lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Mitochondrion.
Sequence:
MLARAARRNLRSDAVVSHAKACEQLTLPWLCPAAFRRTTHTSALFTTTPTPAHTSDGRRAQRRSTSPPRRQSRSLATTAELQPTPAQSPFHGLMQAWGSRTPSPELARLTSWDRSNPLVLRDELSVPQLLSKRLPVYMGTSPLEMYQNLYACLRVDRVDRAAIILARLTDMLEPSAPELVDAHNMYFQTLLNLALQDPKPESMSRLEDWYALNFEAKGIKPTSSAFVTLLRGAMNFLEGAAQDEAIAKYVSMARQHGEDMVDEINYSSEFPDEEWNLLIRAQPDEFEEPPRVEEVRDMLVNTPESRKGFMELGLPSDFSQRISEHISNISINPVPQKGFGLDSLKHALSMFADETAVPYPHDMAGTQEDKDRHHAHMRQLRMEQDGLDAAVQRWKLEDEKLQQMGVYGVMNTKSIQALMYNWYSAVLPLFKKHIERAKEVMAAPTVEVGKDPLQIYGPWLERCKPEKLAALTVSRAVSSSFSRDGSRDTKSLKISALTVQLGTDIMDYLNADAQERRETFLKQQRQQLRKSLVGQLHKTDQKSDNSEQNAAQTATWTSGTVKTRFPVEVKTLLGALCLELLMQTATITFTANDLKSGKQLTSTQAAFHHGLEYVQGKKIGYLSPHPELVGKLRKDSVANIQPVNLPMIVEPKPWTSFQDGGYYTQPQRVVRQKAGDPAQRAYAESAIENGDMAKVLAGLDVLGKVPWQINAPILEVMLQAWNKGEGIAGLIPENHGLEPPVEPPADAPRVERAKWAKKLQEHENLKSGLHSQRCFQNFQLEIARAFAAEKKIYFPHSVDFRGRAYPLSPVLNHIGADLARGLLKFANGKELGTVGLHWLKIHLANLYGYDKASLKEREQFAMDNLSDIYDSATNPLDGRRWWLNAEDPWQCLACCMELKNAFDSADPTRYKSQFPVHQDGTCNGLQHYAALGGDHAGARQVNLEPSDRPQDIYTGVAELVKGMVKKDAEKGVDVAKFVDGRITRKVVKRTVMTNVYGVTFMGAKKQVEDELKAIFPKFEETEKIRSLGIVAMYVAIKIFEALGQIFNGAQEIQYWLGECGDRITTSLSAEQVEKIGQRGEGKEPTFDPKFKTPKKLTKTHVTNMNKAIEAFKTSIIWTTPLKMPVVQPYRKDSTTRVRAKFQDITVVKRSSHDIVDKRKQLQAFPPNFIHSLDATHMTLSALKCHELGLDFAAVHDSFWTHASDIPNLNVILRDAFVRMHSDDIVGRLAEEFKARYAGAMHMANISASSEAAKRIRLWRANHYGSGRGSPSKMAGGLRTVKASTEEIELEYKRQKLLKSDNPEEVKQGQEMETPTSIWLQHQDPKALTSHRLGLIGETKKEKKNRYDEMRDKVLDREADVIAEEKGQEDADMPSEEASDHGFRDLPDINEKTVIAVWIPLTFPPPPKKGGWDISRLRESNPALRGNAERDFYRTNNDWPITATAEIIRFCALGSNTNTLGFPRDHKSWSDAYLRMVMGKADRRPNNTDDDEGSKEEAERTRAKDRYLRLAMWRAERQESGTFEGRKRKEGEKRGRKKNVVGV
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Plays a role in the activation of monocytes and B-cells (By similarity). Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling (By similarity). Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates (By similarity). Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression (By similarity). Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment (By similarity).
Subcellular Localization:
Cell membrane. Cell junction. Membrane; Multi-pass membrane protein. Synapse. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.
Sequence:
MGMSSLKLLKFVLFFFNLIFWFCGCCILGLGIYLLIHSKFGVLFHNLPSLTLGNVLVIVGSVIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTLAILLFVYEQKLKEYVAEGLTESIQRYNSDNSTKAAWDSIQSFLQCCGVNGTSDWTSGPPASCPKGSAVKGCYIQAKQWFHSNFLYIGITTICVCVIQVLGMSFALTLNCQIDKTSQVLGL
The following text describes a protein:
Function:
Participates in cytokinesis. Necessary for microtubules and mitotic spindle organization. Involved in primary cilium formation.
Miscellaneous:
MISCELLANEOUS: Depletion of CEP126 by siRNA results in an increase in cytokinesis aberrant cells.
Subcellular Localization:
Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MLAGRPGTRSAVGELGTESSDNLDRAPLGPRESGGHHRPGSYLDMKIHLEKNLEEERQILLQQQKICRNRARKYFVESNRRKKAFEEKRKEQEEKEHQIREQILQQRKQKFEEVTEKFQRAHVPLSQRRKAVSRKPVPPLEEALKQIQESNLKSEVNLPFSRRPTINWRAIDSALPSALSKNDHKHQKQLLSKINCEKEMNENMRATLATSKNVFQLKLEETQKLLEDQHLSNLQKFCDEVNQITNSETLSSIDSLEATEHEEIYLTLNKEHSTSIQRNTISLKPANMQSTNLSCFDEDKLAFSKTQHINNWLTNLDASNTQNVTAFSDILSKSNVLPSWEYFNSKEQNPSPLNGTVERATNTANNSVPFVSSPPMFVLDKKCEKTSETSTMRTTDSTSGAFKRERPLVTESPTFKFSKSQSTSDSLTQEVATFPDQEKYSELNQENGTTSIPTSCVPVATPLVLPSNIQSARPSAKNSIHIKEIDAVQCSDKLDELKDGKEEEIKYFNCNKEELPLFSDSFQDAYIPHNPDSKDEKQKLAETSSLSNVTSNYDFVGQHKKMKYNIHERNGVRFLKSILKKESKYEHGYLKALIINQSFKFGNQKAAAIRDSIELTKEKGAEIPKTIKKLRWFDETSNIENNAENSHSLKNKTGTTQQHSQQFHIQSGAGSNIISVSTCAVNSADTKKSREDSISENVTTLGGSGADHMPLNCFIPSGYNFAKHAWPASKKEESKIPVHDDSKTKQGKPQRGRAKIIRKPGSAKVQSGFICTNRKGAVIQPQSASKVNIFTQAQGKLIIPCPPPQSTSNIRSGKNIQVSQCQPVTPENPQNIITHNSFNSKHVLPTEHSLNQWNQESSSPLSNACSDLVTVIPSLPSYCSSECQTFAKINHSNGTQAVARQDATLYCTQRSPVCEESYPSVTLRTAEEESVPLWKRGPNVLHQNKRATGSTVMRRKRIAETKRRNILEQKRQNPGSVGQKYSEQINNFGQSVLLSSSEPKQTTRGTSYIEEVSDSTSEFLMAENLVKASVPEDEILTVLNSKQIQKSNLPLNKTQQFNICTLSAEEQKILESLNDLSERLHYIQESICKNPSIKNTLQIIPLLEKREDRTSSCRDKR
The following text describes a protein:
Function:
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.
Sequence:
MALVRDDEPAAGSSRWLPTHVQVTVLRASGLRGKSSGAGSTSDAYTVIQVGREKYSTSVVEKTQGCPEWCEECSFELPPGALDGLLRAQETDAGPAPWASGPNAACELVLTTMHRSLIGVDKFLGRATVALDEVFRAGRAQHTQWYKLHSKPGKKEKERGEIQVTIQFTRNNLSASMFDLSMKDKPRSPFSKLKDKVKGKKKYDLESASAILPSSALEDPELGSLGKMGKAKGFFLRNKLRKSSLTQSNTSLGSDSTLSSTSGSLVYQGPGAELLTRSPSHSSWLATEAGRDSIQSPKLLTHKRTYSDEASQLRAAPPRALLELQGHLDGASRSSLCVNGSHVYNEEPQPPLRHRSSISGPFPSSSLHSVPPRSSEEGSRSSDDSWVRGSHGTSSLEAVPGQEELSKQTKVLAPGASCSAEEEGTRPPEGKPVQVATPMVASSEAIAAEKERKPRMGLFHHHHHQGLSRNEVGRRGSVGEKGSPSLGASPHHSSTGEEKAKSSWFGLRESKEPTQKPSLDVSPQVESDPAAPHPCFPQALVPPPAPAAAPMLSTNLFAAASPATATATAAAANIVLEATPSGFLGVTNPFLTSLQSNPFFEDLKADIALNSPSPAPSLPSASRASLAPLASPGKALPEWDDNFNIFAAGRLQSEAGSGILAPAGMGLEEDGLQDPGPRTLAVKATEPQGEPGGGRGGSSTWLEPKAPVDSVLDQPSTSMSDPGPLGSSGTGPSSRAAQLHLQASASTPDRELPASEGGAGQSPADSGASLFSSPEVLSVWERFPGSDDTPGGLEEEAAQDGSQLFQELNTVEDSWPWDVITISPTAEAASPVMKGESKGVLSSQVQPEYPDTVPPMGSEGLPSLQLEPEPEQGLDEGPWLGPPPPKPPRLFTPTNSQVEEDKEEEENATGGPSSRGPGVEDSTPSALVIGPPESKEEGVNSELEELHRLPSGTLIGEPELEDVVGETSSPGSRDCLPRPTSCPEGPIPRSHNSASSTLLSQKDWGTSETDESFETQSQELAKEGFGALSVPSQQADLWVKKEEEEEEKEAEEEEEEEASNPFSCQESQDPLSLPSTSPPGSRGSSTHSGPEELPTPPEPAFPPPPLPPWASHRHGVPGPPCPPLPIAWPLTSSSSLPEESACPLELSPTGGSPTPYGEDHAAATPASPLVLLPLETRPAEDPQPSGSPHPVKPLTAAPVEASPDRKQSRTSLSTALSSGLERLKTVTSGGIQSVLPASQLGSTVDTKRLKDSAVLDQSAKYYHLTHDELIGLLLQRERELSQRDEHVQELESYIDRLLVRIMETSPTLLQISPGPSK
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MGDASAVAPGGDSSKGSANFDSYIGSLISLTSKSDIRYEGVLYTIDAENCNIALQNVRSYGTEGRKKEGPQIPPRDSVYDYIIFRGSDIKDLQVKSSPQAHAVHSQPYNDPAIIAQSQQPQKAQRMSQPIMAPPIGMPQPPSGGVPPPQVPAGFSHAPAIPHPPVGMPPPRDSQALLPPGFLSSSYPPAVGLGAWGPRPPPPVGNALYWPGYYPPPSGNAMQPPYLPSQPLLPPDQRPPPQVSQPSSTHPTGPPETEKPRETTSSVGMTAILTPIAKLPRLPSVSQAPLDSSQELKKNTPTPLEQPPVEGVEPSKLQPAENSLQESSSHSKEQQANNGPRPENLRHEGPRHDGPRHEYNGRYNWRGNGRRGGRGRGPSQRTNFTEDFDFMAMNEKFNKDEVWGELGGKVEPRNGEDEPVSENWQKPEDGKKPVYVKDDFFDSLSCDTLDREGGTERPRFSEQRKINTETFGDAFLRSRGRGGYRGGYRGGQFRRGGRPHQPAAV
The following text describes a protein:
Function:
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes. Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin. Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity. Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism. Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
Miscellaneous:
MISCELLANEOUS: The major E4 form is first synthesized as an E1^E4 fusion protein from spliced E1^E4 transcripts, such that the first few amino acids of the E4 protein are derived from the N terminus of E1.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Domain:
The LLXLL motif located in the N-terminal of the protein is responsible for the association with host cytokeratins.
Sequence:
MADPAAATKYPLLKLLGSTWPTTPPRPIPKPSPWAPKKHRRLSSDQDQSQTPETPATPLSCCTETQWTVLQSSLHLTAHTKDGLTVIVTLHP
The following text describes a protein:
Function:
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
Sequence:
MYSAHRPLIPASGAASRGLGMFVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHEQPPGGTGGADPGRPPGATCPESPGPGPPLTLGGVDPGKSLPPTTEEEAPGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPASLGLAGGHKETRERSMSETGTAAAPGVSSELLSAAAQTLLSSDTKAPGSGPCGAERLHAVGGPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPTSFSGPKPSPQYGAPGSFAAPGEGGNLATSGRPPLLPSRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDSFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPGPPDPPAAFSKGYGPTPSSSSSPASTSVSVSTSFSLGSGTFKTQESGQGSTAVPLRPPPPGAGGPTTPSKATRFLPTDSATFRRKRPESVGSLEAPGSSVIAAPPSGGGNILQTLVLPPSKEDREGTRVPSAPAPSLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDTVGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPASPAVQFIAQGAPGSATPAGSGASAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTAGIPILQSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFESGTTGRTGPTPRQSLDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSSDWRVPGLGLESRGEPPTPPSPAPAPATGPSGSSSGSSEGSSGRAAGDTPERKEVTSSGKKMKVRPPPLKKTFDSVDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTETEDVLGELEYEKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEASLPGPPPTGMAATPVPTPSPAGGPDPTSPGSDSGTAQVAPPLPPPPEPGPGQPGWEGAPQPSPPPSGPSTAATGR
The following text describes a protein:
Function:
ATP-dependent kinase, which is specific for glucosamine. Does not show kinase activity with any other sugar.
Subcellular Localization:
Cytoplasm.
Sequence:
MNYYVGIDGGGTSCRARIRNQQGEWVGEAKSGSANIMLGVEVALRSVVDAITQAAEQGGLSPDDFPSMHVGLALAGAEQKEAWHAFMQQAHPFASITLNTDAYGACLGAHLGEEGAIMIAGTGSCGILLKGGKQYVVGGREFPISDQGSGAVMGLRLIQQVLLAQDGIRPHTPLCDVVMNHFNHDIDSIVAWSKTALPRDYGQFSPQIFSHAYCGDPLAIELLKQTAADIEMFLIALHHKGAERICLMGSIAERIQDWLSPPVQQWIVKPQSDAIEGALMFAGKPEHNLYKDGL
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSNIDETENQEYLLLKAKNIITERTQSSYLPDEYIGAEKEAETLYAILDDAIINKKSTVGLITGPKGSGKSSFFKHCLKKYNESDYLLVRLSGMIHFNDNYALKEIAKALGIKIPSGLNIFHTFEFIRVKLGKETLESQINTSTKKIQFQSLPVVILIEELELMLTSLSTSKQSLFYNLLDLSHYKNVSLSFIATTSQHDIVNMFEKRIKSRFTQESIKIPPLSFDSIQIIFKNLISLPESFDDEEYRDTWNANVEKSLKSTSVIENFKKYYRLYNRVNNYHLLVNEIIDNLDYYDKDNKWINSKIINDGFEYLNQDVIEIMLKSLSVLEFTILGCILNTKVGTNINDDYITFDELYDGEYKKLSYSFFKNVDQAKKPSTIRILQHLLLLGIIKTQSRANDSGDFPKFKIAIDPDSIINAAKNRNDLPTVIVKYVTEWLT
The following text describes a protein:
Function:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
Subcellular Localization:
Nucleus. Nucleus speckle.
Domain:
The BTB (POZ) domain mediates dimerization and interaction with CUL3; The MATH domain mediates interaction with protein-ubiquitin ligase substrates.
Sequence:
MSRVPSPPPPAEMTSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPDCRLADELGGLWEHSRFTDCSLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEAEVFKEMMFFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCTSLSVENAAEILILADLHSADQLKTQAVDFINYHASDVMETSGWKSMVASHPHLVAEAYRSLASAQCPFLGPPRKRLKQS
The following text describes a protein:
Function:
Cytoskeletal linker which probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MPPKGKKGKKGKKLPVLIDGVDTSAMTRDQLEAFALRLKAEMDREREERNYFQLERDKIRTFWEITRQQLDETRYELQQKDKEIEATQDLADIDTKHVMQQMKHLQFENHNRLGEVRAEAMTQLKLAQEHHVLQENELQRDKRQLRRMLRERMEMSEMQLRQMEAHFNEKLLEQRITFERERKDNEMLHEEKMIEQKAKLDLFYGTQMFEVEERKNQQIKDLQDHHDLAFNDMKNYYNDITLNNLALIGSMKEQLEHLRKQAERSDRIAADTAAENRRLKEPLEHANIQLNEYRRKLEFYERDKQQLSRLKTRNTRLEKKVKGLTWEAETLILRNDSLVAEREGLKERFNDVIVELQQKTGLKNVLLERKIAALMREDEKRSIVLHETIATCAPNFAEKLTSLDERVGNIIDEKNKIILDLRYEVTKARKAHDDLLETYECKLKQYGVPTDELGFKPIRNRDQQQLYVCGPAGIITENK
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Sequence:
MIKFFEKDPYAPIQYVYEVEKVLYKGKSKFQEIMVFENPYFGKILVLDGVVQLTERDEFIYHEMLTHVLMHAHPEAKNVAVIGGGDGGAVREVLKHGSVKKLYFIEIDEEVIKVSKEFFPSVSSAIDDSRVEIRCMDGAEFIKEMKNSLDVIIVDSTDIIGFAKSLFTVEFFKFVRDALTENGMFVTLSESLIFHRELVYEVQNSMKLIFPIVELYTASIATYAGNWWSFSVGSKSLDPREIRKPVKIETKLYTADLHKSCFLPRDIYKKLLNKELIW
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLYEMIGVVCLQCKCMGSDTVTDTARIAKTAGNIILSQQGVVRGYSNWGTFLLPKPAKKLQSTHHYGHHFIMRFDASARAQHALRRTMSLDPRLIRYSVVKMGEKFEHIKDVPGVAKFR
The following text describes a protein:
Function:
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFALFIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREKK
The following text describes a protein:
Function:
Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.
Sequence:
MEQQETVTRKKLYKSGKSWVAAATAFAVMGVSAVTTVSDTHKTPVGTTQSQQALTGQTGQDKPTTKEVIDKKEPVPESTTNNDSKSVHASGKNIDQQNELNKNTATENNKKTQDQNTATTPDTKESNKAVSDDQKITVQDDRNIALSKNLVDNKDAISTVITGGRYEQQDGHFVYLDQSGKKVIGLQNINGNVQYFDENGAQVKGDFRPGKEKNKVYFDKNTGNAIAYISNVHGVINGVDATGKQIKDNFLTDEKGNTYYFDSQGNMLKGLQTLDGKQYYFDEEGLLKKNYAATFNNQVIYFDSVTGIGKTALEYQFSQGLTDQKSDFTAHNAANSYDAKSFDNIQGFLTADSWYQPKDILKGGKTWVASTEDDKRPLLMTWWPDKQTQANYINYMSKTFATNDGIQYDATTNQSTLNLATQNIQVLIEQRIAQANSIQWLKNEMSNFIKEQFNWSKKSENIDYGGLQFQGGFLKYNNTPLASDTNSAFRLLNRVLFNRDGNSNVKGSEFLLANDVDNSNPVVQAEQLNWLHYLMNFGTITANDPDANFDSIRVDAVDNVDADLLDIARDYFNAVYKVNQSDVNANKHISILEDWSGLDPNEVVKNGNPQLTLNTGVQNSLLNALTKGPNNRWGIDSLIDKSTMRYPDKDGKILIPNYSFVRAHDSEVQGIIGKILTDHTSAESGNKFTKDQLKQALDYYYADQDKTVKEYSHYNMASAYAALLTNKNTIPRVYYGDMYKDNDSYMTSKTNEFDSIDALLKARIKYVSGNQEMGVDTKHQDVLTSVRNGNSRTEGIGVIISNNPNLNLGSDKITLSMGVNHANQMYRPLLLATDNGIDVYITDSSTTIRETTDGNGNLEFSSNYIKGYGINNSKVSGYLAVWVPVGADDKQDARVATSQNKTTDGSVFHANDALDTNVIYEGFSNFQQTPNLVDKDQRTNVIIAKEAKNGTFSNWGITSFQMPPQYRSSHDGTFVDSTIDNGYAFTDRYDLGFNNDDGTENPTKYGTVEDLRNAIKALHSKSIQAMADWVPDQIYNLSGQQVTSVTRVNEKGETWPNADIENVLYVVDTVGGGKYQAEYGGKYLGELQQKYPDLFTKPQITTGVPMDANTRIKEWSAKYFNGTNILGRGAYYVLKDWASNQYFNVNKADEAFLPLQLMNQDAKTGFVIDAVGVKYYSISGYQAKNSFIQDDNHNWYYFDNNGYMVRPENGKSGLVQMKVTNADGTVRESLDSSNKDGRYYYFMPNGMEIRNGFVKDIDGKSYYFNSVGEMLTNQYVFDASGNAYHLNSDGTMSTGLVLAGYNNVYHYYGLNGVQVKGKVAYDKNTNKWYSFDANSGDSQAFTDRPNNTQDFITIDTSSTLGVNADYTAYITSSVRQDGLFANAPYGVITKDQTGNDIKWEFINKDTKQYEGQQVQVTRQYTDSKGVSWNLITFAGGDLQGQKLWVDSRALTMTPFKTMNQISFISYANRNDGLFLNAPYQVKGYQLAGMSNQYKGQQVTIAGVANVSGKDWSLISFNGTQYGLIVSH
The following text describes a protein:
Function:
MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNSVTNPEIMPKKEEPKQNETEAETENKLSTADLKNGKSVSDSEKQNDLEGQTSQDSPYCALSLKRKTIIIGIVTIAGCLGPISGNIYIPILPQLENEFHVSTQVINGTVSAFMFVFAIAPLIWASWADYGGRKTLYLIPLIFFILANILLAATPANIVGLYILRVLQAFGASSVISVGAGTVADIIEPKHRAKAISVFMWGPQLGPVLGPVLSIIASKGQWRWIFGFLALFGFAVYLMILFFLPETLRYLVGNCACYKDTSIIVKPHLRQKKIVEGYPVPPKPSFKNYWILIKFKPVLLCSINSGLLFATFYGLMVTFAHVLKIEYSFTDAQISASYLCPGISLIIGSTIGGWASDKIRAEIIKHNPDIYVPEYRFSLQFLGLIISMTGVIGYGWTVHKHTNVVAVFIFTFLGGFGMTWVFVANTTYLTECTTGQPATNVAIGNFARNISATICTAIIDPLISSMGFGWCLTGLGLTNILGIVFVVILLKWGPSWRRQFLNKST
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-acyl-carrier-protein as the fatty acyl donor.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MLYIFRLIVTVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAENYGNAIYIANHQNNYDMVTAANIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRAKAHSTIAAVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKVNLNRLNNGLVIVEMLPPVDVSEYGKDQVRELAAHCRALMEQKIAELDKEVAEREATGKV
The following text describes a protein:
Function:
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to mouse (but not human) CCR6 and induce chemotactic activity of CCR6-expressing cells.
Subcellular Localization:
Secreted.
Sequence:
MRIHYLLFTFLLVLLSPLAAFTQIINNPITCMTNGAICWGPCPTAFRQIGNCGHFKVRCCKIR
The following text describes a protein:
Function:
[Tape measure protein pb2]: Functions as a tape measure protein that serves as a base for tail tube protein polymerization and acts as a template for tail length determination. Fills the tail tube with its long coiled-coil domain and is expelled during the conformation changes that follow T5 binding to host FhuA. Forms a channel through the outer-membrane after binding of the receptor binding protein pb5 with the host receptor FhuA; [Exolysin]: Displays an exolysin activity that is probably involved in the fusion with the host membrane and in the host peptidoglycan digestion necessary for viral DNA entry into the host cell.
Subcellular Localization:
[Tape measure protein pb2]: Virion. Note=Component of the tail. Located in the lumen of the tail tube. The C-terminus is located in the lumen of the baseplate, interacting with the base of the pb3 closed ring; [Exolysin]: Virion. Note=Component of the tail. Located in the lumen of the tail tube. The C-terminus is located in the lumen of the baseplate, interacting with the base of the pb3 closed ring.
Domain:
Probably forms a coiled-coil structure.
Sequence:
MTDKLIRELLIDVKQKGATRTAKSIENVSDALENAAAASELTNEQLGKMPRTLYSIERAADRAAKSLTKMQASRGMAGITKSIDGIGDKLDYLAIQLIEVTDKLEIGFDGVSRSVKAMGNDVAAATEKVQDRLYDTNRALGGTSKGFNDTAGAAGRASRALGNTSGSARGATRDFAAMAKIGGRLPIMYAALASNVFVLQTAFESLKVGDQLNRLEQFGTIVGTMTGTPVQTLALSLQNATNGAISFEEAMRQASSASAYGFDSEQLEQFGLVARRAAAVLGVDMTDALNRVIKGVSKQEIELLDELGVTIRLNDAYENYVKQLNATSTGIKYTVDSLTTYQKQQAYANEVIAESTRRFGYLDDALKATSWEQFAANANSALRSLQQSAATYLNPVMDTLNTFLYQTKSSQMRVSAMARSASAKTTPAENVTALIENAVGAREDLDTYLKESEERVKKAQELKQQLDDLKAKQAATAPIANALTAGGIGGDESNKLVVQLTNELARQNKEIEERTKTEKVLRQAVQDTGEALLRNGKLAEQLGAKMKYADTAVPGDKGVFEVDPNNLKAVSEIQKNFDFLKKSSSDTANNIRMAASSITNAKKASSDLNSVVKAVEDTSKVTGQSADTLVKNLNLGFSSLDQMKAAQKGLSEYVTAMDKSEQNALEVAKRKDEVYNQTKDKAKAEAAAREVLLRQQQEQLTAAKALLAINPNDPEALKQVAKIETEILNTKAQGFENAKKTKDYTDKILGVDREIALLNDRTMTSTQYRLAQLRLELQLEQEKTELYSKQADGQAKVEQSRRAQAQISREIWEAEKQGTASHVSALMDALEVSQTQRNVTGQSQILTERLSILQQQLELSKGNTEEELKYRNEIYKTSAALEQLKKQRESQMQQQVGSSVGATYTPTTGLIGEDKDFADMQNRMASYDQAISKLSELNSEATAVAQSMGNLTNAMIQFSQGSLDTTSMIASGMQTVASMIQYSTSQQVSAIDQAIAAEQKRDGKSEASKAKLKKLEAEKLKIQQDAAKKQIIIQTAVAVMQAATAVPYPFSIPLMVAAGLAGALALAQASSASGMSSIADSGADTTQYLTLGERQKNVDVSMQASSGELSYLRGDKGIGNANSFVPRAEGGMMYPGVSYQMGEHGTEVVTPMVPMKATPNDQLSDGSKTTSGRPIILNISTMDAASFRDFASNNSTAFRDAVELALNENGTTLKSLGNS
The following text describes a protein:
Function:
Ca(2+)-regulated actin-binding protein. Binds actin microfilaments (MFs). Involved in actin filament bundling, severing and capping. Caps the barbed end of actin filaments and is able to sever them in a calcium-dependent manner. MF severing is promoted by VLN1.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAVSMREVDAVFQGAGQKDGLEIWRIEKLQAVPVPKESHGRFFTGDSYVILKTTALKNGSFRHDIHYWLGKDTSQDEAGTAAIKTVELDAALGGRAVQYREVQGNETERFLSYFKPCIIPEEGGIASGFRHTEINEREHVTRLFVCRGKHTVHVKEVPFARSSLNHDDIFILDTKSKIFQFNGSNSSIQERAKALEVVQYLKDSNHEGKCDVGSVEDGKLMADADAGEFWGLFGGFAPLPRKTFSDLNGKDSAFSSKLICLNKGQTVPVDFDVLTRELLDSTKCYLLDCGSEIYVWMGRETPLEERKRAGSAAEELLREVNRPKSHIVRLMEGFETVIFRSKFSKWPKKADAVVSDESRGKVAALLKRQGFNVKGLAKAAPVKEEPQPQIDCTGNLQVWRVNGTEKTFLSFSEQCKFYSGDCYIFQYSYPGEEGEECLIGTWFGKKSVQDEKTTAISVASKMVESLKFQAVMVRLYEGKEPAEFFSIFQNLVIFKGGVSTGYKKFVSENGIEDDTYSENGVALFRVQGSGPENMQAIQVDTAATSLNSSYCYVLHDGDTLFTWIGNLSSSMDQELAERQLDVIKPNLQSRMLKEGSEYDQFWKLLGVKSEYPSQKIAKDQESDPHLFSCTFSKGVLKVREIFNFTQDDLMTEDVFILDCHSCVFVWVGQRVDTKMRAQALSVGEKFLELDILMENSSQETPVYVITEGSEPQFFTRFFTWDSAKSAMHGNSFERRLSIVKDGVKPKLDKPKRRPTTSSSHTGRSSVPEKSQRSRSMSFSPDRVRVRGRSPAFNALAANFENPNARNLSTPPPAIRKPSPKSPSSDPTKPPQRAASIAAISASFERPRPTLIPKSIKASPDVNKPQVEASKPKPEANGKDSTPSKDSPTVTPTIQEDLKEGQPENEEGLPVYPYERLRTSSINPVTDIDVTKRETYLSAAEFRERFGMTKEAFAKLPKWKQNRLKIALQLF
The following text describes a protein:
Function:
Tail completion protein that caps the tail and interacts with the connector gp16, thereby attaching the tail to the capsid.
Subcellular Localization:
Virion. Note=Forms a thin ring-like structure at the proximal tip of the tail.
Sequence:
MTWKLASRALQKATVENLESYQPLMEMVNQVTESPGKDDPYPYVVIGDQSSTPFETKSSFGENITMDFHVWGGTTRAEAQDISSRVLEALTYKPLMFEGFTFVAKKLVLAQVITDTDGVTKHGIIKVRFTINNN
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MHVVVVKEANLSTGIGADNQKTMAVAIGRSFSIQPGSLFNNKSLDRGSPAGRLSWLGDGAAATPRYRQTCVGAQQRPTWLPGLDPPPHLDGTLAGDFGFDPLGLAEDPASLRWYVQAELVHCRFAMLGVFGILVTDLLRVTGISKIPVWFEAGAVKYDFANTKTLFLVQLVLMGFVETKRYMDFVSPGSQAKEGSFFGLEASLKGLEPGYPGGPLLNPLGLAKDINNAHDWKLKEIKNGRLAMVAMLGIFVQASVTHVGPIDNLVEHLSNPWHKTIIQTLANSSS