lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
Sequence:
MSKTPLTAKAIDAAQPQDKPYKLTDSLTPGLFLLVHPNGSKYWRFRYWLNKREFLQAIGVYPLITLKEARRRATESRSLIANGINPVEQARKEKAIDALNMAAGFKKVAEDWFATRVGGWSESYAKQVRSALEKDVYPVLGKRSIVDITARDVLALLQKKERTAPEQARKLRRRIGEIFKFAVITELVTRNPVADLDTALKARRPGHNAWIPISEIPAFYKALERAGSVQIQTAIRLLILTALRTAELRLCRWEWINLEDATITLPAEVMKARRPHVVPLSRQAVELLQDQFTRSGYSAFVFPGRFMDKPLSASAILKALERIGYKSIATGHGWRTTFSTALNESGRYSPDWIEIQLAHVPKGIRGVYNQAAYLKQRRAMMQDYADAIDSILAGNGNPLEPE
The following text describes a protein:
Function:
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
Sequence:
GLQPLGRAASRLRGKSGFSLPTLPPVAALNAVPRGVYPSLPELRAAWAGGGTGRGWGGEEGFLRSCVTAGLGAGPGVPPPPRSIKEIVLRQCPSSYQPHPAFFATETPRSLAAHAMSCPLDQALGLLVCIFHKYSGKEGDKNSLSKKELKELIQNELTIGPKLNDAEIVNLMNDLDQNKDQEVNFQEYVTFLGALAMIYNDALKGVL
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MTARKKSTSWQEEVARGFSRFFSRSSSQELEKEADNPSGNEQEQPDSTLSRFFSRASPPDKDKKLASEKSSLEESTEGDHQSPSRFFSRASSQDKDKKLDSEKSFLEESTEGHQSPSWFFSRISSQEKDKKLANEKSSLDESAEGHQSASRFLSRVSSQDKDKKLDSEKSSLEESGEGHQSPSWFFSRVSSQDKDKKLASEKSSLEESTEGHHQNPSRFFSRASFQDKDKKSNSEKSSLDESTEGHQSPSRFFPRPLSQDKDKNLAIEKSSLDESAGRQSPSRFFSRASSQDKDKNLASEKSSLEQSTEGHHQSPSRFFFRRTTPDKETKDKSLTPEEQEKGLNLSKLFNRGTPQDSKNVSNTEERDTFSSITRHLSVTFSQDDERDTAKSKTTKINLSSQEDKNPITVRDNNENVPVREADQNISKTEEESRMDWNHDGKSPIQEKQPKEKILEFFGQFFSFSSKSPMASPKQTPGNQDHCRESQDEPFKNNLEEEFVTVEQSFQEPDGVAQATEDKPANREIDLGTSDRKQKEENSSQELKPSPTASPVQRTSNLEAPSITYGTYRGSKKIRKLLRRRADVNSPIPEKEEVTDTETIPSMLDYSTDSEITSYTDAELCGGPDEQTANLKNSSTLPSYLERNTKSEEPLQPESYSHSNKRYAVDLQGNSETVTLLHHSVREETIISIGLQTEDHEEQEDRNQGIPNRIQSFIVDSQPDITPINGNKQILKLNGTSEDESSKQNRSTINNLQGDIEDNSGYVEAPQKETNPPVELAADEKPKTITILQNDAGDISNRTDTVQPHEVKYSKKSGVSLSLADNNSNIIELSSYSSSSTGNNILVNDVDDSTKEMKFSLHEDAKLTHEMLSTPQFPGPLESDNDNNSISSDGDFEKLQHNKSITSHFVQSQTLDSLSVEKSYKTSNPPSNKHWTHVYVQESLDNVNPSGKPDINEIPHAEEVLITADNNISDDRNKQLINVPPEAATSFNLSASFSDSDLQKVYANSLSNICSLSSSSLNEGNIREADSFDEGHSPTFAIPSSSSSFVSACVDEQRKGPLPSSDSVDSGLISSACTPDEVIIYNNYKPETLALDDQGNNKIVESDKTVHNVFNLKTVEVKNTNQVDYIPTTENVRVLSESNTIQGTNVVIVNNITPKLGNNTTTEKTVPSLKERIGKLSSNQISEPNSKDVYFAKVSVKSIDVKEVRKIAPHNLQSEIITTSKLPTPTFESEYIQLSIPPPPPIDSDLQGFQQDQEKSSFKHFNPKDDTASNVQPDIEVARVLTSTSPDVTIENIKNNNITALMRASNDNFINMSSLVGTHDNEIDKILSICVSEMETKDVNLQDAQKEPKETNIYFSLQAKVNVSHEIHGKPPALPMHSTITVEKDTFQVATENSEFYDTLLKQKANEIICTVLNKAVEEIAPNNSTTGSIISLSNENSDIEAIQLNSANVEENAVLDSFNCSPAIISNEVPSDPSLESVIPIMQETLLGTQKEHSNEAETTGKIYISNNSTLDHENYQFSINEFGLDTEKIPKELGHLDDILLSHTQNYGTNVDELLTSHEALKVDHAKVDTNELSSTSENYRTNFGEINHSAKELLIQTSDEALKVDQSKEGMNELLSILRNNIPSVDEINHSTNELLTQTSGEALKVDQVKEDTSKLLSASEKDRTNFDEIEHSTKSSNELLTQKFDEALKVDQTKENTNENQNCEQGATFVVSDIIGVKHTSCDNFQNAADSGLGGVIQEKAFADESYQVTNQMYPKSNDPFVSMANEIVCDIITSATQNVTSGMLQASLNKNIDGKIQSEIEMNSASVSLTGAGSIATQNTENSKTIISLYELEKDYNITAELTNTDGEQNQDNSTLEGTVNGFDIITKVSIPTHSPHLGWSLGTDEDFDSYECMNNTDVHSGEIVGEAVHMVATDTDFLSPLQFSIHQAHVIEISENDDDQDNNEYYVCDSEETSDQDSYFVVHARRRRIYPFSLSPIYEDDSSSEDILSTSASPKNSEADHSNCSSILTLLQSVSDRLKQTNILDNEEVSHEECSSLPDMSAHSLDGHSNMDGAEKTEDVSKTQVVDQPVFSHSQIPTRSSLFITKTMPEIKSLVGTGRQSILMHLTKKSIVLNSKRSGETLSPTAVEEGLPLQKLEDSNLNTESAAIPPLVNQSAVLVEESSKPNQKFEVEVKSHLESRNVHYQSNLNSQNNARPPEPKTVNCQENIDTSKQDDSLILINPKCSVEGSLPPTLEDSSSLQKEVNSSLLNSKSKTEVVSSPSPSTSQTASESVLPIQVPEVEPKSHHTMLKKCPSPPEIKRDDFQKLEQDHSLKTQAPLMSPEQPETIRYNPRPGKVVLSDILHPENKIEVNADVTGASSWIFPNGVNIRVIRGCWILYEKPSFEGLSHVLEEGEAELSYLWEAPQSTSEPNRIIIGSIKRVVKDYIPEIILSPQYPIIGSSIHLRTEVPSIESLSCHIHHSLVVKSGVWLAYSQPQFNGPATVLEEGSEIPEIQEYGIRSVRPLKMGGLKVQMPSDPKIILYEKPYFEGKFREFAEHIYCIKSLFSDDDEQEIGSIRVLGGIWVGYDLERFKGRQYLLEEGEYPDWQSWGGSRSSLHSMRYLQADFMETSVTLYESDREDLKQLEAFNLGIPDVEQAGYGPETQSIHVKKGMWVAYEQKHYCGEQYILEKGRYKSCADWGGNNNTIMSIRPVLLEPHGSNEPKHLIKSYSGVNFRGECVDFTKEVSDFKSFTPSSFKVLRGCWLLCYQGDTSDNLCVLEEGHFPDMVSCGCPAAVIKFIQPIDYVFAEPSLSLFSLDSCEGRELHFEEAVNSVLSRDLHFYTQSVWVRSGLWIAYEEAHFLGRQILLEAKKILNWAEFSGWNAIGSLRPLKQPAVYLRIKNRHNNKYLTVTGNLADTRAMSVCVSPRNGPSTQIWYFCRGLLKSKASDTCLDIIGGKNIPGSKVSLWTELGKLRQKWRIHKDGTIASYISEELVLDLKGGNYYDQNHIVVNNLQPGLSTQKWDIEIL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
Miscellaneous:
MISCELLANEOUS: Despite its homology to transthyretins, is not able to bind to the thyroid hormones thyroxine (T4) and triiodothyronine (T3); MISCELLANEOUS: Although some crystallographic structures were found to contain zinc, the purified protein does not contain bound metal ions, and does not require zinc or other metal ions for enzyme activity; MISCELLANEOUS: HIU hydrolysis also occurs spontaneously, but more slowly.
Subcellular Localization:
Periplasm.
Sequence:
MLKRYLVLSVATAAFSLPSLVNAAQQNILSVHILNQQTGKPAADVTVTLEKKADNGWLQLNTAKTDKDGRIKALWPEQTATTGDYRVVFKTGDYFKKQNLESFFPEIPVEFHINKVNEHYHVPLLLSQYGYSTYRGS
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cell membrane; Single-pass type I membrane protein.
Sequence:
MKKMRCCLVTTTVALLLITYVYADVLSESHHVTTRQATGSGRNNRVTDGTFSTPGQQELERSGSPRSNANKRVYVENKYRPVFYQCESATLEEGKQPGTVVSTVRAYDNDTDSAGEIFFTILRAGSEKEFEVDPVTGTIRSSKSFDRDEPAREKIAYVTVKATDRGTPPLEAICTFNVTIGDINDNAPMFDKSAYDESVPRDLELGKLVMRIAATDVDAGENAHISYGWDAGSGPDAEYFDLDKSTGAIHLKKKITQNEGYKFALMAVARDNGTEPMNSRVRVMINVASSKIKPPYFSDIPEPVSLPENYTSYKTAIATLGAHSNIAAPDLYFELVKGQTEQTNSDETFRINELGNSVNIHVAKALDYEKVTQYILTVRVKNEAGVAAETVLTVNVEDVNDEIPTFMAVDGGSVLENSPANTPVLTVQATDRDATYPNNWVRYELRDFKDKFEIDRNTGDIKTKVKLDREERKSYPLTVVAFDGKESALTLDGLPNQSAKRFQIEVADVNDNAPFFPQSEYFAEIAENADIGAKVSELTALDNDTESQLTYDIVSGNAGLVFSIEAQTGLLKVHQPLDYETTKSYDLIVEVDDGKQKATTKVNVKIINVNDNKPQFMNSNPEQIHGIVENTVPLGPIVRVNATDPDYDPSTADGPMKITYTLSGSHADSFQINQLGELSIVKPLDRDLPEGRRDWSVFVVAQDELDGVRLENTLEVVVVLDDVNDNAPFLEQTRVVWRENQPQGRIVVLSATDYDEPKNGPPFAMKMADTAEDIVRTSFRIDGSPTSSWSLMATKTFDREERKEYAVPIVISDSGQPTSLTATSTLTVVIGDENDNPMSDGSSSILVYNYRNSLPDTEIGRVYVQDADDWDLPDKTFGWSTTVTPPPYFTVTALGGYITMRARTPPGNYPLKFHVTDNIRQEEADATVIVTVQEITEEAVRRSGSIRLSGIGQEEFIKDSPSKKDLLRQKVAEYVGAKEENVDVFTVMSSSPTRNHSVDVRYSAHGSPYYDPVKLNGLTAAHQDELERILDAEVLMFGIDECLHEKNSICSEGSCTNRLQITEQPYRVATNTSTFVGVDARIVPECVCLADEYLSSSTCSATSCLNGGTCTGDSVQPCRCPDGFQGPRCEGLDVSFGGTGWAWYDPLPTCASGFLSLTVVTQTGNGLILYAGPTAVPPDTSVTDFLALELREGSPVLYLDLGSGTRRLELPDRSRNLVDGKAHDLEISWNQRSVQMRLGQCSDGQPYCSASSSLVGSNEYLNVNGPLQVGGITADLQKLRLALKWDYIPTDIGYSGCIQNLTFNGLTYNLFDPGFFKNATPSCAGVVLPVQTGAFGWEIIIIILGILLLLMIIVLVLVAYRRRSRKDKPKDFHDDIRENIINYSDEGGGEGDMTGYDLSVLRMTPDGKPLIGRSDDYGKLLKDEDLRPKRAAPGQVPDISQFLDDNKGRVDRDPDGLAYDDLRHYAYEGDGNSMGSLSSLASGTDDGDLDFECLSDFGPRFKKLADMYGDHSSESEDGEDGQQGGQSGSESWC
The following text describes a protein:
Function:
Transcriptional coregulator. Involved in control of the cell cycle and in modulating mitotic histone phosphorylation. Plays a role in modulating lifespan by regulating the transcriptional activity of daf-16/Forkhead box protein O, in concert with protein deacetylase sir-2.1/SIRT1, and perhaps acting independently of the Insulin/IGF-1-like signaling (IIS) mediated pathway. Negatively modulates responses to environmental stresses, including oxidative stress, heat stress, and exposure to heavy metals; acting via regulation of the transcription factors daf-16 and skn-1. May play a role in pharyngeal development via positive modulation of expression of sup-35.
Subcellular Localization:
Nucleus. Note=Localizes to nucleus, except for nucleolus.
Sequence:
MDEDVGLEATNYSRGDESRSEEQEKNVVRWRIVQQSTGPNPKPRHGHRAVVLKELIVIFGGGNEGMIDELHAYNTQKREWTAPQCCGDVPTPAAAFGAISLGNKIYRFGGMTEYGKYTNDLYELQSTRWEWRRLNPRVHSNGHLPCPRIGHSFVVSQKSQKAYVFGGLSNDLNDPKRNVPHYLDDLYVINLSGPQHLIWEKLNATGPGPISRESHTAVIYEKDSISRMVVYGGMNGVRLGDLWYLNLNTLHWTEIKFDDPRTGIPPMPRSLHSSVLIGDKMFVYGGWVPLLEHASTEQQTEKEWKCTSSLGCWNITEDRWVPLHLYCSDEDTIPRGRAGHCAAAVGDRMYIWSGRDGYRKAWSNQVCCRDMWLLDTILPEQPGKVQLGRAGFNSLEISWPIVQGASGYFLQIGFGDAKEQSVSPIKRATTSPRKQPSIVPPSQKETEQSPKKPQGTAPSIISTQGTTYTAPADPKPATDEGGLPQDLFEDTEKNETASPKRSNDAQSADSSTCEQKKTDESGLEEDSEKDQKPSDAGETDEMKEENGDDDLPWFDVGIIDKATINVTHYFNDRQQSLEKQLNDLIDHNAFKCVNDSVFTTEDKIPLINGQSYRFRVSAINGLGKGAWSETASCKTCVPGYPSAPSSIRITKSHEGAQLTWEPPSNTNISGKIIEYSVYLAVKNQSANSADSQLAFMRVYCGPQADCQVLQSNLGTAFVDQTNKPAIIFRIAARNEKGYGPATQVRWLQDQQKIPVRTNYPNNSGFIYQQHGGQQKRARFDHQ
The following text describes a protein:
Function:
Plays a key role in hydrogen peroxide removal.
Miscellaneous:
MISCELLANEOUS: Binds one cation per subunit; probably K(+), but might also be Ca(2+).
Subcellular Localization:
Cytoplasm.
Sequence:
MAKNYPVVSAEYQEAVEKARQKLRALIAEKSCAPLMLRLAWHSAGTFDVSSKTGGPFGTMKTPAELSHAANAGLDIAVRMLEPIKEEIPTISYADFYQLAGVVAVEVSGGPAVPFHPGREDKPAPPPEGRLPDATKGSDHLRQVFGAQMGLSDQDIVALSGGHTLGRCHKERSGFEGPWTRNPLQFDNSYFTELLSGDKEGLLQLPSDKALLSDPAFRPLVEKYAADEKAFFEDYKEAHLKLSELGFADA
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MRDFNNAQITRLKVRQNAVFEKLDLEFKDGLSAISGASGVGKSVLIASLLGAFGLKESNASNIEVELIAPFLDTEEYGIFREDEHEPLVISVIKKEKTRYFLNQTSLSKNTLKALLKGLIKRLSNDRFSQNELNDILMLSLLDGYIQNENKAFSPLLGALEEKFTRLEKLEKERRLLEDKKRFQKDLEERLNFEKMKLERLDLKEDEYERLLEQKKLLSSKEKLNDKIALALEVLENTHKITHALESVGHSAEFLKSALLEASALLEKEQAKLEECERLDIEKVLERLGMLSGIIKDYGSIMHAKERLGHVKNELHNLKEIDSHCETYHKEIERLKTECLKLCEEISGFRKEYLAGFNALLSAKAKDLLLKSPSLVLEDAPMSEKGAQKLVLNLQNSQLETLSSGEYSRLRLAFMLLEMEFLKDFKGVLVLDEMDSNLSGEESLAVSKALETLSSHSQIFAISHQVHIPALAKNHILVFKENHKSLAKTLNNEERVLEIARMIGGSENIESAISFAKEKLKAQE
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIIFDLLNNFQEVKGDFKVGKSYYWIVVHSQDLNALKDKLNLKEENIRECENYTQGAQINFYKDYVFIILNLLQYDKVVEANEINIFLSKDYIITVYKEKLSLIEEILDDIKECKNCFLIKENPKPFILLYYIIDRIIIKNYEVIGTLETEADKIEIDILKEPRHEHIDEIIYLRRQVYRIKKYITPLRYIGDSLISNDNGMIEKECVKYCMALNNKIEKLMVALETLVQDLSLVREAFESEISNKTNELMKVFTLIATIFLPASLITGIYGMNFDNLPPMKNPYGYLYVLGFTLIISLFLVYLFIRKKWL
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MQRKKSDSSDGLQELYRSLEKISLSAFGKHRPSTKQEFRRSFVKRCNDPFINQKLHHIRALKSTLKMKKLAAITAFASLNVYAITEEETPQKPLQPSQLPIYNAPSLHSKYIEEQPGRLQTGIASIRTTAWHYVGWCKGIYVWMKNGIMDTVQFGKDTYVYLKNPPQDFLPKVGVITASGLLGLISSKNGSKFKKIAYPLGLTTLGASVCYPAQAIVITKVTGEKAHATSQQIYEVLGSWWTENYTQKGAELKEETELRREIRLETPTKMAATGSSTSAFSVEVARKLEPSSAGAVTATQFKADPKLMDHGQSNPEDVDMYSTRS
The following text describes a protein:
Function:
Does not bind chitin in vitro.
Subcellular Localization:
Secreted. Endoplasmic reticulum. Cytoplasmic vesicle. Note=Localizes to the peritrophic matrix ligning the midgut and on the surface of fecal pellets.
Sequence:
MKFNIIIVFISLAILVHSSYAANDNDDDPTTTVHPTTTEQPDDKFECPSRFGYFADPKDPHKFYICSNWEAVHKDCPGNTRWNEDEETCT
The following text describes a protein:
Function:
Plays an important role in the elongation step of protein synthesis.
Sequence:
KLSQSLPKNEVTVTEYKVNAFIKAAGVNVEPFWPGLFAKALANINIHNLICNVGAGGPVPAAGATPSGGPDPVTTAAPREDKKVEAKKENSEESDDNKGFGLFHSTSVTHSVIKS
The following text describes a protein:
Function:
Could be involved in insect defense mechanisms. Inhibits insect-type alpha-amylase.
Subcellular Localization:
Secreted.
Sequence:
PTSVAVDQGSMVSNSPGEWCWPGMGYPVYPFPRCRALVKSQCAGGQVVESIQKDCCRQIAAIGDEWCICGALGSMRGSMYKELGVALADDKATVAEVFPGCRTEVMDRAVASLPAVCNQYIPNTNGTDGVCYWLSYYQPPRQMSSR
The following text describes a protein:
Function:
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
Sequence:
MKQHKYTAYYCEENIYNLVQDMMEEKQDHLTQHYAVLITNPFQQTYIKCQKSSPLVVWDYHVIMVVKHTYQQEGKITQNSFVYDFDSTLPMNCDFNTYFKQALGFQKPQATLKSWFRVVDGQKYIDYFASDRHHMIKNGKYLQPPPQYPCIKGSKQEKNNNLQDYLDTTNNDPLLGKWMTEEQFQQFFAAKKA
The following text describes a protein:
Function:
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator and promoting expression of vegfa.
Subcellular Localization:
Nucleus.
Sequence:
MTGQLRKKKLPANFQKEEIIQRWWLERGRDRKGQRWGGFIYTRRPYRFLLMDVKCVTLRDLKSPRRSCSGGPPKDAGHTEQKENVCVDRRKSIPLKSAESSMLLKSRRTLTLDLTPIKHSAPAEPWTPTANLKVLIRAASSDIRDREMKKVLFRPLENDKENPGSPDGSVEDPELEDLCQFAAMNEKEDEDKKPSRKQKSLGLLCQKFLARYPDYPPSQPLIWISLDEVATSLGVERRRIYDIVNVLESLSIVGRIAKNSYHWYGRQQLQATLQELQQRGREQGYHLQMDQAADTGRIDSSREEEAAEAETGNAGGNRKDKSLRIMSQKFVMLFLVSKTQTVTLDAAAQILIEESRDSSSHSKYKTKVRRLYDIANVLTSLNLIKKVHVREERGRKPAFRWLGPVEFSGIGNAQAPAKHPQPASQQDARKLKLCRHSSFNTAPSAAAVERQVSSAPCSPRCAPRSPNQPVDYSRKAPAELHASHLSPPSSTHQAVLAAHPYPEPLLLSSPHCLAYLPSLSRPSLLTLFRGPKTLQQTPEGQGLSSPEAGKKRRKESEEEEEMGGKRTGKSGSNDVAELGAAAESAQLHSSRTSAAVCADSSAEQPSHYLYLPNTAGLNSLNFLIPAGQPPASVAIAPGSIPAMALPYVFLPSAAIPHYPLVAGSMQHLTSDSPTPLGFGLPAMVPPGHFMVGATPFRAAVSSDVSRTALPSPGSTPTQSRFSPSQASINSPEPQTPHSPKETPCSSSKAFFRTPGTLGNMVSSRPAGRKRGSAQRRLDVGHPAAMLRVCNPGIFY
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Localization:
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVYRHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMSLQAGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore.
Sequence:
MADEMDFYSSDYHNDDAFETPSKPPTSTSGRPKGSGAQGGGGMRFDTEEAREAALRKELEGVRKINEVIEGMIGTLERAKGNMGTVSQTVTNATTLLNTWTRMLSQTEHNQRLILNPEWKGATQDLLELEAEERRRQEEVERRAAEAERRREEARRKAEEEERRRAAAAAAAAAPAGRSVGRGTTRGRVRGSGLTRGASSSASGSETTRTTSGIARGGFGYTRGTARYRGAK
The following text describes a protein:
Function:
Implicated in the a- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Miscellaneous:
MISCELLANEOUS: Present with 2050 molecules/cell in log phase SD medium.
Sequence:
MAAHQMDSITYSNNVTQQYIQPQSLQDISAVEDEIQNKIEAARQESKQLHAQINKAKHKIQDASLFQMANKVTSLTKNKINLKPNIVLKGHNNKISDFRWSRDSKRILSASQDGFMLIWDSASGLKQNAIPLDSQWVLSCAISPSSTLVASAGLNNNCTIYRVSKENRVAQNVASIFKGHTCYISDIEFTDNAHILTASGDMTCALWDIPKAKRVREYSDHLGDVLALAIPEEPNSENSSNTFASCGSDGYTYIWDSRSPSAVQSFYVNDSDINALRFFKDGMSIVAGSDNGAINMYDLRSDCSIATFSLFRGYEERTPTPTYMAANMEYNTAQSPQTLKSTSSSYLDNQGVVSLDFSASGRLMYSCYTDIGCVVWDVLKGEIVGKLEGHGGRVTGVRSSPDGLAVCTGSWDSTMKIWSPGYQ
The following text describes a protein:
Function:
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
Sequence:
MATAAPSPSSPLRPEDLLSDSSEPPGLNQVSSEVTSQLYTSLHLSRQAEATARAQLYLAPTSSPPNEGLDSLAQELSRSLSVGLENNLKKKDGSKHIFEMESVRGQLQTMLHTSRDTAYRTGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAPALEELFPRYTSLRPGPPTNPPDFQGLRDALDAELTRRKHCERHIQSLQTRVLELQQQLAVAVAADHKKDLMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEERQAAELTRSKQQETVTRLEQSLSEAMEALSREQEGARLQQREKEALEEERQALTLRLEVEQQQCRTLQEERDEARAGQLSEHRKLEALQVALQEERQAWIKQEHQLKERLQALQEEGQAQLEREKGNSQREAQAAWETQQQFALLQTEVRRLEGDLDTVRRERDALQLEMSLVQARYESQRIQMESELAVQLEQRVTERLAEAQENSLRQAASLRDHHRKQLQELSGQHQQELAAQLAQFKVEMADREERQQQVAQDYELRLAREQARVRDLKSGNQQLEEQRAELVERLQAMLQAHWEEANQLLSTTLLPPNPQAPLAEPSSPGPLEPEKGERRTWAMPPMAVALKPVLQQSREVKGDVPGAPSVLCSTSPDLSLLLGPPFQNQNSFQPLEPKPDVTPPTAGPFSALEAFTDDHRAERPFPEEDPGSDGDARLPPASQLEGLKNFLQQLLETAPQSNGNPSADLLLPKAGSRAVSSWEEAPQVPRLPPPVHKTKVPLAMASSLFRVHGLPSTNLQGSGLSTGSPEKDGLNLVDVSELLRLYQARGWGALPAEDLLLYLKRLEHSGTDGQGELVPRRNTDSRLGETTRKEIPSQAVPRRLASVPKTEKPARKKSGHPGPSMRSRGGIWR
The following text describes a protein:
Function:
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, P-body.
Sequence:
MGGGERFNIPGQHRNNLGKQIARQKLFDRNNQKMSMSHTKDRSRGCGTSLAWQAMQNGVNNNTLSSNQNWSAGFPASNNLFTNQDNQNYAGAKFSEPPSPSVLPKPPSHWVLLSCSPAEKELMSFQLKTLLKVQA
The following text describes a protein:
Function:
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase map1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of map1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of zng1 to the zinc binding site in the peptidase domain of map1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active map1.
Sequence:
MDFEIENESEIPQLVDVEEVNTQPHSETLSVPTVSSNNDIDSFEQQSDFLLVDHDSTLDPVPVTILTGFLGAGKTSLLRSILENRNGKRVAVLMNEVGDSGDLERSLMEDVGGEELYEEWVALSNGCMCCTVKDNGIKALEKIMRQKGRFDNIVIETTGIANPGPLAQTFWLDDALKSDVKLDGIVTVIDCKNIDNILKDESDIGFIQISHADCLILNKTDLISSEALSVVRQTILKINCLAKIIETTYGRLDDISEILDLDAYGNENTSNLEWSIQRSNDSNINCSTCLDVDCQHLHSLDTHSLDISTHTFKLPPLMSKEVFQQFLQWVRHTLWSCLEEGEDEEFMIYRSKGIFNKDDGSWYIFQGVREVFEIMPLSEKPRAFLEKDIHPEIILIGRNLHRISPFVVGNQ
The following text describes a protein:
Function:
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLTGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSVQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK
The following text describes a protein:
Function:
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNTSSSTTLTMNDTIAAIATPLGKGAISIIKISGHNALNILKQLTQKQDFTPRYAYVHDIFSNGVLLDKALVIYFKAPYSFTGEDVCEIQCHGSPLLAQNILQACLNLGARLAKAGEFSKKAFLNHKMDLSEIEASVQLILCEDESVLNALARQLKGELKIFIEEARGNLLKLLASSEVLIDYSEEDIPSDFLDGVSLNLEKQIASFKDLLDFSNAQKQRNKGHALSIVGKPNAGKSSLLNAMLLEERALVSDIKGTTRDTIEEVIELKGHKVRLIDTAGIRESADKIERLGIEKSLKSLENCDIILGVFDLSKPLEKEDFNLIDTLNRAKKPCIVVLNKNDLAPKLELEILKSYLKIPYTLLETNTLNSKACLKDLSQKISAFFPKLDTQNKLLLTSLAQKIALENAITELQNAKNHLETLELFSYHILSAIENLNLLTRPYETSQMLDSMFSEFCLGK
The following text describes a protein:
Function:
Quorum-sensing regulator that controls the expression of multiple virulence factors in response to extracellular signaling molecules called autoinducers. Involved, among others, in the transcriptional regulation of genes that are responsible for rhamnolipid surfactant biosynthesis. Acts by binding to a specific sequence in the rhlAB regulatory region, both in the presence and in the absence of its autoinducer. In the former case it activates transcription of the promoter, whereas in the latter it acts as a transcriptional repressor. Also regulates the expression of the rmlBDAC operon, encoding dTDP-L-rhamnose biosynthetic enzymes, by binding to the rml box in the promoter region. In addition, is involved in the regulation of the production of elastase (lasB) and pyocyanine.
Subcellular Localization:
Cytoplasm.
Sequence:
MRNDGGFLLWWDGLRSEMQPIHDSQGVFAVLEKEVRRLGFDYYAYGVRHTIPFTRPKTEVHGTYPKAWLERYQMQNYGAVDPAILNGLRSSEMVVWSDSLFDQSRMLWNEARDWGLCVGATLPIRAPNNLLSVLSVARDQQNISSFEREEIRLRLRCMIELLTQKLTDLEHPMLMSNPVCLSHREREILQWTADGKSSGEIAIILSISESTVNFHHKNIQKKFDAPNKTLAAAYAAALGLI