lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (By similarity).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.
Sequence:
MSSGPIRTLHKGKAARNRTPYDRIAASKDGNHSNGPQTPSKSIFQRAKEWLTPSSWKKAISIFSSPVVNKHEDSFDSKTDEEYLQNVSTTTEDVSMLINTPVTEKYEQEHRDTSAQATPSIVEQSPNQMLANFFSKKGKTPLNEIEKEGIISILNKSASPSSSVISPAASLNRFQTPRAAAISKRESGVSSEPRARTSSLTPGNTPNSAKQWSAFRSTFSPLREQDQLSTISPNSLLPAQRLSYYGPTLSTPYNRRLRHKRHSTTPISLSNSIAPSLSFQPKKARYESANVSFNDTSFTNVPTSSPLHQSTTANHPEKTPSRAAASLLSILDSKEKNTPSITAKAGSPQSAPSKASYISPYARPGITTSRRRHDQIRPSSEKSEPEKKEPSAFETLEKSSNVQTYKPSLMPEFLEKASTHGSFAKQKEGEQTSLSEKTALSEPENKTPVFSFKAPSATTDKPSPPVSSIFSFNAPSAASTKPSPAVSSTFSFNAPTTTPSATSFSIINKEKPARSPNETIDVDLEEEGSGISAEVEVANEGEDLQKNATEVKASTSEKPVFRFEAVTDEKNSEVSSSNQASSSTMISQPNTGFSFGSFNKPAGQEEKPQQRSLFSASFTTQKPELPAAKIEPEVQMTNVAIDQRSFEQAEKSPISVSESTSLVEVEKPSAEGTNEHKQDATMTLEKTDKQGSLEEEPFPKFSFTVLPKENGENLSTMESTQELPKFSFSVLKEEKN
The following text describes a protein:
Function:
Histone methyltransferase involved in regulation of flowering time. Required for the expression of the SOC1/AGL20 gene. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the SOC1 locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Sequence:
MQFSCDPDQEGDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLNVITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKCEGRGWGLVALEEIKAGQFIMEYCGEVISWKEAKKRAQTYETHGVKDAYIISLNASEAIDATKKGSLARFINHSCRPNCETRKWNVLGEVRVGIFAKESISPRTELAYDYNFEWYGGAKVRCLCGAVACSGFLGAKSRGFQEDTYVWEDGDDRYSVDKIPVYDSAEDELTSEPSKNGESNTNEEKEKDISTENHLESTALNIQQQSDSTPTPMEEDVVTETVKTETSEDMKLLSQNSQEDSSPKTAIVSRVHGNISKIKSESLPKKRGRPFSGGKTKNVAQKHVDIANVVQLLATKEAQDEVLKYEEVKKEAAVRLSSLYDEIRPAIEEHERDSQDSVATSVAEKWIQASCNKLKAEFDLYSSVIKNIASTPIKPQDTKTKVAEAGNEDHIKLLEAK
The following text describes a protein:
Function:
Inhibits a wide variety of beta lactamases.
Subcellular Localization:
Secreted.
Sequence:
MRTVGIGAGVRRLGRAVVMAAAVGGLVLGSAGASNAAGVMTGAKFTQIQFGMTRQQVLDIAGAENCETGGSFGDSIHCRGHAAGDYYAYATFGFTSAAADAKVDSKSQEKLLAPSAPTLTLAKFNQVTVGMTRAQVLATVGQGSCTTWSEYYPAYPSTAGVTLSLSCFDVDGYSSTGFYRGSAHLWFTDGVLQGKRQWDLV
The following text describes a protein:
Function:
Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the NAD-dependent oxidation of UDP-N-acetylglucosaminuronic acid (UDP-D-GlcNAcA) to UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronic acid (UDP-3-oxo-D-GlcNAcA). Cannot use UDP-GlcNAc or UDP-GalNAc as the nucleotide sugar substrate, and can use only poorly UDP-D-glucuronic acid (UDP-GlcA). Undergoes an NAD(+) recycling mechanism using 2-oxoglutarate as an oxidant.
Miscellaneous:
MISCELLANEOUS: Seems to proceed via a ping-pong reaction mechanism.
Sequence:
MKNFALIGAAGYIAPRHMRAIKDTGNCLVSAYDINDSVGIIDSISPQSEFFTEFEFFLDHASNLKRDSATALDYVSICSPNYLHYPHIAAGLRLGCDVICEKPLVPTPEMLDQLAVIERETDKRLYNILQLRHHQAIIALKDKVAREKSPHKYEVDLTYITSRGNWYLKSWKGDPRKSFGVATNIGVHFYDMLHFIFGKLQRNVVHFTSEYKAAGYLEYEQARVRWFLSVDANDLPESVKGKKPTYRSITVNGEEMEFSEGFTDLHTTSYEEILAGRGYGIDDARHCVETVNTIRSAVIVPASDNEGHPFVAALAR
The following text describes a protein:
Function:
Class B beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, cephalosporins and carbapenems. Acts via hydrolysis of the beta-lactam ring. Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities. Has endoribonuclease activity, cleaving substrate RNAs preferentially between U/C and A, in vitro.
Miscellaneous:
MISCELLANEOUS: The class B beta-lactamase family has a specific amino-acid numbering system known as BBL, for standard numbering of class B beta-lactamases. A multiple sequence alignment was used to derive a consensus sequence and then the consensus was numbered taking into account insertions and deletions. This allows use of identical numbers, e.g. for active site residues, despite differences in protein length. UniProt always uses natural numbering of residues, hence there appear to be differences in numbering between this entry and some papers.
Subcellular Localization:
Periplasm.
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
The following text describes a protein:
Function:
Acts in the nervous system to mediate the control of copulatory organs during courtship.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTQTRSGGGGGGGGRNKEAGGGSGGGAAGGNNEKSGGSTGAASGAGAGGASATHTVVKAKQPTAEQIRIAQITDIKSGMDDPKIQEKIQSLMETTQRSEEEVCCALQECDSDLDRAVIFLLETLPVGAFATTSKKKKSKSQAAAQKDGEDGGDWETTGPTTVGGASVQLGGINVDLKEQQRRGGNRGGSGNQRSGGPGRGGRAGGYRDGGGDRDRDRDRNGYDKGGEGGGYRNRAGGDGGRMRGGRDGPGGPGRGNYGSRGGRGGGPRLGTRGPGSRDQNRGSRMMNNDHQEIDSWDPVTTPANANDLKPEDCTAFTDTWGDWDNEEYTGTLADTKGYAGAVASTTAPSAGAGAQQQQSQQSTQTGVPPAASNVTELAAPPGLEQQVLNPPPPKDTELVQQYSTTVVSSTATAAVAAGGATGVASVVPQYSDLHAGTPNATTAAQHLRQALDMPPMNTSSSLSAEQSQYFSTLSSQNSNLQPTPSAVGFQQQPPAGVVASQPPTTVVPAVQQQQQPPQPNSVQYPTAFVGATSDATAAAAAAGAPTSYAAAATQQPPVRRQRARVPPPSKIPSSAVEMPGDNMNNIGYLDVQFGGLDFGADDSFDAVVSDKFNSTTGTAGSSTVQQQQQGAQVPPATVGVQPPAPQSQLQQQQQQVVSQAPQQTPKPSNLPGAPGLASSQIMPGQGTTEALSSQNDGLANSYSRTNASGSVSTSVSAGVNSMSNAAAALDQLTKSDPYGQSASTNTALTGGYQNAPYSSTQANKTASYPPTGAPQGYNNMSYSNNQVTNAYPPSTNNYSSYNQGNVNAYQPPSSSVTNNVVPNNNTGNSVGGVSNQSNLPVNNNAVNSSSNNNAGGYLSSQYPVSQTSSAFPSQQNYQNSSQNVYGNTGLNSNTGVASSTVSNSSTNNSNNNVTSSSSLPISSVVSTTTKSSSTTSGTSVVTNLPMVNPYIQAPGLPFYQQAAVYSYEDLQLMQQRMPHVPGFYDINYQTPTSLGAAGVRDANLGSVAYSTMSDGRFTRTDNNSSPVSNVPSSLSQQTGSGGPMLNLPYAYFYGGNMMPASGFQYGTPVYPQQMPTNAATSGGQFQKPAYNTGGYGSATGYDTLGQSGQDYNKNAYQASIVGQQQSKGQTVANQQSGSGSGSDMAPSMYGKNHVAINKVNYDKQSFHSGTPPPYNIAGTQTAGTTSAQPYGQHLAYIPTMATHHNINMHQNMHQDSNSSGQRPQNNNQGKTASKQQGYSASTYWTGPN
The following text describes a protein:
Function:
Catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate and carbon dioxide with the concomitant reduction of NADP(+). Cannot use NAD(+).
Sequence:
MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAALEAVQG
The following text describes a protein:
Function:
Solute-binding protein that binds 3,4-dihydroxybenzoate and 3-hydroxybenzoate (in vitro). Probably part of a tripartite ATP-independent periplasmic (TRAP) transport system that mediates solute transport into the cytoplasm.
Subcellular Localization:
Periplasm.
Sequence:
MTISFKGLARGVACAALVLAALPAAAKEFRLGLITPPPHTWTKAAEAFGAELSEKSGGAHSVSVFPARQLGNEAQMLQQLQTGALDMAFMTVAEVSNRVPNMGAFYAPYLAGDINHAAAILRSDTARGMLAVLPQEAGVVGVGFGSAGMRQILSRGAVNSAADLSGLKLRITPFDPILDFYNALGAAPTPMPLPAVYDALANGQVDAIDMDVELINVLKYHEHADTILISNHMMFPMVGLISARVYAGMSDADKAMISELMAKHVDSTLDVYMVKEPEWTDALTKVGKTFKRVDQSFFGDAIAQWETIWADKAPSLPELRKTAADLQ
The following text describes a protein:
Function:
Repressor of the glycerol-3-phosphate regulon.
Sequence:
MKQSLRHQKIIKLVEQSGYLSTEELVAALDVSPQTIRRDLNILAELDLIRRHHGGAASPSSAENSDYVDRKQFFSLQKNNIAQEVAKLIPNGASLFIDIGTTPEAVANALLGHEKLRIVTNNLNAAHLLRQNESFDIVMAGGSLRMDGGIIGEATVNFISQFRLDFGILGISAIDADGSLLDYDYHEVQVKRAIIESSRQTLLVADHSKFTRQAIVRLGELSDVEYLFTGDVPEGIVNYLKEQKTKLVLCNGKVR
The following text describes a protein:
Function:
Essential component of the TIM17:23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Links the inner and outer membranes (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MGTPESSREPCPDRILDDVGGAFAMGAVGGSAYHLIRGIYNSPGGARLSGGVQALRMSGPRSGGSFSVWGGLYSTFDCALVYARQKEDPWNSILSGAATGGFLSLRQGLGASARSALVGGVLLAMIEGVGIMLNKVQSTAHNEQFMEDHAATSLPYGMGQISGQSVPVPETSSSSSGSVSWFGSLFKKKKETEDHHSESRTHILESFDAPPVPTYEFK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
Sequence:
MERTLWDISPALSTATPTWPGDTPFSQEIAWKLEGDCPVNVGRITLSPHTGAHADAPLHYHADGAPIGAVPLDAYLGPCRVIHCVGVARVEPEHVRDALDGAPPRVLLRTYARMPQNAWDDHFAAVAPETIGLLAAHGVRLIGTDTASLDPQTSKTMDAHHAVGRHGLAILEGLVLDDVPAGDYELIALPLKFATLDASPVRAVLRRLP
The following text describes a protein:
Function:
Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. Has ribonuclease activity.
Subcellular Localization:
Nucleus, PML body. Nucleus, nucleolus.
Sequence:
MATGSVHSSSGNGRSQAATVVDEFTAPGDKKSLLERSRPRVQALFPVLFTVLGSLETFHQSEVKEDGEKPCRIWLQLKGGKQAVGRAKEYLKGICEPEMEEKQSYPKEMHCIFAGAQGSFLNHLIRDTYANVTVPDIGVLSMKGGTEPVVMAQSRVQQFIRLFNDNVSLPNHKEPAVKKKFKLYVEKHADKYTVDLLLLPSALKSELLSLACDDQLSGEDFSRQSSDDKVESQVNQKDEVSRNGAGTPVTELTSQLDSVFSSVAEDSPCLMERPYSEQDRLSVKRRSSEAEERFSKKPFSLEAVQVDGPVNRNADTNNVPIIDLISEPSDFEDSVILVEADDNVSSETEYKILVNFFKTMGYSQNVVEKVIGDLGQSEEPLKLLEEIEKQSKKELYSHPSSNSTELLKARGTSNLPKCKIAIAEPVQQSAAPLKTQCKALLATDKAGPSNSSHDKSQTKATVANTIPQDQKTTIAPTERPLNKHSDPPLTGVQIFQNSLKVEYRLELKNEPGKLDLKHIIIDGSNVAMSHGLKHFFSCRGIALAVEYFWNKGHRNITVFVPQWRTKRDPYITEQHFLQQLQELGILSFTPSRTVLGARIASHDDRFLLHLAERTGGIIVTNDNFREFVVESPMWREIIKERLLQYTFAGDIFMLPDDPLGRYGPKLDDFLSKQPINRNRTRPRPHYLCDATVHARTYFHH
The following text describes a protein:
Function:
JanA and janB regulate somatic sex differentiation.
Sequence:
MEFAGKFLKPVWRPMMQAARLYCEKPMRSLVAFPVAKVESGKSKYMMAHVYIHGEMGSAKQVIRSLSKAKYHLDVYDELKKEAESMGLCTQGLGGGYLVHDKEKKYIKLYGRSQALGKADHEAAREILQPIYTDHKIDAESGGMEP
The following text describes a protein:
Function:
Probably involved in transport through the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFSEYASKFLSQSQSRLSSFAGQDNNDRPSSRQPGGWTGRGRGLSGRSYYRGATGNPYQPTGSRFGTLAGFGSRYAQDAPLFQAAVEQEEEDEEERDREAADLFALQRSRRVIPAARLEDSTEAEDDGSASLERSRGYQDALGTRLHGIRSSWNDSTSLSKREHDRRQGGSKLFGKHKRQGSDEDDSTKGAMEDVGLQSTIAEDDDDPPEDLLGEASMGSSPPAFQKFKSRPATQRYSTRRSSVQDSEAGLLHESRRSFDGGLPPDAGLTPAQPVADGEIFVHDPFFAYIFLIALASLFATFVLVYLHTSGKRPLGDTIYNTITKSFNLLAVDTLVSMVVAFVWLATLRAYIRPLVYLILVSVPIIMTAFSLYPLILSFRSTSGSTRAQDTVMRWASTVPAAAAVIWIYMVFKGRLAIRSAIHILEFSSRILAANSPLMLVGVGCLATVVLWTWVWLLMFTRVFLGGSFSSYLSRFIISASSWWLGIYFVLMYIWTLSILSGIQRATTAATVSQWYFHRNAVPAASSKDVVSAALGHALSTIFGTISMSTLIALAIRLPLLILPSRAANILSMIVYSFVPTPIAALTNPLTLTYAAIHSESLAVASRGLSRMDFLAPQRPTTTLTPVALRSDTHNSPLLPYRLAKLILHATRFIMATALGFAGWVMTARQLTVERPDGTLGLKGSAYAYVVGMVASFIGWGILGAMEGILSGIVDAVVICYGSERGMASGGYCMEAAQLFGSFNGSYGRGRDEEDRREVY
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MANTIVENIQRIPPVTRFFTLASVMTCLAITSFDALPGLFCNYHTLSNDFAGIYKVYQKGNSFNTAKAIALQVINSYKFLTSTLIPSDVLSSQRWNALMDIYFFYTFSNHLEAYGGKFNGNFPDYLWYAITCGTMVNVFALFYNAFFDPMPIFPHDCLLACLTYTWSRANKNAKINLMGIVPIKAYYLPLGNILIKLILRGPSGLVDTIIGILSGYLYLCIQSNTLPVYNLLPDAYGKNTEQHTDARRVGISRYVDNGGSQYEYIGDSIYDKGYWKAPKFFYNLLGYPSKNSVRTTAFDSTPRNEESATTGYSWFGSGATAFRGKGHRLGS
The following text describes a protein:
Function:
May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular Localization:
Nucleus.
Sequence:
MARVPHVVADAGAFLSGAALQDVAQSVYTVPEVLAEIRDRRARRRLAALPYELQLRRPRADFVRTVTEFAKRTGDFPSLSAADLQVLALTCQLQAETAGPGSVRLQPPDKVRLSSSPRHPEATLHLAGFHLPAKHKRPRKGRQQHGPDSSTELPDNAEFGSFLYWRPPLPSIEDELQEMLKTHSISSSPAATDELQNSEDGDGAEEEEDDEEESDDDNEGWITPSNLKQVQQDTGHCDTVPANVQVGCVTTDFSMQNVLLQMGLHVLAVNGMLIRQARSHILRCHGCFRTTSDMTKVFCPHCGNKTLKKVAVSVSEDGSLHMHFSRNPKVLNPRGLRYPLPAPQGGKHANNPHLVEDQPFPQQRLSRKARQKTNVFDPDYVAGVSPFAENDIYSRAANLQIRDRALGAGRRRLNPNAVTKKFVKRR
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit. Required for pre-rRNA processing and cytokinesis. Associates with the precursors of the 25S and 5.8S rRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MVKSTSKTSTKETVTKQPTEEKPIQEKEELALETSSSSSDEEDEKDEDEIEGLAASDDEQSGTHKIKRLNPKKQANEKKSKDKKTLEEYSGIIYVSRLPHGFHEKELSKYFAQFGDLKEVRLARNKKTGNSRHYGFLEFVNKEDAMIAQESMNNYLLMGHLLQVRVLPKGAKIEKLYKYKKRVLVEKGITKPVKQLKDNMKQKHEERIKKLAKSGIEFKW
The following text describes a protein:
Function:
Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity); Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
Subcellular Localization:
Nucleus.
Sequence:
MSDEEEDSVSEGFSASEDEWKPSKDVKGGESSDDDDSDFDELQAEGGAAGSSGRSSAVAGKRGDHKAPSGIKGSSVKKRKPTGQSLRSKLYNKYRPPPKTFPTSPSQQKENTPRASGSKNAKTPNESGARNQHGPADSSSESSVEDYLVNPADLDLHSTFFAGGQKEKSPAPQFDCNAGITNLSDSGSEDNNESSFEDKAGNAFDFRGLLENANSLERTRDALSKRNVTATPPRSQAATMDVNALLALGENQNYQSVEVEEREGNQRKKAGRGAPAAPPTLDEPSRLSKTKSTRIKRHTKTRPVSTVVANAGDTDDSDFEEVADADLSSDQDDGETPNISGDLEIRVGLEGLRPTKEQKTQHELEMALKRRLNRDIKDRQILLHKVSLMCQIARSLKYNRLLSESDSLMQATLKLLPSRNAYPTERGTELKYLQSFVTWFKTSIKLLSPNLYSAQSPATKEAILEALLEQVKRKEARCKQDMIFIFIALARGMGMHCRLIVNLQPMPLRPAASDLIPIKLRPDDKNKSQTVESERESEDEKPKKDKKAGKPAEKESSKSTISKEAEKKNNAKKAEAKPLSKSTTKGSETTKSGTVPKVKKELSLSSKLVEKSKHQKAYTSSKSDTSFDEKPSTSSSSKCLKEEYSELGLSKKLLKPTLSSKLVLKSKNQSSFSSNKSDTSFEENPSTSSSSKSLKEETAKLSSSKLEDKKVASPAETKTKVQSSLLKRVTTQNISESGDSKKPKVAPVDTFSPVAGRTRRATVKPKTEEKPQVVGSPVIPKLMLSKVKQLNAKHSDTENASPANKHLQEQRNTRETRSRSKSPKVLISPSFLKKKSDGADSTSDPQKHQMAPETKARISPNFLSEALPARQLRSRGQKASSLAIPQLDGGDDVPLPKKRPKLEKLKNSQDSDEVFEPAKPVKKAPVLPKSVQNLRKDRRVMSTDDEGGSRLNRKTDASDMWVEVWSDVEEQWICIDLFKGKLHCVDTIRKNATPGLAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGRRTKRDITEDDQLRRIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSRDCVHLLHSREIWLKSARVVKLGEQPYKVVKARPKWDRLTRTVIKDQPLEIFGYWQTQEYEPPTAENGIVPRNAYGNVELFKDCMLPKKTVHLRLPGLMRICKKLNIDCANAVVGFDFHQGACHPMYDGFIVCEEFREVVTAAWEEDQQVQVLKEQEKYETRVYGNWKKLIKGLLIRERLKKKYNF
The following text describes a protein:
Function:
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.
Subcellular Localization:
Dynein axonemal particle. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
Sequence:
MMPRAGKKLRSQRSPLPEASAHARVGPTPGAGRRGRRSGRRGAVARVSLVMTHIRGGGGSKMAAPMEVAVCTDSAAQLWSCVVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYINAWELQRKDQLQQKIMCPGPVTCLTTSPNGLYVLAGIAESIYLWEVSTGNLLVILSRHYQDISCLQFTGDSSHFLSGGKDCLVLVWSLCSVLQVDPSRTPAPRHVWSRHTLPITDLHCGLGGPLARVATASLDQTVKLWEVSSGELLLSVLFDVGIMAVTMDLAEHHMFCGGSDGSIFQVDLCTWPGQREKSFQPEQDSGKVFRGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCVRTVTLKGPVTNASIMLAPISMLSSDFRPSLPLPHFNKHLLGAEHGDEPHRGGLTLRLGLHQQGSEPSYLQRAEQLHAVMCGTMEKNVLGGQEQLRVRVTELEDEVRNLRKINRDLFDFSTRIITRPAK
The following text describes a protein:
Function:
May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Sequence:
MAAKARALAVYVHWPFCSRICTYCDFVKYPAIKQPAWFRGAGRGADPTHDEVLQAYRRQLTQLVQQLPSPNTQRQLTSLYFGGGTPSLMSPSLLRRLVDLVYTMFPPSSHPVEITLEANPDNITRDTLARWQTAGINRLSIGVQAIRDPLLQALGRQHSAEVALRVVKQAQDVFGSTGVSLDLMFGLPGQALDDWCTDLDHVLTELKPAHMSIYELTVKRGTILYHQTKLGLKVPDPDDYYFATQDICSAHGLERYEVSNYAQSPTMFSRHNMAYWRGTDYLGIGPGAVTSTIDLVSRQLVLCYQAKSMYLAVPSPFKRQPVLRYQQVHTCLLTLRDGDGCMATLRQRWRLDGMDQALIKRTMEEAVTDIVAFLCRTREPFDLAQVAAHFGVSLQPKARKELQQLAQAGLLEYSEKIQPTAWASRFNQPITEAGHLPASIRLTGKGLDVCNRLSTTVAELLLV
The following text describes a protein:
Function:
Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGRGKKKESGSDESVLFRAPSPSSARTRPGLGSQRSWVLIPTKLCQLTRKITMMIRVCKMFRQGLRGFREYQIMEETHCKASVFTTSSKKQGPLLFNYKDFKSQKGHFPPRAIEITKKIPAWRQEAELRMLCNLLQVIESFRTYSERLQELLAKVIRFERFGRRRVIVKKGHPGHSFYFIYRGKVAVTDDEDGSSAFLDLHPTMLHQGASFGEVALLSRVLRIATVVCMDETELLVVDREDFFANRLDEELQAEFQQRFDFFRNMDLFRTWPDELLQALSRQCKVEKYRFGQVICQDITQSGNALFIRQGHCDVLRLVDLPTCPSYYKWIWQHLQYQKHSKMDHKTLGKPAGPASRRGHGRSTQPALCLHLPSPNPVPGRKRHPPSFPTSPPIPSYKGVVTTEFGKLPVEAAVGAYIRVQGVDEGEVLGLHQILLPEGLQDKRPLILVSQGAEVIQLKINKLEGFLDRETNEKLTQMQIPYPSDDEICQRFLRENDWRIFHRDLKHLLVKPGETHCPRCLTADHCVAQAGVLNLRAPKGRARRPCSIFISTTSDHREQLPPLRLIHSISAPRPRLQELLPQYRHPGILMES
The following text describes a protein:
Function:
Part of the class C core vacuole/endosome tethering (CORVET) complex involved in endo-lysosomal vesicle trafficking and lysosome biogenesis by facilitating docking and fusion of endosomal vesicles. The CORVET complex acts upstream of the homotypic fusion and vacuole protein sorting (HOPS) tethering complex but is not involved in autophagic flux. The CORVET complex may cooperate with the early endosomal tether Rbsn-5 to mediate endosomal fusion. As part of the CORVET complex recruited to endosomes by activated GTP-bound Rab5. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis.
Subcellular Localization:
Early endosome. Note=Localization to the early endosome is dependent on Rab5 and class C core vacuole/endosome tethering (CORVET) complex subunits dor/Vps18, car/Vps33A and Vps16A.
Sequence:
MSELKAPSLQSLLESERGSTDSLLAESLQLDFEDLDDAEFAIPPTDVLPTLEAVLSEFEADSDVASEFGMPVPHATPTPSIGEDSTIRTDGRGGGGSIMRYTLLHGISAQLSSAAERVNAGAASSCAVAAFIAIGTSHGHILNFDVTQTLRWAHQDKHGQGAVASLAFNADSTRLLAGFSRGLVAMLDTHTGDVLRELFDVITPNTGVLHVKWTSRSSLALCADAGGSVWSLSFTRKLGIRGCQSRCLFSGARGEVCAVEPLIMDSQGRHELDQYCIVALATLSKYFIVTVRPRLRVIKYHVLQGPPDCLPLLAWHLVLIQAADTSRSVDPVIVVGRGNQLFFHQLFVSNGRITLLYLRHVQLQGSLLSAHWLGPKCVASLDTAEILHLVDVRSSKELECMDMANAGLVYGSAQFKGLATGGNVSPAFALAGSNACYNSVVSRGTQLYVLGARSLHIIGVRTWSERISFLVKHHRWQEACQLALDGYIASVDRPRKRAQAKERIIMLFKEYIANSARAPEYCLGAIVNCLITVGELDLLWTQLWEKLHNSSTELFLQHISEHIEKETIHSVNPVISQALVDYWLEHSPAKLEQLILKLDWMCLDLNQVLKAVKKHRLFRAQIYLNTQALNDYTAALTELLPLVTPDETDLGNCLLVYVSSCLAGREYPSGEIPVELVHQVKHDVLRCLTSQHSKENAGDELPYPYLRALLKFDTRETLNVISLAFQEREFSNELGISHRKRIINLLLEIMSPENATWAEIGCLLNFIAQQISMQCLPRDRQLLERVLSHLAQEEIANESSRQHSERENAWHELLSSNCLAEISSDEEQLRLAEKAKCYCVVEYLLEKLERYDTILDSYIRNEARHETMFAYMERHVASPKRSIFRQLKRNLRELLTINAKETTRLLSLHYPEKINELLDNLRREENLLYLFLKCLNDRKSELEASQMELLLELYCKMESSSTVEEFLRSNSGYRLENAIAIAESHHLNRSVIYLYEKQESYAKAFELSMELLKSAAGEEAAKEAQTISALLARSVETLPAQELERCWFALLQYILPHQELQSITKSLLHEASQHIDLHNLVQLIMNTHNVSTSFGDIKDLLMGMLDSSRHKTEALRASAGALCQDLHLKFVKRYQHAHRGLWVTTTKCSMCRQRLYDHSQVLIFGGCGHGIHEQCMEESETQFEECPRCFTAIPDQSIGLPRPNKNLISISSSLEMGALQLKAPPRRFI
The following text describes a protein:
Function:
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also belongs to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Required for pollen and ovule development, especially during the transition from microspore to the bicellular stage in pollen development. Involved in the accumulation of QRT1 and QRT3.
Subcellular Localization:
Nucleus.
Sequence:
MYLYSLTLQRPGGVVCATNGNFVGGKTQEIVVARGKTLDLLRPDESGKLQTLLSVEVFGAIRSLAQFRLTGSQKDYVVVGSDSGRLVILEYSRERNVFHKVHQETFGKSGCRRIVPGQFLAVDPKGRAAMVAACEKQKLVYVLNRDAAARLTISSPLEAHKSHTITYSVTGVDCGFDNPVFAAIELDYSEADIDPTGQAAADAQKHLTFYELDLGLNHVSRKWSEPVDNGANLLVTVPGGGDGPSGVLVCAENFVIYKNQGHPDVRAVIPRRADLPAERGVLVVSAATHRQKSMFFFLLQTEYGDIFRVTLEHEGDRVTELKIKYFDTIPVTSSMSVLKTGFLFAASEFGNHALYQFQAIGEAEDVEASSATLMETEEGFQPVFFQPRGLKNLVRIDQVESLMPIMDMRVMNLFEEETPQVFTLCGRGPRSSLRILRPGLAINEMAVSQLPGTPSAVWTVKKNVNDEFDAYIVVSFVNATLVLSIGETIEEVSDSGFLDTTPSLSVSLLGDDSLMQVHPNGIRHIREDGRINEWKTPGKKTIVKVGLNRLQVVIALSGGELIYFEMDMTGQLMEVEKHEMPGDVACLDIAPVPEGRHRSRFLAVGSYDNTIRILSLDPDDCMQILSVQSVSSPPESLLLLEVQASTGGEDGADHPASVFLNAGLQNGVLFRTVVDMVTGQLSDTRSRFLGLRAPKLFSATVRGRQAMLCLSSRPWLGYIHQGHFLLTPLSYETLEYAASFSSDQCAEGVVAVAGEALRIFTIERLGETFNETVVPLRYTPRKFVLQPRCKHLVIIESDQGAFTAEEREAARKECLEAAKMGENGNANNRQQMENGGGAGDDDEDDALSDEQYGYPKAESDKWVSCIRVLDPRTGNTTCLLELQENEAAFSLCTVNFHDKEYGTLLAVGTAKGLQFWPKRSLAAGFIHIYRFVEEGKSLELVHKTQVEGVPLTLCQYQGRLLAGIGSVLRLYDLGKRRLLRKCENKLFPNTIVSMHTYRDRIYVGDIQESFHYCKYRRDENQLYIFADDSVPRWLTASHHIDFDTMAGADKFGNIYFVRLPQDLSDEIEEDPTGGKIKWEQGKLNGAPNKMEEIVQFHVGDVVTCLQKASLIPGGGECVIYGTVMGSLGALLPFTSREDVDFFSHLEMHMRQEHPPLCGRDHMAFRSAYFPVKDVIDGDLCEQFPTLPPDLQRKIADELDRTPGEILKKLEDVRNKII
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDFPGHFDQIFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDSSMNMIQLDSEVVTAEAFAALVDMMYTSTLMLGESNVMDVLLAASHLHLNAVVKACKHYLTTRTLPMSPPGERPPPEQQQQPASSRLQRSFLLQQLGLSLVRKWCRVPVKRSVSSCVKLVWQETGAGISEAPYGGPQEDAQMPSQSDSGRAGSGPRPQPQAGQGAGDDFRDPQQELPGDGGKEKEAEEEEHMRVVVKSEPLSSPEPQDETSDVTSQAEGSDQVEPGADKIELSPESSDRSFSDPQSSTDRVGDMHLLEGNDNLDTKQAFSISSFLAKGYAGPGQGSASLTDDNLPNTTSAECRIEGEATYLLSPEPINGGSSSGGSLLHHHPASSSHHHHHHHLSGEVNPFGESDGHFLRPMQEGLGYRGGEQFALDFQRSSLGLHSFCRSGRGGGASANLGFPGYRRIAPKMSPAVGGSLRMEGTQLQDACGGPHLLLNGAAGGGSGYEGGPHGAAAGGAGAAAPPQLTRASADVLSKCKKALSEHNVLVVEGARKYACKICCKTFLTLTDCKKHIRVHTGEKPYACLKCGKRFSQSSHLYKHSKTTCLRWQNSNLPNTLL
The following text describes a protein:
Function:
Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MREPLVRGSREAGGQELRTACPRPQEHSRARPPCTTNGSAWSCAPSTPSTTSCSSSSSPRRLPTRSARAPAPARAPSSPRRSLGRQSLLQLSPDSRLNPHRSLLGTGNYDVNVIMAALQGLGLAAVWWDRRRSLSQLALPQVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRTFLAAALAQGLCEVLLVVTKEVEEKGGWLRTD