lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVSLVVVRLEIADQSPPPRGFQYCAVEGMSEEQLQEKALGLAKLSLNGKSELERAAVLHQHIGSRAMGDMVIETFEAADGSARDAHTEPESLGGAEPSPVDSAAKGTAPDSPSKQLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLTEDVRRSAMVCILTVPATMTSHDLMQLMAPFNEVMEHMKIIRDSTPNQYMVLIKFCSQADADSFYTTCNGRQFNSIEEAVCQVVYVERAEVIKSQEGASLPVMELTELPKCTVCLERMDESVNGVLTTLCNHSFHSQCLQRWEDASCPVCRYCQTPEPVEENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGKMVQFECEGDTCQEEKVDGLQLEVCTFCSLVPAESPKSLSTQLSGRVLKLSQELKEEQEMNRCLRANQAQLQAQLAEEERERKDAVIAELQEQLRDVMFYLETQQKIEQLSSEARSEIQDGQIDIPAGPADSAAAGPSSGRGRRGRGRKRK
The following text describes a protein:
Function:
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRCLAARVNYKTLIIICALFTLVTVLLWNKCSSDKAIQFPRRSSSGFRVDGFEKRAAASESNNYMNHVAKQQSEEAFPQEQQKAPPVVGGFNSNVGSKVLGLKYEEIDCLINDEHTIKGRREGNEVFLPFTWVEKYFDVYGKVVQYDGYDRFEFSHSYSKVYAQRAPYHPDGVFMSFEGYNVEVRDRVKCISGVEGVPLSTQWGPQGYFYPIQIAQYGLSHYSKNLTEKPPHIEVYETAEDRDKNKPNDWTVPKGCFMANVADKSRFTNVKQFIAPETSEGVSLQLGNTKDFIISFDLKFLTNGSVSVVLETTEKNQLFTIHYVSNAQLIAFKERDIYYGIGPRTSWSTVTRDLVTDLRKGVGLSNTKAVKPTKIMPKKVVRLIAKGKGFLDNITISTTAHMAAFFAASDWLVRNQDEKGGWPIMVTRKLGEGFKSLEPGWYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNKHDWYEEYPTTPSSFVLNGFMYSLIGLYDLKETAGEKLGKEARSLYERGMESLKAMLPLYDTGSGTIYDLRHFMLGIAPNLARWDYHTTHINQLQLLSTIDESPVFKEFVKRWKSYLKGSRAKHN
The following text describes a protein:
Function:
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.
Subcellular Localization:
Nucleus.
Sequence:
MSLPLTEEQRKKIEENRQKALARRAEKLLAEQHQSSGSGSCIATNSSQSRQGLPPNLPGDPSKPVNHGVIFMQQNLSSSSSDGQRPHHCHSFHLSAPEQTERTWKRQEDVPAACPSHSSSGQMILTGISPPLAQSPPEVPDQQLLGCALGQGHLQASHEARSTPFANPTPESLAKAKSFQKTPASAFGLPPGDPRLEAKAVRPSTSGQTIAGVHCGSGSVTPRSEGRLSQKLGTAATHKAVSSQRGTCIRSGDRFQVKIGYNEELIAVFKSLPSRSYDPATKTWNFSMTDYGALMKAAQKLPTVTLQPLEGAGHSRESPSTGGTAQTCLPSAPSLAFVKGQCVLISRARFEADIGYSEALVALFKQMDSRSYDVKTRKWNFLLEEHNKLIQRVRCLPQVQLDPLPKTLTLAFASQLEKTSPCLTQPIPEADLSGVDPKLVSSLLPFQRAGVNFAIAKRGRLLLADDMGLGKTIQAICIAAFYQKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPERINVVVTGKDRLTAGLVNIVSFDLLSKLEKQLKTPFKVVIIDESHFLKNIKTARCRAAMPLLKVAKRVILLSGTPAMSRPAELYTQIIGVRPTFFPQFHAFGLRYCDAKRQPWGWDYSGSSNLGELKLLLEEAVMLRRLKCDVLAQLPPKQRKMVIIAPGRISTRARAALDAVAKEMTTMDKTKQQQKEALLLFFNRTAEAKIPSVIEYILDLLESGREKFLVFAHHKVVLSAVTRELEKKHVPHIHIDGSTSSADREDLCQQFQLFEKHAVAVLSITAANMGLTFTSADLVVFAELFWNPGVLLQAEDRVHRIGQSSSVSIHYLVAKGTADDYLWPLIQEKIKVLGEAGLSETNFSEMTEAPNYFYKDPKQQKIYDLFQQSFEEDGSDLELLEAAESSDPRSASGAPGNDFQDLGDTPDGTMVTGSPVKKRRFEFFDNFDSFTFPL
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end.
Sequence:
MDDEKEGRKKAVIDSAFFIQGADVEGLTTPGVVEEVKDPESRLFLEGLISAGKVKVVLPSRESIEAVREAAKKTGELGELSEADIEVLALAYEVDGVLLTDDYNLQNIARTLRIEFRTLKRGIKKVIRWNYVCIGCGKKFEEMPPGEVCPDCGSPVRLIPKRKRKRRPQRRRYGRTSS
The following text describes a protein:
Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release.
Subcellular Localization:
Nucleus.
Sequence:
MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEVLPLRPAREGELYFPEDREVNLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYQQVTRAVLGDDPQLMKIALQDLQTNSKIAALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLVRNPHLCLGPYVRSLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQQILLSLQKVLADPVRPLCSHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPTKGGPGGRGCRRSDDLPWDSLLLQESPSGGSAEPGFGSGLPLPPGGAGPEHPSPSVTLRDIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPDSVRKMPQLTASAVVSPQGDESPRGGGAPSASAPAASESRPLPRVHRARGAPRQQGPGAGTRDVFQKSRFAPRGAPHFRFIIAGRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPMIGRTGRPARRWALSDYSLYLPL
The following text describes a protein:
Function:
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control (By similarity).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MLAADDIGEVPAAPCCPESGDETKNTDVKSDVNTAAPAGSEQLSQGGSDDALLSYVSAFIEKEVGSDLKSLKTLGKLIEQMTESKVKLEEQVLTISSEIPKRIQSALKDAEESKQLLDEFLEQEAPLFSSISSHLLMAQPWMDDLGAMITQMEEIERHLAYLKWVSQTEELSDNIQQYLMTNSVPEAASLLVTMTELDIQLQESSCTHLLSFMRATVKFWHKILKDKLTSDFEEVLAQLHWPFTSHTQSQTVGGSRPAGTPELYSSLDTLFCQLLKLQASDELLTEPKQLPEKYCLPASPPVTLPIQVMLAPLQKRFRYHFRGSRQTNVMSKPEWYLAQVLMWIGNHTQFLDEKIQPILDKVGSAVNARLEFSRGLVMLILEKLASDIPCLLYDDSLFCHLVDEVLLFERELHTVHGYPSTFASCMHILSEETCFQRWLTVERKFALQKMDSMLSSEAAWVSQYKDISDVDEMKVPDCAEVFMTLLLVITDRYKNLPTASRKLQFLELQKDLVDDFRIRLTQVMKEETRAALGFRYCAILNAVNYISAVLADWADNVFFLQLQQAALEVFAENNVLSKLQLGQLASMESSVFDDMINLLERLKLDMLTRQVDHVFREVKDSAKLYKKERWLSLPSQSEQAVMSLSSSACPLLLTLRDRLLQLEQQLCFSLFRIFWQMLAEKLDLYIYQEIILANHFNEGGAAQLQFDMTRNLFPLFSHYCKRPENYFKHVKEACIILNLNIGSALLLKDVLQSVSEHIPATAALNEVGVYKLAQQDVEILLNLRTNWPNTGK
The following text describes a protein:
Function:
Converts GSH to 5-oxoproline and cysteine-glycine (Cys-Gly) dipeptide in vitro and plays a significant role in glutathione (GSH) homeostasis. Has no activity towards gamma-glutamyl-L-cysteine but possesses low activity towards gamma-glutamyl-L-alanine.
Subcellular Localization:
Cytoplasm.
Sequence:
MVMWVFGYGSLVWNPGFHYDEKVLGFIKGYKRVFDLACIDHRGTPEHPARTCTLEKAEEAICWGTAFCVRGGPEKERLAMEYLERRECEYDLKTSVDFYKEDDPLKPAVTGVIVFTSTPDKVSNKYYLGPAPLEDMARQIATANGPCGNNRDYLFLLEKAMHDIGHEEDYVIELANEVRKVLAESSTKKVTPVKESRASRVANKSKNNVPTAHQILPHHPEAVATTI
The following text describes a protein:
Function:
Efflux system for nickel and cobalt.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MISNFNLIMYKIAIYQQEIVEKISKLIEKENEKIIYTMLFFTFLYGIVHSFGPGHGKTLVLTYSVKEKLNFPKLLLVSFLIAYLQGVSAYILVKFIINLSDKASMMLFYDLDNRTRLIASILIILIGLYNIYSVLRNKCCEHHHETKVKNILGFSIVLGLCPCPGVMTVLLFLESFGLSENLFLFTLSMSTGIFLVILFFGILANTFKKTLVEDENFKLHKILSLVGASLMILFGIFQILILGE
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MTLTTLPQNARVAVLGAGISGLTFTYFLSKLRPDLQFTIFEKSKRPGGWMSSPKLHVNNTNESILFEKGPRTLRGVKDGTLLMLDILRKLDLDSQIEVINEKCNANKKYILDSSGEIIQVPNSIGTTIEFLKNVKCVDRKLITGIIKEPFVKPIKEDETIEQFFKRRLGSTVLTDNVASSIIHGIYAGDVGKLSIKSIMSFMKDIENQSGSIVKHIFKSLYSTKKKEEPQLSQELQTYNQLMSPKAELLTLQKTLKQYPMIKLHDGMETLPKYLAEYLINNTNTKIEYNTSIQDIDAVTGKINGESYDHIRSTINTHDLAKTLPTTDPLVPELKSIEYVSIFLTNVYSRSSNLIPKGKPGFGFLSPRYGNVWKNPDALLGTIYDSDIENNVEGLFVDTKPVHNPNNKITIMMGGHYYTNWTIPSNSVNLKIVKDVLTSKLKVDLSKFNLKVIKDGEPLQIDEINDNDLVISYNFHSNCIPQYNLGYQETKDKVNQLLDKGYKLSFGGTVFADGVGVPDCVLNGFKDALKLK
The following text describes a protein:
Function:
Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR.
Subcellular Localization:
Nucleus.
Sequence:
MEKSIRLKKEEDEYFSGPIGRFFLDIGLSLVQEYVQGDLLRVQKRKVHKGTKITDPSLSVNALTKGLDVTRAKNDPYRLPWRSCNQCSFKSESSLMMAHHKSLPLALGSGSSARYGCHWCSFEAKESHLVSLHIETDHGFSTRTGPDLPSHQCPLCPFEDNVKSKVTRHMMSCQKRFVADRNLEPPLDWEPPAKIPRMPTRYMRAYTPGMNAGTGLHGYSLTSTKGLNLPYHPLLPKSALMNSLGYNTLAGLRLPAELHVVSGASQRVSGTPSGSTPQPKGRDYRQQASNQSSSYLNPSSSTTPTTNKAKTNQQPSISITPLPRTSTSTLSNKPSLSVSPVTPAATNAMAAIGNNTLAAKAGQPATPGQKGAVVCEICDSSIKDLEQLRHHMQWIHKVKIHPKMIHNRPPLNCQKCQCRFFTDQGLERHLLGSHGLVTSSMQEAANRGQDGGRCPICGKVHQWKLLSHVVKDHGLSLKPAHLSYKCTVCTATFTMYKLFENHVYTAHSVVARKVLDKDKADTKKGSSGSTNTSTTGALRINDEITIIPQTTRHDSSDQNVCRPSRGEKRSRVDIIDLSDDEQDNKDGLTLPKSQVTITKVPAPKGYLSRNSRESMSKRSRTDDNDTE
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MEVAEDSSPVECSKKKSHEDGKRFSDEQVKVLESMFKQKTTLEPSKKLELARDLGLQPRQVAIWFQNRRARWKTKQLEHEYRRLKDEFDNLAIKFESLKKEKESLLKQLQELSDQMENNHAGCSRSQDSIDSEIYTSSENIEAEVDVKDNIPGCINTSLDHERIKGADSDIEGTLFEHLRWKEEEEFWNMEELGDSFLGSPEHWYAVGPGYSFDLSCENSKWWEF
The following text describes a protein:
Function:
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Contributes to n-hexane resistance.
Miscellaneous:
MISCELLANEOUS: The correct assembly of LptD depends on the thiol:disulfide interchange proteins DsbA and DsbC, the chaperone proteins SurA and Skp, LptE and the chaperone/protease BepA. Incorrectly folded LptD can be degraded by three different proteases, DegP, BepA and YcaL. These proteases act at distinct points in the outer membrane protein assembly.
Subcellular Localization:
Cell outer membrane.
Domain:
Contains an N-terminal soluble domain that is likely periplasmic and interacts with LptA, and a C-terminal transmembrane domain, which is predicted to be a beta-barrel and interacts with LptE. Residues 529-538 play a key role in interaction with LptE.
Sequence:
MKKRIPTLLATMIATALYSQQGLAADLASQCMLGVPSYDRPLVQGDTNDLPVTINADHAKGDYPDDAVFTGSVDIMQGNSRLQADEVQLHQKEAPGQPEPVRTVDALGNVHYDDNQVILKGPKGWANLNTKDTNVWEGDYQMVGRQGRGKADLMKQRGENRYTILDNGSFTSCLPGSDTWSVVGSEIIHDREEQVAEIWNARFKVGPVPIFYSPYLQLPVGDKRRSGFLIPNAKYTTTNYFEFYLPYYWNIAPNMDATITPHYMHRRGNIMWENEFRYLSQAGAGLMELDYLPSDKVYEDEHPNDDSSRRWLFYWNHSGVMDQVWRFNVDYTKVSDPSYFNDFDNKYGSSTDGYATQKFSVGYAVQNFNATVSTKQFQVFSEQNTSSYSAEPQLDVNYYQNDVGPFDTRIYGQAVHFVNTRDDMPEATRVHLEPTINLPLSNNWGSINTEAKLLATHYQQTNLDWYNSRNTTKLDESVNRVMPQFKVDGKMVFERDMEMLAPGYTQTLEPRAQYLYVPYRDQSDIYNYDSSLLQSDYSGLFRDRTYGGLDRIASANQVTTGVTSRIYDDAAVERFNISVGQIYYFTESRTGDDNITWENDDKTGSLVWAGDTYWRISERWGLRGGIQYDTRLDNVATSNSSIEYRRDEDRLVQLNYRYASPEYIQATLPKYYSTAEQYKNGISQVGAVASWPIADRWSIVGAYYYDTNANKQADSMLGVQYSSCCYAIRVGYERKLNGWDNDKQHAVYDNAIGFNIELRGLSSNYGLGTQEMLRSNILPYQNTL
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MSAMNEEIQRRQYEDLDSLLIVSREKWAFNIGYFCTDLLHSIMIRRITESQSMDHELWFAISKSKAQLSKYWNGQESVKLQTLLDMFRGGNFQQLGDVAKMTLVLIVNNILFGQDYCRRVTRWLLSLVEDIDAWNVFPWGHYAMKAIMALRKIVAPSGSKDNVYPRMCRWDYNQKSKNFFRLCALETLEPTADEAFWEYFVDLDVPLSEGHEYMPIRHMEDRSDWGLGARQKRKSLKEKRAFGGTKWMRTAAALVDELSGPELMDEGDDHGQGNEQSLDHAPVTPKPPTGLPQTQSGNDPSFRKGTTSPQASIVCRSDDRSLSIDSADLEHDDANDGHHHEPGVDIDDDILGADGEHVTNVNDVVDEAMAVDVTFQSDDVEGEHVPLPESIIDASIGGDGELDLIVAEGERLPPVDAFVDAAVGTIVLYRGSTPNAVEIRSSSPESSVVHHGAVEISDPIERAWLKMASKYMKTIEDYEAFKKDESTRRNIGILGDQGVNFFITLKDPNEEMTSEHIDVCLSLLCKTPSVCCTPNFQQKMPEPQCRFQMSYEGMWRVKGQHMPKNGKMWISSSLIATLDNGVRAGQMTPLMTMMPFICHQVDYFNNIRRKRRDLTSIPLDIHLPKVKVYRQNDSVSCGMFMIGSEQFNCYAWRVTTFNLLYMVCQNNSLVIHGGSNAYSMRILTFCLSKRRGSSCSEAFPSIPREAYIGLSTLCMKFGNSLGFRDQAISAEFATLHYMAVDFAKITAPAEMARSLKPREFPNFMQTVDKPMYASLGVLGKLYRATINSIMQARSKFDRPSLWIDI
The following text describes a protein:
Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLLLLGNTSLGSPNGSLALLPPSSPSSAALLQPPSPYSPAAVASLAALVGFIIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMNYWYFGKVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRIKAIIVTVWLISAVISFPPLISMYRDPEGDVFPQCKLNDETWYILSSCIVSFFAPCLIMVLVYIRIYRVAKLRTRTLSEKRTMPEGSSQTENGLSRAAGGCTSLRMQLGENGHYSVHHWRKASELEDIELEESSTSESRRRRSREEHPRKSSKSQSFSYSYSSKHSSSRLSRSSNRSMEFFSYRRRRKRSSICRKKVTQAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREACEVPETLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSFKHILFKKKKKNFRH
The following text describes a protein:
Function:
Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet.
Sequence:
MASAEKLYREKMQELQKQLNKFMQTINNHSKVDAFLNSPFGQYLDEHPFVTLSLLVFVSLSVVPAGLFLTLVAGTAIAVCLAVLIIEGIVISVSGIALLCILCGLAVMSLGVAAILCVSYVAGSSVFNYMHAYRVAVGTRERSGPISLNHKMTMAEKSLSSS
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MDAHNYHGSVSGKKSMEWASNDWKWDGDLFTAARRNNNSLPSDCCKSKQLMFPIGSEIHPEASRISNCFSSGSDELLTLGSNDKGRKELEKRRRAIVIEDDELDHEEEAGSLNLKLGGQLYPVMEGDEEKLEGKSGKKTKIVGVSSNRAVCCQVQDCRADLSNAKDYHRRHKVCDVHSKAAKALVGNVMQRFCQQCSRFHVLQEFDEGKRSCRRRLAGHNRRRRKTHPENVANGASMNDEGGINYLLISLLRILTNVQSNSSDQTKDQDLLSHLMRNLASLAGATNERNTSGLLSAPPEQWNAGTSMGASKEDSLKPTGNCLIPASEVTEKRMGRSDVEYGISQNPCAWQPDSLCCRKESSPINANASAKVKLNNIDLNNIYDDSQDGNQKLQNSDASANPGAASSGCPLWICHDPHKPSPGTSGNSGSTSSLSLSNSSGEAQSRTDRIVFKLFGKDPGDFPTALRKQILDWLSHSPTDIESYIKPGCIILTIYLRMDKSIWEELYCDLNSSLRKLLNASADSFWQTGWVYARVNDRVAFLFNGQVVLDTSLPVKSHRSCGISIVKPIAVCASERVQFLVKGVNLSRPTTRLLCALDGNYLVQGNCIDMMVGADSCMGHEDIQSLSFPCILPNVTGRGFIEVEDHGLSSNFFPFIVAEKDVCSEIRTLESNIEVAEMAGGFLQGTENLQARDQALEFLHEMGWLLHRSHLKFRVGSGVNLNLFPFQRFKWLIEFSIDQDWCAVVKKLLDVFFNGIVDVGQQSSLDIPLWEVGILHQAVRRKCRSMVEVLLKYRPHGAFDKSGPQKQQDDRDYLFRPDAVGPGGLTPLHLVASLSGFENILDALIDDPGQVGIEAWKSACDSTGLTPNDYACLRGHYSYIHIVQKKISQKRGDGHVLDIPGSLLDSSIKQKLSDDHRSVKVASLQTEKSLRKPIQTHCRQCDQKLYYGNSGSSLAIYKPAMLSMVAIAAICVCVALLFKSSPEVLYSFRPFRWELLKYGSI
The following text describes a protein:
Function:
Required for the intracellular transport of organelles and vesicles, and is essential for the photoreceptor's outer segments formation, maintenance and function.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm.
Sequence:
MDEDEQNRYVAQLKDEFDSCDTTGTGYLDKEELTALCHKLSLDAHLPLLLDTLLGPQHYARVNFEEFKEGFVAVLSRSLDFSTSEEESSYLEPAVPEEVKPKYVKGTKRYGRRSRPDKTDLELTADSDSLPFGTDKVEANGVRRAKLRRSTSLESVESLKSDEDTGSNKESTHHYFVAQGQLKLWNQDGTGNCQRSSDNQQEVTDGQVRAVWEELGVGAAGSLNREELSLVCDHIGLKHLEAEELDALFRKLDKDQDGKVSLIEFQSGLFKPHDHASPLSTSTPARPKPLRTISKALEERVVRSTSPSLLSATVGQRLLTRLDDGSGCTSPEKVMALWTEEGIHNSRDILQTQTLDFSLEERLCLAELTLALDNELLVSGNGIHQAALVSYKNEINYLQVLADQACQERDKAKADLEQADRRNLQLVREVDDRHATMESLNESKIKDLEQEFRDKLTALRSESEYESEVLLEQVEKERERLRDELQLLRSQDISLQEDMCTTVNENRRLEEEVSALKEKLTEAESAISKLQNDLDRLLQDKYDGLDANGTGLLNQEEQFTEIFKEYEQQCRELQDRNDELCSELELLKSQGSGKRTRLSRSSLPANDWSNRRALTTESDSDDPEMKKGTSPQVRKKLQVTDKNVLGSLESLAPPVSIETELAMEKMKERYEQEVQDLKIQLETKVNFYERSMDLMRQNMEVERKDISQSFKMEISELEDLKARAEERAEQMRQTTERLEAELRGKTSGGAWGQEQERRIQRERAELEQNYAREISNLVLRLTSEKDQLEAELKLRMDREVLLVRAQLDEVTSENCALKDRLAVLQQDVKSLEEDVNNKRKKLEEMEKGYMKNREDEERLRKENSKCREEVLDLSARNLQLSSENAELSSRLCTDQRAVQTLTDRLAQVCQERDAAAVSSKQLQENLQQQENHGLRLQEQWRKEKELLERELQTAKEALQHLTVVESALTSQTLKNKSLEQDKESLLKETAENDQKLKKLQEALRNSETQIEQLNAQILTMWQEKDVHVQEAAAHIKMLQQSQDKVQELEERISQLRKEKEQVQHTHRLQEETAVSVLQNECKSLRVQNKELQNKVAQLQSRELELQRLTHECLTLRNKQAELETAKQEANQQAMRAESTRSMVQAQHTREIQELKEQMGSGTQEHASHLQTQLAEQQRRTQDFEDLLRSQAKQASVQMGLQQEQYEKLMASMQERMDEVEAKLKNTRVMLQEKVNQLKEQLAKNSKSDVLLKDLYVENSQLMKALQVTEQRQKSAEKKSFLLEEKVIALNKLLRKIAPASLTA
The following text describes a protein:
Function:
Catalyzes the stereoinversion of LL-2,6-diaminopimelate (L,L-DAP) to meso-diaminopimelate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Subcellular Localization:
Cytoplasm.
Sequence:
MVFYKYSGSGNDFLIVQSFKKKDFSNLAKQVCHRHEGFGADGLVVVLPSKDYDYEWDFYNSDGSKAGMCGNASRCVGLFAYQHAIASKNHVFLAGKREISICIEEPNIIESNLGNYKILDVIPALRCEKFFSSGSVLEHIPTFYLIDTGVPHLVGFVENKEGLNSLNTLELRALRHEFNANINIAFIENKETIFLQTYERGVEDFTLACGTGMAAVFIAARIFYNTPKKAALIPKSNESLELSLKNDGIFYKGAVRYIGMSVLGMRVFENGCF
The following text describes a protein:
Function:
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Miscellaneous:
MISCELLANEOUS: Present with 573 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer.
Sequence:
MSDSPLSKRQKRKSAQEPELSLDQGDAEEDSQVENRVNLSENTPEPDLPALEASYSKSYTPRKLVLSSGENRYAFSQPTNSTTTSLHVPNLQPPKTSSRGRDHKSYSQSPPRSPGRSPTRRLELLQLSPVKNSRVELQKIYDRHQSSSKQQSRLFINELVLENFKSYAGKQVVGPFHTSFSAVVGPNGSGKSNVIDSMLFVFGFRANKMRQDRLSDLIHKSEAFPSLQSCSVAVHFQYVIDESSGTSRIDEEKPGLIITRKAFKNNSSKYYINEKESSYTEVTKLLKNEGIDLDHKRFLILQGEVENIAQMKPKAEKESDDGLLEYLEDIIGTANYKPLIEERMGQIENLNEVCLEKENRFEIVDREKNSLESGKETALEFLEKEKQLTLLRSKLFQFKLLQSNSKLASTLEKISSSNKDLEDEKMKFQESLKKVDEIKAQRKEIKDRISSCSSKEKTLVLERRELEGTRVSLEERTKNLVSKMEKAEKTLKSTKHSISEAENMLEELRGQQTEHETEIKDLTQLLEKERSILDDIKLSLKDKTKNISAEIIRHEKELEPWDLQLQEKESQIQLAESELSLLEETQAKLKKNVETLEEKILAKKTHKQELQDLILDLKKKLNSLKDERSQGEKNFTSAHLKLKEMQKVLNAHRQRAMEARSSLSKAQNKSKVLTALSRLQKSGRINGFHGRLGDLGVIDDSFDVAISTACPRLDDVVVDTVECAQHCIDYLRKNKLGYARFILLDRLRQFNLQPISTPENVPRLFDLVKPKNPKFSNAFYSVLRDTLVAQNLKQANNVAYGKKRFRVVTVDGKLIDISGTMSGGGNHVAKGLMKLGTNQSDKVDDYTPEEVDKIERELSERENNFRVASDTVHEMEEELKKLRDHEPDLESQISKAEMEADSLASELTLAEQQVKEAEMAYVKAVSDKAQLNVVMKNLERLRGEYNDLQSETKTKKEKIKGLQDEIMKIGGIKLQMQNSKVESVCQKLDILVAKLKKVKSASKKSGGDVVKFQKLLQNSERDVELSSDELKVIEEQLKHTKLALAENDTNMNETLNLKVELKEQSEQLKEQMEDMEESINEFKSIEIEMKNKLEKLNSLLTYIKSEITQQEKGLNELSIRDVTHTLGMLDDNKMDSVKEDVKNNQELDQEYRSCETQDESEIKDAETSCDNYHPMNIDETSDEVSRGIPRLSEDELRELDVELIESKINELSYYVEETNVDIGVLEEYARRLAEFKRRKLDLNNAVQKRDEVKEQLGILKKKRFDEFMAGFNIISMTLKEMYQMITMGGNAELELVDSLDPFSEGVTFSVMPPKKSWRNITNLSGGEKTLSSLALVFALHKYKPTPLYVMDEIDAALDFRNVSIVANYIKERTKNAQFIVISLRNNMFELAQQLVGVYKRDNRTKSTTIKNIDILNRT
The following text describes a protein:
Function:
Shows esterase and phospholipase A activities. May be involved in cell wall biosynthesis and/or maintenance. Can hydrolyze various substrates, including the p-nitrophenol-linked aliphatic esters pNP-laurate (C12), pNP-myristate (C14), pNP-palmitate (C16), pNP-stearate (C18), pNP-butyrate (C4), phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, 4-methylumbelliferyl heptanoate and palmitic acid and arachidonic acid containing phospholipids. Does not exhibit cutinase activity.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Secreted, cell wall.
Sequence:
MAKNSRRKRHRILAWIAAGAMASVVALVIVAVVIMLRGAESPPSAVPPGVLPPGPTPAHPHKPRPAFQDASCPDVQMISVPGTWESSPQQNPLNPVQFPKALLLKVTGPIAQQFAPARVQTYTVAYTAQFHNPLTTDNQMSYNDSRAEGTRAMVAAMTDMNNRCPLTSYVLIGFSQGAVIAGDVASDIGNGRGPVDEDLVLGVTLIADGRRQQGVGNQVPPSPRGEGAEITLHEVPVLSGLGLTMTGPRPGGFGALDGRTNEICAQGDLICAAPAQAFSPANLPTTLNTLAGGAGQPVHAMYATPEFWNSDGEPATEWTLNWAHQLIENAPHPKHR
The following text describes a protein:
Function:
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MAAEYWRELMKSSHAAGDVAGTRKDGGALKCLCLPRSVLFSSVRLPALFLFLCHSGNMGKTKNHLPDRWTDYTPLGKRIPGTRFIAFKVPLKKIFNSKIESWQRFSSADLIRDVQAQKEELGLIIDLTCTTRYYSPEELPESLHYAKIFTVGHEVPSDETIFQFKCIINRFLKENSNNDKLIGVHCTHGLNRTGYLVCRYLIDVLGMVPSDAIEKFNQSRGHCIERKNYLDDLMCGEMRRNAETDKPLLPLPKYHQKIPNVNNPSVPPCLTPPHRPEQPWFSRFGNPMDAPRIPEPRPIYSHPPRHNMPRPMYNDPAMDYNCHMYPREADWQQFQQWKPHPYHYGYQPPSRNPNGYQPPSRKPNGFQPSSRNTNNNQPPSRYPDTPQDSTPWQSASNDPYIRHSATGTNYQKN
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MAQAISASVAGALHAFPSFNTDNRYLKTSSVNISAWYSPPKWSLGVLAAGGSNKAHLSCASPSETGIVFKPCAELQNQIIKVPSSCSESLAQQQFSASCEAVIDDQINVEYNVSYVCHATLRIRENKRGGRVKLDTILSTVMEFDHSEKGDTLYSMELTLALERLVNEKLLSLHQVAVDNNDPEMCDFIEREYLYEQVEAIKKISMYISQLRRVGKGHGVELWRNNNSLCRCHHAVQASDILWCK
The following text describes a protein:
Function:
Arginine hydroxylase that mediates hydroxylation of 'Arg-111' of NDUFS7 and is involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. May also have methyltransferase activity.
Subcellular Localization:
Mitochondrion inner membrane. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane.
Sequence:
MNVSVKSLRGVSRTWRSFSSRQGMNVFDRSMKRRQKDWASSLLDSSKYDYLREEVGSRVADRVYDVARTFPLALDVGCGRSHIAEHLSKEVVERLFLTDISSSSLRNRKTSDIPAQCVMADEEFLPFKENTFDLVLSSLSMHWINDLPGALRQIHQVLKPDGVFIGAMVGGETLYELRCSLQLAELEREGGFAPHISPYTAVTDLGNLLGQAGFNMLTVDIDEVQVNYPGMLEVMRDLQGMGESNCAWNRKLLLQRDTMLAAAAIYKEMYGNEDGSVPATFQILYMIGWKPHDSQAKPAKRGSANVSFADLSKIGKLQSDQ
The following text describes a protein:
Function:
Protein N-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDLEDDETPQLSAHALAALQEFYAEQKQQIEPGEDDKYNIGIIEENWQLSQFWYSQETALQLAQEAIAAVGEGGRIACVSAPSVYQKLRELCRENFSIYIFEYDKRFAMYGEEFIFYDYNNPLDLPERIAAHSFDIVIADPPYLSEECLRKTSETVKYLTRGKILLCTGAIMEEQAAELLGVKMCTFVPRHTRNLANEFRCYVNYDSGLDCGI
The following text describes a protein:
Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Subcellular Localization:
Secreted.
Domain:
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Sequence:
MVLVTLLGLSWFCSPLAALVLDFNNIKSSADVQGAGKGSLCASDRDCSEGKFCLAFHDERSFCATCRRVRRRCQRSAVCCPGTVCVNDVCTAVEDTRPVMDRNTDGQDGAYAEGTTKWPAEENRPQGKPSTKKSQSSKGQEGESCLRTSDCGPGLCCARHFWTKICKPVLREGQVCSRRGHKDTAQAPEIFQRCDCGPGLTCRSQVTSNRQHSRLRVCQRI
The following text describes a protein:
Function:
Involved in the regulation of the larval diapause.
Subcellular Localization:
Secreted.
Sequence:
MFSTRGVLLLLSLMAAVAAFGLFSRPAPITRDTIRPPRAKHGSLKLCPPGGASFLDAFNLICPMRRRRRSVSENYNDGGGSLLGRTMNMCCETGCEFTDIFAICNPFG