lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MSKELNENDKRKRNNLLSQYYGITEEKDVENLFDVDGKHFNADAYVDKLVQETSLKQLIDKEQELVREIQSLDSEMQTLVYENYNKFILATDTIRQMKSDFKTMEDEMEKLVQDMSHIATFANNISSNLQDRRQQITKLSNIHELLKNLQFLFDLPNKLKTCVEENNYSLAVKYYAKSEQVLQDFGDHPSFSGIQSDCKEIVETLRKCLKVQFSRAEVTSQELEESASLLCKLGESSTDLAREFLEINKVRLEKDLEDLSSYVWSGENNGEVVLIFIEKCCNTALNNVALTIATFNNIFPSTILKHNEGMNSMATDVINQLCPIVESKIVEIIGFEISEACCLSVVAALDKFHRRLLAVQRLLLVDKQWSFTLITEIARIISYRSANALVIKWTSELQGWRDSWNNDNQPHGSVKFIEGALVEHIHRAFVALTAFVGNHVTFSQDSQFRQTFGRRYVREEVLVLSLRKLSTMLANLSNVTGKDSASPTLILVLSRVAIDFSQNLAQSLLSLIEEQFDIPVGFQGDHLTPISVITLDFKQTSQSLLQSYVQSESHVLVQMIRKSMDSRDWLTASEPRSVRPVIKRVLEEISRVDSHAAQLYEEGSRKERSSDSSRRTHHSSSRMQQKSSWSSLGPSQLDSSLLNNIQKLFSERIDLSGTVEPNKGSVVMAIIKICLKGFLECVRLKTFGKYGIQQIQVDCYYLQLFLWRFTFDENLVHSLLDEILSSAVQRCLEPVLMEPGVVELICER
The following text describes a protein:
Function:
Transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MSSQHTELPETPDSGQESGQSRKSGDFPASKLNAEAPAFVPSMNSSPFWHGSSSRHLMPQVHHRQVLPFHPVHAHHGHFPYFGYGDQEHAGMATDPDPNPSKEVISEELSNKVVKQVEYYFRDANLATGDHLMKFVNKDSGGFVPISVIASFKKIKALISNHAMLADALRTSKKLVVSEDGKKVKRLHPLTESDIEDLQSRTVVVENLPEDHSHPNLEKIFSVVGSVKTIRICHPQGANGTASSAARSPKMDMLVSNKLHAFVEYETVEQAEKAVAELNDERNWRSGLRVRLLLRHTAKSEKPGRAKRADGNGEEDEASTSELLSEKHVDDQSPSPELSNDSIGDEGSHEREGGGRRSRGRGRGKARARGQHPNGWGTTMHSVGTPPTSSNNNHALTMPPPEPKHPPPGPRMPDGTRGFTMGRGKPMEIATQ
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNGIDIFLTLALPTVILIHLLLAPYTKVEESFNIQATHDILTYGLPTSNLSSTLNTYDHTAFPGAVPRTFFGALSLATVSKPILLLTRGRYAQVIVRGVLALFNAACLLRYRNGLTGAFGVDVGRWYMVLQVTQFHVVYYASRTLPNMFAFGLTTLAFTEFLPARGGSRPKVGIFLFVFAGVVFRSEIAILLFTQLVYLLVLSRISLKMVIPAGLQSAILALAISVPIDSYFWQEPLWPELAGFHYNAIQGKSSEWGTSPIFHYFISLLPRLLMNPLILLLLHPLALTIPATKHTSKDLIIPSLLFVAIYSLQPHKESRFIIYVVPPLTAAASLSASYIWTRRSKSWLYTFGSLVLIGSVALSFVASSAMLMISSLNYPGGDALSQLHNHILKDLSRSPRTQRTQDRNISIHMDVLSCMTGITRFQQYPSLPLRFPYNQNVTLNYDKTEDSPELGRSGFLDEVRLCIDGKNLVWRLASARF
The following text describes a protein:
Function:
Has anticoagulant activity, since it is able to inhibit the activation of coagulation factor X (F10) by coagulation factor VIIa (F7) (IC(50)=123.8 nM). Also shows weak irreversible neurotoxicity.
Subcellular Localization:
Secreted.
Sequence:
RLCLSDYSIFSETIEICPEGHNYCFKKFPKGITRLPWVIRGCAATCPKPEAQVYVDCCARDKCNR
The following text describes a protein:
Function:
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules.
Miscellaneous:
MISCELLANEOUS: The name 'dim gamma-tubulin 6' derives from the decreased gamma-tubulin staining of the spindle pole seen following RNAi-mediated knockdown of dgt6 in S2 cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=During mitosis, localizes at aster centers in prophase cells. In prometaphase and metaphase, associates with the entire spindle. During early anaphase, primarily detected on the kinetochore fibers undergoing anaphase shortening. In late anaphase and telophase, becomes enriched at the central spindle but is excluded from its middle region. In interphase cells, displays a uniform distribution. Enriched at spindle poles during meiosis in oocytes. During male meiosis, localizes to kinetochores in a microtubule-independent manner but does not concentrate on spindle microtubules.
Sequence:
MDRTIIAPWKAEEKEQSEKLHRKLQGLALVHPLPDELRKLIAWDMFLKPNQVAFVHVMHYLFRLLDPAEFKRRFFWPITDKKSEANFRSSTVEYLKHLNEKHQLHWANIKSYLVVMPGGMRFINFLLEFVGFVIQELIKQREKSLGLEAGTPNVSAKVMARQNAVMKEYASSYVVNLEENTALLRDKTQKIRRLMADLSADMGVPEEQLADDGFLDEFEATAALGVERVITQPTERKFDLEASLCGLKEAIDLFQVKQAENNQSKEAVEKALRGMRVLFDCDAVTEGDFYDPLGASKMDALLNGFNRISGTIAEQLDANDHYNESNAFVTTDLQALRVELSQSEVQLNNLLKKLNEPSKKDKGSANASGSARVQTLQPATPRFESVISSKFVSTPPIRIDMGGGGGRNAPVRLALQDDFNGKQFDALSNSLLAPAPPRSARKLKALDQSTGIDLNGTLNRSKINDPMQMLRTIHKNTSKVKAAPQANLSSLGSKWKQMQASFGFDEAPVPGAAVISPQTSPTDPSDPFTPLSGSECTRIERIPRTSENNTSLIAKSAAVIKVLEVSRNVLNLSTSPSGRLDALVPHTESHQQDVAPRLQLNDRTINDSLQLDPDFNIENDKNAFNVSHKFDFDQIGGEDDLQNISDSVLKDIIF
The following text describes a protein:
Function:
Transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis. Activates the expression of the genes encoding the fatty acid synthase (fas) and the 4-phosphopantetheinyl transferase (acpS), whose products are involved in the fatty acid and mycolic acid biosynthesis. Specifically binds to three conserved operator sequences present in the fas-acpS promoter region. Not essential for M.tuberculosis viability, although it is required for the optimal growth in vitro and for virulence in macrophages and in a mouse model of infection.
Domain:
Contains an N-terminal helix-turn-helix (HTH) DNA-binding domain and a larger C-terminal regulatory effector-binding domain (EBD). A long tunnel traverses the entire effector-binding domain, enabling long fatty acyl effectors to bind. When the tunnel is entirely occupied, the protein dimer adopts a rigid configuration with its DNA-binding domains in an open state, leading to DNA dissociation.
Sequence:
MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQLLVVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGVHQALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCIDAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWGGLSHVPLTRS
The following text describes a protein:
Function:
Developmental protein involved in oogenesis. Required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females. Also required for dorso-ventral and antero-posterior patterning of oocyte and eggshell. May be involved in microtubule function during oogenesis. Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers. Component of the RDC complex (rhi, del and cuff) which binds to repressive H3K9me3 marks in the piRNA clusters. RDC promotes the bidirectional transcription of piRNA clusters at these sites by interacting with Moonshiner which forms a complex with the transcription initiation factors TfIIA-S and Trf2. This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark. As part of the RDC complex, involved in suppression of splicing.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Colocalizes with the oocyte nucleus at midstages of oogenesis and with the centrosomes of early embryos. Expressed in nuclear foci. All components of the Rhino-Deadlock-Cutoff (RDC) Complex associate with these nuclear foci and are required for their formation.
Sequence:
MEKLDKIRMSQKLSCWQHILTTLGTSSKTEQEWNTFFKGFLESWRKPYCIQTSCDPSIPLRKELLVRPRKALQENPHGPGSTLPESPVFLEPINSTAPREHPSPSKSHSTGSTGCDPGNGERSPSVSNKNSKYKNPGNSKYAKIWKRSNNHTTSIFSKAQISKRRDKLSSTKKRPDTCAPTDDSRKNREPRACAPNKNIFKTRETNAPNLTKNSCALPNVLILSPNSASKITQRGHSVGQTQDYKASPGKIIKRVPRYSLQCLKKKTEKVHNKIMDKPKNKQQPQTPPPFLLNNEYTESSDDSDDQLPLSELSQKMKSNKLNTLFLSRNEDCSPAPEKVKLKGERPAQNKKEQLTWEPSILTNLTDLGKQVAEPLRKSVKKSAKQQKPRVRAPPQGKKTLPQLQTGLKTQDKQSTHEMISEQAKTISEASGQQTSQVQSSLSPNNIRNNSVKLISAKTLMPAQRSQDYSPNKMQVGQPLGFAIELPSPVDGKEASVEIDTQLVHTSKFLENMTRPSTVEVHKFDLMDIFMGENEKLDYEYDDDDVLSVAASWNGLDDENVPEDEPRKEAKTAEQLPKPEPSTETLKPIEKENAQKMQSIKSFQIPKLNAKNLKTQPSVMRSIYENEELEKNKVLAKPAPPSLVHQPLAESNRNQRDEATAARRAKETFPVFAPLYRVAPESAATLVSANSQQVIPQVYFSTSNQDGVNWIKDVFGIRCMQSVDNKCISINCDHTMNSLGEVQKRLMRMDEDTLLSLYRQTIRSFFLFQTYYTSFVDIFKFRNLWQYLLIMLVDCRLYKSISAPLLAHVYEALSKCGMQKEAVKRIMEHVWLPCKAHKYRDLMLTTLNILSNANWEDYCDKLTQLDKDYNFEIPHKNLITILKSSVDCSDKFANALKLITLHPNSIRTNETIMSILSNASKSYSYMHNESASASQGPPGAASFLAPPAAIQPPHTTVPNFGYLPNPSFHYSNEYAINIHNFD
The following text describes a protein:
Function:
Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Required for the anterograde transport of IFT88 (By similarity).
Subcellular Localization:
Cell projection, cilium.
Sequence:
MEKELRSTILFNAYKKEVFTTNTGYKSLQKRLRSNWKIQSLKDEITSEKLIGVKLWITAGPREKFTAAEFEVLKKYLDSGGDILVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVYYKYFHPKEALVSDGVLNREISRAAGKAVPGVIDEENSGNNAQALTFVYPFGATLSVMKPAVAVLSTGSVCFPLNRPILAFYHSKNQGFGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWLTTGDIHLNQIDAEDPEISDYTMVPDTATLSEQLRVCLQEGDENPRDFTTLFDLSIYQLDTTCLPKVIKAHEELNVKHEPLQLVQPQFEMPLPALQPAVFPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTDEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHIFFQVVEFKKLNQEAH
The following text describes a protein:
Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator.
Subcellular Localization:
Nucleus.
Sequence:
MAPSLQMLPDDTKAQLNDLKKNKIRKPVIEKMRRDRINHSIEQLRILLERNFQTHHPHSKLEKADILEMAVSYLQQQKKHQMNRSHLLPENVQDSYYQGYYMCLKETVGFLHTQENGHIQEENKNLTWNDSCLPAPYQSLYQQRVSLQVSPGSMKIWRPWQVLSPP
The following text describes a protein:
Function:
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence.
Subcellular Localization:
Nucleus.
Sequence:
MPETTQETCAPAKDSPFFIKNLLNCDSKPSKPRPVLAATKAALEGGFSLSQVGEFNFPRFELPAQRFSLPAHYLERTSAWWYPYTLSSGVHLHRTEVTERPGARDSSPTSGTDRDSPDLVLKTEPDAKEDEDDDEHNNNKSSDEIILEESDAEETKKEELEEWKKRDEDKKPCRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAAQRIVRVPILYHENSASEGGGAAANVPVSQPLLTFPHPSVYYSHPIVTSVPLLRPV
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Subcellular Localization:
Cell projection, ruffle membrane.
Sequence:
MDGKGIPKYPEAMGYHLTHIGENLQQAPGDPPRGVYEPPEVPVDQTWVVDPQCLANQDVPRILNASPDSLREHLHSKNLRDSQNNSTQVTFWAGILQAQMCVLDLEEELEKTDVFREELRRCIPSPMELPNFSPSGQASQDQSTGPRSLYMVDNSSQDSSGPEEDQREIQQDDPLGSPVEWGEEEESLFFDNPLFLESPTSVTGAPEESSWSLPVSDGEERTEHCRFESETQWSQRSLLEGRGGSWDPENKPESVVGVADPGKETDPLYLVPTYKLHYQSWVKQDCPSVPASVSSPLMIEDTLSVRKAPGVASGSPKSSFLGHSDAETARPPAPEPCVAPASFQEPDSPSIEVAGLSPLSSSCSSPGPSFNPSWNSSPLQPLEESLPQNTAFPEWRILATSCPSSLEKKGADLDSLKKTTEPLPLEKTVEPQEEVKPEEAGEAQQDVSPAPPSIKEHLQSTDPQTEPQGEEQRSEAKDKVANGINPDQMAWKLASSLYRLDGFRKSEVAAYLQKNNDFSKDVAEKYLSFFQFKDKSLDQALRGFLQALVLSGETQERERILYQFSKRFHHCNPGAFSSADAVHTLTCALMLLNTDLHGQNIGKSMTCQEFITNLNGLKDGGNFPKEQLKALYWSIRSEKLEWARKFSPLSKASVTYLDLVIYVRITFFTFLWIAPWGKRGWKMFHTLLRGMVLYFLKGEESCPENWYPDGPMPEEAVGVHHALAVPAVHYTKKPHVFQLRTADWRLYLFHAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRKFVRPILPTGPARSSLEEQHRSHESCLDAASDDLIDLQRNLPERKGRSRDLEEYRLRKEYLEYEKSRYETYVQLLVARLHCPSDDLDLWEDQLAQEAEGTWKPEPGLKKSHSSPSLHQEEAPTTAKVKRNISERRTYRKIIPKRNRNQL
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSKTEDKWEVVGNVKAKTRAQKQALSKSMPKADQLPYSVTQSPMFEGVNGRAFQDVSNKKPTKSDKVSAPKSPGKQAGKRPKKPQIENKFNYQSIEDAFKDEELFLIDDKLARLKEQFPNNEMVWLKDIASYLNINITCPEDNTDLTKQEFDYPICKASSATHQTLIRVFGKEVSEKVVPLIFQYCLTKMLECIARKNQMWGYKICLQAIAHTHPALCSDDLDIQVEKLKTSASEMQRCLALVWALGQVGLKDMRCGMKVWLQLLLPNLEKKKLAPYTMYYVERIVKKTKQNPAQSLSGCLNPGQFVEITRYATGNSQIKDRMSEVFPLFRQLIIHNNAMKRQFFNHFLTMSHVNEAVMGKMVEICMECLRDDAHCFTIWREKYSSSFPSSKLLLTELHNRRPGVLTEMPRVPFEDAVRYFRNINSEAATKSDSLTSKPEFATIRNICETLCDDFTEQRQTAQQSTKSFYFYLLLSMLIICGLFVLYDVKSHGTWKKSETYHFLKKNGVLDRTHQAWIKTKVYLDVAKKFVQTKAPIYWENSKLVLGPYLVKLTETGKLCWSWIVEVAKPVVFWISLKVNDGWIVLSSWLGNAASICLLYLDQLITYCWPYLVSFSDYMFEFYHWVLQVISGEASLAVVQDTFVQFCTNVANKVNLFIQNVFEIVSNYIAPNQP
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
Sequence:
MATIHVDGKEYDVNGADNLLQACLSLGLDIPYFCWHPALGSVGACRQCAVKQYQNADDTRGRLVMSCMTPATDGTFISIDDSEAKAFRESVVEWLMTNHPHDCPVCEEGGNCHLQDMTVMTGHSFRRYRFTKRTHQNQDLGPFISHEMNRCIACYRCVRYYKDYADGTDLGVYGAHDNVYFGRTESGTLESEFSGNLVEVCPTGVFTDKTHSERYNRKWDMQFAPSICQQCSVGCNTSPGERYGELRRIENRYNGSVNHYFMCDRGRFGYGYVNLKDRPRQPQQLRGSDWIHLNADQVMQGAADILRQAKKTIGIGSPRASLESNFALRELVGAENFYTGIAAGEQQRLQLMLKVLREGGIYTPALREIESYDAVLILGEDLTQTGARIALSVRQAVKGKAREMAAAQKVADWQIAAIMNIGQHAKHPLFITNVDNTRMDDIAAWNYRAPVDDQARLGFAIAHALDESAPAVADLDRSLKGKVDIIVQALAGAKKPLIITGSSAGSDAIIEAAANVAKALKNRGSDVGITFVASAANSIGLSMIGGGSLDQALELLTRGEADSAIVMENDLYRHAAKDKVDAALDNVANLIVVDHQRTAIMDKANLILSAASFAESDGTLVNQEGRAQRFFQVYDPTYYDDPKKPESRSIMLESWRWLHSLHSTYTSRHVDWTQLDHVIAACVEALPQLQGIVEAAPDATFRIRGQRLARSPHRYSGRTAMRADISVHEPRQPQDIDTPFSFSMEGNNSPLADRQQIPFAWAPGWNSPQAWNKFQAEVGGSLRFGDPGVRLIEAGEGTLDYFDSIPAAFTATAGNWQIAPYYHLFGSEEMSQRSDVIQQRMPTPYVMVNPADAAALGVNLGTLVEFNCAGQTLRLPVRLSDTLAPGQVGLPLGLPGIPPILVGARVEDLREAVQ
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSDKVKGKKQEEKDQSLRVQILVYRCMGIDLWSPTMANDRPWLTFVTMGPLFLFMVPMFLAAHEYITQVSLLSDTLGSTFASMLTLVKFLLFCYHRKEFVGLIYHIRAILAKEIEVWPDAREIIEVENQSDQMLSLTYTRCFGLAGIFAALKPFVGIILSSIRGDEIHLELPHNGVYPYDLQVVMFYVPTYLWNVMASYSAVTMALCVDSLLFFFTYNVCAIFKIAKHRMIHLPAVGGKEELEGLVQVLLLHQKGLQIADHIADKYRPLIFLQFFLSALQICFIGFQVADLFPNPQSLYFIAFVGSLLIALFIYSKCGENIKSASLDFGNGLYETNWTDFSPPTKRALLIAAMRAQRPCQMKGYFFEASMATFSTIVRSAVSYIMMLRSFNA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MPAEVCWTKGILSTTACIFPEHVKQVLLTGYPVAGMWRSAAQQLARQKLHGVRSGRIASNFPLLRQVTTSQSTAHQASASVQSLDRASESDRSSEFKSGLRFLKPSTSSSPSSLTPLDSAFIELVDLLPKCWQSTSTTDFNHDHSKLQTPLQVFDSRAYSSALEEDELCDEDIIGKENEHAREALPNGSNWDTGLDADSLLEQKSRKRKARELHKRQVKIETEAWQQAATEYRELMTEMCRKSLAPNLPFAQSLLLSWFEPLRDGILEEQRAYGNREHREHRSMYGPYMCQLPADMLAVITMHRLMGLLMCDQEHGCVKVIHAAVVIGEAVEQEVRIFQLMNSQKKSKDAEGNTNSLGDVANNEELEATRKADLKSKKVVRDKVKKLVKQNKLRRVDSILKHASTDEPWSTVIHVKLGSRLLELMLETSFVRAPACQDGDDFGELRPAFQHKFKNHVLRQNVNRIYGVIECDQLVLAEIDQSVKHMVMPYMPMLVKPLPWKGFNEGGYLYLKSSIMRTQGAKEQRMAVIDTPRKHMKVVVEALNVLGETGWRVNKRVLEVVEKLWKAGGGIADLVEADDVPIPERPDTSDKEVWHKWKVAVSQAKRTNSERHSLRCDTELKLGVANKLIDEEAFYYPHNLDFRGRAYPMHPHLNHLGNDLCRGLLIFADGKPLGPSGLRWIKIQLANLYGGSVGKMSFDDRAAFAEDRMEEILDSAERPLDGSRLWLKAEDPFQFLAACIDLRDALASGNPETFVSHLPVHQDGSCNGLQHYAALGRDRIGAESVNLIAGDKPADVYSGIAERVKIIMEKDALKNPLTSRNAASARLLQGQIDRKLVKQTVMTSVYGVTFIGARMQILNRLKERSPIAVDPVDTYRAACYAAKVTLDALGEMFKEARCIMSWLGDCAKIIAAAGHTVRWTSPLGLPIVQPYRKHSRHLVKTSLQVLALRNTDDNHPVLASRQRSAFPPNFVHSLDSSHMMMTALACSKAGLTFAGVHDSYWTHAGDVENMNVILRKNFVKLYKQPILENLLLDFQTQFPDLVFPEVPARGDLDLKEVLKSPYFFN
The following text describes a protein:
Function:
Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Contains LRR and Ig-domains that can mediate low-affinity interaction with EGFR. The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when both the LRRs and the Ig-domains are deleted.
Sequence:
MARPGPGVLGAPRLAPRLLLWLLLLLLQWPESAGAQAGPRAPCAAACTCAGDSLDCSGRGLATLPRDLPSWTRSLNLSYNRLSEIDSAAFEDLTNLQEVYLNSNELTAIPSLGAASIGVVSLFLQHNKILSVDGSQLKSYLSLEVLDLSSNNITEIRSSCFPNGLRIRELNLASNRISILESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISRLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSISRIQRDGWSFCQKLHELILSFNNLTRLDEESLAELSSLSILRLSHNAISHIAEGAFKGLKSLRVLDLDHNEISGTIEDTSGAFTGLDNLSKLTLFGNKIKSVAKRAFSGLESLEHLNLGENAIRSVQFDAFAKMKNLKELYISSESFLCDCQLKWLPPWLMGRMLQAFVTATCAHPESLKGQSIFSVLPDSFVCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSSPMTFAWKKDNEVLANADMENFAHVRAQDGEVMEYTTILHLRHVTFGHEGRYQCIITNHFGSTYSHKARLTVNVLPSFTKIPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVTVGETVAFQCKATGSPTPRITWLKGGRPLSLTERHHFTPGNQLLVVQNVMIDDAGRYTCEMSNPLGTERAHSQLSILPTPGCRKDGTTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETVVRTEGGHQANGHIESNGVCLRDPSLFPEVDIHSTTCRQPKLCVGYTREPWKVTEKADRTAAPHTTAHSGSAVCSDCSTDTAYHPQPVPRDSGQPGTASSQELRQHDREYSPHHPYSGTADGSHTLSGGSLYPSNHDRILPSLKNKAASADGNGDSSWTLAKLHEADCIDLKPSPTLASGSPELMEDAISTEAQHLLVSNGHLPKACDSSPESVPLKGQITGKRRGPLLLAPRS
The following text describes a protein:
Function:
Probable transporter of a GTP-driven Fe(2+) uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKKITVAVAGNPNVGKTTILNAIAGTALKVGNWPGVTVEKKEATVRYKDYEIHFVDLPGIYTLEPISEDEKIAVEFLEKGNVDVILTVLDSTNLERSLYLTVQLFEFEKPTVLVLNLYDEAQKLGIEIDEKAFYELLGVKAVKTVGKKGTGVEKILPLIVEAYEEKHVPRLKYSEELEEFLSEVAQKYKSLKAQPFTKHELIEFALRDKELQKKFKEKYGKEFKKYLEDERYAFAHGIYEEVVKQKGIDVRTLTDFLDNLLLHPVLGFVFFVVIMFLLFKVTFDFSSPFVDWVDGFFTDFLNPAVKEFLASLGAPEFISRFFSEAVIGGVGFVLTFVPLIFTLYFLITFLEMSGYVPRVAFLMDKFLHRMGLHGKSVIPLILALGCNVPAIVATRTLETTREKLIVIAMIPFISCPARLVVFSFFAITFFPNNAALVITGLYLLGVAVALLTAFLMRKSIARGASSHFVIELPPYRMPSLKTVLNISWIHVKDFLYRAGTLIFAASIFIWILLNLPPNVKNPKDSLAADIGRVLVPVFEPMGISDWRATTSLIPAFLAREIVLSSMGVIYTATEVVQEKEKFSFSEELKNQLSGLLEATKTAVKSVFSLKIQALEVEEEETGQLRDLIRNSFTPASAFAFMVFILIYTSCLGTYATMGREIGYGKATAFLVYSFVLAWIIGTISYKLLS
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Miscellaneous:
MISCELLANEOUS: Was named 'Organdy' because of the color of the translucid skin.
Sequence:
MTVLSQIIKPDDMIKITSEFARLGDRCYLDNAGATLYPKSLITSINEDLLKNVYMNPHTDKNTKDYIEQIRCLILKHFNTDPSTYTLIFTSGTTQALKLVIESFQFMKNEDDDLNCGSFVYLEDNHTSVVGLRELAVDKDAEVVHIAHEDFLNVINTKAKQTSKYTNGGNCLVAYPAQSNFNGFKYPLNCIENIKNGCLNNHLKKHLCEINSDWYVLLDAAAYVATSKLDLAKVQPDFVSLSFYKIFGFPTGLGALLVKKSSENVLSQKRYFGGGTVDALLSNEHYHIKREIFHERFEDGSLSFLSIISLKQCLDTMYRIIPRIIHDDIMETISYHTFYLAKDLYCQLLDLRHRNGTKAIKFYLDSDFSDITKQGGVLTFNLVREDGTYIGFSEFQHMADLFNISVRTGCFCNSGSCQRHLHMSNKDMKDMYNAGHRCGDEVDLINEKPTGAIRISFGYYNTFEDVDKFVNMICRCFVNAKARKQKRIINHFVETPKIKHYNGNVNKIINEQIYFKNVDDVLINIPPMSTKIILKEICIFPIKSCGAFKILSGWNIGPKGFEYDREWMIVKDNGVCLTQKQNTRMCMIRPQIDLKQKVMILNFPGKTPISIPLENSINEVQKNGSLCHSKVCTDMIKGIDCGDEVADWISEALEVSFLRLIRQSSNDNRSLKKKKDEDKKLLSLSNQAQYLLINKATVKWLSEKIKDPLFTDDLNHLTDRFRGNLIIEMEQELLEREWHSVIIGNHEFKVEGQCPRCQMVCIDQQTGEKTVEPLRTIAEQFGGKLRFGIYLSYVGTVNKSDDRTLKTYSPIKAILNDDNISR
The following text describes a protein:
Function:
May contribute to the transparency and refractive index of the lens.
Sequence:
LIRRPFFSWLAPSRIFDQIFGEHLPESELLPVSPSFSPFLMRSPILRMPSWL
The following text describes a protein:
Function:
Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips.
Subcellular Localization:
Cell projection, microvillus. Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
Sequence:
MYHESMNLPVLVGDLKYVINEPSRLPLFEAIRPLIPLKHQVEYDQLTPKRSRKLKEVRLDRLHPEGLGISVRGGVEFSCGLFISQLIKGGQADSVGLQIGDEIVRINGYSISSCTHEEVINLIRTKKIVSIKVRHVGMIPVKSSPDEPLKWQFVDQFISDPGEDKSSVAGLASSSGKSHKEKKVFISLIGTKGMGCSISSGPTQKPGIFISNIKPNSLSAEVGLEVGDQIVEVNGMDFSKIDHREAVKVLKSSQTLTISVVTGAGKELFMTEEERQREEYNREMERQELLRQKRLALETNKILKEQQEKEKLRKMEIAQKAAEEEERYRKEIEQIKAEEERFKKQWEEDWGHKEPPKPAKTVVADVHPPPRPKHRLDLDDNSLDQPAADDDLTGMKSEESQQGFQKYVENFDPYSVFSPDQLMGKDVRLLRIKKEGSLDLAVEGGVDSPIGKIVVSAIYEGGAADKHGGIVKGDEIMAVNGKILVNAKLDEAQATLAKAWIVGGDWIDLVIAVSPPKEYDDEMTFF
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MEDDYFSITSILADNHKMSCTFALDAEGLGYLEGSTENDIHEGTKVELPFWLAQTLSVNQFTTFTLPLPYSSRVQSALVASPVSVKLSNLVGGNGWWYRWGKKLADMLEDEQATNIRNMLLRAFTGRLPTLQDLAAHHASADHTMPELSTSKAEMFRDGMEGDERELFSIGQDSGRLFKAWYDRKKGSR
The following text describes a protein:
Function:
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MKHNYYILFLILISSLFLSNKVVESYGHRNNNKGGDSKILLKDVQVLTLRSGEMTKARRSSPIQQMECIGGTATKELELYPKTIQCYNMGSNGVDVQWKCEATLDSTVRLGTIDVSCEGYSYPEDPYITADSCGVFYQLEYTNEQRRKAALAEEETSWVQIIFCIAFIGLILYAVFNWCGSPQGDDDSNTAQNNTATDNNYPGGFPGNNNNNNNNNNNSNNNNYGGNYQGYPNLNNNNNAGGCAQPNNGGGGGGGWFQPGLWTGLASGYLFGRIHSNRNHHHYYNPSPSYNRPRSSYSSGSSGGSGISSSSSSYSGTSRR
The following text describes a protein:
Function:
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
Sequence:
MEQFNVWFTVSEVQGLVKSGGLADVAKALPQALKALHQQVAIALPAYRSVPGKEDAELVLETELTHWPHTQYRVLKRDLDGVPIYLIDCPAYFDRPALYAENNQAYADNGERFGFFSAACLDVLPKLGIQPDIIHANDWHTGLVPFLLKTRYRYDSFFEQVKSVLTVHNAIFKGIFSYHQLEVIPELNLSGMEFLQYGHDHVSMLRAGIAFADKVNAVSPNYAAELLTPLGAHGLVDDFVRRARDLHGIVNGCDYSEWNPRTDHYLPATYSDEPESMRKGKALCKTALQEELHLPVTDVPLFGMVCRLTHQKGFHYLLPILEQFLRNNVQVVIVGTGEPEVAARLNKIAHYHRAKFAFVETYSERLAHWVEAGSDFFLMPSEFEACGLNQIYSMAYGTLPIVREVGGLKDTVNDYDKFPERATGFGYQEPTPEALLITMQRALLFYLQQPEEMLKVQQRAMQQNFSWEESAQEYMKMYRLARFG