lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Constitutively active, ligand-independent G protein-coupled receptor that has immunoevasive and oncogenic activities. Couples with the host inhibitory G protein (Gi) in order to disrupt the host chemokine signaling. As a consequence of its constitutive activity, mediates host CXCR4 inhibition. Enhances degradation of host major histocompatibility complex class I antigens via lysosomes, thereby modulating the antigen presentation to cytotoxic T cells. Targets selectively HLA-A, HLA-Band HLA-E molecules. Targets also newly synthesized MHC-I/peptide complexes en route to the host cell surface. Inhibits the host EIF2AK2/PKR phosphorylation. Displays tranforming activity. Utilizes its C-terminal tail to trigger host MAVS UFMylation via PARK2, resulting in selective MAVS removal from mitochondrial membranes and routing to lysosomes to prevent viral activation of the NLRP3 inflammasome.
Subcellular Localization:
Host cell membrane; Multi-pass membrane protein. Host mitochondrion outer membrane.
Domain:
The extracellular N-terminus and third extracellular loop are involved in host MHC-I down-regulation. The cytoplasmic C-terminus is also required for host MHC-I down-regulation.
Sequence:
MLSTMAPGSTVGTLVANMTSVNATEDACTKSYSAFLSGMTSLLLVLLILLTLAGILFIIFVRKLVHRMDVWLIALLIELLLWVLGKMIQEFSSTGLCLLTQNMMFLGLMCSVWTHLGMALEKTLALFSRTPKRTSHRNVCLYLMGVFCLVLLLIIILLITMGPDANLNRGPNMCREGPTKGMHTAVQGLKAGCYLLAAVLIVLLTVIIIWKLLRTKFGRKPRLICNVTFTGLICAFSWFMLSLPLLFLGEAGSLGFDCTESLVARYYPGPAACLALLLIILYAWSFSHFMDSLKNQVTVTARYFRRVPSQST
The following text describes a protein:
Function:
Transcription factor; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD). Acts as a positive regulator for the cluster gene. Down-regulates the expression of the penicillin gene cluster, two putative polyketide clusters, and one putative nonribosomal peptide cluster.
Subcellular Localization:
Nucleus.
Sequence:
MYPWSSTGTSPFSHPDNEGAESGDMSMGEEQQQPHQRRQKFNNLRACQSCRASKVRCDQPNPGMPCLRCQKSGKPCVDAASQPGKRQRQPINSILEMESRIETILSSAELQDSAGDGETAHSTALRSPSQLSHHIQPFQHLPMGFAIPFNGGNSGTEDLNSSIRSWLNDNITDLDARTTETIFSHYLTNMVPTFPVVVFATGTTAADVRRNNPILFLAILDVASSGFCALETQRKLRKLIVQAYVHCMLRTEQYTLGLLQALIVSATWYRTIEPVEPGEQMDIYQISHTAANMALIMRLGESLNAKSWGGPMFPRREMKKGPGSAFQADSLEARRVWLGCHYICSNTSMSLRAPNIMRWTRLMDECLEVLENSPAALLSDRLLCQHIRLQHITEEFAMHLSAEEASAPAKSRAIQIQVTHRAFKRQLSEWRRTVGDGWDAHCTATSDDVPEDNAQRLTPPPPIVAIEPHAITEFMDTIDNIFRVFTSLDMSTIRALPAMYLIRIIYTFIILVKLYFAAAKLPAQDAVLQVDGLQVSRRFNRVIQMTAGWGPLWPATKLTTVFTKMRSWFESGGDNNCQRLQQAAAWLTGWELKPPSQGRDAHAMNMAEVVSDDGSIVASSSRGPASWVPSLASTDVDTLAFSHEPPLGTEFSIAPPPFRSMSCATKSCSPQAGAAEFMHDEEVPLEGQRLGDLPNIDQMDDVGMDWSQYTNMGFDLYNLDAPFLPNPPSGFDPDAAMKDNCADRNT
The following text describes a protein:
Function:
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.
Sequence:
MISSKMMSSNPEEDPLDTFLQYIEDMGMKAYDGLVIQNASDIARENDRLRNETNLAYLKEKNEKRRRQEEAIKRIGGEVGRGHEGSYVGKHFRMGFMTMPAPQDRLPHPCSSGFSVRSQSLHSVGGTDDDSSCGSRRQPPPKPKRDPSTKLSTSSETVSSTAASKSGKTPERTEASAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHGPRRTSLPRDSSLSQMGSPAGDPEEEEPVYIEMVGNILRDFRKEDDDQSEAVYEEMKYPIFDDLGQDAKCDFDHHSCSSQCATPTVPDLDFAKASVPCPPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPAGASPSTLPSHVPGHAKLEKEQAAALGPASATPALSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSPSVPHSTPRPVSQDGAKMVNAAVNTYGAAPGGSRSRTPTSPLEELTSLFSSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDNKERGHHGASSSREPVKAQEWDGTPGTPVVTSRLGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQSSDLQQSQVPSSLANRD
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MTNYEILKSAVQWISFVFSICFNSILIFLIITQSPKKMGNYRYLMIYFSCFAMFFSTIDVIVAPFIHTHGTSATVLMRRSDSDTIVNLQYVLLILLCSCFGVTITFFAIHFVFRYFALERKGRISYFDGPRLIVWIAVPMFFGIIWGTTVLFFALPTDETTELIRESVMKHYNLEMEDVIYVGASYYRRKSDGTLEMIVSSFIAASIFFTMMGTSFSVVCYYGVLSYRRIANLQNEGESEFTKNLQKQLLKALFLQALIPILLMYLPVGTYMTLPALNLDSEEFSKFVTLLYAIYPAIDPLPLFFVIDNYRIALKGYFLGCPGNQNRVSVAGSDN
The following text describes a protein:
Function:
Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. May be part of the export machinery or may also be a substrate for non-classical export.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVQYAPFLLGKFSDPLLAIMVGCLSYYVYERKMGRPQGHHLHELIKKRWDDRK
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MPRATKYSIAASPQKTPIKVPLNDDRQEKANRRHALNEAQRNSMRSSGTPARRRVSQLAGEDSPHTPSQDQDDMPGVAGSAVTPMKRVLPLLANFEEWMKMATDNKINANNSWNFALIDYFHEMSLLKEGDGVNFQKASCTLDGCVKIYTSRVDSVATDTGKLLSGLAENQGKKRRGDAEDGEDGEDEDGEEGEDGQKKRKKRTARSAEATLATSFSQLQNKKMELEFSVDPLFKKASADFDEGGAKGLLLNHLAIDSKGRIVFDSSDDANDATAEETQATPAPEEREDSRAAEDVEIDISGLAAKYFPDLARLDEQDICPSMKTFDLGDVNGSMDLPFLKAPEDWRNDDKKDDEEEAGNRSGLFLDDDNPMGFDDDDDINMGGFDLPPETGFGEGGEVWAREAIRDPQARVHVMGLGDGEEEEGAEGVEGNMATEGAQYGLSMAHGRDQEQENILSYFDQALKKNWAGPEHWRIRRVKEAGKTAPATKRKEKEPFEIDFSAPLSQSTADMLFTPATSNSTISLPKAQWKSKTKNLLPDDKHFSSRQLLRLFLKPKARMGSRREGRRAQPQTEEPAHGDVDEAYWAHREGENALAEEDGVVEGNYDADFFQDDGLPLPGGSMDDDDDFADARDHFSPVPGEGTEAMQPMDGVVPSSQAEDAFGAQLVTQSRRFRPEYVQYARVAKKVDVKRLKDELWKGIGLEEITAPPPANAPDDPAAKAIDGSLNFTDVVNGLKSVYPEKAMADLSTSFCFICVLHLANEKGLVINNTEGFENLTIRKDFSADLSVAE
The following text describes a protein:
Function:
May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Domain:
Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
Sequence:
MEGVSTAAEKTFVPWVEKMVDVLQSRCEEVGTCTGFLRIINLGTGNGDDSKADRFTVTFPYGGQHLKWEVIFNANYPHLPPDFIFIGEEESFFPEMDNLKHLCNWNANNPAMLFLVVRELVGEYRDHHLRLLAGSRLEFEYNSLISDEALTTTKGSAADDDDDDGGGDDDDDEKGSKMAVEVHVAENEEGQLGPVQFMVRLPVNFKSLPPVFNEENQGEDKVLILVTFQSLEGGNVRTQKCLSPRVEAAFSKLGGLPPISFPHEGCINDYISSITQHVQKMVDQLCESFERRREYISHAVSLLASHIIEFDAITFWRADFLFEEDNGHHTTATTPQHKPQRTPPHKVDLPMKFPSEQPILTFISTCNLHSSLVQPMQKVNRSYPFSPRWSTHEMVTRLRQYVTERLPGVDRDLNALST
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MEEWNSLPNYSSAYHTYAYGMTYPPPPVQNHPSLGWSGTGFTPSGSDGLFLDVPPTAPQNALPQDATRVPGVPLAGSPSDSSSETEPSTPDSWSSPSTDESYALRPPPAPCSPAETACAEPAPCSPAETACAEPAPCSPAEIAWAEPASSSQAEGVGEQGALLEPGPALAAGKRSHRLRMAYSERQVMVLCECYMIKMYLTPAEMKSLADKIGLSYKQVKSWFQNRRMREKRLQKKMTSGGELVLSSVYPSIQAQASKGPSSVYPKISPQTSESLSSVYPDISPQMLTDPTCPYSSIPHQPLESSSSVYPNISPQVLVNPSCCYPSIPPRISESPSSAYPYIPPQVSPSSVFLDESAWLCDFCVWMRESVL
The following text describes a protein:
Function:
Involved in the replication of viral DNA. It is required at the very beginning of the virus amplification, conditions in which a low number of viral DNA molecules enter the host cell, possibly to recruit the limiting amount of initiation factors at the replication origins. Once the infection process is established and the other replication proteins reach optimal concentration, it becomes dispensable. Optimizes the binding of protein p6 at the viral DNA ends, thus favoring the initiation of replication.
Sequence:
MNNYQLTINEVIDIINTNTEINKLVAKKENLFPTDLYDLDKQELIAIILNSDFALSSIKRVLLEVTVEELGTQDNDEDDELEDLDGEIDRVDYIDKDGIRFDVPRETSPHVDKSIVTFNDELLDEANKIAKSIQEHDFNDKAIEEAELKIFKNHLPSIYSMKKENK
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity); This fusion protein includes a component of the F(0) channel (subunit b) and of the F(1) subunit (subunit delta). Two copies of subunit b and one of delta together form the peripheral 'stator' stalk which links F(1) to F(0) (By similarity).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MSTFIGQLFGFAVIVYLVWRFIVPLVGRLMSARQDTVRQQLADAAAAADRLAEASQAHTKALEDAKSEAHRVVEEARTDAERIAEQLEAQADVEAERIKMQGARQVDLIRAQLTRQLRLELGHESVRQARELVRNHVADQAQQSATVDRFLDQLDAMAPATADVDYPLLAKMRSASRRALTSLVDWFGTMAQDLDHQGLTTLAGELVSVARLLDREAVVTRYLTVPAEDATPRIRLIERLVSGKVGAPTLEVLRTAVSKRWSANSDLIDAIEHVSRQALLELAERAGQVDEVEDQLFRFSRILDVQPRLAILLGDCAVPAEGRVRLLRKVLERADSTVNPVVVALLSHTVELLRGQAVEEAVLFLAEVAVARRGEIVAQVGAAAELSDAQRTRLTEVLSRIYGHPVTVQLHIDAALLGGLSIAVGDEVIDGTLSSRLAAAEARLPD
The following text describes a protein:
Function:
Mediates responses to the synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D). Not involved in the response to indole-3-acetic acid (IAA). Interacts with RUB modification-related components and may regulate the cullin-ring ubiquitin E3 ligase complex (CRL) activity.
Domain:
The F/D-rich region (45-62) is necessary but not sufficient for SMAP1 function.
Sequence:
MRPMQLDMLSEMDDAGSSMAMDVDDLEAMEILNEGGLVSDNKLADADFFNKFDDDFDDTDIN
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MIYIVLLALFALPKAVSPAANQNAAEYRALCDLIALKESISTLTEPTADTAVTDIVNDIEMLNISTATDSFIADRDGELKETESGVKKSEKEAWQEKIKKLDQETGEPKTVKYKRLKDKTTRGPANQNINKLLQRAQQLKIAYEQQISEAKSKKTAITTSIKNAIYGKGQEDFQEKALDTNDAKNNCGKAAGSENVGQSLSNDLVCLCIPDQGANGNDLCEHGLQPTAVAVANRGSQTTPQYTTMVNGCKLQHRKRQLTPYLIIQRLAAFDSLLGRQAQTATTAAATRTLGKPHSDGNCDNSATQGMCVNYKQQIETATTGIPWVAQLTQAAHDLTAMNKATEHAAAIKTQLESIQASAWAVYAAAVNTELNQRHPKQNEQPIQATTVNDNKCKPTNATPAECPSDHCVYDDKATDGNKCKPKPGTETTAAAGTGETPKEGAAATGCVAHKDKTTCENDKTGDKQNCAWRRGKDSEPDREKEMCLDSSSLVNKKLDLMAAAFVSLVKF
The following text describes a protein:
Function:
Probably functions as a guanine nucleotide exchange factor.
Sequence:
MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFEDCEGAEDMEKESSALSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTEEERAGASTGRLAPAGATAGFQARALRPRTSAQES
The following text describes a protein:
Function:
Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MEEARSAASQESLDILHDMSKLLNTGLSREQLRACVELIESGVSAEAVAAIVENLRKEAAKH
The following text describes a protein:
Function:
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTELLEKLKKIQLECAKKVIARDDFEKVETIGGMDLTFEKINENPTRAWASLVVVELKTLKPVYQHVVKDIVDFPYIPTFLAFREMPLLLKLYETAKVKPDVYFIDGQGIAHPRGCGIASHFGVETGEVTVGVAKSKLFGYAKEPAPQRGSYTYLKYKGKIIGAVVRTKDNTAPVYVSVGHRISLKTAIDLVLKTSKYRVPEPTRLAHNLLQVVRRKELRR
The following text describes a protein:
Function:
In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, cytoskeleton.
Sequence:
MAELLEAEGTVDWKERCIALESQLMKFRLQASKIRELLAEKMQQLERQVIDSDRQAERAFQQVQVMEEKLKAANIQTSEAETRLYKKCQDLETLLQEKDDIIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLQELELENQNLRLINQNQTEEIRTIQVKLQEVQGKKLSTASTPKPSEGQRLSSLTFGCFLSRAKSPQQVIKSEEVSKISSKELEFPEGNHVEEMDIPDTSLGSQVQEHNKGRRSLQQNSCVLEQNGATKTSYTLQSGDGIKDTSKNSCVTVSDWSSDEEEESKERLKSRCDSTLSSHTSEESTRYSRMGSEMYLTASDDSSSLFEEESFGIKRTEHKKLYSWQQEAQWKAQNSISGKGNCESRSKKGKDGFSDELNKKFQCQRLDYSSSSSEANSPSPILTPALAPKNPSLLPTGHQHPMAFHPSSNLPSAKLRIPNVFSISVALAKRHLSQPQLSSDRMFGRNRNAISMIRPLKPQETDIDLVDGDSMEMVENMDVGYDDGVFSYDTLEVSCLEDSEMCDSAAKKAAGGKPPTPPLHRFPSWESRIYAVAKSGIRMSEVFNTDNIHKNSLLMTSYSTSGLYTSLIYKDMTTPVYTTLKGKATQISNSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRALKRGVSLSSVTSESDYAIPPDAYSTDTEYSEPEQKLPKTCSSSGDNGKNEPLEKSGYLLKMGGKVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSMSSHIIRGDNKQTVQLTTEKRTYYLTADSPNILEEWIKVLQNVLRIQAANPLFLQPDGKPTVKGLLTKVKHGYSKRVWCTLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKEQGPTYLLIGSKHEKDTWLYHLTVAAGSTNANVGSEFEQLVCKLLNIEGEPTSQIWRHPTLCHSKEGISSPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEICCQLIKQTRRRQVQNQPGPLQGWQLLALCVGLFLPQHPFLWLLKLHLKRNADSKTEFGKYAIYCQRCVERAQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQETGMRKPAQSGFALFTDDPSGKDLEHCLQGNIKICDIISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQVRGESEREKLLLMYQTNDQIVNGLFPLNKELAIEMAALLAQVEIGDFERPFSTPAGQVTSQCKANQTLKQVIEKFYPKRYRNGCSEEQLRQLCQRLSTRWMALRGHNAADCVRIYLTVARKWAFFGAKLYLAKPVTPSTLGNTFIWLAVHEDGISILEYNSMRLIVTYVYKSLMTFGGYQDDFMVVINSTHSKDKPTDKFLFTMAKPKILEITLLVASYINNFHQQKAALHHLSAPALLSARKGGAKNKDMGSQPLLLNSRPTKGPTLL
The following text describes a protein:
Function:
Plays a role in L-cysteine detoxification; it has been speculated to be a cysteine desulfhydrase.
Sequence:
MFDSTLNPLWQRYILAVQEEVKPALGCTEPISLALAAAVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGLPIAAALGALGGNANAGLEVLKDATAQAIADAKALLAAGKVSVKIQEPCDEILFSRAKVWNGEKWACVTIVGGHTNIVHIETHDGVVFTQQACVAEGEQESPLTVLSRTTLAEILKFVNEVPFAAIRFILDSAKLNCALSQEGLSGKWGLHIGATLEKQCERGLLAKDLSSSIVIRTSAASDARMGGATLPAMSNSGSGNQGITATMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALCAATTAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHDVEQSIANLCALASHSMQQTDRQIIEIMASKAR
The following text describes a protein:
Function:
Aldolase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system. The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA. The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB. The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone. The cyclization of the last ring could be mediated by the lactamase-like protein vrtG. The proposed post-PKS tailoring steps are a hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF. VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin. Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin.
Sequence:
MTNSPIADLVHHPERVQSPSLVNSKMNGDAKAVTEWTEPGPAAFDFRSDTVTRPTEQMLAAIAATTLQDDDFRQDPTTLGLEAWMAELTGKAAGLFVVSGTMGNQLGVRAHLQSPPHSVLCDARSHLVTHEAGGVASLSGAMVSCVTPVNGRYMTQADLEAHVNRGTLITDCPTRLVVLEIPLGGVILPLDKCRRISEWARAQGIALHLDGARLWEAVAAGAGSLRDYCACFDSVSLCFSKGLGAPIGSVLVGSETLRERARWIRKSIGGGMRQAGVVCAAARVAVEATFLGGLLKRSHARARDIATFWEIHGGRLTYPTETNMVWLDLEAVGWTPERLIRRGAELGLRFMGARLVVHYQIGDEAIGRLQDLMLEILVSGLVDHPRDS
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEGQHKEKNTKIKKSKKPLVVSNRKPFNVFEKKKSAKPLVRDPRFSDFSGSFNANFFRNAYKFLYDSREQEKKIIEKKLKSKNITQEEKDELKKKYNDYKSTDILLKKKEEERKLKAELVKQEKQNILTKNKKPYYYSDRKIKKIVQEKLSSNKSLKKVIKKEKKTLQKERKRNIIPTRRNMD
The following text describes a protein:
Function:
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling (By similarity). Required for normal embryonic development, including normal heart morphogenesis and normal angiogenesis.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with integrins at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides (By similarity).
Domain:
The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain; The PH domain binds phospholipids. Binds preferentially phosphatidylinositol-3,4,5-trisphosphate, and has lower affinity for phosphatidylinositol-4,5-bisphosphate (By similarity); The N-terminal region displays a ubiquitin-type fold and mediates interaction with membranes containing negatively charged phosphatidylinositol phosphate via a surface enriched in positively charged residues.
Sequence:
MALDGIRMPDGCYADGTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSLLRKPRDPKKKKKKLEDAEEETLELEGPLLTPGSGSIYSSPGLYSKTMTPTYDSRDGSPLSPTSAWFGDSPLSEGNPSILAVSQPITSPDILVKMYKPQSLLDKAKINQGWLDSSRSLMEQDVKENEVLLLRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSSDNHMNNSEKEVDEVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEAHGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVADGMNEIWLRCDTEKQYAQWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHMNPDPQIIEPITTDINPECLVSPRYLKKYKNKQPGFVRDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGWV
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
DLFAQLADEVILGIFKLLPRDTLITCAQVCKHWLSLVYDESLWLTVDMSKAKLQHGLLGRILLRGTRVMRIASSRVCSPLLDENLGILPGVAPLSPSMAACNSLFRLTYLDATLCTFEDSTLLTLLLHSRRLRCLSLDSSNLSLSILRAIGDCHDLEVLNLAMCTGITLQGVKALVNGCKRLTHLNLAWTHLSKESIIQVVQNLPLLRQLNLSGSRETMTDEAVLHLISNCIHLTHLDLSDCILITARSLLAIIQETKIEHLALSRCYNIPPQAFSLCVELKSLAKLDVYGLLNGDGVEILKRQLPDTFINSCLFSTIARPVDSKYRGTIWGIRCQR
The following text describes a protein:
Function:
Possible role in sperm motility.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKGEMMDLQHGSLFFSTSKITSGKVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQRDYME
The following text describes a protein:
Function:
Deaminates adenosine-37 to inosine in tRNA-Ala.
Sequence:
MVSCQGTRPCIVNLLTMPSEDKLGEEISTRVINEYSKLKSACRPIIRPSGIREWTILAGVAAINRDGGANKIEILSIATGVKALPDSELQRSEGKILHDCHAEILALRGANTVLLNRIQNYNPSSGDKFIQHNDEIPARFNLKENWELALYISRLPCGDASMSFLNDNCKNDDFIKIEDSDEFQYVDRSVKTILRGRLNFNRRNVVRTKPGRYDSNITLSKSCSDKLLMKQRSSVLNCLNYELFEKPVFLKYIVIPNLEDETKHHLEQSFHTRLPNLDNEIKFLNCLKPFYDDKLDEEDVPGLMCSVKLFMDDFSTEEAILNGVRNGFYTKSSKPLRKHCQSQVSRFAQWELFKKIRPEYEGISYLEFKSRQKKRSQLIIAIKNILSPDGWIPTRTDDVK
The following text describes a protein:
Function:
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MPYANQPTVRITELTDENVKFIIENTDLVNLVAKLHICSASFISLAIDWVQIDANSSVLHDEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAFPAAPDLAPPSRAAQGERVLCAMSGGVDSSVTASLLKEQGYQVIGAMMRFWPDDKRTDTFDSCCSPDAAYEARRVAEQVGVPFYLLDYREPFQRHIVGPFLEEYARGRTPNPCVNCNTKVKFDELVKKAKMLGCRYVATGHYVKRVDNAQGEVEFHRGDDPRKDQTYFLWGTPRDALPYILFPVGELEKPQVREIAAERGLLTAQKPESQNICFVPGKVQDFVAEHLPQAQGYIREIATGEVVGEHLGTQFYTLGQKKGLGLYQSHRVRHVVHLDPDSNTVWVGDYDDCLWTGLKATDANYLLDLAELPTELEVQVRYRTAPVKAHVLHADAEGFELEFAEPQFAVAPGQSAVLYAGSRLLGGGLIADHARELPALT
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
MAEKDSGTNDSVRGYNLIDEAKKTLEAASTRDTVALSRGPKYNLWTGRRDRLVSNINDVNIPGSDSPVSVTLQFFASKGITKQEMVTLFRAHTVGFYKEILAKKGLLQIDQQLALDAGTKGFVLDFASNGDKFQKGFANAIVKMGEIDVLVGNQGEIRKKCSVFNRN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MFFCPFCGTLLLIEPAYPCNRFSCSSCRYVVPIQSRRPLTINHSFLKYNKVVDDDDEKGSSNTVKRGVKEEEEVDGGQVITVRCQNDEKQCDGDRAHYVQIQMRSADEPATTFFKCLKCGFQWKQD