lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).
Subcellular Localization:
Cell junction, focal adhesion. Cell junction, adherens junction. Nucleus. Cytoplasm, cytosol. Cell membrane. Note=In adherent but isolated podocytes, targets to focal adhesions and then shifts to adherens junctions after cells make homotypic contacts. Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts several hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane.
Sequence:
MQRSRTAADDAALLLAGLGLRESEPTAGSPGRVRRGPRAVDEAAPASGRRGKGGCGGPEAAPDVPSRPERGPRASLAGSDGGSARSSGISLGYDQRHGPGPGPPSGGSARSSVSSLGSRGSAGACADLLPPGVGPAPARSPEPAQFPFPLPSLPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDCFICDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVDNNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVECYHCEDCGLQLSGEEGRRCYPLEGHLLCRRCHLRRLGQGPLPSPAVHVTEL
The following text describes a protein:
Function:
Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin. Plays a role in the regulation of the rest/activity cycle.
Miscellaneous:
MISCELLANEOUS: 10-fold less sensitive to cocaine than mammalian dopamine transporter SLC6A3.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSPTGHISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLNGVTTEVTVVRLTDTETAKEPVDV
The following text describes a protein:
Function:
Required for efficient splicing of pre-mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSGNSGASESISIEETNRIRISLGLKPLDISEEKPQKELSDASVKSSYVDQEQQAYENWKKQEQEEINRKKEEELKSKFEKLRQKNERRRRTQGKTLAETLAEEDDQIDANDTRAWILKMRNSSLNKNGNGLNFEAKNDAPRRSTLHSQNAGPNVNSSLEGMKIAHGFQDLNKNDGLVLTLKDADILDEDNHDLLENVEMVQRKTKNERKEDNPYKPYEDENDFLQQSEADQPSEDTFTTIGPQNSLTVNSTIEKHKSDNKKTFGTLVSFVEPTITGSEQSDYRQIKIKKSKKKKSKSDRRKRLVELDAENENENDPSDFVLPNGQSNSDLSVEQDSAIFKEQKKMKIQKRMRELETQSFADDDDLQQSIAMQRRLAQKRAKILKPEDVAEQLQNAEEVTDMTDSDTASGLIFDDTRAFVNSIKETENREALGSINEQAFEDSKDLNDTNSITGSSPTEESNALVEDTSVDISATLEEANTQQENAEDEPLVSDNVGAVLSLLRNKGVIKVSDEAKEKIQKEEEYNKWFARKQQARVELEEQRRKKKEQDRLSGKFEKMTQKEREQYAKKENERWDKKIAEIELEQFHDYKPQVDIKYVDEFGVELGPKEAYKYLLSHQFHGKGSGKAKTEKRLRRIVEKEREERKPIF
The following text describes a protein:
Function:
Acts as a transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MSSSSQASSRRQWCYLCDLPKMPWAMIWDFSEAVCRGCVNYEGADRIELLIDTARQLKRTHVMQDGRSPGPQPGGKHGPAGKEGPMEAGRPPSERYERGRGEYVSARLPNGLPRLEDGGPPEVSRQSPTARRTLVGAVPPNLMAQGLVGAPHGLLTAMPLNPRAGSAALTIPAPMLNEISKRQALSMGLSVGVPSFMAPEFEKEFKEKQRNAEALAELSESVRNRADDWAGRPKPMRDALHTLSGCTPFNVRFKKDHGLVGRVFAFDAKLMVEFELKIFIEYPCGSGNVFPSILALVKHMFHDSQKDTGKVINSGYKYVEYEKRHGTGDWRLLSELLSDAVRAFKEMPAPDALPQPYLDASCSMLPTALCHIGRPTQPRVRRRKASPDPDGAERMSSEELRQHWPLSAYPGIPGHMPATSLASAGQAPEGHGSDPSPITALMSVADNVGTASSKDGPGSSGHSANAGRQNSTSPSPGGGQRRLASRNGEPSAGSSTGGPATVTDQSAVMGGEGSAGGGGAPLCCTICQERLEDTHFVQCPSVAGHKFCFPCTRDFIRRQGPGSEVYCPSGEKCPLVGSNVPWAFMQGEISTILAGDVKVKKERDP
The following text describes a protein:
Function:
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Subcellular Localization:
Mitochondrion.
Sequence:
DPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
The following text describes a protein:
Function:
Collaboratively with AIPP1/EDM3 and EDM2, the AAE complex regulates alternative RNA processing (e.g. alternative splicing) and epigenetic silencing (e.g. H3K9me2) of intronic heterochromatin-containing genes as well as genic heterochromatin-containing genes by promoting distal 3' polyadenylation; may associate with intronic heterochromatin and bind gene transcripts to modulate polyadenylation. Required to prevent promoter DNA hypermethylation and transcriptional silencing of some transgenes. Plays a similar role to that of the histone H3K9 demethylase JMJ25/IBM1 in preventing CHG methylation in the bodies of numerous genes. RNA-binding protein that ensures the proper expression of JMJ25/IBM1 full-length transcript by associating with an intronic heterochromatic repeat element of JMJ25/IBM1. Also modulates transposable elements (TE) expression. Contributes to a unique mechanism to deal with the collateral effect of silencing intronic repeat elements.
Sequence:
MEESVASEGLEFKWGKKKGVGGKKKDVQFYESFTYDGDEYRLYDCVLVGNASEPDSTEPFIGMIIKIWEHANKHIPKKVKLLWFFKPSEIAPYLEGVPNVLANEVFLASGEGLGLANTNQLEAIGGKCSVLCISKDKRNPQPSDEKFNSADFVFCRAFDVGSCKVVDTIDDKIAGVDVKFIFNRACSEKEATAVQNIEADVNGKSDSLKPNGPLARGASGSVRKIEDSAFESSDCKENSNGCKEEKEKGHYQLAIKKSTLAEERSNKDSGSRGNHYNGKDQESEVKKQLTKQKSMPGEERYSNSFEASGSRTIHSISKKAQENDVKKQLTKQKSMPAGERYSQESSGLDDRPLKKQKLDGSVTVRDGWDTTILQNITSDGKKDTGSFKRPRDKVTIEEVPPEKRSFVKNRDLVVSVSEGKTTKTVTEKGISKKPSFGRAEDKMSADDNERNYQVTEVCRRPDAGKSKWFRSLPWEESMREAEKKGTVVLLQNLDPTYTSDEVEDIVYSALNQQCEARMIERTSVTIPHIGEALVIFKTREVAERVIRRLDEGCLLLSSGRPLVASFAKITPPGKPSLFSGHIKLHKTQTRREMRDAVATSHSSQPNNLEFDMAMEWCLHQARHEQASESVSKRQLEEMKSLRINFKLKLP
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKETQSFEEMMQELEQIVQKLDNETVSLEESLDLYQRGMKLSAACDTTLKNAEKKVNDLIKEEAEDVKNDESTDE
The following text describes a protein:
Function:
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Sequence:
MTRLWDTARRKRLNCPKVLTLVPVRKHRTEKSSKKRDWTICLIKPLIVHKCIICIGSNYNRKENLLLARRRLVDLFPTIRFTSEQETRPLFFRSPALFSNQVAMFFSEAEEERVRKELKAIEQSAGRRPEDKKEEKVSLDIDLLSFDDRVLKPEDLKREYVVKGLEELKYNQI
The following text describes a protein:
Function:
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor.
Sequence:
MKTLEEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKAKVTFRPDASTAEVHDEHIRGLLKVGAVVEARNQDGVYQEATINKLTDASLYTVVFDDGDEKTLRRSSLCLKGARHFAESETLDRLPLTNPEHFGTPVIGKKGNRGGRRSNPIQEEESSSSSSEEEEGDQQQNEELYGKVVCVEGVLTNDKKKSTWYPALVISPDCHEDVTLKKDNVFVRSFKDGKFYTVLRKDIRELDEDKAPKADAGLKPALDAAWEFQRNGAVPNTWRTEVKDESSSSEDEEEEEEEEQEEEASSEEEEEEVEPFPEEKDNFLQQLYKFMEDRGTPINKRPVLGYKNLNLFKLYRLVHKLGGFDNIESGSVWKQVYQDLGIPVLNSAAGYNVKCAYRKYLYGFEDYCTSTGISFRMDLPYKTGEKASCKTEVKAEEVISAGNTVSLNTPEEHKSITESERSCTRHLLKEEKTETVTPCEEKADISGENKEDEKHAEEENEMNEEVKQCMSTGETDVTEDVKEEPCEEPDDKDLSGDVSSQEWEEGQEFECYPPGMKVQVRYGRGRSLKTYDATVKESNLEGGEVLYLVHYCGWNVRYDEWIKADKIVRPANKNVPKIKHRKKIKNKAERERDRIERLADREDLPSSKNRINRLSKVNSGGDVFSKMEECVDKGNQQSIEITSILNGLPGSDSSTDDSEREEDEDADHDEDDDHPGAHKADPPQSQHWEKNSSPPEAPKTPADAEQEPTLQDSTEAPKRKELDTDASAGRRKKAENTSKSPAKGKTRNSRGGEWLQSGSPKKLEDRGESSSEDEPKGHPKNKSSPSKKYNGVKEKSKSRGAFWEIPEKRAKVSAGIEERSPGCRTKGQKDVWSSIQVQWPKKTLKELFSDSDTEAANSPPPAGPEACSESARDEEEEEEEEEKLQEHPSSGTNSVLNTPPTTPESPAAAEGPAEILPEVRAPSPPAALAASPPPVSLPEEPLMEEPAGGRSESDSSTVEVESLGGEIQEMNAEEGAGSPSKAFDGNMSCNSNSNCSLTLSNSSQQESEQKAKASSSQKRHKESQGGGATKKHKRSHKNLSLQPKKSRKAAHSSDSEDQCISESTAKSPPVKSSGAELKSSITHKCSSRTPPSGQQRYHKHTDTEHSHGRTRWSFQMSDLEKMSSLERISFLQEKLQDIRNHYLLLKSEVASIDRRRKRIKKKERETGAAAASSSSSSSPSSSSLTAAVMLTLAEPTVSAASQTAGVSVECR
The following text describes a protein:
Function:
Required for assembly of magnetosome chains. Regulates the dynamic behavior of MamK filaments (By similarity). May connect magnetosomes to MamK filaments (Probable). Moves from the cell poles towards midcell; movement does not depend on the treadmilling ability of MamK, suggesting MamJ associates and disassociates continuously from the MamK filament.
Miscellaneous:
MISCELLANEOUS: The gene is quite polymorphic, the central region is subject to recombination between similar Glu- and Pro-rich repeats; MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Magnetosome. Note=Tagged protein extends from one pole to the other, and is longer than the magnetosome chain. Correct subcellular location requires MamK.
Domain:
The gene is quite polymorphic, the central region is subject to recombination between internal Glu-Pro-rich repeats (Probable). The polymorphic central region is not required for function, small segments in the N- and C-terminus are however required.
Sequence:
MAKNRRDRGTDLPGDGDQKISTGPEIVSVTVHPSPNLAAAAKPVQGDIWASLLESSPWSANQGGLVETAQPPSAPIRSQDPVPVADLVNRWSQPIWRTAPLAGNAESSEEGVVAPSLTQSDSVLAVSDLVIDVQPETDAEVEVSIEPEPALVEPVIEIEAEAAEVEPEPAPVADLVNRWAQPIWRTAPLAGNAESSEEGVVAPSLTQSDSVLAVSDLVIDVQPEANAEVEVSIEPEPALVEPVIEIEAEAAEVEPEPAPVEPVIEIEAEAAEVEPEPAPVEPVIEIEAEAAEVEPEPAPVEPAIEIEAIRVELEPVLIDEVVELVTEFEYSQAESVASADLIANPAPAESSRLAELLDEAAAIAAPAVAVAVEATRQPNKITASVKKRAPVQEVPVEDLLGGIFGVAGSAVRGVFTIGGGFVDGVVKGGRLVGSNVVAGTRRLAQTIEVSCGSCSSPKCDAEDKNK
The following text describes a protein:
Function:
Plays a role in mitotic spindle pole body organization, possibly at the point of spindle pole body separation. Required for mitotic exit.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Also localizes to the bud neck and buds.
Sequence:
MEDSTEDIIKSFTLEQSPEIKPKPKSKTSDLTDIVYAMDDDSIKMKKFTIFDDKYDQNISDSEHDLTPIKRKRQSAQSAPPPPATKFSSSIPQKPTLSPKKLATSPTKNYTDHINQLRSGPNSPKKYQDDENIRSLKYEIKRLKQEQNLKLENLQHKIDYLTNERDELQNQLTSMSFENDKLTKKNRSLSHENNHLTLENSKLKTKEYSNEELQSENNKLQRVNSTLRNERDELVKDFNITRDKLKKYYDLYLHCQKAHAKEMKKRIEVDGDKPISDKPMADNSTNQELVDVLKKLSEMMIEQKKISEPSAAVEKDTTSEDKTPPIPNTANSSDTPRMVSDFLEDFIKRVFEEMSSNNKNTLSPKQAINSQTYSQPNNFSNNTVPPSQSAAYNPSNSQPAPPPQPATNFYSSSTPNTNGYNQSSQSDERPETFELPHVAKDHWLQRPTSERSTQSTKYMKMDPEDIRKLVSVITDQLKKEQKSEKPSNVVEMETPVEKCQCCHGNPRNVTDTNNNQKLCQSCLNKGDFTMSEFMGRSN
The following text describes a protein:
Function:
Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.
Subcellular Localization:
Secreted.
Sequence:
MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLEKSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAKLCEEHGILRENIIDLSNANRCLQARE
The following text describes a protein:
Function:
Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MSFSEKPPPGRLLLDDTVPLTAVIEASQNLQSHTEYIIRVQRGVSSDNSWQVIRRYSDFDILHSSLMVCGISLPLPPKKLIGNMDREFIAERQRGLQTYLDSITQHPLLSNSLTVKKFLDPSNYSANYTEIALQQVSMFFRSDPKWEILEPLRDMGWRIKKKYFLVKNKELPKEKYLLSWVDLGPDKVLSDKDLQSAMKLLTSFSTPYLCPLLFSNVSESSALLIRPFNESGCLRDHICKVKPRDSYLKKYCNPKRSQGLELEQIKLYGRQILEGLKLLHDNGMFFGHLHTSNVMVEEDVCQLLEVENGILGVPSMLRATFSQLRKINTTESIDVFCFGHSLYEMTYGRPPDSVPVDQFPAGPHTSVVSVLESILSSEACKSGMPSVSALIQTPLFIDVRLKQSEKLQIKVPSKLKEALRAAKEKLEKRLQEEQKLLHHHRRLTRAQSHHSSEEEKKRRKILARKKSRQTNVEHKEDISVPNSNNSGSGASSPPTCPSSPTPSSTTAPPPAPPVPDRSPTPPQPPLPDGAGGGRSALLSSIQAFSKGKLKKANTTDRSKPVI
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MLKYFILSLLFCVALAEQSATHQLLHIYPENDVHLTFLESLRNKYDVWYAASDRYDILLPLPQVQSLQIELQDAGLTSKIFIEDINKIIDDERERLRVKAPGFDYEDFNNLTMCNQELDKIAAKCIPGFVCTIDSIGDSTEKRPIKRLKISRRDSKRKIVWLDATTHAREWLTTATLFKIVKHMQDNYNGDSLVKSLLDKYDWHFIPIVNPDGYDFTWTQNRMWRKNRRMNMKPRCPGVDLNRNADNAWGTTGSGEDECSEIYRGPKVASEPETQALKRQYNLLGQNVLEVINIHAYGQYWMTSYGHVNPVTKKCYEAPDEKETVRIANAAADAIQEVFNTTWKRGPTCTTMYIASGLLIDDAKDRSGIRYTAVPEVRGNGFVVPPSEITPSFKEIWAGVTASIKAIEDGPFFSDN
The following text describes a protein:
Function:
Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Miscellaneous:
MISCELLANEOUS: Present with 1470 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDSEASDIEAELSDSVSAGGEEYIDDDDYTEDIDDQIVTAKSSRRTARRSVPKGVRTSKRIRDKELSVEVDEDYDEEEDVLSPSKKRHLHTRSMDKRQVAATASEKSDIGDSKGNDGEIEDGILEEEESLEKELNRGGGKEVEKSEESYYAQNDVGQKGEEEQDGESGGYEDNEPSISKESDELVSVVNGNGNEEDDEVEATKENTTDSTRSTTTRSKMLLDLLEDGGSKKKLTDEEIQLRRAENARKRKNLSEKRLEEEKQDTINKLLKKRAGKSRSHLPNDDEKNDGSSSFVKPRRPYNSEGMTRILRRYEEDLFCTF
The following text describes a protein:
Function:
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
APVLAGAARGRRPALCRERCGEPLAGFPSPVPDPGRRASSFLVLVAEIPPAGAQRSLSFPIHRVSPCPRIPIAGVWGAAVNSRSGEGSVGRSLSAGVPACVECGQPGDAVNCSDKQYEHKGRCCNRCQPGKKLASECNDTEDSVCTPCENGQYQQSWTKERHCTPHEICEDNAGLIVKRHGNATHNTVCQCRAGMHCSDASCQTCVENEPCKQGFGFVAAMAEARMTSPCEPCAEGTFSNVSSKTEPCHFWTSCEEKGLVVKVKGTNTSDVICESSRRSSLSVLIPITAAVVTCLVGICIYCLVHTDLRRRGPKQAEAEAPRELVTQQPEEVDFPVQETLLGGQPVAQEDGKESRIAEQEQL
The following text describes a protein:
Function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. Regulates longevity and age-associated decline in motor activity in mid-late life, by acting in motor neurons and through daf-16 in the intestine. When clustered in neurons, mediates ethanol-induced suppression of locomotory and egg-laying behaviors.
Miscellaneous:
MISCELLANEOUS: Its activity is activated by ethanol, leading to the inhibition of neuronal activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Synapse.
Domain:
The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor; The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity); The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity); The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site.
Sequence:
MGEIYSPSQSKGFNQPYGYPMNCNLSRVFMEMTEEDRKCLEERKYWCFLLSSITTFCASMILVVIWRVVTHLCCQRREKEFVEPIPAPEAVQINMNGSKHAPSETDPFLKQQEEKHLGWMTEAKDWAGELISGQSLTGRFLVLLVFILSIGSLIIYFYDASFQNFQVETCIPWQDSPSQQIDLGFNIFFLVYFFIRFIAASDKVWFLLEMYSWIDFFTIPPSFVAIYLQRNWLGFRFLRALRLMTVPDILQYLNILKTSSSIRLTQLVTIFVAVCLTGAGLVHLLENSGDFFKGFINPHRITYADSVYFVLVTMSTVGYGDIYCTTLCGRLFMIFFILFGLAMFASYVPEIADLIGNRQKYGGEYKGEHGKKHIVVCGHITYDSVSHFLQDFLHEDRDDVDVEVVFLHRVVPDLELEGLFKRHFTKVEFFTGTVMDSLDLSRVKIGDADACLVLANKYSTNPDAEDAANIMRVISIKNYSSDIRVIVQLMQYHNKAYLLNIPSWDWKRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSQTTPDWLNLYLCGAGMEMYTDTLSHSFVGMTFPEAVDLLFNRLGLLLLAIELKDEENKECNIAINPGPHIVIQPQTQGFFIAQSADEVKRAFFWCKQCHDDIKDVSLIKKCKCKNLALFRRNTKHSTAARARATDVLQQFQPQAPAGPMGHLGQQVQLRMINQQSSTSDTHLNTKSLRFAYEIKKLMPSSGGRRNSMSIPPDGRGVDFSKDFEQQFQDMKYDSTGMFHWCPSRNLEDCVLERHQAAMTVLNGHVVVCLFADQDSPLIGLRNFIMPLRSSNFHYHELKHVVIVGDLEYLRKEWKTLYNLPKISILNGSPLSRADLRAVNINLCDMCVIISARVPNTEDTTLADKEAILASLNIKAMQFDDTLGFFPMRHQTGDRSPLGSPISMQKKGAKFGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPETLSNRDRCRIAQISLQDNPYDGVVHNTTYGAMFTIALRRYGQLCIGLYRLHDQDNPDSMKRYVITNPPAELRIKNTDYVYVLEQFDPGLEYEPGKRHF
The following text describes a protein:
Function:
Inhibits several voltage-gated sodium channels and only one voltage-gated calcium channel (Cav2.2/CACNA1B (IC(50)=1.1 uM) and Nav1.2/SCN2A (IC(50)=3.7-80 nM), Nav1.3/SCN3A (IC(50)=88-5570 nM), Nav1.1/SCN1A (IC(50)=170-407 nM), Nav1.7/SCN9A (IC(50)=95.5-230 nM), Nav1.6/SCN6A (IC(50)=49.9-3990 nM), Nav1.4/SCN4A (IC(50)=113-400 nM or >10 uM), Nav1.5/SCN5A (IC(50)=1524-1634 nM or >10 uM)). The toxin acts by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the sodium current. It shows moderate affinity for lipid bilayers without cholesterol and high affinity for lipid bilayers containing cholesterol. In vivo, this toxin causes general ataxia, lack of response to stimuli, and semiparalysis. After a few minutes, the mice are unable to stand, and breathing is reduced in rhythm and intensity. Symptoms gradually increase with progressive slowing of breathing and flaccid paralysis; death occurred within 10 to 20 minutes post injection. Animals remain totally flaccid, and no symptoms of excitatory neurotoxicity are observed.
Miscellaneous:
MISCELLANEOUS: Negative results: does not inhibit Cav1.3 and Cav3.1. Does not or only weakly inhibits Nav1.8/SCN10A.
Subcellular Localization:
Secreted.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
DCLGWFKSCDPKNDKCCKNYTCSRRDRWCKYYL
The following text describes a protein:
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Binds to SNARE complex and then recruits NSF to disassemble it (By similarity).
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSSDPDKMMSKADKMTKLTLTRWSADWRGATELYEQAANGFRASNKYEKAKVALEKASKGQEMQASPWDAAKHMESAAALAQKLSIWNEVADFYRKASELYVECGRAQPASDALGKAARALEDVKPDDAIQLYTDACEILEEDGRDQMAFDLYRACANVYIKLEKFTDAATFFLRLGVAADKCDATNSQCKAYLSAIILYLYAHDLQQAEKCYNDCSQIDAFLKSDQSRSASRLLTAYNEGDIEEIKKVASASTVSNLDHMIIKLARKLPTGDVTAIQMNTNDDLDEDDLT
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSWKSLLSKNIKELRIQLSPAQTSAPGSNGIRDFILSNYKSIKAANPHLPVLIREAPGTEARAIARYAFGAERIISLENLTAAQVETQFKLLAETKPSSSEL
The following text describes a protein:
Function:
Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MPRDTFSSNPFISSPVYHDRSADISSFSYDARRYAPSPSSEALPQELPAGAMPAVADTFSVRNLSSYSQRPSMSTTPRMNSSFSGRDNQLEKDNLFGSSPTHFNSSSRLAYEAGPHSNYMAPEPLGYGRTRTKKPTRTCIPTNPTKRRLLFFGVPILLVVVAAAIIGGVVGSQKRHSASNDSSNGDSSSGTSGGGGSNSTSDTDANTWNSFIQPGSGGDGSIVTTDLGVNFTYSNAFGGTWAQDPYDPYSVSGQAQSWSPSLLEDWVWGEHIVRGVNIGGWLVTEPFIVPSLYEKYQTSTPKAIDEYTLSQAMGDNLATEMEEHYKTFITEEDFALIAGAGLNYVRIALGYWAVETIDGEPYLAKVSWNYFLKAIDWARKYGLRVLVDFHSLPGSQNGWNHSGKSGSVNWMYGVMGIANAQRSLETLRSIVEYISQDGVKQVVPMIGLVNEVQAETVGGDVLAAFYYQAYEMIREITGYGAGNGPVILLHEGFYGIAAWNGFLAGADRIGLDQHPYLAFPTTQIADNHTVQAHTACGWGGGTNDTSTGYGIVIGGEWSNAINDCGYWLDGVDSTPQFEVTGTGSCAALDEWFNYSDETKQGIMGYTLANMDALQNYFFWTWKIGNSTVKGYPTSPMWHYKLGLEQGWMPKDPRVAGGYCQSIGVGGNQFAGTYPASAIGSFPTEVATPTIDPTQVASHSVWPPTALGPSPSYSAAQITLFPTLTQTGTRNVLATPTHPSNVTLEGGWANAADTTGAWVRVAGCDYPDEYDANTVAVPTAQCTGSGSTDSMRKRSLRR
The following text describes a protein:
Function:
Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSTTAIRLAARPSSWRGTGALSSGRPLSQFASLPRRSINPSISGMRQGTLRLSIHDGRLFFSTQPPKDTPENMNNKETGSSNVIFMPPPPPAQTEAPSSGSAKEDTTDATNKSETETPTAASESETSKSSESDVSSASTSDSANSSETTTTTSETTPENGNNDTAQPELPSRTEAHRARLSARFSTIMDNFQTRLLTATQTLNDLTGYSAIEQIKRKNAELEVAHGQAQSRLRDARHNYKSLTMHRASTQREVTTLLARKDTWNPLDLERFTSLYRLDHELEAQVAQAAQELTEAETEESRLSADLNAGILKRYHEEQIWSDRIRRQSTWGTWGLMGVNVLLFLVLQFVAEPWRRKRLMKGIAENEKGVIDEVRHELGQVRQALEASGLRETAHLARLMEQEREIQALASTSSSSGDPQGGGGRTEGEVEMDIGAEFMAAAAEEAAEEAATAQQQQQQQQQQQQQQHHQTPETQEEPQQPPLTWKQTAQKWQQTLSDPQQIKAAVVDLYSDRRIDLKMRDVSLLALESAATGAAVVASVAFFVLRSSGSGKA
The following text describes a protein:
Function:
Component of the large subunit of mitochondrial ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRLSGVKSAVRARAAAGAAFSVSLSGPQAVSLLALPLVRHATKRAGGGKTNLKDSIGRRLGVKATEGTYVQPSDIIYRQRGTKFYPGENTWIGRDHTIYAKEPGYVRFYYDPFHPTRRFVGVGLTPEARLPTDHMAPRARRFGRNVISDPKRAEAELAWRPNKEQQLLEEISERRAVKQAEEQALTDKLAAKLKELGFDNSELAARAQKMAHYRTLGWTNAEAARFADAFLNTSSDVKDFDAKFEVTKFGTVVPKSSPETVEKELNETRDKLTKVRQPNAFISLSQIAKIDKILDATVYLSQSQKEQLADEFKVTASLLEAVQPHEEVVKAAKKGKGKLVKVYNVQRKGIDYVLAPKDAHFSEDIAFQKEFVH