lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Macrophage receptor for apoptotic cells. Up-regulates Bfc, which in turn leads to self-up-regulation by Bfc in a positive feedback mechanism in response to detection of apoptotic cells.
Miscellaneous:
MISCELLANEOUS: 'Croquemort' means literally 'the one who bites dead persons' in French and is colloquial for undertaker.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCCKCCGETQRKVWVFGLGSVFLLLGILIVVFWPGIADNLVEDGLTLKPGTDAYESWLEAPIPIYLSFYMFNWTNPEDIRNPDIKPNFVEMGPYTFLEKHKKENYTFYDNATVAYYERRTWFFDPERSNGTLDDMVTAAHAITATVADEMRDQRKIVKKIINFMLNHEGGKLYVTKPVGEWIFEGYQDNITDFLNLFNTTKIDIPYKRFGWLADRNESLTYDGLFTIHTGTDDISNLGRLTHWNGKSETGFYEMPCGIVNGTTGDMFPPKMNVNDEITIFATDACRFMNLRPRGTYENHGLTATKWVGTEETLDSGENYPNQACFCDEARFDECPKTGVVECKACRDKAPIYSSFPHFYLADQSYVDAVSGMKPEKEKHEFFLAVEPITGVPVQVHGRIQINMMIEPDDDFDIYRGVQKVLMPMFWFDQYAELSSELASKAKLAINLSSYGIIFGYSMIAFASVFLITGITLTVTKKWVRRTPEDEDILTN
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
NCNLSKHHYRSSCPQALSIVQAGVKAAVKNETRTAASLLRLHFYDCFGCDGSLMLDDTASFISEKPQACPGVVSWADILAIATRDSVVDLGGPSWKVRLERRDSTTVSRTAANTSIRRPTSNLSALISNFMGSLIEAHGAHTIGLARCTTFREHIYNGWNIGISFTESLRQICPASGNGILHSGQELFNGNSANSLVKRYADDISVFVKDFPRATIKMGNISPLTGSAGQIRINCRKVN
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MNFPLNSKPFLIDSPCLLLAAIFLLSFLYLTKPRTFFLRIFDLGFLLMAEPSPIIETLDEDESPPQIQTLDESPSDDSSNEIGSRNRRPRRNMRYFDYSSDDDDDLSNGIFRNRSAVYGDLYNRRPRRYMQSFDYSSDDDVEMELPKPIDIFSCSSPENKPTGVGAGLNNSGNTCFIASVLQCLTHTVPLLHSLRSYKYHCPCNCGNESFCVLRTLRYHIEHALRSSGCDIMIDRFRDNLNYFSSDFQINHQEDAHEFLQSFLDKLEKCCLDRSRRDNPPSVSSQDVNIVDNIFGGRLVSKLRCCNCNSVSETFETSPGWSLEIEDVEDLSSALESFTCVENLEDQFTCDDCKEKVSKEKQLKFDKLPLVATFHLKRFKNNGVYMQKINKDVKFPLELDLLPYMSSNENPEVSTKYHLYAMVEHLGSGTYFGHYSAYVRSAPETWHHFDDEKVRRISEECVLSKSAYMLFYAREGTPCFASAFEELKTLFDATPMNFSPKSCVSDLSYQTVSDSSNACNGSVGVSIPCGNSSDYHCDEAQDEVFHSAESNSGDEYFAFKSPKADDSEKPFAATFHQEERPLYSDGNRATTDDAYVPVVKIQEQVSSPKREAAERAIVGEETFLTKRKMRKRNPFSKRQGKTFQIRHEHLQNKKKREETCITNPFRSIVAAASDPKEKKHAVSYLRSRPCSSRSRLLVAALGVNVKKKKVSNIRRSSLHRNL
The following text describes a protein:
Function:
Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.
Subcellular Localization:
Virion. Host nucleus.
Sequence:
MERNHWNEKSSGAKRSRERDLTLSTIRSILAADERLRIKASSYLGVGRGVDDEAVIDIFPTGQTMSFLRLLHGFLGTCRGQSMHQVLRDPCVLRKQLLYGVCKTLFDTITVRRVAEEWKLHAALFPYRALDEEDLEQYLLVWSASLRQSVQTGVLGALRDILYQYADNDDYGLYVDWCVTVGLVPLLDVKTKPSEAAERAQFVRAAVQRATETHPLAQDLLQANLALLLQVAERLGAVRIANAPEVRVFKKVRSERLEAQLRGKHIRLYVAAEPLAYERDKLLFTTPVAHLHEEILRYDGLCRHQKICQLLNTFPVKVVTASRHELNCKKLVEMMEQHDRGSDAKKSIMKFLLNVSDSKSRIGIEDSVESFLQDLTPSLVDQNRLLPARGPGGPGVVGPGGAVVGGPAGHVGLLPPPPGPAAPERDIRDLFKKQVIKCLEEQIQSQVDEIQDLRTLNQTWENRVRELRDLLTRYASRREDSMSLGARDAELYHLPVLEAVRKARDAAPFRPLAVEDNRLVANSFFSQFVPGTESLERFLTQLWENEYFRTFRLRRLVTHQGAEEAIVYSNYTVERVTLPYLCHILALGTLDPVPEAYLQLSFGEIVAAAYDDSKFCRYVELICSREKARRRQMSREAAGGVPERGTASSGGPGTLERSAPRRLITADEERRGPERVGRFRNGGPDDPRRAGGPYGFH
The following text describes a protein:
Function:
D-mannose/D-glucose-binding lectin. Binds N-linked high-mannose-type glycans. Has a preference for smaller (Man(2)-Man(6)) high-mannose-type glycans to larger (Man(7)-Man(9)) ones. Recognizes both alpha1-6 extended and alpha1-3 extended monoantennary glycans. The addition of alpha1-2Man to the Man-alpha1-3Man-beta branch results in a significant loss of affinity, but beta1-2GlcNAc has some affinity. Has less affinity for biantennary glycans, and affinity is very weak for the biantennary complex-type N-glycans with bisecting GlcNAc. No affinity is observed for tri- and tetra-antennary glycans. Has mitogenic and hemagglutinating activities.
Sequence:
MEEFLTVGLWGGEGGDRWSFVVNNGGIIGMEIVHANGIASITFKCGDEYGVLQHSRKFGGTGEGWKTDKISLNWPEEYLTSISGTVADLWQHIIIRSISFKTNKGTEYGPYGVVTGQPFSYSTEGGVIVGFHGRSGTLLDAIGAYVKIPQKKDNTLKMALPVPRGPGPWGGHGGMEWDDGVFPAIRELHLYVGDSVIHAIRVSYQSKDGEPLLSPKHGGEGGEPIDPIKLEVSKEFLIRIAGFYGPVEGSGSFKALRSITFYTNKAKYGPYGDEIGQAFTSSVAPGRVVGFHGRSGAYLDAIGVHMEYF
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MSISLFIGRAASSTPIGASCKRINETSANFSLTEFADWDAYATFNDSLNESGWGRLNIRANPKSSSKDQMFCMGYIDTAISASRVYEAYKLYREENNAKDAWPKGWENWINQNIEYINKQIQVNPQDPYWIGISLIREQFRGMVNGLREHRPEGEAEIKEVDFWIFQSAGDFEDIDQALNPEKIRRAEPELHAHCTGLLKFAPDYSDIYFAQDTWSDVRELHAYLKSYSFEVKEFKAKNIAISTRTGHLSSVDDFWMADTNLLVLETTLHCFNQTLYRIGVTPNSVLTWMRVYYAMLKSDNGKDWTQNFIFENSGTYNNEYIVLDGNKFTPGQKPVSDLVWMIEQLPTTFHAEDITDKFVEQGWFPSINTPYFEDIFNLADYPGQQQRQPAKKDFWSYYEQPRYKVIVKHVKDNTTYSFFQQLMRWNKYTDPSEPNYGEPAQGILARYDLRPDNGTAFGSKASFAGLDSKTASLKQAMKHFTFDAIASPQYENLPAFSFSNWPGISNYGLVDTWKFPWTTFGASEKTCATFNNSKDCLDMPGCGYCMHTDKCLPALSKDRPAFGCECEDGWKVKIYLLPFAIPMIITCSSLIVVFLIAVYVMAYFYAKKKAAANPNYDSIK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSNIIQLLTGEVAIRTHHVSIYFSLDEWDYIKGNKDLYEEGMKEEPQQLRPLDSEYEEIGDNLQVMLRCEIQPNKIGAQEGDANLTNLDISPTEQPSPTNGIKKEVASSEEGNQSDCSINPLTEQIQGTDTHTPMMELILNNSLSNNYILNDIKQQPYSQEGGNQSDCSINPFIESIEKVDMPTPTLELGLYNSLPGNYISNGIKEAFWEGGNQSDCSIYPLLEQIQGTDTQTPIMEYSLNNSLADIFLLNSIKGKKTSWEGGNQSDCSINPLTEQETDTHTPIMGYSLTNDFYETNLMRISKNSPSQGSHPLQVRYDCTGYHRTYCTKRLLTKHQNTGKEEKPFTCSQCGKRFTHLCDLKRHLKIHLGVKPHSCSECGKRFTHRSHLVVHQRTHTGERPFVCSECGKSFADHSALNVHHRIHTGTKPYGCSECQKRFTHRSQLSAHQRVHTGERTHSCSECGKWFSRTAHLRRHQKTHTGEKPYFCSECGKSFMHGSDLKRHQNIHTGVKPFLCSECGKCFTYRTQLTVHQKTHQSLSIQSIPFCNVAIRTHHVSIYFSLDEWDYIKGNKDLYEEVMKEEPQQVRPLDCEYEEQSDIKAIQDVTIFCINEPSKSVAEGGDYCEGVSVTNADISPVKQPPPASGIEDELEGGNHSGLSLSDDYISVVVKEEEVTSCEEGNQSDCSISPLTGKIQGTDTPTPIMGWDIHKDFLEAECRENCENIEKCEFLSKRRRHELPLLYNINSFAENHRINTGQKPHSCSECGKCFTRRSNLKTHQKTHTGEKPFSYSECGESFIHRSDFAEHQRTHTGEKLHSCSECGRCFVRPSELNVHQRIHTGEKPYSCSECRKRFTHRSDLTQHQRIHTGEKPYFCSDCGKCFTQHSHLNVHKKIHSGEKSFSCCECGRCFTHLSRLKIHQKIHSGEKPYSCPECGKCFTQRFNFREHQKIHRGEKPFSCAECGKCFTQRSNLNVHRRTHTGEKPFLCFQCGKCYTSLKNLSHHQRIHSH
The following text describes a protein:
Function:
Has a role in pre-mRNA splicing where it is involved in spliceosome assembly.
Subcellular Localization:
Nucleus.
Sequence:
MSNAPSNTPTGFNYKPGHTLYIRNFGTDMRARTLGQAFEKWGRIVRCDIPISSNPQAHRYAFVEFEEREKAELAHEKMRNAKIGNDIIFVEWAKSRERYHRDDKRRLSNYA
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MKALDKIREIVNKFSFNIREAQEIICHVLKIDKIQLYTENPEITSEQAHTIKSLIERRLKKEPLQYIIGECYFYNIKIKVGRGVLIPRPETEILVEQVLERQKLISNTGNRILDLCTGSGCIALAIGKNAPEFQIFGIDKSEKAVKYATENKALNNIKNVIFLVGDMFNPFKEKIFACITANPPYVKTDEISKLQPEIKNYEPLEALNGGEDGLNFYRKIIENAEKYLLNSGLIFLEIGQGQAKAVQNIALMSGFNVIEVVKDIAGIDRVMILQKSKSL
The following text describes a protein:
Function:
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVWWGSSLLLPTLFLASHVGASVDLTLLANLRITDPQRFFLTCVSGEAGAGRSSDPPLLLEKDDRIVRTFPPGQPLYLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSAHVHKEKQTDVIWKNNGSYFNTLDWQEADDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILSMATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRKPDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSENVTLMNLKPKTGYNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLESWHVEGPDRLRVSWSLPSVPLSGDGFLLRLWDGARGQERRENISFPQARTALLTGLTPGTHYQLDVRLYHCTLLGPASPPAHVHLPPSGPPAPRHLHAQALSDSEIQLMWQHPEAPSGPISKYIVEIQVAGGSGDPQWMDVDRPEETSIIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGLQSEGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
The following text describes a protein:
Function:
Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MGPGGPVRSWGGEGGSRLRVRCPQRCSWRRCGRARARAAPLRRAGRPTRSAASKPPNAASATDPTPATTPAPLCPGVRTRGTLPPQTPALCSPLFSPSPYYPSWGGSLPGLVCSDFPYTYWFPFFCQFAPSRCVGHFYYAKVRLGARGGWRQECVGNEGLRYPSPSLSPSWAKGLSISIKELLQSSLSLEGPDLSRPNGISPGPLDKAPPGPKAQAKAPALPRPSPEAGAKAPSGPGPGAVREVRGLSMPRDGPDGPFLPHRGGCPSLAFRLFAVPGSWHYPRDGCGGWSGSRAAGPSVWTEGVSHGGPLPLPSLQTLPHDAALLVLCFALLRDSCTRSPAAWAWQRIENETLGFGDTVCDSHGRRHLSSCPLCAFCSLKLEQCQEESTLKREFCGPSHQTPFSSPFLASGGGLTKGLYYGLEVFGGLRMAFWCGRLAVQGCEETRVSGWLQAEFLSFQRGDFPTKICDSNKVEYPNYCAFKSRQCLLYSRDSQKVRPPPPTPNPPHRNHAPFSPWVGGGAETPSRLLIGWANPRVGAAPMVGVTCTQNPPPSPAQVFRQSCQRNESYSQLSEASAEEAVLSWSREFGRLTQG
The following text describes a protein:
Function:
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MSIPAHLQILQPSELEALKKLQDELPKILEKTDYNEMYGHKLSEAEDGPGKAYSEVKRDIILLKFLKARDYDIAQTKDMLTDALKWRKEFDPLDCASAKHDSKFDKLGVITDKGAGGEPQVTNWNLYGAVSNRKEIFGDLKGFLRWRVGIMERSLALLDFTKPGAGSMLLQIHDYKNVSFLRLDAETKAASKETIRVFQSYYPETLERKFFVNVPTLMQFVFGFVNKFLSRETVAKFVVYSNGKDLHKSLGSWVPAEYGGKGGPLLEMAISDHPVQEAETKETKEKEKETEKPVGTSETDTVGDAAEPAPTEPAAETVPTTEPAPTEPAAETAPTESSTAPSAEPAAETAEPVSEGAKVAAQ
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alpha-lysine and L-beta-lysine.
Sequence:
MNTVNTRKKFFPNVTDEEWNDWTWQVKNRLESVEDLKKYVDLSEEETEGVVRTLETLRMAITPYYFSLIDLNSDRCPIRKQAIPTIQEIHQSDADLLDPLHEDEDSPVPGLTHRYPDRVLLLITDMCSMYCRHCTRRRFAGSSDDAMPMDRIDKAIEYIAKTPQVRDVLLSGGDALLVSDKKLESIIQKLRAIPHVEIIRIGSRTPVVLPQRITPELCNMLKKYHPIWLNTHFNHPQEVTPEAKKACEMLADAGVPLGNQTVLLRGINDSVPVMKRLVHDLVMMRVRPYYIYQCDLSMGLEHFRTPVSKGIEIIEGLRGHTSGYAVPTFVVDAPGGGGKTPVMPQYVISQSPHRVVLRNFEGVITTYTEPENYTHEPCYDEEKFEKMYEISGVYMLDEGLKMSLEPSHLARHERNKKRAEAEGKK
The following text describes a protein:
Function:
Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Subcellular Localization:
Cytoplasm. Note=Just below the plasma membrane.
Sequence:
MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH
The following text describes a protein:
Function:
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MAFSKGYRIFHKLDPTPFSVIVEARNREECLLFESGAVAVLSSAEKEAIKNSYTKVMDAYGLLGVLRLNLGDSMSYYLVLVTGCMSVGKIQDSEVFRVTSTDFISLRMDPMAEDRMSEVRKVLNSGSFYFAWSSTGVSLDLSLNAHRSTQEHRTDNRFFWNQSLHLHLKHYGVNCDEWLLRLMCGGVEIRTIYAGHQQAKACIISRLSCERAGTRFNVRGTNDYGQAANFVETEQVIYLDDCVSSFIQIRGSIPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFLTLKRLYGKQFIVNLLGSKEGESMLSRAFQNHLKASEHSASIQMMNFDYHQMVRGGKAEKLHSVLKPKVNTFLEECGFFFLDKNGVHRTQIGTIRSNCLDCLDRTNSVQAFLGLEMLLKQLEVLGLAEKPQLVTRFQEVFRSMWSTNGDSISKIYAGTGALEGKAKGGKLKDGARSVTRTIQNNFFDGSKQEAIDVLLLGNTLNSDLADKARALLTTGSLHVSELMLQSASPRVLRCMCENYYRYAKPRKIRICVGTWNVNGGKQFRSIAYKNSTLTDWLLDAPRIAGIQEFQDRRSKPVDIFAIGFEEMVELNAGNIVNASTANQKLWATELQKTVSRDHKYVLLASEQLVGVCLYIFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDYNEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKEMIRNQNWDSLILGDQLINQKNSGQVFRGFQEGKINFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNSSLQEGKNIPYTWNPGTLLHYGRVELKTSDHRPIVSLIDIDIFETDAEERQKIYKEVVASQGPPDGTIMVSIESSSPEGNYFDDNLIDELLQQFAAYGEVILIRFVDDKMWVTFLEGGSALAVLSLNGSQVQGKAIHIQMKNPDWMVELEEQINLEKISLSLPSSTSSTLLGEDSEISADYDMEGDVDDYSAEVEEILPQHLQPSSCSTLGSSPSSSPRSSPCPSPTMPEGPPPSLPVRPSRAPQKTPGPPVSSSQAEFQPVVQQNASLTSEPKRPPPPRPGVPPARPAPPQRPPPPSGARSPAPVRKEVGGPGAPPSPGVARRDVEVRGQTPSQMGPPAIAPCSSVRPTIPPRAGVISAPQSHVRPVPARTTPEVPNKPTEPARGVPLLPEPLKPQPAAPLQTSPNSQPPCQKLPEPILPTAVQAASQTPPLQQNLDPPPLPPPRSRSSQNLPTDQNASQQLPANGVVGFKSQFDNDPFVDFSFDQLPNSKLQAPVPISSSSQKESFKLPSAVHNNPSGITCMATLPPVPARTGFQDSTRISPNPFVNRVNTISPTNPFTERSSNAGNPFTVPEMAAHNPLQTRTLDQFSSTSEPELLHSKPTFTLGPMEKSLSLPNKSYSFNDASQKGWITFDDDNGTGKINRHSGNSSTVDHVSSENDLFQLGFTNDWSVTSTASSHTLPLRKPPAIPSRTKREQPSTNVPPNNSPTLEFTDR
The following text describes a protein:
Function:
Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the trans-acting small interfering RNAs (ta-siRNAs) biogenesis by binding and assisting DICER-LIKE 4 (DCL4). Required for DCL4 activity. Required for the 21 nucleotide ta-siRNAs production of the TAS3 transcript in leaves but not in flowers. Plays an important role in silencing RNA of both DNA and RNA viruses. Involved with argonaute 7 (AGO7) and RDR6 in turnip crinkle virus (TCV) silencing. May not be directly involved in viral siRNA production. May stabilize the 21 nucleotide viral siRNAs and deliver them to the RISC complex. Targeted by the viral silencing suppressor (VSR) transactivator/viroplasmin (TAV) protein of the cauliflower mosaic virus (CaMV) that inactivates DRB4 function in RNA silencing. Probably not involved in the guide strand selection from RNA duplexes. Involved in leaf morphology through its function in ta-siRNA-mediated silencing.
Subcellular Localization:
Nucleus.
Sequence:
MDHVYKGQLQAYALQHNLELPVYANEREGPPHAPRFRCNVTFCGQTFQSSEFFPTLKSAEHAAAKIAVASLTPQSPEGIDVAYKNLLQEIAQKESSLLPFYATATSGPSHAPTFTSTVEFAGKVFSGEEAKTKKLAEMSAAKVAFMSIKNGNSNQTGSPTLPSERQEDVNSNVKSSPQEIHSQPSSKVVMTPDTPSKGIKVNEDEFPDLHDAPASNAKEINVALNEPENPTNDGTLSALTTDGMKMNIASSSLPIPHNPTNVITLNAPAANGIKRNIAACSSWMPQNPTNDGSETSSCVVDESEKKKLIMGTGHLSIPTGQHVVCRPWNPEITLPQDAEMLFRDDKFIAYRLVKP
The following text describes a protein:
Function:
Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization (By similarity).
Subcellular Localization:
Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane.
Sequence:
MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKHRRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQIQTVKT
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSRIFSSALQAVFKPSAFLPKTATRSFSILPSLRPATLSSTPSTIFRAPNAITAPSASPSATTGIDGEVLDLLSASSLISSHPALSGLGSQIRCGPRPTMSGATRLVQKRRHGFLSRVKTKNGQKTLKRRLAKGRLRLSA
The following text describes a protein:
Function:
Mono-ADP-ribosylates eukaryotic muscle and non-muscle actin on 'Arg-177'. ADP-ribosylates all actins tested, has more activity on nonmuscle beta/gamma-actin than on muscle alpha-actin. Prefers monomeric G-actin but can weakly ADP-ribosylate F-actin. ADP-ribosylation prevents the polymerization of G-actin to F-actin, causing actin filament depolymerization, destruction of the cytoskeleton and cytotoxicity. Does not possess NAD(+)-glycohydrolase activity, unlike most mART enzymes.
Miscellaneous:
MISCELLANEOUS: In Salmonella spp. the spv gene cluster is encoded on a highly transmissible plasmid.
Subcellular Localization:
Secreted. Note=Secreted via the type III secretion system 2 (SPI-2 T3SS).
Sequence:
MLILNGFSSATLALITPPFLPKGGKALSQSGPDGLASITLPLPISAERGFAPALALPYSSGGGNGPFGVGWSCATMSIARRTSHGVPQYNDSDEFLGPDGEVLVQTLSTGDAPNPVTCFAYGDVSFPQSYTVTRYQPRTESSFYRLEYWVGNSNGDDFWLLHDSNGILHLLGKTAAARLSDPQAASHTAQWLVEESVTPAGEHIYYSYLAENGDNVDLNGNEAGRDRSAMRYLSKVQYGNATPAADLYLWTSATPAVQWLFTLVFDYGERGVDPQVPPAFTAQNSWLARQDPFSLYNYGFEIRLLRLCRQVLMFHHFPDELGEADTLVSRLLLEYDENPIRTQLCAARTLAYEGDGYRRAPVNNMMPPPPPPPMMGGNSSRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPALSDVLKEYTTIVNIIIDKAFMSTSPDKAWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQLSKLRLSDDATADTNRIKRIINMRVLNS
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
AQGSDAVIRGSGTITCVDINQIECGNSSNNATACASLEAVTEESTTIKEGNSHLHAAFQSESLSHEKDFCSKMDNHEFRSSFTQQERRFPFHEATSPGKTLSNFAFSASSSNNEPLVYAKSNANGSMDENSPSTPAYDVAENCGYHKYCSCYVVYRNNYSTGCLVTFSCGGIKMSGVPANGDQGTFSFEREIDDIIRIESQHPQRFGTTTVKLLLLSKDAAQAADAYGTGVEQLEFAVEPTWSRKLEEIASMNVKYSALSAMVHNTDVSMDEQSDLLQRRPYFPIFDEAVEDVVYPKGDSDAVSICKRDFDLLQPETFINDTIIDFYIKISDCGYLKNQIPLQEKDRFHFFNSFFFRKLADLDKDPSSASDGRAAFLRVHKWTRRVDIFGKDYIFIPVNFNLHWSLLVICHPGEVAGFKDEDLGKSLRVPCVLHMDSIIGTHAGLKNLVQSYLWEEWKSRQKGTSEDLSSKFLNFRFLPLELPQQENSFDCGLFLLHYLELFLAEAPLNFSPFKINELSKFLNVDWFPPVEASLKLTLIQRLISELLENHSRAISGNCGVLREFFEQGIAGASLLAESSSFDQPSYYRLNGAQQIEDDAKTGEPPGYFPSGDVVFQQIGQSGSVPYPLRGFGTNPSWNPGISMQGEDVGASSDDSDVGIIENCPIGKDLDLCPKEKIDQESPESMENMGSSTDGFAAYSSEMLETSAIKGIGDPERTHDANGNGDLALCQGNPITLMVENGLHQHSEKVEITSSDVQTMDGDVKAESDEKQAVKDYVIAESDEKQTIKVNVIAESDDRPTIEGDVMAESDEKQTLGDNVMAESDEKPRIEDNVMAESNEKPMIEGNVTTESEKPIIQGNVVSESDDKPTYEDNVMAESEEQPPAKRRRVARAQEGEADVTFVV
The following text describes a protein:
Function:
Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MPQDMPPAGGYDAVQYKRNLPPSAFKPKTLLAFGGLIMVYGWYHLFHGIREQRELAREKMWSRIHLIPALQAEEDRDLVRRHLADVQREKELLGDKAVKAYHSDRYVRPTFAITPGKIIKD
The following text describes a protein:
Function:
Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3-GAP and Rab3GAP1, which has both GTPase-activating protein (GAP) activity towards Rab3, and guanine nucleotide exchange factor (GEF) activity towards Rab18 (Probable). As part of the Rab3GAP complex, required for the rapid induction and sustained expression of synaptic homeostasis at the neuromuscular junction (NMJ) (Probable). Also participates in the regulation of autophagy in tissues such as larval fat cells and adult muscles (Probable). The Rab3GAP complex, acts as a GAP for Rab3 by converting active Rab3-GTP to the inactive form Rab3-GDP (By similarity). At the neuromuscular junction (NMJ), forms a presynaptic signaling mechanism with Rab3 that regulates progression of synaptic homeostasis at a late stage of vesicle release (Probable). Within this mechanism Rab3-GTP acts, directly or indirectly, to inhibit the progression of synaptic homeostasis, and Rab3-GAP functions to inactivate this action of Rab3-GTP (Probable). The Rab3GAP complex, acts as a GEF for Rab18 by promoting the conversion of inactive Rab18-GDP to the active form Rab18-GTP (By similarity). Regulates autophagy as part of a Rab3GAP-Rab18 module. Once Rab18 is activated by the GEF Rab3GAP complex, the Rab3GAP-Rab18 module localizes to autophagosomes, and regulates autolysosome formation and maturation together with the Rab18 interacting effector, the PI3K/Vps34 Complex I.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEEIDDNEFYRENFSADSDWEVFNAQLGEILQKWDVSSDSETRNLKSEEIFSCNWKVEREKLDMLRNGIEVEYHQAILEDEELVRAEAKEITCLQRTSCHHDLMSTGNSFGPPIRSSQELHILARIYGLRRFIVLHPVNPTLNYMRSTSEFNFFLSAVAVVSAEVQSLVPIFVQIYDPKWNYYTGVALAPALRTNFRLIGLEKAPPECRFLMGLLTLFREKVPTSYTQAAMISVCTTYALDTMRIRMPMYVPFDHGLSSEDIVVDGEVSHLEVQQFCALPHGYKPESRTEIYLVYTWPELSEHVAFDSEQRSDFVPAKAPLGKIYLSVEASSYLSCCLRDYQSVAEVTRSLESFVGRNFSGTSSGAEAASNPLDRITEHKLTKRRERSFELPSQAGLTKRLPGPMTESELSELLAYLFPDMHPEMALFPYAKKNFTDKFDPMRIKSAVPDSLVCRLSCLLATCHAHLGSVEGMAQVWAAFTRQLRLLWDNSLMVPGISAGFPDTRTCLLHQKLQMLNVCVERRVQREANSKRKSEGMVGKASSEEEEDEDDDEGEFFDCDDLTAGAGSPTKAVLSLKPEGRLRRLNNERLLEEPDEYLYIPDTQEPVPKTEDQLQDDAEVMLKLGPGSGLTTQMMCTSLLSDMEAFKAANPRGIMEDFIRWYSPKDWEEVTDELGQVKHQLSIRMTTEGNTWQKVWEQAQAVPVSRQKRLFDDTNEALKVLHYLETRKMHEIYNLTVIPLLHSAILKLADILSNAELEDLFSSQIEKLLSDLCRLSRSHSDELPSIKPLLDDLAELERRFYQFKCFERLSGYPKRSSLQQVKLQFEEILRNDNCCTIVNRRLTAAGDGTLYDILIPKLEEDMADRLISKDYIIRLDGDTKTTEKGLYLGPQFMRAIVTGEKLRLCGAFTESTAFV
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
Sequence:
PTVSIGNVGQLTIDLLISSLQAPLVGHLSSDCVVPVVGRDAFDLNSNLLTTSLDVHECEKHKLVILQQRSPIIKRRQQRFIDELTKWIKDMKFPHVIVYTSVLACERIDSQLYGPQCRFMSTNNNTHLNMERLAEIFPCLETRQDIVAVADGAAVNQPYIPGSGITKKLLYKFNNENIESVVLLRFSYEADNIPDAVELFNLTNTYFNWIDVSCYFQVPENMKMPPSWSLLFGSHFDQIIYQ