lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional activator involved in gene imprinting. Catalyzes the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism. Allows the expression of the maternal copy of the imprinted MEA gene before fertilization, possibly by antagonizing or suppressing DNA methylation on target promoter. Probably acts by nicking the MEA promoter. Required for stable reproducible patterns of floral and vegetative development.
Miscellaneous:
MISCELLANEOUS: Although strongly related to DNA glycosylase proteins, it differs from these proteins because of its large size and its unique N-terminal basic domain. The DNA repair function has not been proved and may not exist.
Subcellular Localization:
Nucleus.
Domain:
The DEMETER domain, which is present in proteins of the subfamily, is related to the J-domain, but lacks some important conserved residues.
Sequence:
MNSRADPGDRYFRVPLENQTQQEFMGSWIPFTPKKPRSSLMVDERVINQDLNGFPGGEFVDRGFCNTGVDHNGVFDHGAHQGVTNLSMMINSLAGSHAQAWSNSERDLLGRSEVTSPLAPVIRNTTGNVEPVNGNFTSDVGMVNGPFTQSGTSQAGYNEFELDDLLNPDQMPFSFTSLLSGGDSLFKVRQYGPPACNKPLYNLNSPIRREAVGSVCESSFQYVPSTPSLFRTGEKTGFLEQIVTTTGHEIPEPKSDKSMQSIMDSSAVNATEATEQNDGSRQDVLEFDLNKTPQQKPSKRKRKFMPKVVVEGKPKRKPRKPAELPKVVVEGKPKRKPRKAATQEKVKSKETGSAKKKNLKESATKKPANVGDMSNKSPEVTLKSCRKALNFDLENPGDARQGDSESEIVQNSSGANSFSEIRDAIGGTNGSFLDSVSQIDKTNGLGAMNQPLEVSMGNQPDKLSTGAKLARDQQPDLLTRNQQCQFPVATQNTQFPMENQQAWLQMKNQLIGFPFGNQQPRMTIRNQQPCLAMGNQQPMYLIGTPRPALVSGNQQLGGPQGNKRPIFLNHQTCLPAGNQLYGSPTDMHQLVMSTGGQQHGLLIKNQQPGSLIRGQQPCVPLIDQQPATPKGFTHLNQMVATSMSSPGLRPHSQSQVPTTYLHVESVSRILNGTTGTCQRSRAPAYDSLQQDIHQGNKYILSHEISNGNGCKKALPQNSSLPTPIMAKLEEARGSKRQYHRAMGQTEKHDLNLAQQIAQSQDVERHNSSTCVEYLDAAKKTKIQKVVQENLHGMPPEVIEIEDDPTDGARKGKNTASISKGASKGNSSPVKKTAEKEKCIVPKTPAKKGRAGRKKSVPPPAHASEIQLWQPTPPKTPLSRSKPKGKGRKSIQDSGKARGPSGELLCQDSIAEIIYRMQNLYLGDKEREQEQNAMVLYKGDGALVPYESKKRKPRPKVDIDDETTRIWNLLMGKGDEKEGDEEKDKKKEKWWEEERRVFRGRADSFIARMHLVQGDRRFSPWKGSVVDSVIGVFLTQNVSDHLSSSAFMSLAARFPPKLSSSREDERNVRSVVVEDPEGCILNLNEIPSWQEKVQHPSDMEVSGVDSGSKEQLRDCSNSGIERFNFLEKSIQNLEEEVLSSQDSFDPAIFQSCGRVGSCSCSKSDAEFPTTRCETKTVSGTSQSVQTGSPNLSDEICLQGNERPHLYEGSGDVQKQETTNVAQKKPDLEKTMNWKDSVCFGQPRNDTNWQTTPSSSYEQCATRQPHVLDIEDFGMQGEGLGYSWMSISPRVDRVKNKNVPRRFFRQGGSVPREFTGQIIPSTPHELPGMGLSGSSSAVQEHQDDTQHNQQDEMNKASHLQKTFLDLLNSSEECLTRQSSTKQNITDGCLPRDRTAEDVVDPLSNNSSLQNILVESNSSNKEQTAVEYKETNATILREMKGTLADGKKPTSQWDSLRKDVEGNEGRQERNKNNMDSIDYEAIRRASISEISEAIKERGMNNMLAVRIKDFLERIVKDHGGIDLEWLRESPPDKAKDYLLSIRGLGLKSVECVRLLTLHNLAFPVDTNVGRIAVRMGWVPLQPLPESLQLHLLELYPVLESIQKFLWPRLCKLDQRTLYELHYQLITFGKVFCTKSRPNCNACPMRGECRHFASAYASARLALPAPEERSLTSATIPVPPESYPPVAIPMIELPLPLEKSLASGAPSNRENCEPIIEEPASPGQECTEITESDIEDAYYNEDPDEIPTIKLNIEQFGMTLREHMERNMELQEGDMSKALVALHPTTTSIPTPKLKNISRLRTEHQVYELPDSHRLLDGMDKREPDDPSPYLLAIWTPGETANSAQPPEQKCGGKASGKMCFDETCSECNSLREANSQTVRGTLLIPCRTAMRGSFPLNGTYFQVNELFADHESSLKPIDVPRDWIWDLPRRTVYFGTSVTSIFRGLSTEQIQFCFWKGFVCVRGFEQKTRAPRPLMARLHFPASKLKNNKT
The following text describes a protein:
Function:
Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.
Subcellular Localization:
Cell projection, microvillus membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Note=Colocalizes with PTPRH and CEACAM1 at the apical brush border of intestinal cells.
Sequence:
MELAGFHCCSWTVILLSALLPTTWRPPAAAHFIHRADLLSNTQMERAPLAKLTLTVNQSTVTEQREMAVFYCNTNADNITIHWVSNNSLLVLNERMKLSADNKTLTILIVQREDSGSYLCEVQHGFEVQRSNTASLTVNYGPDPVSIKLDSGVAAGDVVEVMEGNTVNFRVEAQSSPVPAYAWYLPSDFIQPPTTGTFTIDAVSREHEGMYRCLVSNPVTNLSRLGVVKVQVLEKVTAPNIEFPTLALVENATSVTLTCKTSHQRVGVHWFLKGQPLRPSDRLTLSSQNRTLTIHGLQRDDIGPYECEVWNWGSQARSVPLKLTINYGPDQVEITQGPASGVVSTIEAMLNSSLTLYCRADSIPGARYQWTHEHSSKVLDGEQLSIEALRQEHQGIYSCTSSNDVTGLARSASVLVMVVGLQSSSMSPGAIAGIVIGILVAIALAIGLGYFLYSTKDRWTRRRSASDTTSSNTIPPTSVMQSTPESRHNKPMTVYDNTPKPEGEARGKKMWSLPRDSPEQFYEKKPPSAAPEGPRKPLPQIPKQPLMPPGPGRNEESNYEKLLNSNHSLYCKITPSA
The following text describes a protein:
Function:
Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Associates with mitotic spindle microtubules, particularly in the vicinity of chromosomes.
Sequence:
MALSSQLQSLDALKYVELQQVAKAAGLRANLRADKLLKALKQHFQGRIQENENTSSEKSASSSMDSELSCQQEFMPNPACFVTKRCKEKKATRKKKSSDMETNDSEENTGPSAEIEGHSETKENEVPQGDCEKEKMVFQNVEQVTKKRANENPSMATAEKKQPKRTSTKSARAKCDPHPVGQKIPLHVGSASKPGKTGLKATTPNFKRLHEAHFKKMESIADYIERKKKMLENCSSSLNEAKRHTSSKTLLFSPNPDRGRFSGTCTPSNLRRSPRGLLNTGSQSILSRKSSFNPSVLSTTKMNVRFSEATKDNEHKRSLTKTPSRMSPYVEEICTPDSQKSCEPLSAKNSKRSTRNNDLPALKAITPFKFAAQSAEPSSTKKVFDLKASLSRPLRYQPHKGRLKPWGELKENAPLKKSVSNSITSHKRDYKQPHLQSREDRREKHEQERKKKKAQALGNRRGLSMG
The following text describes a protein:
Function:
Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted.
Sequence:
MKFIFYLSVLTGTFLFADSSVQKEDPAPYLVYLKSHFNPCVGVLIKPSWVLAPAHCYLPNLEVMLGNFKSRVRDGTEQTINPIQIVRYWNYSDSAPQDDLMLIKLAKPAMLNPKVQPLPLATTNVRPGTVCLLSGLDWSQENSGRHPDLRQNLEAPVMSDKECQKTEQGKSHRNSLCVKFVKVFSRIFGEVAVATVICKDKLQGIEVGHFMGGDVGIYTNVYKYVSWIENTAKDK
The following text describes a protein:
Function:
Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors. Protects the organism from the toxicity of D-amino acids. May also function in the intestine.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MNKRKQRVAVLGAGITGISTATXIQLLCPNTEVTIISAEFSPNTTSDGAAGFVQPYLAPGTPRKDIERWFTSTWKRLAMLINSVDAGKAGVHFTSGYNVFKTVVPDPEWKDKVLGFRHTTQEELKELFPSFKHGWFFTSIICEGQRYIPFMTEKFLKNGGTMIQRMVTVFAEVSGLELIRLLQQNSTIPLTMVQSYYFTMPNLIFFLLTPLQLSGQYDVIVNCTGIGSRFLANDDSVEPVRGQVMKVHAPWILGYNRYRGDPGSGADKHHIYPRQDDVTVGGTAQLGRWDTEVDPEDAKQIWERACKVVPSLKSAKIIKHWVGLRPQRSKGVRVEAETMTYGSDKVKVVHNYGHGGCGITLHWGCAQDAAKLVQKELIHMPASRL
The following text describes a protein:
Function:
Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart development (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDETCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARAKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSDRPGSASEGEGDEIRPYGEDRDSSEESEDDDPEEAKRIAEGFIVDEDEEDGEGEDDEEDEETRRRRRKEEKRRRKKERRMRREREEAELSEDELELIEENRGLREGRPLKRLRRRSGSEGSENDRAVPTLQDMFRDDEDRMEDDDDDLMDFIEEDEEDEANQGETEEQRRERKRAEKLKRREQARSRPELTGVDRSSWDEIFAVFGDGQDYDWALEGEDGMDLDEEEEAAKKDLRLEDVFDPAEIKARRLQDEDKAVANADRPERHQIVNSTLSDNPVFATDTLYPPPDFAAKWVAPKVSFRTQYLFYNQHPEGSYPIPTIDNPQPYPVYRRPDLEIEFEKAVSTALNMMFVQHLEVPYLWHYKRDVFSLLENQGQSSVLFLERDELWQVYVLGQRYRAIHERNEQTRQQWGKIKARKGDIEDEYFTKGLLGKACVASIEAAGEGDEWLAYHYASDIKAIKEEEAFDEVSKKLPERAEREDIRRGRIMKLVEAFGIDANKVASSFQDVHGQPAPVMNPDKMPLELADEFTGAAYSSPEQALSAASFVLVQELSKDPAIRQQARDFMDTCGLVTVNATDRGMSVIDQYHLYYNFKFLTNKPVLDFRDSPQFVHMLKAEEEGLINIAFDIREDMLASFTDALIRCCRSNDYGEIASAWNEVRMEVCNTLVKKHLMPMASKWIKEHLRTQAEEYIAERCREELELRVNVRPYASSGMEQGETPSVLAITNGKGDIRDAVMAVMLDDEGNVRTQTKFDNLRDEEDKTMFIELLEKRKPKVVVIGGFSAQTARLKDAALVAIRQHAIELLGQNPPVSDAYPDHEGFQYAMAEYDEKLKAHLIPLIFVNDATARLYMSSEEAEKEHPNLPLNGRYALGLARYAQNPLNAYCKLGKHIASVTFMEHHQKLIPQEKLLYHLERGLVNSVCFMGIEINSCVADPYQRAMLPYIAGLGPRKADAVIYGIQKHGALINRMAFTDLGLFGPTIFENTAGFLTIESDLKDMMLEAENPQEQPDPLDMTRIHPENYEFAQKMCQDALDLDVEDVADRHKSEVVQTLMLDDKRGKKLGELNLDDFAFNLQRQGEGNKRHTLGEIVSELIRYRSDRRPAFYVPTDWEIVTMVTGETERTVGRGLKVTATVRKAISARVFCQLESGLDAVLERDYVADEDQAPVTSCDEVFKPRQAIKGVVIMPEPARFQVRISTRPSDLRQGVDFVQPFKDEEYNSKDRRDAAEAATAAKKQRRAGKVQRIVNHPNWHVLNSGQAEQFLASQHRGDCVIRPSSKGPDRIAVTWKVDEDVYQHIDVQEIDKPNEYSLGRILMVSGQYRYSDLDDLIINHVKATARKFDEIQMHEKYKPEHELDAFLKNYVQAHPGRSIYGFSVDSDRPGYLKLCFLSKPTKDGGVIQTWPVRVLPGAYKLGNAIVPGVTELSNAFKMQYSEKLAEQGHQGKTPGIYLGKTPMHLGGRTPALGSRTPAMGSRTPALGSRTPALGSRTPALGSRTPAQGGPRY
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNIGININTDKDISRNILDKIFQYIHEECSEAKIKVFYDSKGLDNEESRALDAVMVLGGDGTILGTARALAKYDVPIFGINRGHLGFLAEIELEDCKKAIKNLFKGQYKIEDRIMLKCDLKGIDKKDDFLALNDIVLTKGNLSRIVKYSIYVDDVWYTTFVADGVIVSTPTGSTAYSLSAGGPIVYPDLDVLEIAPICPHSLGIRPILLNGNSKINIRVLKKYEDPVLTIDGQRYKKVTVNEVTISKSEYKCRLIKFKDKDYFKILRTKISYRSRECEGE
The following text describes a protein:
Function:
Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.
Sequence:
MSDAYLALETGDVVEATARAPGMARGELVFTTAYTGYEESLTDPSYEAQVLTFAYPLIGNYGVRPERTESDRVHPSAVVARELTDDVADWLRTEGVPAVDGIDTRDLVLDIRDGGAMQVGIAAGPDASPATARAQLADCPRLSARTEIGAHVSVDTAETHGNGDTTVALVDCGAKRSIIDAFVARGATVHRLPYDATPADIAAVDPDLLFISNGPGDPANFDAAEHLVDEYIGTVPIAGICLGQQIVARALGGDTEKMDFGHRGVNQPVLDHDSGRVVMTTQNHGYTVADPGDLTVTQVNVNDGTPEALDSAPLDVLTRQYHPEANPGPHDTRGFFDDVLAMADASYTPATAD
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop.
Subcellular Localization:
Mitochondrion.
Sequence:
MSQVTARVLNSGMRLPPLPTIRELVKLYKLQAMKQLSQNFLMDERLTDKIVKSAGRIDPRDIVLEVGPGPGGITRSILRRQPQRLILVEKDRRFGETLQLLRECASPLDMQVDIYYDDILRFNIEQHIPDTTQRIHLIGNLPFSISTRLLINWYADLAARRGAFRRNDTCMTLTFQKEVAERICAPVGSEQRCRLSVMSQIWTEPVMKFIIPGKAFVPKPQVDVGVVKLIPLKQPKTQLPFSLVERVVRHIFSMRQKYCRRGYGTLLPPDSREETTQTLFQRADVRDTLRSFELSVPQCLRLADAYAEYIKEHPEVEAYDYRGPKNPDVSGAAAASS
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMDFIDSDAVIEERTGADISWIFDLEGEDGFRKREERIINELTQMQGIVLSTGGGAVLSKENRNYLSARGIVIYLETTVEKQFQRTQRDKKRPLLQDAENPRQVLEDLAKIRNPLYEEIADITLPTDEQNAKIMVNQIVDLIDNMNGLNGAL
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MRIFYYLYFLCYVTFILPATCTLVDADRCTKRYGRCKRDCLESEKQIDICSSARKICCIERLYEEDGMF
The following text describes a protein:
Function:
Has a role in establishing cell polarity. Together with cAMP-dependent protein kinase regulatory subunit BCY1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways; When associated with DBP5, GFD1 and nucleoporins at the cytosolic fibrils of the nuclear pore complex, is required for mRNA export form the nucleus.
Miscellaneous:
MISCELLANEOUS: 'ZDS' means 'zillion different screens' as both ZDS1 and ZDS2 have been found by a wide variety of genetic screens; MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Note=Concentrated at incipient bud site of unbudded cells and at the bud tip of small and medium-sized buds.
Sequence:
MSNRDNESMLRTTSSDKAIASQRDKRKSEVLIAAQSLDNEIRSVKNLKRLSIGSMDLLIDPELDIKFGGESSGRRSWSGTTSSSASMPSDTTTVNNTRYSDPTPLENLHGRGNSGIESSNKTKQGNYLGIKKGVHSPSRKLNANVLKKNLLWVPANQHPNVKPDNFLELVQDTLQNIQLSDNGEDNDGNSNENNDIEDNGEDKESQSYENKENNTINLNRGLSRHGNASLIRRPSTLRRSYTEFDDNEDDDNKGDSASETVNKVEERISKIKERPVSLRDITEELTKISNSAGLTDNDAITLARTLSMAGSYSDKKDQPQPEGHYDEGDIGFSTSQANTLDDGEFASNMPINNTMTWPERSSLRRSRFNTYRIRSQEQEKEVEQSVDEMKNDDEERLKLTKNTIKVEIDPHKSPFRQQDEDSENMSSPGSIGDFQDIYNHYRQSSGEWEQEMGIEKEAEEVPVKVRNDTVEQDLELREGTTDMVKPSATDDNKETKRHRRRNGWTWLNNKMSREDDNEENQGDDENEENVDSQRMELDNSKKHYISLFNGGEKTEVSNKEEMNNSSTSTATSQTRQKIEKTFANLFRRKPHHKHDASSSPSSSPSSSPSIPNNDAVHVRVRKSKKLGNKSGREPVEPIVLRNRPRPHRHHHSRHGSQKISVKTLKDSQPQQQIPLQPQLEGAIEIEKKEESDSESLPQLQPAVSVSSTKSNSRDREEEEAKKKNKKRSNTTEISNQQHSKHVQKENTDEQKAQLQAPAQEQVQTSVPVQASAPVQNSAPVQTSAPVEASAQTQAPAAPPLKHTSILPPRKLTFADVKKPDKPNSPVQFTDSAFGFPLPLLTVSTVIMFDHRLPINVERAIYRLSHLKLSNSKRGLREQVLLSNFMYAYLNLVNHTLYMEQVAHDKEQQQQQQQQP
The following text describes a protein:
Function:
Protein adapter that acts as an essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes. Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation. Not required for piRNA biosynthesis.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MPVDKFLARAGGQRTLSRFQDSLCDFLATGSSRSLCGTSLDFPDRVLVCTEGPAGMEEASSPSFRQATTVEGMVSPEDPTLSKEGLSAKGPPPSPVLPPFRRKCRKCGICPQEEEKSGFSLRFGQRPDGDPPECASPEAFAGPPRLLSSKDTEPGEPGGSWVECAVETEVENMLFSKDGVAPDSLDHLFEFPGLFGGEPLSLVTQEPLQSPALYPEVLTEDSTDQQEVQPAFVVGSPGTPPDPVGPEDKAQSGSRMELEQGLSAPANSCASSPEPLGGLDGAPLEQRRPTHVKKRPWTSPDDSSQDHAEGASKKDFPRLEARVPRGVKTVYYVYTGSGIRLVGAASSSQPGQIEPLEELDTNSARRKRRPTTAHPTPCQSDPSETENAEPHQQRAEDPGEQGMTPLDAGVRSTVVRAMQEVLWTRAQELPDLALREDEVEAIAEGIEEALFHLTQDTNLRYKNKYRSLLFNLRDPRNVDLFLKVAHCDVTPNNLVQMSSIQLAPKELSRWRDQEERKGLDIIEQQQKELYRLPASKLTHKGEVEIPRDLDQMLTLEDLMEPIVPRECSLQPLSTPLEDTTNWHQHHQCDSNCQICTGGEEGRKADDGSQPELQVDISYNVDRKSSTKLPAFSGVIMNREENAIQKAPGPAPASSPEVLKVGETPPKEPQDRLQMPAGLKNAPPSPPPWEGSLDMFSIKHFRAKAQLISGHSCQLVQALPDVIRSAGRLPPSHVWDLLDSMGPSKAKDICVIRLCPHGSRDIQNYRLLYSYLNNKQCHCLATVQQVKMVLLPLPAFEPLPARLRPLGGPGLEITHTSLLLAVLFPKDALPDTATSIPVSNKVPKTVSFSKRVERILYSPEDRRSEATSSPLEEDPKQSLARGSLAPRSVCAPQSFPRGRGRQGPGWGQWSPEAAWCYSQHPSSAGPVFPGIGQGQHLHRASCFHHDLLQHLKVLVTMSHQFQASLWPQSQDSLPPSTVVSAVPDPPGPSLGPMDGGGSNCPPPEGSDPLEPPEHEC
The following text describes a protein:
Function:
Involved in callose synthesis at the forming cell plate during cytokinesis. During plant growth and development, callose is found as a transitory component of the cell plate in dividing cells, is a major component of pollen mother cell walls and pollen tubes, and is found as a structural component of plasmodesmatal canals (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASTSSGGRGEDGRPPQMQPVRSMSRKMTRAGTMMIEHPNEDERPIDSELVPSSLASIAPILRVANDIDQDNARVAYLCRFHAFEKAHRMDPTSSGRGVRQFKTYLLHKLEEEEEITEHMLAKSDPREIQLYYQTFYENNIQDGEGKKTPEEMAKLYQIATVLYDVLKTVVPQARIDDKTLRYAKEVERKKEQYEHYNILPLYALGAKTAVMELPEIKAAILAVCNVDNLPRPRFHSASANLDEVDRERGRSFNDILEWLALVFGFQRGNVANQREHLILLLANIDVRKRDLENYVEIKPSTVRKLMEKYFKNYNSWCKYLRCDSYLRFPAGCDKQQLSLLYIGLYLLIWGEASNVRFMPECLCYIFHNMANEVHGILFGNVYPVTGDTYEAGAPDEEAFLRNVITPIYQVLRKEVRRNKNGKASHSKWRNYDDLNEYFWDKRCFRLKWPMNFKADFFIHTDEISQVPNQRHDQVSHGKRKPKTNFVEARTFWNLYRSFDRMWMFLVLSLQTMIIVAWHPSGSILAIFTEDVFRNVLTIFITSAFLNLLQATLDLVLSFGAWKSLKFSQIMRYITKFLMAAMWAIMLPITYSKSVQNPTGLIKFFSSWVGSWLHRSLYDYAIALYVLPNILAAVFFLLPPLRRIMERSNMRIVTLIMWWAQPKLYIGRGMHEEMFALFKYTFFWVMLLLSKLAFSYYVEILPLVNPTKLIWDMHVVNYEWHEFFPNATHNIGVIIAIWGPIVLVYFMDTQIWYAIFSTLFGGIYGAFSHLGEIRTLGMLRSRFKVVPSAFCSKLTPLPLGHAKRKHLDETVDEKDIARFSQMWNKFIHTMRDEDLISDRERDLLLVPSSSGDVTVVQWPPFLLASKIPIALDMAKDFKGKEDVDLFKKIKSEYYMHYAVVEAYETVRDIIYGLLQDESDKRIVREICYEVDISIQQHRFLSEFRMTGMPLLSDKLEKFLKILLSDYEEDDYKSQIINVLQDIIEIITQDVMVNGHEILERAHLQSGDIESDKKEQRFEKIDLSLTQNISWREKVVRLLLLLTVKESAINIPQSLEARRRMTFFANSLFMNMPDAPRVRDMLSFSVLTPYYKEDVLYSEEELNKENEDGITILFYLQRIYPEEWSNYCERVNDLKRNLSEKDKAEQLRQWVSYRGQTLSRTVRGMMYYRVALELQCFQEYTEENATNGGYLPSESNEDDRKAFSDRARALADLKFTYVVSCQVYGNQKKSSESRDRSCYNNILQLMLKYPSLRVAYIDEREETVNGKSQKVFYSVLLKGCDKLDEEIYRIKLPGPPTEIGEGKPENQNHAIIFTRGEALQTIDMNQDNYFEECFKMRNVLQEFDEGRRGKRNPTILGLREHIFTGSVSSLAWFMSNQETSFVTIGQRVLANPLRVRFHYGHPDIFDRIFHITRGGISKASKIINLSEDIFAGYNSTLRGGYVTHHEYIQAGKGRDVGMNQISFFEAKVANGNGEQTLSRDVYRLGRRFDFYRMLSFYFTTVGFYFSSMITVLTVYVFLYGRLYLVLSGLEKNILQSASVHESNALEQALAAQSVFQLGFLMVLPMVMEIGLEKGFRTALGDFIIMQLQLASVFFTFQLGTKAHYFGRTILHGGSKYRATGRGFVVFHAKFAENYRLYSRSHFVKGLELVILLVVYQVYGTSYRSSSTYMYITFSMWFLVTSWLFAPFIFNPSGFEWQKTVDDWTDWKRWMGNRGGIGIVLDKSWESWWDIEQEHLKHTNLRGRVLEILLALRFLLYQYGIVYHLNIARRHTTFLVYGLSWAILLSVLLVLKMVSMGRRKFGTDFQVMFRILKALLFLGFLSVMTVLFVVCGLTISDLFASILAFLPTGWAILLIGQALRSVFKGLGFWDSVKELGRAYEYIMGLVIFTPIAVLSWFPFVSEFQTRLLFNQAFSRGLQISMILAGKKDKETPSTKYLGHTEESFGLEHDTNTFNHYYLWT
The following text describes a protein:
Function:
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity).
Subcellular Localization:
Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Cell projection. Note=Colocalizes with RPSA/LAMR1 in the cell membrane (By similarity). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (By similarity).
Sequence:
MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLLHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAAGQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMPMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFSTKISRGELDGPVENGLRAPVSTYQYALANGDIWKMHEMPDYSMAYGNPGVADVPPPWSGFKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSVARSGESSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPMEEMEEKVHGCCRIS
The following text describes a protein:
Function:
Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.
Sequence:
MFTLPQKDFRAPTTCLGPTCMQDLGSSHGEDLEGECSRKLDQKLPELRGVGDPAMISSDTSYLSSRGRMIKWFWDSAEEGYRTYHMDEYDEDKNPSGIINLGTSENKLCFDLLSWRLSQRDMQRVEPSLLQYADWRGHLFLREEVAKFLSFYCKSPVPLRPENVVVLNGGASLFSALATVLCEAGEAFLIPTPYYGAITQHVCLYGNIRLAYVYLDSEVTGLDTRPFQLTVEKLEMALREAHSEGVKVKGLILISPQNPLGDVYSPEELQEYLVFAKRHRLHVIVDEVYMLSVFEKSVGYRSVLSLERLPDPQRTHVMWATSKDFGMSGLRFGTLYTENQDVATAVASLCRYHGLSGLVQYQMAQLLRDRDWINQVYLPENHARLKAAHTYVSEELRALGIPFLSRGAGFFIWVDLRKYLPKGTFEEEMLLWRRFLDNKVLLSFGKAFECKEPGWFRFVFSDQVHRLCLGMQRVQQVLAGKSQVAEDPRPSQSQEPSDQRR
The following text describes a protein:
Function:
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Domain:
A functional Walker motif (consensus sequence G-X-X-G-X-G-K-[ST]-T) is expected to bind ATP. The essential Lys in this region is not conserved in ABCG8 (G-S-S-G-C-R-A-S) and is not required for transport activity mediated by the heterodimer with ABCG5.
Sequence:
MAEKTKEETQLWNGTVLQDASSLQDSVFSSESDNSLYFTYSGQSNTLEVRDLTYQGGTCLRSWGQEDPHMSLGLSESVDMASQVPWFEQLAQFKLPWRSRGSQDSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDLTSIDRRSKEQEVATMEKARLLAALFLEKVQGFDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGTAAELPGMIQQFTTLIRRQISNDFRDLPTLFIHGAEACLMSLIIGFLYYGHADKPLSFMDMAALLFMIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVIIYGMPIYWLTNLRPGPELFLLHFMLLWLVVFCCRTMALAASAMLPTFHMSSFCCNALYNSFYLTAGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFNGHIYTTQIGNLTFSVPGDAMVTAMDLNSHPLYAIYLIVIGISCGFLSLYYLSLKFIKQKSIQDW
The following text describes a protein:
Function:
Serine protease inhibitor (Probable). Probably by inhibiting serine protease tyr-5 in males, prevents the maturation of spermatids into mature motile spermatozoa until their transfer into a hermaphrodite. Also required for efficient sperm transfer and thus for male fertility.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Note=In males, partially colocalizes with tyr-5 in vesicles near the apical membrane of cuboidal cells. Secreted predominantly by muscles into the pseudocoelom where it enters the seminal vesicle in males and the spermatheca in hermaphrodites. Localizes around the spermatocytes at the late stages of meiosis. During mating, transferred together with sperm into hermaphrodites where it spreads into the uterus. Also, is uptaken by coelomocytes.
Sequence:
MRILVIITCIVAVATATKTCEANEELVSCHNTCEPQCGYTPKACTEQCIMNTCDCKDGFVRNSLGKCVEVSECTKETTKCPENETFFGCGTACEATCEKPNPTVCTKQCIVNVCQCSKGFVRHGLRCIDKKDCPK
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 1460 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSDNDGLMLMNFTTESGPDNASSHRRVKVTGGKWKERRKLKMKLEGRPLRPKRPAAAVEEAPAAAVPEGSAIEPAAKRPRGRNERAPKDVPPQPANAQVVSSLFTSTRAITTSVNDHERASNDVAPSNAPLLQDTFEALGVRGTLLEHLTGKMKIQKPTKIQKMAIPEVLNGKADLFLHAQTGSGKTLAFLLPVLQTLLSLEQRIDRHSGCFAMIVTPTRELAAQIYGVISTLAQCCHYLVPCLLVGGERKKSEKARLRKGANFIVGTPGRMLDHLQNTKVAREQLPHSLRYLILDEGDKLMELGFEETLKSILEIVHSVACDNTRFPRLPQRIVHVLCSATRQGTVSKLGDIALTDPKVIAASDSTTDVSTVPDQLLQKIAIVPPKLRLVTLCAAISELSRKAPTETTTRTIVFISCADSVDFHYDVFSGLGGSHRDLVPGTVRELAAGSRALPCFSADSPPNTVFYKLHGSLPQAVRVATLRHFSSDAAATRGKHLVLFCTDVASRGLDLPRVSTVIEMDPPFAVEDHLHRIGRTARAGVAGESLLFLLPGEEEGYMEHIRAHHPRGWELLRYDRDLLAPAFAAPVARSDRPTTATDAAWDSNATTWHLNVERRVLEDPSAKDLAIKGYTSHIRAYATHISQEKRFFNVRCLHLGHLAKAFGLRERPKGMAAHRGKPATPKPKQDDARTKMLRMARQAVAQSNSEFNY