lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Sequence:
MFVCRACLRKGLAPGALARINAPAVGSRLALPRLGALTPSQSTTTIRSYHLPALKPKTAADPSVTLDLEAPEGEEDGDGSEGKRKKRDLSDEQRKKLERSAALQLKHFKDPFHIEKQVKLTLDKGKYEEALVLTRKASKNAKVQVSWNHLIDYHMKNKRLSAAIKIYNEMKKRAQVPDARTYTIIFRGCAMSEHPKQAVAEAVKIYHSLLRNERVKPTTIHLNAVLETCARAGDLDSMFTTVQTANESTRKPDNLTYTIIFNALRAQFNPRLPLDRDPMQRDQEDINREKQEAINRGLQIWEDVQRQWKKANLMIDEELVCSFGRLLTLGTKEDNERVFELLSSSMQLPRFHAGEKAAAQVTAKAVDITTTPVVSSEAASPEATASEAPETTPTKTTTSGSTTPTVQPIETKPKFDKKPKSVTHSPSLYAKPGNNTLSLILSVLSNTRRTSLAQKYWDLLTSTPYSIKPDKDNYFRYLRVLQIGRGSAATAAVLQSMPAEFITPMILKTAFTTCIRDELNPHAFSPHACTIFDVMTKKTRYPDAIAMRLFLQSAQGNFRHIKKMAETDPLGSRQAMGKQIILALDKMWQPYRIMVNQYSYPIGSRVQAQSPEDAWKAVRAHMSECVVTARRMISAMDKVMLNSMCADDEILKVLKRRRVILQNMVERYVAKDGDMMGRWREKMVERYGEAGLKKREAEKKGASNAGEEYEFGQPKPNEFERNLNKKKEEAVAANEKRKAEQAQRPKEAEEENEEDEEEEEWEDITESRYPRDKTRSLRNELRRDEKSSSKYGYQQTSNNSSSWSRESQGGKWDRDSQQDRWGSSGRKPSW
The following text describes a protein:
Function:
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. Required for Cajal body formation.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Nucleus, Cajal body. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Detected in the CBs of cells from a number of different larval and adult tissues. In stage 8-9 oocytes detected only in the single CB of the germinal vesicle. Also detected in the histone locus bodies (HLBs) of late stage nurse cells, and low expression in the HLBs of large polytene or polyploid nuclei within the salivary glands, fat bodies and Malpighian tubule cells. In germline stem cells and cystocytes (where CBs are not evident), expressed throughout the nucleoplasm. During interphase localized to foci scattered throughout the nucleoplasm. During metaphase (in meiotic and mitotic cells) these foci localize to the centromere regions on the metaphase plate. At anaphase, no longer detected as foci and is instead detected throughout the spindle. When the nucleus reforms, it localizes to multiple nuclear foci and throughout the nucleoplasm; [Isoform C]: Cytoplasm. Note=Very low expression and not detected at the protein level. Relatively higher levels of expression in the cytoplasm of follicle cells that have no expression of Isoform D in their CBs.
Sequence:
MQHSSMKVDLSNFFKDERRNSLVFIDAAWNNIKDLQDHIQNLFSLKDISLLTSDGCYLPPRESIKVLNSAEGLKAFRFASHDSDTFVSPAPVKSSKKRKNRSVEEQVHLTASTPLRPSKRSKNQNNSEWINIAENPSRVRKKELLDMAPGPSVQSKLLTNKGTPKAPETQTEVSNMSANIETENKESAPQIKNKSKNKKPTKSPEASDQVENEPAPKSISRCTLKEGKMSESKNQETSPDILSEKSGVVTKENETREEQQDKTHLESNKIPDKLSQLKAGDQIEKSPGIAASLLSISFRSPLLEMPFNVPRIFQFPTKKQQIEILEYKKLKPISPRFLLQKGAKSDDTAKQFPSNGKDSTLKPKSYEILHDEELPDVKDKKNVSEGIKRAVAPLCEDIIETSTTLPGAIGAVESAYLDNSTEAETTLPSEAEATNPLELTESFLQNNTSMEKTPKVEKILPDDGSASPIKNNVDSKDVKTVTVPIFEEQLVSDSDDDVMLVDDSNIDVSYGDSDIEPIPVVENRQSLDIIRDLLRTATPLNSLPSRGDTVIFKLLKIKGNANSGTTEFVAGRCTYVNRRTKIVTVETITYPPEIGRMLRQYYMSGLDESSEDVRTLSIHLKDMLEAKIIVATID
The following text describes a protein:
Function:
Involved in the biosynthesis of the quinone methoxy group present in the mitomycin A and B, which are used as anticancer agents. In vitro, catalyzes the 6-O-methylation of both C9-beta- and C9-alpha-configured 6-hydroxymitomycins via the transfer of the S-methyl group of S-adenosyl-L-methionine (AdoMet) to the 6-demethylmitomycin A and B. It can also use hydroxyquinone as substrate.
Sequence:
MTVEQTPENPGTAARAAAEETVNDILQGAWKARAIHVAVELGVPELLQEGPRTATALAEATGAHEQTLRRLLRLLATVGVFDDLGHDDLFAQNALSAVLLPDPASPVATDARFQAAPWHWRAWEQLTHSVRTGEASFDVANGTSFWQLTHEDPKARELFNRAMGSVSLTEAGQVAAAYDFSGAATAVDIGGGRGSLMAAVLDAFPGLRGTLLERPPVAEEARELLTGRGLADRCEILPGDFFETIPDGADVYLIKHVLHDWDDDDVVRILRRIATAMKPDSRLLVIDNLIDERPAASTLFVDLLLLVLVGGAERSESEFAALLEKSGLRVERSLPCGAGPVRIVEIRRA
The following text describes a protein:
Function:
May be involved in several stages of intracellular trafficking.
Sequence:
MSGSSSPKCTPKSLPTSGQKSLHDIKHPLSCSPGAEDDAAAAGENGAVIIDSPSPDLPHTEPSSIADKDLSLPNGTPADTSSPASSSSLLNRLQLDDDLDGETRDLFVTVDDPKKHVCTMETYITYSVSTKTTRTEFDLPEYSVRRRYQDFDWLRNKLEETQPTHFIPPLPEKFVVKGVVDRFSEEFVETRRKALDKFLKRIADHPVLSFNEHFNVFLTAKDLNSHKKQGVTLLSKMGESVRYVTSGYKLRNRPAEFATVTDYLDTFALKLGTIDRIAQRIIKEEVEYLMELREYGPVYSTWSGLEKELNEPLEGVSACVGNCCTALEELTEDMSEDFMPVIREYILYSESMKTVLKKRDQVQAEYEAKSEAAALKREERSTVPTDVEKCQDKVECFNADLKADMDRWQNNKRQDFRQLLMGVADKNIQYYEKCLTAWESIIPLLQDKQEPK
The following text describes a protein:
Function:
GTP-dependent RNA ligase that is involved in RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases. Repairs tRNA cleaved by colicins D or E5, does not repair damaged 16S rRNA (By similarity); Able to catalyze tRNA splicing in vivo in yeast, but bacteria are not known to splice tRNA.
Miscellaneous:
MISCELLANEOUS: Ligation proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. Acts as a DNA ligase by attaching a GMP nucleotide to a DNA 3'-P to form a 'capped' 3' end structure, DNA3'pp5'G. When a suitable DNA 5'-OH end is available, RtcB catalyzes attack of the 5'-OH on DNA3'pp5'G to form a 3'-5' phosphodiester splice junction.
Sequence:
MNYELLTTENAPVKMWTKGVPVEADARQQLINTAKMPFIFKHIAVMPDVHLGKGSTIGSVIPTKGAIIPAAVGVDIGCGMNALRTALTAEDLPENLAELRQAIETAVPHGRTTGRCKRDKGAWENPPVNVDAKWAELEAGYQWLTQKYPRFLNTNNYKHLGTLGTGNHFIEICLDESDQVWIMLHSGSRGIGNAIGTYFIDLAQKEMQETLETLPSRDLAYFMEGTEYFDDYLKAVAWAQLFASLNRDAMMENVVTALQSITQKTVRQPQTLAMEEINCHHNYVQKEQHFGEEIYVTRKGAVSARAGQYGIIPGSMGAKSFIVRGLGNEESFCSCSHGAGRVMSRTKAKKLFSVEDQIRATAHVECRKDAEVIDEIPMAYKDIDAVMAAQSDLVEVIYTLRQVVCVKG
The following text describes a protein:
Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MESSKAELRRRMLAQPIIKKQTITATEVDPNKSNIQTKVVKAPVLYSSDGIPVARKLFDIIMLLKAEEKPLTNNDMVRKLAMDIMDDEELFDLVRNNERIFYDGVNGTFEYRASLIEFEYCVGIWACPTYKIRSKEDLLELLKKNRDTTGMEVKELKDSCNGIFGYIEELDAEKSILIIRNRDESPRIVYYNNNQLHVDICKEFKEYWHQVALPLEADISKELASAGLKSMEVIVMHKSAQGKAKTKAKRKTRFKLTNTHLEGIDLTKEFVPTLE
The following text describes a protein:
Function:
Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. In vitro, it has neither nucleoside diphosphate kinase (NDPK) activity nor reducing activity on disulfide bonds. Exhibits a 3'-5' exonuclease activity with a preference for single-stranded DNA, suggesting roles in DNA proofreading and repair.
Subcellular Localization:
Cytoplasm.
Domain:
Contains 3 inactive NDK domains that do not possess all residues considered to be crucial for the NDPK activity.
Sequence:
MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQSLFRKLKNELNEDEILHFVVAEADNIVTLQPFRDKCEPVFLFSLNGKIIAKIQGANAPLINRKVITLIDEERKIVAGEMDRPQYVEIPLVDAIDEEYGEVQYESAAEVYNMAIIKPDAVLMRKNIEVREKIAKEGFVIEIQENLILPEEVVREFYTHIADQPDFEEFVVSMTNGLSCVLIVSQEDSEVIQEETLPQTDTEEEPGVLEEPHVRFAPVMIKKKRDSLQEYMDRQHMSDYCDVEDDAVKVSKLIDILFPDFKTMKSTNVQTTLALLHPDICEEEKDDVLNVIHNEGFTILMQRQIVLSEEEARTVCKIHENEEYFDNLIGHMTSNHSYVLALRRENGVEYWKTLIGPKTIEEAYASHPQSLCVQFASGNFPTNQFYGSSSKAAAEKEIAHFFPPQSTLALIKPHVTHKERMEILKTIKEAGFELTLMKEMHLTPEHANKIYFKITGKDFYKNVLEVLSLGMSLVMVLTKWNAVAEWRRMVGPVDPEEAKLLSPESLRAKYGLDILRNAVHGASNFSEASEIISNVFTEGNPEN
The following text describes a protein:
Function:
Forms a heterodimeric complex in conjunction with mei-1 which severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May act to target mei-1 within the cell. Required specifically for meiotic spindle formation in the female germline.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Note=Localized to the spindle poles and condensed chromatin during female meiosis. Also localized to the polar body. Correct localization requires mei-1.
Sequence:
MSGLDDRKKLTHAKNRKPLNDIPKSAENRPNTRSTSSRRGAEKDVPITFIGSSRTVKADLPEFTNTRSRRPLHSESKKELSRNPVSRGEEHSSSLPKSSPESSVSVMSSNASLWSACTEEVNKIGVCAKRESRNLRVYKMKSFTSNMEQILSNDNQLAPTVIRILNSRNSWCLNSCHACLTFIMENITSDNYGKRSACLKALASITNSLLDTIIGFASTKTRRIGVDVVAEERAAKATECIHNFRKIVKNRDKIYKQIDQETIYKLDAILERLKKVSSHK
The following text describes a protein:
Function:
Required to stabilize mitochondrial cytochrome C oxidase subunit 2 (COX2) and to translocate the C-terminal domain of COX2 through the inner membrane.
Miscellaneous:
MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MQRFVSKFVSTPPVPKKFQEIFPKKRTVNKILFQLDTRLTYHEMYPIFLQVSQNTNEENIPWRKKYPYIRSSDIMQMRNVLITLRTQNKFVHKDLLAMEDKLLNIAAELGNNDAISILSFNVIHEYKKENVKSSYEKDIETANEFIKKLYARNHHLTVKLIGDLFFENKTYDKAEKYYQEFLKLENSTKLAGEVHGKLGEIQIKQVNGFLKAEKSWLSCIELLEIERSSRWYFLLARLYMSSEPMKAKALLENCASIGFKECFKTLGFLELNYFNNYERAKEWFKTGMEIMDLECFFGFFDCCVKEENFKGARDCLESVKKLGNDKDKKTMINVFLESRKDSIKLLDKARL
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
APKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHDAIIKFPLTTESAMKKIEDNNTLVCIVDVKANKHQIKQAVKKLYDTDVAKVNTLIRPDGEKKVYVRLAPDYDALDVANKIGII
The following text describes a protein:
Function:
Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: PubMed:12036302 reported that isoform 2 arises by alternative initiation.
Domain:
The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
Sequence:
MGQESSKPVWPNPTGGYQSNTGRRYGRRHAYVSFRPPTSQRERIASQRKTNSEVPMHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVRGKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQSSVASQSSSEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEEPVVRPKIRNLASPNCVKPKIFFDTDDDDDMPHSTSRWRDTANDNEGHSDGLARRGRGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSDKEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAGAGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL
The following text describes a protein:
Function:
Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MPTFRYSAYTAGGRETSGTIEAESLKEAKLHLKRDGLYPRDIGPVSETAGTVSRRFGGRNAGPAQVALMTRRLATLVGSQVPIYEAVTTLWEQEEPGEIKKALGRIRERLAEGANLAKALSLEPRLFSESYVAMVAAGEASGALDAVLERVALFLEEQRAIRSKITASLAYPTLMVLVGSAVMLFLLAFVIPKIVTIFEDNRAALPLITIALIKTSTFLRSFWWACIAAVAGVVLLYRRLMKDDAFRLRRDRFLLRIPVVGSLLRQLILSRFAKVLGLLLSSGVPVMRALEITAQVVVNRHYRAALTGVTAGLAEGGTLSGALRTTGLFPPLLVHMVAVGEKGGELEEMLGKAGSAFEREFESSVSGLMALLEPLLVLAMGLAVGLVVVAVLLPIFELNQLIR
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSNQFGYCPFLKKIIPVLKLTQTKLFVFLKCFLTTILAIFSIYNTFNKFANRLFVIRITAIVYIFLDLLYIGSIVVSELTFEHTLLNIVNHLMTMEEQLPKRKSASVVMLLGASFLSHIVTIGCVISFVLSEGYSNEWDNNVHVAHAINANLLKTWAHVKFTTIFFIISKDFEELNKVFYNCSNQKRRNVMHLHMTLSNISRQMNTIFSFVLVFSVAFYFVNLIARIIQIYCMYAFGTSRIHNHEAIGLAVETFRLLVVVWVSKRCMCQANEIKNVVCKILINTRNKVQRKEFNAYALQMFHETLEITAGGCFVIDFTLIFTIITAGSNYVVIILQFLYYDNQYTYRLRLWN
The following text describes a protein:
Function:
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells (By similarity).
Subcellular Localization:
Nucleus. Note=Colocalizes with ZNF224 at the nucleus.
Sequence:
MERQGAPLGPYRATKLWNEVTTSFRVGMPLRKHRQHLKKYSNCFTAVEAIDWLYDLLRSNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSESLDDNNQLFRFPATSPLKTFPQRHTEIKKTNTEYFSKDKDGIFKLRNLSQKTSKKRGLHFSQENTEKINHERITNEDLEIAPDNQEISQEDVEEVWRYVIMIYLQTILSLPSIEELLNPNQVIPQYIMYNMANTSKHGVVILQDKSDDLPHWVLSAMKCLANWPRSNDTNNLTYVGFERDVFKTIADYFLNLPEPLLTFEYYELFVNILVVCGYITVSDRTSGIHKIQDDPRSSKIHDLSNLNSFKSTECLLLSLLYKDKSNEELDSTKRLQRNDQGFQERCAKKMQLDNLRNRRASANDIMGGSCHNLIGLSNTNALSSNIKPRCSSLEGIVDRPVNSSEKKSSIFYQSVLNIEEQNSKQSLVSAPKQTPLFNLHSDENAQQPHCVGFNRTSALTVQDQEELCNEKYKSKQLCRSQSLLLRSSTRQNSCINKPVAEIIMKPNVGQGSTSELGESSTTINKRLCKSTIELSEKSLPPAASVLTGTQSLLQPHLERVAINALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPKLHEQIGTRSLMINTFSRCVLCCAEEVDLDELLASRLVSFLMDHHQEILQVPTYLQAAVEKHLDYIKKGNVKNHGDGLVVPLPTYSYCKQISAKEFDEQKISTSQAAIAELLENIVRSKSLSLKEKRRKLKQKEYPLIYQKRFPTTESEAALFDDKPTIKQPMLNLRNPKLHSLRY
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MAPRTPADKLGHASTLQLPTYDNDDQSSTNSTTPLHKDTPEETTDTSTTTNDVEPFHPPKLLSKTTTSPSIKLTSMLSKTSTKQNPNFPISLQSLSELHDPKSLKQLYDLGGIDNLLASLHTSFDGLNEHNETDLSQRKQYFGINRLPQKVQKSFLKLCWEALKDKVLVILCIAAIVSLALGCYESFGSGTHYDDEGLPLPKVDYVEGVAILVAVAIVVLVGAANDYQKERQFAKLNAKKEDREVIVVRNGGEQKLISIYDLMVGDVINLQTGDVVPADCILIQGEVECDESALTGESHTIHKVPVAKAMKVYQNHLPTNEDIGSTQIKFRDPYLISGAKVLSGLGNAVITAVGTNSIHGRTMMSLNHEPESTPMQVRLNDLAEGISKYGFLAAIVLFVVLFIRFCVEIAPNGNMNGAEPADKGKRFIDIIITAVTIVVVAIPEGLPLAVTLALAFATTRMAQNGNLVRVLKSCETMGGATAVCSDKTGTLTENKMRIVRGFFGLNKQGQPLEFNDTVGNQHDEPTSIDIINNEISSEQKVYLTTNIILNSTAFENSEYDEEKAKLARQKPPKQSFFSSLFKNSKKSQYQQMGLVDEPYLGNKTESALLTLAKDKFHLFDNKSLETCRQENNGDVIQVIPFESSRKWAGIVMKIPNGFRLYVKGAAEIIFKNCGFENNINDELIKLDRSKRDDVLSKIDEYANDALRAIALAHRDFVGISSWPPSELSSSSENKKTTTTAKEADPAKLINTSSSASEIHKMFILDALVGIQDPLKKGVAEAVLQCKRAGVTVRMVTGDNINTAKSISKECNILTSDDLSNEYSCMEGPQFRKLSIQKRREIVPQLKVLARSSPEDKRILVDTLRKAGEVVAVTGDGTNDAPALKLADVGFSMGIAGTEVAREASDIILMTDDFTDIVQAIKWGRTVSTSIKKFIQFQLTVNITACVLTFVSAVASSENKSVLTAVQLLWVNLIMDTLAALALATDKPDDSFLNRKPAGRTAPLISTSMWKMIIGQSMTQLIITFILHFAGKQLFFPGQSHINNHSEKQLAAMTFNTFVWLQFWKLFVTRKLDEADEITTIRGRISRENLDFFQHLFRNWYFITIALIIGGFQILIMFVGGAAFSIARQTPGMWATAILCGFLSIPVGLLIRIIPNIWIETIFPTKAFKKFLYIVGFGWLKFRKNKKTKDNEEDDEMDLEGGGNSDLKESKE
The following text describes a protein:
Function:
Converts phytoene into zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene with a concomitant isomerization of two neighboring double bonds at the C9 and C9' positions from trans to cis.
Subcellular Localization:
Plastid, chloroplast. Plastid, chromoplast. Membrane; Peripheral membrane protein.
Sequence:
MVVFGNVSAANLPYQNGFLKAISSGGCDLMGHRSFKISTSFKTRTRRRRSAGPLQVVCVDIPRPELENTVNFLEAASLSASFRSAPRPAKPLKVVIAGAGLAGLSTAKYLADAGHKPLLLEARDVLGGKIAAWKDEDGDWYETGLHIFFGAYPNVQNLFGELGINDRLQWKEHSMIFAMPSKPGEFSRFDFPDVLPAPLNGIWAILRNNEMLTWPEKIKFAIGLLPAMVGGQAYVEAQDGLSVEQWMRKQASSLLSFFGVPDRVTDEVFIAMSKALNFINPDELSMQCILIALNRFLQEKHGSKMAFLDGNPPERLCMPIVEHIRSLGGEVRLNSRIRKIELEDDGTVKSFLLTDGTTIQGDAYVFATPVDILKLLLPDSWKEIPYFKRLEKLVGVPVINVHIWFDRKLKNTYDHLLFSRSNLLSVYADMSLTCKEYYDPNRSMLELVFAPAEEWISRTDSDIIDATMKELERLFPDEIAADQSKAKILKYHVVKTPRSVYKTIPDCEPCRPLQRSPIKGFYLAGDYTKQKYLASMEGAVLSGKFCSQSILKDYELLAASSGPQKLSEATLST
The following text describes a protein:
Function:
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.
Subcellular Localization:
Cell projection, phagocytic cup. Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
Sequence:
MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTFSDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSMSDLSGSHMSSEKLKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDTSKMNQPDSIVDEGELCFGRQNDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENKREKREKVSLFERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPSSSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKFSNS
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MQNTYRGGGYYVGGSGDPSNWLCFLPFRHHCGRGRKEETKTDDVQPFPTFTQLPESMILAKENNIPEKDQMNKKNKKTVVHFCSSIASPHHHRRRHPLLLSDFPLLDRRYDYKFEKSRQMLPPLNEATGASVLVNAKQYHGILRRRRARAKQLIHTSSNKKSITDQKPYKHESRHLHAMRRVRGQGGRFLNTKEEKSPSFLETDVGNPNTDDLNDEDEVRGGFTTKWVKSAGGGRYYDLLKF
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
EFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTRCDLPTLPRPLPARLGKHKL
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MLKVVGASWHKTRIGSYILIGALMLAVAALFLADMERPSYNGTYCATTYWARNSGYRLEFWGQRNDLDQVPKGAVRACFRDSILTNGWSQLELESQSTYTDTVQAYAAGIMEGALTWHNIYMHWSNTIDAVCSKDEESEEFCDWLRGLITTNVDTVKKMADMKGKHDYYWYQIALFYDQLDGLEIGFRKGVKRSRMDYEIPKQDFLLMNAAVDIRDLKIYYTNFLMENSGLKPEPAKGIMLLKLLQQPNGQSKVLLGHTSDGSYSSMLRMVKKYTLRYHLSAETARTVVSAQAAEDEDRAVVPGTNIVFTGYPGVLASLDDFYVISGRRQHRLVAAGVKMENEHVDLWRKIDLVRSVSLAPRVMAANRLGHSGRSWARYFARNPSTGVKQWLVIDMSRFVGSNETEVELLATSPASVAVDQSVEDNDIAAEGGQDVVADGEHQRIVTKRMEDYVDDDFKEHLSAIRQVRMVTIPKAPEPVAGEELVVEPSVGHTFGSGMFWVVDQLPGRLHAEDITDKIVSDGYWLTNGVPYFKEALDIGQATANATNTTAPSSTMEKILQNITDLETLARFFRQSAYRGDLDQDEPAAFGNIDLKMYTETADGTVHFRAYSGPLYDPARSTPGQAAKRSIVKSEQLHQSTATDQKSAPASHGDSATVASHPFDWSRILPFEVRHQGHPDVWDFEHITPEWAWI
The following text describes a protein:
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Sequence:
HSGQEARWQGQGLGGTGTRGGVAPLTRALRWPGPAQRVNAHKPSGPSSTRPAPPPVLGGCVAKGGRGVPGVEASTPSAGALRRPCPAPLLCWPGRPALQGQPLATELCPVLGWPLSPPRCSPAHPSWSSLCQGRGPGGVPRAVSSAVRPGDEAQEGRTLRTRHSVLVRHLGDGTELRGRIVETEAYLGPEDQAAHSRGGRQTPRNRGMFMRPGTLYVYLIYGMYFCMNVSSRGDGACVLLRALEPLGGLEAMRQLRHTVRKGAASRALKDRELCSGPSKLCQALAIDKSFDQRDLATDEAVWLERGPSGSGEPAVVAAARVGIGHAGEWAQKPLRFYIQGSPWVSVVDRAAERDAQAGHRPAHEEF
The following text describes a protein:
Function:
Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.
Miscellaneous:
MISCELLANEOUS: Inhibited by aurintricarboxylic acid and Zn(2+).
Subcellular Localization:
Lysosome.
Sequence:
MTAQPLKAALPLLFVALSGVLGTPVISCINEDGKAVDWFAFYKLPRRTSRGGTGMGLDYLYLDSTMRTWSKSHHLINSSRSSLGRTLEQLYEAHNAKNDTAYLIYNDAVPASVNYSGNYGHAKGLLVWNRVQGFWLIHSIPKFPPVPEKGYEYPSSGRQYAQSGLCITLKYSQYETIDSQLLVFQPNIYSCFIPNIFRWELIHMPQMCAKSSASKIPSRRLTVLQSAQGLNFLHFAKSTFYTDDIFAAWIAQKLKVHLLVESWQRKNHELPSNCSLPYHVYNIKAIRGPLQSDFPSHHDHSKWCVSTKDSQARWTCIGDLNRSPHQALRSGGFICSKNRYIYQSFDRLVSHYASCN
The following text describes a protein:
Function:
Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MDQKSELVNSKFRVKKNVIIESTEENDDIRSHASSNADEHQKTLQFTALNSSYFTTDALPMMTYYKQTLTSRDTRRNRPTLQDLHEPRVGTNVEEGRVRKMEKSKSVDAGGTQPEGPSKFGWIQGVLIRCLLNIWGVMLFLRLSWVVGEAGIGFACLIILLAATVTTITTLSMSAICSNGEVKGGGAIGLVFSAANSIGVALYIVGFAESVKDYLKAINITLVDEINDVRIIGVIAATIVFAIAMSGVAWESKAQVILFVLLIAAILNCIVGSIMYSFIMPADKVARGFTGLSAATFLNNTAPKFSPTESFFTVFGVFFPAATGILAGANISANLKEPSKSIPIGTLLAILISTIAYLGLACLFGSAVERSTIFSSSNNTYSLNCTAGCRYGLRYDNQVASMISGWEPLTAAGIFAATISSALASMIGAPNILQAVGADRLFPYLEFFSVGNGERNEPRRGIALTYIVALIFIAIAELNYIAPIISNFFLIAYALINYSCFDASQARSPGWRPSFKFYSKWCSLVGALTCVAVMFVINWWAALITIAVVIGLYKYIDYSKPVVNWGSSGHARQYINALDAAYKLNTTVSHVKNFRPQCLVLCGIPSERLPLVKFASNFTNNYGLLICGNVMQEKSNTDMKDQYKILQENKIKAVVTTVTSTDFILGARALMQASGLGKLSPNMILFGFLENWQNRDDRIENYVAIIHDAFDLNFGVAIFRDRLEKEKGENNFDKNLQESGEGVRFCSNRTKEGNNLGGEVVDFGRGVLSHNKPGKSDSKLSNNFKELLKQPVEDKYVQLKEVRKIDSVIDIWWIYDDGGLTILIPYLLSLSKRWSNCKLRIFTPGKPEKLRDTMIGMTILLKKFRIEYENVIAVGDINEEPSEESMSRFCQSFPSLGHIFGNSDIENKTKIHIKLSELLIRHSMEASLVVITLPVPRKNFCPPSVYMSWLETISGPLPCPVLLVRGNQTSVLTFNS
The following text describes a protein:
Function:
Required for nicotinamide riboside transport across the inner membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKFLLHALDISGAIFAFFSTVFYVKADKWAWPIGAIATALNIVLYGLTGIYGDMTLEGIYFLSMFYGWYQWTRGSLAIGELPISNLSWRLAVILSVLAAGGIWGVAELLKHFTNSQVPYLDAVTTVLSLIAQWMICKKIIQTWFLWFIVDAIYVGLYLYKGIPAHSILLVIYLGLAVAGYLRWQKLMGAEKEMASFKLSKGFNYD