lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MATFAKPENALKRAEELITVGQKQEALQALHDLITSRRYRAWQKTLERIMFKYVELCVDMRRGRFAKDGLIQYRIVCQQVNINSLEEVIKHFMHLATERAELARNQAQALEEALDVEDLEADKRPEDLMLSYVSGEKGKDRSDRELVTPWFKFLWETYRTVLEILRNNSRLEALYAMTAHRAFQFCKQYKRTTEFRRLCEIIRNHLANLNKYRDQRDRPDLSLPESLQLYLDTRFEQLKVATELSLWQEAFRSIEDIYGLMCMVKKTPKASLMGVYYGKLTEIFWMSSNHLYHAYAWLKLFSLQKGFNKNLSQKDLQLIASSVVLAALSVPPYDQSYGASHLELENEKERSLRVANLIGFEVEPKAENRVALSRSSLLSELVSKGVMSCVTQEVKDLYHLLENEFLPLDLALKVQPILNKISKLGGKLSSVSSVPEVQLSQYVPALEKLATLRLLQQVSQVYQTIQIDNISKMIPFFDFTAIEKISVDAVRRNFLAIKVDHMKGAVFFGKQSIEAEGLRDHLSLFAESLSKARTMIYPPAKKTAKLGDALSNLAEIVEKEHKRLLARKSIIEKRKEEQERLLLEMERVEESKRRELQKMTEDAEQKRIAAEYEQRRSQRILKEIEDRELEEAQAMLQEAEKRSKRKKKPILEGEKMTKQVIMELALNEQLRERQEREKKLQKYAKTMDHLERAKREEAAPLIEAAYKQRLAEEAALHEREQQQEVELSRQRHAGDLEEKKRLGRMLENKRILQERVVSSREAELNRLKQERRERISQIIQSRKQEREAKRKMLFFLRTEEERQKRLLEEEEARKREEAERRKKEEAERQAKLDEIAEKQRLRMIELEEKERREKEEILRRPAVLPRPSEPQALGRPTELGGAAPVPAAAAAAPAAGKYVPRHLRGNVDAAGQAPPPDTDRWGTGSKSDDRPSWRDERRPTSFGSSGSRTSWSSSRR
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
METQIVNFRDRYDNLALSVISNFVKFSQNVSNAREEEQRKLKYIEDLAKRIAETEAQMALVAAENLKVQEKKKKDLQKNAELRAKLKQETIKADDMQSAAQRERSRIEKEEQLSKNIQDKVNVFLKPYHDILGVTFQSSTGSEASLRLIFQMPNGKKCVVKLAKKGLKIVKCTPMLKDLEKLEAQLAKTNDYSGFVIHLRSLFMNEFTS
The following text describes a protein:
Function:
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MPDINELLRWSIANSTAPDTDASEQLQIRFNPNSTQSGTSTLHASDSGPPDISPASTPGPVTPDDGSSLPLPPGTEVPVTKKEDLTTEMLDLILGKGDSITMKEKMAFATDENNSVEDRVEALDDFEMLIELIDNANNMPILKLWDPLLTLLSSSHPEIVAHTCWIIGTAIQNNIKAQAAFYIHETFSRILEIIYPPSSISSYPPSVRAKATYALSAALKHWPLASYALYTATSSAENGYSVLRRGVNDPQAIVRRKMAFLVGTLAMQSGERYEGEIPSEVRNYIEENEKNAPSESLVEGLKREGVFTALVDGLKQGVDDVEYEENAMRALVRAHQKGGLTVSEKSDLKTIWEKWGKQGRQERGLDGEDGKEVSETLSS
The following text describes a protein:
Function:
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia. Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development (By similarity). Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ. Plays a role in ribosomal 40S subunit biogenesis. Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Microsome. Mitochondrion. Cell membrane; Lipid-anchor. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane.
Sequence:
MATSASSHLNKGIKQVYMALPQGDKVQAMYIWIDGTGEGLRCKTRTLDSEPKCIEELPEWNFDGSSTFQSEGSNSDMYLVPAAMFRDPFRKDPNKLVFCEVFKYNRKPAETNLRHTCKRIMDMVSNQRPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGIKIGGTNAEVMPAQWEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPFAVTEALIRTCLLNETGDEPFQYKN
The following text describes a protein:
Function:
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential).
Subcellular Localization:
Mitochondrion.
Sequence:
MMFQITKSKLRFPLSTFTKRYSSFQAAKSVIDKAAIDGELRVFIVSGEVSGDNIGSRLMSSLKKLSPLPIRFNGVGGSLMCKKGLNSLFPMEDLAVMGVWELLPHLYKFRVKLKETIDAAVKFKPHVVVTVDSKGFSFRLLKELRARYKQQRLENCSVHFHYVAPSFWAWKGGESRLGGLSEFVDHLFCILPNEERVCREHGVEATFVGHPVLEDASEFDLVRRCKPQELKLEGLSFSEHSIPSDSTVISVLPGSRLQEVERMLPIFSKAMKLLKDPFPKLVTLIHVASNNQVDHYIGESFSEWPVPAILVPSGSTQLKYDAFGASQAALCTSGTVAVELQLAHLPSLVAYRAHFLTELLIRYKAKIPYISLPNILLDSPIIPEALFQACNPSNLASILERLLLDEKMRERQVVGAEKLIQLLHPSESRMGNSIHCTGLESHRYTPSILAASTILSYARR
The following text describes a protein:
Function:
Acts as an endoplasmic reticulum (ER) membrane anchor for cytoplasmic proteins via binding to the FFAT motif of targeted proteins. Regulates phospholipid biosynthesis by modulating the subcellular localization of the transcriptional repressor OPI1. Also contributes to the tethering of the ER to the plasma membrane. Allows interorganelle phosphatidylserine (PtdSer) transport via a process that involves the acceptor membrane complex PDR17-PDS2 that binds to PBI1 which in turn ligates to SCS2 and phosphatidic acid present in the donor membrane, forming a zone of apposition that facilitates PtdSer transfer.
Miscellaneous:
MISCELLANEOUS: Present with 3497 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus membrane; Single-pass type IV membrane protein.
Domain:
The MSP domain is required for binding to the FFAT motif of target proteins.
Sequence:
MSAVEISPDVLVYKSPLTEQSTEYASISNNSDQTIAFKVKTTAPKFYCVRPNAAVVAPGETIQVQVIFLGLTEEPAADFKCRDKFLVITLPSPYDLNGKAVADVWSDLEAEFKQQAISKKIKVKYLISPDVHPAQNQNIQENKETVEPVVQDSEPKEVPAVVNEKEVPAEPETQPPVQVKKEEVPPVVQKTVPHENEKQTSNSTPAPQNQIKEAATVPAENESSSMGIFILVALLILVLGWFYR
The following text describes a protein:
Function:
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
Miscellaneous:
MISCELLANEOUS: It is phosphorylated in a PKA-dependent manner in vitro; MISCELLANEOUS: Present with 2340 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Mitochondrion. Chromosome. Note=Associates with the coding region of HTA1.
Domain:
The C-terminal repeats are critical for activity.
Sequence:
MSDNSDTNVSMQDHDQQFADPVVVPQSTDTKDENTSDKDTVDSGNVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQERNRFLDIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEASAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRERYGRSSSKQYRAAAQDGYVPQRFLLPSVDTATIWGVRCRPGKEKELIRKLLKKKFNLDRAMGKKKLKILSIFQRDNYTGRIYIEAPKQSVIEKFCNGVPDIYISQKLLIPVQELPLLLKPNKSDDVALEEGSYVRIKRGIYKGDLAMVDQISENNLEVMLKIVPRLDYGKFDEIDPTTQQRKSRRPTFAHRAPPQLFNPTMALRLDQANLYKRDDRHFTYKNEDYIDGYLYKSFRIQHVETKNIQPTVEELARFGSKEGAVDLTSVSQSIKKAQAAKVTFQPGDRIEVLNGEQRGSKGIVTRTTKDIATIKLNGFTTPLEFPISTLRKIFEPGDHVTVINGEHQGDAGLVLMVEQGQVTFMSTQTSREVTITANNLSKSIDTTATSSEYALHDIVELSAKNVACIIQAGHDIFKVIDETGKVSTITKGSILSKINTARARVSSVDANGNEIKIGDTIVEKVGSRREGQVLYIQTQQIFVVSKKIVENAGVFVVNPSNVEAVASKDNMLSNKMDLSKMNPEIISKMGPPSSKTFQQPIQSRGGREVALGKTVRIRSAGYKGQLGIVKDVNGDKATVELHSKNKHITIDKHKLTYYNREGGEGITYDELVNRRGRVPQARMGPSYVSAPRNMATGGIAAGAAATSSGLSGGMTPGWSSFDGGKTPAVNAHGGSGGGGVSSWGGASTWGGQGNGGASAWGGAGGGASAWGGQGTGATSTWGGASAWGNKSSWGGASTWASGGESNGAMSTWGGTGDRSAYGGASTWGGNNNNKSTRDGGASAWGNQDDGNRSAWNNQGNKSNYGGNSTWGGH
The following text describes a protein:
Function:
Plays an essential role in early steps of chloroplast development. Involved in the regulation of plastid gene expression. Required for the proper function of the plastid transcriptional machinery and protein accumulation in thylakoid membranes. May function as molecular chaperone to ensure proper organization of the nucleoids in chloroplasts.
Subcellular Localization:
Plastid, chloroplast. Plastid, chloroplast stroma, chloroplast nucleoid.
Sequence:
MLRLPTLLPLKPSPPTTGLNPIHGRRHGHHPSRLLASSAPPPPPPRPPKPEPRTSHENLGDDTPDFPTTKPRKPRRGRRSEAAAVEDFVRGRLEQVFASIRERDPEVLEGKGDILKRKEELSDEEGKEGTGEEEGELKAVVEEEDPSWPLDADIGWGIRASEYFDKHSIKNVTVDGVEIDWEREVEEGWVKEINCLEWESFAFHPSPLIVLVFERYNRAADNWKFLQELEKAAKVYWNSKDRLPPRTVKVDMNIERDLAFALQVKECPQLLFLRGNKILYREKELRTADELVQMIAHFYYNAKRPSCVNPEAIAPPC
The following text describes a protein:
Function:
BCL2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Acts close to the plasma membrane and targets several host TIR-domain containing adapter proteins including MYD88, TIRAP, TRIF and TICAM2. In turn, blocks the host NF-kappa-B and TRIF-mediated IRF3 activation.
Sequence:
MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALAEHISDSIPISELSRLRYNLCKYLRGHTESIEDKFDYFEDDDSSTCSAVTDRETDV
The following text describes a protein:
Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Subcellular Localization:
Cytoplasm. Mitochondrion inner membrane. Mitochondrion matrix.
Sequence:
MSTSIQVKSSNTGAARTYDDAIDALNSLQSNAATIEALRKSGGRLLDFAIPEMVEYLERIGYTTSDLNRLNVIHITGTKGKGSTCAFVDSLLGQLTPVNASAKPKVGLYTSPHMTSVRERIRINGQPVTHELFTKYFWQVWDRLSENPTRKFDLTPLRPVYFRFLTLLAFHIFLSEGVQPVILEVGIGGKYDSTNIVPKCVVAGITQLGLDHTAILGNTVEEIAVQKAGIFKPQAPAVCWAQQPGKALEQVKQVANQVGVSDLKIVNLHPAFQSDVDALGRSDVDTVSLGLPGFHQRTNASVALELVNTYLDSEAGRAMFKETSHRASTCQSDVLASWQKKGLEEARWPGRCQTVRSSLQELGLTWYLDGAHTTDSLGVCLEWFTTIQPRQAQSKRNRRIFVFNCTNGRSAHELLSSVLDTVEKSLAGDETGCQYRRAKDYFDEVIFTTNITFEGGGWSSELTSKLLDDKDLVNLTVQNQLAETWKQLVPESSTKVRITASIQAMHDHVMEVAREGQGVDCLVSGSLHLVGGVMAHLQHSGCLDDSLVSTVRA
The following text describes a protein:
Function:
Involved in RNA editing event in chloroplasts. Required for the editing of a single site in rps12 transcript.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAIFSTAQPLSLPRHPNFSNPNQPTTNNERSRHISLIERCVSLRQLKQTHGHMIRTGTFSDPYSASKLFAMAALSSFASLEYARKVFDEIPKPNSFAWNTLIRAYASGPDPVLSIWAFLDMVSESQCYPNKYTFPFLIKAAAEVSSLSLGQSLHGMAVKSAVGSDVFVANSLIHCYFSCGDLDSACKVFTTIKEKDVVSWNSMINGFVQKGSPDKALELFKKMESEDVKASHVTMVGVLSACAKIRNLEFGRQVCSYIEENRVNVNLTLANAMLDMYTKCGSIEDAKRLFDAMEEKDNVTWTTMLDGYAISEDYEAAREVLNSMPQKDIVAWNALISAYEQNGKPNEALIVFHELQLQKNMKLNQITLVSTLSACAQVGALELGRWIHSYIKKHGIRMNFHVTSALIHMYSKCGDLEKSREVFNSVEKRDVFVWSAMIGGLAMHGCGNEAVDMFYKMQEANVKPNGVTFTNVFCACSHTGLVDEAESLFHQMESNYGIVPEEKHYACIVDVLGRSGYLEKAVKFIEAMPIPPSTSVWGALLGACKIHANLNLAEMACTRLLELEPRNDGAHVLLSNIYAKLGKWENVSELRKHMRVTGLKKEPGCSSIEIDGMIHEFLSGDNAHPMSEKVYGKLHEVMEKLKSNGYEPEISQVLQIIEEEEMKEQSLNLHSEKLAICYGLISTEAPKVIRVIKNLRVCGDCHSVAKLISQLYDREIIVRDRYRFHHFRNGQCSCNDFW
The following text describes a protein:
Function:
The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAAQVPVQTIHRDPQLFYWILGPITVVMILTGMLRHYAAVLMAVAPKKVDAKAMREQRSLLHGINVRSNYHVLSKRSFNTRRDTLSSAYESGAFLKAPESRGQAPPNPMTDPNAMEGMMGMMKNNMAMIVPNTLIMSWINAFFSGYVIMKLPFPLTVKFKSMLQAGVATRDMDPRWMSSISWYFLCIFGLQFVFNFLLGSDNAANQMAQQMGQMGPQAPQMFGPGVDPDKQFLAEAENLAVIEHYSVLDDVEDRLLERLGA
The following text describes a protein:
Function:
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
Sequence:
MNAVIALRGLIVSCQAPEGSPLRDPTIIAAMAASACLNGAVAVRIESPEHIRAVRARVDVPIVGLWKRPYADSAVYITPTFGDAAAVAQSGADIVAIDATGRPRPGGESLAELIGRIHCELDRPVLADVATVAEGETAARLGADIVVTTLCGYTEATLGTPLPALDLVGALAGRLTVPVWCEGGVQSPEQVALAFARGARAVVVGTALTGLDARVRAFAERAVSPAVRTDPGTAFHNRANQSL
The following text describes a protein:
Function:
Required for male fertility and normal male germ cell differentiation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASAAGVVTSSEDSGRRKPRLAASLQISPGPSSRRPPASLGREPWEPVLAPSAEDDEGDGQSQASAGDGPARDFPTAAGQLSLQLKDPPPGQAVAVLEQYTAGLGVSLTFREDQTAGCCSSFSVCAEVDGVVCPAGTANSKLEAKQQAARSALRYIQSQLESPEPPEPPSRPPLAPLSVENILTHEQRCAAVVSAGFDRLVDRASLYQACKGTVAAVILEREVPGARGHTKEIYELVALGTGGSSCAGWLEFSGRQLHDCHGVVIARRALLRFLFRQLLLATQGGPKGKERSVLAPQPGPGPPFTLKPGIFLHLYVSNTPKGAAHDIYFPPSSKGSLLHSPPFRLQAHVRGELKPVCYVAPALRDTHVSCLSASDKLARWAVLGLGGALLAHFLPPLYATSLVLADPCHDPPTLSSAIHTRPSLESVLGPGLPRPYARTTLHLFSGPPVAPSDPTPNTCHGLSLNWSLGDPDIEVVDVATGRVKADAVLGPPSRLCKAAFLRAFRQAARALGKSHLLALKTYEAAKAGPYQEARRQLSLLLDQQGLGAWPSKPLVGKFRN
The following text describes a protein:
Function:
Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
Subcellular Localization:
Endomembrane system. Secreted.
Sequence:
MAARGGRALLALCGALAACGWLLGAGALEPGAPAAGVRRRRRLQQEDGISFEYHRYPELREALVAVWLQCTAVARIYTVGRSVEGRELLVIELSDRPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVKLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNLKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSCPDDAIFQSLARAYSSFNPPMSDPNRPPCRKNDDDSSFIDGTTNGAAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEESLRSYWEDNKNSLVRYLEQVSSLGRRVGLPRGAQPGATDLAWRARRGGRGRCWAAAGLAAPVLTIHREPLNAVCGRARARPVRVLLSPGPPAPHLGPVGRPGWEQHICAGPVAPGSPVPHLGPVGRLGRWQHSVCVCVCVCVCVWCCPGPPAPHLGPVGRPGWEQHVCAGPVTPGSPVPHLGPVGRLGRWQHSVCVCVCVCVCVCVWCCPGPSCLPSQACRAPPGGSSIACAPPAALAPPVPHLGPVGRPGWWQHSLCVSCCPSPSCPPSRACRVPPAGAGRRQGNEAPGLQALGGARGRGLWVEGPPRCEHLLKRCAPRAPLVSPSTQRDPRQSS
The following text describes a protein:
Function:
Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions. Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration.
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome. Midbody. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPRKKVTDGSGPGNGAARPANRKKAAASGKKRSRHEFSSDEDDLDGSPGSDGGFQGHNNKRGPAKGATKAPTAVIVTEPEHSKEKIKLEGSKAKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQILYNGQPITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFIEKTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLVKLFDFPGRGAAQIYAGATCSFAVSEMGGLFFWGATNTSRDSTMYPKAVQDLCGWKVRSLACGKSSIIVAADESTISWGPSPTFGELGYGDNKAKSSTTAQEVKTLDGIYSDQVIMGNSHTLVVARDETEQDKEKLKKLPEYNPRTL
The following text describes a protein:
Function:
Promotes both cell expansion and proliferation-dependent organ growth.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum.
Domain:
The OSR domain is sufficient to promote organ growth.
Sequence:
MYLLSPRNGDEEDEQEEIQELISDDEPPNLKLASCATAASSSSSSGSDMEKGRGKACGGGSTAPPPPPPSSSGKSGGGGGSNIREAAASGGGGGVWGKYFSVESLLLLVCVTASLVILPLVLPPLPPPPSMLMLVPVAMLVLLLALAFMPTTTSSSSSAGGGGGGGRNGATTGHAPYL
The following text describes a protein:
Function:
Regulates the expression of the dsdX-dsdA operon.
Sequence:
MEPLREIRNRLLNGWQLSKMHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLTHHFLMDEEILPVCSPEYAQRHALTNTVINLCHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDLAVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFIIWLREQVKTTS
The following text describes a protein:
Function:
Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
Subcellular Localization:
Secreted.
Domain:
Both EF-hands are required for function.
Sequence:
MLPLTMTVLILLLLPTGQAAPKDGVTRPDSEVQHQLLPNPFQPGQEQLGLLQSYLKGLGRTEVQLEHLSREQVLLYLFALHDYDQSGQLDGLELLSMLTAALAPGAANSPTTNPVILIVDKVLETQDLNGDGLMTPAELINFPGVALRHVEPGEPLAPSPQEPQAVGRQSLLAKSPLRQETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVHIVQVENDEI
The following text describes a protein:
Function:
Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool.
Subcellular Localization:
Secreted.
Sequence:
MQVRGREVSGLLISLTAVCLVVTPGSRACPRRCACYVPTEVHCTFRYLTSIPDGIPANVERINLGYNSLTRLTENDFDGLSKLELLMLHSNGIHRVSDKTFSGLQSLQVLKMSYNKVQIIRKDTFYGLGSLVRLHLDHNNIEFINPEAFYGLTSLRLVHLEGNRLTKLHPDTFVSLSYLQIFKTSFIKYLFLSDNFLTSLPKEMVSYMPNLESLYLHGNPWTCDCHLKWLSEWMQGNPDIIKCKKDRSSSSPQQCPLCMNPRISKGRPFAMVPSGAFLCTKPTIDPSLKSKSLVTQEDNGSASTSPQDFIEPFGSLSLNMTDLSGNKADMVCSIQKPSRTSPTAFTEENDYIMLNASFSTNLVCSVDYNHIQPVWQLLALYSDSPLILERKPQLTETPSLSSRYKQVALRPEDIFTSIEADVRADPFWFQQEKIVLQLNRTATTLSTLQIQFSTDAQIALPRAEMRAERLKWTMILMMNNPKLERTVLVGGTIALSCPGKGDPSPHLEWLLADGSKVRAPYVSEDGRILIDKNGKLELQMADSFDAGLYHCISTNDADADVLTYRITVVEPYGESTHDSGVQHTVVTGETLDLPCLSTGVPDASISWILPGNTVFSQPSRDRQILNNGTLRILQVTPKDQGHYQCVAANPSGADFSSFKVSVQKKGQRMVEHDREAGGSGLGEPNSSVSLKQPASLKLSASALTGSEAGKQVSGVHRKNKHRDLIHRRRGDSTLRRFREHRRQLPLSARRIDPQRWAALLEKAKKNSVPKKQENTTVKPVPLAVPLVELTDEEKDASGMIPPDEEFMVLKTKASGVPGRSPTADSGPVNHGFMTSIASGTEVSTVNPQTLQSEHLPDFKLFSVTNGTAVTKSMNPSIASKIEDTTNQNPIIIFPSVAEIRDSAQAGRASSQSAHPVTGGNMATYGHTNTYSSFTSKASTVLQPINPTESYGPQIPITGVSRPSSSDISSHTTADPSFSSHPSGSHTTASSLFHIPRNNNTGNFPLSRHLGRERTIWSRGRVKNPHRTPVLRRHRHRTVRPAIKGPANKNVSQVPATEYPGMCHTCPSAEGLTVATAALSVPSSSHSALPKTNNVGVIAEESTTVVKKPLLLFKDKQNVDIEIITTTTKYSGGESNHVIPTEASMTSAPTSVSLGKSPVDNSGHLSMPGTIQTGKDSVETTPLPSPLSTPSIPTSTKFSKRKTPLHQIFVNNQKKEGMLKNPYQFGLQKNPAAKLPKIAPLLPTGQSSPSDSTTLLTSPPPALSTTMAATQNKGTEVVSGARSLSAGKKQPFTNSSPVLPSTISKRSNTLNFLSTETPTVTSPTATASVIMSETQRTRSKEAKDQIKGPRKNRNNANTTPRQVSGYSAYSALTTADTPLAFSHSPRQDDGGNVSAVAYHSTTSLLAITELFEKYTQTLGNTTALETTLLSKSQESTTVKRASDTPPPLLSSGAPPVPTPSPPPFTKGVVTDSKVTSAFQMTSNRVVTIYESSRHNTDLQQPSAEASPNPEIITGTTDSPSNLFPSTSVPALRVDKPQNSKWKPSPWPEHKYQLKSYSETIEKGKRPAVSMSPHLSLPEASTHASHWNTQKHAEKSVFDKKPGQNPTSKHLPYVSLPKTLLKKPRIIGGKAASFTVPANSDVFLPCEAVGDPLPIIHWTRVSSGLEISQGTQKSRFHVLPNGTLSIQRVSIQDRGQYLCSAFNPLGVDHFHVSLSVVFYPARILDRHVKEITVHFGSTVELKCRVEGMPRPTVSWILANQTVVSETAKGSRKVWVTPDGTLIIYNLSLYDRGFYKCVASNPSGQDSLLVKIQVITAPPVIIEQKRQAIVGVLGGSLKLPCTAKGTPQPSVHWVLYDGTELKPLQLTHSRFFLYPNGTLYIRSIAPSVRGTYECIATSSSGSERRVVILTVEEGETIPRIETASQKWTEVNLGEKLLLNCSATGDPKPRIIWRLPSKAVIDQWHRMGSRIHVYPNGSLVVGSVTEKDAGDYLCVARNKMGDDLVLMHVRLRLTPAKIEQKQYFKKQVLHGKDFQVDCKASGSPVPEVSWSLPDGTVLNNVAQADDSGYRTKRYTLFHNGTLYFNNVGMAEEGDYICSAQNTLGKDEMKVHLTVLTAIPRIRQSYKTTMRLRAGETAVLDCEVTGEPKPNVFWLLPSNNVISFSNDRFTFHANRTLSIHKVKPLDSGDYVCVAQNPSGDDTKTYKLDIVSKPPLINGLYANKTVIKATAIRHSKKYFDCRADGIPSSQVTWIMPGNIFLPAPYFGSRVTVHPNGTLEMRNIRLSDSADFTCVVRSEGGESVLVVQLEVLEMLRRPTFRNPFNEKVIAQAGKPVALNCSVDGNPPPEITWILPDGTQFANRPHNSPYLMAGNGSLILYKATRNKSGKYRCAARNKVGYIEKLILLEIGQKPVILTYEPGMVKSVSGEPLSLHCVSDGIPKPNVKWTTPGGHVIDRPQVDGKYILHENGTLVIKATTAHDQGNYICRAQNSVGQAVISVSVMVVAYPPRIINYLPRNMLRRTGEAMQLHCVALGIPKPKVTWETPRHSLLSKATARKPHRSEMLHPQGTLVIQNLQTSDSGVYKCRAQNLLGTDYATTYIQVL
The following text describes a protein:
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPGPTPSGTNVGASGRSPSKAVAARTAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
The following text describes a protein:
Function:
May act in meiotic drive.
Miscellaneous:
MISCELLANEOUS: Although the gene is capable of encoding two isoforms, RNA sequencing data show no evidence of alternative transcripts.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNSNYVPLTSSVDVEEKMESENGVDLGNDIDLEKGLPLKYNSENESGLPSNSASSYLINPDPTMDLEAQTFNHNESTTSVGHDNSNSPPKCRKTCSSNKVYSNEVPLLFVFVISISIVCIFDLVIFGCLQYNMVSMDDLHVMQRLSWFCASLALLFILMRYYDFWTKACKDGIKHIFKKWKNTPLAFLQVLIFNIIGFFVRKGLKDSFGEQWGLKTSLFAHVSFATMSIFIFIFETLKPGSCSVDWIARILKAVVYFLEDSDEL
The following text describes a protein:
Function:
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MFNKPFRVKSNTPIKGSERKKLKAELQKCYPTITEEDLTLLIPNKEEMSVMKIETHGGEIVSAHVVGKKPIVFHIRDKLYPTIYLLWILPNKLIPYFTTWNEVVPKFSNGADLMLPGIIVKEEMGLRAYGRLNKGVTVAVNSNTNSAAVAVGMTALSSEDMYMAGRRGKGIEILHCIGDFLWQAGTKESPPELGTPGSQSDAKVTAPQDATANTEEGTEIAETKESVEQAPDMNQQPSSIVGDSAEAPAEQKNPQEAMDELLNYCFFKALKTSAKKIELPVLTSNFYRLHIVPACPSEKTLDVKKSSYKKLSKFLDTLKKEGVIDVKEFTKGVESISAIRYDHERVRSFRVDINDKPEPAPALEKVGEIDKYLPPVITRMYAINAVCLPLFAGTYRKGTNLTTQQIRQYLTEYVRVNQLQNATNPSQVTLDPILSDVMLKKGEVAASLSWEELMSRCQAKLSTVYEMIFPNQSAPVIVKGELEPVEITTASRAGNKKVTLISGLETYRIDLDEFARRCQVGVAASTTITSSPAKKGQLVLVQGNQISFVGNLLIDEYGIPKQFIQGFDLKKAKNKK
The following text describes a protein:
Function:
Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MSLPPEKASELKQLIHQQLSKMDVHGRIREILAETIREELAPDQQHLSTEDLIKALRRRGIIDDVMKELNFVTDSVDQELPSSPKQTVGFDKQSTLKKTNIDPARRYLYLQVLGGKAFLEHLQEPEPLPGQICSTFTLCLHYRNQRFRSKPVPCACEPDFHDGFLLEVHRESLGDGTRMADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTSLTVELMGVGTESKVSVGILNIKLEMYPPLSQTLSQEVVNTQLALERQKTAEKERLFLVYAKQWWREYLQIRPSHNSRLVKIFAQDENGINRPVCSYVKPLRAGRLLDTPRQAARFVNVLGYERAPVIGGGGKQEQWCTLLAFLCRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGAPHAWVMTCGTDGTIMFWESLTGHRYIHKPTNPDEPPLAEQPKPLYPYRTVGCVFNHQTFLGNCQPSDAVETCVFDLNDESKWKPMSEEAIKSVCAPGATTSLPPFPPLCASTIDASATSNEIEMQLRLLVSEHRKDLGLTTVWEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFVYRNARRAFATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACECAS