lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi apparatus lumen (By similarity). Involved calcium homeostasis and both conidiation and polarized growth. Its activity is coupled to the unfolded protein response (UPR) and Ca(2+) import into the Golgi apparatus is important for virulence, cell wall biosynthesis, and resistance to antifungal compounds that inhibit Ca2+ signaling.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSRSATPALPLHNAQASRPSSRAPVTGVRSPSTSTSTYSLLGPEETAERLQTSLLHGLTPAEAEIRLLRDGPNELPHEEPEPLWLRFLKQFKETLILLLLASAAISFFMGNYDDAVSITLAVTIVVTVGFVQEYRSEKSLEALNRLVPHHAHLIRDVPPSSAPLMNNSTTAALGPDIELEDLASKSPSSASAAIKASSTVLASELVAGDLVLFTTGDRIPADIRITAATDLTIDESNLTGENEPVAKYPEALRSTKAAVSHSPKIVSPPRSPFYDAPASGAVGADIRLNEQHNIAFMGTLVRSGYGQGIVIGTGAKTEFGSISVSLQEIESPRTPLQLSMDRLGQELSYISFGVIALIVVIGLVQGRKLLEMFTIGVSLAVAAIPEGLPIIVTVTLALGVLRMAKRGAIMRRLPSVETLGSVNVVCSDKTGTLTLNHMAVTKMWHFDCPEPFEVHNDISSLTSGPAARTVLRIGNIANNARLSRVSANSPASASSAAVLSSTVDRASGAVKSRWVGQPTDVAILDLLDTFGEDDLRDRISRRVAETPFSSERKWMGVIIGSAQNDAPSFTGANNVAYIKGALEQVLTRCDTYLTKDGREVILDEPRRHTVRQAAEHMASEGLRVLAFASGAVRDTAGGGRVFGSRTSTPLSITSQGDEDDRYTGLVFAGLVGMNDPPRKDVHKSIRRLMAGGVRVIMITGDAESTAVAIAKKLGMPVRDSPGSRPVLTGQDLDRMSTADLAQAISTTSIFARTSPEHKMKIVRALQSRGDVVAMTGDGVNDAPALKKADIGIAMGKLGTDVAKEAADMILTDDDFSTILRAIEQGKGIFYNIQNFITFQLSTSVAALSLVLLSTLLGFKNPLNAMQILWINILMDGPPAQSLGVEPVDPTIMNRPPRSRTARVLTRPLIQRVLTSAFMIMLGTLAIYVYEMGDADDLSTPGKRSRVVTAHDTTMTFTCFVLFDMFNALTCRSESKSVLRGELPLFGNKMFNYAVLGSLFGQACVIYVPFFQRIFQTEPLNAAHLLKLLCVSSTVFWVDEGRKYLNAVKRRRAVGVGYSVNV
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTKKKINKNESVNQSYTSNSNSNGKINIADYLFGIFLFIVMLFHLVICPFTKVEESFNLQAIHDIIHHGISNDREQLASYDHLEFPGVIPRTFIGSLLVSAVTVPIKKFFEAVISDPEHQYSKLLDLFICRGVLGLFTSIALFKFQRAISWKFGRVTGYWFSLITLTQFHLMFYMTRTLPNTFAMVPVLFALANWLRDKTGPMVVWLTIAIFIFRSEVLVLAGPIVLCCLVVQRNLSFGKFILLGIVTAVLSVATSVGIDSYFWRRWLYPEGEVFLFNTVENKSSEWGTSPFYWYFLNALPKTLALSTLLFFAGIFYEGKRVAVYIVPVLVFVGLYSILPHKELRFIFYSIPVINMVSSLGAYRLTTTVKLNRFFKLIVSLGIVGIIVGNFLLSMGFLYVSSFNYPGGYSFISLHSHLGITDSSGLFLLKQNNDSNHQKYKIHIDNLAAITGVSRFGEVATTNQFEYSKKERDVILTDYTHIIAPNTTSTNKGFIEIDSIDSYSSIKFSKEYPYIQIINLPSLYIMENDKYNRK
The following text describes a protein:
Function:
Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion outer membrane. Extracellular vesicle membrane. Note=Forms virion-like extracellular vesicles that are released from cells.
Domain:
The protein is evolutionarily related to retrotransposon Gag proteins: it contains the capsid (CA)subdomain of gag; The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction; The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins MAP1LC3A, MAP1LC3B and MAP1LC3C.
Sequence:
MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMTVGELSRALGHENGSLDPEQGMIPEMWAPMLAQALEALQPALQCLKYKKLRVFSGRESPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAEEEEALLQAILEGNFT
The following text describes a protein:
Function:
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrium between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRPNKAPPAASKDGPRINDDIRNAQIQLIDQTGDNKGTVETVVAIKMAQEAGMDLVEISPNTSPPVCKIMDYGKYKYSAQKKAAEARKRQKTVEIKEIKLRPMIDDHDYDVKMRAMQRFFEEGDKVKITLRYRGREMAHQEIGTKLLDKIKTDVAELAKVEQDARFEGRQVVMVLAPR
The following text describes a protein:
Function:
Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.
Sequence:
MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFRPECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERGNASSSQKEKVLPEAGAGEDSPGRNMDTALEELQLPPNAEGHVKQVSPRRPQATEAVGRPTGPAGLRRTPNKQPSDHSYALLDLDSLKKKLFLTLKENEKLRKRLQAQRLVMRRMSSRLRACKGHQGLQARLGPEQQS
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MELSSTFAGACPVIMGEAFHIDDLLDFSNEDIAGPIGEGLLSSLDSTITDVETISTTGSPSLAGTKHILDGDDVVAGDLCVPCDDLAELEWLSKFVEDSFSMGEATRPVTSSGGLTVSTDVQIESYTNKDRDRFQSASPVSVLESSASSERASNLYRELSVPGRARSKRARTGGRGWGTTARILSSSSNSGSGSGSGSGSGNDTESLSSDSNAMTGGGNSSSQTLSVDSQATPSAAMIAPKAVSSSAKKPWKASKSGKKGQDASQPWRCMHCSTQRTPQWRAGPMGPKTLCNACGVRYKSGRLLPEYRPAGSPGYIGHKHSNSHKKILEMRRQREQQQQSQPSSMLSSSSCQVSPNHLLELEDPDICNSQS
The following text describes a protein:
Function:
Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVETAVILAGGEGNRLKPLTEEVPKALLKVAGRELLYRTIKQLQDVGVKNFVIVVNKKFEGKVKAFLKEHNFEAEVIPNEHPEKENGYSLYLAKGRIKGEFAVVMSDHIYEKAFLEKAVEGKGLIVDRLGLYINKNEATKVKCEEGRIKYIGKNLEKYDGFDTGFFVLDESIFEVAEEALKEQKKLTMSELAKRAQIPCTEVSGYFWMDVDTPEDVEKAKKYLVKTAIKGVGDGFISRNLNRKVSTRISPYLVDKFTPNQLTVLTFLLGMFSALVAYFSPALGGILLQINSMLDGLDGEVARAQMRTTKFGAWLDSVLDRYVDFAFLSALAMHLKPSWDFMPWVFAALFGSVMVSYSTERYKGAYCEDAYAVIKELRYLLGKRDERIFMIMIFTILGWIKALFVVLAIITNLRVILTIYLVWKKKGNV
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSKARQPPLVTGISPKEGTSWTKVTIRGENLGTGPSDLIGLTICGHNCLLTAEWISASKIVCRVGQDKNDKGDIIVTTKSGGKGTSTVFFKLLKPDKIGILDQSAVWVEEMNYYDTRTDRNKGISPLSQRTANPLGIEIDKQKIQSQAIESLFPGMSGDFNCENFSATSYLITNHSTASFEQLKTAANNLRKQASKKNEGNVAYVKGGLSTFFEAQDALAAIHQKLEADGTEKVEGSMTQVLEKVLKSASTTADTLFQEVLGRKDKADSTRNALNVLQRFKFLFNLPLNIEKNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKVYAEVETRIESLRNLLLDKLLETPSTLHDQKRYIRYLSDLHAPGDPAWQCIGAQHKWIVQLMHSCKEGYVKELKGTPVLQSPLLDIDSDGRPSPLGRLSQNTSLQRGSSFQSGRNDTWRYKTPHQVSFVDKLTKVVVGQLPNFWKLWISYVNGSLFSETAEKSGQMEKSKKNARQRQNDFKKMIQDVMQTLVKLIRGALLPFSLEEEELKHFGGWEVKSELFGPWLMHVVQTVRLSHESLTALEIPNDMLQTIQDLILDLRVRCVMVTLQHATEEVKRLADKEDWIVDNEGLTSLPSQFEQCIIQALQSLKGVIECKPGETSIFQQQRIQDDLCYLCINLIQVFITSLEYLSTKPAGGVDIMHISADVSSPDLFGSIHEDTTVSPEKRLLIVLSNCHFIERHTLLNIAEHFEKYGFQAIEKITRASTDSLKELDFRLFECYIENKADPIVGSLEPGIYAGYFDWKDCPTPTGVRNYLKEALVNIIAVHAEVFAVSKELVPRVMARIVEAVGDELSRLMQCVSSFSRNGALQARLELYALRDAIAIYLTNDSKSSFKHAVEALPQLPSGSDKKLLEELLNEFKSSMHLQLTCFQSSSSVSLKT
The following text describes a protein:
Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MTASAGVESMSPPPSAEERINHLTHQQQQYVTSNHSTSQLAQRKPLLSQQQQQQQQPSAASGFTQHPSLGPATMKPPPRPTATTAGARGPPKPPSDRSKGAGGSTGGTTLPSRVSQIYYKHGLFLSSYPTTATSFALAIIIFCCYPLLNIPLPGTIPTKVIFPYTESISENLHLSNANLTSEFYNPFSFSGGNMFNIYNISVETPFPWARIDPLLYVQQIIMRTSVVPWEEDLLLTDAFRAPLYEVFKLLEIIRNHEDQSKTMLSHLCLHVENVKRSSQQTLFPEYNCLLLSPANLWQQNMQNFNKDSNLLNTVYVNHNLQKSKVSTAEMLFGIPLRDTGVKRYPMRVRPRIIQYAVTLILRENNPAFIESLKQKLTRAYPLHQKEPSTDASGGVPAQPEAPSAPKQQQSIMYIFYPGEFNWKEVLPQCIAFCVLFIYVYFSVRKIEAIRSRIMLASCAVLTVLGSLLMSLGLCFFFGLTISFQSKGVYPYLVILVGLENVLVITKSVLTTDNNLDVKIRVAQGLSREGWSITKNLLTEITILTGGLATFVPVIQEFCIFAMVGLVSDFLLQMLFFATVLALDIKRVEYSAEVRRLPKMLYFNNELRRGTGTAAGQTNGPAREVRNGGGSINRSRSHPKLTGLEQAASHPKTGPGSGKDVKIPKRLRIVNFWARTRFFQRGFMIWMVLWISNIIYNAGLIEELFVIDKNLTGHERLPLDAGAPRFEGGGLAMHDLGDPSTEATLEMDRLNYHKNLPDAGMLRGGGGGGGVASDKAGTVEHRALNVSEQLQRLKHPDYETVYQLSNFHWSSILKQYNVSLSGRYVTVLPAIKLSHAVSPATAIQLRNADEKAPHHFQWKALAVALDPLDFSDADTGDGSHVPIGNAPFYPKTPMEILLTCMLLVVSTFVVTYTMIVLYRCVCTRNYAEWRASWQESDSETEPKPEQCLLEGVPVQVDGHVHRIECLVTDGNMVASSCLQGQVKVWDVSNGELLAEIDRLHYFELQQHRGSSASPQSLPSPPTAGVLLRNDLGEPITGLQEAFPVAGGSSSSPVSCSPPGTAVAASFKLRKKLHFNFSSLDGGAAASGQAASDSKLFDFQAQYERFFTPCSPPVANGAVNGGSGCDLRNRFASNGAPVASWVESNASTEEQPSNSHWMARPTTLSNECPQPPGSPKQQQHHVSPIWCLDFLDNLIVIGCADGRLEFWEGSSGSFKCIHDAEHSHNNGVTNIKLTGDRVIAARLSGRIDFFRLETYNQGRQIDWGFTSAYRRTHMRTGSAGSLGSLQAAMAASSGPGSHSASEELRCLLEFQQQGHQQPVTCLEVAGNTVMTGSQDHTLKVYRADSHVMLYTLHGHCGPITCLFIDQWQSGMAGSGSQDGLLCVWDLTTGACMYKIQAHDDSIVALVGSPSYVISLGLDERIRVWDRFQGHPLNTITVSHAYSALVMLTPSLLVTGKPGALVVWDARSGEVAREVKLDCSNMQLCPKIMLPACGSVICDYGNQMRIVRFPLVAADKCD
The following text describes a protein:
Function:
Part of the ATP-binding cassette (ABC) transport system YfeABC involved in iron import. Binds iron with high affinity and specificity and delivers it to the membrane permease for translocation into the cytoplasm. Also binds Mn(2+) and Zn(2+).
Subcellular Localization:
Periplasm.
Domain:
There is a second metal binding site (site 2) involving Glu-162 and His-163 which can bind Mn(2+) or Zn(2+). It is unclear what its physiological function is but may participate in protein-protein interactions with other metal- binding proteins.
Sequence:
MIERLNSPFLRAAALFTIVAFSSLISTAALAENNPSDTAKKFKVVTTFTIIQDIAQNIAGDVAVVESITKPGAEIHDYQPTPRDIVKAQSADLILWNGMNLERWFEKFFESIKDVPSAVVTAGITPLPIREGPYSGIANPHAWMSPSNALIYIENIRKALVEHDPAHAETYNRNAQAYAEKIKALDAPLRERLSRIPAEQRWLVTSEGAFSYLAKDYGFKEVYLWPINAEQQGIPQQVRHVIDIIRENKIPVVFSESTISDKPAKQVSKETGAQYGGVLYVDSLSGEKGPVPTYISLINMTVDTIAKGFGQ
The following text describes a protein:
Function:
Involved in the control of plant growth development. Acts as negative regulator of seed germination, cell division in meristematic regions, plant growth and overall biomass accumulation. May function by regulating ribosome activities and biogenesis in plant cells.
Sequence:
MEEVSSEMEVEVQNRQLSDSSPAQNVKKFGLKNSIQTNFGSDYVFQIVPKIDWTAIAVSLSTNTVKLYSPVTGQYYGECKGHSDTVNQIAFSSDSAASPHVLHSCSSDGTIRSWDTRSFQQVSRIDTGNDQEIFSFSYGGAADNLLAGGCKEQVLLWDWRNSKQVACLEESHMDDVTQVHFVPNKPNKLLSASVDGLICLFNTEGDINDDDHLESVINVGTSIGKIGFLGDGYKKLWCLTHIETLSIWNWEDGSCEVNLEKARELASDSWTQDNVDYFVDCHCPGGEDLWVIGGTCAGTVGYFPVNYKQPGSIGTAEAILGGGHIDVVRSVLQMPGEYGGAAGLFGWTGGEDGRLCCWKSDEDATEINRSWTSSELVVKPPRNRKKNRHSPY
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MATAIAPITGMLRRGLVLDLSTAFGFGTTFGYLWWYGYHLPRVRARDEYYNRLEQERAAGQA
The following text describes a protein:
Function:
Involved in the regulation of pollen surface morphology, probably by modulating the secretion of proteins and/or lipids during pollen development.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MGHRVLVYVGALFLILFTIFPSSSALISSPDANPPYPKAISDLKESIVKGLGFQSEEVKVSGFDIRDALVGHSVSYEFDLEIDNKVLPFKLLEDVNRWEYVDLPIFQVEQPSENGLVPMRNKKTSSDDVLPVLAPFQLSGPMELWIQDANNMRLSLPYDVDAGVLKKVILADGAVVTVKGARSVSLRHPIDLPLPLNQSSNEFASGLLSLAEQLRRASTDQESPVLSLRIVGPTSLASTSQSPDNKLKLKRLAPGLVELSSMSKDKRSLSTIGANAMTTVLTPREFTTMWPITSINGSNANLLGFEKLLTSVLGPKAQEKGSFKVLKAKVAAQTFMKIGFGIEKKLKEADVEGLSFPEWRTKPETMRMHFEVLAKVDGENVIPENVMRVDPIPLEDTIAQNVITGNVTMSKLPIIESPPSPFTL
The following text describes a protein:
Function:
Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth.
Subcellular Localization:
Nucleus.
Sequence:
MSDLKTTKDTLVSTLFELSKAAQDAANAAIEFYKVASGGSDHVSAEQLKAVSEALNTVATLSSGNGAKIEATESKKKRKQEKDPNAPKKPLTMFFQFSYDLRKKIGIERKKKDLPSLSAIDMNSMIKDRWDSISEAEKAGYKKRYDDAMIIYNIEKKKYEESLKDGSAYYPPPSVQTPIVGHGIEQDFDDDATDIVSSPEEPKKKKKKTEKKEKKKKSGHGSP
The following text describes a protein:
Function:
Histone methyltransferase that converts monomethylated 'Lys-9' of histone H3 (H3K9me1) to dimethylated 'Lys-9' (H3K9me2) in the absence of bound ubiquitin, and to trimethylated 'Lys-9' (H3K9me3) in the presence of bound ubiquitin. Acts in a locus-specific manner and contributes to the transcriptional silencing of pseudogenes and transposons. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with euchromatic regions.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MISLSGLTSSVESDLDMQQAMLTNKDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGNWSYIKLDNYTALVDAIYSVEDENKQSEGSSNGNRGKNLKVIDSPATLKKTYETRSASSGSSIQVVQKQPQLSNGDRKRKYKSRIADITKGSESVKIPLVDDVGSEAVPKFTYIPHNIVYQSAYLHVSLARISDEDCCANCKGNCLSADFPCTCARETSGEYAYTKEGLLKEKFLDTCLKMKKEPDSFPKVYCKDCPLERDHDKGTYGKCDGHLIRKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGSEKDLKDEEALCLDATICGNVARFINHRCEDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKAFRCCCGSESCRDRKIKGSQGKSIERRKIVSAKKQQGSKEVSKKRK
The following text describes a protein:
Function:
Part of the ABC transporter complex PstSACB involved in phosphate import.
Sequence:
MKLQSASLTALSLTIALALAACSPGKDAQSGDPAQGGANAGAAAGESKSAEIAGAGASFIYPLVSKWSADYNAATGNKVNYQSIGSGGGIAQIKAGTVDFGSSDKPLDSAELQQAGLGQFPSAIGGVVPVVNIEGMAPGKLRLTGALLGDIFLGKVTMWNDAAIAAANPGVTLPATKINLVHRSDGSGTTFNFSNYLSKVSPEWKTKVGEGTSVQWPGGVGGKGNEGVASYVQQIKGSIGYVELAYALQNKMPYASMQNAAGQWVEPNAESFGAAAASADWTNAKDFNLVITNAPGEKAWPITATNFMLMHKQPKDAARSKATLDFFKWALENGQAQASELHYVPLPPELVKQIEAYWGSEFK
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters.
Sequence:
MSLQADFDKAAKDVRKLKTRPDDEELKELYGLYKQSVIGDIDIECPALLDLKGKAKWEAWNLQKGLSKEDAMNAYISKAKELIEKYGI
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins (By similarity).
Sequence:
MGARPSRRQMTEARRLALTKLPPELLVQVLSHVPPRALVTRCRPVCRAWRDLVDGPSIWLLQLARDRSAEGRALYALAQRCPADADADADADGNRHDEFPFCALARFCLRAPFGRNLIHNSCGEQGFRGWEVEHGGNGWAVEKNLTLVPGAPSQTCFVTSFEWCSKRQLVDLVKEGVWQELLDSGQIEICIADWWGARENCGCIYRLRVRLLDEYENEVVKFSASPNPVLQWTERSCRQVSHVFTNFGKGIRYVSFEQYGRDTRSWVGHYGALVTHSSVRVRIRLS
The following text describes a protein:
Function:
Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.
Sequence:
MNKTIGILAHVDAGKTTFAEQILYHTKSIKSRGRVDHKSSFLDNHKIEKERGITVFSEQGTFQYKDSTYYLIDTPGHMDFSSEMERAIKVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANAENVIEEIKLNFTKKAFFIDKSLSNEECSSELIEFIAEQDECLLEKYLEDNYDKELWLNSMKKLIKSNKIFPCFSGSALQDIGIEEFLENLHTLSYTEYNEEEKFSGRVYKIRHDEQKNRLTYVKALSGSLKVKDEIALPNIEDDFCEKVNEIRIYNGDKYINVDKAEAGQIFAVTGLNSANVGDGIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILEAEDPSLNIIWNEKFQEIQVYIMGVIQLEVLKNLMEERFHISIDFGPCEILYKETILDTVIGYGHFEPLGHYSEVHFKLEPGERNSGITFENLCHTDDLTVGNQNLVRTHIFEREHHGILTGSPITDINITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPYYSFKMEVPLDCMGRVLSDIQKLKGSFNPPETIENRVIIKGRGPVATFMNYSVEFISFTKGKGKFNFIFDGYDICHNEKDIIEKIAYDKNADIEYTSTSIFCSKGQAFLVKYDEADGYMHCLK
The following text describes a protein:
Function:
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (By similarity). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS.
Sequence:
MEEREGGFRKETVERLLRLHFRDGRTRVNGDALLLMAELLKVFVREAAARAARQAQAEDLEKVDIEHVEKVLPQLLLDFV
The following text describes a protein:
Function:
May play a role in cell-cell recognition and signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAGKMRPVLWILCAVWVTVNAISVQTPTDVLRAARGKSVTLPCTYLTTATDRKGLIQWDKLLMTHTERVLVWIFSSKSTVYGELYENRVNISSKVDQSDASITISQLTMDDNGTYECSVSLESDLTGTSKSRVRLLVLVPPSKPDCGIQGETVIGNDIQLTCQSQEGSPAPQYSWRSYDQRNQERTGPAVTGQTFSLKNISTDMSGYYICTSSNEMGSQSCNITVAVRPPSMNVALYAGVAAGVAAALILLGVLVYCCCCRGKSEDPDAEDARPKREAYQQPAQQMRELSRGQDEEDGSRHEDQRSDGHESPDHTGQ
The following text describes a protein:
Function:
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
Sequence:
MVSGHLFHCRKNSWPPEEYVGRTALQLLDLDGGSPPEQAWRRRLNSHANILKEFSVTFMEAMKMMTLGVRLWSYVREEASHGRKAPIDPFTRERCKPSASQGVPLGGMGSGSISRGFRGEFKNWHIIPGLCENSPVMENQFSIFVSRDSGNKKYSSVLAPGHHEGLKKCNDSGISSWDWNLSGQHSTYHALFPRAWTIYDGEPDPDLKISCRQISPFIPHDYKDSSLPASVFVYTLVNTGRDRAKVSLLMTWANSIGGFSHHSGGHFNEPFIGDDGVSGVLLHHKTAKDNPPVTFSIAACETQNVSVTVLPVFGLSGENHVSAKEMWDTMSKDGHFSRENFNAGCSMPSSSGETLCAAVSASTWVEPHGRCTVAFALAWSSPKVKFQKGCTYNRRYTEFYGTSERSSSINLVHDALTKYRLWEEEIEKWQDPILKDEKLPEWYKFTLFNELYFLVAGGTVWTDGQPPAFGETSPAYQHKHSKKGTKSESVKDNHVKPAAEQVSDGDDPPNGEERSVSMYAAVHGSQMPEQTSGLRSQEPIPYLLSKDGPENVGKFLYLEGVEYIMWNTYDVHFYASFALLDLFPKIELSIQRDFADAVLYEDRRRVKFLADGTSGIRKVKGAVPHDLGTHDPWHEMNAYNIHDTSKWKDLNPKFVLQVYRDFAATGDMTFGRDVWAAVCAAMDYMDQFDRDCDGLIENDGFPDQTYDAWTVHGISAYCGGLWLAALQAAATMAHRLGDRPYAEKYKLKFMKAKAVYEAKLWNGSYFNYDSGTSSNSRSIQADQLAGQWYAASSGLPPIFDEHKIRSALQKIFEFNVMKVKGGRMGAVNGMTPKGKVDETCMQSREIWTGVTYGVAANMLLHGMEHQGFITAEGIFLAGWSEDGYGYWFQTPEGWTTDGHYRSLVYMRPLAIWAMQWALSPPKAILEAPKVNLMDRIHISPQAVRAVGEIGVRKIAPDNRCIPSSTFQCEC
The following text describes a protein:
Function:
Probable RNA-binding protein.
Sequence:
MADGFWNRQQQHLPPPGGMLKRPRTEYDTAPSGVTSGNEVHNYIAQNNGHQMLNDTKILGSAYDRFLQSAGLTSFNSGEASVIGGVGFARGVGELPGHSLGDPSAMGHLSGVGGGPDLSRNGRDVNFGGQLPIDAVSRPGPETIPLPRDASSTLYVEGLPSDSTKREVAHIFRPFVGYREVRLVAKESKHRGGDPLILCFVDFANPACAATALSALQGYKVDEINPESSYLRLQFSRSPGRRSGGPGPRGKR
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MEEQIVHGDGLLVNLANEVKLEEDEEDFCSCCEDEEDLEETALKEEEDEVTKEEKELLVRESCEVDLDEHSIKLFFKGISIAGPGDSGCRISGIGVVMERAESVPPIQIQKKLDFYVEEFVADYLALMDGLLEAVKNKIRKVYAFTDSEILYQQIMHEESLDNPLLMALRQRILDHADDLEAFVLKLVPSTGLAKALDLAKVAIGIVSSHLEGDESTENCPICCEDRLLLMMSTLKCTHKFCSHCMRTYVEGKVQSGQVPIRCPQLKCKYLISATECISFLPLNSYESLVRALEEANALNSDKLYCPYPNCSVLLDPHECLSTRASSSSQSEDSCVECPVCQRFMCVDCRVPWHSSMTCEVYQNLPLEEREAGDITLHRLAQNKRWRRCSQCRRMIELAHGCYHMTCWCGHEFCYSCGAEYRDSQQTCQCAFWDEDYTRDLVTQPTQQFEQWAWDSFESLPMMMDAYSDEERSQLALIQRFLAGGFSLTDHQAYQSPPRCTDSYVDAMKDLHQLPWLERFVSVISDNYYEEHIQ
The following text describes a protein:
Function:
Polysaccharide-binding protein present at the surface of the cell. Probably mediates xyloglucan-binding before xyloglucan transport in the periplasm for degradation.
Miscellaneous:
MISCELLANEOUS: Gut bacteria supply the human body with energy from dietary polysaccharides through glycosidases that are absent in the human genome. Xyloglucans are a ubiquitous family of highly branched plant cell wall polysaccharides present in the vegetables we consume. Enzymes involved in xyloglucan degradation mediate the conversion of otherwise indigestible plant polysaccharides to short-chain fatty acids.
Subcellular Localization:
Cell outer membrane; Lipid-anchor. Note=Cell outer membrane localization is predicted by analogy with the archetypal sus locus.
Sequence:
MRIFMKSKLLVIATTALLFAACSDSFLDRAPEGNYVDATFYTSDEALEAATAPLYNRAWFDYNQRSIVPIGSGRANDMYSPWNYPQFVTFQVTALDENLSGAWSGFYSVVTMANSVINAVETQTQGSVSEAAKTKAIAEARLMRACAYFYMLRIWGPVILIEDNQKLVDNPVRPLNREEDVFQFIINDLNYAVDNLSEQSDKGRATSWAAKGILAKVYLARSGWNNGGTRDEGDLELARQYASDVCENSGLDLMTNYEDLFKYKNNNNQESLLAMQWVPLGEWYECNTLLSDLAFSTEVTGGVNCWSSYNGSIDMLQQYELADTLRRNATFFTKGSYYSYICIKDGGYTYKGTASPIKKGVPGGPDDDNDGKVKQMNSPLNTYILRLADVYLTYAEACLGNNSTLSDGRGLYFFNRVRERAKINKKSSITLDDIIRERRVEFGMEYSNWYDMVTWFRYLPDKMLNYFNNQWRGYRTDAIIKDEDGKLHFGKYDTDGTTFLEGPEYYTAPEFTINIEAEDIFLPYPESDVIQNPLLNEPPVPYTFNE