lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for chromosome condensation and partitioning.
Subcellular Localization:
Cytoplasm.
Domain:
Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
Sequence:
MKIKRLDIVGFKSFVDKVSFDFQQGITGIVGPNGCGKSNVVDAIRWAMGEQSAKNLRGRSMEDIIFGGSEFRKPLGMAEVSMVFATDDGRVPAKYLSYSEIQITRRLYRDGESEYFLNKTPCRLMDITELFMDTGVGARAYSIIEQGKIGMILHSKPEERRFIIEEAAGVTKFKARKQVALKKIDLTRQNLLRIGDILSEIKRQLNSLQRQVKKAERFREYREELREIEIHASVRRFTALDAEKERIEGLLREAVSRESTLTADLERRDLELAEHRLALAEREKEVVTAQEGLFRQKADIQACESRIEFQRRELSSLERQQERVAVELATAGSQLVAAEEEFARLVEQSGSFAVEVAGEEESLQTREMELEEMTGAERELAAHLDEARRELFSLLSEIAQLNNQRTAAVRRLEGLAERADRNRREGTLLQERLVEATGKVHELDGTVSGLGRTKAELQERLPVVIRREEEIRQRLAEAEREFVTRRDELSRAASRLHSLQELESQFAGYGQGVRNLFLSERFAGRFGGVLADAVETGADYETALEAVCAERLQYVLSESDEAALDAIAHLKESGGGRCGIIVAGIPADDRSSVTGATPLLDRVSIAAAWRPLIEPLLADVHLADTLAQALSLSRQYPRATFVTLQGDLAFGGGIVNGGSAENAGQGLVHKKREIRELSGTVERLESAVRETETRREELRGERSRLEEEVRDLRQILHQTEIQFVNAEKDLQRAREECQRIEERIAIAGIEDEQLQDERRTLDEEIADADGRRAEREAKREALDAEVARTQEALTVSRRTIEAARDAVTALKVKGAQLREKREAASRATVRTEESIRDLRERIGRLRGEGESSAAEREHLAVAITAAEDDLKGHLAAYAEAETLSRSLRSEFDARVEAVRVEETGLRELRHQCEAARDEVAAHKLTLSGLTLELNHLISSLADKYRLEMREVMPSYADRPFDEEAAARRQAELGRLIDEIGEVNLTAIEEYRELEERFAFLSSQKDDLEESLQSLQQAIQRINRTTRKRFLETFTLVNEKFQEVFPRLFCGGRAELRLTNEEDLLETGIDIIVQPPGKKLQNVTLLSGGEKALTAVALIFSIFLIKPTPFCLLDEVDAPLDDANIGRFNDMVREMSDVSQFIIITHNKATMAVADTLYGVTMEEPGVSKSVSVKLN
The following text describes a protein:
Function:
D-galactose-binding lectin. Binds both alpha and beta anomer of galactose (Gal). Binds strongly to branched beta-Gal-terminated glycans and weakly to unbranched glycans with alpha-Gal on the end of chains. Has strong affinity for both Gal and GalNAc. Binds glycoproteins containing mucin-type chains. Has hemagglutinating activity towards human group A erythrocytes (Ref.2). Has hemagglutinating activity towards rabbit erythrocytes. Agglutinates V.proteolyticus bacteria. Binds strongly to fungi including species from genera Aspergillus, Alternaria, Fusarium and Haematonectria, and to a lesser extent to fungi from genera Trichoderma. Decreases conidia germination and hyphal growth of fungi. At high concentration, stimulates secretion of cytokines TNF-alpha and IFN-gamma from human peripheral blood cells, and at low concentration reduces hyperexpression of cytokine IL-10 in these cells, indicative of immunomodulatory capability. However, has no effect on IL-4 production (Ref.2). Recognizes pathogen-associated molecular patterns (PAMPs) and binds to peptidoglycan from S.aureus, but has only little binding to beta-1,3-glucan from E.gracilis and lipopolysaccharide (LPS) from E.coli. May be involved in innate immunity acting as an antibacterial or antifungal agent recognizing carbohydrate ligands on the surface of pathogens.
Sequence:
MTTFLIKHKASGKYFHPKGGTSNPPNGTNLVLHSDIHERMYFQFEVVNERWRYIKHVASEKIVHPFGGKADPLNGTNMVLHQDRHDRALFAMDFFNDNIRHKGGKYIHPKGGSKNPSNGNLTVMHGDEHGAMEFIFVSPKNKDKRVLVYA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.
Sequence:
MSIVCRLLVSIVILGSCLATAGDVGEQSTARPSSVTSESITTVDKRQFELSASGEILHDPATPLPTLANGHLGFAVYEDAVYLAGLYNGAGGLSHRARIPNMANVRLLLPSDLTLDLARGLFRSDFANDGRSFRLTHLLYPHALYRRVIVNQFTIERVGTNDENISLPMMPAPAFTSEDIQFQPISTHDARVHWSKSPAQPGDANVDPIYQSCGTTLQVENATYQNRGRSVCVLWNRVPERLVLGAGKRNVTYRFLMAVDGAEAIAQTEFETARALSDDALLESHTSLWRSFWARSDILITGNEPLQRTVRASLYYLVSNLPFEASFTVRSGPFWGLSPTGLGRGGTNLDDYEGHSFWDTEVWMFPVLNLIDPWYSRLLISYRTKMLPTAKRLAQEAGFRGARFPWESAFTGVEVTQPCCPAVAQYGHHITGDISFALRHYLGTTHDREGLRQLGGCEMAQQIAEFWSSRVRFNYTGSEQYDIPAVMGPDEDHENVTNNAYTNVVAGYALYFGEFARCICEADGRDDKGWSDIARHIKLPYDEIGDFHPQYDGYLASTVIKQADTVLIGYPLQYPGLKAYTRWNDLLIYEPVTRSTGPAMSWSMYAVNHLDIDNYREAAQNFNRSYQPYVRGPFRVWQELQGPAQHGAQNFLTGAGGFLQAVLFGYAGLRVYLDRLEVKAHYPQELSGVGLEQLQVAGIQYLGALITVAQWGDRAEVRVTHLDGELTIELGDGNAPVSVVCNRVYPVNKGVTAIIRTKAYPYGECELPKDVIGK
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.
Subcellular Localization:
Secreted.
Sequence:
MFGLNASALALVLGFSSVFRSGATAPSTCFHPDACEDIYARDNGAYSYTGPYSTGGVAWANGFAKAKTLVDQMTIEEKANVSTGFTGACAGFTGTAPRIGLKALCLQDGPTGVRPARRVSQFPPGVSTAATWDRELFAKRAEAIAEEFREKGVNIWLGPVTGGPLGRAPRGGRNWEGWSPDEYLSGVASYLTVKHAQEKGVVTSAKHYIAYEQETFRNPYNFSEPYQVYPLLQQKPVDSIVDDRTTHEVYLWSFAEAVRAGTGTIMCGYNRMNGTHACQDDYSLNHLLKEELNFQGAVISDWGATWSDQESVLGGLDMSMPGSAYDGMFGDFYGDSLVALVQNGSVPEARLDDMVLRILAPAFELQNESYPKTSFDVRDLTLPTNNVRANHHEIIHQIGAESITLVKNNNADGRGLPLNSPDELQTIGIIGQDAGDNLYGATSCDEFGRCNMDAFNGTLTIGGGSGWVLPPYVITPAAAIQEYVRASGPDINLHLDNWDLDGAKARANSSDAALVFTNAFATETNDRQNLTLWGNSDQLIKTVASNNNNTIVIIHSPGQVDVEQWIDHPNVTAVVFAYLPGQEGGASLPKMLWGETSPSGKLPFTIARKQSDYPPNTIVDDPVRTPSAPFTEKLLIDYKWFDYHNITPCFAFGHGLSYTSFKYSDSITVTSTPKPDETSIQPTKEKLINSQAALYDIALTLETEVTNSGEKAAAEVVQLYVSFPASAESRENPRPVKTLRGFEKIKDVQPGETRKVSFELRNKDIAVWSTVNQGWIIPQGESLTFSVGSSSRNIHSTASWVYRG
The following text describes a protein:
Function:
Calcium-binding protein maintaining matrix calcium levels at low concentration. Regulates mitochondrial calcium dynamics in planta by restricting influx.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion intermembrane space. Note=Located at the inner mitochondrial membrane and/or in the intermembrane space.
Domain:
The EF-hand domains have high affinity for calcium.
Sequence:
MPALSHYRSVSSLPSVDRSFLLIQRLRIHGSSSSFPESSPSASILSGADPLKCTVSGGSLAKWITGISAGSALGFLYWSSGSSDSISGLFGGSNLLSFADSSTPSVCGVKVGDLKPRSFIPKLSLPGYSSGFIFGDAYRRKIFFNYEKRLRLQSPPEKVFEYFASVRTDKGEILMKPADLMRAIVPVFPPSESHLVREGYLTGERNPGELRCSPSEFFMLFDVDNDGLISFKEYIFFVTLLSIPESSFAVAFKMFDTDNNGEIDKEEFKTVMSLMRSQHRQGVGHRDGLRTGLHMTGSVEDGGLVEYFFGKDGSQKLKHDKFTKFMKDLTEEMLRLEFAHYDYKRRGSISAKDFALSMVAAADASHLSKLLDRVESLSEHPHLRDMRISLKEFKQFDELRSKLGPFSLALFAYGKANGLLTMKDFKRAASQVCGITLSDNVIEIAFHVFDSNQDGNLSVDEFLRVLHRRERDVAQPIAKGLSRYFSDGWKGSKNCSSS
The following text describes a protein:
Function:
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.
Subcellular Localization:
Cytoplasm. Nucleus. Secreted.
Sequence:
GPLNSWIPPFSGILQQQQQAQIPGLSQFSLSALDQFAGLLPNQIPLTGEASFAQGAQAGQVDPLQLQTPPQTQPGPSHVMPYVFSFKMPQEQGQMFQYYPVYMVLPWEQPQQTVPRSPQQTRQQQYEEQAISGGQQQLAFDPQLGTAPEIAVMSTGEEIPYLQKEAINFRHDSAGVFMPSTSPKPSTTNVFTSAVDQTITPELPEEKDKTDSLREP
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MSSPPATMSVPPPRRVKSKIWQTCAGPSVNVPKVRSKVYYFPHGHLEHACPSPNPQTITVIDGYGPSFPCIITAVDLLADPHTDEVFAKLLLSPVTEGQEFPEVVDEEDDGGDKFVSFVKTLTKSDSNNGGGFSVPRICADLIFPKLDLNSPFPSQQLSVTDVHDRVWKFAHVYRGRPKRHLFTTGWTPFVNTKKLVAGDSIVFMKNTAGDIVVGIRRNIKFAAAETKAVNNKKEEGKENGLEVKREGFSRGGRRGMLTEKAVIEAVELAEKNLAFEVIYYPRANWCNFVVDANVVDDAMKIGWASGMRVKLPLKIDESSNSKMTFFQPQGTISNVSSVPNWRMLQVNWDELEILQNQNRVNPWQVELISHTPAVHLPFLSTKKPRLVQDSALFCDDKGDPFIPMIEFPKRSLNQTLLNCGYFPAGMQGARHDHLSLSGFSNSLNDNSYSFFVNNLNIDMPTTNDLSPNNLDSLNTFETDFVETHNSNIKGVGSGSIKLFGKIIKPVESDVHDSGTKGEDSSKGSNEI
The following text describes a protein:
Function:
Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery. Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation. Required for normal structure and function of synapses at the neuromuscular junction. Plays a role in synaptic vesicle trafficking. Required for the release of a normal number of synaptic vesicles per action potential.
Subcellular Localization:
Endomembrane system. Synapse. Cell projection, axon. Presynaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Recycling endosome. Note=Detected at presynaptic axon terminals at the neuromuscular junction. Colocalizes with Cdc42 and Rab11.
Domain:
In the autoinhibited state, the SH3 domains are bound to the concave surface of the F-BAR domain and prevent promiscuous membrane binding; Upon heterologous expression, the isolated F-BAR domain is localized at the cell membrane, and causes the formation of cellular protrusions. Contrary to F-BAR domains from other proteins, causes membrane flattening on giant unilamellar vesicles (in vitro). Binds to membranes enriched in phosphatidylserine and phosphatidylinositides, such as phosphatidylinositol 3-phosphate, phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Sequence:
MQPPPRKGNYVKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDNDPVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGTSGNQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPSLVVEECDEMGEPLSEGGDESPPPTAAPTFALPPAPALPPEYAHELELELTEDMFGSQDTADEDSGYIPNGAAAPSIPPPVLIQEPGMEDDLSDDGQPPPSLPPPQLAKAGGSAPGSGSKVEKGAAAGGANTLNLGMAQIIVTAATPMVEDGADKSFPPVGESDAQPVEPVSKEQPAEVAKKPDIAPKPLAKVAPQSAPAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTDSASVADVPVLQDAEDPFNEKAKGESGDGSGFEANFEANFDANFDDAFAGIGGGGGGGGGGGEQSNELDINGEAAGEAIVSGSAAGDEDIEAPKQVVGGRASIPEELDSNQLAHYHEHEIYYVDYSHGQL
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MAQNLYGPRVRIGNWNEDVYLEEEIMKDFLAKRDKGQLLIQRNRRLKENLLRPMQLSVSEDGYIHYGDKVMLVSPDHPETEADLFLPGDLSLCMTPDEIKAHLSNELEVPCGLSAAQTKIPVGRNTFTILCAAGEVIGQVLRYGQNFRLGITGGFDDRMLYLSSDHRTLLKSSKRSWLQEVFLTHEDSYLNCWQAAFPHPQLRLEYEGSPVPANTKILITHCHTNRGLVAHRHLFLRTYFGQEAEVAAHTYLDSHRVEKPKNHWMLVTGAPRKDLSTMLDLPKPPAEDTRALEQEREQVSDPGARSTPDARGCVPQCTLPM
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MGSSSVEILSLILTVSSFVSFILCSTTDCWRQDAKDPLSSVGLSSRCRGLWSECLFDNMAGIWTCDFLVSYLNEHPVALVVSRALVLIEGVLCFAAAPLLILGMGCTTVISNLDHHKQKFFTAAGIILLMAGFSGGTAVFWYAIDTATKYRTEVDLAVPGITYELGYTYWLAAASALCAVTSALLLMYLNCKAGKRSICTIEPGIHNNAITYL
The following text describes a protein:
Function:
Transcription factor that plays a role of repressor of filamentous growth and flocculation. Antagonizes functions of SFL2 and FLO8. Plays a role in the hyphal repression induced by secreted factors like dodecanol by competitors such as Pseudomonas aeruginosa and Burkholderia cenocepacia.
Subcellular Localization:
Nucleus. Note=Localizes to the nucleus in both yeast and hyphal cells.
Sequence:
MSHLVSSSLGTTTTATPTSRSPHTNHSTPYNQNSITSNRSSPVPKNSVNSRIIPQTMNPPIDMKSNNILNPEKDTDTSRGDHSESKASSISSASGTTTTNNNNVSNNNSTGKTQIVFIHKLYDMLHDESISHLIWWSPSLDSFYVTPGEEFSRVLSQYFKHTNIASFIRQLNMYGFHKVNEPFLNQDDQQQQQQLQSNRWEFRHSTNQFRKGDTESLKNIKRRSSKTLNAQKEVVNIKSLPPTSHPMEYNTGYSYQNEDSAHYFVHHHSITTMQSPADMRPRSPSTPIPMQPLAQQQQQQQQQQQQQQQQLPSQPVPNGPPVFSGPIPPGAVNQSPQEYLTRPSILNNVQGSFENATNFKFVELTNQINLLRNDFFTMNNRYEILQNELKYQTADSMAVLEILEKLSNDNRIATDIRDLKNVVSQRMQRLNNQFIPQQSNFAPHIPGQQQQQQHGNSVSSNYHLESTNVSRNPSTTNLNVAPQPYPLNPHYTIYANNRASGSSEINNGVFRAREDSNNSKRNLSVYDPLQPVPSRNSSRILIEESTPTHPPTNFNPQQSQSQSQVQLGPAMPPQGFRNRAESTYSPLSHSSNKSQILNKAPTPVNHSPLVQQQQKEAKQELNDSSVAPPSQSSLPVTRPLSRQQQQQQQTLHHPSTTSSRTNSLPNPVAEHPAPQSSYFMQRNSFNTVYEHQKSLRVPSPKRVRYATPPRSIPEQPISSTAPTTMITSTSKPTSTSGAAISRSENHSVVSLTGGALPSVSELDKSIRTGSSVSLPPIKSIKDNDNKNDNGNSDDNGNDHKKRKLE
The following text describes a protein:
Function:
Probable zinc metalloprotease whose natural substrate is unknown. Does not show endo- or exopeptidase activity against resorufin labeled casein, p-nitroanilide (pNA), amidomethylcoumarin (AMC) (one to three amino acids in length), and hippuryl-aminoacid substrates.
Sequence:
MKLCLVAFDGRIPMLSSIVDRFEEHVSEYLGEVKVKKKRAKLPEHAYSKVRGQYLARALLDTLRGMKGEYDRVLGLTSEDLYAPGLNFVFGQARCPGREAVVSVARLLDPDPELYLERVVKELTHELGHTFGLGHCPDRNCVMSFSSSLLEVDRKSPNFCRRCTELLQRNLKRGG
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWQTYVDEHLLCDIEGNHLTAAAIVGHDGAVWAQSSNFPQFKPEEIKAIMNDFEEPGTLAPTGLHLGGTKYMVLQGEAGVVIRGKKGPGGITIKKTNMAILIGIYDEPMTPGQCNLVVERLGDYLLEQGF
The following text describes a protein:
Function:
Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MEPPDQCSQYITSLLSPGVDDEKELQDMNAVVLSLTEEVKEEEEDAQPEPEQGTAAGEKLKSAGAQGGEEKDGGGAGAPGHLWEGNLEGTSGSDGNVEDSDQSEKEPGQQDSRPRGAVGGLEPGNAQQPNVHAFTPLQLQELERIFQRKQFPSEFLRRRLARRMNVTELAVQIWFENRRDKWRRHQRALMARNMLPFMVVGQPVVVTAAEAIMAPLFISRMRDGYFWGHSHSSSLCFPMPPFPPPSLPLPLMLLPPMPPAGQAEFGPFPFVIVPSLTFPNV
The following text describes a protein:
Function:
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MEKSWFNLILSKGELEYRCGLSKSMDSRLGPVENTTVNEDPTRNDTDKNIHDCSDSSSYYSKVDHLVDVKDIRNFISDDTFLIRDSNQDRYSIYFDSENQIFELNNDHSFLSELESFFYSYHNSSYMNNGSKNDEPHYHFNLYDNDTNCGWNNHINSCIDSYLRSQICIDSSILSGSDNSNDNYISNYICGEGGNSSEGKNFDIITRENGNDLTLKESSNDLDLYKDLWVQCECENCYGVNYKKSLNSKMNICEQCGYHLKMRSSDRIELSIDPGTWGPMDEDMISLDPIEFQSEEELYKDRIDFYQRKTGLTEAIQTGTGQLNGIPIAIGVMDFQFMGGSMGSVVGEKITRLIEYATNNFLPLILVCASGGARMQEGSLSLMQMAKISSALYDYQSNKKLFYVSILTSPTTGGVTASFGMLGDIIIAEPNAYIAFAGKRVIEQTLNKTIPEGSQAAEYLFHKGLFDPIVPRNPLKGVLSELVQLHGFFPLNQNSIK
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MARISELEFMMELSVNLSAGLSKKDLNQHLQIIHSTYRCLVCNFTTRSNARLNKHLSENHSSQSEQERMMNTSLSSNNENKKSKRSRKYTCKQCSFSTTIQEDIWMHTRVHVPASKLLSCPRCPFVCAFKHHMQYHLNNHFGFKPYKCELCNYRCNNKSMLNSHLKSHSNEYPFKCQQCSYASKYRQALYIHSIKTNHTLNENVSNVSSKENNKSFHLEKWNKFQKKSVTAFKNKNFNSRDVNRNLENINDFTSLEDVINNYKINTLNFWEMIESNACSKLNLNQTISPLDKYLLRNKIFPNNHPSMQQTSPVKFSNDSLMSYILSSPMPLFQNTTENTSSIRSMPSLLNNFKNEPQSPSSDFRKTPQSTNTPDFVDKKNQTSTSIENPSTLVNNNNKFDNAPNNQTRHLEQSTLQESSCLFPLDLSSSTNRAPSQSEGQNSPDNDLPEHCTKRDDDDKKAKSPMKAKKFKCYYCRITFDDEVLYGFHMDYHTPDDPYKCFLCKETHNGARLFFLHLHQVAHSFKFPKNFI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAEEESDLDSERLKEELESLLDNGGKGGNGLQSKLYCTRFCQVVEEHTGRCQVPLPQLQVLRTALCCFTQGIATFPADCEHVQYTLSSLALSFFELLLFFGKDEFLEDPLKDILDSFQECHSCLLGHGNMYLMLVKQIVKEGGPWENPVLQAILKEMPQHQEEVDRYLSSEVPAFFEFRVRYLLACERIQEAVALSKCCIQHSEVGRHLYFHQAYLTCLLKASLYDHLQKEMAMIDGKDAVEIICNTENEEKDDLLLVLCKAFLTQQLQNGDMYYIWDLIFIWSKLQLRANPSKQDFLEECHQLMSTATNVKMIFPFMKIIKAELGEEGLQFCVELCACALQMDLRHDPVTKSLVYKMIAYLLPNDLEVCRACALLVFFMERTVDSYKIVYLLYTYPDQEYHMDSSVIKNHIRFELLQILKRGLFFDPEFWNLITLKTNCLSLMSEKVMKAALNETVEDDKWIQNDSIKETYKMHSEIPDKHTSQLMNYSDKDRLPCQSARNENCVPRHRCMLCNKDFMGGHIKRHALVHLQKGNLRCVLCGKTYKQRNFMLNHLKEHLQKMKSKKRLPDTQSNENCTPVENGTSETCERDVISLPPDLKHSAAEVENHVENHNRINVNLEHVSSESQGLLKSDKNEIACAAKDQSMVQRANGSISKQKSECQKEQFRCPAEGCARSFVRQWVLVKHVKKAHPNDMKVQECTFLWTKGKCQYCQRKFLCLQHYSDHLKRHDGAHRYFCQHYSCNERFKTQAELGQHLKTHSQFQAQCSFPECFELFSDLSLLHEHECWHYSLMTNLDGTPSAAASGHNSTEASGILVKRKRKKDAQEAPIQDLKVRKESAQPKTYIPSGGGKSILNSVEVKVATPEAKSLEQPEDGAREDSAGGRVSDGQLLNGHADGDKPASAQLPEGAAQALDLQDHAPEAGKKDTGPTEIKSEGVAGKDPEKAPPPQDVSTAALKKPRRYDDEVYSYGGTSKKPFIRPPPSAYLAEQYISMPKRRKSPTKAESPSSAPQSEQAGGVQRHRCTKCFALFDKAEELQSHLAQKKCQAFFGFDSDEESKWW
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Domain:
The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function (By similarity).
Sequence:
MAHRVLVQVIFTGARVFGRAFTEAYKQTAAQMAKQGTSSAARSQGGMTNEYGGITLDESCKILNIEENGPEMNLDKVEQRFKYLFDINDKEKGGSFYLQSKIYRAAERLKWELAQREQADKGASAHPQDQQPGPQN
The following text describes a protein:
Function:
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Subcellular Localization:
Cytoplasm.
Sequence:
MKLSQFKFKLPEDKIALHPTKYRDESRLMVLHRRTGEIEHKMFKDVLNYFDDKDVFIFNDTKVFPARLYGNKEKTGARIEVFLLRELNEELRLWDVLVDPARKIRIGNKLYFGADDSMVAEVIDNTTSRGRTLRFLYDGPHDEFKKALYALGETPLPHSIINRPVEPEDSERFQSIFAKNEGAVTAPTASLHFSRELMKRLEIKGIDFAYITLHAGLGNFRDIDVEDLTKHKMDSEQMIVNAEAVNTVNRAKDKGKNVCAVGTTVMRAIESAVSTDGHLKEFEGWTNKFIFPPYEFTVANSMISNFHMPLSTLLMIVAAFGGYEQVMDAYHVALKEGYRFGTYGDAMLILDK
The following text describes a protein:
Function:
Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MLKFENVTKSFKDGNRNIEAVKDTNFEINKGDIIALVGPSGSGKSTFLTMAGALQTPTSGHILINNQDITTMKQKALAKVRMSEIGFILQATNLVPFLTVKQQFTLLKKKNKNVMSNEDYQQLMSQLGLTSLLNKLPSEISGGQKQRVAIAKALYTNPSIILADEPTAALDTENAIEVIKILRDQAKQRKKACIIVTHDERLKAYCDRSYHMKDGVLNLENETVE
The following text describes a protein:
Function:
Probable disease resistance protein.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MVDGKEVYISFNRWEDTIRHSFVSHLSAEFQRKGVSVFASEDSASDDRFAEESDAAIAKARVSVVIFSENFASSKGCLNEFLKVSKCRRSKGLVVVPVFYGLTNSIVKKHCLELKKMYPDDKVDEWRNALWDIADLRGGHVSSHKRSDSELVEKIVADVRQKLDRRGRIGVYSRLTKIEYLLCKQPGCIIRSLGIWGMAGIGKTTLARAAYDQLSRDFEASCFIEDFDREFQEKGFFGLLEKQLGVNPQVTRLSILLKTLRSKRILLVLDDVRKPLGATSFLCEFDWLGPGSLIIVTSQDKQVLVQCQVNEIYKVQGLNKHESLQLFSRCAFGKDVPDQNLLELSMKFVDYANGNPLALSICGKNLKGKTPLDMKSVVLELKRHLSDKIFVKLKSSYDALSVSEKEIFLDIVFTFRGANVDNVMQSLAGCGFFPRVGIEALVDKSFVTVSENRVQVNNLIYDVGLKIINDQSDEIGMCYRFVDASNSQSLIEHKEIRESEQGYEDVKAINLDTSNLPFKGHIAFQHMYNLRYLTIYSSINPTKDPDLFLPGDPQFLPPELRLLHWTCYPLHSFPQNFGFQYLVELNMPCSKLKKLWGGTKNLEVLKRITLSCSVQLLNVDELQYSPNIEKIDLKGCLELQSFPDTGQLQHLRIVDLSTCKKIKSFPKVPPSIRKLHLQGTGIRDLSSLNHSSESQRLTRKLENVSSSNQDHRKQVLKLKDSSHLGSLPDIVIFESLEVLDFSGCSELEDIQGFPQNLKRLYLAKTAIKEVPSSLCHHISKLVKLDMENCERLRDLPMGMSNMKYLAVLKLSGCSNLENIKELPRNLKELYLAGTAVKEFPSTLLETLSEVVLLDLENCKKLQGLPTGMSKLEFLVMLKLSGCSKLEIIVDLPLNLIELYLAGTAIRELPPSIGDLALLDTLDLKNCNRLRHLPMEMHNLNPLKVLDLSNCSELEVFTSSLPKVRELRPAPTVMLLRSKLPFCFFIFYEHRVTLSLYKARLQYIPEEIRWMPSLKTLDLSRNGFTEVPVSIKDFSKLLSLRLRYCENLRSLPQLPRSLQLLNAHGCSSLQLITPDFKQLPRYYTFSNCFGLPSHMVSEVLANAPAIVECRKPQQGLENALACSFCLPSPTSRDSKLYLQPGSSTMIILNPKTRSTLVGFAILVEVSFSKDFHDTAGLGFRCVCRWNDKKGHAHKRDNIFHCWAPGEVVPKINDDHMFVFFDLKMHPSILFEGDVFGILADLVVFEIFPVNKQEMHVGDSCTITKCGVYVINDAAGSSSGNTMTPQCSSMDSLKLLDGKGKKRLRVNYAGLKQREKALFLYIACLLGGEKADLLAQFLASTDFVIESTLEDLAGRYLIDISSNGEVMMPPLQRNFSREIIHMLPASTKELVSMASGSPCNRNNDVFVSFHGKDFRKQFISDFLKKLVYKGIRICIGDKILSRSLINKVIKESSIAVVVFSENYASSSLCLLQLMEIMKCWEELGQVVMPIFYKVNPSDIRNQSGHFGKGFKKTCKKTINDERQRWSRALTDAASIAGECSLNWASDADMIEKVANDIRKKLISSKKLGKQIQRVDCDHDNPWETEFNKCIERFFQLPYDGNHDESLVSLTTEKVIDMKQTLKEIYQITKVKLKNNLVGRRHINNICFMHILYEKCEERSSFNPTSLHTLYDNGIPYQVYTKRKKHMSGEEKAPIGGCVGCFYMGQNQGITKAGGGRTMPTAYPAAPQANQGYNAGAQPYPPTAYAV
The following text describes a protein:
Function:
Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Localizes bub1 to kinetochores and suppresses activation of bub1 away from the kinetochore.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Associates with kinetochores and centromeres during the early stages of mitosis.
Sequence:
MNFSKTLLKNSKDGISSVIFSPSVKNELIAGCWDGSLLHYQISENPELLGKYDLSSPILSLEYTDEKTALVGNLDGTVTTLDLNTRNHEFLGNHGKGVSCISKLRLENCFISGSWDKSFRVWDVRVKQPVEGQDIGKKIFASSSRDNILVLGCSERENLVYDIRNLKLPFQRRPSSFKYMTRSVCCNQNFEGFVSSSIEGRTSVEYINPSQEAQSKNFTFKCHRQIQKDYDIVYPVNDLKFHPIHQTLATAGGDGVVAFWDIQVRKRLRVLNPSKINISSISFNVDGSMLAIATCAQEEAAGNIYVHALESNFAAPKLKS
The following text describes a protein:
Function:
Involved in protein export.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIKDYKVSIAIPIALLILSILLIGFKGIPKSIDITGGTEITIKVNENMDITPLKESLNGIAEVKKLESADGYYIVIRCKNEDVDIVKQKIKEFFHVDSLDKLNYSEKTIGATLSSKFFEEGFKAVGFAFMFMAIVVYLYFRNPVPSGAIILSALSDIIMALGAMSLLGIELSSATIAALLMVIGYSVDSDILLTTRVLKRLTKSFDETVKEAMKTGLTMTLTTITAMLILLIVVKLFIPVADILANIATVLILALIADIINTWLLNAGILKYYITEYRAKKI
The following text describes a protein:
Function:
Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress. Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome. This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy.
Subcellular Localization:
Cytoplasm, Stress granule. Note=Colocalizes with TIA1, G3BP1, VCP and 26S proteasome in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment in a VCP-independent manner. Not localized in SGs in response to other heat- oxidative- or osmotic-induced stress treatments. Colocalizes with VCP in cytoplasmic speckles.
Domain:
The ubiquitin-like region is necessary for its localization to stress granules (SGs) in a VCP-independent manner. The AN1-type 1 and 2 zinc finger domains are necessary for the recruitment of the 26S proteasome to SGs. Both the AN1-type 1 and 2 zinc finger domains and the ubiquitin-like region are necessary for efficient SGs clearance upon specific arsenite-induced responses.
Sequence:
MAELDIGQHCQVEHCRQRDFLPFVCDDCSGIFCLEHRSRESHGCPEVTVINERLKTDQHTSYPCSFKDCAERELVAVICPYCEKNFCLRHRHQSDHECEKLEIPKPRMAATQKLVKDIIDSKTGETASKRWKGAKNSETAAKVALMKLKMHADGDKSLPQTERIYFQVFLPKGSKEKSKPMFFCHRWSIGKAIDFAASLARLKNDNNKFTAKKLRLCHITSGEALPLDHTLETWIAKEDCPLYNGGNIILEYLNDEEQFCKNVESYLE