lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG) in the stationary phase of E.coli. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Other dicarboxylic acids (oxalate, malonate, succinate, adipate, and pimelate) are not substrates for this enzyme.
Sequence:
MNALTAVQNNAVDSGQDYSGFTLTPSAQSPRLLELTFTEQTTKQFLEQVAEWPVQALEYKSFLRFRVAKILDDLCANQLQPLLLKTLLNRAEGALLINAVGVDDVKQADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSLLLHLDDWEHLDNYFRHPLARRPMRFAAPPSKNVSKDVFHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSELSDAIETSKGILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYFAYASNHYQTHQ
The following text describes a protein:
Function:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Sequence:
MLLKELAELAMRIASTSSRRDKVSLVSDLIRRSDPEEAYKALLILTGRIFPPSDPRELNVSWATLWKVVSSLSGAEPTGVDAGELVKSIVERRGKRQTALLEEPLTVEEVYKILEAISEAEGPGSKGKREALLTIPFSRADPSEAWLLANAIVGETRLGLNEGLLIESIAQAYGLRKEDVERAVMVLGDPYEIVRRGGKLEFEPVLFRPLKPMLAQSSDSLRSAIEELGRCALEYKLDGVRVQVHKRGDEVRFFSRRMSDITKSLPDVSDQVRYGVRAGEAILEGELIAERDGRPLPFQILIRRFKRRQLDPRLIEEIPLKLYIFDLILLDGSSYLRKPYFERREKLEGLIEDPVSLVRSLITSDPDEGMDFMEEALREGHEGVIAKKLNSPYIPGVRGRYWLKVKETNSLDLVIVAAERGYGRRHRWYSDYYLAARDPESGEFLIVGKTFKGLTDEEFEWITQKLEELSIGKEGKLIRVRPRIVVEVSFNEIQRSPKYKSGFALRFARITRIRDDKSPEEADTIERVREIYEKQIRKFQL
The following text describes a protein:
Function:
Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.
Sequence:
MELSVLGQNNGGQHSAGGCSSSSCGSTHDQLSHLPENIRAKVQNHPCYSEEAHHYFARMHVAVAPACNIQCHYCNRKYDCANESRPGVVSEVLTPEQAVKKVKAVAAAIPQMSVLGIAGPGDPLANPKRTLDTFRMLSEQAPDMKLCVSTNGLALPECVEELAKHNIDHVTITINCVDPEIGAKIYPDLLEQQAHPRRQGRKILIEQQQKGLEMLVARGILVKVNSVMIPGVNDEHLKEVSKIVKAKGAFLHNVMPLIAEPEHGTFYGVMGQRSPEPEELQDLQDACAGDMNMMRHCRQCRADAVGMLGEDRGDEFTLDKIESMEIDYEAAMVKRAAIHAAIKEELDEKAAKKERLAGLSVASVQNGTSGRYRPVLMAVATSGGGLINQHFGHATEFLVYEASPSGVRFIGHRRVDQYCVGNDTCGEKESALAGSIRALKGCEAVLCSKIGFEPWSDLETAGIQPNGEHAMEPIEEAVMAVYREMIESGRLENDGALLQAKA
The following text describes a protein:
Function:
Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR). CrtD is involved in the desaturation reactions that form double bonds at C-3,4 of dihydroisopentenyldehydrorhodopin (DH-IDR) and C-3',4' of dihydrobisanhydrobacterioruberin (DH-BABR) to yield isopentenyld ehydrorhodopin (IDR) and bisanhydrobacterioruberin (BABR), respectively.
Sequence:
MSDLSGEDVTVVGGGIGGLSAACYLADAGADVSLLEKNEQLGGRASRLEVDGFRFDMGPSWYLMPDVFERFFAYFGKEPRDYYDLQRLDPHYRIFFKDGDQIDVTGDNDEMAQKFEEYEPGAGEAFEEYLSTSERHYETAMNKFVYQDRSELRDWVDLDVMTAAPVGLQLIGTMQSHVEDYFEHPKLQQIMQYTLVFLGGSPRTTPALYNMMSHVDFNLGVYYPDGGVGAVVDGLVELGEELGVTYETDAEVEEISRRKEGFLVETVHGDTTHPDEVVVNADYAHAERELLPDHERQYDDDYWDDKTYAPSAFLMYMGVEGDVEPLEHHTLVLPTDWDPHFDDIFDEPAWPDDPAYYLCVPSKTDDSVAPDGHSNLFVLVPIAPGLHDGDEIRQEYREKVLADIADNTGVDLRDRIVYEKQFAVSDFGERYNATEGTALGLAHTLRQTALLRPNNRSSAVDGLYFTGSFTTPGIGVPMCLISGEHTAEALIEDIA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
KCPQGWLRVDLNMDIEKCLTNSESLTRDPLPFLNGDAQVAGQLVDISSALYKLCNEKSKFSSKINALPELHTKQFDDEQIWQQIELFNNSNIITCTRQVHSCNRDAEISLIPVIKQNGDQDASDVSADEESQSDENMEENDPEETAEVDVDAESGVSMEKMEKTEVDDKFFSLRHMEKMLNKQETDNKQDDSDDEIDLFDDIPSTDEEEEFPDVESDQSEDHEVGKDAEVKKSARDVKYDDFFPGFGGNSNKDSNPEIEESFQDEEEEEVEVEVEKKTPHQAQQVKMKKQIKQLESRALEEKDWQMKGETTAEKRPVNSLLEEVLTFDKGERTAPEITDEQTRDVEEIIKQRIKDKSWDDVERKIKEVKNVHEFKKKVVLDSEKSKQSLQDIYEKEYIAKTSGAKEEEKEDPTHVELKSLMKNLFKKLDALSNFHFHASAPTPEIQVVTNLPTIAMEEVQPVSHTDASKLAPEEIHKNTEEKAEEEKTSTDRKRDRRKKKVRQKLRSKARESKLRLLADTNEKLQAVQAIQKLEQSAKMKGSQTTIIKGKKEEGLTSSKAFFSKLEIVNQKQMLKKKST
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MPPSKAEKRGLTLEKLASYDDVITDALVDKIYYWATIRKNRGTRFTASRGLQEEDIAGVIREQVIWDKDPVEAVQQLLDLPGLRKYMKGLRDEKDQDQFKRHLRRYVNIYMPDCPFEVTTTNRYTITDHEASITARRDINPREEIKYLTGVQVAMTEEQEKTLELARKDFSLVISSRKKTRSLFLGPARFANHDCDANARLSTKGYDGMQIVAVKPINEGDEITVSYGDDYFGDNNEECLCHTCEDRQQNGWAPMKRVEDSDDEDMEEAESPVENPSEATSSGTATSGGKRARDITEEDAGADLPPTSKRARIEKKPSPTKARASDHLREATLKKVHSTSSLRREMPVSSIEDPSANINVTSPQMTQDIRNQQRDGLLTVSLDETSSSRESTPQSPLMAASPKSSHSTDATSVDDEHHVDSLPKIKVEPEVVHENPALGVATVKEEVITTTVNAPWPSPPAEDDEMSDLSELSDSMEFDSVKQQIVKRKFRPTLRTTRSKSRYEVHNRVGTPVSSAVGQDGEWVENPRKPGDYMTSSSLLSAKFSKWVECQTCDVQFVQQDGYNTRKECPRCERHSKLYGYAWPKTEREGKHDKEERITDHRIVHRFVDPDEERELKRGKTKKILKESIRERFSTPRSGRESMSASVEVDSGRKRRRVRKTM
The following text describes a protein:
Function:
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
Sequence:
MAVLKSILDTDLYKFTMLQAVMEHYPNTPVSYQFKNRSPAMALNEEAIDWLKKEIDSLKTLSLQDDEEKWMRETCPYLSDEFFTFLRGYRFCPSEQVVLTYDETNKDLGIAINGMWHETILYEIPILALVSEAYFKFVDKDWDYEGQLDKAFDKGKRLIENGCVFSEFGTRRRRDVHTQDLVMQGLVKARQEVNGAGAFSGTSNVYFARKYNVKPIGTVAHEWYMGTAAITNNYTAANYVASVKWRQTFGKNLGIALTDTFSTDAFLRSFTANSPDDLANVYDGVRQDSGSPEEFIKKVVRHYKAIGVNPGTKQIVHSDSLNVDRCIHLQKLCNEAGIGCSFGIGTNFTSDFTRKSDRTQKSKPMNIVVKLYSAGGRKAVKISDDIMKNTGDKLAVEQAKRELKLPIAAN
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Sequence:
MRIEDVYIWDINAKWLGISPVQLMENAGAGVARTIEERFGKGLKVAVFSGTGNNGGDGFVATRHLSFENDVTLFLVGDEAKIRSEEAKHNWEILKKLDFVKIRILKDSSYIKSLDLSEFDVIVDALLGAGTKGEPREPIRSAIEKINEYSGKAKIVSVDLPSGYPSDIRVKCDFAVTFQWDKEEYGGFERVIVKIGYPKELYHLVGPGDAKFALRKKGEHKGQNGKLLVIGGSEDYFGAPYLAAKAASYLVDLVYLAMPEYSARRINDPNVILRPFERRNFRKEDVEDVLAIADGVDAVVIGPGIGQRAETKEFVVEFLRWCEKPVVIDADALKAVAEDLDVLKGKNFVLTPHAGEFRILFGEKPEGSLEEKAKLVVEKAKGVGGTVLLKGAYDIISDGKGWKYNKTGNRGMTTGGTGDVLAGLVGALLALGNSPLRAASAGAFLNGLAGDMVKEEMGENFTALDVAEKVPQAVKWVLEF
The following text describes a protein:
Function:
Involved in inflammation.
Sequence:
MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTKEELANVLPISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKEKREQYSDFNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAAMRTSNTASRQPL
The following text describes a protein:
Function:
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Domain:
Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds.
Sequence:
MEEVLETMQLENMHCDVCEGTTFQEREGFYYCVECGTQKDQIRAVDITAEDNFDDTAAGRYTARTIRQKKDTEKEDEDDITSWEFYNYVLRGFLQELLNMGAKPELKLMTLQVWAAYLDSMEVAFSKSNKTGLPKLNVRALPIDARIIYNHKTFKKGKKGKKSTLTGDPNDERAKFRLWNRTKRNLDASGYRSHGGASESEGEQSLHLQWSMRARKSLKRHMPLKHLDKHSRDSKGSMSCHSLRPRVKQLHNFDRNIYCLNIIKLYVVLGIALNMVEDDIQLSDLLRFIDEEHLTKRCMLNYLPGNVAAKGKALLKDMELSKMKDKVTNKLLRVNIACMSRFINLSEYQKPNLHSLAERYILELALPPRLLKYVNSLLDLHPPTFFNAMTVHPYPRYEARTMAYILYAMKLLFGLDDLKERNISESAAKINEKLLEVGGDEAPLLFVFTEWMEFVEMRKVIVSHYNQSFARRFGVSTRTGCQVDDILAKEWKEKEQGETFGWMQGSAAMKRQHENLTHIIETMLKDHFGESSKESMEKEHIEFQPSLTPAHSYFNRILLQVSRSDGAKMKITIPDHMKVDHSARNLDPFVLETTELSQYLSQHGLKLRVEELACQEDIQNVGIFRPLTIIRGDGREYRANTEIKTETWISELKRKEKRPDFRFTQPTGTYGARYLKRITMRDARRVQLEINNPFWDVTETPSFLLKLNDNEIPLDSLSSLQTFEEGTMDPLNIPLDLPRRNLEKILNPEGSDRASDQVASDINDEPPSPETLLLQVSNFDCWLLHGYMKRIRRHDKHELRQLFPCSFRWLLETCASTIGIVWEELYEELLIVEVMYHHSIRDWSNHRNYLCIQHNTQEKDIRTLARTYKELW
The following text describes a protein:
Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Sequence:
MSMVNAMDLRLLTQFDTASLEEDRKKKMLYEEPISLEEAALNANDVMVAPSRKSYVHGCSHVQLLFETVGDRLRSAVDQVPDKEFLIFKREGIRKTYSQVATDAENLACGLLHLGLNKGDRIGIWGPNTYEWTTTQFATALAGMVLVNINPSYQSEELRYAIEKVGIRALITPPGFKKSNYYQSIKDILPEVTLKEPGKSGISSRNFSCFQHLIMFDEEDKIYPGAWKYTEVMKMGTEEDRHQLSKIERETQPDDALNIQYTSGTTGQPKGATLTHHNVLNNAFFVGLRAGYSEKKTIICIPNPLYHCFGCVMGVLAALTHLQTCVFPAPSFDALAALKAIHEEKCTALYGTPTMFIDMINHPEYTKYNYDSIRSGFIAGAPCPITLCRRLVQDMHMTDMQVCYGTTETSPVSFMSTRDDPPEQRIKSVGHIMDHLEAAIVDKRNCIVPRGVKGEVIVRGYSVMRCYWNSEEQTKKEITQDRWYHTGDIAVMHDNGTISIVGRSKDMIVRGGENIYPTEVEQFLFKHQAVEDVHVSLKTILRNVHPFQFQIVGVPDERFGEVVCAWVRLHESAEGKTTEEDIKAWCKGKIAHFKIPRYILFKKEHQFPLTVTGKVKKFEIREMSKIELGLQQVVSHFSEL
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MELGSILQFLENKTILLTGVTGFLAKIFVEKILRVQPNVKKLYLLLRAADATSASYRFHSEVIGKDLFRVAKETLGANFDAIISKKIIVVCGDIPGDMVVNAIIAAMVAHANQPCDEVIYHVGSSLQNPMRYSNFRDYLIQYFTNKPWMDKNGKPIKVNKPTIFNSISNFNRFIKIRYSPLLKVLELANIVFCQFFFNTYNNLNRKIKLVKQLVELYRPYLFFHGIFDDSNLDNLRIAVGMNDIEDDTFFMDPKSIDWDNYFLNTHIPGVVKFVF
The following text describes a protein:
Function:
Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl. Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. No known function in males.
Subcellular Localization:
Nucleus speckle. Note=Speckled subnuclear compartment.
Domain:
RS domain directs localization of proteins to the speckled subnuclear compartment and the purpose of this localization is to allow colocalization and co-concentration of components of the splicing and splicing regulatory machinery to permit relatively high rates and/or efficiencies of reaction and interaction.
Sequence:
MKMDADSSGTQHRDSRGSRSRSRREREYHGRSSERDSRKKEHKIPYFADEVREQDRLRRLRQRAHQSTRRTRSRSRSQSSIRESRHRRHRQRSRSRNRSRSRSSERKRRQRSRSRSSERRRRQRSPHRYNPPPKIINYYVQVPPQDFYGMSGMQQSFGYQRLPRPPPFPPAPYRYRQRPPFIGVPRFGYRNAGRPPY
The following text describes a protein:
Function:
Directly binds F-actin, which results in thickened and distorted F-actin fibers, and affects cellular F-actin localization. Thus, may be a host effector whose function is to disrupt host actin cytoskeletal structure, which may enhance invasion.
Subcellular Localization:
Secreted. Periplasm.
Sequence:
MEMDIQESLLRLLRPLGLQRAEALAGALAREAGASKGLHDSQVLARAHALSVAPVEGRLGDLVWQVRQREHDGAPQVDLRWGLHRLGLDAPSRASTRDLVRAYERRLADRNEPMVYSTLAERVAGSMAEHTSLFQGMAMAVEEARARRSDANRLRENAPWQGWLVGASRAGHEAALLACIGMGADARLPDASGNTPLHHAARFGHFSLVTPLVEAGADVAALNAHGWAPLHLAALHKHARACLHLMAHGANPEQPGWRGRTPTRMHRHEQTQAL
The following text describes a protein:
Function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
Sequence:
MSFSIGGTGTSCLAALGEMEQIICQLERGTLIQKFYPRKRPEKKTLMLRRETRQIIWSSVQTNGRSNYEGSLELREVKEVRPGKKSKDFEKWPEEAKKSEPRKCFVILHGNDFKLRTVSIVAFSEKEADMWLKGLKYLISDTVSAPYWLQIERWLRREFYLMEANGTASLKDVRSFLPKINCKISTAKLNEVFHEVDTRRRNELGFDDFTRLYQRLILPPASLPEYFDGLRMATYSQNGETVTLQEFRRFLTKEQQEDEGSPGGGHSEETVAKFINDYIQDPARDVSEPYLRLHEFIDFLFSRQNEIWDKRCDTVYQDMSRPLAHYWISSSHNTYLTGDQFSSESSVEAYARALRMGCRCIELDCWDGPDNMPLIFHGHTFTTRIKFMDVIRTIKEHAFITSEYPLILSIEQNCSLTQQRRMAQAMLEVFGEMLLTQPIDKAEAQLPSPQQLKRKIILKHKKLPENGMLVVDEAGKESAVLMRGNDESELDIRNTVKNGILYLEDPVDKGWNAHFFVLTQHKLFYTDSQRPDRDADGRDDEREENGFATNRQSRDGAVLSNDELHFGENWFHGKLSGGREEAEKLLQQFSHLGDGTFLVRESVTFVGDYCLSFWRQGKPNHCRIKLKQDKGVTKYYLMENVLFESLYSLIMYYRQNALRSAEFYITLKEPVPQPNKHETKEWYHQTTTREQSEIVLNQIPQDGAFLVRPSEKGTKAFVISFRAHGKFKHCRIRVEGRLYEMGGMEFESLVDLVNFYSKHPLYRKVTLTYPIPREMIRRINTMDVPEESGGYGYMDPATVTNENVTVKALYDYKAQRDDELSFCKHAIITNVVKRGNDWWLGDYGGKRQHYFPANYVQELSAMDDGTLVEEGANEPLMLGSLQKGSLDVHGAVVEMAYSNHPDIERILRIQNPTMQNVFEVGVQTKELAYEWMCAIKEAAQNASAMENERRKMERNSRVAKEMSDLIIYCRSVPFKHHPAAWVFYEMSSFPETKAEKYFLQAETRALFVRYHRNHLSRVYPKGQRLDSSNYHPTALWNCGSQMIALNFQTPDKPMQLNQAKFRDNGGCGYLLKPEFMFRDEFDPTDPNTLVGVGEVIVNVRIIGGRNLCKVSRNITSPLVEVEVLGASFDGGIKHRTRAIADNGLNPIWNEICEFRIANPHFAMIRFEVQDEDMFGEPNFIGQAVFPLGSIRTGYRSVVLRNKYSEELELATLLVHTSIRPLQTE
The following text describes a protein:
Function:
Probable histone demethylase.
Sequence:
MSDQPPPYTPLPLLSSFPPNPYPDQTPDPASTPTLVLPNPAFPNKRKRTGFRRKLPSGSPAAPVAVAASPSAQPPPRASAADDIIVINREPTAEAVTALTAGFPADSLTDEEIEAGVVSDVGGIEQVNYILIRNHLLTRWRETFNSWLAKESFATLIPPHCDHLLNAAYSFLVSHGHINFGVAPAIKERIPKEPTRHNTVIVVGAGLAGLAAARQLVAFGFKVVVLEGRKRCGGRVYTKKMEGGGRSAAGDLGGSVLTGTFGNPLGIVAKQLGLPMHKIRDKCPLYRPDGSPVDPEVDKKVEGTFNKLLDKSSLLRASMGDVAMDVSLGAALETLRQTDGDLSTDQEMNLFNWHLANLEYANAGLLSKLSLAFWDQDDPYDMVGDHCFLPGGNGRLVQSLAENVPIVYERTVHTIRYGGDGVQVVVNGGQVYEGDMALCTVPLGVLKNGGVKFVPELPQRKLDSIKRLGFGLLNKVAMLFPHVFWSTDLDTFGHLTEDPSHRGEFFLFYSYATVAGGPLLMALVAGEAAHNFETTPPTDAVSSVLKILRGIYEPQGIEVPDPLQSVCTRWGTDSFSLGSYSHVAVGASGDDYDILAESVGDGRLFFAGEATTRRYPATMHGAFISGLREAANITLHANARAAKSKVEKGPSTNTQACAALLMDLFRQPDLEFGSFSVIFGGQASDPKSPAILKVELGGPRKKGATEGGKADQHHSNKLLFQQLQSHFNQQQQLYVYTLLSRQQAMELREVRGGDEMRLHYLCEKLGVKLVGRKGLGPGADAVIASIKAERNSSRTKTRPSKLKIGIPKSKS
The following text describes a protein:
Function:
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.
Subcellular Localization:
Nucleus.
Sequence:
MFDEESNSCDDARHFAAIGKKGKENSDPDLEYKFKKSKKKSSKEELLESQMQCYKRLSDLLEKSKCYSMMLLNRIDDINLSAVLDLKNEAIKKNLEAEKLKNNKSSSSVKKRGRPRKRKNDEVDQLVPECKLARQSSGRLDSRVGDSQKDEELPSSSSSSMQPSSQDDFCNSTMNNSSEADDKKLDALNDEKKSQNTVINSNSSSSIGGVKISDDAMEKVHTDENTYKQPVLVSGGTLRKYQLDGVSWLMKLYINGVNGILADEMGLGKTIQCISLIADLICIDIPGPFLICGPLSTLYNWANEFKTFAPEVPYLLYYGNKTERMNLIPKIHKPVHVPSQNVYVKPVVITSYEVVMKDQRFLSKLPWQLLIIDEGHRIKNSKCKLIKELNAYTSPHRLLLTGTPLQNNLSELWTLLNFLIPEIFNHAGSFETWFDVNFLENVDNADEQIVQEEQKSNTLSKIHQILTPFMLRRLKTDVDIVIPPKKELLVVAPFAEKQKNIYKSIVNRTIAQLNEYNNDPYEALADEVSLADDCETLMKSRSLRASTRRKSANYKLAFADDNDEMQDEDSKSGSAKGDDDYEVDDDGLSAWVDAVIKSRQESESLRSVVNKNDKNSVFKEQPLKLCNILSLLRRCCNHPYLIKDPRLEDDSGKLLTTEDIVECSGKLKLADRMLKKLKQKGHRVLIFSQSTQLMNLLEDYCSFRKYKYCRLDGAMKINDRQDEIQRFNDEDIFIFMLSTRAGGLGINLTRADTVIIYDSDWNPQCDLQAQDRCHRIGQINPVVVYRLVAANSIDQLIVERANAKRKMEKMIIHKGKFKSSWDEGLADTSNTGSSYKFVDLNELVKILKETDYDDVIRDDTEMSDEKLDSLLDRSDLIQVWNDRKSGVIMSTSDSNVASNCTGLEK
The following text describes a protein:
Function:
One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.
Sequence:
MSANGDSTGEADAASAVKVPNSPSTAFAALSLCDQPSSSSSPQCSTSSAPFTPAHIKEIASSTALVAQLDAARKRPKPLIRSTGHIVERTDSHVNSNDADHHHLLSWKVAEFAYRKTTSIGSELPTLARGLFTERIGCSSAAEKHRIVVRGYDKFFNLGEMAWTKPESISRYTTAPYVLTFKENGCIIFVSALSPDELVVTSKHSLGSIEGADITHAQKGHEWLLYHLASVKRTEQQLAHELWRRNETAAFELCDDSFEEHVLAYSAARSGLHLHGLNANSPEFRTRTMPEVDEFANEWGFIPTRWLQLDSLDQVQSVTSRIEQTGAWEGEPIEGFVIRTHMPDAKAMQSLAETNVVSPPYAPGQAWFYKVKFDEPYLMYRDWRELARKMVKDKAEWETKVASLPAACTGHDSLDEAAPSLTIVQAESSASIPDNNVAHLGDADDSDAKGSSKAAIKRARKRLAKQTAKQAAAHRTAAQAAGLLPPSPPQPRSKRPETALFIQWCYDRLYGNAAAQVKPQPQLFAGLAQNKGIIAMRNAFLAYLAAHHASTSPSTSADEAARDAEQDTRPYTKTILAPIAVPGCGKTVLAVALSSLFNVGHVQSDDFKKKTGFLSAIEKHVRAHAADANYVVFADKNNHLLQHRDEVIQLGARLSQPAALPTGKKRRQVADVGRVRTVALAWELDTVPLNTLHRICASRIEARGDNHQTLVADADAASVSGLKSHEVVLWRFLEALQPFASSDAKGEGDEGYGDARFDEVIRLGVDMSVEENLRRVVNAMADKVGWEMPSDERLRDALDLAARWKVENKLISKSVPGSGADASKSSTDATMITPRYFGLAVELDVRQLLDSMLLTTDAVDEGILRFYTSMRDSNRLNRRPHITLVHHSSRSAPSTSSPNNADEKWSFYTTLLSQPLDHASSTSSPTGAHLVFNVSISNLLYEPDTLFTLPVDQITPPDIIHSRFHHLHYPPPPSPPWTPHITLATHPNIPPYEANRLVSQWISNTHHANVQVLNLPTQLTVQARVFAMS
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MRESVWVLGGCQQSFLYKSREQKLLLMNNIKVSHITPDALQSILQKLAWYGDITHKLHHMIDSVITRSFGCHDNGEPSVSRTQQAFTSALLRCLQDFNKKLAALEKRLVLQEELITLSTMMGTLQEQFGDLEMLYTVYQLGVVSPSTDKTNDVLKASRLLSVLYQNILQYNTLGDAANTKLPLLLPLWIQTLRPYLEIIDGWVNKGNLIDPAMEFIIQRNGKVDVFHEDFWESAFLVSCSPVHQDDTPGSSMKEDGQEENLHEGKTDKETRENQEEEFIPVFLKSVFKEIILAGKSMELLKALGKMGGRVEFPVPLYEEFVQSLQTFLEVTDDLDQTGSSLCPPDHVGPVMVSSAMLHRVLDTAVKDSLLDKNFLKAIVMDSSEQEQDGTRTGVPLEGSQPVQLALQRCLYPHILQRCSTVSRLLVELLKTEYQLEDYLQAMQKFFLMEAGDAMHNFYMPLFAKLSAGEEWQDVSVLNSQLHSAIQQHHGQDADRLSVTIEASQVGGEPQSIHQLQELTLCYRVPWPVDIVITSACQHVYNQVFQFLLQLKWAKYCLDELKFADLRSPDVQAETDQPEESDDIPARQKEHRMHLLRLRLLHFINALHSYFMTRILYTTALEFRKEFSEASDLSRVVEAHTAFLTKLYQRCMLHKKAGLLKMAVRRMLNMAVSFQTLWDHGLHNISLESLETIEDEFKKCNDFLGSFFINMSRRGSFPHMESLALSLRMGST
The following text describes a protein:
Function:
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.
Subcellular Localization:
Nucleus. Note=Associates with chromatin during S phase.
Sequence:
MVQIVISSARAGGLAEWVLMELQGEIEARYSTGLAGNLLGDLHYTTEGIPVLIVGHHILYGKIIHLEKPFAVLVKHTPGDQDCDELGRETGTRYLVTALIKDKILFKTRPKPIITSVPKKV
The following text describes a protein:
Function:
May have dual functions, one in vegetative cells at starvation involving cell-type choice and a later function involving progression to the tipped mound stage. Involved in vesicle fusion in endo- and exocytosis. Involved in L.pneumophila intracellular growth.
Subcellular Localization:
Cytoplasm. Note=Mostly found in the cytosol but also found associated with both small organelles or vesicles.
Sequence:
MKLIAFIAFLLILITIINAQGSIGSSSQSLSSEVDSSDISSSGSNSTASSEGSVSSSSNSGSQSTSNSGSEASGSSNSGSQSTSNSGSEASGSSNSGSQSSTDSSNSGSQGSTGSSNSGSQSSTDSSNSGSQSSTDSSNSGSQGSTGSSNSGSESSGSSNSGSEGSTGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSSGSSNSGSESSGSSNSGSESSSDSGSSSDGKTTCISFHDTLSINTVDDDEIECTGKGETRCISDNNYKCATKQRHGSIECSVNGYIRCTGSNIKCKIGNTECSIRNSRLDITEKPIFTRGPRHH
The following text describes a protein:
Function:
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Sequence:
MATKVVFSLLPLLNRFDKSLLESYFQDGLRLIHYDVMDQFVHNTAFKGEYLDELKTIGFDVNVHLMVEQIIPQINFYLSQPNVKRISFHVEPFSFAKIKELIQLVKENGKEVGLAFKFTTNLQLYQPFFTTIDFITLMSVPPGKGGQAFNEAVFTNLKIANHYNLKIEIDGGIKVNNIDQIKAFVDFIVMGSGFIKLEQWQRQKLLQTI
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSNDTLTFINGLTSFYGSRANEVQDALVASRVHIVRYTTLERQQKRYGRQERIRGHVVRPRSGHGELHELTHNPAPVDYALALEMHELWCAYCQKIMCLDQKAFATVDLHGARIRVLRSSMPSYVGVEGICVRDTAATMELVTEANKHVFVPKASVDVGLFLPNGSTGMVYLVGKLLRRKGNKKVKRFDTELDGRIT
The following text describes a protein:
Function:
Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Also able to catalyze the reversible cleavage of D-ribulose 1-phosphate, but FucA has a higher affinity for L-fuculose 1-phosphate and L-lactaldehyde than for D-ribulose 1-phosphate and glycolaldehyde, respectively. FucA possesses a high specificity for the dihydroxyacetone phosphate (DHAP), but accepts a great variety of different aldehydes and has a strong preference for L-configurated alpha-hydroxy aldehydes. FucA generates a vicinal diol unit having the absolute (3R,4R)-cis configuration (D-erythro).
Miscellaneous:
MISCELLANEOUS: During catalysis the binding of dihydroxyacetone phosphate (DHAP) frees Glu-73 residue from its interaction with zinc ion. Then Glu-73 residue abstracts a proton from the C3 atom of dihydroxyacetone phosphate (DHAP) (or from the O4 atom of L-fuculose 1-phosphate (Fuc1P) in the backward reaction), and moves to transfer its proton to the aldehyde oxygen atom (or to the C3 atom of dihydroxyacetone phosphate (DHAP)).
Sequence:
MERNKLARQIIDTCLEMTRLGLNQGTAGNVSVRYQDGMLITPTGIPYEKLTESHIVFIDGNGKHEEGKLPSSEWRFHMAAYQSRPDANAVVHNHAVHCTAVSILNRSIPAIHYMIAAAGGNSIPCAPYATFGTRELSEHVALALKNRKATLLQHHGLIACEVNLEKALWLAHEVEVLAQLYLTTLAITDPVPVLSDEEIAVVLEKFKTYGLRIEE
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MEFQDFLLAASTGDLGAAPAAPEHVDLVEFRMDLAADPLAALDDYDGVLPVLATNRADWEGGAAADGGDRIDALAEAARTDCVAAVDIERSALVDDDTADGAEALAAARSTDTTTVVSAHDFDGTPSLSAMADLLGEACSLGDVGKLAVTPQDRGDALDVIRVTHEYSAAGMTVATMGMGDLGRHTRAVTPLYGSKLGYAPVADGETTAPGQYAPAALQALIADLQ