lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) involved in glucose-induced cAMP signaling. Binds to its cognate transmembrane receptor GPR1, which senses extracellular carbon sources, and activates cAMP-PKA signaling and governs diploid pseudohyphal differentiation and haploid invasive growth. The G protein beta-mimic proteins GPB1 and GPB2 inhibit GPA2-GPR1 coupling, probably to reduce signaling in the absence of glucose.
Miscellaneous:
MISCELLANEOUS: Present with 4570 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MGLCASSEKNGSTPDTQTASAGSDNVGKAKVPPKQEPQKTVRTVNTANQQEKQQQRQQQPSPHNVKDRKEQNGSINNAISPTATANTSGSQQINIDSALRDRSSNVAAQPSLSDASSGSNDKELKVLLLGAGESGKSTVLQQLKILHQNGFSEQEIKEYIPLIYQNLLEIGRNLIQARTRFNVNLEPECELTQQDLSRTMSYEMPNNYTGQFPEDIAGVISTLWALPSTQDLVNGPNASKFYLMDSTPYFMENFTRITSPNYRPTQQDILRSRQMTSGIFDTVIDMGSDIKMHIYDVGGQRSERKKWIHCFDNVTLVIFCVSLSEYDQTLMEDKNQNRFQESLVLFDNIVNSRWFARTSVVLFLNKIDLFAEKLSKVPMENYFPDYTGGSDINKAAKYILWRFVQLNRANLSIYPHVTQATDTSNIRLVFAAIKETILENTLKDSGVLQ
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase.
Sequence:
MCEKAKKLVIGNWKDNETDAEKVQKKPFLKGTKSSIWGSSASDISGQSRSLKSSSSVLSSKFVTKRLFTIQHGIEGQKPNFKIRSESFSGPHSAGGFSKSTRESRSKSRSMGNGKFRGKSHLRSSSESAHSSGSESSSSDSNSGSSSDSDSTTGSSSHGSDTGERPRMRSAVFRIHETWQSPNSFKAVKTSRENKESRSRSSSLPQKRFCPSKTQNDLTYGSPEPKSPSNRGRNSWRVGMRTPWKKSQSRSMSCSSIQKILVSRSFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQPMDEVYNNAANYRKRHNITLTSWNMRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAECDLLVASAGRLLQMIDNKKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVGEINNIGVRLQNIRQRVEVVNGLSKVERLMKELTAIYDTSDIPGKVVIYVKRQKVVEELVDLIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGCLSYNRNCEVISFFTMANYKLVTEVVDFLKICKQEIGPHLLQLAEEKMFGPRQRRRHRPQRYNRMH
The following text describes a protein:
Function:
RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly.
Sequence:
MKPYSSGSMNGRSIAFFPGELNQKANKKKKKKKPKRRRRQRLIMLVQLPRLTSSLRDPFDVDQAYLRRKTILQTLNKPRSSGSRLDESDLARRIVHQWEGASPEVRQAYKQFIGAVVELIDREVQSEEFREVAFTAYRLFGKPVEEEEDSGFSDKSVAEKKLELQNVVGHAVSDANVKNVASFALALYSIQPAHQSEVYADVVDDGAEFGADLVFNLPSRFLVEESLGERGFENEESNSAHASFSEGWSDVSDMTKNQNAGKFDLSWLRDACGQMVRESNSQLSRDELAMAICRFLDSDKPGEEIAGDLLDLVGDGAFETVQDLIMHRKEIVDAIHHGQMVLKSDKTASNTQIRMPTYGTQVTVQTESAKQIEKLRRKEEKKNKRSAELGLESEISEANFSYLLEASEKNSGFDDLIGSGEANSLAFALPQGTVRKHLKGYEEVFIPPTPTAQLKPGEKLIEIKELDDFAQAAFHGYKTLNRIQSRIFQTVYNTNENILVCAPTGAGKTNIAMISVLHEIKQHFRDGYLHKNEFKIVYVAPMKALAAEVTSAFSRRLGPLNMVVKELTGDMQLTKSELEETQMIVTTPEKWDVITRKSSDMSLSMLVKLLIIDEVHLLNDDRGAVIEALVARTLRQVESTQTMIRIVGLSATLPSYLQVAQFLRVNPDIGLFYFDSSYRPVPLAQQYIGITEHNFAAKNALLNEICYKKVADSIRQGHQAMIFVHSRKDTSKTAEKLIDLARENETLDLFTNETHPQFHIRKKDVIKSRNKDLVKFFEAGFGIHHAGMLRSDRTLTERLFSDGLLKVLVCTATLAWGVNLPAHTVVIKGTQLYDAKAGGWKDLGMLDVMQIFGRAGRPQFDKSGEGIIITSHDKLAYYLRLLTSQLPIESQFISSLKDNLNAEVVLGTVTNVKEACAWLGYTYLSIRMKLNPLAYGIGWDEIIADPSLTLKQRALVSEAARSLDKAKMMRFDEKSGNFYCTELGRVASHFYIQYSSVETYNEMLKRHMNESEIIDMVAHSSEFENIVVREEEQHELETLARSCCPLEVKGGPSNKHGKISILIQLFISRGSIDAFSLVSDASYISASLARIMRALFETCLRKGWCEMTLFMLEYCKAVDRQLWPHQHPLRQFDRDIPFDTLRKLEERGADLDRLYEMEEKDIGALIRYNPGGRLVKQHLAYFPSIQLEATVSPITRTVLKVDLRITPDFIWKDRFHGAALRWWILIEDTENDYIYHSDLFTLTKRMARGEPQKLSFTVPIFEPHPPQYYVHAISDSWLHAESFYTISFHNLALPEARTSHTELLDLKPLPVTSLGNRLYESLYKFSHFNPIQTQIFHVLYHSDNNVLVGAPTGSGKTISAELAMLRLFSTQPDMKVVYIAPLKAIVRERMKDWKKHLVAPLGKEMVEMTGDYTPDLIALLSADIIISTPEKWDGISRNWHTRSYVKKVGLVILDEIHLLGADRGPILEVIVSRMRYISSQTERSVRFVGLSTALANAGDLADWLGVGEIGLFNFKPSVRPVPIEVHIQGYPGKYYCPRMNSMNKPAYAAICTHSPTKPVLIFVSSRRQTRLTALDLIQFAASDEHPRQFLSVSEEDLQMVLSQITDQNLRHTLQFGIGLHHAGLNDQDRSVVEELFVNNKIQALSSTYTLSVLVSTSTLAWGVNLPAHLVIIKGTEYFDGKTKRYVDFPLTEILQMMGRAGRPQFDQHGKAFLYEPFPVESSLKERLHDHFNAEIVSGTIGNKEDAVHYLTWTYLFRRLMANPAYYGLEGTEDESVCSYLSRLVQNTFDDLEDSGCLKVTEDSVEPMMLGTIASQYYLSYMTVSMFGSNIGPDTSLEAFLHILAGASEYDELPVRHNEENYNKTLSEKVRYRVDNNHLDDPHTKANLLFQAHFSQLALPISDYNTDLKSVLDQSIRILQAMIDICANSGWLTSSLTCMRLLQMVMQGMWSDQDSSLWMIPCMNDDLLGSLTGRGIHTLHQLLELPRETLKSVTGSFPASKLSQDLQRFPRIQMNVRLQRKDPNGPSTIEIRLEKISKRNTSRALAPRFPKVKDEAWWLVLGDTSTSELFAVKRVSFTGRLITRMELPPNITSLQDTKLILVSDCYLGFEQEHSIEQRPARR
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa.
Sequence:
MAPKKKGKKGKGKGTPIVDGLAPEDMSKEQVEEHIGRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQSSLTEMKAEGTVVMKLAQKEHRAQEGTLRRDMRALKVELKEQELANEVMVKNLRLKHTEEITKMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEIHEVEERKNGQITTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMGKKEEHLEKEMTEVAMQNRRLADPLQKAREEMSDMQKKLGSYERDKQILVCTKARLKVTEKELKSLRWEHEVLEQRFIKVQQERDDLYHKFTSAILEVQQKAGFRNLVLERKVQALVAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSAIKDLQYELARVCKAHNDLLRTYEAKLLAFGVPLDNVGFKPLDTAVIGQTLGQGPAGLVGTPT
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MYEYLDRRYALALYEVAEENNKVDEYLRDLKEVVNIIKNSEDICKILKHPEINTSRKKEIFTELFKDKVDDKILSFLLVLIEKDRILYLEEKLKEMEKIYLEKNNMILANIKTVIPLLKEEREELIEKLGNKYNKKIILEEEIDKSIIGGVYVRVGDDVLDGTLSTRLKDIKKMMLKRE
The following text describes a protein:
Function:
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
Sequence:
MEKNGHTESELQTQMVGNERLPQVTWQRKLNSKVKNPSEFKMSIRDVLHLFPLGYRLWRYTKEEAKKGRFSMYDIFKKRHVRGDHGVPLGGIGGGSIGRSYKGEFQQFKLFPKICEEAPILTNQFSVFVSRPGGLSYSTVLCPTKPKSVKGKTEDLGIESWDWNMEGDKSTYHALYPRSWTVYNEPDPELRIVSRQVSPFIPHNYKESSLPVSVFEFTMSNLGKEEATVTLLFTWENSVGGASGLTGEHFNSTIMERDGVHAIVLHHKTGNGHPPVTYAIAAQETEDVHVSECPCFLVSGHSPKEITAKEMWDEIKKNKSFDELNSEPGSPSRPGTSIGAAIAAKVKVPPGCDRTVTFSLSWDCPEVRFNEKTYHRRYTKFYGNLGDAAVKMARDALLNYVDWESQIEAWQSPILSDTTLPDWYRVTLFNELYYFNSGGTIWTDGLPPKESIERSKVTNTEQNDIVIDLFQKINAVCEQIYSPQSSNSEENIGQFIYLEGIEYLMYNTYDVHFYSSFALLSLFPKLALSIQRDFAATVLIQDPTKKKIMSSGEWVTRKLLGSVPHDIGLNDPWLELNEYNFFNTDRWKDLNAKFVLQVYRDVVATNDQSFAKAVWPSVYTAVAYLDQFDKDEDGMIENEGFPDQTYDAWSVTGVSAYCGGLWVAALQAASAFASIVGENAVAIYFNAKYEKAKIVYEKLWNGSYFNYDDSGSGSSSSILADQLAGQWYARACGLKPITKEEWIKKALETIYEFNVMKVKGGTRGAVNGMSTEGKVDTNSLVSKEVWAGTTYSVAACMIQEGQREKGFQTASGIYEAIWSDRGLSCSFQTPEAWNMNDEYRSLCYMRPLAIWAIQWALTRTQSFGEEKQKLVAGDEEEESNLLLRQHKGFKDVARFVKIVPTSNVHRSRLQHTYETVLKTLRL
The following text describes a protein:
Function:
Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
Sequence:
MSDSTSYLLHPPSEPGGTIPPDTDHSVSVSLPLWKHNVWYEMGIPEFLATFQTGYPRFLLNKYVKQLIEYVATVEHLNHSEDGETALLFPTMSVVNQCIEFVTTYGKLPAETLRVVDLKDVVAHDFGDLLDTKALNFSIYALIFRKADFPVVKQFWQHSGDGISSRRAEDALRILSDIRDRVNKRLVERSISHFKGKSRYSSKSDLQALNNCFQTDLKADEKKNLESDAALYLEERYARNMEASLAPAAKRVLRRRILGTLKDEVDLTKDIPETAVGETLRDVEGLTENDVYLFPAGMSAIYNAHRTIRLTFGNILKSVCFGWTYVDTMKVLEKFGPGSYFYGFNDEKRLDELEALLESGERVLCLFCEFPSNPLLNAPNLDRIRKLSEKYDFPVVVDETVGNFVNVEVLPMVDIVVSSLTKVFSGDSNVLSGSMVLNPHSRYYSKFKKTLDENYEDNLFDLDALTLERNSRDFEYRAKVINRNAEMIADLLHEHPKVKRVHYPKYNPSGPNFEARRTANGGYGGLLSVVFKNPDDAIKFYDTLKVAKGPSLGTNFTLASPYAVLAHFNELDWAEQAGGIDPHLVRISVGMEPEDHLLKVFEEALS
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MKREIEWNAIIELGVRPMSLKYGRDTIVEIDLNAVKHNVKEFKKHVNDEEIKMMAAVKANGYGHGAVEVAKAAIEAGIHQLAVAFVDEAIELREAGITVPILILGYTPVAAVEDVIQYDVMMTVYRVEDLHGINEIANRLQKKVQIQVKIDTGMSRIGLQEEEVKPFLEELNRMEYVEVVGIFTHYSTADEIDKSYTNMQTSLFEKAVNTAKELGIQIPYIHSSNSAGSMELSNTFQNMVRVGIGVYGMYPSKEVDHSVVSLQPALSLKSKVAHIKHAKKNRGVSYGNTYVTTGEEWIATVPIGYADGYNRQLSNKGYALINGVRVPVIGRVCMDQLMLDVSKAMPVQVGDEVVFYGKQGEENIAVEEIADMLGTINYEVTCMLDRRIPRVYKENDETTAVVNILRKN
The following text describes a protein:
Function:
Negative regulator of transcription elongation.
Miscellaneous:
MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The PHD domain is involved in the binding to H3K4me3.
Sequence:
MSVRTSSRSNKGQNKYIEYLLQEETEAPKKKRTKKKVDSAIEKNKKSDSSQEPRKDTENVRTDEVDEADEGYVRCLCGANNENYDAAEYSHGDMVQCDGCDTWQHIKCMTDGKDTIDGLMSEDSKYYCELCDPSLYAHLETSKEAEVSEDEDYHDDVYKPVNDHDDNDADVFLDEESPRKRKRSPDSAKGIHIKSKQVKKSNGSKKRNKSIDAAKSDTAENEMPTRKDFESEKEHKLRYNAEKMFSTLFSKFIVPETIEAKLYELPDGKDVISISQEFAHNLEEELYKACLNVEFGTLDKIYTEKVRSLYSNLKDKKNLELKAHVVEGKLPLNKLVNMNASELANPDLQEFKEKRDKIILENFIVEVPDKPMYVKTHKGDELIEDIAEPQEDILYSKDSIRLHNIDSIDSDKSKIEQTHAISKEPSPSTIINEESLNCAFLYPGLGLEFTGYLNYIGASQKLRRDIFKEAIGDGKLYVEGRLPTTTAAPYLKEISCSRAILVYQLFPSNDSESKTTFADVVDSLENKGRIAGIKPKTRYEKDFYIVPSKGGEIPEILKDILGSHNDERSERFSRMKSDERTLFAFVVVKQEFIH
The following text describes a protein:
Function:
Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG).
Sequence:
MSKKIAVIGECMIELSEKGADVKRGFGGDTLNTSVYIARQVDPAALTVHYVTALGTDSFSQQMLDAWHGENVDTSLTQRMENRLPGLYYIETDSTGERTFYYWRNEAAAKFWLESEQSAAICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRANGGKVIFDNNYRPRLWASKEETQQVYQQMLECTDIAFLTLDDEDALWGQQPVEDVIARTHNAGVKEVVVKRGADSCLVSIAGEGLVDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAENAAKRGHLTASTVIQYRGAIIPREAMPA
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5.
Sequence:
MKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDEALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS
The following text describes a protein:
Function:
Plays an important role in membrane trafficking through the secretory apparatus. In complex with CCZ1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.
Miscellaneous:
MISCELLANEOUS: Due to the stability of its transcription during plant development, this gene is proposed as a reference gene for transcript normalization.
Subcellular Localization:
Endosome. Prevacuolar compartment.
Sequence:
MATSDSRSSPSSSDTEFADPNPSSDPETNSERVQSQLESMNLSQPSEVSDGSHTEFSGGGDDNDDEVASANGNEGGVSNGGLLREGVAGTSGGEVLLRAENPVEMEAGEEPPSPTSSGYDGERGSSGGATSTYKADDGSEDEIREANVDGDTASQHEAAWLPGKRHVDEDDASTSWRKRKKHFFILSNSGKPIYSRYGDEHKLAGFSATLQAIISFVENGGDRVNLVKAGNHQVVFLVKGPIYLVCISCTDETYEYLRGQLDLLYGQMILILTKSIDRCFEKNAKFDMTPLLGGTDAVFSSLVHSFSWNPATFLHAYTCLPLPYALRQATGTILQEVCASGVLFSLLMCRHKVVSLAGAQKASLHPDDLLLLSNFVMSSESFRTSESFSPICLPRYNAQAFLHAYVHFFDDDTYVILLTTRSDAFHHLKDCRVRLEAVLLKSNILSVVQRSIAEGGMRVEDVPIDRRRRSSTTNQEQDSPGPDISVGTGGPFGLWHFMYRSIYLDQYISSEFSPPVTSHRQQKSLYRAYQKLYASMHVKGLGPHKTQYRRDENYTLLCWVTPDFELYAAFDPLADKAMAIKICNQVCQRVKDVENEVFLQGASPFSW
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPYFASLHTGYLSRGVFSVRIQRIYYPDQLSVDSTVTLDSRNYHYLLNVLRLREGHKIILFNGDGNNYGGRITRIQKKQVEITIDSKEAGRTESSLFIELGQGISRSEKMDYAIQKAVELGVNRIVPLITERTSTKPKTQKLAHWQGVLISGCEQSGRCCIPELMQAQSLSDWLSQKREGLSLVCHPNAQNSLADFKTTSQRITLLIGPEGGLSDDEVQRATQSGFQVLFLGPRILRTETATVTALSLIQAYFGDLQRL
The following text describes a protein:
Function:
Oxidase that performs selective oxidation of the terminal primary hydroxyl group of several alditols, with a reduction of O2 to H2O2. Shows highest activity on xylitol and D-sorbitol, and a poor efficiency with D-mannitol and L-threitol.
Sequence:
MSDITVTNWAGNITYTAKELLRPHSLDALRALVADSARVRVLGSGHSFNEIAEPGDGGVLLSLAGLPSVVDVDTAARTVRVGGGVRYAELARVVHARGLALPNMASLPHISVAGSVATGTHGSGVGNGSLASVVREVELVTADGSTVVIARGDERFGGAVTSLGALGVVTSLTLDLEPAYEMEQHVFTELPLAGLDPATFETVMAAAYSVSLFTDWRAPGFRQVWLKRRTDRPLDGFPYAAPAAEKMHPVPGMPAVNCTEQFGVPGPWHERLPHFRAEFTPSSGAELQSEYLMPREHALAALHAMDAIRETLAPVLQTCEIRTVAADAQWLSPAYGRDTVAAHFTWVEDTAAVLPVVRRLEEALVPFAARPHWGKVFTVPAGELRALYPRLADFGALAGALDPAGKFTNAFVRGVLAG
The following text describes a protein:
Function:
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPTPTPTPAPAPAPAAAPAGSTGTGGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLSLDSAGAEPMPGEKRKLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK
The following text describes a protein:
Function:
Part of the ABC transporter complex HisPMQJ involved in histidine transport. Is also part of the ABC transporter complex HisPMQ-ArgT involved in lysine/arginine/ornithine transport. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSSTH
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSVSWTTEQNNRFPKLNNDKGIGLPVSSHHRMMTDKIGLVIFGIVMIVLIPFLAYTLSKSDIRRLNQPYDSCGDFCGENNENIDGVNCSGKDLREKPFLSYNIWNNDFICSKKNMSYFFVNTDSSNKTKIISQYLLNYDFEEWDKFLITTLITGALCTLIMILFRFVPGLIVWGVIILGVILLFVISYLFWFASVYNEYKPSYTYPAIFFTVFTFVIIFILYALYKKIQLIKLLYGETAKAIFGIPFVLCLPVITFLIQFALVALLVLSLSYMFTAGVPVSYGDDRYKFELNDAMVFTIIFTCIVAAWGLEFLAGCQYMITAGSVAHWFFKKKTSRCIILTSTINTLKFHLGTIVIGSVIVMIINIIKFLLKSIGKLKYCCCGACTCCTPTTCSPCCCDCQTVINIIKYLSKNAYIETAIRGKPFVASGKRAVTLLFKNAVSMIALNYVGDFILAITQFVLIAISTGIAYLFFMDKPYLTFISFVINIIIVFVLFSTFQTTVDTLFICFCEDKLCSNGVSKPYRMPKNLMKFVNDSQKLYNEKH
The following text describes a protein:
Function:
K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system. Active in lysosomes where it regulates lysosome numbers and size. In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux (By similarity); [Isoform 2]: Does not display channel activity.
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Domain:
Each subunit contributes two pore-forming domains 1 and 2 which assemble to form a single pore with M2 and M4 transmembrane helices lining the central cavity and M1 and M3 facing the lipid bilayer. The transmembrane helices are bridged by the selectivity filters 1 and 2 that coordinate the permeant ions. Up to four ions can simultaneously occupy the selectivity filter and at least two elementary charges must translocate across the filter to convert it into the open conformation.
Sequence:
MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR
The following text describes a protein:
Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MGKSQSRPGSNWSWSYKRRENPEGDSYILRGCINARYRDSEEHLWTADGAPDQIPGCKNHHHGQHYGCDGRQSERPMALHRDLCSLKVDLPPEVTGSRCSLKVQTRQEDSPSKKLPPSSPTSPTIGAVDCDVSLDAEKETQEWAFTLYDFDGHRRITREDLSSILKSISEALACSVILPPSGSRKLKLRLSMLSDHERDTRKKTADKASQPSTPSHDNLSQQQSVGTQSTSLPSASPLDASQLFNKQENKENLFNRVRDRGDVPTHRHSFNVNHQCWRKEEKRSRRSKHRSHSMAPTDVTAPLYVDQQASPERHHRKARKSSAGVENGANKMATAVSKQTNNAGTNCVPVERPQENAERRSYYQELAGIDHQCTNHEQDAGAQQHNDPETELPLGASASSPNQVSHRHLKSSPHHRRAKTCDPQVHGFKKQTLQMNQELFAKYEYAQRHHKDYHMQLLEASRTRLEGMQPAGPMQAVAAGAEATFCHHSPKQHSFPAEPVQVVTTQVVAPATQAPPVSRGKHRRRSRRHHTLQPLTVMKHEVMEKTEGVGCSPVTQKHQHHHHHEHHHHHHYHHYHDID
The following text describes a protein:
Function:
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway.
Subcellular Localization:
Nucleus.
Sequence:
MVMYARKQPRLGDGCTDRRDSQPYQTLKYSSKSHPDHRHEKMRDSNDATPPCKMLRRSDSPDNKHMDNTGHGRAKAIHPHRGREREGGTSISPQENSHNHSSLHSSNSHSNPNKSSDTPFEPADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEATKTAAVVNSFPKDRDYRREAMQATPASYSSTKSSIATEKPSSLTPSSSSAAVSGLDVPNSASSASGSTVPVSPVMQSPAPPTLLQDPSLLRQLLLALQTALQLNNASVDMAKINEVLTAAVTQASLQSILHKILTAGPSAFNITTLLSQATQLSNQVAQQSSQSPMSLTSDASSPRSYVSPRISTPQTNTASLKPPLSTTPVSSQTKINAMTVKSSSLPPPSSQQPLSTEKHHDNGNSPRTLQRQSSQRSPSPGPNHMGSNSSSSSNNGGGGGGQGPGVVSGAMPPGSVPPGTAPGRATCSFTPTLAAHFNENLIKHVQGWPAEHVEKQASRLREEAHTMGSIYMSENCTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV
The following text describes a protein:
Function:
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage; Reconstitution in planar bilayers with lithium dodecyl sulfate-solublized P5 yields narrow pores (58 pS conductance) with a low probability of opening, whereas n-octyl-bD-glucopyranoside-solubilized P5 forms large pores (1.1 nS conductance) with high open probability. The large pore easily converts to the smaller pore at room temperature; at 42 degrees Celsius the smaller pore converts to the larger one.
Miscellaneous:
MISCELLANEOUS: Cross reacts with antisera againt E.coli OmpA.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Domain:
The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins.
Sequence:
MKKTAIALVVAGLAAASVAQAAPQENTFYAGVKAGQASFHDGLRALAREYKVGYHRNSFTYGVFGGYQILNQNNLGLAVELGYDDFGRAKGREKGKTVVKHTNHGTHLSLKGSYEVLEGLDVYGKAGVALVRSDYKLYNENSSTLKKLGEHHRARASGLFAVGAEYAVLPELAVRLEYQWLTRVGKYRPQDKPNTALNYNPWIGSINAGISYRFGQGAAPVVAAPEVVSKTFSLNSDVTFAFGKANLKPQAQATLDSIYGEMSQVKSAKVAVAGYTDRIGSDAFNVKLSQERADSVANYFVAKGVAADAISATGYGKANPVTGATCDQVKGRKALIACFAPDRRVEIAVNGTK
The following text describes a protein:
Function:
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.
Subcellular Localization:
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Mitochondrion membrane; Single-pass type II membrane protein.
Sequence:
MDALLAPAPVLLAGGGTLVSVAAALFVYYLRPAYILILLRWYNVWKTGFKIKFIKAAGRQIGYMERGQPKEGEPSMLFLHGFTDRKETWCEIIKYLPEHLHLIAVDLPGHGDTEIKPDDDLSFKNGLVILHQFVGAVGLESFHIVGCSMGGAAAGCYAGSHPELVSAVTMMCPAGVRTPPLEQIGPLLIPESTADIKEMLDRVFYNWKTVEPPEMILEGLLELRRPRHDFFRKMLEESKKTPNILEKEYMDKITAPTQVIWGKHDQILPPSAAAVLEKGIPNCRVDMLERCGHAPGVERPRKTASLLMHFRESIFS
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRFWSLLIVAWLPVLQVLLVGLLGALLASHRFNVLTSDARRNINKIVYIVFVPSLVFSSLASTVTLKDIISWWFMPVNMGIIFLFGAVLGWVSVKAFRPREHLQGLVIASCSSGKMYSDHRETKRFLEFSFSVFMFFACSISGNWGTIPLMIVPAICNEEGSPFGDANTCNLLGLSYVSLSMALGSFYIWTHSYSVMKRSAKMYKAKCKNHAQTDTSKEHFGQDATASFLRRANDLLVGILKELWSPPSIAADNMKSLVTEEGIGKTMIEPIMVISIIVIRYIILPACGIGIVTVATKLGVLPRSPLYRYVLLLQSTVPPAMSIGTIAQLFDVGEEECSIIFLWTHLVAALALTLWSTVFMSLVL