lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulator of sperm motility and spermatocyte meiosis.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MKAYLKSADGFFVLNKSTTIGKHADSDLVLQSADIDNHHALIEFNEAEGTFVLQDFNSRNGTFVNECHIQNVAVKLIPGDILRFGSAGMTYELVIENPSPVSCPWVRGPAPWPSPQPHLSSSPPDMPFHHGIQPATVQRSWSQGCPRPTMVPPAPHQRPMSASGKMFSFVMDPKSPVINQVWANAMDMSEQCMMDGLSGTIPPTEIFMDHDLSQQDKDEIILLLGREVNRLSDFEMESKYKDALIMNLQAEVADLSQRLSETAAVAAARQSNRCDPKLQGVDEGDDLRQKEIESMKSQINALQKGYSQVLSQTLAERNTEIESLKNEGENLKRDHAITSGMVTSLQKDMSARNEQVQQLQEEVNRLRIENREKEYQLEALSSRCSVMKEELRKEEAQKDRREAQEKELKLCRSQMQDMEKEVRKLREELKKNYMGQNIISKTLREKNKVEEKLQEDSRRKLLQLQEMGNRENLIKINLERAVGQLENFRNQVIKATFGKTKPFRDKPITDQQLIEKIIQVTEDNLSFQQRKWTLQRETHLHPKQEETMHSVEKLRVLLDKCQACMRDSCSSIDLKKEVELLQHLPLSPLVSGLQKTVVNILRVSLSWLEETEQLLGDLDIELSDSDKGFSLCLIYLLEHYKKIMSQSQDLQAQMNASRETQKSLRQEHLAEKEKLAEKLEQEEKLKAKIQQLTEEKAALEESIGQEKSRSEEALEKAQARVRELENHLASQKEALENSVAQEKRKMREMLEAERRKAQDLENQLTQQKEISENNTYEKLKMRDTLEKEKRKIQDLENRLTKQKEEIELKEQKENVLNNKLKDALVMVEDAQQMKTTESQRAETLALKLKETLAELETTKTKMILTDDRLKLQQQSMKALQDERESQKHGFEEEISEYKEQIKQHSQTIVSLEERLCQVTQYYQKIEGEITTLKNNDTGPKEEASQDLTAGPPLDSGDKEIACDHLIDDLLMAQKEILSQQEIIMKLRTDLGEAHSRMSDLRGELSEKQKMELERQVALVRQQSGELSMLKAKVAQTTGLMEKKDRELKVLREALRASQEKPRPHLSTEQKPRTLSQKCDISLQIEPAHPDSFSSFQEEQSFSDLGVKCKGSRHEETIQRQRKALSELRTRVRELEKANSCNHKDHVNESFLELRTLRMEKNVQKILLDAKPDLTTLARVEIRPPQNSPFNSGSTLVMEKSVKTDAGEALELSEKLYTDMIKTLGSLMNIKDMSSHTSLKHLSPKEREKVNHLRQKDLDLVFDKITQLKTRLQRKEELLKGYEQELEQLRHSKVSVQMYQTQVAKLEDDVHKEAEEKALLKEALERTEQQLSQERRFNRVFKQQKDRGEDPEQRNMSYSPFKDNEKQRRLFVEMVKSKMQNSSVQAGAKKATLKTGQERETKKEAYKSTQSLSFVKPGGKN
The following text describes a protein:
Function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Sequence:
MVLSRSRSLVSLLLGVSRPLCFSCTSRVLGSIHRSLTGSADDTMAVDTNGINVAAMRKSYKAGHQAFTEDDLNSKDPMMQFTAWFKEACEATQNSKTEANAMTIATATKDGRPSARMVLLKGYDETGFRFYTNYESRKGRELAENPFAALVFYWDFQSRSIRIEGPVVKLAAEESSEYFHSRPKTSQIGAVVSNQSTPIEDRHILTKKDAELKEQYKDESSVIPRPDYWGGFKVIPDVIEFWQGQSNRLHDRIVFRKPREAENIDGKLVHQGENGWVYERLSP
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAVEDTLLALSSLVAFAMLWAAGANDVANALGTSVGSKALTFQRAIVVGAIFELLGASLVGGGVESTIESDIISVNDFGSPRRFAIGMFAAIAATFLWVTVATIAALPVSTTHAIIGSVIGFAIAEGRGRFLQGQNIGLTAASWIVSPLLGGLIAFGIYLMLKHLVLKPTSRLRRAELSLPYLFALNLATDAVFVVAGGPDLLRPRTDSPEQALGQIYVPIFVGTFVVAGLAGRFWLLGWIRRHRHDNDEELLLPLSAPDGGRTTIASRQQQHTGDATNSYGPCEAYFAPLTVASACTVAFAHGGNDVANALGPLSVVINFWRNHLDSHLSLPFWVNFLGGVAIVAGLTTYGQRVMETVGSGITRLSFSKAFAAQFGASVSILTATVLGLPISTTAVLRRPWARCH
The following text describes a protein:
Function:
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.
Miscellaneous:
MISCELLANEOUS: The name 'dim gamma-tubulin 4' derives from the decreased gamma-tubulin staining of the spindle pole seen following RNAi-mediated knockdown of dgt4 in S2 cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
METPPTPTTTTPPSLTTEGTMDDIQYLLHLEAMRRFQEDSRNVKRQVEEQVRIWLDAKCEYQRDFGRLARLLKCGALQAAVDAHRVSDVNQVDQAAKDIASLRSKLGSDLRPAILDSNDVKQCLEHLNTTHKPRLNLCRQQREFAQNQEALRSLRTAVDGLENGMEMGMIQAMDRLVEDLLPPRETNN
The following text describes a protein:
Function:
Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.
Sequence:
MAGPWDAVLRDEAALRQAAVVAVDAALLEGVLMRTDAEPNASEVVSYAPFTLLPSAVPRALFEQAYAVQRDFNLLVDAISRDKEFLERTLARGSDSTTSLGGCATASLLLQRSTIKVDDFTARLFKIHQQVLEEGLAQSVFLGINRSDYMFDCGAGSLPALKQIEINTIAASFGGLASRTAAVHGRVLRVLGKPEEAARLLPNDPARGLAMGIAKAWELYGSPSAVVMFLVEEAQRNIFDQRCVENELWDRNIRVIRRRFRDVYEQGSLDGSRRLYVGGQEVAVVYYREGYVPSNYNQQNWEARLLLERSRAVKCPDIATQLAGTKKVQQELSCPGTLEKLLPGHAEAVKRIRATFAGLYSLDVGEEGDQIAATAIASPERFVLKPQREGGGNNLYGEELRQVLERIKDSPERTSYILMDKIEPQPAVNYLLRARSPLKASKCISELGIFGVYVRQGTELVLNEAAGHLLRTKAVEHADGGVAAGVAVLDTPYLV
The following text describes a protein:
Function:
Exhibits an obligate exchange activity for serine, threonine and aromatic amino acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDSKMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIYGPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTIGKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEMKNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIGGKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISFQIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFMPILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS
The following text describes a protein:
Function:
May be involved in neurotransmitter secretion. In association with the GTPase activator protein tbc-8 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Co-localizes with tbc-8 at cytoplasmic vesicle membranes in neurons.
Sequence:
MAAQFYERNTSGMNADRFMTRLTDESTVNTMQRHYWTARQFIRTKLGKKEDEHLEASDNELDTCLNLYRSVHGTSFQLLNNVDNYANFLLDETLVQNVLGKYLKEKGKIDKTEAVGRILIAVGRSLLFSSHRLNAARIGVSTFYNKLSVFVERAIGDCSQTIEAVQMCRTEYRGSLLWMKKTSEELDPEVDGSMEKFREAQTTVKSNKERLDRLKTDTLQKVDLLSASRSNLLSYVLTHYQNELYEYYSKTSRAFETLAENINCYNNYDFEILSHLATGTKPERERKSEKEESAKTSQPRGNEEELKNLLFGRESPQFGEEEVQDESRSQCDSPLIEDVDDERRKTGDLLDLESAASIAFPIGPLATLFDTSSFVPPILPPPKPNAVSDDILSLFDGNKANSSGKEASATTMDWQSLIDGFDRENEDNLL
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MIIKRKLKSAMPSLKRCRVSESGGGGDDDEWSGKSRKKRKTKNGSHGHGYYPLHLLGEVAAGIITLSELGFHFAAGVIPSFCSDTGAVVIVDSKPIAPKTELEDNSNAINNDTVRPAKPRPPLVRTSRGRVQVLPSRFNDSILDNWKKEKTKLDVNQDSHFDHEFTPIKDKSTLKIPKPRDQIQTKKHVGDKVSYKCRKSLPKFEEFEDEEYKSFEMTKYSRLNSQHDDDDNDTNIKAPDEFSPGDIVWAKSGKHYPAWPAIVLDPVLHAPQQVLGFRVDGAYCVMFFGYSGNGTQRDYAWIKSGMIYSFVENVDRFQGQTDLNDNEPSVLRSAIEEAFLAEHGFTEMLMVEINAAAGNLDYLDSIPRGVQNLEHQRISQKQEVSNRRHSQSCEGCGSTISLRMLRKMNDTSPNNRLLCNTCAKLTKLKHYCGICKKIWNRADTVRCDGCKVWVHAECDKISGHHFKDLGATDYYCPDCKAKFNFELSDSETYQPKHRCNKKQEEMVLPDKVTVVCTGVEGVYFPSLHLVVCKCGSCGTEKLALSEWERHTGSKVKNWKTSIKVKDSLLPLEQWMLQVAEYHARTVVSVNSLKRPSLKARKQKLLSFLQEKYEPVNAKWTTERCAVCRWIEDWDYNKIIICIRCQIAVHQECYGARNVQDFTSWVCRSCETPDIERECCLCPVKGGALKPTDVDPLWVHVTCAWFRPEVCFASDEKMEPALGILSIPSNSFVKICVVCKQIHGSCTQCSKCSTYYHATCASRAGYRMELHSLEKNGKQITRMVSYCAYHRAPNPDTVLIIQTPGGVISAKSLLLNNNKNGSRLISSRRLQLQPEKASISEISNEAEPFSAARCRVHIRSDNKRTENDRVCFGRSGIHGWGLFARRNIMEGEMVLEYRGEQVRRSVADLREASYRREGKDCYLFKISEEVVVDATDKGNVARLINHSCMPNCYARIMSVGGDESRIVLIARTNVTTGDELTYDYLFDPDESDECKVPCLCNAPNCRKFMN
The following text describes a protein:
Function:
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity). Acts as a component of the DHIC (ddl-1-containing hsf-1 inhibitory complex) which modulates lifespan by sequestering the heat-shock transcription factor hsf-1 to negatively regulate its binding to DNA and its transcriptional activity.
Sequence:
MNASSRTKPAIDLNKVPPIDHHRTAVTFNCLIMKMTEMLNNFGNKMEDILEKAEQSLDTADRKLRLMESKLAGMSLEDKSTTATPSSAPEIDEIHESNPSSSQIVEETVEEKPEEHTTTVLIKDDPAYSKYFKMLKLGVLEAGVIQKMKSEGVDPSILKRGDEPSRPQAQTSRNYESSGESTASFSDSD
The following text describes a protein:
Function:
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Sequence:
MSEKEEYKNNNNNNNNNKQIDKQNKIPIKGYHISAKLTYFKLLEDYYFSKRNDWIKVNALTAPIGEDFQSTIDLCNQYSNENNNNDNDNIDKSKIPLLYTNLSIEHNEKTMAIRGPYFLDHSSIESSIESSIESSSSSSSSLSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSNNKLARIINNNSIIRNAIPNYQILTDKYLLYKHLFNSKSKYQVPTYFINRGKFENKLEINDNDNNDRVIWYLKDPLLNKSQGIKLFKSIENVLEFIEINENKNSRYLLQKEIHPKLLNGIFKFDIRIFLVITFTPNHTLVYIFKEGIVRSTNSPYKKGDITRDSQLTNFCYQLEINPDFQNILPLSQFEKNNNNNNNNENNNNENNNNENNNNNKIFNKLKNATKNIFSSLLNILNNQASGDKISGWSLFGLDFILDENENPFLLEINISPSTFQKSPNDVSSICQNLIKQVPIITF
The following text describes a protein:
Function:
Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAVYRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRLDRMGRDFAPGSVQKYKVRCTAELGELLLLRVHKERYAFFRKDSWYCSRICVTEPDGSVSHFPCYQWIEGYCTVELRPGTARTICQDSLPLLLDHRTRELRARQECYRWKIYAPGFPCMVDVNSFQEMESDKKFALTKTTTCVDQGDSSGNRYLPGFPMKIDIPSLMYMEPNVRYSATKTISLLFNAIPASLGMKLRGLLDRKGSWKKLDDMQNIFWCHKTFTTKYVTEHWCEDHFFGYQYLNGVNPVMLHCISSLPSKLPVTNDMVAPLLGQDTCLQTELERGNIFLADYWILAEAPTHCLNGRQQYVAAPLCLLWLSPQGALVPLAIQLSQTPGPDSPIFLPTDSEWDWLLAKTWVRNSEFLVHENNTHFLCTHLLCEAFAMATLRQLPLCHPIYKLLLPHTRYTLQVNTIARATLLNPEGLVDQVTSIGRQGLIYLMSTGLAHFTYTNFCLPDSLRARGVLAIPNYHYRDDGLKIWAAIESFVSEIVGYYYPSDASVQQDSELQAWTGEIFAQAFLGRESSGFPSRLCTPGEMVKFLTAIIFNCSAQHAAVNSGQHDFGAWMPNAPSSMRQPPPQTKGTTTLKTYLDTLPEVNISCNNLLLFWLVSQEPKDQRPLGTYPDEHFTEEAPRRSIAAFQSRLAQISRDIQERNQGLALPYTYLDPPLIENSVSI
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MARKSLIQREKKRQKLEQKYHLIRRSSKKEISKVPSLSDKWEIHGKLQSPPRNSAPTRLHRRCFLTGRPRANYRDFGLSGHILRAKVHACLLPGATRSSW
The following text describes a protein:
Function:
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDKTQPHPLFKLATELGPLLVFFFVNAKFNLFAATGAFMVAIVAAMIASYVVTRHIPIMAIVTGVIVLVFGTLTLVLHDETFIKVKPTIIYGLFAAILGGGLLFGRSFIAVMFDQMFNLTPQGWRILTLRWALFFAGMAVLNEIVWRTQSTDFWVNFKVFGVTPITMIFAIAQMPLTKRYHLEPVSLEASEADAGDVRKG
The following text describes a protein:
Function:
Minus end-directed microtubule (MT) motor involved in spindle midzone assembly, poleward transport of newly captured kinetochores along the lateral side of MTs, karyogamy (nuclear fusion) during mating, and with an essential function in meiosis I. Functions together with the accessory proteins CIK1 or VIK1. Drives the poleward transport of newly captured kinetochores along the lateral side of MTs, both during S-phase and during M-phase. To contribute to spindle midzone assembly during mitotic metaphase, the nuclear KAR3-CIK1 motor cross-links anti-parallel microtubules to align them on the spindle axis; as the motor travels polewards splayed microtubules are pulled into alignment. During the karyogamy (nuclear fusion) step of mating, KAR3-CIK1 cross-links antiparallel cytoplasmic microtubules emanating from the spindle pole bodies of mating partners; the motor activity of KAR3 creates the force that pulls the nuclei together by sliding cross-linked microtubules past one another. KAR3-CIK1 promotes microtubule shortening predominantly from the microtubule plus-end. Together with cytoplasmic VIK1, may act to stabilize microtubules. Requires accessory protein VIK1 for spindle pole body localization and to allow the CIN8 and KIP1 motors to generate outwardly directed spindle forces. Essential during meiosis I. The ATPase activity is stimulated by microtubule-binding.
Miscellaneous:
MISCELLANEOUS: KAR3 contains two globular domains separated by an alpha-helical coiled coil. The N-terminal portion of KAR3 contains a microtubule association domain distinct from the kinesin-like C-terminal domain; MISCELLANEOUS: Present with 3250 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus. Cytoplasm, cytoskeleton. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic microtubules.
Sequence:
MESLPRTPTKGRSTQHLSTPSPKNDILAMNGHKRRNTTTPPPKHTLLKPQRTDIHRHSLASQSRISMSPNRELLKNYKGTANLIYGNQKSNSGVTSFYKENVNELNRTQAILFEKKATLDLLKDELTETKEKINAVNLKFETLREEKIKIEQQLNLKNNELISIKEEFLSKKQFMNEGHEIHLKQLAASNKKELKQMENEYKTKIEKLKFMKIKQFENERASLLDKIEEVRNKITMNPSTLQEMLNDVEQKHMLEKEEWLTEYQSQWKKDIELNNKHMQEIESIKKEIENTLKPELAEKKKLLTEKRNAYEAIKVKVKEKEEETTRLRDEVALKQKTNLETLEKIKELEEYIKDTELGMKELNEILIKEETVRRTLHNELQELRGNIRVYCRIRPALKNLENSDTSLINVNEFDDNSGVQSMEVTKIQNTAQVHEFKFDKIFDQQDTNVDVFKEVGQLVQSSLDGYNVCIFAYGQTGSGKTFTMLNPGDGIIPSTISHIFNWINKLKTKGWDYKVNCEFIEIYNENIVDLLRSDNNNKEDTSIGLKHEIRHDQETKTTTITNVTSCKLESEEMVEIILKKANKLRSTASTASNEHSSRSHSIFIIHLSGSNAKTGAHSYGTLNLVDLAGSERINVSQVVGDRLRETQNINKSLSCLGDVIHALGQPDSTKRHIPFRNSKLTYLLQYSLTGDSKTLMFVNISPSSSHINETLNSLRFASKVNSTRLVSRK
The following text describes a protein:
Function:
Sodium-independent facilitative hexose transporter. Can transport D-glucose and D-fructose. Can transport D-mannose, D-galactose, D-xylose and D-glucosamine.
Miscellaneous:
MISCELLANEOUS: Experiments with hexose analogs indicate that hydroxyl groups at positions C-3 and C-4 of glucose are important for high affinity interactions with HT1.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTKSSKDICSENEGKKNGKSGFFSTSFKYVLSACIASFIFGYQVSVLNTIKNFIVVEFEWCKGEKDRLNCSNNTIQSSFLLASVFIGAVLGCGFSGYLVQFGRRLSLLIIYNFFFLVSILTSITHHFHTILFARLLSGFGIGLVTVSVPMYISEMTHKDKKGAYGVMHQLFITFGIFVAVMLGLAMGEGPKADSTEPLTSFAKLWWRLMFLFPSVISLIGILALVVFFKEETPYFLFEKGRIEESKNILKKIYETDNVDEPLNAIKEAVEQNESAKKNSLSLLSALKIPSYRYVIILGCLLSGLQQFTGINVLVSNSNELYKEFLDSHLITILSVVMTAVNFLMTFPAIYIVEKLGRKTLLLWGCVGVLVAYLPTAIANEINRNSNFVKILSIVATFVMIISFAVSYGPVLWIYLHEMFPSEIKDSAASLASLVNWVCAIIVVFPSDIIIKKSPSILFIVFSVMSILTFFFIFFFIKETKGGEIGTSPYITMEERQKHMTKSVV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MGVKWLLRWQPPTSLPLTTPMFEEILANAEAIGAQQGGRWQLTSTLYRPIVREAKGGEPAAVRDLFMITGTEHPEKLWLVVRQEKQVLVADASLLAILDKVQLYKQRTAVTFEGRVYEMGDFRLRLGRAVFSINEQLRGITLEVEYLPTQSSAQAVPMLTEFFAVWDESLKSKSLLGKFVVVDPLFEEFGLSDNYSLQHMALHYVYLSTLFLIGTRVS
The following text describes a protein:
Function:
May regulate apoptosis of neural progenitor cells during their differentiation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAPEPAPRRAREREREREDESEDESDILEESPCGRWQKRREQVNQGNMPGLQSTFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTVFEQLVLVDHPNIVKLHKYWLDTSEACARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWHRIFSNALPDDLRSPIRAEREELRNLHFFPPEYGEVADGTAVDIFSFGMCALEMAVLEIQTNGDTRVTEEAIARARHSLSDPNMREFILCCLARDPARRPSAHSLLFHRVLFEVHSLKLLAAHCFIQHQYLMPENVVEEKTKAMDLHAVLAELPRPRRPPLQWRYSEVSFMELDKFLEDVRNGIYPLMNFAATRPLGLPRVLAPPPEEVQKAKTPTPEPFDSETRKVIQMQCNLERSEDKARWHLTLLLVLEDRLHRQLTYDLLPRGARGRPRPSVPHASLLPQDDRMKLAAFLESTFLKYRGTQA
The following text describes a protein:
Function:
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Sequence:
MKASEKKAKEISKKAKEKQKTILESLKNHGAKIYEDLENGQFPKFSIPSRSVSNIVYDKKLRQYILGNSTALRSAKNSAQLRSFTQLMWLAFFANRLTQEKKSSTLRDVYYSSQAFAIEFDDQSESDNIIVDLEAVTSRPREDFHIFPEERSSIFGDLNIEYTIPGYEGKKMNLSNHPDGYSIGPSLTTAELVDTSAEIVIAIEKGGLFTRFVEEQVDKKFKSIIINTGGQAPRSTRTLLKRLHDEMGLPVIILTDGDVYGEHIAMVIKSGSANAAHLRELTVPDAKWVGVWATDIEKYKLPTIPMTESDIKRCYDLQKDPRYESGIWKKELEVFLRLKRKAELEAFAKYGLTNITDKYLPQKLELAKSL
The following text describes a protein:
Function:
Nuclear genome-encoded factor required for normal assembly of chloroplast polysomes.
Subcellular Localization:
Mitochondrion. Plastid, chloroplast.
Sequence:
MTKEKELFRPRVPGRVGMYVCGVTTYDLSHIGHARVYVTFDVLYRFLKHQKYDVCYVRNFTDVDDKIIARANELGEDPLSLSSRYCDEFHSDMAYLQCLPPSVEPRVSNHMNQIIDMIKQILDNDCAYIIDGDVYFSVDKFPAYGRLSGRKLEDNRAGERVAVDSRKQNPADFALWKSAKDGEPYWESPWGPGRPGWHIECSAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQSCAACSKSNIGYWIHNGFVTVNEEKMSKSLKNFFTIREVIELYHPLALRFFLIGTHYRSPINYSMTQLDIASDRLYYIYQTICDCEETFHQHHGNDLKDSLPQDTLQCIQKLHLDFESSMSDDLHTPVALASISEPLRIINDLLHTRKGRKQELRIESLSAMVKEIKNLLGILGLAPSNYSEVLQQLRERALRRVGLTEDELLLKIDERTTARKNKQYDKSDEIRKGLAAIGITLMDSHTGTTWKPTIPHDVHEHASAM
The following text describes a protein:
Function:
Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction. Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases. Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions. Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Domain:
Two conserved structural elements specific among monoglycylases, IS1 and IS2, are involved in glycyl chains initiation. Two conserved structural interfaces likely constitute the binding platforms for tubulin tail and microtubule; Arg-340 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
Sequence:
MAHHTAVNPDRLKHAKALVEKAIKQKKIFAIHGPYPVIRSCLRSRGWVEKKFPKSGKAKQKKEKASDEDMEDDDGDGSSNDDDDGENSDEEENGDPDGTCDLMSRLLRNEDPNFFWTTKRDAVDCRFLKKDQMLNHYAKAGSFTTKVGLCLNLRNLHWFDDADPDSFFPRCYRLGAEDEKQSFKEDFWHTAARSILKRVANRRDICSPAATGGAKASHREPGANNGAQLLAKRGSRKRAESVPVQIILTALEACERYLNSLEHNDIDMETEATPAMTDTQWEEFLHGYYQVIHDGATIEHSEYYVDQCSEVLHKLEAVNPQLDIEGGRNIWIVKPGAKSRGRGIICMDRLEEILKLVDCDPMIVKDGKWVVQKYIERPLLIFGTKFDVRQWFLVTDWNPLTIWFYKECYVRFSSQPFSLENLDTSIHLCNNSIQKHYENSQSRHPLVPTDNMWSSRQLQVHLHKLGAPHAWEAVIVPGMKAAIIHAMQSAQDIVEYRKSSFELYGADFMFGENFHPWLIEINASPTMAASTTVTSRLCAEVQEDTLRIVLDRKLDRNCDIGAFELIYKQCAVDIPQYLGINLLVEGSMVKKPRQLQQPNPNGAFNLSIVQSNKRSVSLLNAKTSGSNPGVGSQDSVKVAVPTRTAPAVMGNDFWTSRTHGTIGRAKTTAAGKENKAAEGGQRNSVMVELVRLPSKRALEQSKEGTNPRQRLFPAPKSCTLEKPIRVRQPIRLKNGGFVDLKFTSLDSGQVQLLRNMKTGMTDPNKMPCLFCKGPSSLTGLHAMCSCSRAGKQAAKPTCLKLSKRIIIGKFHGSSAALSARGTAILTSLLP
The following text describes a protein:
Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MNSNNTTAGNVSLIQENVGLEIQYSVDIILITVLTSFLILLTVLGNTFVIVAFIIDKRLRNQCDFVLLNLAICDFLIGAFTCPIYIPYILTGKWKLGRFLCKLWLTVLYTVSTASTFNVVLISFDRFLSVTKVVLYRSLQNKWSHIFVSIASVWIFAFLLYGPTILFWKNDAIDSSDPLTTCVAGFNDIWYVSFGISCADFALPVISISFFNLSIYCNIKKRDRKKRQKSILENSKGKENDGKLNIISTNNVLFSAQLHTAENRGTKKRLSLSLRHCFPYRKPSSFIQNEATPQHRKISPVSLSRDEKIAKSLSVLIGVFVICWAPYSFLTSIRAACSGYCVDSYWHGITAWLLYMNSAINPILYPLCHKSFRKAFILVAEKIKKFLKI
The following text describes a protein:
Function:
Creatine:sodium symporter which mediates the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MRPLDLGTSPAGPGQPAGGHPESTLCLTPRCVRLFPCILIALVGGIPNFLLGDLGRWPGKNLHGKDFLAPGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFHHEGCASASLANLTCDQLADHRSPVIKFWENKVLRLSGGLEVTLCLLACWVLGVKSMGKIVYFTATFPYVVLVVLLVLGGLLPGALDSIIYSLKPDWSKLGSPQVWIDVGTQIFFSYAVGLGALTALGSYNRFNNNCYHGTSFFAGFVVFSILGFMAAEQGMHISKVAESGPGLALIAYPQAVTLMPVAPLWAALFFFMLLLLGLDSQICVEGFITGLLDLLPASYYFCFQREISVALCCALRFVIDLSMVIDVTVYYSASSNTLLWQAFWECVVEAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLFYNNTNVYPWWGEAMGWAFVLSSMLCMPLHLLGCLLRAKGTMAECWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESKGQVCKAGDSTALGQMGTGGEGLALPWV
The following text describes a protein:
Function:
May play a role in sperm motility, especially in the regulation of flagellar function.
Sequence:
MPAHIEEELPPPSPQPSNPEDGELYSQYKVVRTLGHGTYAKVLLAQHRLTGTPVAVKVLLKNKPCFQPAMKEANIMKKIKHPNIVSLLQVIETKTRGYLIMELVEGQELYEYIKNSGHIEEDEARQIFLQILSAVGYCHGSGIVHRDLKPDNIMIDSKGSIKIIDFGLSTQVKPGQLLHEHCGAYAFGAPELFLWKSYDGTKSDLWALGVILYYMVVGKVPFDSFIIPELQMQILAGVYPAPCGVSNELKDLLSLLMTVNPKYRPTVTEVMKHPWLKGYCKGLTNIHEEPVPVRPDPDIVDAMQYIGFQAKDIRESLTKEKFNEMSAAYYLLEEQALQREVRSTQAPTVSQVKAPFPSMDAGAASCLKIKRSGSAPILGRSVWPSSIGQVPAYGQKVRQRAGRRSTGHGLVFRPNQMTPTQDQHHIRAMSVPCMLSTSSISEESVSEKREENLSNSAPAEDKPIRSRGWRRGIMRWTRRVGNAIRTLCCCIPSRKTPRLGQRRVSPQK
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Subcellular Localization:
Secreted.
Sequence:
YLDHGLGAPAPYVDPLEPKREVCELNPDCDELADQMGFQEAYRRFYGTT