lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain. Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction. The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region; The zinc binding sites in the N-terminal domain are important for tetramerization and assembly of a functional channel complex (By similarity). Most likely, the channel undergoes closed-state inactivation, where a subtle conformation change would render the protein less sensitive to activation (By similarity).
Sequence:
MAAGVATWLPFARAAAVGWLPLAQQPLPPAPEVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDAESGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGEGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGTPRWPSKEQSCGDRFPTAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLFVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGDGQMLCVRSRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSLGGRTSRSTSVSSQPMGPGSLFSSCCSRRVNRRAIRLANSTASVSRGSMQELDTLAGLRRSPAPQTRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPSGGGGSGGTPNTTLRNSSLGTPCLLPETVKISSL
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Single-pass type I membrane protein.
Sequence:
MRRHLFLFFHFGADQKNTMSIILLWSQKQHTVLLHLCYKMFRLLDLALVLFVTLQILSTGDCWKVSEKQRHKREWVIPSKKITENVDYSKTPIIGKIRSDMDDKVALRYTLRGPGINERPVGCFMVEEYKGLVRIIQPLDREERNNYTLIGTAWYVVNGSIAEDNIQISVTVEDQNDNPPVFIKAEGSSIYEGSPAGTFVTKVEATDADEPNTLHTKIAFSIIKQEPNNNNHFFTIDKDRGIISLKNPALDREENSLYVLTVQAADMYGDATGNSATVTIPIDILDVNDNIPTLEKDEFSVSIDENEAPIEVLRIQALDIDEVQTDNWLAEFTIVTGNEDGHFSIKTDPRTNMGVLYLNKPVDYESASNLDLSLVVANRAPPGAPLGNGVGAGSAAGASGAGGQSGVGGQSGSFGAGGQSGSSGTGGQAGATGAGGQSGSSGASGQSGASGAGSQLMPFGGSSNPGFNVSKLKSYLVKVNVKNKPDAPKFMPKVKPISISENKKNSIPRVIDTYTATEEDTGRPAENVKYAKGYDPDNWISIDVDTAEIKLNKVPDRESPFVVNGTYYAKILCITDELSAKTSTGTIALQVEDLNDNCPILLNNMQIVCSHTKVVNVTAEDIDSDPNGTPLEFSLIQEKTRGKWNLQRINDVSASLLAEDDLWPGFYQITMEIRDKQGLACPTEQVLNLEVCTCSEGVGCGSKIGEVHTSSSANFGLPGIGFLVLGFLSLILMLLFLIKCECGSTGNKFIDLPFESKQHLISYSTETREEHRGVPLMWPPPNLDNKGGCEMSNGHLRMVSAMNSKIPVDTMGALSSNQAVYTSSKMDGIVQESEFGGYYYDTDDVEQTGSRFQELEVSQNAILQDYLMQKSRYISLDDSPGEAITSYDYEGNGSIAGSIGSCSYSESSDDIEFLNNLDSKFRTLAEVCGYRWTQSLSQADSKVIVNDTEKKPTTTELTTVSSSQLTNIIQSNSLDKTFKSPIAQTEPCQRMVIQEPMYYGFNQPVPSNVMRSDDGLGQGVYIINSTPEAEVLMIQSNSHTLAPLANDQQGFLANNITGDSVVYSQIGPQSSVMISEGLEDYPAVIPNLSPTSNLVMMQPQQLNGTGSLQMLRVPVGSVVQGEEENIGESYRPLNPQPFYPVRSLSGPTLINQTEADQSFSCVQNNRHIPGHPDIVNMPQIASGMVASGMVNNQVLVNIPVSSAPNIISLENGQSRHFEGHVSGHNLFVAGPGQYPVSMSMGMPNFVSMPQVATGQVNNSQVLVNALGSNILSREGGECRLANGPSFVEGPASGGNLWVSGPGQYPVSLGAGTPNLVSVAQVANEQVNNNQLLVSGPTSSVINIASGKGGQSRPLFSSPSTLEGSSQGPLVISPRALSPVGLPQVASRPLFRSTASRVMAAVAMAPKSKECVTNGHLHI
The following text describes a protein:
Function:
Regulates autophagy. Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PtdIns3P), thereby regulating membrane trafficking. In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3-phosphate in early endosomes to allow for the conversion to late endosomes. Involved in the clearance of engulfed apoptotic cell corpses. Together with ced-9, negatively regulates somatic and germline apoptosis. Plays a role in endosome-to-Golgi retrograde transport of mig-14. In a daf-18/PTEN- and skn-1/Nrf-dependent manner, promotes germline stem cell proliferation during late and adult stages, probably by ensuring cell survival and cell cycle progression. Required for embryonic development and L3/L4 molting during larval development. Required for normal dauer morphogenesis and lifespan. Plays a role in male tail ray pattern formation. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.
Subcellular Localization:
Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. Endosome. Note=Co-localizes with rme-8, a component of the retromer complex, on endosomes.
Sequence:
MTTQRSHICLNCQHPLRLDFTQRRPDSADSEKKSETVITEALTGHSRNLMKLISDAQFPSDAPVCNDCSDALRNEMDAQVATLDDEIKTYQTYINYLKENHPTTSIPDLKAKLQNVSDEEKELEQQLKKLLAEEEQLDLDLQTKRRTAEAASEKSGELWKKYRDNLRQVFEDQDELHSLEAERQYAEVQHRKLTDTNVLDLCFHIWVDGIVGEINGFRLGYLKDAPVEFTEINAALGQIVLLLEILLERIGVQHHELMPVAMGSHSYIKLRRNGIDMETYALYGQGTPLSGSSGIDPGIRRFLQLLEFLLKELKDRNKNFKPPYQIHADSLVDNGVKYNAVMTLNTDVRWTRAMALMLTDLKAACAQCDALRSPI
The following text describes a protein:
Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCSAGTDMGKELAKDTKSKTQMKKVNPNIDRGWAWMVVLSSFLVHLLVMGSQMALGILNLEWLEEFKQSRGLTAWISSLSMGITLIVGPIIGLFINTCGCRKTAMIGGFLTSLGWVLSAYAPNVHFLFFSFGVTAGIGSGMVYLPAVVTVGHYFQKRRALAQGLSTTGTGFGTFLITVLLKYLCRELGWRNAMIIQGAVTLNLCVCGALMRPLDHDEEHLKDHEEAAVDPKDAKEGALLNVNAIKANSELHEEEEGKASADTAVSWSKEETRNDIFINDMNKLSIMKTLTHMTVSVRSGFFAWYSSYFGASSLFTNKVFVAFVFWALLAYCSFVIPFIHLPEIVEMYGLTEQNNIFPLTSIIAIVHIFGKVILGFLGDLPCVSAWNVFIASNFTLGVSILILPLMHVYSSLALVCALIGFSSGYFSLMPVVTEDLVGIKQLANAYGIIICANGISALLGPPFAGWIYDITQKYDYSFYVCGLLYMVGIICLLLEPCLQSKDQPSKKLSGSQEA
The following text describes a protein:
Function:
Required for the maintenance of cell shape during interphase. Required for localization of cortical actin to the growing tips before mitosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEEFENDFPYKVMLNQQQDPSDAQSSPTFVPSANPSLTTPWLQTTPSANRPTWLPLQQHMHQLRHTGLLPAVESSFVHGHRRSASAGVGMGNFSNQATIPSNSPAVSNMQPPTQGGQPLYPTNFFTTSVSASSDSFPNSPTVPSKFSLNPSVATSTNISPRRHAKSHSVASVSSPNSHNAVPFTPHAFVPPVNNASPLPALNTLPQLLRPRNLDAQWRPSSLSQTNSPTHAANPSFPGTIVTHNTSNFRPEGGGHRHRRSTGSLSVGSSGSGFSSGGSGNPRKNLFSPYLPQSSIPALLAERRLVTGILIVSKKNRSDAFVSVDGLDAEVFICGSKDRNRALEGDVVAIELLDVDEVWAGKLEKEENRRRKDPISTRGSFDNLRIDAVPFEVPQRSAIKARDDEQVEGQTLFLLDQKQLGADEKPKYAGHVVAVLQRAPGQVFSGTLGILRPSSAANKERQTSSGNQGSSNNSGNDKPKIVWFKPSDKRVPLIAIPTEQAPTDFLGNDQAYAQRLFLASIKRWPVTSLHPFGMLVGELGSMDSMSAQVSALLHDTGVHSEPWEGSAATSAVTALNALSDNFLNVAGCADYRSEDVFLFVKNDVSKAAVSEVKQHESNINSSSATDFVSSAFHIRPTSTGYHVGIHVTDVSRVIEPGSPLDRELQRRSIAVNLCQKSVPLFPTTLGEALSLREDKDCYTMSLLLDVSSTGKIRGTWIGWAVIRPRKAYTMKEADELLQTDARLRLFHTVSSRLRTHHLGTDVPLSRYCRLVRRWDEESCSFDPNETNLFISSAVEVLRETLLDAANRAVASHLRQEFRENAFLRTQRLPSRENCRILQSMAIQMGCVLDLSSTKSLLRSLSLIEDDTVRNILQLYYYKVTPRAVYEMQKYKGNLASQMMSLGIEDESDDLTHFTAPLERYGDIVVHYQLQLLLRGELASEKRLRVWSQAANDASRRLVISKFAQETSIHIKIFSDWAESQVWQDGLVCFVAPSYFDVFFPSLGMEKRVHLDLLNLTHVRFEEDQGILSLYDESGAVTVVKLLTSVKVKLFVQLSTPPLINVSNVEF
The following text describes a protein:
Function:
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTAAVPAGATGRAKKVVVFDYGFGNVRSAERALARAGADVEITRDYDKAMNADGLLVPGVGAFAACMEGLKAARGDWIVDRRLSGGRPVMGICVGMQILFSRGIEHDVEAEGLDEWPGTVGPLEADVVPHMGWNTVEAPADSQLFAGLDADARFYFVHSYAVHEWTQESHNPLIAEPRVTWSTHGKPFVAAVENGALWATQFHPEKSGDAGAQLLTNWIETL
The following text describes a protein:
Function:
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MSHKENMSTKSYGGTRNQQKSNQRCEKRNTRWKTVKYLRIQCRNKRSRLKHQTSTTIKESAAVRAAVREGLRVAQSLGPTLLFVKVNQGKEETRRFYACSACRDRKDCNFFQWEDEKLSGARLAAREAHNRKCQPPLSRTQCAERYLKFIELPLSQRKFCQRCQQLLLPDDWEKHHEHRVVGDISITQLRRPSQLLYPLENKKTNAQYLFADRSCQFLVDLLPTLGFTRVLCVGTPRLHELIRLKASDDKKSNIKSLLLDIDFRYSQFYMEDSFCHYNMFNHHFFDGKAALEVCRTFLQEDKGEGVIMVTDPPFGGLVEPLAVTFKKLIAMWKEGQSEDSSHKELPIFWIFPYFFESRIRQFFPSFCMLDYQVDYDNHALYKHGKTGRKQSPVRIFTNIPPNKIILPSEEGYRFCPLCQRYISLENQHCEHCNSCTSKDGRKWNHCFFCKKCVKPSWIHCSICGHCALPDHSCGGPKDGCFICGELDHKRSTCPKITTSKKVNRAVRKQKQRKSNKMKMGITKGQSMNHTSVTRKKNRRERAHQYLCS
The following text describes a protein:
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Subcellular Localization:
Nucleus.
Sequence:
MPKRKAEGNAKGNKAKVKDEPQRRSARLSAKPAPPKPEPKPRKAPAKKVPKGKKGKADASKDANNPAESGDADTDQAQEAESAGDAK
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MEDEREEPPPAGSAAANASSTSGGGGGGGSKGSPCEECGEQPWKYRCPGCVRLTCSLPCVQAHKRRTACTGKRPRTDPVPLTRFDDNQLISDYNFLEEVKQAHESAHRLVGGFGGNFGGRGSGGAKLPGWLLYLSKAAKRRGVSLCFLPRGMARREQNRSRHNYRKDCIYWTLEWRFNSTDVVLTDHEVDEHTTLLSLLEKHLSPGPWKDQLTQYRNTDLHDLKLFIQKCAKRSESPYRLLNIEEPLRPQLRGILVVEYPTINVFLPSDNYDFEIEKMVNSLHKDGKNPGSRTDEPPVEGSEFHEEEIEEGEFSPETEIIDLKDCGASNACKISQADVTSESKIVNNVDSFVLSYLGCQALHGQPKELNQYSKMSPNGTSGPAETKSRMEVCPLGMEKTRKSRLSSEGHIVDLKGHGTSYPGSIAESEGAAVSKIDIKITDSLVASSISIVATDGVMGPQLEHSQQNKRTPSSTPEALKRKSCMKVYPLDFDERLFPEVPDLAFEQEMMDTYPDLFENMDVDDFLSCDFAMMNRVEPVEATTGLLWDDLEEGEIPTL
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system AlsBAC for D-allose; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MGFTTRVKSEASEKKPFNFALFWDKYGTFFILAIIVAIFGSLSPEYFLTTNNITQIFVQSSVTVLIGMGEFFAILVAGIDLSVGAILALSGMVTAKLMLAGVDPFLAAMIGGVLVGGALGAINGCLVNWTGLHPFIITLGTNAIFRGITLVISDANSVYGFSFDFVNFFAASVIGIPVPVIFSLIVALILWFLTTRMRLGRNIYALGGNKNSAFYSGIDVKFHILVVFIISGVCAGLAGVVSTARLGAAEPLAGMGFETYAIASAIIGGTSFFGGKGRIFSVVIGGLIIGTINNGLNILQVQTYYQLVVMGGLIIAAVALDRLISK
The following text describes a protein:
Function:
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Sequence:
ARLKIKMEAINGNRGYYNMEDRDLKHGKHLQCQDERLDSGLDSLKEEEYQEILQDMENLRVNPTEANRNDFHNDPWKLQRTEDGDTLLHLAVIHEAADCALQIIERCRGDPFLNVQNNQRQTALHLAVIMEQPQVVERLLTAGCDPRLTDDCGNTALHIACKKGSLHCFSVLTQGSTQHLPYIFNTTNYNGHYCLHLASIHGYLSLVENLIQLGADINVQEQCNGRTALHLAVDLQNLPLVQLLVAKGADVNSLTYGGHTPYHLTYGRQNAEIQRHLYALTAQDLRELPESEAEESDDEPLYEEDDMYDDIQLVRQ
The following text describes a protein:
Function:
Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia.
Sequence:
MLLLLLLLPLCWAVEVKRPRGVSLTNHHFYDESKPFTCLDGSATILFDQVNDDYCDCKDGSDEPGTAACPNGSFHCSNTGYKPLYISSRWVNDGVCDCCDGTDEYNSGIVCENTCKEKGRKERETLQQMAEVTREGFRLKKILIEDWKKAREEKQEKLTELQAGKKSLEDQVEMLRMVKEEAEKPEKEAKDQHQKRWEEQQAASKAQREQELAASAFQELDDDKDGAVSVTELQTHPELDTDGDGVLSEGEAQALLGGDVHADATAFSDRLWAAIRDKYRSEVLPTSPPPAPSEPDLTEPKEEQPPVPSPPVEEEEEEEEEEEPEEEEEEEEEEDSQVPREQPKEAPPPLVPPQPAASPTEEDKMPPYDEQTQAFIDAAQEARNKFEEAERSLRDMEESIRNLEQEISFDFGPNGEFAYLYSQCYELTTNEYIYRLCPFKLVSQKPKLGGSPTSLGTWGSWAGPEHDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETVVTSTTEPSRCEYLMELMTPAACPEPPPELPTDGDHDEL
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence:
MASVVNTNTVNFLERKRLNCHDTDIADIWQRLQDLYIKRQYRLWHQLTLELNSFMNSSYFNSGDELLEIYQQFISDIELRLGVFDTSVRRGPRKAINKRPLHKRIRTFQVNKDVESIVLCKTAIGRIYLARNDLNSVKRVVDETAPLLDEMQGITSVHAQYYDLCSKCCKMQGDFSGYFADALRFLGCIDLKDMTLDEQKARARDLSFAALLADNLFNLGELLVHPILNSLRKTNDEWIIRMLLAFNKGDHESFENLKPYWKEQTELAQNEGSLRQKLALFGLVELTFHKPANNRVLSFKEISHFTKTPLGSVEMLVMKAFARGLLEGKINQVFERAEMIWVRPRVLDLSQLTELKEQISSWSDKVRKTVSNIEEKSPEVVA
The following text describes a protein:
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively. Localizes to mitotic spindle microtubules.
Sequence:
MADSSGRGAGKPATGPTNSSSAKKKDKRVQGGRVIESRYLQYEKKTTQKAPAGDGSQTRGKMSEGGRKSSLLQKSKADSSGVGKGDLQSTLLEGHGTAPPDLDLSAINDKSIVKKTPQLAKTISKKPESTSFSAPRKKSPDLSEAMEMMESQTLLLTLLSVKMENNLAEFERRAEKNLLIMCKEKEKLQKKAHELKRRLLLSQRKRELADVLDAQIEMLSPFEAVATRFKEQYRTFATALDTTRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRRSFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVPPSLSRSGRDLS
The following text describes a protein:
Function:
Probably acts as a viral splicing factor that regulates viral RNA splicing. Functions as a multifunctional regulator of the expression of viral lytic genes (By similarity). Early protein that promotes the accumulation and nuclear export of viral intronless RNA transcripts by interacting with mRNAs and cellular export proteins.
Miscellaneous:
MISCELLANEOUS: ORF50 and ORF57 are the earliest genes expressed in the lytic cycle.
Subcellular Localization:
Host cytoplasm. Host nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Domain:
Binds viral intronless RNAs; the RNA binding site overlaps partially with the binding site for host ALYREF or ALYREF2.
Sequence:
MEDIIEGGISSDDDFDSSDSSSDEEESDTSPQIMKSDVTMASPPSTPEPSPDVSASTSNLKRERQRSPITWEHQSPLSRVYRSPSPMRFGKRPRISSNSTSRSCKTSWADRVREAAAQRRPSRPFRKPYSHPRNGPLRNGPPRAPPLLKLFDISILPKSGEPKLFLPVPSLPCQEAEKTNDKYVLAMAQRAMHDVPISSKQLTANLLPVKFKPLLSIVRYTPNYYYWVSMRKETIASANLCTVAAFLDESLCWGQQYLKNDFIFSENGKDIILDTSSALLSQLVHKIKMLPFCHCLMQTTPQDHIVKQVCYLIASNNRILDAVRYLQTSVIKSPIVLLLAYAVCLPAAIICTKNETQLYSHCMRILKEYRPGDVMNILHESLTQHLNKCPSSTCAYTTRAIVGTKANTTGLFFLPTQ
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MVNSRGGTFTPSPAQTIVTGVSHSPHGSHHSTFSAGASPSTNSPIGASGVNKIVVAQVYLLLGTIKEDKDRTKWEQQAEQLRKLVDEHGMEVFSKYFSRLVVGNAPQIFPGINRPVLNSGNYQILVNEVHKVAHDVDQAGKIAESIETGNEDIFRDFDLSTFMDHFKLDALEKTILALAFKTGSRSDLKTKADAILSANYQGFVEALSQVNQGQEDLTPSFLATIVDRFIQGHPPNFDHQAQILLFRAINYRFRDHPEQDIPAPTEVLAALFLMSIITESNPLILCIQKVGSAFTSDEDACRNHIRNAGDINLDEAQVAAALLYTAISRTPTFSSQVLVNSLRKEVPPGFSWCQVVRHFDTPDLRISPQQFLAVYESIRPIALEDPTVIPQLLGGAWQNTETQLSFISAYASLSPNELDASTIPKLRPSFTLEDYVDAKPEIRERAEWAIRHPLVSVITLTSVFIVALREPHCSETVEAKRLFQEVVVPNLDIFLVSAFGVPRPWPDLAVETINNLFERFLFRVDGNYDFVLASLWRKDKTWVAQRLMDAHVKAPLELTLILDHAIKHEWLHELASMLNGFGLDLAALAHSRSLLDLKDWKATNSPREEELGSALLTFLSIKAQHELAYQRTQREHSIMLPVKTVFAMLNVLEEILPKEPSAQLIAVQRTCITAYPRLINYGQDDELDRIIDNNGSVTNMLSEDAQHMMEQHYKQMYSQELKVRQIVDALAGYKSARDPYQQDVFACMIHGLFDEYTLYSTYPLEALATTAVLFGGIIQDKLIADLPLEIGLGMILEAVRDHLPEESMYKFGLQALLQFTPRLPEWPGFCHQLLQVPGLESTEPWKKAQKVIHDQQEDMLRNGHNDLMNGGGITNGNIDEMLAAEPAAPPFNSVNVDPLPPNSDFKDPDDDAQDKVQFLLNNITELNIGSKFIELKNALGETHQKWFAGHLVEERAKIMPNYHELYLGLVELFEDKVLWKLLLRETFISVSRLLNAESTLQSSIERTHLKNLGGWLGSMTLAKDKPIKHRNIAFKQLLLEACDTQRLIIVIPFVCKVLIEGRKSIVFKPPNPWLMDIIHLLIELYHNAELKLNLKFEIEVLCKGLNLDHKSIKPSTEFQSRIPPVEEATETMAVPDGLDRFENLSVNGLGGGIASGRFSPQEILATMPDLGPLLTYPPSNDMVNTRQLHDILKTAITRAVHEIISPVVERSVTIAAISTAQMIHKDFATEPNEARVRSAAINMVKKTAGSLALVTSKEPLRASMTNYIRTLSVEHQLPEGTIIMCVNSNLDLACSQVEKKAEERAVPEIEEILEPELEARRVHHMRRPDDPYIDPQLSRWAWTIPSPYKLQPSLTGLNQEQMAIYDEFARQPRLLPIADRGSVAGSLAGTTHVATASDATTSITNDLLRDQFPAVPNLPTPAETPTMPLINNHQPPYSQPSAALSNGRMPNMAMNPQGLPEKVQRLLTDLQQTTADIPEQHYMDLPRPHPVIEILDALYSLIIRSQQGQEPYDIWIAEQICGIVFSGSENTLVIECLVHVLENIIRIGGRCAVRVSMIIGQQVGEALLHVPLIVALVKAEMIDWARVDLATSTALAERKEGTLEFFLSLLEQVFLNDRPLALYTDVAKSLEVAFEWISKDPTLEVGQQLKEKLAASALPKSVGRSQDDRLAFRQDQMEYVFEEWAHLFSNPIAPERAALVFISHMYNRQLINDKEDLCLFLRLSIDTSVERFEQQFQMHGFLNDAYIPTDALAKLISLLIRGYEREGEVKGDKAAFLESILSVITLVLNHHHVMRGEGFNQKVFTRLFSSILCHLNTFSADLSETENREIILTFAEKLIKLQPAYFPGFVYGWMTLISHRFFLAPLMGLPDDMGWQPFAKLAECLLSYMGELLKPLQLSSAARDIYQATLKFFVVLQHDYPDFVVAHSSKLCAKVPSHCVQLLNLILSAHPTMPTLPDPLQPGLKIERIEEIRLSPEIVNIADIERTLQSTGLFEIVEQALQNGPSEDAVAHITHTIQRKQADVTGAGFVPVNVDLQLIESLVLHICMYAVTRARQKGELNSFARNSTDAVLISMLVHELNPEARHYLLTSMVNQLRFPNAHTHYFVQALLELFGNDVNDQEESDISQQILRVLLERAFISLPIPWGVLNMVIELVKNEKYTFFDLPYIKSTPDVRHLVLPRYSND
The following text describes a protein:
Function:
Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDIQWKKQITKSFSLTGFSIKADAMKCIINRIKNEGYDITQLIDNLLKNLDKSQYLQTIEGCFKLIDTINSSDAIEKEALKVIDAFNTPLFNFDSNSKQFIKSENFDRSLHGSSNSKSDLYRKRYLKVLQRTERNDYFSTPVLASDKLKNEYQTITPLSSLLGNTGRKHVLGTISQIEEDQFYIEDLNTNVKIDISKAKFEFGIVTINSIIQASGEFIDGVFIADKIQLPPTEERCETLKFLQNIDMFGERPQKKTMEQLIKYEKEKEDNSILFLSDVWLDSERVMERLDYLFGGYKDCPPFAMILMGNFTEHPLINGTQYQLKKYFNQLAMVIQKYPNIHQFTQFIFVPGPTDPTGSLLNILPKFPISNVFIKDFISLIPKSTFTTNPCRIRYCSQEIIIFRDDLTNKMRRHCILEPSQSCDISQHLIELICSNSHLCNLTLEDKPIYWNYDHAMSVYPLPDLLVIGDKSNQYEHSRADGTYSMNPSSFSTDYSFAHYIPANKQFYYNKADRPSDEIEDDDDDEEVENQNENENENENENENENENENNDNDKTQQKDTQGDGDDNDDDEIMIDENEKQKSRKRNKKVVIITKEDELNKLEDDEEILNSLDVQQQSENHADNNNNNINNNNNDDDNEDDEDSNYNNIESEVQEVEKEEEEDEEPIDNDKLDEFIE
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Sequence:
MCIGIAVIDCLIGRKQRIRMRKKSKLILALIAFNIIVALAIYHHFNSTKTKHKLAVVIPFRDRFDELMVMVPHLSRYLQSSRINFEIIVVNQVDQWRFNRAALLNVGFHLTNIKSDFDYIILHDVDLLPMSYQLNYAYPEDGPYHISSPDLHPIYKFSSYLGELNLPGIDCSIFDSHLLYFNNNIPQFYTAHIHRAYNIKNKNSAFRHIHDNNRRPRDMKEFYNQRQAKYQRDRVTGLSTLRYRLVSQHQLTVDSAKCRVYNVQLECNLAVTPWCQNKKKKNRNRKVANSTKAKSPKKSLLFAKTNLSV
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase.
Subcellular Localization:
Cytoplasm. Cell membrane.
Sequence:
MEYYTSKEVAEWLKSIGLEKYIEQFSQNNIEGRHLNHLTLPLLKDLGIENTAKGKQFLKQRDYLREFPRPCILRFIACNGQTRAVQSRGDYQKTLAIALKKFSLEDASKFIVCVSQSSRIKLITEEEFKQICFNSSSPERDRLIIVPKEKPCPSFEDLRRSWEIELAQPAALSSQSSLSPKLSSVLPTSTQKRSVRSNNAKPFESYQRPPSELINSRISDFFPDHQPKLLEKTISNSLRRNLSIRTSQGHNLGNFGQEILPRSSRRARPSELVCPLSSLRISVAEDVNRLPRIDRGFDPPLTVSSTQRISRPPSLQKSITMVGVEPLYQSNGNEKSSKYNVFSESAHGNHQVLSFSPGSSPSFIEQPSPISPTSTTSEDTNTLEEDTDDQSIKWIRGALIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRIGENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHPFVS
The following text describes a protein:
Function:
May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
Sequence:
MPLSTKDSLLVTQFRAITGTSSAEAAKYIKRYKHIEAAVDAFYNNEPAPRADPAQERKLGEIWEKFKDPSDPKLIKIDGTMELCEELDIDPGTDAVLFCLAADLGSKATGEWEKAPFVAGIASYPGNIDSLPKLKAYLPTLRKKLVSDPEYFKKVYNHAFQLARGGPQSLTRSLPLDTAIDLWTLFFPPAFNHSPSALSHLPDNSPPQFTQPEFDLWIEFMQQKNKAVSKDTWALLVDFARGIDKDFKEYDEDGAWPSMIDDFVEYVREQKRGQ
The following text describes a protein:
Function:
Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.
Subcellular Localization:
Cell membrane. Note=The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells. Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1.
Sequence:
MITPTSFEPVELLYSKKKVNRTNWKKNVLKSNPEINNLCERIYPINRAIQFGKQFHPGKAEVKQKLDKTAIIQLILQHLSTKGLKQTKQTLEKEARTTTPIVEGLNESRLVTYIRNALKDTDRIYDLSMEHTEYSKEERQSKITEREELLFQMDLLEDEDEDDGVNIWDEPTENIITEKVHTTEYDINKSKENKDDQDDEVVKFASLNKLVEHLTHDSKHDLQFLKTFLMTYQSFCTPEKLMSKLQQRYNCPSGHDEMATRNIQIRVINVLKGWVDNYYSDFDDKLIAMLRTFIDQIQIKFPAPASAVNKSLTKMVEKLSPVNDSKHIFNEKTPEPMVPKNIFSNNLSIYDIDEEEIARQLTLIEFEIYRNIKPPELLNQSWNKTKLKSRAPNVLKMIDRFNSVSMWVATMIIQTTKVKARARMMTRFIKIADHLKNLNNYNSLMAIIAGLNFSSVYRLKYTREELSAQTMRTYSDLEKIMNSEGSFKTYRTRLQNVPPMLPYLGVHLTDLTFIDENPNNFVTDVGGKQVSLINFTKRTLVFKIISLIQETQVVPYNLQPVHQIQEFLLNIRSDLKAHTLDQYQQELYRESLKREPKKAQRSDVL