lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Contributes to growth on fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MSASKMAMSNLEKILELVPLSPTSFVTKYLPAAPVGSKGTFGGTLVSQSLLASLHTVPLNFFPTSLHSYFIKGGDPRTKITYHVQNLRNGRNFIHKQVSAYQHDKLIFTSMILFAVQRSKEHDSLQHWETIPGLQGKQPDPHRYEEATSLFQKEVLDPQKLSRYASLSDRFQDATSMSKYVDAFQYGVMEYQFPKDMFYSARHTDELDYFVKVRPPITTVEHAGDESSLHKHHPYRIPKSITPENDARYNYVAFAYLSDSYLLLTIPYFHNLPLYCHSFSVSLDHTIYFHQLPHVNNWIYLKISNPRSHWDKHLVQGKYFDTQSGRIMASVSQEGYVVYGSERDIRAKF
The following text describes a protein:
Function:
May be involved in non-photochemical quenching, a process that maintains the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage (By similarity). May play a photoprotective role in the thylakoid membrane in response to light stress (Probable).
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MAMATRAIRYQLPSPRFRAPRCESSEPIKQIQIQQRPRGGDLAENGKIVLQPRLCTLRSYGSDMVIAKKDGGDGGGGGSDVELASPFFETLTDYIESSKKSQDFETISGRLAMIVFAVTVTEEIVTGNSLFKKLDVEGLSEAIGAGLAAMGCAAMFAWLTISRNRVGRIFTVSCNSFIDSLVDQIVDGLFYDTKPSDWSDDL
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
EQQDVGPRAWRYGISATSDFCIFLLQKLERSFTYLQSLVNGVSEKEAHDALNAAVCKGAQAHDDISSGFLYGILVDGTNAARYYRDVTFTVRDGLQHLINTLSVLILEKYTKLLDTCRAQLIWLIKELIKNSVPGVDNLCQSLLRQIAGGDVSPKNIWLAEAMLDIFLENSTWLAGLPVLIATAVYTFLRLIVDHGGQLFATLRQREVDFCISMLRDKFTECAMIGRDLIRLLQNVARIPEFDKLWRDLLNSPSTLSPTFTGVQQLLTQRTSRRFLQCRLTPDMERKINFLTSQVKFGNQKRYQDWFQKQYLSTPESQSLRCDLIRFICGVIHPSNELLCSDIIPRWAVIGWLLTTCTSNVAASNAKLALFYDWLFFSPDRDNIMNIEPAILVMYHSMRPHPAITATLLDFLCRIMSNFCKSLAAQVKVGIYTSLRQILEKRVLASLSPLFDNPKLDKELRAMIREQFTEFCSPVEGKVEDTVPMPPGSMILDGNHNSVMNCENEAQFSEDEDDIPLGKLRSKDIKFQPIREPSKAEQMDISEHLNQLGGEIRKKILELQNEKNSEVQCEIVEGLLQEVLREDFDQDTATSIGTCLAQILDNEFTRKLFPQELDDESIEESIGTPLFVIFRNLCQTPEEDPSRQAQLMLLWELGQHQPRLGYRLLYFLRASFPGGTGGGSGSGSGNGQPSYTSYRDYARSHHALNSCLLQDLRLCQEDDVRLFCYLVPEIYTQFPNVAIGNADILNLIVSCIDALQARHYLVCHILQGNMVMFRKDSFISILNASLEWETFEQFCLWQLIAAHNIPVDYVLPILPKLEFQAHAEALTSILLLLKQEKPSAELLRHILCRDVKGSDLFVVSILKYWTQEHEVQLSELVGALFVKAGSAAKRKR
The following text describes a protein:
Function:
Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system (By similarity). May serve as a key control point at which color variation is determined. Major determinant of eye color (Probable). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis.
Subcellular Localization:
Melanosome membrane; Multi-pass membrane protein.
Sequence:
MRLENKDIRLASAVLEVELHQTSALSVPTCPDPGRLLTVKPATSNYKLGQADPCIPYAGEAAGKSVCVPEHTEFGSFLVKGSSSLKDLSFKEDTPLLWNSSQKKRSQLMPVHHPEFIATEGSWENGLTAWEQKCMLGKEVADLSALASSEKRDLAGSVHLRAQVSKLGCCVRWIKITGLFVFVVLCSILFSLYPDQGKFWQLLAVSPLENYSVNLSGHADSMILQLDLAGALMAGGPSGSGKEEHVVVVVTQTDAAGNRRRRPQQLTYNWTVLLNPRSEHVVVSRTFEIVSREAVSISIQASLQQTRLVPLLLAHQFLGASVEAQVASAVAILAGVYTLIIFEIVHRTLAAMLGALAALAALAVVGDRPSLTHVVEWIDFETLALLFGMMILVAVFSETGFFDYCAVKAYQLSRGRVWAMIFMLCLMAAILSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFLGICLVLLVSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRGLLLEKVLALEHLLAQRLHTFHRQISQEDKNWETNIQELQRKHRISDRSLLVKCLTVLGFVISMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALTHLHLVEYVGEQTALLIKMVPEDQRFAAAIVLIVWVSALASSLIDNIPFTATMIPVLLNLSQDPEISLPALPLMYALALGACLGGNGTLIGASTNVVCAGIAEKHGYGFSFMEFFRLGFPVMLMSCTIGMCYLLIAHIVVGWN
The following text describes a protein:
Function:
Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Not required for mitochondrial and plastid Fe-S enzymes. Probably involved in the export of cyclic pyranopterin monophosphate (cPMP) from mitochondria into the cytosol. Mediates glutathione-dependent resistance to heavy metals such as cadmium and lead, as well as their transport from roots to leaves. Regulates nonprotein thiols (NPSH) and the cellular level of glutathione (GSH).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSRGSRFVRAPGLLLCRVNLQPQPKIPSFSYSLRSDYRLHNGFSNYIRRNSIRTSPVINAFLSDNSPSPSPSPSPIRFVQRSSMLNGRLFSTSTPNPDQTTTKTKEIKTTSSDSDSAMADMKILRTLAGYLWMRDNPEFRFRVIAALGFLVGAKVLNVQVPFLFKLAVDWLASATGTGASLTTFAATNPTLLTVFATPAAVLIGYGIARTGSSAFNELRTAVFSKVALRTIRSVSRKVFSHLHDLDLRYHLSRETGGLNRIIDRGSRAINFILSAMVFNVVPTILEISMVSGILAYKFGAAFAWITSLSVGSYIVFTLAVTQWRTKFRKAMNKADNDASTRAIDSLINYETVKYFNNEGYEAEKYDQFLKKYEDAALQTQRSLAFLNFGQSIIFSTALSTAMVLCSQGIMNGQMTVGDLVMVNGLLFQLSLPLNFLGSVYRETIQSLVDMKSMFQLLEEKSDITNTSDAKPLVLKGGNIEFENVHFSYLPERKILDGISFVVPAGKSVAIVGTSGSGKSTILRMLFRFFDTDSGNIRIDGQDIKEVRLDSLRSSIGVVPQDTVLFNDTIFHNIHYGRLSATEEEVYEAARRAAIHETISNFPDKYSTIVGERGLKLSGGEKQRVALARTFLKSPAILLCDEATSALDSTTEAEILNALKALASNRTSIFIAHRLTTAMQCDEIVVLENGKVVEQGPHDELLGKSGRYAQLWTQQNSSVDMLDAAIKLE
The following text describes a protein:
Function:
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Sequence:
MNEKHPGPLVVSGKLSDGERMKSESNFLRGTIAEDLNNGLTGGFSGDNFLLIRFHGMYQQDDRDIRAERAEQKLEPRHAMMLRCRLPGGIITPQQWLGIDKFAADNTLYGSIRITNRQTFQFHGILKGNVKPAHQLLNELGLDALATANDVNRNVLCTSNPVESALHQEAYEWAKKISEHLLPRTRAYAEIWLDAEKVATTDEEPILGATYLPRKFKTTVVIPPQNDVDLHANDLNFVAVADKGKLIGFNVLVGGGLSIAHGDKNTYPRKASEFGYIPLKHTLAIAEAVVTTQRDWGNRTDRKNAKTKYTLERVGVETFKAEVEKRAGVSFSAIKPYQFIGRGDRIGWVKGVDKKWHLTLFVENGRLLDYPGRSLKTGVAEIAKIHQGDFRLTANQNLIVAGVPEKDKARIEALAREHGLMDDNVTSQRENSMACVSFPTCPLAMAEAERFLPEFVTRVEGILQQHGLADEHIVLRVTGCPNGCGRALLAEVGLVGKAVGRYNLHLGGNREGTRIPRMYRENITADEILLITDQLVGRWAKERHVDEGFGDFVIRAGVIAPVIDSARDFYDVQEAM
The following text describes a protein:
Function:
Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Binds directly to microtubules; but with a much lower affinity than SKA1 (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
METVDKLEAMFQKAEADIEYVEKRLKFDFMASAREAGTFEGNPVELLEDLSAIKARHAALCAQVEEIAAEQKRSMDSIRAHLDTTVQLVQQLQNTADVQVPPLTEEEQEARDALCSSVAALNVEAMPTSEPQSQAQSEAQNVHEDVSEKTFETVPRSVRGNLKLKDLNALYKQLFEHFSDKSRGPISTQRMKKLNMKVNDSALKTLQHLKLIELDKKGLVSLLAND
The following text describes a protein:
Function:
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MRINTNINSMRTQEYMRQNQDKMNTAMNRLSSGKSINSAADDAAGLAIATRMRAKEGGLNVGARNTQDAMSALRTGDAALGSISNILLRMRDLATQASNGTNNTEDTASLNKEYEALKSEIDHIANKTSFNGIKFLSTDKGGAADIKVQLSDASGDTMTIDSLDAKKITTANLTTLADRGTAETEIKALDTAIQELADARATFGSQLNRLDHNLNNVTSQATNMAAAASQIEDADMAKEMSEMTKVQNP
The following text describes a protein:
Function:
Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Active form which is able to induce an antiviral response and prevent hepatitis C virus (HCV) replication in cell cultures; MISCELLANEOUS: [Isoform 2]: Inactive form; MISCELLANEOUS: [Isoform 3]: Inactive form unable to elicit an antiviral response; MISCELLANEOUS: [Isoform 4]: Inactive form unable to elicit an antiviral response.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MRPSVWAAVAAGLWVLCTVIAAAPRRCLLSHYRSLEPRTLAAAKALRDRYEEEALSWGQRNCSFRPRRDPPRPSSCARLRHVARGIADAQAVLSGLHRSELLPGAGPILELLAAAGRDVAACLELARPGSSRKVPGAQKRRHKPRRADSPRCRKASVVFNLLRLLTWELRLAAHSGPCL
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MFSLDAPLAPAIDAFVDPENDDDAQKTGLNTVVMQVHRHVSMEALIQALGAFLTSGDDKVRSRATLLLAEVLTRLPELQLTPSAVQLLLTFFADRLADFPSASACLRALLALETHHAAQVSSPRTTVALILKLGSSLHIPQLGQAMRKMCFDLMQLALAQSTVVELLLDSVPASKDAQDASVDDAEQSEDLGQKFAQTFLGAMEGEKDPRNLLLCMQVARTLLSKLEPVFSRSDALLQQYFDIVSCYFPIIFTPPPNDPYGITSEGLILSLRHAFAASDLLAPLVLPFLLKKLASTVVEAKLDALQTLVFCGERYSVNALLLQMHAVATALYDEVLDGEKQEVIAEARQAISRFSGVVARAKAQDTPGAAYAWSKFVVEMTARAAGELRENAADSMVSVSAGQVLAALGHDSSMSFGHVLKIAVPLLVEQLHNESSGSNSVASKCEAALARILLLVDTIDQEIDHSGQAQPMRPHTPALIDALVNFLSSDQDNQASHGSSPTARCVAVQALCHLLTYPPSPIVAPAQVKALINLFTRMLLLDPTAEVRTACLQSLKEISTVSTSSVPSMGSGEGPATSGYAAFVVEISLARLMAAVNEGSDHEDEDDGEGSGVAAVLAASNRNFDSFFEEALLAITELCRESSIFQATIFLLIDLCVERNANQQGGIAFCEADGDVTRQRHVDCLLDAVAKIVEINAGDRTSMEFCVQESSSASIVFRLLTAVETSAARATASASGLVDDAKLAACVRIFRAVMQNVSPATQQRLVDAVVPAFLRTHPSEPASLQLVPLFAAVINSATRDVALPETSLVINRLLDLAQSGAVSVPETSPQRLQIVYADAALSAAKSLASIVNKMSDGAEFDALIDLLLSQKLAAVISNSTESFTVRVAALQIYAWIAKALVIRGHKDHAPMCLRFLCNFLTPGSQIDDGDERMEQAGGEQEAAALRMEVAKTFKLLVSEYPDVLNRKCGAFITFLYRQRMFDMMFPVLLEFIRTHIGEETSVAALVAFAQVIAHSPKAVYMPHLAQIFPLMVQALNTDDCELGSAAIQTFKPLLLESVESAKPFLKDVFPGLLKQAQFGPGAKDRYAALECLAKLATIPYELVHPYKDIVLRKLLLVLDDRKRLVRHMAVRVRNQWSIL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSNPLNVKISLQPLSETKIQEIAYNGRETFIPPLSMSESLTDLANRINFLAEDESDVDQDVERKLTPGKQWPWENIRSHLQSALIEMNVLVDVMAIAQNKRYLMFSSVAKEAETPKPMLQMITKKRCLGAAGKILLDGAERLNKARNEVSTQQNFHAQLLKLRQRWRVRRHGDKILGDLSYRTAGSDFLHHGSFEVVKVSADDMDHDVGNENLPLRVVMSPDLKGRSTISVMIIDTSGTDYITDMASLNYNDEVGFNTSSMHDPSWHKKLCQAQNVLYCKELFAHLTKEAVQYKNVGAIAPIVVIKDTISTEIFPSIRLVVKLIHSMDTDNQQSQTENPSALETVFSLKFTLLQLLQEVHRRKLEISPPRPTSAVLGLTPHMRRAAVQGNTLKQLTLASDKNNISFIESLLKMAKHHVVRKRVVSLIQTVTKSFQDPDVQAHWSTIGNMFESSVRILIASSGFESCYRTVVQLTLYSDHIKALQREGRVLTLSTEYSDLYLYFITLISSHQLQTVQALSKILNWSLLHMAPHAGVCINNSVINRGTMLLASPSNDSKLSLSITHNTDHSISHNVRIQFSKSLDLKLNNQVFTETQDNLTLSSKYLGLGGEWKIVNWQNLHGRHFVQKMETLLTSLVSN
The following text describes a protein:
Function:
Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MFIPNDRPSVLQLPKHEKDSTAADIKSIVANRDRRLIAVATNDAIYIWLANPQLLLCSVGVIDANFKETRGELKEIYWKPDSTSIAVTTNQCKILIYNLDLRDDEQCYNFTDSADPYFQRNSPELFIKGSRPTAHLHPTIIINLADIPTCCVPSRDEFLVCLQNGFTHHVTWTGEIIASLSFRASSIPFSVDQLQSKSENITSKSTYIFDAVYAPLLGGFAIVLSDGQGALLTSNDPNFAPNAILGVWAPNMKDATCCDVNHKFLLILFGCKNGDVCAYNIDELNGSLVQSFRVAPKVTNGPDLTNRLGPVHRITALANGYGFGAIWSPLSGAHALPRLVAVFTSFGAQSFCNLEGVVEEDQNDRYTAIEWGPEGFQLWLGTENELMMQPFVRSASCSSPAMEHCDRAVLMSDSQVLISAARDREAEACAPHSVWDHITVTHEYLSSNWPLRYASTDRNYKHLVVAGDQGMAYCSLSNRRWKIFGNETQEKNLLVTGGVFIWNDDVIGVVGVAADTDKSHLSFYPISQRLDSRYASVVDLEHKSVMSVLRDDVCAVFDISAQITLYKLTAHLETGRDAFTKVSTEIVTVIRINEIVPHPTCIVSLQMTQLNLDVRGKLSPAFYSSIDTVLVNISGRLITLSVNEDGKLHQPMVIASYVEKMWHDRCQVSQSTQSQNQDLPWKNHRRNGSNVSIQSVSTSTTSEPSSPMNQSCSSHLSNALWIACGAKGIKVWMPLVPGKRNLATQEMTFIAKRIMLPFELDIYPIVISAKDCLAMGVESQLQHVARASRNQGQMESITMYGLHRNSEVFVHHLLRQLLKRNLGVFALELAGACRSLPHFTHALELLLHGVLEEEATSSEPIPDPLLPRCVAFIHEFPEFLKTVAHCARKTELALWRTLFDVTGSPNALFEECLQLKQLENAASFVIVLQNLETTEVSMDQAARLVKEALEEKKWTIAKEMVRFARSIGSEDIDAFFRTPPPSAKTSLSRRPTVSSPSADSSTEFVINRFQAGAAGGRLNKVRHSQSTEQKDAPRKDSIGGSSKDKMALSWGLSGELSPQLATNRLAAKMTSILEDHAWHLLNNYWLLDLGFFWSELQFDLLGLLETRRKQISLSPKTTNENCFLIEDFALALTRLHAQFSWPYPLIGSQFVHQIEKKLGNIRVSQSTASLNGLLNDSLDNIKKPKARKLERTVVDLNGARSRIRETDIEASEEDVEIQEAVLERVRGSAVELAPVIDRSPSTSSSMNHHAPLAPPSPSSCDSRSLAGDCYQNTDFLVGEKSSRGNLQSSHQLELLLSLFSQTATIDWIFLFCLLSRDERKLRQEINVSMVRRAGEKSFARVRFACSELSRWAVEKCCGYVALLQAFDAHLAVVAEQAGCADLKFSPDNENRKASQKTSADDPKRGRRRADSGSSKLNNSFSNPKLNGMNGGRRERSRSADRAHKSVKRYDDVVCAEDALEKANEEGCSIM
The following text describes a protein:
Function:
Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. Also activates expression of hyf operon (encodes the silent hydrogenase-4 gene cluster).
Sequence:
MSYTPMSDLGQQGLFDITRTLLQQPDLASLCEALSQLVKRSALADNAAIVLWQAQTQRASYYASREKDTPIKYEDETVLAHGPVRSILSRPDTLHCSYEEFCETWPQLDAGGLYPKFGHYCLMPLAAEGHIFGGCEFIRYDDRPWSEKEFNRLQTFTQIVSVVTEQIQSRVVNNVDYELLCRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYSTHYLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLHERDDLAPYERMLFDTWGNQIQTLCLLPLMSGDTMLGVLKLAQCEEKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERLVDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQSDSTVLILGETGTGKELIARAIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGASAQRIGRFELADKSSLFLDEVGDMPLELQPKLLRVLQEQEFERLGSNKIIQTDVRLIAATNRDLKKMVADREFRSDLYYRLNVFPIHLPPLRERPEDIPLLAKAFTFKIARRLGRNIDSIPAETLRTLSNMEWPGNVRELENVIERAVLLTRGNVLQLSLPDIVLPEPETPPAATVVALEGEDEYQLIVRVLKETNGVVAGPKGAAQRLGLKRTTLLSRMKRLGIDKSALI
The following text describes a protein:
Function:
Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MASEDLNIVAESKKGEENVIVDNSKDMNRPENLDLSTEKTDTANENGPKDEASKLVKEADLPESGTSVKSKTAKDNKPVKRKSGTFSRSPRFMSQSSSFPTKGAYTDITRKSIDATTSKTSLKPVVAGGSKPKATPSSSSGVSAKRTSLVSAPLKKQTMPVKTISKDAASGPTSKLGDEGSKSIKEETAGKDVEEAGSTTAVVADKVSNPLKAEMASKDDEDTRSTTTSTSTPRGRRSSVGSASGFSFRLEERAEKRKEFYMKLEEKIHAKEVEKTNLQAKSKESQEEEIKRLRKSLTFKAGPMPSFYKEPPPKVELKKIPTTRPKSPKLGRRKSSSDATGGEAAPRVTKPKDSSSSTVKKPITKSQPKLETQEKSVKAKEKKKKVKKEEAEKRGEEEKATAVAAKPEEQKPNSNNIQVKAEIMASEVVVGG
The following text describes a protein:
Function:
Probable phosphatase which regulates axon regeneration after injury by linking the svh-2 and integrin signaling pathways; [Isoform e]: Not involved in axon regeneration after injury.
Subcellular Localization:
Cell projection, axon. Note=Localizes to punctate structures along the axon in motor neurons.
Sequence:
MAAAALCCASRKSNKYNNEAGYEVYTISEDQLRLKQKMKDRKEGVQVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDISSSLDAIPFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIAVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERFLGPDGPPSYKRYLGYFSSLLSGRISVNSDPLYLHNIILTFFEPINVFLKIYERLVPVYQSKTVALNKSSKFEMDGSLKLRGDIFFKCIVAASSPGSSTRCLFTCQLNTCALELHPINSEGYSVVRLHKEELDLIFNDKKIDNRVTVELVVSHTSGPTTIATAAVQSVHSLLPRNNSYETFELAQDDETNRSRLEVEYSEIRKKSTKSSKSANPINNNQEEEMPVGPPVPPKPSTPIMNGERLGEYGVGGHIGNGDVVPERRGILPASLREKINQKKELEGRATPSIEPDLVGRDRYDKASRCFSYVPAKSMQEAFERPRRTSFSRAIEKRENSVENVSQEEVARTEIPQSYQQNDISTPAKWDEQVEDAKQSALLEELARAPSAMQHNYWGNGEVDNVQVVDQAQRAVITPTSTLQRRPKPPARSGSYRTLNDDAYCSDMDELCDPEYYLNYNSNTAPLPPPRRQEQHAGTRSVQLPRKKMNFDAVTDPLDDVLESTKRLGSAYSVGDVRGGQQQQQEQHNASNDFNFSNTLNNTPTDYRQHYRNRNCQSVTTPRNHHFSTPSREQEADAADTWLSGKLKKVRSKRDIDPDIVRRRTQEKMLLEELKDSAANNDENQHNLPNGHARGAGLQNIDPLAEFRREEERLRNTRSPYGEERWRGRMRGKPPTPPPRESSASPVNSLPRGTPAHHMDRQRHNQSVPLPMHHRQFDEDFDVNSLFNFSHDPRQQSTTLERGGRSLSRGARIQDAYYASQQDLSANNRFNSGQERVAAAIYRAETAHRDMYASGTINRAETPGRYFPENSAVLERSSTPSFPVSRATPLPFHPLLYNNGERGGSGHAAGGGGGGHNGYSTMNNRSASPRLFGGSSTLSRRSSVNSVDTSEIIHHHPLFVKDTSKYWYKPTISREQAINMLRDKPPGTFVVRDSNSFPGAFGLALKVSTPPPGVNPGDGSELVRHFLIEPSPKGVKLKGCNNEPVFGSLSALVYQHSITALALPTKLVLPDFDPAATPEHLSATQALLEQGAACNVVYVGSVDVESLTGNECVKRSIATCSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFRRHFNVQSVIFAGMDPIERRFENTRALGFHDGCIAQARLFAFVARIPSSSENACHVFAELEPEQPGSAVVNFINKVMLAQKNRS
The following text describes a protein:
Function:
Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The RING-type zinc finger domain may be essential for ubiquitin ligase activity.
Sequence:
MSVRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFTSIKELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLCVFAFLSAACIFMLWTRHLVMVYMFLTSLGLTFLSYWSNVSALALTERSPSMVEDLMSLNTTRLLDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPAKVVQHLPVVAVFTPIILTKITLMQSAMEASRTVYNGYQYAMNFVSNFGLSALIENEWQRLNVPNVLRVFWTIRLIQGGYALATTESDEPLDLMTATQKLLVDGCETMTAVLGMTGVISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADENAPEAEPAPAAQAEQPMRIYPRDDANNAAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAVSAIVESAAAVGEARSLVSVASSSSATHRISASGSSDSSYMTASAQSPPPTATSAAAVATAAASNTTHMFRMSQDQQ
The following text describes a protein:
Function:
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Sequence:
MRKTVLRPNEEHFVVLEPKDVARASFDVIDLINKLGEDSSRTQGLKHIITTYSSFSNSDNNRLYILYDDGNTRPVGFIKTGYKHLYIFDVYGFQHEMTPLCLLDFFVCNDVQRRGYGKKMYDYMLKCENVEPQQIAIDRPSPLCLSFMKKHFGLSEYVPQTNNFVVFNQYFETKETPSYPKPNISMTPQKPKYHPVDFSTLNQNNNRVSTPQKQRYNPITWEPM
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.
Sequence:
MTGTVVELAPGIHAGFTGRAGGVSGEPYATLNLGDHVGDDPAAVAENRRRAALGFGISPDRVVWMNQVHGATAVTVTGSGQAGDVDAVVTPEAGLALAVLVADCLPLLVADAAAGVIGAAHAGRPGMAAGVVPALVAEMARHGARPERCVALLGPAICGRCYEVPRDLQDRVARTVPEARCTTAEGTPGLDIRAGVTAQLTNLGVTNITHDSRCTRESADLFSYRRDATTGRFAGYVWRVP
The following text describes a protein:
Function:
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MSSFPKCPNPPFCSCSLTDSVAMERSGSVLLLLLHVLLGSGGAQHLSGARLGPWRHRLQWENNGRVFSLLSTGTRYHSPSHSRRRTQLLLTTNPGSEQIQPPAALGRSTRTRPVGSGGAAGILEQISQTEASDVGSDAGQFLLASGRTSTRLAPFNGSDGAFTATPEFSGSGVPRGGRSAPRGDAGAQRANAAQERARGSERSQLSGLEGDGSNSVWSNVSAEDSVPHQTHSGDAPTAHSARGARPPARVAPQPNDTPPEPPSNNAGTRLPPRATDTADASDPRDPHSIHYRNSVFYNVYAPDRRNRLDTRPPGTGYGTRFFHNGLPDLIPDPYYIQAASYIQRVQMYALRCAAEENCLSRSAYHHSVSDLDYRVLLRFPQRVKNQGTADFLPQKPRHQWEWHSCHQHYHSMEAFSNYDLLDVSSGQKVAEGHKASFCLEDTSCDPGVRRRFACTAHTQGLGPGCYDTYHANIDCQWIDITDVPPGNYVLKVTVNPSQLVQESDFSNNEVRCDITYTGSHVQARGCRIVV
The following text describes a protein:
Function:
Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Sequence:
MLIKEYRMVLPLTVEEYQIAQLYMVAKKSKESTKGGEGIEIIKNEPFDNEKGKGQYTEKIIYLANSLPRFAAAILPSSALKIEEKAWNAYPYCKTEYSCPFFGEKLVLSIESMHLPGRGEVENALKCDAETLKQRHVDFIDIANDQPKEYIKEEDPKIFKSVKTERGPLDDPKWRDKVEPVMTCYKLVHAEFKYWGFQTKVENVIQDTGVRDVLLKAHRALFCWIDEWFGLTIEDIRKIEEETKAELAKKLEENKAANK
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein. The carboxylated form binds strongly to apatite and calcium (By similarity).
Subcellular Localization:
Secreted.
Sequence:
AGTAXGDLTPFQLESLREVCEVNLACEHMADTXGIVAAYTAYYGY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MGISQKKYIVNNIIDDNKKSVIIHKYYRESLFENKLRFECELEFLQSLCNIDYIKHLYENKYFNDYNFINYLKYLNYWRNKPYIFYVHFPICLYVLDILNNNNTNIYFNHANSFQNFIYYLKLHWLYFSYQI
The following text describes a protein:
Function:
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities (By similarity).
Subcellular Localization:
Secreted. Host cell. Membrane; Single-pass membrane protein. Note=Secreted, and delivered into the host cell.
Sequence:
MEPIHNPPPQTCSYSRPSTTYTSFKDASCDTKVTRIIIALFLIVISCGLILCAYTFRDLLDADYLAQEGPQQATKLLQQLDDVLTGPPLPIWDNEHLFQFSCLMQNKHRRVLPIDICNPLTKFNFLECICNCLMTKQSVNVNETDMCELFCPPTCTPENYRRLLCTSSVFPFVMWHDPSADTQEAMLTKMDQTMSSGRVGNSHWVLVIVDIEYRCVTFFDSLCDYVASPQQMREQLEGLAVSLGAIYPKEGGADSDQEELLSPFQVRIGSTVKVQSPGEFTCGAWCCQFLAWYLENPDFDLEEKVPTNPSERRALLADFISTTEQAMSRYSSLSWPTTD