lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in membrane remodeling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEASFIRSLPSAGNFANLLPTGTALIFETLLPSFSNGGECNNKPVNKLLTITLISFCAAACFFSSFTDSYVGQDGRIYYGIATSNGLHILNDYPDEGYDPESGLTADKRERYKLSFVDFVHAFVSVIVFLALAVESSDFRRCLLPEDDENSWGGHFVLMIKYFAVMVLTMASFFFAIFPSKRRGIGISDIR
The following text describes a protein:
Function:
Accepts electrons from ETF and reduces ubiquinone.
Sequence:
MSPPIRYDLLLVGGSASNLILAHRLLDLAGKSGLPLTIALVEKSAQFGAHIVSGALTKTHVLEKVFPDFKTNGFPIEGYVTHSHLSVLGSEERWDLPHAIVPKGFRKEGHAILTLSHAIRWLAEQLQAKAKELPNVLLDVFPGFAAQEILYEDQRVAGVRVSASGDVFEDAIFAEFTCFGDKGFLSKDLVERFALRPNPQLWSVGIKEVWEVDLDCRGVVWHTLGYPILDGTFSGGFVYGLGHKKLAIGLVISLDSKNPNLNPQLRLQQFKAHPWIQELIQGGRLLKYGAAVIPEGGYYSLPTRFGVEGALLLGDALGVLDAASLSGLDKSMETGYVAAELLHGAFVDRNFEGLTERYKSAVMDGFIGQELYASRHFRRAFLENDRLLGEYLPAVCQSVDQGHPWLGSLKFGLGKPIQRSTDTFQALGLILGRISGDKIFRYTPCHENIEPAFTQPAVAVSTQARPETLLSRPDAVFFAAPRYHEGNRHIEEFDADTCRRCIAVYDRLGKPTPCIADCTAEVHRIDEAGGVRVHGMSLENCIQCRTCEIVCPSVNLRVNPTYEGSGPDFYGL
The following text describes a protein:
Function:
The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. Activity is inhibited by OAF1 under non-inducing conditions. Activity is repressed by glucose.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif (residues 985 to 993) is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MYFTDESSPAMNRVGKKRNRLSFVCQACRKAKTKCDQEKPRCGRCTKQNLFCIYDVARQAAPRNPNKDATIARLKKEIRYWRNKTVDLTQEKKDFYTALKRPTEELAARRTCKSLQENSFPISLYKTHPRLIMTKVMKREINPLSEKYLIFQDTFLKTLIASVLLSCSRNSMIPALNADISRSRTQPCVKNNVVKMREVLLKNSKYESQRKSINEFTDRLLQRKNPEEQIAVNKVISLLYSNRESSYLEDTCPTENDYSDLLKGYINEIEKTLPPKAIIEQYLSHFFEHIFHLIPFASKEMLEESIHTTVQYNELGEVRLSMGTTLIRNKMENLCILLLILRIAYISLTFIEDKIEDYSPYITKEMLEQYPIQSEVIFLAQQILASENWCACANENTISCLLYIWCAFVFSPTEGDFLLEQPSDVIINLVILIGTSIGLHRDPSDFPALNHPEASDKRLLNLRRIQWLSIISMATLESSLKGRLLVSPLSMIDLFIDVRDPNCVEIYKKRVKKDLTGSESDEQLLEIHEIFFHRAQLALFLSDLNNITISYSGSVPMDTLETLRVKANELLKNKFQLRSVDINIYDEEKTFQKLTFNSILNSISLSGQILGKLMMLRASIALMLYFETLAMERSECLSFFYKYFFQCCADTISLIRFFFLYFNGSYEKVLSSLVCFITTKVIQLAVPTTMFTLLVIIMRVELAKNMLLVKCNECNARGDISDLPEIKEKIKSLDTIKENFERLLLEVYLLASQNLRFKYFYIFKMLTLFDVFIQRLRKGQLFSGLFVKVDKDLTTKKIATMLELTLGINLDKSDHLIDRLKGKNLTVNFTLDQLYQIIKEFDRIKNIGVADPQNSLNPSKPNMKDNTPTIELLLNSSVENESVPPYSSSNDPTNVGNASTYSLAHNISNQNNEENMPPSIGSSESNRAAPNLNFMPINNNYNNSGSNINNNDNVKLPSNFKNYYDPPMSSLDISMDVPDIFGSLDFFDYDLLFQND
The following text describes a protein:
Function:
May associate with G-protein coupled receptors and regulate downstream signaling pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGTVSLAVQLFIVFLLTSYLLNKYSTIRKQNPIVTISTFIGWYFSLIIVFVLPLDVAITFFHKCENDRQRVLNTTSTPAPIVPECELPGGYVPDDVLFDLWRVVYWSAQILTWLILPLLQSYVTAGNFTIFGKIRAAVINNTVYYAIYSLCFLAILIYAMFKGVSINIENLKVILVSASNTWGLFLLVVLLGHGLVELPRSLWHHGNRHYRLRKTYFDIEKLASEKSEAEENVKEIYKKVRVLFNSMKNDQNGQRRKVRTILSKFSDDVIDQLFPSRQVIDNASMEEIGDYCSEAKLINLHKKTIYAVQTLNNATAQWKVLVDRALFLENLAFSESNGYNLDLARNICVPVGVRRFWYTRLQTPFCRVLGVVTVFMTFFVLFSECTFFVVSYTVSPAAFVTEYASNRFHYKYTQFVAFGIIVYLITCAYFTIFRLQIYKYYHLDPNGHTDENSILFSAILLCRLTPPICLNFLGMIHMDSHVSMAKSFGVETQFTKLMGHLDVIPILAKGINIYLPICIILLCAIHYYRVGAYVLHNIGFDQFVESDEMTNDMINSGRSLVQIERNSIKRSNERNQRNQSWTNTITSNTSTTSNAVNKYKRSRKNEEERPMLEEEEEMEEVSSTTRISLSPTEHPSSSGFFDDM
The following text describes a protein:
Function:
Protease that triggers late cell apoptosis and contributes to the pathogenicity and dissemination of M.tuberculosis. In a mouse model of infection, can induce hepatocyte and lung cell apoptosis and cause pathological damage to the spleen, liver and lungs. Specifically stimulates the secretion of inflammatory cytokines including TNF-alpha, IL-6 and IL-1 beta. Can degrade casein in vitro.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Secreted, cell wall.
Sequence:
MTWQIVFVVICVIVAGVAALFWRLPSDDTTRSRAKTVTIAAVAAAAVFFFLGCFTIVGTRQFAIMTTFGRPTGVSLNNGFHGKWPWQMTHPMDGAVQIDKYVKEGNTDQRITVRLGNQSTALADVSIRWQLKQAAAPELFQQYKTFDNVRVNLIERNLSVALNEVFAGFNPLDPRNLDVSPLPSLAKRAADILRQDVGGQVDIFDVNVPTIQYDQSTEDKINQLNQQRAQTSIALEAQRTAEAQAKANEILSRSISDDPNVVVQNCITAAINKGISPLGCWPGSSALPTIAVPGR
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKSGRSKNKVKRSSKTLPKGIPTRKSTPGNNTTSGPSPFEYARTTNSATRVKHHVHNRIVPGQLKPNSLGRGGASNARSTQSSLARSIQRRQTHLKSQLQSEGKANSFIDRRIGEAGRRHGLVEDGGGGRTKEDVMLKRIVQERVRRSKRAGKFSLEEEEDDGGGGGGLTHRVGIVMVYCILSLFMFSTLQCTNHTNHDSAQRLPQGKTIDESYTGKPQDEMDIILSDDDQDDLDKVDTMMHFGGGKFDKDNAIERGAYGGEGGQGGQDLGVAYRSRKEELEDRIRMKKFEKAERMKRKEDQAETFETMDESFAELAQLLQFRDKEQERTEKAKARKMGTLNADDVEMDAWDKEMKEYLFERKVKATDRTKTPEEIAKEEADRLHKLETRRLARMAGDFEEDDLSDISDDEGGRKRKRSKKEQSKKKRDHSNPEELSDSEDEKEESGDRREVRFTADGLVYLDKDGNVVGKVGEEKDEENDAISEEESDGSDGDLSGSEEEDSAAGHDLGDSVDEASAANSDEDGSDEESGANPVELTKGMKVQGNYRAKEQYGGKENWYNGEITAVRKDCNGNTVYDVTYEDGDFEDGMIQSNVRALPKSQEEKEAEMARETEVSLAKKKKLKAKIRAKETIPFVFEVPTTLDSLHNVIATHASTGADASLIIQRIHTTNSVRLNHKNKERMQNFYDVLLRRFIAVGDAIFESGNGGPDLERYEQLNSITKTLYAMSQDSPECAGAVWSRRLGIFQKAFAKRLRDVEVVQLGDACEGEFTAWPSTGMLLLMRALPHIFPSTDKRHAVVTPALVLLGQILAQTPIYSQYDVVMGLFCSGLMIEYTKDAKRLPPEATAFLAGVLRLFADDVAAALSRSPLPSLGSTSKGSTLLNLRKELSDLINEGDLGLNNIRLSLEKDDIQSEANSLSTISFALHLVQQAINAFGKTEEGSEREIFSEVMKAMLCIDGSRKDLTLPLSVKNAIAETARVASSTCASGEERRPLQRRKAASAKDLAIKTLAPRMEDPSRYSMSKDKGKTQLQAEHDRHRREYKREHKAAMRELRLDSAFIESERRKAKDAADGKAKEKRHKNFAWLEQEQATMNQQVRMGGGLLSGGGVGAAKRKAKSGKLGIKKGGKLR
The following text describes a protein:
Function:
Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation. Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.2 to regulate autophagic processes.
Subcellular Localization:
Cytoplasm.
Sequence:
MADSYRKLIIERLEDVKQRNKQTATLYNNYSKLAEQLEKKHKYGTSSSNSSQLETGELARVKEEMAELYRSKCQNDQRLIDANHRIADFEKKSSAIIAEKIALEATAKSICAKYAKTEVELQRLKVDNDQLNDERIASNTTVTMLTKQIQDIENDRIHFLNKIRELNEQRVDFLNAEVALEEKRRNSRIQDMITSAVQDITDKDTKLEEMLRAMPDTNSNGDLLLGDSVPSRAEFVLECEEGEVNDVHWLDGETFATGGSDRNIKIWKVDGHGGYTRIGTLAGSNAAFTRIDYERDRKHFIASSNDKNVRIWNLDNSRLLSTLSGHSDQVTCVKFYQSHSAVSGSADRVIKIWDIQNQRCSRSLFPASKVLDVATNMGASPSLFASGHFDKKLRFYDGRSTDPVRTVDMGGRITSLDVTMSGCELLVSTRDDTISLIDLRTFQTVHCYSAENYRTSSDLSRVVLSSGNEYVAAGSSNGSIFVWNRNSTKLEKQLCSNSENAIFSLSWNPTGYGLLSSSKQKFVTLWK
The following text describes a protein:
Function:
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism.
Subcellular Localization:
Cell membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Zymogen granule membrane; Single-pass type IV membrane protein.
Sequence:
TSAARRPAGKRQDCRDGPWPAAPGSLLGGKGRSEETGRGGAGAKKGVALPGDGEAAAIPARAVFRRGTGLVPEASRGPSALSTLSRLGVPPTSHEASAGCCVPAVLLDEEGSGGEGNDRVRDLRSEVEGVKNIMTQNVERILARGENLDHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVLICVIVFIIVLLIVLFATGVIH
The following text describes a protein:
Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRTGVSRAMAVTTGTEGGAALKPSGKVDSALVEKAVDALLKWSGSLKGKDKSQLLEDDQLLYVVVGLNKVPDRGRTNPYSVTLPHPLFQLDENLEVCLIISDRENTKLKMSKETAKERIEKEGLNIRKVISSSKLKKDYFSFEAKRKLCGSYDLFLADDRILGELPKVLGKGFYKKKKHPIPVNLTRAQWKGQIMSALSSTFVYVSGGTCSVVKVAKTSQLREEIIENVKAVCEGVAQQIPKKWANIRSYYLKTLESISLPIYQSLPDMPFKIDLPGLSQPDANQGMKQSKKKVRLAEVKKEKVDGSFMSESEDKTVVVQDTVAFDKSKKRKQRNVEGKPKKPRTKA
The following text describes a protein:
Function:
Required for axon extension during neural development.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MMGPFGSLCLAWALLGVARACPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFVNVTQVTSLWLAHSEVRTVESGALAVLSQLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLEPGTFDALSALSHLQLYHNPFHCSCGLVWLQAWAASTRVSLPEPDSIACASPPELQGVPVHRLPALPCAPPSVRLSAEPPPEAPGTPLRAGLSFLLHCVAEGHPTPRLQWQLQIPGGTVVLVPPVLSKEEDGGEKVDDGEGDGDEDQPTQTEAPTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGIYTCRAHNELGTNSTSLRVTVAAAGPPKHAPGTGEEPDAQAPTSERKATTKGRSNSVLPFKPEGKTKGQGLARVSILGETEAELEETDEEEQMGGQIPADPMGEKHCGHGDPSRYVSNHAFNQSSDLKPHVFELGVIALDVAEREARVQLTPLAARWGPGPDGASGARRPGRRPLRLLYLCPAGGGTAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVTVSVFLLVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPARGEAGGEEPEEVPEEGLDEDVEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYSDRLPLGAEAVNIAQEINGNYRQTAG
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPCECSKTGSCNCGGSCKCSNCACTSCKKSCCPCCPSDCSKCASGCVCKGKTCDTSCCQ
The following text describes a protein:
Function:
Intracellular thiol proteinase inhibitor. Inhibits papain, but not cathepsin B.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLGGLKPEVHAANDEIRQVVAKVADELKSKLNTTEVEPVSYKTQLVAGTNYFIKVKTPAGFAHARVYKDLQQNHSVHSVKADGITEESEIVYF
The following text describes a protein:
Function:
Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, NECTIN2 and TNFRSF14/HVEM, promoting the virus entry into host cells. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs.
Sequence:
MGRLTSGVGTAALLVVAVGLRVVCAKYALADPSLKMADPNRFRGKNLPVLDRLTDPPGVKRVYHIQPSLEDPFQPPSIPITVYYAVLERACRSVLLHAPSEAPQIVRGASDEARKHTYNLTIAWYRMGDNCAIPITVMEYTECPYNKSLGVCPIRTQPRWSYYDSFSAVSEDNLGFLMHAPAFETAGTYLRLVKINDWTEITQFILEHRARASCKYALPLRIPPAACLTSKAYQQGVTVDSIGMLPRFIPENQRTVALYSLKIAGWHGPKPPYTSTLLPPELSDTTNATQPELVPEDPEDSALLEDPAGTVSSQIPPNWHIPSIQDVAPHHAPAAPSNPGLIIGALAGSTLAVLVIGGIAFWVRRRAQMAPKRLRLPHIRDDDAPPSHQPLFY
The following text describes a protein:
Function:
Required for spore wall assembly.
Subcellular Localization:
Mitochondrion. Membrane; Multi-pass membrane protein.
Sequence:
MDFMSPKFSLTDVEYPAWCQDDEVPITMQEIREIFVELMDKFGFQKSSMENMYQHLMGQLDSRASRTGAQNALVSLHVSYIGGEHANYRKWYFAAQLDLDEEIGFQNMRLHGKARQRNVKMAKKRGVSIKEQIKQWNEKEQEFINNHPKITLTQEQLEDQTNLKSADYKWKLKMKKLTPENMIRQLALYLLCWGEANQVRFAPECLCFIFKCALDYDISTSSSEKTVKSPEYSYLNDVITPLYEFLRGQVYKKDAKGNWKRREKDHKNIIGYDDINQLFWYPEGFERIILNNGERLVDKPLEERYLYFKDVAWSKVFYKTYRETRSWKHCFTNFNRFWIIHFAPFWFFTTFNSPTLYTKNYIQLLNNQPTPQVRLSVIAFGGTIACLVQILATVFEWGFVPREWPGAQHLSSRMIGLLFCLAINLGPSVYVLGFFEWDVHSKSAYIVSIVQLIIAFLTTFFFAVRPLGGLFRPYLNKDKKHRRYISSQTFTASFPKLTGRSKWFSYGLWVFVYLAKYIESYFFLTLSLRDPIRVLSIMDLSRCQGEYLLGPILCKWQAKITLVLMLLSDLGLFFLDTYLWYIICNCIFSIVLSFSLGTSILTPWKNVYSRLPKRIYSKILATSEMDVKFKAKILISQVWNAIVISMYREHLLSIEHLQRLLFQQVDSLMGDTRTLKSPTFFVAQDDSTFKSMEFFPSNSEAKRRISFFAQSLATPISEPVPVDCMPTFTVLVPHYSEKILLGLKEIIREESPKSKITVLEYLKHLHPTEWECFVKDTKLLSMEKSFLKEAESSHDEDRLEIPDALYDPRSSPLSDHTESRKLPTEDDLIKEKINDLPFSYFGFNSSEPSYTLRTRIWASLRTQTLYRTLSGFMNYSKAIKLLYRIENPSLVSLYRGNNEALENDLENMASRKFRMVVAMQRYAKFNKDEVEATELLLRAYPNMFISYLLEELEQNESEKTYYSCLTNGYAEFDEESGLRKPIFKIRLSGNPILGDGKSDNQNHSIIFYRGEYIQVIDANQDNYLEECLKIRSVLSEFEELELNPTIPYIPGIEYEEEPPPIAIVGSREYIFSENIGVLGDIAAGKEQTFGTLFARTLAEIGGKLHYGHPDFLNGIFMTTRGGLSKAQRGLHLNEDIYAGMNAICRGGKIKHSDYYQCGKGRDLGFGSILNFTTKIGAGMGEQLLSREYYYLGTQLPMDRFLSFFYAHPGFHLNNLFISFSVQLFFVLLLNLGALNHEIIACFYDKDAPITNLETPVGCYNIQPALHWVSIFVLSIFIVFFIAFAPLLIQEVLEKGIWRAASRFLHHLLSMAPLFEVFVCQVYSNSLLMDLTFGGAKYISTGRGFAITRLDFFTLYSRFVNISIYSGFQVFFMLLFAIISMWQPALLWFWITVISMCFAPFIFNPHQFAFMDFFIDYKTFIHWLFSGNTKYQKESWANFVKSSRSRFTGYKSKTVDDISEDSGHDSKKARFWNVFFAELFLPFCVFLFNFTAFSFINAQTGVSDSTPTSAVFRLLLVTFLPIFLNSIVLFLLFWVSLFVVPGLSYCCKDAGAVIAFIAHTFSVLVYLLDFELMWFLQGWNFTRTLILLITCINMHLILFKVFTTIFLTREYKNNKAHLAWWNGKWYNTGMGWSIILQPIREYFVKIMESSYFAADFFLGHFLLFIQTPIILLPFIDYWHTMVLFWMNPRSIIAHKRILTRKQRALRSRIVSKYFSLYFVMLGVLLFMLIAPFFAGDFVSSPQELLEGTLFEGIFQPNNQNNNDTGPNAPSTILTTTPTLPTFRTVA
The following text describes a protein:
Function:
Involved in degradation of glycine betaine. Part of a Rieske-type oxygenase system that catalyzes the conversion of glycine betaine (GB) to dimethylglycine (DMG) (Probable). This subunit is the ferredoxin reductase component of the system (Probable). Required for growth on choline and GB, but not for growth on DMG.
Sequence:
MSSNFLNPVTTQTWANGRHLVRCVKVIQETWDVRTFCFMADQPILFFFKPGQFVTLELEIDGEPVMRSYTISSSPSVPYSFSITIKRVPGGRVSNWLHDNLKEGQELPVHGPVGLFNAIDFPADKVLFLSGGVGITPVMSMARWFFDTNANVDMVFVHSARSPKDIIYHRELEHMASRIDNFSLHIICERHGLGEAWAGYRGYLNLRMLELIAPDFLEREIFCCGPTPYMSAVKHLLQGHGYDMSRYHEEAFGPTPPEVRADVRELAAEAAEAPEVPVADQHQVEFTATGKSIRVSPGETVHAAAAKLGLHIPKACGMGICGTCKVMKTAGEVEMEHNGGITDEDVAEGYILSCCSVPKGDVVIDY
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Nonessential member of the complex that stabilizes the interaction between the essential proteins BamA and BamD. May modulate the conformation of BamA, likely through interactions with BamD. Efficient substrate folding and insertion into the outer membrane requires all 5 subunits. A lateral gate may open between the first and last strands of the BamA beta-barrel that allows substrate to insert into the outer membrane; comparison of the structures of complete and nearly complete Bam complexes show there is considerable movement of all 5 proteins.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MRCKTLTAAAAVLLMLTAGCSTLERVVYRPDINQGNYLTANDVSKIRVGMTQQQVAYALGTPLMSDPFGTNTWFYVFRQQPGHEGVTQQTLTLTFNSSGVLTNIDNKPALSGN
The following text describes a protein:
Function:
Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.
Subcellular Localization:
Nucleus.
Sequence:
MWGSRYIQAERQDSLTNRIEHVLGDMNEVQKHLGSEPNIWLGTSRNQQNLSRSQTYRNQGPQNHSSRSKPQSNSSVYSPGQEKSQIGSKRRDESSQQNNFYPKYQSSNLSRHNHNNNTSDRISSTPLPDHKGRSKSPRNGITEQAHNRERLQSVDMPVAVENIFKEMLQMNEPLSEIQTPNIGQEFNFVKSETKIKEEPKEKSHAVRPDLEDNAATMSSSDENSSDESDEESDDSDAEEGTNKWVLSGYLDDSAAANDSVTEQKPEAAKQKNAESSHSSTRKAVTRGRPSERKNSVDTKTRNSSSRSSSVKGKTDDKSSERSKSASKGRLGSSHRSSPVRSQSLQRPTKPSSKAVQDVKRNNNKQSPLSERKSPVPKPQSNEQSANRNCNNSMLFSVSNETSSQTPSDQRHRVGQKSPMTAIKNHGRIAEKKHRGVSPSSQSSSDSSCSGSEDEKSPTRWNSFRERSNSSSSNKPSVHSKKQNNSKSSIDRRSAPSALAKPDMDRRKPPKPDQSNLRPPISQHDVKHRHPRSNESTPTSQETREGSVAKQPNPQSRPKSKKSSKQRRSVSSPVTNEPKPSSFPSLWVRILPSSSNDPEESYPDTHAPMDTFQPEPRPRSSTNRTAAVSTGSETEKPLQRAKNVQVAVAASSSDWSPRTAMNKRKHNQPYDSTSVADQKSKRRKQETPSPTNSQGRQPTHSIAASESSQHSRKENFQWKDRRKGSRSPHNPSWNQEPTYNQNQPSSYHEPANNIRPPQVKLETCQSTSHSASAGVASIVSEPDSSWPEQEKLLKSDQYMREGKRLKHEGDAFTDSRTGRTRVGESLSRALVYYDAALCFIMNGYTLELENGNDRNESGSSHSPTSMYHQTISLMDYIRKMRPHDDTEELAFKRLNLSCIRSQALLFLRIYKLKKDIANKYSEILNDQFKQTGNKSNRTPSPWHNVSGQNVVSPMSPAVPSPYGITIPGPSPVAGSTNYEPVSSSTQVSKMTSPPTSSTISVAPKLYDIIKHYHSITRSLMLAHEKWEQAEALQKEQVLSGGGTDFFRNVETLCGRTLMLHSSLRDLVTYNKVVLHQLRAIKSPHD
The following text describes a protein:
Function:
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Sequence:
MASPVNQQLLHHTEVRCDGSGDGSSVTVRINRQHHQAPSRRCKYSISSSCSSGESGVKKTGGSGGARRQKKLPQLFERSTSNWWNPKFDSNNLEEACVERCFPQTQRRFRYALMYLSVAGLLWSIYFSVHMKTKLVSHLVPTLCFLIVCLGFFFFTFTKSYARHCTAISLLVTLLVFTLTLASQFQVLNPGLGSDSLSNLTSFSATGSSSCLSQVGSFSICVEVLLLLYTVMHLPLYLSACLGVAYSILFETFGYHFRDESCFVLLVGRMAHWELLSKALLHVCIHAIGVHLFIMSEVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDDESENSVKRHSASSPKSRKKKSSIQKTPIIFRPFKMQRIEQVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRPDHAYCCIEMGLGMIEAIDQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEKTARYLDDRYLMEDSMVVERLGQIVAADQLKGLKTFLISGGRTRVPSCSCSQTLIPVQEGTDLSSPSLAPHVQAAISETSDSHTNCTQPETLKSCPSCGETAARDGPEEGVSAANGGGEEWKGGAPRPSAIGASLKDPERSPESSTGDTLTNSQASLYDMLQEKGRWCGVSMDQSALLPLRFKNIREKTDAHFVEVIKEDSLMKDYFFKPPINPLSLNFLDKELETSYRASYQEEVIRMAPVKTFASATFSSLQDVLLNYFIFVLLSVACLLKPGTNTVSPPTLALVLLSVCGLLGFLSLLVSVRMAFYLEDMLLCTRRLLEIISGWVPRHFIGTVLVCLPAAVIFSYLSSDFYTDIHYTMFLCSALLIPMVQYCNFCQLSSSALLLATITGATMLILIYLPLCPQRPPLDPGTDIEANLSTSNSSYETLDNPRTELPFTRLGQEIAVAYFLLLLLVWFLNREFDVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQSYSKNHDDAGVIFASIVNFSEFYEENYEGGKECYRALNELIGDFDELLSKPHYSCIEKIKTIGATYMAASGLNPSQCQDSSQPHRHLQTLFEFAKEMMSVVDEFNNNMLWFNFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQASEESYRVLVKMGYDFDYRGTVNVKGKGQMKTYHFPKCTDNGGLVPHHQLCISPDIRVQVDGSIGRSPTDEISSLVTGGKGAVELGSGEAERKREKAEERGRDGGAR
The following text describes a protein:
Function:
Important for the siderophore-mediated iron-acquisition function of ESX-3.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLPAGLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGDEFLDMDSDSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MKITCTDLVYVFILLFLNTSCVQAVFSDDAFITDWQLANLGPWEKVIPDSRDRNRVLILSNPTETSCLVSSFNVSSGQILFRNVLPFTIDEIQLDSNDHNAMVCVNSSSNHWQKYDLHDWFLLEEGVDNAPSTTILPQSSYLNDQVSIKNNELHILDEQSKLAEWKLELPQGFNKVEYFHREDPLALVLNVNDTQYMGFSANGTELIPVWQRDEWLTNVVDYAVLDVFDSRDVELNKDMKAELDSNSLWNAYWLRLTTNWNRLINLLKENQFSPGRVFTKLLALDAKDTTVSDLKFGFAKILIVLTHDGFIGGLDMVNKGQLIWKLDLEIDQGVKMFWTDKNHDELVVFSHDGHYLTIEVTKDQPIIKSRSPLSERKTVDSVIRLNEHDHQYLIKFEDKDHLLFKLNPGKNTDVPIVANNHSSSHIFVTEHDTNGIYGYIIENDTVKQTWKKAVNSKEKMVAYSKRETTNLNTLGITLGDKSVLYKYLYPNLAAYLIANEEHHTITFNLIDTITGEILITQEHKDSPDFRFPMDIVFGEYWVVYSYFSSEPVPEQKLVVVELYESLTPDERLSNSSDNFSYDPLTGHINKPQFQTKQFIFPEIIKTMSISKTTDDITTKAIVMELENGQITYIPKLLLNARGKPAEEMAKDKKKEFMATPYTPVIPINDNFIITHFRNLLPGSDSQLISIPTNLESTSIICDLGLDVFCTRITPSGQFDLMSPTFEKGKLLITIFVLLVITYFIRPSVSNKKLKSQWLIK
The following text describes a protein:
Function:
Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MSRLINRLANTLRTLESYLFGGNGFPPGALALVHVHDGSPQPAAPRAAPFSLRDLLGDGMLWAVPKHRRTVEKRLKRKYGSPEYKLKILTPKVHLRTCATCGSDQEVGVLCPTCYKKVRTETELMQEKIQSELGLEPVDRDVVVLYDRERDEQPAEFWQGKRIVEMEKPRPSWFSKNLLQKSTQQQSEPDELKPGHEKLG
The following text describes a protein:
Function:
Component of the type III secretion system 1 (SPI-1 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (By similarity). SipB/SctE1 and SipC/SctB1 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells (By similarity).
Subcellular Localization:
Secreted. Host membrane; Single-pass membrane protein. Note=Secreted via the type III secretion system 1 (SPI-1 T3SS).
Sequence:
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQNTDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAKTTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGVDSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKDSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARKMQMTGDLIMKNSVTVGGIAGASGQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASALAAIAGNIRA
The following text describes a protein:
Function:
Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8-tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis.
Sequence:
MSNGRHLAKGSPMPDVPEDGILRLYSMRFCPFAQRVHLVLDAKQIPYHSIYINLTDKPEWLLEKNPQGKVPALEIVREPGPPVLTESLLICEYLDEQYPLRPLYPRDPLKKVQDKLLIERFRAVLGAFFKASDGGDLEPFWSGLDIYERELARRGTEFFGGEQTGILDYMIWPWCERLELLKLQRGEDYNYDQSRFPQLTLWLERMKRDPAVMAFYMEAEVQAEFLRTRSLGRPNYNLLVKDA
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Subcellular Localization:
Cytoplasm.
Sequence:
MNELTGADFKSATADDNKKLFIETYGCQMNVADSEVIASVMQMAGYSVAETLEEADAVFMNTCSIRDNAEQKILNRLEFFHSLKKKKKALIVGVLGCMAERVKDDLITNHHVDLVVGPDAYLTLPELIAAVEAGEKAINVDLSTTETYRDVIPSRICGNHISGFVSIMRGCNNFCTYCIVPYTRGRERSRDVESILNEVADLVAKGYKEVTLLGQNVNSYRFEKPTGEVVTFPMLLRMVAEAAPGVRIRFTTSHPKDMSDETLEVIAQVPNVCKHIHLPVQSGSSRILKLMNRKYTREWYLDRVAAIKRIIPDCGLTTDIFSGFHSETEEDHQLSLSLMEECGYDAAFMFKYSERPGTYASKHLEDNVPEDVKVRRLNEIIALQNRLSAESNQRCIGKTYEVLVEGVSKRSRDQLFGRTEQNRVVVFDRGTHRIGDFVNVRVTEASSATLKGEEV