lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSIQPGQVVTDPSDFAGTTIPELADLDSLLRCHICKDMLQTPVLTQCGHTFCSLCIREYLNKESRCPLCLAELRQNMLQKEFLVGELAACYMELRARLLETVRIPPKKVAEVVQNNSPIELDSDGEVEIIESCTGAVPGSKRGSPQVEEVEAAAKRQRTKQNGIQYMLQKKPKAVGEKVPCPICNRLYNKEFLERVHLDECLMMGTLRESGESDITVIEQQSYTAEPDSKNSHVAERRGESPVDEVVTHKESYLGSGLRVTKSRLPKLHFTSLSTSQLKQKLSELGLPTAGSRQQMINRYNHYELLWNSNFLDSIQPVGEGELRRSLLSWEATRNTDTPISSGVSSSITNMLKTNNSASTLLKSFKTDKFDKSAWSRLHGKEFRRLIRAAKKSMLEQDRGEAITAQNNELSTKASVDMESTSFRNDTNDTIDTVTDEVHEDLK
The following text describes a protein:
Function:
Iron-storage protein, whose ferroxidase center binds Fe(2+), oxidizes it using dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the BFR protein shell.
Miscellaneous:
MISCELLANEOUS: The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.
Sequence:
MAGNREDRKAKVIEVLNKARAMELHAIHQYMNQHYSLDDMDYGELAANMKLIAIDEMRHAENFAERIKELGGEPTTQKEGKVVTGQAVPVIYESDADQEDATIEAYSQFLKVCKEQGDIVTARLFERIIEEEQAHLTYYENIGSHIKNLGDTYLAKIAGTPSSTGTASKGFVTATPAAE
The following text describes a protein:
Function:
Functions as an inhibitor of the host RNA interference antiviral response. Inhibits the insect host cell apoptotic response initiated by the viral infection. Blocks as well the activity of members of the caspase family of proteases. Required for late and very late gene expression.
Sequence:
MCVIFPVEIDVSQTIIRDCQVDKQTRELVYINKIMNTQLTKPVLMMFNISGPIRSVTRKNNNLRDRIKSKVDEQFDQLERDYSDQMDGFHDSIKYFKDEHYSVSCQNGSVLKSKFAKILKSHDYTDKKSIEAYEKYCLPKLVDERNDYYVAVCVLKPGFENGSNQVLSFEYNPIGNKVIVPFAHEINDTGLYEYDVVAYVDSVQFDGEQFEEFVQSLILPSSFKNSEKVLYYNEASKNKSMIYKALEFTTESSWGKSEKYNWKIFCNGFIYDKKSKVLYVKLHNVTSALNKNVILNTIK
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLERDACLASNYALAKENLALRPRLEMGRTALAIKYQELREVAENCADKLQRLEKSMHRWSPQCALGWLQAELEEAEQEAEVQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQEVLRRRERSAQPAPTTAAAAAAAATAMDPPKPFPAAAVLPTGAARGPPPAVPRSLPPLDSRPVPPVKGSPGCPFGPAPLLSPRPSQPEPPHR
The following text describes a protein:
Function:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MANGLFTYVAISLFTIGPLLALFIPFVWRLVGSSLGWYLRRKTDGRRCHILEVVEADERKYRDSKSAKGRKAEKEDRDTFNNTEATGTSDGKVYDKDWDGIVGFFHPFCNAGGGGERVLWAAIRATQKRWPKAKCVVYTGDHDVSKEAILSRVEQRFNIHLHPPTVNFLYLSTRRWVLASTWPYFTLAGQSFGSLIMAWDAFSLLVPDIFVDTMGYAFALGFSRFLFRDVPTAAYVHYPTISTDMLESLDPASAVGSQGVNAGKGTGAKGRAKKIYWQLFARLYSLMGASVDVVMTNSTWTQAHIEKLWGPVRNLTGAVPGIKSKVNPIAVVYPPVAVEELEQEVEVSPESEKRRENVLLYIAQFRPEKNHQLIVQAFAEFLKSGSEAARDAKLVLVGSVRDDYDSKRVYKLRLLVNELHIKDRVEFHLDASWPDILEWLRRASVGVNGMWNEHFGIGVVEYQAAGLISVVHDSGGPKLDIVVEVDGEPTGFHATTSKEFAEGFEKALSLPNPYAVRLRARKSAKRFTEEEFARRWIEQLEKCVAIKAVEKPKSRQ
The following text describes a protein:
Function:
Catalyzes the deimination of arginine residues of proteins; Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development. Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins and proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, Cortical granule. Nucleus.
Sequence:
MSFQSIIHLSLDSPVRALCVLGMEICLDVNGCTPERCEAFTISSSPGVSVDLHGTLPGTGQEGTAVTRWPLSNPTDVLVKMTCPSSASDGDQVLVSYYLPDEDAPVATAVLRLTGIVVSLDVDIYRSGQVEIASDKQAKKNWVWGPSGWGAILLVNCSPADKGQIIDQKTTKVFFPEEIKSLSQMTLNVQGPGATLKKYRLVLHTSEEEARKARVYRPQRDSSSTFEVLLGPGQCTYTFAPLENNLKETFYVEAIEFPSADFSGLISYSVSLVEEPQDPSIPETLVYKDTVVFRVAPCVFIPSTQMPLEVYLCRELQVQGFVNTVMELSEKSNSQVASVYEDPNRLGRWLQDEMAFCYTQAPHKTLSLVLDTPRVLTLEDFPMKYSLSPGVGYVIQCTKDHRVASMDSIGNLMVSPPVKVEGKEYPLGRILIGSCFYPSKEGRDMSKALRDFLYAQRVQAPVELFSDWLMVGHMDEFMCFIPTQDKSEGEKGFRLLLASPSSCYRLFEEKQKEGYGDMALFEEVREDQLLSNGRQANTINQLLADKNMRKQNDYVEKCINLNRDILKKELGLVERDIIDIPQLFCLEQLTNVPSSEQTGKFFARPYFPDLLQMIVMGKNLGIPKPFGPQIKGTCCLEEKICQLLEPLGFKCTFIDDFDCYLTEIGDFCACANIRRVPFAFKWWRMVPEPQA
The following text describes a protein:
Function:
Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.
Subcellular Localization:
Nucleus.
Sequence:
MASFGLGKMSDFLLPTLSRKRDVDCIIRDTLDKVLVLRFGRAADPLCLHFDEILSKTSREVSKFATIALVDVDSEEIQVYVKYFDITLVPSTVFFFNAHHMKMDSGTADHTKWVGSFHSKQDLIDVVEAIFRGAMKGKLIVSCPLPPERIPRFQLLFKDV
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLVRFRVRNEYALGRPELHADADREDPKAVLDGVAVAGLVGILRQLGDLAEFAAEVFHGLQEQVAATASRSHKLTVRAQRIEAALPSLEKAILAQTSHIHFAYTAGSDWHARIRNRKHHFIDNDLPSFIMDSYEECRDTPRLHMLDKFDTGGPGSCLRRYSDPTFFRRVAASPDERNVGKVRGDKKAHKTKKRRSFPKNGELSRGVPMANHSGRMRIASPIANRKSSPTASIADSTFKSDFGDHRNSSDFRSGSGYVECIFHASDDMPPEEEESNRSSSSRAILHEETVDSVSPYEENQVINNYSPQKTSEESIASKSDYVRWDEKTEIMETREQKYEGMEDSATISMTSGVDAEEADKFRNVNTSDIDPCLIANTSKPKSRENEVDDMDSELDNYEDALNTIESESENDVDYQTKRELERRSPSVDIEEIKVTVDKLPSHASDDHPSHHELDTTSHLISNEEVCSELPKSDSSEICDNENMSQIPQKFVDSDCLPPLKVGQSSDLLDDTKVETLAGDAASVIFAPPRNEVTHNICEGQESPSEHTGVKFWTNGSLLGLEPAKPPDFAASNRESGVRNKGDQCDGKLDIFTENADSIERDASSKCSASCKINENSPSAGRTHILSSARDLDAKFGESDDLDRRCKSGHLNGDFSSPIRVVAPGTALPVAPMAKAAHSESIQENDDNLSGVFGLGHKLLMNSFRRKVSLVSDEKPKPYETVKDNVLEQSWRKSESSFHTTAGRNFIDQFQSVSPTYSLPPSPPLEHMKISFHPLHGFEASKLTLKFPHDKNRQESSNDVFPSFQLVPEPNVPIHDVCSDSDDGTFCRSSLYISDDCLSPHSESNSEQWESSDTAMSKEHDQFDAVCRLSSTESTSTSLEHGGTNNSKIHFNGECESLPTEDGLEPLPSFSSYVHGPSLDLPSFDSMASVPMQEKNVGRDPENYREKHYFHQSVPPAPPPPPVDWQLPKQYSDAAEVREEVSESLDHDPEGNNFDQSNFKQPKQGSALETVYIRAPELLSGKLQDQLKLNAHKEANQAKVKETDEREDFLLQIRNKSFNLRRTETVRPTAATARTTSENVTAILEKANAIRQAVASDDGDENDCWSDT
The following text describes a protein:
Function:
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).
Sequence:
MAGSTVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPTVRFVTKINMNGINNSNGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAESPFLASANTNTISQGSIWAVLVQPSFPDMVFEASALMTKGAPSQANPTTGTKSSHQPSEFALRMKEAAEAISGEHAGPTEKGDSEDADQMANDEAVENREHETEETKEAKRKIVEELWSKLQPSCFVRTDDRELEAATNLLLTLMLSFLSNHNKFPQFVSQLLEAIVTAEGKTTAYGRYTALFTLFNALPAPTAPTDNSVPLQLTILSRLADMAASHPEDLVILLPSLLRLPSYLTQWNLLGSPVGVATIEKVIRLCEQGGKLEDAFNLSILYLSSPALSNEKRCPDVDRVSAQAVKLSLTLPNCYDWDLLEDIVPISQYLNSNPEGETTYLKLISLLKSPSTKFDQIEQELTSNSNLKSALSEDTKSWVQRKARLLTLTDLCGNRVGGEVKYSEVKECLGLAVSIEEDDGMEVEEWVINAIKANLIAARLHQPSHVIYVTKASHRSFGTPQWANLETKLKGWGNSIEHLIRVVEQGLSSVESSSNLKGNQKMVSTAA
The following text describes a protein:
Function:
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Melanosome.
Sequence:
MDRARSAVTNFIGRYPLSYTRFSLTQQTDGDASQVEMKLADDEECGDQTMGEPVVKQRPENNCKRICMKILLGSFLILLGFLIGYLSHRGRDSSIQSKNPETVICSAVNDCNTIPPNDEDETNMETEMPSVLHWSDLAPILKSKIDNLFLKNSIDKISKISREAGTRNEESVALMVHEEFGQMSLDKVWNDEHYVTLQEPGSSPNKVTLLSDKEEILPPSAYVAYSPAATVTGKLVYCHYGRKEDFKAIQEKKIDLSENLILVRSGLISFAEKVKNAELHKAKGVLIYPEPSDLTFPLRQSGFVDSPFGHAHYGTGDPYTPGFPSFNHTQFPPSKSSGLPSIPVQTISSEDGKKLLEKLDGDNCPDTWQVACKLGPQIKDTQNIKLEVTNVPVEKKIYNVFGVIQGFEQSDHYVVVGAQRDSWGPGVSKAAVGTSLLLELARLLSDMVKTDGFRPRRSIVFASWGAGDFGSVGATEWLEGYLNNLHLKAFSYINLDSAIQGSGTFKVSASPLLNKVILQTLKEVADPVETDFTLYKQIGSQAWTKKIVPFSIEDSAYPFLAYSGIPSVSFSFQKDNKPYAYLGTKMDTLENFNQLVDLNRMCRTAAHFAAQIIIRLTHEQKLPLDYSSYNDVLLKVTFDLQQQFRAIKELNLTLKWVNSARGDFSRAAASLTKEFAHSDLENTLILRSLNDRIMKVEHGMLSPYVSPKDTPFRHIIYGSGNHTVAALMDHLNLLNTNKAAFDADLFKNQLAMLTWTLQGAANSLAGDIWDIDNNF
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MSDTTHYHRLKEEDDENLNKEIDTLSEQNEIHVISDEQQLSKNKVENKENKSDEEEVEMITFAEYSESVNAVITPVAITLLLTVIIVKLLERSNDLYSQATSYIFSEGIESSTTIPIWLIAIIVSVIFIIMIVIVTFVFVLLFYYRCMKLIVGWLLFSVILLLMLFGGSIMKSLLSVFNWPVDWISFAFLLFNFGVLGVISIFYISPMKLNQFYMIIISVFMASFFTNLPEWTTWTLLIGMACYDLVAVLCPKGPLRILVNLAQERKEPIPALVYSTAVWMGLASPDDSKNEILNVDSNPFTLSSTHGKGVKLGLGDFVFYSVLVGRCAMYDLTIVFSGSVAVLSGLFGTLILLVVFNKALPALPISIFFGTLIYCVSRWAIVPLVTTANLYGYVA
The following text describes a protein:
Function:
ADP-ribosylhydrolase that specifically reverses the SirTM-mediated mono-ADP-ribosylation at an asparatate residue of GcvH-L (SpyM50867), by releasing ADP-ribose from the target protein. May play a role in the regulation of the response to host-induced oxidative stress. It can also hydrolyze ADP-ribosyl-glutamate bonds and ADP-ribosyl-cysteine bonds. In vitro, it can remove the ADP-ribosyl modification from the human mono-ADP-ribosylated PARP1 E988Q mutant, which is primarily modified on glutamate site with only minor aspartate contribution. It can also hydrolyze the ADP-ribosyl-cysteinyl glycosidic bond of a Cys-ADP-ribosylated synthetic peptide.
Sequence:
MPSSFDLLGEMIDLLQTEQLTSYWACPLPNALTKRQDLWRALINQRPALPLSKDYLNLEDTYLDDWRASFVPVSVKDCQKTNYTSLFLYHGDIRYLAVDAIVNAANSELLGCFIPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQAKLTSAYHLPASYIIHTVGPRITKGRHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSISTGEFGFPKKEAAQIAIKTVLKWQAEHPESKTLTIIFNTFTSEDKALYDTYLQKENNCE
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MSTRRKGLSPEEKKEKIKEFFHMSPTIYSSKEIEAEASKYTGLTQVQCKETIQSLVEDGIVNSEKMGSSTYYWAFASFEFDQKKDKIVELTEELKNTKEKILNETKNIEKLKGERIDSEKRTKDIEKLQKLKDDNKEFKEELTNYADSELMEQLKKDVKTAIAAVNRYTDNISSLRQYCDKKFAIRGEDFDKNFGINPDMDYMEDYK
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MLGKVFLVFILQTLLFLTIVVSSTSSSEEDSSVEKESKEHHKGSHHWKYDDQELWPSTFEHCSGKSQSPINIETGKTIYDSSLPAIVLEGYDLSDKALLKLQNNGHTLQLNLPSTMHIVQGFDNMFIAAQLHFHWGTKEVPGSEHTIDNVHFPAEIHVVHYNSKYASLQEAATKPDGLAVLGGFIGIGLLENENYENILSSLTDVSLEETNTEIPGFNVRHLLPPNLERFYRYNGSLTTPPCFQTVNWTVFNDTISVSRKQLAALEDTLKAGQSLLSRNFRAAQLLHGREVYSSFKTLETTKVSESTVSLVVQNNVKSCATITSLTGYILAIAFGALFAITLLSFIIYAVQQRKKYSRFQKDSRQNVIYKPATKEEA
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).
Sequence:
MADRRNDVTWRSGYWLIRENDVTMARREYCLQLQGRCHGYYYPASTSHLQKRMRPIVRKNLQDQKVTLWSYLRSNFLNKQNLLFLGESNRVQFNTIYIKEAHAADEWALPVTNENLGVCFLQPKKLEARINIAKEFINRFQFQLPFFIDCIENETMKAYDAVPERLYVVDDGKIVYSGGPGPFAYSLDDMEQFLEKYVVEGQKSS
The following text describes a protein:
Function:
Plays a central role in chromosome cohesion during meiosis and mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting or Rad21 from cleavage by Sse/separase. Required during meiosis in both males and females.
Subcellular Localization:
Chromosome, centromere. Note=Localizes to the centromere of meiotic and mitotic chromosomes. During meiosis, it assembles onto centromeres during prometaphase I, remains attached until anaphase II, during which it is displaced from centromeres without being degraded. Localization onto centromeres is independent of kinetochore formation and cohesin complex.
Sequence:
MGSKVEQQYKLLNAELMDQVQKQRLEIGEYRKRVISLEREIMDIREEHVLQNHRQRMENISIVRSLMLSLNVDSDSLAVRQEPAPAAQINRPSGPRRSSREICKDMRRTCALARTTRPISPRRSSSVTSTVSSTSRRSSAEVQSEVVTTRIPEDRRANKPTPPPRRPAELVFDEDDSDDDFDEAVSPVEETQTEQNEENNRLFSIIEENGSEGESTDSSSSCEAIYCDTTFESSPPNAQVTVTPSGRALREVDTNIPVAVSLSRGKETGKGSWLAISVAVEDSPQEPSIQCPRLAVTRPSQSSGIFPDVNGLTPRRSLFNGIGKMAGSTSTPKSFLVEEMPSIRTRSRTAANKKSENTDMSSSFCNNSARPSRSCRPTSLVEPSLKNKLRNGSKGKAKAKK
The following text describes a protein:
Function:
Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.
Subcellular Localization:
Secreted.
Sequence:
MSICTASRTMTGWVQSFLLMAASVLSNAEDTCPDVKVIGVGASDKLTILQGCPGIAGVPGPQGPTGPAGAKGDAGAPGIHGKMGPAGLKGEQGNSGQRGQKGDKGDPGVPVPGTAQNCKEWLDQGGTISGWYTIYTPNGLPLSVLCDMETDGGGWIVFQRRADGSVDFYQDWNSYKRGFGRKESEFWLGNDNLHLLTATGNFQLRVDLTDFSDKRTYASYSNFRIPGESQNYTLSLGGFTGGDAGVSEKSRRVVDFFRDWNSYKRGFGHKDSEFWLGNDNLHLLTATGNFQLRIDLTDFSDKRTYATYSNFHIDGESQNYTLHLTGFTGGNAGNALSEHNGYSFSTKDRDNDIYEGNCAQQFKGAWWYTRCHLSNLNGLYLHGDHTSYADGVNWSMGKGLYYSYKVSEMKFRPQL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Sequence:
MTVVVKLGGSVITEKDQPETVADDRLAGLAGALADGDIDDLVVVHGAGSFGHPRAAAHDVSATDGVQDAAAIRDIAGTMEALNTAVVGALADAGVAAVPVHPASVAHRTADGALEFPTGAIETLLDDGFVPVLHGDIISHAGAGATILSGDEIVTHLARAVDADRVGLCSTVPGVLDDDGTVIPSITAFSDAAGALGGSDATDVTGGMAGKVRALLALGSPAYVFGPAGIEAFVAGDDVGTRING
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Sequence:
MKIFLKNDEENSLFNFDNSNQNNQLKILNGDNALQSSINSALSIFSILKTSLGPRSMSKLIIKDNGSYIISNDGATILSNIKVEHPAAVILVNIALSQDREIGDGTTSIVLLAGEILKSLTKLYFQAKFDGKLIHQTTITTILYQLLEIINNGILDSVSVEYDNSTTDTLFKLAGVALGTKHYSYWTKNLTTITINAIQNSINANQNSSIIIDIKNNIQICKLQGGNIDQSCFKNGLIISTKQIPSLININNNNSSIKLKTIIVGYDINKHIESTQSIHETIKSTQEMNKYYGISDNLILNFVDRLIRNKVTLVFFKHKITDFLSQLLYSNNISMVQDFNDTNSNFEADSIITKLSKLTNSIPIMKYDELDFHLLQQQQQQQQQQQQNEFEVYSCFGTISNFEIISKFEDDFYIYLNNNFKNNGLSCILLRGPTKDIVDDLEIGIIDSLYLIKSSLESTPMIVYGGGSCEMAISMKLLEYSNSININDNDNDNEINYNQNYWKKEISKTLSECFQIIPTILVMNAYNSCSNIKSPLETIAELSTIHSKKNQNQTEKQEEEEDNGGGSSTQCSLGIDGWTGEIKDMKQMNIIEPLILKKSIITASIQAVIALLRIDTIVSSSSFV
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQKPAGKREQGKKPPIIEIEGETGEDVAPPPPEELEPDPELSPEEAEQARKDYLLTRFWISARGFWGRNGDRLAWPFSIGLGMLIVLTVAFQYGINVWNRAIFDAIEKRDATSVFHLTAVFVPLAIGSIVLGVAQVFARMGIQRRWRAWLTASVLTRWLANGRYYQLNLVGGDHKNPEYRIAEDLRIATDSPVDFLAGVTSALLSAVTFIVVLWTIGGALTIALGGSTITIPGFLVIAAILYAAIASSSIVVIGRRFVQISEDKNQAEADFRYTLTRVRENGESIALLGGEEEERGGIDRNFTNVLRQWARLAGQHMRTTLVSQGSNLVAPVVPLLLCAPKFLDGSMTLGQVMQAASAFTIVQGAFGWLVDNYPRLADWNACARRIASLMMSLDGLERAEQGDGIGRIKRGETSNEAMLELNDLSVTLDDGTAVVGETEVVIEPGERLLVAGESGTGKSTLVRAIAGLWPWGGGSVNFHPDRRLFMLPQRPYVPSGSLRRAVAYPGAEDDWTVDEIGEALHKVGLDHLKEKIEEEGPWDQTLSGGEKQRLAFARLLLHNPDIVVLDEATSALDEKSQDKMMKMVTDALPKATIVSVAHRVELEAFHSRKIVLERRKGGAKLVSDIDLIPRKGRRRLLGRFLRPRRPAPTRAA
The following text describes a protein:
Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Sequence:
MQILQKIKSTKKKFGMRNLATVTYEALQYLEESPCKTQTRENIMNYVKDLSSYRLKSQEILQMINDPPTSALHTQLLIDDNKAPLTDEENEKIIQLSYKHFHGGETKGAAKETPAEKPAESTAKAGKQSGVKRNAQAKSNPAEQIAPADKTTPGDGVTPANVATPSSEATTTTPAEEASPVETSSSENNATPANEATTAPATDAPTSMETKSNPTPDGENLG
The following text describes a protein:
Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Sequence:
MPRRDLVRIVLVGDDGVGKSSIITSLIKEAFVTNVPHVVPEVTIPPEITPENFTTSIVDTSSNPRSRPHLLSSISRAHVICLVYSIADPSSFDRVAEYWLPLFRREGINVPVILVGNKIDLRGGRVTNQGLEDESAPIMREFKEVETVVECSALLPLNVSEVFYFAQKAVLHPTAPLYDSREHTLKPKCLEALKRIFTISDVDKDGLLNAHELNQFQQKCFSTPLQSQELDGILEIVRSYDPYAVQPLPSSSPNTPLSRDSSYGQLHYFNNNVVPPSPPQEGITELGFLYLHTMFIQQGRMETTWTVLRKFGYGESLDLREDFLAPKFDVPSDCSVELSPLGNQFLTDIFEAYDKDQDGALSQNELDDLFSTSPGNPWLSQGFPDTTITDDMGRVTLQGWLAQWSMTTLLNHRTTLNYLAYLGYSSSPATDLPTPTALHVTRPRKQDRRQRKVTRNVFLCYVLGATGSGKTSLLRSFVNRPFKGGEDGLGGYEPTTKVLSVVNSVEMEGVEKYLVLQEFGSKYESEILRNSKRLDMADIIIYVHDSSDTNSFSYISNLRQQYSLDHIPSIFVATKSDLDLAQQRHEVQPDVYCRRLGLQAPMAVSSRLGPLHNLWVAITRVALDPTSSLPRGPRSQMSPAQRIRVVARWGLAATTISAIVAVWMKWQGYSFKGIWGWMAKFAGLRT
The following text describes a protein:
Function:
APS kinase catalyzes the synthesis of activated sulfate; Catalyzes the synthesis of activated sulfate; Proposed to provide activated sulfate for transfer to Nod factor. ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity.
Sequence:
MNMIVTPASPATPNGTTRPQVRIVIVGHVDHGKSTLVGRLLHETGSLPDGKLEMLKAVSARRGMPFEWSFLLDALQTERDQGITIDTTQIRFRTNSRDIVLIDAPGHAEFLRNMITGASQADGAVLIIDALEGVRDQTRRHGYLLHLLGVKQVAIVVNKMDRVDFSADRFQAISDEISAHLNGLGVTPTAVIPISARDGDGVATRTDRIGWYKGPTVVEALDQLEPARPLEALALRLPVQAIYKFDDRRIVAGRIESGSLVAGDEIVIMPAGKIAKIKTVESWPATPIAGRQGAGRSVGITLDRELFIERGDIVAHAGSAPRETRRLRARIFWLHDKPLAKGDQLLVRCGPKESRATVVAIEKAVDPGELSSVENKAIGRNHVGEIDISLSNPIATDPYTENPRTGRLVIEVSGRIAGGGLVLSVDAGQRAVPVDIVPVESALRPDERSARYQHNGAVVWLTGLPASGKSTLAKALERRLFTNGGSPILLDGDTLRAGLNNDLGFSASDRSENIRRLAEVATHLARNGHIAIVAAVSPAREDRATARRIADTAFREIHVATPAGVCEERDPKGHYKKARAGALASFTGIGNDYETPQAAELVIDTSTRTVTEAADEIEQMLKTTGVLFDEVVDLAANI
The following text describes a protein:
Function:
Transcription factor-like protein that binds to specific DNA motifs called ub-HS-motif associated with several locations where proteins other than histone H2B are ubiquitinated (ub-hotspots). Ubiquitination at these sites depends on the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 and protein turnover on the CDC48 segregase. UBC9, SIZ1, or SIZ2 sumoylate DNA-bound EUC1 to stabilize its DNA-binding. Sumoylated EUC1 acts a cofactor required for the recruitment of the SLX5/SLX8 STUbL complex via specific contacts between EUC1 and SLX5, as well as an additional SUMO-mediated interaction. SLX5/SLX8 then ubiquitinates EUC1 and presumably other targets at ub-hotspots, and the CDC48/UFD1/NPL4 complex, together with UBX4 and UBX5, removes Lys-48-linked ubiquitinated proteins from chromatin. Ubiquitinated proteins could be either degraded by the proteasome or recycled by deubiquitination. EUC1 itself does not seem to underlie extensive turnover, as it is a very stable protein. EUC1 is able to act as a transcription factor, but its function at ub-hotspots does not seem to depend on this ability. EUC1-mediated ub-hotspots are crucial during stress responses when gene expression control is impaired.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Chromosome. Note=Localizes to few distinct genomic hotspots where proteins other than histone H2B are ubiquitinated (ub-hotspots).
Domain:
The coiled-coil motif is required for homodimerization.
Sequence:
MPAREYNYVEGFGGYGSLDDDDSDRDSERRNHDLGQRTITTSPTGVSRHAALNRYMIPGRINPLFRPTDAAQPPIVSTSTSASATEPTNRIGPGRIKETPETNFNAFLIAQLTRMEEQNANLKEEISLMKKEQELFFLENQKKLEKGFKDINKYVEDVSAMKEVFKEVVGIMTGERIRFIDHTGENVTPQEAARVGNPSTSTQAHQSQSRSTNWQEYSMHASILAGDPRIKPEPGLSDFENGEYDGNESDENATTRNLPLNNPDSVSNADDSNNQLDGTGNENDIRNRRGCVGTSYKLNRAIQNVTDAAREYFEGLPGQPSVLSLERRYGSTWRRSAKERTLFTKRMTIIKRIIDIKDDPSKYGLSLPENKISRNQAIKVVENIRLGNNTFKGHHCRLSMSQLYEYFSKKMDKLEDYSLTLKRRGKPRRIFLLEEREARLSLQQPHSIPNSSTGTPEHDQDT
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRKVGALEKIEADHAALRYKLKRDPQSYRDDFNNQYQQYETLRDLFLQNPSATDSGLVALKDLIEFISHVADRYPDLTSKFPGELAQILLQHHEVLEYDLRDKIVGSIVLLRNKDVIDSTVLLNTLFPILVSTPSKSLRQLLFTKILSDLRSSNVKATNHKLNRTIQTVLYNLLESDKQSPKGIWAVKIAREMWKRQIWTDARAVEVMRLAALSDNEKVITGGVRFFLGGDKEREEAAEDSDDDEDVDIARLRHQVGINKKSKKNQRDLRKASIAVKKKQHKKNAPHPLNFSALHLLHDPQGFAEQLFSKHVQNSKSKLQLESKLLVLQLVSRLVGLHKLTVLSLYSFFLKHLTPRQASVTSYLACLAQATHNYVPPDVLEPLVQKIANEFVSEASASEVAAAGLNAIREICVRQPLAMTDTLLQDLVQYRKSKDKGTMMAAKGLLSLYREVGADLLHKRDRGKDAAMGIRAGTIKERRYGEEAVGEVEGIELLEKWKEEERRKKREAAGLDPDADDGEEPDETEDWKAWDVESDEESDDSGGWINVESDGEDIQISDSEDEKDKSKAKAKQPPAKKRKLSNATTDAADDKKSEEPEIKSISKLLTTTILTPADLKQLRALQEASAISSSLPSHKRAQLLAARHADEAITAETIEAAASLGKKNTKEEKIAMAKGDRETNHQSTTAKRKEKKIAEGKSTTNKEKARKKNFLMTLSKAKSKNKRTSDGC