lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MIATPLKHSRIYLPPETSSQRRNLPMDAIFFDSIPSGTLTPVKDLVKYQNSSLKLNDHKKNQFLKMTTFNNKNIFQSTMLTEATTSNSSLDISAIKPNKDGLKNKANYESPGKIFLRMKEKVLRDKQEQRSRNSSLLEPQKSGNNETFTPNRVEKKILQHTYLCEEKENNKSFQSDDSSLRASVQGVPLESSNNDIFLPVKQKIQCQQEKKAPLHNLTYELPTLNQEQKNFLAAEAPNKTLTRAQLAKQIFHSKESIVATTESKKDTFVLESVDSTDEQFQNTNAETLSTNCVHIKNGSLLMVSDSERTTEGTSQQKVKEGNEKTVPGETGLPGSMKDTCKIVLATPRLHITIPRRSKRNISKLSPPRIFQTVTNGVKKNQVVQLQEWMIKSINNNTAICVEGKLIDVTNIYWHSNVIIERIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMFGFPENWKEHIDNFLEQLRAGEKNREKTKQKQKTGRSVRDIRKSMKNDARENQTDNAQRATTTYDFDCDNLELKSNKHSESPGATELNMCHSNCQNKPTLRFPDDQINNTIQNGGGDDLSNQELIGKKEYKVSSKKLKIGERTNERIIKSQKQETTEELDVSIDILTSREQFFSDEERKYMAINQKKAYILVTPLKSRKVIEQRCMRYNLSAGTIKAVTDFVIPECQKKSPISKSMGTLENTFEGHKSKNKEDCGERDLLTVNQKIKISNLEKEQMLTSDFKKNTRLLPKLKKIENQVAVSFYKHQSSPDLSSEESETEKEIKRKAEVKKTKAGNTKEAVVHLRKSTRNTSNIPVILEPETEESENEFYIKQKKARPSVKETLQKSGVRKEFPITEAVGSDKTNRHPLECLPGLIQDKEWNEKELQKLHCAFASLPKHKPGFWSDVAAAVGSRSAEECQRKYMENPRGKGSQKHVTKKKPANSKGQNGKRGDADQKQTIKITAKVGTLKRKQQMREFLEQLPKDDHDDFFSTTPLQHQRILLPSFQDSEDDDDILPNMDKNPTTPSSVIFPLVKTPQCQHVSPGMLGSINRNDCDKYVFRMQKYHKSNGGIVWGNIKKKLVETDFSTPTPRRKTPFNTDLGENSGIGKLFTNAVESLDEEEKDYYFSNSDSA
The following text describes a protein:
Function:
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
Sequence:
MTRVDFYVIPSADPSARLQVACRLAEKAWRQGMQVYLHCADEAQRSELDGRLWSFRGEAFIPHSLAEEDAEAPVALGLGEPPGNHRDLLINLTLEAPGFVPNFSRVAELVVEEPAIRQAARDKFRFYREQGYPLQDHRLPRI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MENDETTSCLLCGEPFSSSNALSQHWKDSSCKMSSIPAHSTQTTSAIVSTTAQMATVVRVPSASVQTHLDAASESHIPEDTGSTNLERKGRGDDGEESATSADGPTEVVEAEPLKDSSSVAVSSSVVPVSILLAHQVGVVTDSAKDDNEGSLSAGHFSHIPEEEAHIEGVIHQDSELSQIPETVHLQPDTLLGQVAMEIHIPMHTQLIVSDYIEENGQTESSSEIYFIEGKVEGLDTEDRQSAIELNVPKEAWEFEEKCEKDDLSVQTEVKLCRTSKVQKYCCEKCGKTYSKSSNFYRHQNVHFGIKFPCDLCGKVYSYRETLKAHKECCHREPVFCGVHKCKYCPRQYSSAIRLGVHLRSHTYDKPFPCSQCSKTFSSNVGLRRHQIVHTSVKDFQCKTCSKRFLRKRALEKHKIIHLSDRTYTCSLCSKVYSDQYSRWSHKCNHYPDRPYGCQFCLKRFKSPSALQVHERIHTRAKIHACTKCSYTCGTSLELKMHLRSHWQVDVKDTQTLERNQCKECGAKFTQRSTLRAHERTHSGEMPFVCPSCQKPFTYYSSWKRHLQIHKGEKAHRCKKCGKGFTKGLYLKRHRNGCCHGHSISGKSGKVRKKKRTSKVVESNQVRNVRLESSNTPIQSKRSEAGESDTSKHDKENFALHIGGDQNELTIDSNPLTVDLKPFTCEVCGKMYKSKSNLHRHLKTHQDKKPFSCDHCEKSYSRRPILKEHLLMVHGEGPTKPLFQCTDCAQSYPTLRRLEIHRRKHTGERPYKCKYCVKMFKEPSSMKRHEIIHLGLKPYKCIICQRGFSDKGNLQKHELTHGIKGEESRRNVETWKPFSCEVCGKSFKQLGYLRYHMKMHESKLSFSCELCDRKFSGAANLKAHLKTHSKKPHGCDKCRMSFRKESKLLGHQDKYHNVKKCFVCSKCGKVLSTKASLQRHENNHLGLKPFKCPSCPSTFSEKIILKRHLKTHKDDGSVLFCKECDAIFTSKDSLDEHVDSKSCLKTQKCEKCEKMFTSLMGLSQHQRSHNSVNRNSSSGASLKSKVYVCDICGNHFPKKKMLSAHKKAHKRNKKGDEKISKDATR
The following text describes a protein:
Function:
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MLNYLRYQSVKSILAKYAWASSPTNGSSFSTPRLDLMDYTYGLGLATYLCSKEIYIMQCKFYTGLSIAIMGVYAVKKLGCGTAKFLDGEVSKSYAEMNAGRDIDIEKAKAKIVAGKIEQDRALAMKMLFDSGTPPRGKTLHFSLKFSYSNQLVRVFSEYNLHLGEYSPWLATFLSSLYLDDTKDLVNFPRPCRQEYTVKVRMGFIPDEWFQLFCSKTGKLLMETTFLCL
The following text describes a protein:
Function:
Could be involved in insertion of integral membrane proteins into the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the inner membrane via a putative N-terminal amphipathic helix.
Sequence:
MAPPLSPGSRVLIALIRVYQRLISPLLGPHCRFTPTCSSYGIEALRRFGVIKGSWLTVKRVLKCHPLHPGGDDPVPPGPFDTREH
The following text describes a protein:
Function:
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). Has a role in meiosis.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence:
MDFFEDNNPFSGSDNRSASSAVNVEPKVEPSQHQGSSSVKENAISQPNESFQSRNMFFQKDVDSVVDSALDPNGIVITGAMKAESGSHIVYIIKLQDSEIHHRYSEFASLRVQLSRLYPTCLVPPLPDKHKIMDYLINVTKNQRMSRMLEERKRLLQLFLRRVAQHPILGLSEVFRKFLSRHVSWKEVLHSPPISCLPKDLLKAPPADPSSKENAELYKELPIPSKTLVPRDNYDDVGKNFLMLEDTLQQYSIVAQEESNLFNQIVLSNSKYCLAHSTLGAMFNALSLSESGKLLTALEKVGQANDHTCLASIDFMHNFVIAVIEPLQELSKDAKNMRHIFIFRKMKFIQQVMVEELLTRKKSFLHLLERRERHAARLQQAIGEVDGDVILNRESEATLGVNNAQTSRSTIPEEDPLFNDEESKEPSVPLMGTDQPLENYHDGNGEQTEECLRDLRHNQSQDFETVSQDTSLTSVTVLPRTIRDVFDRIRFVLNGLTDNNVEVSRHNNIGRTAESVTHLTDMLLITTKDVAFVTDRVNFEFQRYQDTHRQDLNRILNRLTDSHIDWANRNLRIWNSVQESLKTYVS
The following text describes a protein:
Function:
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKIGFFSGNPSVETVKGFLHIYKNNEMTSLNQGISRSQTICMLAVPAKLTCIDLLQFVAPSEEFIENIKIIRDASPNQYMALIKFKNQAHEFYNTFNGQQYNSFEEEVCHLVYVAKVEIVKSSEGASLACPGLTELPKCPVCLERMDESVEGVLTILCNHSFHGSCLSKWSDTTCPVCRYLQTPETTTENKCFMCDSRESLWICLICGHIGCGRYQSSHAYRHFEDTNHTYSLQLGTQRVWDYTGDNYVHRLVQNKTDGKLVEFVGDDEKLDSLTLEYTYLLTNQLENQRLYFQEKVTRIETEAAAQVAEEEERSKKTLEECKKLEMKLADCEKEKRNFEKKYNQVVGKVGKLVNELKEEKELNKCLRENQAAWQEKVIEIENKFQESEKIRTTEVRELQEQVADLMHHLQAQEAIACAPQETRQELQEGQMFVGEGSSSQNRKPRRKHR
The following text describes a protein:
Function:
Immune regulatory cytokine.
Subcellular Localization:
Secreted.
Sequence:
MVALSALVSTVLVCILMMKIKIIESSGHHCPVSLDIQEFKKYHESVKEVLHKKDVITDVSLLKAKVLNQIHPSEQCCFLLKLGRFYMNNIFPKLEISSIKEQKGLNHLANSVLGLKIELKHCHSSMRCPCGDQSHKIMEDFRETFYQMETEAAIIKAIGDLNILIRWLEKNYQG
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Domain:
The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
Sequence:
MLQDESSRSLPRSALIRRRLSLFLQSHALMYSFLWSESAKKSLLNEVFSALLGYDHTLWNTLLPERPTIDASFLLRRAQGHSEGDEYRHGTCESKCGHIFRKGEVFYRCKTCSVDSNSALCVKCFRATSHKDHETSFTVSAGSGGCCDCGNAAAWIGDVSCKIHSHEEDATISNDMIDEIPEKLENSIQTTIDCVLDFVLDVFSCSPENLKKMPTLESILQDEKTSRLSENKYGDIDDSCNMYSLVLWNDEKHSFKQFYEQITTALELPNNVFGKKMANIINDIGRACIVTETNIKELLKIGQKLAQINLAVSIRSMRDIFREESCAVLLEWLADIAGSSICGKRNYFSSVICKELVRPWNCGLHNSDLTFRLSLRSLALPEIVAIDSPDIFLNEDHINSSGPSDTSSHMLETDESSIHSRHWYPSNSLPDVLSYASRVRFDYFFLYDLKLWKSLRYKLQELYLGYFITQPGFKEIMGARIAISYRRLAELFLLLDREPEHSVIFFSMQIFTVADVAKLLVTEYDFLTTINATLYTFFTYKKLNTPNYVDQHAMIRTDSAAFHSRRYIHIFHHIQFMLSIPCVAEIVREDLKFLKQYADFFNLFQGMCPYTRAVSQHVEWENDSWMYVLNVSLQVAKLCRHVGNVFMELNTNKLANAINYLISLILYPKARNESWTNTESLTTGITVDERGNSKLIEYDIALQPVSFHHPLHWLLVYLLSFYVERDNYKLLWTQLDLLAVTDHPLRVCAWLSQMRAKLWIRNGTTLRDQAHHYRNLSFHEYTFDLDVLLLQLTLTYGDPDAILPSFISRFQLEDQMYGRFFVPHKHYDVSQVTIMMEEFLLLLISIVCNTAVLDHWDITRRIEYGIAHILCFRPLPYSEITKRTCEHLLEHKQFESTLKKVATFRNAEGINDSGSFTLKDEYFDYVDPFNIHYSRNQREEAENILRRRYSKQHSKHLESVVYEEYHPILHSNITIPILQSDSFVGILWHTIVYAYIYPYDQGKLEGLVNTALHACLLVLMSEKGSEPIFSKKICENRFPVVEGLQEYCNSPDVTLFSVLCQMKNHRNFVYVKEKISLIMKILKSEVPLLYEPVYAETLSISSSKIVQSLSDAEQQEQHLAKVRMAKERQARIMEQFRMQQNKFLENHALFEASDCEMDEADEFSVTSSVSTKLFLDPPIDTCLLCQEELKDKRPYGTLVFVLRSSVLRLFPADDANYVSEVLDIPDSLDHEIQERPFGLAGKRKKVLDSTEAYDYDNYYYEKKGNELHQLKDSFNGFPPDQLDRGLHATGCGHFMHIDCFKNHIATVTLATRANPYRNHPHNLSMKEFLCPLCKALCNTIFPILWRPKEEINFQEAGVLTAPLKNWLVSKTFSFNKDLNQQLLDIETSPSEHTQSYNLNLLDVLQHTLRDSLKDIYTLNTGADNSSDNVEENADNLFQSSVLDHVHFKSVVNNEVPADERLAISDDIFELYRRLDDVIDLNSSLYSDDFIPVNGKLHNVVKLFSYSLCQVEASTRGHIKCSSIPADIWVHNLGKNQQVFLRILSESIKTYTLLCAHDSQKRIGGSIQEFEFISFCQQKRIFGRLLPSLDSPVTKSITDDRVEPLLVKDTFREFAEASVSGLLSCDESFHYLTQLYYTADIVRNLWILLSQRNSLLKCMESVEFEAFDYEQLKGFEHLVIQIWKSLRVDGAGLINFDCCTEDDLNNPHLLFTLYKLLERFSLIFLRKCALLWYCRYGVSFETQPNLNFQNSELSRLQTKMHIPGVIELSNHLCLTASSTEWSLIKHWCNFFTETGPLCDFPRAYYPGIYELVSLPYELDKVFELLLARRCSKCLTEPMEPAICLFCGKLLCFQSHCCSFNGIGECNLHMQQCASDIGIFLIVKKCAILYLNPPVGSFSVAPFLDAYGETDLGLRRGRSQYLSQKRYDETVRTMWLNGSIPSYIARQLDANPDTGGWETL
The following text describes a protein:
Function:
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Subcellular Localization:
Nucleus.
Sequence:
HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFCESPGTVFRE
The following text describes a protein:
Function:
Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Up-regulates human DCR3/TNFRSF6B by directly binding to its receptor. Globally induces a proteasome-dependent loss of SUMOylated proteins in the host cell and the loss of promeylocytic leukemia nuclear bodies. Improves the stability of the triplex capsid protein TRX1 by reducing the ubiquitination level of the latter. Mediates evasion of inflammasome activation and antiviral responses (T- and NK cell activation) during EBV early lytic infection.
Subcellular Localization:
Host nucleus. Virion tegument. Note=Localizes to the host nucleus during the viral lytic induction.
Sequence:
MRPKKDGLEDFLRLTPEIKKQLGSLVSDYCNVLNKEFTAGSVEITLRSYKICKAFINEAKAHGREWGGLMATLNICNFWAILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTMVSSKTGHLTDDVKDVRALIKTLPRASYSSHAGQRSYVSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGASHTEARYSESGQFHAFTDELESLPSPTMPLKPGAQSADCGDSSSSSSDSGNSDTEQSEREEARAEAPRLRAPKSRRTSRPNRGQTPCPSNAAEPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRKKGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF
The following text describes a protein:
Function:
[CLE7p]: Extracellular signal peptide that regulates cell fate.
Subcellular Localization:
[CLE7p]: Secreted, extracellular space.
Sequence:
MASKALLLFVMLTFLLVIEMEGRILRVNSKTKDGESNDLLKRLGYNVSELKRIGRELSVQNEVDRFSPGGPDPQHHSYPLSSKPRI
The following text describes a protein:
Function:
N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins. Overexpression inhibits motility.
Sequence:
MIREAQRSELPAILELWLESTTWGHPFIKANYWRDCIPLVRDAYLANAQNWVWEEDGKLLGFVSIMEGRFLAAMFVAPKAVRRGIGKALMQYVQQRHPHLMLEVYQKNQPAINFYQAQGFHIVDCAWQDETQLPTWIMSWPVVQTL
The following text describes a protein:
Function:
Plays a role in mitochondrial electron transport and mitochondrial respiration.
Subcellular Localization:
Secreted. Mitochondrion. Note=Associated with membranes.
Sequence:
MRRLLFCTLLMTGLTQLCCRTQGSAPQDSTPGGRPGAALEVYQRTEVCRWPCRCPPQRPTCPPGVSLVRDGCGCCKVCAKQPGDTCNEAEICDPHKGLYCDYSGDTPRYETGVCAYLVAVGCEFNRVYYQNGQVFQPHPLFSCLCVSGAIGCTPLFIPKLAGSNCSAAKGRRKTDPPNCGRGTLQQQNSASYKTMSAYRNLPLTWRKKCLVQATKWTPCSRTCGMGISNRVTNDNANCEMRKERRLCYIQPCSRNTSQAVKIPRGETCQPTFQLPKAEKFVFSGCSSTQSYRPTFCGICLDKRCCVPNKSKMITVRFDCPSEGSFKWQMLWVTSCVCQRDCREPGDIFSELRIL
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MAKRDQKEASLLVLVAMVVVMVVLAVQVKSVVAAGEYTEAMMKVVREQVNAVNFTGNDARPGLIRLMFHDCFVNGCDGSVLLMTSRESSADGTTEKDSGFNIGLRGFEVIDKIKEKLADYKVTCTDAVIYAAREAVYLLSNGKIAYNVDGPGRKDGVISRSEDPEKYLPTPSSDFAVLVKKFTDKVVFTEKDVVALSGAHAVGVAHSTTINVTGTPEMYQTAVGWETFKDPNAVKNNVREYDGGPLKISSGYKDDNKERMAAKGVLDNSFYNAVLQKMALFPSDRVLGVNAVTKVREYMNNAGTWNNDFGSAMEKLSKLRATSDPSKIEIRNVCSKTN
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRKAEKQQATAPVSAFAARKARQQQAQLVEPEKTAQNEPAVEPPSKRARWSPEEGAARQAANGNDRVQTRRSTRRKAETLSSELAEKQPQRSAAAARAQIAERTPAPEKGDAETSDAAEEEEEDILERENGVGVIAAEDDAEGYESPADDVPQVQNFPLSKTRLNKSNIVFSDERTLCVRIKEKMTLVLLGHYDLWVKRGVISLMGAKLHPSPRLYRVYAPSTHSLPVIKCVAGVDGEAEIEVKSCNSGIYRLRHLSPLYQRIWNGKNTAADKLTLKKASASTKRTFSVLYTSSDDSWNRHLRPLHLEKQWSSAIRSLSQRGGRLKVLICGPKASGKSTFSRYLLNHLLSPAPQTENNHRNTDGVAFLDLDPGQPEFSPMGQVYLAHLRSPFFGPPFTHPSLAESQDGSIIRSHHIGVTSPKEDPDHYVLAAMDLMDRYRALLASYPQCPLIINYPGWIFGLGLEVATWLVKSLGLSDVVYMSEKGPAEVVEPLGHAAQEARVPLTTLPSQPTDFVSRSSAQLRSMQVQSYFHMSHPSEIHNPQWLDTTMSRSRPLVVDYAGPRQGIRGIMVMGSQISPDLLHEALDGALVGVVAVESPNAIMGQADTAGFSGSSQRDATQGAEDLSGAASDVDMNDVTDASHGDVAPTSSSSVESMITRTPNEDLPYLFVGSGSCNPLDPKASNCLGLALVRSIDVPSRKLELITPIPGSKLRDALEQGHGIVLVRGMLDNPSWAISEDYYAARAAEKHHQELVAKARKETDTRDGRDAAGDADTQGMVSALLRDRIRRASNVPWMTVIEDNSRRHREAAQREKSLWKLRKKAYPGSESETDW
The following text describes a protein:
Function:
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II. Can enhance DNA binding of the GAL4 protein activator.
Miscellaneous:
MISCELLANEOUS: Present with 18000 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Sequence:
MPIDQEKLAKLQKLSANNKVGGTRRKLNKKAGSSAGANKDDTKLQSQLAKLHAVTIDNVAEANFFKDDGKVMHFNKVGVQVAAQHNTSVFYGLPQEKNLQDLFPGIISQLGPEAIQALSQLAAQMEKHEAKAPADAEKKDEAIPELVEGQTFDADVE
The following text describes a protein:
Function:
Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol (1,2-PD) to propionaldehyde. Required for S.typhimurium growth on 1,2-PD as the sole carbon and energy source (Probable). This subunit is directly targeted to the BMC (By similarity); The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
Miscellaneous:
MISCELLANEOUS: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate. BMCs can constitute up to 10% of total cell protein.
Subcellular Localization:
Bacterial microcompartment. Note=Probably located inside the BMC shell.
Sequence:
MRSKRFEALAKRPVNQDGFVKEWIEEGFIAMESPNDPKPSIKIVNGAVTELDGKPVSEFDLIDHFIARYGINLNRAEEVMAMDSVKLANMLCDPNVKRSEIVPLTTAMTPAKIVEVVSHMNVVEMMMAMQKMRARRTPSQQAHVTNVKDNPVQIAADAAEGAWRGFDEQETTVAVARYAPFNAIALLVGSQVGRPGVLTQCSLEEATELKLGMLGHTCYAETISVYGTEPVFTDGDDTPWSKGFLASSYASRGLKMRFTSGSGSEVQMGYAEGKSMLYLEARCIYITKAAGVQGLQNGSVSCIGVPSAVPSGIRAVLAENLICSSLDLECASSNDQTFTHSDMRRTARLLMQFLPGTDFISSGYSAVPNYDNMFAGSNEDAEDFDDYNVIQRDLKVDGGLRPVREEDVIAIRNKAARALQAVFAGMGLPPITDEEVEAATYAHGSKDMPERNIVEDIKFAQEIINKNRNGLEVVKALAQGGFTDVAQDMLNIQKAKLTGDYLHTSAIIVGDGQVLSAVNDVNDYAGPATGYRLQGERWEEIKNIPGALDPNEID
The following text describes a protein:
Function:
Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L-Lys- bond on the terminal residue of Lpp.
Subcellular Localization:
Periplasm.
Sequence:
MMIKTRFSRWLTFFTFAAAVALALPAKANTWPLPPAGSRLVGENKFHVVENDGGSLEAIAKKYNVGFLALLQANPGVDPYVPRAGSVLTIPLQTLLPDAPREGIVINIAELRLYYYPPGKNSVTVYPIGIGQLGGDTLTPTMVTTVSDKRANPTWTPTANIRARYKAQGIELPAVVPAGLDNPMGHHAIRLAAYGGVYLLHGTNADFGIGMRVSSGCIRLRDDDIKTLFSQVTPGTKVNIINTPIKVSAEPNGARLVEVHQPLSEKIDDDPQLLPITLNSAMQSFKDAAQTDAEVMQHVMDVRSGMPVDVRRHQVSPQTL
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MFAAESGYCPEAAAAFWTEPAVMANIMDPDIMDSLFDMPEYEEEEDDFPPLPPPLPPLSPSREDGEEGGQGDPTANGEDADDIGGKMLAAMEDVPMAGKKSRRKPQPKLDAKRLCGERGIPSLPKHFDKVKFAGKGHEKEDLKLLMRTMEHWAHRLFPKLTFDDVIEKVEQLGQKKPVQVCMEKLRMGMPLLDEDFVRRGDDEDQADEAGAGAGAGAGAGAGAGSDQDTDSGAQPASQPGPSQPTGLTAEQREKMEHNRRLAEERRKARLQALQQGQEDAVPGPSSAPDHDSSTMDTSLTSEEDLSSNKVPDDLDQDIQKPAENMKQDGSDTSPITPASSQPAPGETSEEAILHVSHNAPDTNGAPEPDDSNEGSGSGLEGKLKCQSKPSDENLQTVVENNTDEQEPVQANGSKEQACSHDENV
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Membrane.
Sequence:
MSESSTLRSFDAFPKVNTAYKRQSTRGGLATLVIGVLCFYFLCSELRGYSNGHEEHIYTVTKDLAETIQLNVDVTVAMPCKSIKVIAQDYSEDTFFAHELLNMQGLTYDFGTDRMQHEIHSHKAYEMNSKTLKKSKFKHTRVGSHSTDPHCRISGSVPINHVEGALQIFNLPDNQYFINPMKASDGLNLTHAIHELSFGDYFPKVLNPLDGVSTVTDEPLMSYQYFLSAVPVEYSSGRKKIHTYQYAVKKQTTNLQEHFVTRPAIFFHYKYEPVTLKIQDSRETLTVFVVKLLSILGGFVVCGSWIVRGGEKAYEKIVGKKLNYASLHTGGLLDRKS
The following text describes a protein:
Function:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MYFIYQLPPPISLILIISFISTSVYINLRLTRFVLKTYAGLLQRRNLKNRAKLLSLIGIKDEGTATKKVIIGFLHPYCNAGGGGERVLWTAVALHQRTEPDTICAIYTGDLEVSKQEIIHKVKSRFGIILDPSSLLLVPLKTRYLVEASTWPRCTLLGQSLGSLVLGYEALSALIPDIYIDTMGYAFTFPVFRLLTDVPIGAYVHYPTISNDMLQRVSRRNSAHNNSSTISNSVVLSYAKLIYYIIFAELYSFCLRQAHHLMVNSSWTKNHIDRLLQPWLYRDEVESEETPQDWTTSSDPSQSKSLKPGGLRLRIPSTKDERNDTTNIPKRKSRKFVRSTVVYPPCDVESFLDFPISPRKLTILSISQFRPEKDQGTQIKAFARFLSTLESDDPRRTEIKLVLAGSCRDHADHERVAQLKELAHQLGVSQTVLFLVNVSWDQLKNLLKESLVGISTMIDEHFGISIVEFMASGMIPLVHRSAGPLLDIVVPLGHHHQGSEERRTGFHADGEAEYAAHLAHIFCSLSPDERIQIQSDARLLARTKFGVGQFERLWINSFRQIVAKNQPD
The following text describes a protein:
Function:
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation.
Sequence:
SQLMASDMDYERPNVETIKCVVVGDNAVGKTRLICARACNATLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYPEIKHFCPRAPVILVGCQLDLRYADLEAVNRARRPLARPIKPNEILPPEKGREVAKELGIPYYETSVVAQFGIKDVFDNAIRAALISRRHLQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSSEERPAHLLEDPLCADVILVLQERVRIFAHKIYLSTSSSKFYDLFLMDLSEEELGGSGAGGSLPGEEPRGHHHHHHHHHHHGRDFLLRAASFDVCESVDEGGPGPAALRASTSDGILRGDGAGYLPGRGRVLSSWSRAFVSIQEELADDPLTYKSRLMVVVKMDGSIQPGPFRAVLKYLYTGELDENERDLMHIAHIAELLEVFDLRMMVANILNHEAFMNQEITKAFHVRRTNRVRECLAKGTFSDVTFVLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTREVAFPHTSKSCMRAVLEYLYTGMFSSSPDLDDMKLIILANRLCLPHLVALTEQYTVTGLMEATQMMVDIDGDVLVFLELAQFHCAYQLADWCLHHICTNYNNVCRKFPRDMKAMSAENQEYFEKHRWPPVWYLKEEDHYQRARKEREKEDYLHQKRQPKRRWLFWNGPSSPSSSAASSSSQSSSSAVV
The following text describes a protein:
Function:
ATPase that stimulates 40S and 60S ribosome biogenesis. Also involved in ribosome-associated quality control (RQC) pathway, a pathway that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation: localizes to the ribosomal E-site and stimulates VMS1-dependent tRNA cleavage.
Miscellaneous:
MISCELLANEOUS: Present with 17600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
Sequence:
MPPVSASKAKRDAKKAEREAKKAAAGKTIRKLGRKKEAAAEESEVDAAAREIKMMKLQQDKDGLSDRVVTGVLSSLETSRDIKLSSVSLLFHGKVLIQDSGLELNYGRRYGLLGENGCGKSTFLKALATREYPIPEHIDIYLLDEPAEPSELSALDYVVTEAQHELKRIEDLVEKTILEDGPESELLEPLYERMDSLDPDTFESRAAIILIGLGFNKKTILKKTKDMSGGWKMRVALAKALFVKPTLLLLDDPTAHLDLEACVWLEEYLKRFDRTLVLVSHSQDFLNGVCTNMIDMRAQKLTAYGGNYDSYHKTRSELETNQMKQYNKQQEEIQHIKKFIASAGTYANLVKQAKSRQKILDKMEADGLVQPVVPDKVFSFRFPQVERLPPPVLAFDDISFHYESNPSENLYEHLNFGVDMDSRIALVGPNGVGKSTLLKIMTGELTPQSGRVSRHTHVKLGVYSQHSQDQLDLTKSALEFVRDKYSNISQDFQFWRGQLGRYGLTGEGQTVQMATLSEGQRSRVVFALLALEQPNVLLLDEPTNGLDIPTIDSLADAINEFNGGVVVVSHDFRLLDKIAQDIFVVENKTATRWDGSILQYKNKLAKNVVL
The following text describes a protein:
Function:
Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to DMSO (By similarity).
Miscellaneous:
MISCELLANEOUS: The Tat signal sequence is essential for the expression of dmsA, the stability of the dmsAB dimer and membrane targeting. Despite the presence of a signal sequence, dmsA is not exported to the periplasm (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSNFNQISRRDFVKASSAGAALAVSNLTLPFNVMAKETQRLNENNQERIVWSACTVNCGSRCPLRMHVKDNRITYVETDNTGTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRIGKRGEGKFKRISWDEALTEIADALKRNIKKYGNESIYLNYGTGTLGGTMAKSWPPASTMIARFMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGMADIENTKLIVLFGNNPAETRMSGGGLTYCIEQAKARSNAKMIIIDPRYNDTGAGREDEWIPIRPGTDAALVAALAYVMIQENLVDQPFLDKYCVGYDEKTLPTDAPKNGHYKAYILGYGNDGIAKTPEWAAKITGIPAERIIKLAREIGSTKPAFISQGWGPQRRSNGELISRAIAMLPILTGNVGIHGGNTGARESAYSIPFVRMPTLKNPVKASIPMFLWTDAIIRGTEMTALTDGIRGVDKLSSPIKVIWNYASNCLINQHAQINRTHDILQDDTQCEMIITIDNHMTSTAKYSDILLPDCTTSEQMDFALDAFVSNMAYVIFADQVIKPSFECRPIYDMLSDLAEKMGVKEKFTEGRTQEEWLRHIYEQSREKLPELPTFEEFRQQGIFKKVDPNGFKVAYKDFRDNPEAHPLKTPSGKIEIYSSRLAEIAKTWKLAEDDVIHPLPIHAQSFEHYGDPLMEKYPLQLSGFHYKARTHSTYGNVDVLKAANPQEVWMNPIDAEPRNIKNGDMIRIFNDRGEVHINVKITPRIIPGVVALSEGAWYAPDKDRIDHSGCINVLTTQRPSPLAKGNPQHSNLVQVERL