lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MARIPEEVIDQVRNQADIVDIIGNYVQLKKQGRNYSGLCPFHGEKTPSFSVSPEKQIFHCFGCGKGGNVFSFLMEHDGLTFVESVKKVADMSHLDVAIELPEERDTSNLPKETSETAKMVEMHQLTAKLYHYILMETEEGTAALTYLKERGMSEQMMTTFQIGFAPNHHATITSFLEKRGMDLQLAGAAGLLSERDDGQMVDRFRNRIMFPITNDRGQIIAFSGRLFDRDDGPKYLNSPETPVFNKRRILFHFSEARQAIRKQEEITLMEGFMDVISAEEAGVQNAVASMGTSLTEEHADLIKRLTNRAIICYDGDRAGIEAAYKAGTLLVERNRLDVFVLQLPAGKDPDDFIRASGPEKFKEVYKQQRMTWTAFKIHYLRKERNLQNETEQIGYIDDCLREIAKLDQAVERELYLKQLADEFELTIETLKQQLQQSLKNSQKSRQMASYNEPPIDDSFMGMMPQEGAEMLFSFEQPAQKLSAHTISEQQLMKAMMESRDNFLLIKQLLGDTTFYHDNYEALYTYLIGYFAEGNDADPTKFMDSVPDAAMKGLISSLEMVISPDEQGKPQFEDYIRSLKRYKLEQKKKELEQELATYNRENDNENEIRVMLEIVQLNRQLNSGQLD
The following text describes a protein:
Function:
Part of the ABC transporter complex OppABCDF involved in the uptake of oligopeptides (By similarity). Probably responsible for the translocation of the substrate across the membrane (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDRNKSFDPNLFKRVDINLLKRNDQLIGKPTTNSIEIIKRLFQNKWAILFFLLIVVIVLLAIIVPLTSPFSAVTPVSTNALAQNLPPRYLWHKPGDILVHKITARSIAEISQASGVLVGTLPSANSNPLATNVQYDIAPFQLQELRNYFPLLGTNGLGIDIWTLLWASVAKSLWIAVVVAIIAMVFGTIYGAVAGSFVGHMADNIMSRIIEIIDIVPSILWIIVLGATFRFGGVKQFDDSVVIFTLIFVFWTWPATTTRIYILKNKDTEYIQAAKTLGAHQIRIIFVHMLPVVFGRLAVVFVSLIPAVIGYEASLVFLGLKPATDIGLGALLNQVTSSDNVALILSSIVSFAVLTVAARTFANALNDAIDPRVVKR
The following text describes a protein:
Function:
Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites (By similarity). Required for normal embryonic development, including normal development of laterality, normal body size and shape, as well as normal brain, heart and kidney development. Required for normal development of stereocilia and kinocilia in sensory hair cells of neuromasts in the posterior lateral line organ, and thus also for balance keeping and normal swimming behavior.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Cytoplasm, cytosol. Note=Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity). Colocalizes with the actin cytoskeleton. Recruited to the cell membrane via interaction with pacsin1. Detected at the apical surface of cells at the basis of forming cilia, but not in the cilia themselves.
Sequence:
MNLGDATTRPPVGRRMKAQAPPPPRPPQPAPRRIFRNAVPDGGGSSGGDCKENMLRSYVDLHISLPTGYQTTINVDGRKALMDLLVDLCSQYHLNPAYHTLELLSPDAQPVSFKPNALLGALDVSCALIKERVLEDRVIRKPPPKVPEKTVRLVVNYHRSQKAVVRVNPLAPLQTLVPVICQKCEFDPAHVLLFKDNINHQQLDLDKSLSDLGIRELYVLDQTLVLQPKMASTPALNYSAESLRSNSLSGSEKKGLLGFLKFNRRKSKGMSVVASGPCVEARPSTLGQSQSVMNISKMSPKVELKKRRAPAPPPAPTQTLPPTSQISLGSPSSHNLLKKRKAPAPPPTPPPSTPEPDISTYVPTATVQEHYIPASVERTPRASTPADDSDLSHSIEDSEPARSICSSSSGDDAAAVGSSSSSLAEEPVTHRADVIAPFTTSTPEPEPKPEYEPELKKEASPRSTPELEPGPRPEVPAAEDLEVEMELKMEETENNRHSGIAWLHSAHESVLERRVQQEVETVSVASSESFADHGYAASEDMAEESGPVSPSERMQSVSPMDIMSLNSDSTLPVKQSKESSSDSDEGCATWGSRQSSGHIQDGQKSIKRQNGYEEDPEITAQIHLTLADLDANLADLNHSDGASVFVDDEIPVSIVDMDIPVTAIDEVLDDDQCSASECESVLLRSTQSISSKPCTPCGVIQNKNNNACLTEEKHRSPFPDIEKQLQTATLTVIDKPTIQSPTSKKPSQDAKITDNMEQKTTFNSEAKSKSETVELTSQKDTVLQKSQSFVRPDVQSVQKERTSSTRVLPTQGKITLSSFSRFGMKTFTVIPPKPAVSQTKPAGSLVTGAIKIDEQGNMVTQRQISSGPEKNNTPSVDTTRADKTPLVKAKAFWSTTEKQEKLTTAKTEPIVNNGDTDVFKASAVTGSFKLSPPEETHKEVIIVERKPISGVASKPSFSENHAEKRDLSFLIPSRRTSSQYVASVIAKNNKNSSIPKTKIDTTPAPLSISGVQNPVNQLLNNEVKPTSIHKPAVTVKPTENPVPSFRPKCLQSYVAEKPTSSERISTLHGGDKTKSLDSQPLSIKIQPFPHVSAHIKSFSEEATSINNFPDTSSARQTPTDTTHPPLAKKPELHKSEIPSEPNQGNVFGPVKKFKPVIFKPVQQETSIHSSLMEAIQSGEGIERLRKVSDLPTSCTVKKPSYNDPENERSALLSAIRASSTSAKLKKTKSVASKELEQLRKVEEDRNVHTEVISPRPTSPDFVPPLPPSFSPPPPPPPPLAPAKPPVVLPPGGNPEAAREALLEAIRSGSGAQQLRKVPVTQTRRQVNGRLGTIQATSPLSYGH
The following text describes a protein:
Function:
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The UBC-RWD region (URD) region mediates interaction with FANCI and FANCD2.
Sequence:
MAVTEASLLRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVLPEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQHSPDLMSFMMELKMLLEVALKNRQELYALPPPPQFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAEDASGREHLITLKLKAKYPAESPDYFVDFPVPFCASWTPQSSLISIYSQFLAAIESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEKSDFTMDCGICYAYQLDGTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNIIFGECPYCSKPITLKMSGRKH
The following text describes a protein:
Function:
Binds, preferentially, to the Maundrell ARS consensus sequence within ARS3002.
Subcellular Localization:
Nucleus.
Sequence:
MGKIKRRAITEHEKRALRHYFFQLQNRSGQQDLIEWFREKFGKDISQPSVSQILSSKYSYLDNTVEKPWDVKRNRPPKYPLLEAALFEWQVQQGDDATLSGETIKRAAAILWHKIPEYQDQPVPNFSNGWLEGFRKRHILHAINEQPTESVVLNNTEPPNDPLSRVYDVTRLTNINDIFTMQETGLFWKLVPNGTPEVEDIKGITRFKARITLTVCCNASGTERLPLWVIGYSQSPRVFRAANVKPEVMNFKWRSNGKASMTTAIMEEWLRWFDACMEGRKVILLIDSYTPHLRAVENIRNSGNDLRNTTVITLPSTSASISQPCSEGVIYALKACYRKHWVQYILEQNELGRNPYNTTNVLRAILWLVKAWTTDISPEIIENAFNLSGVLGLFNESAVTSRALDEMIHPLRELVSEFSVQAAMRIEDFISPSEENIVDSSEDIINQIASQYMDDRAFETDEEESTEFQITTKDAMKAIELLLNYEAQQPDGNPAITISLLNYQKLLEARGGNVNLSRLRST
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MMAAVKSTEAHPSSNKDPTQGQKSALQGNSPDSEASRQRFRQFCYQEVTGPHEAFSRLWELCCQWLRPKTHSKEEILELLVLEQFLTILPEEIQTWVREQHPENGEEAVALVEDVQRAPGQQVLDSEKDLKVLMEEMAPLGATRESLRSQWKQEVQPEEPTFKGSQSSHQTPGEQSEAWLAPQAPRNLPQNTGLHDQETGAVVWTAGSQGPATCDNRAVSLCQQEWMCPGPAQRALYRGATQRKDRHVSLATGVPWGYEETKTLLAILSSSQFYGKLQTCQQNSQIYRAMAEGLWEQGFLRTPEQCRTKFKSLQLSYGKVRRGRVPEPSIFYEEMNALSGSWASAPPMASDAVPGQEGSDIEAGELNHQNGEPTEVEDGTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRLGFEIKNEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRNSPGESEEKTPSQEKMSHQSFYARDKACTHILCGKNCSQSVHSPHKPALELEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGFSERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTHTGEKPYRCSHCERGFTKNSALTRHQTVHMKAVLSSQEGRDVL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSFDGCTPRCSPLSSPWRRLGEEEEGTSYLERWRQATLVINAIQRFKCNSEQCVQMTSQSSPNSPSRKFRLGTNVIRAIFRFKEAGKLAGIDRKELVTLVADHNLELLEQLGGVDGLAKALSTSTKNGIEDEVPKIERRRLLYGSNTYPQQSPKGFLAFLWEACQDLTLVILGVCAVVSLALALATKASWYDGASIAFTVILVVCVTACSDYKQSLQFQRLNAEKRKIHVEVLRGGRRIGVSIFELVVGDVVPLKTGDQIPADGVLVEGYSLVVDESSLTGESDPMSKGLDHPFFMSGCKVVDGYGTILITSVGINTEWGRAMAALTDDISDEETPLQMRLAGAATVIGAIGLAVAIICFSMLFIRYFVEDYKKDKKAVAVFKRNVNILSVAVTILVVAVPEGLPLAVTLSLAYSMRKLMTHKSLVRHLAACETMGSATTICSDKTGTLTMNQMTVIESWVAGQTRSFHEIRGLPDAVTSVIFDGVAHNSAGSVYYTLDRNGVPEVAGSPTEKALLSWGLQLGMDYSTVRAASSIIAVEPFNSTKKMAGVAIKRNNGTLCALWKGAAEIILDLCENWLDGEGTEKVLSSEMVSSIHGTLTHMAASTLRCLAFAIKTYNSMDGRPIPTAGLTFVALVGIKDPCRPGVREAVRKCQDAGVKVRMVTGDNVLTARAIASECGILMPGGLVCEGSFFRNLTDNERFQIVPKIDVLARSTPSDKLLLVKTLKSLNEIVAVTGDGTNDAPALREAHIGLSMGIIGTEVAKESSDIIILDDNFASVVKVVHWGRSVYENIQKFIQFQLTVNLAALSTNLVAAGRSENVPLNTVQLLWVNLIMDTLGALALATEPPTEEMMERAPIGLSEPLVTNVMWRNIFGQVAFSNSSSSFSVKSLHYFRQAAYQVAVLLVLYFRGDQILHLKGSPAQKIVLRNTIIFNSFVLCQVFNEINARKLQKLNVLKGVFQSYLFCTVIGVTSVIQIVIIEFLGKYFKTTRLVIHYWLLCVGIGFLSIPLACLMKLVHVPKKPIFNANWSRRRRRPQHPGTDTNGTCWEWKKWNKNQSRGFEHAVQVEQ
The following text describes a protein:
Function:
Acts specifically as a negative regulator of skeletal muscle growth.
Subcellular Localization:
Secreted.
Sequence:
MPKYSFLLCLVVLISLGKSGSDEPNLQLPPGSETPSDAGLSLLDEDAGSHECSACVWREQSKVLRLETIKSQILSKLRLKQAPNISREVVNQLLPKAPPLQQLLDHHDFQGDATLQDEFMEEDEYHATTESVITMASEPEPLVQVNGKPSCCFFKFSPKLMFTKVLKAQLWVYLRPLQQTSTVYLQILRLKPVTEQGSRHIRIRSLKIELNSRVGHWQSIDFKHVLQNWFKQPHTNWGIDINAFDESGNDLAVTSLRPGEEGLQPFLEVKVLETSKRSRRNLGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQHANPRGSAGPCCTPTKMSPINMLYFNDKQQIIHGKIPGMVVDRCGCS
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MTAQPLLDVQDLTVEFTTRRGIVKAVQHVNISVAKGETLAIVGESGSGKSVTSYAVMRILDRAGRIAEGSVMFSGIDVKAATEDQMRDLRGREVSMIFQNPRAALNPIRKVGDQIEDVLRTHVQQAQVADHGEKAIEALEQVKIARPRERYHAYPFELSGGMCQRVVIALALACNPQLLIADEPTTGLDVTTQKAVMDLIVELTRRRAMSTILITHDLGLAAAYCDRVVVMEKGRVVETATAADIFANPQHPYTKKLMRATPRLGVSLRDLLPEEEGASFASPRVRGEADARSAGGEGDSPSTVLAETPPHPNPLSASEARRDPASGERGKSEQPLLLIEKLVKEYPRQGATATLGKLFGRKPPVEPDVFRAVDGISFSIGHGESVGLVGESGCGKSTTSMMVMRLLDQTSGLIQFDGEDIGGIAPASFARLPQRSRIQMVFQDPTDSLNPRFTAARAIADPIMQLGDVRGRDALRARCEELATMVGLPHNLLDRFPHQLSGGQKARVGIARAIALHPKLVILDEPTAALDVSVQALVLNLLQDLKARLGMSYLFVSHDLNVVRLLCDRVIVMRTGRIVEEGSSERVLSDPQDDYTKELLTAIPHPPLPVH
The following text describes a protein:
Function:
Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.
Miscellaneous:
MISCELLANEOUS: Knockdown results in multiple defects in neural crest-derived lineages such as cartilage, pigment cells, and enteric neurons.
Sequence:
MFYGSSSASMSLPSKNRLKRQSRTFTQVLYRTLSYRDRRSVTDLPEQVRDDPAELSTQSSAPGVLKIFGDEISAGANYKSVLATPRSSAQELIKEALERYSLNKTSACNFVLCDVIGRFEGPDRRWRTECLRALGNNEKPLLLQDLWKPKEGFSRRFELRRRAEVEELAAKEKDTVTADINAQARKLQRNRAKGTMTLQHGSSFCRSLSETSLNLVGLPGEEPKRYYSTLPGPIRTRSARDSEIRKERDGGGVKHSLYQSPHLLLLQGYNQQDCLVYLLNREQHTVGQETASARPNICLSSPDVLPLHCRIRRAAQRRSSSDQRLLLEPVAHGNVLVNFMRIERPTPIRHGDLLSFGAHYIFLYKDPLSAKPLPAQTLTRLRTLAKLCDGESGGLPEKGDACRMCGAVLHEPAASSRRSSKAPARGSQKRKLALEFERAHEDALVNRVLTLIEPSGDDHKLTPAYLLCLCIKHSANTFPPGSFGKLLQKIAKRIQTIAWEKTKELAQKQAQHQDPASLSLLSISDLVPDLQFIFFWMSNAIEILYFIQQKSPAYMQTIELMDDKAGSKESLLSATISANEEAMTILEEVIMYTFQQCVYYITKTLYVVLPGLLDCNPFGTEPSSEQCRRAAGVCVCAVCVMPEAVRRVVSVFQTTSDLLQQYQVHSEIQSQMFAYLFFFTNVSLFNQLIDKGPARGWFQRSRVLQIQASVKILLDWAKGAGHNHLAQKFFAKFCSTVTILASPPQQLSQMSWKALCAEHPSLKPVQLHRILTQYQLMAELGPLPIWQPSSEDEAYIYRTVDLLESFENHPPIVLPSAGFKVDLESDCVEDSIYRQLLYVRHFVWGLRTKTHPSNGCTDRQDAQREPPQPHSSPHPAPSVRGEGEGEVRSSSTTLGGRGEGAGAEDRTRDKPTHGIHYRNGSGARYANQSQATDSSCILTPPNTPLYPEHTYIQSNTAHYPEHASQEHTHTHSHTKTNGCMRSTPEHKKINGFISNGIEGPLSGCGFPFPVPVSHLGPKSDDICSVFVVDLDKGPYGLGMGLIDGLHTPLNSPGIYIRTLIPDGPAAADGRLCIGDRILAVNGTSLIGADYQSAVDLIRLGGGRLRFLVAKSDLEVSEKISASSC
The following text describes a protein:
Function:
Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. May function as a nitrate/H(+) and nitrite/H(+) channel. Could confer a selective advantage during severe nutrient starvation or slow growth.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MALQNEKNSRYLLRDWKPENPAFWENKGKHIARRNLWISVSCLLLAFCVWMLFSAVTVNLNKIGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCVWLGIAVQNPNTPFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQGSALGINGGLGNLGVSVMQLVAPLVIFVPVFAFLGVNGVPQADGSVMSLANAAWIWVPLLAIATIAAWSGMNDIASSRASIADQLPVLQRLHLWLLSLLYLATFGSFIGFSAGFAMLAKTQFPDVNILRLAFFGPFIGAIARSVGGAISDKFGGVRVTLINFIFMAIFSALLFLTLPGTGSGNFIAFYAVFMGLFLTAGLGSGSTFQMIAVIFRQITIYRVKMKGGSDEQAHKEAVTETAAALGFISAIGAVGGFFIPQAFGMSLNMTGSPVGAMKVFLIFYIVCVLLTWLVYGRRKFSQK
The following text describes a protein:
Function:
Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior.
Subcellular Localization:
Cytoplasm. Apicolateral cell membrane; Peripheral membrane protein. Cell junction, septate junction. Note=Localized to epithelial septate junction at the boundary of the apical and basolateral cell surfaces.
Sequence:
MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDAQQPTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAHQQQQQTQLAPLGQEKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAEEQQEEVRAKPTPTKVPKSVSDKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEKLRQEEERKIATLRRDKNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVDNAALGHFDDAEDMRNPLDEIEAVFRS
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MLIFIISIIITIASIIFLFETVFNKNSNTINNNNNSNNNNNNNNNNNNNNNNNKNNIKENNIDKNKEIKIKEKLILNNNDPKENDLKYKEEFNNFLNKFSKNQEYGYKDNLIDNELRNHYNNNNNNNNNNNNNNKDDQFPKLKDIVYLDHAASTLASMNQIEEISKELKNSMFCNPHSVNPIGLKTKEEVDSIRENILNYFNAPYRQYSVIFTSGCTDSLKKVGEYFAWTKNSKFYYSLESHNSLLGIREYACESIGGSSTTSFQPIPSLYFKCNNNQFNDILEIIGNNDDNNNESYSLFGYPGQCNYSGTKYPLELINRIQKKYPKCKVLLDAASLVSTSSFDLTKYPVDFMTISFYKMFGYPTGIGALIVKNDSGEKCLINKKYFSGGTVNVSMAQERFHVDRPSLSERLEDGTINFMNIISLKHGFNIINNQLGGIDNVKLHTFSLTQYCKEEMLKLYHSDNSKQQQLCIIYSDNHFKDSSKQGSIINFNIFRSNGELFGYNQVEKLASLSSIYLRTGCFCNPGACHGYLNLSKKDIEQHLKDGHVCWDSKDILNGKPTGSVRISFGYMNNFNDVYKFINFLKSNFINDHKFEKEVIKSNKKINNNLCDISDNISCSGSCGGSCGSSGSGIEDYQVQYSNNIKEEKEEEEKEEIENLKNEKDNDEVLLSEIYIYPVKSCSGHKVVNDKWELVPSGLKYDREWTIIDQSGNYINQKKLPILALIQTEIDLINDKLILTAPEMKVLSIPLSYYPISAFDQIQVCGDKVDGLLYGDKDFSNTSGSSAGSGGGGGGNIDNISEWLYQFIGKRCYLVRKSPESHRKSKVDSSNEISFANESPYLLINEESVSDLKKRIIKDNPDSVPSDWNWISKHSFRANFIITGGKAYQEDLWSQFQLISKQQNDTTQSSSSPLVFNSVGDCNRCKMICINQKMGIEEREPLSTLASYRRSGGKIIFGQHLNFADSIKRNNSHTNDTALSSNESSISSSNPIFLHVPSKLKVLSERY
The following text describes a protein:
Function:
Involved in pyrimidine catabolism. May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously (Probable).
Miscellaneous:
MISCELLANEOUS: The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function).
Sequence:
MKLSLSPPPYADAPVVVLISGLGGSGSYWLPQLAVLEQEYQVVCYDQRGTGNNPDTLAEDYSIAQMAAELHQALVAAGIEHYAVVGHALGALVGMQLALDYPASVTVLISVNGWLRINAHTRRCFQVRERLLYSGGAQAWVEAQPLFLYPADWMAARAPRLEAEDALALAHFQGKNNLLRRLNALKRADFSHHADRIRCPVQIICASDDLLVPTACSSELHAALPDSQKMVMPYGGHACNVTDPETFNALLLNGLASLLHHREAAL
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDAVSECSVASTLAVEVSTACWRRRSPGEASTWCLKASQPHPKLSQHPQHSGSDKTQQQGRSPVCPVGPGKRSSPVISTPRTPFQAVGPLLVRRVRMATGNCRFSEHSNRGLCSAHPCGTLLIAAAQ
The following text describes a protein:
Function:
May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG). In fact, is not able to exhibit diacylglycerol kinase activity in vitro.
Sequence:
MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPGHAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRGFSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAMEFPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFYGGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITFYTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKIGVIMGGISTEREVSLNSGREVIKYLELLEHEIIPIIIDKKEDVMEKAKGIDFAFLALHGKFGEDGTVQSVLQTLDIPYSGCGPLTSAICMDKDMTKKILKYANINTADWVNVSSVENIDYEAIEKIGYPVFVKPNSGGSSVATNLVKDKEGIKEAVELALKYDKEVMIENYTKGEEITCCMLNGKMLPVLAIRPHAEFFDYTAKYADGGSDEVVIELEENLHKKVEEMALACWKELKCEVYVRVDMIVKDGIPYVLELNTLPGMTKNSLFPKSANAVGISFAELLNSIVKYSLEVER
The following text describes a protein:
Function:
Fungal class D1 G-protein-coupled receptor that acts as an alpha-factor pheromone receptor performing pheromone-dependent signal transduction involved in cellular conjugation, mating projection assembly, and in cell fusion. Following alpha-factor-binding, the signal is transmitted via a tripartite G protein consisting of alpha-, beta- and gamma-subunits (GAP1, STE4 and STE8 respectively) that prepares the cell for conjugation. In the inactive state, the cytoplasmic end of transmembrane domain 7 (TMD7) is unstructured and packs between TMD1-6, blocking the G protein coupling site. Agonist binding results in the outward movement of the extracellular ends of TMD6 and TMD7 by 6 Angstroms. On the intracellular surface, the G protein coupling site is formed by a 20 Angstroms outward movement of the unstructured region in TMD7 that unblocks the site, and a 12 Angstroms inward movement of TMD6.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Internalized after binding of alpha-factor. STE2 enters the cell by receptor-mediated endocytosis and is continuously lost and resynthesized in the presence of alpha-factor.
Domain:
The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate homooligomerization. The highly conserved sequence IXXGXXXGA (residues 53-61) is a glycine zipper motif in which shallow grooves in the alpha-helices interact with one another; The transmembrane domain 1 (TMD1) and TMD2 mediate oligomerization by providing a homophilic interaction surface that stabilizes dimers/oligomers; The third intracellular loop (residues 231-243) is essential for signal transduction; The DAKSS motif (residues 335-339) is required for internalization of STE2 in response to alpha-factor-binding; The region from residue 251 to 294 which encompasses transmembrane domain 6 (TMD6), the extracellular loop between TMD6 and TMD7, and TMD7, is involved in the binding of alpha-factor. Polar residues in TMD6 such as Gln-253 or Ser-254 influence receptor structure by forming intramolecular contacts between TMD6 and the neighbor TMDs; The C-terminal cytoplasmic domain is highly phosphorylated and involved in regulation of the pheromone response via promoting the formation of receptor-G-protein preactivation complexes. This domain is in particular involved in the interaction with the G-alpha subunit GPA1; STE2 has an extensive orthosteric binding pocket that involves residues throughout the extracellular half of the receptor.
Sequence:
MSDAAPSLSNLFYDPTYNPGQSTINYTSIYGNGSTITFDELQGLVNSTVTQAIMFGVRCGAAALTLIVMWMTSRSRKTPIFIINQVSLFLIILHSALYFKYLLSNYSSVTYALTGFPQFISRGDVHVYGATNIIQVLLVASIETSLVFQIKVIFTGDNFKRIGLMLTSISFTLGIATVTMYFVSAVKGMIVTYNDVSATQDKYFNASTILLASSINFMSFVLVVKLILAIRSRRFLGLKQFDSFHILLIMSCQSLLVPSIIFILAYSLKPNQGTDVLTTVATLLAVLSLPLSSMWATAANNASKTNTITSDFTTSTDRFYPGTLSSFQTDSINNDAKSSLRSRLYDLYPRRKETTSDKHSERTFVSETADDIEKNQFYQLPTPTSSKNTRIGPFADASYKEGEVEPVDMYTPDTAADEEARKFWTEDNNNL
The following text describes a protein:
Function:
Membrane-anchoring mono-heme cytochrome b subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH3 and SDH4 form the membrane dimer that anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSAMMVKLGLNKSALLLKPSAFSRAAALSSSRRLLFNTARTNFLSTSPLKNVASEMNTKAAIAEEQILNKQRAKRPISPHLTIYQPQLTWYLSSLHRISLVLMGLGFYLFTILFGVSGLLGLGLTTEKVSNWYHQKFSKITEWSIKGSFAYLFAIHYGGAIRHLIWDTAKELTLKGVYRTGYALIGFTAVLGTYLLTL
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MATTTPSWEPALAAMEDAVTTLEERMDALAQRSPAELREKLSPLDQCKLDLLLAYNANSLFWMFLSSRGVDPAKHPVRAELGRVRDYMMKIKGLERDPSAARSNLNKEAAERFVRHALDDGNDQANDGSPSTKKSRTATNATTPDSDRKKAKKDKKDKREKKDKRDKRKSK
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MAGLLYPLSGGAVGLDSSLSMLEATIPREALPVERPRANGKEEEEENDENLPMVFLCGGCKRPVGDTLSWVANDEETECILLRSASSNVSVDKEQKLSKRPGECGCMVETFFCSGCSMTLGSIYRCTPKHLDYKRDLFCFSVGAIESYILGSSEKQAVTDEEPLTLESRAALEEALKRANTILNALEARLATVESRIDSLHSNA
The following text describes a protein:
Function:
Regulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion. Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P).
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MNKTNWKVSVTTFNCGKEFPVENSKAIVKQLLFPYDDGISQLELQDLYVLGFQEVVPIWQGSFPAVNRDLIDRITTTAVNCLNEKVSATQGDEQYSCLGVNSLGAITIIVLYNNNALKVKDDILKRNGKCGWFGTHLKGGTLISFQMTRNGEENWERFSYICAHLNANEGVNNRNQRIDDYKRIMSEVCDSEVAKSDHFFFLGDLNFRVTSTYDPTTNYSSTTTLRRLLENHEELNLLRKGEDEPLCKGFQELKITFPPTYKFKLFEKETYNTKRIPSWCDRILYKSYAVPTFAQEGTYHSVPRSNALLFSDHQPVNLTVRLPRSTGTPVPLSLHIEKYPLSWSSGLIGQIGDAVIGYCGWLVTKNVHYWILGSLLLYLLLKIL
The following text describes a protein:
Function:
[CLE19p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance.
Subcellular Localization:
[CLE19p]: Secreted, extracellular space.
Sequence:
MKIKGLMILASSLLILAFIHQSESASMRSLLMNNGSYEEEEQVLKYDSMGTIANSSALDSKRVIPTGPNPLHNR