lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSETFPETNTPVQTPSTESFVNKMNAGDKTIGNNIFSQDSDSNQQSSHQEPLSPPNPSPTPEKRQLDDEVDNSIEPESKKQKVEEETEASQTGVIQTEVSETVPEIESSVNKDSEPVNGVSEESENTNNEQEKPQEEAPEENPQEEVPEAKPQEEASGENPQEIPNDKPQDDEPDIQEVDPPKPVVPVFTEPAPKPPQEPDMNNLPENPIPQHQAKFVLNTIKAVKRNREAVPFLHPVDTVKLNVPFYYNYIPRPMDLSTIERKINLKAYEDVSQVVDDFNLMVKNCKKFNGEAAGISKMATNIQAQFEKLMVKVPPKELPAGTNVAEATSVATSPTTNKRKSVAESSSSHQHRDSVAAARPKRTIHPPKSKELPYETKPKNKKVAAELRFCNQTIKELMSKKHYNYNFPFLAPVDTVALNIPNYNEIVKQPMDLGTIQSKLANNEYENADDFEKDVRLVFKNCYLFNPEGTDVNMMGHRLEAVFDKKWANKPVPEPTPQNSDVSDREYSSEEEDNVEISEAMLSEIPAIQVMENQIIRMRKELDELKKEHLKKLREQQAARKKKKQQKGKRRAPKAKHTKDTQHQVQAPPEPPKLTPPQPVVTYEMKKQVSEMVPNLSDKKLNALIKIIQDDVQISNDDEVELDMDQLEDRTVLKLYDFLFGDKALKNSAGKKKKPVANNNLDELAHLRSQLALFDEGVNGQQGSDNGFMKVVNQEESSEDEASSESSEEE
The following text describes a protein:
Function:
Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.
Sequence:
MCFYGPVSFIKKILPAGSQKSCLLILGLDNAGKSTLTDRLAEIFNGESKESNNQVSEWSFTINNFRVQLWDINGELKNRQIWPKYYKKVNVLIFVLDSTDALRLSEARCVLCDVLMHQELDNAPLLIVSNKKDASGSLSMSTVIDLMGLYRLTGRDWTFEECSMRTGSGVQEIVNWINEKINNNRK
The following text describes a protein:
Function:
Involved in the degradation of cholesterol. Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids (By similarity). Is also involved in the formation of 3-keto-1,4-diene-steroid from 3-keto-4-ene-steroid (By similarity).
Sequence:
MFYMTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Sequence:
MSSAPLRVYVQCNPLLDVSAHVSDEFLVKYGLERGTAILLSERQKGIFDDIEKMPNVRYVPGGSGLNVARVAQWMQQAYKGKFVTYVGCIADDRYGKVLKEAAEHEGIVMAVEHTTKAGSGACAVCITGKERTLVADLGAANHLSSEHMRSPAVVRAMDESRIFYFSGFTLTVDVNHVLQACRKAREVDGLFMINLSAPFIMQFFSAQLGEVLPYTDIIVANRHEAKEFANMMKWDTDCVEEIARRAVSEVPYTGTKGRVVVFTRDIESTVLATKDGVETVPVPQLDQDKVIDMNGAGDAFMGGFLSAYAVGKDLRRCCETGHYTAQEVIQRDGCSFPEKPSFSP
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRIRHPQGTASFRVDDNATTLGELQSYIAEQSGIAALDQELKIGYPPKSLHISKLSESVLLSSEKIGIKKGEQVIAARKAGGSGASSSCGPQPSACSSASSLSYPTTSFGAIGAPKANVSTATGPRTSYGLGARTLQDALTARAPASSTSTASTSSKPGSVADGSVSIAIASSPSSRLTLKVVPDDNSCLFNSVGYVFTQRLGSDVCQNLRQTVASEIRSDREKYPDIVLGQPRDSYISKILSPTTWGGAIELSILSHHFGVEIDSIDVATGSVHRFGEDKAYENRAIIVYSGIHYDALTLQDGTDETTVFPNLTAIGLDETEDEVLSAAKQLCQELKKRRYYTDTASFSLKCKTCGTKLKGEKQAVQHAKQTGHGDFGEV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Domain:
The RING-type zinc finger domain is essential for ubiquitin ligase activity; The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.
Sequence:
MLIPQEALNSVKCNLCDKFLSYFPIYTCEKNLPICGRCSAILNDTNFRRATLFEQVAQYLKFPCIYHTAGCVENLFPDEVPNHEENCPYKIIACSQECMWQGSVNELLEHFEDTHPNAILRNSEFEISFLNSYDTYSLVVYEDELFSFKRKFDITENVLKCSVFCYKMLDPVTKYNYKIVVQNGTGTESVEFAPKSADTFLEENVTEISVENIRDRLKDPSVIIGTIQIFDQKEVSSLKKKLNPDINFEMLAELECPVCLHYIIPPIFQCVTGHSICGTCKEQITQCPLCQQDIKNTQNFTLEKMAFLLTYPCMNSENGCDFADKPGKLKQHQKYCLYGTHHCPLKDYESCKWKGSAKNIYRHIQDVHHDNMLEVDTVRLFLDGAYFQQEENTCYIMKYAEAIFKLHYRYYRECFYWAMQLIGPPEEAKNYKFEIDICDNNNNSRRLFLRNFCSSLKEKDDSFTDPDQYVFLTLNQIRSFLSEMLTFTVRIVK
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Preferentially localized to the nucleus.
Sequence:
MVQLLHSIKAHNDKVWSVSVHPTLPIIATASTDKSTKLYKLSARQKFPLVAKLEDTHKRSIRSVAFKPPLGGADTPKSDFLDLPALAAGSFDSTISVWGIDEPDVEYDIEEVIANQKEILTSPNNEWNLMAIIEGHENEVKAVDWNFQGQYLASCSRDKTVWIWETDPETLEEFECVAVLNDHSQDVKNVSWHPSMNILASSSYDDTIRIYQQDIAGDEWSCVGILNGHEGTVWCSKFESLKSPIADSSVLRLVSASDDLSVRIWVAKREQEDDEQAKLELPSSIRHTNEMVWEVESVLPSVHKYPVYSVAWSALTGKIASAGSDGKIVVYSETEKGKWVIDSIHEGAHGVHEINCVIWAQLDDENEILVSAGDDGYVNLWKI
The following text describes a protein:
Function:
Probable inactive glycosyltransferase.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Sequence:
MKSLLFGTPCSCAIFILVYCIITLFIWFLYTDNLSNAIVDFEYFSIKNLGELGKEAHLQMTETDLVDAQLQNEKYQYNAWLSERIPLKRTLEDYRDPQCLKINYSSEKTVTVSIVIAIQQEHPHTLLRGIYSVITQTSPYLLKEIVLVHDGHPDLDLIRHIHHKLPIVIQLEMESSKGIIHARLTGAGVATGDILVFLNGHMEVTRGWLPPLLEPILLNNQTVTEPIVDAISRESFAYRKLVEPEQLAFDWQLDHIFLPLDQHSWNSLPKPYPSSQLEGRVFAIDRKWFWHLGGWDEGLRDYGGDALELSLKVWQCGGLILAVPCSRVGIIYKRDELEAQMAPNRNPSLQVQKNFKRVVDVWLDEYKLHFYRYNPKLRNLTAESLDKPRDLRRRLNCKSFEWYRSQVAPQIRNHFLHAGLTNYPIGKIMPFVAPHFCLSIKGGFPVIRKCHSTNFEDWTLTSRCQLKHGNMCLDVDYKNNVRATKCTKKLSKNPWHYNYQHSSFVSNGNKCLQIDVNKVGLILSACDSDVTEQRWMFTKVQDFKLDHMRDICLSVNH
The following text describes a protein:
Function:
It is required for meiosis I chromosome division during sporulation. A component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase.
Miscellaneous:
MISCELLANEOUS: Its negative tail is functionally important; MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Sequence:
MSNKASDQSARTASILKTDITRENTITRSSSSNNDNYHHHNNINNYNESAKTGEDANKENIPNLEEEIAAFRIFRKKSTSNLKSSHTTSNLVKKTMFKRDLLKQDPKRKLQLQQRFASPTDRLVSPCSLKLNEHKVKMFGKKKKVNPMKLNFKGNLAADSEDVEIDEDEEYFY
The following text describes a protein:
Function:
May regulate transcription elongation by RNA polymerase II. May enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex.
Subcellular Localization:
Nucleus.
Sequence:
MPRRRDDDDELDPEDEQEDEEELEDEEDYDDGGGRGGSSKKRRRSEFIDDVAEEDDEEEDEDDEEDDFDGGHRSHKQRRRTGSEFFELEAAVDSDEEEDEEEGEDDFIVETGAELQDEEEGRRMRRRPLLPREDDQEDFEALERRIQERYARSSHTEYDEETTDVEQQALLPSVKDPKLWMVKCAIGREREVAVCLMQKFIDKGSELQIRSAIALDHLKNYIYIEADKEAHVREACKGMRNIYSAKVMLVPIKEMTDVLSVESKAIDLSRDTWVRMKIGTYKGDLAKVVDVDNVRQRVTVKLVPRIDLQAIANKLEGREVVKKKAFVPPPRFMNIDEAREMHIRVERRRDPITGDYFENIGGMMFKDGFLYKTVSMKSISAQNIQPTFDELEKFRKPGEDGAGDIASLSTLFANRKKGHFMKGDAVIVVKGDLKNLMGWVEKVEEENVHIRPKMKGLPATLAVNEKELCKYFKPGDHVKVVSGAQEGATGMVVKVEGHVLIIVSDTTKEDIRVFADNVVESSEVTSGVTKIGDYELHDLVLLDNMSFGVIIRVESEAFQVLKGVPDRPEVVLVKLREIKSKIERRVNAQDQSKNTVSVKDVVKILEGPCKGKQGPVEHIYRGILFIYDRHHLEHAGYICAKAQSCVLVGGSRANSDRNGDSLASRFPNLRASPHITQSPRRPPRGPPMDSGGRHRGGRGHDSLVGSTIKIRLGPFKGYRGRVVDVNGQSVRVELESQMKVVTVNRNQISDNVAVATPYRDTPRYGMGSETPMHPSRTPMHPYMTPMRDPGATPIHDGMRTPMRDRAWNPYAPMSPPRDNWDDANPSSWGTSPQYQPGSPPSRPYEAPTPGSGWANTPAGNYSEAGTPRENSPAYASAPSPYLPTTPGGQPMTPSSASYLPGTPGGQPMTPGSGGLDVMSPTIGGESEGPWFIPDILVNVRKSGEESGVGVVREVLPDGSCKVALGSTGNGETITVSQNEMEIVVPRKSDKIKIMSGVHRGATGKLIGIDGTDGIVKVDDTLDVKILDMVILAKLAQV
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.
Sequence:
MEVSNSCSSFSSSSVDSTKPSPSESSVNLSLSLTFPSTSPQREARQDWPPIKSRLRDTLKGRRLLRRGDDTSLFVKVYMEGVPIGRKLDLCVFSGYESLLENLSHMFDTSIICGNRDRKHHVLTYEDKDGDWMMVGDIPWDMFLETVRRLKITRPERY
The following text describes a protein:
Function:
Converts adenosine-3',5'-bisphosphate (PAP) to AMP.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGDDWLKPLVLLAKKAGAEILKYFGLSKEDLHVMQKEDRTPVTEADLSAHKILQKGLTALTPTIPILSEEGKIPPYAERQKWDRYWLLDPLDGTRGFIENRDEFTVNIALIERHEPVMGVVYAPVFDLCYFASRGQGAFKQVAEETPISIQTRKMDEDSFSVLLGQYLRSPRLPELFNAISGCEIVRLNSSLKFCWIAEGKGDLYPRLGDTSEWDTGAGHCVLNEAGGTILELNGKELRYNEKNSLMNPAFVAIGDVAQKEKVFELLERTP
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
QIPSVASRLLFIGHSNNCTNSVLSGNNLFENLDKYPLQDECQAALQEHINVEMHASLVYMQMAAHFDNNKVARKGFSTFFAENSKEEREHAQKIIDYINKRGSTVSLVNIDMPQITTWKSVLQALRDAISLENKVTNKLHAVHKTADEECKDPQLMDFIESEFLEEQVTSIDKLQRMITVLSNMDSGTGEYLLDRELLGDKKEF
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKYQSYHFFLLFLCSSLSFYPNMTKGSHVSITSLFHVGVVLDSNSVVGSAVWRCIERALLDFYAIHPSYGSRIILRVRDWKGDAYFSAVSLAMDLIEDVGVQAIIGPDDFLVALGNKVHIPIFSFSSYNFSLSPSQFPYFVRIAQNKDSSHVKEIAGIVQAYQRREVSVIHDDTDESEVVIPYLIDALREIGAQVRQRIILPYTAETEVIMDTLFMLEGTKTRVFIVHLCHSLGSSFILQVKEAGMMKPGYLWIATSAGLTDPTVHKHSTFCRSGEGVIIGVKPKLPPSQVAHMFENHRRRQVQKEDIDMEKIKLNVYAALWAYNALWVMTNAVEKADFGSTKNFWSTADDLSKMLAPKFEMVNATERQNQDKSGNPTHGSVISRRLLTSSGNATENILPNSTVQPEVTCKNASDVEILKIAVPYNTTFDSFVSVRNSMFNGFSIEVFDAVMSKLHYCYKYVAFDFGDSYNSMTDMVYHQEFDGAVGDITITAHRLNIVDFTQPYTGSGVRMIVPIQHERDTDGLWWFFKPFTLQLWLTTFVVFILKGVLVWLFENGKNPEFQGEHQLGRVLYFSFSLFVFAQKENLQTNYSRFVIYLWMFTLFVIVASYNANLTSILTVDNLRPSVTSLDQLVNDGSYVGYQKGSFVYDLLKERFPKEKLINLSTPTEFAQALSNKSVAAIVEEVPVINVFLKMYCNQFTIAGPTIQTGGFGFAFQKKYSTMISEVSEQILAISENQVLDGIENKYFGHQTCLDPSVQPS
The following text describes a protein:
Function:
Required for G2/M phase checkpoint control.
Sequence:
MTEFIGSRISLISKSDIRYVGILQDINSQDSTLALKHVRWCGTEGRKQDPSQEIPPSDNVFDYIVFRGSDVKDLRIEEPATTPSAPPVQPPNDPAIIGSNSGQYNWNQAQTAQPPQPVQPNPYGAPYQQAPPAGAPYYMYPNAPAQFVPPGGLPLGTPLDASTPAVPYYGAPDQQQMGQRPEFAQNVSQGFAGQAPYNVRPGYGMPSNQKPPNFAPGMPAPGPTAVSASPSLQSMPPTNGVIPGAQPSIEASIEKESTSIRNSTVTNDRVVNTTVDVSQSQTVETSGPSKEVPTTQPDASAAKPRTEFDFQTANQKFQSMKDDLLKGKNDEEAEEFYKPKQSFFDNISCESKEKGMEAADRRALRDRERSLNMETFGVAGSGNRGRRGRGRGRGGRGRGRGYARNQYNQYRNSNGSQPRAQPANDQ
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MPTLQGLRRKVKTIQNISHIIHSMETLSMVKIRALQDKSLRLKPYTEELNNILMELITRLPNEYLNHPLIRERSVYKTGILVFTSDLGFCGSYNLQIIESLKKFIEGKRAQNLVFYSIGFYAQRYLSSNNFNIRKKYIKFLEDTSFSQAKILSKDLLDDFLNYVIDELYVIYFEFINIVKQEVRIKKILPMIPVEVKERKEEYFLFLPSLSSILDPLLMDIFETQIHQIMLDSAASEQAFRRFAMKRAYDNAQKLHSKLIFQLNQLRQTQITKELLDITSSIEAMKEEVK
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein. Nucleus. Cytoplasm.
Sequence:
MLRQNLLDQLKHFIETVSNGHSCPQLLTSPNLIKLALGFLEELPATRDIVFEYFALLAEISVQLYVSPEMADPKTGMPVSQVKLAGNRQQQQRAPEYEAFNLVKTALQSLVWKGPPAWSPLIANWSLELVAKLSDKYTQRRMTITASCNYWLECSAMHGLMTLINSCFRKLTQPEEEACVEIMLNAFHRFPMTFDWIVARLGGCFPYKIIMQILQCGIKRFVDDYRCHLDSEAGILDYMTSCHEQHLRAAFREMLREGFAPKKPLDVAVVPFLLITTNYSDTILQSLVNVLVEIYTEDMCEVIVQKAPLWLSNKMFAGMQPTLNNAVLRLNERGATLLLTAAKMAEKYVWCQDFLDNSMQELEQWVLNQRNFPLLADLAYEETKYMLWKSCLSTNLFEQQTAVRLLLVVSSQHPNIYYQTISQLLKKSYAQNPNGIGALIRLLGGQSGMVNFPGFTPGFKMVLEDITLDVQVNNRLPVPPGTPTEAFNTFSNLNILARMHKSKNVAPYIKAQHLNQALNECLPKILQIFDCTVNKLVLRIDRDAAERIADKFRAQQSKNSNNNNELCNGKDYGKRTKLEPGEDKVDDEDATRMRLAHLIVDLLNNIEAGSRTTVLRTPLVLKLATLSVKYFFVGLTEKTVIRRAAASHRSYTLLQRQCSARKIARTVCLRELVERALFYHGHLLGQLEVYQLDELEIPEHEHLILQNLHTSSGANSNRSVLHSGIIGRGLRPVLPPSERNCDAEKQALYLKALNACCADLEKPNNVEGYSLVSLLLVELVSTDVMYNGLPFPDEEFTRVTMERDMLIRRAFINSPVLWAVLGLIAGHRPALCYSSVLLRALCATCLHHWRGKNVNRFQPTAANDELMLCTKKMLQLLAMSQLIPPPLTNLHLIIEHFESAEIALLLRECIWNYLKDHVPSPALFHVDNNGLHWRNTNTQLAKVPPQYVDPLRHLMQRKLSTLGPHYHQMFIMGELMEGDSEPDPTARLQIVEID
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MVRTILTYPDPVLKKKAVPVTIINDATRELVRDMAETMYDAQGVGLAAPQIGVSQRVIVIDVSQRDERPELIVCINPVIIHGEGESYEEEGCLSVPKYSANVHRHERVVVKSLNLEGEEVVHRAEGLLAIAFQHEIDHLDGVLFVDHLSALKKEMFKKKYRRMTEEE
The following text describes a protein:
Function:
Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA. Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).
Subcellular Localization:
Nucleus speckle.
Sequence:
MAETKDVFGQEPHPVEDDLYKERTRKRRKSDRDQRFRAFPSMEQSALKEYEKLESRTRRVLSNTYQKLIQSVFLDDSIPNGVKYLINRLLALIEKPTVDPIYIALFGSTGAGKSSLINAIIQQAMFLPVSGESICTSCIVQVSSGCCVQYEAKIHLLSDQEWREELKNLTKLLHRTEELSREEADAWNRDEAVEEATWKLQMIYGNGAESKNYEELLRAKPKRKIPTSRVITLKAEEAEELSIKLDPYIRTQRRDWDGEAAEMRIWPLIKHVEVTLPKSDLIPEGVVLVDIPGTGDFNSKRDEMWKKTIDKCSVIWVISDIERVSGGQAHEDLLNESIKACQRGFCRDVALVVTKMDKLHLPEYLRERKAGNQAIQSQREAVLERNEMIKLQRTRILKEKLKRKLPADFKVLEASDLVYTVSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYVTEAFGLLLLTDSFNSTQNLPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSKGNQGFHQTLKAVCLKNGIYASRTLARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALMPHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILGGLEDHILRRKRRIYESLTASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTGIVEKVKGSITTMLALASSQGDGLYKELADVGSEYKEMEKLHRSLREVAENARLRKGMQEFLLRASPSKAGPPGTSL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MAMAMEISLPFVGSSMALSAGKSRNSVSRISRVGFSSVSAVHVPRRMFMQLSGFGSVLTLLDFPSLAAPVPQMKEPEVIRTLKLPSGVRYQEIIEGEGREAHEGDLVELNYVCRRANGYFVHSTVDQFSGESSPVKLILDENDVIEGLKEVLVGMKAGGKRRALIPPSVGYINETLKPIPEEFGPRRSLLSHANEPLVFEIQLLKVL
The following text describes a protein:
Function:
Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKAQRSFGLALSWPRVTAVFLVDVLILAVASHCPDSWQADHHVAWWVGVGVAAVVTLLSVVSYHGITVISGLATWVRDWSADPGTTLGAGCTPAIDHQRRFGRDTVGVREYNGRLVSVIEVTCGESGPSGRHWHRKSPVPMLPVVAVADGLRQFDIHLDGIDIVSVLVRGGVDAAKASASLQEWEPQGWKSEERAGDRTVADRRRTWLVLRMNPQRNVAAVACRDSLASTLVAATERLVQDLDGQSCAARPVTADELTEVDSAVLADLEPTWSRPGWRHLKHFNGYATSFWVTPSDITSETLDELCLPDSPEVGTTVVTVRLTTRVGSPALSAWVRYHSDTRLPKEVAAGLNRLTGRQLAAVRASLPAPTHRPLLVIPSRNLRDHDELVLPVGQELEHATSSFVGQ
The following text describes a protein:
Function:
Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.
Subcellular Localization:
Nucleus.
Sequence:
MSNYVNDMWPGSPQEKDSPSASRSGGSSRLSSRSRSRSFSRSSRSRSRVSSRFSSRSRSRSRRSRSRSRSRRRHQRKYRRYSRSYSRSRSRSRSRRYRERRYGFSRRYYRSPSRSRSRSRSRSRSRSRERSYYGRAYAMARGRRYYGFGRTVYPEERSRWRDRSRTRSRSRTPFRLSEKDRMELLEIAKANAAKALGTTNIDLPASLRTVHVAKETSHGIGVSSNGAKPELSENVTEDGPRNPSEKPSQQRSIAFSSNNSVAKPIQKSAKAATEETSSRSPKIDKKKSPYGLWIPV
The following text describes a protein:
Function:
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions.
Subcellular Localization:
Cell junction, adherens junction.
Sequence:
MSGSREEERRKLADIINHWNANRLDLFEISQPTEDLEFHGVMRFYFQDRVAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEERKLDLDEKPLVVQLNWNKDDREGRFVLKNENDIAPKKTQSNGPEKQEKEGVIQNFKRTLSKKEKKKEKKRDKEAFPRIVDGDERSLNREDGENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDTADFAVAEALEKYGLEKENPRDYCIARYINQYDKGGKETILDDTECPLQIFRDWPSDKGALVFQLKKRPPDYIPKKARKPEEKVSRGRSVDVPLHSSLPPEKLPYLVELSPGRGNHYAYYNYRHQEDGSDSRDKPKLYRLQPSITEVGTEKMDDNSIQLFGPGILPYHCNLMHADGLVTVTPRSFEAETFVDGQRITETTVLRSGMKVQFGASHVFKFVDPSYDHSLSKRSMDSGPMVKGPRSKSGSVPETTFDLHGEIHSGAALPPSKSSGKLDMEHSGPTSNLSERGMVKPMVRGEQQDNRSQDGLGPELTLPASIEFRENSEDAFLSAIINYTNSSTVHFKLSPTYVLYMTCRYVLSSNYRPDMSPSERTHKVIAIVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDKDLSRITLDAQDVLAHLVQMAFKYLVHCLQSDLSNYMPAFLDDPEEQNPQRPKIEDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNKLVTESDSGLCSHYWGAILRQQLSHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYSMQDVPSIHNTCFKLNSLQLQALLQNYHCAPDEPYIPPELIDNVVAVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGFQEFLEPLCQRGFCRLIPHPRSPGTWTIYFEGADCDSHFSADNADLQMRKEPEVVTVTLKKHNGMGLSIVAAKGAGQDKLGIYIKSVVKGGAADMDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTGSVVTLEVAKQGAIYHGLATLLNQPSPMMQRASDRGRGSGKPRPKSEGFELYNNSAQNGSPESPQGPWGEYHEPKKITGEERLLKNRADHRSSPNVANQPQSPGGMPVYSGGPTAKITSVSTGNLCTDDQPPPPRPEAYPIPTQTYTREYFTFPAPKSQDRMGPGPGQQWQSYEDGVPGQHDDRHPGNMVIQRATRSQEELSDDRGLYYLERGRQEDLAHLQHREAEYQREHGSGEHWNHQVSSSVESSTSSQEHLNYSSSSKNAPNHKSGPGRWKTPIAPHSAPVAVSQPIRTDLPPPPPPPPPVQYATEFDSQAELPLPPPPAQQAADRKKREEQQRWYEKEKARLEEERDRKRREQERKLGHMRNPPGPVPLANQQIGPMPPPPQHQQLPPPPAPIPMQQPQSYLPPQQQQPPRPEKLSSIPRAPPPPQETVIRELLPQQQPRTIERRDLQYITISKEELSSSDSLSPDPWKRDAREKLEKQQQMHIVDLLDKEIQELQAKPERTAEENDRLRKLMLEWQFQKRLQESKQSEEDEEEDDDEDVDTMMIMQRLEAEKRVRLQDEERRRKQQLEEIRKREAEDRAKQEEERRWREEERARREAEEKRRQEEEYYTRLEAERRRQHEEAERKLLTPDEPGLYRPPLPRDYELPSPAPATNAPPPPPQRNTSYLKTQVISPDALYTAKFVSYTDDEEEDAGLAGQVKFSATRKSYGDLPPAPKHQQQPPSARPPRPVSDGIFLSSSFQLPAANANSTVPKAGPPPPPPAKPSFIPPGNSKGYNSYTGNATGVVGSHEVYKDPREKWGKGGQEQDTSVGSEAPESLTFKERQRLFSQGQDVSNKVKASRKLMELENELNTK
The following text describes a protein:
Function:
Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGLLSDPVRRRALARLVLRLNAPLCALSYAAGVAWFLALAFPPLTQRTYMSENAMGSTMVEEQFAGGERARGWARDFAAHRRKAGALPAAWLERAMRSVGLEVYTQSFSRKLPFPDEAHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDATNSQAVGLLLALAAHFRGQIYWAKDIIFLVTEQDLLGTEAWLEAYHDVNVTGMQSSPLQGRAGAIQAAVALELSTDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPQDWTSVDGPLQGLQTLLLMVLQQASGRPHGPHGLFLRYRVEALTIRGINSFRQYKYDLVAVGKALEGVFRKLNHLLERLHQSFFFYLLPALSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGVGPEEAGGGPESSPPLQPAQSVGLASLVAPLLISQAMGLALYILPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHSTQRVVSARAPDRGWMALKLVAIIYLALQLACIALTNFSLGFLLAVTMVPAAALTKPYGPRPLYATLLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLVAGGPGSPAFRTAPPYGHRARPGNTAHESPRAAPQTPRARNLRGPRHPRHRKMPAGPALLPVSTPPGSAARRSPAPSPALATPALGAAAGADGSRGAPETAKMAVAAASLRGAVLGPRGAGLPGAGARGLLCGARLGQLPLRTSQAVPLSSKAGPSRGRKVMLSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEDEAKALAEEVRGLGGGGPRDWGAHCAGRQGRDGALRGRWRFRTAPMRMERCSCGQGSSPTISPNHTPTLRPPEQPITEHCPLTSATSLELGTVVRTTSSPC
The following text describes a protein:
Function:
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKGIYSALMVPYNEDGSINEKGLREIIRYNIDKMKVDGLYVGGSTGENFMISTEEKKRVFEIAIDEAKDSVNLIAQVGSINLNEAVELGKYVTKLGYKCLSAVTPFYYKFDFSEIKDYYETIVRETGNYMIIYSIPFLTGVNMSLSQFGELFENEKIIGVKFTAGDFYLLERVRKAFPDKLIFAGFDEMLLPATVLGVDGAIGSTYNINGIRAKQIFELAKNSKIDEALKIQHTTNDLIEGILSNGLYQTIKEILKLEGVDAGYCRKPMKKISQKQIEFAKELHKKFLKN
The following text describes a protein:
Function:
Transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MADHKATSAAGSDAEVFLSASEDESVQQEITPELLSALVKQVEFYFSDANLPTDKKLLKQIRKDPDGFVPVKLFANFRKVRALSKDVAIITEALRNAKLLQLSEDGKRVKRLVAVPDYDISDIQRRTIVVENLPALPSPTIESVTDMFRMYGRVKLVRICSRESKGKLPSWLTSSCQNMQGQHAYVEFEDEEGAVLAAAALAQEYDAPDGAVQVRRLLACIAEHRERRSGAGASSFGGSSVQGGMSGSRKGSRDVSPNRPAAASSRRNSHGGMSSGGATMTNTSYGGAYSSCGGASSHGGWASMGGAAPADFGHAHLHVPHHHHSYGGAYEHFGGSRRGSGGGAPSCGGAALPPPPPPPRRSCDSAPASELLHSALVAPPPPPPPPPAHAPAMPLPVPSAAAAPAPAQPPRLNIYRPPAKRLSDGVSGVPASAASPLLRSSGGSFTSGGSSHCGSAASSLVPSAVSTPTVASQLASHTAPLVAVSPPLASRPMAVSAGGKPPVPHAAHAKPEPAAALPGNALAEAIAAAAAERRASEAGAKAPEAAVAAAPRAPISVAVAAAPSAPKFVLDLPAGASARRSSPPGTASGEAAVVSPSGAPLAPKMLRAAAPAGAMPVAAAAAPAARATQMVADVEGFINNILASSIPTPRNTGAAAGGKPAVRKQPAPKQLASPMHPQDAATAVAGILASALRSKASSAAAPAAVAPSAAAPAGPMIFLTAVMDGGDIAAADLEHAVTVSVHMPAAAAPKSAATTPAKGAGHSAVPKHSPSAALRSSGGGLTVGSTSPVLAAAASVSDGGAAGSGHVTPASAMVHVARGPDGSRGFGRRGLVA
The following text describes a protein:
Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MYIRKHSVNRPPTPDEDVRDSPERDELTLGEIINIKLVESGEKENLMELVRDRLVESGWKDEMRIACSPGIRGDEENLTYLWLSPRVKNGIWFLRIKNKLVERVGFSGWAKLVLEHVKKKGRKDVTVDELIRVITPKGRASVPDAVKEELLDRIHNFIRSAAL