lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.
Subcellular Localization:
Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus. Chromosome, telomere. Nucleus envelope. Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles.
Domain:
The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.
Sequence:
MDMPEDQAGGPTAKMYLWDQAEDRSLGTLLSLEEQILNSTFEACDPQRTGTVAVTHLLAYLEAVTGRGPQDARLQTLACSLDPSGEGPQATVDLDTFLVVMRDWITACQLDGGLELEEETAFEGALTSQQLPSGCPEVEDPANLESFGGEDPRPELPATADLLSSLEDLELSNRRLAGENAKLQRSVETAEEGSARLGEEISALRKQLRSTQQALQLARGVDEELEDLKTLAKSLEEQNRSLLAQARHTEKEQQRLVAEMETLQEENGKLLAERDGVKRRSEELASEKDILKRQLYECEHLICQRDAILSERTRHAESLTKTLEEYRATTQELRLEISHLEEQLSQTQEGLDELSEGAQVRRVDCTNLLPPSLGVELQAIQQRNLQEESAHPQEGREEPSTRLPRREEEDGAEIQVMVDLPLHPEDSHPGDILGNPPESSPSEPELQQALVPMVKELVPVRRPVWGQLCLWPLHLRRLRVTRHLLIPAPLLGLLLLLLLSVLLLGQSPPPTWPHLQLCYLQPPPV
The following text describes a protein:
Function:
May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.
Sequence:
MAATAWGIRSSGIRGASPVMSACVSPAEVILGADHQQQMYCHLLCGLRRWDAVDCIRAPYAAALARALRLLQSKWRQLCDDLECGTVCADVVTDAAMRGAVQDGVLAGPCPELAGRVRRICERDDWRGVLRQLWPDARYISCVTTGTMEQYFPAIKHFAGEALPVLGTDYLASECAIGINLERTSPPEETTYVLLPRAAYFEFIPFDMDAAGRGAAAAEPVDIAGVEAGKTYELVATTFRGLYRYKVGDVVKIAGFHHSSPRLQFVTRAPPPQEHGEVLTERDVMAAMDTFQLMLKDGGEVIEFAAFIIDGDGGQRRRRCATIAVEVSNGSKLLDHERSAAFLRRCTAPLEGCLGGAYRLSRATGDVAPLEVAVVRPGTFDRLAEAAIRGGAPANQYKPPRSSGTGTSSMCCNPPWCAAAAQSLNQLLTSICLIVSLNQRQFLDRESNSGTDKVFISDSILNFQHWGGFSLRFDLQEESLTLYKDHPS
The following text describes a protein:
Function:
Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes involved in colanic acid capsule synthesis.
Sequence:
MSTIIMDLCSYTRLGLTGYLLSRGVKKREINDIETVDDLAIACDSQRPSVVFINEDCFIHDASNSQRIKLIINQHPNTLFIVFMAIANVHFDEYLLVRKNLLISSKSIKPESLDDILGDILKKETTITSFLNMPTLSLSRTESSMLRMWMAGQGTIQISDQMNIKAKTVSSHKGNIKRKIKTHNKQVIYHVVRLTDNVTNGIFVNMR
The following text describes a protein:
Function:
Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).
Subcellular Localization:
Secreted. Cell projection, neuron projection. Note=In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex.
Sequence:
MTLRAVGVRLLGGLLLFALLAAGAAPLGWDLPESRSRASKIRVHPRGNLWATGHFMGKKSLEPPSPSLLGTAPHTSLRDQTPQLSHHLLRVLLQKQALGMSLSVPAPNTQHRRLLVQTLQK
The following text describes a protein:
Function:
Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix. Note=Cycles between the cytosol and the peroxisome matrix. Following binding to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, recruited to the docking complex, composed of PEX13 and PEX14, leading to translocation into the peroxisome matrix along with cargo proteins. Export and recycling to the cytosol is initiated by binding to the PEX2-PEX10-PEX12 ligase complex via its unstructured N-terminus that inserts into the ligase pore and emerges in the cytosol. Cys-7 of PEX5 is then monoubiquitinated, promoting its extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex (By similarity). Extraction is accompanied by unfolding of the TPR repeats and release of bound cargo in the peroxisome matrix (By similarity). The TPR repeats refold in the cytosol and ubiquitination is removed by deubiquitinating enzyme UBP15, resetting PEX5 for a subsequent import cycle (By similarity).
Domain:
The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type); The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex; The amphipathic helix 1 (AH1) is required for extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex.
Sequence:
MSVEAGCSTLSNPLKKLTSTAVVNNSTPSAQYRKHLTKSQSRTYAPLQTLSEDQFTSFKNLQGNNSPLGNVVKNPVSLKTGNHTGTTTRGGSKENWVHSFSSLQQQNSKSAWTSEFSEVFLNSSENDRFRNLNQPLKQSFFGSAGLNLSSNTEIPLQSSLAIDETELAKKFEEASQISNKLEKEKDATGSKSIEELWEEHQKQLKNAGLEPASLEEYQKQWEDFLKSNNISDDPYTSSVNSFANDNLAHNKNIDPQIFQHSDTDNVVENSLQTEDVYSQNQDESSEVVKELNGIDPFVEAMNLIKNGGSISKAAVLLEQSVKENPQHFEAWKWLGRIHTLLGNESRVVEALLEAVKLDSTNLDLMMDLAVSYVNQSLNVQALVCLEDWIVNSFPQYRNRFAKINERFEEKDSANDLLKMQMYFLDVAYELSLAKKRSSKVQAGLGIIMYMLKEYERSADCFRQALQDEPSNEILWNKLGAALTNAEKNTEAVSSYNRAVSLQPQYVRVRSNMAVSNINLGYFEDAAKHLLAAIDIIQNSSTSMESCESNEELWEMLRKVFLIGFQSTDLASQSYPGANTSYIRAQLSDLQGWPGVELE
The following text describes a protein:
Function:
Putative metalloproteinase that plays a role in left-right patterning process.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLLLLLLLGAATSRCLHDETQQSVRLLRPPFSQLPLNFRSSSLILPGSRDPQPLRIQTCYIGDPVSDGAWDPEGYGMKGGSRALAAVREAAQRLQGVLAVRGPLLLSRDPAQYCHAVWGDPDAPNYHRCSLLNPGYKGETCLGAKIPDAHLRGYALWPEAGPPQLVQPDGPGVQNTDPSIIAYAACCQLDSEDRPLAGTIVFCAQHLTSPSLSHSDIVMATLHELLHALGFSGQLFKKWRDCPSGPSVRENCSTRQQVTRRDEWGQLLLTTPTVSRSLAKHLGVLGVSPGVPLEEEQGSLSSHWEARLLQGSVMIATFDGAQRTRLDPITLAAFKDSGWYQVNHSAAEELLWGQGSGLEFGLVTTCGTDSSDFFCTGSGLGCHYLHLDKGSCSSDPTLEGCRMFKPLANGSECWKKENGVPPGAENPHGEIYHSQSRCFLANLTSQLLPGEKTRQPSQIPAPKEVELAGRCYLHHCTERGAYKVQAEGSPWASCLPGKAIQIPGYYGLLFCPRGRLCQTNGGIDAATSPPVSPSTQDLVFQLALGLAGPPDHSLGKEEREELTEAVLQALVSRGGTGRCYFHGPLITTSLLFTVHMWKSPGCQGPSVGLLHRTLTLTLQKQPLEVYYGGASFTTEHSKFLVTSDHNPSMTYVGLSMGLCLMLLLLVGALGTVAYKKRATLQVGPSAPYHSPGLQSTTSSPAGGMREV
The following text describes a protein:
Function:
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.
Subcellular Localization:
[Isoform 2]: Cytoplasm. Nucleus; [Isoform 1]: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.
Domain:
The J domain is sufficient to interact with HSP70 (HSPA1A or HSPA1B) and activate its ATPase activity. The J domain is also required for the HSP70-mediated and ubiquitin-dependent proteasomal degradation of proteins like ATXN3. The J domain is required to reduce PRKN cytoplasmic aggregation; The UIM domains mediate interaction with ubiquitinated chaperone clients and with the proteasome. The UIM domains may have an opposite activity to the J domain, binding ubiquitinated proteins and protecting them from HSP70-mediated proteasomal degradation. The UIM domains are not required to reduce PRKN cytoplasmic aggregation.
Sequence:
MASYYEILDVPRSASPDDIKKAYRKKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGAGSGPSRSETGGAGPGFTFTFRSPEEVFREFFGSGDPFSELFDDLGVFSELQNQGPRLTGPFFTFSSSFPANSDFSSSSFSFSPGAGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVSINGVPDDLALGLELSRREQQPSVAPGLGVMQVRPTSLSRPPDHDLSEDEDLQLAMAYSLSEMEAAGQKPAGGRGAQQRQHGQPKAQHRDLDVGGTHKSVRGEAAKLSPSSEEKASRCHIL
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAYLPKDPSAPQRWICVYPVYIDKNKKIPEGRRVCKEKACENPTAEEIRDICRSQGFDAEIERKQYPRNSYFDNPSKGRVRIRMFNNDQTLANPKFKTRKQLLVFIGEMIPKLKSRQAPKGAEGGASGADAGGNVGGSTSKKKKNKKGKR
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MAEQDGAAGQSPLDSPPGVSAENGDENTEQHQPFFSMCQPIRSVSYANSWESCFAPAANENDHNSGLNSMVDDHILITSASLGSKQPQPEDISGTVDDEGKPCSPHSIDKEASLVQDVMEMEQSMDEIDVPHGEASEQPEPLSTEQPDSTGGMDLWDDKDNQKLLPLNTDRWNSNIGETCDAEDKQFPLSFSYRRQPQSVMIKMDSVLSVPLKNMSMNQFEELSSDFRPGQQEDAHEFLRCLLDNLHKCTLDPMSKGKGSSFDEESIVKDIFGGQLKSQLSCCECGHSSETFEPFLDLSLEIDQVDHLVDAMESFTKVEQIGDSEDKLTCERCNAQVCKNKQLTLHRAPDVIAFHLKRFTTLDNSVEKIDKHVVYPSEVDLKPFHSNPDTVGELKYDLYGVVEHSGLPNYGHYVCSIRSSPSTWYLMNDSHVDSITDASALNKEAYILFYVRQGKFPWFSSLLEVKDALHAEDARGASPVSVLENIDANCSTSSGGGSSSNSGDKLEKNEARQLEELEKDETSQYKVSFCHEEPSKRSSLGASNINNTRDEISPPRASLQDDVVRCPRSVETTNLDRPSTPLPSKRSFSHNEFGVFEFEDFEFQPQFIVQLMFLLVSFTDDDEDTPLLPDLKFHPKAKKPKAASASKAVKGPSIDQNARRLMSGMPSSRRKGLLDCMVTQQNAHQESRSRRCPTSDPLDKKKRKLVQC
The following text describes a protein:
Function:
Transcription factor necessary to sustain growth on non-fermentative carbon sources such as sodium acetate, acetic acid, or ethanol. Plays a role in hyphal formation.
Subcellular Localization:
Nucleus.
Sequence:
MPKREIEDTQSPYSSTGLVSTGESPKTSTSTPTSSTNNRAATTTTNNTSTTSTSLLKSNSNLQPIAMTPSVSSTSLAINKPKSQENKRRRVTRACDTCRQKKVKCDGKQPCIHCTVYSYKCSYDQPNIRNKKNSGIPIPSQPSPAILQVAAQAAVAFGSNNNSSNQQSLQSLQQQQQHVVHQHQHQPLPADEPIPKTNLIIFQQIINALLPKLQLNGFDPNLQFDLNKFQKVVQYVMSKSQTFTLNLNEITELMQDPDSQIPPPPPASSSSSHHRRTLSVGSFDDSSNSAVSSPREVGLHLPSKEVALNLIYTTWNKACVLFRFYHRPSLLEEVDLLYSLDPMNYGDRQQKFLPFLYSILACGSLFSKTPYTMGTPSENEKNLEDDGFKYFLEARKLIDISNVGDINSIQTVVMMIIYLQCSARLSTCYSYIGIALRSALKEGLHRNLTLFQNSKKKLDPIEEDTRKRLFYTIYKMDIYINSLLGLPRSLNEDEFDQLLPVELDDENVTRTEYLFDKQQGRLSSSGCANQHTKLMFILSHIIKKMYPIKVKPEEAENSSNVNYSRDRIHAKVTELEVELKNWLDNLPQELKPIDPSSTTKDVIDEVPEKFRLANYYLHLAFLNCQIILYRPFIHFISDSMDGSSSDPRSLIRGRNCIKVARMVVKLANKMIDHKLLLGTYWFSMYTIFFSIACLIYYFHFANYNNNGQGFNYAGILFDDDLNIDMIKKDIEIGKKVLDNLKNSSNSSLRIYNILNTMFEQLNRRTASRSRQVTATTNSTTTTANTNSNSNSNSQPTTLPANFQNVNVKNTFENFDNMNHFVKKERERERESLSQLFDNTSMAKFESSSEIPKNVANIQRVATPLEENNKEIGEVSGGNLTSNYMPGVFDKLDTQIFGKILPPYMLEKNETMNYNSNNNNSNNVNNNFNNNNNAGEVNNNSNGVAYNNNAANWPLNNAEDGLNLEDLFGTLGNNGNGGTSSSNGLEYLDPF
The following text describes a protein:
Function:
May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Sequence:
MKMNGCNTDCLEKPLSRGFGSLGRLIARYPWWFIVVPVVLSIGSGVGFCFLEQRQIMMFENEFPSPGSLLKREGDFIRTHFPMNNTEHLSTRQLYNEGSFASIIIVSLSQNLLNKSKYEELQRLDAAVRSLSLGSEIHFQSLCALINGSTCFSANPLLDLIQNGTIRTNITYPMFQNRVFLGKYIGGVTLGPDNTVLRAQALRFVYYLREDTEQQLVNNTKWLNNFIASFPQHLQMLQLKSVQVKKSCFFLVQFPPQCLSPVSPALIEHFLQKLVGPHADIFCKKFFVFFLRWAGLQEQYYLFIFVYYYTSVSLQKQLEEDAKRAMPFFSVTFIVTILFSVLSCVRCHNVRNKIWVALFGVISPGLAILTSFGLLLMCGAPFAITAVNAPFLILGAGVDNMFIIISCWQQTKMRATLEERMAETYQEAAVSITITTLTDVLAFYIGIMTHFPSVQSFCIYAGTALVFCYVYCITFFGAVLALNGKLENDNRHWFICVKVNDTEESGQNTMYQMCCLGGSFETSEGIEIEHPVTVFFHKYYGVFLTNQWTKLLTVVVYLGYLAISIYGCFKLQGGVDIQKFPNDNSYLSQYYTNEALYFAGYGPRVMVVVTSEIAYWEPQTSKEIESCMQKLENNSYVDKKFTESWLRTYEHMSKALNVSIITKDGFMNNLDIIFAYFAEFKQDIDKEGNKIKASRFFVQTINVVGAIDERNMATQLRGIAASCNIPLFVYHPIFICLDRYALIIQSAVQNMIVAFVVMLVVSLLFIPNPLCSLWVTFAIASIIVGVAGFMAFWRVNLDSISLITLVICIGFSVDFSSHIAYACFSSKKEKTEERVIDALHVLGYPIVQGALSTILGVVALSVAESYIFKTFFKLTCLVIAFGVLHGLVFIPVFLTIIACPRWSHVSKVKPLKISHQPANIMTELERQRENPIRSVQKDNLSGYSCSMPDVLSTSIPFTTCYYMGWKAGVFSIFHSEKFPQEK
The following text describes a protein:
Function:
Involved in meiosis and required for ascospore formation. Involved in substrate recognition in ubiquitin-dependent degradation.
Subcellular Localization:
Cytoplasm. Note=In the cytoplasm of ascogenous cells. Within these cells, defined areas that resembled immature ascospores were excluded from the staining.
Sequence:
MARSRQPTRFSSEAPSESSSSTSPERAADDDTDFFTLQANDSQSSIGAGNPRDSHIQNDPETVLPPIAYLPPEILISIFSKLSSPRDLLSCLLVCRIWALNCVGLLWHRPSCNNWDNLKKIAAAVGEEDSFFLYSSLIKRLNLSALTEDVSDGTVVPFSQCNRIERLTLTNCRKLTDIGVSDLVVGSRHLQALDVSELRSLTDHTLFKVAENCNRLQGLNITGCVKVTDDSLIAVSQNCRLLKRLKLNGVSQVTDKAILSFAQNCPSILEIDLQECKLVTNQSVTALMTTLQNLRELRLAHCTEIDDSAFLDLPRHIQMTSLRILDLTACENIRDEAVERIVSSAPRLRNLVLAKCKFITDRAVWAICKLGKNLHYVHLGHCSNINDSAVIQLVKSCNRIRYIDLACCSRLTDRSVQQLATLPKLRRIGLVKCQLITDASILALARPAQDHSVPCSSLERVHLSYCVNLTMVGIHALLNSCPRLTHLSLTGVAAFLREELTVFCREAPPEFTRQQREVFCVFSGEGVNRLRNHLNREAAPQRDANEATMYDDEEELDEDEGQVTGLMHAAAINDDDYINITPPHA
The following text describes a protein:
Function:
Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
Subcellular Localization:
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Sequence:
METTYRREALTVRVIFCTSGDSAETIADVLTGAPTSASFFSVLHDLFYSQILAPRVTLKLCLPARRPGNGTRCSPVLVLRTDASVASGFLGGRPLEASDIKYMLLSDQTAGLFKPLLEIIGGARAPPNQDACTFQSQVAWLRTKFVTALRKLYKMTPSPYWMLSAFGAQEAQFVLTSSFYFFEHTVVCTTETVSHLSRLFSPQQGQTLVSVTSHEELGQLYGTSPFRRRVPAFVAYVKEKLARDSLETEAIDRTIDQIRGKLMLSNQDLVHFIYISFYQCLNKRAFLRYSRQTSSSSALRELGEDPQLCGALHGEFRDHVQSYYHKKTYLSTYIDIRYVGGVLPDGYFGGSLVGERCVYWCGQSKDTASLLATISQQVPHLRLQNEFAGMLDVAALRGSDDGQFKEGLFSHSQALPLYRCEFLGKQFFTMLQEDGLERYWEQSVIFPGDQDWDMLSDKDLTYRIFYHDLSLSLPTLKEQLLVSRHEYFNPRLPVYRWVLDFDLPVCRDIDRTFEEVHSLCCSLREAILDIIQLLGPVDPRTHPVYFFKSACPPDEWRGEDVASTSFCRCHDKLGMRIIVPFPEGVCVVGSEPMVALTGILNRTIKLDPELVHRFPSIQKKGGPFDCGIYGRGRSVRLPHCYKVGLVGELCRLLKILVCHPAPNGKAQYVRRAFTLRELLHHSPGHSAGHVGRIIYSIMDRNENFLENKTISYLPAKIPHIFQRIETLSGRSIEDWLHSAVWDKAYDTICKFFPDEKAQQFSHVAFTQQGENIIQLRPRQGRHFLCINHNHKNKSKTVRVFLTLHSIRVSEVTVTLMSQCFASKCNNNVPTAHFSFVVPVGLAS
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus. Cell projection, cilium.
Sequence:
MTATDYHCYSEFFQRQVLACFLTNPHYGSLINADGHAEVWTDWNDMSKFFQYGWRCNTNEDAYSNRTLMGNWNQERYDLKNIVQPKPLPSQFGHYFETTYDTSYNNRRPLSTHRFKREPHWFPGHQPELVPPPYKCTEKSTYMTSYSKPQTDHHSVCVWNPSNCQFQSP
The following text describes a protein:
Function:
The rat seminal vesicle contains six major androgen-dependent secretory proteins referred to as SVS I-VI. The SVS I-III proteins appear to be components of the rat copulatory plug, with the SVS II protein being the major component.
Sequence:
MKSSVFILSLFLLLERQAAVVGQYGGTKGHFQSSSSGFMLGQKGHLNFGLKGGSEEAAEESIFMQSQHQMFGQDGGDMAQTSVSQEHTGVKGAAICRKGQVSQLKSQESQIKSFRQVKSSGQLKSGGSQLKSFGQVKSSESQLKSFGQVKASGSQLKSFGQVKASGSQLKSYGQMKSSGSQVKSFGQMKSSGSQVKSFGQMKASESQIKSFGQRKSQGGQLQSYGQMKSYGQTKSLESQAKSFGQVKSQSGQMKSSYGQRKSYGEETQLKSFDQDAQLKSYGQQKSQKQSSFSQVKSQSAQLKSFGQQKSLKGFSQQTQQKGFAMDEDLSQVRKQFDDDDLSVQQKSTQQMKTEEDLSQFGQQRQFGQERSQSYKGYLAQYRKKLQEQQQQKNFNQDNFFTKGGAGLYQAQLKG
The following text describes a protein:
Function:
Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth. The extracellular domain serves as a sensor for peptides derived from GRI. May act as a downstream element for ROS-dependent cell death induced by GRI.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain may be catalytically impaired due to the lack of the conserved Asp active site at position 500, which is replaced by a His residue.
Sequence:
MRNWEDPFTLACNTALKKNLPSCIFIIIFISVLCPVAMSQVVVPDSDADCLLRFKDTLANGSEFRSWDPLSSPCQGNTANWFGVLCSNYVWGLQLEGMGLTGKLNLDPLVPMKNLRTISFMNNNFNGPMPQVKRFTSLKSLYLSNNRFSGEIPADAFLGMPLLKKILLANNAFRGTIPSSLASLPMLLELRLNGNQFQGQIPSFQQKDLKLASFENNDLDGPIPESLRNMDPGSFAGNKGLCDAPLSPCSSSSPGVPVVPVSPVDPKSTSPPTGKKAGSFYTLAIILIVIGIILVIIALVFCFVQSRRRNFLSAYPSSAGKERIESYNYHQSTNKNNKPAESVNHTRRGSMPDPGGRLLFVRDDIQRFDLQDLLRASAEVLGSGTFGASYKAAISSGQTLVVKRYKHMNNVGRDEFHEHMRRLGRLNHPNILPLVAYYYRREEKLLVTEFMPNSSLASHLHANNSAGLDWITRLKIIKGVAKGLSYLFDELPTLTIPHGHMKSSNIVLDDSFEPLLTDYALRPMMSSEHAHNFMTAYKSPEYRPSKGQIITKKTDVWCFGVLILEVLTGRFPENYLTQGYDSNMSLVTWVNDMVKEKKTGDVFDKEMKGKKNCKAEMINLLKIGLRCCEEEEERRMDMREVVEMVEMLREGESEDDFGSMDHRGTHNNVYSSMLLDDDDFGFSMNR
The following text describes a protein:
Function:
Antimicrobial peptide.
Subcellular Localization:
Secreted.
Sequence:
GILDSLKNLAKNAAQILLNKASCKLSGQC
The following text describes a protein:
Function:
Involved in regulation of the quinolone signal (PQS) system and of pyocyanine production. Negatively regulates the quorum-sensing response regulator pqsR of the PQS system by binding to its promoter region.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGHSKWANIKHRKERQDAKKGKIFTKLIRELTVAARQGGGVPADNPRLRLAVDKALTANMTRDTIDRAIARGVGSNDADNMVELSYEGYAPSGVAIIVEAMTDNRNRTAAEVRHAFSKCGGNLGTDGSVAYMFERKGQISFAPGVDEEALMDAALEAGADDVVVNDDGSIDVFTTFADFISVNEALAAAGFKGDEAEVTMIPSTTATLDLETAQKVLKLIDMLEDLDDVQNVYSNADIPDDVMAQLG
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MAASAEAEVSQSKPSPLKDQAGPVQPRPAGLTPGNPVQAVVEEAASPCASSPQAPSSAPNSHRRPVGGRIGRVHLGQPGRRVPDEEDVEAIPGGSRELGITEDWFDVPPLFPPVDTTQTHLAILSPNPKGPPMLYQWPFTHMTDSSYDAGFELLNSMNHIVKLCALPVPDTWADDIVACAKPGTEFASLSKVVEAFNAAMRVYHKSVGEQAERLICPTDLCEHIMNMTYSRAVTDPALLNRYKGWTAEVYGEFTSKMISDVIANSNVQPDDTFVDLGSGVGQVVLQVALEGRARTSFGIEKQDIPAEYAKCGAYELVKDNFLQPQYAERITNTSVVFLNNFAFGTKVNQQLCRMFENCQAGTRLISSISLRKSDFTITARTLNDLGCILTMRKLCYRGQGVSWTARPFSYYVQTVNHQYLDQFFSKGEPVQVPFENEVGDDDDDANPDRTGTSHSGAPVRDNSDDEEDNDEEAEDQSAGAAGHHKTDAVGKGHSGAERDGKAAAGTRPGSTKRSKGASRRRDRQSSQQSSAPPSSSSGKVAAGDDSASQRLVRTLTRAVAGLERRYPSGRTLRAARHQLRALHQERSVLRQHRREYEQQLQQHNQTVAAALTQRRQQLNESLGLDSKTDTRLTAAAAGLLHTFVCRGGQSATSSAANAQQSVEHIRLWTKPLQQAQAVHERLIAALRMHGQAPVADALQRTPWALPRDLCASNEHSPTRATNGHVPVQEASAGKAGPTGPHQSARRSSDQNGSASSQVQSAQTRGLEATPDRYAGPLSSAETSPASTSSHSAGKRDLSGQREATNGTEHTSQAQIAGRRESSSTGTSPTSSLAKLLGAEPSHRSGHRQGQQRPIARAREMRPPGGARPGLSSSSKRPLSSNGEPAPQVPDPKRTKDLENASSDNALERKQKCHGPETSN
The following text describes a protein:
Function:
Required for centriole duplication likely through its interaction with Sas-6. During embryogenesis, maternally provided protein is required for centrosome duplication and nuclear division cycles of the syncytial embryos. In femoral chordotonal organs, required for sensory cilia structural integrity and functionality necessary for motor coordination. In male germline, has a role in cytokinesis which seems dependent on its localization to the Golgi.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus, trans-Golgi network. Note=Co-localizes with the centriole in interphase and mitosis. Mostly found in the Golgi, with a small amount detected in centrosomes. In spermatocytes, localizes to the trans-Golgi and inside the Golgi cisternae.
Sequence:
MTEKFNGFSHDEILKITGVKEGGVGKRPASLEAAKPALRIQPGIRRMPDKIFRQADQLRKQQQQQPQQPIQKPDVAKKTKSGTATPTEKPPTPTPAAEDDVANGSLNLDRPLSDSLIEALYHGNATARDKKTPATYADAETTSTDDSSILKISGGDSQTTSSTDDGSILPSTQDTSPRERLNTDSPFKGISLKDFEQHRRMIEEQNKQKKQMLYQAIEQHTQKTAAESRKIEEIRHELSKLESDLAVDVALLRKQIDNACIHFANVEKQYVKIEAQFLRAKIELHNASEKKELLTEHLCTVIAHNEDRKAQKLTELMQKVGLSPTDDCQPIDLTQQSP
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MMTNGVVHANLFGIKDWVTPYKIAVLVLLNEMGRTGEGAVSLVERRKLNQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMDREDGEKQMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQAALLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAEGKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRADSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLESLNAGVQQNNTESFAVALCHLAELHAEQGCFAAAGEVLKHLKDRFPPNSQHAQLWMLCDQKIQFDRAMNDGKFHLADSLVTGITALNGIEGVYRKAVVLQAQNQMTEAHKLLQKLLTYCQKLKNTEMVISVLLSVAELYWRSSSPTIAMPVLLEALALSKEYRLQYLASETVLNLAYAQLILGIPEQALTLLHMAIEPILADGAVLDKGRAMFLVSKCQVASAASYDPVKKAEALEAAIQNLSEAKNYFAQVDCRERIRDVAYFQARLYHALGKTQERNHCAMIFRQLHQELPAHGVPLINHL