lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
L-threonine kinase that catalyzes the conversion of L-threonine to L-threonine-O-3-phosphate. Involved in the de novo synthesis of adenosylcobalamin (coenzyme B12) and the assimilation of cobyric acid. Uses ATP; the activity with CTP, GTP or UTP is 6, 11, and 3% of the activity with ATP, respectively; The 1,2-propanediol (1,2-PD)-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low. This gene probably benefits from its induction via the Pdu promoter, rather than a physical interaction with the BMC.
Miscellaneous:
MISCELLANEOUS: Catalysis proceeds by a steady-state ordered bi-bi complex mechanism in which ATP is the first substrate to bind.
Subcellular Localization:
Cytoplasm.
Sequence:
MRAHYSYLKGDNVAVAQCPASCGELIQGWILGSEKLVSCPVDWYSTVAVTAAPPLINERPLSRAMVERVLAHWQYPAHWSNEIRVDVRSSIPVAKGMASSTADIAATAVATAHHLGHSLDETTLAQLCVSIEPTDSTVFHQLTLFDHNNAATQIACEPPPPIDLLVLESPVTLRTQDYHRLPRQQKLIASSATLQQAWNLVQEACITQNPLRLGEAATLSAIASQTLLPKPGFTALLSLVEECDLYGLNVAHSGSVVGLMLDRKRHDIARLKGKLAEKKLTRHWPKQHLLKMVTGGVKLQ
The following text describes a protein:
Function:
May play an important role in microtubule plus-end depolymerizing activity in mitotic cells.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton.
Sequence:
MAMGPPPEDGTVAVVVRVRPPTPSERDGAAHPVLHVVDQHILVFDPEEPGGPPGAALPPRGPKHRGKDLKFVFDRVFGEGATQEEVFQHTTREVLDGVLNGYNCSVFAYGATGAGKTYTMLGSEQSPGIMYLTMAELYRRIEARRDEKSCEVLVSYQEVYNEQIHDLLEPKGPLAIREDPEKGVVVQGLSFHQPKSAEQLLEMLANGNKNRTQHPTDANATSSRSHAVFQIYVKQQDRVVGLSQDLQVAKMSLIDLAGSERASVTNTKGERLREGANINRSLLALINVINALADAKSKKTHIPYRDSKLTRLLKDSIGGNCRTIMIAAVSPSSLAYEDTYNTLKYANRAKEIKLSLKSNVLSLDCHISKYATICEQLKTEVADLQAKLRAYEDAARDAGKQIPALLPPPRMEEAVPESCSAPNVCRESDGEQQELGAGQDAQLGGEEEVLEEMPPSSPSPTQQTDLQLGMKKPNRLPQRLSRSHTEMLMATILSVAQKQYSLLKAANLLTPDMVSEFEELQLLVQKEAAVSPQPTDTSGAPPALRTQRGCDASPSTLSAEPSVPTTRAALRRLQQLTALSSPKLVAKKRRRSEMSNTSRLETPHSLNTRAKRQRKSSPLSAGGEVEAQRSPHTPCLKEPQSPPLLPCCTPKICPLTVTKRRAPLMTSAAQNCCTPTVCDLNVTYSLSEDVAKPGALSLPRFPGWENAPCALKKQEGPFVPRASIPVFSMKGSSIPKPSSISKGSVQKRRGAVSNASRSLGGIQSHITSSSSRRSAQPQSIPEHPPPGLTWKGRSGPR
The following text describes a protein:
Function:
Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of the carbon-carbon double bond of crotonyl-CoA to yield butyryl-CoA. In vitro it can also use hexenoyl-CoA and dodecenoyl-CoA as substrates.
Miscellaneous:
MISCELLANEOUS: Possesses high activity for the reduction reaction, but no activity for the reverse oxidation reaction.
Sequence:
MIVKPMVRNNICLNAHPQGCKKGVEDQIEYTKKRITAEVKAGAKAPKNVLVLGCSNGYGLASRITAAFGYGAATIGVSFEKAGSETKYGTPGWYNNLAFDEAAKREGLYSVTIDGDAFSDEIKAQVIEEAKKKGIKFDLIVYSLASPVRTDPDTGIMHKSVLKPFGKTFTGKTVDPFTGELKEISAEPANDEEAAATVKVMGGEDWERWIKQLSKEGLLEEGCITLAYSYIGPEATQALYRKGTIGKAKEHLEATAHRLNKENPSIRAFVSVNKGLVTRASAVIPVIPLYLASLFKVMKEKGNHEGCIEQITRLYAERLYRKDGTIPVDEENRIRIDDWELEEDVQKAVSALMEKVTGENAESLTDLAGYRHDFLASNGFDVEGINYEAEVERFDRI
The following text describes a protein:
Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sequence:
MAATYRLVVSTVNHYSSVVIDRRFEQAIHYCTGTCHTFTHGVDCIVIHHSVCADLLHIPVSQFKDTDLDSLFLPHENGFSSAEGDYPHQALTGIPKVRKGSTFQSTCNLKDIAGEAISFASGKIKEFSLEKLKNSNHAAYKKGRKVKSDSFNRRSVDFDLLCGHYNHDGNSPSFGLLRSSSVEEKSLSRRNSLDTNLTSVFLHNFSEEDLVTQILEKHKIDNFSSGTDIKMCLDILLKCSEDLKKCTDIIKQCIKKKTGSSINEGNGNDAISSSETVYMNVMTRLASYLKKLPFEFMQSGNNEAIDLTELVSNMPNLQLTPFSPVFGTEQPPKYEDVVQLSPLDSGQFQTIELQDDQHSYRKTDTIKPIPNNSTNSLYNLEISDPRTLKDVQLQSQPLTVNPLENVSSGNLMETLYIEEESDGKKALYHEQKTENGPSQELIKVNEDRAELSDHGTHLKKCPASMQNEIGKIFEKSVVSLPEEDLKSKVPKVEEENHRDFINSNSQEEIDKLLMDLESFSQKMETSLREPLAKGKSSNSLNSQSQLIDQLPDLEPKSKVSSPTEKVSPSCLTRIIETNGHKIEEEDRALLLRILESIEDFAQELVECKSGRGSLSQEKEMMQILQETLTTSSQANLSVCRSPVGDKVKDTTSVVLIQQTPEVIKIQNKPEKKPGTPLPPPAPFPSSPRPPSPVPHVNNVVSATLSINIPRFYFPEGLPDACSNHEQTLSRIEAAFMDIEDQKADVYEMGKIAKACGCPLYWKAPMFRAAGGERTGFVSAQSFITIWRKLLSNHHDDASKFICLLAKPSCSSLEQDDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKITATEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWELDSDHDLYISQADLSRYNDQASSNRIIERIFSGAVTRGKTVQKEGRMSYADFVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPASDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPFAVQKDVENDSPEPSDWDRFAAEEYETLVAEESAQAQFQEGVHHEKRWTGRNTSWNQDCQEKYQ
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSCEKSSFILFYIFKTAHGPKPNRIMKIVCFTDSKSSTSLRICLVDSIFVFIFFYIVLIILRRTIYIDCRANWWYYSERALGLLELLDASLRQPIIILISTPQIHFWAPTFKWGISIANVADFAKPPEKLSYPQQIAVTCTGVIWSRYSTVITPKNWNLFSVNVAMAGTGIYQLSRKIKHDYFPEPEAAVAEE
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA (By similarity).
Sequence:
MNRIFPEQLNHHLAQGLARVYLLQGQDPLLLSETEDTICQVANLQGFDEKNTIQVDSQTDWAQLIESCQSIGLFFSKQILSLNLPENFTALLQKNLQELISVLHKDVLLILQVAKLAKGIEKQTWFITLNQYEPNTILINCQTPTVENLPRWVKNRTKAMGLDADNEAIQQLCYSYENNLLALKQALQLLDLLYPDHKLNYNRVISVVEQSSIFTPFQWIDALLVGKANRAKRILKGLQAEDVQPVILLRTLQRELFTLLELTKPQQRIVTTEKLPIQQIKTEFDRLKIWQNRRPLFLSAIQRLTYQTLYEIIQELANIERLAKQEFSDEVWIKLADLSVKICL
The following text describes a protein:
Function:
Required for mitochondrial fusion as well as normal mitochondrial morphology. May coordinate fusion of inner and outer membranes during mitochondrial fusion (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MNPYRPYVVVNNVEPTFSITPEPTFETQPTISKSEIFETLRSILVTKYLTTFFVQPLEVAKTVCQVEEYLPKRTKIERDGKQTKEPYDEDIPDGTEQEGLSDDEHEIYAYFETPTTEKAVTEQLAEKLCVDASGYVTDPSNLIERSYTIHSKRFSIKSIISELWEKEGARGLWKGHTISFLHNLLYSGLQSWLSATLSGALAIADPNIISPIDSVRPLLSLFIKSITSAISALILSPLDIARTKIILFPISSSSYLSSASETSGNSHKKFKPLTIRQCLKALPFYCPSSLILPTVCYVSLPPFVSSVLPLTFRNFLGSSPTLDAMVGLGTSAVQFLLKCPLEMVLRRAQAQYECNLPPQTIVPVGKYTGIVGTIWCLLSEEDPGKFGIEGLYRGWRVGIWGMSSTLALNYISSNLREEVEF
The following text describes a protein:
Function:
Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1. It is also involved in the dependence of mitosis on the completion of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSQHAKRKAGSLDLSPRGLDDRQAFGQLLKEVLALDKEHELGRSNSLPSMTSELVEVLIEVGLLAFKHDDSKSEFISPKMLKEAHLSLQALMLILKRSPTVLREIKSSVTLLDWILPRTISLFADIRFIKLFDSLKEFHKLIYQLISEKSFLWDLYASFMRYWKYYITNVSSIVLQITNATFPYKMPSPNSQPLQSITPNYPTHREDKFDLLIINIEEACTFFFESAHFFAQCSYLKKSNFPSPPLFTAWTWIKPCFFNFVILLKRISIGDSQLFLHLHSRIVQTLCCFSLNFIYHGLPICEKSKHILMSSINLTLGSLKKTYTVANTAISLFFLSLFVLPKTVAGLFYPFGVSLLSDFKVLEQLEPDSDLKKAIILFKCRYQSSEIDQTTLRAFGEICTGKLENTLFSNSELNLFLLHYLSLDNDLSNILKVDFQNGHNICTFAKWCINNNLDEPSNLKHFREMLDYYSSHNVTISEDDLKNFSLVLCTHVAKVNEKTNSIFRTYEVHGCEVCNSFCLLFDERSLFKIPYHELFCALLKNPDIISSSVKQSLLLDGFFRWSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDIVEFHKESKALIFNTLKILAVENTAILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIGLSALQQIASTRHISVWQLLSPYWPTVSVAIVQGMGKKPNIASLFAQLMNISEGDFLIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNLDISNEVLDQLLRCLLDCCVKYASTNMQISYLAAKNLGELGAIDPSRAKAQHIIKETVVLDNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNHEYSKMLNLGIEASWRSLSIDSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCHPNNKVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQSAILITEKLINLCNTRINSKSVKMSLKDHFRLSFDDPVDLVIPAKSFLDITLPAKDANRASHYPFPKTQPTLLKFEDEVDIMNSLQKPRKVYVRGTDGNLYPFLCKPKDDLRKDARLMEFNNLICKILRKDQEANRRNLCIRTYVVIPLNEECGFIEWVNHTRPFREILLKSYRQKNIPISYQEIKVDLDFALRSPNPGDIFEKKILPKFPPVFYEWFVESFPEPNNWVTSRQNYCRTLAVMSIVGYVLGLGDRHGENILFDEFTGEAIHVDFNCLFDKGLTFEKPEKVPFRLTHNMVDAMGPTGYEGGFRKASEITMRLLRSNQDTLMSVLESFLHDPLVEWNRKKSSSKYPNNEANEVLDIIRKKFQGFMPGETIPLSIEGQIQELIKSAVNPKNLVEMYIGWAAYF
The following text describes a protein:
Function:
Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.
Subcellular Localization:
Mitochondrion membrane; Peripheral membrane protein.
Sequence:
MAEEESVKVAVRVRPFNKREKARNSTLIVEMKGATTVLNDPSGENDPKRFTFDYSYWSHDSFKEEASGYLAPAKPHYADQNMVFKDVGMGVLANAWEGYNCSLFAYGQTGSGKSWSIVGYGPNKGIVPLFCDKLFVQIGEKTAGGETASFEVEFSMLEIYNEQVRDLLNPASKRKGGLKVRQHPKLGFYADGLKTVAVSSYQDIENRMEEGTKNRTVAATNMNATSSRAHTIVGIKFTQKYQNAAGEETAKSSVINLVDLAGSERAESTGATGDRLKEGAAINQSLSSLGNVISALVDKANGKKVRVPYRDSTLTKLLKNALGGNSKTIMIAAISPADINYDETLSTLRYADRAKQIKTKVAVNEDPTEKLIRELQEENEKLKKLLESGGIPTKLDDDSDDEDEEDVKSLSKDERERIRKEMEEEMQARILASQQEMEEMKKTWEEKMKQSHESGPVVPDAGAARKEKETTPHLYNLNVDPQLTGMIVHLLKPGEHLVGSSNEESGETPCILLKGLNIQPHHAALIVEGGKVYLDRCQTSPDAKIMVNGQPLTEKEELDHNDRILFGANHLYIFADPKQAGGKKSPAMTYEEAQAEINQNSGFVVGKPDSLGGSSLDELILQDDLVEVLPAIEQANTMSEEMDKKVKFEVAIIPAKKMGIVGSETEPPQRRPPEVLSTNRVMVKMRNVELGLEYLWTKAKFMNRKYLMDEMYESFSDGEDINWPDERDPFTEPPDHEEMIGALHIYLESIAYKIEAKEQLDLTNIKGIEVGKLNVELWPCTQTGKVLRDEDAFVDDPETDLKGQPIAFKVKILNARGLPDRFVDIYCKFKVYTMEPYQTQVIKKAINPDFKFEQLISFNAVDKLELDYLLNGSIFVQLFGKQVPKKREGKKLNTKQIMKKEGMLKGKDIGAENVPKHTVDEGKVGYQFQVLTLKKRLERLEKKMAQMNRVVDVAEKSSKMRVKTDTIKTVLRAKNPDAIEKAIKTIPKDKGAGDNEGVNGQPQSQESAACTLL
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
Sequence:
MSCNQQKECCKKECQEKECQEKECCCPRIKAFKKFINTFEKAQIGKEAPEFKAPAYCPCGSIKEIDINEYKGKYVVLLFYPLDWTFVCPTEMIGYSELAGQLKEINCEVIGVSVDSVYCHQAWCEADKSKGGVGKLTFPLVSDIKRCISIKYGMLNVEAGIARRGYVIIDDKGKVRYIQMNDDGIGRSTEETIRIVKAIQFSDEHGAVCPLNWKPGKDTIEPTPDGIKKYLTAH
The following text describes a protein:
Function:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrium between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
Subcellular Localization:
Mitochondrion.
Sequence:
MIALMRKFIHQAVKTGMKCGDRYFSIQIVQKAALAQFGAITVSKKLPLPAYAKAFSTVENTEDEMDKKKLSKPTFGNVGRKIHHRILQVLDSNGNSLGTMHRANVIRLMEEQNLRLVLRKANADPPVYQLMTGSQIHEEQLQIREKEKAQSKTGPPQLKELIFSSNIAQHDLNTKIKQIKQWIEKKYQVQITVKKDKTADPEDNMEELFNKILKTMPELATFTSKPKTTRGGKAATCVFRHLSKKEMAEYKNIKEETEKNRDSLNKEKSAITESNILQQ
The following text describes a protein:
Function:
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Sequence:
MDPLGAAKTQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPGGSSRQDTTPTRHTLLILLWTWPFHIPVALSRCSEMAPGTADCHITADRKVYPQADAVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFSLEPPPNCQHLEALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVHYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDPFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLQPRSFSWALDFCKACWKLQQESRYQMVRSIAAWFT
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSVLTSLLLRGLTGSARRLPVPRAKVHSMPPEEELGIMEKAIGLTFCFVSLFLPAGWILSHLEDYKRPE
The following text describes a protein:
Function:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Sequence:
MVAVAGPKAPGPRFGQSVVPNLNIKQICPNCRTDPPNIVEEYAKGDLVCADCGTILGDRIVDTRSEWRTFAGDENGDDPSRVGDAGNPLLGSNHLDTMISHKDGRTGIARDLNRAQARANTLSNGIYGKSSVAQLSAVFSRIGEKCDAMQLPRGVRERAQHVYKIVDEARAIKGKNEPAVIAACIVYACRDAKVHRTFQEVCKALKISKKELGQVFNHVKSVVQSSSAQGSMVSVHGSNNAQESAEGLLGRFANYLDLGNAVFNVSKHIAGEAVAKSAIDGRSPVSIAAGVLYFTCVLLGKSTTAKDISAMGGVSESTTKLITKMVASKLDDVIRPEWRTEYPDGYAALAQLGKVSESNKNSRSGSLAAQS
The following text describes a protein:
Function:
Contributes to plant defense. May regulate chloroplast metabolism upon infection with pathogens such as Pseudomonas syringae. Functions as activator of WRKY33 in plant defense against necrotrophic pathogens by stimulating the DNA-binding activity of WRKY33.
Subcellular Localization:
Plastid, chloroplast. Nucleus. Note=Can localize to both chloroplast and nucleus.
Sequence:
MESSSSTFLTTTSLDKKKPSPVSRKSPKQKKKTTSTNKPIKVRYISNPMRVQTCASKFRELVQELTGQDAVDLQPEPIYSPSSDDHNLSPPAENLAPRVLHQEPFGERDSDCYEPLNAEDMFLPDQMSAGFSGFFSNGFYNVNDFGSIDSM
The following text describes a protein:
Function:
Catalytic subunit of cellulose synthase. It incorporates glucose from uridine 5'-diphosphate glucose (UDP-alpha-D-glucose) to cellulose (a (1->4)-beta-D-glucan), which is produced as an extracellular component for mechanical and chemical protection at the onset of the stalk formation, when the cells exhibit multicellular behavior during culmination.
Miscellaneous:
MISCELLANEOUS: Amoebae missing dcsA exhibit snowmen-shaped fruiting bodies.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
There are two conserved domains in the globular part of the protein: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.
Sequence:
MDRNEGGDFPINTPNNINSSGGSYNNSMNNSSNNIGRDIGNNQSSRNLKPKPSQSNLKWIARDLKKKSVRKDSERKLKSSGVLKKKNTVMDFGEDDGGSGDDGNITEGLPISEGMDDLPSSSNSRGGSGNDEQKKQFPKEMNSPSSEYGTTSGGQRFDTLVDPDISLAEMEEKMRQHKVYQEQQQQQQQQQQQQKQKDKELSSQKKKPSSMQLSKKKHVAKEDSETLETIIGEEKKEVVFEVKPYFSHAILQATMAVFLIWNIFYFAYRAGWTMNRTDYITFSYSILFIIVEFISFLGSALHLNNFTNPCTFVLVVTLEQILAKRRKKHPTVMMYVCTYKEPPSIVSRTFRTAISMDYPSENLWIGLLDDSVNYRESRGWAHLQSVEKNFLYVLLQKAVYSVHNIRPPVTSQHEDPHGILNETSSKIESSTKEVIEAEVQWFIEYFLLNSWFGVGQEIPRDADDAERALIAKLRDDNFSPYRTFTKSESEKISNFTIDSLQSLWHGSAFFRPLIRSILLKKDYVRNFVSELNNQHRLRFLNTEALAMAQYQVLMMGRQELPWDEISSGNVRIDFDTCDGPIVSPKCTYLRRRKPPIPHNKAGNINNALFNESTKADYEFLGLLDADQQPHPDFLKRVLPYFYSDEGQDLAFVQTPQFFSNIYPVDDPLGHRNMEFYGPVMEGRSANNACPFVGTNAIFRRQPLYDIGGIMYNSVTEDMYTGMKLQVSGYKSWYHNEVLVVGTAPVDLKETLEQRKRWAQGAVEIFSLTPWGYIRGKLGWRKMLYNLDSCIYPFLSPTAFFYGASPLIMSIWTVPIVVKDPIIFILVGMIPVMVLPRVIQYMILRAKRPYEAGKSGPSLWVEATDLWRAEQTFFGFAGTYISSWREGSASIVKLLKARKISRHKLAMWNWKRDFVKKPVVCEVFRQTKLVNENDNAQESSGKHKAEQSFRTSNKESDTIKNSRLFLPNIILFVVNILAMMSAVLRFNCFQNDMWLLVVVAGFSFSTLWHLWSFIPMALRQSEKQWPYASSYHAHNIVLFLVLGFLVLLFVDVKVCIPRVG
The following text describes a protein:
Function:
Regulates the duration of MAPK8 activity in response to various stress stimuli (By similarity). Facilitates degradation of misfolded endoplasmic reticulum (ER) proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system.
Miscellaneous:
MISCELLANEOUS: Elevated expression in medulloblastomas. Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MRQPADGWREQALAEARVHDIDAAEIDYLIEAVTGLDRLRVRLGGPQALEAHREKLAALWRRRIEEAMPLQYLLGTAHWRDLQLQVNPAVLIPRPESEALVDVAVDFCRSCAGARVVDLGTGSGAIAVAVARALPGATVWAVDASEAALVVAGANIERYGLSEQVHLLRGNWFVPLPTQPFDAVLSNPPYIPSAEIAALMPEVRLHEPLSALDGGSDGLDAVRQIIADAARHLRPGGILALEVMAGQGPTVVQLLARDSRYGCIRTVRDWAGIERIVVTYAWARGS
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLLRSLRFFPVACTGRSARAVLLQPSQPWHTLHAGPSLSSSASSKELLMKLRRTTGYSFVNCKKALETCGGDLKQAEAWLHKQAQKEGWSKAAKLHGRKTKEGLIGLLQEENTAVLVEVNCETDFVSRNVKFQQLVQQVALGTMAHCQNLTDQLSTYSKGFLNSSELSELAAGPDGEGSLKDQLALAIGTLGENMSLKRAAWVKVPSGFYVGSYVHGEMQSPSLQNLVLGKYGALVICQTPEQITNLEEVGRRLGQHVVGMAPLSVGSLDDEPGGETETRMLPQPYLLDPSITLGQYVQPQGVTVVDFVRFECGEGEQVAEAE
The following text describes a protein:
Function:
Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP.
Sequence:
MSGLITRIGTVARCSPMAAAAAVAGIDAPRKRPRRPSSGSVRMEGSRSRGGDGGGCCCSSSGKGLAPAEPRLVVIVGATGTGKTKLSIDAAVALGGEVVNADKIQLYAGLDVTTNKVPHADRRGVPHHLLGAVRADAGELPAPSYRALAAEAAASVAARGRVPVVAGGSNSLIHALLADDRLGGGDPFKADDDDGCYRPSLRLPCCLLWVDVDGAVLDDYLDRRVDDMVREGMVEELREYFASTSPAERAAHAAGLGKAIGVPELGDHFAGRKTLAAAIDEIKANTRVLAAAQVRKIRRMADAWGWPVRRLDATPTVRARLAGAGRDAEAAAWERDVRGPGLAAMRQFLDSHHEQQQQQQRWPLARRQCRGMVG
The following text describes a protein:
Function:
Processive motor protein that can move over long distances along F-actin without disassociating; processiveness depends on high physiological Mg(2+) concentrations. Presents a high actin affinity in the presence of ADP, fast ATP hydrolysis, and a high steady-state ATPase activity in the presence of actin that is rate limited by ADP release. Physiological decrease of free Mg(2+) ions leads to an increased rate of ADP release and shortening of the fraction of time it spends in the strong acting binding states.
Subcellular Localization:
Contractile vacuole.
Sequence:
MTTSTIENGASSPIIVSSSTPKLYQEGAGVWIPDQELGWIGADVIEHSETSADQVLVRTEDDREVKIPLSKVFQKNPDILEGVDDLSFLSHLHEPAILHNLHHRYNLNQIYTYIGKILIAINPYTSLPLYGKEMISAYYGKQLGTLAPHVYAVAEDAFKDMRYDGTSQSILVSGESGAGKTETTKFLLQYFAAMGNMIKESTSSSSINGINTSSDGIPVTPPPSPMKKSPVDKSVEERVLESTPLLEAFGNAKTLRNDNSSRFGKFIEIHFNEMGSIIGAKILTYLLEKSRIVRQVYNERNYHIFYQLLSGASEELKEKLNLKTIEEYSYLNKSGCFEIEGVSDEEHFNKTCHAMQVAGITLVEQENVFRILSAILLIGNFEFENIAGSNDDSCQLIDRDPLEKVSVLLGCAQPDELLNSMLTRKVVTGKESYISHNTKERAENARDSLSMFLYGMMFDWLVVKINSSMSISTQQKSKSFIGVLDIYGFESFEVNGFEQFCINYANEKLQQLFNQHVFKEEQQEYIKEKIDWSYIDFNDNQDTLDLIEKKPICILTLLDEETMFPKATPQTLATKLYSKMTSHSKFEKPRFSSTAFTINHYAGKVTYETDQFLDKNKDFIIPEQISILQRSNFSFIKVLMSHSDKFTQSPGGHPQGNGGPTSSNTKGTSGSSSMKFLSVGSQFSTSLATLMKTISTTTPHYVRCIKPNPEKLPQTFNKQDVIHQLRCGGVMESVRICCAGFPTRRLLSEFYQRYKILYVKDINTGSGGGKKGSNNNKIKDPKILVQNLLTGIELSDDKYKIGLTKVFLRAGQLASLEDMRLEQLDRSATVIQKRWKGYLYRKRYKQLRDASLIIQTKLRSVHAKQQLSALQRTHSAILIQKVWRAHRDRVQYQKIRDASLQLQTVMRRHLFSEQVHRERCENAAIILQTKIRQILSKREVDKKLRGIILIQARWRMKLAKRVYIQLRAEARSLRTVQEQKNKLQEKLEELQWRLTSEAKRKQQLEDQKVKSDTTISELSSNNDHLELQLSEIQLKYQELDKSNQSSQLQLSECLSKLEEQTQQLDHSSKLNKKLEKDLSDQHDSIEKLQSQFNETEQQLQQFKQQSEELSSKLSKTTQQLDFNKQEFDRLSQERDTDNTNNQLEIQQLKKANSTLEEDYFSLSGIRDNLERQVLELRDENQLIKERLDSLGQQSSQFQSGAALEKQQLEQLVQEQSEQLIKLSSEKLGSEEEAKKQINQLELELTDHKSKLQIQLQLTEQSNEKIKKLKGKLEEYQDEKKQLQQELERIKQSKQSVEDEKNSLITQLTTVKFESTQVSTNVSHQKEKITTLKSTIEELNKSIGKLQAEQKNKDDEIRKIQFELNDQKQQFTRQTKEFSDLQSQQSIDRQKSEITIHSLERTNETLKSDFERVQQSLKQQERDCQQYKDTINRLENEVKQLTQLKERFENEFFVAKEQNSNQTQESVYLKEVTTQMQQNQSRIERELEEKKQHITRIDDERDELKKQLTQLQQQHEQSSTQLLLAQNELERLRKKELKYKERGHETSKQQDQFNMEIQSLRITNNDQLKSLQDYEQEKKKLKDKLSSSKQEAQQQRESIIKMDAELSAIKQHSQWVENSFTDMKQRNQELIESSALYKQQLLQQTSTIDSTIKEKENEISKLQQQLETSNQQLHQLKEELNSMKQSNQLESTEQSKQLNQLIQENQQLKSVTNEISKQLDDAVFENQKINNTIKEQEIKSKRMSVELQQHIDEGKQQEIQQLQSTIAQLKQQQQSETDRLEKEIQQMKRERETQMKLVESTKLNYHMLEDRMELYRNVMEIIDYKETEWEKLARLAGCKELDTKLLSDFLLSCKLEHTSLGSQMWFHQIDYWCPYERDSSKGIFYGIIRSIVDFTIKNFDDVDLLSYLLACCSLTLFLYKKNLVKHLNGANSIMPIIPTLGDLEELNERLSHQSLTTSGKFSGGGGGGGIDFIDQLQQSTGITFGLIFKATTLKLSPLVDGAILNENYNKKLTSISASSFGSGSFGLGSNGVGSVLSIELITTYLSSIITIFQHRMVHFTLSQRFFNQVFCWIGALIMKGFMLRQTFCTETFATFVKTKIDFLTRWADDIGNVWVGDVANAFQQVREVINVLNIKDKEKIIDDKIRKQYCPTLNSNQLKQVLSLFSPGEFGGKRVSAKVIASICPPNKSSAGQSFVQDENKLNTIPIDSLHYLEIQDIKTLSLPLSIRQTIETEIINLKQQIACKK
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MPPRKSKSRDVKSTAPSPSPSIGQRRSSRAPRKEPAPAVEVVEEKDEVSSESEEVDAAEGLETRETDAGEAEQDEQVQEVAEKEHVKSNKGKEKMSMAERMAKIKELRMKMNQSAAQNRRDLVEDHQKAQVTAKELARLEKQRKLAQTLRLKAEAEENGEDIERKKNWEWTIEDNERWQAKLEEQKVKQDTHFHNAEDDAYKKYNRNLRATKADLVAYERQKEAALGLAPGTLVPARATSSSLAASSSKPGLTGAEDLYRGADTLVYGDNKPSEDAVDRVISKINKDIGKKKRTKKDDEDGEINYINERNKVFNKKISRYFDKYTKEIRANFERGTAL