lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSDKILSPMEDEELVQLFQSESFTNCMRRVLHLDVTEQLIQRTLKSFSKESKTSTNEKCHRTAKELRIEGNKYFKNKNFEKALDLYNKALTFSDLKVDEDGVGGSGENSEYVLCLANRSAVHYHLHHYQFCINDVQNSLGHNYQPTHKLILRRAQCFFHLNNFSEAKNDLMVLKMAPQNGAKPEEVDDWLRKIELQQQQKQPQQPQHHHLQQPRNEHTQEEILKVKGGKSDVLMQASRCVCVQFSEEKTRYLVARGELEEGDVLIMERPFVCLLLPPYYHSRCFNCLGDLENFYPCLTCRRVRYCSGECRSEAWRSHHHIECPYMEMLESGCQHQSIINSDTASHGTFSVLAVVSVIPLIPSIKLDTFECQTASVLLRCLEESSFFEGYKNLEEDYEGFRAFIGGLLLRHICQLICNAHAVNDLELTQLASSSLVDSEQQVRIATAIYPTASLMNHSCDPNTISCFHGDTLLVRALKRIKPGEEIFNCYGPHYKRMSRSDRQEALLSQYSFTCLCTACERENKHHDDDDDDDDDDDDDLKHVSTIAPCDDVFICKSCQGRLVRCSHHHHHHRHSPTHKSSSKQASSGDSISDNVISSRNISSTDDGDDDRMVKYVCVDCKTGADENHSKLISKNFDESNALFELANDHLRRGNTDEAYGLFERCCSLRKAIYQPMSIQVANVLDALAQSSSIIGDFPTSQSYLKCSLSIVEHVYGRKSIEHANEVRKYSEVCWQAGSLEEARDSAGKALRMFEVLYGHEHKSCHELRNAIASMNFCLS
The following text describes a protein:
Function:
Protects actin filaments from depolymerization. Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity).
Miscellaneous:
MISCELLANEOUS: 'Xin' means 'heart' in Chinese.
Subcellular Localization:
Cell junction, adherens junction. Cell junction, desmosome. Note=Colocalizes with actin stress fibers.
Domain:
Xin repeats bind F-actin.
Sequence:
MADTQTQVAPTPTMRMATAEDLPLPPPPALEDLPLPPPKESFSKFHQQRQASELRRLYRHIHPELRKNLAEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDAIGEHERPAAKEPVLCGDVQATSRKFEEGSFANSTDQEPTRPQPGGGDVRAARWLFETKPLDELTGQAKELEATVREPAASGDVQGTRMLFETRPLDRLGSRPSLQEQSPLELRSEIQELKGDVKKTVKLFQTEPLCAIQDAEGAIHEVKAACREEIQSNAVRSARWLFETRPLDAINQDPSQVRVIRGISLEEGARPDVSATRWIFETQPLDAIREILVDEKDFQPSPDLIPPGPDVQQQQHLFETRALDTLKGDEEAGAEAPPKEEVVPGDVRSTLWLFETKPLDAFRDKVQVGHLQRVDPQDGEGHLSSDSSSALPFSQSAPQRDELKGDVKTFKNLFETLPLDSIGQGEVLAHGSPSREEGTDSAGQAQGIGSPVYAMQDSKGRLHALTSVSREQIVGGDVQGYRWMFETQPLDQLGRSPSTIDVVRGITRQEVVAGDVGTARWLFETQPLEMIHQREQQERQKEEGKSQGDPQPEAPPKGDVQTIRWLFETCPMSELAEKQGSEVTDPTAKAEAQSCTWMFKPQPVDRPVGSREQHLQVSQVPAGERQTDRHVFETEPLQASGRPCGRRPVRYCSRVEIPSGQVSRQKEVFQALEAGKKEEQEPRVIAGSIPAGSVHKFTWLFENCPMGSLAAESIQGGNLLEEQPMSPSGNRMQESQETAAEGTLRTLHATPGILHHGGILMEARGPGELCLAKYVLSGTGQGHPYIRKEELVSGELPRIICQVLRRPDVDQQGLLVQEDPTGQLQLKPLRLPTPGSSGNIEDMDPELQQLLACGLGTSVARTGLVMQETEQGLVALTAYSLQPRLTSKASERSSVQLLASCIDKGDLSGLHSLRWEPPADPSPVPASEGAQSLHPTESIIHVPPLDPSMGMGHLRASGATPCPPQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSGQKGMAVLGKSEGATTTPPGPGAPDLLAAMQSLRMATAEAQSLHQQVLNKHKQGPTPTATSNPIQDGLRKAGATQSNIRPGGGSDPRIPAAPRKVSREEQALPRGLPGGWVTIQDGIYTAHPVRTFDPPGGVQLSQREPQSRHRETALSVQAPRPLQGGPGQSTGPGREEPGGCTQMAWGPPGKAMAEVCPGGLQAAETTLKTAPLGRHILASGPQAAGASPHPHNAFVPPPPTLPAAVTGPDFPAGAHRAEDSIQQASEPLKDPLLHSHSSPAGQRTPGGSQTKTPKLDPTMPPKKKPQLPPKPAHLTQSHPPQRLPKPLPLSPSFSSEVGQREHQRGERDTAIPQPAKVPTTVDQGHIPLARCPSGHSQPSLQHGLSTTAPRPTKNQATGSNAQSSEPPKLNALNHDPTSPQWGPGPSGEQPMEGSHQGAPESPDSLQRNQKELQGLLNQVQALEKEAASSVDVQALRRLFEAVPQLGGAAPQAPAAHQKPEASVEQAFGELTRVSTEVAQLKEQTLARLLDIEEAVHKALSSMSSLQPEASARGHFQGPPKDHSAHKISVTVSSSARPSGSGQEVGGQTAVKNQAKVECHTEAQSQVKIRNHTEARGHTASTAPSTRRQETSREYLCPPRVLPSSRDSPSSPTFISIQSATRKPLETPSFKGNPDVSVKSTQLAQDIGQALLHQKGVQDKTGKKDITQCSVQPEPAPPSASPLPRGWQKSVLELQTGPGSSQHYGAMRTVTEQYEEVDQFGNTVLMSSTTVTEQAEPPRNPGSHLGLHASPLLRQFLHSPAGFSSDLTEAETVQVSCSYSQPAAQ
The following text describes a protein:
Function:
Voltage-gated, high-affinity calcium channel that functions together with yam8 to mediate calcium entry into cells (By similarity). Required during conditions of environmental stress (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSSSNSDPSSSPDNTDFIPLKDNPKDTSSYINKKNPFVNDSFDSHDDSYLDNVNPFEYNVADDEDTISMTSDGVEFHNLGITETVDEQDKILSELQLAYPTVSRYSETLDKGLLNGDKTTKGDYTSLRRFRKPFLFDKLSPYFTHFFSEIYAAVLRVVGPPRANETPGRNLPFSPILRQIYNHPLYNIFIFVVIVLHAVLLMIRSDDPHDKSQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFVAIVALWISVIGKKQQGIFRLFSMIACLRLTRLLNITRKTETILKSLKESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCVWLGDYGDQYLPTGQFCGGHWENGIKRAYLDKNGFPSNVNPRGFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISAYFLTLWLMSLVIAVVTSSFIDLQHSGKNQKEQKSVDKHLIRNKLCEKYLFYSNFIWISFIVAQFVTLCTQTYDQTSSTANRYLIFYACVDFLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTLLPSIRKNPVAFGWLSIFAIARIYRCILLIPYTRKIAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAISFATTYESFLYMYQILTSENWTDVMFAIQARLAHLHLSWIPGAFFTLWFLFSNNVVLSMFIAVIQVNFAPSESDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRKGKTVDESHYEWLYEDNIIKGFLRVTNIPPKEPLKPSLDTSPELSKYSLAKLSNNFKRFVMRDDPFSQAYFKRVIGIRWEKDMNLKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPSNRIRRFCQRLVMPGVNERYGGVEPYQWVYRVIQVFIYACILTAVIIECIATPIYERDHLLNDKQHAWFVWTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHALLSRAFRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSCNDDNVLSASQCVLEYASTPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEIASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERTGSAFFTAEQRAWLELRRKIKSMRPSKRPAIRPLGLRGLCYDFAVQKHGIWRRTFTGLYIVHLLFLLTIFYPCPIAYTYVRNSIFLILSICYTINICVKVYGLSFYYFFHSFWNMFDVVVTLGSLTCNIAILAKFENRSLTLLQTTLLVLVTVHLIPKFDNFDQLSKTVVASLPSIFSLIATWIVLYITFAIAFNQIFGLTKLGLNGGPNKNFRSIRNALVLLFTMTFGEGWNDVMHDYTISYPNCVNGDDFYNSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFTNLQRNDFRQFKDSWAPFDPMVTGYIPKRNAVKFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQQSVPMLENPLMGSEINLEALDQIIDTIDVNVVKERRNVLNSLCTEIMTLPGNVISFSNILMLVVLHKIVDHREAFPISDYIRRAYVLSELEKSIRMEKLLGLVETSIIRKTFLQHMEEKKKALENPFILLSEVSEILPETPIQEVLRQHNADPEQLLMSTRTPSVSDRSFSIVESTVPTIASGEGDDNHSVEDHLKVPTDNEPRRSPSLKEVLLRGSHSLHSNNDRTSFDIEAGFGTAESDFQFGGATEDINRIADRIDDYLDRDSFKG
The following text describes a protein:
Function:
As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Associated with microtubules. Localized at the distal tip of the cilium.
Sequence:
MEAEPERAEAPRRGGVAAVLKMGRRARQDIFAGENLSRKNSPSASLGEVPPPKPPRRQGGWADDPVLAPTKSGRKHAEEVEDHRLRQQSLEASDDGGDIPVIPDLEDVQDEDLAMQVAAPPSVQVNRVLTYHDLDKDLMKYAAFQTLDGEVDLKLLTKVLAPEHELREDDVSWDWDHLFTEVSSELVTEWDLGQSEREDHISLP
The following text describes a protein:
Function:
Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Subcellular Localization:
Secreted.
Sequence:
MMSASTMAKVMILMLAVCLLTQADGKPVKKRAVSEIQLMHNLGKHLASVERMQWLRKKLQDVHNFVSLGVQMAAREGSYQRPTKKEENVLVDGNSKSLGEGDKADVDVLVKAKSQ
The following text describes a protein:
Function:
Folate-dependent protein involved in Fe/S cluster biogenesis. Functionally complements an E.coli mutant defective in ygfZ.
Subcellular Localization:
Mitochondrion.
Sequence:
MFRFNFRREISKYTGIYHRKIHSGLEDAGPMASRLKSRSVVRFSGPDTVKFLQGLLTNDVRRFGESSGEKNSAVPTPNMASVTNPPMYAALLTPQGRFLYDFFLYSPSRPDEKLDRTGSGPGSDSGRDGSVELFADVDVDVLDELLETLKKYRLRSKVDIENVAEEFSCWQRYGRNLTGSSSVGWGGGVDRAGESTASGNKYGWQWYKDPRLECLGYRSIFPSDATPPLVEADKETDESNYLLWRLEHGVAEGSAEIPKGEAIPLEYNFVGLNAISFDKGCYVGQELIARTHHRGVIRKRLIPLRFIDSNGKELNQKIAAGAEVVESGTGKKMGTVSTALGSRGMGVMRVEEAFKPSAELAVKDSEEVKVEAIKPTWWPAEWFQQNQSGVAAA
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MEEWDVPQMKKEVESLKYQLAFKREMSSKTIPELLKWIEDGIPKDPFLNPDLMKNNPWVEKAKCTIL
The following text describes a protein:
Function:
Required during maturation of the 40S ribosomal subunit in the nucleolus.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAGEQQAAHRPGAYKQQNKPHKSGRHRGRGAQDRENKGRVAAKILGKKNKKDLRKLDRRHKANQIRRQRKDAVLAEKRSLGTKDGPPHLVIAISLHARAVKDDLFSLVQNNEGDILHVNDQIKGLLALVCPKVKQRWCFIQANRDDLCSLLDLAKVADTLLFLLDPQEGWDSYGDYCLSCLFAQGLPSYVLAVQGMNYIPIKKRADIKKQLSKVIENRFTDAKLFQLDTEQEAAVLIRQISTQKQRHLAFRSRRSYMLAQRADFQPTDESGLVGTLKLSGYVRGQELNVNRLVHIVGHGDFHMSQIDAPPDPYPLNPRVHKPKTKSGQDMEMSDEPATGSEMEQDIKVLMKADPSAQESLQCEVVPDPMEGEQTWPTEEELKEAEDALKGTSKVVKKVPKGTSAYQAAWILDDEGDGEEESDDDDDEDMEEDAEDAMDDAYSEEEDGSGNEEAEESETLTIPDSTRDDKYDENVDEQEEEQMLEKYKLQRQDEVFPDEVDTPRDQIARIRFQKYRGLKSFRTSPWDVKENLPRDYARIFQFHDFFRTRKRVFKEEEEKDEGAMVGWYVTVHISAVPVSVMEHFKHGLPLVLCSLLPHEQKMSVMNMLVRRHPGNNEPIKAKEELIFHCGFRRFRASPLFSQHSSADKHKSERFLRSDTSVVVTVYAPITFPPASVLVFKQRYNGMQDLVATGSLLNVNPDRIVIKRIVLSGHPFKIMKRTAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPLGTHGHMKCHFDGQLKSQDTVLMNLYKRVYPKWTFDPYVPRPVTWVKNENTVDITEVEMD
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASLQFHGNVDADIRYDISLDPARESNLFRLLMGLQLANGTKPSPRLPKWWPKRLEMIGKVLPKAYCSMVIFTSLHLGVLFTKTTLDVLPTGELQAITDALTMTIIYFFTGYGTIYWCLRSRRLLAYMEHMNREYRHHSLAGVTFVSSHAAFRMSRNFTVVWIMSCLLGVISWGVSPLMLGIRMLPLQCWYPFDALGPGTYTAVYATQLFGQIMVGMTFGFGGSLFVTLSLLLLGQFDVLYCSLKNLDAHTKLLGGESVNGLSSLQEELLLGDSKRELNQYVLLQEHPTDLLRLSAGRKCPDQGNAFHNALVECIRLHRFILHCSQELENLFSPYCLVKSLQITFQLCLLVFVGVSGTREVLRIVNQLQYLGLTIFELLMFTYCGELLSRHSIRSGDAFWRGAWWKHAHFIRQDILIFLVNSRRAVHVTAGKFYVMDVNRLRSVITQAFSFLTLLQKLAAKKTESEL
The following text describes a protein:
Function:
Probable transcription factor that regulates development of the tail phasmid sensory organs. Involved in migration and differentiation of lateral neuroblasts. Involved in control of cell fate in the T cell lineage.
Subcellular Localization:
Nucleus.
Sequence:
MVSTHSSQYITDFTPVPAEPGKSPLALLAKTCETIGLPEGSSKKNGASSSSSPQGKKDEKNHILHHQHHQQQQQSKQKSSPRSTPQSKEPTLTFPGLPKPSFPMGMPGMMQGFPFFNPMMTAYGCFPGAFPMSQGFMGAQRLPCPFAMMRQPCANPACVQCPSSSSNAAKNGQMTAEMMSQFAAHPLFSMYAGMMPGVPTSSYQALLAASAAASTSAGPTDYSNVASTSKASPQPKPTAQKSQKSAKFPCNWVDSDVPCGKVFDEENELASHVKKMHAPSPSSSASSEQSTSTGKASRSSTTTPHRFNPYGKPVAPAPPTMQQMGMNMAMNPLVLPFSLQAMYSNRLMSTVAHQ
The following text describes a protein:
Function:
Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
Sequence:
MTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVGDFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVMLLVIMCLTGAVGHGIWLSRYEKMHFFNVPEPDGHIISPLLAGFYMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSIVQCRALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRLESYQEAVSEDEDFIDTVSGSLSNMAKPRAPSCRTVHNGPLGNKPSNHLAGSSFTLGSGEGASEVPHSRQAAFSSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYIIDFFIALAICNTVVVSAPNQPRQKIRHPSLGGLPIKSLEEIKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRLPLFSRMKPASPVEEEVSQVCESPQCSSSSACCTETEKQHGDAGLLNGKAESLPGQPLACNLCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVDFAALGPLTFQLLHILPFDSVRKRMSVVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYAKQGLRTLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQEGVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMSTILKELQKKTQALPEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQKQFLELTSWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAFYQSLVCFFVPYFTYQGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVIIGSILSYFLFAIVFGAMCVTCNPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVLQGSLFPSPILRAKHFDRLTPEERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPMPGPSAVFAMKSASSCAIEQGNLSLCETALDQGYSETKAFEMAGPSKGKES
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPVLGFLEESDEYFEEYDETKLPTTGLEYLRRVQQEAERCPEVVIADLTNKEFGKKQTVKINQDSGCAPAPTGAAPSLEWQQQQAADFADVRQCLANYKTKANSLTDANISWPSKNDEIQWCRFCLGREAAIHICKAFGYPDSRLTHPQQMPEMDNFTEQQWENGSPPTLTMMVKLNQTLVQRLLEWHTLWMSVLGYSHDQGRWIYSLLVCLEKPLLADCTATLRTLARQCTECRLTQMPMNEKNVELVTSLNLIIALVSRYFGQTDLADPG
The following text describes a protein:
Function:
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MATNTITTTKVTTTTTDVTGLSLIAAHSHISGLGLDDNLQPKENAQGMVGQLSARKAAGVILKMVEAGKIAGRAVLIAGPPSTGKTAIAMGLSQSLGNQVPFTALAASEVFSLELSKTEALTQAFRKSIGIKIKEETEIIEGEVVEIQIDRTITGGHKQGKLTIKTTDMETIYELGNKMIEGLTKEKVLAGDVISIDKASGKITKLGRSFTRARDYDAMGPETKFVQCPEGELQKRKEVVHTISLHEIDVINSRQQGFLALFSGDTGEIRPEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFSPIVIMATNRGVSRIRGTDYKSPHGMPMDLLDRSITIHTTSYTADEIRTILSIRATEEEVELSGDALALLTKIGQETSLRYAANLISVSQQIALKKKNNTVDLQDIKRAYMLFLDSDRSVQYLEENADQYIDDYGRVTIGQESTDGSTQPQAKQQEVAQPEATQPQSQPEDDKMETD
The following text describes a protein:
Function:
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
Subcellular Localization:
Sarcoplasmic reticulum lumen.
Sequence:
MTWIKLASLALVVVLASAGISKNEDLECMFLGYPDLEYDGFDRTEVLTEKNFNRTVFAEDTKSVVFFNDVEEDDSELDQYECFLQLSAQIMTKRGYNFYTVNTTKEHRLRKQEEVEKGEDTIHVYKDGYKIEYNGVRDPETFVSWLMDIPDDPVTIINDEHDLEEFENMDDECVRIIGYFEPGSVALKEFEEAAEDFMGEIEFFAVVTSKWARKVGLKRVGEVQMRRPFEEDPLFAPTSADTEEEFEDWVEKNKEPVMQKLTLDNYFNLWRDPEEEERMILAFVDEETREGRAMKRLLDKIADENSEHAGTLEIILVDPDEFPLMVDVWEDMFGIDIEEGPQIGLIDISEKEGIWFDMSQVNLDDPKKHSDSNFEALQSWIDQILSGSISLDDDDDDEPEPPAPPPTPKGKKSRKEL
The following text describes a protein:
Function:
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN). Methyltransferase that mediates the conversion of putrescine to N-methylputrescine. Promotes leaves ripening.
Sequence:
MEVISTNTNGSTIFKSGAIPMNGHHNGTSKHQNGHKNGTSEQQNGTISLDNGNELLGNSNCIKPGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPTIEKIDIVEIDDVVVDVSRKFFPYLAANFNDPRVTLVLGDGAAFVKAAQAEYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEIDFKNPVNPIDKETAQVKSKLAPLKFYNSDIHKAAFILPSFARSMIES
The following text describes a protein:
Function:
Plays an important role in the establishment of latent viral infection. Modulates the expression of several host cell surface receptors such as TNFR1, CD36 or the MRP1 transporter during productive infection. For instance, associates with host MRP1 and induces its lysosomal degradation. Plays an inhibitory role in the host cGAS/STING/TBK1 pathway and upstream of IRF3 phosphorylation and NF-kappa-B leading to inhibition of interferon beta production during both lytic and latent infections. Also participates in the establishment of latency by sustaining an innate immune response through phosphorylation and activation of host STAT1.
Subcellular Localization:
Host Golgi apparatus membrane.
Sequence:
MDDLPLNVGLPIIGVMLVLIVAILCYLAYHWHDTFKLVRMFLSYRWLIRCCELYGEYERRFADLSSLGLGAVRRESDRRYRFSERPDEILVRWEEVSSQCSYASSRITDRRAGSSSSSSVHVANQRNSVPPPDMAVTAPLTDVDLLKPVTGSATQFTTVAMVHYHQEYT
The following text describes a protein:
Function:
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MWFCCVLLLSLLSDVSGASDSKAITTTLTTKWANTPLLLEASEFLAEESQEKFWDFVEANQNIEGEHDDTDQAYYELIVKKAGALLTSVQLNMLKFALSLRAYSSTVHTFQQIASTEPPPSGCSAFISVHGEKTCDEEKLESLLKTASERPKPYLFKGDHRYPGSNPDAPVVILYAQIGKSDFQQFHRVLTSKVNDGSVTYVLRHYVPRVHLSGYGVELAIKSQEYKAKDDTQVQGEEVNATVIGENDPVDEVQGFLFGKLKTLYPELKEQLKELRKHLVESTNEMAPLKVWQMQDLSFQTAARILAAPAVDALNVMKDLSQNFPTKARSITKTVVNSEIRKEIIENQKFFKGNLGLQPGDSVLFINGLHIDLETQDIFSVFDVLRSEARVMEGLRSLLIETPYIHDILKLNVQPADSDYAVDIRNPAISWINNLETDHRYSSWPYNVQELLRPTFPGVIRQIRRNFHNLVVILDPTQENSAELLSVAEMFYSNNIPLRIGLVFVVSDEDDIDGMQDAGVALVRAYNYISEEVDSQAAFDGVITMFNRVPAGGKLSVSDVVKVLEKRFPYVEVSSILGADSSYDNNRKEGRAYYEQTGVGPLPVVMYNGIPYRKEQLDPDELETVTMQKILETTSVYQRAVYLGELATDHDVVDFVMNQPNVVPRINPRVLSTSRTYLDLSDTNNFFIDDYARFSTLSSKKKNGAVANSMNYMTKKDDGYIRPVTFWVVGDFDKPSGRRLLYDAIRHMKTSNNVRLGMINNPSANPSAETSRVTRAIWTAMQTQSANNAKNFITKMTKEETAAALEKGVDIADFSVGGMDLSLFRSAYDSPKFDFLLSHAAYCRDVLKLKKGQRAVISNGRVIGPLEEEEVFNQDDFLLLENIILKTSGERIKSKVKHFGIEEDRASDLVMKVDALLSSQPKGEARVDYGFADDRHSAVKIRPKEGDIYFDVVAVVDPVTRDAQKLTPLLLVLKQLVNVNLRVFMNCQSKLSDLPLKSFYRYVLEPEVAFQADSSFSSGPMATFLDMPQSPLFTLNLHTPENWMVESVRTRYDLDNIYMQEVENIVAAEYELEHLLLEGHCFDVSSGQPPRGLQFTLGTASEPVIVDTIVMANLGYFQLKASPGAWMLKLRKGRSDEIYKIYSHDGTDSPTDSDDIIVVLNNFKSRIIKVKVQKKPDKFNEELLSDGTDEDDTGFWKSLARGFTGGGKAEEPKQEKDDVINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKDFIPHMAKQYGFQYELVQYNWPRWLHQQTEKQRIIWGYKILFLDVLFPLAVDKILFVDADQIVRTDLKELRDFDLEGAPYGYTPFCESRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDSSKKKAKTIDLCNNPMTKEPKLQAAVRIVAEWTNYDQEIKRLQTRVQEGANHTARQQSTGTQHSSQQQRAAAHPCPHTHTSVLTVPLSDVHTEL
The following text describes a protein:
Function:
DNA polymerase alpha mutation suppressor. Suppressor of group II intron splicing defects of a mutation in MRS2. May play a role in mitochondrial mRNA splicing.
Miscellaneous:
MISCELLANEOUS: Present with 2190 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body. Cytoplasm, Stress granule.
Sequence:
MGTNNTSNNNGTTKKMSLEEFLGNDTLGESVWDEEDINLDAISNTTNIDILKQTKAGEHQRDGHQQHPHGGHGPMNRSRFSNAGPFGGGSMGDFANHHHPLQHQQGPPYIVKFSDLPPRFSNFDIEDLFQAKFTKFIKFKLFWEINKNPSISTLKSGSIFDQNFKRDSKVAFVELYTSRDMDKILNYWTTPLKEIYHITTAPAEFEDFKDYSTKVKLLTDPKDDAGKPFITKTQRSKSNPFGSAKPVDTQSKILDIEEKMENLHVEDTTTLRASLIPSSDSMATTATGSKITILKKQTPTEEESHSATPTPKPLSYSEVVERSVVNETSKKGTPLSKLDSPALELQSKPDKSDEFKGGDEQGFEKGGDDKAQLDVSNDKDKGSETDVDKQFTFKNVEREHSMSRTKYNGNHNNNNGNFRGSNRYRGGPNGSSYKGGHNNRGNRGGYRGGSSYNNNNNNTNDNNNNNNNSSSNNNNGSRYHDRQNNEEGLTSDSSLDASGNKKNDFTNSTSNTQQYSIFKPASGFLGQGNNDSIRNNGRGNYNSSGMNGGSRGRGFGRGRGFGRGAYNNRGSRGGRGSSGNYSNYNNRTTDMPL
The following text describes a protein:
Function:
Deacetylase involved in the biosynthesis of butirosin by mediating deacetylation of 2'-N-acetylparomamine.
Sequence:
MNQDKRAFMFISPHFDDVILSCASTLMELMNQGHTCKVLTVFGGCPSVRFQPGEIARQYAAEDLGLFEDEIEGDHLSILVARRLQEDQQAFRHLPGVQVEVLSFPDAIYRENKGQPYYRTEADLFGIPDKQDEDIFLPKIETYLQSCDLARKYTWVFPAISKHVDHRLLTKAGLRLMSQGYPVLFYSEFPYWQQHNEFLQDGWRQLELRNSVYTPVKRAAVLEYKTQLLGLFGEEAETKINNGGVLSEAELFWIQETDTQAWRVFRSLSPEPLQT
The following text describes a protein:
Function:
Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23 and rps2302), thereby regulating protein translation termination efficiency. Negative regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDTQQPTVLDRFAPHALDTSEAERLSREYHKNGPYNHVVIRPLINDTLLRNVRKELMENIHFTEKVTDIYRVWQTGDLANLDGLDKKEQNMLKYLRQVRDALYSEEFRSHVQKITGCGPLSASKKDLSVNVYSKGCHLMNHDDVIGTRCISYILYLVEPDEGWKPEYGGALRLFPTLQPSFPAADFCHSIPPQWNQLSFFRVKPGHSFHDVEEVYVDKPRMAISGWFHYPQPGEPGYDANYCDNTVSTLQSLTMKQMDLELPRFSYYPVVKPEPLSKQDTDILSNYINPLYLTPDGIEKLSKRFFQDSVIVLVEFLNQEFANTLLKRIIDAERQPTPMHSSEVSFPWKTAIPPHKHRYLYLDHEEFGPDIILPMDLQRLPAFQRWIQLVSGLPLRSFHQVGRRFRPGSDFTLATTNDTALLEATLCLSPGTGIANTDNGAYDIYMIGDEDPDVDAAVYRGDQQDDSILLSLPAAWNVFSLVYRDEGVLQFVKYVSRQAESSRWDIYSQWNPVAE
The following text describes a protein:
Function:
Modulates resistance against pathogens including oomycetes (e.g. Hyaloperonospora parasitica and Phytophthora brassicae) and fungi (e.g. Phytophthora brassicae). Controls the abscisic acid-mediated (ABA) signaling pathways. Regulator of the flowering time in response to stress (e.g. UV-C). Regulates polar lipid content; promotes phosphatidylinositol (PI) and 18:0 but prevents 18:2 and 18:3 polar lipids accumulation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MNQSAQNYFSVQKPSETSSGPYTSPPPIGYPTRDAVVGDPPAAAVETNSKGVNPEAIMSCFSTCMECIFCCGVCSSLCTSE
The following text describes a protein:
Function:
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDARVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATADARFWKGPSEAPSGQA