lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Polymerase involved in the biosynthesis of the B-band lipopolysaccharide (LPS). Catalyzes the polymerization of the O-antigen repeat units on the periplasmic face of the inner membrane, leading to the formation of the lipid-linked O-antigen molecule.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYILARVDRSILLNTVLLFAFFSATVWVNNNYIYHLYDYMGSAKKTVDFGLYPYLMVLALICALLCGGAIRRPGDLLVTLLVVILVPHSLVLNGANQYSPDAQPWAGVPLAIAFGILIIGIVNKIRFHPLGALQRENQGRRMLVLLSVLNIVVLVFIFFKSAGYFSFDFAGQYARRALAREVFAAGSANGYLSSIGTQAFFPVLFAWGVYRRQWFYLVLGIVNALVLWGAFGQKYPFVVLFLIYGLMVYFRRFGQVRVSWVVCALLMLLLLGALEHEVFGYSFLNDYFLRRAFIVPSTLLGAVDQFVSQFGSNYYRDTLLGALLGQGRTEPLSFRLGTEIFNNPDMNANVNFFAIAYMQLGYVGVMAESMLVGGSVVLMNFLFSRYGAFMAIPVALLFTTKILEQSLLTVMLGSGVFLMLLFLALISFPLKMSLGKTL
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKPHFEIRTTPSLGENQHMRDRSSSFTVKTYLFVYDLMQFCGHSWIFTNMIIRYMSFGKDSLADTFYSIGLVMRLCQLLSVLEILHILIGIDKSRLLPRFLQITERIVVLFVVINSQEEVQGKYIVCVLFFLWNLLDVVRYTYNMLARMGIHYLPLTWLNFSLCILLYPLSVLAKAFAICVSLPYFETFGTYSVKLPFPFAFSVYFPYVLKMYLLVLFTGMCFIIRNLFSERKAHLETGNSKKKSS
The following text describes a protein:
Function:
Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.
Subcellular Localization:
Nucleus.
Sequence:
MGEPLCEEDWLALVDEASRNARDLEQRIEVVELYKRAISAEPWSNTLWLARCDWVLSLYTDCRDPDAGWPEEEQELGQELFSLQTVQDLWQEAAAATQFRLNDSHELWNRWITIELEELAKSPSREYVERIRKIFFDRLQTPHSKWDETSQMFSTFLTKYDEPSYESTMVQITQMGSGARHLYAQREEHELKLQQAIATGDKERVASVMKEYLEWETLQTLMKPKKGLPQSPPILAVALYERALASTILGRDSGTWEDYIAFVQQSYTVNPEAQLGNPLYIVQRATAHCPWSGSLWARYILLAETQNLDFSSIEDIKHAATRSGVLDREGKMDEVIEVYTAWCGYLRRRTLNRAAEDEAFDVADAGLPGSLEAVQDWGRRLHKREYTDPLFRIERIMIQYLTQKGSIDEAPIRTKDLDWPEAIMELYIAHCNNYEDAHALLAAKDLVRRQFQLVTKRREKLAVEQAELYAQQQPHVVTPDPTDEESPGNSKRKREPTSEDANGNTHKKIKNEQPVADPEALRQQHLTRDRENTTVIVTNLPPEVTQTKVRQYFKEYGHINSLALKTEPDKLSSTCLIEFRSNDDVQSAFLRDGKFFGENQIKVESGTGLTLYVTNYPPPADENYMHNLFKDCGEIFSIRWPSLKFNTHRRFCYITFRNAEAASAATQLDGKLLENKYKLVAKYSDPAGKKQREGATAEGRELHITNLDLSLNEDDLKEVFAKYGQVESVRILRTHKGESKGAGFVVFEKKDEANSALELDKTKLKSSILHVELTQSRNYKPIATSTEKGTSASPVPDADGDAAMSLTSTADHPNKNQHALHQPSEVSNRTITLLNVPDTINDARIRAIAEPFGTIIKVVLRPDHQGAIIEYEDVNSAGKASLGLENYEITPGRRLKTGGMKDLFAQSSEVKSDRIVIGRTAKKEKEKASSSTNTGMSTSNLMQPSAPIRRPGGRGGLGQKKGLGFSGAKKSAVDSDATSSKPKSNADFKKMFLSGGKE
The following text describes a protein:
Function:
In vitro phosphorylates phosphatidylglycerol but not diacylglycerol; the in vivo substrate is unknown.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKFGVATVIAGGGDGTINEVSTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGDAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGSVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHDITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.
Sequence:
MRRVTLFLNGSPSNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCEGEPFIDPQTDARPPGGLLGSHTDWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLEEARFFGIDSLIEHLEVAIKNSQPPEDHSPISRKEFVRFLLATPTKSELRCQCANLQGVKMLCSNAEGASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEEMLTPLHMSQSVR
The following text describes a protein:
Function:
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal.
Miscellaneous:
MISCELLANEOUS: AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene.
Subcellular Localization:
Cytoplasm.
Sequence:
MRCASRSDELVFFVNGRKVMERNVDPEGTLLTFLRKNLRLTGTKYACGRGGCGACTVMVSKHDPVSRKIQRHFSVTACLMPICSLYGAAVTTVEGVGSIKTRLHPVQERIAKSHGTQCGFCTPGMVMSMYTLLRNHPQPSEEQLTEALGGNLCRCTGYRPILESGRTFCMESNSCQQKGTGKCCLDWGENDSSRLGKKNEICTKLFAKEEFQSLDPTQELIFPPELLRMAENPEKRTLTFYGERVTWISPGTLKDLLELKVKHPEAPLVVGNTSLGPAMKSQRQFHPVLLSPARISELSMVTKTSDGLTIGAGCSLAQTQDILAERIAELPEEKTQTYRALLKHLRSLAGQQIRNMASLGGHVISRHCCSDLNPVLAVSNATLNLISAEGTRQIPLNEHFLAGLASADLKPEEILESVHIPHSQKWEFVSAFRQAQCQQNALPHVNAGMRVLLKEGTDSIEDLSIAYGGVGAATISAHRSCQQLLGRRWNELMLDEACRLLLDEVSLPGSAPGGRVEFKRTLVVSFLFKFYLEVLQELKKLVKLFSVAVGADSRHRSEVSDQFLSALEDFPVTIPQGVQTYQNVDPHQPLQDPVGRPIMHLSALKHATGEAMFCDDIPVVDKELFMALVTSSRAHAKIISIDVSKALELPEVVDVITAEDIPGTNGAEGDKLLAVEEVTCVGQIICAVVAETDVQAKRATEKIEITYEDLEPVIFTIKDAIKHNSFLCPEKKLEQGNVEEAFEKVDQTIEGEVHVGGQEHFYMETQRVLVIPKTEDKELDIYVSTQDPAHVQKTVSSTLNIPINRITCHVKRVGGGFGGKVGKPAVFGAIAAVGAIKTGHPIRLVLDREDDMLITGGRHPLFGKYKVGFTNNGRIKALDIECYINGGCTLDDSELVTEFLILKLENAYKIRNLRFRGRACMTNLPSNTAFRGFGFPQGALVTESCITAVAAKCGLPPEKIREKNMYKTVDKTIYKQAFNPETLIRCWNECLDKSSFHSRRMQVEEFNKKNYWKKKGIAIIPMKFSVGFAATSYHQAAALVHIYTDGSVLVTHGGNELGQGIHTKMLQVASRELKIPMSCIHISETSTATVPNTIATAASVGADVNGRAVQNACQILLKRLEPIIKKHPEGTWENWIEAAFEQRISLSATGYFRGYKAFMDWEKGVGDPFPYYVYGAACSEVEIDCLTGAHKKIRTDIIMDACCSLNPAIDIGQIEGSFIQGMGLYTTEELKYSPEGILYSRSPDEYKIPTITDVPEEFNVSLLPSSQTPLTIYSSKGLGESGMFLGSSVFFAIADAVATVRRERDIAEDFMVQSPATPERVRMACADRFTKMIPRDDPETFKPWSIPIA
The following text describes a protein:
Function:
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
Subcellular Localization:
Cell junction, tight junction.
Sequence:
MRRAKSRRGPCEPVLRAPPPICYSPSSPVQILEDPAYFYPDLQLYSGRHEASTLTVEASGGLRGKSVEDPLSSFHSPNFLRTPEVEMRGSEDVASGRVLQRLIQEQLRYGTPTENMNLLAIQHQATGSAGPAHATTNFSSTETLTQEDPQMVYQSARQEPQGQEHQGDNTVMEKQVRSTQPQQNNEELPTYEEAKAQSQFFRGQQQQQQQQQQQQQQQQQQGQGPLSHTYYMAGGTSQKSRTEGRPTVNRANSGQAHKDEALKELKQGHVRSLSERIMQLSLERNGAKQHLPSSGNGKSFKAGGEPSPAQPVCKALDPRGPPPEYPFKTKPMKSPVSKNQDHGLYYNDQHPGVLHEMVKPYPAPQPARTEVAVLRYQPPPEYGVTSRPCQLPFPSTVQQHSPMSSQTSSIGGTLHSVSLPLPLPISLAASQPLPASPNQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGCYDNADKLHKFEKELQSISEAYESLVKSTTKRESLDKAMRTKLEGEIRRLHDFNRDLRDRLETANRQLSSREYDGHEDKAAESHYVSQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELREKQAYVEKVEKLQQALTQLQSACEKRGQMERRLRTWLERELDALRTQQKHGTGPPVSLPECNAPALMELVREKEERILALEADMTKWEQKYLEESTIRHFAMSAAAAATAERDTTISNHSRNGSYGESSLEAHIWPEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAGKTDSASLRPARSVPSIAAATGTHSRQTSLTSSQLTEEKKEEKTTWKGSIGFLLGKEHQGQASAPLLPTTPASALSLPASTTSASSTHAKTGSKDSSTQTDKSTELFWPSMASLPSRGRLSTAPSNSPILKHPAAKGAVEKQENSPGHGKASEHRGRVSNLLHKPEFPDGEMMEVLI
The following text describes a protein:
Function:
Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPSPRPRGSPPPAPSGSRVRPPRSGRSPAPRSPTGPNTPRAPGRFESPFSVEAILARPDPCAPAASQPSGSACVHPAFWTAASLCATGGLPWACPTSWLPAYLSVGFYPVPGPRVAPVCGLLGFGVTGLELAHCSGLWAFPDWAPTEDLQDTERQQKRVRTMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVRVWFQNRRVKYQKQQKLRAAVTSAEAASLDEPSSSSIASIQSDDAESGVDG
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis. Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells.
Sequence:
MPPKKAQTRRIVSLDSLFGHTLLNITGEPVTPTKIAIFQLIRTLFHAHFGVGAVPSLKPFDKDEKTRVFTVLYGLIIMKSEISYDDFRCIVRILNDGLGRSIYYRFVTSMEKLAHGEDQIEMLFEDAFYTAKRPNHEKVLKREDSWLDELTFMNSNSFLYIWIKRVMMQYTRTSQNGTFEIAEKFQKWIISGTLEIISHPILSGINRALPTEIDCSIRARHWCAAQLRLVQLCPTKAMSYFQILDWCDTIHRRHHDVVDVHLLRAAIFVQLKNSSDAVKSLKQFFDMSMLEITENSKHALETLKLMSPSQVALRFGPILQGRVHRIFGERQIASALFAESIQQSQVNVDDMCNRIANMEVTINSIYMSGPLLQRLSGETFAAGKKEEESVENERRVQQNSVHAAVDLNVPTLRSLQKNFREDYELHAFLVSMCKFLLCIQDMMDGKFFKHNSTADYVSVGFHRLRLLLDMNNKGFVLQAFANAIMTSGLIQSGMYHQAKRVAETMIVSNCDAPNSPILETESHAVAGVNLVYSLAAVGDYEKAQKTIDILKNRFPENINWMAARHVDICSKIVNFERNFLLNKYSECSRHLAGLETSAPLEFVLRKSLLLAATGKLAEAVLLLGTYECGDVRGSMRIHMQMATIHTAYGQFETAEIQIQEAGKVAVNAHFLDANLLVVRRVGSLMLGRFMAREAYQVLHALSAKIEHFGSFIEKAIYHVSMARCLRLMHKDPRVHLKQCKAQIIGNKWPAMEKLLLTELTILHHSGGLYPDEQKEMKAKERFGKIEADFPGPCTWMFI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MPFLRPCVLLLQESKPLAWSGPLPPHWLQWVRPRLWLQLPLGFHSLSSPRPPHLPLSQASSFLQLPSTVPPFLSTMALSLCVMDMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRMHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPNGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCRCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPPGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSATATEAAGPRSHSADSSSPGA
The following text describes a protein:
Function:
Probably act as a zinc ion transporter moving zinc from the nucleus/endoplasmic reticulum to the cytoplasm. Involved in zinc ion homeostasis and cellular distribution.
Miscellaneous:
MISCELLANEOUS: Originally MSC2 was identified in a screen for mutants that show an increase in meiotic unequal sister-chromatid recombination (SCR). MSC2 may also be involved in chromosome instability, rather than SRC; MISCELLANEOUS: Present with 1070 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MNLQELLAKVPLLLSYPTIILSSNLIVPSHNDLISRAASTSAAEYADEKLIFFSTDHAIRLIFLPTFVASSFNLFAHYFNFINYSSRRKYYVLFTAIYFLSILTAIFHPIQSTCITLLIIKLLTTADESSPKIALNFKTILKTFVPFITLTLVILRWDPSFDASSGDVNKISTSLAAYALLILTLRYASPLILSTLSSSIGVVSKDTSVAQHSISRNKRFPLILVLPIFSFVLLYLMTIVNKTYNIQLLMVFVFFGCLSIFFLSLKDLFTEDGNQKKGGQEDEYCRMFDIKYMISYLWLTRFTILLTGIMAIVVHFLSFNEITSSIKTDLLSLLFVVVAEYVSSFSNKQPDSHSHNHAHHHSHLTDSLPLENESMFKQMALNKDTRSIFSFLLLNTAFMFVQLLYSFRSKSLGLLSDSLHMALDCTSLLLGLIAGVLTKKPASDKFPFGLNYLGTLAGFTNGVLLLGIVCGIFVEAIERIFNPIHLHATNELLVVATLGLLVNLVGLFAFDHGAHDHGGTDNENMKGIFLHILADTLGSVGVVISTLLIKLTHWPIFDPIASLLIGSLILLSALPLLKSTSANILLRLDDKKHNLVKSALNQISTTPGITGYTTPRFWPTESGSSGHSHAHTHSHAENHSHEHHHDQKNGSQEHPSLVGYIHVQYVDGENSTIIKKRVEKIFENVSIKAWVQVEPQNSTCWCRATSMNTISANPNSLPLQPIAN
The following text describes a protein:
Function:
Involved in resistance to ionizing radiation.
Miscellaneous:
MISCELLANEOUS: Present with 721 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MRAYGKRGPVLRTPFRSNKGLPSSSDVEFSDDDVNSVIPDVSSTISSSIADHPIEGLLDEPRKAQDSSSSFDGANEKPSSQLDSKRNDQNVKIITSSDTSMAFMKDEKLSAFNFLDGSKASKRKRRRTYQKHDANITSSIEPDVQDEDSITMHNEFESIRKIYNDINEFILKLPRADDDILNKMLENEMKMDDSIENNSIRTSKDKKYGKFRTILINKNKENEIMGEEVDQKANTLSLNNADNSNAEKEGLTSTNHYNELKNMGDTIKYQDDIEFLLSNSKSNDNTTVPINEYFKKLLNLSLMIINDEEFFQYAKRYFKKEIIKLSFAQFRSDFPELILLQGYLLHKVSESQSDFPPSFDNFSIELSKDDGKIRTKKNKHIKKLSHLNFEDFLRKTQFKTGLYYSLSLWEMHGNLSLDIIKRISILASNKDLFSRHVKTFIPLLEKLITASEFCHMYIEQPEMFDSLISNLNNQFKDMLDDDSLIKILILLTNMEVHNYTLWKEADMIFQSSMNTILESIHPLTDAKVDNILLHLGLCLNICSRENSRLKLDGKLWYDMKTIFVKMIRDGSDTENRLVQGLFYLNFSFLIKQRKENSNLDPGELNLLLVELEAFKSETSQFNEGISNKIEIALNYLKSIYTSERITI
The following text describes a protein:
Function:
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
Subcellular Localization:
Nucleus.
Sequence:
MSASPTDPSIPTDREDSQAGLSPGLLCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRKLIYRCQAGSGTCPVDKAHRNQCQACRLRKCLQSGMNKDAVQNERQPRSTAQVRLDSIELDSNLRSEHLPTTRAGPQPASPIVLGLRVPSSASTMAAPGARALTPPGNHRFMASLMTAETCAKLEPEDADENVDVTSNEPDRPLTDDQPGSYPSTSPENVYETSARLLFMAVKWAKNLPVFSNLPFRDQVILLEEAWSELFLLCAIQWSLPLESCPLLSVPDPTPGIQGKLMSASIETQILQETIARFKSLTVDPTEFACMKALVLFKPETRGLKDPEQVENLQDQSQVMLGQHNKMHYPSQPVRFGKLLLLLPALRFISSDRIELLFFRRTIGNTPMEKLLCDMFKN
The following text describes a protein:
Function:
Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. ERG12 converts mevalonate into 5-phosphomevalonate. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Miscellaneous:
MISCELLANEOUS: Present with 3300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MVVSHQGSTDCKMKDTAVDGSLLGSTIAPDGFVSGAFLQRRIEFHPARKAISTVGSSFGDVKIEKLNPNVSGSSQTMTGKDKLLVTNAGSLVNVIRSDVVEHREHLTDPEISFRITFRRIGAGLANLGNTCFLNSVLQCLTYTEPFAAYLQSGKHKSSCHTSGFCAMCALQNHVMSALQSSGKILSPSHLVKNLQCISRRFQRSRQEDAHEYMVNLLESMHKCCLPSGVPSESSSAYEKSLVHKIFGGSLRSQVNCTQCSYTSDKFDPFLDLSLEINKADTLQKALKHFTAFEELDGGDREYQCQRCRKKVRALKRLSVHKAPYVLSIHLKRFGSHVPGQKINKRVSYEPVLNLKPFVSDPTDGNLAYTLYGVLVHDGWSTHSGHYYCYVRTSSGIWHSLNDNKVSQVSEKVVFAQEAYILFYIRNKNSMPKRTFETIEKKSNIANTSVNSGLKISSSDSNKAAGKVPIDYTDLSVKATPTVSLLQSNERKELFHSQRLPSPEGSKSEYNNSKESGENHGVDLSTDSDSSSKENKCRMVVENLVISLSNSKKDMLPTNASAKLVFQNEGKDTAIGVSQQNPCTARSDYVSKNHLDQKNPCTARSDYVSKNHLDQKDDILLNKVTDDNSRAMETRNKVHVPTLSALKKPDKVKILKNDSKLINSFNKPHFTDPLKNKVLACMESSNSLSNETETKLKRKSKHSRKRNVFHGPKHQILASLCVRKKRRKNYMGEKNYSNIEEEAVSASVSPDQDISKTANVIKVEEKCHSNIKKEKSRGSKDGCIDNGQSVVRNTENDAVMVEMGSNQNSVQTDVRVVKKSGDVKMSNLTWGLGDSSVTKRNDRESLSSSCYQSAHEPTVSIGYVLDEWDEEYDRGKRKKVKRSSQISDNSNPFQIIAQQNVQEKQKNKKILNRGSGRQPFRI
The following text describes a protein:
Function:
Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for repression of transposons and neighboring genes in ovarian somatic and germline cells.
Subcellular Localization:
Nucleus.
Domain:
The zinc fingers are required for transcriptional silencing activity.
Sequence:
MVYCPYNKEHKMLRKKLQQHILKCRVIYKDTVELMVCPFNSSHLIPEPQFFQHTQSCEDRNIIVHYQTSAPAVLSEDTRHAKIESEENWDDDESVPDYDPQVYCSRANIVREPNGLFPAQRRAFIEQEKRRHFGEDYEEEKKPRKAKARADLRPTPYEHRRPYSRRQ
The following text describes a protein:
Function:
Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.
Subcellular Localization:
Secreted.
Sequence:
MSATLRLLCLMACCVALAVANRPNYGGSGYGASYGDVVKAAETAEAQASALTNAAGAAASAAKLDGADWNSLNRYGWEQGRPLLAKPYGPLDPLYAAALPPRSFVAEVDPVFKKSQYGGSYGENAYLKTDAKLGVVAI
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, and then the transfer of this prosthetic group precursor to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield the holo-acyl carrier protein.
Sequence:
MQHFFTTFSTEGSKISLEALLNAREERAILQQQLITQYGQTLLCITLTAMGGVKKNALLDYVFTKALENLTALFTQLNITAVKEIIRPLETGHEAYFVLPIDARTLKVLMIELEESIPLARLWDLDVFNAKGNLLSRTDFDLSPRTCLVCGENAKICARTHKHEIDEIVDKIQSLAQNHDFAEHIGEQVYLALIQEARLSPKPGLVDAINNGSHKDMNLHTFEQSAISLKPFFTQFVLKGMMTAHLSENQILSEIRPLGLLAEKAMFKVTDGVNTHKGAIFSFGLVCTAIGRLLAQKSLVQSAVDFDVKLICSLVAQFTQGLTDELKNYPEHLPSTAGVRLFQKYGLTGVRGEAENGFNLIQTLLPQFDEYHQLEWEHRLLILLLNLMAINSDTNVVHRGGLAGLYFIQQTAQDLLTDQHLVTDKTALTQALMKFDTACIERNLSSGGSADLLALTIFFLSFRGN
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MAERGAHLSQLLLDSSRPSIFELVAQEGLNQALRGTIKFVFRVCANHYPETFGLSFRWANEIQLLFDCFLQNYYLRNYGASFSENFYGLERVTKEDCTLNGKGSLHSLISLTILPYALSKLDAYFSERQQHNDQQRPVLNFSSIRFIYDLIVLVNWMLYTWGKSVTHSPILHLLGLKLKHGGDNSSPGISLTKIIELSAFFIQFLEWWFTNQSSQAKSMLSLPIPPPPHSIVQNQHSKPRIGVCPLCQQQWKNECVLRVSGYVYCYRCILPYLKENNKCPISKLPASPNDLIRIFANAE
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Subcellular Localization:
Secreted.
Sequence:
QLINGQGAPAPYPDPLEPKREVCELNPDCDELADQVGLQDAYQRFYGPV
The following text describes a protein:
Function:
Together with ehn-3, may play a role in gonadogenesis.
Sequence:
MSLSSLDAVLSLIATSSTLDQDSAKVPQCQVCKRKFANQKTLRTHMKHITCRPGRSNVVNHKFRCENCEKQFTNKPNLKRHQITHSGSKSKKCSTCQRTFFREDQLQRHLHNHLKERSHFDCPVLNCSMQFVFYEGVENHLVNHHHFSYSESAPCGKCHKLFGSPRHLLVHYHFDHKEALRSSAPAPTSSARLSPITVSTSGSPRAQLAISPQEKPPQKLSINLGTSPMIEEFCEQNSATLPNTDQQLSPTLSPNEPRFRNLITSEPTPSFECKHCTIKFHDATMSIMHNALHAPGSPFKCAICGAECGNKIVFTMHIITASHDFGGIGT
The following text describes a protein:
Function:
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs.
Subcellular Localization:
Secreted.
Sequence:
MGILKLPVVLIVLCVALNHLEGGGKPTESHQMEKRKCGTATCETQCLANFLAPSSNKLGAIFSPTKMGSNTYGKRKKVEILKREPLSYLPI
The following text describes a protein:
Function:
Has bacteriostatic activity against the Gram-positive bacterium M.luteus, but not against Gram-negative bacterium E.coli SBS363. Has fungistatic activity against C.neoformans, but not C.albicans. Binds and sequesters copper and iron ions. Copper-chelating is crucial for antimicrobial activity against M.luteus.
Subcellular Localization:
Secreted.
Sequence:
MKAIFVSALLVVALVASTSAHHQELCTKGDDALVTELECIRLRISPETNAAFDNAVQQLNCLNRACAYRKMCATNNLEQAMSVYFTNEQIKEIHDAATACDPEAHHEHDH
The following text describes a protein:
Function:
Negative regulation of glyA transcription and kinB-dependent sporulation.
Sequence:
MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKMEDNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDACYLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE