lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs) (By similarity). As part of the HAT module, involved in positive regulation of matings. Regulates septin ring assembly partially through the transcriptional activation of mid2. Also regulates the stability of the septin ring and is required for the recruitment of mid2.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MERNNGLGDYTYRYHGKELSLDDFQNKQGIESSDDAFLSKIYENVSNFNVPRKLHDIEHKFSKEEPSLILHIHKFHFRFEQQDGAFTYNGPVKSILQYIRMELIPPDCLEVFRNSDVKFYDGCLTVRIIDHRQSPSADQTVQPQPGSTNQQQQNNTNPINNQPEDTKPNTNSPPVYHTVLRPTPETLWQDLCLLSESFANSLSDEAVLTLESNILLASEAPLFLTPAKSKAEMIQFMNQLADSAPPCTRKKPQGSAQLADEEAERLEKENLLLLMDDQRKRDFQPTFQRLQFIENVRRKRAILQQRQMQMQQQQKAQQQQSPKAQQPPAHLVQSAPVQRKTTPKIQRLPPSSIQIPPPKPMQKFPANAASSESPPNATGNFLPSGPVPANEPMLKRESVDLIKIRQLAILFQQRASQLKARGATREQITEILNRQAIAAGTDLATVMTVARNLHFQQLQMRQQQQQQQMKAER
The following text describes a protein:
Function:
Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWTLPRTRFAHCNSSSSSDEKEIAVNIGGVRLVLCGDILNRYPDSRLAELVNCPTRSFDVISSLCDDYDPGKREFYFDRDPDSFKCIVEVYYFGEVHMKRGICPICFIKEMEFWKIDLSYLDECCKSNLTEKEEELAEIADKVKLILDDLECDPAVSRTERWQKFVWKLMEKPESSLPARVIAVVSFLFILISSVVMCLGTLPDLQVEDSEGNRVEHPSLDAIETACIGWFTVEYVLRLASSPNKLRFALSFMNMIDFLAVLPFYVVLVLTCLGTAMMELVNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYMGVGIFVFSALGYTMEQSHPETLFRSIPQSFWWAIITMTTVGYGDIYPKTTLGRCNAAISFLCGVIAIALPIHPIINNFVIYYNKQKVLETAAKHELELMELRALELTVRSASRRSDAPGRAWEGAMRASRSDTFIPLLSGAHRTEREPLKKKSLT
The following text describes a protein:
Function:
Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.
Miscellaneous:
MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 9.5, its MW is: 44.1 kDa.
Subcellular Localization:
Secreted.
Sequence:
GETISIYYDPGKFPALMPLKNGNYEERNGGVPQRGNITIHLQQFNEDLDKMTPDKNFGGIGVIDFERWKPIFRQNWGNTEIHKKYSIELVRYEHPKWSESMIEAEATKKFEKYARLFMEETLKLAKKTRKRAKWGYYGFPYCYNYTPNNPGPDCDAKAMIENDRLSWMYNNQEILFPSVYVRHELTPDQRVYLVQGRIKEAVRISNNLKHSPKVLSYWWYVYQDKMDIFLSETDVKKTFQEIVTNGGDGIIIWGSSSDVNSLSKCKRLREYLLNTLGPFAVNVTETVN
The following text describes a protein:
Function:
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the rad21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/cut2 protein. It is also required for pointed nuclear formation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSTRSIVTSKVSWTPEKFISALSYPEHCSITLVKRLKASVKLKDLKQNISRDAPSWTFEHLFVAFKCAVSNLAKQWAELSTTDKEKTRRMFCTPSRLNTAHRPEVFYLLECCTYILEQMQVVTKNTSHLYDCIRSGVSICNRLLDMEIFEPAISLLMKTHKNLIILLTYRDHDAIPTATLLNPTLDVSEIQLESCLFVPMVPASYFLNIGTIVVTFQLNVLRCLSLSQINGLSLNTINNLQSEDGPFQWIERSFPSQVQLANSRREILARLLTRFSMIQNNALQSFKLLILSIALWLNILSSQRADDKEFDVNQLETRILQLFSKVVQLCKSEDIEGSILNKDMTQLHHLLENLSKESRLHILLQLSQLYYKYNDFQLSAAYVIRGYSLSFEDISFKLKFLLFSFRLSIHDNSICFPFNLIQELSSLQQLFVENALPYSEALHLLDSIERSFRLFNDSTVFDDTVFALNISEILSWILSSVVRDILVEDELLNLQLKIRKFLMFTFHIIRSFSELTKFQSSLEGCLNLAAYYEDAEFPQKLSNHLYNLCVKSSNVNYARECISLSIKIAVSHKLTNDETYLLKILKNFQLRYHDSLQLQEKCDVLHTTFNQLDLYVGTTSVGKSSVLDNILKRIFNSLTSINDSNIEKLLESISYSLLKLFFKCANEGSRYNASAALSFKLSLMLHEKEEVLLLKTNVSCVLANHGYNDIKFEEMVLCVIKGDQNLLEHNSNNNAKLALNESLLCSWENLLCYRRAEDDSRILTIIESWTIFISRFSSVISRCSFTDFEINSILNFFFCFLHTVEPSGKLTFELAFLEIFYELFNCLLHLQFSKYLVIIGTLLSDKYMTLGFSGKAHLFYTKCYSYLRQCKSSPFINFWNVSYGKYLILTGNTDKGILQLKKYSLSSEEDFNSNGLSRTVSLNLLLYERIQLSDALFQLGYTTVSLGFIMQNLKVIKGLFSKSSKEHFNGGKYITWRLFAVSAHSNVCAARIYEHMGQAREAEFFYRQACSISEKMPFSCFSATFQLRLCSLLTRAGKLEKGEKILFDLTEAMKSTDTYHKLLWNYGAAEVCATKSELDGAICHYSECVKLLEIIKSEYYLFFNRNREKSLTKGIKRLSLSSQPTFVTESNTTEFDDWSILQNTAANLLRLISMFELKRGNLEIAKALMTDSTKCSIASFFNIVSANILKSKLIVCEADSTLFGDPVLRTLPDSVISLPGISHKFQKNQSKTKALGENTGFRKGSKRLDYLRERLKINLQNVRLSCEIIFSNAYERSSVCVCREVNELISYSTIMQSALTTIGETTDVDSSSASFFLEIPKALGFHRRREAQKFRNQHKELHFSSLEQILNSRLSIPDVRTFQDNFIDSLPSIWNVVSITINNSGEDLFISKIRKGHSPLIFRLPLQRHNSRDADEEILVFTKAQTELFRIISKSNQMAQNGKHYTRREDKETWWKERRHLDQCLQQLLENIEISWLGGFKGIFNPHKIDTSLFAKFSSQFQNIIAKNFNMDKKTPVPTLSPEILELFITLGKPGYEGYEQLLEDLIYFILDIFQFRGLHFAYDEIDTDQLSMDLQDALNAYFNNYVSEENRSHTVLVLDKSVHQFPWESLPCLNRQSVSRVPSLSILRDILSQSFVVNGEYVEVRKEAGSYILNPSLDLKHTQEMFEHKLVEGGWKGLIASQPSNRDFIKMLSGNDFFLYFGHGGGEQYTTSYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCPTLVANLWDVTDKDIDRFSLKMLESWGLFENKAPFVNSTSICTAVSESRSCCHLRYLNGAAPVIYGIPAYIIP
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Miscellaneous:
MISCELLANEOUS: The phosphoryl transfer proceeds by an in-line associative mechanism. The random sequential binding of shikimate and nucleotide is associated with domain movements that suggest a synergic mechanism by which binding of the first substrate may enhance the affinity for the second substrate; MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains: the CORE domain which forms the binding site for nucleotides, the LID domain which closes over the active site upon ATP or shikimate binding, and the substrate-binding domain which functions to recognize and bind shikimate.
Sequence:
MAPKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQVPSPSEAAT
The following text describes a protein:
Function:
Is a potent antagonist of neurogenic gene activity during sensory organ development. The expression of distinct cell fates by the trichogen (shaft) / tormogen (socket) sister cell pair depends on the level of H activity. A certain threshold level of H activity is required, below which both sister cells adopt the tormogen fate.
Subcellular Localization:
Nucleus.
Sequence:
MALLNDVTSVAECNRQTTMTDEHKSNINSNSSHSSNNNNNGSSSNNDNNSNDDAASSSNSKNNNTSNESSHSNNNTSSIIAEAAAKFLLKNGLNGSSSTSYPPLPPPLPANLSRTTTPTTTTTPSSSSSTASNGFLPHAKTPKSSSIMAASAAVAASVVGATASKPTIDVLGGVLDYSSLGGAATGSLPTTAVVAAAAGTAKIGKGSNSGGSFDMGRTPISTHGNNSWGGYGGRLQFFKDGKFILELARSKDGDKSGWVSVTRKTFRPPSAATSATVTPTSAVTTAYPKNENSTSLSFSDDNSSIQSSPWQRDQPWKQSRPRRGISKELSLFFHRPRNSTLGRAALRTAARKRRRPHEPLTTSEDQQPIFATAIKAENGDDTLKAEAAEAVEIENVAVADTTTNEIKIEKPDTIKGEDDAERLEKEPKKAVSDDSESKEASPGQQVEPQPKDETVDVEMKMNTSEDEEPMTELPRITNAVNGDLNGDLKASIGKPKSKPKPKAKLSSIIQKLIDSVPARLEQMSKTSAVIASTTTSSDRIGGGLSHALTHKVSPPSSATAAGRLVEYHTQHVSPRKRILREFEKVSLEDNGCVNNGSGGASSGGAGGKRSRAKGTSTSSPAGKASPMNLAPPQGKPSPSPGSSSSSTSPATLSTQPTRLNSSYSIHSLLGGSSGSGSSSFSSSGKKCGDHPAAIISNVHHPQHSMYQPSSSSYPRALLTSPKSPDVSGSNGGGGKSPSHTGTKKRSPPYSAGSPVDYGHSFYRDPYAGAGRPSTSGSASQDLSPPRSSPASPATTPRTVPKKTASIRREFASPSASSSSCPSPGDRSASPPERRHMQQQPHLQRSSPLHYYMYPPPPQVNGNGSAGSPTSAPPTSNSSAAAVAAAAAAAAAYIPSPSIYNPYISTLAALRHNPLWMHHYQTGASPLLSPHPQPGGSAAAAAAAAAARLSPQSAYHAFAYNGVGAAVAAAAAAAAFGQPAPSPHTHPHLAHPHQHPHPAALTTHHSPAHLATPKLTDSSTDQMSATSSHRTASTSPSSSSASASSSAATSGASSSAMFHTSSLRNEQSSDLPLNLSKH
The following text describes a protein:
Function:
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Sequence:
MSKVALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHSCNPKFHLHYGDLTDASNLTRILQEVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAIRFLGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYRESYGIYACNGILFNHESPRRGETFVTRKITRAIANIAQGLESCLYLGNMDSLRDWGHAKDYVRMQWMMLQQEQPEDFVIATGVQYSVRQFVELAAAQLGIKLRFEGEGINEKGIVVSVTGHDAPGVKPGDVIVAVDPRYFRPAEVETLLGDPSKAHEKLGWKPEITLSEMVSEMVANDLEAAKKHSLLKSHGYEVAIALES
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDSDSNTDKKFFFKKRRIDSYNYSDEEDNNSSMNSDMTYTNDALKTSSGNAPTISKLTKTYGIGAKLLSSMGYVAGKGLGKDGSGITTPIETQSRPMHNAGLGMFSNTNSSNYHSENEDYLSSEDEVVEGIEQVKFNKTSTEVLGEALLNDSGDMTIVRTLRELRLAGVQLPESILKELDPLNAVPKPKKDVVVEILQELLGIEKSLEAIRQRTSPLEVQVKEYYGQERLLSELEVTLRDESKHVSLYDKIGAILKLSDDELIDRLTSCLLRKELLIEFDLDHLEKPNDILDELTQIIELLAYRMDTTSKFLNRTQTTIFKVIYPKLKKFWEGFDMTKSKIDSAITLLLDFQQVLSFIGCKEHIMEEFVYPKLLQELDNWELHDEVDHVSPRIWVLDFMVLIDDKIKDTIVDKIEAKFFAYCKNWYHRESFCITNSDIIFIKELICERRYYKILCKEFLPKFLDELWERHNDPIYELEDWKEKQEWKEKDSGFFYFMKKLRSYTHYFHPKQYELMMRGTFNNINKILYQWHLYSTVEDLHKSKWWLNWLMNTVFEHSLPTEIELSEIRKSYNIFAMSHRYHLDKSTLDEDFDLRQGLRNLMETQVIDDISQSEQEPTYTVQNIPLGKVSSSFKDVVEDYCLEKGYLISKIPNRYTQLPYGRDQDCIVPLFEIRNGKKKMEVALKHDILWVEDSSGTFKPIYLWALDL
The following text describes a protein:
Function:
Intrinsically disordered and metal-binding protein. Binds to the divalent cations cobalt, nickel, copper and zinc, but not to magnesium, calcium, manganese or cadmium (Ref.8). Binding to metal ions decreases disordered state, decreases susceptibility to trypsin and promotes self-association. Can reduce the formation of reactive oxygen species (ROS) in a copper-ascorbate in vitro system.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAGLINKIGDALHIGGGNKEGEHKKEEEHKKHVDEHKSGEHKEGIVDKIKDKIHGGEGKSHDGEGKSHDGEKKKKKDKKEKKHHDDGHHSSSSDSDSD
The following text describes a protein:
Function:
Involved in apoptosis. May play a role in nuclear function controlling cellular proliferation coupled to mitochondrial biogenesis. Causes impaired growth when overexpressed.
Miscellaneous:
MISCELLANEOUS: Present with 6020 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion.
Sequence:
MAQSKSNPPQVPSGWKAVFDDEYQTWYYVDLSTNSSQWEPPRGTTWPRPKGPPPGVNNEKSSRQQADQAPPPYSSQSTPQVQAGAQAQQPRYYQPQQPQYPQYPQQQRYYPQQAPMPAAAPQQAYYGTAPSTSKGSGHGGAMMGGLLGVGAGLLGGAMLEHAFDDHNYDGPDTVVVENNYYGDDAGGSDGGFDDAGGFDGGFDDGFDGSDF
The following text describes a protein:
Function:
May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MKFFTASTLFLLAAQSLNSGVSASLSDPANTPTILADDIVHGYTPATYLSSVPTLLKRATTSYNYNTSSASSSSLTSSSAASSSLTSSSSLASSSTNSTTSASPTSSSLTSSSATSSSLASSSTTSSSLASSSITSSSLASSSITSSSLASSSTTSSSLASSSTNSTTSATPTSSATSSSLSSTAASNSATSSSLASSSLNSTTSATATSSSLSSTAASNSATSSSLASSSLNSTTSATATSSSISSTVSSSTPLTSSNSTTAATSASATSSSAQYNTSSLLPSSTPSSTPLSSANSTTATSASSTPLTSVNSTTTTSASSTPLSSVSSANSTTATSTSSTPLSSVNSTTATSASSTPLTSVNSTTATSASSTPLTSVNSTSATSASSTPLTSANSTTSTSVSSTAPSYNTSSVLPTSSVSSTPLSSANSTTATSASSTPLSSVNSTTATSASSTPLSSVNSTTATSASSTPLTSVNSTTATSASSTPLTSVNSTSATSASSTPLTSANSTTSTSVSSTAPSYNTSSVLPTSSVSSTPLSSANSTTATSASSTPLTSVNSTTATSASSTPFGNSTITSSASGSTGEFTNTNSGNGDVSGSVTTPTSTPLSNSTVAPTSTFTSSGFNTTSGLPTSSASTPLSNSTVAPTSTFTSSGFNTTSGLPTSSASTPSSNSSIVPTSTFTSSGFNTTSGLPTSSASTPLSNSTVAPTSTFTSSGFNTTSGLPTSSVSTPLSNSSAYPSSGSSTFSRLSSTLTSSIIPTETFGSTSGSATGTRPTGSSSQGSVVPTTSTGSSVTSTGTGTTTGVTEVTETSTFETTEIITSTIEPTTASGTGGGNPTAAPTNEPTVTTGTETTEGTATYTEPTTFTSTFSFTTTIIGGTTTIIPVNPGNPSSSVSAPPTTSFTPGPGGSGYPSYSNTTQGMNTTSIWNSSNSTIVSNVTATITGNVTITTGDLTTIDPTTFTSTYLSSGFQTVSNTTATSGSDDDVKTASTSSSTSYTSSSSSSSSTTSAASSKASVSMGLNGLMIAAVILLVA
The following text describes a protein:
Function:
Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSSFFSRIHSGAAMAAAAPPHVLVLCWLLRTACLAFPEEPGPLNFIPTEVVRRYPVFLGRPHRTWLRHEPLHIQRILQVNRTLYIGARDDLFRVELDTVVEEEMFYSKKRTWESNKNDIKICRMKGKHEDECRNFMKVLLRREEGLFICGTNAFNPLCANYTADTLEMVGDSLSGMARCPYDPKHANVALFAEGSLFTATVTDFLAIDAVIYRSLGDSPALRTVKHDSKWFREPYFVSSVEWGPHIYFFFREIAMEFNYLEKVVVSRVARVCKRDQGGSQRVLEKQWTSFLKARLNCSIPGDSHFYFNLLHSTSPIIRMHGRDIILGVFSTPANSIPGSAVCAFDMEQLAAVFDGRFKEQKSPESIWTPVPDEVIPKPRPGGCAVQGSKFNSSNSFPDEMLNFVKTHPLMDEAVPSLGQRPWIVRTMVRYQLNKIVVDTEAGPSRNRTVLFLGSNRGTILKFLIMPNQDNTVTSSNVFLEELEGFNPDRCAVDSPQARQMLSLALDRASRTLLLAFPSCVVRVPVARCQLHSRCMKNCIASRDPYCGWTRGSTCSFLRPGTRLPFEQDVEHGNVAHLGDCDGMLLQETFVDEPDGLVSVNLLVVSAVAAFSTGAILSGLTVCWIMSHRHRHSQGPRSGATRRKSDKEQSVLGQGHSGSVMSVTRTSGGDRRRSQPDSHFMMPNGWPKGEMDPGLLPTPEQTPLQQKRAVRLPDCDWDQSQTFLTSVGSSCPNGAVIYLSSKYLHGGVGGGGVVRIEDPGEVVLPPHIDRQRYLILATQRGEHGGSHATTGRNSAGEYIYPATPQESPDRRRVVSAPTPHMDYREPRWSQEALNYNCNNGAPYSSQRQGLIRPDMHGPRGLGDLVDFSHLLGKNMVERTPTGQ
The following text describes a protein:
Function:
Probably involved in transport through the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MRDQHEGENILLITPYLHIGKRTLHYNHIFTSSGYSLGLSSLHCYHGWQSYYQNLISYLSRPKSLLTALKLTLPTAKHHGMFSEYASKLLTQSQVKFGKDSNVPLFHSAVEEAESSNHNGHTNHNNNNHRGIYSPRRLWEHMEDDEEASNAINASWNSNSGSDSETEGPSNSFLRAVEEPGKSHKQPKESFFPVDFLDREDGQPEEVGKQLEDSEQSIEGEHFFPASTSAAAAAAGVPVDPEHGLNEDSMASSIPPELAPPTSVSDTIKYDQVWGGVYLFMLAATIATYLLALLRGVDGGAPTGSPSLTFLPLTVLAHYTVFAVAISLVWLLLLRKYSSVMFYFLAAAFPVAVWTAALVTLFSGGYSWWVTLGLMITGSMWPLAFWKHKDYVSRAVGIIQLSCRILSANHVLVFLSFAFMTLFVLISAICVTAIGQVMYGKNMLVSALGIFMYMWTWGILNGTQRATISATVSQWYFYRHLFPHTSSRQVLAAALGYALTTQFGSISLSSLLHLTFRIPVLLLSRVVSLSGTVTSVVAPWPLRMVLNVVSPALYILATPSGVLSMSPLTLTLAVINSQNLKSSSLTVQNLHFRLPAAAWRVHKLAKLLLVVVRVLTALLFAATTWVRGHLLWEVVLASFTGWFVLGSTEGLLSMIVDSIFVCFALDSAAQGGHCTEADVHFNGAHEY
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGPVMDAACVTYEGVSHEIETFPRTEEDVWILGKRYNILQGDMGYLNTDVRSRIWLTYRKNFPKIGGTGPTTDSGWGCMLRCGQMMLAQALVCRHLGRDWQWDPENNTTPEYMQILEAFLDKKDSLYSIHQIAQMGVSEGKAVGSWFGPNTVAQVLKKLSAFDDWSSLCLHVAMDNTVIIEDISNWRPLVLFIPLRLGLTEMNVVYNEPLKACFTFKQSLGIIGGRPNHATYFIGYFGNNLVYLDPHTTQQTVNPDELSRIPDGSFHCVYPCRMNIADVDPSVALGFFCKSEEDFDDLCQQIQKKIIDGKSRPMFEIAKDRPQHWPVLEIPTRPCDELNSSCQSDFTELTYEDEDRAYDTDGEYEIL
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGKPKLHYFNGRGRMECIRWLLAAAGVEFEEKFIEQPEDLDKLRNDGSLMFQQVPMVEIDGMKLVQTRAILNYIATKYNLYGKDMKERALIDMYSEGVEDLGEMIMHLPLCPPDQKDAKIAQIKERTTNRYFPAFEKVLKNHGQDYLVGNKLSKADIHLVELLYYVEELDPSLLANFPLLKGLKARVSSLPAVKKFLQPGSQRKPPMDEKNLEEAKRIFRIK
The following text describes a protein:
Function:
May catalyze the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).
Sequence:
MISRKALGSLVCLSAVATLIWIASGNWKVHYLPYYLPCPGIFSKKLQYLGDKPVQLFPQLFYQQPRVLAPKRQDVLTVTPWLAPIVWEGTFSPEILDSAYMPLNLTIGVTAFAVGKYTRFVSRFLKSAEMHFMKGYRVNYYIFTDNPKMIPDVQLQPGRRFDVVHIKKYSSWQEISVRRMEAINLHIAERSHREVDYLFCLDIDMVFHNAWGAETLGDMVAAIHPGYFNVPRSQFPYERRSSSAAYIPDGEGDFYYGGAVFGGLVKKVYEFTKICHMTILADKANGIMAAWQEESHLNRHFLTHKPSKLLSPEYLWDDRKPKPPEIFLIRFSTVDKNYQEVRN
The following text describes a protein:
Function:
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Domain:
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain (By similarity); The C-terminal coiled coil region mediates homodimerization.
Sequence:
MEGDNCNKSRHKSHNMINPNYASVRCTQPLPSVIQLRSRNKMIGITEDPSSDSEPVSSNQPLLLTNLSYEVHTFNDNNNHERPAPQEQSTQNTMISMQSEQKSDRFTASNLGMFQYMKFEIGEDGDDHEEEAILTNREKLRHILHSKPIHVAIIVLVVLDSFLVVGELLIDLKVIIVPHGNPAPEILHGFSLSILSIFMVEIALKIIADHRHFIHHKVEVLDAVVVVISFGVDIALIFVGESEALAAIGLLVILRLWRVFRIINGIIVTVKTKADDRVHEIKKKNSELELQIHNLEEKLSQKEQDMSRLHEILRCNNIDIPPTVPLTTSVQIHSTTTASADV
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSRRDVDEAALLKFYGISTPYPEHWEEVDHEKDGPLAGTGTLGEDGGASEVSDPLGLRGKLTGVTDLDIKTRAATSLSSKAFDPKIFLSAHHPDASYQDLQKGINNLERAIESRSEAVRILVEDNFDRFVAVKASSDVVYRDMKEEFLADESDHGIRELREIFKVAAHRADQVFLPVLENAVKASKLRSTLGVFEKSKFLFNLPGQLLESINARKYDLALRDYKKGLFLHNSRSGQLIPGVNASREQQKRVFDKVWSSVEEIMGDMRAKLDSGLKEASRGVEEQERTIEILVELDQSDEPAWTYLEYQHAHILSTMKIIYEKTQERARIAELECAREPSTSTAYLNLLRRQLSSPEYELNSLAPTTVDTAWLAIHFLVKQLSEYVARSFAGFWRIGKACMDGKYRKRDSSDSIVASNRPANTCRIMALEIVKLYNSLLSQFFKLSDPAIAESTPRKDSNHQLPSFVPAGTSVITACYFAEKLVEDISDCAGELAGHEVVNDSGNGMKGLVESMKWKMKEVIGAVWARDAKILHGLEDWSQATNPKGAIRYLTLVDEFQLRIISSVKKIAAIRKGDVESFSNVLKKRIKEDFVETQCHIYDGIMKATDVDLRDGSGADVEQRKKPLRGASMDVSVVQNPEIRLLVSLAKFNQMQETSIKAICRKVSKVLDVDMAKQQDLLLQVIEGMDARAFKVYISLRAEPLSKIIREAVLHDTDWVNAGKPAEIRPYIHKIILLLVEAHAQTGDIAPALVPRVIQALIESITRVALSCFQQIKKYGPGGMLTATVEIEYLHSVVSLYVSAQASDNLSQIYDTIGSVYGRQQSPEELSKEMDGLRKLLSATRKATGMETLCLRAPKD
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MGDVYVTSPTFVGHDTGSILAIDCHPSGKKFITCGQKARTSNGLVVVWNAEPVLDKKKASNENVPKLLFQVESQSQSNSCRWSPDGKRFAFGSDDSSVSVWEYVGLINSMGSITGGAQNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKLPDRITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTEPFESNIEETMLTRLDWSPDGKYLMTPAAVRSGKPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPRLIEANLKNGKRMQLTCAAVGSRDKSISIWVFPGTLKPLFVINNIFNHTVMDFAWCGRNLLACSQDGTVKVIHLSESVIGEMISNEAMSDLCYQIYSIRPPRYELTDKEEDESQDSFNLSDLSSSANNASFVTCPEDVLIKRKKLVAAQQSSDIQLTKSMEDNSKENESKNSEKTMMEERNKQIDVRKDGKRRIQPVFCGTTTADPMTSLSSEGKKTVAPPPAKRKALAPAVPAKKGEVDLEDSSDSDDDDEEEEEDMEISDIESVRNKKRKVPATTSQPMLALDLKKPALRPMEPKSLKTQEGTVLMEAPEQQPKLSQHVVDRKGMFVEIDNRWKHGGVETTQIKLIKKKQQTAENEDDMMDGERRVNHECLWMAVLGSPVIIVAANKHNVVLGCGDKCLRVYRTFCGTHIVSLRLDSLPVLIGVTEHAAYALTENGRLSTWNLKLGKAVVTRQPLFDCVEASTDNSLISADVSETGVPLIVFSNGSIFTFNVSLSCWIQAITTNVLGRLTSPISDAQLSCSNGTTNSAGPLVRLLKRMRKQATAPGVAPQVVKAVKESQLEQLLHCAEQLGNPQDYQTMLMLYVETLCEGGSEKKLKNILNDLSRSGAPMQVCGLRRSALYDDVTRMIKLKQPAIAARIVAGVAASTTTKSLF
The following text describes a protein:
Function:
Acts as a mechanosensitive calcium channel in response to membrane stretch (By similarity). Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock (By similarity). Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock (By similarity). seems to contribute to CaCl2 toxicityIn contracstz to mscA, mscB seems to contribute to CaCl(2) toxicity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
EF-hand domain is involved in the detection of calcium concentration.
Sequence:
MPNPNDVTIDIPLTSVSSRGQTGARNNSTNIPNSPSGGYSAGAEHNGGAEKGGLTSSPPSSSLGFGHRRRRTINDKTGLPAEEPEDGTVTRMGRFYQAVLNFSTVTRYLIYIAPLAALLAIPIIVGATAAEDAKIGGVSLPWFFCWVEVVWVSLWVCKLVAKVIPFVFQFVCGIVSAGTRKYALILRNLEIPITMVLWMIVSLVTFLPIMVYNPRNKREGDTETKSWEKSVKNVLFAFLVCALIFLGEKTLVQLISISYHRKQFDARIKESKRNINLIGILYDASRSMFPMYCKEFREDDAIISDSILLGGPETGRPGHSRSNSAAPLRFIRGVQQNVGRIGGKITGALGDVAHEITGKQVFNSSAARSIVSEALERRRSSEALARRIWMSFVIEGREALYLDDIMEVLGAGKEAEAEECFTMLDRDGNGDISLDEIILAISEIGRTRKTLNHSVHDVDQAIHVLDNLLATIAFIIAVLVFVSFVTSGFGTVIAAGATSLLSLSFVFATTAQEVLGSCIFLFVKHPFDIGDRVEIDSKPYIVQRISLLYSVFRNVNDNRVTQIPNVVLNTVWIDNYSRSSAMQEKLTIEVNIDTTTEEIQALKDEIETFVRSPDNKRDFHPDVDIEVSGVGALDKLELTVGLFHKSNWAIESVRAARRSKFMVALVAAVKKVPIRTPGAAAEDAAAADGDRPDDKPDDAEQPPARQSSISEGIRHPTVPDDSFPSDSKSTGVDLGRPGSVQRRGASATAATGNNSAGSAYSETTLNNTVSEPYQRSFTPNTGDRDTDHYHGSMSSPVTERHLGVSHDSIARKASTASTGRRRAGIMTTANQSLASPTTMQSESALPPHLQPPPPLQPSSSQYSQQYPQQQSQSPYSYTYSERYDQPESSLQPLEHTTSYNQSLPQVYEYAPAADRNSLEGHSPHVDPRHMTEEQRRNYESRRL
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MFQQLTYRLRLFRRRHKYIFINSIFLSVIIIFLIYSYWSNLPAEDNSAIINEKGTYHRSLWESITMALFPPKTKPFEEKKPQVNPNNNQEVGVESGASEISQHKQQQQQQQHAKEPTTKTSSKSLVSDEAYQLNLKLINEQQEKYNRLHPFEQKRLQQGYEFFDNIFKIFYQAKPSVSQLNTYPSKKRIYHARFDSLADDDTIFSEKYLSQFLQLSNEELAAMKKSHKYVVENLPEDAPDGLYKKNGIVYVAGGSFNWLTLLSIKSLRAVGCHLPIEVFIPKIEEYESDLCNRILPELDARCIYMKNQLMNPNKDNSDSFANKFEFKGYQYKALAILLSSFENVLLLDSDNIPAHSPEELFENDPFKSYGLVVWPDYWKRATSPYYYNIADIDVSEKYLGSKYNEVEGQYTDLSVEKGSVELDKIPLHQRLGSIPDPTSESGQLLISKKTHLKPLLLALYYNLYGPSHYYPLFSQGSDGEGDKETFLAATVTLGKRYYQVAKFLVSLGHFKVPGGDFEGCGMGQFDPQQDLEYIKLREQYAKIPEKDKEKQHKFKLQHQVLEKGPEILFVHANFPKLNPWKLKQEKKIFDAKGNRVRLYGPGMIKRIGYDFEWFQWEGMKYLLCIYDVNLQIFQDVKKSDLCDEILEHLRFLESTQNITD
The following text describes a protein:
Function:
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Also binds to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity).
Subcellular Localization:
Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface.
Sequence:
MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYVLCALLTITVAILGYKVVEKMDTVTDGMETSRQTYDNKLIAVESDLKKLGDQTGKKALSTNSELSTFRSDILDLRQQLQEITEKTSKNKDMLEKLQANGDSLVDRQSQLKETLQNNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQSQMYSQNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSLAIQQIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLEDMNNQLSSFTGQMDNITTISQANEQSMKDLQDLHKDTENRTAVKFSQLEERFQVFETDIVNIINNISYTAHHLRTLTSNLNDVRTTCTDTLTRHTDDLTSLNNTLVNIRLDSISLRMQQDMMRSRLDTEVANLSVVMEEMKLVDSKHGQLIKNFTILQGPPGPRGPKGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGTIGPVGPPGERGSKGSKGSQGPKGSRGSPGKPGPQGPSGDPGPPGPPGKDGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAMEPLALQNEPTPASEVNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVFINSREEQQWIKKQTMGRESHWIGLTDSEQESEWKWLDGTPVDYKNWKAGQPDNWGSGHGPGEDCAGLIYAGQWNDFQCDEINNFICEKEREAVPSSIL