lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Domain:
The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).
Sequence:
MSGVNSDLLHRSTLSVYNNLMDQFNPGLQKLVTLGNSYIKAFQALALTSEAYFSALAKMGEQALSTLSSRSLGDVLIQISETQRKLTAEAEGVFRWFHVEVLQAMDKNVKLDEEYIEGSRRVYELEVRNQAASLERQLRRGAFRDSLESSEYMQYLRQSQHEILKEEERRYRFLAEKHCGLTQSLLYLINKTGVSLQQRADGWKEKVSESRSSRPRTPTPLDQEAQLKSSVGSLLQTGDREMDREPLGRVPSRAPSPLPSRSRSSSVGESLGLGGGRSMRAIVSHPASSNPVLLPFARGDLLTVLIPEPRNGWLYGRHDPSLRQGWFPAAYVASTEDFLPVGLSISHRSHSMNNLLEPTSQSESDTQTYSEVSSPVVSMRRASADVRSVSPLPEKKTESNNELKSGQKVFHEIPAPATQLRRGSADVRSISPLPDRRAESHFESKVELKNYNELPPPAPPLPNSPLPERKTDLTSERPSTQGQPPEHPLFPRGSNPFATVKLRPTVTNDRSAPRIQ
The following text describes a protein:
Function:
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells; IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity); Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MNSFTSALRPGPLGCSLALLLVVATAFPTSAPVREDSNTKASPDKTLTPPGRTIESIRSILETIKELRKEMCDHDVNCMNRKEALAEVNLHLPRLIEEDGCFPPAVNNETCLLRITSGLMEFRMYLEHLQAKFRSDEENTRVSMVLKNIQHLIKTLRPKVKNLNEEATLKPAVAVSLMENLQQKNQWLKTTTIHFILRGLTNFLEFTLRAVDLMECGCPCLRNFMGSASHGQNTPSCPLDT
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MKIAIPVVITLLLDVFLTRLKEQSFLNTTIDRTITVFTRTSSSSSGISTKWAIILAVILVAGIFLVTIVLLLLYYYGCTKCIIVWMVIAVTLLLSYYVYLAVGEIPSLENWPIDWITVVFFLLNIVIVGNMAVFWRAPKIVTQIILILISVMTCCVFLFLPDWTVWLLLGMLVIYDICVVLCPRGPLQLLIKKSQERGDAIPALIYSSAAYTWKDGPEEEEESHEIQIDRSTEQEENNQSNEPSTHESNEQTNQETNEQEDKKPLEKDPENGHHKKHKKRRPKKFPLGSKKIHPAEPKELNSEQSTESSSSSSSSSSSEDDSEALELESKEGIKLGLGDFVFYGILISRAARKGWDTSVVCIEAVLLGLSITLIFLAILERPLPALPFSLVLGIIFYFIMPYTLKPFALNLRKLLLVY
The following text describes a protein:
Function:
Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.
Sequence:
MLAIAAFLVLLVSGDGIPISKEKVISRDLVDKINTLNVGWEATLYPQFENLTFESAKSMLGSRGAWPEGSLPPEIEVRVAENIPENFDARKQWPGSIHPIRNQGQCGSCWAFGASEVLSDRFAIASKNQIYVTLSAQQLVDCDLDNSGCSGGWPINAWNYMVKTGLLTEQCYGPYYAKQYTCRLTANTTDCPWQPGVKARFYHAKSAYKLPAKNVEAIQTDIMNNGPVEADFTIFQDFYAYRSGIYVHATGKQLGGHAIKILGWGTEDNVDYWLCANSWGANWGIQGYFKIRRGTDECGIEDGLAAGLPLL
The following text describes a protein:
Function:
This protein functions as a defense against chitin containing fungal pathogens.
Sequence:
MLKLWFSPLSNLCFTPYTLSKMTKHQFLLSVLFLALQTPIASAIAIYWGQNGNEATLNETCASGRYSYVNLAFLNKFGNGQTPEINLAGHCNPAGDGCAAVGPELKLCQNLGVKVMLSIGGGVGNYSLASREDAKIFARYLWNTFLGGNSSFRPLGSAVLDGIDFDIELGSSLYYDDLAKYLKDYGKIGKKVYLTAAPQCPFPDSLLGTALNTGLFDNVWVQFYNNPPCQYTPNNTDNIENSWIRWTSSVNATRIFLGLPAAPQAAGSGFIPADVLIGKILPVIKKSRKYGGVMLWSKFWDEQSGYSASIQEDSEPTRNRSATNVPSTIPIPPALSPAPSPNVTPRSSDSSQRTSLKWWIWLIVAIGLTIFVGLSSLCYLLHRKRKAKATALLLLNQTTNRAKRRKMDKKMSEEVQLYSFGSLAIATSNFSLGNKLGEGGFGPVYKGKLPDGQEVAIKRLSTSSGQGLLEFKNEILLIAKLQHTKLVRLLGYCTQGEERILVYEYMHNKSLDFFLFDTNKKEQINWGTRFRIIEGVAQGLLYLHKYSRLTVVHRDLKASNILLDSDMNPKISDFGMARIFGQQESETNTKRIVGTHGYMSPEYALRGIVSTKTDVFSFGVLLLEIVSGKKNNSCYDSEHPLNLIGLAWELWREERALELIDATLIESCSRDEVLRCIHVGLLCVQDYAKDRPSMSSVVSMLTNGSRKPPPPPERPGFFIERGDQQAQRSEEAERYSINGLSISELKGR
The following text describes a protein:
Function:
During the asexual blood stage, involved in merozoite egress from host erythrocytes possibly via its interaction with the host cytoskeleton protein spectrin resulting in the destabilization of the host cytoskeleton and thus leading to erythrocyte cell membrane rupture. Involved in the binding to host erythrocytes and is required for host erythrocyte invasion; [p33 subunit]: By binding to host proinflammatory cytokine S100P may interfere with host immune responses; [p19 subunit]: Involved in merozoite invasion of host erythrocytes. May play a role in the biogenesis and/or function of the food vacuole during the intraerythrocytic development (Probable).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted; [p19 subunit]: Cell membrane; Lipid-anchor, GPI-anchor. Vacuole membrane; Lipid-anchor, GPI-anchor. Note=In free merozoites, localizes to the cell membrane. Following merozoite invasion of host erythrocytes, p19 subunit is endocytosed into small food vacuoles in the ring stage and persists throughout the subsequent intra-erythrocytic stages at the surface of the food vacuole where it forms clusters.
Sequence:
MKIIFFLCSFLFFIINTQCVTHESYQELVKKLEALEDAVLTGYSLFQKEKMVLNEEEITTKGASAQSGASAQSGASAQSGASAQSGASAQSGASAQSGTSGPSGPSGTSPSSRSNTLPRSNTSSGASPPADASDSDAKSYADLKHRVRNYLFTIKELKYPELFDLTNHMLTLCDNIHGFKYLIDGYEEINELLYKLNFYFDLLRAKLNDVCANDYCQIPFNLKIRANELDVLKKLVFGYRKPLDNIKDNVGKMEDYIKKNKTTIANINELIEGSKKTIDQNKNADNEEGKKKLYQAQYDLSIYNKQLEEAHNLISVLEKRIDTLKKNENIKKLLDKINEIKNPPPANSGNTPNTLLDKNKKIEEHEEKIKEIAKTIKFNIDSLFTDPLELEYYLREKNKKVDVTPKSQDPTKSVQIPKVPYPNGIVYPLPLTDIHNSLAADNDKNSYGDLMNPHTKEKINEKIITDNKERKIFINNIKKKIDLEEKNINHTKEQNKKLLEDYEKSKKDYEELLEKFYEMKFNNNFNKDVVDKIFSARYTYNVEKQRYNNKFSSSNNSVYNVQKLKKALSYLEDYSLRKGISEKDFNHYYTLKTGLEADIKKLTEEIKSSENKILEKNFKGLTHSANGSLEVSDIVKLQVQKVLLIKKIEDLRKIELFLKNAQLKDSIHVPNIYKPQNKPEPYYLIVLKKEVDKLKEFIPKVKDMLKKEQAVLSSITQPLVAASETTEDGGHSTHTLSQSGETEVTEETEETEETVGHTTTVTITLPPTQPSPPKEVKVVENSIEHKSNDNSQALTKTVYLKKLDEFLTKSYICHKYILVSNSSMDQKLLEVYNLTPEEENELKSCDPLDLLFNIQNNIPAMYSLYDSMNNDLQHLFFELYQKEMIYYLHKLKEENHIKKLLEEQKQITGTSSTSSPGNTTVNTAQSATHSNSQNQQSNASSTNTQNGVAVSSGPAVVEESHDPLTVLSISNDLKGIVSLLNLGNKTKVPNPLTISTTEMEKFYENILKNNDTYFNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDTLQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPHNVLQNFSVFFNKKKEAEIAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRVLSKIDGKLNDNLHLGKKKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLPEAKVTTVVTPPQPDVTPSPLSVRVSGSSGSTKEETQIPTSGSLLTELQQVVQLQNYDEEDDSLVVLPIFGESEDNDEYLDQVVTGEAISVTMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKHISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEKEKFPSSPPTTPPSPAKTDEQKKESKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKDEAHVKITKLSDLKAIDDKIDLFKNPYDFEAIKKLINDDTKKDMLGKLLSTGLVQNFPNTIISKLIEGKFQDMLNISQHQCVKKQCPENSGCFRHLDEREECKCLLNYKQEGDKCVENPNPTCNENNGGCDADATCTEEDSGSSRKKITCECTKPDSYPLFDGIFCSSSNFLGISFLLILMLILYSFI
The following text describes a protein:
Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type III membrane protein; [Isoform 2]: Cell membrane; Single-pass type III membrane protein; [Isoform 4]: Cell membrane; Single-pass type III membrane protein.
Domain:
Neither C2 domains mediates Ca(2+)-dependent or -independent phospholipid binding.
Sequence:
MAEQLALVIGGTIGGLLLLLLIGASCCLWRRFCATLTYEELPGTPAMATTAASSGQRDRPCQPHARTQLSRPPAVPFVVPPTLQGRDWVPLHSGEWADAPWDPCPASELLPHTSSGGLGDACMVGAINPELYKFPEDKSETDFPDGCLGRLWFSVEYEQEAERLLVGLIKAQHLQAPSETCSPLVKLYLLPDERRFLQSKTKRKTSNPQFDEHFIFQVSSKTITQRVLKFSVYHVDRQRKHQLLGQVLFPLKNETLVGDCRRVIWRDLEAESLEPPSEFGDLQFCLSYNDYLSRLTVVVLRAKGLRLQEDRGIVSVFVKVSLMNHNKFVKCKKTSAVLGSINPVYNETFSFKADATELDTASLSLTVVQNMEGDKSQQLGRVVVGPYMYTRGRELEHWDEMLSKPKELVKRWHALCRTTEP
The following text describes a protein:
Function:
Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation. May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).
Sequence:
MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVASTPVSGSLFLASSAPHR
The following text describes a protein:
Function:
Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Also shows permeability towards NA(1+), K(+) and Mg(2+). Heterotetrameric complex channel is activated by external low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus. May act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFFKGGSWLWLYIRTSIILGSKLNSPGPHGQNNCYQFNRFHCSFEEAENYCHGQRGFLARIWNQEVEDLIRDFLEEREKWWIGQNVMRLRKHQGENYPADVAAHGAPKPPSCTYLSRNLNRILSKEDKCFLRHYFICQTDGVLDRDAHYERNGNDSHLYERPEKTKRGVGIARDKMPPGPGALSATCHHPLPAHLSKTLCHPISPFPSVLQNITSQVTATSEASSQPLPVITQLTTPVSVTRAGQSLAETTSSPKEAAHVNTVTSHLQVSLQNASGQVIDEIAGNFSRAVHGLQAHNKLQEACEFLQKLTALTPRFFKPAQVNLINSLIYLSEELLRIPFLNSSSLDFKVPATVCPFHSFNNVTKAGEGSWLESKSDTEQVEDILEMSLAELGNIGEAFLEQDQSAESSVTLTSSVATLLLSRQNTSTLPLSSYTLGHPAPVRLGFPSALALKELLNQHPGVNVQVTGLAFNPFKDLDHRNVVGSVGSVLLSANRKLLQVHDLVEDIEIMLWRNVSMETHPTSFNMSTDQLTITVNITSLEKSLIVSIDPDSPLLMTLYLGFQYQPNCTHFHLNITLPKDKVWQKDEEYTWVLTPEHLQHGIGTYCIRAVLSESQKGAQQTPSLVSVITAVTQCYYWESHNQTWSSNGCQVGPQSTILRTQCLCNHLTFFASDFFVVPRTVNVEDTVELFLRVTNNPVGVSLLAGLLGFYVITVVWAWKKDQADMQKVKVTVLADNDPSAQFHYLIQVYTGYRRRAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTRSSLGDLHSLRLWHDNSGISPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVSKRQLFSFRHLFSSMIVEKFTQDYLWLSVATRHPWNQFTRVQRLSCCMTLLLCNMVISVMFWKINSTTAKRDEQLGPFAVAWSELLISIHTAVILFPINLVIGRLFPLIEPQETLPLFPPVQASCLSDASAEPLSATMVVEELKETVRFLLRRNTYLLSKCEQPPWSSCDVTKLVKLLSSLISSHLEGQSCHQQAERHWARVVPENHHHFCRYLRRALQRLQSHLGTLGLARGHQPCDFLDAASQLQTLQQLLETHILPMEQEPSREVTSFAILSSEEGKKPISNGLSRWLTAVCWLLLGLTSLASAFFTALYSLEMSKDQATSWMISIILSVLQNVFISQPGKVVFFTFLHSLMMSRMPRLNKEKEQQTKRILALLAKCSSSVPGSRDKNNPVYVAPAMNSPTKRPERTLKKKKLFKLTGDILVQILFLTLLMTAICSVKNSNRFYLHQAIRKTFSPRFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLKPIHCKYGVQFIFQIPCTTIYEKVEEGQLVFSDKAVPVGIPRAFTSVHPGPWGRFPADELHKRLTSKNDSGFSYIMRSAFFTSVRLESFTSLQMSKKGFAWSIISQVIYYLLVCYYAFKLGCRLKRQKWRFFTGRRNILDTSIILISFIILGLDMKSISLLRKNMARYHDDRDRFISFREAVKVNSAATHLVGFLVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAVAFNLLFGCSISDYRTFFSSAVTVVGLLIGISHQEEVIDLDPVLGTFLILTSVILMVLVVINLFVSAILMAFGKERKSLKKEVALIDTLLQKLSNLLGISQPQKTSSEQAATTAMGTDTEVLDELP
The following text describes a protein:
Function:
[LURY-1-1]: Acts as a ligand for the npr-22 receptor and controls food-related processes including feeding, lifespan, egg-laying and roaming behavior. Secreted in the presence of food, leading to reduced feeding and roaming behavior and increased egg laying and lifespan. Activity may be latent under normal conditions but induced under conditions that cause hyperactivation of the pharynx such as abrupt refeeding after starvation; [LURY-1-2]: Acts as a ligand for the npr-22 receptor and controls food-related processes including feeding, lifespan, egg-laying and roaming behavior. Secreted in the presence of food, leading to reduced feeding and roaming behavior and increased egg laying and lifespan. Activity may be latent under normal conditions but induced under conditions that cause hyperactivation of the pharynx such as abrupt refeeding after starvation.
Subcellular Localization:
[LURY-1-1]: Secreted. Note=Secreted from the M1 and M2 pharyngeal neurons in a food-dependent manner with secretion positively controlled by the presence of food; [LURY-1-2]: Secreted. Note=Secreted from the M1 and M2 pharyngeal neurons in a food-dependent manner with secretion positively controlled by the presence of food.
Sequence:
MLTRVPVLILAVIVMLALCQEPEKPEKRPALLSRYGRAVLPRYGKRSGNLMESSQNSLTEESSDVVCQLIDGKYICLPVDAVRFRPFFL
The following text describes a protein:
Function:
Necessary for chloroplast and nuclear photorelocation movements via the regulation of chloroplast-actin (cp-actin) filaments in mesophyll cells, and together with PMIR1, in pavement cells. Required component for both the low- and high-light-dependent chloroplast movement responses via an abscisic acid (ABA) pathway. Involved in the ABA response pathway during seed germination. Modulates ABA accumulation during periods of water deficit at the seedling stage.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGEYSGSRSSNTQLLAELEALSENLYQKPQVSVGNRRTNSLALPRSSVPSLVTSADEVSTARAEDLTVSKPRARRLSLSPWRSRPKLEVEEEENVTQSNRIVKKPEESSSGSGVKEEKKGIWNWKPIRGLVRIGMQKLSCLLSVEVVAAQNLPASMNGLRLGVCVRKKETKDGAVQTMPCRVSQGSADFEETLFIKCHVYYSPANGKGSPAKFEARPFLFYLFAVDAKELEFGRHVVDLSELIQESVEKMNYEGARVRQWDMNWGLSGKAKGGELALKLGFQIMEKDGGAGIYSKQGEFGMKPSSKPKNFANSFGRKQSKTSFSVPSPKMTSRSEAWTPASGVESVSDFHGMEHLNLDEPEEKPEEKPVQKNDKPEQRAEDDQEEPDFEVVDKGVEFDDDLETEKSDGTIGERSVEMKEQHVNVDDPRHIMRLTELDSIAKQIKALESMMKDESDGGDGETESQRLDEEEQTVTKEFLQLLEDEETEKLKFYQHKMDISELRSGESVDDESENYLSDLGKGIGCVVQTRDGGYLVSMNPFDTVVMRKDTPKLVMQISKQIVVLPEAGPATGFELFHRMAGSGEELESKISSLMAIDELMGKTGEQVAFEGIASAIIQGRNKERANTSAARTVAAVKTMANAMSSGRRERIMTGIWNVEENPLTSAEEVLAVSLQKLEEMVVEGLKIQADMVDDEAPFEVSAAKGQKNPLESTIPLEEWQKEHRTQQKLTVLATVQLRDPTRRYEAVGGTVVVAVQAEEEEEKGLKVGSLHIGGVKKDAAEKRRLTAAQWLVEHGMGKKGKKKSNIKKKEKEEEEEEMLWSLSSRVMADMWLKSIRNPDVKLH
The following text describes a protein:
Function:
DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor). May function as part of an mSin3A repressor complex. Has no intrinsic transcriptional activity. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B. Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor.
Subcellular Localization:
Nucleus.
Sequence:
MQAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKGDNTSQVVQDDQVKGPLRVGSTVEVKSPDGLFHEGVISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSSLPVAEDEKEEESSEEEDDDKRRLNDELLGKISCVQSSSDKTASYIALVISPSCSDDLAIKKDQCLVRSFADSKFYTVARKDVHELDANSISKPEYSTKRGHEEAQLFLKARTVPESWKMDMSEILESSSSDEEDGGRRDSEDDEEKEVEVEEPEEEPDPEERDHFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIESGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSACIEFRTIHHNDPKPAVKVEKKADVTEVEKDLEEEEEEVSEDQEETVGEEALTGGEEKPLAEESDSSSESEKEEQKEIRYPRGRRRCTVTPVRSEGKDAIKLERVKESEQADEVGDGKKDRQESEIPGKRGPPRAKAERRSRRLEESDRESEEEEQDEQQQEEDEEEEEEEEEEEEEERGSLFSRRNMGERENKEEAEEDGEEDHCLTGTKVKVKYGRGKTQKIYEANIKNTEMDDGEVLYLVHYYGWNVRYDEWVKADRIIWPVDKSGTKRKQKKRVKNKDEGEKEEKKEEEKQSKSKRGRPPLKSTPPNSSRSVSKTPSSDGRASCKSARLSDASALPNGVGTPRRRTRRTSGMTCDSDRGSNDSGNSSEESEAEDTPGKKADRADIPDAAQGGEAEDDKSSAEERELEQECPRSPQEQRREPPMLSEEEEQAEEKETEKSPKPRGRRSRSKEPSSEMSKPPTTNHTESTDTCLLTPEKAEPAEIAEALEDAEQELKDSDTDSASEDVCKEDKRPVKRKAGEQQVADKKVRLEKREEQKTVSPEKKMEVDGIFRGGCEDSLPDDIVNKMEMPSLTPEVVPPVKDGTEVGPEKPADESELKEEEELMPQIGLEALMCHEVDLDDLDEKEKPPSEETVDDKSRALSLADVAAGSQQGFPVASPAAAPSPDESHSTKSESDTTIEVDSVAGESQEGLCESESANGFDASTSSSNCSLSLQERDSKDRGQKRSMDCNNSLSAKKQKRNQKRTSVASKNEKNGAGHSSDSEDLPAIENPSKCTPVKHSGVSKANKLARSPARVTSPSSKDADKEKHREKHAFPSPRTYKWTFQLTELDSMTSTERITFLQDKLQEIRKYYMSLKSEVASIDRRRKRLKKKEREVSHTTASTSSGSSDTGMSPSSASPTQNTVAVECR
The following text describes a protein:
Function:
Plays an important role in the biosynthesis of the phospholipid phosphatidylcholine. Catalyzes the formation of CDP-choline.
Sequence:
MAINGDDKVSGEETASSNRPVRVYADGIYDLFHFGHARAIEQAKKSFPNTYLLVGCCNDEITNKFKGKTVMTESERYESLRHCKWVDEVIPDAPWVLTTEFLDKHQIDYVAHDALPYADASGAGNDVYEFVKSIGKFKETKRTEGISTSDIIMRIVKDYNQYVLRNLDRGYSREELGEKRLRVNVKLKKLQEKVKEQQEKIQTVAKTAGMHRNEWVENADRWVAGFLEMFEEGCHKMGTAIRDGIQQRLLRQESEDAEDDESEEISDEDEVAEGDENYHVRKVS
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MGTVNVVRVASRHKLSWYEKFYFYSIGKGLWITLKHFIKAAILRKAVTIEFPEKKRKYSTRFRGMHTMKRDEQGRERCTSCFCCMWICPADAIYIEAAEVTPEIQHLHPEDKYAKKFEIDLLRCIFCGMCEEACPKGAIYLDGPGEMATDNREDLILTKERMMQLVGGPIIGERQ
The following text describes a protein:
Function:
[Isoform 1]: Essential for mitochondrial morphology, functionality and distribution. Contributes to 9-lipoxygenase (9-LOX)-derived oxylipin synthesis, but not to brassinosteroids (BRs) signaling. Required for waving-inducing oxylipin 9-hydroxyoctadecatrienoic acid and derivatives (e.g. 9-HOT, 2-HOE, 13-HOT, 13-HOD, 13-KOD, 12,13-KHOD, 9-HOT, 9-HOD, 9-KOT, 9-KOD and 9,10-KHOE)-mediated root development regulation, including callose deposition, root waving and lateral roots formation. Involved in basal plant defense toward pathogenic bacteria (e.g. Pseudomonas syringae pv tomato), both in compatible (e.g. Pst DC3000) and incompatible (e.g. Pst DC3000 avrRPM1) interactions, as well as against obligate biotrophic pathogenic fungi (e.g. Golovinomyces cichoracearum), probably via the promotion of callose deposition in the cell wall. Confers sensitivity to the herbicide isoxaben, a herbicide inhibiting cellulose synthesis and altering the cell wall.
Subcellular Localization:
Mitochondrion.
Sequence:
MASRCRSLSKPAFSAFRSAMNKPSIRPKSASSFIGVPPSPGFSRPIGQLGSLQSLLPLYSAVASARLTSCLGIDSQNSRSLAQGMLCSANPGV
The following text describes a protein:
Function:
Catalyzes the endo hydrolysis of beta-1,4-linked mannan and galactomannan, but displays little activity towards other polysaccharides located in the plant cell wall. Preferentially hydrolyzes the larger oligosaccharides and has greater activity against non-substituted polysaccharides. It displays tight specificity for mannose at both the -2 and the -1 subsites. Appears to act in synergy with alpha-galactosidase (AgaA) to elicit hydrolysis of galactomannan.
Sequence:
MKTITTARLPWAAQSFALGICLIALLGCNHAANKSSASRADVKPVTVKLVDSQATMETRSLFAFMQEQRRHSIMFGHQHETTQGLTITRTDGTQSDTFNAVGDFAAVYGWDTLSIVAPKAEGDIVAQVKKAYARGGIITVSSHFDNPKTDTQKGVWPVGTSWDQTPAVVDSLPGGAYNPVLNGYLDQVAEWANNLKDEQGRLIPVIFRLYHENTGSWFWWGDKQSTPEQYKQLFRYSVEYLRDVKGVRNFLYAYSPNNFWDVTEANYLERYPGDEWVDVLGFDTYGPVADNADWFRNVVANAALVARMAEARGKIPVISEIGIRAPDIEAGLYDNQWYRKLISGLKADPDAREIAFLLVWRNAPQGVPGPNGTQVPHYWVPANRPENINNGTLEDFQAFYADEFTAFNRDIEQVYQRPTLIVK