lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MRVAPLYSLSCSFPFLARSPSFAPHHAPHPFTPTQCIPEQRRVLTVRRRRAILPVVRFRTLSMSLAAEHTEAGAPARKSSKVEPPTRNPDPNFCSYYVTRKHRFCRTECKPGSLYCCTHNIAETGAAPSTAPRAVKDVTSSPSDVAGCRGDVRVPCPISSNHTVYASRLERHVKVCPDLRYVTHKLPYFSNDKHANRGAVLVSSAFNAPPGGESQRCTHRDFSAEGLAALIRKVHECYDSCIAPDLVVLRQPSRDREAASGEVGATTTPQATTSCRGSAPVAREEISSLKHGPQHMGLIRCLSDVVRQAQDTDSILVGRCSSQCAPIHVDGFLEFGAGKGGLSAALQQLIVQRLQGVDCTTTSVGEDAEAGTVPSSHREATAETSPLMPSVPQSSWKSDFLAEVAQRPPLVVLDMNGFRRKSDARVRHSAVPLQRLRINIKDVDLTRAFLSEIRPLPTGEGEAAAAAVPSTIARPLENWAVLGKHLCGACTDFALSCLTESPLLTSQAQVRLPIVVIATCCHHRCELKHVNPPEQAEVAPAPLVLPGTSFTWSEQEFAALASMSSWAVCGDVVDEERRAVGRKCKRIIDQLRVHFLRYLGYVAFQCQYTTRDVTEENVCIVAFQAS
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MDYQKVLEEIKHRLDIVELISEYIDLKKTGQNYKSLCPFHSEKTPSFFVNPSKQIFHCFGCGKGGDIVTFVMEYEKVSFLEAISILAQKTGLEFESVKKSISHISKERLYAIYESATRYYMEQLNNSENAKQYLIKRGINQKTIEIFQIGYAPAEKNSLYNFLKEKNFDDILINSSRLVSNSYDFFRNRIIIPIHDLTGRVIGFGGRLIDSSSELPKYINSPDTPIFKKGENLFGLWHSKQHIREKGYVIVVEGYMDVILCHQYGFKNVVAPLGTALTQEQLEKTKRILNNLKKFTNKILLIFDGDEAGIHAAQRSLLPLFYGGFIAKIVLLPEKEDPASFLQKYGDKAFKNYISKALSPIDLIIKTYPKNKLNEGIHSFLNSLSYLKDLIYRDELLKELSEKTGINEKTLRDELKQIVHNKNFKKEKINIKNYLVSKEEEILLRIALSYPEKINYILQKINIEDFEVTIIRNIFSKIEELQKHGQFSLNKLLNIIDEEEKTFISKLIMTSEIDEELIMQNMNDCLKSLAIKSIDKKIKKIAKSGDEKTLQELIRMKKNIIKNHNG
The following text describes a protein:
Function:
Catalyzes the sodium-dependent transport of glutamate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIELNAITTLCLACILYLLGKAIVNHVNFLKRICIPAPVIGGLIFAILVAALDSFGMVKIKLDASFIQDFFMLAFFTTIGLGASLKLFKLGGKVLLLYFMFCAIISVIQNIVGVSLAKVLNIKPLLGLTAGSMSMEGGHGNAAAYGKTIQDLGIDSALTAALAAATLGLVFGGLIGGPVVKFLIKRYNLKPQHSDDTFKDYSQVAYNEHLHSKFNATEVFFIQFTIVVFCMAVGSYFSHLFTAQTGINVPIYVGSLFVAVIVRNISESFNFNIVDLKITNQIGDVALGIFLSLALMSIQLIEIYKLAIPLIIIVLVQVVVMILFAVLILFRGLGKDYDAAVMVGGFIGHGLGATPNAMANLDVITKKYGNSPKAYLVVPIVGAFLIDLIGVIVIMGFIQWFS
The following text describes a protein:
Function:
Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP.
Subcellular Localization:
Cell membrane. Note=Localizes to the apical region of the pollen tube plasma membrane.
Domain:
The PRONE (plant-specific Rop nucleotide exchanger) domain is responsible for the GEF activity.
Sequence:
MVPSLERGISITSSFNLDRMFDSSPGKEQQQPHLAETTMPESQTQDSLGGSPVETSRPMTSRLISRRQDKQQSETEMMKDRFTKLLLGEDMSGGGKGVSSALALSNAITNLAASIFGEQTKLQPMAPDRRARWKKEIDWLLSVTDHIVEFVPSQQISKEGVCTEIMVTRQRGDLLMNIPALRKLDAMLIDTLDNFRGHNEFWYVSRDSEEGKQARNERTKDKWWLPPVKVPPNGLSESARRMLHFQKDSVSQVQKAAMAINAQVLSEMAIPDSYIESLPKNGRVSLGDSLYKSITEEWFDPEQFLSTLDLSTEHKVLDVKNRIEASIVIWKRKLHLKDNKSSWGSAVSLEKRELFEERAETILVLLKQKFPGLPQSSLDISKIQYNKDVGHAVLESYSRILESLGYTEMSRIDDVLYADSLARKQCTGEETSDGGKIATETDSASAGSSNYSGEEIEKLESQNSSKTTLLDFIGWSDNSSKGQSEKPPKSPRMTPKKLSYLEKLENLNGFRSPKDRH
The following text describes a protein:
Function:
May be involved in a process influencing telomere capping.
Subcellular Localization:
Vacuole.
Sequence:
MGARRESGLHSFLNRKTPPTADMQQGSGGTRPQPFSRFTYGSKSAQSSGGMGGQVACSPKGRGSQRSLLSSNFPFMESVFEDRTAAPQRTPTPRDERSEYFGEAEGSSGLRSSLQCNRELASLDKINDAQARMVVVAGKSHLGLYKFDEAYRMQQVHDYMTPGSLGGGTKFSSSMRRNMRKISTISDVKAGFHHHKNYIAICGTSTSVSIYDINRASAKDSPLITTLSEHSRSINSVDFNMGQTHLLISGGQDGCIKVWDLRSHSYKVNRSDLNFNSGSDSVRDVKWMPTYDFASLGADTSLCSSGRSNKFASVHDSGLLLTFDMRQPNQVERKINAHSGPGLCMHWHPHMDYIISGGRDGKCALWYVGDKVNSMVSVPQGHNSATSYSINTAPITTGYLETVINTSHPVSKLKFRPKYVHNMLNSLIATSSMGEDSDVTIYSLARKHIPQNILTTAAPSLGFVWWNEDIVFNIDKQSVISAWDIRYEPTLLDNLPKGIVKWRDMDGSGLVFVAQEKGTYSMDNGGVTDSVGKGAANRMSNTTLNSTNNMGRDQEVFTYSFQQQYKHQDQEAADRESDHDKELEKERETEVDQHYHYLREQEREHHQEYQEWEHEPFGRHDDHQGNPQTDFYSHAYSDRPMLSKALSTYSSKIASPILSYYGAQTLSHHTSIVSNSPSISGAALEYPGGIESPIMITLDLPQVFGSVRASRLADRKTSKNKGNAPAVRESAVDIFKYLVRELELCHVQERNDPKSISVDDRSKSLDDTELKIQLMENIGLSEHNTWATLIRSTTSMDTNDPAGSHTQGHSKLVDMVKLQGSNILSPDNSDMEDDLGDKLDEMGTARLQENVNHLVGLIFLSTHNAETYASVNDLQNFKIWMLIRDSLLNDLKEAADGSTGRRDASGGAANSDKNGIYTTTSTVNHARQDSITSNFSSFEPSDISRSDGEEKLNLGRLSEQNLKATNQNTTAKLDDTRKLASSSSLNSSEPLLLLEGGNQAKEQSIGLSDLKTCLKERYTASNESVLDIEEESSATVAYSSKQANTECSSSIPIRKTEARTSFIDTIMTNLRSPGLSHLDVDNDAIFGKGKTSTSLGSGASKRSSMHSTDSYHKRPYSSPITYSKITTAAQKAKLGLADHDGLPNRGSISFLANIDAAHADKLLLGKLGLASSPDDGKLLPPWDTGRLIQQLYRYSVETGNIILTVCIILLFQTMYKVTSTRIVKSTLAEFITILHRYEMFEISAHLLKNCPWDDILGAGSGQSTVRLFCENCGKLIVNEHSKTILSKRHQAGESNMTNFGYWYCDSCRKPNSLCVYCEQPMKKLALSFLNCGHGGHFECLQQWFLDEGMSECPSGCSGVLL
The following text describes a protein:
Function:
Transcription factor. Probably binds E-box motifs 5'-CANNTG-3' in complex with transcription factor TCF3/E12. Negatively modulates transcription of target genes such as CDH1/E-cadherin, perhaps by recruiting the PRC2 repressive complex to regulatory elements. Regulates ameloblast development and tooth germ growth, perhaps acting by positively modulating migration of inner enamel epithelium (IEE) cells. Plays a role in enamel formation.
Subcellular Localization:
Nucleus.
Sequence:
MPMGAAERGAGPQSSAAPWAGSEKAAKRGPSKSWYPRAAASDVTCPTGGDGADPKPGPFGGGLALGPAPRGTMNNNFCRALVDRRPLGPPSCMQLGVMPPPRQAPLPPAEPLGNVPFLLYPGPAEPPYYDAYAGVFPYVPFPGAFGVYEYPFEPAFIQKRNERERQRVKCVNEGYARLRGHLPGALAEKRLSKVETLRAAIRYIKYLQELLSSAPDGSTPPASRGLPGTGPCPAPPATPRPDRPGDGEARAPSSLVPESSESSCFSPSPFLESEESWH
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSMSQSALIKEEISSVSFQFYTSDDVRKLSVKQIVEIESFDMLGGPVPGGLHDPALGPTGPAERCATCSLDFIECPGHFGHIELAIPCYNPVSFQTIFKLLKNKCFHCHHFKHGKPIINQFIEELTLLFKGDVVKARNLRERNVLLRGYEEKKKGKSNEEGEEVMESDESDSDKMDTDENKTNGKIICDGVFNAKEIYSGKATHIEDFKREVFKEFFGSFSGYAIPCGNCGAYSPRLRNGDASKSKLFIMPLHDKYATKNSAIKLPTNFSSVKEQTEHGTWFAPWEVLDNMKKLFENEKEILDMLLGHLVPIVTNKGGAKKNVGRQFTKESNVDSLFMRVFPVTPARYRPPNFVNGRRSEHPQNSHYKGMVKSNKMIRQSIDAGEGKAKFLVNSVCDLQMHVNNMYDNSKSNSNTNEVANGIKQILEKKEGLFRKHMMGKRVNYAARTVISPDISLETNEMGVPQYFAKTLTFPQPVTSFNYNQLAQAVINGPEQYPGANFIEDENGHLINLSKESQEKRIALSKTLLTSHPHAPRGVNKKVYRHLLSGDYVLANRQPTLHKPGIMGHRVKVLGKNEKTLRMHYSNCSTYNADFDGDEMNIHFPQSLLASAEIREICANNYQYLVPRNGAPLRGLIQDHILTGVLLTKRDTLFTKADFQAILYASCWSVNTKHPIVTPPPCILKPVPLWSGKQLISAALNQLTIGRAPLNLEAPSKIPTKMWGTKGLEITRDSHVIIRQNEMVAGILDKGHFGASSYGLVHTCYELYDPDVAGSLLTLLGRMFTNYLQSRGFTCGVDDLLMKNKEEKFRVETLKKANEEGYTVAAKFADLSKYDEQKARDFFSKALQSEREVARLDGLLKKGLNQYTSKVIDTLIPGGQQKPFPKNNFSLMTVSGAKGSVVNFSQVSCLLGQQELEGKRVPRMVSGKTLPSFQAYDASARAGGFVMDRFLTGVRPQDYFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVQYDNTVRESDGSVIQFNYGEDSLEIGKTPYLTKFPIIAENYELFKSQFPMEQLIEQLKNQEVVEYNRSIKTQPELDPVMSKFNPSSDLGCVSESFMNQLNHYIESNPQKLIKTTSNRDGKINEKDFRNLMYLYYSRSMVSPGESVGLLCAQSIGEPSTQMTLNTFHLAGRGEANVTLGIPRLRELIMTATTKPITPLMEFQINDSTNKVETEKMAKYLEILKLSDIIKDITVQEYFQDTNRNYDIEIEFIPTLQQVLSLHRIKEKQLNKLFGEFNKVIKRQVKSQGKLKVNNGDIGLGSKVRGSDLVEDDSLTINDDDAPANDDTTNNDENTSQQQPSSQNKKSKSKVITQDDDSVAAKSKNKKKQNVNYEDGEEEAEEKDSDEGESEAEESDDKSDVDSDSDEISNSRSSNSFSDESIEFDQKKLTFTISVASDSKKVLMLGIVETEASKFVLKSCKGITRCFVNEKQVGGKTHYSIQSEGVNLSEIFELRDKLKIDEIYTNDIYAILQKYGVEACRQAVTSEISNVFAAYGISVDKRHLILLGDYMTFEGGYRALNRIGIENNTSPFQKMSFETTFSFLSKASLMGDYDTVTSPSSRIVLGQIVKNGTGSFTIVAPVK
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVSYYEFTRDGKKVIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKQADEFVVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNMEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVEREKEIQNFEPKPYWVIKMLLEKNGGQYTAVYEKEKVWDEEEAKKIVEEAKKGPAFVEKVEVKQQNRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQKLYEKGYCLHPDSLIPTPQGVKRIKELPEKGEVFALDFDLKLSRARYRLLERDADEPMYKVTLSDRTELYLTADHPVLVYRDDQLIFVPAEELRENDQVVLFINRSEYSPRTESPTLLGFLLENATSMKDYILYDPEFGGVLRNRIKDAGLKTEILWRFRIREPTYYKYLRGKMPVPIVRFLLEEGVVSIEELREVFRGFSYSTSLTPISFEFSEEFWYLFGLVAGDGHLAKKGAITIPAKDRTEDTVKAVKEIANSLQVPFAFDEKYKMIILRSKSLTRLFELLGCPYGNKTEIFRIPGEIMAKPEWMAAFLAGYYDADGHIGTKPTGGKKSHSPQIVLTSKNRMAIYTVKQMWQLLGVGTYLWEKKDRNGNFMAYELKVYSRDAWRFYEVMKNHLRIKRKDLEHVKEVAIRKRKAYSHHYSVLNVKSWEGKIKSSNVLWKKFDMSNQTAHGRGISLDKLQRIVDYLTDTDLRRIAMGDVYVLGIRSIEKFHYRGKVYDLVVDQYHNFIANGVVVHNCSYPRTSSQKLPKNLNFRSIIQNLAKLPEYKPFAHELLGKESLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEGNLYDLIVRRFLALFMEPAVRETMKVVINSNNHRFILSGARTLKEGWLKVYGKYVKFDEVILPAFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIKVTPLGMRVVEALEKNVPDIVSVELTRAFEEKMEEIMAGKADKDQVIEESKEQLIKILQVFKEKELDIGKMLLESTGTGVTTSKEAAKKTGAVKDANDEEKSDGKAGEGTTPKAERKPLVVGKCPKCGGDLVIRYNRKTGKRFVGCSNWPKCDVTYPILQRGQVIPTEKTCCNGAPVVKIREKGREYEICLDMNCKDWKKK
The following text describes a protein:
Function:
Involved in transcriptional silencing and telomere length regulation. Its role in telomere length regulation results from either a block in elongation or promoting degradation of the telomere ends. Loss of RIF1 function results in derepression of an HMR silencer, whose ARS consensus element has been deleted, and in the elongation of telomeres. RAP1 may target the binding of RIF1 to silencers and telomeres.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MEHVDSDFAPIRRSKKVVDSDKIVKAISDDLEQKNFTVLRKLNLVPIKKSVSSPKVCKPSPVKERVDHVFYQKFKSMALQELGTNYLSISYVPSLSKFLSKNLRSMKNCIVFFDKVEHIHQYAGIDRAVSETLSLVDINVVIIEMNDYLMKEGIQSSKSKECIESMGQASYSGQLDFEASEKPSNHTSDLMMMVMRKINNDESIDHIVYFKFEQLDKLSTSTIIEPSKLTEFINVLSVLEKSNNIAFKVLIYSNNVSISSLLSTSLKKKLNTKYTVFEMPILTCAQEQEYLKKMIKFTFDSGSKLLQSYNSLVTCQLNNKESNLAIFFEFLKVFPHPFTYLFNAYTEIIVQSRTFDELLDKIRNRLTIKNYPHSAYNFKKNQRLPLKLTRKVHDR
The following text describes a protein:
Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MEIKDLQDYVAIVNDWPKKGIVFKDITPLMNDGEAYRFATDKIVEYAKELKIDIIVGPEARGFIIGCPVAYALGIGFAPVRKPGKLPRETIEMEYDLEYGTNKLSMHSDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGIVAGCAFLIELKELEGHKKLNGYDRLILMKL
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB24 (By similarity).
Sequence:
MLSIDTNILLYAQNRDCPEHDAAAAFLVECAGRADVAVCELVLMELYQLLRNPTVVTRPLEGPEAAEVCQTFRRNRRWALLENAPVMNEVWVLAATPRIARRRLFDARLALTLRHHGVDEFATRNINGFTDFGFSRVWDPITSDG
The following text describes a protein:
Function:
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.
Sequence:
MELSYQALRVASQNREAEELRTEARRKNLLILIMHYLLQEGYVDSANSLEQETKISSRRFEVCDNVDLETILMEYESYYYIKFQKYPKITKKALDHDSRVQPKPRSAGKLRRAGSNSTQGLPRISQQQVIHRPVSSTYYRTNGHQKALSRENSKQESGGNSPQEASEVGLNVSAISKASGEGSHTRRRQVIDFRSMIQDTIKGASQEIALNSLNCNPDPSERLIKPVGAFIGGNSEMRELAAVISRDIYLQNPNVRWDDIIGLDAAKRLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECNTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTGPGGEHEGSRRMKTELLVQMDGLARSDDLVFVLAASNLPWELDYAMLRRLEKRILVDLPSKEARQAMIQHWLPPISNSSGVELRTDLDYSTLGEETDGYSGSDIRLVCKEAAMRPVRKIFDALENHHSEHKKLPVISLETVTTSDFSEVLAHTKPSAKSLAEKYSAWQNEFESV
The following text describes a protein:
Function:
Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptococcus coelicolor.
Sequence:
MNERADRSGGAAPGGDRTHRVPVLVVGGSLVGLSTSVFLGRLGVRHTLVERHAGTSIHPRGRGNNVRTMEIFRVAGTEPDIRRAAATLADNHGILQAPTLAGDAGEWLFKQIDPGGGLARFSPSSWCLCSQNDLEPELLTHATNLGGDLRFGTELLSFEADTEGVTAIVKSRETGEHTTIRADYLVAADGPRSPVREQLGIGQSGPGDLFHNVSITFRSRRLADVVGDRRFIVCYLTDENADGALLPVDNRENWVFHAPWHPEQGETVEDFTDERCAAHIRRAIGDPDLDVEITGKAPWHAAQRVARSYRSGRVLLAGDSAHEMSPTGAFGSNTGIQDAHNLAWKLAAVLEGWAGEALLDTYDTERRPVAEATSARAAHRSVEHSHPGFAPPPVAGGGGPGAGTPGGAGRGTGGPGGPGGPGGLGGPGGPGGTGGPGGPGGPGGPDGPRGAGGAPGGGPGGGPGGGGPQRGILNVALGYRYPRGAVVGADPATPVVPEGLDLTGAPGSRAPHLWVRRGQDRLSTLDLYEDSLVLLSDAAQPTGWHEAAAGVAAGMRVPLKSYRVGGSPGADLNPDDEETDWARAHGVTRGGAVLVRPDGFVAWRSPGPAPDPESMLRQVVGTVLARS
The following text describes a protein:
Function:
May mediate the reduction of outer membrane cytochrome b5.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MLSRITRSSKALNFALGTTAVAAAGYLYAQSRGNLSTSLNKGDVTGQAAAQTFTGDGQWHALKIAKIEQVSHDTRRFTFALPSQDHVTGLTTASALLAKYVTPKGSNVIRPYTPVSDNMARGMFQLVIKHYDGGKFTTHLFGLKENDTVEFKGPIQKWRWDPNMFDSIVLMGAGTGITPLFQMMHHIAENPTDNTKVHLLYGNKTPQDILLRKELEELASKYPDQVKVTYFVDKPEGDYKGEKGFITKDFLKQNLPTPGSNSHIFVCGPPPFMDAFSGNKVSPSDQGQVTGVLSELGYTKDHVYKF
The following text describes a protein:
Function:
Serine/threonine-protein kinase.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKRFINSTVTFSVTVTIAVIIFFLLSPVTSLGSGSTYAVVYGSDTVCALISGQPTQRILCYDTRLNINVTLNPGVSFSSIAAGDNFLCGIRSGGYSLLCWDNIGSYSPNRKRIYQNDNVLLETLSVGDKQICATVNGTNSLKCWRGSVSDQSKPPNERFRSISSGVGFSCGVSIRNNRILCWGTDPVKSNQIQTGFGNTPMVTISAGKSHACGLNTTGNLICIGNNDSGQLNVIAPDQPNLYSSSLSLGSNFTCAMRISNNSVVCWGGGAERFNNVTDSISFESISSGPGLICGLISSNLSIMCWNPTNFSRIFLPFPEVLPGPCVESSSSSLCSCGVYPQSDKLCSGTGSICKSCPIQFPASPPSQFPLPPPPPPPPPSPSTSSPPSKALTRGLLAFAIVGSVGAFAGICSVVYCLWTGVCLGKKKVHNSVQPTITRGGSNSRSNSSNSRSLSIRRQGSRMLSMRRQRSGTSSMKHADKAEEFSFSELASATGNFSLENKIGSGSFGVVYRGKLNDGREVAIKRGEVNAKMKKFQEKETAFDSEIAFLSRLHHKHLVRLVGYCEEREEKLLVYDYMKNGALYDHLHDKNNVEKHSSLINSWKMRIKIALDAARGIEYLHNYAVPPIIHRDIKSSNILLDSNWVARVSDFGLSLMGPVLGKDHNPYQRPTKAAGTVGYIDPEYYSLNVLTDKSDVYGLGVVLLELLTGKRAIFRNNGDVEEEEGCVPVHLVDYSVPAITADELSTILDPRVGSPELGEGDAVELVAYTAMHCVNAEGRNRPTMTDIVGNLERALDLCGDSHGSISSGICSIVSD
The following text describes a protein:
Function:
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Subcellular Localization:
Cytoplasm.
Sequence:
MIHFSINKNLFLQALNITKRAISSKNAIPILSTVKIDVTNEGVTLIGSNGQISIENFISQKNEDAGLLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQNQIVLTSGKSEITLKGKDSEQYPRIQEISASTPLILETKLLKKIINETAFAASTQESRPILTGVHFVLSQHKELKTVATDSHRLSQKKLTLEKNSDDFDVVIPSRSLREFSAVFTDDIETVEIFFANNQILFRSENISFYTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSMERARLLSSATQNGTVKLEIKDGVVSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYLIDSLKALNSEKVTISFISAVRPFTLVPADTDEDFMQLITPVRTN
The following text describes a protein:
Function:
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.
Subcellular Localization:
Cytoplasm.
Sequence:
MEYMSTGSDEKEEIDLLINHLNVSEVLDIMENLYASEEPAVYEPSLMTMCPDSNQNKEHSESLLRSGQEVPWLSSVRYGTVEDLLAFANHISNTTKHFYRCRPQESGILLNMVISPQNGRYQIDSDVLLVPWKLTYRSIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYLPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEALNPPREDQPRCQSLDSALFDRKRLLSRKELELPENIADSSCTGSTEESEVLRRQRSLYIDLGALAGYFNIVRGPPTLEYG
The following text describes a protein:
Function:
Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis.
Miscellaneous:
MISCELLANEOUS: The MX region mediates a post-translational regulation, essential for the onset of hermaphrodite spermatogenesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLRSNKLLVAAVIFTVVTFGLLLTSSIFNNKTTTSLTYGGILPKFGQRIIEKKSNEEYIIEKIEHTQKDGEDVRSTRYLTHHSYLLRNLAKMEVKHHGKDFSINDICYKPHNAIFETTFAPENIDKLPNYLQRLILEAQRLSPCLIVTPLNCYHDSYRIHSEMSKWNTSNVTNFLNRKLRNSYIDAIGESEERPYIKSTYGPDLIKEWAHLMFKLPSKQTSSFSKKDLSSKIELWLSSIESKTNLTELGRPSEVDNYFDICTSMQQVHDFDERKRKFGLYDDDDEFLIGLDCVENKTKFIEWIQERELRGVSKPFNPNQQCDGIFKNSEGLEFFYGTRSFGNNTAPFDKMKTEIGLMTPEQILTTMLHSDFVNGFESIWTIERAQELLDDFRLAIRQEVKRFNENRSSLKIGIDTRVVQREESNETELEISSNLDSVVYFILFIRCVLLIFFAFFAWSVNPLRSAVMFLVRDALTSLLFSILCKSDGQIELNSELLGYIILLTIVNTYLTTRVSWYKDRNETCIQRAKDFPSRSNFSLLFSIDSLRENCDSRQLQYALAKLSKYLTALDTYSTETFMQLPNYWPFISILFVPITGCYWYFVDINLPKISVVLLPSFIVATIEQRQVEKSLLKERKAKKEFQKVQKKKMEKFLSDGAVDRLLSGNSESVEDKKLYKSKDCVIHKESAGRLYELSRSSYDVSKIMAYPNQRVRDFRFDALGCYFWLMKLKSAGILLYGSAVLFVLLSVAVMLIPIQRTSLQKDMNNEVYFGFSINNMSSDWANINKNLHAFNSEIDSIQSLQTISNWKKGFDRFEGRFYKNSSRISDANDYVEWMNQEPINWSVMAPLTRISPKFGIPSPFKFRFRYQIEVNNNESEVIDTVQRIDTLLTKYKGTLSSPIVDGVLYEYYHGNAAVWNSFVFNELLASGILSAFFALIVVIFSITPSISSVLIFSFFVIGSRLEIAAVISLFSLDNQQLYTDSAVLVGFLVAWAPFYELSLFRRRLLYKLKTRCTPELSSGKRIRPPFTKAVDTAQVFAIVLAASLIIAVVAGVVPEFQKFFWPTVILIVVQLVAFGNSIAVLVATNQMFEREVRNFLDNEFELGNGTTAGQVCHMAQKLIPPKYDIPIPMNDFHIRPTNMSKFYAPPPAKKRAKQTNNETDPEKKEDEPGTSNANNVSQEEAAHRLAILPWHFVLGGIPVDLTTRSDQIINGPFIGISSDAMRTHEINSELEDQDDYSSESSVEDVESDPAPEEEIKYHEENMLHMIEKVQKDAAEKEAKEKVHQVESAQRRAPNFDDPNVAGPSHRYQRNEERISTDIVPADPPREIPANPVPPPTHVLVQRAPRPHEMPPVIDRTIPRDPRTEPPNLQECIQQNDDPSLPPHPRRHQYPDHYGRAMISYCEDVYWTYNDGRLPPNVAMPPRPFDWHYRRVAPPEDFNYVPPPGQPSIPIPAEAMALREERARAHREQEQRDNSQSPSPSPEPGL
The following text describes a protein:
Function:
TQO plays a role in sulfur oxidation and is proposed to couple sulfur oxidation to dioxygen reduction; caldariellaquinone or sulfolobus quinone seem to serve to transfer electrons to the electron transport chain terminal oxidase formed by DoxBCE.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MERVTIIGIIFAILVVGWILATGQWAYGNVVGPLVNHSKIPLLKITYVSAYENAKGTYLILNITDCCGPDAYPASAPIMEIYNSTWHVFLYSYNISNDTVKVIQAPWNENKKDYTNWYSGFVVILGSEAQFQLQLPFHLSPGTYHIKLYTPAVSSKVLAKQTATFTIS
The following text describes a protein:
Function:
Probable chromatin-remodeling factor that is functionally redundant with CHR12 in root and shoot stem cell initiation and root apical meristem (RAM) and shoot apical meristem (SAM) maintenance. Can associate with the promoter region of WOX5. May promote seed maturation and repress initiation of germination. May repress plant growth.
Subcellular Localization:
Nucleus.
Sequence:
MVKQLQEQEENDPVEKTKSLISALNYLSRDLLLPSHLYASVSSIYHASVSDLSPSPPLRGNSYTPNRGDLMSEFEDALLQQRLNYESGSRLAELKETRYKNRIHNRLSQLEGLPSNRGEDLQEKCLLELYGLKLQELQCRVRGEVSAEYWLRLNCADPERQLYDWGMMRLPRRMYGVGDSFVMEADDQFRNKRDAERLLRLEEEEKNLIETTQRKFFAEVLNAVREFQLQIQASHRRCKQRNDGVQAWHGKQRQRATRAEKLRIMALKSDDQEEYMKLAKESKNEKLTLFLEETNKIFVSLGAAVQRQKDAKLSENTKLLKGSESDLSDVDAPEDVLPAQDIEIIDSDNNDDSNDLLEGERQFNLAIHSIQEKVTKQPSLLQGGELRSYQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENEFALWAPSISAFLYDGSKEKRTEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRLKNHECALAKTLGTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECGSASLTDEEELLIINRLHHVIRPFLLRRKKSEVEKFLPGKTQVILKCDMSAWQKLYYKQVTDVGRVGLHSGNGKSKSLQNLTMQLRKCCNHPYLFVGADYNMCKKPEIVRASGKFELLDRLLPKLKKAGHRILLFSQMTRLIDLLEIYLSLNDYMYLRLDGSTKTDQRGILLKQFNEPDSPYFMFLLSTRAGGLGLNLQTADTIIIFDSDWNPQMDQQAEDRAHRIGQKKEVRVFVLVSIGSIEEVILERAKQKMGIDAKVIQAGLFNTTSTAQDRREMLEEIMSKGTSSLGEDVPSEREINRLAARTEEEFWMFEQMDEERRKKENYKTRLMEEKEVPEWAYTSETQEDKTNAKNHFGSLTGKRKRKEAVYSDSLSDLQWMKAMESEDEDASKVSQKRKRTDTKTRMSNGSKAEAVLSESDEEKEEEEEERKEESGKESEEENEKPLHSWKTNKKKRSRYPVMTSSPNSRGKGSSKGSKRN
The following text describes a protein:
Function:
Methyltransferase which catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Sequence:
MEEQQRTEELLQGQLELWHHALGYIKSMALKCAMDAGIPDAIARCGGGATLPELLAATGLPPCNLSYLRRLMRVLTVSGIFHHQRKQPASGEHEEEAVYALTRASSLLVRGEGNGGAPSFGQLPFISILLGRTFVTPFFGMHPWIADERAAATSFFEREHGQALWEMARTSTGINDEFNQGMTADTRLIMHAVLTLSPAVFEGLTSLVDVGGADGTAAAAVARAFPHINCTVLDLPHVIENAPAPDEAAGGNTVRFVAGDMFHHIPSAHAVLLKWILHDWNDDECIKILRECKKAIPTRGNGGKVIIIDTVVGSNTCDNICNETQALFDMYIMFINGVEREEREWKRIFLEAGFINYKITSTLGYRSIIEVYP
The following text describes a protein:
Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Sequence:
MVILVRRRLARLARYSLTAIFLSLLLTAIITISYLNISYLCRIGKNNLDADFNVPAEINVALEYRGVETHSMMISYATLIIVDLERTSSLGYVAKPTRPTSVKIALKEDGFSNENSNPINQEDENTVQQGASKEKHEEHHRNINEFKRNDDIVIKANSNQGIKNTRTGSKNKNSLGLPSPSDYNQLKSFVLFCGFPRSGQSLVGAIMDAHPHMTIAHDFNILGGWSKNLSWRNDKKDLYRALYERSRDRNGNRKKLAGNRRNFFVPKLYQGTFQDYIQIIGDMSGQRLTQAYVKDFNKAKRNVDSIRHFIGMPIKFIMVLRNPFDTIATQVLRTLKAKARKKASKMQDTNLSEADQVNLTKVLLNKRIRAYLKAVEANKKIYRMYKNQTLILYLNEIVNSPDTEITKICNFLGIQCSKKYISLCSDIVNEQQSITRKQIQWTEHQKDMILNKISKTKWLRKFKFIDT
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVVLSASIVTKGGRPVISRQFREFPRARLESLLATFPKLIPPSSQHTVIDDPTSAIRYVYQPLEDLWLVILTNRQSNILQDIDTLHLLSRIVSDFCRGTVTEAEVLARSFEVLSSFDEVVCMGYREKIDLNGIRSVMEMESHEEKIQEIIAKNKEQEAKEELKRRAKQLDSQRREALKRGQSDVYSTGMGSGGGYDRPYQPSQPAAPVVREDPYSSRTPVAAKPFKTKGMQLGSKSKSQGVLGDEYAAQGPWPPVSVVQSSEPAAQPSSAPPASAAKAADLNPFAPETQEDVHLVLREKLSAELARDGGLVPNSTGINVSGSLELKVAPESETKIWVTLNHGVAKGAIPASDIQFKTHPNVDKKAWADSRVIKLKDAERGFPTKQGLAVLKWRLTTKDETLIPISINCWPTTNDDGGCDVNIEYEAENENVQLHNLVITIPLPEGSYPKVAQCDGSYEIRTEESPVLQWKIEGDDEGVAPSGGSMEFNCPDSDPDSFFPVSVDFISQNILSQVSVTQVAAVVGDEPIEFSSDTLLSTEEYAVV