lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Subcellular Localization:
Cytoplasm.
Sequence:
MKEFDLESYDYYLPKELIASYPVLPKEKAKLLVYERRSQKITHTTFEHVLDFFPKNALIVLNDTKVIKARLFGSKHAFLPSKTTEVFFHRFFKNNTALTQIKGKIKVGDKIFFDANYHAEVLELLHNGQRLIAFYDNKTPLNQENILKLLEQYGHMPLPPYIKRADESLDAHEYQSVFAKHMGAVAAPTASLHFSQNTLEKLLKDFKHAFLTLHVGAGTFLSVETKDIREHQIHTEVLRIPKKSQEILQKSQEILCVGTTALRSVEYFKRLENPNQEAFECDIFLHFANPILHVNYLLTNFHLPKSSLLMLVSTMIGLEKTKEIYKTAIEKKYRFYSYGDGMLIL
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MSKRGLSPEEKQMRTLEFFHENDSFFTLKDLVKLVPKAKGVVAQSVEETVKSLVDDGMVHVEKVGTVNLFWSFSSEASLATSRALTGLKSERDRLEKERGELQTALDKSAADRLASEERESDLREIEVLRQDIAEMKAKLKVQSSNDPQVFEEKKNLSMMMSYCRNEYQIDRQKFCAQFELAEDFEEALDRIERVEGRQD
The following text describes a protein:
Function:
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein.
Sequence:
MYHTSPRGNDNNNMSFKTPKTFHTGGRVTRPSPTPSRAESLMEELGFGDSDLLSDGDENSSDGSYDEADSGLGGGKKAMVSNADVQALRKELKQTHQQREELLLKVKNFRESSQQYRASYEKEKANKWQQIKILRKSHEAHMQEKHQLIDSLQDIIRDQETRVLELEGGDTGAASTQSNSISSRLEQLIDALEEQQNQVAESREKQYTAEEALRQMQQNGHGGGGPDQHHPSPREDEDDDHKAERGNHGNQVVESGLRQELEEANSMIKQMQEEQKQHGGVTDYEKEVEQLQEEVGKLKDDCSRYKKEAQHQEQVRRRESKSLKQSEIEKLQLQKQLTRLQTEMANKMRELDELTAKQSETLNQSSGMSEDLERMKEEMKKQIQDLQTQLNEKENQIAELEAYKDKAMVLEVEVSKLTNELSDTKQSSDTALLASKGGHLKEIKKLQAANKSSAKRIKELEERLAHESENLLDSAKKQLLAQESLEEQLNEKSTELERVQEEYEELKANPKIVEVEKKVEVESEEAKRALLQFKLQNNKLKKDLSSLKDTHADTEKQLEDSKNEVDSLVQKLEEREQEMAEVQQQMEEEMKCLEEAKDEEIIRTKEAAEQESSFIFQKYSLMRTRFNQLRPGLLMIAQEYQQLRSMCSQFPLMLSKAIEDTKNEIGARLSKVAKHNEELHKKYQKELLLRKKYHNELIDLKGNIRVFARVRPLIKEDGGGANAKPVVTFDQDDDGLLNVLNKGRMSTFEVDKVFNQASSQEEVFNDVRPLIISSVDGYNVCIFAYGQTGSGKTFTMQGPAKNPGINQRALKLLFEDTAARSDYSFTITVSVMEIYNEMLRDLLSDDPSNKMDVKMATEGGLYVPGLTEVEVSSVGDINRVFATGHKNRSTACTDMNEHSSRSHALLCVNILGKNKASGKRTKGKLNLVDLAGSERVNKSGSSTDTQRLKEAQSINKSLSALGDVIQALRAKQGHIPYRNSKLTYLLQESLGGDSKTLMVVQVSPVAKNSGESHCSLSFAQRVRSVELGAASKRTDTAEVAALKDRLSQYEEVPTSASYSTPARAKTPTNKTLKVTPRR
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MAISAGKETFLGYSQDRVNPIFCHRAIMTTSSGIWIGDNPLNFTLPTLIFQIVMVFFIYRATHAVFRLFGQPIHVSQIVAGIILGPSILSRDAKFAKSIVSQKNYESVVTISIITYMLFFFVIGVKADLGVIPKVGKKAVAIAIFSTLLPIVFIYITALCLRHKIPPRFIQGQLILLLTDTWCITSYPVLSCLLSELNLLSSKLGRLAMSATLIAAIVHVIANSAIVTYQLAIKIGNPLQGVTALVSFFALMGLILLVLRPIVLWLIRRTPEGALLDQVSFVAVVTMAMACGMLSQMIGFDLIVGPFFFGLVLPGGPPLGSTLAERMDRLVMGLFLPMSMAFVGIRTDLTSVVDIKVWWLFETFVLVITVAKFVGVILPCLYCRMPPRETVSLGLMLSAKGLSEVYSLIMWAENFLLERQEFSMVVITILILGGITTPLIKYLYRPEDRYVAHKRRTLQHANPGDELRVLTCVHLQDNVKPIITLLEASGTSPDSPICTYLIHLIQLVGRTDTVLHPHKRHNHSSSATALSETDHIVNAFRLFEQEHPDGLSVLPYVCISPYNTMHDDICSLALDKKVTLVILPFHKSALADGSISFVSPSVQAVNVNVLQYAPCSIGILVDNGFPGRWSVIRRVAVYFLGGADDREALAYAMRMAKNAAVGLTVVRFLAPKELREEGQEERMDDKMLEYFQHQTVDGKRVVYKEQVVKDGEETVAVIRETSPEFSLLIVGRREGKESLLTSGMSIWREYPELGVIGDLLASTNFGGRVSTLVVQQQVRVTGAAAQAADGPKVAPTVVQVEPEPDNY
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Sequence:
MYVGCVGKDKHGDQIRSAAEADGTTMELEVSSDKRSGLCVVCRDGNSRTLVVHPSSASSLRDDFVSSAAAQEGQRSAKTVYTTAYASVVRVRQTLQLMTSSRCHTLPDGLKQLAAMGLANQRVLDDFGEGLVDVLGKLDIIIGNPEEMYDLAMMLQWVPSEMSDMVLAKKIATEMMCDRHGVRRVIMTRGAEPIIYAASAGESGEVPVVATCAHSAKLLATGAGDAFAGGFLAAMAAKPDDVAFCCRLSAQAATFMINHSLVTLRTDEACLAELQT
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MLYQNFRIFLQSRVSPSIWGQTYRCLYVHQNLCVAEKRGTTPVKSMQPTSKNDEVGVPLGAKVKDAGKTVWYTGIVIFGFLATGALLFAVFKELFWSESPQSVYSDALKKCTDYPRMKDLLGEPITGFCDGSGRRGRTNLRHSLYMKDGIEHLQIRFYVKGIRNQATVHAVMEKKDGKFEYKYLVAETENYPKEKIFLIDNRKHELNFQEF
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MFNGSAPPNGGGAEANTLAANQGIIKSILDALSRDDSKPVVSLDQHALLLETLLSDALPNTPILHPAQRQKLFNAIADKVGPDATADAVRQALPKLKIKPEKNVADLLIELGVRGLPTVDTARAVFQRFGLTEANPPDERMVSEILAILLSVDPAIFESDRVTNFANLVHALAAIQQQLSWPRIIRALDELDGFNPSFHGHMAGMADLLLHAPVQGQISAVSGLWGPWHHRLRQLQILHGLLALGSDTFSFATLPGRCILAPEQLTDAPNSIQNAAQPLLNSTYNSLDLVETLIEISASDDQNVRSAVQEVLEQAIKACPELILLGLVQIPQPWNAIHAELASQLLTMFMTPHNSSLLVFYRILHTQRDYLLNAFRNFYLENQLNLTRIVDVAQSLDMVDDLVEARPFAFALDVAALASRREAIDLDAWLQDNINRHGSDFIRAVLEFLDIKAKDDLAKPDPQAEQSFVPLTVQNVASFLKALRSNGESMTAEEIDFFKGVRNVCLQLHPRLMNLAPGAEGQEPGLQVVTFSQDIHEEADSWYRQMYEGKISIEDIVLLLQRTRASDNPREHQIFACMVHTLFDEYRWFEMYYPAAELEMTAVVFGSLIQYQLIDYIPLGIAIRYVLDALRNPPDSSMFKFGLQALLRFQNRLPEWPQLCQALLSMPHLQQSYPHIIRLVKMALAGQLPGADVGMPGGQSLEDKKAPFPAIRADPLPQDEEQRDPSEEITDKVLFLVNNLSPTNLESKLGDARQLITADTYRWFSNYLVLQRISIEPNNHGLYAQFLDGLDAKGLMTYILHETLAKCQMLLNNDKTVQSTQERNLLKNLGSWLGSLTLARDKPIRHRNIAFKELLIQGYDSNRLIVAIPFVCKIMEQCVKSNVFKPPNPWLMAVLRLMVELYQFAELKLNLKFEIEVLFKGLNVELKDVPPTTILRNRPSAELQQQQQQQQQQQQQQQQHQSRGHLQHLSQQQQQQAAAQMQLQHQRQHQQQLSQQPATGIAQDLERLSLAGGYSAAAGGRMGPQSQKASAAAAAVAAAGSGAQPGQSAAAAAAYTEALVSMLQSLPQYVVINPQLTMFSSNAALKRLIYIAIDRAIREIIAPVVERSVTIASISTRELVTKDFAMEGDEEKMRISAHQMAQNLAGSLALVTCKEPLRISMVANARTLLLSNGFTEQNVPEQALMVIMQENLDLACSVIEKAAMDKAVPEVDEGLTNAYSSRREHRTRGRGYYWDSAALAASQYAATLPDMLRLRPDGLVPAQLRVYDGFIRRMSPGVDADRSTPTSVHASSVSGPSESGYLEGAAAAAAAAGGAGGAGVLSAVALQEAGAQANLPTSLLPVAPSGTLSAQQSLEKFSQGMTELERLLEAANQESSLSELPQDHEIRHALRLIPMVAAQSASRDETALAFSQKVVQLLFKIESKLGREVYVLLLDRLCEISLKAAREVTAWLIYAEDERKFNVPVTVSLVRAGLVNVAELDVQLAKLILRDLGASVMDFSAQLALECLQEPACATRQQLGSTIEALQRAEQRGKATDASKRFLHALESGLLKSKVDVGNTALREQLAYCFAEWARLFQHSPNPEKSFIDYVTQLQTQGILKGEDISSMFFRVCTEVSVDSYIKQKAVGGSAAMGIFSPIDAFSRLIVLMIKYHADPTGVNNEQAKVHYLTKILSIVVLVLAQSHEELGVHFQQKPFFRLFSSLLHDLHATESSLGDAYTQTLLAISNTLNTLQPSFFPSFTFSWISLVSHRLFMPKLLETNQREGWGAFHRLFASLLRFMSPLLRNAELQDTSRQLYRGTLRILLILLHDFPEFLCDYHQSLCDLVPTSCIQLRNLILSAFPRNIRLPDPFSSSLQITLLPEMAQGPHIASNYVAALNQVEGLRAAIDAHFDQARGKNMSEQLKALLQNATRGTSSTSSIGSSKDEATSASSAVSLSEGGISTSLINSIVLYVGVRSTEAGRSNGNDESGQVVLRWLVVESAPEARFLVLTAAANQLRFPSSHTAYFSAALLQLFAESEDELVREQLVRVLLERLVIHRPHPWGLVTTFIELIKTQRHRIPRAPAEIQALLDHIAATLAASAHEDNHAQQHQHAHINGRSAFLAQQMMQQQQQQQQQA
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Involved in dosage compensation in males (X chromosome dosage compensation) by mediating formation of H3K36me3, a mark recognized by msl-3 component of the MSL complex. In addition to its role in dosage compensation in males, promotes germline stem cell differentiation in females: catalyzes formation of H3K36me3, promoting recruitment of msl-3 and subsequent recruitment of the ATAC complex, leading to transcription of genes, such as RpS19b.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to euchromatin.
Sequence:
MEESGPPSNPSPVASRGRGRGRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLNKNRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLKSDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPKDREYKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLDYHGLRLLHAWISENGNDDQLREALLDTLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEIFRIPKRERIEQMKEHEREADRQQKHVHASTALEDQRERESSNDRFRQDRFRRDTTSSRIGKPIRMSGNNTICTITTQQKGSNGAPDGMTRNDNRRRSDIGPPSEQRRTLSKELRRSLFERKVALDEAERRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTDTNEWFNSDDVPVPAPPRTELLTKALLSPDIDVGQGATDVEYKLPPGVDPLPPAWNWQVTSDGDIYYYNLRERISQWEPPSPEQRLQTLLEENTTQQPLHELQIDPAVLENELIQVDTDYVGSLSAKSLAQYIEAKVRERRDLRRSKLVSIRLISPRRDEDRLYNQLESRKYKENKEKIRRRKELYRRRKIEVLPDAVDEIPVPGKALPIQPYLFSSDEEETKVAAIEQPAAEEEQDSLNMAPSTSHAAMAALGKAVAQPTGLGTVGKRKLPMPPSVTVKKHRQEQRSKKVKSSQSPLTATSAREAHEKFRFEISGHVANFLRPYRKESCTLGRITSDEDYKFLVNRLSYHITTKEMRYCEVSGNPLSCTESVKHKSYDFINQYMRQKGPVYKKPAEND
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MAGHGIPRYSSLGERSEEALQQELRKIQNYQALDRLVRDKIAGHDYTPETLQKISELLSSNPEYYTVWNYRRRVLQHEFNLASSNDSEEAVTGQIAALIKKDLQFLIPLLRKFPKCYWIWNYRMWLLDEAKRLLPRAVARKFWQEELALVGKMLSLDSRNFHGWGYRRFVVESLEKLAPEDQEVRSMAQDEFEYAKKMIGTNLSNFSAWHYRTKLIQRLLSEQSASDETRKKMLDDELDLIHRALCDPYDQSLWFYHQNLMCTFDPSLSDQSMAPNLSNDERLKYLRKEIGEIQEMLDGAEDCKYIYQALIDCTLLARKVKGTMPSTDQENILSWLSELKKLDPLRCGRWLDFEKSLHADV
The following text describes a protein:
Function:
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation.
Subcellular Localization:
Nucleus.
Sequence:
MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTLANAGATAVHAIPGDTASGKPGTLKGAGMAGPGGLARSSRNDYMRSGLYSTFTIQSLQPQPPSHPRPSTVLPNTGPAGVAVPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNLKSEEPNMEPGLGRPLPPEVKVEEPKEELEAAASGEAGFVLEAVKAEPFEPKVDPEVPPAEGVPARLSAVAMETAAQAGSLTASTTPSTEIAQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGTGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles.
Sequence:
MPSTKPPKERPYGKSKIRCLRCGTREAVIRKYGLYLCRRCFREVAPQLGFKKYY
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MQITLPGVVLTNSPAEKQYVIVKIFSPAGLLSAFAKNGASLSCDFRESLFPISFSLFTIQQSPPKMRKVIQGELQNPFTTIKSSYPLLQSAGKMIQAILKTQWHEKPSPHLFSLFLNFLQRIPETQYPNFFSSMFLLKLLQHEGSLDLSRSCTLCKTPLESSTIYRYEGALFCEKHAHEETISFSQEEDHILRVIVQAKKFQELVCLAEFPIDIDTKIDALFSSFLSETSEPSSLYYKGKTLL
The following text describes a protein:
Function:
Chondroitin sulfate-, heparin- and hyaluronan-binding protein. May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity).
Subcellular Localization:
Cell projection, cilium, photoreceptor outer segment. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Photoreceptor inner segment.
Sequence:
MHLKTGLIFLAICLALQVQGSREIPSKTNHGEAKQLADASGSDKTERTTKRSRVSTIRRIFDMAKHRTKRSPFFSTGVKICPQESVKQILASHQAYYRLRVCQEAVWEAFRIFLDRIPDTSEYQNWVTACQRETFCIFDIGKNFSNSQEHLEIIQRRVKHRTFQERKDEISTDKTGGKKLEDIPSVSTGPPSASLSTYTLVPNGTLLNEIVNETKTPVKELGTNTVPELPAEQMVEFSVTLTDQEYTAELSDPNSPQYRQLAAKFQLQMQKIFEKLPGFKEIHVLGFKQKKEKDGSSSTIARYMVNFERDGSEIKSTADDISTIGSNKVENEKVPLSAKEEREISATKLTVTDLQQLVATALHEDRSLPVDLGTLRFTDEPIKPSSDFDNDIQGMVTIPLAGPDLDDTISAELPLVYPSPITVDQTRDIFVDEFTTGITDLSREIGGPEDFDSNFITSEPAFPTKPSREPPHDRSPDTEDITTDYQRFTVPFSALVSTDSPAKPEDSYLPPPADESDSNDLITDESPTEQVITPAVYTTGSFTLPTFLQATDKDTEAEMKKELVGVTEPLFKEADRDSLSGQAVKMMDELESSGDDILVTTSTYKTLPFLIGSSDLFATQPEVTFAAALPPDQTLLPTVTSPFYSHSVVIDQSPEVPDTLMPAAASALPDRASTGVQDIAAELDGAGVKSTAVLDEAEHGSGYISVQTTEPAEVTQAPTLKYVTTSSMTTAAKGKELVVFFSLRVTNMHFSDDLFNRSSQEYKALEQQFMQLLLPYLQSNLTGFKQLEILNFRNGSVIVNSKMKFARTVPYNITEAVHCVLEDFCDAAAQHLNLEIDSYSLDIEPADQADPCKFMACDEFSKCIMNEWTKEADCLCKPGYASQDGLPCRSLCEMEPHLCDNGGKCELVPGRGAVCRSPDQFTEPGLTS
The following text describes a protein:
Function:
Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
Sequence:
MTSRLQVIQGDITQLSVDAIVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQQGECQTGHAVITPAGKLSAKAVIHTVGPVWRGGEHQEAELLEEAYRNCLLLAEANHFRSIAFPAISTGVYGYPRAQAAEVAVRTVSDFITRYALPEQVYFVCYDEETARLYARLLTQQGDDPA
The following text describes a protein:
Function:
Negative regulator of transcription elongation.
Sequence:
MTGKQTPPTSPPTSHASRSQPAKTKTQTKTRTRVPQPRIDADADSSAADETRRSGRANKGQHTKLPDLLDEPAAPKTKGPAKADSKKGHSKAKSDTPRAQSAQSEEQGDEEDDAIIRCVCGDQRDIRGRQMICCDKCEAWQHNKCLGLPEGDFWEGKNYYCEQCHPQDHQELLAAMARGEKPWARKKGSKGNKPRPSDVKPDDKPQTPQPSASVPPSPAAAPPVQEPTPTPAPAPAPASLAVQTQDASNGHAETKVKSQPQSPAGEKRRHEAPAEKANASKKRRKSSQHQDKSAPPTPSVGDIDSLPATQKPFAEKLRDVLSPLIKTASDARGYRIPDGETATSLGARLAFQLNTAAVEHYGEPTAGDSPSSIRLRAIMFNAKKNPILVDRLLSGSLKPQELVSMPTEEMASEDKQKEFAAIREAAEKQMILTEETGPRLRKTHKGEEIVGEDNFDSQEFKQPTVQTRDSATEDASMQSPMSHRPPESPADAAHPLAVDTAGTPTDSVRRPSANFDLNAVFDKVRSPQHDQQTFMIRRQSSLQNQEKSHAAVDDADVDRLLKDEDNDVEMSGYSSDPTVCWQGTVSMQSMQPFDAVARFVAGGDFGQVVPWNKLLANVLSVQGRIESSKGDDYIRGIGHSETYDVAVLALSPVTTDGRGVMDHFYQYFHSRGRWGVVPVEDTGAGIMRDLYIIPIEAGGSNLPPFIDMLEYCTIETPRKEHMVLLALVAKLPEVKPELPATEHFERFPTQDIAAAQVAHQQPPSQQQPGPSPSPVTHNPHAPQYSPMAPSFPPAQHPQQPPPPGYYPQAAVPPPPAHHQIPRALEIMGPYIDAPVIAHILAQNLNTNQAISELQMINLRHIVEEHPDARTNFGVLTDLLRKNGGQGGGQGGQEQSA
The following text describes a protein:
Function:
Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
Miscellaneous:
MISCELLANEOUS: Present with 10400 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLITRLRVPTIKRPLLPITSHLVRHCIRTYVATNHGNVRPFITPYKSSLPVRCLIAQRHIRTFPSNDKFTTKASNIETILLRKNNEREFKQSLLADAKNFQERFKINLKWILIKNNRPFSLNEISIIASWLILSQILWLILSTTTFISFYLFVINSVFSQEYIHEKKIYERLLKWLLKDHKCSNQDLEITFSPEDKASMLVLSPDWESNSILIKRLNVRDEILDLDLKFHHINLNVSLKNWLLGRGLITNVSIYGIRGCLNLSNFINLVNSFQGDQKTENFLKTLNNVEITDSEILLKQSLSAQETPSLKFSIYNLSLPRLRLNHFISDILSAKTFSGSINNSLFNLFKRQQKLTAVIENNNKNRMASSKFDFTDNNQENYRTVTHQDDPNYVTTLRLNFININDLKFNGDGKFNWLKDGQVEILADIMLTNSTSHLSSESKYAVVDLKVTCRDLKTTFPQEPPVLSTGDSIVSLDELKPIITFINSYEGMANPILKDFSENERLTNSIIWNSPNVSINRQRKSYPLTTKVTSNSTKEIIKFHNQPNTNANEIVLRCKMVKNLSDLQLININQILDQITMELYVDLTKIVEDWEFKNKNDWMKQWGTTFASQLLLFGFGAMV
The following text describes a protein:
Function:
Transcription activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) mediated by calpain or its functional homolog. Regulates cytokinin signaling during cell division.
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus. Note=Localized primarily in plasma membrane or endoplasmic reticulum membrane as dormant form and, upon specific stress or signal, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP).
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MMKGLIGYRFSPTGEEVINHYLKNKLLGKYWLVDEAISEINILSHKPSKDLPKLARIQSEDLEWYFFSPIEYTNPNKMKMKRTTGSGFWKPTGVDREIRDKRGNGVVIGIKKTLVYHEGKSPHGVRTPWVMHEYHITCLPHHKRKYVVCQVKYKGEAAEISYEPSPSLVSDSHTVIAITGEPEPELQVEQPGKENLLGMSVDDLIEPMNQQEEPQGPHLAPNDDEFIRGLRHVDRGTVEYLFANEENMDGLSMNDLRIPMIVQQEDLSEWEGFNADTFFSDNNNNYNLNVHHQLTPYGDGYLNAFSGYNEGNPPDHELVMQENRNDHMPRKPVTGTIDYSSDSGSDAGSISTTSYQGTSSPNISVGSSSRHLSSCSSTDSCKDLQTCTDPSIISREIRELTQEVKQEIPRAVDAPMNNESSLVKTEKKGLFIVEDAMERNRKKPRFIYLMKMIIGNIISVLLPVKRLIPVKKL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MNGSNNYRQSQEDWHSSEFRQHVINQIMEAMRNSCNPTTKSAREMEAHIFGNADCKERYLNLVARLILHMKDNRKSDGPGTRRTSQTAPMLSQAFAQNQCNPTGNQTVPPVSRPNIQASVGGGANVNNPPALLTSALLSSSSNGPQPPTSISSQGQGLGYSQVSIASANAYCQQGQGTNQSQYPHQVQPNPSPCSQTVAFPNPSPYSQQPIMKSPHSSQPSQSPYALQQPIKSPHSNQSAQFAYVQQPIKSPHTQPQVGPSAYVQQQAIRSPHPSPQVNSGKGHHSQAHQQIIKSPLTTGHPANSYQQQQPSLKSPAHPQSVINNRSPYPAQNIKSPVQQPPMLNNRSPYPQPSIKSPYPQSQPQQQQSSKSPFYPQIVQAPTKSPLLAPSPVTNVTTPNSVTVSQSPATNANPGSVGSVGGSVPASSPLQSVNPSDDAAYMEKLRDLTKYIAPLRRLIDRTTKEGRKKEIHKMKSLLEILANPQKRVPLATLTKCESVLEKLQASFSPQSQPPSVAIGTTTNGIAATNTNGVTSIATTTSNSSSNTIVSTTSVGSAPVTTSSGLAPSQDVCKPLIDIIAANLNSPALAYALQQTCGPAFTTMRGPMTPLTEQTVKRKRIKYSDSKMRSEQENVIETEMTELDDLFVIEKNVHPLMDSESFLLKCSIDDASLPPVPSIYVIIPEDYPYSSAQCQTTTVEYRANPFFVTIIEDLSSRLLKMPRVTLTGILNAWVIKLSILKAYSKDEHEFENLHQQNSFIPESISSGLA
The following text describes a protein:
Function:
Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Melanosome membrane; Multi-pass membrane protein.
Sequence:
MASPRLETFCCPNRDAATQLVLAFQPEVFCGVCLGSAGAGLFFSLLQLLPKKGRGARKGPKAAAASAAASSSATILLLVSACDMLGALGIIFRSTVWLGFPNFIANISVVNGTDIWPAAFCVGSAMWIQLLYSAGFWWLFCYAVDSYLVVRRSAGLSTIVLYHMMTWGLAILLCVEGIAMLYYPSVSSCENGLEHAIPHYVTTYVPLVLVLVANPILFSRTVTAVASLLKGRQGIYTENERRLGTEIKVRFFKIMLVVVICWSSNIINEGLLFYLEMQPDINGSLLKNVRSAALITWIIMGVLNPMQGFLFTLAFYGWTGWKLDLQWRKSEIPWESLSTSTVAENAYGLPGENSVNFQDSKKTSVAPSHQSDEALSMLSEGLIQLPTMSFYLDIPLENEHRFPPHPNFQGEGGRGTRRALRNQTQPFGGRSSAHDGDLESLRRLA
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MNPSYLNQILSYPQRESLISECPALALLCYQELVAAFRKGKRIADPLSLRDDVTVLLSIGSLHELTDRIFSAAPHESALPPLWCTLRKALECAWDPRGDGERQCELTMVGGKLRFYKKKCDRMPLAQSSMRNALNMSRTRIREVIACALSGSLEPLGGRRNEPIAALLQFSRLIPPPSEERVVTSEGLAFCMQPLQQQWWTLVSVVLDRALAIMSGKGVSRATLWQLLAVLFALNTSDYVYLFPSKDDDLEAFQLLARLSEVGLVYPLICNGEKCFVLSPHFHHAICWSSTPSLCTAALLDDTRGPSSRLRREDEDTIITETNFRLYAYTKNPDMLRILDQFAVKEVDVVGMVVCYRVTRASFASALAKGIGANHILQFLTVKAHPSMIKQSNSEAGDPSCPVLPAASVGFGNTSEYRQGNIIPQSFCDQLFTWERECRRLIFRHDVVLLKNIGKEQMEIILNCLSNSGEQHAVVHRESGTLAIEQEVYTRVLSNFITPD
The following text describes a protein:
Function:
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Miscellaneous:
MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization.
Sequence:
MQMMTRKVLLNMELEEDDDEDGDIVLENFDQTIVCPTFGSLENQQDFRTPEFEEFNGKPDSLFFTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYESNLICHGLQLEATRSVSDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRSPFGNLNWFTKVLRVNESVIKPEQEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKYQVMNNVNKFGINRLVSSGIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEAQCNHVVINEITQEEERIPFTTCGKCIRVTLCASAVFFWILLIIASVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHIIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGIIAERIGGTVDNSVRPKLE
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.
Sequence:
MTAPGLPLLRAPNLAVPHAFTTRAGGVSAGPYAGLNLDDRSDDPRPVAENRARLAAALGFAADDFARLNQVHGVQVVHAQAPGFWEGDALVTATPGVLLAIGTADCYPLLLADPEAGVIGAAHAGWKGTVGRIGQRTVEQMVNLGARPERIHAAVGPGICGEQYEVGEDVAAQFRAAGLGEWVLEREGRTHLDLAGANRALLEGAGVGDLWVSGRCSTEADFYSYRRDAGQTGRMWAVIGLPRREGQTGEARA