lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MASFVTVRGKAISLESQCDSLLSRYSSYAQSTSSEADSKERGLAEKLESVLKERQGVIEELQRICDDTTSIGSSKLSQLQRHREVLQQHWQTFQSIRSSIQQERSRLNLLFSVKRTLEQSELEEQPQEEQYAAAETRRIEESHNVLDRLISQAFETRDRFAEQRFSLQRANDRVYQTLQRIPGINHVLSQITIRRRKNAMILALTMTICIVLLYWNMVG
The following text describes a protein:
Function:
Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR.
Subcellular Localization:
Nucleus.
Sequence:
MDMAEEAEMGEIEEMHSKEDEEVTASDQLLNGDLSEVENGEEEEEEEEEEEDSQSSIKKGQTTDDTDSMDVDEEQQEQQQIDSPPDNNTNKSEKDDNTEPDDGETEKDDDDGDSVKSDSDSKTSDMMENGKSADEEVHEIIDDDEPIELNDSGDGDGDGDVMIIEEPKENGSMEEEKNELEVIELDTTPIKKHKDLTILTPRRSVRNLNKSKSYVESEKAQNSHSSEESDIEEVLPQDPLAMGNDKIEVKRSKHSNSSTIVVKDTKRLVEIAAKSNSNNSGNKKEPTLVIIDTNSILSGRGPVPVNNKSSSSSNQYPTLLPMALPAQGMYPPNMRATITPIPLNSSTASTTTPPPPPLTKAPSTCINPAALAPVLPTLTDDMFVVEAPSFIVPYVYEKPPVSDFKDFLKELRDKLTEDDDKETTKSDDEAAAPTTTKDDDLLDPLKKNYSYFDSPLGKFFIDIGFNLVQEFVQADMLRQQKKKRDREGGQNPATNKTIHSLMKNLEFTKESNEPFRTTMKKCEFCNFKTESQLVMAYHLETPHTKNYVYKCNFCTYEARSPHDILFHMEAEHAVRGRLERAPSFHQCPNCPFEDNQKGKLSRHLVACMRKFKPERNLDPPIDWEPPAKIPRVPKARQGINVSAYQAMKSSQLQFLSKMQLLNTNSSSTSQALHRGRGRPSLGSTSIKQSMIRPSGMVYKQTMSGGSVLVPTNYQVSGNQVYQNQSKNKSVHQPSISITPLPRASASPNSNLTSKPGDTNSKNSFVICEICDGYIKDLEQLRNHMQWIHKVKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQDAANKSKDAGRCPVCGRVYQWKLLNHVARDHSMTLKPAHLSYKCTVCTATFGMYKQFENHVYSAHSVVAKRVMDKKNSSSSKNDQMMKPLKINDEITIIPQPAKVAAKEGSPSSSTGSTNSRNSTPSTSKNADSTNASSDAKGAE
The following text describes a protein:
Function:
Transcription factor involved in the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Plays a role in plant immunity and abiotic stress responses.
Miscellaneous:
MISCELLANEOUS: Expression and cleavage of bZIP60 in anthers observed in the absence of stress treatment, suggesting that the ER stress response functions in the normal development of active secretory cells; MISCELLANEOUS: [Isoform 2]: Potent transcriptional activator. Induced by IRE1-1 in response to endoplasmic reticulum stress. IRE1-1 cleaves a 23-bp fragment causing a frameshift of the mRNA transcript.
Subcellular Localization:
[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein; [Isoform 2]: Nucleus. Note=The bZIP domain is translocated into the nucleus in response to ER stress.
Domain:
The C-terminal transmembrane domain is cleaved in response to ER stress and the N-terminal fragment containing the bZIP domain is sufficient for transcription activation.
Sequence:
MAEEFGSIDLLGDEDFFFDFDPSIVIDSLPAEDFLQSSPDSWIGEIENQLMNDENHQEESFVELDQQSVSDFIADLLVDYPTSDSGSVDLAADKVLTVDSPAAADDSGKENSDLVVEKKSNDSGSEIHDDDDEEGDDDAVAKKRRRRVRNRDAAVRSRERKKEYVQDLEKKSKYLERECLRLGRMLECFVAENQSLRYCLQKGNGNNTTMMSKQESAVLLLESLLLGSLLWLLGVNFICLFPYMSHTKCCLLRPEPEKLVLNGLGSSSKPSYTGVSRRCKGSRPRMKYQILTLAA
The following text describes a protein:
Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MHRALLHVSRRAGAVRNLASTVEGDAFRLNEYSSKYLGHRKAAFTEKLEIINADDTPAIPIYRVTNAVGDVIDKSQDPNFDEPTAIKMYKTMTQLNIMDRILYDSQRQGRISFYMTSFGEEGNHVGSAAALESHDLIYGQYREAGVLLWRGYSMENFMNQCYGNADDLGKGRQMPMHFGAKERNFVTISSPLTTQLPQAVGSAYAFKQQKDNQRIVVVYFGDGAASEGDAHAAFNFAATLKCPIIFFCRNNGYAISTPTSEQYGGDGIAGKGPAYGLHTIRVDGNDLLAVYNATKEARRVALTNRPVLIEAMTYRLGHHSTSDDSTAYRSAEEVETWGDKDHPITRFNKYITERGWWNEEKEKDWQKEVKKRVLTEFSAAEKRKKAHYHDLFDDVYDELPLRLRRQRDELDAHIKEYKEHYPMDGLKETHNH
The following text describes a protein:
Function:
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end; Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MITVEPEKQAAFSADKTVFRKRNRLEAQQKQINSQKVSSNKLQTSVTDFRSALNQLNQRDSGLLKIKTTSSDDKLVSASATAQAVKGKYHLFVEQLAKTDQIALKGITDNQLTLAAGPIDLSVGKTTLTVDLTSVNSLEELANAINNASDKAKNSDGQGITASLVRTGSDVVLTLSSNKSGAAHKLDVSKLTTKISAATEQQLAAGQDAIVWLGEQNKGIKITHDTNVLDKAIQGLTLSLQKEKVAVEVGVEIDNEASEEQLKTFVSKFNQLQKLVESSSSVPNASAISTLLNNIIRSPIDGERIYAFGVTSGRDGELTIDSKQLQQTLSSNTQHFNEFFNGKNGVVNKLTEALEPYINVTSGLFKLDNDRLSLDITAIEKELKVVKDDYDNAYDKYLVVYTGIRNMLTKMNATLELFKPEKEQK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATKEGMQSGFGLRFHAELEQMVHRRIKTEEDDPWDPPPGTGLQEAPHITHVGSIQGFLQKPLVAQESENRLHQYWENQWQDFLTTLECPHSEWEPRVLWEDPAPWNNAKAFLASFEQVAEACHWPREDWMVCLLPALHGEAEQIFRNLDARDRIDYDKVKGAILRGDAIARERQRQNFRRFCYQEDQGPRGVWSQLQKFCHQWLKVERCTKEQVLELIILEQFMAILPLEMQNWVWEHGPETCSQAVALAEDFLLSHQREDHWEEEDLGPIEEVALNFSEDEEPPSNGGQKQGPRQDKQLCGGDAGSSGEEGWVSSNEEEPFQSETLDPVHQNRSSSLRSPDHQTFHSHEQDDASEGNSEEKKPHRCSECGKAFIAKAHLIIHQRIHTGEKPFQCLACGKMFAQRSNLTVHQRIHTGVKPFQCSDCGKSFCSSTNLTKHQSIHVKGNPYKCLACGKSFKIHTHFLAHKRMHAKKKTHKCSSCGKCFLAASHLIIHERIHTGEKPYECLECGKLFSQNAHLTVHQQIHKRIKSFKCSSCGEIFASRVTLIQHQTTHRRGNPYKCSDCGKTFRVNSHLIAHKRSHAAKKPNKCSYCGKCFFTKSYFIIHQRIHTGERPYKCLTCGKCFRQSSHLNAHKRTHTGVKPFPCSVCGRGFSSTKNLIKHQRTHKGEGLYMCPDCGKSFKVHSHLIAHEKIHAVKKPHKCSYCGKAFIANSYLIIHQRIHTGERPYKCRLCGKSFTQSSHLTVHERTHMGKKPFQCSECGKSFRAKSRLIAHERIHEVKKPHKCSYCSKSFVFKSYLIIHERMHTGERPYKCPVCGKSFSQSSHLNVHRKIHMEKKPFQCSECGKSFRTSSQLLAHKKIHAVSQPHNNKCLDCGKTFISKSYLIIHQRIHTGERPYKCAACGKCFSQSSHLSVHQKTHEGMALFQCSQCGENFGSQMKLLKHQRNHMKGSIFPCLECGKSFVTKSQLVIHQRSHTGERPYKCLNCGKGFSQSSNLIRHQRIHSGENPFRCLNCGKSFCSAENLSKHQRIHT
The following text describes a protein:
Function:
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDAVTVNNFFLIGAVLVGMSILVSSLSSRLGIPILVIFLAVGMIAGNDGVGGIVFDNYPMAYLVGNLALAVILLDGGLRTRVSSFRVALWPALSLATLGVLVTTGLTGIAAAWLFDLHWMEGLLIGAIVGSTDAAAVFSLLGGKGLNERVTATLEIESGSNDPMAVFLTVTLIEMLASGQTGLSWGFALHLVQQFGLGALLGLGGGWLLLQLINRMHLAGGLYPLLVISGGLLVFALANAVGGSGILAIYLCGLLLGNRPIRSRHGILHMLDGMAWLAQIGMFLVLGLLVTPHDLWPIALPALALALWMILVARPLSVLIGLIPFRAFHDREKAFIAWVGLRGAVPIILAVFPLMAGLPNAQLFFNVAFFIVLVSLLVQGTSLPWAARLLRVVVPPDPAPISRAGLEIHPTSEWELFVYHLNKEKWCIGAALRELKMPGGTRIAALFRGTELLHPSGSTILEADDILCVIGHEHDLPALGKLFSQAPDRGLGARFFGDFVLEGDAQLSAVASLYGLKLDGIDGEQALGRFIAHEIGGEAVIGDQVEWNGLTWTVAALEGNRIRKVGVKFPEGRPGPGLFL
The following text describes a protein:
Function:
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
Subcellular Localization:
Nucleus.
Sequence:
MAKDMKNRLAFLRRRNESPGSTPASKLDKTMKSVKPTPEEAMKWGESLDKLLVHKYGLAAFRAFLRTEFSEENLDFWLACEDYKKIKSQSKMTSKAKKIFAEFIAIQSCKEVNLDSYTREHTKENLQNINRSCFELAQRRIYGLMEKDSYPRFLRSELYMDLVNQKKPSTTSTSSSS
The following text describes a protein:
Function:
Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus.
Sequence:
MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSDSLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL
The following text describes a protein:
Function:
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MASNNLLVDLKRCFSAPSLRSYLAEFISTFLFVFTAVGSAISARMLTTPDVTSSAGPLVATAVAQAFGLFAAVLIAADVSGGHVNPAVTFAYAIGGRIGVPSAMFYWASQLLGATFACLSLNLFSAGEEVPTTRIAVAMTGFGGAVLEGVLTFLLVYTVHVVGEREPRSRGGDGKREFAATALGALAVGLTQGAFVLAAGALTGASMNPARSFGPAVVSGHFKNQAVYWAGPMVGAAVAALVYQIMACPSVTGNVEAVVV
The following text describes a protein:
Function:
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes at sites of cell fusion during mating.
Sequence:
MSGFKCYLQLGDRLSQIWLNKYTLVLLLAMLKLLFFSKSIQHAIEVSETYILSNCYSIDSLYSKMTDNTPHYLGIMGNYLIEKGMEETVKATLETLSLIVYASEGLVNFAIDLYLGTYACLIVSAVDGTVDVATNITEKLISLVNDTVSSVANELDTGLNDISKIINKVIKAASKVENFFTGDDDDSNMTSSIKSVNLTISALHNLYIPSSINDKLEELSAKTPDFAQVKNTTKNLISVPFNEVRKNIKAVNASNIIGDTSVLYVPPVSLDNSTGICSSNQSEILAFYSILGHVLKIATVVCITVLICFAVGAMAPVAWNEIKLWRRLCGMRDHYMLSRQDSYTSFSSENTHELKDPFRDPPIQNGQYDVIASYQQCFQTWNTRIAGWMTNLVTFGKSPENIDPKTKQKIEWVVAYMTSERALCVLGIGLLGILVCICQFVMIALLKHKISHSLTSNDGDGVQNLLKSSTAVDIENQMSLWSVQTNKYINTTETNINQEVFGWINTTTLSVNNTVATMISDIDTTLADVFNGTLLYNPMKTVVGCAIENKLYTIEKAMTWIHDKAQLHIPRINGTQIKQALAKQTDNSTIPTASSTSAATENLLENLVNDMREGLLKILRAYHRITLGELTVALVILAVWLVQLPIALVILRLRLRKATFD
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEYADCTEVAKKALEFRQQFYQLLDNPERRGDIVALYAPNTPLLCEWNGHALPDTASIAAYLGGLPRTNHKVDCVDAQPLPGNERADSFLMTVHGVVTYDDEHKREFFQRFVIRKVEERYYIMNDYYRWLSEKE
The following text describes a protein:
Function:
Catalyzes the insertion of Co(2+) into sirohydrochlorin. To a lesser extent, is also able to insert Fe(2+) into sirohydrochlorin, yielding siroheme. Its periplasmic location means that it cannot participate in cobalamin biosynthesis and its genomic environment suggests it is likely to be associated with a heme or metal transport system.
Miscellaneous:
MISCELLANEOUS: Binds 1 heme b (iron-protoporphyrin IX) group per dimer, which is not required for chelatase activity but may be linked to the putative transport function; MISCELLANEOUS: Desulfovibrio vulgaris possesses two versions of CbiK encoded within the genome, one cytoplasmic (CbiKC) and one periplasmic (CbiKP).
Subcellular Localization:
Periplasm.
Sequence:
MSRHPMVTRLLCLVFSCLIILACSPAFAGHGAPKAQKTGILLVAFGTSVEEARPALDKMGDRVRAAHPDIPVRWAYTAKMIRAKLRAEGIAAPSPAEALAGMAEEGFTHVAVQSLHTIPGEEFHGLLETAHAFQGLPKGLTRVSVGLPLIGTTADAEAVAEALVASLPADRKPGEPVVFMGHGTPHPADICYPGLQYYLWRLDPDLLVGTVEGSPSFDNVMAELDVRKAKRVWLMPLMAVAGDHARNDMAGDEDDSWTSQLARRGIEAKPVLHGTAESDAVAAIWLRHLDDALARLN
The following text describes a protein:
Function:
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Subcellular Localization:
Secreted.
Sequence:
MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (By similarity). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA longer than 15 bp, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish).
Sequence:
MENFAEKKISKPLTFGEGIQYVLDRISIKPEDRQTFKEDAQQIQNEFVRAISKQDPYFASAFRGLALTGSSLDNVRINLPDEFDMLTKIKMPCKLEPVPIRSHPGYVFLRASGDNIPIHLVDRWEDEYCIDRLKVQAWFRDNITAVIPELSNIRCNDGRSYELVNKTIGDVAHTIQAKCLSDPDRSISFDFVPAFEFSASEWPRIFPQHRNEDRSWYAVPSEFKYPNVGDDPLSFLVCAPYWERMVLTKKQHLKDGYRLMKAMRDANDMPKIYSYTIKSVFLNASNVNKLINWNQSPGRILIRAIDLLAMFLRKGKLPSYLVPDRNMLDRLSVDMRQDYRRKLCHIFRRLIRCRDRDCMTSEDLQFIFGMRY
The following text describes a protein:
Function:
A beta subtype methylase, recognizes the double-stranded sequence 5'-ATGCAT-3' and methylates A-5.
Sequence:
MRTGCEPTRFGNEAKTIIHGDALAELKKIPAESVDLIFADPPYNIGKNFDGLIEAWKEDLFIDWLFEVIAECHRVLKKQGSMYIMNSTENMPFIDLQCRKLFTIKSRIVWSYDSSGVQAKKHYGSMYEPILMMVKDAKNYTFNGDAILVEAKTGSQRALIDYRKNPPQPYNHQKVPGNVWDFPRVRYLMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAIASGRKFIGIEINSEYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKRSRLSEVDPDLITK
The following text describes a protein:
Function:
Part of the ABC transporter complex NrtABCD involved in nitrate uptake. The complex is probably also involved in nitrite transport (By similarity). NrtA is the substrate-binding protein. Binds nitrate.
Subcellular Localization:
Cell inner membrane; Lipid-anchor; Periplasmic side.
Domain:
Composed of two domains (I and II) organized with a C-clamp shape.
Sequence:
MSNFSRSTRRKFMFTAGAAAIGGVVLHGCTSPTTTSTGTGTGSSTDQAISPLVEGENAPEVTTAKLGFIALTDAAPLIIAKEKGFYAKYGMPDVEVLKQASWGTTRDNLVLGSASGGIDGAHILTPMPYLITMGTVTDGKPTPMYILARLNVNGQGIQLGNNYKDLKVGTDAAPLKEAFAKVTDPKVAMTFPGGTHDMWIRYWLAAGGMEPGKDFSTIVVPPAQMVANVKVNAMESFCVGEPWPLQTVNQGVGYQALTTGQLWKDHPEKAFGMRADWVDQNPKAAKALLMAVMEAQQWCDQAENKEEMCQILSKREWFKVPFEDIIDRSKGIYNFGNGQETFEDQEIMQKYWVDNASYPYKSHDQWFLTENIRWGYLPASTDTKAIVDKVNREDLWREAAQALEVPADQIPSSPSRGIETFFDGITFDPENPQAYLDSLKIKSIKA
The following text describes a protein:
Function:
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
Sequence:
MIRTVDIYDTSIIGVFATCTEDVVLVPPLTKPEVCALLEEVLDVRVIETLVNGSIVVGALSRGNSNGFMLPYGARAEMQRFTDIPVGILPDRLNAVGNIVFANDSAALVHPDLSDKALEAIARTLKVDVYRGTIAGIKNVGMAGVVTNKGLLVHPKVTASEREVLEKIFGFPVNIGTTNFGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALGFLE
The following text describes a protein:
Function:
Probable chloride channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAAIATVPNYTPSVWVRLCHAIPRLSLTMQMRDSVFTPDSWEYQQTLLVLSSFSAIALVLSLLVILCFLIHYCCCHRGESGRDAEEEEEDDDASGGHGYSGKKGRGICCVTWVSVAAVTLCCVAIGVGFYGNSEANDGMYQLTSSLLTANYTLASIDLLVSDTISGLQRSVSGPLTSMEDVFGGHKPALVPTRSCRRLSERVVSLLSNLTLGRGLIPIADGFYRTNGSESIVGALTPAPPSVAPTLSPSANSIPAPFSPGWAANTLMVNEDYRWLSYVLLLLVDLVVCFFILLGLAKQSRWLLILMTVLAWLSLFMSWGSLGLETPTVVALSDFCFDPNTFVLNSTHFNSGTSPEVLDYYLTCSRKMSSPFQQILTQSQRALSSIHSHLSSLERDALPRFPKAERSLREVQQILNTTEGNFHQLVALLNCRGLNKDYVDSLKGLCYDGMEGLLYLSLYSFLSALAFTAILCSLPGAWRSFHSDSDDYEDSDSESEDPFTSHQARRQTATGSQRGALPPFYSYQGAAWTPPFSSAPPLPTPNVSSNGNPGYENLPLSDRQSPPPSYSPSMLTGYGGSQSHSNPSHSRNLYSH
The following text describes a protein:
Function:
Involved in the final steps of cholesterol and steroid degradation. Probably catalyzes the oxidation of the 5-OH group of (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA, leading to the formation of HIEC-CoA (Probable).
Sequence:
MNLSVAPKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVISDHHERRLGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMGRLDVLVNNAGLGGQTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAPHGGVIVNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSIARHKFLDKTASAELLDRLAAGEAFGRAAEPWEVAATIAFLASDYSSYLTGEVISVSCQHP
The following text describes a protein:
Function:
Has intrinsic autoadenylation and autophosphorylation activities, probably on Ser or Thr residues.
Sequence:
MYKTIIMPVDVFEMELSDKAVRHAEFLAQDDGVIHLLHVLPGSASLSLHRFAADVRRFEEHLQHEAQERLQTMVSHFTIDPSRIKQHVRFGSVRDEVNELAEELGADVVVIGSRNPSISTHLLGSNASSVIRHANLPVLVVR
The following text describes a protein:
Function:
This protein is an alkaline zinc metalloprotease from snake venom that possesses weak hemorrhagic activity.
Subcellular Localization:
Secreted.
Sequence:
MIQVLLVTICLAALPYQGSSIMLESGKVNDYEVVYPQRLAPLPEGAVQQKYEDTMQYEFKVNGETIVLHLEKNKGLFSKDYSETHYSPDGRKITTYPSVEDHCYYHGRIENYEDSTASISACNGLKGHFKIQGETYFIESLKLSDSEAHAVLKYENVGKEDETHQICGVTLNWKSYDPIKRPSRLNLTPKQQTWPQTSVNLQLIVDHSMYAKYNSNSEKITKTVQERVNIMKEIFKPLNFDITLSGIEMWDKKDLITVKTAATDTLKLFAKWRQTDLLKRIDNDNAQLQTAVDFDGETVGLAFKSTMCDKRYSAGIIQDHSAIPLLMAVTIAHELGHNLGMDHDDTSKCNCNVCIMAPRLNTNPSKTFSDCSNNDYQKFLTDKKPKCIHKKSLKTDTVSTSVSGNEPLDDNVDGFHA
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MANLRDIRKKIGSVKNTQKITHAMKLVSTSKLRKAEEVARNSRAYALKLDAVFDDVLSKMKNQGIEDIQSKYFRELERLEIKKVDIIFITADKGLCGGFNTNTIKKVLACTNEYKEKDIKVRLRGIGKKGNEYFSFNGIEVLDKINNLSSMPNYERVQEFMKKVVEDYLSGKTDKVIIIHNGFKNMITQEIRVKTILPIGYKIIHQNPQPSETQETITSEPSGSEDEILDSLAEKYVEYSLYYALIDSLAAEHSARMQAMDTATNNAKDLVKTLTISYNKARQEAITTELVEINAGVEALK
The following text describes a protein:
Function:
Plays a fundamental role in building the proper chromosome structure at the beginning of meiosis in male meiocytes. Required for the transition from leptotene to zygotene in meiocytes. Required for homologous chromosome pairing, and initiation and progression of meiotic recombination. Regulates meiocyte cytoskeleton organization.
Subcellular Localization:
Nucleus. Chromosome. Note=Diffuse localization in the nucleus during the initiation of meiosis. Binds to chromatin in early meiotic prophase I.
Sequence:
MDVETVQAGPALAAHLQLQASPKPQVKKYYFKKKTSSSHSRNGKDDVNHDSTIQPRSPLSRQSLTFDAIPTYHAGAFYEIDHDKLPPKSPIHLKSIRVVKVSECTNLDITVKFPSLQALRSFFSSYPAPGTGPELDERFVMSSNHAARILRRRVTEEELEGEVQQDSFWLIKPRLYDFAAPQQVPSRTLCLPPPPAPPAATLGLTADSCLLTTLKCDGAGWGMRRRVRYIGRHRDEAPKEASVDGYDTESSVREVQQPPATQEVKRSERNCKRKREAEASSKDNNGDEGKKNNKVQGASKKISKKAKKRTVESKDGDPRHGKDRWSAERYAAAEKSLLNIMRSRDARFGAPVMRQVLREEARKHIGDTGLLDHLLKHMAGRVPEGSVHRFRRRHNADGAMEYWLEPAELAEVRKQAGVSDPYWVPPPGWKPGDDVSLVAGDILVKRQVEELTEEVNGVKRQMEQLLCKDDGDFGAERDYSSLKEKYQRAVRANEKLEKQVLCLKDMCENVVQMNGELKKEVSAFKEKYEHIADKNDKLEEQVTYLSSSFLSFKDQLVVALKLELAPSEAVPRTALFVASGEQMTGTVIQGGQDRAERKSSFRVCKPQGKFLLPSMASGMTIGRGASSTCPAAATPGPGIPRSTSFPSMPGLPRSSRGPVEVVAAASGLDEHVMFGAHFSTPPSASSTNDAAKLQLSLPSPRSPLQPQKLFDTVTAAASGFSPQKLMHFSGLTRRDVDTSSSSSGACGSGLLEGKRVLFDADAGGISAVGTELALATPSYC
The following text describes a protein:
Function:
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Sequence:
MVAAFSYTACTKLSLLHPSMVAQIRPRTTQKAFVVTNPEQDSTLEVQETETLKEEQSTEKMKKQPTPLRPVEKQLNVKSKGMGDFGGQWLSSVTRHVRIYAAYIDPETCEFDQSQMDKLTLILDPTEEFVWDDESCNKVYSYFQELVDHYEGAPLTEYTLRLIGSDVEHYIRKMLFDGEIQYNMDARVLNFSMGKPRVQFNTSNIEGGGDGQPQEDA
The following text describes a protein:
Function:
Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MNGGKECDGGDKEGGLPAIQVPVGWQRRVDQNGVLYVSPSGSLLSCLEQVKTYLLTDGTCKCGLECPLILPKVFNFDPGAAVKQRTAEDVKADEDVTKLCIHKRKIIAVATLHKSMEAPHPSLVLTSPGGGTNATPVVPSRAATPRSVRNKSHEGITNSVMPECKNPFKLMTGSSNAMGRLYVQELPGSQQQELHPVYPRQRLGSSEHGQKSPFRGSHGGLPSPASSGSQIYGDGSISPRTDPLGSPDVFTRSNPGFHGAPNSSPIHLNRTPLSPPSVMLHGSPVQSSCAMAGRTNIPLSPTLTTKSPVMKKPMCNFSTNMEIPRAMFHHKPPQGPPPPPPPSCALQKKPLTSEKDPLGILDPIPSKPVNQNPVIINPTSFHSNVHSQVPMMNVSMPPAVVPLPSNLPLPTVKPGHMNHGSHVQRVQHSASTSLSPSPVTSPVHMMGTGIGRIEASPQRSRSSSTSSDHGNFMMPPVGPQATCSGIKVPPRSPRSTIGSPRPSMPSSPSTKSDGHHQYKDIPNPLIAGISNVLNTPSSAAFPTASAGSSSVKSQPGLLGMPLNQILNQHNAASFPASSLLSAAAKAQLANQNKLAGNNSSSSSNSGAVAGSGNTEGHSTLNTMFPPTANMLLPTGEGQSGRAALRDKLMSQQKDSLRKRKQPPTTVLSLLRQSQMDSSAVPKPGPDLLRKQGQGSFPISSMSQLLQSMSCQSSHLSSNSTPGCGASNTALPCSANQLHFTDPSMNSSVLQNIPLRGEAVHCHNANTNFVHSNSPVPNHHLAGLINQIQASGNCGMLSQSGMALGNSLHPNPPQSRISTSSTPVIPNSIVSSYNQTSSEAGSSGPSSSIAIAGTNHPAITKTTSVLQDGVIVTTAAGNPLQSQLPIGSDFPFVGQEHALHFPSNSTSNNHLPHPLNPSLLSSLPISLPVNQQHLLNQNLLNILQPSAGEGKSEINLHPLGFLNPNVNAALAFLSSDMDGQVLQPVHFQLLAALLQNQAQAAAMLPLPSFNLTISDLLQQQNTPLPSLTQMTAPPDHLPSNQSDNSRAETLLTSPLGNPLPSFAGSDTTFNPLFLPAVNGASGLMTLNPQLLGGVLNSASANTANHPEVSIATSSQATTTTTTTSSAVAALTVSTLGGTAVVSMAETLLNISNNAGNTPGPAKLNSNSVVPQLLNPLLGTGLLGDMSSINNTLNNHQLTHLQSLLNNNQMFPPNQQQQQLLQGYQNLQAFQGQSTIPCPANNNPMACLFQNFQVRMQEDAALLNKRISTQPGLTALPENPNTTLPPFQDTPCELQPRIDPSLGQQVKDGLVVGGPGDASVDAIYKAVVDAASKGMQVVITTAVNSTTQMSPIPALSAMSAFTASIGDPLNLSSAVSAVIHGRNMGGVDHDGRLRNSRGARLPKNLDHGKNVNEGDGFEYFKSASCHTSKKQWDGEQSPRGERNRWKYEEFLDHPGHIHSSPCHERSNNVSTLPFLPGEQHPILLPPRNCPGDKILEENFRYNNYKRTMMSFKERLENTVERCAHINGNRPRQSRGFGELLSTAKQDLVLEEQSPSSSNSLENSLVKDFIHYNGDFNAKSVNGCVPSPSDAKSISSEDDLRNPDSPSSNELIHYRPRTFNVGDLVWGQIKGLTSWPGKLVREDDVHNSCQQSPEEGKVEPEKLKTLTEGLEAYSRVRKRNRKSGKLNNHLEAAIHEAMSELDKMSGTVHQIPQGDRQMRPPKPKRRKISR