lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MRSFLQQDVNKTKSRLNVLNGLANNMDDLKINTDITGAKEELLDDNNFISDKESGVHKPKDCQTSFQKNNTLTLPEELSKDKSENALSGGQSSLFIHAGAPTVSSENFILPKGAAVNGPVSHSSLTKTSNMNKGSVSLTTGQPVDQPTTESCSTLKVAADLQLSTPQKASQHQVLFLLSDVAHAKNPTHSNKKLPTSASVGCDIQNSVGSNIKSDGTLINQVEVGEDGEDLLVKDDCVNTVTGISSGTDGFRSENDTNWDPQKEFIQFLMTNEETVDKAPPHSKIGLEKKRKRKMDVSKITRYTEDCFSDSNCVPNKSKMQEVDFLEQNEELQAVDSQKYALSKVKPESTDEDLESVDAFQHLIYNPDKCGEESSPVHTSTFLSNTLKKKCEESDSESPATFSTEEPSFYPCTKCNVNFREKKHLHRHMMYHLDGNSHFRHLNVPRPYACRECGRTFRDRNSLLKHMIIHQERRQKLMEEIRELKELQDEGRSARLQCPQCVFGTNCPKTFVQHAKTHEKDKRYYCCEECNFMAVTENELECHRGIAHGAVVKCPMVTSDIAQRKTQKKTFMKDSVVGSSKKSATYICKMCPFTTSAKSVLKKHTEYLHSSSCVDSFGSPLGLDKRKNDILEEPVDSDSTKTLTKQQSTTFPKNSALKQDVKRTFGSTSQSSSFSKIHKRPHRIQKARKSIAQSGVNMCNQNSSPHKNVTIKSSVDQKPKYFHQAAKEKSNAKANSHYLYRHKYENYRMIKKSGESYPVHFKKEEASSLNSLHLFSSSSNSHNNFISDPHKPDAKRPESFKDHRRVAVKRVIKESKKESSVGGEDLDSYPDFLHKMTVVVLQKLNSAEKKDSYETEDESSWDNVELGDYTTQAIEDETYSDINQEHVNLFPLFKSKVEGQEPGENATLSYDQNDGFYFEYYEDTGSNNFLHEIHDPQHLETADASLSKHSSVFHWTDLSLEKKSCPYCPATFETGVGLSNHVRGHLHRAGLSYEARHVVSPEQIATSDKMQHFKRTGTGTPVKRVRKAIEKSETTSEHTCQLCGGWFDTKIGLSNHVRGHLKRLGKTKWDAHKSPICVLNEMMQNEEKYEKILKALNSRRIIPRPFVAQKLASSDDFISQNVIPLEAYRNGLKTEALSVSASEEEGLNFLNEYDETKPELPSGKKNQSLTLIELLKNKRMGEERNSAISPQKIHNQTARKRFVQKCVLPLNEDSPLMYQPQKMDLTMHSALDCKQKKSRSRSGSKKKMLTLPHGADEVYILRCRFCGLVFRGPLSVQEDWIKHLQRHIVNANLPRTGAGMVEVTSLLKKPASITETSFSLLMAEAAS
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MNVNFRTILGKTYTITVQPNQTLTDAKRILSVQEDISLEKAQFIYRAEILQENIPFSTLQIQQDRYIVIHNSSPKKATPIQPPPVENNPPNSELDSFEPPNQATRPPLDNIIDESDEFNRDVKALVEMGFTKEQAIQALRTTGNNLDSAISLLVSENAPIPEEILAMNNSPSQQPPPNTRPPPTVESSNSGQNTGRYRDFQGDYDKLSSSEKEALERLDTLGFDPTTTIQIFIVCGKDEEQARNCLSSLR
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
QSFLVIAGKFGKTQVYRFNRSKSLYLFGPENPIRQFSLKLITNQYPLQLHNRHMFVLLTILVNCVFLAMTNPPEQPEYVFAAIYTIEMFCKIIAKGFALHRYAYLRDKWNWLDFIVVILGNVTISPDVANLSGIPTFRVFRALRTISAVKGLKAMVNTLLVSMKMLWDVMVLTLFFICIFALIGMQLFIGELRNKCALPVPENLSVPYRTYASNSSIWYLEDNEPILCGNTTGSRTCPTNYTCLPHAGGNPNFGYTSFDHFGWALLTGFQLITLDFWENVYNNVIYTMGPWYVVYFAVVIFFGPFFLVNLVLAVVAASYENEVKASKMETEEERKEQKRVASSYSVRRASILSIVYGQGDVIPDEPNSKGLYDIPVVTCSEVTKSDEEALSVFQIRQESGIQNQNLTLHQNWIGSRQPSSVTLPSLKPEHALHMNGSQRSNLNHTSDIIGSQKSNLNNASQIISSHKSSLNLSVKKEEKKRSSIMARRWKRFRRRLLKFTNGKVMEIFIIVCILLNTLVMSIEHPRLEDPLLTVVNISNEVFTFIFLLEMILKLIALGFLGYIRVAWNIFDGIVVIISIVDFIVNKFVPDAGGTGISVLRTFRLLRVLKLAKSWSTMNSLLATIGKSLGALGNLTVILAIIVYIFAVMGMQLLGNSYTPDKFGGSIPRWNFKDFPHSFMMIFRVLCGEWIEPLWDCMLATGPVAMLLFVPAFILGNFIILNLFLALLLSSFASESGTQPKKKKRKRGGGGDWRECQHGRGGRGGRRRARYVQQTQGKEYPQYYLTDYPVEPCFPTSWCVCRLACMDSGFCAVWKVMRYKVRRLVEHKVFEGIILFLIAASSISLAFEDVYLDSKPTLKQVLQILNILFAVIFTVEMLLKWIGLGFKTYFTNPWNILDFVIVIVSIMVSLATIFGNDQIAFIRSLRTLRAFRPLRAISRFEGMKVVITSLLHAIPGIGNVLLVCLMFWLIFSIMGVQIFGGKFGKCVDEGGEKCPASVVPNKTVCLSNGYRWENSNINFDTVDQGFLALLQVATFEGWMEIMEDAVDATKIDEQPIEENNVSAYLFFVVFIILGTFFTLNLFIGVIIDNFNQLKQQMEAVGSMDVFLTSTQRNWMNALKSAATKKPKKRIRRPQNKFQGELYDMVQSRKFEVFIMLFITINMVVMMVQHYDHLAVWSKQILNLIFTSVFILEAILRIIALRKGYFLNPWNVFDFVIVISSIIGIIVENLQTSLVINPSLLRVVRVFRVGRLLRFFEAARGIRRLLFSLVISTPALFNIGALLFLIIFIYAIIGMSIFGHVKKTEALNDVVNFETFGSSFVLLFRLMTSAGWNDILDPLMISEPDCDPNYRGLPSGNCGNKYMAPIYLGSFVVIIFLILINMYIAVILENYNQVMEQEKIGITNEDIELFYQMWELFDPNATQYIPYADLSDFVHQMEGNLRIPKPNKAACALLNIPLVKGDKIHCLDLLQALVKRIVSGFEDVDSEGFKIVMQRMEERFQAAFPSRTGHKSTITTMEIKRHQEAAKVIVRAIRGY
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MDNEKPIVDFGAIRDVLGKDFEPVQVLDGQAKVIKPEIVSKYSNEQLVEFFKLMLWERTLHQRSNALTRQGRLGFYAPTEGQEASEMGSNAAMKKTDVLMPAYRDIPQLIQHGLPVYKAFLWSRGHVLGNEYPEDFHAMPPQIIIGAQYVQAAGVALGIKKNGTEDKVAYTYTGDGGTSQGDFYEGMNFAGAFEAPAVFIVQNNGYAISVPRRKQTAAKTLAQKAVAAGIPSVQVDGMDFLAVYEVTKAAREYAAAGNGPVMIETLTYRFGPHTNAGDDPKRYRTKDEEQPWFDNDPLIRYRKYLTDQGVWSEDQENEYVEQVKEDIKAAVKQADEAPKQKMTEFLGNVFEEQPQNIQQQITEFQAKESK
The following text describes a protein:
Function:
Absolutely required for transposition of IS1.
Sequence:
MIRHMSVLLGDSSTGNWELGNRDSQTLSRLLERLAKWKVTVYCTDDWRPYQQLLDEHPDAFHGISKRETVGIERNNSDNRHWFARFHRPTKVVSRSAHMVDITMAIFAEFRVNGNIELLRNWRLSLLS
The following text describes a protein:
Function:
Receptor binding subunit of the a-agglutinin heterodimer. S.cerevisiae a and alpha cells express the complementary cell surface glycoproteins a-agglutinin and alpha-agglutinin, respectively, which interact with one another to promote cellular aggregation during mating.
Miscellaneous:
MISCELLANEOUS: Present with 1160 molecules/cell in log phase SD medium.
Sequence:
MQLLRCFSIFSVIASVLAQELTTICEQIPSPTLESTPYSLSTTTILANGKAMQGVFEYYKSVTFVSNCGSHPSTTSKGSPINTQYVF
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Sequence:
MEALERFRFITSATAGSRRVKKNPPPAARKKSRVGLLDGDEADIEELAVLASNAGNSGVSIISDGGFGAMPPLQGANTSAECTGEVLGATGVDDSPERKFGAKSNQRGRKAGRGAFKWGTATAQAPERWKEVLDGIREMRTARDAPVDLFGTRQCVDPEADLETQRFQALVAAMISSQTKDPVTAAAMLRLRALPGGLTIANVASPEMSVESLQGTLHPVGFFRQKGAHLKAMAQKLAAAPHNGRVPSTVNELMELPGVGPKVAHLTLVVAFDMPEEGLIVDTHVRRVCERLGWASPDRTPEQTRLAIESWLPKAQWAETSLLLVGFGQQVCTPLRPRCGDCRISALCPSAFRDLATKTERKQGKSRAAVKRKKGETSEATANDIRP
The following text describes a protein:
Function:
Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC; Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity.
Sequence:
MIEKKALQELDFYKILGLIEEFAGSEATKKAIQQIFPFDEFTSAENSLKEFEEIKRYFDTGGQLQISSFPDIANLIEKAKKEGAFFEPSELTQFLKVLRVLDKISSYIDEFFNFPFLSQKIKNILKTNLSIGQPYILERLENTVDEEGNILDTASSTLKYIRKQIKLTEEKIKQKLEEIINRSNVLVFLQDRFITKRNNRWVIPVRMDSKGQIPGVVHDVSRSGETAFIEPAEITAFSKKLEELLIEQRLEEIKILKELSFEIHQISETLHREFNLLVYLDKMLSIYKFSQKFNAEAPQLTREINISLINAKHPLLLLSKQVVPLNLELKNKKVLVITGPNAGGKTVTIKTIGLLTAMAISGLPIPASPSSIIPFVKNIYVDLYHEGSIEEHLSSFALHIITLKKIIEQADSESLILLDEIGTNTDPEEGSALACAILEELKNREALTFATTHLSKVKIFAATQQNIEIASMLFDEKTMTPLYKLSIGSLTPSYALEVAQKYGFPENLIRRAYELKGTQDREIYELIKELEKNKQEYETKLAEIEKIKNIMDSEKNRLEKELVFASENKKKIIEQAKIEAQSMLTKLKKEINFLYEEAKKADRKKLREISQKISDISKKFISEEPKKQEELNPGDIVKIRNLNLSGKILIIEDGRAKIQTDTAQIEAELRELEKVSFHEEQESNKRLDIFSVTNKKAIENYKEEYPSKKLEIRGMRVDEALPLVERFLNELSFSESNRGIILHGIGKGILRDAIRDYIKDHPAVKSFRKGNPDEGGDAVTVIEMK
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
MQNMMKHILHRPIHHCCRRAQYMHHPSPTTHLLLNRPISTLSTTHRHTHQSILPNIHPQHFYQIINNVNEYRNFLPYCQESKILQVSQCGSMMDAVLTVGLPGLSVGAASSLLEERYVSRVRMLQPKMIGGNVVEKEGCWNSSYSLPSSTTNNTHSCNVRFEVEIQVSNPLISFTLDRVLNDVARKQVEAFEKRCRNVSFDAGGR
The following text describes a protein:
Function:
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHFVAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLISSAVPMTPEDPSFWDCFCFTEEIPIRNGTKS
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MGGPSVGQPQGKGPAGAAGRCVYAHRNFKPPAKVLTMPMPKTSPSKTLVIVESPAKAKTIEKYLGQGYAVESSVGHIRDLPRSAADIPEKYKGQAWARLGLDVEHDFQPLYVVSPEKKQKVAQLRKLAAEADEIILATDDDREGESIAWHLYQELKPKVPVKRMVFHEITREAIQAAIAAPRQIDRNLVEAQEARRAVDRLYGYEVSPVLWRKVAPKLSAGRVQSVATRMLVERERERMRFVAATWWDVVVTAQALTAQAGEQTFPARLTEVQGERLAAGKDFDPLTGQLRPGAGVRLLGEAEALAISEGLKGQTLKVLTAEEKPFTSRPPAPFITSTLQQEGSRKLRMSAQTTMRTAQRLYEGGYITYMRTDSTNLSSEAVNAARGQVKDMYGAPYLSPQPRVYAKKSKNAQEAHEAIRPAGSTFRTPEQLRGELSGDEWRLYDLIWKRTVASQMSDARGRSLRVRLGGQTASGQTADSVPVVLNASGRTIDFPGFLRAYVEGSDDPAAALEDRDTPLPPLKXGDAVRAQDVKAEDHETQPPARYTEASLVQALEGAGIGRPSTYASILGTIQDRGYALKKGTALVPSWTAFATSALLEHHFGTLVDYDFTAKMEEDLDEIAGGREHRVPYLRRFYLGEEGEGMALKPLIERQMGEIDARGIATIKVPKLEGSGIEVRVGRYGPYMQRGEDKANLPEGMTPDELTLEVAEELFSRPQGDRVLGEDPESGHPVLARAGRYGPYVTLGNENPPLRSASLFPGEKLEDMTLERALQLLTLPRLIGTSEGEEVWAHNGKFGPYLKRGSDSRSLATHEQLFTVTLPEAEALFQQPKFRGRGVAAAPLATYEYEGRTPILLKSGRFGPYLTDGEKNATLRKGEDLNTLDPQRARDILEERGKEPQKKPGKAGTKKAAASKAPAKAAASKTAPKKAAAKPAAKKAAPKKAASKSAKTPAAKAAPLTWAQLKPFVGVLSEPERALVTATREQGRKVEDVAPELGLDVKKAKGMALQASKKLNQAARGG
The following text describes a protein:
Function:
Probable 3'-5' DNA helicase. Required in synaptic and/or post-synaptic stages of recombination. Probably has an overlapping function with RecQ. It probably acts to help generate ss-DNA from ds-DNA breaks.
Miscellaneous:
MISCELLANEOUS: The stop codon of ypbB overlaps with the start codon of recS, suggesting they are translationally coupled (Probable).
Subcellular Localization:
Cytoplasm, nucleoid. Note=Probably targeted to the nucleoid via its association with YpbB, which itself is targeted by SSB (ssbA) (Probable).
Sequence:
MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGKSLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEHIHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRKKLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKIDRVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFIHNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRAPGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIHLFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGNLPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN
The following text describes a protein:
Function:
Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MKKNGCLLLFAYSLLSFSLTAATIDETYDESLFIKSFSSRYSYVSFAFEIGASTDSTHSSVFSESSFSLFPLSIARVMDECQVSELHIRATRGRWDYENWKESPDNGFYSGGLGFEVWAFMANDPSMKYWLKLTNQLSGLLCASLNYIDSSNTYQPQLSYPGSFSFSNNTQYFASLPQEDVCTENLSPLFKLLPCKRKAGIASLLDSHLFFDTDWHSFSIDVYPSENQSLASVKMGIIIQAVVDVERNGRRKGKTTFQPPSEYCHDEDMDSLHCLMSGYSTEHHTVDDLFHKVPKERCLLSSTFSDVFVSNGDKIDTFSLDEAANIQIPIQSTSDNHTVTVDRSLSNDGNHWGSLSSTIYNPSSSPRTIVYFEKFPWFVRVYLHTLTITLNGTRINTKDFIEKLYYQPLRDRKAGTMMEIQFSIPPHTNLIVHFNVEKTPLRLDEYPPDANRGYNLPPAIISVFDENNTKLCSLRTAALLMFIPTPDFSMPYNVIIFTSTVIALTFGGIFNLLTRRFVPQQSKFQNRQPSMLQRLKEKIFHKKRG
The following text describes a protein:
Function:
Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases.
Sequence:
MVPVLVVFSQSHVDFRIPEFEAICSMLSIRVKNMNSINTENHMFVLHFENRLDVTKLLSRSILIKFAISLSVEAQSYEQLFHELKNKPEVIENYDVPDESFALRFFAIGRKKKLDSIERIKMFLEAVQFNHAPICLISPVNEFYLVEEYDHPTDENPRKIFFGKLWGEGRSELKTKYNLRERCYIGNTTMDPELSFIQVGFPMHLCSLIEHLKANLAMVQPGNLVFDPFVGTGGLILPAAEFGGYVMGTEINYQTARAKGRSSRQGVGERHESESIRANFEQYYTEARFQNDKLLSIVIADSSKHAIWSSNAKFDVIVADPPYGVREKARKTVKNKKSDANEDYIQYQQKEDYDLEAAFCDLLNLAAMALVMNGRVSFWYPVILEKYCSENLPTHPAMELLSNCEQPLTRKTSRRLLSYRKVREPIANEECEIRKTGVSHYRDCLFSSNKKENC
The following text describes a protein:
Function:
Phosphoglycerate mutase-like protein lacking PGM activity, but having 2-carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase activity. Prevents the accumulation of D-glycero-2,3-pentodiulose-1,5-bisphosphate (PDBP) a potent inhibitor of ribulose-1,5-bisphosphate carboxylase (RuBisCO). PDBP is produced during the oxidation of ribulose-1,5-bisphosphate, the substrate of RuBisCO.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MISLPLTTPILPSRCLLHKTRRQNSTRRRLLIRSSSSLQDQFTVETTKRVVLVRHGQSTWNEEGRIQGSSDFSVLTKKGESQAEISRQMLIDDSFDVCFTSPLKRSKKTAEIIWGSRESEMIFDYDLREIDLYSFQGLLKKEGKEKFGEAFKQWQEDPANFIIDGHYPVRELWSRARSCWPGILAHESKSVLVVAHNAVNQALLATAIGLGTEYFRSLLQSNCGVSVLDFIPRADGGSPHVCLNRLNQTPNSPLAGGSSGGRKASKQIILVCHGQGNNEDSAVINQAANNDQAMNMLGVIHSQKTAELLLDLRVSSIVCSPKTASIESSGVISRVQEAAGCLGVDNVPHYVKTKQMNELDVESVLRKSNKDNDVIASQLDEEAFSALWNRSEKAWESLLDELSDEKSNPGEIMVVVGPAMTHISLIAQCLNLTKEALGLFHLDAGSISVIDFPDGPSSKGVIRCTNYTAHLGRWSIPITKPA
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as well as inorganic polyphosphate (poly(P)) as a source of phosphorus.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAHRSVLLVVHTGRDEATETARRVEKVLGDNKIALRVLSAEAVDRGSLHLAPDDMRAMGVEIEVVDADQHAADGCELVLVLGGDGTFLRAAELARNASIPVLGVNLGRIGFLAEAEAEAIDAVLEHVVAQDYRVEDRLTLDVVVRQGGRIVNRGWALNEVSLEKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPEATIAIEIEADGHDALVFCDGRREMLIPAGSRLEVTRCVTSVKWARLDSAPFTDRLVRKFRLPVTGWRGK
The following text describes a protein:
Function:
Cytoplasmic form induces gene transcription inhibition; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Nucleus. Secreted.
Sequence:
MSANFGHSSQPVFMVDSAGNHPKQHRYYHQQVPRHPEPPLVPCWTFPPARVEMKKKGWGGMNAGLAWVVTLILLLVFAALGLGAYQILRLQTKLEQLTQELPTIMQSSAPQKQVGLNPAELKKNKYKSAAHLIGYAEQSKSPGLLKWISNHGDAFTDGVKYTDGGLQVNETGLYFVYSRVEFLSHTCKTFDSLAHKISLKRNGNSQIIMEDNIEGFCMTSKNHPWVTGSQLGSLQQLRELDWLFVNVSRPHLLSKNFHSNYFGLFKIH
The following text describes a protein:
Function:
Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.
Subcellular Localization:
Nucleus.
Sequence:
MSSLKDCKLSKSKREELKALNNAGKTPRRVKVYLLNGDDWIDNGTGFCVGEIDDDTKLPYFLVRNETDNNNIILKSFLEGSIQYQRQQETLIVWTDSNGTDLALSFQETEGCADLCDFIIRVQQGNISPGISLYYVIPNINEGDDITELITGPIRYPPEIPNVENLDVVLETINQGTNAQFTRTNISEFIIENDYFTKLINVFNEAENNENANVLYNVSDIVKSLFLYNESSIIEYILSSEEKILGLVGILEYDSEYPNYKASHRNFLASQSYIKVIPVENIEIFKRDFYLNYLKDVVLARFLDDSTFNLIASLIYSNHLEIFNYIKDSEILEHLFSIYDNCNDEKNECNSIDNDDDNDDDNIKMKQRDGVKMLHQYVLIAKSSRKHDFFASLVKHGLLKMINFALNDKQDQIRVLGTELIVIIIEQDVSLVNSIDHEETTTTIDNSDPPILEELVHNNKATPQEIVEEEEEDIPSITPKEGKLRLSDDMTLISILSKLLVEDKNIGLKMQAFEALKTLLDPNIAASSSGGSNGLSPTTMGGMGTPNGSGSGSNSNSLFNSSNANANANANTNTNTNSVNKSIGINTNNIEEFKFTSEEFQEINTSTYFRAFYEQVAPKLFEKLIILANHNLESKQLQINTKHEELLYQLLCELISFCTLEHKMISLSSLSSSSFSSSSLSSRSFFIENHIPLGIAKLLIIDDCKPILKLTSIRCLKNLILLNDEFYTRYFINHDLWFYFFKFFNNVIDENNLANSTCLDFIEIVIKGCDIGLNNNNNNNNNNNSKRSNYILLAKHIYKKYGEFIEKKLNYVDTGKRLIDLVTHSLNSNSNSNVNKLNGGQTFNENNNNNNKEEYDEDDNEYDNENEDSDENIATNTDDLGLSEDEMLPHNASTPLNDEEDEAEQEGTRLYTDVTEEIRISEKKRPREESDEIKPTPIIDNATTTTTTTTITTTTAASNSNDNFNGTKKIALTTTSDNQS
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MLNGLIYLAFFIPLSGFFSFAALVGSLVDASGGFAHRCALAWSRIGLMMAGVRLDVSGTENVPAGEPVIFMGNHQGNFDILVLSRAIPRRFSWLAKEELFRIPLFGAAMQRAGYIPVDRSDGRKALRSLDAAAKRIRAGASVIVFPEGTRTADGSLLPFKKGGFVLAERAGVPIIPFTINGSMQVNPRNTVKLVRGARIAVRFGTPIPTSGAGALKGTPLMEQVRSAIQSGLEG
The following text describes a protein:
Function:
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MVTIALGSRNPVKINATKEALDVLKLNWDLIGIEVDSGVDKQPFCDQTYVGARNRALNVIRVTNADIGLGIEGGVCNVYGKFIANAVVYVITKEGLENFAISSSFTLPSSMVSLILQGKELGEASDIIFKTNNSKTKEGAIGLLTNNVINRKMLYVQPIVLALYPIYNTMINNTPF
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASEGDSIDYYELLGINEDAQDQEIHRAWRKTSLKYHPDKNPNDPKAAEKFHMLQLAYNALIDVQLRKAYDSERFAKLARKRREEAFNFQRKSMVDDLRERERQFYDSLEKKENERDRLQEKLRALQEESANLRRQRENRLREEQEQSKRRKQETPSSKISELDRSIRIRWKRKYADQVNDAYLRSIYSSFGTLQNVVIQKDISKEKKYVYSIIVFETLSSAYSAINAEKPSKIYDVQWLKPPKSNSNTPTEKDTTVEDYEEITIMRMKQKHKQKQKENERKATSTMNA
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MRNYELTTITRVSSREVAKSEIQETLKKHSVSVTAEEDWGQRKLWHPIKHEEQGIFHHYKCSADPNAIEKVEKEFLINQNILRSMVVRLHG
The following text describes a protein:
Function:
FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
Subcellular Localization:
Cytoplasm.
Domain:
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Sequence:
MAFDGTWKVDRSENYEKFMEVMGVNIVKRKLGAHDNLKVIIQQDGNNFTVKESSTFRNIEIKFTLAQPFEYSLADGTELNGAWFLQDNQLLGTFTRKDNGKVLQTTRQIIGDELVQTYEYEGTESKRIFKRG
The following text describes a protein:
Function:
Not known; disruption of the gene for tipD results in morphological defects.
Sequence:
MFSSQNNSYMMMMGGGGIGNINNNQFYSPIISTSAQSFNSIVEWKRDIIRQLNDRNQNQTNNYSEFMRIYTDLLKRERTLNDRTLLYEKEIVSLRNEKKTQQQPPSGSSKMDSSSSSSSSNRVSGMGSTIEEMEQKLFKLQEDLTNSYKRNADNASSILLLNDKNKDLQNELMSKEIEIERIRSTIQQDLDSIKRLEMVVIEKENVSQIIRDELSSLQTEFLHNESKVVKLEQENSSLVERWLRKKNEEASKMNEANDFYQKMVEQRDSTPAKAAVQLSESISNLVVKLPDANDVPIPIVLERGVFSSEAMLPSKAKKRWTGHNSEIYCMAFNSIGNLLATGGGDKCVKVWDVISGQQKSTLLGASQSIVSVSFSPNDESILGTSNDNSARLWNTELGRSRHTLTGHIGKVYTGKFINSNRVVTGSHDRTIKLWDLQKGYCTRTIFCFSSCNDLVILGGSGTHLASGHVDHSVRFWDSNAGEPTQVLSSIHEGQITSITNSPTNTNQILTNSRDHTLKIIDIRTFDTIRTFKDPEYRNGLNWTKASWSPDGRYIASGSIDGSICIWDATNGKTVKVLTKVHNNGSSVCCCSWSPLANIFISADKDKNIIQWE
The following text describes a protein:
Function:
May play a role in the trafficking of a subset of G-protein coupled receptors.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRTVLLSKHDELYLEKCAQENQFSYGIIVGHQADLTKSVVVHLARNNEEDADLEDLSEVRLTISDINSQALASQWLSASKMCPGSFDVIGIFVSSVRSDVVNEQSAEFKNAKKLFSDIYDLLLKSNSSFGVYTTDIAQTDFVFLSYSLADKKVLCKNYSYGNGGTFTNMEFRFVDKPFEWIQLECSYDFDDVLPILDSSRRVNIEDQFQSMIVSVRKNLLASEVFLQNEVVEDTIDLQAYIKKKKTKVDKLQPTSTTGGTATASSNTTDSLPRLASEGIIGGTETIRASIVLPMKCQLSKPTDIKVREFSGTLHMSGIITSKVFCNPRNSIADVKRFLRDDVLRSLITRIQVYCDGLTDPYVTNEALYISEPPRRVFFSLPSEGPSASVGAVVQFSEYLFRGEAPTVVVAQAKQILDVDLDPETISVEAEGLPDDTHFNNCKMDADCIDDSGIMTSSMPKPELSRSLYMVGIAVALLVLLSSVALHFVLAER
The following text describes a protein:
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MRSLLLLTAFAAVAIQASPDEDRCRDRSCYPITGNLLIGRKHRLSASSTCGVHDRERFCIVSHLEEQTKCFYCDSRHEWRPYRDPYRLSHKIENVVSDSYETKNQAWWQSANGVQNVTVQGPPSKHTDVICTRSYSDVAPSTGGEIVYKAISPHIATDDPYSDEISSLLRVTNIRFNFTKLHTLGDDLLDYRKEITEKYYYAIYEIVVRGSCSCYGHASSCIPIDDQAAQFGGEDIVHGRCECTHNTEGLNCEKCLPFFNDHPWRPAVANNTHECKRCECNSHASTCHFDQAVFDASGFVSGGVCDDCQHNTQGKNCEQCKPYFYKDPRRAIYDPYVCLPCDCDKAGSKNEGICEGEQDEERGLVAGKCYCKMNVDSHRCDRCKNGYWNLTAENPDGCVACTCHLQGTWNNEGCNKHTGECTCKRFVTGENCDQCIPEHYGLSDEPDGCKACDCDVGGSLNNQCDVKTGQCQCRDKFGGRRCDKPEADHYCADIDHYKYEAEQANFTHGNVEVRERPKDPRGLSWTGEGFVKVNERSSITFKVGDIQTSNDYNIVLRYDPIRDQIGWENLEVTLIRPSDPSPDSSCANKDPSSDLLVARLHPGARYYEVRPSICLEAGVEYEIKLDFGDKRTNAPDRSASLLLDSIVLAPPTEKLDVFANLEDQRAQQHKMEYDRYQCRHQALSLTPKADLSDTCKTYTCTIAAAFIQKGLECGCDPTGSVSGICAPEGGQCECKANVVGRKCDKCGVGTYGFGPTGCSECACDSVGSLNNQCDKSSGQCVCREKGIYGRQCNQCQPGFWGFPNCAVCQCNDHATICDQQSGSCIDCHDLTTGEHCDRCKDGYYGDPRLGVGLPCKPCPCPGGPGSGFQHADTCYLQPATSEVVCQCSAGYTGDRCGECAMNYWGEPNDVGGTCERCDCNGNIDMSVPGSCDAKTGDCLLCLHNSEGAQCENCVEGFWGDAKNRQCQRCICNTLGTNTSSGACDRVSGQCPCFPNVIGTQCDQCALNHYNIASGQGCAECACDPTGVEMDHEGKPDLQCNHFDGQCKCKRGRGGRTCSECEDYFWGDPTTPDGCKMCECDRTGSMSLQCHRNNGTCVCQEGSGGPLCNECARGFTGQWPHCKPCGECFHQWDAIVQALKSQVETLILTANNIEDTGVASAFDADFEKMEKELDSTRQKLQDANVDKENIEKLQNEIQSLKDEVAKAQKKLESISGDVAETTQDIEFAEKDVKELEMKSEKLKKNADELNEKTNKIKESDVQGAYNMTKEAAAKSLEAQRKTDAVVGILAETEKEANEVKELVDRNRGDFDKQYAENEAALAECENNLVALEVYLPDLNGDVCGAKSAPCDSLCGGPGSCGKCGGQSCLEGAVSRAEQAKNFALEADLKLNEKQAEAEEVLSLVREVLSSTSTAQREAEEALTYGEEAARGTNASRQSTEEILHQITELITGNRSTPEDIRAAAESVLAMKISHTPEEIEELNKKIREKLGSVQNTDKILAETRGNLSVAANLEERAMRSAESAVAIKNTTDTVRDALKMAGEAQTKASDAIKEAEEEMKAAREDLKTAKEATDEADGKTKETNETLSTLEVDMKKVKVQYLQILDDAKSAYDMVDRSQEASSEAEAGNKQLARDMETAANLLNEKSSGKEKAQERAEKIRARAADLLYKLQKYDEEYRALAKFDASEAMEDYSNLLDDYDKRARQLTEAIEKRSDYYQNYGSAVASTSISYWEGIRRAASEYNEKREELKQLEEIIKEQSDAELVKMAKCDLEATTDSFDEAIDELARRIIPRTEVDVLSKCQMEFSAGAGGTEAMIFTAELFDMYRKYCEWRGWMWTPLEVDEVALGGMRAAIVSIQGKDSYASLRFEAGVHRVQRIPLTDKSRMHTSTSSIAVLPEPEEVSVLIPPQSVSIETMRASGPGGQNVNKRSSAVRMTHKETGISVHVMDERFQHMNMQIAYKRLAAILMQQRVDKMVDKFTSERKLQVGSKARAEKIRTYNFKDDRISDHRLHLNMSNIDEFMKGNEHFNSLVDRLSEMYEKERLNEIIKNRIFE
The following text describes a protein:
Function:
Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity); [Isoform 4]: Does not bind DNA by itself.
Sequence:
MCGDCVEKEYPNRGNTCLENGSFLLNFTGCAVCSKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDEFQEYTMLCLLCGKAEDTISILPDDPRQMTLLF