lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ensures, when in complex with FPP3/VETH1 and COG2, the correct secondary cell wall (SCW) deposition pattern by recruiting exocyst components to cortical microtubules in xylem cells during secondary cell wall deposition by recruiting EXO70A1.
Subcellular Localization:
Vesicle. Note=Present in vesicle-like small compartments which exhibit microtubule plus-end-directed and end-tracking dynamics.
Sequence:
MMTGTTLILEPVMDSKDELVKQHAKVAEDAVAGWEKAENEVVELKQKLEDAADKNIVLEDRVSHLDGALKECVRQLRQFRDEQEKNIQAAVTESTKELHSANTGLEKRVLELQKEAEAAKSENMMLRREFLTQREDLEIVMIERDLSTQAAETASKQHLDIIKKLAKLEAECRKLRILAKTSSSLSSNQSVDSHSDGGRERVEGSCSDSWASSAFISELDQIKNEKGGNRSLQGTTSSTEIDLMDDFLEMERLVALPTETQAKNSKDGYELSLMEKLEKIQAEKDDLEREVKCCREAEKRLSLEIEAVVGDKMELEDMLKRVEAEKAELKTSFDVLKDKYQESRVCFQEVDTKLEKLQAEKDELDSEVICCKEAEKRFSLELEAVVGDKIEMEDELEKMEAEKAELKISFDVIKDQYQESRVCFQEVEMKLEAMKRELKLANESKTQAESRVTRMEAEVRKERIVSDGLKEKCETFEEELRREIEEKTMIKREKVEPKIKQEDIATAAGKFADCQKTIASLGKQLQSLATLEEFLIDTASIPGSARSVHNKEALLGKDPHECIKTINGRSLEFLAIQNSNNKTSPPCSSSSDSTTVSLIMSSNRGSSEKNRNGFATVFTRSRNSVNLGI
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MKDLGMYASWIYSFLSGFLEKAVHSKLNENICLNIKYKIQMMDAQLRKQKVLSQIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGNHTDPPFVPAPFDLPNKINSMLYLGVSNYFLKSATLAYYRAGVFNITISRDLAAAFNLTTAILKDFVPEIALHCPTACPVLLKLMATSPPVVSLQSDTCRLWITGSVEVFAVLPNSTIQYIFTGNLTTSTRGNLTVIKQKLIISILLKRLQLSLLHSAAGFSQVSLVENFLSYTLRRVVIPVINDKLGKGFPLPNLAHTSLVGPVIKMNQGHLVIFSDVHYKHEQGEDEDLHRHP
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAVNVMSSSPKLKSSETSNHVPSLLANFLLRCCKQKQNCLPMKHTCGICFDLKTNSDMFQTTKCNHFYCLDCIRKYVTFQISNYLVKVKVITCPSPNCFVELKPKQLQHILPKQVTFRWRSLICESSISLKFISYARKLFQNFKLDKSLVKLAKKERWRRCPKCSFYIERSEGCDNMLCRCGCRFCYNCGRKHANGHARTCYSSYF
The following text describes a protein:
Function:
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MYSAPSACTCLCLHFLLLCFQVQVLAAEENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQTELQKPFKYTTVTKRSRRIRPTHPG
The following text describes a protein:
Function:
Plays a role in cell cycle regulation and chromosome integrity. Activates DnaA-dependent chromosomal DNA replication initiation ensuring that the chromosome is replicated at the right time during the cell cycle (By similarity). May regulate replication initiation through phosphorylation of a possible second messenger or metabolite, and by interacting with replication initiation proteins. Has ATPase activity with D-ribose and 2-deoxy-D-ribose in vitro, but not with choline. Involved in DNA damage response (By similarity).
Subcellular Localization:
Cytoplasm. Note=Localizes at mid-cell, forming a patchy ring. Disassembles from the old septum to assemble at the newly formed division site. Colocalizes with FtsZ during the full cell cycle. Colocalizes with DnaA in newborn cells (By similarity).
Sequence:
MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGLAREQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQLSRLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDVRHSNWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTVLSKLYWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR
The following text describes a protein:
Function:
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.
Subcellular Localization:
Host nucleus. Note=The protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.
Sequence:
MFSGGGGPLSPGGKSAARAASGFFAPAGPRGASRGPPPCLRQNFYNPYLAPVGTQQKPTGPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCGGDERDVLRVGSGGFWPRRSRLWGGVDHAPAGFNPTVTVFHVYDILENVEHAYGMRAAQFHARFMDAITPTGTVITLLGLTPEGHRVAVHVYGTRQYFYMNKEEVDRHLQCRAPRDLCERMAAALRESPGASFRGISADHFEAEVVERTDVYYYETRPALFYRVYVRSGRVLSYLCDNFCPAIKKYEGGVDATTRFILDNPGFVTFGWYRLKPGRNNTLAQPAAPMAFGTSSDVEFNCTADNLAIEGGMSDLPAYKLMCFDIECKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLPESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDIYKVPLDGYGRMNGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKKDLSYRDIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTIYDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGGEAPKRPAAAREDEERPEEEGEDEDEREEGGGEREPEGARETAGRHVGYQGARVLDPTSGFHVNPVVVFDFASLYPSIIQAHNLCFSTLSLRADAVAHLEAGKDYLEIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRIPQSSPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREYVHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLTAVGDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRKNNCAFINRTSRALVDLLFYDDTVSGAAAALAERPAEEWLARPLPEGLQAFGAVLVDAHRRITDPERDIQDFVLTAELSRHPRAYTNKRLAHLTVYYKLMARRAQVPSIKDRIPYVIVAQTREVEETVARLAALRELDAAAPGDEPAPPAALPSPAKRPRETPSPADPPGGASKPRKLLVSELAEDPAYAIAHGVALNTDYYFSHLLGAACVTFKALFGNNAKITESLLKRFIPEVWHPPDDVAARLRTAGFGAVGAGATAEETRRMLHRAFDTLA
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MSQVAGNPHVPRKYILEKPQLVETFHSSPSFAKIVSYVQCCAEAVEEMSRSAWLQQRREEKHPTIVFFTDVFFPHLRSIVASIPLEDMKQQRFGNRSFRVFHSRLEENIFDLMRGLVATLNRGLGDTTERQNRDISAGEVLKEARANENGDDPLVLELAEYMKDAFGNSVRIDYGTGHELHFFIVMLICMQECGDNGAPLQSDVPVVVPHKVQRPPPPPVEQRDALLQLRRAMVFDVFSAYLSFMRHLQHHYKLEPAGSHGVWGLDDYHHLPFVFGASQLINKEVPTATPETTTNANNNAENGSENSNGNANHELILPKHVCEADIVRRHAEEYLYFAQVLWVIENKSGPFFEHSSMLYNISGVDSWKKTYTGMVKMYAAEVLLKFNVVQHLLFGEHLPWPEQQ
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (By similarity). Acts as a scavenger of H(2)O(2).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDAPRRSSRLAAKIANVLDSKGTIIPEAAPVMLKKPAKDESVDSTIQVGDVIPDITLPDEDGTSIRLRDITANKGLVIFAYPKASTPGCTKQGCGFRDNYPKIQASDYEVLGLSFDTSKAQKAFKDKQNFPYHLLSDPKGELIKKLGAEKPGGGKLFRSHWIFEKGTGKCIVKEIDISPLVSVDKAFAVITDSEP
The following text describes a protein:
Function:
Part of the Zra signaling pathway, an envelope stress response (ESR) system composed of the periplasmic accessory protein ZraP, the histidine kinase ZraS and the transcriptional regulator ZraR. The ZraPSR system contributes to antibiotic resistance and is important for membrane integrity in the presence of membrane-targeting biocides (By similarity). ZraR is a member of the two-component regulatory system ZraS/ZraR. When activated by ZraS, acts in conjunction with sigma-54 to regulate the expression of zraP in the presence of high Zn(2+) or Pb(2+) concentrations (By similarity). Also positively autoregulates the expression of the zraSR operon (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MIRGKIDILVVDDDVSHCTILQALLRGWGYNVALAYSGHDALAQVREKVFDLVLCDVRMAEMDGIATLKEIKALNPAIPILIMTAFSSVETAVEALKAGALDYLIKPLDFDRLQETLEKALAHTRETGAELPSASAAQFGMIGSSPAMQHLLNEIAMVAPSDATVLIHGDSGTGKELVARALHACSARSDRPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLDEIGDISPLMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAEEVSAGRFRQDLYYRLNVVAIEMPSLRQRREDIPLLADHFLRRFAERNRKVVKGFTPQAMDLLIHYDWPGNIRELENAIERAVVLLTGEYISERELPLAIAATPIKTEYSGEIQPLVDVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MNGSPYSSSSWVKSSLSTNSLGSLSNSYAAGSAGGSGNRSTVRGDSNKDQKLLGYLQKQSKSQLPNSNVKIFKKKWFWFESDSGTLFYSATSTGALSTPLTPSSLSENIKSIKITSQTTIEQSISFRLELIIKDKVPNDEFTVLNWVNTLNQWKKLNCNLDFTNDTTTTTNNSNNSNSNNNNKQYNSIENPDYLGKFGEVEGLLNAMSVSTSLNTMKTVKPLINKIQNDSEQLKLVLSQVEQQIEFLKSCQLELISHLSNDNNNNNNNNNNNNNILQILQQQQPISSKRTVSNDNLVGSNNSNNQLSLSIGLPINLNTSNTTTTTITNNTIEGENDDDEEEDEINQTSDIFSLLPTHLTLYVFSYLEPKELLILAQVSSQWQKLAGDNLLWVRFVTHFITPASIFDKSHNWKSVYLANTVTSLGYCSNYYYLKNQQKGGICTNKEKYMNRAISMYGVTPLTSLSSSKEGWLYKRGDDLLRIWKKRYFVLRDSSLFYFKHQNDNFPCGVILLNHGTKLKRASASTRKNCFKILQSKNSTITMVHKKRMPYYLSTDKEDDCNDWMILLNSIIKSNTQHQNNYGVITISGTSNNNNNNVYINNNNNNNNNNNNNNNNNNNNNNNNGSQSYNLPPLLSKSPSFSNALTSSTGISGGGGGSTKSRKSHKKSFSSGGGGSGGNNNFEQMQQQIQSVHLTPIYPMFGVALSKILENQSLITTQTHLKIPFILYICLNYIISKGIKEEGIFRVSGSLREVQELQEHFEQGREIDLDQHDIHAICGLVKTFFRKLPHTLVAADLDEYSTSVQLAASQTEDEKIQEFKFIFESISENSFHIFELLLYCLRLIVRNESFNKMTIENLLIVIMPTLKCSPVLITNGIKYYDEIFIKK
The following text describes a protein:
Function:
Involved in the export of mRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFPTDMETNEILDQLDKIDERNEDILLKSLKASKCTYKPWSREEFLRRLLTYRSRWAYVNDPQIGEINCCLNGWLCESNNILVCDVCRNKINLTALQQVDAENDSLNELPEKTKERLEVSLKEEHQDNCLWRLHKFPPDIYHLSVSAELVQVGRRFNSLSTRLVSTHLPEEMTLKRLEKVANKIRVDWEKEDAAVLLGIALTGWSEQVPGRLYVCNYCHRRLGVWNLQSEGQDFDVLEEHKKSCPWVIPQPFTDLLGWQQIFELLCKESIFQSTTKTMDVSQYTDYTFSLLQGLR
The following text describes a protein:
Function:
Anion/proton exchange transporter involved in iron and copper cation homeostasis. Involved in intracellular iron metabolism during growth on fermentable and non fermentable carbon sources. Required for proper copper-loading and maturation of multicopper oxidase FET3. Important for adjusting intracellular compartment pH to more alkaline pH under iron limitation. May also transport chloride ions through the plasma membrane.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein.
Sequence:
MPTTYVPINQPIGDGEDVIDTNRFTNIPETQNFDQFVTIDKIAEENRPLSVDSDREFLNSKYRHYREVIWDRAKTFITLSSTAIVIGCIAGFLQVFTETLVNWKTGHCQRNWLLNKSFCCNGVVNEVTSTSNLLLKRQEFECEAQGLWIAWKGHVSPFIIFMLLSVLFALISTLLVKYVAPMATGSGISEIKVWVSGFEYNKEFLGFLTLVIKSVALPLAISSGLSVGKEGPSVHYATCCGYLLTKWLLRDTLTYSSQYEYITAASGAGVAVAFGAPIGGVLFGLEEIASANRFNSSTLWKSYYVALVAITTLKYIDPFRNGRVILFNVTYDRDWKVQEIPIFIALGIFGGLYGKYISKWNINFIHFRKMYLSSWPVQEVLFLATLTALISYFNEFLKLDMTESMGILFHECVKNDNTSTFSHRLCQLDENTHAFEFLKIFTSLCFATVIRALLVVVSYGARVPAGIFVPSMAVGATFGRAVSLLVERFISGPSVITPGAYAFLGAAATLSGITNLTLTVVVIMFELTGAFMYIIPLMIVVAITRIILSTSGISGGIADQMIMVNGFPYLEDEQDEEEEETLEKYTAEQLMSSKLITINETIYLSELESLLYDSASEYSVHGFPITKDEDKFEKEKRCIGYVLKRHLASKIMMQSVNSTKAQTTLVYFNKSNEELGHRENCIGFKDIMNESPISVKKAVPVTLLFRMFKELGCKTIIVEESGILKGLVTAKDILRFKRIKYREVHGAKFTYNEALDRRCWSVIHFIIKRFTTNRNGNVI
The following text describes a protein:
Function:
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes around the centrosome.
Sequence:
MSAFCLGLAGRASAPAEPDSACCMELPAGAGDAVRSPATAAALVSFPGGPGELELALEEELALLAAGERSSEPGEHPQAEPESPVEGHGPPLPPPPTQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELETDVKQLQDELERQQLHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALKEDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQGKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNDLKRLIQSIVDGVEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKEQSRPAAAAFPRGHGVGRGQEPSTADGKRLFSFFRKI
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNQLNSIQSSLDTQRKRNKSLKQEKSYYEQAKRRKSVFVDQIDSHSSNQIIKNYKSFLPQIKKNQVNSDGQDVSIILNHFKLYQQQNVKPNNWNQFFASIWDFIQKNGDIYDLYQELFKKLLFLQFQQLQKQILDLCYQEKILITLGYELQQDQLFNQLFSQFVQNYQLCLQELFSKGKFNKKQLQDVQSLIQMNNIIEYVNIDVQSEKFQQGNSTIWMINRKCNQTQQYKLNLKIIRRYFALWLHEARNLEIIKVLPRQLLTASHPFINAKLSQPILIVDLDETLVHFDQASNRLMIRNGSQQFLQQMHKYYYVIIWTASLPRYAKWALKKIDQQIHQYIDVLLTREYCIPHEKGFYQKILSMLGQELSLLLIIENDYRSVIDSEKDHLHLIDSYLGQDDNVLFDLSNRLIDAYKFYQDGFSLQRAFKMTSIKQN
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLGDRKTQTTRLLIAILVLLTALPQWVVPAAHMGLLKATWQPLCALTKELDEVPGEALQEVMAILSKASELEKEAMMLKIYSALTESESEAKKATTVAAHMRRLAHSQRQYFMTIDAQKFLAASKASAYAKGRLDEFLQVAGSMKDSSNRGCLLAGSNQNGLKLTDGALDGVQCKNSASQVAATTRATKTITAAGISGPIHGQESSNRIQHSANECRLFGKTHANGLGHTAALENPKLVWAGGYITIDTSSGDDGKVTLTQLTPAGTQTRPEAKPWQDCIEAVGAMPTAGSPAYTNDTAVLATSESAADLFGRVQKNIEDGTLSNTKTEITAMFGDQPEVQVNKLLSNAANYQLKEKIGGKNKGTKLNEIGTAAELEAVLAAVDIKLIETRSKLIKQLNEEKQKKGGDDTTKTSETDETCQAKGTGDKCTSPCKEVEEGGKKKCTLDKEAKQTAEGAAKQEGKDGKTVDCSKLYTQEKCEKANEGQATKVCGWKGENTDGSDKSGYKCRNGSFLVKKQFALSVVSAAFVGFIEFKSSKDNTNFRLIF
The following text describes a protein:
Function:
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways.
Sequence:
MAELGAGSLLTGDPAFNYQEHELNERLKRLYPAVNEEETPLPRSWSPKDKYSYIGLSQNNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGVAFTDLPPNLYPTVGLQTPGEIVDANFGQQPFVFDIEDYMSEWRAKIHSMIARFPIGERLGDWQAVLQNMVSSYLVHHGYCATAMAFARATETMIQEDQTSIKNRQRIQKLVLAGRVGEAIDATQQLYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRCFSVRSPKSQDSYPGSPNMSPRHGATNPHLHSTGADSPTCSNGVTPPNKNKSHNKYTGISSASSSPSSSPSSVNYSESNSTDSTKSQPHSATSNQETSDSEMEIEAEHYSNGVTESSTRIMNGTYKHQEILQADDNSVDDTCSSRQLCGGNQAATERMIQFGRELQTLSEQLCRQYGKNATHKKMLQDAFSLLAYSDPWNCPVGQQLDPMQREAICSALNSAILESQNLPKQPPLMLALGQATECVQLMARVRSGSCSFARVDNFLH
The following text describes a protein:
Function:
Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Interaction with the prion form [het-s] of incompatible cells triggers a lethal reaction that prevents the formation of viable heterokaryons.
Miscellaneous:
MISCELLANEOUS: In P.anserina, the het-s locus exists as 2 incompatible alleles, het-s and het-S. Strains of het-s genotype (e.g. A, C, s, and V) can display 2 distinct phenoypes, the neutral (prion-free) [Het-s*], which is compatible with het-S strains (e.g. D, S, U, and X), and the reactive [Het-s] phenotype, which causes rapid cell death in het-S strains. Although the two alleles het-s and het-S differ from each other by 14 amino acids, vegetative incompatibility between s and S strains can be attributed to a single amino acid difference in the proteins encoded by the het-s locus. A sequence for the het-s allele can be found in strain s (AC Q03689).
Subcellular Localization:
Cytoplasm.
Domain:
The globular domain exerts a prion-inhibitory effect (in cis) on its own C-terminal prion domain. The het-S globular domain, but not the het-s globular domain, is essential for programmed cell death; The protein contains a prion domain (PrD), but beta-structuring in this domain due to incorporation into a het-s fibril induces a change in its globular domain, generating a molecular species that is incompetent for fibril growth.
Sequence:
MSEPFEIVAGALGVAGLFNNCVACFEYVQLGRHFGRDYERCQLRLDIAKVRLSRWGEAVQINDDPRFHSSAPIDKSVQLAKSIVEEILLLFESAQKTSKRYELVADQQDLVVFEDKDMKPIGRALHRRLKDLVSRRQKQTSLAKKTAWALYDGKSLEKIVDQVAGFVDELEKAFPIEAVCHKLAENEIEEVEDEASLTILKDAAGGIDAAMSDAAAQKIDAIVGRNSAKDIRTEKRARVQLGNVVTAAALHGEIRISDQTTNSVETVVGKGESKVLIGNEYGGKGFWDN
The following text describes a protein:
Function:
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
Subcellular Localization:
Nucleus.
Sequence:
MAAPEPKRRKHSHNEDSEEFPVKFPDVIIFIVNARIQKVRLKKLRHLGRSKGFVISSELNESVTHVVTELNSRDHVISVLQRICKSQRNTELNAFEFAQKAELLSLKWYTSCMEEDKPVEITDEHRVSSRKPLDPDALEEDGEDKPKNRRFACQRITPLNHPNQKFTEALEFLEKAAELRMGDNSRSRALAFRKASAALKALPEEIKKPEDVENLYDIRGGAHCKGVILDILENGYSAEVEGIKRSDWYQNMSLFTGIYGCGISTSAKWCQMGLRSLDDVKGSYILNLTRSQLKGIEYYNDLNTPVTKEEAKWIHDAVSQEVAAIQPGSTVVMTGGFLRGKDMGHDVDFLISHPEEGKEKGILGTLLQALTKKGLLDYTDIQNSTVTKTTVQTGMDASRNTMDHYERCFSIFRLPKTAQSHRSDESSERTVAEDSAAMDVVPPASESSPSMDVTPANGTAIPGLSLLEKTNGSTTSPSEIVQKTEDSGRSWVARRVDFVIAPAGQYAFALLGWTGSKMFNRSMRDYTNKVMNMNLSSHGLFDKTNNCSLQAKTEEEIFELLKLDYKPPEERNC
The following text describes a protein:
Function:
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MSKNSVIIVAAGKGKRMNSSISKQFLQIKNKPILYYTLSKFSTHESIDEIVLVTLEDKIEVCSDIIDKYNINKVSKIVPGGKERQDSVYNGLKGVSKDCEVVLIHDAARPFVTSDIIENGIRYTNQYGAAACGVIPKDTIKIKNEKGFAIDTPNREDLFIVQTPQCFNYNIILSCHEKLKKHNKKVTDDTMVLENYGKSVYLYEGSYSNIKITTPEDLILGEQILEKLT
The following text describes a protein:
Function:
May functionally interact with Polycomb group (PcG) and trithorax group (trxG) proteins to repress transcription (Probable). Required for Egfr pathway function and MAPK activity in CNS midline and tracheal placodes and for CNS axon development and tracheal tubule development. Required to establish the primary axon scaffold in the brain and for lateral positioning of longitudinal glia, longitudinal axons and neurons. Required for glial survival. Required to establish the proximo-distal axis of the developing leg and for wing vein and alula development. Required for regenerative growth in leg imaginal disks. Required for the initiation of anterior migration of border cells of the ovary.
Subcellular Localization:
Nucleus.
Sequence:
MPPHILGSASGSSSTAAASPPTSSASQTPPSPAIHHSHLSQHNATSAMSKPTTPQRHGNPSLLPTLQWPWNTSLGSTSTAVPAASANKNKRTAAGSGAALGLSGEGSCLTGGGAASAKKARSDLPGSFDASKRLKVAAMEESQTKITGFFKSQMKPSPGGGKLSPQPGQQSNPANTLTMSTPATTASLNKYFNILSQLKEQKAQQQQQQQQASKTLPTPAPVAPVPSAPPVAPVVVTPSPSLPVPALKKIERSNKQPAKIAQVAPNLRKTPSSGSSGSSSSSSSSSSNGSNTGKSPTKKHVAIAPRTPEMKQQQQQGKAAMVYRPPVTSTALKQKQISPPAPVAAHTPAPAPALNPTPAPANPTLYQLPVQLPNLVQLPPQLAAAANIMQLNNVAKAAVAAAATNNAAAQAAQAAQAAAAQYFLNGTVFKLQQVTTATTTTATTATAAAAPAGNPFGLLNLATAGNPFGLPNANGQFPIEAIPGAGSYLHHQLLLARQNNMSLNETMASNSCGNMNFVNPLNNQQVGLKDNKLYIVNSAEYLGYLMSLQIALNNQQHQQQQIISATQPPPLAATNNNSTNTATQPPPLAATNNTNSNTANNSTASNSINHNASNNLSNINNTAIQPQRAIVKPPLHSSTQPPPLVTISSMPACSPAAASSPAAKRSLPAAKPYQKRLTAKGRVGTAPIIATPTTPPPLVPTSATKELGQLRKSTGTTGTPTGTPTPTPPLVSIAPSKLTPTLSVSKQGPTMKLANSAPDLFDLVKNSKLVAKVSQPLTPLPFSSPSSSSNGSHGSHGMRSSPALSTSNSCTLSAFSKIKVETTELASQTGSLTSSSIPTISLKPQSFAGQLPKREPESETDTLKHDLLPDCTNSNSNSNSCSSSTYSHSVSSAADLSLEASTPAPSPSPSASPSGLGSPSPAASNLSASSRRAASQTDMLSELVTSSCISSGGDDCSQATDSPPMPALPLAKSEDATTPISTVSGGSSSGSSNYDEEDDKSVASLETHQTHKRLRDLPTPESGIGGSLSNSESSNSIADAISSKSASVGPPTTAASSASSSASDSNSLASNAPSPASPEDCSAAPSPACSASTTGSIPPSTVVDIAMVEATSKSLPKSAISPILSQPKTIRFPAGAGASGKGGKRHDGVCYWDKCNKKHESNSKLLDHMQTHHVNTQTGPFACLWVGCKVYNKESCSRRWLERHVLSHGGSKQFKCIVEGCGLRFGSQLALQKHVNNHFNATDNARESTSKRTSDPPVPKQLRKNGKKLRYRRQPFSARMFDFFDTGIMEGLQHRLRQISTLTNGAQAIEFQGQCMMRRRNSQGGYECFVRWSPREIISDEWLPECLNRTRQHTKVLHIKQMRPAEKTRVDSLLSTAFRLRYDSHLFADDYNVNEQQVGEASGSDCDEDGDGDQEEEDLEDQDEDEEEDGSSSSRSASCETVSSYQQVLSIAKLQMQQRRKHPRKPPKVTPPAREKLVPTDALVPI
The following text describes a protein:
Function:
Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA. Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases. Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis (By similarity). Repairs monoalkylated bases, specifically N1-methyladenine and N3-methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2-ethenoguanine (By similarity). Acts as a gatekeeper of genomic integrity under alkylation stress. Efficiently repairs alkylated lesions in ribosomal DNA (rDNA). These lesions can cause ss- and dsDNA strand breaks that severely impair rDNA transcription (By similarity). In a response mechanism to DNA damage, associates with PCNA at replication forks to repair alkylated adducts prior to replication (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Relocates to the replication foci during S-phase.
Domain:
The PCNA-binding motif (AlkB homolog 2 PCNA-interacting motif, APIM), mediates the colocalization of ALKBH2 with PCNA at the replication foci, coordinating the repair of alkylated DNA damage with DNA replication.
Sequence:
MDKFLVRPDLRDLQGGGEEPAPTGGASGDLKSPDWRHLRAEGLSCDYTVLFGKAEADKIFRELEQEVEYFTGALAKVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLTPKPWVPVLERVRDRVCEVTGQTFNFVLVNRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFIFRHKDSRGKRPRRTVEVVRLQLAHGSLLMMNPPTNTHWYHSLPIRKRVLAPRVNLTFRKILPTKK
The following text describes a protein:
Function:
May be an antiapoptotic factor.
Sequence:
METTTTTTTAAATKGTNDAMETSSSTTATPTTATVVPQVVRNDEYINTFYDIANKLDTNPSFPDDDKLFSKIIELSSKTKQTKKLSPQFISKYFKRFPTLQEKAIDCLIDLFDSSDEDVIMRVNALKAIPTICRDNPDHIAKLVDILSQLLNTDSKVEAEHTKNSLIELYKLNSVTTLNSFLTFLESEESSMEDQPASSTLLSFLKESIIPLVRTEYSKSSIETQTFFRVRILKLIAKCTSTTELDLLFQLLECFTQYKVQETITDLETNVLPVIESQSLDTIRKKLINFTKILLFKSKKPHTEINSNKLFDLYLNKIFPKVNELDETNKTELVSVFSQVTPHMTQEISMQFLEPVYNLFKATVPSKTTTPVADVDLQFTIVEALLFALSSIGSKSTSSLCKLCGFKLVTGQPSDMNADPVKYEDFLGRHRFLDEKCRETLGKAKKAIPNLGNPKDKAQLKLAQKTLLSTQNILTIMQNLLKSPPVTNINNLVISSTIFKGKQNLIHNVSPVFKPQQHQHQHQQQQVQQKQYQKYQAQQQQQQNIPIQRNQQQQQQQKSNRYQPYVTPGRRHQDLDKPKQDGVEVHYYSEKHNKPSSFKGRGPKSY