lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MMASLRHSITSALRSSRQGCSKSAQWQSLDQQFGALRISSRSLSTHAHDHNPNVDGQFIAAPALSIDNFKLHPYARAVPVSPSYFTRTPRFYDNYLSLEKLMEEYEDLPVIPATAVERVAWKTLEDIRKELGEQVKASEFARCLALVKRLNSIHPDLKPQEIKDVLDSFRRNVQPFTNVAKPIPIDQFGRACGVGKRKASSARAFVVEGTGEVLVNGKTLAEYFGRVHDRESAVWALRATNRIDKYNVWVKVEGGGTTGQAEAITLAIAKALLAHEPALKPALRRAGCVTRDPRKVERKKHGHVKARKMPTWVKR
The following text describes a protein:
Function:
Transcription factor that induces gliogenesis. It determines the choice between glial and neuronal fates. Also has a role in the differentiation of the plasmatocyte/macrophage lineage of hemocytes.
Subcellular Localization:
Nucleus.
Sequence:
MVLNGMPITMPVPMPVPMPVPSPPATKSRVAIDWDINDSKMPSVGEFDDFNDWSNGHCRLIYSVQSDEARKHASGWAMRNTNNHNVNILKKSCLGVLLCSAKCKLPNGASVHLRPAICDKARRKQQGKQCPNRNCNGRLEIQACRGHCGYPVTHFWRRDGNGIYFQAKGTHDHPRPEAKGSTEARRLLAGGRRVRSLAVMLARESALSDKLSSLRPTKRQAKTQSIQESKRRRMGASDVLETKQELVVPPTTYLPTSTPTHSTNFNQSQGSYVPAGQGSVISQWNREIHYETEDPCYANGMYSYDMLHSPLSAHSSTGSYYQENKPQQLQHSQYQQQLSPQQHVPVSYDPSQPISSSLQCGMPSYEICDDTSSLTSSSGYCSEDYGYYNGYLPNSLDVSNGSQSQNLSQDASFYTTSSEIFSVFESTLNGGGTSGVDLIYDEATAYQQHQQQGTFPHLTNYQQEPQDQMQSADYYYSNTGVDNSWNIQMDATYHPVNSTDPIYC
The following text describes a protein:
Function:
Does not exhibit any ribonuclease activity.
Subcellular Localization:
Secreted.
Sequence:
MSAGKMMRTLITIHPLPLLLLLQQLLQPVQFQEVDTDFDFPEEDKKEEFEEYSEQFFSIGPTRPPTKEKVKRRVLIEPGMPLNHIEYCNHEIMGKNVYYKHRCVAEHYFLLMQYDELQKICYNRFVPCKNGIRKCNRSKGLVEGVYCNLTEAFEIPACKYESLYRKGYVLITCSWQNEMQKLIPHTINDLVEPPEHRSFLSEDGVFVIPP
The following text describes a protein:
Function:
May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MENSHNESEEQPQSTPKVEEEQPAVEQSPENQCSEDDQSSEDLSSEEQSSDEEFFPEELLPELLPEMLLCEDRPPQECLPQKNAFEDRIPMEQPPCGIGKHKLEEGSFKERLARSRPQFRGDIHGRNLSNEEMIRAADELEEMKRVRNKLMIMHWKAKRSRPYPI
The following text describes a protein:
Function:
Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso-Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc-anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross-linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks; LcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLFHLIAPSGYCIKQHAALRGIQRLTDAGHQVNNVEVIARRCERFAGTETERLEDLNSLARLTTPNTIVLAVRGGYGASRLLADIDWQALVARQQHDPLLICGHSDFTAIQCGLLAHGNVITFSGPMLVANFGADELNAFTEHHFWLALRNETFTIEWQGEGPTCRAEGTLWGGNLAMLISLIGTPWMPKIENGILVLEDINEHPFRVERMLLQLYHAGILPRQKAIILGSFSGSTPNDYDAGYNLESVYAFLRSRLSIPLITGLDFGHEQRTVTLPLGAHAILNNTREGTQLTISGHPVLKM
The following text describes a protein:
Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPESSRPHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHTSAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
The following text describes a protein:
Function:
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume.
Sequence:
MDQDPRKDNPVEMDVDRDDSSQDPDDNESFKSALDEPLDLKELYQDALEKPSEEPSEELNDQVSTPAALTARAYQLEMFEASLKQNIIVALFSDRVMVADGHWQWQDSGRIWFLTPTVALARQQHRVLQSQIPSVKAIMLCGQDGVDSWSEQAVWDAVLLNVRIVVSTYQILFDANAHSFVRLDSLSLIVIDEAHNCSGSHPIARLMTEAYLPAKKAGLPVPSILGLTASPLKSNNLADIEKLEQVLDAVCRTPTIHREELLAHVNRPEMLVVSYGDSGTDPTPTDLMTRFLEAYHRLDISKDPDVLLLKAQRTERAREKLRQMITKKDTLAQKELRGVYNRALLVRREIGPWAADYYLTRTVSHMLAELERGEPPAQHRYIGEALRSIPIPAISKEPIQLSPKVQTLLKVLASHQQDPVGIVFVKERVMVSIVTHIISTHPLTKDRYRTASMIGTASVPGKARNHMDMTKKEDMTSLEGFRLGRFNLLVATSVLEEGIDVPICNLVICFDEPSNIKSFIQRRGRAREVSSTLYLMVQNASSESATDWHNLERLMKERYEDEMRQNAELELLDDPRIGSYPVLEVESTGARMTIRDARSHLNHFCAKVSSRSRYLQKEPYFVIRQVNPDPASPGRRTLLQATVHLPASLAPDLRRHESLWTWTSEKLAIMDASFQAYKALYNAGLVNENLLPTKVSDFLADLGDDPGHIWVKTQFDPWPEVAYAWQESSSLYSRRLTVLVPGVENPLEFEFILPVPVPYMAPLKLWWNATSALTLITSPEMQEFRKQEGTSAGPDHSYALLAMAFAHRFPIQGRQYPIRLVSTRRKLDVDGIAALEFDPRLYESSPQPPLVRLVDGRNMPYFVTKILPSKPPVELISKPSTDHADLPENVPYVVCKPIGKAVGQFIPLDAAQDQDSWTPKNGKLYRKVLPSTQIRMDNFPAVFAQVGAVIPAFTRAVEMSLVAADLMYNRLGCLQLDNLPLITTALISSGSRGPTNYERLEFIGDTILKFCACLTASALFPNHHERLLSQWKDKLVNNVRLCRASRDFGLDEYIINSAASKKWRPKFVEDYMDEMKSPISAETRQMSSKMVADVVESLIGAAYMCGGMSKALECVALLLPTPKSSQFKWQEIELSRTQLFEFAPKDAILSKQLEPLEKAMDYTFNKKSLLIEAMTHPSCAGLGTNESCYERLEFLGDAILDVIVVKRLMAETGPNELAHNDMHEHLSSVVTADIMAFLAMEWVIMQTDINEIDPTNLDALGLLPSSQSRITPASLVSNKEDWPFWRFMRHNSPQVGATQTATIERYLTLRDEIRDAIWKHNTLPWALLARMGPQKFYSDIVESLIGAVWVDSGSWKACEDVLTQMGLLPLLDHLLETKAHVMHPNVELQILAPPNKRATRTEFVIISNKRGIISSGTEFLDEPSAVDDGLVSVEPYDDTPEHDEVFSCKLFVGGKQVADVTGAATKEEARVRAAEKGCLVIKAERKVWNEAKAAAKEDKGHNTENGDANADNGQSGEKEEVPDCRDADGDTVMN
The following text describes a protein:
Function:
Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway (By similarity). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus envelope. Cell membrane; Single-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region.
Sequence:
MASRESGGSRAAALLLVLGVERALALPEICTLCPGGMHNLSRVAAYCEDTSKLMQARCCLNQKGTILGLDLQNCSLKDPGPNFLQAYTAIIIDLQANPLKDDLANTFRGFTQLQTLILPQDVPCPGGSNAWDNVTSFKDKQICQGQRDLCNSTGSPEMCPENGSCASDGPGLLQCVCADGFHGYKCMRQGSFSLLMFFGILGSTTLAISILLWGTQRRKAKAS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate. Involved, together with the calcineurin ppb1, in cytokinesis.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Also localizes to the cell division site.
Sequence:
MKIDSNGIVNPHSITNEIPSYDEKQAVDLNGNAFAPNGTFQKKDLISHKNDFERTMRHDVLHTNPKIEVRSETHIYEPNDSLFKENQDFPSNPTAHSPSSSSNDSVITATGVPDGILRDSPIVSALEPPSSNSSSSPQLQNLKHQLSSPQPSRAPIDRSSSNPVTSSQQPPNDRSTLSSSQKAKRPLKRSYSEKNSSNAEPSGSRSGDRGTNVSTSGSLLDGIPPDIGSASWAEAVKQKRVNMRRRREELDDECVLVGTRVSEGHENYVTAYNMLTGIRVGVSRCQAKMDRELTPADFTARHKFTFDITGNELTPSAKYDFKFKDYAPWVFRHLRQLFHLDAADYLVSLTSKYILSELDSPGKSGSFFYFSRDYRFIIKTIHHSEHKFLREILYDYYEHVKNNPNTLISQFYGLHRVKLPFGRKIHFVVMNNLFPPHRDIHQTFDLKGSTLGRELDENQPCQSPMCTMKDTNWIRRNMHLQFGPLKRQIFLTQVKADIDMLSSLGIMDYSLLVGIHDLSRGNRDKIRNSILSVYDPNVSQHRVPSINGNESHSNVHVIRQVVNSTGPVSLDQSCNLLPTDQFVERRNFMFYSDDGGFQATDENNEPGNFIFYIGIIDLLTKYSYVKRVEHLWKGINHSDSVISAVPPAEYASRFYKFVESSIKPTLLVLKPFPLKPQDGQRVNKQQSVNAGNVRTNNKHGSLNNNTAPSSRNAKSTSAHKSPKTEHRFPFPCRNVTTNTSSS
The following text describes a protein:
Function:
Required for vacuolar protein sorting.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Sequence:
MSRHHRPFTWGGAQPGASFSNPTSPTLEASTFGFEPSVPDIYRRAWILVTKDASAELFADTSDADIHLGLLHKLLTSAGGLGPGSAEQIVNSACKGSRCSRSDFYCALGLLHQMQQGEELDVHLVQQRLTMGSLSAPVLDLSDATLNPHSHHTFPPTAPSGPSRIDPRPSTFMREMSDPWNANSSGSYNGIDTRPAYNQYDAMPQQYDTLNSHDSALPAGFAGNVSSGSFERIKFNAGDDRRSHQLLAHNQGSSTDTFLAPDRTEARARQPNTRQERPFSYMSDTAETNAVDAAEDPAADLPEDQVTVRLRSELEGFIIKHNVYIVSSSLRKSQVTRRYSDWLWLAECLVKRYPFRCLPVLPPKRIAMPIAGRHLSADDLFIERRRRGLERFLRMLTCHPMLREDKLVEVFFTEPRPIAEWKSSAPALFLDEEGLIKTVDEAERMSIPEDLQLKLTQQRQAIPELLERWTAMVALFERIVKRNDAAAADYSRLNFSLLSVIETSARRWRPGSDNGKKTEEIMSTMASIFQDHSDTTSSRVSAVSLSTLEGMKAQRDLILSFRDLIGRIDRQLVDPIDMLKKRIEASQKRITTLAASANSNSASIQQEQATLSAQVKQDTQSIQKYLNRRIHAKKTVWEELIWFHHRFKAVEEDMQKFVRDETFFLSTLTRMWEATEMKMKMIR
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MISIYDLPEYLHSFDLCVASFAMFFNCFLIYLILTKSPAQLGVYRYLMVFISVFEVLYCILEVCLVPIHYSYRSSVVVLIRTSDKIFNRQTLLFLDAFYWGFFGSSLSIFAIHFVYRYLVISGNPLLRTFQSWKFILWLLIPIVVGFMWAFTGIVLCAPTEEFTEFMRKPIKEVFDEDIEEFEYLGAFMYERSSKNNSFLVYWGPIAGMIIMCLTVFASFIVIVVSGIKCYLRIKQLISNVSTTSSRCQALQSQLFHALVVQTLIPMILLHTPVTLKFAFAIFDAGLGPYCFFMSMTIALYPAIDPLPNFFLISPYRKAIKKILKFYLLGKKPKPNAAEQVNQTSMT
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Sequence:
MGQINSSFRPLDADGPSTFPFYFASAPLGVAVVRWSRLSASQARRKRLSGLRFIGLSCASCFLFYQGPANMGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGAV
The following text describes a protein:
Function:
Binds inorganic phosphate with a Kd of 1.2 uM. Part of the ABC transporter complex PstSACB involved in phosphate import (Probable).
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MKKVIILIFMLSTSLLYNCKNQDNEKIVSIGGSTTVSPILDEMILRYNKINNNTKVTYDAQGSSVGINGLFNKIYKIAISSRDLTKEEIEQGAKETVFAYDALIFITSPEIKITNITEENLAKILNGEIQNWKQVGGPDAKINFINRDSSSGSYSSIKDLLLNKIFKTHEEAQFRQDGIVVKSNGEVIEKTSLTPHSIGYIGLGYAKNSIEKGLNILSVNSTYPTKETINSNKYTIKRNLIIVTNNKYEDKSVTQFIDFMTSSTGQDIVEEQGFLGIKT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MMIMYESLYQKLTTFCPSSSLLAVVASSPKLKSSSFHLRSSLFPPLKRRMATATYPPPPPYYRLYKDYSENPSSAPQPPPPIEGTYVCFGGNYTTEDVLPSLEEQGVPQLYPKDSNVDYKKELRSLNRELQLHILELADVLVGRPSQYAKRIGDISSIFKNLHHLLNSLRPHQARATLIHIMELQIQQRKQAVEDIKRRREEAQRLLKDAFVTLDGQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol. 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols. Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts. In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs).
Sequence:
RARSPIPGMLRCARAWRLPHRGIGPSSPSFSRVPVALSSSQGGTEPRPVPLSYKLLDGEVARPPLVFLHGLFGSKANFSSIAKALAQQTGRRVLTVDARNHGDSPHSPDMSYEAMSQDLQDLLPQLGLVPCVLIGHSMGGKTAMLLALQRPELVERLIAVDISPVESTSSSNFPNYVAAMKAIDLPNGASLSSARKLASEKLSSVIQSISVRQFLLTNLVEVDGHFVWRVNLDALSQHWDKILNFPPRQESYSGPALFLIGGNSQFVLPSHHPEIRRLFPRAQMQTLPNAGHLVHSDSPQDFMAAIRSFLA
The following text describes a protein:
Function:
Positive regulator for glucitol operon expression.
Sequence:
MVSALITVAVIAWCAQLALGGWQISRFNRAFDTLCQQGRVGVGRSSGRFKPRVVVAIALDDQQRIVDTLFMKGLTVFARPQKIPAITGMHAGDLQPDVIFPHDPLSQNALSLALKLKRG
The following text describes a protein:
Function:
Plays a role in the formation of tricellular tight junctions and of epithelial barriers. Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, tight junction. Note=Found at tricellular contacts.
Sequence:
MSSSDARSRIRDRGYSEVPRDTSCPDGTIRTFQSLHSSELAVSADPLPPPPLPLQPPFGPSFYSSDTEEPAVAPDLKPVRRFVPDSWKNFFRGKKKDPEWDNPVSDIRYISDGVECSPPASPARANHHPYKDPSRGSQGTFNSQHEADAMFAHDPYASLDRRTQTARTYSEKVEEYNLRYAYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDNEWYNLFGYTQPYGMGGLGSLGNTYGGYYYSGPKTPFVLVVAGLAWITTIIILVLGMSMYYRTILLDSNWWPLTEFGVNVALFILYMAAAIVYVNDTNRGGLCYYPLFNTPMNAMFCRVEGGQIAAMIFLFVTMIVYLVSALVCLKLWRHEAARRHREFLEQQEINDPSLSSKRKMCEAAISDRQRDQEVNVKDLRTTTKMTPELLSGHIPPGHIPKPIVMPDYVAKYPVIQTDDDRERYKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSENRQEHERISRIHEEFRKKKNDPSFLEKKERCDYLKNKLSHIKQRIQEYDKVMNWDTQGYP
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MPKQRPSPTKLPTKKGDCSQWVMVVPESVTDLPKKPNSGPLFTRLCNPSTGQAALYLFSSDSRQLFELKAFHEEYRSWFIGQAVQQDGRLFFATPMDPLFLVLVYLIKSEKEHGKFQPLDQILVDEEFPSCSMLLQCTSTSRTIHHIVEEKEIGGKKFYKFSEEKTLKWLKKKVDQTVKVLKCHDVRVDARVQTATFISGKQFTDATEDDYIRYAHGLISEYINEDLSTALAKYLRSLSESCAFTLVIPWEESSIFPITQWRLKIDADSRLPQISSPPAEPASKKRKLSDAPVEAEEDYTKFNASDLKNKKANSKMSAAQKALSKVDKSGMKAISSFFGSKNKAAK
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNGKGIWMRLELTITDYGCNLAMDAPVERSSCSITPSLLMESGRGREGDWLERLLRRLDYGFNLQSVNTLVSQRSSQTQPGEEKKRRGARRGEKETTGEDNESTTAHVMTRERGAETVTVPRVSLAKQWKRLSVFHHSRATPETMLRAATRSTVRQSGARLQSSTPTPTPRPTKKSGGGGKKLLATTATIAAAGGGVIGYAYVDPEFRHKVESTIPQSKQVFDSILGQSSLEKTKKSIEDTKNRVIDAIPKRKQTDVIPPLPLEKLPPIEKKAPVHVDPVDVKPPVITEKKLSEEQAKKINAQLEERLMAALAAAERKVQSLTEAKMNTIQAIRKHADTLKQTVDAGQKGDWASVNAALAETEIQAKKDAGAEMDGKNYIDTLKKVINDGKANINSRSNPLLINAMETANKLSHQVDELNVLVNRARQEAQVFTQYKDLIDRSRQQFAQELKSIVPNVDVNAKDKNLNEDELNALIAHAHLRVDQLRRQLAEQQIREEEHIGKAIESQKRADEEASAERLALELKRLRDTTAVEVEKEVGRNRSTWEVETEEKLTRASAAHSEHLEKVVRTQRQLFEIEHNQKVEEAVRNERDLHSRHVGAALSRLEGIESALGSRVALDAENRRSKQFWIACHNLIQSIVHGEKAGKDMENRRAPLGQQLEILKQVNGEDSFVDSVISVIPEQAKKTGTIGKYAWSYVRSLFLVDLPRRFSYDDKIDPVSIDNLEVLARAKYFIERDDLESAAKILNLLTGEASILAVDWVKDTRAHLETKFIAEILVAHAAVQSIRSTY
The following text describes a protein:
Function:
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MCSLALSGSLAFWLSASAPVSVSVSLPLSLCLSLSLSVYLSLSLSLLSLSLCLSLSLCLSLCVCVWIVVHWSALSWVHEACLCPCASTAIMEAVLELLGFQKDVFGEVRRMNKRQLAHQVLNFAMIVFSALMIWKGLMVVTGSESPIVVVLSGSMEPAFQRGDLLFLTYNRTDPIRVGEIVVFKVEGRDIPIVHRVLKLHEECVDLSLVSRAVQPTMIFPYPLLTFAFASASASASYCPSLSKQGNIKFLTKGDNNRVDDRGLYAQGQLWLKPKDVVGRARGFIPYVGIVTILMNDYPALKFILLATLGAYVLLHKE
The following text describes a protein:
Function:
Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.
Subcellular Localization:
Secreted.
Sequence:
MKLPSPWLLAILFIVSLHTVAGGEKPSACQCSRMDPKNRKNCGFPGISSEQCFASGCCFDTQVPGVPWCFTPLPKQASEECVMEVKARVNCGYPGIPLETCKERGCCFDDHIPQVPWCFRPIPVNDCHY
The following text describes a protein:
Function:
Potassium channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The six transmembrane regions are tightly packed within each subunit without undergoing domain swapping. Transmembranes TM1-TM3 are positioned on the inner circle of the channel tetramer and participate in inter-subunit interactions that are central to the assembly of the ion conduction pore. The RxxxFSD motif within transmembrane TM1 coordinates a network of specific inter- and intra-subunit interactions with other conserved residues on TM2 and TM3 and plays a key role in the tetrameric assembly of the channel. Transmembrane TM4-TM6 are positioned on the periphery of the channel and do not contribute to contacts with neighboring subunits. Transmembranes TM1 and TM2 are linked by an extended strand-like tail and two short helices (H1 and H2) which protrude outwards from the main body of the transmembrane domain and enclose the external open entrance of the ion conduction pore in the channel tetramer. Transmembrane TM1 forms the pore-lining inner helix at the center of the channel, creating an hourglass-shaped ion permeation pathway in the channel tetramer. Three hydrophobic residues on the C-terminal half of the TM1 helix form a bottleneck along the ion conduction pathway and serve as the selectivity filter of the channel. Ile-16 is probably responsible for channel selectivity.
Sequence:
MTKGRLEAFSDGVLAIIITIMVLELKVPEGSSWASLQPILPRFLAYIFSFIYVGIYWNNHHHLFQTVKKVNGSILWANLHLLFWLSLMPIATEWIGTSHFAQNPVATYGIGLIMSAIAYTILENVIIRCEGENSKLKEAIHSKFKEYISIIFYVLGIATSFFYPYIAIGFYYLVALIWLIPDKRIEKSLKEN
The following text describes a protein:
Function:
Confers tolerance to lead ions (Pb) stress mediated by Pb(NO(3))(2) probably by promoting Pb accumulation leading to subsequent glutathione-dependent phytochelatin (PC) synthesis and related gene expression, including PDR12/ABCG40, GSH1, GSH2, GR1, GR2, PCS1 and PCS2.
Subcellular Localization:
Cytoplasm.
Sequence:
MGLLSNRIDRSSLKPGDHIYSWRTAYIYAHHGIYVGDDRVIHFTRRGQEVGTGTVLDLILVSSGPSRNHTHCPTCVPPNEGHGVVSSCLNCFLAGGVLYRFEYSVNAAHFLVKARGGTCTLAVADPNEIVVHRAKHLLQNGFGCYDVFKNNCEDFAIYCKTALLVLEGRTMGQSGQAVSIIGGPIAAVLSTPMRLLTTNVYGMAATAIGVYCASRYATDIGMRADVAKVEAEDLTRRLSSGLFQVLDPPLAAIALPSTS
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
Sequence:
MPKRILVVEDDFDIHTIISEVLKESGYLVEVATDGLIAVEMFRRGNFDLIILDVMLPKIDGFVVCEIIRKESSMPIIMLTALGEEEDEMKGFELKVDDYITKPFSINLLIKRVEAVLRRANGLEENNSTLTFEEITIYPSNYKTLVNNKEIELTYKEFQILEILISNVGRVFSRESLLNQIWGYDYFGDTRVIDTHIKNLRQKLNIDYIKTIRGVGYKIEK
The following text describes a protein:
Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
Subcellular Localization:
Secreted.
Sequence:
MKATIATAALLVLALGLTSEAVQVEENGLSFSLEAVSRLQELAESRAMTGQQSPRLKASTYSLCADPMLPQEFLPLCKQRASQSSLLRLAAVPRDLCEICAFAACTGC
The following text describes a protein:
Function:
Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles.
Subcellular Localization:
Cytoplasm.
Domain:
The Asp-Pro-Phe (DPF) motifs, which are found in many presynatic proteins, are thought to mediate an interaction with Alpha-adaptin.
Sequence:
MSWRDRDFDPHGGRNAFRLTDESKQSSSERAASMRAMRSFTQSIEDEGPPELPASLDIDMIEGVSMKTSDTNDTIIEVKPGKVDPQLGETQKYKMAVPGPGHSEQEQELHKSLIRDEEEDAEVEQVFAASAEPVVTPPKSLNFAETAEELRHAYDQKIRKRPTTPTSACVLDGIAFFAGSVDGSNDTIPTDAEKKIKVSIPSGRRRKTENMSYSEFYESMANQIPGGGGRRMSQSGRTTPLHDYEGDILDENPQYKDKAPPAPVVHRRSSIEWENFADMEDKMEQAEEKARKEEKKEKEETAEVAQNDDVTTEKHQNEVEKSKKMLNFLAKPPTVEITSPDAPHQGAFHDNTPKEPKVVEEEEDDDLPTFSEDMDEARQQVMKEMTESVVKTENVENEKQEDTHISEGHVEYGTEESPAVTDGSYQQDGTENAYDPNAYPGYIWNYETQEWEYDPSYVAPEEPIDQSAYEAQAAAYAEVDQRAAEVVYQREHAGYDQGDFYTHQDTSYSSEAYAHDQAKGYQDPNAYGAEAAADNSQEYDYSAYGGYEGYLAACRAYDEESQQPQYGETVATEAYSQDYGYEQQGDYHHEGVGATDENSTSAISGYEQNGASTSLGYGDAQGYDGYDHNASYYQGQEYQQEYYQNHKYENSQYQVDQHPAESAAPPRPVAPMEPLFKQAPPQPDPFGWDSSGHTGDAPTASEPVQELSPTPEASSSTGTSAPARPPPARPEAPKKDETAVDAAAPPRPPPAARPPPPRPAPANKEKPKEPEPEEDAWAQFKRMTEKVSTAVKSTESTLKNLEETSAANDIKDESYLANVGGSQGFVNESTQKEIQRLTEEKKMEKLQKKKLKQQGKKAATPTLEPDEEDAMDRAAQELAMKMASMRSDMADWKAPEMIPVKEIKKAPEIRRVDSASAIPPRKRSSIKDVQQDSGGSLELPPHLAAPQDSIAPNPKGDHAPDDPILSAPAWADFETSEPMLPPSESGFFSNKDASNEGGVSRDATDDPFVTTVASSEKRSSFVADPFAPQQAALIDESYDPFAVVAVEEVVAMAKAKAEQAAANAENEDDFYNGRQSPTLSTPTPEGGSPISQQRPNAFEDDFKCAELTGLDTPTPLYDEDDSQPLTDFIPKFDGDGWDLMVRHPIKKKSFMAERCWKPCYVRLHGLTLYLYNDKKDAQPIQELLLQATYSLSDTTLQAYDVYGKIHTVKLQFVVYKEKVGIRPGQISRLVDGHITKYGLPLEHSAQCTVLLKFGSLNASHLQTFVTTVEDLLFKCKITRTAKPVYKQDEVQIHCYDEYSAFVDKEGILSDQKARVRLFCLAFLTGSPVLEVGLNDRRRQGKEIVRRKDILPMYTERWIRFEALEFHSIVNKPEFDKEQVIAFSPPDGCFFEIMRFRVRPPRNREKAMTVKSIMKIAGSKVEIRIEAMAAAQIQRTRGSDERRNIPCEDIAIRFPIPEAWIYLFREERHWGVGSIHSKKLRPGKVKNLKDRLLGAVQASEPNLIECAIGEAKYEHVYRSLVWRIPRLPEKHHAAYKSHLLKCRFELSSFDLMPEEFLPRCDVDFTMPLATVSNTVVRSVSVEQHEDSDRVEKFVRYVAKYQYKVEIDYVQCADLDLDMADPSVNPEAAAAPVPELHQPTFNPSTQESDTQQGYRIDFNEAEMGGSNRRDDSSSDEEPDSHKMPIIQIDMKNYGY
The following text describes a protein:
Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Miscellaneous:
MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQAALTAFFMLLFSLLSLLGIAANGFIVLVLGREWLRYGRLLPLDMILISLGASRFCLQLVGTVHNFYYSAQKVEYSGGLGRQFFHLHWHFLNSATFWFCSWLSVLFCVKIANITHPTFLWLKWRFPGWVPWLLLGSVLISFIITLLFFWVNYPAYQEFLIRKFSVNMTYKWNTRIETYYFPSLKLVIWSIPFSVFLVSIMLLINSLRRHTQRMQHNGHSLQDPSTQAHTRALKSLISFLILYALSFLSLIIDATKFISMQNDFYWPWQIAVYLCISVHPFILIFSNLKLRSVFSQLLLLARGFWVA