lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Also cleaves the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.
Sequence:
MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
Sequence:
MNKAINIKKTAPLEVLHSELPYTQDPTALFHALCAGRSDCLLLESAEIDSKQNLKSLLLVDAAVRIVCEGHQVTYHALSANGQALLNIIHSNLTDRIPCKVEKAKLTLTFSTPCDTLDEDSRLREASSFDALRLVQHSFDLTDHGKFALFLGGLFAYDLVANFEPLGEAPADNQCPDYVFYVAETLMVIDHQRETCQLQATQFQPGDALHSQLKSRMREIRAQVNQKLPLPSAQSLSDVEVTTNISDAAFCDIVRDLKQYVVKGDVFQVVPSRRFRLPCPSPLAAYQRLKQSNPSPYMFYMQDERFTLFGASPESALKYEMHTNQVEIYPIAGTRRRGKRADGSIDFDLDSRIELELRTDKKENAEHMMLVDLARNDVARISQAGTRHVADLLQVDRYSHVMHLVSRVVGQLREDLDALHAYQACMNMGTLTGAPKIRAMQLIRDVEQARRGSYGGAVGYLTGEGDLDTCIVIRSAYVENGIAQVQAGAGVVYDSDPQAEADETRGKAQAVISAILYAHQGKE
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors; Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLIKFETKSARVKGISFHPMRPWVLASLHSGLIQLWDYRMCTLIDKYDEHDGPVRGVDFHSQQPLFVSGGDDYKIKVWNYKSKKCLFTLLGHLDYIRTTFFHNEYPWIVSSSDDQTIRIWNWQSRSCVSVLTGHNHYVMCANFHPTEDLIVSASLDQTVRVWDITGLRKKTVAPGAGGFDDRNRGPGSTDLFGVQDAVVKHVLEGHDRGVNWANFHHSMPLIVSGADDRQVKIWRMNDSKAWEVDTCRGHYNNVSCVLFHPRQDLIISNSEDKSIRVWDMSKRIGIQTFRRETDRFWVVTSHPSLNLFAAGHDGGLIVFKLERERPPYVVHGNMLYYVKDRYLRTYEFGSKKDVPIMQMKNQNRSYISNLHYNQAENAIIACTTLPNQESCYYDLYTLPKSVENSSNPEVGNSRSSNGLSAVWLARNRFAVLDKTHTILIKNLKNEISKKISPPACDMIFFAGTGNLLLRDGDNVSLYDVQQKRVMNKVRVPKFKYACWSPDTTHVALLGKHVINICNRKLESICTVHENIRVKSGAWDDNVFIYSTNNHIKYCLRNGDSGIIRTIDLPLYITLVRGSNVYCLDRSCKIKILPINNTEYKFKLALVTRSYDQVLYMVRNSNLIGQSIISYLQKKGYPEVALHFVKDDRTRFGLALECGNIEIALDAARNLNDNLCWEKLSAVALQQGNHQVVEMAYQRTKNFDRLAFLYLITGNLQKLQKMMKIAEIRKDFSGQYQIALYLGDALERVKILNALGQKHLAYLTAATHNLEEESNTLKSNFQNGDTVPSMLEDAKLLRPPVPVMPCEGNWPLLTTRKSFFDTKASGGGGSMAAVVEDAEAIGDTGGWGEDADLDLDEGKNEFVDEDEIAGDGEDDEEGGWDIGDEDLELPPDLEVVEPTSAEEGYFVPPTKGVSQLQVWCNNSSLAHDHVIAGSFESASRLLYDQVGVVNFEPLKAMFLATYARARVAYVGLPSTPPLFGCPHRNWREAGARNGVPAIKCKLSNLVEKLQAAYQLTTSGKFQEAVEKFRKILYKILLLVVDSRQEVNEVQQLISICNEYILGLSMEIKRKEMPKNTLEEQKRQCEMAAYFTHCNLQPVHLILTLRTACNLFYKIKNFKGAGGFARRLLDLGPRPDVAKQVRKILQACDKNPTDTHELEYDEHNPFTICGLSYKPIYRGKPHVKCPLTQTTYLPEHKGRLCPVTQICEIGKDCIGLRISPTQFR
The following text describes a protein:
Function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Sequence:
MSHSDVSFIEVKDPTKPSVLFHEWIQEAKKFGGKISLMNLATASKNGKVSNRTVVIREIMPDASLAFAAQAYSNKIKDINENPQVAATILIPYVKNGKNVIKQIRLSGTAEKLSQEQCRAYFEKESLSSKIRAWVCQKCGPVDWKDLKSEHDQLLKEVVENKKVIEMPETQVAHKIVPYEFDFYFSEGEAIADRVLFKLVGAKWDCQRIMT
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDDGDDFVINTWEPSPSVPKKAPASAKADGGGKPGNAGAGKPNGGNGHAANGNRAHGGQQQQQRNGKAFGRDGSSGARGDSGSGGQGQQRNGGGGAGRQDGGAWQAGRPSGGGAGGGGGAGGGGRQRQQPGKDRFKMRAGGRAMDPDDPDELLRSEAPAEEQDDLAEVLGLVAARERALQAEAEGAAGAGAGGGKRRAPAEEPEGVVDFDDDDGGRKRRRTDGAGGPAKPAIKATGRGNFTPGTATHAAANPAAAAAAAAGGAADADASWQGLGLAASLSGQLESLGFAAPTPIQKLVLPVLLSGRDALVKAQTGSGKTLCYLLPIINDLQAQQPRISRGEGTYAIILAPTRELSIQVADVANAILKRYHWLVSGLLIGGENRAHEKARLRKGVSLLAASPGRLLDHLEHTASFRTTELRWLVLDEADRLLDLGFEAKLRQITELLNKRSAAGMEAEAAGGAAAAAHAAVNDHADDAQDAEGDFDFVAEEKSRRRQAAAAAGPGPGSAGAVAAAAAAAASQRRTVLVSATLHKQLGALAELALRDPAVVGFDVKQTKSGPQLIGGADVGSGPGGSGATAGGEGEGVSYSLPASLRQTWLEVPAKERLSALAALLKSRTARRRPGGTKIVVFVSSCDGVEFHHHLLADLWEAVAGGPLLPRTCRLFKLHGDMPQSQRTETFAGFSKEGDGVLLCTDVAARGLDFPNVTTIIQYDVPGAPAEYVHRVGRSARMGAAGEAVMILMPHEVPYVNLLRSRGVMLEALGWDGLARFMPTPSFDADGGGGGGGGKMSKKMAAAAEGLGSAGAARQLAAQLHRQMSAAVARDPHAAQLASDAFRSYVRAYATHSGDLKRVFAVRNLHLGHVAHAFCLTETPTLVGSSGSAADRKRRKREQSAAAEADRRKKMKRAARKVSA
The following text describes a protein:
Function:
Component of the core of the flagella.
Subcellular Localization:
Periplasmic flagellum.
Sequence:
MRITNMMQNNSLIHNLNRHQLNMDETQNQLSTGQRIRLPSDEPGRATNQMFFRSRLNELETFQRNIDDGNSRLQQIDGELDRIGSLFQRARVLAVQASNGIYQGDKGFELEVAVGKEIDEILRALVDIANTRDATGRPLFGGHVIERPPFEPIESKIKGLQGIELKNQYIGVEYRGDIGEQLREIEKGEYVPVTIPGNKVFWGTNMSITSKVDNSGYVVSSDQKFKIDGVEIHVSAGDTIDDIIDKINNSPLEVKANKLAQDNISLSSTAPHQIWMEDVEGGTILRDIGLVDSATSEPPNNYSKSATVTGLSVFDVMIQFRNDLIQKDQERISGRDLQDLDLAMENILRYRAIVGARMNRMEEHAQRVDFDKSYMTELLSKNEGIDFPETIMNMKWLETVHQYALNVGSKIIKPTLMDFLR
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
Sequence:
MSKFFNAWLQDQDCRTRIREIPWEGYHRASLISADDLALLQATASQPKIKQEQIWEHDTEKYVSLYLNLLSQLSRVDCLQATLVYLSDMIEDHEERIALLLDHAVNPYAALTPHLESPDYYIRIKALSLLSVLLEFHPTPPQDVLSTIGPMIARLTGSGDSNEQELGIELFEHVLRQPLARQAVWASAEESGASSNGETTQSNVISSLVQMMKSASRMTAQIQYQLAFCFWLLTFDVAIASQFNKRFSVIPLLTELARSAVKEKVIRILVATFRNLAEKAPEANLATMLVAGNLLPLIQNFSSRKWSDDELKDDIEWLKEQLEEAKRKMTTYDEYLTELESGLLRWSPPHTSEEFWSQNADKLNEKNHQPLKKVIELLSSASDPVVLAVAANDLSQYVKHSDVGKRSAERLGAKPVVMKLMTHQDSDVKYWALVSVQQLVSQPWSY
The following text describes a protein:
Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Sequence:
MLLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFSYPQDGWTDSDPVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGTGTSRPVSQVTLAAVGGAGATALAFLSFCIIFIIVRSCRKKSARPAAGVGDTGMEDAKAIRGSASQGPLTESWKDGNPLKKPPPAVAPSSGEEGELHYATLSFHKVKPQDPQGQEATDSEYSEIKIHKRETAETQACLRNHNPSSKEVRG
The following text describes a protein:
Function:
Enhances the binding of the PAF1 complex to target gene promoters and plays a role in negative regulation of transcription. May function as an anchor to keep the PAF1 complex on target gene promoters, sequentially pausing RNA polymerase II-induced mRNA elongation. Inhibits FOXM1-mediated transcription of PHB2.
Miscellaneous:
MISCELLANEOUS: Encoded by the circular form of the long non-coding RNA LINC-PINT; MISCELLANEOUS: Suppresses glioblastoma cell proliferation and shows decreased expression in glioblastomas compared to normal non-tumor brain tissue. Induces growth inhibition and cellular sensescence and decreases mitophagy in hepatocellular carcinoma (HCC) cells with higher levels of expression in non-tumor tissue than in adjacent HCC tissue.
Subcellular Localization:
Nucleus.
Sequence:
MLWLPDRGSCSARSPSGMLRGAPGGWRYGRRCGRRRQSCCCCCCCSHVGAPLSFHREASLVSHDGHDIMKQHCGEESIRGAHGYKNK
The following text describes a protein:
Function:
Binds double-stranded DNA tightly but without sequence specificity. Involved in DNA compaction.
Subcellular Localization:
Cytoplasm. Chromosome.
Sequence:
MVAEEGIVFVGKKPAINYVMATTLQINRGVKKIVLKARGRSISRAVDVAEITRLKYFPGKLKITDLRTGTEEIIDENGSRRDISVIEIEMTQV
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPLEIILIIVAGFIVAFILAVGVGANDVANAFGTSVGAKVLTLKQACSKVTDTVRKGIVDISIYDNRTEVLMLGNIATLSGSCLWLILATVFKMPVSGTHSVVGATIGFALVASGTTGIQWKQLIYIVASWFVSPVLSGIVSCGLFYLCKYGILTKKDPIEPGLRFLPMFYAVTIVVNLFSIFFEGPKALGFHKIPLWGVLVISLGAGIITAIVVRIIVIPFQRRKIIGYNNNIKFVKKYDENEKLMMDEMKKKEQEKVFREVANKRLRENAIPKHGSFVADEKIRLKEIDVNNKSLPKHGSFVADDRTRIKERNELKISFKPNSQDGLNNDLFDDAHLVKRERSQSMIAATSTNIEAEIAHDEHKKKRFRSKSESATAEQRKKMYSGTINQLVHKRFVNADKSMILNIEMKYAASKEQKLQQEGRPTGEIVKMTRDAINDRPEQRQLFSYLQILSAAFGGFAHGGNDVSNAIGPLVSIWILGTAKSNIPENSYSQILILLFGGIGITVGLWIWGRRVIKTMGEDLAKITPSTGFCIELGAATTVLAASNLGLPISTTHCKVGSVVTVGWARARKNVDWKLFSSIFLAWVLTLPVAGGISAAVMAILMNLSIAKYGIGGSAGASGANSTILYDVLTNTTTITV
The following text describes a protein:
Function:
Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress.
Miscellaneous:
MISCELLANEOUS: Present with 2190 molecules/cell in log phase SD medium; MISCELLANEOUS: Although this protein promotes prion formation and it has a Asn/Gln-rich prion-like domain, it does not seem to have a prion form by itself.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, actin patch. Note=When overexpressed, localizes to punctate structures which are reminiscent of cortical actin patches. Transiently colocalizes with SUP35 aggregates during prionogenesis.
Domain:
The PY motif is recognized directly by the WW domains of RSP5.
Sequence:
MSASLINRSLTNIRTELDFLKGSNVISNDVYDQINKSLPAKWDPANAPRNASPASLEYVEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYVKPAFSGSNGPSNLPPPPQYKAQELQQIPTQNSAASSYQQQPFPPPSTNYYQQPQQQPQQAPPPQQQQQQQQHQSSHSHLKSFGSKLGNAAIFGAGASIGSDIVNNIF
The following text describes a protein:
Function:
Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import; Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus envelope.
Sequence:
MDPESVAKAFVDHYYSTFDTNRAALANLYQENSMLSFEGQKYQGSQNIVAKLTSLPFQQCKHHISTTDCQLSGANGMLVFVSGNLQIPGEEHPLKFSQMFQLIPAGQGSLYVSNDIFRLNYA
The following text describes a protein:
Function:
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2.
Subcellular Localization:
Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein.
Sequence:
MKPETCTSSVKAPGSSEPDRRCSAATFCLSLAGAQSRALFQRSSPFQPRPRSSRTADRTLTASCPGSPRFITAGTSRGCRNFLDDHFSVRTLRPRGPTNMRFFLALSGLFLLFSPGGAEPEPRADGEEESSCQGAFDLYFVLDKSGSVIGHWDEINDFVENLAEKFKSPMLRMSFITFSSRASTIMKLTENREKIRKGLNALRKEKPGGDTFMDLGFQSANEQIRKENFGTASVIIALTDGELLENHLIKAQQQAEEARSLGATVYCVGVKDFNETQLATIADTIEHVFPVLGGFHALGGVIDSIIKKSCIEILAAEPSSVCAGESFQVVVRGNGFFHARNINQVLCSFKINDTVTVNEKPAGVENTFLLCPAPVVDEVGKVIYLQVSMNDGLSFISSNVHITTTECFDGTILLITLLVLFLLLALLFMWWFWPLCCTVVIKEPPPPPPPEPESDDDDGLPKKKWPTVDASYYGGRGIGGIKRMEVRWGGKGSTEEGAKLEKPKNAVVKMPEQEYEPYEPKPKKPQTKKPPQSRKWYTPIRGKLDAIWALFRRGYDQVSLMRPQPGDHGRCINFTRVKDEAAAAKAPPRVHTPTPPPPDYRPAPRSVPSLPTSISPPARSPPSGQLPQVPPPSRTPPGLPCPPPSRPPPSLQL
The following text describes a protein:
Function:
Involved in the biosynthesis of beta-1,4-galactan. Beta-1,4-galactans are abundant polysaccharides in plant cell walls and are found as side-chain of rhamnogalacturonan I, which is a major component of pectin.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
MAKERDQNTKDKNLLICFLWNFSAELKLALMALLVLCTLATLLPFLPSSFSISASELRFCISRIAVNSTSVNFTTVVEKPVLDNAVKLTEKPVLDNGVTKQPLTEEKVLNNGVIKRTFTGYGWAAYNFVLMNAYRGGVNTFAVIGLSSKPLHVYSHPTYRCEWIPLNQSDNRILTDGTKILTDWGYGRVYTTVVVNCTFPSNTVINPKNTGGTLLLHATTGDTDRNITDSIPVLTETPNTVDFALYESNLRRREKYDYLYCGSSLYGNLSPQRIREWIAYHVRFFGERSHFVLHDAGGITEEVFEVLKPWIELGRVTVHDIREQERFDGYYHNQFMVVNDCLHRYRFMAKWMFFFDVDEFIYVPAKSSISSVMVSLEEYSQFTIEQMPMSSQLCYDGDGPARTYRKWGFEKLAYRDVKKVPRRDRKYAVQPRNVFATGVHMSQHLQGKTYHRAEGKIRYFHYHGSISQRREPCRHLYNGTRIVHENNPYVLDTTMRDIGLAVKTFEIRTIGDRLLRTRQ
The following text describes a protein:
Function:
Effector that promotes P.infestans virulence in Nicotiana benthamiana and potato. Attenuates cell death triggered by the pathogen-associated molecular pattern infestin 1 (INF1), indicating that the effector suppresses pattern-triggered immunity. However, it does not attenuate cell death triggered by a range of resistance proteins, suggesting that it specifically suppresses INF1-triggered cell death (ICD). Targets host MAP3K VIK in order to utilize or promote its ability to negatively regulate immunity.
Subcellular Localization:
Secreted. Host cell membrane.
Domain:
The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate.
Sequence:
MITFKRLSSARWGALLTSIAVLFFLAITKGADAKAGADLADIQAYRRLRTTTADAYYASEDRVFSVVKALKDLAHNAKLTFSLDKQLKVNNRFEVLRVKQVKTDVFSSSEFTDWAHYVAKICKRGRLPADRAIFKTMAAHYGDDELARMLATAKRTSRDTVVYQLKEIQQKSWKESGKSADDVYAILQLDAGGQNVLNNPGLPAWLSYVKSPSTDYIEALLLKLREQYDDVTVAKMIVSSQSGVNKRISGQLEKELSTAWRKNHITEMEVFQLLKLNDAGTTLLKNPILEIWFHYVWKMKRNDPYELLVSWFKKAGIDDAGLGKMIATAKQDDRNYWIAQTLEQRLSGK
The following text describes a protein:
Function:
Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV NC1 hexamer. Plays a role in extracellular matrix consolidation, phagocytosis and defense.
Subcellular Localization:
Secreted.
Sequence:
MRFMLLMLQLLGLLLLLAGGVQSVYCPAGCTCLERTVRCIRAKLSAVPKLPQDTQTLDLRFNHIEELPANAFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIFLENNDIWQLPAGLFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAIDCNCGVYSLWRRWHLDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCEVTGLPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVVNGGNHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVLLDCAASGWPQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQPNQLSAGTYRCEARNSLGSVQATARIELKELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTELVVGAARQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQADQPEDGLQISWRHDGRLIDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVTIRNNVDLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFPTGEARQLARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPNCTDMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVSTSLVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESWDGIDCKKSCEMAPPCYPIEVPPNDPRVRNRRCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQELRNLTSQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLLAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGEYQGYNPQLNPSIANEFATAALRFGHTIINPILHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYENPGVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLWQECGRCNSPPAIFDSYIPQTYTKRSNRQKRDLGKENDEVATAESYDSPLESLYDVNEERVSGLEELIGSFQKELKKLHKKLRKLEDSCNSADSEPVAQVVQLAAAPPQLVSKPKRSHCVDDKGTTRLNNEVWSPDVCTKCNCFHGQVNCLRERCGEVSCPPGVDPLTPPEACCPHCPMVK
The following text describes a protein:
Function:
Probable transcription factor that binds specifically to the core DNA sequence 5'-GTTAC-3'.
Subcellular Localization:
Nucleus.
Sequence:
MDRRNPFQHHHHHHQLHHHLIQQQQLPPPPLSTTATMDPGGGGGGGERIPQWSIEETKELLAIREELDQTFMETKRNKLLWEVVAAKMADKGFVRSAEQCKSKWKNLVTRYKACETTEPDAIRQQFPFYNEIQSIFEARMQRMLWSEATEPSTSSKRKHHQFSSDDEEEEVDEPNQDINEELLSLVETQKRETEVITTSTSTNPRKRAKKGKGVASGTKAETAGNTLKDILEEFMRQTVKMEKEWRDAWEMKEIEREKREKEWRRRMAELEEERAATERRWMEREEERRLREEARAQKRDSLIDALLNRLNRDHNDDHHNQGF
The following text describes a protein:
Function:
Transmembrane reductase that may use ascorbate as an electron donor in the cytoplasm and transfer electrons across endoplasmic reticulum membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in the lumen of that compartment.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MALSAETESHIYRALRTASGAAAHLVALGFTIFVAVLARPGSSLFSWHPVLMSLAFSFLMTEALLVFSPESSLLRSLSRKGRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLATRHGQAGLLAVLWAGLQCSGGVGLLYPKLLPRWPLAKLKLYHATSGLVGYLLGSASLLLGMCSLWFTASVTGAVWYLAALCPVLTSLVIMNQVSNAYLYRKRIQP
The following text describes a protein:
Function:
RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGSSMNSDRSRGPHAGMGKGFGAGKSSWNTNIWGDSNLKSGFDDQNLAETGFEGKSGSGSLLPSSESDGWSSRPNLPWNTVNTTSASLSRGQNNGMTASPISTRPNDRSAPALSDTVDSTSYFSIPRSSGIGSSSGGGNHKTYLNAGADGISPCGDGLSFGNFGGLRSGDGRRHPNSSAFGGSPVGTGFPMKQGFTTLDTTRPDEITGSLTMSSLPQALPDTMSQPLARNGFAHASHNSASITSQRPTHASHPSFHSESQGFEGRFGGSSMDLSAEINTLQLNEGGFSGHPVSRPPYLSHSSYDGSLQRFKYQSAADESSYEAVGGYAGDGLSELPLGHHAGRSRLGEGSLSPTDLARMESTFYSALEAGAVPGSHYRNGSATRLSENQALALERKLRAMQHDQDLAHGAANSLQRIPYNTPAYDLAGYQAARLNALSGFYPVAQLGGLGSAGIIPRGHRDQDPAQVVRSPLLEEFRANSKGNKRYELKDIYNHIVEFSGDQHGSRFIQQKLETANSDEKEQVFREIQPNCLQLMTDVFGNYVVQKLFEHGNQSQKKILANQMKGHVLALSTQMYGCRVVQKALEHILTDQQASMVKELENHVLKCVRDQNGNHVIQKAIERVPSQYVQFIINAFKGQVSRLAAHPYGCRVIQRMLEHCEEVDRESILAELHACTAHLIPDQFGNYVIQHVIENGEEKDRSRMINVVLSQLLMYSKHKFASNVVEKSIEFGEESQRQQIISTLTSANERGESPLLGLMRDQYGNYVIQKVLGQLKGEEREGLIDQIRPLLSQLKKFSYGKQIVAIEKLIFDSTTLGANSLPPASSTTPPHSHKSSPQPSKRLVNDVENSRAPVVGAAPPTPPPTDNQGHTHGPAESKNLAKSTVTSLSVSESASADSNGSVPVSAST
The following text describes a protein:
Function:
Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. May play a role in hair cell differentiation and follicle morphogenesis.
Subcellular Localization:
Nucleus. Note=Found in nuclear bodies upon PIASG binding.
Domain:
Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.
Sequence:
MPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGHEVVRQAPSSQEPYHDKAREHPDEGKHPDGGLYNKGPSYSSYSGYIMMPNMNSDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPEIPTFYPLSPGGVGQITPPIGWQGQPVYPITGGFRQPYPSSLSGDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGTGPRMTAAYI
The following text describes a protein:
Function:
Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts.
Miscellaneous:
MISCELLANEOUS: Members of the WAGO (worm-specific argonaute) subfamily lack conserved metal-binding residues found in other argonaute proteins and probably do not cleave target mRNAs directly.
Subcellular Localization:
Cytoplasmic granule.
Sequence:
MSPHPPQPHPPMPPMPPVTAPPGAMTPMPPVPADAQKLHQSTGNDACIKRLQQLNVEDGAKMYMKPTEPGKMGRPVDIQTNVFGIEVTKETTVHRFMVHAKADLTSTKEVTFTKKGKEDFVVQDRRDKCCNIFFLAVEKNPEFFKMKDGNQIVYDGQSTLYTTVNLFSELDANGTKSKVFQINGADTGNDDLKTLPCISLEIYAPRDNSITLSSENLGKRTADQNIEVNNREYTQFLELALNQHCVRETNRFGCFEHGKVYFLNATEEGFDQRDCVDVGDGKQLYPGLKKTIQFIEGPYGRGQNNPSLVIDGMKAAFHKEQTVIQKLFDITGQDPSNGLNNMTREKAAAVIKGLDCYSTYTNRKRHLRIEGIFHESATKTRFELPDGKTCSIAEYYADKYKISLQYPNANLVVCKDRGNNNYFPAELMTVSRNQRVTIPQQTGNQSQKTTKECAVLPDVRQRMIITGKNAVNITLENELLVALGIKVYSEPLMVQARELDGKELVYQRSVMSDMGKWRAPPGWFVKPATVPDLWAAYAVGNPGCRFSIGDVNQLVGMFIDSCKKKGMVIKPPCETGLYSTEKIMTQLEKVAASKCKYVLMITDDAIVHLHKQYKALEQRTMMIVQDMKISKANAVVKDGKRLTLENIINKTNVKLGGLNYTVSDAKKSMTDEQLIIGVGVSAPPAGTKYMMDNKGHLNPQIIGFASNAVANHEFVGDFVLAPSGQDTMASIEDVLQNSIDLFEKNRKALPKRIIIYRSGASEGSHASILAYEIPLARAIIHGYSKEIKLIFIVVTKEHSYRFFRDQLRSGGKATEMNIPPGIVLDNAVTNPACKQFFLNGHTTLQGTAKTPLYTVLADDCKAPMDRLEELTFTLCHHHQIVSLSTSIPTPLYVANEYAKRGRDLWGELTTKGPIEAKESQGERLKELTKEIGYKQTDLNQKRVNA