lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential for Spemann-Mangold organizer formation and subsequent anterior head development in the embryo. Inhibits canonical Wnt signaling pathway by antagonizing nuclear import of beta-catenin (ctnnb1) during embryogenesis.
Miscellaneous:
MISCELLANEOUS: Named Custos for the Latin term for 'guard' or 'keeper'.
Subcellular Localization:
Nucleus envelope.
Sequence:
MSESSSEDENTARLKEAVWSFKPEDVKINGKENNGRQSHRADVSKHEHDGNELGTTPEFRSHVAKKLGTYLDGCISEVCSDTVEPAQSENREDEEGFRLFSSSTPGKWMEQSPPPPPKRRPVPSSSDSDSEMEMRFREAAVSLSDILGPVAQNLSEKTEEKSTKEETEDTVTKMKKKKKRKTSSEESQDKVNHQTEKQSNVEGNQEQTTAGERLKKKKKKKKKKRKKLEKDIKKDE
The following text describes a protein:
Function:
Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
SDRLVGSTLLIIALLVFSYYTIWVFLLPFVRPDHVLHAYFLAPEWAIRIPVGLLVVGFSGIFGFISLVLLQNGKKK
The following text describes a protein:
Function:
In higher plants aldehyde oxidases (AO) appear to be homo- and heterodimeric assemblies of AO subunits with probably different physiological functions. Involved in the biosynthesis of auxin.
Subcellular Localization:
Cytoplasm.
Sequence:
MEMGKAAAVVLAVNGKRYEAAGVDPSTTLLEFLRTHTPVRGPKLGCGEGGCGACVVLVSKYDPATDEVTEFSASSCLTLLHSVDRCSVTTSEGIGNTKDGYHPVQQRLSGFHASQCGFCTPGMCMSIFSALVKADKAANRPAPPAGFSKLTSSEAEKAVSGNLCRCTGYRPIVDACKSFAADVDLEDLGLNCFWKKGDEPADVSKLPGYNSGDVCTFPDFLKSEMKSSIQQANSAPVPVSDDGWYRPRSIDELHRLFQSSSFDENSVKIVASNTGSGVYKDQDLYDKYIDIKGIPELSVINRNDKGIELGSVVSISKAIEVLSDGNLVFRKIAGHLNKVASPFVRNTATIGGNIVMAQRLPFASDIATILLAAGSTVTIQVASKRLCFTLEEFLQQPPCDSRTLLLSIFIPEWGSNDVTFETFRAAPRPLGNAVSYVNSAFLARTSLDAASKDHLIEDICLAFGAYGADHAIRARKVEDYLKGKTVSSSVILEAVRLLKGSIKPSEGSTHPEYRISLAVSFLFTFLSSLANSLNESAKVSGTNEHSPEKQLKLDINDLPIRSRQEIFFTDAYKPVGKAIKKAGVEIQASGEAVYVDDIPAPKDCLYGAFIYSTHPHAHVKSINFKPSLASQKIITVITAKDIPSGGQNVGYSFPMIGEEALFADPVAEFAGQNIGVVIAQTQKYAYMAAKQAIIEYSTENLQPPILTIEDAIERSSFFQTLPFVAPKPVGDYDKGMSEADHKILSAEVKIESQYFFYMEPQVALAIPDEDNCITIYFSTQLPESTQNVVAKCVGIPFHNVRVITRRVGGGFGGKALKSMHVACACAVAALKLQRPVRMYLDRKTDMIMAGGRHPMKVKYSVGFKSNGKITALHLDLGINGGISPDMSPMIAAPVIGSLKKYNWGNLAFDTKVCKTNVSSKSSMRAPGDAQGSFIAEAIIEHVASALSADTNTIRRKNLHDFESLAVFFGDSAGEASTYSLVTMFDKLASSPEYQHRAEMVEQFNRSNKWKKRGISCVPVTYEVQLRPTPGKVSIMNDGSIAVEVGGVELGQGLWTKVKQMTAFGLGQLCPGGGESLLDKVRVIQADTLSMIQGGVTGGSTTSETSCEAVRKSCVALVESLKPIKENLEAKTGTVEWSALIAQASMASVNLSAHAYWTPDPTFTSYLNYGAGTSEVEIDVLTGATTILRSDLVYDCGQSLNPAVDLGQVEGAFVQGVGFFTNEEYATNSDGLVIHDGTWTYKIPTVDTIPKQFNVELINSARDQKRVLSSKASGEPPLLLASSVHCAMREAIRAARKEFSVCTGPANSAITFQMDVPATMPVVKELCGLDVVERYLESVSAASPTNTAKA
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MAHGVPFDHNYYIVECKEETNAEAQAGAMAATSTEEAPGAVEVAQAAVASSHDSGGAIGCATVKESESDSESESDSESESDSSDSSDESDDDSSTSDEDTSDPEEAAAPSVAAVAAAAAPPTVPAAAAIQIPGPYRYRPPRRHVRRRRRGPPFHFAQWQVEEMESLFEETQYPDLLTRGELARTLNVPEVKVKVWFTNRRAKQRKIERREMLRNIPPGAEDFIFITDFEEPS
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MANLEFFGAQQPPATAGNGATDGAEEDPAAAFLAQQENEIAGIENDEGYGILESGDVPEALQAADGFDSGAVDGVMNGVVYQESNGPTDCYAAISQVDRLQSEPESIRKWREEQKERLEQLDANSRKQEAEWKEKAIKELEEWYARQDEKLQKTKASNRVADEAFYKQPFADVIGYVTNINHPCYSLEQAAEEAFVSDAEDVFPGTEWERVAQLCDFNPKSSKQAKDVSRMRSVLISLKQAPLVR
The following text describes a protein:
Function:
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
Sequence:
MAAVAAEGRRVLVYGGRGALGTQCVHYFKAKNWWVASIDVVENEEAHASVIVKMTDSFTEQAAQVTVDVDKLLGERKVDAILCVAGGWAGGSAKAKSLFKNCDLMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGNNSGLPPGSAAIAVLPVTLDTPMNRKSMPDADFSSWTPLEFLVETFYDWIVGKNRPSSGSLIQVVTTGGKTELIPAYF
The following text describes a protein:
Function:
Initiates the restart of stalled replication forks, which reloads the replicative helicase on sites other than the origin of replication. Recognizes and binds to abandoned replication forks and remodels them to uncover a helicase loading site. Promotes assembly of the primosome at these replication forks.
Sequence:
MKFASVIVDVPARQTDRPFDYIIPKKWEDIVQTGMRVVVPFGPRKLQGFIIGIKDSVDVESKKLKTIHEILDVTPVLNDELLKLGYWLTSETLCYMISAFQVMLPTAIKATYKKRLQLCKQEEIAPEILYLFQDKEAIDFEVIEQQPHLYRTIQQEIKNGTVEVVYQVKDKVQKKKQRVVQPELPEDKLELAAFELKSKKQQDVLYYFVENYKSTPLKVITEELQITDAPIKALVKKGFISEKYVEVYRNPYDDDDFEQTKPFPLTEEQKQVITPILSSITNETYNPFLLYGVTGSGKTEVYLQSIAAVLKKGKEAIVLVPEIALTPQMVDRFKGRFGSQVAVLHSALSVGEKYDEWRKILRKEVKVVVGARSAVFAPFENLGIIIIDEEHESSYKQEDNPRYHARDVAVWRGQYHKCPIVLGSATPTLESFARAKKGVYELLTMEKRMNEQALPTVEIVDMREELRDGNRSMFSKALHEKIADRLEKKEQMVLFLNRRGHSTFVMCRDCGYVVQCPHCDISLTYHKMNHRLKCHYCSYEENMPTECPACQSTYIRFFGHGTQKVEEEITKLFPEARVIRMDVDTTSRKGMHEKLLKAFGEEKADILLGTQMIAKGLDFPKVTLVGVLTADTMLHLPDFRASEKTYQLLTQVSGRAGRHELPGEVVIQTYTPEHYSIELAKNQQYDVFFDQEMQMRRTRQYPPYYYVVLVTVSHPELLKAVQVTEKIASYLRTHCSQQTMVLGPVASAIPRIKDRYRYQCMIKYKREPNLKNVLKMVNEHYQAEMQKELQISIDFNPTMLM
The following text describes a protein:
Function:
Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2); Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Secreted, extracellular exosome.
Sequence:
MQVTVKTLDSETRTFTVSEELTVEEFKKEIADTVGIPAERQRLIFKGKVLQDEKKLKEFEVDGCVVHLVERKPPRTQPDGASNSPDGPSVHPGSQAASSAANIVMGAFNMPVDVMGISQNIVQGLVSHLGVDASHANVSSSHSSDGSTLNVHINLLSAPPEGNDAARRLSRARHFVRAARESFNRTEGEAPSSMDANVPTDDRPAPNQGPQGNTEQPRPSDLADVLGELQEFSSQLQPSLNRYTSLLNSPATENLLPSDDSLPDRIAETLHNLSHAYHALSDLSINIRAPEPRRLSVLTPLSPHVGAPNLLSSIFGGRPPPGPTTSRQNVSGQAGPTNMTQSSTSHSSTPRHHGEPQTTISITSIISSAIPRGHMPTTPSTTPQATPPSTTSQTTAPTASQAPSAGETPQPSTATTGEEARVMMDDFVNLISNLGQMTHGHPAASASQGAGQTGLHVHIGPRPPMGPPPPPGFNLHTGPRLHMGPPPSGFHAQRGPQPEMGPTPQPHPYVPPMGPIRVNPTQAHRQGMAHPDPSLPCESFHFGLRAHRAQPSQQPGEAQGTQQPGSAPTQGTQQSESAPTQGTQQSGSSSVEGPGRVFEQLVASVVQNAVSGGAALAQQAQTPDSLKPQTVSSPRQSQTPDSLKPQTVSNPRQSQTPDSLKPQTVSNPRQSQTPDSLKPQTVSSPRQSQAPDSLKPQTVSSPRQSQAPDSLKPLTVSSPRQSQAPDSLKPQTVSSPRQSQAPDSLKPQTVSSPRHLYVSIAYQTLNDVILELQNRGLDTSSEPISIQGALLSQDYQDWNIFIHAGYAGHHAGLRVVLRSYLFTDLLLGEEATESRLQELSVQFVSQVLDEIAPILTSESTCDGIDVVATVRKFLEYFAKRAFTLIRDADEQTFCNAFPFMVRGMSSDFVQLLALCYQNGLRDVENIITNRLPGTIVARDMGPVMLRTFRETLLRYVRDASQVPTQTNLQDYIIKASQEQKGSSQSVKPMPSDTVPVCQPDTAEDMSQNSDDSFHTPPGSVVTGGPEASQLAIDQGEVHMAVDDLEDDWKAVVPEEWVPILAQDVMRQRRIPPQQPFSDAYLSGLPPKRRKAMLATGAPRNSIDAVTESARTNSKLHQAYREEVKETVKKRTDTDTDFSSERFPVTSQYTCK
The following text describes a protein:
Function:
Involved in the vesicle trafficking. Binds syntaxins (By similarity).
Sequence:
MSMDSVISSRSGADYRSFRQITRDRLLFEMLRSTKKSSKSAWKVLIMDKLTVKIMSFSCKMADVMEEGVSLVEDLYMRRQPLPLMDAIYFIQPTKENIRIFMSDMSGKIPLYKKAYVFFSSPVQRELVAQIKKDSNVRARIGALSEMNLEYFAIDSQGFTTDHDKALEELFSENAEGSLKYNSCLNMMATRIATVFASMREFPRVHYRVARTIDASTLTTLRDLAPTKLAAGVWNCLARFKAMIPEFPQTETCELLIVDRSIDQIAPIIHEWTYDAMCHDLLCMDGNKYVQQVPSKSGSGTENKEVLLEDHDPIWLELRHVHIANASERLHEKMTNFVSKNKAAQLHQARNGGDLSTKELQKMVQALPQYSDQIDKLALHVEIAGKLNSTIKEQQLKDVGQLEQDLVFGDAGTKELINFFRTHLDISRENKLRLLMVYAAINPDKTRSDKGAKLMQLAGLSADDMIAVSNMRCLCGHDSKKSSAGGFTLKFDLRKKRHGIRKERIGEESKWMLSRFYPILEELIEKLSKGELPKDEYHYLNDPSPSFRGIPSASTQTSPAHQPAQSMRSRRTGGTWARPRDSDDGYSSDSVLKHTSSNSRKLGQRLFVFVIGGATRSELCAAHKLSSKLKREIILGSSSLDDPPQFITKLKMLSTDDLTLDDLQI
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MSPISLSANGTHISMKRESLAEDYADKKKKPPHKFMLKIKSSPLVFPAISLSAYGKKIPVNRHSLAEDNEKKKPMKATTNRQHQPLSAKGSQNTVKRNSLSQDLDDEYEENKKATTGNNKQVQIKPERNRNKIKIIFLLKRKTKTVIEQGQSSKIFCGICFDSVTDSNMFSTGCNHPFCTKCICKYVKNQITEKVVKLNCPDPECSDKIYCPYNNCSLLMVNDAACAVTSCECSSCHRLFCVQCKVPWHTDMNCRQFQKSMSENQLDKNFLKLAKREKWQRCPKCSMHVQKTGGCVVFTSATCVVGIGNRGILANIHELGILSKCAYYWVSYVIVS
The following text describes a protein:
Function:
Positive regulator of amino acid starvation-induced autophagy.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm, cytosol.
Sequence:
MSKMDGLSTGEEEDSTFTSISLEDDTDHSLKSWRSRAESLLPKMMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAVKEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Sequence:
MEHHTRIKLYMWDFCQCDPKRCSGRKLVRQKLVKTLPINASFHGICLTPDSSASLLTPADAEIIARNGVAVIDCSWNEYSAGRGVNEVKRLKYRNGRFLPFLMAGNPVNFGRPFKLNCAEALAGALAICGFMKDAQSIMEVFGWGETFLDINKKVIKEYTQCKTLEDVLNVQKAYTETDENIKEKREQERAKMFDIPDSDEEGEEEYFNPNRMPIEEEESSEEEEESSEEEEED
The following text describes a protein:
Function:
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
Miscellaneous:
MISCELLANEOUS: There are only 150-300 molecules of photolyase per yeast cell; MISCELLANEOUS: Present with 688 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MKRTVISSSNAYASKRSRLDIEHDFEQYHSLNKKYYPRPITRTGANQFNNKSRAKPMEIVEKLQKKQKTSFENVSTVMHWFRNDLRLYDNVGLYKSVALFQQLRQKNAKAKLYAVYVINEDDWRAHMDSGWKLMFIMGALKNLQQSLAELHIPLLLWEFHTPKSTLSNSKEFVEFFKEKCMNVSSGTGTIITANIEYQTDELYRDIRLLENEDHRLQLKYYHDSCIVAPGLITTDRGTNYSVFTPWYKKWVLYVNNYKKSTSEICHLHIIEPLKYNETFELKPFQYSLPDEFLQYIPKSKWCLPDVSEEAALSRLKDFLGTKSSKYNNEKDMLYLGGTSGLSVYITTGRISTRLIVNQAFQSCNGQIMSKALKDNSSTQNFIKEVAWRDFYRHCMCNWPYTSMGMPYRLDTLDIKWENNPVAFEKWCTGNTGIPIVDAIMRKLLYTGYINNRSRMITASFLSKNLLIDWRWGERWFMKHLIDGDSSSNVGGWGFCSSTGIDAQPYFRVFNMDIQAKKYDPQMIFVKQWVPELISSENKRPENYPKPLVDLKHSRERALKVYKDAM
The following text describes a protein:
Function:
Factor for control of RNA levels of a group of leucine-specific genes.
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MEGRSDFVATSQSGSEMSHSETRNRTGMNARKRKFACVECRQQKSKCDAHERAPEPCTKCAKKNVPCILKRDFRRTYKRARNEAIEKRFKELTRTLTNLTSDEILKKIEEEQEIVLDNSNFTKEKVKQLRKSAFETTEIEPRSYKTLRGEPISYSTNRRHTDSSPLTLLSSSTNFDPVHSTNVMTDDQLKCLPKSLGDVYLSSSDIAELFQEFATKYHQFLPVVDLSKGAERIYHLSPCLFWVILLIGLRRKFGATDLMTRLSVLVKSVLSEITISPIIRYTPSDKDEPVLNVASVYSVQAFLLYTFWPPLTSSLSADTSWNTIGTAMFQALRVGLNCAGFSKEYASANSELVNEQIRTWICCNVVSQTVASSFGFPAYVSFDYLVISSIRVPNSKSQVDIPNELRQMAQIARFENQIVNTMNSTPASVTGMVSQEEKQPLLHVLNQQLSQLEISLEENNLDDIRKFLLLVAKVHLLTYYFTDVTSQSAGKSNGNIYEGSYSIMELDTSFETKRGLVKVYNAAVNFLIHANSMWEHDPTIIKYFPGLFVLNIWQSACIISKLIHSSLHSMLDVNSGKKAYNNAISLTFNASVLKYDMAYRSSGIMRSIWSLFANMYDAWKNDQKEGGGRLNNDFNLGITIKSRMSVNVFFDCLYILKEKCGMAKLERETKVSTAYNVDEEEEEDEDEEGEEEEEEEELSSKVPENMDSQQLRTRKFTNVRHPEKKARKIIETIPLDPNPINAGSTSSGSSLTTPNSQVANTISYRGILNKMSPREQLNHANLDSSVSTDIKDTEAVNEPLPIGRNAEHPANQPPLSITQMQENTLPATQANSSLLETYPIVQSNPVTTTIKESPNSIMAGWDNWESDMVWRDVDILMNEFAFNPKV
The following text describes a protein:
Function:
Together with methyltransferase TRM7, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 7110 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTDVQFSSQEIELFRVKEFLIANNPAKINNENKDAVLTQIEHDFRYLIQYIKDGLPNLNESTRLIFPDTFSICLLRSHQIIASKKIDSQEFLSAVKEQLLTEANANIIFEYVLDFWADGGAPLMNALRDLFSKLLNLLKITYPMSTLKDVLFNWMNEILEVPSTLRVQYYLIDALSSDFDLYYIIEKKPHFIDNSFSLMNSDLLANSVGKCIVSLLLNIYEKHFKKNESFVQEWIQLWKSCALKYIHDKQYTKSINLYIMIPLFKNMPNSAFTLFLECMSNKDPSLLLSLLKIGQELGIEEEPFCDNKYTTVDSVNKLIEQDEYKLQVFEILTFSTKKSKPIRPFVFKTIKQYLYVFFVDTELERRNYFCSSMKHFIFRTRDCAYSLARDARKLKKAEKFPDEQREKLAQVEEARAFLVWLCNFIKYNLAPGTLYQANVTSLKLMHILIKSGVDKSTPQKFLDNQNKREYPFSIPILQDVTFLRLLIDLLVSNYADVRELSKEMLFIMISADESRGLFLDTLDANALKWTATSLLSDYEKGDAGATVYEFIFTVMGSQRSFIDQTIDILAQMVQNLQNDSIGCAENSIGPHFAALSLILNKFNSEENHQDTSKIISKLINLVLKSWEATRNVVCHDSAHGILPEKYANCGVPDQVIISHAFRAIKEASYLLETILKKYPLTRDQLDSIGDLFIVQLSTIRHSGAFQAVLPGLKAFCIRCQLEFPAILEELLSKSVKSLKSKTQHITRRSGGLPFLVTTVLSAEVTKGRPLLQKTFENLLLVARLPIPPHQDEFDLPQVNAINCINAIFVEPKLSVHCTSFVSEALELALLNFDCDIWALRNCSIMLFTSLQNRIFGKVGRSVSAKLFFTKYSGLRQLLLNILNSSIAQYSGSERKSYQIESIFLVLNVLLRLRPTAGYTGLKEFNVSVYECLSNENWKIRDMASRVLHMLSENFEEEIRKLLDLASIAKQNQLHGHLLALQQLVPQYLSGTRDMELIQRILEKKRMLLLENKCFITKKAYLKLTCCILETCDIPDSILKDYISTLRNTFIAENNEYVVDGSKQLYLAQILDMLLKYEDSIYLDDICLLGLYSPFYEAQLSTLQYMNTNFHWETTRNSEFLEQLQLLLRVPDLLPMAKALVVKILSRKKNTLSLTTCTDLLKTNNSEDTKLAAVSSLSAKLSSQTFHQVWNLLQGFFADSCSKDFRLASLECLTAYPESCKNSRILLQLYNFLWDDDSEIREKASFYLNKNFIQTADWEYNRNTSVTALIFTKKFVDVFTSSEVVEELCLQLFQYLNEYDMFAAEESAKNCLFTIEKDNQFINELQKAMHILNMIKLTGRDISKCYKDQIHHLKSALLEHFNTEDFKDSPLGWCSNAEIFSRITLLKELIQHYSPSDYENFINVLTKHSVHPLIISYSQL
The following text describes a protein:
Function:
Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons. Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr-12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation.
Subcellular Localization:
Membrane. Secreted, extracellular space. Cell projection, dendrite. Cell projection, axon. Note=The non-secreted form shows punctate expression in dendrites and is also involved in synapse formation/remodeling. May also be secreted by coelomocytes.
Sequence:
MFSELRILRDILLLCFLSVGINAKSSHIEDLDFTDHTNGSPKISRSSYFKQDFRLGYKLKLFCESSGNPRPQIVWYHRGVEVNPDHNRTIRFSIHGDTVSSHLEVDPTSIGDKGEYECVATNLKGSRVKKFLTDYQY
The following text describes a protein:
Function:
Glutamic endopeptidase that preferentially cleaves peptide bonds on the C-terminal side of proline residues. Also cleaves peptide bonds on the C-terminal side of alanine residues but with less efficiency. In contrast to most proline-cleaving enzymes, effectively degrades proteins of any size. Found in the viscoelastic fluid of the pitcher, and so likely functions in the digestion of their prey.
Subcellular Localization:
Secreted. Note=Secreted into the viscoelastic fluid of the pitcher.
Sequence:
MQAKFFTFVILSSVFYFNYPLAEARSIQARLANKPKGTIKTIKGDDGEVVDCVDIYKQPAFDHPLLKNHTLQMQPSSYASKVGEYNKLEQPWHKNGECPKGSIPIRRQVITGLPVVKKQFPNLKFAPPSANTNHQYAVIAYFYGNASLQGANATINIWEPNLKNPNGDFSLTQIWISAGSGSSLNTIEAGWQVYPGRTGDSQPRFFIYWTADGYTSTGCYDLTCPGFVQTNNYYAIGMALQPSVYGGQQYELNESIQRDPATGNWWLYLWGTVVGYWPASIYNSITNGADTVEWGGEIYDSSGTGGFHTTTQMGSGHFPTEGYGKASYVRDLQCVDTYGNVISPTANSFQGIAPAPNCYNYQFQQGSSELYLFYGGPGCQ
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDHLNQPHSMGTTIIGVTYNGGVVLGADSRTSTGVYVANRASDKITQLTDNVYLCRSGSAADSQILSDYVRYYLHQHTIQLGQPATVKVAANLVRLISYNNKNMLQTGLIVGGWDKHEGGKIYGVPLGGTILEQPFAIGGSGSSYLYGFFDQEWKEGMTKDEAEKLVVKAVSLAIARDGASGGVVRTVTINSEGVTKNFYPGDTLPLWHEELEPQNSLLDILSSSSPEPMVS
The following text describes a protein:
Function:
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation.
Subcellular Localization:
Nucleus. Cytoplasm. Endosome. Golgi apparatus.
Domain:
The two SH3 domains and the SH2 domain are necessary for the reinitiation of oocyte meiosis.
Sequence:
MEAVAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLGKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQVHGGDRATNLLQQPTYVQALFDFDPQEDGELGFRRGDFIQVVDNSDPNWWKGTCLGQTGMFPRNYVTPVNRNM
The following text describes a protein:
Function:
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Sequence:
MATPQPVDARTQPWRETPGGDLVALGRPVRQALHLVRHNPAQGRVLSRRETILLVLFALTLHGAVIHWLSQQRTPALPEVPPQVPPMTIEFTAPAPPVVEPPPPEPLPPVVEEPPPPVVDENAVKPPPPKPVPKPKPKPKPQPRPKPAPKAVEPAPPAPPQPAAPPAPPAPAAAPAPLTPPSANAGYLHNPAPEYPALAMRRGWEGTVLLRVHVLASGSPSEIQVQKSSGREALDQAAVKAVKRWSFVPAKRGDKAEDGWVSVPIDFKLN
The following text describes a protein:
Function:
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MVLCVLFITRLNFHARGMSQQMPGWFVTPGALTLRWYHGNLTRHAAEALLLSNGCDGSYLLRDSNERTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLIVLKHPYPRKVEEPSIYESVRVHTAMQTGRTENDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLDQGEGTIRSRSFIFK
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTYGSKQVRKTSGSNRRPPPPRRSGGVSRPNPWTALLLLLTLLGSLLYIWRPWEHKNDPWSLWNDQYQFMTLGLDLKGGLRIELAPESGTATRDELDRVKTVIENRINALGVAEPTVTVSGGKRVVVEIPGATPAVQDRARSIIQQTARLEFRIVNSDAKPDPAVREKNPRSSGYTLAQLGPVVATGETIADATSGTDQRSGQWVVNFKTTDAGAKTFGDFTGKNVNRLMAVVLDDQIQSVATINQRLFRDIQISGNFTPEEASQLALVLKSGALPIKIVTAAERSIGPSLGADAIRSGAIAALVGIGLVFVMLFAYYGLWFGLVGALGLLFSSIIILGILGGFGATLTLPGIAGLVLTIGAAVDGNVISFERIKEELARGKGIKNAIGAGYEHSTAAILDVNASHLLSALALYNYSTGAVKGFAVTLIIGVIASTFSNLVFAKWFMQWLAQRRPNMSAPQWIKHTHFDFMKPAKVITTLSVLLALAGAALVATRGLNYGVDFAPGTTLTARVDRQVTTEQLRNSVIGAGVSKVTGQSATIQRDTTPGQQGQNFTVKVPELNDAEVKQIGAAIGKLPQGQVLASETVGPAVGKELTQKTIYAVLLGLGLILVYVGFRFDFIMGLGSIIAAIHDVAIAMGLFSLLGLEFTVASVAALLTLIGYSLNDSIIVSDRIRENMKTMRGHSYREIVNAAINQTLSRTVMTSVSTMLPLISLLIFGGPVLRDFSLILLVGILVGTYSSIYIVAPLVVYFEEWRDKNRAAKPVTNS
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Sequence:
MTSARGTPLSIHRPFSTRLFVWRHRRRRLPKHPPEMVSFRREASSTGGQMFGAAHAEDALTAAQRQRGRLRKQKLRTLFSDFEDDSLPSPNSFRTNLAFFALENQRSVTGELSSWFLQYGDVGFKIQREKETQFFPCNSLARQPQLTAEARCKLVSWLIPVHKHFRLSFECCCLSVNIMDRFLASTPIAVDCFQLLGVTALLLATKLVEIGSPSVSHLLSLCCDAFTKEQLYNLERLILLRLNFHFTAPTLAFFLDYFTNCIEADARFKNNCSGTSKTTYVSSFAQKVCELTLADYAFNKYPPSLTASCAMRLASEFLQTYFAGTSSMQSQDNLVDGFTDEGSTVSLQLLESDGASEMDLKDCFLSMMNFNHNLMEECQENMKLLVSLNGIDQCAIDCSY
The following text describes a protein:
Function:
Part of a binding-protein-dependent transport system for a sugar.
Subcellular Localization:
Periplasm.
Sequence:
MFRKIIMILLISILLLSVSSMAQLKGKLEIFSWWTAGGEAEGLQALIDIFHKKYPNVEIINATVAGGAGANAKAVLKTRMLGGDPPDTFQVHAGHELIDTWVKTGFMEPITFLYKQEGWAKVMPKGILDIVSYKGDYWSVPVNIHRANVLWYNKKIFEENNLTPPKTFEDFFKVADALKSKGITPFALGTKDGWEAAHVFETVLIGKLGAEGYKGLWDGKTKWSDPRVTDALETFKKMLTYVNSDHSARTWDEACALIVDGSAAMTIMGDWAVGYFYAKGFNDFGWVLAPGNAGIFDALSDSFGLPKGAKNRDNVIAFLKVLGSKEGQEAFNLKKGSIPARTDVDKSKFPPYQRSCMEDWLKHKIVPSVMHGAAASEGWVTEFKDVISLFVVRPDVKTTQKALVNVAIKNGVKQ
The following text describes a protein:
Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Sequence:
PRLYTSRFDPYSAGIRFVLGAKGIDYEYAYVDVHNKPEWYKEVNPTGHIPCLETGDEVVSETSVIYDYLEDRYPQVKTQPTDPYKKAQDKIFVAHTKEYLTPKITGCVKNPNDNLEEVTKVLKIIDGIMGKRGTDYLGGASPNFADYFLFGWVELLPALKGAHDLKFELDKNEYSNYWAWVMRMDKDKNVE
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDVDDLLVVASDGGLSALLHPLVILNISDHLTRRRAEAKSHNVTAYGALFGKQAGRVVEIFNSFELLLADGIWDLDFLNTRTEAFKRIFKDQDCLGWYATGSHVTADHLALHRQLLGLNEAPFFLLLDDQAQATREQLPITIFETIVELKDDEQHIHFAPTPYKLASEEAERIGVDHIANVSASAVGGQISAVRQQMQTHASALLMLQERIDVICDFLADIDAGKVQPSPALLRNIKGICSRLPVSQDPRLRAALLMESTDTETVNLLALMTQACDAIKQLTGKMQTIHPGAGKTHFASMMM
The following text describes a protein:
Function:
Has a role in the initiation of DNA replication. Required at S-phase checkpoint.
Subcellular Localization:
Nucleus.
Sequence:
MDKGERDLLEERSKTLRVELKVWEKDFQNNNQGRKAAREDIKANPDIASKYKEFNKVRDILAGKISHIPPSAPKATPRKRRHEENHNETPQKRLLVDRTPSKNTMLPWDVDPYHSPSIMRNLFATPSKKMAIGPTPQKDGQVLGLFDLDPDSAADSPSTAHGTAGKLAATQSTPRKTGMTPGSTRAIMHSNTPSSRRTLLFSTPSKNKTAHDHGSNTPSSVSKLHFNTPSFLRRDSQRIRLPAVDENEEDPPDSPEMVRGPQRPMIKSLSSMLAGLRKMEEDAADDDLEALNQMEAEMANTSKSIPKPKPRLQETDSSNIPASKPPAKDSLPEDTSVVDSQPRELLGGFDDEAKYDSEPEEATNAHTSTFKKKGQKRTTRRVNLKPNRTKPSQPMPPTNHYDASESEDELALPDDHLETIPETQLDDEIPRPEDDEFPQPDEFLPDGRNFDSDSASEYTASEGGTRYRRPDQDKTKKSREVNKEGKVKKAARKVKATAGSLQNFKRLKLRNSGAKGGPGVGSRFRRRK
The following text describes a protein:
Function:
May be involved in the asymmetric conversion of racemic 5-substituted hydantoins to the corresponding L-amino acids. Catalyzes the racemization via enolization of D- and L-5-monosubstituted hydantoins.
Sequence:
MHIHLINPNSTASMTAQALESALLVKHAHTHVSASNPTDTPASIEGGADEAMSVPGMLAEIRQGEAQGVDAYVIACFDDPGLHAAREVAKGPVIGICQAAVQVAMTISRRFSVITTLPRSVPIIEDLVSDYGAERHCRKVRAIDLPVLALEEDPQRAERLLLKEIEIAKAEDGAEAIVLGCAGMSSLCDRLQKATGVPVIDGVTAAVKMAEALLGAGYATSKVNTYAYPRIKAAAGHKVCA
The following text describes a protein:
Function:
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
Sequence:
MATGSTAYTWLDDALETIQRAHWHRHPQIITQGPGPEIKLEGQRLVNFASNDYLGLASHPHLKTAAIKAIAEWGTGSTGSRLLSGHRQLHQDLEQAIARWKGTEAALVFSSGYLANLGTITALVGKRDLILADEYNHSSLKRGAQLSGAKVINYDHGCPEVLTDLLMKHRDNHRRCLILSDGVFSMDGDLCPLPQLVAIAEEFQSMLLVDDAHGTGTMGKMGTGCREHFQLPVGDWIQVGTLSKALGSLGGYVAGSASLIDFLRNRAATWIYTTGLSPADTAAALAAIQLIQREPERIVQLQLNVDYLATGLESLTKLNFRRSPINSPILWVGAANPAMALEMAKHLREQGIFAPAIRPPTVPHSRIRFSVMATHSPGHIDQLLEVLDHYYPN
The following text describes a protein:
Function:
Negatively regulates the pheromone-response pathway. Acts as a structural mimic of the G protein beta subunit thereby interacting with gpa1 which then inhibits gpa1 signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
MDNCVNSFEDQKDDLVHKKKSQNFGYVCGSINLGTNVIAQSPTKPLNFFHSSRWSPDGSTILSLTEDQCLNCWNVPFSDLSKKADGPLNFSKHLSYKYQSPETVYSYSWYSRMKLDDPSSNLFAVSSRDQPIKLINFTTGKNKASYHMIDHQERYQGSHCLQFTNDGEYLIAGDKNCLHHFNIRTGCKEPVMTTVTHGYKVPLWEFSLKGIQSCFSLNPMDSKTLAVGTYSNRVGIYNDCGRRPCQLEFSIERGNGVTHLQWCEDGEKLYVGSRCSDKIEVWDIRYVRDMVYALEGHRGDTNQRILFDTDKKDEILAGGTDGSIRRWRNKDLVEETHVTGNYDLTVNTVQANPINMQIKCVCYGNRIYKYEKDESEEEDESKEKDLWTGTVSALQVWMD