lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAASLSDIQNEEFENSCLFLNDEDGSPILFYITPGPLKKRLKTLIEVRGGIVSSKITPGVDTILLQESSKDKPLLDGYTSSEYIKDCIHKNELLNIKPYQARATEKAGKSKLGAVSSSNSANIVKSTTGGRAKYTYEEDQAILDYVKQYACPGIPVGGNVLWKQMEREKVTGHSWQSMQCRYRKILRPVVSRVKKPKRLDLFVTKAKKPALSSSTRPKRLSARVCATQVKSYLVSSENSSDVDSGSEPQVKKVVGKRTNTIANSTDDEKMIRQTPRKNRPRFFDTTEHSKSDSDCYSSGNDSYNDGGHTNHTTSAQKRKIMQQTKYRKGLGDASPNKKKQASVDRDDDADQGAAPDAAAVDDEDDSLEDDGDEGGANVDHNEVINLKDETEFADTINMIFDKLQQIEDLRRKHNVSRVEVVNALRKASGSVSEASHALQSCKGASDPEEVLQSSEEKAGKTNEASHPLKRMIKTNEALQSPIKSKKDEVRSKVSTIEATQAPCGGGQSNKALRSREKAGKDKEATQSAKISESSNNAIKSPWKGRNDNEDIHSPCKGKIVSEDVKSPRKGRNVIKAFQSPKKGSKSSEESDNHKATNSPKKKSKTNVAILSPKKSGSTSHALRPSKRVRESYEAPQLRKRRHGNKTVLG
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MYLVDTVSADMEAAHLHPSEEPQFSASPKPQSCWSRRGGAEVHGGPSVPETTSPASKTLSSPTDPLAPASAGLPPTKTPLSWKSLSQVGAGLQNMGNTCYVNATLQCLTYTEPLASYMLSQQHGTTCRRQTSCMLCTLQAHLTRVLCHPGRVLRPLPLLLAAFHRHKQEDAHEYLMFILDAMQQACLPEDKLSDPECPQDSTLIQQLFGGYWRSQIQCLHCQGISSTLEPYLDISLDIGDAHSVSQALEQLVKPELLEGENAYHCSKCLEKVPASKVLTLHTSPKVLMLVLRRFSDLTGNKMTKEVRYPERLDLQHYLSEQRAGPLVYVLYAVLVHAGRSCHSGHYFSFVKAGNGQWYKMDDAKVSACDVTCALHQPAYVLFYMQKTDLERDLGRESVKEGGLASLEADPTVVGEASGEPAMDPSVNLPELEERGEETSRQQMTLDQWRCLQECNRPKPELNVRRREIALPANAVILHHSKYRPEMPKNHPQQTVDLLTTAAGMIPPQVAGDVAKLPHVPGRARPTKRTSKKGQRSGEAVQGCVS
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MMGNEACKMIFASTNGHIKETKFEKQSDNVWNEGNTKKLLSPETVVVRSVLGDKIDVENKLRDEAKKCKWLVLWFDNDPEGEYIAYEVHEICVQQNYEIIVKRARFSSLNPTAVDATIKTSLDDLNPCLLDAVAYRKEVDFKTGRVWTRFQSFLARKQIPNATNLTLSYGLCQSALLGIVVERFNQVAKPKAQKYNISFNDRGYGPKVTFTSPVWYDAKSKASKKLQSCSDEKATIVEVFVEITNKFNKFHSPPVPLTTMELEKLAAKYFKMTPKQTMNTAEDLYTQGFINYPRTETDGFSMN
The following text describes a protein:
Function:
Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation.
Subcellular Localization:
Cell membrane. Secreted, extracellular space, apoplast. Note=The precursor of SCOOP5, PROSCOOP5, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP5 in the apoplasm.
Sequence:
MATKTSNFVSLRVSLFILLLFISSQVAIADAKHLQQLRRKLQIVRRSRSQRGRQYNPPTLRVPPPPPPPLPQMPSAATPPPMPQLSPLQPKMHVSSLQPQMLYPPPSLPYASSPTST
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Sequence:
MEGIDPDTLLEWLQAGFGDERDLQLMALEQLCMLLLMSDNIDRCFESCPPRSFLPALCKIFLDETAPDNVLEVTARAITYYLDVSNECTRRITQVDGAVKAICNRLSVADLSDRASKDLAEQCVKLLEHVCQRETLAVFHAGGLNAMLNLVTKHSANTHKDTQHSAMSVVTRLCGKMEPTDESIPNHTQALGELLGHDDPKVAECALRCFAALTDRFMRKQMDPVALSSHSHLVNKLLLKLEGTNASTPANLTSIVLSLLSNLCRGSSVITEEVLTSDRLITGISSVLSAKEERAVTDGLRLADLLILLLCEGRQALPMSAISSVPDSSSTSSSSSEKTHRHLIDAIRQKDTGALIEAIETGPVDVNYTDEVGQTLLNWAAAFGTAEMVVYLCEKGADVNKGQKSSSLHYAASFGRPDVTKMLLARGGNPDLRDEDGKTALDKARERNEEDYIAVAAILETPSVYMSAGGTGDASEAKKETEGKNESGGGDSESISMDKTKVVRLLKQLIPVFCEIHQKTTSPTSKRSSLSLLRRAVQHWTKIEMQLEEEGVDLNTLKFEEEIETRLSDAILDLIVNVLEREEDYDAREQSLMVIGALLTKETSRLAWIDELIRLGLFEKVEAMITELESPKEEKDDCPSTLPPAPPVSALSIEERSERSVSTTPSLALSDTTEGSIQTAEERERDRASMLKVGMGMEEDAGTPPPTLEGVVPPSTAINTVTPIGNPPESGDASVELAAATAYRWKEWRIVKTTESFFVWADPLSIEFPASGPIAIRSLCDNQLRSFSSTGVPEVCQAKDAFLTRFRRAIGSVPTGIRHAKSICVVPTASKKVFVPHKMPGWEIFSPKASELHFKSLKWPNLQIRLNDDQAGFTLDFGHGKTTINSECLLEAEFHTGWTTYSNNARCNRLRSGMQAKRVQDLALDIWNKYLKEAKTRPREALVQLQAASHVVLEAVREATRDLGSMTPQPRIEKVKELVSALELIREAITDERRLSTFEVCSSGLVPALTNLLTFVAEQPKAYPSLIFKETFRSRDTVTAMAHRMVRVFEANEKFPMYLYDNPGGSAIGLQLLSKKLKLKLSLPKGVDGDESTLLNRSGRNIRCEPLCSVGQLKHFLERMVIKQWFDRPRPTYKSMKLIKEASEKGEPLTFKYISDFDENGIIYWLGTNAKSESEWTNPASVGVVVATSSDAPRQPFGRPEDILSRDPNALNCHTGDDKNGFFSIDMGAVIKVSNYTLRHSRGYSRSALRNWLFQGSNDNKTWDVLSYHKNDTALTEPGSTATFPIDAGKGAYRYFRISQNGENSSGSTYYLSLSGFEMYGTVLEAVEKEIRCDNEKGEKKSRLPISSTPLSSPFPPLGSLGHPLHASAPSKLPHPDKSSKKNRSSGTPSGRQSRVVGRNAEEKEYIESLVAAGMNNRFRVWSMDKCMEVARSMQPSVASGSNKVLASRVRLSSRRARQSVDITRSRVTRGPDWQWNEQDGGEGGEGNVMGPPEAGWIDIQWINNGCCNSYRWGADGKFDLTAIDASNPPAPSPLVDSSPFANLPGLSSLSNSLGLRNKRGSAAGVVPCSASSSSSTTSTIGKKSMSTTNLVEERVPSVSVAATGQAASAESLQHQTPSLENILANYTGGRSMGMEALFDETREAYMEGEDSIELSGSAEVVEDEIEEAKEASEGDNTGNNKNLSASTPNLKNALLKELDDGEDEEDEDEEEEGTEDGEEGEHDESRSDHNKSSTDTLAALLDSFGGERKFLEKLRDFAADYSMDSLMNESGQSSSSASTAGRHPSTLPSTSSTPSVPSSTPSFTATSAGKKAVAAVKSKASSYADAMKSLMQHMLEPTNSVDGEAEDFEDEEMYDDVDGTEEDLEEEFSMTGGLPVESLASLLKGTADGSALRVNFKTLSQLMMGGRNSDRINKDSGKAERGVNAFHLRHFDDEFILKCTFNALIPAFDPRPGRTNAKQTVDIELPSAHGSAASTSTAQPQPVAIHAPTMQPLAALKSDVRLRLFMVGPNQLGVENVTVEMEEDDECIFKYIQSIVNHLGWSQSDGCRRIWDSSWNIFYEDASQPSKMTASPLNPVDVIPANVQEVLRVLLLLKRVGGLLPECDITPDVFISEKITHKLKQELSDPLVVSAGILPSWCAKLVFDYPCLFSIETRQLYLQATSFGVSRSIVWLQSRRDAAIERNRGGSTNAALASARRDDQYEFRLGRIKHERVKISRNEDELLEQAIRLLRFHADRKAVLEIEYTGEEGTGLGPTLEFYALVAAELQKKCLAIWMCDDADESQLKMEESELDLGEGKKPPGYYVRRSSGLFPAPLPPHSKDSKRATELFKVLGIFLAKVLQDGRLVDLPLARSFLKLVTHPAVSHDKPMKTEGVLDLDDFEEVHPVKGLFLKELTALVARKRGIEADQSLKQETKRRRLEELTMSINGTRCSIDQLGLNFTVNPPSTVFTYEEMELIEGGADIDVTIENVDLYVDKCREFYLNSGIRPQVIAFRQGFDRVFPLSSLNAFSPEEVQRLISGEQTPEWTREDIINYTEPKLGYTRESPVFLRFVDVLVEMSGADRKRFLQFATGCSNLPPGGLANLHPRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSEIMRERLLTACNEKGFHLN
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Preautophagosomal structure membrane; Multi-pass membrane protein.
Sequence:
MFTVAEDNEEDDDATSATLADFGLHQLADDDQYHHRSSHRPQHHMNGGYNAPLLQNEFGFEDDDTTIHHHHQSQQQQQQYQYSHHDHMGTSINTNNTNEQHNDNNNTDNGNIGFIILKRLKLLPKNEGWALVSDLDLFFSSLYNYYYMRGLGSIIGKGVVELISLFFTLWLSLVLFAYIDWSGLSSCNDEETCKESFVEGYLIENPFMEGRHSFLRNAWIVVYCMLFSSYGVFCLIQFGHSVMASLESKMFLEEVLGVSDRDLEVGRVEWGEIVERMSDAQRDGRCRVAILPMDKQKHVDNNNNNNNNSTIIEDEGPTGHLVVSQRIMRRENFMIAFFNKGLLDLTLPQFPPWAWPLSAWTRRPREEKQVFFSKSIEASIYFCVLNYMYNNSKKIRPAFYGDPSSLRRRFVLCGVAHAVFMPFLLFFVTLHFFMLNIYDWQSTKEYLGPREWSSVARWTFREFNELPHLFERRMEPSYKSASAYLDLFGKPSPLSIAIGRLLVFVSGSLGTLLLAFAAINDAILLHVKIGQWNLLWYAGIMGACFSVGKSLLPKTTSPYYGHARRNLVLDMNSELEKVATHTHYFPDAWRGKGCDDRTKKSFSSMFQFKAQHFAMEVVSIIVAPLVLCFSLPRCADDICRFVRDSKVEVPSAGDVIGYCTFDFDTFEDDNWRGKRGTPIVNKDTTNTSSANGRPKTRHGKMEKSFFSFKSAYPNWMLPPSGKNLVDLVESYRRKQEMALAYEQRLHIDAAAAQLETLRRLEMERTKNTSNGLVGYVDGRHYVKTTSSAGPDSGGGGMLKSVETDASQHTDGGLSNFGSFDSDGLHHPHVHFEESAHSFAPPTNAFAHSSSVYGEDGNTTTQRVPSLSRQQLGNTNASVLHYADAGLSTELRGLLNRSSIVDPSASNAMYASEQSFTGSLVPMDDAATSILDLRSDLQYRWLDRYHSEMGSQRQHSTN
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MEKFSMAATMFCAVVLAALAAAGGGEAAVVEHTFVVHEMNQTHLCNTTKIYVVNGQLPGPTIDVTDDDTVVVHVVNRLPHGLTIHWHGVRQMRSCWSDGAGFVTECPIPPGGEHMYSFNVTGQVGTLWWHAHVTCLRATVAGAFIIRPKGGRYPFPTPAKDVPIIIGEWWELDLVELDRRMHDGNFDDNPLSATINGKLGDLSNCSGKPEESFVLDVVRGDTYLLRIVNMALFSEYYFKVAGHTFMVVGADGYYLTPYKTDMVTVAPGEAIDVLMAANAPPAHYHMVALANQPPEPDPQIPGQHNTMPSYYFHSNLTGLAHPDRHRVPMHVDERLFFTLGLGSICRGTNKTCERGRSPETIVVATMNNVSFRHPTNASLLERYYDGRTSGLYTEDLPDHPPHPYNYTDRSLIPPGPLEKALEPTFKATKLRRFRYNTSVEIIFQGTALLQSDSNPMHLHGYDFFVLATGLGNYNPKTDPKKFNYHNPPLRNTVQVPRTGWAAVRFVTDNPGMWYLHCHFEFHIIMGMATAFIVENGPTPETSLPPPPPEFKRCGANGFTQP
The following text describes a protein:
Function:
Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Mitochondrion.
Sequence:
MDNLNDALEKLKITGTECTSDKLDGCLDCLLQALGHNNTESSEKIQQSGILQLFASILNSESSCSSKVAHIVAEIAKNELMRIPCVEAGLIPPLVQLLHSKDQEVLLQTGRALGNICYDNHEGRRAVDQEGGAQIVVDHLRSMCTLTDPSSEKLMTVFCGMLMNYSSENDSLQTQLIQMGVIPILVDLLGVHSQNTSLTEMCLVAFGNLAELESSKEQFASTNVAEEIVKLFKKQTEHEKREIIFEVLAPLAENDAIKMQLVEAGLVECLLDVVQQTVNSEKDDDIAELKTSSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWLPSNNHQLQLAGALAIANFARNDGNCIHMVDSGIVQKLLDLLDRHVEDGNVTVQHAALSALRNLAIPVVNKAKMLSAGVAEEVLKFLRSEMPPVQFKLLGTLRMLIDAQAEAADQLGKNEKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIRTIVQSGGVKHLVTMATSEHVIMQNEALVALGLIAALELQAAEHDLESARLVEVLHRLLSDERSAPEIKYNSMVLICAVMGSEPLHKEVQKLAFLDVVSKLRSHENKTVAQQASLTEQKLTVQS
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MEYGKLQPTESARYTEQLPQKQIQTRKHILVRDARVTFLVLLFLLIVASLLTIMIVIVMKHKHYFKKNTTSTSSSSNNSAGVGVPPAAASVSLTRICEVTRYPATCVTSLGEYMNTQMIGDDVETRPGYVHVSLDVTLERLRKGLDYLMMEKKRFDEIKDSFEWSAHDDCVELMEDSVDLLTRSRPLIMMLVSLSNDDQKNNQSQTSIMDLMTWMATICTNQDTCTEGFEEAGGALKHETAQILQDLWQIVSNHLDLSSTVLSNDVVSGRRLMGLEPTNMDHKYPKWISRKHREMLATPINMIQPNITVSQHGIGPNVTVRSIWEAIEMAPKNSSTPFIIHVKAGRYQESNLIVSKRKTNLWFIGDGKGMTIITGSKSVKANNVTTLKTATFGVTGAGFLARGITFESTAGPQNHQAVALLVKSEQSVFYECEIKGYQDTLYVHSNRQFYRNCDIYGTVDFIFGKAQAVLQNCTIYSRKPMEHQKNTITAHKQPCSNMCTGISIHECQIRAAPDLELVKSNYSTYLGRPWSEWATTVYMVSYIGDHVDSQGWIPWNATSSLDSVFYGEFMNYGPGANTSQRMISSGVHVNLSVAEAGRFTVDQFVGGSSWIGQTQVPFEAGLWEMAQPPETVP
The following text describes a protein:
Function:
Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Domain:
Has 2 AAA ATPase type nucleotide-binding domains (NBDs) per monomer. NBD1 is primarily responsible for ATP hydrolysis. NBD2 is crucial for oligomerization (By similarity).
Sequence:
MNILPKSIPIRIQSLRRYQGSLKTSLRALSTRPIFEKRLLAETPFSIRPSNASVLIAKRSPKFGWKQVRFYAANPNGGNFRMDLGGGRKQGAALEEYGTDLTALAKQGKLDPVIGREEEIQRTIQILSRRTKNNPALVGPAGVGKTAIMEGLASRIIRGEVPESMKDKRVIVLDLGALISGAKFRGDFEERLKSVLSDLEGAEGKVILFVDEMHLLLGFGKAEGSIDASNLLKPALARGKLHCCGATTLEEYRKYIEKDAALARRFQAVMVNEPSVADTISILRGLKERYEVHHGVRITDDALVTAATYSARYITDRFLPDKAIDLVDEACSSLRLQQESKPDELRRLDRQIMTIQIELESLRKETDTTSVERREKLESKLTDLKEEQDKLSAAWEEERKLLDSIKKAKTELEQARIELERTQREGNYARASELQYAIIPELERSVPKEEKTLEEKKPSMVHDSVTSDDIAVVVSRATGIPTTNLMRGERDKLLNMEQTIGKKIIGQDEALKAIADAVRLSRAGLQNTNRPLASFLFLGPTGVGKTALTKALAEFLFDTDKAMIRFDMSEFQEKHTIARLIGSPPGYIGYEESGELTEAVRRKPYAVLLFDELEKAHHDITNLLLQVLDEGFLTDSQGRKVDFRSTLIVMTSNLGSDILVADPSTTVTPKSRDAVMDVVQKYYPPEFLNRIDDQIVFNKLSEKNLEDIVNVRLDEVQQRLNDRRIILTVTEAARKWLAEKGYSPAYGARPLNRLIQKRILNTMAMKIIQGEIKSDENVVIDVLDGELEFKANKLEPQSTSHED
The following text describes a protein:
Function:
Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.
Sequence:
MNHDIPALALGPQGEVMAHAIDACVHCGFCLPACPTYALLGDEMDSPRGRIVLMKEVLEGSLELEDAAPHLDRCLGCQGCVTACPSGVPYGELITSFRGWSEPQRERTPLDRAKRYAILKALPAPKLFSVAARVGQFAKPLAPALPAALKAPLDLLPEHVPAMQPQPRVTPARGQRRGRVAFLAGCAQQALTPNFNAATLRVLSRNGIEVVIPEGQGCCGAAALHTGARDEALRLVRANLAAFNPDEYDAILSNAAGCGAGLKEYPVVLHGLPDEAQAQAFAAKVQDISEYLAGLLRDGELAPLMPTREPVKVAYHDACHLAHAQGVRSAPRELLRAIPGVTLTEIPEGDLCCGSAGTYNLEQPELANQLGQRKAKNILGTQPDLIASGNIGCHTQIQSHVRRQGSPVPVMHTVEVLDLAYRGEL
The following text describes a protein:
Function:
Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MAAAVAGPLAAGGEEAAASVSVPGSPGLPGSRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSSLPPYICQLPLRVLIISNNKLGALPPDISTLGSLRQLDVSSNELQSLPVELCSLRSLRDLNVRRNQLSTLPDELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQICLKGKLHIFKYLTMEAGRRGAALGDLVPSRPPSFSPCPAEDLFPGRRYDGGLDSGFHSVDSGSKRWSGNESTDDFSELSFRISELAREPRGPRQPREDGSGDGDLEQIDFIDSHVPGDDEQSAAEVRTQEPLPSELSLAAGDMERPSSSRREEPAGEERRRPDTLHLWQERERRLQQQSGAWGPSKKDSGPPKSSAAQLGVSGEQGAPTLPSTSQDPLPVSGPVTAPVPRPLGSIQRPNSFLFRSSSQSGSSPSSPESVLRPRPFPQILEEKELISQLRQILESRLQQPLPEDLAEALANGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKSRKNVENFLEACRKMGVPEADLCSPSDLLRGTAQGLQTILEAVILAGGKAPVPVQPPSGLGGFLLFYVVSMLLLYVVYTRLLGS
The following text describes a protein:
Function:
May play a role in intracellular membrane fusion.
Subcellular Localization:
Endomembrane system. Cytoplasm, perinuclear region. Note=Appears to be exclusively membrane-bound.
Sequence:
MSSDVRVHTWPCSYYLDLEKQWLPGKLTLTPRSLKFSVDKAEEVLVGLPLSSITEIRKETSLFIFSAITVLEKGQAKHWFSSLRPSRNVVFNIIEHFWRELLLSQPGTAANPTSPMTRGQELMGLMASSQRRMEDTAKVLHHQGEQLDSVMRGLEKMESDLDVADRLLTELETPSWWPFSAKFWKTPVEAKPRDSVSVAPCEPFGKEGVVIRVPAVVSQRTESHSKPGKLTVLVSGLEIHDSSSLLLHRFEKEDVDDIKVHSPYEVSIRQRFIGKPDVAYRLISAKMPEVIPILEVQFSKKIELLEDALVLRSRGRASPAEGGCSIRHAASRLMGCTTHQELPTGGQEGQQSQLQKDWPLLSEGEAQELTQILSKLKGLALDTEAELERQDAALDGITVAVDRATLTVDKHNRRMRKLL
The following text describes a protein:
Function:
Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carbon dioxide avoidance.
Subcellular Localization:
Nucleus.
Sequence:
MYASKRRQRNFKRVRDPPKQLTNTNPSKRHRERLNGELETVAMLLPYDSSTISRLDKLSVLRLAVSFLQCKAHFQACLHNSQFLSAGFPMSTHSYSYQPHPPIPFSNKVPTIFDLRIGTPMLDPEESNFEEISLKSLGGFILVLNDNGEIYYASENVENYLGFHQSDVLHQPVYDLIHSEDRDDIRQQLDSNFHIPTSSASNQFDVFAPQNSKYLERNVNARFRCLLDNTCGFLRIDMRGKLMSLHGLPSSYVMGRTASGPVLGMICVCTPFVPPSTSDLASEDMILKTKHQLDGALVSMDQKVYEMLEIDETDLPMPLYNLVHVEDAVCMAEAHKEAIKNGSSGLLVYRLVSTKTRRTYFVQSSCRMFYKNSKPESIGLTHRLLNEVEGTMLLEKRSTLKAKLLSFDDSFLQSPRNLQSTAALPLPSVLKDDQDCLEPSTSNSLFPSVPVPTPTTTKANRRRKENSHEIVPTIPSIPIPTHFDMQMFDPSWNHGVHPPAWPHDVYHLTQYPPTYPHPPGTVGYPDVQIAPVDYPGWHPNDIHMTQLPHGFTPDAQKLVPPHPQMSHFTEYPTPSTHHDLHHHPLKQDNFHLISEVTNLLGT
The following text describes a protein:
Function:
Involved in spore core dehydration; might be involved in the transport of something into or out of the forespore or could be required for some modification of the cortex peptidoglycan structure.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEIAFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAALGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLADLIGVVASIIIVTLLFGSA
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLVSSSKITRAREMVTKTEEKQLNQLEIQVDNGGGGTWEYLCLVRNLKVRRSEKVLKHGSSILNDQKKRSALGPDEWTLNEQVAIAAMDCQCLGVAQSCIKALQTKFPGSKRVGRLEALLLEAKGLWGEAEEAYASLLEDNPLDQAIHKRRVAISKALGKPSIAIELLNKYLELFMADHDAWRELAELYLSLQMYKQAAFCYEELILSQPTVPLYHLAYAEVLYTIGGVENIISARKYYAATVDLTGGKNTRALLGICLCASAIAQLSKGRNKEDKDATAAPELHSLAAAAVEKEYKQKAPDKLQLISSALRILKT
The following text describes a protein:
Function:
Required for male fertility and normal male germ cell differentiation. Plays a role in spermatogenesis. Binds to RNA but not to DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSGNNDWFQSTRVPSFAQMLKKNLPVQPSSTTVNPPPGYSSSENYSVSNLASKVTQVTGNFPEPLLSKVVLPNPNAVLPPKKIPKEFIMKYKRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDDPEPRNIEPSGPPLIPAEPIISAESNYVSKVHYEGRHIQHAKISVAIKDTFNRLTAKHSEYLNCSSSLAAFVIERAGQHEVVAVGTGEYNYSQCIKPDGRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMMEKSIFCTEPASNLLTLKQNINIYLYLNQLPKGSAQIKSQLRLNPRSLSAFEANEELSLHVAVEGKIYLTIYCPAEVVNRVSSMSSSDKLTRWEVLGVQGALLSHFIQPIYISSILVGDGSCSDTRGLEIAIKQRVDDALTSKLPMFYLVNRPNISLVPSVYPLLTDLEYKSLSLNWAQGDISLEIVDGINGKITESSPFKSGISMASRLCKAAMLSRFNLLAKEAKREDLLEASTYHAAKCMSGSYQEAKTLLKSYLQQHGYGSWIVKSSCIEQFSM
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
Subcellular Localization:
Nucleus speckle.
Sequence:
MATLDAEANEEQFGNDQPKSMSGPIIGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNELGNPKFNFLNGGDPYHAYYRHKVNEFREGNDAGITALASMKQLAVTSAAQQRQQELLKQVVEQQFVPKEPPPEFEFIADPPSISALDLDIVKLTAQFVARNGRQFLTNLMSREQRNFQFDFLRPQHSLFQYFTKLLEQYTKVLIPPKDLLGKLRSESAPGRSSMNQVLEQVKYRANWQRHQEAQRRREEEKIERERVAYAQIDWHDFVVVETVDYQPFESGNFPPPTNPDEVGARVLMEERLMDEEGDTEMQIESDDEGDSQANNLLDSGLKLSQMENRVGIQMKNVSSYGQPTGPKRDNTQVQDMDEASSDEDTPTTKLQPSVAPMLPPTHDKVVVKKYDPKATQPKQAPMPTDEYLISPITGEKIPASKVSEHMRIGLLDPRWVEQRDKHTVEKINQDNVFAAGTAIEASLKQLAERRTDIFGVGDEETVIGKKLGEEETKKDDRVTWDGHTSSVEAATRAARANITLEEQIHQIHKVKGLLPDEEKEKIGPKPVGNKATLSAPPQPSTKSQHSHSSQSQHHQGGGGGHHGHHNPHHHHPPHQQAPPHQSHHHHPPQQPQPVMQLMQLRPTMMQPPFGAGGGGYMNMQPGGIPQQIAPAPPVDIMEEEPPSKKIRSEDNLIPEADFIATHKSPVTIQVLVPNSDKSEWKLNGQMIAVTMALSEPIANLKTKLQDETGMPPAKQKIFYEGMFFKDSNTMAFYNLVNGTTVHLQVKERGGRKK
The following text describes a protein:
Function:
Component of the Set1C/COMPASS complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face. SPP1/CPS40 can recognize methylated histone lysine residue H3K4me3 or unmethylated H3K4. Stimulates the RNA binding activity of SET1.
Miscellaneous:
MISCELLANEOUS: Present with 1680 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The PHD finger is responsible for methylated H3K4 recognition; The C3H-type zinc finger is distinctly different from CCCH-type zinc fingers in both the amino acid sequence and the overall structure. Most CCCH motifs contain the C-X(7-9)-C-X(4-6)-C-X(3-4)-H sequence, while SPP11 employs the C-X(4)-C-X(10)-C-X(3)-H sequence to coordinate a zinc ion. The C3H-type zinc finger is necessary to ensure the overall structural stability.
Sequence:
MSLPQWCPPHSTLKRNPTTGEDVYCICKRPDYGELMVGCDGCDDWFHFTCLHIPEQFKDLVFSFYCPYCQAGITGKNKDAIINGEGSLPKTLWKRKCRISDCYKPCLQDSKYCSEEHGREFVNDIWSRLKTDEDRAVVKKMVEQTGHIDKFKKFGQLDFIDNNIVVKTDDEKEIFDQIVVRDMTLKTLEDDLQEVQEISLPLFKKKLELLEVYLGWLDNVYTEMRKLDDDAASHVECGKEDSKGTKRKKKKNSSRSRARKNICGYCSTYERIPCSVEEFVRDFGSNEEATKIHEVCTKWKCNRHLDWVSTNQEQYLQQIDSLESMQERLQHLIQARKKQLNIQYYEEILRRGL
The following text describes a protein:
Function:
Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells.
Sequence:
MNQVFFSKIRSLVSADRHRFKSKEMDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEIVSGSHMVEEFVLTFRSIELGPLTKDQANSLSFEIFEHAKEPILNFASSSNSIQIVPINNDNSESNNNNNNNNNNNNNNNNQQQQLYKIIILIQKKVQNDVLIRVYRGDTGKGKGKMKKQIFHLIFNIAFVNLDQCLFGMNEFDHFKSSKKYDPNLQMECRFQNNCTGAPDHSFKIWNIMALQYQRTKSSLNNSITDIKSINEINSTNNNNILASSAPTPLTTTTTTTTTTTTTSLPSSEHSTPQILISSSDANLDLKNCNINCDSSSGGGSNSSRNSNSNSRGGSSNSSSNRSSTSSRSSITTDSIKPSCSSDSICNNSSICNNSCNNNNNNNNNNNNNNNNNNNNNNNNNNNKNSNNNNNESSSNSNDDSDSEASIRKRKNTLWSSGSSIKLKPSPNLSRLSLFNGHRQSFTKKINPNNNEENVDQKTLPILKKETNDPSESDIKNVEIIQD
The following text describes a protein:
Function:
Catalyzes the deamination of L-threo-3-hydroxyaspartate to oxaloacetate and ammonia. Shows a high specificity towards L-threo-3-hydroxyaspartate as other 3-hydroxyaminoacids, i.e. D,L-erythro- and D-threo-3-hydroxyaspartate, D-threonine, L-threonine, D,L-allothreonine, D-serine, and L-serine, are not substrates for this enzyme. Exhibits no detectable serine racemase activity. Is responsible for the 3-hydroxyaspartate resistance of S.cerevisiae, and thus may be involved in the detoxification of naturally occurring 3-hydroxyaspartate.
Sequence:
MIVPTYGDVLDASNRIKEYVNKTPVLTSRMLNDRLGAQIYFKGENFQRVGAFKFRGAMNAVSKLSDEKRSKGVIAFSSGNHAQAIALSAKLLNVPATIVMPEDAPALKVAATAGYGAHIIRYNRYTEDREQIGRQLAAEHGFALIPPYDHPDVIAGQGTSAKELLEEVGQLDALFVPLGGGGLLSGSALAARSLSPGCKIFGVEPEAGNDGQQSFRSGSIVHINTPKTIADGAQTQHLGEYTFAIIRENVDDILTVSDQELVKCMHFLAERMKVVVEPTACLGFAGALLKKEELVGKKVGIILSGGNVDMKRYATLISGKEDGPTI
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MEQVAQSRPSRQAVASDIDAAAYANNHADTSSSVPMKQNGRPGSRELNKRSLDYVLRSGLAGGLAGCAAKTVVAPLDRVKILFQASNPHFAKYTGSWFGLASAVRDIHRHEGVRGLFKGHSATLLRIFPYAAIKFLAYEQIRAVIIPSRDKETPFRRLISGSLAGVTSVFFTYPLELIRVRLAFETKKSARSSLAGTFRQIYNEQASVPSAAAKGTAGSAVTTAENVSSAMNKVVPRYGLSNFYRGFTPTLLGMLPYAGVSFLTHDTVGDWLRSPLLARYTIIPASDQSSHSQSQKGSRRPQLTAAAELFSGAVAGLVSQTCSYPLEVVRRRMQVGGAVGDGRRLGVVETAAKIWLEKGLRGFFVGLTIGYIKVLPMSATAFFTYERLKWSLGI