lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP.
Subcellular Localization:
Host nucleus. Note=Accumulates in infected cells.
Domain:
The C-terminal arm bridges DBP molecules together, thereby creating a chain.
Sequence:
MASNQHSQRERTPDRSAQPPPPKMGRYFLDSESEEELEAVPLPPKKKVKKSMAAIPLSPESAEEEEAEPPRAVLGVMGFSMPPVRIMHHADGSQSFQKMETRQVHVLKASAQNSDENEKNVVVVRNPASQPLVSAWEKGMEAMAMLMEKYHVDHDERATFRFLPDQGSVYKKICTTWLNEEKRGLQLTFSSQKTFQELMGRFLQGYMQAYAGVQQNSWEPTGCCVWEHKCTEREGELRCLHGMEMVRKEHLVEMDVTSESGQRALKENPSKAKVAQNRWGRNVVQIKNDDARCCFHDVGCGNNSFSGKSCGLFYSEGMKAQIAFRQIEAFMLADYPHMRHGQKRLLMPVRCECLNKQDGLPRMGRQLCKITPFNLSNVDNIDINEVTDPGALASIKYPCLLVFQCANPVYRNARGNAGPNCDFKISAPDVMGALQLVRQLWGENFDGSPPRLVIPEFKWHQRLQYRNISLPTNHGDCREEPFDF
The following text describes a protein:
Function:
With ARX1, involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.
Miscellaneous:
MISCELLANEOUS: Present with 4780 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPSKNSINRPKLTSNLHHKVHSLNKKRAQRERAGLLKPARSSVNSKSGEIKSVALDLYFQNKKNESQNSTAVTLQNASSSPASITTRTLSKKRAKKIERNLKYATQRKLLVDASAKLEDEMDIDLDGGKKVKENEKKSSLTLVKEALWSVIDDTASQGLIIENGQGTTLGGPFFP
The following text describes a protein:
Function:
Binds F-actin and nucleates actin assembly. Major high affinity link between the plasma membrane and the cortical actin network.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Note=Preferentially localized in some actin-rich membrane structures. Must span the plasma membrane, probably via beta-strands.
Sequence:
MLVLRNLLALVTLALLFTLSSAQYTLSVSNSASGSKCTTAVSAKLNACNTGCLNSFNIVESSNGKGLVFKTFINAACSGEYESLSQFTCAANQKIPTTSYIVSCNSTPSSNSTTDSDSSSGSTVMIGLASSLLFAFATLLALF
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MKLSLFGKKDSSKQISSDAHEAKKTCGICFDTKTDSDIFNIRSTILKRRKCNHLFCVDCICKYVEVQINDNAYKVLCPSPNCFVKYKPKHLKHILPKQLIVKWEFLASELSKPSEPKTYCPYANCSVLLGKENDIGREFNSSSRCPSCHRQFCAKCKVPWHAGMNCQKFQQFKRNDKNDLDKKFLVLAKEQQWKRCPNCFMYVKKSAGCSLMKCRCGCKFCYKCGKKRSFTSAHTCK
The following text describes a protein:
Function:
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.
Miscellaneous:
MISCELLANEOUS: Structure 4HLU is probably in the open state.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MKITLNSVSFRYNGDYVLKDVNAEFETGKIYVVVGKNGSGKTTLLKILAGLLEAEGEIFLDGSPADPFLLRKNVGYVFQNPSSQIIGATVEEDVAFSLEIMGLDESEMRKRIKKVLELVGLSGLEKEDPLNLSGGQKQRLAIASMLARDTRFLALDEPVSMLDPPSQREIFQVLESLKNEGKGIILVTHELEYLDDMDFILHISNGTIDFCGSWEEFVEREFDDVEIPFKWKLWKKCGKINLWEDRYENSGNQRRRDTV
The following text describes a protein:
Function:
Involved in nuclear mRNA splicing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDPQTNSHQEVQQPSPKETDSQTPSETLYIRNIEEKIRLTMLKRILEHLFGSYGKVIDVQARKTLRMRGQAFVVFDNLENASRALKDLQGYPLYGKPMMIQYSKSKSDIIVQRESPEEIETRKKDRKNRREMLKRTSALQPAAPKPTHKKPVPKRNVGAERKSTINEDLLPPNKVLLLQNIPQEVNADVLTQIFEAFSGFQEVRMVPGRRGIAFVEYDSDREATVAKNGTTGMSLSGNQIKVTFARKAS
The following text describes a protein:
Function:
Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.
Subcellular Localization:
Mitochondrion.
Sequence:
MFRTTKRYFCTSFNRRKNVVVIGGGHAGVEAAAAASRLGAKTTLLTKSFDNIGQMSCNPAFGGIGKGTLMREIDALGGVVSGVCDESAIQFHMLNRSNGPAVWSPRAQMDRSVFKKNMQKTISTYRKNLQVREGAAVSINVLTEDDGKQVCDSIVLEDGTAIPASCIVITTGTFLGGQINVGLTQLAAGRYGERPSLPLSKCLSNLGFKMGRLKTGTPPRLSSPINISKMTEQTGDEIPETFSFLNLERDFSPALPQRSCYRTYTTELTHEIVRKNLAFAPHMLAGDILSPRYCPSLEAKVTRFPHKARHLIWLEPEGLDPNSWWYPNGLSNSMPEEIQHNIIRSIPGLENCNIVRPAYGVMYDYVIPTQLKATLETKKIQGLYLAGQINGTTGYEEAAAQGILAGLNAGLSALGREPVDIPRNTALLGVMVDDLITKGVKEPYRVFTSRSEYRLTTRADNADLRLTPLAQSIGLLDDQTHWESFQRTKSLLDFSNKIAKEFILSPQQWSKLGMPIPNDGKYRSAWDLLSFTNLDLFCVISCIPKLKDIPKRVLQRLIIEGKYTYYIKRQGTQNKQLNCRDESTVIPSDFDFDTLHSVSAEELMLLKTIRPATIGQLKRIQGIKPGTIIRLLRHTYYNPAKEAWLRKVYMPMYDMHSSEENQSTNL
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of a 2'-O-methyluridine in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MLANRANRLVLKRLVHLNTSNIIKPICSYRSLASSSKSKTQFTKKPPISEFSIDEILEHFILKKKTIEGKENKDKNTIKVEKVNTKIDRFSSEVIIKEKNKKNNNIEDEDEFGIEEMIAKNNNNNNNPNNNNNNNNTKKVPTFNRFSTEVIVKSNNNNINEFENEEITKNNLNKKAPKFNRSSSGVVINTTSNDNNNDKNNNEFENEEIMLNSGKTNKKASKMDRYSSEVIIKEKNNEEILVNNNNNNNNNTTTTTNNNNNNKASKMERYSSEVIIKEKKDNNNDIEKDDIEKDEIIVNIMNGFEDKDESAVEFLKRHRIEHQVPKSTIYLKEKTMEEDEMVRKRLSVNRDNINFSNNKNRKQIFTKKNHQNGAGILPKGLANNIVKNDWMKRQMTDPYVAMAQKNDLISRAAYKIINIDEQIQLFKPGQIVVDLGAAPGGWSKYIQERVTNRGLVISVDTSSNFQLDKDCFIHGDFTLTETQNKIFELTKFKSLNDLKLYKHSLIHSDSKIQNLIENGGANGNGSGNGDLQKQPIDNMFKQKSACYVDVVVSDMAPSYSGLQQVDHSRLIDLQRLALFFAFKTLKKGGTFVCKVSRGGEEKKFFKLLESNFISVKSMKPGASRSESTEIYYIGKNYIGK
The following text describes a protein:
Function:
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Sequence:
MPFPFGKSHKSPADIVKNLKESMAVLEKQDISDKKAEKATEEVSKNLVAMKEILYGTNEKEPQTEAVAQLAQELYNSGLLSTLVADLQLIDFEGKKDVAQIFNNILRRQIGTRTPTVEYICTQQNILFMLLKGYESPEIALNCGIMLRECIRHEPLAKIILWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYDRFFSEYEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQTKLIEFLSKFQNDRTEDEQFNDEKTYLVKQIRDLKRPAQQEA
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MSILLEKIIKSSEFNTLEKVINSKNRLKIFGIYKGIYPLFLLYLKRYEKPVLWITNNEEDLNIWEDLQEDLEISILPSYVHLPYERPLRSPQIQGKRLRAISNIIYDKNFSIIASLKSLIYPIIPKDVLKERIIKIRIGEEIAREKIEKYLAENFYQRLPQVEKIGDYSIRGGILDIFSPIYENPIRIEFFGDEITSIRFFNLEDKRSIETTKEVFITPISELIANKDEEKYFLKNKELKKYIFSYLPPNTILIFENYDESLALIQKWTEKGLANLEKRRTKENLPEDLYLTNSLLESYTSHYQVLDLNSKDADIAFSIYSPPSYQGTNEFFEKNIKSFVYDGWEVYISSEHQDIVRTRLKNLNVKYLVGEKIREGFLWEKEKILVITDYEIFGKKRKRKVIRYEKGLKPKDLYLLKDGDYVVHVNYGIGIFRGLKKLKVDELEKEFIYIEYANNSFLYVPLEEMHLIQRYVSSSPDPPQISRLESRQWEETKRKVKESAKEIAEELLKIYAQREITKGFAFSPDSPLQEELEASFPYIETEDQIKALREIKKDMESTKPMERVLIGDVGFGKTELALRASFKAVLDGKQVAILVPTTILAYQHWKVFKERLEVFPVNVEILSRLKPKSEQKRIIEKIRKGEIDIIIGTHRILQKDVEFKDLGLIIVDEEHRFGVLQKEAFKKKYPHVDILYLSATPIPRTLSMVLSGIRQFSVLETPPENRLPIQTFVVEYNPEIIQEGIRRELERGGQVYYVCNDIERLEKIREELSKLVPEATYAIAHGKMDDEKLTEVMSNFYDGKIDVLVATTIIESGIDVPNANTLFVENAEHMGLAQLYQLRGRIGRSYKQAYAYFLHAPLKKLSLESIKRLEALKEFSSLGSGLRLALRDLEIRGAGKILGKEQHGHINSVGFYLYLQLLEEAINELKSNKEGSEKNKINCHIIHPFPAIIPEYYISQSSDRIYYYQKLAHLEDINDIEKIKKEMEDIYGPIPDSVENLCLLSQIKFFAEKIGIEKIEISENQVKLTYSKGIERTLNLPKGDYRKKAQFLLQFLKDISNIK
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MPSFKMKTNLNMSSIRETNCLSVCQKSNVISKKSYSHVSVSQQPAEFDKCVQKCQDGCVASSMEIYTQEGDIKNNEAVDLQDLPRDGNSQFLKQLPISVDSGTTGDIESIYNFASNLETIFSPVLEPIEVLSVPNIDDGAGNNNDLYVPGLGPDDSDYNKSSCDYQTCNISDFFISDMIIASLPFGESAVVNDFTDANPFLDYKCAEPSMLFDVAEECMILPFLKDTAKVSDSNDMKSSEEAMIDSDNSGLYLAINQIRSCDQESDLITDSDQAEDFDPQFFIRNLPELSDVVSNFRPSISPKEPCRRKSITLVLDLDETLVHSTLEHCDDADFTFTVFFNMKEHTVYVKQRPHVHTFLERVAEMFEVVIFTASQSIYAAQLLDMLDPDRKLISRRIYRESCIFSDGSYTKDLTVLGVDLAKVAIIDNSPQVFRLQVNNGIPIKSWFSDSSDCALISLLPFLETLVNADDVRPIIAKRFGNKE
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MYLTVFDCICSHLILEYIDQTWTRNPILPQDPYGKAMARFWAKFVDEQVTLIGFRSLVKSEEIDVAIKEAQELITYLEKEITGKMFFGGETIGFLDIVVGSMIPFCLVRGWEGMGIDMIPKEKFPELNRWIEKIKEIEIVRECIPNREKNIEHMMKIVGRIKAASKTP
The following text describes a protein:
Function:
Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity).
Sequence:
MTKRGLGKGLDALLATSSLAREKQQVASLSQSMSAEGELADLSISNLKPGIYQPRKDLSPEALEELAASIQSQGIIQPIVVRHLPTGGYEIIAGERRWRAAKQAGLKQVPCLIKQVEDRGAIAMALIENIQREDLNAMEEAQALERLQNEFNLTHQQVAEVIGKSRTTVTNLLRLNQLSDDVKRLLETKQLEMGHARALLMLEGEQQVEIAQQVAKKQLTVRQTEQLVKKCLSDPSDAKNVSEDLEIQQLSQNLSEKLAAKVSIVRTPNGKSKVTISLDEPHKLELLIAKLQN
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex.
Sequence:
MSTSTLEGLRTSKKGNLIYDKYWLEDGRVEDVVAYCSSPPSVSVDLLTAALSKTQIASPVREEQRESPETRQRRNDSITANDVEVDHNYSRRKALDTSPVELNESSNVERAIFQCEQEWEKIVKERVKERQWQLQEHSKQVQEQAEQNVALKAQQRELKQRAIVQMKRQAQREMDEMREKRLLHQQELQRLHVKRLDAKLKAAVQQREADEMEKRKRAKEQQDFQQSLSRVKSQVDEAAKKIVHLLQSCSHKEHLSKESSKLPIQIQALCTKADSLVHEASEVESFRGSERTMQAVVDQLMLRQEEAIRAIAEAERKFQEEVARKEKEKERLEKERLEKERQEKEKVKAKKSEARPEPTQPQPSSSSTTAVPLESCVSPDALNDYTGLQEKHKVLEESCKGLSKTTDKDVKKYRFDLQKAVNTPINSVSVQSGSHLLDKLHRIKDLLSGLEVQMTNRRVKATQPTGVIYVKDLAAKKLVKQGDEQVSSNHESAFAYAAIAVALWQDIPDMGDLFLYHFYQSSPFLVPYHMTKKDDQTLEEYYKSLGYCYESEGQIEKQDKYLKRMAGFTRLYAAIIATPPLRGQSHPHGVERGWMFISRVLNLEPQPDITATTLFDFLEVCGQALSEAYGKQFFKLLQTIYRNYFPKIEAVTPQGSGGPVMRLKSFLEDCLKRQRVPPPKGFLSSDFWRS
The following text describes a protein:
Function:
Has pro-apoptotic activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDLRRKGWWNVPDYFHSPLVFDMEEDKEDYIFGPHDEYLHTLEVHSNTLIQLERWFTPTGQTRVTVVGPLKARLWVMDMIRKVGSKNNLDQIKGKMMLLQIRDHPLRDRDLELHPESGSSLWITTMNDTTFVEVPHFLRFPLTVAWLFCGFVRILGIHNFADLHW
The following text describes a protein:
Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane. Mitochondrion matrix.
Sequence:
MNQTTETDSMRINLQRTYKDAINALNSLQSNFASIEATKKLGPSVNRNELSINEVHEFTKRLGYTPTDFNKLNIIHITGTKGKGSTCAFTESILKQYPISKIGLYTSPHLKSVRERIRINGQPINQEKFAKYFFEVWDKFTTTKSDPQEWPTLQPCDQVKPMYFKYLTILSFHVFLQEGVDTAIYEVGVGGTYDSTNIIDKPTVTGISALGIDHTFMLGDNIASITENKTGIFKKGVPAFVSKQSEYPETHELIEKRAKQLGVSSLEFVDTEDLPNVKLGLSGEFQKQNAALAIRIANSHLKTIGITQDLPEFNNNDGKIKKLSNEFIKGLENVDWPGRCQIINNNPTGITWYIDGAHTIESINASSTWFKQEQLKLEKPKRRALLFNQQGRENYAELLEKLFNVTYGTGSEPQIKFDDVIFTTNTTWSSGQFNSELISKNTSEDAVKKLEVQNNLSEVWGKLDGGVSKRHVFADIETAVNYLKDLGDEDLQVFVCGSLHLVGGFLVVLDNERD
The following text describes a protein:
Function:
Involved in heme degradation. Catalyzes the degradation of heme to biliverdin, with the release of iron. Forms biliverdin beta and delta. Binds heme with high efficiency.
Sequence:
MDQQVKQERLQGRLEPEIKEFRQERKTLQLATVDAQGRPNVSYAPFVQNQEGYFVLISHIARHARNLEVNPQVSIMMIEDETEAKQLFARKRLTFDAVASMVERDSELWCQVIAQMGERFGEIIDGLSQLQDFMLFRLQPEQGLFVKGFGQAYQVSGDDLVDFVHLEEGHRKISNG
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH); Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Hydrolyzes phospholipids as well as galactolipids. May play a role in disease resistance.
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MASYACRRPCESCRTRAMAGGVVGEPTTPGQRVTVLTIDGGGIRGLIPGTILAFLEDRLQELDGPDARLADYFDCIAGTSTGGLITAMITAPGEEGRPLFAAEDINRFYLDNGPQIFPQKRSSLMSVLASLTRPRYNGKFLHGKIRSMLGETRVCDTLTDVVIPTFDVRLLQPIIFSTYDAKSMPLKNALLSDVCISTSAAPTFLPAHYFQTEDDNGKVREYNLIDGGVAANNPTMVAMTQITKKIMAKDKEELYPVKPSDCGKFLVLSIGTGSTSDQGLYTAKQCSRWGIIRWLRNKGMAPIIDIFMAASSDLVDIHAAVLFQSLHSDGDCYLRIQDNSLRGAAATVDTATPDNMRELVRIGERMLAQRVSKVNVETGRYEEMQGAGTNADALAGFARQLSDERRARFGPRDGAPANGKSRC
The following text describes a protein:
Function:
Required for ciliogenesis and for structural integrity at the ciliary tip.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MKAATSLGYQIISCSSEDSTHPISSIINSSINSTGWQTSPNPRYPVEFVVDLTTVVELETLQFVSHQFKIANRVDLYVAKSDKDFKALGSFNFSNNAHSNYTSRELKSATLNGIKAQFIKIVIPGCHANPNNPTNQVGIVSFNVLGRGGVPKSSVPKSMGSNGLDGDSSDILEQLERQKREAVEKEDFKRAEVLKKQIERLRRAYDQVVVLQQQKKDAIAREDFVTAQKLKAEIDYLLNGSDPTRDQSMQNQPPPRQSINQQSFQYQDQYQNPPQNRTSFNIPEDDLDEQPIQERRRQLPQKTQKLPPKPAPEPEEPPPRRQSRPLEDEIPPAVQRNFGEDRRPKNVDIAAFEANAQEDEPPRRNRHQIEGANPDERPIHPSKEAGASNPSPSGGGGGGGGRDLQKEPDELSGTNKSEAGCLVDIVSERLVACFFSRAWNLKIDGIKEIANRLVGDKTLSASQKGDAFYRYCYIMRHRVVEDHKAVFSASLEGIKLLGEKLGVSQSDFSRGMQQVVPPLQPKIGCSQQILSKQTCKFLRWVVSKGCADCVIPMLIKSSSKPQQWKAPLAQLSTLHKIVLAKEGDYASLGLSLDQIMNFIVPNLESAAKEVRDAAIEFVVTMNILVGTAVERFMEKVNPRIRKEIDEKIKANQEAE
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDEYNTSENSSCDPILAHHLTPVYFIVLIGGLVGVISILFLLVKMNSRSVTTMAVINLVVVHGVFLLTVPFRLAYLIKGTWTFGLPFCKFVSAMLHIHMYLTFLFYVVILVIRYLIFFKRRDKVEFYRKLHAVAASTAMWLLVIVIVVPLVVSQYGNNEEYNEQQCFKFHKELARDYVQVVNYMIIIIVITIALILLGCQAFITLSMVRKFRHSLLSHQEFWAQLKNLFFIGIILICFLPYQFFRMYYLYVVAHSKSCINKVAFYNEILLSTTAISCCDLLLFVFGGSHWVKQKIIDIWNCLLCH
The following text describes a protein:
Function:
Junction-resolving enzyme that selectively binds and cleaves four-way (Holliday) DNA junctions present after viral genomic replication. These intermediates are created during DNA repair, processing of stalled replication forks and homologous genetic recombination. Introduces two nicks on the two non-crossing strands, at 5' sides of the junction. Also participates together with gp6 in the degradation of host chromosome to provide nucleotides for phage DNA synthesis.
Sequence:
MAGYGAKGIRKVGAFRSGLEDKVSKQLESKGIKFEYEEWKVPYVIPASNHTYTPDFLLPNGIFVETKGLWESDDRKKHLLIREQHPELDIRIVFSSSRTKLYKGSPTSYGEFCEKHGIKFADKLIPAEWIKEPKKEVPFDRLKRKGGKK
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
RYAHKAHEAFSKPLLTFCVSPYVGLCCILWLSLCFLAELEGGGKVLASTPADVLFDPNTAHPNLHVSPNKKKVTWLPEPQNVPDNPERFNATYCLLGTPRFTKGKHYWEVEYGGQREWVAGVARESVQRKGFVRMTPKEGIWQMGLWWLRRGEMDSHPPPKHPAKIRISLDYEQGTVTFYLENKVNVQKVSFKGESVRPFFYVGPTVSLGL
The following text describes a protein:
Function:
Potassium-selective channel essential in the virus replication cycle. May be involved in preventing multiple infections (Potential).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLVFSKFLTRTEPFMIHLFILAMFVMIYKFFPGGFENNFSVANPDKKASWIDCIYFGVTTHSTVGFGDILPKTTGAKLCTIAHIVTVFFIVLTL
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Sequence:
MDSTSFLDIVDKGIDKNKPISTRPANEEDIMSSIFNSIPSKSAAETDIMDSIFDTKDIKKKSQQTSNNDDLVVEDEKSDSSEGVEQKVEAIDQPMEEETIEPLKVEEQIADEQICEEKEEQLEQVDDISEPIKVKEEEQKELEVEVEQNIETDSVNAEKEEPTAEVEQNLGEVESTNEKKEEILISNDLLKASEEDNDEEEINTSISESSDSLTMADAPEIQISTNNSNDTVIFIKDNEISTDKNESKVSIEIQTEPNTPNKNSNNNNPNFSMSVSNVYDDVKTSEITIGTIEQEEFEKKVDLVSPLKLEFDKIFFSAIPLEKTPFEVLKMNAFTGVLKYSPLRGIAWKIFLGGLDINKINNWETDYKKQRERYNKLREEHCFDPRNSNSVYDPLSQNDDSPWNKFFKNLDVQKIIKIDLERTHPENEFFQNENVVEMMSRILFLYSKTNGIVSYRQGMHELLAPIIYLYHKEYTEYQKLDESPKGLIDFIYNKEYLEHDTFSTFECLMRFTSDWYAPAPPPSTNLNATSASAAGTTSSTITVGTSPSQSPNNSLNGDSSDLSGSQTTKFNEVVQKCKYIHSVLLKQKDFELYQHLDSIDIEPQIYLLRWIRLLFGREFHFEDVLNIWDAIFAYGEDLVLIDYFCISMLTYIREQLLQSDSVYALKRIYKYPPVEDVYSLVKKALEIKDSNCSIAVMVKSAQPPTSASSIGTKTIAVLNPSLNNSGSFPETSSSGEDSPTSFLPYSSQISSSSTTPIDNLSTKTTPSLNSSNHNNTHINNSNNENKTINNPLTSSPSNNTSPKISHQNSNNNSNNINNNNNINNNIGLNLNNSGNSGIFKANITKSNSSSGFVKSNPKDLFGVRESDLNLFSSSSSSSAPTSLNSSTNISIGQARSTFFSSSSKHKSLQFTKSPIITDSQKLKNVQHHLGYSLNDIIPLLEKGEKYINSNEDNDRENFLLAISKVKEIRDMLVGTLPLPDSITEDKNEDATSLIGDPLKK
The following text describes a protein:
Function:
Determines thylakoid architecture by inducing membrane curvature.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Located almost exclusively at grana margins.
Sequence:
MASLSVSSSSTIIDSRAPPSRLASASASSPSCISLPTLPIQSHTRAAKATAYCRKIVRNVVTRATTEVGEAPATTTEAETTELPEIVKTAQEAWEKVDDKYAIGSLAFAGVVALWGSAGMISAIDRLPLVPGVLELVGIGYTGWFTYKNLVFKPDREALFEKVKSTYKDILGSS
The following text describes a protein:
Function:
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Sequence:
MLPRLLPFLVSISSLSLGFRAHELPSPSSVWFEARFFQHILRWMSIPNQSESTYYEVALKKYGTSVWKDIHICSKAQTLSCDLTTSTLDLYHSSGYRARVRAVDNSQYSNWTITETRFTVDEVILTVDSVTLKVSNGFIYGTIHPPRPNLVPVGDEYEQIFTHHRIYRVCIRKFSEQKNITKTVEQENFTLEVPKGMRKFCVKVMPHVESRINKAEWSEEQCLHVTTEHYFTVTNLSIFFLSILILCGALVCLVLLWYIRHPGKLPAVLVFEKPPDFLLANPRCPETLDDIHILDLEAFPKVSPELKDSDLHGSTDSGFGSGKPSLQTEESQFFLLDSHAQIQETLGKEGSSELQDTCGDNTDSGICLQESSLHSSMGPPWKQQFGYTHQDQDDSDLVQNSPGHPKHTQDGSALGHGCLLEPEVPEEKDQVMVTFQGYQKQTRWKEEAAEPLDGEIPLAEAFDPELGVRLQGDSAWPPVALATGYLKQESQGMASAPPGTPSRQWNQLAEECSLLGVVSCEDLSIESLGFAHELVPLDCGAASSGLLDSLGTNLVTLPLISSLQIEE
The following text describes a protein:
Function:
May be involved in a signaling pathway during male germ cell development or mature sperm function.
Sequence:
MRSSSWRKSDQRVFIEQVRECMNNGYLLSSKKIGSGAFSKVYLAYATRERMKHNPRLSSDLRGKRHTMVAIKIVSMAEAPAEYSRKFLPREILSLNATYKHMNIVQLYETYQNSQRSYLVLELAARGDLLEHINAVSDLRCCPGLEEEEARRLFWQLVSAVAHCHNVGIVHRDLKCENILLDDQGFIKLTDFGFANWVGLKNSLLSTFCGSVAYTAPEILMSKKYNGEQADLWSLGIILHAMVSGKLPFKEHQPHRMLNLIRRGPIFRPGLSPECRDLIRGLLQLHPCERLDLQQVAAHCWMLPAEHMLSSALGAPREQDHSWSTVAPDNTEPDRDTRHARSKGSSSSSGRTSPRRPSLAQLCNTWKPAPEQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MNAIASAKHKSLARSNIDSSAADMDKVSAPLAVLEKLKTLDIHLQSYRQSVESHQNLVLQVQAMKQDLDNRNKSVLMKMKRLHQAHEGLDSVLANARYKQKLMHKANQGSIDFNELLSYAQRVSKHTMSPINPNTWVIEPPIPQDSHMRMSLLFRQDQLLTEKTVQDDASNAGDHTMDLDLLSHDLPESSDHDAMHAETLLDLDFE
The following text describes a protein:
Function:
Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency. Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme. Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MWRSAVAALRGLSGFGRQPLRAVSSSPIDAQKGVTLSVTPPVGLADEPVHIQVQGLSPGEPVTVRALAVSYHGRLFQSSAHYEADGLGALDLTKDPSQGGDYTGVEPMGLMWSLSPAGMENPYIRMVQRSVLKKPLKLEVTVHQAHNQTGLLLGQVLASARVERWYATPEIRAIRVREGMVRGSFFMPPGDGPFPGVIDMFGDEGGLHEFRASLLACRGFATLALPYFAFEDLPPIMKDLNLDYFAQAAKFVQNHPKVKGPKIGVIGSGKGAELAFSMATFLPDVAAVAKATTIKEALARWEEKSGQKPSEAKEVKLYAQIPPVEKMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNYIEKLKGIHVMKRLKILYMSNNLVKDWAEFVKLAELLCLEELVFVGNPLEEKSSSEGNWIDEATKRVPKLKKLDGIPVIKQEEEEEG
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MLGRTLREVSAALKQGQITPTELCQKCLSLIKKTKFLNAYITVSEEVALKQAEESEKRYKNGQSLGDLDGIPIAVKDNFSTSGIETTCASNMLKGYIPPYNATVVQKLLDQGALLMGKTNLDEFAMGSGSTDGVFGPVKNPWSYSKQYREKRKQNPHSENEDSDWLITGGSSGGSAAAVSAFTCYAALGSDTGGSTRNPAAHCGLVGFKPSYGLVSRHGLIPLVNSMDVPGILTRCVDDAAIVLGALAGPDPRDSTTVHDPINKPFMLPSLADVSKLCIGIPKEYLVPELSSEVQSLWSKAADLFESEGAKVIEVSLPHTSYSIVCYHVLCTSEVASNMARFDGLQYGHRCDIDVSTEAMYAATRREGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIANDFINAFNSGVDVLLTPTTLSEAVPYLEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSIPVALSNQGLPIGLQFIGRAFCDQQLLTVAKWFEKQVQFPVIQLQELMDDCSAVLENEKLASVSLKQ
The following text describes a protein:
Function:
Required for cell specification of the PVN neuron.
Subcellular Localization:
Nucleus.
Sequence:
METDLLFQLLQPYFALLTSDVKPQRRTSHLIKDILDLPTVNGEIDEFGRCKSSLDQAKESPIEKCQKTKRKKARTTFSGKQVFELEKQFEAKKYLSSSDRSELAKRLDVTETQVKIWFQNRRTKWKKIESEKERSGEIPDDQIVKPQ
The following text describes a protein:
Function:
Catalyzes the first oxidative step of the phenylpropanoid pathway in higher plants by transforming trans-cinnamate into p-coumarate. The compounds formed by this pathway are essential components for lignification, pollination, and defense against ultraviolet light, predators and pathogens.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MASFVTKSMGFTLLAVASVSCIKFACPNLSTYFSPLPISVILPLLPLIVYLFSSVFTKSSTGDLPPGPVSYPMFGNWLQVGNDLNHRLLASMSQTYGPVFLLKLGSKNLAVVSDPELANQVLHTQGVEFGSRPRNVVFDIFTGNGQDMVFTIYGEHWRKMRRIMTLPFFTNKVVNQYSTSWEQEMDLVVDDLRANEKVRTEGIVIRKRLQLMLYNIMYRMMFDAKFQSQEDPLFVQATRFNSERSRLAQSFEYNYGDFIPWLRPFLRGYLNKCRDLQQRRLAFFNNYYIEKRRKIMAANGEKHKVSCAMDHIIQAQMKGEISEENVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQRKIRDEIRAVLKGSPVTESNLHELPYLQATIKETLRLHTPIPLLVPHMNLEEAKLGGFTIPKESKVVVNAWWLANNPEWWEKPSEFRPERFLEEERDTEAIVGGKVDFRFLPFGVGRRSCPGIILAMPILGLIVARLVSNFEMIAPPGMEKIDVSEKGGQFSLHIASHSTVVFKPIKA