lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTRLVLGSASPGRLKVLRDAGIEPLVIASHVDEDVVIAALGPDAVPSDVVCVLAAAKAAQVATTLTGTQRIVAADCVVVACDSMLYIEGRLLGKPASIDEAREQWRSMAGRAGQLYTGHGVIRLQDNKTVYRAAETAITTVYFGTPSASDLEAYLASGESLRVAGGFTLDGLGGWFIDGVQGNPSNVIGLSLPLLRSLVQRCGLSVAALWAGNAGGPAHKQQ
The following text describes a protein:
Function:
Required for the maintenance of microtubule structures and cell polarity. Beta-tubulin-folding protein; may have a regulatory role in the tubulin-folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSNTVRSLVIKTNVVKRIIKDVELAHIDINEAEKRVQSKIDNGEDSAEIEHQKFVLKKHLEALPDALVRLRNATNDLESISSDSAYEGTPELEQANEYLEKAKEVIEKEQTNFPTNGYH
The following text describes a protein:
Function:
Transcription factor that binds to the E-box-containing promoter regions of the transcription factors TDR and EAT1, activating their expression. May have a role in specifying the cell pattern of the inner anther walls and functioning in meiosis progression. Required for male reproduction. Acts downstream of UDT1 and GAMYB, but upstream of TDR1 and EAT1 in pollen development.
Subcellular Localization:
Nucleus.
Sequence:
MYHPQCELLMPLESLEMDVGQSHLAAAVAAAMPGELNFHLLHSLDAAAAAASSTAASASSQPTVDYFFGGADQQPPPPAAMQYDQLAAPHHHQTVAMLRDYYGGHYPPAAAAAAATEAYFRGGPRTAGSSSLVFGPADDESAFMVGPFESSPTPRSGGGRKRSRATAGFHGGGPANGVEKKEKQRRLRLTEKYNALMLLIPNRTKEDRATVISDAIEYIQELGRTVEELTLLVEKKRRRREMQGDVVDAATSSVVAGMDQAAESSEGEVMAAAAMGAVAPPPRQAPIRSTYIQRRSKETFVDVRIVEDDVNIKLTKRRRDGCLAAASRALDDLRLDLVHLSGGKIGDCHIYMFNTKIHSGSPVFASAVASRLIEVVDEY
The following text describes a protein:
Function:
Probable transcription factor that regulates lignified secondary cell wall thickening of the anther endocethium, which is necessary for anther dehiscence. May play a role in specifying early endothecial cell development by regulating a number of genes linked to secondary thickening such as NST1 and NST2. Acts upstream of the lignin biosynthesis pathway.
Subcellular Localization:
Nucleus.
Sequence:
MGHHSCCNKQKVKRGLWSPEEDEKLINYINSYGHGCWSSVPKHAGTYTHIHGFCLQRCGKSCRLRWINYLRPDLKRGSFSPQEAALIIELHSILGNRWAQIAKHLPGRTDNEVKNFWNSSIKKKLMSHHHHGHHHHHLSSMASLLTNLPYHNGFNPTTVDDESSRFMSNIITNTNPNFITPSHLSLPSPHVMTPLMFPTSREGDFKFLTTNNPNQSHHHDNNHYNNLDILSPTPTINNHHQPSLSSCPHDNNLQWPALPDFPASTISGFQETLQDYDDANKLNVFVTPFNDNAKKLLCGEVLEGKVLSSSSPISQDHGLFLPTTYNFQMTSTSDHQHHHRVDSYINHMIIPSSSSSSPISCGQYVIT
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the export of sodium and potassium from the cell. Appears to export potassium more efficiently than sodium. May transport other cations such as lithium (By similarity). Sodium/potassium efflux ATPases are involved in salt tolerance and maintaining the membrane potential across the plasma membrane in high salinity (Na+) or alkaline (K+) environments.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MMGANSTEWHGQSVEQVTELLGTDVERGLKESVVGQLQKQFGPNELKGQRGVNPWKVLLAQFTNGLTVILLIATVVSFAVQDHAEGGVLAFVIIFNASVGFVQEYRAEKTMDALRRMASPTAKVIRDGGLDRISSPGVVPGDIIVFEVGDVVPADCRLIEVLNLEVDEAMLTGESLPVAKTVEAIKGENATVGDRLNMVYSSTILTKGRGKGIAVATGMSTEIGKITKSISETGQSSTPMQKRLNRMAYILFGISLVLAVIVFAVNKFEFNTDIIIYAVSLGIAVIPEGLIAVITIVMALGVRRMASQQALVRKLVALESLQAVTNICSDKTGTLTQGKMTVTTLWLPGMEDQYSISGNGWETSGEISVREQPIDAQECLSDLRFRLLVECSALCNTANIVEASEGKVWGDPTEIALQVLAYKLQMGKPSFRSRKEPITEYPFSSAEKRMSMLYRDVERDAFEIYTKGAENVLAICDRLLEKGEEVEISSRDEFMQSVSAQIQIMAKQGLRVLVVAYRTVSEKEMAKSVSKWERVDVERNMTFLGLVGIRDTPRPESRIAVDQCYEAGIIVHMLTGDHHDTALAIAREVGIIRPAPNSADESVVPMSNPVMTAAEFDALSEEQIDDLNELPLVIARCTPATKVRMIEALHRRKKFAAMTGDGVNDAPSLKKADVGIAMGAGSDVAKQSSEIVLTDNNFATIVMAVSEGRRIFSNIRKFILHLVSTNVGEVIVLIIGLAFKDRNGVSVFPLAPVQILFMNMVTSTPPAMALGVEAASKDTMKVPPHTKGLFGKEVLADMMVYGIIMGSLILVDWVLVIYAFGDSQLGLECNSDRMLNECNTVFRARSTIMVALIWMLLLHAYNCRHPRASLFTAEGGGASKLFSNRLLVWSVLLGSLMPIPTVYIPTLNTKIFKQETISWEWSIVVVSVVAFFFLSELYKLIKRNVMTSRVI
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MKSVIANFLFVLVAVVACARSAAAAKCSDHLLSMKADDFSEEDGGKYDHTACSASFSNFYKYTPQFQGLITEHISQSFIYSIMSSHFETDYENRLGFSKYLDGLSDNMWQQAISLIKYAGKRGSGVAPIDSSSGLSINNLSAGIKPWTEVEALALALDHHQMLALKVHQLHGSVKDAAFGDFLENQFVSEHVSRIRELSGHLTNLVPMVQEEVSKDLALYLFDQSLA
The following text describes a protein:
Function:
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Sequence:
MPVRIIDHVYAQYLLTKLRDKNTGSIEFRKGLVRLGRIIGYELAKTFPVKYVEIETPLGKAVGVDIIGLDKVVIVQVLRAAMPLVEGLVKAFPQARLGVVAAKRREEGGVVDVDIFYSKVPKIAEDDVVIVADPMLATGITMSRVIEEVYRAGNPGRLIVVSVIATPMGIERVLSRWPSAEIYAVAVDPTLNDKAFIVPGLGDAGDRAFAT
The following text describes a protein:
Function:
RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSASVEYQPPGAESELDRTVGGPRRRRHDDDDEGPDNSDDDDLESTTSAPANKAKYPGELEEEKELAPHACAYCGIHNPSSVVKCLACSKWFCSARGNTSSSHIVNHLVRARHKEVQLHPESSLGDTVLECYNCGTKNVFLLGFIPAKSDTVVVLLCRQPCAAMPSSKDMNWDTSRWQPLIEDRSFLTWLVAAPSDQEQLRARHLSPQMIAKLEEMWKENSQATIADLEKATAVDDEPAPVLLRYDDAFQYQNIFGPLVKIEADYDRKLKESQSQDGLIVRWDLGLNNKHLASFILPKLELGDVKLAVGDEMRLKYTGELRPKWEGVGYVIKIPNNQSDEVTIELRAKGDHKSVPTECTHNFTADYVWKSTSFDRMQLAMKTFAVDEMSVSGYIFHRLLGHEVAAAPMKTQMPKKFSVPGLPELNGSQINAVKSVLQRPLSLIQGPPGTGKTVTSATIIYHLAKLNGGQVLVCAPSNVAVDQLCERIHRTGLKTVRVTAKSREDVESPVGFLSLHEQVRLNDSNIELIKLNQLKSELGELSSQDEKRLKQLTRAAEREILNNADVICCTCVGAGDPRLAKLKFRTVLIDESTQSAEPECMIPLVLGCKQVVLVGDHQQLGPVIMNKKAAKAGLNQSLFERLVILGCSPIRLNVQYRMHPCLSEFPSNMFYEGSLQNGITSFDRLRREVDFPWPILDSPMMFWSNLGNEEISASGTSYLNRTEAANVEKIVTRFFKAGVQPKDIGIITPYEGQRSYIVSSMQATGTFKKEHYKEIEVASVDAFQGREKDFIILSCVRSNDHQGIGFLSDPRRLNVALTRAKYGLVILGNPKVLSKHPLWNCLLQHFKERHTLVEGPLSNLQESLIQFSRPKQAYRGPQRFQMAYNHVSNVTSGFMNGRNGHRNEFHDTGSVVGYIPDDVSSVHSSALGGVGIPSGYPPMFQQFADSWPSLPGARRANGNRGKGAPSIAGDSVAATESDITGSIIDGKGPEQGGVSLAGLSINDMTKQPSLSQSDRLKRYVESGARDPYKPGAPDSGSIFGGSSASIRVTRGIPGHIHDDDDARSVSTAFASQVGGNYD
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MGSMFLDSPSLAPNRLIRVSILTERSAVGSGQDHNAAVRDSGSLVLSPNGKGQPEIAVTDLVPCGGPTSSSLVETQDGIGIVKFLRGKCFFISGATGFLAKDFLCPEFFLLLMIINTYHMLKPAVLIEKILRTMPDVGKIYLFIKAKDKEAAIARLKNEIINAELFKCLRETYGVSYQSFMLSKLVPVVGNVCESNLGFEEDLADEIANEVDVIINSAANTSFDESMCFQAIFYCCIVTLWKCRYDVAIDVNTRGTCHLVRFAKCQKLKLFLQVSTAYVNGQRQGRIMEKPLCLGDCIARENPIVSGSTALDIENEVKLAVNSKEDFQENEGKRYGWQDTYVFTKAMREMVVDNMRGDIPVVVIRPSVIESTWKEPFPGWMEGNRMMDPIVLCYGKRQLTGFLADPNGVLDVVPADMVVNATLAAIAWHGMEQKSDINVYQIASSVVNPLVFQDLATLLYEHYNSSPYMDSNGRPIHVPSMQLFSSMEDFFVHLWRDVIQQSRLAEMASSDRKLSQKHENICRKSLEQAKYLANIYEPYTFYGGRFDNSNTQKLMERMSENEKGEFGFDVGSMDWRDYITNVHIPGLRRHVMKGRGMCG
The following text describes a protein:
Function:
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSSSAEGYSNLRKRFSSKHEYQAEKSVNDWSTKSERGSLDDDDERLVLKKPLSKVQKAFKFGLIPLALTAAAFFVRFWKISDSNIVVWDEAHFGKFASYYLKREFYFDVHPPLGKMLNALAGYLAGYDGQFGFESGAAYPEGMNYSFMRYWNATFGALCVPLVYFTSLNFDFSTLAATLASLMVCLDNHLATISRFILLDSMLLFFTFATFFCLSRFYVFRKAPFSFRWYKWMFLTGVCIGSVTSVKLIGLFVTSVVGIYTIEELWRFLGDRRMKTTTYVHHWIARIVCLIIVPISVYMLSFKAHFIVLSNSGPGDAQMPSLFQARLNGSPMADNPIDLLYGYHHKDDNNNWYFFPPHGPSRYFPEQDDSLTPIVHGSLVRMFHPATGRNLHTHSVPAPVSSGQYEVSCYGNSTIGDEKDYWIVEVVEDTLTGNKTGVHALSSVIRLYSPVMKCYLAMDKANLPSWGFSQREVTCDPNASPKDVRTHWNVEEHYNPRLPAAPKDFIHLNRAMLETNNALVPDDDKFDALRSEAYQWPFLLATLRMCGWGDNQIKYLLIGNPFSYWLSTACIGVFLLLCVTYFLKWRRHTLKLTSTEIEKFRVAGIYPFLGWFFHYFPFFIMGRVLYVHHYEPAFAFSAITAAFTIDWCTRKMPCAVRFVIFTILYVAIIAVFVFFKDVTFGMHGPASDFHRLRWLKSWNVHD
The following text describes a protein:
Function:
Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MVLAMESRVAPEIPGLIQPGNVTQDLKMMVCKLLNSPKPTKTFPGSQPVSFQHSDVEEKLLAHDYYVCEKTDGLRVLMFIVINPVTGEQGCFMIDRENNYYLVNGFRFPRLPQKKKEELLETLQDGTLLDGELVIQTNPMTKLQELRYLMFDCLAINGRCLTQSPTSSRLAHLGKEFFKPYFDLRAAYPNRCTTFPFKISMKHMDFSYQLVKVAKSLDKLPHLSDGLIFTPVKAPYTAGGKDSLLLKWKPEQENTVDFKLILDIPMVEDPSLPKDDRNRWYYNYDVKPVFSLYVWQGGADVNSRLKHFDQPFDRKEFEILERTYRKFAELSVSDEEWQNLKNLEQPLNGRIVECAKNQETGAWEMLRFRDDKLNGNHTSVVQKVLESINDSVSLEDLEEIVGDIKRCWDERRANMAGGSGRPLPSQSQNATLSTSKPVHSQPPSNDKEPKYVDEDDWSD
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).
Subcellular Localization:
Nucleus.
Sequence:
MTEGVTVQKVQSASSNGHKPNTVISQIISEMQSLLGSSFEVYTKTMTDFLIGQLSRKEMKSMLLTFAGKSNFDKLHNSIIFHILKLMQKNNDTFSALHHLPWFKRKKVDNSLFLHKKISSQNAQVRLIKRIVMSLSYKDRARIKTALKEKPVTPSLISGLLLETRIAKLPKIPVSRDKLNSVFVNDIKAGYVAPLACETLELPDSESLKERITAISLENGLLGGVQKGVSDIILAGLESHLKNILSRCFSILNKNIRQKNTENDAAGFTINDLNLAWTIEPHAFVEQYPQKLRMPFLLHDSYTEDEISICAESPSYMLASNDAQSDRNSVASLLDEVLS
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVKRKKHDKDKYYNLARQQGYRARSAFKLIQLNKKYDFLSTAKVCIDLCAAPGGWCQVAAKYMPASSIILGIDLLPIRPIRGVKTFQCDITTVRCRQIIKQEMQSWQADVVLCDGAPNVGAEYSKDAYVQNELALVALKLAVDVMGRGGTFVSKVFRSQDYNALLWVFKQLFKKVSATKPLSSRNESAEIFVVCEQFLAPHSIDPKLFDPKYVFDQVDAQEKTITIFHPKFGDRKRHREGYDEALGVMLTNECSVSQFIDEHDPIRLLTDTTSIKFMPEDDVFRDHKDTTDEIVTCLNDLKVLGKGDFKSLLKWRTRMQKYKEELLKAENPEEEDEKEKPAEKEPERDLTEKEKDALVREELSQLRANVQAKKKREKKKERERKQKLRIRAALGMNAEGIDVTEVESAFSLKELKLSKEKVDVLENAGADSSSDEELQFETDDEDEDAGLEDSDAEYDELLEASMEKAYEQFLTRRGDDVKTRKAVKRTKIAKRALAGEALVQDSEMFDGDMQKYQKMINPDESSDDSSDDDDDLNVSLKVPEKSSAAMSRWFSDNKLFDGIDEKEDISLPEMPKTDKEIRHEKRVAALERKERRAKKKLKKEEKEYELEFGTEFDVAAPADSDDEAAMAAEAAEESDDETSAEKKALIRSGMGAALKSDQSTSDKYEVVAAGDEPDENALPAMDDRKYDSDHEDYDAEDRAKTLALASMMVQKSKAKDLIDASYNRYAWNDSEAIPDWFADDEEKHYRPQIPIPKNVLAQMKERFMEMATKPVKKVAEARGRKHRLQMKKLKSAKKQATDIANLPDMSTREKLKAIDRAMRGANVKKESKVYVVSTRGGTKTAGGKKAGKGKVKLVDPRMKNDKRNADIRAKRGKKRKR
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
AEEGDDSGSEFKAGDIDSHDESLDHIDEDSEEEFSEEEEFDDVDPKKKPKKKSKVTIRGSSAPKSAAVASSFASSSAGTTASKHSPMAVSQTQQEQSTAPPKPIAKTVNQAGSHFHNHLTFFTSGRRDMNKHAPNHPDYSPRTLLVDYNELERKHKEIGGTLSPAQRQWWDIKCHYADTVLLFKTGKFYEMFHDDADVGVAHLDFNYMSGTAAHAGFPEAAYDKFVGILVEKGYKVARVEQTETPDMLNERKKRTSGKKPSVVNREVCCVVSKGTRTFCYLEDTSCFEEGSEKKVTTGPLVVIKEVEEEDVAGTKAVCEYGVTVVDAITGVVTLGQFADDILRSRMQTLLASYSPSEVLIEGGAKNFPKSNALDSEARKVLNRTQQNISPWDAEDGVKELHRRAYYPRSSRKNDPSAGGVGGGIGRWPEVLRACVDGGASLALSSFGAALFYLQRSLVDAEILSMGIVKAYIPPNNGLSPTESEALCDHMALDGTTLSNLEILNNLASGSYQGSLLSKIDVTQSPHGSRLLRAWLLRPLFRKVDIDRRADVVEELSGGSAAVSMSEARPLLKKTGDIERLLSRVHSMGQGGGARADGEGPPTGYHPDERAILYENEKHTKRKVGDFSKLLTGLRNAAEIPELFDNAEIQSPMLAKIVRTTDNGGCFPADMKEKLDWFFDNFDLKKASKGEFEPTRGMSEDYDEACDTIVNIKRELEAYKDEMCSSVIRNGKSHWKYINIKEDSKDKYLIELPATVSVPADFELKAKRGKGNNQVNKYRTPEVAGLVKELERAIDVKAAGKASGMKLVFAKFDSMRNVWMAATHATAMLDALGALAEVAVMPGFSRPQIVDCLPNTKPGIKVVQGRHPCVGITHSGDDFIPNDLTLGGKMGLDENDSNDESSVLLLSGPNMGGKSTLLRQTCLITILAQIGSFVPAEQCALTPVDRIFTRLGASDRILCGQSTFFVELAETAAAVRGATRRSLVIMDELGRGTSTFDGTAIASATVKHLVERSQCVTLFATHYHSLLEDWKNEPSIRLGHMECIVEDDSEDDAEKRSNITFLYTLGEGPCPKSFGVNVARLAGLPDDVLQKAKLVSAAFE
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP or pyrophosphate as phosphate donor.
Sequence:
MIAMDIREIGLRLVGEAIKAADPYRAVLNAVKVSDDKIIVQGKEFEIKGKVYVIALGKAACEMARAIEDILDVEDGVAVTKYGYGKELKRIKVIEAGHPIPDEKSILGAKEALSILNRARENDIVFILISGGGSALFELPEEGISLEDLKLTTDLLLKSGAKIHEINTVRKHISKVKGGKLAKMIKGTGIVLIISDVVGDNLEAIASGPTVKDPTTFEDAKRILELYDIWEKVPESVRLHIERGLRGEVEETLKEDLPNVHNFLIASNSISCEAIAREAQRLGFKAYIMTTTLEGEAKDAGLFIGSIVQEIAERGRPFEPPVVLVFGGETTVTIEGKGGKGGPNQEIALSATRKISDLEALIVAFDTDGTDGPTDAAGGIVDGTTYKKLREKGIDVEKVLKEHNSYEALKKVGGLLFTGPTGTNVNSIVIAIVTSKRGRT
The following text describes a protein:
Function:
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).
Sequence:
MYIKQIRLKGFRTYKNETTIDFTRGINCIVGFNGSGKSNILLAIEFILSDVCEYKQIYLHEGIGNAVRNCYVEIIFDNSEKYFSMFKESEIKIKKVLENMKCEIFVNDKNISKNQYVELLESCGLCINNLYNIIKQGQIIKLSNMKDEEILNYLKSILGAKIFEEKKKDALSMLKECDSKKVTIEKEFNDMNSKLESLQEEFENFLEYKKLEKEKVHLDYFLNEINYKNIYEETQMLKSKLQELKNKTQDEDNHLNLSNNNKSEYNEKLNKMKLEIASCQNHLNKTISEDIQNKRNIVHLQMLIDEKIKEKNIKESQNKNRIKNINQINEFILRVNEKLQSLKSDIVSKEKQIENKNNEINMLLSKNKNKNTDANYSHNVKKIEKMINDINIELSFLEKETIKNEKYLKELEEESKVLNKSIKENETLSQKYGSEINELNNKSEKCVEQKRQCQQKISEGTTNLNEIKCQIIEVNDKYDEIIKSSNKEILKIVDLIMAEKSIKRENILGFLIDNINVDKTYVKAVDTILENHYFTLIVEDMQTAKKIVEFIEKKREERTSKEFNFKEFYFGKLTIVPLLNIKKFNEFNYPNDKNIVPLIKCVNYNSKIYEFLKNILFKTIIVKSLESCENYLEDNYNCVNIDGDYLSKHGFMYGGYNKKKYGIYTVYNKLKELKEEEKKEKSHIEELNNNIEKIDDELRNIYDTKSSTVAKKNGCASTINSINNNIYSNEENIRLTSEKINYIQEKKQNLEQHKDQLKMQILQLRNNNVNPDESEKVGSTDINSLNDEVKKLKEELNKIRNEYDDFKNKLELLYQKRNENDSSIYMEEYEDVDIDEYNNDLADKKDHSDKIEKEKIHYEQKIREINKEMENVKSSIDKILINEKKHKKKILDLCHQMNQINEELRILEGKEENIRKKKVLLPQGIQELEEYRTYDKQQLSAKLKSVTMELKKYSNVNEKAGDRLNILMNDFNELKKRHEEINSSHKNIKDMIQHIGKKKDEALEATYVKINKYFSEYFSLLFKNRKASLVLKKMNEKEYKEKLQEMSEKRIKRRIIDEEVYIDKITGISINITSNDDEKMTYTIQELSGGERSIVAICLFLCLNKIDNFSFFFFDEIDAALDTIHRDNLSLLLKELAHRGTQFIITTFRKELLEYSDNMYIVKIVDRESYISKGTKNEAYEIISIEEKHALEN
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSTVKAANWRFVEVGRVVLVDNKELATIVEIIDQKRVLIDGPKIQRQAIALAKIVLTPIVLPNLPRGSRTATVTKKWAAADIDAKWAASGWAKKLANKERRSQLSDFERFQVMVLKKQRRFATKKALVKA
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MHSRFIAVTLASLSLASQAVAWGCIGQDCNQAADQIAFSAPEPASYEGKVKSLAWEPTPGQGWQWSSCGTGDEVVNVESIVVSPDPPVPGQNLTVRAKGTVKDEVSDGTFADVIVKLGLIRLLARRFDVCEQARESNADLQCPLSAGEYELEHTVALPREIPPGKFNVHITGENQDGSNLLCLDLSIQFGFRR
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK
The following text describes a protein:
Function:
Probable DNA helicase that may play a role in DNA repair during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MAPPHDVFADADPDPEAEKRAEYVGKLAKFLRKLHSDDVRRILLHPEPNLHFPLVIDFADFLEFDPGLANILYTNPKGFLPLFEEATQLAQNVELGVLNKIEALGNPDELKPAAVQKDFVHVRIDITGSPLEFPESSPSIGKVRVKHRGTLLTLKGTVIRSGGVKMIEGERKYQCRKCNYRFTCYPELEAGNRITLPASCPSMSSRGCQSASFQLIEDSITCHDYQEIKIQESVQLLEVGSIPRSMPVILMDDLVDIVKAGDDVILTGILSAKWSSDVKDVRCNLDPMFIANYVRRTNELKSGIDIPEEIVKEFDLFWAEYGATPLKGRNKILEGICPQIYGLFTVKLAVALTLIGGVQHVDASGTKVRGEPHMLLVGDPGTGKSQFLKFAAKLSNRSVITTGLGSTSAGLTVTAVKDGGEWMLEAGALVLADGGLCCIDEFDSMREHDRTTIHEAMEQQTISIAKAGLVTTLSTKTTVFGATNPKGQYDPNESLSVNTTLSGPLLSRFDIVLVLLDKKNKDLDEIISSHILAQNTKPDKENISDSGVKSTLLPVIKKWTLPLLRRYIHYIKQRFKPVLTKEAERAISGYYQLQRRSGTQNAARTTVRMLESLIRLAQAHARLMFRNEVTQLDAIAAILCIESSMTTSSIIDGAGNALNSNFWENPDQEYIEQEKIILGKL
The following text describes a protein:
Function:
E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters.
Subcellular Localization:
Cytoplasm.
Sequence:
MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCPQCRAPFHMDSLRPNKQLGSLIEALKETDQEMSCEEHGEQFHLFCEDEGQLICWRCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKEKVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHILELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDVKKMLRSHQVSVTLDPDTAHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFTSGRRYFEVDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQPLLVGIFLDYEAGVVSFYNGNTGCHIFTFPKASFSDTLRPYFQVYQYSPLFLPPPGD
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Sequence:
MATSLWKGLVGLGLFALAHAAFSAAQHRSYMRLTEKEDEDLPIDIVLQTLMAFAVTCYGIVHLAGEFKDMDATSELKNKTLDTLRNHPSFYVFNHRGRVLFRPSDMVYSSNQDALLSRSTVKLRKLEPLRR
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MDASSIVFLGAGKCNVVVDLPMRFVPSSLSAASHPTGAATQRAALRIRNAAVKECPECYRALEPYAGRRRAVPLPADLYAAIASVVPAKYHALMHNTSEATLVPNFTSDPAQLLQMDMAASDAAGRVADYTVEVKPKSAWQPPQVVGIVADGAARWIEETKQHYCRYAQMLRYKEVRDVAEEAPASVASAAPHGSVRSAKMGCGPYCPSYLFRPALSSREGLQRLMHNPQNNLKVVSYHASRKGTHTGDPKTLTVEELNGIADAIDASRVLAPLAHLQLYGCAPASADASPEETQSRSVPVLDAHLLYHWSVAQNKEDVQWIVVDTDPDVLCSCVSITDEDACKRPSRASPRYVAPTLDYAKCLDRFYVSTTAKDVSLMIAVSCRTSQPAAPASECAVMTDVSPEVDGGCFVRRGAAVYRIGVVDLDAKTHKSLAHYYMHDKDIVNAFVARGSNKGDE
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion.
Sequence:
MIQKVGIIGSGISGLSSYYYLRNGINLTSKFSKNNLKINIFEKSNKVGGNIQTRIIQGKNKDEKIIVEEGPRSLRALGRGLNTLEFIKRLGISNDIIFSSANSNGKFVLLDGKPKEIPMTSLFDIIKFSFKHSIVSSILKEPFKKVPSQVKEMDPNWDESVHDFFSRRLGKTMTKTFIEPTILGIYGGDYTNLSIKSTFKRAALLEPFGGLILGSLFKSKKQKQFELDLDKNEKRLLPSKNELTELFDKDTDKTNVFSFKENGLSRMIQKLKSLIESDSLTKLYLSTSIVEIEKDVTNGTLKVTDNKGNQYQYDQLISTIPLNQLAPMFKKSDSKLYQLLQSVNYTSIAVINLIYKSNKNVVKIISDKGFGYLVPSKENQSVIGVCFDSNTFPEFVNNNNNNNNDNDNGNEKDQSIITVMIGGNNGIKDRNDNWIDVTNTSKDKLLDIALKHLDKVLDIESSPDFTNVSIYDNGIPHYNIGHQNLINEIQNHITKNYGTTLLLGGNSIDGVGINDSIHKSKQLINSLKLSNN
The following text describes a protein:
Function:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis. May play a role in promoting fertility.
Subcellular Localization:
Cell projection, microvillus membrane. Apical cell membrane. Note=Co-localizes with aat-6 at the apical cell membrane of intestinal cells.
Domain:
The PDZ 2 domain is required for the interaction with the amino acid transporter protein aat-6.
Sequence:
MVHIPSDVTPPRLCVVEKLNGENEYGYNLHAEKGRGQFVGTVDPDSPAERGGLITGDRIFAVNGHSIIGENHKKVVERIKANPNRCEMLVISEEGAKWYNENNVQITLDLPNIERVSPMSKETPVFVPPPPPPTDAMPYLPRLAELNKGTPDQEFGFNLHAERGRGHFIGTVDAGGIGEKAGLEAGQRIVGVNGQLIYPTTGHKEVVALIKKDTMKTTLLVASEDVDKYHKDHNIAYSWDNVERVDTRPVINVETHHHHEEVSVPKSNGYDVPPLNPHSIQVNEEREISKMTTTTRTETITNSNSAYQYKESSTAYDAYATPPVDSNDLMDEVFGRVNLPGVTMSSHTEVLPPTDDISSVSSLSSHRESAVDVPVSHQYVPSYATESHQKHEQHSQTHHHHHQHQQPSPLSNGSSHGYAASSTSGYDDDDIYHLSAREARERLRMKNRKHHLHEMSLNEKYQLVSNM
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MENNNNNNNNNNNNNNNNNNIVLLKCVSQNYEWGKYGSNSTVAKLLKGYAKECSDIIKETIPYAELWMGDHVSAPSKVEYKNKELKLREYIDTVQKEINEKSSTSSSSSSSIRGEIVEKRFGNDFPFLFKVLSIRTALSIQAHPDSQLAQVLFKKYPNIYKDPYHKPEIAIATTPFEALCSFRPLSEIQSFIDTIPEFKNSLPNNLIKLDDCKEYLKSIVTSLLKADGLLISNNLKELNNRLNEKREEERDDLDRLVLKLYSQYPGDVGVFFAYILNYIVLKPGEALFLGAGEPHAYISGDCVECMAPSDNVVRAGLTPKLKDVDTLGDMLTYRTGRPDLVVPQQRPDLSLTNYRCYQPPVDEFQVEYYHLDDCCKNINVYSSKGPSIVLVYSGNLSIENKSNQSTLNNLHTGSILFVPANTDYQFIQSDSSIPVSIYVASVSNRIFNKNNL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSLEEQRTRDELKHKLLDLNQLHEQLAELRTICPSLLKLLHPETGTSRKFEKSAQEAIEKVNSFYTHLKSSQNVFDYAEKSLQADSSNLLPTYLYNSEDLSNDTENNETKSINGKSALDLKEPHHSELHDNDNFQNSDINIESFKGDIEASGSILTTHENKSFTLKLANELEFIFFHDTRGKFSVYCSSSKDDAITFSINRNNNFLGNLWSLMPKILDYQHLYSKPCDFCKSLISPVYLELPSVRRNANSTVKPTSKDILALHAECVPAQSDL