lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Nucleus.
Sequence:
MNLLSSFPPPAEGVRRLQPGTEAVVGGRGLGAGTLYIAESRLSWLNSSGLGFSLEYPSISLHAISRDTAAYPEEHLYVMVNSKLGDKEDKEAPMADQEEEESEDDDDEEPITEIRFVPAEKSDLGEMFSAMCDCQALHPDPEDADSDDDFEGDEYDVEAHEQGQGDVPTFYTYEEGLSRLTTEGQATLERLENMLGNSIGNQHTMAGVRTEGSGLEPEDGMDVETAPTVAGQFEDADVDH
The following text describes a protein:
Function:
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable). Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with the chloroplast NAD(P)H dehydrogenase/photosystem I (NDH/PSI) supercomplex.
Sequence:
MSSFTTTNTPPPYLLRKIYHRRVNQPFSVVCCTGEPQQDIFTRRRTLTSLITFTVIGGATSSALAQEKWGTRSFIKEKYFMPGLSPEDAAARIKQTAEGLRDMREMLDHMSWRYVIFYIRLKQAYLSQDLTNAMNILPESRRNDYVQAANELVENMSELDFYVRTPKVYESYLYYEKTLKSIDNVVEFLA
The following text describes a protein:
Function:
Activated enzyme phosphorylates target proteins and initiates downstream signaling pathways that shift metabolism from anabolic to catabolic pathways. Acts as a highly sensitive cellular energy sensor.
Sequence:
MSSYQQNPIGSFGGLYGSGGIEKSSQIIGNYRLDKTLGIGSFGKVKLAEHIRTGVKVAIKILNRTKIKNLKMDEKIRREIQNMKLFRHPHIIKLYEVIETTTDIFMVMEYVTGGELFEYIVKNGKLLEDESRRLFQQMISGVDYCHHHMVVHRDLKPENLLLDPINKCIKIADFGLSNMMQDGDFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYAFLCAKLPFDDESIPMLFKKIREGVFSIPDFVSPSCADLIKKMLVVDPVKRITIHEIRNHPWFQVKLPKYLSSPHTFLSKSIQTINNSILNEMVQVYAPIDRERIIEELQKSGEVNDLIVSYHLLVDSKRGSYENEINSPNLVSPITTPIMSSAQKSPIMFTTTTGFNPSNSNSISNNNNNNNNNNNNTTNNNNNTTNNNNSIINNNNINNNNINNNNNNNNNNINNNNIINNNNNNNNNNNNNNNNNNNNNNNNNNNSSISGGTEVFSISPNLNNSYNSNSSGNSNGSNSNNNSNNNTNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNCIDSVNNSLNNENDVNNSNINNNNNNNSDDGSNNNSYEGGGDVLLLSDLNGNNQLGGNDNGNVVNLNNNFQLLNSLDLNSDIQTQPHRKWYLGAISQLPPHEIMGEIYRALKKVGFEWKLTGPYQLRCRMVNGKPIKLVLQLFRVAENRYLLDIKKIEGEIFIFFDICSLMLEELNL
The following text describes a protein:
Function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MMGNKVPYQKLDMAANDDVIPPVDPEKGAEIFREHCAGCHDIDKSGEHRAGPNLMGVWGREANTIEGFAFVESDEKKGVIWGDKTIYDFLEKPHIPGTKFIFRELRGKAEEKANLVAYLKKTTDPRIHDRVKLAFLLTLDGKIAMVTGRHHLELHYCHYQSIL
The following text describes a protein:
Function:
Required for normal root and shoot development. Prevents constitutive production of a root mobile carotenoid-derived signaling compound that is capable of arresting shoot and leaf development.
Miscellaneous:
MISCELLANEOUS: The mobile signal produced in absence of BPS1 is neither abscisic acid nor the MAX-dependent hormone.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MARPQDPPRGFFPFGNPFKNLSSKNSVLSSKLLPLLNNFETNLASSISKLVPKEKSDILTVSWMKQAMESLCETHNGIKTLITDLELPVSDWEDKWVDVYLDISVKLLDLCNAFSSELTRLNQGHLLLQFALHNLEANSPQNLSKAQSSLDSWKQHIVSKNPRIENCRAILSSLVQTLNLPKVKNSAKGKVLMRALYGVKVKTLYISGVFAAAFSGSSQNLMYLTVSNELPWAQSFMEVQNTMNAEIKNIFLSDGLTVLKELEAVASGVKKLYPAIQQGSIDPISLQPLKDSVTELSNGIDLVSKEVDCFFKILLSGRDTLLENLRSMGASTLQATSPKKAAGKNYRGF
The following text describes a protein:
Function:
Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting.
Miscellaneous:
MISCELLANEOUS: Present with 3400 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSVKPIDNYITNSVRLFEVNPSQTLFSISYKPPTQKTDTKVSFRTHNSHLSLNYKFTTNKSKDVSRLLSALGPRGVSITPGKIEKIAQSKKKNNKIKESSKKIKGKSIQDIVGLATLIVNTDVEKSDPAAKKTATEPKQKANAVQNNNGNSAASKKKKNKNKGKKKR
The following text describes a protein:
Function:
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
Sequence:
MNQTLNSSGTVESALNYSRGSTVHTAYLVLSSLAMFTCLCGMAGNSMVIWLLGFRMHRNPFCIYILNLAAADLLFLFSMASTLSLETQPLVNTTDKVHELMKRLMYFAYTVGLSLLTAISTQRCLSVLFPIWFKCHRPRHLSAWVCGLLWTLCLLMNGLTSSFCSKFLKFNEDRCFRVDMVQAALIMGVLTPVMTLSSLTLFVWVRRSSQQWRRQPTRLFVVVLASVLVFLICSLPLSIYWFVLYWLSLPPEMQVLCFSLSRLSSSVSSSANPVIYFLVGSRRSHRLPTRSLGTVLQQALREEPELEGGETPTVGTNEMGA
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVAPGRMVTSSRRIGRVTNKTKLIIYRGSDKVDTSAAETVLWDQEAGGAGKDSNKHQHIGATGVESGELLEHHLQAALSSASLLHSSNKPSSPKSVKEAPAAALNYHIPTPDATGLVSDTVFSQLYQRTKYVEPYNFIRFSDTVEESSCGWGGLGYCMDDADERWLNDFNSKAEGSSGDVKSDKEQGRGMRVKGKDREKEKGDAPAPLVISEDMFEYIMGVFEKYTEENAPMLHTDLSLLPPFSAVENMFSTPISPAFLPSNEIPKELGDLKACARMARNVYPHWKSRREQRQGKSILPQLNYDETNDNDPYVCFRRRDIRATRKTRRTDNFSIEQFQKLQFELRSAHALADRVLTREREKKSLYEAEKELWEARWKFFETKRRWPSLGMTSDEEHKITGRPTIVPPIQIPSLSGQTPLTSGQSSSHMRKRTDKDREERAQRERYDAQRNAERSGILSGRSNAPDALKERLQALQQKTEEMLARKKEQDAHWDDSIDSPYQPLPPSNSVHAFRSLFVLDPCRAQCKDSETGNEILHPESFRIRRGRGGIVRLDRRTSIYSHRRGIQPTSPSEYPTWLFPDIAPRRSEKKRPRSIDEVEEEMQEQSPKVMRKDLNETWRYDVDRGGAVGVGMGLEEDYDRVIIDDLEAKYIRHRISLLQESDCAKLRPDNYILDQTREALDAAADAKPPPAPIFQKPPAPQPNPQLLAAHLQQQQMLAQQQQMEQFQRFQLMAQQQAMAQAQAQAQAQAQAQAQAQAQAQVQAQGQGHPQAHLQTHPQGVPQPNGVNSPMPNGQQMLPPSDGVKQLKLPPHAVARLGAAMANANANANGGLHVLQQQQQQHAQTSQQ
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate. Participates in the pyrimidine biosynthetic pathway.
Sequence:
MEWPINKPIYDINKSWEDNLENGPFIEGYKKVDRNDNKDPSKYIDFLGQKLASPIGVPAGPLLNSQWVKFALEAGFDLPTYKTIRSHEHFGHPVPNVMYLDLESEDKQFTKSDSGSTLHATQTIPTTMDQLAITNSFGMPSMGKEYLYKDIALAHSYLGSGQSMIVSITGTASSAHDFLQDFVDTVRIACDAGAKMVEVNYSCPNVVTGEGQIYHNPDAVYEISSTLVKELSSKNIPLIIKVGVMDDLEKMERLFQQAERAGVAAIAGINTLSMKVTDKITGEPSLGASRLTSGVCGAPIRSAALDWVSTASSIIKKQNSKLKLLGCGGIVKPEHFDDFLNSGADIAMSATGLMWDPYIAMKWHNNNKNN
The following text describes a protein:
Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain.
Sequence:
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSSSMDLSFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTVYLSPPADTSWRRTNSDSALHQSTMTPTQAESFTGGPQDAHQKRVLLLTVPGMEETGSETDKTLSKQSWDSKKAGSRPKSCEVPGINIFPSADQENTAALIPATHNTGGSLPDLSTIHFPSPLPTPLDPEEPPFPALTSSGSTGSLAHLGVGGTGQGMNTPSSSPQRRPAVVSPLSLSTEARRQQAQQVPPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPVSQQQPPPPQVSVGLPQGGPLLPSASLTRGPQLPPLAVTVPSTLPQSPTESPGQPPMGIDVTSAPALQYRTGAGSPATQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMTARQANALSRQLEQFNMMENAISSSSLYNPGSTLNYSQAAMMGLSGSHGGLQDPQQLGYAGHGGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL
The following text describes a protein:
Function:
Calcium/calmodulin-dependent protein kinase. Required in nuclear division cycle for progression from G2 to mitosis. Required for hyphal growth.
Domain:
The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
Sequence:
MSFANMFNKLSGQPESYEKKSLYRFGRTLGAGTYGIVREADCSSGKVAVKIILKRNVRGNERMVYDELDLLQKLNHPHIVHFVDWFESKDKFYIVTQLATGGELFDRICEYGKFTEKDASQTIRQVLDAVNYLHQRNIVHRDLKPENLLYLTRDLDSQLVLADFGIAKMLDNPAEVLTSMAGSFGYAAPEVMLKQGHGKAVDIWSLGVITYTLLCGYSPFRSENLTDLIEECRSGRVVFHERYWKDVSKDAKDFILSLLQVDPAQRPTSEEALKHPWLKGESASDRDLLPEIRAYIARSRLKRGIEIIKLANRIEALKMQEEDEEDIPSAVDVQASEASDKSGLSPFPALSTENSNTHPASTGNGESGGTKKRSLSKIARGAIFREVVLAKVREMKENEEREKVEREARERAHS
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MPSAGIVSSSAAAFLLLLFVLLGEGQPAEGFMSKNGSEAFLAPEPEVRYCYRRSVTDGEAKLTKTVAVGPIELGLGAVPTSKTTAVPADTQAPTPPALAPPAAETGLSWRAKAWCCWVLAVATVVLVFVVRPETFLVSPRIDGMFITDGEGDPPVDGNQHTTMDMDTVPDILKVSVDSSETRRERGSSPMPRPQPRDPMLIADSNGDSPVDGHHAYDGRGELFYCPMCMETAPIILKSRFGSCDDHVFCSSCVAKYVAVKQRQDVALPVECPDCKDDASLNSDGEGNEDSPADGDGKRFYCAKCMHVVPCACIRPSFTSCAHDLCSSCVSQQLQGRRRQAGKLPRHQPADLLPKPKGNGDLPVDVDGELLDCAICMELVPGTLRFRVNSCAHAFCSSCVAQYIAAKLDDMVARIECPHPGCEDGAVEPESCHGIIPTDLLDKWGLLLCELAVGAKSNTGQEDVLPVPGMLGAPARRQRGGVPALPPAFLRPVRRAVARRLGVRRVPEARAGRARPGGPLAPASRRQGGLAAVPRVPDVRGEIGRVQLHQMQVWIQLLLPMRIRVVRAKPLLQQVQALISTVWLAMEGRFLPPTTT
The following text describes a protein:
Function:
Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.
Sequence:
MIILDKVSKHYQTRDKTRFAAVEPTSLEIRDGEIFGLMGYSGAGKSTLLRLINLLERPDSGKVNVCGQELTALDAAALRQARQNIGMVFQQFNLLSNRTVADNVAFPLEIAGWPSEKIKARVKECLEIVGLTERAGHYPAQLSGGQKQRVGIARALAPKPQVILADEPTSALDPATTRSVLECLEDINKRFNVTIVIVTHEMSVIRRLCDRAALLDKGKVVEIVEVRGNQIHAQSDIGRELIRED
The following text describes a protein:
Function:
May have a role in copper and iron homeostasis.
Miscellaneous:
MISCELLANEOUS: Present with 1510 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVKKIAILYTDEDNEWSKPWGNFVDMAIKLLEQTRKLECIAEDVEYEVFHVQKNVFPQLSDLQKDEYLGIYITGSKYDSFDNEIEWIMKLRSFLNEMLTSKTEYPPVAGICFGHQVIAAALGSSVGRNPKGFEGGVVSLKLNSVGQKLFGAQELNLSEVHSDCVFDVPEGYQNWASSEKCQNQGFYRQNRVLTFQGHPEFNSDVAQKGLLKSQDKLTLEEFNRYERQCQELDNNGIQAARNIWRLFLQKI
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MRKSNLQWSFSTSQFLSFKSAQDQAGTHKQYPPGFSQKKLGMDIKGGSQYPISSHHSWQPKEVVSVNQSPDILSRMFPAIGQANQFIPVIIGSAVGGANVSVTPANGPVVGSTDLKSCPSIATGSCQLTLFYNGSVCVYDNVSPEKAQAIMLLAGNDESNNSTASAAVPKIQPLVPPAKEAAVLNQSAGISIPVSSPMPVSSLPTSAPNCAVELNPIIKPVVAPSAHVKTPESPKSAAFVGAVSGAVKSIPSAVPQARKASLARFLEKRKERVTSASPYVVSKNASGCSIVEPGRSTSPAKLTSSTPLPATSVDILR
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MRPLLVFGLRGTLLERIHASRVPSGMPGGAITVGMSRVWLRPSAMETLLALQQHCTLAVWSSTTARNTTPLMEAVFSQHAQKVNFAFVWSREHTTADEFRRVSATSRDDQHATVKDLREVYRRFPEIATPQNTVLIDDTPSKGKLNASNFLWLETCEELKIENPNVMPALRRFVEEHLLAEREDVRRLLPARVPWGQQ
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MAEVLQEKDADEWAYRGEGAVNLVLAYCGSSPRFVGKVLRIQKVSNKVSKYENHHSALTKDERLLWGKFEGIVAARTREIAEQMYVQKVMCPLLGSEHVDAGIRILVSREFLKAVEHKVLLQRPAWRVDAAKVNPLCDSVLVIADHSIFPSVRGILKEDFCLSVEIKPKGGFLPTSDFIAEENAVKKRITRFKMHQALKLRDGVISQISKYDPLDLFSGSKDGVQNAFKSLFLTPQNNFRVFLNGSLIFGGMDGAADCVSYTVDQAFQDGIKRVIVAKDGMHSKYFLELVTETVIKSGLLNLLLEVQKLDAIDIEGAIHAYYDLVSLPCVICRQKGENKLSGRYSPIHLMSKHEKLKVVRDYLISATGKDLSMMISFRPRKSMDVESPHRSVLLKSINQTFDYKASFIDLDMKPLKKMEYYYELDQKIVSCYVQMVKDDEEIQNGVGIDGSLNSYIAKWK
The following text describes a protein:
Function:
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.
Miscellaneous:
MISCELLANEOUS: CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.
Sequence:
MDARRVPQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTRLQSVREGCRTRSQCRHSGPLRVAMKFPARSTRGATNKKAESRQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFRGRHPLPGSDSQSRRPRRRTFPGVASRRNPERRARPLTRSRSRILGSLDALPMEEEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEITEEELENVCSNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA
The following text describes a protein:
Function:
Probable methyltransferase.
Sequence:
MDINSNHIKKINDFKDKGNKEFNKEKNKDKLNKRAITYFQLGIKYFNDEKHKIEINDQINKLISILYSNLSLMYLKGDEIILSLEASNKSIEFNNQNSKAFYYQSICKSYLCDYKGSMESIDKAISISKQDEKVVQQRNRLIEITNNKVKEDVYFENVLKNQKLENVAYENSIEKGRYLISKRLIKRGEEILRIAPFSFSLNGKYVSKFCGVCYQKKSIDNLLKCKDCDDFAICKECKAPNEPLSKYHPNDLCVLYKLNNEYYKMNNFEIANEDNKERGLTDERRLYINTIYNIFKNKTNNKAVVEVDNAISSSVIDVLNLSKKLLNHTNESQRAYSDSTKMKTDILELIFKSFYGANTLKKDEISNIIRIVDCNSHGYSDVISQKKKASGLYPFSCYTNHSCIPNSDYFIDKHGVMVLYASSDIQESEAITISYIYFLNRVEKRRKDLLNGHNFFCTCDQCSFQSSLTEEVCDKCNEIIPSTIGNSNLVYKEPKSLKETGFNYICPKGHTKSSLVYDIDNDQLYPTIAENYSKCKDLRNFRKINIFKEMLENRDFVKKLTPREFEVTPLAKYIANPKKSNSMLFEELINLVRGSVECGLTKSIEESNYSTYLVYDYYDLYKSLLLESKPQILKLNSIRDIIIKLLTPMVYNQNKPRIDKKLNKHLSNKINLKKNK
The following text describes a protein:
Function:
Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
Subcellular Localization:
Mitochondrion.
Domain:
Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
Sequence:
IAALFITAKTWKQPTYGVGGTEAAPRAKPLGPARPEAPARNWQIISAGWVWDAGGAFGKGERAEEKRSFRARARELQLAALKKHRENEISHHAKETDCLKRETERHKRSIKKLKRRDDGGQVHTVLRGMATYYCPLLCGLCVDT
The following text describes a protein:
Function:
Required for radiation resistance and meiotic viability and acts in recombination and recombinational DNA repair pathways.
Subcellular Localization:
Nucleus.
Sequence:
MLSSQHRLVTQPAIRAYEAFSAPGFGFNSKLLDDAFGGSGLKRGYISEVCGAPGMGKTSLALQITANALLSGSRVIWVETCQPIPMERLRQLLDNHVPSSQDEEEKCDTDELLNLLDVVYAPNLVNILAFLRNFDQEKHLKEIGLLIIDNLSMPIQLAYPTSPEDYAYLRLRRNTSKKSSLSDSSQKENTLTLNKENEFSSKDDSNFAFHNSSTKTTINRRKKAIGTISSLLSKITSSCYVAIFVTTQMTSKVVSGIGAKLIPLLSTNWLDNLSYRLILYSRHSTEESKDGQSRPSHQLLRYAFMAKQPPAHSAESELAFQLTSTGIQDYQSIPTNSSQRRKRSILECES
The following text describes a protein:
Function:
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Subcellular Localization:
Cell membrane.
Sequence:
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV
The following text describes a protein:
Function:
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Sequence:
MKNNLFITFEGIDGSGKTTQALLLKEHFESKGYKVHLTREPGGTDVGNKIREILLNPAFSINYWTEAFLYLASRVENTINIIKKLKENYVVICERYADSTLAYQGYGRNLPLELLVEMNQIATFGLKPNLTILIDLDPELALRRKKSFDRIERENIEFYYKVRKGYLEIAKKEKERFIIIPGDLSKGEIFKRIVEEIERKNLGEVQK
The following text describes a protein:
Function:
Required for the lipid transport activity of the ALA/ALIS P4-ATPase complex.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=In a heterologous system, the final intracellular localization after exit from the endoplasmic reticulum is the prevacuolar compartment in the presence of ALA2 and the Golgi in the presence of ALA3.
Sequence:
MSSNTASSSAGAAGSGDSSAARKNSKRPKYSKFTQQELPACKPILTPGWVISTFLIVSVIFIPLGVISLFASQDVVEIVDRYDTECIPAPARTNKVAYIQGDGDKVCNRDLKVTKRMKQPIYVYYQLENFYQNHRRYVKSRSDSQLRSTKYENQISACKPEDDVGGQPIVPCGLIAWSLFNDTYALSRNNVSLAVNKKGIAWKSDKEHKFGNKVFPKNFQKGNITGGATLDPRIPLSEQEDLIVWMRTAALPTFRKLYGKIESDLEMGDTIHVKLNNNYNTYSFNGKKKLVLSTTSWLGGKNDFLGIAYLTVGGICFILALAFTIMYLVKPRRLGDPSYLSWNRNPGGR
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MPPKVTPKSNTMKYRQNNQKLKGQGRNIDYKKFPQHTNKSRLISNGDIRRLARRGGVKRISSDVYELSKLYMKLYISNILRDSMIYANYSGRATILADDICRAAKRAGQTAIGFTH
The following text describes a protein:
Function:
Transcriptional activator of alpha-amylase expression.
Subcellular Localization:
Nucleus.
Sequence:
MYRVKSESDCDMMLQDQMDSPVADDVSSGEGSPHRGSGPPLKKGPWTSAEDAILVDYVKKHGEGNWNAVQKNTGLFRCGKSCRLRWANHLRPNLKKGAFTPEEERLIIQLHAKMGNKWARMAANLPGRTDNEIKNYWNTRIKRCQRAGLPIYPASVCNQSSSEDQQVSGDFNCSENISNDLLSGNGLYLPDFTSDNFIANPDALSYAPHLSAVSIGNLLGQSFASKNCSFMDQVDHSGMLKQSGCVLPALSDTIDGVLSSVDQFSNGSEKLKQALGFDYLNEANASSKTIAPFGVALSGSHAFLNGNFSASRPINGPLKRELPSLQDTESDPNSWLKYTLAPAMQPTELVDPYLHSPIATPSVKSECASPRNSGLLEELLHEAQGRSGKNRQPSVRSSSSSANTPCETTTVVSPEFDLCPEYWDDHHSSFINECAPFSGYSFTESTPVSAASPDIFQLSKISPAQSPSMGSGEQAVEPRHESAGSPHPENLRPDALFSGNSADPSTFNNAIAILLGNDMNAECKPVLGGGITFGSSSWSNMPNACEISEFK
The following text describes a protein:
Function:
Sn-1-specific phospholipase A1 that catalyzes the initial step of oxylipins and jasmonate (JA) biosynthesis. Hydrolyzes polyunsaturated acyl groups preferentially from chloroplastic monogalactosyldiacylglycerol (MGDG). May function downstream of abscisic acid (ABA) and provide a link between ABA-mediated abiotic stress responses and oxylipin and JA signalings. In vitro, possesses broad substrate specificity. Can hydrolyze the galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), the sulfolipid sulfoquinovosyldiacylglycerol (SQDG), and the phoshpolipids phosphatidylcholine (PC), and phosphatidylglycerol (PG).
Miscellaneous:
MISCELLANEOUS: Plants overexpressing PLIP3 exhibit stunted growth and accumulate anthocyanin under normal growth conditions.
Subcellular Localization:
Plastid, chloroplast membrane; Peripheral membrane protein. Plastid, chloroplast stroma.
Sequence:
MDSLCLNSGLHGVIPAITAVGNGGCGGVVEVRATASAPSQKRGPFGFSFKYPLTPFWSRGGGGGIASRRRSGLCLDDAVLVDSGDSRKPIAEETAVEMDTERRNGSWVLKILDVQSTWKHEEEEDDDEVEDEDGDEDEEVELDDAVVSEDDGGCDVCSVLEDDGNEANKFQLDRESFSKLLRRVTLPESKLYAQLSYLGNLAYSISKIKPANLSKYYGLRFVTSSAEKTESALKAENGEVSGETKPIVEAEEEVEEEEKNKSRKISASAAYEIVASAASYLHSRTNNILPFNSSSKAENSDKHDVNLTNAESSSDVAYSVTSVVAAEEDVKQAVADDLKSTISSPCDWFICDDDQSHTRFVVIQGSESLASWQANLLFEPIEFEGLGAIVHRGIYEAAKGMYEQMLPEVKAHIKTHGTSAKFRFTGHSLGGSLSLLLNLMLLVRGEVPASSLLPVITYGAPFVLCGGDRLLKKLGLPKSHVQAIVMHRDIVPRAFSCNYPYHVAELLKAVNGNFRSHPCLNKQSMLYSPMGELLILQPDETFSPGHELLPSGNGLYLLTSDFESPDIEDSDEERLRAAQTVFLNTPHPLDILSDRSAYGSSGTIQRDHDMNSYLKAVRSVIRKEVNQIRRAKREHRRSLWWPILVARESGSSGIAVSNGQINGQDFSGMMQTGRKSLQRFSRLVASQHMPLIVVMLFPVKLLFLGAFNVFSFR