lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Mitochondrion. Nucleus. Chromosome.
Sequence:
LDSGDIINLVPNQESAEPCTVIDGKTNLLVHHPDTLISGTTVSNSLGCLRRAVLSERFKNTEIATDPNNVSSVMLVGTIVHYIFQTAIKLKPPVAKEILLNVAKDAVYSRKYFADMLAMNTDPKAVLTQVENYLPQIESWIKDFRVGKPCAGNTVNFQLPTSAAPNRFKPVRGSTLRYDANVALTEVKDIEENVWSPRYGLKGKIDLTGNFKITDKKTRTTENTVLPLELKTGKDSHSMEHHVQVIIYTMFCNERRNKHGVPLISLPAGLLLYLKNLKTSCVPLKPVDSSGLMMLRNKVAHSITKTIMKSNANSFEEFSTQSFPPTIDNDRTCRNCSQLRNCALVYKTVDESQGRYRPSSELFIMMSQLFSHLTDADLAYFRHWMTCTFLEEQAANKKDKQKRFWLKTPQERFDEGKCITGLKLGGSSVPKPELADIFFNFRSDNGKENMFKVGDLVLVNGNEPSHIAIATGTIHSINKSFISIITDRDFSGYDSDMIYSIDNHIWLGAISTQSSLSNLSLLMSNETQCNKLRHLIIMHRDPFFAKNLDFIPRSSKNEIAQMLRGLNKTQRQAIKRVLISKDYTLVVGMPGSGKTTTIVAMIRILLLCGLRVLVTSYTHSAVDNLLLKLIKYKTRFLRLGRPNQVHPNVLPYTEAVLSQNLKSPTELQKLYDEYRVVGCTCLSVTSHIFFAIPGQNRPIFDVCIVDEASQIAQPACLAPLFHSERFVLVGDHLQLPPLVVSQEAKKMGADESLFRRLTSHKPALCELTLQYRMNKEIMALSNHVTYEGRLECAHPTVAEATVKLDNYDLVKSMLPDTDIEWLLRTIDPKTSVIFLDTSKREAYESEVEHGIQNMYEATIVTTIAQWLIKAGCSPSKIGIIAPFRKQLRAIEEKYLTENTTLVEINTVDKYQGRDKSVILLSFVRSKKEPLAEKKGELLNDWRRLNVGITRAKHKLVMVGCTRSLLEYEPCKKIIEYVQSNSLL
The following text describes a protein:
Function:
Transcription factor involved in the negative regulation of flowering. May be involved in the repression of the flowering factor GI and HD1 by interacting with PIL13 and PIL15 and competing with PRR1. Possesses transactivation activity in yeast.
Miscellaneous:
MISCELLANEOUS: The gain-of-function mutant A654 (T-DNA tagging) exhibit late flowering phenotype under short day (SD) and long day (LD) conditions.
Subcellular Localization:
Nucleus.
Sequence:
MYMDAFGWSAPAAPCQPSCGPGGDDDDDVLLAAVLGASFELHSLVDGGGNGAAGAVRSDDAYGLDVDLPSHQMSLLRCQDGLSALHGDASPTAAAAAFLDSVDVLPVPAIAGATHDDGGLLDRFAFPNVAETTTVQAAASNTAFSGYSSNTTGGGNISSGESNTYTEVASTPCAVSTTTTTTALPPSKRKLPEKYPVVGTSPTTKTTTTSETAAERRSTKRGAGGSSSITFGGGCHGAGAAAALLGYGRGYEPDTEAIAQVKEMIYRAAAMRPVTLGGPASASDPSSRPPPPPQRPRRKNVRISSDPQTVAARLRRERVSERLRVLQRLVPGGSKMDTATMLDEAASYLKFLKSQLEALETLGNGNGNGNLLHHGYYTGSRNATATAATGSSNSTVLAFGRDGLAGFVKSNRNLQL
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MEADLQSAIDNPTPWFSLLHYPSRAAWRSTDHLLGSPGIKSTLVDDTGMRRDVPTSTQPSPLSQTQFNLIQHSQRTNKQLKRTYKRIMETHNSFATKRERERRMAANFASQPKQHVGPAGSIEDTEGRHVGSWKERKMKPQSVLVCDDPSVSYILSMGMGRPTDRNVDPTAATVEDLNATNASGKPSGKLMASSSKDKPVGYCAEQTLTSFRYRFGPNCSITKRVLLEVQSLLGGAGGPASMRSTFQPKRVLDFGSGIGSSSAAALDVFGVSRSGTDTIVNGIDWIHSIDASQSMREATEKVLTSVLEGVPWGYDQQQLEKDIVDEELVHYEKILREIKGEDDEKALERRRRRLQKWEQSWQKLSNHRTRLTFGESLVDSSSFYSSQIDRDERPSLPWQQQLDDQRKKSQAKKQTSSQKGTFDLILCTYTLSELSSVSSSLTAAALLWEKLSPGGVMVFVEPGTPDGFSTLRSVRSMLLECSPPKEIRERRKREEKKILMDQIAKLDEDDAAIDILTASLEELEIGNNVVQDECHVIAPCTHNGSCPMSRHEKNHVKKNTRFGKYKSSAEDEDNDSTNQDDAAVDTSDEEEALMKELLKEDITQADLEEMLKLMESGMDEDDEGEDDDWGSDEQDTDDDVDFDAYYEVKDAAKSSKSVSSTMEETDVFDSAFCSFVHNFPGGTSRRKGEKFSYLVVQKRDSTNDDTSISRSSTAEDTLGNFDVVELLAKSIHHAQQIKEEVLQKGRHSGQYDTATSGTISHHEEQSQRVLQRAVAIEDEYLDSTIDKLGLELLHGDSRRKGWGRLIRAPLKRKGHVLIDYCSTGCSGCDGKPVGGTKGRIIRQKVSRGWSARVAPGCYSAARKARWGGLWPDTSERVKNIGRS
The following text describes a protein:
Function:
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc-6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransferase activity is weak.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MVGGGRTGIHLLLGFLIGAALALFFFSSTPSIDLTSSLAAFTSCQNQETETNVLEPSALEKGRVYKDLSEHWIVHQDDMPAPPHNQDATPKVTRTRFAATELGTRERVMAAVMAESALALSINATLGRHVPRVHLFADSSRIDNDLAQLTNLSPYKLNGQKTHSMVLGLLFNMTVHNNYDWFLLAKDSTYINPFVLLRMIDTMNWNEPVVMGEAAEDGSGRCRLDTGMLLSQPAMHALMNNRNACNNFALAADDDQLAFEKCIQIATNLTCKPLHQGVRYEVWRGAERADSPAAHDSIEDWKHSPAFKRALAVPRLLSDADASALHDYFVRVEMQRADREIIKMEAELSRLAEQEARETGEAISWPPALPPYAKPPNRYQVSTWEYFTMTELFRSEPNQNVRRLEGKDFDDVAEVVVAARQQVESEEPELEFVQLRNGYRVFDPRRGMDYMVDLTYRKTVNEMPEVDNRFESDNEAAHEESLKEIVVERRVHVSRMIASTQLMNQAPYVKEDTDVTVVIPVASEKDVLPARKLLARQARLCLFPTEEARKTRMVVAVFPLIESRSVTAITNDMEELKRRCKRSLLETDVLPVHPAVSTEGKGTAAAAALDDAVDRYGANTIYLLLSPHADVQKEFFDRARINTIKHYQVFFPVPFVEYHPTISGMEMTEKEEKETPTEQAREAALSRLRDGVEPKRKRTLIVQKEHGRFDSQDFSCFAVYGVDYVTARAKFGQNERRNDLISAFLGQDSIHVLRAVEPTLRIRYHKRSCDMESIDTEDIARCLDSKKENVAAKDQLAKLLFHEK
The following text describes a protein:
Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts (By similarity). Regulates gene expression through activation of NF-kappa-B.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSILLKAAGLLFLGMLQAFPKDRPLDTTCTGDLSYYPGEAARNCCYQCPSGLSPTQPCPQGPATARSSVILTTTNEDRKCTACVTCLPGLVEKAPCSGNSPRICECQPGMYCSTPAVNSCARCSEKTVVKFPDTAEKNTICDLPSPGSGPNGSNPDDCKTLTSHTTPQAIPTLESPANDSVRSLLPKQVTDFVNEGATKLVKVPESSSSKASMPSPDPGNAEMNMTLKLPPPGTVPDISTSENSMEPASTASTLSLLVDARTSSRMQPTSPLSTGTPFLDPGSMLFWVAMVVLLVGSASFLLCYWKACRRRFQRKFHLNYLQQTFQPKMEQVDSCPTEKLTQLQRSGSVTDSSAGHTLSPLSPPAVETGASVGTACLETLPLLDDSITGNSFAPREPPEPRVSTEHTNNRIEKIYIMKADTVIVGSVKTEVPEGRAPVGSTESELEAELEVDHTPHYPEQETEPPLGSCTEVMFSVEEGGKEDHEPTTVSEK
The following text describes a protein:
Function:
Probable GTP-binding protein involved in generating and maintaining the structure of the tubular endoplasmic reticulum network.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEKGVEKTQIIDYDGNVIEDLKEWMIDNKLNDLGFSYNVIAVLGSQSSGKSTLLNNLFKTSFDVMNTKQGHSQTTKGLWLSYDKFDDETNNSSSFFKLKKKNKPTLILDVEGTDSKERGDNRLTFEHRSALFCLALADCVIVNLWYHSLGNFTASNYGLLKTVMEVNLELFQQEKNSPKTILLFTVRDWFEEFAPIEVVRNKILDEYINKIWKEMKKPKEAEKLNINNFFIIEVVGLSHGIIKKEDFLKDVNNLRDKWINNLRPSKYSRNIPSDGFAQYCNNIWNTIVKQSQLDIPSQKEMLSTFRCQEIKNNVINNINKEIKEKSIESHNKVIENFKEWAEKNIIQKCLDDYFKDASRYKENICLRTSQELLDYLFTQLQAIVDNNLQYIQRTLCTKFFNELSNMYKICTIEKNTFSFSRDSNLKTVKDNNKNTSHEDIKRDLLNNNQDKCVHLWSNFLYNADKLEYFTFCNFYENYEKSNIEIKTNMKNDDNLKNDDNLKNDAHNNITTHQFNYKPTLSVLSTSIYKDSNRIRNIQCGILLNKTRQTIKNSFKNMDTYLLTTKNTEEYWNNTVQLVLKLQDNINTHLTKCFINLKGTNHNNLNIYNDDMMYNNDDMVFNNNDDDDNNNNNNNNNYYYYNKNDDANLSKDENYNNKFSFSLTNEKGIFQNINNNNEGSDEICYTNALKKIDLIKNKQVYKSTINEDINNKLQNKKYIHELKNYYLDEIMDVLKNKLDEISENLATIIIQRFESVFNYDEYEQPRQWRDISMAELKKIFLKSKNYAFLIIDILQKNIKVELIDDYLPNNFIKDEIIEKGKIKAKRRIQEICRDAQYIQETGSKMSLKNVPVVFWIILLLFGWNEILFFIRMFFKLNVILPLFFAAAFIVSTFVYNGNTQALSYINKIIFYMAKNSYNFFKHIQAISNPPPKNVQKQE
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MKCSLLLNFLILLLYTFFNSFLSIKFMTNYKDNFSNISNIKKNNYNILKFFYILPEQVRKKYISYFILSCSDKENIKRRGKRIKKDNMEYNKYDIKEDVKKNDMCDITNDDDVISNKNHFINKSNSKLYILITSPEAARIYRYIVILLIHNLKNTNLKYETCNERKLNYIKKFVKDISILSIGHSCNDILKNKFNKSLFYNISNKNSSIHKSPIFKIKKKKLLQINRDISTHLNIVFTPTKANGNTFKKELRDFFFLKKNEQRNNNIYKKDKQKRNVNINQHEYINEQKNLHNNILWISSSISTSSFDDLDIHPQNNNHIYDRINLKRINCYDTQQVTYNINDKTNKIHITKYSIICLMSTSTVLSFYKNFGNNFSYVVCMGKSSYELLKKLNFKNIYFPENSKTKTLLNILITLYHKLNNKYKRKFHIILTRQKDKNEEIKKVLSQQNIDIQEIPCIKTKYNFANISKLYKLLYSYINQACTQRKRTKMIKYI
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTKSTVLSSYKLFAFIFIFRLANSFAIETFFQADEFFQALEPAHHFVYGYGYLTWEWKQQLRSAIHPLIYVLGYKLVGDNTTLVCISPKVINALIAAIGEYNLYKFIIVYDSEKLAWITLMLSLFNPFNWYVITRSFSNNLEMVFTVLALRFWPWNKKINGRWYISLGFGFVSCIIRPTNILIWIPLGIWLLISIRITLKWVALSFLEVVLILLINTALDYYFYQKLTFPLYNFLEFNVFKNLSIFYGTAPWHFYIFQAIPLMLMLYLPLMIYGLKKNILLLTGLFYIIGFSLIQHKEFRFIYPIHPILLYFTARGYVKFKPKFVLIGILLNICIGLFFTNVHERGVIDLTKYLATQQTPSVGFITPCHSTPWQSYFHNPNLDTNSWFLACEPPLHLNKPSMEEIRHYRDQSDQFYDAPESFLQTHLGKDLPKTEQLVVFEPLEPLMNDYLGREYYECQRFYNSFFHWDSRRDGDIIVYCRN
The following text describes a protein:
Function:
May play a role in cellular stress response.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSKPFTPEEARRIVQVLQKPAVFLNMTTDWPALHWTVEHLSACLTKRIRFRVGKRSEDMAPLFETECSYVEATIKEFLSWTANDGEPLVGPFLDYHCKEFWAYADYKYIAQLFQDKPAMFQDVVWSDFGFPGRDGRDSTLWIGTQCANTPCHLDSYGCNLVFQIQGRKRWHLFPPDDTACLYPTRVPYEESSVFSHVNVIRPDLKKFPAYGRARLYTVTLQPGQVLFVPRHWWHYVESVDPVTVSVNSWIEMDMDDEARVAEALTKTIVCAVKSSPSLDNSDQWLNPTEDGVSSHDENMQYLNLAVKVCMNKKRDDIEDQPKAEAVKRDFSGVLKSPASPPSLVSFGPHLIPVHLTEKPQCSSTKDSCCFSCTDSPQCQITTKDQDKLRSDNKLGQRSGQSVLQDTENPGGSGEMHISTNDVLECLVHPDVIALVTRLIMCRQRELHS
The following text describes a protein:
Function:
Global regulator that is part of the nutrient-sensing system. In the absence of glucosamine 6-P (GlcN6P), represses the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Also regulates the expression of the ABC transporters DasABC and NgcEFG, which are involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Binds to the DNA consensus sequence 5'-ACTGGTCTAGACCACT-3'.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTDVSSAENEGGATVRTARVPKYYRLKKHLLDMTRTQTPGTPVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSQDRTGQPVEWVRSVYRGDRYKFVARLKRPQD
The following text describes a protein:
Function:
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation.
Subcellular Localization:
Cell projection, cilium. Cytoplasm. Note=Localizes inside the primary cilium but not at centriolar satellites.
Sequence:
MLKAAAKRPELSGKNTISNNSDMAEVKSMFREVLPKQGPLFVEDIMTMVLCKPKLLPLKSLTLEKLEKMHQAAQNTIRQQEMAEKDQRQITH
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle progression.
Subcellular Localization:
Nucleus.
Sequence:
MDEFVTAEDLVHEYSVLQEPDSVVNWSRYIAAKRDDPCSVSWVYERCLQALPAQWEVWREYLQFRMRLLDGVCAVQHAAEFEKVNRLFWRCVEHNAAVVEAWRLFLGHAQRQGALALVRQVVDAALRGVGLAKHRTVWEDVVAYIEELLPAEETDLGEEQDLHELVRGALFGGAGAEDAGADIWSSAMLRRYIQVAEDAEAVLALLQRTHDYATVVAVYEKHVLPVTRAKHKGRQSYESQFRYLVALDHTGATAKLEDAVARCAQLFPERAPSLTIFLAKHYVKQGNYNRCTDVLTDSLKHTAKSSEFASLYDFLVVFEESLIEVVLEHLQEHPENEERWGADLERHTDQLDGLLADHALLLNDLKLRQEPDNVKHWLDRVELFDKAASKASVYADAIASINYKSQTVPGQLGTLWWQYAQLYIDDGQYETAKTILDKALNVPYNFLQDPELIWTKWAEEELKRAGLDAAMQVLSHALQIPDDHELLRDKFESHEKMPAQTVIFSSLKLWSFYIDLLEASSESDEHLERTKAAYEATIQLKIATPLLFVNYAHYLQDKGNHVESFSIYERAVDIFPAETAFEIWDIYIGEALKYGLPKEQIRDLFESSLKMANEGVECKPFFLLYAKFERDNGMIETAANILHRACRAAQTMDAKRSLWTLCLNWCRQELGGSYARALYEECIQALPNHVAVVYVLEYAKVEEGLKQVKRARALLQYGARLLHPANNADLWEYWELFELRHGNKDTYKDMLQLKRKVEELLEGDGLPVPNQIGNIAFVASTDGLQNPGGESTNINNDELELDM
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP from ATP and GTP and plays a key role in antiviral innate immunity. Directly binds some unknown nucleic acid, activating the nucleotidyltransferase activity, leading to synthesis of both 3',2'-cGAMP and 2',3'-cGAMP second messengers. 3',2'-cGAMP and 2',3'-cGAMP bind to and activate Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish).
Sequence:
MKESRNLENFVEKKLYECKKKYVDIPKDEGQRYGGKHYEALTSKIFEILRKENPELDIIIAEFSLEGSVGMLKIAKPNEFDLVFKLKFPYYKSIAVTRDPKIPGNVLLDMTRVLELLKDDPREDFQRIRELIQGRLVDAQNFFVVDRLRSWLQSLFSQALNRISYRVELVAGVVSHLKYRTCGPAHTIYVYGDYEYSVDYVPAICLAAEQNVLPTKQLECFKRANTSYWEAIPKPLKPLTETSMISFRSSFYAVEKILLQDVHENCRNAIRFMKKFRDVKTNLGNCKSYYIKTLFLWKIIQEPESYWLNPLSFILADMFDDLAENLRRGVITFFWDPELNMIDALTRDQVWEMYLCVQRIPRDLRGAEISRNKWSFFVLREFSHKKERNVNLKCSSRRKRNVIKGLKTTSICKLRNARTNGTWTAGLWTRPGHAYRGPSETVSTWDTVKDAAWSEGIVE
The following text describes a protein:
Function:
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MRATWEPWALYAFLTMGGFGAASGMINWLQHKREYDGAVTNTVGIALGIALSIVALVPIDIYLVSSTSNIAIGAKHAWATSIAVLEITSTIKILYYILFGMLALICFGVLPFMYFYSDDKNNLDDLYSTPLHKAFALSAVPAGILVVLMLIGAYMRLPPILPTNTPWFNSLLVQNGYETGISFIIGIISFVGLIVMVTHVAYGLSHAGLFLIHQKRKELDDIDVIGSLNNVRSCIDALHQKYPGSNAERRMKAQDRRKLQSLQSEQRYLENRLTTRIPAVDTDNDSLKTIQQSAEASCDIFNFAVGGVLLLAMAIVFVISIMATLIDHALRSCGAQCSFLVTTFGTVTILDAMLYAGLNMFSIDVVLVLVLAYYMIGCIFYMMKQYGVGVVGFSLYSLAPGSTLPQALVLFTSAAIVSVPAWIYLMIIAAPQYMAFGAQTVCNVMDSTGKRNCTLTPAQLYSCQFTSPVDVCTPSIISTLVSRYLYTLPLFGTGFYSVSWIFCIVVCIGVVMTVWSPQKKPLDQEHAHLITNASTVSRR
The following text describes a protein:
Function:
Required for sperm motility and therefore male fertility, via positive regulation of spermatozoa fibrous sheath formation.
Subcellular Localization:
Cell projection, cilium, flagellum. Lipid droplet. Note=Expressed in the sperm mitochondrial sheath.
Sequence:
MATSRLPAVPEETTILMAKEELEALRTAFESGDIPQAASRLRELLANSETTRLEVGVTGESGAGKSSLINALRGLGAEDPGAALTGVVETTMQPSPYPHPQFPDVTLWDLPGAGSPGCSADKYLKQVDFGRYDFFLLVSPRRCGAVELPPSLLRSCARGRSFTLCAPRWTRIWRPPAARGPRVSARLQLLQEIRDHCTERLRVAGVNDPRIFLVSNLSPTRYDFPMLVTTWEHDLPAHRRHAGLLSLPDISLEALQKKKDMLQEQVLKTALVSGVIQALPVPGLAAAYDDALLIRSLRGYHRSFGLDDDSLAKLAEQVGKQAGDLRSVIRSPLANEVSPETVLRLYSQSSDGAMRVARAFERGIPVSARWWPGVSASARSTPCSRAVSMRWLRTPNASASKPWRKMSPRGVR
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLESKQFLTELTGLFQKCRMLGSVYITLKKYDGRTKPIPKKGSVEGFEPSDNKCLLRAIDGKKKMSTVVNSKEMAYSNLLRANMDGLRRGTKRPAQDLP
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome. Note=Localizes to phagocytic cups and to phagosomes after their separation from the cell membrane.
Sequence:
MSWQSYVDSFLVGAGKGMGGAIIGLQGGVWAASANCTPSAQESVAIGTACASNIAGLQQTGVVIGGKKYMITRVDADEGTAMGKKGAEGISIYKTKQAVIIGYFSDASVSAGQNSDATYKCAKYLMDAGY
The following text describes a protein:
Function:
In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.
Subcellular Localization:
Nucleus, nucleolus. Chromosome. Note=Cell-permeable protein. 22 hours after injection in the hippocampal area CA1, internalized by most cells at the injection site. Localizes at the chromosome periphery during mitosis (By similarity).
Sequence:
MAKSLRSKWKRKMRAEKRKKNAPRELNRLKSILRVDGDALMKDVEEIATVVVAKPRQEKMQCEEGRCDGADEEKDDMKMETEIKRNRKTLLDQHGQYPVWMNQRQRKRLKAKREKKRGKSRAKAAKGLAW
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MHLLRRAPHVVRAGRYISPLAAAKGPFLLPSSSAHAATRHFSLNWNSIAGMAAEDPEKTKEVRKYLQQSHDRIFENNKKWADEMRKKKPEFFSDLTAGQAPEYLWIGCSDSRIPAEAITGLEPGEMFIHRNIANLVNNIDLNVMSVVNYAVRHLKVKHIVVCGHYGCGGVKAAMTPKDMGLLNPWLRNIRDVYRLHQDELDAITDSEKKYDRLVELNVHEQCRNVIKTAAVQQCWAENEFPVVHGWVFGFGDGLLKDLKFDHEGQLAEIQKIYDLTKDF
The following text describes a protein:
Function:
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions. Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures. May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover. In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved. Spore formation and viability are severely impaired in deletion strains.
Miscellaneous:
MISCELLANEOUS: Two distinct classes of meiotic crossovers have been demonstrated in budding yeast. Class I crossovers exhibit crossover interference and require MSH4 and MSH5 for their resolution, while class II crossovers exhibit no crossover interference and require MUS81 and MMS4. While class I crossovers represent the majority of crossovers in S.cerevisiae, they are virtually absent in S.pombe which lacks orthologs of MSH4 and MSH5.
Subcellular Localization:
Nucleus.
Sequence:
MSQIVDFVEDKDSRNDASIQIIDGPSNVEIIALSESMDQDECKRAHVSSAEMIPSSPQRKSVSNDVENVDLNKSIELSAPFFQDISISKLDDFSTTVNSIIDSSLRNENNAKGNAKKLLDDLISDEWSADLESSGKKHNKSQYNLRDIAEKWGVQSLKNPEPIAVDCEYKTQGIGKTNSDISDSPKSQIGAADILFDFPLSPVKHENPTEEKHNSIANENSSPDNSLKPAGKQNHGEDGTSMAKRVYNKGEDEQEHLPKGKKRTIALSRTLINSTKLPDTVELNLSKFLDSSDSITTDVLSTPAKGSNIVRTGSQPIFSNANCFQEAKRSKTLTAEDPKCTKNTAREVSQLENYIAYGQYYTREDSKNKIRHLLKENKNAFKRVNQIYRDNIKARSQMIIEFSPSLLQLFKKGDSDLQQQLAPAVVQSSYNDSMPLLRFLRKCDSIYDFSNDFYYPCDPKIVEENVLILYYDAQEFFEQYTSQKKELYRKIRFFSKNGKHVILILSDINKLKRAIFQLENEKYKARVEQRLSGTEEALRPRSKKSSQVGKLGIKKFDLEQRLRFIDREWHVKIHTVNSHMEFINSLPNLVSLIGKQRMDPAIRYMKYAHLNVKSAQDSTETLKKTFHQIGRMPEMKANNVVSLYPSFQSLLEDIEKGRLQSDNEGKYLMTEAVEKRLYKLFTCTDPNDTIE
The following text describes a protein:
Function:
Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTTTAPAPQVYGGDEVATLVIDTGSSYTRVGYAGEDTPKLVVSTECGLMADEDVEMEDDTSNTTKKLNKYKVGDSANLPLPNMEVLHPLTDGIVADWDAVQNIWEYSLARLNADTKTHPLMLTEPCWNTQANKLKALEIAFESLEVPASYLVKDAVASAFAAGKGNALVLDVGSEVASVTPVIDGLVLYKPARRSQYAGDYLDRQIKKVLVSRGIDLTPRFEIKNKKAVEMGEPPVFTKRELPNVTHSFTDLQVSRILSEFKDSMCQVNDVPLTPEISGEAADRVFEFPTGYSTTFGADRLSTSESLFKPSEYPFDGETVPDTARGLSEMVVDTINASNVDVRAHLANNIVITGGGSLVQGLSDRVSKDVTQALSGLKVRVAAASNQEERRHGAWIGGSVLGSLGSFHQLWVSKQEWQEKGGDYLVEKKRFK
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERDFMGLAVKQEISDEPIDAAPLRSSQMQWSFSNKSPFQGAQDHKSYSGFMQKDIVSEKQSGVGYTMTTYPTHHRFVNRTAIPSRSPVVGTTDLRSSSKSSVAPAQLTIFYNGSVSVYDNISSEKAQAIMLLAGNGHPPLNSIPTVTAAAAPVQASMPRSSILDGFVVSQSQPFSTTPFRSSPTAITTSVSGSRFSGWPSTIIDMNANKQGGNILVPSNRVDQPQKVVNATGTVPQFRRKSLARFLEKRKERVVNTSPYADSTS
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MDSKQQRIGVIGTGAIGGFYGLMLAHAGHDVHFLLRSEFEAVNRAGLSLNSAVHGFRRLAPVQAYHSAQDMPPCDWLLVGAKTTGNDELAPLIRAAAAPGAKVLLLQNGLGVEERLRPLLPESLHLLGGLCFICVHRGEPGVIEHQAYGGVNLGYHSGPADERRRREIVEEGAALFRESGLESTAMPDLEQARWQKLVWNIPYNGLSVLLKSSTAPLMANADSRSLIEAIMEEVIGAAGACGFILPEGYADQLLAATERMPDYRPSMYHDFAHGRPLELAAIYAAPLARAAAAGYRMPRVEALHQALRFLEAQPR
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MVCVQTAKIAPPLHAPALQRGLPAQHKSLAAATALNMMRSHMASSDPSNSANKAHSDQPKKGLDSQLWHACAGGMVQLPPVGAKVIYFPQGHGEQAAAIPDFPRSGGTILCRVISVDFLADAETDEVYAKMKLQPEVAPAPLFGTRMGDDEELVSSPTVVEKPASFAKTLTQSDANNGGGFSVPRYCAETIFPRLDYSIDPPVQTVLAKDVHGEIWKFRHIYRGTPRRHLLTTGWSTFVNQKKLVAGDAIVFLRSASGELCVGVRRSMRGPGNGDSGISWHSSPGQRSLPQNSSRWEIKSESGYSELLSGNGSGTSGASFARNRARVTSKSVLEAASLAAAGQAFEVVYYPRASTAEFCVRASVVKASLEHSWYPGMRFKMAFETEDSSRISWFMGTISAVQPADPIRWPSSPWRILQVSWDEPDLLQGVNRVSPWQVELVSTLPMQLPPFSLPRKKIRPLDLQFGESQGGFMGLPMAALANNVLGQMNPWQSLSEEVPAGMQGARQERFYGLTLSEFQPKQRVAGLFLDGAYPLDHSMTSRGATTDLRLNNFATTTTTPHDYFQLQQANIINATNTGRSAYGTPAAATQSESTAPPSVAPKSGTKRTATFLLFGKSIDPNYNPEEQQLQQQQNSGVSGGCSSEGTSHQYKESTSQAQPSSNSSFEDGQADNNIINNNLGNKNASSGNVTNNTTDMTHKLFTNVTSTSLRLCQGESPDSGVTNESGSSKWMKEHSGADPDDDGVIHCKIFFEKEEVGRTLDLSLFGNYEELYDRLASMFTMDKSKLSGRVVYRDLEGSTIYIGGEPYGNFVKSVRRLTILAVPSSSTESRSAQSW
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Sequence:
MATIDEGPSASKESQTDILSDYKILETVEWIARHSFTIVGLQFPDELLSISVPIFRSLRSRLDSDEIELYIMADTTYGSCCVDHVAAQHVHAQAVVHYGQACLSITPSLPVFYVLPKFPISDEMVERTAKRMVESLYSMDPTFDVSNDSNQILLMYDVGYHWKSESITNCLKTNFNLPIVRHELGLEETKNLLIPPHSSASVAPSINQCSEQTCCQSSCQDSKPCSNQPIACTTTTTTTTPTTNIPISQEAGSSVLPSNSRGNKTDFSSYQVVFYVGSESSRLTHFLVTHPHLPVIAVDPNQTEEDSNDHSRLQQNNRTKKLLMRRYATIQRARDADVFGILVGTLGVRHYLEMINRTKKLIEEVFKKKAYIISVGKLKPEKLMNFAEIEAWVLVDCPESSLLTLDGKTGERFDPKQFGAPIITPWELEIALNSCIEPSNDDQSENQKRVWDGKLVLDFEQILSVWQAEDSFDTSAPKNGPPSPHSGDSDQQEGPVFSMVTGGYKYRRNWNDNHESESQSKEVQKLEMKDKQELIESVKGAASQYALSHRTYFGLEPRFGLDPPSKVSAGRYGIPQAYQDDHPDSAS
The following text describes a protein:
Function:
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKAHYIDFFKQAADKKIQWLKEELTKIRTGRPNPKIFDNLLIESYGQKMPLISLAQVTINPPREIIIKPFDPKSNTNAIYSEIQRANIGVQPVIDGEKIRVNFPQITQETRLENIKHVKKIIEQIYQELRVVRRDALQMIKKDNHNEDLENSLKAEIEKINKNYSNQLEEIQKDKEKELLTI