lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
Subcellular Localization:
[Isoform 1]: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A; [Isoform 4]: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery.
Domain:
The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL); The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2) and localization to the cell membrane.
Sequence:
MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAKNNFYLCIHCGARNEALFRVFTKSALTLQTCDDCNMIIDKYVEYDFTTIFIDILLLKLSAYRHVLYNSNSKSYLSRLVALTLLSFSYVEWVHQKGKKEHRSEPIFYELEWGYYLIIGQEFIKAALFSLTFLLFGFISSKLIMQQELFSCKHMLHGMAMSYCWNLVTIPSLVWNHYSTYHILSQIALLISCNHTFHVCICPSYMLSIITIVCAWVVQWSAAHGLQRMHLFS
The following text describes a protein:
Function:
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin.
Sequence:
MGESKNMVLNGRRHGRKFSSNQPVSKSRLQNTQRSHLRQNKGSPSVRRCSRRCGGAPPEAERRHVPSSGMTAKELCEYDDLSTSLILDPYLGFQTHKMNTRFRPIKGRQRELREIIELFKKHDNLEKAFQALTSGDWTRHHFLNKTKSQEKLFKAHVFVYLRMFASDSGFEILSCNRYSSEQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSKPGLPVEAPVINSKYGLRETDKRLNRLKKLGESCRNSDSQSVSSNAEADSQEPTTVQTSLRKRTSQSCVKKHGEAKAVTRQTLSSTPSSTSSSKRSQANISSLPKRLKSKPTQTLSKGRRRCRGLWTKGSSRVSASGNLKESSRRDTDRRRSASKGSVARSSENNRSSSKGASPCKDSTLCPYRTRRSTRTSLGAQGAEGTEASNHPASPSIVLKSEPGEFIPVTLGHQMSTPSLDSSCPKKGTCPRRRRTVKQEDSYGESFVQEGVPDLRHAVRAADVADCGKVVLGLPDRHQHYNGSSKSSKALRRGKGKKKRQITRYDAQLILQNNSGIPKITLRRRRDSSSSKNEPRETSSSSSSKISIKFSKEHEKDRSSSYVAKLNNGFSHGPHSSSTKLKIQLKREEDPASLHRTYPEDVTLGIVQRDAADVLDHKAAAQVGQDMEVESMSSEDDDDDYFDNEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
The following text describes a protein:
Function:
Required for telomere maintenance.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MDSAKLIFINQINDCKDGQKLRFLGCVQSYKNGILRLIDGSSSVTCDVTVVLPDVSIQKHEWLNIVGRKRQDGIVDVLLIRSAVGINLPRYRQMVSERQKCD
The following text describes a protein:
Function:
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.
Subcellular Localization:
Nucleus.
Sequence:
MEVSETDEHLTRLNQARDIVKTDQSLFPEIVRNILSVANYSDIRYKKWMANFLWFGFSSKNVKFEQKLDLAVTCLDTIVSLYAVDNEEVKKDVISCSCTIYPLVFLHCCTSPNDSSTWDTLTKLKNEIINDFDKGNKPLLISCIKFISCVILTQVPGIRDPRLVTKSDVSLSKVPTHHPFINSNILRIEANDLIEKIFSILFSDSLNVLYITSVLNILPVLVKRRKELAPKIIGSLLEFHLPNPKDEIELSNESKLAIRCIEKNLKLILLHLAKSTGASSSSVEKIHAYLSGQIYHTKVDESLKKRQYEGNISAASKRVKSSAVQSLVERMQPQLSSHDGLQNNPLISIFASQTAINPLANFDVTSIPVEVATEIVLTSLLKIDKNYFHQQINMLRERVRSLSEPESLGLDQQVDEDEDEDYEPPEVDVQTINASVEREAARLEGSAPSNVVTDAFELPTPDSLSPMAILEYFHGALSRLFDYAPQFERSIVSSSNLQNLTLENVDNTVWDKRHWAILLPRLCTRGLLNYQPVTSGEESGDASFTLSSFVRGQLFTYVASNWRSSTNLILNWLSEEWYNDRLMLENPDCHEYEDVKWEGPQYEKWALKVIDSILPYLEAKDKVFMIFMSELPELTDAIVDKIKFVCLDPDKTKLGFMTFQYLIMFRLTCT
The following text describes a protein:
Function:
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
Subcellular Localization:
Secreted.
Sequence:
MRGAVHIFIMLLLATASDCAVITGACERDIQCGAGTCCAISLWLRGLRLCTPLGREGEECHPGSHKIPFLRKRQHHTCPCSPSLLCSRFPDGRYRCFRDLKNANF
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MSAAAACAPTRRLGTTMLTFAARLPESPEETEARRGAAAEPRGRDVDVHPRLWQACAGSMRAVPPVGAAVYYFPQGHAEHAGGAAVDLRVPPFVPCRVAAVRLMADPDTDDVYARIRLVPLRAWEPVADVGDAALVKTDGSSRGGADGDGDGDAGGGQQQQPRPLSFAKTLTPSDANNGGGFSVPRFCALSIFPELDYSFSPPVQFVSARDVHGVEWTFRHIYRGTPRRHLLTTGWSNFVHNKKLQPGDSVVFVREEDGKVHIGLRRAKRVFCRRGGGGSNAGVAVAGPSDGKVPAEDVVEAARLAAAGQPFEVVHYPRASAPEFVVRAAAVKESMQAPWCPGLRFKMAFETEDLSRISWFMGTIAGVEPADPARWPQSPWRLLQVTWDEPELLRNVNRVCPWRVELVSSMPKLPRFSPPPRKKPRTPSYTETRSERQQLFDPAFPFPPTHPLPLAPPSLALLPAPNHDGNRHDFVPSFPVIPDSIAAAGIQGARHLQFAPFFSDLHLSDLQRSLLFSGIQPADHQAPPAPRIATGLKIGSPAPRSPSSEAKNGDDVKPPVIMLFGREILTEEQMKSNSSTRSGSSKPDCDDEKTSSTSDRSGSDVSHGSPAKKNSPSLTLWWSGDSSLSAFALEPGQCKVFVESDTLGRNLDLSALSSFEELCARLSSFFGINNADLRSHMVYRTIAGEVKHVGDEPFSVFVKSARRITILTDAGSNNTGK
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Sequence:
MEETLTPNPKQRPTSTANTRIQAPTSPFFLGSNNDRLEREQARAARVAASRRRSVVFGRGPQLEKESDPCFDKQQILELFQNCIKLASENKINQKNTWELNLIDHLCEIIKVEDENNAETNFQKASCTLEAGVKIYSMRVDSVHSEAYKVLGGITRAGHDDTGDNEDAAGSVVTATNQKKQAEKKLSPLSTLEPSFDALNVKKFDVAFAVDPLYHQTSAQFDEGGAKGLLLNNLGVYGGCQVLFDSQEIPGKLVSSANQHDKSETIDLSFARECVEKMVLNMRQKDEIVPSLRAIINQFDEENQRPSDTFSCSQKTTESFDISHDNEASYADNDDGYDNFGDSFNYEGQSGAAEENFGLNDAEPAYSNFPEEVEPASLQDLDSDERFENVDDYLFLSLGISSKQNSWAGPDHWKYRKTKGPDVHPASENGSSPPVKKTRKKKQAEPELDFTKALEEEIPDIFAPPKNLKSLLLPANRAPCQTKLPEDCHYQPENLVKLFLLPNVMCIGKRRRKCSGETRQQYDDYEHAESWANDNVYDDGPFDNGNDQSDAEDTTNSLISQPRQVNKIEVQYDKASKQVDVQVLKETLWECLQESPQPPIQDKEHQQEAPESRSFKELLASFPDDCKAAGTTKDISPHLCFICLLHLANEHNLSLIGSQDLEDLTIHLA
The following text describes a protein:
Function:
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Vesicular and vacuolar.
Domain:
May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
Sequence:
MVLAHSINTNPNTNTNTNNTSTTSSTTTIPNDSKILCINFNQDQGCFAISHEQGFLVYNTDPIELRVKRNFIVNSHTTSSRSNHSNGSNSNNNHRNNSTGSNGSVSSSGSNNETTLGYKSTHKSASGSGSGSGSGIGHISMLHRTNYLALIGGGENPKFPINKLIIWDDLKRKTSLSLEFDTPVLNVLLSRVRIIVVLIDQIIVYGFAAPPKKFQTFNTINNPLGIADLSVNSQQSNVHLYNNYSSNSAQAQVSGTTTTTHYDFSKRKSLSPTNSSNSSSTSLKENGTNLTTYPSPSSTTSASASVATITNTPEAATTANPTTATTTATTTATTTTTTTSAKPLVNGIGSSYQTLAFPGRSMGQIQIVDVGNNHHSGTNIKPTINIIKAHKSNIRCLCLNRTGTLIASASITGTIIRIHSTRTTALLYEFRRGIDRAIITSMKFSHDDSKLAVLSDKHTLHVYNIDETQYPNDGGSGGTKDGGGGGRGSKNRHHLLNGLLPYLPNYFQSTWSFCSVNTNKYHTSDLEDNSQQQQQQWVANGTGGGGVDEGVIGWSGNDSIIIIWKLKKIWEKYVIVETENHQYDLIRSSWKRLDS
The following text describes a protein:
Function:
Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
Subcellular Localization:
Cell projection, bleb.
Sequence:
MAERAGEEEGGVARSPLKRLRDPLSDGEQSRKSEAPEPQEVFKRRCYDVSGDENLNPMEQARSPLKPLHRQVEMVVKPDTPAVASIKSRMNTLAAQRQQDEPSAVSGLEDQSGDQAALETAVRGDVEFRSRVERFEARTPATEPIAPTSRPHSQSSIARTIQEKLLNSQGSSVSKANRLRKEREEELRLVRLQSKSDNIWKKNDAEASLMEDAVVKADSQDSERKESDTANCSSAMYVSDADLTSQEEELNSSEMIDQIFEGVLDTTEDEVEPDCDDNGMSSREETEEQSGQQVTQEGNVTTENSNNEQADDEKEKAEVDKHGDNNVDEELTFPPGSILSPLTKSVEAVVTPLRLMSGDAPGPIPFHLTPSDLTETPPLYSIDAYRSLRQSTLRSYNSVTPTTNRKATEQTRTAQPHSVKEKIKILNEEISKLQTIIYQTTQALNCCTDEEHGKGSLEEAEAEKLLLVSMEKRLSLLSELSRLKEPGASAGSAERGLETSPQEPCRGTLSISDVRLPLKVEFACSARTRAGRPSHYFFVLIRYGSSNIVATPLATAADAKNGDTIAFPTSITLQDIRPNFEIDVEVYSLSHTTNACNSERRPSKSKVTPKKLLTNITKSNHNQSSAVLPALGSSVRASNFSLVGSHKITLTSLGQNKFPLDKIKFDGKVRKLLGDEFQEKVPFLSPLEGNIYLRLACQSHSNIEHRGFLTMFEDISGFGAWHRRWVCLERGNLSYWNYPNDERSKPAVGCINLTNCTSQCVKPVNRDSCARPNTFELVKLSQQKDAREILSKCWFSADTKEEREEWMEKLNQALLDHRTWKPVVSDQQTRQRDAPQDMSFTSTHSRESIL
The following text describes a protein:
Function:
Involved in calcium binding and microtubule stabilization. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein.
Sequence:
MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKCVSTKKWVEISNVKMESVGIIPCFMPLGQLEWVLQQSFENEGAGLFSWGSKECCDSHVKDFYGIEKLRMDLQET
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular Localization:
Nucleus.
Sequence:
MSSVSSSISVVEIPSIKQTLEKKTVSTKRPTTDAPGKRKRGGFVARMIPEQLQIFKGLVFLTFSATVFFPNSDVSPLRRLRIQRAQEYGALWAKTWGSHVTHIIVDKGLSFEEILKHLELETIPSDVAVVDEAYPAECIKFRCILRAAQVRFQVKGAPSAELPRLDTLQPESQSVLTQWSPPLKPDGRQLGQTQRSSQLSVQEDPSLEQAPQLDIYCEASGKIVRGSSPVREHDALNDVIEEAKATEHLPLDPLDTSDDDSAAEKSGYETSDESQSPPAKTKSRKLSDGQNGVARCWQQKFVCMQKHDSTSSAQNPNARTIEVLQQMLDYYTRTADHWRTLAYRKAISALRSQSKKVLSRSEAIRIPGIGERLADKIEEIVLTNRLRRLDNTSNTVEDRLLQTYLGVYGAGITVASRWIAQGYRSLEDLRTKASLTQAQRIGLDHYFDFSQQIPRTEVQAHGNFVRRVVRMESPDMQVIIGGSYRRGAATSGDIDLIITRPDATIEEIRTLMLDNVVPKLFQQGFLQASLAATCRGEGSKWHGASKLPDGQLWRRIDLLFVPGAELGAALIYFTGNDIFNRSIRLLASKKLMRLNQRGLYADVPRASQRTKVNPGRLLESRDERRIFKILGVPWRPPEHRNC
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. The DASH complex mediates bipolar kinetochore-microtubule attachments and facilitates the formation of additional interactions between outer kinetochore components and spindle microtubules. During chromosome movement along the microtubule, it is required both for the sliding of kinetochores along the lateral side of the microtubule and also for microtubule end-on pulling on the kinetochore. Modulates cytoplasmic microtubule dynamics by tracking the plus-end of shortening microtubules and slowing their depolymerization.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Note=Associates with the mitotic spindle and the kinetochore. Kinetochore association occurs only during mitosis (By similarity). In the cytoskeleton, localizes to cortical microtubules (Probable).
Sequence:
MSYLDGLQQCVDSLQISIGTLSSSIDTLESGIHDFPRIKHILKVQRHFNLISEDELSARQAKFEEIVKPILSKAFQRLEDSISSLQRQEDSLKTKYELQEARLDMLKNRPATSAFSVTTESSEQLKAIIAKRQKLVYTLERYTLQLQQKRGH
The following text describes a protein:
Function:
Involved in the transposition of the insertion sequence IS3.
Sequence:
MKYVFIEKHQAEFSIKAMCRVLRVARSGWYTWCQRRTRISTRQQFRQHCDSVVLAAFTRSKQRYGAPRLTDELRAQGYPFNVKTVAASLRRQGLRAKASRKFSPVSYRAHGLPVSENLLEQDFYASGPNQKWAGDITYLRTDEGWLYLAVVIDLWSRAVIGWSMSPRMTAQLACDALQMALWRRKRPRNVIVHTDRGGQYCSADYQAQLKRHNLRGSMSAKGCCYDNACVESFFHSLKVECIHGEHFISREIMRATVFNYIECDYNRWRRHSWCGGLSPEQFENKNLA
The following text describes a protein:
Function:
Stereo-specific NAD(H)-dependent 3-oxo-delta4-cholenoic acid oxidoreductase involved in bile acid 7alpha-dehydroxylation.
Sequence:
MSYEALFSPFKVRGLELKNRIVLPGMNTKMAKNKHDIGEDMIAYHVARAKAGCALNIFECVALCPAPHAYMYMGLYTDHHVEQLKKLTDAVHEAGGKMGIQLWHGGFSPQMFFDETNTLETPDTLTVERIHEIVEEFGRGARMAVQAGFDAVEFHAAHSYLPHEFLSPGMNKRTDEYGGSFENRCRFCYEVVQAIRSNIPDDMPFFMRADCIDELMEQTMTEEEIVTFINKCAELGVDVADLSRGNATSFATVYEVPPFNLAHGFNIENIYNIKKQINIPVMGVGRINTGEMANKVIEEGKFDLVGIGRAQLADPNWITKVREGKEDLIRHCIGCDQGCYDAVINPKMKHITCTHNPGLCLEYQGMPKTDAPKKVMIVGGGMAGMIAAEVLKTRGHNPVIFEASDKLAGQFRLAGVAPMKQDWADVAEWEAKEVERLGIEVRLNTEVTAETIKEFNPDNVIIAVGSTYALPEIPGIDSPSVYSQYQVLKGEVNPTGRVAVIGCGLVGTEVAELLASRGAQVIAIERKGVGTGLSMLRRMFMNPEFKYYKIAKMSGTNVTALEQGKVHYIMTDKKTKEVTQGVLECDATVICTGITARPSDGLKARCEELGIPVEVIGDAAGARDCTIATREGYDAGMAI
The following text describes a protein:
Function:
Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
Sequence:
MDGVAEFSEYVSETVDVPSPFDLLEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNILVDGGSDRKSCFWKLVRHLDRIDSVLLTHIGADNLPGINGLLQRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPDKLRLPDASRKAKRSIEEACLTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNPVKDSKEMQFLMQKWAGNSKAKTGIVLANGKEAEISVPYLTSITALVVWLPANPTEKIVRVLFPGNAPQNKILEGLEKLRHLDFLRYPVATQKDLAAGAVPANLKPSKIKHRADSKESLKAAPKTAMSKLAKREEVLEEGAKEARSELAKELAKSEKKAKEPSEKPPEKPSKPERVRTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKRDKEKKEIKKERKELKKEEGRKEEKKDAKKDEKRKDTKPELKKFSKPDLKPFTPEVRKTLYKAKAPGRLKVDKGRAARGEKELSSEPRTPPAQKGAAPPPAASGHRELALSSPEDLTQDFEELKREERGLLAEPRDTELGEKPLPADASEQGRPSTAIQVTQPPASVLEQEQVEREKEVVPDFPEDKGSKNRAPDSGAEVEREKETWEERKPREAELTPENIAAAREESEPEVKEDVIEKAELEEMEEVHPSDEEEEETKAESFYQKHMQEALKVIPKGREALGGRELGFQGKAPEKETASFLSSLATPAGAAEHVSYIQDETIPGYSETEQTISDEEIHDEPDERPAPPRFPTSTYDLSGPEGPGPFEASQSAESAVPASSSKTYGAPETELTYPPNMVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSVASLTAPQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKSPPCEDFSVTGESEKKGESVGRGLTGEKAVGKEEKNVTTSEKLSSQYAAVFGAPGHALHPGEPALGEVEERCLSPDDSTVKMASPPPSGPPSAAHTPFHQSPVEEKSEPQDFQEDSWGDTKHAPGVSKEDAEEQTVKPGPEEAMSEEGKVPLSRSPQAQDTLGSLAGGQTGCTIQLLPEQDKAVVFETGEAGAASGAGSLPGEVRTQEPAEPQKDELLGFTDQSFSPEDAESLSVLSVVSPDTAKQEATPRSPCTPKEQQLHKDLWPMVSPEDTQSLSFSEESPSKETSLDISSKQLSPESLGTLQFGELSLGKEEKGPLVKAEDNSCHLAPVSIPEPHTATVSPPTDEAAGEAGLTDESPAGNLPGSSFSHSALSGDRKHSPGEITGPGGHFMTSDSSLTKSPESLSSPAMEDLAMEWGGKAPGSEDRATEQKEKELERKSETLQQKDQILSEKAALVQRDSVMHQKDEALDEENKPGGQQDKTSEQKGRDLDKKDTAVELGKGPEPKGKDLYLEDQGLAEKDKALEQRGAALQQTQAPEPRARAQEHRDLEQKDEHLELRDKTPEEKDKVLVLEDRAPEHIIPQPTQTDRAPEHRSKVDKEQKDEASEEKEQVLEQKDWAREKEGAALDQDNRAAGQKDGTLKEDKTQGQKSSFLEDKSTTPKEMTLDQKSPEKAKGVEQQDGAVPEKTRALGLEESPEEEGKAREQEEKYWKEQDVVQGWRETSPTRGEPVPAWEGKSPEQEVRYWRDRDITLQQDAYWKELSCERKVWFPHELDGQGARPRYSEERESTFLDEGPNEQEITPLQHTPRSPWASDFKDFQEPLPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASPPEMTGQRVPSAPGQESPVPDTKSTPPTRNEPTTPSWLAEIPPWVPKDRPLPPAPLSPAPAPPTPAPDPHAPAPFSWGIAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGEREGEGGAGAPDSSSFSSKVPEVTESHTTRDAEQTEPEQREPTPYPDERSFQYADIYEQMMLTGLGPACPTREPPLGASGDWPPHLSTKEEAAGRNKSAEKELSSAVSPPNLHSDTPTFSYASLAGPTIPPRQEPEPGPNVEPSFTPPAVPPRAPISLSQDPSPPLNGSTTSCGPDRRTPSPKEAGRSHWDDGTNDSDLEKGAREQPEKETQSPSPHHPMPVGHPSLWPETEAHSSLSSDSHLGPVRPSLDFPASAFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALVPGTPTRTRHDEYLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFPPGLEVAEQSSGELGPGNEPAAHSLWDLTPLSPAPLASRDLAPAPAPAPAPSLPGNLGDGTLSCRPECSGELTKKPSPFLSHSGDHEANGPGETSLNPPGFATATAEKEEAEALHAWERGSWPEGAERSSRPDTLLSSEQRPGKSSGGPPCSLSSEVEAGPQGCATDPRPHCGELSPSFLNPPLPPSTDDSDLSTEEARLAGKGGRRRAGRPGATGGPCPMADETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPPPAPLPDPRPPPPRPDVCMADPEGLSSESGRVERLREKVQGRPGRKAPGRAKPASPARRLDIRGKRSPTPGKGPVDRTSRALPRPRSTPSQVTSEEKDGHSPMSKGLVNGLKAGSTALGSKGSSGPPVYVDLAYIPNHCSGKTADQDFFRRVRASYYVVSGNDPANGEPSRAVLDALLEGKAQWGENLQVTLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVMQDESFPACKIEF
The following text describes a protein:
Function:
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Sequence:
MAKAPVRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MTDLQSFYHSSVQPKGGDIVVATLGNSGSTFAVATAKRMVSVYVLGQSEPTLTFKDFNSDATSILFSYDESLLALGTMGGSVHVYDLKAKSCYWRFSAHKSYITAMAFTQSGMFLATGSIDGSIHIWDTSKRGKLQDIASCNSQPIVPPTGIKGSARLTSVVNDPAITALTFPSSGAFLFIGDAAGRIFIWNTVSLAFIQELMATSRSGNSSEDLSLTNPHISQNSNQLLQITKVSIKHITAHDEHKIIAVCDGEKVTYWDVGAFSEITKENRAGGCDWSYFMNNSDVSLVFHPHGMLCVDYEAEQEHVLSSVPVNLDNLFSVAIRRSSRLPQVVMLLLEQSTTPSVSIWVINLKYVEPFKTLYAHLIGDKATEGGKPMKKSSDTASTASIQQPKPAEKRQKPPQSTSVVPAPNPNGRNRPHEKDDKRPAEPKRTSASATPESDTIAQPTVYSVFDYNKIQRKPGDTDEMLSVLLGNTEIIESMEHKSIIVGVFSDLWHEGNIKVAIETLLQEKDMRVVCDVLKKIDARNGISISDILPVLIHFSASIEHAIASKDPSITAIYNATDSMSLSVNYAKIFSQVVFSTIQAYSRTSANANDVALEDRYDNCIKFFESMCTIKGLCEDASVQSTSSKIKASAKASAATLRDLRFTK
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEHLVRRRYWWFAFSLLIILPGLYMLFLHPLLTTGRPGIGLRPSIDFAGGALWELRFPDVTPETLSTDRIAQAFAEAGFESAQVQLSPTVIDGQPVAAALVRTRPLSESDPNAEIDAVTKALTDAFGTVSRERLESVGPTVSAESTRSAIIAVLGASLIILLYLTWAFRKAPHPFRYGVCALIAMLHDVLVVLGIAAILGATIGLEVDALFLTALLTTLSFSVHDTIVVFDRIRENLINRHPAETFDDIVNHSLVQTLPRSINAQLTTFFTLTALLLFGGDTIRNFVLILLIGLVSGTYSSIFNAAQLLVVWEHREWRNWFKRGRQDEVEVRSGA
The following text describes a protein:
Function:
Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
Subcellular Localization:
Nucleus.
Sequence:
MSRHSTSSMTETTAKNMLWGSELTQEKQTCTFRAQGERKDSCKLLLSTICLGEKAKEEVNRVEILPQEDRKSPITVATLKASVLPMVTVTGIELSPPVTFRLRAGSGPVFLSGQECYETSDMAWEDDEEEEEEEEEDEDEDEDADLSLEEIPIKQVKRAAPQRPTSIAKRKKVDKEEEAAVRPSPQDKSPWKKGKSTPKPKRSTSKK
The following text describes a protein:
Function:
Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper.
Miscellaneous:
MISCELLANEOUS: The isooctane tolerance of organic-solvent tolerant strain KK-21 may result from the alteration of the expression of several genes including ICT1, due to the loss of their proper regulation.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MWTNTFKWCSKTEKETTTADAKVCASVQGLKALQQQIMDSTTVRGSVNNTMTPGGINQWHFHNKRANKVCTPTVLIHGYAASSMAFYRTFENLSDNIKDLYAIDLPANGASEAPALQVNKTKKIKSLRFKHIEDDVVIPVIEKRPPAEDIKSHLEQYESYFVDRIEQWRKDNKLRKINVVGHSFGGYISFKYALKYPDSIEKLCLISPLGVENSIHAITHKWEPNTTYPLTFTDPSSRYYTRKLNVPRFIFENQLNVLKWMGPIGSKLCSNYISTAYVKVPDQIYKDYLLHSFVGKNQTVQPQTIKVFTHLFERNLIARDPIINNVRFLNPATPVMFMYGEHDWMDKYAGYLTTESMLKNKAKASYVEVPDAGHNLFLDNPQHFASSLVSFLSK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASVRKLFILVTFGAFSWLLLLFQLFGFFNFPLKLHHADGLAIGEHRWSSSVWSILHLASAVISGILAKRHYNYLFGGLMLTDAMNNYFKYVIGLLTIFVTVADSWFEVETHRSIWLRYRALATRNGTILGLIGRDELARVLLRYFFAILTIVAVCALVEFTIYNQLTPGTQWHWFWLHNFYPYTFSHVRHVFHLLHISLMASNLRQLQRKLVALHQTGERERLEEYRALYGELWQINEGINELFGFSQACNIASSFAQMAFDLYWVYAMWQKQQRGVELQIFCFVPTPVIIGFLMHAAKKHQLEMDAVQGTVLDMNFGLDAEMVKLRFYFLHQLLRNRIKLTAKDIFDYDYTLIRTLVIVILTYVIIFIEIAD
The following text describes a protein:
Function:
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway that acts upstream of HRD3 and USA1.
Miscellaneous:
MISCELLANEOUS: Present with 1990 molecules/cell in log phase SD medium.
Sequence:
MSQSRWSIVLIFALFIFGSTGVNAFFNFGHHQQQQQQQQQSYEDQVLNNPCDGYLCPDTLTCVAQQKDCPCPFPKSQLKCVLPDNKFVCISKPATHNEKFRAIYDDPVKGPKAKNKGFRDCGWVSDAYKNH
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MKLLKPSWVTHDGKPIFSIDIHPDGSRFATGGQACVNCVRWSSDGRYLASGGDDKLIMIWQTGRYMCGHTTGPHWRYGHVVNIEQFRCVATLRTHTGDILDLAWSPQDAWLATCSIDNTIIVWNAQKFPEIISILKGHTGLVKGVTWDPVGKYLATQSDDKSLRVWRTVDWQQEAMVTKPFDECGGTTHVLRLAWSPDGQYIVSAHAMNNSGPTAQIIERQGFKTSMDFVGHRKAITVVRFNPNIFQKVVNKASGKSQQFSCCAIGSRDRSLSIWLTALKRPLVVVHDMFQNSVMDISWTPLTSSRGKSGFELLVCSWDGTAAYVEFTPEELGTPLTQDEMNSLHQRIYGKSMAISTQHTVNNTIIENPAMLKLQQQHTEHREKLAANKQVNGTPTKIKNPMLTSPTEKPNPKAQQIETRTPDGRRRITPLCIAPQVDFGDIPRPFMSSSLPMSSTGVAQSGLESAGTPRTSEPSQSSPSSQHATVKPLAQSMLTSVPASIPANIQPMKALDSRFTEKSKATSGTKAQSKPDKITPTTISTARQKDSDRPPVQDASAPGPTLIAKRKLDGLSQPGTKRMRKDKPALMAPAAPTQVTPTIPQDTITRSAPQPVMLRSPPAEKNISLQVGGEEETMVLELENNIQTAGVKLAGLKCRRGGKVEWETVLGTRGTLLAGSRKVLCVSCEDRSLCVLSPMCVYVYCTGRCCVSPVRIDPCVYYLPCVSIYVYCTGRCCVSPVRTDPCVYYLPCVSMCTVQDGAVCLLCSISLCVLSPMCVYVYCTGRMLCVSCDDRSLCVLSPSGRRLLPGLVLSHPTAILHCNGYHVMAVTTVGNLTVWNVQIAKVVIKNESLLPIMSGDVVIKTSSVTEQGVPVFSLSNGKVYTFSVSLGTWSTLSDVHSSLQQCSDHQAIMSSLNTSAQVKGPLASLQGQGQRSVNSLYSPDCYYGLEAQLREICDDLLGPVTTQGRLAKGSLWEPEVLGVCKRLLLGEVLQEVGSNLRLQRLYTEYQEQLDMVQTPGQ