lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin (By similarity). Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression.
Subcellular Localization:
Nucleus. Chromosome. Note=In pachytene germline cells and oocytes, localizes to chromosomes.
Sequence:
MTKETDKKPKERPNQRKVAFRNEAINALVNTDEDQVTFSKAMEVAKLDCQKCLLHDMHSSKSSNCRDNPFCIHRLGLEKFEKLITQEQETKEEAKKDQKRRDLNDQPAGLINGGNFCYVNSFLQVWFNVPEFRQLIYDFRPSENFVPPEAPRMNVQATMLALQDIFYTLQTTPFNETDKTSNLGKLLRLNSEQQDSQEFGLKFFNALERCLPDHPNGKETLKRLKDLFTGETCTRIVCKCGQRSEREETAISLTLNIEGYCTLLDALDAYFGEEHLDDFKCSKCNKTGDVSKQSDYVKLPPVIVIQLNRYKYTSKGRQKLKTPMAYPREIPAKAFQRTNNSIPPPAEMYDLFAVTIHEGNNAECGHYYDLIKSPLNQKWYRYNDEAIEAIPKPPGTEKPTTAKTEKSRKKDKEKYPTDQKACYGLLYRRRDAFKPLPHPKLPPEELIIDSKTEIEELFEGLTKKKIEKSEKRLYDLERRINKVKISYGKLETHSDKYKEANEVVFLPTTLLQDVLAQEYEVAKGEKKKKKKEASENEEKKKNEEDEALSAAIAASEADQRDKASSEPSTSAAATEAGDDEELRAESETPNPENAESTQVAIMETDEIMDTTPTKDIDILAKAMEDNALPTVEVPQPELKKRTRQQNGEVKYVYSQRTPRKSHNGTNGTNSSPQKQPVSSRVAALLSSHEIPTCGHGKMSIDPILYGDVKAVSRAPAIALLREYDFRVKIVYDNGENVFPENEKERDVFIFTAEDICMECVREMREEGNFNNQLEDDEKLVRRILKEEKQRCSVKCPSERPDGYLYVAKFALSNFKKSAMSARENRLAQSHNKQGTLHFDSHPMFQQKSNSGYLTLSLKRTRGKPRKSLSEIPEKMQKLDEIGSKELPDEIIADEEEISENMGSDIPTKPVESINPDALVPFEKIEFNSELRCSHGGINFNQFRLSVSPEEWAHLKVYFDECYEVKCSDDVCDQCRQMEVDAQNGSENMRGLVREMRKRISDTLKTVESRAESKEDGADIKYGICSVFIDKLRKLTSRQSTSPPSICQECLLCPHQQPFKGFLNEDNHKDSHVVGLTEEEWNTFLTEIRKLEEAGDDQSIAVDPCPIPIENGQIVDMCEKCFEQHIKFTEEQKYMFENENIYVKLVNLNVEEDIAKANGKARRGRAKNLYAIKMSSTNKLMELKVQLYDKTHQLPNDQLLYRTAGGEQFDVSNNQKTLFDLRLSPNNNDNPLILIAQQFSPSASQADETGDRAPERGFVDTALAH
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDAPWGAGERWLHGAAVDRSGVSLGPPPTPQVNQGTLGPQVAPVAAGEVVKTAGGVCKFSGQRLSWWQAQESCEQQFGHLALQPPDGVLASRLRDPVWVGQREAPLRRPPQRRARTTAVLVFDERTADRAARLRSPLPELAALTACTHVQWDCASPDPAALFSVAAPALPNALQLRAFAEPGGVVRAALVVRGQHAPFLAAFRADGRWHHVCATWEQRGGRWALFSDGRRRAGARGLGAGHPVPSGGILVLGQDQDSLGGGFSVRHALSGNLTDFHLWARALSPAQLHRARACAPPSEGLLFRWDPGALDVTPSLLPTVWVRLLCPVPSEECPTWNPGPRSEGSELCLEPQPFLCCYRTEPYRRLQDAQSWPGQDVISRVNALANDIVLLPDPLSEVHGALSPAEASSFLGLLEHVLAMEMAPLGPAALLAVVRFLKRVVALGAGDPELLLTGPWEQLSQGVVSVASLVLEEQVADTWLSLREVIGGPMALVASVQRLAPLLSTSMTSERPRMRIQHRHAGLSGVTVIHSWFTSRVFQHTLEGPDLEPQAPASSEEANRVQRFLSTQVGSAIISSEVWDVTGEVNVAMTFHLQHRAQSPLFPPHPPSPYTGGAWATTGCSVAALYLDSTACFCNHSTSFAILLQIYEVQRGPEEESLLRTLSFVGCGVSFCALTTTFLLFLVAGVPKSERTTVHKNLTFSLASAEGFLMTSEWAKANEVACVAVTVAMHFLFLVAFSWMLVEGLLLWRKVVAVSMHPGPGMRLYHATGWGVPVGIVAVTLAMLPHDYVAPGHCWLNVHTNAIWAFVGPVLFVLTANTCILARVVMITVSSARRRARMLSPQPCLQQQIWTQIWATVKPVLVLLPVLGLTWLAGILVHLSPAWAYAAVGLNSIQGLYIFLVYAACNEEVRSALQRMAEKKVAEVLRALGVWGGAAKEHSLPFSVLPLFLPPKPSTPRHPLKAPA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASLLVRGGRPLLRKNVLQTLARCQVAALKTGAGGDKSTTAEVGEGEKKLHLPLGETIVRRGDRPGDIKDEDINWEWRGFSDDPVEDMKNHRAIFFWGISVCLVLVPLYLYYSPERHMRAWVKREGKMQYARRLREGVPLIDPNVVDPAKVILPPEEEVPDPLYNF
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MAQEPGAARGRAATAEGHHLQQPVAQHAKRRRPLVLEVSGLVKRFGGFTAVNNVSFRVDQGEILGLIGPNGSGKSTIFNMLSGTLAPTSGSILFAGHEIAGLAPHRIINRGIGRTFQIPRPFRRLTIFENVALAGFYGQGRHSRIKAEEAAERSLAMVGLPTDRHASVDGLGAAGLKKLELAKALATAPKLLLADESLGGLDETEMDQAADMLRNIRDELGITIIWVEHIMGVLMRVVDRVMVLDHGEKISEGLPSQVAGDPRVIEVYLGTDAETTQAAAAEARRRAGG
The following text describes a protein:
Function:
Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys); In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.
Subcellular Localization:
Mitochondrion.
Domain:
'KIIK' region and 'KMSKS' region are required for cysteine persulfide synthase activity.
Sequence:
MLRTTRGPGLGPPLLQAALGLGRAGWHWPAGRAASGGRGRAWLQPTGRETGVQVYNSLTGRKEPLIVAHAEAASWYSCGPTVYDHAHLGHACSYVRFDIIRRILTKVFGCSIVMVMGITDVDDKIIKRANEMNISPASLASLYEEDFKQDMAALKVLPPTVYLRVTENIPQIISFIEGIIARGNAYSTAKGNVYFDLKSRGDKYGKLVGVVPGPVGEPADSDKRHASDFALWKAAKPQEVFWASPWGPGRPGWHIECSAIASMVFGSQLDIHSGGIDLAFPHHENEIAQCEVFHQCEQWGNYFLHSGHLHAKGKEEKMSKSLKNYITIKDFLKTFSPDVFRFFCLRSSYRSAIDYSDSAMLQAQQLLLGLGSFLEDARAYMKGQLACGSVREAMLWERLSSTKRAVKAALADDFDTPRVVDAILGLAHHGNGQLRASLKEPEGPRSPAVFGAIISYFEQFFETVGISLANQQYVSGDGSEATLHGVVDELVRFRQKVRQFALAMPEATGDARRQQLLERQPLLEACDTLRRGLTAHGINIKDRSSTTSTWELLDQRTKDQKSAG
The following text describes a protein:
Function:
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit; Required for proper chromosome segregation during mitosis and error-free mitotic progression.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MDTDIIEIQKPKPVDPVETIVVPEITENEKEEIKKQQEEEEQDQQQEDEDNKIVPEIKKEENNTVNNNNNDDDNTKKVSNVKRGVCQIQGPTRGKPVSGRVWKTPSTKFNSAIKVNKGLQTTFEQKQKQREDLKRMKEKQNEIREKTKQDKIDMHNSIRENKKIKEENIKKSEQVQVINNTLKLKKLSKKDWKLYRKN
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSIYRSEHMKLCQIFFQSESAYQCVAELGELGMAQFIDLNEEQNSYQRKFVNEVRRCEEMDRKITFVEDEINKDLVPIPDYNDHIPAPQPKHMGEMEANLEKLEEELLQINKNTKTLKTNHIQLLEMKAVLEHVTSLMDHQSKREAAMSISEAARGEAGPFSVGLKQEFDKPVRDENELKFVTGVIKRAKSIAFERFLWRLSRAKVFAKFVQIQEKTDLFSHEYEDKCVFILFFSGEQLRSKVKKICDGFQAKCYTVPENPAERTKLLNNIKIQANDMKAVIEKTLDYRAKCIHTAAGNLRKWGIMLLKVKSIFHTLNMFSVDVTQKCLIAECWVPEADIAQVKNSLHMGTIHSGSSVPAILNEMETEKYPPTYFKLNKFTQGFQNIVDAYGIASYREVNPAPWTIISFPFLFAVMFGDAGHGIIMLLAAAGFVIFEKKLISMKIKDEIFNTFFGGRYVVLLMGMFAIYTGLIYNDFYSKSINMFGSSWTNPYPKSLLEQMDKQGAESKTELSLTFPPENAFDHGYGPYPFGVDPVWNLATNRLNFLNPMKMKTSILLGISQMAFGILLSLMNHIGNRSVVDIIFVFIPQCLFLGCIFVYLCLQVIMKWIFFYVKPAIIFGKFYPGSNCAPSLLIGLINMFMVKSRDPTFAFDINNGKGKYNATLDDGTKYTYTDYDQCYLQQWYPNQSLVEIILLLIAVVSVPVMLLVKPFYIRWRHSRGLPVDLGHGPEDEHGEFNFGDVMVHQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVLRMSLKMGGWGGSAAVTIIFYFIFSILSVCILILMEGLSAFLHAIRLHWVEFQSKFYGGTGIQFEPFSFTKIIRVYEGLDQ
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MGSNVAEFMAAEAEKDKLAIVNQKVESTRALSPAISSLISDLAVSALVNYLTNRVSQAGEVQIYRAGLSEIARCLTTIAKMPKFIKSEEDLKRGLLNCLTSNEGFASFVFPALFQKLDSESVRADVKIDVFDAMLECIRNYTNVSEFSTTIWDTLKWEVWNGENEDFINRSIENIAAVASQLGRQSSNIKDDNDKLAKYINHVTQECITIFTDDTKKRMILPCARILSKIASTSPHAFTLTFRNTLPTIFTLWHRLDTISDKARLVESLNIILETRSNISNTKDAKVVSGTTVMNEDFDGFRGSLVEVYFDEDFDGFRESLVELYFGAMSGSSSDLDLQIATTKGLTLLATIRNNSVNRPFLNSFEQGTIIEKLNETAFDMKIAEELRTLAVTSLSTLSVQYPDTFINITLPNFVGRLPDQLKPENGDGSDFSRIVGLLDSLVDIACKSVCQRELDAPDSDSKIHFKFRLFTALQSELIMRFTQHISKNAAQKSYQMAILAAIYRGLQVFDDALANDKTMGELFSNTGDTIDPYAFIAIALFKRVIGLFQHETGNLKGSWFVGISEVDKGEYFDDSVVALVGTIGTYILRSNTTSHENNFLLKANAENPTEPSRVWTLFNFGAHTRADLGVCQQDLRSGPSNKCSANILSAALIAGIRKEDVGRLGLTAHETAKSMLLNAISVENKCSRPARLGMLQMLQLLVNKFGADKKSFEDGKLLHDVMLQLVKEATSKPDPEAYQIYQALAYFAAATVAAYEPCSTALINAMMQGISDPKRGRKIAQSFAILLAPSNIMNDSNFCTLRPLRFGRLYSTTVSELITLWRSNDNSRIKENCLIALVGILRYMPAKILQDNAAQILPIALAGTDVPDKATKDASMNIMIVLMPENPSLIEEHLDSIINRMTDRTHNTYDSPSDATVEARSKALDVLGMLPTLVENGLLLKRKNAVLKELGIALDDCSREVRMRADRCKMIWFNL
The following text describes a protein:
Function:
Transferase involved in the biosynthesis of the lipopolysaccharide (LPS). In vitro, catalyzes the transfer of a polymerized O-antigen molecule from its polyprenyl diphosphate membrane anchor to a terminal sugar of the lipid A-core oligosaccharide, finalizing the biosynthesis of the lipopolysaccharide. The enzyme is functional and can be used to give diverse hybrid O-antigens in vitro, but K12 strains do not produce the O-antigen in vivo due to mutations in the rfb gene cluster (Probable). K12 strains are phenotypically rough, their lipopolysaccharide having a complete core structure, but no O-antigen (Probable). In highly mucoid K12 strains, WaaL can ligate colanic acid (CA or M-antigen) repeats to a significant proportion of lipopolysaccharide (LPS) core acceptor molecules, forming the LPS glycoform M(LPS). The attachment point was identified as O-7 of the L-glycero-D-manno-heptose of the outer LPS core, the same position used for O-antigen ligation. Cannot catalyze ATP hydrolysis in vitro.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLTSFKLHSLKPYTLKSSMILEIITYILCFFSMIIAFVDNTFSIKIYNITAIVCLLSLILRGRQENYNIKNLILPLSIFLIGLLDLIWYSAFKVDNSPFRATYHSYLNTAKIFIFGSFIVFLTLTSQLKSKKESVLYTLYSLSFLIAGYAMYINSIHENDRISFGVGTATGAAYSTMLIGIVSGVAILYTKKNHPFLFLLNSCAVLYVLALTQTRATLLLFPIICVAALIAYYNKSPKKFTSSIVLLIAILASIVIIFNKPIQNRYNEALNDLNSYTNANSVTSLGARLAMYEIGLNIFIKSPFSFRSAESRAESMNLLVAEHNRLRGALEFSNVHLHNEIIEAGSLKGLMGIFSTLFLYFSLFYIAYKKRALGLLILTLGIVGIGLSDVIIWARSIPIIIISAIVLLLVINNRNNTIN
The following text describes a protein:
Function:
Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAEKPYSGAADDHSRYGGVPTQMAYFGMDEHQTSKPSSFGLQENASSEAAKPWWNPHGWSLRAKLIAGALIVVALIAAIVGVVEGTRANRYPDYSRLDYRLLDTYSGPTFLDKFNYFSDKDPTNGFVQYVDRITAGKLNLTYATEASVILRVDTSEESPSNGRRSVRLESKKSYDTGLFIFDIVHTPYGCGTWPALWLSDTYNWPLNGEIDVVEANNGGTEGNAVTLHTTPGCDMKAKRKQTGHALYHQCDNSTHGNAGCGVQAPPASYGPEFNENGGGVYALELRTSGIRAWFFPRGSIPNDILDNIPDPTTWGTALADFPNTNCDIASHFSNQSIIANIDLCGQLGAQPQFYTHLYNCPGTCSSFVARNPANLTEAYWEFKSFKVYQAQ
The following text describes a protein:
Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MLDAILGSKGRQKEIQKLRGFSTAVPAATSSRPATQAATGRGPPPSDNEMIAMLSGRLRKAEKQLSLATDAINEKARVAHHHLASLPAPQANHHHKRRWSGTDVLIRRLTKQVKLLEGVQQNRESDLSALSTLQDEYRKLQNQVHSMESFLADYGMVWVGDEEDDDKMTSESAVADAQPTSAITSAALVEAATASVSQHNAATATDPEPASKGADGDDHARGSTPPFHVDYDKIIANVHELNVLAGEGVARVVAAPGGGRLEVPEAVPMHLYRNGILLFNGPFRPFSDATTQMCVRDLMDGYFPWELRQRFPDGIPFAIHDHRGQDYQRTTIKAFPGSGYALGGQATTSVLLQEDGPASTTGPEAAQIATPGLQAVSGPSKTQAFLNHLPPTVIRNGCIMDIRQGLAGHLTVQTREQHRVQLVATPVTQHLAAQAAVPTASPQRPTTPRDIATLQVKSEDGKVTLIVKLRFNDSVADVRRCIDQHRGTSVDATYRIYTTYPRKLLDDSSATLLDLDLVPNATLRLVANKSKKV
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
Subcellular Localization:
Peroxisome.
Sequence:
MSPPGLPQEPDRNSLLDDAKARLRKYDIGGKYSHLPYNKYSILLPLVVKEGKLHLLFTVRSEKLRRAPGEVCFPGGKRDPTDMDDAATALREAQEEVGLRPHQVEVVCCLVPCLIDTDALITPFVGLIDHNFQAQPNPAEVKDVFLVPLAYFLHPQVHDQHYVTRLGHRFINHIFEYTNPEDGVTYQIKGMTANLAVLVAFIILEKKPTFEVQFNLSDVLSSSEELFLKVHKKATSKL
The following text describes a protein:
Function:
Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MQRVLNKIISKDTINTMGKVAISKKVEKLRTFMKDQSLSAYIVPSEDAHQSEYICVKDKRREYISGFSGSAGCVVITLDNQLLWTDGRYWLQAEKELESNWKIMKDRVVGEPTIQDWLLSNLNKENKVGIDSRLISKGYYDSMKLVLKEKSIDIKFDEDGENLIDKVRESFKDEEEIPEYPKNSIFFLEDKFTGKQSNEKLKEIREEMKKQSADLMVVSALDEIAWLLNLRGSDISFNPVFLSYVVVEHEKVTLFVDESKLNDKTKSQLPSGIAISPYSSVFEYLRNSDKQGKKIWIDPRSSVALYNCVSISNLLEKINPILLSKAIKNETEIQGMKNAHIRDAVALIQFLAWMEEEIVEKSDETSHTEYSVCEKLEGFRRQQTDFVSLSFDTISSINANGAIIHYKPDETTSATIVKGMYLVDSGAQYLDGTTDVTRTLHYGKPTQHEIDCYTRVLRGHVGLSLLKFPNRVNGRDIDCVARTHLWSVGLDYAHGTGHGVGSFLNVHEGPQGISYRAIANPTNLQAGMTLTNEPGYYESGNFGIRIENVMIVAPVTTQFNNGKFIGFDNITLVPYERKLINLEMLTKDEINFINDYYKEIGEKILPLIEKTNNQKSINWLKNQIKPL
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Binds chromatin (e.g. nucleosomes and histones) and has enzymatic histone deubiquitinase activity, specific for the H2B histone. Can both repress (e.g. OSR2) and promote (e.g. AN3) the expression of target genes by associating with chromatin, deubiquitinating H2B and regulating its euchromatic histone marks (e.g. H3ac and H3K4me). In association with LDL1/KDM1C, involved in transcriptional gene repression via histone deubiquitination and demethylation. Promotes the concerted epigenetic regulation and repression (e.g. the removal of euchromatic histone acetylation, ubiquitination, and methylation marks) of a set of genes (e.g. GA20OX, WUS, OSR2, ARL and ABI5) that collectively limit plant growth thus stimulating plant growth and increasing cell size.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTRILVQRGSSGSSSNSSRPSSSSSSSSGSETQINNNIPVPPVTIDEEITDEKQEEVTVVEKAECSDAKDVAVDSDEPADREDDEGLVVAENVHVQSEGIDCDSPVSGGSNSDSPPVPAPPPKPSSTVNPGSNRSVLGSFGALRIGPTRRAAGPRSLVSSRSSPTGSHPSSPRSHSENEGYNSSDEHMPCYVPSHPGSGLEREHQFEAEIRYSKGFEIRRMLEDGNCLFRAVADQVYGDSEAYDLARQMCMDYMEQERDHFSQFITEGFTSYLKRKRRDKVYGNNVEIQALAEMYNRPIHIYSYSTEPINIFQGNYSTDTPPIRLSYHHGNHYNSLVDPHRLTVGAGLGFSSLSGRHVDKEQVKAAIKAQQEHQIDNALLAEGRFYSDLELTEKEIERSVMEASRAEYLMEWSKPRIGPKESSTSNAETSSSGARPSGSDSKPAEAVKEKTVLSSSIEMVLSMGFSYAQAMEAYSIFGDDVDSMVCYVLETSCGGNNRRKGKATE
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MNGGEEFSNDGSKLGEKKRRLNMEQLKTLEKNFERGSKLERARSKTKQLERDYDELKRQVESLKHENDTLQTQNQKLEAQVKALKSREPIEPINLNKETEGSCSNKSENISGDIRPA
The following text describes a protein:
Function:
[Isoform 3]: Does not affect cell growth.
Subcellular Localization:
Note=Contrary to isoforms 1 and 2, isoform 3 does not localize to the mitochondria.
Domain:
Contrary to isoforms 1 and 2, isoforms 3 and 4 do not contain any BH3 motif.
Sequence:
MKFGMGSAQACPCQVPRAASTTWVPCQICGPRERHGPRTPGGQLPGARRGPGPRRPAPLPARPPGALGSVLRPLRARPGCRPRRPHPAARCLPLRPHRPTRRHRRPGGFPLAWGSPQPAPRPAPGRSSALALAGGAAPGVARAQRPGGSGGRSHPGGPGSPRGGGTVGPGDRGPAAADGGRPQRTVRAAETRGAAAAPPLTLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDSGGRPLPPPDTLASAGDFLCTM
The following text describes a protein:
Function:
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network (By similarity). Inhibits host IKBKE and IRF3, thereby impairing type I IFN signaling.
Subcellular Localization:
Host nucleus inner membrane; Single-pass membrane protein. Host cytoplasm, host perinuclear region. Note=Also localizes at the transient membrane of perinuclear virions.
Sequence:
MASPEERLLDELNNVIVSFLCDSGSLEVERCSGAHVFSRGSSQPLCTVKLRHGQIYHLEFVYKFLAFKLKNCNYPSSPVFVISNNGLATTLRCFLHEPSGLRSGQSGPCLGLSTDVDLPKNSIIMLGQDDFIKFKSPLVFPAELDLLKSMVVCRAYITEHRTTMQFLVFQAANAQKASRVMDMISDMSQQLSRSGQVEDTGARVTGGGGPRPGVTHSGCLGDSHVRGRGGWDLDNFSEAETEDEASYAPWRDKDSWSESEAAPWKKELVRHPIRRHRTRETRRMRGSHSRVEHVPPETRETVVGGAWRYSWRATPYLARVLAVTAVALLLMFLRWT
The following text describes a protein:
Function:
Transcription factor involved in the symbiotic nodule signaling pathway in response to rhizobial stimulation. Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation, and nodule development. May coordinate these processes. Functions downstream of the CCAMK-CYCLOPS complex. Probably not involved in arbuscular mycorrhizal (AM) symbiosis.
Subcellular Localization:
Nucleus.
Sequence:
MEIQFQQPNLQQHQKAGTKGGKFKGRNRNSNTNKFVGVRQRPSGRWVAEIKDTTQKIRMWLGTFETAEEAARAYDEAACLLRGSNTRTNFITHVSLDSPLASRIRNLLNNKKGNKKQEGVVDVGVDVDVPAPSASTTSTSSNTSNSDKNDHNSLSSGKVQNTMLFDDAYKPDLSNCKEDFQSCPPQSNFSWGFGPVFDRFPIAQILDMPKTDGMIDAASLELSEFERMKVERQISASLYAINGVHEYMETVQDSNETLWDLPPLCSLFC
The following text describes a protein:
Function:
Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTVSTTFFTLEEVAANHSSKSLWVIRNNKVYDITHFIDDHPGGGEILLQFGGKDITQAMHDPNEHMHSESAYDVLEDFYIGEVVQSQRTKKSLVNDTTASNKSVDPFIDIHKPMVYQVWTSNWSKSYYLKMVHIPRHAKHTAPFFGSKYLEVFTTTPWWLIPIFWVPIASYCMIDALRTLSPKVGLACFIMGLLNWTFIEYGLHRFLFHVDEYLPDNRVGITMHFLMHGVHHFLPMDRWRLVMPPALGFALAYPIWWLYVLSFPGGFGQGMMSGSLIGFVIYDLIHYYLHHGGQFISHLKEMKSYHMDHHYKDPNLGFGITSKLWDYLFSTTL
The following text describes a protein:
Function:
Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLTDKTEGEGESQRTQSHISQWTADCREQLDGSCSFSRGRAPPQQNGSKDNSLDVLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQSLPHIDREGCGKGKMEDGNGISLNDIEKVLPTWQGYHPMPHEVEIAHTKKLFRRRRNDRRRQQRPPGGNKPQQHGDHQPGSAKHNRDHQKSYQGGSGPHPSGRPTHHGYSQNRRWHHGNMKHPPGDKGEAGSHRNAKETVTVENPKLEDGPGDTGHSGLEPPCSPDTLTPTASERPTPQLPGGSEAETKQKDTALPERLGERPKITLLQSSKDRLRRRLKEKDEVAVEASNPQPNKMDRLTEILNSMRNNSSDVDAKLTSFMEEAQNSTNSEEMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMVEGTKFRSLLLNMLQKDFTVREELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLREDTLLCHASRKRKSQEKPKAKSACLLPILDLTKPRSLSMATCPHNTECCKHLFK
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MPPTAKRPRQKSPQHEDPGARPRESPDPEASASHLVSFLSGYADHQSDEEENEHDLDDDDADRYEPSDQEEDAEDGVNEEEEETRVTPRKMGLLPASMTSTPRSKRGTPKKRKPGSTTPTPRRTPVKTPKRSFVLAPGDGEQEDMGFIRASKADGYFTLMAQSSKTSGNSYSLLADPLSKQAYERYIAESSEVRATLIPPETFMGKFRQWEKELEAGFNLLFYGFGSKRPALNLFAQNRLAKKGHVVVVNGFFPGLGIRDVLSEVEDRLEVPQNVSVPAYCSTPLERAAHRIYAYLLPPAAIQSHSRKHWPTASAPLYLVIHNIDAQSLRTPRSIATLSLLASSPRIHIIASFDHVHTPIIFSTSLSNSPPHSYPDGGWRGTPQKDRGFNWIHHSLTTYAPYDLELSYLRLSAQSLTPSGSGTGGISEEGALQILKSVPVKAARLLKLILTQQLSRLPSHPKWHVAYPAPSSGSGIAPPFAVDGYLLNKTAKDKFIATEDERFEAFIGEYKDHGLVAEASVASDVDENHDGAVTEGRKEGRWFWVPLGKAAVERILQSMEDIES
The following text describes a protein:
Function:
Iron-dependent dioxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate (4-HPPA) to 4-hydroxymandelate (4-HMA) in the mitochondria, one of the steps in the biosynthesis of coenzyme Q10 from tyrosine.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAPALRLCHIAFHVPAGQPLARNLQRLFGFQPLASREVDGWRQLALRSGDAVFLVNEGAGSGEPLYGLDPRHAVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAVVSSPAGILSLTLLERAGYRGPFLPGFRPVSSAPGPGWVSRVDHLTLACTPGSSPTLLRWFHDCLGFCHLPLSPGEDPELGLEMTAGFGLGGLRLTALQAQPGSIVPTLVLAESLPGATTRQDQVEQFLARHKGPGLQHVGLYTPNIVEATEGVATAGGQFLAPPGAYYQQPGKERQIRAAGHEPHLLARQGILLDGDKGKFLLQVFTKSLFTEDTFFLELIQRQGATGFGQGNIRALWQSVQEQSARSQEA
The following text describes a protein:
Function:
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Sequence:
MKKVAGIVKLQLPAGKATPAPPVGPALGQYGANIMEFTKAFNAQTADKGDAIIPVEITIYADRSFTFITKTPPMSYLIRKAAGIGKGSSTPNKAKVGKLNWDQVLEIAKTKMPDLNAGSVEAAANTVAGTARSMGVTVEGGPNA
The following text describes a protein:
Function:
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. Possesses high activity with PG species carrying dioleoyl groups and low activity with species carrying one or two palmitoyl groups. Cannot catalyze the phosphatidyl group transfer from one PG molecule to another to form CL. In mitochondrial fission, CL stabilizes the protein complex of the major mitochondrial fission factors, DRP3A and DRP3B.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAIYRSLRKLVEINHRKTRPFFTAATASGGTVSLTPPQFSPLFPHFSHRLSPLSKWFVPLNGPLFLSSPPWKLLQSATPLHWRGNGSVLKKVEALNLRLDRIRSRTRFPRQLGLQSVVPNILTVDRNDSKEEDGGKLVKSFVNVPNMISMARLVSGPVLWWMISNEMYSSAFLGLAVSGASDWLDGYVARRMKINSVVGSYLDPLADKVLIGCVAVAMVQKDLLHPGLVGIVLLRDVALVGGAVYLRALNLDWKWKTWSDFFNLDGSSPQKVEPLFISKVNTVFQLTLVAGAILQPEFGNPDTQTWITYLSWLVASTTMASTAAYGVQYWKKRPISMIKRS
The following text describes a protein:
Function:
Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance. Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1. Required for fully efficient Hsp70-mediated folding of proteins.
Miscellaneous:
MISCELLANEOUS: Present with 13100 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKLLQWSIANSQGDKEAMARAGQPDPKLLQQLFGGGGPDDPTLMKESMAVIMNPEVDLETKLVAFDNFEMLIENLDNANNIENLKLWEPLLDVLVQTKDEELRAAALSIIGTAVQNNLDSQNNFMKYDNGLRSLIEIASDKTKPLDVRTKAFYALSNLIRNHKDISEKFFKLNGLDCIAPVLSDNTAKPKLKMRAIALLTAYLSSVKIDENIISVLRKDGVIESTIECLSDESNLNIIDRVLSFLSHLISSGIKFNEQELHKLNEGYKHIEPLKDRLNEDDYLAVKYVL