lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSAANCSFDPITEKEWLCSPEQRCVNLTSGVNGSLIDLDNACLTEEEYLEKYLGPRRSSVFLPVFLSYLVIFLVGVVGNMLTCTVIARNKVMWTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPFLLGKGGCYFKTFLFETVCLASILNVTALSIERYIAVVHPLKAKYVVTRTHAKRVILTVWGVSVLCSVPNTSLHGISILHIPSTGPAGNRNEEIPDSAICTLVKPRWIYNLTIQLTTFLFFILPMLTISVLYMLIGLQLKREKMHQALEAKSGFGQESFCNIRTRQQKIRRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFINEWTDSHREIFEYVHIISGVFFYLSSAVNPILYNLMSTRFREMFKEVMCHRQHNITPRKNSLSVTRLTLRSTLSDAPLSNRTAAVETEGGDGELRKKDEITESKKY
The following text describes a protein:
Function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MSSQTSTGMATPVTYPPPEQASTGNTTVPYTFPQAKLKLQQTQPGRTPLVLVACGSFSPITFLHLRMFEMASDFVRFNTNFEVCGGYLSPVSDAYKKAGLAPGHHRVEMCSRAVEHSSWLMVDPFETVNCDENGEPAYVPTARVLRHFDHEINTVLGGIEGTDGVRRKAKIALLAGADLVMSMGEPGLWSPVDLGVILGEYGAFIIERSGTDIDEALATLRQYEDNIWVISQVIQNDISSTKVRLFLKKDLSVRYLIPDPVVEYIEEHGLFQDEQSSKKKNNDTSSTGGKDKEKEKPTTADGTSTPSSSTEETTQQS
The following text describes a protein:
Function:
Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Cytoplasm, perinuclear region. Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region.
Sequence:
MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG
The following text describes a protein:
Function:
Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor (By similarity). Has a role in meiosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSYKLEKEAFVSNLTGSSSIETCGLLLIGIACNVLWVNMTARNILPKGNLGFLVEFFIFCLIPLFVIYVSSKVGVFTLCIASFLPSFVLHVISPINWDVLRRKPGCCLTKKNENTFDRRIAGVTFYRSQMMLVTVTCILAVDFTLFPRRYAKVETWGTSLMDLGVGSFMFSSGTVAGRKNDIKKPNAFKNVLWNSFILLILGFARMFLTKSINYQEHVSEYGMHWNFFFTLGFMALGVFFFRRSLKKVSYFNLATFITLLHHCLLVLTPFQKWALSAPRTNILAQNREGIASLPGYIAIYFYGMYTGSVVLADRPLMYTRAESWKRFQRLLFPLCILLVLYLVSNFLSVGVSRRLANTPYVANVAFINMFFLTIYILIDAYLFPSSVPYGSRVPKLLEDANNNGLLVFLIANVLTGVVNLSFDTLHSSNAKGLTIMTMYLFIICYMAHWLAQHGIRFRL
The following text describes a protein:
Function:
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSLLLTVLKRVNLISLPRPSPHHCSVPRPLEASGLAWEGGRDSSVDDRRLVSGSSPDVLEKVRGQVEVSENFLTEAEERALLQELEPGLRKKRYEFDHWDDAIHGYRETERVQWTEGSWAVLRRVRQAAFPAGEPLLGPVHVLDLDRTGFIKPHIDSVKFCGSTIAGLSLLSDSVMRLVSEQDMADWVDLLLPRRSLYILRDSARYSFTHQVLRDEESFFAGRRVPRDRRISVICRNLPA
The following text describes a protein:
Function:
Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.
Subcellular Localization:
Peroxisome.
Sequence:
MSYNLANKIAIVTGGLTGIGLATTIKLLKQGSKVIVGDFLHEHEIDTVLNHIHKQVPENNRNIKFLRINIANYQDNVNLVDFALDEYSDLHYVVTNTAITTTTAIASNKTETIDQFKDVIDTNLNGVFALNKLAINYWEEFHKPGSIVNVSNILGLTTTKGLTSYRVCQGGVQSLTQSLALPYANKDIRLNSVIPGYVEISPMLGQINQHIATTAIKQHPMARLGNPDEIANAIAFLLSDEASFVNGTSLVVDGGYSAQMGN
The following text describes a protein:
Function:
Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MAGEEAGRNEEPFPLPFSCASTQPHPQLGNTQQQTELGKELTATMPHQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSSLAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTHKYSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGHAGAAASESLFISNHAY
The following text describes a protein:
Function:
Probable transcription factor that may function in the maintenance of the proper function of the central cell in pollen tube attraction.
Subcellular Localization:
Nucleus.
Sequence:
MASSSSSSLSFSTSKKNKTFFKKPNSAFSSSRATSLIKRQQTVFKKAKELSILCDIDVCVICYGSNGELKTWPEEREKVKAIARRYGELSETKRRKGSVDLHEFLEKMNKDDPEKEEKKKIKVRRVPKVKYPVWDPRFDNYSVEQLMGLVQSLERNLTRIQHRTCAVVEAQGQRRVQYTNMANQELMMANTMNQLQQHSNQVSMYLWNHGNGAFSQIPVSALASNQTQSLAPIPPELMIYPNSDAGNYSGSLGVQGTGINGLQNMNMLTYNNINSVNDFSKQFDQNSRAESYSSLLGVHEDGNNEFENPNMSSRNNFNVQDCAGLLGMQGAGTNGLQSMNMHDYSNNNSINSNGLSHQYVQFPTYNSQHQDRVFNLDQNGNNTRSL
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKKPTNKLLFDTPGWTIPKENINSEKKAKRKKNRNKPTTERPSSSEQQQEDSPSPKRLKNSHPHNNKQQQQQQPTKNQPNETLHVGTHQLAKGLLNSNLNGSRFRILNETLYTSTGPEALKLFQSNPIEAAADDEEEEGGGEHRIRREENPNFEIYHLGFRSQTKHWPQNPVDLIAHQLQQDPHLQKIPGPVLVADLGCGEAPLAKLLCSSPSTSSSNQKNSKPIAHHNQFKVFSYDLVADREGWITVAECSSLVPLPGSLDDRVGNGMMDIVVCCLSLMSTNWVGMILEARRILKHDGELRIAEVTSRFVDVDLFVTFIKSIGFSNPTKDQSNTHFILFKFKKLPLTLAKNQRDSSSVDLLNPQSKLELIQTGQKLLKPCIYKRR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSEEIAFEDRNSNGIAMDNIINVADCCRACLRIDCSLTPTSAQDNDSIKFCDKLLSCVSEVMWQKEGLPSLICSTCIERLRVAYDFRNICLQSDNTLHRYITHLQEDSKNLGVRTLTTPTKFDFTITTSTQDEIPISVEEPQNAEYLHLKHFLDNDEDLTKNETLVEVAGSESTSPDSSTATFLANQEQPPQQPPQIIQIQVQPRQVIKRTTGIQVRPPTPDQDGVDVKPFTCTICGKNYRKNANLRIHMRTHTGEKPFECKYCEKRFYHSSHLREHIRRHTGEKPFQCAVCNKRFTIKGELTMHMKSHTGEKPYACTCCDRRCLTAADLKVHMRTHTGEKPFSCVTCGKKFASTYILNSHIKTHTGERPYTCSICGKSFTQSSHLNVHMRKHTGEKVSCKVCDAKFTHSSQLTVHMREHTGKQPYKCTMCDKICNYASELQTHMMKHTGEKFTCVTCDKKFTTAAYLQEHTRTHTGENLSTCPVCDRQFTRHQYLQKHMRTHTGEKPYTCFTCGKRFTQSSSLKVHIRIHTGEKPYSCTICDRRFTTSSDLSAHNKKHKKYINL
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MAIIIPESSYERRVKALYEKQIRMEALEGKFIKKVYKFNSNLLDVKEAVLRHQRKVGKLQKVVMERREELEKRVSFMEELAQELEATKLRNLAMKEQIKQRKMIARQRKNEIMERIQTLSKTTGTYVNQEALPARVKGVTVLRGDKRDQLIPFDLNATDAEGLNSLCQHLESLNVDVSQWQQLVSLAMDVAMEARAPTTPPKEVANCKSIIEIDLTSPTSHQA
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MITFTDSMKEPVKETEKCLDSQLWHACAGGMVQMPPVNSKVFYFPQGQSEHAHGNVDFGNSQRIPALILCRVAAVKYMADPETDEVYAKIRLVPLRNNEPEYDDDGVLGSNGSEVPEKPASFAKTLTQSDANNGGGFSVPRYCAETIFPRLDYSADPPVQTVIAKDVHGEVWKFRHIYRGTPRRHLLTTGWSTFVNQKKLIAGDSIVFLRAENGELCVGIRRAKRGVGGGPESPSGWNPAAGNCVSPYGGFSVFLREDENKLMRNPNGGNSNSGGGLRARGRVRPESVTEAATLAANGQPFEVVYYPRASTPEFVVKASAVRAAMRIQWCSGMRFKMAFETEDSSRISWFMGTISSVQVADPIHWPNSPWRLLQVTWDEPDLLQNVKRVSPWLVELVSNMPAIHLSPFSPPRKKLRLPQHPDFPLDGQFPIPPFSGNPLGPSSGPMCCLSDSTPAGIQGARHAQFGISLSDLHLNKLQSGLFPASFQRLDNNTTPPSRIPNSLSLVKGNPNSTENISCLLTMGSSTQSSKKSDSAKSPQFLLFGQPILTEQQISLSCSGDMVSPVLTGNSSSDGNLDKTANFSDGSASALNQQGLADNSCQGFPWYKDRPTTDLSLETGHCKVFMESEDVGRTLDLSVLGSYEELYRRLANMFGIERSEMLSHVFYRDASGAVKHTGDEPFSEFMKTARRLTILMDSGSDNLGRAWITGLQNAENGLNASNKTGPLSIFA
The following text describes a protein:
Function:
GPI-anchored cell wall protein required for mating efficiency, biofilm formation, and virulence. Involved in normal disseminated infection, but not in intestinal colonization.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRFATAQLAALAYYILSTEATFPLLGDIFNCIPHNTPPVCTDLGLYHDSSISLGGSKNKREAEIANKDGTIEKRTFGSAGVNAGFNAAFVVSNAKKLSDGSYGIDCNFKSDSSVQLNSAFGKKVKQLSITGTGYSDISLLGNVANPFEWSASLKVKAEIVKGKCCLPSGFRIVTDFESNCPEFDAIKQFFGSSQIIYKVNAVSNAIGTFDASALFNAQVKAFPAKRELDEFEELSNDGVTHSKRTLGLLLGLLKKVTGGCDTLQQFCWDCQCDTPSPSTTTVSTSSAPSTSPESSAPSTTTVTTSSSPVTSPESSVPETTTVTTSSVPETTPESSAPETTTVTTSSVPSTTPESSAPETTPESSAPESSVPESSAPETTPESSAPESSVPESSAPETETETTPTAHLTTTTAQTTTVITVTSCSNNACSKTEVTTGVVVVTSEDTIYTTFCPLTETTPVPSSVDSTSVTSAPETTPESTAPESSAPESSAPESSAPVTETPTGPVSTVTEQSKTIVTITSCSNNACSESKVTTGVVVVTSEDTVYTTFCPLTETTPATESASESSAPATESVPATESAPVAPESSAPGTETAPATESAPATESSPVAPGTETTPATPGAESTPVTPVAPESSAPAVESSPVAPGVETTPVAPVAPSTTAKTSALVSTTEGTIPTTLESVPAIQPSANSSYTIASVSSFEGAGNNMRLTYGAAIIGLAAFLI
The following text describes a protein:
Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). Involved in the regulation of filamentous growth.
Sequence:
MSELHKAFLRRIKEQETALGLSGLVDEDDIPEPAVMPPTGNSSSTANTEDETILRDYKQFKETNFIQEFYENELGHKFKTYYKPSKKPGSILFCHHGAGSSSMTFGNLVNHIEDESVGIFLFDTRGHGESVATSDFSLDTLVQDVSFVLEQFSSKHQQTSIFLLGHSLGGAVLAKYSTLYPSDILKGLILLDIVEEAAVQSLNAMPSFIARRPLSFPSLSKAISWHMNFLLFNEKSARLSVPDLFTDKLTWITDLNATQPYWQTWFSGLSENFLGFKGPKLLMLSTHESLDKQLMIGQMQGKYQLVVFKNNEKSGHFVHEDLPNHVAVCLTDYIKRAVAPEIFMKEDLGVVPKWGGKINK
The following text describes a protein:
Function:
Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination. Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51. Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation. Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair. WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2. Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination. Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination. May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo.
Subcellular Localization:
Chromosome. Nucleus. Chromosome, telomere. Note=Colocalizes with RAD51 to multiple nuclear foci (By similarity). Colocalizes with DMC1 on meiotic chromatin (By similarity).
Sequence:
MVRPVRHKKPVNYSQFDHSDSDDDFVSATVPLNKKSRTAPKELKQDKPKPNLNNLRKEEIPVQEKTPKKRLPEGTFSIPASAVPCTKMALDDKLYQRDLEVALALSVKELPTVTTNVQNSQDKSIEKHGSSKIETMNKSPHISNCSVASDYLDLDKITVEDDVGGVQGKRKAASKAAAQQRKILLEGSDGDSANDTEPDFAPGEDSEDDSDFCESEDNDEDFSMRKSKVKEIKKKEVKVKSPVEKKEKKSKSKCNALVTSVDSAPAAVKSESQSLPKKVSLSSDTTRKPLEIRSPSAESKKPKWVPPAASGGSRSSSSPLVVVSVKSPNQSLRLGLSRLARVKPLHPNATST
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQALPTILPPPPLPDDSEAPARTPEKHANLVRFQSELEFIQCLAHPQYLHELHIQGYLGKPAFLNYLKYLEYWREPQYVRFIIYPTCLVYLTLLQTELFRSRLGDMGFITELMRVGSRHHATWRVGKPAEDKQSEEKPAVSMAPLDDDEEEDEPERGQETKGKRKKKKSRSGNVGAGQAL
The following text describes a protein:
Function:
Probable ligand of isoforms a and b of the calcitonin receptor-like protein, pdfr-1, a G-protein coupled receptor. May not signal through isoform c of pdfr-1. Involved in locomotion; more specifically mate searching behavior of males, independent of nutritional status. Involved in regulating the male-specific expression of TGFbeta-like daf-7 in the ASJ chemosensory neurons. Plays a role in circadian rhythms of locomotor activity. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide flp-2. In the presence of food, plays a role in initiating and extending exploratory roaming behavior, in opposition to 5-hydroxytryptamine (serotonin) signaling.
Subcellular Localization:
Secreted.
Sequence:
MNRFIISMIALLAVFCAVSTASPLLYRAPQYQMYDDVQFVKRSNAELINGLIGMDLGKLSAVGKRSNAELINGLLSMNLNKLSGAGRR
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAKEKATKLEEEELQPKEQPEKPKKKTKFPLLIIIAAIVLIVGAGGAYFFLTGKGAEHGKGSATKDSKEVQGINFALEPFVVNLMDQSGTKYLKVSVQIELSDAKLAEQAKNKTPQIRDAIITLLTNKTSDELITPEGKLLLKDEIKQRANQILGEGTVINVYLTDFVMQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MPGGPATAGLSAAVGQWTKFLARAEAKRLDPSDFARFVPILNSDFYPLPPIVIANLLLRPTKQSSYSLDPRRLQYLTILLNQKLVNPQSVLKVLHHYSTSQAKIQSEHDAGTTNEAATATKGGQGQQGDKKPKRVFWQNSYNDEEVIFLRLSKVITHGQGIRHASDAYEMATNLSKWTTLFIDVIAAFSRDTFGTIQNMRTKQDMETSLQAFSLLLVNFLGNQRVVSAFSRPEAKSHRKRLASSIDQLIPYLLQNPNTSGIAERLEFSRGQALAGEESSDLKDAAVAEMHSYMDNMIGLDTWQIPDMPIVNSRAGLYIYINAALVGRPLIDDHSLYTYLHNRYQGDLQTTAIHLILASFDVLANAVFREGSKTGHLLKSYVVNKVPLILGNFAASSTHMYPFDAEFCISQALGQVDTNVFPTLSNMFDMSNTSSSFQDSVRQDFCFACQLHGLLSASAIETLLGEITYQTLPDEGRYVKETLVQACLEDFERSQRLIGELDNMNGNVGAAAQAIVEVIGTLCRNKETMTLKQLCSQLASKPSSLDILLLFDKPYKILHPLCELLDDWGGYDEDQGEYQPVYEEFGSILLLLLAFVHRYSLTPTDLAIRSPHSFVGKLLGRGQLSRPLDELSDQEKSHLNGWVHGLFDSEAGGLGDDLMSSCPPQDFYLLMPTLFDQIVMALSTGCLNDYLLRSGLEYLLDTLLLPSLVPALLFLANNLRTDKQPGQGAVIKILQLILRPNSISNEASTMLSSVLNIVAKPLELSLRSYQRQVPASQEVEPLLRALKENLAVSSRTGGADHSELENWTGTHHNGSGSVGGLYGAIRHTVQNLVQWAQHSPGNGVPATYTHRQVLVALQICGAKRLLSALLKELKTQTEAGNGSVAYDVVTAIICAPDVHNTPVTDDNDPSSARGGGDAANHTITKKQRRITLREALKFEAEEFKKIQKSDPLMAETVVRLHRRVEAQMALPPPPPPPAQHHHHHHQQTMLQPELSALGVVAGDAMGDSMMNAAAVQVSGSDHHHPMDAMSLDATGMGGLDVGGAGGIDISGMGDMGMGNMGMGNMGGLTVNTNTGGGMGGGVGTGGQGGGSAGGGGAGASAGNGGGGGGGAGGAGGGGSGSGGAGGDLSGDDIFSGLGTGDFTTDFGNWDTMDLG
The following text describes a protein:
Function:
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway.
Sequence:
MVRTRYEYSLRSKKIRIFDTTLRDGEQAPGIDLTTEQKIMIARKLADLGVDVIEAGFPASSEGEFIATRKIFEEIGDQVEVIGLSRSNKNDIDKTISTGISSIHLFIATSELHMKYKLKMTKEEVLNKIYESVKYAKDHGMIVEFSPEDATRTEEDFLFTAIRTAIEAGADRINIPDTVGTMHPFKYYDMIKKIVNFVGERIIVSVHCHNDFGLATANSLAGVYAGARQAHVTVNGIGERAGNASLEEVVMGIKKLLNYETNVKTWKLYEVSRFVAEMTGVPVPYFKAIVGDNAFGHESGIHVHGVIENPFTYEPISPEEVGNFRRLALGKHSGIHGLRKLLEEQGIYLSDDKLKIVLAEIKKLAESGNKVTVEDAKNIALKLMNS
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MNISSMLSSDNNVSLKESMTTATDQQQQQQAESVDHASINGNGQTSVSAVNNVQENHLSEFHSSNQQHSSIPPVGTTVEHATTTTTTATNHQPVNSSPLKHSVDENSNPTTISSLKKDTNSIIASILPESYQFDNSYTPTIDQKYKSVFESNINVINQLDQYQQMGHHLKLMKFDEVKLNNYLINTGQFASNYIDRVVAEDISSRNNKISETNKNKELIAIDYSKPLHHNSTRGKEFKWGSTRKIHKVEHKSRRRKPAATTSTTDDSNKAVAAAANGTKDHSATAGTTASANGSDTPDRRHQRQSSKPSTPILIKPKTEPGKGSPEIQPRRSSRPKVKRKAFEDELETADKQSSTQQVKKSQESTGRDHKRVKIENKQEEQQQHQQQQQADEEDEAEAEAEAEQKPKSGALSEAAAAGMTAKEFKAFMRQYDNTYIAIWKDLSRKDGPKGSRSMQQATQGRLINLRKTALLAAREAKRWQLKNTKNQKDLTTKARRAMREMFNFWKRNERLERDLKKKHEKELLDKAKKEEEEREAKRQSRKLNFLITQTELYSHFIGKKIKTDELEGTNADDNLKSNTKEHLDKYADVDGSATHDINAVDFDNDDEEALRRMAAQNAQNALIEVQNKAKQFDNSEESFKNPDTNGEEMNFQNPTLLGDITIPQPNMLKCTLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISVLAYLAETYNMWGPFLVVTPASTLHNWQQEITKFVPEFKVLPYWGNAKDRKILRKFWDRKSLRYDKDSPFHVLVTSYQLIVADIAYFQKMKWQYMILDEAQAIKSSSSSRWKSLLNLTCRNRLLLTGTPIQNSMQELWALLHFIMPSIFDSHDEFSDWFAKDIESHAQSNTSLDEQQLRRLHMILKPFMLRRIKKNVQSELGDKVEIDVYCDLTTRQKKLYQQLRSQISMSDTDLLELESNSTSSDSSLANLVMQFRKVCNHPDLFERADVNSPFSFGKFAETGSFLRETNELDVNYSTENIVQYDLPRLIYDELLTPNYNKSIRDSIYSKFSIYNPENMNATGWLQGINVSPNELKHYSQMDILSRAIEMQNKPTETEKLERINYLYEGDYIPKNKKLLITDHSTSTNSSFISNSLVFSDLVSIKEKVGEDMYLNKLEPAVTPIASAPPITVNCSSMNFTNKMNNTLFDSNIRSSLIPLSLSTELKLMKDQIPLEQYPKSNMLPMPIFDYSNIRMPSMDRFIAESGKLAKLDELLIDLKRGGHRILIYFQMTRMMQIFEEYLAYKSYKYIRLDGSTTIESRREMVQAWQTNPEIFIFMLSTRAGGLGLNLTSADTVIFYDSDWNPTIDSQAMDRAHRIGQTKQVKVFRLVTRNTIEQKILERAKEKEEIQKLVVGNM
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRRSGRTPVGGVRFAADAEQDDSGAIAITLGDAAAVGAPLEQLLAAAAGVGGSNGTPGAAPGNAPRVSPSRGATPLPAEIDEREGGGDGRRRGGSGTGVGLHMGGLQLLHDTQQDEMSHDEGGYGGHSRGDSDADGPLDGAGGGISVGGGLDHVDVDGVRTSARRQPMGDGFHSGDEERGPDAAVLATGGSHGGGGGGVSGGGAGGGPGGGGGGGAGRRHHRALSGKPGKSGKSGKQSVMRTWLRIERNGETSLLQADKWRITHKLGIQTRDLRLLDPNLSTTYPSAILCRDKAIVVNLEHLKAIITTSFVLVVNPEDEKVVRFINELKGRLSTATAGGMPQSRSFQALTDAERLKLAPGPSTLGVDLPFELKALEVCLDVMAGHLDFLTQELEASAYPALDSLANKVSSPHLERVRRIKNNLVRLTTRVETVREVLEKFLDDDSDMHEMNLTAKELHEIEERRQLEQENNVDAHSTVSTTGSRSSGSSSSASSDSSVEEAETAVVEMLLETYFMHVDNTYNKLQTLHEYIGDTEDLVNIKLDQHRNQLITIDLILTAFTTVLAMMTVVGAWFGMNLDSGLQQAPGLFTQVALGSSIIGVGLLMLFVFWLWRAKLIIY
The following text describes a protein:
Function:
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Sequence:
MLRLLALLLHCLALASGDYDICKSWVTTDEGPTWEFYACQPKVMRLKDYVKVKVEPSGITCGDPPERFCSHENPYLCSNECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRYPSPLEANITLSWNKSVELTDDVVVTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMPARRARDLSASGAHRVLCTEEYSRWAGSKKEKHVRFEVRDRFAIFAGPDLRNMDNLYTRLESAKGLKEFFTLTDLRMRLLRPALGGTYVQRENLYKYFYAISNIEVTGRCKCNLHANLCSVREGSLQCECEHNTTGPDCGKCKRSFRTRSWRAGSYLPLPHGSPNACAAAGSAVGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVCDDDQLLCQNGGTCVQNQRCACPRGYTGARCEQPRCDPADDEGGLDCDRAPGAAPRPATLLGCLLLLGLAARLDC
The following text describes a protein:
Function:
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step. The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA. The roles of dbaB, C, E and F have still to be determined (Probable).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MPGTVRPGEPVQVAIIGGGIVGVVLAVGLIRQNVKVRLFEQSQGFREIGAGIAFTANAIRCMEQIDPAIVTALRSSGSVPTSTGDEKDPNDYLRWIDGYNLHREDDPYYQRMLYKINAGYRGFEGCRRDQFLEALVKVIPPEVVECKKRLESIEERGLEEKLILTFVDGTTVEVDAVIGCDGIKSRVREIILGEGNPASYPHYTHKVAYRTLIPMEDAIKALGEYKAKNQHNHVGPNAHLIHYPVANKKMINATAFVSDPNEWPNDRQMVAPGCREDMEKAFAGWSPCVRNVVNLFPKELDKWAVFDLWDYPAPFYNKGKICLAGDAAHASSPHHGAGACIGIEDALCLATLMKQVNVSVQASRVSKGKALSAAFETFNAIRRTRSQWLVNSSRRVCDFYHQPEWADPAKWVKAETCFEELKDRSYKIWHFDYDEMIKETLKSYSNREAALLQESSEGSVEK
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAMTPVRPAFRKISLLRCPSVRRSHSTSTSSVSASEVSHFSSLASSWWDPMGPSRVLHLMNPIRHEFIASCLAESSPDSLTKQPGTPPNTLHYLDVGCGGGIFAESLARTIPIPGSTESKSGTVTRAASITAIDPTTTLIQIARDHARKDPKVLAHLNEGRFQYVNCTLEDVIASSPNANQSSNSTDASRAGAGVRRKDGFDVITLFEVIEHIDTNASITPLTFLTNCLRLLKPGGWLIGSTIARTFPSWLVNQVIAEAPWPVGVVPKGTHEWKKFVNPDELESWASEGLMRSVDLERNSVARSGSEALDGMRWKCAGVVYFPGLGWKFVPGSESWGNYFWAIRRGV