lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Recycles between endoplasmic reticulum and Golgi. Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles (By similarity).
Sequence:
MLRSRVPANIRAFDAFPKFSKEYRRQSSSRGGFFTILLSVLIVVLVFSQCVQYIRGIREQELFIYDSVSELMDLNIDITIAMPCSNLRIDVVDRTKDLVLATEALTLEEAFIKDMPTSSTIYKNDRYAGLRWARTEKFRKKNNAEPGSGTACRIYGQLVVNRVNGQLHITAPGWGYGRSNIPFHSLNFTHYIEELSFGEYYPALVNALDGHYGHANDHPFAFQYYLSVLPTSYKSSFRSFETNQYSLTENSVVRQLGFGSLPPGIFIDYDLEPLAVRVVDKHPNVASTLLRILAISGGLITVASWIERVYSSRAHRSTSEADMLGLLGKSETE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAARKDLLPIVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSSQFASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKDYFDGEVIIVPPVEDEKGKISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARGRTIGYPTANLVLLDRTYMPADGVYVVDVEIQRQKYRAMASVGKNVTFDGEEARFEVNIFDFNQDIYGETVMVYWLDRIRDMTKFDSVDQLVDQLKADEEVTRNWS
The following text describes a protein:
Function:
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
Subcellular Localization:
Nucleus.
Sequence:
MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIAMKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPVDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPITDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMPVPPGHLNSTGVLLEVGGVLPMIHGGEIQPTTSAVAASPAASGAPTLSRLLEAGPTQFTTPLPSFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAAAVSTSESGAPVSQPEPCVPLEAVGDPHTVTVSMDSNEISMIINSIKEECFRSGVAEAPGGSKAPSIDGKEDLDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEESENKGLHDLVDIRDSGVEIKVEPTEPEPGMSGAEIVAGVGPVPSMEPPELRSQDSDEEPRSSAAGDIGEADGSSGKGDERPLSAVKTEASPESMLSPSHGSNLIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGDDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of positively charged L-amino acids L-Lys and L-Arg and, much less efficiently, of amino acids L-His and L-Tyr. Has antimicrobial activity. Inhibits growth of Gram-negative bacteria E.coli strain MC4100 (MIC=0.62 ug/ml), E.coli strain C921-b2, S.typhimurium strain AA 140 (MIC=0.62 ug/ml), P.aeruginosa strain PAO1 (MIC=0.31 ug/ml) and V.harveyi strain BB170 (MIC=0.25 ug/ml). Inhibits growth of Gram-positive bacteria S.aureus strain 6835 (MIC=0.31 ug/ml), S.pyogenes strain NZ131 (MIC=0.62 ug/ml), B.subtilis strain 168 (MIC=2.50 ug/ml) and B.subtilis strain WB600 (MIC=2.50 ug/ml). The antibacterial effect can be bacteriostatic, mediated mostly by H(2)O(2), as well as bactericidal. The latter appears to be due to unstable intermediates generated from alpha-keto-epsilon-aminocaproic acid, an intermediate of escapin-deaminated L-Lys, and H(2)O(2). The bactericidal effect is stronger at lower pH levels. Intermediates generated from L-Arg have no bactericidal effect. Inhibits growth of yeast species S.cerevisiae strain BY4761 (MIC=5.0 ug/ml) and C.krusei (MIC=5.0 ug/ml). Inhibits growth of C.sphaerospermum in a lysine-dependent manner. As components of ink, products from escapin's enzymatic activity may play a role in deterring eukaryotic predators.
Subcellular Localization:
Secreted.
Sequence:
MSSAFLLLACALVISVHADGVCRNRRQCNKEVCGSSYDVAIVGAGPGGANSAYMLRESGLDIAVFEYSDRVGGRLFTYQLPNTPDVNLEIGGMRFIEGAMHRLWKVISELGLTPKVFKEGFGKEGRQRFYLRGQSLTKKQVKSGDVPYDLSPEEKANQGRLVEYYLEKLTGLQLNGGPLKREVALKLTVPDGRFLYDLTFDEALDLVASPEGKEFARDTHVFTSEVTLDASAISIFDDHLGEDYYGSEIYTLEEGMSSVPQGLLQTFLDAAKSNEFFPNNHLKALRRRTNGQYVLYFEPTTSKDGQTTINYLEPLKVVCAQRVILAMPVYALRQLDWSQLRNDRATQAYRAVRPMPASKVFMTFDQPWWLQNERKSWVTKSDALFSQMYDWQKSEASGDYILIASYADGLKAQYLRELKNQGEDIPGSDPGYNQVTVPLKDAILEHLTEAYGVERDSIPEPVTAASQFWTDYPFGCGWITWRAGYHFDDVISTMRRPSLKDEVYVVGSDYSWGLISSWIEGALETSENVINDYFL
The following text describes a protein:
Function:
Probably a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB/C two-component system. May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition. Also confers resistance to H(2)O(2). Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB; AriR probably acts upstream of the RcsB/C system to stimulate the activity and not transcription of RcsB/C. 5-fluorouracil reduction in biofilm formation requires this protein.
Sequence:
MLEDTTIHNAITDKALASYFRSSGNLLEEESAVLGQAVTNLMLSGDNVNNKNIILSLIHSLETTSDILKADVIRKTLEIVLRYTADDM
The following text describes a protein:
Function:
Zinc metalloprotease. Provoques deadhesion of endothelial cells from cell cultures, and also degradation of fibronectin, fibrinogen and gelatin in vitro. Its role in the venom is not fully understood but it might act as a spreading factor that facilitates diffusion of other venom toxins. Alternatively, it might be involved in the proteolytic processing of other venom toxins or it might play a role in extra-oral digestion of prey.
Sequence:
MKGIESQTCLRFVPRTTERDYITLFKGPGCYSAVGRMGNAQPLSLGDGCVFRGTIIHELLHAVGFYHEHSRSDRDQYINVFLQNVDPRSVSQFQRLEPWQNRLISPFDYDSVMLYGSSAFARGPGLSTMLAKDGARLAEVFDKKDMDASDARRVNVLYHCSLNGQSNTKNKKTRPSVP
The following text describes a protein:
Function:
Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand. In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MLARTWSLVSKAVRTTTLQGGSTSRSISRSALHRLAKTPQSYKTHIYCKNTNIMPPLRCAHYATKPDAPNADIKKTFVSSHFKIDPNVIYSFLKRKNVIFKEVPSDDKKLRLRDCQWCHDTKSKYSNQYKLYINKDNGSYLCFRCGSRGSWFDFQQKYGDLTQVTDWKGEAAVPKEQATEEWVRQPDPLPTDFVDADGTLRAEPVQIPPEEVSNSSPSKRSSLTKTRREVKQIKTNGLKAEVVQKYLVGGTVARFFDDNDKQWKDFLCITFPWFGPLSLATAGTETLVRYKYRALGGKWLQRLEPIGGGWCVFGWNLIAPETSVIITEGEFDAMAVYQATGLPAISLPCGANCLPVEVITMLERFDKIYLWLDDDVVGQQAAQKYALKLGRERCYLVSTKLGATTGPKDANDALRQGHDLGTILKAARRLPHKQILNFNEIRSEVFRELANPDQVAGRQMRSFPTLNKLLKGHRKGELSILTGPTGIGKTTIISQISMDLCSQGVNTLWGSFELNNVRLAKKMLNQFAQKNLEKHLAEFDLWADKFSQVPLYFMRFHGGTEVEAVLDAMDYAVYVYDVEHIVLDNLQFMMQVGHFKGYERFDQLDSAISLFRKFATEKNVHITLIIHPRKEDDGQALSINSVFGTAKATQEADNVIIVQKGKYYRYLEVTKNRFSGDLGIVPYKYDKESHKYFELHGKDLQKVTANSTQNGPAAAARPPSAPPS
The following text describes a protein:
Function:
Part of a type III secretion system.
Sequence:
MLRIANEERPWVEILPTQGATIGELTLSMQQYPVQQGTLFTINYHNELGRVWIAEQCWQRWCEGLIGTANRSAIDPELLYGIAEWGLAPLLQASDATLCQNEPPTSCSNLPHQLALHIKWTVEEHEFHSIIFTWPTGFLRNIVGELSAERQQIYPAPPVVVPVYSGWCQLTLIELESIEIGMGVRIHCFGDIRLGFFAIQLPGGIYARVLLTEDNTMKFDELVQDIETLLASGSPMSKSDGTSSVELEQIPQQVLFEVGRASLEIGQLRQLKTGDVLPVGGCFAPEVTIRVNDRIIGQGELIACGNEFMVRITRWYLCKNTA
The following text describes a protein:
Function:
Regulates arginine biosynthesis genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCETWIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEILGTVSGNDTTLILTASNDMAEYVYAKLFK
The following text describes a protein:
Function:
Protease responsible for KMT2A/MLL1 processing and activation. It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity).
Sequence:
MTMEKGMSSGEGLPSRSSQVSAGKITAKELETKQSYKEKRGGFVLVHAGAGYHSESKAKEYKHVCKRACQKAIEKLQAGALATDAVTAALVELEDSPFTNAGMGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVANRLLCEGQKGKLSAGRIPPCFLVGEGAYRWAVDHGIPSCPPNIMTTRFSLAAFKRNKRKLELAERVDTDFMQLKKRRQSSEKENDSGTLDTVGAVVVDHEGNVAAAVSSGGLALKHPGRVGQAALYGCGCWAENTGAHNPYSTAVSTSGCGEHLVRTILARECSHALQAEDAHQALLETMQNKFISSPFLASEDGVLGGVIVLRSCRCSAEPDSSQNKQTLLVEFLWSHTTESMCVGYMSAQDGKAKTHISRLPPGAVAGQSVAIEGGVCRLESPVN
The following text describes a protein:
Function:
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MKITIRGKNIDVTEALKQYIEKRVTKFERFLTDTSEAIVTISTEKFTHKIDVLLKVDGHLIQAEGKTEDLYSAVDQVVEKLEKQVLKYKEKVQNKNKKETIKYPSALSEEVETAKRIVKYKKFDLRPMSPEEAVDQLELLDKDFFIFINSFSGDVNVIYKRKDGNFGLIEPAR
The following text describes a protein:
Function:
Essential protein involved in ribosomal RNA processing.
Miscellaneous:
MISCELLANEOUS: Present with 2950 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAVHTNRQILTRGKNYATKQSKKFGTDEVTFDKDSRLDYLTGFHKRKLQRQKKAQEFIKEQERLRKIEERQKIRQERKEVMEEQLKTFKESLNLEAEIEDAKNDKTEDLQVESDESWHGFDSDKDDGDNDNNESSVKPILKKGAITEIYDDSTTVELETLEPNDNFEYLAQLNNVKLEKAEKVLKQSINRATKYAKFLGVDEKQKKKPRVKKFRYLTKNERRINQRKANDNKRRR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.
Sequence:
MTVRPTVALSLLVVVLGAFASAQSDTDDGNYRFQTRPPLPDASVMPTLANGNIGFVAYGEYVHLNGVYNGLRGKSHRARIPNYGNIQLTACSPSSPGGVASTCTYQLNMRTGKFVTVEETGDYRLVHEMYPHRYYDTVLVNRIRIQRLGSTNTITARLSQIPGLQAADFTWQPSTEFVMWGQLYKSQCGVTVQVEEPTVQAFGHNVCVTYPAIPETVQIEPDTMAREFLFFTAFTMTEEDGRRQLEVVTGLTGAQEETLHMREMDRLWERYGISVERNDELDRVIKASAFYLFSSLPAHQVAASSGRYPFYGLAPAGLGRGGIEEQEYQGHSFWDTEIWMYPAILLMDPINAAKVLSYRTTVIGGARMNAMKHGFEGIQFPWESAFTGTEVTPDCCPEVADFQHHITADIVFAARQYFYATGNTDWLKSHGCRLAADSSLFWLSRASYNNATDLYDIHNAMGPDEDHPNVSNNAFTNVMAAHNLFFGEFASCYCRDQTVNETVRRELLQVARGLTLLYDAAGDFHPQFEGYQPGTPIKQADTVLLIYPLQHPMNVSTKANNLRQYSQVTRENGPAMTWAIHTIGHLELGEVQQAATMFDKSYRQYLRAPFNVWSENGNNEPGAGNFITGAGGFLQSLINGYAGVRLHQDRLEIKNARLPPDTRSLHLPTVEYRGVLFALTVNETGIKVAIRVEGQPDLKLTVDGTERRICKDCEYEGTTAIIQQTKDQIFEGCRLRPTTLGVKVADQTDAAPALRTTALAFLSLIVCSLLSKML
The following text describes a protein:
Function:
FAD-dependent monooxygenase; part of the benzoic acid degradation pathway also known as the protocatechuic acid pathway. Benzoic acid debradation begins with the conversion of benzoic acid into 4-hydroxybenzoic acid through hydroxylation by the benzoate-4-monooxygenase bphA, and its partner NADPH-cytochrome P450 reductase cprA which act as a mediator in electron donation from NADPH (By similarity). 4-Hydroxybenzoic acid is then converted into 3,4-dihydroxybenzoic acid (also called protocatechuic acid) by the p-hydroxybenzoate-m-hydroxylase phhA (Probable). Protocatechuic acid is converted into 3-carboxy-cis,cis-muconic acid by the intradiol ring-cleavage dioxygenase prcA, which is further metabolized through the 3-oxoadipate pathway to finally enter the tricarboxylic acid cycle (TCA) (Probable).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MTTDSYPKKYDIVIVGAGPVGILLSLCMSRWGYKVKHIDNRPVPTATGRADGIQPRSTEILRNLGLKRKIMAYDPAKVYDVSFWDPRPDGSGIMRTGNWPSCPRFIDTRYPFTTLVHQGKIETVFLDEIKKAGTTVERPWTIIGFKNDGLDATYPVQVQLKCLDTNVVETVRAKYLFSGEGARSFVREQLGIQIRHKDPISYVWGVMDGVVRTDFPDIQTKCTIHSDAGSIMVIPREDDMVRLYVQIASSSDPDFNPRKTATAEEVQNVAKKILKPYYIEWDRVEWYSVYPIGQGISEKYTLDERVFMGGDACHTHSPKAGQGMNTAFHDALNMAWKLHAVESGLAQRSILSTYETERKNIAETLLDFDNKYAALFSKRRPNAGEVGEAATAETGRSAEEDPFVKTFKDSCEFTSGYGVAYLPNIFNWDPSHPAKSPLFDVPGINLVTGKAFTPSTVTRLADSNFVHLEQEIPANGAFRIFIFAGRQSRSKKAIADFAANLEKERSFLSAYRRSDIGEISFFERHNPHSKLFTLCLIYAEKKNDIDMDSIPQILRDYRYHIYSDDIPDVRVPNATYAAHEKLGFDPEKGGVVVTRPDSHIACTVQLAEGSGTVDALNAYFGSFSTKPLGQEQASRL
The following text describes a protein:
Function:
May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.
Subcellular Localization:
Nucleus.
Sequence:
MNLFFFPFLLMSLMFQRMSNFMSCKLRTFLGEPMGEKCVAFVDGVGRDLARSLITCGYDKAYVLLGQFLLMHKKEEEFQMWLRMSFGATRQEAHMIANCLREWCNSFI
The following text describes a protein:
Function:
An aminoacyl-tRNA editing enzyme that deacylates Ser-tRNA and/or Thr-tRNA mischarged by lysyl-tRNA synthetase (LysRS), threonyl-tRNA synthetase (ThrRS), seryl-tRNA synthetase (SerRS), alanyl-tRNA synthetase (AlaRS), valyl-tRNA synthetase (ValRS) and isoleucyl-tRNA synthetase (IleRS) in vitro. Also deacylates mischarged Hse-tRNA(Lys) and Hse-tRNA(Ser), and cognate Ser-tRNA(Ser) and Thr-tRNA(Thr) in vitro. The presence of cognate ThrRS abolishes the Thr-tRNA(Thr) deacylase activity, hence this activity is not applicable physiologically. Not able to remove the amino acid moiety from cognate Val-tRNA(Val), Ile-tRNA(Ile), Lys-tRNA(Lys), Ala-tRNA(Ala) or Pro-tRNA(Pro), or from incorrectly charged Ala-tRNA(Pro), Cys-tRNA(Pro) or Leu-tRNA(Pro) in vitro. May be required in vivo to prevent mistranslation and to maintain growth when the error prone stress-inducible lysyl-tRNA synthetase (LysU) is expressed under environmental pressure.
Subcellular Localization:
Cytoplasm.
Sequence:
MTEMAKGSVTHQRLIALLSQEGADFRVVTHEAVGKCEAVSEIRGTALGQGAKALVCKVKGNGVNQHVLAILAADQQADLSQLASHIGGLRASLASPAEVDELTGCVFGAIPPFSFHPKLKLVADPLLFERFDEIAFNAGMLDKSVILKTADYLRIAQPELVNFRRTA
The following text describes a protein:
Function:
RNA-binding protein that promotes oogenesis by repressing fem-3 expression during germline development. Binds poly-U and poly-G stretches of RNA in vitro. Regulates target RNAs expression either by regulating their stability or translation.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MAEKQPMLSFAKVVSGQAEDASSPSQQVQHTQDSSHSSTQNENSQPEKQAHPPHNRREKENVGGRSERPRGEGKGKRRNNRKGDRKPRGETKTEKPAEKVATEEVKPVEIPVVLEPAPLPAINAWFKNKEEAEAAAAAAQKEQKSETAADQFIITATPVVQKSSAPIPEKKRAVEPTPKQAAPIKEKSKSRESKKEPWKTSTAPAATAPVTETVTVAATQDWPTLAKAELNGHVSPSNSDDNNESSSNSQHKTGGKMTKNSWKKVDISVDYGSKGKGAPRGNGGEKGTRRSANDEAVRRRSGEEDSASGDEQQYWSRSKDNKSPINEMSSDRVVDSGSNGIYYQQGGTHGWKKKVNNKAGSDMPTPPNSTSPHQSESNSPEHLPKDKAPIMNGNAKNAPAANRNGNNTSTAKTGDYWHKNGGERKEDKSQPKAYYQRNDRFQARANPHAPPKLTAAQRKERGPLPRWEDIEAGDDNFDYMTLMEAQYSQYYGAPQQFEHQLDPHQASILIQQAQQHMASFAPFRPPMPMLSPHLMSPPLDRDGGVTSPVSNGEPINTAIPFAPIYNPPTAPRPVTDDTLKEYVRKQIEYYFSEENLQKDFFLRRKMGPEGYLPVALIASFPRVRSLTEDYSLILEALKDSTKVDMSPDGLQIRAPVNPTIWPLMPTVSGADSLPGPSSQAPQQFRQNGPAATAAPVESQPQASSSKPQQPEEWEEVKTRKGKGKGRLTSGSQSTNDNKRQPQQQQKSLQQSGSDQPDLDFQFDNEISGGGGSAQTPKRPEKSKKAFLSAIDSEEIGDDVISKLIIMTPSRRTLDRTGDFSTRSQNQGEFNEEVEIGLRRYEEELWTVPQEKDIPTSKVSTISAEQFNEMRGNEDAKKTSDEPPEIPLPSGTQPTPDSVWTKKAKERAAASVTVPKSPMQRRESEEQKMNRFYPISKPTAPLDAKSPRKKKTRHSEKPPVEMPVAWVLGREDALPAAPIGIAASSSQVPANHPSISLLQEDRFVQNVYSTWRQACLKQRKSLGYDCAEMNTLYRFWSFFLRDNFNRNMYEEFRKLALEDAEIGSRYGIEALFRFYSYGLEKKFRPEIYKNFMKDVTTDVQKGELYGLEKLFAFLQRSKIAKQLVVDDYLTKELNKYKSTDDFRNLPQSTKK
The following text describes a protein:
Function:
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Sequence:
MSAANADFELFRVFLEKTCGIVLGSNKQYLVSSRLNKLMEQQGIKSLGELVQRIQTQRGGLREMVVDAMTTNETLWFRDTYPFEVLKQRVLPELIKANGGQRLRIWSAACSSGQEPYSLSMAIDEFEKTNLGQLKAGVQIVATDLSGSMLTAAKAGEYDTLAMGRGLSPERLQRYFDAKGPGRWAVKPAIRSRVEFRALNLLDSYASLGKFDMVFCRNVLIYFSAEVKRDILLRIHGTLKPGGYLFLGASEALNNLPDHYQMVQCSPGIIYRAK
The following text describes a protein:
Function:
G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MARVLQLSLTALLLPVAIAMHSDCIFKKEQAMCLERIQRANDLMGLNESSPGCPGMWDNITCWKPAQVGEMVLVSCPEVFRIFNPDQVWMTETIGDSGFADSNSLEITDMGVVGRNCTEDGWSEPFPHYFDACGFDDYEPESGDQDYYYLSVKALYTVGYSTSLATLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSSHCFVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWAVLRLYFDDAGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIIILVQKLQSPDMGGNESSIYLTNLRLRVPKKTREDPLPVPSDQHSPPFLSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFTMDFKHRHPSLASSGVNGGTQLSILSKSSSQLRMSSLPADNLAT
The following text describes a protein:
Function:
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Early endosome. Note=Clustered upon activation and targeted to early endosome.
Sequence:
IGIGEFGEVCSGRLKMPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGILRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPVSLHQLMLDCWQKERAERPKFSQIVNMLDKLIRNPNSLKRTGGEIARPNTTLLEPSSPE
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor (Probable).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with rpn2 and ubiquitin.
Sequence:
MESVFGRVRNETSERGKYGLVSVKAGKLQRKPGTNILQADHRKGVIYMQMASDELLHFYWKERARVSREVEDDYIIFPEEAEFIKIDECTTGRVYALKFKSSSQIHFYWMQEYSDEKDKETASLINQLIADPVNTTRTINSHNNSSSRGTDDSSTSQLLQLFGAASQDALQDFNWEVLSPTAEAPAILPRFPNVNESANMYRASSESNLNGPHATAGENGEDHEEATASPLDENIDYTHSRTLELLEQLQPLILNETTFVEPFSIDRESHRVITHPRVYPKIFPHSPSDLLRISGRAELSENRDFFKHLSSLMEAVAKPESESLREICNLSLEQVQSASGAELFLHALYDRLVNEGVIVISHITQEGSDGEVEEEGDVEMRESNEKDE
The following text describes a protein:
Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFISAIEAVNSDSSTDSNSDKAMPAILSSNSSMLSSKRTACSASEADCYNMGPSPLRLTFRTARQPWDAVLRGQTLYIALPPHVLPEGSREAFVALLEAAEEQLKCQHVVVVFESERPDRAMLVRTFMFLGFAVLSPTSPLVPPSLSSGHVCMLYNIE
The following text describes a protein:
Function:
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPFHQITTSVNFLSSLNKQKQAAVFQTHSFESTQGQHLQETHTQTNYNPGKLGSVMPVDLGKWSGPLSLQEVEERPQHALHVKYTGTEVDELGKVLTPTQVKNRPTSIAWDGLDPGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQSGPLKCDEPILSNRSGDHRGKFKVASFRKKYELGPPVAGTCYQAEWDDYVPKLCEQLSGK
The following text describes a protein:
Function:
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Sequence:
MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFTQFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLIDAMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHENRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELDKDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID