The following text describes a protein:
Function:
Catalyzes the synthesis of the second messenger cGMP from GTP (Probable). In asexual blood stage schizonts, required for cGMP production which is essential for PKG activation, PKG-dependent Ca(2+) release, and ultimately merozoite egress from host erythrocytes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=In gametocytes, localizes to the cell membrane and/or the parasitophorous vacuole membrane.
Domain:
The N-terminus contains a P-type ATPase-like domain which may be important for guanylate cyclase activity.
Sequence:
MSDSKKHYNESNVRYKVKYSGKIFGNNMKKLNENNNHDFTTAEAAWMEKKKKLYKDTNNQPLWDFRKIQINPTETDELISFPSNKICSKNYGKYSFIFKGLYEQFLRLPNIWFLLISLLEFIPQYQNLSNYMYYSKHSSFFLLLFFICVSIIKNIYEDSRRSNIDYQINNRLCHMLDGPNSQLKAVRWMELSVGSIIRLIENEQVPADILLLSCNNSEGVVYIETSLLNGETNLNKKYCVNETRNETSIYAISNIRGRIVCEKPNSNMESFNGSLKLDAHPRATSLSINNVIFKGSHIKNTEYIFGVILYTGNDTKIMKNISNNKHKLGYVNKELNSYTIIGLIFTFICVFISVLFKWTEDDKFRNGSHFFLITVKDNICESIVKYTLLYSNIIPISILISVDLISILQSILIENDNHISTFENYETSEPSTIDDMDNELGDFKMDKSHTFFKKYTYFLNNRSKNFTNNRYSSTNTERASDFRKSFFGTFDKLKTIKRYFYSIKSKIKSISQSNTLYNKSSAGGSIIRSDKNKQTTFSKSFIDIFQRTNNNEHSQTLDNNNNNDNNNNNNICKEKYQNVNNSKNVYVSEDSSNNKYKQNDYLQKSQEQNEIHSINNNNYNNKNDNNLQTEFSNHNFRINAYKTNRTTKDDTYNNKHISLNSRSKSNQKGILINSNEINRKKKKNLLQKIFPFFKKKRTNISEDLSKYVFRRSKQLNINHNNSEKYNLNDYDEYGWGLCLNSNMHGDLGNVDFIFTDKTGTLTNNNMTFNMCSIAGKTYGSKCKNKKKIYNNPKSNNDNKLNSYDKNIFKNKFSSEASIKKISFVRDFSNNVSSKNDLTLDDPTELISDEGNNYLRDKYEHTSDKKNDTNKNRDGANNSNNNNNKDVSNNKNKNNNNYNYNSNNDYIKQNGECNIYNNQNNTNNTHNNNIYYDEYNNTNEGNMKNTNVNKDTNSKCNKKDFIINTSDIINNNNNNNNDQKTNNLKYKSSSSWNSKAKKSSYINLNSYNKYQSFQNSSMLSSSLSSTCSSETEDENGSQLMYYSSSNYDNLDINNDMDSTKTYSHYTEQNYYNSVKDDKDINSEHQRYQQKKTNKQTKNIQQNQCDQWEDNRYTQESIKNQYFFDRNYQTFLMKQNFPRPKSFRLNMNSSSVKGRCDFNDTKIYNDLNSQSWRGYYIDEFFKCMTLCHAVTPFIQFDYIRNKHLTYTNSRSSKGISNNMDRYNINPTTTTTNNNNNNNNINNINNINNNNNNNNNNNNNKQFSCDYMKNRNDIIFETSTDYYANQDNAKRKREKTLFDNVSHCGEIQEYRDNKKYRMKRSQTCSNNRKIFSNQRTLYDYRNMNNNLKNKNSYLRNKLKSKIFLDKSYRKRKKSSGTYKGSDICKGIEKKETRRWKRFLHMKGSNNRNIFSRIKDFKSNSIIYNNQDKTNDYKNGYSNNINNNNSNNYTNEKINRSFNKRHSAVSFKQMSKEKLIPINNVLSNRCDVESYPNEELSFSKKKKKNSEIVSFASGKSDIGFEERTDAGIAGKNMELSYNELEKYKYVKHIDSNNKYINNNNNSIHMSHMSSNNNTFESHIYFDAIKYQSSSLDEECLIYSSSFLGYRLVLRNKNTMCIEIDGSFNKWTIIGVNEFTNRRGKMSIVVKPDSMESGSILYVKGSDSSILSLLNLKYSKFLDKKYSRKRRNKNIQKYKQKREEYNELKSKDINIEEFQKSKSLSLKNFKNNTPKVLFGECTLDNNNNNINKNYKYDKNDKHNNNNNNNNNNSNYSYNYLHDSNNLDAMQNQKYSYAYEDKEDYYYTNNGECNKYKERYRRLEKQLRKFSVKGLRSMIFAFRYLSEEETIKYKRMYDDACSSIYNKEQRLEKVAEEFERDLIYLGITGVKNGLQEKVPKTIDILNQSGIRIWMLTGDNVEYSLHVSFLCKFLNKHTKIFHAALENSNAKKLKREGMALYELFQLEKEEKKPYENLCLLVNGRNLQTFLNYTDLQTHFLNMACTCDVVIACRITAKQKAFLVQLIKNRLYPTPNTLAIGDGANDIAMIQEANIGVSIMTSDCIISAGYSDYCIKKFCYLRKLLFIYGSKHLYTISIILYWNFFKNILLILPIFFYQAYASWSCVKIYPELLYTFFSIFWVFIPIIYYMFLQHNLNYDILYNIPLFYALSRRRYNMNCFKFLPWIFEAIFYSMIIYFFAYAALKENSHLNNGEVITINTFGNICFIGCLLISILRLFLEGSLWSPSILITCFGCFLFVFFPSLLFICFAYLSNEYIREVFRQTFLWAPLYVLLILWFSTCIISYIFINFTKSILFPNIYNVVNHWLFEQYQEKHNKNKYIFSLSGKNKFLKLRKLGKKIKFKFKRNYSKKYDTNVIREHPLLHHTFKSEQDQNKCNEQFSKDPFISNSLLKSKNCKFKKDSSYSKSNIHVDEEQTYKGLKVVLSEQVVHAKENLVSFKNEKKNKNNKNTSMNVNDNIIIKNNNINIKNNDNNNDDNDNDNNNNNNNNDNYNNNDHNKKEFKQKHIQNNYENLFNHTQVENNLIKENLSIRNDNNRRDNKNETDYIKQSDEDYEMNPSITSLRKRECINDSKYIDNKSYDNKISNNHEEKDGFKSDDRSLINSNMMDYKNEFTENDTTYSFNDSHMFYDFPSNSKTTKDYKVINSRIDDSIMADMKNCLNPLKNTFLVDLLPPGKRFRINEDHIYFKNNERMENIPEALDVNKKYYHIIQNKAEYYDNDSLSEFSYTSSNSSINNKKKNENTQKEIVKVSHLINRFTLAFKDMQLESGFQIHKKNKFYKTFTPWYRFIFLLLGVFFLYVWKLESSLSQLWNMPSDASTDVFILFLSLLLELVLLAATVTTFFSNIFIENFNKIISAVVILIITYHVVSYSVTHIDGVFQAVLFPLYTFVILRLPFVNAVLCNIIFLGLFIIRFNGDHFLDKKGLAHYIPLFIGVDVFVGFVGYRLEYNQRKNFLLEYSVESSRRKQREILNTMLPPFVVDEMIYSELNEEGIPISLKAEDISTVTIIFCDIYDFQNIVASIEPTRLVEVLDRLFLCFDKCTEQFNCTKIETVFETYLAACGLVKREKDEDELENNKYSNNNKNNNNNYYYNRKKKKKKNNNNNNNNNNNNNNNNNNNNNLNNNNNNNNVNTSDDDGDFFEEDDANNHQIYNQMKGQEDAHDSIDFALSILHVSSHIKYEKSKMMLKKNDSFEDANDDTHNVNDSFNNDKAENDNTNTDNNKPTRIRVKVGIHSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYNLVKDDKTLIYEKKETEIKGKGIMTTYLLTSVIGLNYPFLGEHVEKKGHFISELYEDDLSNNLNYDKTQNILGYYSNKINQNNDSNINEGIINNNMNTFNTIDGDTSNYYVNLKDLSLNDLPNEYIKDVNTHYCEIIKLRNLKIGTAVGYQLKQKDFYNMTFLNNGLNNDTATNFNQYIESHKDFDDIKDLRIGMNKLSISDSLYYLNENVIRNEPINEYKNKIKINSVNTNKKSYEDAHLNAGNIIYTNNEYPNGQNIEEDDDLLLTNHYNKTNVNNNNNNNIYDVSKELIEHNEEDYKNILMCSKRCKNCNETYCTPNDCNNNDHVYHVMYHRKLSNIKKNYLKNIRKDANIKKDIEKEELNKIHSNKKSFNFFYLFSYIFKIFPFIGKINKEEKKNKSYKKGEQDKSSKRIIALNSEWIFLKFSDKNLEAKYRAHFYSNKSNINSIEQALIIFLVTFVMQTLISSTVSIVFIDHKRATQTLHINYFAYWSVRSVYTFFGFVLWLLFHYRTRPEVSSLLNIKWMIFFLNLLFISAACVFSIAYLWAISETDQTTSYTIWMTNDTIEFFFYLVILHHNTGMLFQTCILVDLLFITMSLTFIATSVVKTITTDSTVLLIPWYVAFNLISTYCKESIDRRTFYANESAKKTENRATELLNDMLPKHVLEEFQQDKLKLAYTHDRLTFLFADICGFTSWANGVDASEVLTLLQKLFAKFDNDSTKYGLYKLCTIGDAYVAISEPVTEDNKDYDPVDGTERVLEMAYSMIRIIKEIREKLYIPNLNMRIGLHYGSCVGGVIGSGRLRYDLWGIDVLTGNLMESNGIPGKINVSETLKNFLLQQFKNRFIFKPHTTIRVIYKDVKCFIITDKKEVESSNHSKLLQNKNYLLNKKFSTQNYLVKNIFAKKKHSSISSSKNIHSYDEKKKKKNDLFYINVNDRQSNL