lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Highly selective and weak inward-rectifying potassium channel. Plays a role in both loading and unloading potassium into/from the phloem sap. Seems to control sugar loading into phloem via a voltage-dependent process. Blocked by physiological concentrations of external calcium and by external acidification. May interact with the cytoskeleton or with regulatory proteins. Dephosphorylation by PP2CA not only leads to the inhibition of potassium currents but also to an increase of the voltage-dependence of the channel. Regulated by the CBL4/CIPK6 calcium sensor/protein kinase complex via a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Targeted to the cell membrane when interacting with CIPK6 and CBL4.
Domain:
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids. The pore-forming region H5 is enclosed by the transmembrane segments S5 and S6 in the Shaker-type (1P/6TM) and contains the GYGD signature motif which seems to be involved in potassium selectivity; The KHA domain (rich in hydrophobic and acidic residues) present in the C-terminal part is likely to be important for tetramerization.
Sequence:
MDLKYSASHCNLSSDMKLRRFHQHRGKGREEEYDASSLSLNNLSKLILPPLGVASYNQNHIRSSGWIISPMDSRYRCWEFYMVLLVAYSAWVYPFEVAFLNSSPKRNLCIADNIVDLFFAVDIVLTFFVAYIDERTQLLVREPKQIAVRYLSTWFLMDVASTIPFDAIGYLITGTSTLNITCNLLGLLRFWRLRRVKHLFTRLEKDIRYSYFWIRCFRLLSVTLFLVHCAGCSYYLIADRYPHQGKTWTDAIPNFTETSLSIRYIAAIYWSITTMTTVGYGDLHASNTIEMVFITVYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVNRNRLPPRLKDQILAYMCLRFKAESLNQQHLIDQLPKSIYKSICQHLFLPSVEKVYLFKGVSREILLLLVSKMKAEYIPPREDVIMQNEAPDDVYIIVSGEVEIIDSEMERESVLGTLRCGDIFGEVGALCCRPQSYTFQTKSLSQLLRLKTSFLIETMQIKQQDNATMLKNFLQHHKKLSNLDIGDLKAQQNGENTDVVPPNIASNLIAVVTTGNAALLDELLKAKLSPDITDSKGKTPLHVAASRGYEDCVLVLLKHGCNIHIRDVNGNSALWEAIISKHYEIFRILYHFAAISDPHIAGDLLCEAAKQNNVEVMKALLKQGLNVDTEDHHGVTALQVAMAEDQMDMVNLLATNGADVVCVNTHNEFTPLEKLRVVEEEEEEERGRVSIYRGHPLERRERSCNEAGKLILLPPSLDDLKKIAGEKFGFDGSETMVTNEDGAEIDSIEVIRDNDKLYFVVNKII
The following text describes a protein:
Function:
Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.
Sequence:
MASDSAATVDGSALAGRALAAAGARHMFGVVGIPVTSLASRAAAAGCRFLAFRNEQSAGYAAAAYGFLTGRPGLLLTVSGPGCVHGLAGLSHATANAWPLLMVSGSCDQRDAGRGDFQELDQIAATKPFAKLAVKAAAIADIPRLVFQALAATVAGRPGGCYLDIPSDVLHQTLAESEAASLIAEAVAAAGSADPSPPKHKSLDQGIVEAAELLRRAERPLVVVGKGAAYARAEEAIQKLVDTTGIPFLPTPMGKGVVPDVHPLSSTAARSLAIGQCDVALVVGARLNWLLHFGEPPKWSKDVKFILVDVSEDEIELRKPQVGLVGDAKRVVELLNREIKDQPFCLARSHPWVDAITKKSKDNVLKMEAQLVKDVVPFNFMTPMRIIRDAILAEGSPAPIVVSEGANTMDVGRAVLVQNEPRTRLDAGTWGTMGVGLGYCVAAAVAEPERLVVAVEGDSGFGFSAMEVETLVRYQLPVVVIVFNNNGVYGGDRRGPDELTGPYKDDPAPTSFVPGAGYHQMMEAFGGKGYLVETPDELRSALSESFRARKPAVINVTIDPYAGAESGRMQHKN
The following text describes a protein:
Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLYSHVTLLMLRVVDVVAKTTVQQSARMLVAEIHGEIQIGALFPIHRQIAGSESCGEIWEQYGIQRSEIAMHTVNKLNEELPFKLGLSIRDSCWTERIAMEQTIAFLREGVAQCSCCQTPGCNKKSVPVVAVIGPGKSSSTIAVQNLLQVFRIPQVGYSATTPDLSDKEQFGYFLRVVPSDVFQAQAINRLLHHYNWTYVAVLYSAGNYGEKGFESLERLIAHRSSSVCIAYSEKIKTLASDNEYRQVLTRLDSQNSRPQVVVCFCEGASMRQFFKAQKHLADGKMQMKRFQWIGSDGWADRNDVVEDLEEEAEGSFSIRIHAPKIPGFRQYYTALHPENNTMNPWFREFWQQKFNCQFAVSKEDKNNENIRICSGDENLDEQYKEDPKLSQVINSITVVALGLKAMYQDRCRDNSTLCTEMLSRNGTLLYEYLLNVTYSDQFKQPVYFDRNGDPPAWYDILNYIGTKDLDNPYNEVGSFKSINDYGVEELDMTARSMFFDKTEILPESVCSRPCGIGQRQRETMACCWICESCLDMQFVNKTTNQCMNCSLGSWPNANRTGCEDIIPEVVSWTSFGHILALVLAVTGIITSLATLAVFLRHNSTPVVKSTTRELSYIILSGLVACYAVSFALLATPSSSSCFITRVIPPIAFAVVYSALLTKTNRIARILAGSKKRILTKKPRFLTTFSQVVITWILVAVQCVIVGVGLMRDWPDATYAKYALPRKLILECDTETKSFLIPFFWDFFLISLCTLYAFKTRNLPENFNEAKFIGFTMKTPRIMKKRKTLVFRYCTVVVWIAFLVLHMGTTHKALVMSFSYSLSASVALALLFFPKLYIILMHPEKNIRASYTTTKLIRCHFGNSQAAYDSTSKQQHLGSKTTARTSVQSGSASKSSSMGGGVTRTASVHVPVSRGSTHSTDASTQTEGVFNLTIHSHLIISAASKFSRSFSIVGRKKQGLDDDVQQLVDACRRYQDEKINSSAANLLLEEAEDEVGALLADSIENSMRTVLSTVAGKAVVPLVPIVPMVPVLPVVPAVVSIPTAPPQEDNFEQVTLKECESVVEWLVKKNMKRILSGSTHSSC
The following text describes a protein:
Function:
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
HRFEDFPGLRRRRPQFRKIKLKSGMLTRRRGSTCSDITASLHKFPVQYDHSPHEAFIELQELTGKDQDMRWKETARWIKFEEDVEDSNRWSKPHVASLSFHSLLELRKGLERGTVLLDLEQFDLQSIAEAIVDNMVITDQLCKEDSDRVLSALLVKHKHQYQEAGNLPRRPSFYNLKTFTPNLSRRNNEEDKNSVKMVVTQKVPVDEETDMIRLKIDDNIDVGSHTNQESDVKARVPEDAEATNVLVGTLDCLKNPVTAFVRLAKGCYLGNVTEVAIPVRFLFVMLGPETQSDTYHEIGRSIATLMSDQVFHDLAYYSESREDILMAINEFLDDTVVLPPGEWDKQLLIPVLLSQSKTMAKRRKQAKEINAIATQAAEEEDNPLKRTGRFCGGLIQDIKHRSKTYISDFKDGFNWQCLLVTVFLYFAVFAPNVAFGGLLAEKTDQWLGVSEVIFASCFCGLLFALFSGQPLIIIGATGPVMVFEQTIFKFCEQSNIEFLPWRCWIGFWVLVILFLVVAFEGCFLVRYFTRFTEELFACLISLIFIYEAINFLYKVFKKNPLSRDPVTNLTNIDPYIKENIVPVTGEPNTALLCAILMFGTYFVAFYMRKFRNSHFFGKKARRLVSDFGIAIAMITMVIIDVAIRDTVITPKISIGDVTKVGFHPTLKTKRGWFINPMGLVDSMKAGWVFAAIIPALFVGILLFMETELTGVLINKKENCLQKRPGYNMDLLLMGVITLICSLFGLPWMCPATVRSVSHFNALSVWSTSHAPGEKPYLVEVREQRITNILIHVLTGMSILLAPVLHHVPVPVLFGVLLYLGLSSLSNLQLINRLIMMLMPPKHHPDVRYVRKVPTAKIHGYTLIQLACLLVLMAVKLTILAPSFPFFIICLIPVRRLLGKVFSQHDLEELDNEEDDYDDSDIDEYDTLIMPI
The following text describes a protein:
Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MAQLSGLELAAYDKSPVHAAVARRDHITLQRILSKLPRPVKAGEVTTEAESIAAEERADEISKVIDRRDVPGRETPLHLAVRLGDADAVEMLMSAGADWSLQNEQGWSALQEAVCAREEGIAIIITRHYQPMAWAKWCRRLPRLSATMHRMRDFYMEISFHFESSVIPFIGRIAPSDTYRIWKRGSNLRADMTLAGFDGFRIHRSDQSFVFLGDGSEDGKLAPGTLCVLTHKDKEVANALEGAGVQPSENEIAQEVAAMSRTNMYRPGIDVTEAELVAQTSWRRQEKTEMVGAWKAKVHDMHHVQVSVRSRRVPGAMTDEELFALDSDRVDTEADEDYSNLLTTAEKEQLENVLKAEHLDENRTGGAERLDHELQNGNFVYLNEDSDDESDSHLRQSPHENGNGELLGSSKDEKRSRWYAWGKKSVKASKKLDSLSDKGSDSGHSSAEAPRKSKQGPGLPTPDSQLKLLKQRKSVDGRRSVDSQLAAYENQNRPSVDRRPSNVDDLLSAKGKGKELKSGRHSTSSKELIKSKSRRGTPKPEATSESEYKKGLRPILWLTPDYPLKTEELLPLLDILANKVKAVRRLRELLTTKLPPGTFPVKVAIPVVPTIRVVITFTKFEELKPAEEFSTPLSSPRHFSDAKSEADAAPAPSQGSWLYWMRGAPGSGKSATVSSLEEQLEEEADPFMIPPNYRWIDMEEKKRRLREKKGRSKKVKKPPRPPSSQDVDTNN
The following text describes a protein:
Function:
Probable transcription factor. Binds a motif with the core sequence 5'-C[ACT][TG]G-3' in regulatory elements of target genes. Many putative target genes show oscillating expression levels, perhaps as a result of rhythmic variation in accumulation of grh-1. Plays a role in proper cuticle formation and/or barrier function and is required repetitively during development, for successful completion of each molt. Involved in modulating lifespan. Plays a role in defense response to bacteria. May act upstream of the p38 MAP kinase / pmk-1 pathway. May act downstream of the insulin/IGF-1 receptor signaling (IIS) pathway.
Subcellular Localization:
Nucleus.
Sequence:
MSFQLDQSTSVIKTAPPGRLEFKNEPIDIASSNIQDLAKMQTLDGYYQQTSLQLPQSQQYHRMYENVYNNQQILYAQTQNFQYPSTLLTNGSLAQTEWRGQQMDTSAYSNTGYSRSSTSQQPQYTQQVTENERIVYKPVDMPSPVDSGIGGDISILNPKEEFFTSADGGSMLERSSERTLSHRDSPLVIPKLYNNLGFQYVLEAPISTSVRRDDDRMTYVNKGQFYTVSLEYTPDLNKCLKSQTVKSQLMVVFREDKTYEEEIKTWQSWHARQHVSKQRILEIDSKNSSGMIGQIEEIGNNAVQFYWNPSDPSGVRISIAVQCLSTDFSTQKGVKGLPLHVQIDTYDGENDKVPFHRGYCQIKVFCDKGAERKLRDEDKRAQKRKVQEYTAGALPGGRKKSDGEYHDQCERSEFYHMRELDKPAALFIAPEEFEPRYVDSTSLSFDMSEIEPIPTKRPRTSERIMLYVRKRDEQIYQPLHVVPASLSGLALAIANKFGADPDKMSGVYKRCAKGITVKVDDEMLRLYCNEDTFIIDVEHATDGSTAATLIEVAPTNPNSYSNS
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Sequence:
MSTTASTLPPAQKKPINNMESLDDANNSPFSKPASKPSTASSIAVSDAPQGYELEPWPTSAVEDPNQYRRGGHHPILLGDHLGPSTNPSRFRVFHKLGYGGFGTVWLCQDMDEMRNNKRWKWRVVKVMSAKASNLKGGNADLKVMEMFEGVDRELLKMKGVSIPMESFWVEGPNGRHLCLMMEWLGPETTGLARCIGQCDGMMKDICFQLLEAMEFIHSKGLCHGDFRPQNILLRLKDGVDEWSEEQLLAVLGEPERAAVVVWDDAQEPQPVTGNPSVPEYLVGCGDIAYGSGLVSTKIAVVDYGVAYPFSDHPVRCTSGVAGPYASPEDLTLQQELIGVKADIWSLATAMFEIRFGFPPFGTNNHAPSSIPSMEESMGPVPPPFRATVREWYKLPAETEEELQDKSNSELSYVTTKPEELEKNRKYHLEERGAKDPMIFRILYPRSTNISPAQAEDIANQAKSNPAQLPLWTPIPRNPDRLAYYTRKDYLKLVPPKEEVEVFWDLVMSVFKWQPEDRATIEQIMEHPWFEGRKKRRDAVARPNLTTSESGIVCSISTKLGQAKANISNWFNILFWDKQKNKTKGSNTLSRYLWKPTCKTFGKISGVPIAIFWLLMIIPAAWLIKRRIDRGRNVFSPSSVRGLRH
The following text describes a protein:
Function:
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to camsap2 and camsap3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associates with the minus-end of microtubules. In contrast to camsap2 and camsap3, does not form stretches of decorated microtubule minus-ends.
Domain:
The CKK domain binds microtubules.
Sequence:
MVDIGLSASGDSTRRKMEAFADCAVEVVPLDLYDSFRAKIAANLQWICAKAYGIDNVPEELKDPFYTDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVAALQGHQPVIQALSRKGIYIMESDDAPVSESDLSCCPIKMSAHMSMIDALMMAYTVEMISIEKVVASVKRFSTFSASKELPYDLEDAMVFWINKVNLKMREILEREQRIKQQVIESPSHPKVRYRRDHPSSRHLPYFPILEDLTKDISDGAALLAVIHFYCPEQMKLDDICLKEVTSMADSVYNIQLLKEFSNEYLNKCFYLTLEDMLYTPLVLKPNIMVFIAELFWWFENVKPEFVHPRDTQELKEAKIVMHPKTSRPQVPISNATKRSFLASPGSTTDSQATAASESCSSNYLQAEDAENGKGCAVFSPSHPLLPLRQKQQKSVKPEESLNHRDQANSLTRADGQPMASIIAWKEKKPRPLSQTFALHHAADDVESTSGDSISLARSISKDSLASNIVNPTPKHQSYPTPIKVLPKSLLGNVDIEDDEEELVAFIRSDDASCPGDLELQSVSSRASSQMSTSRLRRPADLESKPDSFFLEPLMPAVLKPAKEKHMVPKSEEYGEGKQKGFSSKRQNEGNQSFSRKKIINNHTGHDLNRTFTPLSSLESDPLRTDPVQLSIESGNGNFRPLATSSVESSEHGGGFFLHDLNADDDVEDKPSAGNLIMEDPHKPDTTWTVLRPGSENLDVGGCEEVAVSRPVGKYIGEEESVKLQEDLKLKEHDDKDDASGRSSPCLSTISQISSASMASGSMRMTSFAERKFQKLNSYETKSSTSSSQKTTPDGSECCPPPLTTWKQRREQSPGRQNRDHANVLASELVQLHMQLEEKRRVIEAQKKKMESLSARQRLKLGKAAFLHVVKKGKPETVAQPVKPEHGFRDYTKRTPEDIDTVSVNAKVEQYLESIDPGIVSSEVQEAFTDPKLKDPALLEADICNLMADANPEDIDSEIDVNECDLSIEKLNETISTLQQAIMKISQQQEMLMKAPSMAVPPLPSSSQDHKLKPSVQFVEPISPPGMPIVRKTTRFGQGRNARSLRVTEQKLAKEKMQSSSRVITPTNSIETVPHLKSVQPLKSPSVPTEESPVEVVPEQGSASQDKPTTGGFRLHNDNSQRTFVLSTSKDANIISEQMHREVISSSRVAGVSTSESSGKENVPVDERHKSSLIEVDLSDLKEPDEGEEESDHPEKTKDIISDDQKSGVGFFFKDEQKAEDELAKKRAAFLMKQQRKAEEARLRKRQLEAEVEQKRDDARRKAEEDRIRKDEEKARRELIKQEYLRRKQEQILEEQGLGRPKPKPKSKKTRPKSVHREESYSDSGTKYSSTPDNLSSAQSGSSLSLASGATTEAESVHSGGTPSHRVDCVDAPSGMGRHQSRNAERDWENASTASSIASVAEYSGPKLYKEPSSKSNKPLIHNAISHCCLAGKVNEAIKNSTLDELEKCDSNHYIILFRDAGCQFRALYSYYPETEEICKLTGTGPKNITKKMIDKLYKYSSDRKQFTVIPAKTMSASVDALTIHNHLWQAKRPALPKKNSLGK
The following text describes a protein:
Function:
Ion channel involved in potassium tellurite resistance.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLHFAHIFQNKVHTMNITKPFPLPTGYFGIPLGLAALSLAWFHLENLFPAARMVSDVLGIVASAVWILFILMYAYKLRYYFEEVRAEYHSPVRFSFIALIPITTMLVGDILYRWNPLIAEVLIWIGTIGQLLFSTLRVSELWQGGVFEQKSTHPSFYLPAVAANFTSASSLALLGYHDLGYLFFGAGMIAWIIFEPVLLQHLRISSLEPQFRATMGIVLAPAFVCVSAYLSINHGEVDTLAKILWGYGFLQLFFLLRLFPWIVEKGLNIGLWAFSFGLASMANSATAFYHGNVLQGVSIFAFVFSNVMIGLLVLMTIYKLTKGQFFLK
The following text describes a protein:
Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MSRRETGRVNQKKTKEEKVQRGEAIREAVTKFDRIYVLRFSSESTEPQTALRRNFRSSNLCRDKKTIISHSIGATPETEARPGLSGLLQYLAGNTGLFMTNEDDNTVREYLQSMTQPEFAKAGFIATEDFTVPEGPLPQFTFSMDGYLRELGLPVQLENGTIFNVRDHKVCTAGEPLTKNQAQLLKHFNIKMDTYKVEPVAVWYNGEVKAF
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAPPTRTSSENRHSGVSHPWRIVDDCGGAFTMGVIGGGVFQAVKGFRNAPVGIRHRFRGSINAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSGPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFRNAPPFLEDPNQLTPKEGAPAPGYPNYQQYH
The following text describes a protein:
Function:
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Has an essential role in mediating growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae.
Subcellular Localization:
Nucleus.
Sequence:
MSDSDDNANNLPDGQMENGHISVDSQFNFSRERHSGTNQASDQFDIDLPTSHRYLGKLDNVTGYTFYDDGEVATLAAIQTNTLVFPGFTLPLVLNNDLEINMLQRHTSKKNAFVLLTPDKTFKGFFTYGVIMEIFETHLRNSVLYLKARSRQRCRLVPGKEIKTLIGDLYQVTVEVMLEPPPTSPLCNTQLNSLKIRKLFNCTEYREFYKYRKFRLFHLSQFPLASWVYDKHEICFLHHKLVNALSNYYLIEFIPDDPVQLSYWFVQNFQLRHEERLRIMVLRTAVERLRLELKYLNMKRLICCAKCDAEIAQHSNVFPMSKDGVQSNYCNPEGYVFETVTVSKATNFTLFGSPSAQFSWFPGYSWTIMHCKMCSSHLGWKFSSVNLKPAVFYGLAKSGFDIKIVKEESEVL
The following text describes a protein:
Function:
Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2-aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoyl-CoA. Beyond its thioesterase function, is involved in the regulation of diverse genes coding for key virulence determinants and biofilm development.
Miscellaneous:
MISCELLANEOUS: As mutant can produce wild-type levels of PQS, it was originally thought that PqsE is not involved in HHQ/PQS biosynthesis. It was shown later that the role of PqsE can be taken over to some extent by the broad-specificity thioesterase TesB, explaining why the pqsE deletion mutant still synthesizes HHQ and PQS.
Sequence:
MLRLSAPGQLDDDLCLLGDVQVPVFLLRLGEASWALVEGGISRDAELVWADLCRWVADPSQVHYWLITHKHYDHCGLLPYLCPRLPNVQVLASERTCQAWKSESAVRVVERLNRQLLRAEQRLPEACAWDALPVRAVADGEWLELGPRHRLQVIEAHGHSDDHVVFYDVRRRRLFCGDALGEFDEAEGVWRPLVFDDMEAYLESLERLQRLPTLLQLIPGHGGLLRGRLAADGAESAYTECLRLCRRLLWRQSMGESLDELSEELHRAWGGQSVDFLPGELHLGSMRRMLEILSRQALPLD
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MHQVDRSSTRMIDCIIDLHAALNLLKEVQVDAIIGPQRSTQAEFVIGLGDTAKVPIISFSATSPSLRPQTPYFLQTALSDADQVDAVAAIVKYFRWNQVVLVFEDSDYGYGISPYLANAFRQVNTRVSYRSVIPISASDDFILQELYKMKTMQTRVFVVHLSSGLASRIFLKAKEAEMMSEGYVWIVTSGLMDLFYSLDSKVVESMQGVLGVKPLVPRSSKLDSTTIRWRQKFADDNPGITPQTEMSLYGLWAYDTLWALAMAAERTRFKEPSSLPNATSLNSTDMFITEISQTGPQLLAAMLETEFQGLAGNFKLVNGQLESSSFQILNVNEKGLREVGVWTPLLQSSSQTNANMTGFVGEKLENVIWPGESTNVPKGWEVPVSGKKLKVGVPVEIGFSEYVKVERDPRTNGTKISGYYIDLFDSVMDALPYSIRYEYVPFQRSDGSYDDLAYQVFNGNYDAAVGDITITGTRSEYVDFTLQIEEGGVSRTQKIEYENPNDEWFFLKPLTLELWLTALAMFILTGAALWLLEHRHNEDFRGPFPNNFGLIFYVPFMSLVFAYREKIVTNFARLVVVVWIFVVLVLNSTYTASLSARLTAIKLLKVDTGVKTLIRNGDYVGCREGTYIIEFLKRLGFDESKIRTYKLPEDFDTALSKGSKNGGITAFFSRTPYMELFLTKYCNKYMKVGSPYYTEGFAFAFPKGSPLVADVSRAIIKQTDNHKISEIKDRWIKQSACNEDDISNGSSTNIGLKSFKILFGITGGITGICLVLYMVSFFSSNKVVVKSIYNNSRTTTWSKIRKICKIFDEKDPKSFPNRDARRTYSI
The following text describes a protein:
Function:
Multifunctional enzyme involved in the degradation of plant cell wall polysaccharides. Displays endoglucanase activity against carboxymethyl cellulose (CMC) and barley beta-glucan. Also catalyzes the deacetylation of acetylated birchwood xylan and glucomannan, with a preference for the latter, and of the synthetic substrate 4-nitrophenyl acetate (4-NPAc).
Subcellular Localization:
Secreted.
Domain:
Contains an N-terminal module that displays cellulase activity (CtCel5C), a central type I dockerin module (Doc) that facilitates the integration of the enzyme into the cellulosome, and a C-terminal module, CtCE2, which displays dual activities: it catalyzes the deacetylation of plant polysaccharides and also potentiates the activity of its appended cellulase catalytic module through its non-catalytic cellulose binding function.
Sequence:
MKKIVSLVCVLVMLVSILGSFSVVAASPVKGFQVSGTKLLDASGNELVMRGMRDISAIDLVKEIKIGWNLGNTLDAPTETAWGNPRTTKAMIEKVREMGFNAVRVPVTWDTHIGPAPDYKIDEAWLNRVEEVVNYVLDCGMYAIINVHHDNTWIIPTYANEQRSKEKLVKVWEQIATRFKDYDDHLLFETMNEPREVGSPMEWMGGTYENRDVINRFNLAVVNTIRASGGNNDKRFILVPTNAATGLDVALNDLVIPNNDSRVIVSIHAYSPYFFAMDVNGTSYWGSDYDKASLTSELDAIYNRFVKNGRAVIIGEFGTIDKNNLSSRVAHAEHYAREAVSRGIAVFWWDNGYYNPGDAETYALLNRKTLSWYYPEIVQALMRGAGVEPLVSPTPTPTLMPTPSPTVTANILYGDVNGDGKINSTDCTMLKRYILRGIEEFPSPSGIIAADVNADLKINSTDLVLMKKYLLRSIDKFPAEDSQTPDEDNPGILYNGRFDFSDPNGPKCAWSGSNVELNFYGTEASVTIKSGGENWFQAIVDGNPLPPFSVNATTSTVKLVSGLAEGAHHLVLWKRTEASLGEVQFLGFDFGSGKLLAAPKPLERKIEFIGDSITCAYGNEGTSKEQSFTPKNENSYMSYAAITARNLNASANMIAWSGIGLTMNYGGAPGPLIMDRYPYTLPYSGVRWDFSKYVPQVVVINLGTNDFSTSFADKTKFVTAYKNLISEVRRNYPDAHIFCCVGPMLWGTGLDLCRSYVTEVVNDCNRSGDLKVYFVEFPQQDGSTGYGEDWHPSIATHQLMAERLTAEIKNKLGW
The following text describes a protein:
Function:
Cyclin-dependent protein kinase (CDK) inhibitor that restricts cell proliferation and cooperates with SIM and SMR1 to promote endoreplication during leaf development.
Subcellular Localization:
Nucleus.
Sequence:
MSKLLETLEEEKTVEQKPRSQEEEDHQDSSKKEELLESLCTPTSSDHKIPEVETCPPPPRKRPREISLTKKTRLSKDLRFFEATDVGSQEVETLFVHEPNHVRKKRRSNSA
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MADTVANTTEYMEFLLMGYPDEQVLQTLCATLFFLLYLAALVGNLLIITVTTVDKHLQSPLYFFLKNLSLIDICYISVTVPKSIMNSATNTHSITFLGCVLQVFCVIFLAGSEFALLLVMSYDRYAAICFPLHYEAIMSKDACVQMVAAAWLSGCVYGSVHATGTFSVRFCGPNVVYQFFCDIPSLLRLACFGDEILEYVFIITSCCFAFVCFILMVISYVHIFTIILRIPSTQGRFKTFSTCVPHLTVVTLFLSSGFVAYLGSTAKSPSSLNVFMSVFYSLLPPSLNPVIYSFRNSDVKVALHNIFGEKMITYL
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MASKPHILLFGVGSVGAIHLLQLQRAGCTVTAVCRSNYDVVKEKGFALRSVRFGNVTYRPDHIVRSIAECPKDTVYDYVLVTTKCFPGSKPSVADLIRPAIIGRPETAIVLAQNGIEIEKEVADEFPENPILSGVVYLPTTQTSPGVIDYPEMLNLIELGTYPANAPPTHKAAASKLVDLMNQGGGEAKLHDDIQIARWTKLLINASWNPICALSMCSDGDFLLSSEPFALELVWGIMMEIVALAKKLGIPQVDEEAARVRFQIATRRAKEGTGRDPSMLQDVKQGRLFEVEAIVGNTVRLAREHGVSMPRLETVYALAKGRYEALSRK
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MGLENRYYYEEGIILFKKKVGEGDLLLTIYGKEKGKFLAIARGALKIKNRLRGKVNIFSIGKGYFVKRREVDLLIFWDSYEKFFEIIKDVDKFIILSKYLKKADKFIPLEVKDLEIYEYLYKFLKNWNLINKYSGDVFLIKLLQKLGYISKVELKCKGCDKDLLKDEYVYFDLDNRKIYCEDCRTLKSLKIKSEEVIKFNEILDRTFDELIMGETGFSDKIFNLIDRMIERIEQEV
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
MELSRLLHRYHSGSSTVSAPATASSNELRGTRREEGLPPPPAAAAAAAAGNSTVAKAQAVIAAAAALKRHANTSASLSASSASSPRPEAADGAAGSPTHGSKAATSQACSAPSSSSDSRHHVQVYREHCTIGWSPDEFYSVVADVEHYSAFLPWCAGSEVHTTRRVRVPRDALRLPPSPAAASPLATGSEAAELELVDAIEMTTTLTIGFSFFKEQYTSRVTLYPGRKIVAALYDEEDVDVEAAPQNTSRASSAAVASSRDSNSALGTGSGNGLVLSFFRKAASTAGVAAKRSILRHLRCEWEFAPVEGKPNTVDVLFFVSFEFKNPMYRHMIMNNVVGLMTRSFERRCESLYGPPSATKVSLPVLS
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MFQIVLIVTIILSSSSLSSLNLSSPITSSSSSPSSSFLNLTKILYSSHTFFKAASEFHSLGIDSEIDTRYSTTVFVPDDKAFANATVSKRYESLSDDNKYFVLKCHMLKEYLPPAVLRKIANDMHLQDTVATEIMGQATYRINITVMVNGSVAVSNNIVRALVTRTLYDRSPIAVYAVSKVLMPKELPALITSDVTAPNVYCFKFSVVLILLVLWI
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MNGDEVRARASELPAEPGVYQFVARDPDGTADGERVLYVGKAVDIRDRVRSYGDPRSERIAGMVARADDVTVAVTDTETQALLLEANLVKRHQPRYNVRLKDDKSYPLVQVTSHREAPRIEVTRDPDPGAAAFGPYTDKGDVETVVKAVRSVYGLRGCSEHKYRDRERPCLDYEMGLCAAPCTGAISEREYREAVESATRFFEGETGALADPLRREMAAAAQAEAFERAANLRDRLAVVEGFHEGGGAAVAAGDADAGASTDVLGVAVEGDAATVARLHAEGGQLVERDQHRLEAPQGEDRVAAVLAAFLVQYYAERDLPERILLPEPHGDDEVAAWLDAADVAVGVPGAGREARLVELALKNAHRRAGGGDELGALADALGVRRPERIEGVDVSHAQGREVVGSNVCFVDGSAETADYRRKKLDEENDDYANMRRLVGWRAERAVDGRDDRPDPDVLLVDGGRGQLDAALDAVEAAGWDGPDAVIALAKDEEVVVTPDRTYDWGSDAPQLHVLQRVRDEAHRFAVAYHRTLRDDVTTALDGITGVGPELRARLLGRFGSVAGVRQASVKDLRDVAGVGEATAETIAKRL
The following text describes a protein:
Function:
Has antimicrobial activity against Gram-positive bacteria (C.glutamicum ATCC 13032 (MIC=1.6 uM) and B.subtilis ATCC 23857 (MIC=1.6 uM)) and Gram-negative bacteria (E.coli ATCC 25922 (MIC=12.5 uM) and P.aeruginosa ATCC 27853 (MIC=25.0 uM)). Displays very low activity against the Gram-positive bacteria S.aureus ATCC 9144 (MIC>100 uM).
Miscellaneous:
MISCELLANEOUS: Displays cytotoxic effects on human melanoma cancer cell line A2058 (IC(50)=4.1 uM) and the human fibroblast cell line MRC-5 (IC(50)=7.5 uM).
Subcellular Localization:
Secreted.
Sequence:
GIKEMLCNMACAQTVCKKSGGPLCDTCQAACKALG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MGLKKQKKFPRVQTESHDSLRGTVLLGFFTSTTGSLSDTPISSSPPSPASATNPPPSAGISALSHSADQDDAIRLLKNSIVSRLQGLKRKPNFWIELMDSQTQNASLLRLQTVEKRIVRVLELAGGVMEEFSNPNGPRKELVNSHCSEFMQIIKDIQVTLREEIKSACEYRPFEKCDYIARVSNEICCKKLEYVVDKLDGMKEIMDQYHQAT