lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (By similarity). Involved in neuronal development. In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Postsynaptic density. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=At steady state, may be preferentially cytosolic.
Domain:
The PH domain mediates interaction with lipid membranes that contain phosphatidylinositol-4,5-bisphosphate, but does not bind membranes that lack phosphatidylinositol-4,5-bisphosphate.
Sequence:
MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFQPPQPPVLCS
The following text describes a protein:
Function:
Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
Subcellular Localization:
Chromosome. Nucleus.
Domain:
The SWIRM domain may act as an anchor site for a histone tail.
Sequence:
MLSGKKAAAAAAAAAAAAAAAGAEAGSGAAGGAENGSEVAAPPAGLSGPAEGGPGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Sequence:
MGVLNLLNAKIIISRSVSPYLNLALEDFLFKNSTAKQCLLFYSNLPSVIIGRNQNPWTELNVRQCRKDWVNIVRRQSGGGTVFHDLGNVNYSVIMDRQNFSHTRNAQIMAKALQRSNIDASVNNRHDIVLSSTGEKLSGSAYKIARSRCYHHGTMLLNTDLLNISKYLRSYTTGIRSSGVKSVRSPVVNVNVPVSKFVYDAIHTYLETYHLEKVPQITSITAEDIMGIEDIAKMEEQLRSWNWTFGQTPKFQQTLKEEKLFQHPLTVNISVLHGRIDNAQFVTEDKKLSDELSTYDWNGLRYDSGSVNQILLQHTPSEDVRAVVSWLARTI
The following text describes a protein:
Function:
Catalyzes the formation of O-acetylserine (OAS) from L-serine and acetyl-CoA. To a lesser extent, is also able to use succinyl-CoA and propionyl-CoA as acyl donors, but not butyryl-CoA. Does not acylate D-serine and L-homoserine.
Miscellaneous:
MISCELLANEOUS: Is able to complement an E.coli cysE mutant strain but not an E.coli metA mutant.
Sequence:
MEKSPLKIGILNVMHDKADTKTRLQHVLTHTAIPVDLHFYYPMTHYAGRTVPEAVSSILDPLDIHEVATMDGFIITGSPIETLEFDQVHYIAEVRTLLKTLSQHVPNQLYLCWGGMVALNYFFGISKLILPHKLFGVYPQTILEPHPLLKGLKNDFKSPHARYAEMDVRGIHADPRLTINATTTKGKLFMVTEPTDTQTFVFSHIEYDRWGLDSEYKREVAAHPEIDYVRAKHYYHHKNDYDHPKFNWKKTQRTIFDNWIQHVADHRNDNH
The following text describes a protein:
Function:
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MPSRCVAAGCSNTSSESVSVYKFPKQETLLKQWTKQVQRMRANWVPTASSTLCSEHFEPCCLPFVTSQTGRRELGGMREAGGRPRCLYRVFRYLFFFEKY
The following text describes a protein:
Function:
May act in meiotic drive.
Subcellular Localization:
Spore membrane; Multi-pass membrane protein.
Sequence:
MSNNYTSLSSSLDEEMGLKAGHEIDLEGSPPSEHNSEEKSTLPSNSDILTSANPVSQASETPDHSIESNTGSTQSPTSHSLLLKFSFCIVYYFYFAIVVLGCVLPFEHTHTFLIAFLVIFGIISVILFSGSIYYYETWTKTVKHFLKKVISPFKKEYIVCAFLKTFVFYGLLKTIEHFLVLLSGDKWGWKCSTLSSILTPVSCISFCLNESVQLRSCSTHLFINTVAWIKSLGGGKNAFENNYNQLNETSPEDLV
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system, functioning in plasmid maintainence. Responsible for the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Half-life of over 2 hours. Cell killing by CcdB is accompanied by filamentation, defects in chromosome and plasmid segregation, defects in cell division, formation of anucleate cells, decreased DNA synthesis and plasmid loss. Interferes with the activity of DNA gyrase, inducing it to form a covalent GyrA-DNA complex that cannot be resolved, thus promoting breakage of plasmid and chromosomal DNA. DNA breakage requires hydrolyzable ATP. Toxicity is inhibited by labile antitoxin CcdA, which blocks the activity of CcdB; CcdA also removes bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Also acts to inhibit partitioning of the chromosomal DNA. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdA.
Sequence:
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEVADLSHRENDIKNAINLMFWGI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSDIKVTLAVEDRAENQDTLSISEIVPRIVAERKSFVDVTEESLLEEIANCVADSADDNVKDEVDEKPDESPFDQHRLKLLENVKAAYNESALALDFVSLLISSVRPTSASTSMSPHLKTHIPVGSLGADRVPAPQVANEPGVGIGWKIESLTNARDRLKTCASRLRTEAAKEKTYWAGVASIAATGEVLFKVRNSDTRGLGIKYGFGDAGSKYRDPGIGVLKRSATGTVDFEPKEEVQKKFVRVTIKSEEGEVTKSVSNVYTRDSKPPTDPTLAAIHETRHALFEEELFFEIAREARLLTSRKVTVADGAVTVDLGEGDMVVIEWVEVPEEPTTTFAPSLANLFVLALRLLLANAHRQQLEKMRTPPAPLQSKGGPNPNPPLPILRPLLAHILHKRLVSRARRSLYLLSTTHSGLSFEITTNNSTDKESSSLGRLMAAPVSNLKIKFSDKGNAKVVIPSPLQSHQSMFDVTMFKGTSQETVTSHTGFHELVELEEWVRWAADRSEPKKSN
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Subcellular Localization:
Mitochondrion.
Sequence:
MIIFRKFCYRFAQAIQESQQQISKYSNPDSIPTKMVLKNITLSEQLSIQQLSILTDIDQKELIRTINQFSKQPVNYTKITKDLIEPILPLYNLSSYKENPITRPPIITIMGHVDHGKTTLLDRLRNSNIAEGEVGGITQKIGAFHVKVGDNQITFIDTPGHEAFSNMRQRGAEFTDMIILVVSAADGVQPQTKEVIQIASQLNIPIIVAINKIDVPNVNPEDVELELLECGLDLESQGGNIPVVHISAKNGKNIDLLLELIQFQGELLELKADPTVPAQGVVLEARQSELTEERGSTIIVQKGSLKINDIIVVGNQYGKVRVMRDDRANTMQIAGPSSAIEIIGLKEIPQSGSKFFVAKNELIAQLIVNKRKKEAEFKQLQNAEMIDGSFGKIKFQNKHEKRDVYGDTKHLIEKYKEIQNMLREEIESTEDPEIKEALVEKLRQHELFSSQMINLAPDTQVLKLVIKGQDFGTLETLIKLVNQLKEKENAEILILSSGVGDVTQKDFKDAQLFGATIVTLNSNVPNDIIRQAQQDKIDIVQHQIIYHLIDDLKTLVTAPRNAKVSIIGTAKVQNVFDVKLKGQSRKIYGLTVTHGILNKKCRVRLLRGGKVVAADLEIANLKHFKEEVDRIESGKDCGLSIISNVEVKVGDEFECYKS
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MDIAELGERGLIARLGRFFGQAPHILVPGGDDAAVVAPGSGALVATTDLLFEDVHFGDRTTGPFDVGWRSAAANLSDLAAMGAAPFGMLVGLGLSPGTSVEWVEAFYEGFTACSAPVGALLLGGDTCRAKSRTVAVTALGTVDPRRILRRNAARPGDALVVTGHLGASRAGLAVLLEAERYAHLGSPVREAVVAAHRRPKPRLEVPPLVFALSGRAAAMDTSDGLTDAIAQVCAQSGCGAVVDLAVLPIDAATAQVAGKQAIAWALGGGEDYELLIALEPGAAVQLVERLAAIGIGGAIVGRAVAGDRVVDTEDRPLAAPGFEHFNRP
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(3) position of uridine 2843 (m3U2843) in 25S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes predominantly to the cytoplasm, with minor localizations in the nucleus. Associates with pre-60S ribosomal particles.
Sequence:
MLLMRRFAFLTSSVYFKYIPIYSQYHYSSQFPINMNPKKVAQLPVHNKSTLPPQEIIDLFKITFLEELYPKDQDNEKSPLTEQIQAVKSDLYNRDYNAAFNNDSKRIAYCCRWSPSRATSYASVFAHFPELLKIIRCEIDDKDSNVLCIGGGAGGELVALASIFTLSRDFSSKFASALKIDNEVNKKPRNLNIQLVDIADWSTVVEKLTATIKSKWLYGDSEAESFNVNFTHKDCLQMTEPQDIKIYQGLDLITLLFTTNELFTQKKVESIKFLQRLNENCAPGCHLLILESAGSYSHITINNKKFPIQFLIDTILVGNRKDKGTTGPWSLVSENDSIWYRMDPKLDYSIPLENMRFFYRLYVKN
The following text describes a protein:
Function:
Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries. May be involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MANNPRFSGVQPLQPPIVGSVEPPRSFVAPMSSQFRQVVPAQQSQQFNPVPSQHFYPVGLGAPRMNVGLPHHHALQPQFSQSMQQFPPRPGQPGQPGHATLPSQAIPLPIAQPNLHITSEKPIPQINSQTPNSYSPVLGGPERPLTSSYTFASSSYGQPHTNFSASTQYQFTPQMHAPDISSGRQLGLSSESQGTATVAQYAKQPLVPTTVTSATIIQPNTTRESPTDWIEHTSADGRRYYHNKKTRQSSWEKPLELMTPIEMLTGTWSATLLRGRTCCGYLLLSLATILLEYCRSMSLTSPKLFGLGGREKADASTNWKEYTSPDGRKYYYNKVTKESKWSIPEELKLAREQVEKASFMGTQPDTFEIPLVSTTVPPSVVKAPSGGETSSSPAQGVASSPASEGHDVAAGDLKPPLLSETPASTVVASTTDENANGTQTLLNVAALSDAVPENSEAAVTIASTIHAPMENADNLSAEDVPNSADGAPAKVVEGVDAIEALEEVKKDEIGEKLNDIGLEAKSVDPEPMIYANKLEAKNAFKALLESANVGSDWTWDRAMRVIINDRRYGALKTLGERKQVFNEFLSQRKKQEAEERRIKLKKAREEFKQMLEESSELTSSTRWSKAVSMFENDERFKAVERDRERRDLFDNYLGELKEKERARAEEERKRNVMEYRQFLESCDFIKADSQWRKLQDRLEADERCSRLEKMDRLDIFMEYTHDLEKEEEERRKIQKEELRKVERKNRDEFRKLMEEHVTAGTLTAKTHWRDYCMKVKDLLAYTEVASNTSGSTPKELFQDVLEELEKQYHEDKTRIKDAVKLGKILLSSTWVLEDFKFAISKDFSPPISDVNLKLIFDELLERVREKEEKEAKKRKRLADDFFHLLSSIKEITASSKWEDCKQLFADSREFSSIGEESLCREIFEQYISQLKEQAKEHERKRKEEKAKKEKEREEKEKRKVKQRREKEEGREREKDEEDNIKKQRKRHQSSEDIVDENEKDRSRKSHGSSDHKKSRRHASAPESDDESRHKRHKRDHRNGSRRYGDHEELEDGEFGEDRQSW
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSRARDLRAFQPQTPPNAQSGESSRSQRYPASATPANDFREREDPSLPPGSAPPMRPQRSAARQPGIIISNPPSSSNSTGTKHFSPAPSQGAPYETRYTHARGRSDSSNRLASSRQTPSGSNNRLYEAVNSRPDIARAPNSTSRIHANGNGYLDRDYRARDDDYPSEPRNQFSNDMVKRPSTASSTGSFDNEANRDLLSANDLKDAKRMHGARNIIEAFSSQAEKRSIQKARATRSPPLMDPSESRTIPSMFHDQSYPRTPGFGEIERVLQKIKLYWDATGIAGSSNQNEPFGYSVTPTAVPFSAVGLALDLLDSENPELAKSASRAKDMINKKGGVIPSLSSFLQLKAELEKALQLTIQGNYRQFDASVNCYKLAKVSVDSNYKKVAELKSKLVECRATLGNGSPSSAFNNAVGGKGTEMKGLQARREVLREMLKLIDTIERLKQVPERLESLISAKSFLSATVLLVRSLKVINKPELAEIGGLSDLRSYLVNQESVMFEMLIEELHNHLYLKNYFCNSKWRAYRPGQVTYPTSAHPSSYHAAASSSKHSNIENSNTPSSPIPHLRNYLNDLMTQPQSNPLVEEADLFLELSSISLHSELGTEDVRRMSTTTSGVTAKKRRNQSTNPELDSFKYIESLIESFAVLGKLSLGLDTVLQRVPVEVYTLVESTLNEVDERHENTKRFFRSSSASKNALKSNMNMIVLMNTTSQPSPSENPDLKSTANRTIQRFSLFKFNNNELRELESVIHILQDFFWTLYSKFDATLQSFRVLHEVSLRISERKSFKEEGMESNLVLFSLLEVWKPIQSELLALIHAYLTESGDDQFAASTTTSTTRNPMTSIAEVLKIGLGGATSTSNANMAWKDSNKQLFKFKDAGLKQSQKDFKTHEANLYSALKVSVPGLVLDSTTSNSQANGAVVLSTGVMMTDDNSGARGNSTHKLLVQPDAFHIAHLFKPTLEFLKRAKEVLPSGMNLAQFGGFSGFLDEFVLHTFLPQLEEKVIYMFEHSVNAPDAFQDDTSQQFETNTPDMNLGPHRQKMSSPMPVAKVQSLRAIVALIECLGSLLQSTSFHQEKYGRLMISIVVQYYQKCHERFKELVVRESMETTAIIDESNPHANLKLAADWAQKQEFIKHLTALKSSSTSTKKLLKKLCKTEERCLTSRAALVPIDLIQSPKKLAALAHLYNTLLSFISFIRRLGSAVKSIPDSEGESGLESERLTAEWYKEFGPSIKKSKQTRTTFQMPLTHALMRRFQLVHRSFCTLAQTILFTIHLELRLETYYHIEQTFVRGNYFLSRSDSIEPDLKIIELNSLINGYSESSIVKNLVRTEDRRFPFLGLVNLIDDLMITNVKKLSLANEIGFKKLAKNSIALQQNMKSILLNNRLLYHHQELSKDLQMNPNNILPVDVKSSLSFDLNFERCRKFWENASKGPQAVMESIRRGDNYRFEEYRKLLELLCLNDRNPATVRMSSGISHQHADDSHRNHAREDDSESNNRASLKFPDDFHDHTNLSIEKRKRIYNECLIELHALVLEDDDEDDEGEDELGSENIMGSLNKQINAGDQNVHSDHPE
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKSIVIVAGGTGGHISPGVALAEVLTELKEKIGYENLYLYSLVRNKNNPDLEQAPCPVLWHNLPPLSSNFFLFPIRYTIQIIKTFFIFKKLNIDVVIGMGGYSTVSSILYGIFFRKKIYLCEQNTIPGNVNRLFFRFASKVAFSLPPKNSKIPCDYQVLGNPLRKKTIPKMSLKFFEKYDTKKKKQFNVLVMGGSQGARQINNIVIALMSHEEINKQFRFRVLTGSALYEEVSKKSKKDAELISYSDNMKEHYEWANFVIARSGSGVLSECAAFALPMILIPYPYAKDDHQMANAKYFELNGAAIVVDQKDEDESHLFRVLDQMANDVNLLNDMSISSLECSHVDASKDTAKYFFSLD
The following text describes a protein:
Function:
Transports acetate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKRVLTALAAALPFAAHAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVHPKGTAIMSPGGLVQDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAYKDAAGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFRKGATEREELKVSKITVLVLGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLLTAVVLMILGPTIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGNREREQFRAQFIRSQTGFGVQQGRAH
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAKALDEVAASLRSIIDAIPKDAYAVEGGPTPQTAVVFKEEPAGEEDDERPNEAGGDRLQLHSDLAQYVATLRAHPVAFSGKFSVDSRCAGGQWTPGDVCVLSADITTAGPEAVSGSPAASPGIYAPGGGGEAQSSMAHGQPGISHMYGPPHPHPHSDPPYSCGGDMYQDQTAGAYLAPSTCAGPYHQHQPYNSAPKPPVDGALLSIIPEYGGFYQQSCQRDIQAAFPDRKSLAYPLESLRVAPPLTPLNTIRNFTLAAPSSAAEGPMAAAFPAHQNLPLRPILRPRKYPNRPSKTPVHQRPYPCPAESCDRRFSRSDELSRHLRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFSCQQCGRKFARSDERRRHMKIHLRQKEKKACAS
The following text describes a protein:
Function:
Transporter for gamma-aminobutyrate (GABA). Transport is driven by the membrane potential. Can also transport a number of GABA analogs such as nipecotic acid or muscimol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPYAEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNSVIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGDAPAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLYPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MPGFEYSSSPPSTPNRSTNSRYSFGTSNNPSTTPAGAPASSAGSYTPAGPAPSSFLGSTMGSPTPNKSAFGYSEYSQQSDFGHSQSDFGHSELQSPQFSSPLFTRPAARQQKVVFGSKSQKSQRNLRSPSRSEEEDEEEYDENTGFDTKTRNRYADSYNDDQDMGSEDVSYEDDDLNDHRGTKAMDSNIFNQHSNSVRFASTSGGQMRQSKGNELVDFQVSLAQSQGKKVPASDFASIAKTLSQSEGIPAVDEEDDLILKTEAIITKLYEQGVGKTDNEEKLQRALGVIPSELTALWQEYSERGVIYNEKEYALFIGPGPAASDFAKANYLAHLALQIHHSKPVEKGLETVVKPLPNTMLDWLEVNHDPFPHQLQEVQSTRPGPASHRLFWTTVLNNVVRGRLIGAINCLKSAGWRYSWSDAEDINAQGGAGGFTGVALTNVEKVMEDAVNVLSLCPAIQGDWNIHGSDWKVFRLRISQATEDLKQFAEGSSHPASGRSGKSSMRGSQGGDYSTLAKRAASRVPWNIYQNLLTLYSLVMGETIPIIENSQDWCEATIGFNDMVEVGLACLFQGDTESLICILRAWSGPVSSALAEVASLAGWLPRTEPQELLTNGELDQGDLDLLSFDKPALQDGVKDLTLIIYARSLQEVPELSAVIGNIEVTKEGWELAIAILGRLDSEKRSEEMVGEIMKTVKLDSAGIVDKLWRLLNDLDMRSQAEAIAMSYADSLARDNISPGEALWYYALAHNSDKVKDVLDTLIQLCLVYSTAYPSESELDDHLQRLISSPKDALNEMSSMDLEAAELVHTSLSGYATLRRFYSLRDQEVTSSPSSKPPMGVIARRSEAANALLALIISSDDNIRGGIYDEDRKAVIPVHYILALLGEAMPFVNQLDSLLSTSQIDILLRTIEDIQGIGPRIYSVCNAFLETVIKSGSGLKGSNPMDLLSKSSSGTSGSFAMVGSSMMASQFHKSVSASGLLNKGDIKRGWDWRNGITAGMTAQDILRVLRLGLAKDLARAWLQESDDIL
The following text describes a protein:
Function:
Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
Sequence:
MCGIFGYINYLVEKDRKYILDTLVNGLSRLEYRGYDSAGLAIDGDKKNEVLAFKEVGKVAKLKELIDSQNLDLEETFDSHCGIAHTRWATHGPPSRVNCHPHRSDPNWEFSIVHNGIITNYKELKTLLEGKGFKFETETDTECIAKLAKYLYDQHPTVGFTDLAKAVINELEGAYGLLIKSVHYPHEVIAARKGSPLVIGVKTQKRMKVDFVDVEYADDQPLPAETASQNVALKKSAAGLLSPNGLLGAADKSLLHRSQSRAFMTDDGMPMPTEFFLSSDPSAIVEHTKKVMYLEDDDIAHIHEGSLNIHRLKKADGSSNVRTIQTLELELQEIMKGKFDHFMQKEIFEQPESVVNTMRGRLDVANKTVTLGGLRSYIDTIRRCRRIIFIACGTSYHSCMAVRGIFEELTEIPISVELASDFLDREAPVFRDDTCVFVSQSGETADSLMALRYCLERGALTVGIVNVVGSSISMMTHCGVHVNAGPEIGVASTKAYTSQFIAMVMFALSLGEDRASKKERREEIMEGLGKISEQISSVLTQDRKIKQLCEERFRNQKSLLLLGRGSQYSTALEGALKIKEISYLHCEAVMSGELKHGVLALVDENLPIIMILTRDKLFRKSLNAYQQVVARKGKPVVICNESDAEFQTSDAVKIEIPKTVDCLQGILNVIPLQLIAYWLAVMEGLNVDFPRNLAKSVTVE
The following text describes a protein:
Function:
Carrier protein that may be involved in membrane-trafficking events associated with cell plate formation during cytokinesis. Binds to some hydrophobic molecules such as phosphoinositides and promotes their transfer between the different cellular sites (By similarity).
Miscellaneous:
MISCELLANEOUS: 'Patella' means 'small plate' in Latin.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasm. Note=Mainly membrane-associated. Also cytoplasmic (By similarity).
Sequence:
MSQDSATTTPPPPLTSDVSMPSGEEDEPKHVTSEEEAPVTSETNLKLPLMPELEESNHTAEVVSEKVTPETMTLESEGLNHAAEDSEQTHEVTPETETAKLEVLNHTAEDSEQTHEVTPEKETVKSEFLNHVAEDSEQTHEVTPETETVKSEVLNHAAEDSEQPRGVTPTPETETSEADTSLLVTSETEEPNHAAEDYSETEPSQKLMLEQRRKYMEVEDWTEPELPDEAVLEAAASVPEPKQPEPQTPPPPPSTTTSTVASRSLAEMMNREEAEVEEKQKIQIPRSLGSFKEETNKISDLSETELNALQELRHLLQVSQDSSKTSIWGVPLLKDDRTDVVLLKFLRARDFKPQEAYSMLNKTLQWRIDFNIEELLDENLGDDLDKVVFMQGQDKENHPVCYNVYGEFQNKDLYQKTFSDEEKRERFLRWRIQFLEKSIRNLDFVAGGVSTICQVNDLKNSPGPGKTELRLATKQALHLLQDNYPEFVSKQIFINVPWWYLAFYRIISPFMSQRSKSKLVFAGPSRSAETLLKYISPEHVPVQYGGLSVDNCECNSDFTHDDIATEITVKPTTKQTVEIIVYEKCTIVWEIRVVGWEVSYGAEFVPENKEGYTVIIQKPRKMTAKNELVVSHSFKVGEVGRILLTVDNPTSTKKMLIYRFKVKPLACE
The following text describes a protein:
Function:
Serine/threonine-protein kinase that acts as a mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Sequence:
MPLLSSLTFLPLYQLFSNFPLCYTCELAAKRSLSLAVPHQLRAQEAGVASGLSHLKHVWGQGIRKAGQWLRTRPVARSPRLRRLDPANEQGSTDLAALCASTLDKIGEPRNTSNTPRVSTQNVSEAACAPVSRACLQRGRVRDALKPPGSPKLFHSLSRPSRVPGSPGPRFSSPCAGRVSPFSGSSNSSQTPSLRGALVLLTPPGCGAGAGPTAEPPPTASRARRAGGLLGRLHLLFLKRRGADKRHHWSPGPSHRHTQRPAFRRRSGSGGGGNSAGRAPERPRSKSQGGPRSYPRRRSQSEPKAPPPPKQCGAAVAFMAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGEFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENSTHPEWSFTTVRKKPDPKKLQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MMMIIWVACLIIFWTILLRLWMEMVLLNWASKLGPIPSEIFREKLPPVGNCIVGGSSGGCGDSIDFLNSIDFLTVCCGPNVGTYEPTFQIKETLISGVKPQQPTFSQDKRLYGVPKSFEAPSPDSVLERRISSSACKTVLFGTEITIPVRTRTKRSWSGLTTNPWSKSLLLNPLQNVKKNRNLPQHDVNETKKCTHCEITRTPQWREGPMGPKTLCNACGVRYRSGRLFPEYRPTASPTFISSLHSNSHRKTYIVKKPLGSNIQTQKHTRLCS
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity. Could be responsible for the degradation of diet-derived D-alanine in the intestine. May play a role in egg-laying events and early development.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MPKIAVLGAGINGIASALAIQERLPNCEVTIIAEKFSPNTTSDVAAGLIEPFLCDDDVDRIINWTSATISRIHEYQADGNPGAEEQSGYWLQSVKSEPKWLKLMKNVHILTDAEMKQVARRPEHKFGIFYTTWYLEPTPYIKWCTDKFLKNGGKFKKQKIENIDDVARSYDVTVNCTGLGSRALIGDKEVYPTRGQILKVSCPRVKHFFIDDKYYALLNDSTITLGGTFEAHQWDLTINSELSQKILKENIHNIPSLRTAQILSSHVDMRPSRGTVRLQAELGRSLVHNYGHGGSGITLHWGCALECAEIVENVLKMKKSKL
The following text describes a protein:
Function:
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
Subcellular Localization:
Cytoplasm.
Sequence:
MAESPNQTVSPLRITPLGGLGEIGKNTWIFQVNDEIMLLDGGLSFPTEEMHGVNLVLPNIDWLIENQEKIVGMVVTHGHEDHIGGIPYHLQRLRIPVIHGPRLAMALLEDKLREAELLGRTQLQTVGPRGTVRVGKYFLVEYLQNTHSMADSYTLAIHTPVGVVMHTGDFKFDHTPVDGRKFDYQRLAEYGEKGVLCLISDSTNAEVPGFTPSERSVYPNLERYIKEAPGRVIVTTFASSVHRIHMLLDIAQKTGRSVCVVGRSMLNMIAKAKALGFIPNFSDSLLQPVQAANSLPAERVLVLTTGSQGEPMSALTRIAGGDHRQVKIQPGDTVIFSSNPIPGNTISVVRVIDKLMQLGANVVYGRERGIHVSGHGAIEDQKLMLALTKPKFFFPCHGEYRMIRRHAQTAQEMGVPAANMLLTENGDVVELTPESMRVVDRIPAGVDLVDASRSTMVNSNVLRERQRLAEDGFVTVAIALTPQGTFAARPQISIKAVARSAETRNLEDMLRTALERTQGRFGEFRQPLEAGALGYQYDWMGIKQLLERTVKQVTREMLQSHPLIQVLLQTPLEAPVTSLPLAVATSA