lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as component of the spliceosome (By similarity). Involved in modulating global transcription, probably acting via interaction with RNA polymerase II. Influences the chromatin distribution and phosphorylation state of RNA polymerase II subunit ama-1. Involved in regulating the germline sex determination pathway.
Subcellular Localization:
Nucleus. Chromosome. Nucleus, nuclear body. Note=Localized to nuclear chromatin (at protein level). Localization along chromatin is similar to that for RNA polymerase II subunit ama-1.
Sequence:
MYNGIGLQTARGSGTNGYVQSNLSHLMQARRKIEYNGEDDLRKMEAELNRKPNEEIMDHNRKRQIEVKCTEFEMLLEDKGLDDEDIERKVGEYRKNLLKQLESGELNVDEELSTKESHARRRAAANNRDKMRNALGLGEDYVPGSSMAKMNKSDVVGAAMESELPQKDDKEKLLETLRLHRKSKKKQESSSSSSSSSSSSESSSEDEKHRKDRKKKEKKQKLKEMEKRREKLRQKERELLAVSDKVKKEEPAESSDEEDSRKDQRKPREDRRRSVERQDQREDRRDRRRSPEDPRERRRSPEDRTVRRRSPERRRQQRSPSVERRKSPQRRDERRRRHDSSENERRSTATASKKSRMDELEVKQEPPSDSEDYIAKTNLAPIRVEKSAEKVEKSRKSSSESSSGSSDSDSSSDSSSSSDSSSDSE
The following text describes a protein:
Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKEDENAALGPDGQPLSKKALKKQAKEQEKAAKKSSRQSAEDASKQAGDTEVDYSEGHYGKMAMLQSSEKVSRELAKVKDLSSSIAGSYIWIRGRLHTSRSKGKQCFFVLRQQQYTVQCLVAVSEKVSKAMVKFCALVTKESLLDVYGIVQSSPQKVEGCTQQDIELHIEQLFVVSAAEPRLPLQVEDAARPENEDRRACSNLAFFPSCAAASEGGANVFEVSYFKGSAYLAQSPQLYKQMAIASDFDKVFTVGAVFRAEDSNTHRHLCEFVGLDLEMAFNYHYHEVLDIIGQMFVDIFKGLRDRYADEIAAVNRQFPAPPFKFLEPSLRLEFPEAVAMLRAAGVEMDDEEDLSTPNEKLLGRLVKAKYDTDFYILDKYPLKVRPFYTMPDPHNAKVSNSYDMFMRGEEILSGAQRIHDPTFLTERAKEHGVDVSKIKAYIDSFRYGVAPHAGGGIGLERVTMLYLGLDNIRKTSMFPRDPKRLTP
The following text describes a protein:
Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Miscellaneous:
MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLESHLIIYFLLAVIQFLLGIFTNGIIVVVNGIDLIKHRKMAPLDLLLSCLAVSRIFLQLFIFYVNVIVIFFIEFIMCSANCAILLFINELELWLATWLGVFYCAKVASVRHPLFXWLKMRISKLVPWMILGSLLYVSMICVFHSKYAGFMVPYFLRNFFSQNTTIQKEDTLAIQIFSFVAEFSVPLLIFLVAVLLLIFSLGRHTRQMRNTVAGSRVPGRGAPISALLSILSFLILYFSHCMIKVFLSSLKFHIRRFIFLFFILVIGIYPSGHSLILILGNPKLKQNAKKFLLHSKCCQ
The following text describes a protein:
Function:
Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
Miscellaneous:
MISCELLANEOUS: Inhibits intracellular mycobacterial growth by inducing apoptosis in infected macrophages. Induces macrophage apoptosis by triggering reactive oxygen species (ROS) production, release of cytochrome c, and activation of caspase-3 via a TLR4-dependent pathway. FbiA-mediated apoptosis may act as a host defense response; MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MKVTVLAGGVGGARFLLGVQQLLGLGQFAANSAHSDADHQLSAVVNVGDDAWIHGLRVCPDLDTCMYTLGGGVDPQRGWGQRDETWHAMQELVRYGVQPDWFELGDRDLATHLVRTQMLQAGYPLSQITEALCDRWQPGARLLPATDDRCETHVVITDPVDESRKAIHFQEWWVRYRAQVPTHSFAFVGAEKSSAATEAIAALADADIIMLAPSNPVVSIGAILAVPGIRAALREATAPIVGYSPIIGEKPLRGMADTCLSVIGVDSTAAAVGRHYGARCATGILDCWLVHDGDHAEIDGVTVRSVPLLMTDPNATAEMVRAGCDLAGVVA
The following text describes a protein:
Function:
Has antibacterial activity against Listeria and Enterococcus.
Subcellular Localization:
Secreted.
Sequence:
MNSVKELNVKEMKQLHGGVNYGNGVSCSKTKCSVNWGQAFQERYTAGINSFVSGVASGAGSIGRRP
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Unlike the case in E.coli, suppresses RecA-dependent homologous recombination, is instead required for single-strand annealing pathway repair of DSB; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MKLTDVDFAVEASGMVRAFNQAGVLDVSDVHVAQRLCALAGESDERVALAVAVAVRALRAGSVCVDLLSIARVAGHDDLPWPDPADWLAAVRASPLLADPPVLHLYDDRLLYLDRYWREEEQVCADLLALLTSRRPAGVPDLRRLFPTGFDEQRRAAEIALSQGVTVLTGGPGTGKTTTVARLLALVAEQAELAGEPRPRIALAAPTGKAAARLAEAVRREMAKLDATDRARLGDLHAVTLHRLLGAKPGARFRQDRQNRLPHNVIVVDETSMVSLTLMARLAEAVRPGARLILVGDADQLASVEAGAVLADLVDGFSVRDDALVAQLRTSHRFGKVIGTLAEAIRAGDGDAVLGLLRSGEERIEFVDDEDPAPRLRAVLVPHALRLREAALLGASDVALATLDEHRLLCAHRDGPTGVLHWNRRVQAWLAEETGQPPWTPWYAGRPLLVTANDYGLRVYNGDTGVVLAGPTGLRAVISGASGPLDVATGRLGDVETMHAMTIHKSQGSQVDEVTVLMPQEDSRLLTRELLYTAVTRAKRKVRVVGSEASVRAAIARRAVRASGLRMRLQSTGCG
The following text describes a protein:
Function:
ATP-dependent transporter of the ATP-binding cassette (ABC) family which transports various molecules including bioamines, neurotransmitters, metabolic intermediates and second messengers. In the eye, required for the transport of the eye red and brown pigment precursors, guanine and tryptophan, into pigment cell granules. Probably in association with bw/brown, involved in the transport of guanine. Probably in association with st/scarlet involved in the transport of kynurenine and probably tryptophan. Involved in the transport of kynurenine in pupal eyes. May play a role in histamine uptake by the lamina epithelial glia which surrounds photoreceptors R1-R6. In Malpighian tubules, involved in the transport of cGMP, guanine, xanthine, riboflavin, kynurenine and tryptophan. Probably in association with br/brown, involved in aging-induced intestinal stem cell proliferation in the midgut by regulating tetrahydrofolate transport. Probably in association with st/scarlet, plays a role in zinc storage granule biogenesis in Malpighian tubule principal epithelial cells.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Co-localizes with st/scarlet to pigment granules within pigment cells and retinula cells of the compound eye.
Sequence:
MGQEDQELLIRGGSKHPSAEHLNNGDSGAASQSCINQGFGQAKNYGTLLPPSPPEDSGSGSGQLAENLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALRLRARRKE
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
Sequence:
MATGVSSRDGSRERIRRRAVARDHPGCGPHRLDRPIGHIRYPHRHSISFSPFASLTLSHDPAPSQSVGKRPQKSTKTASRRKVETAAADAPRFINRELAWLEFNARVLDQADDPSVRLLERAKFLAITSSNLDEFMMVRVGSLKLQAVSGGGRRDPSGRTATEQLQAISKRCQGHVDRQYELLRNELLPLLGEHKINQVDPAECSDRLLAAAERHFRGDVLAVLSPQALHDRRFPMLPGLGIHLCVQLRPGDEIGPQRTPPPSDSLDNRVPSNLKRNSDTANQQPTPAENISAPEDGAEQTEPETQFAVIPLGRTLGRVIPLPIEKPPIEKGVAPKESDDTSPIESGYSYALLEDLVSHFVDEFFPGREVIQCKPFRITRNADIELREDGAGDLLGGMEEVLESRRLSDVVRLEIDANANSEIRDYLIKSFNVDPQFVFDIDGPLDLTYLFALHGLKGMNTLRDDEWPPQRSPRIDPAESMFTSISDGDIMLMHPYESFDPVVRLLEEASVDPDVLAVKQILYRTSRNSPIVAALMRAAERGKYVTAIVELKARFDEARNIEWAREMEQAGVQVIYGIRGLKTHAKVCIIVRREPQGLVRYVHFGTGNYNEVTANLYGDISVLTCDEILGTDATMFFNAVTGASQPQPLQQLGMAPLTLRRQILDLIQGETERSRQGQKGEIIAKMNALVDTEVIDSLYMASQAGVKIRLNVRGVCCLRPGVPGMSETIEVVSIVDRFLEHARTFYFRHGGDHEMFISSADWMPRNLDRRVELLVPVIDPAARKRLRETLQLYFRDNQNAWRMQPDGSYQRLKPRKNEAPMRVQETLYHQVVENRKAGKHAPQSTFETHRPD
The following text describes a protein:
Function:
Phosphorylates specifically NADH. Can phosphorylate NAD with a 100-fold decrease in efficiency compared to NADH. Prefers ATP as nucleoside triphosphate substrate. Can also utilize UTP, GTP and CTP. Key source of the cellular reductant NADPH which is an important antioxidant factor.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIRKLLLLLKPIDPYPFLQTEGASLIKNPQVLQYLESRCKVHKNAIKFCQEILSKKPVEWKPISRNDLSHPIRDVDMVITVGGDGTLLHASHFIDDSVPVLGVNSDPTQAHEVEELSDQFDASRSTGHLCAATVENFEQVLDDILFGRVVPAKVSRISLKLNSETLLSHALNDILIAQPCPAAVSRFSFKIKNKDGASSPKTVNCRSSGLRICTAAGSTAAMQSAGGFVMPMLSRDLQFMVREPISPGSTASLMHSTFKPDQFMDVNWYSDHGTIYIDGCQVQHSVQLGDTIEISSDAPVLNVFLSHGISQIRSRY
The following text describes a protein:
Function:
Precursor of the major egg-yolk proteins that are sources of nutrients during early development of oviparous organisms.
Miscellaneous:
MISCELLANEOUS: The serine-rich portion of vitellogenin encodes phosvitin (or two phosvettes). It is assumed to be phosphorylated to a level of about 80%.
Sequence:
MKGIVLALLLALAGSERTHIEPVFSESKISVYNYEAVILNGFPESGLSRAGIKINCKVEISAYAQRSYFLKIQSPEIKEYNGVWPKDPFTRSSKLTQALAEQLTKPARFEYSNGRVGDIFVADDVSDTVANIYRGILNLLQVTIKKSQDVYDLQESSVGGICHTRYVIQEDKRGDQIRIIKSTDFNNCQDKVSKTIGLELAEFCHSCKQLNRVIQGAATYTYKLKGRDQGTVIMEVTARQVLQVTPFAERHGAATMESRQVLAWVGSKSGQLTPPQIQLKNRGNLHYQFASELHQMPIHLMKTKSPEAQAVEVLQHLVQDTQQHIREDAPAKFLQLVQLLRASNFENLQALWKQFAQRTQYRRCLLDALPMAGTVDCLKFIKQLIHNEELTTQEAAVLITFAMRSARPGQRNFQISADLVQDSKVQKYSTVHKAAILAYGTMVRRYCDQLSSCPEHALEPLHELAAEAANKGHYEDIALALKALGNAGQPESIKRIQKFLPGFSSSADQLPVRIQTDAVMALRNIAKEDPRKVQEILLQIFMDRDVRTEVRMMACLALFETRPGLATVTAIANVAARESKTNLQLASFTFSQMKALSKSSVPHLEPLAAACSVALKILNPSLDNLGYRYSKVMRVDTFKYNLMAGAAAKVFIMNSANTMFPVFILAKFREYTSLVENDDIEIGIRGEGIEEFLRKQNIQFANFPMRKKISQIVKSLLGFKGLPSQVPLISGYIKLFGQEIAFTELNKEVIQNTIQALNQPAERHTMIRNVLNKLLNGVVGQYARRWMTWEYRHIIPTTVGLPAELSLYQSAIVHAAVNSDVKVKPTPSGDFSAAQLLESQIQLNGEVKPSVLVHTVATMGINSPLFQAGIEFHGKVHAHLPAKFTAFLDMKDRNFKIETPPFQQENHLVEIRAQTFAFTRNIADLDSARKTLVVPRNNEQNILKKHFETTGRTSAEGASMMEDSSEMGPKKYSAEPGHHQYAPNINSYDACTKFSKAGVHLCIQCKTHNAASRRNTIFYQAVGEHDFKLTMKPAHTEGAIEKLQLEITAGPKAASKIMGLVEVEGTEGEPMDETAVTKRLKMILGIDESRKDTNETALYRSKQKKKNKIHNRRLDAEVVEARKQQSSLSSSSSSSSSSSSSSSSSSSSSSSSSPSSSSSSSYSKRSKRREHNPHHQRESSSSSSQEQNKKRNLQENRKHGQKGMSSSSSSSSSSSSSSSSSSSSSSSSSSSSEENRPHKNRQHDNKQAKMQSNQHQQKKNKFSESSSSSSSSSSSEMWNKKKHHRNFYDLNFRRTARTKGTEHRGSRLSSSSESSSSSSESAYRHKAKFLGDKEPPVLVVTFKAVRNDNTKQGYQMVVYQEYHSSKQQIQAYVMDISKTRWAACFDAVVVNPHEAQASLKWGQNCQDYKINMKAETGNFGNQPALRVTANWPKIPSKWKSTGKVVGEYVPGAMYMMGFQGEYKRNSQRQVKLVFALSSPRTCDVVIRIPRLTVYYRALRLPVPIPVGHHAKENVLQTPTWNIFAEAPKLIMDSIQGECKVAQDQITTFNGVDLASALPENCYNVLAQDCSPEMKFMVLMRNSKESPNHKDINVKLGEYDIDMYYSADAFKMKINNLEVSEEHLPYKSFNYPTVEIKKKGNGVSLSASEYGIDSLDYDGLTFKFRPTIWMKGKTCGICGHNDDESEKELQMPDGSVAKDQMRFIHSWILPAESCSEGCNLKHTLVKLEKAIATDGAKAKCYSVQPVLRCAKGCSPVKTVEVSTGFHCLPSDVSLDLPEGQIRLEKSEDFSEKVEAHTACSCETSPCAA
The following text describes a protein:
Function:
Hydroxycinnamoyl transferase that catalyzes the transfer of an acyl from benzoyl-CoA to tryptamine, to produce benzoyl tryptamine. Serotonin and tyramine serve as acyl acceptors in vitro. Specific for benzoyl-CoA as acyl donor. Has no activity with p-coumaroyl-CoA, caffeoyl-CoA, or feruloyl-CoA as acyl donors.
Sequence:
MEITSSAMLKPAPTPTPHPLAGEKVPLTAFDRAAFDVFVPMVFAYRAPAPSSEAVKEGLRMAVAAYPLAAGRLAVDVAADGQGRRRRRRVLHVNDEGALVLDATVEADLDAVLAANVATDLYPAPPEHSFGAAVLQVQLTRFRCSGLVVGLIVHHHVFDGHSTSAFCTTWARAVRDGEAFSVPSPCLDRAITSVPRSPPAPVFDHRSIEFKVGNKSSDSSGAAAAAVEKITNIGVRFTAKFVAELKARVGGRCSTFECVLAHAWKKMTAARGLKPEEFTRVRVAVNCRRRANPPAPADLFGNMVLWAFPRLQVRRLLSASYRDVVGAIRAAVARVDGEYIQSFVDYVEVADARGEELAATAAEPGETLCPDLEVDSWLGFRFHEMDLGTGPPAAVLSPDLPIEGLMILVPVGGDGGGVDLFVALADDRAQVFEQICYSLEEHAIPSHL
The following text describes a protein:
Function:
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MSRCGSLGLYAPNALPSLSLKPRSVKSPFCITSHTKPNDTLLHNVNKMRAKACDILGAKKTILAAQLGAVLATIDHPALAITGVNNQQELSSVVLDIGIISVWYFLVMPPIIMNWLRVRWYRRKFFEMYLQFMFVFMFFPGLLLWAPFLNFRKFPRDPNMKNPWDKPTDPDSIKNVYLKYPYATPEDYDLD
The following text describes a protein:
Function:
Component of the menaquinol:cytochrome c reductase complex.
Miscellaneous:
MISCELLANEOUS: This cytochrome b is similar to other bacterial and plant chloroplast cytochrome b6 proteins in binding one of three hemes with a single thioether bond.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCFGGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVIVMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGLQIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQGISGPL
The following text describes a protein:
Function:
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPPRNTYEKGNPKRQNSPYYKPSFLRREETTNDEEKFQGHGLKTELHSALKSSNLNLIRRTYQTGENPYLSDPHDRGSSSRFNRRYERGLKFYQKGEISKRIAQERTLQKQQEEEELKRKLKQEEDEKDKRKLIESGDLPNLELHEDKFLLDLSKFKIYYDNNHGYEWWDTAYLDEKGELMEKYDMNGTSPAEEKLAEDIDEVDDDDDDEHPSIRYVAHPLPEKINEAKVSIKAYLTQHERKRLRRNRRKMAREAREIKIKLGLLPKPEPKVKLSNMMSVFENDQNITDPTAWEKVVKDQVDLRKRKHLEENERRHEDAIKRRKEAVNMNVEKPTVYHCKVFQFKNLQNPKIRFKLKMNSKELSLKGLCLRIRDDGPGIIIVVGNEKSCKFYENLVMKRIKWNEDFELHTNTGDIKMDMHNNSISKTWEGYLQDCKFKGWFMKVCNDQDSLLRTLGQFDSEHFYSPVQT
The following text describes a protein:
Function:
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Subcellular Localization:
Endomembrane system.
Sequence:
MSSNQSDYGPLPQAIGRALSDKMYEKRKGAALDIEKLVRDLAAKGDKDQIYKLTAVLGSDFALSPNTSLKRGGLIGLAATATGLGKESSGYVSELIRPVLPCFKDPDSRTRYLACEALYNIAKVTRNAILKHFNDVFNVLFVLAADPDINVKNGSELLDRLLKDIVTGSPNFDLNAFINLLRERIYTQNSFVGQFILSWVTTLDSVPDINMLVYLPEILDGLFHILSDQNKEVRKMCEFCLDEFLKGIRKNPSSADFPNMVNILTTHTTSQVELIQLTAMTWIREFLNLAGRSLLHFMSALLSAALPCLAYEDQKRKSIKEVATSVNQSLMRLVTQSDDDDTNQPPVSNTPEKTDLTHITLPVKLKLAPIVQVLTRYLGHKSIQTRIAVLQWIYHLHIKTPKKIFYHVEQLFPVILKTLSDPSDEVVLRDLEVLAEIVSSSAGPDFVADQQETNQIAPSAASNASFRAVTGTNKYFTDFMVKLLSLFSTDPQLLEDRGSFIIRQLCLLLNAEHIYQALSKILLDSPDMKFATTMVQTLNTILLTSTELFDLRNKLKDLRTEASCSLFCCLYKSWCHSPVATVSLCLLTQNYKHSCDLIYQFGDLEVTVDFLTEIDKLVQLIESPIFTYLRLQLLDAEHNPYLLKSLYGLLMLLPQSTAFNILHHRLTCVPNLQYLSGTGGAPKKLFLPGHKAAVGPSKGESSHKKNINWTQMLEHFHQIQEEHSKAKRSRHQPLENLASGRT
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MVLLESEQFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKGTVEGFEPADNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKTKKTKAAAAAAAAAPAAAATAATTAATAAATAAQ
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MARGVHAGAVSAGAGPGDAVGRELPRERWCGWSVLGGHPTRGQSGYPAGPRGLRAGAAPRAEAQAPPGGCLRKIGAPRSHPAAMCGSLGAGPLQRPQRCGCAGQGATGCGVNGVARSRQLLDSQIGFGLCVKGRVGTEERRWGPGGKGGLGVSKGAGPWLLWPPLTPSPRCWGPRASPLLTGLVSVAAEPGGGGGDLGQGNPPGAGKVRWGWNLLVPAPIPCPPRPLLPPPLPRSVGRSIGVSSRRDMRLSWVLTVLSICLSALATAAGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRSEL
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
MAIVLLRVRPVIFHSKCFNKKFHLDSVVRCLSATTLINNEARYSMEQMYTIVSQVEHYHEFVPWCKESLVSRGSSENSFDCRLTVGFPPLLERYNSRVTTIRPFEVKVEFQFKLSFHSQLTQLFFDEVIKKMVRAFFKRAETLYGPQSVKSERLKVVLHEES
The following text describes a protein:
Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Sequence:
MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVSGRLPCSFATLALLGSYTIQSELGDYDPELHGADYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKEKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVEPADRTPRPTSAPAIAPSPAAEGGVPGAPVKKAQKETVQVEVKQEEAPPEDAEPEPSEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKTITYEAAQTDDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
The following text describes a protein:
Function:
Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling; Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MYHLPAALRAGIGFLCLLLAGAAWAPPPNPTDPKFENKAALLTAREPDEFLCFTERLEDLVCFWEEAATAGVGPDNYSFSYQLEGEPWKPCRLHQAPTARGLVRFWCSLPTADTSSFVPLELHVTAASGASRYRRTIHVNEVVLLDPPARLVARRADEGGHVVLRWLPPPGAPMASLIRYEVNISAENAAGSAQRVEILDGRTECLLSNLRGGTRYTFMVRARMAEPSFGGFWSAWSEPASLLTASDLDPLILTLSLVLVLILLLLAVLALLSHRRTLKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQTDGCLWWSPSTPLPEDPPAPLEVLSECCWGVTQAVEPGADDGGPLLEPVGSEHAQDSYLVLDKWLLPRSPPSEDLLQPGGDMDIVTMDEASEASSCTSALALKPGPEGASATSFEYTILDPSSQLLRPRALPPELLPTPPHLKYLYLVVSDSGISTDYSSGGSQEAQGGSSNGPYSNPYENSLIPAPKPSPPSYVACS
The following text describes a protein:
Function:
Sesquiterpene synthase involved in germacrene A biosynthesis. Germacrene A is a precursor of several sesquiterpene lactones.
Sequence:
MSIQQEVNRPLRDIPLCVWGDQFLIYNKEPQQDEVDQIVHELKEKVRINIQAALAVPKEHTHLLKLIDAIQRLGISYYFEDEIDKALQHVYDAYGDDWNGGSPSLWFRLLRQHGFYVSCDVFNNYKDEQGAFKESLTRDVEELLELYEAAYMRVHGEVVLDEALSFTRAHLNKIAKDPIRCNSTMSIHIQEALDQPIRIRLPRLEALRYMRFYQQQASHDESLLKLAKLGFNLLQSLHKKELSELSRWWKDIDISNNLPYVRDRSVESYFWALGGYCEPKYSFARVFFTKFILVATILDDTYDSYGTYEELETLTEAILRWSVTCLDELTGYRKAVYQVLMDMYNEMEEILEKKGKIDIFNCSKEHVKTLVRGYLMEAKWAHEGYIPTTEEHDYVAFMTGSGGLLITSYYLGMADIVTNEAVKWAVTDPPLFKASTKVGRFLNDIAGHKQEQERNHFASTIESYKKQYDYTEEHVYDLMRKQVEDVWKDINLESLTCKDVPMPLIMVGVNLTRLLEVLYKGGDNFTYQGEQYKNHVKSLLVHAISI
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC26.
Sequence:
MDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER
The following text describes a protein:
Function:
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome.
Sequence:
MRGGFICSSDVTKCSSLMLAGRMSGPTFMSSGEVTEISRIHYDLEYMEGISQRMRIPETLKVGPESSAGRMQAQEPPPPHSTLMQVPERIVVAGDDGDLTFPRPRDLDLIQSVPPADLLNMKAPPNVLTLTEQPLDSLETDQTANAQRNSSNATSLHARARRERSDNVSSRHGNQISRGDVSVTSSPHAPPLRLCPPLYSPEDANINLFTAAGLLSYIQSTTRRAYQQVLEVLDDGHRRTHLDSTLDINPDESGLVDASSLRRQIVKLNRRLQLLEEENKERSKREMILYSATVAFWLINTWIWLRR
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
METTFVGICNMDLISQCHRLPNLGETIHGISLGHGFGGKAPNACAQFAFLSDENHKPNLLTSVGDDSDGKVCINHFKEIGISTDFVQVVKEIPTGCAICFVLDGGESAIIIHPNPVTIDMVHKMSEKLSHSKYVVTNFEIPVETALEVLKISRQGGAKTILNVSPLPEKKDINLFKDASIVILNEHELATFGKVEDFFEVGVEAVVCTKGPEGASVYEKGKPTVSVPSPKVKAVDTTGAGDSFLGAFSYCLSKGCSYEDAARIACVCASISVTALGAQGSYAHRDHKQLKDILPK
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Sequence:
MGDGALIVAVAIKGNNSKTKGVVRWALQEFASQEHVVFKLLHVQPRDSNSVSTTRKDLTTSVYKKDVDRKTREMLLPSRDMFVHREVQLDIMVLESDDIADAISKAVQDHGISELVIGASSSIIFSWKLKRSNLSSRIADATPRFCSVHVISKGKLLNVRKSDMDTETSIADDRSESRFSSDSHSGTVSSTSSHQFSSTPLLFQRIQALTTVNQKVGTNIGKQNNEPHHHHHNRAGSLDVDESKLLNQKGFYRTSSSGIGYGGSDISSWRSSQMEEASSSSTYSDPTSSSSQIHKDFELEKLKIELRHIKGMYAVAQSEVIDASKKMQDLNQRRSEEATRLKNLTIREEEADEVVEMERERQEDAENEAELVRECIERETEERLEAEARAEEVRKEKQRLEDALEGGPLQRQQYMKFEWEEIVEATSSFSDELKIGVGGYGSVYRCNLHHTTVAVKVLHSDKSSLTKQFHQELEILSKIRHPHLLLLLGACPERGSLVYEYMHNGSLEERLMKRRPNVDTPQPPPLRWFERFRIAWEIASALYFLHTNEPRPIVHRDLKPANILLDRNNVSKIGDVGLSKMVNLDPSHASTVFNETGPVGTFFYIDPEYQRTGVVTPESDIYAFGIILLQLVTARSAMGLAHSIEKALRDQTGKFTEILDKTAGDWPVKEAKEMVMIGLRCAEMRKRDRPDLGKEILPVLERLKEVASIARNMFADNLIDHHHNAPTHFYCPITKDVMENPCVASDGYTYEKRAIKEWLQKNHKSPMTDLPFPSDSLLPNHSLLSAIKEWRSQLIK