lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication.
Subcellular Localization:
Mitochondrion. Cytoplasm, cytosol.
Sequence:
MPSLWDRFSSSSSSSSSSRTPAADRPPRSAWGSAAREEGLDRCASLESSDCESLDSSNSGFGPEEDSSYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLSQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSSANSSLVPGYSQSLTLSTGFRVIKKKLYSSEQLLIEEC
The following text describes a protein:
Function:
Component of the cuticle of the larva.
Sequence:
MKFLIVFVALFAMAVARPNLAEIVRQVSDVEPEKWSSDVETSDGTSIKQEGVLKNAGTDNEAAVVHGSFTWVDEKTGEKFTITYVADENGYQPQGAHLPVAPVA
The following text describes a protein:
Function:
Serine/threonine-protein phosphatase that plays an important role in controlling colony morphology, filament extension and agar invasion. Down-regulates expression of NRG1 and affects the expression of multiple filament-specific transcripts in response to serum and 37 degrees Celsius. Plays a crucial role in virulence in a mouse model of systemic candidiasis.
Sequence:
MTVPFKIPISDLDYCLEQLLDHKPPKILPPETIQQLCHTLKTELLQTPNIISLQSPISVVGDIHGQYHDLLEIFQIGGSPPQTNYLFLGDYVDRGYYSVETISLLLVLKLRYPERVFLIRGNHESRTITTNYGFYTEVLNKYQGSADVWTFITDLFDYLPLGATIDGKIFACHGGLSPSCQQLDQIRAVDRFREIPHDGIMADLVWSDPDVAISDFKLSPRGAGYLFGNDVIDKFCQDNNLVQMIRAHQLCNEGYTSYWKGKCLTVWSAPNYCYRCGNKASVLEILHSNYDSKDPTNGSDGEISSINGEFIGVNTSFESFGDDDDDYNDYRNRFNNSSRLHKQQGVLPGQFFNVFEASKENDEDTLQGKSVNGINFDDELSTSDDTSGSGGNNNKGDFFAAFFQERPKRQQVEYFL
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MSTDVSERGAEAGSSSGLLSSPCVGDGSDSAQMKKRNTETAGMKARKKLRSEESGLSTLVSIASFGGQASPDRSKVSKQQNGASGHRPVTSCTHCRQHKIKCNASENFPSSCSRCERMGLQCEIDPQFRPKKGSQLQNLKNEIEELKTKLEFLLRSEGILSSAMRNSDLGRQILQAIKLQDSPQQQTGISVQTYLASEPELLKSESSVKSSVNTPSGSYSASAVDVSRAKTNSVPPLLNDSAPANSNRESLPPVLQMALKYHNSSHNTPIDTPSSHTTPMLSPEVKKPVVATTNAMPLLPSPYANIDEFVLGDVHIPIDKAKELHHIFVKKYLPYFPIMTTDSVTELYSQSQLLFWTIMLTACLSDPEPTLYNSLASLIKQLAIETCWIRTPRSTHISQALLILCNWPLPNQKVLDDCSYRFVGLAKSLSFQLGLHRGEFMSEFTRTQTLMPDAEKWRTRTWLGIFFAEQCWSSILGLPSTSQTDYFIEQARRGKFDLPVRFHRLLCLAHFQASLSNIMGSSVESPDGLMDAKERGSSLAALERELARLHSELKFDSDPVVEMYYLYAKLMIYCFAFLPETPKADQTQYVTEAYLAATRIITLLTKTLEDTQLIELPIYVRQSVTYAALILFKLHLTPYLPEKYVDSARQSIVTVHRLYRNQLTAWATGVENDISRTASVLEKLNFVLITYPEIFVEEDGIISRMRSHLTGTLFYDLIYCVHEARRRQVDSEYNEMLEKNRKEQPVHTAATGSQDTEKRAPKRRLFPLPFYNQISKEDFETITQTTPGGTTVTTLVPTKNAILQAKKLQRSQGGQKGEPIRSINGIPLAMLDATGSVNGALVGDNLNSSVPQAAVAASAPPEPAAVAATVPPEPAPAPGGQSYPLFQPLYVQPAANVPMQRSASASVAEALPFRRPGMPKITSESIASGNPNSLFGNDGSPFPAIAQKSAKPAPPAKPDGQPAKQPAPYPNLNVFLGANASARMASYSSLMDAADPLAPDPDRAPLAAPGPLAHISELDSFFLQQSAGWIEGSSSNDDFLGWYDINMAPEF
The following text describes a protein:
Function:
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Subcellular Localization:
Cytoplasm.
Sequence:
MRKLKEIVEYVREYVIETRGYLDGNITGIATDSRKVKEGNIFFALPGTRDDGRRYIGDAISKGARAVFFEGEVDNFERDVALIRVKEIFDVLSKVSLYFYNFPSKHLNIVGVTGTNGKTTTTSLLYHYWKGKGLKSGLIGTIDYRIDEESYPSNFTTPQPQELQEILSKMVNKGVKFLAMEVSSHALSLKRIDGVSLKAVVFTNLTQDHLDFHKTMEDYFQAKLKIFDHLEDEGFAVINRDNEWTKRINLADKRVLWASLEEGDIYLKKYENTNSGMILEIATPLGDTVIDTKLRGKFNIYNILFAVGVLIGLGEPLEDISKILSTFKGVKGRLEFIREGQNFNVIVDYAHTPDGLYNVLQTIKEFTKGRVIVVFGCGGDRDPTKRGKMGEISAKLADVVIVTSDNPRTEDPMKIIREIEKGIKRVGRLDYFVIENREEAIKKAIEIAKEDDSVLIAGKGHEDYQIIGTIKIPFSDQEIARKYILERLNNEA
The following text describes a protein:
Function:
Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex. Potential tumor suppressor in gliomas.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytosol. Note=In astrocytes, colocalizes with VCL to the end of actin stress fibers, which normally terminate at focal adhesions. In hepatocytes, it is found in the cytosol.
Sequence:
MSDDIRKRFEFPNSLIQSQAVGHLIAAVLKENGFSEKIHQSTNQTPALNLLWEKCCSDNVVVRTACCEGLVALVAQDHAEFSYVLNGILNLIPSTRNTHGLIKAIMHLLQMQALKEGQGGEKNIQSIYTIRNHPHPLITVLEHRPDCWPVFLQQLTAFFQQCPERLEVSCIQIMAPFLWYLYCEPSQLQEYAKLRLALLKVLLQPQVLCDKDQPSILEQQILQLCCDIVPCLQVKDLIQTTEAMMFIEEVCLSLLRHPVFWKIQLTQMSLQLLCVSEVSLKITGECSSSIHLLEHSVELLKEDFPVELVIIGIALLLLQTPASQQKPILNLALKLLSVTEDQKIPKSSLLLVMPILQILSSTALEDCISVDEEGPSRQQLALNLLEMIQQECYRDDHQKLSYKLVCPVTSMYGTIFTAWRILEVMTDSSAASDWLASVESLLPITAVIPAPAFLLLAHLLVEDKGQNLHQILKVTTELAQADSSQVPNLIPVLMFKLGRPLEPILYNDILYTLPKLGVHKVCIGQILRIIQLLGTTPRLRAVTLRLLTSLWEKQDRVYPELQRFMAVSDVPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQATPAALVLQGLHALCQAEVVCIRSTWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTTEYENFKVQVLSFLWTHTQNKDPIVANAAYRSLANFSAGEHTILHLPEKIRPEIPIPEELDDDEDVEDVDLSVPGSCYLKLLSLTPPLVLPALEEFFTSLVKQEMVNMPRGIYHSALKGGARSDQGKTVAGIPNFILKMYETNKQPGLKPGLAGGMLFCYDVSMYQSKDGKPLNRLMASRGRSFKQTSLALVHEVHIQLSEWHRAIFLPQAWLAYMNRAYHAILQGRLGELELQLKHGKEEPEEVQYKKSTAWLWVRDMLTDEITKAAAKESPVVKGNALLALSSLAVVVSRHEASLSSDSDGLLEVQPNFLSMKEWVSMVLDTLLVIVDSHYQPRGQLLSWFYYKSYSGENTASAIARSAAATALSLLVPVFIISCKEKVEEILNMLTARLPGKPSADESQAVQIHMGLALGMFLSRLCEEKLSDISGQEMNLLLMKSLDALENCCFDTSLEYNTGCILGVGLVLSLMSHSSQMQSRVHVAALLRKLSAHVDDSGSQSRTFQEVLAYTLSCVCTSAFSAGIIEATEAEDVMNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGSKLLPAWIRIVLTEGTPTMLCLAALHGMVALVGSEGDVMQLKSEAIQTSHFQGRLNEVIRTLTQVISVSGVIGLQSNAVWLLGHLHLSTLSSSQSRASVPTDYSYLPESSFIGAAIGFFITGGKKGPESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQAQSSQNAAALLGLWVTPPLIHSLSLNTKRYLLISAPLWIKHISDEQILGFVENLMVAVFKAASPLGSPELCPSALHGLSQAMKLPSPAHHLWSLLSEATGKIFDLLPNKIRRKDLELYISIAKCLLEMTDDDANRIAQVTKSNIEKAAFVKLYLVSQGRFPLVNLTDMLSVAVQHREKEVLAWMILHSLYQARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSFHNTALDKALDFFLLIFATAVVAWADHTAPLLLGLSASWLPWHQENGPAGPVPSFLGRSPMHRVTLQEVLTLLPNSMALLLQKEPWKEQTQKFIDWLFSIMESPKEALSAQSRDLLKATLLSLRVLPEFKKKAVWTRAYGW
The following text describes a protein:
Function:
Catalyzes the alpha-1,2 addition of a mannose residue from polyprenol-phosphate-mannose (PPM) to a monoacyl phosphatidylinositol tetramannoside (AcPIM4) to generate a monoacyl phosphatidylinositol pentamannoside (AcPIM5).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCRTLIDGPVRSAIAKVRQIDTTSSTPAAARRVTSPPARETRAAVLLLVLSVGARLAWTYLAPNGANFVDLHVYVSGAASLDHPGTLYGYVYADQTPDFPLPFTYPPFAAVVFYPLHLVPFGLIALLWQVVTMAALYGAVRISQRLMGGTAETGHFAAMLWTAIAIWIEPLRSTFDYGQINVLLMLAALWAVYTPRWWLSGLLVGVASGVKLTPAITAVYLVGVRRLHAAAFSVVVFLATVGVSLLVVGDEARYYFTDLLGDAGRVGPIATSFNQSWRGAISRILGHDAGFGPLVLAAIASTAVLAILAWRALDRSDRLGKLLVVELFGLLLSPISWTHHWVWLVPLMIWLIDGPARERPGARILGWGWLVLTIVGVPWLLSFAQPSIWQIGRPWYLAWAGLVYVVATLATLGWIAASERYVRIRPRRMAN
The following text describes a protein:
Function:
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MDFYYISQLTERSDTKLYSVNWPGKWIAENPADAIGKGNDEIEKMSMITSNNEQYECVLPKKENQKATKESDRSDTEPPEILLSTLFSKKRCTYRMEGYWSYELCHGRHVNQFHENSKGSFDHHYVLGAYKKSKLPVTPNDEKIPTKTIASKDFPYYKLVMTDGTPCDLANDKPRQTSVYYICDENAKDEIIILKEVITCEYEIVVATHLMCKNKNYRPKEEVINQIHCHSVSDSPSVPKAELELKDSILKLQNRNVMYEVSSKQGIPSVSGKKDPVASAVSGEDPMKSFLKGTFCLNGDQVSGKTVILLGTWDVNVRYYYHMCKEHKRWFINSKKDSAHKSTMELFFGKGDVCDATAMPRKVVVRLRCRNDLTTPNAIAMYLLEPSTCSYILVIESVGICKLLGSRDEFGIIKSP
The following text describes a protein:
Function:
May be an activator protein for the gylABX operon.
Sequence:
MPAHTTHDAARDEAVAPLLRGIAVLGRLTGADGGTLSLSALERTTGLARSTVDRLTATLARMGYVRLDGRDVVLAPRLMELGNAYLAALRLPALLSARADGLADELDESVSLAVGDRDGIRFIHQATRRRAMSLSFRIGDLLPAERTAPGPLFAAEWTASDWHRWRERRAADPGDHSFPAVPPREPGAPGEDFARRAAKAAADGWALDDQLIEPGLVAVSVPVRDPGTGRVACVASVVSHTSRHTAPDLRAALLPRLRAAVAAMEDDLRAAPAPEPGPPPAGLALWTGASKQELGREFVESLARGLTVLTAFGEGRSALTLTQVAQATGLARATARRALLTHARAGLVAPAAGHTFTLTPRVLSLGFPPLSRTSLPEIAQPHLTALAERVHESASLAVLADSGEEIQYTARASAARVLSARVTVGTRLPARATALGRVLLALPEVRARGYALVDEELEAGLRAIAVPVRDRTGRVVAALNVALHAARRTADDCVAQILPELRHTADLVETELRVAGRFCRVAVV
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MSASEGHWEPLAEIYLSHPLVKDKKKSIYCLCSRVFIKNYYDVYVSTLERGDSVPLITSMDPITQAEQGNASSAIKSVEAKCAEGAVVAAAQQPAGGGGDEILDVLDRAEVDDVFIEEPLVKQLSFGRDGARKLTSKWGDRDPGTTSDASCYFSASASHSDTNYCSTDEHEHVLYASGGGSQNIVAGLTTGNSSVRNIVTCGLHSSDSGADLSERIHERKLSLKDELLERSKTNAEDGEHGRGSGGPIPSLASMERNNSLPEAFGREDLHEAWETYWNKHGEAIIWASWIEKYSDYINPEYLEPGDQGQATGTNTPHDKSEATPGTATEVDKDFSFDNDAITAASAMEIVVSACSPHPYTKSTYQMAHWSLPFGEGAGGSGSGIGDDALWSTHRSGSCENEALLSPRCDSVTSSIPLTVGTTDSMTNVTRMTISSYDFCSSKVSSESSNLSESLSSEISNESSNSSDMLETEYLVGANRATGATLPPDEEAAMDGEQYWQILWQQHFQELYAKQYHHFMAEHAHDEANTGCGERNSSSKYYKRKRNSNNGACRGDAHSYQLPQPELQLPEMVAEMRLSQAETASEPKDGNDETSNKEKSDGKTVESAEDLSAVLQSYGLPTAFGKQTQQPAGDGGEDRPPNEKPINLKRSHESDNEETPKERLKAAFELMGYCFSDSANETESIINISGEVVYRKKHIRLHNRVLKMKHHKPKHSYFDDEGNELQTASGGDKTDAATSADVLLLHSSSDDDEANPGAVGRASVRSSTILEMNQLPPAVVGKEVDSLESGDGTENVLETPGIASSESGCNVPTSTTKKEKKKKRKTKFVASLPADIANDRSLLKYWYKRFSLFSLFDAGIKLDRESWFSVTPEKVAAHTAERCRSDLIIDAFCGCGGNTIQFAFSCQKVIAIDIDPRKIEMAKHNAAVYGVADRIEFIVGDFMQLVDRLQADVVFLSPPWGGPGYLKDEVYNLEQSLLPVPATQLMEAAQRVSKNIALYLPRNSNTQQLTMLAGPNGAVEIEQNFLDRKLIALTAYYGDLINQ
The following text describes a protein:
Function:
Involved in pre-mRNA splicing as a component of the spliceosome.
Sequence:
MCLYKDKERICPRISAAAVTMSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRLEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALRQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, catalyzes the addition of the seventh and ninth alpha-1,2-linked mannose residues to Man(6)GlcNAc(2)-PP-dolichol and Man(8)GlcNAc(2)-PP-dolichol respectively.
Miscellaneous:
MISCELLANEOUS: In the absence of ALG9 activity, the N-glycans transferred to proteins are aberrant, indicating that the oligosaccharyltransferase (OST) complex is substrate-tolerant.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDLTTTRQRRPLISDSSSSSSTKSYSKTDKPGRSNGGDAEDGGLRWFLPFIALCYLRYMSATSNIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALRSYLYILFHELAGRPASWWFGDDKVRVFYAVRLFLGLVSAVSDTVLVVALSRKYGKRIATYAVAMLCLTSGCFFASTSFLPSSFSMYAISLSSGLLLFEKYAMAVAVSVVGVILGWPFSILAFLPVVIYSLVKRFKQAFIAGAVTTIFLLGVSLLVDYYYYKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFNFCFILAMLFVAIYPVIRRKYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLICVSASAVIENIPELFREKYSSRESLLVTITKYMRPVILGCILCASHSRTFALINGYSAPLEVYKLLEHHDDAGPGSVLCVGSEWHRYPSSFFVPHYISEVRWIDDGFRGLLPFPFNNTLGGTSASPPYFNNKNQASEEQYLKNIETCTFLIELQLSRPYQYRGSDLSTWEAIAVLPYLDRELSPAKYRSFFIPHMWQEKNVFGKYVALRRVPK
The following text describes a protein:
Function:
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Presynaptic cell membrane.
Sequence:
MWAWTLWMLPLLCKFSLAVLLAKPENISCIFYYERNFTCTWSPEKEASDTWYTVKRTYCFGRKSDHCTTGNSTSTARTSCSFYPPPITIPDNYTIQVEAQNADGIIKSDITQWRLDTIVKTEPPEIYSVKPVLGIKRMVQIKWKRPVLAPKSTTLKYRLRFRTVNSAGWMEVNFKEGSNGDTTYNLTGLQAFTEYVVALQCVAEESVFWSGWSQEKMGTTEEEAPHGLDLWRVLRPAMVDGRRPVQLLWKKARGAPVLEKTLGYNIQYFPENNTNLTKTVNTTNQQLDLYLGGETYWVSVISYNSLGESSLATLRIPAIDEKPFQCIEAMHSCLTQDQLVVEWQSSASEVDTWMVEWFPVLDSEPSIFSWESVSGARNWTIQQDELKPFWCYNISVYPMLQDQVGEPYSIQAYVKEGIPSVGPVSKVENIGVKTVTITWKEIPTSRRNGFISNYTIFYQAEDGKEFSKTVNSSILQYGLESLTRMTSYTVQVMASTSAGGINGTRINFKTLSISVFEIFLITSLVGGSLLILIIPTVAYGLKKPNKLKHLCWPDVPNPAESSIAMWRGDNFEDKLNVKEFDDSVNMEEERILKPCSVPSDLIDKLVVDFENFLEEFSTEEPGKGQENILGGEKNEYVTSPYRPYCPTGKHFKELPLATEIPSRKSQYLSSGVPEGTSSEDKEQLLSSASSLGLDHLCEEGAPNPYLKNSVTTREFLVPEKLPDQTKREV
The following text describes a protein:
Function:
Involved in countering a host defense mechanism which, following viral infection, activates the host anticodon nuclease and shuts off viral translation. Repairs 5'-PO4 and 3'-OH groups in the cleaved host tRNA. The nick ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nicked duplex nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated nicked intermediate. In step 3, the RNA ligase directs the attack of the nick 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP (By similarity).
Domain:
The N-terminus contains the nucleotidyltransferase domain. The C-terminus probably confers tRNA specificity.
Sequence:
MQELFNNLMELCKDSQRKFFYSDDVSASGRTYRIFSYNYASYSDWLLPDALECRGIMFEMDGEKPVRIASRPMEKFFNLNENPFTMNIDLNDVDYILTKEDGSLVSTYLDGDEILFKSKGSIKSEQALMANGILMNINHHRLRDRLKELAEDGFTANFEFVAPTNRIVLAYQEMKIILLNVRENETGEYISYDDIYKDATLRPYLVERYEIDSPKWIEEAKNAENIEGYVAVMKDGSHFKIKSDWYVSLHSTKSSLDNPEKLFKTIIDGASDDLKAMYADDEYSYRKIEAFETTYLKYLDRALFLVLDCHNKHCGKDRKTYAMEAQGVAKGAGMDHLFGIIMSLYQGYDSQEKVMCEIEQNFLKNYKKFIPEGY
The following text describes a protein:
Function:
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Subcellular Localization:
Nucleus.
Sequence:
MATKAAAADPAAAAAPPAAAAPAAPAPAVSLDETKAKNVLRQVEFYFSDSNLPRDGFLRKTVEESEDGLVSLALICSFAKMRSHLGLDAAVKEDGVPETTVLAVAKVLRCSAALRVSEDGKRVGRANELLKPDEIIVQIDSRSIAVSPLPHNVKLEDVQSFFTQYGKVNSVRLPKHVSDKRQFCGTALVEFSEEDEANNIMNNKLSFAGADLEIKTKKEFDAEMEAKKEAYEKSHPNAHPNKNGHDEGYPKGLILSFKLKRILADGDTEQNGGDKVDNSDNAKKEGASDSAEESGKASEEKAPENTDAKEEKPDDAEELKGSDAQSVKKDDKSLSENDKEPVSREDFKEYFAKFGTVRYVDFSKGDDSGYLRFEESTAAEKARAFAALADEGGLVMKGHLVTLEPVSGQAEKDYWSGIKGGQGRFNNNNRSNRGGRDWKNNRGAGGRHHGGGKRGGRHSDNHERANKVQKLDSSP
The following text describes a protein:
Function:
Plays a role in primary ciliogenesis by modulating actin polymerization.
Subcellular Localization:
Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.
Sequence:
MAAAIGVRGRFELLSCSGPGWLISLSALLSVVARGALATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDVRPEDFIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNSSSWVLYNLASFYWRIKNEPYQVVECTMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSAFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGDDSSTSSMMSVNFDVPTNQSDVSESVRSSPVAHSVLWVWGRDSDAYRDKQHILWPKRADCTDSYPRVPLGGELPTYFLPPENKGLRIHELTSDDYSSEEEAQTPDCSITDFRKSHTLSYLVKELEVRMDLKAKIPDDHARKILLSRIKNYTIPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQDIPLVNLANLLIHYGLHLDATKLLLQALAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALKLTTRCPECESSLKLIRCMQFYPFLYNITSSVCSGHCHEKTLDNSHDKQKYFAKPQSLDAAEEEPSRHGADEDPVLSVENAGRDSDALRLESTVVEESNGSDEVEKSEETKMSEEILALVDEFQQAWPLEGLGGTLEMKGRRLDLQGIRVLKKGPQDGVAKSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKPPGKKVEASQAENGQRYQANLEITGPKVASPGPQEKKRDYQSMGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVVVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP
The following text describes a protein:
Function:
Probable histone acetyltransferase (Probable). Required to initiate and then maintain lateralized gene expression in the ASE sensory neurons. Involved in determining cell fate in the ASE neurons.
Sequence:
MGKKRKPSPERSSDEDEVSTPSPKDRTARPTAAARRENVALSQAVALSLEDASNFCSLAFSLERIKREPVDTDYDDPNQPGPSSVPVSARTDHVLPIRFKIKAEPQEYDSDEYGKDHGAVQIANKEVPAISPIEEVSQKRRGRPRKTDAAQHLFFPHVSIKQEPDDGFINFHESRCVGIAQDPEMQHLHDVNESHSSEIAIFRETKKITERKKKKTEAEKLWDNMSLTEKEVFQSHTRRRRTTRLPIIQNFEETEEGCIVEVPIPLIDLDNDAVESVTGPQHENVTVSENVLSTESTDQEVTETKRLHDSSRDFNPPRIQDTPSTVIRPEGDQKDPMSSTSSKRRNTNNSRCASLLSNPHSTPVTRLMRGILDSENSDNDEMLSNDQSEIAKRPRTPRPRYSPEAQRRTNSRLSALTIDTNRSNDLNVDGSAPSSSSAASCGLSTPDPDRTSQQRRKGNQSAARSRKIKTPSPPLSQEDEPMELDSDDDPVNELDNLPIVIDDPSYVLTKEHKEIFEQVKKSVSDRNEFSPAQISEIYRSSKGEQARLPERIHFGAFIMKTWYGSPFPAEFINVKKLFICEFCFFYARSDEIMQNHAKKCMLRAPPGLEIYRKGDISVFEVDGRLQKEYCQTLCLVSRMFLESKTVFYDTEPFFFYIVTINDDIGCHFAGYFSKEKYEPDVNNLSCIMTLPCYQEMGLGRFLIDISYALSRKEKWFGGPEQPLSELGRKAYGGYWRTTIASCLGRLKDELEFGSGISIKMIADDTGVNCHDILEVVCSLGWAKPVDPDEKNHYKLEWDVDWDMVSIILRESEASKETKVQYDPECLDWVPRKMRPSMDGYHELSKEEIEQDEQRRKSIQKTPVHVSMEKATPTSTTSLPVGSVKKELRSRGHNRSVGRNLKHEVNRKVKVPEWAAARDLTDEEITVEENKKQQKQNRKIFTRCADSVLDKSNIREETPEDDEPGPSTKPSGKRQRGNKCNNTESEPNPSGRKTSATSSGRGKYRNRRTDGTEEEEEDDDPTDSEPLTTDDEKPFETSVNKEKNEKSRRGKKVSKKRRSVAGKKFPPNFGVRDRDEPKKAENSEDGEGLESKPGPSTEMILVEKVEEEEAKVTVSDINMQASESKIEGIEQTSEVDIPKSDEDHQSTEAYDRVEDEVPITDYNIPTPDSYHSSPPHSPTPSPQPQLMQAQQNIYQDNDCHFAENDSKPPHLVSEVDDPAAPQPTVTLQSGPSDAPPLSHNSVDGYSTGDDDAPPNLSPQIGKSENNEEEMPLIAPIVQHNGITHHEESTAQHYHDSMNAGPSTSSHVTPQMSMINTTPQQPPFSHPNSQQQATPGSGGVPSCGPAYTHHTPEQQSQQFMSPPMAGMPASVASNHSIHNSNSIEMVGGPASLQHTPQQYEMGHSMAQMSQESAIGGINTVPSIEQQNQLMLQHHQFSSPPAAPPPSQQQQVVQPPIPPAPTTANGRRRSESAATQRTKARQQHQHQQQQPQQPQQRIAAPGVPQGVHPQMQFPMNAMNMMPAYPPFYPYTNYPNIWQPPYQNYPYNQVDYQQPWLYNNGHIPHQTNGTATNQFHPGHMGYFPNNNGR
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MLSISCARIFCDNSLLSGLCDSIIVSRFESHESQIKASMSPTDNLSMTSDHRLVQSVDKGGKVTKVDLVVAQDGSGDFSTVSKAIEASKNRRTGTDKFVIFVKSGVYVESVIVNSTMPNLTLIGEGIDATVITNNKNANDGYETYNTATFQIWGSGFVAAGITFENTAGPEKLQAVALLSASDLSAFFRCSFKGYQDTLCLLQHRQFYRECDIYGTVDFIFGDATAVLQECNIYFRKPLPGQQNTITAQGRTDSSSVTGFVIHKSRVTAAAELTLANGWVRNFLGRPWRDYSTVVFVKCYLDSLIDPQGWLPYRGSSAFDKLYYAEYMNSGEGANTTGRVKWPGFHVLTSDQEAEQFSVGSFLAGDSWIPQTGIPFYSVKCLREKVINFCVCTHLVPFFFFCIQYTIELVVGVYHSPFDRLLTCDSRSKGYGEHKQQVRWYIEYKKKERDQMRTNATVGYPPDSFSVYSYTTNPTSSPTNINDFMRFILASLQNITYEMTLFMHVQLCNALEYLLGES
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEDEWLIVDADQKPVYKEAHQENCESLVALTGPPNSQPSEIFLIEDEEEPCIPEPGNKENKRRGNLCEGLGSEEEEESEEEDVQQQDHPKVVELDASMVPGNCKSLRWRVVQQVGGGKVLTGDGPPIMVLQKGYECEDCGKVFSCSSHYSKHRRTHTGERPFRCGECGKSFNVSSNLYRHQRAHANAGATPVTPAPSLLPSRGLPYQCAECGQCFRRNTELVTHQRLHTGRLPFQCADCGKSFSWSSHFARHLRIHTGEKPYPCNECGKSFSRSSHLYRHQRTHVTSAAANVTRAYICTYCGRSFSTTLHFDQHQRTHRGRKPYKCTLCGKAFADGLALVKHQRLHLIGGDQSHQCSECGQSFGGQSQLARHRRLHGTADKPYGCGECGQSFSSRGQLAQHRRLHMSADKPYHCGECGLSFTWSSHWERHRRIHTGERPYSCGDCGKCFGRTSHLYRHQRTHAGGQPHVCPDCGKSFNSTLHFQRHQHTHHLDPDNDSPSARACGDCGMPFADASALLKHQCVHEGERLYPCPQCGCHFRGTSQLYQHLRTHRPGDTILIPASPQCKEIEPC
The following text describes a protein:
Function:
UDP-glucuronic acid transporter that modulates the polysaccharide composition of seed mucilage. Transports UDP-glucuronic acid (UDP-GlcA) and UDP-galacturonic acid (UDP-GalA) in vitro.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSSSAKKQTLFISTLIISWYSSNIGVLLLNKFLLSNYGFKFPIFLTMCHMSACAILSYISIVFLKLVPLQHLKSRSQFLKVATLSIVFCASVVGGNISLRYLPVSFNQAVGATTPFFTALFAYLMTFKREAWVTYGALVPVVAGVVIASGGEPGFHWFGFIMCISATAARAFKSVLQGILLSSEGEKLNSMNLMLYMSPIAVIALLPVTLFMEPDVISVTLTLAKQHQYMWILLLVNSVMAYSANLLNFLVTKHTSALTLQVLGNAKGAVAVVISILIFQNPVTVMGIGGYSITVLGVVAYGETKRRFR
The following text describes a protein:
Function:
Inhibits SNARE complex formation by absorbing free STX1A.
Subcellular Localization:
Membrane; Single-pass membrane protein. Synapse, synaptosome.
Sequence:
MAMSLQGSRRASAGSRRRTSPPVSVRDAYGTASLSSSSNSGSCKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGVAKEEGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQAGDPSNTPAEDRADSGFVAADDTLSRTEALEASSLLSSGVDCGFEEASLHSSFNLGPRFPASNTYEKLLCGMEAAVQASCMQERAIQTDFVQYQPDLNTILEKVGQAQGCSSVLKDRHSELDLHPSGPRDPDSAVVVTVGDEPEAPEPITRGPAIHRPAVNSNPGLPVSVVCPVEEEEEAAAAAAAAAAATTTTTTTEKEPKSYWSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRRISCSLSQPSAGSSGGSQL
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MALHQYDWILALGTIFAFLDAWNIGANDVANSWATSVSSRSVKYWQAMVLATIMEFAGGIGVGATVSDTIRTKVVDVDLFENNPALLMLGMLCALVGSSTYLTFATRIGLPVSTTHSIMGGVIGMGVALVGADGVKWWGGNINSGVVQVFLAWVIAPFISAAFAAIIFLLTKYLILLRSNPARKALYTIPFYFFVTCTLLAMLIVWKGGSSRIKLEGNEIAGTVVGTGAVMAALAAFFLVPWLYRRVILDDWAIRPWHLLLGPLVLRRGEVPPRPEGVKTVQNYYRGHKTFEQIQAERAAGNDVETANKSTPATSTEGSPEIEPKADPRVLASEPDSEPDAINISGPRPEGGNFHPAVLFWQAKRLFFRGIEKDVVSMQNKRNILTGDIEMTHAHADHFENRAEYMFSFLQVLTASTASFAHGANDLSNAVGPYATIYSIWRTASLSGSGGSGKTDVPYWILAFGGASLVIGLWTYGYNIMRNLGNFITLHSPSRGFTMELGSAITIIMATKLKLPVSTTQCITGATVGVGLCNGTYKTINWRMVAWIYMGWIITLPVTGIISGCITGIIINAPRWGYQG
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MPITLKSANPSSGASNNLSLDVPSIVRSVIEDIRQNGDKALRSYSEKFDKWSPDSFKLSKEQIDEIVSTVPAQVIEDIKTVQQNVRTFAEEQRKSIRDFEYQIQPGVFLGQKNIPISAVGAYIPGGRYPLLASAHMTIVTAKAAGVSRVIACTPPIQGKIPASTVAAIHLAGADEIYILGGVQAIAAMALGTESINKTDFIAGPGNPFVAEAKRQLFGEIGIDLPAGPTEVLIVADAKADPFVVATDLLSQAEHGPDTPAILITDSRDVAEKTIKEVERLLPILPTRALAAVSWERFGEVQLVEDLNEAYKLADEYASEHVQILTENPREALVKMKNYGALFLGEKTCVSYGDKCIGTNHVLPTKSAARFTGGLWVGKYLKTVTYQEVTDAKASGELGRLCGRAARAEGFEGHARSGDVRAHNYLSDSFEWLAEPSGV
The following text describes a protein:
Function:
Binds preferentially double-stranded supercoiled DNA. Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
Subcellular Localization:
Nucleus.
Sequence:
MAGPSTTSNAPKQRKRVEAETSSNTSTTLRRAKDGSAFALCEGCNKSVAVALISMHNCSLDAKIRVNLEAQVVETQAEAKKKPAEKKKTTSDGPKPKRLKKTNDEKKSSSTSNKPKRPLTAFFIFMSDFRKTFKSEHNGSLAKDAAKIGGEKWKSLTEEEKKVYLDKAAELKAEYNKSLESNDADEEEEDEEKQSDDVDDAEEKQVDDDDEVEEKEVENTDDDKKEAEGKEEEEEEILDDY