lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton.
Subcellular Localization:
Cytoplasm, cytosol. Membrane.
Sequence:
MYFLSGWPKRLLCPLKTVEKPFHIQPDSQRIFFSVLSQTQLSIWYSRPSVLIASYKESAKATAQFGNYKQAEWRPDSSMIVIATANGYILFFDIIPVGEDKYLYEPVYPKGSPHIKLNPHYKEEQCAPALNLETKKVMDLQASITSIQSMMEDLLVATEDGLLHIIHWEGMTNGRKAINLTTIPFSIDFQPSRAGSFLDFGDVHIRDMEYCATLDGFAVVFNDGRVGFITPGSNRLTADQIHGVWAPDVVDGTCVAVNNKYRLMAFGCVGGSVLVFTIDNTTGALQLSHKLELTPKQYPDMWNKTGAVKLIRWSPDCSVVMVTWECGGLSLWSVFGAHLICTLGGDFDYRADGTKKEALRICSMSWGTEGYHLWAITADSSQNTGYEMSDKSVPQQSGILQFQFIKSALTVNPCMSNQEQVLLQGEDRLYLNCGDATQTQNARNGSSQSEHKPLRDRSPFPGSSGNSQGLSTLLGHRHWHVVQIQSTYLQSNWPIRYTAIDKVGQNVAVVGKFGFAHYSLLTKKWKLFGNITQEQNMVVSGGLSWWKEFIVLACFNLSEQQEELRVYLRTSNLDNAFAHVIKVQLETLLLSIFRDMVIIFRADCSICLYSIERKKEGPNPSVCLQVLQEVSMSRYIPHPSLVVSVTLTSVRTETGISLKMPQQACDAESILLNLAGQLIMLQRDRSGPQIREKDAKTHQHKLLPFCAPVVLAQSVENVWSTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSKRIMLPFHINIYPLAVLFEDALVLGAINETVAYDCLNNLSTSSEHLEVHFPFCIVERTSQIYLHHILRQLLVRNLGEQALLLAQSCAALPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLETAASYLIILQNMEAAAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGEMETPPATPTTQEPSSTGGFEFFRHRSISLSQSAENFPSGKFNLQKTHSMPSGAAGKRWSKDSDCAENMYIDMMLWRHARRLLEEIRLKDLGGFAAQLGFELIGWLCKERTRAARVEDFVTSLKKLHKDFLWPFPVIPVASINSPFKNGKFRTAVGEQFLKSQSADGFLNMDVETPIPSAVRSHSWMGSLGTSQREMDSTSSHSPHTQDAFLSPLMNKADECSIGSATDLTETSSMVDGDWTMVDENFSTLSLTQSELEHISMELANKGPHKSQVQLRYLLHVFMEAGCLEWCVIIGLILRESSVINQVINLLQCPEVAEEMLQGIQSGLQAVDVWATTDCPGYKPFLNIIRPPLQKLSATTVEQVQTEAFQPTIPIKFTEQSSPCIEESRISTSHSISPQSDTSSVSGSRHEEDFSRQEKDETSQEGNYDCIVS
The following text describes a protein:
Function:
Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis.
Miscellaneous:
MISCELLANEOUS: Apparently encoded by an autosomal retrotransposed copy of the X-linked gene Utp14a. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNMARNVTDLLALSQQEELVDLPENYPLSTSEDEGDSDGEGKRQKLLEAVSSLGRKNKWKLAERSEASRMVSEFNVTSEGSGEKLVLSDLLGSATALSSVAAVKKQLHRVKSKTLTPPLNKEEADRALREAAFSKTSQMLSRWDPVVLKNRQAEQLIFPMEKEPPAVAPIEHVFTDWKVRTPLEQEVFNLLHKNKQPVTDPLLTPVETASIRAMSLEEAKIRRAELQRMRALQSYYEARARREKRIKSKKYHRALKKGKAKKALKEFEELWKDCPNAALQELEKMEKARMTERMSLKHQGSGKWAKSKAIMAKYDPEARKAMQEQLAKNRELTQKLQVVSESEEEDGCTEEGIVSVSHGMDDLQMNADGVNPWMLSSCNSNAKRGEIKTDPEQMPEFVAHVSSESEGDERPVAEELVLKERSFQERVDPNNAKLMDGQETEDSDSQEVLQKLNKESHQSDNQKVSSEENVLHIQREDLASEKLLVLQRLERAHVLEQQGELSKEEHYPKKGLSRPLLKGDWKEMKPLTNPDASGGKKKKEQMIDLRNLLTANSSPVRSLAVPTIQQLEDEVETDHKQLIREAFAGDDVIREFLKEKREAIETNKPKDLDLSLPGWGEWVGMGLKPSAKKRRRFLIKAPESSPRKDKNLPNVIISEKRNIHAAAHQVRALPHPFTHQQQFERTIQNPIGYMWNTQRTFQKLTVPKVGTKLGHIIKPIKAENVGYCSSTRSDLSILQSSQKCLSRKQQKQLKKLSSAD
The following text describes a protein:
Function:
Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEQPSIYNYSWVDFVFSVIGVFTFFVDWGADVWVATEFYRRGDFFWFGVLVGLMVLSSVLVQMFSWFWLQYDRGLPDLQTGGGTVLFGDRLRLSCLLHVLQLGFLCRHISAIRQGFRVWWRKEEGSEYAFYLSHDLSMLRLIETFSESAPQLTLMIYVMLRTQRARAVQFVSVAASTTSIAWMVVDYHRCLRSFLPDKARQGWASSLIYFLWNLLLIAPRVAALALFASVVGGYLGLHLLLLWLVFVTWAWLQRTHFMDSPGGEWLYRATVGIIWYFSWFNVAEGRTRGRSAIYHAFITADGAILLVTWWCCREPVQAEPYALALLLTLLLSYLLGLLFKSLYYCCFHPTLWRPPAREPGLPDDLPDADVTFRHLSIQDGAPASRPLNRRMALHAADFYSARTS
The following text describes a protein:
Function:
Acts downstream of daf-16/foxo to suppress tumors induced by disruption of gld-1. Potentially a direct target of daf-15/foxo.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MKSERVNYPVKLLNFILSIMNSYLFVLIVSIGFAESSSPKSSTSCSLMTSCAVEKCLDRGMVGRIITESSRDEVFGNLVEKFDMVCIAAKCGNECSQCKHCHYALEQMSALAQGEKTSGLCPKLETCVFNCLTEDVSKVLSCVATRCNVHCYDGDCPSCKMISRRIFSNICKQHSMTTQPQIKYEGTCPNLFMELADDYVAMKKKKL
The following text describes a protein:
Function:
Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
Sequence:
MGAALRGALRPCARAAVPGPRAYHGDRVSTLGTRPDPGSAVYQENYEQMRALVGQLHERAQRIRLGGGEKARARHRSRGKLLPRERVDGLLDPGSPFLELSQFAGYQLYGDEEVPAGGIITGIGRVSGVECMIVANDPTVKGGTYYPVTVKKHLRAQEIALQNRLPCIYLVDSGGANLPRQADVFPDRDHFGRIFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIFLGGPPLVKAATGEEVSAEDLGGADLHCRQSGVTDHYALDDNHALHLTRKIVRNLNYQKKLDVTVEPSEDPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFSEFKALYGDTLVTGFARIFGYPIGIIGNNGVLFSESAKKGAHFVQLCCQRKIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVSAVACANVPKMTIIIGGSYGAGNYGMCGRAYSPRFLYLWPNARVSVMGGEQAANVLATVAKDQRAREGKQFSSAEEAALKAPIMARFEEEGNPYYSSARLCCGFCRLLVKAQWRREGVAADLPHAAECALRRGPPGPRARSLDQPMAAGV
The following text describes a protein:
Function:
Membrane-bound O-acyltransferase that mediates the incorporation of unsaturated acyl chains into the sn-2 position of phospholipids.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MAYLIDIPFEYFSSFLGVHPDQLKLLFCFLSAYPFAGILKRLPSAPWIRNLFSISIGLFYLIGVHHLYDGVLVLLFDALFTYFVAAFYRSSRMPWIIFIVILGHTFSSHVIRYIYPSENTDITASQMVLCMKLTAFAWSVYDGRLPSSELSSYQKDRALRKIPNILYFLGYVFFFPSLLVGPAFDYVDYERFITLSMFKPLADPYEKQITPHSLEPALGRCWRGLLWLILFITGSSIYPLKFLLTPKFASSPILLKYGYVCITAFVARMKYYGAWELSDGACILSGIGYNGLDSSKHPRWDRVKNIDPIKFEFADNIKCALEAWNMNTNKWLRNYVYLRVAKKGKRPGFKSTLSTFTVSAMWHGVSAGYYLTFVSAAFIQTVAKYTRRHVRPFFLKPDMETPGPFKRVYDVIGMVATNLSLSYLIISFLLLNLKESIHVWKELYFIVHIYILIALAVFNSPIRSKLDNKIRSRVNSYKLKSYEQSMKSTSDTDMLNMSVPKREDFENDE
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MTRRREKAVQPVGTRRAAREFVFRVLFEADRGDVPLQAVFTRAEGVMREGDDTFPQLGPDALHFAEELVTGLERHREAIDDVLHRTIRGWTFDQMAQTDLNVLRLATYELMYTPEPHPPVIESAVRIARKFGGDDSGRFVNGVLAGLSRNLREEVGESPAADMTAPAPADTAPADTAPADPAASEPDEPRDA
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, Z line.
Sequence:
MHITQLNRECLLHLFSFLDKDSRKNLARTCPQLQDVFEDPTLWPLLHFRSLIELKKDNFLLSPALKNLSICWYSSRVQVCSIEDWLKSAFQRSICSRHESLVNDFLSQVCDRCPNLASVTLSGCGHVTDDCLARLLRCCPRLRALRLENCARVTNRTLAAVAAHGRALQTLHVDFCRNVSAAGLRRLRAACPRLALRAEHSAAMIPDQLPGVPATALRKLLPR
The following text describes a protein:
Function:
Regulates osmosis during embryonic development. Required for larval development and in particular is involved in larval molting.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Note=Co-localizes with ajm-1, an adherens junction marker in hypodermal cells and vulval toroids.
Sequence:
MSFPDEETDLLSEAKHCIRNVIHRTHRKFLENRLIGNFDSEDFSDAWKKKFAHAPTWCDADMSLQQIKRGKAVGNTVALTARAFFQLWLFRIGCFVQRWAWSTIFISLFLYCLCLGGLRHVTIETDLVKLWVSEGGRLNEEMGYLGQVKFERESGHLVHKVKRAVEQTTEPPAPAVKAEVRRGPELPKENGLGGGFQVVIQTPSFDGQNILSKEALQQHTKLMEEISTYEVKMFNETWTLSDICFKPPGPSFNSGPLAGIMSKLLDKIIPCIWITPIDCYWDGAKPLGPNPPLNLGPEVASFVSSLPPGNVTWKNLNPTSVIKEVGTLFDLGPIGNFFERAGIDGAYLDRPCIDPLEEECPKSAPNYFDRCHALTKFNEWNMAKAMSEQVTLERKIIPKDDGKSDIAETILNDIFGKKRRKRQADTTTKKPATKKDEDYYEYEDDADYLAGIANSTIAKKNPEKEAKDLLCLEYGSSLLKWMQENPERLGEFLTKEEMPDYPNYGDVMTGGCKGFGKKIMEWPEDLIIGGIQRDNGKLVSAEALQSVFLVSGAYDVFARIKNDKTDSHPGLDRHHFQPWMAGEIISTWQRNFTKRLYSHELNRERRQFHPLASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQGRFQGWWLAVQSNVALAICGVILVTISSICGLGFATHLGINFNAATTQVVPFLSLGLGIDDMFLLLHNYDEIINICNKNEIGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMFIFPAMIGIDLRRQRKGKRDLAYCSRGNPQMATSQSVPSNVSNMSSRAELAGYEKQADEYKRHEPWYTVGGFLNKIYIPALKNNVVKACVLIGTTTAVVFGLYGMYTSTLGLELADVLPEHTPPAAFLRAREQYFSFYPMFAVLRGDKLDIPNQQQLIEEYRAQLGSSKFMIKAEGKLQPYWMSMLRVWLQSLDMALEKDLAAGKFDLTNGNPIKVNGEKPSPESMIAARLVCSFGTNYNCDGRLGKMKMVENEVINPEGFYNYLTGWFNVDNMMYYVSQASFYPTPPGWEYNEKLAKVVPAAEPLLYSQMPFYQNDLIDTPAIVKMIEEIRATCEEYSERGLSNHPSGIAFTFWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTIELGGFMGLMGIKMNPISAVTLICAVGIGVEFTAHVELAFLTALGTIDQRLESCLQHMFVPVYHGAISTFLGVVMLVFSEFDFVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGPKPELTPTDGSSVLPPPPPLRQQYAEKSGGVEGGMRKRKEKRPAEVEMSARDSPSTSSASHSSDDESSPAHK
The following text describes a protein:
Function:
P granule component, which acts redundantly with P granule component meg-1 to promote P granule segregation during embryogenesis, and germ cell proliferation and differentiation in larval stages. Together with phosphorylated meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos. Together with dephosphorylated meg-1, promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos. Required for fertility.
Subcellular Localization:
Cytoplasmic granule. Note=Localizes to P granules in embryogenesis.
Sequence:
MENCDDLSSDENLPPPGDHRREQSQERARVGNRDESVSSTNMRSIGGAVHNQQQLYWTDMYNGSNNLENFWLCFSGNTSLADDPTVQSDSSASTQSRTNQSGTIAQETDNRNASNFPPRSTTRRGQTYESRDESQGGQAPSHQNQVPGVDRDEYAGDRSNVSINLPSVDQWREYSFSDNSFQGESRTVQRRSSRATHRVKNQFGSIGDGRTSNNTSLQEPVIQDTRNRNRSESSSTMSSQSRTEHAPIFRLQYNYQREADNRSSRLVQIQGHSAPNNANGLQNTGGQAPDIGPEVNGQSSDTRAMNMGNQMAQGDSHVPMNFVPRPLSNGVPRLHGVPRLVDMYDYELAQRAHARRYPTSNMPYGFPNAGFQAPPHMGLWPNNQNADTRAMNMDNRSRDRTFQMPPANAQVPTSSLSGLFNSSINHGSGNQQFQMGQSSSGSAPQLPALPENFLMAHANSQIPTSSLSGLFNAMNHGSGNRMNHSSSGPAPQLPNLPESFLMAHGIGQVETRSPAGPSNSSINHGSGNQQFPVQQSSSRPAPQLPNLPESFLMAHGLSQIQTSSTAGPSNSSMNHGSGNQQFRMGQSSSRPAPQLPSLQESFLMAHGIAQVETSSTAGPSNSSMNHGSGNQQFPVQQSSSRPAPHLPDLIRQEEEFLNTLEFEQFARRLYNDLLPGVDPNYDSGTSTSETPVLKFSITLKAMLYDYWRTMVQMQYRGANINFLQSIINLNARSAALNSSNARASGSADVQNQTVSATVEGADDASANVNALSDLLAQSFPRQAEGEASRRNDIDHPEDDLNQADSPKSDNQSDKDPPSN
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
Sequence:
MGTEKEEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATAGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWQEPAVNRDVQAAPEPSHPPKEPAPPSPESRLPRDLDLEVFCDSVEQLEPELVRVPVLSPVPAESELPHLHTGTGDSAQRVWAEQKEAAGRELTTRSSPESPEGFGGSLMGPQELDRWLVGTVQAMQESMKDVHRRLQILESKPQPLEQQRSPRTRPWPLGLSTPTLLFFILWPFVVQWLFRQFRTQRR
The following text describes a protein:
Function:
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Domain:
The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity); The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.
Sequence:
MPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPPSPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEVEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLLDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVANEADSIVGIISLSDILQALILTPAGAKQKETETE
The following text describes a protein:
Function:
Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression.
Sequence:
MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQTKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAAVWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVLDEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGILEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPALSAFLTHMRDHFQIKRPDQS
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MSRYLTPSKVALLSLISIYTEGVVPNSSAIHVLSFVVSYLSPLGAGDAPSSSDGWPAQYSVSIEDLEKALKVHPSSIPGRSIWDLFLRKIWSIDSCDALELFFTEISTTLAKTREERIRERDAGLAPESGCMRLARCSPLGAFVRRAQLEFTRLQFHDSVKLWKGFVKYRLPTYRAWARRNPSDEQVPVDINLLELGLDTSSHLAQVAYGNIEDNEEDDCYVSTKEVERLLEFQIGELQRFGGRVPEELKAQLKRIIASGVTLPDLIHYLSRDKGTYQYALLNLAILQADFGCYEEAVSAMQEAVSIARESHDMNCLNFCMSWLYHFGKAFPELITEVENTGMLGNEKEGLSFLKAKAKETEMWGLLSTTLLSEAKLELQNVLQPSTGYMFRANLAFTSGITHLAWLSSETFRHCYRSSAPFEDHLKSTFRSCQLAAHIIKLAQQGRYNEASAQMADMSLERFQSLKTVELPILSDDRESASQLLSQLRAIDLPDSDLSFLLSFITVEHLIRQADYAQALELIEKTAQSIHQDNFDIQPQVKLLCLKARIFEKMGQPQRGFSLAMRAASIAYRSRLLPGLWEAIVALGGVLLSLKEFEAVAKMVESIMPQVLETSDCDLAASAYSLLVDANMGIAGRLWSEGKDNGPAKKEYMNRALGYLDSAYEQYEEIEDLRGQCEMMAKKATVMHLTGDSVLANDYAAKYLDLRKQKTSSWI
The following text describes a protein:
Function:
GTPase-activating protein for the ADP ribosylation factor family.
Subcellular Localization:
Cytoplasm.
Sequence:
MGAVNSKAGEEGALYLRDQTRFSVASVNITNARNRTLLNITPNAFPATRYGARREFGDESVIDYIQDPESSSPSDGPPSFLIRLPNDEELTFNFTFIIRQHLAVPSIYNVNNASTIAPTGLVDTVINGLTFVFASSSKDLENLVTREFQANPNLHKNPQVELVGDYSTDGSTSVQFQWSWKWTPPKATESRGGGWRTSCSFVEYDQRAHKLETLANFAFWVQNLSVPPRLRVPSTQSIDSRVSDSADEGREWDNIPPKSPTFESIPENALALVPSQNTTLTSNSMPLRLDVSRPGEDLSQTEDGPLFRATMKSLEQKTGNMRTRWKKVLKRAESALEAQVNCNNAMSDLIDALKEASASNANAVQPAIDNYFDKIAKEILAYERTNTTNIQKSIIDPIHKLYNIDIKQAETKRKDFEEESKDYYQYLGRYLGQRTDSLKEKKRAETDSKYQTKRRNFELKRFDYSSFMQDLHGGRKDQDILSNLTRYADAQAKYYLDTAKKIDTMLPQLEALSLEVKEADKEFQIQRTEREEKRRALEKTKKTFEEPPVQQIASAVGVNGTAAKTSVNSEVDLPGRKANTGPSLSQHNKFKGIRDLEEKDLTAIPEGIHGAHRKEGLLWALSRPGSHVDPKGLNKQAWHKFWVVLDQGKLSEYTNWKQSLELHMEPIDLRMASVREARNADRRFCFEVITPQYTRVYQATNEDDMKSWINAVNNALQTAVETAGKSPSLSSHRNNYNSKAPARHATVGDRPSYGREPSNTGEEGKLLKQVRDAEPSNKVCADCGSEIKVDWVSINLGIIICIECSGIHRSLGTHITKVRSLTLDVTSFTPDIVEILLKIGNRISNLIWEARLDPAQKPGPMSTREQRLHFITAKYSDRAYVSPISPTMSHYNNPEDMLLASVKKNDIASVLYALALRASPDSRDRSRGTHVVFLALAAADPASPSASASPATSPGPAARPATPQPARKPFSVAELLLQNGAELPALPAPIPLTTSARSYLDFKTEQRAGKRLAPVALHNSSAELPSALPNIMAGNGSTPSERAREREARLQKRVSASGRLVKSPSSEASEGKRGF
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion.
Sequence:
MALTRDVKMPSDAELTVPQEITISTPYLKAVGPYMHMHCEAEIKVYMLRRRELEDPRATLKEGAAVTACGVRFLQSLKKNCAEQTKAFADCIDHGSSKLYVSKCRAEQAKMDQCVEEQLHIKRPALGYFSKPMVYESAKPRPVVVQRDYKAEAAKVIAELPEEYHLRSDYRNYRDWRYNVAVTCSVLPRGSTCQPAPFPRFRLV
The following text describes a protein:
Function:
Part of the plasmid partitioning system, which ensures the equal distribution of replicated plasmid molecules to daughter cells. The plasmids exist as well-organized plasmid foci within the nucleus that stay together throughout the cell-cycle and act as entity during segregation, effetively reducing copy number to one. Plasmid partitioning requires the proteins REP1, REP2, and a cis-acting locus STB (REP3). REP1-REP2 stably associate with CSE4-containing chromatin at STB during S-phase, marking the locus with a centromeric tag, and thereby probably catching mitotic spindle microtubules to the plasmid cluster and coupling plasmid segregation to chromosome segregation. REP1-REP2 are required to recruit the cohesin complex to the STB locus for pairing of the replicated plasmid cluster, a prerequisite for successful plasmid segregation. REP1-REP2 also negatively regulate expression of site-specific recombinase FLP and of RAF1.
Miscellaneous:
MISCELLANEOUS: The plasmid 2-micron circle is a extrachromosomal element that resides in the nucleus and propagates itself stably in host cell populations. It provides no obvious advantage to the host but imposes no significant disadvantage either at its steady-state copy number of 40-60 molecules/cell.
Subcellular Localization:
Nucleus. Note=Colocalizes with the STB locus of the 2-micron plasmid as foci in the nucleus near the spindle pole body. Is expelled from STB during a short interval between late G1 and early S phases.
Sequence:
MDDIETAKNLTVKARTAYSVWDVCRLFIEMIAPDVDIDIESKRKSDELLFPGYVIRPMESLTTGRPYGLDSSAEDSSVSSDSSAEVILPAAKMVKERFDSIGNGMLSSQEASQAAIDLMLQNNKLLDNRKQLYKSIAIIIGRLPEKDKKRATEMLMRKMDCTQLLVPPAPTEEDVMKLVSVVTQLLTLVPPDRQAALIGDLFIPESLKDIFNSFNELAAENRLQQKKSELEGRTEVNHANTNEEVPSRRTRSRDTNARGAYKLQNTITEGPKAVPTKKRRVATRVRGRKSRNTSRV
The following text describes a protein:
Function:
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor.
Miscellaneous:
MISCELLANEOUS: The MCR reaction has been shown to follow an ordered bi-bi ternary complex mechanism, in which methyl-SCoM must enter the MCR active site prior to CoB for a productive catalysis.
Subcellular Localization:
Cytoplasm. Note=Under growth limiting conditions on nickel-depleted media, a fraction of 70% of the enzyme is localized close to the cytoplasmic membrane, which implies 'facultative' membrane association of the enzyme.
Sequence:
MADKLFINALKKKFEESPEEKKTTFYTLGGWKQSERKTEFVNAGKEVAAKRGIPQYNPDIGTPLGQRVLMPYQVSTTDTYVEGDDLHFVNNAAMQQMWDDIRRTVIVGLNHAHAVIEKRLGKEVTPETITHYLETVNHAMPGAAVVQEHMVETHPALVADSYVKVFTGNDEIADEIDPAFVIDINKQFPEDQAETLKAEVGDGIWQVVRIPTIVSRTCDGATTSRWSAMQIGMSMISAYKQAAGEAATGDFAYAAKHAEVIHMGTYLPVRRARGENEPGGVPFGYLADICQSSRVNYEDPVRVSLDVVATGAMLYDQIWLGSYMSGGVGFTQYATAAYTDNILDDFTYFGKEYVEDKYGLCEAPNNMDTVLDVATEVTFYGLEQYEEYPALLEDQFGGSQRAAVVAAAAGCSTAFATGNAQTGLSGWYLSMYLHKEQHSRLGFYGYDLQDQCGASNVFSIRGDEGLPLELRGPNYPNYAMNVGHQGEYAGISQAPHAARGDAFVFNPLVKIAFADDNLVFDFTNVRGEFAKGALREFEPAGERALITPAK
The following text describes a protein:
Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
Subcellular Localization:
Nucleus.
Sequence:
MTTETFVKDVKPGLKNLSVLFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDELGNFIQPGDIIRLSKGFCMVYSEVPNFSEPNPEYIAQQSQSKQGQQESGTGTNNHNSSSPAPPASDLENGNGSNSSGPPAHQSTAPAHSASGRITRSQPNHSLPGAPNSVSNGKESRRTGKR
The following text describes a protein:
Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.
Subcellular Localization:
Secreted.
Sequence:
AVQKVDGEPRAHLGALLARYIQQARKAPSGRMSVIKNLQNLDPSHRISDRDYMGWMDF
The following text describes a protein:
Function:
Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MFRTVPKTTLLAPIQRRTLLNGNYPKAYPEHVPLTCLGRAVLAVGSGFGTFFDSRRGDLVATLGEATAQPYFIYKLREQMLKDPTGRRLLREQPRMTSKSLDLDKLRNMKVGSIGRTYVEWLDKEGVSPDTRAQVRYIDDPECAYVMQRYRESHDFYHALTGLPIIMEGELALKAFEWANTGLPMSGLGMVLTPLKFKPKQRKRYFDVYLPWALYNGFRSKPVINVYWEEVLEKDAEELRRDLGIEQPPDLRQMKKDMAKKK
The following text describes a protein:
Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MADDADGGDGEQLAPEADETNEAPALIMAKIEQRGKDVDALLRKQQVADALKTALADPPTNTRDENCKDANYAVMLKAIMSVKEVDPVLSQLSSKEADILMKYLYKGLASGEKAICDQCLRLHEKLTEKVGVGSIIRALGDSKHTV