lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion matrix.
Sequence:
MASRVSRRIAQKFTKYQHSCSFWNRPRKSSLLCQRQYCSAGSASPVEGVPLTQPLPGIPQPIYAAVSHDVVHTDITTLDNGLRVASMNKFGQFCTVGVLVNSGSRHEIGYPKGIAHFMEKTAFGETEKFESRDEILQSLEEHGGICDCQASRDTLVYGVSANRGGLEDVIHLLSEVVFKPKLSDTEIEDSRQAILFELEALDMAPDPEIMMTELIHAAAYKNNTLGLPRVCPTENIPLIGRPTLLQYMNNYLVPERMVLAGVGMDHEALVDLAKRYFVNTKPTWSTPEIQEMGGRVDKSISQYFGGLQKINKDMSNIAPGTPIPELAHVILALESCGHQDSDFISFAVLNMLMGGGGSFSAGGPGKGMYTRLYLNVLNRYHWMYSAAAVHYSYEDSGIFCIQASCHPSMVRELLEVIVREFVYMAGTVEEVELSRAKRQLQSMLMMNLESRPVVFEDIGRQVLATGNRKHPREYVELIEKVTAADIKRVARRMLQSQPSVAALGDLTKLPDYADIQAGLLHKEGRLPRKYAFFRR
The following text describes a protein:
Function:
May be involved in the regulation of Rho-mediated signaling pathways and in cell cycle regulation.
Subcellular Localization:
Cytoplasmic granule membrane; Single-pass type II membrane protein.
Sequence:
MSENYSDSDSSCGWTVINHEGSDIETVTSENGSSNDNHEFVSEEYVSLQEVEQPIELQAQDSTDGEIPVVDNTLSALEETQTVPEERKEKVHDDSSCIGTISDDSDIVTLEAPKGEETPSQEEAPADGEEAPSSEDFNMGSSSSSQYAFSQPETVFPSQASDDESSSDETSNQSSPTVRRRRAKRRLISCSEAESGSPVGPEPEPPQEQQHKRQFSSGLNRCIILALVIAISMGFGHFYGTIQIQKRQQLLTKTRELKDDLYQCQQEQGDKVGSLKGDLATCLTSTEVEKKSFESQKKSLAAENQHLRESLEKEEKALVSLQEELRKLRQQIRNLEDKGTSTESIVMENQKLREHLEEEKQRNHNFRRQKETLFAEAQMLRRELDKERHVTEALKKELEQLSSRQTPDSVNDDDTLRENEEIETLRGRLVELEKKLNFEQQRSDLWEKLYVEAKDLTEKQEMNEKGQKRGAKGQSKSKKKSKESFFGSVKETFDVMKNSAKEFVRHHKEKIKQAKEAVKEKLKKFSDSVKSTFRHFKDTTKTILDEKEKKPNEKKYEANKKARTFYREHNLYENLKQSHYRRPNVPKDFRDGRRHHFTAFEKDTDSQKCLNDPLCSRKHQFDLKGCSGIFECANQEFVSLFNRVSDPIGVDEFNRLMRKYLQQVVHNFRHWRELENFINKFFHNGFFIHDQMLFTDFVNDVKDYLEDMKEYQNKNEKVFDDLDKYIYRYYFQYDNSPQYGPSRPKRPSFTQTENPRHEKQAQKYHHRNKREGKWHKHGRTNGRHMANLEIELGQLPFDPKY
The following text describes a protein:
Function:
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFIFSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILPTLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFCYGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGINYTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRGIEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCVMLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQAKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKSEGGNKVIIHHI
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Sequence:
MQVASLEMIHTHFGPASVDNYQPQTLYQQQQKRKQQEQQHQPSQQQQQKQQDQLHPQQEEQQQQEQQQQQEQQQQHEQQQQQQQQQKQQQQEEEHHHSQQQQQQQKQQEEEQQQNQQQQQHISTIICNPPPSIISTSNGTTMCVAKLMIGLDHAPPAFNVRSRVLGDGGTNLNYIRTETGAIVTLRGRGSLNLEPQTMQEAPEPLHLFIEHPLLDGLQNAKQLAKNLIETLQEELSFFQENTIPKANFRLMPQPSIVQTNQVAQMPPIIRTQHVTQPNGIIHQPPPTVLGPPLPSFVQHPPALQQSQPPPPQIIQQPPTIIQSHVPLQIHQQPSNVVISQIQTTAPQSQIPNVSNPPPGTQIRPIVQIKNTPAGTHLTQPPPSIQIQQAPPEAAQQIIVNPAPPYQVQYIQQNPSLQTASGPHSSGQVTIQHLIQPQSQPVQGIVQTTIPPPQFDHFQRPPQTQQIITVQGSTAFMVPPPNIIHQTAPQTPNQIIFQTQQPILTHPPPELTPLGPQAGIILNGAEAKKVVGSTEIKIKPEPMKLDDGPSTGAILQQIPTNSQLAKTTVIPVSSIAGIPISQPPPPIMSVPPPTVQHIVGNTIITSQPNPPISHGGISQQIFSQIPVSIQSFTPATPPQQLQVSGSHFVVSAPQAWPVVTASAAGQQIQQLPVSTVPSIQITTQPMRNPNEIHIISQPTIISAAEYRPPASQQQQIIANSSFNPQIQPPQGVQVQFHTVPPPPQQIITSLGNAQIQHPPQAPQSQLIENQRAPQHQIIINASIPPQPPPPPPFTALQYSAQEVSKPNVEQLQRPPPTPHPPHKQLRHNINTQTKPHAMLRPGQKRKISDEDVNKLMPPKIGLGTIFSAKSPD
The following text describes a protein:
Function:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection.
Sequence:
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAEDPTAPALNLSPEEKRVFGQLFRQADTENIGVVTGEVAVKFFEKTRLEPRILGEIWQIADKENRGLLTPAGFGIVLRLIGHYQAGRDPTPELALRPGPLPKFDGGLVTPTPTFQPPPGPPPAALQPQPSGSGPIRVPPLSAEKSTQYAQLFEKSGAQGGILPGEQAKQIFERAGLPNEILGRIWNLADTEQRGALTSTEFVIAMHLLASFKSGQLRALPNILPAGLYEAAARRGPPNRQSTGNNISAMPRQFSGQHGRANSPLSRPAYATPQQIPQPTGSEWAISPVDKQKFDGIYHTLDRTGKGYITGDEAVPFFSDSKLPEEVLAQIWDLADINSAGHLTMDEFAVAMYLIRQQRAAEDLFGLDALSSPPAPVQAPQSTGGSASFGPNRQLLADPFGASAQPLAPSSPVQQSPQHTGSVFKPFVPSSSFGHTLTAHLTGGSNNSAPNRAFSQQPSVSEDLLGDNDPEISSKLTNETTELANLSNQVGTLSTQMQQVQSQRSATQNELTQADSQKQQFEARLGQLRALYEQEVKDVRSLEERLNASRNETKKLQTEMAMLEATYTDLQTQHRQIVTALQADQQENASLKERMRVVNAEITQLKPALEKLRSDARQQKGLVAINKKQLATNESERDKLKGEASDLTKSIEEDTAALAAAARARSQSPVQARAQSPASVASPAPSTMSANNPFFKRQATGGSNTDMGSAFAASPVQQTDRSFENVFGPAFGSALPHPETAAPPTSFKQDLPTRPQTSGGFSTPSITGEAPPPMPASRQISSSFLPFPTHDDSISSSRQVSAPNSRFGDNSIGGETPTNYMGTTPTGSSITNQAEPVVTARAVSPDIDRRSTASPAVTESKDSIPGAFPGDDNSNIVATPTGGTTLSEQVAADPFATTKEPVRSGTAKDDFDAAFAGFGNSSKAPERSNTGSSAEPSAATAAPSGFGQEFPPISELENDDESDSASEGGFGGGGFDDDFNPASPAQVRKAAESPALPHTAASTTGGAKEFLNAATPAATAGGDPPTPNAQASPPAYDKAVSPADQAHSEVQQYSGLLPSREVPSPEHPTSSATAAPQTSSQPAPPAKVPFDDDFGDEFDDLEDAKEGEADDEFANAASSIHESRNGLDDFNPMFDSPPASKHQDQSGNSFGGDASGFGDFTSSAKPTTAGPPAVNDNHDWDAIFAGLDGPGGDASASAAQGNGNGTTSNDNSMAGGAPTGGDRPQVGRALTEAGEHDDPILKNLTGMGYKRNDALAALEKYDYNLERAANFLASQS
The following text describes a protein:
Function:
May function in depolymerizing pectin during pollen development, germination, and tube growth. Acts as an exo-polygalacturonase.
Subcellular Localization:
Secreted. Secreted, cell wall.
Sequence:
MANARSLVAKANNINVGSLILMALVFGSCVANGEYLGGRRGLAANSGNPTVYDITKFGAVGDGSTNTFKAFLNTWIQVCDSPVPATLLVPKGTFLAGPVIFAGPCKSKVTVNVIGTIIATTSGYATPEWFLFERVDNLVLTGTGTFHGKGEAVWKADGCGKKVQCNLPPTSLKFRNMKNVEINGISSVNAKAFHMFLVKTENVNIQNIKLTAPAESPNTDGIHLSNADNVSILDSTIATGDDCVSVGRGSNNVTVERVICGPGHGLSVGSLGKYKNEEDVSGIHVNNCTMIETDNGLRIKTWGGSDPSKAVDIKFENIIMQSVKNPIIIDQNYGSRGGDSQVAISDILFKNIRGTTITKDVVQIMCSKSVPCQGVNVVDVNLDYVGKTGGEKKSSSGGLVGALCDNANVIFGGKLSFPMCPK
The following text describes a protein:
Function:
[GLV6p]: Signaling peptide (root growth factor) required during root gravitropism in a PIN2-traffic dependent manner. May be involved in maintaining the postembryonic root stem cell niche. Root growth factor that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells (By similarity).
Miscellaneous:
MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
Subcellular Localization:
[GLV6p]: Secreted.
Sequence:
MKLIRVTLFLCALAILLLVTPTSSLQLKHPYSSPSQGLSKKIVTKMATRKLMIISSEYVMTSTSHEGSSEQLRVTSSGKSKDEEKKLSEEEEEKKALAKYLSMDYRTFRRRRPVHNKALPLDP
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MNNPMIKNGLLLALFALLCTGLVAVVNQQTFDKIKLQQQKELMGILHQLIPEEIHDNELTAQCTLLQNKEALGTEDAMPAYIATAAGKPVAIAMEAIAPDGYNGNIKLIVGINTQGEVLGVRTLAHQETPGLGDKIELRKSDWVTKFVGKVLKSEDDKQWQVQKDGGDFDQFTGATITPRAYVKAVKRAVWYFTQHQAEIFSQPLNCEAKHD
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEMMNWERRSLLNELIHGLKAAKQLQGSSSPSLSASSSYLTTEIKENLLHNIVSSFKKAILMLNGSTTQHNPTIELAPDPLAHPGKVPGSPASITGNPRSEEFFNVRSKEFNLSSKKRKMLPKWTEQVRISPERGLEGPHDDIFSWRKYGQKDILGAKFPRSYYRCTFRNTQYCWATKQVQRSDGDPTIFEVTYRGTHTCSQGIPLPEKRETKPKHTVAVNYQNLRASLTVRTGGLGSEAFSFPVTSPLYTYESINGGGTFYHHVGSSGPSDFTGLISTNTSTGSSPIFDVNFQFDPTAEINTGFPTFFHNSI
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MAKKYYAVKAGRKPGIYNSFAECDKQTERFPGAEWKGFDDYDKAQEYMSWIGDAGLSTRMLVQLVQDTTADIHLFKINVAVKTDALEAALKNLEVTQRDLEAAQRDLEAAQNQLQEAELDLRVAQKKIQAANSQKNGGQMFFVCENLIFDQEREAMRSAAQKFLPIESFLSLEEAIGYVEEETDYALVFPPEQRGLHYSNSDGDIINQIFTDGACSRNGQKDAVAGFGLYLGENHKENLSGRVYGSPQTNQRAELTAILHAYCICASKLSDGRLYEIYTDSSYAIDCLTKWHIAWERNGWRNRGGEPVANQDVIKRILTLKAESTNCIGLKKVEAHGSSEGNKQADRLARQGVTAKNLFENIPNWFLNR
The following text describes a protein:
Function:
May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation (By similarity).
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MSTNNCTFKDRCVSILCCKFCKQVLSSRGMKAVLLADTDIDLYSTDIPPTNTVDFIGRCYFTGIHKCKLKDIACLKCGNIVGYHVIVPCSSCLLSCNNGHFWMFHSQAVYGINRLDSTGVNFLLWGNLPETEECTDEEMLEISAEEYIR
The following text describes a protein:
Function:
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPAKRIAVIGAGVSGLAAIKICLEEGLEPTCFEGSHDIGGLWRYEENCAPGKSYSVYKSATCNTSKEMTAFSDYPFPDHYPNYLHNSKLMKYLRMYVKHFDLLKYIHFLSKVCSVKKSSDFSSTGQWDVVVEADGTQEFYVFDAVMVCSGYYTDPCFPLENFPGITSFKGVYFHSWEYRSPETFLGKKILVVGIGNSGADVASELSHVAKQVFLSTRRGAWVWNRVWDNGNPMDTVLFTRFNSVINRILTTSMINKWAENKLNSRFNHDVYGLQPNHRFLSHQATLSDDLPHHIISGRLRVKPNVKEFTETAAIFEDGTQAQVDVVIFATGYTFNFPFLEGNSEVLDSQCSMFKFVFPPQLEKPTIAFIGILQPMGATIPVSELQSRWATRIFKGLNKLPPVSDMMATVKQMKDKIGKKFLKSPRDARRVPFVDYMDEIASEINVKPNLLSLFLWDPKLAFEVFFGPCTPYQYRLQGPGKWNGARKAILTQRERIIKPLRTRVLSNDKPSFYLSFWFIGICVSILFFLIFIIKI
The following text describes a protein:
Function:
Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T) (By similarity). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity).
Miscellaneous:
MISCELLANEOUS: In TtuA from T.thermophilus, the sulfur inserted into the nucleoside comes from the C-terminal thiocarboxylate of TtuB, but there is no TtuB ortholog in M.jannaschii; MISCELLANEOUS: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.
Sequence:
MVKTMKCKFCDKKSYIKLKSPKMYLCKEHFVEYFENKVKKSIDKYKMLSKDEKILVAVSGGKDGHAAAWVLKKLGYNIELFHINLGIEGFSEESLKAVKELAEKLEVPLHVVNLKDITGKTMEDIRGKKCSICGTTKRYLMNKFGYENGFDVIVTGHNLDDEVSFILNNLFNWNIRYLAKHEPVLPAHDKFLKKVKIFFEIEEELILKYAEAEEIPYTTVECKYAERAITLKHRAYLNELEKERPGIKYQFLSGYMKNRHLFKVEEEDFQFRECEVCGMTSAGKICSFCRVWKLYKKKKENRN
The following text describes a protein:
Function:
Has metalloproteinase activity. Proteolytically cleaves the PGRP-LC receptor; involved in gut-fat body innate immunological communication (GFIC)-mediated activation of the imd/Relish signal transduction pathway. Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue. Required for growth of the dorsal air sac primordium and development of the dorsal air sacs. Promotes embryonic motor axon fasciculation. Cleaves and activates frac to promote motor axon bundling during outgrowth. Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites grow. Involved in inhibition of follicle stem cell proliferation by cleaving Dlp, inhibiting its interaction with wg and preventing Dlp-mediated spreading of wg to follicle stem cells to enhance their proliferation. Plays a role in wound healing. Involved in fat body dissociation which occurs during metamorphosis by degrading basement membrane components, leading to destruction of cell-basement membrane junctions. Required for posterior follicle cell degradation and ovulation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MFSKYVLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEGEETGRSGSRELRINHFILSILLLAIANWRS
The following text describes a protein:
Function:
Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (By similarity). Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance (By similarity). Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation (By similarity). This is a non catalytic metalloprotease-like protein (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLPGCIFLMILLILQVKEKVILGVEGQQLVYPKKLPLMQKRDIGHTHDDDIEETYEEELMYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHLQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRVNDQRYLIEPVKYSDEGEHLVFKYNPRVPYVANYSCTELNFTRKTVPGDTESEGDPKMKAIHNEKYIELFIVADDTVYRRNSHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELHSNIETTLLRFSSWQERILKTRKDFDHVVLLSGKWIYTHVQGISYPAGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPCNFDDFQFCGNKKLDEGEECDCGPPQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAEDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTRRDQCSELFDDEATESHDICYKMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSYLLGEDKTYHLKDPQQNATVKCKTIFLYHDSTDIGLVASGTKCGDGMVCNNGECLNMEKVYNSTNCPSQCHENPMDDHGLQCHCEEGQAPVAWEETLNVTNVAILIVVLVLVIVGIGVLILLIRYQKCIKLKQVQSPPIETLGVENKGYFGDEQQMRTEPILPEIHFLNQRTPESLESLPTSFSSPHYITLKPASKDSRGIADPNQSAK
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Also involved in the transport of mRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus.
Sequence:
MVKLKIRAVQPPPNDSRSSTPATGPPPPIPKIKIKTREPKGPRLTKIRLKRVREPGLGYDSEASDREEDTYIEEQIILRLPPGEDCEYVRKAIENREVGRGADIWVKFKDQRRAVVHVNGHLYAAKLVDLPCIIESNKSFDKKVIFKAADICQMLIATERIEHENSVLNTQLKQADYIYPHGLTTPMHWVRQKRFRKRVSNRTIEAVENEVDRLLAMDERAESTSNELIDQAQLARDSSIALSEDTSFDGMAGLRGTSIDRDDQSVQTDMFDGMDEDDLAGQIEQGMLELSQDTRESTAEPRAAGEESASEEEEEEEEEEEEENEADDETRENKRQNRLVREFISELESSIQKRRKDADEATNPILRNRFLADVNRMVTELELKRTQLVDNPE
The following text describes a protein:
Function:
Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes. It is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (By similarity).
Subcellular Localization:
Peroxisome membrane; Single-pass type II membrane protein.
Sequence:
MKNDSSTSAAPMKGLVGPLRSSEPARALPAVPPAVYLLEEAADLLVVHLDFHAALETCERAWQSLAEEPTSGTVVEVKCSLCVVGIQALAEMNRWREVLSWVLQYYQVPEKLPPKVLELCILLYSKMREPRAVLAMADAWLQDPDNQGLPEYGSLAELHLLRVLLPLGRLSEAEGLAVGSAAFSEEQREAVLQAICTARQQHTREHLSSQEQQQMSQEGSFSHKLMSLLRLLRRLWDAAASHLLSQPFKKSLLAALILCLLVLRFDPATPSSLPFLYQLAHLFRRIQKATLSRLYPLALRD
The following text describes a protein:
Function:
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MGRGGRGGAAWVRARGRCALGAAAAPAAAAAAAAAAAAAAAAAARAPRSPRPAPRAPRRRPPRPRRAPIPAAGPGRARSLGAGCPRCGPAAMATKIDKEACREAYNLVRDDGSAVIWVTFKYDGSTIVPGDQGADYQDFIQQCTDDIRLFAFVRFTTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIKSELKKAGGANYDAQTE
The following text describes a protein:
Function:
Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
Sequence:
MATEGLAGALATVLGGKGLLVQSCDSEPAGKPLFPVRLRKNVCYVVLAVFLNEQDEVLMIQEAKRECRGTWYLPAGRMEPGETIVEAMQREVKEEAGLLCEPVTLLSVEERGASWIRFVFLARPTGGVLKTSKDADSESLQAGWYPRVSLPTPLRAHDVLHLVELGAKFCQQAMHPLILPQELPCSVVCQRLVTTFTTVQSVWVLVGTVGTPHLPITACGFTPMEQRGGIKVAILRLLQECLTLHSLAVETKGLLGLQHLGRDHVDGVCLNVLVTVAFRNPGIQDEPPKIRGENYFWWKVLEEDLQKLLLYRLQESSVIPLSR
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDAFDFLETLPTATLERLYQDPWACQALFQALPPLAQQFVMRLLPSNAAVPRALLEQWVVPEPGDAKRMPPQFHAALHKLEGLRVFVQQDGAYRPHPTFQKQLMVKKYEQCYHYALSNLGGSPWERGRLQLPKDPENTYAAADLERYARARWDSVLHYMVGSTAVQEPPQSVVDILLRTKLLQSSGADSRALHITDTGYEFMLKDIHVQMWIFMLEYIRTLDNTGTLKQEDILQFLFQISYCQTGEYYAVADLTETQRLLLGDFIDFGLLFRKRPTSDRFYTTSLAVNLIFGGSTGQKRSQVSLTSSFAGVRAGVKSQVADPRHAPTADHGAQLLVVVETNFKIYAYTTSTLHVAMLSVFVDIVARLPNMAIGFITRESLRSALIHGISAQQIYDFLMKHAHPKMRRNTPVIPENIADQIYLWERERNRVQFLEGILFDGFNSKEDYESVRDYAEDLKVLTWMDPIHFRLSIATAGIDDVRHYIQTQLSSRS
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular Localization:
Nucleus.
Sequence:
MDEDINKDTNNNNNTTDSNNNNNNINEDEIIFNNYINNYSNYLNNNGISALDLLIQGRDGNNNIITFCSEIDQMLNGGTPLKKITEICGVPGIGKTNMAFQLLVNTSIPFDLGGVQGKAIYIDTEGSYSCQRVREMATHLVNHLECVLLKNPMTQTTYIPTVETVLNSIYYYRVYHYIEIISLIHQLPLFLEKNKDVKLIVVDSITYPFRCDFKDMGLRTRSLLSLAQNLMNIATRYNLAVVVMNQVTTKISPNQKESILVPYLGESWTHICTYRMVLFWKQKQRFCHLYKSPSFKSCFTPFDIVEYGIRDVGFNHPPPLNPEDQEQEKEKEKRKKKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNDENEMYIEN
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MVVRKVGKYEVGRTIGEGTFAKVKFAQNTETGESVAMKLLDRATIIKHKMVDQVLASRTKIYIILEFITGGELFDKIVHHGRLSEAESRRFFQQLIDGVEYCHSKGVYHRDLKPENLLLDSQGNLKISDFGLSALPAEGVSILRTTCGTPNYVAPEVLSHKGYNGALADVWSCGVILYVLMAGYLPFDEMDLTTLYNKACHKLLLLLLSVLLDFLYQGRIILVVCLFVQIDKAEFSCPSFFPVGAKSLIHRILDPNPDTRIGIEEIRNDEWFKKNYVPARVVEYEDVNLDDVNAVFDDSEEEGGGDEQQTDEDACPLSLNAFDMIILSQGLNLSSMFDRGQDPVTHITRFVSQKPAKIVLSSMEVVAQSMSFKTHIRNYKMRVEGLSANKKSHFSVILEVFQVTSNFVMVDIQKAAGDGAEYLKFYKNFCNNLEDIIWKPPNEQQQQQHGKSKITKTKSKRR
The following text describes a protein:
Function:
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. May act as a regulator of multipotency in embryonic stem cells. Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MDVGADEFEQSLPLLQELVLGADFVGLDIEFTGLRSNLSRPQQISLFDLPSEWYLKTRHSVQQFTICQIGLSVFSSIEGESNKYVAHSCNFFLFPTTFGILDSEFSFQASSVQFLNQYGFDYNKFLKNGIPYMNEEQEKKIKHNILTGNWRVRSSLDKDQIKVVIDEVTRWLDLAEEGDWMTLPGIAGFQAFEVQLVLRQALPDIWTVLRDQGIIVKKVSKQHRWYLENTSCDRESCWKEKILLSARGFSVFFQMLVKAQKPLVGHNMMMDLLHLHEKFFRPLPESYDQFKLNIHNLFPILIDTKNVTKDIWKELNFPRVSNLSEVYEVLNSDLNPTKNSGPVVIHASKCEKYVETKYPHEAAYDAFLCGSVLLKVAHLLLWRVHSAGPMPEPSFSLYLDVLAPYVNQVNLIRAGVPKINFSGPDCPSIRPPILLLRVRRWPGVSEQQVYREFQNVCKFDVRRLSRSQFLLLTNKFKDARSILKEYRGHPTLQVSLYRYWRHSPNINCLLQVCGVVTTWALLALLLGRPGP
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MASGGKGLNATGEFFRRRDEWRRHPMAGNQLRHATPGLGIAIVAFGIYLVGEAAYNRLYRPSGDNHH