSMRNAVQRRQHRERGQLQGREKWGILEKHKDYSLRAKDYNMKKQKIKRLEEKARDRNPDEFAFGMMSSHSSTKGKHGTGMRESATAQGLSHEAIKLLKTQDAGYLRTVGERVRRQIEKVKEDLRIQESMGEALGVQEDTRQEDDGDDFDDFDFGAAEKKARKLLFADDREDQKVLKRVLEQREQEGETEEEEESFGERAQQQQKRKTRKELEAEKQALVEARRARKLKKRALEVRQNKLKALQKQYADITSAERALDLQRAKMSNSVGGVNKNGLKFKIKERKR
The following text describes a protein:
Function:
Required for assembling actin at ring canals in developing egg chambers. Probably interacts with other developmental proteins involved in nurse cell/oocyte transport through the ring canals. Important for normal neuromotor function.
Miscellaneous:
MISCELLANEOUS: 'Hu-li tai shao' means 'too little nursing' in Chinese.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTEVEQPPQNGIDPTAGEDDDNSKARPADIEQDMREMERRKRVEAIMGSKLFREELERIVDSARDGGAGASGILQQLSDIVGVPVSRVGSVFKSSNCMVPINDIRGVESMGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNKVDMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACVLGEITTHAYTGLFDEEERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQLKLLPVGLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSPPKWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEEELFRQGIWKKGDIRKGGDRSRWLNSPNVYQKVEVLETGTPDPKKITKWVAEGSPTHSTPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADKISAGPQSHILEGVTWDEASRLKDATVSQAGDHVVMMGAASKGIIQRGFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVHGEYTDTDFSESEAVLQAGTKKYPQSEPETEHQVIEIQTQQAPVPRQAEVVLSDALVSQLAQKYAFLYSPGQYMYACMKMAPLMHKVYVIHKVEPVSKHNYPPVNDGNMSIHHNESGAGFMAQESSVISSTPVRNALASVSLPEERNHSILGLSSTPYRTISHFGFNCPLITSPTILLHPEHRSIWQRVAEQREKVVSFIDLTTLSLDNRKLLNVVTSTHPTQCQSQSQSFISEKHIQLEVTPPKRKQRVYSATISSGLDDSLDELDSLMSGLAINMPRSREQDSGLYRSYTFLPSNHALPKDTDANNRDQTDRERPEAEQEESFHCAGDSGIGDSTGRRPRLATTSNDSSIQEAEAYTQGKHVKLTLSSSPTPTATQSPATIEILINVSLRNAECVQTVQTHEQEFRAKLERVIDEEIHYISQQLAFKQRQAELHEQQTTSRAPIATPSFTTMHPPAPASSSSMVHRSNSAPELCHTYSYVAVGDLSTKQDQASPQLPAEGEPLNDILSSLEKELERLLNSVVTAHMLHNKAIIHECRARFSQLADGIVSS
The following text describes a protein:
Function:
Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
Sequence:
MFSKLRSFGVRHHRKFIVFGALVGGGVLLKRYAEKKLIEWQETEMNQLLERSRKQQHFESTERTCNMTITSVLPQIQLAIGRSLDSDSITLLLKQKAPNKKDLWEQLKVIAFSRVISYVYGNAILAILLRAQVNILGAYLYLANQNPSKPDLELSPEAQSQFLSASNYWLSTGIEQFCLMVEKVVSSQVANLSLKQRLTLIELEQIFHDIRVALEDELSRQPNGFLANVMLPPQHSSGEAAPASPTLTKMMSETREVLESLEVSQLLSSCVNIGVVCVLDKFSEIVSALHTDTNQPDSQDFLHPNHISVYVAKLIPALNNFIFQDVWLTQLLAIEPLRVFGANIYESFSTL
The following text describes a protein:
Function:
Synthesizes selenophosphate from selenide and ATP.
Sequence:
MSHKRPQSSAGESNGAVDLKTPRFDPVSLGLPAEFQLTDYTRLKGCSCKLPQPKLLALLQELSATPGQKDVGMDCSIVPLHHTNSKGEALFLVSTTDFFFPSVSDPFLQGQIGAANVLSDLYSMGIPDCDTMLMLLAASTEMDEHERLITTREIMKGFAERARLATTTVTGGQTVMNPWPLIGGVAMAVVSEAEMVRPTGLLCAGDILVLTKPLGCQVAVNLKQWLLRPSPLYEEAIAGHISPEEIEELYNMATDSMRRLNREGARLMRKHGAHGATDVTGFGILGHANNFGAAQAVGDAPRSLCLVLERLPMFKTAVAASKQMNDKYRLLEGYSAETSGGLLVAFPSTTAAAAFCAELTAVDGGCPSWIVGHVEDRATNAVDGVYARLKDGYEIVEV
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MPPTRFQPSHQTPFKSTISTSQQSRIFHSPLQAGATANPVSISISDIDPSEWKYHAEGGKNVLLSFDPVGGIQAGKSPFATLTCTYALRIPKSLPSKSESNQEDEQEAEQFTRHVVQPLLGDATVLPKCMRIPIVTARDRHVIDMLSARIEMQRPAARRTHPARIRSEALSYIYAVEDVAAPVSVSPSAQRAVLCVEIKPKWGFLARIDSIPPSSPNVEIKARYSRYRMHRVAKHAAADHAGQMSIEQFERLYDPVDLYSCDSERKQKAIKALWDDWIDTKGKTNNLRLFWNGAVVDPQDSVTLEAIAQFLGTDNSVQGRLKGALTQHLDKELSKRVLGENDEWSTVSVLSRLAHLQSALDPLDVEGLAHLWLRRTQSHVLGQASSDVDLPPALTRNLAAAQLAAMLDSFLSGTTAEVSLEDAVQAFLVSASFKDCSMLLRFHQTESGVQGETKLVDLDSKPFAKLSSMQQTDSEVCAAFLAWLSQLDRSPAASVAP
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MSARRTSREIAVMALYQLELTQPPLKEVLKFKWYDKKTEPEERDFAVSIVNGVVKNQEQIDTLIKKYSKNWDFSRISIVNKAILRLSIYALLYTWEVPKNVTIDEAVELTKEFESEESARFVNGVLDAILKNEIKSDG
The following text describes a protein:
Function:
Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.
Subcellular Localization:
Secreted.
Sequence:
AGSYLLEELFEGHLEKECWEEICVYEEAREVFEDDETTDEFWRTYMGGSPCASQPCLNNGSCQDSIRGYACTCAPGYEGPNCAFAESECHPLRLDGCQHFCYPGPESYTCSCARGHKLGQDRRSCLPHDRCACGTLGPECCQRPQGSQQNLLPFPWQVKLTNSEGKDFCGGVLIQDNFVLTTATCSLLYANISVKTRSHFRLHVRGVHVHTRFEADTGHNDVALLDLARPVRCPDAGRPVCTADADFADSVLLPQPGVLGGWTLRGREMVPLRLRVTHVEPAECGRALNATVTTRTSCERGAAAGAARWVAGGAVVREHRGAWFLTGLLGAAPPEGPGPLLLIKVPRYALWLRQVTQQPSRASPRGDRGQGRDGEPVPGDRGGRWAPTALPPGPLV
The following text describes a protein:
Function:
Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.
Subcellular Localization:
Nucleus.
Sequence:
MHARAGGKRLHHHLRIARAASREGSRFPTRFHFRSSAAATASAAMAAAAVAEPKTKYDRQLRIWGDQGQAALEKASICLLNCGPTGTEALKNLVLGGIGSVTVVDGSKVEQSDLGNNFLLDEGCLGQSRAKSICSFLQELNDAVKAKYVEESPATMIDTNPSFFSQFTVVLATQLPESSLLKLDSICRSANIVLVAARSYGLTGVVRVSIKEHCVIESKPDHSLDDLRLHNPWPELKQFAKSIDICDKDPVVHKHTPYIVILARLAEKWADAHDGQLPSTRQEKREFKDLIRAHMLNVDEDNYKEAVESSYKVSVTPGISDEIRQIIDDSSSEVNFSSSDFWVLVASLKEFIANEGNGELPLEGTIPDMTSLTEYYVSLQKIYQAKAESDCLAIEHRVKSILKRIGRDPDSISRACIKTFCKNTRKLKVCRYRSMEEEFSSPVLSEVKKYFADEDSCFAMNFYVLLRAVDRLAANYSRLPGIFDSEIGEDVPRLKEAAVSVLSDMGLKGSSLSEDLIAEVCRFAGAEIHPVAAFIGGVASQEVIKLVTKQFVPLNGTFIFNGIDLKSQVLAL