lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTENKLKIRGARHHNLKNIDIDIPKNKLVVISGLSGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLEMMDKPDVDSIDGLSPAISIQQKTTSKNPRSTVGTTTEIYDYMRLLYARIGIPYCTNCGRKISTQSIETICDSVLREFSGKKILILSPIIQRKKGTYEKLFEQIKKDGYSRIRLNGEILSLDEEIPPLDRQKWHNIEIVVDRITTEKSERSRLFEAIQTAIKASKGDVMVASEKSEKVFSQNNACPYCGLTVGELEPRNFSFNSPFGLCKDCNGLGVKMEFDPDLVIPDKTKSILDGAIVPWSGRFSSFRRQALRAVGKKFGFDLMTPINKIKPKHLKIILYGTDDLIDFNYRSKSGDSSWQYTNAFEGVLDNLQRVFMETDSESKREWLKQFMRDTPCNGCNGKKLKPESLAVKINDKGIMDVCDLSIDHCYDFFSTLKLTENEQYIARDVLKEIKERLEFLMNVGLNYLTLNRLSSTLSGGESQRIRLATQIGSNLTGVLYVLDEPTIGLHQRDNARLIKTLNKLRNLGNTVIVVEHDEEVIRNSDWMVDLGPGAGVNGGSVVFEGTVNQILNGHKSVTGDYLKDNSLIMLQDKIRNNSGTLVVEKASENNLKDIDVEIPLGLFVSITGVSGSGKSTLINDILLKALENHFYKSNVKPGTHKKIVGLENIDKVIAIDQSPIGRTPRSNPATYIGAFTPIRELYANTELSKERGYAPGQFSFNVADGRCFACDGDGVKQIEMQFLSDVYVKCDECKGKRYNSETLSVLYKGKNISDVLDMTVYEALNFFENIPAIKRKLQTIYDVGLGYIKLGQSSTTLSGGEAQRVKLASELSKRGTGKTMYILDEPTTGLHFADVQKLLDVLNRLANLGNTVVVIEHNMDVIKNSDWIIDLGPEGGDEGGRIVATGTPKDIAKAPGSYTGKYLKKLVKK
The following text describes a protein:
Function:
Promotes AHA1 plasma membrane ATPase activity by binding to a site different from the 14-3-3 binding site.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MGVEVVNSGGFEVAPAPFEGKPEKNGKLDQGKGDDAPINFGSVGELPKNAEENNNKVVNSDAPKNAAEEWPVAKQIHSFYLVKYRSYADPKIKAKLDLADKELEKLNKARTGVLDKLRAKRAERSELFDLLDPLKSERKGFNTMFDEKRKEMEPLQQALGKLRSNDGGSARGPAICSSEEELNSMIYSYQYRIQHESIPLTEEKQILKEIRLLEGTRDKVIANAAMRAKIKESMGQKDDIQGQVKLMGAGLDGVKKERQAISARINELSEKLKATKDEITVLENELKTVSEKRDKAYSNIHDLRRQRDETNSEYYQNRTVLNKARDLAAQKNISELEALANAEVEKFISLWCSKKNFREDYEKRILQSLDSRQLSRDGRMRNPDEKPLIAPEAAPSKATPSETEVVPKAKAKPQPKEEPVSAPKPDATVAQNTEKAKDAVKVKNVADDDDDEVYGLGKPQKEEKPVDAATAKEMRKQEEIAKAKQAMERKKKLAEKAAAKAAIRAQKEAEKKEKKEQEKKAKKKTGGNTETETEEVPEASEEEIEAPVQEEKPQKEKVFKEKPIRNRTRGRGPETIPRAILKRKKSTNYWVYAAPAALVVLLLLVLGYYYVL
The following text describes a protein:
Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Subcellular Localization:
Cytoplasm.
Sequence:
MSNVYDILKERGYIKQLTHEEEIRELLGKEKISFYIGFDPTADSLHVGHFLQMMVMAHMQKAGHRPIALVGGGTGMIGDPTGKTDMRKMMTKEQIEHNCNCFKKQLAKIIDFSEDKAIMVNNADWLLNLNYIEFLREIGVHFSVNKMLTAECFKSRLEKGLSFLEFNYMLMQGYDFLELNRKYNCVMELGGDDQWSNILAGVDLIRRKESKSAYGMTFTLLTNSEGKKMGKTESGALWLDPEKTSPYEFYQYWRNVADADVEKCLRLITFLPMDEVRRLSSLEGAEINEAKKVLAFEVTKLIHGEEEAQKAKIAAEALFGGNAKDLGNMPTAYIDKNDLNNLLVDLLVKCEILPSKSEARRLIKQGGLYLNDEKVTDMNLVVTEEHVTEDGIMIRRGKKNFNRIVVE
The following text describes a protein:
Function:
Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MSSHPQPVPQGRRAVDARHLSSAANLPLQLRAHTDVGGLVDYHPHARDYGLTHGSLVQPHRRRPSLLSEFQPGNEREPHIRYEHIYLQDASSQSEVEYSEMKRPRLEIGAESLIRHSSHRQALTVGGAEEMAKEHSSSSSIGKIEPISPVSPVPMEADLDLVPSRLSKEELIQNMDRVDREITMVEQQISKLRKKQQQLEEEAAKPQEPERTISPPPSEAKHRSLVQIIYDENRKKAEEAHRILEGLGPRVELPLYNQPSDTKQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQNRVAQRGGGLASAARSEHEVSEIIDGISEQENSEKQMRQLAVIPPMLFDAEQQRIKFINMNGLMDDPMKVYKDRQVMNMWSEQEKDTFREKFIQHPKNFALIASFLERKTVAECVLFYYLTKKNENYKNIVRRSYRRRGRSQNNQQAQQQVNRNNQEEKEDKEKEKEGEREEDKAEGDDKEDGIKDDTSGEDGEEKEPPVTVKGRRTANSRGHRKGRVTRSMTNEQEENTSPLGSELANLEMNESSRWTEEEMETAKKGLLQYGRNWSAIAKMVGSKTVSQCKNFYFNYKKRQKLDEILQQHKIKSEKERKARRKGKAPQNEEASAPSAAEEEEMEGSGVSGNEEEAQEDGEGGANNSSDTESLPSPRSSDDSKVKEEGSARPKTAPNATSSSSSTDKDMAAAETGMDEKPKVEKGDGEQAGVKQEVKTEPGEGASESAGEDKKPPALEVEEGKKEVKKKEHGGKSGAHDSDSSATCSADEVEETESSEKSRPSLLSFSHDGVISSQAQKPLDLKQLKQRAAAIPPILPEVSGRDNRPGLPGKQAMPDALALYQQQITMAHESSQEAKQQQQQQPTKSQHYPAAGDSGSPRVRTRSPGISDREREDGKKNPGADDIRALGLGRPVMSSYLSPRDMAKFSQEQLLHYNPSLASTLQPQDRMAAVRPLHIPEPPPLISSAKPGGSITQGTPVQLHNPSHGSEHGKVPAPGSLALSWVDQRKMGGFPVVKQEQLSPRGASSSSSQAENLSTQDSSTSRGPMPAVQGGSITKGIPGTRVHQDSPISYRGGSITQGTPADVLYKGTITRLINEDSPSRERSREDTPSKGHVVYEGISGHILSFERRPNSKEEGCGDVGAGMKRSYDMMEVGISSRVPPIRDPLSEGLIIRAMPPDRDSPHPQLIRGSISQGIPRDDCQRREVKQMKREGSPSPRGPGHSTDALKSRSHESMVPTVKEGGRSIHLIPPEGVVIGKPKEGSITQGTPLKQEPPGSSKRHDVRSIIASSPRPYSGLPSHLDPRGSDRARYEEAGGKSRPSAVVSAPSSLSRVSPLALSGEQSSRPHHSPVGYEDHKRSSYPPPSHRASPLSGRENSQRAHEGSSKPQQQERKATPTPREMGSTKSPLAVGEHTANLAFERILGLGPDMYRSQMSHLTFDAAALPRGIPIDSAYYLPRHLAPGPGYPHPYPPYLIRGCFPETAALENRQTLFNDYITSQQMHQWPAAAAMAAQRPDLLRGLTPREQSLNLAYSPTPRGTSASPMDRITYIPGTSPGFPSGAYNTSPISPVGASHMSKIQGGSSSAEREREREREREREQRERERERERERDRERDRDREREKDRDRDRERDKSLSHGNVEHAPIWRPGAPEQMSGSSSRPPSHPYSHQSPLSPRPQDSLQQRPSVLHNTSSKSLSNSEHNNPSVLRPPGSARYQGFSGHLQRSGLPGEGYPSGTDPSAKDLSRDGGKSHGRGGLPKHQDLSSSSKSDSKLASPGAGGTYPSPYNQAPVAHLPTSRGHPLLAPESGGGGSSIQSRGGDSGSSASSREKTQNKVMSIQEHELRALAVSAAQQKAFEQLYGSEDRLSPGQQSSSGVKGSQRVVTLAQHISEVITKDYTRQSQQNQIGGQPSLPPGYGYHSSPVLDLTRPPSTPQAQTPTEPNSRYTPEGTSAERGRDRSPPQNKTSPVSLAADGIEPVSPPGAISEPETPGANYPNEQAEQGMGSRSPASSSQPPAFFSKLTESNSAIVKSKKEMIKKISAEAEFNQSQPGTEIFNMPVSTNAGPVSVRSHPPPEASGNTIGLEAIIRKALMGKYDEQMDERSPSNSVNSMAAGGAAAVVPPASADGRSEDPYSLPGKSKGGRSNGRKTKSPGPGLSGGERPSSVSSVHSEGDCNRHTPLTNRVWEDRPSSTGPTPFPCNPLTMGMRLPSGIMPGPSPSPTHPGASAPTQGQTQPRTWEEEPKPLLCSQYETLSDSE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MSSDNFPLLDIPELVTCLQECDFSLATIQNVERPSSQFVITLYKQIIDTFMGVSPDSLLEDSRNFVENGDTSEQEVYDASLVYHDTLKILALNKICYKFFLDIGVSDFNVMDLYKPDPHRTRRFLSAVANYARFREEAMLELDGDQHPDGVRYLEQTDKLLKELRLKFDANNLLHSRVQKYKEFQKSDDLEALESDNKNMESELRHLNQVQETLTVDYERYKAEKQRHLSELETLGYELIELESERDKLRKYSQTDAEVLRKGVRELSLLLEQQQVQLEKLEQKQKNLQISFETFQASTQELYEVLQIVSTDLQDSHLKESTLLDAKHKLMQNHKNLNNLLSAGIMAKITLLQEQLDSQKRKLAELELNTQAKESENSATLKRLRKQHTDDVLPEVRNIEQRYKTKVADTITNYESQMRNIKVDFDNEVALIENECSLLFNHIKNYMTTIGEKLG
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MYLTLLNGTGFVFNVDDYMELRSKHRIMGAPVGTANTKGWSPNQSTLPVELSKFETQLLLDENIAKLVDKSKDLKAKPTAEKLEECKADFESRLLGQEEALKTEKLRETERYMDKILTGKRKKLLKQGKNELAAALTDKDVLLEMSVNFKFDRQNALLEVHCEHPTDHSAQIVTGPIVHTNSLKYRVFKDLWRRGKYVTSGDAFGADFLVYPGDPMIYHASHIVILHEQPVIKPLELIAKVRLSVIVNKSCVFAYEMENNEEEIHYQTVAWCNLGK
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVNAARKNLMSRRNHKERAQPLHRARLGHLEKHKDYVHRARDYKSKQERIRKLREKAAFRNKDEFYWGMVKGKTKGGVAIGERGFEALSTEVVKLLKSQDLGYIRVQIAKDEKAVTKLRAELEVTAPASSATEEWSAASELAEVEKLAEMGIVLSPALTRKKGKGKGKAPSEGHVVFVDERSDFENYGNEYEEEEQQGTEEEQIDLGWEEPQPVKKRKSKAVELAKEEFDEEAAAQEAREYRLQLLSDLSAHLNRLKLLRQAEAKLETTKGLMGKGAARKIRDHGWVEDESQPEDRNGDRKKWQGKIWKWKMERRK
The following text describes a protein:
Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPNMYESNPVTPASSSAPPRCNNYSANAPK
The following text describes a protein:
Function:
Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MKGDKELVGTLKGFDVYVNMVLEDVTEYEILPEECRITKLDRILLNGNNIAILVPGGSLDVE
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MSPVLMPSKPAISYSHVTKSFGSLKAVDNVSLDIAEGEFVAIVGGSGSGKTTLLRLANRLIEADLGTITVEAEDVQNIDPVALRRRIGYVFQSGGLFPHLSVADNIGITPKLLGAPAADIAARVDELLELVQLDRAAHRDRLPEALSGGQRQRVGVARALAAKPRIVLMDEPFGALDPLTRDALGDDYRSLHRRLGLTTVMITHDMTEAILLADRIAVMRGGKLLAQGTPGELSTSTDAYVLELLRTPRRQVERLNALLPQSGAA
The following text describes a protein:
Function:
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity).
Sequence:
MLSGGGGDADLANAAARGQVEAVRQLLEAGVDPNRLNRFGRRPIQVMMMGSARVAELLLLHGADPNCADPATLTRPVHDAAREGFLDTLVALHRAGGRLDVRDAWGRLPVDLAEERGHRDVARYLRATAGD
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHGRRANRAQEEEQARLQKVKELIPLVNNLIKKKKTNNYDKEYIDRTSLILMKCPYLQTLWNYRREYFEYIKPEYLKGKKEIEDEKCDMTKTSEELKKILKDENNMVEDILNTFNKCNELWFHKLWIIKYGLKDNLIDMKDLLNELEYCKRSFYKDDRNYHCWNYRSYIISCIHIIHKKLNNMNKENKENKEKEKNLDETNKTHQTHQTHQTIQSNQSNQSNGCFNFDVYETNYKLSKMLIENNFSNFSAWFLKYSLKKSIIDTNNELNLIKNAIFTDPFDQSLWEFYKWFLFQNGNDKEEILFILLNNNTIYLFFPNLINLNISKCICYDNNNKEIKGSWDKHIIKINNSNNINDSNNKESFVFSFTFDKNYLLLGNIPYIKFVLYYYKYNIYVPHQIHYEQNILKDIYRLYNNSSKENNKYEHSIIYQIDITKISKCQLFNILLDNNQYNRKGIYQFSNNIDDNNDQNKIYYNFYKYINSSNILLNISTNMDLHLLNLELEQINELLLLENDCKFALYTKFEILKRIEHFEEALKVLDYLKQVDFLRLEYYKDQETEILIKKRIHDYYETSEKGNNNEMLDLTHMNIKSIIYPLMIEAFFILKIDLSNNSISEGYNGKGTLNFLYNLRELCLNNNKLKNFIFLMKNLYNLKLLEKLDVSNNHLVDMEQDLDQYEFVILPSLKYINISNTNIALLLNEKYKHKNILNTYNIVRHNNTVVLSKL
The following text describes a protein:
Function:
May be involved in cell wall synthesis. Catalyzes alpha-1,4 glycosidic linkages and generates Lewis-a epitopes.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Sequence:
MPMRYLNAMAALLMMFFTLLILSFTGILEFPSASTSMEHSIDPEPKLSDSTSDPFSDVLVAYKKWDFEVGCARFRENHKDAILGNVSSGSLQEFGCGKLKMKHVKVLVKGWTWIPDNLENLYSCRCGMTCLWTKSSVLADSPDALLFETTTPPLQRRVGDPLRVYMELEAGRKRSGREDIFISYHAKDDVQTTYAGSLFHNNRNYHISPHKNNDVLVYWSSSRCLPHRDRLAKSLLDLIPHHSFGKCLNNVGGLDSALSMYPECVAEHNAEAKWYDHLHCAMSHYKFVLAIENTAVESYVTEKLFYALDSGSVPIYFGASNVQDFVPPHSVIDGSKFGSMQELAAYVKRLGDDPVAYSEYHAWRRCGLMGNYGKTRAVSLDTLPCRLCEEISRRGGKNAGV
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MSLAQQRLLRLSSIASSSTRTLHFTALRAWQGFENERHYEPGEDALKRTWHGLTYDFRRWKRRYQEARNDAFKRRHPIAHMKHSVMDHEVFPYRAEVLIIGGGLSGSSTAFWLKERFRDEDFKVVVVECNDKFPSSSSMLSTGSLAQQFSQPEHCEMSQFTAEFLRHSGKHLRVLDSEPPSVDLLPSGFLHLATTEESANEMREHWKLQLDKGARVSLLTPPQLREQFPFLNVDDVVLASIGLENEGSIDTWQLLGAIREKNLTLGVQYVKGEVEGFEFERSPTSPEVHSLIEDADEADEDKWKRQRVIGVHVRPQMTDASARPIRAHLIVNAAGAWAGKIAKMAGIGSAKSGMLAVPVPIEGRKRTRFVIYAPDVPVDMPFLVDMEGRLHCRQMDAGHTYVVDLIPTPEEDKAIDHSDPSVDYDIFYEKIWPQLVKRTEGFSTAKIKSAFTVLEDVNTFDSAPVIGEHPLYTNIHTMAGFGERSAMHSIAAARAYAERVYDGAYHTINLRRFDMRRIVKNDPIFEKYRY
The following text describes a protein:
Function:
High affinity carnitine transporter involved in the active cellular uptake of carnitine. Also transports organic cations (By similarity).
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MADPISEPLLSHLTDDSGVNEKTRLEALTFDKIVEQSLSDFGFWQFFQISLVGLALLFDAQQIFITVYTDAYPTWHCLNHTICDPSASDICKLPRSAWEWDGGSQGKSVISEFGLECSSSLLRGMPSSAFYIGAIVGGFFLALIPDDSLGRKKLVLFSTFAMSITSISVIFSTNVWIYTFLKFIIGFSRSQTWSYALVLISERVSTRWRPRATMIPFTLFVLGFMSLSGIAFLAQDSSWRYLYLYTSVPAVFYCIFLYLFALESPRWLHMQGKDKEAIDVLTKMSPKEKAYLESVVSKLPLKQENFEQAPTYSIKDFFFRKWAFRRILVVMIIMFGLGISYYGVPLAARDIDVNIYLSETLNALVELPTFVITPILLERFNRRSSVLVNTLLGGASGVLCFVLSILGKTEIAFAFELGTFFCARIGFNLMAVFMVEMFPTCVRSSATMMFRQALVVGGACCPLIASIGRYIPSVSFAIFGIAMSGLGMFVLILPETKGLSLCDSMEEQEKRDQAVNTSHVC
The following text describes a protein:
Function:
Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome. Note=Also associated with endosomal membranes. Localizes to macropinosomes.
Sequence:
MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS
The following text describes a protein:
Function:
May be involved in the transport of sterols.
Sequence:
MSSPLAAKSNPTTRSISLNTPHSARPNRHHDLRYSLSAGPRTNEDRPQSGNGVAGILYKWINYGQGWKRRWFVLQDGVLSYYRIHGPDKISLSVEMDRRSKLIGGESLRFICRHSKRADVHSPGKPLGQIHLKVSSIGQGISDSKRFTVFTGTKSLHLRAASSEDRTAWIEALRAVKETFPRMSNEELMATTTNVSISTDKLRQRLMKEEVDETIIKDCEDIMKNNFIALHNEVMTLKQYQCHLVDTLKNVNSVPELE
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALAPSKVSSFSGFSPKPSVGDALKNPTCSVSLSFANVKLGSRNLRVCASTVPLSGVIFEPFEEVKKGELAVPTAPQVSLARQNYADECESAINEQINVEYNASYAYHSLFAYFDRDNVALKGFAKFFKESSEEEREHAEKLMKYQNTRGGRVVLHAIKNVPSEFEHVEKGDALYAMELALSLEKLVNEKLLNVHSVADRNNDPQLADFIESEFLSEQVESIKKISEYVAQLRRVGKGHGVWHFDQRLLD
The following text describes a protein:
Function:
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity).
Subcellular Localization:
Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Migration from nuclear matrix in immature macrophages to cell surface in mature ones.
Domain:
The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved. Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity. In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination.
Sequence:
MAVQESAAQLSMALKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSSCSAVDSVVSLLDGVVEKLSVLKRKAMESIQAEDESAKLCKRRIEHLKEHSSDQTAAINMWKKKRMDRMMVEHLLRCGYYNTAVKLARQSEIEDLVNIEMFLTAKEVEESLERQETMTCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQVMGMLAFPSDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTITLQAGLSAIKTPQCYKEDGTSKNPDCPVCSKSLNKLAQPLPLAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFNFSQAEKVYIM
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MSENFKWNLGNNLNSNNNDDFFSTQPFNNNNKFDFSILPDDNNEDEFSGIVNNNNNMNNNNTLVKGDGGIFGNTQINFNNNNNNNNQFGNSLFGNTINNNNNNMEVNNDNDNNNNEQEFEMDNQQLQNNQMEMEEDENQFNNIFNDKSRTDDTIYHNTLEYELQPKLNDDPHLIPIELSDTFLKLSQAKINSINDDESNKLFYMQNNRKQKEQQLKNYQMEKDTWSILKKLYEYRDIQRSIDQKEKIDISQPNQVQVYNYLIKKDHKLRENLILLEWLEEMSSQVELNDNDAVFWEYTLIKLKKSNSITMLTNNQMVSELDPDAMSRQNKPIDKDDEKNQSRFLKTVWSFLRAGDRVGAAEYCTNVGQFWRAQTLIGLNYYQGEHSIGNPYFNLWKSNCLNISKNSNDQYERAIYGLLCGNLEATLPIQKNWYDYFWCYLRVLYDESLYRELKPYRSPLSIEEDIDSPPSTCISQINTPKDILEILKNNTSQIEIKNQSENPYHQIQELIIADDYSILFNSLPNLLLKNKTPEFNRFAVLLILFFRKREQYELISTSEDCPENIVINEYVQHLINSQQYELVALYTSLLNNESLQVDVYSRFLVNIIDPNQRQQLLVLAEKFGLNTQEIAQSVVKTITSGSINTTSNSFENLEFTGFATTINKNKQPKNKSTTTTKASTTETTTNTNTTTTPNLTNTIINQDSSITTQDDLVKINSIQWLCFEKQLLIKAILQSNLLLRDFISLNKYGAASELLKSLPKDIVMIAKQQSPLNESDTNNIIKEFRDWENYITANIRINLWLQNYSNQPKISNYLPQSLNNNNNYINNNNNSFNNIINNSIINSSIAFRLRGNESYAEKLDIERRKKEYDDVYGQWNQNNINFGKEAIVSIRSIIKTGWLCPLENQIGLFSEDDQSGHEVTLIRKKCIPSLFKSLYTILVGIGSIQKSSQLCNQIANERFRWYSIFSKKELQEILQLVRESSIKLLN
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
Subcellular Localization:
Chromosome, telomere. Nucleus.
Sequence:
MTEKQATVYVVDLGKTLGECHNGREETDLEYGMRYVWDKVTLTMSTDHKTDGVGIVGFRTDETNNDLQRSGEQGYENISVLKPLGQFQMTDLEEMQEVIKPNGTEAGDAVSAVVVAVEMIKEHTTLKSGKPGKFARKIVLVTDGKGFMHGEELDDIAKEISRNDIKLVVIGVDFDDAEFGFKEEDKDLVKAENEKLLRSFTESCLDGIFGTIAEAIEALATPVVKVTREYNTYTGPLTLGDPTKYPETAVSIDVARYFKTHQAKPVSARSYVEAGDEELPDADDLTSVKQTRTYKVNDPTAPGGKRDVERDDLEKGYEYGSTIVHISQADEGVTKLQAIKDFSIIGFVPNNYERYLNMGESCITIPQKTNEKARMALSSFVHALNELNSCAVARIVKKDGADPLIVILAPFIEPDLEGLVDVPLPFAEDVRSYRFAPLDKVFNSSGGLMEKHKNLPSKDLKAAMSSFVDSMDLSTAGKDEAGDPVEYMAIEDTYSPVLHRINQAIRRRAVKPDEGVPPPPDVLIKWSHPPSELVEKSSSQLTKLIETADVKKAKAKRNREVVKPLSGLDVEALLGREKRQKITVDNAIPEFKRTLASTDSTESVTKVTREMGDTVRTLLKRSTGNSTWAQAEEYLRVMRTELIDLVEPEVYNNFIEKFKKQLQNEDFDRMFWFDIVRKNKLGLIHTGEASNTEKTEDEARQVCAF
The following text describes a protein:
Function:
RNA-binding protein essential for meiotic progression.
Sequence:
MQRDEERPIDFGMSLELPKTPNDVNYVKKLITQILYLQTLVSEQQKKIESSTLEVQKKKDQIRELERIYEMNPKSFLTLRRTPALKLLPETLSVELSNEVNLTSSTTSSCVKPSPYLTNCNLKNKDTFPVSKNNCSLSSGIFTNSNGTNNCFSTHPKSLDDAKDNVVPKKLNDTDQFPLWSKNETIDPIDLGYSFISPFSMSFASKGNEILDPGESTNKNLFYEFPNGTTEPFEKNSVHSGKETLQYSATISKWKAMIEQIIFQNDQAASLSLQQQLKNEDIEDNINLINTILPFSVTLMKNKFGNFLIQKCFEYSTEAQLQSFSYFLKKHVKELSIDAFGSHVLQKSLEIYPERFTNNLIEELIECLPATLMQRHSCHVWQKFFETRRKSLVDGIFDHFNKKMQGKWLQVSVSEMGSLVVQTIFENCKEKDKRTCLDEIINNMDQIICGQWGNWVIQHIIEHGSEPDKQRILNSLLKEVESYSTNRYASKVVERALRVCHVTFFDRYVKEITTPQNELPTIFLQEIASNQYGNYIVQYLLQVATPSQINLMAEHLKKHMVSLRGHKYGQRIAALVEKSKS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATLTNLEPLATGTVILKTTRGDIQIELWCKEVPKACRNFIQLCLEGYYDGTIVHRVVPEFLIQGGDPTGTGMGGESIYGEPFAVETHPRLRFIRRGLVGMACTENEGNNSQFFITLGPTPEWNGKQTLFGRVVGDTIYNVVRISELELDANQRPVFPPKIISTEVIDNYFTDIKPRSTKEEREKIANELAHQEKQKERNKLLKSGRRNKAVLSFGDEVDMPIVKKPLRQKTPVSRSSDTTTELSKDLISSSSSIHSTYSSAQTGLTSAKVSSDEYARQVDTLDTKLNSSSKSKVQEEISRLKSELRDLEKSGGSSNSKPVVVRPKKRNILTEELEKYKKSKKVVLGKRKNLENDEESTLRALSSFQSKIRNAEDEDVMDSQYGSKIEDTPCSLHNVPGCFSCFDRLGEKNITETNSNWFAHRLVAENDPTRRTEELRIQRAEELKDVPSARPKKLLMKRDII
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGGVKRKIAIEKIQNKNPRAVSFSKRRKGLYSKASELCLLSDAEIAIIATPVSSNSNAAFYSFGHSSVDNVVAAFLANQRPCDERFWWEDESLLKSENLEELREAMDSMSTMLRDLKELEKQRDHQTQTLIHQPCSARVCIQDYVTVNFDGFNTEEQTLAVSDNSNNNGLLGNLDECNEDFDDLDQIFDTVTNSEFLSVNLEMDDVTVNSEGNTEEQTLAVSDNSNNNGLLGNLDECNEDFDDLDQIIEYLTSSEALSMNLKMDDV
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MSTCGNCDCADKSQCVKKGNSYAIETVATEKSYLDAVVDAPAAAETEGDCKCGPSCACVDCQCG
The following text describes a protein:
Function:
Involved in 20S proteasome assembly.
Miscellaneous:
MISCELLANEOUS: Present with 1350 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MLFKQWNDLPEPKHLLDLPEISKNLQSLEVCPVPKVEFPQDLDVPQYSTAVITTKIMNPLFPKNLLQLTSIGEIKTTLTVKSPSLPQSSGKHSWNYDENFPNEVDPDQKNDTADETVYGFSFPIYSFGKTLLFSMEENFISISPIFGNMISRSIISQLAQFSPDIIVIGTSDKIASMKVMTENECTLQPPEFITGFIGSVLTQLIVGPSKGLKFKCLVAPSEGPNGFEKLSLSDMGSLVDLCGQWLGFEPSRYSEECYRLWRCDSAAIGAQSGLYI
The following text describes a protein:
Function:
Catalyzes the second step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L-AltNAc.
Sequence:
MKEFAYSEPCLDKEDKKAVLEVLNSKQLTQGKRSLLFEEALCEFLGVKHALVFNSATSALLTLYRNFSEFSADRNEIITTPISFVATANMLLESGYTPVFAGIKNDGNIDELALEKLINERTKAIVSVDYAGKSVEVESVQKLCKKHSLSFLSDSSHALGSEYQNKKVGGFALASVFSFHAIKPITTAEGGAVVTNDSELHEKMKLFRSHGMLKKDFFEGEVKSIGHNFRLNEIQSALGLSQLKKAPFLMQKREEAALTYDRIFKDNPYFTPLHPLLKDKSSNHLYPILMHQKFFTCKKLILESLHKRGILAQVHYKPIYQYQLYQQLFNTAPLKSAEDFYHAEISLPCHANLNLESVQNIAHSVLKTFESFKIE