lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Snake prothrombin activator that attacks the hemostatic system of prey. This protein is functionally similar to blood coagulation factor Xa (By similarity).
Miscellaneous:
MISCELLANEOUS: Is classified in the group D of snake venom prothrombin activators, since it requires the mammalian factor Va for maximal activity for the cleavage of prothrombin; MISCELLANEOUS: In contrast to blood coagulation factors that circulate as inactive zymogen in plasma, venom prothrombin activators are always found in the active form in the venom.
Subcellular Localization:
Secreted.
Sequence:
MAPQLLLCLILTFLWSLPEAESNVFLKSKEANRFLQRTKRSNSLFEEFRPGNIERECIEEKCSKEEAREIFKDNEKTEAFWNVYVDGDQCSSNPCHYGGTCKDGIGSYTCTCLPNYEGKNCEHLLFKSCRFFNGNCWHFCKPVQNDTQCSCAESYRLGDDGHSCVAEGDFSCGRNIKARNKREASLPDFVQSQNATLLKKSDNPSPDIRIINGMDCKLGECPWQAVLLDKEGDVFCGGTILSPIYVLTAAHCITQSKHISVVVGEIDISRKETRHLLSVDKAYVHTKFVLATYDYDIAIIQLKTPIQFSENVVPACLPTADFANQVLMKQDFGIISGFGHTRSGGQTSNTLKVVTIPYVDRHTCMLSSDFRITPNMFCAGYDTLPRDACQGDSGGPHITAYRDTHFITGIISWGEGCAKKGKYGVYTKVSNFIPWIKAVMRKHQPSTESSTGRL
The following text describes a protein:
Function:
Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, M line.
Sequence:
MTGIAVCVGTVSSIKHLWETKIKKARDDLQRQKELRDRASVGRLAHVWEDRITLARLKQKVVTEEGRIILRIEKEEWKTLPTALLQLANLQEWQLHRTGLQSIPRFIGSFMNLIVLDLSRNAIREIPKEIGQLTRLRELLLSYNRVKSIPEDLSACESLEKLELAVNRDLCELPIQLSRLKNLSHLDLSMNQYTAIPDAVISMPALEWLDMGVFHRMENLHTLWLQRNEIRFLPDSISKMTNLGTLVLSSNQLQDIPVCMENMVNLRFVNFRDNPLKLKVTLPRMVMSEEDEDDREMFGREFMQAYIQESKSRDTKINFKSVLNVAIEAVQEDSLGL
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAGMYNQDGGGGAPIPSYGGDGYGGGGGYGGGDAGYGGRGASGGGSYGGRGGYGGGGGRGNRGGGGGGYQGGDRGGRGSGGGGRDGDWRCPNPSCGNVNFARRVECNKCGALAPSGTSSGANDRGGGGYSRGGGDSDRGGGRGGRNDSGRSYESSRYDGGSRSGGSYGSGSQRENGSYGQAPPPAAAIPSYDGSGSYPPPTGYGMEAVPPPTSYSGGPPSYGGPRGGYGSDAPSTGGRGGRSGGYDGGSAPRRQEASYEDAATEKVKQCDADCDDNCDNARIYISNLPPDVTTDELKDLFGGIGQVGRIKQKRGYKDQWPYNIKIYTDEKGNYKGDACLAYEDPSAAHSAGGFFNNYEMRGNKISVTMAEKSAPRAPTFDQRGGGRGGGGGGYGGGGGDRRRDNYSSGPDRNHHGGNRSRPY
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs.
Subcellular Localization:
Nucleus.
Sequence:
MSCAEVMYHPQPYGAPQYLPNPVAAATCPTACYHPAPQPGQQKKLAVYSKMQDSLEVTLPSKQEEEEEEEDEDEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDEHFSRALGQANTLHPESAISKSKMGLTPLWRDSSALSSQRSNFPTSFWTSSYQPPPAPCLGGVHPDFQVTAPHGTFTTADPNSWPGHGLHQTGPAPPPTASESWHYPLASQVSPSYSHMHDMYMRHHHPHAHMHHRHHHHHHHPTAGSALDPAYGHLLMPSVRAARIPAPQCDITKTDLTTATTATSAWAGAFHGTVDIVPSVGFETGLQHQDKSKESTWY
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIDPIFASCTLIAVFVVLLAMGAPIGICIVIASFSTMMLVLPFDISMFATAQKMFSSLDSFALLAVPFFVLSGVIMNSGGIAARLVNFAKLFTGKLPGSLSYTNIVGNMMFGAISGSAIAASTSIGGVMVPMSAREGYDRGFAAAVNIASAPTGMLIPPTTAFILYALASGGTSIAALFAGGLVAGVLWGVGCMLVTLVVAKRRNYRVFFTVQKGMALKVAVEAIPSLLLIVIIVGGIVQGIFTAIEASAIAVVYTLLLTMVFYRTLKIKDLPSILLQTVVMTGVIMFLLATSSAMSFSMSITNIPAALSDMILGISANKLVILLVITVFLLIIGAFMDIGPAILIFTPILLPIMAKLGVDPVHFGIIMIYNLAIGTITPPVGSGLYVGASVGKVKVEEVIKPLLPFYGAIIGVLLLITYIPEITLFLPRLLGIM
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, a RING-box and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Subcellular Localization:
Nucleus.
Sequence:
MAAVKEGADAGDSKILLISSDGQHFQVTEAEASMSKLVSNMIEDGCTENGVPLPNVASNVLAKVLEYCKKHAAAAAAEDVAVKDQELKSFDASFIDVDNTMLFNLILAANYLNVPSLLDLACQHTADLIKGKTVQEIRDMFGIVNDFTPEEEEEIRKENEWAFEN
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Acts as a 2-carboxybenzaldehyde reductase.
Miscellaneous:
MISCELLANEOUS: With 4-nitrobenzaldehyde as substrate, it exhibits a substantially greater specific activity with NADPH than with NADH. Conversely, it has a 1.8-fold higher activity towards succinic semialdehyde with NADH than with NADPH.
Subcellular Localization:
Mitochondrion. Golgi apparatus, Golgi stack. Cytoplasm. Note=Its association with the Golgi stack may facilitate secretion of GHB.
Sequence:
MLRAVSRAVSRAAVRCAWRSGPSVARPLAMSRSPAPRAVSGAPLRPGTVLGTMEMGRRMDASASAATVRAFLERGLNELDTAFMYCDGQSESILGSLGLGLGSGDCTVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHGTPIVETLQACQQLHQEGKFVELGLSNYASWEVAEIYTLCKSNGWILPTVYQGMYNATTRQVETELLPCLRYFGLRFYAYNPLAGGLLTGKYRYEDKDGKQPEGRFFGNSWSETYRNRFWKEHHFEAIALVEKALKTTYGTSAPSMTSAALRWMYHHSQLQGTRGDAVILGMSSLEQLEQNLAATEEGPLEPAVVEAFNQAWNVVAHECPNYFR
The following text describes a protein:
Function:
Vesicle trafficking protein that functions in the secretory pathway.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MTVIDILTRVDVICQKYDKYDAEKLNGANVAGEDPFARLYGSVDAEISYLLLQKAEAARQEKNRATVVALNTEIRRTKASSSRRTCPSCSASRSRSTERITKIKLVVLYKCSSSCCECILILRLTLFYGNFDDEYFKGTEESNKFCQEYEMRRMKQDEGLDVIGEGLATLKNMSSDMNEELDRQVPLMDEMDDKVDRANADLKNTNVRLKQTILQVKVHSSPCIILISPPTFTSK
The following text describes a protein:
Function:
Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Also acts on nicotinyl hydroxamate.
Miscellaneous:
MISCELLANEOUS: Has a cis-peptide bond at 162-Val-Ala-163; MISCELLANEOUS: Present with 7720 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Peroxisome. Note=Concentrates in peroxisomes.
Sequence:
MKTLIVVDMQNDFISPLGSLTVPKGEELINPISDLMQDADRDWHRIVVTRDWHPSRHISFAKNHKDKEPYSTYTYHSPRPGDDSTQEGILWPVHCVKNTWGSQLVDQIMDQVVTKHIKIVDKGFLTDREYYSAFHDIWNFHKTDMNKYLEKHHTDEVYIVGVALEYCVKATAISAAELGYKTTVLLDYTRPISDDPEVINKVKEELKAHNINVVDK
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Sequence:
MPAAVEIYTRPGCGYCSAAKSLLTRKKATFTEFDVARNPSWRDEMYDRAGEGSTFPQIWIGGSHVGGCDDLYALDREGKLDGMLESVKAES
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASTLPIPDINVIAPSFIQRDSQNSDNMKPPPTDFNHPYTPYPIQTAFMQTLYSVLDRTVAVSPPTTTNSTNNTAPSATFSSTAATLIPSNPSTSPSTPPLINPTTAPTVHLADRATEPSLSVTPRTTTSKDKDKGPSSSSSVPKGHAQIALFESPTGTGKSLSLICGSLTWLRNHKRLQFDSEIEKIQQQMEASGEPEWMVESAIKRKREELAQKYEEMERTLERIRQKEREMEKEGEEGQARGGKRRKLDRGKGDEEKGGKKKESGGSRGLTASDEDKEFLIGDWRDEGGLDENDPMGQLSKETRELLEKVGMGTAGGKKEANEGPVAEEEIKIFYTSRTHSQLTQFIQELRRPEFPASVPTPNPQEKPAKEIVKQIPLSSRQKLCINPTVNKLGTLAAINERCQSLQQPKTPKDQRCPYLPNAANLKATHEFRDTALATLPDIEDLYQTGKQLQICPYYASRAAIPGAEVITLPYPLLLQKSAREALGIRLEGNIVIIDEAHNIMDAVSNVHAAEIKYTDLKRAKLSLGMYYQRFHQKLTGENKVMVAQLQRVVEALGVYLKTKLDKAALGLKADQEGIVLDTSLLLKTGGADQINLYKLIRYVQESKLAFKIEGYISYCEEEGRDTDDEEAETEIKARQGRPPVLHTLCSFLTALTNLSSEGRIFYEKIPPPRGELQDMKLSYMLLSPTHAFSSIAESARAVILAGGTMSPFEDYKAHLFPDVPPEKITTLSCGHVIPPDNLCVWTLGSIAPNPKVDTGIGEDCFDFTFAKRSNPNMINRLGLVLLNLCSVVPDGVVAFFPSYGYLEEVIGVWKTHEQAMGPKTIWERLESKKALFIDSKTESSEQTLQKYSDVIHSEVRPLSPAGSRVKGAMLLSVIGGKMSEGINFSDRLGRCVVVVGMPYPNPHSPEWLARREYLEANFIKRYTASQQTSTATAPLPAPVIPPPSNTTHYSTNPSSSRNKDKHKPANVRKLAARDSHQFYENATLRAVNQSIGRAIRHQNDYAAIVLIDNRFEKEHVRAKLPGWIREGWDETQRQAKEDGKALKGLQGMMGRVNMFFRGKN
The following text describes a protein:
Function:
Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to centrioles at all stages of the cell cycle, including mitosis (By similarity).
Sequence:
MDKMNPPALGQASALFPDLEPPGGVGKATVLLGGSTGLTSSDMEFQKMLIDERMRCENHKTNYQTLKVEHTRLQDQYTRAQNELKRLLSDRQVTQEKQQLLLAELRGELLDKTRDLEELKLQVLTPQRLELLRAQVQQELEAPIRERFNKLQEEAENYRSEYNKLRYDLTFLKSEFDHQKEEHARVLEERRIRHEADVARLEHDKEDLATQLQSGDPARDGKRVEALLREKAQLHQRLRGLEAEVTELRAERNNSGAQAENVQRIQIRQLAESQAAVKALEAEKQSIRMQLDRTESELRLSQEQNTLLTGKLHKAEREINSLNSQVEEMKHTHKLELSNVKLECVRSKGELERERDMLQCQVEGLQSDIEVMKSALERNKELISEKEREMVRRVQAAREEEIHKMATLQEEKLELENRLSELEQQKALQEVTGNSQKEEWEERLRAAQLGEESVRKELQNLRTKVQQQGQQLEELETLKAENADLRQQIAELNLQVGTLSHSESELLDTNNRLRESLERVREDLRSARTQMERTQQEAERLVEERRVEWLEEKHKLQDIEAELREKYSQAKERLQRAAFAQKKRKTMTELKENKLKDKIQLLEAKIAELEIEAKHAQLSKRLRELQRRHNEFRRLLLGNQMTSSTPLAQSLLIPNESIFSNIQVSEEQHQRELCVLRRRLEELENSQQQQLEELAAPLDRDRERLSSPRDALPDLS
The following text describes a protein:
Function:
Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAKIELKPVGTNLLKSVSGESVELQSLWRDKPVVLFFLRRFGCQVCRWTAAEISKLEPDLTAHGIALVGIGPEETGLKEFKEGGFFKGDLYIDEKKQCYKDLGFKRYTALSVVPAALGKKIREVTTKAKAQGIQGNFTGDLLQSGGMLIVAKGGEKVLLHFVQDSPGDYVPLEDISKALDISANVQAGERPQCNDDVCTR
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAATAVRPITGMLRRGLILDIGIALGVGFVMANGYWYGYHMPRTNARDNYYKKLEEERAARMGA
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MSEEDSLLTNLCAICHIQPPKYRCPRCSTRTCSLPCTRRHKLWSQCSGVRDPAAYLRRNELATESAFDRDFNFITSIERRLERASRDAENRGVVVDGRQGVREPGIVGLDEDELGQADAMDGRKRKRAGPGAGNGIGHGFERGLAKGEAGFLKRAAEAGVRVIKAPKGMSRAKMNGSRWHTKQKCLQWTIEWVTDNGTKRMNCAETATVAEAYDRAFPLTREERQVRTEESTFKSEPKLASAQEPAKESTQETKNVEPDKNAEPSQSQSQTHQPPKSDMSFSESMPETAQPHVLSSNNHPTPAQDDTTQPTSELPSPSTEPPLPYRSVFFYIHRPRTTTKRPVLAPLSPGMTLTSALQDRVVLEFPTIYVLQNPLMPVPDTSCVTESGPGPLGKSNLKQRFILEAEYLRAHPDEAAAGTASAVTAANDGEQLEDTEALFGVGAVNIPNVDEGKILEVLEKDLLGSS
The following text describes a protein:
Function:
Component of the nuclear pore complex that has a direct role in nuclear protein import (By similarity). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (By similarity). Binds to transcriptionally active chromatin sites when located in the nucleoplasm and is involved in transcriptional activation.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus envelope. Chromosome. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Associates with chromatin.
Domain:
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
Sequence:
MAGKRQATSNLNHENWDLEEEPEERGTFRTATEEELKTRVIKKARRKIAGGSSAAEEDGAEEKTAEPKSVFSGFSGFGKPAASPAAGSPFSFLANVTAPATTSSSEPKKSAFSFGFSSSSSSADRPVSTSICGTASTSSTAPSPLPAKESTSTVDGAKPTTSIFGNISAAKKESSEAKTSSSSTSLTSTMETSEYRESVADLNRSVIKFLQDQMGKSPYCILTPVFKNYDEHLKDLQDEESARTNSTKSKTAQARSQEPVAKVSRASSPPKAATTFTFGKPSAPIGASVSPLAKKPNCTITSGGTTTTTATPLVSFGSTASFTAPVPSSSSIFSLTAKPTGEAKSDDTPKSSIFSFGAKDTTTKKDEPNFSAPKTNGFSFGLKSNNDDKPSTSLFAGFGKAPGGAGDGAKGFSFTNSATPFSLGNIHPPAAAAAPAEEEKEEDTPPKVEFKQVVEDDAIYSKRCKVFIKKDKDFGDRGVGTLYLKPVKDSEKIQLLVRADTNLGNILVNLILSKGIPCQRMGKNNVLMVCVPTPEDSKATSLLLRVKTGDEADDLLEKIKEHIK
The following text describes a protein:
Function:
DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
Subcellular Localization:
Nucleus.
Sequence:
MDAEAARSYSLEQVQALYSFPFQQMMAEVPNMAVTTGQQVPAVAPNMATVTEQQVPEDAPVQEPAPEAPKRRKRKPRAAEPQEPVEPKKPATSKKSGKSTKSKEKQEKITDAFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNADVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCNGEPCGIASNGLTAHSAEPRGEAAPSDVPNGQWMAQSFAEQIPSFNNCGTREQEEESHA
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
Sequence:
MDLSSLTGKSAAAGGATSAERKEAIKQQVSSELAMANAQQLITKATEKCYSKCIPAPGASLSGKEQTCLTRCMERYFEAFNIVSSTYVRRVSNERAAGAVAEAGL
The following text describes a protein:
Function:
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVPF
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKQQSLFSFSILLLFLHSTKTFAQSPAAAPVQAPPVAPVQPPPAPPAQSPSGVQVAPSPGPLDVVKILGKASHFTVFVRLLKATQVDTELFLQLNNTNNGATIFAPSDGAFSGLKVGTLNSLSDGDKIELVKFHIMPTFISTSQFQTVSNPVRTLAGAGNRFALNVTTAGNLVNITTGLTNTTISGTVYTDSRLAIYQVDKVLLPLDMFTPKSPPPAPSPAPAPENPKKAPIIESPVAPKDISGAVSLIVQNHLVLGFVAVGVISAMLSF
The following text describes a protein:
Function:
Can function as either prephenate dehydrogenase or as arogenate dehydrogenase in the biosynthesis of L-tyrosine. Catalyzes two analogous reactions: converts prephenate to 4-hydroxyphenylpyruvate and transforms L-arogenate to L-tyrosine. Is not able to utilize NADP(+) instead of NAD(+) as cosubstrate.
Sequence:
MTVFKHIAIIGLGLIGSSAARATKAYCPDVTVSLYDKSEFVRDRARALNLGDNVTDDIQDAVREADLVLLCVPVRAMGIVAAAMAPALKKDVIICDTGSVKVSVIKTLQDNLPNHIIVPSHPLAGTENNGPDAGFAELFQDHPVILTPDAHTPAQAIAYIADYWEEIGGRINLMSAEHHDHVLALTSHLPHVIAYQLIGMVSGYEKKSRTPIMRYSAGSFRDATRVAASEPRLWQDIMLENAPALLPVLDHFIADLKKLRTAIASQDGDYLLEHFKESQKARLALKTDHDIRP
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Domain:
The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes; Both IUM domains are necessary for efficient binding to ubiquitin.
Sequence:
MSRWWNSNSQFASDIEKATSETLPAGSEEISLYLEISDQIRSKSVDPKFAMRILKSRIDHSNPNVQIMALKLTDTCVKNGGSGFLLEIASREFMDNLVSILRSPAGIDEDVKMVILRYIQSWALAVPDTNSPLSYIIHVYQNLKDGDYEFPEPSQNITSKFLDTETPPDWTDSEVCLRCRTPFTFTNRKHHCRNCGGVFCNQCSSKTLSLPHLGINQPVRVCDSCYSLRTKPKGSKSRARNERKFHAKTRKTPSKPVTNNEDEDIKRAIELSLKEMPQSREPPSYERPSEANVVISQDQHLTEDEDEELKRAIAISLEEAQKSSQKDDNVTAPNNMNISYPSVPAHTVSTDIRSSPFSGRPSDNPSTLISTADADNITLYATLVQKLKKLPPGSIFTEYQLQELHENMGVMRTRMMRSLGETMSKYNGLIQALQKLQTCMRLNDALIEQRLSSTYAHHYIDSSMDSNRSIEPEPDVISTVRNSSTIPQASSSSVPKIVVDSSPVTENPPSHSDVMGQKDTISSYYSTDTDVSANVMGNRHDEVVFSDTASGEKNTKLNIDESTNYYNTDSIDKVGEPFDEISSGYDDLMNGNDKQGNDIPEVQEASLIEL
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
Sequence:
MWCEHPREYRALRSYCFLRRFVCDQSRHRLALISTLVRSNSPLGAIRPLADQTVRLLAAGEVIDSPAAVVRELVDNSLDAGADRIRVSFWPESWRVQVQDNGLGFEAEELPMAARSHATSKLGAIEDLWRLRTLGFRGEGLHSIAVVARLEILTCTPTARTATRARYDHKGELVESQPAAAAPGTVVTVSELFELQPVRRRFLADTKAQVRAVTQLVHRYALAYPGHLFELAVDGRLQLQLWAAPGLKQRALQLLNSYDEHDLREVHLERDGRRVRLAIGLPDRCSRARADWLQIYINGRFVRHGELEQAVRAGFERTLRPGRQPVCIVQLILPADEVDWNRHPAKLEVQLAGTAPACELVVAAIGEGLRHFAPKPAAALLRLAEAHLPYAAESTGGELLLKALAQLHQTYILAEYPGGVCLVEQHVAHERVLFEALESDWQVVPLEPPLALELSSRQAQNLTEHGIEVEAFGERSWLVRSAPVALVGRVDCAEGLMELADQEDAAQMRAALSCRTAIRNGTALSPLQMQQLLDRWQRTRNPHTCPHGRPIYMPLTDGELARFFRRRWHICGS
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGSALENYVNQVRTLSASGSYRELAEELPESLSLLARNWSILDNVLETLDMQQHSLGVLYVLLAKLHSASTANPEPVQLIQLMRDFVQRNNNEQLRYAVCAFYETCHLFTEFVVQKNLSILGIRIISRAIDQIRQLETQLTPIHADLCLLSLKAKNFSVVLPYLDADITDISTVAAECKTQQQQQSQHADANNDAKYFLLYFYYGGMIYTAVKNYERALYFFEVCITTPAMAMSHIMLEAYKKFLMVSLIVEGKIAYIPKNTQVIGRFMKPMANHYHDLVNVYANSSSEELRIIILKYSEAFTRDNNMGLAKQVATSLYKRNIQRLTKTFLTLSLSDVASRVQLASAVEAERYILNMIKSGEIYASINQKDGMVLFKDDPEKYNSPEMFLNVQNNITHVLDQVRQINKMEEEIILNPMYVKKALGSQDDDLTSQHPKTFSGDPTD
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MSSPPQSTNQNNSNPAQDSLERESGSISQSQQPPIVSSPLFFNSSNPGSDIGNFNSQSQSQSQSQRRNDISSPLHYTSSAQPTSDIGGFDSQRSARVQDVGRIMRRAQRSDVTDSVSSPQRSRRYFTQGRGNGPSNLNSSTSAQFSTDPAEPNDEPVRVIWGTNVSIQECSNIFRDFLLSFKYKYRRELEEQAIEPEDHELYYVNQLNNIIELGLTNLNLDAKNLLSYPSTRKLYYQLINYPQEIIPIMDHTIKDCLIQIINDANATTSPAQSKLDEIETNVYTIRPYNVNLVEKGIRELNPNDIDKLVSVKGLTLRSTSIIPDMKVAFFRCNACGHTVGVEIDRGVISEPTKCPREVCGQTNSMVLIHNRSSFSDKQVIKLQETPDLVPDGQTPHSINLCVYDELVDSCRAGDRVEVCGIFRSTPVRANPRQRALKNLYKTYLDIVHVKKIDKRRLGGDVTTLEHELAEKDQEVEQVRKITAEEEAKIKEISERDDLYEILARSLAPSIYEMDDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKIAPRGVYTSGKGSSAVGLTAYITRDIDTKQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTISIAKAGIITTLNARTSILASANPINSRYDPNLPVTGNIDLPPPLLSRFDLVYLILDKVDESIDRQLARHLTDMYLEDAPETVNANSVLPVELLTLYIQYAKENFNPVMTEEGKNELVRSYVEMRKLGEDARSSEKRITATTRQLESMIRLSEAHAKMRLSERVELIDVKEAVRLIKSAIKDYATDPVTGRIDMDMIQTGTTAQQRRVQEDLVSEIMKIIEENNNLIRFNDLSVKLNERSSFRVENSVINEGLRRLQQEGKIMETGDSHRRTIRKIAIV