lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the glucosylation at the O-5 position of anthocyanidin 3-glucosides to form anthocyanidin 3,5-di-O-glucosides using UDP-glucose as sugar donor. Anthocyanidin 3,5-di-O-glucosides are molecules that are responsible for pigmentation. Also acts on anthocyanidin 3-O-(6-O-malonylglucoside). Much less active with hydroxycinnamoylglucose derivatives. No activity in the absence of the 3-O-glucoside group.
Sequence:
MEQQRHVLLVTFPVQGHINPSLQFAKRLTAMGIKVTFATSLYARRRMSRTAAGLPKGVTFAAFSDGYDDGFNPGNDDAGKYMTEIRSRGSQSLRDTILAAAEQGCPVTQLVYTLLLPWAPEVAREFHVPSALLWIQPATVLNIYYYYFNGYRDEIAANSNDATWQIQFPGIPALNFSKRDLPSFILPSSSDKHSVELPSFKEQLETLDAEKTKPKVLVNTFEALEPHALKSIDNYELIGVGPLIPSAPSDKSFRGDLFEKSDDNSVELWLNAKPESSVVYVSFGSILKLPKAQMEEIAKGLLESDRPFLWVIRINEDNKNEEEEEKLSCLDELEKIGKFVPWCSQLEVLTHASVGCFVSHCGWNSTLESLSSGVPVVAFPQWTDQGTNAKLIEDVWKSGVRVRGVGGDGVVESGEIKRCIEEVMDGGKRSRELRANAREWKSLARGAMDENRSSCKNLKAFLEEN
The following text describes a protein:
Function:
As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSNIYIQEPPTNGKVLLKTTAGEIDIELWSKEAPKACRNFIQLCMEAYYDNTVFHRVVPGFIVQGGDPTGTGTGGESIYGAPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVEIDEEERPLNPHKIRSCEIWKEEGFADVCSGTGCDPYAEGRMSVSRPHRAERFRLKVLFNPFDDIIPRDGKKLKKDKPEDETKKLKSKGTKNFSLLSFGEEAEEEEVEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESEQGADVMRDSDDDENESEGEDADDMAGDEKDHVKERIAKKLKGMRENVKALAKESEKEAEKKSASRSEELRREVRQLKRELLVARQKKEEGATRPTGKEEAEEEEAPESAVAEYRREKKKYETLRKQQPKKGSSREEQTLAMLNQFRSKLTQAIADTPECEVSDAEVDDDEGWMSHVLQFEDKSRKVKDASLQDEDTFEIYDPRNPVNKRRREESKKIMREKKSRR
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MSDRTIVENFRDREGYRCGYCGSTDSNYSHGMWAHQLTCQDYQDLIDRGFRRSGKYCYKPDLNKMCCPCYPIRCEALHFRATKSQKKVLKRMTKYLTVPQAEGGRTIPCLLQQGNYHVPLQKTRPCIVKMLRMTGKVLTFITVCNYDECKCQITLDYGEMCGLREKSQITRFSTITPGKGPDPSKPPCRKAKDIRRQRRQQKKKNGVEEYRRFLCSSPLVVSAPHMGYGSFHQQYWLDGRIIAVGVLDILPSCISSVYLFYDPAYSHLSLGVYSALRETITLHTLCAQRRIAGFPLSSVGLNSTPTNTRDWIRLGRVIYPNFPSTDINKMLILYERQAMPYLIYRAIKQNEDDEGDDNDDTDEIQELADMVGPAVAQRMLLFRS
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDIYGLPSNNTTTQDLFRIDDLLDFSNDELFTSSSSAATANTTAIASDTDHLPQAQHQSFDSFNPSSDFTGDLCVPSDDVAELEWLSQFVDDSCMDFPANSLAGTIVRSDTSLSGRGRSKRSKATNSAANTTTWNWTSSESESGNSKQKRENHRQSSPIPEGGVRRCTHCASEKTPQWRTGPLGPKTLCNACGVRYKSGRLVPEYRPASSPTFVLTQHSNSHRKVLELRRQKELLRQQQLQQQQQQEEGQGQIYRHQRDFEVC
The following text describes a protein:
Function:
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRIVWKPLKIRLPVWRRYQSNISINSIRNVGIIAHIDAGKTTLTEKMLYYGGFTSHFGNVDTGDTVMDYLPAERQRGITINSAAISFTWRNQRINLIDTPGHADFTFEVERSVAVLDGAVAIIDGSAGVEAQTKVVWKQATKRGIPKVIFVNKMDRVGSSLGSTIRSIYTNLDCPYPLVLQLPVYSDGLQERKFLGILDILQQKMILWDTSDNKLGTDGTHVQELPIPESHMERFIEARNALVMSLCDVDETLCDEYLENEDSLAFTNDRLFKIIKQKTISGNVVPVLCGSSLKNIAVQPIMDAIIDYLPSPVEFYEKNASKETSSDKIISLDKRPLLAKIFKVIHHASRGILTYVRVNEGTLSRGMMMFNPRTKKSERAIRLYNVFADQTQEVDCISAGNIGVISGIKQFHTGDIIINKENSKNFHEYLSGNQSVISIPEPVCIASIEPYSLKDEPALLEALANMNREDPSFRYTQDLENGQLLIQGMGIMHLQVSYERLVSEFGARASLGKVQVGYRETLIDVSFNSVTLSTENKENLIINVYLIPISDEGDETLKKYFSEGEIQKVRSKGQEDGVLFYGWKPENSCTLPDHLSFQRIQENIYFGIVAGLSHGPLHGFPLTNLQSFCTISSFLSNDFPLSLLTQASMKATKNAVFSLYKRSPKSFRILEPYMDVTITTPEEYVGIVSKDLVGKRGATIKEITEIGKNAASKDSQIAIGILGERYLPADEPSSVKANNASSLLQSSSVIKCIRAQVPLEQILDYNSVISSLTKGNAKFLMSHPMESQTPKLVNYGSSFHPMSMQRQKRIFP
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
PSFGGVLLIPFPPSSFSSLVFACDHLIKQSQSALSNSVKKREMKSKRDYRGKDESLLDPVPSSLPPPLSIPFSILSLLTHVKWQLTIPPRGLAGTPQYVSGFQYVATNTQPTIQRVFDVNNGNVGNVNGFNNGFNNGVNNGFSSVQRDTSQKGNFVRSMLVDQRINSLDPSFYDCVYSVANSASTVIEQCYKDIGCCASTCCPNDAWRDKYGWAVALIVIFCILMLIALFVTLFCWLFNRSADKNQKKELLTNAGLSPAPSQPISLRNNLDDFQKMMKGFFKMTDNIPLTPNRRSNFGSAPLRYKYVDKTEYAANKGILDQVFESDLVLTTSQMSDVIADFQERVTGKKIRRRAKRKAIIGDRFRWPNATVPYSFKHADGKWVSVIRKGMAKWERETCIRFVPHTNQRDSVEYFRGGGCYSSVGRIGGKQWISIGYGCEGGGIVAHEIGHALGFWHEQSRPDRDTYININEDHIVKGTKGNFEKRMDIEDKDIPYDFGSVMHYGPQAFTNDWKYVTIETKDHRFQHTIGQRADISFVDVKHANRLYCGHICKFPLNCENGGYEDPLDCSKCKCPPGLGGIRCDRIATSTAGCGGEILVTGLWQTLTNSKIGECYWKLYVSEHKEGRMMYGLLPSIPLQTPTGKIHFEVLESNYKCDSSCADNYLEIKHTSKLEQTGFRQCCNAVPGPIISEGNQVIISSVAVERPANFTIRYILDSSAGLPKPPPAAWEGAGGLTSLLGSEAGIDNTFEKYVLTQLPNVLHTTSAQVPNIMNLIQAFLGR
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MYNLFFVKITFFALTLTFLNCNAAKEKTNSGSDKLQQVLKFTSQTGYFNVDGHKFKSYVKTSLKPYGVFLLLSVSMPERKCSHCGDALESFKLISSSWRFSEDFENDVFFGFADFDAGGMDVFQSLQIRSAPVMLYFPPYELKYQSMMIEKYGLSAEGFANFLQRVTSRKIIIKHPPNYTVLMSVCASIAVLVFLFYMDVINIKLINTALQMWSGATIVMFILLMISGFMWNHMRRPPLVHEQENSIIYIEHWGDGQLLAESFIIFFLNLLIGIGIVLLAQPRTLPITARKWCAYVGISVVCIFFYFLLGVFKKKYEGYPYGQLS
The following text describes a protein:
Function:
Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNLFVALSKKKKYQHKLFAPYLRPSTDTTTTETRFMLSTCLIRNCVFIRPRLSVICFKAIRYQSKKSDFPDYTKINDPKLREIIEGSNFGTEAILKKQREDQDKKKKMEQERKRLEQEREVDRRREEKRAKEESESNKTDNDNEANQHTDDKLAKVNEKLESNFSKTESGKLRGEDTGTRETVVETEEEEELKLKAENKIIATSKDSVDESDIPNLAKEINETIQKEIAGLPSQKAKNQSKLAKNLTKYLDSAHDTILTATRALNDVTGYSAIEKLKKSIETQEDDLKKAKEKVKQCKIAYGEAIQRRSHSQREVNELLTRKHNWSSNDLERFTELYRNDHENEIHEQEAEKKLDEAESKVDGVQLKLTQSILTRYHEEQIWSDKIRRSSTWGTWVLMGLNVLLFVVATFIVEPWKRSKLVSAFEDKVKQVLVGISQENEQILDPIIEKLEPTDGQVPIKTSFDFKFVTNTWHGLKAALVRNYEALMSPEITNLEFDKFEFELFTMTVAIVAFSMGSLIVSLFK
The following text describes a protein:
Function:
Activates transcription of the blt gene in response to structurally dissimilar drugs.
Sequence:
MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGYRYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELKQLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHEVQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYEIGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV
The following text describes a protein:
Function:
Cleaves the sulfated polysaccharide porphyran at the (1->4) linkages between beta-D-galactopyranose and alpha-L-galactopyranose-6-sulfate, forming mostly the disaccharide alpha-L-galactopyranose-6-sulfate-(1->3)-beta-D-galactose. Some longer oligosaccharides of even number of residues are also observed. Inactive on the non-sulfated agarose portion of the porphyran backbone. Displays a strict requirement for C6-sulfate in the -2 and +1-binding subsites.
Subcellular Localization:
Periplasm.
Sequence:
MKKVLLFLIFLVSANLSAQLPSPTNGKKWEKVEQLSDEFNGNSIDTNKWYDYHPFWEGRAPSNFKKGNAFVSDGFLNLRSTLRKEPSSVQDPFKDIWVDAAAAVSKTKAQPGYYYEARFKASSLSMTSSFWFRVGQFSEIDVIEHIGNPSKENRQDDLPYQYHVNTHYYGKHAGLQPLGTEYKMPGRGRDNFYTYGFWWKSPNELLFYFNGKQVMRIVPRVPLDEELRMIFDTEVFPFATAGVANIGLPKPENLRDNSKNTMKVDWVRVYKLVDGTAAEDSSDAPIGSYISLKKTQGDGKFVTGEKDGSQLVARGSTVQSWEKFKVEKHPKGGITLKANSNGKYVQVQGSDINKPVRAAGDFQGDWEQFEWKSKGNGLVALKNVLTGKWLQAPWTENNAIIRPKGPVDNGWETFAWKKETSPTASTALSAQLETKTVDGIRVYPSPASETLTIEGVEGENGLRVFDSTGNPVLKKEGILGRKERLNVSGLIKGNYLLRTGSGEQTWFQKN
The following text describes a protein:
Function:
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTVTAPEKAPAADVPKAGATRLVDRIFKMRELAILLVFLVMIGITQAGNSEFLSEQGIKDLLLNATILVLVATGQSLVVITRNVDLSVGSTLGISAFAAGTYLQGGGNPVVAVLLAVLTGVGFGLLNGALVSLGQVPALVVTLGTLYIIRGIDSIWVGSRQITAADLPGGFVDFGSGGISAVPWLAMIALAVLVATAYYLKHFGSGRELYALGSNPEAARLAGIPVRKRILAAYTFCGALAGLAGALYLARFGNVDSGTGNGYELTVVSAVVVGGVVFTGGSGSVYGAALGALLLTSINSVLPALGVSSVWVLAINGILLILAIAVDRIVALRVANALKKRNARHG
The following text describes a protein:
Function:
Transcription factor which is a downstream target of gcm and repo. Directly or indirectly activates the transcription of locos and pros, which are essential for the development of some glial cells. Plays an essential role in defining the cell shape and migration characteristics of longitudinal glia that enable them to establish a normal axon scaffold.
Subcellular Localization:
Nucleus.
Sequence:
MQLRVHPTMDCSGRSTSNIERDSDLGDDLSHGDRTDDEMRDCDSVDGEHHQLSAKAAIAARLSHTVSGGGGSFASPEPQTELPLSHHHQLPPNHPLNALGSFMGIGGLHSIPNLQHSDVLEKLKMQVRDMKVGLMEQDYAAAAHAAAFGANMLPTTISSGFPLPHNSVAFGHVTSSPSGGNGSSYNGGTTPTNSSNSNATTNGGGTAGPGGTGGSGGGGGGGGGGGGGVGGHQFSFASPTAAPSGKEARHFAANSASNSSTSSEASNSSQQNNGWSFEEQFKQVRQLYEINDDPKRKEFLDDLFSFMQKRGTPINRLPIMAKSVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQYMKYLYPYECEKKNLSTPAELQAAIDGNRREGRRSSYGQYEAMHNQMPMTPISRPSLPGGMQQMSPLALVTHAAVANNQQAQAAAAAAAAHHRLMGAPAFGQMPNLVKQEIESRMMEYLQLIQAKKEQGMPPVLGGNHPHQQQHSQQQQQQQHHHQQQQQQQSQQQHHLQQQRQRSQSPDLSKHEALSAQVALWHMYHNNNSPPGSAHTSPQQREALNLSDSPPNLTNIKREREREPTPEPVDQDDKFVDQPPPAKRVGSGLLPPGFPANFYLNPHNMAAVAAAAGFHHPSMGHQQDAASEGEPEDDYAHGEHNTTGNSSSMHDDSEPQQMNGHHHHQTHHLDKSDDSAIENSPTTSTTTGGSVGHRHSSPVSTKKKGGAKPQSGGKDVPTEDKDASSSGKLNPLETLSLLSGMQFQVARNGTGDNGEPQLIVNLELNGVKYSGVLVANVPLSQSETRTSSPCHAEAPTVEEEKDEEEEEEPKAAEEESHRSPVKQENEDVDQDMEGSEVLLNGGASAVGGAGAGVGVGVPLLKDAVVS
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MPKKAGKKAGGKLAGLTEEERLLYMQQKAQAEEEIAKRKEDMLTHFLKDKLQKEEKNTVLNLHKLRQQWRAVLTQTKIAELRNDMSVLSQTFERVLDYKDNIIRSLQVDLSERELQSELKRSSHLHNVDCLLEIHKSRLAQLEFNFKSSLVELSSEYNTEREQILSQHQQECVDLDNVMFSMEKHYSDLDGEAKRDYQSTRNQIKKRNFDDKQAVKEQMDGVVEKLWQDQQQVLNHYNESTRDKIITTDDLMNKDVQSAKEIDSLKKHIQKLQDSISTFRGQLSSGQTDKTAEQLRSERDELAQEVQHFRVQLNAAQAIRKKHITKLTVQSNDATKKLQEIVARGERLLRQCEMCCKLETEHEKVLPFYKSSLSEEEQKQEKAKAMESSNEKLTQLMHDYSPLAKFWQRYNKVELDCLCVKREKLLLLQENERLRLFLKQYLDEVSVSDESFRQQKLLVVSSPALQDTAATDRHQQKRHVVQEAACIVQKQL
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNPVFLKIGPIELHYYGLMYAIAFFVGISLGKKIAKERNFDLDLVENYAFVAIISGLIGGRLYYILFNLPYYLQNPFEILAVWHGGMAIHGGILGGIAGTLIFAKIKKINPLILGDFAAGPFILGQAIGRIGNFMNGEVHGVPTFTPFSVIFNVKPKFYEWYTYYQSLSISDKANYPDLVPWGVVFPTSSPAGSEFPNLALHPAMLYELILNLIGFFIIWFILRKKENKASGYMWWWYIIIYSINRIIVSFFRVEDLMFFNFRAPHVISIILIAVSIFFLKKDNKKVF
The following text describes a protein:
Function:
The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2.
Subcellular Localization:
[Surface protein]: Virion membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM; [Transmembrane protein]: Virion membrane; Single-pass type I membrane protein.
Domain:
Both SU and TM seem to be involved in efficient transformation. The cytoplasmic tail of TM is necessary for the transformation.
Sequence:
MPKRRAGFRKGWYARQRNSLTHQMQRMTLSEPTSELPTQRQIEALMPYAWNEAHVQPPVTPTNILIMLLLLLQRVQNGAAAAFWAYIPDPPMIQSLGWDREIVPVYVNDTSLLGGKSDIHISPQQANISFYGLTTQYPMCFSYQSQHPHCIQVSADISYPRVTISGIDEKTGKKSYGNGTGPLDIPFCDKHLSIGIGIDTPWTLCRARVASVYNINNANATFLWDWAPGGTPDFPEYRGQHPPIFSVNTAPIYQTELWKLLAAFGHGNSLYLQPNISGTKYGDVGVTGFLYPRACVPYPFMLIQGHMEITLSLNIYHLNCSNCILTNCIRGVAKGEQVIIVKQPAFVMLPVEIAEAWYDETALELLQRINTALSRPKRGLSLIILGIVSLITLIATAVTACVSLAQSIQAAHTVDSLSYNVTKVMGTQEDIDKKIEDRLSALYDVVRVLGEQVQSINFRMKIQCHANYKWICVTKKPYNTSDFPWDKVKKHLQGIWFNTNLSLDLLQLHNEILDIENSPKATLNIADTVDNFLQNLFSNFPSLHSLWKTLIGLGIFVIIIAIVIFVFPCVVRGLVRDFLKMRVEMLHMKYRTMLQHRHLMELLKNKERGAAGDDP
The following text describes a protein:
Function:
Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Can also probably catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2. Does not act on futalosine (FL) as substrate.
Sequence:
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVAIQLVQHDVDLSAFDHPLGFIPESAIFIETSESLNALAKEVANEQHIVLKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDEL
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MASDKPLRLLLGFDYGTRQIGVAVGQAVTGQARELCVLKAQNGVPDWNRVEALIKEWQPDAIVVGLPLNMDGSPSEMSERAEKFGRRLNGRFNLPVFTHDERLTTYAAKGERLAQGQRDGYRERPVDALAAALLLEGWLAEHPD
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MVANGDAPARGSAAAAASLRRRRTTSGAAGGGGGASSMLQFYTDEAAGRKMSPNTVLIMSIGFIAVVAMLHVFGKLYRTSN
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.
Sequence:
MASVVTITLNAAYDLVGRLNRIQLGEVNTVETLGLFPAGKGINVAKVLKDLGVNVAVGGFLGKDNSADFEQMFNQHGLEDKFHRVDGKTRINVKITETEADVTDLNFLGYQISPQVWQQFVTDSLAYCLNYDIVAVCGSLPRGVSPELFADWLNQLHQAGVKVVLDSSNAALTAGLKAKPWLVKPNHRELEAWVGHPLNSLEEIIAAAQQLKAEGIENVIISMGAKGSLWINNEGVLKAEPAQCENVVSTVGAGDSMVAGLIYGFEKGLSKTETLAFATAVSAFAVSQSNVGVSDLSLLDPILEKVQITMIEG
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MQNDWIKCIRQEINDFKWPPSKNARICSDHFCNKDYKGYDGERKVMLKKAFPCFQDIKKVILSYLFNNFNKIVLNNYSQCHFINTTLKGGYKTLMQFSEISKYTIVTYDLGDKKSPSNFPPEGGYMKAKMDKLEKQSCAKEKRSNIFRGISIYVNGYTDPTSEVLKRLVTENGGTYQYYYLKSRVSHIIATNLPKSKIAHLRDEKVVRPNWIVDSVSAGKLIPCQNYLLYNQHSTFFDSLKDFTSSKSVMNLNTSKPSTSFLTSFENSLSPTTTTANNDVTMDVSNDEEAPAIRVKKVGNELIDDHLNDQLPAYGEADDWGEDDEEDENVSECLRSTDHLQDVSRVSNSSSANAEGDDATQLNQSSNISSEPLNRNENLREHHQHSPQPQLPPANPSIISKQSPAGGFQINNVSEFFNKSRLHHISQWKLDAKSYVTRLQKLATKSGSGGVHKFPGREKLMKLKITEEDVVPVVPNGDGDVYIPEASNGDERVYAHIDLDCFFVSVALINRPDLRGKPLAVTHLRADDANRQGFNSKSDIACCSYEARQAGVQNGMLFGHAKKLCNDLVAVPYDFEAYQRVSKVFYDVILSFTLYVEAVSCDELFVELTQLMKVTSATAEEIVTCMRKDVFEMTQCTCSCGVGSNMLVARLATRKAKPDGQHFVERGGEREFMRGVQVQDLPGIGYSLHDKLKSMNLVTCGDVLRQRTTLHQLQQTFGSKMSEADSFLADLSKEVSRRLTLINKKGKHITLKVKVRSAGAPKESYKYMGHGICDNVSRSSTLKVATNQADVISRECANLFRTFKIGIQISSLESTAQHRQHLTISSSSRPSSSLSTSTNHTNNIRKYATKMDAPLQRHITNESGADVNETLHFNDDNNNNNNNNNNNNNNNDEFSLSMSQIDLETMRELPSEIQNEIREALCNKKLKQQHQQNDVHNNIVSNNKNNNNKQNDVSDKRERNIIDSFNNVEKIQQQHQLLLLRHIFNQRRSSAQVDEASSRIESNRISLKAQTKPSFQLSVSRWN
The following text describes a protein:
Function:
Essential adapter component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, embryonic nervous system, external sensory organ development and specification of particular muscles. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Acts downstream of Notch signaling to specify the fate of the SOP (sensory organ precursor) cells and their progeny, probably via the sina-mediated proteasomal degradation of ttk. Its restricted pattern of expression, upon Notch and Ras signaling pathways, suggests that it acts as a key determinant in E3 complexes to trigger protein proteolysis in appropriate cells.
Subcellular Localization:
Nucleus.
Sequence:
MSTNQQQQANPSAAVAAPAASSEYLKRTCLICGCHTNQTINIYEPRSGPNIVQLIQAKFKFQPLNEDKFLCFSCNNWLINWHSLQAVNSNEAESQSQSPSHMGNSVLQQERTKLRPVAMVRPTVRVQPQSQPQLQPQVPINPTPAPIVYSKRRASRRSASVSRMSRVLRQCCVESLRRSPKKRNQQSVFVCLRPQGQKRSNAICKVECVAPRRKPVERLVKDVAATATPTPVLNTQSTPTYQRFPQPSVDGKVVAMFRRLGTTLSREEPAAYSAESNPACSKLPQIMSPLKEAPRWTRDLDDDEILLEFDTAISEVLPTARYQVTHEENKENQQAQEMELELEEEEEVDGRAELEVVQEAEAPLEPQSHHKQGNSHQNSHQASIQLAGLRLPMGLSISLV
The following text describes a protein:
Function:
Involved in the regulation of the cell cycle; is required for the basal body replication and new flagellum biogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MGRITTDLLRRRAEHNEGCLSNLKEVALHQQDIERIELIGDACRELEILYLCNNYISRIEGLQHLKYLKYLNLAVNNITYIEGLEGCEALERLDLTLNFVADVTCVERLRANAFLDQLHLTGNPCTKVAGYRAYVVHALPQLRELDGEEVIKTERLEARQSKDDISVAVNEEALRLQKRSVSSQRWLHEALTAFPPRYNEKGERLYGHTPEERLQMLREKEEEERRKREEQRERERSSQFGAIREELERKPQRLTAEEEIAKHGRLLLRNEPKLPFTLDEEADDGEAVVLTVKVPRFLSTTLIDVQVEVNYIRVFVKEKLIQVPLSQEVAPSGVNVQRSSVNGELRIRIPYAPHVLQEVSEARRRRQRLLGLLSDDKNEDGTG
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSVWKKAAKAHQKSHKERHQPEERKHLGLLEKKKDYVKRAQDFNEKKETLKLLRKRALNKNPDEFYHHMINSKTENGMHFEKETEAEDTPEQIRLMRSQDLKYITTKRTQELKKIEKLQAQLHLASVDHSVKNKHIYFTKNLDKDELKKKKLEQLSKKELPDVNLDDLAEAAKKKKHLYNELAKRINREKELSVIQQKIEIKRHVENRKNVLPPKRVRRGNRTQAPVYVWQYERKK
The following text describes a protein:
Function:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTIPKSSTGQSYPPVLDYRIVQLIGGGGFSKVFRAVNPSSESHSVAAIKVISYAPNRSNKYPIDRRALQKEVQVHSILKHPNVLEFLGAVERGVDKNGNAGKEKGILMGEAVATTKESIRARDKERQQMLSSPSHDQNYVPGLYMVLELGAGGDLFDKIAPDYGVEEDLAHFYFQQLLAGLEYIHSQGVTHRDIKPENMLLDAEGNLKIADFGLCSVYKYKGKERELTGACGSLPYIAPEMNGKPYRGEPVDVWSSGVVLFAMLVGSTPWDEPTSRSPEYSAYRTGKLFEYDPWPRIPQDALSLLKKMMHPTPEKRITFEGIRRHRWFKRANDLMTQKGKCNDPVNLAEKLLQGLAVSGDIIVEVNGAAAAAARRLDLHSDGQRAQVPENVSLTQPDAILTSSFDLAARAVARGWADDTGPGGGLPLPSSTAMPAFASDDMSRRLAMSQHISSRRAEFSTTASGSGYDMALPGASQFTQALNHFTQFEALTHVAGTGSSHLRFSPHLTRFFSSASAATILALIIDVLDRLAVLNAHQAIGDQEELELEEAYNFMADGEPETTVPSDDSSRPTGGSKRLLIGSRGARIRLKTMDRRKCVLRGEVYVENLAAPDSTSDSASAPDRNAAKCLVVMKKGKGDPLEWRRLFREVCRRPEIMQTIIST
The following text describes a protein:
Function:
Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9-desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the pef1 protein kinase. The pef1/pas1 complex activates the res2/cdc10 complex.
Sequence:
MSKVNMRALLESFSTVILSIYPLAKSTNQQSHSHSLSLTQFLYETIRRSRVDYTTLLLALYYFIRFRDAASSKPTNYIPLLCGRRLFLVCLMAATKFLQDRSFSNRAWSRLSGLPVDKLLVLEYMFYQCIDYRLVVPKHIFARWSLLVGECCAHATARYDSTDPNVASFGSVAQYWVSLFSNVQSSLDDLFSIACLTKIAHRRMNANAALKNQATRKPSSSPQTTQDSSPILTMAPSTPVSVGSTPPSTPSVLPIAKQLAPMNVCKAHIQASNQSRTLTTASPPEQIPLMEPQVYVNPQVLPGRLSSLSKPVSLPPTPSSPKVGVYRPMTSKSNGGVAYCYNAQKLNNATGPVTFNMPFASVLPLAVSVSCDLGTASAYVASLPQPCSQKRHLEEDYSCLTEHSAKRRSYF
The following text describes a protein:
Function:
Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGALDKDEGQASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPSRLPSALSDDIHYTPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVILFQY
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
Sequence:
MQLRLSSGNVLNEKVHKVGIIALGSFLENHGAVLPIDTDIKIASYIALKASILTGAKFLGVVIPSTEYEYVKHGIHNKPEEVYSYMRFLINEGKKIGVEKFLIVNCHGGNILVESFLKDLEYEFDIKVEMINITFTHASTEEVSVGYIIGIAKADEETLKEHNNFEKYPEVGMVGLKEARENNKAIDKEAKVVKRFGVKLDKKLGEKILNNAIEKVVEKIKEMIR