lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
Subcellular Localization:
Cytoplasm.
Sequence:
MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKILNLRVFEDEGGRHWAKSVMDKQYEVLCVSQFTLQCVLKGNKPDFHLAMPSEQAEGFYNSFLEQLRKAYRPELIKDGKFGAYMQVHIQNDGPVTIELESPAPGAATSDPKQLSKLEKQQQRKEKTRAKGPSESSKERSTPRKEDRSASSGAEGDVSSEREP
The following text describes a protein:
Function:
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.
Sequence:
MASTEGANNMPKQVEVRMHDSHLSSDEPKHRNLGMRMCDKLGKNLLLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEETKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRMQEDIEMTKTQSIYDDKNHRESNSNQCVYAAHNSVVIDECKVTLAANGKSADCSVEEEPWKREK
The following text describes a protein:
Function:
Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MAVPVPLGRFGSFCLRLLRLLALLELLVHPVLGRVHHLALKDDVRHKVHLNTFGFFKDGYMVVNVSSLSVNEPEGATDKDAEIGFSLDRTKNDGFSSYLDEDVNYCILKKKSMSSVTLVILDISGSIVKVRSPPEAGKQLPEIVFSKDEKILSQSQEPAVSSNPKDSEARRTLDGFKAGRSTVDSKAITERSFSIHKNDGVVSFQFFFNISTDDQEGLYSLYFHKCSGNNVKPGEQASFSLNIAITEKNPNSYLSAGEIPLPKLYVSMALFFFLSGTIWIHILRKRRNDVFKIHWLMAALPFTKSLSLVFHAIDYHYISSQGFPIEGWAVVYYITHLLKGALLFITIALIGTGWAFIKHILSDKDKKIFMIVIPLQVLANVAYIIIESTEEGTTEYGLWKDSLFLVDLLCCGAILFPVVWSIRHLQEASATDGKAAINLAKLRLFRHYYVLIVCYIYFTRIIAFLLKFAVPFQWKWLYQLLDETATLVFFVLTGYKFRPASDNPYLQLSQEDDDLEMESVVTTSGVMENMKKVKKVSNGAVEPQGSWEGTA
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATEQPKSATEDVKIDLFEDDDEFEEFEIDEEWEDKEEGKEITQQWEDDWDDDDVTDDFSLQLRRELENNTENNN
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MTWLEVLPVFGIITGGLVVIGVGLDATHRLFHYGKPHRYNLDRVDYSIGARDEQILRNRAIKESPRRTRNEIKRINNLVKE
The following text describes a protein:
Function:
Blocks voltage-gated potassium channels. At 2 uM, blocks rat Kv1.1/KCNA1 and Kv1.3/KCNA3, has a strong effect on rat Kv1.2/KCNA2 and Kv1.6/KCNA6 as well as a moderate effect on Shaker IR.
Miscellaneous:
MISCELLANEOUS: Negative results: has no effect on rat Kv1.4/KCNA4, Kv1.5/KCNA5, Kv4.1/KCND1 or human Kv11.1/KCNH2 and Kv3.1/KCNC1. Has no effect on bovine KCa1.1. Does not inhibit the growth of Gram-positive and Gram-negative bacteria; MISCELLANEOUS: The primary structure of this mature peptide is identical to that of toxin alpha-KTx 3.19 from Mesobuthus eupeus (AC C0HJQ6).
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).
Sequence:
MKVFFAVLITLFICSMIIGIHGVGINVKCKHSGQCLKPCKDAGMRFGKCINGKCDCTPKG
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MASVAKTGAEALRNAPFRVGKKQIFLPNHVITFVRPLPKQPPNLATFIVPLEFNKLDLRDYLYHVYNVEVTGVRSFVNQRMHEQRHGDVGNWRRPKSQKMMIAELAKPFVWPKPPAEDAREAFDYAMWKKQKTAQEQDTKFQGIRAQGEVVPPSQFEVTKDRKAIKARQSKFLSGEETWAPGKVNAFLNSKIVPEEEGWSEVEENLPLDESAESAAEESSSKGSETRQ
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of RAT1, allowing it to degrade RNAs with stable secondary structure more effectively. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II.
Miscellaneous:
MISCELLANEOUS: Present with 4030 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGVSANLFVKQRGSTTALKQPKEIGFYSRTKDEEYLISDDTNLNYYYLPDAELDRKLDLSSGFQKFKDYYKDFEDRCSLRGLLETIESSERHKGKKINADIITFRGIARKLISCAFDSPSFNTVDLRIVSFNGQLFIKEVPEAVNAAKASSATEAGRNINQDLNVFTGYKFETLATLSNPLQYTPREVIEKRTKRIVSHGDEYISVVRTGVGNCKLILGAEVDCIFDFKENGRDNLKHYAELKCTQQVANISDTHKFERKLFRTWLQCFLVGIPRIIYGFKDDHYVLKTVEEFSTEEVPVLLKNNNPQVGSACLEAIKWYGLLTEWLLKMIPRDEDPHSQIRAFKLVFENNHLRLSEIEESDEEYSGLIDGEHILSNGFKEWRKSLK
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Miscellaneous:
MISCELLANEOUS: Present with 51100 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKSKNHTAHNQTRKAHRNGIKKPKTYKYPSLKGVDPKFRRNHKHALHGTAKALAAAKK
The following text describes a protein:
Function:
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNAPYLQLGARLSQCWLNPYTVICLYILVKIIVFSANFKKNLNTVQTDLVKTCLVSQQATNDLLKTPAVIAKGASHLIASGIQHSVKAMYEVLIDAIIALEGLIIFFIKFIYGTYLCLIQLTVNGSLTAIADVGEKIGDYVNSTLKVIANGIASTVSVFQKVINNVDSRLTIIAKWIGENVTLPNITIPELDKLRNFSIPSSFDSSLEKLKTGINFDSAINATEKVIREPLDKLKVVLKEQVGNFSFNESILPIPAVTTVYYCDDLTTNNAHQVLGIVLRDTIKVVVVILVALCIWFTIPAFFREWWTWTRIRIKASGLLQEFTLNEKLDPIRLVTSVYTPFSSLIRFVCRKLSHSPPVQYSIQWFFLYVTHQPALLILGIGLAGVLASLVQLYMLRKLQAAIPKLSTVANYTMIDTGKILSNVSNVWANETNQVLLNSQNHLNTLLFSYVNSTTSTFNNTLNTFMNGLNGTLFDFFNGTLLESPLQSVMKCLVYNKIENIEKAITWIHEKAHISFPTVPNNLLNDTIANETATNSNNTSNFTRLLSTGVNNTIITFQRSASQELRISLFFVYCWCAICFAGILAIVYSGTQMAYRNYKESRSLLTVNTGSSEKDNKSRSSFEPLIPVPPRSPPPRPPRSPMLSGILRMTGFSERIKDARLRKMELKEQKFPLLSTSKDLATEFPLSPLPLIPSTLIDNPDEVQYAYNDHEDQIRSPKRVSSNVQHIKSMTGTIHL
The following text describes a protein:
Function:
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAELTPYQEGKLDDVSNQDSQSILRQRKTLPHNHTESISSVGDEKSADTEDKSQDQFTWGKTSTGAVFRVPNTHSFVHTLLTTTHRSSLTRLTLFSLVAQPLLFYLLRNHCTLRSAFFLLYFTFWRGCYDWGFAWVLRKQSEKKWVVKLLRNWGWLDVNSEQGGEQGRAWAKWWKRELEMKMDDGYKWESVPQEFNAWLMFRQLVDVVLLNDFVSYSCFAWANLHFPPNHSVSMHIFRWVFGWTLILFNLWVKMDAHRVVKDYAWYWGDAFWLMVMQHDLVFDGVYEIAPHPMYSVGYAGYYGLSMVVGSYTVLFVSLAAHAAQFAFLLWFENPHIERTYGGGKKPLASRVPLAWEQTEYEQEQVEESSTTTVEASEAPTPSATEGETETEPELAELPSVKESNPQIRKPRSDSVFSTTSATTTDGASYGKRFAARKSFSHRAKFTMHDLRHRFFRKPVIIFSRLDMLRSTDFALVLLVTYAISSLIPSLSLNISLAGHFLHALLWRLFHSFGLGLILRAQSKSKWLVRHYLKHYHYPEDAHIDDEDESEIKESVVKRATEESFGNWQVMYNISLVMTYVSFVGLAWKTYHLPSDWTVSGTMLRHVLGLSLIALHIWSAVSSYEVLGDFGWLYSDFFLIEQIPSQLAYTGIYRFLNNPERSMGGAAFFGLWLISNSKLVFALALASHLSHWWFLTFVERPHMQRLYGKRLRKDGGLIKTLKNVAGKTIATKTGKHAHDIQRVVQEVRGSIEKVEEKVTEAVEEFLDHARPMFTDMVHDTRVLLQQSRERMIITRVANDISAYDTSRYGLHIATSSSAPTPRFHVGQPIRVSWTAPSYHSRKDWIGIYRLGSCKSQLVTRVSSVGKWMPIYEEEWNGNDPVDPAEREKKGDSGEVVFRGDQLPWQPGEYELRYHHDGKHNVMSRLAPVEIFVDKPKGGSVKAIHQTLLNIVCVSLDSDPNLVPKSARKKTTPAATPASHVSEVSLREDLPAIQESDGEEAEEGGEGNIEHGQVANEALMPTALRGVNTTGKSTKTPRRSSDKLSVGHANQSDTPPFNTPIASKVPPPSTHSPPSPVPPISSSDHGTPHSSSAHSFTSSNDPDYAGGDGDGDDFVIMTESQAKRIAHLAEMAFGVELSPDVVVAEANVGSLARRIVGARSLIK
The following text describes a protein:
Function:
Binds to nuclear microtubules with the effect of either modifying their structure or function. This then promotes meiotic nuclear division.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Note=Mitotic spindle.
Sequence:
MSYLSVGDEVLIRGELGIVRFAGSTDFESGIWLGVELLNGKGKNDGSVKGKRYFSCEKGKGIFVRACSSNVMKRPSVVKSRKKGSENISNFMEKTKAIKQKSRREPSKFERSLARPLCITPIDSSTPTKTATFYTSSTTENLDELNFSTEELSSFDTTLLNSDTSKLSGLDDSSFMEEEFVWQVDNVLQECEKKFTPHSKGSYLKENLKSELRKGRLDELMCENTALKEKIDKLNKELEKVEPQLTFLRSKNSIEKPRNFRREKFLKKFLAMQKEIKYLRKRKLQIRKIPNYKYSDRSLNSKTPKSQDNWTTQVTPSSLLGVSEVSKVLQLKQVQVDITELVKIPKNPFSEKLTISNVNRYLNIVPGSLDLQFSLTNENFVHWNSTVYQELLNLKSNNSSVDGVKTRRQLLEENALLSHKVLKLTEEIQDLETLNQLNTEIEARQSEKLNEVQEETQRLSQLLISSQPALTEVKHLKLCLSDSQEELLQLNAKLEKANIVIDELNSAKLKLSKQVEEESSMKDDLTEMNQRLKEQIESYENEVNSEITSRTLKEFETLKTQYEKNLCNLREQLKTARMKLADKYPQGDNTSENIDWLKHSLRDSNTENSIPSPLTFACKEIRKLVADIKPVSVEKQLALNWKKDIERPSFHHNQQLFNYCQLTDILSKKC
The following text describes a protein:
Function:
Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.
Miscellaneous:
MISCELLANEOUS: Present with 4980 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localized exclusively in cytoplasmic inclusion bodies under protein folding stress conditions.
Sequence:
MFRVFGSFGSKGNQSSGEEQSTKTKQVLKQANDFEIALKAMDFVLDDRTDEGLNLLKKAEMETGSDQTILTLARGVIEFLQATLSFETEEMKRAAITLGKAEQMSWKSKQNAEKTNFRSSSIYPPGTVYAVTYTESCLLHALLMLFSESMMEAAKALLKLRRAYTMLQDIMVTVKKAERSKNSSSPSPSEKSQESCGSFVSAETTFISVDIPYKLSSEDKSNPLLLEFAEKIYTMRMGRLSGAHIGNTPSFHRLRDDLGLQTTPSQASDRHSVSDDFDLEQATIDEFIHSGANLCYGILQVVLSLLPPAIGAVLSIVGFKGSREEGLRLVWKATKERNVHGCIGLLGLMFYYDGPFQFTDADFDIPPNDNGSRALNKSRTNDSSLLPGYMDSATLLHPGKILEDALLKARALFPNSALWLLNEAKMLAGKGRLRDSLALMDSIDVNSIRMRQVKSLMVFERAILLVNLHEYNRAADDLISLLDISDWSHALYTYFAGCCYLENWRMTQLGLLNDGKEQFYKERARELIFDAPSLLGKKTFKSKNLPLDRFMLRKVQQFNNMQKKLNLQEPLDSIATSPVHELAYFYNGYNRMTENDLILTKKMLTEYHNPAIDSEDPDQELIRNLLLSLTLRRLGDAERGLALLDDIVLPKIFYIQNGKVKYFKKTEDPWAYPAALYERALFCWKLGGMESLNECREWLLRAQNYAADYELSTRIGMKIKAALDRVENALA
The following text describes a protein:
Function:
The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.
Sequence:
MATNNMHNLVTLIKRLEAATLRLEDMASSTIPPIGSQAVIEPASSAPSAPASTAVSTPAPAAAVPIPESVEKFDDFLNQTVQKYVKTSNLIGGLVAEQAASVLKGFAETRKFLLAASQSKKLDMNSVDFQEAIKPISEAIQATQEIKDKNRGSPFFNHLGMVADGIMLLAWITVQSRPDKLIDESLSSAEYLGNRVMQANKNTDPQHTEWVKTFYQIFKDLSEYAKDYYNNGIVWNPNGKPYKEVVQCLESGSAPSAPAASPAPSGGAPPPPPPPPGPPPVLKINEQKAEPAQPGGFSSVMSELNKGEAVTKGLKKVDKSQMTHKNPSLRAGSTVPDGPAARSKSPAPPGTKPPKPESMRAKKPAKKALEGNKWIIENYDAAAGNVEIEASISQSILISRCNEVVIVVKGKANAVNIDNCDKVSLIVDTLVSTVDVVRSKNFQLQVNETIPTVLLDQVEQATIWLSKESISTRVFQSKTDNVNIMVVDENDDSKELPLPSQICSYYDPEKKELISEIVSHCG
The following text describes a protein:
Function:
May promote nucleation of hydroxyapatite.
Subcellular Localization:
Secreted.
Sequence:
MAPGFHFSWLLVSWLVVTTVKGQDVMTPPGSQNNVNPTDCQIITLTPPPTTRNQLTRAQPVTRTPTFYFPPRRPGFYPRFPNIPFFPPNNRRFQLWPFYPPRGRLIPWRFFLGRRQLQSSSSEESLE
The following text describes a protein:
Function:
Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation. Essential for testicular stem-cell differentiation and sustained spermatogenesis.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSAHTGAGVRTGPVPEPKTIAEAPVKRRRTVEDFRQFCSFVLAYAGYIPRPAEELPAPGFCDISPHNSVQCSKDSSDWSSRSGTVQERADGKEIGEPMNLSVVCQPKPLPSVDTEWQEEEKDDVSGQQREDRLSEEQREGERPTEAGREGQARRGRVETEKGGELPGNEEPSWESVAGGNSDILRLVMDGTPRGTVPEDQETGYHTDWDGSTQDQGASDTDQDTRPGDCSTTVGSEEDSWDLITCFCLKPFAGRPMIECSECGTWLHLSCAKIRRSNVPDVFTCQRCRDSKHEIRRSSRARTGPRKRFSE
The following text describes a protein:
Function:
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MESSQVEALKARLLYQDVCRAAQCLDHFLLKGNAHEELFKPHVLALRDMVQQVCIKLMFLHPVEYGRKAEELLWRKTYSDVVLLLLKPNRKNTDSSEEQWEGPLWAHLKGGLRFYEHLFLFLQEHYQLGLWSYIDWPHSAIHFIGCKRAGPASEEEVDWARMACHRCLLYLGDLFRFQNEFLALHTKDLAERCYYRALSVAPHMGMPFNQLGTLTGSKYYGVEATYFYQRCLHSEVPFKGASWNLKQLYHHAGKRYSRLKRNQGKKLSLSQRRCWDNKRLLVSFLYLQSLLQPQRKFRATRLMALCQLVLEDFRLCLSYRPCPSNQSQASRERKPARGYQFLPDLLIFHMVVLCLMSVHSLRTAGSKQHRTAVTFTLTLFSHLIQHVTTRLQAELQKGKLTPEVDVPRDKEDQQKMEAGEGQQDGLAPSPGPRHSKSQKTHRSSHVSSEGDNPEASFHSCCDWDETEEDENTSLCSQVSSELSSETTYSDTTDDEESGSLNPQATQEGGAKSKDRIFPPRDKLKTCQLPSHLLGLLKTTSSASLSAPSSHKLPGKHGFHLAPVFSHSFFTPPSPASSKASVTEDDVSSCLETEPPAGCNLGQNASISQPCSNLQTIQKKLQVLSAEGLLPTVKVILGWLRANCSLLTAHGWSLFSLWDHLSMLLNLLPSVRDLQEPGLGLSYHLHELLQSCKGPHLPQFLKLPEDIALGQHWLKQASQERVGLEQDPPPLSSQDEAAVRVCFLRSFGHFATTLPGQFLRYDSHSGVFVSTGFEGPDNLSQQLLEKTSRIRFFKDIVQLWLQSEVVLLEKTLRHIQIRSALTLYLFPDPRALCEHLPVIRQLATSGQFLLIVPNIVVDILYILRREDKRASAAITFLEGELKRGNQYLLCQSCVSVTLVRPRMTRPDSDAWDLYNMLDICRGLLDSSWLGTPDHRNMITILTGICLDNPRNLSYPLQLVLGTATEAGVEVKNVLRFYRKWKMVS
The following text describes a protein:
Function:
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle. Endosome. Nucleus.
Sequence:
MEAIPRMLMLSVELKESAERVEFGHEIKQHISQHYMEDAAKYNEQIRQLDQFRTNACNVTRDFNGISTLKKYYGQLHLLSSRFPADLFTFSWIDTFDEEPYTHTDILFEQSCILFNLGTLHSILGAIESRASEEEMKVACTHFQCAAGAFTYLKDNFQCDMSPDISFELMNMYINTMLGQAQECLLEKSMQDNRKSSLVARISMQVVEYYRQALKGLEDSNISSLMGSRRNKWWKKTLQIKAHHFTSIAYMFMSNQAEEQQKFGERLAYLTYAQTKHNEAVKMSKGQPESITEALNFAKDVVIGKFQSAKKDNEFVYHDSVPSFESLPEIKGASLVKALTFQPYDEAVAGHDIFRKLVPMEAHEASSLYSEEKAKLLRRVVDNIEDKNKKLDQYLAAVQLEQLKLPGSDPEVLPQVLLEVCAALSVKTEPIKTLVSSMKELSGVVMDVDSSLKEIEQLIEQDGKQETESQLEFGTKSAKSLEEMKKDLTKCKELHATASQSNTELHKAMQTHMENIKLLASPVETLQATLPSAKGARNEDDDEAERKMQKLVTKVDEMKTQRQTLEQQLRDHIRDDDVTGGIVTRTKGSMQEFFQNELKKHETLITYLEQNLSAQDNILKAMTEANASYAERRKMVTNIGSKREEKIGELISSYTVYDDLIEKSNKGIGFYKKLEGTVTKLLNKTKGVAKANHEERQEKTRKKYPPQRPAAPKPVSSVAGYPVLGVAGQGLQIGPTGLVIAGPLGPPEPVPVSSAPKGPKLSDYWKPKAGRTAQPPAAQPPPTQPHVFPGMPVSAAPAVSMQGPSQGPYSQARMPGGGMHQAPVALPGAQPLPGSGAVLPPVAPQVSMAQPRAPGQYVSQGGQGTRPVAAVPPSNAGQPIPAGHHQQGFPPSSRAMPQEVQMPPQNISQGPHASPVHQSRVPQHPATSMTRQDSFSSNSSQSPVHVPQQVPGGAQVQPGQAVQASQMPLSGQPGAVHANPPIPGQNYNQHQVGPNQVGMPAGVQQSPHPAQSMAHHPAAFPSHQIASSGQQIPSSIPSHSQQQPIAPQSLNNQPPVQPPAYGSEQHAIAKAASMGMSTASMQPGVPPQGTPPSSYSSAHLPSATNTTPSHMPGNSVPNQLPNQQQYIAPGNIPLAHGGQPIQNTAVQPGASVVNNTQIGNIQMPSQVGMPQHQPNLPHGQQGGNLQQQQQPPNSGVRTVVPNIQAVQPSAGTGSFPQQQGNSQMIRPQQQQYPEQQSYQSLKSQPQPQQTSMQQTYPQIGNKVQPSQQYQTPPAAPHQQPQHLQQQQQHPQQGFVSQQPQVQPGHQVPTPHQQNVPAQQQQPNIQPGNQVPTSHQQNVPAQQQQPNIQPGNQVPSSQQNLQMQQPQAYHQGYNKSPQQQINLPLQQPQGYQQTPGGTPYQSSPSKQCVPSGQPQGGMPPIAGNSTGQQVPSSIPQQVTVRPGSYQQIPQQSHQQPQQNLQQPGVQQQQINHQQYPAQGQQYPAQQQQHPPQQQQRPTQHHQHPAHQQQPAHQQHPPKQQQQPVPQQKHPQPQQFSAQQQQQHLSQQQQQHLPQQQQQHPPQQQQQHPPQQQQHPPHQPQYPPQQQQHPPQQPQYPPQQQQQQQQQTFPQQQPMPQYQQSQQHMQQPPPPAPNSNIVSQSNIRPQFQQNPPQMQQPLRPISSVQQITQKQSFEQQRLPQPVLQPMKASAKPATDLLSTSPDRQNQPLNDVLAPHSVAAKAEVQPEATQPAADPNSNVSVLASIEVQPNSIPQSQQLPSQISNSSHATVPSTSSTTDMLAALKLQPALSSPPIIAATRPSTTSNLQQPPQRTPSKPQESSAATQSTTLATLPGDKNSYVDKESLEKFVEEVERLDMYVEGLNRKMLSGPTVIERLWKELTNYQDRETRQFSIAIARCYSVKNRHPDIMPYDHNRVCLRGTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREINEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALAKRGVATKSVAAASPLDAKLAPSRLNSFDVIMGTDNVDTLISRISKFSVKPNQPPATDTVKEEVVPSECAEVENVAPSQSNDGDSVFQQETVGDKVNGDMVFQGITGDSLQDPASNSTQGLLSDTGSSTPSGISSFTSSPAHSNQKPQSLDQLQVNNLEVFSQTLQNFVAPDVVESSTKQDKADNTSEGSGSMEGPSSSLPSLLADLTPQNFSMKEKGQTKQKVSKADFLDGKGGLKDSVDKVDPDDPFSGLDPMWTLKNKSSEPIQQ
The following text describes a protein:
Function:
Stimulates smooth muscle contraction. Role in induction of hypothermia, stimulation of DNA replication and release of many gastrointestinal hormones. Possesses insulin-releasing activity.
Subcellular Localization:
Secreted.
Sequence:
MSAIPLNRILPLGFLLIFSFISLSSCMEFVEDPNNQGGLNLQQRLGNQWAVGHLMGKKSLQDTDFEEMESFAKRNVENMKAESERELRHAQLVVRNILEQYLKNMQN
The following text describes a protein:
Function:
Efflux-type boron transporter polarly localized in roots. Boron is essential for maintaining the integrity of plants cell walls.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEEERVDSSKRLFRGIVADLRGRALCYKEDWVAGLRSGFGILAPTTYIFFASALPVIAFGEQLSRDTEGALSTVETLASTALCGVIHSILGGQPLLILGVAEPTVLMYVYLYNFAIGRPELGKQLYLAWAAWVCVWTALLLFVMAILNTADIINRFTRVAGELFGMLISVLFIQQAIKGMVSEFGMPKDEDSKLEKYKFEWLYTNGLLGLIFTFGLLYTALKSRKARSWRYGTGWYRSFIADYGVPLMVVVWTALSFSTPSKLPSGVPRRLFSPLPWDSPSLSHWTVIKDMGKVSPGYIFAAFIPALMIAGLYFFDHSVASQLAQQKEFNLKKPSAYHYDILLLGFMTLICGLLGLPPSNGVLPQSPMHTKSLAVLKRQLIRRKMVKTAKESIRKRETSSQVYENMQEVFIEMDKSPLAQTDPSVIIELQDLKEAVMKSNDEEREGDEESGFDPEKHLDAYLPVRVNEQRVSNLLQSLLVAGAVLAMPAIKLIPTSILWGYFAYMAIDSLPGNQFFERLTLLFVPTSRRFKVLEGAHASFVEKVPYKSMAAFTLLQIFYFGLCYGVTWIPVAGIMFPVPFFLLIAIRQYILPKLFNPAHLRELDAAEYEEIPGTPRNPLELSFRSNDSKRGVQEGDAEILDELTTSRGELKVRTLNLNEDKGNQIYPKEKVKAGDGDMSTTRE
The following text describes a protein:
Function:
May play a regulatory role in spermatogenesis.
Sequence:
MAQAQEDSDPIGSILIQVHEDLHQLKEKLVKFSAEETRSTLDIQNLETAIQRTEMGLKIHIDKYLGVVNQEVLMAPVKKSLESPVTSKWSIPTVIDQKSFIFPMDSDFWRPQKHRGSLLHGLRRAKPKIQLTTKVMQDPENKHHRAAVTASYGISLPHINQRKAQDKVQRLIKGSTISNLTVLPPSHRTDPHFIPIPVLQKDASKGVLSMIERGLIPPTARITFQNPPIKPQALPLHSFDEHRKVPMEASFPLALKPRPVPEEVEEPSHQIEIPKGRAKRSRGPLRRKGMKIRTPSKTRKSPWDYIFSVYNGCVDRTAPDFLAFKSRFKLIWGSIFSFLEQIEKFLKDYAISEAKIKGKSLVSLLPEFELKNKLTRNDVLAVLENPVHIQMLLNLPGQRYKGQDGKAEAATKIQATWKSYKARSSFISYRQKKWASGVIALAWLLHCHRTRLKRIVKESRQRHLENFRIRAQHLAANWSRIRTSRRTIIHIPSLGYSQYVRKHIFDLDVEQNMQLGRLCDIIDANVNVIYICSHPMTDELKLYYRKLLSLQAAVKTGYYGDRTDLQNRFRIITPEAVNVFTKHHMCLATHLMYSPKAIKRIKNLIRGEEAYIVGGILHRDDLAVADMLNVPILGSEPELVHLYSAKSGSKRIFDNANVPMPPGIYDIYTYQQMIEQLSQLVTDNLGIRRWVFKMNTEFGGNGTAFCDIPSHLQCYNWVLKERNRFGHEDWKKKWAQESALVKISEELAGILAQHVQLVNEKRFPTWRKFLHMFLTQGGVIEAYPPADSVTNLTVDMLIEPDGEVRVLSMGDQLHADGPFISSGTTMPQTSVDPQVLNSLCLQIGNICKEKDVVGYFSIDLVTFIDPSTLEQQVWTTGLNLSYSDQLAMTQLTLYLTNGHLNCSLSTLEVPRFTEDSERERKRLSIQAELAPETSRYAVMSTQLKHDNLSLIFYYVFLQMCKAHGIGYDLEDRQGTVFILYESLKRYKLGMLTIGVDLQGVLMTFARNLFIIHQEISAPDMQGETNFKTTIDDIETILGVTEENKMIFVREKQSKEEEDNLYEPVEIHSEIV
The following text describes a protein:
Function:
Involved in spliceosome assembly.
Subcellular Localization:
Nucleus speckle. Nucleus, Cajal body.
Sequence:
MQGQGVDEVSIEELASNLSLYKDQLNQVRELLNDDPANSEYVDMERELSEVIALTEELLATAKQNEISAPPNNAAASPTLSIHNENQLLDSSSDHQEKLPVGTKVQAVWSEDGEWYDATIEAYTPNGYYVSYDNWGNKEEVDPANVRSIQEGSVDALLEAERVAEATKQAIKRKIAQAASIDLQSRSLPTKLRIEADDPEDVKASKRKKIHAFKSKMRMEQLEVTQNKRQNAWQQFQSTKGKAKKIGFFSGRKRESIFKSPDDPQGKVGVTGSGKGLTEFQKREKHFHLKDGTVENDD
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MPGDKKIANPQLSAAVLKSDACAYFTNRNMIPGKVGIPSENVVSSVNAGFGNMKVSEQSVHYPSSICYDHHYPGPNENHHQLGGSCSCHQNCNGTLYKDNGSPLYYTHRGYNPYAFTSVDPQFSSSECYSMNCARYQDPTSYGSRYTMCSDGSLKSSGINTKRSMTAFDERFPSYLLDMQSRQSTSNISQSVLQSSHLCSLNKLGAACHSGSATKGYQQCPNMSSFGYQDLFADYSMIHAPKIRESEELTCGPRAQSTMIEHNEAEHSLKNKYNLDGFQTKYEEAKFFIIKSYSEDDVHKCVKYDVWSSTPNGNKKLDDAFLEAQGKSGSKCPVFLFFSVNGSGQFVGVAEMMGPVVFEKNMDFWQLDKWSGFFPVKWHIIKDIPNSQLRHIILENNDNRPVTYTRDTQEVGLHQGLEMLDIFKSYPSKTSLLDDLSFYEKREKLLKARRIGKLAFQPENNTSSGKGSMSTNGSLDPVSSIIHITRNLSLNTDMPKDKSL