lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Antitoxin component of the hybrid type II/IV toxin-antitoxin (TA) system DarTG, which plays a crucial role in controlling bacterial growth and bacteriophage infection. Keeps the toxin molecules in check under normal growth conditions. De-ADP-ribosylates DNA (probably) modified on thymidine by its cognate toxin DarT, which neutralizes the activity of DarT. Experiments in which DarG levels are depleted lead to cell death; expression of wild-type DarG protein from M.tuberculosis or T.aquaticus restores growth. Cells depleted of DarG are more sensitive to bedaquilline (targets respiration), DNA-damaging drugs (mitomycin C, netropsin) and transcription-targeted drugs (rifabutin and rifampicin). When depleted, a DNA-damage response is induced and mutability is increased. In E.coli the macrodomain alone neutralizes DarT toxin from non-cognate T.aquaticus. The same domain de-ADP-ribosylates genomic DNA.
Domain:
The N-terminus macro domain alone is sufficient to neutralize DarT from non-cognate T.aquaticus in E.coli, DarT in M.bovis, and to de-ADP-ribosylate DNA in vitro. The C-terminus is a region interacting with the DarT toxin ssDNA binding region.
Sequence:
MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFTAYEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRVIRELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVEGLRMTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFTPGRYGPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAAADRVSAAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGRIYSDDRIGVALDRILMTA
The following text describes a protein:
Function:
Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles. Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones. Inhibits ARHGAP31 activity toward RAC1; Plays a role in synaptic vesicle endocytosis in brain neurons.
Subcellular Localization:
Cell membrane. Cell projection, lamellipodium. Cytoplasm. Membrane, clathrin-coated pit. Nucleus envelope. Recycling endosome. Synapse, synaptosome.
Sequence:
MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQSLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQQLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKLVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWIAYALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRADSFFEENCRYVPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVFNRSSQTYAWGANDVLNVFSHVSNGGEINLRFYNHDLDFSPGYDAYEEDEWVFKRVKLLLQQKREALQRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGMTDSGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNEGPAMPLHELEQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAEAIKRYKDTIVQLQKKREYSLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFLGWMFYIYRLLSRNRASKVELVLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFVWLKALQPWNINFSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIALCFCVFACYNSWENFQWKSRDFFSWLALVLILSCFPLLPLSVGYQNGYLLGAGVIVIFTNSFWNSKSRLCYRNHTKYSNALILLQTILCAYLHSNGINIPIPLKLASWLYLVYAFASILLSKESRLDLRLAQIGFNLGSLYATLCTSYEAVFVQLLTIELNISLRAQSARAERSVLRLAFTLLLYTFFSLFGSGNIASISSFDPNIARCYLSHFAPFVIMGLVLLKLLVPVVLIMSVIYANSEFVRQHEEQIFICLLLICDVMGLNFLFLVRNQGSWLDIGTSISHFVIMEVTTLVMLVIFYTAKQLLRVIPWEEIDFKMLPLRLIHWDVISAKHH
The following text describes a protein:
Function:
Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function. Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development. Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKHIINSYEHTNNTARNNSDCPDVVVPEEIFFTISIIGVLENLIVLLAVIKNKNLQSPVYFFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSLESTADDIIDCMFVLSLLGSIFSLSVIAADRYITIFHALQYHSIVTMRRTVITLTVIWMFCTGSGITMVIFSHHIPTVLTFTSLFPLMLVFILCLYIHMFLLARSHARKISTLPRANMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELREAFKKMLFCNRY
The following text describes a protein:
Function:
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
Subcellular Localization:
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MIIAIQTLIFFRQSLLTALDRLLRPYFQKFALSLTKSSFESDDDEPDENVFAEYDDEKGVIFFPPMYVQRYAAIVDCLLDERWSGKLDKVVDLGYHDMSFIKYLKEVSGIKSILGVDLETIPLQCSSDLLSCNEYAPKRETPLQISLLQGNAADPDYRLIGCDAVIAIEMIEHMLPHDLERLVHTVFAFIKPWIVIFTTPNDFKDVITGDINICKFNEKYLHRLNCTTLQVKKFSKTTQGLMAKNKVDALVHTREVVEEIKHLTKMLNFNKSGLNQQDEKTHIWYNFNWGENAPYWNQYYKIVREYNYPFETKSDDCRILDLISDEMNRLIDLQYDDILSVDLNKLEIPLQHLMQTVQHITDDVENVRELLEWNGYEVVDDMVIYSRLAIDNVTIDSQIDDWQENESVSDVKKFN
The following text describes a protein:
Function:
Represses translation of the downstream SCRIB protein. Translation of oSCRIB hinders SCRIB translation but does not completely abolish it, probably due to leaky scanning which allows the ribosome to bypass the weaker oSCRIB start codon and initiate translation at the stronger SCRIB start codon.
Miscellaneous:
MISCELLANEOUS: This protein is produced by a polycistronic gene which also produces the tumor suppressor gene SCRIB from an overlapping reading frame.
Sequence:
MRTEPRPPAPSPPSAAAGARAAHPHHAQVHPAVALQPARGVGGQAALFAAGRAGGDLPLQPQPGGAAARRQPAARAAQAFFPAAELAQAGPERQRDPAVASRGGQLHAAGGAGRVPERYP
The following text describes a protein:
Function:
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Subcellular Localization:
Cytoplasm.
Sequence:
MGARASAFIWPYADIQYGFLDRELGIDNLHALAAQGRHRAVRKLLRKGLDPNGRRLEGASGAEDDERGDSPMICATRGVPGNKDQKRHVKTLEVLLHFGAKVNQPNLLNQTPLYIACEGNVVRVATWLLQHGADVNINCKTGISPLMCAYRNQNVALATLILEKGAVVIRPPATFSYIRFPELADELGTLEAPANDKSATVLHSALQQYIDHEAERRARVLEDAHEAQRLEDQRLYREQLANEGAKRKARRRRKRLEAQQRRNLPPVKALGTAVDTSEIERGDASSRSANQGDGLLLWEKKAMSTRIRSAASGRPKWVPRRIYCTQDHRKESEHDFMHQCKKLNDSLELERSRRLSVSENSTQEDCAVMPGRVSQHHQEELGKFLKFFRSRLKTHLENVEADFEDTRSDRLSSEEVYSQKDIQEAIKSLCFAVKANIRSELQDTINMMALLLRQIFMEAEDSELALDLDIAMVEDKELLERVEQLSVSEWTSGDSRGAAAIGALPRNNAKAQADVEAKEKLEKRLQHEQEQHEDEIRAAKLTSKQELAALEAAHTKELRKMQRKIEQANERVEELERQVEDGRQHVAQTAQFQSMKRMVTAKNQQLQDLRLRLQRYEPDYAEDDGETKNADDD
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron.
Subcellular Localization:
Nucleus.
Sequence:
MDFQHRVGSKIGSGGVASSSESNRDRRERLRKLALETIDLNKDPYFMKNHLGTYECKLCLTLHNNEGSYLAHTQGKKHQQNLARRAAKDAKDAPAQPALEKARVDVKQFVKIGRPGYKVTKQYNQEAGQQSLLFQIDYPEIVDGITPRHRFMSAYEQRIEPPDKQWQYLLFAAEPYETISFKIPSREIDKSDDKLWTQWNKESKQFFLQIHFKADIKQQPSRNIPQSAIVPNQRNIPSQNPLNPYSAHYLYNINNRSMYNSIDWRSHAAWRLARIQCANAAHWLAIKRCLALS
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MKEEEGFPEDEATESEKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITVAMKCQYVGADVLDLAETMVASADGLVYEPTVFDLSPQQKEWQRMLQLIQSRLQEEHSLQDVIFKSAFKSASTALPPRAIPHPRGHAHLAALVNHESYNFSHRIDHLSFGELVPAIINPLDGTEKIAIDHNQMFQYFITVVPTKLHTYKISADTHQFSVTERERIINHAAGSHGVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIVGGIFSTTGMLHGIGKFIVEIICCRFRLGSYKPVNSVPFEDGHTDNHLPLLENNTH
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDDFTNSFLQKLMPKKYLKEINEDDIQQKYRKINLFNTIKTSKVICSQKRRGLPTKQKKKLKLLSLDENEKIYNLYIPLHELWLDYMNTLLDGCTSDKKEMGRRILKADLHGCEIEVCKSKCPSLVGLKGIILIETKNTMNIITRSNEVKKIPKHNCLFSIKVLGFKITIFGNNLQFKASERSTKSFKNKPAIEF
The following text describes a protein:
Function:
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Subcellular Localization:
Cytoplasm.
Sequence:
MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIASIPGCPGKTGRSF
The following text describes a protein:
Function:
Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSTRQVLQVFEQYQKSRTSFVQTVAELASRPQNIETLQNAGVMSLLRPLLLDIVPTIQQTAALALGRLANYNDDLAEAVVKADILPQLVYSLAEQNRFYKKAAAFVLRAVAKHSAQHAQCVVDCGALDALVICLEEFDPGVKEAAAWALGYIARHNAELSQAVVDAGAVPLLVLCIQEPELALKRIASSALSDICKHSPELAQTVVDAGAIAHLAQMILNTDAKLKRQVFSALSQIAKHSVDLAEMVVEAEIFPAVLNCLKDPDEYVCKNVATLIREIAKHTPELAQLIVNAGGVAAVVDYVGDKSGNVRLPGVMMLGYVAAHSENLAMSVIVSKGVVQLSISIAEESEDHIQAAAAWALGQIGRHTPEHAKAVAVANVLPKLLQCYLRPDSSEDLQTKAKKALKNILQKCTHLPALEPLLHDAPPNILKHVVGQFAKVLPHDAKARRLFVTSGGLKKVQEIKAEPGSALHEYINTINNCYPEEIVRYYSPGYSDRLLERVEQYQPVA
The following text describes a protein:
Function:
Required for maturation of 30S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEKATEIANLLGPTVESLGLELLGVEYLPAPGGATLRLYIDVPLAEQPDRIINVDDCERVSREVSAQLDVEDPISGNYTLEVSSPGVDRPLFTLDQFARHVGESAKIVLKLAQDGRRRFQGQIVRIDTEAAAVVFSVDGKDVQIGFDNIDKARILPDWVALGLAPQKPNKPGPKKPGHDKKKPSNEPAAGKPRAE
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MVGIRKQLCLSSLSDTKKPKRSNPQETQQQPLRKVRILVNDPYATDDSSSDEGETKMRRIVRVVNFPPLLESATPSVEPTSVSSSEDSTKTISKKAAAAAASRPRLSKKPVGVRQRKWGKWAAEIRHPITKNRTWLGTFETEEAAHQAYKDKRKEYDALLATSNDSVSVSETSQCSRSSPLEQDTSASPPALKEEIKITTTPTAGVDSSSKEVLFGFNFAELPIPDLGFFAEEGQMGDLGFFTEEHDQLNLDCLFTDDQFDDFTMLGFEDSGPSELPDWDFPDAEFDSSFFFADQHIPLKSLAA
The following text describes a protein:
Function:
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
Sequence:
MEIAYFLGCIMNNRYPGIEKATRVLFDKLGIELKDMEGASCCPAPGVFGSFDKTTWAAIAARNITIAEDMGADIMTECNGCFGSLFETNHLLKEDEEMKAKINEILKETGREYKGEVNVRHFAEVLYNDVGLDKLSELVEKPLNLNVAVHYGCHFLKPSDEINIDNPERPTILDEIVEVTGAKSVEYKDKMMCCGAGGGVRSRDLDVALDFTREKLTNMKEAGVDAIVNVCPFCHLQFDVGQMEIKDKFGEEFDIPVLHLAQLLGLAMGLPKEDLVVDAHQVCVDECLEKLEELDRLAPGSG
The following text describes a protein:
Function:
Required for flagellum formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, cilium, flagellum. Note=ColocaliZes with intraflagellar transport (IFT) proteins at the basal body and in the flagellum matrix.
Sequence:
MSDDLVKILVLGPSKSGKSTVTNFLAGTRDTPTKEYHETNPLRVLEVEIALDDTRRSGRQAAGLKKAVVQLWDVGGSSKHQAGWPAIASNADGIIYVFNPEVKGSEKELLLWYKNFALNQDELDDDNNFKMRVTDGHSLIFSHHSSLPEFAVGDNAIPPMPKQLQGIRALETSLDYQSDNFKEAFDALVEQIIASRLAAEENDLLQKEREAKDYPRLKR
The following text describes a protein:
Function:
May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed.
Subcellular Localization:
Cell surface.
Sequence:
MSLFPQILLRLLFLAFTLKSTSNAEKHDKVDYKDFVRRDDGDTCLRYTTIYSQGEYETTITIPPNSYSNGVSLSNGTLLSTSSPLISTSGQFTSNNVSTTSSQRHNTKTITFFSGTSDYTSVYYDTTGTDDVVYEYHPSSERHKSTNDTWSTNLPTNPTTTAIYSTSGSSNITTPYSNRITNSNTSVNDITSKYLSVGTITLTTISGSDLYTSTFPANGTTSGTVEVVIPTAGTVTETAVSGSELYTSTFPANGTTSGTVEVVIPTAGTRTVTKISGSKFFTTTTDASGTVSGTVEVVLPTAGTNTMTVVSGSRFFTSVVSASGTVSGEQVIVYPTAGMVTETIVSGSEIFNTTYPASGTRTGTVEVVIPTAGTVTETEISGSELYTSTFPANGTTSGTVEVVIPTAGTRTVTKISGSKFFTTTTDASGTVSGTVEVVLPTAGTNTMTVVSGSRFFTSVVSASGTVSGEHIIVEPTAGVVTETVVSGSVGYTTTYPAHDTVSGTVEVVEPTAGVVTETVVSGSVGYTTAYPAHDTVSGTVEVVEPTAGVVTETVVSGSVGYTTTYPAHDTVSGTVEVVEPTAGVVTETVVSGSVGYTTTYPAHDTVSGTVEVVEPTAGVVTETVVSGSVGYTTTYPAHDTVSGTVEVVEPTAGVVTETVVSGSVGYTTTYPAHDTVSGTVEVVEPTAGVVTETVVSGSVGYTTTYPAHDTVSGTVEVVEPTAGVVTETVVSGSVGYTTTYPAHDTVSGTVEVVEPTAGVVTETVVSGSVGYTTTYPVQGTVSGTVMIVEPTAGYVTVTTSLGSSSYATTVATASGTSTGTVLQVVPSLFPGCNSKCTSSNAFRILVENDSISPSYLTYRESDGFGIASSNPSPAGSEGIFYYDSTLKRVVTCCDERPYYRTMEGDLAKTYFFIEDEGDGTYKFKLTYGAFSEYLDVKILADSTFFFKAMDSSSSTILNQKVRASNVYFKAVPL
The following text describes a protein:
Function:
Involved in forespore engulfment and required for anchoring membrane proteins on the forespore side of the septal membrane. Forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling.
Subcellular Localization:
Forespore membrane; Single-pass membrane protein. Note=Localizes to the engulfing septal membranes.
Sequence:
MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQSVSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAKEEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHADGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLNFMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESSTTEDTEQS
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPFSRYQIRNEFSLADPELYKAADKDDPEALLEGVAMAGLVGVLRQLGDLAEFAAEIFHGLHEEVMVTATRGHGLLVRVQQLESDFPAIERAFLSQTGHSAFFSSSGIGWHPNLQTEQNLITRGDLPRFVMDSYEESRGPPRLFLLDKFDIAGAGACLKRYTDPSFYKVEASSFEMRNTEAQRGKNVRKTKKKGSKWKNGETPDVFQPSHVKLHQLLLEERMQNGTSEPTRHVKLKKREIKFPFDTETGKGYMETLLTSPPEDKLVHEVPVRPMLETHDEGIMVNSPSQNGSPFESPSVDKSVSMEHMNNMSGIMIPELPENETEGDSGIEEEEEEVEEKHISVEGNHKVDDVSPDGYQSDDVVSEGENYVDALATMESEIETETELRTNSDANLEQIQSQFSDSQSGDEIENGSIKKKMETFSDSETSTTSTDNTPRSVTFASTEIPFRPRILPSQVSDEGVVLEESGSKESGLSEMSSSNQIDPEAIAASTNDDPSSSNLQSEDGNSNSTLEISQVEEQQPSGPTPSSEEVENCDADVEVKPSEEISFIPDTCSLLKEELTDDVLESKSDRDSDEIESKDDSNSDNNNYSNNNNNLPILEDEKESVNNSVTNPDEIDNNESKSLSTCEDTELDERKVESFNSEIEALTFADEKDEDADDDGENGPVIDDSDESVGKQESVITPELDSIPSESGEKKEPDVSTELDSVPSAAYDHSNIQSLDSIPTNENLDENLTVLEKTDENGDVQLQPDLDFESNQDVVESKSTNNEIQEPVYEESSMEDLPQLGNENISDEVNFNYPLAPVFTELNMLPPLSPPINLEEMPPLPPLPPMQWRMGKLPNNDDQQQNHFPPPFPQIMTPPSLPHQNEITENPNSQHDNHQDTEISTSTSTSHTEQAKVAEEQIVILPKPSIDVEEQQSQNVSTSGQESSVSSIHEGDDDERPNGIGIRPMKVQRPRTPLIDAVAAHDKSKLRKVSERARPEIQEEEERDTLLPLRKVSERARPQIPKEEERDTLLEQIRAKSFNLKPAVQTRPIIQGPSTNLRVAAILEKANAIRHAFAGSDEDEDDDDSWSE
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MKRPSCRGSSMAIIHDTSDQQEDNMRSYMDGGGAAAYEEEEEEVEDDDGGGGGGGGGGGGGLGEKKRRLAAEQVRALERSFEADNKLDPERKARIARDLRLHPRQVAVWFQNRRARWKTKQIERDFAALRSRHDALRLECDALRRDKDALAAEIADLRDRVDGQMSVKLEAVAADEHQPPPPPPPPPLAYNSKVVDGSTDSDSSAVFNEEASPYSGAAIDHHHHQTPASYDTAGFTSFFAPSTTLTSSLSFPSMFHASSHFDGHQELLVGGGGAGAVADADLGGAGFFAGDEHAGGLSWYGAEGW
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MNIKSLRKKNIQNMDQEEVYNRIKENVAHMDEIQRTMEKQQQTFFQMSLQSKQIAESMKKYSMDAAYFNSRIPITDCLSRASEWQNSISEVFNHLGNLLYDRTTQPLKQTISIQLEMVKEGKKKLKNLSTDTSKSSSANLKKDTEAFERTQKETLQLYNDSELALENSTVQTILSSFESYNDFFQRGVFQMSKIKSDIDNYKKIILETNKVAAKLRNYVPKKTFGIKLEEVFARESNKPLPSFLDEIFRYLEKESINTEGMFRVSAGKSSLEALQQKIESGAPLELSASIIDPHCVSSVLKLFLRSLPEPLVLYNVYSKYLTVAKNNNNNNNNNNNNISNSSSNLNIVGSSGNNNSGGGSGGTIITELRRLISTLPVCNQALLKQILLICSLMNQHRDVTKMDLTNLSVVIGPSILEPIPNLKAEDIQRPETFADFNSLFCLLVEHVLTIFPQVSQTSMDMASLPTTIGKLRSQSDISSQTKPLPSLPTSPQNRSAIITGDSSSPSLNTPPVKSSLNSSDFVIVDNGSNNNNNNNTTNTITNNGIADTATPPPPTTPTAPTTPPPPTTPTSNNIATPIININIPNSSNNNNNNNTKRINNKSNLKVDDYLTPIDMQIYYINISSNLGRIKSYVDDIETVNQGIGLIKLFKKISDDHMAPIKNILNYKFKTEKPPMSNDEDKVLRIKRTLFYTYEITMELISHANNTFESSSIEEPTELSKKLEESFKQLDTILTDELSNIEKQQQQQQQQTNDGGGSGISSNTNTSISGDNSENGDSLNSSTSNQSPLNSSILTQLSNQ
The following text describes a protein:
Function:
Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MGIPKSSIYFCILLFCIISFYLQSSKDGPKELKVKYVFLKKATAKQRGESSLTDSDYFPKQPNMNATLFMLCRNRDIKDALVSIQSVEDRFNHRYHYPWTFMNDAPFTKEFITATSKMVSGDATYVQLNNEEWGIPINIDLNRMLKSIRDMTDDKVIYGFSLSYRIMCRFNSGFFYRNKALSHYDYYWRVEPGVEYSCDIPYDPFRKLSDENKAYGFVISMTDYYETLPSLWNVTRDFIHQNPQYLAQNNSLDFIVNDHQGLSGDYNLCHFWSNFEIANLNFFRSPAYTDYFAHLDKNYGFFYERWGDAPVHSLAASLFLNKSQIHYFEDFGYYHLPWYHCPTDVQSHATARCLCDPTGTIDYLPFSCAIKWLENINS
The following text describes a protein:
Function:
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MALAYENLKLHITPEKFYVEACDPGVEDVLTIDRVSTEVTLSGKKDIPPSAITRAIYGILGTIRLVAGMYLIVITRRKKVGDLLNHSIWKATDFDIISYKKTMLHLTDSQLQDNKAFLGMLSHVLSVDGFYFSVSYDLTHTLQRLANTSPEFQEMSLLERADQRFVWNGNLLREFSAQPEIQKFAIPVVHGFIAIHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGNKASFVQTRGSIPFYWSQRPNLKYKPKPQISKAVNHMDGFQRHFDSQVISYGKQVVLNLVNQKGSEKPLEQEFSQMVSGLGNGMVRYIAFDFHKECSRMRWDRLQILVEQVAETQDEFGYFLVDTEGKVVSQQDGIFRSNCMDCLDRTNVVQSLLARRSLQYQLQRLGVLHVGQRIEEQIQFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQWGLLMDGWNSLIRYYKNNFSDGFRQDSIDLFLGNYSVEEAYSTSPLHIQTDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGTASIGTGAIIMYNGKDFVDAPKLVQKEKMD
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDPSAVSFDSGGARRGGGGGGAQMLLFGGGGSANSNGFFRGVPMAVLGMDDATRVGKRPFFTTHEELLEEEYYDEQAPEKKRRLTAEQVQLLERSFEEENKLEPERKTELARRLGMAPRQVAVWFQNRRARWKTKQLETDYDRLKAAYDALAADHQGLLADNDSLRAQVISLTDKLQRKETSPSATTAAQEVDQPDEHTAASGTEKLLVQQLKDDLHSSGDFTGHGALSSEEEDGGVVSDEGCSFDLPDAMFAAGVTHHGAEEAQLANWTSWFWN
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSWNLKGRAAIASLDPPTRYRVLHSHTMTRCANKPLLWVLEELITLRYLGGLTGPLHTANYFICLVVRLLQICPSVAIVRVMLEQDVHKYLRAAALLIIRLIGNVELQREAMRVGWSDYRKLCLYGSDPAQELAESTSTTAAGAEGVTAGTSRTLASSMLPLGHSKRSRAEMEMYRGNSNLASDAQSGESDPANAQVPEPPQYWLIRTDEFTDYLFGVASPSTASQGKDPHEPSKAPTSPPPTPSSVGASSRTLPGHTFMGLHFPAIIV
The following text describes a protein:
Function:
Catalyzes three successive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid, a key step in gibberellins (GAs) biosynthesis. GAs, which are involved many processes, including stem elongation, play a central role in plant development.
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein.
Sequence:
MDAILNLQGVPLGTALTVGGPVVALGGISFWLLKEYVNDQKRKSPNFLPPVPEVPGLPVIGNLLQMTEKKPHKTFTNWAETYGPIYSIKTGANTIVVLSSSELAKEAMVTRYSSISTRKLTNALRILTCDKSIVAISDYDEFHKTAKRHILTSVLGPTAQKRFRIHRDTLVENVSKQLHDLVRTDPNEAVNLRKSFQSELFGLALKQALGKDIEAIYVEGLDATLPREDLLNILVLDIMEGAIDVDWRDFFPYLKWVPNKSFEHRIQRKHLRREAVMKALIADQRKRIISGEELNSYIDYLLSEANTLTEKQILMLLWEAIIETSDTTLVSTEWAMYELAKDSKRQEQLFLEIQNVCGSNKITEEKLCQLPYLCAVFHETLRKYSPAPIVPLRYVHEDTQVGGYRIPKGTEIAINIYGCNRDKNVWESPEEWKPERFLNGKYDPMELQKTMAFGAGKRVCAGAQQAMTISCTAIARLIQEFEWSLKEGEEKNVATMGLTTHKLHPMLAHIKPRN
The following text describes a protein:
Function:
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSTETASGPTEDQVEILEYNFNKVNKHPDPTTLCLIAAEAGLSEEETQKWFKQRLAQWRRSEGLPSECRSVTD