lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Subcellular Localization:
Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein.
Sequence:
MSRTTKETFRQRMQGFFGMRGPRGSNPGDGQFKKGEFFITPTLKKDLSRESPLNVRMKAINHLSALVGEKKLEDNGIEAIWVLISDLLDPQVNTDHRHLVLHFLKCIIIGQSEFLGPMRYHFFQVVKGHNIFEDLPQRLDMLRALSDNGKNLLDFEEEMGPFLMLWMPDVISYGKTAGFLQVLVNVIKYNSCYLDDHIIAGLVQHTCSICSRTEKERDIEQAIHVLDAVICYSCLPSESLYHFITALCRTVSVKRFCQSSWKLMRNLLGTHLGHSAIYTMCCIMEDSHNISDVVLLRGAVFFVGMARWGSMKVQSLRHINFTSVLPSFERALTCKHVLVAYEVTLSLQRLVKKNGQDIQAVTWDIILGIIEKLFRNIEEYAVSHEYLPTQLHDLLTMIERLYEKNSFNGSQQQLFAIVEEFARLRPDSSVLCLIRYRAQAIHPTKENWIPNLQKLLDRYFRSESRTVIREAALNVLSSTLHSSGSLYEDDLIKMVALPQLKSICDDRDPVVRKCAVKLLMDSAKVCQSPFCLDILDIIEKVVMKTMHVRSHVGGGGGVESHHTPPHSEEERDLVDVMTAVTGLLELFKVKMYRVPSSHAVFAFELLGTHMKQQYEHKYNSDMASNIRAKVFEFLLQLRADSMCRLGFPGERGIYKYSPYILCDSRLEMELAGKTSPPVCSSPPPGERHLKPTIIPFIQAFKMITTCLREETHWKVLSMVLPCLTKALQNKNLVLAANANMENLCVVLCSMVEDRSHMSRLQRSEGFNRIDFYTGIYSALTALVPYHTLLDQQKKVYLIKCFEAGLKLKCAQQCVDGLTLCVIEMQETMLKVLPSIILVMSQMSATATMAIPVLEFLSSLIWFPKLYANFVESEYMSIFAVALHYTNPFKFSLYVVSLAHHVIAMWFIKCRLPFRREFVNCITRGLQANALRPVPDFDGSSSPPIMKLRRSSSLTDRTKMNEKGKGKGEDGSSSKALTTEEALDMLNRLLTQTCLDMMARYTYSTLATYPKRSPVSEFLLAGGQSQSWLVGNKVVTVTTSGGSTRLQRNGVCERCNSLIQQYVETTSTASQEKVEGETESWMSKINEEKADQEAKQPSSPSGTGFGRLKRQRSKSGNTQRIDSSGNALQKKVTRTEDQEEVKHLTLFSSVTPEVTSSGLDTSRGSSAESLKGSDGSSSHHSKKEDGSHSARAGSKVMFAGDKFQGSKVNQSAAAAGTGSNKPTPKVMFSGVSDVSQGSKAASSASETSHGPSSEGWKASESQSGMSHSKKGESSHSSKAASKVMFALDTGHSSKTNQKEASTLASGSIKPTSKVQGGSDTNQGSKVNPTETGNGMAESGDQLTYKPRYSSRVSSASIYQCNCWCQGWAEIHVRRPTGNTSWIMRIQNGGALLPSSHEFPLADISALLLRNRDLDIDADMVIPDDSGSEDETCSLEEEEEEEEEEEDMHDGKQSISHRALLDFSSPSFHDDDDLFSDILCLESDMDSLSFPRTEMGLSPMGPSFLQDYATMRKRELGEKRESAYCEVIKDLHEATDTLDKVGTSPKPGLLRSNSSPALISMGEPSNLPTLSPRSVARSFLEDAAQKPGSYKDPSFLSKRYAQDVPSELWSSPGIEKTDIGGDQEDGLLQTSGSSEFVDISYKDIENEESKATAKPASSTAPGDSTTDAVDVSAAISKTTKDQVEEHEPKAEKPKTLPVVPHLSEEESIQQSRKLLNYSSSRPRGHTVSIMVHRDRPKGQQGDSRSRRTSEAKHRGSFTQKDSYRSGINPSFVFLQVYFSPLFTEGAERPIAIPLSQVGQRAVKVLDRIPPYDTHKIGVVYVGESQANDETEILSNVYGSARYMNFLRGLGQLVSLKDIDPDEVYTGGLDRTGSDGNFTYCWQDDIMQVIFHIATLMPNKDSDPMCNGKKLHIGNDFVSIIYNESGQPYKLGTIKGQFNFAEIIVEPLDNDSNLVSIQAKPELEQMLGRRGPWMVSDQRAALLIRQMALHANLASQIHRSRPAEAYCSNWLERLRHIIRIQDKVRHMGAPSNPMMNVMSSRYLQTPEKKSSGHTKAAKISDFTDYA
The following text describes a protein:
Function:
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVFYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGRDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTADERKLFDHLKSPHLKYWVPFIWFGNLAAKARKEGRIRDSVDLQSLMTEMNKYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTVEMG
The following text describes a protein:
Function:
Component of the phenyllactate dehydratase complex FldABC that is involved in the fermentation of L-phenylalanine via a Stickland reaction. This complex catalyzes the reversible syn-dehydration of (R)-phenyllactate to (E)-cinnamate in two steps, a CoA-transfer from cinnamoyl-CoA to phenyllactate, catalyzed by FldA, followed by the dehydration of phenyllactyl-CoA to cinnamoyl-CoA, catalyzed by FldB and FldC. In vitro, FldA can use 3-phenylpropanoate as a better CoA-acceptor than phenyllactate.
Sequence:
MENNTNMFSGVKVIELANFIAAPAAGRFFADGGAEVIKIESPAGDPLRYTAPSEGRPLSQEENTTYDLENANKKAIVLNLKSEKGKKILHEMLAEADILLTNWRTKALVKQGLDYETLKEKYPKLVFAQITGYGEKGPDKDLPGFDYTAFFARGGVSGTLYEKGTVPPNVVPGLGDHQAGMFLAAGMAGALYKAKTTGQGDKVTVSLMHSAMYGLGIMIQAAQYKDHGLVYPINRNETPNPFIVSYKSKDDYFVQVCMPPYDVFYDRFMTALGREDLVGDERYNKIENLKDGRAKEVYSIIEQQMVTKTKDEWDNIFRDADIPFAIAQTWEDLLEDEQAWANDYLYKMKYPTGNERALVRLPVFFKEAGLPEYNQSPQIAENTVEVLKEMGYTEQEIEELEKDKDIMVRKEK
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MSTDCVRWSLRPPERQVDDDIAQLVAARDSLHASLGKSREVSYLLHERLQNFQERLSLIRRNAAPANEESKSTMELSRRIDKASQSITSIRKLYNVFHDLRTIIMGDLSLDLNGYLAGVMQLEEALDYYRHEFAAAISCLQEAVNFLETTSTHSLRLRNILRNLQAEQAGDKFNGDLLIVAQKKLENEFSRLLAENCLPVSLPTQMGPQTEDAPFSSTELEYLFGFPSEALQKLQVIITRLAGTEHYSRCLKEYQERRSAQCRQSLEALEVEYSRISASELIDKVTWIDLQNIIKKWTQQLEVVVKVLYAGERRLARQVFKDMGQPVWVECLNYVAQPGMSAFFQFGESFSTTSRSPEKLCNLLEMLEGMEKSEHSVIQVFDGQACCGIRKRYRELLKQVTYGAFKAFWDMSEWVEEQKEPQIHDGGVMRLCSFVVNYLDYLVRDYLEPMSKALRCQKNRQGDGGPPETSLAQGILLIFQALGRQIEARAKEVPDPALRHIFMMNNLQYIYTRVEKNRLKDFLDASWIYGIGRKVDNHTLKYQNDFCQKIVIHLNHEGLGGSSIGKSSVRSIVRQNLRAFSSAFDDIIRTQGNWVIQHESLRDSTRSYITRKILSVYRSYLENYGHLLGHFYSSNKFVKYTPEMVEQLLDGVFVPKRRSSSTLSLSNDS
The following text describes a protein:
Function:
Catalyzes the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via beta-oxidation, with malonyl-[acyl-carrier protein], forming 3-oxodecanoyl-[acyl-carrier protein], an intermediate of the fatty acid elongation cycle that can then be extended to supply all of the cellular fatty acid needs. The enzyme thereby shunts fatty acid degradation intermediates from the beta-oxidation pathway into de novo fatty acid biosynthesis.
Sequence:
MESFNTFVRQYNDQHAEAIAKGELEALAESSSAFIEKASGIKSRFVMNKEGILDPQRMVPYLPERSNDEWSILCEMAVAAAREALQRAGRSAADIDGVIVACSNLQRAYPAIAVEVQAALGIQGYGYDMNVACSSATFGIQAATTAIQTGQARAILMVNPEICTGHLNFRDRDSHFIFGDACTAVIVERADLAVSKHQFDIVSTRLLTQFSNNIRNNFGFLNRADESGIGKRDKLFVQEGRKVFKDVCPMVAELIGEHLAANEIQVAEVKRFWLHQANLNMNLLITRKLLGRDAEAHEAPVILDSYANTSSAGSVIALHKHQDDLPSGAIGVLSSFGAGYSIGSVILRKH
The following text describes a protein:
Function:
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAELTSTKLNAENHLLLDQPLLRLPHELARRNFKSVQRLVEREREYVIPALKEAANASLSNAQTPDQTLAALDSMLARMQNLKRKMESIQQEEKKVQNQSRKRIQHLEHLHQIPSLADVKYDQWSRIRLDRLVVDHMLRSGYTESAQQLAQEKGIEDLVDLDVFVQCQRIAQSLRRGETKDALQWCNENKAALKKSQFNLEFELRLQQYIEMLRTGDRGKLMDAMAHAKRYLTPYTETQSKEIHRAAGLLAFPQDTKAEPYKLTDLQSMYSFDRWNYLSDLFIRTHHELLSLPSSPLLHIALSAGLSALKTPSCHSAYTSSSSNFLSTTTSVCPICSTELNELARNMPYAHHAKSYVESDPIVLPNGRIYGQQRLLDMSKKLGCVETGKVKDPTTGEIFDKSEMKKVYIM
The following text describes a protein:
Function:
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity).
Subcellular Localization:
Cell membrane. Cell projection, ruffle membrane. Cytoplasm. Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli.
Sequence:
MLRSCAMRLRTLGATPARRPEATRRLFSSEEVVCKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRLPSYRQNPPQALQEFQTHFVDSKFKKEEQMSKAQQFTRSLEEGLGFEYAMFYNKAEKRIVCLFQGGLHLQGMPGFVHGGAIATIIDITAGMCAFSEGIVMTANLNIDYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSTDEKTLHTQATALFIKLDPDKPLT
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system CbrABCD for uptake of the siderophore achromobactin. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDKRGGMDHVLVWRQGRFSRQINLTTVGRVSLALLLVLAVMVASLGVGKLMLSPWEVLRALWSSQPEGAALIVQQLRLPRVVLAALVGGALAVSGLILQAMIRNPLASPDILGITSGASAAAVFYLSFLAATLGAHYLPLAAMIGAATAALAVYWLAWQAGVSPQRLVLTGVGVSALLMAATTFMLVFSPLTTTLSAYVWLTGSVYGASWRETRELGGWLLLIAPWLVLLARQVRVQQLDDGLAQGIGVRVQWLRVALLLLSVALAGAAIAWGGAMAFVGLIAPHIAKRLVAPGFAGQAAMAFLSGAGLVMVADLCGRTLFLPLDLPAGIFVSALGAPFFLYLLIKQRH
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Sequence:
MSSTELRRTALDATHRALGATMTDFAGWDMPLRYGSEREEHVAVRTRAGLFDLSHMGEITVTGPQAAELLNFALVGNIGTVKPGRARYTMICREDGGILDDLIVYRLEEAEYMVVANASNAQVVLDALTERAAGFDAEVRDDRDAYALLAVQGPESPGILASLTDADLDGLKYYAGLPGTVAGVPALIARTGYTGEDGFELFVKPEHAVGLWQALTGAGEAAGLIPCGLSCRDTLRLEAGMPLYGNELSTALTPFDAGLGRVVKFEKEGDFVGRAALTEAAERAASRPPRVLVGLVAEGRRVPRSGYRVVAGGEVIGEVTSGAPSPTLGRPIAMAYVDPAHAAPGTEGVGVDIRGSHEPYEVVALPFYKRQK
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.
Sequence:
MAVYKNEERGTYFCTFYYTDWTGKRKRKKKEGFKKKKEAADFEREFLNKQKNNCDMNFKELSDLYLEHSKTRIRVTTFQVKEIIIKERILPYFKDMNVNNITPNNIRKWQNKLMSKDYKQTYLKAVNKQLNAIFNFAIKYYNLNSNPALKAGPMGKKDSEGMQFWTLEEYKEFIKCVDNPMCKLAFEILFWTGLRKGELEALTFSDIDTKNKIISITKTYTRINKKDIINPPKTPKSKRKVSISDFLCEDIENYKKKLYNFDKNERIFPVGRHILKNSMRDACEKSSVKEIRIHDLRHSHASLLIELGFSPLLIKERLGHENIQTTLDTYSHLYPNKGASIADKLDDLF
The following text describes a protein:
Function:
Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDVPTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGLPRD
The following text describes a protein:
Function:
Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Binds to the mitochondrial cysteine desulfurase NIFS1 and increases its activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MATASRFLLRKLPRFLKLSPTLLRSNGVRVSSNLIQDSIEPLDSFWRIGSRIRHDSLTTRSFSSQGPASVDYSSVLQEEEFHKLANFTINHLLEKIEDYGDNVQIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPVSGPSRFDWDRDANAWIYRRTEAKLHKLLEEELENLCGEPIQLS
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMKTLSIQQITFPTTFMFQILGVYFGAKRKLLITVLYLSIFGYYLLDFAQFVTRPSKFALWRVLKIVTICRIIGSVFTIVVLVLAHVKYYKNLVKLAHDIETIDKSLVELGFEKYLAKASYRHHRTIIKLIIVTNVGLNVVLEAYPVWHMPHGKFGYCISNIYPKLLISTMTMTFYQFAIIIEERFKIINKLFENGVRSRVVLLHKSLIRISRRLNSIFAIQFLGLIVLSFIVITAEMHVFTYYFVFNVSSRFFIIVFVGLKNSLSSTIEICYLTKRCSRLCYEANRSKRILLGTRIDIFRENERNKIINLALKMMRSELKISACGLFTIDNSLLYSLFGSACSYIFVMLQFDRDN
The following text describes a protein:
Function:
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Subcellular Localization:
Cytoplasm; [Isoform 2]: Nucleus; [Isoform 3]: Postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note=The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity); [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed; [Isoform 6]: Nucleus.
Sequence:
MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPLVKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF
The following text describes a protein:
Function:
Member of the two-component regulatory system RR06/HK06 involved in regulation of target genes (By similarity). Has been shown in one study to not be required for regulation of expression of choline-binding protein CbpA.
Miscellaneous:
MISCELLANEOUS: Probably part of an rr06-hk06 operon.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGEKFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLKRDIVDKRLPLVHDLDIKDGKLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFSYFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGKQINGMYEHLLKVIHELESRNEQIVKLQNQKVSFVRGASHELKTPLASLRIILENMQHNIGDYKDHPKYIAKSINKIDQMSHLLEEVLESSKFQEWTECRETLTVKPVLVDILSRYQELAHSIGVTIENQLTDATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQELEHLFDIFYHSQIVTDKDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPRLKLVLKKTSKSKAFGKWVIRDVQPALQAPAHFKEVAVYFTESEWICLEEGQKELYKEVMLENYLTFNSLGYLHKKPDIISRIERDEDPCLSYNKDKRKSFHFDGARYGTDELCTSLFTQDGLAVEGLRLEEDKQVEQRDPSNESDRVSVTRRYNLRGNASMNYSSFYDDEPPETRALKPHKKLQMKRISSMTNEQLQKKGRRLYGCSECGKTYTQKSNLAKHQRFHTGIALYVCAQCEKCFTLRSSLIRHKKIHVVHKPFHCSDCGKRFTDNSTLLKHQRIHTGEKPFKCSECGKRFSISTYLIVHQRIHTGEKPYECSDCGKSFTQSAHLITHQRTHTGEKPYACIECTKCFTSSSHLVTHQRIHTGERPYSCLECGKNFKHSTHLVLHRRTHTGEKPFACTECQRRFAQRPQLLKHLQKAHSDDWDM
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGRAVGRAAFLFLFLSLTVAQNITKNGAGTLDVGVILHLKSLVGKIARTSVLMAVEDFYSVHRNFKTKLVLHIRDSNGDDVQAASEAIDLLENYNVRAIVGPQKSSEVTFVSNLGNKSQVPVISFTATNPALSSINVPYFLRGTLSDVAQVNTIAALIKAYDWREVVPIYEDTDYGRGIIPYLADALQEFGAFMPYRSAISESATTDQLERELYKLMTMQTRVYVVHMSLNIASILFAKAKDLGMMSEDYAWILTDGISNIVNSLNTSILEKMNGAIGVRFYVPASKELDDFTTRWNKRFKEDNPNDPPSQLSTFGLWGYDTIWALAQAAEKVRMADAIFRKQKDGKNSTSLGTLGISTIGPELLDSILHSKFQGLSGEFDLGNRQLEFSTFQIINVVGGRSKEIGFWITKHGIFRQINENISKTTNVNSMPGLNRVMWPGEVYTVPKGWQIPTNGKKLRVGVRTSGYPEFMKVERNTATNEITASGYAIDVFEEALKRLPYAIPYEYVAFDDGQGVNSGSYNDFVYQVHLGVYDAAIGDITIRYNRTSYVDFTLPYTESGVAMIVPVKDDRDKNTWVFLKPLTTGLWFGSIAFFIYTAVVIWLLERRINNAELTGSFFRQLGIAIYFSFFADRERVDSILSRLVVIVWVFVLLVITSSYTANLSSMLTVQQLQPTVTDIHELLKSGEYVGYRNGSYLSDLLEGLGFDRTKMRAYENPDEFADALAKGSQNGGIAAVVHEVPYIKIFLAKHCKGYTMVGPIYKSEGFGFAFPKRSPLVYDFSRAILNITEGDSIIHIEKKWIEDQHACQNDGTMIGSSSLNFNSFSGLFLVTGVASTSALLIALMMTLYKNKHRIRDSIRRGQTQKEYERETINEQNQERTIDSNQVQNLQLTVPDDSNEYTCQQEGEISIEISPASGIQTSQDIASHRTSRNG
The following text describes a protein:
Function:
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
Sequence:
MRPYSVSWLLLLLAGYSAFSTGVCVTDKKDYYEVLDVLSDAKSAEIKRAFRRLAAEHHPDKNKDPAAETRFREIVEAYEVLTDEHLRAVYDKDGYSGLEKFKRGQASSDSQRFRKGQFDVQIEEIIAELLMLFKFARQANNGPRGPKSLPFFIFSPKDGGFPFRFVEPWDLPTQKKGSRDKYKMGEKYPDRERARTHFRQMYSEEVNGGPNHEKNIFFYQKKMNGDARRNNEKIRHFAAEPRAFGKDHHNDHESPYDRENRAKENQRERHKTGRTFSKEHGDDFPGRARSMQENINFNKRSFHIHKDGRENGRKGTDIPDVRGYFPTSRLPTRQMKDRRTFIRDTLSKGKQRG
The following text describes a protein:
Function:
Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane. Endosome, multivesicular body. Melanosome. Extracellular vesicle. Secreted. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes. Sorted to stage I melanosomes following its processing in the ER and cis-Golgi. Transiently expressed at the cell surface before targeting to early melanosomes. Colocalizes with BACE2 in stage I and II melanosomes. Colocalizes with CD63 at exosomes and in intraluminal vesicles within multivesicular endosomes.
Domain:
The core amyloid fragment (CAF) represents the amyloidogenic unit of melanosomal fibrils. It is predicted to form a beta-solenoid structure comprising four coil right-handed beta strands with Tyr-151 and Trp-160 residues pi-stacking against each other to confer stability; The highly O-glycosylated repeat (RPT) domain drives the generation of the fibrillar amyloid sheet structures within melanosomes. The O-glycosylation sites rather than its primary amino acid sequence are conserved across species; The Kringle-like domain (KLD) contains six highly conserved cysteine residues that are critical for dimer formation.
Sequence:
MDLVLRKYLLHVALMGVLLAVGTTEGPRDRDWLGVSRQLRIKAWNRQLYPEWTESQGPDCWRGGHISLKVSNDGPTLIGANASFSIALHFPKSQKVLPDGQVIWANNTIINGSQVWGGQLVYPQEPDDTCIFPDGEPCPSGPLSQKRCFVYVWKTWDQYWQVLGGPVSGLSIGTDKAMLGTYNMEVTVYHRRGSQSYVPLAHSSSAFTITDQVPFSVSVSQLQALDGRNKRFLRKQPLTFALQLHDPSGYLAGADLSYTWDFGDSTGTLISRALTVTHTYLESGPVTAQVVLQAAIPLTSCGSSPVPGTTDRHVTTAEAPGTTAGQVPTTEVMGTTPGQVPTAEAPGTTVGWVPTTEDVGTTPEQVATSKVLSTTPVEMPTAKATGRTPEVSTREPSGTTVTQGTTPELVETTAGEVSTPEPAGSNTSSFMPTEGTAGSLSPLPDDTATLVLEKRQAPLDCVLYRYGSFSLTLDIVQGIESAEILQAVSSSEGDAFELTVSCQGGLPKEACMDISSPGCQLPAQRLCQPVPPSPACQLVLHQVLKGGSGTYCLNVSLADANSLAMVSTQLVMPGQEAGLRQAPLFVGILLVLTALLLASLIYRRRLMKQGSAVPLPQLPHGRTQWLRLPWVFRSCPIGESKPLLSGQQV
The following text describes a protein:
Function:
Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate.
Sequence:
MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFRPFIIADAGTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWASRSSMVIFSMRLATASTRRPAVGLSAKAFSAWSPTRSTRGGRTASSRSTAFSTRSSRGSWRPGRTTRA
The following text describes a protein:
Function:
Metalloprotease that catalyzes the second step (site-2 cleavage) in the proteolytic activation of various factors, after site-1 cleavage. Part of a regulated intramembrane proteolysis (RIP) cascade. After ER stress, cleaves BZIP17 and BZIP28 proteins which function as stress sensors and transducers in ER stress signaling pathway. The N-terminal bZIP component is translocated to the nucleus, where it activates the expression and production of ER chaperones, as well as proteins involved in brassinosteroid (BR) signaling, which is required for stress acclimation and growth.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MEISGRRMRRFRMRFRRDHLTGGENIENEASCCYCDLKISNFNEPIFRLGRRFSGVLKVWFSIGLGFGVASLILVTVFLLLQFHSNPLFSNRLTSAVFGFSPSTRVSLSGIAYVLVSTVITVSVHELGHALAAASEGIQMEYIAVFIAAIFPGGLVAFDNDVLQSLPSFNALRIYCAGIWHNAVFCALCVFALFLLPVMLSPFYKHGESLTVVDVPSVSPLFGYLSPGDVIVSLDGIQVHKPSEWLELAAILDKENSKTSNGSLYLGGSRRFHHGKGYCVPISLIEEGYKGKMVENQFVCPGDLTAFRTMPCSNAAIREVSVCLDAKDIVKLQKCGDGWVTTSDTDNQSDCVCPQGDLCLQAMQSPGVLWTEITYKRTSSQDCSRLGLDFNTSNCLGTFVFVGDLIAMSHSVHLTAYQPRWLFNFFGKSFPNILERSLTCTFHVSLALVLLNSLPVYYLDGESILESSLQSFTWLSPRKKKKALQVCLVGGSLLSFLAFFRIFLLGLPLSRRW
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS10 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.
Subcellular Localization:
Nucleus.
Sequence:
MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFETLPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQESPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQIENQHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSQIVDPWERLFKILNVVGMRCEWQMDKGRRSYGDILHRMKDLCRYMNNFDSEAHAKYKNQVVYSTMLVFFKNAFQYVNSIQPSLFQGPNAPSQVPLVLLEDVSNVYGDVEIDRNKHIHKKRKLAEGREKTMSSDDEDCSAKGRNRHIVVNKAELANSTEVLESFKLARESWELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSISQPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKSQEEPSKVKPKFRKGSDLKLLPCTSKAIMPYCLHLMLACFKLRAFTDNRDDMALGHVIVLLQQEWPRGENLFLKAVNKICQQGNFQYENFFNYVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQVSRCGENLMVVLHRFCINEKILLLQTLT