lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
Sequence:
MVFEKTLEDLIKGLRQHRGDEESFIASAVSECRKEVQSKEMVVKAEAIAKLTYLEMFGIDISWASFHVIEVMSSSKLSLKRKGYLAAIQSFKSNTDVLMLATNLIKKDMMSANTTEIAIAINGLSHLANISLSRDLYQDVLMLLSHSVPYIRKRAIIVLYKICIQYPEALKTCFPKLRSKLDDPDPSVVNAAVSVICELARKQPKSYLETAPEMFHLLTNSSNNWMLIKLIKLFCSLTPYEPRLIKKLTPPLTELIQTSTAVSLLYECIHTVVSGGMLTGHSHADELAHLCVDKLKGFFEDTDQNLKYLGLLTFKKIAESHRDLVVQHMSLFLKCLIDPDVSLRFRALDLVSDIVDKDSIKSIVKTLMLQLIVNSDYTTENFRQVSAMSIIQMTSKSNYANITDFEWLLSVYIDLARVPNIAVEKELNHQILDLCVRVKALRPFAAELFSRVITEPVFVDKQTESIEPKSNILRAVVWCLGEYAEFLPDAIAVVEALIRPVFYTYPPEVQSVLLWALPKVYIQKFRELVNSWDSEKLTVLSMWAEEIQLFAKHLMSVHHIEVKTRAAEIYYIFTQLLDVFKPSDANATLELLNQPPYILQNTLPVLFTHAPLNPVAFKAQGKVQTPEGLDLNVQINAELVVPEELKKKDVWAYVSALDGTNDVSSRSFELSKLDSFQSSVSGHDRKSPFYLGNDRSSAENLIITDEPSKNENGISVNNDEEMVSQMSTIKTGYSYPITGPVEIAQDELPEGVVLSDTDAEHTSVPLNAKEVPLISFDETLREPNTDDSLIKKVTKVKKSKKKGHRVVLDGETKVKKSSKKKKSSKKKSTL
The following text describes a protein:
Function:
Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (By similarity). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALGLPATPTLAGVGPSEKGPAAARDPAPDAAASLPAGRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQDAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELFLNLTDSPTYNSQETCVMTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSNAFSEKFLEVPAEIARGNIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLIPTNSTNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRSSGAQASSLPTASQRRHSVKLTLRRRLRGQRKMGNPLLHQHRKTVCVC
The following text describes a protein:
Function:
Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity).
Sequence:
MIASADLDACREMIRTGSYSFHAASRLLPERVRAPSLALYAFCRVADDAVDEAVNDGQREEDAEVKRRAVLSLRDRLDLVYGGRPRNAPADRAFAAVVEEFEMPRALPEALLEGLAWDAVGRSYDSFSGVLDYSARVAAAVGAMMCVLMRVRDPDVLARACDLGLAMQLTNIARDVGTDARSGRIYLPRDWMEEEGLPVEEFLARPVVDDRIRAVTHRLLRAADRLYLRSEAGVCGLPLACRPGIYAARHIYAGIGDEIARNGYDSVTRRAFTTRRQKLVWLGLSATRAALSPFGPGCATLHAAPEPEVAFLVNAAARARPQRGRSEALISVLAQLEAQDRQISRQRLGNRANPI
The following text describes a protein:
Function:
Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MPFEKKHFFNDEERTTLLKDIGAKKRFDNAMKIGIVHDTLMSASQPTFLEDSFSYELKNVKIHLPKVNIPKAVALQHEGDRFRKLFQSKPQTARKSLSKEKVSASSLRCLEGRSLLHKSEGQFEEEGMKTAAKILNFNCSKCRNNVRYSPNDLQKHFELWHQGELPSYPCEMCSFSANDFQAFKQHRRIHRSTLVKCEICNDETTYTLLDLTKHFTSKHCVKGNFQCEKCRFSTKDVGTFVQHIHRHNEIQYKCGQCPQVSFTKGEFQRHLLVHSGTFSFRCQYCSYSAMRKDHLIKHVIGSHRDNLYAKEKLEKDNCEKRIMKTPSGLKLILRRYKMGTSRKTLWKRKKMNNASDGSTEKDTQVLKSINKIQRNAEEQNQLLKELHVSEEKTTCNEKQTQNYADSEMRTLSTTQNNKTEEESSSGLGSLKNTVHGPTVLMVKNNKITVPANYSAKFMGFKLVDGKQHIVIKLLPTSKHNLHSSGRQSDEVKVSTTNSQLRPGDTTGLSVPGASLHAHQLNNTVCTMSSTPLSFSALPFSGKVEPGKQKTALAHCKSKSLTGAYESKTPGKSPLHLSTKPELATAPLNLAMKVGPRGSVGPCGSCTTQSHPQVLCTTVTSPVNVESLKTNYPGELKAQNSRMSANYNVNYLNYMSSVDDSSHPPESLPFHNYSKVHILGSPCCSPVGAHENPKGEPLMSQMFSHRSNFGNEPSPSFPALAKGSKNPGSLLESPSQSSRAYRSPDTKDTCGCLKKEPFRDADRPCFVGRGQSNGQQYLHTNENQDFESIPEKSKWDRTSFVNSSSMPKITSVFSLQSKQASHFLSPEVKQVLQEVLKVKSSTHEESHNILDKALKLEQPFWKQEEESNIVTRVKDSTTCCLPFPSSKMGVTVPPRDLNVKDKPTNSVIYYGKERQVPSTSNDFGNSEKISRSSGVNTLLKTQADTVIAQQHVNDKIWATTVNRPVNSEPNKAVFVQSTSKGFLVPLHLANKPGLHVVSGRSRSSTNPPDVYSTSGLPASLLLNKGPGMILTLSNKMLGAAATVPDDSARVSGDATTKEPNKTPLKAERKSDHLTAGLCSSAFGSSPDVTVSSANSMPFKGPYVLSGSAETAVRGIASLNVLPEHRSTVLGTSDSVEQQREFQQKPSLYALVPEGQPTVLLKCVTPHKPKVHKPDIVQDNASSPSPQPKTSEGMQQKILLKIVKTPPAEVLADHQSGNNSRPTLQEDSLQSHKISSAEQKQPASSSDALLFSDRLVPASPSEGPCTATDGSKKSGYPTYHREAQLLRCKTNCTWESGLNNEKPTWNTRNKSSKIRTHLKPKDPETGLACKTRNGRRKTKGDFQEPPKRKVTVRRNCKRKTQTEDALESLGFCRPKLSKDAVRILKLFPFSSKQLVKCPRRNQPVVVLNHPDADSPEVINVMKTITKYKGNVLKVSLSKRTINTLLEPANCNVPNASLDEISAKSMLIFACVSKKKQDAIARD
The following text describes a protein:
Function:
Probable enzyme that may play an important role in cell wall biology.
Miscellaneous:
MISCELLANEOUS: Regulated by SigK. Could also be negatively regulated by GerE. Transcribed by SigK RNA polymerase; MISCELLANEOUS: Inactivation of the ykuD gene does not affect vegetative growth, spore resistance to heat, chloroform and lysozyme, or spore germination in the presence of L-alanine.
Subcellular Localization:
Spore wall. Note=Probably localized either on the surface of the outer spore membrane and/or in the inner spore coat.
Domain:
LysM domains are thought to be involved in peptidoglycan binding.
Sequence:
MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIVIPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQRNPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRVTINR
The following text describes a protein:
Function:
Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA.
Subcellular Localization:
Cytoplasm. Nucleus. Photoreceptor inner segment.
Sequence:
MEDKQETCPKGDSDFVSDKVNFKTEEDDDQTPCHSLEQVDFKSESEDMRQTDSGDEQADIRAASCACQPSGKFLAAESEDDYGSLFSQYSSTLYSVAMEAVTQSLLSSRHISSRKKSPAWKHFFISPRDSTKAICTYCMKEFSRGKNEKDLSTSCLMRHVRRAHPTKLIQENGSLSAGSSFSPPSLLLPPQPADVGDLSTVLSPVRLVQKMAPKIPSPDQIMEESVTVVSSEELSSDVSVTEKYSREEALAGSSPNLSMLHYDDASETMADRNLSLPKSTSGSRRRSAVWKHFYLSPLDSSKAVCVHCMNEFSRGKNGKDLGTSCLIRHMWRAHRSIVLQENGGNTGIPPLYPMPPTLLPALLPPEGDLNSASLSPGKQVKESPSASSSPERLPEDLSSHTNPGDVSREDVSMLSSSDDLGEASVVSSPEKQPADTVNPRFESGTVFQQNKKVMRRLKSEVWHHFSLAPMDSLKAVCRYCSCVISRGKKGDVGTSCLMRHLYRRHPEVVGNQKDFLGASLANSPYATLASAESSSKLTDLPAVVRKNHQGVFPTNSKKTSKLWNHFSICSADSTKVVCLHCGRTISRGKKPTNLGTSCLLRHLQRFHGHVLKNDVSEATLSRSPGIRRPLGIELSGPSSFRDSTEKFYDSHPVAKKITSLIAEMIALDLQPYSLVDNVGFNRLLEYLKPQYSLPSPSYFSRTAIPGMYDNVKQIIMSHLKEAESGVVHFTSGIWMSSQTREYLTLTAHWVTFASAVRPHCEDHHCSALLDVSQIDCDYSGNSIQKQLECWWEAWVTSIGLQIGITVTDNPSIGKMLSEGEHSSVQCFSHTVNLIVSEAIKSQRMVQNLLSIARKLCERVHRSPRAREKLAELQKEYELPQHQLIQDVPSKWSTSFHMLERLIEQKRAVNEVSIECNFRELISCDQWEVMQSVCHVLRPFDAASREMSAHMSTLSQVIPMIHILSRKVEMLFGETMGIDTMLKSLKEAMASRLSATLHDPRYIFATLLDPRYKASLFTEEEAEQYRQDLIRELEILNSTSEDTATSNGCDSGSPLKDTGTEESLWSLAPIKRDQREKLPEDMVLAYLEEEVLEHSCDPLTYWNLKRSSWPGLSTLAVRFLGCPPSTVPSEKLFSTPMDAGSFGQPRLMMEHFEKLIFLKVNLPLICFQY
The following text describes a protein:
Function:
Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.
Subcellular Localization:
Nucleus.
Sequence:
MSRRKQARPSRLLEDDDAPAFPAAAGLDEASPCMDRDMSLTSSQDLPEVLMCQRCQEQFTDVEEYLTHKAECEKKAIKHDDPAHSDPEDMVVSEEDDEDDDAGGKRLERMRRHRQDAANNNSVEENSPEDTSPRLSFPIPIPSAPGHVTLEALQNTKVAVAQFAATAMANNTDNEAALQELAVLQSTLFTLQHQQVLQLQLINQLQQQLQIDRSKAASPVSPPPSENGENAPAEASPPPQNLPVSREPTPTPIIQPPQPIVQEPSENQTTEMNVPCSLPLQSQHCSISSSLASTIITHNNEPPSLDEPNTLEMLQKRAQEVLDNASQGLLATNLADELAFRRNKGSLSPYDSKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPYKCNVCGSRFTTKGNLKVHFQRHSAKFPHIKMNPNPVPEHLDKYHPPLLAQLGQQPSLSPGGPPPHMGFPGGHPFPPTSLPLYRPHGPPPDLLNSRLQPSPHRPQDPPQRLFPPHPLFMKREEQEAPENLTKPARSPTPVRDTHCKSEISDEKREYDDAQSNVPQITPKQEPNDEGEHEPERYSSPAPYDECSIDSKYSNEDTLGARSPGGDHSENMQDEPENLSNKSNSITVPLSISTGQRLPANFSFGQVNSPPSSTSSGSLGQFPATPVIDPAKDPAIYSNLLPRPGSNDNSWESLIEVTKTSETSKLQQLVDNIEHKLSDPNQCVICHRVLSCKSALQMHYRTHTGERPFKCKICGRAFTTKGNLKTHMGVHRAKPPMRVLHQCPVCHKKFTNALVLQQHIRLHTGEPTDLTPEQIQAAEVKDFPSPGGFPSIHNSINPFLGQGFAVPGLSPLGHTLSMNHKYEKIDKEEHESMDDDDDDDDDMSNSENQNPRFTSSPDMQGVPTSMASQLSMSGLSCSAEDLCSTRTAASASPMQNGEKSPCQSGITSPGSSEIRASPNRVTTTPVQVPRPPSSQHAGSPTPSECNSLGALDLTPRTNQPLITSPGPSPGPPPALFSTFGLIPPGQGSTPLMSSALSSLTSSVLTSTAFSPLRLAVGPTGRGNTTCNLCFKTFACNSALEIHYRSHTKERPFKCSICDRGFSTKDGCVCRERRIQDEAEPWKASKRKPASRKSIPSVLPLPMSPGYASNWMHIAGNMKQHMLTHKIRDMPQHMFENKPPISGDENSQQSQQNLPQREVQPSENEQPNPPSQPSISEQNKEQPVKREPTETELPLPKRPPSLQASKHLCHVCNKNFSSSSALQIHMRTHTGDKPFRCTVCQKAFTTKGNLKVHMGTHMWSNGASRRGRRMSLDLPPIPMTPKDSEFLQRRPDLFYPYLPAPFLNGMQQKLNEMSVIQNNQNGMSAAGKYSGLLGFGYPPPEALRSQGGSPDRPERPPSRDPESRSLWDLHFERKSAPEAPREELLPASREGLAA
The following text describes a protein:
Function:
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MTIDRTYPIFTVRWLTVHGLAVPTVFFLGSISAMQFIQR
The following text describes a protein:
Function:
AMP deaminase plays a critical role in energy metabolism.
Sequence:
MNQKHLLRFIKKSYRVDADRVVYDAK
The following text describes a protein:
Function:
Part of the ABC transporter complex OppABCD involved in the uptake of oligopeptides. Responsible for the translocation of the substrate across the membrane. Glutathione (GSH) uptake by mycobacteria through the OppABCD system contributes to the depletion of the GSH pool in infected macrophages, which impairs the ability of the macrophage to detoxify methylglyoxal (MG) and contributes to enhanced production of inflammatory cytokines.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPYSYDDLDFNALLQPPGTKHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATVGAISGYFGGWRDRTLMWVVDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMISSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILAETGLSFLGFGIQPPDVSLGTLIADGTASATAFPWVFLFPASILVLILVCANLTGDGLRDALDPASRSLRRGVR
The following text describes a protein:
Function:
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Also detected in epididymosome.
Domain:
The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
Sequence:
MMCEVMPTISEDGRRGSALGPDDAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQEALNLRDQLSRRRSGLEEPGKDGDGQTLANGLGPVGESSRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSYSRSLPGSALELRYSQAPTLPSGAPLDPYGAGSGRAGKRGRWSGAKDESSKDWDRSTPAGSIPPPFPGELDGSDEEETEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPARETDKTNHVPKDEAGVPRGEGPAIPGDTPPPTPRSARLERMTQALALQAGSLEDGAPPRGSESTPDSLHKAPKRKSIKSSIGRLFGKKEKGRMGPPGRESVSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTPTGNVWMTHEEMESLTAATKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELREQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC
The following text describes a protein:
Function:
Negatively regulates the cuticle development probably by interacting with the HD-ZIP IV transcription factor HDG1.
Sequence:
MTAPNIEMIASSLRNCSLNGGGGGGGGRRRGRRAAAAEGSDDSEGVTVELNSEVALPYHWEQCLDIRTGQVYYINWEDGTRTTIDPRSSSAYSPSPASRSASSSSRRCSRARGRGGGGGAAAAASTTTSSGYTSVSSVGAVTAAAAAWRSHDSSGHGYGYGYGYGSYGYGYGYDGRDGDDEESSSSSSSSSSSSSSASSSRGSAVSSTLSSFSPTDESASGAGSGYAVGDNGAHVLVAAGCRACFMYFMVPKTADVCPKCGSSGLLHLSRNGYV
The following text describes a protein:
Function:
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety. Lacks fatty acyl chain-length specificity as removes both 3-OH C10 and 3-OH C14 fatty acids from lipid A.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKLLPLAVLAALSSVHVASAQAADVSAAVGATGQSGMTYRLGLSWDWDKSWWQTSTGRLTGYWDAGYTYWEGGDEGAGKHSLSFAPVFVYEFAGDSIKPFIEAGIGVAAFSGTRVGDQNLGSSLNFEDRIGAGLKFANGQSVGVRAIHYSNAGLKQPNDGIESYSLFYKIPI
The following text describes a protein:
Function:
Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE.
Miscellaneous:
MISCELLANEOUS: The resulting 3-oxoalanine in the substrate protein is called C(alpha)-formylglycine by many authors. It should not be confused with N-formylglycine.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MAAPALGLVCGRCPELGLVLLLLLLSLLCGAAGSQEAGTGAGAGSLAGSCGCGTPQRPGAHGSSAAAHRYSREANAPGPVPGERQLAHSKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTIDAFYMDAYEVSNTEFEKFVNSTGYLTEAEKFGDSFVFEGMLSEQVKTNIQQAVAAAPWWLPVKGANWRHPEGPDSTILHRPDHPVLHVSWNDAVAYCTWAGKRLPTEAEWEYSCRGGLHNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSVEETLNPKGPPSGKDRVKKGGSYMCHRSYCYRYRCAARSQNTPDSSASNLGFRCAADRLPTMD
The following text describes a protein:
Function:
Catalyzes the dehydration of cis-3-hydroxy-L-proline (c3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts c3LHyp to L-proline, which allows L.aggregata to grow on c3LHyp as a sole carbon source. Also catalyzes the epimerization of c3LHyp to trans-3-hydroxy-D-proline (t3DHyp), a competing reaction occurring from the same enolate anion intermediate. L-proline, t3LHyp, t4LHyp, c4DHyp and their methylated derivatives are not substrates.
Sequence:
MKITAINVFQVDLPLREGRYSWSNGNFVEVFDSTVVEIETDEGLKGYAECCPLGSAYLPSYALGVRSGLQELAPHLIGKDPLNIGEINRVMDAALRGHPYAKAPIDIACWDLLGKATGQPLYTLLGGAAQDDVALYRAISQEAPEIMAKKIEGYAAEGYTKFQLKVGGDANDDINRIHATRSVLKKSDLLVADANTGWTRHEAARVVGAVSSLDVYIEQPCLTYEESVSIRRRTALPFVLDEVIDGPNTLVRGIAEDAMDCINLKISKVGGLTKAKLMRDLCIAHGIPMTIEDTWGGDIVTAAIAHLARSTPSEFTFSATDFNSYGTVDIAEGAPKRVNGRMTTSDLPGLGITPIFDVLGEPVARYS
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAGQDRASVVASGFLTLLASQIGTRLVTFIINLLIARHLSPEAYGLSSVQFHLLTTTALFISREGFRRGCLRFGGGAGADDDADAASDSSKSSNGAKGSAGKHSNGSVGKDSSSIQGSGIDNRAVLRVAWLVVPLGVVVTAAVCGLAIWRHDAAVAAAAASTGAATANGRGESAAVPYYREAVLLHGLAALVELAAEPFYILASVHLMFGARVGVEFASTLTKSLVTLGLLSLPSLAPALLRRLGLALRPVEPPAGSAARSAATGLPPALVFSAAQLALAAVALAGYGAVGWRLLRADKRAGARSSWLSRWTPQELRVLGTSAVFTLQAVEKLALAEGSKVVLATMQSAVNQGVYGLVSNLGSLVVRTLFQPLEEAAFAAFSAWGAEAAAEAATKESVAGSAAEGPTAAAAAPPGQGSAGTKAAAGGRKAEPSKAAAAAAAAERRLAPLAAALGPMVKAVCVLGLAAAAFGPAYAYTLLRLVYGTRWSETEAPAVLAAYSVYVLLLALNGIGEAFVHAVLDARGLQASNALLLLFAGAHVGACVGLVGRLGALGMVAADAANMVLRIAYSAWCIRRFFRPLPCFSLRRDLLPSSATLAAFAVAACAAGVSNYIFLVAPGVDGSTPQRLFLRRAAPHVAVAFGLLAVVGGVMLRAERATLRQVMEMRRRRGRGSEAMASKKED
The following text describes a protein:
Function:
Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MGITVMARIDNYEQRFGGIGRLYTPDSLARLRQAHICVIGIGGVGSWVVEALARSGIGELTLIDMDDICVTNINRQLPAMSGTIGKLKTEVMSERVKLINPECTVNIIDDFISPENQSDYLNRGYDYVIDAIDNVKTKASLIAYCKRNKINVITIGGAGGQTDPTQIQIADLSKTIQDPLLAKVRSVLRKDYNFSQNPKRKFSIDAVFSTQPLIFPQMTEGCSTSATMNCANGFGAATMITATFGFFAVSRVIDKLLKKKS
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKLKDISRTATFAWDNTSSSAPLLATGAVAGALDESFSNESQLEIWQPDFGDVSNVKLGGEGKPALGSITVSSRFNQLAWSAPSTTHMKGVLAAGMETGEVNVFDPSKIVTGASADEARIFKSEKHTGPVRGLDFNSIQKNLMLTGSVNAEIYIYDLNSPNNAPIPPGPTSTKLNEITALQWNPTVSRVFAASSSSGFTSVWDLKAGKEIVSLQYGGGAAKGMETVGGVAGLQMGKRRGMSDVCWHPEQATRLITASEDDESPIIMLWDLRNTRAPEKILSGHHKGVLSVSWCKQDADLLLSCGKDNRTLCWNPQTGEIIGELPTSNDWSFQTSWCPRNPDLLATASFDGHIGIHSLQTTSIPSQSTEKLSEAATADDVFGALGNEQPQDETVNVLSLKQAPKWLRRPVSATFGFGGLLATTSNLPGASGKHQSGVVHLRTVTTEQDVLNRAKALDQTDGQQEKLAKFCSERAKDDDEAWKALQALFKANSRQELVQLLGFSQEEVAKKVQDAIKKFPNAIKAAGDATPVIAPLEEESVKTPTAEKPEAIEDVSTTSDAGVESHDDKSEKSETKKSENGLFDDETAPGTPAAAAAADFFSSMASGALRNPQLDSIVSHKSEAAESSVAATVGSRASSVRDEIVNKENTFQIYPEGESDIDKLVTQALVMGDFKSAVDVCLAFDRFADALLLAVRGGPDLLQSTQNAYFAQQTTSRPFLRVFQSIVTEDLLDIVQNADLSEWKVAFVVLCTFAKDTDFGNLAEQIGQRLQYRWRVLSASDSSEAKASAKIARQDATLCYLAAKKLEKVVSIWVDEMAEEEEAVSATRYTSHAQALQSFIEKVSVFKAATGYVDEDLLTPTESAAAAEAGARTYKLAGLYDRYYEYADLLATQGLVDIAAKYVKMTPVDYKGSEQVGELDKARQRILSAAGGNVGTKMAQTTGKVQSTAGSSIARGYAPAQQASAYASSQPAYALQQPTTYAASTAPAYQAPPAASGPYQPASTSTAYAPPQPTPSYGDSNPYAPATVYQPSSGYPPNGYRPSDPQPQGYGAPQPSFGQTQAMPPPPRVGQTNAPISSPPLIPGSQQRGISGWNDAPTFAPKRPQSAAKDVKKASAILSPFPNSADPLAAAGAGLNTAGAAPPPGRSPQPGVIPPPPKNARPPSIAAKVQPPPTVQQQQQFHQHAQHQQQQRQQQLTSPPAAAGPPPSAFSRPPPPGARAGPPPGAFAGPPPQRALSPLGPGRLSSPPGSQIRPPSAVQRPPSQPGQVQSLDGGITGMGGPPPPGSRMAGPPPGRSATPQQQQRQQIIPPATSPSQTKIQSPSSEQVKPRHPAGDRSHIPEASKPIYEILSGELTKVKQSNIPPHVKRIVDDTERRLNILFDGLNNETVPKQAVDMMNEISKAIAARDLNAALAMHVELLTTASGDMTSWAPGVKQIIRLGA
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Sequence:
MNGNEEGDGLIEFYASEALTCPRRIYFRLKGYPQKWPEFVRVRLNQGINTHQILGQILQERFGVELEKHLVLRSSKLGFEIHGRIDAFKDFPIEIKGKTSLPKVPYDYHLAQLNVYLRWAEAEYGYLYYIKLHEEPMKIINKLDISSFPVIKGPNFRVFEVPYDKSLFKETLRHFYKVKKAYENDRLPEGWKSYACRFCPYRHICYPDRDWEDSE
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Miscellaneous:
MISCELLANEOUS: Present with 593 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAVNPELAPFTLSRGIPSFDDQALSTIIQLQDCIQQAIQQLNYSTAEFLAELLYAECSILDKSSVYWSDAVYLYALSLFLNKSYHTAFQISKEFKEYHLGIAYIFGRCALQLSQGVNEAILTLLSIINVFSSNSSNTRINMVLNSNLVHIPDLATLNCLLGNLYMKLDHSKEGAFYHSEALAINPYLWESYEAICKMRATVDLKRVFFDIAGKKSNSHNNNAASSFPSTSLSHFEPRSQPSLYSKTNKNGNNNINNNVNTLFQSSNSPPSTSASSFSSIQHFSRSQQQQANTSIRTCQNKNTQTPKNPAINSKTSSALPNNISMNLVSPSSKQPTISSLAKVYNRNKLLTTPPSKLLNNDRNHQNNNNNNNNNNNNNNNNNNNNNNNNIINKTTFKTPRNLYSSTGRLTTSKKNPRSLIISNSILTSDYSITLPEIMYNFALILRSSSQYNSFKAIRLFESQIPSHIKDTMPWCLVQLGKLHFEIINYDMSLKYFNRLKDLQPARVKDMEIFSTLLWHLHDKVKSSNLANGLMDTMPNKPETWCCIGNLLSLQKDHDAAIKAFEKATQLDPNFAYAYTLQGHEHSSNDSSDSAKTCYRKALACDPQHYNAYYGLGTSAMKLGQYEEALLYFEKARSINPVNVVLICCCGGSLEKLGYKEKALQYYELACHLQPTSSLSKYKMGQLLYSMTRYNVALQTFEELVKLVPDDATAHYLLGQTYRIVGRKKDAIKELTVAMNLDPKGNQVIIDELQKCHMQE
The following text describes a protein:
Function:
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MNNHVSSTPSTMKLKQTINPILLYFIHFIISLYTILTYIPFYFLCESKQEKPNQIKAKPVSSKPDSAYRSINSVDGLASVLYPGCDTLDKVFMYAKNKFKNKRLLGTREILNEEDEIQPNGKIFKKVILGHYNWLSYEDVFIRALDFGNGLQMLGQKPKANIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHGLNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGVIVHTMAAVQALGVKANVEKKAHSKPLPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEIMDRIYKNVMNKVNEMSAFQRNLFILAYNYKMEQISKGCSTPLCDRFVFRNVRRLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESTGAGTITEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQNVTMGYYKNEAKTKTDFFEDENGQRWLCTGDIGEFDPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLIDNICAYANSYHSYVIGFVVPNQKELTELARTKGFKGTWEELCNSSEMENEVLKVLSEAAISASLEKFEIPLKIRLSPDPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK