lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Negative regulator of T-cell proliferation.
Miscellaneous:
MISCELLANEOUS: [Isoform 8]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Membrane; Single-pass type II membrane protein. Note=Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.
Sequence:
MVDFPGYNLSGAVASFLFILLTMKQSEDFRVIGPAHPILAGVGEDALLTCQLLPKRTTMHVEVRWYRSEPSTPVFVHRDGVEVTEMQMEEYRGWVEWIENGIAKGNVALKIHNIQPSDNGQYWCHFQDGNYCGETSLLLKVAGLGSAPSIHMEGPGESGVQLVCTARGWFPEPQVYWEDIRGEKLLAVSEHRIQDKDGLFYAEATLVVRNASAESVSCLVHNPVLTEEKGSVISLPEKLQTELASLKVNGPSQPILVRVGEDIQLTCYLSPKANAQSMEVRWDRSHRYPAVHVYMDGDHVAGEQMAEYRGRTVLVSDAIDEGRLTLQILSARPSDDGQYRCLFEKDDVYQEASLDLKVVSLGSSPLITVEGQEDGEMQPMCSSDGWFPQPHVPWRDMEGKTIPSSSQALTQGSHGLFHVQTLLRVTNISAVDVTCSISIPFLGEEKIATFSLSESRMTFLWKTLLVWGLLLAVAVGLPRKRS
The following text describes a protein:
Function:
Involved in the synthesis of fatty acids. Elongates arachidonate and other C20 polyunsaturated fatty acids (PUFAs) with a preference for n-6 PUFAs. Not involved in fatty acid synthesis up to C18.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMDCRDASACQGVGSLCFFPYLNPLVSWHALVLGHLLYLFVVFVMRSIMRGRRALNMSRVLVVYNVLQICLSAAMAINLSPPLKNGVFNLSGKFCPDIEFWMFVHYCSKYIDMLDTVFILCKKKEDQLSFLHVYHHCTIGLIWGILLRNGLANGTAFFGTWINSSVHFLMYSHYLWTSLGYRNPFKFLLTKIQMLQFSLCILHAILVTLLDTQFTLGWNLLQLLYNASLLVLFLNFYMNSRGKGCAIEKKPQ
The following text describes a protein:
Function:
Chaperone of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells, facilitating the establishment and dissemination of infection. Along with PscE, prevents premature polymerization of the PscF/SctF needle protein within the cytoplasm. Required for type III secretion needle assembly. Also required for cytotoxicity by influencing PscF/SctF levels.
Subcellular Localization:
Cytoplasm.
Sequence:
MDTSLIRELAELALAGSGQHCHEEALCIAEWLERLGQDEAARLIRISSLANQGRYQEALAFAHGNPWPALEPWFALCEWHLGLGAALDRRLAGLGGSSDPALADFAAGMRAQVRT
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MAVITCFRPLVTPTGLQWRQRGDSSRRLRTSLSAPFGLHALLLLPLLLCACSGHCPAATGLKLVARHTAAAAQSQSPAAAEGQAAAMAQRAALRGAALRGAVPGTAVAPRTAVATRTAVAARQLPERPGRGAGTTAAQAHHGSSGGGSSSSSHVSTGGGGASRGRQLGGMRWEACGGGPAGAPMLQPDDVSMAPDPPHHGRTMDINVTGTTPLSTPGGRFQVAVSYLGVRVYTHATDLCDAMPCPLEAGTPFRLRVSQKLPMLAPPGPYTMEITGDAEAGGRFMCVLISFNLAAPGGSPAAEGPAGGHS
The following text describes a protein:
Function:
Part of the PpsABCDE complex involved in the biosynthesis of the lipid core common to phthiocerols and phenolphthiocerols by successive additions of malonyl-CoA or methylmalonyl-CoA extender units. PpsA can accept as substrate the activated forms of either icosanoyl (C20), docosanoyl (C22) or lignoceroyl (C24) groups from FadD26, or a (4-hydroxyphenyl)-C17 or (4-hydroxyphenyl)-C19 fatty acyl from FadD29. PpsA initiates the biosynthesis and extends its substrate using a malonyl-CoA extender unit. The PpsB and PpsC proteins add the second and third malonyl-CoA extender units. PpsD adds an (R)-methylmalonyl unit and PpsE adds a second (R)-methylmalonyl unit. The incorporation of the methylmalonyl units results in formation of two branched methyl groups in the elongated product.
Sequence:
MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLSGELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGARNSLDEPIAVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQRWQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQRLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLSQVDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGAGVVVLKRLTDAQRDGDRVLAVICGSAVNQDGRSNGLMAPNPAAQMAVLRAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLLIGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDLRMKVVDTQTEWPATGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPGQGLSPAVSTLVVAGKTMQRVSATAGMLADWMEGPGADVALADVAHTLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVNPAEGSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVLANGEELVGIEQIQLGLIGMQLALTELWCSYGVRPDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIADFPQVTLGIYNSPRQTVIAGPTEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQPVFDAEHWATNMRNPVHFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSAQPGARYTSLGTLQRDTDDVVTFRTNLNKAHTIHPPHTPHPPEPHPPIPTTPWQHTRHWITTKYPAGSVGSAPRAGTLLGQHTTVATVSASPPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAATELGYSALSEVRFEQPIFADRPRLIQVVADNRAISLASSPAAGTPSDRWTRHVTAQLSSSPSDSASSLNEHHRANGQPPERAHRDLIPDLAELLAMRGIDGLPFSWTVASWTQHSSNLTVAIDLPEALPEGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGPRSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRAQPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIGDDSAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAVRICTEITGLVRTLAERDADKPAALWILTRGVHESVAPSALRQSFLWGLAGVIAAEHPELWGGLVDLAINDDLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEPARKSLQCRPDAAYLITGGLGALGLLMADWLADRGAHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEAVAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVRQVMWPKIGGSQVLHDAFPPGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALARARRQQGCHTMSLDWVAWRGLGLAADAQLVSEELARMGSRDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADGSGANAYLLPARNWSVMAATEVRSELEQGLRRIIAAELRVPEKELDTDRPFAELGLNSLMAMAIRREAEQFVGIELSATMLFNHPTVKSLASYLAKRVAPHDVSQDNQISALSSSAGSVLDSLFDRIESAPPEAERSV
The following text describes a protein:
Function:
Catalyzes the decarboxylation of D-ornithine and D-lysine. Ornithine is likely the physiological substrate. Has no detectable diaminopimelate decarboxylase activity in vitro.
Sequence:
MTDSIMQNYNQLREQVINGDRRFQHKDGHLCFEGVDLDALARQYPTPFYVFSEPEIIRNIHEIQQAFAAHKNTKTFFASKTCSVMGVLKAIRDAGICAEANSQYEVRKCLEIGFRGDQIVFNGVVKKPADLEYAIANDLYLINVDSLYELEHIDAISRKLKKVANVCVRVEPNVPSATHAELVTAFHAKSGLDLEQAEETCRRILAMPYVHLRGLHMHVGDQVPESEPFAKATKVLVDESRRLEEVLGIKFDLINVGGGIPVPYKYDDENGDPLKDNMYAGITAQDFADAVIREVHKWRTDVEICIEPGRKVTGSAAVLLTEVSCEKRKTNYDLNGNVECHVEWKFVDAGYSVLSDSQHFDWFFYVYNASRMTAAHDAWIKLAGPLCDGGDYFHMGVKGEEFLLPKETHVGDIVAFLDAGAYTIESQTVYNNRPRTGVVMIDKNGDTRLIRREDSYEDMVKYDIY
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKLTVKTLKGSHFEIKVQPTDTVMGVKKNIEDVQGKDNYPCGQQLLIHNGKVLKDETTLVDNKVTEDGFLVVMLSKSKTAAAGTSSTQPVSTPPTTTPTSNSTPDAPAPDAQAPASKSASASDTATANAQSDTYGQAASNLVAGSSLEQTIQQIMDIGGGNWDKETVTRALRAAYNNPERAVDYLYSGIPETAEVAVPVARFPADQGIETGAAPAAPALAPGGPNSSPLNMFPETLSGGGGDAGLVLGSLDFLRNNQQFQALRSMVQANPQILQPMLQELGKQNPQLLRMIQEHNAEFLQLINEPLDGSEGDIFDQPDQDMPHAINVTPAEQEAIERLVAMGFDRALVIEAFLACDRNEELAANYLLENGADFED
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Sequence:
MVSKDLPFTKEEILKITEKYPTPFHIYDEKAIRENARRMKSAFKDVPGFKEFFAVKALPNPFILKILKEEGFGADCSSLPELILAEKAGMTGDDIMFSSNDTPAEEFAKAKELGGFINLDDISHIHYLEKAAGLPEIVCFRYNPGPLKEGNAIIGKPEEAKYGFTREQMFEGYRVLRDKGVKRFGMHTMVASNELNSDYFVETARILFELIVEISKELGIQFEFVNLGGGIGIPYRPEQEPVSLEAVAKGVKEAYNATITANGLAPLKVYLECGRIITGPYGYLVSQVRHLKSTYKDYVGMDSCMSNLMRPGMYGAYHHITVLGKENKPPVHKYDVTGSLCENNDKFAIDRMLPEVEVGDILVIHDTGAHGHAMGFNYNGKLRSAELLLREDGSVVQIRRAETIEDYFATLDFEQLKSFR
The following text describes a protein:
Function:
Required for autophagy.
Subcellular Localization:
Cytoplasm.
Sequence:
MNMSHPDQVELWRSVMSGKLETYNRISSKLKLGIIGDEFSGKPNLSPLKGQQGVNDTEATAARKASRVPVRLYLWIVDKDFDDLEEAPNFDRWDQVSYINRPVEFYTEGKYFTLLDAVKSILPEFYPGSLNTTKAESKDEPGTEPENESHPVIKLLRIQGIEPKMEIPFSWVVNNLMNPDYFLHICLYIKPPKPIGT
The following text describes a protein:
Function:
Involved in transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSMLGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVPLYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLFSIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGMLTYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLYSVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVCTWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLSWQPIAKKTKV
The following text describes a protein:
Function:
Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLTDKTEGDGESEKTQTNISQWPVDCNDQLDGSCSSSQGRGPSQQNGNKDNSMDMLGTDIWAANTFDSFRCGKGKLEDGEGINLNDIEKVLPAWQGYHPMPHEAEIAHTKKLFRRRRNDRRRQQRPPGGNKSQQHSDHQPGSAKHNRDHQKSYQGGQAPHPSGRPNHHGYSQNRRWHHNNPKHPPGDKEAATHRNNAKETESLKIEDAPVCTVHIPLDMHRNPDASPTERPPPQQPGGLEVEAKRKDSVLNDRIGERPKIKLLQSSKDRLRRRLKEKVPEEIPVVPPNPQRNKMDKLIEILNSMRNNSSDVDAQLTTFMEEAQNSTNSEEMLGEIVRTIYQKAVTDRSFAFTAAKLCDKMALFMVEGTKFRSLLLNVLQKDFTMREELQHKDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQSQDVKEDAVLCCSMELQSTGRLLEEQLPEMMTELLASARDKMLCPSESMLTRSLLLEVIELHANNWNPLTPTITQYYNKTIQKLTA
The following text describes a protein:
Function:
May play a regulatory role in sulfomenaquinone (SMK) biosynthesis. Not essential for SMK biosynthesis.
Sequence:
MANDARPLARLANCRVGDQSSATHAYTVGPVLGVPPTGGVDLRYGGRAGIGRSETVTDHGAVGRRYHQPCAGQIRLSELRVTILLRCETLCETAQLLRCPPLPCDCSTPL
The following text describes a protein:
Function:
As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MPRRKQEQPKRLPSHVSRQEEAEGELSEGEHWYGNSSETPSEASFGEVQENYKLSLEDRIQEQSTSPDTSLGSTTPSSHTLELVALDGEVLRDSLQCQDHLSPGVSSLCDDDPGSNKPLSSNLRRLLEAGSLKLDAAATANGRVESPVNVGSNLSFSPPSHHAQQLSVLARKLAEKQEQNDQYTPSNRFIWNQGKWLPNSTTTCSLSPDSAILKLKAAANAVLQDKSLTRTEETMRFESFSSPFSSQSASSTLAALSKKVSERSLTPGQEHPPPASSFLSLASMTSSAALLKEVAARAAGSLLAEKSSLLPEDPLPPPPSEKKPEKVSPPPPPPPPPPPPPPPQSLELLLLPVPKGRVSKPSNSASEEESGKPFQCPICGLVIKRKSYWKRHMVIHTGLKSHQCPLCPFRCARKDNLKSHMKVHQHQDRGETFQCQLCPFTSSRHFSLKLHMRCHQHFLRTEAKVKEEIPDPDVKGSPHLSDSACLGQQREGGGTELVGTMMTSNTPERTSQGGAGVSPLLVKEEPKEDNGLPTSFTLNAADRPANHTKLKDPSEYVANSASALFSQDISVKMASDFLMKLSAANQKEPMNLNFKVKEEPKEGESLSTTLPRSSYVFSPESEVSAPGVSEDALKPQEGKGNVLRRDVSVKAASELLMKLSAESYKETQMVKIKEEPMEVDIQDSHVSISPSRNVGYSTLIGREKTEPLQKMPEGRVPPERNLFSQDISVKMASELLFQLSEKVSKEHNHTKENTIRTTTSPFFSEDTFRQSPFTSNSKELLPSESVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLHTEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSICCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGFECVFCNFVCKTKNMFERHLQIHLITRMFECDVCHKFMKTPEQLLEHKKCHTVPTGGLKCPFCIYSTNRPAAMECHLKTHYKMEYKCRICQTVKANQLELETHTREHRLGNHYKCDQCGYLSKTANKLIEHVRVHTGERPFHCDQCSYSCKRKDNLNLHKKLKHAPRQTFSCEECLFKTTHPFVFSRHVKKHQSGDCPEEDKKGLCPAPKEPAGPGAPLLVVGSSRNLLSPLSVMSASQALQTVALTAAQGSSSEPNLALKALAFNGSPLRFDKYRNSDFAHLIPLTMLYPKNHLDLTFHPPRPQTAPPSIPSPKHSFLAYLGLRERAETV
The following text describes a protein:
Function:
Ligand for the neuropeptide SIFamide receptor. Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination. Also involved in promoting sleep.
Subcellular Localization:
Secreted.
Sequence:
MALRFTLTLLLVTILVAAILLGSSEAAYRKPPFNGSIFGKRNSLDYDSAKMSAVCEVAMEACPMWFPQNDSK
The following text describes a protein:
Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.
Sequence:
MSANESNETSSVSSNCHASTPKESEKGKKDPKRTPLSHLKKVHCSFKSPHHVTEKAKVSHEGEVAELQRRREQLDSEIEQLEAEGYKVEELEHHIKKLHEYNDIKDIGQSLLGRIAALRGTTTRDLYTQFDLALDD
The following text describes a protein:
Function:
Essential for the onset of septum formation. Involved in the organization of astral microtubules during mitosis. Acts as a bridge between sid4 and the other SIN proteins mediating their association with the spindle pole body (SPB). The sid4-cdc11 complex organizes a signaling hub on the SPB which coordinates cell and nuclear division.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes at the spindle pole body and the barrier septum.
Sequence:
MEQLWLEHDLSEEWIPQPQEQGSDNSSEPPTTSNVNNTQSTGRGSSGTSTEHGTFKKGRNDAPDVPQWKQVNAKNPVARDIFARLDLENMFEESSKQSPPSKSPTKNPSKKSSNNSSRRSSSSVGKLSNVSNMQSSPSKDPFVSQDYEKESISSSQFSKKYSEGSLKSQQSNTRSNSVHEKQNTDHASNASSSSSVVSSPSLKPNNTSPLKLFQGASDPFTREHLNQLTQDVKSNSFENGEKQFSLPEPRRPQKPMRTTERKASLNTKDLYQEVEEVMARLRGRMPNSGRESTIFLPRKLSGLREEEEQDEISVEVSQEDSSNAFPSLSDQLHLKSLQSMKRVTSIFNDNDDSFPSASSSPQRQAYMTDKMPLREIDVGSSQSSSKTARLNSSPKSTLKTSSVKTRRSHSAQSSRKVSDYPNMVVITPADLPEGIDTTQGSMEFDRIHNRWRRKGHDSDLGFDFETDEDASLSHPERTILFKAASTRHQANNDPNNLEKQQPHSFPLRKQNVAQSEFPKHSLRDNSENAPQILSSFHDLSLQNESFDEMFNGRYENGSPIPFISSGSGLKSKADKDAEYSFSVSRQSIIQILSDVEPYEPFWKRIIQLDISRRHLDSLIGLSELCPSIEELTLEGNEIAYLTGCPVTIRDLNAVENRLSSLTSFSNLLNLQYLDISYNQLEDLTGLSSLIHLRELKVDSNHLWSLDGIQHLDGLLKLSACNNRIKELSFTNSNLHRLEELLLGNNEIEEIEEISSLQNLMVLQLDNNKLTNLKASQPMIHLRILRISNNAIHQLEVDQFPHLRTLYMDLNRFNRPPDIRRLKRLVNFSFRTQDPEASNFVIQPSLDIRNLYLSNNTFVTLDCKHMFLGVRYLELANVQLKEVPKYIATSMPNLRVLDLSHNYISDIESLKPLQMIHRLYLVGNRIKKMRNLCDILANLKQLNVLDLRMNPLNFNIYPVIDDSIYELSAASKYQQSINQKGHHRKEDPQKQWQEKELAFSSTLSEAWRTRRKMYAEAILLACPHLEWLDGSDVSQSSRAAFTKSSN
The following text describes a protein:
Function:
Required for sporozoite development in the mosquito vector. Required for parasite transmission to the mammalian host.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Note=Localizes to vesicle-like structures in the cytoplasm of gametocytes, ookinetes and midgut sporozoites. The number of the vesicle-like structures varies between individual parasites and lifecycle stages.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop (By similarity). One of the two canonical Asn-Pro-Ala (NPA) motifs in the pore region, which are highly conserved in aquaporin water channels, is changed to Asn-Pro-Met (NPM).
Sequence:
MKTKGRLLLYINYAKYAIKACFKIIINHIKDIREEINVKSFSKYKYNFLFEFIGSFIFVFLISVYMLNSNQNEEYIIKHLNQINPYKKNDIFINEVNIHNNDINGSEDIRNASGIKNINSINDVKMYEARALLNQGNKQLKEQNDTIFEKNKINNTEKIENSISEEKEQTIPNTNEDSTTIVNDNKREEDEVTNIGEKNDKINEAAYIISLPKDSNKEKLTKDIDEVIFKDKVNEYSKIKLDDINNMDLKKFDDIKILKDSSNKNNSNHAIYSFFGCLIYVLFIILGAHINPAYTYALWLIEPQKYGFVITTLYATFQYIGGILASILCAHIYGSIFIYSLLPRKHIMKTFLCEFVSTFLLTILLLSFYNYKKLFKEENQNEEEFSFNKEKIKNMSSLYSSHSFEDIYEYDIFSTYSTNSTNNNKYKKLFIYFDNKYIKYIINHIFYLLFIFFSLLFFVFVTNTTLNPMFSTSTLCTYLYFKYVQSNNSFNFFSIFFSFLSLGKIIQIIIFYIKSLPLWIGPYAGSACATFFMKLFKDNNEEIVNVIDTNVYSHNRTKEKMPLINTNNMNHNAYLEEYNDHICYNSNNYLNYKIF
The following text describes a protein:
Function:
Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MDMNGENYVLTVDIGTTTIRSVLYDSSCTERGSYQEKVNTIYSTGNDDEVLVEIDPEHMFRQFVRVIEKVYKTLPPNAHVNIGLCTQRNSIVLWNKKTKKEETRIICWNDKRANKTCHQLNNSVILKVLNIVGGFLHMVTRKNRFLAAQRLKFLGAMVSHRLIVTINRSEKLRRMKADGDLCFGSLETWLLMRSSKSNELCVEASNVSPSGMFDPWIGAYNVLIMKIIGFPTDMLSRIVDSNLSDMEKLPILDRTHVGSELSISSIIADQQAAMFGCGTWERGDVKITLGTGTFVNVHTGTIPYASMSGLYPIVGWRINGQTDFVAEGNAHDTAVILHWAQSIGLFDDVTETSDIAESVENANGVVFVPAFCGIQTPVNDETACSGFLCIRPDTSKVHMVRAVLESIAFRVYQIYTAAEKEVYINKNSPVRICGGVSNNNFICQCIANLLGRPIERMADSDHVAARGTAMLAGYSQGLWTKQDLKKLVKIERTFTPNLESRKGLLKSFETWRKAVDRCLGFYQ
The following text describes a protein:
Function:
Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.
Sequence:
MSALFRARRAVVLCLAGSRTLSQLAELPETHQLLRQTCRDFANRELIPVASKLDREHAYPAQQIRELGAMGVMAMEVPEELGGAGMDYLAYSVAMEEISRGCASTGVVVSVNNSLYIGPVLKFGTEEQKKKWITPFTTGEKVGCFALSEPGNGSDAGAASTTARQEGDEWVLNGTKAWITNSWDASATVVFATTDKKLKHKGISAFLVPMPHPGLSLGKKEDKLGIRASSTANIILEECRVPLDSMLGPRGAGFKIAMQTLDSGRIGIAAQALGIAQASLDCAADYAHKRTAFGAPIGKLQAVQFKLADMGVALESARLLTWKAALLRDSKRPFTKEAAMAKLAASEAATFCSHQAIQILGGMGYVTDMPAERHYRDARITEIYEGTSEIQRLVIAGQILKEYQP
The following text describes a protein:
Function:
Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively; Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
Subcellular Localization:
Secreted.
Sequence:
MRMLLHLSVLALGAAYVCALAVESPMNRLVAETLTLLSTHRTLLIGDGNLMIPTPEHKNHQLCIEEVFQGIDTLKNQTVQGDAVAKLFQNLSLIKGYIDLQKKKCGGERWRVKQFLDYLQEFLGVINTEWTTES
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MADKCGNCDCADKTQCVKKGNTYGIVMVDTEKSHFEVQETAENDGKCSCGTSCTCTNCTCGH
The following text describes a protein:
Function:
Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the distal end of centrioles throughout the cell cycle.
Sequence:
MAHRLTKEELDQQFEQFLKESVSDDSVDLGTSSKRPSVLDSLGKAPVRPVKKASASVPWWQDDDDNDDDSEEKGMSSTGRSFLKSLRKTPSIKEVDEEQPKELFLEDEGNRDHVILSRDSLEPEDSLVIPSAGARGLDTLDEDDDDARFLSNLKKVSSSSIDFSRINREQELSAPTSPLRREEMDSTIEEEQRMNKDTAASPAYSEDFEEEASDKSDVEPQEKKPERLGMLAKVSLHDSLNSTDGALAPAVPSLAVARENRPESKQTDMPALEPAVQSYGQSGGSEMEALQEAYRQISGSAGVCEDGQVEAGRTPLSLSTLQPASTVESDLPTAEELMQPIGPDSGFTRGFSLQPITEAVPRSRDNQSPLRISSDESPFSSANEGYGGGNTANLTGGEHPDSYKFTQKSISEEIRRLMQEQDTSSQEPPPLKPKKRQVPARSNASTSASSRKAPVPSVRVKKPESKPLHRVPAPSRAAQAAKPPSPPTLRKAQNQTFKKTQNLNQTHTIKGLDTSLKLSSELVESVQSFAAFLQHQVEASSLQDKGPFQANKIASEAMTAHKGMQEKMDGGPELASLERLRLQLAKKERELSLREDQLQEQHKQELTALRQENYILQSKLHRAEEASNKRKWSFGEASDPVTEEKLKLIEKEMKEQETLIQGYHQENEKLYLQMKALQAQSKQNEEALFMENQRLLTELSFARDRMNTNNIQRTIRERSIVDQSFNIAELTSQVQAAQKKEERLQEEVRRLKQEKQALHVDLEMMRKERDLAKVQAVCKSGDKGFELKLLHDKHREEVTELKKRLQWYAKNQELLDKDAARLHAATAEIQKLTEQVEKLKAEVSRRANEQQRKAKEKAGEAKRIQDLERQLKQKEELLKRRHPNSLPALILAAASTGAEEDRLDVRSLAQSSQTAALLERRVHRLEAELEGRDEAAKRSLRAMEQQYHRIKLQYEQQISDLEQRLSEKSHSYPAISSELIKSHTQTLKAELEEVKEVHQKQVSVLQAEVDSLQEQLRQAQASTQTEKPARSPSRHQLHAEAAQAARIERLTQELNSKSRSIQELTRTIERLQRERRTMLSGPSHERPNNEPKRHLGTAKDTKKPSVETFPPTQDEKDYHPGAFSGTHISEVQLENDSLRTKLEELEVLREKEKVSLQAAVTHAQNQLLRIEEQNAEQLTSVKAEHRKEIEHLLARHALEHSSSRVAELTSQLNTQEIIVQHLQGQVKELQGTKEALAVTKLREETLQNQLSKLLEELKEAKEAHSPELKHFTSLEQKIQSMEFRYSQREKQLQQVIADTRRVVEQEQQSEVERWRKLAQGRAKELEAFRMELDSILDVLRELQRQGVVIPMPEHTSTNTHTYLPLRS
The following text describes a protein:
Function:
May be a glycosyltransferase involved in the transfer of UDP-GalF and UDP-glucose.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MGKSIVVVSAVNFTTGGPFTILKKFLAATNNKENVSFIALVHSAKELKESYPWVKFIEFPEVKGSWLKRLHFEYVVCKKLSKELNATHWICLHDITANVVTKKRYVYCHNPAPFYKGILFREILMEPSFFLFKMLYGLIYKINIKKNTAVFVQQFWMKEKFIKKYSINNIIVSRPEIKLSDKSQLTDDDSQFKNNPSELTIFYPAVPRVFKNYELIISAARKLKEQSNIKFLLTISGTENAYAKYIISLAEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDFPFTRETLGSYEKKAFFDSNNDDMLVKLIIDFKKGNLKKDISDANFIYRNENVLVGFDELVNFITEEH
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MGSASSTQKSRPPSLDDQPRELVRPQAVQNNQNEKLEGLPPMMPLQAVQNNENEIQEGFLPLQAVQNNENEIQEGFLPLQAVQNNENEITHSLTAHNLSGSRGSSISISSDENERQEGLPPMMPLQAVQNNENEIQEGFLPLQAVQNNENERQEGLPPMMPIQAVQNNENERQLVMLRPQAVQNNENEKLEGGSRRVPPRPRRQAVQNNENEKLVAKSQHVPPRPRRQAVQNNQNEKKEADTAKKGGQKALSRLDSSSEFGQDVMISYSHQDMDFMRKMRGSLEASGISVWVDEQGLGAGVDFLNKIGHAIVEAKVFLSLLSPNSVTSKYCKDELALAYISNKPIFPVAMATRDSLRKNMDFGMQLTLAPMEWVDFSDRDSFDVSFAALVHKFIAATKAGDESKAPPSKAKPKLERPKTRQNLNKMTRLNSNPMDDESDFWERAFKDAKDVPWSKFIEAFDSNYSSLLDGMQISSDSEHKDWLMTVLKREMTVDNNVLSRESYDEFCFVGGVKLPFWQRVHEQAVESYTMREVFQMDSSVRLSAIEDLAKYRSKAVVDALLDLLNDTDPNVRAVAAVTLAKSGNAEDQEVIKRLLKTLQDKDRLVRESGCIALGYLRAKEAVPQLVHLWRNDTISTVREAASVSLEKIGGEEAEKAIHMTKVLSEEIKLLMQQSMQKQT
The following text describes a protein:
Function:
Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity). Appears to lack GlcNAcT I and GlcAT-II activities.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MQSWRRRKSLWLALSASWLLLVLLGGFSLLRLALPPRPRPRASQGWPRWLDAELLQSFSQLGELPEDAVSPPQAPHGGSCNWDACFDTSKCRGDGLKVFVYPAVGPISETHRRILASIEGSRFYTFSPARACLLLLLSLNAQTGECSSMPLQWNRGRNHLVLRLHPAPCPRTFQLGQAMVAEASPTVDSFRPGFDVALPFLPEAHPLRGGAPGQLRQHSPQPGVALLALEEERGGWRTADTGSSACPWDGRCEQDPGPGQTQRQETLPNATFCLISGHRPEAALRFLQALQAGCIPVLLSPRWELPFSEVIDWTKAAIVADERLPLQVLAALQEMSPARVLALRQQTQFLWDAYFSSVEKVIHTTLEVIQDRIFGTSAHPSLLWNSPPGALLALSTFSTSPQDFPFYYLQQGSRPEGRFSALIWVGPPGQPPLKLIQAVAGSQHCAQILVLWSNERPLPSRWLETAVPLTVIDGHRKVSDRFYPYSTIRTDAILSLDARSSLSTSEVDFAFLVWQSFPERMVGFLTSSHFWDEAHGGWGYTAETTNEFSMVLTTAAFYHRYYHTLFTHSLPKALRTLADEAPTCVDVLMNFIVAAVTKLPPIKVPYGKQRQEAAPLAPGGPGPRPKPPAPAPDCINQIAAAFGHMPLLSSRLRLDPVLFKDPVSVQRKKYRSLEKP
The following text describes a protein:
Function:
Required for normal somatic gonad development and for regulation of germline development and proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MKLLKKPAGLKKRKVISKRIKIEKKPSSEDEGSSDEEVPKLDGEGSLDGSEDEDDGTVTVEKGGVKKHKLDLEKLKQSDPEFFKFLQQEDADLLNMEDDGDDDEDDDEDDEDEEEEESDDDEDDEEDDDKTKIKKIRKPKIKSDNSGRLIVDSNVYSYLQQVLVLDDETSTPTNPSDVRMAVDVFVACVARVGADIEAPKYVINEQSIFEAVVRMCFQAMPDILKRLLKAKPEGDKVLFSKTAIKKYQTYVRTYLHAMIVFLNEVQTTEVLIATIKAMTRLVDLYAHFSRMSKLLIKAVVRIWSRKTLECRLPAFVCMNLLVKNYPQHFVPLYKTAYVAFVANSKIVTNETWPLLQFMHRTFAELTILNPEQAYKYAFVYIRQTAVHLRNAMISKGRKDLIFSIYNWQMMQCMYMWVRVIAKAHSVNGAEQIGELVYPLIQVIVGIFKLCNAPTFLPLRLHCCQLLIQLQASCTNYIPILQVSCDCLEELARELKSKPKPVKGAVKLPDIECTLKCSSQFSDLPQWRKVISEHVFRTMMQSAHLLASQAAFPDVVLPINHRISAILETMKNGDHAHLFRGFQTKLKEHSRFVLDVLARKSVDINDEMQVRAVRFDLNNPDSPIKTFYRQWEKVWKMKERSAVENSKKDDKKKKKEEEAAAAKKRKPNETVEDEDDVKPEVSKAKRKRIKIGAAAKKADASVPDQFADMSMWSDED