lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MEEFGSITHIDSHLKEVPCGIVVEAKPLSTAHRVNGVNRFLEISSRLAVLLLCCKNYSGLRQETKKSDMGSISCCSVDCGRLTCRINPPAMQGVTVTSSPAKSYTIKDRIAQIYYKHGLYCSSHPLTLISFAIFTFLIACYPLLHIPLLGSSSQQFSTPIALYSAELDEDSQTIGPRWGPPVAYVQQVVVKAAVSPWQQSLMLMDAFRSPLAESFHLTELINNHQFVDRQGCLPLAYDIEHANNSTVHTLQDMCMQVSEPKDKVAATSLPQFGCLTLSPTYVWKQDYNSNSTVHTLQDMCMQVSEPKDKVAATSLPQFGCLTLSPTYVWKQDYNSFRHDSQILMSIFDLKDETSDSYYLREILFGVPWKETGIKKLCVRNRQRVITFAVTMVLKKWDPDIMHSLEDKLRQAYPSHSHNSSAQQRDQREIVHVHFQYQHTLAEFVPLGTIYFVLFFYIYFSVRKIELVKSKWAISVSAVLTVVMSLFMSVGLCLWFGLNPTLNGSPLVSPRSSCLPSEILPYLVVVVGLENMLVLTKSVVSTPVHVGAKVRLAQGLSKEGWSITKNLLTELLLLTFAFLTFVPAIQKFDLKKGRSEASNTWTGEDKNLVNTDTRNSVGVLYRSRRSDGVPVVTYGSNRAMSRIFATPTSPILKLPKRLRLVYFWARMRLIQRGLMASLAGLGLVVWIVVLIHSMGIVGKFTDSTGNFGPNLAESGSSRLESTESSSAGTWKCIVTAGTLTEEQVQSSPGGGLVHPASRAEATLVLALSIPTVLFIVYLFVTLYRCMCSRNYAEWRTSWSTLYPSGCQDPDTFLVMDTYPIELRGHSQPGASAAVSGCQDGVVCVWDLMTGTCAYSLTAHRGAVLALRTTGLYMLSLGSDSRLRIWEKSQGHLLHTLYQANTLCNNMALLSDNIVVTAKE
The following text describes a protein:
Function:
Probably a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta-like daf-7 signaling. Plays a role in TGF-beta-like daf-7 signaling in regulating entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions; partially redundant with R-SMAD daf-14. Plays a role in inhibiting mitosis and promoting a switch to meiosis in the germ line, perhaps by down-regulating lag-2 transcription in the gonadal distal tip cells (DTCs). In cooperation with orphan nuclear receptor nhr-69 modulates the Insulin/IGF-1-like signaling (IIS) pathway, perhaps by regulating expression of the potassium channel exp-2, which in turn modulates the secretion of the insulin-like peptide daf-28.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the nucleus in a TGF-beta-like receptor daf-1 dependent manner.
Sequence:
MDDFPSPEPTDPRLEAMAQKVLEETIITEGDGTIYWALKVTRLLSRVAKKHQCFEAFYDAVIKGDPKTRCCPAHNEKLIGNFGRAIMCVLRAFRFPVIRYESQVKSILTCRHAFNSHSRNVCLNPYHYRWVELPTCQVPPIIVNKELDYGEPPIRTEDALDDWNQKDLKEEQVVASWDVPNVTMRGDEIKLLYDRYAAENGDFQYMNYGNFGSFDGSPCSSTTMSLGSSFASLLQQSNRQDDEEPGYYRSGLSSPASHAASPREFIPNGNDTISLDQEMMDDSEVSDIMHSENFSSENNGNRKPTYADGRPITPIEPRPLYRSSALELGDLSRQAGIYECVEYEESPSWLKLIYYEEGTMIGEKADVEGHHCLIDGFTASRTDSETRSRFSLGWYNNPNRSPQTAEVRGLIGKGVRFYLLAGEVYVENLCNIPVFVQSIGANMKNGFQLNTVSKLPPTGTMKVFDMRLFSKQLRTAAEKTYQDVYCLSRMCTVRVSFCKGWGEHYRRSTVLRSPVWFQAHLNNPMHWVDSVLTCMGAPPRICSSRT
The following text describes a protein:
Function:
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers (By similarity).
Subcellular Localization:
Membrane; Single-pass type IV membrane protein.
Sequence:
METYEQEYRLLRADIEEKLNDLSKSGENSVIQSCQRLLNEIDEVIGQMEIEITGIPTSERGLVNGRIRSYRSTLEEWRRHLKEEIGKSDRKALFGNRDETSGDYIASDQDYDQRTRLLQGTNRLEQSSQRLLESQRIANETEGIGASILRDLHGQRNQLEHSLEMLGDTSGHLDRSLRTLKTMARRLAMNRFFTTAIIAILVILILLVLYSKFR
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).
Sequence:
MCPPEQPAKAMAPSKSNQAAKSAVPTKEEKSADLVMATNNSSIVSKRSVEMLYYPEPHFFCHFVKKPQRRAPLINRGYWLRMHAMEESVRRFMRESPDKPKFVLNLGCGFDPLPFILLSADRSLCSQTTFVDIDYEKLMLNKKAALREAGALTQILEDVEFGPDESAVQIRSGQYVAVGCDLKNLDKLDRVLRAEVLPAECAVLFLAEVSLTYMDVKSANAVVSWASRLSNDAQFCILEQYFPDGPSHPFAATMMEHFGKLGAPLHSIHEFPSLSDQERRFTEAGWTHAHARSLWDLWSDDEFVPAVLRTSLDSIESFDEWEEFALFASHYFLLHASTRPGTKGSKSAAATADVGPSRQAVTRSNEFRLIPNTSLPTGQRRFGALVPGGEAVIGIHSGWGRQTRVADTDVYKTSKDNIDSHARFPSSNDISARLCHTITAFSDDGDCLLVGGRTSPASALQDTWVRKNNVWQAGSSLPLARFRHCATRVTLGSDRSSGSVLIYGGKTSDGTTLDTWLLWNDNGEGWSSVTVRTMNDAPAPKARFGACLASIDSTNGLLFGGIGPDGTILEDFWTWKLYEEADGSLCMELTDQTGSLRNIALGFDILPRFGATVSSTAQGLVVSGGIIPRRVVPFDGEILLLDSATLLDCIKNGLPLTTPILSTIGLDAGFTGPRPLLVGHVSHAISTDQVLLLGGGAVCFSFGTFWTRGTWMLCPVGERAVNDWALVCENVEKPTKAKAAAQIPAKTKKQKASKKYKPEKYKSTTKVTPIRRVTVESADEFQQILEDAQPVIIESADIGPCTELWTKEYLVNTVGSDRKVIVHAAETETMSFRTKNFKYESKTFGTFMDEVHAGGRQYLRSISEKQPAKLPANLAADFPSLSSDFRLPEALKTVVENAHSSPLRISGPVTLWLHYDVMANVLCQIQGEKRLILYPPSDVPHLDVPAGASSSNINVFQNRADGAIALIPHTSPHEARLKRGDILFIPPLWLHTAAPTGKVSVAVNVFFRNLSQGYALGRDVYGNRDVQAYEKGRKDLEKLVKSFSGLPPDMARFYLLRLADELQETAEQ
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MEQHFYVLSESDIKRLQDADINHLSSILFVSRPVACLLLSHYNWNVTQASESWFDNQQKVRNAIGLSNETHIELGLAYSSHTLICGICLEIFSSEAIRSSWCRHSFCINCWNQYVDTHIDDHNCFKLKCPEPSCNAAVDEDMIQQLASESRKIKYDQFFFRSYVENNNNMKLKWCPAPDCCNAISYELPYHHGSSSSRINYDVTCLCYHSFCWNCGEEAHTPVDCEIVAKWMKKTSSEFKITTNGWIIANTKRCPKCKTPIEKNNGCNHMSCKCGIQFCWLCLRDFSNCRDGVNCAYTYYHQGWANNEISRKKSGTNFGNFMVKDALKHIVECRRILRWSYVYGYYLPEDENAKIEFFDHIQSIAQVVLDRLHHFAENGLRKQLLHNGSEEEFCDFRTKLTTRARVAKSYFMNLVKELDNGLEVVCVKNYAVMAFSWQLLLRRLPTRRNLVNLGMGVELSCMWSVVPNLRSLLVVGLLPTQNHVLNHMTCKCGFQFCWLCLHSPCICNGSNRLQQVQEFQEIFGNEKKGSSTYLNFKDAWKQVIECRRVMRWSYVYEYYLPEDENAKIEFFDHIQLGFKY
The following text describes a protein:
Function:
Transcription factor that regulates copper acquisition and homeostasis, and which plays a central role in fungal pathogenesis during neurologic infection. The transcriptional regulation exerted by CUF1 is intrinsically complex since it acts as a dual sensor of copper levels, responsible for expression of a set of copper-specific copper transporters, CTR1 and CTR4, at low copper concentrations, and 2 metallothioneins, CMT1 and CMT2, at high copper concentrations. Positively regulates the expression of the copper acquisition factor BIM1 under copper-limiting conditions. Also positively regulates the expression of super oxide dismutase SOD2 isoform 2 during oxidative stress and copper-limiting conditions. Negatively regulates the expression of super oxide dismutase SOD1 during copper-limiting conditions. Also regulates ATM1, an ABC transporter with functions in the iron-sulfur clusters (ISC) export machinery, during copper stress. Another target of CUF1 is the gene encoding the laccase LAC1. Binds promoters of target genes at Cu-responsive elements (CuREs) that contain a variable A/T rich 5' region followed by the core consensus sequence 5'-G(G/C)CTC(A/G)-3'. Negatively regulates capsule biosynthesis, probably via modulating iron acquisition through the high-affinity iron uptake pathway.
Subcellular Localization:
Nucleus. Cytoplasm, cell cortex. Note=Upon copper depletion, localizes exclusively to the nucleus as an activator for CTR4 transcription, while it is located to the cell periphery in the presence of exogenous copper.
Domain:
The CRM-I motif (C-X-C-X3-C-X-C-X2-C-X2-H) and CRM-II motif (C-C-X3-C-X-C-X4-C-X-C-X3-C-C-X-C-C-X2-C-X-C) correspond to cystein-rich copper-binding domains.
Sequence:
MVLINDKKFACEKCIKGHRVSACTHTDRPLFEVKKKGRPSTQCRHCKEKRKSAGSSVHTKCQCGATDPKTLKDILASVNAAHAAANESGGASATANTSAEPEIETRKGQPGSKPTFPRGLKDVHEIAAAANALQGWGEDDQVVKAAERTVQALLNPCKCELGGPCTCCQIKTKPRRKHSGHEFENPASAGATPPGGGCCGSSVHSRDDVATRNSPTSINSSEAIHHPPQTAPMLHKTRLFSPYSTDLRRRDSSSSTGSKTPGWASPRAMRPPVSRIKPLTDMRRLMNAAVNQDGTLASEIPRSVVGLPTLPGIESFNTSANLENGEKSKDVDMPLAFPTSEDVVIGACMCGDDCSCPGCATHDHHNISPSNRTHDGSCGESCKGHNDCAHSIPIPSGVQSIAQLICIAASQVPPPPPNRTDSLNPHDTRILPPSVSLSEDVARTMGIVPLKPLECCGGKCGCPPGECACTKQCCGCCGECTCEKDEDTRMEEEGEYTESARDVTTSSCGGCKGKEKQSGFSDMMSPQIPQSVSPTSYHVPPLQPKPLNLPVSTIHHSTLSPSFNTPQPSPPAVSSPADSLSMAVHPSNGPNVRPVPMIQPRPILPKRASDTGLVMPQGSRPPSALGRSGSMTATKRSGTSTGVRRSNSDVRKVVGPSQPHHRPSIQSSSDRSFYIGSPSNQIAPGGVPMASAPSQMTAPLNSADSNSDLLAFIQQQWSADKTSNSNSDMNPSHPTMPVSLTAEPWAFPPQNETTDDSAPVPFDLDAFLMSIGVQPDGELRNDRPLSSQPPQSLMPNIPPTQPIAPLPPIPPSMSDVRPGYDMTFANFFLNSTPSGPSGPSAIPATNIPSRHTTPQASRPLTPPESSFTEPPRWKFPGDLGGEIPIWNGPEALEGFGVLGSPVSEKEEVTEESQNEKDIIDLSKPLDSAALTKIMKALEKQGGGQSSSQGAPSVANTDQQLQSLPALQTVPPVHPASVISPTRADPAHELDDMFSQFVTLDGTPIGSNNDGLGLNGGPGMMALPTNLSLGDELGFGGEMRWDQARMWSN
The following text describes a protein:
Function:
Localized to zymogen granules, where it functions in trypsinogen activation. May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity).
Subcellular Localization:
Zymogen granule membrane; Single-pass type I membrane protein.
Sequence:
MEVTGRLFIWAILAVSCGAQLNSTEAEGKSRCTASLGGANLGETHKALVLQLSANENCTWTIERPENRSIRIIFSYIKLDPGSRCETENIKVFDGSSTSGPLLGKACSRNDFVPVFESSSNSMTFQIVTGLTKFPRSVFIFYYFFSAATVIPNCGGDLRALEGSFSSPNYPKPHPELAYCVWHIQVGKGYKIQLKFTDLLLEMDENCKFDFIAVYDGPSTTAGLLKQLCGRGKPTLESSSDAMTVVLSTDYANSYKGFSASYTSIYIHDVNTTSLSCVSDKMRVIISKSYLPALNYNESNLQLNDPTCRPNVSNVIEFSIPLHECGTVKKIEDHAISYTNRITFIESPVSAVITRQKLLQIVVTCEMEYNSTVEIMYITEDDIIQNQSVLGKYNTSLALYESDSFENLVQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDFASPTYDLISSGCCQDETCKVYPLFGHYGRFQFNAFKFLKHLNSVYLKCKILICDNNDQTSRCNQGCVPRRKRDIPSYKWKTDSVIGPIRLKRDRSASRDSGLLPQIHEAEISNQPLSRLYLFSFMVLALNVVIVAITTVKHFLNRWMDHRYQKLQVY
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVKHKHYRPPGKKKEGNAARYITRSQAVKQLQVSLPLFRKLCILKGVFPREPKKKVKGNHHTYYHLKDVSFIQHEPLLERLREIRAYERKVKKADAKKNRDRANLLRQRRPTYRLDKIILQRYPNFIDALRDLDDCLTMVHLFAALPAIEERIEVKRIHNCRRLSHEWQAYISRTHKLRKVFVSVKGIYYQAEVKGQKVTWLTPHPLQQVLTEDIDFNIVLNFLEFYEALLAFVNCHLYRSINVKYPPILDPRLEALAADLYALSRYFDANSRSAVLDPQASSLSGSGNVESQQIGDSVSESELRLAQLQHQLPSNEPGALMHLVKDVAGEEEEDDDTRECKKLFKDMKFFLNREVYRESLLFVIPAFGGTVSWEGDGAPFEENDESITHQIVDRPMHGRQTLAREYIQPQWVYDCINARIILPTGGYLAGRDPPPHLSPFVDNEAEGYVPDYAETIKQWKTAGRSEVLPLPGVGKEDLEDPQKLLAEGVIDRAKAKEAVEKKKKMMALERQYHDELNKELHGVPHSSSVSNIDNHISGKETEDKEEFDDDSELAKLSLSRRKRGNLEAAEKGIKRKKDHIDVIRERKRKLKESQKSKEG
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MSTSSVPSLTYFQGRGLGQFSRVLLSYLGIPYENITVTEISDALRATLPYGQLPIYRDGDFVLTQSSTIARYIAKKHNFMGKNLEEEFLVDQIVTAIHADIFPAFNNPVPEKLQKLYEKYFGSFEKKLQETGFLVGSSVTLADLYVYVGFDYIRFRGEAALSSELSDEKYPKIAELKKFFESNEGVAKYIKERPETKF
The following text describes a protein:
Function:
Multifunctional regulator of the expression of viral genes that contributes to the shutoff of host protein synthesis and mediates nuclear export of viral intronless mRNAs. Also stimulates translation of viral transcripts. Independently, plays a role in the regulation of virion release. Also plays a role in the inhibition of host innate immune response by targeting host IRF3 and thereby preventing production of beta-interferon. Silences the 3' splice site of the host promyelocytic leukemia (PML) intron 7a, thereby switching PML isoforms from PML-II to PML-V. This could be linked to the accelerated mRNA export induced by ICP27 which might not provide sufficient time for PML pre-mRNA to be spliced in the nucleus. Also suppresses splicing of the viral ICP34.5 mRNA, allowing the virus to express a variant form of ICP34.5.
Subcellular Localization:
Host cytoplasm. Host nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Domain:
Binds viral intronless RNAs through the RGG region; The N-terminal domain is mainly responsible for the inhibition of IFN-beta induction.
Sequence:
MATDIDMLIDLGLDLSDSELEEDALERDEEGRRDDPESDSSGECSSSDEDMEDPCGDGGAEAIDAAIPKGPPARPEDAGTPEASTPRPAARRGADDPPPATTGVWSRLGTRRSASPREPHGGKVARIQPPSTKAPHPRGGRRGRRRGRGRYGPGGADSTPKPRRRVSRNAHNQGGRHPASARTDGPGATHGEARRGGEQLDVSGGPRPRGTRQAPPPLMALSLTPPHADGRAPVPERKAPSADTIDPAVRAVLRSISERAAVERISESFGRSALVMQDPFGGMPFPAANSPWAPVLATQAGGFDAETRRVSWETLVAHGPSLYRTFAANPRAASTAKAMRDCVLRQENLIEALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLENLATRLRPFLQCYLKARGLCGLDDLCSRRRLSDIKDIASFVLVILARLANRVERGVSEIDYTTVGVGAGETMHFYIPGACMAGLIEILDTHRQECSSRVCELTASHTIAPLYVHGKYFYCNSLF
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Sequence:
MLLMLFELSLFLQPARNNYQILSISLPDTLRGRFVTYGARATPTTVGSRPLAPADGPDRSRVHLALDYLASLRVPHSYFTHFYVASVLSSLFWAFQLLSRGSAFQAIATRISPQHLEKSMSIHQVLLCWALMLIQGIRRLHESRLFFKPSSSRMWFVHWLLGLAFYLTATVAIWIEGTETLMTHELTLDDVQVATAPTLRTFLCLPLFLIASGIQHDCHHYLFSLKKYTLPTHPMFQRIVCPHYTAECVIYLSLALLAAPNGEMVNKTLLSCFAFVTVNLGVTATISKRWYEQKFGPESVKERWNMIPGLF
The following text describes a protein:
Function:
DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair. Can also process hydroxymethyluracil (mispaired with guanine or adenine), hypoxanthine and fluorouracil. Exhibits a clear preference for double-stranded DNA substrates, but can also process uracil in single-stranded DNA, with lower efficiency.
Sequence:
MDLARVHTPRGWYDDFVNRLVNCARCPRLVSYRSTVKPLRRYESWSYWGRPVPPWGDLNARVMVVGLAPAAHGGNRTGRMFTGDASAQNLFKALFLLGLSNKPYSVSRDDGVEVRCVYITSAVKCAPPKNRPTAEEVYNCSSWLREELEAVRPRAVVALGELAWRAVLKILGATTAAFKHGEVVNAAGVRVYASYHPSPLNVNTGRLTVETLAEVLRRAAADAGCL
The following text describes a protein:
Function:
Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTGRSRVLAMRHVGGVSPVLVRRDLFLTRTLCSHGPSQPREKRPEEVALGLYHRLTALGAALGHSIRQRASSTAKTWWDRYEEFVGLNEVREAQGNVTEAEKVFMVARGLVREAREDLESQQTKLKEVRDRLDRISRDDNQYLELATLEHRMLQEEKRLRMTYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPVSLQEAIREQASSYSLQQRDLRDLVADLKGLVQAGTGQGSLSQAGSSPTQDRDTDVLSAALREQLSHSRQVRSRLEGLREQLDGLEKTVSQVAGVVQLAKAAAHPGLESADGALPGSLLEQGSMIMALSDTEQRLEAQVNRNTVYGTLVTCATFVAVLPVLYMLFRAS
The following text describes a protein:
Function:
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (By similarity).
Miscellaneous:
MISCELLANEOUS: In contrast to human protein, not inhibited by necrosulfonamide, because a Trp residue is present instead of a Cys in position 85; MISCELLANEOUS: Interaction with RIPK3 is species specific: mouse MLKL only interacts with mouse RIPK3 and not human RIPK3.
Subcellular Localization:
Cytoplasm. Cell membrane. Nucleus. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (By similarity). Localizes to the nucleus in response to orthomyxoviruses infection.
Domain:
The coiled coil region 2 is responsible for homotrimerization; The protein kinase domain is catalytically inactive but contains an unusual pseudoactive site with an interaction between Lys-219 and Gln-343 residues. Upon phosphorylation by RIPK3, undergoes an active conformation.
Sequence:
MDKLGQIIKLGQLIYEQCEKMKYCRKQCQRLGNRVHGLLQPLQRLQAQGKKNLPDDITAALGRFDEVLKEANQQIEKFSKKSHIWKFVSVGNDKILFHEVNEKLRDVWEELLLLLQVYHWNTVSDVSQPASWQQEDRQDAEEDGNENMKVILMQLQISVEEINKTLKQCSLKPTQEIPQDLQIKEIPKEHLGPPWTKLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGRSLSGRERILERLSAVEESTDKKV
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MFSTPNTAPCSLQASRNNTRRNTRQKMTLSCLLLAALAIMLPLSAEKAAAAAGDSLKAAAWQPVCQLAEALNKVPSNSKLRLRALITTTQGQRLAAAKLGVYALLAEEAQESKAAVVLAAWYSRLADLNDNLLKTTLVDTTIDAVASSIYVKGRADEALNILAQAKTTSNGCLLTDDSGTLAAHGPAKIGETPCSRKLEPPVLDTYENLDEVMDANGWKSSHATTAKADLAGSGGDKTCKLLTVDGAGFGAAKLDADLELGGGLWVVNKDDKQIKTVEIKKGSSTATKTGNMYQHAWHKLQALDSAEQETKPNATEGAEATSELQAAITNTLHNGQEGAAGQPETAVLAVFPKPTGTSINNLLHRANEAQLPEKIAGVNAKTKLRSIVDTHKFQQIEGALILQLKNENTKLKTSKSDEQKDDESTKNQIHCNSIAEVEKCNADPKCSYETKTDGTKKCKFNSTKAKEKGIPVTQTQTGGTTGDGVKCSDHKDQSTCEKANEGKTTKVCGWRSGKDNEDEKDKVKCRDSSFLLSKQFTLSVVSAAFVALLF
The following text describes a protein:
Function:
NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro.
Subcellular Localization:
Nucleus. Chromosome, telomere. Note=Co-localizes with telomeres and minichromosomes.
Sequence:
MTEPKLATTHVVGEPTFEGLARFIERNNITKIFVMVGAGISVAAGIPDFRSPHTGLYAKLSRYNLNSPEDAFSLPLLRQQPSVFYNILMDMDLWPGKYCPTTVHHFISLLAKKGMLLCCCTQNIDGLERACGIPESLLVEAHGSFSSASCVDCHAKYDINMARAETRAGKVPHCNQCGGIVKPDVVFFGENLPEAFFNVAGLIEETELLLILGTSLQVHPFADLALMVPSDVPRVLFNLERVGGRMFRFPTDRTPNFRASSYRLSTGNGNGSKISSGDSSNSSSVDGYDQFTLAENDETGVLRDIFFPGDCQVSVRSFAQALGFGEQLDASVREGREIFERTRRREKVVEG
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MSHGPRSGLTAVSSALLAMSRHLEVRDVLKTIVASARELLDAQYAALGVPDDHGGFAQFVVDGVSDEQWKAIGPLPRQHGILAAMLHEATPERLADVRKDPRFGGWPSAHPDLVDFLGLPIRDGDEVLGALFLANKLRPAGGDPPHPPCPKPAGGCGFTADDEELLGILAQHAAIALTNARLYERSRELTIAEERSRLAHELHDAVSQKLFSLRLTAQAATALVDRDPARAKDELHQVATLAAEAADELRAAVVELRPAALEEDGLVATLRTQIQVLDRAHAARVTFTGHGVKALPAAQEEAMLRVAQEALHNALRHSGAERVTVTLHRRGTATVLRIADNGGGFDPRTVRRAGRHLGLVSMRDRANGTGGRLTVRSAPGEGTTIEMEVPGG
The following text describes a protein:
Function:
A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.
Sequence:
MQIGYVRVSTNDQNTDLQRNALNCAGCELIFEDKISGTKSERPGLKKLLRTLSEGDTLVVWKLDRLGRSMRHLVVLVEELRERGINFRSLTDSIDTSTSMGRFFFHIMGALAEMERELIVERTRAGLAAARAQGRVGGRRPKLTPEQWEQAGRLLAAGETRHRVGLLFDVSISTLYKKFPVNQSR
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPRKTKARSRLDKYYNLAKDQGYRSRAAFKLFQLNRKYNFLNNARTVVDLCAAPGGWMQVCAQIMPTSSIIIGLDLVHIKPIPGCKAFTQDITTPQCVQLLKKEIPQKADVFLHDGAPNVGASWAKDAYNQNDLVLSALRLASQFLKKGGVFVTKVFRSTDYNSLMWVFNKFFSKVEATKPLASRFVSAEIFVVCLDYLAPEYIDEKLFDSKHVFKDTETDMLQQQIQKEIVSRTQRHRSGYADDVHQTVYQMIDFEEFLHAENPYPIFIEYAGIKMTEEAKQKYLGLAKPPQDYEILMEDIKVLGKREIIQLLKWRSKIKHFLSKQKKEQKQLEKQEQQESAEYEDLDEAEGEGQDDEVNEEEAEEQDDLDKLVDKQKEALEQQYIEEQKKELKEQRKQKQKQAQQEKKLSGRGIGFTPQEEDQELFQFSKHKNILKLGYVDVEDKQEEKLKKEKLEFNNQKQLDKNLELIYENKKQKKENALERIRNKKQALESEQEEVDADELACKPIKRVKKQEDHLKVSDLKSKFFDKEGFQKLKEQLKTQKEDVFDNPLKNQNITQLDKKKKEKTDKEQAADKFKNDSDSDELEEKVMDPKQLKNLQKQIQDDLNQLDDNKDVDLLRRVDKKEMEYQKKLNAKITQDPLPGEDEKVKQFELNLPISDMEKRRRQLKKIAAREEKKAKQASDKDPNHKELEIVPEKRIEDYDIDQLASNLALAKKMMRKKTREQIIENSFGRDKWEDQDLPQWFVDDEERHVFKMEPITKEEFQQEKQRLYEINSRVPKKIMEAKIRKWKKAQKKLKTAAKKAQTVFDTDGINQKTKMQQVRRIYNKEKANIQKEQERKVIVARKGQASGKFKSSRKVLTVDKRLKKDKRAMKAKARVGKGKKRRQVSRRKGKKQKS
The following text describes a protein:
Function:
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is lethal to insects (A.domestica). It is not toxic to mice and does not affect mammal F11 sodium channels.
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
MKILIFIIASFMLIGVECKEGYPMGRDGCKISCVINNNFCKVECQAKWRQSDGYCYFWGLSCYCTNLPEDAQVWDSSTNKCGG