lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTSLATQLQRLALPQSELAVPDKDRERASLLFDPKEAANLDRDTFYALGVNGLDELANIDPVFTDFHNNLFSQSSKNLERVVQTKEVNARLDENISRFLTCVSPYFLLRPAQKALEWLINRFHIHRFNTDELVACVLPYHQTKMFVRVVQLLKIDQPTNRWNWMAAIKKPGTPLAWSTVINHCAADLGFLTFICDMVQKAVKVHSSLDSSAPSPMRALISFYATTILGALEVTEIIKENMVTKLLPYIIKGLKSRTIPDYKAASYLIIGQLANKITMQGLLVQTFVKGICKHISPQLSVEAVTCLAVLCHKQRVDKLPKRSFKHLCRVPGLVQTLARLGTAHDITGLLAVFLPALVKAAVNDTVSTTTGTSSEGEDGTTGPVSYCGLLENLLLDVELTESLQTLVAKHLFQEYLTVRGHVAGKSSATVQSLNERVGPIVKLIDRRYPVAMDTILQIHMGQSSEEASHDAEHVQEFVSLSLGGLKHQLVPEAQTSLVLSLNHPNATVRKNAVKHLPKAWESQQGEADMQFVRDGLVQRLRDDDDGVVMAALGIMKDLPTLPKEGLEDTLIPLLRRSGLSEAAAELLTSAALLQDNPAVHDKVAVAVLPLMFVVVPNAKSGEVTTAAMVARSYLCQEHPLLKGAQQGRHNSAPWSHLSQSSDVNVVMATANQGLVSHLAGNLAAMESDTRKSMIQKLYEAATSSTEDCCDLPMVVSFILAHLIGQLDSGDQGALCQQALDLVCNRLHQVGFSEGSKPLQRGKSSLDVQKLKFLHTKVAIMPQNLSIHYQKMSYQGLGPDSPQFVPVLLWLLNNIIVNLHVPADLKSQQWWSQQTADPSQKSYLSLLVQLFDLLVTFTSGNKADHYIPHWRQLMQNFLKVHLPETTTLFRFLSMLWVCHHDNTSHARALVQVRALHMAAVCINSSADKAVSELLSKESGVLPSLLVTLQHRVPTVREAAVAVLGALLEWSGSSMYGEVLVKRLVHAREELVADNNHLKQALQVLFKPLEQAKLPVSKASPGKHKQKAEAKQAVLQTTLDNLLNHVTAEATPCHMKLGLLEALQLVNSQGVLSSLLPMLSTLLEKCPDGLTPEEAVILQHILVRYQVPTAPLLQPSHQALQLFQKSMGISGKPCDGQESPQTMALGQITKEFFSSLPSPAVRQALLCTLFDLQVIAPNPQIAKEISHVLKVISLQAEEVAIELKKFTQSAPSTSVRGAKKIRRATLQAKVTQRSATDSEPWRRVTVILEMLQNKKKVRNLQLIVPPLFAILARCLEEEEQTPVEYLKQLVLTCLLNTCERLSPDNKPLPPAVLPEEQFNAELVVQCIQLSDSPQTHNQALLLLGTAAGLFPDKVLHQAMAIFTFMGAHVLRQDDTYSLQIITRTVDTVIPALIQASERNPSLTVANQKLDSIVAMVIRVFVDALPHIPEHRRQAVFHHLVRTVGGSQYLWTTLALVFESKVVGKTGGGDHSDGEDKVLDTDAEFCVELCSHFPPDVQVLSLVKLLKYVSSLPEDKEDRRGPTPAKRPRRNEPAPSENQSEPLFDVANHTARQLRNFKFLAISFFPVLLGNSSFVGQLVDLEMEGSDKMRGLYQSLLEETLQYIRQVALSLDKNSNNPTARFWRALLHKAYDTLEKVNALLPTEVFIGVVSGLMQNNMATVRKKAMELLNSKLQQPGQQWAQGEVSLLLDMLQELQNVAMATKEDTPTAEELAVNRQTALYSLKLLCRALGTAHPDSFVEVLKGVTKIMGNTEENPLVVSAALLCLAELCTCLKAHAIPHLPAFMPPLINICQSTQLAKSQELLLLSALTAAHKVCESLPHFLSPYLLQLLLQITRLSQLMAEAKEFAQKAHITARLKAIRHCLASTIAPRILLPAIAHCYDELQKHTQGGIGALMSVLSERITTMSKDDIGAHQSQMVTFFMTALNYRAKHAQDDLEVVQQVEGHVMEAVLSLVMKLSEVTFRPMFFKLYDWASRPDSSRERLLTFYRLAEAMADRLKSLFVLFAGHIVKNAAATLDSNNVIKAEESYFGDSDADQRKSSLLLGYIMDCLHKVFLYDNENFVNKETFDLLMQPLVDQIENLQGGEEVFTARVENHVVPCIAQFAVAVGDDASWKPLHYQIMLKTRHDSPKVRFAALQVLEEFQKKLGESFMVLLPETIPFLAELMEDECEEVEDQCQKVISEMETTLGEDLQKYF
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAKGLLAAFPKLLSSGSREHTFIDTESVRYVYQPLESFFVLIITNKTSNIVEDLHTIQVLAKLVPDICAPLSEASIRDKQFELVFGFDELITAGGHSENINVSQIRVNMEMESHEEKLHNMILESKRAAAKDDMKRHTVRIKEEQRERARLERAGMGGSGFGSQNSFSSSFSNAFKSPRSGGSSDSFMSSPSSPAATSPTSYNSRPEPVVSKAAGMKLGSSSSSKGMGLGSGGKSFMDAMAAEDGLKEIPPMSAAVETVQKPEVAAAVSHDPIGAVVEEKMTVLLTRDGALEQLEVKGSMYVSVNDPNAGCCRLKLRTGGVEGISFQTHPKVDKRLYDSESVLALRDSSKPFPTSRVAFLRWSLKTQDESMLPLNITCWPEEEGNGKMNVSVEYSLDRDMVLDNVNVVIPLGGPDAPSVATVDGQYQHNSAEGSLLWHQDQISSANNSGTLEFTVRGSDIDAFFPISVSFFSRSVYSDVQVEAVQKIEDGSPIAFGFEKLLSTDSYQIV
The following text describes a protein:
Function:
May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MKTKNVNLLFALVAVLLFGFSCFCISRMNQTNNQLINCRNHVLEFKETMLRLKNKSENNHQNLVKVLHQLKHKVAPAKPSGSILEKKVNMLDQDETVFNQFEVLKFFLPHLRTAGNIYPDIAIGRQRAGVSFALGITTIDRGNHTYLKQTLTSVLSRMTPEEEEDSVVIVSVADTDENYLKSVVHMVKTRFRKQVQSGALEVISIPALFYPQTLLEKKTTKNAKNWQIKQVLDFCILMLYAQPKATYYLQLEDDIVAKKMYFTKMKDFVNSVTSKDWFYIEFSVLGFIGKLFRSKDLMDFVHFFLIFYRAKPIDVLLDDIALLRMCSFGGPLRSCLQLKREVRVQYKPSLFQHVGTHSSFPGREQHLKDHYY
The following text describes a protein:
Function:
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMSNSSSEIDVIKTRIPTYDEDDNTILYAYETKPEFVNKEPNIVSDASCNTEEQLKTVDDVLIHCQVIYDALQNLDKKIDVIRRKVSKIQRFHARSLWTNHKRYGYKKHSYRLVKKLKLQKMKKNEVYETFSYPESYSPTLPVSRRENNSPSNLPRPSFCMEEYQRAELEEDPILSRTPSPVHPSDFSEHNCQPYYASDGATYGSSSGLCLGNPRADSIHNTYSTDHASAAPPSVTRSPVENDGYIEEGSITKHPSTWSVEAVVLFLKQTDPLALCPLVDLFRSHEIDGKALLLLTSDVLLKHLGVKLGTAVKLCYYIDRLKQGKCFEN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MQDRGKEAVRLCEQIVAHAFGDIVSRVASTLLNRGRLPAPTIARLSGLTPPVALSALLILMQHNLVQSNGASAKETGEDEQYEFIVEECLLRLRWGRMLAITHERVDFLAMQVVKQLMIFGKLRVPDIISGLGGDADAIRAEAITGSIIALLQNHFLQTTAPELQILESDQIARRFAANKRRLAQAQGSALLSANDITNCRLEAAHDVRTANESLRAITRVLITKPKVDKNTKRRKGGKAIEESDYVLKQDVHLRVNYDRYGVLMRNDLIVKAAEDRWNKGAGIVMRAVLDASLRDTSLLKDDRTHDPVGINSIISLIPPSSAPILLAGLGLSSKSSIPDLVRTYLSILAGEDQLTGTGAGVFLQREGSTNPGYKVEFEAICVKMREAMLSDLVREKLGDKAARVLAVVTRSSKAFETTIRDCAMLPLKDARYILAELQKLSLVETQEVPKTAAKSRANMPSSSSAEYHLWAVDLSRCYSVLLSSVYKTMGNILQRRRAEMDKKKVVLAREQRVLGLGHGQEGGRGLLQLKDQEDLAELDDTRNKLALAEMRSEMVVFVLRDLPGLPGQNAM
The following text describes a protein:
Function:
Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus.
Sequence:
MTAEFDEEVVFENSPLFQYLQDLGHTDFEICPLSKEEERLAENGQGKQDVHTTEKKSIISRTVEFLKSWSPFLSKKKKDEKIHLLEIGFRLESLRTILQQEVLIQEDVELIELLDPGILSAGQTQNQQNDHLPTLWSIATPNIWETSILFVFLSAVAAFQSWSISSSLIWGPSLILFAAFTVLKTLHTWRSARLRIILRKYCTQVEGTVSNSRAFTNLVRKALRLIQETEVISRGFTLVSAACPYGKAGQHASQHLLGLRKAVYRTVRTNFRISRLATLYMLKHYPLNSEIDNVTNYICVVPLKDLGLGLCEEHVSEEDAHNLTDAFSLPALKVLFQLWIGQSSEFFRRLALLLSPENASQGPSTSPEQLPHFIWSDVVQDLPHTQAACMAELKRSYEFYRYFETQHQSGLERTAKRKEVGELNNLHGAVRSLQLHLKALLNEVIVLEDELDKLSSCKEMQAVTPEASLMLEEKLRIIQPHVQASNTCWEEALCQVERMVRKPTTKKDTGKYSCENLNYPVVSNVPPAMRIEDRDPVPEEQILEAYVEEAVTDQEFNSEEIYLFSPEERERQKREREESRRVLQELKAVLGLKASEAERQKWKQLLFSEHAVITPLLPEEPVGHFEPLLSIYPEEPHKNLGFYGEIPSEINGTEHVKDAPIQVDHGNMNHEDEAKICPVSEEVEPASCKEEEDETPCPAPRTVLPPAIKERLARIHQSSDLNFTSGLATQVAARSLTFTFLQEQTFGDEWDDDDDNEDHDHDKERNNDSSQLEG
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence:
MTLKARLRTSIGQQLVMTPQLHQSIRLLQMSNAELQLEITAAIESNPLLDWAENQSSETSEATEREVETEDWQAKESAWDINGSKSNENDDNNPAERLTTGNTLTDHLLWQLHLSPLSARDYQIGTVLIDAIEEDGYLRELLSTLTATLAPLSVDESELLPVLRHIQSFDPTGVAARSLAECLTLQLKSLKEEIPGRALALQIVNSPLLEQLPRSGVTGLARELKRPSQDVQQAVELIRGLDPRPGKKIGDLEVGTYVVPDCVIWRQHGLWQAALLERAFPQVVLHRGYEQLINRCNDANASYLRNQLQEARWLLKGLEARGETLLKVVNSLIRHQTGFLEFGQHALRPLTIRELATELALHESTVSRAIAGKYVRTPRGTLPLRTFFASGISTDSGGETSNSAIQAIIRRLIETENPRKPLSDAKLAELLKTSGIPVARRTIAKYRDAMNISASHERVRVL
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MDRLLQLEVFAKTAELGSLSKAAEALRMSNAAASRHLSALEERLAVRLIERNTRRLWLTEAGQELLERSSRVLSELAEAEDIVSDRALSPQGMLRVTSSLSFAVIYLAPMLPAFRARYPKLNMQITTANRYPDFIEAGIDVAIRTREQEPDSNIIVRRIGQMRRVLAAAPSYLASAGELEQPADLARHNMLVYNLANDPYSLRLRKGNGAQTVRITPTLDSNDGQVIRGAALAGLGILIQPLYIVQSDIAAGRLVPVLLDWELPLLTMNIAYQNRAGLPAKIRAFSDFLVTHIREHSQPGIWMDAAK
The following text describes a protein:
Function:
Negative regulatory component of the MBF transcription factor complex involved in cell-cycle G1/S phase-specific gene expression and more particularly DNA replication checkpoint-dependent gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MSLSDSPSKSGNTGKDLISNNEAKNHEDEETHQKKRRRRTTDAEATLLEQYFLKTPKPSLIERQELSKKLKSSMTPRELQIWFQNKRQSLRRSNCLSRNRLEGTGENSLLRRKSTLTLCETSTGQAELFFQSWPLHSQSVVGEMIHHEQDDYNKENKQQKVVDTTKDISRGSNGNEDSAAHQELEECARSLVELQQQCNDH
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASTSAPLPSAPAPTSSATHLGLLPEIPRASSIIVIGMAGSGKSTFTASLHDHLHEREKEQQDEREQQQQTGASASEPASTSQITAPYMVNLDPAVGTLGYEPNVDIRDTVDYARVMEQYNLGPNGGILTALNLFTTKFDQVLNILEKRAKQVDHIVLDTPGQIEIFTWSASGSIVTDALASSMPTVVAYIIDTPRTTAPATFMSNMLYACSILYKTKLPFILVFNKTDAQSHQFALEWMQDFEKFQQALAAGNATDPSSTVTQQGLDPRARNYDAEGSQGYMNSLMNSMSLVLDEFYKNLRAVGVSSVTGDGMDDFLAAVQEARQEYLNDYRPELERLAKQRDAKRETSKKEQLARLIKDMNMGGKSTSVQDSNVAKVVTKSSEDLSRHIDEEYEGDGQIIEPDSDEEKPHYEYPGPEYDRGDGTVWPRPG
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. Binds an atypical recombination dif site (difSL). Binds preferentially to the left arm and cooperatively to the right arm of difSL.
Miscellaneous:
MISCELLANEOUS: In contrast to the XerC-XerD complex present in non-streptococcaceae bacteria, XerS acts as a single recombinase required to recombine difSL recombination site.
Subcellular Localization:
Cytoplasm.
Sequence:
MKREQLIQNIEKLKHVMPPYVLEYYQSKLTIPYSLNTLYEYLKEYERFFSWLVDSGVADVDKITDVSLSVLENLTKRDLESFILYLRERPRLNTHSTRYGVSQTTINRTLSALSSLYKYLTEEVENEDGEPYFYRNVMKKVQTKKKSETLASRAENIKGKLFLGDETQGFLDYIDSEYEKTLSNRARSSFFKNKERDLAIIALILASGIRLSEAVNVDLRDLNLNTMIVEVTRKGGKRDAVPFAPFAKTYFERYLEVRSQRYKTTAKDTAFFVTLYRDIASRIDPSSVEKLVAKYSQAFKVRVTPHKLRHTLATRLYAQTNSQVLVSNQLGHASTQVTDLYTHIINEEQKNALDSL
The following text describes a protein:
Function:
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.
Subcellular Localization:
Secreted.
Sequence:
PGLSICLSLLTLSVSLGFLCSRLETSCIKDCLQEQLRLRAQVRMLERQVKRQHVAMEQLRREKEIQLLEAPGEGMEAVGLGGLRTYADCSEIYNDGHASSGLYQIQPLRSPERLSVHCDMSDGGGWTVVQRRSDGSVDFNRGWDDYEKGFGNFELKNGEFWIGNKNLHLLTSQGNYTLRIDLADFEGESRFAQYESFKVGDEKSAYVLSCGRYSGTAGDSLGLGSDPEAEWWGSHRKMKFSTWDRDNDNYEGNCAAEDKAGWWFNRCHSANLNGIYYRGPYTALTDNGVVWHSWHGWWYSLKSVRMKIRPGDFVPNVV
The following text describes a protein:
Function:
Transcriptional activator that acts as a floral inducer to promote short-day (SD) flowering pathway. Activates HD3A and other FT-like genes independently from HD1. May also activate MADS-box transcription factors involved in flowering regulation. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. May directly activate some type-A response regulators in response to cytokinins (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDHRELWPYGLRVLVIDDDCSYLSVMEDLLLKCSYKVTTYKNVREAVPFILDNPQIVDLVISDAFFPTEDGLLILQEVTSKFGIPTVIMASSGDTNTVMKYVANGAFDFLLKPVRIEELSNIWQHIFRKQMQDHKNNNMVGNLEKPGHPPSILAMARATPATTRSTATEASLAPLENEVRDDMVNYNGEITDIRDLGKSRLTWTTQLHRQFIAAVNHLGEDKAVPKKILGIMKVKHLTREQVASHLQKYRMQLKKSIPTTSKHGATLSSTALDKTQDHPSRSQYFNQDGCKEIMDYSLPRDDLSSGSECMLEELNDYSSEGFQDFRWDSDKQEYGPCFWNF
The following text describes a protein:
Function:
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Subcellular Localization:
Cytoplasm.
Domain:
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Sequence:
MTKRTFAPVPTQPNFRQLEADILQKWKDEQVFEQTQTRPAPAGEFVFYEGPPTANGKPALHHVLARSFKDLFPRFKVMQGHHVTRKGGWDTHGLPVEISVEKKLGWLGRNHGASREELEEFNRLCRTSVWETIQDWNELTERMGYWLDLGDPYITYQNSYVESVWNLLRRLHEKGLVAQDYKVVPLSPRISSTLSRAELGEVDSYRMVDDPSVYVRLPIVWDTLPERAHAALSSLSGEQRQGLSLLVWTTTPWTLPSNTLAAVNPDLDYVVADSPSGRVIVAEGAVERLSALHKDAAPLEVLARFKGRDLEWVEYEPPFPEVASQLGVVSELHERRDGKPVLHFVVMADFVSDVDGSGVAHEAPAYGAEDLEVARAYGVPLMFGVDDHGILQVTHEQGKFFKDADKGLIADMKARGLMFWAGTLKHRYPFHDRTGDPILYFAKKGWYIRTSQVAGEMLAQNEKINWVPGNIKHGRFGNWLEGNVDWAISRERYWGTPLPFWQSESGQLRVIGSVAELSELAGRDLSDLDLHRPYIDDITFTLDGEEYRRVPEVLDVWFDSGSMPYAQWGLLLNEQGEAVRGAEQFAKHYPADYICEAIDQTRGWFYSLHAISTMLYDQPAYKNVICLGHIVDEKGLKMSKSKGNVVAPLPLFDQYGADSVRWYMFMASDPGDQKRFSERLVAEAQRSYVNTLWNVYSFFVLYANLDQPDLAAAPAVAERPEMDRWLLARLEETVRDVTAALESYDARSGGRALEGFVDDLSNWYVRRSRSRFWGEGGTVDTAAYATLHEALLVVSQLTAPFTPFLADALYRNLSGEESSVHLTPWPTVRAERLDRKLTADMAAVMKVVELGRAVRGAHNLKTRQPLAGVQVRAASPEALDALKRSQTQIMEELNVKAVTFLEGDTDLVQYSLRPNLPVVGKQYGKQLPVLKKALTEADARAVATAVQAGQGFSVQADGVTFDLTPGSVLVDAKAPEGVAAAEDAGYLVAFDTALTPELVREGLARDLVRAIQEARKAAGFEVQDRIALALELDGEALEAAQAWQDFIAGEVLAEQVAYGSGEGFRAEVEGGAVTLKKL
The following text describes a protein:
Function:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWAFPELPMPLLVNLIGSLMGFVATVTLIPAFRGHFIAARLCGQDLNKSSREQIPESQGVISGAVFLIILFCFIPFPFLNCFVEQQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPLRPILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELDGDYRDDHIFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRMPRLNTKTGKLEMSYSKFKTKSLSFLGTFILKVAENLGLLTVRHSEDEDGAFTECNNMTLINLLLKVFGPMHERNLTLLLLLLQVVGSAVTFSIRYQLVRLFYDV
The following text describes a protein:
Function:
Nonribosomal peptide synthase-like protein; part of the gene cluster that mediates the biosynthesis of cichorine, a phytotoxin active against knapweed, corn, and soybeans. The first step in the pathway is performed by the non-reducing polyketide synthase pkbA that condenses one acetyl-CoA starter unit with 3 malonyl-CoA units. PkbA also catalyzes one methylation step to produce 3-methylorsellinate. The nonribosomal peptide synthase-like protein cicB, the cytochrome P450 monooxygenase cicH and the O-methyltransferase cicE are involved in the conversion of 3-methylorsellinate into nidulol. CicB converts 3-methylorsellinate to a yet unidentified intermediate, cicH may play a ring-closing role for cichorine and cicE is plausibly responsible for the methylation of one of the phenol groups (Probable). The oxidoreductase cicC acts downstream with still unidentified enzymes to further convert nidulol into cichorine.
Domain:
Contains three distinct domains: an adenylation (A) domain that activates the substrate amino acid which is subsequently covalently linked as a thioester (aminoacyl-S-PCP) to the 4'-phosphopantetheine prosthetic group of the second domain, the peptidyl carrier protein (PCP) domain, as well as a reductase (R) release domain.
Sequence:
MARNQQLRPFKRPAIRLYPAVNETELIRTLPEVVEFNAQANPDHVFCLQAKKSPNKSILSLVSVTNRQLKQAISQCVGWLKSNLKLQLPSLLHGSVEKGAPVALLMESDIGLFIYEIALIGLGVPVLLLSARLSAPAINSLLQRTSAAAIIVSGRLEATAREAAETLPAAVFSPLPFEAFLSTNEGLPDNDSICHPYHYIDESDRNVLILHSSGTTGLPKPIYVSHRHLLSFVNCHRLDLESEAQGVNVSTLPLYHGFGLVAPALAMGVGKTVCFPPGSTVPSAGATLDLLRISNAASFMTVPSILEDIAFLGDEGIQALAGLDYVTFGGGILKPSVGEELAVHGVKLLNHYGTTESGPLAPIFVPQDDYNWRFFRLRDDLRLQLDEIAPNGNERRFKLTTFPFGLEQPFEIQDQLVCNPDYPGSDFNAVGRNDDTIVLATGEKVQPQILESILCESSLVKSAIAFGEHQFEIGVLVQLAADVPPKNYSKLREQLWPLVARANESMDGHARIQSSEAVLLLPSTVTIPRTDKGSIARKDVYKMFEADIAGVYRKLESAGPVLCLDMETLEEDLKLLISRCTDWPPDWAVTDDLFERGMNSLQAIRVQRALVAAVTRSLRGVCQPERIGRDFVYIHPSVRAMADFFREPVNGLQLPNGFSTRGWAPDQLVQRFALTSKDGRATVLLTGATGSLGSHCLLSLIQSPNIKRVICLVRPEDSFTDPRLRLQKSLESKKLHLSSTQWSMVDVLGCHTASQYLGLTREQYTILQESVTYILHAAWPMDFHWKLPSFQSQFQSLHNLLALARDIHNRRPSIKPRLTFISSIATVGQYARVHGVRMVPETSVDSVECLNPIGYAEAKLVCERMLEHARLHYPHEMTVSYVRMGQIAGSSTTGFWNINEHIPALTLSWIPVDVAAQSITELLLSPAPAELIYHIENPIRQSWHDMLQTIAAVLHLSASDALPWNEWQEQVAAAGDTDNPAKKLQDFFANDFIRMGCGEVVLGTDKARKASATLRRVDAVSEGCVRGYLQYWKEIGWLK
The following text describes a protein:
Function:
In the first mitotic division in embryos, required for mitotic spindle alignment and asymmetric cell division. Required for motor-driven chromosome movement and homolog searching within the nucleus, and subsequently ensures homologous chromosome pairing during the prophase stage of meiosis.
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane; Multi-pass membrane protein. Note=Localizes to mitochondria throughout interphase and mitosis. Localizes to mitochondria in the pachytene and transition zone regions of the germ cells.
Sequence:
MDQMTVEEKILEHQELEDGSSSFRWLVSSTVIAIGGATVALYISGKIDWKIPAIEAGLALTAGGTITCGYLWFKKRVKTVRKLILQMNKTRSALRKRRQIFFSISMCMPRHRHPSILRACRLTVSAIECLTEETKSLNNGTTWQDLYTDEIREIISRSTVDSQLLKIEEIQEGDNDKMDFEQVFETLISIFKLHASEYSRVVILNFLNSPVFESKKVSKFFETLGRLQELMYNLESVERLALKTETKLSRNERKMDGKMKNKSLLELGWKQQTALALEAILERLESESVTQSEVESALHKTFLVVKAEPAFPQPVKKIDVEVKNQDQKNPEVIVIEKGTGERTDIDMVFEGTPLSEADKLSASKSAVARDVLLDGSEGRCHEASLFGELKMVLEPRRTDFAKRERTALAKFYGVDEHQLEQKEDEETFEAIASGDGEDPDPYDWRKDAEMSAGIHHDANNDDFLKSLKLRRVDDDIIE
The following text describes a protein:
Function:
Involved in lipid remodeling during GPI-anchor maturation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAGLWRELLLESLLGYVSWSLCHGLGPMIYYFPLQTLELTGLEGFGIAFLSPIFLILTPFWKLANKRWMLILLRLITVGSVASFQASNARVRLVVLALGVSSSLIVQAVTWWTGSGLQRFLRIWGFILGQILLLVLRIWYTSLNPIWSYQMSNRVILTLSTVATLDRICTDGDGNKPEGKRPGEAAKGTASRPAWWLAGAAFGSLVFLTHWIFGEVSLVSRWAVSGHPHPGPDPNPFGGAVLLGLASGLMLSTCPWFPGSGLIWWVTGAASAAGLLYLPTWAAAVSGCVLALFTASMWPQVLAHLISSGSGPGKAMTIAMIFYLLEIFFCAWCTAFKFVPGGVYARERSDVLLGAVMLIIGLNMLFSPKKSLDFLQTKNSPKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYENKLGKGAPATEVSAAIWPFRFGYDNEGWSSLERSAQLLNQTGADFITILESDASKPYIGNNDLTMWLGEKLGFYTDFGPSTRDHTWGIMVLSRYPIVKSEHHLLPSPEGEIAPAITLTVSIADKLLDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYVQLTEHGDVKDIDSTDQDRWCEYIMYRGLIRLGYARISHAGLSDSEIQMAKFRIPDDPINYRDNQKVVTDQRKVPKEIRFNPRFGSYKEGHHYENNHHFHMSTPKYFL
The following text describes a protein:
Function:
RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure (By similarity).
Subcellular Localization:
Nucleus speckle.
Sequence:
MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKTNKGDALANRVQNTLGNYDEMKDLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEAEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRESQHLTPGFTLQKWNDPTTRASTKMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSIDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEMLSPLRDHENLKNLWVKIDLDLLSRVPGHNSLHAAPAKPDHKETATKPKRQTALTAVEKPAPKGKRKHKPTEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVGNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MAQNVSSNRSSGKTTPLKQMEITHNRGGLTPSQREHYRQQVFGKICEGMRLCLELMNKEDIELENADLMKFVPMFNHCVNLEPRQPFPHEYLEPLSLLCGDGGIKKALDSGNNSVLLENMKYFFPELDRLFQPSYVPTDLDILHCEGKTCQGKATGKTETTMIDQSKLRMIDRSQQNLSDLLLMDQAIEMANEALVANEIPVGCVLVSKTTDKVLSKGRNRTNETKNACLHAEFDAIGGLHSVTPADKIDWNDVKLYVTVEPCLMCSSALRQIGINLVYFGCSNDRFGGCGGVVSIHNDPRLIHSQPLTALGGYRREDAIILLRKFYITENTNAPVPKKKTNRVLKMEIPDL
The following text describes a protein:
Function:
May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.
Subcellular Localization:
Secreted.
Sequence:
MKGSIFTLFLFSVLFAISEVRSKESVRLCGLEYIRTVIYICASSRWRRHLEGIPQAQQAETGNSFQLPNKREFSEENPAQNLPKVDASGEDRLWGGQMPTEELWKSKKHSVMSRQDLQTLCCTDGCSMTDLSALC
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm.
Sequence:
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPASKRESKSRSRSKSPPKSPEEEGAVSS