lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in starvation-induced autophagy. Involved in mitophagy. Functions with ATG17 and ATG29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. May be involved in microtubule function, such as chromosome segregation and karyogamy.
Miscellaneous:
MISCELLANEOUS: Present with 486 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton. Preautophagosomal structure.
Sequence:
MNVTVTVYDKNVKYRLEENIKNNKGPSNDDQPAYNNESKSTDGSDYAMFPTNIKYIFEDNNDELVDSSDAALTAGIDKVGDELENVIIVQLDESGSLEDITLISDQYELLSHRTNSLSLEENQMRTLSSHGDDKSNDEEEELSVDSDRFRVDSDIELDVISQFCDLSPFLRDLSLNDLIKLYVTQNEQLQMLSNSV
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGGRNQTRSTREKPLIRQVWASNFDSEIARFDECLRFHTILTIDTEFPGFIAQSPRGSIDDELYKDFCFNVNQTKLIQLGITASDDLGQIGGSWEFNFSDFDFEADAHSPYAIPFLEHNGLDLKKMKKDGIPIASFTKKFLPILRKRDIFRWVTFHGLYDIGYLIKAMGLITVLPKSMEEFATVVVNEVGIVRDLKHMAKFCEGLDDHGRLGLERLGKLLNLKRFGMKHNAGSDSLLTASAHLEMVERFGMNSKVCNGFLYGFSETLESMKMKMKMKICHHNILRFSLYIPCYFVFYMST
The following text describes a protein:
Function:
Endo-1,4-mannanase that catalyzes the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans and heteromannans. It is a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans. Active against locust bean gum and gum guar. Also has transglycosylation activity. Produces mainly mannopentaose and mannohexaose out of mannotetraose.
Subcellular Localization:
Secreted.
Sequence:
MIFSTLLSLALLATTATARKGFVTTKGDKFQLDGKDFYFAGSNAYYFPFNNNQTDVELGLSAAKKAGLLVFRTWGFNDKNVTYIEDGLPQYGGEGAGTTEVVFQWWQNGTSTIDLEPFDKVVNAAAKTGIKLIVTLVNNWADYGGMDVYTVNLGGQYHDDFYRLPQIKKAYKRYVKEMVTRYRNSPAIMAWELANEPRCGADGVRNLPASDECTPELLTSWIDEMSTYVKRLDPHHLVTWGGEGGFNYDSDDWAYNGSDGGDFEAELKLKNIDFGVFHSYPDWWSKTVEWTNKWIVDHARAARRVGKPVVHEEYGWLTPQGRLDNLGTVSNITRLEAVGGWQSISLREKMSDMFWQFGYSGYSYGRNHDDGFTIYLDDAEAQELVYKHAKEVNKLNRRR
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAFGNIQELDGEILKNVWANYIGTPQTDTRSIQVPEVSRTWEALPTLDDIPEGSREMLQSLDMSTEDQEWTEILDAIASFPNKTNHDPLTNPTIDSCSLSSRVSCKTRKYRGVRKRPWGKFAAEIRDSTRNGVRVWLGTFQTAEEAAMAYDKAAVRIRGTQKAHTNFQLETVIKAMEMDCNPNYYRMNNSNTSDPLRSSRKIGLRTGKEAVKAYDEVVDGMVENHCALSYCSTKEHSETRGLRGSEETWFDLRKRRRSNEDSMCQEVEMQKTVTGEETVCDVFGLFEFEDLGSDYLETLLSSF
The following text describes a protein:
Function:
Forms a cluster with L17 and L22, and with L22, a pair of 'tweezers' that hold together all the domains of the 23S rRNA. Interacts with the antibiotic troleandomycin which blocks the peptide exit tunnel.
Sequence:
MAKHPVPKKKTSKSKRDMRRSHHALTAPNLTECPQCHGKKLSHHICPNCGYYDGRQVLAV
The following text describes a protein:
Function:
Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
SRDMKDTARSPSINEFSRPVAVTDFSLLVEKLSQNKNKGFSSEFDDIRGIPYAGTTSVAEKACNKTKNRTAKLVPFDHCRVKIEGIPAVEGSNYINASYVPGPHSPEQYVATQTPLDHTKKDFWRLIWETGSNTIVMLCNVMEGGKKRCSEYWPKKQTEYFGNLAIQMTKQDVCKDWIVRHFSVTMRDKVRHVTQFQFMNWSVVEQGNPLPLVRFIKSYRTTRHNEYKPTIVMCSNGSGRSGVFIGLDKIVDTMTSYIDVFGTVASLRKYRPFMVQTLTEYIVMHQCIVNFIDDVTIEQPTGDGLEETIF
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MSNKENRLASNSMTPTRKPSESFGKNNGTSRSGSAKQPSKQMTLMSFLTPKPSTASVHTPIVEPSKPLFLAELTESDHQSCSTHQFTSEKPKAWPPRAVSSVSLASQSSNSSVLDHLSSVSPLHSKTQNLIGSQLLGSHNSICQSDTASNELSDTLMPSKLNAENASSVTSPLSNSLGLKRPRSGSAANSYIEQDSDEDIPLLKLRAKNRQTIIEKDDDDYSDTPSCMLNPNEMTKSKVASSPINLQAYTPTKSCSSTPKNSDTTTRRDMSPSLSNTTPSPSRHGSRLASLTNSDRKKERIAQFKDKNELRYSWLQDIKDANKNAPDDPNYDPRTLYIPPSAWANFTPFEKQFWEIKAAHWDTVVFFKKGKFYELYEKDADIGHQKFDLKRTDRVNMRMVGVPESSFDHWAAQFIAKGFKVAKVEQMENSIGKAIRDRESSKKEDKIIRRELTSVLTAGTLVDAGLLTNDLNTYCMAIKEEVSAEHLPPTFGICFVDTASAEFNICTFEDDVDRTKFTTLIMQVKPTELVLEKGMLSKATMRILKNSLENPIFNFLLRDKEFWDEEVTMDELNRGGYFKDMASTLPNESSSTVDSSWPQALRESINHSIAMSAFGGLLFYLRSLKLDTSLVSAKNFHLYDPIKSSGTLILDGQTLVNLELFENSSDGSDRGTLFKLLNQCVTPFGKRLFKLWLCHPLQSIDLLNSRLDAIDDFTSIVGLLDTVRSNISKLPDLERIVARIHTKSCHIKDFILALAAFDRVFTVMTECQSYIGKLQSALLKPLFSEILNPELMELIQYFKVAFNHQDAFDEGKIRLHSGYDDVFDSADKNVVAIEKKLDVYRRECEKKLSYNGITFKNIGKEIFQMEIPAKIKVPSDWTVMSNTKAVNRYYTTKSREMINEMLEAQEIREEAMRQIKTRVFEKFDTQYKGCIGDNFIANDTCLGGDSGNATMILLTGPNMGGKSTLLRQTCIAVIMSQLGCYVPAAKCRLTPFDRIFTRIGASDNIMAGQSTFMVELTETSKILREATPRSLVILDELGRGTSTYDGYAIAYAVLNHLITNVRSLGLFSTHYGTLTNEFHNHPLIKMMHMSFFADQVNKQVTFLYKLEHGNCPKSYGMNVASLANVPKKIVDRAEDVAKSFEERQVCHQSSQQAHQFSLGSLITFAKLVEYAKKPSLSVTDKAILAAHLQELTRF
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTDVLFDVRNALVVGNYHQAIADGSTARALSSRPADVAAFNVEKSAVVALGQIGLGQVDAVISQLRSESNPLLVTIRTWAELICAMRDYDALSDPVTNVTQRLQSDAEKVAADAVYKAVFAATSLLYQQDVIGALTLAKKWLGELPNPEGVLARRYTVELHGVATEALLRLNRPDEAAKEVKRMEQVDSEAIVTILYSGIVSLHQAASDVHMANYNAAVSAFKEVQLRCGQSIMVSNLMALAHMGLKDYDAAERSLLDALAVRSNDEATLVNLAAVSAHKAKPLDDAERYIQQAVSMHGPWGEAYHAKERDLDEDMSAFLLEG
The following text describes a protein:
Function:
Functions in the periplasm to maintain cell envelope integrity.
Subcellular Localization:
Periplasm.
Sequence:
MRFVRIAAAASGATVFMWAGFAGAASAASAVRLVPHRAIYDLTLDRADEKSGISGLTGRMVYEFNGSACEGYTTNFRFVTRVDMDEQPQRVTDQQTTTFEDADGKDFRFVNKTFVDKELVKEVRGDAKLEDGKTVVKLSKPKENTLDLKGTQFPTRHMEELIGKAEAGQKFYQTTLFDASEDADRVVATTVVVGKQQAVPDDETKVMGKFSKDQVWPVTIAYFDDKEQQDGMPIYRINFKLYRNGITRDLTMDYGDFSMRGKLVKLDIYDTGKNKTGCSK
The following text describes a protein:
Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPAYNSVFNADPSPRLIGNFPLFPLRTKIRGPIYPLPFPDPPLAANESPDPDSESYDILDETLALFRANTFFRNFEIQGPADRLLVYGIWYISDCLGRIKPHYGVREATKEVNNAALDVNFALPGDPGWPLNQMYEPPRDRQDAEVLRQYLSQVRQELAQRLLARVYDDETEDKPSKWWLSFTKRKFMGKGL
The following text describes a protein:
Function:
Catalyzes the demethylation of isoprenylcysteine methylesters (By similarity). May act as a negative regulator of ABA signaling.
Miscellaneous:
MISCELLANEOUS: Plants silencing ICMEL2 show enhanced ABA inhibition of seed germination.
Subcellular Localization:
Endoplasmic reticulum membrane. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MQLSPERCRPMSENREAWSANSEEMELLHGSNRLSSPEHVRRRVSGNSSEDGSPRICRQQSFGRDIGHAAAETYLITRLSFNLLGYLGVGYRWITRLLALACYAMLLMPGFLQVAYLYFFSSQVRRSIVYGGHPRNRLDLYIPPTSDGLKPVVVFVTGGAWIIGYKAWGSLLGLQLAERDIIVACLDYRNFPQGTISDMVSDAAQGISFVCNNISAFGGDPNRIYLMGQSAGAHISSCALFEQAIKESRGESISWSVSQIKAYFGLSGGYNLFNLVEHFHNRGLYRSIFLSIMEGEESFKQFSPEVRLKDLNVRKAAALLPHIILFHGSADYSIPPEASKTFTDALQAAEVKAELVMYKGKTHTDLFLQDPLRGGKDELFDHIVSMIHADDSDALRNDAVAPPRKRLVPEFLLKLAGRVSPF
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MAATPADAKTEAAKMDLLEDDDEFEEFEIDQEWDEKEEGNEAVQQWEDDWDDDDVNDDFSLQLRKELEGSNAQKS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Domain:
The zinc finger domain is required for E3 ligase activity.
Sequence:
MENGGRPSVGQVILLTTSSAITALFYSIYRHKYRSVQTLKEAKKFCLTDDLPAVLSDLPGKCVPYAVIEGAVTSVKEVLNSQYVENCKGVIQRLSLKEHKMVWNRTTHLWNDHEKIIHQRSNTVPFDLAPENPGESGVSVRVLRPLEAVDLGLETIYEKFHPAVQSFSNILGHYMTGERPKGVQETEEMLKIGATITGVGELVLDNKTIKLQPPKDGMLFYLSSMDYEGLLEKQEVQMRWWRILSIVFGVASCITLFFILRRKYRHYKEKQHLKNLQREFEESRARQRVQQEPQNKEEVQNPCSICLSTEKSCVFLECGHVCSCISCYQALPSPKKCPICRNFIDRIVPLYNS
The following text describes a protein:
Function:
Required for the female reproductive tract development and fertility.
Subcellular Localization:
Nucleus.
Sequence:
MDSDIMNMMMHQMEKLPEFCNPNSSFFSPDHNNTYPFLFNSTHYQSDHSMTNEPGFRYGSGLLTNPSSISPNTAYSSVFLDKRNNSNNNNNGTNMAAMREMIFRIAVMQPIHIDPEAVKPPKRRNVRISKDPQSVAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKKQVQSLEEQAVVTGGGGGGGGRVLIGGGGMTAASGGGGGGGVVMKGCGTVGTHQMVGNAQILR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MVAKPPVMSFHFAQDLWPEQNIKDSFQKVTLRRYGKCEYENLQLRKGCKHVDECTGHKGGHNTVNQCLTATPSKIFQCNKYVKVFDKFSNSNRYKRRHTGNKHFKCKECSKSFCVLSQLTQHRRIHTRVNSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKCEECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQASHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHKRIHAGEKPYKCKECGRAFNISSNLNKQEKIHTGGKLNKCEECDKAFNRSLKLTAHKKILMEEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPYKCKECGKAFNQSSNLTEHKKIHTAEKSYKCEECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHKKIHTGEKPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKCEECGKAFNRFSTLTKHKRIHTGEKPYKCEECGKAFNQSYQLTRHKIVHTKEKLNKCEEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFSNITNHKIIYTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGKAFNLSSTLTAHKKIHTGEKPYKCEECGKAFNQSSNLTTHKKIHTSEKPYKCEECGKSFNQFSSLNIHKIIHTGEKPYKCGDYGRAFNLSSNLTTHKKIHTGEKPYKCEYGKT
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPRSGARRVLEAQEAAAAAAAAGAGGGGSKRLSDDEDDSDAEGAGAVENGGVEAKKVKPKKPKKPKVTVAEAAAKIDAGHLNVFLADITASYESQQDIQLMRFADYFGRAFASVGSAQFPWLKIFKESPVAKLVDIPLAHISEDVYKTSVDWLSQKTPEALGSFVLWLLDSIVTDLTSHLGAVKGSKKVVQPAPSKSQVAIFAVLAMAVRRKPDALISLLSALKENPKYVGQDKLPVIVWVILQASQGDLVVGLYMWVHLLLPLLCGKSCNPQSRDLILQLVERILSSPKARPIILNGAVRKGERLIPPASLDQLMKVTFPAPSTRVKATERFESIYPTLKEVALAGSSGSKALKQIALQISNYAIKAAGEGIPDLSNEASNIFIWCLSQNSECYKHWDKLYLDNLDASVLILKKLSDDWRIHSSKQPNLDPLRETLKLFKQKNEKALAKEDDASHHALLKDADKYCKSMLGQLSKGPGCLKILMFLAILAIFAAVMFPNLQSWDWDLNKLLEKLNLPQNF
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
Sequence:
MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNVTTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAAEHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY
The following text describes a protein:
Function:
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins (By similarity). Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubqln4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
METAEGPHLVRLYVYDMSRGLARRLSPVMLGKQLEGIWHTSIIVFDEEFFYGREGITSCLPGRTMLGEPDSVMELGITEVTEEIFLEYLSSLGESGFSGESYHLFDHNCNTFSNEVAQFLTGKKIPSYITELPSEVLSTPLGQALRPLLDSVQIQPAGGNIFNRQSGPS
The following text describes a protein:
Function:
Acts as a protein folding chaperone for elongation factor 1-alpha.
Subcellular Localization:
Nucleus.
Sequence:
MSSDKTNLFPTLGEVADRTGKAESLEQEGDDRQMQEIESLCMRCHENGTTRLLLTSIPYFKEIVVSSFRCDHCGHRDTEIQSAGEIQPKGVSYTVHLLTRADLDRQIVKSNWATITIPDIQLTIPPGRGQINTVEGIIRDTVRDLNISQPVRRVMDPETGKKIDELLEKLRAAIDMEEDDEDDGGVGMDDDVKPVHHEPSNSSSKEEKPFVPFSMIVDDPSGNSYFQFKGSQSDPQWNMRAYSRTFDQNVILGLVARPEDMSEEQPEGVPIVAADHKLSSAEEFESKRNKNVINRDDGTVVPDEIYSFPATCSSCGHQLETLMQQVNIPYFQDIIIMSSNCYACGYRDNEVKSGGSIAPKGKRITLKVEDEEDLSRDMLKSDTAGLSIPEIDLVLQPGTLGGRFTTLEGLLNEIYTELSTKVFRAGDSTTAGIGQTDSSAGEDEANFGDFLKGLKECMSAQRQFTLILDDPVSNSYLQNLYAPDPDPNMQIEVYERTFEQNEELGLNDMVVEGYNKEAEGTA
The following text describes a protein:
Function:
Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.
Sequence:
MSEKKRTSEELEDIISRYRKESRSRSVEESGLTKETSNLLKEDSDETSSNQIYETHPSKNTLASSSGSKSKKNEEQRKSLQFSETITTYDSLQSKTGISQNSSLSETEMRAEYQAFVDSLSHETLGKISPQLSEENQKGSGLPSDNFTINLKAKGLQEFPKDILKVKYVKYLYLDENEIKSFKGADSRDMLGLEILSIQKNGLSTLPSEIQLLHNLKLLNVSYNQISHIPKEISQLGNIKELFLNNNCIEDFPSGLESLKNLEILNLAKNKLRHIPDALSSLKNLRALNLEYNRLTIFPKALCFLPKLISLNLTGNLINSLPKEIKELKNLEKLLLDHNKLTFLAVEIFLLLKMKELQLTDNKLEVISNKIENFKELRILILDKNLLKDMPENISHCAVLECLSLSDNKLTELPKNIHKLKNLRKLHINRNYLVKIPEYISHLNNMFSLEFSGNFITDFPIEIKSCKNIAKVELSYNKIMYFPLGLCALDSLHYLSLNGNYISEIPVDISFNKQLLHLEFNENKLLLFSEHLCSLINLEYLDLGKNKIRKIPPSISNMVSLHVLILCYNKLETFPTEVCTLDNLRVLDLSENQIQTIPSEICNLKGIQKLNISNNQFIYFPVELCHLQSLEELNISQINGKKLTRLPEELSNMTKLKGLDISNNAIREMPTNIGELRSLVSLNADNNQIRYLPSSFLSLNALQQLNLSGNNLSVLPSGIYNLFSLKEINFDDNPLLRPPMEICKGKQLYTIARYLQRADERDEKILAKIFKIVAKNITETHFQFLCQKLNLTISESDKSALSTVSLSERVHQVLDKWKMEKNNLSVTTAALRDQLTRALTMIGAYEIMDKITALKLFSCAIKF
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Sequence:
MSLSRHALQDAAQRFGTPLYLYDAEELDAALWRVQRAFGDARIFYAMKANPNLNLLRRYAAAGVGFECVSLGELLRAEAAGAGGERMILNGPAKSDAEYAAAARLGATIVVDREEEVVLLPPGSRVLVRVNPAMTVSTHEHLATGTARSKFGLTPEQVPGTLAELRDAGHEVLGLHMHIGSAIEQAEDFTAAFARVTELRAHIGGLSVLNVGGGWSLNADLEGIAYEAHEAARVFGAELWVEPGRYLVASAGWLLTRVVGTKRTGRNFCLVDAGMTEFLRPMLYGASHPLYPMWDALATEVWDVAGPACESGDLIARGVPLPTPQRGHLLLIGEAGAYGASMSSTYLSRPRPAEVLWTGHDWQLLRRRETPQDIWAAEV
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
Subcellular Localization:
Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.
Sequence:
MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRLDTKSTGPKAPITDIAIIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYKRGRDKPPLTDIGVLYEGKERLIPGCEVILATPYGRCANVNNSSTTSQRIFITYRRAPPVRPQNSLAVTDICVIVTSKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSESDVPLFCLPMGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCLFSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKKTVQRSQVSSISGGQSDQGYGSKDELIKDDAEIHVPEEQAARELITKTKMQTEEVCDASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISNVLFSTQDPVEDAVFGEATNLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGADAKILTAALTCPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQELLEPVVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGLDPLSLLATECTGGKTPDSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELHREENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDVQTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI
The following text describes a protein:
Function:
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Miscellaneous:
MISCELLANEOUS: Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG).
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Lipid-anchor. Note=May be part of the cortical cytoskeleton.
Domain:
Polybasic regions located between residues 266 and 557 are involved in binding PKC.
Sequence:
MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES
The following text describes a protein:
Function:
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
Sequence:
MKPTQDKVAVVLAAGKGTRMKTDQPKVAVELNGKPLLLHVLDHLKGSGVERIVVVVGYKKELVQSLCSKIPGVTFAEQKEQLGTAHALLCAETELKNFQGSVIVACGDVPMITSETFSNIVKQHKENEFSATILSAVVEKPTGYGRIIRNSSGEVTAIVEEKDSSTEEKLINEINTGTYVFDGEGLFDSLRKIGNQNAQGEYYLPDLVKLYRNSGKKLGAMKLKNHLESHGVNSPEDLQMLSALIKGEAVHP
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
METAQFVYLPKACFPAKVIAWKVNVNDIVAKDQSLGIYEFTETVVEEPEHIPGATVSAVPKTSQKRTRREIRTVYEGRVDSLGAKPGDTIEDPKHALIVIVEPCGHPVQLNGLCAVCGKDLSIADYTGTDMERATIRMTHDASGITVSHKEAFRLEKETADRLLDERKLSLVLDLDQTVIHATVDPTVGEWMADPNNPNFPALTVWATHEPGTREFLRELNAKYEMHIYTMGTRNYAKAVSKILDPDKRYFKDRILSRDDSGSFSVKSLQRLFPCDQSMVVVVDDRADVWHWSPNLLRIKAYDFFVGIGDINEPVYAAAAELTDLTKAKVSHKPHIGSSAPPESTFSVVQDIPELEDSKLDPDTDSDSETSENKAELLAKMQDVQMLALKDQQNNRPLLHCQEELDIQTALLTSPTDNNASDLITTVIDEGSFTSTTAAPRQSQAMGQPQVSTAISASVASTSTLRTPTSDLISNNTSIVSKQRPVLIDTDRELNLIKSLMMYIHQTFYERSDAGDIKTSDVRVIVPEMKRSILEGVHILFTSIIPLGLEPQKHEHWIAATSYGAVCHVDLDPEVTHVIAGKTGTAKVNAARKRPNVAILKIDWLIDTIRTWQRADEVRYLLYLDHIPVNLPPRCINSFFLDSAPAASTLMEDRSSISDQDELLIVQGKWEHANEIYEKVGGDDWKEMDAEVDMAMMDDDSSDITGDDDSADAVEKFGAQSASINSTSSNSGGKTSKDSVDALQDDDWDSLADEIELGLEEVLTNTQPKSKSSSRVSTSSEYVSNQSAASVDIAMFPARPRKPSPLGQYQTASNSLEQTSLADGQETGDDAYFDQMDAWEDDDENMERIPKRKFDEYQDEDDKFDDDL
The following text describes a protein:
Function:
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein. In brain, involved in cognitive function, such as learning and long-term memory.
Sequence:
MRDLAEPYFDVWRLDRDSMIDHIEYMYHDLGVVRAWKIPRSTLRMFLLGVRERYQDNPYHNFKHCFCVTQMAYSIICKLRLRNKVSVDHLGALLTAAVCHDVDHPGLNNSYHCHARTPLAILYNYKSILEQHHFAVACRILSNKERNIFRNVNNRDEVLTNVGDLILATDLARHKDVMETYRCNIDTGFDFKNNSHVLSLLKIIIKCADVSNEVRPETVASPWVDRLFAEYSEQSAREKRERLPVTTYMDPDLVNVPESQEGFIRGIMLPMYDELCRLATDARVYFVSPLHEALLRYEIQNMRERVMKTFQFSSRI
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLTVDSIQQRLGGYYTQLTSTRAGSAVLALFALYVVQKFAQHRQRVAARKAWSNTTSEVAVVTGGSGGIGMEVVQRLSARGVKVAILDLVEPKGGILSNTVRFYKADMTDYDSIAAAAKNVEKDLGAVTILVNNAGVANDGPSILEFDPKKTKLTIEVNLLSHFYTLKVFLPHMIRTNHGHIMSVASAGSFIMPAGGADYGATKAALVSLHETLQLELELLYQNRTGVLCSIVHPYWIATPMTEAIFVPKFHKKMIKPEVVGSKMVDQLLSGQGGSLYVPGWIGRLAWIRVLPHWMAHKIRIQGTLDLAKNKREDRPNPPMP