lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. Mediates early complex III biogenesis. Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand. Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass type II membrane protein.
Sequence:
MPGGVPWSAYLKMLSSSLLAMCAGAQVVHWYYRPDLTIPEIPPKPGELKTELLGLKERRHEPHVSQQ
The following text describes a protein:
Function:
Immune regulatory cytokine.
Subcellular Localization:
Secreted.
Sequence:
MNSKSNMEASKYCQRKSYPFPLKLDFSGLHSAAFLNSQTISCYRNSLDYQIKMAFGAFSCLVLVAFLFAKTVVAEGRRLSLGQCELNSVSFRELRDNFDAIKENVQTQDIRTDVILLKESVLREVPMSESCCLLRHLLRFYVESIFKHYEPTSNLLRRKTSTLANAFLSIKAKLRECHNQNKCSCGEETNRRFKLVLDEYQKLDKTTAAIKSLGEMDVLFAWMEGF
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MEGDYTDEPLVSCGRPFRHRKDEIDLGDLGLWSVSSAKPGFGVENLRDDSVHTLWQSEGPQPHFIRIEFPKKTIVTQISIFVDVTLDDSYTPCKLSISLGTFKQDLQVVKIIELINPRGWHHIRLVDREEEEPGDDDDDSDDSDSGFAAKGHLFQVAILANHLNGKDTHIRCLKILGPRSQSRQRWDGFGPNRHELLLMHETIR
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MASVARSSALLKQVAAQQSVAANGLRVAAFHTTSRKSLLPPPPQRIEGTVNDPVEVPPPSPSHGSYHWTFDRVVAAGLIPLTVAPFAAGSLNPTMDAVLAATILIHSHTGFGNIIVDYVPSKRVPKARKVFTWGLNAATVLVGLALYEFETTDVGLTETIKRVWKA
The following text describes a protein:
Function:
ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVKIRYTMPFWRFSTFARFLVFLDGALSLALWVTGGHTAYMESSVMHWTILGSIFELACLGLFKMLFVFYAFTKMEDVSLALLDFPFDASLRSCKKSSHIFTIFFSLLSLAYTATKGGLILNAILNDPKYELMHVTYNVLVISSVVFSFLELITALTGPHFMRKLQLIRIEHTVNDEDEEKEKKGSSANLGRVLALAKPEVWLISLGMVGLIGASASAMAAPLFFGRVVDEAVTSTSMAGVNKVVLILFLIFLGGAICSMIRSWCFTLAGTRVVCRLRNTLFASIIRQEVAFFDTNRTGELTSRLSSDTQVVQNAVTVNISMLVRYSFQILGSIAIMFSQSAALTGVLLSVVPIIAIGAVQYGRYVQVIQKNFQDALGDAGTAAEEALSSIRTVRSFIGEPKAIQSYEKEIGKSYHYGKRIAAANGVFNGIVGLVMQGAIALVLWYGGKLVFLNNKDPTQGITVGQLTSFMLYTLNVAMAFAFLSALYGDFMKAVGASERIFMLMDRKPEIPEEGGQEIMDFTGEISLETVTFTYPSRPETKILQDVSFEVQPGQMVALVGPSGGGKSTIVNLLERFYFPDSGQVKFSGVDLASLDPRWFRQRVSLVSQEPVLFACSIRDNISYGRNATDDEIYEAAKMANAHEFVTGFEEGYDTMVGERGIMLSGGQKQRLAIARALIMDPTVLLLDEATSALDAESEHLVQEAIDRAMVGRTVLVIAHRLSTVKHASQVIVIKKGKIAEKGTHQELLDKGGVYKKLVLRQLSTGGGGGGVAETVSNEKNGNIDEELDDIDEADED
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MRTPLKDRAVSPGQGLLLMPHDDEEQAQVRRARAAALGRKSGIGAGVFFTYASASASQESNLLCWEHILELHKNCIKLAAENVEITQSNTWDLKLIDHLSALVQGDDEQDDQDSFQKASCTLEAGVKIYSTRVDSVHFETYKVLSSLNRTAGVNNGSHSETSSMVLVVDGHVDCQQAASNQEEHRNCSSKRSSRTSSTLEASFDSLNVKQIDLAFAVDPLFQQTSALFDEGGAKGLLLNSLSIFQGCEIVFDSWEVPERSMLVQANNDAEQNAAIKLCFIKAMLEHLRKDSEISPSSSEIVKMLDDPYRTTTLAEDAAKQSCNLFVDGDVFSSWQIGDTSDNSVNDADEAFDCTESDEHQEVNYLDEGLEAIDDDIDANLLHGSNPELGDEEGVGGGEVEYTEDGSVVNHTTVQWMNPRLIYQSNAWAGPDHCKYRNPQDGIRGQCKEEISGPFKVKRKKRQPLVIDFENPSEIDLSLFNPAQVVRSTVLSQRRASFNGLLPDDVHYEALDLVHLFLRPSVLRENLIADRQIQRNIPGPSVQDYGYNSGDDSGMDCSHGDWTGIDGDGEIGDPLGTNLVAVRRKIQKVKVNDDETSKQVDVRNLKESLWSHLQNIQATIDEGESEKDARPFQNLLNVLPEDYAATESDDVSVQLCFICLLHLANEHNLRIVDCPTMDDLQIFQV
The following text describes a protein:
Function:
Flavoenzyme involved in polyamine back-conversion. Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine and its acetyl derivatives. Substrate preference is thermospermine > norspermine > spermine > N(1)-acetylspermine. No activity detected when putrescine, spermidine or N(1)-acetylspermidine are used as substrates. Plays an important role in the regulation of polyamine intracellular concentration (Probable). Involved in the production of hydrogen peroxide in response to salt and cold stresses.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTASVIIIGAGISGISAAKVLVENGVEDVLILEATDRIGGRIHKQNFGDVPVELGAGWIAGVGGKESNPVWELASRFNLRTCFSDYTNARFNIYDRSGKIFPTGIASDSYKKAVDSAILKLKSLEAQCSGQVAEEAPSSPKTPIELAIDFILHDFEMAEVEPISTYVDFGEREFLVADERGYECLLYKMAEEFLVTSHGNILDYRLKLNQVVREVQQSRNGVVVKTEDGSVYEANYVIVSASIGVLQSDLLSFQPLLPRWKTEAIQKCDVMVYTKIFLKFPQCFWPCGPGQEFFIYAHEQRGYFTFWQHMENAYPGSNILVVTLTNEQSKRVEAQSDQETMKEAMSVLRDMFGATIPYATDILVPRWWNNRFQRGSYSNYPMISDNQLLQNIKAPVGRIFFTGEHTSEKFSGYVHGGYLAGIDTSKSLLEEMKQSLLLQPLLAFTESLTLTHQKPNNSQIYTNVKFISGTS
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIQHSSSNCAEKPWRSYNMKEVTVQLPKQHDRPDEPWQRHISIDLIWYVLGYTVFHPFVSWVVVLCLRAQYTAYGAPEMLIAVAWSFLMSAIGIFNIISERIAFGAPREVDLAEEVIVITGGVEGLGGLLAETYGMRNANVAVLDVKKVDEDEAEEKGVVYYQCDVSDPKQIEAAAAKIVEDLGPPTILINNAGIVHKKSILDTTTEEVEQTFRVNTLSHFVTLKTFLPHMLREGRGTIVTVSSVLGHLGAANLSAYTASKAALLALHHSLRAELAQIPAAAEIKTILVTPGQMSTQMFADVKPPSNFFAPTATPAMLAKSIIRLVERGESGEVAIPMYSQYVGFFAILPVGVQALVRRWSGLDRAVGKVGLGEKEKM
The following text describes a protein:
Function:
Negative regulatory protein for the citA gene for citrate synthase I.
Subcellular Localization:
Cytoplasm.
Sequence:
MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEISCKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIADTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCLYKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTMKVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYENKKEKKFLDFLSHFHF
The following text describes a protein:
Function:
Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLRFRLNLAAVRSPTLLLPRSIKSSSLVSTVVVRTSTRNISTLLQPFPLPHATTPNNLPTITKRALNTTTPTMASSDTITNWVDPNDKTGEFKRQVSSFRSFISRSDPSSPFPPEKGRYHLYVSYACPWATRALIVRKLKGLEDIISFSSVHWHMGPLGWRFPLAEEGKEGGDAAGDQVVPDPVGGKQYMREVYFGVEPEYNARFTVPVLFDKKEGRIVNNESSEIVRMLGSEFNEIVEDAKARELDLYPEDLRAEIDEVNEWVYHDINNGVYKSGFATTQEAYERNVIKLFEGLDKVEKHLKEVQKKGKGEFWFGDRLTEVDVRLFPTIIRFDPVYVQHFKCNLRDIRSGYPAIHRWMRHLYWNVPAFRETTNFLHIKKHYTCSHPQINPKGITPLGPVPDILPLDEEVEAVKAAKN
The following text describes a protein:
Function:
Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses.
Subcellular Localization:
Cornified envelope.
Sequence:
MDPQEMVVKNPYAHISIPRAHLRPDLGQQLEVASTCSSSSEMQPLPVGPCAPEPTHLLQPTEVPGPKGAKGNQGAAPIQNQQAWQQPGNPYSSSQRQAGLTYAGPPPAGRGDDIAHHCCCCPCCHCCHCPPFCRCHSCCCCVIS
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVANMEFQGTLPFHPLEDPETLLLKFTDFVHQHSVEQCNQLSMYIIASVNSLAEAFYGSHPEKYNIVFQSVEYAAHSPAISVMHVCYLKELLRQGQYATSLKSFNDLEVSKHIPGSILLQYCMYAAYHCLGNNDLDSAKVWYFSILYIPTTTLTSFHEEAYYSFLLLYIITTGKKFQLDSATSSNVLPLKRHMVPYEEFLDAYLKDVNTLRTVIKEHWSRFLKDNSTAFILFALEVYPMHRLKKWRKTFSSLKLEYIAKQLAISQDVAKEIIQKFDNKTNFTVANGEIFLTFNALDDVSPEMHSDLCQQLIEASKNFEASIRLKSVIYSKIMAKKLNA
The following text describes a protein:
Function:
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Sequence:
MTEIETIGFHYVVEAAGCDPEVLGNADRIRQIFLEAAKVGNMEVKASYFFKFSPTGVSGVVIVAESHISVHTWPEKGYAALDVYTCGTKANPEKAVDYILEQFKAKYAHVSEIKRGIEEDDETFTHMIMTWEEALRKNGNGSG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNPFSEFEHVQIEEVCRICLTKKEQMSLIYETGLADMLLECASLQVTPDNGLFNFVCQQCQNEVSRWYLFKQQVVRSFEVGKWILERRNKKLENDELTNTIKDEVDIPPSVFDVNIAFNTLANNSKDVQSTFLVNESSNQIVNTPTDSQSKKKRTREDLVCKICHKQCLTTNSYNRHIRTHDNSRPFVCSKCDKAFKTTQVLSEHMKRHYDDRRHQCALCSKKFYSKASLNDHLRSHTGEKPFGCEVCGRAFGTKAILRQHLGIHTVREKKHQCNICGKFLLSAGSLDTHVRKHSGIKPFCCPGCDKSFFTKEAMQRHFDAIHDTDNNFLCNFCSKVCSTKVHLNNHLKKKHLGLGKPPNAVCTECGKQCGSAAELKVHVRVHTGERPYKCDICNKRFIAKGNLNSHKWRHTGRKPFLCNHCGKAFGEKSTLKVHERIHTGEQPYKCELCEKAYVQSSALRTHMKGHEKQ
The following text describes a protein:
Function:
Transcriptional regulator.
Sequence:
MAKIVRFGVSIEEDLLENFDKIIEDKGYNSRSEAIRDLIRDYIIKEKWNLKKEKVAGSISLIYEHDVYGLSEKLTDIQHHYHDVIISTLHVHLDEKNCMEVILVRGKVEKIKRLYDELSSLKWVRHTNIAITDII
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSALFDFETVLYVLLLIVCTATYLRQFRPTLYHRDSFELYKKFLYKCSVVGDRLSPWVSVCCLVLAFRIIFVY
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
MPQTHTFEMGMTCGSCANAARRVLEKMGEGITIDSIDVPTKRIVVTTEKSAEEVKTQLEKTGKAVSGVRITHIESH
The following text describes a protein:
Function:
Serine hydrolase of unknown specificity.
Miscellaneous:
MISCELLANEOUS: Present with 14600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTVQIPKLLFLHGFLQNGKVFSEKSSGIRKLLKKANVQCDYIDAPVLLEKKDLPFEMDDEKWQATLDADVNRAWFYHSEISHELDISEGLKSVVDHIKANGPYDGIVGFSQGAALSSIITNKISELVPDHPQFKVSVVISGYSFTEPDPEHPGELRITEKFRDSFAVKPDMKTKMIFIYGASDQAVPSVRSKYLYDIYLKAQNGNKEKVLAYEHPGGHMVPNKKDIIRPIVEQITSSLQEASE
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilization of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MSGTNNVAQARKLVEQLRIEAGIERIKVSKASSELMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL
The following text describes a protein:
Function:
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.
Subcellular Localization:
Late endosome.
Sequence:
MSTDAEQQLLHHARNGNAEEVRQLLETMERNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEHNADTTVVNGNGQTAKEVTHDKEIRNMLEAVERTQQRKLEELLLAAAREGRTAELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLKSGADPNLKNKNDQKPLDLAQGAEMKHVLVGNKIVHKALKRYEGPLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNTYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTVHSFRVPKNSLQQTREDWLEAIEEHSAYSTHYCSQDQVTDDEEDDAVSAVDLKESLEKAQICQQRLDKEISNFLKMIKEGDMAQEMLPSFLQKVEVVAEASRETCVALSDCLHLFTKQEGVRNFKLEQEQEKNKILSEALATLATEHHELEQSLVKGSPPLSIFSEDEFYDALSDSESEGSLSRLEAVTAHSFDEEAEPPSSRQHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEITNHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLRALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSASEESDEMPMPDSESVFVIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWLYSGSYWDRNYFNLPDIY
The following text describes a protein:
Function:
Histone H1-like DNA-binding protein involved in the organization and segregation of kinetoplast DNA (kDNA). The mitochondrial DNA of kinetoplastid protozoa consists of about 5,000 minicircles and 20 to 30 maxicircles. These circular DNAs are held together by catenation into a highly organized compact disk structure referred to as a kinetoplast DNA (kDNA) network. Binds preferentially to a specific fragment of minicircle DNA and is able to compact kDNA networks through DNA charge neutralization and condensation.
Subcellular Localization:
Mitochondrion matrix, kinetoplast.
Sequence:
MLRRSPTLLRVSPFSLYMKDLAKNGTLQNDRNPAKTASRLYRKLSEPEKMALQKRAARVSYPALDAYNRFQKEYAHRFLHLSNKKRQREVSKLWAELKKNGTVKVPKAPKAAKSASSKVKTAAKTAKKTTAARK
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MEPDDDGEFEQLLGEIPRATSAPPHLEELQKAYGGQLDDPLLLMRPDESPVVNPNIDIRSDELYDTFYRSYSGTKKLPPPLPLEDARRGETSGLSPRGLQPQLSPFYSGLDLDSPRFVRSHLSQHGGPSPQHLPQHYHSPHHPPPSHHQRRHSQEHLDSVHGHGHRRHSSQGFLDRDLSLVSSFGGLSMDEGGSSRSGGGTGDSITSGGGASPGDDSRLKLQQLRRSYDAMDGGYQEGFAKNGGGGLSSFGSASSLDGYISRASLGGLDGLGKRVPAADHGFSQRSASVESFQGGGSLEQLLRTRSSPVYDNAGYSRSGKASSSSLEGYPGSGNLDAYVSRLNGAADLYAPQVPPAYLSEYDVAAFLQTQQQMQKAVLQTQRLQQQMEEERLRHRLQQQQLLLQQQALAAAAVQQQRFHQSQMEAAAAAGMPYARSYSPPQRMPSPLHTPPLHKVRSGGGEAGWSGLERAGSICKYYLQGYCSRGDGCPFVHAEPKKEQRGAPAMPHSREEPRYRYGGEKGIPRPASRERLVGNGSNGHHHHGGGEHHLKASPAVHPPLAKYTSLAEVEGKIYQIAKDQHGCRFLQKQFDEGGPGEVEKIFREIIVHVVELMTDPFGNYLIQKLLECCNQEQRQAVLDRVIAAKELVSISLNMHGTRAVQKLIETIAGPDQIRMVVSGLKPGVVTLIKDLNGNHVIQRCLQRLSNDDNQFIFDAAAQHCVEVATHRHGCCVLQRCVDFAEGAQRQRLVAEIAANALVLSQDPFGNYVVQYILDLGLPWASAEVMTRLEGNYPYLATQKFSSNVVEKCLKLAAEDSRNRIVRELMLSPRLGHLLQDPYANYVVQSALTVSKGAVHAGLVDAIRPHLTAVRNSPYGKRILSQANLKLGRGDEGSDGDLRR
The following text describes a protein:
Function:
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (By similarity). Plays a role in cell adhesion, migration, proliferation and differentiation. Has a role in megakaryocytes and platelet formation. Involved in vascular development. May be involved in the mechanism of contact inhibition of cell growth. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (By similarity). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (By similarity). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (By similarity). Enhances the barrier function of epithelial junctions during reassembly (By similarity). Negatively regulates T-cell receptor (TCR) signaling (By similarity). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses. Found at cell borders.
Sequence:
MKPAARETRTPPRSPGLRWALLPLLLLLRQGQVLCAGAAPNPIFDIEAVVSPTSVLLTWKHNDSGASECRIENKMESNLTFPVKNQTSCNITGLSPGTSYTFSIISVTTNETLNKTITTEPWPVSDLHVTSVGVTQARLTWSNANGTASYRMLIEELTTHSSVNISGLKPGTNNSFAFPESNETQADFAVAEEVPDANGTKRIPVTNLSQLHKNSLVSVDPPSGQDPSLTEILLTDLKPDTQYNATIYSQAANGTEGQPRNKVFKTNSTQVSDVRAMNISASSMTLTWKSNYDGSRTSIVYKIHVAGGTHSVNQTVNKTEAIILGLSSSTLYNITVHPFLGQTEGTPGFLQVYTSPDQVSDFRVTNVSTRAIGLAWRSNDSKSFEIFIKQDGGEKHRNASTGNQSYMVEDLKPGTSYHFEIIPRGPDGTEGLSSTVNGSTDPSAVTDIRVVNISTTEMQLEWQNTDDASGYTYHLVLESKSGSIIRTNSSQKWITVGSLTPGTLYNVTIFPEVDQIQGISNSITQYTRPSSVSHIEVNTTTTTAAIRWKNEDAASASYAYSVLILKTGDGSNVTSNFTKDPSILIPELIPGVSYTVKILTQVGDGTTSLVPGWNLFCTEPEPVTSFHCEVVPKEPALVLKWACPFGMYTGFELGVRSDSWDNMTRLENCTSDDDTECRTEVAYLNFSTSYNISIATLSCGKMALPAQNICTTGITDPPTPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAAQPSADVLKYTYEDFKRGASDTYVTYLIRIEEKGQSQGLSEVLNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFTNITYNLQNDGLINGDESYVSFSPYSEAVFLPQDPGVICGAVFGCIFGALAITAVGGFIFWRKKRTDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYTAEIAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEVVLPEWTIRDFVVKNMQNSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQKDSKVDLIYQNTTAMTIYENLEPVSMFGKTNGYIA
The following text describes a protein:
Function:
Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position. The branch chain-length distribution of the reaction products shows degree of polymerization (DP) of 3 to 13, with two local maxima at DP 7 and DP 11. Exhibits an alpha-retaining catalytic mechanism. Is involved in glycogen biosynthesis. Shows a secondary activity, i.e. the hydrolysis of the substrate, being 4% of the total activity. Can use amylose as substrate but not alpha-1,4-linked oligosaccharides of 2-7 glucose residues, beta-cyclodextrin, 6-O-glucosyl-beta-cyclodextrin and 6-O-maltosyl-beta-cyclodextrin. Is not able to branch amylopectin further, it only hydrolyzes amylopectin. Thus, displays preference for linear and long substrates (amylose) over branched structures (amylopectin).
Sequence:
MARFALVLHAHLPYVRAHGMWPFGEETLYEAMAETYLPLIRVLERLRAEGVEAPFTLGITPILAEQLADARIKEGFWAYAKDRLERAQGDYQRYRGTALEASARHQVAFWELTLDHFQRLSGDLVAAFRKAEEGGQVELITSNATHGYSPLLGYDEALWAQIKTGVSTYRRHFAKDPTGFWLPEMAYRPKGPWKPPVEGPPEGVRPGVDELLMRAGIRYTFVDAHLVQGGEPLSPYGEAALGPVESQEATYHVHELESGLRVLARNPETTLQVWSADYGYPGEGLYREFHRKDPLSGLHHWRVTHRKADLAEKAPYDPEAAFAKTEEHARHFVGLLERLAGRHPEGVILSPYDAELFGHWWYEGVAWLEAVLRLLAQNPKVRPVTAREAVQGPAVRTALPEGSWGRGGDHRVWLNEKTLDYWEKVYRAEGAMREAARRGVLPEGVLRQAMRELLLLEASDWPFLMETGQAEAYARERYEEHARAFFHLLKGASPEELRALEERDNPFPEADPRLYLFREA
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MLRRCDADPAALAKYVMALVKKDKTEKELKDICLDQLDVFLQKETKPFVDMLFETLSSKSYLQGKPSLPPRLGAVVPAVAPLIPAIPQPPVMTPATVAAPAQLLVVPAHKESGLASMAAEASLPVVAPAQQGKAPGVTGVRKDEVAEEEREPSRTSHRKSKSRSRSPVGGRSRNRSREDERRSGRRFADERRRRTSERRRHEAGGRHRGDGTRNRWGPEERPGRSAGPRDRSHSGRRSVSRSRSRSPRSRNRSRERGYCMRGDYCPFDHGNDPLIVEDVSVLRFGLSGPPPPPPPPPPAPALPPQPSLPQGVPPSLAQLTQVLPPMAGSQESQALAAAEPYNPEAPGMERPLRRPSHRELIPVGPPPADLSQPPPPTRTVIDPRGPPLGPPPPGMSPTDGVAEGSNGAGVLGGAPGAPPTAPVLPGVPTQGMVGIGGPPPPLHHQGPPPPMRQGRGCPGPWERGPRPPMPNWGPHGMGRGRPDYGRNRAASHYDRCELEVRKVPRNLNTITELNNYFSRFGNIVNLQPTIVSVVTSFDLPQVCYEGDPEAALIRFATHGEANAAYRCTEAVLNNRFIKLFWHNKDRANSNNSAGGSNAPAINGSAATHDGAAAGSNGGAAAATLPPNGSSAVAETLPSKNVKERLGTPLVEKSAVFGAAAGNLSRTVFNPAALKKNNVINTGLPKRTKEEQKKEVIKKKVEVQGQRQRLLEKHLQQNKTLANLDAVIQKLRTDFKMATNELISSRGGRGAVAAAAAFKADVPQGAAGRTQAEKELLDAEMDLYNKVHRGDDTTDLRKRVQELRHQVTGCAILGSFVHSVFRAGPQSATLKLWWSFVDRSMAPDGPFDHRPRKVFVQGMDEGDKENLQAHFAQYGEVEGVERLNTGLVITFKTRKDAELGVSRGSEFKNRPLQWAWFKEQSRTPSAGDSASAPSLAHDDLVADDESTLALEEDLLLVDDEEEEDSEARSWRR
The following text describes a protein:
Function:
Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MISSKSLDYTRFLPFFAALVRGHCLTVKSPTHNCGSGVKTIMDKSSIFLKNRYPISINRFVQQRKTFCGASVCLHKVLVQRQFGFEEKSHGLKYKKLFRRNIGTSEKKNRLPDLLELSSSPRRLPILFAAFCLLWGTCAVLAIQYGKQNSNVTQVVMYRVQHSKEAQDLLGSNIDFKYPFPWVPGKLHKRQGFIDINFEVSGSLASGTVHYQSQRFGPIAHWVELDCTLTSNGKTIKIPTGVSKDTQWT
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity). Involved in osmoadaptation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MGAGSSKPEASAGSKHIFESNSPIQFSSNLVDGLQSNTETDSARAKSLELEIQNRVAKELERLRAREQQTLAEIEKRLSEAKDTGSFASAPSAPAVTHYPAGSLDLDAPRIPFAGREYAPPPPAAVEVAAVNKELNRESVNSEIEELRVKLEGRKKLAELDEGVAKAQKDVVSCLRLNDRRPLDCWKEVAEFKKEVARLEEGFVDRIVG
The following text describes a protein:
Function:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.
Subcellular Localization:
Chromosome. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages.
Sequence:
MDIQPWYLKTSKLALALAIIHSKPADRSSREYTEYLASLVTQKESTWKSKLEALEAEVLQLRQKLLLSRISSGLFKNGPDVLPTLSDQEPTSSENTLTLMDDSGCVLSNEQRNEPAELSQHFVESTDPPLLPLPLEKRPRTTLENPLSSHMQFFQHLLELKKWTESSSLKVYLTHFEKDSSTVSDSVSQLLDALITFYRNPKLPFSSFWTEAVGTLARLASDFNLSNHIFKRCSKKLEEFEKTLLQAILENNSINRFQVQRYVSQSLVTLGSCSLLRKSIISLLLSEVNSFVDDLGAIDQDQGIYDVTRYENIFSLFWILEQVLQQAPQGDRTAHMDHSIPEMQTFLQKHDEVIFRLSDAFPLFAFYLWRLGVLLNSAEMETVKNESLP
The following text describes a protein:
Function:
Mediates the conversion of 2'-dehydrokanamycin A into kanamycin A.
Sequence:
MSSQLALRGPELSANLCKPEEDTLRVLVTGGSGNVGVGVVRALNAARHHVVVASRGYSPALLPEGVRAVRLERTEPDAYTRLVAAEKPDAVIDLTCHDAADAAVTLRACAGVDRVVVVSSVTAAGPATTTPVTEATAAPPLSEYGIDKLAVEETVRAAWADGTSQALLVRLGAVYRLGADLDGQLAEDGCWLAHAAAGAPAVLADDGAARWNLLHADDAGAALAELLANDRARGVLVHLASRHPLPWRELYERVHHALGRPFNPVSVPAEWAAEQLEDAEFLAETSRWDQVFDLGLLDRLAPSYQERGGPSRVTEVALWLIRQGRVGDAELGAEIQELPARLAAVRTAPGLV
The following text describes a protein:
Function:
Modulates seed size by negatively regulating the cellularization of syncytial endosperm. May function by binding and modulating the activity of WRKY10 transcription factor.
Subcellular Localization:
Nucleus. Note=Expressed both in the unfused polar nuclei and in the fused polar nucleus in the central cell before fertilization, in the syncytial endosperm after fertilization and in the endosperm nuclei.
Sequence:
MDRPRQNDHLGVNRIGKNIRKSPLHQSTFAASTSNGAAPRLQTQPQVYNISKNDFRSIVQQLTGSPSRESLPRPPQNNSLRPQNTRLQRIRPSPLTQLNRPAVPLPSMAPPQSHPQFARQPPHQPPFPQTTQQPMMGHRDQFWSNTAESPVSEYMRYLQSSLGDSGPNANQMQPGHEQRPYIPGHEQRPYVPGNEQQPYMPGNEQRPYIPGHEQRSYMPAQSQSQSQPQPQPQPQQHMMPGPQPRMNMQGPLQPNQYLPPPGLVPSPVPHNLPSPRFNAPVPVTPTQPSPMFSQMYGGFPSPRYNGFGPLQSPTSQFLQPSPTGYPNMFSPRSPYPLLSPGVQYPQPLTPNFSFSQIAQQGSLGPGAGPSQGPPQPPPSPGLMFPLSPSGFFPMPSPRWNDY
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKTWPPRTVIRKSGGLRGMRTLESALHRGGLGPVAGVDEVGRGACAGPLVVAACVLGPGRIASLAALDDSKKLSEQAREKLFPLICRYAVAYHVVFIPSAEVDRRGVHVANIEGMRRAVAGLAVRPGYVLSDGFRVPGLPMPSLPVIGGDAAAACIAAASVLAKVSRDRVMVALDADHPGYGFAEHKGYSTPAHSRALARLGPCPQHRYSFINVRRVASGSNTAEVADGQPDPRDGTAQTGEGRWSKSSHPATMRATGRAQGT