lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nucleolar component of the spliceosomal ribonucleoprotein complexes.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MANSTLFVRNLPTSACSDRLEEIFSEVGPVKHCFVVKEKGGETCRGFGYVTFSMEEDAQKAMKEIKQYDGQQIVLMLAKKKQHNKKKSVIKVNTSSTSTEPGPKKQKPKSTKKSKKKARLIIRNLSFKCTEDDLKQFFSKYGAVLEVNIPRKADGKMRGFAFVQFKNVLEAGKALKATNLKEIKDLTNISDWPIFTSVLLLETPASSLVPSEIRTTKNKTKGKLITRGKRNQDIMNASAVKIESNNEKDLFASGQDNVYEDIHLPERKIKGPFMEIMYNKMCYMTVLHWWIMKNTQTCLIWFLALNQYLQNKTNRFKIEEYVKRTGDFKHNRTQLDKRPGKKAPVETEECEIDDDTESSDEHSAAEDHEEENDAESEEADSDGSDSGSEDEEDNEIPAQKKHHTSDVNEGKTVFIRNLSFDTEEDGLEELLLQYGELKYVRIVLHPDTEHSKGCAFAQFKTKEAAEKCIAAAEEGSESGGLRLDGRKLNIVLAISREEAMKVKTQKVKTHTGTRNLFLAREGLIRAGTAAAEGLSAADLAKRARFEELKRLKLRDINVFVSKTRLCVHNLPKSVDQKHLRKLCLKAAGGGKDVRINECRVMYDRKPQLGKTVGRSLGYGFVQFQEHDHALKALRHLNNNPDIFGPQKRPIVEFSLEDSRKLKIKENRAQKSKQNVAKAGENNKSKKSSKVLECGQKREQDHSESTSSRLSDIVDVGEKKSGHWSGFQTKPEVEKVELEDGKKRRKILDLPSHRGPKIRKRDKGKQQQVQPKKVRDQPSRKERIKSVFIEKQSQQRNQTSKKMKNTFRRKEDDRFDSLVEKYKKTILGNPKSSIVKKGKWFIS
The following text describes a protein:
Function:
Involved in the initiation of the fatty acid biosynthesis. Catalyzes the condensation of acetyl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protein (ACP) to make the fatty acid synthesis (FAS) primer beta-acetoacetyl-ACP. It can also use short-chain acyl-CoA as substrates, including butyryl-CoA, and hexanoyl-CoA, but does not use any of the longer chain acyl-CoA substrates.
Miscellaneous:
MISCELLANEOUS: FabY is a FabB/F homolog that functions as a FabH.
Sequence:
MSRLPVIVGFGGYNAAGRSSFHHGFRRMVIESMDPQARQETLAGLAVMMKLVKAEGGRYLAEDGTPLSPEDIERRYAERIFASTLVRRIEPQYLDPDAVHWHKVLELSPAEGQALTFKASPKQLPEPLPANWSIAPAEDGEVLVSIHERCEFKVDSYRALTVKSAGQLPTGFEPGELYNSRFHPRGLQMSVVAATDAIRSTGIDWKTIVDNVQPDEIAVFSGSIMSQLDDNGFGGLMQSRLKGHRVSAKQLPLGFNSMPTDFINAYVLGSVGMTGSITGACATFLYNLQKGIDVITSGQARVVIVGNSEAPILPECIEGYSAMGALATEEGLRLIEGRDDVDFRRASRPFGENCGFTLAESSQYVVLMDDELALRLGADIHGAVTDVFINADGFKKSISAPGPGNYLTVAKAVASAVQIVGLDTVRHASFVHAHGSSTPANRVTESEILDRVASAFGIDGWPVTAVKAYVGHSLATASADQLISALGTFKYGILPGIKTIDKVADDVHQQRLSISNRDMRQDKPLEVCFINSKGFGGNNASGVVLSPRIAEKMLRKRHGQAAFAAYVEKREQTRAAARAYDQRALQGDLEIIYNFGQDLIDEHAIEVSAEQVTVPGFSQPLVYKKDARFSDMLD
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MFFKALFLSLYLFFFISYAEIIFCIRIKRNNLYNFQNMTNSLNIKNLDDVKEKVKYEKHTYCLLLDKYKVNKILKNKRAKFWLLDIYKFPSVLKYKEYKNCFLQNDHNDKNNHMLNFIYNNYLKKRNHQNVKNESENGNYNNDHNDHQTCNNMNIFFSNEYLKSLSNFNEEDFRLIPLNDFFNKILLELFYKQREEIIHDDVIYSKNNIKSLSHVFNDNSPEQYRQKEKQQQVGNIIMCNSNSPEQYRQKEKQQQVDNIIMCDENLCETLIKDDEINENDDNKNPLENLCEDFKKDKDDIENIYNMHKLEYIEELFELIKEEDIKFQRVKLEFGYDNMNTSEILRKIFPCINEIIHKFEIIGHIAHLNFCDKLESCKKIIAEIILDKNKSIKTVINKKDILNNTHRTFNIELLAGENNYVTQLKENNIRVKLNYELIYWNSKLKKERDRIYNLVKDNSIIIDVFGGVGIFSLSLSKKSCLCFSNDINEHAYKYMNINISMNKNKNILTYNMDGREFLEKLFNLKIFSKNNNVLTLYINDQNQKNISLDVLNSKNHIITGNGKNKSKNKNENKNENKNENKNENKNENKNENKNENKNENKKDIQNNNMCEKENNISDRKCPYIHNNNNQRNITCDNNNNNNNMNVSGNNSIHQYTDMYEHKFKYQKIGEENMDNSKNEENHKIDINLNIYEDIHILMNLPQTALEFLNVFKKYKKEKNDELRNVFIHCYYFAKPEFFYEHAEKNILLHFNQLPKDIKITEIRKVSPSKLMYVVEFNLKDLL
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MTSTIELMKQFYGIQDDDSTEPPPDPTDIDGNAFEAEPYYKNLINNQSLPALITKDLTIKKEIHDLDGSLQFLVYDNYTKFLLAEETIRSMSDGLSNLSSKMQNVLDCLQKVQKQSAEIRTDLQPNREKIQRLVGINRLLERIEFISELPLKLRAHVDIKEYEAAVDIWLKAEKVLETQTHFESFIRIREECKGILEDVKVKVRGVMMSEDTTAKQAVACAATMIKLQMPVDSTLEDLVRFRLLLLVKKIEKPEALPTDLFELLDFFEKEVGESANELIENYAISLQKFVPIKGNRQFDKFMTAFRKELFAKINKAINDNALNTLSCEDFSNFITNLVNCIGKIAIPHQLEAYLSNLLQKYVKNRFGNIITATLTQIKKTETSSDLDQVFKDIISTFKRNLTSLLNEFEILANTNSEAKDHIIQETAKMFQGFFDEFDKIDPRFSLLTFGIAHQFGEKTIHLAFDLAARFDHESPLLNMQQMLCTEGHECAQRSLSRFVSMKRKMLSEMIAQGMAAQDWLEVKTPHDVSITSNLVIQEISLIWQQLDKIIQKVKEGSVASTHSSNFSRTTLSTFSTQSGPANQMPLFHGLRDDGMIQIDRLFTTLNHLHLRQEPNFESKSVLTAITFYTLKTMLEYIRKSTFNCAGFNQMQVDAYFMYMTLHDKLENPAMFSALIEEMLSSAADRTISPIPFKNAVLNDIYARSDSKPHQKDGI
The following text describes a protein:
Function:
Hydrolyzes the short-chain alpha-galactosaccharide raffinose.
Sequence:
MTSNLIKFDDQNKVFHLHNKQISYLLSIEDGGTLSHLYFGGAVKNYNNQLKYPRLDRGFSGNLPESLDRTFSRDSLPKEYSSAGEMDFHTPATIVRNPDGSNALFLAYKSYKIEDGKPDLKGLPHSWTKEDDEAQTLIVTLEDKVSKLEYDLLYTIYRDRPVIVRSVQVHNHGEEAVYLEKVASMQMDYVDKDFEVITLPGAHANERRVQRENIGQGIKVFSSYRGTSSHQMNPFMALVDHDTNEFMGEAYGFALAYSGNHKFEVERDQFGQIHVNTGINDYNFKWKLNPNEEFQTPEVLMVYSDQGLNKMSQAFHSLIHERIMRSKFKDQIRPVLVNNWEATYFDFNEDKLKTIVDKAKKLGLEMFVLDDGWFGHRDDDNSSLGDWKVYKKKFPNGLGHFADYVHEQGLKFGLWFEPEMISYESNLYKEHPDYLMHVPGRKPCPSRNQYVLELGRKEVRDNIFEQMVKILDSKKIDYIKWDMNRSLSDIYESDLPADQQGEAYHRYVLGYYDLLNKLVTRYPDILFEGCSGGGGRFDVGQAYYTPQIWASDNTDAIERLKIQYGTSLVYPQSMMTSHVSVSPNEQNGRITPFNTRGAVAMWGDLGYELDLTKMSDEESDQVVKQVTEYKKIREVTQFGTLYRLKASASNQCAWMMVDSNKNEAVVTVVNVMAHAQPYCTKTKLAGLDPDKRYKNLETDEVFGGDELMHLGFYDPIERGDFKAKMYHFKAIN
The following text describes a protein:
Function:
Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neural crest, cooperating with zic1 and mediating signals from both the wnt and fgf8 signaling pathways. Induction of hatching gland cell fate is independent of zic1.
Subcellular Localization:
Nucleus.
Sequence:
MTALPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRSSVPSGLVSSISRVLRIKFGKKEDDDDCDKKEEDGEKKAKHSIDGILGDKGNRTDEGSEVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPPTGMPALPPYQLPESPYSSLGQDVGSTVHRPQPLPPSSMHQGGLSAADTGSAYGARHSFSSYSDSFINPGGPSNHMNPVSNGLSPQVMSILSSPGGVGPQSQSDFSISPLHGGLETSNSLSASCSQRSDSIKSIDSLPTSQSYCAPTYSSTGYSMDPVTSYQYGQYGQTAVDYLAKNVSLSTQRRMKLGDHSAVLGLLPVETGQAY
The following text describes a protein:
Function:
Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA. Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. May play a role X inactivation in females.
Subcellular Localization:
Nucleus.
Sequence:
MSASEGMKFKFHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARLRSTGRKRKRRRLPGVDSVLKSLPVEEKDENDENSISSSSGDSSEEKDEEISEESDIEEKTEVKEEPELHRKREMEERTITIEIPEVLKKKLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMPHANMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQVQYKKVTSSKFFLPIKESATNTNRNQEELSPSPPLLNPSTPQSTESQPATGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSASPQPKRRQQDTSSSMPKLFLHLEKKTPVHSRSSSPAPLTPSKEGSTVFATFEGRRTNEINEVLSWKLVPDSYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MNISAADLYVPTIPGLSDDDAELFKMHAGHLPGVSNNTQTFFWLLQSQHNPSKDKLVVWLNGGPGCTSMDGLFLENGPFRANLNGTISYNKYSWNQNAHMLYVDQPVGTGYSYSTTDERFSSMKDISDNFIAFLENFYLVFPEYRRFELHIAGESFAGVYIPNFATDILQRNTVQKTKYRLKSIIVGNGWLDPIRQYNSYIPFAIQHDLLHGSYLDLAKKNWEICKKVLAEKSLVKSPDCEGILQQIINESKSTGKYCINLYDYRLRDQGPNQGCGLAWPTGIEHMVDYFNRDDVKVALHATGHKSGKWVECQRSVYKAIETQNTTASHVLLPDLLKHIEVSLFQGDTDIICNWLGLKEMVDVLEWNGAKGLGNVPQTPWLIDGRPAGWVSTARNLTFVLMYNASHMPSVDAPMASLDMVNRMMHVNFTQPLFESVLGSSDSLPATKAPIDGQSPPQPGPYLLAFGFLAAIIVFGIFIRMYCRRKPHRNSGHERLRQSESDPAHLEWAQVPTSEFIELQEP
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MTQSNPNEQSVELNRTSLYWGLLLIFVLAVLFSNYFFN
The following text describes a protein:
Function:
Seed storage protein.
Sequence:
MAKAFVFSLCLLLVFNGCLAARQSQLSPQNQCQLNQLQAREPDNRIQAEAGQIETWNFNQEDFQCAGVAASRITIQRNGLHLPSYSNAPQLIYIVQGRGVLGAVFSGCPETFEESQQSSQQGRQQEQEQERQQQQQGEQGRQQGQQEQQQERQGRQQGRQQQEEGRQQEQQQGQQGRPQQQQQFRQFDRHQKTRRIREGDVVAIPAGVAYWSYNDGDQELVAVNLFHVSSDHNQLDQNPRKFYLAGNPENEFNQQGQSQPRQQGEQGRPGQHQQPFGRPRQQEQQGSGNNVFSGFNTQLLAQALNVNEETARNLQGQNDNRNQIIRVRGNLDFVQPPRGRQEREHEERQQEQLQQERQQQGGQLMANGLEETFCSLRLKENIGNPERADIFSPRAGRISTLNSHNLPILRFLRLSAERGFFYRNGIYSPHWNVNAHSVVYVIRGNARVQVVNENGDAILDQEVQQGQLFIVPQNHGVIQQAGNQGFEYFAFKTEENAFINTLAGRTSFLRALPDEVLANAYQISREQARQLKYNRQETIALSSSQQRRAVV
The following text describes a protein:
Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Sequence:
MMRGGAEWVSCRGGRTLEFLSRRRGMSVVDWSGRPTMLGDGAGERVCLGNGSSAHDLGMCWKGARSSCRSSRMSIRSALCMENGGVMEEKPVLYGSELQGFADRVAACNGGRARSTEFLPFKIDNYTLGYIHHRLAQHLKRFSDVFSIEGDEDVSRIASGSSKLSYVTLDPSLSSPEKRTKAVAGVLETLKGEGLITGWRNELYPVVQNYGEPPFFLMERAAAKHFGIRSFGVHMNGYVNIDGEKHLWVARRSDTKSTYPGRLDHIVAGGQPEGISCKENVIKECDEEAGIPRDLAAKAVAVGAVSYDEIYGDCYSRDLLFCYDLELPLDFQPYNKDGEVQSFMRVPVSEVVNVIRDTEEYKPNCALVIIDFFIRHGYITPEQKGYIHLLQSLRSGDTS
The following text describes a protein:
Function:
Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases AGP1, BAP2, BAP3 and GNP1. Binding to promoters is facilitated by DAL81. Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes. May be involved in pre-tRNA splicing.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Sequence:
MISEQAPGWRGTVVGRMSAKVLSWLWSWAQQVSVGVGKNDDERADAAVAKAADTGPRRRRGTVSGLFPKRHNVDARLDLQASVVACSIDLSTLQSPISMTRTPEGGMEWKLNAGAHAGTPTQSNEEPLSPRSSSSAAQLKDEDGDELSKERFVCHYCDAEFRIRGYLTRHIKKHAVEKAYHCPFFNSHVPPETRCHTTGGFSRRDTYKTHLRSRHFIYPEGVKTQDRGKSCGHCAHCGKWFENTSTWIEKHIESGYCTGLPEGTILPAKSARKAGKLKMIKTSTGHSRFITTQQSVVEPKVLLNKEAIEAMQIVVNETNTAGQPALTKLSDNRIMLNSMNFKGEPRSKRAMRRGRRKRFSIGPAMAAHACANSASMMPSNAGATSATSCPIDAQLQPQMYMPHTGAAYTFTTPDETPLDEICLSLNPSPTDDASLVPVRSASSLSSHECQQPANNDMNKLLYPLISSNPVGIQDPYSIPLDFEQMGFAMAAEETPVLPAQKLVSEPQINVTLNRQMDPIKLGERQFRETQQYLNFYNYSFDTNL
The following text describes a protein:
Function:
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Sequence:
MAESAAVQVQAYAHHEQRKICASRAKYREGRRPRAVKVYTINLESRYLLVQGVPAIGVMKELIEQFALYGTIEEYNALDEYPAEEFTEVYLIKFQRIQSARVAKRKLDERSFFGSMLHVCYAPEFETVQETREKLQERRKFVARATSSKDWNAADKKQEIATICTQDVLGLHKSIADSSHISCRDPLHDRGDEKFCYTAPPLSHEHVYRPVSSYEVTSSNTVQGTVQQTIASNSYTWHSTRPNVPGISTARFMPRTTQLQERQKKRQQSNALALCGLAPGGQEVVIGPKLPEVSQLDMDNDSLNITANTIREKLKEVSCTAMAAAPGRTSDDAADRPPVKQRRRI
The following text describes a protein:
Function:
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSGTSVVSISADILRPPVLTAAQTFGDNENECRVRLVLTAQQVQEWNLLPQDIQQEILKNGQVRVETYSSSNTARKIFICTSSVSNLASSIPALIKVVTPTKEEDASLNINLAVSSLILGSKVLIHQNLIPSLFSVSNSTKLLYSASLLPRSSERLVTLETNEIDASVVIETLLKYILSRISFIPRVSVVPYIPDAAYGIYGSPSTFTQFNHMSSMVTPENPYGIPPIALTSAGGNPDPLRTTQVFPHSGPSIPLNIAATQVVSQKMSVPSSLLDQLYHAMPHKLMEISQNTNANITVEESDSNSNEKFISVVGTSEANQSALMQLYAALISLGRK
The following text describes a protein:
Function:
Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells. Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection.
Subcellular Localization:
Virion membrane. Note=Found as a pentameric complex at the surface of virion envelope.
Sequence:
MLRLLLRHHFHCLLLCAVWATPCLASPWSTLTANQNPSPPWSKLTYSKPHDAATFYCPFLYPSPPRSPLQFSGFQRVSTGPECRNETLYLLYNREGQTLVERSSTWVKKVIWYLSGRNQTILQRMPRTASKPSDGNVQISVEDAKIFGAHMVPKQTKLLRFVVNDGTRYQMCVMKLESWAHVFRDYSVSFQVRLTFTEANNQTYTFCTHPNLIV
The following text describes a protein:
Function:
Participates in both transcription termination and antitermination.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPQDILRYVDSLHRDKNIDPELLFQAIESALQSAAKKQYGEESDVIVSISRDNGAIAATLAGEPLGDDQIGRIGAQTAKQVIIQKVREAERDALMLEYRDQIGEIVSGMIGRADGGVATVNLGNVEAILPRSEQIPGESLHANERVRAIVFEVRPSGGNRVRVVLSRTRPQFVQRLFEQEIPELNDGVIAIKSISREPGYRSKVAVSSEDQQIDPISVCVGYRGSRIKAVREELAGEHIDVVRYDSDPEVLIPNALQPAEVDQVLLCDMIGRAIVLVQEDQLSLAIGRRGQNVRLASKLCGWDIEIMTNAELEEQIERAVGGFSQIPGITEEIAQALVEQGYLSYDDLSVIEPDLFMEMSGLSEADVDRIVETAEAKAEEAEQAAAEERRVRRDQERTDQNAPALAKAETPAAEESTEEATAETADAENAEAADGDQPAAEVATETSETTSTEEAPVEPADEVSGPVADEGETESEEPEPIAEAVESSEAEGNKQEG
The following text describes a protein:
Function:
Plays an important role in the elongation step of protein synthesis.
Sequence:
MSLGETACSYAALILHEDGISVTADKISTLLETAKVQVDTYWPTLFAKLAEKKNLGDLIANAAGGGAPVAVAAAPVAASGGGGAAAAAPAAEEKKKVSR
The following text describes a protein:
Function:
ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion.
Subcellular Localization:
Cytoplasm.
Domain:
The first ATP-binding region binds ATP with low affinity whereas the second ATP-binding region binds ATP with high affinity.
Sequence:
MSSAKKKPSLVTCPQCNAVVLTKDSLRHQDFCGKPVVESEIACAQNGTLRGFNVAVDKAEGFLPPDAVGWEKEHSILINQQTMESLGLLARQPVRIIHSSDSFIGIVWPCKEVALLKVSIISSRIARERMITLESCGRVEKLKSLSVTVKTSLTLNPALSGFLEAYLSHSYLQYNSSVDLKYLGQNVTVTPEEPIESKMSAMGIDDDKKRNSKVVSTAVGYKIQILNASAEGSTSDVLQTLPTDLSNIGGCFTAKQVLEDYVISPVRQKESPCSVLIWGLPGSGKTLLLKEVALVLSGSTTYIGSCEELMELNGVTTGNIVIVDVNELEKENTKANRALSFLLGDEKKCVILCVRSSETLDIGFRVRFPIEAEITVPTQDERLDILSKIGNIYNFPLELHLDVARHTHGFTGGDLCSLLKAAKFARGRTHLERVNDARKRIRPTGIRQFILEVPNVSWNDIGGNEELKLEIQQAVIWPQKHPEAFERFGIDPPAGILLYGPPGCSKTLIARALASEAKMNFLAVKGPELFSKWVGDSEKAIRDLFSRARQVAPTIVFFDEIDAVGSSRGSEKSSGVSDRVLAQLLTELDGLEKSSRVILLAATNRPDQLDSALLRPGRLDRAIYVGLPCEVTRRAILEMRTKKMKFDDTVRTIDKLVEKTSGYSGAELVAVCRTAAMFAMRESIDATIVQWTHFEQALAAVVSRTEAYLLEIYDDFKAGRASNA
The following text describes a protein:
Function:
Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles.
Subcellular Localization:
Vacuole.
Sequence:
MRPMPFLGVTCLWILSCALLLGGACSDGLLRINLSKKRLDKETLTAAKLARQETKLLRSDDGSRHSLGLSGDDIVPLDNYLDTQYFGEIGVGTPPQNFTVIFDTGSSNLWVPSSKCYFSIACYLHHKYKSTKSTTYKKNGETCTISYGSGSIAGFFSEDSVLVGELVVKNQKFIETTREASPTFIIGKFDGILGLGFPEISVGSAPPIWQSMQEQKLIEKDIFSFWLNRDPDASAGGELVFGGVDKKHYKGKHTYVPVTRKGYWQFDMGDLLIGGESTGFCAGGCAAIVDSGTSLLAGPTTIVAQVNHAIGAEGIISTECKEVVREYGEMILEMLVAQTRPQKVCSQIGLCVFDGSHSVSNQIESVVNKKEKRGSDLLCTACEMTVVWIQNQLRKNQTEELILQYANQLCERLPSPNGESTVDCHQISEMPDLAFTLANKTFTLTPEQYVVRLEQSGQTICISGFMAFDVPPPRGPLWILGDVFMGAYHTVFDFGESRIGFAKSA
The following text describes a protein:
Function:
Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.
Subcellular Localization:
Nucleus.
Sequence:
MQSKVTGNMPTQSLLMYMDGPEVIGSSLGSPMEMEDALSMKGTAVVPFRATQEKNVIQIEGYMPLDCMFCSQTFTHSEDLNKHVLMQHRPTLCEPAVLRVEAEYLSPLDKSQVRTEPPKEKNCKENEFSCEVCGQTFRVAFDVEIHMRTHKDSFTYGCNMCGRRFKEPWFLKNHMRTHNGKSGARSKLQQGLESSPATINEVVQVHAAESISSPYKICMVCGFLFPNKESLIEHRKVHTKKTAFGTSSAQTDSPQGGMPSSREDFLQLFNLRPKSHPETGKKPVRCIPQLDPFTTFQAWQLATKGKVAICQEVKESGQEGSTDNDDSSSEKELGETNKGSCAGLSQEKEKCKHSHGEAPSVDADPKLPSSKEKPTHCSECGKAFRTYHQLVLHSRVHKKDRRAGAESPTMSVDGRQPGTCSPDLAAPLDENGAVDRGEGGSEDGSEDGLPEGIHLDKNDDGGKIKHLTSSRECSYCGKFFRSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTSLRYHLERHHKEKQTDVAAEVKNDGKNQDTEDALLTADSAQTKNLKRFFDGAKDVTGSPPAKQLKEMPSVFQNVLGSAVLSPAHKDTQDFHKNAADDSADKVNKNPTPAYLDLLKKRSAVETQANNLICRTKADVTPPPDGSTTHNLEVSPKEKQTETAADCRYRPSVDCHEKPLNLSVGALHNCPAISLSKSLIPSITCPFCTFKTFYPEVLMMHQRLEHKYNPDVHKNCRNKSLLRSRRTGCPPALLGKDVPPLSSFCKPKPKSAFPAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAPSNLKSHRPQQNVGVQGAATRQQQSEMFPKTSVSPAPDKTKRPETKLKPLPVAPSQPTLGSSNINGSIDYPAKNDSPWAPPGRDYFCNRSASNTAAEFGEPLPKRLKSSVVALDVDQPGANYRRGYDLPKYHMVRGITSLLPQDCVYPSQALPPKPRFLSSSEVDSPNVLTVQKPYGGSGPLYTCVPAGSPASSSTLEGKRPVSYQHLSNSMAQKRNYENFIGNAHYRPNDKKT
The following text describes a protein:
Function:
Catalyzes the stereospecific reduction of the C-4 keto group of dTDP-4-dehydro-6-deoxy-D-glucose, leading to dTDP-D-fucopyranose. This is a step in the biosynthesis of D-fucofuranose, a component of E.coli O52 O antigen. Is more efficient using NADH than NADPH as cosubstrate.
Sequence:
MDARKNGVLITGGAGFIGKALITEMVERQIPLVSFDISDKPDSLPELSEYFNWYKFSYLESSQRIKELHEIVSRHNIKTVIHLATTMFPHESKKNIDKDCLENVYANVCFFKNLYENGCEKIIFASSGGTVYGKSDTPFSEDDALLPEISYGLSKVMTETYLRFIAKELNGKSISLRISNPYGEGQRIDGKQGVIPIFLNKISNDIPIDIIGSIESKRDYIYISDLVQAFMCSLEYEGHEDIFNIGSGESITLKKLIETIEFKLNKKAVIGFQDPIHTNANGIILDIKRAMAELGWRPTVVLDDGIDKLIKSIRCK
The following text describes a protein:
Function:
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression. Seems to negatively regulate SRC function in epithelial cells.
Subcellular Localization:
Cell projection, dendrite. Membrane.
Sequence:
MTATEAAMWRPHWIPAFQQGRKHPLEMQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLEDSKLEAVSDNNLELVNEILEDITPLISVDENVAELVGILKEPHFQSLLEAHDIVASKCYESPPSSPEMNIPSLNNQLLPVDAIRILGIHKRAGEPLGVTFRVENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGNNPKELQELLKNISGSVTLKILPSYRDTIAPQQVFVKCHFDYNPFNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSAGLIPSQFLEEKRKAFVRRDWDNSGPFCGTISNKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKIGSILDVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFENLQTAIEKLRTEPQWVPISWVY
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Sequence:
MTFQPTKTWLVFDDNALINKPTEAVNFPIDEQIETCIKKMIAYVDASYDGKAQEYDIIPGIGIAANQIGYWKQLFYIHLNDLNKEKKCLLINPKIIDQSENKAFLESGEGCLSVKKQHKGYVIRSEWITIKGYDWFEKKEITIKATGLFGMCLQHEFDHLQGRFFYQRINPLNPWFKKPEWKVINPTLKTSNG
The following text describes a protein:
Function:
Involved in the activation of early immune responses. Plays a role in pattern-triggered immunity (PTI) induced by pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Contributes to PTI in response to the bacterial pathogen Pseudomonas syringae pv maculicola strain ES4326. Contributes to PTI in response to the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000. Functions redundantly with PCRK2 in basal resistance against bacterial pathogens and in regulation of plant immunity. Functions together with PCRK2 downstream of the PAMP receptor FLS2. Contributes to the induction of SARD1 and CBP60G, which are transcriptional activator of ICS1, an enzyme involved in salicylate (SA) biosynthesis upon pathogen attack.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKCFLFSGGDKRGEQKTPISVSLTSIFSDREINRSGSEFNSRDVSGTSTESSMGRKNSYPPVSTRASNLREFSITDLKSATKNFSRSVMIGEGGFGCVFRGTVRNLEDSSVKIEVAVKQLGKRGLQGHKEWVTEVNFLGIVEHTNLVKLLGYCAEDDERGIQRLLVYEYMPNRSVEFHLSPRSLTVLTWDLRLRIAQDAARGLTYLHEEMEFQIIFRDFKSSNILLDEDWKAKLSDFGLARLGPSEGLTHVSTDVVGTMGYAAPEYIQTGRLTSKSDVWGYGVFLYELITGRRPVDRNRPKGEQKLLEWVRPYLSDTRKFKLILDPRLEGKYPIKSVQKLAVVANRCLVRNSKARPKMSEVLEMVNKIVEASSGNGSPQLVPLNSVKASRDARGKNNGGGGEGGWFGKLWNPKTIRAC
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLLNHLMFWMMVTEAAICLVLSLPFGQWLSHAVISFLMKNLGGKDSPANMVATVVLAVVSLLFLSDVTTVYKHHSSDEVLSDGMRIRLLTAQRDMYITGFCLFLFLLLRLVYLALATNLRLEKSLGAMKKQAEGAAAGYKSLLAENETFKQQVEKLHELLQGEDDADKKKKVDVLARLVQENADLENKVKSSAEKLLKAENEVATVKKQAEGQSSAFMKLMDEKNESDKQLETSKAQDEQLNRQREQIAKLTEERDSLKTQIQDYDFMFAEAKKKAE
The following text describes a protein:
Function:
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Sequence:
MSIENLHIADETEIPAGATVELHSRPERKARKALEGLGLKRVQGIQRVTLRRARNVLLVVSSPEVYKSPGSDCYIVFGEAKVEDPNSAAQLQAQAQLAASSQAAQQAHAHGGFKEGVPKSLEELMQDAPSTDSSAPAPSGEATDASASGDFKVSDEEIQLIVAQTGVDEAKAREAYISEKGDLINAIMKLQ