lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQFSNDRYMADRDCFQKPTAGGILSPMDETSHRTERLKRSHTSKKMQGPDRGHSLAHTIANPQQLFSPKMSPIRAMGKSWGGSANGDQLVNRSDLFGTPSYRSPLDLVHTRPSAMVSQHGSTAPQQESEPSAVTGSTDVNKSLSEQDSLAKVKADGLLSFSFGSAPCHGSFSAVPNFDPGLSLSMGTSWSFNTAMGESVSGRVPNTIHNPNKAIVTVDAVTTQILVANDMACELFGYGRDQLVSMQLSRLLSGHRSSHLALTETHLDPASGELVSIAGKVVDAVDSTGLRIPISLWMKRLQWQDQPRCVVVMEPVERRVAHVQFNSQGLLVDCDEEFCSLLGYENPSDLQGCQILNLLPGMSIPIPSTLKNKDVHKQRITGSTKDGNSFPLSLLIEQSDAAGHPDNTDSNESDRSPVYSGTVWVFTNISGMITLQEDGTIYSVNHYFALALFGYPQADLLGKPVTNLIPDFERHVDLIDTSSMPLPPFDESSEDELSMPDLISTGKSDTQKILDLQNDSEHQKPQPDRSSESHTIEKAVPLITDQSEGSQEPEQKADNISAVQRIDSTPVQEADSSCSTQTVDSNAADHVADKLSSMTIDSSTAVQETDSTSIATVENNSLQKKGIDERVRVDNVESTENQIDSMEGSNTIEKVNDGSTVVKNNNSKPSSPVTESTSVSQKADDNPDRMDSNQLTQENESSNAVCGDIKQSSGSHGKDSNSPRVQTAESSENQRTESTVITRTDDLTLQSPDGHQDVASIKAVRSSTPNHLEPGNASTNQWISSSLDMQEGSYVGYCRHRNGAKLGILFQMKRVVLDNGKELWCMWVSRDPGDEIPGSQSHSHANFTLGSNLTSSLEASAVSLDTKALPADPEQESAAAGHYDQRYRTHQCIGKGAFGFVKVAERRADGEQVVVKFIRKAKVLEESWVEDSSLGRVPLEISLLAKLEHPNIVTMLEAFENEEFFQVVMEKHGGGMDLFEFIDRRPHLDEPLASYIFRQLADATDYLHRQGILHRDIKDENIILSENFWIKLIDFGSAAYMEENKMFATFCGTMEYCSPEVLMGNWYRGPELEMWSIGITLYTLIFGENPFYDVEETIRAVLSPPFEVSPELIDLISWLLHPSPTYRCTMDQLVDHDWLHQPCNPQDYSWNHVLPDEEGHPEEGVVPLGSDSESEVEELQQHLQKCLNDKGMNMSI
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MEHALDILMRDTKYKLLFRWDRAHCTEMGFNDGNEDHIFFVKELRKLWEKKDPSLPWEVGEYDESNTLLVENYPHRALLNPPHTTIFPYPYDWNTEDNALGPEGDLRIYLERLAASQNVQKFVSENPFDQHLVHASENHPEISTEVYLKFFHKYSYKRKAGDSMDAQRKNSLEPKVNSSSPLAAQTSLEPETSTVTALVGQPLSEPDLSNTGLGAQTSTEPQTNAGTTTDYQQDWPFIKQSLIWATIDSLVSCLTPPQKPHFSPLKNTKELHREGLAIAHMLTCYNLVRSLPNIKLNDPVDIINDNLEVLVDLEAHGFDVDLIRCRLNELLSLKSKAGQHEDTLKELEKRSYEKLVIEKETDQLKVEMEKMQEKMMQAETMQKVKEEEIARLQSNLHPDFTQINDWELAFGKLAATPL
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MQSLIWASAIPLYITHSSSTIPYLINVPRVSYLALLFPRLTSFFGENVSSFSYEGILLKNLPVGLLCDLYQPELPWRIELGDGPLFDIHDTFINSVKEADFMRNGNAKGIMSMSKEHSTQLWNSVQDNDFSTYHKISTILLNPATALKHIPLRIYLPSSSTPSSTPHPGSSGSSKAPSTASPPSPLFTFKTIQTLIQPQTTSREPQTLGGALNSVLPTLFPSKRDAILAEVILHGATVPFKAVLEDLMREASYADGWLNVCVVMLN
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MCNVEDQDLLPPSKAKNASRTCIKCKEVAQIVLRADNCYCRSCFIAYFTHKFRATIGKSKLIRSNEKVLLAFSGGPRSSAMLYLVHEGLSENIHKKLRFLPGVVFIDDGAILQLSENERRNYLEFIRTTVSKTGFPLFCESLGKIFPTNQDTNIQSNLLSSDLSNTTRSDATSSSNFDLDTLIKRFKNDELKIVQVFEKLPNSTAKEDMLHILRKKLIQQIAEANGYTKVMFADCGTRLAVKILSDIAQGRGSSVAHDVTFADERNQAVTLVRPMREFLTKEVANYLTLKSIDYRTRLSLTTMKPVKSSIERLTENFVTDLQASFPSTVNTICRTGDKLSVGDTSKIDADAICPLCDSRIDTNNSLEGKTTSKTTSKICQNTADSCCGEGDGSCNRIARINLTAKEIEDRLCYGCRLIFHSNNWEMDDLPQFLIDAIEKQLRRKRLKEEIEEFLLD
The following text describes a protein:
Function:
Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between Piezo2 and the cytoskeleton.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSESSASALQLGRPSRQPAVHPENLSLDASCFSSPPVNFLQELPSYRSIARRRTTVHSRDKQSGTLLKSTDSYSSQLEDRIAENLSSQSLRNYALNISEKRRLRDIQETQMKYLSEWDQWKRYSSKSWKRFLEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMLVLLPILLTKYKITNSSFVLIPFKDTDIQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETSLFYGHYTIDGVKFQNFTYDLPLAYLISTIAYLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMADLKHSSLRYELRADLEEERIRQKIAERTSEETIRIYSLRLFLNCIVLAVLGACFYAIYVATVFSQEHMKKEIDKMVFGENLLILYLPSIVITLANFITPMIFAKIIRYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSCDDDTCDLCGYNQKLYPCWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCSSWKLIQCWGQQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNFFFLLVLLIGLCLAIIPLTISISRIPSSKACGPFTNFNTTWEVIPKTVSTFPSSLQSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLSLESRDKRYLIQKLTEAQRDTRN
The following text describes a protein:
Function:
Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events.
Miscellaneous:
MISCELLANEOUS: Present with 486 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDTSKKDTTRSPSHSNSSSPSSSSLSSSSSKEKKRPKRLSSQNVNYDLKRRKIITSEGIERSFKNEHSNLAVEDNIPEEEPKELLEKDSKGNIIKLNEPSTISEDSKVSVTGLPLNKGPSEKIKRESLWNYRKNLGGQSNNSEMTLVPSKRFTQVPKNFQDLNRNDLKTFLTENMTEESNIRSTIGWNGDIINRTRDREPESDRDNKKLSNIRTKIILSTNATYDSKSKLFGQNSIKSTSNASEKIFRDKNNSTIDFENEDFCSACNQSGSFLCCDTCPKSFHFLCLDPPIDPNNLPKGDWHCNECKFKIFINNSMATLKKIESNFIKQNNNVKIFAKLLFNIDSHNPKQFQLPNYIKETFPAVKTGSRGQYSDENDKIPLTDRQLFNTSYGQSITKLDSYNPDTHIDSNSGKFLICYKCNQTRLGSWSHPENSRLIMTCDYCQTPWHLDCVPRASFKNLGSKWKCPLHSPTKVYKKIHHCQEDNSVNYKVWKKQRLINKKNQLYYEPLQKIGYQNNGNIQIIPTTSHTDYDFNQDFKITQIDENSIKYDFFDKIYKSKMVQKRKLFQFQESLIDKLVSNGSQNGNSEDNMVKDIASLIYFQVSNNDKSSNNKSASKSNNLRKLWDLKELTNVVVPNELDSIQFNDFSSDEIKHLLYLKKIIESKPKEELLKFLNIENPENQSE
The following text describes a protein:
Function:
Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton.
Sequence:
MKDSGDSKDQQLMVALRVRPISVSELEEGATLIAHKVDEQMVVLMDPMEDPDDILRAHRSREKSYLFDVAFDFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDHEPGIYVRTLNDLFRAIEETSNDMEYEVSMSYLEIYNEMIRDLLNPALGYLELREDSKGVIQVAGITEVSTINAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQVAVRQRNRVKNILQEVRQGRLFMIDLAGSERASQTQNRGQRMKEGAHINRSLLALGNCINALSDKGGNKYINYRDSKLTRLLKDSLGGNSRTVMIAHISPASTAFEESRNTLTYAGRAKNIRTRVKQNLLNVSYHIAQYTSIIADLRGEIQRLKCKIDQQAGRGQARGKLDRGDIRHIQAEVQLHSGQEEQAEMGQLREQLISAFHEQMDVRRRLLELENQAMEVQIDTSRHLLTIASWEHEKSRRALKWREERRKESYTKEDSEKDSDTGDEPDNLEPPEVASARENIAALVGEQKKLRKEKLALEQRCRELRARGRRLEETLPRRIGSEEQREVLSLLCRVHELEVENTEMQSHALLRDSALRHRREAVRRLEQHRSLCDEIIQGQRQIIDDYNLEIPRHLEELYEVYLRELEEGSLERATIMDRVASRALQDSSLPKITPAGTTLTPDSDLESVKTLSSEAQCPQNNTLPPLGTDSDSYHMFKASPRAWQVKSSSVPTPPPIQVGSLVTQEAPPQDSLGSQINSSPDSSENLSEILLSHKERKEILTRTKCISVKAAQRRSRALGTEGRHLLAPATERSSLSLHSLSEADDVRPPGPLACKRPPSPTLQHAISEDNLSSSTGEGPARAVGPRGDGSGPWVRGQKKCLSKKREESLEAKRRKRRSRSFEVTGQGLSRSKTHLLGPRPSEGVSDRRMPACGRPSPGVRHLGKVSLPLAKVKFPPNQNTGSGNPSPLLVPSNQAGVSRRATRGPNLPHGSSTFGKDGRLQHN
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPPSKGLNGKLEKPKHALQAIVLSDSYNYRFRPLTLDKPRCLLPLANTPLIEYTFEFLALAGVQEVYVFCCAHAGQIREYIEKSKWNLPSSPFSVNTIVSRESLSVGDALRELDSKQLITSDFILVSGDVVSNVPLNEVLKEHRKRREDDKNAIMTMVVREASPFHRTRARTESSVFVIDKKTSQCVHYQANERGKHYVSMDPEIFNEHEELEVRNDLIDCQIDICSNDVPALFTENFDYQDIRKDFVYGVLTSDLLGKKIHCHVAKENYAARVRSLQTYDAISKDVLSRWVYPFVPDSNLLNQTFSYQRHQIYKEEDVVLARSCIIKARTLIGAYTKVGDASVVANTIIGRNCTIGSNCSIDSAFLWEDVVIGDNCRIGKAILANSVKIGNNCSIEDGAIVAAGVVIGDNTIIEKNKRLTTFESHSQGTLNDPSLVGIGGRGQEYHAEEDSDDEGEFMEASGLIESTNELHLSDSESSETSSSSEEDMEFIPFSARRDSANTINSEDFDEGDFNKEAQQSLERAFEENHQIDIAALELNTLRMAMNANYHEVRSAIVLALLRRIMHLDVSPKEALAKVMTRWGPLLAKLTFSHEEQVDNVLTLQKYCVRLSMTRHFLQLLGYFYQLEIAEENAIQEWYSDPRSSEGELAALRDAGGKQFVDWLNTAESESESEEGSE
The following text describes a protein:
Function:
Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDPEYSELFERLNKQLDNVEDVLKPLKDAESIFELAEGKSELEQAKLYITMSYAINSTLYSFYKLNGIDASERPVMQELQRVKNYISKIQQAEKNVNPKTEAVNTSNAAISSSSSNRPKVAKDAATRIIKHHT
The following text describes a protein:
Function:
Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.
Sequence:
MPRVPRRPSDEARRGAYKPPGVDAARSRRRREDRFLALRRRNRDTGLFKRRREEPSLTPAPVVPPSDAAADATAPPPPPEPSSPPSSPPPADALRAAAEAELEGLSEMVDKVWSDDTATQLEATVQFRKLLSDGKNSTMIKIIRADVLPRFAEFLSRQRPPQLQMEAAWVLTNIAASDYTLLVAECGAVPRLVELLESPDANIRHQAIWALGNIAADMPSCRETVLDHGAVTPLLAQFKEGMKVSVLRTATWALSNLCFGKLPAEVQVKPILEIISLLIHSADEKILADACWALYYICDGVEGGIQDALDAGVCPQLIKLLMHASANILLPVITSLARISAGDDTQVQVIVEQGILPCLAQLLARNYPKIIKKQACLIVSNITGGSKDQIQAVIDADVMNHVIVLLKTSETDLKKEAAWAISNAASGGSSNQIQYLVSRGCLEPLCNVLKYQDVDLVYTCLEGLQNILEEGEIGKQGNESTTNPYAQFILENGGLDNLEDLQDFDNDAVYKLAMKLLEKYWDEEVSDDANLTASKDGPAENVETVPEEATQPPVPAPSSEGIE
The following text describes a protein:
Function:
Produces green light with a wavelength of 562 nm.
Subcellular Localization:
Peroxisome.
Sequence:
MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVNITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMNISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKSKL
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Recognizes FZO1 and regulates the amount of FZO1. Regulatory factor for the mitochondrial fusion machinery. Required for mitochondrial DNA maintenance.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MTKRRNLFMVGSSFTIDHLPPEIWLCISKLVGTSDLHNLCLINRRLYLTITSDEIWKRRCYDRWINRESLDILTGNDYDSIPVSQWYSYYLRRAKWENKIFCLLWGLTEETNPQHFREKYLHILQFRHYKLATFLHRIIKQGYIPDKRPLDLITYANYLLKNVRHKYVFPLFYPTNAAELKNLNNMASRDAEMIYLRLSAIDTSFDDLLDAREFILNGICSDLLQKYKKIEEFLKLRPVTRVSKLISISTDYLDCFTQPHDSVGQTNDRATGRELHREDFMLLRVYSREGRGYKTIILAIIQAITKRYNVDSYLARDHLVVSEPDFPDGRAFVTVNEDFQPYIFDKEDLLSVWSNNFHNAENFESTVLPALLEPISIQHLLTEFFRELLRCKPRPFEGYPNRAHGLRDMFPYGKVEVPRDVTMYFAFIYDLFDGMFESGMTSLRGQMLRDLLNYVNANNFGDLNIIIGQNALKEPNDCWSNKRDYVLLDDNNKIGYFYTDIETEDTLCALNQYEVDGKVFITTIDILGDIRVRLAEGLTPFQGDNDKLWESFSSVVPRTDWGLFFKGYDKERRRMQLNPYIEEKLSNLANDEQPLHNL
The following text describes a protein:
Function:
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity.
Miscellaneous:
MISCELLANEOUS: Synpo deficient mice develop normally, but they lack the spine apparatuses. Adult mice have an impairment of spatial learning in the radial arm maze test.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell junction, tight junction. Perikaryon. Cell projection, dendritic spine. Postsynaptic density. Synapse. Cytoplasm, cytosol. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses.
Sequence:
MLGAHFPPPPLGASEGRAAPCTFQIPDGSYRCLALEAEESSSEDGLQGEVRLVDLEEEGTSQSRANHGTPPLSRAPAIIQPSSCHREARGGFQRSDRPSHDWDVVQARKVMTASGSSSPVPRVAQKPALGRSTSFTENDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESRGQRSPKLNQEALQTGRPLSPIGHAPGPSVKPTSPSKPGSPKHPSPQSPSRGVAGHIMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQSRETQQSSPNPPDTEVPSPAADINQNPSSPNATLTTLASSSHHSQPTADINQNPPAAITPVPQNSSQAQCSPNGTLDSKPGTLCADDGQSPVPAEEVRSSILLIDKVSAPPSAASTFSREATPLSSSGPPAADLMSSSLLIDMQPSTLVAPAEQEVPGHVAVTTPTKVYSEVHLTLAKPASVVNRTARPFGIQSPGTSQIEQSPMMGRRQFGEKAWAPPASSMADRSPQPQRHIMSRSPMVERRLLGQRSPVLERRPLGNFTPPPTYAETLSTAPVASRVRSPPSYSTLYPSSDPKPSHLKGQVAPANKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDHGEVGMEEEPFALGAEASNFQQEPIARDRASPAAAEEAVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYTTNAPGGFRVASLSPARTPPASLYHGYLPENGVLRPEPTKQQPYQMRPSLYALSPVKEPAKASSRATSSRTPSRTVSPRAASPAKPSSLDLVPNLPRAGLPPSPALPRPSRSSPGLYTAPVQDSLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK
The following text describes a protein:
Function:
Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.
Sequence:
MYSGIALCVAALAALAAAGPAAVRQERSALSFRWCVPQELVDDCGRLTAAAGVPVGCVGGIDRLDCLRKVQNREADYLMADPEDVYVASHFDNADFAVFAELRTAEEPTAQFRYEGIMLVRAADNFRALADLRGKRSCHTGFGRNVGYKIPVTRLQRAGVLKLPQGDGTLSPVERELAGLSELFSASCLPGSYSSDGGFDRLLKERYGNLCQRCAQPDRCAKDDRYAGYEGAIRCLVENGGDVAFSKTINVRKYFGLPVTSGGVPAGPAVNPNARPEDFVYLCEDGTTRPIAGGDGQPVCSWAQRPWQVLLANGDLSGARLQELQSVGQKLHRYWTAPEQESDRATAQRLWIDRNAPLVARNETLAPRDYLARANYAEVIEREGRYGNVLRLCVVSEPERQKCELMRQAAYSRDIRPALSCVLKTHEACVAAVRDGTDADVVVLRAPNAQLEPLLWETFGDVMVAIADKTISRERLQTGPVALDLADERAVAAFGQLVTRLPSLKSVDASAPEAAGAPIRIVNSNALPQGEAADQKVLVCDDFTFQPLANVAMCHLRSNDERGPAAAIYVRRQVDEAVKDSVVHAFTALSDTFGHGQAREQVFRLFGPFRLRSGEQQLDLIFHHYAVALSAAKRS
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MNPTFLEFIGANQRSSCGYCKNDRGERTPARSAKKNAETGEEDLTNGLEEELEVSSESSVTTGGAWAHSMTVNDYSGLLDVGWRRSGRYLYKPDNRVTCCPQYTIRLDVTKFKMSRSQKRAMRQMNEFLATGKRPVCGIKEEDAPVEMNLKGSGSQSEQSKKNLKSHEVSTKKMKDADRPVLTKKEIRNKKFEEKCRQKNLDPDVVRTERRQKDAARQRTIQSYIDEARPDWKHKLEVKLVSLGGDEFGTRDNESFELYKNYQHTIHKDEDCRLAGFRRFLCDSPLKKEQRGGIELGSFHLWFLLDDKLIAVCVVDILPKCFSAKYMYYNPEYSFLSLGTYTALREIEQTQRLHAIYSNLKYYYMGYYIHSCPKMRYKAKFRPSDLLCDQSFRWVDFNSCRDLLDGSTCSNGFSEFCPGAPRPASPVVDTLLVFSNGSITTLSDALTEIPEAAENEQFLANVRDLAHLVGPDLSRVVYYFNELNS
The following text describes a protein:
Function:
Promotes the association of the U4/U6.U5 tri-snRNP particle with pre-spliceosomes to form the mature spliceosomal complex.
Miscellaneous:
MISCELLANEOUS: Present with 1260 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
Interacts with the snRNP via the Nop domain; The coiled coil domain is formed by two non-contiguous helices.
Sequence:
MSSEEDYFDELEYDLADEVNEEKEDIQTKKLTTVNCQTEKFNPFEILPESIELFRTLALISPDRLSLSETAQILPKIVDLKRILQQQEIDFIKLLPFFNEIIPLIKSNIKLMHNFLISLYSRRFPELSSLIPSPLQYSKVISILENENYSKNESDELFFHLENKAKLTREQILVLTMSMKTSFKNKEPLDIKTRTQILEANSILENLWKLQEDIGQYIASKISIIAPNVCFLVGPEIAAQLIAHAGGVLEFSRIPSCNIASIGKNKHLSHELHTLESGVRQEGYLFASDMIQKFPVSVHKQMLRMLCAKVSLAARVDAGQKNGDRNTVLAHKWKAELSKKARKLSEAPSISETKALPIPEDQPKKKRAGRKFRKYKEKFRLSHVRQLQNRMEFGKQEQTVLDSYGEEVGLGMSNTSLQQAVGATSGSRRSAGNQAKLTKVMKHRISEANQQADEFLISLGHNTEQPNLSPEMVQMHKKQHTNPEEETNWFSGHG
The following text describes a protein:
Function:
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation.
Miscellaneous:
MISCELLANEOUS: Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.
Subcellular Localization:
Nucleus.
Domain:
Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure.
Sequence:
MVGVPGAAAFQLGCEKRVPAMPGSPVEVKIQSRSSPPIMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERRDENNFERDTVPPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRERHHNLSLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRFNENTELRKTGTELVSRQHSPGSTDSLSNDSQREFTSRPATGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQSLHGHSPHSQSRPLLPGGRGSARSADCSVPSPALDKTSATTSRSSTPASVTAIDANGL
The following text describes a protein:
Function:
Catalyzes dephosphorylation of 5''-phosphoribostamycin to generate ribostamycinin the biosynthetic pathway of butirosin.
Sequence:
MRLILIRHAQARCNILEDDALMDAYDPHCELTEAGIGQAVKLRDEYPVSLTPSVIYSSPLKRARETAGIFRGRYPSVPFVEDERLSELKAPESFIPPITQGQWDLYLEQRIRSPHLEIVKGLESLDVQRERIERFYKDLFRKYAEEACNIVIFTHAFSIQLSILFFLGLGNEQLLQWQIKASNTAMHIIHYDPTSGSFLLESLNNRSHLQTTG
The following text describes a protein:
Function:
Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate.
Sequence:
MQQLASFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMTFIERAAMLKAVAKHLLSEKERFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPDDTLWPEDELIPLSKEGGFAARHLLTSKSGVAVHINAFNFPCWGMLEKLAPTWLGGMPAIIKPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSAATGQMLRVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRRIIVPQALVNAVSDALVARLQKVVVGDPAQEGVKMGALVNAEQRADVQEKVNILLAAGCEIRLGGQADLSAAGAFFPPTLLYCPQPDETPAVHATEAFGPVATLMPAQNQRHALQLACAGGGSLAGTLVTADPQIARQFIADAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGGGEELGGLRAVKHYMQRTAVQGSPTMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSLLTPRRTMTEADIVNFACLSGDHFYAHMDKIAAAESIFGERVVHGYFVLSAAAGLFVDAGVGPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRSAEEKPTGVVEWAVEVFNQHQTPVALYSILTLVARQHGDFVD
The following text describes a protein:
Function:
Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNSASKLFVVLASPANQRNMATLKDLKIRLGTVKTISKLTKTLHMVASSKLRSAEKKAEESGPYSVGPQKVLGVVETADAFNTATEPIEDRSNKQLLIAITTDTGMCGPVNHQIIKTIKALLKDDAKQEILVSTTGLKGVAPIVADFPNQFLINGRDFGKADYSFPEVLLFLNEIISKVPNYDSALVVYNKFKNALSYSVDRQFIPGFNLLELNRDKFYEYTTSEDRAATMKDLSEFYLASSLWTGLYQNRASEMAARMVAMDNASKNGESISQALGLQYNRARQAMITSELIEIVSGASAIESSD
The following text describes a protein:
Function:
Involved in D-xylose catabolism.
Subcellular Localization:
Cytoplasm.
Sequence:
MNYQPTPEDRFTFGLWTVGWQGRDPFGDATRRALDPVESVRRLAELGAHGVTFHDDDLIPFGSSDSEREEHVKRFRQALDDTGMKVPMATTNLFTHPVFKDGGFTANDRDVRRYALRKTIRNIDLAVELGAETYVAWGGREGAESGGAKDVRDALDRMKEAFDLLGEYVTSQGYDIRFAIEPKPNEPRGDILLPTVGHALAFIERLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQNGIKYDQDLRFGAGDLRAAFWLVDLLESAGYSGPRHFDFKPPRTEDFDGVWASAAGCMRNYLILKERAAAFRADPEVQEALRASRLDELARPTAADGLQALLDDRSAFEEFDVDAAAARGMAFERLDQLAMDHLLGARG
The following text describes a protein:
Function:
Required for normal pollen grain germination and pollen tube growth. May not be required for pollen development and female gametophytic function.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRSHQAGRKLPLLQLLGCVAVFSVFVFTIQSSFFADNNRKLDLQPEDIQILSDFQSSVQQCVANRGLGLSAHIIDHCNLILKFPEGTNSTWYNAQFKVFEALEFKYNVCEAVLLWEQYRNMTTVLTREYLDVRPDGWLDYAAMRIAQLGADKCYNRTLCEEHLNVILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEKYAKYVGVKRDFRLVVRGAARNMIKILNGSDNEVLIIKSVTHRDFNEMIKRIPNPVYLFQGIVLRRGAKGTGMKSIELALSMCDIVDIYGFTVDPGYTEWTRYFSTPRKGHNPLQGRAYYQLLECLGVIRIHSPMRSERKEDWSSVPSREMISRAHTAALRLQRSQQPTSSKRDGSGQFGNCKVWGDADPTKGPVSGSPDMSETRKKSNYKKWEVMPFRSLRKEARDHYIQMKGVSQYKMDGNKLDDLVCVRHPLKLDT