lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the racemization of L-alanine to D-alanine, and of L-glutamate to D-glutamate. The activity is low, but likely physiological since T.maritima lacks canonical alr and murI genes, while D-alanine and D-glutamate are essential components of peptidoglycan. Also displays a more efficient cystathionine beta-lyase (CBL) activity, cleaving cystathionine to homocysteine and pyruvate; however, this reaction seems not to be physiologically relevant since T.maritima possesses an O-acetyl-homoserine thiolase (MetY) that bypasses the need of CBL for methionine biosynthesis. Is not able to produce cystathionine, using either O-acetylhomoserine or O-succinylhomoserine, plus L-cysteine as substrates, and thus does not possess cystathionine gamma-synthase (CGS) activity.
Sequence:
MNTDDILFSYGEEDIPLKALSFPIFETTNFYFDSFDEMSKALRNGDYEFVYKRGSNPTTRLVEKKLAALEECEDARLVASGMSAISLSILHFLSSGDHVVCVDEAYSWAKKFFNYLSKKFDIEVSYVPPDAERIVEAITKKTKLIYLESPTSMRMKVIDIRKVTEAAGELKIKTVIDNTWASPIFQKPKLLGVDVVVHSATKYISGHGDVMAGVIAGDVEDMKNIFVDEYKNIGPVLSPIEAWLILRGLRTLELRMKKHYENALVVSDFLMDHPKVLEVNYPMNPRSPQYELASSQMSGGSGLMSFRLKTDSAEKVKEFVESLRVFRMAVSWGSHENLVVPRVAYGDCPKKDVNLIRIHVGLGDPEKLVEDLDQALKKI
The following text describes a protein:
Function:
Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTQSSAGPQSQPSRDFFASSPSATPGSPSKQASQASKQPDALVTPSSVTANTSVCADNLLDHHQHEPQHDAASVVIGIEGSINDSAAIHRRRQQPRRAAVQNAKPLFLAEDEDDAINWPVADQEEGDDFFSTQLADQKVKRPARATVNSDEKDFQPSTLSSLSSPPSETVYKRSPPSDDVQASNGPAKRPKKSWSTPASVATTKSAPRHCSPTPDPRLRHDAFDRRYIGTFVLSAWSLSKGSSYVKPGDAVRIFRPRKKHATAEPKIASKLTNGGMQKAKQTTLNFRGASAGPTNFFTSKQKSKEKEHFIVRFSNMRGFEVGRLPLEVAIWMSKLIDAGIAEFEGVVVDCPPSLTVGCDIILQVKAYIKFDAFFSTLLGSREFDDQNEALRPETAESDLEKTLRERKISLLRMFRVCDLKPRLSNAILKSHKASDDFSSEAMLDQYGGDIQGAVKHAGSDLAISTENGTQLPHAGEDASSTAIDLDVEGDTDAVAHLEIADQLQSAKRQTDGDADTEENDGTELNLNQLDQVYRKAQANDAHLPEVEPPESFVLTLRPYQKQALGWMKNMEMAPGQSSSSQEQSVTQQGNGDTGERNVSLHPLWEEYEFPLDYDNPQANERLILSATRLFYFNPYTGDLSLDFQRASKGSRGGILADEMGLGKTIMVASLLHANRTSDPGEESEGEINAVDAAEGDVSTKRKGSAKQTSLASAFAASTSSVDQRKALLKASVSKGKASLVVAPMSLIGQWRDELIRASAPGSLTPVLYYADTKGDLLAQLESGKVDVVITSYGTLVTEYRRFLDGGGASNRHLSVSAPLYCIDWLRVILDEAHNIKNRSTMNARACCDLVSRRRWALTGTPIINRLTDLFSLLKFLRVEPWGDFSFFNSFVCKPFQAKSTKALDVVQVILESVLLRREKKMKDKDGKPIVELPPKTIVVKELEFSELERRIYDNVYRRAYLQFASLKANGTVTRNLSVIFSVLMRLRQAVCHPSLVLKAGSKVQSGGIRKDHVDRNGEVGVGEGDHVEVDADAVEFGLDSDHVGGNGTPSTQDLRELVAQFQLDEAGEAGDDSTESYTKATVERLIGEMHGDQATVPPVVSDGENECPICLEESQISPCYLPRCMHSACKACLVDYLGQCKQKGDQGACPTCRKGPVQETDLIEAIRTRPATRAASGGASPTDRPGKACTLTSVPSVIYVRNNLRTSTKLSALISHLNTLRATEAAFKGVIFSQFTSFLDLIEPVLTRYRFHFLRLDGSTPQKVRDKLVLEFQSPSPTNHVVLFLISLKAGGVGLNLTAANKIWLLDFWWNSSIENQAIDRIHRFGQTSPVSVFRYIIKDSIEDRILLIQKRKDMLIKHALNTDNHPHGTKPNSEMLANLDLLFGE
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNEKMDTSPPSYDSHFTLETSMHRQLKDKRIILASGSPRRKQLFEQMGFPNVETCVSGFPEDLNKSMYITPWEYAADTSVQKAIAVYEKLAAEEDSPDIVVSADTILILDSEIMEKPNDPKHHLAMLKKLRNSKTPHKVFTAVSVIVPMEVPIHPGYVMKTHLEETQVKFDPSITDEFLEAYVRCGEGSDKAGGYAIQGHGALLIESIIGDFSNVVGLPIRATFKLMEEALEQGDADNYD
The following text describes a protein:
Function:
High-affinity copper transporter of plasma membrane that mediates copper uptake under low copper conditions. Copper transport through the high affinity system requiring CTRl supplies the iron transport multicopper ferroxidase FET3 with copper, which in turn is required for ferrous iron uptake. The energy for translocation is unlikely to be directly derived from ATP hydrolysis and the exact mechanism driving the transmembrane transport of copper has still to be determined. Binds 4 copper ions via its C-terminal cystein-rich domain and is able to deliver Cu(I) directly to both the chaperone ATX1 and to an N-terminal domain of the CCC2 protein. Also able to mediate the uptake of the anticancer drug cisplatin.
Miscellaneous:
MISCELLANEOUS: CTR1 undergoes MAC1-dependent degradation at the membrane in cells exposed to high copper levels and in a fashion independent of endocytosis; MISCELLANEOUS: Present with 1180 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Within the N-terminal cytosolic region appear three 19 amino acid repeated elements containing the M-X-X-M copper-binding motifs; The REP-III motif within the C-terminal cytosolic part resembles a shortened MAC1 copper ion-sensing motif (REP) and plays a role in the CTR1 degradation.
Sequence:
MEGMNMGSSMNMDAMSSASKTVASSMASMSMDAMSSASKTILSSMSSMSMEAMSSASKTLASTMSSMASMSMGSSSMSGMSMSMSSTPTSSASAQTTSDSSMSGMSGMSSSDNSSSSGMDMDMSMGMNYYLTPTYKNYPVLFHHLHANNSGKAFGIFLLFVVAAFVYKLLLFVSWCLEVHWFKKWDKQNKYSTLPSANSKDEGKHYDTENNFEIQGLPKLPNLLSDIFVPSLMDLFHDIIRAFLVFTSTMIIYMLMLATMSFVLTYVFAVITGLALSEVFFNRCKIAMLKRWDIQREIQKAKSCPGFGNCQCGRHPEPSPDPIAVADTTSGSDQSTRLEKNNESKVAISENNQKKTPTQEEGCNCATDSGKNQANIERDILENSKLQEQSGNMDQNLLPAEKFTHN
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSIGGRAQFMSTISLKSCYMKINSLIELFRCGEMPIFSVSTNSEAVVLQQVRVIVTAAELGEKDISPLDVHSYNNTSTDKLPEDQRPRTREVIFFYIYNNDRLHKTQGPYAQRIVWALKLKGIEYETMFEDLANKSRLLLEYNPVHKKVPVWLHDGAPICESLLILEYADDKWNTTARLLPDGPLARATTRFWAKFCDDQIVGRKLYPREKAFNFW
The following text describes a protein:
Function:
May be involved in protein traffic between late Golgi and early endosomes (By similarity). Essential for cell patterning during gastrulation.
Sequence:
MASASGGDVPAGREKDSKYRAYAKAIDQALKTFETPNEWADLISALGKLAKVFQSNAKFCAIPNRVTVAKRLSQCLHPALPMGVHLKALETYRQIFEILGPNKLPECLYLFAVGLFPLMDHCGIKVKSELFTIFENYLVPLGANLRPALPGFLGGVLLALEEGTEFYERSFILLDRVCEKVGPRAFYACLWQAILGSPPVRLPAMIYVNAKFDKLKSLDDQIHLVGDHVNHMVAALCAVADDTGSPLVQRYLLDFLVAAFPLDSTNLTNEDFVQLLRRCLFVVLRRDMSLNRRLYTWLINRSGETKGVSGLSLGGPDDGIELTFFKERVLGLVHGALGEYLALDTIETPFANHQNSMWGDRKEAEQVQFAEVRVCRLLLYLQDRADIGRTILETVFADFLKKSAEFHSSSNSSSLKKSPRKIQQSLKNPRKPGDREGLYLDLNSVCSTSNKDDDVTSVTSSAAANASSAPPPDEEDLVQARRIDELSKTFNMLLNSLEPGFLWTFLGDWYRRIVENNEFERQIHDFSQVVSVCLEMCNVESDPTIRTQHLPRLLETVLEGVSNKNLLSSCDQSDLLQLYTVCQKLLEISTAHPPSPIEVDEIAEDSLSMSQEVTAIEHERSQTDACLSQCLSALSAIFEIYTTRREASLIPLIDASTTLLNAFLEVPIYYLGFGIVDNPGDYCRESSEEVQPWLKNMLKVIDGPGWLREMRAGLCADVSARASLLELLCKIYVKSVQVLEQHEEAAHRPHDDFYDEMTHVLLKPLLAKRDCQFIEQGKVFGTCGEAVWLGIGSRKFCTEQQRLARLLVELHSRRPLEASSDVESIVVQSLTSTDDLVCSEAARTFHRIWVLARNLEDREQQGIPYQKPFNRAVMILLGVLADESVAKTRTELKAAAAEWFHDCSKHQDLPRIVQMLSTMLMNPVTARISIQYIRQETKMTTDTCPVIPADISAVTLVTIDGKQRLYHVTGQPAIDSSSTESTWITEVRNRLLRTSTGEDSGDPSAAGAAGILRSSSPDPDVVPAFDDDTDSLDTLSMSDSIDETVIHVLREIVDQVCEEFNEEDLERERIMTMFAMDNVEPTGASFNLPHDSEADDEVAERPAPICPDSLVQRVKKGHRRQDSLQESIFNMTDKDLSAFDTSEIFRPSTESVSRGTGAGAAAAAAAAGASSKDTILPGTVSSASSTSSAAGGTSSLFEEMHTHMLLYGESGKVVDLARAETAFRILTALLAPRGATGNRMLLNCLVSSGTTTTSDSSAEHSLVELMNRHVRAILGQHFWSAPASDEEKHKHITLLELLITISLHFLRSYFLNSPISPVTEADLTSLWKCKISALEFLCELFRELSAMLNEHESKQFVQFVQTILNRSKLQKCILHLLLTAVDHNPMESSSSKKTGGGGGPLSVSISKFNEGLLGESRRLSPLLAAYHRSLLTFTSHAIRLECDIKRGFATFSDANSSHRFSIIQSVMNQSFNNRTSRVDNHASTVELRAFLLILLNALKKQPHRHEMWLQFVVQILPWVERSLATIVCRVVEQLCKNMENAMSVAYENPPTSDVVVDSPGDVRDEPDCYPANYLAMTMELLTTLVHFCVIDSVPTSAVAGGAPGVGGAGGVTSSSGGVQQVIHENATPTPSSTSMVGHAMSVIPGSKVATELFSQLGKVFSMSGDSGGVISKLDSSRQHGNGWRQAQSDMLSSLPHSLATICNVWTVVRRAQPPIVPIGTNSQLRRLVLHLLSPIAQYHKHAFLTSLALVWLTRSTAKPTVTLRKQDPDRATFEYSSAQLDITNLLLSLQVIPFEDLISSVNSTLREASFKANKVGITTIDKANFPTEEPLLELVHSCVSAVLQTQLRLCWSSLLSLFSEAPLSALSARAVFLLFVILSDFVKCVGGAYIVEDKAMYRNVQEVCSRLAEAVNAIVGWQLETTTWLKRTLVVKQDHGSSISSSIRSVDQSPIIEIQSSMSNVSGGGGSLDNPSGSTRNSTLSLINKPGGSIGTGSSVTSTLVDSKSENMKIEKKSSSNLRASIKDTNNNRRDPAHSTQALFLLAERLTDLLDSVSKSDEKDKVLPTLQAVWANVVPYLKAKNARNARFFLASSQLLASMSSYSYMRPVWKKTTLDLLLDSGFFKMDHSALKQWLVVTDHLMTHDRTSFKDLLKSISYSPNTSFSIMTSKEQEYEARAQALKRLTFVVFGSQLDQYHGQMNDIQERLSDNLRVSQSPVIRSAVFLCIRVLLLRLRPHSLIGVWPIMVTELVHALSQLEQQLQSGEQDSGATAASSDQWMQLYVAACKLLETLCTLPAGYLSHFQMFHWAFVSSVSADKTEIFKPFAERINDLLAKKYGELLTPETMSNHTASLGAVKILTSFEELRPFFYTLANLNKSVPESNNTLRDAHALSGSLTYKNAVARLESALYVDFSEHLQF
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVLELLSNRHLFRNEFLHSAHRLLRVCQVFGTVPWEVTLFAHVTQPLSSWRERLFRTLNALYSLALGLAVLSATVLQHAEFDHHMPFVTHMLYISEYSMENGVVMMVLIGCHYQRDCYRHYGEQLLAVAVDLSLCGGTVDFPRIETIFNRVLACIALFFAGVLTVDLLYNDLVVWRFARSSAVYTLSNVINVLALLQYAYVLYVLYFCYYDTNRLLASYNRHLLVRGTDDTRYERRRGAHEIVLPAGALYDYAHLIDLLRRTHLRLAQLLEQANGCFGVLIVFTTTASFVVLSLQFFEIYRATTVRPWTVTDTYLLVYTVLWIVLHAAKVLMILYPAHLVQRERDRTGPILCHFNPAALDSALNSALAKFSSQLLHVQGPQTACGVINLEMTLISTMVGALTTYLVILIQFDTAITQGQTADSNGPSSSPSLPNDTNTPGNGTTI
The following text describes a protein:
Function:
Copper chaperone for superoxide dismutase 1 (SOD1). Binds copper ions and delivers them specifically to SOD1.
Subcellular Localization:
Cytoplasm.
Sequence:
MTNTFEIVFAVPMECDSCVDSIASVLKGLDGVEKFNINLKDNLVSTEGSLPPSEISKAIQSTGKDAIIRGTGKPDSAAVCILESFDPNDIQHPVKGLARLVEVSPNDLFVDLTVNGLPKGVYYPSIRVSGNLSQGALSTGPSFYELNPIEVKTPVNAETTISSRGAKLEEDSTLYAGQAFLHAKLNINQLIGRSIILSKIKDQVAPDSLCGVIARSAGVWENDKQVCSCSGKTVWQERIDARVKGVHV
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIWNNRLILALSLLLRLHLAISPSYIHPDEHFQGPEYALGNLFDWAHETTWEFRGDSPIRSFVPLWILYTAPLSVLNFLWKGQLSPREAYWFIRAGHALAYWILGDMALDRLSDSKKSKTKTLYLVGCSYVTWSYQSHTFSNSTETLLVLWCLVIIKESQQRHSMHHQRVHKFMDAGLLGLLIVIGTWNRVTFPLWLIVPGLTYLRKYLIHNISSLILLIASVALTAFFVIHVDSVHYDLEWTITPLNSFLYNSQGHNLAEHGIHNRLTHLVSNLPVLLGPLLILLRTPSQYWKSLQFQSAISGVFFLSLFPHQEARFLMPAVPLLISCYDINAVPRRFTSAIFLLSYVFNIIMGFLMGTLHQGGVVPAQHYLSKHVDSGSHTVVYWRTYKPPSWLLGIPEGELEILDKDHPLGTNLFKRVTDEIENIQIRHKKTMVTVLDLMGSSPEYVNDVIAALAPINPLLVAPVAGLKELDLPAYKEVWKTRFHLGLDHIDGLESLEPGLVVLEVL
The following text describes a protein:
Function:
Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores.
Subcellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment. Nucleus.
Sequence:
MILSTVQIDRIVLSMPSGRTTMDQDNKPSSSLELPASLDPNESIDLGNGSPDADTPVQEETGTLQTPSSEFGTPELDTPSSADGMGQGVKDSLERKSVTSDTDVASTGQMSDIPGNLEEVAIDFDSPPDTEGDGLDELQPSSSVDTFPSPTDVDNQMAPTPEVEVACDLELTSSNQLGVAESKSEQFDPVMASFDQKKLDPLGLQQPPFEMGLPVNPSEPALFKSVQSGVDLAKFDIQQALSEDQVRGQEVRGQEEDSTYDGIEIPSKNSHSGSGNGATPPATYDNEGFLLQEVGSPREETQVVIHVFNEQQGDLKKDSAMTPSVSSFFQDAPVTGKDTEGSSFFDSLSSQPAEKSGQEQTDGSCVSVQTNKEEQASQQTLHTTPRQLSHDALLHEIDQELQKEGKGAPKPQLVEDAAVTQVSTTELSQNVADLQGVKEELKDSNFPEKARAFSVETAQEAFESEGVANQKATVGTTHALFQSAPQGPFGGSTEGTFPGEEDPFTAVINMSEMDRRHDAWIPSERTRKTLVAIATSPPGTVMLEKDQLTMPGIMVDESQGDPIQDLMKKSLGEQEASKRQSLSVDSVSHNEQGLKHLIVTGNLRAAVDMTGRLLAQSGQGMGMAGQLSRHTPHSLQLWFTRIALLVRLRMFSTAEAELEAFGSLDQPDLYYEFYPDTYKGRRGTMVPFHFRVLHAELPQYLGKPHEALDRLYHLLGTCNQVVTNLEKGVAEDGSMLVLSPENRTASLQLWKSREVRVQFSITNCAVVLKDFNLAYETMDTILSQEIGDTPQILSAMGRIKLQLGDVRGAQQCFEKAEPLLEDEEDGEAVKTTNKAFLALGQGSFAESCQLFEQVYKLQPDNGVAINNTAVCQLYLGNLKEALKMLENVVQEDPNRFVQEGLLFNLCTMYELESSRALAKKHTMLDLVGKHKGDGFNAQSLKIA
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of glyoxylate to glycolate as well as succinic semialdehyde (SSA) to gamma-hydroxybutyrate in vitro. May function in redox homeostasis and play a role in oxidative stress tolerance by detoxifying glyoxylate and SSA generated in glycolate metabolism and GABA metabolism, respectively.
Sequence:
MLILARGANYSHHYASMAASFCPALPHHLKPTPISRFPKVSFSFKVFSSQTSADENPTRVGFLGLGIMGSPMAHNLIKAGCDVTVWNRTKSKCDPLIDLGAKYKASPGEVAASCDVTFAMLADPESAMVVACGEQGAASGMSPGKGYVDISTVDGPTSTLINAQIKETGALFLEAPVSGSKKPAEDGQLIFLTAGDKSLYDKVSSYLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMTSFAEGLLLGEKVGLDPTVIVEVISQGAISAPMFSMKGPSMVQSKYPTAFPLKHQQKDMRLALGLAESVSQSTPIAAAANELYKVAKSHGLSDHDFSAVIEALKVKIKD
The following text describes a protein:
Function:
Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.
Sequence:
MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1-alpha position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR). Has 1-alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway. Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin.
Subcellular Localization:
Mitochondrion membrane.
Sequence:
MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERSINLQFVDR
The following text describes a protein:
Function:
May facilitate 5' splice site recognition in the minor spliceosome. May be involved in interactions with components of the major spliceosome bound to the pyrimidine tract of an upstream U2-type intron.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Has no effect on the assembly of the protein into snRNP, but reduces the affinity for SR proteins.
Subcellular Localization:
Nucleus speckle.
Sequence:
MSGGGNNVVNKVFYATSYHPIQAGSIDGTDVAPHDNGVRRALLCYNAGLYDPSGDSKAVGDPYCTLFVGRLSHHTTEDTLREVMSKYGRIKNLRLVRHIVTGASRGYGFVEYETEKEMLRAYEDAHHSLIDGREIIVDYNRQQLMPGWIPRRLGGGLGGRKESGQLRFGGRDRPFRAPLRPIPHEDLKKLGIQLPPEGRYMSRTQIPSPPRRKGSVSDREEEYYREKSSVEREEEFKERSSLRSYHSHRSSAHTHSSHRRRSKDREECSREESRSDRKERARGMEDRYGDNKGEVSGSKRSKRSEEDRSRKRHKHLPSHHHRRSYSQDHHSSD
The following text describes a protein:
Function:
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
Sequence:
MRPLKKNRGRSPSLTRGRGGRRKVGSHALHEKDSKKVKKEMSVKAAQHTPNIPLKRKRSPPTVPNSIEQPITLSNINMKEEPTKLRNHTESQKNEAKKAEEGTQKDKTVGTNGNSSLPTASVAFPTSLPALQPQATNHSPSIGSISSRKTATFKARIPKKKYTYEHFANNASVMTSIPTSSPALIQNSYCDINSKVSNTANTKDNNFKNSKDFSSHVNQSFNFRICTSTNSNTICGTTTSKTSSSTSSVGSYSTYINSKSNNCSGNPLSVLTVDSKATEVNRIVFVDDKTLRTANAQEKEAQGGENAVDGTPNSVRSYSTDTASEHSADLDVIEATGPSTHILSPLHNAQQQEMSLSEGLAETLAKGMKNQRVLARQKNRTVEAVRNGDGCHPSSVFSPGLVRRVSGETVEIVLHGEDTLVKYPFHGGPMTSPSRTERIVDFILDTPPPGTAPVAVGTRVCVPFGGEEGGCLFYREGIVARVDPHPGVSFPYQVLLNEESESRRASEETEKSKVNGKGVWVSRQSLRLLAPPWEVSHLDGGGAKEREREREREERERREEMEVEREVCQLSIGMGVLGGHDFSHDGGTGVHSFGPSSSSVTSSVVVITDPGCGDGFSERQREKKMATPEEDVEVSHFNRVHTAGPKPNPPHPRNITSKASDHPTFSPHLSVVGGLGPPNLSTISNPQPTPSPVLQISEMNSIQTNLPPLKTTPTQTPTPTSSVGSSSASSRCRTPLSLAQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSREGCMKESQRRGYCSRHLSMRTKEMEAAGGEKGGGGGNSSGTVTPSDLLRQASSEFEWDETSRESSEISSRGDSRPRLVLPSLLPHELSSRFDFDECEAATMLVSLGSSRSGTPSFSPISNQSPFSPAPSPSPSPLFGFRPANFSPITASPVLQHRRPRQPSGTGGGGGGGGSSKVAIPGGGAEREKHPSGIHSSFHNNLTFTVPMSPNKRKPDAPPPPTLPTHHHDYTPKTELEQVDLNNSFRVLSPQTPASHSRSHTPTFSRPKGGTTLSASRPSSSTAVSPPPLLVSPTPPSTLSTEGGPRRVVHVSQQTLRDSPVIVRNPEVPLTKFTETPMGRGGGADEGETDSTSSQDVAPTPLNSHPVSGLQVPVPINRAAATVPNNAVLLRSPAQTLLLVSPTPSALPGFDPSAPVPQTLSVTVSTTVSAAATTDTDSSGEREDNRGSGFGTGVQQPVPCHPSPTALLPLILPAESLHPVPRKDIIMGRPGTVWTNVEPRSVPVFPWHSLVPFLAPTQSDASPQPEEGQHPVNHPQAASLKTECHGAASLSQEPTEVPPTVERVPPTRPLPSSYEPLPEKEKGDAERERPDSETESDVDDPFLPGVVPEPPITTSPVKRRTQSLSALPKDGDKNSPGKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEGRGVPGAKDIRERSMSESTEPHSVELKGVGPGLVGVSERSTAEEHVGQLTRPRAFSQSAMHSLGDRGSNTQALAELAQMCGERGGQFSSHAPSLSQNQRGVSEDMTSDDERMVICEEEGDDDVIEDPYPSSSIDLKCKERVSDSDSENASGDEGGRKRVFAPVICSSASSSSSHHTPHGRSVSLSSYPSSKRYDEGRSGGGGLSDHRRKERREGEGKDNFVVEGGRSVQAPPLSLSSGHSVISTSLAGGPPPSSAGSLGTNPLLGIGTVRVASTAVTNVMRPVISSPLPIASKPREGGSSSSPHPPERKSLTPQQQPQLLFSPGVGGGAAATGGGYYSSSSPNPAGAGGVVTNLVLGGALPAQSAVQLITPSPPSQLPHQQALPSTAVSATHSQSNGPLPVPLIQPQFLPASSLAPPGGKAITQVQYILPSLPTNTNPKSPPQQLSQPTSIFNLPTAPPTHVSLSNGKQQGASLPAGAVGVVSPGSRVQTQSPVLQGKMLVPMATIRTAPAPVQQFPIVTPPLPVQNGAQSGSKIIQIAPMPVVQSQLPQGGAVHPASAFPVTVGTAAVVAPGSAPSQTVLLPQAPTRITYVQSTPGIPSTLPLVSTTTGSSSSQQALPVPGSAYVPSPLATLGFTAIASPGHTLVQPLIAGQPPLLAAAQTPQPPTSAPAAGSGSPIVTAIYPPSPSVTMATGVVSMAAVPPSVAYTVSSSSSVSTQILPKHPPTLSAVAPHPQPHPDRQADRQPPADRPADRQNDRQAELPAHSERQLDRQLHTSSSGSSVAPPGGSAVSLRPCSPALQIQIPGNPPGTPKLLQPPVRNPHKVKATIATIPVGSYDGGGRGKDRERDKEKEREKDKEAGRETASNSHFSFDPEPLRQTGSPSAPPTEEPTSLDRPLEGSSTTDSADTRNRESTTTKEAAWKEQESLPSPPLPPPSTTEPALPPPQTDKDTLTPKRIKARPPPLKKTFDSVDKTGRVLSEVYFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRRKRKNSTDLDSATDEQLSPKRKSRRRSSCSSEPNTPKSAAKCEGDIFTFDRAATDGEDILAELEFEKVPYSSLRRTLDQRRALVMQLFQEQGFFPSAQATAAFQTRYSDIFPTKVCLQLKIREVRQKIMQTATPSDGSGLGPSDSSFSLPGPSGSHSGDGSGRGGDLQDDEAEQGAQASPEKPRDPHESAR
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAFLSQLQGGFAQLKQKAEAAAPSIAGSLNQLKEAPKLVESAFKSGLTKVKLDSLGKVLNVPSLGRSQSPIDIVPVITAFGEHLQNAHFEVAYESTGEFKAGNDGNSVWLLREGNSSELAISFLAEEQYHLDAVNFHWATEPMNGSEHTIGGVGYAGEMHLIHRNTRFATMADALKQPNGVIAIAVFLNESHDDNPVFSPFINLLPQIIYKGSECKLCSFDFQTFFPVAEKTKEFWMYEGSETTDPFRETVNWIVIRAALPISSHQLDKLREVRAGRYDEEFSDKVPMKPLRQIQAASSRTVLSSFRSVAGAPDLGFRQ
The following text describes a protein:
Function:
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MGSSREYESEKTMIKPVGMSIAGLDTGNGAGGETDLRVFEVLGIHGVFAITAITAQSTKGIKDITVVNPEFLKKQIETLLEDFKVEAVKIGMIYTKEQFQVVNELLNDYFLVADPVLYAKDGTPLIRDIEEYKKIILPKVKVITPNIIEASAISGVKIEKESDVVIVCKKLRDSYNIPYVIIKGGHSKGDYSFDYMCNDEGLYKIGYKRLQAKDTHGTGSVFATALTAEYIKIRDLKLAFRKARDFVQTSIEYGLNIGKGIGPVNVSVEIMKKSMKYEAVEEMRRFADFAENNDRFWILIPEVQSNLAHSIKPEYVRDLNDIATFRGRIIRRWDKKVIVGHPVVFGNPTHTARMLLSLILKGKDSTCLMNIRYDDKIVESFKRIGYETIEINRELEPAHGEGKTMQWIIEYVSSEYGGIPNVIYDKGTKGKEAMIRFWTKNMEEMIEALDNLLKML
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKNTQVKFNENDVFHQLFWFRRLLALPNAQKLNTSYSYLFHVVGMIFLLLVLFVWSLFNKCKAWKEFSSLSVFVFEVVTLIILTLFSLVTILFTNFLRRKSFKVLMENLTELDHLMNNLQFRKRRKCIFIELVTVHLVFVFLYIYDIYTSVISFESNTYIFKIPDFINQYVMTLEVVTMCNYAQAIKCKFKALNLSLKKYVKSSVQNSSMNCDLDKYMDMHSKLCSTISTFNDCFGVQILGVFFVGLIATTYGAFIFLLYASGNAKISYDVSVFYRLMLFLIFICYFMLLGIIITVSCVATAWTGRHTATVCYKQLLQTLPFPKSLCERTLKKELLALADQVSQRQINFTACRFLTIDFKTLCTLFGSTAMNVIILLQFKK
The following text describes a protein:
Function:
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
Domain:
Binds RNA through its KH domains.
Sequence:
MPSGSSAALALAAAPAPLPQPPPPPPPPPPPLPPPSGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAPAAAAQGQARRAAELSPEERAPPGRPGAPEAAELELEEDEEEGEEAELDGDLLEEEELEEAEEEDRSSLLLLSPPAATASQTQQIPGGSLGSVLLPAARFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS