lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence:
MAPKAEKKPAAKKPAEEEPAAPAEKAPAGKKPKAEKRLPAGKSAGKEGGVDKKGRKKAKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAGELAKHAVSEGTKAVTKFTSS
The following text describes a protein:
Function:
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrium between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
Subcellular Localization:
Mitochondrion.
Sequence:
MAIWRIINRSYLKYASNQLTRNYYTQVCLASSTHVVKQTTKLSSFDIPNSDICTRPSNIFQNLRFLATSAQTRKKEAEVDSDGPRLNEKITGDYVRLVSEEGHCVVSLREALRRAKELQCDLVEVQRDAKPPVCKIVKYSLELYKKAKVGKERAKAKRAEAIRPDIKEIRFTPKIEAKDLKFKSDQALKLMESGYRVKCLAVPDKDKHKELEPEKLLELLFRFTCFIGDALVESWPEADRKGAVVIVRHAKFGPPKKGGVKLMKDIDIKSARVKEESPKPDSSKAGVATVDDQEDIEKSEPRFSVEQAQPVKFQNAYAKREPSSEFSGGRDASRFEPQSPNQHVNPQRPRFSNQAPNQQPTGRFDPQSPNQPPSAPRPQFPNQQPTGRFDPQFPSQPPRPQFPNQAPNQQSTGRFNPQFPNQRPSPPQSRFPDQAPNQQPSGPSPNRHPDRQGPPPRFQNQAPNQQPTGRFEPQPPNPPRAPPRPQTRLPNETSNEQPTAPGRSSGPASGYGIFSTPKTK
The following text describes a protein:
Function:
Chloroplast chaperone required for RuBisCo biogenesis and translational regulation of the RuBisCo large subunit (RbcL). Stabilizes an end-state assembly intermediate of eight RbcL subunits until the small subunits (RBCSs) become available to produce a complete stable RuBisCo complex containing eight small and eight large subunits (By similarity).
Subcellular Localization:
Plastid, chloroplast stroma. Note=Associates with chloroplastic polysomes.
Sequence:
MNSAALNARTASVAPQPQACHACKCRQLLSRRVPPAQRQVECSAIAPETLQDIIVGGAVVGAVSVALYAGLKKDPVPCSLCQGTGGIRCFACGGDGRNATVSRDDLYDSKALGGGVAPPKRDPLGRTINPRDCKVCRGAGLVLCSQCKGTGFQSAF
The following text describes a protein:
Function:
Nuclear genome-encoded factor that participates in photosystem I (PSI) biogenesis. Cooperates with the plastid genome-encoded protein PSI assembly Ycf3 in the assembly of stable PSI units in the thylakoid membrane. Involved in light-induced chloroplast development and growth. Involved in the plant response to abiotic and photooxidative stresses. May be involved in the suppression of photooxidative damage.
Miscellaneous:
MISCELLANEOUS: Plants silencing Y3IP1 can grow autotrophically on soil, but show a light-green phenotype, very slow growth and delayed development. Plants over-expressing Y3IP1 show enhanced resistance to salt, drought and heat stresses, and treatment with paraquat.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MTTQIFQLPLKYCASSFSSTGQRNYGASSSPSPIVICKSNGISDGLWVKRRKNNRRFGSLIVKQEKGDVTEIRVPVPLTLEQQEKEKQNRDDEEDEIDEGDVDPEDLKYVNEIKRVIELLRRNRDMIFSEVKLTIMIEDPRELERRRLLGIEDADTPSRDDLAEALEQVNDGKIPKDRATLRMLHEEMIRWPNLEVEVSKKQRGKSMYAKSTDTGIDPKEAAKRLNVEWDSAAAIEEVDVDDEQGVVTKVAGYGALYFVSALPVIIGISVVLILFYNSLQ
The following text describes a protein:
Function:
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MDKLSRSRSRACLVCGIILPYNTFAAKGCPNDGLDDVETYTSPVFEGVMAMVAPTESWVARWQRIDAFTPGMYATRVQGSLSDEMIDSLRQRGIHYRPRNGSSLD
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEEHQLVIEQLENMKNLKQLFHKMKNGNIRIVDAFSIVIYKLIRQFRPSSSEYLVLLQELFYLSIDMQLIHTSDQVLKVLLKQFPTSEKVQRLKGYLLEANGEDENALVVYEKMLSENLMDQNTRKRKVALQRRQNNVDQAIALLNTFLTSFPNDAEAWLELADIYQEHLNYSRAQFCLEEVLLLNSQDLHLAIKLAEVNYSNQNYTQAKNYYCFVLSKNPNEPRCLWGLLQTIRKKKREGNDKDLGTIVIQALQKIYKQQPIKYPFEKVALEIQQ
The following text describes a protein:
Function:
Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAAAGDGGGEGGAGLGSAAGPGPGPGPGLRGQGPSAEAHEGAPDPAPAALPPEEVAARLQRMRRELSNRRKILVKNLPQDSNCQEVHDLLKDYDLKYCYVDRNKRTAFVTLLNGEQAQNAIQMFHQYSFRGKDLIVQLQPTDALLCITNLPISFTLEEFEELVRAYGNIERCFLVYSEVTGHSKGYGFVEYMKKDFAAKARLELLGKQLGASALFAQWMDVNLLASELIHSKCLCIDKLPSDYRDSEELLHIFSSVHKPVFCQLAQDEGNYVGGFAVVEYSTAEHAEEVQQAADGMTIKGSKVQVSFCAPGAPGRSTLAALIAAQRVMHSNQKGLLPEPNPVQIMKSLNNPAMLQVLLQPQLCGRAVKPAVLGTPHSLPHLMNPSISPAFLHLNKAHQNLSHIPLAQQQLMKFENIHTNNKPGLLGEPPAVVFQTALGIGSVLPLKKELGHHHGEAHKTSSLIPTQTTITAGMGMLPFFPNQHIAGHAGPGHSNTQEKQPATVGMAEGNFSGSQPYLQSFPNLAAGSLLAGHHKQQQSQPKGTEISSGAASKNQTSLLGEPPKEIRLSKNPYLNLASVLPSVCLSSPASKTTLHKTGIASSILDAISQGNESQHTLEKCIAYSPPFGDYAQVSSLRNEKRGSSYLISAPEGGSVECVDQHSQGTGAYYMETYLKKKRVY
The following text describes a protein:
Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAPIKIPHQQVRQGFLWCLAAIYMFAFTSLYVQIPGLYGDRGLLPARYILHDHTSLSSVFRRTPTLLWLTPLLGLNTSSGMELLSLVGTVLSMVLLVSQRCRDCIAFLLLWFLYYSMVQVGQIFIWYQWDGLLWETGFLAILIAPWNIGPARSEKQRCFYCKRDRNTARHHDAVSLWLVKWLLFRLMFASGVVKLYFMDTTWWELTAMYWHYESQCIPTPVAWYFHKLPKWFHRLSVVITYVIEMGLPFLFFVPVRVIRIFAYFGQVFLQLLILITGNYNFFNLLTMTLCISLLDDVFITTPITTMAGRIKTASIAASFLATMVTIGILINRWFWFETTNGGLYSWIAFSPADFRYAVNIATLAAIWVGLISLMLEIVSALLRCFLEGGERLKQTCSLVQCVAVSLVALLLFAVSLEPFTDISPRTKSKLPSSFRGWYKQTKYLEVAHPYGLFRSMTGVGGRPEIIILGSNSTEGPWEEYDFLYKPGNIYAPPPFVAPHQPRLDWQMWFAALESYESNP
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.
Sequence:
MANKGMDRSFMTASVEDLVQRMSLTEKVSLLSGEDWWRTTAVPRLNIPSIKLTDGPNGARGQSFFKMTPAVVLPNATGLAATFSPTLPAEAGRLLAAETKARGAVGLLAPTINICRSPLGGRTFESFGEDPTLSGIMAAKYVSALQDDGISAAIKHFVANDQEHERMGQDSIIAPRALREIYLRPFHIAQALAKPWSYMTSYNKLNGTHCSEHEWLLSGLLRTEWGFDGLVMSYWMGTYSVAEAINAGLDLEMPGKPRWRQLSLVRQLMNAHKISPVTIDERVRTILKWVQKLVVLNPDTVYGRDDSIEWTRTEDQAADAALIRRIGNEAIVMLKNESARLRPAWCVTPWQGLVDNKPDQVDLRYALGCKGAKFLPVFGEEFTSMDGTTRGFDMLHYAIVDGKQASQPAVSEVWTNSDIMLADFSHPDLGDDYFTEIRALFTAPITGEWQFEISVTGQAWVYIDDRLLADLSKEQKRTSSFFGNGGNGTVITFSITKGKVYKFRLLHDSRKPPLAPGQDSQPLQLIGMKLGSFPAVNEDQTIDEAVELAKESDIALLMVGLDQDWESESYDRPDLSLPLRMNDLIRRVATEAPDTKKVVILQAGSAVSMPWLEHVDAVLWPWYGGNEAGNAIADVVYGTVNPSGRLPITLPKRELDIAANLNFKSARTKTYYEEGIWVGYRHFNARGIEPLYPFGHGLSYTTFDYSDLTVGPSASSSPDSWRISVSARVTNTGTVPGAHSVHFYTSPPPPTMTSLTHPAVTLQAFAKTAVLRPGQSERVTVEMDKFAISHWDELTSTWQAEPGQWHVKIGRDAQTMCIEAPFNVAPGFKWHGL
The following text describes a protein:
Function:
Binds tetrapyrroles and promotes the photooxidative degradation of protoporphyrin IX. Can bind the benzodiazepine receptor agonist PK-11195 (in vitro); this interferes with photooxidative tetrapyrrole degradation. May play a role in the transmembrane transport of tetrapyrroles and similar compounds (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFMKKSSIIVFFLTYGLFYVSSVLFPIDRTWYDALEKPSWTPPGMTIGMIWAVLFGLIALSVAIIYNNYGFKPKTFWFLFLLNYIFNQAFSYFQFSQKNLFLATVDCLLVAITTLLLIMFSSNLSKVSAWLLIPYFLWSAFATYLSWTIYSIN
The following text describes a protein:
Function:
Probable glycosyltransferase regulating the assembly and trafficking of cellulose synthase complexes.
Miscellaneous:
MISCELLANEOUS: In classical Greek, STELLO mean 'to set in order, arrange, send'.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLVQDRAAPSPAKPPKSQIRELPTHQQIRRRFSEPKNLDFSTWFSENLSRIAVFSLLIVTIVAFFFLYNTTDTASLLCFQSQSTQFLQSLSRPQIKWNSIPVVPDKTSPYANFQTEKWIVVSVTKYPTEELKSLVKIRGWQVLAIGNSATPKDWSLKGSIFLSLDAQAELGYRVLDHLPYDSFVRKSVGYLFAIQHGAKKIYDADDRGEVIDGDLGKHFDVELVGLDSKQEPILQYSHENPNRTVVNPYIHFGQRSVWPRGLPLENVGEINHEEYYTEVFGGKQFIQQGISNGLPDVDSVFYFTRKTTLEAFDIRFDEHSPKVALPQGVMVPVNSFNTLYHSSAFWGLMLPVSVSSMASDVLRGYWGQRLLWELGGYVAVYPPTAHRFDRIEAYPFVEEKDLHVNVGRLIKFLLAWRSEKHSFFETVLDLSFAMAEEGFWTEQDLKFTAAWLQDLIAVGYQQPRLMSLELDRPRASIGHGDRKEFVPRKLPSVHLGVEETGTVSTEIGNLIRWRKNFGNVVLVMFCNGPVERTALEWRLLYGRIFKTVVILSSQKNSDLYVEEAKLDHIYKHLPKIFDRYSSAEGFLFVEDDTVLNYWNLLQADKSKIWTTDKVSKSWTSVKPTGNSDWFSVQAELVKKTVSTMPAHFQVNYKDATKNNHETLTVCSSEVFYVPKRLVTDFIDLVDLVGDMDLHYKVAVPMFFLSMDSPQNFDPVLGSMVYKRKSASFNTSSSLYSAKAPAVHPWSISSEQDFIKLVQQMAEGDPLLMELV
The following text describes a protein:
Function:
Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum. Required for normal cellular morphogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 2700 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Note=Late Golgi.
Sequence:
MSLPLKPLTIDSNNKQLDSKQKKFRANVERALERFDSVTEWADYIASLGTLLKALQSWSPKFQNVRYYVPSPYQVSRRLTSSLSPALPAGVHQKTLEVYTYIFEHIGLETLATECNIWIPGILPLMTYASMSVRSHLIELYDNYILLLPQTTLRLLIRPLISSLLPGIDDESNDFLPLTLKLIETLQENLDDDSLFWQTLFLVMTANKGRRLGGLTWLTRKFPSLNAVPHLVNKIKMEAEENPSETETNDSHLDRKKRKEEAFKVLLPAAKDLVTPEPGLLIRCLVGCLEDENDILIKRSVLDLLLQRLRLDSPVLNVLITSEDKKLLIMSCCRTTLSKDMSLNRRIWNWLLGPTAGGMLNNNGGNSMEYTTSVKSANEESNVYFTKYGLSALLEGLSDLLSEEESVLTAFRISMAVMDRWEIGSLVIPELFIPLLYSSEKFKQNEQIMKTARTFFDNTETNIIWGKLFQELEDIKNLKILDFVLTNFNIGNDEEIIVRHLPLILLTLLALPSNDKDFDNIYKLQKFSLYNKLLNYIPERALLPLSHSKLKHDDEVSCEELLAKIRGFYTNVSNPSSILEKENIAERLPPFTTEDLTFLIADLIQKKLLSSLWDLENINESSKLFIAIFEKIPESEELKGRSHISWSDKKITQSIFEAIPRLCESNNDAKSEEIVGIVEIFGNYLYSRMEFIESMKLLKVVMMAVWKSLKDPRHQILGVKNLKTLNRFIPSKFIESALVYTFVEEEDISERLSVLDLLWTQLDSDSNLIRRPLELILGELFDDQNPFYLTVSKWILSILNSGSASRLFYILTDNILKVNRLEKERLDERDDLDMLTYEFQMLAYVLKTNNGRTRKVFSTELTSIKSSTIWKNEDVSTYKSLLLVTLMRFLNIKSNTHAKSIRSALILLDILLDGTEQNFKDIVIFLLQMSSKYIAEEGIEPELIAVSLLDIVSKVLRLSHDNGIKLDIFDDNAAHLKYIDFLVTSVSNMKSPLIVTAYVKLLSESIVYFENSIFRMILPLSASLVQCVQRLFLLEKREGGYYQPIALLLGGLEELLEISHGYLVTEEREGYFSGSNLKGDFIQSVVSNVFSSDSSNEESKIQGERDVILQSFRQVISCCLDIWYWAHNISCKSNDDSSLDATNHNSYKFKFRSKKLLETLFLLEPLELLENLISIRSDNTTVTLVHVLDGNKPAITIPHLLYGVIIRYNRTASVKFSNRDGSRSSTTKLTKGEPSMLKRLSGESIIAFLFNYVDSVENSAMEEFYGDFLLFFREVATNYNLYSDVSLSILKLVALISGKVSKTQFGEQKRVRREISDVFFKYLPNAFINFTNLYRGHPDSFKDLEFVVWRVQYIVNDQIGGDKFNTTLATIVNQCLTPYIKPKSEKTIPGYVLELAAVVSHLGSKVKSWRLLIAELFQNDKKLSVIGSDQTWEKIIYEWSIYPENKSKILNDLLLEIGSKRSSVTPTLITFNLGSDSEVEYKCQNLLKISYLLMVSPNDAYLLHFSSLISCIFHYLVSKDIKLKGSCWILLRVLLLRFSESHFNDYWSMISYCLQTNLQEFYESLQIQSEVDPQTILQVCKTLDLLLLLNMEGFTSTNEWIFVIDTINCVYKTNSFVALVDEIAEFKDYEITKTDDLELPTTLKDGLPLLRGIHKIERHTQLRSFFQNLSYLHYEKVYGLGSVDLYGCGEDLKKDILS
The following text describes a protein:
Function:
Methyltransferase that may methylate 1,7-paraxanthine. Prevents seed germination and modulates root architecture during early seedlings development. Plays a minor role in defense responses toward pathogenic bacteria (e.g. P.syringae).
Sequence:
MTTTPDWIMIGGDGPESYNQQSSYQRALLEATKDKMTKAISANLDLDLISNRFIVADFGCASGPNTFVAVQNIIDAVEEKYRRETGQNPADNIEFQVLFNDFSLNDFNTLFQTLPPGRRYFSAGVPGSFFERVLPKESFHIGVMSYAFHFTSKIPKGIMDRDSPLWNKDMQCTGFNPAVKKAYLDQYSIDTKILLDARAEELVPGGLMLLLGSCLRDGVKMSETPKGTVMDFIGESLSDLAKQGVTEQEKVDTFRTSIYFAEQGEIRQIIEENGKFTIEAFEDIIHAKNEFPFDPKTLAISFKAFYGAFISAHFGVEVMRKAFELVEVKAREQISRLHNSKPGMQYLIVLRKN
The following text describes a protein:
Function:
Xylosylphosphotransferase that is specific for UDP-xylose as a donor and mannose as an acceptor to form a xylose-alpha-1-phosphate-6-mannose linkage. Functions in the O-glycosylation of proteins en route through the secretory pathway (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MPPTALPPLRPPAQPYDSYSSSLSPSSPRFHPASAPHGRRAPSPSRLESLLDAPHAPARSPSRKIRSALSRHIRPHLTPRTLTPLLLWTLALWLVHHFLFPFSSPLAALSRPKAEQHFLSTTFPPPPQRLGDDRLDSVDPRWRAFHPLPPPEPPFPRLRPTRFLPPQCLEQWFADGETLCGAKEMGEEETLDATWLWVNGSDHRWRDSMAEWREKENVNSPERHFREQNELVHSMRSVLDALPGHLRTFHLILADYPFNYPEDLDLVPPSIIPDLEVAASKGGQGRRHPRELARAPASVSNLTERLTPESISPSLARHLQSEWRILQTPTWLDFSRRDPSDPSHPFHPYSVSKAGEMRQHYAEASYPTLRYASHWEVFHIPSVDRDGREELMGEREWRENEWKKKALPSFNSMAIESRIGWLPGLADAIIALNDDFFLLRPHAVSDFHSPLYGSVIRFEHSYNQQVKPDVEKNHINDPGEMGGLYHANALLSRRFPHRLRPYFAHVPKVITRGLHHEASLMFQEALTLSSTRKFREMKIGEGDVQMQWLLTSLRVERWREALLWTWVVANMGTLSGSHDRWDSDTRSAIKHLFGFTEDDDDVVKIEVHRGERWTLEPGRMQKVFHQAGWEAPKATEFLFSSMDGIMPPLLRSGEDPSQNDRCIIDLNRCFGVFWTRQEDVLSADMMKRLTFQYPECGDCMIMALVTASGTLGLNAFFPPKETTITAPELGPGDAYPKYLPPPHLPLTPTWHEADYSLSNILSTTALPGEQVDIRQYCMRLLSRYLYLDAKSVSHFHMMKSAEHAKRVFKMIQDNPKVSILGMNDDIESDYDEVKRLMNEWFEMRWPRKAVWERDWDPVKDRYHD
The following text describes a protein:
Function:
Potential transporter for phosphate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MITIEISINLELIISFYLLFILGANNVANAIGTAYASRATTYRNLLILFSISVIIGSLFAKNVGSTVNSLSSDALTALIISALVMTLSTYKKVPISLHTVIICSLIGLNFNSSNLYVFGEILLSWILSPIIAVVIAYILYSAYEKIDISILKKITMIRYFLLISAAVVAFNLGSNDLPTVLGTFTTSQIIYIIGAIFLCLGAYLYGNRVSETLSMITNLSVSSAFIAQLSGGLAVTIFTALGMPVSTTQAIVGGILGVGLTKGIKTVRWKVLKNIIFWWVVAPIIALIIGFIINRMI
The following text describes a protein:
Function:
Aldo-keto reductase that significantly contributes to cellular methylglyoxal detoxification by catalyzing the NADPH-dependent conversion of methylglyoxal to acetol.
Subcellular Localization:
Cytoplasm.
Sequence:
MANPTIIRLQDGNVMPQLGLGVWKASNEEVIAAIHKALEVGYRSIDTATAYQNEEGVGKALKAASVAREELFITTKLWNDDQKRPREALQESLKKLQLDYLDLYLMHWPVPAIDHYVDAWKGMIALQKEGLVKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGEGVFDQKVIRELADKYGKTPAQIVIRWHLDCGLVVIPKSVTPSRIAENFAVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG
The following text describes a protein:
Function:
Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.
Subcellular Localization:
Nucleus.
Sequence:
MPNMSSIKAEQQSGPLGGSSGYQVPVNMCTTTVANTTTTLGSSAGGATGSRHNVSVTNIKCELDELPSPNGNMVPVIANYVHGSLRIPLSGHSNHRESDSEEELASIENLKVRRRTAADKNGPRPMSWEGELSDTEVNGGEELMEMEPTIKSEVVPAVAPPQPVCALQPIKTELENIAGEMQIQEKCYPQSNTQHHAATKLKVAPTQSDPINLKFEPPLGDNSPLLAARSKSSSGGHLPLPTNPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPPAGTLYGNHHGIYRQMKVEASSTVPSSGQEAQNLSMDSASSNLDTVGLGSSHPASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAAAAAAVASQQQPHQRLHQLNGFGGVPIPCSTSLPASPSLAGTSVKSEEMAETGKQSLRTGSVPPLLQEIMDVEHLWQYTDAELARINQPLSAFASGSSSSSSSSGTSSGAHAQLTNPLLASAGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSIDTPGEIKMSQGRKITLSQAKSNGLQTCIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADFNLLMELLRGEH
The following text describes a protein:
Function:
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies.
Subcellular Localization:
Nucleus. Note=Associates to transcriptionally active chromatin at snRNA genes.
Sequence:
MNLDEFSDFNIDQLLGPSAPLQDALVAPYKQVSLPRSNQDVYAKRSRLAERIAQNDELIRQVKQLQAQNKQLADLQRTAQEVTDLYQKEKQQRIELEKRTKQIGERCGQLEKELDVQVGNCENLQEQLQVRGLPVEAKDVLSILMQFSQRLGDDCGLLRRDQNIMKKLREHCKTIDVSVPTPKSPNSRSKRKAHQPGVNQSTQTDEEPADPKPALCSVAVQVEGLIETRNQATQHKNTTTTRGTTTASFIKHHDVGTCFPEPKPLPNIRQILDEMLSWRDDVVIEPMSPLSDLQQELQLEDVPTNASVATCTTLCDIHREIDFVTDLPTQIKVSASRPPSRTMLDSVKEEARSSRELAKELFNFLPQNQSCLTNLPPQAFEELWQVFGQMVLALLQRRSNPSMATPPSVSQADFTRWLYELYEGTENQTEQTSNGSTSKRDFATSTECMDTGTDPIIQSPNISHEGHVTPIRLPSKPKERKRKSKKRKAAATPKPIAKRKCLEMETNNELEVEREQTPETAIQFLSNLETFNMANCDNLEMELDEEELYLLQLTSNAKQNENKGNVRVQDPDDLKSPAQTSKFPKSENHLPAVLKETASSLKGYDEKQCPFPDKTEELMHKKTFEIQENIGSLTELPPNIDISAYPVSMAEVRIVSSNKPSEMEVNASEGTDSHLDKSVSNLDTGSMSLFGSDSDVESEYSIEQMAPELSDSDDTFDNSEEDCRSADEPSNSKKIRNSSLFGSESESDESEERALEADDLTEAEAKVEEKESEQKSSDVAPAASSGKLLVVEADLVTKTQPLFVEKLDLENTQHTSTCTNPKETDESEDEHGLVIDEQIFISQPEEPPLTVPIAAKRRRTQSELKTLSPPGEVRLTRQRAKQLLDEQKSGPEKGLSLVEQIRRQLKKAINKSEPFKKDSTHDSKKDSTHDLKPLEHEDELKAMQLGTNFEPIKLSCSISEESPASPPACEPMDELDPPPIEIPLEQAACTRKDDQHKSIVQHVLKMDTGLEKLVEANRKTLGKSQPQLCASIGKYLQENMQLESTCSDLAMDIYKVTKSEAVIVNAMITVICKIGLDDGPVERLLNALKYLNFSQRFLAELEERLFRNTKERPATELALNYVRLYLKATALQATMSAGYENPARLLLAKILYHFDQDMPPLVMEVLRQFPTALPHREQREYDNSDALITVIKHLLMNRQYDMQDPNGAERLLLSKLRFEYHFQPYEPSKQQVLENLVGKLKAGREEELGYAFALFCRRSPHLKVVESVVGEHLMPLATSYCDLAAQNELYDARLGLLLHCISLVLKPLPLDTDISAFVGFLKRLLVAVPRSGVQLAAVKASLRLQRFGFKYTLDALKDYRPNYELDPLTRAMIRCFAKRRRHFRHVAATGRRTEI
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKITQKRKVNRYMSFFRNNFGFRVPYQVLIDGTLCLAALEGQVRVSEQLIKYFQCELKLLTTQCVILEMEKLGSSVNGALSICKQFAVHKCGHEKKPVSASKCLESMITNNNPNRYIIATQDPSLREVARTIPGTPILYLHIRSPTLEKPSQLSSELAGFNIQTSIQSQGCTMERLRQIKKQELGTDIKEKPFKRRKPKGPNPLSCKKKKKKANFREPLENVGPSSSQPQRTKRRRRAKIAEHIRQELAARLNVSKV
The following text describes a protein:
Function:
Promotes matrix assembly (By similarity). Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MEVRKALTCVFLTVFLCSGDAQDSVTDSVLNCCEGDVLFLLDSSGSVASYEFSRMVDFLSELLLPFSLGPDHVRVGLLQVGTEPHLEFGFDAYSSQQGLQAALERTKQLKGDTNTVEALLMARAQVLRVGVPGGARPDLPRVLVWLTDGVDPGNVQEPMARLRDEGVAVLVVSTGHGNYQVLREVVSPPTEEHLFFVDIDDISIIGEDLRNSIIEIIRAERLQVKSVSSTSAQLEWRPVLSGSGSGYYDIKFGPMRTGQIPGVPGGASTDPGSFQRITRPADSSSAQLTGLRPDTTYTVTLTPKNNQQVLNTLQTSFTTQTVNPPEPQIQLLSSLSVSESSSNSVRVSWAPLLPRLIQEYQLEYSALPSGPLRVLRVSNTHNSTVITDLQPDTQYLLTVSAKQTSGKERAMTVKVCTQEVLPALSDLQLSSVGDETVQLRWKGSFDGLRGYWVTWERGHSQRSTLYLPPNRLSTTLNHVPSRARVCVSPVYRTARGEGLCCTA
The following text describes a protein:
Function:
Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis.
Miscellaneous:
MISCELLANEOUS: Transcriptional activation activity is enhanced by Raf1, ERK and PKA.
Subcellular Localization:
Nucleus.
Sequence:
MDYKMDGYLDQQVPYTLANRSQGNGPLNRLLMATKRKYMDAELPPQESEDLFQDLSQLQETWLTEAQVPDSDEQFVPDFHSENSVAFHSPPVKIKKEPQSPGSDPSQSCSHKQSFSYPNGEQCLYASAYEQKRAAVAGAGGSKSSCPATPMSPMQHYSPKPTVGTRQESGYMNPPSSSQSHACHSHSYPMNPSSRFPSGSAEMCPPFASQGQALQRIDPAHASGGGGGGYHRQHSDPCLPYPPQQTFKQEYMDPLYDRAAHINGPQPQRFPPAHMMVKQEPTDYTYEPDVPGCPSMYHHNEGYSNPQHNSEGYMFENDSRVVPEKFEGEVKQEGGSVFREGAPYQRRGSLQLWQFLVALLDDPSNAHFIAWTGRGMEFKLIEPEEVARLWGIEKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALITLAFPDNQRPSLKAEFERYVNEEDTVPLSHLDEGVSYPPEPAATNMGPQPYSKGYMY
The following text describes a protein:
Function:
Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.
Subcellular Localization:
Cytoplasm.
Domain:
The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity.
Sequence:
MPRRRKNLGGNPFRKTANPKEVVVSSVASREEPTTTLPSMGETKVDQEELFTSISEIFSDLDPDVVYLMLSECDFKVENAMDCLLELSATDTKIEESSSQSFVASENQVGAAESKIMEKRPEEESEDSKMDSFLDMQLTEDLDSLIQNAFEKLNSSPDDQVYSFLPSQDVNSFNDSSEFINPDSSNMTPIFSTQNMNLNGENLENSGSTLSLNPLPSHSVLNESKCFIKDNTLALESNYPEDSLLSSSLNVASDSIAGCSSLNQKQKELLESECVEAQFSEAPVDLDASEPQACLNLPGLDLPGTGGDQKSTRVSDVFLPSEGFNFKPHKHPELPTKGKDVSYCPVLAPLPLLLPPPPPPPMWNPMIPAFDLFQGNHGFVAPVVTTAAHWRSVNYTFPPSVISHTSPTKVWRNKDGTSAYQVQETPVSQVVRKKTSYVGLVLVLLRGLPGSGKSFLARTLQEDNPSGVILSTDDYFYINGQYQFDVKYLGEAHEWNQNRAKEAFEKKISPIIIDNTNLQAWEMKPYVALSQKHKYKVLFREPDTWWKFKPKELARRNIHGVSKEKITRMLEHYQRFVSVPIIMSSSVPEKIERIELCAYSCEDRSTSPRDDEDIISEKEENILSLSLKHLEFTEEKNLDVTKETMLPENVAYLSNADLNKRRKEISDMNPSIQSALILETPHMYFSDSESKLQATDKSENEQIEMVAVKGYSKTDTDSSMERVSPSTCCSENNQEDCDLANSGPLQNEKSSPGEIVEERATVTKKAFGKQKSKSTLEKFPRHELSNFVGDWPVDKTIGQRTKRNRKTEKTSSVQSDKKYNYPQSHKLVNSVSVNTDCVQQRGSPHESVEDGRKSQCDDASEPLNSYKYDAYKNIDKNSFNIMGDWPSSDSLAQREHRSRMPKTGLSEPNLEIGTNDKMNEISLSTAHEACWGTSSQKLKTLGSSNLGSSEMLLSEMTCESQTCLSKKSHGQHTSLPLTFTNSAPTVSGVVEPQTLAECQEQMPKRDPGKEVGMCTQTEPQDFALLWKIEKNKISISDSIKVLTGRLDGFKPKVFNINTKSDVQEAIPYRVMYDKSTFVEESELTSADESENLNILCKLFGSFSLEALKDLYERCNKDIIWATSLLLDSETKLCEDTEFENFQKSCDGSQIGPFSLGLNLKEIISQRGTLENSNSPVPEFSHGIGISNADSQSTCDAERGNSEQAEMRAVTPENHESMTSIFPSAAVGLKNNNDILPNSQEELLYSSKQSFPGILKATTPKDMSETEKNLVVTETGDNIHSPSHFSDIFNFVSSTSNLELNEEIYFTDSLEIKRNENFPKDYVKFSDEEEFMNEDEKEMKEILMAGSSLSAGVSGEDKTEILNPTPAMAKSLTIDCLELALPPELAFQLNELFGPVGIDSGSLTVEDCVVHIDLNLAKVIHEKWKESVMERQRQEEVSCGKFMQDPSLVGHTGLDNPEQKSSQRTGKKLLKTLTASEMLPLLDHWNTQTKKVSLREIMSEEIALQEKHNLKRETLMFEKDCATKLKEKQLFKIFPAINQNFLVDIFKDHNYSLEHTVQFLNCVLEGDPVKTVVAQEFVHQNENVTSHTGQKSKEKKPKKLKETEETPSELSFQDFEYPDYDDYRAEAFLHQQKRMECYSKAKEAYRIGKKNVATFYAQQGTLHEQKMKEANHLAAIEIFEKVNASLLPQNVLDLHGLHVDEALEHLMRVLEKKTEEFKQNGGKPYLSVITGRGNHSQGGVARIKPAVIKYLISHSFRFSEIKPGCLKVMLK
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFQTLVNFFKVADIRKKILFTLAMLVIFRIGTFVPVPGVNAAALQSSMDGGILGFLNTFNGGALKNFSIFAMGVMPYITSSIIVQLLQMDVVPKLTEWSKQGEMGRKKLNQLTRYMTIGLGLVEAFGMAYGFNRMSSAGLVIEPSIGRYAIIAIVLTTGTMFLMWLGEQITVKGVGNGVSIIIFAGIVARIPDGVRQLYVSQIENAGDQLFLHVLTLVGVGVAILAIVVAVIFFQQALRKIPIQYSKRVAGAKQSGAQATHLPLKLNSAGVIPVIFASAFIITPQTILTFFDQSNDVVKVLKDVFDYTKPIGMILYVALIVAFTYFYAFIQVNPEKVADNLKKQGGYIPSKRPGRETQAYLTSVLYRLTFVGAIFLSAVAILPTIGTTVFSLPQSLAVGGTSLLIVIGVALDTTKQLEGQLVKRNYRGFIK
The following text describes a protein:
Function:
Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRDFVTGTTVVSFRYRDGIIMGADTRGSYGRLAKLSGVQRIFKVGDQTLLGMSGEISDMQYLVKTLTILTQEDNRRIDPKGYHKMIQRILYSARSKISPLNLSVCVGGLNAASDGDRRTHTREKMLGCVNHLGNFYFSDVVCTGIGGYLVLPFLRNRVEGREEEIAREEAIGLVEEAMRILCYRDCNASNEIQVGYVDDQGVHISDPYQIKTNWDVGLREDEIVIE