lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. At anaphase, the rad21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of psm3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable rad21 protein, forming a ring structure (By similarity).
Sequence:
MGRLLRLEVENFKSYRGHQIIGPFEDFTSIIGPNGAGKSNLMDAISFVLGVKSSHLRSTNVKELIYRGKILQRDNTDFTDSSNPTTAYVKLMYELDNGEQREYKRAITPSGATEYKIDEEIVTFSEYCGSLQKENILVRARNFLVFQGDVETIASQSPLELSKLVEQISGSLEYKSEYDKSKDEQDKAVNLSAHSFNKKRGINAELRQYQEQKTEAERYQSQKEKRDSAQLVYLLWKLFHLEKSISSNMAEVTRLKADSIQLIERRDENTKEIEKLKEKEGSIRRNLLAFDRKVRKQEKLIASKRPELISIAEKALESKSNLRKIQRKAAEIEKDYSDQASTLQVLENQLTSLSAAEKEFLKDMQEKEQLKGLRLLPEDKEEYEGLRSEADKLNSNLLFKLQTLNRNIKVTSQSKDSLTSIVGDLESKIKSLHESVSSLDTERADLLAKINEKIESLELEKHDQQKKRLTYSELFHKTQELNEELQSCLQKILEASADRNESKQDAKKREALYALKRIYPEVKGRIIDLCTPTQKKYESAIAAALGKNFDAIVVETQAVAKECIDYIKEQRIGIMTFFPMDTIAASPVNQKFRGTHKGARLAIDVLNFESEYERVMISAVGNTLICDSMTVARDLSYNKRLNAKTVTLEGTVIHKTGLITGGSSNNRSAKHWDDHDFDLLTQTKDRLMHQIGEIEYQKSSCVITESDTVKLHSLESEISLLKDKYTVVSRSVEDKKKEIGHYESLIKEKQPHLSELEMELRNFVKSRDELQIQVEKVEEKIFSGFCKRIGISDIHTYDEIHRTFTQSFTQKQLEFTKQKSLLENRISFEKQRVSDTRLRLERMHKFIEKDQESIDNYEQNREALESEVATAEAELELLKEDFASENSKTEKILLAASEKKLVGKRLVSELTKLSGNITLLESEIDRYVSEWHAILRKCKLEDIDVPLREGSLTSIPIDDVSNSGDITMGEEPSEPVINFEKFGVEVDYDELDEELRNDGSESMASVLQEKLREYSEELDQMSPNLRAIERLETVETRLAKLDEEFAAARKAAKNAKERFNAVKQKRLQKFQAAFSHISEQIDPIYKELTKSPAFPLGGTAYLTLDDLDEPYLGGIKFHAMPPMKRFRDMDQLSGGEKTMAALALLFAIHSYQPSPFFVLDEIDAALDQTNVTKIANYIRQHASSGFQFVVISLKNQLFSKSEALVGIYRDQQENSSRTLSINLEGYVE
The following text describes a protein:
Function:
Needed for flagellar regrowth and assembly.
Sequence:
MSLNSRKNLIQKDHLNKHDIQKYEFKNMANLPPKTNPNSASLETPNLEEPLEKKAIENDLIDCLLKKTDELSSHLVKLQMQFEKAQEESKVLIENAKNDGYKIGFKEGEEKMRNELTHSVNEEKNQLLHAITTLDEKMKKSEDHLMALEKELSAIAIDIAKEVILKEVEDNSQKVALALAEELLKNVLDATDIHLKVNPLDYPYLNERLQNASKIKLESNEAISKGGVMITSSNGSLDGNLMERFKTLKESVLENFKV
The following text describes a protein:
Function:
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRTSDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN
The following text describes a protein:
Function:
Probable component of the mechanotransducer (MET) non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Note=Localized to the hair bundles of the hair cells.
Sequence:
MCVLQLGWKWMQNLIVEVMWTQKEEQKAGINQNLRREEGKPNQQTVWRRAKKRRMNRRARGEAGGRSKKMRMRVRKNRREEERKLSIPGREQQRKTSQRRRSPSSCSSSSDNNSDDESMSEGEMARLKEEVEEKKKLIATLRNKPWRMKRRLKCLKEAQEFVEKFEGALGKGKGRRLYAFKVMMTKKLIKFNRDFENFKTACIPWESRIKEVESHFGSSVASYFIFLRWMYGLNLVLFGFMFGLVVIPELLMGIPYGSIPRKTVPREEQDSAMDFSVLFEFGGYCKYSILFYGFYNNQRTIGFLQFRLPLSYLLVGVGIFGYSLMVVIRTMARNANEGGDGGDEGNFTFCWKLFTSWDYLIGNPETADNKFASTTTSFKESIVDEQENLKDENIHLRRFLRLLANVLILCCLAGSGYLIYAVVKRSQDFAKRDRNELTWLQKNEVEIVMSLLGLVCPPLFEAIAELEDYHPRIALKWQLGRIFALFLGNLYTFLFALFDEVNGKLENEKQIKNQTVWALKEYYANYTLQYNITENIPPPNIAPADVIRGPCWETEVGIEFVKLTVSDIQVTYLTILIGDFLRALIVRFLNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGAFYAPGLVGINVLRLLSSMYYQCWAVMACNVPHERVFKASRSNNFYMGLLLLVLFLSLMPVIYSIMTLPPSFDCGPFSGKDKMYDVITETIDKDLPPFMADIFSYASNPGLIISVVLLMVWLAIYYLNAVSKAYQNSNLELKRKMQMQRDEEKNRRNNKDSTNQVMKDLEDLLPNKSLIPPPSVEETEKPAEQPSKSSKVTGKPGAAASGKGVHVQKDVSLAAANPRAPVTRAPGPRQPGPLPGNPRGPPPGQGMGRGRGGPPPRR
The following text describes a protein:
Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cell membrane.
Domain:
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Sequence:
MVAPKSHTDDWAPGPFSSKPQRSQLQIFSSVLQTSLLFLLMGLRASGKDSAPTVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKENVTIMVKSYLGRLDITKWSYSLCISNLTLNDAGSYKAQINQRNFEVTTEEEFTLFVYEQLQEPQVTMKSVKVSENFSCNITLMCSVKGAEKSVLYSWTPREPHASESNGGSILTVSRTPCDPDLPYICTAQNPVSQRSSLPVHVGQFCTDPGASRGGTTGETVVGVLGEPVTLPLALPACRDTEKVVWLFNTSIISKEREEAATADPLIKSRDPYKNRVWVSSQDCSLKISQLKIEDAGPYHAYVCSEASSVTSMTHVTLLIYRRLRKPKITWSLRHSEDGICRISLTCSVEDGGNTVMYTWTPLQKEAVVSQGESHLNVSWRSSENHPNLTCTASNPVSRSSHQFLSENICSGPERNTKLWIGLFLMVCLLCVGIFSWCIWKRKGRCSVPAFCSSQAEAPADTPEPTAGHTLYSVLSQGYEKLDTPLRPARQQPTPTSDSSSDSNLTTEEDEDRPEVHKPISGRYEVFDQVTQEGAGHDPAPEGQADYDPVTPYVTEVESVVGENTMYAQVFNLQGKTPVSQKEESSATIYCSIRKPQVVPPPQQNDLEIPESPTYENFT
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MAQENQAVDNGLPCNAYLDTSLREDENMQHILKTFYSSIELLEADTEKALALQAERTLNTNEQIKLDSYLVYLNSTLFFIYLKLQGEDASNHAVMHDLRRTRDLLARDKKINDALAAPRLDMPAAKRFIAAGTHTRFVDMNGVMVSEKQYNKSKQETPK
The following text describes a protein:
Function:
Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLTRVKSAVANFMGGIMAGSSGSEHGGSGCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKVGTITSTPNRNSKRRSSLPNGEGLQLKENSESEGISCHYWSLFDGHAGSGAAVVASRLLQHHITQQLQDIVEILKNSAILPPTCLGEEPESTPAHGRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSAYNISGGCTALIVVCLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDDDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRVYDLSKYEHGADDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS
The following text describes a protein:
Function:
Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Golgi apparatus. Early endosome.
Sequence:
MAAAMIWWPRFLLLLCLTCKGSTFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPIKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCNQSNKPITLTVEQSRLVAERITEEYYVHLIADNLPVATRLELYSSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKTGEKSSCTLPEGANSLPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSLLYFGYTTLMVLSFWLLTGTIGFYAAYMFVRKIYAAVKID
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MKQTLPVLAHFEKSSDEIAKYFALKYGNNYHIIKQLQNQRKQIETPMLEAKRTLRTIEQECDGLKRSNSKQSERMKATSTFNFSRPGSQFDTFIQSTQHFDLNSGQLLLQNIKQIMESLSTKEDPPNFQLYWESVYMFKWEQYLLCFVRPLTQKIIQESIFLSDIVISFIQCQMKENLLNNSQEHQQEMIVLTKLLLENFCHFLKKILTQTKQQNTLVVQLQTKIDLILCKNNPCISFIQELKKNNSFIKTIIDKLLQNDNPNIQPVIITCRYQLSQIKSLDIQTSRPQLVNAIYLSTSVSQQPEQYQSPLKTLFKVPHQQQYVMHLRQSYSNLEPVEVPFIKTPFQHSLCVILDLDETLGHYNDKIGKFIRRPGLVELLQGIKEHCEIVIFTAGLQSYADHAIAELQCDEYIDYRLYRPHTTFNGNNFVKDISKVGRPLERTIIVDNTPTNYEQQQDNGLLVSTWIDQQEDKELFELKDLIIKIAQAKTKDVRKALKKYRDYISRHK
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
YAAKRDPWKNFDPAADYKQVVRMHEARGEARSKYLHNQRLQKLDHEKGGGEEEEDSLKVGDSKQVDFGKVEKRVRTTGGGSTGTVRNLRIREDTAKYLLNLDLNSAHYDPKTRSMREDPLPDMDPNEKFYAGDNGNRATGQALEFKQLNFHAREVFDKMGLDHVVDVQGAPSQAELLYRNFKINKEKLKSQNATKAAILKKYGNAAANTDDREVVLPRELLLGQTEVELEYDRAGRVVKQGAIIRIAKSKYEEDVCVNNHSSIWGSWWKDGRWGYNCCHQTLRNTYCTGDAGIEAAASDVTKANVHRKIESNQAATTASDNDEIIRAATWGSQVPDDLVLNQKKLAEALEKEDRNKNQERDERKRKYNVKWKDEVTAEDMEAYRMKRVHHDDPIKDFLH
The following text describes a protein:
Function:
May be involved in cytochrome c oxidase biogenesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MHPDLSPHLHTEECNVLINLLKECHKNHNILKFFGYCNDVDRELRKCLKNEYVENRTKSREHGIAMRKKLFNPPEESEK
The following text describes a protein:
Function:
Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Domain:
The GRAM and PH domains are required for the localization of ATG26 to the preautophagosomal structure (PAS) and are involved in autophagy (By similarity).
Sequence:
MRPFLDDAKRRVDRKLSARRQSLSASRFLPSALPDRLKDNHDAQVDFTAPPGGSGSREGHLQYMQQSIFGMIAAVGSRSDFHARFDESSDSDGETGQRPRKESSVRKGTSVSVNTSSLDPSQRSSSQTDGNSEKDLGTRGRRHRRTISDHKLLRPFMSNSKHEPDPSTGDEMPTVSPPSRPRSATPRAAPILSRMVEAQAQFDLKASSTERSQSSLNETGAKGPRDASVSPLSTRLMDMFGFDKPEKVLVEYACSLLQSMLLQGYMYVTEGHICFYAYLPKKSTVAIKSGYLHKRGRKNPKYSRYWFSLKGDVLSYYADPSNLYFPSGHVDLRYGISASLGDPKEKGREPRDFQVTTDQRTYYFRADSAMSAKEWVKALQKVIFRTHNEGESVKISFPIESIIDIEESPMVDFAETFKIRVIEDDDSYAIDEYFFTFFNSGREAFEFLKILINDQSLKISSQHLSPQPDRSPRSDRTRKSRNRWSLTSGTSRAETQRKRSASTSHMSLAHDIVKSSPATRHQDSSDSILNSFEQATESSAAWQSITDAAESASQILNRSDVFQSPTIYGLDRRPSGRERRGRRNSDETARSPSTRVNVGTGQQIDELDRRTDGNTSGREARDTTSESDQYTQDPTKSFSGAPSLNELVKAGVYPLQRAAGLAEYLRTRSKQMSNLLASESMGYIEKVSGMWTGGRKHYGEAEDVLPDDQDVDPEDKEDGCNYGDRFRAHFALPPTEKLQATYFAYLHRVLPLYGKIYVSQKKLCFRSLIPGTRTKMILPLRDIENVEKEKGFRFGYHGLVIIIRGHEELFFEFRTSDARDDCAVTLHQHLEAVKFMAESGLLAEQEQNESEAAMTEHRMLQEARYYDYGENDLRPLNESSELHPIFDDPRASIVNFKPAESLRITCLTIGSRGDVQPYIALCKGLLAEGHRPKIATHAEFEPWVRKHGIDFAPVEGDPAELMRICVENGMFTYSFLKEASQKFRGWIDDLLSSAWASCQDSDLLIESPSAMAGIHIAEALRIPYFRAFTMPWSRTRAYPHAFAVPEHRMGGAYNYITYVMFDNVFWKAIAGQVNRWRKNELGLKATTLDKMQPNKVPFLYNYSPSVVPPPLDYPDWIRITGYWFLNEGSDWTPPTALSEFIHRAREDGKKIVYIGFGSIVVSDPSALTKTVIESVLKADVRCILSKGWSDRLGDPASAKPEVPLPSEIHQIQAAPHDWLFSHIDAAVHHGGAGTTGASLRAGVPTIIKPFFGDQFFFGSRVEDLGVGICMKKLNVSVFSRALWEATHSERMIIRAQDLGARIRSEDGVATAIQAIYRDLEYAKTLARQRSIASSTPFSPTPSAKTAAEQDADDDVEDSEEWTFVGDDTDVEMSRRLRDRAISDADMLPDRLLANSVPGDSGPGRN
The following text describes a protein:
Function:
Positive regulator of sporulation-specific genes and of sporulation. Required for premeiotic DNA synthesis and meiotic chromosomal segregation. May act in a nutritional signaling pathway.
Sequence:
MKTEISTADSLRDPPSNGLKADSELVIREDIDQFLPSEVSSLGSDHQNDGEDSDTDSDNFLQDPEDDVDEESTGRGTVTTTSTSTESRGRPSSCIFVASLAAALSDDELCLSVTENFKKYGDLARVKVLRDNANRPYAFVQYNNDHDAKHALIRAQGTLLNGRRLRCEPAKVNRTLYLKNQQSIDFNEISQICEKFGGLEQIVPDRTDNQYTRRYTYPISSANSWFVQFVYRDDAIRAYANLRTDPNWIIEWAQNINVPKNYNLLHKSKFKSSKYHQNNGIINNDGSNNNDNNNSNNNNREDSRRNGDVIEEECGHVHGSDSEEKLTSDGIYDDEDKDSEITIDKRSIFVGQLDKETTREELNRRFSTHGKIQDINLIFKPTNIFAFIKYETEEAAAAALESENHAIFLNKTMHVQYKEVGGRHNRKFSGKNGGSNFNHHQFFSTRSGKTFTGPELNLAPPPINMYRKMSGGSQQESETMMPYMPMGPMPMGPPPPNAASLSDFDMFPPSYSTFMKGMMPLRRKSMPNSWSSPSSKSVNSENESVNGGDENSELPSEIPESSGRYNAANSFTTYNNSSAGNSNNNNNNNNSNSNKSQYKKRYARRSSYGYNEVPPKPYYFQPYYYHPMQYHMGPMGPLHPSQGSAGNHHPYMMVYPMSPPPPSGLDGSMIPPPINVSQSHAANHGSTHVHANEFISNDTGDINEDNKAYSLDY
The following text describes a protein:
Function:
May act as a positive modulator of hmr-1 function during epidermal morphogenesis. Required for proper localization of other junctional components, such as pac-1.
Subcellular Localization:
Cell junction, adherens junction. Nucleus.
Sequence:
MISSGWMQEMEPIPEEGTEADGSEWGAMSDTAKRTMRKKEVYTSEQINTLVSTVPKEAVPQEWLVENQVVDPEMATSYLTESLAGPTSARGSSYSYSYESHYDNPPEEEYEHFTNDDGVHQMQKVTRVTKVTTTRSVRQVPVQSPYSNIDFDSSGLPTPSPVIDRDPSLEMMARMGGASDHDSEDRSAPPPAPASRFLHEDSGIPSAPGVPDVVDAGIGEVTVVWSAPLQSNGGEVRGYQIEMREFPDGEWESMGVDHLLKDTTCRVTNLTSHEVQFRVSAYGRTGFGPASNPSLPVKIPISETDLATSAGAPLAPGRPTVIAVDGQGVLLEWTPPVADVHSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKNQDGLGHPSMSSGGVAIRPAAPQRHVPARKVSESVQPPGQPQMVEVGDDVVKLEWAPSVQNARYIVEYREVGDPEWHTANYDPIVQNGIQVEGLHRNSTYEFCVISIVDNIASQPSETSDIIHLRPTCNTSALRPAPNILEAPEFLEVDGDKITICWLPAQSQLPVMGYDVEFRDLQQDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNASGCSQPSPPSDFVHIEPSTNRFSSDTMESPHLGHHDVVKYVEAERFGAVPLLQEEMVRESPPLPERDDSPPPLRRANNNVQWRDPSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANKLAVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMLKPVILESATEILSQQVIAPVLAVGTSDPTRHFGSTLFKNSTGVLRNVSAASQQARRRLRDIPNLIEALVHFLTHAIQKSQVDSPTVENAVCLLRNLSYRIQEVVDPNYDPAAAHSSSSKNMKHVASPKPEKKKKDKEKKKDKNPKNIVTGPSVLWQPHVVKLYLKLLQDSSNIETLEASAGAIQNLAACQFPPSAEVRAAVRVEKGLPVLVELIRLPEDFVVCAVATALRNLAIDPRNRELIGKYALRDFLDKLPEPGSPRRSAISDQTIGAVLGILFEIVRSSAAYTKDVHELKGTDKLRALSRSYPTYSHRVCKYASQVLYVMWQHKELHDGFKRSGLKEADFYSGTARRGDSSTLARPISSQGRERPSMHQLDETLSSGGGYGTMESNNRAGTLRPASATSQTIQRRYDQVPRDGPVYSSVQKPSPRGGGGGGNIDDSWV
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence:
MWIRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRTYLEKVASGKLPINHHIIYQLQDVFNLLPDASLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKERKDDKEKEKSDAKKEEKKEKK
The following text describes a protein:
Function:
Required for the final endonucleolytic cleavage of 20S pre-rRNA at site D in the cytoplasm, converting it into the mature 18S rRNA. Involved in normal export of the pre-40S particles from the nucleus to the cytoplasm (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKLDPKALRYLSKDDFRTLVAVEMGMKNHELVPVSLICTIANLKYGGTKKSIQTLHKFKLLFHDGRNYDGYKLTYLGYDFLALKTLVSRGVCSYVGNQIGVGKESDIYIVANDDNQEMVLKLHRLGRVSFKTIKNNRDYLKHRKSASWLYLSRLAALKEFAYMKALYENGFPVPTPIDYNRHCIVMSRARGYPLTQIVQLRHPSKVYSDLMNLIVKLASYGLIHGDFNEFNILINDEEEITLIDFPQMVSTSHLNAEMYFDRDVTCIRVFFEKRFNFIGERWPKFKDCQNIHSLDVEISASGFTRDMEKEFQDLSKQQDDDEINNNDSDENDEDDDEDDDDDDENNDDDENNDNNIENENEENIKKSSKVNKKEVGKEIKKEEEENNNSEEEDEEEEEEEDSDSEESVEDNTPVIEEFKGLSLNKNRDFKFSNLKDEDQNAPIVLRKEFIENLDENQPTEPKKEKVELTEEEKQRRKEEKRQKMITDKVKRQLGKTMREKVSVRNNVKSRTKKEVQAHISSY
The following text describes a protein:
Function:
Has pectate lyase activity.
Sequence:
MDHHYFVLVILSLIFANMLPFLSAENENIIAGIEDYEDPNAGNANAGAAMEAYNPELLEASLQRNTSRSDRLECAESNPIDMCWRGKADWADNRQALVQCVIGFAKGTTGGAAGEIYTVTDPSDADGANPKEGTLRWGAAQKKPLWIIFEKDMVIVLKHTLVVTSDKTIDGRGARVEIAYGGGITIQEANNVIIHGISVHDVRVMDGFAGRSACDGDALTIKTASKIWIDHCDFSKGPDGLLDVTVGSTAVTISNNRFHDHDKVVLLGADDSHTEDKMMRATVAYNRFEETCTQRMPRCRFGFFQVVNNDYNKWKMYAIGGSANPTILSQGNRFVASDNPNTKKVLQRNYAEESEWKNWNWRSEKDVLENGAIFIASGVDPQLTPEQQEGMIEVAPGELVPQLTSSAGVLSCVVGQPC
The following text describes a protein:
Function:
Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability. Required for efficient primary cilium formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MAAAWQSPYLNVFKHFRVEEWKRSHKEGDVTTVMDKTLKGTVYRIRGSIPASNYLQLPRTGSQSLGLCGRYLYLLFRPLPRKYFVVHLDVATEENQVVRVSFSNLFKEFKSTATWLQFPFICGAAKGSLHDGKARASRRELVGAAPADTRWTCLVLDLHYVLSLYLSRRYSHLKSIKLCSNLLVKNVCTSDLLFEPGVTLSEAHRASPACHGATPMPRDMAFPVPKGGKWHDHYDYIRFPPDGSRLPYDSIQRSCSSPVAGGHNSEEPLGQLPQPVTLTKAVRDRLSLIQQITSPKAMPHRCPAAAGSIPEVHLAAPEALRVGDQEAEDGTLRGMGDSMRSLAVSDGGIHVYAHQRSKQAAHATHSGSEEGVHGKGPGADAPTSGRASRCRSFLPDPILKLRKVIGFGGCSTKWALWTHNSSAVVYPCHAVIVTLQIQTGEQRFFTGHTDKVSALAFNGSSTLLASAQEGPLGVLRLWDFPKGSCLAVFQTHLRAVLSLSFSYSGAVLCGVGKDGHGKTMVVVWNTAQVTHGGEVLVLARAHTDVDIQTLKIASFDDTRMVSCGRDSVRLWRVRNGVLRSCPVNLGEYHALEFTDLAFEEGHSAAREPDDRTLFICSRSGHVLEVDYKNVCVRSARRLLPAELQDGAGPGIAINSISISSTLCATGSADGYLRLWPLDFSAVVLEAEHEAPVSSVCISPDGHKVLCTTTARSLGYLDIQSRGYSTLMRSHEDSILAFSVDGVWKQMATVSRDNSIRVWDLVSMQQLYDFTAAAEMPCAVSFHPTQRILACGFDSGVVRTFSLTASDLLTEHKQHRTRIAGLTFSPDGNFMFSSCLQGTLALYSCVAQKSQVLRVLGNVVARDAGSGPDALVLSGDSRLLAFVGPSKYVVTVMEACSLDELLRVDISILDLNSTALDSAVRICFAPVSRGELLVSTSSNRILVLDAKTGRLVREVSPVHKLSCSSLALSKDARYLLTAGDKVIKVWDYRMRFDINFQVYIGHSEPVYQVAFTPDQQHVISVGDAIFLWDFLAVPAERSPPALARSSKSPLLPAAEKSSEKLKDVSDVPRQTIPLPLLSSPPCLDVSSVHPAGCQSIFSESDREEEACLPGRIAQNGGKDASVLMAEPARSEELIVVRPKVRPESCRPPAPSANEPKETRSPKSQCCVRPDSYRHFTPRFKASVLPQSFSAPPAGNEVLKLRAVIGYNGNGRGNMVWDPDTGFFAYTCGCVIVVEDLHSGSQNHWLGHVEEISTLAVSHDAQALASASGKRDGDSHCQICIWNTQDGICTARLFHHKTQVQAMAYSRDDRFLATVGDYNDQTLALWSTYTYELLSSTRISEPVHDVAFSPFSHREMACVGKGAIMFWLLEQHGADINLKVHRAPVPEVLGPVELTSLCYGADTLLYSGTNSGQVCVWDTETNSCFMTWEADEGEIGMLVCRCNRLVSGSNTKRIRLWAVGAMQELRLKGPKGRPSSVLLEHEITLDGTIVSMAFDDSLEMGIVGTTAGTLWYINWKESTSIRLISGHKSKVTEVSFSPDETLCATCGEDGSVRVWSLGRMELVVQFQVLNQSCHCLAWKPHPSFSWEAESQHVVAGYSDGTIRVFSISRTEMELKMHPHATALTAIAYSTDGEMILSGGKDGMVAVSSPRTGMTVRILADHKGSAITVLQCTRKQYHDFGVEGGELWLATSSDRRVSVWASDWLKDKCELLDWLSFPAPASPEGLGSLPPSLAAFCPWEHGTLVYVGFGMQKEALFYSLRKKQVVEKISLPYFATSLSLSPAARFMAVGFSERLLRLQRCPAGLPQDYAGHDDAVHLCRFAPAGRRLLTASHSAVLVWELLGA
The following text describes a protein:
Function:
Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Probably involved in the export and assembly of fimbrial subunits across the outer membrane.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MTIEYTKNYHHLTRIATFCALLYCNTAFSAELVEYDHTFLMGQNASNIDLSRYSEGNPAIPGVYDVSVYVNDQPIINQSITFVAIEGKKNAQACITLKNLLQFHINSPDINNEKAVLLARDETLGNCLNLTEIIPQASVRYDVNDQRLDIDVPQAWVMKNYQNYVDPSLWENGINAAMLSYNLNGYHSETPGRKNESIYAAFNGGMNLGAWRLRASGNYNWMTDSGSNYDFKNRYVQRDIASLRSQLILGESYTTGETFDSVSIRGIRLYSDSRMLPPTLASFAPIIHGVANTNAKVTITQGGYKIYETTVPPGAFVIDDLSPSGYGSDLIVTIEESDGSKRTFSQPFSSVVQMLRPGVGRWDISGGQVLKDDIQDEPNLFQASYYYGLNNYLTGYTGIQITDNNYTAGLLGLGLNTSVGAFSFDVTHSNVRIPDDKTYQGQSYRVSWNKLFEETSTSLNIAAYRYSTQNYLGLNDALTLIDEVKHPEQDLEPKSMRNYSRMKNQVTVSINQPLKFEKKDYGSFYLSGSWSDYWASGQNRSNYSIGYSNSTSWGSYSVSAQRSWNEDGDTDDSVYLSFTIPIEKLLGTEQRTSGFQSIDTQISSDFKGNNQLNVSSSGYSDNARVSYSVNTGYTMNKASKDLSYVGGYASYESPWGTLAGSISANSDNSRQVSLSTDGGFVLHSGGLTFSNDSFSDSDTLAVVQAPGAQGARINYGNSTIDRWGYGVTSALSPYHENRIALDINDLENDVELKSTSAVAVPRQGSVVFADFETVQGQSAIMNITRSDGKNIPFAADIYDEQGNVIGNVGQGGQAFVRGIEQQGNISIKWLEQSKPVSCLAHYQQSPEAEKIAQSIILNGIRCQIQ
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane. Lipid droplet.
Sequence:
MRGQLCLVKGWLSAGEGWLAGPERSRGRMDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIVNSRKPQGWRLVARRTNHVIRRLELSVPPRLPQLWGGRRGWRFCSVTKGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSHREEGHGGGACGGYCSVL
The following text describes a protein:
Function:
Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Subcellular Localization:
Secreted.
Sequence:
MLLIRCLEKAMLIIVLWSLCSFLFLEGLPISKRSISEVQLMHNVREHKEMLDRQDWLQLKLNNIIIPSVNDSQKERKGKTNGPSVKRLRKGEGATWSFY
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Sequence:
MSRPFIPMTAKWRQEFIKPRGPANVPAVGSEAPDFTLPYAQFLSGPPEDRVEYGRTITLSALRGRPVVLNLTRIVSDRFFUPHCAPQLDALREHYDLFVQRNAHLLVVSSTDLEMTSYVAEVLRAPYPILSDPEWGVFYRYGMGSAMGVPLPGVFVIDADGIIRWSWAAPLSVVFTPPRPAELAAVLDALASEG
The following text describes a protein:
Function:
Required for the synthesis of BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) autoinducer molecules which bind to RhlR and thus acts in elastase biosynthesis regulation.
Sequence:
MIELLSESLEGLSAAMIAELGRYRHQVFIEKLGWDVVSTSRVRDQEFDQFDHPQTRYIVAMSRQGICGCARLLPTTDAYLLKDVFAYLCSETPPSDPSVWELSRYAASAADDPQLAMKIFWSSLQCAWYLGASSVVAVTTTAMERYFVRNGVILQRLGPPQKVKGETLVAISFPAYQERGLEMLLRYHPEWLQGVPLSMAV
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins.
Sequence:
MNSSIKRLHKEYASFQAGDISGLLLLKPVTDVDMFHWKAVIEGPTETPYEGGQWVLDIHVHEGYPISPPSVYFQTKIVHPNISWTNGEVCMDILKTHWSPAWSLQSACLAIISLLSNYDASSPLNVDAAKLLRTGDKTAYNSLVRCTTYLYAKGKIEDLS