lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF3 binds DNA constitutively only when the C-terminal region is deleted.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
Sequence:
MREGSALPGAPGAAPVPGFLAKLWALVEDPQSDDVICWSRNGENFCILDEQRFAKELLPKYFKHNNISSFIRQLNMYGFRKVVALENGMITAEKNSVIEFQHPFFKQGNAHLLENIKRKVSAVRTEDLKVCAEDLHKVLSEVQEMREQQNNMDIRLANMKRENKALWKEVAVLRQKHSQQQKLLSKILQFILSLMRGNYIVGVKRKRSLTDAAGASPSKYSRQYVRIPVESGQAMAFSEHNSDDEDGNRTGLIIRDITDTLENATNGLLAVAHTSGRDRETQTALDPGLPICQVSQPNELSCAEPIPPVHINDVSKPNEMGNVAVELHTAQANAPEDPVSVIDSILNENNSGNQNDPLLDREEIQDFLNCIDASLEELQAMLSGKQYSFGSEAFSDVFNPELPALDMNLMETSPGMENIANMEDSTEDLGASERETAGSKGGQEGTESCDSSVLFQNCVLKWNFSSL
The following text describes a protein:
Function:
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MKAKAILLASVLLVGCQTSQNTGNVQQHAQSLSAAGQGEAGKFTSQARWMDDGTSIAPDQDLWAFIGDELKMGIPENSRIREQKQKYLRNKSYLHDVTLRAEPYMYWIAGQVKKRNMPMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRNYDARRDVVASTTAALDMMQRLNKMFDGDWLLTVAAYNSGEGRVMRAIKANKARGKPTDFWSLSLPRETKLYVPKMLALSEILKNSKRYGVRLPTTDESRALARVRLNSPVEMAQVADMAGMSISKLKTFNAGVKGSTLGVSGPQYVMVPKKHAEQLRESLASGEIDAVQSQLIADNTPLNSRSYKVRSGDTLSGIASRLGVSTKDLQQWNNLRGSRLKIGQSLTVGAGSSAQRLANNSDSITYRVRKGDSLSSIARRHGVNIKDVMRWNHDTDNLQPGDQLTLFVKDNSTPDS
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MIELRHVSHHYDERPVLRPLSLTLRERRIGVVGSNGSGKSTFARLLNALLLPAAGQVLVDGLDTRQDPKGVRRKVGFVFQNPDHQIVFPVVEEDLAFGLKNLKLPPAEVEARIGEVLERYDLGEYRQHPSHLLSGGQKQLLAISGVLVMRPEYVVFDEPTTLLDLRNRNRVAAAIRELPQTAIVVTHDLDLLRDFERVLVFEAGELIADAPPAEALRVYRERMTWP
The following text describes a protein:
Function:
Probable polyketide synthase.
Sequence:
MDNYNLDNNSEDVAIIGVGFRLPGDSNTPDQFWENLKNKFNGIVDATQEYQRWSENHVYTGEIKSKNAGLVSIDEWKSFDPLLFGIAPNELGITDPQQRLLLKSTFEALEDAGLDPIQGMRGTNTSVYIGATTIDYKMTAYTEKDNSINSLISNLHTMSNRISYCFDFRGQSLTLDTACSSSSNAIHLGYKSIVNGDSEYSIVGGSNLIIDTLYTKAVSYLNMAGAGGYCKTFDSAADGFVRAEGCGVLVLKKLSNAIKDGNNIYCVIKGANSNADGTFNKTTFFAPSKYAQNANLEKVLLDSKTNPSDIDYFECHGTGTPTGDPIETEAISMSLKDHRSNNSPLLIGSVKSNIGHLEPASGVASIIKCCLMFKHRQFAPNIHFNNPNPNIKFNEWNIKVVTDLTPFPKNKLVTIGVNNFGATGSNVCIILKEYNQQLQLQTSQKSKNEINYLIPFSANSKTSLEDYKSKILNNISNYSNKIEFNDFIKHQVFCKSPNFLQRSVISAKDWNSFNDNFKNQIKTSSNKSYNILHKHSNPEIIFVMCGQGPQYTSMALKLYENNTIFRKSMDMINEKLSKHAGFNILEKLRSIDPTDKKSINDPLIAQTSLFIVQFSLIELYKHWGIKPSIIVGHSFGELASTFCSGMINLEEACFLAYQRARIQSLTVTNNQDKSLNSRMLVINISEEQFNQKYSSRYPDITICCYNSPSSIVVGGNEAKLIEIHNESKSNGIFSAFLGAQTAFHSSAQESIKDLVYSLKQIKYNKPTIPTFSTVTGELFGNNEIEPPASHYIYSNIREPVMFSKAIENIFNHIETQNKNNRAIFLEISPHPTLSYYIKQMIPKESNYFSEDSITVISSLNKNKDDTQEIQNTISQLYCKGYNVNFKSQFINEDIYLPSVISNTSILPRYQWDNNQYWSESDRSLKARTEGPSIDQKGFSINSNQTIYESFIDINRPPFEYLKGHVVKDKYYFPGCGYIDSLVSIFNSKDFIIPYLEFKTPLILKEKEVKHLQTSITKTSRNEYKVSFSFKDKNEWVETSLGKIHVFNFETPIEKLNFEKLKLKCGNTKLSKDELYTHIKSKTGLSYLNHFKRVEECYQGDGCTFSKISLNPSITSFKKSFLDPSIIDTTLHGFLSYIEDPCQIVLDRVEDYRIYSTNIPSDISNHTHIYCYSEFLGKFGESLTSSLKIMLDDGTVIIEADKVVCTSLIPIRDPLQIQNPNNELFSMYWQERDSLVQKSTLNNLSFNNPDYDNNILTIIENSIIPIKNEKAIFRILQISNNYELSTNIINLINTTLSNNSEIDIEFSIGLESNQEIKDIKSQLPSFNGSLLLKEINLNQALIEKQQLKCNYYDIIILPKQLQTTSKLIKDTEIFNILNPKGYLIHNSNQSDEELNEIGFEFNNFINPITISQKPSVLSNNNSIPIYDNIFIFGENSSNESNKFIETIQNSYSKSNISKSQNSKRLKMSYKDKRIFLIPNIDEFNLHSSKITDNSVIYFITTINQIKNQNDIARVTLDYVNINQHLLKNKLSTKHIIVSTYCQKEALNYTCSAVIGARRYFEEFIDLRLFSIDFDNESLLSNNVIENIECLTSTYQHSEYLIRKNIPYFERIKKESNLKAKFKSTSYQENNGLLAKLDPNLQYKLAPKKVLNPDYVEVKTEAFCINFKDNLIYRGLVPAELINSKGDISDPEFGFEFSGIITRIGDNVTEYKIGDQVFGYSTCAASTHIYPHKNNIFTKPNNISFVEASSIPVVYMTSLYCLFNIGNLNIEEKETVLIHTGTGGVGLSALNILKWKGFKSHLFVTVGSKEKEDYLREHYGSLITGIYSTRNINYVKEIKQKLKQLGSQKDGVDLILNTFSNEFMDANFKCLCKGGRVVDVSVTHLNPHEYTDYNKFKYNIGYHAVEMSRLNSEPIRILLKQLSYGFSTQGLELLPIKEFSVNNVKEAIEFINERKLIGKISVKMDSDVLTPLLENNNQDYNCLKPDYKINHESLGKTVLVSGQTGLILEILKWISKFSTSVETIIILSKSKKRWEIEKLVSGSKNNIKYIFKSCDIGEYESIKKSIQEIYFENKHIGQVESIFHFAFQYVNHEPLEVSKNDLYASLSAKSFGAMNLHNLSLEKQWELKQFILASSVTAIFGSPIQVGYTSSNYFLDALARHRRSLGLPAISTFWGLFETAGFISKQRSIARFIENMGFTPITVNLLLGSLDLFIQNQEISNSLSVNIFNDSIDSYANKPANSKIDFISNAIQSKNKQLSGEDSGATQIVIDKISELLTIEASKINHDCRLIDLGSDSMVIISLKNFIDSNYTQNLFTISQLQTLTIGVIIQNILKSLNGNNNNNKNKKTNNVKPNNQKIISNNNNREFWEKEIKLNNTVKNLANTSIDFNKLLANDLNVLLTGTSGYLGVYLLSNLLKRSNCSKIYCLVRNKKSNNEALETIINNLKYHGLYEQITANEFKKIEIILGDISIQQFGLQDEQYNNIASNINLIINCGAYTNLISPYSECKPINVASTYEMLKFASHNEKLIKPIIHISSFSIFTNIQKEEFEDSFIPSVDQIEQCENGYGQSKIVSEYLVREASNRGIPSIILRLPFIFANPSTGIGNKNDLIQLFIHACYKLKIYPDQFKVLTNLAPITWISDNVCKMILNANCWENNSSKTYNLISDTFKIGDVLEQLSKEFNLQKLDYNDWKSRLIESKNESCSKILFLEPQRKYFTPNLKATSSTIKLLESMNSNYNDSFVTINMIKNHLNFYFK
The following text describes a protein:
Function:
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MAASAWARTAVVLLCVSDLLLLVLLPPRAFAAEGPAKTPSEATPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSQIDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVSQDRCADVTLEGQVYPGKGGGSKEKNKTKQEKGKKKKEGDSKSRASKDDNRAGSQRQEL
The following text describes a protein:
Function:
Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor tsr/cofilin, thereby stabilizing the actin cytoskeleton. Modulation of actin cytoskeleton dynamics may be essential for imaginal disk morphogenesis and axon guidance.
Subcellular Localization:
Cytoplasm. Cleavage furrow. Midbody. Note=Localizes to the cleavage furrow and the midbody at cytokinesis.
Sequence:
MHHQQRLRANGGRGGTGLGAGSGPVSGGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCREDYYGRFGDACQQCMAVITGPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRSCQPADAKARITTAGKPMHSIRLVEIPKDATPGLRVDGVALDDGCPTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKPQDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIFGRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATPAPKRSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGKTLKPLPSRTGSQGIPASNCVSPTRSSRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQQSSKTTRLNILSPEKVHRLGARLTDQKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRTIGSSGTPNSAVGERRRRAAPSPPVRTHFNTRC
The following text describes a protein:
Function:
Acts as a component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
Miscellaneous:
MISCELLANEOUS: Present with 5840 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTASVSNTQNKLNELLDAIRQEFLQVSQEANTYRLQNQKDYDFKMNQQLAEMQQIRNTVYELELTHRKMKDAYEEEIKHLKLGLEQRDHQIASLTVQQQRQQQQQQQVQQHLQQQQQQLAAASASVPVAQQPPATTSATATPAANTTTGSPSAFPVQASRPNLVGSQLPTTTLPVVSSNAQQQLPQQQLQQQQLQQQQPPPQVSVAPLSNTAINGSPTSKETTTLPSVKAPESTLKETEPENNNTSKINDTGSATTATTTTATETEIKPKEEDATPASLHQDHYLVPYNQRANHSKPIPPFLLDLDSQSVPDALKKQTNDYYILYNPALPREIDVELHKSLDHTSVVCCVKFSNDGEYLATGCNKTTQVYRVSDGSLVARLSDDSAANNHRNSITENNTTTSTDNNTMTTTTTTTITTTAMTSAAELAKDVENLNTSSSPSSDLYIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGKYIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKKSGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWKYKKIAPN
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Sequence:
MKLNKNSIDPKLILELRKNLLSWFHKNKRELPFRINKNAYRIWVSEIMLQQTRVTAMLPIYETFLKRFPDPNSLSEASEEEVMKYWKGLGYYSRAKNLKKGARLLVEKYQSRFPENYEEALLIPGVGSYTASAVLSIAYGKPHAVLDGNVKRVLSRLFLVESDPSLTSTNQTLADLAKEFLTPQSPGDHNEAVMELGALVCVPIPNCSACPLQNHCEARSVGKEKEIPASKSVENWIDLDLNFLFLKSEDKVLLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWIEELFEDSRIVPNFLQTKHSITNHRIRLKFCDLDEKNISKVEKNLKKNKHIEFKWVPESELKEEFPSSISGKLIKLRNKNKKQPELPVGKL
The following text describes a protein:
Function:
Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MISRYTRKAVPQSLELKGITKHALNHHPPPEKLEEISPTSDSHEKDTSSQSKSDITRESSFTSADTGNSLSAFPSYTGAGISTEGSSDFSWGYGELDQNATEKVQTMFTAIDELLYEQKLSVHTKSLQEECQQWTASFPHLRILGRQIITPSEGYRLYPRSPSAVSASYETTLSQERDSTIFGIRGKKLHFSSSYAHKASSIAKSSSFCSMERDEEDSIIVSEGIIEEYLAFDHIDIEEGFHGKKSEAATEKQKLGYPPIAPFYCMKEDVLAYVFDSVWCKVVSCMEQLTRSHWEGFASDDESNVAVTRPDSESSCVLSELHPLVLPRVPQSKVLYITSNPMSLCQASRHQPNVNDLLVHGMPLQPRNLSLMDKLLDLDDKLLMRPGSSTILSTRNWPNRAVEFSTSSLSYTVQSTRRRNPPPRTLHPISTSHSCAETPRSVEEILRGARVPVAPDSLSSPSPTPLSRNNLLPPIGTAEVEHVSTVGPQRQMKPHGDSSRAQSAVVDEPNYQQPQERLLLPDFFPRPNTTQSFLLDTQYRRSCAVEYPHQARPGRGSAGPQLHGSTKSQSGGRPVSRTRQGP
The following text describes a protein:
Function:
May be a desaturase involved in mycobacterial fatty acid biosynthesis.
Miscellaneous:
MISCELLANEOUS: Is a major B-cell antigen; MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell surface.
Sequence:
MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEFRRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
The following text describes a protein:
Function:
Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNFDASNDRPLKKRRFFVDDPLDTAVTPAEKSPALDASSSASTHTDPNYSANGSPAQIQTQQEYNFSNGGHATQPATAAGTRTHQAQSPAHDTLSDFDTEAFVSIVGEQVSPETLSQIRKLSDGSLEKAINVYFDGSWKNAGSPGSSQTTLLSCERNASRPSPLHTSREQGTGPAENGADSVTEPISRSKLQPARRYLGAFGVEAWATRSGIGLIKHGDTVNIERARSQPLSTRGRTGKLRVNQKGDVLTRFTNTAGQEIGRLPRETAEWVSTLLDQKICEFRGVCVFAPDRLRVNDTIYLQLRCFMRIEAFQPKELPQKQDDNRATTIFEQEESAEEKQLRLRQVALVQLFDEIGLKSTTQDDEIKKQRKEGLLRAAEMADQEAKKLAKSGNTDSGDEEPAELEQDQLDALYKKAQSFDFSMPEAQPPSSFAMDLRKYQKQALYWMLSKEKDKKSGREVSIHPLWEEYDWPLKDVDDKDLPIIEGINHFYVNPYSGELSLDFPAQEQHCLGGILADEMGLGKTIEMLSLVHSHRNLPPTQSLGNLTRLPVSGVVPAPYTTLVVAPMSLLAQWEGEALKASRNGSMKVLMYYGNEKNVNLREMCSAGNAAAPNMILTSYGVVMSEHRTHQALAPGTSWTPGNLFSVDFFRVILDEAHIIKNRRSKTARACYDLKATHRWVLTGTPIVNRLEDLFSLVRFLRVEPWNNFSFWKTFITAPFESKEVVRAISVVQTVLEPLVLRRTKSMKTPEGEPLVPLPKRTIRIEKVELIEQEREIYNHIYTRAKQTFNSNVAAGTLLKSYSTIFAQLLRLRQTCCHPILTRNKAIVADEEDAAAAADQDSDLKDDMDLQELINRFTATTSDAESSNEPPDPSMKFTAHALRQIQTESAGECPICSEEPMIDPAVTACWHSACKGCLKDYIQHQRDKGVQPRCFSCRADLNPQDIFEVVRYQSPNTTPTEQTPSSIGGDNVYSSSQPPPPPRISLRRINPLSPSAHTSAKIHALLAHLVRVPAGTKSVVFSQFTSFLDLIGPQLTKAGISFVRLDGTMAQKARAEVLAQFTKFETFTQEELDQAESTSAPSGLTPTPKTPKQSSSPSSPTVLLISLKAGGVGLNLTAASNVFMMDPWWSFAIEAQAIDRVHRMGQLRDVNVVRFIVKDSIEERMLRVQERKMGIAGSLGLMGEGNEEERRKERIEELRLLFE
The following text describes a protein:
Function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Subcellular Localization:
Secreted.
Sequence:
MARLLQASCLLSLLLAGFVPQSRGQEKSKMDCHGGMSSTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGTPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK
The following text describes a protein:
Function:
Potent anticoagulant inhibiting the amidolytic activity of factor Xa (F10) (Ki=4nM) and reducing its ability to activate prothrombin (F2) in the prothrombinase complex (EC(50)=40nM).
Subcellular Localization:
Secreted.
Sequence:
FDVPEPFKWVDHFFYEKLDEQHKGLFFAFFDWGKGPDYWGKDTISLSQEQVDAKFELDLEYGIFYGNGETIENPSENGDLQGIFFSWGSE
The following text describes a protein:
Function:
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism.
Subcellular Localization:
Cell membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Zymogen granule membrane; Single-pass type IV membrane protein.
Sequence:
MEEASGGGGDDRVRNLRSEVEGVKNIMTQNVERILARGENLDHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVIICVIVFIIILFIVLFATNVIP
The following text describes a protein:
Function:
Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Involved in the response to environmental stress such as heavy metals. By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury.
Sequence:
MEQASVPSYVNIPPIAKTRSTSHLAPTPEHHRSVSYEDTTTASTSTDSVPEVRIRSESSQVSRESPPIRASKAFVASYEYEAQKDDELNLPLGAIITLVTVETNEDGWYRGELNGKVGLFPSNYAREVTYKDNLVEFKQDEIMLPVAVRTLSDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKREANLVNGLSHNNIVRLLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFSTAGTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAISFKQYAKEFKDTHLQRAPSKMAVKELYSECFADKTKEEFEKRFHDLYAGSGDINRKNRHSIAPETKARRLKHHKPKKADITGPTEVKHILSVQKDDKNFRVKTYDQSSTGGTLPRLNERQSTLSLSSPDLFHISNLISGSNTVGHSAHRISRKNAIRHKKNQHRMFESPVVSPTMDDSNTFSTIDNADEVDPNHSKESKKGGTLSRAWAKLPWNKRDSKEDHDERAVAGSISSRSSSTTSSNRLITGQTTRGASAAGLLEIGARSRAQSTADGWEDPNTTKKHKVSPSDKRPVKTTNQTERYVKDLEKDTPLRPAQLPPTHRKSALDQTIPASPNSPDSINNFHPMPLSSRRTTANSSSDGAPCYDALVSHSYGAGHGHKNHFGLSDTIPLFPEEPTHYDMGPGRPFGTNGRAIVNQGGDYYGNISGQNYEGFGHGRSINQSTQYYPVGGGCDDYIPIVQKTVIKPTVGEVGNSPYSENIRCATRNVQNPQYIQCKKNQNPRRIPALPMKIQSESNLVTSGMVFTPRDEQLNGIGNSLSSLSLNEPPDIPAPLPPVVTYPIPASLISPSNRVSMSPPTRMAPVLPLGAMSSPRIMDKEILKNSSVEGTEIY
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells.
Subcellular Localization:
Nucleus.
Sequence:
MPEHPRHCDFQRGNVEIGLGPGGDLLGKRLSCPCITSHCSSEKKARSKDPQATSLLPELESTMAPEDHYHQLMSALSEASSFEETQRLYHLGIPSHDLLRVRQEVATATLRGPSGLEVHLPSSTADHRRKQGLVQRREGAVPAAATSFSEREMSQPPPLLSPQNAAHITMSSHLRPPFLGMPTAVCQTPGFSFLPSAQAEMLARQQELLRKQSLARLEMSELLRQKELGSVHRPLLPAPEVALHIPEGPDELQRRGSMLVLKHSSAPLLALPPQGPPGPGPPIPPKESARSRSEKGSLGVQPSQPKETTGAGLWAQEVSEEPSKDSDGEDPETAAAREGTSTPSQVPAGGTRAEGRGLLSGSTLPPPLPLGFPCGAVSPYFHTGTMGGLFTDEETTTLEDVNKWTVDDVCNFVGGLSGCGEYARVFGEQGIDGETLPLLTEEHLLNTMGLKLGPALKIRAQVAKRLGRVFYMASFPVALPLQPPSLQAPELSPGHQPLSPATTTSPYEGTHLPTGQASPKQENGSGTIALLSGAPDPSQLLQ
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MAVLHSKRPRMPANSQGIHQQTCINDDAAEKAKRRKSAHFHTVPDHTSISNENENPKNQAGKRVISGLAIQQQGLIQKRGKRLSAVEPNMPEVRIEVKENKYEEWMKLATDNKITANNTWSFALIDYFADLTLLRNGPDDQSINFQKASCTLDGCVKIWTSRVDSVATETGKLLSGLAGGSAETGEDDGSEGEEDEAGEPKTTRKTVRSEATLAKSFAQLQIKKFDLEFTVDPLFKKTSADFDEGGAMGLLMNHLSVDNKLREVFDAGDAVADEQDLDEEKEEGGGGMIDEVVQLEKLRNYIPITKFLADYSINPSLASFHFSSDSSTGNDNDPAIILGLKDSFPVDEYDHYDIPMATADDYNPMDPASNRRSGEGYDFFGSEDYDAVPAYGDGGFDEDGASMMGDPEDGLSAPFHNPANSNGGSLALLGPGSSHLGPFDPHRQGQGHEIVLTLGEGGDIGSGGMFEYFDKGFGKSWAGAEHWRLRKVSRKDMATAGTITTTNSKTKVDKTPFAIDFHTPMVTSLTSSTQALFTPASNKSSITLPSTFAPIRTKNGKAVSGQRQLREERLLPDDMHFSSHQLLRLFLKPQFSLKMRPGGRNMGGMGGMIGADGEIDENFWAAAAKEREGGECAGDEFGSAPAPFESQFFQDDDDYGDMDNDVDFGPIQPNVPVLCGPGEEEDDLWAGTQMELKKARPENVNFTKKAKRVDVKRLKDDIWTGLKDLVPYSDKAGDTDTDDEDSTPSTPPEPSDSEPVKTFSSIIQSLRSTYPPQKMSEISTSFCFICLLHLANEEGLRIESARGDGKEGEDVGCVGIAPVGEDGEVVLGEGLNALLGMLGAGRGGSEGMESTSEGVKKDRVIGELEALKVYKDHAAGRAA
The following text describes a protein:
Function:
Plays an essential role in chemotaxis signal transduction system in order to colonize the host stomach.
Sequence:
MSNQLKDLFERQKEASAGSKQEDNEEVLQFIGFIIGDEEYAIPILNILEIVKPIGYTRVPETPNYVLGVFNLRGNVFPLISLRLKFGLKAEKQNKDTRYLVVRHNDQIAGFFIDRLTEAIRIKQTDIDPVPETLSDNNNLTYGIGKQNDRLVTILRVEEILKKDF
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGIQGLLPLVQPAMRKVHMRAFEGKRVAIDAFSWLHRGAYACAMDLALRKQTDMHVRFCMKRIALLKQCNITPIMVFDGQPLPSKRNENQRRTAQRLEGRKRGLALLREGKRAEARRQFSQSIHIDGAIAFQLIEACRKAAIEVLVAPYEADAQMAFLAHSGYVDAVLTEDSDLIVYQVPCIIYKLEESGEAQLMEVNLLYRGAQLDSNINFASWTPTMFRWMCILAGCDYLPSAARMGIKSAYRIVRTSRSIAQICKTMSAQGFAGDAEYMRGFVKAENTFLHQVVFDPQTQQLRYLTAWPEGSDGSQHNYVGELFENELARAIACGALDPMTHRPHQSHAERSAATASAKRSANQAHHNDRSQLADADAGAGNGSTAGLHPSAAAVAALPVPQVADKASARDYLRQFEHGTAQSRTLDAFVVTRSSRAVIASSAPRAGSPVPRSSGHAPSGLSSTPPTSPTKRRTLPALRKAVSQDGQTKTSADASAYLHLQASASVTRGFKQPQSALLRTKQESTSVPSLPARPVKR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MQGAGDEGGNRGSPSTMEEALGIAKKARLEELPNGHVKQEEIGVHHAVGGDDGGAIVPAEAGHGSRVELAVKIDMSVLHCPLCTLPFKPPVFQCNKGGHLACGGCVALLPGGQCRACEDGGRFFHPCPALDAVVSSTKVECTNAGCQTYVPYHEAADHRSACPHAPCACTEPGCGFVGAPQALAGHLADLHSVPVRTVQYGRVSQVPVSGPRQLLVGEEDGRAFLLTVGALGAAAAAVSVVCVRASAATQPRFSCKMWVSLPQPASGGRSDMVLVDIQVRSSATPGAVVAVNEPTFLALPRMYMVPVAGDAASMEVPLNIRIDKISR
The following text describes a protein:
Function:
Terpene synthase; part of the gene cluster that mediates the biosynthesis of the trisnorsesquiterpene discodiene which has a function during later stages of multicellular development, during the transition from fingers to Mexican hats. The terpene synthase tps8 converts its substrate farnesyl diphosphate (FDP) into the bicyclic sesquiterpene alcohol discoidol. The cytochrome P450 monooxygenase cyp521A1 then catalyzes the oxidative degradation of discoidol to form the trisnorsesquiterpene discodiene.
Domain:
Contains several highly conserved motifs that are important for catalytic activity including the aspartate-rich 'DDxx(x)D/E' motif and the 'NDxxSxxxD/E' motif, both of which are involved in complexing metal ions to coordinate the binding of the isoprenyl diphosphate substrate in the active site.
Sequence:
MDYDIKFTWDKNQFLDQEIRIPKYTLPWDFKSSPFDKDFENQEMEYVKQFFQNYENAVNYVKKNEIGKIAALNFPLGEKDEYMVNSKLLDFLFILDDYIYESRNYEEDYVDNLMDRSSKSHDPFGREIWRLFDEYYRVGVKESVDLLIRDFEYWSRSAIKTNKYKSLNSSLSIEDYFNSRHGDFGMTITASSCTSTLYVENEIRESKNFKKFFKYFELCNLMINDCGSFKMEINEILLTNFVKVRAIQLGSIDLALKYCVGLLNKYIIKVDKYSTKLEQQYPNHSHLKKYIYTLKTFTAGHNKGYGHANRYN