lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MAGRPIRIGDQLVLEEDYDETYIPSEQEILEFAREIGIDPVKEPELMWLAREGIVAPLPEEWKPCQDITGDIYYFNFANGQSMWDHPCDEHYRNLVIQERGKLSAPGAVKKKEKKKKKEKKDKKDKESSKSPQETQPEQGLLPSSSFLRGTSPLPAPGLADLDLDQEMQARSEGSFKKGKSPCALGDTPWPVMGSLPSKLQPLSKGQASRTHQIFADVEEILGRAPAHCRTELGYQQGLEKPPQPTEKIYLGFSDPEIEELEMRTRQQKPGSPGPENTGLFQNGQDALKSRSQASVPSKPLESLKGPQLKGEQHSHNMAKRGSTGPGGDKGQSPTPSPSPEVDPMLLARKSKPFLLDSSPAEDQSWQDVSGEGGSVGRSRYRREPLGLWLGQVSKLVHKDSPMGGWKTEPDGPEAPGKAARGPPQGLLLTSPDALASEPAVKPPEEDRKPGGFEPGLESSRSSSVASQLGSEVLGEVTNFPWDLQGLWGSECSVGHSGPGPREQYPGPSLGPHSSHLQSSAEKQLESEDYPEDQRFYQHILKMVKISKGLGQLESAQEMPCKDLASMVCCLAAESSRMSSEGEHEALGAMDPRFLPWGPELPECPLDVDVAPAGQAASQHACFQPSSSPLRQGLLKMSSSRASQDAEPGKMQLVDQALSSLLAPVHVPLGGLAPLRGLVDAPPSALRGSQSVSLGNSVESSQLGELFRPSQGLKASALERNGLLGSIHEDKNALGLLALGEETNEEDEAESDTSVCSSSELLKNLHLDIRALGGDFECEESPRTSQPEEKKDVSLDSDAAGPPTPDKVFSQGADDSLSSADGKGRRGRGARWLPEKEKNEKDDPGMSRDVADLGVYPGGDWPAGASRKEAPEDLVEAGEKGSRKEAAKGPEKKASALCPWWVLDFGFRSRISEHLLDVDVLSSLGGGWTEVRVLQSLALPLLSPCGPDSAALSRLSPPLLCGERLQSPLLSQATDEGPLQAPEGQPEWKGAEEPGEGSAGSPTPPLSLPREEILSPPVAHERGEEQRSQAEGPGPGQEEAKEPEEKVVVSPTPPVSPEQHPKVSLKAMEEAVAQELEQDQRQLLESKQEKMLQLREKLWQEEEEEALQLRQQKEKKKEDLVVLPATLPLLCSSLKEQLQRATEEEETRMREQQSQKLSQLRAQVQSSAEADEDKIRAEHEASLQRLREELESLQKAERASLEKRNRQTLEKLREELEASEKREQAAMNAEKERALRQLRQQLEGERKEALAALEREHREELERLSASLEAKHGEVVSSLQKKMEEAQQKEKAQLQENWGRAEQRAHRKAHQVLEYEQELSDLLREKRQKVEKEHERRMDKMKEEHQQVVAEAREQYEAEERKQRAELLGHLTGELERLRRAHERELEIVRQEQDRQLEDLRRRHREQERKLQDLEVELETRTKDVKARLAQLDVQEASARKEKQQLLDVQRQVALESEEATATHQHLEEAKREHTHLFESNRQLRKILDELQARKLDLESQVDRLQKHVSHLEAQVQRKQDLLKELALEESNASPQLEPDLRIEDLRKSLGPTKALSSSFCQSKETSLSLDSFQHYLSAEGLALRSAKEFLVRQTRSMRRRQTALKAAQQHWHHELASAQEAAKDPAGTMALEEVRRPGTETRHLDEMRSAVRKGHDLLKKKEEKLHQLESSLREEDADEDMLRGTPAKKVVTFDLSDLEDGSSESSESSGLTPRPTLPNKIHYLSSSLQQISSQLNGVLSVLGSLDPESPLPVPLSAQASRGTSVPSSPSLAQVSASPLAPPTPTQWAWDPGLGPRLSCSVAQSVDDFLVEKWRKYFPTGIPSLSTGPAHLENRLGYVSASEQLRLLQRPHSQVPNLGSTNFQHMLEANRKWLEHYKEDPKLHLFSSVPRPTAGSSLLQLGLDENRLKVYRY
The following text describes a protein:
Function:
Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.
Sequence:
MKIFLVQLASLLLLLLVQTPTSQGQAINDQAQQQHCGEDSVPLDCEDIYDQGSETDGVYLIYPAGPNTPVPVYCDMTTDDGKWTVFQKRFNGSVSFFRGWSDYKLGFGRADSEYWLGLQNIHHLTLKQKYELRVDLEDFENNTAFAKYTDFSISPNAISAEEDGYTLHVSGFTDGGAGDSLSYHSGQKFSTFDRDQDLYLQNCAALSSGAWWFKSCHISNLNGFYLGGAHLSYANGINWYQWKGFYYSLKKSEMKIRRV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MTTANQPICPSPAKWPSPAKLNLFLYITGQRADGYHQLQTLFQFLDYGDQLTIEPRDDNQIRLLTPIAGVENEQNLIVRAAKMLQKHPGNTPVPRGADISIDKCLPMGGGLGGGSSNAATVLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAFAEGIGEKLQPAEPVEKWYLVIHPGVNIPTPIIFSDPELKRNTPIRPLAALLSTPYANDCEPIARKRFREVEQALSWLLEYAPSRLTGTGACVFAEFDTESSARQVLSIAPEWLHGFVARGVNVSPLHRVRSGKIESSERR
The following text describes a protein:
Function:
Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver one or more Fe-S clusters to complex I subunits.
Subcellular Localization:
Mitochondrion.
Sequence:
MTRFTYSKLSHFLKTLSCRPPAVRAGAETKAATSCCVQLKRDQSSDSRALQDRQRQQMARGLPKQKPVAGVKQVIVVASGKGGVGKSTTAVNLALAIMANDSSRTVGLLDADVYGPSIPKLMNLTGNPQLTDNNLMIPLTNYGVPCMSMGFLVEDTAPIVWRGLMVMSAIERLLRQVHWGSLDYLVVDMPPGTGDVQLSITQNIPIAGAVIVSTPQDIALLDARRGAEMFKKVNVPVLGLVENMSVFQCPNCNHQTHIFGSEGARRVAETLGVAFLGDIPLHLSIRETSDVGQPVVVSAPDSSEAKAYRKVASAVLQRLQEVS
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MALQWMILTYVVAAEAALAFLLTLPAPKLLKNQFVSLVSLILQPALFIVPFAGFQLLDIYWKNEHRLSCTSEICTAAERDRYEKSIYKAQRNVILCASACLLYCNLQMLGAGVLFAYANITRTFRIWKKLRRGARRSSFSQIGFCLGVETTEFINFFFIINGKPM
The following text describes a protein:
Function:
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MVQSCSAYGCKNRYQKDRNISFHKFPLARPEVCVQWVSAMSRRNFKPTKYSNICSQHFTSDCFKQECNNRVLKDNAVPSLFTLQTQDPFSADVCFPLNVCATAEPLSECFPEQCGLPDGQEAGAVSCPEQCVPPGGQEAGAVSCDHNYTLEDCVQQKRRVQRLQEQMEKLRRRMKTLQQKCRRQERQLERLRANRGPAPLGDRYVILPRELYEELQGVETIGAVH
The following text describes a protein:
Function:
May be involved in heavy metals transport.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MGRVTTPSEEDSNNGLPVQQPGTPNQRTRVPVSQFAPPNYQQANVNLSVGRPWSTGLFDCQADQANAVLTTIVPCVTFGQIAEVMDEGEMTCPLGTFMYLLMMPALCSHWVMGSKYREKMRRKFNLVEAPYSDCASHVLCPCCSLCQEYRELKIRNLDPSLGWNGILAQGQGQYEREAPSFAPTNQYMSK
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MLFLDDFLEMLDELPAELKERSDEIRRIDNEVESRLNRNREAINDFFERTGVNMPEEQRKERCKVLQEEFSTIRVLAQRKYLIAEKMQELLKKYKVHLEKEKTTFQCEMEADNSGVTEMIEKRYTQHVESLLTARKERKRRHRVGGGGGGGGSSSRASTVASGPLLSKESKDKIQRILQEGVRLRMDLSDESAQSALSSAIPSPAPRGRPPKIAKDQLLLSSAAMVVASDDCLTPVPPTPTARRRSNTNALRGTVSIPSALSSMMNRGESTSRFSPNPSERSWSNAGIDESSPTPTTSLLMTPTFSSGPHIVVSPTTPVLQNSAFVVSESRHGRTRKLTSRVQEMFKETLQRQRNHGNSIIALQERMSAANLAAAAQHAHAPTSSSPQSPLPEIEGAAEDDDEEGPSYRIKRSHPMMAPGSEDEEDEMHWCFCNEKSYGDMVQCDNRHCTLRWFHYPCIGMVEPPTGKWYCPRCEVTMGIALKLSEEGEV
The following text describes a protein:
Function:
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MGDRFFDRDFSSGGSGGFDRRGRGGYQQRDNRGFQDRNGGGRRPSLPIPDEPPFEVFVGNLFDGIVEGDFEQYIFPDAKIRSIRMVRDRMTNKFKGIAFVEFEDRQSLVAALELDGVEVNERRIRVNVSEGKGKRGDRKNFREGSAGGPPSGGPPHGGQGGRFQDRPQHDRRDGGYERRDGGYERRDGGYGRRDGGFDGRGRSSASEDLKPASTTPAPGRPRLQLKKRTVDTPVGAVSETDSAVFGGAKPKEEKEDAAN
The following text describes a protein:
Function:
Protease which deconjugates SUMO from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubql-1 in the export of ubiquitinated proteins from the nucleus to the cytoplasm.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLTDLFYSTFGCLYSPTSTMDVMGTARRKTVVRLNVYDMYWLNDYASNIGVGIFHSGIEVFGVEYAYGGHPYQFSGVFENSPQDAEELGETFKFKESIVVGETERSTSDIRKLIKSLGEDFRGDRYHLISRNCNHFSAVLARELTGKDIPGWINRLANLSGSIPFLEKCIPQEWLTPIVLQASVDEKKRGSVDSAEEATEKLVVRSLNDSRTTILDNRTANGAIIMSASSSNSDRICMSPSSSSSASSCDTLDYDDLIVQTPSTFSSEKKSRSNSPPIFRIWNTIKATINGTQQTAPTGAATVIPASSASNIGKTNSTPGTTSNGLAKPTCSEC
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MECGGQLDDMETLPQRPPAAKKKNCVRCGKDAVLVVQTSAAFCRECFLNYFTHKFRSGLGKSRVVQPGEKVLLAFSGGPSSAALLHLVKRGMEEGTQKKRLRIEPGVVFIDEGSIIQGFDVDQRQRSVQTISKIAGESGFPVHHVMLEDITTVQATEADLPVSNCAGTSPATTEDVERQVKSLSTDDTSADRLKRLFEEAKSLTAKEDLLQILRSKLLVRVARTHGYTKVMVGDSGTRLSVRIMADIAQGRGAALPLNTGFADDRHGDVVIVRPMRDFIAKEISMYNTICQVESAFLPTLTTRVAEKASIGHLTEAFISGLQVNFPSTVSTVFRTGAKLCVSDTENRPEGYKRCAMCKAPLDTGQQGLLQSSVYKTSLAADDESDGGVVTGQDLCPSLCHGCSLTVADFGDFSTLSDSDQLFT
The following text describes a protein:
Function:
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
YALVCLFGIGSWVALNGIWVELPIFVKHAPEAWNLPSYLAIIVQLANIGPIVYGFGNHWAKNVCNEWTAIPLIVTIGAVSCFLLAYFWDRTSLLFGANHSTALLALSFTLSLVDCTSSVVFLTFIGTFPAPYLTALFIGETLSGMLPSFVALGQGIGDPCNSTLIQNTTILVNDFESTDLYVGKGLKFGPEEFFFFLFSMMVVCGLSFLALNVLPFAKRQQILQRPDHRTNFSEVNRHLLSENEFVSYGPHGSISSDTSAPDDEQVPPAIVYQPNCSSRQVVYLLFVQVWINGLANGVLPSTQAYACQPYGSQAYHLAVTLTSISNALTCVLALWLPSQSTSIVTIFACIYNILSGYLLLLASLSPTPPLYNTLMGSIIMVTVSVVSGSLITYTKLTICTIMKKKGQRALFWCGVAIQAGSCIGALVIFPVVNVAKAFHQAKQQC
The following text describes a protein:
Function:
Bifunctional adenylate cyclase toxin-hemolysin that plays a crucial role in host colonization. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function; [Calmodulin-sensitive adenylate cyclase]: Adenylate cyclase that is activated by host intracellular calmodulin and catalyzes un-regulated conversion of ATP to cAMP, thereby impairing microbicidal functions of immune effector cells and inducing apoptosis of lung macrophages; [Hemolysin]: Hemolysin that forms small cation-selective membrane channels, leading to hemolytic activity. The hemolytic activity of CyaA is weak compared with that of the HlyA of E.coli (By similarity).
Subcellular Localization:
Secreted; [Hemolysin]: Host cell membrane; Multi-pass membrane protein.
Domain:
The Gly-rich region is probably involved in binding calcium, which is required for target cell-binding or cytolytic activity.
Sequence:
MQQSHQAGYANAADRESGIPAAVLDGIKAVAKEKNATLMFRLVNPHSTSLIAEGVATKGLGVHAKSSDWGLQAGYIPVNPNLSKLFGRAPEVIARADNDVNSSLAHGHTAVDLTLSKERLDYLRQAGLVTGMADGVVASNHAGYEQFEFRVKETSDGRYAVQYRRKGGDDFEAVKVIGNAAGIPLTADIDMFAIMPHLSNFRDSARSSVTSGDSVTDYLARTRRAASEATGGLDRERIDLLWKIARAGARSAVGTEARRQFRYDGDMNIGVITDFELEVRNALNRRAHAVGAQDVVQHGTEQNNPFPEADEKIFVVSATGESQMLTRGQLKEYIGQQRGEGYVFYENRAYGVAGKSLFDDGLGAAPGVPSGRSKFSPDVLETVPASPGLRRPSLGAVERQDSGYDSLDGVGSRSFSLGEVSDMAAVEAAELEMTRQVLHAGARQDDAEPGVSGASAHWGQRALQGAQAVAAAQRLVHAIALMTQFGRAGSTNTPQEAASLSAAVFGLGEASSAVAETVSGFFRGSSRWAGGFGVAGGAMALGGGIAAAVGAGMSLTDDAPAGQKAAAGAEIALQLTGGTVELASSIALALAAARGVTSGLQVAGASAGAAAGALAAALSPMEIYGLVQQSHYADQLDKLAQESSAYGYEGDALLAQLYRDKTAAEGAVAGVSAVLSTVGAAVSIAAAASVVGAPVAVVTSLLTGALNGILRGVQQPIIEKLANDYARKIDELGGPQAYFEKNLQARHEQLANSDGLRKMLADLQAGWNASSVIGVQTTEISKSALELAAITGNADNLKSVDVFVDRFVQGERVAGQPVVLDVAAGGIDIASRKGERPALTFITPLAAPGEEQRRRTKTGKSEFTTFVEIVGKQDRWRIRDGAADTTIDLAKVVSQLVDANGVLKHSIKLDVIGGDGDDVVLANASRIHYDGGAGTNTVSYAALGRQDSITVSADGERFNVRKQLNNANVYREGVATQTTAYGKRTENVQYRHVELARVGQLVEVDTLEHVQHIIGGAGNDSITGNAHDNFLAGGSGDDRLDGGAGNDTLVGGEGQNTVIGGAGDDVFLQDLGVWSNQLDGGAGVDTVKYNVHQPSEERLERMGDTGIHADLQKGTVEKWPALNLFSVDHVKNIENLHGSRLNDRIAGDDQDNELWGHDGNDTIRGRGGDDILRGGLGLDTLYGEDGNDIFLQDDETVSDDIDGGAGLDTVDYSAMIHPGRIVAPHEYGFGIEADLSREWVRKASALGVDYYDNVRNVENVIGTSMKDVLIGDAQANTLMGQGGDDTVRGGDGDDLLFGGDGNDMLYGDAGNDTLYGGLGDDTLEGGAGNDWFGQTQAREHDVLRGGDGVDTVDYSQTGAHAGIAAGRIGLGILADLGAGRVDKLGEAGSSAYDTVSGIENVVGTELADRITGDAQANVLRGAGGADVLAGGEGDDVLLGGDGDDQLSGDAGRDRLYGEAGDDWFFQDAANAGNLLDGGDGRDTVDFSGPGRGLDAGAKGVFLSLGKGFASLMDEPETSNVLRNIENAVGSARDDVLIGDAGANVLNGLAGNDVLSGGAGDDVLLGDEGSDLLSGDAGNDDLFGGQGDDTYLFGVGYGHDTIYESGGGHDTIRINAGADQLWFARQGNDLEIRILGTDDALTVHDWYRDADHRVEIIHAANQAVDQAGIEKLVEAMAQYPDPGAAAAAPPAARVPDTLMQSLAVNWR
The following text describes a protein:
Function:
May be involved in cell wall organization and biogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSGHDSVTKISHILNEPVNEKVMVQNGFHESSKIADIELEIQERPSIKQWESPRSAVIPTSNHNFSPFLYTQFKSRGAAPFAPETIKSVDLVELPEGVPARVFHEKTGLFYQISPHSIPTFILAKKELPDPIKFYELVEDLGSVYGCVKLKIIPDADKFTQLNVDVDRLWFKARKQFFNSNEFQRTKIVDFYAKLYNFHNKIKKSTLTRIPSIDKRTLDLYRLRSCVKLRGGFNAVCEKKLWAQIGRELGYSGRIMSSLSTSLRSAYAKILLDFDIYEEEEQAARNNEKNEDMVESEIFRHSNSRSRDEEEPLHKKAKIHRDVFRAGSINHEFKRMRDIKHIKGFPTYFNSLTEFKLGYTQSTETTLPGYDFTFWENGMEIYDKSKYETKTSPVYNLRQYYEKSLAVFTAIVAKFGSSYPDLFAKHTTLPQKEFERLYFHLLSEHFIDFEIDTGLGLPCSMRSPGNNSSNEKFAIKNILDQWNLDNIPLNELSLLQHLDLDMANFTRTTYDIGMLFSCQGWSVSDHFLPSIDFNHLGSTKLVYSIAPKDMEKFEALIARGKSEWDTIQSRPRYSTSDDELKSFIETDFYKSFLDAEQSADYSNTGDNSKNSFPEDKIAGNTLHDGSQSDFIFEPNFILANGIKLYKTTQEQGSYIFKFPKAFTCSIGSGFYLSQNAKFAPSSWLRFSSEAAKWTSKMGFLPGLDVNQLLINALLNSNNPVLRKKCRDLISNYVVEEAENSKKLGELIGTVDVVYNKLNYISDISLESTGLSKIVVTHGALQRNLSLKEFVVLLEKPENGAHSICGIPIRDQSGNLNVCLHSYFDSASLGIALDGLDKPPTSYLLVHNEDFEKKWDVLMTSTFRNRTVPLNIIQYLISHTDSNTEFNRMLRSNFDDSLLLIEKCKKFIKTFVDVSCSVKDVDFGNGFNLRHLPLKFSDNMADNLESLYESVRKCSIEFSEKPTIIRLYHVSRQFPIDNRDIIDGNNLDLLKELYQKSLTIPLKVSYWTKLTRKICRLEWLSVYEHIFIERCDIKNEDPAKYSLPLLYSYFEFGLKYCDSEDIDKLGEVRKLILKYQDMMQKVRVFLKKDPPSKISLSDLEDVLLDIEEYRLPIQSSFFSELDYVIREIENAKKMNDVNILYNTDNIDKIDELIRKNDPKFVKFANQFNGSRLDKRPLASDNSGSVKAKQELKVFKLWNQHLDQIMQKNKFIEILPSIFRCLDLKSDKYIPLESCSKRQTKYCFCRRVEEGTAMVECEICKEWYHVDCISNGELVPPDDPNVLFVCSICTPPCMAVDNIEGVTFELDDLKRILVESLKLSLIPDPPILKNLFDVFAFALNFKNEMEKELFTNGYVNQLSSTHKIKYYLRKLKGSQCGFTNLTDPLRKHCQVKDAEAIKWLTDNGRIIITGIPN
The following text describes a protein:
Function:
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAQPYLPAEKFLSRKQETILLDEDVIYWKRMQQLTVFQEPAVVSSVRISPKKPYHVATTSSVRLTLYDTVVCEPLNLFSRFKKGVCSIDFRHDGRLLAIGGDEGKVRIFDVEKTTGSSKVALRVMQASQSTVKSVHFSPRGDTVFSMADDGKIKQYRVADTAYGVNAVPIIEIQAHEDAIRCGAVSSINDHIVLTGGYDHKVRLWDIRSKEKSLELDCEHPVESVLFLPGEQLIATAAGPIVKIWDTTTGRQLTALQAHYKTVTSLRLATNSTCLLSAGIDRRVNAFRTTNYSLINSWSMPSPVLDIDVSRDDQTMAIGMGNLLALYRRAEIKKEATASAAIEDKRSLIRTSAPPVKLVEKDRDMQKVDVVAKNADKLKIPKIDGMLSNFKHAAVIKLLFGGKFRSAMDTAVVSYLRVIVMRGAIHRALAGQERSVQKNILVFLNHNLYKAQYFSTLKEVVNAFFDVYALEKLDKDVVKHVQSLRGSLGRELEVQKMISSLIGSIDLIVSTTKMNVKSSSTALIEDNDVFGEPTIRARDLDELKPSDQGAEEEYEENMQIN
The following text describes a protein:
Function:
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
Subcellular Localization:
Cytoplasm.
Sequence:
MPATIAVTHLGCEKNRIDTEHMLGLLAQAGYQIDSDEDKAEYVLVNTCSFIGPARTESVRTLVNLAEQGKKIIIAGCLPQMFRDELLKEIPEAVAIVGTGDYHRIVEVVERSRTGERVSLVSATPTYIADEHLPRYRTTTEAVAYLKIAEGCDYRCAFCIIPHLRGDQRSRPIESIVAEAKQLASEGVKELILISQISTNYGLDLYGKPRLADLLRALGEVDIPWVRVHYAYPTGLTDELLTAVEQTANVLPYFDVPLQHSHPEVLRAMNRPWQADLNTRLLERIRERLPEATLRTTLIVGFPGESEAHFAHLCAFVERSEFDHVGVFAYSREENTAAANLEGQIPEAIKKRRRRDLMRLQQTISQRRNASQVGRVVPVLIEQENTQKKVWLGRSARFSPEIDGQVIVCGGAALNQLIPVRITAATPYDLCGEVFQA
The following text describes a protein:
Function:
Transforms N(2)-succinylglutamate into succinate and glutamate.
Sequence:
MLDFLAITLSGKPPQVIQGETVNLKWQWLGEGILTLVPHRSYTQSVVISAGIHGNETAPIEILNQLVTDLLAGQLPLSVRLLVLLGNPPAIRKGKRYLSNDINRMFGGRYQHYTPSDETRRASTLEQRVMAFFQASHTSERLHYDLHTAIRGSYHPRFGLLPYQQTPYSAAMFRWLRDIELDALVMHTSAGGTFAHFSSERCQAASCTLELGKALPFGENQLSQFSAITQGLRSLVSDSALPARKTENMKYYRVVKSLLRQHPDFKLRVAEDTVNFTRFAQGTLLTEQPNDNYRVEHPYEWILFPNPHVALGLRAGMMLVKMCESELPIT
The following text describes a protein:
Function:
Together with unc-5, involved in touch neuron axon guidance. During gonad morphogenesis, plays a role in the unc-5-/unc-6-mediated migration of distal tip cells along the body.
Subcellular Localization:
Nucleus.
Sequence:
MSSIRNQNDNRRPTFRDHRTPQFSGRGGSGGGGRRLQNPAHYPQRRDMSPIRRSSAISPVRRSQDHRQRSPEVRRHRSPEKESKDAVVTSTGSSRGATSASVTSSSRRHESGERHRETHRREDKEKKPEKSTDRDADRSNNIAARIQAPVVSSSTHHHHSNRHENRKSTAVKRPAADNRPMTYSTDVSVSRHSENRRKSSSDVSRRHGDKEKRDRKREDVKKKSNGERSSSSGRRREEDHKRKSESSRKEKKDEDVKEKVVDENKVEDEAVEMQGLVEVDCCEEEETIEQAKEHGSDEPERPESHQSAHSAAVSNASHHSDSEEELDYEEDDIDVDLDGDIDVETMKMAARGDLKVDDTTDEDEINDVKDETMEEQKEDGEPEKKKPRTSENDDKDKKHHGSSSSNSHRRREDDKDRRQSSDHHKERRRSPATRQRATDHKESRRSEGTSTRVESAASAAGTEIQRIPSLLTMRIAAPPGIKKLETLYHSGSGGSSSSSSHSSEMIIVGETFSNRWCQCSCAHHLPTTSSAAAAAGSLDASPASSSSSSSNSDASVSRIPSLMSLRTPFNNSCLFLAPPPPPSSSSSSKRSHEAAARIRAPSPPRRSFGDRGNRSDEHHGGSRHMDVGPQRRRLQDHRVRDDGRRVSSFEDRKRPERGFQDSGRVSLSLKHL
The following text describes a protein:
Function:
Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). Involved in responding to mitochondrial damage. Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa.
Subcellular Localization:
Nucleus.
Sequence:
MYNYNYSRGNKSMGNPPRFHELTDMPDNGASTSAAAGMFTRQDSLALAASLQQRDRERNPVDFMETQLDLDNYLQCFTDLDVPADNVDLNDAELQKANILYDDDSYEQPQLNPYERHVAYGPGFRNPGEYEEQDGYKMNFEVKTEEEKKPETMKTSKTMTTRRAIKRPSCYDDYQEEGETSLSDNDESVDDSYYKPKSSKKTAAAVPNFVPKTKARKYNLKPDKEKVEPIYKLKRARNNDAVRKSRNKAKELQLQKDEEYDEMKKRITQLEAELQSEREGRERDQQLIKQLIREKESTSKGPRKSSRNALESFNKSNY
The following text describes a protein:
Function:
Protects actin filaments from depolymerization (By similarity). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm. Required for development of normal skeletal muscle morphology and muscle fiber type composition. Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue.
Subcellular Localization:
Cell junction, adherens junction. Cell junction, desmosome. Cell junction. Note=Colocalizes with actin stress fibers.
Domain:
Xin repeats bind F-actin.
Sequence:
MADAQMQVAPTPTIQMRTEEDLSLPHPSAPEGLPPPPPKETFSKFQQQRQASELRRLYKHIHPELRKNLEEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDAIGDHERPAAREPVSGGNVQATSRKFEEGSFTNSSDQEPEGLRPSGGDVQAARQMFETKPLDALRGQEEATQTTMREPAATGDVQGTRKLFETRPLDRLGSRPSIQEQSPLELRSEIQELKGDVKKTVKLFQTEPLCAIQDAEGTIHEVKAACREEIQSNAVRSARWLFETRPLDAFNQDPSQVRVIRGISLEEGALPDVSATRWIFETQPLDAIREIEVDEKDFQPSPDLIPPGPDVQHQRHLFETCSLDTLKGERETEAEVPPKEEVIPGDVRSTLWLFETKPLDAFRDQVQVGHLQRVGHQEGEGLVTECLPSNGTSVLPLSQGVPQNDGLKGDVKTFKNLFETLPLDSIGQGEPSAYGNINRGQNTDSAEQSQGSDAPVYAMQDSRGQLHALTSVSREQVVGGDVQGYKWMFETQPLDTLGRSPSTIDVVRGITRQEVVAGDVGTTRWLFETQPLEMIHQQEQQKPEEEEGKGPGGPPPELPKKGDVQTIRWLFETYPMSELAEKRESEVTDPVSKAETQSCTWMFGPQSLNPAEGSGEQHLQTSQVPAGDRQTDRHVFETESLPASNQSSGRKPVRYCSRVEIPSGQVSRQKEVFQALEAGKKEVPETTINLGSIPTGSVHKFTWLFENCPMGSLAAESIRGDNLQEEQPKGSAGHGTPERQETAAERTLRTLHATPGILHHGGILMEARGPGELCLAKYVLPSPGQGRPYIRKEELVCGELPRIVRQVLRRTDVDQQGLLVQEDTAGQLQLHPLMLPGPGDPGNIEDMDPELQQLLACGLGVSVSKTGLVMQETGQGLVALTAYSLQPQLTSRAPERSSVQLLASCIDKGDLHSLHSLRWEPPTDPSSGPATEESQRVPPTESIIHVTPLDSTMEMGQLRISGSTPCPPPSRAAGKVVLPNGKPVAQAPLQEARKKRDISHAGQKGKAASGRPEASPLGSGAPDLQEAMQNLRLATAEAQSLHQQVLSRHPQGSDPVATSMPVQDVLQASTPATGVTQGSIRPVAGSEARIPAVPRKLL
The following text describes a protein:
Function:
Permease for high affinity iron uptake.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSATGNKVFAPAIFFIAAREALEASLVIGILSGMLENLVVHTKSAEDLAAHDSLTESEKHEVEQKKRALVRKLRKIVLLGALTGLLIAFAIGAAFLAVFYTQVNDLYGKAEELWEGIFNLVAVLLITPMSLAILRAGNSKRKWKRKLENAFSHQNIQPNHRRDEEGEATVVNANHSDDSASASSSSARQAAEEEAGTKTTRTEKLNPLEAVDVVPSMSGDQRRKRGGLRGLFSKPSGAVNDLKLRMNRGTLALFTIPLITTLREGLEGVVFIGGVSLGLPATSIPLPAIVGLAVGLGIGFLIFRSGNLVSVRIFLVFSTCFLLLIASGMASRSVYYLQFYAYVQLVGDSAAESGDGPGSYNSQGYIWHFNCCNPEANKGGTGWGILNSLVGWNNTATYGSVFMYIGYWFAVAGYLWYQIWSEGRLALRFGGKTYWESNRSIQARQRKQEKAHQRQLREADQEEHGHSSNSDKQQHPSEAGPSTLSH
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAPVRKSEEEVGQIWDRCFIDTSIKAAGGTIIGSIFSVIFLKRAAWPITLGLGAGIGAGYTNCRHHLWWNRFHHHSNHGHFGHKPGHSFGHAHPPFWGPPGFRREGEEKRYEKKTYKEMSPVNDFKDKDPPTQPDKPVDAGNH
The following text describes a protein:
Function:
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.
Subcellular Localization:
Nucleus.
Sequence:
MTAPRRWRFAMVCSSNMNRSMEAHAVLGRAALDVESYGTGSQVKLPGPSMHEPNVYDFGTPYGGIYDDLRRKDPDLYKRNGLLPMLKRNISVKLAPQRWQDNTGDGVFDMILTFEERVFDLVVEDMNNREQRLLKSVLIINMDVKDNHEEAAVGAKLALDLCHKLEAVADDWEEIIDDLVAAFEKQHKRKLTYYISFY
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
METDELNEDVLPMTNAFKLLCEDFTPEHNKKEVEKQRQTAKNIKNELENAKSDLKIEYKNLDFWTQHDIKHPLHHLQKAISATTSSVTDFKWVKPSKISISEISATKKLQIFVEIPSELFGNRDYLNLTYPAKRAHFLCFAAKFLAGKFEKIEFMAGGINRDDPIFPDLIVGGVRIGFYTSELAKTKRFVPSIGNLRPVTVFGENLFKGEFWPNFGRISKFQTHPTALLALHLLQSVLEHRHLNLEFSPVVLTARIVRLIKNGQITEKQEILTVLRVIFKDFISWSADVEYLDVNDEQMEDDVEEEYSQHFDVNLIWRHLNIASRISKNQMARMKKELATCYPLLGQVYTFDPIFIDKSPVFAQYDHVARLQINVAQLTPLLGEFGCDSVDNRDVICQFLRSLEHRIEQTMSERYEFLGIHEILDPAHATWKLGEYASQQRQKTFLVGFRSTSAWKNPLTVGPSAQTNEAKEFRTLWKDTSELRKFADTRICECVVWNEKPSDKVPRAILQFVLQKMFHLPATCLSWRSLTSSSNSSEADRAHEKKSQEAVFQAFTDLSMLLRGLKGIPLMITNVHGVSGYIRGSEPAYPSVFAAATSSGKDSGERRRHVVPEAGKIPLYSPAVTVHIKLEYSGKWGNDVEAIRRLTSSLYVKLKNVVYSLFQIAEKLRSEHKLCAVPTIDQLFVLKSGIVFKIVVVNDRILSILEENVQKLKDSGASRIESSIQGMRLAMWKKKFIAEPLLQMSLQSFATSHKFFGSTVQLFKKWLGAKMLSGHLNDHIIELLVVAAISKRGAVEPQSTWSSFSRLLDLIATHPWSARPLFVDFGLKSWSEEERSKLEEKFVKMRPILPPMVVIHEEDHQGMKFTRENPSGIVLNRLVAVAKDALKLVEKQTTGEKSIDLETSLLTENLSPYDAVIHLEPPAVVRKKALLERRPIPENPKFQPKIPVVELDPVDELVYQLNNNFHAVAMFFYNKYGGHNIGVMFKPQEEEVPAKISRCSLHKSISDTVLRLNRAEILENIQIMGEGVVADVELKKA
The following text describes a protein:
Function:
Has ribonuclease activity towards yeast tRNA and polyuracil, and decreasing ribonuclease activity towards polyadenine, polycytosine and polyguanine respectively. Lacks antifungal activity against M.arachidicola and P.piricola. Inhibits HIV-1 reverse transcriptase.
Miscellaneous:
MISCELLANEOUS: Inhibits HIV-1 reverse transcriptase with an IC(50) of 300 nM.
Sequence:
DADIAVWAPPVNAQN
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSAIFNFQSLLIVILLLICTCAYLRSLVPNLLDKNKTGVLGIFWKCARIGERKSPYVAVCCVVMAFSILFMQ
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MLGIVKMEGHETTDWSNYYQDAQEGYSSVPVSNMPQGLATMNTYMTMNPMSSGSNITSGSFNMPYGNSGLGAGLSPSGMSGMGSAGAMNGMGSGVPSMGSALSPSNMNAIQSAQQASMNSLSYSSMNSGMSPMGYGATNINRTRDSKTFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFIKVSRSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKTQGGKGNQDGRKDHSGPSSPLHRVHGKSSQMDSSSSMSNPSSSPQALEHNGSNGEMKPQVAAGPSPLSSHQNHSTHSLAHETHIHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQQYSSYGGGLQGMPLGSPSMTGRGTIEPSALEPTYYQGVYSRPVLNTS