lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Subcellular Localization:
Cell membrane. Nucleus, nucleolus.
Sequence:
MAAHKPVEWVQAVVNRFDEQLPIKAGQQSTHTKVSTEHNKECLINISKYKFSLVISGLTNILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFIHTYREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLQETVFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQTPQTDMADCAEKLFDLVDGFAESTKRKAAVWPLQIILLVLCPEIIQDISKDVVEETKINKKLFLENLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPTKPFSRGNQNADVDLMIDCLVSCFRINPHNNQHFKICLAQSSPSTFHYVLVNSLHRIITNSTFKHGLGTASALDWWPKIDAVYCHSVELRSMFGETLHKAVQGCGAHPAIRMATSLTFKEKMTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSNMPEIAQEAMEALLVLHQLESIDLWNPDAPIETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQSDRSSCHFLFLYGVACDVSSGGGASQISLDHEELIRTCTPGASLRKGKGNSSMDSTVGCSGTPICRQAQTKLEVALYMFLWSPDIEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHTKWEQATKLILNYPKAKMEDGQVTESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQHRGNAGLATYSPPMGPVSERKGSMISMVSTEGNTETPVSKFMDRLLSLMVCNHEKVGLQIRTNIKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLNDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNLVHAIQIKTKLCQLVEVMMERRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQATDEDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQAGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLEPLLRTVITSMEWQHVSFEVDPTRLEPTESLDDNQRSLLQMTEKFFHAIINSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPASDSVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLNIFYQAGTSKAGNPVFYYIARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHAGPSNRFKTDFLSKWFVVFPGFAYENVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDSPGKLAEHIEHDQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTRVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSNGSCSSTSFSSEHLHLILEYPHFNQGIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTLLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQKFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKGLESCLKGPDNYNSQVLIEATVIALTKLQPLLNKDSPMHKALFWVAMAVLQLDEVNLYSAGTALLEQNLHTLDSLRVFNDKSPEEVFMEIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPIIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDVSMENVPMDTYPIHHNDPSCRTLKENQPWSSPKGSERHLAASYPTVGQTSPRTRKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAENDYEMETQRISSPQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEEASEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPASLPCSKSAVFMQPLPHSGIDKENVELSPTTGHSNSGRTRHGSASQVQKQRSAGSFKRHISDDVCSAIYVSDFHGKLCCGIVVRIRGKNKQNPAGGVWS
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAKDNEAIAINDAVHKLQLYMLENTTDQNQLFAARKLMSRSDYEDVVTERAIAKLCGYTLCQRFLPSDVSRRGKYRISLKDHKVYDLQETSKFCSAGCLIDSKTFSGSLQEARTLEFDSVKLNEILDLFGDSLEVKGSLDVNKDLDLSKLMIKENFGVRGEELSLEKWMGPSNAVEGYVPFDRSKSSNDSKATTQSNQEKHEMDFTSTVIMPDVNSVSKLPPQTKQASTVVESVDGKGKTVLKEQTVVPPTKKVSRFRREKEKEKKTFGVDGMGCAQEKTTVLPRKILSFCNEIEKDFKNFGFDEMGLASSAMMSDGYGVEYSVSKQPQCSMEDSLSCKLKGDLQTLDGKNTLSGSSSGSNTKGSKTKPEKSRKKIISVEYHANSYEDGEEILAAESYERHKAQDVCSSSEIVTKSCLKISGSKKLSRSVTWADQNDGRGDLCEVRNNDNAAGPSLSSNDIEDVNSLSRLALAEALATALSQAAEAVSSGNSDASDATAKAGIILLPSTHQLDEEVTEEHSEEEMTEEEPTLLKWPNKPGIPDSDLFDRDQSWFDGPPEGFNLTLSNFAVMWDSLFGWVSSSSLAYIYGKEESAHEEFLLVNGKEYPRRIIMVDGLSSEIKQTIAGCLARALPRVVTHLRLPIAISELEKGLGSLLETMSLTGAVPSFRVKEWLVIVLLFLDALSVSRIPRIAPYISNRDKILEGSGIGNEEYETMKDILLPLGRVPQFATRSGA
The following text describes a protein:
Function:
Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNESVESITAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANSMTSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKNITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQNHYTVHGLQSGTKYIFIVKAINQAGSRSSEPGKLKTNSQPFKLDPKSAHRKLKVSHDNLTVERDESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGLAYKSAPKHEWIGKNSASWALCRCHNTWVVRHNSKEIPIEPAPHLRRVGILLDYDNGSIAFYDALNSIHLYTFDITFSQPVCPTFTVWNKCLTIITGLPIPDHLDCTEQLP
The following text describes a protein:
Function:
Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.
Miscellaneous:
MISCELLANEOUS: A variable cleavage site between the alpha-subunit and the spacer peptide was observed: Ala-194 may be a part of the alpha-subunit or the spacer peptide. This step of the maturation process may not be very specific; MISCELLANEOUS: AHL-mediated signaling mediates quorum sensing in many species of Proteobacteria, regulating hundreds of genes, including many that code for extracellular virulence factors.
Subcellular Localization:
Periplasm.
Sequence:
MGMRTVLTGLAGMLLGSMMPVQADMPRPTGLAADIRWTAYGVPHIRAKDERGLGYGIGYAYARDNACLLAEEIVTARGERARYFGSEGKSSAELDNLPSDIFYAWLNQPEALQAFWQAQTPAVRQLLEGYAAGFNRFLREADGKTTSCLGQPWLRAIATDDLLRLTRRLLVEGGVGQFADALVAAAPPGAEKVALSGEQAFQVAEQRRQRFRLERGSNAIAVGSERSADGKGMLLANPHFPWNGAMRFYQMHLTIPGRLDVMGASLPGLPVVNIGFSRHLAWTHTVDTSSHFTLYRLALDPKDPRRYLVDGRSLPLEEKSVAIEVRGADGKLSRVEHKVYQSIYGPLVVWPGKLDWNRSEAYALRDANLENTRVLQQWYSINQASDVADLRRRVEALQGIPWVNTLAADEQGNALYMNQSVVPYLKPELIPACAIPQLVAEGLPALQGQDSRCAWSRDPAAAQAGITPAAQLPVLLRRDFVQNSNDSAWLTNPASPLQGFSPLVSQEKPIGPRARYALSRLQGKQPLEAKTLEEMVTANHVFSADQVLPDLLRLCRDNQGEKSLARACAALAQWDRGANLDSGSGFVYFQRFMQRFAELDGAWKEPFDAQRPLDTPQGIALDRPQVATQVRQALADAAAEVEKSGIPDGARWGDLQVSTRGQERIAIPGGDGHFGVYNAIQSVRKGDHLEVVGGTSYIQLVTFPEEGPKARGLLAFSQSSDPRSPHYRDQTELFSRQQWQTLPFSDRQIDADPQLQRLSIRE
The following text describes a protein:
Function:
Component of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). Binding by the elongator complex stabilizes microtubules and promotes their growth. This induces central spindle asymmetry, promoting polarized signaling endosome trafficking during asymmetric cell division and cell fate assignation of sensory organ precursor cells. Involved in protein synthesis-dependent long-term memory formation, probably as part of the elongator complex.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During asymmetric cell division of sensory organ precursor cells the elongator complex preferentially binds and stabilizes microtubules on the anterior side (pIIb daughter cell) of the spindle.
Sequence:
MRNLKLRYCKELNAVAHPQHLLLQPELNGGASDIYFVVADNKIYAVQESGDVRLKVIADLPDIVGVEFLQLDNAICVASGAGEVILVDPQTGATSEGTFCDVGIESMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPLDAELDPDQQFVNVGWGKKETQFHGSEGKQAAKQKESDSTFIRDEQELNQDVSISWRGDGEFFVVSYVAAQLGRTFKVYDSEGKLNHTAEKSANLKDSVVWRPTGNWIAVPQQFPNKSTIALFEKNGLRHRELVLPFDLQEEPVVQLRWSEDSDILAIRTCAKEEQRVYLYTIGNYHWYLKQVLIFEQADPLALLHWDTRCGAEHTLHVLKESGKHLVYRWAFAVDRNNSIVGVIDGKRLLLTDFDEAIVPPPMSKIVLKFETYINAFISHGTSLWVYTCDRKIYLNEHIHTLGKELQKPIMLMPDAELSGLHLANLTHFSPHYLLATHSSAGSTRLLLLSYKDNDNKPGEWFYRVHSSVRINGLVNAVAVAPYAMNEFYVQTVNNGHTYEVSLKADKTLKVERSYVQLHEPADQIDWVIVKGCIWDGYTGALVTLRNQHLLHIDGYRIGEDVTSFCVVTNYLVYTQLNAMHFVQLDDRRQVASRNIERGAKIVTAVARKARVVLQLPRGNLEAICPRVLVLELVGDLLERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQWLCLFLSELQNEDFTKGMYSSNYDASKQTYPSDYRVDQKVEYVCRLLEQQMNRFVSRFRLPLITAYVKLGCLEMALQVIWKEQQEDASLADQLLQHLLYLVDVNDLYNVALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACGEQHYEEALEYIRKHGLYTDGLAFYREHIEFQKNIYVAYADHLRAIAKLDNASLMYERGGQLQQALLSAKHTLDWQRVLVLAKKLSEPLDQVAQSLVGPLQQQGRHMEAYELVKEHCQDRKRQFDVLLEGHLYSRAIYEAGLEDDDVSEKIAPALLAYGVQLESSLQADLQLFLDYKQRLLDIRRNQAKSGEGYIDTDVNLKEVDLLSDTTSLHSSQYSGTSRRTGKTFRSSKNRRKHERKLFSLKPGNPFEDIALIDALHNHVTKIAQQQQPVRDTCKALLQLANAADADPLAAALQREFKTLLQAVDAALDEIWTPELRGNGLMADHLTGPNVDYLALQKEQRYALLSPLKRFKPQLIMMDWQHEILQ
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nuclear body. Cytoplasm, cytoskeleton. Cell membrane.
Sequence:
MGASGKWVKSIIGLKKLEKDEIEKGNGKNKKWKLWRTTSVDSWKGFRGKHRSDSDGVDSSTVYSAAVATVLRAPPKDFKAVREEWAAIRIQTAFRGFLARRALRALKGIVRLQALVRGRQVRKQAAVTLRCMQALVRVQARVRARRVRMTVEGQAVQKLLDEHRTKSDLLKEVEEGWCDRKGTVDDIKSKLQQRQEGAFKRERALAYALAQKQWRSTTSSNLKTNSSISYLKSQEFDKNSWGWSWLERWMAARPWETRLMDTVDTAATPPPLPHKHLKSPETADVVQVRRNNVTTRVSAKPPPHMLSSSPGYEFNESSGSSSICTSTTPVSGKTGLVSDNSSSQAKKHKPSYMSLTESTKAKRRTNRGLRQSMDEFQFMKNSGMFTGELKTSPSSDPFVSFSKPLGVPTRFEKPRG
The following text describes a protein:
Function:
Dynein-attachment factor required for cilia motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm.
Sequence:
MFPWPQAFSESKVAALLLIRQPYLLSMSDSVMMSCTIEQLPAGSSATGGTAASWNRIKLSKELASAVQDDARRKAIDSAKKRAVSQHVDYETFQAMVSVAHLKPIERDEWYRRPAELHSSPAWKFSADGSLSGNALTLNPSEGNCATEEQLSGLINEPKNAEEFQKRWRSLKGSAEDRLRLFMSIGPEKLLPLFKVEIRPALLGEIFSVLSECWDTDTDRRALGNPSSDGDTTNALEKTMGALSIQRPSALLREEGEANGKRSGNASETDRDTSVAAPQRQELTCAFPGLDDSFRKKKGGGTLQIGMGADAASLASEAADGAFESTSVQESIPAGSPEDAAESQQHVGSVASGESQKTELQGHERRADPQAGDCVEKILNILTALSKSGRFSLTLRLLSNGHKKDMRSVFEKLRVATIKQGAADALDRLSSIEALFLQ
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MSLEILYHAIKSEINSHFTATVATVHYLLIQHGFKCVALGEKPPEKVDTRLTDLLPPSWNENTYKCSLVYWSPSLEFYLFLKIFHMKEFALVHLLKNENVSMKDMDVQYSVYFSDDFSSFQSLFQRPNALLDVIDTQLIRPSLVPLKKEVAVQNLVKQEEEVISTPQTTSRPSNSATAVSLPCGRCDLDPLCPCTSGGASGMLFDPLRNFMHPPPPPPFLRPCPDNDNDPSRIPLGSVPPGARFDPIGPNQQDPRRTWEPDPDHLKMPSFNDRSNL
The following text describes a protein:
Function:
Involved in cuticle formation and ensures cuticle shedding during larval development. Plays a role in maintaining the hypodermis. In association with vps-39, may play a role in vesicle tethering.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm.
Sequence:
MPNDRVAPLPPNFVYSPHDKFYYAPATCNSMHYTTASYISAFIEFLVMGTGAICFYVMSHKSDSIGKWLFYIQAGITVLSLLTSALMAFGLWKENPQMLGSKLKFIEFIICFLLIWAVISIVCMAFGIQFTRQVFGIFGKVHRIEQDYGPIWPFNIAVVSFFTAAIAIWTRIIIQGAADYLYDKAYFADKQNVELRESSKTR
The following text describes a protein:
Function:
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Sequence:
MRSQLVLLAGTNGWGKLYWSPGFCPCTCIPSKLCTIAGTGISNQHNAGAGGWRPAVFKMAELDADLDHIIPSVLPPFWAKLVVGFVSLLCFARSYDGDFVFDDSEAIVNNKDLQSDTPLADLWHHDFWGSRLSSNTSHKSYRPLTVLTFRVNYYLSGGFHPVGFHVVNILLHGGISILMLDVFSVLFGGLQYSSKGRRVHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCRAFKETGNKEGTHSSTFWVLLSIFLGAVAMLCKEQGVTVLGLNAVFDILVIGRLDILVAVRKVLRKDKSLESTGMLKNGGLLFRMALLTIGGSTMLYIRWKIMGTGPPAFTEVDNPASFADSVLVRAINYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCMLLTFGFGTLSRHTKKKKPVAAIILGILLINALRCVIRSGEWRSEDRLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVMKPEHSLAWNNMVILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDPVAVGTKENYSLLRRKLEQMQKKDV
The following text describes a protein:
Function:
Critical for B-cell development.
Subcellular Localization:
Endoplasmic reticulum. Secreted. Note=In pre-B cells, localizes predominantly to the endoplasmic reticulum.
Sequence:
MRPGTGQGGLEAPGEPGPNLRQRWPLLLLGLAVVTHGLLRPTAASQSRALGPGAPGGSSRSSLRSRWGRFLLQRGSWTGPRCWPRGFQSKHNSVTHVFGSGTQLTVLSQPKATPSVTLFPPSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLSLTPEQWRSRRSYSCQVMHEGSTVEKTVAPAECS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPSSPYGANASTSHQHVKQNAHPSAPLSRTSPSLPPKPTVAMNGNGHYHAAPTSVALDKNKQTATSSHNLMIGVPPAATPNLSLAQSRPPDSKQSSDADGHPVFLSSAKGKQKQVDPIHIPLAQLEQELPLEEADLISLAALVERLANFGYEALQNLAETLPSLPSSSKRAKIFNTALNVRKQFIKLLVLARWSKDISDLQKSRNIIALLSEQQWQHEDVFAGLTDIRKILPNARMRNADLPTAIDVLHTGTYRRLPASIKQMAVAPKPFTDQQALLIVSRLEDALRTRMACRELVPAPLSNYTIHDGKVHFHVPGLFQAQLTASGSAQHELTPSSSDDRWWLLDLTFDVIASGSCAASCNRAFPRKPKRAYRERLRVWGDQQLSPVIQSDGVDESNARPLDIAADKTEQGTDVQIAPEKPTDAPTVNEANPAITATHHDDSLMPTAPVQRDAPLSRLFAFLQERALHYQMDILQHQAYELCRLNWGSNLRIETAERPRNLTVHYWTQAQGAAGATQRVESAAAGGSVQITIVDLPDTPGATETLAALFDGDDDQSSTTHDTASLTTVKRRGLQVTWDADRSILADAQSNNLAISPHSLDIEALLSSVIKQHTLALLRNLQRRILVSDHALSRLLRPEDCTLCLEHIQRQGDEFSTATETTTFNFLQIDLHASQRPRTAKSKPNPKPEQRSASCLAPLRLSVDPVTGRLLLDSEPAQSTTDLSSEQTSQQAASFTASILTTRPNYARLAEASDRINESIDALLDVLYRLDVFARVQEWERMASYLGLRSVRKLALRPQDLAKLGASTLASAEAAPQLFLPLRQSFGGYFLALQPSELAGVSIALVYVVQVMDPTGTPALSVQSIEWLDRAKIAAAASKVGSSGEDVGQEFVATEAGTKRKAPPGVQGETNDVDANFGSSELTIEELADVHSYCIALVSYFRVEQQLRMRGLPYLHVGSNTMRSSPPCKRQRRQQTADARDDGLFGEDASGGTASSDDEAFAGPAGVAGVAALVPSLCLRSIDVLGPSKSHLAKPNISLRVRHWDDDEKLCVEMRIKLRMKSRQFRTLHEVVALAASSDQQSTCALTWIDFDREASLLTLTTRDLDNCMSIFHTHWERVMRMVQLTREVLNASRAWQQRALRLRRSCKKPGERVELCRFELDSVVFSYGSIKVDGLEAKLLVRVRWQDAKLEMQAFSPIGVTQSGGYILEFGSMRSVQVEALDQDAQLREDGVSRWFDETHCLANPHKVMALELRRTVNVAARSAAMHAMLQPQAERIVWRGFLELLQHTLPLVREMAPLVDKCLTHAHVPEVEIKSATWFRFRFQDRYAIDVRLATRSRLVVSDASRALFASEVRTSESESESETTDAVPLDAVFGGSQLLNDLLDATTLARKCSKPKTRIAAQLSSAQFGPIPNIEHVLRSVHAKLDAITWIDARDHRSSAARLRVYELGRALLISLPSASHPNAQAAYHAIAHLVPLLIDRVEAQLARSTP
The following text describes a protein:
Function:
Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by emb/Crm1 (By similarity).
Sequence:
MTTYATDSQGKFIPATQRPDGTWRKPRRVRDGYVPQEEVPLYESKGKLFAQKPSLPPGLPPEMAQKAREKREKEQRKAAARPAQNPVPGLLILHEDNKANQRQAKPANAKPKKKAVELPDVLLEQKQKEEQKAASRQQAQDQRNSKQQQSQNQSKPLDDVTKAVQDLQLGTASGADGHSDLSKKLRKLRKKIREIEVIEERLRASDGPRPDKDQIEKAKRKAEILKEIEELERGGGHK
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence:
MPLENLEEEGLPKNPDLRIAQLRFLLSLQPQRPDPAARQELMAAIKEHDMAPYYESLCKSLDWQVDSDLLNKMKKANEDELKRLDDELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEAALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALDRPDLREKVIKGAEILEVLHSLPKVRQYLFSLYECRYSVFFQSLATVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMADAFGVCVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM
The following text describes a protein:
Function:
Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MAPTLNVKEDSGNQSSWNTLLPDFPKGPLSKYRKKASFNWKEMAVFLDGEDIIQLKNRIFSALESDPFFAHHPGEELSREKYQELTFLRCKRLFEYDFLTQQEIMENPLKILNMVICIGMYDWSPCLQFFLHCGVFGGTILSASKRFADFMKKIYNMEIFGCFALTELSHGTNTKGIRTTATFDRNTQEFIINSPDFEAAKFWVGNMGKHATHAVVYAQLYTPDGQCQGLHSFIVQIRDTKTLLPMPGVMVGDIGKKIGQNGLDNGFAMFHNVRIPKENILNITGDVSPEGKYSSSFKDVKERFSAALGSLSSGRILITAVSATNLKLALSIAIRFSATRHQFGPTDEEEIPVIEYQTQQWRLLPYLAAAYALDYFSKSLFENFVEFYAGLLTKQRSQRQADLGREIHALSAASKPLSSWTAQQAAQECREACGGHGYLAMNRLGEIRNDNDPNCTYEGDNNVLLQQTSSYLMSWMNCIRNKVPFESPLGTVNFLQDYHHIIGWKFKANSIDDCMDSSVPLAAYKWLVCYLLRESDLKLRKEKQSGHSDFEAKNNCQVYYCRSLAIVFIEQTVLQRYHDYTHDPNVPSTLQPVLKNLSALYGLWSLSKHLAVLYQGGYVSGEQAGRFVQNAILELCSRLKDDAVALVDVFAPPDFILNSPIGKASGEIHRSLHRFLTLTVLLCFDHLRTTFQEVLPRFHTIHNRVSSAQQHSILGLLKPSDSLTCINCSTDFEQCETSRWDFI
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSTFELQLTLFQTSQPPSSSSSSSSSSSSSSSSSSSSSPPPCSPSNRCNVFFKICLTHQQPVMKLKNFPEAGPGGYDCTFGSTVTDVLWRNNSSNMHHTVRLPISYKWTHKFALIIEAYHMDDDNNHNIQQGLLLKLILLKNVTSEQGWITESFHNGSTKLDYRYRLVCLHNIYGPFCSNSCVARDDSLGHYRCLRNGTKSCLQGWTGEWCLNGVLTASCDRCIHGKCTEPNTCQCSSGWMGAHCDECIPDPACVHGTCTAKTKCVCKQGWGGPLCNQDLNLCAKKPCLNGGTCMHRGVGYYHCVCPNNFSGTNCERPIDDCNVRANPCSGRGRCLVSRRQYRCTCQEGYDGYNCQDEVDECASHPCFNGGRCIDALHSFQCICKPGYEGPTCETQSKRCTPNPCLNGAECLQLAADNFECRCRHGYHGPLCQDHVSRCAELPCSNGASCVDLFNTYKCLCMPGFSGDNCEVRKDLCAGSPCLNGGMCISATDSVLCRCLSGFHGERCEF
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MEGGRGGGDGNFLPNSNFGVFSDSAMDMDFMDELLFDGCWLETTDGKSLKQTMGQQVSDSTTMNDNNNNSYLYGYQYAENLSQDHISNEETGRKFPPIPPGFLKIEDLSNQVPFDQSAVMSSAQAEKFLLEESEGGRRYWIAPRTSQGPSSSVKERLVQAIEGLNEEVQDKDFLIQIWLPIQQEGKNFLTTSEQPHFFNPKYSSLKRYRDVSVAYNFLADEDSKESVGLPGRVFLKKLPEWTPDVRFFRSEEYPRIKEAEQCDVRGSLALPVFERGSGTCLGVVEIVTTTQKMNYRPELDNICKALESVNLRSSRSLNPPSREFLQVYNEFYYAALPEVSEFLTLVCRVYDLPLALTWAPCARQGKVGSRHSDENFSECVSTVDDACIVPDHQSRHFLEACSEHHLLQGEGIVGKAFNATKLFFVPEVTTFSKTNYPLAHHAKISGLHAALAVPLKNKFNSSVEFVLEFFFPKACLDTEAQQDMLKSLSATLQQDFRSLNLFIDKELELEVVFPVREEVVFAENPLINAGTGEDMKPLPLEEISQEDSSWISHMIKANEKGKGVSLSWEYQKEEPKEEFMLTSGWDNNQIGSGHNNFLSEAEQFQKVTNSGLRIDMDPSFESASFGVGQTLLGSRRPGEKRRTKTEKTIGLEVLRQYFAGSLKDAAKSIGVCPTTLKRICRQHGITRWPSRKIKKVGHSLKKLQLVIDSVQGVQGSIQLDSFYTSFPELSSPHMSGTGTSFKNPNAQTENGVSAQGTAAAPKSPPSSSCSHSSGSSTCCSTGANQSTNTGTTSNTVTTLMAENASAILKRARSEVRLHTMNQDETKSLSRTLSHKTFSEHPLFENPPRLPENSSRKLKAGGASKVKATFGEAKVRFTLLPTWGFRELQHEIARRFNIDNIAPFDLKYLDDDKEWVLLTCEADLEECIDIYRSSQSRTIKISVHEASQVKLGGSFGSIGLGPSL
The following text describes a protein:
Function:
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. Colocalizes with actin.
Domain:
The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.
Sequence:
MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC
The following text describes a protein:
Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDKAVDAAIKREKVKEAATALIAYHKTKKDANEMLFGEPLKVQLQISVWKITTKKSTTHKLKLPHRPHAGSLSVCLFVKDEPKMDSDRCQVHYKDKISSKGVTNVNEVIPLKMFKKEYIPFEARRKMAKSYDLFLADERIFRLLHSSLGKEFYKRNRYPVTVNVEKADLKKEITETIEAAYLILTHRGSCSTVAVANIGMSAKDITDNILSAIASLKTIVPGGWSNVKSIFVRTEKSVSLPIYTSLVHEEWEQSEETEIVIDNSDIKKMQKQMRFEAKEAAKKDPQDEEDEDETPKKTLKRTKEETVTPAKLVKKAKQGSIGRASLRKPTPKVGGKKKK