lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Pore-forming subunit of a mechanosensitive non-specific cation channel, that conducts both sodium and potassium ions.
Miscellaneous:
MISCELLANEOUS: Piezo comes from the Greek 'piesi' meaning pressure.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASFLVGFLLPSLLLAAALINWSVISFLDLIAFLLVHYIAPEIGYRFQRRHWLLWPIFIFSFAVFLAQVVYLVIWAALGQDWDTPDTGWMRVIGFMILKSWRNPTVMYFLALQLLTSLVALADIYSSRFGFARWRDTWWSHFSGIFEHLGSHLRVASCLLLPAVQLAVGICNPSWVSLPFFIGSCAGLVDWSLTSNVSGLFRWWRVLYIYAGFNIVLLYLYQLPINFSDMIRWIASFIGLFRISLETEGPDICSGLFLVLFYIMLSYVRSDLEDMDFIMSTSENNLAERLLPPKYSFFIRESRAGVRHTNVLLRGAVFKTFSINFFTYGFPVSLFALSFWSFHFASLCAFGLLAYVGYIIYAFPSLFQLHRLNGLLLVFILLWAVSTYIFNVAFSFLNTKVGKFGLGMLVALGNLVNNSVFLYLSEESSRSSNERSYVEADEETKVLVVATIAWGLRKCSRAIMLALIFLIAMKPGFFHAVYVIFFLMYLLSHNINRKIRKSLILLCEVHFALLYILEIDLVSNSLKQEGSASREVLFQLGLLRSESSWDFLEIALLACFCAIHNHGFEVLFSFSAIVRHTPSPPIGFSILKAGLNKSVLLSVYSSPSSSYSQDNTTYERHIASFLSAIGQKFLSMYRSCGTYIAFITILISVYLVKPNYVSFGYIFLLLLWITGRQLFEETKRRLWFPLKAYAVLVFMFIYCLSSFVSLQLWLSGFIDLYFYLGYNSKAPLLDNVWESLAVLIVMQLYSYERRQSGHYIPGQSSLLHPGVFGFFERFLAWHGQKILFAALFYASLSPISVFGFVYLLGLVICTTFPKSSSIPSKSFLIYTGFLVSAEYLFQLWGMQAQMFPGQKYAELSFYLGLRVYEPGFWGIESGLRGKVLVVAACTLQYNVFRWLERTSGLTVIKGKYEEPCPLFVSAEDTTASVSSSNGENPSSTDHASISMKQGEATSNSWPFFSPRGNQGAGFLHPKTGGSESGSSRKFSFGHFWGSIKESHRWNRRRILALKKERFETQKNLLKIYLKFWIENMFNLYGLEINMIALLLASFALLNAISMVYIALLAACVLLRRRVIQKLWPVVVFLFASILAIEYVATWNSFLPSDQAPSETSVHCHDCWSIAALYFKFCRECWLGVRVDDPRTLISYFVVFMLACFKLRADHISSFSESSTYHQMKSQRKNSFVWRDLSFETKSMWTVLDYLRLYCYVHLLDVVLILILITGTLEYDILHLGYLAFALVFARMRLEILKKKNKIFRFLRVYNFVLIIFSLAYQSPFVGNFNDGKCETVDYIYEVIGFYKYDYGFRITARSALVEIIIFMLVSLQSYMFSSQEFDYVSRYLEAEQIGAIVREQEKKAARKTEQLQQIREAEEKKRQRNLQVEKMKSEMLNLRVQLHRMNSDSNFGVASPRTEGLRRRKSPYLIPDSGAASPEIDGVVHRKEEQPIDEDSQYPFEAHEFPVSTTPEALDSPEYSFGASPCEITEVQQDLDVMSMERERKQKSEGKENPLISAVQLIGDGVSQVQFIGNQAVNNLVNFLNISPENSDTNEQSSVDDEVYDEMESQKRKHTPFERSTSLQSDRSSDGTSFQIGRIFRHIWSRMQSNNDIVCYCCFIIAFLWNFSLLSMVYLAALFLYALCVHTGPTHIFWVIMLMYTEIYILLQYLYQIIIQHCGLSIDAPLLHELGFPTQRIKSSFVVSSLPLFLIYIFTLIQSSITVKDGDWVPSADFTSRRNARGSQKDLTRIRLSQRILDVFKKLRDSAKLVIRSIYRYWISLTRGAESPPYFVQVTMDVHMWPEDGIQPERVECRMNQLLRLVHNERCEKGNPDLCPYSSRVHVQSIERSTETPNEALVVLEVEYASPTNGCSSAEWYKSLTPASDVAKEIRKAQHSGLGEGTGFPYPILSVIGGGKRDTDLYAYIFGADLIVFFLVAIFYQSVIKNKSEFIDVYQLEDQFPFDFVIILMVIFFLIVVDRVIYLCSFATGKVVYYLFSLILFTYAVTEYAWSIYPTQQHAAGLALRIIFLAKAMSLALQAIQIRYGLPHKSTLYRQFLTSEVSRINYYGYRLYRALPFLYELRCVLDWSCTATSLTMYDWLKLEDVNASLYLVKCDTVLNRATHKHGEKQTKMTKCCNGICLFFILLCVIWAPMLMYSSGNPTNIANPIKDASVQIDLKTVGGKLTLYQTTLCERISGDNIDLGLDLGSQSFLPTYNKNDIQLICCQADASVLWLVPDTVVTRFIQSLDWDTDMDITFTWVLNRDRPKGKETVKYERSVDPLDLPKRSDIQMVLNGSMDGFRVHNLYPKFFRVTGSGDVRSFEDQTDEVSADILINHANFKWWWSFHNLKASENISACEGMDGPVAIIMSEETPPQGFLGDTLSKFSIWGLYITFVLAVGRFIRLQCSDLRMRIPYENLPSCDRLIAICEDLYAARAEGELGVEEVLYWTLVKIYRSPHMLLEYTKLDYDA
The following text describes a protein:
Function:
Member of a two-component regulatory system.
Subcellular Localization:
Cell inner membrane.
Sequence:
MPARRSLTLYAALLFAAVAALVVSAVGFYLYRSVEEAMLRRSDVMVAGRVEHFRNLLRDNLTLAELKARPRLFENMLGNEQDILLLGQPGEAPIVAVNPRHERLPSLRVVAAGQALNPSVVHAALTHDGIPMRVLAAEVLVGGREPLQITAAHLLLGETRMLAQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTRLDVAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSGQLRADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFPAQD
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
Subcellular Localization:
Nucleus.
Sequence:
MTTSHPNRSHLEIANSLKKQLVTSLTASNEKEIKECLERIKKEVHPSEELIRATKIGITVGKQRQNSNPEIAKIAKSIINQWKSHMKKEPTPSQSSSSKNGTTTSASSNSNHNPKSPSLSSSQHSNMKSPRPDQAAKLTNLSTTTSPEKPTTTTTTTTTTATTSATNSNNPATGPSATTVGSSQPKTTPQFSPNSNGTKIKRNGPRSSKTEDPSLNFELYKDEKVRNGSLKAVFDALIFDSDAPADLIYERAKAIETEVNKTHDSNGYKIKMRSLIFNLRDKNNPGLRESVVSGEISASRLCVMGPQDMASEERKAQDRKLAEENLFKARGAGPQQAETDAFRCARCGQRKCTYYQMQTRSADEPMTTFVTCVNCNCRWKFS
The following text describes a protein:
Function:
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Subcellular Localization:
Cytoplasm. Endosome. Nucleus.
Sequence:
MSGVPLSPEAPGVERVSRAPSSPRSPARRCLFGPVDHELLARDLERSLRAMENEKSERWNFDFRNHRPLPGPLHWEETEKAPEFYRRGQDSQSQWAEGQAEPRAKKRNGETADSSAPSMKKSHRKEAEDTAGGSLTPPPEETPKKSKPGT
The following text describes a protein:
Function:
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Sequence:
MIQKEAPKVKDDKNIKNVIAVMSGKGGVGKSTVTTLLAKELRKKGYSVGVMDADITGPSIPRLMGVSEQKMTSDGKNMYPVVTEDGIEIVSINLMIDENEPVVWRGPVIAGAVMQFWNEVVWGNLDYLLIDMPPGTGDVPLTVMKSFNIKGLIMVSVPQDMVSMIVTKAIKMARKLNMNIIGLIENMSYITCDCCNNKIYLTDENDTQTFLKENDVELLGELPMTKQIAKLTKGESEYPEETFSKIADRVMEKVKEL
The following text describes a protein:
Function:
Localizes protein arginine N-methyltransferase PRMT3 to the nucleus.
Subcellular Localization:
Nucleus.
Sequence:
MMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDVSSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPEELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGSNPEGEDPEREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNLLVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLCGKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPKNEEFVLHLQSHEAERPYGCKKCGRRFGRLSNCTRHEKTHSACKTRKQK
The following text describes a protein:
Function:
Required for methylation of the 3' adenosines in the small subunit of plastid rRNA. Essential for chloroplast biogenesis at low temperatures.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MMNAVITSATINCNSLSPSWTCGDNSPSKLLLGEISAALSRRRTVKVSCGKSSPDDYHSTLKSLNSRGRFPRKSLGQHYMLNSDINDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHIRSHMLSILETRRLSHPDSALAKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLVEPALRTSEYRPINILINFYSEPEYNFRVPRENFFPQPKVDAAVVTFKLKHPRDYPDVSSTKNFFSLVNSAFNGKRKMLRKSLQHISSSPDIEKALGVAGLPATSRPEELTLDDFVKLHNVIARE
The following text describes a protein:
Function:
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVWRRHCSALPFIGRMRPVSVIITSWINQEGMLCEGLGWPSLPWCLTSTMCPAQDVRTVGLTLNLSLLHGKTVSCRDITGQLKIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVLFQGTDHIDQWNKVIEQLGTPSADFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDRRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSRSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSSLEFTGIFTENGGVLTPGTLKVEDTSAIFKSDKAGKTIKLSPGDIKDIRWQKLGNRPGIRFGLKDGGSHRFGGFKEADFGKILVVTESSWGLGIEKTNLVIKGWNYGNVQVKGKNVEFSWENNPIFEIPCTNVSQCVANKNEAVLEFHQHENNPISLMEMRFHMPVDPENEDDIDRVEEFKQAVLAYAGLEAETEQPITLLSDILCTTPRGRYDIKVYPTSIALHGKTYDYKIPVKTITRLFLVPHKDGRHVYFVLALNPPIRQGQTRYTYLVFEFVKDDDQEMEIALTDDLKEKYGGQLKSEMDGPLYENVSILFKVVCNLKVTVPGRFIGSSGTPAIQCSHKQNPGLLYPLEKGFLFIHKPVMYIRLEEISSCHFARSDAGTVTRTFDFEIDMKSGQSVMFNAMEKEENHKLFDYLNKKEIKIRNSQRLEKNQHVDSSDDEIDPYTNTVKAEGRGREESDDDESTDEDYDLDKDIKNQKKDRDSSEGSGSEPDDEYDSGSEKDSSGTGESEPDDENVRPKKKSEVNSEKKSKKEKPEKVGKKRKGKKEKDPNEPKRAATAYFLWFNANRASLKEDGDTVPEVAKKGGAKWKEMSADDKKEWEQKAAQDKIRYENEMKEYKKNGGGSSSVTSNPPKKGTSSPSKYKSKEHISDSDDSDDDEPPKQKKSSKEATPTDESDMASDNSD
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import. Binds RNA polymerase II in the active center cleft between the two largest subunits in the cytoplasm. Then uses an N-terminal bipartite nuclear localization signal that may be recognized by karyopherin alpha to direct the polymerase II complex nuclear import. In the nucleus, is displaced from polymerase II complex by transcription initiation factors and nucleic acids, enabling its export and recycling.
Miscellaneous:
MISCELLANEOUS: Present with 1080 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm.
Sequence:
MSTISTTTAPEFIRVKRRRDEDSVQALLIDEGKRVKKQKFIFKLSKTVSSESYQSEQESSTPLLKLAHEDHRHFVLEQRKKSRRDSDDEKSQQRLAAEGSTVDDDGLPPEINQMVNDYLKLNKGVEKTERKKPSRKYFTGDSAKIASLPSLDYVFDIYHLEKIHDDEVARYNNEKNIGFVKIIEHIDLALDEESDPNEARSDDEDSNDENYYQNDYPEDEDDDRSILFGSEGEDIAALGEEIVIGVNKSRFSSWNDDKIQGSNGYHDVEEEYGDLFNRLGGKSDVLKSINSSNFIDLDGQEGEIEISDNEDDSDEGDDIEYPRNEFFPTDVDDPLAHHRDRIFHQLQKKINRS
The following text describes a protein:
Function:
This is a receptor for the anterior pituitary hormone prolactin.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MKENVPSTVVFILLLFLNISLLNGQSPPGKPEIFKCRSPEKETFTCWWKPGADGGLPTNYTLTYHKEGETFTHECPDYKTGGPNSCYFNKKHTSIWTIYIITVNATNQMGSSSSDPRYVDVTYIVEPDPPVNLTLELKKPEDQKPYLWIKWLPPTLVDVRSGWLTLQYEIRLQPEKTAEWETHFAGQQTQFKILSLYPGQKYLVQVRCKPDHGFWSEWSPESSIQIPNDFSMKDTTMWIFVAILSAVVCLIMIWAVALKGYSMVACILPPVPGPKIKGFDTHLLEKGKSEELLSALGCQDFPPTSDCEDLLVEFLEVDDSEDQQLMPAHSKEHPSQGRKPTHLDPDSDSGRGSCDSPSLLSEKCDEPRANPPKFHTPEGIEKPGDPETNLPRPQDPQSTSVESKLLYFHADGSKSSTWPLPQPPILHDPGSSYHNLADVGQLVLGTAGATAALLEKTDRHAFNPPKTTETGGEGRATEQKESESFHSKTDQGTVWLLPQDKGPFVSPKPMEYVEIHKVSKDGALALLPKQQENGDRPEKAGAPETSKEYAQVSRVMDNHILVLVQDPRARNVAPFEEPTKETPPSRPQNPAAKDLASFTTAPGHCRHPLGGLDYLDPAGFMHSFQ
The following text describes a protein:
Function:
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion.
Sequence:
MAAVDSFHLLYRQVAWSCQSHMEFLAVVGALYTAGKGLKLICQSYNLIRLHITPLLFSRTNLGRQYGAWAVVTGATSGIAQAYAEELARCGMNVVLVDNNREKLQKMSDSITATHGVNTSFIEVDFCKGHEAYRPIKDALRHVEVGILVNCVGNFLEYPQSVIECPEEQLWKIIHVSVSAATIMAKIVVPGMAQRRRGAIVNVSFRSCCKPNFPMTMYTPCQLYMDGFTKELQSELSSKGIFVQSLTPLCVAKERTLHYRPSFRFPFLVPSPEVYARHAVQMLGVSHRTTGYWAHSMQLAAACWLPDFICQLMGRFLHTASE
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MNFLGDPFKLIKPRFDDSGVDRLNYYYTPVVIIVMAVTITAKQYVGEPLQCWVPAQFSRAWEQYAENYCFVYNTYWVRPGEEIPSDVDERLAAQLIYYQWVPFIMIIEAGLFHFPAKIWAVLSKTSGLNLAGMIGAVVKAEEGNDESKLQSAALNVCHLLENSNKMRKLRTVGASRMGKYARLGELDGTYLSNVYLVAKLIYCINTVVQFTSLNKFLKQPDMFWGASVLNDLVHGHNWEDSGNFPRIAMCDFEVRTMGNVQRWKGPQHMTGLLTLIDSLAHFITMKMPSRRQRFVKRFITCPPEEKAVLEDFTKEYLNPDMFLILKMIDGHTSEIVTGNILQQLYDNFRNSTETLNDHPYLRHLDLARQESEFASEDPLSNDNTVQEAFLRTLQVPSPTENFEFRRLSMTRSPISR
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSNLAVLQESLGRSEKMKDNMLSILTTFEKRLKKLEDTIMPIYQETGNLQRRHENIEKTVAVLDHVIGYYNVAEDVEPVMRDGPSTNLALYIESLNRLTRAVKFLVHNNPGSPTMAHVIALYDAGKESLEKEFHNLLSQCNKPIQPIQLIESVSNEEDEKASSSSLSPRSSSASLSSTSLTSPYNIVYYNDEALNKLKVISIWLLESKYEVNLVQYYVKSSSSSSSSITSLKSHLRVVPIRENSATLIVGGGMSQSPSVKGKLRETPKKTLKRGVVTKASSFLKKQQDHAAYRPVNVGLKDENFEAESSLMTQLIPEKSRSRIYDHLLLITVDFLNREAEGCKALEEFVDSIRNDPDKSSMPKDGTVHELTSNAMFFMEQLLEYSDVVGCMLMFQAKVLSALGLNLSNKTECYNDVALRAIFMLNNFNYVLNLMKRSGMMDVIHLWNSEVQLFYEEQINNQKRLYSQCWSGVLHFISENQRPISTDLSPDSRLKDKDRNAIKEKFAGFNKELEDICRQQKSFSVPDPELKQALIDDNRSFVLPFYSAFLKKYRNVSFTKNPEKYMKYSEEDVARCIVGLFDASA
The following text describes a protein:
Function:
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Localizes to microtubule plus ends. Localizes preferentially to the ends of tyrosinated microtubules. Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (By similarity).
Domain:
Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.
Sequence:
MSMLKPSGLKAPTKILKPGSTALKTPAAAAAPLEKTVPSEKASGPPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTAHARAASPLSTAAATMVSSSPATPSNIPQKPSQPVAKETSATPQISNLTKTASESISNLSEAGSVKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAAAVRRVMATTPASLKRSPSASSLSSMSSVASSVSSKPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESSKPPGDVDMSLSLLQEISALQEKLEVTHTDHQNEVTSLKDHFGTREEMFQKEIKALHAATEKLSKENESLRSKLDHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGIGTDSAEFAELKTQIERLRLDYQHEIESLQSKQDSERSAHAKEMESMKAKLMKIIKEKEDSLEAVKARLDTAEDQHLVEMEEMLSKLQEAEIKKEKFASASEEAVSTQTSMQDTVNKLHQKEEQFNMLSSELEKLRENLTDMEAKFKEKDEREDQLVKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERSVEELQLKLTKANENASLLQKSIGEVTLKAEQSQQEAAKKHEEEKKELENKLLELEKKMETSHYQCQDLKAKYEKASSETKIKHEEILQNFQKMLVDTEDKLKAAQEANRDLMQDMEELKSQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQSELDTLKENNLKTVEELNKSKELLNEENQKMEEFKKEIETLKQAAAQKSQQLSALQEENVKLAEELGRTRDEVTSHQKLEEERSVLNNQLLEMKKSLPSNTLRESEYRKDADEEKASLQKSISLTSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDVQTEEDERAQESQQMIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGEDPNSYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRSEERPYCEICEMFGHWATNCNDDETF
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MILNCLKLKVGLMKFERKRMGGHVRGRENEGRYSDFFEGEEWVITETGAGMMSYKNKAARATAEGRIGSYIHDSRIGVLVEVNCKTGFLSRGEIFKQLVDYIAMRVAACPHVETLSPKTFLRNSIDKVTGKDMVKLIIATIGENMKVTRFVRFNLRERGFAKENRLRMNDMYATCVGVGCGQKFGEKKWKCLMQVVNCLMLCYKQSTVVVSDSLDKQLREETGAGMMDCKKAHAETEGDLEKVKAYLRKKGLSFADKKSRRLAAEGRIGTYIHDSCIVAAILQVQFVSIEDILKTIVAKEKELKMQREDLALKPENIREKIVEGRISKRLGGLSLIEQPFIKDDSVSLKDLERQSIAVRLLI
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Subcellular Localization:
Nucleus.
Sequence:
MFMNPNKPKIRTKTVTVKKPAPATAASSPRTPSTAQSRPALPINSRSFSGPPANRYKVTSSASASASAQTKPREPARRSLAVSHVQKRKVSPSTPQWASSDDESEEEDDRLGKRRKTRPASNSSEPMNLNRTLEPDLSRRIRIQEPETNGETNVTSDKTLENGASSGKKTGAKRGSLLQGMMMSRGDEAKNYKAAFTGCEKNPILELQYPSPTRPERFEAVHPLDAQEGYSPLEDIYFSIEEIIQHYLPTDLGNELSSDTEGTVRLLKRAVSKNSPDDFKTELAKFNALIKDKLSDGTIQRIMDEMHAIPLSLVKRITAQSYNRIVSPQAHRLRKVKGKETTYGELLTPFVHKIFAQTGLNSSHVFVDLGSGVGNVVLQAALQTGAESWGIEKMELAASLGSKQASEIQARARLWNIHLGAIHLISGDFLETPEIDEVLRRADVVLVNNKVFGEKLNNDLLQKFLDLKDGCKVVSLESFGGGAKQGVRHEQAIAGLFDEERFESGTFSVSWVGESVEYYIATKAR
The following text describes a protein:
Function:
Involved in the regulation of axillary shoot growth angle. Promotes horizontal shoot growth.
Sequence:
MKIFNWVHKRLHQRVVKDGFAGNVKKSELETNDKDTQAFLKQVGLVNVDGLDGWRDGILTIGTFGFDPLKPSTHQNEYFVLESEEDDQESHGFSHSGNDDDDDDDEHYDHSVEDEELNPLMFTTFEHSFEDIGSNFDAIVQKPADVILTVDGVPLTPFEGSSEISTKPDQSANDQSKNKKGQRITLADLFQADVPDVGQLKLDSGKVQPEMEKKMNARTRSGLAFAKKLIPRVKDDSSPIKNMQRLMRRMLKRKIHPAELEVKIHKSDGQKQPSAVELISNVENDAYESVSLLPIQGAPCVH
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MPRKVQTWDDYDSAVDQIILTPSDSDFIDQLIPVLKDATASGRTATLVQSLSQYAEEREGDIERIGLTQHEEFLGSVSQLQTIREETVALTAEILDLNQSIQASTEKLAEQKQALVDTRRVRQNITDVSDALRESLKIMHAVNNAHDLIRKKKYYGALKSLEDLQNEYLVPIIQNKYATQYRLADLIQKSIPASRKTISEAVMTDLNTWLYRIRETSQFLGEVAFFGTRQRLDRQRERAEQNPYLGHFKLNSAIELVFDESDEFDVLDNEEVQVDFTPLHEALHIHEALGQIDKFRAEYAATRRQQKELLMPSSVNLSSDEEENSLRDLLEQITGFAVIEKATIQRAPQLRSTVEVDELWDSMCQTAIRLISRSLTDVDNAELLLKIKGDIALFIQTMESWNYSVSTLNNFQLTLFYKYAELLKRRFSDDFQEIVSTDDYMPMQINNAEEYEKVLKVSWYTEEKAPEELTFPCVLPFSQMYPLCCIDIRNFLNQFYFFSNDHFQHPNIVDETLRKSLDELLTEKVCRTLVERLNSQYLGQIVQILINLEHFEEACHQLEQELIRARSSTSAGGPVSLKSTEEFRSNKKTAEKRIFELVNSKIDDLVDTSDYNWMTPSKPTEPSNYMQTLTRYLENIMGSTLLGLPREIKELIYFDALSHAANKILALPLSPDVKKINANAVAAMAMDVQHLSAFVANLENAPMLEQNLDELQQTIALMQSDNHDEFFDISTRNKKYGRVDAMNGPILLEKLTLGIESTTTSRAAAPLANFGSRFGLR
The following text describes a protein:
Function:
May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Subcellular Localization:
Nucleus.
Sequence:
MAEGKVEHVVVDSGAFIRNAPIRDIAENVYSLQGVVSEIRDKETRQRLEVLPYQIAFKEPSVENVRQVTEFSKKTGDYPSLSAVDIKVLALTLQLEKQHVGTEHIKTEPEKKPTYFATQKPLERVTDLPGWVVTTKQDKDAKNSTPLISEGQVEDEVVGKDTDKLNILQDGGQTATDEKQDVEITSNKSEVLDCLSEGTADNVSEVEGQLQKLELTIEGNRVEEEDIGEEEEEEDEEEEDDDDDDEGWITPSNIHKLKRNATLGSMETREVKVGCITTDFAMQNVLIQMGLHVISVEGFLIRRAKSYVLRCHACYKVTSEMMREFCPNCGNRTLTKLTCSVDSDGTIRYHFSRRRPLNTRGLIHPLPAPQGGKHAHNPRLHEDQRAPQQRVARKARGKTDVWTEDYFVHSSPFATRDVMSRSAHLGIREGPGYTNFRSRQNPNEVKRHKKRNRKK
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MCGIKYCVVLFALVLRTSIFGEGKIVNEDEFGALCGMINFAKGALQRVEEAQEVNKSLTKIGSRCLELAGDVKLSNTCIDNNDESCEYSKVFWDAAKLSMSEGNAGKESLDDEKLEKVKQVASAAETIYGNMTKRHWVLNGDIIKQMLNRALYGIPHQPKKMRERSATRKRVCEGDVSQPEVNQGPVSLSRDLLCLCATDRKSRRKTKLCCENCVSGENRRVWRPRNDAQKRWNFLVSQCSNVEGHKEGFAKLVEKFRRSLNHRVDGCSGTMYVLGKHKKQLFWPLEFLSGYVPGPGVHYIINTRAGMVEDIPWLGELREIATLMGDLSEDNVEGRGLKSAIEKLEGDLEELFPTGGVRRG
The following text describes a protein:
Function:
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.
Sequence:
MKHFAKTNLVNLYLESLLASNPQLGLVEDQRIIYYKKKKSDKVRVISGGGSGHEPSWSGLVGSGLLDAAVCGDIFASPSARQVMAGIRASEPDSGVILAITNYTGDKLHFGLAQEKFQAESGGMQVAVIPVTDDVALGRTRSSKVGRRGLAGNLLVLKSMGACAEAGGSFDHVSNVGRAVNDGLVTVGCSLDHCSVPGRTDVDFHIPHDKAVLGMGIHNERGLVEVDIPERPEDLIKQMLTLLLDPNDKERAFVSFKEKDEVILLVNNFGGLSNLENGALTQVALSVLEQDYNIVPCRVLSGAFETSLDGPGFSITLYNPSYSATLVEKLSSKQLLELIDAPTDAPAWPRVGVNEPKKQKVLSKQEELAAKDCEESPYDELVSRICKHVISIEPSLTTWDTVMGDGDCGMAAKDAALHIQKEWNSRKQSSLKGTLNLLSSCLDDMGGSLGAILGIFVSALIYNLQKEGVEQAPKAVGLASKSLQTHTQARKGDRTVMDSLIPFCEVYASSGSLQHAAKAAQEGAESTKTLKAQYGRASYVSKTADVPDPGAWLFAAVVDQLSK
The following text describes a protein:
Function:
Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion (By similarity). Plays a role in long-term memory formation by processing the unspliced Orb2-isoform A (Orb2A) mRNA and thereby controlling Orb2A protein abundance.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to synaptoneuropil region of neurons.
Domain:
The KH domain consists of approximately 70 amino acids and includes a conserved hydrophobic core, an invariant Gly-X-X-Gly motif, and an additional variable segment. The third KH domain (KH3) binds a hairpin RNA loop containing the 5'-UCAY-3' motif on targeted molecules. RNA binding by KH3 requires residues C-terminal to the KH domain.
Sequence:
MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYGESVCSGIEVEIENNNNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPGTTERVCLITGSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERDKQVKILVPNSTAGMIIGKGGAFIKQIKEESGSYVQISQKPTDVSLQERCITIIGDKENNKNACKMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNSTLGTTIGGANSAASLLVNGTGINLSINLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGAHSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAAAASRPTQSQLDAAAVQFDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDLSSKDSKNVEVPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAIAKAQYLIEQKINEEETKRARQIPLTTVVN
The following text describes a protein:
Function:
Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.
Subcellular Localization:
Cytoplasm.
Sequence:
MNILERIAKEVQEETKVRLHARNVERVLQALLKTGDFWKIVDYSDLPVPAASGIIKKFLDEGIVFIDENENILFTQKGLDLVKELGIEPFEEHKCRACEGRGIPFYDDKELYRTFVEIAKDRPKPVQQYDQGSVTPETTVSRVLFLDSRGDLRGKEIIVMGAEDDLTGLAIALTRKAKRVLIIDIDERLIDFDNRIIKELGIDNAEAMVWDLRNPYTEDFLGKFDVFITDPPETFAAFRAFIGRGIATLKDAGCAGYFGLTLRDSSIFRWKEFQEILINEYGVVITDIIQDFNDYMNWEYHPETRAAQIAPVKKNPTDIWYRSAWYRIETLPGFKRWNEPISDEVFYLDEEGSTT
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEALIFPDKSRKAFLIDEKDMETALKELSLPAHLIDSIMREDRQRAIPHDGLTLILRRFTFEEQLEQHPFIILLRNDFIAIISGKDFLERIKEDFERNSYDCKSSLDVFMSLSLLRLVDEYYRVYDAIEDEIDELEDEVSENPSKIGIDEFRRVRDSLIRFRRALYSFREIASLMLGRGVYEISDNAERIIQEVYEDLVQLMDMVESQRERLADVRDLHLSALSLSLNEIMKKLTAVNVIALPLIIIAGIYGMNLMIPEAKWPYAYPAVLIAMFSIAFLLTLILRRKGWI
The following text describes a protein:
Function:
Catalyzes the synthesis of phosphatidylinositol (PtdIns).
Subcellular Localization:
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MGKNEQKDPNVYFFVPNLIGFTRVFLVLISLYFMSWHPNYCTIVYLYSSLLDAFDGWAARKLHQATNFGAILDMVTDRCATSCLLCFLCAAYPKYAIIFQLLVSLDLASHYMHMYSTLHQGASSHKTVTKKHNWMLRLYYGNNKVLFIFCAANEMFFVALYLLSFTPRTPPKLGYLPVPSFIYSTGELPLSYPTLLAVLCGPICLAKQIINVVQLVNAANALVKMDVEQRRAAKKLQ