lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in arbuscular mycorrhizal (AM) symbiosis with AM fungi.
Sequence:
MAINTSRTQILFITIISFLILAQNVNSAAFTVSNFDPYKTNIELEGNAFISDGSIHLTNVIPNSAGRASWGGPVRLWDADTGNLAGFTSVFSFEVAPAGPGLIGDGITFFIAPFNSHIPKNSSGGFLGLFNAETALNTYQNRIVAVEFDSFGGNSGGNPWDPAYPHVGIDVNSIASVTTAPWKTGSILTGFNAIAFVNYEPVEKNLSVVVRYPGGNFVNGTSNSVSFIIDLRTVLPEWVRIGFSGATGQLVELHKILSWTFKSSFQ
The following text describes a protein:
Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to exon skipping.
Subcellular Localization:
Nucleus.
Sequence:
MSGFSPELIDYLEGKISFEEFERRREERKTREKKSLQEKGKLSAEENPDDSEVPSSSGINSTKSQDKDVNEGETSDGVRKSVHKVFASMLGENEDDEEEEEEEEEEEEEEETPEQPTAGDVFVLEMVLNRETKKMMKEKRPRSKLPRALRGLMGEANIRFARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYRRILNLLSPSDGERFMQLARDMAKSYYEANDVTSAINIIDEAFSKHQGLVSMEDVNIAAELYISNKQYDKALEIITDFSGIVLEKKTSEEGTSEENKAPENVTCTIPDGVPIDITVKLMVCLVHLNILEPLNPLLTTLVEQNPEDMGDLYLDVAEAFLDVGEYNSALPLLSALVCSERYNLAVVWLRHAECLKALGYMERAAESYGKVVDLAPLHLDARISLSTLQQQLGQPEKALEALEPMYDPDTLAQDANAAQQELKLLLHRSTLLFSQGKMYGYVDTLLTMLAMLLKVAMNRAQVCLISSSKSGERHLYLIKVSRDKISDSNDQESANCDAKAIFAVLTSVLTKDDWWNLLLKAIYSLCDLSRFQEAELLVDSSLEYYSFYDDRQKRKELEYFGLSAAILDKNFRKAYNYIRIMVMENVNKPQLWNIFNQVTMHSQDVRHHRFCLRLMLKNPENHALCVLNGHNAFVSGSFKHALGQYVQAFRTHPDEPLYSFCIGLTFIHMASQKYVLRRHALIVQGFSFLNRYLSLRGPCQESFYNLGRGLHQLGLIHLAIHYYQKALELPPLVVEGIELDQLDLRRDIAYNLSLIYQSSGNTGMAQTLLYTYCSI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Subcellular Localization:
Cytoplasm.
Sequence:
MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKETLLAGHLQCSPEQAVELCALLAQTKFGDYNQNTAKYSYEELCAKELSSTTLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFCPINRIAYPVVQMATQSGKNVYLTVTKESGNSVVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRSDHSPPNSPLKSSESSMNCTSCEGLSCQQTRALQEKLRKLKEAMLCMVCCEEEIDSTFCPCGHTVCCEGCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI
The following text describes a protein:
Function:
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus. This function is crucial for viral infection of non-dividing macrophages. May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions; During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.
Miscellaneous:
MISCELLANEOUS: HIV-1 lineages are divided in three main groups, M (for Major), O (for Outlier), and N (for New, or Non-M, Non-O). The vast majority of strains found worldwide belong to the group M. Group O seems to be endemic to and largely confined to Cameroon and neighboring countries in West Central Africa, where these viruses represent a small minority of HIV-1 strains. The group N is represented by a limited number of isolates from Cameroonian persons. The group M is further subdivided in 9 clades or subtypes (A to D, F to H, J and K).
Subcellular Localization:
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Sequence:
MEQAPEDQGPQREPHNEWTLELLEELKNEAVRHFPRIWLHGLGQHIYETYGDTWAGVEAIIRILQQLLFIHFRIGCRHSRIGVTRQRRARNGASRS
The following text describes a protein:
Function:
Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSLHRTLRRFLRKWKALVYAVSFILLIQAFFTFQSSPNLMEEEHLRRLKELQIKKHQELANSMLQGERALVHGRDKLVLNPRDPGFREEFFKHSNNEINILEDHNIGQVDKMEKPVLKPNENKFEEIHFATEKVPEIIVKYQPKCDITIKDSISALSRATTDRCKQQIADAACKMQDGTLFPKSMPRTCKHESKFTFDAPMPTSFDPDIRPVRICYMLVVHGRAIRQLRRLLKVIYHRDHYYYIHVDKRSDYLLREVLKETEQYPNIKVAPWRMATIWGGSSLLQTLLRAISDVLRIWKDWDFFINLSALDFPIEKDEKLVQYLSKYRDKNFMKSHGREDEKFIRKQGLNRVFVECDQHMWRLGERQLPEGITVNGGSDWVALNRRLCDFAVNGNDQLLTQLKHWYEYTLLPAESFFHTLVQNSDLCETFVDNNIRVTNWNRARGCKCQYKHIVDWCGCSPNDFYPSDLVRLRTSRPVFFARKFEESINQEVVNHLDFKLYGDYPPGTPALHSLWENALRVNSKMPSDCNLSVVSMLQVEMHKKDEEFVGYVVTFDAGWVGRRGAGDDPATSEDGSRVQLQAFLSPQPSLRILDRSSNLAKRLETASVGTNWDVKELVIRDWGGLVGPNSDVHLVARWSRSEDDFVVTVVVIDPLNVVADYNDFRTPSKAAGVTETPLSLKKPLRPGRWLVRFYVQRQFTNICAELDFYVTPQEFKGGIEGDSVLREINRGVVDDAQVNAANRNLYSIRTTLNLARNNQAETELASESNHVAGLKLRNWVDFVVSSGWKAKDACLVAQSPETWREAQPRRCFMPRQGTPNLCENTNWSSLSPDPKTELISVKPDGRIR
The following text describes a protein:
Function:
Involved in primary piRNA biogenesis in germline cells.
Subcellular Localization:
Cytoplasm. Note=Localizes to Yb bodies.
Sequence:
MIKISDEKTWQSSRDSVYEVGDSYSGQNANRPLVATNCSEYAVAHANCQLRPVRRFAEVSLLPDILETMRNLGLNRLLRLQSYTWPHLAGGSGHGAMIVGSPASGRTFAYIPPVCHAVSRALMDFTGQCEDVEHDISQPDRYGPIALILVPDLRRVHQVSAMCLALLRKAHKNDSVTLALNVSSTKSSQFFLKLLNGVGCLVATPAQLVWFWQEAPGLMRFPCLQFLVYDDVDLMSREQLQDVQQVLQEILPLSHSPQVVMVSKSYCHTLMSKLRAVNDKPALVFGDILEAALYGGTRIRISIMRSEAKANAVVQMLQQCSPEEFRTVIFCSDDGDMQCLVAALEVQHYSCLPYYQTADLEVRQQVHSWQARSNGVILLCTDNCPELDIRDAHTIIHHSMSHSWSKFKLRHLKISDNLCNMVKPTASIVKKPLYSLVLLDDNNHRQLPRLVDFLQLHQKVDHRLVEVAKRIRQELGKARNDQHQLCDQILVLGKCYDPVCESRHRLSHIDRRPDYLPASGDVKVQLVKVYSPTHFCVRLLEHLPPKGTWRMMEYSAVQEFRMQLTQIKEPRRYWPPVAGAICMYHTTFTKERVRVLKVAAIKNTNIVQSDLTVKLQALDVDTRIFSTNCGKLFECPEALQQEAPLACDLRLPGWVPYFGERSWTEENIRNVNLILTQLPKDHFLQAKILFVAAGTLFVQDLVAIMYADQFKAHVRHLSLARRLVEATLVKRSENAAEMIREFFAEVIIEDDIDENVQDSKEKANSKPHEKMKGKMTDQPAKLQSQPPLSGRCLRLANMAHESVKENQLHQELQERRYETPEIPHQSNESDIPQSNEDRFSQLYECIMNCASLQLEDESKPAKHPDHVLSESVEFHKIMTNEDATPDHTQEKTALLLLPNNVARPSVTYYQTMTTLEFQVFLPEDDHDYKALLLGAQLFFRAISKSSDLILQFIMTLRFPYSSMSHNIRGRTVYISVKKLLALIDPLAFREYRFLKPNHDLFDKVDKQLQETQNRLVRFLEDMNYVKRNFEGQEKRETSEDEEVNVEGIERPDCHKIWDL
The following text describes a protein:
Function:
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular Localization:
Cytoplasm.
Domain:
Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
Sequence:
MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETIFTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENEDEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEALEALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK
The following text describes a protein:
Function:
Processive glycosyltransferase involved in the biosynthesis of both the non-bilayer-prone beta-monoglycosyldiacylglycerol and the bilayer-forming membrane lipid beta-diglycosyldiacylglycerol. These components contribute to regulate the properties and stability of the membrane. Catalyzes sequentially the transfers of glucosyl or galactosyl residues from UDP-Glc or UDP-Gal to diacylglycerol (DAG) acceptor to form the corresponding beta-glycosyl-DAG (3-O-(beta-D-glycopyranosyl)-1,2-diacyl-sn-glycerol), which then acts as acceptor to give beta-diglycosyl-DAG product (3-O-(beta-D-glycopyranosyl-beta-(1->6)-D-glycopyranosyl)-1,2-diacyl-sn-glycerol). Dioleoylglycerol (DOG) is a preferred sugar acceptor than 3-O-(beta-D-glucopyranosyl)-1,2-dioleoyl-sn-glycerol.
Miscellaneous:
MISCELLANEOUS: The local lipid environment around the enzyme affects both the extent of head group elongation and total amounts of glycolipids produced.
Subcellular Localization:
Cell membrane.
Sequence:
MDKLVSILVPCYKSKPFLKRFFNSLLKQDLNQAKIIFFNDNVADETYEVLQKFKKEHNNLAIEVYCDKQNEGIGKVRDKLVNLVTTPYFYFIDPDDCFNNKNVIKEIVESIKKEDFDLGVLKSMVYLCFLKHDFIIKFLPLKGIFQGRVKLINNNNVNKLNYIKNNDQYIWNIVINTDFFRKLNLTFESRLFEDIPIWYPMFFSSQKIVFIDVIGTNYFIRNDSLSTTISAPRYLNLIQCYEKLYVNLSQNGSLASFIDPNHKIEARFWRRQMFVWFALFSFEYFKKNFSESKKILEKLFVFLEKNGVYERVFQTKNQGIYYIWVQRLKYFKHVLESKSDN
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALELGVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQLNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTIIEQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNEISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVKTFFTIGIFFALTPFSKKPTKLERFYSILVFIVCNIGTIVTLNFRKSLYMRLRPLQATLWLFSDLTRYGHLVHIFVVLTWFKRKNWFKLVKNMQKIGTPVRGKHDLGIFVLAHFGFLAIMGLMLYGCFGALGAECLKLYQVENYEFYSQFFYMLFACFVLKLVLRRYNLQKRKLLETKFDMIRLRNVKNDLITLRATLDVFNDVFGAVILWNILYISAKSLIYLDNITKQELAFKKAGPGVNNNLFYCIQCGIMTIFWGSIVTIVILSQRILAQFDDILKVLDGINLNSKKLDNTTTNMKKIIQDVKNNRPKITASRFFQINKLLLFKIVNTFITFFLVLVQFDTK
The following text describes a protein:
Function:
Probable transcription factor involved in the regulation of flowering time under long day (LD) conditions. Functions as a repressor of flowering. Controls flowering time by negatively regulating the expression of HD3A. Acts downstream of the phytochrome B to repress the expression of EHD1, an activator of the flowering promoter genes HD3A and RFT1. Controls photoperiodic flowering response. Seems to be one of the component of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. The particular coordinated sequential expression of PRR73, PRR37, PRR95, PRR59 and PPR1 result to circadian waves that may be at the basis of the endogenous circadian clock (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMGTAHHNQTAGSALGVGVGDANDAVPGAGGGGYSDPDGGPISGVQRPPQVCWERFIQKKTIKVLLVDSDDSTRQVVSALLRHCMYEVIPAENGQQAWTYLEDMQNSIDLVLTEVVMPGVSGISLLSRIMNHNICKNIPVIMMSSNDAMGTVFKCLSKGAVDFLVKPIRKNELKNLWQHVWRRCHSSSGSGSESGIQTQKCAKSKSGDESNNNNGSNDDDDDDGVIMGLNARDGSDNGSGTQAQSSWTKRAVEIDSPQAMSPDQLADPPDSTCAQVIHLKSDICSNRWLPCTSNKNSKKQKETNDDFKGKDLEIGSPRNLNTAYQSSPNERSIKPTDRRNEYPLQNNSKEAAMENLEESSVRAADLIGSMAKNMDAQQAARAANAPNCSSKVPEGKDKNRDNIMPSLELSLKRSRSTGDGANAIQEEQRNVLRRSDLSAFTRYHTPVASNQGGTGFMGSCSLHDNSSEAMKTDSAYNMKSNSDAAPIKQGSNGSSNNNDMGSTTKNVVTKPSTNKERVMSPSAVKANGHTSAFHPAQHWTSPANTTGKEKTDEVANNAAKRAQPGEVQSNLVQHPRPILHYVHFDVSRENGGSGAPQCGSSNVFDPPVEGHAANYGVNGSNSGSNNGSNGQNGSTTAVNAERPNMEIANGTINKSGPGGGNGSGSGSGNDMYLKRFTQREHRVAAVIKFRQKRKERNFGKKVRYQSRKRLAEQRPRVRGQFVRQAVQDQQQQGGGREAAADR
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II GmuABC PTS system is involved in the transport of oligo-glucomannans such as cellobiose or mannobiose.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIA type-3 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-3 domain.
Sequence:
MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEADALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEMLDLFKTKNI
The following text describes a protein:
Function:
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
Subcellular Localization:
Cytoplasm.
Sequence:
MATVPVGAGSAPGPEPADLHAVPMVALNYGVRRRLGLYLNPRAATAADWTALAEKLGHDYLEIRRLEALPDPTAALLEEWQSRCPGGATVGQLLELLRQLGRHDVLLELGGSVEEDCKKYLRRKQQEAEQPLQVPAVDSSVPKTSELMGITTRDDPYGHGTEMFDAFICYCQKDLQFVQEMIRELEQTEFKLKLCVFDRDVLPGTCVWSISGELIERRCRRMVVVISDDYLESDECDFQTKFALSLSPGARLKRLIPVKCKTMKNEFPSILRFITICDYTNPCTKKWFWTRLAKSLLLP
The following text describes a protein:
Function:
Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state.
Sequence:
MTDFLIAFGSQTGQAETIAKSLKEKAELIGLTPRLHALDENEKKFNLNEEKLCAIVVSSTGDGDAPDNCARFVRRINRNSLENEYLKNLDYVLLGLGDSNYSSYQTIPRKIDKQLTALGANRLFDRAEADDQVGLELEVEPWIEKFFATLASRFDISADKMNAITESSNLKLNQVKTEEEKKALLQKRIEDEESDDEGRGRVIGIDMLIPEHYDYPEISLLKGSQTLSNDENLRVPIAPQPFIVSSVSNRKLPEDTKLEWQNLCKMPGVVTKPFEVLVVSAEFVTDPFSKKIKTKRMITVDFGDHAAELQYEPGDAIYFCVPNPALEVNFILKRCGVLDIADQQCELSINPKTEKINAQIPGHVHKITTLRHMFTTCLDIRRAPGRPLIRVLAESTSDPNEKRRLLELCSAQGMKDFTDFVRTPGLSLADMLFAFPNVKPPVDRLIELLPRLIPRPYSMSSYENRKARLIYSEMEFPATDGRRHSRKGLATDWLNSLRIGDKVQVLGKEPARFRLPPLGMTKNSAGKLPLLMVGPGTGVSVFLSFLHFLRKLKQDSPSDFVDVPRVLFFGCRDSSVDAIYMSELEMFVSEGILTDLIICESEQKGERVQDGLRKYLDKVLPFLTASTESKIFICGDAKGMSKDVWQCFSDIVASDQGIPDLEAKKKLMDLKKSDQYIEDVWG
The following text describes a protein:
Function:
Activates erythroid-specific, globin gene expression.
Sequence:
MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPSLLQDELLFLGGPASSAYALSPFSASGGWGRAGHLHPKGRELDPAAPPEGQLLREVRALGVPFVPRTSVDAWLVHSVAAGSADEAHGLLGAAAASSTGGAGASVDGGSQAVQGGGGDPRAARSGPLDAGEEEKAPAEPTAQVPDAGGCASEENEVLREKHEAVDHSSQHEENEERVSAQKENSLQQNNDDENKIAEKPDWEAEKTTESRNERHLNGTDTSFSLEDLFQLLSSQPENLLEGISLGDIPLPGSISDGMNSSAHYHVNFSQAISQDVNLHEAILLCPNNTFRRDPTARTSQSQEPFLQLNSHTTNPEQTLPGTNLTGFLSPVDNHMRNLTSQDLLYDLDINIFDEINLMSLATEDNFDPIDVSQLFDEPDSDSGLSLDSSHNSTSVIKSNSSHSVCDDGAIGYCTDHESSSHHDLEGAVGGYHPEPSKLCHLDQSDSDFHGDLTFQHVFHNHTYHLQPSAPESTSEPFPWPGKSQKIRSRYPEDTDRNLSRDEQRAKALHIPFSVDEIVGMPVDSFNSMLSRYYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLEDDVCNLQAKKETLKREQAQCNKAINIMKQKLHDLYHDIFSRLRDDQGRPVNPNHYALQCTHDGSILIVPKELVASGHKKEARKRK
The following text describes a protein:
Function:
Activates expression of the rhaSR operon in response to L-rhamnose.
Miscellaneous:
MISCELLANEOUS: Its activity is regulated by L-rhamnose. When this sugar becomes available to the cell, basal-level RhaR binds L-rhamnose and becomes activated.
Subcellular Localization:
Cytoplasm.
Sequence:
MAHQLKLLKDDFFASDQQAVAVADRYPQDVFAEHTHDFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYASVNDLVLQNIIYCPERLKLNLDWQGAIPGFNASAGQPHWRLGSMGMAQARQVIGQLEHESSQHVPFANEMAELLFGQLVMLLNRHRYTSDSLPPTSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWRHLNSQKD
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the activated spliceosome (By similarity). Plays an important role in embryonic brain development; this function does not require proline peptide bond isomerization.
Subcellular Localization:
Nucleus. Nucleus speckle.
Sequence:
MSAAIAALAASYGSGSGSESDSDSEGSRCPLPAADSLMHLTKSPSAKLSLTVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSSVPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD
The following text describes a protein:
Function:
Probable 3'->5' exoribonuclease involved in the regulation of cuticular wax biosynthesis. Can perform exosomal functions and partially complement the yeast rrp45 null mutant.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Excluded from the nucleolus.
Sequence:
MEGRLNNMWRLTVNESKFVESALQSELRVDGRGLYDYRKLTIKFGKEYGSSQVQLGQTHVMAFVTAQLVQPYKDRPSEGSFSIFTEFSPMADPSFEPGHPGESAVELGRIIDRALRESRAVDTESLCVLAGKLVWSVRIDLHILDNGGNLVDAANVAALAALMTFRRPDCTVGGDNSQDVIIHPPEEREPLPLIIHHLPIAFTFGFFNKGSILVMDPTYVEEAVMCGRMTVTVNANGDICAIQKPGEEGVNQSVILHCLRLASSRASATTKIIRDAVEAYNRERSSQKVKRHHTLAKSEVLGPIVVV
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MANRTIIAFDFGTKSIGVAIGQEVTGTARALTAFKAQDGTPDWQQVEKLLKEWQPNLVVVGLPLNMDGTEQPLTARARRFANRLHGRFGVQVALQDERLSTVEARANLFDRGGYRALDKGSVDAASAVIILESWFDEQAG
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MVTQEQRRRQLAREKFLRQQQRRTSARRKARMRNAAIASVLGVILIGSVALYTTGVVLGDDDDKTNAGAEVTPSASAPSKAPDPCDKPADGKVKTQTWKKEPAMTVDKSAKYTMKLATTCGDIDLALKADAAPHTVNSFDFLAGKGYFDHTKCHRLTTEGIYVLQCGDPTAQGNGGPGYNIPDENLKDKSLKDNVYPAGTVAMANTGQPDSGGSQFFLVYQDSQLPPSYTPFGTVSKEGMTVLKKIASAGAQPADPTTGNTAPNATVVIDKATVSKS
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGLRNSGNSDKAQNDGKGVPSAYRGVRKRKWGKWVSEIREPGTKNRIWLGSFETPEMAATAYDVAAFHFRGREARLNFPELASSLPRPADSSSDSIRMAVHEATLCRTTEGTESAMQVDSSSSSNVAPTMVRLSPREIQAINESTLGSPTTMMHSTYDPMEFANDVEMNAWETYQSDFLWDP
The following text describes a protein:
Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVQRARKARPYTKALDGGWGWMIVFHFFLVNVFVMGMTKTFAIFFVVFQEEFESTSEQTGWIGSIMSSLRFSAGPLVAIMCDITGEKIASILGAFLVTGGYLISSWATNIPFLCVTMGLLPGLGSAFLYYTAAMVTIKYFKKRLALSAAIARSGMGLTFLLAPFTKVLIDVYDWTGALTLLGGITLNLVPSSMLLRPIHIKSENNSDIKNKGSSLSPSSLGAVCTTETSSCDETQEATIRDSALQKAGQPGTSLRVSQNKNKELNHEPNGDSYEKEAISWSCKQKVFDMYLLKNPFFYIFTWSFLLSQLAYFIPTFHLVARARTLGIDTMDASYLISVAGITETVSQIIAGWVADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTIFFAVFAGGYLAMILPVLVDLSGNSRAHQFLGLASFFAGMAVLSGPPIAGWLYDYTQTYTGSFYFSGTCYLLSSVSLFFVPLAERWKNSA
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGRNVLVSSLQNASFSIVFQIICRCITFAINAFIVRNVGREVLGITNVRLLLLESTLLFLSKEAIIRSALSSRHNKQCSWAQLINQLWITVPVCFALTLPCLYIWLNWLSAVDAIYAEQYRFGCFAIAFSCIIEMTAEAPIFVGQVFCFVKLKVILDTGHIFIRSFIFILIVLINKDITIYAFGIAQITSACTIIVGNYAFYYFYIPKLLQYRKDLKKVDDKYVLRDQYGQHFENMDDFPFVSIKQMLPGVLPNPNSMFNSDLQTLVLSFAKQGVLKQVLTEGEKYVMSVSPVLTFSEQATYDVVNNMGSLAARFIFRPIEDSSYFYFTQTIARDSALAEQKREMVQEASDVLAYVMKTVTSIGLLAFVFAQSYSGTVLLLYGGADFVEGGLPEQLLRWHSLAIVLLAPNGITEGYMFATNTSKQIDTYNYYMAFFSVTFLLLSYQLTNWFGPVGFILANCCNMSFRISYSVFYITKHFRSIGMNPLQKSLPGPMYLSVLIVSGIVCKVSEAYFSGRSIVCHLLVGVLCTGLSVGTWSFENRDLLRTGLARYRTRKQSLTPSETHVN
The following text describes a protein:
Function:
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MAVLLVAVLASSLYLQVAADFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPQCKHGECVGPNKCKCHPGFAGKTCNQDLNECGLKPRPCKHRCMNTFGSYKCYCLNGYMLMPDGSCSSALSCSMANCQYGCDVIKGQIRCQCPSPGLQLAPDGRTCVDIDECATGRVSCPRFRQCVNTFGSYICKCHTGFDLMYIGGKYQCHDIDECSLGQHQCSSYARCYNIHGSYKCQCKDGYEGDGLNCVYIPKVMIEPSGPIHMPERNGTILKGDGGYANRIPDAGSTRWPLKTPYIPPPVITNRPTSKPTARPTPNPTPQPTPPPPPPLPTELRTTPLPPTPERPATSPTTVAPATQVVTVDNRIQTDPQKPRGDVFSILIHSCNFDHGLCGWIREKDSDLHWEPTRDPAGGQYLTVSAAKAPGGKAARLVLPLGHLMHSGDLCLSFRHKVTGLHSGALQVFVRKHGTHGSALWGRNGGHGWRQTQITLRGADVKSVIFKGEKRRGHTGEIGLDDVSLKRGRC
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRGKIEIKKIENVSTRQVTFSKRRAGLLKKAHELSVLCDAEVGIIVFSNTGRLYEFSSSSMRGIIDRYDRATEPSTSLIQAEMSQEQAELEHLRNEVTRLRNENSRLMGNNLGGASVQQLHQLEKQLTDGLVLIKEKKDAMLFEEIERSNRKERELAYENDVLRGEMENLKRFIPLTRQPGQLGFVEYTPPAVPTSSAAHSKHDRVSPDTVCYYGSDNTDSETALQLRLPCGDHSRKKEATVLPKRDTNSSSCGSDEMEQ
The following text describes a protein:
Function:
In response to mating-pheromone signaling or nitrogen starvation, it interacts with mat1-Pc. This activates the expression of one of two mating-type-specific genes sxa2 or map3, which leads to inactivation of the P-factor. May also interact with mat1-Mc.
Subcellular Localization:
Nucleus.
Sequence:
MMDERKLSNFQIDGEKAYTGSSQGNSYLEDRQKRQNTFTKRKAGIFKKANELALLTGSEVMVLVVSETGLVHTFSTPKLENVVKSPEGQKLITESLINATTDQNESQASQAKQSSAQLSDSESGYPLDHEEMRISEENGPSHIENLNFFSDIDNFSKTSAEEIASKLFSSVSPTHETLQFDHGLQNLEGFQANEHPEMFADHSIDFYNSNNVDIPALSMLTSQTSSSSTLNLPPEPASREVKIFPKQGKRIFSPSTGIDYETTGQHSVNSPPSTYKHRRSLNKSFATRSEPQTPRKNKIRDSLQSSPLNFPPRDRPPLIPISRIAVPSTIETEERQYRGNQKIINFYAKIFEPNSGLGTSSEGASSSFPDVDPNLAQNGVPYYSLPDIDHNQFDHLRR
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MGKAGKGTGSFGKRNDKSHTLCRRCGRRSFHIQKTTCSSCGYPSKRIRTYQWSQKAIRRKTTGTGRMRHLKTIGRKFKNGFREGTTAAAKTKSATAY
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MASGALQFFAFVLALFGVFGAITATLLPNWKVSADMGSNIITAITQMQGLWMDCTWYSTGMFSCTLKYSILSLPVYIQAARTTMVLSCILSSFGICLATVGMKCTRLGGNRDTKSHTSFAGGVLFILAGIFGLIPTAWYTREIISNFLDPNIPESNKHEPGGAVYIGFISAGLLLAAGAIFGTSCFRKQQRAWIYPNKSQQPFPGAQQENTSGYNLKDYV