lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa. May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece; Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
Subcellular Localization:
Cytoplasm, cytoskeleton. Mitochondrion.
Sequence:
MSVQVVAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHRGLAGHLAEALAGQGPVTGLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEEAVAQLEEEKRHLEFLGQLRQYDPPTETQQSESPPRRDSLASLFPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATELLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDTEQALRRSSSLSKIRESIRRGSEKLVSRLRGEGAAGAAGMKRAMSLNTLNVDGPRAPGTQFPSWHLDKAPRTLSTSTQDLSPR
The following text describes a protein:
Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (Probable). Involved in regulation of antisense ribosomal siRNA production. Involved in response to cold-warm shock.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=As a part of exosome complex, translocates from the nucleolus to nucleoplasm in response to cold-warm shock.
Sequence:
MLAETLVAPGDKVLDAIGEYRMGKGLYEANRRIFASVAGFVNVYGFRDKSDNLVQVIEVRRSEDQLDNELLPFHGAIVTAKVMAVGLRFAKCDIISIGDKVYKKRFSALLPKKKLRPLEPELSEPFKNFVRPNDYILAKVCEDAEIKDKFVLSIAEDELGVVLCRGRFGEPMQKVDWNTVVSTRTGKTEPRKMAKVPQKCTLPTQSVA
The following text describes a protein:
Function:
Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Involved in the trafficking of the plasma membrane ATPase. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes.
Miscellaneous:
MISCELLANEOUS: Present with 2470 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Domain:
The second RanBP2-type zinc-finger is functional and binds ubiquitin.
Sequence:
MEYWHYVETTSSGQPLLREGEKDIFIDQSVGLYHGKSKILQRQRGRIFLTSQRIIYIDDAKPTQNSLGLELDDLAYVNYSSGFLTRSPRLILFFKDPSSKDELGKSAETASADVVSTWVCPICMVSNETQGEFTKDTLPTPICINCGVPADYELTKSSINCSNAIDPNANPQNQFGVNSENICPACTFANHPQIGNCEICGHRLPNASKVRSKLNRLNFHDSRVHIELEKNSLARNKSSHSALSSSSSTGSSTEFVQLSFRKSDGVLFSQATERALENILTEKNKHIFNQNVVSVNGVDMRKGASSHEYNNEVPFIETKLSRIGISSLEKSRENQLLNNDILFNNALTDLNKLMSLATSIERLYKNSNITMKTKTLNLQDESTVNEPKTRRPLLILDREKFLNKELFLDEIAREIYEFTLSEFKDLNSDTNYMIITLVDLYAMYNKSMRIGTGLISPMEMREACERFEHLGLNELKLVKVNKRILCVTSEKFDVVKEKLVDLIGDNPGSDLLRLTQILSSNNSKSNWTLGILMEVLQNCVDEGDLLIDKQLSGIYYYKNSYWPSHI
The following text describes a protein:
Function:
Probable methyltransferase; Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEYICRVNWKEINTNKQLQEAILEWTDRGLDDVNSLTRVDILKLISIHGLENDSNIIYDPESGTTKIEIIIDAKIFYGISSKWNLTFNFPEFGDHCISMYVDRKYGEINKEEFYKYTHDIKHIQNENNAVNGSVNVKESIASISNTNYNANYTTNNTTNNTTINTTNNADLVNDFTKFSLKKKASNYSSHMSTTSSTPIPTLCPVKTKALEETSSSSSSSLSSSPESILSALLDIPDIPLPTITQSEQLKSLISKLQPADLTAELQAELSKLPPDYLQSLDIPPELGFVQQEKPSPQSQSSPIPSNNYNRSNNPLFQTKYITPLAEASSKDVPIPITTKDPSKIFRNKISHILSRNIPPLTLLKDHFKEAVSKSFKKSSVKTLDELNETVEMVQTLFQHSLTDFRVMSNIDSIIHSSTNDLLAQYMQITEKISWEQTSQAYKDKGNELFQKRFFSDAIILYNEALRLHSLENNQDTSILSSIHSNRCLCLVNLEHYEAGAAEATRGIEINSSARLLHKLHYRRGICYYHLKKHSKAKKDFLRAHKLIEKMDSTDISSIESYLYKIKKLNLPLHEEEKYEEQLAKEKNVSGAATVNKYQSIVDSRVDLKYESDKVGRITEANSPIPENSLLFQERPYVSCLDRNYHSLYCYNCFKELLVPVYCKGCNNAQYCGDSCLKEDYKNQHSVECDKGFLLTCSHESLLVIRILIKKAKEYRELYGEPNNNNSKNNNNNKFENGPSSYIPTPVLKNVNIKKSNNKFDSNNLVLFDESLSELQNLQISRDDKLYEIPKDKTSLEQANIYLPNYEMINSFDPHILEHSNENLLSLIFDSLIIERFIGYYQKELGILPEDINISTILRHLCQLTTYTFAIPGFIYRDQTRYVPEQESPSQNLYTKYKILKYIEDKIGYAIYPMSSLMNHSCVQNTHLQYKGNTIVIKSLCDIEKGEEILGCYGPSAFLHPLRDRIVSLYKEYFFICRCKACSEKAGPDQLKCPGSFENNSNTQCSGTLLEKVSFQQLINKAESESKNSLSSQTMSSLSSFSIKSKKPLPVNHQILSNYEQHEDYENRVFICNKCGIELYGIDAHSLTSQVIISDNLFNAGVKALNKNNYSKEIENLFLKSLEIRRSLFKVSSKKIGDVYDALVRYFLTNEAGYTAALYLEKFIENISIRLLHNNSSDLGREYAKLGEVYLCIGEFSKSEKAIKKAEEILLNWRVEPSDDEVLFLLVNHKKLFSYASQFSI
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLSYISHCYVIINLVIYVSSEGSFQLKLLDLVNRNGVTGAGVCCSNDLFPNCRQQCRSSIRVCLKHYQAIVEPEAPCTFGNYSTPAIGGNSFVPDNTSYVRRHPIRFDFNFRWPGSFSMIVDILHEDRRHTEPPRTITRMIVSNGNLLTQAHNDDTWHTPPPYISHGVELRYAYRVKCKVHLYGSDCATHCHPRNDVFGHFTCDMHGNKVCMPGWMDTGGTKYCTTPICLNGCNTQRGYCQAPNQCICKVGWRGKLCNECSTTPGCMHGTCERPFQCNCRRGWGGLYCNQDLNYCTNHHPCLNGGLCTNSGEGSYTCTCQVGYIGRMCQYRISMCSSNPCNNGGECVDTNEGYKCLCRNGFYGVHCDVTHVTCRNSPCHNGGLCIQQHDHYECQCTNQWSGFNCEISLNPCNSNPCLNGGTCMIHNTGFKCKCPIGYIGDDCGVDICSNNPCLHGGTCVALKYGTRCKCTSGYIGKICGDIRGCLPTLCQNGGGCPTTLTGPQHSCICGFAFTLNSCETVEKNCGINFCNKEDCRDSSGRCECLKNFNCSVYFHQPTPTMKPQPPSKLIILNQPNTSQFNTTHWIAISFCVGTIVLILILTWACILYNRTNRNRSTKPDTSTPTDTTPTTQEVDTPPTLATKVEVNFTDEVNHLLEPEARVELPCSNCSHHKNQTTSTTKMGDPPTHEGARCPTYEEACEDSPCLP
The following text describes a protein:
Function:
Positive regulator of multiple nitrogen catabolic genes.
Miscellaneous:
MISCELLANEOUS: Present with 1180 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MHVFFPLLFRPSPVLFIACAYIYIDIYIHCTRCTVVNITMSTNRVPNLDPDLNLNKEIWDLYSSAQKILPDSNRILNLSWRLHNRTSFHRINRIMQHSNSIMDFSASPFASGVNAAGPGNNDLDDTDTDNQQFFLSDMNLNGSSVFENVFDDDDDDDDVETHSIVHSDLLNDMDSASQRASHNASGFPNFLDTSCSSSFDDHFIFTNNLPFLNNNSINNNHSHNSSHNNNSPSIANNTNANTNTNTSASTNTNSPLLRRNPSPSIVKPGSRRNSSVRKKKPALKKIKSSTSVQSSATPPSNTSSNPDIKCSNCTTSTTPLWRKDPKGLPLCNACGLFLKLHGVTRPLSLKTDIIKKRQRSSTKINNNITPPPSSSLNPGAAGKKKNYTASVAASKRKNSLNIVAPLKSQDIPIPKIASPSIPQYLRSNTRHHLSSSVPIEAETFSSFRPDMNMTMNMNLHNASTSSFNNEAFWKPLDSAIDHHSGDTNPNSNMNTTPNGNLSLDWLNLNL
The following text describes a protein:
Function:
Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Required for the elongation of fatty acids precursors of sphingolipids, storage lipids and cuticular waxes. Plays a role in osmotolerance through VLCFA metabolism involved in cuticular wax formation and endocytic membrane trafficking.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKVTVVSRSGREVLKAPLDLPDSATVADLQEAFHKRAKKFYPSRQRLTLPVTPGSKDKPVVLNSKKSLKEYCDGNNNSLTVVFKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKFLGYGEDCVIHPVQTYAMYYWCFHYFKRILETFFVHRFSHATSPIGNVFRNCAYYWSFGAYIAYYVNHPLYTPVSDLQMKIGFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPRGFLFNIVTCANYTTEIYQWLGFNIATQTIAGYVFLAVAALIMTNWALGKHSRLRKIFDGKDGKPKYPRRWVILPPFL
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MPPIYVKPENALKRSEELLALGTPQSQQQAFDNLVEVFQSKRFKQTPINVLEPIVTKFIDLCVVLSRKAHAKSGLLVFKSAAQTTNVGAIERVLNHFIAKAEARLAAAVEQAKKEVAALPDVPVVDDDLPLQPASLMLDCFVDSAGDRERIERRLIAPAQKFCWDSYDICLDIAKSNDRLEVIYQSIAHRAFHFCKIHQRKADFRRLCEQRLRKDLANAAKYSHQQHAINLSDPETLGRFLDTRFLQLETAVELELWQEAFRSIEDVHGLIAGRKGTKPSMMANYYEKLTQIFKAEGGKQTAVFHAAAWARYFQHAERAGIVNDKASGCVLLSALAVPLGEVEVKQRLVALLNLPKTPTREALVQDAAAKHLKRVPADIRQIYKILEVDFEPTTASKVLAPLITSLSPEYQPYLPALRDVVLSRLLQALAQVYDSVTLSHILDLVKPLDNTPWATDMSSLEKFLVTACRRGDIRASVDHVAQTITFVSTPPDANGLQTLAVCLYNTIQYLNPSRLAPVSRSDAFAAAIAQAEEERKAASHKRQIVIRRRELLEEAKLRREKEASTALAERLKIKAEEDARRAKEEAKQAEIDRVRKQIHETKQAEAKQLAASLAAQGALKVDISSIEDLDSSKLVAMQVEQLAKEKKELSERLRIVGKRVDHLERAMRKEERPLLAQDYERQKAEDRAAHDRANQIAREQAIEQQRAARELKQRLGRMLEDYEAVKERIESQMQEELKAAKEEARRKIEEEKAQLREKVIKRKREEKERKLKEAREAEERKRKEEEEAAQKAEEEARAAAALEAEAAAAEQRRAEREAQRQSDLERIRAQQEREEEALRRRQAEKAAATSGGSAYRPPARAGTTPPTASPAPSSGGPSWLARRKAMEAQSAGGAPVASSPKPVPSNSAAASAPASNGPESIAGEAEKPALTGSVWRRGMGARRGMPSTRGGA
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAMKTTQDINKDDEELCKEAEKFMQVYYDVMDRKREKIGFMYATISQSNAVWNGNPINGFDDICRFMAALPSTQHNIQSLDAQRLPEGVSGDMSGGMILHVAGSVTVDSDAQRAFTQTLVLGVEDGKYKVKSDRFRYVD
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Subcellular Localization:
Mitochondrion.
Sequence:
MRKISYGFTQLMKLHLHDYHVNLKAKMVPFAGYEMPVQYPQGVLKEHLYCRESCGLFDVSHMGQVKVFGEDRVKFVETLTTGEFQTKKSGQSVLCLILNEKAGIIDDTIVAKRDDHIHIVVNAGNKFIDMKQMDKIIKDYNYKVQYEYLKDKPLIAVQGPNAHKALNEIPFMFMVNIKKNGIDYQINRCGYTGEDGYEISVESSKAQELCDKLLATKMAQFCGLGARDSLRLEAGLCLHGHEMDDTISPYEAKLMWTVRKPNKETGKYNESAAFIGRDALPQRQKDAKFKRMGFITQSGIARPPCDIEFQGQKIGSVTSGTYSPNLKKGLGFAFINNEYAKDGTQLQADIRGSKVNITLSPTPFVPQRYYKPEKK
The following text describes a protein:
Function:
Component of the Set1C/COMPASS complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MKLGIIPYQEGTDIVYKNALQGQQEGKRPNLPQMEATHQIKSSVQGTSYEFVRTEDIPLNRRHFVYRPCSANPFFTILGYGCTEYPFDHSGMSVMDRSEGLSISRDGNDLVSVPDQYGWRTARSDVCIKEGMTYWEVEVIRGGNKKFADGVNNKENADDSVDEVQSGIYEKMHKQVNDTPHLRFGVCRREASLEAPVGFDVYGYGIRDISLESIHEGKLNCVLENGSPLKEGDKIGFLLSLPSIHTQIKQAKEFTKRRIFALNSHMDTMNEPWREDAENGPSRKKLKQETTNKEFQRALLEDIEYNDVVRDQIAIRYKNQLFFEATDYVKTTKPEYYSSDKRERQDYYQLEDSYLAIFQNGKYLGKAFENLKPLLPPFSELQYNEKFYLGYWQHGEARDESNDKNTTSAKKKKQQQKKKKGLILRNKYVNNNKLGYYPTISCFNGGTARIISEEDKLEYLDQIRSAYCVDGNSKVNTLDTLYKEQIAEDIVWDIIDELEQIALQQ
The following text describes a protein:
Function:
Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'.
Subcellular Localization:
Nucleus.
Sequence:
MFSPDGGLPAAPFGLLPDGGPPFPRGGYDGAAAQQLFFPFASEPDGARDAATARAWLPPPAGPPAKAEARPARPCRQGSPEPRAAPPATPCCGPAWAAPPWPGPAPPAATAVPGPPFPGPAAAAFPAAPGHALCPAALQPSSGGLANLGSSGSSSGAASEGGHSSDSGDEDAPTSEELEQFAKDLKHKRIMLGFTQADVGLALGTLYGKMFSQTTICRFEALQLSFKNMCKLKPLLQRWLNEAENTDNMQEMCNAEQVLAQARKRKRRTSIETNVKGTLESFFRKCVKPSPQEISQIAEDLNLDKDVVRVWFCNRRQKGKRLLLPFGNESEGVMYDMNQSLVPPGLPIPVTSQGYSLAPSPPVYMPPFHKAEMFPPPLQPGISMNNSSH
The following text describes a protein:
Function:
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival. Plays a role in the induction of apoptosis via p53/TP53, SRC and AKT1 signaling pathways. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTTTYFGPWLIRQSEIFFTTELSFALVNLKPVLPGHVLVCPKRIVPRVKDLTKEEFTDLWLSAQRISSVVEEHFNGDGITFAIQDGKNAGQTVEHVHIHIIPRKKFDFENNDQIYNEIEKEREPRSYEEMEKESSELRPLFEENKNKTF
The following text describes a protein:
Function:
Required for the assembly of mature ribosomes and ribosome biogenesis. Triggers the GTP-dependent release of ribosome maturation factors from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (By similarity).
Sequence:
MSIFTPVNNKTLTNIVVVRYKKGAAKFEIACYPSKVQSYRSKIEKDLNEVIQIHRIFTNVSKGIIAKKDELIKAFGTDNEQEIILLILEKGELQVSSKERDNQSEQTFKDIATIVAEKCVNTETQRPIPVSIIEKAMKDVHYSIHPTKSSKQQSLEVIKQISSVIPIQRAQMRLNITIPTKESKTLNRDKLMVLVSKIEEEDRDGGGLSIVCLVDPGSYRKIDELIKQETKGKGFIDIINLAVAKEGETKINETGKSAPTSTTTTTTTTTSSSK
The following text describes a protein:
Function:
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Subcellular Localization:
Cytoplasm, cytosol. Early endosome membrane; Peripheral membrane protein.
Sequence:
MADEDGDGIHSGQRNGGGGFGSVGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGIRKGDRILEVNGVNVEGATHKQVVDLIRAGEKELVLTVLSVPPHEAENLDPSDDSSGQSFYDYTEKQAVPISIPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILNQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRIALPDKSTVTVRVKKNSTTDQVYQALTAKIGMDGITANYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTVRKWLFTTSEEALLKDNDLAVSFFFHQAVDDVKRGYIKAEDKSYQLQKLCEQRKMLMYLNMLRGCDGYNEIMFPHCACDSRRKGHVVTAISIKHFKLLACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKEVEEEATDKDNKNCSIDSTCRKNIFHVVRLQQKDTST
The following text describes a protein:
Function:
Orphan nuclear hormone receptor. Required for metabolic and physiologic responses associated with dietary-restriction-induced longevity. Modulates triglyceride and lipid metabolism and autophagy, associated with dietary-restriction, probably acting via regulation of transcription of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MFSTLSPSAIDDILRHAVHFGQGTTAIAPSPVTFISTTTQQSLGATYPGVFNPTTPTFNHYQHQALPVTMHTSTSSAHHTTTGHGRGRRKNSTINLVCVVCGDQAFGKHYGVNACNGCKGFFRRSVWHNRQYLCRFEGRCAIAKEHRNVCRACRLKQCFVAGMNPRAVQSERVEREQNGSPNQIEEDDYKDLSSPDTCSVEIQTDVDEQKPSSNNSAPLPSMELEMAKLSEQIVEMHRAVCSYVDPVTKRENFDMKMETETTKIAFMNAFYNPEMIGPRTPLDITGRRVATVKDVMDEWKRNFVLFSDWLRALPEYNQMSIEDQIVLAKNRYGTFHWWMCANWTVQAGCEGVCYSNGAYFPKQPEAQCIPDVKGSSGRMYDSLSIPIKELNLDETEIVLMLAVIIFSDEITELADLTPAGKEHVRMVGNRFVRMLHHHVNSKEYGEAMENGDDTQNSSESQAAVRIAKMMILLSATTNLVYLTSDNIQLMEVLHVVPSEYLCHEVQFIQNSYETP
The following text describes a protein:
Function:
Calcium-binding protein involved in larval development and metamorphosis. Likely to function as calcium buffers mediating the transport of calcium from the sea water to the blastocoel where calcium is required for skeleton formation.
Sequence:
MAAELLFSKEKIAVLKGKFSELENDDGSIGVGKLEELMTSLGKCFPQTELRKKINKVGDDGNGTITFSEFLTILAGETDWAYSQYRTAFNAMDKNKDGFLSADELREAMSTIAQPMTDEQIDAFIKRADYNEDGKFDRDEFTMMVLDEMVRF
The following text describes a protein:
Function:
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity).
Subcellular Localization:
Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.
Domain:
The fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability.
Sequence:
MWWPMLWAFPVLLCLCSSQALGQESGACPDVKIVGLGAQDKVAVIQSCPSFPGPPGPKGEPGSPAGRGERGLQGSPGKMGPPGSKGEPGTMGPPGVKGEKGERGTASPLGQKELGDALCRRGPRSCKDLLTRGIFLTGWYTIYLPDCRPLTVLCDMDVDGGGWTVFQRRVDGSINFYRDWDSYKRGFGNLGTEFWLGNDYLHLLTANGNQELRVDLREFQGQTSFAKYSSFQVSGEQEKYKLTLGQFLEGTAGDSLTKHNNMAFSTHDQDNDTNGGKNCAALFHGAWWYHDCHQSNLNGRYLPGSHESYADGINWLSGRGHRYSYKVAEMKIRAS
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MKNPKQLNPNWAQLRQKLGYSNKSATETQHTILGKRKERSDNDNEEASDAELNVLTPTSSDSSITTEIAMDCEMVGVSPLGNKSALGRVTLVNKFGNVIYDEHVRPVDRVVDFRTQISGIRPRDLKKAKDFRIVQKEVAELLKGKILVGHALRNDLKALLLSHPKKDIRDTAEYQPFLKEGRSKALRHLAVEVLGVKIQNGEHCPIEDARAAMMLYVKKRREWEKSVKDLVKMKLKQKKRKPKKQRKEGSTAA
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.
Sequence:
MSSAVLPSIWFLSAPGKPSKQEAVASLKDAIASKNADYAEVFPYTLPDFKVGTLDTLVVLSDDLAKTDQMLEASVVKIADGLKGLLNQDLVQWKSSLVIGDKKIETYLKSFQWNSMKYRSDKTLREIADTIIQEVSSIDTLMKTKSQVYSQVKGVLQGIQRKSSGNLAVRTLGDVVKKEMFVLDSEYMATLLVAVPKHSTKEWLSDYETLTQMVVPRSTVKIVEDDEYVLFSVTLFQRVIEEFSNKARERKYIVRDFKWDPERLSADKKQLADLTAAEREQWSTLLRLSKTNFGELYSCWIHIKALRLFVESILRYGLPPNFQPITVMAKPKHEKRVRDTFNKLYANADGSQKSGDAAAAAAAADAGMDENMQMLLGEKDYCPAVIFPINTIG
The following text describes a protein:
Function:
Required for the formation of cilia.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MQQDDEQEKSQQLQNFQSDDLLEKLKLLNYEKHLLKEFKLKPLSRFYFVKATNPGEQFYMFTLICWWLCKKLGKDMERPQEYDDPNTVAANIIKLLGEIDVPVDFQPNKLIRGAGPICLSVLEVLSTQACKVAQVGYQKLHIAQEEEFLGDYLEDNAEIILEKLEDEQNAAALSDDSDMELEAHNFRQLNWLNRPQKKSNGDVNLDERNPELDARMSDHQEWHLELERVLPQLKVFVKADARDWRTHISQMETLKTNILENSDTAEAQLKKLHSEFTFDLEKIESREKHLNNELKPLIQQFKELSIELSTIQYAQNQLQEDMEKQTAELNEVMMEQELKKEEMERRGQAMSDGSSVQQIRKAIAKLKDDTAQLNLEVALLVHAHDQDIVVRQLQQNQTTDLANNP
The following text describes a protein:
Function:
Cilium-specific protein required for cilia structures.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MSNSNRKEITGLNRMTPKGLKELCKKDKLYQTPRLNDVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSKLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTLILACKELTYLDSRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIRMRNSHRPPDQQDPLLRSSDSEDDTCAETARKKVALENGCVDDLWEEVSGEQPISEDGTNSSSSLEDNDGTSSQDDLIAEKLSNRRTLEGRPTVLYETEVSNVKSANNDINIFEEGVGKASQIIIEDKPVTKIKLINEPSCMNDKSAMNCTSMGPVVKENDFDEDAEIKNVDDMVPCQNLIKSNEDINSEFGFSSKLKQDFDQTCTALRNDAECKEFDEELTIKESESKPFNEMYDIFAAEDDKLNETLDLNLNETTCPHHVHDNFFSEQNKMPSFYEEDIMINLLPKTKEKTLLEKDSIIENEKCAHDLDEMGRQMEEDLAELRQSTQNLIGISIDETARTDSETDEEDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSDRNIALSNESDQDDKQDQLFAKILDDATENIPKRIFGTGCDALSSVWPQEECLLQLTLPENKESPAQEDTFKKSITNSTSFEKANEICVRMDQKMAEEEEALGKLLHDLEGEINNVYDINTKVKYEENTSTNESDAVSICTSLLDDIIVGLTFDEVLCHEKPKSFEFGLIESDEEFSYSFEPKLEKLVPPALEDPARGKSLRECLDTFSDFVSSMADPKLPVMLGRNPTSGVEKIRAAQELLKTKNLSDLYKDTAESLNSQVAKEIEKRKRRVAASATRCFNQRDKYDDTLELVENRLMIVKKDSGDLEELPPPPPLISDTESEDDNPTEDNYTPGNEVHRHGTKTQDSKEHLMSNLLNQNQDDIIEGKKNDSAEDEFYSLEAMTTFGNLDAEFFQKLDLQKVNASEDSEPAINCMRSYNELQAYMKSGSLNTQLNSEEAEMLQTMCSRVASDVDKPKSQNSKEEEEDDLLKKMVLRMKEYEEREHQLQLISHETSSELGPIKLSIGGSKLFEQNTKIPESVLVHSENEPTRNNKPINTKNTNDKESSDIMEKNGDPSVTTSFKTSHKSIDDDIQSDVSTDYESGEEVVVVEPPTLSEAVLKSFYSDEFEADSKMVHELEEATRRNLRRYNPNIMHISTSNHPFSTNNILPTKTSTSELSEGAKAKWAKIAERLHEFLDPETIANLNKEQFGESDECEDSQDDNITDITVEETNLKKDTKLVVLEEYNNTHTCDGNSCPSKLDDSDQFASLKGFEKIKETPTHNMGLSSVMSASQNKTSETLPNEIGNKITDFSSFKTSSTDLINSEGVKTEQIQCNLQILSDEGDVVVEELSVNAQVSSFK
The following text describes a protein:
Function:
Dehydrogenase that catalyzes the oxidation of several aminoaldehydes. Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 3-aminopropanal to beta-alanine. Catalyzes the oxidation of 4-aminobutanal to 4-aminobutanoate. Catalyzes the oxidation of 4-guanidinobutanal to 4-guanidinobutanoate.
Subcellular Localization:
Peroxisome.
Sequence:
MDIPIPTRQLFINGDWKAPVLNKRIPVINPATQNIIGDIPAATKEDVDVAVAAAKTALTRNKGADWATASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDEAAWDIDDVAGCFEYYADLAEKLDARQKAPVSLPMDTFKSHVLREPIGVVGLITPWNYPMLMATWKVAPALAAGCAAILKPSELASLTCLELGEICKEVGLPPGVLNILTGLGPEAGAPLATHPDVDKVAFTGSSATGSKIMTAAAQLVKPVSLELGGKSPLVVFEDVDLDKAAEWAIFGCFWTNGQICSATSRLILHESIATEFLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQYEKILKFVSNAKSEGATILTGGSRPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFSTEEEAIDLANDTVYGLGAAVISNDLERCERVTKAFKAGIVWVNCSQPCFTQAPWGGVKRSGFGRELGEWGLDNYLSVKQVTQYISEEPWGWYQPPAKL