lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MLSTKMPNPWIFFLLSAFCSVLGSFNMEPVRNPVLNRLDIPAQLNHHQQDLQLQDHKNIPDVIVEAGKPFIINLPSQTSMAEVTGRDGKPLPPWMVYDATSQTVRGQPASSDAGDWAVRVDGPAREVFTIRVRRQIMDDDDANEGSGSLIDDYSESDDVESDVNEEILSPDNRVVISPTTPLFNGPSVLATPVMEPIPSTKPKNKYPTNPANRMTAIEPTLNRKIEPTPVQVMEGTTVRVLDDYSNSSLFDRIEETQSSEETPPLTDDLEFLGPNSISDYDEETAKNSPIPPTVTMHIPKIPATAGKVFRFVIPVTTFSDPVDGSSANLHLELLSEDGKPLDGITWIGFNATKREIYGLPLADDIGKYSFLVQARNSANLTVTEGAEIQVRQHPSERAFHHQFTLQLEPEFSEDEETLPQVYWMLKTVAGLSRTVGDKEDFIVVRRINGTVKNGNAFTFTWSNESLPRTHCPEDEIHESFDLIYNRVADQVTDQLDTELAPQLSVTLGSVELDGICQPLPVNPPPSIPQKETKPSSKMNQAPTTRNQVDHLSAEVGVLFRYPVPADTFHDEEDGDTRMLKLSLQNMNRQPLDSRNWLQFDSPNQEFYGLPLDNDVGSEEYQLLCTDSSGAVESDGLVVVVKERSKKPEEQPLVEFSLTIDDNYDTLMGKASRKVRLIEALAQIFNDPNHSNIIIRSFTSGSTVVTWSNATLIGTECPPNSVIENLRRMLMDDEGKLTQRSTEILVAADFQPSSAQVSPLGNCVGQHTPTFAPGADDGKTEGVDGQSTDDAWSDDYLLTFIVPGIIITVMLLLAAVIACILYRRRRTGKLGLEERRSFVSKGIPIIFAEELEERPSGRHPAKAPVILKEEKPSQPPDYHKVRSSASPYASHKAAEQHDLLRTPSDDAEEEPNSLYQPPPPLSAGRDSSSRYSRPKATPAYRKPPPYVPP
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRYQIRSEYGLADPEVYRGADKDDPEALLEGVAMAGLVGILRQLGDLAEFAAELFHDLHEEVMATAARGHDLMIRVQQLEAELPSVEKTLLSQTNQLQFAYTVGYEWHANVRTDENLITQDNMPRFILDSYEECRGPPRLFLLDRFDVAGAGTCLKRYSDPSFFKTHLATSEMLRTEEIPRKKARRTKKKGWWTRNGETQEAGQGPHGNSSIVHTINIRSSENITIAGAKLKWQMNGSLYSSSKSGRSYMECVLETPSPMECKEVIESSITTNVGPHDRTSSAHYDEMHENIKKDSLYGSRPVGISKKTSIDVQEKVLTLPGSPKDGKGQTIESLPKSTGKIESSLGLGHAELLDTLLEKERKEEATESSLTLGHVEQLDALLEREREEEAMESSFTLGNQELLDALLERESKEEANGDGYVDAFIGNEKQETNHNGYEDVFLGIERKEENGGGYESDDVASELDNYMDALTTMESEMETDSEYRPKHDFERQELDSDTNEEHERLAGSLHSFSEMETESEYRPKHDFERQELDSDTNEEHEQRAGSLHSFSNENSLSSHDWETLLKKDSFSGLANVQEDHAPGLNSLDDNHKASEGMISSSGYYNPWFEAVKIEPDSFKGDQPVDQSCAMVVSPTEITDESSRSNAISAIEVSGTPVINQFSSGSVQLAPLSTETVVIESDSLHGDHTIEQSPATRVSPCETTAEISRSLYGTDAISAEISGSPVIDGVIASSVQLAMPLFIDTVHIEEDSFSGEHYIDQSPIIGVSPTDITDRSSISLSENNAIATSDLSETSATYEINTSSVELAMPHISEPPSDTGAIGEGDTSAGTAEDVSVESPTIKSMHSPRSMNGASEPQSYDFKIESEPEKCHDSVDEHLDSHQSLQNLDPSDLVSQSPSLTEDYAKSIDSEGGFSPIEAGPSGPYLEIISLQASYKVQGTHLPNKTCLELGMEDNVEELMTHTLTPVDMMPSQCSSTDVSMEAIVSENHAKVVGSEWGFSPMEDTFTQSTIVEETMMEPFIEGHEDEMISKSSSTKIVEAVLPIDGYKKSVDSVGGLAPLEAEPSDSTSPQIASPQASQIEIKEKIVPLVEAFEQNEENFENLMEKDFGAKGFVSSDVPEVRASESIDVEKFEKLEPHESDSLQPEKPSQESQPREQITMSLTPINFLQFSIDSTERNQEPVFEAPHKSEKDIPPSPPKHTQPEILPANDTRSEAVQQSSFLPLPNEEHIDLKFERLHLSGESGALDNSEKRFSKVSSEASSGYNFSQRAGYEHLPCDGSQIAATKDFENATVAYSSMIFTSCSSLDEVGSLSSQPNLDVTIPQKTPQEEYNEIGTSSQHWVNPRLNQHFLEFVLPDVKVLGAGVEEMPPLPPLPPLQWRTGNPQYNSLTSEREDEHIPNLSASPPSIAKSQLNSLTMEWEAEHIANPSASSLDLAKPQLNSLNLEGEVQLIPEHFASPADVAKPESKSMDLKGEVKHIPDLSASQQDIAKTWLNSQTLEGEIEPIPNLSASQSELAESKMNGGYLPLGFSVQRLKRGQQKDPLIEAVASHDRSKLKKVTERCESGNRQKVNERDVLLEQIRTKSFNLRPTVATRPNIQVPTTNINVAAILEKANAIRQAFAGSDEDDDGDNWSDT
The following text describes a protein:
Function:
May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development.
Subcellular Localization:
Nucleus.
Sequence:
MEELTAFVSKSFDQKVKEKKEAITYREVLESGPLRGAKEPGCVEPGRDDRSSPAVRAAGGGGGAGGGGGGGGGGGGGAGGGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPELKDRKDDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAALGL
The following text describes a protein:
Function:
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. Regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosome during mitotic prophase and metaphase.
Sequence:
MADGGASPAQQEGEMSAAGPGLRRERQHRGSGRPPSARDLQLALAELYEDEAKRQSLRSDKPTTTKMSNSKGLKIDSFRSLRKPERSMSDDKENQRFYSGDSEYRGLQIWGASNNPSKIVAELFKEAKEHGAVPLDEASRTSGDFSKAKSFSGGGYRLGDSSQKHSEYIYGENQDVQILLKLWRNGFSLDDGELRSYSDPINAQFLESVKRGEIPVDLQRLVHGGQVNLDMEDHQEQEYVKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAPVLIDDSVPATKIQIRLADGSRLIQRFNQTHRIKDIRDFIIQSRPAFATTDFVLVTTFPNKELTDESLTLREADILNTVILQQLK
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MIVLEWLFLTIAPCDAAEPWQLGSQDAATPIMQGITDLHHDVFFFVILILVFVSWILGRDLWHFHYKKNPIPQRIVHGTTIEILRTIFPSIIPMFIAIPSFALLYSMDELLDINGIGVRLFTRVIKVQRNALKLNRVREASGLPVISHSHRRETLITIACQKRGVEVVRPIPRNAPSIGAYGSILVVAGEDDLELGQSCLLEVDNRVVLPAKSPIRFIVTSADVPHSWAVPSLRVKCDAVPGRLNQTSILVQREGVYYGQCSEICGTNHAYMPIVVEAVPRKDYGSRVSNQLIPQSPDKEPKALTESWGGPARRTEIDLNNLPIPDADTCRVELESRLMYSHRGSYMGEDLTSIVDKQLEIEKVVFSELLRKDYSLESLVAKRNEIRDLLFSPYGNALSEKTHALHLRQIFWEGAAQSLCFQREYCRPLRAIAKPSRIKASSSYSNSKRPTYSLSTGQSISVGVLLPKKRSQPNMGNDRQTKDLRSPCVLALCTGIAEFESACSDEWLLASPPPIRVVSVPAPSFFDEMDAERLGRRDFAKDGLSVREEGLFPFSFHCLTRFALQGREGIRAGRKGRRSSYGHKEAVTGLLKLKTELSFSLTTSEAQSSTSNTMRAGTGNRTIAVVDRGPDLDVERSSQAEAEKKAYDSVGVNMTCVKNQRKVRKLANSMFPYPSGQINGTGHGIHRQESRFDRADQMSEIFLKRKRCANLRTCFICGFDTIAIQVYLLSCLCGISKAKPRLCTEKDRR
The following text describes a protein:
Function:
Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 mediates repression of the HM loci and telomeres by recruiting the SIR complex. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.
Miscellaneous:
MISCELLANEOUS: Present with 4390 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSSPDDFETAPAEYVDALDPSMVVVDSGSAAVTAPSDSAAEVKANQNEENTGATAAETSEKVDQTEVEKKDDDDTTEVGVTTTTPSIADTAATANIASTSGASVTEPTTDDTAADEKKEQVSGPPLSNMKFYLNRDADAHDSLNDIDQLARLIRANGGEVLDSKPRESKENVFIVSPYNHTNLPTVTPTYIKACCQSNSLLNMENYLVPYDNFREVVDSRLQEESHSNGVDNSNSNSDNKDSIRPKTEIISTNTNGATEDSTSEKVMVDAEQQARLQEQAQLLRQHVSSTASITSGGHNDLVQIEQPQKDTSNNNNSNVNDEDNDLLTQDNNPQTADEGNASFQAQRSMISRGALPSHNKASFTDEEDEFILDVVRKNPTRRTTHTLYDEISHYVPNHTGNSIRHRFRVYLSKRLEYVYEVDKFGKLVRDDDGNLIKTKVLPPSIKRKFSADEDYTLAIAVKKQFYRDLFQIDPDTGRSLITDEDTPTAIARRNMTMDPNHVPGSEPNFAAYRTQSRRGPIAREFFKHFAEEHAAHTENAWRDRFRKFLLAYGIDDYISYYEAEKAQNREPEPMKNLTNRPKRPGVPTPGNYNSAAKRARNYSSQRNVQPTANAASANAAAAAAAAASNSYAIPENELLDEDTMNFISSLKNDLSNISNSLPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPPPNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFEKDLL
The following text describes a protein:
Function:
Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Binds E-box via C2H2-type zinc finger domain.
Sequence:
MPRSFLVKTHSSHRVPNYRRLETQREINGACSACGGLVVPLLPRDKEAPSVPGDLPQPWDRSSAVACISLPLLPRIEEALGASGLDALEVSEVDPRASRAAIVPLKDSLNHLNLPPLLVLPTRWSPTLGPDRHGAPEKLLGAERMPRAPGGFECFHCHKPYHTLAGLARHRQLHCHLQVGRVFTCKYCDKEYTSLGALKMHIRTHTLPCTCKICGKAFSRPWLLQGHVRTHTGEKPYACSHCSRAFADRSNLRAHLQTHSDAKKYRCRRCTKTFSRMSLLARHEESGCCPGP
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLENEAFLTALNKLYQTSTKKGTVWTTMKRYVDSDSNFQKKKADRINPETTEEEIKCLVRSTNGKKKISTIVLLKDIPSFEKSYKNVLLLNLDNLKAVPKEKKKQINTQVTAATKKKTN
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSDQKMNQYEKLKKQLKDNINKKKTHDKNLNSLEEQIFTLEGAYLEETSHGNLVKGFDTYIKGAQSKKRYVFNEDDRLFSLSSAVFLKHQAKTGAGGDLDETKNERKKTASQKRRKGDSTPMSGDEKPSKRSRVD
The following text describes a protein:
Function:
Putative oxidoreductase.
Sequence:
MAAPEALTFDNQVVVITGASSGIGADMARQLAEYANVTLVLAARRQEKLVAVAEDCKSINQQTKVDTVSYDAADPAAGSALVEGVLKRFGRIDTLILNAGIAGPWAEFETLPQDLRSLHRVMDVNYWGYVYAAHAAIPALKASRGRLAAVSSFYGRIPAPYQAGYSATKHAMQGFFNTLRPELARHDVSVTLHLPGGIATEVQQKFETADSKRVNLLMPDAFLAPSPKCAASVLSATLWRQAEAYYPFYALAASEFRQAAKDLFDRGFSELVKYYMDQGFFQLQ
The following text describes a protein:
Function:
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
Sequence:
MKTADCHISPVSGLTGESWRITGPGIDWLAREQSPHKSQLGVNRRRERKFLQHIAGNGLSPAVIAANQRWLVVNWLEGDVVTNEQFIPLVNHGQLARLLARLHHLPASGYRLDLRAQIARYGALIDPTRRSPGGVRLQHDFLRRPLPAITKIAPLHMDIHPGNLLTTPVGLKLIDWEYAADGDIALEIAALFRGNHWSMLQQQAFLQDYCNNEHGYHDIARLSRQIQQWLPWVDYLMLMWFEVRWQQTADPIFLAWAAPLRQRFNLSF
The following text describes a protein:
Function:
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Note=Cell periphery. The polarization of EXO84 requires actin cables (By similarity).
Sequence:
MPDNPSSFEDEFMKSNHLSVASESIPNESQRQSPTRLRVGTSKTDDIYRQKRQTKHIISQNEVFLQPKFFDNQNFDAQSYLNDVLQDLSEDEFVSLYNKLLRIHMGVRKNLEKNFYKNLNEYVFISGEVESMTSDFKKFQSLLKTLETDIEGLNLVDHTHDPSDESIKQTVQRLRSSIEGLDEAFWEAPQRQLICEQYNWMLINIDNQRPKLLVNMLLFNDRLLVTTSHMKEVDFPAKQQVLYNWNLTEISISSIETYGPAGAEMLQKEKEVSLYKLSINHNNKTTLLAVHNSEERDYMVRQARHHQLQELENWSRKHDEDLEFSRELEYHTKSEQADMCSYTSFQVLCKNLDTQDILQAYAKQRNMVKEISMQFDHLDIQISLQEFTDAIRNLALIQNKLERGNLNELFAEFFADKLHNRKRKVTEILLHQLGFKGISLSHGKEIVRYLRSLGHEKEGQGVFMKSRTLLIKEKCLNVQLEKDTPNFIDACAFIVFRCLAQTTSSYLQLFELKKLDPAYRNWIFQQIEALVDLIENQYKHLAHDRSYTDAVSKIMTYNTELKEAKIDAMPILQRLFDVHSKDLK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MRISLNKYKIFSNAKINIGLNVFQKESDGYHNIDSIMAPIDLSDEMDVTFYSDLGDLKIECSDKSIPTDERNILYKTYKIFFEESKKEKEKIDIILKKNIPSEAGLGGGSSNAGFFLKLLNKHYGNVYNEKELEKLAMRVGSDVPFFIKNKTARVGGKGNRVDLVENNLKDSIILIKPLDFGVSTKEAYESFDNLKEVKYADFDKIIKNLKEGNRIALESNIENSLEQGILETDTNIKMLKMTLNSVVSGKKFFMSGSGSTYYTFVTELEKSQIETRLKTFVDNVKIIICKTIN
The following text describes a protein:
Function:
Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).
Sequence:
MDPEACPCPTGGSCTCSDSCKCEGCTCASSKKSCCPAECEKCAKDCVCKGGEGAEAEEKKCGCCQ
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
Subcellular Localization:
Mitochondrion matrix. Nucleus.
Sequence:
MPKEPTAAKELRAQRVKAKGAPKPRPSEITLCVLGNGGPGNPRSLYVITDQARYMFNCGEGTQRLAHEHKMKLSKLENIFFTHNAWGNLGGLPGLALTVQDIGVPELRLHGPTDVEQLFDMTRGFMVTDRLTIAKRSPSDGPFSDHCMEVQYVPLFPQVTSEKACKKGKCDVDCASVVAYICKPHSKPGQLHLGKCVDLGVPPGPLLGELKNGRDVTLPNGTLIKSSDVVSPDEPGPVFIVVEVPSEEYLDPLLENAAFASHQATAAREQDAARVVVHFSPPSVMERPAYLDWITRFPASTVHLALNEYAGTLSSAAVHRAQHRLHLLSSSIFPLLHVEEASGVPKDLRDANVQAAETLTKFRLRPNLGLQKDAVVALDPAAYVQEAWASPGFSERLQELKAASAAKSQDSAAASSYPEIVFLGTASAIPGKDRNVSAVLVNLREDLCILLDCGEGTLNQLVRFYGLSRVNKVLATLGCILVSHLHADHHLGLIALLRARQSALEALGLPKEPVPVAAPRFMVPWTSRCDRSFEPVSHLFMFVDNASLLWDQPSPAEERSDLIRRLKLKDLSSVLVKHCKHAYGFTLTTEAGWKLTYSGDTLPCEDLVRAGTGSDILIHEATMEDDLAEEALLKTHSTTSQAIDVGSRMGARFTLLTHFSQRYAKLPLVSDRFHASVGCAFDHMLFAFGNFV
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKKVKVGKKRKDKFYKLAKETGYRARSAFKLIQLNRKFQFLETSRVLVDLCAAPGGWLQVASRFMPISSLIVGVDLVTIKPIPNVITLTGDITTDACKQAIKKELHTWKADSVLHDGAPNVGQAWVQDAFSQAQLTLSALRLACQLLKRGGCFITKVFRSKDYYSLMWVFQQLFKKVHATKPQGFLAPDKIDPKFLDSKHIFKDIETETKQNKINLMFSEKRKDRNRAGYPDNKHTLFTSTPVTDFITSENYLDHLASSNTLTFDEDSLIIAKHPLTTEEIKTYCQDIKVLGRKEIRTLIKWRSDIRDFYEQKATASETKKTENDESAGVESDDDEDAAKKKIEEFENEEASERKSHLLIHIQNMMMIKRQRRKRMQLKRKARERQLLKMKVPDSGINLSEDNSLFSLSTITDPKKLSNVNSGEMMLGDDEDEDKTEAMNLDSKNDTESDFDSNDSYSDDDDEESRSDTNHSDNITKTIGDKKSSNPLIIEMPEERSLKQKTNMWFSKNIFKEMDNDQDEELDFQQSISNLKGDKYNSWKEDPKMDSNYRNKSNGSPSKGESLSDTTTTNVRKVVKSDDDDSDESDSDSDYDYYQGMKNNTKTINNDSSQLITRNDFEIAPVENTIAPKYLSPEGLAIGALAATSKKRKEEFIDSAYNRYTFNDENLPDWFTEYEKKHYQKQIPLTKEEIQEQKKKLQEINARPIKKVAEAKARKKMKTLRKVERMRKKAEAILDTSDATDREKMLQIKSIYKKAGVGKAKKSEKQYVVGRKNLGKKRPPGVKGRYKMVDKRLKKDKRASNKKNRK
The following text describes a protein:
Function:
Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite animals), it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2.
Sequence:
MVPDDVEPMEVDDDGALIVDLNETVEEDEETKKEKKRRKRFREKLKRFDHYSQFSGISIAQIDWPLIQGRSLQRSPLTGQSFNADENIFRIDEWPRETFLQITSTLTFCAGAALLSNEKITLFVFQRTMKTLVAYCNFMYHRAITHNRRQINRIDVHELISRNPLRFHMFLQKFLPHPDINRTHFNNEFLYYFHNLYFQDETCRLLYHDVARYSPIINQQGTRMSLQHQIYYPDVMRNPAFDALWFTSFINPSGYSFSRFHAYRFHEALGMPPLESELIIVLDWLAKLIICDIGYKVLAWRDARGFQGLPDLLSFQMAMLEEGDPLFDLDIDYTAPPTRLFSEPTRFQTYPKFQPRRRIDFPSRFDGFYKKRRLERGLEEIQESFIMNHFPTKPLRTVYVYTHPEERRR
The following text describes a protein:
Function:
Involved in the fermentation of nicotinate to ammonia, propionate, acetate and carbon dioxide.
Sequence:
MQEKTKRIIKEDIEAVRAYSDCFDVEMPDLDENGEVIGLPAPYPREVAGTVRSGYRIYDLAKKAKERGWPIQNPILGRNTAEETYGESQEMYAYADKFDETLFHFVHAEATRHIDPLKGRELINQSRGKGGITPIGEREFIAMGGGSKHPVRINATGDTPHLSIINALIAGFDGTDIGPVIHVHFGGRGIHDYKTKVVNGYKAIQICAENNIFVQLDSHKHLNNIGGTDGMALAMCLLSEGLAVHAGLPWELSAIQMNVAGINIYADLAVMRAFRKACHSKSIIAVPETFQNPPGNLVAEAAHFSRMAVTAKLGGADFYRPKAAESVGIPTGDSMGQAIWGTEDVFGHVVNPDIQSPVIDAREAEIIDEALAVLEATLHLEGLTLEAMTDDFWKQWSDEALIDLIVAAGKAGVLDSQRAAGWDLKRHVVVNRDKDGITRYVKGYTPLGVDASRCAQSDEDVEVHVEKAPTRPEKIVLATVGADAHVNGINVIREAFQDAGYDVVYLRGMNLPESVAEVAAEVGADAVGVSNLLGLGMELFPRVSKRLEELGLRDKMVVCAGGRIAEKEEEHRQFEEKIQKEGSAFMGMDGFFGPGSSPEDCVKIIGDMINAKKA
The following text describes a protein:
Function:
Potential transporter for phosphate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSDNAKHHRDGHLVASGLQDRAARTPQHEGFLGPDRPWHLSFSLLLAGSFVLFSWWAFDYAGSGANKVILVLATVVGMFMAFNVGGNDVANSFGTSVGAGTLTMKQALLVAAIFEVSGAVIAGGDVTETIRSGIVDLSGVSVDPRDFMNIMLSALSAAALWLLFANRMGYPVSTTHSIIGGIVGAAIALGMVSGQGGAALRMVQWDQIGQIVVSWVLSPVLGGLVSYLLYGVIKRHILLYNEQAERRLTEIKKERIAHRERHKAAFDRLTEIQQIAYTGALARDAVAANRKDFDPDELESDYYRELHEIDAKTSSVDAFRALQNWVPLVAAAGSMIIVAMLLFKGFKHMHLGLTTMNNYFIIAMVGAAVWMATFIFAKTLRGESLSRSTFLMFSWMQVFTASGFAFSHGSNDIANAIGPFAAILDVLRTGAIEGNAAVPAAAMVTFGVALCAGLWFIGRRVIATVGHNLTTMHPASGFAAELSAAGVVMGATVLGLPVSSTHILIGAVLGVGIVNRSTNWGLMKPIVLAWVITLPSAAILASVGLVALRAIF
The following text describes a protein:
Function:
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Postsynaptic density.
Sequence:
MIVDATETSREIEAENFSGEDEVIGISFALLLIRRLQRKPSSCQDFWGDCAVIGVCSPFPFLAMSGMGRVSWWCLTLSRVCLLIPCALVLARVPGSSSHPQPCQILKRIGHTVRIGAVQLQPWRTRGITTQFSRVWPDIDTGLHKIGAGRDQDTDGAEGMDGESKLRDKAKRELAGPTLERNTNHGPRSFIGYRGRGDLLFPRDALLLAVENLNRVPGLLPYNLSLEVVMAIEAGLGDLPILPFSASSSSWSSDPLSFLQSVCHTVVVQGVSAILAFPQNKGEMLELEFISSTLHIPVVSIVRSEFSRRSENPLHLQLSIENALTSNAEVTYSILTMNSWYNYSILLCQEDWNITDFLMLTQNNSKFHLGLILNMTVNLTLSNYVISYLQLNLDSIKDTTSTIVMFGCDMEDTRRIFEMATLYGIMLPDFHWIFGDSQNVEELRTEGLPLGLIAHGKTTESYFEHYVQDAMELIARAVATATMDRPELALIPSTTNCMSASSTNLTSGQYLSRFLNNTTFSGVSGHIKVKEYSIINSENHYFIWNLQHDPVGNPMWTRLGSWQDRKIIMDYPLWPDQAQRHKSHYQQPARLHLRVVTLIEHPFVFTRNVDDDGQCPAGQLCLDPMTNDSKVLDSLFESLQGGNDSVPIEFKKCCYGYCIDLLEKLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGAAHLAVTSFSINTARSQVIDFTSPFFSTSLGILVRTKDTAAPIGAFMWPLHWTMWLGIFVSLHITAIFLTLYEWKSPFGLTPNGRNRSKVFSFSSALNVCYAILFGRTAAIKTPKCWTGRFLMNLWAIFCLFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVKKSFPEMHEYMRRYNAPSTSEGVTFLKNDPEALDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELVSQYKSSGFMDSLHDKWYKVVPCGKRSFAVTETLQMGITHFSGLFVMLCIGFGLSILTTIGEHIVFRLVLPRIKKKSKLKYWLHTSQRLHRALNTSFNEEKFQQKLKRLEKRCNAGNSQQRVWNTSNQASCNRRKYIYKEAHNELSFRHQQDLPLPQLRRETPKLLTTNGKAESLNISRNSVVKELSELEKQIQVIKQELQIAMNRKHELEEYQKTKRTSES
The following text describes a protein:
Function:
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MRIDIGAALDATATPGVPPDALDRLDDRVAHAHDRITAGMDGDEFGYAALNLPRTVDVDAITAAADAVADADTLVTVGIGGSALGAATLVDALGDDDLDYHALDNVDPAHVTRLLDRIDLSTSAVHVVSRSGTTAETLANFLVVRDAMDDAGVDWTARTLVTTGDDGPLRALADTHDLPVLDAPRGVPGRFAALSTVALPAAAIAGVDVGELVAGAADGRAALAGSLEDCSAYAYGATAYALDQRGAGVNAMLPYAERLETFAEWFAQLWAESLGKDGVGQTPARALGATDQHSQLQLYRAGPRDKLVTMLRPASRPDCAIPEAELADIDYLTGGDLGALLDAEFEATAASLAASGVPTVRVEVPAVDARSVGRLLFDFEAACVLAGELYGVETFTQPAVEWGKNAARELLRGEDPLPETETHIVE
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MQAAAIAAMAAHAILTAMPPILHLPLSPLPPNHSSFHGVSLNPPRQSFSLSLAAKKQPPLFVVASATKKAVAVLKGTSNVEGVVILTQEADGPTTVNARITGLTPGPHGFHLHQYGDTTNGCVSTGAHFNPNNLTHGAPEDEIRHAGDLGNIVATADGVAEAIIVDNQIPLSGPNTVIGRALVVHELEDDLGKGRHELSSTTGNAGGRLACGVVGLTPV
The following text describes a protein:
Function:
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.
Subcellular Localization:
Nucleus.
Sequence:
MTPVVNLRSKRLADPEVTCFAPITTVVSKPLISGKALPSILERINRGDWDVADEYDPQRPNEYEKLKEKSNGSDKNRAGVSDREDRDDKEKDRKRGRVGRREFYRDEVSAPNLKLSGFGHRQNDDDMYLPSPGLVAKQGGATIAPPPSLQEMSIDSGCEATNTMPYSASSVAAKIMAKYGFKDGQGLGKSEQGMAIALQVEKTSKRGGRIIHEKDVFLPPLALSPPSIGSQIGTSPSHKAMPPPQMVDTAAESGDIGYSITEIMKSPSKVVLLRNMVGPGDVDEELEPEVKDECNTKYGEVNSVIIHESFGTVPEDAVKIFVEFRRIESAIKAVVDLNGRFFGGRQVRAGFYNYDKFKCFQLH
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MDFSLKYPEIGDEFDPRYHVLIPSKQDVQDRSDNPHWNSYEEIFRDNFPVRKFEVQEIPGKGRGLICTDKIYQGEMVFKEKASVFYEGPEEDDDMKDSTYYMVKSIYFGTAFCTVPLAIQLGQNPDRVEEFNEHVDFIYQDLLKDDLLEYPVKREDIAKIVNGIHTNSFALDFLDGYALFMACSLCNHSCRENMGWHTVGDTMYWTALQDIEIGTELTISYTFPSILPHRLKYFKENYGFFCDCPLCSGPSDPWRAFKCNCGGRIYQEPNGWICHQCHKICTQEEINEFINEETAFKKLKKSKRIQHFYNKTRKMDNSHIYMFKTLRSFVFDEKCPNPLILFEDCLVPIAKYQSSLCHSRLYSAILEQFGVALLKYAKKYPFQSQFCQDKAKKMFKTAYDYRCSLGMGITGYAAQEYIECLELFDEHKLEKYTEYVEY
The following text describes a protein:
Function:
Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation. Interacts with REPTOR to form a transcriptional activator complex that functions downstream of TORC1 to up-regulate the expression of most target genes induced by TORC1 inhibition. In the complex, acts as the transcriptional activator. Under normal conditions TORC1 is active, inhibiting the formation of the REPTOR/REPTOR-BP complex by phosphorylating REPTOR and mediates its cytoplasmic retention by forming a docking site for 14-3-3 proteins. Upon TORC1 inhibition resulting from nutrient stress, REPTOR is recruited into the nucleus where it interacts with REPTOR-BP and together they maintain organismal metabolism by activating the expression of target stress response genes including those involved in glycogenesis and triglyceride biosynthesis. The complex also appears to negatively regulate some aspects of TORC1-dependent larval growth.
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=Translocation from the cytoplasm to the nucleus is promoted by dephosphorylation and inhibited by phosphorylation. Binds to chromatin.
Sequence:
MTENQLYPMSSEFFDTGSNSSSNTLKYDLYSLGSTVVGAALPTLTINTGYGSSSSNNNNTNNNNNNSSSHSSSSNCSTSTTNTCNVMLSTTAITIPRSSNHNQIHHHPYQQSDLQTPRHHPSPLHTLPSMTHQQNQLQQQQQQQHHNQQQQLQQSHLALGELSDFGLDALDAASLSPTLLQDVSLSAVSPLSTTLYNGNTSGAGSSNGIGSGSGGYFTPDMSHSLSLNVVSEQVLLQEATTPNELLYEMTPNSNAMWSDISSAIIHTKHEPFSLDDDYIFPNDKAEIQAADLSDLNGGDFLDVIGNIEDFLPQTAVTQSVNFLLSPQAQGQDALVAPPMELLQQQQQNHQQLQVGSLPQLQTLLTLSQQQQSNSSSTSPYEIYHSTPQKPQQQQLSASFSPGSQASQSPLTPPPPPHANRPQYQMVKSRNMQELIKKGFPMSSPPERSILSQSAALSPGGSSGFGSSASGNSTTTSNQTSGSAVRKSFGYQSAVENSQLSRLSSSAPTHLGLEHIWMRREPRQHLLSTGSLAEAESFSSLSTGSVLSPDGIDFSQDDEDDNSSENSDNYDDCSSDNGLSEDEDETRTSTPNHLSSSKGKERFFWQYNVQAKGPKGKRLVFQSKLEDPHVLNEVTDPVFSPTCSVRGIKVYKHSGKARKGDGNDLTPNARKLHNIGKELDKLSRTINDMTPVSELPFNVRPKSRKEKNKLASRACRLKKKAQHEANKIKLFGLEIEHSEFNVKAVEISYNPSIFVL