lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MVSRFYQIPGTHRPSSAISSSNESSSLLSARRISQTYFNYQATPECQKVSSKYDPDNPNKDKLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAISTNGTVRGGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLLYNLGYSAQGEPPAALGELLPRGHWHEFTYATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFSIPLSALIRSPFTEGGISYTGPSWQTFHDNLLPHLTKGAAGSLLKGKETFNDLFGVFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLFTFICYAVVVFSMGCSIPRRSLYDEVQIIQTISSVQWVIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFAHSPLYSLIFTWILTQLCLFSDVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLSVVAMLIVDGISASVLFLAMILLFLFIHYFSPPKSWGDVSQSLIYHQVRKYLLRLRQDNIKYWRPQILLFVDNPRTSWNLIRFCNHLKKGGLYILGHVAVTADFPKQLNELKTQQKAWMKIRDMAAIKAFVQVGTGPSLIWGIRNVFIGSGLGGMKPNITVVGFFDLESYRKHIPQSRSQNNLQKQVEIKATVPRSTCSDVKINVPLPTDECKNETKVNVQQWVQIVEDLSLMQSNIAIAHGFKNLEIPNKRDSCFPKKTIDLYPIQMCGKVEAKGDQPAAITTNFDTYTLILQLAAILVTVPEWKRTHSLRVILFVEQEYHRTNETQRMKKLLQVLRIDAEVLVVSLDQFRVYNTIVKGDPIVFDYVNSKLADNEWWKDLVEARDTLKPKRRFSTIEPQTIAKQFTQSRKYTSGVQKLGVSFTMNTRMPTNRIDTPCESEDSDLDTDLTSIRDAFSASTNISVGKDLTTKSKTGSDRTNLLVKNLQSDVSTQSLRPVFSSNTLPRTRVVEDGTGEQPTLIPIAEPDLSNGNGTGSGIGNGNKLKKPVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQHLVLNDVMTQMSKSSDLIFSTLPVPALGTHEDHDASLQYVEDLDIWLEGLPPCMLINSQTMTVTTAL
The following text describes a protein:
Function:
Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
Miscellaneous:
MISCELLANEOUS: LasR in strain PA103 is not active, this is probably due to the change in position 180 of the sequence.
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
The following text describes a protein:
Function:
Retinoid-binding protein which shows highest affinity for all-trans retinol. Can also bind all-trans forms of retinoic acid and retinal, but has lower affinity for cis form retinoids. Required in retinal pigment cells for rhodopsin biosynthesis.
Sequence:
MWSRSSSSKRQVATTDGDPERVLAQVQDLSDWLVANPQINGCNTFENLHFFLRTSKFDVERAKKKLKTFYQMRAERTEWFDNRDPQLPEIQDLLKLGVFLPIGPDAEQRMVVVIRTAAHDPKLHSQNNVFKTSKMILDLLLKLDPETCARGMVAILDMQGVQLGHALQMNPKLIKRSVESWTAYPCQPKLLEFTNAPRHVNFFLNTFRIFMTPKIRSRLFVRREGTSVSCDQLPKELGGQGLSYMELSVKWKQLVEENADFYVEQDKYKSKLK
The following text describes a protein:
Function:
Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Secreted, extracellular exosome.
Sequence:
MDKLLAALCLLGMCCSLAVTDVSVRSSPLDLEASGDDEDFSGSGIDDLDVDHVVPSTSALPSVLSAVPNFVQENTSPNAKVDEKDTAAEHTTRVVETTKPSEDPVEELVEPVFVGVGHDAESTSPEATTHKPTTHRPTTVKSTAGPMESITEQNHHPHHHHHHHHHHHQNHTTTAKPTSATDQHVDNSDSPSGEDKSYIHHKVTTTSPIDNEEPDLHEADHRLTTIKPRNTEELINHHVPDQDSPSGSSSTPYMEFEETTEDPSGARVHNVLIGHDEKTTTKPSENEEGDGMFAGHHEKPTTTSPSNEEGSHIQHDTTTSSPSHHAEPDVEVHHSTTPADMNKHHHHHHHHPHHHTTPEAITSVDEEIPHHVGDSTTPSDLNKHHHHHHPHHHTTSETTTSVDEVPHHVDDSTTPSDLNKHHHHHHPHHHTTPETTKTTTSQTKHSAEVSTVVHKGRMAHGASATSAVPALDDLVDLTTSVVLEEGDSDPADSKEDESSGEKEEDNFFFVNREVIQKGTAPPIHRMINNDVSDNESTSDASHGIMERKEVLAGIIAGGVAGLAFAVFLVGFMLYRMKKKDEGSYSLEEPKQSNGGYQKPRAQREFYA
The following text describes a protein:
Function:
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains. Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular Localization:
Secreted. Cell membrane.
Sequence:
MRLLAQLLGLLMLWVPGSSGDIVMTQTPLSSPVTLGQPASISFRSSQSLVHSDGNTYLSWLQQRPGQPPRLLIYKVSNRFSGVPDRFSGSGAGTDFTLKISRVEAEDVGVYYCTQATQFP
The following text describes a protein:
Function:
Plays an essential role in the viral lytic DNA replication by acting as the polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template (By similarity).
Subcellular Localization:
Virion tegument. Host nucleus.
Sequence:
MPVDFHYGVRVDVTLLSKIRRVNEHIKSATKTGVVQVHGSACTPTLSVLSSVGTAGVLGLRIKNALTPLVGHTEGSGDVSFSFRNTSVGSGFTHTRELFGANVLDAGIAFYRKGEACDTGAQPQFVRTTISYGDNLTSTVHKSVVDQKGILPFHDRMEAGGRTTRLLLCGKTGAFLLKWLRQQKTKEDQTVTVSVSETLSIVTFSLGGVSKIIDFKPETKPVSGWDGLKGKKSVDVGVVHTDALSRVSLESLIAALRLCKVPGWFTPGLIWHSNEILEVEGVPTGCQSGDVKLSVLLLEVNRSVSAEGGESSQKVPDSIPDSRRQPELESPDSPPLTPVGPFGPLEDASEDAASVTSCPPAAPTKDSTKRPHKRRSDSSQSRDRGKVPKTTFNPLI
The following text describes a protein:
Function:
Involved in pollen wall development. Catalyzes the conversion of long-chain fatty acids to the corresponding omega-hydroxylated fatty acids. Omega-hydroxylated fatty acids, together with in-chain hydroxylated fatty acids, are key monomeric aliphatic building blocks for sporopollenin synthesis during exine formation.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSLCLVIACMVTSWIFLHRWGQRNKSGPKTWPLVGAAIEQLTNFDRMHDWLVEYLYNSRTVVVPMPFTTYTYIADPINVEYVLKTNFSNYPKGETYHSYMEVLLGDGIFNSDGELWRKQRKTASFEFASKNLRDFSTVVFKEYSLKLFTILSQASFKEQQVDMQELLMRMTLDSICKVGFGVEIGTLAPELPENHFAKAFDTANIIVTLRFIDPLWKMKKFLNIGSEALLGKSIKVVNDFTYSVIRRRKAELLEAQISPTNNNNNNNNKVKHDILSRFIEISDDPDSKETEKSLRDIVLNFVIAGRDTTATTLTWAIYMIMMNENVAEKLYSELQELEKESAEATNTSLHQYDTEDFNSFNEKVTEFAGLLNYDSLGKLHYLHAVITETLRLYPAVPQDPKGVLEDDMLPNGTKVKAGGMVTYVPYSMGRMEYNWGSDAALFKPERWLKDGVFQNASPFKFTAFQAGPRICLGKDSAYLQMKMAMAILCRFYKFHLVPNHPVKYRMMTILSMAHGLKVTVSRRS
The following text describes a protein:
Function:
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions (By similarity). Functions, in conjunction with MutT, to protect vegetatively growing cells from DNA-damaging agents such as H(2)O(2) or t-BHP (t-butylhydroperoxide). The 2 proteins do not however protect spores. According to PubMed:15576788, phosphohydrolase that catalyzes the hydrolysis of all common nucleoside triphosphates as well as of the mutagenic analog 8-oxo-dGTP. The high catalytic efficiency on dGTP is in contrast to results from PubMed:14761999. According to PubMed:14761999, catalyzes the hydrolysis of 8-oxo-dGTP with a specific activity 413 times higher than that exhibited against dGTP. Preferentially catalyzes the hydrolysis of 8-oxo-dGTP and 8-oxo-GTP. According to PubMed:15576788, hydrolyzes nucleoside triphosphates in a stepwise fashion through the diphosphate to the monophosphate, releasing two molecules of inorganic orthophosphate.
Miscellaneous:
MISCELLANEOUS: According to PubMed:14761999, can complement an E.coli mutT mutant. According to PubMed:15576788, cannot complement an E.coli mutT mutant.
Sequence:
MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHEDRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFADIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE
The following text describes a protein:
Function:
Low affinity, high-flux Na(+)-dependent bicarbonate transporter. Involved in carbone dioxide-concentrating mechanisms (CCMs) that accumulate CO(2) and improve photosynthetic carbon fixation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQITNKIHFRNLQGDLFGGVTAAVIALPMALAFGIASGAGATAGLWGAVIVGFFAALFGGTPTLISEPTGPMTVVQTAVIASLVAADPDNGLAMAFTVVMMAGLFQIAFGLLKLGKYVTMMPYTVISGFMSGIGIILVILQLAPFLGQASPKGGVIGTLQALPNLVSNVRPVETLLALMTVGIIWFMPSRWKKFAPPQLVALVLGTIISITLFGDLDIRRIGEIQAGLPALQLPVFQADQLQRMLIDAAVLGMLGCIDALLTSVVADSLTRTEHNSNKELVGQGIGNVMSGLFGGLGGAGATMGTVVNIQSGGRTALSGLIRAMVLLVVILGAAKLAATIPLAVLAGIAFKVGVDIIDWGFLKRAHHVSIKGALIMYAVIVLTVLVDLIAAVGIGVFIANILTIDRMSALQSKAVKSISDADDEILLSANEKRWLDEGNGRVLLFQLSGPMIFGVAKAIAREHNAIQECAAIVFDLSDVPHLGVTASLALENAIEEAAEKGRAVYIVGATGQTKRRLEKLQVFRFVPESNCYDDRSEALKDAVLALGPHESEDSPSSSSVQTTY
The following text describes a protein:
Function:
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTWKNNLTPVSEQFDDIYFSPENGLEETKHVFIKGNDLYNRWRNWNIQNAFCILELGFGTGLNFLTTWKEYLEYKDRFRLHFISIEKFPLNREEISKALSIFSELVEIKKEFLSSYQDLIPGMNYFQFLGGKIHFSLFLGDVSSALCEISGKVDAIFLDGFAPSKNPEMWDKSVLENLKYVSKKGTTLSTFTVARMVRDSLSFSGFKLEKRPGFGRKREMLIGSYSDSFLESNPKEKPWCKRAYPELQIKTVAIVGAGIAGTTLAYSLSRRGIQVFLIDPSGIAKETSGIPMAISHPHLTKIPGPISLFTLRAFRYALSFLSSFADQNFFEKTGLFHSVTQEMDSERLQKGIENHKLSEEIVFWKPIASKFQNGDFLENEPGVFFRNGFWTRPESIAKKCAEQPGVEFIKGTASRIEQDGTSWKLLIQESGHEIVANSIIFCNSHSIGKLIASLFEGEEPFPIRKVRGQLISLKETEKSSRISNILCAEHYLTPSILGEHILGSTFDEFDLNPLPQKKDTDRLLEFVQNKYPSLNFDSSCVLIEKVGLRAQTPDRLPILGPVFDPREFRKIYKEIDLPKNRNKKFPNLKTIQGLYVFGGLGSRGILSSFLGSEIMASLILGEPVPVESSVLEHLHPARFLYRKVRK
The following text describes a protein:
Function:
GRP proteins have a marked affinity for hydroxyapatite. They may play a role in the formation of the protective acquired pellicle at the saliva-tooth interface.
Subcellular Localization:
Secreted.
Sequence:
MLVVLLTAALLALSSAQGTDEEVNNAETSDVPADSEQQPVDSGSDPPSADADAENVQEGESAAPANEEPPATSGSEEEQQQQEPTQAENQEPPATSGSEEEQQQQEPTQAENQEPPATSGSEEEQQQQEPTQAEDQQPPATSGSEEEQQQQESTQAENQEPSDSAGEGQETQPEEGNVESPPSSPENSQEQPQQTNPEEKPPAPKTQEEPQHDSGRPKKPLLPFIANLIRERIRKLLARSPLGRRF
The following text describes a protein:
Function:
G-protein coupled receptor involved in the regulation of cell volume.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.
Sequence:
MFLVLERKMRTHQVFPLPLLLVIASVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKDKERKRPVCLHFLFLLGTLGLFGLTFAFIIQMDETICSIRRFLWGVLFALCFSCLLSQAWRVRRLVRQGTSPASWQLVSLALCLMLVQVIIATEWLVLTVLRDTKPACAYEPMDFVMALIYDMVLLAITLAQSLFTLCGKFKRWKVNGAFILVTTFLSALIWVVWMTMYLFGNSLIKQGDAWSDPTLAITLAASGWVFVIFHAIPEIHYTLLPPLQENPPNYFDTSQPRMRETAFDEEMHLPRAYMENKAFSMDEHNAALRSAVGFSNGSLEQRSSSLGKKPSSLGNRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHHW
The following text describes a protein:
Function:
Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKIRLLKPLLIVGVLLMIWQMVATLGSFPHYIFPSPQAVRQQLFTHAELLWQHTQVTLLEICLGLLLGFLFGLISALLLSFSRQISAVLLPILVISQAIPVFAIAPLLVLWFGYGMASKIVMSVLIIYFPVTAACYDGLRNTPQAWLDLAKTFNISPLRLLLKVRLPAALPAFASGLRIAVSVAPIGAVVGEWVGSSEGLGYLMIHANARMQVDLMFAALLILVSISLCLYFSIDWLLHRFIWSV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MKDYIYQNTLINKKQLKELLAWSFSKYDSMQASLLADELKYLGFKYATQAGISISIEDLKVPATKNEMLEKANKDILNAEKICLKGKITDVERFQKIIDTWSIASESLKDNVVSYFKTYDPLNSVYIMAFSGARGNLSQVRQLVGMRGLMADPSGEIMRVPIKKNFREGLTITDYLMSGYGARKGIVDTALKTANSGYLTRRLIDIAQDIVIREKDCLTSSSFLIDSQTKFDTEQLIGRVLLKSVYDSKTEKLIAKANTQLTLDLLNLFNQKQISKFYIRSPLTCNLYHSICQMCYGWDLSNQNLVDLGEAVGILAGQSIGEPGTQLTMRTFHTGGIFTSEARQQIISPKNGIIKFSKILKTIILRTNRGEDVLLTKNSGSLILIPEKHTDEIIQIELLRNTMLFVKSNQYIKQSAIIGELISTDKQTLTERKPILSDTAGEIFIPRLKTRMNLITQNRLLWILSGQVYQAPSNSFLNFYTDHKINKNSYIFRTKLINQYSGYTKVLNQNKNLLEQKIQITNETYFLENSYVQKILKPITNKNYLLNFNNLTYLITLKDSNSKNWKRCKKYKPFATSFNNNFKTLTGGIMYYDQRIKQKFDSFNTLISYNIAYEISKEDYDKVSKDHYENYLKKLENKIDKNGFIFYQNFLNYQEMESIFLKFKLKKKIVHNSLIWLSEETYKLNCDKNILLVENGNFIAKNFEIIPNIISKTAGIITVSQKNNMIEEIAIKAGFVYQGKQFEQLDKKVYYPGEIIFDNIKITQPSLCEHINNKSNNQLLIRPFAIYEIPKEKTVKSLFSDKNNSKSIFTITNKITYLYKTNQKIKTSNHINLISQNINLKAKNSVQNNTIIDLSNSFKTKRLNLRISENLLLKHYIPAHLKYTNLQYCLLVEPTQFIDSYTTLGYLESLITNSLEIVKFKSKRANKKQVFLISNKDCITVRKEQGKNKTANELIIDNINVNQTGKVLIDNGQFLTVQKGRPYFFPNCKSDDSKEKLDLQYKLIGLNNTISNNTNTFLNYYDVTKRSLVERLGPNKKSYGFKVKFSKMFIKKNGKFYSSPIPLFLNNFSIIKEEQKRLNEGKNEINNFIIKNTQLKIKQCLPLLLKSSELVTNKIKRKTPFNNNLTGLKFLKYPFNKSIGIHSLTEDYFEQEVNNVYCKNGEFIEKGEVIGLLNFEKEITGDIVQGLPRIEELLEARKKKPTNKHLATNQKKSLLIQKTSIDSSFEFQKLGTTIKENDKINPHNLLKIYFNYYGIKKQFFSNKEMFALSYRLTDNYEASYRTFKKIQLLILNAVQSVYESQGVSIANKHLEVIIKQMTTKVLITHEGHTPLLPREVVDLYHIQYINKIIEAHNKRPAYYVPLLLGITKAALNNPSFISAASFQETTRVLTKAAIEGRVDWLRGLKENIIIGHLIPSGTGYQSYSNCFNQLAQSKTKINLEKIKIKI
The following text describes a protein:
Function:
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA.
Miscellaneous:
MISCELLANEOUS: Depletion of GRSF1 by siRNA results in a combined OXPHOS assembly defect, with the prominent loss of complexes I, III, IV, and V. It also leads to altered steady-state levels of mitochondrial rRNAs and mRNAs.
Subcellular Localization:
[Isoform 1]: Mitochondrion matrix. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids; [Isoform 2]: Cytoplasm.
Domain:
The RRM domains mediate RNA-binding.
Sequence:
MAGTRWVLGALLRGCGCNCSSCRRTGAACLPFYSAAGSIPSGVSGRRRLLLLLGAAAAAASQTRGLQTGPVPPGRLAGPPAVATSAAAAAAASYSALRASLLPQSLAAAAAVPTRSYSQESKTTYLEDLPPPPEYELAPSKLEEEVDDVFLIRAQGLPWSCTMEDVLNFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLQVKSSPVVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIEIFPSRRNEVRTHVGSYKGKKIASFPTAKYITEPEMVFEEHEVNEDIQPMTAFESEKEIELPKEVPEKLPEAADFGTTSSLHFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFETHEDAVAAMLKDRSHVHHRYIELFLNSCPKGK
The following text describes a protein:
Function:
Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MADNDGPRGDNGSSNRDRKRKWEDRGGGKRGGRGGRSLQHGSRPDKKRNMGRKEHKTAQLDRRGRNAEQQDKNKDHEEKGENEKPALPAAFPAEEVEAEERRPKRKVAVMIGYSGTGYKGMQIDNKQKTIEGDLFTAFVAAGAISKANADDPKKSSLVRCARTDKGVHAAGNVISLKLIIEEEDIVEKINSHLSEQIRVWGIQRTTGSFSCYQACDSRWYEYLIPTHAFLPPHPSSFLGKKLEEYAEKEGDMDAYRARQAEVANFWAETEEKYIKPILDSLDDSIRPLVQDALYTQDSVDAPPGDPLIDASIDTAGTEPAPPKEEAAEETAKPDAGEPMNVDKPEDEVKDMVDAIQQQEPNLTLDSETDGSVPLPSKTVHVSPLEEAVKALKAAYLSAKKSYRISPERQARVQAALNNYLGTRKYHNYTVQKKFSDKSAQRYIKSFKVAPKPIIINDTEWLSLKVHGQSFMMHQIRKMVGMVALTVRCGSNPDIMIESFGNTIVRIPKAPGLGLLLERPVFDSYNEKSAKQAGREKVDFNKYNDKIEEFKEREIYQRIFREEAQGNQFNAFFTHLDNYKDPQFLYLTSGGVEATKKSLGNKSAQAKYEEDSEDENASGGEG
The following text describes a protein:
Function:
Part of the ABC transporter complex FhuCBGD involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of ferrichrome and coprogen.
Subcellular Localization:
Cell membrane; Lipid-anchor. Membrane raft; Lipid-anchor. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Sequence:
MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFTYKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENIGDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTGTEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYKDLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWKNLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK
The following text describes a protein:
Function:
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity).
Subcellular Localization:
Nucleus. Golgi apparatus, trans-Golgi network.
Sequence:
MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN
The following text describes a protein:
Function:
Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Can also use 3,17-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one (3,17-DHSA), but it has higher specificity for 3-HSA than for 3,17-DHSA. Can use either FADH(2) or FMNH(2) as flavin cosubstrate. Also catalyzes the o-hydroxylation of a range of p-substituted phenols to generate the corresponding catechols.
Miscellaneous:
MISCELLANEOUS: Cholesterol metabolism contributes to the survival of M.tuberculosis in the host by helping the bacterial multiplication during earlier stages of infection and to the dissemination of the pathogen in the host.
Sequence:
MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQRAQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRPVDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPGDTMV
The following text describes a protein:
Function:
The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba1 may act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression.
Subcellular Localization:
Nucleus.
Domain:
The BEN domain mediates DNA-binding.
Sequence:
MINRRQRLEFALTLLPYDPETVQLSETQKKVEAIIARLRTDDSFTEEESDDCKVRRIQDANEFADSAMRHIEMSDSGKLSTLETLTLAAEKLLRTQRSPDQDFDDMVQDVEYSQLMRNTIQAVNEARLKLLQQWERSKRKALDLLTIEIEKVQEMDQEPEHKQSHEQDQDQEQSSEPFNAFRDGADEHNTSTPKTNDEDLGLDDDDEDYVPGGEETMGNKRKRIKKPVTSTPNAKRRCPGFEFDLDGESPMVTIGPNGTEVSRISLSAINWDMTGPSITRKLLCEIFDRDTLAHHTLSGKPSPAFRDCARPSKQQLDPLKVADLVYLMTNSLDMTPREVRTAITTKCADENKMLRSRMQRKSK
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MVNDIIADSLTRLRNASMRRLEFTQLYYAKIVVSILEIFKEKGFIKDFNVKDKDKKQSVYVQLAYDEKGHSKISEVKRLSKPGRRVYKQKNELKRFKNGYGVIVVSTSKGVITNEEAYRQNVGGEVLCSIW
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Sequence:
MSISENIKRITTEIRQAEKEFSRSPNAVSLLAVSKSQSLDKIKEAIAAGQRQFGENYLQEALVKIKALRAHPLEWHFIGVIQTNKTRLISTNFDWVQSVSRLEVASELHHYRPLELPPLSICIQVNISEEKTKSGVDLTNLSEFAKAVSQFDRLRLRGLMTIPAYQKDFNAQKATFEKLKEAQQQLIKKGLPLDVLSLGMTHDFRAAIAAGSTMVRIGTGIFGPREDR
The following text describes a protein:
Function:
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAKPHISCQFKRDYPQLINLYPTCTIATQHSLDNLNRLRHQCLTALLTQPSPHLCVMGQWGLGDGIELLSFIHYWQTLAKTQNLPRLLLKVFEPNPINYYELKLLWDQSQSLILHPHLQPIANAIIEAKPARIIGCQRLIFDDGRISLDLDFGDLQTMLVNQPHCGTYPIQQWLILPHLAPQLSRKILWQMARLSADDAHFIGVELAETTQNLAKTCGFSPLTITADMLCGEQIDSIASQIVTDDILLHERKLLRQQANNHQAFTPRPSQVASTKQPIAIIGGGLASAHLMLSLAEREQSSILFCKDNDLGQGASGNRQGAIYPLLTPENDELSRFFQQAFLFSRRRIAALSLASMKGSDVASGVMPISHDFCGVLQTGHDERSQQRLDKIIQSQDWPAEIAYAVDASEANKIAKIGIDKAGFYYPLGGWVCPFEYAKAAVDKASQLANVQCHFNTEITEIERDAKGWYLLSQDQRFGPFRQLVLANGAQLTQFSASERLQISPFRGQVSHIPSQFQLSQLATVLCANGYLTPSHQGLHCLGASYVKAAEHLDFCPLEQLENLGKMQQSYPNQDWVEDIDISANSARVGVRMVTRDHFPMMGCAPDVNEIWARYEQHQINQQQAEQIRHYWQTTPAPIHDGLYILGGLGSRGLSSGPLAAECLAAQLTDEPLPLDWPTLNKLSPNRMWLRKLLKGKAL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKEASLLACEGLAGVSLVPTAASKKMMLSQIASKQAENGERAGSPDVLRCSSQGHRKDSDKSRNRKDDDTLAEASHSKKTVKKVVVVEQNGSFQVKIPKNFICEHCFGAFRSSYHLKRHVLIHTGESAVFNTSLFTLVRNRLSVTYVICVSSRSTILNATSGYTVAKSLTSVNDVISVFLGQTDYSDTNGCAKDASPRLLMGSFLYRQEGP
The following text describes a protein:
Function:
Binds to centromeric K-type repeat DNA and ARS3002 DNA. The CBH-binding consensus sequence is Py-Pu-A-T-A-T-Py-Pu-T-A.
Subcellular Localization:
Nucleus. Chromosome, centromere.
Sequence:
MPPIRQAVSLAEKKAIRDYYNQSAHRIPQKEVTEWFRKTYNKDLSQSTISEILSPKYSYLDDGSVRLGDIKKIRAPKFPLLDNAVYEWLQQREVEGLPISGDMIKQAATRFWSKIPAYASLPLPDFSNGWLDKFRRRHYIQQSAVNQALESIKFEVFREYPVHIQEFIRPYAQKDIFCVGGTSLFWKLTPNKQNLDYQEIQGMKRGKAKVSLIMCCNADGSERLPLWIVGYAQNPRSFEQCGIFPKSMNFEWKWNGRASISPIIMEEWLRWFDTRMQGRKVLLMLESNDTYQFGVESVRRFKGGFQNTSVFRIPEKTLDIKSPFEQGIVDTFKANYRRYWLQYSLNQINILRDPLKAVNVLKAIRWMLWSWNFGVSEKTIQASFLRSGLLGPHSEAEGQGMESYQKAIMEIGNLISSKGSEAVKQINEYIRPSEEDETKLHQDAVDTVAAEFLEERRFESDEEEDVEPQISNVEAAMAFEVLIKYFEQHENGDPSFVLDLYRRQRVIAPNNLIA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSKRPVIESEKPAWHDEDDDNMVVAVPKKVKMTMRVELKRTTDEEHGELDSKEYVGRLQEAFRKRHGGTPKWAKAAAGDEEEGSLLKTAAGYLAKDVNLPKTTIHTTLIKDFNIGHRYTRGITVVKFHKTRPVLIVADQGGNVQLFKVSREVKKDRFLQSANFSKFPIDSLEIADKGHSVICSSSRKEYLMQYNMETREVTQLKPPNTVPKQGIRLFAISHDSQFLAIAGHNSHIYVLHATSMEHITTISLPANASEIKFFPSHSREIWIICETGQIVIANIGLPGTKSSQHTFTDDGAVHGTTLAISQHGDYFATGSDTGIVNVYSGNDCRNSTNPRPLFNVSNLVTAVSSIAFNSDAQLMAICSNVKDNHLRLVHVASQTTFKNFPERNGKVTHARCVEFSPNGGYMAVGNDDGRLHVFEIHHFTDY