lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in T-cell signaling pathway.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDFTNSSCGGSEHRQIEENKPLLGEMSATGGSKMGAVPCRRSLLHFSGMRYKLLQEGDIQVCAIRHPRTFLSKILTSKFLRRWEPHHLTLADNSLTSATPTGYMENSISYSAIEDVQLLSWENAPKYCLQLTIPGGTVLLQAANSYLRDQWFHSLQWKKKIYKYKKVLSNPNRWEVVLKEIRTLVDMALSSPLQDDSIHQAPLEIISKLLSENINLTTQEHESIIVAIAPLLENNHPPPDLCEFFCKHCRERPRSMVVIEVFTPVVQRILKHNMDFGKCPRLRLFTQEYILALNELNAGMEVVKKFIYSMHGPTANCPHPRVLPNVVAVCLAAIYSCYEEFINSRDNSPSLKEIRNGCQQQCDRKPNIPLRLLHTNPDLVSQEVTSTESRHKSVVVTSNEILVEVERNNTVNQKLKANTGNDSEPNLIDCLLICPACSTISIELSPQADRVLACYVEILKMLSDYDDWRPALAILLQPIPFPKEALAHETFTKELKHVIQRFAEDPRQEVHSCLLSVRAGKDGWFQLYSPGGVACDDDGELFASMVHILMGSCYKTKKFLLSLAENKLGPCMLLALRGNQTMVEILCLMLEYNIIENNDTQLQIISTLESTDVGKRMYEQLCDRQRELKELQRKGGPTRLTLPSKSTDADLARLLSSGSFGNLENLSLAFTNVTSACAEQLIKLPSLKQLNLWSTQFGDAGLRVLSEHLTTLQVLNLCETPVSDAGLLALSSMKSLCNLNMNSTKLSADTYEDLKAKLPNLKEVDVRYTEAW
The following text describes a protein:
Function:
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma, T-tubule. Cell membrane, sarcolemma; Single-pass type I membrane protein. Membrane, caveola.
Sequence:
MPSAVKGCVHFLFWTQLWRPRQRGSAWKPFFSHSRLQTRPTREGLAWGAAREELPWTPHTHAQPGGRCPRGKAQHDSSWAAQPKARRSKTRSRVDRFFLAPEKRPSRRSSRRTEMDLWILLPLCGILIGSTVAEPPPPKDVPHDPFHYDYKSLRIGGLVFAVVLFLLGILIILSRRCRCKFNQQQRTGEPDEEEGTLRSSIRRLSTRMR
The following text describes a protein:
Function:
Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.
Subcellular Localization:
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Sequence:
MLIHMCTELHADAHTRNPFILSHSQCQAARRESPACSPTSLPGTAWLSPLPCLPLSHPHPKLLHEKVGLGLVAMGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF
The following text describes a protein:
Function:
Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MKSFTVIALAAVALLATLGQAKHLDSKVADKDFLMKQKFMYQILQHIYQDDVFTTPFGGSYVEYKPWEHVADYVHPEMLEHFFELWQHQPFTDDMVWSVMYDKHEEYVVGLVRLFYFAKNWETFQHVVYWARQHVNKQLFVYAVTIASLFRDDMQGVVLPAHYEIHPWSYFDSQALEWAEHYKMHGFHHVKQMDNIYNVVIRTNYSNVHGSLNYDHDLAYYLEDVGFNAFYYYFNLDYPFWTKGGEEHVLNKDRRGELYLYVHWQLLARWYLERLSHDLGEVPAFNMYVPTESGYASNLRTYYGVPQWHRENHHSFYHEHNYEHIEHVEMYTQRVMDWIHKNEKFDVETINVLGNIIQGNADSVDKKFYGSLDKLYRFIVNEGHHYGHGDESFPGLFMHYDTSMRDPIFYEVYKTIVSHYWHLMETYPEYHKKDYAFEGVHIDAVHMPESLTTYFEHFDSDISNAVNVEPAVEGSADPLYTFGRNSHYKGSSYVIKARQQRLNHKPFEFTLDVTSDKAQDAVVKVFIGPKYDEHGHEIPLEHNYQNFFELEHFKVHLEAGVNHIKRASGDFSFWVNDRTTYLELYQKLMDATNSDYKFKLDQSEAHCGVPNRMMLPRGKKGGQVFQFFYMVYPYHQPEVAQFTGYDPVVSCGVGHGSRYVDALPFGFPFNRPVKHDYYFDVHNFKFVDVKIFHRDEHTNVV
The following text describes a protein:
Function:
D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr).
Sequence:
MDIKLVYSTLDPVGVTIKKLGYRFEEINEDVTDFHYENGEAIVIFSRHESKAGIPSLTVHYPGNPSEEIMGGEPKKLGIAYPRLLTSILREIKKIDLNIEKTMEATHHGPTYQNVPVIFVEVGSNETYWTNDTIVKALVDSTIRSIDKVDEIDCEYYISGFGGPHYSRLFTKLADESCIGHVISKHYIDKLDDKVIIQTITNSVNTINKVVIDSLNSKQKERIIASLKKLNNINIEFR
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.
Subcellular Localization:
Cell membrane. Note=The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells. Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1.
Sequence:
MSNTNINVQSSTPKKSLGSSQYSLAGSSSSNLNNINNNNNNNNNNNNNSTGQENSIDDSGSSSFVNFPASEWLSKAMHKHPDILELRERTRPITQVKSYSRNKRSSKTEASHSINDTMLLKLIMQYFHEENLTTSLKKIQEETKVQFTPNEVDKDSLENLLRIGIKDTNWFGPLEDIEDADPEVETYHSYISEDSLNENGLEGEGNLIEDRYDESQISRNPDGTIKAATFNRLLLWLIGNFNGPDVNEFKKIFFLTYPSFTTAEAILNKFTQIYQLFDNIESAQVICFIRFWIEQHPTDFNEKLLAILNNFIEHQVAASHAKQLRAVINLKIENYKEARKEIKDPPEPKVPKNIFSPTLTFDDIDEEEIARQLCCIDFALYELIKPSEFLIKGWTKPQYRNKAVNLLNMMRRFNDFTKWIAASILNEQNSKGRSKLLGRFLKISEHLRANNNFHSLMAIYGGINNTHVFRTKAIRKDLSRQQQETYAELEKLFASENSFRNYRIAYKDAKPPCIPFLGIHLRDLAFVDESNPDRINNLLNLNKRRVIWRVIVNTMRYQPIPYYFLKVHQISLFLTELKTESEQPQLTLDLSSHDTVLPSSPSSK
The following text describes a protein:
Function:
Member of a two-component regulatory system ChvG(ExoS)/ChvI involved in regulating the production of succinoglycan.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTIALVDDDRNILTSVSIALEAEGYKVETYTDGASALEGLLARPPQLAIFDIKMPRMDGMELLRRLRQKSDLPVIFLTSKDEEIDELFGLKMGADDFITKPFSQRLLVERVKAILRRAANREAAAGGTGPAKNADTPSRSLERGQLVMDQERHTCTWKNESVTLTVTEFLILHALAQRPGVVKSRDALMDAAYDEQVYVDDRTIDSHIKRLRKKFKMVDNDFDMIETLYGVGYRFRETA
The following text describes a protein:
Function:
Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate. Essential for growth on N-acetylglucosamine.
Sequence:
MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKEADQI
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MQITLKTLQQQTFKIDIDGEETVKALKEKIELEKGKDAFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKGAACSSTPTPAASQPASAAAPAPASPPLTYTPIARQNAPIPLPVPFSIPAVPAPAAPTSEPSTTTAPKEEKPEEKTDSPQETVSPSSTECSLPTDSSRPSLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLMGIPSDREGQAVAEPPQTLSSTPTQPLPAAAGAAATTTTPSTPSTGGNPLDFLQNQPQFQQMRQIIQQNPSLLPALLQQIGRENPSLLQQISQHQEQFIQMLNDPVPESGGQGGGGGGGGGGGRGIAAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDDD
The following text describes a protein:
Function:
Component of the stalk tube, the matrix that encases stalk cells.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MNKIYLILILFTFVGIILANVEKAEVSCTCDENCNDGNKCTLDKCNNGCCSNTPININDNDECTVDTCNPKTGISHTPVNCDDGNSCTADSCLCGKGCQHVPIACDDNNACTVDSCSNSTGCCHTPLSCDDNNPCTVDSCSNSTGCCHTPINVDDHNACTEDKCTQSGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLSCDDNNACTVDSCSNSTGCVHTPINVDDHNACTEDKCTQSGGVTHTPIACDDKNACTADSCSNSTGCCHTPITCDDNNACTVDSCSNSTGCCHTPINVDDNNACTEDKCTQSGGVTHTPIACDDKNACTVDSCSNSTGCVHTPLACDDKNPCTVDSCSNSTGCCHTPINVDDNNACTEDKCTQSGGVTHTPINCDDNNKCTVDSCSNSTGCCHTPMSCDDNNPCTVDSCSNSTGCVHTPINVDDNNACTEDKCTQNGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLKCDDNNACTVDSCSNSTGCVHTPINVDDNNACTEDKCTQSGGVTHTPISCDDKNPCTIDSCSNSTGCVHTPMSCDDRNPCTSDFCSWEKGCQHVALSCNDFNACTMDSCSNSTGCTHTPIACDDKNACTVDSCSNSTGCVHTPLTCDDNNPCTVDSCSNSTGCCHTPINVDDHNACTEDKCTQSGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLSCDDNNACTVDSCSNSTGCVHTPINVDDNNACTEDKCTQNGGVTHTPIACDDKNACTVDSCSNSTGCCHTPLKCDDNNPCTVDSCSNSTGCVHTPMNVDDNNACTEDKCTQNGGVTHTPIRCDDLNSCTADSCSNSTGCVHTPINCDDNNKCTADSCSNSTGCCHTPISCDDNNPCTVDSCSNSTGCCHTPINVDDNNPCTEDKCTQSGGVTHTPIGCNDNNACTVDSCSNSTGCTHTPMKCDDNNPCTIDSCSNSTGCVHTPMNCDDGNFCTLDSCCSTGCTHTPIIIDDNNPCTVDSCCNSTGVVHTPVDCNDNNVLTCDYCSIKQGGKCIHVPMTQCKTFGKCGDDL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.
Sequence:
MVGVGPKRPPSRKGSMSDVPQNLLEHIKHFEEIFTVDTATLKKIVDHFVNELTKGLSVEGGNIPMNVTWVLGFPDGKETGTFLALDMGGTNLRVCEITLTEEKGGFDIIQSKYRMPEELKTGEAEELWQYIVDCVEQFIQFHHENENLSKLPLGFTFSYPATQDYIDHGVLQRWTKGFDIDGVEGKDVVPPLEKVFKERGLPIKVAALINDTTGTLIASSYTDPAMKIGCIFGTGVNAAYMENAGSIPKLAHMNLPPDMPVAINCEYGAFDNEHIVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIFRLALVDILDTQPGLIFKDQDTSQLRIPYLLDSSFPAAIEEDPYENLIETAELVQNMLKIKATRSELELMRRLAELIGTRAARLSACGVAAICKKKNIESCHVGADGSVFTKYPHFKARGAQALREILDWAPSEKDKVTIHAAEDGSGVGAALIAALTLKRVKAGNTAGIRDAQAMLAMC
The following text describes a protein:
Function:
Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAFEIDGKCLCYHGPLLYEARVLRVYDPASQTYRDRTRTGVPLEEEDGLPAESRGREHWFVHYQGWKSTWDEWVGQERIRPYNDENLALKRQLVQDAKAAAAAAKRAKARPGKRERSPAPAAPAAPAQGPRLAVRMPVELKALLVDDWERITKERKLVALPCAPTVGDILDAYYRERTAQLASPVAQTLLHEFVEGVHLYFDQCLSHLLLYRLERLQFDEACGGAAPAASGLPAPPEPRPSAVYGGVHLLRLLSMMPELICGTTMDEKSCHTVVAQCESLLAWMATHADDLVSGDYINTSAQYEGVALGM
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MKFPQFDQEIAISYFSDVKNAGQIRNELLSGNPDYQVAFINANTLLSSKHLLAAVYRAVSDQEAGSMKTKNVHSEVLFCLGGNNNIMDSLRRFGIQDDTTNIVAVKIGGGEYTKLVEGTEEPFTDEQIAKNTDIKLVKKVYKLPGTVSLDDRAQVETAAIGALLLRGFS
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
MFSWVCKMAPSFHLSGNKIEIIEGPREFHEKLKELSLKSKKRILLGSLYLGISPLEQELVDSIKDALRESDKTDNGKLRVTVVLDYMRASRGFKNSRTMLLSLINHHSSPSSTLPSSSSLNLYLFHTPDLRGWLKKCLPERFNEVVGLFHIKAYIFDDHIIISGSNLSETYFSSRQDRYVLIKNFKPLADFYHQLFDIISKYSFSVGSDDSLHYGDVPHPYSETNKKFRENMKGEVEELIHSYMIAYNNNNTGNYHNDDNDIDNNNDERSHNETDTVIYPLIQMGPMNVTQDEKLTTKLLTHFPKNSRVYLASGYFNITDEYIDIIIRSSSSFFHILTAAPQANSFYKSAGLSGSIPPAYTYIASRFLEQVKNSQQTSRIKMYEYNRPNWTVHSKGVWLYPPSDQNGPDLPYLTLVGSSNYGYRSVKRDLESQLLIITNNKNLQMKLHQASQKLCIQDSYELTADVLKEDDRKVPYWVTLVAPRVKTFF
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MAGGKKSDKWKAGGGKKGKGTKGEGKKKGGKKKAKPKLSEDAKNRQQEQRAAVEEERRRMREELINSFLRHKLLKEQNLTRLNQSKLIEKWRHVLRDAKSQELSRELELMKLDFDKRYSENITEINRLMESLLQNGLDFVQICNIQKLETDRTFDEHVSRLNILANVYQQESNLFKATIVTDYTSAMTCHQQEKRSLLSTISTLQSHYRESYTAQKANFQIRKDDIINQGLEEEQTICQNLERRLGKKNPRVYKVVLCVERSNVVPRRLEHSWQQLHENCVDSGELDEQRWALYSLLRRRDQIAYEQQRIAEIRLEKLAKAVNQIQEKRNCHEQGAQQLMERRNELHERRERWRFRLLKQQQQHAERLKAVAASSSDAAEHLEQLVKQGVLILRSAQRCLLLKPQQRQSSSSSSDSPPANCLLSEPFQHFWTRFNQAYLETVLLQRHQAAIVRGRTAETARLKKEVNIPTCWSLNGTTLPIHPEK
The following text describes a protein:
Function:
Required for the Mettl1-dependent formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the Mettl1-wuho methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for binding of nanos mRNA and repression of translation by the mei-P26-bgcn-bam-sxl complex. May cooperate with mei-P26 and nanos to derepress the BMP signaling pathway. May cooperate with mei-P26 to suppress expression of a subset of microRNAs. May cooperate with mei-P26 to regulate bam expression levels in germline cells during gametogenesis. Required to promote mitosis to meiosis transition during gametogenesis. May regulate germline cell division in part by regulating ribosome biogenesis; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MAPFVARGNLIVIGSEVSILTIDTTTGILKHASIPPLSENHAEKTKQEPQTENKQPDKISQNTNSEDNSHLNMGTCLALSMCASFLAVCTSDKNLTVWNLSSMDVLKQWKAARKVSSLTFISDSSQLLVADKAGDCFTYSLNDPTGQGKLILGHLSMLLDVVVSSDNKFVITSERDEKIRVSCLPNAYNIHSYCLGHTEFVTSLAFIQNNLLLSGSGDGTLRIWDYLDGKMLHTENLKETSDQEMEKAVRSVVVFKASETMSIAAVLLDRIKTVFLFKIIGAETKFQRQTLPFVAQPLEAAFTECGSLYVLTDSASNPIEYFGKDESFLYTLGESAIVGNLIANPSHLKIVQECVQTCNGDLKPLFKRWFDNVQVYRERKIEQQVKPKIENSDVTSSPKRLRVE
The following text describes a protein:
Function:
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Sequence:
MPVSETTDRQASNGGDGPALPINELFYSLQGEGKLAGTPSVFVRTSGCNLRCWFCDSYHTSWEPTHATMSVDDIIAEVQSYEHADHVVLTGGEPLLHDDAVVLLDRLAALGYHTTVETNGTIHRDAPIDLASVSPKLASSTPTAETDPKGDGEWAARHDARRIDVATLGALADDYDTQLKFVVTDPSDMPEIESLLAEIRTATDTRIGDEDVVLMPEGTTHAELDARRNEVATLAMEHGYRYTPRLHVALWNDAPET
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MAATTLRAQLNAHITGMYTDGVVDEDTFEELRDEGTAVEVSRLFIYDASKIIDDIDILMEEPEVDFDEVEALTQHLMRCTSSLSTALMLFFIWMCRHGVRTSRHGRTIEVRVVLQAPYSHR
The following text describes a protein:
Function:
Probably involved in translation.
Sequence:
CNAKNEREEHESSGDLERNDPQSQETRRCRRVAVVEVGEQQQGHQGVAAAAAVVRAVGRRLVVRRGGGGRRRRRRRRPSAAAAAAGEQEGKVRQGPRGVQEQVPCPPPRRGGSGGGGRREQRQQVDVRGAGGVRPAGGDVRRVRGRGGGGRRRGRGAGGDYVHVRVQQRNGRKTLTTVQGIGGEYNYAKVLRDLKRELCCNGNVVEDKELGKIIQLQGDHRNSVSDFLAKAGMVRKDNIKVHGF
The following text describes a protein:
Function:
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Secreted.
Sequence:
MNEIAYNKVAAGGVERQIRILKWTVAGLFATVVCLTGAFVYVTVNLFSKLDAVDRTEPWTGGGRLGPGDTGSNPTIQEIVAEILKNETLWRDKHTDTSRRREFVPQGPFTLHNDSSRAYLAKPMAHLTGKSGSARHTRRHGRGERTVRIQSWESRQGLATVANGMTHREGAIRVPVDGLYYVYSQLYFRHVRLPATDGSSAEDHTGDHQLLHSTFKKSATYPEKQEIMKSARTRCWSKDSQYGLLSSYQGGVFRLRAGDRLFVQVSNVALVSFEEAASYFGAFMI
The following text describes a protein:
Function:
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Sequence:
MTTDEDLIRAALAVAATAGPRDVPVGAVVVGADGTELARAVNAREALGDPTAHAEILAMRLAAGVLGDGWRLEGTTLAVTVEPCTMCAGALVLARVARLVFGAWEPKTGAVGSLWDVVRDRRLNHRPEVRGGVLARECAAPLEAFFARQRLG
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MTATGMYQVVLNSKVKMQHRGPRLHNLIIAMALSFCVLAFRLFAISRQDHQHEVRPVFLDNPLPLKNEVPRNTSDLIAKLAAVTRIAANGSNMTKVFSSEKQLLWNKEHPCSSRREIHSLYSTRKSTHDIQINSNWVSILQEYAKLHRTCVLQMGNVTDFFLKRKHIEGCKFVVAGVSRGSGIGNKALSIVSATVYAVLTQRILLVPQAAAAPGVFCEPFEGSSWTVDPDHIWTKSKKRTDLWDTLAYFHKRVDARALSEAMVKPVYAVSTTENWDAQPEPRFFCDTEQAQYTQVQWINFRNNFYFVPKLFAVPSFRPLLEDIFPHRKVLTQLLRTVMLPCDPVWERVKQVHDSHFRHSDRLVGIQERYFQGKSEFDLLHTTMEENVVSCLLAEGLLPTPNSESQPRTTTVPQEMDEPIVPSNSPEVLNSLNVTTIFITSLYQSLADRLSRDYVLTTTESDDPVGVVQLTHEETQNFGVEVDKHALVEILCLSLTDNLVLTPQSTFGALAQGYGGLVPWFIDLRPETQTPCVPAT
The following text describes a protein:
Function:
Diacylglycerol (DAG) and triacylglycerol (TAG) lipase that is required for proper lipid homeostasis in the central nervous system. It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3-DAG downstream of PNPLA2/ATGL. In vitro, also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P (By similarity).
Domain:
SAM and DDHD domains together are required for phospholipid binding.
Sequence:
MSSGESHQEQLSQSDPSPSPNSCSSFELIDMDASSSYEPVSPHWFYCKVLDSKELWIPFNSEDSQQLEDAYGSGKDCNERIVPTDGGRYDVHLGERMRYAVYWDELPSEVRRCTWFYKGDKDNKYVPYSESFSQVLEDTYMLAVTLDEWKKKIESPNREIIVLHNPKLMVHYQPIAGSDEWGSTSTEQGRPRSVKRGVENIPVDIHCGEPLQIDHLVFVVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENEQIGRVEFLPVNWHSPLHSTGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDILTNQKNSIGDIDSEKGSLSSAEDRGDASTLEEDLKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSARKNSVSINRPAMSASEVNISKENGDYLDVGIGQVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLRRIDPNYKFPTCKGFFNIYHPFDPVAYRIEPMVAPGIEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRGPYPALQASETAEETEAEPESSSEKSNEANTEEPPVEVKEEAPISVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGVFLDQPLQ
The following text describes a protein:
Function:
Plays an essential role in the regulation of calcium transport at the sarcoplasmic reticulum (SR), which is secondarily required for regular muscle contraction.
Miscellaneous:
MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the SclA protein from a non-overlapping reading frame.
Subcellular Localization:
Sarcoplasmic reticulum membrane; Single-pass membrane protein. Note=Colocalizes with SERCA at the sarcoplasmic reticulum and the diad, a structure composed of a single t-tubule paired with a terminal cisterna of the sarcoplasmic reticulum.
Sequence:
MNEAKSLFTTFLILAFLLFLLYAFYEAAF
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MASVRKRKMARSSVRKVTRRNRDKQRKVNIACNPIIEKNWDYNLTLAQNYKRLGLTAKLAPRAGGEEIDLSKVIQKSVPICSAFEDYDSESDVEQEKRNNDDALEDGEYDPAKIPEGEARIQRDENGDVVKVVYGTMKTVDVDEDISELKQKLEQDKVKTEVVQELESYASRPVNRRVRYQSSREEEWLGRLYEKHGEDYNSMARDLKLNIYQQSVGDLKRRMKKWLKAHHIDERQ
The following text describes a protein:
Function:
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Sequence:
MASTSVDDAVPVADGGTLLPPSGPLEVAINAQAALNSATAEPSHVHHLISHGADVNAPDNNGWTPLHTAAYHGQEEIVRILLAAKADVNARNKTSETPLHLAAKWPQDRVVEALLGGGADLAAVNRRGRTPAHVAALFNRHAILDRLLNAGADVNAVDGDGATPLHLAVRQGAPVEPELVKTLLRHAADLEARDKAGNTPLAHLPCAQDWLHWAAYEGREPLLRCLLAKPGVRPDVYSEEGLTPLHLAAHVNSVPLVTALLAAGAKVNAPSQPPSKTSGTSAKDMYGISLPGGSSAPGSIQSGISISSQLTKAYGAAKLPPGELTALHIAAERGSAELVRVLVGAGAKVNVQGERGMPPLHVAVWEGNTAAVASLLAAKASVGLKSKAGGFTAVHCACLSSRATPDLLALLLDNGGAAVIEERCQEGWTALHLACQSAPAAMVELLLQRGARPSAKGKAGRSAADCAAKRPEILQVLHVATGGKVPLPPAAALGLGLPSSVAAAAAAANGLLTGASAAAAAAAAAAGRSGRGSGRAGAAAGSGAGGAAASSSAVSGGGGAGSSSSSSSGLLPGTAAVLEPLESVEATLAALLADMGGALCSLQAGAMFGGHACSVDPVGHCIKPADKRLVVRCTLGCAFNFHLPCWKSAREVLKDRWPGFSGSLAPTGRYSCMAPTCPGYVREQLICDGAQISNASPSGPSAVPPSRLYLMAADMYDSLPPTAKPIGGGVPPPPGGGGANGLMGGGMLGPGGSGQQPANPPMQPQLPAAGAAAAAAGGLASAAAAAAAALGAAGGGAGSLGPSLQLAQAMMQAATAMAGGGGAGAGGANGAASRLAAALAASGGLSALLSGSGPPVPPAMSAREAAIIAAQTLGVSLDRVGGCVVEELSTDDEEEEEEEEEEEQEEGEGKEEEEREAAGKGEEEPKEQGGDVEEEHKQHKTEAGAGAGAGAGARAANGTGAKQPGAGGSKATGGKGAAAAAAASSSSKAGTKGRGAAATAATSHSHPHPHSHSNFRNQPLHVSSDAAAEMLQQLQGLQSAVAAVQSAVGASVHAAGSGRGGRHGGGGAAAASGLLAPLVPLEPTTLEPLPLLPQELPAAPDGTAGVEGEGDGGVSGAQAAMPPPRRPAANPIPPNPRRAPPPPLANGLPPVSPQLATPPPATSLDTPGVQQQLPVPPARRSSSGGNAGAPAASGGLVAANATAPVSAPSPAGPADAAAPVVAPGADASLAPILFSPMPATSNTSTSASGKDRDKEKEKKQEAASTTSKKQTTANGTSASAAPALGPMHGPPPPPGLVVTRNASKAAAAGSAAASSSSASSSSTSSGMRLTQQQQQQQHQHQLQQRHTAPALALSAGAFEPGGYARAVCPNLVPGAHRVTHSTSQPTSPSPASSPAGGVDIAAAAAAAAAAGGSNGSSGGASSGGGAVPAPAIATPTATSPISSPASAPVLPGGVKAERVAAALADLSLGLDAGSGGTGSSPHLLLTSGDVPLLASTPGMLEAWLKAHVAAHGELAAYRILPTAGAVAVTLADGGAAAAAATALAARPAMLVAPLTVAPLREFPDDEAIVEAGQQAARSRCPPGDRSWLRDMADLYLQLEGLPPPVRMTGAAAAAAGAAANDA
The following text describes a protein:
Function:
Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex.
Subcellular Localization:
Secreted.
Sequence:
MGFGKSSPFLAFSILVLCQAGSLQATPLRSALETLPDPGPLSEKEGRLLLAALVKAYVQRKTNELEQEQEQETEGSSLDSSRAKRCSNLSTCVLSAYWRNLNNFHRFSGMGFGPETPGKKSDIASSLERDLFPRGMPQDAN
The following text describes a protein:
Function:
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSIEIVPNQLRHLRACLLCSLVKTLEQFEMDGCENCEKYLHMKNNRDHVYDYTSSSFDGLIAMMSPGDSWVAKWQRIDKYVKGVYAVSVSGKLPNNVISDLKSKGVHCRSRDTSTSFVK
The following text describes a protein:
Function:
In vitro, is able to catalyze the NADP(+)-dependent oxidation of shikimate to 3-dehydroshikimate. However, has much lower activity than classical shikimate dehydrogenases AroE, indicating that shikimate may not be the biological substrate. Cannot utilize NAD(+) instead of NADP(+). Is not able to catalyze the oxidation of quinate.
Sequence:
MINKDTQLCMSLSGRPSNFGTTFHNYLYDKLGLNFIYKAFTTQDIEHAIKGVRALGIRGCAVSMPFKETCMPFLDEIHPSAQAIESVNTIVNDNGFLRAYNTDYIAIVKLIEKYHLNKNAKVIVHGSGGMAKAVVAAFKNSGFEKLKIYARNVKTGQYLAALYGYAYINSLENQQADILVNVTSIGMKGGKEEMDLAFPKAFIDNASVAFDVVAMPVETPFIRYAQARGKQTISGAAVIVLQAVEQFELYTHQRPSDELIAEAAAFARTKF