lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence'. Acts as a negative regulator of apoptosis. May play a role in hepatic lipid metabolism.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTCLGLSRPSKRVADEAGNFSPLGQACGCRALRFLKGKVSVLLATALPANVAFLCCRGSQAKPRRRSRSGWRSEQPWMPFVPKWTLPTGLNVSIECKRVSGLEPATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSVPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSMSGCCGEDCSYEILSRRTKFGDSQHSHADHGFLIPLTQGDQKEPPVFIPCKVSSVYIVSFQSLDAWHQLVKGCLVPYPAHPSLCRPCPEGFLRRSGLGWERHCLRPAVTLVGVEPIHFQNICLSPLPPGLGFEKHSRHGWAGWLTPVISALWEAEAGRVT
The following text describes a protein:
Function:
Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction. Preferentially modifies the beta-tubulin tail over an alpha-tail. Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, dendrite. Perikaryon. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon.
Domain:
The enzyme uses its core to engage the disordered anionic tails of alpha- and beta-tubulin and the flexible c-MTBD (cationic microtubule binding domain) region to bind the microtubule and position itself for beta-tail modification. The c-MTBD region is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on alpha-tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
Sequence:
MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRRSVSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHLPHSNDACSTNSQVSESLRQLKTKEQEDDLTSQTLFVLKDMKIRFPGKSDAESELLIEDIIDNWKYHKTKVASYWLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRVFNRLLWSRGQGLWNCFCDSGSSWESIFNKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYATDKRGSLSGIGPDWGNSRYLLPGSTQFFLRTPTYNLKYNSPGMTRSNVLFTSRYGHL
The following text describes a protein:
Function:
May phosphorylate a specific serine in the N-terminus of a myosin light chain.
Sequence:
MPSNPNRSIYDFYNITDIIGEGTFSTVTLANHIEKIEDKYAIKIISKEVLDNERRTYVDWEISILSKCQHPNIIKFYEHYESDEDICLVLEWIPNGDLFDRIVKKGVFNEEEARLTMKSLLSAVEYLHDKSVVHRDIKPENILFSDSYGGIKLGDFGLAKFYEESIGLELACGTLAYSAPEITNNQVYRKSVDMWSCGCILYFILFGRPPFYSDDESEMFELITKGQWEFPSKTQHKYSDQVKDLIKLLLENDPNKRLTVKQSLAHKWIQSIDERSFSSVIKQSPLITSQQQQQQSPSSLLSSSSSSTASSPSLKPLSPLVAIIEQQEYNYNHQQLQNHNILHSSNSHSRHHHASSANSTTVDQQQEEDNNHHYHRHNSNNNINNNNDNNDNNNSNSNNSNNNINNFINNNNNNNNNNSNFFDDDDEIDINQNEMDDIDDEQQQPTNSLRSSSKPIAIKKSQIRTSLNGNIDIKRGVLTPL
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MGKAEESGRKETQQSISMQVMNLPRDLLQRFMSSSNHFSQNGETEEEEQEEEIELSLGLSLNGRFGVDPKAKKLTRSSSIPDFINNTNESSSSPSYLFPMACGSLVRTCSLPVETEEEWRKRKEIQSLRRLAAKRKRSEKQKNLKALKDKNREGLGEENCDEDKKEEGWVNGGRGPLMAASQGSIGSQGSGSSGISELDSQPPQGTYKCQGSRSPTSVQSTTQTEQKPNIINPGKISTQKSEKLAGITAKNQHNQPGVDEKRLRASLKNIMEDMPCVSTTGDGPNGKRIEGFLYRYRKGEEVRIVCVCHGSFLSPAEFVKHAGGGDVEHPLKHIVVSPSFIF
The following text describes a protein:
Function:
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Sequence:
MVEMLPTVVALVLAVSVVAKDNTTCDGPCGLRFRQNPQAGIRIVGGQTSSPGAWPWMVSLQIFTSHNSRRYHACGGSLLNSHWVLTAAHCFDNKKKVYDWRLVFGAHEIEYGRNKPVKEPQQERYVQKIVIHEKYNAVTEGNDIALLKVTPPVTCGDFVGPGCLPHFKSGPPRIPHTCYVTGWGYIKDNAPRPSPVLMEARVDLIDLDLCNSTQWYNGRVTSTNVCAGYPEGKIDTCQGDSGGPLMCRDSVDSPFVIVGITSWGVGCARAKRPGVYTATWDYLDWIASKIGPTALHLIQPATPHPPTTQQPVISFHPPSIHPPWYFQHLSPRPPHLRPPRPLLHQPSSVHTSSAPVIPLLSLLTPVQPVSFTLAAYHTRHHTTLSFARRLQHLIEALKMRTYPIKYPSRYSGPVNYQHRFSTFEPLSNKPSEPLLHS
The following text describes a protein:
Function:
May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity).
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=Found in the principal piece of sperm tail.
Sequence:
MQLYLVLLLISYLLTPIGASILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVYEDPQDGSTGFGLFQIRDNEWCGHGKNLCSVSCTALLNPNLKDTIQCAKKIVKGKHGMGAWPIWSKNCQLSDVLDRWLDGCDL
The following text describes a protein:
Function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MTKQAEETQKPIIFAPETYQYDKFTLNEKQLTDDPIDLFTKWFNEAKEDPRETLPEAITFSSAELPSGRVSSRILLFKELDHRGFTIYSNWGTSRKAHDIATNPNAAIVFFWKDLQRQVRVEGITEHVNRETSERYFKTRPRGSKIGAWASRQSDVIKNREELDELTQKNTERFKDAEDIPCPDYWGGLRIVPLEIEFWQGRPSRLHDRFVYRRKTENDPWKVVRLAP
The following text describes a protein:
Function:
Inclusion membrane protein probably involved in early modification events of the chlamydial inclusion.
Subcellular Localization:
Secreted. Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane; Multi-pass membrane protein. Note=Secreted, probably by a type III secretion system (Probable). Localized in the inclusion membrane. Inclusion membrane staining is punctate.
Sequence:
MECVKQLCRNHLRLDNLTDPVRSVLTKGTTAEKVQLAACCLGVVCSIICLALGIAAAAVGVSCGGFALGLGIIAILLGIVLFATSALDVLENHGLVGCPFKLPCKSSPANEPAVQFFKGKNGSADQVILVTQ
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MSGQGEDDSDISEEFSGEENEGWDEDISDEDDVIDEEEEEEEEETNQMEEAGRNIQQLAKRVLEDEETTDQPPTKSVRTGKPDLYRPPTNEEMNQLKETENLFQSSLFRMQIEELVSEVTPKNKKSPALDKVLHSLNEIVMKLPKTDSKELTDQSWLPSNVKVPIQQSPYQVKGHFHFAPPTSMKVVGSYLLGFCTKPGMNVDVLLEIPKECLQAKDYLNHRYHRKRALYLACLAASLDKQDLFTSVMFTFFHQDCNKPVILLKPSGKAGKHYTIRLHACPPEGFFKPSRFHPDKNNIRSDWYMGKGRDQDSEPPTPHYNSSILVDMTMAEHLHHLFSLSADFPAMREGLVLLKVWLHQRELDTGSGCFSGFLMSMLLSYLLSAHKLSKVMSSYQIMKNVLQYLANSDWSTQGISLASCVTAEDVPTLSDFHQAHQVVFVDPTGHLNMCADMSTATYARVCHEARQAVAILEDKSLDGFQLLFMQTVPFAHKFDHIFHITRVPRLRLVCEHMSLQDAVMDHCGNYLMAALPSILQLLNKALGNRVSLIGVRGHDFGQWSIGDAPPSLKDIGRLTFGLLLNTEFSTSVLDKGPPADQPQAAEFCEFWGDKSQLRRFQDGTICEAVVWQGSNIAERRLVCCQVIQHILNRHANIPQSIIKYFGGHLDSLLSRPNLQGGTAAQSTDTHDKLHKSQPQGKKAKKSKNAPKEQLLDPNQNSTSHPGTGDEENVTVMRVYNDLCRILRGLQDLPLNITSIQGTSPVFRYAEVFPPRPAHMKKTKDKTVVQGHIQVPVSGQPCPPFVPALKVICHMEGSGKWPEDADAIRRVKAAFHIKLGELLHKQHGLVTSAATGHVDIAMGGFVFQLVIAYHREVNILKLEKTAEGLLRERDNEASRHLERETVMLPKLTSALHGLQQLYSSFSGCLRLAKRWVSAQLLHRHVPDVMVDLLVAHVFLHPQPLTPPGSPAVGFLRFLHLLSTHDWKMNPLIVNFNRELKAADLQEISNQFTSCRSQLPIMFIATPNNKLTSHWTKAKPTVQVLQRLISLSQEALKMLEVQILTASDGTDFKQVFRPPLDIYDVIIHLNPWNVPRRSEGVDYLKLKGCRDVPTDGGMGQGSKEILPVVEFDPVQMYLEELEDTYGDMALFFHDPCGGLYITALWKPAAFTAKPFKVTTLNGRAPDLDQSGEDLMMIPNVAAILEDFHSLGKGLVILVDVKKERPVVR
The following text describes a protein:
Function:
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1) (By similarity). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
Subcellular Localization:
Nucleus. Note=Predominantly nuclear.
Sequence:
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISNIDLNSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFRVVDMVDVTEDFLAKAKTYLGEEGKRVRNYFCCGLQDFSPEPGSYDVIWIQWVIGHLTDQHLAEFLRRCKRGLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLEVVRRIIRTAGLSLLAEERQENLPDEIYHVYSFALR
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MSVKSAAMRDAADSEEFEDMSEDYEEASDASYEYEEGSDDDACHMDAAHGDAGPSSSAGPGWSVLNQDAIVKLQAEAVADVVAILGVKSSVAKTVLMYFRWDKEALMSKVAERDPESVLKQAGVAITDAGSAGPNGQQGGPIMCRVCFTDTEQAETTSMDCGHAFCNDCWRQHFKTQIGEGQARTIRCMAPKCGVVCDEEKVCSLLKSDPAASSSTAAGSGSAGPSGSAGASGSAGTSGSGREPNEALDKYKHSMALSYVEDNARVNFCPSVPWCGHAVQVDGDPFVEPECSCGKVFCFKCLKDPHTPCTCKMWDEWDEKIHGDSETRNWFMANTKPCPKCSKPVEKNGGCNLVMCKCGQAFCWLCGAATGTQHTWQKIEGHSCGRWKDELDRKIDNAARSHKRYMHYFERYKLHMDSYSKEGVKRSDLLKRIGEMVETGIEARDYTWLVRALDQLKVARGVLSNSYAFAYFFFGGEMYKDDFSDEDNKRNQDLFEEHQQRLEGEVERLSGLVEECSESLTIDSDARVRVINSTVSIESRILKFFDMIEVDLYGKLQSCSAQIAVYRPKRNLVA
The following text describes a protein:
Function:
Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MEELSWTNVHSQDIQIEAESFWRAIDIWWLKPQVINRRISASVEQHKISGLSESTAAGSLAELSRVTPAVRLHEQWLFSLLNDLKHLTSQEENTTSISFEKCIDHHVSLLEESKNETMSNNQVSKCESGSVGEEKVTEQVAEIVTDNHTGEMENEESLLLDKSKMCVICIRKLLPRRASDAVVHEVGIFDHERNEATFTLLECGSKEAKFPSYKFSFQCSRISLHVDDNYKSAPYSSSIPSIEWLGNTLAPKLTKWASEIVGSGQVVVVKPLVPMDRYTELYREMKQKYGTEFVKIWPENTDPQKFVYEDVAIATYLILLFEEERKETGDDKKQSYVDLGCGNGLLVHILNSEGYPGKGIDLRRRKIWSLYGPETHLEESTIIASMETSFKDTDWLIGNHSDELTPWIPVMAARSSYKTRYFVLPCCFHDFDSKFGQRVGGETQYRTYLNFVREAGEMCGFEVEEDKMRIPSTKKICHVGRRKTYAAEEHPQVLARMEEYVACRCRKSACHKRKSHLIDSVRDSESSRICPVSSLETGIGADSAESTACDCKDTECTHKRELTSSDSSSTEGQCLGGEGDTDKNLAPNFKPRAVEERVKNCSRVERSLKDRITLEVAWAILEDGGVRRTSKDGDEVQGGGGVQDDTGRSSKMPKLWRRGGSIGLGDAAKLFDGPTLKNLKSECGGLKTLLKNYNPVFEIIKSKVSLKDWSQLPSSDATDPVSSSGSSSRTASRQSEKKDRERQQLYKTKLCWFHEHHPDSCPRMAEACPFAHGQVELRSRPTFGKAPVI
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MHCRAHTVSAMPPSSPLVKLPLLPRGLLSYLPASILPSSGRESTITPTTSSPSTPPQPAPPSPKKMSSSPGQQQQAGSGGGKADSAELARVFELFDKNGDGRITREELEESLGKLGMSVPGDELASMIARIDANGDGCVDVEEFGELYRAIMAGDGGRAGGEGAGAGEEGAGGEDADEDMREAFRVFDANGDGYITVDELGAVLSSLGLKQGRTAEECRRMIGRVDRDGDGRVDFHEFRQMMRAGGLATLG
The following text describes a protein:
Function:
Component of the volatile terpenes biosynthesis pathways. Mediates the synthesis of a blend of monoterpenes. Converts mainly geranyl diphosphate to alpha-terpineol. Also triggers the biosynthesis of minor monoterpenes including limonene, gamma-terpinene, beta-myrcene, terpinolene and 4-terpineol.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MAGITGVMNMKLAARPSSGRHSRGCRPAVVPSAGKQMLLVRRHPPGSASWPTRATGGGGGGVPAGATAADSSGQAKEEEEEDRASRNTSSFEPSIWGDFFLTYSSPLATSSAQKARMVHRAEQLKKQVAKLIAASGACSLYHRIHLVDALERLCLDYLFEDEINDMVTQIHNVDVSGCDLQTVAMWFYLLRNHGYRVSSDVVFAKFRDEQGGFAANNPRDLLNLYNAACLRTHGETILDEAASFTSKCLKSLAPYTYMEASLASEIKRALEIPLPRSVRIYGAKSRIAEYGNQTEANELVLELAKLNYNLVQLQHQEELKIITRWWNDLELQTRLSFARDRVVECYFWMVGVYFEPSYSRARVILSKVLAIVSLLDDTYDVYGTSQECELFTKCIESWDPAATGGRLPGNMKFIFAKILDTCQSFEDELAPDEKYRMHYLKTFIIDLVRAYNEEVKWREQGYVPATVEEHLQVSARSGGCHLLSCTSFVGMGDVADQEAFEWVRGVPKIVKALCIILRLSDDLKSYEREKMSSHVASTMESCMKEHQVPLEVARVKIQETIDETWKDFNEEWLNLNTNSHLPRELLERIFNLTRTMVYIYQQDDAYTNCHVIKDTINSLFVEPVSIT
The following text describes a protein:
Function:
Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium. Required for primary cilium formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centriolar satellites. Also localizes to the distal ends of the mother and daughter centrioles (By similarity).
Sequence:
MKSRKVKSVRPGRGRILGLTDVTPSTSLPPLVEGQVRSFLQVTVSKILWTVPKPPPSVLVRLRWWGETANGTVFRPRDSSQTEQKGAKTTTRYAVRCGPKQFTSYLTDMGMLVFEVMTKLDHFPIGRAQISGIAQLSLAHPVSGFFTIVSPTSEKLGELQVSVQLEPLPETYDSSSSAPNTDISFDHASESYGKALTGHPTTMNDPPQPIILSLASADKRESESSSRVTTPRGRDHLYFQENADPGKDSYRGTQDHVTVGWSNVTEGVQSIKPIYSEGTTAGKDALTVNSGPATKDLLSALLDQGSKLRDAMVVSALKSSPDLDHNPDIKLPLALNNYSLSQARATSEIPSPTLMRNLLNSRHSPQTRDILLQPADSFIPDMEAPSDAKAIELLLGSSVLSPGHYWDGTGSPPESISGSDFYNESELNDPLYDQSLLEKLFYKAPKSDSSASDFMSDDENTRSQNKKNKIALDRGRHRDNSPSEYKEDAKQTKGNDSLRDSKTSEKSTSRCEGISLSMDQAALLGQIHVAHVVVESLRVPLDGTAVTPSKTNSRGRPPRPVRPAKQTFFVEFQFPVLSKSRSGEVNSATEITRLVSSKVVNGSIKFQQRFTFPVLFSGQMIKHWWNTDLTFRIFLRKGTQNKPGPVGSATLPLRDVLQSPGLSVTCSLPVSCTAEDSHTAAGPLKISVALAGDNKNIHDISEKTLEPENQAPVLPAVTSKAELENSASYTDLRPVAEKSSPLRQSLPPHIGNGGPKVSFSQNPQQTAEEDGLLLHIVLMVPEGKGLVAAGGDSSGICNSYLNCKLFSAQEATRSSVVWGSTQPQYNFSQVAPLTLNARLLERMKNNVMIIEIWNRVASPGQDQLLGLAKLPLHQFYMSFSDPKITRLLLQAQYPVVAVDSYVPIIDVFSGCDRGKLKVLLAIGSGDQVVALQRLKNEEGTSQTAMPRPAHFLDPPLSSSQMGRPQEGMTDHIFEIHVENVKGLTPLQSTVWGEADCFVQYYFPAHGPDSHTAIDLPEIAMTLKPVRTATTLCVPDPVFNDRQSHTIVAQSDTPVQRLLLGAYSMQGLSGGGGVPFEIWCRYYYPNVRDQMVAKGVLPLSRLCAMVTMQHREDVGIQAFSLPLIPRSEKSAELPPQPSGLLNVNVTYRRSMRNPVGMLATRMASISVQIHRASGLQAAARLVAQQDASFQYSADVGVNAYVTIHPAFLPDVELRNTRTVARTFCPEFDHHYEFPCNMVIQRNNGEACSLAEVLYFSEIVLSIHHQNVASVGSTRPQPVRDYHLGMVRIPCRQLITKRSGVSGWYPVTVPEDSKLPTDSTILHSVVGGLELSVHFAHHSDRDRVLEVARGLGWNEYNEDFQEAIATEADEWHKREDLVNLSVNIPKIWLPLHCLLLAGHKHIHKSTYCYLRYKFYDREAVCSPLRRPRLSEDGQQATIMFELSENRELIKHQPLVWYLREERMEIQVWRSYGKDTNGPRPQDTDRLIGCAYVDLKALSENTSRTLAVSGVYPLFKRNVSSLWGAAVRVHLALSSAYHPSNSSRRLSCAGERSQSEGEEWAPTSGDSFEEKQDDSAKNDKPEAKTEVPLLDAKEQPVGEVDLKNTFAASIVVERAMHLSLKGTPLTERAAATPTCCVSYPVAGCSEPVTTPVIANTDSPLWNFQHQARLHKELLLDPQQRLVFKVWHKTDVERVVGFASVDLSPLLSGFQSICGWYNIVDFVGQCQGQVKVSITPLEGVAHLKTKVTSQRSSSYQSRPAFCSSFSYNPSQSEVPAFIPHIPTLHHQLSDRENSGPLFPFLRHEEHMENVRRFHESLQQAERNAHTVEGLDSLSQSSRSSLLSALRKNLGELDEIQKYFNQKLYRSISNAETSRCASVQIPQVQPPNSEPAEEDSDAKMLLQKSSFLVSQVSNLITGLQGIPKFAPAFSSTEQRLDVQGQTSVQHQQVDNMEPMAPERSEAYEREGQRSDTPPFSPLGSLNVSGEKLMEFIGTDMDEKERHLFAEKHQEEQDKHIIHGSSDEEYEEDVIEPRTLNEITTMTDRTSPWSSILSERDSDSMDHPQDQPVNPLAAENNRVITDFFSSFHQNDPSSVLSSARSTDSEVLAEGSRVRKISSSSGSEAETVGVQLSVDPAEQGALGEAESEAESQEMDGDPEANRTEEEQQDPVTVFSALSSGSDESEHITYGASEPDCSPPQDEPETDYPCSEPLEGNMHHIDEEEQPAGSESPQVPPSNLLSDPVIVPNFFLPPQHLEASMRHLSLSAVREGRSDTPGIPFRRSKRQKPRLAPADLPKEETNRIARIFAAQFPGPPTPP
The following text describes a protein:
Function:
Component of the intraflagellar transport complex B (IFT-B) involved in flagellar assembly (Probable).
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to the cytoplasmic and membrane-bound portions of each of the eight axonemes, localizing particularly at the flagellar pores and at the distal flagellar tips. Localizes to the basal bodies.
Sequence:
MIAPRLSMPAIVNAQSLVAKLRQLNCEKNYCHPNNLPGFTASAFYKESSSPLDQLVQTARLCHWLLSQLGISVQGVSEFDDPIAISTDLLVACKDIVNVANIPPHRIRMGYGDDLTALVLGIADACLAKLQPNIVSWKSLGSENANAGVERDNDDDDAPILDDLIVDDALIGTMTAKKGTFTTAAGLATGSLTTDSGCIAPGLISEADWEQELMAVDSQLGGKQLGGVYAGQDWRKDVVSMSLLAKALSKETGSCAQSISGLVTDFGKQLERISTREQHLNSQVGQYSAKLGDANRTHAGVTEELAELSQSISALTGELSTINEKLRALKVELQVESARASDTSNIHIVKTAFSSLSGEIRQLDLRITLAQQRLFSIAPPEPNTVRI
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MASIKYNIPKDGKLGFRLAESEPKFNWRNNPRIADCRRLVTNSIQVHLVQNASMNFAPEIPALAAYLENQLFKDALSENDYMDREKLLIRVQNLINLRWTSAQHEPMHATTSLPTYVSAPTLGMKSNLINKPLCDQYTIADTGCMLDRAPKLLADVPRSSIYGSQKCMLEANLWQPELVPPNNHFSGMGFSNAESGDSGITYSGLQYDSEASFESHRYKYQDSTKGEANFDIFNDMNSPSVHTSAMARENLKFEVSSVSDGLYMRQPVLGSLQLKQQLSCLESHSDGRFGENESLGSLPVQNRNLYALPGTTSTSSNTQQLPAVLLVNYIIYNLSRGRLKVPLLEFLHSRNCEGGICKCEEHKWFLSHYDDCGSANCNICGPAVKECSARGINIVQPGLRKQRIGVDRLTHSNDCGKRVCVNTSEDLMNPAKSRKLDSSPRSDSPCDVSVLTEEPFSPSGPLNFAQPSVSQMMATIANPGANVEITTSHTNDALRISEVDNSHLDDVLGSGDATLPSEGVSAVVQQKDERVSSHIYDAARLSQEGNGTLKDTWRSNSDDVTKFSDDPSADDFCQKKIEPAVNELKVEVPDSRCELPSDYVPTFCDDKSIAPNVDFTPGRDPEEIQPRINQEGFPPIPGSWTGMKSEKQKVDGISLIDFFTPEEIKQHISGLRQKDDQGIIKELVGNGASCSVSENFCQLCALPQLAFSPMPLYCSSCAGRIKKNATYYSTNDKTCDPFFFCTTCYNKCHREFTFYGLSFSKPNLETLKNDSLTVESWVQCDRCEGWQHQICALFNDKKDLGGKSEYLCPRCYLEDLEFGVHMSLPRSSSLDASNLPQTLLSDHLEQRLFESLKEERKNRAKAAGKNPEEVPHPADLAVRVVSSVNKRVKVKQQFLDIFPEKSYPAEFPYRSKVILLFQRIEGVDVCLFAMYVQEFGSSCSQPNQRCVYISYLDSVKYFRPDTKTVKGEALRTFVYHEILVGYLDYCKKRGFVTCYIWACPPVKGEDYILYCHPETQKTPRPDKLRQWYQSMLKKATEEKIVVNFSNLYEKFIAPTEEYNTKVTAARLPYFDGDYWSTVVEGMIKKIDKKSRGNPQEQLKGFTKRRLKAMGHTNPSADDAKDILLMQELEQSISSAKEDFIIVYLQFVCTHCHEIISGIRWFCNQCKNFQLCGRCHDVAKQSGPADTHMSSAGQRHALSQEVVNDVPVDTEDNDAIMDNCFLENRHALLSFCQGNHYQFDSLRRAKHSSMMILYHLHHPNGSNAGTSCGLCLKDIISADPRWMCEICPEFNVCSSCYEKRGAFCHNHTLMHHPSTAIRKTEVKMEELVKQLLDVLLHASRCQTTTNHPCSYPNCVILRRLFSHAHACSIRVAGGCRHCKKTWFILLMHSRKCKDSSCGIPRCMELKNHARRIELESASRCLPSVSVIN
The following text describes a protein:
Function:
Involved in ethylene- and salicylic acid-dependent cell death control associated with cells in the vicinity of vascular bundles.
Subcellular Localization:
Membrane; Single-pass membrane protein. Plastid, chloroplast.
Sequence:
MAMLSTASVSGSVDLPRGTMKVDSSASPEVVSDLPPSSPKGSPDRHDPSTSSPSPSRGGDNQSEVISKSEEYRQLFRLPADEILVQDFNCACQESILMQGHMYLFIHYICFYSNIFGYETKKIIPFAEISCVKRAKTAGIFPNAIEILAGGKKYFFASFLSRDEAFKLIHDGWLEYGSAVKSEGEILVTEPQVSDGVVKRARSSMDLANELDIPVRDETLHLSSSSSLPVISQNGVPPSSVQRHAEPDVDVVAANTFNWKPEDTDAPKLSSDFTKVAEAKFSIPVEEFFRLFFSDGAVSFVESFHKNCGDKEFRCTSWQPHEKLGHTRNVSFQHPIKIYFGAKFGGCQESQKFRMYRNSHLVIETSQEISDVPYADYFTVEGVWDLKRDCRDSVEGCILDVYVNVAFSKRTVWKGKIVQSTLEECREAYAHWIRMAHELLKQKKLENQEGNKLIEDGEPLAAREERVSECDEEGKVEMVGEGVVKKSLKEAWVNLTSFVKRQSGTRQVIVLAFAVILLMQVTIVVLLKKGGGGQVEYHERYDEYSVNGETLGWLEKRMHFLREEMMMVEDRLQRMRQDHAALKAQFHHLERLLRRNKQ
The following text describes a protein:
Function:
Acts as a transcription factor that regulates development of thoracic vertebrae.
Subcellular Localization:
Nucleus.
Sequence:
MTSRDQLVQQVLRDLQEAVESEGLEGLIGAALEAKQVLSSFTLPICQKGGPGAQVLEVDSVALSLYPEDAPRNMLPLVCKGEGSLLFEATSLLLWGHTGLSLELRARTVVEMLLHRHYYLQGMIDSKVMLQAVRYSLCSEESPEMTNLSFATLEAIFDADVKATCFPTSFSNVWHLYALASILECNIYSIYPMRNIKIRPYFNRVIMPRCSTHVTSMLHIMWAGQPLTSHLFRHQYFAPVVGLEEVEADCTASLNPVPPNLGPLLPPAKTLELLNREPGLSYSHLCDRISITKSTFYRWRRQTQEHRQKVATRFSAKHFLQDSFHRGGFVPLQQFLQRFPEISRSTYYAWKHELLGSGANSALGPATPSREALAVPEVERPPGKKAAEEVGCSSLAAAMLSPPSMILMQRAKSFLEYCISLNKLVPYRCFKCRFPGISRSTYYNWRRKALRRTPSFKLSQAAFETAESLQPTDVGKETPFSLKREAGEEETGKAGSGAPLTSRGLISPKMPLSRWQRRLRRAARKQVLNGHLPFCRFRLRYPSLLPSTFWVWKSLSRRSPGMQIPSLSQRRQKPQGRQKPEGRQKPEEQQKPEGRQKPEGRQKPVEPQAMEADQNVPAMVVPPAETLPVATSPEDVPGGPSREGNIIQEAAMTQSQPHSGSLPSQTLAEAPGGSDGQVLVMDMLTTTRFKAQAKLFLQKRFQSKTFPSYKEFQALFPLTARSTYYMWKRALYEGLTLIDG
The following text describes a protein:
Function:
Involved in the CpXpG methylation and in gene silencing.
Subcellular Localization:
Nucleus.
Sequence:
MAPSSPSPAAPTRVSGRKRAAKAEEIHQNKEEEEEVAAASSAKRSRKAASSGKKPKSPPKQAKPGRKKKGDAEMKEPVEDDVCAEEPDEEELAMGEEEAEEQAMQEEVVAVAAGSPGKKRVGRRNAAAAAGDHEPEFIGSPVAADEARSNWPKRYGRSTAAKKPDEEEELKARCHYRSAKVDNVVYCLGDDVYVKAGENEADYIGRITEFFEGTDQCHYFTCRWFFRAEDTVINSLVSISVDGHKHDPRRVFLSEEKNDNVLDCIISKVKIVHVDPNMDPKAKAQLIESCDLYYDMSYSVAYSTFANISSENGQSGSDTASGISSDDVDLETSSSMPTRTATLLDLYSGCGGMSTGLCLGAALSGLKLETRWAVDFNSFACQSLKYNHPQTEVRNEKADEFLALLKEWAVLCKKYVQDVDSNLASSEDQADEDSPLDKDEFVVEKLVGICYGGSDRENGIYFKVQWEGYGPEEDTWEPIDNLSDCPQKIREFVQEGHKRKILPLPGDVDVICGGPPCQGISGFNRYRNRDEPLKDEKNKQMVTFMDIVAYLKPKYVLMENVVDILKFADGYLGKYALSCLVAMKYQARLGMMVAGCYGLPQFRMRVFLWGALSSMVLPKYPLPTYDVVVRGGAPNAFSQCMVAYDETQKPSLKKALLLGDAISDLPKVQNHQPNDVMEYGGSPKTEFQRYIRLSRKDMLDWSFGEGAGPDEGKLLDHQPLRLNNDDYERVQQIPVKKGANFRDLKGVRVGANNIVEWDPEIERVKLSSGKPLVPDYAMSFIKGKSLKPFGRLWWDETVPTVVTRAEPHNQVIIHPTQARVLTIRENARLQGFPDYYRLFGPIKEKYIQVGNAVAVPVARALGYCLGQAYLGESEGSDPLYQLPPSFTSVGGRTAGQARASPVGTPAGEVVEQ
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MEGRPPKSPTRRRLPQSPTRGRALGSPSTCGRAPGSPSTCGGGRSPGSPSTRGMAGCRPPHRRAAGRRAPHRRVAAAGCRDPHRRAAGRPAGRLYCCSCDFFLTLNLAVWDLCRCSCFASVW
The following text describes a protein:
Function:
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGSRGDKSVTIQAPGEPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLDCSRHLGVAAGAILALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVISYWLFYGVRILDARERSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQYHKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKFVMRLQSETSV
The following text describes a protein:
Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence:
MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGSGCGGCSSSCGGCGSRCYVPVCCCKPVCSWVPACSCTSCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCKPCCCSSGCGSSCCQSSCCKPCCCQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI
The following text describes a protein:
Function:
May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion membrane.
Sequence:
MSVSLLQPYFFMSKTKSYAQILIGSRLFLTAMAIHLSLRVAPPDLQQGGNSRISYVHVPAARMSIVIYIATAINSSLFPLTKHPLFLRSSGTGTEIGAFSTLFTLVTGGFRGRPMWGTFRVWDARLTSVFILFLIYLGALRFQKLPVEPAPISIRAGPIDIPIIKSPVNWWNTSHQPGSISRSGTSIHVPMPIPILSNFANFPFSTRILFVLETRLPIPSFPESPLTEEIEAREGIPLKT
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MLLDEDPATLIRHTIGNFNIVPDKSAVARINESLSTLQQARDLRIREAESALKKLSRNLNTLNNNHLETVSAHSPTAHASEIATLDTQKFRIAKAASDLEIESERLSSQLADLQARLQELEQQGMEGGENVKRGQVDDEISLKLKVYRGLGIDIERDRESGEYSKAIIRNGKKGDVHVVNMDNKFSKFFYANYFWQTL