lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSKIELGLCGEILKEHFGSLVQKVGFVLLSKGRSNLAAIAQSSKLPIKIIRESLFILIQNHQVTFAENTEGMRVVVYYEANIKEILLRDRFALYISTASTHLGVNAGLIISKVLEAGYLAPLKLLKSCKLTEKDISACMEKLVQGRFVRTVSAIDSLTINDKYILEEREAIANTGAGAPLSSTELAKLRKSLAEKRSNYAQTPSSGTKRKVLDFEEEENRKKIAELASQRVNDTAGRLIKAMLDHTYSQLNSCKEPLSPSIRREMIGTLVRGQELHVHGHSNDPAMEYIEALVSERAKIVSNLNGTLYAINLRDSVRVMQIDLIESIIQEKFGDVCRRIWRLLYMKQKLDEKQVGKQAMINNKVARECLYTMLKEGLVYLQDVPKTMDHSASRTFFLWYVSIERTCTVLLTNAYKTLHRIKLRRTKELLDRTLLLEKTNRSDVLSGEAQLTTTDQENLAHLNTVLKKLHISEMRIDQMVMLLRDF
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAAIASSDASVRICLVTRSSSLASAVRFCCVAASPSPALPFILGFGRKTLSKMLAKVTRASLPLRSARALSTVVEEEVRKFNAASSDWWKPRSTTGVGPLHQINPVRVKYIRSHVIEHFGSSSDDDPTPLRGLRVADVGCGGGILSEALSRIGGTMVSADPGEDNIAAAKQHAALSRYTSSIDYRCCTSGEAALSSGVVDDLVAQGEQFDVVCSLEVIEHVSDVTAFLHSLTPLVKPGGLLFLSSINRTPLSAALAIGAAEYVMQIVPPGTHDWNKFVRPSEIEAVLREEGLTVKDLSGIVGDPIFRSWRIHPTCTDINYVMCATKPQQ
The following text describes a protein:
Function:
May be involved in vascular wall and kidney homeostasis.
Subcellular Localization:
Secreted.
Sequence:
MKPLIIVLLAITATLARKGFGPTDQEWGFVDVREGAHMFWWLHKTAANVDKYTDKPLVVWLQGGPGASSTGYGNFGELGPLDADLNPRNTTWINDYNVLFVDNPVGTGYSYVNDSKYFATNNSQIASDFVTLLKGFYEAVPDLKQTPLHIFSESYGGKMTAEIGLQIYLATKSGDLDCHLVSVGLGDSWISPIDSVLTWGPYLLTVGAVDQNQYEQVQAKAEETKAALEAGKFSEATNLWGQAEQVIETVTAGIDFYNILKKITASWVKKEKALPGLKDDDVDTKIAILMNNDVKKALGLEVDWGFQAGAVFDALYEDFMKPVTNIVERLLNETDVRVAVYNGQLDLIVDTPGTTQWVDKLQFPGSDEWKTASKLAIKVDKIVEGYYKNLGNLTMFWVDRAGHMVPADNPAAMSYILQYMTKNV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Subcellular Localization:
Cytoplasm.
Sequence:
MELSKYIKKVKLNKLEAKEKFVITIGVFDGLHLGHSSIVDELVNNALLNGFNSGVITFENAFSQNLKKISSFLLTYDEKINLLSLKGVDYSIILPFSKEIKNLSSEDFIKVLLNTIPISCICVGSNFFFGKDRMGNINTLLSLGEKYNFNVKIVPLEKGNSDIISSSHIRNLLLNGEINMANDLLGYKYFINGVVEKGDNLGSKIGFPTVNVKYNKEKLIPKAGIYKGKVKIKKNIYNAAIYIGKRPTFHGKELRVEAYIIDFSDYLYGEEIEIALEDYIRPDQKFDSIEALKRQIQKDLQAIEDKIKKEENNIKIITIDGTAGSGKTTIAKFIAEKLKFDYIDSGALYRAVGLITKEKNLSTEEEIIGFLYQNPIKFNFEDKIFRVYISDREITSMIRTEEIGKYASIVGRMPRVREFLTSYQREFLRKVKKGLVLEGRDSGTVVFPNANLKLFVNANIDIRAQRRARDLSERDIERIKKYIIERDKQDMNRDIAPLRFPNHGYFIDNSESPLEEIYDKIISLYLKAL
The following text describes a protein:
Function:
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
Subcellular Localization:
Cell inner membrane. Cell membrane; Single-pass membrane protein.
Sequence:
MTMVNRMADKEKLSALMDGEMIDNELILGLAQDQDARDTWKNYHLIGDVLRGEAPIHKEWNIAESVALALENEPAHNPLHHSTNVIDLQQARLEAQPKPQQAKRQLPAWLSQFGQVGIAACVSLAVIFGVQQYGGQSSGVENELPVLQTIPLAGSAEPVSLTRDSVEKHAPDSSMQEQRRRVNALLQDYELQLRLNSENSASHQHPVESVVE
The following text describes a protein:
Function:
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). May play a role in cell-cell interactions (By similarity).
Miscellaneous:
MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Note=Concentrates at sites of cell-cell contact. Shows an intracellular localization.
Sequence:
MLRKQAGEEDSVVLIDMTSPEAGNGCSYGSTAQASEAGKQQVAPSRVGSSANPPIDFVLVWEEDLRSRENPTQDKTDTHEIWRETFLENLRVAGLKIDQRDVQDEAAAVHYILLSAPWAVLCYYAEDLRLKLPLQELPNQASNWSATLLEWLGIPNILLENVPDTPPEYYSCQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGHQKKGLFGIDQLLAEGVFSAAFPLHDGPFSVVPESSQVLGLTQRQVLFKHWARWGKWRKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTVVFLAGCFLVFSDVPTQELCHSSDTFDMCPLCSDCSFWLLSSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPRPQFAATAPMTALNPITGEDEPYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSIILYRAVMAIIVSKSNNAFLSAWASRIASLTGSVVNLVFILILSKVYVILAQVLTRWEMHRTQTAFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGNYHTLFGVRNEECPAGGCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKLCSRRKKAGMGANPAPWEADYELLPCEGLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRVYYSWTRAPDLRGFLNFTLARAPPTFTSAHNRTCRYRAFRDDDGHYSPTYWTLLAIRLAFVIVFEHVVFSTGRFLDLLVPDIPESVEIKVKREYYLAKQALADNEALLGATGVKGEQPPSSEPSLGLPA
The following text describes a protein:
Function:
Catalyzes the reduction of D-fructuronate (D-FruA) to D-mannonate (D-ManA).
Sequence:
MRLNRETIKDRAAWEKIGVRPPYFDLDEVEKNTKEQPKWVHFGGGNIFRGFVAAVLQNLLEEGKEDTGINVIELFDYEVIDKVYKPYDNLSIAVTIKPDGDFEKRIIASVMEALKGDPSHPDWERAKEIFRNPSLQLASLTITEKGYNIEDQAGNLFPQVMEDMKNGPVSPQTSMGKVAALLYERFKAGRLPIALLSLDNFSRNGEKLYSSVKRISEEWVKSGLVEKDFIDYLEKDVAFPWSMIDKIVPGPSEFIKEHLEKLGIEGMEIFVTSKRTHIAPFVNMEWAQYLVIEDSFPNGRPKLEGADRNVFLTDRETVEKAERMKVTTCLNPLHTALAIFGCLLGYKKIADEMKDPLLKKLVEGVGEEGIKVVVDPGIINPREFLNEVINIRLPNPYLPDTPQRIATDTSQKMPIRFGETIKAYHERPDLDPRNLKYIPLVIAGWCRYLMGIDDEGREMQLSPDPLLENLRSYVSKIKFGDPESTDDHLKPILSSQQLFRVNLYEVGLGEKIEELFKKMITGPRAVRKTLEEVVGREDG
The following text describes a protein:
Function:
High-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGVWESVKDFRKYSNQYLAAFTGTLLMLSVAASYGWTSPTLPLLLSDDSPLPITPDESSWIVSILVLTSIAGPVATAWLIDGFGRKVTLLIAVLPSIVGWILIGVGESVTVLYISRALSGISYGMAYSSMPLYLGEIASDRIRGSIGTLLTVMAKSGILLEYVIGPYVDYRTLAWISVAFPTTFFALFLWLPESPYYLLAKQRNEQAEKNLRWLRRASDVQDELRMMQAAVERSQQNRGTFRDLLTRGNRRSLIIILGLGALQQLCGSQAVIAYSQQIFDQVNSGLKAHESSIIMAVIQLVTAALSSSIVDRVGRRPLLLISTVGCAVGTFIVGLYFFLLQQEVDVEGVGWIPLAVIMIYIVFYTVGLATVPFAILGEIFPTNVKAVAAAIYTMFAGSVGFGVSKLYQLISDEAGTYVSFWIFAACSAAFVVFVFALVPETKGKPLDQILIEMHTSTTRSLNCCSGSEKKKPDLQHGA
The following text describes a protein:
Function:
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Has a shorter cytoplasmic region; MISCELLANEOUS: [Isoform 4]: Secreted; MISCELLANEOUS: [Isoform 5]: Has a longer cytoplasmic region; MISCELLANEOUS: [Isoform 6]: Has a longer cytoplasmic region; MISCELLANEOUS: [Isoform 7]: Has a shorter cytoplasmic region.
Subcellular Localization:
[Isoform 3]: Cell membrane; Lipid-anchor, GPI-anchor; [Isoform 4]: Secreted.
Sequence:
MKRGRPAALRCLLLLRAPALLLLLRAAAVQGDCGPLPVVPRAHPASASAGSTSFPENTTVLYTCDQGFVKIPGKPDAVVCISSRWTDIEEFCNRSCEVPPRLPYAILKSAYISKNYFPVDTVVEYECRPGYRKKYPIQSGKITCRDDLTWSTPAEFCEKKQCPNPGELVNGNINVTTDLLLGSQIFFSCDPGYRLTGEASAFCMIKGNAVGWSSSLPTCIKIICPEPPQIENGRIVNEEDTYEYRHVVTYECNKGFVLTGKSHISCIVRDDVGEWSDPPPTCRVKSPPVIPPQKPTTTSAPGTTTTLPTQKPTTVNTAGPEVPTTQRSTTVNVPGTKVPTTQRSTTVNVPGTEVPTTWKSTTVNVPAAGNRPDTRTTIKSTTASEEKDLASGYRTFLYGVGVGVPVIVCSLGLGVYWWIHRTSGQYETYENKESNVICHNLNESDATSEITSSDKLKKTHVYKVDSFACGASNHWLADIAKEDLRRDFSNAQNISSLLQVLGAAQTQ
The following text describes a protein:
Function:
Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MVGKYFHKGHATANGIAISGTGVSMFVLSPLSQFLIDEYRWNGALLIFAGITLNGCVCGALLRPLHLEGAGKVEEAETENEEATDSSKTCEAVVLLCRRVVEMFDVTLLKSRQFLVYSLSFFGLMLGYSMSFPHLVSHAQGLGVEKTQAAFLLSILGIVETVARPVNGWLSDRLPVRKLYYYMVGCVGLGICNVAIPHSRTYAALVACMVFYGISSGIFYPLIAVLAKKYSGVSRIGGGLGWAFVFKGVAFLLGPPIAGWLYDATGNYDMSFYAAATFIFASVAVLLLLVPKKGKSWALESGRPAADVPHDECDGVVGLQAIQLSFDTVTTVGQNNPVFEREM
The following text describes a protein:
Function:
Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. The SAGA complex predominantly acetylates histone H3.
Miscellaneous:
MISCELLANEOUS: One of a pair of almost identical proteins differing at a single amino acid position expressed from genes (Ada1-1 and Ada1-2) resulting from a gene duplication.
Subcellular Localization:
Nucleus.
Sequence:
MLTDRVLATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKIDAFAPLENPPAVQTSSSSGNRSKRRKRSCRTFAERLNFELSDVLDFVAEDNMQIIRPPTTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLKDLLSAIIKKRKHYKTSGEGNFYYDVGAPLRDPSLRNTVTRQKVDDTPLELDKELNTANFMRRQNDDVTFLSACEEVQPTERTVITLKDCQLALRDRNLIGSHAVYSINMERLNMMMH
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MKLYKVLNSKTTDKSLCLEVEIDPNYWQATQKKLVGEMAKSIKIKGFRPGKIPPNLASQSINKAELMQKSAQNVMNSIYESVQQEEIVASNDNVIDDYPTIDFKTITEQNCVLLFYFDLIPNFQLPDYKKIKDLTPLTKLTEAEFNNEIEKLAKTKSTMVDVSDKKLANGDIAIIDFTGIVDNKKLASASAQNYELTIGSNSFIKGFETGLIAMKVNQKKTLALTFPSDYHVKELQSKPVTFEVVLKAIKKLEFTPMDETNFKSFLPEQFQSFTSLKAFKSYFHKLMENKKQETILQENNQKIRQFLLTNTKLPFLPEALIKLEANRLLKLQQSQAEQYKIPFEKLLSASNITLTELQDRNIKEAKENVTFALVMKKIADIEKIKVDNNKIKAEIENVIAVEYPFASDEMKKQLFFNMEQQKEFVESIIINRLTTTKIVSYSTH
The following text describes a protein:
Function:
Required for proper maturation of seed storage proteins. Forms a complex with MAG2, ZW10/MIP1 and MIP2 on the endoplasmic reticulum that may be responsible for efficient transport of seed storage proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MALIDVAISCLNSIREIEEDVKDAIVYIDAGCTESFQFVGAFPLFLELGARAVCSLENMTSLDAVADWNSKSDCAKRIVIMTSRLLNDAHRYMLRCLSTHEGVQRCTVFTSISEGSHSAIPDSPLGPDAYREYETLLVQDYNEHTKKSDKISKDKGVSKFSSALESLTMEPIESENVDISSGGAQGLVVSVHHFPLIICPFTPRAFVLPSQGSVAEASLSRQHEDSLSFGLPPISTGSMSDTDDVPPGATLTAHFLYQLALKMELKLEIFSLGDQSKNVGKILTDMSSVYDVARRKRSAGLLLVDRTLDLITPCCHGDSLFDRIFSSLPRAERFSSQAQLKQGVPSINRPSLDVQVPLGELLNEEPSKIRDSGLPEGIEAFLRGWDSYTSAPQNVGLFNECDKKSTTNWTELLNGSLVATECFRGTPYLEAMIDRKTKDGSVLVKKWLQEALRRENISVNVRARPGYATKPELQAMIKALSQSQSSLLKNKGIIQLGAATAAALDESQSAKWDTFSSAEMMLNVSAGDTSQGLAAQISDLINKSAVAELQAKKNEKPDSSSRGLLSFRDALLLTIVGYILAGENFPTSGSGGPFSWQEEHFLKEAIVDAVLENPSAGNLKFLNGLTEELEGRLNRLKSEETKEIPSDDQLDIDALDDDPWGKWGDEEEEEVDNSKADESYDDMQLKLDLRDRVDSLFRFLHKLSSLRTRNLPLREGSLASESSFPGEPSGNKGLVYRLITKVLSKQEIPGLEYHSSTVGRFIKSGFGRFGLGQAKPSLADQSVILVFVIGGINGIEVLEAQEAVSESGRPDINLVIGGTTLLTPDDMFELLLGQFSHF
The following text describes a protein:
Function:
May act as a negative regulator of ASF1 in chromatin assembly.
Subcellular Localization:
Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.
Sequence:
MAAVLESLLREEVSVAAVVRWIARSTQGSEDNAGEAAALSSLRALRKEFVPFLLNFLREQSSRVLPQGPPTPAKTPGASAALPGRPGGPPRGSRGARSQLFPPTEAQSTAAEAPLARRGGRRRGPGPARERGGRGLEEGVSGESLPGAGGRRLRGSGSPSRPSLTLSDPPNLSNLEEFPPVGSVPPGPTGTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKERSKQLQQSPTPTCPTPELGSPLPSRTGSLTDEPADPARVSSRQRLELVALVYSSCIAENLVPNLFLELFFVFQLLTARRMVTAKDSDPELSPAVLDSLESPLFQSIHDCVFFAVQVLECHFQVLSNLDKGTLKLLAENERLLCFSPALQGRLRAAYEGSVAKVSLVMPPSTQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLSMLGADKLGRLWRLQERLMAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIQELNGLALPQHEPNDEDGESDVDWQGERKQFAVVLLSLRLLAKFLGFVAFLPYRGPEPPPTGELQDSILALRSQVPPVLDVRTLLQRGLQARRAVLTVPWLVEFLSFADHVVPLLEYYRDIFTLLLRLHRSLVLSQESEGKMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGPSYAFEVDTVAPEHGLDNAPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFMRKITPTTTTSLGAQPSQTSQGLQAQLAQAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVRQAESLLQEQLVTQGEEGGDPAQLLEILCSQLCPHGAQALALGREFCQRKSPGAVRALLPEETPAAVLSSAENIAVGLATEKACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISEIKDVLSLAVGPRDPDEGVSPEHLEQLLGQLGQTLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQYRLERGQARRLLHMLLSLWKEDFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKGLMGRMEIEACLGSLHQAQWPGDFAEELATLSNLFLAEPHLPEPQLRACELVQPNRGTVLAQS
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MVIANYGFLEHPLCVPQDSLECLGMMNWEGMDSIDSMFSTPWESEKERLEQPEKDKTERKSFTDVSNNQANHMSLLTRLDDESNLAAEKSQTKILKTKNIAARSLSKCKIDFLNSTQSGRDAKIWEKRCGHKDARIWERRCSHCDAIKTPQWRTGPFGRNTLCNACGIRFKAGKLYPEYRPADSPTFDVSKHSNVHKEIMKMRNHLS
The following text describes a protein:
Function:
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23.
Subcellular Localization:
Secreted.
Sequence:
MKVSVAALSCLMLVTALGSQARVTKDAETEFMMSKLPLENPVLLDRFHATSADCCISYTPRSIPCSLLESYFETNSECSKPGVIFLTKKGRRFCANPSDKQVQVCMRMLKLDTRIKTRKN
The following text describes a protein:
Function:
May function in vitro as a polymerase that catalyzes the polymerization of the O-antigen repeat units on the periplasmic face of the inner membrane, leading to the formation of the lipid-linked O-antigen molecule (Probable). However, E.coli K12 strains do not normally produce the O-antigen in vivo due to mutations in the rfb gene cluster (Probable). K12 strains are phenotypically rough, their lipopolysaccharide having a complete core structure, but no O-antigen (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIYLVISVFLITAFICLYLKKDIFYPAVCVNIIFALVLLGYEITSDIYAFQLNDATLIFLLCNVLTFTLSCLLTESVLDLNIRKVNNAIYSIPSKKVHNVGLLVISFSMIYICMRLSNYQFGTSLLSYMNLIRDADVEDTSRNFSAYMQPIILTTFALFIWSKKFTNTKVSKTFTLLVFIVFIFAIILNTGKQIVFMVIISYAFIVGVNRVKHYVYLITAVGVLFSLYMLFLRGLPGGMAYYLSMYLVSPIIAFQEFYFQQVSNSASSHVFWFFERLMGLLTGGVSMSLHKEFVWVGLPTNVYTAFSDYVYISAELSYLMMVIHGCISGVLWRLSRNYISVKIFYSYFIYTFSFIFYHESFMTNISSWIQITLCIIVFSQFLKAQKIK
The following text describes a protein:
Function:
Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity); [Circumsporozoite protein C-terminus]: In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasm. Note=Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.
Domain:
The N-terminus is involved in the initial binding to heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity). The N-terminus masks the TSP type-1 (TSR) domain which maintains the sporozoites in a migratory state, enabling them to complete their journey to the salivary gland in the mosquito vector and then to the host liver. The unmasking of the TSP type-1 (TSR) domain when the sporozoite interacts with the host hepatocyte also protects sporozoites from host antibodies (By similarity); The TSP type-1 (TSR) domain is required for sporozoite development and invasion. CSP has two conformational states, an adhesive conformation in which the TSP type-1 (TSR) domain is exposed and a nonadhesive conformation in which the TSR is masked by the N-terminus. TSR-exposed conformation occurs during sporozoite development in the oocyst in the mosquito vector and during host hepatocyte invasion. TSR-masked conformation occurs during sporozoite migration through the hemolymph to salivary glands in the mosquito vector and in the host dermis; The GPI-anchor is essential for cell membrane localization and for sporozoite formation inside the oocyst.
Sequence:
MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKIKNSISTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSFLFLN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates.
Sequence:
MKRARQEPILDKIQRFRGVILVFAVPLILVSFVLFLMPRSPAVISFASRKTMPGGSEAGSKSYAVIFDAGSSGSRVHVFCFDENLDLLPIGQELELFVQKKPGLSFYAKDPQQAAQSLVSLLEKAESVVPMKLRQQTPVRVGATAGLRALGAETSEKILQAVKDLLQHKSSLKFKSDWVTVLDGTQEGAFQWVTINYLLGKLGKSYANTVGVVDLGGGSVQMAYAISEKDAEQAPKVSDGEDSYVQKLFLKGTKYYLYVHSYLRYGLLAARAEILKVTKDDSNCILSGYHGSYKYGGNAYRASAKQSGASFLKCREDAVKALRVDEPACTHMKCTFGGIWNGGGGDGQKNLFVASFFFDRAAEAGFVDREKPIAVVKPSHFEKAAKHACQLSIEDAKAAYPRVQEDNLPYLCMDLVYQYTLLVDGFAIDPDHDITLVKQVKYGDAFVEAAWPLGSAIEVASSA
The following text describes a protein:
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
Subcellular Localization:
Cytoplasm.
Sequence:
PPIAAAALRLRRWVVARGFEPRRRGAAHGAGASDASPDEGVEADLPIIDERAVEQLTEGLISHYLPDLQRSKAALQELTQNQVVLLETLEQEITKFRECNSILDINALFSEAKHYHSKLVNIRNDMMMLHEKTSKLKKRALKLQQKRQKEELEREQQREKELEREKQLTAKPARRT
The following text describes a protein:
Function:
Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. Required for efficient chromosome segregation. Restores protein transport and ribosomal RNA stability.
Miscellaneous:
MISCELLANEOUS: Present with 2120 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMGFEWGFKPSSKITQSTVSSQGTGNVMIPTAGVKQKRRYANEEQEEEELPRNKNVMKYGGVSKRRPQPGSLIRGQPLPLQRGMELMNKNQLQQLLVDLMTKHPEIQQSVHTRVIGLDFSIQKCLDMLKQKSEAVYQSIPYNRSYESNKLDDYAFVRMKPQILEFLNCLVDFILDNIPPRLENLHASLKFLDICTELVIKLPRFELASNNYYYDKCIEQLSHVWCTLIEHVARDRIILLADNSSVWKSHMTRLQVYNEHSNGLLERPLQLFKSLDMGSPSAASSSTLSLQESIIYHHDTMTANENNNNSGSAATDSPFN
The following text describes a protein:
Function:
Forms a receptor-activated non-selective calcium permeant cation channel. Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVALPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFWNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWVCSHTSKGKVRRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPKN