lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development.
Subcellular Localization:
Nucleus.
Sequence:
MRVGVSESEDSDGHVIEDEDLEMARQIENERKEKRAQKLKEKREREGKPPPKKRPAKKRKASSSEEDDDDEEESPRKSSKKSRKRAKSESESDESDEEEDRKKSKSKKKVDQKKKEKSKKKRTTSSSEDEDSDEEREQKSKKKSKKTKKQTSSESSEESEEERKVKKSKKNKEKSVKKRAETSEESDEDEKPSKKSKKGLKKKAKSESESESEDEKEVKKSKKKSKKVVKKESESEDEAPEKKKTEKRKRSKTSSEESSESEKSDEEEEEKESSPKPKKKKPLAVKKLSSDEESEESDVEVLPQKKKRGAVTLISDSEDEKDQKSESEASDVEEKVSKKKAKKQESSESGSDSSEGSITVNRKSKKKEKPEKKKKGIIMDSSKLQKETIDAERAEKERRKRLEKKQKEFNGIVLEEGEDLTEMLTGTSSQRKLKSVVLDPDSSTVDEESKKPVEVHNSLVRILKPHQAHGIQFMYDCACESLDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEKCKRVLVVVPKNVIINWFKEFQKWLVDNDEELDTIDVNELDSYKTIEDRRRALKAWHSSKTPSVMIIGYDLFRILTVEDDPKKKKPKNRNRRLEKAKEDFRKYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDASPLEVSFMKRRCHVLYDHLKKCVDRKDYRVLTEAIPPKQEYVINVRQTERQCALYNAFLNDIVGDSGLSKRLLPDYHMFSRIWTHPYQLVLHEQRMERERVMREDAEEEADFIDDGDGSESESEGSFKSGSESDSGKSVVLSSDDEGSSKKKKNGNKPEIKKTAPQKKRKFLNSDDEDEEDGEDTAMAILQDGIRQSKRLAGEEADLRDTDTPPEYTGWFARLGLVKEEDRDDFALSNKLILLVEIIKKCEEIGDKLLVFSQSLESLTLIKRMLEYMAGTGQWFADGHEALNAEGEETWSWLEGEDYMTIDGSVQSGKRDAVQTSFNDPLNLRARLMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFGQTKPVYIYRFIAQGTMEERIYKRQVTKESTSMRVVDEAQIQRHYLGNDLTELYQFTPSTFDPDVEISCAPPKDRLLADVIHKNQHAVVDYIEHDTLFANVEDEKLTEQEMKDAWTDYEKDKSGMPVRAQYAAPPMPGFPNGMIVGQNVQALLQNRMNQGIRVDQMQHDILFKELQKMRIKDAGTAVKIVLLRNLLEQILPYIPDEMRGGMSEFNTHFIRLVHETDRKMETPADLLRKSLESFKTVIKMVKMIPTCREPLARMTRDYPYLFA
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MRIDFKLLSCDPLTPPSSPPLDPEKDTNQKAREKQLKPPSPSDQDTKLAQVLDVEAIPISEPATFSLPKPVFDNWFPYGYDRPLKQNYKTPTPITSFSYDQDAKIRCGLDQFVSLRPFLESAKHIGFDLNTGIDEAEYVDELQKAVDRGIDGLLLSLADFLDRSHPDHQISISREILSTELITWRSTLAKLTLTAYETTPTGRNPSGIWTKRVMMVDGTIYIEDETGIEDVENLDELMDRGYVEEGGVIQPSHDWAVQIYHGYSYQSLLTNQEFQPVNRKPRWISVVRSNLNGIPIILGGEVDCVSSECFQEIQTPDPTNHHDHQEAVDDNHHVVQKVVPPDQTIELKTFILPSTTRQYAHLYRYKMLKFWLQSFLMGTPKVHVGFRIREGILDRSTTYQTNEIPELVNRNAKPCCRWSGEVCLQNGTKIVQFIQDKLAPTVKGKPSLQRPDQARQAYRKNTNPIWQARKNTNPTPTSSTTTSQAYPNRSKFFQDRLDAIVAEEFERQVNVRREDSGLRQSGSCRLSELCKAQVRDLDRWPAYRLAFHPYLGRKDPHSHDQAHPPSCFELVELSFDEVSKSILSNKPKNLFDDGNPSSLSSSSTDVSTDHQDQEITDREQDRSSAHRVGFLPLFWVQRVVQMRLDVLLSKHNM
The following text describes a protein:
Function:
Required the formation of the callose wall separating the tetraspores (interstitial wall), but not for the callose wall surrounding the pollen mother cells (peripheral wall). Functionally redudant to CALS12 (GSL5). During plant growth and development, callose is found as a transitory component of the cell plate in dividing cells, is a major component of pollen mother cell walls and pollen tubes, and is found as a structural component of plasmodesmatal canals.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRRQRPSVATARDAPSLEVYNIIPIHDFLTEHPSLRYPEVRAAAAALRIVGDLPKPPFADFTPRMDLMDWLGLLFGFQIDNVRNQRENLVLHLANSQMRLQPPPRHPDGLDPTVLRRFRKKLLRNYTNWCSFLGVRCHVTSPIQSRHQTNAVLNLRRELLYVALYLLIWGESANLRFMPECLCYIFHHMAMELNKVLAGEFDDMTGMPYWPSFSGDCAFLKSVVMPIYKTVKTEVESSNNGTKPHSAWRNYDDINEYFWSKRALKSLKWPLDYTSNFFDTTPKSSRVGKTGFVEQRSFWNVYRSFDRLWILLLLYLQAAIIVATSDVKFPWQDRDVEVALLTVFISWAGLRLLQSVLDASTQYSLVSRETYWLFIRLTLKFVVAVAWTVLFSVFYARIWSQKNKDGVWSRAANERVVTFLKVVFVYVIPELLALVLFIVPCIRNWVEELNLGVVYFLTWWFYSKTFVGRGMREGLVDNVKYTLFWIIVLATKFIFSYFLQIRPLIAPTRALLNLKDATYNWHEFFGSTHRIAVGMLWLPVILVYLMDLQIWYSIYSSLVGATIGLFSHLGEIRNIDQLRLRFQFFSSAMQFNLKPEEHLLSPKATMLKKARDAIHRLKLRYGIGQPFNKIESSQVEATWFALIWNEIILTFREEDLISDREVELLELPPNCWNIRVIRWPCFLLCNELLLALSQANELCDAPDHWLWSKICSSEYRRCAVMEAFDSIKFVILKIVKNGTEEESILNRLFMEIDENVENEKITEVYKLTVLLRIHEKLISLLERLMDPEKKVFRIVNILQALYELCAWEFPKTRRSTPQLRQLGLAPISLEADTELLFVNAINLPPLDDVVFYRQIRRVHTILTSRDPMHNVPKNIEARERLAFFSNSLFMTMPQAPSVEKMMAFSVLTPYYDEEVMYRQEMLRAENEDGISTLFYLQRIYEDEWVNFLERMRREGAENENDIWSKKVRDLRLWASYRGQTLSRTVRGMMYYYSALKKLAFLDSASEMDIRMGTQIAPEARRSYYTNDGGDNTLQPTPSQEISRMASGITHLLKGSEYGSAMMKFTYVVACQVYGQHKARGDHRAEEILFLMKNHDALRIAYVDEVDLGRGEVEYYSVLVKFDQQLQREVEIYRIRLPGPLKLGEGKPENQNHALIFTRGDAIQTIDMNQDNHFEEALKMRNLLESFKTYYGIRKPTILGVREKVFTGSVSSLAWFMSAQETSFVTLGQRVLANPLKVRMHYGHPDVFDRFWFVPRGGISKASRVINISEDIFAGFNCTLRGGNVTHHEYIQVGKGRDVGLNQISMFEAKVASGNGEQALSRDVYRLGHRLDFFRMLSFFYTTVGYYFNTMLIVFTVYAFLWGRLYLALSGVEKIAKDRSSSNEALGAILNQQFIIQLGLFTALPMILENSLERGFLPAVWDFITMQLQLASFFYTFSMGTRTHYFGRTILHGGAKYRATGRGFVVEHKKFAENYRLYARTHFIKAIELAIILLVYAAYSPLAKSSFVYILMTISSWFLITSWIISPFLFNPSGFDWLKTVNDFDDFIAWLWSRGGLFTKADQSWFTWWNEEQEHLKTTGVWGKLLEIILDLRFFFFQYSIVYHLRIAENRTSIGVYLISWGCIIGIVAIYITTIYAQKRYSVKEHIKYRFIQFLVILLTVLVVVMMLQFTKLTVVDLLISLLAFVPTGWGLISIAQVLKPFLLSTVVWDTVISVARFYDLFFGLIVMAPVALLSWLPGFQNMQTRILFNEAFSRGLQISIILAGKKST
The following text describes a protein:
Function:
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Subcellular Localization:
Cytoplasm.
Domain:
The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation.
Sequence:
MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADAGLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSSSQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI
The following text describes a protein:
Function:
Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTKEAEPEKRSPFGVEAPISNGYLTVEGQQEDKRANGTCQASVIGEPLPHEASDGAAAVGNCDKPQPGGEEEESQARLLPLRFGGSDGGEVEAEAEADAGERSLGGRTALTPRRFVVLLIFCLYSLVNAFQWIQYGIISNVFQDFYGVTSLHIDWLSMVYMLFYIPLIFPATWLLDTRGLRLTALLGSGFNALGAWIKCASVAKDRYWVTMLGQCLCSIAQVFVLGLPSRLASVWFGPKEVSTACATAVLGNQLGAAVGFLLPPVLVPNINNTDLMAHNISTMFYGTASISTFLFILAGIAFKEKPRYPPSKSQAVLQDHLPEDYSYKKSIINLFKNIPFVLLLISYGIMTGAFYSLSTLLNQMILAEYKGEEINAGRIGLTLVVAGMVGSILCGLWLDYTKTFKQTTLIVYILSFIGMVIFTFTLDLQRLILVFITGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLISNYGTHAGNLFLCSWMFVGIILTALIKSDLRRHSINLEAKNMDVKAVLVNRSEEPKSRNSILTKQLE
The following text describes a protein:
Function:
Regulates glucokinase (gck) by forming an inactive complex with this enzyme. The affinity of gckr for gck is modulated by fructose metabolites: gckr with bound fructose 6-phosphate has increased affinity for gck, while gckr with bound fructose 1-phosphate has strongly decreased affinity for gck and does not inhibit gck activity.
Subcellular Localization:
Nucleus. Cytoplasm. Mitochondrion.
Domain:
Fructose 1-phosphate and fructose 6-phosphate compete for the same binding site.
Sequence:
MRGTRKYQHVIETPDPGKWELAGYEESLPISEKSNPMTRELDKADPSQLVQLLRDCDAEIFQEEDENLIHYHRLYSESVLKTMGDVAKRVQEVLKNPDDSLVVLSGCGTSGRLALLLANSFNGLLKGLHKTPCYCYIMSGGDRSIVTSQESSEDNPQLGAQELEKVCEGKKNVLFIGISCGLSAPFIAGQLDFCMRHLDVYLPVLVGFNPVSMARNERIEGWHSSFRQVAERLQTLHDSQKGFILNPAVGPEGVSGSSRMKGGSATKILLETLLLVAHKAESNVPVTEKCLLEILRTYERAHKVTYSQSKKIAALMKQTATSLQKKGHLYILGWGTLGLVGIMDAVECVPTYQADWRDVRGFITGGYHSIENKEGDLSSLGPQFSISHEDFVKNVLPSVSETDTVLLIFTLDDDLNQIEKLVALVKEKTSNIQVICHATAGQYLPNSLKKTIPSIIGLTWPILFLEYEGAFIQKFQRELSTKWILDTVTSGAYTLRGKIFRNFMVDFKINNSKLFHRATSVLQRLTGQSHQRCTEVLLQSIYGEQTLSEQIRNTTIAGHVEAAASQDKVLPVAIVSLLRSCTIQDSRSRINSSLSIRSAIESSMNVPGRKRGAEDSESR
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Sequence:
MSSSKKIVILYGSETGNAHDFATILSHRLHRWHFSHTFCSIGDYDPQDILKCRYLFIICSTTGQGELPRNVNALKGERPVTFWSFLKRKNLPSNLLNHIQTAMLGLGDSSYPKFNYGIRKLHQRIVTQLGANELFDRLEADDQAMAGSNKGTGLGIESVYFEYEKKVLSFLLSKYPNRKVNGQIIKREELDPEVYLEPASYLQLSDEHANEKFTSTKVIFEGDESLKVGRVNINKRITSEGHFQDVRQFKFSNVDKIQENYEPGDTVTIYPCNTDEDVSRFLANQSHWLEIADKPLNFTSGVPNDLKDGGLVRPMTLRNLLKYHCDFMSIPRTSFFLKIWTFATDVTKMERGQEQLNDQREKLRQFATDQDMQDLYDYCNRPRRSILEVLEDFISVKLPWKYVLDYLPIIKPRYYSISSGPGDPNIELTVAIVKYKTILRKIRRGICTNYIARLQEGEQIRYKLQNNHIIKKEFLNKPMILVGPGVGLAPLLSVVKAEISKDIKLLFGCRYKDKDYIYKDMLEDWFRKGKIALHSSFSRDEENSPGVKYVQDYLWRLGEEITNLVVNKDAVFFLCGSSGKMPIQVRLTFIEMLKKWGNFSDEETAKKYLKEMEKSDRYIQETW
The following text describes a protein:
Function:
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (By similarity). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (By similarity). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Mitochondrion membrane. Cytoplasm, cell cortex. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS. Colocalizes with MGARP at the mitochondria.
Sequence:
MALAIQLRQPSRAQPLPGLSHTLAGTDSCDVCNSTNLPEVEIISLLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEACQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKSCAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEELESPDITHQKRVFETVRNVNQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDVSNVVLDNKTNSILLETEAADLGNEDHNKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLRELAEKGELHSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLAGLATSTPIQHPETSAHHPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPAPACSSTSHLKSTPVATPCTPRRLSLAESFTNVRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPRMAVIPSTPPNSPMQTPSASPPSFEFKCTSPPYNNFLASKPASSILREVREKRPVRSSESQTDVSVSNLNLVDKVRRFGVARVVNSGRARIPTLTEEQGPLLCGPTGPAQALVPGGLVPEGLPLGCPSGIRRNRSFPTMVGSSVQMRAPVILTSGILMGAKLPKQTSLR
The following text describes a protein:
Function:
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane.
Sequence:
MATPGPVIPEVPFEPSKPPVIEGLSPTVYRNPESFKEKFVRKTRENPVVPIGCLATAAALTYGLYSFHRGNSQRSQLMMRTRIAAQGFTVAAILLGLAVTAMKSRP
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MSIGGLFSIIITSIFINNIIFAKFLGCCPFMGVSKKVDSSLGMGMAVTFVITIASGVTWIVYRKILEPLGLGYLQTIAFILIIASLVQFVEMAIKKTSPSLYKALGVFLPLITTNCAVLGVAIINIQEGYNFIETIVNGFGVAVGFSLALLLLAGIRERLEYANIPKNFKGVPIAFITAGLLAMAFMGFSGMQI
The following text describes a protein:
Function:
Forms the 160 nm long, sixfold helical, rigid tail tube. Binding to the entry receptor triggers structural rearrangements of the tail tube leading to ejection of the phage DNA into the host.
Miscellaneous:
MISCELLANEOUS: [Isoform Tail tube protein gp17.1*]: Produced by ribosomal frameshifting; MISCELLANEOUS: [Isoform Tail tube protein gp17.1]: Produced by conventional translation.
Subcellular Localization:
Virion.
Sequence:
MPETPIMGQDVKYLFQSIDAATGSAPLFPAYQTDGSVSGERELFDEQTKNGRILGPGSVADSGEVTYYGKRGDAGQKAIEDAYQNGKQIKFWRVDTVKNENDKYDAQFGFAYIESREYSDGVEGAVEISISLQVIGELKNGEIDTLPEEIVNVSKGGYDFQQPGQTTGEAPGTVPLPNAPQNLTYTATTDSVTVKWDAVEGADSYNVYRGAEKKLDANVTTTSHTLTGIQPDTQLTVNVAAVNAGGESPMSQIVTKTLPAESTG
The following text describes a protein:
Function:
During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity).
Sequence:
MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLRLPSGNGYKFLSPGRFFPSSKC
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MALASQIISPSQQFLLILRTHSLIHICFFDLRLQMLSRLSSRSIRFFNSISSIELTQHPKAGTCLSVDLSNGKTDTNVQVPLIWFRDHCRSVNAYNHTTNQRKSKMLNLFEESRISDRSAVTYDAKQLSINWADGHKTVFDSADLIKMLVKPQQKQPRDLYHLWNGSTIGPLPTVQNSSFSFPEFSQKFVQFGFVSVEGIEQTPEATEKFARSIAPIHDTYYGAFWTFNNKAEQQENYHEDTAYSNEEIGPHTDGTYFPQSPGIQVFHCLRPADRGGKTVLVDAFAAAERLKAENPSAYQILTTTPIDHHYIEKGENPLFSWAPSKPVIELSADGGYAQIRFNPYDRAPLRLSLNGGKGLSTPEDVTAFYEAYQAFSRICHDPTMAVKIQLMPGTVIFIDNLRVLHARTAFSGYRQMCGCYLSRDNLMAKARLHVGEETRLQV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSEMLVSDKARHLYTKMREYPTSKLFDQDELQTLFDIKKGSELMEYLQELVNGKYVKISKMGDQLKFQTVAEEEAKKVSSMSDDEAMIYSYIEASGREGIWTKTIKAKTNLHQHIVQKCLKNLENNRYIKSIKSVKHPTRKIYMLYNLQPSIDVTGGPWFTDSELDTEFIETLLEVCWRFIVGKTMYIKDEEADNEDINPLQTTYHNHHPGVNLDQLVEFINNSNITSVELGINDIRSLCDVLIYDDRIEEVGGNQENSGIFKATWQSIIDKGNTILQNNYQDLKNVVSEDCFNYLQQNQSDFSVFQYKSTIQDLQDESDLVYLDSWMNE
The following text describes a protein:
Function:
GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT). Plays a dual role as both a protectase and a reactivase for MMUT. Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP.
Sequence:
MFGRSIVFFLSTNTRFLRSSLSLKTSKNLNPVFLNLNAARFCTSSTKASTETSATSITTVDEDGALQFTPNTYRLKLVTFNDSPQYTERPDDHKLNHDSLPANPIVVGSVINRPNVTPDDPVVQEYLNGIKSENRSYLARAITLIESTHPMKRAQGQVLVREVLEYCRRKQKHSLNSAMSFRIGLSGPPGAGKSTHIEALGKMLTKRNHKVAVLAVDPSSSTSGGSLLGDKTRMLQLAVDPNAYIRPSPNSGTLGGVTRVTNDAIVLCEGAGYDIIIVETVGVGQSEFAVADMVDLFELLLPPAGGDELQGIKKGIVEVADMVVINKSDGDLIPAARRIQMEYVSAMKFIRPKTKVWKPCVLRVSSVSKEGMEEMWAKMEEYYKVMSSSGELERLRRRQHVRWMHNHIHDSLVSVFHEIPRVKELIPDLEELVRKGVVTPGQAADKVMRDFIRQIDENLLRYRVPTSSQDDDTSSSSDSSDDDRSEKKDKKKDKVKHELDKLVGKKKDAPRFGYGRTANY
The following text describes a protein:
Function:
Transcriptional repressor. Activity as a repressor is enhanced by binding to the corepressor tle3a.
Subcellular Localization:
Nucleus.
Sequence:
MHEETSNSTLQGKTSFSIADILDPAKFNGTRETREISNNRESPKTTSPTQDPSAPNIANASAAKVKSKRIRTAFTLDQLRILERSFQSSHYLSVFERHCIASALGLSETQVKIWFQNRRTKWKKELDGHGGEEQSHCAPTALTQNPIMYALPGHHANHHVHYYPQQTHYLNTSFHPQTLMMY
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA. Unlike the case in E.coli, suppresses RecA-dependent homologous recombination, is instead required for single-strand annealing pathway repair of DSB.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Domain:
The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC; The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
Sequence:
MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEMLLITFNRAASRELRERVRGQIVEAVGALQGDAPPSGELVEHLLRGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADVELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALALALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATALEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPKQAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATLGHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEALRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNALAEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFGETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRRVLSQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAGPPEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHDDGTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRAQSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTPRVTDEQAWAVFAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSYSDLVRGSEAVTVTSEPAAGGRADEVEIAVVAAPGSGADLTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVRRHAPWWTVDVDHAQLAPELARALLPMHDTPLGPAAAALTLRQIGVRDRLRELDFEMPLAGGDLRGRSPDVSLADVGELLASHLPGDDPLSPYADRLGSAGLGDQPLRGYLAGSIDVVLRLPGQRYLVVDYKTNHLGDTAADYGFERLTEAMLHSDYPLQALLYVVVLHRFLRWRQRDYAPARHLGGVLYLFVRGMCGAATPVTAGHPAGVFTWNPPTALVVALSDLLDRGRLQS
The following text describes a protein:
Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYMILVRAVFITGMLGNMFIGLANCSDWVKNQKITFINFIMVCLAASRISSVLMLFIDATIQELAPHFYYSYRLVKCSDIFWVITDQLSTWLATCLSIFYLFKVAHISHPLFLWFKWRLRGVLVVFLVFSLFLLISYFLLLETLPIWGDIYVTLKNNLTLFSGTIKTTAFQKIIVFDIIYLVPFLVSLASLLLLFLSLVKHSRSLDLISTTSEDSRTKIHKKAMKMLVSFLILFIIHIFFMQLARWLLFLFPMSRPINFILTLNIFALTHSFILILGNSNLRQRAMRILQHLKSQLQELILSLHRFSSLY
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation.
Miscellaneous:
MISCELLANEOUS: Present with 2930 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKVLEERNAFLSDYEVLKFLTDLEKKHLWDQKSLAALKKSRSKGKQNRPYNHPELQGITRNVVNYLSINKNFINQEDEGEERESSGAKDAEKSGISKMSDESFAELMTKLNSFKLFKAEKLQIVNQLPANMVHLYSIVEECDARFDEKTIEEMLEIISGYA