lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (By similarity). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (By similarity). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity).
Subcellular Localization:
Cytoplasm, P-body.
Domain:
The NHL domain, containing the 6 NHL repeats, is necessary and sufficient to target RNA but not to repress mRNA. The minimal region needed to execute repression consists of the coiled coil domain and the Filamin repeat. The RING-type domain is dispensable for mRNA repression.
Sequence:
MASFPETDFQICLLCKEMCGSPAPLSSSSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRVMFTPPDQALYLALKSFGFVSSGAFAPLTKAAGDGIKRALQGKVASFTVMGYDHNGEPRLSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPVLSFGSEGDGEGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPEGLIVVVDFGNNRILIF
The following text describes a protein:
Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone.
Subcellular Localization:
Cell projection, filopodium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MVVRELNNNWQSHAFDGYEVNWTEQQQTVSCLHTLGYPPAQGQGLHVTGISWNTTGSVLACAYGRLDDGDWGTLKSYVCTWNLDRQGLNPHQPSVVVEVPSAVMCLAFHPIQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGRVLLWRGSGAGQLRLSKGFALAVQQLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLAAEAAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGVVKVWQLSTAFTEQGPREAEDLDQLEAEIAT
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Subcellular Localization:
Nucleus.
Sequence:
MAASGLDHLKNGYRRRFCRPSRAHDVNTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQLVVEPSEATNRSVQAHEVHQKILATDVSSKNTPDSKKMSSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVVPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFDGKVMLKKIEIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQKQRRKFMAKPAEEQLDVGQSKDKNIHTSHIIQDEFQRNSDRNMEEREEMGNDCVSKKQMPPVGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPVYSNSSVRNELPVHHNSSQKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGSGGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKKSKVIPKNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDLVRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLLCTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRDKSAKRPAKDAPKKAAVKEAAPVKASFRRERALIKRGIWPVAGCDEAGRGPLAGPVVAAAVILDPDRIPRGIDDSKRLTAEQREKLFDKICATAQVSVAVASPARIDRDNILRASLWALKRAVVALPEAPRHVFVDGRDRLDTACDCEAVIGGDGIVLSIAAASIVAKVTRDRLMCALAQDCPGYGFEQHKGYGVPEHLDALNRLGPTVHHRSFFAPVAAARAKHMPWTVEPVRDLFAATEVEVQLEASVEIDASANL
The following text describes a protein:
Function:
Is probably involved in a pathway contributing to genomic integrity.
Miscellaneous:
MISCELLANEOUS: Present with 7110 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRFSMLIGFNLLTALSSFCAAISANNSDNVEHEQEVAEAVAPPSINIEVKYDVVGKESENHDSFLEFYAEDTATLAYNVTNWEDTNITIFGVNGTIVTYPHGYPVADITGASIGPYEMEVNGTSKFGQDVTLNLPEGQYFLIPFLLASRFDEIVRIAAPPTLFEIVSPPISFFNPQFLSVQVIFLAIIGGVSYYYMKSKTNQRPSKKSATVKKVDESWLPETYKK
The following text describes a protein:
Function:
Putative zinc aminopeptidase which may be involved in ribosome biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 5110 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDNLLSLENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAHATIGSTKFDLKISQDTGKHLSIFNSESPIQLSNDCPLILSVQYVGKIRDIKTHHDKTFGIFKTNFMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPVEMVEALDSSQKHLVKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIYAPWDIANAAFTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIPPNALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWTSEPYLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLESVFEDTKTFHARSVKPMDIWNHIGKFLKSQNITNFVSSWTRTPGLPVVKVEVEEKDGKTQTKLTQHRFINQLSTEEKDQLEDVPYQVPLFGVLPDGKMDTKNVLLTDRTLKFDYPILVINHLAQGYYRVSYESEECYALINDKITEETLSEIDLRKIFLDLSQFIGDEGFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGLEVLQTIDRASLTSSKLQSFLKKKIVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQGPRSSVPLELVNSILVVVSQHCANIKQWKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCLDSDIVKKTLNFITSNIESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKATRKGTTTGDHLHKALRSISLIIFQMFVADEPQKIEKFINLEKEKLGQSLLSLDDIWASVQQDEESRKTIRRDLASLV
The following text describes a protein:
Function:
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes (By similarity). Involved in DNA repair of gamma-irradiation-mediated damages.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Domain:
The ADD domain predominantly interacts with histone H3 trimethylated at 'Lys-10'(H3K9me3) (and to a lesser extent H3 mono- or dimethylated at 'Lys-10') and simultaneously to histone H3 unmethylated at 'Lys-5' (H3K4me0). The interaction with H3K9me3 is disrupted by the presence of H3K4me3 suggesting a readout of the combined histone H3 methylation state.
Sequence:
MEANEESLKGKIEKLEGKEVIVESKEDEMDIIIEENREAEQEVMEVKARDGRGEQNDVLMEENNNQGEQKDEEMQDASSRSESSDFNSDEDEQILSRRDDELDLEKPLSEEEIDELISDLLAVESKAAEAQEALEKESLSKVESEVREELAQALRGDELDEAVAAEMMTFKDEWEATLDELETESATLLEQLDGAGIELPKLYEMIESQAPNGCYTEAWKQRAHWVGTQVTKETVESLANAERFLHTHRPVRKRHGKLLEEGASGFLEKKLADGAVKESLAGTSELDWSSLNKVFSEKRDESVSFGSKQWASVYLASTPHQAAAMGLEFPGVNEVEEIEEIDASLADPFLADAIDNERELALTEEQKTNYIRVKEEDDITCDRVLQLRLKRKRRKKRSKQVIRCAAENMDDDSVYLDGNNTTPNFAKDQVKSPETSTQVHNSEVNIEENGNFSNSDVDKMTPSTHINVDAKRDDSQNPANNFRCTACNKVAVEVHSHPLLEVIVCMDCKRSIEDRVSKVDDSLERHCEWCGHIADLIDCRTCEKLFCASCIKRNIGEEYMSEAQSSGWDCCCCSPIPLQRLTLELEKAMRDKKSIELSSDSSSDSSSDNNSVDTDADVNVTISSKKKSKKKIRRIIDDAELGKDTRTKIAIEKARQERLRSLQFSARYKTISSMGDVKSIPEGAEVEVLGDAHSGYIVNVVREIGEEAVRVPRSISAKLKVHQVTGIRFMWENIIQSISRVKSGDKGLGCILAHTMGLGKTFQVIAFLYTAMRCVDLGLKTALIVTPVNVLHNWRSEFEKWMPSEVKPLRIFMLGDVSRERRFDLLTKWRKKGGVFLMGYTNFRNLSLGRGVKDLNAARGICNALRDGPDILVCDEAHIIKNTKADTTQALKQVKCQRRIALTGSPLQNNLMEYYCMVDFVREGFLGSSPEFRNRFQNPIENGQHMNSTAEDVKIMNQRSHILYEQLKGFVQRMDMNVVKKDLPPKTVFVISVKLSPLQRILYQRFLELYGFSDGRTDERMRKNFFAAYQVLAQILNHPGIPQLRSEDSKNGRRGSIVDIPDDCSSDENIDYNMVTGEKQRTMNDLQDKVDGYLQKDWWVDLLQKNNYKVSDFSGKMILLLDILSMSADVGDKALVFSQSIPTLDLIELYLSRVPRHGKQGKFWKKGKDWYRIDGKTESSERQKLVDRFNEPDNKRVKCTLISTRAGSLGINLYAANRVIIVDGSWNPTYDLQAIFRAWRYGQKKPVFAYRLMARGTIEEKIYKRQVTKEGLAARVVDRQQVHRTISKEEMLHLFEFDDDDEKSEAVTEISKQNEAGHSNLVEQAILWTKKATLSRVGGDKLMENLLQRHGPNWISSFHEHETLLQENEEERLTKEEKDMAWEVYRRALEWEEVQRVPFSESPVVPKPSPSTQTEPLPQPKGFNRSRFVNRNCTRIAHQLTLISQGLKVGSSTVCGECGRVIRWEDVIPASKLSAVIVN
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Sequence:
MEKRCEPDTFIDSIKRKRKIQKQWVYEDGKIVHRKISYVPGLYNIFDIILVHAADKKRRDPSMNRLRVKIDTKMNEISVYHNGAPLIGDETFDDVINNFDLTNSYSTCFWVELADECGISRQEFSNNMDVKFERVVCKVDDYSTMVTFKPDLTKFEMTCLEEDVVALMKKRVLDMAGCLGDTVTVELISEVIPFNSFKGYADFFLNCAQESTPFPLPRTHAKLSDSLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITKQITTYIKKEVLKMKEHVNVNADTVKNRLWVFVNARIDNPTFHSQTKEMLTTKPARLGLNSRLTHGQKSEIAKTLLPRIRICLKRTHVETHVEAMLAGGSERGKCTLILTHGEFAFAMAGVSAWLDPDLYGVFPLSSKLLNVRDSRKLLKKKEIQILMTILGLVRNKKYSDAESLRYGRLMIMANQDEDGAYLKGLLINFIYSFWPSLLKVSKFMSVFTIPIIKASNSKEGKELSFDSMQQYEDWEKDLGNTSTDDWEIEYCKGFTAAQEVKEYFQDLGERRAYFVWDDDDEQDGTSTSIELAFSKKAEEWKAWVCNSQMMQPGTCNYESKSIKYRDFVNKELLFFSMKNLQRFIPSMVDGLTLGQRKTLFCSFKMKLTKPTEVFRLTTYVALHSFFHDDEQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRELGGKDHASFRKLCNKLNCVTRLLFPVDDDKLLEYLNEDGKSVEPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPCEIIENVRRFLNKEEMVPMKPWYRGFRGTIKKSAKGYTINGLVERINEQTSFRQIGVYEMVDFKVKMKPEKIATTEDEDKEELRRKFNLTCTISTSNMYLFDAEGKIMKYNSPEQILEEFCRLRQEYYVKRKEYLVKNFKQLLRSLKMKQTFITNVVYASCRIYRRAEFLTEILKKVKSSEPQVAGAIDYGSEEQKADEQETVATLGDYKYLSSLPLESFTRESLVKLEAELGEKKKELKTLKDTSPDSMWLNDLMLFEKEFDKLQKIQTEEERNRSIMLKRKNDFAIDAKKLSQPRKNNQKEADDDIPSLACHVELSGEKTRDSDNAVVDADDLVQEKASPAKKGPTKAATTSKRKNVQPAESAGRKKVRKTRESPFNEVVRNLEYMSDSDPDGDNDSDDEHLSGFMH
The following text describes a protein:
Function:
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
Sequence:
MESDNKLFLLDAYALIYRAYYAFIKNPRINSKGFNTSAILGFVNTLEEVLKKENPSHIGVAFDPSGPTFRHEAFEQYKAQREETPEAIRLSVPIIKDIIHAYRIPILEVAGYEADDVIGTLATEAGRQGITTYMMTPDKDYGQLVTDNVFMYRPKHTGGFEVMGIEEVKAKFDIQSPAQVIDMLGLMGDASDNIPGCPGVGEKTAQKLIAEFGSIENLLEHTDQLKGALKTKVETNKELITFSKFLATIKIDVPIQLEMDKLVREQADEDSLRQIFEELEFRTLIDRVLKKENSAGGVTMATGSKTATAKSAPSPLPLFPEEGGAIQGDLFANFTGNEAGEAKKSNLETLETLNCDYQLIDTEKKRAEIIQKLLTSKILSLDTETTGTEPMDAELVGMSFSITENQAFYVPVPDNREEALKIVNEFRPVFENENSLKVGQNIKYDMIVLENYGVQVKGALFDTMIAHYVLQPELRHGMDYLAEIYLHYQTIHIDELIGPKGKNQKNMRDLDPKDIYRYACEDADVTLKLKNVLEKELKENDAERLFYDIEMPLVPVLVNIERNGVLLDTEALKQSSVHFTAQMQRIEQEIYELAGETFNIASPKQVGEVLFDKLRIIEKAKKTKTGQYVTSEEVLESLRHKHPVVEKILEHRGLKKLLGTYIDALPQLINPRTGRVHTSFNQTVTSTGRLSSSNPNLQNIPIRDENGKEIRKAFIPDEGCLFFSADYSQIELRIMAHLSEDKNMIDAFLSNHDIHAATAAKIYKIDLKDVDSDMRRKAKTANFGIIYGISVFGLAERMNVDRKEAKELIDGYFETYPSVKAYMEKSIQIAQEKGYVETIFHRKRFLPDINSRNAVVRGYAERNAINAPIQGSAADIIKVAMARIYQRFQTEGIQAKMILQVHDELNFSVPVNEKERVEEIVIEEMEHAYRMHVPLKADCGWGKNWLEAH
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MNPTTFIISFMIALSGLAFYQTHLLSLFLCLEGMALSVFCLMAISSSYTLSLSTIPLPLIMLTFSVCEAGLSLVLLVTMTRTHQNDLMSSLTLLKC
The following text describes a protein:
Function:
Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation. The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins. The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin. The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis. The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins. During replication, the complex helps prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2. The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination. It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57. Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci. Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets.
Subcellular Localization:
Nucleus. Chromosome. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes to few distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots).
Domain:
The region between Ser-201 and Leu-335 is required recruitment of SLX5 to ub-hotspots via interaction with EUC1.
Sequence:
MHSDTNGRTKSNNSPSDNNPNETVILIDSDKEEDASIREANLPVRLYPDRRVGRRRDALNRFVRSDSRSRNSQRTHITASSERPDFQANNDDITIIREVGRFFGDDGPIDPSAHYVDLDQEPGSETLETPRTIQVDNTNGYLNDNGNNNESDDGLTIVEERTTRPRVTLNLPGGERLEVTATTTDIPIRRSFEFQEDLGASRRQLLRRSATRARNLFVDRSDENDEDWTDDTHNLPEAIQRARRESRMRMSRRIAERQRRVQQQRVSSDENISTSIRLQSIRERIQSYTPDIRSAFHRAESLHEFRSILQNVAPITLQECEEELMALFTEFRNQLLQNWAIDRVRNTQEEALRLHREALERQERTAGRVFHRGTLRESITNYLNFNGEDGFLSRLWSGPALSDADEERHTQNIIDMIQEREERERDVVMKNLMNKTRAQQEEFEARAASLPEGYSASFDTTPKMKLDITKNGKEETIIVTDDDLAKTLEDIPVCCLCGAELGVGIPDDFTGISQKDRGVSFEGLVSKYKFHCPYQTLARPSMLDRDLSKRTFIASCGHAFCGRCFARIDNAKKKSKMPKKKLAQLKGSAHPDNYGPKLCPADSCKKLIRSRGRLKEVYF
The following text describes a protein:
Function:
Catalyzes the reversible conversion of L-glutamate to 2-oxoglutarate.
Sequence:
MTIDPGAKQDVEAWTTFTASADIPDWISKAYIDSYRGPRDDSSEATKAAEASWLPASLLTPAMLGAHYRLGRHRAAGESCVAVYRADDPAGFGPALQVVAEHGGMLMDSVTVLLHRLGIAYAAILTPVFDVHRSPTGELLRIEPKAEGTSPHLGEAWMHVALSPAVDHKGLAEVERLLPKVLADVQRVATDATALIATLSELAGEVESNAGGRFSAPDRQDVGELLRWLGDGNFLLLGYQRCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKLLVLAQARVGSYLRYGAYPYAIAVREYVDGSVVEHRFVGLFSVAAMNADVLEIPTISRRVREALAMAESDPSHPGQLLLDVIQTVPRPELFTLSAQRLLTMARAVVDLGSQRQALLFLRADRLQYFVSCLVYMPRDRYTTAVRMQFEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEVGVAGEGAAAPPVDVSEANRIRIQGLLTEAARTWADRLIGAAAAAGSVGQADAMHYAAAFSEAYKQAVTPADAIGDIAVITELTDDSVKLVFSERDEQGVAQLTWFLGGRTASLSQLLPMLQSMGVVVLEERPFSVTRPDGLPVWIYQFKISPHPTIPLAPTVAERAATAHRFAEAVTAIWHGRVEIDRFNELVMRAGLTWQQVVLLRAYAKYLRQAGFPYSQSYIESVLNEHPATVRSLVDLFEALFVPVPSGSASNRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTRQGSARCRDVLALKLNAQLIDELPLPRPRYEIFVYSPRVEGVHLRFGPVARGGLRWSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLPTGDPAADRDATRAEGVACYQLFISGLLDVTDNVDHATASVNPPPEVVRRDGDDAYLVVAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAWEAVKRHFREIGIDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDHRHIFLDPNPDAAVSWAERRRMFELPRSSWSDYDRSLISEGGGVYSREQKAIPLSAQVRAVLGIDGSVDGGAAEMAPPNLIRAILRAPVDLLFNGGIGTYIKAESESDADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSGGRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGTVKADERTQLLESMTDEVAQLVLADNEDQNDLMGTSRANAASLLPVHAMQIKYLVAERGVNRELEALPSEKEIARRSEAGIGLTSPELATLMAHVKLGLKEEVLATELPDQDVFASRLPRYFPTALRERFTPEIRSHQLRREIVTTMLINDLVDTAGITYAFRIAEDVGVTPIDAVRTYVATDAIFGVGHIWRRIRAANLPIALSDRLTLDTRRLIDRAGRWLLNYRPQPLAVGAEINRFAAMVKALTPRMSEWLRGDDKAIVEKTAAEFASQGVPEDLAYRVSTGLYRYSLLDIIDIADIADIDAAEVADTYFALMDRLGTDGLLTAVSQLPRHDRWHSLARLAIRDDIYGALRSLCFDVLAVGEPGESSEQKIAEWEHLSASRVARARRTLDDIRASGQKDLATLSVAARQIRRMTRTSGRGISG
The following text describes a protein:
Function:
GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast.
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein.
Sequence:
MEDNVAENNDSATEEGENQCVEVVDSAAIADETENLNDGNEKLDESTVGVISNEVSHIEDSDSATEDGKSRNTEIVDLAAIGDETSNLNDEHEKLDESIQNPVNVISDQVSHFEDRVADNGDSAIDDVKNQHVESVNSSVSHIEDRVADNGDSAIDDGKNQHVESVDSSVSHIENRVADNGDSAIDDGKNQHVQSVDSSVIVDETLNLNDENEMFDESVQNPVNVILDKASRVEDSVAEDSDSAIEDGKLHNKETVDSTAVADETASPDDENEKLDEPNEKPVGVISNKMSYAEALTSGDVKIVDADNKEALISEMPKTQESNELSRDVTEPEKLDIETEHHEITENQDCNKVNGGEIESNLPENGSLDHVSMVGTLNHEDMPSVDSDALKEQVQEDTDVHEKHENHSADLSEVQKDEVMELEENSREADDSRDIDHEENSGIAAAETSKLGSNLQTAFEDSTPKPEIAETPRSSQPQLVDSSSEVSTNIVENVAKVQEPVTHGTTPKLEQEIKPVTAISSAANSTTPPPAGLGNTAPLLDHGSQNKDRWSRTVADNIPSTNITSATPARPAGLGRAAPLLEPTSRAVQQPRVNGAVSAAQNQLIEDPTNGESEEYDETREKLQMIRVKFLRLAHRLGQTPHNVVVAQVLYRLGLAEQLHGRSGGRVAGFSFDRASAMAEQLEAAGQDPLDFTCTIMVLGKSGVGKSATINSIFDEVMFGTDAFQLGTKKVQDIVGTVQGIRVRVIDTPGLFPSWSDQRQNEKILHSVKRFIKKTPPDIVLYLDRLDMQSRDMGDMPLLRTITDIFGQSIWFNAIVVLTHAASAPPEGPNGTTTSYDMFVTQRSHVVQQAIRQAAGDMRLMNPVSLVENHSACRTNRAGQRVLPNGQVWKPHLLLLSFASKILAEANTLLKLADSPPGRPFAPRTRSPPLPSLLPSLLQSRPEVKLPSEQFGDDDDAVDDDLDECSDSEGESEYDALPPFRSLTKAQLENLSKQQKKAYYDELEYREKLFMKKQLKEERKRRKMMKKMQEAAIGLPADYGDNGEEEASAAASVPVPMPDLALPASFDSDNPTHRYRSLDSSNPWLVRAVLEPNGWDHDIGYDGINVERLFVLDSNVPVSFSGHISKDKKDASLQMEMATSVKHGKGKATTLGFDMQPFGKDYAYTLRSDTRFISNRVNKAAAGLSTTVLGDILTGGVKLEDKLTIGKRGQLLVSGGAIYGRGEVAYGGSLEATLRDKEHPLGRFLSTLGISVMDWHGDLAVGCNSQTQIPIGRHTNLIGRFNLNNRGSGQLSLKVNSSEQLQIVLIGLIPLVQKVLGYSQQVQYG
The following text describes a protein:
Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Sequence:
MGNNQPGGMYKRDRPFDSEKGGSKSRTGAPSASPPNEDECPVQMKIAKSDDKTKLFPVVFKWNQANTSARNVAICGSWDKWNQRIPLVKSSGDFSTIVDLEPGKHEYKFYVDHKWVVDDNQQKTSNHLGGENNVVMIDEADYEVFDALDKDLASSNAGEALRSNHPTKESHDTPNDRELEKLHQFGQETPTRADFGKAAPPPVLPPHLLQVILNKDTPVQCDPNVLPEPDHVMLNHLYALSIKDGVMVLSATHRYRKKFVTTLLYKPI
The following text describes a protein:
Function:
Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives.
Sequence:
MASRGVASYRTEVWSDWCPGCGDFGILAAMQKAFAELNLDPAQTVVVSGIGCSSKTPHFINVNGVHTIHGRGIAFATGIKLANPQLKVIVNGGDGDLLGIGVAHFVALGRRNLDVTVLIHNNKVYGLTKGQASPTLRRGEKVKSLPVPNLQDAVNPIALAIASGYTFVARAYSLWVDHLKEILKAAINHKGSAVIDVLQPCVTYNDIYTAEFYKDRLYKLEDDPSWDPIVRDPSEDEEKKAAAIKKAEEWGTRIPVGVFYVNPLKDTYEERLAQRNPSYSIDNPPALQPISREDGSPIVGPDEFRKIFKRFIVNVKKL
The following text describes a protein:
Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product.
Sequence:
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLSAAERAKKVEDMMKKLWGDRYFDPANGKFSKSANSPDGKKLPRTFCQLILDPIFKVFDAIMNFRKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGVVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKARARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL
The following text describes a protein:
Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDLNTTLSQNSTGDPSLQAWKQPLYVRYLLIIGYATVILLNVIGNPLVCLVVAKNKNMRNVTNLFITNVAVSDFLVGAICMPLALVDNLKAGWVFGEAMCTILPMIMGMTVTASVLTLVAIAVDRYLAVMRPTDDKISNKMTCIVIAAIWIAASVIMIPGAMMSEYKDADGHPTCHEKWSYVESKQAYSVSLFVFCYLIPLSAISGLYLRAGVRLYNRTVHRTPSPNDARHERGNQVHKLGNKARVFKMMVAVVVLFACLHLPMYIANLLNDLAPLGKPGRTVLYKYIYPIAHWLAHANSCMNPIVYAVLNRNFRQGFRHAFMPRRTRGVNVPKVTYKRAAVADQPDRVEVHCRLGQESPNDSRLQRPLPSPATLEAVNHDCSPGEPHFLHEVNQ
The following text describes a protein:
Function:
Acts as a transcription repressor.
Subcellular Localization:
Nucleus. Note=Colocalizes with ZBTB14 in nucleus in HEK293 cells.
Sequence:
MEGLLHYINPAHAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTNKENESQTVFQLDFCEPDAFDNVLNYIYSSSLFVEKSSLAAVQELGYSLGISFLTNIVSKTPQAPFPTCPNRKKVFVEDDENSSQKRSVIVCQSRNEAQGKTVSQNQPDVSHTSRPSPSIAVKANTNKPHVPKPIEPLHNLSLTEKSWPKDSSVVYAKSLEHSGSLDDPNRISLVKRNAVLPSKPLQDREAMDDKPGVSGQLPKGKALELALKRPRPPVLSVCSSSETPYLLKETNKGNGQGEDRNLLYYSKLGLVIPSSGSGSGNQSIDRSGPLVKSLLRRSLSMDSQVPVYSPSIDLKSSQGSSSVSSDAPGNVLCALSQKSSLKDCSEKTALDDRPQVLQPHRLRSFSASQSTDREGASPVTEVRIKTEPSSPLSDPSDIIRVTVGDAATTAAASSSSVTRDLSLKTEDDQKDMSRLPAKRRFQADRRLPFKKLKVNEHGSPVSEDNFEEGSSPTLLDADFPDSDLNKDEFGELEGTRPNKKFKCKHCLKIFRSTAGLHRHVNMYHNPEKPYACDICHKRFHTNFKVWTHCQTQHGIVKNPSPASSSHAVLDEKFQRKLIDIVREREIKKALIIKLRRGKPGFQGQSSSQAQQVIKRNLRSRAKGAYICTYCGKAYRFLSQFKQHIKMHPGEKPLGVNKVAKPKEHAPLASPVENKEVYQCRLCNAKLSSLLEQGSHERLCRNAAVCPYCSLRFFSPELKQEHESKCEYKKLTCLECMRTFKSSFSIWRHQVEVHNQNNMAPTENFSLPVLDHNGDVTGSSRPQSQPEPNKVNHIVTTKDDNVFSDSSEQVNFDSEDSSCLPEDLSLSKQLKIQVKEEPVEEAEEEAPEASTAPKEAGPSKEASLWPCEKCGKMFTVHKQLERHQELLCSVKPFICHVCNKAFRTNFRLWSHFQSHMSQASEESAHKESEVCPVPTNSPSPPPLPPPPPLPKIQPLEPDSPTGLSENPTPATEKLFVPQESDTLFYHAPPLSAITFKRQFMCKLCHRTFKTAFSLWSHEQTHN