lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Key component of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. RqcH recruits Ala-charged tRNA, and with RqcP directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal alanine extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits; Recombinant protein binds to immobilized human fibronectin; binding is saturable and competed by heparin. Recombinant protein inhibits binding of whole cells to fibronectin.
Subcellular Localization:
Cell surface. Cytoplasm. Note=Found on the cell surface in the region of the capsule in capsulated bacteria (strains NCTC 10319 and R36A).
Sequence:
MSFDGFFLHHIVEELRSELVNGRIQKINQPFEQELVLQIRSNRQSHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEMTVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGSTYIAPPSTESLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEKLSAFRNFFNQETKPCLTETSFSPVPFANQAGEPFANLSDLLDTYYKNKAERDRVKQQASELIRRVENELQKNRHKLKKQERELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILDNYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVETVLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQNEELTFKMARKEELWFHAKDIPGSHVVISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQVDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKIASMKKS
The following text describes a protein:
Function:
Functions in nuclear protein import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF
The following text describes a protein:
Function:
Catalyzes the attachment of aspartate to tRNA(Asp) in the mitochondrion.
Miscellaneous:
MISCELLANEOUS: Present with 1550 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLARSRVCLQTITRRLADFPEANAIKKKFLFRKDTSTIKQLKGLSSGQKIVLNGWIEQKPKRVGKNLIFGLLRDSNGDIIQLVDNKSLLKGFTLEDVVQAVGILSLKRKLSNEDADEYEVQLEDITVLNASNKKPAQMQDFKLSAIYPPEFRYLQLRNPKYQDFLKKRSSISKEIRNSFNNFDFTEVETPMLFKATPEGAREFLVPTRTKRSDGKPSFYALDQSPQQYKQLLMASGVNKYYQMARCFRDEDLRADRQPEFTQVDMEMAFANSEDVMKIIEKTVSGVWSKFSKKRGLLTLDSKGTLVPAKKENGTVSIFRMTYEQAMTSYGIDKPDLRAPDLKIINLGEFNAFSHLNKKFPVFEVIILRSAFSNMEEYKERWSFLTNNSNYNYRVPIVLPIENDEQANSNWFENFHAIATFENPHLITKFLKLKKGDIVCGCTREPNHSIFENPTPLGRLRQLVLQSEHGKNIYHAVNKDVASWIVDFPLFSPVIIEDKSGKKEKLAYPEYEKDRLCSTHHPFTMVKLKDYEKLEKTPEKCLGRHYDLVVNGVELGGGSTRIHDPRLQDYIFEDILKIDNAYELFGHLLNAFDMGTPPHAGFAIGFDRMCAMICETESIRDVIAFPKSITGADLVVKSPSVIPESILEPYNIKYSNSKK
The following text describes a protein:
Function:
Acts in transcription regulation. May bind to a MEF2-like typee II promoter sequence.
Subcellular Localization:
Nucleus.
Sequence:
MGRKKISIAPITDDRSRSVTFVKRKQGLYKKAYELAVLADCEVAVTVIDRKGRLHVFCSSDYQRTLQQLNTLSIYELKNRSHFSSSPVEESSTVSPETTTGSFTPLNNKHLKSQDQPLSDSQLDTGDSPATSETTVQDYNPQVQSYCRPEPLSSNHVRSCPPFPPTQHHHPHTRPPHHPPHPHFHNNNYPPPYCFQSPVSPGATVPLQHHSPYPSDNGFPGHRRQTHFAPYYYPQRATSPSLKQVPTYLGTHVLQQDQSTYDQKVLMPPASYLSSPNQYTLKNVSPGNPACPPFLYEHPNPQLTPEMFDVKQGSPIPPTAYSGSSCETSQHTIANTPFLAYDRSPSLTNQEAESSFQDVASISPHSLSDVKY
The following text describes a protein:
Function:
In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MATKDKRSSPPNHPPDPFLEKTVANWGSILDSVKDQLPSLDSDSSSSDYDDEELFIFQRDEATLIPDLSEELADLSPDVLDDQQRQETIKKLREAWIGGQEVSAIPQKDIIQPLKIRWPSQDSKAADALLRIPEETPKWQKGDSLEFSEPSTVKDLTEGPQGEEDATQSGERGQATDHFCFDISPLTEDSELLNWKTTRREREKMIKTTILHKETLKPPLGVLEKPELTKCLPSKSVDDQVEQSTGSEEEQEAMSDKKAKGLTLLSFQELNQLDLDRILRSLKEQEDWGDHSGGPSCSAADPTRSQESLAAKSQDKLMEQLVNLCAKQSKAMSSCYMEPTDKLCSSKELQVRRSRGDSFLPTWPSQGLHEGLHLRGKPEPPTVFIDLRTSLLQKSEQDPQEPWKDPSSSYCSSDRGEEEQEDEEDEEDEEDEEDKEEETQLLKEEEKQKRVLLSSPSPSRDYTGKSLLLRQLRAFRNKISQP
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDDGAQVAEPEGKGKAFSFPNGALRKHHQRSPPVVEFSYRECLKNHAASLGGHALDGCGEFMLSPAADPADPSSIRCAACGCHRNFHRRLPGPLHRRHRSNDQEGGGGDEDGEGEDDEEADMDGGRVHPWPHLSSTSPPLFYPSAPHMLLALSAGLPGGPGPIPVAAPIAAVAAPAAAAESAQPKKRFRTKFTAEQKDRMQEVSERLGWRMQKRDEVLVEECCREIGVDKGVFKVWMHNNKHTFFGQARRGEADGDQAGSGGAVGDNDVGRIEASGQSANGVEDGGGGNGHPANGSPSPS
The following text describes a protein:
Function:
May play a role in genome packaging through direct interaction with viral DNA. Binds to ssDNA and dsDNA with the same apparent affinity in vitro.
Subcellular Localization:
Virion. Note=Found in association with the viral nucleoid.
Sequence:
MPTKAGTKSTANKKTTKGSSKSGSSRGHTGKTHASSSMHSGMLYKDMVNIARSRGIPIYQNGSRLTKSELEKKIKRSK
The following text describes a protein:
Function:
Has antimicrobial activity against Gram-negative bacterium E.coli ATCC 8739 (MIC=3.1 ug), against Gram positive bacteria S.aureus ATCC 6538 (MIC=3.1 ug), methicillin-resistant S.aureus ATCC 43300 (MIC=12.5 ug), B.subtilis ATCC 6633 (MIC=12.5 ug) and against fungus C.albicans ATCC 90028 (MIC=50 ug).
Subcellular Localization:
Secreted.
Sequence:
MFTLKKPLLLIVLLGIISLSLCEQERAADEDEGTKIKRRIFSKIGGKAIKNLILKGIKNIGKEVGMDVIRTGIDVAGCKIKGEC
The following text describes a protein:
Function:
Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. Proteolytically cleaves and therefore activates TMPRSS13.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MNGCEEGVEFLPANNSSKVEKGGPRRWVVLMAVLAAFLALSLLAGLLAWHFQDRNMRVQKIFNGYLSVRNENFLDAYENSNSTEFANLAKKVKEALKFLYSGIPVLGPYHKTSTVTAFSEGSVIAYYWSEFDIPKHLVKEAEQAMAEKRMVTVPPRARSMSSFVMTSVVAFPSDPRIIQNTQDNSCSFALHAQGSEPIRFSTPGFPDSPYPSHARCQWTLRGDADSVLSLTFRSFDVATCDERGSDLVTVYDTLSPVEPRAVVQLCGTYPPSYNLTFLSSQNVLLITLVTSTERRHPGFEAVFFQLPRMSSCGGYLRAAQGTFNSPYYPGHYPPNINCTWHIEVPDNKNVKVRFKAFFLQEPNVPVGSCTKDYVEINGEKYCGERPQFVASSRNNKITVHFHSDQSYTDTGFLAEFLSFDARDPCPGSFMCNTGRCIRKELRCDGWADCTDYSDELDCKCNATYQFTCRDKFCKPLFWVCDSVKDCEDGSDEEGCSCPPNTFKCGNGKCLPQSQQCDRKDDCGDGSDEAKCQDGKAVPCTEHTHRCLNGLCVDKSNPQCDGNEDCTDGSDEKDCDCGRRSFTRQSRVVGGENSDQGEWPWQVSLHAQGHGHLCGASLISPSWMISAAHCFVDDRGFRYSEHSVWTAFLGLHDQSKRNAPGVQERGLQRIIKHPFFNDFTFDYDIALLQLDRPVEYSATIRPICLPAADYTFPTGKAIWVTGWGHTQEAGQGAMILQKGEIRVINQTTCEHLLPQQITPRMICVGYLSGGVDACQGDSGGPLSSPEEDGRMFQAGVVSWGEGCAQRNKPGVYTRLPVFRDWIKAQIGV
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIELLIMVIKTTVVFGIVLTHVAYTTYAERKIIGRAQARMGPMEVGPHGLLQPIADFIKIFFKEDIVPINAEKFIFQIAPLIVLIFTMINLTVIPFTSNFILADLNVGLLFILASASVSVYGIILAGWSSNSKYSFLGGLRSASQVLSYEIALGLSLAGVVLAAGSLNLRDIVIAQHNTALGVYAIPQIIGFVVFVIAAFAETNRAPFDLPEAETELVAGYLTEYSAFRYALFFLAEYVAMYIMASLCALCFLGGWTIPKFITDILPFLDKVPGIIWFAIKVYAFIFLYIWVRATFPRYRFDQLLNIGWKVLIPAGILNIIIIAIFKRFAL
The following text describes a protein:
Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
Subcellular Localization:
Nucleus.
Domain:
The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex.
Sequence:
MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQDILGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPKQAPFRSPTAPSVFSPTGNRTPIPPSRTLLRKERGVKLLDISELDMVGAGREAKRRRKTLDAEVVEKPAKEETVVENATPDYAAGLVSTQKLGSLNNEPALPSTSYLPSTPSVVPASSYIPSSETPPAPSSREASRPPEEPSAPSPTLPAQFKQRAPMYNSGLSPATPTPAAPTSPLTPTTPPAVAPTTQTPPVAMVAPQTQAPAQQQPKKNLSLTREQMFAAQEMFKTANKVTRPEKALILGFMAGSRENPCQEQGDVIQIKLSEHTEDLPKADGQGSTTMLVDTVFEMNYATGQWTRFKKYKPMTNVS
The following text describes a protein:
Function:
Plays a positive role in plant adaptation to phosphate starvation. Inhibits PHR1 DNA-binding activity in a Pi-dependent manner.
Subcellular Localization:
Nucleus.
Sequence:
MKFGKSLSNQIEQTLPEWQDKFLSYKELKKRLKLIGSKTADRPVKRLRLDEFSVGISKEEINFIQLLEDELEKFNNFFVEKEEEYIIRLKEFRDRIAKAKDSMEKMIKIRKEIVDFHGEMVLLENYSALNYTGLVKILKKYDKRTGDLMRLPFIQKVLQQPFYTTDLLFKLVKESEAMLDQIFPANETESEIIQAELSEHKFMESLHMKSTIAALRVLKEIRSGSSTVSVFSLPPLQLNGLDETWKKIPLLEQEAK
The following text describes a protein:
Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MKFRAKIVDAACLNHFTRVSAMIAKLAKTCTLRISPEKLNFVLSDRAASAGVSMWCELEQENFFSEFQMEGISAENNAIYLDLTAENLSRALKTAQNARALKIKLTNKHFPCLTVSIELLSVSSSSRVVTHDIPVKVIPRKLWKDLQEPTIPDSDVSIYLPALKTMKSIVEKMKNISNHLIMEANLSGELNLKIETELVCVTTHFKDLGNPPPASEDASQERPPEQMAEVHIDIRKLLQFLAGQQVNPTRAVCKLHANPVPFTSPAKVSHPPGALTFGEEAQVLENPPPLASWDQVRPESSHPHVSGELELCFQKMQAWPVQPGKACLVRQERITLAFSLV
The following text describes a protein:
Function:
May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MSVHFDERSGVVLCQTPWGCWSQTMEEIFIEVNVPEGTTSKEIQCKLGSRDVSLIVKGKDVLKGKLFDSTITDEATWTLEDRKLIRIVLTKTNRDAGNCWSSLLEGEYSADPWIQDEMQKKLTLERFQRENPGFDFSGAEISGNYSKGGPDFSNLQK
The following text describes a protein:
Function:
Involved in heme d1 biosynthesis. Radical SAM enzyme that catalyzes the removal of two propionate side chains from the intermediate 12,18-didecarboxysiroheme (DDSH) and may introduce the keto functions on rings A and B, yielding the heme d1 precursor dihydro-heme d1.
Sequence:
MLRISHYLRSLTEDAPTPRRAGGRRAPVVIWNLLRRCNLTCKHCYSTSADSDFRGELETAEILRGIDDLRAAGVRVLILSGGEPLMHPDLFEIAAHARQAGMFVALSSNGTLIDEGNIQRVAEARFDYVGISLDGLRETHDRFRQKQGSFDAALAAMRLCREADIRVGMRTTLTEENAAQLPALLDLMRELDVQKFYLSHLNYSGRGRRSRALDAHHRRTREALALLFERADQDIRQGRDSDFVTGNNDADAILLLDWLKRRRPQQLARLCELLLDWGGNASGEGIANIDNTGEVHPDSYWWHHSVGNIRHQRFADFWFERPDPLLLQLRQRPRPVVGRCSQCRWLDICNGNTRTRAWAGGELWGEDPGCYLSDQEIGLERIALHAV
The following text describes a protein:
Function:
Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade.
Subcellular Localization:
Secreted.
Sequence:
MKVLVVFIFCLVRSTFGQFEVPDALVEVFRPRGLRVSIPDQEGIKLFAFHGKINEEMNGREGGTFSRDILKAKNGRWTFYDANARLKEGDILYYWTYVDYFDGKNKLGYPNDDQKFVVKQLLDKDGAAPSVTPPTVTKAPPQEHTTLESGCKASVTTKVNERVCAGEQIFHEDFTTFETNIWRPEVKFADKPDYEFVFYRAGPPNLQVKHHRLTIRPVPSDAVFGEGFVSRREKVNLAPACTGVHGSIECVQTPGAFLILPPVTSAQISTKGKWSFKYGKVEIRAKLPKGDWIYPELYLNPVNEEYGPGYASGQIRIAFSGGNEDLCRDLRGGCILGSRPAARNYAVKNIVKNSGSWSDDFHKFIVIWKPDQITMMVDDQVYGNIYPPEGGFVSEAYNLDLVNVERWRGGTSFAPFDKEMYLVLGVGVGGHCFEDRSDATKPWTNNDPKSQKKFYQAAAQWGATWSNASRLEVDYVKVSAL
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MPKCPFHKIVSSTTGDNLLFVSGSKFLLVDSNNGSILAAVGATEKEVTDQYPDAEWISQNLLFNQSISGIGWHQSSNTLAITNNNKDMQLWRRIPGKSWNLLNTRPIIKKTQCILFSPCGEYVFLGDKFGDVYRNAVEDPKKPAELILGHVSMLTDMSWSQDGKYIITADRDEKIRVSKYPHAFDIERFCLGHEQFISRILVLSNVVVSGGGDPFLIVWDYLAGTILQKLTVLDDKVDMKNTSVLSIEYCHTFKLIAVIFEHLNTVLIIDASNERKLVIKQSLETIHHPVDICFDRSGKLWMSVVAPDNEPSVYISEYIDEKYTALISTHNLLMDELPLVFEFHKLRKWSGTSSYHDQKNAQKKQRDEVFAAGKKRQNPKEAFKPKNGTMKESDDAQPPKKKTKRGGKGKLVSEQKNTLDKVESSPDPAVV
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSVLKKDSTSEKRTQLESILEERNNKLTQLFWLSRLNELKSGGDLQSVRQELAEFLVQNDLTKNLTFDISSLRTYRPQEPPMDRRPLRSKSSTPLENGTINRKREDAEPHMEETRKRLREHIIPEEDDDREHEQRPVKLQKVGLSHDEELPKRLEPPTIPIRKISSAGDNQETGSVIGEKKSEQPVSTSRNRPIHTQLSTNPFYQHMDISTLRAEPTPVEVKRKRNYIIDEIIKTQSKSTDTSDSHSTAGGRDSVYLVMKETVPSKLARAIPLSELKYVSQTLPLIRLIPPTHKALTTDLYNTALNEGRITVVSSRIEELRRLNLWSLRQPKKFLDPWRQKQPSTHRGYMLEEARWMREDFHEFKKFKVSVCAVNSKAIMDYWKYGKACCIKRRSISHLQKSVNEVQEADTLGNIDDLLNKISDKKLAGMIEEQKKVIAVDAKLSSSKIAPSEEIHAPHIWEDPLDELDEQGCKPIFKTYMSYNGVSPLEKTILEDLPIYKGILDEQAAEDNSVPFVPISKSTVLLDDDYFMKLIEKDIVDDEPSFVALSKRRGMFYGNRRSHYLKPPSAPALRYLKFRTPTIWSPEDDQELVKNINQYAYNWDLIGALVSSSNGRSYISNIERRTPWQCFERFVQLNEKFSVHDMKGPRANAAQMWLYEAHKLQQQQKRRISPLGVGSESIQRGHRRLRWATMFEAMRKTIKKRENAPRPNPSQPRKPLDVKSAAVPTPAEMSELKAQRDETLRREGQMRRAAKQRIHLAQLQQQQQRVQQDVVQQRPQSRSQPDPPLSQQIPRVQSPRPQQPLAQQLIEDKGKLLPGVSVSAPTSKEASNNGKNLMALRQVQSSPVNGDLQKATAQVPPRGPNKPLTEKEIIESYARKIIAQKPDFTPELALKAAESYYQNVTLKQNTIGKQIVSQPLSAATVSTPPSNGRAVHKIRSPTPQEILQRIQQKKNDS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine.
Sequence:
MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQNTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRVIVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKAAEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAALTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSKLKIIVSTTSLLCTRIEWTLKLKGFEDGMIVEDWRKQKSELLSKSNPVHKKVLVPLDDGVAIAKSKVILEYIDEKWKGGDPFPLLPQDPFQFVSGISLLEEKATLLTIFPQVIVFSPACVVLFTSCSLEFSILLILSITFLRSHARSMHTRERERERVLLRQECGGEPY
The following text describes a protein:
Function:
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
Subcellular Localization:
Cytoplasm.
Sequence:
MQRGIVWIVDDDSSIRWVLERALTGAGLNCVAFDSGNQVLDALATRTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQQQPARSQPVSGPTADIIGEAPAMQDVFRIIGRLSRSSISVLINGESGTGKELVAHALHRHSPRAKALFIALNMAAIPKDLIESELFGHEKGAFTGANQVRQGRFEQADTGTLFLDEIGDMPLDVQTRLLRVLADGQFYRVGGYAPVKVDVRIIAATHQNLELRVQEGKFREDLFHRLNVIRVHLPPLRERSEDIPRLARYFLHVAAKELGVESKNLHPETEAALTRLPWPGNVRQLENTCRWLTVMAAGQEVLVQDLPSELFETHMPDASGQRAPDSWSTLLAQWADRALRSGHQDLLSEAQPEMERTLLTTALRHTQGHKQEAARLLGWGRNTLTRKLKELGME
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MENKKTPATPKDVFGGGGKSEEGKKPEEGAMLKALLAQEEIDSLENPQPQPLRILGESSPNTHTYRLYSKGLVSEEIVKDVTKLVGGSGLFLCDSNGNSSATNKVLRDHRVLAQPEAVELAAIIQGLDWALKHGVKSIQFFCEDDSIILDYVIGKAAPPNESIVVAKLLKQLALLQTSFTSCQALPLLRSDDINSSLIKLARDAIASQTTWQREDGVVVEACVICYEDVPADTKFTVSGCFHRICFECMRNYITHSLRHRSRLICPNTGCKSELKPADCNRIADPDQLALMVERKAEETIDVSDRVYSPNPRCSILMSARGLPVVDPALTGARKCLGCGLRFCVNCKMEWHTKLSCAEFRKTKAYTKSGTAVFDATARELGLKKCRRCLCTVERAEGCKHMTCTFCKYDRDLPLGYCPKPSCNFLMSDRDLPLGFSIDPRQKSVARTCVECGLCFCKKCHVPWHYKKTCDEFKKSPSYLTSDAALFESLVKTQGWIKCPQCATVVQKNGGCQRISCRHCNHKFCYACGAACTRKKMSCNCSPEDGPSKMSSSSGESHKTRLLRA
The following text describes a protein:
Function:
Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.
Subcellular Localization:
Secreted.
Sequence:
MHTVLYSNMKNMFQLLSFLCVSLLVAGDVHHHAACSTVCSLKGILDSVSDLTDLAKERLATLQNPICSKDKAFYMETYTNVTQNKAEKNGLPINCATVYQQGNRTSGIYMIWPLFLNHPISVFCDMETAGGGWTVIQRRGDFGQPIQNFYQTWESYKNGFGNLTKEFWLGNDIIFVLTNQDSVVLRVDLEDFEGGRRYAEAVEFLVRSEIELYKMSFKTYKGDAGDSLSQHNNMPFTTKDRDNDKWEKNCAEAYKGGWWYNACHHSNLNGMYLRGPHEESAVGVNWYQWRGHNYSLKVSEMKIRPIIFVPGEGLPK
The following text describes a protein:
Function:
Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates (By similarity).
Domain:
Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
Sequence:
MQTENQVNDLYPIAVLIDELKHDEITYRLNALERLSTIALALGPERTRDELIPFLDESIDDEDEVLSALADQLGNFVDYVGGPEYAHVLLSPLENLAATEETVVRDKAVDSLNKVCICLSQEQLEQYFVPLVQRLSTAEWFTSRASSAGLYCAAYSQSENPAVKVSLRQSFSHLCHDEAPMVRRPAATNCAKFVFLVTKQEAIDEFIPLFNSLSNDDQDSVRLLSFDIMVSLAEVLKSDSEIRHYLLQPLRSFVSDSSWRTRYMVAANFVKLAKVVGPSLIKDELIKPFVLLMKDTEQEVRRAIATQIPGFCELLDKRIVLEEIIPVIQELINDPAQHVRAALGMNIGALAPQLGKEKTTEYLLPMFLELLKDENPEVRLNIISKLEVVNKVVGIELLSQSLLPAIVTLAEDKQWRVRLAIIDYIPLLAQQLGVEFFNEKMGNLCMSWLEDHVYSIREAAIKNLRKLTEIFGLEWATETIIPKFLAMRSHPNYLYRMTTIFAISEIAPALNAEVIEKQILPTLEQLVNDPIPNIRFNVAKAFEVLKPVLAAGGDSTVYEQQIIPLLEQLTKDNDPDVQYFATQALEQTND
The following text describes a protein:
Function:
Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.
Sequence:
MAGGEDRGDGEPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQVSPSGYYLDTELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYSSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSDTIQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIRAVNSVASTTGAPPWANLVSILEEKNGADPELLVYTVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRHLGTAGTDVDLRTQLVLYENALKLEDGDIEEAPGAGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLNVESVEAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPPPPPLPLAAPLPHSVPDSSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSVDTARLEHLFESRAKEVLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEKFSGVAGEAPSNPSVPVAVSSGPGRGDADSHASMKSLLTSRPEDTTHNRRSRGMVQSSSPIMPTVGPSTASPEEPPGSSLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKGPGLEV
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MKILRIIQGVGTQLRSLSMVFSHAWHPRETLNYPEEAVYAAPRYRGRIVLTRDPDGDERCVACNLCAVACPVGCISLQKSERDDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEYRRQDLVYEKEDLLISGPGKYPDYNFYRMSGMAIDGKPKGDAENEAKPIDVKSLLP
The following text describes a protein:
Function:
Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.
Sequence:
MSDVLSQYKGCSVRDLPTPNFVINEEKFDKNCTTMLNNVEKLSQECGVPIKFRAHVKTHKTAKGTLKQLGHGLPLAKRTTRAILVSTLKEAEELLNYQDRQCSDYIDDITYSLPCCVPEFIPLLSNLSRRVNNFQVFVDNIEHLENLKNFGRPASGKKWSVFIKVDMGTKRAGLAFDSPEFLSLLKKLTSSEIKEVIEPYGFYAHAGHSYSSTSINDTQNLLMEEVKAVNSAAKVLCSVDPQFDPSKLTLSVGATPTSNSLKLDNKSTLVKFITTQLVSTLEIHCGNYCMYDLQQVATGCVQDHELSGFVLGTVLSSYPSRGELLSNTGVMCLTREASSIKGFGICADLEHVLKSESFSREWYVARVSQEHGILRPIRNWNETTPLKLGSKIAVLPQHACITMGQFPYYFVVNSEGIVNDVWLPFQKW
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MESFTRAELVAQRDGVWAVCGEVFEAYEKCRMEKGSDPELCLRESTAVVGCSQKVMREIVKNCQKELNESVKCIEENNMRTIPCEEENKAFNECFDKLVAPKFL
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MFTLARVLNNIGSASSNEPIPYCLICSEVADGNHFGVAAACRACAAFFRRTVQHNKIHECGRNGQCFFLSCKFLLVGFQISPLSSDARSMCKACRYGKCLEMGMQRSSVQQRREQLGKRLNISDDRGKPVLNKLRRAYEMLILNRKHVHNRRENQAPRAIGFNELPIVFQNESTSIYQFLWEAFPEYSMLLPDTKLAFFKNFFLSFCLFESSFNGCSAKQKNVMLIPSGDYIDLAHSESFFTNDHQTFTERDNIEILAQRLKLIQSSITVPLSAENVDIYEFLALAGIILLESDSESEADFQEEAVKIKSNIIKDLLFHYQCINIYDDAAMRLGAVLSILPSIQVCCSRSNNFLIINSKDVSESQSPFSRIHGNQKYAQFVRSSQESLRHVLANFIKFICKFVSI