lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes. Following recruitment to lesion-stalled RNA polymerase II (Pol II), the CSA complex mediates ubiquitination of Pol II subunit POLR2A/RPB1 at 'Lys-1268', a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment. The CSA complex also promotes the ubiquitination and subsequent proteasomal degradation of ERCC6/CSB in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. Also plays a role in DNA double-strand breaks (DSSBs) repair by non-homologous end joining (NHEJ).
Subcellular Localization:
Nucleus. Chromosome. Nucleus matrix. Note=Recruited to lesion-stalled RNA polymerase II (Pol II) sites by ERCC6/CSB. UV-induced translocation to the nuclear matrix is dependent on ERCC6/CSB.
Sequence:
MLGFLSARQAGLEDPLRLRRAESTRRVLGLELNKDRDVERIHCSGVNTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQPYYTCKAVCSVGRSHPDVHKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQIADVFNFEETVYSHHMSPVATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYEYILATASADSRAKLWDVRRASGCLITLDQHNGKKSQAAESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVYNDSRKGLKFTVSSGCSSEFVFVPYGSTIAVYTIYSGEQITMLKGHYKSVDCCVFQSNFQELYSGSRDCNILAWVPSLCESVPDDDDETSTRSQLNPAFEDAWSSSDEEG
The following text describes a protein:
Function:
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Subcellular Localization:
Cell projection, cilium membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Sequence:
MLLPVFTLKLRHKISPRMVAVGRYDGTHPCLAAATQAGKVFIHNPHTRSQHFSASRVFQSPLESDVSLLNINQAVSCLTAGVLNPELGYDTLLVGTQTNLLAYDVYNNSDLFYREVADGANAIVLGTLGDISSPLAIIGGNCALQGFDHEGNDLFWTVTGDNVHSLALCDFDSDGKKELLVGSEDFDIRVFKEDEIVAEMTETEVITSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNHAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTPEMRGNIMDTSVEQDLIRELSQKKQNLLLELRNYEDNAKAELSSPLSEADGHRGVIPANTKLHTALSVNLGSAAQAAHTELCISTSNDTIIRAVLIFAEGIFLGESHVVHPSIHNLSSSIRIPITPPKDVPVDLHLKTFVGYRSSTQFHVFELTRQLPRFSMYALTSPDSASEPPSYVNFIIAERAQRVVMWLNQNFLLPEDTNIQNAPFQVCFTSLRNGDQLFIKIKLSGEITINTDDIDLAGDIIQSMASFFGIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADNSNLIRSLLVRAEDARLMRDMKTMKSRYMELYDLNKDLLNGYKIRCNNHTELLGSLKAVNQAIQRAGRLRVGKPKNQVISACRDAIRSNNINTLSESCGWGQLLRRRGENR
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSQSESEDGHTDSDLVKFKDSGGGENLPFGFLGKRGRMKGSQKKASEIEGCYRAEWRPVPNGGRGILSTSQGKGHCSFSLSLSLSLSSIYLTLYNWTILFGWLKVLYLAVQTLRESGHEHVYDAIQLLLQLTQTSALLEIIHGLVGLVTFPISVTLSQIGCRLYLTWGILWSFPQTQSHILVTSLVISWSITEFEVTSWLLKIIWYSFFGMKEALGFAPSWHLWINFLVVDPSGGRYPNSTSSEPFEEKIALGLMAAKTCF
The following text describes a protein:
Function:
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity). Required for the development of the one-cell zygote and endosperm in embryos. Required for micropylar pollen tube guidance, but has no effect on ovule development and gametophytic cell fate specification. May regulate the transcription of secreted cysteine-rich peptide (CRP) genes in the embryo sac.
Miscellaneous:
MISCELLANEOUS: Expression of MEE12 in the central cell alone is sufficient to restore the normal pollen tube guidance phenotype.
Subcellular Localization:
Nucleus, nucleolus. Nucleus.
Domain:
Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds.
Sequence:
MICTECENDAFDEEDDGYYYCQRCGVQVENLIQTGVDDGDLIGEGGGTQGALYNPKHRRTEPQPITPSQPRFTDDTSRYSQFKSQFESENGNKELPREVKRAPDSYVDKEPTEPVDFAAETLSYENYYDEARDRYVKAFLMMITYQCDALVDKFNVTPLIIGLVGPISLRYVALSGVYHKDWANNAIRDSEHQSEDGEVKDAKRLKRHKAEPRNIDGKRAVTIWFGILKKTMPLSSSLVISFLACHQAGAPVLPTDIVRWAREGKLPYLSCFLDIREQMGERSAACPVKVSIMARPFQVISAQMLEARASVIADTIGLPLPPVNFYGIASNYIKQLSIPEDKILDLARLIQNWSLPPELYLSTNEQKLPSRVCVMSILIVAIRMLYNINGLGVWERSLGFVNASDGDSETNSGTAEKATEFDTQELLKNLEAKYHEVAAETLESEKDLVSYLSLGKNEFFAGLEEDSPDDTYRIVDNLWNGYPKDEDIECLPKRGRDWDDDVSLNQLSLYDSRFSDGNNPCSSSSRRNESVSIGLDLSSSEHRESSSPEKLKEIAIKRLITDMGDDLFCYIPPRVKVKRLDYLQYVRKKEDGALIYAAHADYYILLRVCAKVAEIDVRNMHRGVLSFERRLAWIEKRIDQVLHLTRPLMTCKHCCDDGNIGEDQDD
The following text describes a protein:
Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSDKPDLSEVETFDKSKLKKTNTEVKNTLPSNETIQQEKEHNERT
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MDNAEVSTVEHQTDIYQDAVVFITGATGFVGKSLLEKLLWSFPQIKRIYMLIRPKGGVTVEERFRGFLQNPIFERIKSEHPTQLKKIFHFSGNIEDDNLGLNESDRSVLCAEVNIIFHSAATVRFNECLKVSARVNSQATYNLLELCRQMPYLRSFLYVSTAYCNPGRKYVDEQVYPTMPPVDWRQFLSATQKIPDDYLNRLADYIKGPHVNTYTFTKSIAEQIVNAYKDVIPIVIVRPSIVTAAYREPYPGWIDNIQAISGIMMEIGKGGISSILGNKDLICDIIPVDFVVNAMIMMVGKAKLGSLSICNATSGVTNPITWQHLGELTMKWSRIYPTRRMIMFPNFKYRCSAFNHELAVWVLHFVPALLMDLQTLLLAQKKRLVTPIAKKFRQACLAGSFFSLNEWIFKNKSRFYFKEMIENGTYPTLYWNLEEMDYDEYVRRHMIGINKYLHREKFTVDSNKFMVTRIYWFWIFLHLMFYMMLVYISF
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
Sequence:
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
The following text describes a protein:
Function:
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.
Subcellular Localization:
Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction. Note=Colocalizes with beta 2-syntrophin and utrophin at neuromuscular junctions.
Sequence:
MVTGLSPLLFRKLSNPDIFAPTGKVKLQRQLSQDDCKLRRGSLASSLSGKQLLPLSSSVHSSVGQVTWQSTGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTENVPDEEGRRSPRMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERPSLTFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLEKLLQDAHERSESSDVAFVIQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGHGIKCDIPRYIVSQLGLTRDPLEEMAQLSSYDSPDTPETDDSVEGRGVSQPSQKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTSSAYEVKQHPFFMGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHVDSEDEEEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRHRCSGLPDGPHCPEETSSTPRKQQQEGIWVLIPPSGEGSSRPVPERPLERQLKLDEEPPGQSSRCCPALETRGRGTPQLAEEATAKAISDLAVRRARHRLLSGDSIEKRTTRPVNKVIKSASATALSLLIPSEHHACSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSLRPPIIIHRAGKKYGFTLRAIRVYMGDTDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELVLKSGNKVSISTTPLENTSIKVGPARKGSYKAKMARRSKRSKGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPPQGYRVAPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPATAASPQRSPSPLSGHGSQSFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAAAEKKLAPSRKHSLDLPHGELKKELTPREASPLEVVGTRSVLSGKGPLPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTDEEPENSQATQEPRLSPHPEASHNLLPKGSGEGTEEDTFLHRDLKKQGPVLSGLVTGATLGSPRVDVPGLSPRKVSRPQAFEEATNPLQVPSLSRSGPTSPTPSEGCWKAQHLHTQALTALCPSFSELTPTGCSAATSTSGKPGTWSWKFLIEGPDRASTNKTITRKGEPANSQDTNTTVPNLLKNLSPEEEKPQPPSVPGLTHPLLEVPSQNWPWESECEQMEKEEPSLSITEVPDSSGDRRQDIPCRAHPLSPETRPSLLWKSQELGGQQDHQDLALTSDELLKQT
The following text describes a protein:
Function:
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Subcellular Localization:
Nucleus.
Sequence:
MSTVLFSSIGGERLASRKSVPQEIAPLLKRTGTCRNLFGPVDHDELRRELASKLREISERDQQRWNFNFSEGQPLDGDLKWEESPAEGCPLFYRETAPITMKKRQIVDLPTTQRTINVDRKCESPMKFCKSQTQRRKSRKRVQTKSQTNMRITDFYGKRKRTDVCKERRSMD
The following text describes a protein:
Function:
Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations.
Subcellular Localization:
Cytoplasm. Cell tip.
Sequence:
MSVRKRYKVTYVLDSCNDQLGHRLDANCLVLGRYFSEQGSAPVTRALYSGGRDGQLFGWDIGYDYGKASQPLAKIQAHSAWVNDIALTHDSEGVISCSSDSTVKLWKPHVLNASCLSTIGEHTDYVKRVSIPKYSKSPLVASGGLDKRIIVWDYNVGQEVMRFEQLPDCSLVVGPRSGVYSLAANNNIIANGGLQKDIQLWDCVSKKRITDLVGHTDNVRDILISDDGRTILTASSDATIKLWSLRAQKCLFSFIAHSDSVWALYSEHPDLKVFYAGDRSGLITRTDIRNQPNNQSCTAICKQDAPVSDIVARQSFIWSTSRDGSILRWKDEPLFNQDVGAALSKHTSSHLSVSSDCPSRHSSDIRNHSCPTLYHDDAEDIYYDLHHTESYSNINLTKTPDYVIHGGIGLLKYRMLGDRRHVLTEDAVGNKCLWDILACKQAGEFDKSEDFEKIVQSLDTVQAIPRWASVNCLLGILAVTLDENHYMDAEIYADECPLLKVDSPSDKRINLGVWILKNLFREFIDAELHRDLKFRQNLDVVRSEAKKQIEAQREEARKGNVNMPSALSPLRIRSRPSPLSLPPEPLLSPTIDYSATPFPLEPPPESPGPSLQIPSNNPVYTNLTDTDSMMGAPDYFSIPARQNRNRKPHTEVVGSPTVVRTKEIIPPKVTREGSFMGRLKKLGRSKSSKSLQTDFMKASVERAASSRVFSTGTSVTSPQALSKTNNTVNNAANTENNTLAKDKQQTSEASSPGTPRELKTTGELIEDLHEQYVHFKDKDTVLSLMKPPNDDTFPMLNLSSQITVIISEESPEAGNSRDIYRSTLENMADDIDLLENIMPFWLGRLLLLNEFPSKTAPTVNFTLQPFPGSGLPLIVNENTRLSASAMLRAQKIMDYSYSKLSQQRKDVSSLQFRCKDVVVTPKMTLATVKARIWRSGDDVVFHYDVAPRSVSEIVDKTQSLNI
The following text describes a protein:
Function:
Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Major isoform.
Subcellular Localization:
Nucleus.
Sequence:
MSALLQDPMIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPSKLFGARGNPALSDPGTPDQHQASQTHPPFPVGPQPLLTAQQLASAVAGVMPGGPPALNQPILIPFNMAGQLGGQQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNSQLQQLQLQLQQQQQQQQQQPPPSTNQHPQPAPQAPSQSQQQPLQPTPPQQPPPASQQPPAPTSQLQQAPQPQQHQPHSHSQNQNQPSPTQQSSSPPQKPSQSPGHGLPSPLTPPNPLQLVNNPLASQAAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSVGQAASQGNLLHLAHSQASMSQSPVRQASSSSSSSSSSSALSVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQHEPATAVPLEPLTDSLEENS
The following text describes a protein:
Function:
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
Sequence:
MLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH
The following text describes a protein:
Function:
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAPFKTLVEDYPRYLKSFELFLERSSEHQCMQDFIHNTLPDILASIGGGRSVFNVMGVGSGAGDIDLEMLAQLHLKHPHVKVDNEVVEPSNDMLYKYKARVSTSPDLAYINFTWNKMTASEFEKQWQEKTPEKKMDFIHMIQMLYYVKDPNATVSFFRSLLEKDGKLLIILVSGESGWGKLWTTFRKQLCYTEMSQCVTIGEIKSFLDSEGVPYRKYVLLSQMDITECFTEGDQEGELLLDFLTEVKEFSKNAPERLKKEVLDVLRHPDCSKEVDGRIIFNNNLEVLVIEP
The following text describes a protein:
Function:
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.
Subcellular Localization:
Nucleus.
Sequence:
MTSNNQLAFACVCASNVNRSMEGHRVLKEAGFNVSSYGTNDYVKMPGASNVPLQFDFGATYKEILSKMESENNQYYEEQGLIKMLRDDANTKEKPERWSSTFNPATLKYFDVIFTYDNNVMDRVLNEFRENGNRTFQISHVVNIQTPDSRDNAILSRQYTLRLAQMLSAATDLTENLESIVDQFNMENGNPKDSFVASFHIVSY
The following text describes a protein:
Function:
May act as a co-chaperone for HSP90AB1. Promotes Sendai virus (SeV)-induced host cell innate immune responses.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear in the G1 and S phases of cell cycle and is evenly distributed between the nucleus and cytoplasm in the G2 phase (By similarity). MSL1 can promote its nuclear localization (By similarity).
Sequence:
MEQPGQDPTSDDVMDSFLEKFQSQPYRGGFHEDQWEKEFEKVPLFMSRAPSEIDPRENPDLACLQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSEAACEDEDSASEGLGELFLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLRGRKVYQIR
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Miscellaneous:
MISCELLANEOUS: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MKINNSLLNFVNGMLVTLPSSKTLTLSWNFGSMLGMVLVFQIVTGTFLAFYYTPDSLMAFSTVQYIMYEVNFGWIFRIFHFNGASLFFIFLYLHIFKGLFFMSYRLKKVWMSGLTIYLLVMMEAFMGYVLVWAQMSFWAAVVITSLLSVIPIWGPTIVTWIWSGFGVTGATLKFFFVLHFLLPWAILFIVLGHLIFLHSTGSTSSLYCHGDYDKVCFSPEYIGKDAYNIVVWLVFIVLSLIYPFNLGDAEMFIEADPMMSPVHIVPEWYFLFAYAILRAIPNKVLGVIALLMSIVTFYFFALVNNYTSCLTKLNKFLVFLFIISSVILSWLGQCMVEDPFTVLSPLFSVIYFGLAYLLLGIFMTSKLLFK
The following text describes a protein:
Function:
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
Sequence:
MSRGKFPRGGGSDVIEIDNLRCRTEIGISQHEIGKKQEVVISIRLGCDVGKAGKSDDVRDSVNYSDVSKDVINYAESTSFNLVEKLATDVARICIALYKVPWVQVRVHKPKAVRFSDSVGVLIERTSEDFSDSVVYLSLGSNIEPRKNLRDAIAFLKTKALVLKVSSSFLTPPQLQTNQPDIVNMAAQILTEMTPTQLKTFISEIEEELLRVRDPNNKHGPRTVDLDISLWGSEVLEYSIAGTEEGTNHSPPNGNKKKKVPDPDVLRFAHVAVPLAEISPHLKHPTNGSTLASIARDITGREDYINTFPIVDLFR
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSKRSGSYVIEVFEFTGGTNRVKSEQPQERRLSQSWEMTRIEEHQESGPGRSASVGSTRASSPGEQGTIDTPSTYDSDGQVEEDRPPPPAYITLPVSPLKRRLVILDMNGLLCHINHNKWFRTNNVVPHGKLGAHKSWVARPHLCEFLREVTQVVDLAIWTSRTESNLARLLQQMSAYLPENFSETIWQLLDQSYCYPLPQADANYPLWLKPLNIIEEMSDHKVANCLLVDDSPLKNAMNHPHNAIHPPTFSPLKQDDDYLSTYLLPFLKKFARSPQPVTHFVRSNWPESSDVFRLLANYWGKNLPSILFSQVRDQAEVEKLRQQVLAEGDMAAAAAAEL
The following text describes a protein:
Function:
Plays a fundamental role in microtubule organizing center structure and function. Component of the infraciliary lattice (ICL) and the ciliary basal bodies.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MKNQQQQSSGNTNAAQIRKKLLNNQQVLSESQKNEIKKAFDYFDTAGSGTIEATNLKVVLRALGFDPTQEEIGKLIKDLGKGDVKYDAQRIDFQEFLEIMMVKMSQKDSLDDIKRAFNLFKDGNNPKKMITFDSLKKVIQDLDEDMTDQQILQLLKGAQSNTNELKEMDKDGKEEKKQPEDEYKIEVSEDQFIKILTRDLNDDKEKL
The following text describes a protein:
Function:
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity).
Subcellular Localization:
Secreted.
Domain:
The mature protein is largely unstructured in the absence of a cognate ligand.
Sequence:
GTATCETQRLANFLAPSSNKLGAIFSPTKMGS
The following text describes a protein:
Function:
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.
Subcellular Localization:
Nucleus.
Sequence:
MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNESYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLRQHRLSEEERQRQEQEEDERETAALVEESRKRRLLEDSDSEEDTSPTQPQPALRPNPTAILDETPKAKRKAESWERSVGTLGSRPQLSGLVVKKTGLDTSIRRGRAPPLPGVMKNGQVAGPAPQMPGTSSLSQLGVYSDSEDSSGSN
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent oxidative decarboxylation of homoisocitrate to 2-oxoadipate (alpha-ketoadipate), and of isocitrate to 2-oxoglutarate, at near equal efficiency. May thus play a dual role in glutamate and lysine biosynthesis in vivo. Preferentially uses NAD over NADP.
Sequence:
MYKVAVIKGDGIGPEVIDAAIRVVKSVTDKIKFYEFEGGLSVFKKYGVPIREEDLEEIRKMDAILFGATTTPFDVPRYKSLIITLRKELDLYANLRIIPNFKLRKEIIIVRENSEGLYSGEGAYDSNKVVDFRIITRKGAERIAKFAVKLAKDRSTFLTFVHKANILESDRFFRKIVLDIARKEDVKVREEIVDSFTIKLVKDPWNLGIILSENMFGDILSDLATIHAGSIGIVPSGNYGEDIALFEPIHGSAPDIAGKGIANPIGAILSAAMMLDYLGLDGSIIWKAVGRYVRRGNLTPDMEGRATTLEVTNGIISEIYRLDEYEIDEVWRDEVRLGRILLEIS
The following text describes a protein:
Function:
Involved in reproduction of the worm. Involved in host-parasite interaction. Delivered into the host cell by means of parasite exosomes. Binds to acidic phospholipid membranes in a calcium-dependent manner in vitro (By similarity). Causes aggregation of liposomes in the presence of calcium, but not in its absence (By similarity). Likely to promote membrane fusion (By similarity). May provide structural integrity within the tegument (By similarity).
Subcellular Localization:
Tegument. Secreted, extracellular exosome. Host cell. Note=Mainly locates on the cytoplasmic face of the dual membrane of the tegument. Associates with the apical plasma membrane and its derivatives including surface invaginations. Localizes to vesicular structures, such as the elongate bodies, and to muscle layer, within the tegument.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
MGRSKLQIIGPNGEIYQPTLKIQRNNDPNKDAEVLYEAMKGWGTNEDRIIGILGYRSSHQRIIIRDQFKALYGKDLITELSSETSGHFKKLLKMLLTDTDKMNARALYKAMKGGGTDESTIIEVLCTSSNCEIEDIKTAYQSVLKDYGISDPRRTLESDVEDDLSGPFKNLVIALLQAKREEIPFEIAEQIQSKGIKSVVDMNLVEQDVETLWDAGEARLGTDEAAIIKILVSRSVWHIQAIAQHFEKKYGKSLIDSLASETSGDFESALLLTLNTCLNRPKAYADLLLKAMKGLGTDDCTLMRIIVSRCELDLGSICQEFERSQGSSLEEWIRSETSGDYRKLLLALIGAEWS
The following text describes a protein:
Function:
Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMGEFKHPPQEKQKMSSTKKAGYSNPAFAAMGIPALRLPGPKWCAFWLVVGAGIAGVVYDKREQRRICKHYSSLVKDQGAAHMDTWLKPRRLTVFVAPPPGDYLETSMKVWRRYVKQVLFEAGLDYEVFTEERQGVIRHEVAERVRQLRRDIAAAEAAEQRALDEKRWLNRMRSWWRREKLSEEELERIRAQKFRDEFTYKQLLGVFYKNAPLREQKVWDADALVEDPVLAGGVICIGRGAYKEYIAGIHEGTLGPLDPPTLTPEAPTELSAAAEDLTQAPEQPEPSAAAEALKQAPEQAEHSPAEPDSAATDAPDEKSNNAPAPPPAPYVSPDEYSSLSLSQELVGDVRHPSSHIPALFHQPLLVIPVPNLSGFLQTPRKIYRFYTRRYYAEECCKAAAAMVLQTIRPFQPDDLNLGISEEEDWPRRWVEQGRERKSEWVQDLKADPRVIAELHVVDPALMADLAATMNLN
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGQAGKVFGKQITYSVSPFQQKLFVNYFKNAMPHLRRGVRDNFWASVPYMAALYITVNWANETYHNEAKDHWY
The following text describes a protein:
Function:
Catalyzes the formation of pyruvate in the last step of glycolysis, it is irreversible under physiological conditions. The reaction is critical for the control of metabolic flux in the second part of glycolysis.
Sequence:
MSRRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIKTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSQDAMDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVHFDSANDGVAAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTVE
The following text describes a protein:
Function:
Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro.
Sequence:
MSATDASTADSGAKRKSSEDITHNCNANFGAENGLRKRVKSEEPVASIKDETNPEVPMKIKAEPVENADEPTSTTPAIKIKAEPADNGNSPAAAMVKTEPTNSNAQDAADESTVSSSSIRTSCRFGIRCYRRNPAHRSAEAHPGDQDYRRPNFPAPPLGTPACPFGNACYRRNPVHFQDYSHPADFNSAQNIRNRLRQRRAQRQNDDDSGTDEEDEPFGGDNDRDADYRPGADINEDEDDELEFDSQPISGDDYD