lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. Promotes myoblast fusion through ELMO/DOCK1.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKAVRNLLIYIFSTYLLVMFGFNSAHDFWCSALVKGVIYGSYSISEMFPKNFTNCTWTLENPDPTKYSIYLKFSKMDLSCSNFSLLAYQFDHFSYEKIQDLLRNNNSIMQLCDTKNTFVFVHYDKNFIQLRRIYPVDFVGLHKREEDDSRSFLEFLVLNKVSPSQFGCHVLCTWLENCLKLENGKTELCGIMYTKCTCPQHLGEWGIDDQSLVSLNNVILPLNEQTEGCLTQELQTTQLCNLSKEAKRPPKEEFGMMGDHTIKSQRPRSVHEKKIPQEQADAAKFMAQTGESGVEEWSQWSTCSVTCGQGSQVRTRTCVPPYGTHCSSPLRETRVCNNTALCPVHGVWDEWTPWSLCSFTCGRGQRTRTRSCSPPQYGGRHCDGLEMQHKPCNIALCPVDGLWQEWSAWSQCSVTCSNGTQKRQRECSPASHGGSDCKGPYSETRECHNQECTANGQWNPWAHWSGCSRSCDGGWEKRTRSCQGASITGHQCEGSGEEVRRCSEQRCPTPYEICPEDYLMSMVWKRTPAGDLAFNRCPLNATGTTSRRCSLNLHGVAFWEQPSFARCISAEYRHVQLSIKEHLAKGHRMLAAEGMSQVTKTLLDLTQRKHFYAGDLLISVEILRNVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEKWEDAQQIYPGSVELMQVIEDFIHIVGMGMMDFQNSYLTTGNVVASIQKLPASSVLTDISFPMRGRKGMVDWARNSEDKVVIPKSIFTPIPSDLDESTVYVLGAVFYKTLGILLPTLRNFTVVNSKIIVVTIHPEPKSTDSLVDIELAHLNNGTLKPYCVLWDDAKSNDSFGTWSTQGCKTVFTDASHTRCLCDRLSTFAILAQRPREIIMESSGTPSVTLIIGCGLSCLALITLAVVYAALWRYIKSERSIILINFCLSIISSNILILVGQTQIHNKGICTMTTAFLHFFFLASFCWVLTEAWQSYMAVTGKIRTRVIRKRFLCLGWGLPALVVAISMGFTKAKGYGTPHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMVHCILRKEVQDAFRCRLRNCQDPINVDSTSSFPNGHAQIMTDFEKDVDIACRSVLHKDIGPCRAATITGTLSRISLNDEEDENIVKPEGMSYSTLPGNIISKVIIQQPSGLHIPMSMGDMTDQCLKKENSDLRRTVYLCTDDSLRAGDTDMGHSQDRMMESDYIVMPRCAGNMQMKDENKMNIAMDTLPHERLLHYQVSPEFSMNPAVMEQFGINLDQHLVSQEHMQSLSFEPRTAVKNFIASELDDSAGLSRSETGSTVSMSSLERRKSRYSDLDFEKVMHTRKRHMELFQELNQKFQTLDRFRDIPNTGSLHRHIPPHFTEIKHHSHQSLPQWSLQSKDNPPVNKNPWDSFKNTEYQHYTTINVLDSEANNTLELRPSEWEKCLNLPLDVQEGDFQTEV
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm.
Sequence:
MCSFLRVPSPKGLEPSKGLGAPLQPGTAYPSEMSALGPGMTVSGRKSPLSMEVGLAPEGKDDLEERRVFMGTTSPTELGLRVGLRKDFPCSKTYEERMASPEIRSPSSKGLELRLKRQNISRTVMDGSNLGVHRVSASQETKPPLSALPGRVGLEKERFLAGYCPGRVTQPPLGQGCESPQASGGRRCPVTGDPEGFGASVSKLPALGMECRGELGGESACVVMKPRAETEPPVEVDMGLTRLEEPAEMESPEPQMGLVMEPPAWQLAQQPEEQREAENTEPGVEPPDRIRPIYSGKFFDRMPCWPSAGKVLPIGYRAATCLTERFPRLMTPPEAKKFFNFRYPPAGAERVFYGRANDPQIAPSLTHGIRSKISIPAKVLINPQPITTFQQKMKDKKESVYFSNQRAPLGKSHDQTPGLPKGLDILNTTFGTAIVRETSARDMVNPPKPYKEVFEEAQAGHDLYVVSHNDYFVGEAKNRKYDPSSFHRFNLYGIPTPHFNDGRNMAKTLHWLHELQMKRGAKIVSKRVDDFKEKFQHRLGRVLDPIAETMNVPPDYTFGAFLRPEDYGVGDLIHRRLPGEYLRGKDRQRGLVAAVRHHLKKVNYQNFDTLLAAFRHYDKKGDGVIDRAELQEACDQACLHLDEKLLDQLFEYCDVDKDGLINYLEFANFLTWKDKTPLKEYEERVLIKGRKADCANPAEANVEESEPALLLKPEDIVLKEPGSSEKTLRTLLRPSDKVSNHYKTTSSEISAVVGAVPSTCYPTYGVPTIRSDIPAPLIRRVSDRTSYGEEGNAYSLLHPTIFAQKGVFERDFFKTRSKQEISEILCNIGVKLSEDEFENVWNLASKKHHRGEVCVENIRSVLDELQHADGAKCKAAT
The following text describes a protein:
Function:
GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MWRGLWTLAAQAARGPRRLCTRRSSGAPAPGPGATIFALSSGQGRCGIAVIRTSGPASGHALRILTAPRDLPLARHASLRLLSDPRSGEPLDRALVLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFANGKLNLTEVEGLADLIHAETEAQRRQALRQLDGELGHLCRGWAETLTKALAHVEAYIDFGEDDNLEEGVLEQADIEVRALEVALGAHLRDARRGQRLRSGAHVVVTGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLREGVGPVEQEGVRRARERLEQADLILAMLDASDLASPSSCNFLATVVASVGAQSPSDSSQRLLLVLNKSDLLSPEGPGPGPDLPPHLLLSCLTGEGLDGLLEALRKELAAVCGDPSTDPPLLTRARHQHHLQGCLDALGHYKQSKDLALAAEALRVARGHLTRLTGGGGTEEILDIIFRDFCVGK
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MEDECIEIGSDEAGKGEREGPIVVAAVALDGEGRKFLRARGLLESKSVPKKRIEELAGLIREVSISSHVKRVSPEELRELWNRGNLNDLLSIWHFEVVKEVLKDTEACRIIVDSFDRRRLEEAFSQIKGIEVIIESGADLKYPSVAAASILAKFEYQKSDKTGIKWT
The following text describes a protein:
Function:
Involved in the biosynthesis of 12- and 14-membered ring macrolactone antibiotics such as methymycin, neomethymycin, narbomycin and pikromycin. Responsible for removing mis-formed acyl moieties (aberrant decarboxylation) that are bound to the PKS and could block it. Catalyzes the cleavage of methylmalonyl-[acp]. It exhibits some acyl-group specificity, and catalyzes the cleavage of propionyl and butyryl derivatives faster than acetyl malonyl or methylmalonyl derivatives.
Sequence:
MTDRPLNVDSGLWIRRFHPAPNSAVRLVCLPHAGGSASYFFRFSEELHPSVEALSVQYPGRQDRRAEPCLESVEELAEHVVAATEPWWQEGRLAFFGHSLGASVAFETARILEQRHGVRPEGLYVSGRRAPSLAPDRLVHQLDDRAFLAEIRRLSGTDERFLQDDELLRLVLPALRSDYKAAETYLHRPSAKLTCPVMALAGDRDPKAPLNEVAEWRRHTSGPFCLRAYSGGHFYLNDQWHEICNDISDHLLVTRGAPDARVVQPPTSLIEGAAKRWQNPR
The following text describes a protein:
Function:
Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAAQKKQGERVLPARSTRKRRQLPDMLYYDERTDSYVTPQERSLSEANAQTRPAPNTINQAVDAKQSAREARVQELMKSKLYHLRKQQKQARHKRDQWAIDYLEWKKNEDEDVWNSDAEATGPAEHTSSFLDALRFSQQFMKAE
The following text describes a protein:
Function:
Peptide hormone required for contiguous Casparian strip diffusion barrier formation in roots via the regulation of CASPs protein expression and distribution in a GSO1-GSO2 signaling pathway. The Casparian strip is required for ion homeostasis (e.g. iron and potassium ions).
Sequence:
MGMSPLTVKKLGFIFMIVSASALSVSFAGRPSIFVHKKINLREEMVERSMHEHERLLRMNTKDYGNNSPSPRLERPPFKLIPN
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MTSLIAQKNADIITLKVATLKGQEDKNGSNEDLKAGNNMLRAKFKHLEAKVKDLTQQLLNNHAVENERITLLLHQFSNSPSGSSTMMLVQPSPYPALTLLSPVVSVSQSFFSLTLGDHQGDVLANNEIGIVEFFEAKNILVTGATGFLAKVLIEKMLRTTPKINKIYILIRAKDKEAAFDRVTSEIIESKVFKCLKEMLGESYESFIRSKLVPIVGNIHEPNLGMDSIIAHQVAQEIDLIVDSAANITFDLRYDLALEANVNGPYQLMLFAKKCKKLKLLVHYSTAYVNGEREGLIYEKPFTMGESITKERVTSHSPSTKFPSLNVANELDFVSKLKNAIENNDTFDKIMKDLGPERAKLYGWQDTYSFTKVMGEMIIDNMREDIPIVIIRPSIITSSYKEPFPGWIQGFRFHNYWEYPCMFGDPSSLVDVVPVDVVVNTTMAAIAKHGYLQIPELNVYHATSSYMNPFLELQLFNYCYEYFNSSPFVNSKGDQMKIKKMIYFDNMSDFSNYISKKLLKEEEVQDLKAQMRIKRKVKYLENFSKLYEPYTFYKGWFHNGNMRKLMENMSEEERENFDIDVSKINWRDYFVGVHILGVKENALNGKSTIH
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N-ethylmaleimide.
Miscellaneous:
MISCELLANEOUS: The enzyme active site contains a catalytic triad that establishes a charge relay system. This catalytic triad is essential for the dephosphorylation of LPA, PA, and sphingosine-1-phosphate, but is not essential in its entirety for the dephosphorylation of PGP, the nucleophilic histidine alone is sufficient to hydrolyze PGP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell outer membrane; Multi-pass membrane protein.
Sequence:
MRSIARRTAVGAALLLVMPVAVWISGWRWQPGEQSWLLKAAFWVTETVTQPWGVITHLILFGWFLWCLRFRIKAAFVLFAILAAAILVGQGVKSWIKDKVQEPRPFVIWLEKTHHIPVDEFYTLKRAERGNLVKEQLAEEKNIPQYLRSHWQKETGFAFPSGHTMFAASWALLAVGLLWPRRRTLTIAILLVWATGVMGSRLLLGMHWPRDLVVATLISWALVAVATWLAQRICGPLTPPAEENREIAQREQES
The following text describes a protein:
Function:
DNA helicase that stimulates viral DNA replication and recombination. Plays a role in T4 DNA replication initiation by selecting and activating DNA origins. Acts by dissociating and reassociating with the DNA molecule being unwound. Unwinds DNA as a monomer in a 5'-3' direction at a rate of 250 bp/s and can efficiently displace proteins from the DNA.
Sequence:
MTFDDLTEGQKNAFNIVMKAIKEKKHHVTINGPAGTGKTTLTKFIIEALISTGGTGIILAAPTHAAKKILSKLSGKEASTIHSILKINPVTYEENVLFEQKEVPDLAKCRVLICDEVSMYDRKLFKILLSTIPPWCTIIGIGDNKQIRPVEPGENTAYISPFFTHKDFYQCELTEVKRSNAPIIDVATDVRNGKWNYDKVVDGHGVRGFTGDTALRDFMVNYFSIVKSLDDLFENRVMAFTNKSVDKLNSIIRKKIFETDKDFIVGEIIVMQEPLFKTYKIDGKPVSEIIFNNGQLVRIIEAEYTSTFVKARGVPGEYLIRHWDLTVETYGDDEYYREKIKIISSDEELYKFNLFLAKTAETYKNWNKGGKAPWSDFWDAKSQFSKVKALPASTFHKAQGMSVDRAFIYTPCIHYADVELAQQLLYVGVTRGRYDVFYV
The following text describes a protein:
Function:
Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. Encoded in an operon consisting of genes ftsY, ftsE and ftsX.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNRRDAINQIRQFGGRLDRLRKSRGGTGGGRNAPGRQKPTPKPNSRKTNVFNEQVRYAWHGALQDLKSKPLATFLTVMVIAISLTLPSVCYMVYKNVNQAATQYYPSPQITVYLQKTLDDDAAARVVGQLQAEQGVEKVNYLSREDALGEFRNWSGFGGALDMLEENPLPAVAVVIPKLDFQSTASLNTLRDRISQINGIDEVRMDDSWFARLAALTGLVGRVSAMIGVLMVAAVFLVIGNSVRLSIFARRDTINVQKLIGATDGFILRPFLYGGALLGFSGAFLSLILSEILVMRLSSAVTEVAQVFGTKFDLNGLSFDECLLLLLVCSMIGWIAAWLATVQHLRHFTPD
The following text describes a protein:
Function:
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.
Subcellular Localization:
Nucleus.
Sequence:
MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL
The following text describes a protein:
Function:
Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with brd4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. Demethylates other arginine methylated-proteins such as esr1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm.
Domain:
The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
Sequence:
MNHKSKKRIKEAKRSARPELKDSSDWTKHEYCKSFDLSHRSVKDNVERADVQRLSPEEFIQRFEKPYKPVVLLNVEDSWPAREKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYVEYLESTHDDSPLYIFDSSFGEHAKRRKLLEDYQVPLFFRDDLFQFAGEKRRPPYRWFVMGPARSGTGIHIDPLGTSAWNALVQGHKRWCLFPTHTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQQSTWPDEFRPLEILQRPGETVFVPGGWWHVVLNLDTTIAVTQNFASTTNFPIVWHKTVRGRPKLSRKWYRILKQERPDIAAIADKVDLQESTGIASDSSSDSSSSSSSSSSDSDSEADSGSEGDAMTHRRKKRRTGGMMGNGDITSQDDCASKERSSSR
The following text describes a protein:
Function:
RNA chaperone that binds to tRNA precursors and promotes their folding and maturation. Also able to bind misfolded tRNAs. Acts as a regulator of tRNA methylation: binding to nascent pre-tRNAs inhibits the activity of tRNA (guanine(26)-N(2))-dimethyltransferase trm1.
Subcellular Localization:
Nucleus.
Sequence:
MSTEEQKEEIKDISSKQENSSEVPKAEEAGKVVESQKDTTSEEKKEETTEKKEDDGKKDLSFDEAEVLKQVEFYFSDTNLPHDKFLWTTSQKNDGWVPIQTIANFKRMRRFQPLEAIVNALRKSPELLEVDEAGEKVRRMIPLVRVDNKSVMERSVYCKGFGDEKDDTQIALEKFFEENAGPISAVRMRRDDDKKFKGSVFVEFKEPDVANKFLEKVKTAPLKWGEDELTIMSKKEYVDMKAELHKNDPPKFSSKRRRFDAFKEMDRQRPGKYSNRGRKFKKQRSSNASEEKPSAASE
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MAAAAPAPVAGHAHAVLRGRLCDPAFVHSCLRSSPDTNYSKLKYLVASSVSEACNNSVLLLGPRGCGKGAVLDMVLEDLRKEHPDAISVIRLNGMLHSDDNCATKEIARQLCLEHQLSFSKMASSDDNTEFMIDMLRECGLAHKTVIFVLEEFDLFAQGKQRLLYSLLDAMQSLTSQAVVIGMSCRLDADQLLEKRVRSRFSHRKLLFVPSSLDDIQRLMEHLLMLEKDSSLPTNYVTEYNSRLTSIFSNKKFKGVLDSLTDTDATTSNILRFLFRVVSYMDMESGLLSMECFTDALSSMQRQPKMDSLQDLSILELYILVCMNRLEDKEQKSYNFNTIIKEYKSIQDAYKTSDKYATTVCFRAFEHLLDRELITFADTKGRNVALEYRPVKLLISSRELAQSLNLNTTCPAVLQKLLDRERYM
The following text describes a protein:
Function:
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Sequence:
MGAQAQGRPGAASHTGSPHVLQPVASGGTMAQALGEDLVQPCELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVQLDAEVFMALLRRLLPRVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGVKVLFRVGLTLVRLALGTAEQRLACPGLLETLGALRTIPPAQLQEEAFMSQVHSVALSEHDLQRQIRAQLAQLPESASGPPPRPQARLPGAQAIFEAQQLAGARGGTRPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLLTRSRGPPIEGPSRSHRGSTSFLDTRF
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Also a component of the nuclear pore complex where it may contribute to the stable association of the Nup82 subcomplex with the NPC.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus, nuclear pore complex.
Sequence:
MSDENKSTPIVKASDITDKLKEDILTISKDALDKYQLERDIAGTVKKQLDVKYGNTWHVIVGKNFGSYVTHEKGHFVYFYIGPLAFLVFKTA
The following text describes a protein:
Function:
Involved in substrate adhesion, myosin-independent cytokinesis, organization of actin cytoskeleton, and phagocytosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKSQKIGSMILLIGILLAIFNFAYSDDDIERFSINPEKPISFTSDQPGFPTSADFPIGSILANSFYSFGGDVNYFQLNISLMEEFSKDGNTGSQATWNQYTSVPVSPISSAVTANRVYTMSIGSLNRVKKGDITSMESTDFLNDEKYSSLVTTLNGGVSYGDDVFFLSSKSATGEAVLIHINDTATGTFGTSSYDEILLDAAINDPSSITVDSKLGLAFIGDSDGDILVFNMTLKAKIAIYSNSSIANLRSSGVVDEERQLLYICGQAGGMNSYITQVDIFHYSATDITLLHSFTILGSLCPSAGIDVKGGQLFFSTTTSSGSQLIGTDTSGGNTGSLSENIANTQSVAISVDSITKTISVFYPDSVFYGTFKSICPSDCSGHGECNYGTCVCDHNYQGQGCEEELCLTLNNCTGTDNGKCENGFCYCSSEWEGAQCEIRRCKDSCNGYGTCNTANYTCVCDSAHMGETCNELVPPPPCTYYTDSESCLSRTTCGWCEVDGLCKEGDRYGPFEGFCRTWFFDTNVETGVIALACIFIAFVGILYIIDIGTTVPIDIKRAKDYAEENKSGQFPKATHEEASVLWWRDQRSHKAWTFMDQFQLISLVSHIGVVFPSRFISFTEYLDWSNLGIPLPPSINPPQIWSVPTDWTSNTARTILSMAQYENSLGSGDLYLLPNILFWFGLLLGVFLVPLLLAYAIISFMESLIHWKEVVTNRLIHVLVRILTFGYIGVLIAASFAMVTPLHDYRIIIPGAIIFVLYGIGLPIAIWFLLAVPEARLHNPTFKQRFGCLYVHYKPKTDHRFVVFMFIKRFIMAVIIGILSFKPMTNYPLTGTDLAVPIVQVVVIDIALIGYAVLLFIRKPYFDHYQLWLEYLLTAINIVTVSLSLTHIKSPSAAGELIACLIQALALVACIAAYVVAWLQMRSSFIKKVKKYLCCCCKSSKSSGEIDLSKK
The following text describes a protein:
Function:
Toxic when overexpressed in E.coli, leading to long filamentous cells. The toxic effect is neutralized by non-cognate antitoxin HipB. Does not seem to inhibit DNA, RNA or protein synthesis, and unlike paralogous toxin HipA its toxic activity is not counteracted by overexpression of GltX. Binds DNA. Might be a protein kinase (By similarity).
Sequence:
MSELTDLLLQGPRSAPELRQRLAISQATFSRLVAREDRVIRFGKARATRYALLRPYRGIERIPVWRVDDTGKAHKFADIRLCWPQGSCLVTGADGDEQWFDGLPWYLTDLRPQGFLGRAWGRKLAAQLNLTDDIRLWQEEDVLYALTVFNGEYTGGWLVGEGNYQRWITAQHPAEIPLDQKLTHYEQLASDALAGEIVGSSAGGEQPKFTYYAQTPSGNKHVLVKFTVPQQTAVSQRWGDLLIAESIAAQILRDGGIHAIESTVLVTSNRQVFLEAERFDCKGNDGRLPIVSLEAVQSEFISSPGSWPQAMRRLCEQQLVTHQSVAQTEVIWAFGRLIANSDMHAGNLSFYLSEPPFALTPVYDMLPMVYAPNSAGMLRDAAIEVKFDLNVSKSAWLTAIPLAQQFWQTVARDPRISEAFRHIAQEMPEKIRQIEEKVARMGG
The following text describes a protein:
Function:
Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF
The following text describes a protein:
Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. Has an essential role in postembryonic development.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with polytene chromosomes. Associates with the hsp70 promoter when it is inactive, but not when it is activated.
Sequence:
MANVRDSDTSLWLHNKLGTSNDSWINGSICSQLNKEVLRNIKECFPDLQTQVKLKLLLSFLHIPRRLVEEWKAELEEVIEVAGLDSELWVSMLAETMKTFPATSSLNTEISDYEDTRPIFIDMVNDLRKLVTKHSDLGMLPLECQYLNKNALISVVGQQPAPVKHFTLKRKPKSAQLRTELLHKSADAQSSLKKASAPTIPLRSRGMPRKMTDTTPLKGIPSRMPTTGFRSATVPGNAAQRPNLSRTPAGRKDGGIKLIEFTEQPLGYAAAKKRKREQQLEEQQKKQEQKQQQAAAAAAAAATAAASNAGDSSPTDAATASGGETPVTPTSANNSFEIKMEPQQLNQSAGSLEEPQDDEMSGKANMECDIETPEYATATLDFAQATSTSVADGQPGKPAVETKLKTPRTPKSAAKLNNNNNNNNNNSFNHTPKRIKQEIEIKSEEIIVPASIKLEKIETSPSTQRVSIQQQPPSLVQRTPHLLIRSSPQKRQNNGATTSAGTTTTTVGNTTIKMEKLDIKPMIRATGVSPSTSAGTTTTLLTPQQLRQAANPLANLPNNISVKITSAKAKAAAAAAATSSGSQTQSQQPQTLQVQQAPQQSHPPLLINSSTPVILASSPSAQRAKALALPSSSTSATTTTTIPSQAIKTMPLSQLKTATNSGPVIISQTIIQPAKRAQQQAGTSSAAAASQQQQQQQSQQQLLHQQIQQQTQQQAQLPQQPQQQQTQYILATPQQQPQQIQQQQQQQQPILPTLTSFSHSRPMPQTTTLYQATTPSGSGQTPTKILLKTSGSSSVVMTPLRQAQPQQATAVVSSNPPPLVATSAAVVSPGQTTLNIQNVQLPNRPVTIQPASQAAQQQHMQAQLQQQQPHPQHTIVANTTATQQPKLSQVLMQPTAAVGTSGVSALNVSPTSGKNKTIILTQKGVILRNIGGDMYQQIPISNVGNMQGLGGTTLMTTTAGPPSLVKTTPSSGVQLQQQQSGKQILPTLIPTSSLGGQHVIVQQQQPTNVIGNSQQQTIIRPVMTNVGGGLTTLPQGLTLIQRPGQQPQLVQVQAAPGSTQRTIITQSNTAAAASQQQPRQQQQQILVQHKPAPTLQQRLVTSTTSGGQGQQGNPNAGLPRTVQVQVQAQQQQQPQQQQATQQQSQQAPQRRGLSLSNEHVHKAHEMFRKANRVSRPDKALILGFMAGLRENPRPNNENVLVIKLGETEEKVQQDNGHTALCLVESHIRLDYNTGEWKTFQNYRLQDQSAAS
The following text describes a protein:
Function:
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
Subcellular Localization:
Cytoplasm.
Sequence:
MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHLTRYLARRWPGAVIEALDSSPEMVAAAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWVPEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDESWQQFRQELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation; Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEHICLPGSDLMSAVERLDDQYRDERDAAPPEAPSIEAELIEQPAKGRAKLRPLLALAPYVARYRGRAALAFVALTIAALTTLLVPVAVRRMIDFGLTPEGIELINSYFSVMIAVVAVLALASAARYYLVMTIGERIVADLRRDVFAHLLSLSPAFFDSARSGELISRLTADTTQLKSAVGASVSIALRNLMMFFGAVAMMVITSPKLSGFVLLAIPLIVLPLVAFGRWVRRLSRNAQDTLAEASAYAGELVGAIRTVQAYTSEGLAAKRFGGEVEQAYEAARTSTQARAVLTAIIIFIVFASVVAILWIGSHDVLTGAISPGRLGQFVLYAAFAAAGLGQLSEVWGEVSAASGAAERLFEILHVQPDIKAPASPRALPVPARGEVGFDQVSFAYPARLDVKVLDAVSFTVRPGEKVAIVGPSGAGKSTIFHLLLRFYDPRSGAISLDGVPVRSADPRDFRSRIALVPQESNVFAASARENIRFGRPDATDAEVERAAELAHAAEFVRRLPEGFDTPLGERGVTLSGGQRQRIAIARAILRDAPLLLLDEATSALDAESETLVQTALEELMKHRTTLVIAHRLATVLSCDRILVMDQGKIVEQGTHAELVAANGLYARLARLQFEGA
The following text describes a protein:
Function:
Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)) (By similarity). Transport is electrogenic (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWGENIATADLFANATDIHSIVQALTTLANASDVFFLVVMGVLVFMMQWGFAMLEGGQVRKKNVNNVMMKNMVDWLIGCVAWLFIGGILCSKGFDLSAFIDWWKQILGTNWPNNGLDLASWFFGLVFCATAATIVSGGVAERIKFSAYVLISLIITGLLYPLFVYLGPWGASIVPWHDYAGSLVVHGLGGFLALGAIAALGPRIGRFVDGRPVPILGHNIPMAVFGAFALAIGWYGFNVGSSLALGDISGLVCATTTMAMAGGGIGALIASRNDVLFTANGIVAGLVAICSGTDVVSPIGGLIIGLIAGLQVPIVYKLVEKAGLDDVCGVVPVHGTAGVIGAILTGILGLKIFGGAGGVSLIDQIIGAVFCIIYGTGLGYILAKIVGIALGGLRVSEEEEKMGLDMAEHKMPAYPEETVI
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion.
Sequence:
MHYSIIRKLVTAPKLANVPKRKWKSVVGLEVHAQIASASKLFSGSGTSFGAPLNSSVAYFDASIPGTLPVLNRKCVESGIKTSLALGCRVNEVSMFDRKHYFYADLPNGYQITQQRAALANDGKMTFPVITPGKKVYYKTAKLLQLQLEQDSGKSLHDDYLKRSLVDLNRAGLPLMELVFAPDLETGEEAASLVKELILILRRLQTCSCKMEEGALRVDANISIHQEGDPLGVRTEVKNIGSVRSISQAITYEINRQLETVANGGVITNETRNWDAENRRTVAMRDKEVLQDYRFMPEPNLPPLHVNLKPGSMSTEDLLSVAALSEEIPELPEDTRQRLVEQHNLNAETAIILVNEPILLDHFLSITRSLSDLPNKVICNFLINDLLTYCNKLNLDVEDCSIKADDLKDILMSLHAELINLQAARQLVDLLHNNPKAKVSELIELHSLQQICSPDEIENLCQLAIANQAKAVEQYQKGKAKALFAIAGEVAKLSSQKANMKLVVQRLEKLLKPTNK