lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May regulate basal insulin secretion.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLRMRVPALLVLLFCFRGSAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGTTFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPSGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLHLPSVGPEDAGDYVCRAEPGLSGLGGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEEGTLETKDPTNGYYKVRGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPTFYDFNPHLGMVPPCRLYRARAGYLTTPHPRAFTSYIKPTSFGPPDLAPGTPPFPCAAFPTPSHPRLQTHV
The following text describes a protein:
Function:
Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells.
Sequence:
MRRRNLIITSDSDSDDGGGGGGAATASTPASASASASFPSVSGGGCGDGWPSPQNPRSVPVQFPSPSSPPPSPPIEISDEEEAEAEVVVEEEEVVVVEDEEEEYEEVEEIEDPDGDSPFVDAPEHISPPPPPPPPARTPMPTPTPTPTPTPTRPPVPVWAAPLPARTPTPTPSAPPRAAAPSPAGTPSPSPIPPSSTPVSALSGPLRQVDEFLRGLGLRLRPEWLESCAAGVPGFYGLGGVEAMARRCFEQFLFADMNACGAGVLPEGVGSMHNAVLDGPLVLQVDEIVNLSAPLRERYRDAHAGPKRCLKLSMTDGIQRIYGMEYRPIKDLEVLAPAGFKIVIRNVHIRRGLFMLVPEVIEILGGVDDELDEARNRLVSEVNKPPRGKRKQGGLPLSSRATLAAWPTNANATNDAEQGASVPRTVNTPHPTRLGNASHASQVGRTTQPMVDNLIPHVVVSNAQEQSRHIQEITMQGQPTSLNRHNKEASASYRYNAQCSISGTTRAMADEHVLVSNAQEQSPHIQEITMQDQSTSLNGRNKEASASTSYRYNAQCSISGTTRAMADERVDPSFVGNNVHEQMQRVQGITMQDHISASSESKRELSVTTPSGYDSRLAPHGVGNTGTRSGEATRSSNVDDGINNIGHPISLCGENEKPFTYIFNMLADWGVQQDTVPYIQGKIKGLITSVKRFQYKQSMQYDLYVYIDDGSFITEAFVDRDIVQNMIGLSAEELAAALSSGGPAQANIRKTMKAFEHFLVNFEGTILIELNRDSSVPIVREMNKGCSSSDAWQLLRRVKTFSGQGYMRSLDFMDTTP
The following text describes a protein:
Function:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Domain:
The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven.
Sequence:
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
The following text describes a protein:
Function:
Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
Subcellular Localization:
Cytoplasm.
Sequence:
MRLLSKAAHPDGSMEVRVSVGTAEDLWHLYNFILVGDLVLTKTRRKVPRENALGTLAAEMKMLKLEVEVKHIAFTPDELRIQGVNKKENNFVKTGAHHTLTIHANPPQEVRITKREWDSICEDRLKDACDESGKADTAAVLMSFGEAQVLLVTRSFVHIKAKVEVTISKKHKSDGKARDKSIERFFKQSLDALVTHVDFEKTKLVLLCSPGHVREEFHAYIKEVTQRADHGPLREVYLNLSRFLLVKVSSTTISGLKEALSDPGVAQRMESTKCVDDIRMWEKFQDTMNKDPDRCVYTPQYVYYAAMAGAVGGLMISDDVFRSENPTERRFFLSLVNFVRQSGSPTVNVFSSKHVTGEQLTQLGSVAAVLRFSCPEIDDMEVVPEFLASKEVEEFIRANATARVTV
The following text describes a protein:
Function:
Functions as a component of the transcription regulatory histone acetylation (HAT) complex ADA. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. AHC1 is required for the overall structural integrity of the ADA complex.
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMSPAQDKLQHQHHNPNSSSSSSSKMTNVYQVTTPKSPQDLENNMDEPFKMDTATSNPDKDSENTQRLKYECAKGEIQNVLNLHIMLNHKHVRHLRRNVQKVNAKLALLETLHKDTGLLNKIERTYQLKIKQHQQHSVLGGHFHDSTATENTNASNYNLSYPVLSDYNINCQPLSSSSNRNLSTTRIPHHHYHTRSKSNGLLLEPSALRPANSNIIDYRLTGSKSLSEAITKPTPVSLPHSNSDGISSPRSSSISPLDEQPGFQILPFKPSQMHLNHRRNYSSTCLTSNSGIIGKTENNEPIFRRYDGILVIITCSKCDRSGFTSAQGIVNHTRLKHSKLYSSQPLAVLNNQKLLPNDKQDPEILSKFKKLNLDPNKDYLPSDIAIPKPQSPINHSENHTRAPKTVKNTPHLEKLYQNKEDFKKLIDMVNETPDDLNEYLKQREIQLRYQKEQEEESSKSDDEASYVPSPSLSATATTTTTTDPPSPPVLSSSLQRKLLRKRKLSLNSSTPMEDLPLRERLRANPTDKKPRKAALLTNELEGPDPAAKSSSYYNLRSKSRLRGSHT
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MMGYQTNSNFSMFFSSENDDQNHHNYDPYNNFSSSTSVDCTLSLGTPSTRLDDHHRFSSANSNNISGDFYIHGGNAKTSSYKKGGVAHSLPRRCASCDTTSTPLWRNGPKGPKSLCNACGIRFKKEERRATARNLTISGGGSSAAEVPVENSYNGGGNYYSHHHHHYASSSPSWAHQNTQRVPYFSPVPEMEYPYVDNVTASSFMSWN
The following text describes a protein:
Function:
Controls photoperiodic flowering response. Seems to be one of the component of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. The particular coordinated sequential expression of PRR73, PRR37, PRR95, PRR59 and PPR1 result to circadian waves that may be at the basis of the endogenous circadian clock (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVGAGEGDRVGGGAAVGGGQQFVDRSKVRILLCDSDPSSSREVLRLLCNCSYQVTCAKSPRQVINVLNCEAGEIDIILAEVDLPVSKCFKMLKYIARNKELRHIPIIMMSNRDEVSVVVKCLRLGAAEYLVKPLRMNELLNLWTHVWRRRRMLGLSEKNFFNDNFELALSEPSDANTNSTTLLSDDTDDKPKENINQETSTSNQHEYESNPSDAEPKQKGTPEGLLVSTEGGDQASSPGVMFSRPIKTNLRVAESSAFLAYVKSSTPTTSSFDSELQKGGNRLDSSDHRGNFSSTTDRSDTGTDVNIRDKEAFEMPVQYPVVCFSSSNLHLERSNEGQNDASGTPPVYHFPFYYPGMMDHGMTHPPVQNFQGNINNAQVHTPQTLLPQYNVYPQCHGVSMMPPFQYNPAGMSIQSNQLPTQNMWPQASSTPMPEETCSRSERRAAALAKFRLKRKERCFDKKVRYVNRKKLAETRPRVRGQFVRQANYTDITSTGDDISEDEDDDPSSREVEMVSSPE
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAAAQLVTSLVGENVILQTALVLLLVFVATSWFFSTPKNLPPGPRGWPVVGNVFSLAMGHRFLTMTEWAKMYGPVYTIKLGRETTVILSGYDVMHEALVKRGEDFSTRPTDPLTKLLNPQRLGIIAAPFGTPWKEHRKFTLMSLREFGFGKRSMEGKILEESVALQAEIIKMGNKPFDISRMVQNAVTNVICSIVFGSRFEYNDDKFTRLMDVLDRAFSLNVFGQIAVFFPFLRRVPGMGKGPQVLIDLVGTIRAYLREEMDSHKKTFDSNDIRDLIDSYVRETKSRENDEETTFTDEYTERVLFDLFIAGAETTSTTLYWAFLYMILNPDIQTKVQEEIHSVLGHDKPPSTAHRAQMPYTEAVLTEVARIGTILPTGVTHATSRDTSFHGYDIPEGTLVLPNLWSVHHDPEHFPNPGMFDPGRFLDAQGQYQRDDHVMPFGIGPRICLGKQLAEMELFVFFTSLLQHFTFKLPEGAAKPTTTGMNGLTHSPKNFDLVAEPLA
The following text describes a protein:
Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MSAKLKVDELRAELSHRGLNTSGTKPTLVRRLDAALRKEKREAEASDKADSLTDGVSKGAKKRRKDAAGDAMVENAEEDEGGNKEEKRVTMTKKNGAVLDPFLPDHIKSSFHVLNKGEEMYSATLNQTNVGNNNNKFFVIQVLESDDGIRYMVYHRWGRVGVRGQDKLLGPYTSQEAAIHEFEKKFYDKTKNQWCLRKEFKCHPKCYTWLEMDYTDSENGTAPDKTCQSSSSQLRATKLDSRIAKFISLICNISMMKQQMLEIGYNAEKLPLGKLSKSTILKGYDVLRRISEVIAQSDRKKLEELSGEFYTVIPHDFGFRKMREFVIDSSSKLKRKLEMVESLAEIEIATKLLKDDSETQVVLMLKDDPLYCRYEQLHCELSPIEADTNEFAMVKKYLLNTHAKTHSGYRVDIVQIFKVSRKGELERYGKFSSTKNRMLLWHGSRLTNWTGILSQGLRIAPPEAPVTGYMFGKGVYFADMFSKSANYCCASSQSRDGVLLLCEVALGEMAELLDADYNADRLPKGKLSTKGVGATAPDILDSQILEDGVVVPLGTPKEQNNLQCSLLYNEYIVYNIEQIRMRYVIHVLFDFKN
The following text describes a protein:
Function:
Ubiquitin-like protein involved in autophagy vesicles formation. Required for atg8 association to the vesicle membranes. Conjugated to atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme is essential for its function (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MEEEEKNNNEVASPTEQNTESTTEQQPQLPVKITSESKIIVYFKNAGGAQPLKQKKFKIQANVSFQNVIDKLRGQLKLKSNESLFLFINQVFQPSPDEILGELYKCFSHNDQLIINYSLQMAWG
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular Localization:
Nucleus.
Sequence:
MPSEFSESRRVPKIPHGQGGSVAIPTDQQEQLSCPRCESTNTKFCYYNNYNFSQPRHFCKSCRRYWTHGGTLRDIPVGGVSRKSSKRSRTYSSAATTSVVGSRNFPLQATPVLFPQSSSNGGITTAKGSASSFYGGFSSLINYNAAVSRNGPGGGFNGPDAFGLGLGHGSYYEDVRYGQGITVWPFSSGATDAATTTSHIAQIPATWQFEGQESKVGFVSGDYVA
The following text describes a protein:
Function:
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Sequence:
MTTRTVQRNLWASAAVVLVLLLLWTDTTGGYFAAIDETETSKNCFCELEGSINDCSCDVDTVDHFNNMKIYPRLQSLLVKNFFRFYKVNLRQECPFWPDDSRCAMRFCQVENCEEQAIPQGIKDKGEHKEKAAFKYTREAQVGGSACSDGEDFDSSLGFLDTSISDQAHREFELWAKHDEAEEDFCIVDDHEEGSQYVDLLLNPERYTGYKGESAHRIWKSIYLENCFGGNNETANKFSNYVPHLDLRNVCLEQRAFYRIISGLHSSINIHLCSKYLLSESKDFLDPQGIWGPNVKEFKRRFSPETTSGEGPHWLRNLYFIYLIELRALAKAAPYLRREDYYTGIAEEDDEVKLAINDMLSVIENFQSHFDENALFSNGIASIKFKHDYKEKFRNISRIMSCVGCDKCKLWGKLQTQGLGTALKILYSEKLNLATESGLWDKPHIEADPIFRLSRTEIVALFNAFGRLSNSIYEMENFRCVLR
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MRKYHSLLPVLLGFAVLNSFVGCVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEALRMYLSSVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEGNQSILVDLVKMVPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQQSDYQTAAKWYRIACKRELENPEQLFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEEAFIMVQASQEELDNIMSDLNEPQNDVEVEKDLYQVKRSPSNCELGCRGLYRQKTNLVCRYKSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELKGQSMNMVNGYASQRNGTEIRDTVVRYDWWSNTSLVRERINQRIIDMTGFNFLKDEKLQIANYGLGTYFQPHFDYSSDGFETPNITTLGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFSFPCKS
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MSPRSTSVGSLAAALLLWTGIATGANLPTFSSLEDATLVHRTCQTIQKGTQAVQGCVLRGNGKWQVALGATEGSDCAATGTFIDSSQTTSNFGKLRVVTGAGGGYTDLEQAYAAGFLEGYLTAARIFDHFSNLKTYFNTMLNETEMVEKSLDWLEVQEAWVNEQLKSAPADDPYWRLLGLVQRQFDGLVDGYQARAQQEEAGQKQQHQQGQRQAGRKAGRRMAPGGGTGSGNEDVAVGWLERRDMMFLNSNGDVYDIIDALEAGYGYGDDDGSAGNAARPGGARRGRRYPSFADIDESPMRMSLKLGLQGKCSALIKVTGDLTDLLVGHSTHDSFTAMTRIYKHYDFSSLADDAITARRVSFSSYPGELFSDDDFYLLSTGLMVLETTNHIYVGDVYAPLQPHCVLSWQRIRLANWMAATGEEWVDVFGRFNSGTYNNQYMVINFNRFVPGKELQPGLLWVVEQLPDIFLTADMTQELARGYWPSYNVAYFPEVYEAAGYPDMIARLEAKGAKKYAFPIRLLKYQIAPRASIFRRDQGAVANMDSLKRMMRYNDFQKDPIADGNPVGAVCARGDLATGKDGIAKGCYDSKVTTASMALRMESEVIGGPTAQGQPPFSWSDPRWVNLPHRGMPDTFDFAFERMSPKDLPTTPECTEAAKVVAAGAASIGVGQKAHLQQLHAADVGSTSSV
The following text describes a protein:
Function:
Plays a role in spermiogenesis and fertilization.
Subcellular Localization:
Nucleus membrane. Note=Located throughout the subacrosomal area.
Sequence:
MENFSLLSISGTRISSSALSTLPDIMSSRATSLPDIAKPVLPTEVPSPVQALPPQCPGGVLRHGVHNIVISPDCILGDAPNGEQLRWNCTIYRPWFSPYSYFLCKDKESHLETYSFSEVQRDEGQRDSCLPEDTADSVCSSSPSPENTCPREATKKSRPGPDTTDSITFQDILMASKWHPAQQNGYKCASCCRLYPTLHSLKSHIKRGFKEGFSCKVYYHKLKTLWYKEQKARPGDRLSLGSGQAFR
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSDALPIEVTSPTPLLELRGISKEFPGVKALDDVSFAVFPGEVHMLLGENGAGKSSLMKVLCGAYRADAGEFYYKGEKVAIGSAADAQKLGIAVIFQEFSLVPHLDIAQNIFLGREPKGRIPGTIDRSKILADAKRVLGTIGFDIDPSTIVDKLGVAQQQMVEIAKAISQNARILVMDEPTAALSDRETELLFALIARLKADGVSIVYISHRMAEVFALGDRITVLRDGRRIDGVRPADVTPDQLVRMMVGRTVDMTYPRNFADKPGEVLLQVKGLSSSTGISDINIEVRRGEIVGLCGLVGSGRSEVARAIFGADPVSSGEIIFDGKTISGEPDLAARRGIALIPESRKSEGLALLRSVSDNLVVSALRKLFPSGLFDQRSAQRTSDGLIRQLRIATPSARQTVGLLSGGNQQKVVIGKWLAAGSKLFIFDEPTRGIDIGAKSEIFALIDRLVAEGAAALMISSEQVEICHVCDRAYVMREGRIAGHLTRNELTEENIVRLGMHHA
The following text describes a protein:
Function:
Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization. Cannot compensate for loss of other members of the Obox family, suggesting that its function differs from other Obox family members. May regulate expression of histone genes in embryonic stem cells. Also involved in completion of meiosis of oocytes during the meiosis-I/meiosis-II transition. Required to maintain the nuclear membrane of the germinal vesicle in oocytes.
Subcellular Localization:
Nucleus. Note=Nuclear localization is dependent on its homeobox domain.
Sequence:
MSKDSSLHPKYQMASNIPRETSFLVPKEPTRYLPFQMCQSPLVTPTRPLQSSHSVHERDLHQKDSQEPSRNSGSMPLSDKYYNKQSGPVATRKCRKERTVYSKEQKCLLQEHFHQCQNPDLEQRKALALLIGVTEYKIQTWFKNRRAKECRKSSQLPRRIGSGPHYRPTSSSGGEVPDFAASPDSVCQRHVNVSYPPEFRPSRNSPHQEFNSSLIDQPLEDMCFSKSHIISEHPRQKCRELSREPGHLSSDRSGCSNVLSSPSPAAGAESSCDIPSGLSLSPQLGPPSMTQNSESTFSMCQTPSVLSPLPELSPLSNSLDQMAIFSKIDQVCEIYQKNTRSKKQRKETEKNTVQNLMHGQDSCEITESPKGTVSLPSSAY
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MQMLTKFESKSSRAKGIAFHPTQPWLLTSLHNGTIQLWDYRMGTLLERFDGHDGPVRGIAFHPTQPLFVSGGDDYKVNVWNYKTKKLLFSLCGHMDYVRVCTFHHEYPWILSCSDDQTIRIWNWQSRNCIAILTGHSHYVMCAAFHPKEDLIVSASLDQTVRVWDISGLRKKHATPISLSLEDQLTQSHSSISNDLFGSTDAVVKFVLEGHDRGVNWCAFHPTLPLIISAGDDRLVKLWRMTASKAWQVDTCRGHYNNVSCCIFHPYQDLILSVSEDKTLRVWDLNRRVAVKTFRRENDRFWFITCHPKLNLFATGHDSGVMVFKLERERPAYALNINTLFYVNKEKSIVSYDLMRGTSNALDSVKELGSSWIPPRTLSYNPAEKLALVTSTADEGTYELVGLSNRNKSDTNIRDKGDNAIFVARNRFVVFKKEESVLELKDLSNKTTKVLQVDSIKPNDICYAGVGNILLFSENHVCLYDLQRAKITNSLKFRKVKYAAWSHDNSQIALLSKHYIKIVTKDLKEVTTIHETIRIKSAIWQDNNILLYTTLDHLKFALLSGDTGIIQTLESTVYLTKVKGSTVYALTRSAEPITLEIDPTEYLFKLALLKKDYEKVLQLFQTSDLIGQSIISYLQKKGYPEIALQFVEDPSTRFELALECGNMSVALDLARTIDRPEVWSRLASESLNYGNHRIAEVAYQKLRNFERLSFLYLTTGNQDKLQKMAAIAEKRGDYLSTFHNSLYTNDAEQRVRLLVQCNMKPLAYLTAKSNGLEEIANEILAETDMTEDKIKMPTLGARFTTPTVVKSTFEENWPLKSSSEATFERLLQEKMEQLIIQEPMDMVTAGESEDEFQDTEQALSDDEEAEALEQDEEQAEDGWEVEDIPLDEELVAITADDASAVNLEEVDLWKRNSPLAADHIAAGDFEGAMKALNQQVGAVNFAPLKDRFLEIFQAARVYAPMFDTLEPLTVYLRRNKESEFDRLKTLPFIARNYSSCEANELSDAYRLFKENKITEARELFIKLIHILILTVAEDKEEAENLSTLIDECRSYVVALSCELARREMKDEDAKRALELSVLFAAANMQPVHSTIALRLAINLAHKQKNFKTAAFLGKRLLEITSSESAKQAANRAILLGDRNPHDEVELDIDFNSEIYACAASLSILYPSSSQVTCPLCGAAYLPKYAGQLCCVCKVSNVGATARGRRFF
The following text describes a protein:
Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Also represses multiple types of non-EGR1 activation domains (in vitro).
Subcellular Localization:
Nucleus.
Domain:
The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization; The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Sequence:
MATALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCNSYERSSSAREPHLKVPKCAATTCVQSLGQGKSEVGSLALQSVSESRLWQGHHTTESEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKNNKKLAKMIGHIFEMSDEDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQVSREVTYKYTYRTTRLKCGERDELSPKRIKMEDGFPDFQESVPTLFQQARAKSEELAGLSSQAEKGMAKQMELLCAQAGYERLQQERRLMAGLYRQSSGEQSPDGGLPSDGSDGQGERPLNLRIPSVQNRQPHHFVVDGELSRLYSNEVKSHSSESLGILKDYPHSAFTLEKKVIKTEPEDSR
The following text describes a protein:
Function:
Acts as a transcription factor that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many promoters. Involved in the development of the excretory duct cell, by positively modulating embryonic transcription of putative transcription factor lin-48, acting in concert with cell death specification protein ces-2. Negatively modulates expression of key autophagy-related genes, bec-1/ATG6 and lgg-1/ATG8, and may link together autophagy and apoptosis during development. Positively modulates expression of neuropeptide pigment dispersing factor homologs pdf-1 and pdf-2.
Subcellular Localization:
Nucleus.
Sequence:
MDVDSASLSPSSRLSVVCSASAEFSSSSSDSSNFSEGSPPESRRNSVNESVIKDEHYWERRRRNNDASRRSREKRRQNDLAMEEKIMLLSAENERLKSQLGTTPIPQPSVTEPPTSLIIPQVAKNLFPAGPIASLQASSMLTVPLLQAASHIPSMLQLCQLQPTTIQSPVYASTQQPASTSASSLFSSSSSSAFHPFRPSESAQQSFPSSSVIVKIERRSPDSSTDVNMPQPQLQPGSSVIQQIGQPAPSGTPQPVIQAVQQGPSLLSALLSQRRPSPTVPQSRTEHISGLNSPPRHTGNKSDCESVSSSASFSPSHSSEDHSNYSNKSPQYVDRRRRNNEAAKRCRANRRAVFEYRSRRVQLLEGENEDLRTQIETLKAEIAHFKSVLAQRASVVTALHP
The following text describes a protein:
Function:
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity). Plays a role in the maintenance of heterochromatin (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 1590 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MEQHLKSIPLQDDTKKKGILSFFQNTTTVKSNKFLTKEKDVITLDDPKEDVSGPMIETVKQETMKSINKECADEMKTTPKKANAEDKLLCYKNSPIQSTKYDRNTNKQVPNGNIIAIETKSRSSSPCSKRELSSSKKEEAKREKELKKQQRAEEKHRKELLRQEEKKKKELKVEEERQRRAELKKQKEEEKRRKEEARLEAKRRKEEERLKKEEEIRLKEEAKERAQSRIGNFFKKLSDSNTPVVEKSDYEKFFLPFYAKDGVRVSNKWKLTKVELEGSKRKIDDELLNSKDKTSSDDLLNWLQSRRLPRGHKIKRKAVDVLQQMPLKEKTDDELQSLLAQVPHKYIKFYENVRPPFIGTYSMDFTLPPNDPFSTKGTGFNYDYDSDVEWVNEEEEGEVDNLESGEEEEEEEDDEDVPSEGEFDGFLDSEENSDLDGLPCAKRKFVGPLIPTICLKSNFENLSEENKRYLQQLKAEVIIETDGPIDPFKEPKTSSLPSKRSNSDLQAQTASQSQSPEKKQKAMITDPMDLLRLFDGVQDSTFSLGTVTEIAQKNLPQYNKQTIKNTIKEYAIRSSGKGDLPRKWVIKDAQNWENLRANANMPTPSL
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MMKRAIAIRNSTANDTGGNNKISLSPSDLETVTDKYATSSPPLTLMRVMGFFVISFMLFSVLFSLSVVLRDPPSDAAFREQPSSLFQLQQTQQGLDSDASHSGELLNDKLLGGLLADGFDEKSCLSRYQSAIFHKGLSGKPSSYLISRLKKYEARHKLCGPYTESYNKTVKQLGSGQFTESLDCKYVVWISFSGLGNRILTLASAFLYALLTDRVLLVDPGVDMTDLFCEPFPDASWFVPHDFPLNSQLNSFNQDSNQCHGKKLKTKSITNSTVPSFVYLHLAHDYDDHDKLFFCDEEQLFLQKVPWLIMKTDNYFVPSLFLMPSFEQELNDLFPKKENVFHFLGRYLFHPTNNVWGLVVRYYNAYLAKADERVGIQIRVFDTEPGPFQHVLDQILACTLKENILPDVNRGQNINSSLGTLKSKAVLMTSLSSGYFERVRDMYWEYPTMTGEVVGIYQPSHEGYQQTQKQFHNQKAWAEMYLLSLTNVLVTSSWSTFGYVAQGLGGLKPWILYKPENRTAPNPPCRRAMSMEPCFHAPPFYDCKAKRGTDTGELVPHVRHCEDMSWGLKLVDN
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMNLSRAVVRSFATTAGRRSAAVPKDQIEKGYFEIRKVQEHFQKKDGKPVFLKGSVVDNVLYRVTVALALVGIGGMGKLFYELSVPKKE
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MDSDHRVGDLVRQLVHHLQNTSSSNPNPEDVNYAIRILSSRMTPPSQAADEANSIKSRLAKQSKLSHALTFADLYSKFASKTGPGSVINKQSLLYLLKVISEDRVTNPHPKSRTDSCYNLLKNGGVLNIVRNPNNTVVRDFARLVSEESDVLEKDLVSDVLSVCEGIHGKYVKFDEMLDSYVLSESIKVSKGMRIMVLKLCELGWLFRKVNRYVCDDIGENVGKSFRVGLQDEVVEYRKLLTVLQSQSLNLSLRRLAVWFVEPMVKMRRMALLVDSCKDLKGGALAGEIHLHAQHGDPLLHEFMKRLLLKVSSPVFEMVRSWVMQGNLQDLHSEFFVSEQSVKPELLWKEGYQINYLMLPSFISKSLATRVLRTGQGDFVQYLMETVGPVLAEPAKTISLIHLSGLVEKAILSSGAQYDDRDILDRIKVKMMMPHGVKDRGWDVFHLDYDIRVPLNTVFTESVMGSYLRVFSFLWKIRRVEHAVLGAWKTMKPNLTSCHVFTNYPKAVGLQIVSTSRKCQLLWDKMNNFVMSMQAYIMFEVLEVTWAKFCNEMEASKDLDDLIAAHEKYLVTIVEKSLLGETSEALYKALLMLLDVILRFTSVADRLYEFRTRNTATSKTKDANKTSKSKGLETDSWLNEGRKAVTQRAGEFLSIIGQDLDAVSKEYSSVLKGFISQLPTQRHVDLKFLMFRLDFTEFYKLAA