lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region (By similarity). Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Domain:
Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity).
Sequence:
MANKNTSTTRRRPSKAELERKEAIQRMLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGSLAYLAIFGLLIYLFFFKWIRKQEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGTMAQVVTDLTGFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGSILILVGSLLVSPWSVYDIAEFFSRGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETEKALLDLPPVDMETGEILTEEAVQNLPPIPEEKWVEPEIILPQAELKFPEQEDDSDDEDVQVDFSAKEALEYKLPSLQLFAPDKPKDQSKEKKIVRENIKILEATFASFGIKVTVERAEIGPSVTKYEVKPAVGVRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDIATVSFRELWEQSQTKAENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASILMKARPDQVKFMMVDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYELFAKVGVRNIAGFNAKVEEFNSQSEYKQIPLPFIVVIVDELADLMMVASKEVEDAIIRLGQKARAAGIHMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLLGRGDMLFKPIDENHPVRLQGSFISDDDVERIVNFIKTQADADYDESFDPGEVSENEGEFSDGDAGGDPLFEEAKSLVIETQKASASMIQRRLSVGFNRATRLMEELEIAGVIGPAEGTKPRKVLQQ
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVKKIRKSEEIPNAAALAILRELATTTQLSEDQRKTLDYLEKVTKRTREESERIMRQLVEKFGFTRITAIQLVNLSIDSTEELKTILSHLERREFSEGELKEILKILTGQ
The following text describes a protein:
Function:
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
Sequence:
MKIFGTDGVRGKAGVKLTPMFVMRLGIAAGLYFKKHSQTNKILIGKDTRKSGYMVENALVSALTSIGYNVIQIGPMPTPAIAFLTEDMRCDAGIMISASHNPFEDNGIKFFNSYGYKLKEEEEKAIEEIFHDEELLHSSYKVGESVGSAKRIDDVIGRYIAHLKHSFPKHLNLQSLRIVLDTANGAAYKVAPVVFSELGADVLVINDEPNGCNINDQCGALHPNQLSQEVKKYRADLGFAFDGDADRLVVVDNLGNIVHGDKLLGVLGVYQKSKNALSSQAVVATNMSNLALKEYLKSQDLELKHCAIGDKFVSECMQLNKANFGGEQSGHIIFSDYAKTGDGLVCALQVSALVLESKQVSSVALNPFELYPQSLVNLNVQKKPPLESLKGYSALLKELDKLEIRHLIRYSGTENKLRILLEAKDEKLLESKMQELKEFFEGHLC
The following text describes a protein:
Function:
p43 is a 5S RNA binding protein which is a major constituent of oocytes and comprises part of a 42S ribonucleoprotein storage particle.
Sequence:
MKNVGETGPGKCQLLRCPAAGCKAFYRKEGKLQDHMAGHSEQKPWKCGIKDCDKVFARKRQILKHVKRHLALKKLSCPTAGCKMTFSTKKSLSRHKLYKHGEAVPLKCFVPGCKRSFRKKRALRRHLSVHSNEPLSVCDVPGCSWKSSSVAKLVAHQKRHRGYRCSYEGCQTVSPTWTALQTHVKKHPLELQCAACKKPFKKASALRRHKATHAKKPLQLPCPRQDCDKTFSSVFNLTHHVRKLHLCLQTHRCPHSGCTRSFAMRESLLRHLVVHDPERKKLKLKFVRGPSKFLGRGTRCRTPVVEEDLSHLFSRKLLFHFKTRLETNLSGLFNERQLREPAEPEVNLSGLFQRPQGRAKAEKSA
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Catalyzes both the GDP release by and the GTP binding to ARF2. Has no exchange activity on Rab GTPases. Involved in vesicular transport.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
The SEC7 domain is sufficient for nucleotide exchange activity.
Sequence:
MNQSISSLIKLKFLQSHSNDKNGNKKGGSNVSTGIDKLRESESYRSPFLQLAEIQEHTNNDDDKLDVKECEPTKKHSKLSRIRRKMGRLDLNFRSANEKGSEDDEILVAQHLRNGQDPEEMPFKSENNIDSIEKVPKPDGERVTLTSSGSDNVKRNSKHAPFIPVKPALEKFPSSNRLSRDYRKSQEPTLFNGDRLVPTLPTVSRISTSSSVGSSTAASRYFNPSKRAVVASSSSSSSSIKFNSLHAIPLDATPQIELAKQQDEISKRRFGRRRSRTVDVFDYINKNNTAKNKPPLSPSSFIRTIDEKNTNSLMQDPMGSRGPLLPDDANIISNDTDGAEASHPDHQVLSRSRSQSTSFVQGKGGKRKSIEDEGYHNKLGLPHGSGPTSVYNNKSNANSTITGMSRRSSSIVNALSSFVNLRSSSLSSSRQQHLQQQQQLQQKLDVSLEDLPPVPAPEFSDSCKDFLIKLAPYGKFIGIILTEKDDEFKKNCLNYLLTNCFEFKNDPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKGIECPWSNADQVYFIAFSLLMLHTDYFNPNNKSKMTKHDFVDLVHNDKYSGGNEIPMAVLTYFYENVTAKESPKFNYFLMSPMALDDSILDKDAFDTNFAITLSSNSMYSPIDMIKRGSIIPKEASLSPIFYPLTNSISASGIAPSTAASCPPSTSGTINGANLGTANSNSNRPASNSISSYFSYNPSSSSSGNATLVQDDINVYSHIINDTLNEVNLFPEVSKYWNKNALKANLLRNEEHKYEKYYSIMNDTKGGYLRFHKSQLNKLNLPNFEILNDNSRSGCKNSDYKYCKILQMGAIMNLGMPSRKFSIVNSAKIHWKKEFAILTSLGLLICDKMDWINPQMMKDPKSGTTNYIIDFKSGFSFVPGSTIDVYNGLFADRERDSLGKSHFASLVLAYTEHHSTGSHTSNTTAASSSAKHNEGVFEPSSDEEDSITNSTDGTSSVSNGESDNDSVSSSDNQLSSNDSNEDYHSIKDEYPIFEDENADCLLYLHTCHRNFIWKCANKYERDNWIDSINLFSAYDGCYVEIGSIANTICNKRKLTILQRMERLRSIKSAKWEKLKKFESTLMLMGKCVPISTKTKTDMINRIRQLAVRMDWLIYEIKRSELFVSIIKEVTRKQAEKNILEHGKGEEEGQGNNDDSDGIDDIEESFLFNENSLQVCVSDSSYDEYSNE
The following text describes a protein:
Function:
Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.
Subcellular Localization:
Nucleus. Note=Localizes at DNA replication sites.
Sequence:
MAELLPGYSPSFKKPSEILRLSRRRSRSEASKAGVSPFSPGDVTKRVPGLRPFSPGPNKGAGVKRRNPFANLENTVCSPVKRRAESVPECASPEPRALVAARPSCWELGSPSPQPPQFNSVEDVIWGDPLADPLVKTESPEKPATACETPKGSVTFPADWSLKTRLLFTSSQSFSWADHLKAQEEAQGLVMHCRATAVSLPHSIQEPKLSTELRCAFQQSLVHWVHPSFPWVQLFPRIGIDRKMVGKNSPWSHDESLQQVIMSEWALSFTSLYNLLKAKLCPYFYVCTYQFTVLFRAAGLAGSDVITAVMSPTTRGLREAMKNEGITFTQPLVEEDPSKKQKNSEANSQGDITPKKENGNTETDEVSDESDEDESFSWLEEMGVEDKIKKPDSISIKLRKEKNEVKLDHKPESVVLVKGTNTFTLLNFLINCKSIVAAAGPQAGLPPTLLSPVAFRGATMQTLKARSVNVKTQVRSGYKDQFSLEITGPIMPHSLHSLTMLLQSAQRGSFSAGFYSHDPTAVFNTPIHPQAAKEISADLQNCGLHPSTVEQLSQVNQLGKLSLRHLELSDYRYTWKS
The following text describes a protein:
Function:
Structural component of sperm fibrous sheath. Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=Dorsal margin of the acrosomal segment. Ribs of the fibrous sheath in the principal piece of the sperm tail.
Domain:
RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence:
MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKMDTSTDPVRVLSWLRKDLEKSTAGFQDSRFKPGESSFVEEVAYPVDQRKGFCVDYYNTTNKGSPGRLHFEMSHKENPSQGLISHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIHGAENKCVHQSLYMGDEPTPHKSLSTVASELVNETVTACSKNISSDKAPGSGDRASGSSQAPGLRYTSTLKIKESTKEGKCPDDKPGTKKSFFYKEVFESRNAGDAKEGGRSLPGDQKLFRTSPDNRPDDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLMKHAKEVVSDLIDSFMKNLHGVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYNVMFAKKFPENIRRARDKSESYSLISTKSRAGDPKLSNLNFAMKSESKLKENLFSTCKLEKEKTCAETLGEHIIKEGLHMWHKSQQKSPGLERAAKLGNAPQEVSFECPDPCEANPPHQPQPPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQSFLEAAASTNFPTNKPPPPSPVVQDECKLKSPPHKICDQEQTEKKDLMSVIFNFIRNLLSETIFKSSRNCESNVHEQNTQEEEIHPCERPKTPCERPITPPAPKFCEDEEATGGALSGLTKMVANQLDNCMNGQMVEHLMDSVMKLCLIIAKSCDSPLSELGEEKCGDASRPNSAFPDNLYECLPVKGTGTAEALLQNAYLTIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSATAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL
The following text describes a protein:
Function:
Involved in the maturation of the nickel-dependent guanidine hydrolase GdmH. Required for nickel insertion into the metal center of GdmH. Seems to be required only for GdmH activation and not for activity.
Sequence:
MHETDMTKALIMTIQDWFDQQVEKPQITKIHLLVGQFTCVEPVSLQFAFEVQTKQTFLNGAELVIKDVPLVAYCHTCQTEYSPEIGLQYSCPTCRSPMDDIRSGRELKIDRIEHHQCTPA
The following text describes a protein:
Function:
5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus.
Sequence:
MARSSRYLRRLQGPLLPPKDLVEEDEDYLNDDVQEDEDSVFVDAEELCSGGVKAGSLPGCIRVLIPDENTQETCKVLGRFPITGAWWRVKVQVKPVVGSRSYQYQVQGFPSYFLQSDMSPPNQKHICALFLKECEVSSDVINKFLAWVNEVSNYKNLNFENLRETLRTFHKETGRKDQKQPAQNGQEELFPDNEMSLPLENKIPYRNVMTALQFPKIMEFLPVLLPRHFKWLIESGSKEMLKEIEEILGTHPWKLGFSKITYRKWKLLRCEASWIAFYQCESLLQLMTDLEKNALIMYSKLKQICRELGHTYVEVNDLTLTLSDHMSFHAASESLKFLKDIGVVTYEKACVFLYDLYQAERAIAFSICDLMQRPPWRLCVDVKKVLASIHTTKPENSSDDALNESKPDEARLENPVDVVDTQDSGDHIWTNGENEINAEISEVQVDQDQAEVPLDRDQVAALEMICSNPVTVISGKGGCGKTTIVSRLFKHIEQLEEREVKNACEDFEQDQNASEEWNTFTEQSQLEAGKAIEVLLTAPTGKAAGLLRQKTGLHAYTLCQVNYSFYSWNQTMMTTNKPWKFSSVRVLVVDEGSLVSVGIFKSVLNLLCEHSKLSKLIILGDIRQLPSIEPGNLLKDLFETLKSRNCAIELKTNHRAESQLIVDNATRISRRQFPKFDAELNISDNPTLPISIQDKTFIFVRLPEEDASSQSSKTNHHSCLYSTVKTLLQENDLQNAKTSQFIAFRRQDCDLINDCCCKHYTGHLNKDHQNRLVFGVGDKICCTRNAYLSDLLPENISGSQQNNDLDTSGEDFSGTLHDFAKNKHDFESNVRLCNGEIFFITNDVTDVTFGMRRSLTINNMAGLEVTVDFKKLMKYCRIKHAWARTIHTFQGSEEQTVVYVVGKAGRQHWQHVYTAVTRGRCRVYVIAEESQLRNAIMKNSFPRKTRLKHFLQSKLSSSGAPPADFQTPRKSSGDSGGPSTPSASPLPVVTDHAMTNDVTWSEASSPDERTLTFAERWQLSSPDGVDTDDDLPKSRASKRTCGVNDDESPSKILMVGESPQVSSRLQNLRLNNLIPRQLFKPTDNQET
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MANQLQVPKQKLAKPPLAIHTLGDRVLRQGSKQISGINDEVRKLAQQMLQTMYSADGIGLAAPQVGVNKRMIVVDIDPENAARPPLVLINPLIKQFSSDLAVDQEGCLSVPSIYADVRRPERVVATYRDLNGRPVTLEATGLLARCIQHEIDHLDGVLFVDRVENQIALAPQLVEKGFAVRDVQVRA
The following text describes a protein:
Function:
Transcriptional activator. Activates transcriptional activities of SRE and AP-1.
Subcellular Localization:
Nucleus.
Sequence:
RQSEDKSQFGFAAKMLSEQTAALGTGWESMNVQVDRAEPQVERGSQEEGPWRTAPGPLEHLCCDLEEEPQSLQEKAQSTPWVPAIPQEGSTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWVPDPPDLEERDILKVTYTGDGSEHEGDTPELEAEPPRMLSSVSQDTVLWNPEQDANWDSMPRSSRGMLLGPPFLQEDSFSNLLCSTEMDSLLRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKSFGRRHHLIRHQKTHLHDKPSRCPECGKNFRCNSHLASHQRVHADGKSCKGQEVGESPGARKRQRAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFQCPRCEKSFGRKHHLDRHLLTHQGQSPRSSWDRGTSVF
The following text describes a protein:
Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue.
Subcellular Localization:
Nucleus.
Domain:
The TDP domain (123-605) is sufficient to confer the full phosphodiesterase activity.
Sequence:
MAHSQVAYLIPLKADLKEDNSSPRITLSEGPNIIGRGNVSIVDKRLSRKHITIIVSTSGSASLSVDGTNPVVIRSSGDGERKKVKPSEEVSVCNDDLIELIPGHHFFKLVLLNGRAAKKARKAEDDVEAIRRFCPPNEKLPSTFRLLSVDALPDWANTSCVSINDVIEGDVVAAILSNYMVDIDWLMSACPKLANIPQVMVIHGEGDGRQEYIQRKKPANWILHKPRLPISFGTHHSKAIFLVYPRGVRVVVHTANLIHVDWNNKSQGLWMQDFPWKDDDKDPPKGCGFEGDLIDYLNVLKWPEFTANLPGRGNVKINAAFFKKFDYSDATVRLIASVPGYHTGFNLNKWGHMKLRTILQECIFDREFRRSPLIYQFSSLGSLDEKWLAEFGNSLSSGITEDKTPLGPGDSLIIWPTVEDVRCSLEGYAAGNAIPSPLKNVEKPFLKKYWARWKADHSARGRAMPHIKTFTRYNDQKIAWFLLTSSNLSKAAWGALQKNNSQLMIRSYELGVLFLPSPIKTQGCVFSCTESNPSVMKAKQETKDEVEKRSKLVTMTWQGDRDLPEIISLPVPYQLPPKPYSPEDVPWSWDRGYSKKDVYGQVWPR
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MSGGRRRGGAPWHSFSRFFAPRSPSRDKEEEEEEKPGTSQPPAPGRGAASVENEPMSTSQKKENVLSSESVKIPQSEDKRSHAEKLITLPAQEDSKKPNDLSGSTSDAKIGESDKQPKESFFQFLGNLFNISGKSSLSEAKQSSFKDEHDKTEKDLQNPTEHHEEGVHRERATVSGSLETQVLPAEQESNSAELSDAFSLDTAQDSEQETSDLLRQIHDKPEKPLVTFSTYRGPRQIRKYLKQQSASETVNPSDRENESSDSSGSTQMGPESEMEPGIVPVSSASTDISMKGHLLEGLLEVSDYNKINLNTEGHSRNHQELPNTASSKDVFNKNDPEGPERSRSSSSVTNSSPTLGESDSQHHFNCAPVSQMDRNLVCSTLFTGSKSSKTPCSPDLQRTASPETMIRENISVVSDGTVVQREEHAEPESPAVSDFSCSKSNGNDTTKQRSADLPSPNKSIRREDLQLPESKCSDKQTIDNSSKQAANHTNTVALQRHAVTDTELGNEGNGLSSQDTQENLAVTENKQEAESASVGEPTTSSHVKESRIESLPKDTDQPLVTEAIKLDFRPHGKMPSIGINQKDPASVKYTGESAGIACLENEIAPRLNFELNRDCISESLLDSERPQQAKVLPDVRTSLNLDHKKTDFNTSFPTFVSGVAVMNKLDIPVLKNKDSSVLIETGDVNIVGISSQPSKRQEENVADHVEAMDRENLPACLHPKHASAVLEYKEVLPDSEKCQFPLDLKASDTHLTAVDLSFKSESLFKDHSSISSQDPNKTELMLANTKACKNTLERPDSSFSLETKADNIAEILSKTEVSGQNSVPIESHSGRGKTLDSSKIPVSQIEPRHISQDKISSLLEIIDVPAKPMLTELISLEVEQDKSFQSLDHKDTKEKYPDAGLKENCQTEVSPSVSNHQGIQEMEVEALGGPPALLQSDRPEILPPVHDKKVTRQMAQNCEANICAIHQPLVICGTKNISGFSEMAELSLTNTSPKFQETDSMKVSSPLLSSGISLEKNPFASEGSSFLMNASVLRSPKKVSSHRKKENMHFPSGGTDIMSLSSVNSGEVSKVIRSHNHPSNFDSVKVTIEVTHEGASLTNPLYPNSSYLEVETSLPTGAEVTPLQDHLGSHPETVSLDFPTAAQFDNPMETETGAVAGAPVSVNSSSWQCSEASAKHIETRRRAHDQFLDLKSGLHKKAGTLIGEIFDSVTEELKSKHTVGTLEEHTATDGIMNPGTLKEDIPSEVTLPGIQLTEHFEEQLMENMSEVQGEEKACVSPVVGEKSLLFDSDRIDVSWLLEDQARELVNEIIYSAQETLTNDAEDAWDSELQTNTSEILNSDDVKPDDRVREFLVSEQTANQSTCEISEKVLGRFFAVNNLVSDTESIKGREIGLYQNSPFSENRAGQSDSINLQESDAILLAEDMPHTGLAIKAETHSFLHKDSKEKMEIECVDNHKTETEDTRTSKSILSNALVCISEKSFPEHSNKSTPLTTSEVGQVHKEDDEVYIGERELIPSMLEAEKTNKKDAELNIVKYDAVPPLSEMGRAHKRDAELSISKTEPTADILKMREAYQMGTERCIEKTERLPATLEMEKAYKIRDTKGDIGKTDMTTLMSELKNVYQKDAEGITGKTEVIPATLEMESIYQKDAEGDIAKTEVMPVPLEMKSISQKHAEGDIGKTGMTSVMSEMENIYQKDVEGTAEKVEMIPATLEMEHVYQKHAEGEVDETEAIPIMPIMVNVYQKEGEEIPAKTESPVLDTENTHQKDAEEVIRKTKIIPPFALKVKEAHRKAVPASLEMDETCKRDAKETIGMIVSVPSKIEMERTSPEDYDGAVRKNRVLSTVVNVEKTHETGLELPITQVEATPPIFEAEKAPQEYAKGSAGETEKEPTEMKAGLIACDSRLASYFKGYESPTLSKDYEGYPALVQGFQPEDTVGRLDRRTSVTAVHKQIRDLGYGNEKEEPNLAFISQDEQENSSFTILYEEPLQDEDKYATAEVRRTHSHIIPDTSTDSMTVFTCERSESRTDLIHHFEKETKLGETFESDSSEIFLSVEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHYGSTKSRESADQPSSVLSLLQSVSERLKMNFGEDDRREGWEEENEEEEEETFHKGSLRARRQETVTFKLPDSSITFYPDDGQESTGISKNSYVMSNEPTTSNLQIGLWPEKASFLQKSDLTSKLHSSLKSAYHQYLQTSKTHSSEKGARFGGTFQEPVSKYFRVQDTSGQLSTFTENVDKQTLRCNPRPGKMVIYDLHGSKYKQEIYCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFQGQKCVLEEGEKVLNRDWILQNKKHPQRNFVLGSIRRVLKDCSIPEIELCPQSDPARCPIYIQRAVPNLEELNIPKSVSFTVKSGVWLAYPDINFKGQATVLEEDHGLFEVSIAEVKSLHPLQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNDVDFHGIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSNACGALSGSILSFRYLQANFIESSITLFESDLESGKFINITNQEISDLEEIGFGSETRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPVQLEPLGINEPPHLLKAFSKPGFQGECIDFTKEISDLPSSFTPCSFKVLRGCWLMYYQEDISNNQCVLEEGLYADLTSCGCPTSRVISLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLEPNEIPNWTAFSGWKTIGSLRPMKQPAVYIRIKNRAQDEYLTVTGNVADTRATSVCISPYSGKNTQIWHYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQLRQKWRLNRNGTISSYLSDQLVLDVKGGNYYDKTHVIVNQPLEGEETQKWDIEIL
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MPEPLGTTALTPGFMIVHGNRLDDLRDLAVSWMRRYPLAPLESERVLVHSNGIAQWLKLALAEDPREDGGGGGGIAAALEVQLPAQFLWQAYRAVLGRESIPEVSELDKAPLTWRLMRLLPGLLERPEFRTLQRFLADDADLRKRHQLAERLADLFDQYQVYRGDWLDDWSQGRDQLRTANGQARPLGADERWQAELWRALLADVGADSLARSRSGVHRRFIEALRSASAAPRALPRRVVVFGISSMPAQTLEALAALARFSQVLLCVHNPCRHHWADIVADKDLLRHEYRRQQRRAGVPADLDEDRQHQHAQPLLAAWGKQGRDYINLLDSYDDPDSYRNLFGEVNGGRIDLFSEETPHGLLGQLQDDILELRPLAETREHWPPVAPRSDASIRFHVAHSAQREVEILHDQLLARFNADPSLKPRDVIVMVPDINAYAPHIEAVFGQVPRDDQRFIPYTLADQGQRGREPLLIALEHLLKLPDSRFAVSEILDLLDVPALRRRFGVDEADLATLHRWIEGAGVRWGLDAAQRERLGLPAGLEGNSWRFGLRRMLLGYAVGEGAALQGIQPYDEVGGLDAALAGPLAVLLERLEVAYAELAEPATPAQWGERLQALLTVFFEAHDERDELLLTQLLQLLERWQEHCACAAFAEPLPISVIREAWLGGLDQGGLNQRFLAGAVSFCTLMPMRAIPFRLVCLLGMNDGDYPRQQSPLDFDLMRNDYRPGDRSRREDDRYLLLEALLSAREQLYVSWVGRSIRDNGERPPSVLIGQLRDHLAAGWRLDPDGDGEALLRALTQEHPLQPFSRRYFHDAPEQGVDGLFTYAREWREVHREDEIGVPDAEAPLPPLELEGALGLRALAEFLANPVNAFFQQRLKVRFDDEQLTGNDEEPFELDALDNWKLQFELTERMKRWVERDWDAEGLPVQLQAQVERLRRQGRLPLAAFGEFSARHLLQPLPDLLWRYRQEIERWPEAVEQQQELRHRHPSGLELEDWLGGLRRDASGRLARLQLLSGKLHEGRSFKWHSLVRHWLQHLALQRLGQPVSSVLVSQTGTLEIPPLPSERASEYLDQLIDAWRQGMRQPLPLACRTAFAWLASGGAAEPEKAMREARKRYEGGFGMGGEVDASPALARVYPDFDRLLASGEFAHWAEQLYAPLLAALGRGAEEQA
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Sequence:
MPIVKLVILGSGGAVPKADRMLPAIYLEDWLGHRVLLDAGEGVQYRLLQIGISPSSLTLIAVTHMHEDHILGLPGLVITSKFLGGRLKVLAPKSMHGALSKLGVEVADSYEEERFKIKCVEVCHTVDACGWLIQWDVGYKLDLSKTSGLPKWALTELIKGKPVKIGDRIITPEEVADPAHKRFKYLLYTGDTAPCPEMWKKVGSVDVLIHEATFADDVSPSKAHEEGHSTVADAIEAARALNAQVLILTHVSARYPDKSRHRELASRISPPPYIYIPEDFETLLVKL
The following text describes a protein:
Function:
Binds and transfers [4Fe-4S] iron-sulfur clusters to target proteins.
Subcellular Localization:
Plastid, apicoplast.
Sequence:
MNCIFLSVLFIWYFFFVYVKNLSILQYDKAKVLFIQNNFEPLNNNMLRVPLNILRKRTYVVKNKKNGVPFQIFLSSENDEGLYYELNPENVEKVLNLIRPKLQIDNGDVELVDIKNNDLYIRLLGNCVTCSSNSITVSHVIKKTLKMYIRNEQNQEPNVIITNFDEINEQNIQNCLSQLKPYLDFLKVEVIIKELVNNKENINNYVCLKFLNIENSSEEINIPHNVKNEITERLKQKFPTLTVNFEN
The following text describes a protein:
Function:
Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities, and in the production of gibberellins phytohormones. Catalyzes the conversion of ent-copalyl diphosphate (ent-CPP) to ent-kaurene.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MNLSLCIASPLLTKSNRPAALSAIHTASTSHGGQTNPTNLIIDTTKERIQKQFKNVEISVSSYDTAWVAMVPSPNSPKSPCFPECLNWLINNQLNDGSWGLVNHTHNHNHPLLKDSLSSTLACIVALKRWNVGEDQINKGLSFIESNLASATEKSQPSPIGFDIIFPGLLEYAKNLDINLLSKQTDFSLMLHKRELEQKRCHSNEMDGYLAYISEGLGNLYDWNMVKKYQMKNGSVFNSPSATAAAFINHQNPGCLNYLNSLLDKFGNAVPTVYPHDLFIRLSMVDTIERLGISHHFRVEIKNVLDETYRCWVERDEQIFMDVVTCALAFRLLRINGYEVSPDPLAEITNELALKDEYAALETYHASHILYQEDLSSGKQILKSADFLKEIISTDSNRLSKLIHKEVENALKFPINTGLERINTRRNIQLYNVDNTRILKTTYHSSNISNTDYLRLAVEDFYTCQSIYREELKGLERWVVENKLDQLKFARQKTAYCYFSVAATLSSPELSDARISWAKNGILTTVVDDFFDIGGTIDELTNLIQCVEKWNVDVDKDCCSEHVRILFLALKDAICWIGDEAFKWQARDVTSHVIQTWLELMNSMLREAIWTRDAYVPTLNEYMENAYVSFALGPIVKPAIYFVGPKLSEEIVESSEYHNLFKLMSTQGRLLNDIHSFKREFKEGKLNAVALHLSNGESGKVEEEVVEEMMMMIKNKRKELMKLIFEENGSIVPRACKDAFWNMCHVLNFFYANDDGFTGNTILDTVKDIIYNPLVLVNENEEQR
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence:
MNIFSNEDLNIYLKSVREHKLITHEEEIKLAGQIQRGNAKAKNKMINANLRLVLKIIKRYAGKGLKIEDLIQEGNLGLIRAAEKYDPNKNTKFSTYASFWIKQSLQRALNTKTRLVKVPYRKENLILQINKYLTEEEKSPKKEEIMKRFNLSPAQYIKIIPYLEKEYSLDKEIEGSENSTLLNLYEDNSFNPEITLEQDSTLKHLNYILETKLNEKERYIIKKRYNLDNSPKKSTLKDISTELGISSETVRQIEKRVLKKLKEEIN
The following text describes a protein:
Function:
Has a role in cell separation, a final step of cytokinesis and in the assembly of the forespore membrane. May have a role in the transport of secretory proteins to these growing sites.
Sequence:
MKKLFKKKKGVSPHMYMLPEESNSNTATNAPSYSVGGTTANSYSSNSYNDNNNSNSTYGSSNNYGNYGSSNNYGSYGASNTYGSNGSSNNYGNYGATNSNGDAGYSITPIRNDPYARKDMPPMKSSAAVTERPSMHRSAPSQDTLDLKKQELFAGARIQNDDESTTDTIPHNDDGTEGDEYGEGYRDGYEEDQEVEAIKQKIQFVKQDSLSSTRNALLMAGNAEQMGLATLANLGEQTEKIATAEKELDISKIHAKRAEEQARELKTLNRSMFAIHVPKPWGKAKRVAAEEARLAAKRDAERQDEMLNRQFAYRSQKRIDQAMKDNMKSNKKKGDSKGVSILERSHYQFEPDAEDDAMEKEIDGNLDQIGALATRLKGLAYATGQEIDSQNARLGSIHDKSDRLDTDVYLNVERLRHIH
The following text describes a protein:
Function:
Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDITCGRQTVHKDATMYPLSVRSTSNNHTAQNYVSNQPYFNYVAYHHVPPMDDQGQPMEFGDSVWITEGGMELLWSWTLTQIWHKSSDLSPNQFAYNSSGYSSPHPSGTGILHSVDLTHAAANSPSALSQNSYEWMGKTVQSTSTGKTRTKEKYTVVYTDHQRLELEKEFHYSRYITIRRKTELAANLRLSERQVKIWFQNRRAKEGAIQEENEPSLWLCSVQSDSSSASPNPLCDSAVHTDMSGSLYQPATPNCTQWPIARAGSVCKHVTLSQ
The following text describes a protein:
Function:
Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.
Sequence:
MTGDWKNRPARVQLQESDLPSSVPPQTGLAFNVWYNKWSQGQSGSTRFVTPYSLDPENDSGITKGDKEGRIHFCLYFAKGMCCLGKNCRYLHHIPEPDDFARLALHSSALDCFGREKFADYRDDMGGVGSFKKPNRVLYVGGITGALNNKTLKPHQIENRVKYKFGKLGELDSVRYVESKNCAFVKFKLQCNSEFTKEAMGNQTLLIPTDKEWDLRKEGTGLLVKWANEDPNPAVRKRELEEQTQETLKAIKQLVASTEGTVNQKRKVEEINEVRDSQANSRERFSIRENAIIDKTILDKLKQRKVTITNTNVAANITVSKPSSVLPLVTQYSSDED
The following text describes a protein:
Function:
Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively.
Subcellular Localization:
Cytoplasm. Note=Enriched in synaptic boutons.
Sequence:
MFKFNKAAQQQRIDNRNSAVTGHDPFVRPPVPEKKVRNIMKKLHKANGLKRSNSAIEFDVSALTAANRRQIYSSNRSASSEQDNSDLSEHSEKSPLVSARLDNLARLFFSKSMPAETGSRDTIDSVLTTRPNIKYQYSALDSGNGIVERSPRERAQREKALNATQEWIQGANGRYEVIAHLDEIGSRHGKNWFLVTDASVRTDRLQTLLPLPPDCVAFEDLPPNECAREILMELLGSLHHPYIYPVLDLGFLRNSSYNYACLVTPFNSRGSLKDLIYKAQWNEPWARKYTRKPNGLPVSQVQRLGRQILEALLFLKERGFPLHGHLHSGNVILQNGAARLSGLENGLLGLSSRINAVMWSRSVTEIENVDIVCFGHLLYEMCTGQELTTPKPSMRVLEMELQHYPQIGQTRKQILEILGLIFEPPSGVCPSVEDLVLCDLFRSIDLRELRGPCFSTIKPSLSRSTLNLLQAVKKRQCASLGHSLSEANSPCTPPSTPHDRRTGVLPAPYEVFRMY
The following text describes a protein:
Function:
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.
Sequence:
MTSTSKAVELQLQVKHNAEELQDFMRDLEHWEKTMRQKDLELRRQSGVPEENLPPIRNGSFRKKKKRKTKDSSKKTKEENTKNRIKSFDYDAWAKLDVDSILDELDKEDSTHDSVSQESESDEDGVRVDSQKALVLKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALSRSYTKAYARRGAARFALQKLEDARKDYVKVLELEPDNFEATNELRKIDQALTSKENSHPKDIAAVIKPAEGERKANEDQRGRQKAIAEKDLGNGFFKEGKYEQAIECYTRGIAADSTNALLPANRAMAYLKVQKYEEAERDCTQAILLDGSYSKAFARRGTARTFLGKINEAKQDFETVLLLEPGNKQAVTELSRIKKELIEKGRWDDVFLDSTQRHNVVKPVDSPHRGSPKALKKVFIEETGNLIESVDAPESSATVPESDRAAVAVDTGRKKDFSQGDSVSSGETPRAKVLKIEAVGDSSAPQAQVDVKQGVRQSVSEKTSVRVAQTPGQLAAVVLPPVPANSFQLESDFRQLRSSPEMLYQYVKKIEPSLYPKLFQKNLDPDVFNQIIKILHDFYVEREKPALIFEVLERLSQLRRFDMAVMFMSGTERELTKVLFNHLEKSELKEDSVEELKKRYGGG