lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor that promotes photomorphogenesis in the light by participating in the transmission of phytochrome A (phyA) signals to downstream responses. Probably acts by activating expression of light-induced genes. In darkness, its degradation prevents the activation of light-induced genes.
Subcellular Localization:
Nucleus speckle.
Sequence:
MAKTKYGERHRKGLWSPEEDEKLRSFILSYGHSCWTTVPIKAGLQRNGKSCRLRWINYLRPGLKRDMISAEEEETILTFHSSLGNKWSQIAKFLPGRTDNEIKNYWHSHLKKKWLKSQSLQDAKSISPPSSSSSSLVACGKRNPETLISNHVFSFQRLLENKSSSPSQESNGNNSHQCSSAPEIPRLFFSEWLSSSYPHTDYSSEFTDSKHSQAPNVEETLSAYEEMGDVDQFHYNEMMINNSNWTLNDIVFGSKCKKQEHHIYREASDCNSSAEFFSPSTTT
The following text describes a protein:
Function:
Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. Probable component of a core structural unit of the scaffold that initiates synthesis of the prospore membrane.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the meiotic outer plaque of the spindle pole body (SPB), at the end of the meiotic spindles.
Sequence:
MGAGTLLNGLEKENFPNNIHSDLPAYPNMDSQEDGNTSKESKRNSPVKQKSQKDEEKSSKMGTASNIFHENKDIHERSEHTDDFNDGLKLAPDSSPSLKECQFKNWESFWCNTEGYKTKHMQPFHFTSGLEEIKEPVMELNISTSPYKGQRPNSAPTEYSAATTAFTKTQLEVSFLKTNLLTYIKKEIDICLSSVPFFDDAVQMQKKFLEYRDIDLDEEYELKILGELLNDLNFFHMQENSLLNRELAVRRFSNQPESQNLPSIRDFRNPLLPIDNRPSPPLGLKRNGKSFEETYDFTSNTSNFWGEKAELQNSITGGTPYFFHPNNIHQTKPFMSFENQNELLFQRKNSDYKQHFNSGRNIHNGVESKSYRGVGLNDSYQKGYAAMTKSFGNIDLNRMPRRSNEEMYSWSRN
The following text describes a protein:
Function:
Probable component of a transcriptional corepressor complex involved in branching control. Regulates cotyledon expansion and lateral root growth, but not germination or hypocotyl elongation. Promotes auxin transport and PIN1 accumulation in the stem and represses BRC1/TCP18 expression in axillary buds.
Subcellular Localization:
Nucleus.
Domain:
Contains 1 EAR motif required for the interaction with TPR2.
Sequence:
MPTAVNVAKQCLTAEASYALEEAVNVARRRGHSQTTSLHAISALLSLPTSVLRDACARVRNSAYSPRLQFKALDLCLSVSLDRIQSGHQLGSDDSPPVSNSLMAAIKRSQAHQRRLPENFRIYQEMSQSQNQNSLSCVKVELRQLILSILDDPVVSRVFGEAGFRSSELKLSIIRPVPHLLRYSSQQPLFLCNLTGNPEPNPVRWGFTVPSLNFNGDLDYRRISAVFTKDKGRNPLLVGVSAYGVLTSYLNSLEKNQTDGMILPTKLHGLTAVNIGSEISDQISVKFDKTYTDTRFHDLGKLAEQGSGPGLLLHYGDLRVFTNGEGNVPAANYIVNRISELLRRHGRRVWLIGATTSNEVYEKMMRRFPNVEKDWDLQLLTITSLKPCLPHNKSSLIGSFVPFGGFFSTTPSELKLPFSGFKTEITGPVSSISDQTQSTLPPWLQMTTRTDLNQKSSAKVVQTKEGLESVCGNKFTSSASASTCSAKSVTTDLNLRVSSVTTGSGLKKHLDSKDFSQPQSVSSYSFDNPRDLNAESFKIIYRRLTDMVSGQDEAARVISCALSQPPKSVTRRDVWLNLVGPDTVGKRRMSLVLAEIVYQSEHRFMAVDLGAAEQGMGGCDDPMRLRGKTMVDHIFEVMCRNPFCVVFLENIEKADEKLQMSLSKAIETGKFMDSHGREVGIGNTIFVMTSSSQGSATTTSYSEEKLLRVKGRQVEIRIETVSSLPMVRSVYGPTSVNKRKLMGLGNLQETKDTVESVKRLNRTTNGVLDLNLPAQETEIEEKYHCEENSNVWLMNLKNHKRLIEVPFKPFDFEGLAEKIKKSVKENFDKCVRSDCLLEVDPKIIERLLAAVYFSDSRKDIKELLENIMSPVFLRIKERYEITTSCVVKLVGRDLDIFLEDQMDLFFVKSQ
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDEVQMETARIQSPKSYLYTTLATTHLGEIASCIISILISNGRLTAREISNRTKIPTKNIKSALVSLIQLNCIYYWQEEKDRKFYYSLKETGLLLFVYSGDIINHIKRQYGEDEAEIIQNILIHGHVKIEDYLTQFNHDKSMKIDQENKFLKLFNDNWLIKLQDYHFHSLDDIWHKIFEECLKDTPRSSVTSEIKRVAEAQAKAKVKLNTLLESGTTGGGDIFTEVNGMKKLKPDLVVTFNLSRFQKHLRTNAFVNMVRSKIGVLTAIVYDAALRYIENKSPPMDYPLLDIPGLINDPKDVKEYILSIENKLVNEKKITFSARDIQRLLPKDIDFKNSVITPTFAKPKRPLENGSSPTLKKIKLEDGIASSTSTSTSTSSSTSSNGTSIDLNTLEQHLKLLLNGTNTAFVNEISPGNYTIPFSHLTNILKQNNFEALVKATLGDYAFRILRCVKSMKLCDEKSICNGALLKEKTVRSELYHLIKANIIEIQEVPRSADRAASKTFYLFRHKSNSNFNYLKNCLIYDMAEILNRIQDFKLEHKILLEKYKLVEGQEDQYLLDRELKLLNDLQLREIKNLVKFQRIKSLYSLYSLVD
The following text describes a protein:
Function:
Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process.
Miscellaneous:
MISCELLANEOUS: Does not bind zinc.
Sequence:
MNEFSILCRVLGSLYYRQPQDPLLVPLFTLIREGKLAANWPLEQDELLTRLQKSCDMTQVSADYNALFIGDECAVPPYRSAWVEGATEAEVRAFLSERGMPLADTPADHIGTLLLAASWLEDQSTEDESEALETLFSEYLLPWCGAFLGKVEAHATTPFWRTMAPLTRDAISAMWDELEEDSEE
The following text describes a protein:
Function:
Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The C-terminal RAB-binding domain (RBD) (1796-1945), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms).
Sequence:
MGENEDEKQTQAGQLFENFVQASTCKGTLQAFNILTRQLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGRSCMNTKCLIIGGGPCGLRTAIELAYLGAKVVVVEKRDTFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALILGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPVDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKKETGIDLENIVYYKDCTHYFVMTAKRQSLLDKGVIINDYTDTETLLRAENVNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTSMYASENAALVRERQSHLLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWDQGTSPLELLAERESLYRLLPQTTPENINKNFEQYTLDPATRYPNLNSNNIKPNQVKHLYITKELHQYPLERLGSVRRSVGLSRRESDVRPSKLLTWCQQQTEGYQHVNVTDLTTSWRSGLALCAIIHRFRPDLINFDSLNEDHAVENNQLAFDVAEREFGIAPVITGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYEENADLGLAKSSIPHHYLNLTFPRKRTPRVDSRTEENDMNKRRRKGFNNLHEPSAFSSQSLGSNQEGIKEGGNQNKVKSMASQLLAKFEESSRNPSILRQEHRVSGIGKPILRSSSDPPVNSRCPKPEEPTPSPSPPLKRQFPSVVVTGHVLRELKQVSAGGECPARPWRARAKSDLQLGGPENLASLPPTCPGALALSGVLRRLQQVEEKVLQKRAQNLANREFHKKNIKEKAAHLASMFGHGDFPQNKLLSKSLSHTHPPSSPSCLPSPDSAATSSPSTVDSVSPARKLTVGKVSSGIGAAAEVLVNLYLNDHRPKTQATSPDLESVRKTFPLNVGGSDTCYFCKKRVYVMERLSAEGRFFHRECFRCSVCATTLHLATYAFDVDEGKFFCKPHFIHCKTNSQQRKRRAELKQQKEEEGMWKEQEAARRDPPSESSCAAAAIATPEGSPPDEPTSPKKPKSIPEPEPGDVAGGAASPLPSEWTAVRISPGEDVVGQDVLAVRVLVTSDDSSSDAELDRGDSEASSVEPFDERPQQPELQLPPLLKPFTRHSSLREALPRAVSPHDLGEPEAEPALQRANSFQCPTPSEYQSGRRFQSNFMPVNSKMTVSPPKQACPPPPSPSPPSSSSIGDLNALDSPSLPQVTVSNTASQISRGHCSPSTPIFLRRAKAHGPPKDLPLRLPRGQVLERTEYCLVRPGGNGLQSSRPPSPTEMASDGCQEAVAPPRDIRSIHRGPHPVEGKDRCLPDHPLSPWAGEEPGEGSTRPRRVEDGGLELAEEKSGLKKLVLTPEQKTWLLDWNDSNLENLYLETGARLSQKSTRNGSGGHVLKPVHPLLLPLAEKETLPAQRQSQEKMGAPAERAPGERSMAPPKSPLRLIANAIRRSLEPLLPNSDSGRKAWAKPESKTLPTSPPHAYTCSFSFRKSSSSKDSDQPSPKRDVASKASAFFSLGSPTARTAQPSAPSPPAPALCTHSLPSRSSKVFPALVPPPCGKMEDVPTLLEKVSLQETVPDASRVPKKRTSLFSSFRLKDKSFESSLQESGPRKDSQDLFSSPKGKVQPMGNAQPPEKQGQPISSTCLGQRVHPVSPEKDASPTHVPIRAQGTGTVSSTSSSTTSSADEEFHPQPSSRSKERKALRRRRKLEKATKQLVKQEELKRLHKAQAIQRQLEEVEEQQRAFEIQGVRLEKALRGEAADSGTQDEAQLLQEWLKLVLEKNKLMRYESELLIM
The following text describes a protein:
Function:
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit.
Sequence:
MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVACAQNGLEVSLSSLNLAVPPPRFHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTVSISGSMWAIPSSAAKESYHSLPPVGISPTKAPLRQWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDKSSLQKNTIGSSPVADFSAIKELDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQDEVQRESLNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLAMKDLETDNNQSNWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRSSPEIAPSDVTDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVVAATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPFNPTISSSASSVVIPKPVLEETPSKSEDVPPALPPKTGTPTRPCPPPPGKRPINKLDSSDPFKLNDPFQPFPGNDSPKEKDPDMFCDPFTSSSTTANKEAEPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
The following text describes a protein:
Function:
Facilitates cholesterol efflux from membranes in a pH-dependent manner. Required for maintaining normal parasite plasma membrane lipid composition. Required for the proper functioning of digestive vacuole. Required for the viability of blood-stage parasites.
Miscellaneous:
MISCELLANEOUS: Mutations in the protein confer resistance to three diverse compounds: MMV009108, MMV028038 and MMV019662.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFVKNFIHKLKELKQKSLDKFANLLYDYGGYVYDRPCTFIICSLICCLLLTCGFYFKEHEKDIYKLYSISNSYAYETNETINDFFYKSRRCFILVESNVNLLKPKILRELQKFEEGTKDIEVDLSEINECKTNSELPPEQSHVAKELYKTLIQRSEENLKSGKINGSLFDYSDLDENGKSVLSLAGKENNDDTLIEGDNKNDEETSANNNNNEDDNNEDDNNEDDNNEDDNNENDNNNNNEDDNNNDDDDDEDNEEEDEEKQKSLREKLYRKIYEMLKKKKENIVLDENNPNVNFTDYKDDVFYPYQYIPPMLIKADRCKLQNVFGDKNLNIDLREASDGLKKQITYTLEDICEKKYGDCNFSSLFLYYEKGNGYIDYPIKVDNLDFYVNRRTYKEMMFKGILGNMVYEKSGSKYIIKSANAIMTVIPLLNSHTYEPYALAYEKKLIDYVRFYNLDDIIQDEETNDDNDPFIRFHVFTDRSLEDEVDRISKIDNLTRLLLLIGVLLIFMYALFNNVTSVLYRSKPLCAVMGIFCGFLGFLSGSGFLYFLGVKSVPPAETVPFLVIGVGVDDVFVILNSYSLLFMVKDNKKRIQMCLKDSALAITVTTLTNIIAFLISAISPFYSICAFSLFTASSLFFGYLMVLTFLLSFLCIEAKLEKKKRNIFTGTFHLFRSIFMKSSKKNKKENKENNIHDDGDNDNDEKKKDLSLEVKNNEDDYENISIYEWIHNLYLFEESINKKKKNAALVYASNNGMSSNLNNVNEDGFPNPSKIVSMEDVKKRNIKKDDAYINKEDEEGGGYYNKDDNKKKDILGKKQKKNNNNVTLVSKKGEDNELDVYYENLDEKTNDKYKMNNIKSSKLKYDNDKKDGAIINNRPSSDEEYKEEKDKNKINILNDVFNDITIKPNENILLDRGDVIKSSGYDSSYNDLQSSSLPNPSSNEVLNKTTMVYNETDLKDNKKEIKSSKKNVKDIKKSDMIHDDTYDIINSNNKNILLSSNEINNNSNNTNKFNNNSTELATKDTQQFINGHDKNIYLLSSHDNALFYKYIYEEPKGNIGKYFRSLVKNYYVPFLSSRFGKTIVYIMFTIIIAMSIYGCTLMKKGIKYDKAFPVDSYVRRFTTAKIKYFPDFGDFIEVYYFDKHFINKYRGLEKNTKEAASSFLYSDLTDRQIMNSPKINKNVHWENTNLQEELINMHNTLESQEFVTSVANGFTFFLNKNKSSLRKENPQEFYEIFANWLKKDFVGNLFKNDFVFLNGKLVAWRFHYFQKNVDDSEISSKWLKACKQITKLENHNVQMVCFHLSSIFNETDESIIEVTLINLGITILTILVVTAYIIKGFYSCVIIALIIFLIDLCIFGFMCLCGITMNIISMVILVLSVGFSIDHTSHIVQAFSHSMGRTRDEKMKESLHLMIGPVLHSGLSTWFVISTLFFSNKDFTVIFFQTLSLVLFFSITFSSMFLPVLLSSFGPLH
The following text describes a protein:
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Subcellular Localization:
Nucleus.
Sequence:
MPKRKAEKNAKGDTANMKNEPQRRFTMLSAEPSSPNIFNKARKAPSKKGKKVPKGKKGKANASKDGNNPAENGDAKTDQAQKAEGAGDAK
The following text describes a protein:
Function:
Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEKSIVQEARDIQLAMELITLGARLQMLESETQLSRGRLIKLYKELRGSPPPKGMLPFSTDWFMTWEQNVHASMFCNAWQFLLKTGLCNGVDAVIKAYRLYLEQCPQAEEGPLLALTRAWTLVRFVESGLLQLSSCNCCGGNFITHAHQPVGSFACSLCQPPSRAVKRRKLSQNPADIIPQLLDEQRVQAV
The following text describes a protein:
Function:
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. Is not able to produce D-ribose 1-phosphate from D-ribose and phosphate.
Sequence:
MLQSNEYFSGKVKSIGFSSSSTGRASVGVMVEGEYTFSTAEPEEMTVISGALNVLLPDATDWQVYEAGSVFNVPGHSEFHLQVAEPTSYLCRYL
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNLLFLFLLLLFFPSLFIAQTTTNSPAPAPTTLALDSTQLNLTHILSTHGCSAFALSLLSSTSAEKAFNDVVEGGFTVFCPNDDVWSEFSPKFKNLTPPAKTSLLEFHGVPIYMPLPVLKSNNGDTNTLATDGAARFDFTVQNEGEDVTVKTSITTAKVDGAGVFDEDPLVVYLIDKVLEPEELFTADVMAPPKGGSDVGAAPSSDSPAESPEESVADQNADGNSGVRVEGGDQFHFMAVALCAWMGFSLL
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
Sequence:
MSLQEKFDAAVEIIQKLPKTGPVATSNDQKLTFYSLFKQASIGDVNTDRPGIFSIIERKKWDSWKELEGVSQDEAKERYIKALNDMFDKIAEELDVAAWLEQIDPVIKTNLALIGK
The following text describes a protein:
Function:
Catalyzes the depolymerization of both polygalacturonate and pectins of various methyl esterification degree, with an endo mode of action. Shows the highest activity on 20 to 34% methylated pectin but retains 67%, 51%, 25%, and 1% of its maximum activity on polygalacturonate and 8.5%, 55 to 70%, and 90% methylated pectin, respectively.
Subcellular Localization:
Secreted.
Sequence:
MKKTVRSLCSTALALTLGFTLLSGPASVQAAGNADYNLAGFSQGNTGGGIISESNTSTYKKVYNATDLALALKKNSGVKVVEIMNDLDLGWNEIPSAAQTSPFAKHNDALTHPVLKQTGVSKITVDGFNGLTIFSANGSKIKHAAITVKRSSNVIIRNLEFDELWEWDESTKGDYDKNDWDYITLEDSSGVWIDHCTFNKAYDGLVDSKKGTSGVTISWSTFKGDDGSANSWVTRQINELEANKASYPMYNYLRSSAVGLSKQDVIAISGPQKKGHLVGATSLESANANLSITLHHNLYKDIQDRMPRLRGGNAHAYNIIMDAADARSAQSRITSAMATAIASKGYKFGITSNGAISTESGAVLVEKSVIKDVQXPCTQQSDRSDQRHVHR
The following text describes a protein:
Function:
Regulates membrane-cell wall junctions and localized cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLEHGKKPSAHPAPCTVQQVKDKLIGLRPVMLRASALLATTVAAAVMGLNRQSYTAVVAIVGTKPLTQTFTAQFKDTPAFVYFVIANAIASLYNLVVLAMRRLVQGRVQRLVLHMGDMVIMLLLATGAATAASMAELGKNGNLHAHWNPMCDKFGSFCNRGGLSLVSSFIGVTLMLALNLLSAAANTPRGIVAGQ
The following text describes a protein:
Function:
2-oxoglutarate-dependent dioxygenase essential for auxin catabolism and maintenance of auxin homeostasis in reproductive organs. Catalyzes the irreversible oxidation of indole-3-acetic acid (IAA) to the biologically inactive 2-oxoindole-3-acetic acid (OxIAA).
Sequence:
MSVDAKIEFPVIEFRSSDLERGTNGWYRLCKKVREACEIFGCFEVVYDTISTKVREEMFRLMKELVEVPVERKQKNTSPLPYHGWVGPCTQVSLLYEGFGLGDVSNYDSVKNFAQLMWPEGHPRFCDTIHTMGTQLEVLNKLILLMIIDSYGLSEDSLKINYTTSMRMMKYTTPPPGEYETGLFAHTDKPVSTIICEDQIPGLEIEVNDGQWIKLTNLSPSSFVFMVGDPLKAWSNGRLKSTNHRVMMSGDKDRFSIAAFIMPNEGTIIKTPKELIDEEHPQLFKDFDFMKFFFFAFSNPARHIDSGQLLYDFAALSPPVSNGHMDK
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MTPTGAAAKPSGSRAEPQEMASQPPPPPKPWETRRIPGAGTGPGPGPSFQSADLGPTLLTRSGQPTLTRVPPPILPRPSQQTGNSNLNTFRPAYTSFSSAYGAYGNSFYGSYNPYSYGYGGLGYNRFRMDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQQMMGLRRGSENEDLWAESEGTVACLGPEDRAANSAKSWPIFLFFAVILGGPYLIWKLLSTHSEEITATTNWASGEDDHVVARAEYDFAAVSEEEISFRAGDMLNLAPKEQQPKVRGWLLASIDGQTTGLVPANYVKILGKRRGRKTVELNKITEQQRAFTNPALINGTTAADTLEEQEAAFESVFVENNKVPVTSESTSKSGDKQDL
The following text describes a protein:
Function:
Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair.
Sequence:
MLQTPESRGLPVPQAEGEKDGGHDGETRAPTASQERPKEELGAGREEGAAEPALTRKGARALAAKALARRRAYRRLNRTVAELVQFLLVKDKKKSPITRSEMVKYVIGDLKILFPDIIARAAEHLRYVFGFELKQFDRKHHTYILINKLKPLEEEEEEDLGGDGPRLGLLMMILGLIYMRGNSAREAQVWEMLRRLGVQPSKYHFLFGYPKRLIMEDFVQQRYLSYRRVPHTNPPEYEFSWGPRSNLEISKMEVLGFVAKLHKKEPQHWPVQYREALADEADRARAKARAEASMRARASARAGIHLW
The following text describes a protein:
Function:
May be required for accurate chromosome segregation. Required for proper maturation of seed storage proteins. Forms a complex with MAG2, MIP2 and MIP3 on the endoplasmic reticulum that may be responsible for efficient transport of seed storage proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm. Chromosome, centromere. Chromosome, centromere, kinetochore. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=In prometaphase, associated with the kinetochore. At metaphase, mostly associated with the spindle. In early anaphase, found in the vicinity of the centromere. As anaphase progresses, dispersed in the cytoplasm.
Sequence:
MPEIDALFESINVRDLLAGHDLNDPTTPLSAPDLRLLINRLESHSLRIKSKVQSYLVAHHSDFSELFSLCQDTVSRTRLISDDVSDVLQLVSDRPIDVEIRSVVDEITEKTKEVKLKRESLDLVNAIVGICEALQETKEALKNGRFRFAAERIRELKVVLRIGEEEDGEPVAYALLRKEWSNCFDEIQEVLAKFMENAVRFELDSSRIRIKYQLSVGETAGIALSTVLEAMEVIGILDYGLAKAADSIFKHVITPAVTHASTFAAVEDLCKSAGEVTEATLRLEQSSDHKFEDVDGDAMYSGILKVVKFICSSLCFGNVTWIHSFGRLTWPRISELIISKFLSKVVPEDASKLADFQKIIERTSQFEAALKELNFVSSSDAESRLSKYAEDVEVHFASRKKIEILAKARNLLLQCNFTIPQDIAMRNAKHIVCLLFSSERCVVSEAASQLMNLVHKTLEDVCVSSARVASEFYNAARDSILLYEAVVPVKLEKQLDGLNEAAVLLHNDCLYLFEEILGLAFEYRASFPSSIKEYAVFADIAPRFKLMAEEVLQKQVHLVISSLREAIDSADGFQNTHQIKQFKSAEFSIDQVVFSLKNVHMIWEPVLRPKTYKQSMCAVLESVFRRIARDILLLDDMAADETFELQKLIYLMLKNLSSVLDSVRSADETSRPLDDIIPSLRKTRKLAELLDMPLMSITSAWESGELFRCNFTRTEVQDFIKAIFTDSPLRKECLWRIDEVNQ
The following text describes a protein:
Function:
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSYKPVAIPTYPKLGEKITQDTLYWKRYKTPVQIKEFGAVTKIHFSPIQPCSYAVTSSTRIHLYGQYSQEPMKTFSRFKDTAYCGTYRGDGKLLGAGCEDSVVQLFDISGKAALRQFSGHSKAVHFVDFTSDKYHIVSGSDDYTSKLWDIPNGIEITSYKEHTDYIRCGCTSPLNNDLFATGSYDHTIKVFDGRTDQSVMSMDHGQPVESVLLFPSGGLLVSAGGRYVKVWDILKGGQLLVSLRNHHKTVTCLSLSSSGQRLLSGSLDRHVKVYSTMNYKVVHSFDYAASILSLALAPDDQIIAVGMTNGVLNIKHRKPEEKKTLQSTAKRHPRYRVFVRGKDYMPKQDDIFVSKPVKAHLTKYDALLKGFHMSKALDAALQVRMKRPEVTVAVMNELKRRGTLKNALAGRDEKELSDLLIFLLKHLINPQFLPILLNVAEHIIDIYSPVVGQSSVIHKQFIRLQEVVEKEINYGEELLKILGMMDTLFATMTTKKESPWEEPKPILSLNSQ
The following text describes a protein:
Function:
Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs. Acts as a regulator of translation initiation and elongation (By similarity). Does not appear to possess DNA repair activity; no activity towards methylated DNA or etheno adducts. Exhibits a weak and unstable DNA lyase activity; this activity is probably not biologically significant and proceeds by a mechanism different from the classical dioxygenase reaction as it does not require 2-oxoglutarate or iron.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLAGNMEQANVFRLEEKRYKCRADTIPDMSEVLDPNDPQSFGFEALVEIKPRVFSFQKAPGLLILKNYVSSELQMQLLKSIMFTQIQDPENKTNLSPFYQLPLGNDSIWRRYYNGDGESIIDGLGETKPLTVDRLVHKKLRWVTLGEQYDWTTKEYPDPSKSPGFPKDLGDFVEKVVKESTDFLHWKAEAAIVNFYSPGDTLSAHIDESEEDLTLPLISLSMGLDCIYLIGTESRSEKPSALRLHSGDVVIMTGTSRKAFHAVPKIIPNSTPNYLLTGNKAWDGWISRKRVNFNVRQVRPSR
The following text describes a protein:
Function:
Plays a role in the inhibition of host innate immune response to promote latent infection. Mechanistically, suppresses viral DNA-triggered signaling by impairing DNA binding and oligomerization of CGAS. Also impairs the translocation of host STING1 from the endoplasmic reticulum to perinuclear punctate structures which is an essential step for its activation (By similarity). Regulates the function of host NEDD4 family ubiquitin E3 ligases through its PPxY motif and thereby prevents the excessive ubiquitination of gB and its degradation by inhibiting these E3 ligases.
Subcellular Localization:
Host membrane; Single-pass membrane protein. Host cytoplasm. Note=Accumulates in the perinuclear region of the host cytoplasm, with some dispersal into the cytoplasm in a fine-speckled pattern.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Contains one L domain: a PPXY motif which is involved in the interaction with Itch, a member of the Nedd4 family.
Sequence:
MEPTPMLRDRDHDDAPPTYEQAMGLCPTTVSTPPPPPPDCSPPPYRPPYCLVSSPSPRHTFDMDMMEMPATMHPTTGAYFDNGWKWTFALLVVAILGIIFLAVVFTVVINRDNSTATGTSSG
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEAASRGRRTQFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDHRLQQHRASGGDHALGSPSGEKSPAPEGPPAEEVQDPSMPVPAQPKAGGSGSYWPARHSGARAILLLLYREHLNPSGHSFLTKEELLQRCAQKAPRMAPGSTRPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGPTWLNVGIGPEEPPGEQPEVPGAASAELGASEGSVQQPPLELGPGEYRVLLCVDVGETKGVGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETRPSDPARPKELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLGRRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALFTRGLQRLYQGHTLRSRPWGTPGDPESGAGPSPNPLCSLLTFNDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDTCATPKEQEMLLSTIKCGRLQRNLGPTLSRTLSQLYCTYGPLT