lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MLFPEEDEVHLKRWIVKRLENTSDADADVLADYVLALLRTNGEVEEVRRLCETEIPDFLKEDSSVFVRDVFQAIAYKSYLPDAPSVPKPAPPLPAFAAPPVAFPTIQPPGLSYDDVPGHPSQFPSYTGQSRKRSFDGRDETDGRDGHYGGRALKQPRRGAGFGPGGRGGRPDAGNGYLPAYPPFSENGQLPPGFLTGMSETLAALQQQMGLSAPPGYPAPAQGQRRRARCRDYETKGYCSRGNTCLFEHGDDSIYVPPPSTSFGTQFAAQPNPIEEYDPTNPGIFTLPPNLPPHQSIHQDGVHSSRSRGGRQQGPKRRPKAPFSADGPVFDRTKSTIVVENIPEENFDEEQVRGFFSQFGNILEVSMQPYKRLAIVKYDNWASANAAYKSPKVVFDNRFVKIFWYKEEDSSLPPSVPLGGSSEKHGEAGEDDYSAAVPEIDMEEFLRKQEEAQKAHEEKLRKLEEVERQREELEKRQQELLARQREEKAKLEAKLKSKLGGGSQQGDGSDDGSKPKSISEALRAQLAALEAEAKQLGLDPDAMDTSFSTSSWNTKGGYYGRGAFRGAYRARGFAPRGYRGAPFRGGARGNHHAAYAMYSLDNRPKKVTLTGVDFTDPEKDETLRQYLFGIGEFTNIQTTSSATDITFTDRKTAEKFFNGILLNGKEIPGIDGQVEVAWNPSSGPGSSSMASTPGSSSSMGAGATVQKPLSALSAAAMSFVPGGGPQAGVGGDGDSAMGGAGSVSGSDKDVNIVLERSGNHNGNGLHHNNQHYESHKQGDMDYDVADENQWEMS
The following text describes a protein:
Function:
Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII. May play a role in the immune response to viral infection.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
Possesses a PapD-like (PapD-L) domain similar to PapD domains involved in assembly and secretion of bacterial pilus components. The PapD-L domain can bind collagens and is probably involved in collagen assembly and secretion.
Sequence:
MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNESGYIFTLLFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGVLSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVAVERGNRTTIISSLPEFEKSSLSDQSSVTLASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHVVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPKVQPGVAMQEDMWDADWDLHQSLFKGWTGIKENSGHRLSAIFEVNTDLQKNIISKITAELSWPSILSSPRHLKFPLTNTNCSSEEEITLENPADVPVYVQFIPLALYSNPSVFVDKLVSRFNLSKVAKIDLRTLEFQVFRNSAHPLQSSTGFMEGLSRHLILNLILKPGEKKSVKVKFTPVHNRTVSSLIIVRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTDSLKLREPNFTLKRTFKVENTGQLQIHIETIEISGYSCEGYGFKVVNCQEFTLSANASRDIIILFTPDFTASRVIRELKFITTSGSEFVFILNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSSSRPSAGSHKQCGPSVHPHSSHSNRNSADVENVRAKNSSSTSSRTSAQAASSQSANKTSPLVLDSNTVTQGHTAGRKSKGAKQSQHGSQHHAHSPLEQHPQPPLPPPVPQPQEPQPERLSPAPLAHPSHPERASSARHSSEDSDITSLIEAMDKDFDHHDSPALEVFTEQPPSPLPKSKGKGKPLQRKVKPPKKQEEKEKKGKGKPQEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHESEMSQVKQKSKKLLNIKKEIPTDVKPSSLELPYTPPLESKQRRNLPSKIPLPTAMTSGSKSRNAQKTKGTSKLVDNRPPALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPTPASPSPPAAPCPFVARGSYSSIVNSSSSSDPKIKQPNGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSSNKTGFSSSLGISHAPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSKLGLSRSCNQASQRSWNEFNSGPSYLWESPATDPSPSWPASSGSPTHTATSVLGNTSGLWSTTPFSSSIWSSNLSSALPFTTPANTLASIGLMGTENSPAPHAPSTSSPADDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGLSNSSSFLLITCVLVLSFLIPELLASYGDQDDRFQLCAAKCINRDCKSTPSTKHLSLILRLMQWDCPQDCRYHCMHLQTQINQQNNEPIEQYYGKWPFVRILGMQEPASVVFSILNGLQHYKGWQKFTRGTKHSHYPYITLMRINGFLAVNSWVWSVIFHTRDFPFTERMDYFSAMASILFSLHLAVVRIFGLRSTRGFIRIILMIVCYCFFIFHIFYLTLFNFDYGYNMFASVIVGVSHTMLWWTWALANWRSRSSYAWKIIVVGLAVSMAMLLELMDFPPLFGLFDAHSLWHAATIPVIPYLWDFYLDDALYIIPIKIP
The following text describes a protein:
Function:
Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEFRYDFSDYKKSDFDPKAQAERVLISVHADSDVNEDKEVARKRLGYALKEVERQITDLIVHEETTLTKNVSSSLNAQSYLQDIEGKLEQLMLVYERIRSLVVIPSENLGPLHEAIVNLHSTYMTLYWLGEFFGIQAKLFPLFQGSINENEKLSRYYQASLLLQESDQLLSRFPLMKRQSSVSLLLKLNITNRSRIIKETSSYLLSQEDQLSFSVNSNGFTNACSVLYMLDKYLLEQDLTRLLSSRIQKAIIQFDSIFQLSPTTRRLLHNSTDPSAANSTIWSKFEDGWYQISKIGAQCVFWERSLQKANICNPDYPNLLEYFQMQPNFILDGATICIYFFKELAISISSKMQMLDRRDPILLRVFRSDFQRVTHIVEQAIARSSSEIVNKDTRECSIVMNSLRVLAPKNP
The following text describes a protein:
Function:
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Subcellular Localization:
Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.
Sequence:
MGAQFSKTAAKGEAAAEKPGEAVAASPSKANGQENGHVKVNGDASPAAAEAGKEEVQANGSAPAEETGKEEAASSEPASEKEAAEAESTEPASPAEGEASPKTEEGATPSSSSETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGAESEGGAAAAAEGGKEEAAAAAPEAAGGEEGKAAAEEASAAAAGSREAAKEEAGDSQEAKSDEAAPEKATGEEAPAAEEQQQQQQQEKAAEEAGAAATSEAGSGEQEAAPAEEPAAARQEAPSESSPEGPAEPAE
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
Subcellular Localization:
Cytoplasm, cytosol. Early endosome membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MAEAAEKETRSNEESTDESEEDESEEEPKLKYERLSNGVTEILQKDAASCMTVHEKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDESGEHMGVCSEDGKVQVFGLYSAEEFHETFDCPIKIVAVHPHFVRSHFKQFVTGGKKLLLYERGWMNRWKPSVLHEGEGNIRNVKWRGHLIAWANNMGVKILDMISKQRITNVPRDDISLRPDMYPCSLCWKDNLTLIIGWGNSVKICSVKERHASEMRDLPNRYVEIVFQFDTEFYISGLAPLCDQLVILSYVKEISEKTEVECCARPRLDIVQPLPESCEEISSDALTVRGFQENECRDYHLEYSEGESLFYIISPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQKTIKKHKILDIGLAYINHLVEKGEHDLAARKCQKILGKNTELWEFEVYKFKEIGQLKAISRYLPRRDPVLKPLIYEMVLHEFLESDYEGFATLIKEWPGDLYNNTIIVQAVVDHLKKDPQNRTLLRTLAELYTYDQRYGRALEIYLTLRHKDVFQLIHRHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIDRVVEELENRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELQDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPSDASKSFNVVVFHCRHMFHKECLPVSNTVSSVQFCNICSAKHRGPGSAILEMKK
The following text describes a protein:
Function:
Component of the cuticle of the pupa of fruit fly.
Sequence:
MYLLVNFIVALAVLQVQAGSSYIPDSDRNTRTLQNDLQVERDGKYRYAYETSNGISASQEGLGGVAVQGGSSYTSPEGEVISVNYVADEFGYHPVGAHIPQVPDYILRSLEYIRTHPYQIKDYYTGELKTVEHDAAAFNVYTRNIQDHTIPQSRPSTTPKTIYLTHPPTTTSRPLRQRRALPTH
The following text describes a protein:
Function:
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
Sequence:
MPTVIKLDGRREPFSHDKLRLSVIRAGLDVCVEVNGAVEVSVNRDVGTWELADMVQLELLRRAIDKPELALVAKAHLLGRIYKETFGKDFLKTKTGYRERAIARFKSLIEAGLLKPEAIEALSAFEPRPDFDRSLSYNALRLFTNGNYALRDQNFRLAETPSMAAWRVATAVARELERAKLYYDYITQLKIVPASPFWFNAWTRKEMFASCFTLEVEDCLSSITHPGRYCIYDALAYSGIIQQLGGGVGYDFSLLRPEGDVVRGSVGVASGPVSFMRLFDANVDVIKQGGKRRGAQMGTLHVWHPDIRKFIKAKTGELKDAHLQNFNISVFVDDTFMEKALGVDGDSKYKLINPRVFYDKTGKKAVEFVDVHKETQVPKEAVWGEVDARQLFGEIAHGAWDSGDPGLIFKSNLNASNPLLGEEIEISNYRFTYIWRSVNPCAETVQNPFEVCNLTHINLVKFVKENCAGGSFEEKLGCIDWEGLAQAARVGTRYLDDAIERSRTGIKIIDEMNSATRKNGLGIMGFAELLIKLGIPYASWEAVELINRIMGWIYVNALDESAELARERGPFKFFEKSVYARGEIPVLKFQDFVWRRWERIKRVYPRELQEAGDRLRDITMRTREWLRPYLERLADKVRGGVRNSVVLSIAPTGRTSILAGTTSGVEPVFALAFLRNVTVGTLIEYYEPGIEWLKARGYWTPQVRKVVEETGMLRDAPVPEAAKHLLATAMEIGWLWHVLMQASAQQWVDQGISKTINMPANAPQEDVYWAFAFAWAVGVKGITVYRDKSKSVQVIYTGLKQDIKKRLAETKIVVRPLALETSIEEVAEQAKLKALEEGKDPYCKTGECG
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVRHKKDGFSSRGGKGGHGRNAPRNNPRSSKGPRDNAGSGGEDTTANPHDPSTSSRPYRPPFKAACWDLGHCDPKRCSGKKLMKLGLMRELHLGQRHSGVIITPNGKRVVSPADKELMEQYGAAVVECSWARTKEVEWKKVGGKCERLLPYLVAANTVNYGKPFRLNCVEALAAAFAICGHLEWAEEILAPFSYGRAFLDINSKLFKIYSACKDEEEIKKAEEAWRERLEKEYTESREGESDDIWTTGNTNRRPAMDDSDEEDDDEDDEEDSDEEADSNDEDGSVDGIYLGTKPPPKQKQPAEEESEEEDKDPFAISDDSDDEAEMEAIRRKILASKSFANPEPPKKTVETIARPQGQYKPDSDAEPDSDNGEEDDEFDNIIAATPITDRIGLQKLEKERARATLTGTFSSASISAPRGGR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MATESCLSSSQISKVDNEKLVRPKVQLKSLLEDAGADKDVFTMKEVMFYLGKYIMSKELYDKQQQHIVHCGEDPLGAVLGVKSFSVKEPRALFALINRNLVTVKNPESQSTFSEPRSQSEPDRGPGDTDSDSRSSTSQQQRRRRRSSDPESSSAEDESRERRKRHKSDSFSLTFDDSLSWCVIGGLHRERGNSESSDANSNSDVGISRSEGSEESEDSDSDSDNFSVEFEVESINSDAYSENDVDSVPGENEIYEVTIFAEDEDSFDEDTEITEADYWKCPKCDQFNPPLPRHCKSCWTVRADWLPETHSNWENLSRNTRTNPEDTSVTTTPNTTFEKKLSKPSSPLPETDDGVDVPTPPLLRRGSSQEETPELERFNSLEACLPATCLEPCVICQSRPKNGCIVHGRTGHLMACYTCAKKLKNRNKLCPVCREPIQSVVLTYMS
The following text describes a protein:
Function:
Acts as an actin bundling protein. May have a role in the asymmetric organization and/or movement of cytoplasmic components. It has a role in somatic cells during the formation of adult bristles and hairs, and in the female germline during oogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNGQGCELGHSNGDIISQNQQKGWWTIGLINGQHKYMTAETFGFKLNANGASLKKKQLWTLEPSNTGESIIYLRSHLNKYLSVDQFGNVLCESDERDAGSRFQISISEDGSGRWALKNESRGYFLGGTPDKLVCTAKTPGASEFWTVHLAARPQVNLRSIGRKRFAHLSESQDEIHVDANIPWGEDTLFTLEFRAEEGGRYALHTCNNKYLNANGKLQVVCNEDCLFSAEYHGGHLALRDRQGQYLSPIGSKAVLKSRSSSVTRDELFSLEDSLPQASFIAGLNLRYVSVKQGVDVTANQDEVGENETFQLEYDWSAHRWALRTTQDRYWCLSAGGGIQATGNRRCADALFELIWHGDGSLSFRANNGKFLATKRSGHLFATSESIEEIAKFYFYLINRPILVLKCEQGFVGYRTPGNLKLECNKATYETILVERAQKGLVHLKAHSGKYWRIEGESISVDADAPSDGFFLELREPTRICIRSQQGKYLGATKNGAFKLLDDGTDSATQWEF
The following text describes a protein:
Function:
Has very low affinity for the DHPS substrate 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism.
Sequence:
MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNRTPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTEITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDPAMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAAAERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMALSNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEMVASIQGVRPPTRTVRGLA
The following text describes a protein:
Function:
Responsible for the proper stability and function of septins during cytokinesis. Required for the correct formation of the medial septin ring structure in mitosis and for the proper localization of endo-glucanases agn1 and eng1, which are needed for efficient cell separation. May act as a landmark for the localization of hydrolytic proteins to the medial region.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localizes to the medial ring at the cell cortex of dividing cells. Initially forms a single ring, which subsequently splits into two distinct rings as the septum forms, and disappears as cells separate. Requires septins for proper localization.
Sequence:
MLMTASQQDQHAKMYLADIHRALRIPSPIPSTDYECSDYASTIASISRESTMRNFNRSNISSTAPSFAESEDAEDGDSFPYDQTLSNSSSFDDHQSLLPFSTEVRRTPTYSVMNETDSSSTSVEDVNKENILSLNDSCLIKLSDDEASNKSSRSSTPRNSIKSNSSNQGHGDIPIPKKNPARSVCNSKLFNEDTLPAEFEEVSISPPVKLELPTHSHNSSDTSFTNSIVSSVSDMVGLGEGINSIASFGFSEDSSSFQDIKTPPRLSFADENRENCRTDIYRSDSIHEYEEPLTSSITSLDSPHVLDENAPIPLLPKVVSLPDPRFTNVLSAFDALTRTYLLRQNSKVVHATSQKQEMQTSRRVVNSCYMPESLSRNLSSSLQQTGGSGRLFVRLMEIRNLTIPLASGMTTRFTYTISGKHIQVPWNALHSTTKIENEYTFDESISSSIVCTLRAAYDPPKVRTRSTLGKVFSTNKRKSMTTDPVSEALHGFVSEDGTFGEVTINTDSVSRTALGRCQSMVLPIMNKWTVDPAAKDVKPLPRKVGELEIHVFFLPALPVSLKELPASIESAMYDLKLAEWDRTLLCDGYLCQQGGDCPYWRRRYFQLIGSKLVAFQQFSKVRRATIDLSEATHIVDDNHYSDEEELEGYLYFESGFRIIFSNGDYIDFYAETVGEKDEWMSTLRQHLGQCSMVHKNWTKSFLSLSF
The following text describes a protein:
Function:
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Sequence:
ASNSQTKALFHHKRLPDHGWTDVQIQRLLLELSVLDTNCEESVKWTGAGEREGRIYAPLVSQRHFGFGHGIGRSGDVMEAQPKAVGSSALLRLTLRLTLDAVRRGAGLNGTLGKGDSRNGPASFGTLLPVCTGMSMALVLSGLRDRARTLDSASIGTEHVNTERNIVLWSRIDQKSCYKSILSAGLKCVVLPTKKHPDTDEVSTDLEALKEALDSFGNSILAVLTTTSCFCPRVPDEVDQVAKMIMSAGVSHVVNHAYGLQCQTTNKLLNRACIIGRVDAIICSTDKNFLVPVGGALILSPDSNVIETISKNYPGRASSSPMVDLFITLLSMGLNGYKGILEERKRLTELFGQSLQRVATVFGETVLNCPRNTISFGMTLDNLATINGSDDELNSLITKFGSMLFTRCISGTRVVPRGSTKTISGHTFEGFGSSNDDYPYAYMTSACAVGMGEEEMNEFFVRLEKSWIDYRKKLEQ
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid; Reversible hydration of carbon dioxide.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGEGQGAASEWRGRGVGEGASGTGQEVAGRGGGQGERKISDEGQGEGGEARAGPASGRSRLPRSAVGAPSRYCSAIKRRPAGSLHPRRPSRCATPGPEASLLSRKMRMLLALLALLALSAARPSAAAESHWCYESQANSSKDTCLVPGKWGGNCQKDRQSPINIVTRKAKMDKKLGRFSFSGYDKKQTWTVQNNGHSVMMLLGNKASISGGGLPARYQATQLHLHWSNFLDKGSEHSLDGEHFAMEVHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGPQENKGFRPLVEALSNIPKPGESGLGRRAWGEEGIPPTKEGVGVGELGSQSAGEVGLLLPPSLTVSFFPTPEMNTTMAESSLLDLLPKEEKLRNYFRYLGSLTTPTCDEKVVWTVFQEPIQLHREQILAFSQKLYYDKDQKLNMTNNIRPLQRPGQRVVLRSGAPGQLLPWVLPALLGPTLARLLASFLR
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTIAAQGVPSGPSATKPLQVASLYVGDLDPAINEPQLVDIFKPYGTILNVRVCRDIITQRSLGYGYVNYDDVNSASKAMEELNFKRVGEKCIRIMWQQRDPALRYSGSGNIFVKNLKEEVDSRELSLIFKKFGEILSCKVMDDESGKSRGYGFVHFKDDDAAKAAIEKMNGDKEHADADKAALYVANFIRRNARLAALVANFTNVYIKQLLPTVDKDVIEKFFSKFGGITSAAICKDKNGRAFAFCNFEKHDDAVKAIEASHDQEVEGVTQPGEKLYVQRAQPRSERLIALRQKYMQCQSLGNNLYVRNFDAEFTEKDLNELFKEYGVIRSCRVMTDANGISRGFGFVSFENADQANAALREMNGRMLNGKPLVVNIAQRRDQRLTMLKLQLQQRLQMMMHHMHPPPFGMPGHPLQRRNARSGGRGNRPHPRQQQPQPQPEPQPPLATTVPPAAAHSVMFTAPSMGFSAVPRTPQASPAIAPDTPPLPPISAEDLQQMSVDEQRAALGDRLYIKVHELAPDHAPKITGMFLEMNPKEALALLSNPKLMHEKVTEALCVLKVHASSA
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
Sequence:
MDGVPCLRVPSCHAQELKSSLQSRGFLDRNLCIVKDVDGTVLLPILQSSLVHLDVQSPANSSIGEIVWRKGPVQPKKARGRTGGKLEKILEELLESHGEVLTEELRRDLPRSFQRHGDLILLGDSCFTLPVWKKMEDQLWSAVSSTLGVKRLAKMGRISQTGFRSPAVTMLLGEHSWVTHVDNGIRYDFDVTKCMFSAGNITEKLRVAALDCTGETVVDLYAGIGYFTLPYLVHAKASHVHACEWNPHAVEALQKNLQANGVSERCTIHQGDNRQLQLRDVADRVNLGLIPSSEEAWPVACRLLKKKTGGILHIHHNVTSPSQTAAADEAVQRVSGKKADKEAWQAWANHAANRIASLLRDLTSAAWLTNIQHIEHVKSYAPHVHHIVLDLECRPS
The following text describes a protein:
Function:
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDSYLLMWGLLTFIMVPGCQAELCDDDPPEITHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASRPGHCREPPPWENEATERIYHFVVGQTVYYQCVQGYRALHRGSAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQVQTEIAATMETFIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI
The following text describes a protein:
Function:
Putative oxygen sensor; modulates the activity of FixJ, a transcriptional activator of nitrogen fixation fixK gene. FixL probably acts as a kinase that phosphorylates FixJ.
Sequence:
MAPTRVTHPPDDGRGEHFRVRIEGFGVGTWDLDLKTWALDWSDTARTLLGIGQDQPASYDLFLSRLEPDDRERVESAIKRVSERGGGFDVSFRVAGTSNAGQWIRARAGLIRDEAGTARHLSGIFLDIDEEKQVEGALRTRETHLRSILHTIPDAMIVIDGHGIIQLFSTAAERLFGWSELEAIGQNVNILMPEPDRSRHDSYISRYRTTSDPHIIGIGRIVTGKRRDGTTFPMHLSIGEMQSGGEPYFTGFVRDLTEHQQTQARLQELQSELVHVSRLSAMGEMASALAHELNQPLAAISNYMKGSRRLLAGSSDPNTPKVESALDRAAEQALRAGQIIRRLRDFVARGESEKRVESLSKLIEEAGALGLAGAREQNVQLRFSLDPGADLVLADRVQIQQVLVNLFRNALEAMAQSQRRELVVTNTPAADDMIEVEVSDTGSGFQDDVIPNLFQTFFTTKDTGMGVGLSISRSIIEAHGGRMWAESNASGGATFRFTLPAADEN
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MQDNKNKFVNNKPECMMAASLLRRDKRATAAKLKADLNRTDNSTGLQQLQELLDVVLNPEKPASDTEALDWCKCLIAGGEGFEEFCKTVRSYDNATLCGLVWTANFVAYRCRTCGISPCMSLCAECFNNGDHTSHDFNMFRSQAGGACDCGDGNVMRDSGFCRRHRLKTGENVPSIPCDLLLMSEMVLPRFILFIIQYLRDGYVEQDSSTERDLQKVLQQLEPQISFLEELTKMGGAMRTVLTKILTNQQTFMDLSMGQEDNLYAKKNYEKYLSALKNSGLVSVEEKTLGAAEVTDGADGGAGAVVLMGSTVPGSPDESCKEEDQDGGQSVGQRKRVKLSCNTKDPCIIESLKHKCFLEELLFWTIKYEFPQKMVTFLLNMLPDQDYKITFTKTFVQHYAFIMKTLMKSHESDTMSNRIVHISVQLFSNEELARHMTEECQLLDIMVTVLLYMMESCLIKSELQDEENNRHVVVNCSEALLKNNTYWPLVSDFINILSHQSVAKKFLEDHSLLMLWMSFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLTHCKVKETQEYTRTVVRYCLETLQIWFDAIGFIDEPASNQVTFHLPLHRYYAMFLSRAVKCQGLDLDSLLPDQEMLMKIMVHPLQIQASLSEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLLTMASQHQNAVLDSEQERPMLEGALTFLVILTSLRIHLGMTDDEILRAEMVSQLCMNDRTHSALLDLIPENPNPKSGVVPGSCSFEDMLSAVADFKAPVFEPGGSMQQGMYTPKAEVWEKEFDPIMVVLRTVYRRDVQSAMDRYSAFLKQYGIHTDNPWPPYKERTPLHPCYKGLTRLLHCKTLHIVIFTLLYKIWMDHPNMSEHVLCMVLYLIELGLDNQLQENKEDEEPCIEEHCHDSWFPGTNLLSNLHHVINFVRVRVPETAPEVKREPPPSTSTEAASYGQNSRRLSGNWRENLREAQVFSLVAERRRKFQEIINRSNTEATQVVRPKSSSTRWVPPGTPPQLVTEILEIRESMLSLLIKLHQKMSSKQNSLSPSWLDDADTGRLAHGDGITAIERILSKAATRSCQIKRSIQDVCGKLFPPVLPKKSSPTDKKTMDKEERRQRARERQKKLLAEFASRQKSFMETAMDVESPEAEAAMDLGSSEVMESETHYDCVICGQSGPSTEDRPTGLVVLLQATSVLGHRCKSKEPKNLPTSDEEHIYSADTCGVAHDVRLTLMQQFFKDSSCLQSVSIGWDGGVYVQTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCRPGRAADAASWHTPTSKKTTVLVKEVDDLQERLALFPTESNLSKEMELVIKDIKNTTQKKYMDYGKNPGSPDNDFLFMYSVARTNLELELVHRGGNLCSGGASAAAKRSCLNQLFHVLAMHMRLYSIDSAYNPWTRLTQVAQNKEDGFEEERPEVPMLFRDAPSLLIIFVLTMPQPLRKEHFTCVVKMLYNLQFTQGLAAMSTKFSSEERQARVTSGALAKNTAVSEKSCEALLGHVISELSKENRVYNVNPEETAMLSSSVWSPQSVEVSLQQFCLPFLRLSCLLQHHLYGDSLTGCLEEEEFSSLAVCLGLLPSSPQPSNAMHSASCLEWPVSAFDLVSQWCAEVTGLSQMQAEQTLTLLVQDPQWAAPRLLQLPDNYNIIFQYYHRKACTVCKKVPKDPALCLVCGAFVCLKGVCCKQQGICECVLHSQHCGAAAGIFLLINASVIIIIRGHRFCLWGSIYLDAHGEEDRDLRRGKPLFLCEERYRVLEQQWVSHTFDHINKRWGPHYNGL
The following text describes a protein:
Function:
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MLGLVVCGGSRHAGAARRAGDPGSAAEAVAGLCRRRREHLCPMPRCSLYSLCLLLCVLLPLYNNASEPEGPAPDPAHYRERVKSMFYHAYNNYLENAFPYDELRPLTCDGQDTWGSFSLTLIDALDTLLILGNVTEFQRVVDVLQESVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLMHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARRALKGLWKSRSDIGLVGNHIDVVTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKELMSMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYQATGDPTLLELGRDAVESIEKISKVDCGFATITEAFLKERDKQAKWNGIPLLLQKLYVNSQPNSDFSKCQSILKEISPLLSMEAMVFVTEERKFSQESTFPNTYTFDLFGGVDLLVEILMRPTLTTQKKKQKISDDLTKDCLSILYNTCICTDGVTKRLAERNDFVLFLFTLMTNRKTFLQTATLIEDILGVKKEMIRLEDIPNLATLVSSFDQQQLANFCRILAVTISELDTGSDDKHTLLAKNAHQKKNLGPTCAEINQATLLNIPGFIERLCKLATRKVSESTGTSSFLQELEEWYTWLDNALVLDALMRVANEEPEHSSPDSSDESGVANTSSRTQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHKMIAEFKLIPGLNNLFDKLIWRKHSTSTLVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNSQELNELSAISLKANIPEVDAVVNTDRSLVCDGKRGLLTRLLQVMKKEPTESSFRFWQARAVESFLRGATSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNIDAFKRFNKYINTDEKFQVFLNQINSSLVDSNMLVRCITLSLDRFESQSDMKVVHVLSECRLLSYMYQMNNRTTFLFRLINIIHVQTLTQENVSCLNTSLVILMLARRKDKLPGYLNALQKMEYDEKYPGFILNNFHSLLRFWQQHYLHKDKDSTCLENSSCISFTYWKETVSILLSPDRTSPCALVSYIEEPYMDIDRNFTEE
The following text describes a protein:
Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity).
Subcellular Localization:
Cytoplasm. Cell membrane. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Perikaryon. Cell projection, dendrite. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner.
Domain:
The C2 domain 1 binds phospholipids in a calcium-independent manner and is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 binds phospholipids in a calcium-dependent manner and is necessary for calcium-mediated translocation and association to the plasma membrane. The linker region contributes to the calcium-dependent translocation and association to the plasma membrane. The VWFA domain is necessary for association with intracellular clathrin-coated vesicles in a calcium-dependent manner.
Sequence:
MSDPEMGWVPEPPAMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLAIEYFFEEKQPLQFHVFDAEDGATSPSSDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAHKLDNKDLFSKSDPFMEIYKTNGDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDIHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRTVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPKGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPSTPAMTPSPSP