lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MADPIMHLQVVILSLILHLADSVADSVNVDGVAGLSITLPCRYNGAITSMCWNRGTCSVFSCPDGIVWTNGTHVTYRKETRYKLLGNLSRRDVSLTIANTAVSDSGIYCCRVKHSGWFNDMKITISLKIGPPRVTIPIVRTVRTSTTVPTTTTTTLPTTTTLPTTTTLPTTMTLPTTTTLPMTTTLPTTTTVPMTTTLPTTLPTTTTLPTTLPTTTTLPTTLPTTTTLPTTMTLPMTTTLPTTTTLPTTTTLPTTTTLPTTTTLPTTTLPTMTLPTTTTLPTTMTLPMTTTLPTTTTLPTTTTLPTTTMVSTFVPPTPLPMQDHEPVATSPSSAQPAETHPVTLLGATRTQPTSSPLYSYTTDGSDTVTESSDGLWNNNQTQLSPEHSPQMVNTTEGIYAGVCISVLVLLAVLGVVIAKKYFFKKEIQQLSVSFSNHQFKTLQNAVKKEVHAEDNIYIENNLYAMNQDPVVLFESLRP
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEKSITNSPVLSILSYCAASILMTVTNKYVLSGTSFNLNLALLAVQSIVCLTAISIGKSFGLCKFRSFNADEAKKWFPIALLLVVMIYTSSKALQFLSIPVYTIFKNLTIILIAYGEVLWFGGSVTSMALASFVLMVLSSVIAAWSDISGAIAVSGSATTTVTALNIGYFWMMSNCFASAAFVLYMRKRIKLTNFGDFDTTFYNNLLSIPVLLIASLLFEDWSPANLAVNFPPESRNLIFFSMVVSGLMSIGISYCSAWCVRVTSSTTYSMVGALNKLPLALSGIVFFGTPATFSSVSAIFVGFVAGIVYAVAQIQKKKAEAALPK
The following text describes a protein:
Function:
Facilitates the transport of serine from the cytosol to the mitochondria by interacting with and stabilizing Sideroflexin-1 (SFXN1), a mitochondrial serine transporter, playing a fundamental role in the one-carbon cycle responsible for the synthesis of nucleotides needed for mitochondrial DNA replication. Plays an important role in the phosphatidylglycerol (PG) remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. Specifically involved in the exchange of the sn-1 acyl chain from PG 16:0/18:1(9Z) (also known as 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)) to PG 18:0/18:1(9Z) (also known as 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)), a step needed in the bis(monoacylglycerol)phosphate biosynthetic pathway. May have acyltransferase activity although the mechanism for PG remodeling has not been determined.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum. Mitochondrion. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface.
Sequence:
MSLAAYCVICCRRIGTSTSPPKSGTHWRDIRNIIKFTGSLILGGSLFLTYEVLALKKAVTLDTQVVEREKMKSYIYVHTVSLDKGENHGIAWQARKELHKAVRKVLATSAKILRNPFADPFSTVDIEDHECAVWLLLRKSKSDDKTTRLEAVREMSETHHWHDYQYRIIAQACDPKTLIGLARSEESDLRFFLLPPPLPSLKEDSSTEEELRQLLASLPQTELDECIQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEAIVKHSEISTHCDKIEANGGLQLLQRLYRLHKDCPKVQRNIMRVIGNMALNEHLHSSIVRSGWVSIMAEAMKSPHIMESSHAARILANLDRETVQEKYQDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDSEQAVIEKPMEDEDRYTTCWPKTWLAKDCPALRIISVEYDTSLSDWRARCPMERKSIAFRSNELLRKLRAAGVGDRPVVWISHSMGGLLVKKMLLEASTKPEMSTVINNTRGIIFYSVPHHGSRLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLNFVETLPTYIGSMIKLHVVPVESADLGIGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIREALAKDLEN
The following text describes a protein:
Function:
Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
Sequence:
MKKKVLALAAAITLVAPLQNVAFAHENDGGSKIKIVHRWSAEDKHKEGVNSHLWIVNRAIDIMSRNKTLVKQDRVALLNEWRTELENGIYAADYENPYYDNSTFASHFYDPDNGKTYIPYAKQAKETGAKYFKLAGESYKNKDMKQAFFYLGLSLHYLGDVNQPMHAANFTNLSYPQGFHSKYENFVDTIKDNYKVTDGNGYWNWKGTNPEDWIHGAAVVAKQDYAGIVNDNTKDWFVRAAVSQEYADKWRAEVTPMTGKRLMDAQRVTAGYIQLWFDTYGDR
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.
Sequence:
MAPTCNETLSLSLSISHQVLCIYISHLLVTAFLPHYLSRLFEHCKTTKSIIRIILVPSPLFYIFFYKMVSQNVVVPDATTGIITVSTVSNSSVFTPSAQKPPTAPGHISISKKKLLKSLEISGDQSQRLNSWVDSMRASSPTHLKSLPSLSSQEELNSWMKRHPSALDMFERITEASRGKEIVMFLDYDGTLSPIVADPDRAFISSKMRRTVKKLAKCFPTSIVTGRCIDKVYSFVKLAELYYAGSHGMDIKGPTKGFSRYNKDKPSVLYQPAGDFLPMIDEAFKQLVEKTKSTPGAKVENNKFCLSVHFRCVDEKKWSELALKVRSVVKNYPTLKLSQGRKVFEIRPMVKWDKGKALEFLLESLGFDNSSDVFPIYIGDDRTDEDAFKLLQERGQGLGLLVTKFPKDTNASYSLQDPLEASDGFPATVGGVETSSAMNTKGPMEFFSINNHCP
The following text describes a protein:
Function:
May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MAKAVVLLLVVTPFLSLLPFSSLALNQDFCVADLPRGDTPAGYPCKPQTAVTADDFYYRGLGTTGPTINPFNIGLSSAFVTRFPGVNGLGISAARVDFAPGGVVPLHSHPGGTELLYVIEGAMAAGFITSLTNQVYTKTLYKGDLMVFPQGLLHFQYNLGNDTAVALSSYSSANPGLMILDFALFANNLPSDIVSKLTVLDELEVKKLKALFGGSG
The following text describes a protein:
Function:
Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates (By similarity). Involved in the regulation of pollen and anther development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVFGRITELFTAASSRLPAGSQSSVPYMPTGSSPDVGTSVSDSISIGNGGRKNCLRHSASLQDFSSYHGFDPEESILPREAISWGQNGSSFSKEKGSVPNGTNPSTRRKLIRAVMIVMCLFLFAFLVYIVSMYIYTNWSRGASRYYVVFDCGSTGTRAYVYQASINYKKDSSLPIVMKSLTEGISRKSRGRAYDRMETEPGFDKLVNNRTGLKTAIKPLIQWAEKQIPKNAHRTTSLFVYATAGVRRLRPADSSWILGNVWSILAKSPFTCRREWVKIISGTEEAYFGWTALNYQTSMLGALPKKATFGALDLGGSSLQVTFENEERTHNETNLNLRIGSVNHHLSAYSLAGYGLNDAFDRSVVHLLKKLPNVNKSDLIEGKLEMKHPCLNSGYNGQYICSQCASSVQGGKKGKSGVSIKLVGAPNWGECSALAKNAVNSSEWSNAKHGVDCDLQPCALPDGYPRPHGQFYAVSGFFVVYRFFNLSAEASLDDVLEKGREFCDKAWQVARTSVSPQPFIEQYCFRAPYIVSLLREGLYITDKQIIIGSGSITWTLGVALLESGKALSSTLGLKSYETLSMKINPIALISILILSLLLLLCALSRVSNCLPRFFRKSYLPLFRHNSTSASSVLNIPSPFRFQRWSPMSTGVKTPLSPTVRGSPRRPFSFGSSIQLMESSLYSSSSCVMHSCSSDSLGDIQYDSTGSFWSSPRRSQMRLQSRRSQSREDLSSSLADSHMLKM
The following text describes a protein:
Function:
Acts as a target recruitment subunit in the E3 ubiquitin ligase complex zer-1-cul-2-elc-1.
Sequence:
MSHTADIPLEAPTLLKLASSSVQSQINNDEYMETVILPVPLSQELFARFRNKWNIHNHGPAPVEHLGPPTDEPRPDQGNIDMIKQVFRIWSDSTRLPLEKLNLTGATVDDQIFVDLLHAHAHSITELDLTNVTGVTDLSNAYLYARSTHFPMLTSIRMTSMDLVTGHQPRRKNGIASTEFRALFMLGEEALAEARGQMERDGLRSPLSPSSQPSSIQSDHQSLDALVPCDSPVEPPLITARAPNVKRLFLPRCPAKRTTIDEEEQNTHVILTKILSPLQQLEVLDLSYWSKTDDMRCLQPLSNTLTCLILYDVPDLYHAVPNICHMTELRILDVSQSNRDSGLYPHPVTTLNKLIVSLKYLTHLDISSTNLATQPSSHDNPARYRESVRTDICGLQSLVRPLKYLGLFNCESASHVREIPAEVVSGDANEDQVITSLQMYKDRAGLLQNVLNESYQLYRFGNSNPLTRHTEALHLVLEAMHRHLADSTLQIAGSASLFYIIRKVDMNRDTKRRVVSALLSGMEVHMEEQVMVRNCCLSLCQFEIPQDILFDYSRLAVLLVSVLQHHNADNLTQRIVVFLLNSMACHVEGDQKVQVGSYGAIEMILDQIARKHTANVCDDVMEVGWSFLWNITDETPVNCELFLNANGLDLFQKCYEAFKTERELVRNMMGLIGNIAEVDELRSQLMKDDYVKIFCALLESQEESIEISYNSAGVLAHMVSDGEEVWKQMTVCRNEVMQRIVEATSSWKLATRRFINYRSFRPILRLLPLYHAYASQHWAVWALANLTTTDGEKYCAYVRDEGGVPLLEELVSNAITTTDIRTLANTVLENIRNVENKRNPKSIPADLAHSSNSPTFVPSYVSDVEEEDEGDVEADEEVQDFVNVDFDDYALPMEY
The following text describes a protein:
Function:
Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MDAWVRFSAQSQARERLCRAAQYACSLLGHALQKHGASPELQKQIRQLEGHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGVSGGIEPGGPGGPGIPGGGLPQVALKLRLRVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLICPWLRLKP
The following text describes a protein:
Function:
Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Translocates from the cytosol to the nucleus when phosphorylated.
Sequence:
MENERAKQVYLAKLNEQAERYDEMVEAMKKVAALDVELTIEERNLLSVGYKNVIGARRASWRILSSIEQKEESKGNEQNAKRIKDYRTKVEEELSKICYDILAVIDKHLVPFATSGESTVFYYKMKGDYFRYLAEFKSGADREEAADLSLKAYEAATSSASTELSTTHPIRLGLALNFSVFYYEILNSPERACHLAKRAFDEAIAELDSLNEDSYKDSTLIMQLLRDNLTLWTSDLEEGGEQSKGHNQQDEN
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MESTPARGGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPFLAKNWVMRMLFLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRIALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGTAHQPGFIIVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
The following text describes a protein:
Function:
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Sequence:
MTKKEIAEEIYDRLIRDYNVKIQKKEVYNLVSEVFTIIQECLLKGEKVKISGFGTFVVKTRKPKKGMNIKKREIVEVPERKIVLFKPSKNFIKS
The following text describes a protein:
Function:
Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.
Subcellular Localization:
Nucleus.
Sequence:
MADPDYEDVNYHRKRMRLEDSGAKELAIQKIEDIITNQFDTELRYKEREIATIDQRIYQVRAMLDKIRACIIAKFYGTPKPLEQLTDRTATDPDTAENEDIISRNLSSQKLTFINPNHPAESIVKEARLQNSTATKTTQESKAIQERSSRNEGDISSRFYTKKRIIIGNTSKYIPLDQRDEHNQSTHKWMVYVRGTEEVEPEIHQFVKCVWFFLHPSYRPNDLVKVNQPPFHLTRRGWGEFPVRVQLHFVDSHNKRVDVIHHLKLDRTYTGLQTLGSETIVDVELYHEWKTDVDTVSNAPVSPDNLDEIVDELISKDSNPEIVGDNDMFEQVTSPDTFKYEPEIETKFDLEQLLEEGAKVYQLISENSTPLSQPYCAKNCETFFSWNIGKRRAAEWQRAIDMKKFIGSHSPGLVQLPTTKQITIWCRQHGYTPVDLNSKRDGGIANFCHICGRLLYTGNQQEFKENMKTNHVCKTSFDLLAYDNEAITEINVVDNSEAHESIDNKRTVIESENQEVSIPPLPPELQWIRDTSKEIIGVDFQTVKKGDVETPLSERIIFEACKGFIKHILRKSVAVAAKGSSSSVIDYVLVPSHIHAAIKEIENCDFITKSCLGQEIAAINELES
The following text describes a protein:
Function:
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Membrane; Peripheral membrane protein. Postsynaptic density. Synapse, synaptosome.
Sequence:
MDTSKDSELWCEETTSLLQFDHAEDNTFDSNPIRPTNAVVVDEEKANGDDQDTALIVIGSPRNGPRPFQTERRKESKKLASEQDDAKPEKESAASKRMDDIAFVSNDDLPDPVLYADGCVDDNKIIMLCQRQEMERLGMTVSSGTVVIKKDTSNLIGISIGGGAPLCPCLYIVQVFDGTPAAREGTLQSGDELLGVNGVSVKGKTKVEVAKMIQSATEEVMIHYNKLHADPTQGETLDIVLKKMKHRLVERMSSSTADTLGLSRAILCNDSLVKRLQELERTETMYKGLVDHARRMLKAHFDVLQTYQAFGNIFASISVREPQPRASEAFRIFGELHRNMEKDGIKMIKTLKPILADMGTYLHKAIPDTKLTVKRYADAKFSYLSYCLKIKEMDDEEHGYAAIQEPLYRVETGNYEYRLILRCRQEARLKFAKLRSDVLEKIELLECKHARDLASQLRKFIEGLATLASETVERLESIPNLFPIEVDLKASAFQYKSAIKFQAEEYTDEEIPQAEEAIEQVETAKSAQAKTTGDLEQSNGTDVSGQLLGGFEEIDLNKGTSAGPSEHDLLNELGLAGIDLSVGSKPISHNLMDDLLVPELFK
The following text describes a protein:
Function:
Involved in the biosynthesis of prenylated phenolics natural products which contribute to the bitter taste of beer and display broad biological activities (Probable). Catalyzes the biosynthesis of xanthohumol. Methylates desmethylxanthohumol and xanthogalenol, but not caffeic acid, prenylflavanones, simple phenols or phenylpropanoids.
Subcellular Localization:
Cytoplasm.
Sequence:
MESLRGQEQIWQLMFSFVDSMALKCAIELRIADIIHSHGKPITLSQIASGIRSNSNSSISPNIPYLSRIMRFLVRKNIFTEHQEDNDEVISLYGLSDSSRWLLRDFKSSLAPMVLMQTHPLSMAVWHFLEDYVRNSSNTFEKAHGCNIWEFSSANPDFNKIFNNAMASIVPIYMGAVLSSYKDGLGCIKGTVVDVGGGTGGSISELMKYYPNIKGINFDLPHVIATAPALDGVTHISGDIFESIPSADAVLMKGVLHCFSDEKCVKVLRNCRKAITDKKNGKIIILEIVLDPTSNQIFDETRMVYDLLIPLFSGGKERTELEWKRLLNEAGFTSIKITKIPIIPAIIEAFLV
The following text describes a protein:
Function:
Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
Subcellular Localization:
Mitochondrion outer membrane.
Sequence:
MELHIWPSDFGLPTIDVVSLQFLACSKMCASPVRVIQSTRPWRSPSGELPMVAQTEGEAKPVTDFEKFVDILKKCGQDVVIDADLTTIEKAQLDAFSCYLHHNLYPAVMHTFWTDELNYNTVTQYWYASHLHFPYNLYYLEKRRKKALRLLAGKNDTEILKEAFMALNTLSTKLGDNKFFCGNKPTSLDALVFGYLAPLLRVPLPNDRLQVQLSACPNLVRFVETVSSIYLPLGEDELKRQQANRKMWQSRISKAKADKEAAKTTEEASESLPEEPPMRDAILFTLGALTLSLVFAIHTGLIQVSVEEEISE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity to ensure proper cell division.
Subcellular Localization:
Chromosome, centromere.
Sequence:
MRGGAAGKRRTTVGFGGAPPPPPPSIEQQRHLFNSRDSDASFASSRPSSIGLGGRGASDDRSSMIRFINAFLSTHNFPISIRGNPVPSVKDISETLKFLLSALDYPCDSIKWDEDLVFFLKSQKCPFKITKSSLKAPNTPHNWPTVLAVVHWLAELARFHQHLVSNSTSVPEDNSMNFFAIQSFGHFIRGEDDKVNDLDSQFLGKLEAEKTSVAETISGCEKISGELEAKLESLRKGPSKKESLEKVKADLENDVNKFRTIVVEYTDRNPAMEKVVEEKAKELKAKEEERERISVENKELKKSVELQNFSAADVNRMRRELQAVERDVADAEVARDGWDQKAWELNSQIRNQFHQIQTLAIDCNQALRRLKLDIQFAVNERGETPAAVMGVDYKSVVKPALCSLCDGIKGSSAEKVEELVTLQHHKSEMASKIESKRSLLGSIQLQINDLEEKMKLVKKETQELSTKCDLEAKTLVESVKAEALNLEVVEKEAAEFVKASELRLQEAVKESEEEVQACAAQLFALIDSISKQKEYMDSKISEIKTGVADTASAVSEIYKANFKKNLGI
The following text describes a protein:
Function:
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
AAVRGLRVSVKAEAPAGPALGLPSPEAESGVDRGEPEPMEVEEGELEIVPVRRSLKELIPDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRSEVNLAQRNVALDRDMMKKAIPKVRLETIYICGVDEMSTQDVFSYFKEYPPAHIEWLDDTSCNVVWLDEMTATRALINMSSLPAQDKIRSRDASEDKSAEKRKKDKQEDSSDDDEAEEGEVEDENSSDVELDTLSQVEEESLLRNDLRPANKLAKGNRLFMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWKRRYHSRRIQRDVIKKRALIGDDVGLTSYKHRHSGLVNVPEEPIEEEEEEEEEEEEEEEEDQDMDADDRVVVEYHEELPALKQPRERSASRRSSASSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKNIRNSMRADSVSSSNIKNRIGNKLPPEKFADVRHLLDEKRQHSRPRPPVSSTKSDIRQRLGKRPHSPEKAFSSNPVVRREPSSDVHSRLGVPRQDSKGLYADTREKKSGNLWTRLGSAPKTKEKNTKKVDHRAPGAEEDDSELQRAWGALIKEKEQSRQKKSRLDNLPSLQIEVSRESSSGSEAES
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Sequence:
MAIKKRSATVVPGASGAAAAVKNPQASKTSFWGELPQHVMSGISRMVPTLIMGGVILAFSQLIAYSWLKIPAEIGIMDALNSGKFSGFDLSLLKFAWLSQSFGGVLFGFAIPMFAAFVANSIGGKLAFPAGFIGGLMSTQPTQLLNFDPSTMQWATSSPVPSTFIGALIISIVAGYLVKWMNQKIQLPDFLLAFKTTFLLPILSAIFVMLAMYYVITPFGGWINGGIRTVLTAAGEKGALMYAMGIAAATAIDLGGPINKAAGFVAFSFTTDHVLPVTARSIAIVIPPIGLGLATIIDRRLTGKRLFNAQLYPQGKTAMFLAFMGISEGAIPFALESPITAIPSYMVGAIVGSTAAVWLGAVQWFPESAIWAWPLVTNLGVYMAGIALGAVITALMVVFLRLMMFRKGKLLIDSL
The following text describes a protein:
Function:
Regulates arginine biosynthesis genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRDIKELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVKAQLIETFADKIFSCLTDDGSILVIARSGSLAEEIFEQVKNW
The following text describes a protein:
Function:
Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.
Sequence:
MELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQHQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSRSMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAGDILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALNARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAGKSVAIFGDTAPCEAALALAQGVDVMVHETTLDASMEEKANARGHSSTRQTATLAREAAVGRLIMTHISSRYDDKGCQRLLAECRAIFPATELAYDFSVFPV
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MSGLVGRRIAITRPAGRGDTLAARLQALGAIPLLTPLIAYMPPPDPAPLQQALNRLATGAYHWLVVTSRQTVQVLADTTIPESTAIAAVGKATASDCRRAWGREPTVVPDTEIGSALPAIMGQLAGKRVLLPCADIAPPTLTEALRAAGADVDRVTAYCTVAGPGLADLQRMIDDGAIDAIVLASGSAVRQLQQLHVPTGLPPLVCIGPSTAAVCADLGLPIAGIAERPNDDALIAVLEQVFTPYCEVKE
The following text describes a protein:
Function:
Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. This subunit may stabilize YoaA and/or stimulate the helicase activity of YoaA (By similarity).
Sequence:
MAKTAQFYILTENCTLTVEEIACNLAASIWRSGKKVLISCESEAQALEIDERLWQRDPNEFVPHNLSGEATQYPTPIEISWLGKRNLQRRDLLINLQQEIPDFSHSFTQIIDFVPKDDALKTQARERYKQLRLQGWNLSTENVG
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (By similarity). Autophagy is essential to fungal development, production of appressorium turgor, and pathogenicity in rice blast disease.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MADRSARRARPGDDSVGQFVIGAEIGKGSFAQVYMGKHKVSGAAVAIKSVELARLNKKLKENLYGEINILKTLRHPHIVALHDCVESATHINLMMEYCELGDLSLFIKKREKLSTNPATHDMARKYPNVPNSGLNEVVIRHFLKQLSSALKFLRESNLVHRDVKPQNLLLLPSPEFREVNKLARPILTASQDSLVPVAGLASLPMLKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYERYDAKADLWSVGTVLFEMIVGRPPFRASNHVELLRKIEAAEDVIKFPRETTISSEMKGLTRALLKRNPVERISFENFFAHPVIISSIPGLVEDDIPKPEASEQRSSSKDTRAASKSDDPIASPRKYSFRRHPTDNDQIRDQFRRVEPPSSAAESAPSRQTSAFSGIAAEARKQAAAEASARTGQSSRNEPGDNLVPRRPQAQPSTSAPSKPGLYEERRRGISNASLNRSNRESSSPTSAALANDSARAPPQQTSRRVQAEEREKAAQDVAFERDYVVVEKKHVEVNAFADEMAANPRLGGQGTPLSPKSGQIVRRATQQGNPTSTTGAIPAAPSRTMQIAQGTQRHYHERGTSLSASPGSTASFITKAIQDASLRLLGIKYPAGLTKGASPPELYNPYPAYPTPSPPVGLISSGKQSTPVDEDARVAQLIEEHATRSDVVYGFAEVKYKQLVPLAPSAEHGLGGTTLEDMPTGEEDVLTVEAIVSLSEEALVLYVKALTLLAKSMDIASLWWARKNRGDQANNALSSTRDSVNTQTLSLRINSAVQWVRSRFNEVLEKAEVVRLRLMDAQKRLPDDHPSHPSNHPQGSESVNGASAEGVFLTVGVTAEKLMYDRALEMSRTAAINEITNEDLAGCEISYVTAIRMLEAVLDNDEDAPKRRLSANMDDSGGDGEDGHAEINADDQQAVQKMIHMIRSRLTSVRSKVRMISNASKAQQQSQPQSLIRRRSGDVTPRSVPSYSS
The following text describes a protein:
Function:
Cell surface receptor that plays a role in the regulation of IL-13-mediated responses. Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation. Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The cytoplasmic domain functions as an inhibitor of IL-4 or IL-13-dependent activation of the Jak-Stat pathway.
Sequence:
MAFIHLDVGFLYTLLVCTAFGSMLSNAEIKVNPPQDFEIVDPGYLGYLSLQWQPPLFPDNFKECTIEYELKYRNIDSENWKTIITKNLHYKDGFDLNKGIEAKINTLLPAQCTNGSEVRSSWAETTYWTSPQGNRETKIQDMDCVYYNWQYLVCSWKPGMGVHFDTNYQLFYWYEGLDHSAECTDYIKVNGKNMGCRFPYLESSDYKDFYICVNGSSESQPIRPSYFIFQLQNIVKPMPPDYLSLTVKNSEEINLKWNMPKGPIPAKCFIYEIEFTEDGTTWVTTTVENEIQITRTSNESQKLCFLVRSKVNIYCSDDGIWSEWSDEQCWKGDIWKETLVFFLIPFAFVSIFVLVITCLLLYKQRALLKTIFHTKKEVFSHQDTFC
The following text describes a protein:
Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
Subcellular Localization:
Nucleus.
Sequence:
MESLSAMAAAVDPSWEDEDEEEEEEEIEEVEQFVLVELSGIIDTDFLSKCENKCKILGIDTERPILQVDSYVFAGEYEDTLGTCVIFEEGVERVDPEGNDKTVLKYKCHTMKKLSMTRTLLTEKKEGEENIDGVEWLQMKDNDFSYRPNMICSFVHENEDEAAGPASDKPVEAEDQESEMKGDAEQTHEQEQAQEVGDPGPTGDTPSDIESSVFMGTQDGNVSQNSQS