lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase PolG1/tam at the replication fork. Promotes PolG1 activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate PolG1 activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MQHTRRMLNPLLTGLRNLPARGATTTTAAAPAKVEKTVNTVTILGRVGADPQLRGSQEHPVVTFSVATHTNYKYENGDWAQRTDWHRVVVFKPNLRDTVLEYLKKGQRTMVQGKITYGEITDQQGNQKTSTSIIADDVLFFRDANN
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MGDELTAQAIENDANYDERLAKIRASNEIDAKYGYENYTQPQERVSWLVNIAVAEMVDEHTKVILSAVDFYFLEESGKRLKITYPFRPYFYIAIADNFDLQAAAYLTKKYNFIHVEHLEKEDLDLKNHLSGLRAKYIKLSFPSTAELQKVKKDLMPLVRKNSEKRKEDAEFATLLAKQLGGVTDETINDDVLTKFIDMREHDVPLDCRVSIDEKIFVGKWYSIVGMGKDRKPSIKDHARGALEPVDPIVLAFDIECTKLPLKFPDASFDEIMMISYMIDGQGYLIINRQIVSTDIEDFEYTPREDIRGNFAIFNEKDETDTIKRFFTHILSVQPHVIVTYNGDFFDWPFVEARAEVRGLSMAREIGFEKNAQEEYKCRNCIHMDAFKWVKRDSYLPVGSQNLKAVAKAKLRYDPMEVDPEEMCLMARENPQALANYSVSDAVATYYLYMKYVHPFIFALCTIIPLGGDDVLRKGSGTLCEALLMVEAFHNNIIFPNKFTGKEEAQWTNDGHKIESETYVGGHVEALEAGLFRADIPTRFRLVPAAIAQLSREAGDTLEKELVREYSLTRENVTNWDEAIGEVTKQLDALLLHPARLEKPRIYHLDVGAMYPNIILTNRLQPSAIIDDSTCIACCYNTTDAKCKRKMAWEWRGELIPASRGEYERLLRQLEGESFGRPPRPFHTLKKEERIKLEKKRVQDYCRRVYGKQHITRNEMRESTICQRENAFYVDTVKNFRDRRYEYKDKLKKAKAELDKADKDDLSATKRAQGMCVLFESLQLAHKCILNSFYGYVMRKGSRWFSMEMAGIVCHTGANIITEARKLVEQIGRALELDTDGIWCLLPQSFPENVTFELQNCAKKRVTISYPAAMLNAPYHNLQPDGSYSISKENSIYFEVDGPYQAIILPASKEEGKKLKKRYAVFNLDGSLAELKGFELKRRGELNVIKQFQSGVFRNFLRGNTLEEAYESVAREANYWLDVLFSRGVDMNDAELFELIGENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDDVVKEAGIACHFVICKYPLDAPVTERTIPLAIFQAEPDVRAHFLRKWTKIQSITKDNVNVRDLIDWSYYIERTGGCIQKIITIPAALQGVANPVPRIAHPDWLDNKIRKKVDAALQPKVTDHFTILSKDQKRKQMEEANETAKRRREEEDEEEDGEEGDKENRGGGAKRKKGADDEEIDENVKIVSMASEGVLPWLRSLHKQWRMQRKQAKLRKQRAEAAERAGERGGGGGGGTPMGRGTAAAGSLLNHMRINETTIWQVISLEESRQPGVWYAWVTNGGRGGGRCERVSVRLLRSLLVNRRDKRSGTGEDHIRRILPRGHPIHFLYQHKVEETRLHELKGKLQREACTPTIEGIYESEVPPLLRLLSTMGCAVEAKLEGGSLNPDNARRVTVPEYLGEGQKISSVFYYKYTQESRGIVAVLCAATAEGVVISVGAGAMPNMTNMYSSIFEEMDSLPPDVEATMQVTIKTSKTMEDADKEVEKWLRKRLSSSSRMTILCCIAEPPALNTMRQLAVMPVIPLNQKEPRGLLSTIDYQRIDFINWARFLAIPIGNIPSDTVQMGLDVLLARHLDRAGHVSWASAAARPDLGGKESLDVRLAYEWRPLDKDMTTLICRPTMCTEYCVDMQVDALAVNAVVQRGYLMEAEGLDEVLHLEGGEGTSVDDSVRILRHMLSELVREIAVNKSHRADELVIGLRRWLTTPSSLFFDPLLARYVATLEKKLALLLSTEFSRLGAKIIYASPSRFVFSTGKKNLSEAEAFMALLKSSLSSTQLFAAVHMHVTRMYSALLFKDNKNYAGVVEKRREDYEREAEEISEEVDEESAAAPPKVEARWRMAEELNEMGDRVMDEYDNVVNGYVLITKQRIMENSDPNWLLDQRQRIIRNDLLTRLLRVTERLLRQGADGARAAGALTRAVCDAVSVDAEVADDVASIREQLQKVVASTPQRVHPLYLSDIVCACGQPMDEVDISDPSTWSCGGCSKTVPLSEMEERVVTQLQETLTLFLVQDHRCIKCGQIRRENISMLCDCSGCFTNTLDASSFSTLLSRMAIVAAEREMEQTAYAVRWIQSVMGV
The following text describes a protein:
Function:
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.
Sequence:
SRQICIFLLSTYTGGEPAESARWFYTWLQDTVSDFRVQKTLLSKLNYAVFGLGNSVYQEHFNSVAKDTDSWLHKLHGNRILPLGIGDNNVVQSENGGLEEDFVAWKGRILRVLNLEITPSHKPVDNEVNVAPSKIKVKENVIHEGKITSESSDNSEDEETIAMKKNSTIPIKNDVVDVEDLGVMLNNLGKAKADRELEVSTLQRVQAGPKTSISSLKKAELRDMVTPSLKEALSKQGYKIIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDDPEKIFNEALKNHYGLIKQFKGKLGHLRIRTIILFCKHNGKNLTDFLGVPGVQTERFKEAMEVKHCALSLVGEPIMYPEINKFIELLHGKEISSFLVTNAQFPNAIRDLTPVTQLYVSVDASTKESLKKIDRPLFKDFWPRFLKSLSALSEKGQRTVYRLTLVKAWNAEEIEAYANLVGYGNPDFIEVKGVTYCGESKASKLTMENIPWHQEVLSFTDKLVDNLPEYEIACEHEHSNCVLVAHKKFKVHGRWHTWIDYAKFHKLIAEFASNGGKNFDASDYMALTPDWAVIGHPAHGFDPVETRWHRKKNNKDIGGC
The following text describes a protein:
Function:
Pole-localizer protein involved in the regulation of several cellular processes. Regulated processes include sugar metabolism, cell motility and small RNA-mediated regulation. TmaR controls the subcellular localization and the activity of PtsI, the general PTS system enzyme I (EI), by polar sequestration and release of PtsI. Polar sequestration of PtsI restricts its activity, thus regulating sugar metabolism and enabling cell survival in mild acidic conditions. TmaR does not affect localization of the phosphocarrier protein HPr. It also plays a central role in cell motility. It controls flagella production and, thus, cell motility and biofilm formation, by forming condensates that protect and stabilize flagella related transcripts at the poles. In addition, TmaR affects small RNA-mediated regulation by recruiting the RNA-binding protein Hfq to the poles during certain stress conditions. It plays a crucial role in Hfq condensation.
Miscellaneous:
MISCELLANEOUS: Overexpression of TmaR leads to the formation of chained cells, suggesting that the cells cannot complete division. Overexpressed TmaR forms filaments.
Subcellular Localization:
Cytoplasm. Note=Forms clusters that localize mainly near one pole of the cell. Forms condensates at the cell poles in an RNA-dependent manner. Phosphorylation on Tyr-72 is required for the formation of polar clusters. Polar localization does not require PtsI.
Domain:
The two helices, which seemingly fold into a coiled-coil, and the C-terminal region are probably all necessary for TmaR condensation.
Sequence:
METTKPSFQDVLEFVRLFRRKNKLQREIQDVEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKGDYEDRVDDYIIKNAELSKERRDISKKLKAMGEMKNGEAK
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MGDNSVVYWYSSLEKHLCGYCKNPKGNVSHGMWAKILSVEDYQNLIDRGWRRSGSYCYKPLMNEICCPMYTIKCDALNFQLSKSQKKVIKKFNKFLKDGVLNKNTNPQECQDNISEFVHREVPTHVLDKEVVINSDLNCEKDEQDSSQVAAPSVSQVQEAVPSTSSMPKSGLGADPTKPPCKKAKILRLERKKEKLQKKGIVFEKKPATNEQKTLEEFLNDTAPDSKHKIKLVLINTSRRSAEWENLKKLEFELYKKYQTCVHNDPPGKCTMEGFQRFLINSPLQITLEQIHEKHKYFHLTASLFAKYQMAVHNEPPGDCDEDQYLNFLIDTPLQNVRFSRDSELGFGSFHQLYWLDDKLIAVGVIDILPKCISAVYFFYDPDYRDLTLGTYGSLREVEFARTLHRIIPSIDSYYMGFYIHSCPKMRYKGKLSPSYLLCPETYRWISIEKSVAKLEASKYSRLDNNEAVDENSCTSRDVDEIKILCNRKLVQFKQYKRKFGGHDMFDTIGRLIGKKCAKSIIFIADN
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MTTAHRPTFDPARGKEALRGPAYHQRLLPAYTHLKVRQSGQGTEGEAARRDLRAELLQAEAAHFAKKNGAPVPEASAESTPKRQLEGAPANGGDGELEEDPEAKRRRILEETREIDADSEASEEDSSEDESDDEDEAAELMRELEKIKKERLAQKEKEERERAAKEEEQREVDIARGNPLLNPSDFNIKRRWDDDVVFKNQARGTEDKRGKEFVNDLLRSDFHKKFMSKYVR
The following text describes a protein:
Function:
Putative 2-hydroxyacid dehydrogenase.
Sequence:
MITSIDIADVTYSAKPRILVPYKTQWEVASHLPEYRKLAERVEFYKYEMSTKDDFVKFLETHRINGFWLTEEFFTVLGNPSSYIEFFPASLKVILVPWVGCDFIDGKLLRSKGITLCNIGPHAADHVTELAIFLAISCFRMTSFWEYCFKYVENGNVEQCKKYISSDSYEIVTDSYHGQEMKFPSRTDKCKPNKDRKVVHLAEKYTVGGKKMESPMNKKVLILGFGSIGQNIGSNLHKVFNMSIEYYKRTGPVQKSLLDYNAKYHSDLDDPNTWKNADLIILALPSTASTNNIINRKSLAWCKDGVRIVNVGRGTCIDEDVLLDALESGKVASCGLDVFKNEETRVKQELLRRWDVTALPHIGSTVADMVIKQTLITLENVQDIFVEGGDGKYVLN
The following text describes a protein:
Function:
Involved in the latter stages of the biosynthesis of the alpha-(1->6) mannan core of lipomannan (LM). Catalyzes the addition of alpha-(1->6)-mannose residue.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTTPSHAPAVDLATAKDAVVQHLSRLFEFTTGPQGGPARLGFAGAVLITAGGLGAGSVRQHDPLLESIHMSWLRFGHGLVLSSILLWTGVGVMLLAWLGLGRRVLAGEATEFTMRATTVIWLAPLLLSVPVFSRDTYSYLAQGALLRDGLDPYAVGPVGNPNALLDDVSPIWTITTAPYGPAFILVAKFVTVIVGNNVVAGTMLLRLCMLPGLALLVWATPRLASHLGTHGPTALWICVLNPLVLIHLMGGVHNEMLMVGLMTAGIALTVQGRNVAGIILITVAIAVKATAGIALPFLVWVWLRHLRERRGYRPVQAFLAAAAISLLIFVAVFAVLSAVAGVGLGWLTALAGSVKIINWLTVPTGAANVIHALGRGLFTVDFYTLLRITRLIGIVIIAVSLPLLWWRFRRDDRAALTGVAWSMLIVVLFVPAALPWYYSWPLAVAAPLAQARRAIAAIAGLSTWVMVIFKPDGSHGMYSWLHFWIATACALTAWYVLYRSPDRRGVQAATPVVNTP
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MPVRALWCSQYNCSGLPAGGVQRVGFVQSAGEKSLLACSIKSRISAKAQMDSEMAEEDSEEVEIDLSDSNESPELEKEEETQTLWKAQPSVEEEENIHTSTLVEISDTKPLIKTRDPRGINDCLKVTFEDVIAEPVSVRSGDRVWIWSNALFEVSRVWLYRILTVVLAIPMSVLSGVLFAIFSCFHVWMVGPCVEYVLIGTRWLQSLWNVVLGVFVLPFSRTAKRCCGGFSIHLAEE
The following text describes a protein:
Function:
Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MHCDGAIRNIEKEILRECAYKGIQVHENFLNYYLKLLSLDPTWGITGKDVLDRSDVQNFIKYVVHQLENQNTPSMITLKMQFYFTCNFQMKQKMVKRNRTELLMRLRGLEQEIIDVKYLTEEDEINLMYKKIVYYITLASGLGNPTFDAVFKEVRVALGSILDRNELNDFVAQPRFTKIDNLAEFTKLVTGIRLFNKDCGKGGEGMEDLPKLINEALIATNAELQNTLISIMDKVNLMTTALDFVCGTEMDERHNYVIAYRLPKGVTMADVNYVKDSLIAYRQHELYVRKMMDEIDRIESTSAQIFTILQRALIDLHRVVKHRIAIPVNQVFPHFIKLSDIWCNLQDQTILLAKHNQIMMNLQKYIKVLSFPDSIAEMMIPPGESPMTDTERLQKTADQKIPQEDNHSMVLDPLLYTDLNKLKYEYLGFCAWKIFMTEGALLPGNPGLGIAKTMNMQFVFSSVEAGIAFGKCPEKCVMETIKLARRKPELINLLAIKDRLILVQNIRDLVHEPPLLPLTDEVEVQTEMHPVESNIDRNYFWNVWDLRRKAIEYANLTHCQTVSCQTKKSYYRFNSKIQTCDPRDKGAQTKRDNYTNVPKPSTYIFGLRGRKDDKQFIVDLTRPVEE
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSRLSMLRMLSPRGLLVASSAHAVTAVTTPIAKASAESEKASPPDPRTTSILADIDQLSRNGLAQRVEMPTELLDRLTSAVRSRTHSQLEALRQKHVGDPRNKRLLPLDMSKTSLGWTMDRSQQIPPFAYGPAETLAFLAFEMEATYACTHAVFSELQKRLPDFEPKSVLDFGAGPGTASWVAKDFYDKSLDKYRVVEPSQSMVDAAEVLLDGFPGLSMRRSIADMSRDIDAGNKYDLVVVSYVFSDITNDFERVATTSALWELLSENGCLVVVDRGSPWGSHQVRSARQFILDSVAEDEDAKEGTRIIAPCPHHFECPAAGSTWCHFVQRSPVVNRPREATTKRWHGQKGSKFSYMIMQKTSKGSDEDAAAKKKKPIARMLRGPLLATRHVHLDLCTPEGKLERRSVTRGKSIREVYRASRKAHWGALWPADEASYRKNE
The following text describes a protein:
Function:
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Subcellular Localization:
Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MKLNERSVAHYATCNSPPDKTGFLFKKGERNTAYHRRWCILKGNMLFYFEERESREPIGVIVLEGCTVELCESESEEFAFAIKFECAKARVYKMAAENQAAMESWVKALSRASFDYMRLVVKELERQLEEVQEEARSSQAKSKTKKNQTGLRISSASVQSASITGPCQEGLSNRENGVSWSKPSSVANGLSEGCAWDRDCNVRADGVKPPPIPPRRKTNGGSLESPVSPGTGCFSKLHDWYGKEVAELRVEWLQSQ
The following text describes a protein:
Function:
Probably involved in reactive chlorine species (RCS) stress resistance.
Miscellaneous:
MISCELLANEOUS: The active site is a redox-active disulfide bond.
Sequence:
MNKYQAVIIGFGKAGKTLAVTLAKAGWRVALIEQSNAMYGGTCINIGCIPTKTLVHDAQQHTDFVRAIQRKNEVVNFLRNKNFHNLADMPNIDVIDGQAEFINNHSLRVHRPEGNLEIHGEKIFINTGAQTVVPPIPGITTTPGVYDSTGLLNLKELPGHLGILGGGYIGVEFASMFANFGSKVTILEAASLFLPREDRDIADNIATILRDQGVDIILNAHVERISHHENQVQVHSEHAQLAVDALLIASGRQPATASLHPENAGIAVNERGAIVVDKRLHTTADNIWAMGDVTGGLQFTYISLDDYRIVRDELLGEGKRSTDDRKNVPYSVFMTPPLSRVGMTEEQARESGADIQVVTLPVAAIPRARVMNDTRGVLKAIVDNKTQRMLGASLLCVDSHEMINIVKMVMDAGLPYSILRDQIFTHPSMSESLNDLFSLVK
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Miscellaneous:
MISCELLANEOUS: Present with 2100 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
AAA-cassette D1 is required for interaction with PEX6. ATP-binding in AAA-cassette D2 is required for interaction with PEX6. ATP-binding and hydrolysis in AAA-cassette D2 is required for proper function in PEX5 dislocation.
Sequence:
MTTTKRLKFENLRIQFSNAIVGNFLRLPHSIINVLESTNYAIQEFGIAVHSHNSDIPIVHLGWDGHDSGSSENVVLINPVLATVYDLNQKSPLVDLYIQRYDHTHLATEVYVTPETSDDWEIIDANAMRFQNGEILHQTRIVTPGETLICYLEGIVTKFKIDRVEPSMKSARITDGSLVVVAPKVNKTRLVKAEYGHSNKTILKNGAIQLLKKVILRSTVCKMDFPKDNLFVVYISDGAQLPSQKGYASIVKCSLRQSKKSDSDNKSVGIPSKKIGVFIKCDSQIPENHIALSSHLWDAFFTHPMNGAKIKLEFLQMNQANIISGRNATVNIKYFGKDVPTKSGDQYSKLLGGSLLTNNLILPTEQIIIEIKKGESEQQLCNLNEISNESVQWKVTQMGKEEVKDIIERHLPKHYHVKETGEVSRTSKDEDDFITVNSIKKEMVNYLTSPIIATPAIILDGKQGIGKTRLLKELINEVEKDHHIFVKYADCETLHETSNLDKTQKLIMEWCSFCYWYGPSLIVLDNVEALFGKPQANDGDPSNNGQWDNASKLLNFFINQVTKIFNKDNKRIRVLFSGKQKTQINPLLFDKHFVSETWSLRAPDKHARAKLLEYFFSKNQIMKLNRDLQFSDLSLETEGFSPLDLEIFTEKIFYDLQLERDCDNVVTRELFSKSLSAFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGILLYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRPGRLDKSVICNIPTESERLDILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKSVHRWLSAADQSEVVPGNDNIEYFSINEHGRREENRLRLKTLLQQDVVHETKTSTSAASELTAVVTINDLLEACQETKPSISTSELVKLRGIYDRFQKDRNGEMPNGENSIDIGSRLSLM
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
PTSPEKVKTKLMSVWNNVKYGWTVRTRTSFNKDAPIWLLGVIYHRKMTQFYGASAVVDDGASFDAFLEDFSSRLWFTYRREFPAIPGTDIRTDCGWGCMLRSSQMILAQAFVMHLLGRQWRWQQVHTEAGEVRLPRHALWPLREGFRCTGGDGTAVLVRCSPKPVNDPPRWFGDKADASTPFSLHNLVQRGRESGKKAGDWYGPSSVAYILKDALEDAAHRDQRLAQLCIYVAQDCTIYMDDVTALCSAGSTEGVTHRRLPRTVFARREMFSGGQTQRMCIHSSWLHLFVFFVCFLKYGISFLLQLSAAEEKVIYLDPHYCQEMVDVNSQDFPLDSFHCSWPRKMSFSRIDPSCTIGFYCKTKHDLEDFTKNIRELTVPKQMRHEYPVFLISEGSCSDHTDTEKRPEEIVHVLQDVYSRDGSVHRNSEEYVVL
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Miscellaneous:
MISCELLANEOUS: The porphobilinogen subunits are added to the dipyrromethane group.
Sequence:
MKILIAARGSKLSRVQVDMVGEKLRKIGIEYDVIDIKTKADLFSTEPLSKLGKGVFEKEVNEAVLEGKADVAVHSMKDILSEINPELEIFAVIERDPPYDILIAEKNLHKLDPNTTIGTSSIRRKNFIKYIRPEINTKDIRGNVDTRIRKYLSKEYDGLILAEASIKRLNISISYHRLNVYDFTPEANQGIIVVLGRKKDEKVKEVFKEITHKDTLDEALAERATISVVGGGCHSPIGVLFRKEGKEFYGIASYSDGKKKITVSISKAGDPYTIGSELGLLLKKEMKNEGIIP
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MAVVNTSIPGLSGENPHYIPGYTGHCPLLRFSMGQTYGQVTGQLLRGPPGLAWPPAHRTLLPPIQSPRSPVISKGRLPPRRGHERLSSSIIPGYTGFIPRAQFIFAKNCNQVWAEAMSEFTRRHGEQESHQLPDGAKGEREVEEDQLREAEEPPLKQELAHASPYSMDDTDPHKFFMSGFTGYVPRARFLFGSSFPVLTNQALQEFGQMCSRGRAHKDPKPLSPLPRPTFQNLGLLPHYGGYVPGYKFQFGGTFGHLTHDALGLSITQKQLPA
The following text describes a protein:
Function:
Plays a role in axon and dendrite arborization during cranial nerve development. Also important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage.
Subcellular Localization:
Cytoplasmic vesicle. Cell projection, axon. Cell projection, dendrite. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites.
Sequence:
MAAAQTFSANCDPVNFHNLQSYPSESVTYSCKMGNVSSLMEKQDFPNEGFNLDFRPFPEPSCKRGLHQKEFLSYLNITKKEGKNNKKFPSGLGFRREHSLQAEENDYPVFYHKDHRGTEFSKSSLPERGHSDKSRFGPSALKSNVKAFMSIQSLHQSTNKLSKSNGSLNTLGCVGSPPCRGPLQPSNSHSNNPSESGNDEDDDSLSDSKQNSINSLNSYSPSFTVARGQISASLGHINHIGGSLDRASRGLRDTMAGEKGTLSCRNMATLSRLQCSGEPPPPYEYSESVEDVARQLEKRLQEKGMEAQQLRRNASDNDDPFTQVFEDKRRLWMEELDELKQMYMSKLQQISQQALRSQRALQLQLYKVQQEKKRLQEELNSLQGENEELRQKQSQSDNSGPNLEDSKWEISQKAGEISFLKQQLRDSQAEINLKLGEVVSLKVQLREAKALVKEKEKESAELSDCLQALEDVKSQTPVDLPRDSSDTIDVERLRAELMLERRQNEAQILIFETERKVWKEEKDKVLRYQKEIQSSYLEMYQRNQALERQVLELRQGVGQSLSSPASWMDTVET
The following text describes a protein:
Function:
Required for mRNA nuclear export. Involved in the nuclear pore complex (NPC) distribution and nuclear envelope morphology.
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein.
Sequence:
MELRSFSRQPDGILANPRLGREEVLEGEHPQDARLARQSIWLSPSLIAEYIQLFFNFIIGTIGLSLAIKFILMIRNDVNLKLEHNVREELDKIATCKSRYFENQCEPHMRVPALEVRCNEWSKCMNKEIVSGSDYQWAKAWARTLAEVINAFFEAFSIRSFLFILISIIGIIFVTNTSFGSYRVYLNNKDTKSVRHA
The following text describes a protein:
Function:
Regulates nitric oxide production.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPRHSKHSCSNSGKFSNYERQLLKYGTTTERLGKDSIKNFDSCSLCLNDVIMPVICNKGHLYCKECILTSLIDQKKLIKIKEKEWEQYQNKLKYEQDQKQEKQHQDSIKEFEKNVITLEGIGSNDDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTTTTTTTTTSDVNNKDKEKKEIVEKEIKLNSYWVITPDNKDKAIEKPRSYTVCPADGKHPLKSAQLINVHFTNVKPSSSDSNDSNNQYCCPICSKVLSNSTKTRLLKRCGHVFCSCLDKFKEDSSSQLSCYVCDKPYTEDEIIQIHSGGTGFSGSGSNLEAKKYTHTAIV
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MNDKENFSIVEYFGNDKGHKCGYCQGSNSNLSHGMWAHTMNIQDYENLINCGWRRSGHYCYKPMMKDTCCPQYTIRCNAKDFQMNPSHKKVLKKVRNYLSKETNFNTKPEKSSKTDHNDCASESLTMIRSHEQHHASPPNKSEVPILSKLSKEKPGSPTILKCNPKTIEEFLDENYHNSSQKLKIKLVESTPTGLKDTLVIAYKLYVKYQIHVHHDKEEECTLEQFKRFLVNSPLQKSHSKSGCSTGYGSFHQQYWIDGELVAVGVVDILPSCLSSVYFFYDPDYNFLSLGTYASLREIAFVRQLGQVDPNFVYYYLGFYIHSCPKMFYKGQYKPSFLLCPETYTFLPFAEAVLKLDRNKYSRLLENVDSSEEKKVLSKVGIVYRRQATTFGIYSSLKRLDEDEVKEIEQYAVLVGNKSASRMLLYRS
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Increased expression decreases growth rate, and after 3 days increases the expression of 51 loci encoding 33 protein-coding genes as well as some non-coding RNA.
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core (By similarity).
Sequence:
MTARAAGGSASRANEYADVPEMFRELVGLPAGSPEFQRHRDKIVQRCLPLADHIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGEVRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELGMDRAEVIEGLLAGSSYHTLSIDSGGGSDDDARAITDTLGDVDAGLDQIENREVLRPLLEALPERERTVLVLRFFDSMTQTQIAERVGISQMHVSRLLAKSLARLRDQLE
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Sequence:
MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
The following text describes a protein:
Function:
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.
Subcellular Localization:
Nucleus.
Sequence:
MMTPESKAIQPAAATTKQTAEATATTTMAHTQQKSQLSTLAKTTTTTATNKAAKSVVSNANSSGNNSSKKLALSQSQKTTTTTTPPTTTTTTTAAAAAEATTNADKMQKQQQLKQQLFAACSIKVKSENTLATTANAALAAATTTTTTATPALATGKAAKTILENGIKKESTPPAVESVEASSSSSSSSSSSSSSSSSWPTTRRATSEDASSNGGASADEEKSEEDPTAAVAASSTATTTSDLATTSRPRPVLLTAVNPHIICHLCQGYLINATTIVECLHSFCHSCLINHLRKERFCPRCEMVINNAKPNIKSDTTLQAIVYKLVPGLYERELMRKRAFYKDRPEEAALATPEQRGDDTEHLIFSPSDDMSLSLEYAELGELKTDSEPELVDTLRPRYLQCPAMCRVSHLKKFVYDKFEIDAQRFSIDIMYKVKTIVLLDYYTLMDIAYIYTWKRDAPMRFYYRVYESPQPLVKPAPRRVLPLKLEKQERENQEQQLAVEVASSKVEPVSLPEDQKAEASIKVEEQESTREIVKEVIKDVAATPPTETLKLVINRNMLDKREKSHSPQMSSKSSSKSSPCTPVSSPSEPNIKLKIDLSKQNSVTIIDMSDPERREIVKPLKPEKESRSKKKDKDGSPKSSSSSSSSSSGERKRKSPSPLTVPPLTIRTERIMSPSGVSTLSPRVTSGAFSEDPKSEFLKSFALKPIKVKVESPERTLNNRAITPPSPSVQQSASPKSKGNNLDDSILMKPPSCMPPKSIASSKRKSKEPVKAVSKKQKLSPPLPTVDFKIRLPVTNGNSSGTASPKIEKPLMPPPAKPPMLAPRKLQPSAQFAPPPSPIHHHAGVQMSAPGNRTPIAKRYQPILPKASRPNPFANIPNDVNRLLKDAGTEIKSIGGGSVENNSNAAQKPHLYGPKGESKMGPPALPATTPSQGNKNVGKQAGNLPMSAPPNKGNSSNNYLNLALFNSSKCKGKEAPPGCRTPMYTPNSPIYSPSSPQYVPSYNIPTMPTYKYTPKPTPNSGSGNGGSGSYLQNMLGGGNGGSLGGLFPSPPTKSDQNTNPAQGGGGSSSATQSGGNNGIVNNNIYMPNEDAPEKQQVKVKSLLNSCNINIPSSLSITISRDNGDSSSPNNGQHPKHKSPVNNYIEIVKLPDQPQDQVQAAKEAQKRQSPPAAVPGHLAAKLPPPPPSKAIPSPQHLVSRMTPPQLPKVATPPPPSSPRVITPPKTSPPANAAKVTPLKPVLTPTQVDKKTPSPEKRTAAQMGSHSPTASENKSPKGGPAGVANSTGGAQNGDPAAKKFRPILPRQNGMPELAPKLPTLAPFVGFNPLQNPAAGKKVPPSKKSPNAGAAAHQSGQQKLVNGGQSQPAQQKTSPPAQKNQQQVKKVSKNPTPPPPSLPAVGKMMPHPVMHSQNAPLSIASSASAAAVASGQLDLSNFLKENLRRVHAAQAAQAAQVAAAANQSNMMYNLAQMGHMTPAMYNYQQAYFREQLSRMQRVGNEVFNDYLQKLKTAAATGGGGPVEGELKPMLPTVTLPSPGATPPAASPKTSPLPAGKLTAAATAPQTKGNSSSGAANARQQTAATGNNGATVPAASLPPATKSK