lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MALPLPPGLTPPEIAFLCEMELVTVIPRQRLEGLELLGGRIKPLNPPHRTNVPLWLALLLKRQRRANILPPPWLNSHSLTAILDHEIDHDETFSPPPRLPPQPSANTLPTSPPFLSDNTADAAPDALPYHWLEIGEMLLEAASDDFEDPDNVRKLLRGLREVRMAKLRSGVEVLDAGGGVKMNGVGGMEVGEGRAFVTGVIDGLRKIAASREQQRRDRDREELENGYSGTAADYDDDEMDMQ
The following text describes a protein:
Function:
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
Subcellular Localization:
Cytoplasm.
Sequence:
MIQNKLQNFVDTLPISPEKSCSYYPERLSQIQYFPFPEEISKEVLQFFFDSGFRRNGNILYRTSCCGCKDCLSYRIPLDQFVPSRNRKKLLKKNSDLKICFESPNLTLEKEILYLRYQRSRYQNFVIEESDQELLEGMRWNLFEYKENSLEMTLSLDGKILCFMILDFASDSLSAVYSVYDPDYPDRSLGSFAILSSILYAKELGMKYFHLGYFLPGHPNMDYKKYWTPAQIREPVSNENRWIETDDFQKRYSDFSW
The following text describes a protein:
Function:
Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep binds a specific region at the genome origin of replication. It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).
Subcellular Localization:
Host nucleus.
Domain:
There are 3 rolling circle replication (RCR) motifs. RCR-2 is probably involved in metal coordination. RCR-3 is required for phosphodiester bond cleavage for initiation of RCR (By similarity).
Sequence:
MPSHPKRFQINAKNYFLTYPQCSLSKEESLSQLQALNTPINKKFIKICRELHEDGQPHLHVLIQFEGKYCCQNQRFFDLVSPTRSAHFHPNIQRAKSSSDVKTYIDKDGDTLVWGEFQVDGRSARGGCQTSNDAAAEALNASSKEEALQIIREKIPEKYLFQFHNLNSNLDRIFDKTPEPWLPPFHVSSFTNVPDEMRQWAENYFGKSSAARPERPISIIIEGDSRTGKTMWARSLGPHNYLSGHLDLNSRVYSNKVEYNVIDDVTPQYLKLKHWKELIGAQRDWQTNCKYGKPVQIKGGIPSIVLCNPGEGASYKVFLDKEENTPLKNWTFHNAKFVFLNSPLYQSSTQSS
The following text describes a protein:
Function:
SNARE required for protein transport between the ER and the Golgi complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MNSLYNQALRQFSSIQSDISRIDSEGDVGSSTAFGPVTVSLSSLERTIDEYENLAKKELIQSKQDKALNRVAKFRTDYAELSSQLARLKTKGSLCNGSNVSNGASSSTLRSPTSIGTFAQNANRRVSAIAESPFSLHARNPVSSAPSDPLAAYKMNPSAAAMFGTDTSFSARESHALREHSFIQQTEAQLDVFIAQGREVFGNLVEQRGILKATQRRLRDAANTLGLSRSVIGYIERRSTQDNIIFALGALFTLVCFWYIYKWFG
The following text describes a protein:
Function:
Probably involved in the uptake of galactarate and/or D-glucarate (Probable). May also transport D-glycerate (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MILDTVDEKKKGVHTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLARKLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCYLFVVGDIKRMELQK
The following text describes a protein:
Function:
Has a role in sporulation.
Subcellular Localization:
Cytoplasm. Nucleus. Membrane; Peripheral membrane protein. Note=Membrane-associated.
Sequence:
MMKLFCLNIFRFLYTTSFISAVLSFNQRPINMQEVREPRLFELLAETRDCNIFSELIMQFPDYVHLFQQKDQHITVLVPNDAAFQQCKVKPWAIEYKNGVAVKSTDIVHITEQQAQDNILKFVERHIITSSPIEWNNEYKTIDGTDVHVIKKEEEIYINESIHVLCRKKASNGEMWVLNATLSTPSIRE
The following text describes a protein:
Function:
Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity). Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity). Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatases egg-3, and possibly egg-4 and egg-5 (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the cell membrane of developing oocytes. Plasma membrane localization requires extracellular matrix protein cbd-1. After fertilization, localizes to endosomes in zygotes.
Sequence:
MSSIAQKNRNYFLYIFYGRIFNSSDKTFFIIKKQLVIAPNFFSVDQKLICSSELFCGTACSRSLVVLYENYKKIVILNSPQFFAGLDSGRENQSPDGSVQGNGLKWMLFLCQKSKRTIFSNHSNLFQCPSVAIVLVLALVILGVLAAIPLTLMLTSSAQKMSTDSTDLTDYSIRHPKFWPKTDKIHFDDLGGIPMSSMFPPNVSTCSGFGFACTGAVHMVIPSSKRCDGFKDCQDGSDEENCKECQSVFSCRSHIEEDSKKKRKTKVQPTLICLTAERLCNGVQDCLDGSDEAMCKSTCSKDQFKCNGSNACLPLSAKCDGVKDCSDGSDENNCNKCQKGAHVSLVSRNIKHLFASHVCDGVAQCADRSDEQQCDCKTCSGSDKALCDDGTCIKRSQVCDGKKDCSDGMDEENCPGTCSIEAFATKVKRVTCSDGKDYTESEACSGVEESCGGSCSKCHPKLTFTCPAAGNAQKKCIKRSKVCDGIFDCDDGADEKNCTPVKECGIDNASQFTCDRKCVDASRRCDGVWDCEDKSDEQNCSQCASGSIKCSADKKCLPAYTRCNGVAECSDGSDELKCSCEECLGAHSNTYMCSESNRCLKRDEVCSPYSMCPNATYTDKAYCAALVLKNSGRFPY
The following text describes a protein:
Function:
Component of TORC1 complex, which is an essential cell growth regulator that controls plant development. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy.
Subcellular Localization:
Endosome.
Sequence:
MRAHVVSFAFDGEEVWLNSTSFEFLESINMVVLHPNQVFMILFLVPEVDTTMRSLTVMWDGSLVVAANNKGTCYVWRLLRETQTVTNFEPFTSYMLRMVISSNVSYHPSFVNLSGYTSDLYLAIASSDSTVKIWNVDGFTLEKTLVGHQRWVWNWVFSVDGAYLITASSDTTARLWSLSTGEDIRLYQGHQFMFMPNGTFFGLTKKKPTH
The following text describes a protein:
Function:
Choline-specific phosphodiesterase that hydrolyzes sphingomyelin (SM) releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract. Also has phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity. May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin. Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex (By similarity).
Sequence:
MGHSAVLLSVALVILPACVTGGPVQRQQQHKLLLVSFDGFRWNYDQDVETPNLDSMAQEGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTNKVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRANVDTVMKWFTEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLTDSLNLIITSDHGMTTVNKKASDLVEFHKFPNFTFRDIEFELLDYGPNGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFNSGEHGFDNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPNDGHPGVLQPMLRSGSPLSRQHHLVVVLMGILTGLAKVV
The following text describes a protein:
Function:
Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC. Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination.
Subcellular Localization:
Chromosome. Note=Localizes to chromosomes during meiotic prophase I. During leptotene and zygotene, localizes in foci on chromosomes. Localizes to the central region of the synaptonemal complex at the interface between synapsed chromosomes throughout pachytene. During diplotene, becomes concentrated towards one end of each chromosome. Localizes to the short axes of the bivalents during diakinesis and disappears from chromosomes by the end of diakinesis.
Sequence:
MSFPTLQVRPNEKNPKVLRCHEFLRQSNQLVERNMINTEGRKMLAKLLTKMVSEAKGIYALDERRAELAKSGKLQEKLKSAYQTSLTVMEDRLHIAELSRQVQEKKLTVQQKYYECDDLRKSVQETNTEARRVQEINEQRLVDTTRATEELIVKSASILKNLENSSDVHKLRAMEEEKRILEEVVEGLRDQKKCLADDIRTKKATLKAESKKSFEKTVIECAKHYKLHQSLMPKLDKSKRSLETLKDEEENRRICGSLSLDETMQFDRSFILASMDKTNKPEKAVQQLTSKSSEVSITPQISETAKSSFSKEPIPTQHPMEVGEEPVIEHSAEESVHIEPPNVTEIREVVPQITIQPTRQDSVVQRDAEELDTSAVPSPQPESILDEPEEEEEELSNHENHADQSMDVMEVDQEVPEESPMEVGEQEEIEQPSVFKDILATEQAALSQEQEPEIVEKQADNDVQFVDDQQVGAQLDVEDEEEVMSENGSNKSNNFSFNFFGNSKGTSAGEGGGEGNFDFNFDGIGAGDDGSNNGGSTGDLDFLNYDGEDEGKGSGNTQSDPFGFASNGNAAGGGGDGSFNFNFDGDGEGGATSGAGGNSTSFFNF
The following text describes a protein:
Function:
In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate.
Sequence:
MGNRTKEDELYREMCRVVGKVVLEMRDLGQEPKHIVIAGVLRTALANKRIQRSELEKQAMETVINALVK
The following text describes a protein:
Function:
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Sequence:
MAHHDPIHLIAPRAGLAQLNERSRDIFRQIVESYLATGEPVGSRNISRLIAMPLSPASVRNVMADLEQLGLIYAPHTSAGRLPTELGLRFFVDALMQVGDLNDAERQSIQSQLTSVGQAQSVEAALDQALTRLSGLTRAAAVVLTPKSNARLKHIEFVRLEPEKALVILVGEDGQVENRVLTLPPGVPSSAITEAGNFLNSRIRGRTLAEARLELETALGEARAELDQLTQKVISAGIASWSGGENEDRQLIVRGHANLLEDLHALEDLERVRLLFDDLETKRGVIDLLGRAETAEGVRIFIGSENKLFSLSGSSTIISPYRDAAGHIVGVLGVIGPTRLNYARVIPTVDYAARIVSRLLGG
The following text describes a protein:
Function:
Repressor of photomorphogenesis in the light. Probably part of the COP1/SPA E3 ubiquitin-protein ligase complex.
Subcellular Localization:
Nucleus.
Domain:
The protein kinase domain is predicted to be catalytically inactive. The DWD box is required for interaction with DDB1A (By similarity).
Sequence:
MEGSSNSNSRGFNTSGVSDRNTEFLPVERLTTRSKPSSHVDEYVRSLFGSTSTHKSGEDDSLGIDPFVRSLEWGDVSLRQWLDKPERSVDVFECLHVFRQIVEIVNAAHSQGIVVHNVRPSCFVMSSFNHVSFIESASCSDSGSDSLEDGPISQKEIGSSRREEAVSKAIAIEEKGVYNKLLERKIEKLEEEKTQPFPMKHILAMETSWYTSPEEDFGSSSTCASDVYRLGVLLFELFCPVPSREEKSRTMSSLRHRVLPPQILLKCPKEASFCLWLLHPEPTCRPSMSDLLQSEFITEPRDNLEEREAAIELRDRIEEQESLLEFLLLIQQRKQESAYRLQDTVSLLSSDIEQVVKRQLILKKRGSSLSDFSKDDHQYTSGQPLMSFQANEEPSAFLASRKRVRQGILALENGVEVDEESQGSTLLESSRLMRNFKKLESVYFLTRRRQMKAAASGKSLTRHSPLSSENGRGSMIVSEKSSVSNPVAPKAFFNNDSRQGGWIDPFLEGLCRYLSFSQLRVKADLKQGDLLNSSNLVCALAFDREGELFATAGVNKKIKIFECNSIVNDNRDIHYPVVELAGRSKLSSLCWNSYIKSQIASSNFDGVVQIWDVARSQLVTEMKEHKKRVWSIDISSADPTLLASGSDDGTVKLWSINQGVSIGTIKTKANVCCVQFPSDSGRSLAFGSADHKVYYYDLRNPKIPLCTMIGHSKTVSYVKFVDSSTLVSSSTDNTLKLWDLSMSASGINESPLHSFTGHTNLKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVMSYMFNNTDSMSGLEVDDASQFISSICWRGQSSTLVAANSNGNIKILEMMT
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MDQYYHGSSLYGPLYLYSEGLRYGEMEGTVSGVKISETSHSCFIAAFSSPFFTENHALEKPEWLPYLIALDMSRAGYYLEPLLETSIFYIPTSVNQLPTWFPFLYIYLAIELVVKYRDFPLILRFHVMMGMLLETAFQIVSVASNYMPLIHFKGTLGMYYWAGLALAYIVIIMHSIRCALLGTFSNIPVISESALLHCLFNIGGFQRPF
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Sequence:
MGTVVDAPAVVAEEVTENMLGGKKVTVVFVLGGPGSGKGTQCANIVEHFGFTHLSAGDLLRAEIKSGSENGTMIENMIKEGKIVPSEVTIKLLQQAMIKSENDKFLIDGFPRNEENRAAFENVTKISPAFVLFFDCSEEEMERRLLGRNQGRVDDNIETIKKRFKTFVESSLPVIEHYNSKDKVKKIDAAKPIPEVFEDVKAIFAPYAPKAE
The following text describes a protein:
Function:
Involved in processing of the 5' terminus and the intervening sequences of cytochrome b pre-mRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MSLNQKITKAVALWPKDELRPWLSFPKTLDTSIRARLQKMPPQQANKQLNALNNLLDNVYWNKYIPKQVVLKPQFKPSYYESLTQIRRKEEKAPLWKRLFKRK
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MLFPRIIAASAQRKLSVYLKKGGLVAYPTESCYGLGCLPTLAKALGKLAHLKKRPQHKGMIVIGNQFEQLQPLLQMPSENLQDMLRKEWPAPKTFLLSAKSCVLPELRGKQRSKLAVRVPAHVGARRLCQALQTPLVSTSCNRAGKRACRTEREVRRQFGRDVWIVGGRIGRQKSPSQIIDGETGKRLR
The following text describes a protein:
Function:
Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A. GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (By similarity). Involved in photoreceptor integrity (By similarity). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Golgi apparatus. Cell projection, cilium. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity). Colocalizes with WHRN in the photoreceptor connecting cilium (By similarity). Colocalizes with CEP290 in the photoreceptor connecting cilium (By similarity). Colocalizes with RPGRIP1 in the photoreceptor connecting cilium (By similarity). Colocalizes with RPGR at the primary cilia of epithelial cells (By similarity); [Isoform 6]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.
Domain:
The RCC1 repeat region mediates interactions with RPGRIP1.
Sequence:
MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPDSFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVGNDTGQVGPQADTDGEGLQKEVYRHENNNGVDQLDAKEIEKESDGGHSQKESEAEEIDSEKETKLAEIAGMKDLREREKSTKKMSPFFGNLPDRGMNTESEENKDFVKKRESCKQDVIFDSERESVEKPDSYMEGASESQQGIADGFQQPEAIEFSSGEKEDDEVETDQNIRYGRKLIEQGNEKETKPIISKSMAKYDFKCDRLSEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYMLDDADSSSLEILENSETTPSKDMKKTKKIFLFKRVPSINQKIVKNNNEPLPEIKSIGDQIILKSDNKDADQNHMSQNHQNIPPTNTERRSKSCTIL
The following text describes a protein:
Function:
Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAATAANPEMASDVSSLGAAVSSRNPGAGAQAGGAIVQRANKRRSGLDFDDDGEGNSKFLRCDDDLTSNDKERFARSDDEQSSTDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGTYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVGKLREQLSTSENALTEGTKPWCLSNKDPAAPPENASKGRILDLKTGTVKKEGQQSMRMCMGSRRSFICRMRCGNSSVDPVSVNRLSFMRNRCRNGLGAAKDGEPHYVVVHCTGYIKAWPPAGVSLPDDDPDAGQGSKFCLVAIGRLQVTSSPNCTDMNNVCQPTEFISRHNTEGIFTFIDHRCVATVGYQPQELLGKDIVDFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNREWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQESRPALSNSMQRPQLGQSVNLPLEMGTAQLPSRQQQPPQQTELEVVPGRESLSGYDHSQVPVQPVTAAGPEHSKPLEKAESLFNQERDPRFSEIYSSINADQNKALPASTVPANQPLFTQGNTFTPPRPAENFRSSSMVPPVNIIQQQPSSAGRILAQISRHSSPAQVSGTNWAPGTRPVFTPQQVGSQTVKTRPPSFSMGTFQGTPSSFSPMTAPGSTASPTGAAYPNLASRGTGFTTEAAQTPSTFEPRAAEGVGMWPQWQGQHHGPASGEQHVQQPQPSQPEVFSDMLTMLGDQGPNYNNEEFPELNIFPSFSE
The following text describes a protein:
Function:
Isoform 2 dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms, and enhances phytochrome-mediated photoresponses (By similarity). Can use para-nitrophenylphosphate (pNPP) and phosphorylated casein as substrate at pH 7.5 and 5.0.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Partial isoform 2 (148-485) lacking TPR repeats exhibits enhanced activity at pH 7.5 but not at pH 5.0 with phosphocasein as substrate. This partial protein is in addition inhibited by okadaic acid.
Subcellular Localization:
[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein; [Isoform 2]: Cytoplasm. Nucleus, nucleoplasm. Nucleus speckle. Note=Cytoplasmic in darkness, but translocated to the nucleus upon illumination, when associated with phytochromes into speckles.
Domain:
TPR repeats are required for the binding with phytochromes.
Sequence:
MPGMEAENSNASRAEELKQLANEAFKGHKYSQAIDLYTQAIELNGENAVYYANRAFAHTKLEEYGSAIQDGTRAIEIDPRYSKGYYRRGAAYLAMGKFKDALKDFQQVKKLCPNDPDATKKLKECEKAVMKLKFEEAISVPESQRRSVADSIDYRSVGSGPGSSYVPTKTTAVSAAAALMGVLVVYMGTKAATMVAAAASAALLVVLITFLWGRCSDGFFTKSRTLELEVEPQYAGARIEGDVVTLDFVKKMLDDFKNQKNLHKRYAYQIVLQTREMLRALPSLVDIVVPEGKHFTVCGDVHGQFYDLLNIFELNGLPSEDNPYLFNGDFVDRGSFSLEVILTLFAFKCMCPSAIHLARGNHESKSMNKIYGFEGEVRSKLSEIFVELFAEVFCCLPLAHVINEKVFVVHGGLFSVDGVKLSDIRAIDRFCEPPEEGLMCELLWSDPQPQPGRGPSKRGVGLSFGGDVTKRFLQENNLDLVVRSHEVKDEGYEIEHDGKLITVFSAPNYCDQMGNKGAFIRFEAPDMKPNIVTFSAVPHPDVKPMAYANNFLRMFS
The following text describes a protein:
Function:
Siroheme synthase involved in methionine biosynthesis.
Sequence:
MIVSWSLKDAVVVVVGSGKNAYRRVNLCLSENSSKIFWFCRSSADGGFDVGHLQLDAKKSDAIEILPISEFDPVRSLTTLGKEETDFLVDAVFVSESNHHEKEILHRTCKRYRIPLNIIDNPSLCSFTLPATWSEPPLQISLSTSSNGCRLAQRLLRHVVSSLPSGMPEAIERFGRVRAITKTPEKKQWINHVSDFWPLEKLVRMTEDDLLAIVSDNFSLPLSSSQSSSLANSYESLSTTLDKPSLTLDPEAFPTHKRGSIALIGSGPGSPDLLTVAARKAIMKADYVLADKLVPEAVLQLIPRHTPLFIARKFPGNADKAQDELHQVAFDALSRGDYVVRLKQGDPYIYGRGGEEYLFFTQHGYVPTVIPGISSALMAPISAGIPVTHRGVADQFLVCTGTGQKGSMPKIPSFVPTQTTVFLMALHRLEILVQALIESGWPRVLPVCIAERVSCPDQRFIFSTLEDVVEEYNKYESLPPGLLITGYSCNTLRNTA
The following text describes a protein:
Function:
Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsC subunit anchors the complex to the membrane and contains the site for menaquinol oxidation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNTIWGAELHYAPDYWPLWLIYAGVVVLLMLVGLVIHALLRRMLAPKTAGGEEHRDYLYSLAIRRWHWGNALLFVLLLLSGLFGHFSLGPVALMVQVHTWCGFALLAFWVGFVLINLTTGNGRHYRVNFSGLVTRCIRQTRFYLFGIMKGEAHPFVATEQNKFNPLQQLAYLAIMYALVPLLIITGLLCLYPQVAGLGPVMLVLHMALAIIGLLFICAHLYLCTLGDTPGQIFRSMVDGYHRHRTAPRGDKSAV
The following text describes a protein:
Function:
Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (By similarity). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment.
Subcellular Localization:
Lipid droplet. Endoplasmic reticulum. Nucleus. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.
Domain:
The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid exchange and transfer.
Sequence:
MEYAMKSLSLLYPKSLSRHVSVRTSVVTQQLLSEPSPKAPRARPCRVSTADRSVRKGIMAYSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPPSEQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFYDTYSLSYDLHCCGAKRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKASSLIPTCLKILQ
The following text describes a protein:
Function:
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.
Sequence:
MKFPFHPWRRLLLCALPFAALLTACDDGKKEPPPKPAEVTTYNSVPWDALPATSDADLLAGFNAWRSACARLAKDPVWGEPCASATTVAADPTAVRAFLQERMQVYSLRSSSNGDQGLITGYYEPVYHGSLSQGEKTPVPVYGVPDDLVVVALESVYPELKGKRLRGRLEGRVLKPYDDAATIRDNGSSAPVLAWLGDPMDLQFLQIQGSGRIQLEDGRQLRIGYGDQNGHPYKPVGRWLVEQGLVPKEEISMKRIRDWAEANPQRVSELLASNPSFVFFSLRPDSDEGPRGSLNVPLTDGYSVAIDRKVIPLGSLMWLSTTRPDDGSAVVRPVAAQDTGGAIVGEVRADLFWGTGDAAGELAGHMKQPGRLWLLWPKGAPLPAS
The following text describes a protein:
Function:
Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis. Required for respiratory growth and for normal mitochondrial morphology (By similarity).
Subcellular Localization:
Mitochondrion.
Sequence:
MSAKVVLKDFLSQAPIDKLKATLSGHLPVSCITMDAKITSLQPGYHFLFFSLASPESNLNSDGYESLYSPKPNNPFSFKRRIWLHGVLRFHRPLHLFQTSECHELIQEESVKSPSITKEVEACLPKSSFLTKPTSEKQTKHVYIRRKIYDSQHQLCIEEDRTLAYLNRQELAIPKTLRSKSIPQHSWVFTPTPIMVFRYSALMFNAHMIHWNATYATKSENYPNLVLPGPLLVTSMLEYFRSVYPQMSKNMKRFEFRLLSPAFVNQPLRICISETGNLWIDRFTTDLDPPSLIARGRVYT