lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MTNDVEMKTEQEELPVFPTVHVLQVVKDAQQQHGLRHGDYARYRKYCAAKLERMRKAMKFTNTHNCQKRRPAKFVKKWLNAEAIHNVQYLNFGIFESERRYAEAMIDKITLEDNPEKSRKRFTMINSLRKAVLHVTNLEKIVQESDRFDAPTKLEAQAYAAWMRGMCAFESRNWQKASESLKLAKTVYEKLAEATNNTTLSSLFKGRCREIQPQLRLCEFNIAESPGAVGTMTELMELRMQMGEGGDSSVDKLISEMRASATSAEFVTIEWGGMKSTVDDDKAKQVIQEWKQTEIELAQCQTPKERMALFEKATADTRDAIDRISDIIRRKSISGILKMNGTASRYLAIIDNTKSEKKNKPQDLLRLYDSVIEIYKEVSETPGAEYDKNLIEAFEVKVEYYRAFRCFYMSSSYSALHKYSEAAALFDRTLSRIQEAEGKLKKLKSNFYITNETAQSLNELRSEVDAAKISARAARLAAAAGDIKTDSEVAKTIDERPLLETVNEWRQWNVRESLRDKKTIPVASLPPAFIPMPNKPIFFDLANFHLTMPDVEDRLEKLQKDRDAQTPKKTGKGGSAAPNTSASKEGEGQQGISGMVTGWFWGKK
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MDIRELRYFAAVYRARNLTAAARACFVSQPSISTAITNLEAELGTTLFIRHKKGVAPTASAEQFHALARRIIDESDAARSLFRKQATRTTVTLGLMRTLDVPRTIALLKPLTARSDIALRLVGSDERADARIISKSMLRADEHFVALWSERYVAALPPSHPLTLKEKLRAADLAGAAMIDRCHCEQSQFFGRAAQRRQTAAIAQSEDWAMALVAAGIGIAIVPEGVARGNPDVAVREIEVKVKREVGLAYRASVPLADALKDLVGKLQKQRRKPDRIARQRSVRKTLSPSR
The following text describes a protein:
Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane. Mitochondrion matrix.
Sequence:
MADGGTATMQTSNRSYEDAVVAMNSLITPTADLPPRDPTTGALNWNAHFRSFFRFIEILEMKEPLARLSVIHVAGTKGKGSTCAFTERMLRESGFRTGLFTSPHLLDVRERFRFNGEMISKDRFLYHFWWCWDRLQANNADLPGFFRFCTLLGLRMFTAEKVDVAILEVGLGGRLDATNIVESPVVCGIASLGYDHMELLGNTLAEIAWEKAGIFKAGVPAFTAPQPEEAMGSLQKRARELGITLKVAPALEDYGLSDLQLGLGGEHQRINAALAVALCKQWVMTRAPSEQHKELQKILGGGILPDSFVKGLQLTKWAGRAEVIHDPSGRLSFYIDGAHSPESMEACANWFCSRIKHEETTEVVQSSSNPERWNSKGFIMRRVLLFNCMPKRDPVLLLQPVINLCSKNGFPIHAAFFVPPYSSYTSVGTSHQAPTVTDATWQHTLQRHWESLWRDKLTDGSGFACLSRGERREPEIELLSTLKDASECNPQHGNMLGPSSAVLRSLPSALDHFRNCLTHHPQLRVQVLVTGSLYLVGDLLKLLKR
The following text describes a protein:
Function:
Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation.
Sequence:
MSLAWLRNHARHRERGTTRTRSNSQRLAAQRAHRQFAGAEAYAPRVTYDNSFVVDSSVTSRDANWASDDQYKRQYRRLGWEVAPIRKDGNCLFRALSDQLYGHERRHLELRRRLVDFIDLERVFFEPFVAGEGVVEYCERLREAGAWGGHPELVAASRLLGVTIIVHTGPVKRLRIDTDRFARTKEGKGKTLSLLLKHDHYSSLRKRDKPLDQQHGCSDMCLCRRIVTPSRASLDSRASLGTRPSDLGSSFDSDLSRRSSLGGAPDKRSRRPGGRGAYGRKPVPDADNSNVENSPKQQKAKPRSQPPPKPKAPAPAPPAHAKPAKPKTPAPATPVRAMAPAPPTKPKSPAPAPPSKPKAPAPAPPTRPQAPAPVQQKASSPRTKSTGPPTPKSVGVVLFQPESLKPVVKPKAPLVVLFEPEQTPVSKHTVSKKATVNTATPVKPTSAVVLEVEVEEPQSVSGQQAQVPKSSVHRPRRAVFNGGKRRRSSAAAFSLLQEVSTSLNAGRPEAAVEPVKAVPVVKAVKAVPVVKAVAVVKPVIKTVTVVKPAAPKPAPPAPRNMEIKKSSKKVFRQGRPVTAC
The following text describes a protein:
Function:
Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins smb1, smd1, smd2, smd3, sme1, smf1 and smg1 that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity). In the cytosol, the Sm proteins smd1, smd2, sme1, smf1 and smg1 are trapped in an inactive 6S pICln-Sm complex by the chaperone saf5 that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of saf5 from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes to the nucleus predominantly.
Sequence:
MITKIDSLPKDLIRKVENGEKLLPNQEIVYFEEKTVPYKIRSDEESFPLGKLITLLVTSQSFILFDEEQNSGWKIPYETITLHAKQSKDKPYVYVQLEGEAIRPLLDHILKFERSSGTLHEAPSTEDENEFTDDFLELTLYVTDVDSCYQALCTCQSLHPDTFSSDNDVENASMGNPMSLFFDPNHQWVTAENVDTSACDNRFDSPESPVLKWHRTE
The following text describes a protein:
Function:
Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLVPYIYCEKQEPGSMLCAQHALNNLMQSPVWSPQDLAEIARTLDSLERSHLQHDGGTHDNSLQGSSRLEKNSNYDDSGFFSVQVIDDALHRLGLRIIRWRSEEMKSMHDYPENQEAFILNHDLHWFTLRRFGHSVDRWYNLNSMDEASPKWIGPTFLSMAIAQAEAEGYSIFVVIPVPPSSEPSAPQPGSLLACQADEQAQLLDQLGYSSGGRSGSTSSGGASSTLRRPREEGTDEASRTRMRMNTEELPYDEQIRLAIEASLSQPSASEPSQTKSIDPQTAPDPSDSENNVEPPADSDLLDQLRSIEDEELAAAISESLANHPSDSDPTEPPSSSSLPPVSDDLIDEPTPEQLRQRRLARFS
The following text describes a protein:
Function:
Essential for the correct specification of ventral-dorsal patterns.
Subcellular Localization:
Nucleus.
Sequence:
MAANYKSCPLKKRPIVFVEERLPQTEALALTKDSQFAQDQPQDLSLKRGRDEETQDYQQPEPKRDYVLNLSKTPERNSSSSSNSCLLSPPVEAQDYLPTEIHMRGLTAGTTGYTTATPTTINPFQSAFVMAAGCNPISALWSSYQPHLAAFPSPASSMASPQSVYSYQQMTPPSSPGSDLETGSEPEDLSVRNDIPLPALFHLFDEAKSSSSGASVSSSSGYSYTPAMSASSASVAANHAKNYRFKCDECQKMYSTSMGLSKHRQFHCPAAECNQEKKTHSCEECGKLYTTIGALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFQCPDCPRSFADRSNLRAHQQTHVDVKKYACQVCHKSFSRMSLLNKHSSSNCTITIA
The following text describes a protein:
Function:
Mitogen-activated protein kinase kinase; part of the MST11-MST7-PMK1 MAP kinase (MAPK) cascade that is essential for appressorium formation, penetration and invasive growth. The MST11-MST7-PMK1 MAP kinase cascade transduces signals from the cell surface sensors MDB2 and SHO1 that recognize various surface signals such as surface hydrophobicity, cutin monomers, and rice leaf waxes. MST7 acts as the upstream MAPKK that directly phosphorylates MAP kinase PMK1.
Sequence:
MADPFAPRTMKRRNVKGLALTPAAPKPPPTAENAPIHRDSDQHAQLEIGIEFNLDLRPEDLEVIKDLGSGNGGTVSKVRHIPTNTVMARKVIHVEAKREMRKRIVRELQIMHSCNSEYIVTFYGAFLNENNDVIMCMEYADVGSLDRVSRVFGPIRVDVLGKIAEATLGGLTYLYAKHHIMHRDIKPSNILVNSRGSIKLCDFGVSGELINSIADTFVGTSTYMAPERIQGEKYTVKSDVWSFGLSIMELAIGKFPFAASEQLSDAESAPAGILDLLQQIVHEPAPKLPKSDAFPQILEDMIQKCLYKNPDDRPTPEELFERDPFVQAAKRTPVDLREWAFGLMERDNRKSHLAPQLSPATADLLRSSDSPTATYHGDDRPLETPTSAYRVDPRRGPAEGSAGLADQVDRLYIRD
The following text describes a protein:
Function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Sequence:
MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTLNIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPFFLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMTSENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFIEMSGAGLKESHPHDVQITNEAPNYSM
The following text describes a protein:
Function:
Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MNHYLFSESLMEQLKTLSTSWSLPVAAVVAAIGIFATMGLFSSKNHMPVEGRTVLLTGASEGMGRSAAIQLSQKGANVILVSRNVGRLEEALVDVRAAAKNPSTQRFTYISADVSEHDYAAAVLAEAIAWNGGRSPDIVWCVAGMSTPLLWTDDGSMAAARRNMDVNYFGSAEMSRAILREWLAPENSTGPNGEPKHLVFTASMLALFAILGYGPYTPTKWALRGLADTLAMEVNYYPDNPVKVHIVYPGTIVSPGYERENQTKPDITVELEKDEPAESPDTVARRAIAGLEAGKYFVDVSFLGRLMQCGIMGGSPRNNWVLDTLMGWLIPIIYFFVLRGMNSTIVKWAREKGHPFTHPKKK
The following text describes a protein:
Function:
Involved in spliceosome maturation and the first step of pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSSSESPKDGKPSSKPFSLSLSGSGSNGRSRKSAFNIPPARAAEPPSRTLARRPHRLHDDESDEEEAPPAFEDVAGFDTHTGTVLSADGRAVDKEKRELVIPVTSKNNWRDRVRANRGTRGKNLLPKEVQAMQEAERRGETAENDQETDRPSMSYGLSFAKPSQGEETKPGEDQAMKDAGPLKPQVVDERKPLTQDEIALQALIRESKGETEGRTDLVIESAKREVDESYPVRLDETGSFRVDVASRPEPATLDQYNAIPVEEFGAALLRGMGWKEGQSIGRGKYGTSATDYRSQSPRIPERRPGFLGIGAKDVSGGKGAEAELGAWGRAAMRKGARKAETQGGEGNTQGVYMPVLMRNKKTGEYITEEELTALKKEGKAKKGDDDWRERRDRNLEKSGRMDILVAETITTMTAIGLTDGGRVLHGETEVCHPVIDSPGGESTTMKTAAGETTVIIATEIETETGAIVSGIKIETGIGIERGVVTGAADIGMMIGIARDIHPLMRLAGTDVIETAIETLNGEDMMINVSENAGQCFGLDRT
The following text describes a protein:
Function:
During growth on glucose, RamB negatively controls the expression of aceA, aceB, ack and pta genes which are involved in acetate metabolism. RamB is also a negative regulator of rpf2 gene expression during growth on acetate as the sole carbon source.
Miscellaneous:
MISCELLANEOUS: C.glutamicum shows high-level specific activities of acetate kinase (Ack), phosphotransacetylase (Pta), isocitrate lyase (AceA) and malate synthase (AceB) when grown on acetate as sole carbon and energy sources. It shows low-level specific activities with all four enzymes when grown on glucose as sole carbon and energy sources.
Sequence:
MGKTYVGSRLRQLRRERDLSQASLAATLGLSASYVNQIEHDVRPLTVPVLLRITEAFGVDATFFSRDDDSRLLAEVQDVMLDREINPANVELQELSEMVYNHPQLARAMVEMHQRYRNVRDKFSIAVDNRTNTPEERRPIAEAVSMPHEEVRDFIYARQNYFDALDRRAEAIAAQLGWQPYDSRAMEDSIARRLQMDHDVTITSSKEESGTLHHFDPETRLLTIHARLNPGQRAFRMATELGYLEANDLIEGIVDDGIWSTPEARTLAIRGVASYFAAAVMLPYKIFHSEAEKSGYDIEYLGQLFGVGYETTAHRLSTLQRPNLRGIPFTFVRVDRAGNMSKRQSATGFHFTHYGGTCPLWNVFETFTNPGQVLRQFAQMPDGRNYLWISRTVRHHEARFGEVDKMFAIGLGCEARHADRTVYSRGFNLQDLSTATPIGSGCRVCTRENCAQRAFPSVHGRINIDAHESTIAPY
The following text describes a protein:
Function:
Acidic protein, which assembles histones into an octamer (in vitro). Involved in the regulation of the localization and the function of the septins during mitosis. Involved in the function of B-type cyclins.
Miscellaneous:
MISCELLANEOUS: Present with 8070 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Bud neck. Note=Phosphorylation by CK2 promotes the import into the nucleus.
Domain:
The acidic domains are probably involved in the interaction with histones.
Sequence:
MSDPIRTKPKSSMQIDNAPTPHNTPASVLNPSYLKNGNPVRAQAQEQDDKIGTINEEDILANQPLLLQSIQDRLGSLVGQDSGYVGGLPKNVKEKLLSLKTLQSELFEVEKEFQVEMFELENKFLQKYKPIWEQRSRIISGQEQPKPEQIAKGQEIVESLNETELLVDEEEKAQNDSEEEQVKGIPSFWLTALENLPIVCDTITDRDAEVLEYLQDIGLEYLTDGRPGFKLLFRFDSSANPFFTNDILCKTYFYQKELGYSGDFIYDHAEGCEISWKDNAHNVTVDLEMRKQRNKTTKQVRTIEKITPIESFFNFFDPPKIQNEDQDEELEEDLEERLALDYSIGEQLKDKLIPRAVDWFTGAALEFEFEEDEEEADEDEDEEEDDDHGLEDDDGESAEEQDDFAGRPEQAPECKQS
The following text describes a protein:
Function:
Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTPKPAGPPDGGWGWVVAAAAFVVNGLSYGLLRSLGLALPDLAEHFDRSAQDTAWVSALALAVQQAASPVGSALSTRWGARPVVMVGGVLTSLGFVFSAFARSLLHLYLGLGVLAGAGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDHFGWRGALLLLGAVTLHLTPCGALLRPLELPGDPPTPPRSPLAALGLDLFTRRVFLVFALGTALVAGGYFIPYVHLAPHALDRGLGGYGAALVVAVAAVGDAGARLLSGWLADQGWVPLPRLLAMFGALTGLGLLAVGLVPVVGSEEGWGGPLLAVAGAYGLSAGSYAPLVFGVLPGLVGIGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLVCGSFILSGSFVYMGLPRALPSCRPASRPATPPPERGELLPAPQVALLSPGGPRSTLDTTC
The following text describes a protein:
Function:
Component of the contractile F-actin ring; required for its construction following assembly of F-actin at the division site.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localized to the F-actin ring and spindle pole body during interphase and mitosis. Also found in septum.
Domain:
The IQ domains provide the interaction surface for the myosin light chain MLC1; The calponin homology (CH) domain binds to actin filaments.
Sequence:
MDVNVGLSRLQSQAGAPVGTKGSNTRLAAKQRETLQAYDYLCRVDEAKKWIEECLGTDLGPTSTFEQSLRNGVVLALLVQKFQPDKLIKIFYSNELQFRHSDNINKFLDFIHGIGLPEIFHFELTDIYEGKNLPKVIYCIHALSYFLSMQDLAPPLIKSDENLSFTDEDVSIIVRRLRQSNVILPNFKALSADFMLRASPVSSRTPSPTRFPKHARFQTLNSSDSASIYSSPYTSPTLEFSKKDASARSDILKMHRRTKSATPSLEQFNEPYKQTLPSHSIEFEDSFFQPPSQKGHMQRSFLTTFSAPTRRREALFSTTSGLSQRSPVDEKIVNAIQACGRGVLVRLRLVDMLQSLVEQSSSVVLLQAVIRGYISRNTYRIRKKAYDELVNWVTSIQSISRAYLIRAQYRKVVLQEEATKSIQTLQSIIRGGFYRRKYHSLIERLDLFTPSFVLIQSSALGFLTRHAIVNMLDNLYNYIPLFNRMQSILRANMFRNEWSNFLDSVQSFPVSFHSICKGRLIRDSINRLNGSLLGELDNFIKLQNLSRGFMIRRAFKEKLEKLKASTSSFIALQAIVRAFLLRKNLESIYDSFQKSHLSVIKAQSLYRGFITRTKIDYCNDYLLKRLPDIVFMQSAVRAILLRDDVNYTEVQLDSFIPEIVLLQSLIRGYLSRNKFSRKLQNFHKNMENPIVAKSIFRGRQEGLAYRELATAKNPPVMTVKNFVHLLDDTNFDFEEEVLLEKMRKEIVQQVRDNEEIEVHINELDVKIALLVKNKISLDDVLKHHNKYKFGKQSTEYLKINTLSMKSLNNSSRKFLELYQCFFYVLQTNEMYLANYFQALKTEGTSSVKIRHAVYLVLQIFGHGSNRREEVLLLRFISQVIKLEAALVNSSQDLLSDDCVWKLLFTGYRGDVREVKLWKTILGRIHKVLVADNHLDFEINPLTLFKSFNPEVASQTDSPKLTLSLAMQHPPTRNLYVSRLRELRKLCQSFLVALSKNIENIPYALCYTAAQLKNSLQRYFPAAHKEEIFGVIGKFVYWAYVAPVLVSPDNFKLVDGSITALQRKNLYTLSSILSEIFSIESCDSKQLGFFRPLSEFIEVSKQDTMLMLERLVDVVDPEVYFEFDAFEDLVNTKRPVIYMKRDDILGIYSSIAYVIDSIAPPDVNDPLRAVVNSLGPVSEQDNDFVQDETDVKLELNPKFCTIENPVAQERTLIVQTKRYILFIIRIQNGLNLLEILVKPVTDSDEAAWQNLLAEESEKNARNYDLFDDSIFSMSFAELKYTALSNIVEMEKLGFANRRNNYQDMVNSIALDIRNKSRRRMQRQRELDAGHQSLLNLREKRAFLDSQLKSYNEYIEQAMETLQSKKGKKKLIPFSKQYFHMRDLRKSGRVPRFGSFKYPALKLYDRGVLVSISHMPQKEKLYITISADEVGKFILEATSPTVKVSSPRCELHLDDLLSAQYNKVLTLDVLDGRLKLNTNMFLHLIFSKFYS
The following text describes a protein:
Function:
Acts as a receptor for the Gram-negative bacterium F.nucleatum.
Subcellular Localization:
Secreted.
Sequence:
MLLILLSVALLALSSAQSLNEDVSQEESPSVISGKPEGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNKPQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPPPAGKPQGPPPPPQGGRPHRPPQGQPPQ
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MTIDDQSHLKKEGENSTNPKINRYWIQRYDLFSRYDEGIQIDEEGWYSVTHEEIAIKHAERCRGKVVIDCFAGVGGNTIQFAKVSSSVIAIDIDPMKVQMAMNNANVYGVANHVDFVVGDFFSLAPSLKGDVSFLSPPWGGPNYCKVESFKMDMLQPRDGYSLFKIVQSITPNIIMYLPKNVDLAQLEELASLSSPPLTLEIEESCIGGKRRSKGRALLICLLSNHLSIVGYLASKGLTGSTAAVAVAVDESRINHRLCWTIPASSFGLCPSR
The following text describes a protein:
Function:
Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane. Nucleus envelope. Note=Translocates to intracellular membranes in a calcium-dependent way.
Domain:
The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic calcium. In the presence of phosphoinositides, regulates phospholipase A2 and lysophospholipase activities in a calcium-independent way.
Sequence:
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFIATTPDSRKRTRHFNNDINPVWNEAFEFILDPNQGNVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSSPDLRFSMALCDQEKAFRQQRKENIKENMRKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSHPDFPEKGPQEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMHTTLSSLKEKVSSAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSHNKGSTMEEELENITAKHIVSNDSSDSDDESQEPKGTEGEDAEREYQNDHQASWVHRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLRDFTQESFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPIIIHFVLANINFRKYKSPGVPRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAMVESIEYRRQNPSRCSVSLSNVEARRFFNKEFLSKPTA
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MMMQARTGLVNMLCICAEMAHGSQEQSLREELTCAICFDLFRKPVMLDCMHHFCQECIQSYWESCSGVATCPQCRREFPTRSFRPQYLVSGVVEKVRRCTSEEHRSKVQKHLEEALQSFQVDHEKLMRMKHGTEEKICGLLKTSGELKSKIRSAFERLHRILEEEEKTVLMELTRKERECLMRLERDSTQLAGRMLDLKKNMEHIQHQLDKLGSSLLLEVENVTVKPTTDVKALTTFRIEQFKDLYDGPLQYTFWRRMFKSISPAPASLVFDPETAHPNLILSKDLTAVTEKEMLQPVPRSSKRFLQSVNVLAKASFKSGRHYWEVWVGSKTKWDLGVAADSVDRAARVRLCPENGYWAIRLRDNAEYWAATTPWVRLRLRHSLKKVGVLLDCSTNKVAFYNAEDMSFLFAFHQARAHKFYPFFSTCFSDGKNEEPMRICHLNL
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSVPAMEWHMFHSPWQLDPCTSGHMCTILCVYIQVKILMKPNQMSYRRVQSLLEKKMNLQSVAQGPHFLQDPSLGESQHFELNCSVSEEKAKVPFPENIKRSFLEFIKKPSIRRLFAPAIIGAIVGLMIGIIPPFRKVLIGDRAPLHAVEDSADMVGKAAIPIITLILGANLLKGLKGSKVPLLVIIGIVAISLHFLQQTA
The following text describes a protein:
Function:
Required to maintain cellular respiration.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Product of the upstream open reading frame of this bicistronic gene. This may be the major product of the gene under normal conditions.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MADDKDSLPKLKDLAFLKNQLESLQRRVEDEVNSGVGQDGSLLSSPFLKGFLAGYVVAKLRASAVLGFAVGTCTGIYAAQAYAVPNVEKTLRDYLQLLRKGPD
The following text describes a protein:
Function:
Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity); (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives.
Subcellular Localization:
Secreted. Secreted, extracellular space. Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk.
Sequence:
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
The following text describes a protein:
Function:
Transcriptional regulator that forms a complex with somA to control biofilm formation.
Subcellular Localization:
Nucleus.
Sequence:
MPQHPGLPPGHPMAPGQHPNAHPGAGMVQAVHPGVSAPGGPQVTQGGPMMGMPPGAGTTGPGGPVQAHALSHLGPAQAHLFQQPQFAQTFANNPQLLQQHQHQQQILRQRMMFQQQQAAQQQQHAGLPVSLPNGTQGLNAAQLAAMQANSGMRPVNLQMHLQQMPHGPQNIQQQQQQLFAMQQAQQAQQAHQAQQAQQAQQAQQAAAAAAAAAAQPGQHTPQQRHAAHPQNMHDAQSVTPQPQPPPHQGSSTPQSNPPQPPSSQPQQQPGAAPQPHPTPNPPPQQLPQAQQPGQQPHQQPQQPPQQQPQQQQSQQGQPQGQQQQMTPQEAQMKAQQTQNQAAMMMQQRMGMKGTSILALLTFAEHLSNFTSRGEAQDLLYWQAFVDKFYSPVGVLRQGVYNPQAGSKQFEISTPALARYYLTQFTSGIRQIQMLVEGARERDSPNGGRIVESRRTSFIYWFTNESQLFTNGTLIAHFDHNNKIEMLDIVVMNHTEYLPRSQLQPLELSEQKQSPKVSKNLGKRAQQKQAQQAAPSLPESMVTANGVPTAVMSFLEVAETISHMQMLFQFSQQNPQFSPPEALRNLVNTLQSQNPNPGFMPSPMNPAMQQGQNLRGPQMNGPNQFASPAMAHLGLPPQGSPHLSAHPSPAQSHLAGPPGMVQQGQMQPNVGQATSASASPQVTNKRRRASTVKVENDDTGGPEVNGTATQGAAKVKASPRVGGKRQKGTA