lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAAAAEATTTVVDDAELREAQRDYLDFLDDEEDQGVYQGRVRELIGDNRNRLIVNIDDLRRKNRKRAHRLLNNAFEELVAFQRALRDLVASVDATYAKQYEEFYVGLEGSFGAKHVSPRTLTSCLLSCIVCVEGIVTKCSLVRPKVVRSVHYCPATKKTVERRYADLTSLVAFPSGSVYPTKDEENNPLETEYGLSVYRDHQTVTIQEMPEKAPAGQLPRSVDVVLDDDLVDKAKPGDRVQVVGTYRCLPGKRGGYTSGTFRTVLVACNVKQMTKDVQPSFSADDVAKIKKFSKTHSKDIFEQLARSLAPSIHGHDYVKKAILCMLLGGVEKVLDNGSRIRGDINVLLIGDPSVAKSQLLRYVLCTAPRAVPTTGRGSSGVGLTAAVTTDQETGERRLEAGATVLADRGVVCIDEFDKMSDADRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVVLDRMDPERDREISDHVLRMHRYRAPGERDGHAMPLGGAVDVPATDDPDFAREDGRRVQVYEKHDDLLHGPGRRREKTVSAAFMRKYIHVAKIVKPVLTPEAAGYIADEYSRLRGQDSPSDDVARTSPVTARTLETLIRLSAAHAKARMSKTVELRDAESAVELVQYAYFKKVLEKEKKRKKNPEGDEEEEEEEEEERSRERPESGRKRRKTRSAEAREGGSYDPYDFSDTEGEMPQVHTPKAPEPEEPGEAEKTELPEPRLKAFKAALLEAFREARAQSVAVASLAASVNRDNPEPFAPAEVRAALDRMQDDNRVMVSDDVVFLI
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
Sequence:
MTTTTDLVSYEDALASYDPVMGLEVHVELGTKTKMFCGCSTALGADPNTQTCPVCLGMPGALPAVNATGVESAIKIGLALNCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAFDGYLDVQLEDGETFRVQIERAHMEEDTGKSLHVGGATGRIHGASHSLLDYNRAGIPLIEIVTKPIEGAGERAPEVARAYVRELRELIRALGVSEARMEMGQMRCDVNLSLRPHGREKFGTRSETKNVNSLRSVERAARFEIQRHAAVLNDGGTIIQETRHFHEDTGSTTSGRVKEEAEDYRYFPEPDLVPVAPSRQWVEEIRSGLPELPLVRRNRLREEWGISGNDMQSILNAGALDPIVATIDAGADAASARKWWMGELARSANESGKALDELAITPVQVARVAELVTKGELNDKLARQVILGVLAGEGTPDEVVDKRGLKVVSDEGALTTAVDEAIAGNPGVADKIRGGKVAAAGALVGAVMKATRGQADAARVKELILEKLGVAEG
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKATKYSVGILRFMSFYARFLSLVCFRLRKQKDNNVWLEEIWSNRSRWKWISVTLRIVPLCIYAFTYAEWISNRMLITEKFLHSCSLVVSIPCYLSIIHLKICHGPEVTKLVNQYLHIFRLGTLDIRRRSQFGGGRELFLLILSVCCQIHEYVFILVIASRLCGFQHIIWWVSYTYVFIICNSIMCFGFIWHLSLGVLYAELNDNLRFESGFQTAFLRKQQRIRVQKSMALFKEISSVVTSLQDIFNVHLFLSALLTLLQVLVVWYKMIIDLGFSDFRIWSFSLKNLIQTLLPVLAIQEAANQFKQTRERALDIFLVGKSKHWMKSVEIFVTHLNLSEFRVNLLGLFNVSNELFLIIVSAMFCYLVFVTQCVIVYRRRYVI
The following text describes a protein:
Function:
May play a role in transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADTEGTSSSIPTSTNSSRHRASRGRGGRFRQAPRQVGANTADNLDAAPLMNPRGGHRGGSGNKRGRGQKEATSASRLQMQPEANFTFNPNAATFNPAQSVLFDPSVPPPTIGASTHSNQNSRQQEPSQNRRRRGGQQNTQRRQLEIQEQRGDSHPQNQSRQNNRNQLNVDRIANQQNKSVQNPSRNPGNSRRGQGARRREQKEEPLTEEETKILADKPLREGLVYLLENNKYECAICYTRITTRQGVWSCKTCYHIFHISTGCITDWARSSRDKEGANTWRCPTCQTENETMPYNYYCFCGRMRNPNFRVGEVPHSCGETCGGARKFGCPHPCTELCHPGPCIECKLFTTKSCNCGKTKKSVRCGSDQEVMCETVCGKQLSCGQHNCERICHSGDCGECTVILEQDCFCGKTPKEVSCNPCAHEKYSCGSECDGMFSCGIHHCTKKCHDKECGECETGANRIRTCPCGRNTLQSLGVTRKKCTDMVPTCDSVCDKWLTCGTPGKNHHCREKCHEGPCPPCNLNTSVICRCGTSKGVIPCDEYLQIMKTTGEYLCTKRCRKKKSCGMHKCQEVCCIQDEHFCLQMCNKRLSCGIHTCENVCHAGQCRPCLQASFDEQFCHCGHTVRMPPIPCGARLPVCSQPCVRPHSCDHSVSHKCHGEQNCPPCTQLTEKMCYGGHRVRKNIPCHIDSVSCGVVCKKPLKCGVHVCQRTCHGEECEKEGEKCTKKCETIRELCEHPCALPCHEDSPCEPSPCKASVRISCECGRIKKDAPCCEVDKMILSKLEKEEEEKSESDGEEKVVKEGILKRSTSFSQLNCMKCDDECKKLERNRKVAEALEVDTDEYGMNKLAPTISFPCYLKEMVRTNIDFVKSVEKILIDLVIQILSGEAYHDTFRAHLPAMSIEKRRFVHEYANFFNIASESVDSPPKRSIVLTAVRGKSHQPLVLISDLVNYKGALKTPGPAVIRKDIMDQALSKKEETEGLMKPLRCTEKMVVRREARPMKEITAPIPLKQQNQFALLGSDVDSDDEESNVPTTSNLVSSPPKDWWKDEEEGWQKVQQKEYVVEVERDMTEDEIEAAKKLDEGPTWEDQCDEDAPATETSSAIESPAKEEPVAELLE
The following text describes a protein:
Function:
Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator.
Sequence:
MAYYSIGDVAERCGINPVTLRAWQRRYGLLKPQRSEGGHRLFDEEDIQRIEEIKRWISNGVPVGKVKALLETTSQDTEDDWSRLQEEMMSILRMANPAKLRARIISLGREYPVDQLINHVYLPVRQRLVLDHNTSRIMSSMFDGALIEYAATSLFEMRRKPGKEAILMAWNVEERARLWLEAWRLSLSGWHISVLADPIESPRPELFPTQTLIVWTGMAPTRRQNELLQHWGEQGYKVIFHAP
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTTTTPSPKSSGSALAHPHKTILKSFLLWKLFLLLIAVGSTLVNDRAYDTSADLLLVGNAEPLSVNDDGNGDGVVELLSNFGKRLVTRFTSWDAIYFVSAAKRGYVYEQEWAFGTGLVVCVRGVLKALQTLGLPLSLATSPTALAEATTALLVSNASHLLASLVLYHLTLLLPLSGSNSSPQKRRKLALLTSLLHIFSPAGLFLSAPYAESSCALFSFLGWWFYAQSCLSDQDGTTAVSGNVERGAKGIFTVKGDVHLLLAGLSFGLATLFRSNGILNGLPFAWEVLSILSGFVITTSGGRERGRVPLFKTLRRLIALGLGGIFVAAGSIVPQTVAWLRYCPSGSLWLLNKFLLSGSQVEVSETSGGSGSARGYGSSGVGAGVNSGAGGGLEELVAQEEAREWCAAVVPSIYTFVQKHYWNVGFLRYWTLPNIPLFLLAAPMLAILVKSALDQLSQQSSTVTTTINSDAKSTSSASPDTPSSGSVTPSNPESPTTAQQQRMQILIGSAAAEQVLLAVLAVSTYHVQIITRISSGYPLWYWWLAQLLIGDGDMQQQQQQQQQQKKKQLGKGIVVFMVMYAAIQGVLFTSFLPPA
The following text describes a protein:
Function:
Insertion mutation in SMT4 confers temperature and benomyl sensitivity; high copy suppressor of a temperature sensitive mutation in MIF2.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Sequence:
MSARKRKFNSLKPLDTLNSSRASSPRSSASLPPKRYNTFRKDPKIVDHLNNASTKDFLPVLSMNSESKRQIELSDNDVDNNDEGEGVNSGCSDQDFEPLQSSPLKRHSSLKSTSNGLLFQMSNNLGNGSPEPAVASTSPNGSIISTKLNLNGQFSCVDSKTLRIYRHKAPCIMTFVSDHNHPKFSLYFQQSVIYNSQVNLLDDVELIILDKKNSFMAIILKDLKKVKMILDVNNSSININTNILIWSTASSASNKKIKSIKRFLLMSYSSSIKVEILDHKEQILERLKHLIHPISSSSPSLNMERAINSTKNAFDSLRLKKTKLSTNDDESPQIHTHFLSNKPHGLQSLTKRTRIASLGKKEHSISVPKSNISPSDFYNTNGTETLQSHAVSQLRRSNRFKDVSDPANSNSNSEFDDATTEFETPELFKPSLCYKFNDGSSYTITNQDFKCLFNKDWVNDSILDFFTKFYIESSIEKSIIKREQVHLMSSFFYTKLISNPADYYSNVKKWVNNTDLFSKKYVVIPINISYHWFSCIITNLDAILDFHQNKDKNDAINSDEISINNPLVNILTFDSLRQTHSREIDPIKEFLISYALDKYSIQLDKTQIKMKTCPVPQQPNMSDCGVHVILNIRKFFENPVETIDVWKNSKIKSKHFTAKMINKYFDKNERNSARKNLRHTLKLLQLNYISYLKKENLYEEVMQMEEKKSTNINNNENYDDDDEEIQIIENIDQSSKDNNAQLTSEPPCSRSSSISTTEREPTELHNSVVRQPTGEIITDNEDPVRAASPETASVSPPIRHNILKSSSPFISESANETEQEEFTSPYFGRPSLKTRAKQFEGVSSPIKNDQALSSTHDIMMPSPKPKRIYPSKKIPQLSSHVQSLSTDSMERQSSPNNTNIVISDTEQDSRLGVNSESKNTSGIVNRDDSDVNLIGSSLPNVAEKNHDNTQESNGNNDSLGKILQNVDKELNEKLVDIDDVAFSSPTRGIPRTSATSKGSNAQLLSNYGDENNQSQDSVWDEGRDNPILLEDEDP
The following text describes a protein:
Function:
Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs. May regulate the activity of some transporters.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.
Sequence:
MHPKIVKLHEFADTQQEELIHAAVASLKLGHVIALPTDTIYGIAALTQSCNAVQKLYEIKGRHQEKPVAIAVGNIEDVKRWGKVTVSDDILTDLLPGPVTLVFERTPELNPSLNPGTTLIGIRIPNHHFVRKLAKACAEPIALTSANQSSAMSSLKVEEFKSLWPHLDLVVDGGPVGDSPECRQGSTVINLSVPGQFSIIREGSAYQQTLDVLEAKYGLTNTER
The following text describes a protein:
Function:
Mediates bacterial resistance to streptomycin. Adenylates streptomycin on the O-6 residue. Adenylates streptidine on the O-6 residue. Does not act on spectinomycin, neomycin-B or kanamycin. Specific for ATP and GTP nucleotides incorporating a purine ring. No reaction with CTP or UTP.
Miscellaneous:
MISCELLANEOUS: Although this enzyme can be purified from B.subtilis, the bacteria is sensitive to streptomycin in vivo.
Subcellular Localization:
Cytoplasm.
Sequence:
MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYDISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDLTLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFWMVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRYLSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYTEGIYCSVK
The following text describes a protein:
Function:
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans. Acts as a procoagulant by enhancing the generation of activated factor X/F10 in the presence of tissue factor/TF and activated factor VII/F7. Independent of its enzymatic activity, increases cell adhesion to the extracellular matrix (ECM). Enhances AKT1/PKB phosphorylation, possibly via interaction with a lipid raft-resident receptor. Plays a role in the regulation of osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis (By similarity).
Subcellular Localization:
Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity).
Sequence:
MLACRKPGLRPPLLLLLPLLGPLGPCSPGTPAAAAPADDAAELEFFTERPLHLVSPAFLSFTIDANLATDPRFFTFLGSSKLRTLARGLAPAYLRFGGNKGDFLIFDPKKEPAFEERSYWLSQSNQDICKSGSIPSDVEEKLRLEWPFQEQVLLREQYQKKFTNSTYSRSSVDMLYTFASCSGLNLIFGVNALLRTTDMHWDSSNAQLLLDYCSSKNYNISWELGNEPNSFQRKAGIFINGRQLGEDFIEFRKLLGKSAFKNAKLYGPDIGQPRRNTVKMLKSFLKAGGEVIDSVTWHHYYVNGRIATKEDFLNPDILDTFISSVQKTLRIVEKIRPLKKVWLGETSSAFGGGAPFLSNTFAAGFMWLDKLGLSARMGIEVVMRQVLFGAGNYHLVDGNFEPLPDYWLSLLFKKLVGNKVLMASVKGPDRSKFRVYLHCTNTKHPRYKEGDLTLYALNLHNVTKHLELPHHLFNKQVDKYLIKPSGTDGLLSKSVQLNGQILKMVDEQTLPALTEKPLHPGSSLGMPPFSYGFFVIRNAKVAACI
The following text describes a protein:
Function:
Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity; Together with AhpC, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system.
Sequence:
MSIEKLKAALPEYAKDIKLNLSSITRSSVLDQEQLWGTLLASAAATRNPQVLADIGAEATDHLSAAARHAALGAAAIMGMNNVFYRGRGFLEGRYDDLRPGLRMNIIANPGIPKANFELWSFAVSAINGCSHCLVAHEHTLRTVGVDREAIFEALKAAAIVSGVAQALATIEALSPS
The following text describes a protein:
Function:
Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.
Miscellaneous:
MISCELLANEOUS: Present with 3460 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Trans-Golgi network location requires interaction with CHS5 and with myristoylated GTP-bound ARF1 for the recruitment to the membranes.
Sequence:
MLSQTSIPEVKEDVIGYALHQRRARVGQFQDLGPPDLITLIKSLPSSSSTTTATASANDNGATSNINGQDPTTIVTELHSHDKLKGQIGTFFYCMGIDTSDPTSITIFAKKITDLFLDTPQIWFGKKKHFHVSKISISSWNAFRKYDVNIIVHIPGTVQTYIINSDGEQSQLPSVAEASSGRNSQDLNVNMIWAETFMSGIVRDIMIMKDNRADGESQNLVETLIFNPFTSGELEDVANNFIKLFPLVYEKGVYLDAPTHVLNPSLTNNYLVETLVEIVRLTKSLEACRKMLKKLIEIHPEAVIILIRVYFACDLEIDAVDLINEQLNSPSSFLADDSKTSHIQLIFKSELLSIQSEFLLDVKRDYKLAKEVAMEAVNCAPNEFKTWYLLTRIYIKLNDMSNALLSLNACPMSQVKEKYVLRRIAPITSDENLHLPLPLDASIEEISSLNPMDVQLEQKSADPNLVNLSASSLKSTFQLAYKLLTEIVQITGWEQLLKYRSKIFVMEDEYQGSTSSIDEAEVRGNDISKMRSKRLCERWLDNLFMLLYEDLKTYTDWQSEQLYFDAQNSKYHKLTVEWELFGLCAKRLGHLPEAAKAFQIGLSQRFSPVCAKNLLQFYIDEHKRIRRDSVSANSELTSSQILSSINDIDSSIIDLVVKICCWNHRWYIEFSIILIDALSVAVQDMGITKVHNEIASRFSDPVAQLIDDNILNFLKNFTNDTFDN
The following text describes a protein:
Function:
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVVRPEFRPAPGLDTDAMASRQRDIAAVADFADDHGLTPERIGLDEPPGEQAALGGATTSGEAAPVVVGVDQAFRDDEVSVSAAVAIRDGAVIERAAGNAPLDVPYVPGLLAFREGSAVIDALSSLSVEPDLLVVDGSGRIHYRQAGLATHVGVLFDVPAVGVAKSLLCGTPAAALADPLPAGTRVAIEADDSMDAPDGAVVGYALQSRQYPTPETRHINPLYVSPGHRVSAGTAADLVEATCTQYKLPAPTRLADQYAADLT
The following text describes a protein:
Function:
Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1.
Subcellular Localization:
Cytoplasm, Stress granule. Cytoplasm, cytosol.
Sequence:
MPALSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPAILDSLDLTEEERRVLIDNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKTED
The following text describes a protein:
Function:
Plays a crucial role in virion assembly and budding. Forms a shell at the inner face of the plasma membrane and concentrates the HN and F glycoproteins. Acts as a negative regulator for transcription and replication by sticking to the nucleocapsid. This effect might be regulated by the cytoplasmic interaction with tubulin that dissociates the M protein from the nucleocapsid (By similarity).
Subcellular Localization:
Virion. Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=During bud formation, associates at the inner side of the plasma membrane of infected cells.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. The matrix protein contains one L domain: a YLDL motif (By similarity).
Sequence:
MADIYRFPKFSYEDNGTVEPLPLRTGPDKKAIPHIRIVKVGDPPKHGVRYLDLLLLGFFETPKQTASLGSVSDLTEHTGYSICGSGSLPIGVAKYHGSDQELLKACTDLRITVRRTVRAGEMIVYMVDSIGAPLLPWSGRLRQGMIFNANKVALAPQCLPVDKDIRFRVVFVNGTSLGAITIAKIPKTLADLALPNSISVNLLVTLKTGISTEQKGVLPVLDDQGEKKLNFMVHLGLIRRKVGKIYSVEYCKSKIERMRLIFSLGLIGGISFHVQVTGTLSKTFMGQLAWKRAVCFPLMDVNPHMNLVIWAASVEITDVDAVFQPAIPRDFRYYPNVVAKNIGRIRKL
The following text describes a protein:
Function:
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MASVGPWGRCPAWRQLRSPALRWQKETWRKAGTRWQRTQRMGTVMERSNAEQQENIVALQQGAAEPQDTTEPQDMGACRQELEEGQRAPGTAGSPAGEAAVTPTGSTERRGNDAEEEEEEEEEEEEDEEDTEEDEVQVIEVPKGSGAVPQQQEGGTELFPPGSPTCNAPAERAGEQPGLGKKNDISRHSYSRYNTISYRKIRKGNTKQRIDEFESMMHL
The following text describes a protein:
Function:
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRGGRDSDHNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW
The following text describes a protein:
Function:
Minus-end-directed microtubule-based motor protein. Has ATPase activity. Required for normal chromosomal segregation in meiosis in females, and in early mitotic divisions of the embryo.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MESRLPKPSGLKKPQMPIKTVLPTDRIRAGLGGGAAGAGAFNVNANQTYCGNLLPPLSRDLNNLPQVLERRGGGARAASPEPMKLGHRAKLRRSRSACDINELRGNKRTAAAPSLPSIPSKVSRLGGALTVSSQRLVRPAAPSSITATAVKRPPVTRPAPRAAGGAAAKKPAGTGAAASSGAAAAAPKRIAPYDFKARFHDLLEKHKVLKTKYEKQTEDMGELESMPQQLEETQNKLIETESSLKNTQSDNECLQRQVKQHTAKIETITSTLGRTKEELSELQAIHEKVKTEHAALSTEVVHLRQRTEELLRCNEQQAAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQSIDAQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSESPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRNRYLNNSVANSSTQSNNSGSFDK
The following text describes a protein:
Function:
Antibacterial peptide active against Gram-positive and Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
ATCDALSFSSKWLTVNHSACAIHCLTKGYKGGRCVNTICNCRN
The following text describes a protein:
Function:
Microtubule-associated protein involved in the regulation of anisotropic petal and cotyledons growth and shape by affecting cortical microtubule organization. Prevents cortical microtubules organization into parallel arrays oriented perpendicular to the axis of cell elongation thus limiting anisotropic cell growth in the late phases of petal development. Cooperatively with ANGUSTIFOLIA (AN), negatively regulates cortical microtubules (CMTs) organization in response to mechanical stress and modulates pavement cells morphogenesis leading to puzzle shape, probably in an AAA1/KTN1-dependent manner.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with cortical microtubules and binds directly to microtubules. In young pavement cells, observed as granules in the cytosol and at the cell periphery. Formation to granules on microtubules is promoted by mechanical perturbations.
Sequence:
MVAGKVRVTMGFHKSPSTKKTKDMPSPLPLPPPPPPPLKPPSSGSATTKPPINPSKPGFTRSFGVYFPRASAQVHATAAAASHNGVVSELRRQVEELREREALLKTENLEVKLLRESVSVIPLLESQIADKNGEIDELRKETARLAEDNERLRREFDRSEEMRRECETREKEMEAEIVELRKLVSSESDDHALSVSQRFQGLMDVSAKSNLIRSLKRVGSLRNLPEPITNQENTNKSISSSGDADGDIYRKDEIESYSRSSNSEELTESSSLSTVRSRVPRVPKPPPKRSISLGDSTENRADPPPQKSIPPPPPPPPPPLLQQPPPPPSVSKAPPPPPPPPPPKSLSIASAKVRRVPEVVEFYHSLMRRDSTNSRRDSTGGGNAAAEAILANSNARDMIGEIENRSVYLLAIKTDVETQGDFIRFLIKEVGNAAFSDIEDVVPFVKWLDDELSYLVDERAVLKHFEWPEQKADALREAAFCYFDLKKLISEASRFREDPRQSSSSALKKMQALFEKLEHGVYSLSRMRESAATKFKSFQIPVDWMLETGITSQIKLASVKLAMKYMKRVSAELEAIEGGGPEEEELIVQGVRFAFRVHQFAGGFDAETMKAFEELRDKARSCHVQCQSQTHQHKLCFRSTPC
The following text describes a protein:
Function:
Plays a major role in the promotion of the transition of the vegetative meristem to reproductive development. Required for RNA-mediated chromatin silencing of a range of loci in the genome. Cotranscriptionally recognizes aberrant RNA and marks it for silencing. Controls alternative cleavage and polyadenylation on pre-mRNAs and antisense RNAs. Regulates flowering time, seed size and cell volume, probably via the modulation of cell size.
Subcellular Localization:
Nucleus.
Sequence:
MHRGSDRSADPSGPAGAARSGGDGRFARGPSRWSGGGGGSPPPHRSSRGGSSDGGGGGGGGGGGRFHPYRAPSEYVVGGGGTGGYRGGGGDFDETAGGARSRYGGGGGGGRGDYSDHDNKSGYVKLFVGSVPRTANEDDVRPLFEDHGDVLEVALIRDRKTGEQQGCCFVKYATSEEAERAIRALHNQCTIPGAMGPVQVRYADGEKERHGSIEHKLFVASLNKQATAKEIEEIFAPFGHVEDVYIMKDGMRQSRGCGFVKFSSKEPALAAMNSLSGTYIMRGCEQPLIVRFADPKRPRPGESRGGPAFGGPGVSSRSDAALVIRPTANLDEQIGRHMPPDTWRPSSPSSMAPHQFNNFGSDNSMGLMGGPVTSAADNVAFRPQLFHGNGSLSSQTAVPASSHMGINPSLSQGHHLGGPQIPPLQKPTGLQQNFPVQLQNAQQGQLHASQSLGPGSFGQNIPTMQLPGQLPVSQPLTQQNASACALQAPSAVQSNPMQSVPGQQQLPSNLTPQMLQQPVQQMLSQAPQLLLQQQQAAMQSSYQSSQQTIFQLQQQLQLMQQQQHQQQPNLNQQPHTQVPKQQGQPVQSNAPGAPAAMMTTNINAIPQQVNSPAVSLTCNWTEHTSPEGFKYYYNSITRESKWEKPEEYVLYEQQQQQQQHQKLILLQQHQQKLVAQQLQSPPQAQTIPSMQSMQHHPQSQQGHNQMQMKQQDLNYNQLQPTGTIDPSRIQQGIQAAQERSWKS