lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MTLHLTSLLLSAILLGGVQSKRMCSFNDVLQNISLGSIPGPGVRPVKDWQTPTQVLVDMTLYTIVVLDTSSQTLISYIWLTLPINFPQPTPVSELTNIGTACVQTYGVDFVAKKLLLIVGSDEWYNDYISWEPEDFCEIRKIVTVGDTLWKPDLYIYEMTEPDDKEPVIPYYTIHYDGKITAAKPLRIISSCNIDIFKFPFDTQTCNLTFGSYVYSETDIIMLPKFYSADVNAHCLSVFVSKGDWNLLNVIVMNQSLISDGEAYSKVTYMITLKRAPIVYVINIIIPACFMVFLDIASIFIQMGSGERLGFKITVVLGFSVLLLILNDMVPNSDSPPILGIFCALCLAVMVTSIIGTVIINYMMTLSDTQPNVPNWIKTWILKHLACLLLFKLYKNEKDLVVSVDTDPNVKNTDNRPDMELKKKSKDSDKEIKVNLEVRLLKRLLAAVLKINQDLNLSKNGQDATSEWYLAAIVVDRLILILYLIIVIIIFSVVVIVWAK
The following text describes a protein:
Function:
Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYNFVSTVQKPTSVTHSVTGNFTGPNDKNLIISKCTKIEIFLMDQDGLKPMFDVNIYGRISVLKLFSVAGSKQDYLFISTESFKFCILAYDYEKKEIITKASGNAEDTIGRPTEAGQLGIIDPDGRIVALHLYEGLLKLITLDNNNTPNKINNNNNNNNNNNNNNNNNNNNNINNNNFNINNNNNNSPIQKNVNNVRLEELQVLDMTFLYGCKVPTIAVLFKDTKDEKHISTYEISSKDTELVVGPWSQSNVGVYSSLLVPVPLGGVLVVADNGITYLNGKVTRSVAVSYTKFLAFTRVDKDGSRFLFGDHFGRLSVLVLIHQQQKVMELKFEQLGRISIPSSISYLDSGVVYIGSSSGDSQLIRLNTEKDQTTDSYVTYLEAFTNIGPVVDFCVVDAEKQGQAQIVTCSGTYRDGSLRIIRNGIGIAEQASIELEGIKGIFPINNNNNNNNNNNNNNNNNNNNNSNGITDSKDRYLITSFIECTKVLSFQGEEIEETEFEGLESNCSTLYCGTIDKLNLLIQITNVSINLIDSNTFKRVSQWNVEPSRRINLVSTNQDQIVLSIDKSLLYFQINSSNKSIQLVKEIELPHEISCIDISPFDSFMDTKSQLVSVGLWNDITLRIFKLPTLEEIWKEPLGGEILPRSILMISFDSIDYIFCSLGDGHLFKFQFDFSSFKLFDKRKLTLGTQPIILKKFKLKNTINIFAISDRPTVIYSHNKKLFYSVVNLKDVTNVTSFNSDGFPNSMAIATTNSLTIGTIDEIQKLHIKTIPLNEEMGRRIVHLEDHSCYAVITVKNNEGLLGGAQDLCEEDEEVSYIRIYNDQTFELISSYKLDPYEMGWSITPCKFAGDDVNTYLAVGTSINTPIKSSGRVLLFSLSSSSSSNDKDSLDNNNNNNNNSGANGKLTLLEEIKFRSSVYFLLSFNGRLIAAVHKRLFSIRYTHSKEKNCKVISSESVHKGHTMILKLASRGHFILVGDMMKSMSLLVEQSDGSLEQIARNPQPIWIRSVAMINDDYFIGAEASNNFIVVKKNNDSTNELERELLDSVGHYHIGESINSMRHGSLVRLPDSDQPIIPTILYASVNGSIGVVASISEEDFIFFSKLQKGLNQVVRGVGGFSHETWRAFSNDHHTIDSKNFIDGDLIETFLDLKYESQLKAVADLGITPDDAFRRIESLMQYIR
The following text describes a protein:
Function:
Resistance to antibiotics containing the 2-deoxy-streptamine ring including dibekacin, gentamicin, kanamycin, sisomicin, tobramycin and neomycin, but not to amikacin or netilmicin. Acetylates a broad range of both 4,5- and 4,6-disubstituted aminoglycosides, including neomycin, paromomycin, ribostamycin, sisomicin, gentamicin, tobramycin and kanamycin, with no preference of one disubstitution over the other. Acetylates sisomicin and kanamycin most and least efficiently, respectively. Does not modify plazomicin.
Sequence:
MTDLNIPHTHAHLVDAFQALGIRAGQALMLHASVKAVGAVMGGPNVILQALMDALTPDGTLMMYAGWQDIPDFIDSLPDALKAVYLEQHPPFDPATARAVRENSVLAEFLRTWPCVHRSANPEASMVAVGRQAALLTANHALDYGYGVESPLAKLVAIEGYVLMLGAPLDTITLLHHAEYLAKMRHKNVVRYPCPILRDGRKVWVTVEDYDTGDPHDDYSFEQIARDYVAQGGGTRGKVGDADAYLFAAQDLTRFAVQWLESRFGDSASYG
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MSEPSSPTEQVVPVVKEKFHLDILNLSQTSQIQFGIRLQDYQKYRQYCSKRLDRIRGQLRKQYGKKQFINKVTDAKLINDSRYLVIALLKAERAWSYANDLKAAFEKKGDSRIAFHMSRRFSKAASNADQLLMICKEVADQYTIVEAEAYAAWMNSSNSIVKKYYQNALDEISASKQIYVELAKSGDHAQKDLYEKRIEESEPIIRFCLYNLKSKQEPEPSEEIEELLNQLKSSDSNNTSSDQELPMQLITWKSKTIKTDEKLREKLVIYSDYLKANQSKLPQTQSDIQTLDLTKNISQIFEVYDKLVYHLINCENIIKNELSALIRTNLKNKTVKSEIEESSQKILLSFVLYHKCKYLYERNTILIRMMQGVLEGEKVDESAIKKKANKVTYNDLVRLSTHQVKVFTILNDSKDDPTAAQKDVARDNDAQLILLKSQRLFFIGICLSNSHKYSETMSLFDRVLTNLANVKKTNTRNQLILSETSKLEESINQQRSQIHANSFIQQLSTNQDLKNQMSSMSLTSGTTGPTKSLINNLDSFETSFLQEKNLVDLPPQLEPVPVKPLFFDLAFNNVSFPTLDIGKSTPKKSSSTSTPSTPNTQDKSTPSKGLFSSFWGR
The following text describes a protein:
Function:
Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
Subcellular Localization:
Host nucleus.
Sequence:
MEAIAKRLDACQDQLLELYEENSIDIHKHIMHWKCIRLESVLLHKAKQMGLSHIGLQVVPPLTVSETKGHNAIEMQMHLESLAKTQYGVEPWTLQDTSYEMWLTPPKRCFKKQGNTVEVKFDGCEDNVMEYVVWTHIYLQDNDSWVKVTSSVDAKGIYYTCGQFKTYYVNFNKEAQKYGSTNHWEVCYGSTVICSPASVSSTVREVSIAEPTTYTPAQTTAPTVSACTTEDGVSAPPRKRARGPSTNNTLCVANIRSVDSTINNIVTDNYNKHQRRNNCHSAATPIVQLQGDSNCLKCFRYRLNDKYRHLFELASSTWHWASPEAPHKNAIVTLTYSSEEQRQQFLNSVKIPPTIRHKVGFMSLHLL
The following text describes a protein:
Function:
May be a carrier that transport small solutes by using chemiosmotic ion gradients.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Note=Sorting to lysosomes involves tyrosine- and/or dileucine-based motifs.
Sequence:
MPLEESGENTPLLRGEIISDGDTDRSRWRSIRVMYFTMFLSSVGFTIVITSIWPYLKKIDESADASFLGWVVAAYSLGQMVASPFFGLWSNHRPRREPLVCSIFINVSANIYYSYVYLPPSHNQIHMLLARTFVGIGAGNVAVVRSYVAGATSLKERTSAMANMSACQALGFILGPALQAVLSFIGETGVSVDVIKLQVNMYTAPALLAACFGVINILLVILVLREHSVDDHGNRIRPINYTPEERVDVPPEVEGDIDHIAVFTSNVLFFIILFIFAVFETISTPLSMDMFAWTRKEAVLYNGIILAAIGFESILVFLVVKVVSARVGDRPLLLGGLILIFVGFFMLLPWGNQYPKIQWTDINNNTIPPIQLAPTPASNSSLEPIGCPSEQTWCLFTPVIHLAQYITSDILIGVGYPTCNVMSYTLYSKILGPKPQGVYMGWLTASGSGARTLGPVFVSHFYTILGPRWAFSAICGIVLAAIVMLSAMYKRLVAFSIRHGRIAE
The following text describes a protein:
Function:
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain; Involved in production of the polyketide antibiotic thailandamide.
Sequence:
MNSPERDLSERLAKLSPEQRAALRKRLARSSSSTSAPATQRADSGQSKAAVEPIAIVGVSCRFPGAPDLDAYWKVISEGIDATAEIPPERWDVDSLYDPTGQKAGRMSVRRAGMVDNIDQFDPKFFGISPREAARMDPQQRLLLEVSWEAFEIAGIPVTSLAGTPVGAYVGIGGTDYSKVPSTYDGYYQYIDAHVGTGNALSIAANRLSYIMDLRGPSMAIDTACSSSTMAIHLAVQSLRAGECDAALAGGVNAILTPETTIAFSKARMLSPDGQCRPFDADANGYVRGEGCGMLLLKRLSDAERDGDRIWGTILASATNQDGRTSGITAPNGVSQQAVIRTALGEAGLPASRVNYIEAHGTGTPLGDPIEVDALTQVFSGKPGVDPPCYVTSVKANVGHMETVSGVAGIIKLLLMMRHQTIPGQLHLNKLNPRMSLKRSRIVIPAQSPPWPVDDEPLVAGVSSFGFGGANTHLVMQQYLAKQTVEPSASKQSDTKDRTQHVLSLSGKSDAAIAEVASRLIQHLDRTNDHMADVAHTMNVGRVHHTHRTAVVFEDAKQLHRQLTQLSEGKKGPGIRSGQTVTSRATRTAFLFTGQGSQAPGMGRGLFETQPVFRKSMKRCDELLAKVLPKRLLDVLYGEGSDIELVHQTRYTQPALFAIEYSLAQLWLSWGVKPNVVLGHSVGEFAAACVAGVVSLEDALSLIAHRGRLMGELPAGGGMTAMFESAEVITDRLGEFESSVSGSLSIAAENGPQNTVVSGPQSDLDAFAKHCDEAGIASKALQVSHAFHSQLMEPMLDEFRQIAAQCEFKSPRIPLISNLTGEQWTKAWDADYLCDHIRNAVRFEPSMRALAEMDIDVMLEVGPSPILSGMGKRCLPESSATWATSLRSGKDDETTLFEAVGDVHARGGKIDWKAFDQPWKRQRLVLPTYPFDRQRYWLDPSDEIVEDPSRNRTGTGELLHPMLGRFQPSALRSRLYENALSARSPEFLADHAVQGSVNLPGAAFVEVAFAAARDRFGPGKHAVTDANIEQAMFVSEDRWKTFQTIVDESLSLEVYSRDRVDANDSWQRHMSASLVPAEQVGDSVDVEVVPPPPGLATVAQRFVGGKDHDEFYDLMSHRRLEYGPRFRMLHRIDYSIDEALGQVQCDDATCAELDDYILHPVLGDALMQTFSALVPRPDHDTFSEATYMPTKVSRAVVYQRPEGTLRTYGRRSSSGDVLDPEFVEGDVWLVNERDEVVAEWTGVRVTRVGRVGGGKSESLDDSLYQIDWQATESLPAASDLEGKQVWLLGDPGSRRDSLAKQLIGFGAEVVEGDLDEDLKTLAEKSESTLPLAALITLWDPSGKSSNPADDAVAVCQSALKQIRSAITHVPVSKHFRGWWHVTTGTQPVSESESSIDLVHAPLWGMIRVAMMELADLKPSLLETDPSASDQSNGLVIAAEVIAADDEDHVAYRDGTRHLGRLVKRRAPAESGNDTSVTIPSQPHRLRFRQTGSFDSLYFEPMERETPQGSEVELRVNAAGLNFSDVLKVMGLYPGITDKVVPLGIECSGVVTAVGKDAKRFQVGDQVMGVAPFSFGSHAKTPEYTLVKRPAGMDDVEAATIPIAFLTAWYGLVHLADVQPGERVLIHAGAGGVGLAATQIAQYLGAEIIATAGSDEKREFLRECGVKHVFNSRTTEFADDIRRAFSGEGVDVVLNSLPGEAIPKSLGVLNAYGRFLEIGKTDIYQDRKVGLLPFQDNLSYHAIDLDRVLRQRPAKIEKLWAELAERFEAGDLQPIACTEFDQTEMVETFRYMAQRKNIGKVITRMSTIATTDAVPQEEASESTVLITGGTGAIGLKLAKHLIKDGATSIALLSRRQPVGDVAAKIDALKQDADSVQVTVLQGDVGELDSLRSALKQLPGSLPPIRHVYHAAGVLQDGLLMDMTEEQLRVPMGSKIQGGWNLHVATKDLPIETFVLFSSIAACLGSPGQANYAAANGFLDALSEYRREKGLPATSIAWGPWAESGMAATEDRSSQLESRGMRLLPAIACLQTMQQLIDAGDQYVAVMDVDWPAMTKSMRRSRPFFAEFADRSQVDGKASVDQVDHEFRAQLSEVPESERTERLRRYFASELARLMGWEAEQIDVKQKLSELGMDSLIAMELKNNLEQRLAITIPMSALVESPSINSLVGHVVSQFADEDGEMKKASEKSEEPGGDRTALIVPLKADGARSPWLCIHPLGGSTACYSEFSQQVDDDQPVYALVGGGSDGVSEPPTSLDAMMEEYVELVQAQFGDDELRLIGWSAGGVFALELARRLENEGRSNVAVTLLDTPLPSIYRNVDPNDDVQFVADLVQFSNAFSGTDMYLSAEELEDARGTDQIWQRVLEEAQRAGVLSQSASPDMVRKLIDTSRQHVLFIKSYEIDPTSPSVQLILPVKTTALEGSSGERWTDHLDWASHLDSEVIVEQTDGDHFTMLLGEQAKELAKRMEQHAAAK
The following text describes a protein:
Function:
Serine protease involved in intramembrane proteolysis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSTLKKFSIKGATTRIRDGVGLYFGLNEEQIQQQQQQQQQQQQQNSDNNQADNNNSSNSNNNNSYYEEDEPYWMKDDFWEKAPRYNRGNDIEMDRYESPPVYSPPQNNQNKGNGATLNSTDYYPSDVVTPSGETVASGGGGGGGGNPYLVGGDDMNDKMMMGGEGDDDDDGATRRGRGRGRGRGRGRPGPNNQGGGGGGGRTDGKKPFRPSTLGRGVSSLSLKEDHRDMEPPKQFVPYFIIAISLIDLVMFIWEIIYNGGFEPWKTNPWFGPNSYTLLDVGAKYSPLILNGEWWRFFTPIFLHVGIFHYLMNMVTQLRVGMQLERAYGGHRIVPIYLLCGVAGNLCSAIMLPNSVQVGASGAIFGFLGVLLTDLIRNWSVLAKPWLNFGSLLFSIITSFAVGLFLPGVDNFAHLGGFIAGILTAAIFLPSLTPKRAIGKRLLLLMIVIPLTVALFVALFVVFYKNIDADEWCFGCKYITCLQVLSWCKT
The following text describes a protein:
Function:
Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane.
Sequence:
MPPGGWRWLRGLWAAGQPLFQGRALLVTNTLGCGVLMAAGDGARQTWEIRARPGQKFDPRRSVSMFAVGCSMGPFLHYWYLWLDRLFPASGFPGLPNVLKKVLIDQLVASPMLGVWYFLGLGCLEGQTLDKSCQELRDKFWEFYKADWCVWPAAQLVNFLFVPPQFRVTYINGLTLGWDTYLSYLKYRIPGPLTPPGCVALGTIQTEPPDARQQGKTD
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAASASEKGNKKKTEKKLAAREEAKLLASFMGVMNAMRKQKTLCDVILMVQERKIPAHRVVLASASHFFNLMFTTNMIESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPYMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLSSCEVYDPATETWTELCPMLEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKINEWKMVSPMPWKGVTVKCAAVGSIIYVLAGFQGVGRLGHILEYNTETDKWIANAKVRAFPVTSCLICVVDTCGANEETLEI
The following text describes a protein:
Function:
Cell wall acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source. Plays a role in dimorphic conversion and virulence.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MAANSSFFLADNCAPHNQSFIQFCIHAASKKKGRIALMCLANLFLLFSFHLLYARFCSGFPYVVPSTARSTNQIFHTNLEQLVNSPENKQIFSQLKFSDQAFYDPHDNVVGTTEFPVFNQYQRQPYVANGYIGSRIPNLGQGFTYDQLTNSSTANDDDLLNGWPLFNKRYSGAFVAGFYDLQKNTTGTNFAELLENGYESVIAAVPQWTALSLSVEILGKKYTLDPSLEHEAIGDITNYVQNMSLSDGIVTTQFTWLNTFDVKYEILAHRENINLGLVNMQVYNPGNESVQVIVSDVLDFNSSQRCQLNQISHDKNGIYVTFHPQGLSYIDGAIYSTLSANGQITREQTNETVFQNVELTIEPHSCVQVAKYVGIATTDLDPDSFKTADDVLKFARKVSQNKKHGDATQLVNSHRSAWSKIIQDAPLVTFPSDSLLNLGARASIFHLLANTRPNAEGVTGALGVSGLSSDSYGGMVFWDTDLWMLNGILPFAPDHIKSFINYRVHLHQQAIDNVPRGYQGAVYPWTSGRFGNCTGTGPCLDYEYHINMAVAMASWQLYISGAADDTFLESVAYPIINDAASFLAEYVVHYNDTLGKYTTKNLTDPDEFANHVDNGAYTNTGIVLVMRWAQIAGSILGKQVPKIYHDIETAMFLPTAENTQNITLEYSGMNSSVGIKQADVIMMTYPLENELIDQDQAYINMEFYSMKQVGYGPAMTFPIFSIVASNLAFTGCASQSYLHKAIQPFLRGPFAQFAEQNNDDYLTNGGTHPAFPFLTAHGGFLQAILQGLTGMRFDYTFENNKLQRLLKLDPIALPCLGEGVRFDSIKYDNHTLSMAINETHFTIKNKGKTTPNARNYVTILLAERNAMHGKYTINDEDEQSFPLFETSESFPDSISECNKAGFFNITEGAYGDVSISINDGDNTTSWQAKYNDTTGKVLVDLKSFRNISSGTFIWGDKPPKRVKVSKYSGSSFTAVTDFFAQVDFGNELFNEYKYANPEGKLHNQSDVFEEVYSGDVKISAPFDPEEYFQVWVPTRHNITEVAVNLQTRFLLIEVDEIHNTEAIDGDYGGAKLAEVVFY
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in sucrose transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNTCIYFTIQVLENLQKNTLFIPNKLQTSLVSFTIYLSNQTCFDKYKENQMGKFEQEAKDLLQAIGGKENVTAVTHCATRMRFVLGDDKKANVKAIESIPAVKGTFTNAGQFQVIIGNDVPIFYNDFTAVSGIEGVSKEAAKSAAKSNQNVVQGVMTTLAEIFTPIIPALIVGGLILGFRNVLEGVHWSMLDGKTITESSQFWAGVNHFLWLPGEAIFQFLPVGITWSVSRKMGTSQILGIVLGICLVSPQLLNAYAVASTPAADIAANWVWNFGYFTVNRIGYQAQVIPALLAGLSLSYLEIFWRKHIPEVISMIFVPFLSLIPALILAHTVLGPIGWTIGQGLSSVVLAGLTGPVKWLFGAIFGALYAPFVITGLHHMTNAIDTQLIADAGGTALWPMIALSNIAQGSAVFAYYFMHRHDEREAQVSLPATISAYLGVTEPALFGVNVKYIYPFVAGMTGSALAGMLSVIFNVTAASIGIGGLPGILSIQPQYMLPFAGTMLVAIVVPMLLTFFFRKAGLFTKTEGDTNLQAEFVAQEEAEFVSHELVELTSVEIISPLTGQVKELSQATDPVFASGVMGQGLVIEPSQGELTSPVNGTVTVLFPTKHAIGIVSDEGVELLIHIGMDTVGLDGKGFESLVVQGDHVTVGQQLIRFDMDVIKAAGLVTETPVIITNQDAYTATITGTYPTTIQAGASLMVATRI
The following text describes a protein:
Function:
Associated with the mammalian reproductive process. Plays an important role in the formation of the seminal coagulum through the cross-linking of specific proteins present in the seminal plasma. Transglutaminase is also required to stabilize the copulatory plug.
Subcellular Localization:
Secreted. Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MDSRNMLVVYSVNLEKKLNAAAHHTIEYQTQKLVLRRGQIFSLKVMLNRPLQSHDELKLIFNTGHNMPFYTVELDPMTSYRSKGWQVKIAKQSGVEVVLNVISAADAVVGRYTMNVNEFDAGVFFLLFNPWCSDDSVFMASEEDRAEYVLNDTGYMYMGFAKQIKEKPWTFGQFEKYILNCCFRLLTHLEPKEMQSPVLVSRAICTMMCAANNFGVLVGNWTGDYSNGTAPYVWASSVPILQQHYITRMPVRFGQCWVFSGVLTTALRAVGIPARSVTNFESAHDTEKNLRVDIYLDESGKTIPHLTKDSVWNFHMWTDAWMKRQDLPQGHDGWQVLDSTPQEISEGQFRIGPSPVSAIRQGLVQIMYDTTFVFTEVNGDKYIWLVKQNQEREKNVLIAVETASIGKNISTKMVGENRRQDITLHYKFPEGSPEERKAMEKASGKRPDDKLNSRTLHISVLQNSVELGHPINLTIVLKRKTATPQNVNISCSLDLQTYTGNKKTNLGVIQKTVQIQGQESEVSLSMDSSFYIYKLGMVDDEMVIKGFIIAEIVDSGERVATDTTLCFLYSAFSVEMPSTSKVNQPLTITCNFKNTLPIPLTNIKFSVESLGLNNMKSWEQETVPPGKTINFQIECTPVKTGPRKFIVKFISRQVKEVHAEKVVLITK
The following text describes a protein:
Function:
May play a role in regulating cell adhesion/migration complexes in migrating cells.
Subcellular Localization:
Cytoplasm. Golgi apparatus. Cell projection, lamellipodium. Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTTLPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLLSHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKNTDLSLEDSPMCVVCSHHSQISPILENPFSSIFPKCFFSGSTPINSKKHIQRDYYNTLLQTGDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSEPEEPENQTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPVTSGEQKPIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELGLGEEFTIQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSSKFAAAEITEGEAEGWEEEGELNWEDNNW
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAGAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKEPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK
The following text describes a protein:
Function:
Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process.
Sequence:
MLSRKRKHGSPDAESNPSKKQITSLRSSPRRTTRQKENIPISLNSPQKIPSTPKKTQRAFLLESPPKRVSPRKAVLGAGTFYSKQKPLYLTPLERKVLKEAKSPPSVTNKEPSRPPLTAANQVVKPAKKVQKKPRASAPQSNLKGYFTAKPKATKSSSDKQTDQVLKSTMAPISFSSMKSKGKPKLVVGAAFFNTGKKPTSMYKKSAQNTKPKPTYEKPSIRKPVREKELVTAPGQRSPVRRAVFLKKQPEVEVSHDKRESTQAPMSPQVLADVHGITKELRVVLRRSVSPETGSQDAPSEADSVFDVSDLLLPDHDSSHDEEESSVYPIFGTKRPQKKGKLSPPLNSSTPSALTATPALKAKERSMLRREMKKQTDNQLIIDAGQKQFGATTCASCGMLYSTDSPEDNFQHTQFHQRFLDTIKFVGWKKERVVAEFWDGKIILVLPDDPKYATRKAEDVRRIADSELGFQQITLSSPSSAKTYLFINTDRMVVGCLVAENIRQAYRVLEQQEKQKDMSKEDFMEHHRTWCCSTVPEKALCGVSRIWVFSLMRRKSVATRLLDTARNTFMYGSHLTKEEIAFSDPTPQGKLFATKYCQTPTFLVYNFIS
The following text describes a protein:
Function:
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Nucleus.
Sequence:
MAEVHVIGQIMGATGFSESSLFCKWGVHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHLQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLDCPTWRPLGSWREQLARAFVGGGPQLLHGDAIYSGADRYRLHTTSGGTVHLELSLLLRHFDRYGVEC
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MATELRLHSPAGVEPAVYVWPLQHTDKIDGAVEIVDTIRWVCEDIPQLMLAMENNVLNDYDTSSYESMLTLCDKYNRTIDAIRQLWKVSSCDSPISKRATPGLLKHIMQQTYAHAIDDPDKLNCYEPFSPEVYGETSYDLVAQMLEHVKINEDDVFIDLGSGVGNVVLQVAAATSCKLAYGIEKADVPAHYSEGMQKEYKRWMKWYGKEHSFFLLDHGDFLSDTMKEKIASSNIIFVNNFAFGPRVDHQLKERFANMKEGAKIVSSKAFCPLNFRITDRNLSDIGSIMDVVELSPLRGSVSWTGKPVSYFLHTIDRTLLEKYFQTLKDPKLREEYYKSCVRAKRPRRSNIDYLASRSLDLGKTSSDSDSAVYGPTTRRQWSEWIANRDGMKENYDEMMEDSEKMDPDSDVSSQASRRKRRRNKDSSETETPMPPPPKPAKQKTIKIPKKEEKKDSSLRGRGRPKKADNVMSRRARDELKKSAALGMDLLHQHTVSLSQSPPDKSNGMLNNLGMSFNLASMVTPVKEKSRPKSRERKPSHRQKKDLEASIQWLVDDYKMQLLQFLSYMKTPPYTDLVRKQLEEEKLYNEQLNLKRGLLEDQISMLSKEGVRLLNQQLDKLGIQAKSPSELVAKSREIVGKHRELQERYQSLTTNMQLLEADNRKLVETRNQEVVTQLLGHSGKWDNSDSASNAKAASLITEQIIQEFSNQQELKRQVQKLEFEVTTLEKIGETTKKPEKAAKKKRRNKGSEKSRKIKDIVGPPVSPPAIKEDTLKHERLSGSYSSSPVHSKSWLGEGTPGTHKSPRAFQGGPGEGEHSYMSPGKVALQRKLSNSMESSPMALRDDKGKEFASDVGQLMLNAHKQMQQTQKGYSGKVEPVHSSALHVVTSSVAGGLQEGPMMHTSMASLGSRDGVPTATSSAGVHHLLQSCMISPLEMKHSGLYRFMPAAQVSKVLNSSLDTSEPPLSPQNVTLYPPASGHPPDPRQDLTASSKVDTPTLSSLAMSHPTLGRNVTDADSGRSSDASSSKEELTKISSASEAANTPTSTSSKKTESNKAKKSRKRPVPTSAAEQNIPSKVAVTEKCNQPSQVGGAMTETQDIITMVTNVNQPLKISAIPSPEGAIAGQTGRESVPISQAENSGEKSNTNSDPETSNVRESPNTKKLQANISSKIDALAAFASSQLDRSKQIRRQSAGNSPGDIHGSWDTHNPSQMPAGSRYMPTLHESQAGVRPAAAGPHDLLSAQLSNAGLACATSIHGMTPAAPNPWQMAYMNKIQGSDEAGANSGKREQKEKKSEAKSANEPTMFVSGHYTPKGKKPIPVKLSPKPLEQDPSGDELVPPKTPGKDFEEENIFSSSSLKQGSTVSNSSSSSSTSTKTEVMTVVAKRNTVPPQEDTSYTDVQFHKKFSRKGNRWNCKPSSSLNVPGQEAQSKKHSAVGSSTQKKEGEGQKGKTQSPVPTVVLQRPPVHDPPKLAIKQQHSSHYHSKGSSSTTSSSAVSSQQGTKYSSSSNHGKHDPNLGPFIELRSAGLKQVPNPPPGGAPITTQQTLLTTSAGTQRFTGGTYYTSALASSGIHPQADLLDRSQNRGSGGSQSHSSLQSSTESYRSPFSTPPPPPSSRGTPSSSDSTHSDSHGSMRATPPSHGARSLPPTMSPLPSSVPLPGGYAMNGVMPQYAVNQQTGDLGMPTYLPNTGNYMPVTHSGHGPSYLMQYGTPR
The following text describes a protein:
Function:
Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence.
Domain:
NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d- amino acid conversion) are present within the NRP synthetase. NRPS9 has the following architecture: C-A-T-C.
Sequence:
MPRSTPVASEQVDFVMKLLGNTTKQITTATYIKLAWAVVISCNTGSNDTVFGITVNGRGAPIDGAGEMTGATIATIPQHGCILRVWSLPRMPAGMISRERVQRLLQHLELVLQDLMADPSCKVGDLPRMSRQEWDQIQRWSGTLPPVSRQCVHEIVNQRSLQFPNACAVSAPDGDLSYAELIRSANAVAAELLVHGVERGNYIPVLFEKCKWSPVAMLGVLKAGAAFVLLDSSYPPQRLHTICGGLKTQIILCSKDMYARAASLGPTAIAIHENAAFLADIPDVTFPVVSPENAAYVVFTSGSTGTPKGAVIDHQSYCSGALAHNRAHVLGRNSRVLQYASYAFDVSIMETLSTLMAGGCVCILSDLERHDHFANSVQRLAVTHAFLTPSTARLLMQRELPSLCVLVLGGEAMSLADRSYWMSRVRLMNEYGIAECSVASTIREVSHVEQKDIGFPMGVVAWVVDQNDHEKLVAIGATGELLLEGPSPPVGRSSSNRAGSGRCAMGSQAGSYKTGDLVRYNEDGSLSFISRKDSQIKIRGQRFELEEVEQHLRRIDEIQEATTVVAAPSDRPKQPYLVAFIVPRARESFCVCSARALIPHPTEEFRLQAATIQTKLHSILPAHMVPAIYLPVNRMPKTSSDKIDRCRLKEEVGKWSWSDLRAYSVSSMSHRAPSNRVEQDLQRVWEQILGILLDSVGVEDSFFHLGGDSIIAMQVVAEARSRGLDHSVQDINQLKTIKAIANKIGDVQRAAIKLVQNHAMLRARYVRQKDGAWKQFFTGYTEQCFRFSVHQVKSAQEMRQIIGESQTSLNPEHGPVFTVDLFHHGGEQSLLMIGHHLVLDLVSWRIILADMEAMILDPQHQPHLTMSFQTWAHLQAEYGTRHLEPPPGQQPCSIDEPSMRQFWGAENNANTGGDSKTRLIRMNDDLTRKLFGPSSQALDVEPVELLHAAILFSFVNTFPQRPALVIFGEAHGRETWDSSVDVTRTIGWFTTLWPVVAQVNPSDSLETVARTVRQARRAMDMHGWTHFTSVYHNTRQTKRSAGAHLMEITFNYAGKFQQVEQDGSLFRMEPMAKQNLFDGAAELGRWAMLEINSVILNGLLEFHVPYNRGTDEARVLTPWMDNLVKCLEGLASGFA
The following text describes a protein:
Function:
Regulator of mitophagy.
Sequence:
MFRKLGSSGSLWKPKNPHSLEYLKYLQGVLTKNEKVTENNKKILVEALRAIAEILIWGDQNDASVFDFFLERQMLLYFLKIMEQGNTPLNVQLLQTLNILFENIRHETSLYFLLSNNHVNSIISHKFDLQNDEIMAYYISFLKTLSFKLNPATIHFFFNETTEEFPLLVEVLKLYNWNESMVRIAVRNILLNIVRVQDDSMIIFAIKHTKEYLSELIDSLVGLSLEMDTFVRSAENVLANRERLRGKVDDLIDLIHYIGELLDVEAVAESLSILVTTRYLSPLLLSSISPRRDNHSLLLTPISALFFFSEFLLIVRHHETIYTFLSSFLFDTQNTLTTHWIRHNEKYCLEPITLSSPTGEYVNEDHVFFDFLLEAFDSSQADDSKAFYGLMLIYSMFQNNADVGELLSAANFPVLKESTTTSLAQQNLARLRIASTSSISKRTRAITEIGVEATEEDEIFHDVPEEQTLEDLVDDVLVDTENSAISDPEPKNVESESRSRFQSAVDELPPPSTSGCDGRLFDALSSIIKAVGTDDNRIRPITLELACLVIRQILMTVDDEKVHTSLTKLCFEVRLKLLSSIGQYVNGENLFLEWFEDEYAEFEVNHVNFDIIGHEMLLPPAATPLSNLLLHKRLPSGFEERIRTQIVFYLHIRKLERDLTGEGDTELPVRVLNSDQEPVAIGDCINLHNSDLLSCTVVPQQLCSLGKPGDRLARFLVTDRLQLILVEPDSRKAGWAIVRFVGLLQDTTINGDSTDSKVLHVVVEGQPSRIKKRHPVLTAKFIFDDHIRCMAAKQRLTKGRQTARGLKLQAICSALGVPRIDPATMTSSPRMNPFRIVKGCAPGSVRKTVSTSSSSSQGRPGHYSANLRSASRNAGMIPDDPTQPSSSSERRS