lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=Vacuolar and perivacuolar punctate structures.
Domain:
Contains a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2); The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway and for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium and in both its recruitment to and dissociation from the PAS under starvation conditions.
Sequence:
MVTINDLSFNPDYSSISVSTSDGFKIFNCEPFGEFYSSQESPLRKSISNSLEDSAGCQNPTHSKTDSQDTPARFPTAFLKMLFSTSLTIVVPQTQDNLGNRLLKIYNLKQNLKICELNFPSSIIDIKLNRKRLLVVLDTGQLYIYDLSCVRLLKILQLSFNEHDGDQKFIGDLSADDSSWLIIPVQSTNNQTDLLNAETGSQPSTPKLTPSDSVINTGSYSQYLEFTRNSSLSNLKKKNKLITLEDIKNDSEGWVVVYDTINLAPVVIFEAHHSTIARICISHRDNKVATASIKGTIIRIFDLKEFEGKVKVHKVKNLRRGHNLVKVNSLSFHNDNHILGCGSESNTIHLFKIHEEESDICTNENSEDRTNHNSDYEDSDGDTSKSSEDLNENLANLLISKPLDPVPMETEDKLSSSWFVKTKKLINNQYTSSIIKKLPYKDYFENLIWEPPQRSFAYIKLPEYAPHNEKDPRSNKVEIGFNNDLVFIASYHTGNFYQYQIPKQRGPVSSINEDDKREECSLISQFNLI
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Sequence:
MKRTIQSIRITRNTINTFSSQTTTNINQQQQQQQQPKQQQPKQQQQQQNHHQQPPHYQQQQQYYQQQQQYYQQQQPYQQNYQHQQNYQQQQYYQQQQNYQQQQPYYQQQQQQQQQQQQQQYYQQQQHQHGEPSFRRPSTNRFPEPPKTNKFENSNVNTNNQPNTNNHQLLKKRKDEEKKLRRIGVLPSHIKPKPKSNEIIISKLAQEKKQRKLLLESSKNHNINTTKNNLTSKRELAIPSAITVAQLAQLTHQKLYRLQSLMQSAGLLDTRPDRILSTDDTAYLVLESGYEPIVNDTLAYDIYPDGPSVDRSRLVLRPPVVCIMGHVDHGKTTLLDALRKSAVAASEAGGITQHIGAFEVSLKDLMAAGSANADADPAGEGPQTITFLDTPGHAAFSAMRSRGAMTTDVAVLVVAADDGVKPQTKEVIELVRQTDIGVVVAITKCDKPGIDLHRTRAGIYDAGIEVEGLGGEVPCVEVSAVSGKGLAEIAETILAVAEVRDLRAEEEGVRFEGRVIESDVERGHGNMASVITLRGRLEVGLDIIAGRSYGRVRQLITVSGEPVSEVSPGRPVRVTGWKSLPEAGSLVLGVESEEQAKRACENRVRRFEELGLAEQIELVNERRAQAREAFETGKAELEGMTRRERVAHLRERNQQASAQAKIDSRNEEDSPDCLKLVLKADYTGTVEAVRTAIESLGNHQVKVKIVSSGVGNISESDARMAIASGAQLVGFNVKIDPMAFSPIESHKVKYTIESVIYRLVDSVTQDLVKLLPKRYKERVIGEAKILQIFEINSSSSSSSKIKSKVAGCKVSNGEIKKSCSIKILRNKEIIWKGQIKDLKQGKKETSQIAKGQEFGISFKESDHPVPSTTNNVSEPASNSNSNNGKNEEGSGGNVQGISGQTFDRFDVNDEILAIEDVLLERTLNDGL
The following text describes a protein:
Function:
Mediates magnesium influx to the cytosol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MGSNKLPAFFGLNNHLYPASLNPVRENLIQKHDSGTPKHRSMSSVFASLRSLLSGKKPDGGKRTEEEDKVYNWLYALAQSDKDLVFEYVKSTERGLSFKEAERRLRENGPNVPVDYTFPRWWQLLWNAFFHPFNIILIVLSFLSYVSSDYPNGCIMLMLVFISVALRFFQEFSSSKAAMKLSEYLRCPVKVQRCAGRIVQTELIVQIDKKDVVPGDIINFGPGDLFPGDVRLLTSKDLVVSQSSLTGESGTMEKVADIKEYPTTPLLELRNICFMGTSVVSGCGTGLVVSTGSKTYMSTIFSTIGKGKPENVFEKGVRRVSYVLICIMLVIVTIIILSEYFASHDLSESIIFGISVACALTPQMLPLVVNTSLAKGALAMARDRCIVKSLAAIQNMGTMDILCIDKTGTLTMDRAIMVHYLDCWCLPKEKVLCFAFLNSYFKTELKNPVDDAILAYAYTNGHKFEPSKWKKIDEIPFDFIRRRASVIIETDTKANNRNNHGPNRFMVTKGALEEVIKICSSVQLIDKGETLPLSPEEHQRILNIGEELGNDGLRVLGVAIRRIRQECNGFHVMNNEKVEADMVFLGLLTFFDPPKDSAKQALWQLAEKGVKAKVLTGDSLSLAIKVCKEVGIRTTHVITGPDLEVLDQDTFHDTVKRATVLARLTPTQKLRVVQSLQTAGKHIVGFLGDGINDSLALDAADVGISVDSAASVAKDFADIILLEKDLNVLVAGVERGRVTYGNTMKYIKMSAIANVGSVISLLIATVLLPFEPLAPRQLLTQNFLYSVGQIAIPWDKMEEEYVKLPQRWSPKGLPIFMLWNGPVCSVCDAANLLFLCFYYDASSSSKRSFFHSAWFVEGLLMQTLIIHLIRTEKIPFIQEVASWPVICSSIVISAVGIAIPFTPIGKIMGLTNLPLSFFGFLIVLFLGYFSLGQVVKKAYIIVFKEWL
The following text describes a protein:
Function:
Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'.
Subcellular Localization:
Nucleus.
Sequence:
MQRMIQQFAAEYTSKTSSTQDPSQPNSTKNQSLPKASPVTTSPTAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCASSTSLSHSPGCSSTQGNGRPGRPSQYRPDGLRSGDGVPPRSLQDGTREGFGHSTSLKVPLARSLQISEELLSRNQLSTAASLGPSGLQNHGQHLILSREASWAKPHYEFSLSRMKFRGNGALSNISDLPFLAENSAFPKMAHQTKQDGKRDMSHSSPVDLKIPQVRGMDLSWESRTGDQYSYSSLVMGSQTESALSKKLRAILPKQNRKSMLDAGPDSWGSDAEQSTSGQPYPTSDQEGDPGSKQPRKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKERLGTLKNPPKKKMKLMRSEGPDVSVKIELDPQGEAAQSANESKTE
The following text describes a protein:
Function:
As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MVNQMRSAIVKVFSTKHSLTLPAPALHYIEEVLIENEIPEDEWMVGLEFWAKEYLKAEDSSSLVSLQALKKAYENLQLGTTEDTQVADPSEVNVESHFSVVDSFDMPAMRYDPVRSGFVQSKAQPSVAGQASSRSAFLRERWAIIKEIILRNENFTPPAIGGHDRANYLKLTSIRNLLGRAGQLFLLFGMLARNEEGKLCLEDGESRVVLDMEDAVPGEGLFTEGCMVLIEGEYTVEETVRVLAMGHPPSERRNIARSLHGHVDFLGGGAVSLKEEQKYNPTVLANTQISFVILSDVWLDHPRTMPALRQMFEGYANTAEYRPMVFVLCGNFCQGGWEGQEGLKRYSRGFNSLAELLQSIPLLHSSHFVFVPGPSDPWSSTTLPRPSLPSAFTTRLSNRIPNARFVSNPCRLKYFGMEIVICREDLMGKMMRNLVVVKEGEEMNMKRYLVQTILDQAHLSPLPISVRPTLWEYDHALRLYPMPSAVVLADKYERYELTYEGCHVFNPGKFVGGIGEDGWEFEWSMYYPATGRSERSVLTME
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Membrane.
Sequence:
MASLRTFDAFPKTDQQHVRRSSRGGIMSIMMYLFLLFIAWGEFGSYFGGYLDEQYIIDPELRQTTQINMDVMVQMPCKYLDVKATDITRDINDVSKRLVFKNIPFFVPYGTTFDSVNEVRTPDIDGMLADAIPLKFRENIPDADLPEEFEFNGCHIYGSIPVNRVKGELHITPKGWRYSSRQRVPHDEINLTHIFNEFSFGEFFPYIDNTLDQVGRYAQQRLTRFHYFVSVLPTIYRKMGAVVDTNQYSVSHNDITYTSSRLYTPGIFILYNFEALTVVVQDKRISFWAFLIRLVTMLSFIVYIAAWAFRLVDWLLISTLGPRWSLRYGEPHDSSKGLLE
The following text describes a protein:
Function:
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation. Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination. Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.
Domain:
The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (DXXLL motif); The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis; The unstructured hinge region contains clathrin-binding and an autoinhibitory (DXXLL) motifs; The GAE domain binds accessory proteins regulating GGAs function.
Sequence:
MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL
The following text describes a protein:
Function:
Bcl-2-like protein which targets host toll-like receptor signaling complexes to suppress innate immune response. Interacts with host TRAF6 to activate p38 and subsequently induce the expression of several cytokines such as IL-10. Also associates with host IRAK2 to inhibit NF-kappa-B signaling.
Sequence:
MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMFTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS
The following text describes a protein:
Function:
Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.
Subcellular Localization:
Virion. Host cytoplasm.
Sequence:
MDRQPKVYSDPDNGFFFLDVPMPDDGQGGQQTATTAAGGAFGVGGGHSVPYVRIMNGVSGIQIGNHNAMSIASCWSPSYTDRRRRSYPKTATNAAADRVAAAVSAANAAVNAGAAAAAAGGGGGANLLAAAVTCANQRGCCGGNGGHSFPPTRTPKTNATAAAAPAVAGASNAKSDNNHANAASGAGSAAATPAATTPAAAAVEKRRPSPSPSTASTAPCDEGSSPRHHRPSHVSVGTQATPSTPIPIPAPRCSTGQQQQQPQAKKLKPAKADPLLYAATMPPPASVTTAAAAAVAPESESSPAASAPPAAAAAMATGGDDEDQSSFSFVSDDVLGEFEDLRIAGLPVRDEMRPPTPTMTVIPVSRPFRAGRDSGRDALFDDAVESVRCYCHGILGNSRFCALVNEKCSEPAKERMARIRRYAADVTRCGPLALYTAIVSSANRLIQTDPSCDLDLAECYVETASKRNAVPLSAFYRDCDRLRDAVAAFFKTYGMVVDAMAQRITERVGPALGRGLYSTVVMMDRCGNSFQGREETPISVFARVAAALAVECEVDGGASYKILSSKPVDAAQAFDAFLSALCSFAIIPSPRVLAYAGFGGSNPIFDAVSYRAQFYSAESTINGTLHDICDMVTNGLSVSVSAADLGGDIVASLHILGQQCKALRPYARFKTVLRIYFDIWSVDALKIFSFILDVGREYEGLIAFAVNTPRIFWDRYLDSSGDKMWLMFARREAAALCGLDLKSFRNVYEKMERDGRSAITVSPWWAVCQLDACVARGNTAVVFPHNVKSMIPENIGRPAVCGPGVSVVSGGFVGCTPIHELCINLENCVLEGAAVESSVDVVLGLGCRFSFKALESLVRDAVVLGNLLIDMTVRTNAYGAGKLLTLYRDLHIGVVGFHAVMNRLGQKFADMESYDLNQRIAEFIYYTAVRASVDLCMAGADPFPKFPKSLYAAGRFYPDLFDDDERGPRRMTKEFLEKLREDVVKHGIRNASFITGCSADEAANLAGTTPGFWPRRDNVFLEQTPLMMTPTKDQMLDECVRSVKIEPHRLHEEDLSCLGENRPVELPVLNSRLRQISKESATVAVRRGRSAPFYDDSDDEDEVACSETGWTVSTDAVIKMCVDRQPFVDHAQSLPVAIGFGGSSVELARHLRRGNALGLSVGVYKCSMPPSVNYR
The following text describes a protein:
Function:
General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
Subcellular Localization:
Golgi apparatus. Membrane; Single-pass membrane protein. Mitochondrion.
Sequence:
MAGAGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGQHAPKDLKEEIDIRLSRVQDIKYEPQLLAEDDSRLLQLETQGDVPITAGTSVGLLSVRHIRGAAVSQAHPWGCCQAHPWGWARGRALAGPVGQLGVSLCSAQPSVWFLSFPGCYNYLYRMKALDAIRTSGEGQRGRSAGTKQGCIGQRLGSPSVIKPPHPPPPGLAVLSHWQQALIGGSRVGGGLMNEPRTFSFAVCFTQLCCTFCFPEIPFHAEGRYPKSLIGKNFCAYLLELRNSSSSFKGIRKALIDTLLDGYENARYGTGVFGKPEYLKYQDALNELANMTKARAGSSQRQHQSAAKDLTLSPEVSNPATIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL
The following text describes a protein:
Function:
Possesses activity on acetaldehyde and glycolaldehyde in vitro.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MADHCNGSSHSSESFANIPPIKFTKLFINGNFVDSVSGKTFEAIDPRTGEAITLVSKGDKEDVDLAVKAARFAFDNGPWPRLSGSERGRILMKLADLIEENIEEIASLDAINGGKLFSLCKLIDIPAASMALRYYAGAADKIHGTVLKLSKGLQGYTLREPIGVVGAIIPWNFPTIMFFMKVAPALAAGCTIVVKPAEQTPLSALYYAHLAKLAGVPDGVLNVVNGYGETAGAAISSHMDIDKTDKKQFEKILSYIEHGKREGATLLTGGKHIGQKGYYIQPTIFADVKDDMIVAKNEIFGPVMSLMKFKTMEEGIKRANNTTYGLAAGVITKDLNVANTVSRSVRAGIVWINCYAVFDMDCPYGGYKMSGFGRDYGLDALNQYLQIKSVVTPIHDSPWH
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2.
Subcellular Localization:
Cytoplasm.
Sequence:
MITSRNNDIGNLIEQFRQRDTPQKERKAILARIEEILQTTKNVESLCVKWTYLLDNLCWPSLTKHDRNDMKTLAGKVIRLVGVLLFDTESYPEFLIYLGTLYQSVTKKSEETRADIVFSVYFIVGVISQKTENRLIATDTENVEKSLDWIIKVLPNSSISVYNHCLKGFVLVANTFPNVYAAMFESTLRAILTNLPDFNSHEKNFELLIDTVMRFSDQLNEKPHLAEEMVRIIRPDIKKNGLGNMRELKKRMKLTMALVKMAKSQKMLEETNQMISEMSIELEENGGKWSSASLITIVCDVFNELLILGKDDVKLQKGVEESLCNVLKDLNLSNQSTMEKQAFFNSLAKIVKQLPAESQVKTRVHQIVFNTETGLFTPKNRDNRMFGHNMIYKDLINLVSVLLTPTSLNHLQATYTDLRKIMIDSMSRLKQSEDTPYSDNIRWNESILLLFFSSLQSISCAKSSLIVMMGIRPSIFEFFSSELPLTEYWLASNHPEVYHLFITIFVGHLKAHDFYIVQSDYIVRGDSIGQSIGQTKRDYARKQVVALQKIINNFGDKLWKKTRLMISSWLHSLIATACEHQIGSDSFSQREWVRLRNTVIHQSVLTWNNECVNQALTILSTATKWSELTSDIHRDIADKTKKAKWKEATTIWESGDCNTYIRQSMSTVYQMSQERQQKTITSTSFGAEEFIIITNFLLKQATPTTFKKGQNSWMDEVLETFTQGCRTLEKPDSYVPETFIEKWDWIINQTANFCIVNKMKTPLGKPMQTFAAFENEIKRLAKEVIVRKNSDKKLNKSSTEDPNQSPPLKYSVQWLRVHLLLKLIVVLEKLMNSAIHGGSSVFNLTEIPVSSRQFFTVNAASCEVWLNRVYYPALLVAYFNGYYGLVIRFGSNALSHFARQKDGDNDKKIVNGVCTASLMSLSMAVLGEPMEIVGLRRKVREEFGTDMGQSLMEALGEMANARYETALVALEAVLVTDAATNETLKMIIQLAMVDILNRIRLPQATDYYKVVLFGEESNDSTITEDFRSVELLTKFEKLNNTVNEKRQVVDWSARERFQFVESAFSQTMRRTELLDIQKDFSAMGALALSADSSCKLYSDISSTSLIIANLVNKMTGVSQWKNKLTDTEIFDRNEEGNDGDKLAICRKLMHWGRHTKSNRGQSCAAHSEIIRLSRKTSNCELAFFHINSAIRGEKLAAWQRLEVERQRLKLVKTQNLDVRIREMNEVFGSLAEVFTTSCQLKSDFQMVDGMIKEKMISEGYNEDIAKREEHMSRASIQLADFFQSLPELENVLAPNLFPTIIWSELQRRSDSLSAGYHGIVGSLFHLASEMCPSLAKAHLKMARWAYEIAKIKNFPAENLSFYKFGKDETENEELLKSLEATSLVNLEKLVRAAISDDLRANNILAPNSHFMHIWKMVRDHRTKFLSIAVTSYFQFIQNMSGDCDNLPYSKKEETTLATLRILELLVKHGDVLIDVINDGLNKTNVHIWKEILPQLFARLSHPSEHIRKTLVDLISKICTAAPHAVVFQVVSGAASSSTDGEELEEQQNDDRNRVRACCEKLETNMSQSYPNLVKDVRQFVAELERINLLNEEKWSVVMGTMEHEMEKRLSLIRTENAKTESALHLTASVKNDIIVKRTQLLTRQIFDVLDELYQQTVIEPPKSKNEEEFVTAFAEVLTNAFQESRISRTTSPEKSWIPFKNLIANFVHRNSKKGMQTFETEDISPYLASLSNSCVPMPGQESVEFDRVVSISRVARQVTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALKQATKKNGETVPEIERPSNMYHNMIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPLVDWTSHEHTATSGVSLALQLAVYGSNWKTKAKERLTDAMELLNLRMSEVQTLWLANRDDLLHWMKQVTECLLIENSMLGANAIYAQQRVKAGTELREAVTRHHALAKELRPLIRVIGKEREEFADYLKFYKQALFDPLLKGHSALRNELDIDTCVYNFNIVMQNIDNVFGALVNLSFTPIETITSRTSQQEFKPPPGLENVWVVKQDQQENSQAREVVRRVERRLNGWLDGSAGPDRKLSPREEADILIAEATSTPNLSQMYEGWTAWV
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MERAFKMGADLVELRVDLIWDELPSADSLSSLISGFNDRVIITYRSRAHGGKGESQDVEWLRSVSKICGYVDVEYENSRIGIGNAIFSWHDPSGTPSYEELLSISEELLSLGGIAKIVTYARDEREAYRVLSLYKLEHRRRLVAFSMGERGSFSRRLSAALGSPLIYSYLGKAAAEGQISLDEAVLLKELLS
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MGRTLNREPTHSRNANDRQLRAVKREQMSRNRVGSGRDDSTQQHELDRRALRSKYLALHNKINDERDVLTRVDSEKFNSMIKEVEDLHQHVQKPREQVADAEALLGLTSTLVSSVKSQSNEGITAADFVSCVLSQFGQSNRTLDEENLSSLIKWKEIGLAVSPIFRKCNGFNTMVGPMNTELKQRRIPVRNNRKRARPTERSQPEEVDNTGAEEKKDTDNNMSTMFEILRRKKRVPLENLILNRRSFAQTVENLFALSFLVKDGRVQITMDESGAHFVLPRNAPAANSVMSGEVTFRHFVFRFDFKDWQLMMNVVSNGDELMPDRKSLATSESEPATNNIQVQGTLNRTPIRKFSRNRGLIVQEDSVVEESPEIEATKAIGSFRCKRKLT
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGAIGLRLSLLAFRSTRIQPFRPSPSFHQIPPSYFLAHQLRSASSKPPSDPKTLRSSTEPASPTSKKGTKNKLSNPESNRSQTTIKAVPENHAEKSKSEPQESSPSGQINSKDSPRSSPDESSSNHPELPTETSSSTLAAEMLQVTSDLPPPPPEGRTGAKSKLDGKRPLSSTDQRRQLVTRLLGSLILTLSGIWAWSQTRDWDNEVERRMLGKGEDGTRLSRLQARLFDLFDYFNKPAWNPLLPAPLPEPHGRPYTLLVDLDDLLVHSSWDREHGWRTAKRPGVDYFLSYLSQLYEIIIFTTQPAYTAAPICEKLDPYGYCTPYKLFKESCRTKGLIKPQLIKDLDYLGRDLRKVVYVETDPRLVQLHPTNGFLIPKWNGDPNDTSLVDLIPLLEAIVFNAVDDVRDVARAYQGRDPIRAYAESEARQKKELLLKWHEEQEKRKSRFHVDLRQLFGLSSGNKDESPQLLVEKDRARAQQAYVEEQKYWKENEGTFKKLMEEDRERQMAEMKGSLLSFLTGQVGPPPPSSSSSSTTTTESSPENSHNQIERSSSPSS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
Sequence:
MYYGFDVGGTKIEFGAFNEQLERVATERVATPTDDYAKLVETIAGLVHKYDAQFGVEGTVGLGIPGMEDADNGCVLTVNVPAAKGKPLRADLETKLGRAVKVENDANCFALSEAWDDELKEAASVMGLILGTGFGGGLVYEGKVFSGRNHVAGEIGHMRLPIDAWFHLGEKAPLLGCGCGNKGCMDNYLSGRGFELLYEHYYGEKKKAIDIITAQKEGESKAVEHVERFMELLAICFANIFTANDPHVVVLGGGLSNYDLIYEEMPKRVPKHLLSVAKCPKIVKAKHGDSGGVRGAAFLNIK
The following text describes a protein:
Function:
Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
Subcellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network.
Sequence:
MLSSLFTFLPSKVMRGSHGQMKCPPLHFQPGDQPGMEGAVRRGQGPSRFAVSALGWRARQGCLGDREVGGQWTLLLAQECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLEGPPEAMGRGRDWNVDLIPKFLMANGEGDKGGVMAGVGVGLWGQLAGGHTPETGPPDQLELLQGAALTVAFPAPAAGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQSTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYVPDRVRKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETAEPEKEVEPALELLEPIDQKFVAISDLYEPVDDGSESQVFCSCSYDATTHFETTCNDIKDIYKRMVGSAFDFENMKRKQNDVFGEADQ
The following text describes a protein:
Function:
During the asexual blood stage, plays an essential role in the recruitment and/or formation of EMP1-containing vesicles at the Maurer's clefts and their subsequent transfer to the host erythrocyte cell membrane.
Subcellular Localization:
Host cytoplasm. Vesicle. Membrane; Single-pass membrane protein. Note=In the host erythrocyte cytoplasm, localizes to Maurer's clefts, chaperone-containing structures known as J-dots, and EMP1-containing electron dense vesicles (EDVs).
Domain:
The P.falciparum Export Element (PEXEL) motif, also known as the vacuolar transport signal (VTS), is a pentameric sequence (RxLxE/Q/D) required for the translocation of proteins across the parasitophorous vacuole membrane (Probable). In the endoplasmic reticulum, the motif is cleaved after the leucine residue and the N-terminus is N-acetylated (By similarity).
Sequence:
MAKDSQKNLNVSNNNNVQCTMGRSSQNINKSDSKGKIKRCTYAYKILLCTIFIWICQCFYNKSYYVYKKDGRRNKGKKILGIRINKSLAEMDHTKYHPEYYDEVQENYDPYYGVNQYSDECESYKSEDDDSEEEYYNSTPRVTVLEPQTENSEDEENYEKTIVDELNELPNDKKALILSYIRNGNDNNMQLLPYANNNKQNTQENISRNKEFFRHFVDFIKGYKLFDSPVLNALLPFIFIAFVYCTITMLVGNVRYIIALYILAKILKMHYDYKHKENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKKSKKN
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MGSTKDLTGSFQVSLNGGEVMADPVEVADGSNLSSHYLKGGVSCEKKSDSSPFNVNSEVKHLDGSGPCQPQEMVNSLGETSEVKDKTSEQTDQTSAVHVEESSDIVQRDTVVTAKVTKAAQENSRLSAAPVKDQTKNECSPPHPSQTSSKAVDDSNVTNHAPTCSIKKEVIEEIKSSSHSSDKETDSLNECGNPRGDYAVLSDGSTVITNSKAIRNEEQSLKKAIDPNISLPEKDSNYPAHSDGQKQNTEASTKFQINVQETQETKQIKVQSPQTKASQGVTVKLVIHKDNTMQPEPKSAGNSCSKTKGNEDKRTGELNVLPNSGVKESGSTLKPSSALSPSQHEEKNQLKQSGGSKIKARCLSESDAKLKVHDNVFRDNKGQAVTSPTYISPHTLSASTQHAEIQVSLEALCKSAATSPMTPPEGCAAFFFPYSTGKGAPPGVEEVKIATKDAELQVGHQVESRSVATAPMSPLSLTAEASYPEIQIKGVTEDDQPEPVREVRWDEKGMTWEVYGAAMEVEVLGMAIQKHLEKQIEEHGKPPPLLPLAATPNTAVNRMGSLKGPVKALPEKRQHRNPFRVVLQNIRRPRCCARASTIE
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSLRRTILDLHRQTQRATLSKSLPFSMSHISSASATAAVRNPLGRDLSSIPFAQAQKLKPDSTNLVTDRSISSSIGQSELNKAAKFSRQSSSRGYTNGSFLRKIPVVFHIHEGMEEILADYVHQEMTRNLIVMSLGLFQIIVLKDIILFLL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGRAQGARWMARRVIGLTGGIATGKSTVGRLLAGWGIPVIDADLLAREAVAPGSAALAEIVQHYGSTMLTNAGALDRSALARIIFSDPQERRWVESRIHPSVRAAMQAAVEREPGTICLMIPLLFEAGMTDLVTEIWVVSCKPERQHARLKERDGLDDQAIAARIASQWPLTEKVRHADVVLDNDGDFAHLKIQVERALDQASI
The following text describes a protein:
Function:
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia.
Subcellular Localization:
Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAISPRSDATFSSQKSTRSESPRTKKFPLTEEEIFYMNCRAAYLTVFKSSLENIISKDQLYLALQHAGRNPSQKTINKYWTPQTAKLNFDDFCIILRKEKPTSKAELLKSFKQLDVNDDGCILHTDLYKFLTKRGEKMTREEVNAIINLADVNDDGKFDYIKFCKLYMTTNEQCLKTTLEKLEVDSKLMRHQFGNHIKGSPERDPSPVPKPSPKITRKTDPETFLNKGDTRSSLLSATRKFKTSVSFTVTMGPNGNRNSKLTEPNLIKDWQHMQSKGCFFLEEDGEIISHQYRMQIAQRSMVYLTIKPLNLSQVEGKPSPWLSVDTALYILKENESQANLQLVCFTELRNREVFGWTGELGPGIYWLIPSTTGCRLRKKIKPVTDEAQLVYRDETGELFLTKEFKSTLSDIFEVIDLDGNGLLSLEEYNFFELRTSGEKCDEDAWAVCRENFDTKRNELTRQGFMDLNLMEANDREGDPCDLWVTLHSMGYNKALELTEACPFVIDIYAEKCKPKIKAVHMEACSGQLEKAICKSVLSNGDAKVMDGYENIIVHTYSCDTWITSVIENKSDEKVIIHINNELSKNCINNRGLNIFAVEVGPKSTMVCQHVMPLNERQEWIYYCIYSLIS
The following text describes a protein:
Function:
Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown.
Sequence:
MRVLIKNGTVVNADGQAKQDLLIESGIVRQLGNNISPQLPYEEIDATGCYVFPGGVDVHTHFNIDVGIARSCDDFFTGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMIVEEGLSSFKLYLTYQYKLNDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLYIVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWCGISDGAIDVVATDHCTFSMAQRLQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRITPERFVELTSAMPARLFGLWPQKGLLAPGSDGDVVIIDPRQSQQIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MDMSAIAARLGLSGSRPVVRKAAELRRLCDINFDSSVLGIGEVCKAIICLEIAATKFQVIFDRSEAVRMSGMSEKAFIRSFNALQNGLGVKTTLDVRELGIQFGCVRLIPFVQKGLALYKERFLAALPPSRRSSTDFGRPVFTAAAFYLCAKRHKLKVDKLKLIELCGTSSSEFTTVSTSMGDLCFDVFGIAKEKKDPTSIKGNRELLDVLPSKRKHEDDSDHSDESSGDDNDDELDLPTHKRHKKMEKQAYNQWKSSVISTNKQAKPDPTKPRKQAQLNFKKKLPDAALEVPPPAS
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MEERGDMKLLGTKESLFTQRIVWALKLKGIDYAFIEQDLSSRNSPLFVELNPVYKKVPVIVHAGKSLCESLVILEYIEETWPYNPLFPIDPFQRASARFWARFIDGEFYEAAKKAFFSSGEAKAEGVESVEEGLRLLEGQIIGKKFFGGEKIGYLHIVAGWISYWFQYIQEVGEFKAMDSRKYPCLHAWINNFIQVPIIQQSLAKPDDVKAVFGGFKDAAALAGAN