lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Note=Localized to the basal membrane of Sertoli cells.
Sequence:
MERLLAQLCGSSAAWPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACYLGTPRSPDYILPCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVLAGCVAAVAWISHSLALWVLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPPLLPGPMARLCLLILQLAALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGVPASLGGP
The following text describes a protein:
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.
Sequence:
MAGAGSAAVSGAGTPVAGPAGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGVYPPGSPSK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MESDAASSSSGGSPPPRHELRQAVSQHSFYLNTSPLYFKPPRFPPPSYHSVSLTGEPYSAFSPPAFYPMFGSGYTQKEEPQKRKITSPTVDSQEHESSDKEAEEAEDSSKRKTVGLPHMGVTLAPHLMSSTPSKPIPGMIDLSRLQLHHRLPGVNVPVQVKQEPLSPSLAWHPSPLLLRPPYYSALSHNLLPYPYFMPGPFMHLPSAAFYAKEELRSNQVTGERAPRNEMSSTEKLGLSVHVDDSYYVDVGGDQKRWKCRMCEKSYTSKYNLVTHILGHNGIKPHGCHLCGKLFKQLSHLHTHLLTHQGMRPHKCQVCHKAFTQTSHLKRHMMQHSDVKPYSCSVCGRGFAYPSELRAHELKHEKGQENVCVECGLDFPTLAQLKRHLTVHRGPTLYRCTECQKTFQYPSQLQNHMMKHKDIRPYICSECGMEFIQSHHLKQHTLTHKGVKEHKCRICGREFTLLANMKRHVLIHTNIRAYQCHMCFKSFVQKQTLKAHMIVHSDIKPYKCKLCGKEFNRMHNLMGHMHLHSDSKPFKCLYCPSKFTLKGNLTRHMKVKHGVMDRGLDERLFQQRGGLCLSGSMGLLSHFSQEEPFDLSQKPGLRLSQSDGESVPGSSCQEEEDEESLYRRSQYSPEVDQQEPASQEQYVSELEEKQHECPDELRSMQEQEKSEKSLRDEKIEEERKVDVESTGSQVELVPPAELCDPNVDGEKQKQNSKTARVLRCVSISEDSKQDQAEQRKLQAEDVDSDCE
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MASKEKDLEDRLREVGSRLASPPSAVDELLPLLDQTESLLSRVDQSPTQSMSNALRPSMKALVVKELLGHSDIDVKVAVASCVSEITRITAPEAPYEDDLMKEVFQRIVQAFENLDDVSSRSFPKRVSVLETVAKVRSCVVMLDLECDSLITEMFRHFLKTIRPNHSEKIFSSMETIMTLVLEESEDISPELILCLLDSVKSYNKDMLPVARRLGEKVISKCAGKLKPYLVELSESTGMPLNTYGEVVASICQECLDSVEQNDVDDSKQSERTVSDELVQGSDKMEQEVNCPEEVTSTEKSPKSVMSNGTVRMGNGGSTTEPSSPKQEPEPSCPGDQSKRANASNRDMSVNLEPVAGKPDAISDVKPKKTRGKQTTLSDLRNSGDHCSDSIGKEVPGKHDLVSLSGADSGAVKDALPAEAEIPVATRRKRGRPSTKLAATRHDDSAVAAPSASPLQQKVSEMGEKAISSKDSNLQKESDGITGPEDIEESPIGTGDSEEKSRRQQNRKSSTSKTERGDSSQKSGTLKNKQQDNLKAKKDKAGEPILKETVSSLRSAAKSPKDQGILEESAKTKSGRKREHGGREISETPTVNKELDGGLVGSRIRVWWPMDKKFYNGVVDSYDHASKKHKIVYTDGDVEILLMKKERWEFLKDDNKNDMEQAKDSSNSDAASEESKSKRMKTSSSSNPKETNTETPTKSGKPSGSRRKGRPRKAGVLNLDDGPSSSSKANEKATSRSKDEGSKSDVKLKDDSKSTVDKADKSTSKTGSQKKDNVHKFIRNSIGGTPKSASKLMDDTVSAVSKVRKDTSKSKSSEDSPKTGQKLRGTTSPTTGSESEANIDFEKGKAKVRESETLAELPSCATPKAPESEASAGKKRKRRGQT
The following text describes a protein:
Function:
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLKHYIHQCVKASSCKHSLSVKQRYFHCSALNGVASMFRMPALSPTMEEGNITKWHFKEGDSFKSGDILLEVETDKATMDVEVQDNGILAKVLIEKGSNIPVGKNIAIVADAEDNLKDLELPKDEASSEEQSFSSSKEEVKPIVQDRETKSNVEHKSTSQANDAVNKSFLPSVSYLIHQYKIENPWSIPATGPHGRLLKGDVLAHVGKIDKGVPSSLQKFVRNLEVLDFSGVEPKKPSYTEDSVPVRKSTMIETLKTVPMKDEYITFERSISLEKLKSLLAKRKEKDAFGIDEVVSAMIGDALSISELSKVEPNSIESAYDLLLGAPIVKLKSSVSNFQPKLFPKNNNTKDLHKYIRDSMIGLPSNLSDYVKLNFSSVTKSSSNNVEFLDDVYDMLLGSNSDSIDSRINRHEEPSTTEDLTLTLSIKDNISKSRAIKFVDCLKSNFENPEFVLSRW
The following text describes a protein:
Function:
UDP-glycosyltransferase which uses UDP-galactose and malvidin as substrates to catalyze the biosynthesis of malvidin 3-O-galactoside, an anthocyanin conferring purple pigmentation.
Subcellular Localization:
Nucleus.
Sequence:
MAAPTVVLLPVWGAGHLMPMLEAGKRLLTRGGRALSLTVLLMPAPTEEVAAELDGHVRREEASGLDIRFVRLPAVEPPMDSRGIEEFVSRLVQLHAPHVRAAMSSLASPVAAFVIDFFCTTLLDVSRELAVPAYVYFTASAGMLALKLRLPSLHEEVTVQFEEMEGAVDVPGLPPVPPSSLPNPVMDKNHPNYTWFAYHGRRFAEADGIIVNTAAELEQSVLSAIADGRCTPGVRAPTVYPIGPVISFTPPAEEPHECVRWLDTQPVASVVLLCFGSVGFFTAPQAHELAHGLERSGHRFLWVLRGPPAPGERHPSDANLDELLPDGFLERTKGRGLVWPTKAPQKEVLAHAAMGGFVTHGGWNSVLESLWFGVPMAPWPLYAEQHLNAFTLVAYMGVAVAMKVDRKRNNFVEAAELERAVKELMGGGEEGRKAREKAMEMKAAFRNAVEEGGSSYAALRRLSEEIMCKVDTNQ
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPTPSAQLDQGIISSNGGTSGVSASSTRFRHRKISVKQKLRVYKASDLKDLDQDELQQRELQEIETGVEKNEEREVHLHKILQKNQLQLQDLYIPTPDASRVWKEFDEMYQGRFTTPASYIQFSVQLEDCCGPAYNMDERDEAYLAELNGGESEALTEDEFELLMTNFESAIRERQPFLAMDPESLLMYEDLKPTMLKNDIGDAGLKTELAAELQLGDQPFVTKFDSPATLRTRNMVELIEKYGAEVYEYWKKRKVEVAGGSIIPSLKAERSTDKDDNDPYFCFRRREVRQTRKTRRVDTQNSQKLRLLYQQLQYTKELALLVAKREKMSMDMLLRDREIFQLRCDIKTVKRGLGIKGEDELLISQKRRKLVSNVITNKKYVSTQADAAALRRLRVAKVKDKKLLSKQLSSTDLKRQQSQLQKLDQQQRQQQQQQQPQINGAQCQQDGSGVSHVYVKLPTSKIPDIVLEDVDKVLSMKERNTKRFVEEKMKKRREEDGDIFFNLTDDPYNPVFEITIPQNISPTNAPFSSIVSSNFEISRSYYTPNLQNCITGNTNSVLAYNKEGEIVESQKYKKIEFYSPFEEKNDSHTREIPVRFRRRLGRYGVEYIDRKDVSRNPSDLLGEFMDFSLIAEQEQSSDAVNVYDSQLDELFRLHDKWKYDSDHNAYGIKFSDEPSRLNQISNETQVIRFGTMLGTKSYEQLREATLKYRQNVMAQRKKLVNAQRQQQQQQQEQQEQEHQQA
The following text describes a protein:
Function:
Probable scaffold protein that may be involved in mRNA transport.
Sequence:
MTAENATLLEPVLGKDEIGWMFVQEYYTYLNKEPNRLHCFYTKKSTLIHGDEGESISLCHGQQEIHNKILDLDFQNCKVLISNVDSLASSNGGIVIQVLGEMSNKGKLSRKFAQTFFLAEQPNGYFVLNDIFRFLREDVEEEEESPDAVEKEKKDVASEPYVNGVQSQEHLPSAKEEGHYQDPAATENNFATAALISNETDSLNQATLAVPEEPVIQVTEASVPSFVSQQENQLQDEALTSNSKNADAIGASDANVATAPKSWADLIARNHPDVKSQASVSSTASTTGQTVKGVNADQTQQPTAPYTQSNELLETSVFVKNIPPETSDVSLKSAMSIFGPVKAIEFARRKGTAYVDFVNHECVQLALNKKTLQINNATLNIEERRRLFSGKFNKSGDKKSNDNYNGMKRNFRKGNRGAFDGRSKEVTTSKKQNN
The following text describes a protein:
Function:
Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDKKATASSGKRILNINVGVLGHVDSGKTSLVAALSTRLSTAALDKHPQSKERGITLDLGFSAFTVPLPPHLASLPYDELQFTLVDCPGHASLIRTIIGGVQIIDMMILVIDVTKGLQTQTAECLVVGEVATSRMVVALNKVDQLQPEEERPKLVRRAMKRLGTTFAMTKFTGVTMIPVSAKPGGQADAPPLGVDDLRAALVALVPPAPRPPPAPGCFLFAIDHCFPIKGQGSVLTGTVLQGTVGVNDVIELPALKQTRPVKSMQMFKQPVQRANAGDRVGVCVTQLDAGLIERGLACSPGTVPTFRGAVAAVEKIRFYAGRVPSRAKFHVSVGHSTVMAEMTFFGLPDGEGVPRDTALAAMIANLNAMALSTTPMAFDAARDYLYQEELYGLEGRPIADPSVAAAAAAAEGGEGEGGKEGGAEAAEAHDGDDGLDRHFGPQWVLLKFDQPITAPKDALVIGAKFDADIHGEACRLAFYGRLVRLVDPGRPQELAALQVYKPKLRSGVIERVQPDGVTAIVRSLIKKESSIDVFVGLKVKTGRGEQGVIEGSFGKSGKLKVNFPGGLAPEGRSAADNAITLRCKRYVFDPNAKKVLRQ
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRGKIEVKRIENKTSRQVTFSKRRAGLLKKTHELSVLCDAQIGLIIFSTKGKLFEYSSQPHSMSEIISRYLQTTGASIPVQDNRVELYDEITKMKRDTLNLQLSLQKYKGDDLSSAQYEELNELEKQLEFAVNKVRARKHELMLQQMENLRRTEKMLEKDNQEMYQWLMSNQMYKQQSAGMEHNDDDQNEEAITELNLMGEQPLLSQFSFFGEEQVQPSSSNVLQLAAASTSTSAYRLQSSHPNLQDSDLPGCNYAHLKD
The following text describes a protein:
Function:
Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MDPVTCVAHEILLNHHGPTGMDLWQLLLTLAVAGSSDAFSGSEAIPATLGRASQSLQRVNPGLRTNSSGKPKFTKCRSPELETFSCHWTDGVRHGLKSPGSVQLFYIRRSTQEWTQEWKECPDYVSAGENSCYFNSSYTSIWIPYCIKLTSNGGTVDQKCFSVEEIVQPDPPIGLNWTLLNISLTGIHADIQVRWEPPPNADVQKGWIVLEYELQYKEVNETQWKMMDPVLSTSVPVYSLRLDKEYEVRVRSRQRNSEKYGEFSEVLYVTLPQMSPLACEEDFQFPWFLIIILGIFGLTVILLLFIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAVHDNYKPEFYNDDSWVEFIELDIDDPDEKTEGSDTDRLLSNDHQKSLNILGAKDDDSGRTSCYEPDILETDFNASDMSDGTSEVAQPQRLKGEADLLCLDQKNQKDSSSSNATPATQQPSVILAEENKPRPLLIGGTESTHQAAHTQLSNPSSLANIDFYAQVSDITPAGSVVLSPGQKNKTGISQCDMHPEVVSLCQANFIMDNAYFCEADAKKCIPVAPHVEVESRVEPSFNQEDIYITTESLTTTAGRSGTAERASSSEMPVPDYTSIHIVQSPQGLVLNATALPLPDKEFLSSCGYVSTDQLNKIMP
The following text describes a protein:
Function:
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MRNIAVILAGGSGQRLGENIPKQFLKIAGKKVIEHTITVFQNHSLIDEIVVVVHPDYIRDVEDISLRNSFNKLKKILLGGKERYHSSLAAINAYDEEVNLLFHDSVRPLVNERIINDCIRALLTYNAVDVAIPTTDTIIQVDDNNEIVKIPSRILLRNGQTPQAFKRSVIKAAYEKALLDPLFKTTDDCGVVLKYLPDESIYVVNGEQFNMKLTYKEDIFLLDKLFQLRSIRNQPTLLEKSEMEELQGKVVVVFGGTYGIGQDICEICREYKTSLYVYSRSTGVDVSNSQSVRRVLSEIFDKEGRIDWIVNTAGILDKQPLANMSYEAVHQSIDVNYLGNIIVAKESFFYLKESKGSLLFFTSSSYTRGRALYSLYSSSKAAIVNFVQALSEEWFEYGIRVNCINPERTKTPMRIQNFGNEPEDTLLEPKVVAIVSVNTLLSEMTGEVVDVKR
The following text describes a protein:
Function:
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton.
Miscellaneous:
MISCELLANEOUS: Present with 48000 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MTGPIVYVQNADGIFFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADERFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPDRRPVYIQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGIQFVNWPKLVDVGFLVVHQTHDKEQQFKGLKYAQSPKFSKPDPLKRD
The following text describes a protein:
Function:
Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MPTLNHSWKENVYFVLVEPKESGNIGASARAIKNMGFTNLTLINPVPLQDEAYWMAWASKDVLEKAQIFRELDESLKDKALIIGTTRRRGAKRGAIIDVKDGVKRVYEVAQNNKVAILFGREDKGLFNEEVEKCGYLITIPTSLLQPSLNLAQAVLIVAYELMRCEELKDFHMNRQFYVSQTELDKLYERLFKLLKKIDYIPDNPDIEKRIINNFRHFFGRTGLTFWELKLLHGLCTHIEELIAKCQTNPKA
The following text describes a protein:
Function:
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis.
Subcellular Localization:
Nucleus.
Sequence:
MPKGGCSRTPQQEERSLSSDMVEKQPGKKDKDKVSLTKTPKLDRSDGGKEVRERAPKRKLPFTVGANGEQKDSDTEKQGPERKRIRKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDMTPKHPSQSTVCQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVASSPTMVNLLLGKGTYTSSEESSAESSEEEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKTVTPVKDEYEFDEDDEQDRTPPVDDKHLLKKDYRREAKSNSFISIPKMEVKSYTKNSTIAPKKASHRILSDTSDEEDVGVAVGAGEKLRLSAHTMLPGNKTREPSNCKQQKERNKVKKKRKKEIKGKEVRFGKRGDTFCSSESESESSESGEDGGDSAGSPGCLKESPLVLKDPALFSSLSASSTSSHGSSTAQKHNTGHADPHAKHWRTDNWKTISSPAWSEVSSLSDSTRTRLSSESDGSSEGSSVESLKPVRKRQEHKKRAGLQGTLPDRKNSFHPSGDGAIPKLDKEGKVVKKHKTKHKHKSKEKGLCSVSQELKLKSFTYEYEDSKQRADKAILLDDVPAENKLKGLKHERDHCKKEEKLSKMKSEEKDWLFKDEMIKVSREEKSLKRIRDLNKDGGRAFREEKDRSNKAEKERLLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDFKEEKIPKEKEKIFKEDKEKLRKEKGYREDSAFDEYCNKSQFLENEDTKFSLSDDQQDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVARLILETVKEDSKEKRRESKAREKRGDRDIFSRKKDRDSLERRREHVADRHRVVPSFLCEKDKRRRESTEGSRDRKEAPEAAKERRDGRVKPEEAHREDLKEYGCDFGKSLEPWERHHPGREKKEKLKLEKHKEKSSDKDKSEKLILEKCQRDREFDKCFKEKKDAKEKHKDVHSKDKERKASLDQGRDKREKAFPGVLSEDFSEKKDEKKGKEKSWYIADIFTDESEDEKDDYTASGFKIGEASEGRGDGPPEREDGRELHPPDRHRKHSADRQAHAEKQKDKEMREKKKEKGAVDGGKDRREKTFEKHKEKKDRKDRTSVDSVQDKRSKQKPPEKGEKRPPAEDKAKTRHRERPDREQGRERKASKGAEVEKSLLERLEEEALQDFREDSNDKASEASSDGFPDRGQDPSLSALLDVSFPEPPEERVRERERHRHASSSSKKSHDRERGKKDKLEKKDKSDDYKDAGSRKDASQYEKELLDSDAYGASYGSKADAEDELDKALELFSTEKKEKNDPEREPPKKVEKELRPYGSSALSLLKEKRRREKHRERWREDKERHRHHREEPKPPARDTAPGAFRDKAKDEGGKLGEARLKEKIKENPEKEKGDPTKLSNGNDKLLPTRDPGKKDVRPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMRQMEKLRHRSGDPKLKEKARPAEDARKKSLDGPPKKPPGPDLTPKDRKPKESAPPAPATENKPHPGLAVDPRDWLAGPHMKEVLPASPRPDHGRPTGVPTPASVVSCPSYEEAMHTPRTPSCSADDYPDLMFDCTDPQPMSSTSASACSPSFFDRFSVATSGISETPGQTPTRPLCTNLYRSVSVDVRRTPEEEFGLGDKLFRQQSVPAAPSYGSPGQHPEDKAPGPPAPAEKFTCLSPGYYSPDYGMPSPKVDALHCPPAATVNLTPSPEGAFAGLQAKSPPSHRDELLAPSMEGALPPDLGIPLDATEDQQATAAIIPPEPSFLEPLDEGPFSTVITEEPVEWAHPAAAEQGLPPGLIGGAPGDTAGWPVGSDLLLKSPQRFPESPKHFCPAESLHPEPPYPGSPVSYPLPVPEPGLEAKDKAEGAVPAAVSASEESAPFAPPSRLESFFSNCKSLPDAPPDAPPEPACVTAVAQVEALGPLENNFLEGGHNLSALGQVEPVPWPGAFPAAEDDLDLGPFSLPELPLQTKDVPDVEAEPVEESPLVPPENTPLGAPVLPGGGEAAGTAADQQLVSPSDQAAARLPTEAAPEPLEEPKPAALPEATAETGSGPDGRAPEDSHPGSGLTPALSEQRPPGSGDEEAEGQDLSASPHSTPDAPVDGSAQTHVADGAGPQDSAGLEGPLDSVQPESTEPEPKVTAEAPKAPKVEEIPQRMTRTRAQMLANQHKQSSPPTEKEPTPTPTPRAKGRGSEDDDPQAQHPRKRRFQRSSQQLAQQMHTSTRQTREVIQQTLAAIVDAIKLDAIEPYHSDRSNPYFEYLQIRKKIEEKRKILCYISPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFKQQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRDRFNARQFISWLQDVDDKYDRMKVCGEQLLSPAGGQTSVGPHLDPPQRSQHPPAALPWMC
The following text describes a protein:
Function:
Involved in heme degradation. Catalyzes the degradation of heme to biliverdin, with the release of iron. Forms biliverdin delta (70%) and beta (30%). Under anaerobic conditions ferredoxin--NADP(+) reductase (fpr) can provide the necessary electrons; Bfd is not required.
Sequence:
MDTLAPESTRQNLRSQRLNLLTNEPHQRLESLVKSKEPFASRDNFARFVAAQYLFQHDLEPLYRNEALARLFPGLASRARDDAARADLADLGHPVPEGDQSVREADLSLAEALGWLFVSEGSKLGAAFLFKKAAALELDENFGARHLAEPEGGRAQGWKSFVAILDGIELNEEEERLAAKGASDAFNRFGDLLERTFA
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular Localization:
Nucleus.
Sequence:
MEHSDGDLGAVVRAGTCSSLSSVTGSGSGGGGGGGGGAQSQLLNMVEMESHRQNMNKRKAVDSGFPSGSSSPSSVLQCNSPLLLSDLSKSLTGVSTTATTTGADVEGSLHEVCQLGYNFNGSAASSYYSSLESANTAIDSPRNPFYAQNDRISEALSRNLQQRDQQQQQQQQQQQQHQQCLKKTNMISELLSSSSMNMNLNRSRLRPGPVSQSLDSGRLSQDMIKEDFFQGGSSSSFNHRSSQCAADSSSEQLSSSHHSSPAREDHMATLGPVKKIEAACNTKLEDSLDYGSPGSLASSKGPKRRKNQQKRIVCVPVAASGRPTSEGLPSDLWAWRKYGQKPIKGSPFPRGYYRCSSSKGCSARKQVERSRTEPSMLIITYTAEHNHPWPSHRNALAGSSRMSSLDKGTLAQETANLKAEAGDAGEAGVSVAESPVNSMDHDTDTGVMDEPEPELELPEAHQAPGSPSTTTLELDGGEAQGADSSEPFTSMLSSHQHQHQHQRGDFEVAHHHQGNLHLTGRSGMSMQDDDFFSELGELPESLLMFGGRTGVMEDRSDDECGNLGMDNVDPYNLFCWSSGSHLESSSNVVM
The following text describes a protein:
Function:
May act as a component of the auxin efflux carrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIGWQDVYKVVAAMAPLYFALILGYGSVKWWKIFSTQQCDAINKLVCYFTLPLFTFDFTSHIDPFHLNFPFIAADAIGKLIIVLVLAFWAKCTTKGSYCWSITSFSLSTLTNALVIGVPLAKVMYGQMAVDLVGSVVQAIVWLTILLFVLELRRTGLDLVAAEASSGVVSEEKTVEVGGEGEKDLEGEGMEVEEMRRSSKSHRPSLKPLMKKVWVKMAGNPNSYACTIGFAWAFVAKRWHVEMPSIMEGSILIMSKAGIGTAMFNMGIFMALQEKLIACGPTLTIVGMVLKFIAGPAAMAIGSIAMGLHGDVLRVAIIQAAVPQSITSFIYAKEYGLHADVLSTAVIFGAIVSLPVLVAYYAALEFIVH
The following text describes a protein:
Function:
This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transporting tripeptides. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKISQADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLLMLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNLGWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRTARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDSAFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY
The following text describes a protein:
Function:
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of a methylated derivative of known natural products orthosporin and diaporthin. Seems not to be involved in the biosynthesis of the identified final product of the pathway and its function has still to be determined.
Sequence:
MVCVPSSSSVMELANLISQSIPKLQDESPQRANDARGNVIEACSKMLALVTSPAEMLKEMVLINLASLQVINHYQIASVVPLNGHIPISELANKCGLPVDILRRILRQAMTYGAFSEPEPDCIAQTDVSREIPRLSPLLTYQLDVCLPSMVRLLDWLKDVDGEHACAYQIAHDTKDTWWSYASKRPELIENYGKYMALITSGGAHDVSYVLKGFAWEKLGNAVVVDVGGADGFVGISLAKEYPNLAVIVEDNLGLKDSADDNIPQHLKSRVVFLPHSFFKPQSALSRDADVFLLRHILHDWNDNDCRAILQALAASMKPGASILVAEQILQRPGAASWQRERVMRALDMQMMIQFGSKERAYEDWDALFKSVDPPLEIVDCVQPVGSADSFMELKRRA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Subcellular Localization:
Cytoplasm.
Sequence:
MPYNPLYESLSNQFDPSRIETVLDPMGYTIKRRALPVSLTIAGSDCSGGAGIQADLKTMTSLGVYGMSAITCLVAENAGGVDSVEEMSPAFVESQIDCCIRDIPCHVVKTGMLGSPEIVKAVARSAKKFNFSKLVVDPVMVATSGDSLVTKDIVSVLNEELLPLTYLVTPNIPEAIVLAKNQGLDISNINSVSDMERCAAVIHKLGPKHVLLKGGHMPVNNLGLKSSDDEDLRVVDILYDGNRFYHFSSSYLKKGEVHGTGCTLSSAIASFLAWEHSLTEAVQFGIDYVHGAITHSPPINNCSTNILNHMTRLRIVPFAPGHFIEYILSHPQVVPAWKEYINHKFTNMLAKGTLPLPAFQDYLKQDYLYLVNFARAYSLKGYKENTFPNILEAAQSVIHVIEEKELHVSMCSSYGVSLQDLKSCEESPACTAYSRYILDTGAAQDVAALDFVQAPCLIGYYVIAARLMKEPFRNPQGPYQKWVDNYFCEDYLSAVRRGCRQIEEIVLKLSPERIQELIEIFIRATKFETLFWETPYYEYVTKQNLEDKEFS
The following text describes a protein:
Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Essential arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3.
Sequence:
MSIFIQKLNPMTGVNDWIVQQEDYDYHQEVARSSFADMLHDTERNKKYETALKSAIEVMHSRGKKANVLDIGTGTGLLSMMAVRHGADSVTACEAFKPMSECAFKVIKRNGFENKIKIIPKRSTDITVGPGGDLGAPCNILVTEVFDTELIGEGALSTFSHAHKVLLEKDCIVVPQSATVYAQVVESPFIQSWNRVKDVYDNEGKLLIKTPSSVRNCAGSAAVHDLQLSQIKPNCLKFLTQPIPVFRFDWSGNTPFIFDQSTIHSIKAAQSGVAQVVFMWWDLQMDTEGKIVLSCAPHWGPPQEAVPWRDHWMQAIYYLPNEVVVSKDAELHLVSCHDEFSLWFNVRLDLRLSEVDYVKPICECGLHMTFSRTRIGQINDASRNKKYISLLEKCIDRDSVILILSDGFYLSLCASKMGAKKIYYVETNYLSRKILIDFVEFNEITNVEVFENIESLVNNGNPEKINMVVGEPYFLNSILPWDNLLFIYLLKGVRNILTNDARLFPKIAVIKGIAVKFSDLNKIRLPLGECEGFVMKDFDELIETSSNISDDNVEAQPLWEYPGIALSKPVDIITIDSNSVPEKVVELSGVFEIDSRHGSCNGIALWIEWLHEEGAKSVISSGPVIPPQVGQQIEWDVHTRQGVCLFADRATSHISYRFKFDFNEGNITFKWE
The following text describes a protein:
Function:
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Sequence:
MAAHMCLQVFAGCYERTTFGYDLLENESEDGCQYSFKGRFTNNAHTGCIKSLAASSRHLASGSTDELVNLYDLEKNVELGSLLQHDGSVTSLSYHDDGHMVSGGEDGVICIWGTKNWECMKILKGHKDAVNSVAVHPSGKIALSVSKDKTLRTWNLLKGRAAYTTNIKKVSDIVLWSPDGQLYAVITNDLVEIYDITTATVCCSYKSNVKILSACFLTDRVLVTAGEGEMISLLKVNDKKTKLSQLTEFKAHEKRIKSLKCVNARGSKSKQTEKWLLSASSDGFLKIWCIDTEKITDSPVLLSEVDSKARLTCLAVRQAPSVVSEEKETSQQTTKRSTESKTDDTVVKKKKKKSKP