lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells.
Sequence:
MSKSPDGGISEIETEEEPENLANSLDDSWRGVSMEAIHRNRQPFELENLPPVTAGNLHRVMYQLPIRETPPRPYKSPGKWDSEHVRLPCAPESKYPRENPDGSTTIDFRWEMIERALLQPIKTCEELQAAIISYNTTYRDQWHFRALHQLLDEELDESETRVFFEDLLPRIIRLALRLPDLIQSPVPLLKHHKNASLSLSQQQISCLLANAFLCTFPRRNTLKRKSEYSTFPDINFNRLYQSTGPAVLEKLKCIMHYFRRVCPTERDASNVPTGVVTFVRRSGLPEHLIDWSQSAAPLGDVPLHVDAEGTIEDEGIGLLQVDFANKYLGGGVLGHGCVQEEIRFVICPELLVGKLFTECLRPFEALVMLGAERYSNYTGYAGSFEWSGNFEDSTPRDSSGRRQTAIVAIDALHFAQSHHQYREDLMERELNKAYIGFVHWMVTPPPGVATGNWGCGAFGGDSYLKALLQLMVCAQLGRPLAYYTFGNVEFRDDFHEMWLLFRNDGTTVQQLWSILRSYSRLIKEKSSKEPRENKASKKKLYDFIKEELKKVRDVPGEGASAEAGSSRVAGLGEGKSETSAKSSPELNKQPARPQITITQQSTDLLPAQLSQDNSNSSEDQALLMLSDDEEANAMMEAASLEAKSSVEISNSSTTSKTSSTATKSMGSGGRQLSLLEMLDTHYEKGSASKRPRKSPNCSKAEGSAKSRKEIDVTDKDEKDDIVD
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MGTSYSSKLFSEFPQFVFDESDELAEMKSRWNPTESGKKKFRSGYSPVDNYTFLQSLAGGKERKGKKLRDETVIIHEDDDAVKERIVRSDTALQSSSSDYNSKSFAGSKSSDFITPKPLKAPTQRFCLADNEPVSLISDEDSDTSSEMSSNDLADTQGSSGEQSLVQEITSHEMEPSVVLHPKYTTYEGNCYWSAKLTFLPSSIKLNVSEEEAPMGPLTYEWKTVDLICIESKWLDPFPTADVCLHFKLEHPKQPISNQKSGIMKVNFTVCDPNWDSMQELIKSLDEQYKEKWEVDLDSYELFEDITYRGDCDCISISKRDFQLLHPEKFINDTIVDFYIEYLKKINPADERVHFFNSFFFRKLADFDENQLQMFDAKESFQRVRKWTKKVDIFQKDYIFIPVNFRLHWSLIIICHPGEVVSFEDEELEVSVKVPCILHMDSIKGSHRGIENCIKCYLWEEWKQRSSNRAEDISTKFKNLRFLRLEVPQQQNSYDCGLFMLHYMELFMKQAPSSFNPLSNFISKDWFFPTEASLKRGRIKRLIIELAKSRSEQVLSPNCNDEFSSEDKDVIEEESEDVEILNETCHGRSSTPLMVQPLRSEPYKSDCEESGDDEDSLIDDDEQNHGKLVLYDPSVAVLSPTKESKAKEEVDNEKKQVAIVSGKNESESFMTCLDKSLNLLQLKERNQPEEDVDVFVVEKKEDESDDDVFETCVVEDSDSDDSGRHLPLPCYRRKSASSSEGRIIRKNNVMSLQQQAPKRRHDVVSQAQKRLRRNSSADLQIISLCE
The following text describes a protein:
Function:
Involved in pollen tube guidance into micropyle. Participates in perception of the ovule-secreted peptide signal LURE1.
Subcellular Localization:
Cell membrane; Lipid-anchor. Cytoplasm. Note=In pollen tubes, mainly located in the plasma membrane to the tip region.
Sequence:
MIIMMNCFPCFTSQKSRNAPCTTNETNDDNVEHDEFRPPVVATTKRTEEREPAEQQPPVKTFNFRELATATKNFRQECLLGEGGFGRVYKGTLQSTGQLVAVKQLDKHGLHGNKEFLAEVLSLAKLEHPNLVKLIGYCADGDQRLLVFEYVSGGSLQDHLYEQKPGQKPMDWITRMKIAFGAAQGLDYLHDKVTPAVIYRDLKASNILLDAEFYPKLCDFGLHNLEPGTGDSLFLSSRVMDTYGYSAPEYTRGDDLTVKSDVYSFGVVLLELITGRRAIDTTKPNDEQNLVAWAQPIFKDPKRYPDMADPLLRKNFSERGLNQAVAITSMCLQEEPTARPLISDVMVALSFLSMSTEDGIPATVPMESFRDKSMSIALSRHGSCSVTPFCISRKDVGNKSSSSSDSEDEEEEKEQKAEKEEESTSKKRQEQEETATDSDDESDSNSEKDQEEEQSQLEKARESSSSSSDSGSERRSIDETNATAQSLKISYSNYSSEEEDNEKLSSKSSCKSNEESTFSRYDSGRDHDDSSRNTSMRINSLAHDDKEEDEEENHETRSYSDHDDSPRNTSMRINSLSHDDDEEEEEENHQTRLEHIHSSKSEDQSVYSDDDAGESGESSLHRIEAKEEEHISSDHD
The following text describes a protein:
Function:
Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides.
Sequence:
MKNTELEQLINEKLNSAAISDYAPNGLQVEGKETVQKIVTGVTASQALLDEAVRLGADAVIVHHGYFWKGESPVIRGMKRNRLKTLLANDINLYGWHLPLDAHPELGNNAQLAALLGITVMGEIEPLVPWGELTMPVPGLELASWIEARLGRKPLWCGDTGPEVVQRVAWCTGGGQSFIDSAARFGVDAFITGEVSEQTIHSAREQGLHFYAAGHHATERGGIRALSEWLNENTDLDVTFIDIPNPA
The following text describes a protein:
Function:
Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Also displays antifungal activity against C.albicans ATCC 2002. Has low hemolytic activity, low cytotoxicity and low antioxidant activity.
Subcellular Localization:
Secreted.
Sequence:
MFTLKKPLLLLFFLGTVSLSLCEQERAADDDEGEVIEEEVKRDSMGAVKLAKLLIDKMKCEVTKAC
The following text describes a protein:
Function:
Part of the dynein complex of respiratory cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MLPASAKAPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRRQHYRDELVAVSYQGSQESVKVISETGDLEEDEEPKELETEPGSQTDVPAAGAGEKVTEEELMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEKQEKTKEKEKAKTPVAKKSGKMAIRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQDFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQSRGMLLLYSLKNPSFPEYMFGSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHVDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNTSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSPNLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Subcellular Localization:
Cytoplasm.
Sequence:
MRKEIILASNSPRRIYLLGQIGIDFKVVSPNVEEEGNSERRSPVDIVKSNALKKVQKVAEEYRNAIIIGADTVVVLDGEIIGKPKDERDAIRILKRLRDRYHFVFSGVAVMETPEEKVLTSVVRSKVKMRDYSDEEIERYVATGEPMDKAGAYGIQGKGALLVEKIEGDYYNIVGLPLVRLNSLLNRFGYSLL
The following text describes a protein:
Function:
Exocellobiohydrolases (CBH) that catalyzes the hydrolysis of 1,4-beta-D-glucosidic bonds in cellulose to release the disaccharide cellobiose (Ref.3). The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with endoglucanases (EGs), which cut internal beta-1,4-glucosidic bonds in cellulose to reduce the polymerization degree of the substrate and create new chain ends for exocellobiohydrolases (CBHs). The CBHs release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units (Probable).
Miscellaneous:
MISCELLANEOUS: T.reesei produces two different exocellobiohydrolases. They are unique in that they can hydrolyze crystalline cellulose in the absence of endoglucanases.
Subcellular Localization:
Secreted.
Domain:
The enzyme consists of two functional domains, a catalytic core joined to a carbohydrate-binding domain (CBM) by a serine-, threonine-, and proline-rich, highly glycosylated linker sequence.
Sequence:
MIVGILTTLATLATLAASVPLEERQACSSVWGQCGGQNWSGPTCCASGSTCVYSNDYYSQCLPGAASSSSSTRAASTTSRVSPTTSRSSSATPPPGSTTTRVPPVGSGTATYSGNPFVGVTPWANAYYASEVSSLAIPSLTGAMATAAAAVAKVPSFMWLDTLDKTPLMEQTLADIRTANKNGGNYAGQFVVYDLPDRDCAALASNGEYSIADGGVAKYKNYIDTIRQIVVEYSDIRTLLVIEPDSLANLVTNLGTPKCANAQSAYLECINYAVTQLNLPNVAMYLDAGHAGWLGWPANQDPAAQLFANVYKNASSPRALRGLATNVANYNGWNITSPPSYTQGNAVYNEKLYIHAIGPLLANHGWSNAFFITDQGRSGKQPTGQQQWGDWCNVIGTGFGIRPSANTGDSLLDSFVWVKPGGECDGTSDSSAPRFDSHCALPDALQPAPQAGAWFQAYFVQLLTNANPSFL
The following text describes a protein:
Function:
Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. Has activity against C.albicans.
Subcellular Localization:
Secreted.
Sequence:
FLPIIAGVAAKVFPKIFCAISKKC
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MACLLRTAVLRTASSVSVGGPSKMVADAARFSTSTSIFIADDKKDASFARDHRPHSAAGVGPAGATSSSLHAKQEKLGVESGLSGGKTQQDAINSAMGVLDRLARDVASNRTSDSASVAGSQPGSDASGITTAITTPSTPLAAVHDSTIGPIYSPSTLPPCTDPTLEFLTNLLMKDGKKAQAQRFITRTLSIISSVTNSNPLPLIHDAIYKAAPLVKVQSKKQGGKSLQVPVALTQRQSTRKALTWIIEASKKRPDRELERRLAAEFLAVVEGTSSAIVKKEEQHKIATVNRANAAVRI
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MERKLSKKEEEKIVQELNKMQMLEMVDTSVNLTNKCFQACATNFRIRTLDDDEQLCVYKCVEKNTNFLSAINSHFVKLSGDA
The following text describes a protein:
Function:
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Acts in a downstream signaling cascade via cripto and cer1 to mediate cardiogenesis in embryonic mesoderm. Directs the orientation of the left-right axis by driving the left-specific gene cascade in the left lateral plate mesoderm.
Subcellular Localization:
Secreted.
Sequence:
MAVLCFILSLTILSLGHGMPTLLHTKEARFPLQGSTQRLESSSVLHGKRLPHDMKYPVYMVQMYQNLISGTDKSPSVRGEPVLQESDTVLSLIAKGCTQVDSQWILSFDMSSISISSELRLAELRIHLPSLERFQNVTLDIYHTKGNLEKFFLGSLTIDFPGTSGSSWKVFNVTQMLQRYLYQKESFSSDKYTQPKATSQAEQKISCNGLLSERIMLMVFSTDKPSSKLTGSTSLIETAESSKYVITEADTRETGKRRHRRNRYALNSIIRSSFHSQPVGDGKTLCRRVDMIVDFEKIGWSDRIIYPKRFNAYRCEGSCPIPLNENFKPTNHAYIKSLVNHFNPGRVECPSCIPVKMRPLSMLMYEGDEIVLKHHEDMIVEECGCY
The following text describes a protein:
Function:
Meiosis-specific transcription factor that binds to the middle sporulation element (MSE) of targeted genes corresponding to the consensus sequence 5'-ACACAAA-3'. Acts as an activator of CDR1 induction by antifungal drugs. Modulates azole sensitivity by controlling the expression of ergosterol biosynthesis genes. Required for hyphal growth in response to different filament-inducing cues and for the proper expression of genes characterizing the filamentous transcriptional program including noteworthy genes encoding cell wall components, such as HWP1, ECE1, RBT4, and ALS3. Is essential for the completion of cell separation through the direct transcriptional regulation of genes encoding the chitinase CHT3 and the cell wall glucosidase SUN41. Required for biofilm formation and plays a key role in microcolony formation under both flow and static conditions and to epithelial surfaces. Essential for virulence.
Subcellular Localization:
Nucleus.
Sequence:
MHPSAGVNNNQHLNHQPYQQMSHYNAQQMHQQQLHHQLMTPNPYQQHFQQQMHPQLHHEDHLNMHFNPMSYPQQQQQQQQQQQQQQQHLHHFGHQIPAPPAQQGPTPQQPHLHQQIPHPLSHHQTPQPTPQPLAQQQSPQPARQPRQTKKQKQQAQNQDQADAQSQAQQHHMAMMARANQNDMLESSTRKVAPRSSDLFRVGPPFSISKQHQPVYCVGTDMPVTPLLHARIDRGFEMGETGSWIGYKRNYFTLVASFTLQDFDFEKFIGNKFYTYDKVNNKVNGFPPHHPSHPQNQPQNHPGHPHHNQHAGESRVPISYFAIRLVAKCSDEDVAISLIQHTAKRDKGPQFPPPIYPAVPSELPDHETVKVSCNKRNNNKIETMNKIFYFDRGNYYQEYNLDSYKDQSILKSYPSQSISKVARFERIQFTSSIRVKSTNTTARYFTLHVELLGIIEDEDLQIQPILLSSIESPPLIVRGRSPSSYHKDRTSGYRATNTPTPTPPQ
The following text describes a protein:
Function:
Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.
Domain:
Lys-116 may be involved in the precise positioning of the nucleophilic Lys-115.
Sequence:
MLKDEVIKQISTPLTSPAFPRGPYKFHNREYFNIVYRTDMDALRKVVPEPLEIDEPLVRFEIMAMHDTSGLGCYTESGQAIPVSFNGVKGDYLHMMYLDNEPAIAVGRELSAYPKKLGYPKLFVDSDTLVGTLDYGKLRVATATMGYKHKALDANEAKDQICRPNYMLKIIPNYDGSPRICELINAKITDVTVHEAWTGPTRLQLFDHAMAPLNDLPVKEIVSSSHILADIILPRAEVIYDYLK
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus.
Sequence:
MATGRNRGNHKEGGTINIGQPLFQVPHSLRKEHDFFSSQLFRKLQYDLEEVSRSQELSKVSPITRDFIEEAAMTQEMQDLKRAEFVERKRRQQLRRDCEELRDLAEQLRLAAISRDIAENLEEKKRRRQLDIKLEAAEVSQERCLLEVRQREKEVALKEEQRRLRESLAEQMEENRRRRLQEHAQVMNDRELSLLMQKQIQEEDRAQELEAQRKKLQKRQDMLRSIKENQELREWQRAQYNQELSDLVQKQSDMERRKLQLEAERQEIQRKKQEISIRLGQQVLEIENKKRHRDNLLLDLLEAEYTAKSDERYRQQMQQEQMSRQRTRQELDRYRQEVKHRKMAEMQMKRAEMATRQEEAPDTINQNSEKQLDEYRRRRAHGASLLAMIEDNHRKRAEATAENVQYFDMKAKIDAEQEERIKQERLAMLSQVPSSVLRYLPKHVLKSTDREHFCLIDAQARGGGDS
The following text describes a protein:
Function:
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.
Subcellular Localization:
Membrane.
Sequence:
MSPLPRSAPAVRRLMGGQTPPPLLLLLLLLCIPAAQGDCSLPPDVPNAQPDLRGLASFPEQTTITYKCNKGFVKVPGMADSVLCLNDKWSEVAEFCNRSCDVPTRLHFASLKKSYSKQNYFPEGFTVEYECRKGYKRDLTLSEKLTCLQNFTWSKPDEFCKKKQCPTPGELKNGHVNITTDLLFGASIFFSCNAGYRLVGATSSYCFAIANDVEWSDPLPECQEISPTVKAIPAVEKPITVNFPATKYPAIPRATTSFHSSTSKNRGNPSSGMRIMSSGTMLLIAGGVAVIIIIVALILAKGFWHYGKSGSYHTHENNKAVNVAFYNLPATGDAADVRPGN
The following text describes a protein:
Function:
Contributes to the establishment of a polar lipid barrier to block small molecule passage into the pharyngeal cuticle. Probably exports polar lipids into the developing pharyngeal cuticle to protect against xenobiotic insult. Likely functions in the same pathway as sphingomyelin synthase sms-5.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MAPKDDPDNRGFDDQRRPSQRSTVLAIPALAVNDPKSDPKIASDLPANYVDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFRNKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPEATEEFEEEEIDLDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSAFAANEAAIMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIGILGTSLILLLAFVMIGLAYKISLMNVEQIQNDDAGRIAIEIIENVKTIQLLTRCELFFDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGIIAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQDLAV
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDVPMKEQEENARQPEGSEPVPAKEIAKQKTMERLKKSAKMAEKLQRKRKTQETDETTDLLEEEQSVADHDLVPLPQPNVETLLHGQEDKKRTRSLQALPDWIANPTVVAPSTTVQFAELGLSKRLVELLAQNNITQGFAVQAGVIPLLLQSSNKSIQRAHAPGDLCVSAATGSGKTLAYVLPIIECLRTCIVTRLRCAVVVPTKELVVQVAKSFEQYCSGTKLRVCALTGQRSLAFEQSLFLSPNGKDYIADIMVTTPGRFVDHIRSTPNFTLQHLRYLVVDEADRLLDQSFQGWVNAVMEELERPKVLQGIDMHGLSGIERLPGADSNSGCNIASTYLPNMPTLLPQKTAPCLQKLVFSATLTRNPAKISALRLVRPRLLVVQDPSVSMEPDGDEEDTVLFSLPAALQEHHVGVTAEKPLLLYHLLRTQQLQNTLCFTKSNESAARLYRLLELLDKGSSEPLRVGLFAGILTRADRRRILTQFAESNLQLLVCSDLMARGVDLPSTENVINYDPPSGTRQYVHRIGRCARAGREGHAWTLVQDHEGFHFSSIVRRLTRTLPVQRMRLTLPNVDPVLVKKYDDALSTLKSEVYEAKHAHN
The following text describes a protein:
Function:
May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAGGRRGPNRTSYCRTPLCEPGSAGGAVHGGIPSVSGVRSRARSSSSTGLSSPPLATQTVVPLRHCKIPDLPADRHLLFELQLFFCHLIALFVHYINIYKTVWWYPPSHPPSHTSLNFHLIDFNVLTLTTIVLARRLIGAIVREASQGGKSSVPHSLLLVATRFAVLTGTGWSLCRSIILLFRTHSFFNLLFLCYPFGMYIPFLQLGWDFRRPGLSHMPNTRDLASMDRGSKDYLHVLQHILRHHMPSAEPLPTHACCLSPDLIRSEVHYLKLDFNWRVREVLLSSMLSAYYVAFVPVWFVKSTQYYDKRWSCELFLQVSLSTSVILTQHLLPARYCDLLHKAAAHLGCWQKVDPALCSNMLQHSWMEECMWPQGVLVKHNKNVYKAVGHYNVAIPSDVSHFRFHFFFSNPLRVLNILTTLEGVLIFYQLYSLLSSEKWHHTISLALILFSNYYAFFKLLRDRIVLGKAYFYTAVPDCERKLN
The following text describes a protein:
Function:
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (By similarity). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway.
Subcellular Localization:
Cell membrane. Note=Also found in extracellular vesicles different from exosomes.
Domain:
The PPxY motifs mediate interaction with WW domain-containing ubiquitin-protein ligases.
Sequence:
MGRVQLFEIRLSQGRVVYGPGEPLAGTVHLRLGAPLPFRAIRVTCMGSCGVSTKANDGAWVVEESYFNSSLSLADKGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAKRWIYDVRTIAEVEGTGVKAWRRAQWQEQILVPALPQSALPGCSLIHIDYYLQVSMKAPEATVTLPLFVGNIAVNQTPLSPCPGRESSPGTLSLVVPSAPPQEEAEAVASGPHFSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHSLHPPLCISIGATVPYFAEGSAGPVPTTSALILPPEYSSWGYPYEAPPSYEQSCGAAGTDLGLIPGS
The following text describes a protein:
Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
Subcellular Localization:
Membrane; Single-pass membrane protein. Membrane; Single-pass type II membrane protein.
Sequence:
MESGGRLCMKAVLLALALLTLISLLAIGYLCPQSVCSAGKLGLVGRGSRDSMGGPLSFLSQPLRSDRRNKLSFDDMLGDDFEFDMKGSDVMVFLHIQKTGGTVFGRHLVHDLDLEKPCECQRGRKRCRCNRPNSSGKWWLFSRYSTGWKCGLHADWTELTACVDSAMDRTEKTTAKRSARVCPWPGLLACSFARATLYSGSLVPLGQSKGSRASAHFSRLVPNFLFDVEVLLRDAAARARGPLPERVPARAAWRHLEGLSALVRGTGPHQRGIATLLQRHRLEGRHFPGVHRLPVEPGCESADAHAGRPVPGGLLQPDGSGGVRAGPAHADKRQGQPAPHGLLRPHGAPAALAAPLRAHLQAALPQALRTAQRDAQHGCLRAGMSI
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
KHSTLNRAQAVFGFFTTVALFVAGFAALSVLLFPTDKINTEVSLRDVKVIKGRPHYYSTKKEEYAQMRFDLDADLSPLFNWNTKQVFVYVYATYSSSNKPSENSLTPQSQAIIWDTIIEAPESPYSFANLREQFFPTKSGKSASSRKRSSTNKRNDSNKQDAVPGTLRLRNQKSKYQISDITGKMAERTNVTLSVGWNVQPWVGALWWAPGTGAVPRTGGSTGVSRAFDLPALKGTKPKTEGAEASV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MYDINKSICAEIKSAELDVLNSGELRRISMGKYENEKYEYEKTHKSGVVTKMYYDPKYGTIDHNQICSVCFERHENCTGHIGHIEFVLPLFNPLFYKELQELLNLICYHCYNFCCSEDVIFLLKHIFQLKSLNQIESTNKIKYKKNCDYEYIIDQVEKLYKKICKDSNISLDDIVEAIYDDYENVHEDKDGNFDESVDLLDSLEKIKDEPDEKNKNNNNKNNNNNNNNNNNNYNNDVDIDVDNNNNNVDINVDNNNNYFNSDLVDLAPNEEIYEEETDAGRSDDNNKENKPDYNKLKERIKKYKFDANKLAFQSNYNYEEYLILSKTIKLHMKKSSKCCFCKFQRNISAKVSQRRDTINFIGVHTNNPFFKKYMPKKKQKKNEKDDQEDVDDLENMNNIDDINYNDDVDNMQHMNDDESQLNSIQSRNENNKLMIKRESKKIEYNNNVNDESIKIEEDNNEDDDKQMDRESSYPHNNNNNNNDNNENYNKLSGGYENSFNEISTDNIRNDKNKNSTFADMVNHYNRTQAPKEKCTIRLFSFQVIDILKKIFENNNKDIINLLYPFTKRDGYKKFFLYDMGVSGNRFRSQSKGIHVRTKITNTLCRFNNFIKLCINAKKKVDFDYLLEHNKKDLKLYKDMFSVFSLKMKYKFNNNIMDDDTDITKMDFLKYYTLVYNNKSAYINILFSTLQLGVNTFYDSTLTEKVNNKHLKNISIRQILDKKEGILRKNIMGKRVNNCARTVISPDTFIETNQIGMPIEFAKVLTIDEYITQNNFTYIKKLIENGPNIYPGALSYRDSNGRVFKLSHKYEDRLKVIEKIEKLNFQTENSYILHRHARDGDVVIMNRQPTLHKFSIMAHYLKIFEKEKVFRLNYVNCSSYNADFDGDEMNLHLLQTPLARAEATHLMNCDFLFTSFKDGSPLRGLAQDFILGGLHLTSLETFLNYDEYCNLLQCSLNSLISQKNSFFIKKKNNNNNNNKKNTNRTNSIMKNTRNSQYNIIQNDLNNNDSKEDYLKKMSILKNQQSLDDNAKISHPVSNDEARNNSIYEPTNNLLKPQDIDILKEINHGEQFNGNVLKITNYNYLDPYAIILNRTSFTIITEEPAILYPKKLWTGKQLITSILKTVIDKVAIETYNKYNDNEFMNTYKGINYVAKAKTSPDLWSFDPLKENEVIIKNSELLQGVLDKLHFGASSNSLVHLCHELFGPKTSAVMLDCFGRLFINFLQLRGTSLSLYDFILNKNAKKEKSLIKKRISFTGFYLQNLFAYSIANSVNADITEMNSYTKKKMNTGNQRKKLILNKMYDLYEKQNELINNNFNEKENYLNKMEKRNIKKDSHVMKDEHILSISENSYLLALLNKELQNVIYHILNEVQFCDDDASLLNKEKNEKENEKENKIANTCINYKHNNSHVDDEQNCNSSLYSCVQYVLNKDLFNLYEKYLNGKNEEANKHILYNNCQIDERNNHFLNSVTNKLYKALKEPTFFNSTSFTIKKITKVIEKVLTFLKAARCNKRLKIYIIFELFQNKNIMKYFPSLVNYINSFHFDVSNEEIIKNVINNIYFKEEDESPISSINNNNNNKVEDDCNQDIKIKGDQETNEFIDDEKIKTKRKCSQEKTIQEIKKYKLKKFLHFYAELHKKCNYEEGRGYDIDEQNDYNIDEKDFMNDYNDNNNNNNDNLFRRSFVKNEMMSVNHTSDDVYDEKIIRNCLMSSLPSFTLNDEITNLSYNGKYQYYEDYLCSKKKDEEDLNFKYYNMDDVFYKMEYLIHNYFYLKRSDFDNLIDSLFQPYLCRVSSGTNNLINMNNLMNKFLNNGFSNMIFTGAKGSKVNYSMICGMLDQQYLEGKRVPRMRSGKTLPSFHRYDYGARSCGLITDCFLEGLRPQEYFFHCMSGREGLIDTAVKTAKSGYIQRCLIKCMESVILHYDGTVRNEDNSIIQFLYGEDGIDPSKTAYLDLSKDLLHNYHLSFSKYLNNNMHSKILNNQELFLKHEKDNDTKDNEEPLISKYNPYTYIGSVSDKFNNKLNNTLLWNDLNFPEYENVPMNFDTLSSSLLKSKYYNSLCNPGESIGILVAQSFGEPATQMTLNTFHLAGTENVTMGIPRLKEIFLTSKLTSKPMIYVPIKLQVDNLKNDANKMKNYITSIADKILSSYKSIFLTDVIYGIGVDRKIILKENQNEQKHTINLSDIINMNDEELSGDTQLAKINNVLKNCNINFDMKKEWNYEIIIQFENLYHFCNINKHLTISFILYKVVNALLNSVLNKVHETFVFHNLINMNSLNHEYYDELYDFISKKMSEEFNFNMDKYEYKDDEHQINAKLKFMEKENERYDSKRGTNNNISGEYQNASHTIASHMEDDSPMKSYNDISNKENMSPYDDGKGKDGDRDQDDMSDIELKDNSEKNSNSDQASKNADSDTDEEEEDDELKSEKEKEEDEKEYDEEGESDTNSKIDSDHKSDSDNKSDSDNKSDSDHKSDSDHKSDSDHKSDSDHKSDSDNKNDSDNKNDSDIDSDSESEMVSSNKKEIININNKDNYYTNRNSSNESKLSECSNTKGSTVNYFSSETSATHHILVDEEESGIFPNLKNKKLNNMNDNKNMSSTTVSSSLSSSSLSTPLNKKNIEDDEHINNIHFIEKNKYNEEMDNKEEFITKSFTRLSYDYKNNINLISSDDDQENIEENEEGQKMKKSEQRYVKNIIDKIKSSLLCFIKNIHFSPVTWILKLNIGWDINFFPYPIDFLNHIKSEINKEVLFKVKDLNNPKILKGKDITHSGAEYELQIEGKNIYKLYNIKDKYIDKTKLYCNDIYAIVKTYGIEAGRLCITKELKKVFDAYGIQIDFRHLSFISDFMTHTGDLKAFNRHGLGYFRNVFHKMSFECATNFLIQGCIHNSIDYLSTASSSLFFGKHIKVGTNLADIVTCIDKQNL