lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in coelomocyte endocytosis.
Sequence:
MAAIINQRVEQGESSMGGAKPALLHRITGHVARINDVILLSKDEGVWTASDDRSVRLYLKRDNDQFWPSIHHFMPVAPTSLYYSEETYKLLVGLINGNVYEFSVADDFNSMTESRKWTCHAGPISGLGFALSSELIFSCSRDKSIVWHCSENSNKMGSYLLENSCTAMVIDLPFVFVGDHGGHVTVLRIVDNQPNLVSKLSAHTNAITSLTWDGNKKVLYSGSSDHLIIMWDIGGGRGEAYELNGHNGKVTTLCAAPAAKRLFSADEHGKLMCWDMNCKRVETPEWKTSDCCQKCNQPFFWNLQAMWQRKVVGLRQHHCRTCGSAVCGSCCDNWTTYPPMGYETKIRICNDCNARMKDNPQNFNLTPLAIPHEIHTGITAMHLQETLGLLVTSGQNRVIMIWDVRSVCSAPSGSQ
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MKSKSYNNNKFSSPITWVGKQYQPDVNCVKNRFAAFYSKCIFGALTLEVGNYVLVSDMDAAEPDSIDGCDVARIVHMYEVLNSDCTNMDPCRAIVEWYSRPSALPKLITGDENYTFDAREVIADSRFSPDISIETIFNLCWVEHVPLQTNLAEIQALKSSSRGPSFFARYKLEKASGRKWSLNALVPMVDATTPRKRRSMYDRSNEPIIETPKTPKLKLTRTKSLENMASLSPNQKSKLIEDRWAVKLIDVKQNIDEITDILSEIEISDSENRRPTANQEKLQKVRRSSMNLRLHPKPSAYASNSGTDDECLNYSIVRDGATTSERQIKIKLRLSENQKNTESPKSLRKRVTSSSVPPEHVSPPKCRKSLLPADVESVSTPSGRSHRKSILKTPSTHASQVGTPKRNIQLSNIIEECSNGRRVSRLLELSPKKLEPLPIEEPKTPKRNSRLSSVGATLPSSASKGTPKSANKMKLIRDGTIKPNIHSRDAPVQDGANELAVARERLHVSATPSSLPCREKEYEEIYNFLEGKIFDGCGGCMYISGVPGTGKTATTTAVLRALKHLSEEEDIPKFEFVDINGMRLTEPRQAYVHIYRQLTGKTLAWEQAYNLLNKRFTTKAPRRITTVLLVDELDILCNKRQDVVYNLLNWPTMPTAQLIVVTIANTMDLPERLLMGKISSRLGLTRLTFQPYNFRQLQEIVMARLVGMSAFNSDAVQLVARKVAAVSGDARRALDICRRATELADDQARKSNESVTVSMMHVQQALTEMITSAKVKTIRSCSRLEQLFLQAVTAEVTRTGIEECNFLGVYSQFESLAAFSGIIVPNPGRAMAICARLAASRLLICECGKSDIYQKILLNISTDDVHFALQASKLL
The following text describes a protein:
Function:
Non-catalytic caspase homolog which does not contain the region necessary for caspase activity. Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4-induced ced-3 processing. Has no effect on active ced-3. Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development.
Subcellular Localization:
Cytoplasm.
Sequence:
MFFGKLGGFAFFLQRAVRCDGFIDNFFDRIPKFFQFMKSKFPSHQTSSSQADLLVSFSTSPGFLSFKDETKDTWYIQELYRVIIENAKDTHLADLLTETNRRVVEKYEADKVVFVCKQAPEFWSRFTKQLFFMSRNDVF
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MATRTQARGAVVELLYAFESGNEEIKKIASSMLEEKKIKNNQLAFALSLFNGVLEKINEIDALIEPHLKDWDFKRLGSMEKAILRLGAYEIGFTPTQNPIIINECIELGKLYAEPNTPKFLNAILDSLSKKLTQKPLN
The following text describes a protein:
Function:
Does not function as an antitoxin to the upstream RatA toxin.
Sequence:
MPGKIAVEVAYALPEKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSRPAKLSDSVHDGDRVEIYRPLIADPKELRRQRAEKSANK
The following text describes a protein:
Function:
May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
Miscellaneous:
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MLQFNTENDTVAPVFPMEQDINAAPDAVPLVQTTTLQVFVKLAEPIVFLKGFETNGLSEIAPSILRGSLIVRVLKPNKLKSISITFKGISRTEWPEGIPPKREEFSDVETVVNHTWPFYQADDGMNSFTLEHHSSNNSSNRPSMSDEDYLLEKSGASVYIPPTAEPPKDNSNLSLDAYERNSLSSDNLSNKPVSSDVSHDDSKLLAIQKTPLPSSSRRGSVPANFHGNSLSPHTFISDLFTKTFSNSGATPSPEQEDNYLTPSKDSKEVFIFRPGDYIYTFEQPISQSYPESIKANFGSVEYKLSIDIERFGAFKSTIHTQLPIKVVRLPSDGSVEETEAIAISKDWKDLLHYDVVIFSKEIVLNAFLPIDFHFAPLDKVTLHRIRIYLTESMEYTCNSNGNHEKARRLEPTKKFLLAEHNGPKLPHIPAGSNPLKAKNRGNILLDEKSGDLVNKDFQFEVFVPSKFTNSIRLHPDTNYDKIKAHHWIKICLRLSKKYGDNRKHFEISIDSPIHILNQLCSHANTLLPSYESHFQYCDEDGNFAPAADQQNYASHHDSNIFFPKEVLSSPVLSPNVQKMNIRIPSDLPVVRNRAESVKKSKSDNTSKKNDQSSNVFASKQLVANIYKPNQIPRELTSPQALPLSPITSPILNYQPLSNSPPPDFDFDLAKRGAADSHAIPVDPPSYFDVLKADGIELPYYDTSSSKIPELKLNKSRETLASIEEDSFNGWSQIDDLSDEDDNDGDIASGFNFKLSTSAPSENVNSHTPILQSLNMSLDGRKKNRASLHATSVLPSTIRQNNQHFNDINQMLGSSDEDAFPKSQSLNFNKKLPILKINDNVIQSNSNSNNRVDNPEDTVDSSVDITAFYDPRMSSDSKFDWEVSKNHVDPAAYSVNVASENRVLDDFKKAFREKRK
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTSVKPIKEKPAGKSLFSTSAGGASLLIALQTGSRALTFIVNQILLRYLSPELLAVSTQLEVYSITVLFFSRESLRVAIQRQTDVNDDDSKAKQDRNLSRKDIYLDSRTTAGKSQAIVNLSYISIVLGLVSTMIFGWIYANARQTGVVETPYFGQSLRLYGVAAILELLAEPCFVVVQQKSAFKIRATAESIATVLRCIVTCAVAVWAAHHQKELGVVPFAIGQGVYAISILLAYFLAVWHIASRGGFSLRLKPISSKKNEYIYSYFSKPLLSLGGSLMIQSMVKHVLTQGDTFLIASMATQKSQGIYALASNYGGLVARLVLQPIEEMSRNYFGKLLSAVDGKTTKGATKKASADLQRLLRIYLILSVAIVAVGPVVAPLLLNLIAGPRWQSSGAGNVLAVYCYYIPLLALNGVCEAFVAVVATEAEVYRQSLWMTAFSAGFGSAAYLFLGLLGLGAEGLVLANMANMLLRITWCGHFILAYCGSHGAEFKVMDLLPRPSTISLGVVTGYNQMWLSGNDFCDSPSHE
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MVQCESDCREKMEGTGAGTATGCYKCGKPGHWSRDCPFSAPNPNPNSNTATTPNPNTPNPSSSSFKSRSATEKPKKLPRTKPKLTPELLLSDDGLGYVLRYFPREFKYRGRGHEVRDLGNLLRLYTEWHSRLLPYYSFNQFVHKVEKVAATRRVKTCLRELRERVASGGDPTKLREPPVVHDIPSDEHGFSVSAEDGGATHQEADLFAEFENVNDIQEDMLNDIYDKATEEPSQSMHNVIGTSMASESNATEKTSEENGSSQSGKAEITEEQRARMEANRLKALERRAEITEEQRARMEANRLKALERRAALSQASQL
The following text describes a protein:
Function:
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQGNILKKFIEELRSGEQTGEDNFSSDFMRLRRLSTKYRTEKIYPTDVGEQEENVKKNRYKDILPFDHSRVKVTLKTSNQDTDYINANFIKGIDGPQAYIATQGPLPNTVLDFWRMIWEYKVAVIVMACREFEMGRKKCERYFPLFGDEPMTFGPFRISCESEQPRTDYCVRTLTVEFDQECRRLTQFHYVNWPDHDVPSSFDSILDMIELMRKHQQRDTTPICVHCSAGCGRTGAICAIDYTWNLLKAGRISEDFNVFQLIQEMRTQRHSAVQTKEQYELVHRAIAQIFQKQLKLLESPTNSEVTDGTLQEDSSPEKHTPNSDEEQWDTPPPKPPRLRSVQGECAVQEEILQAPEPRPVPPILRPSPASALRTVSSARHSDTYHPKPLLSDPEPSDPEPSTHFTDPDHHSSDPEPSEPERRVERLAVEIQKVALQEGPRPLHLLLQSPAHAPALSFTNPLHTHTHSHTLPDTHPTAAGGTAEQQNQRRATHMSIAGHTLHTESSEEQPAGAADTAPLQASGDTTAAPRENDAEQKSTETPVSGTKAEIGFGRRCSPPRGPREPPSEWT
The following text describes a protein:
Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MHPSWGGFGGGHQPPPHFGPRPHQFRAAQPPPPTTAPPPQPAGAPPPGGGGFAGYGAPSFPPSNFSSLHEQHLQQMQQLQQLHQKQLQSVLHHSGNNSNSPSPYWQAGGAGPAAPPNSFQAAGPQPQPPPPEVKPPAPEPPPPAPAASKPPAASTPQVSDASAPVGDEKPDFSKMSMQEQQEYWYQQHLQNLQKLKNEKAKQNQGSFNESHASAPPPPVEPPKSTPPPPPPKEEPPPPPPPDESQSSSVNNTGDPAEAARLQQLQVAAAQWQQVQHQRASFQYQALMQEHAQLQQILQQYQQVIQQPAHLQTMPFEMQLQHYEMQQQRFAPLYQEWERHFNLWLEQFQMYPHKDQLHDYEAQWRQWQEQMNSTSAHLQERVTTLRAMQHQYGSSYGMMGSYGQQSPNVQMGPNGNMNLVGPGTPSMPPPVTMDAMPAPSTQGPSQSGPVVPQGHSPSDLESISETCKTGLPPGHGVRPPGPGVRPPGPGVRPPGPGVRPPGPGVRPPGPGVRPPGPGVGPPGPGAGPGVGQPRPGVRPPGPGVGPPGPQGVRPYGPGGRPPGPGVRPSGPGSGPPGPHGRFDGPRFEGPRGPQFEQPPQQRFSGPPRFDAGQRFSQPPRGNPPFPGAPARLENPPRQNTPTRFERPPVASQQTGSGQQSSPVTGNQTKQQSAKPEAKPVPPSYTDPDKAKSPLSQSTQKENNSSAPSMTDDLVDSVDGFFIQSGPIPQTKDSDKTDADSAKQDKTKEVTTKPSAPTDAPDTTNKNSNLQPPKTSHTANGPPQQVKPPQNKFKPDTPKETPRMLPMMNQQVPPQMARGRGRGQIPMPLRGRGRARGRGQYGGPMADPNFQREIEEDSYDHQEPGNASHGEDQDRIWRDPSLDGPEEIDQEAPLEIWQPEEEHFPEEYPEDTHQDENWEEEPQDYWEEEDPYWAEQRPAMRARPPFPPGGPRRPPFHPRFMLQGPRRPPPPGSLQHNPLGPPPFRPRGGVVPRFRRGLGPWGPLPRHDMMERDLRRPPAPHEIIAREPAGPHGYEEEIDREPAWPHPRGRGIRRPPLPPHEMGRGIRRPPMRPAMPRERWHGPPPHEEENYEEEYPYGAEDDVYRRPPHEYNEDYEHGDEYYGSREEWDGEQPERDYPPHRPPERVREDPWLEERERSFPYEEDRYREERRGPFYPDDPPYQDRDREPPFHSRSDWERPPPPPPPERGYSRSLSETDYEHKLDPLASLPAPQATDSPLDESSPSATKAVLALSQRQHEIILKAAQELKMIRELQETKKALGEVSTTESAGLPSELPAGILGLEIPPEVKSALQATNLLSETGQTFNAGLSSNQSTDFLSSTAPTASFIAKTVDYAHGRDGGSTVERISYGERVLLRPAPAPSERSYEKELLGHRDPYYDRRSDPYAARDYDREWERDPYREKPTLDYERDRYERDRYLRDERASLGPRPTYREREREHSSRSSRDRELYNRPSYERSSYERSLEHYEHGSSSYGERRSYPDERQPPPTSLPPSAPVAPPVEKKPEIKNAEDILKPPGRSSRPDRIVVIMRGLPGSGKSHVAKLIRDKEVECGGAPPRVLGLDDYFMTEVEKIEKDPDSGKRIKTKVLEYEYEPEMEDTYRSSMLKTFKKTLDDGFFPFIILDAINDKVKYFDQFWSAAKTKGFEVYLAEITTDQQTCAKRNIHGRTLKDISKLSGGWESAPPHMVRLDIRSLLQDAAIEDVEMEDFNPSDEPKAEVKNDDDETDLGYVPKSKWEMDTSEAKLDKLDGLVGGGKRKRDAGLSGMEDFLQLPDDYATRMSEPGKKRVRWADLEEQKDVDRKRAIGFVVGQTDWEKITDESGQIAQRALNRTKYF
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MPAELPPSAPQFFKDLAELCPSETLRRQLLELQRTRNWNDMTAVQRAAIPLALEHRDILCIAPTATGKTFGYLFPSMLRLAMYAGTDGSSNLTGSVSEDLNRPNIEKLMQDKMEKGEVCRYCELSVTEVRVCPLTGQPHPDPVPEDAAKQQRSPMWVSELSSVAEPLLLVLVPTSQLVMQVYHLCKKLDADFRVKFLVRASSAEEQKRHLNALEGCDVLITTPETMLPALYKRKLSLKRVKVLVLDEVDDLLSTNHFEKVKIILGALPKGPQRPQRLLFGASLPPSVYQMIKEQMLLPSHRFVLVDVKTDKLGHPIAPAPGSICGAAVCASITHVVFMVSQAEKISRLAWLYSSGKLRKDQRTLIFCNSRHNVAYVCERLQNLVPGLRVTTLTSHSSATGKTGTMKLFSRGASTCLICTDILSRGIDFADVIYVVHYDVPTEFETWVHRSGRCGRRGLRGYCYTFFQPENVRLAKPLVAHLRQTQQLIPPKLQEYARQSLIDVFKTSLFYHPTRRYRPRDPQQQAPVLGRATPRFPDYKQDRLNKNFRPL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes. Involved in nutritional control of the cell cycle. Targets the G1 cyclin PCL1 for destruction. Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck.
Miscellaneous:
MISCELLANEOUS: Present with 2790 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTNTVPSSPPNQTPPAASGIATSHDHTKFNNPIRLPISISLTINDTPNNNSNNNSVSNGLGILPSRTATSLVVANNGSANGNVGATAAAAATVETNTAPAVNTTKSIRHFIYPPNQVNQTEFSLDIHLPPNTSLPERIDQSTLKRRMDKHGLFSIRLTPFIDTSSTSVANQGLFFDPIIRTAGAGSQIIIGRYTERVREAISKIPDQYHPVVFKSKVISRTHGCFKVDDQGNWFLKDVKSSSGTFLNHQRLSSASTTSKDYLLHDGDIIQLGMDFRGGTEEIYRCVKMKIELNKSWKLKANAFNKEALSRIKNLQKLTTGLEQEDCSICLNKIKPCQAIFISPCAHSWHFHCVRRLVIMNYPQFMCPNCRTNCDLETTLESESESEFENEDEDEPDIEMDIDMEINNNLGVRLVD
The following text describes a protein:
Function:
Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Miscellaneous:
MISCELLANEOUS: Present with 1100 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDLLRILDTKPIPTIVDATTLGISGNTSGDYWLPTTMSLYQKELTDQIVSLHYSDILRYFETSHYKEDVILESMKTMCLNGSLVATHPYLLIDHYMPKSLITRDVPAHLAENSGKFSVLRDLINLVQEYETETAIVCRPGRTMDLLEALLLGNKVHIKRYDGHSIKSKQKANDFSCTVHLFSSEGINFTKYPIKSKARFDMLICLDTTVDTSQKDIQYLLQYKRERKGLERYAPIVRLVAINSIDHCRLFFGKKFDKNSREYLENVTAAMVILRDRLGTLPPDLRPIYSQKLHYLVEWLENPTVPWPLPDIYPLKQYTSMDVERSLLTEVHFKKSDDQLEDAFSNCSKKRGRHGANKAASSTVAGIEDNITPSFYSTKRLKNDYYTNPLKQDMTQLTGITTADNSSNVNYHLSSGIITHKLIQSMGEVYMDICVQKQELDDYSCLDDLQNDHLKFFSNEDEKIIKEYETVLRTNNENLNRSHELEVENNLKFSQIETLEKDIETLKGSLMAQGETLSKLKDAFVKTDNVQDEIEKEERVSVSRDTEKKYMEQEIKRAVDAIRENEEETHKLNEKQNGLESELKLKFEKSEISTKELNEKIGFLKKELKLENDLNEELVGQLSKTMDNLENLTIPRVRTQNGNTKKKSRAKKPGNV
The following text describes a protein:
Function:
Receptor for ecdysone. Binds to ecdysone response elements (ECRES).
Subcellular Localization:
Nucleus.
Sequence:
MYRLNIVSTNPSGSVQQQQQAQGQQVISSVVRPQQQQPPPQLALVQTGGSGGTTTTIIGLTSLNALNATTITGLVAGAAGSSTSAIAAAGASNSGSGPSTATTKHILKAATTNNNISIVKIVDDIMLKAVKVEPLPMDTGGGGGGVSMIPSSATTSGGVTVTAIPASVAPMPPVAAGTNVSSNGSVTVYASGKRRLESNEEWISSPSPGSVPGSAPPLSPSPGSQSTTYTTTMSNGYSSPMSTGSYDPYSPNGKMGREDLSPSSSLNGYTDGSDAKKQKKGPTPRQQEELCLVCGDRESGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAIKRKEKKAQKEKDKVQTNATVSTTNSTYRSEILPILMKCDPPPHQAIPLLPEKLLQENRLRNIPLLTANQMAVIYKLIWYQDGYEQPSEEDLKRIMIGSPNEEEDQHDVHFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDAATDSILFANNRSYTRDSYRMAGMADTIEDLLHFCRQMFSLTVDNVEYALLTAIVIFSDRPGLEQAELVEHIQSYYIDTLRIYILNRHAGDPKCSVIFAKLLSILTELRTLGNQNSEMCFSLKLKNRKLPRFLEEIWDVQDIPPSMQAQMHSHGTQSSSSSSSSSSSSSNGSSNGNSSSNSNSSQHGPHPHPHGQQLTPNQQQHQQQHSQLQQVHANGSGSGGGSNNNSSSGGVVPGLGMLDQV
The following text describes a protein:
Function:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins. Mediates phosphorylation of Cdk1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of Cdk1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MEKHHRLPLPELHDDKHRHKQCNGENSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPSSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQRIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRSRRAVWGRMCNWKTAAFRYLLYFLEVLHLCKPITASQPNINIVPSSPSSKGVPLVPQVEFQLVGSTPIANRDCYASDFLSGEDPLDLSNQGSPNVINSTPLNTNQGKSRLDLLKNNVDSMGRYVHVHDFESPCSALSSAKVLDTSSFRRKKLFVLEYDDE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MTTLPTLPPLPEDIVTGMEELKIVMSAALERQRSQLVQSRQDVNRVLKELEEESKGVSLEIESHMARQHDLRLQISELDKQIEDSKGTIVEYSRRRSELESKVEAAQRACDEGRQRLEEQQSLRRRQVQHVMEQSVRNVPELMYMEDLLGMKIEAVQDDQLRFVFVKLDPNDYAREFAFVLDMADVNYRVEQLEPTLDLSVVDRVVGKLNSSRNFPQFLKEIRQAFKDAIME
The following text describes a protein:
Function:
Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).
Subcellular Localization:
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein.
Sequence:
MERRRSPPKHRHDGTSPLPLGMDWSPPPKKWNGRDTVWPHDPRTGWSYCITIPTWVVLPKSKDSDPVVFYRVVVGLQSPEGVTTTRAVLRRFNDFLRLLAALRKAFPQKNLPPAPPKGLLRLKSRTLLEERRCSLEEWMTKLLSDIDISRSIVVASFLELESAARSSFQDENPQTVQGNRSISNSIESMASGSTPISPDYGSDTAYETSEIGTSSLGRDNISEAGTEELSLDEDLTGPLEKLVKHGMSNIDEGLLMGSAILDQVEGYHSREINRSSDKNGNGGGDYVSEKQQGKLIGNPKKLLNGTTSLPDMEFSSSLADDNIITSSDINLVLPLGQQQKINRVLISMQRRLGTAKTDMEDVISRLNQEIAVKDYLMTKVKDLEEELETTKLRSKENLHQAIQMERERVTQMQWDMEELRRKSLEMEFKLKSQQDDKRETEAPKTTSVIEEKDKLLEELDETKNKFDQLLKKHQELEVKSKADIKVLVKEVKSLRNSQADLKQQLNQSLVGKSEAEKLLQEEKQKFEKEEIGRVNLLHEFDVLQHRLRECSINLLNASEDKLVIDSPSMQDALELIKISDDHIEALLAQVQIIAQDDASTAAGDMNGEEGGRTSSHKLRQMLSEILVDNINLRRQVSMLIHHALSTGIVTTEDKKIDTR
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Binds maltose and trehalose.
Miscellaneous:
MISCELLANEOUS: The protein assumes different conformations with different physical properties depending whether maltose or trehalose is bound to the protein.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MNVKKVLLGLFLVGVLGIAVVASGCIGGQQTSTVTSTPTETSLQGKIVFAVGGAPNEIEYWKGVIAEFEKKYPGVTVELKRQATDTEQRRLDLVNALRGKSSDPDVFLMDVAWLGQFIASGWLEPLDDYVQKDNYDLSVFFQSVINLADKQGGKLYALPVYIDAGLLYYRKDLLEKYGYSKPPETWQELVEMAQKIQSGERETNPNFWGFVWQGKQYESLVCDFVEYVYSNGGSLGEFKDGKWVPTLNKPENVEALQFMVDLIHKYKISPPNTYTEMTEEPVRLMFQQGNAAFERNWPYAWGLHNADDSPVKGKVGVAPLPHFPGHKSAATLGGWHIGISKYSDNKALAWEFVKFVESYSVQKGFAMNLGWNPGRVDVYDDPAVVSKSPHLKELRAVFENAVPRPIVPYYPQLSEIIQKYVNSALAGKISPQEALDKAQKEAEELVKQYS
The following text describes a protein:
Function:
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Subcellular Localization:
Cytoplasm. Endosome. Nucleus.
Sequence:
MSDVRVSSGSPTLEPMEARQTERDHPKPSACRNLFGPVDHAELARDLRRHCRDLAEACRRRWNFDFRNHRPLEGRYEWRPVDRDSLPDFYRRPPPPRRGPRRGPGDPRPTPDPPASRGGPGRGPGRAPDSPDEEPEPGEEDRPRDRPQREEGDGDGDEEGAHLAGRKTDASERQTAFPDRCPAPRKRPAPDDSSPPNKRAHPTEEGVPGGAPGTGPVEQTPEKPSLRRRQT
The following text describes a protein:
Function:
Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSMANFTGGRNSCTFHEEFKQVLLPLVYSVVFLLGLPLNAVVIGQIWLARKALTRTTIYMLNLAMADLLYVCSLPLLIYNYTQKDYWPFGDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLASWHKKKGKKLTWLVCAAVWFIVIAQCLPTFVFASTGTQRNRTVCYDLSPPDRSTSYFPYGITLTITGFLLPFAAILACYCSMARILCQKDELIGLAVHKKKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSSASLPCPTLQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDKMSSKWRQDHCISYGS
The following text describes a protein:
Function:
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
Sequence:
MPSRTARYARYSPRQRRRRMLADRSVRFPNDVLFLDHIRQGDLEQVRRFIRAQKVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLHIACSDGYPDIARYLISLGADRDAANDDGDLPSDLIDPDFKELVELFKGATMD
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MFGTNGNAGIAVTDPTKQAEIYRALESLKKDESGWKKSVDSFIGPHKPSPEEQFLLLQVIEDYLNKRYHSSSQGDVSVIRTFLLHYTKNSRSSTVDQPAFLTNKMAHIFSLVFAADFPERWSSFFNDLFFSDNINDRKVAFFYLKVLLAIDTEVVNRDIQRSKNESDRNIKIKDAMREICINEIAKSWLTIANALPEDNVIQCLVLDNIASYVDWIELDLVANDYVMPLIISKFQNPATSESATAAVCSLLEKGMPAEKKVGLTLTIMTVLRSNGLLTVNDNNDEEEVTRVGSLVNTLGLVLLDVQNKLCASSILEKEQECCVQEMAGLAEPALVVLNNEDPDLSCMCIDYIRAYCSFLLKFHPNETNFIEKVIRAGLQRYVMNDDMTVGGDGEDEVEFQEFRRELRSMLNVIGLKRPEAIINAVEPWTAEVTSGGSSIPVNRIEALLNVIFHLHEIIPSNMLQSPREGISQRAARLPIVILEGLVLDGRCPAIHVLYFELACRYERLLVLQPQPVVIPHIAAAFLDQRGISISSANVRTRIVYLFCRFVKSHKTVLGPLVSEVITRLAPLLAVSPQADTNQLLSPEDQGYIFEATATLIVFGDLTSEMKSQYVGELASTLAMKFENGLVELNTARARKADEETIQAILQFMSNIIGYSSRMSKAFNNAQSMKACNCIDIYLRLIKLYLETLSPQNAFLLESTRQFAHRLVVSMENELMPYMNGIFDKLALVSTDLDSMHHLLIFCHQTVAKYKKAMLTSGVDLGNVLAIAARASLQEQENNIPAKDDSQRALLYVQRAFVQLLYTVIASDCTPALNTTPGLLDHVLESAARLALSSDQTAQKVALSCLAKISLITPSWSARTLRVALEIPSLSHITPSDAGSTLVVHEVCATLTSLHQSDPDGFTRALRELVPNGFSDQLLSALTNLKGKNLDKQVMNLYSSLRNQSAQ
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (By similarity). Required for fusion of endosomes (By similarity). In association with lgg-2 mediates the tethering of autophagosomes with lysosomes to form autolysosomes. Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells.
Subcellular Localization:
Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Late endosome. Lysosome.
Sequence:
MYDAYTPCEVALRLPVEVTCLAFQESNQTLLAGGRAGHLYAYTISANRRGFELTNICKSFHKKAVMELKVCQREDLLLCVSDGQLMAHKLSDPEYKVETLIHKVKPVQTFARFSPKTSGDLYVIVSSRKKLYLFKWGEKDGHKEFIEVALDYNPVFLDTPTSIRCVGEMVFFSVRNEYFSMTMQKDKTTTSPSEGSTPEGWNGFVTRLLNFNCQPGIVPMIDRRRVAFVRNEIVVTTDIWGQRPANVLSDEYKFSEVPMQIVYDSPYLVGMLSKGRVEVRSIFDGQLVQTMSLPKAMTLCSGARGQVFVAALSDIWILDTSQNLRKNVSHLIQERHFELAIQLAENSNLFAEEQKLEIKKKAALNLFNQKKFDESFALFGEIKTDISEVLSIIRMFPELLPDGFQSMTGVVSDMPANDRMRALLALGSYLSEIRTEHAKHIELYNRLYSSGAAKKTDEDEKAKLLLTLRVVDTTLLKCYIKTKPMLVDSLIRLQSNACTFEDAKKILESEGRLRSLFILYETRKKHEMALDLFIDQSSRPDADPFFDDAIQQIVEYLQSLGNSNLPLILKYAKWVLAKNLEAGVQIFTSDETEMARNLNRKAVVEFLKSECPDALIPYLEHVIFKWEEPSSYFHETLLEFYVARVNTLFKDYVHAFPDAFSDENITRAGDEDGELGLYRKRLLKFLEVSHSYSPQTVLLQLAPHAFYEERALILGRLKQHEQALAIYVNTLKNVPAAEEYCRLYYNAHDETNSQVYLMLFRTLVHPNQQQLHSIPYHADSTPFGSYRDDVSEASTLVNSTSSYQPDVNTAIKILAKHADKIDTVGALNMLPATTPLRVVFSAINAVIQTTGRQASTRKMEKSVSQCAMSKKLERKNKAQSTKIIVNFSSECVVCEKKIAVSAFVRYPDGRLAHLYCHNDSQGGNRN
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MNNNNNGGNVISDYPTSSNNNNNGRHNNNNNNNNNNNNNNNSYRRSRSRSRSPSPTRGRSPVMYSPNRDSSDDDSSSSRSGLYLSSSSSRSRSRSPLPPLNNINNGNQQSNNFINNKNNNNNFNNINNNYNNNNGINSSNSNNSSNSSNKSKNSNNNIPNILPYISLNGSGSSSSSKQFSLPPLKSTTTSSSSNSTSSSSSRSSKSHSSSSSSSSSSYPIKSIFGNIGGGSSKGSSSSSSRSSKSSGSSSSRSDRDKSDRDSRSDRESRSDRDRSDRDRSSRSDRDSRSSRDSRSDRDRTSSSSNNNNNNNNNNNNNNSGNNNNSNNNSNNNNNNSNNSNNINNNSNNSRSDRDSRSDRERSGRSDRESRGDSKSNRSSSSSSSSLNNNNNNNNNNNNNPLSSSSSSSNRQPSTTSPIMPSNTLFNIKPIGTTSPHLSSSSNQGLPPISLSSSSKHKLSSSLSSSSSLSSSTNQGASSAISSSISVLSSPKQSPSMKSMSSSNPALPTLAPLTQLSSSSSNQKNLPNLVLKKAISKKDREQLMELLNEHESDSDVDFSTTPTLSSHISKYSPAQSPLPSIKSIPPMPLSGNSFEPLSIGNQRNSTDNLYDNSNNKNNNNNYNNNNNMLKNLDFNSNDHSKLDNILLSEKSIERHRNPLSSSISSAPKPLDFDSDEDITEEYYKKMLANHARSKKSKKETDKIFRELELSDDDVFDEKNDRKQLKMMKRLMDREDNDRRVKKKMVDPKYNSSSSRSKDRYGSSSSSKSSKYNSSSSSSSSRSKDNKYIRPSIFSSDDDFSKDEDDEEFERLWKDRKKKKSSNGPSLSNSYSGIKTDQYNQQQQYNQQQQQYQSQNQQQHQQQQQQIITNQSILEKLDWYKEIDSKFSSNWMKIIKKDLPKACKKYSDIHMNGIANCKKIAQMMKRELKIKNQKPPKATKDNQIRAKKLVKEMGAYWRKFDKDEREAKRRAEKEEANQRKREEEVQEAKRQQRKLNFLISQTELYSHFMSKKLDDPSSGDATPATIGSLMNGSQMPTEQNKKIKEKNDQDDNESSSEEEEESSDDEGKTEQEKKEEEELKSEALKKTQKAIELQLLKTKTFDRDVNKIKNSATEGGGETIPESLAVSDKMMVDGLPMIDMNSSIPPGFSTADTLKQPTILNADLKPYQLKGMTWIVNLYDQGINGILADEMGLGKTIQSIAVLAHLAEEKNIWGPFLIVTPKSTLHNWKNEFAKFVPAFKVIPYWGTQQQRTTIRKYWNPKKLYHRNSPFHVLITSYNVIVRDEKYFHRLRWQYMVLDEAHAIKSSASNRWKTLMSFNCRNRLLLTGTPIQNSMAELWALLHFIMPTFFDSHDEFAEWFSKDIENHAMSQGGLNEHQLNRLHMILKPFMLRRIKRDVENEMPSKTEVEVYCNLTHRQKKLYQSIRSNISITELLGGASFSEQGSMKALMNFVMQFRKVCNHPETFKRSECESPFLFQVQTMEPQNTTSPQCPNHLKTVRSINNNPIQVVIPKLIFREAWNPLNSTDSDQIRTRTIDRFNIFKANNISNNSSGNDTFSFSRFINLEPGELNKLSSELNLLDFYLLNQATENEVYPVFNHLLDSDSFDQPLSNNMKSMLLEPTFSNVLNEDRLNNGLFNVKDLVIGGNERYQINQSVIQYVYTLYPKVTAAPIDAMVSDKSFYIEKSTQQLNSSMDCKEISLVKLTMNGLITNETTKELSESLPTVLPPSSNQIVLDNLKENGGLMGGLNRLFGSTSIWMPSFSKSLNDSGKLQVLDKLLKDLKVGGHRVLIYSQFTKMINILEDFMIFRKYKYLRLDGSSKLDDRRDMVDDFQSDPSIFAFLLSTRACGIGINLTSADTVIFYDSDWNPTVDEQAQDRAHRLGQTRPVTVYRLITKNTIEEKILKRAKQKHQIQSIVIAGGKFESNPEELDQVGENEAISFLLDDDELEERFKNQIDPATGKKRKQPEPEVPSIADKPFSPNDIPTTKPVNKGRPPKEQSKEPKVPKKKGPKPGYKRIKTEAGGGGGGDGGGDTSTASTTTTATTTSSTTSSTNDPSSTSTSPTTSPPPTGVKPTKAAKVPGKPGRPSGKPKGYYKKAPATPTPSNTTLSTPSTSPTMVTTAPIGSANTSPK