lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose).
Sequence:
QGVNIYNISAGTSVDLAAPVTTGDIVTFFSSALNLNAGAGNPNNTTLNLFAENGAYLLHIAFRLQENVIIFNSRQPDGPWLVEQRVSDVANQFAGIDGKAMVTVFDHGDKYQVVINEKTVIQYTKQISGLTLSLSYNATEETSIFSTVVEAVTYTGLA
The following text describes a protein:
Function:
Induces hypersensitive response (HR).
Subcellular Localization:
Secreted. Note=Secreted via type III secretion system (T3SS).
Sequence:
MSPAQIIRTPHSFPPSFTGTSSSAENSHAQSPQQVLTRAFVASGELNAAFGRTSTASEQDFTSLLGTLQRELERKTLSFPDIAELANQLAEAAKGDQGGHWLGRDEQQTLKGMIDRCKSQLAHTHASDASYDPLAQVCENLKTARLHQSISQMTGEAHAKVRGVPDLLALIQLDPDVLAEKPVGMTSYVNFGSFICMAKARTAELSEDLRSDPNEVALLLHPHADTILELERLPDALAALTENCPDTPTRDDLRSLAKETGELLQQLRANDLLPRSEEVSSYQGETSVRSREVVEPKLTLCQAGGNGQGQLEASSARPESLRYAPTRAASSGSEARVPGQAVGGKIADDAQKVAGLYAEKKRTNWTQANGVAGKISHKIQSLLGMRDAGSRVQAFVAFMADGKGRPGATMLDLGDGWMRATRVIKGEAALIDFQCDSDGKVVDARHPGRFPVLPQGNEREAFKTVLQELKFRGAETLSKVPVYYVNRNTRGYVIPTHGYVVAGHPNRGRKSGAVLYGVGGDPKRGPVALDEKLLGHLVGRSDSKTSSKLSAPVKAAISALAGASFATREDFYDAYCAVRGDAVDPLERHNEISSIYRLLPLSTMEMWPKKADDYRVARPAAPERDLRAFENLPKDIGRKAQLKKVSNVDSIDLLEAKRQFTLHQLYQDEMLGRNGTGVPSADFKPKVDAQRRDQLVASTPKFQRLPPHTTDKVGNCNTGASSLLQRAVDTYTEKNNLPPEKVTAASIFGIGSSHRLAIWDPLDGSSSNKSSKDR
The following text describes a protein:
Function:
Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Very weak inhibitor of the endogenous nicotinic acetylcholine receptors (nAChR) in the human rhabdomyosarcoma TE 671 cell line. This neurotoxin is lethal to zebrafish by injection at the back of the dorsolateral region, but is not toxic to mice by intraperitoneal injection.
Subcellular Localization:
Secreted.
Sequence:
LTCHTCPYNTCANSETCPAGKNICYQKKWEEHRGERIERSCVANCPEFESSHTSLLCCTTANCD
The following text describes a protein:
Function:
Insecticidal toxin. Binds to site 4 of insect voltage-gated sodium channel (Nav) and inhibits channel inactivation. In vivo, it lethal to lepidopteran larvae. Has no adverse affects when intracerebroventricularly injected in mice at a dose of 0.2 ug, but causes reversible paralysis of legs when injected intracerebroventricularly in mice at a dose of 2.0 ug.
Subcellular Localization:
Secreted.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
ACVGDGQRCASWSGPYCCDGYYCSCRSMPYCRCRNNS
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MARPILQPLRACSNPVFSCSLQKSILATITAVSQQPHRRQPAAFRSRLHAHRPYHSRHHPELPPHEYTNSQTTILAAALKHVPSHGFTKDALTLGARDTGFLDVSVQLLPRGEFDLILFWLASRRGLLRAAVEQSGLLTTASPVSVEDKTKALIMERLRMNKDIRHQWQDALALMSYPSNIPLSLSELHALSSDILHLAGDSSVDASWYTKRLSVSAIYASAEVIMTRDSSPDLSATEAFVTRRVEDSKAIGDKLSGAKQCLGFMGSTAVGLGRSWGLKI
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that can catalyze both the mono- and symmetric (type II) dimethylation of the guanidino nitrogens of arginine residues in target proteins. Involved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation. Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20.
Miscellaneous:
MISCELLANEOUS: Present with 1180 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud neck. Note=Associates with the septin ring of the bud neck during cell division.
Sequence:
MHSNVFVGVKPGFNHKQHSKKSRFLENVSSHSPELPSNYDYVLLPITTPRYKEIVGQVFKDFQRQSIQNWKPLQIPEPQLQDICIPPFNVKKLDNDDTPSYIGLLSSWLELESRDPNVRDLGLKVLLNECKYARFVGINKLILAPPRDLSNLQLYGQMIYRLLQNRIVFAAPALTISISLPLYEDSDPLATWELWNTVRKQCEYHPSLTISLALPRTRTPSYVLNRWLAEPVSCLLVSSSIFASNQYDYPVLHKFNQNLILKFQKVNGDSQILGNELCVILHGMEKYANNVKGGESAYLEYINYLLKKGDKVLNSNSNHQFLLQEDSRIMPPLKPHSDNLLNSTYLTFEKDLVKYDLYESAILEALQDLAPRASAKRPLVILVAGAGRGPLVDRTFKIISMLFMDSKVSIIAIEKNPQAYLYLQKRNFDCWDNRVKLIKEDMTKWQINEPSEKRIQIDLCISELLGSFGCNELSPECLWSIEKYHSHNDTIFIPRSYSSYIAPISSPLFYQKLSQTNRSLEAPWIVHRVPYCILSSRVNEVWRFEHPMAQKDTVQDEDDFTVEFSQSSLNEFKIKHRGEIHGFIGFFSANLYNNIFLSTLPNDSTVRLKFSEETLMNTRREENLIKKCDHTPNMTSWSPIIFPLKQPISFIDDSELSVLMSRIHSDTEQKVWYEWSLESFIYLMLSNYTSAVTAASMTIPRSIVTDDTKTLAHNRHYSATTNQKLDNQIDLDQDIENEEEQGFLSNLETGWQSVQDIHGLSETAKPDHLDSINKPMFDLKSTKALEPSNELPRHEDLEEDVPEVHVRVKTSVSTLHNVCGRAFSLPL
The following text describes a protein:
Function:
Regulates myosin phosphatase activity.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MGDAAVAKRREQLTRWSGSSTDKEPAVPRSRWRGETSTRAPDGGRPDTNERQKKNRWRVTFEKTAEFLAVCASGDTEEAKAMLREVLLNGEDDVVNCANADGITALHQACIDGSMEMVDFLLSHGANVNQVDSEGWTPLHVAASCGNLEIAEFLLQHGASLCSVNCDGDVPLDIAKDEDTQMLLQKHILKQGMDLEAAKRAEEEWIMHDARHWLTDGLPANLCQPRTGATPLHVAAAKGYLEAIKLLCQCGLDVSAKDCDGWTPLHAAAHWGQSDACRLLAEQLCDMEAHSNRGQSPFDVADESVASLLEELSKRQANWRTEQQNSQTSNVNPANKKRRSSVCRMSSKDKISVQDQSKERGVSGELELSDERESSPESSTVSSPESTVPSSGTTEEKEVKANDQDRASRTAVVPPTPQKRESPAESPSNTSGDGRKYQAPVRDEESEFQRKARSRLMRQSRRSTQGVTLTDLKEAERSIVKDNEPQHVSVQPVSPNVTVTPAERDTDPERESLEAQTKLGVRDRRKGRKERRSTGVVQLAEENDDMDANEDAQQDNNARDHQLDDSIHSSLDYRKLYLRVLQENGNLKEKLQETQLQLNESKVQLEKLKQNQENGSDRPALLELERYEKKLLQRRAFELEDELKVLVDLRADNQRLKDENAALIRVISKLSK
The following text describes a protein:
Function:
Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
Subcellular Localization:
Mitochondrion. Mitochondrion intermembrane space.
Sequence:
MAAPSMKERQACWGARDLYWRCLDDNAEDAARCQKLRSSFEASCPQQWIKYFDKRRDYLKFKEKFEAGGFQSSQSTENS
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MASTTALQARVHKLLGSRAELEATKALLRTLVTDKASSGASLVQLDATPTLAALRRNLRSNLEQQQLALAQKALDGLEGTLAQVSNLATQVDALDDKCDHVHKFLETTKRDTQQVQTEAAALASKRNKVQDEWKEAKTFLDRYQLTEDEVRALYAENLADQDMDAFFSTLERVQQVKADCKELVATGEVNCGLELLDAVGKYQEAGFERLYQWTAKKCAEVDGEPSNMLHRAIALLSDRAEFYNYCKECLTSSRRSLIVRRFIMALTVGGPNGIPRPIEMHAHDPVRYCGDMLAWVHQAIATESEFFRVLFDGDVEFSPSVESSSHGTDVPSSGDISLPVEGSTNGATEVCTSMVGRAFDGVARPLQVRVEQTLSSPHGIVIAYKLVHLLAFYHHKLDQLVAHAEVARALRHCREAANDAFRRQFQQLVDAVAASAQDYAASLAATHVTLDVSHRLVALLEVFQTSLLPEQEKEAGLAPLFDGVLPAVELMCQRSVTGLDPVDALVFRLNNFGCLQTPLARFPEVAKWHAEMGRELDRWLRDLSELQATRVMDRCRVSALLQHILEFQQSHAAVALDADTSPADTPGLDGETITRVMGDFCAALLTLMFPQLDSLGQPALADKARALTAATLAGTYAFVYEFVYDTRNGYIPGSEPTPSSSSWASAERSRRVVLQHTPEEIRTVLELDGETNRDHTLNRRGSKRSLLYLGSAHRLRVFMPVLPVSKAKEVTARAFEELQLPVGASEEQVVSRFRSVCLNQVLNRLPAETSVGASDPGVKTLAAADDGDERFQRQAVAYRFLSSLPLLAGVEYRAEHILPTLRPLDSDHGANERASAMLDVSIATMERAQQAGRLPYTNFVLRVHYCLRRHVVRRRYSEFLALHSLLETKLPVLPQLPERNWVYALKMPPAERARRLVSYLQRVTTLLAARGVFSLEVMAFLEIGATRVRGEEEALAVDVLSRASRGGGDNIFFVVHSSWISAWKRFVTTQKLPPGPIGNHNLLEAPTPESSSRRPKEGLVAAKHYRCVNGSTWRYWHVIYGGGPAIRRQTPSIYGYPACDLATLAVLVQRLVRGFLARRAMRRARIQQKLQDPATAQTVAAKARHRTLEARLDIVRQYVEVREFQTRHIAAMKIQRAFRVFLLRAEHALLLAESAVPDSATTQGLQQIYDDRLALEELALVEDPALRLAHFLATMLAGVPMRKLRSRHKIPAWRLFRLDSIASELRWSSSASAKTNAMAFVDVEKLSVEAPLVTKGPSLARRGVVRELMLICEGSSEMEVLYFGLSALISEVSSRTANGATFVDGHGIIRKRVPHAKKLLREAHTLLEQQRQHKN
The following text describes a protein:
Function:
Protein kinase which regulates promastigote proliferation in host macrophages, thereby playing an essential role in parasite virulence.
Subcellular Localization:
Cytoplasm, cytosol. Cell projection, cilium, flagellum. Nucleus.
Sequence:
MPPKRPQALEKLHVEPHDKGVSITDTMTLVVKGEGGVEMRVKQTGIAQGPGSSSAGGQPKSDAVMNKIKFEDLRIGSELGKGSQGKVRVAQHKLTGEKYAMKYIAFDGDSDDMRSALEAELRQVAAVKHHNVVSSYEAFFRDGRLYIVLEYMDCGTMNNLIDRHPEGFSEDMLAYIARELFKGLEFLHHLNMIHRDIKPANVLANTKGEIKISDFGVAKTLSGGDLQTLSAQGSVPYMSPERIQSKPYSFNSDIWSAGLTIAECAFREYPFASLKPKLFELCQAIASGTAKINWDDRETKFSDEFKEFIELCLRPEATRPSATEMLSHSLIQKASNVNPLEAGRWMSRKK
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein. Peroxisome membrane.
Sequence:
MASPESKSSPKDEQGSPTEVPLNPEPRQQMIETAVKFLQNPRVRQSAFTQRRAFLQKKGLTNEEIQLAIEKSGTAADETNPPPPPPTQVVQSTAPVALQPPVIVPVSPWSKWRDMGAVIVLVGGALYGLYRLFQAYLLPLWKSRDEERQRLERIEAAVTELTASVNKTVGELQQTLTKQGDRVQEISMELAAGKSTARVFESQSVSELKAEITSLKGLLLSRHQFPPTPSPTPIIPSWQMETVDSASSTSGKAATTSSEVSPAEPAPPGKDADSNIESESLDVTQNGLSAEKNVSTSESSEDTSSSIVHVSNPLDELSSGEEMEAKCQMEGKGQEEESTAEVSQGEEDNQENTEMKQV
The following text describes a protein:
Function:
Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MTENALLLLNLGSPDSTRVEDVRRYLDQFLMDPYVVDLPWPLRRLLVSLILIKRPAESAHAYSSIWWDEGSPLIVLSRRLQEAMKPHWPHGPVELAMRYGQPAIEKVLLDLARRGIRRVTLAPLYPQFADSTTTTAEQEVRRVIAAHRLGLEVSTLPPFYDQPVYLDALVESVRPYLQQPHDHLLLSFHGLPERHIRKLVKDPAHDLLAENSRNVSPEALALCYRSQCLRTAEAFAERAGLEQGRWSVSFQSRLGRAKWIEPYTDAKLDELVQRGVKRLLVMCPAFVADCIETLEEIGMRGREQFISAGGEDLVLIPCLNDHPAWVGALAEMSGRLARPL
The following text describes a protein:
Function:
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
Sequence:
MNAAAVEVLKDLPDLAIAYGVSDEYSFVFHPTCELFERRSAKLVTTIVSTFTAHYIYLWGNYFPDTPLQPPHLPSFDGRAVVYPTIRNLRDYMSWRQVDCHINNLYNTTFWMMVLKGGMSNTDAENELKGTLSSDKNEILFKRFGINYNNEEEIYKKGSVVYRQYQLEERKPLKAPEEEGPTVQESISKSQQEKLRKLRRKAQVIVEHVDIIKDEFWERRPWILSGKPGRLPAEA
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MASSAAVPFWRAAGMTYITYSNICANLVRNCLKEPFKEEALSREKVHFSISKWADGKPEKPILRSDTPGV
The following text describes a protein:
Function:
Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein.
Sequence:
MNLQWDLNYTTSSINMTIEVRNIMLGGSYSFGFGFSDDENMGDGDLIVVRVTRTSVAIKDCWLYTNGKVVEDSKHSYKLLGYQYSNGVWNIKVERKFQTCDGEDYQLDNGTTNVFVVFPIPNNCILSINGNGCNLSEATKTLTRVQLLKADYRDIPLEPNHKSFSIIAPNITIPTSQTSYVCSIQKLPKFRTKVHAIGFESVIANPGLVHHIEVFMCDANDKYIPQYVGLCDGREVTDAMTCSHVVAAWAFGADPFYYPREAGMAFGVKTASSYVRLEVHYNNPMHIRGLVDGSGIRFHFTENLRPHDLGIMEVGVIYSANMAIPPGQKSFKWSGECPGSCTQADAIASAGIDIIKGLEVFTNEYRKLRLFIHIFQGDSLITTCTFNTENRSNITLGGLGLHEEMCVDYIYYYPATNLEVCKSSISSQALEMYFKLIKLIKNRSLGIPRPRNSRPLHHEYDVIKWGNSAVRSLRQLYRFAPMQVNCLRSNGESYPGRWDNITPATHFPRAME
The following text describes a protein:
Function:
Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus (By similarity); Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. Relocalization from the cytoplasm into the nucleus is mediated by TRN1 (By similarity).
Sequence:
MDSDQGKLFVGGISWETDEDKLREHFTNYGEVSQAIVMRDKLTGRPRGFGFVIFSDPSVLDRVLQEKHSIDTREVDVKRAMSREEQQVSGRTGNLNTSRSSGGDAYNKTKKIFVGGLPPTLTDEEFRQYFEVYGPVTDVAIMYDQATNRPRGFGFVSFDSEDAVDSVLHKTFHDLSGKQVEVKRALPKDANPGGGGRSMGGGGSGGYQGYGGNESSYDGRMDSNRFLQHQSVGNGLPSYGSSGYGAGYGNGSNGAGYGAYGGYTGSAGGYGAGATAGYGATNIPGAGYGSSTGVAPRNSWDTPASSGYGNPGYGSGAAHSGYGVPGAAPPTQSPSGYSNQGYGYGGYSGSDSGYGNQAAYGVVGGRPSGGGSNNPGSGGYMGGGYGDGSWRSDPSQGYGGGYNDGQGRQGQ
The following text describes a protein:
Function:
Morphogenic protein required for the assembly of the outer coat of the endospore. Is also a regulatory protein for the expression of cotA, cotB, cotC, cotH and other genes encoding spore outer coat proteins.
Subcellular Localization:
Spore coat. Note=Localizes between the two coat layers in the mature spore.
Sequence:
MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHKYDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHEVIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWEDELDEELEDINPEFLVGDPEE
The following text describes a protein:
Function:
Involved in RNA-directed DNA methylation (RdDM). Required for the silencing of some endogenous RdDM targets and accumulation of 24-nt siRNAs, but not for the production of Pol V-dependent transcripts. Functions in transcriptional silencing through both DNA methylation-dependent and -independent pathways. Required for both maintenance and de-novo DNA methylation. Plays a role in the recruitment of Pol IV to genomic regions associated with K9 methylated histone H3 that are targets for RdDM.
Miscellaneous:
MISCELLANEOUS: Associates in vivo with Pol IV but not with Pol V and this interaction is not dependent on its H3K9me binding activity. Glu-130 and Asp-141 interact with the H3K4 side chain while the H3K9me1/2/3 side chains insert into a hydrophobic aromatic cage formed by Tyr-140, Phe-162 and Phe-165.
Subcellular Localization:
Nucleus.
Domain:
The SAWADEE domain (138-244) binds to mono-, di-, or trimethylated H3K9 histone peptides, but this interaction is impaired if H3K4me2/3 methylation is present.
Sequence:
MAASDDSSHYFTEFTLSEIVDMENLYKELGDQSLHKDFCQTVASTFSCSVNRNGKSSITWKQVQIWFQEKLKHQSQPKSKTLPSPPLQIHDLSNPSSYASNASNATFVGNSTFVQTRKGKASDLADLAFEAKSARDYAWYDVSSFLTYRVLRTGELEVRVRFSGFDNRHDEWVNVKTSVRERSIPVEPSECGRVNVGDLLLCFQEREDQALYCDGHVLNIKRGIHDHARCNCVFLVRYELDNTEESLGLERICRRPEE
The following text describes a protein:
Function:
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein.
Sequence:
MDIGVMPNATILVQLFIFVIFLMIITNIYVKPYTAVIESREELIKKNLSEAQKLREETQTYLTQAKEVLEDAKKRADQIIENARREAEAQARSIIEQTEKQTEEEIKKAVEEIRTSLEEEKKKLEKSVKEIAQEIVKKILREAA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MASTIAAATKVSRKMFRELHGVVVTSGLIDKTVKVRVGGQKFNKFLQKHFDDPKQYLVHDPNNSLRAGDVVAIMPGFITSKSKRHVVKHIIAPAGTPIEERPPIPSLDELWDAKDAAKAAKKERKVLREKMQAAEEAIELAERMARHAVREIAMREKIISLQKVD
The following text describes a protein:
Function:
May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Domain:
Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
Sequence:
MASVNANVNLTSQLASHIVVPLTTFLNGNNTLFSESQPWISDLRCSHAALDSDTNCDRFKLHLPYSQHTLIWEVIFDRRRNNQAPDFIFGEEDKDFNPDSEKLEEKLLGANSRLSFECSKLRTSKDFDSFEILVKKKNTNGYNSYFEANFLIRINLKSESLPHLKADKINRIGENFTRRKELIESFKQHFNGALLEYDSENYTSINLLLVTSGFYFILHVSLPSGFPQSMPVLIIQSVYHRMGILPYKETRTSYPYSPRWSGKEMVERIQVYLATIIEDFKTSSLRYGKL
The following text describes a protein:
Function:
Involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the oxidation of dihydro form of MAP (H2MAP) to yield MAP.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIIQRLFGILYMLAGLAKAFPQFENVPAVLRQAAIANQGTWYAAASIWLGAHGDVINILVGVVLFGSGVILMLNPLWTTLVIYAQLLMMAVFVVILHQSQPQVMLLDGVFALAALYMLRGQYHRKPKPRTFPTTSFSLPTPSSESSFSAPLGDEYDVVIIGGGASGLTAASEFTHERVLVLEKSSTFGGNARYHTFNRLKHPTAGVCFQEPFPGSNMLRLLKKIGLEGKYKSNEKDTLVFFDTFLLLKCLGEIVVGFIKQPRYLLKLSVWGLTSQLFLHAIIGKPYVVAAKQLGDPIFADLYTFLDKFSPRGDFYPRLPWTPNGSWSKAHMELLDNISLYTYLFEPDKLGRLPEQLRPPARLGKLVENAVSTTLRVECLDIHDVSAYVGLHFLVGYLRGNLVTLPGGNGSISAGLCKYLSHQRNVTLQNHVQLTAVEPQHNGTCIQFTINGQPRQVQAQQIIWAAPKTQLATWLPGLPAKQLAAIKNIRHEDYYLANVFLSKPVLGHSFGGYMIEPDSNKDPFSWCKAGTCLVANWMDDHADVDVGVLTLLKPTTRSERQDRTAQNAFLALQQQTYAEIAKVLRNIGIGAEVIEDIQIWYWPAGLVTSVVGQQAEGVFETARQSFENIHFANQDSVGVGNIESAILSGIDAANAVKAQLMDTENVVEVAG
The following text describes a protein:
Function:
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Subcellular Localization:
Cytoplasm.
Sequence:
MNFKVRVIDLAGSCCRLGALQFGTKVVETPGCLIYNRSGVVPHLTPDILETLDNVPPIMHTPLASIIEEPGLIKLRGYGKGLASFIGYKDNSVYISASDYQGEAMYQYNENKSISVWTKTGRTKVTPDDYSKFVEVCRPSWYQSLCDTVPANASIKRTRKSVDRTLEFLDQCLKYREKHDSLKTSELWAAVEGGGLVDERQRSAKESATRPVFGFTLEGFGSDQMNVETIFELLPLTTQNLPVEKPRLIHAIGSPTINSLSRSSKLTEVEEENGNDSSNDQDRTATFSLLNLREDRYNEDFSPLVSGCKCFVCSNHTRAYIHHLIINNEMLGGVLLMTHNLFQYIEFFRCIRTSLKNNKWKELRKLFDA
The following text describes a protein:
Function:
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MGDEDWEAEIIKPHISSYVPVFEKDRYSSGANGDTFNRTPASSSEMGDGSSRRDHFMRSGFASGRSLGNRDPGESNKRENTSTVGGFGVGKSFGNRGFSNNKFEEGDSSGFWRESSIDCEDNQTRNRGFSKRGGYQDGNDSEALGSSRRGGRGSFRGCRGGFGRGSPNSDYEQDEGTQRSGGIFGSRRSALSGAGNGDTFQSRSGGGSGRGGYKGLNEEVITGSGKNSWKSEAEGGESGDTQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDPPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIIQGGRDLMACAQTGSGKTAAFLLPILAHMMRDGITASRFKELQEPECIIVAPTRELINQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDVIGKEKIGLRQVKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAGEFLKSNYLFVAVGQVGGACRDVQQTILQVGQYSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDSQLAQPLVKVLSDAQQDVPAWLEEIAFSTYGPGFSGNARGNVFASVDTRKNYPGKSSLNTAGFSSTQAPNPVDDESWD
The following text describes a protein:
Function:
Binds anionic lipids and gangliosides at acidic pH.
Sequence:
MKLLLLIVFCGLAYGQEENGCAAPGYFQARLRSFDHENEFFRDGKFSYDAYEQRERMVEVFSEDATRPQRDELILHKEKKRYVVDLKTGECDVTAIDYDFHAIEVHEPAQFIGFSTVGSLDEPDMGMMLASWHHHHHEEGNWTQTFTRYECIPVTEVFSGETVDDHQTIHFHKTYFDVTVGLDSPDVFDVPQACIS
The following text describes a protein:
Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRSLPNIVITGTPGTGKSSHCDTLASELPDMKVFSINQVAKDRDCFDGYDEERKSHIVDEEKLIDAIEPDLEKGGLIIDWHVCDIFPEDLVDLVIVLRADTEKIYDRLQKRNYAETKLQENLDAEIMEVVLSDARESYAEEVVIELPSNTIDDIDSNVSRIVSWKEQWVADNK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MAPPVVLRSFSRLLAPARLPSCSSTRSKFYVREPVNAKPNWVKVGLTLGTSIFMWIYLIHQHNEDVLEYKRRNGLE