lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system is essential for its function. ATG12/ATG5 conjugate has an essential role in plant nutrient recycling.
Sequence:
RKFPPPSSFPRVRSPSAMAADPNHKKVVVNFQSVANAPKLRQSKFKIGGNEKFARVIEFLRRQIHQDTVFLYVNSAFSPNPDELISDLYSNFGIDGQLVVNYASSMAWG
The following text describes a protein:
Function:
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADDEGEEDPGINNMGNLLQVISSESEEEDDLEMEDPEVADGEAPNIINFDTSLPTSHTYLGVDMEEFHGRTLHDDDSCQQIPVLPNVQVMLIPGQTLPLHLSRPQEVSMVRGLIQRDRTFAVLAYSDGLEREARFGTTAEIYAYREEHEFGIETVKVKAIGRQRFQVLEMRNQADGIQLARVQILPEKVLPCPMTSLQLDSQSRHLLIPANKPASSRSPHSKCQWLHKYRRRKFLGASLTSWPSWLYALYDADSLMERVKLQLHEWDENLRDDSLPANPIDFSYRVAACLPIDDALRIQLLQIGNAIQRLRCELDIMSKCTSLCCKHCPDTEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKAFNLSLVGRPSTESSWFPGFAWTIAQCRVCGSHMGWKFTAVRKDLSPQKFWGLTRSALQPRIPEPDEGEEGHDHSPILCL
The following text describes a protein:
Function:
Probably participates in a plant defense mechanism. Has anti-HIV activity.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
GFPCGESCVFIPCISAAIGCSCKNKVCYRN
The following text describes a protein:
Function:
Involved in chromosome segregation. Facilitates nuclear oscillation during meiotic prophase I, the 'horsetail' phase, by acting as a dynein anchor. Essential for anchoring dhc1 to the cortex. Required for proper sliding of the microtubules along the cell cortex, which leads to the proper U-turn movement of the nucleus.
Subcellular Localization:
Cytoplasm, cell cortex. Note=Localizes to the cell cortex during the 'horsetail' phase of mitosis.
Sequence:
MEKKQDNEVELYSIDLKNRNESAKIKLAYAKALEESILCETRKIEQEIKDQVVQKENKTYFNNKFDNRYKLRDLEKNLAEEEVRITEMLTIQRQDIAIERRKNTNCFSESSQVDQYSVTETNLQYATNIGLNLLQQLRYLRLQLSEKEDLHKKLSVDNAHLIKQLDLLSSNMKTLMKEKTKVQGQRDLLEQRLQGLMKKLTEVESLTVSLNDEKNKLTLELTNLRICLHELQLNAEKGETIDESEDSKNTLVTEDENDDSVFLESSSDKYFDSSSFDAEQEEKHDFPIDPFLSLESNVQTSVSQSSAVLKSINLAKQELVSVNHLVADDTKTPSPNLSSEIIENTKADIKKSIRSLNKAVSPENSIDIEDETDRDDEFICFLLSYQQLQKALKSNLGLFQLSCLYPLSLNHLIQSFFQSLTSQISIKDIDSKNKQVIKLFKPTKSSDRQEIFELAQFEPRQKFPIDTNSSKCDMSASTEMHLKDTEKFANFKLKENILNHSSIYERDVSYLPALNKGGRENYLNNRVSSYRLVKPILNSYGNHVLNRIQHDILENHFCCLKNVKDFVCGANTISMQWNLQKNMEFISSVFSLIKNEVNDTSANSVILRTDALSNVATTRLKRKLTSAIIDCSIPRRRLRHYSNPEIAEFKNFRLSTDISHSNVRNSKKLCSNGSMNCMRQGKAVFPRKIPYQEHDWEQWEKIAQSSMFKNRSIASRQSLETSDVTLDINMSSRHSNGTSSMLFKDFTKHNNWEASTYPSAPKNTRTYPTAEVEKTRHDSSQSARQLKARSTATTISISLSTVSDVFTLPRNNLKSKTNTKKCRDNLNLSGLSSSTCNANSVNKLMKHVMMGNEMMKYPRSESFKMFKKSHWRYFWINPHCEMLCWSKTNPFIEKGRKNQVKSVKIKGMTIIKAPDALKNANLHNEVIVMQTTDKPIVLKAKSKKIHNIWVQAIKQINHKAIFDTKPGI
The following text describes a protein:
Function:
Catalyzes the ATP or GTP-dependent addition of one L-glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin.
Sequence:
MKKIGIAITDPEDWTARALITAAKEKGFFPFILDLRIAEVSISSKTSEPATLFKAGEILLSDLDALIVRDVGAGAFEGVSFRFDILRELEAGGVTVMNSPEAIQNAANKYHASYLLARAGLPVPETVAVQSVEAALRAASGFGDAVIKPVFGYKGKDIARVKDGEIRFSDRKTGPGTVEEILEKLLEERGMLYIQEFIENPGRDIRAFVVGGKAIGAIYRKAAAGSWVNNLSRGGSADRCVLAEEQKEIAEKAALAVGTTFAGIDIIEGAKAQTGNENKKTEDKSTGQGSRILEVNGTPSGKGIFDAWGINPAEYILEYLQNIL
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MTTFDGDTSAGEAVDLTEANAFQDAAAPAEEVDPAAALKAELRSKPGDWYVVHSYAGYENKVKANLETRVQNLDVGDYIFQVEVPTEEVTEIKNGQRKQVNRKVLPGYILVRMDLTDDSWAAVRNTPGVTGFVGATSRPSALALDDVVKFLLPRGSTRKAAKGAASTAAAAEAGGLERPVVEVDYEVGESVTVMDGPFATLPATISEVNAEQQKLKVLVSIFGRETPVELTFGQVSKI
The following text describes a protein:
Function:
Metalloprotease which cleaves a single amino acid from the C-terminal end of polypeptide chains. Shows a strong preference for peptides with a terminal lysine residue.
Subcellular Localization:
Secreted.
Sequence:
MKFLLVLALCAVVYAKHEAYIGWKSYYVGVATDAQAKALEPLIQKYELDFLSHPTKSREGVVLVKPQHQAGFVQDIEAGGITYRIHADDVKRQLEFDDQLIEMQRMSSFTRTAGRQLPYDNYQELEVIDEYLDYIGEKYPDVATVVNAAESFEGRPIKYIKISTTNFEDENKPVIFIDGGIHAREWISPPSVTWAIHKLVEDVTENDLLEKFDWILLPVVNPDGYKYTFTNERFWRKTRSTNNNPLSQICRGADGNRNFDFVWNSIGTSNSPCSDIYAGTSAFSEVETRVVRDILHEHLARMALYLTMHSFGSMILYPWGHDGSLSQNALGLHTVGVAMASVIQSNALPNFPPYTVGNSALVIGYYIAGSSEDYAHSIGVPLSYTYELPGLSSGWDGFHLPPQYIEQVCRETWEGIVVGARRAGDLFRK
The following text describes a protein:
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSATAPIRIAARAQPAKYAFIIFHGLGDSGAGWTFLAEYLQRDPALASAQFVFPTAPVRPITANNFAPATAWLDVRSWLSHESVDLEGFNESMKLVPKLIEEQVAQGIPYERIWIGGFSQGAALTMGTALSFPHRLGGFLSFSGPPSYRWLEHTVSDANTGAPVFQSHGTMDEVFPSSGAEAVHRSFTSQYGFKNHRLKIYDGLGHSISPQLLDDALAFIKANLDAEKPAPRPAL
The following text describes a protein:
Function:
Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. In vitro, the incision activity of Cho is UvrA and UvrB dependent. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair.
Sequence:
MVRRLTSPRLEFEAAAIYEYPEHLRSFLNDLPTRPGVYLFHGESDTMPLYIGKSVNIRSRVLSHLRTPDEAAMLRQSRRISWICTAGEIGALLLEARLIKEQQPLFNKRLRRNRQLCALQLNEKRVDVVYAKEVDFSRAPNLFGLFANRRAALQALQTIADEQKLCYGLLGLEPLSRGRACFRSALKRCAGACCGKESHEEHALRLRQSLERLRVVCWPWQGAVALKEQHPEMTQYHIIQNWLWLGAVNSLEEATTLIRTPAGFDHDGYKILCKPLLSGNYEITELDPANDQRAS
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKEQFYPLGIFLAAMLGGLVRYLVSTWLPASPDFPWGTLFVNYLGIFCLIFLVKGYLVYKGTSKGLILALGTGFCGGLTTFSSLMLDTVKLLDTGRYFSLVLYLLLSIGGGLLLAYFLGRKKW
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAKKNSQLPSTSEQILERSTTGATFLMMGQLFTKLVTFILNNLLIRFLSPRIFGITAFLEFIQGTVLFFSRDAIRLSTLRISDSGNGIIDDDDEEEYQETHYKSKVLQTAVNFAYIPFWIGFPLSIGLIAWQYRNINAYFITLPFFRWSIFLIWLSIIVELLSEPFFIVNQFMLNYAARSRFESIAVTTGCIVNFIVVYAVQQSRYPMGVVTSDIDKEGIAILAFALGKLAHSITLLACYYWDYLKNFKPKKLFSTRLTKIKTRENNELKKGYPKSTSYFFQNDILQHFKKVYFQLCFKHLLTEGDKLIINSLCTVEEQGIYALLSNYGSLLTRLLFAPIEESLRLFLARLLSSHNPKNLKLSIEVLVNLTRFYIYLSLMIIVFGPANSSFLLQFLIGSKWSTTSVLDTIRVYCFYIPFLSLNGIFEAFFQSVATGDQILKHSYFMMAFSGIFLLNSWLLIEKLKLSIEGLILSNIINMVLRILYCGVFLNKFHRELFTDSSFFFNFKDFKTVIIAGSTICLLDWWFIGYVKNLQQFVVNVLFAMGLLALILVKERQTIQSFINKRAVSNSKDV
The following text describes a protein:
Function:
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Sequence:
MARICVALDVPWERAIKIVKDLYDFFETYPLILKIGHKIYLEKGGDAVKELKEDFPYEVFLDLKLHDIPSVVGLAVEKISELGTDYTTVHLLGGPEMVKEAVKNKGSMKILGVTILTSHDENYIKFLKSNFEDIKNFTLYLARVGIENGVDGVVCSGEEVEFLKKNIEKDFIAVVPGIRIKKEKRHDQKRVLTPAEAKKRGADVIVIGREITESKNPVYVVERALKMMGEI
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSSSRELQYLEYTYRNNRPTTGLLNSIFMTTVNTAARSLVSVASTASTPEIPSRRWSASDHLSFASGLLTTAAENALVPAKASSSSSTSSTALVKYSGSSDLGMMICDGVDEPSVNSLGRALCHALALMNEIPVTSRKYQFAMGMAEKIMEDNAQSGHVDLLDVNRAALASSFARTTARLQDCLKRSRTADEPFGGLPLRVVSALPLGGYVASYVRGLSACINTVRSLADMTGNLLSQTRRRESAVVRAGGIQENEAELAVEKLAEELLWMTEKLRRYGAVAEGIKRWSYASGLASLSLTAAPRVQGLMVKISALLIGELARDSTQVPGQVTFRLLANWLPLFSHARNGLAFPVLTGYERVEVERAIDKAISTLPALDQEILLTNWLQDFSVSASEWPNLQPAYDRWCHSTRQLFM
The following text describes a protein:
Function:
Binds to host erythrocytes.
Miscellaneous:
MISCELLANEOUS: Vaccinations with the recombinant proteins derived from Rouen 1987/Rouen87 or Weybridge 8843/W8843 strains protect gerbils against heterologous challenges with Rouen87, W8843, Y5, 6303E and 1705A isolates. Monoclonal antibodies MAbF4.2F8 raised against the protein derived from Rouen 1987/Rouen87 isolate protect against virulent challenges with Rouen87 and Weybridge 8843/W8843 isolates but not 6303E isolate.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Vesicle. Note=Localizes to the membrane of the intraerythrocytic merozoites and inside parasite vesicles.
Sequence:
MKTSKILNTAAICLLAMGFNGNNVSCTNLNGSQEPAAANPVVSTPGNDAQQAGTQQGGANSKSVPEQQPQQAAGETTATVVVKTLDVLRGELRGQREAFLSEIIKSDGPFTILQLVGYLRVVDTDLLLKVDSTKVDEAGKKVKAYLEKIGIRGDSVEAALDNLMIKVYEITKGTVESSAQGTDSEELKTLLLKFSEDLKAEQELHSEAKGGEALLSSMKTQHDELLKKFAALTPTFLTSEDISGYLTVPEYGAPMNAAKWKKVEGMIHGKLESSEVPANLKALVAELIELREQMMDLLYGPIGHHDCAAGSGQGSSPKKPSFAAVPSSLSAIVFGIIVSMF
The following text describes a protein:
Function:
Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MLGIINLQGFTRDLSLYLENQVPVGLFGSGVGLSLVLGFGAAYACYYLSVIAKRPQLVVGGEGLCNFLKHHCPAVTETYYPTLWCWEGRAQTLLRPFITVKPLVHYNNELIKTADGGQISLDWFNNDNNTLYPDASSRPTILLLPGLTGTSRESYILHMIKHSEALGYRCVVFNNRGVSGEDLLTPRTYCAANTEDLEAVIHHVHTMYSEAPLMAAGVSMGGMLLVNYLGKMGRQTPLKGAAVFSAGWEVFESAITLEKPINWMLFNYYLTTCLQASIVRHRHVLEKQFDIDHILRAKSIREFDTRFTSVMFGYPTNDHYYKDACPCHRVKSVEIPMLCLNAMDDVFSPGHAIPVETAKQNPNVALVLTSYGGHIGFLEGIWPRKQTYMDRIFKQFVQAIFEHGNEINSM
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MSQDTGLFSVRRPRETLGSINYNSSLPQPASAMKRSNSIGGYNNAPFTTSHVRSGARQSLAPSRPNQPLFSRSSSGTNLADIGTSSVKRTSVQNSSGRKSYAPPQMGRASAEGAERRSSVYRSRSSTSGPMGHQSFFQTGPQPAGVPKDPRPLRDRAYQGKIGQELLEYMANNNYDIEMNHNVSANTLKSPTQKDFVFMFQWLYHRIDPSYRFQKAIDQEVPPIMAQLRYPYQKSITKSALSAVGGANSWPLFLGLLHWMMQLAQMLDGYATDRYDEACAEAGVDVSGDRIIFNFLSSAYRDWLSMDEDAGDDDQDQVLAPHIQAMAQEFNRGNSKYLDEMRVLEGEHERLQKEIEILEKTGSDIATLDRNFKTMEDDKVKFEEFDNLMHQKSEKYESRIQFLQEELDKVLQELKEASDERSRLQEEIDSRGMSMQDIDRLNSEMERLQKGHEASQQRLEEARRKVAEKELEASRKLEELERVVEKYNSLGYQIGLIPSTAINAKGKNYELKVVVNEGPNFSASQMASSHSGGRDGDRLLADPTTGYQPAHILNLDLRGHVKNSFISLRKEISERRTLAVEEMEKHNDLLDNIKEAIDDKRSEVEALEHRVRAAEEEYEKTKEVTTTQKLASDAQIEKMEKELAKMRAGLTESVQLMEQREMNTNIEYEQLTLRANTLREELHTEIEKMLNDIIKFKVHIQKNLEDYEGFVVDEVEHELGGDDEIRDDTQDIEMSG
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSVFFDIEAAAYVLLLIICTATYLRQYSPTLFHRDHTELHRKFLYKCSVVGDRLSLWVATGCIVVAVRMLFVY
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSRRGTAGPASAAARARARRTAGRQQVEAAWHQAVEEGDSEDEHMNRIRARMEAFDEPSSDENEEQPDMGAELPSDSEQVTYVQRQQQRLQRQSRRPRQAVSEDEDEDEDEDDTGGADETDDADQLESEESDDDDDVEGLQIQFDDDAEVQRYHAAAEDGFQALQALQEEMGLKAFRQLKARAAQVSQTASTGSTGQQPAAKKPRRQRGSSAPQEVSSKRRPRGVRQVVASYKPRARDPRFEAVSGTFHADKFDRNYEFLEEKQQQELDTVRQELRRTKDPERQEQVKRLLQSLRNKQADRKAKRTARERDHARRQAMHQAGLIDQETGLAKYHLKKSTQRQLDLLAQYDQLKSNSQLNKAMKTRRKHRVAKLKKSFPNKREEY
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Sequence:
MFSDEKYLEICSEKTLQVDKEGFFLQFAKTVAENVGEKWVKNIFGKLKTDSQRIRIIYKDDEIKDYIIGFLSNVQEIYRKKSPEIALNRFSEAEKCGDSQKALNLYNQAILKSPESDPTLPLALIRRANLLVTLNEFSHALTDTQLALKLKVPNDLKFSVFATMAQCYKALNDETKAQISQNLAENLTNDPKLIEKLRQTMAGEYAPIERVEKVIPPISERHADFSHASSKITLKTSPDVGRYVVSNVDIATGEILVAEPAAVACLNPEKFGTHCQHCFARLLAPVGCPHCSSVAFCSPKCRDDAITTYHKYECKFFDLLLGSGMSVLSLMALRIITQQSLTQTLEIYDKKNTNALYNLCTNESKRQNSDFLQRSLMAAFLLRCLQKSGYFGENGTVVPTQTEHKVGEMLLHYLQILQFNAHEIYETLYSEDHSLKSAKMINIGVAVYPTVALFNHECYPSVTRYFVGKTIVIASIRPLTPNTPISENYGPIFTRIKLAERQRTLLGRYWFNCQCQACLEDWPLLTNESNYVKRLKCPMVKCSNLFPLSPEIEKCPKCQTKILLKELIEKLDWCENQFKIGIDFVKSGKREEAIPVLRQALDTFHRVSAPPNGETHRAQEALRMCLADQGNTFDCLV
The following text describes a protein:
Function:
DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins.
Subcellular Localization:
Nucleus.
Sequence:
MVMSELRWHTASPEDNKNSLKRDLLKSTPTSAREAAVHIMQNRYISRLSRSPSPLQSNASDCDDNNSSVGTSSDRCRSPLSPALSLSHQQAKRQLMSLQPHPAHHHHNPHHLNHLNHHQYKQEEDYDDANGGALNLTSDNSRHSTQSPSNSVKSATASPVPVISVPSPVPPMISPVLAPSGCGSTTPNSMAAAAAAAAAVASTMGSGISPLLALPGMSSPQAQLAAAGLGMNNPLLTGSLSPQDFAQFHQLLQQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPSLDSPTGADDDESSYMMH
The following text describes a protein:
Function:
Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by HEL2, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes.
Miscellaneous:
MISCELLANEOUS: Present with 6300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
The CUE domain specifically binds RPS20/uS10 ubiquitinated by HEL2.
Sequence:
MLSRYNRVIEINGGNADISLPIVKFPPFKLRAQLIEKDPVVWLHLIETYVTYFEYLMQGANVELLDESTLDHLRLFLRTYLHEIADEEGKLLSLGINHDVSEQLYLLKGWIFSLIKKCGLLHLQIFGDSLWNLIKVYVRRNPDSIRGLIDGSLKPRINTQRVQLDKSYQVQQHLKQLIESGKFKRIDLRCVEDLLSAKSMQPNKFAENFFTANWIEILEALWAKGQGRGHKEARELIIISLFSVSADRLLKITKELGISNFETLALYPLLGTMLINEGVHKRLPDLKSKLLFLNLGGLSMDEGDHMSYPTSSGTEVNEEQLSALMELFPQFSKYQLSQTLLAYDNNIELVTNKIFEDPTIIEAFSREPAEEEVEPVSDGDNASFTEELSILDRGDSSKNKELDKKIISEGVPDELRNKTLTRALKLLYEADEDERDDTYDEADVNRSDPSKRIGLQEDEESYDTKDDSNEVRQDHNYHIVEAYLWNLLKEDPKLFERSKRGTKVRKTMKEMTSWSDEKIEGWCRMLERSPTRARLLEKKFMFKGNSKTGKTSYVHNRDSQNDGNVVKEQAKQKKSENIKKHEPQSTEQKKRQHAKNEKRKGARANHNRKKGHDKKLARAGNNAI
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSESTTQSTDINPDDTIKILVASDIHLGYNEKDPIRGDDSFIAFEEVLQHALENDVDAILLGGDLFHVANPSTNTLDRCFRLLKTYTLGDKPIRLEFLSDQNDNFLESLSRTVNYEDPNMNIAIPVFSIHGNHDDSGGAGRVSSMNLLSTNGYVNYFGKWTDLSKIDIRPILLRKGETKLALYGLSYMSDARLCRLLDDAKVFIEKPDEHGFFSIMVLHQNRAERGPKNYLPESSLPQFLDLIIWGHEHDCRIEPEENAAKKFYVSQPGSTVATSLSEGEAIPKCCGLLSIHKGLFRMDPIPLKSVRPFVFESIDLATVQEELALDEGDVQQRVQAFATERIEAMIERAKQQQSGYARQPKLPLIRLRLVLTEVEQQFNAIRFGFRYHGRVANPQDMVIFKKKPKAMVKDELGKMLDKAALQEAYRNQREQRAQRAEEIVDRYFREADVMNQLEVLYPRSMTELCRRMVDYEDDEACEKIIKFYENKALEFLRAQDNLSEEGICEALAGFPAADPEVHEKVLHMLDTRSKPQDAVDPLRRFRDLDDEAENNDGTTGKGTMDTTAAKPARGARGGGARGGRGSRGGARGASKATVAAVTTTTGAGASRSRSQTSISSLFASQTSNNGSIASVATRTSSRKPAATKARQMDFDSDDK
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MATSQRKILVTSALPYANGPIHLGHMLEYIQTDIWSRYQKLRGHECHYICADDAHGTPIMLKAQQLGMAPEEMIAQVNKEHQQDFADFNIAFDNYHSTHSEENRVLASDIYLKLRANGYIKSKSISQLFDPEQSMFLPDRFVKGTCPKCKSPDQYGDNCDACGATYSPTELINPKSAVSGATPVMKDTEHFFFDLPAFEDMLKEWTRSGALQTEMANKLDEWFEQGLQQWDITRDAPYFGFEIPDAPGKYFYVWLDAPIGYMGSFKNLCDKRPELSFDEFWAKDSKAEVYHFIGKDIVYFHSLFWPAMLYGSGYRQPNSVYAHGYVTVNGAKMSKSKGTFIKARTYLDHLDPEYLRYYYAAKLSSRIDDLDLNLEDFAQRVNSDLVGKLVNLASRTAGFITKRFDGKLAKITDTTLTEVFLAKQEQIAEFYETREYGKAMREIMALADIANGFVADAAPWQMVKHDDQQEAAHQVCSNALNLFRILVTYLKPVLPRLAQDVEAFFQQTLTWDGLGQDMAGHEIAPFKAMMQRVELDKVNAMVADSKENLQATTEPEAPKGPLATDPISDTINYEDFAKIDLRIARIVKAEHVAEADKLLKLQLDIGGETRQVFAGIKSAYSPEDLEGKLTVMVANLAPRKMRFGMSEGMVLAAGPGGSDLWILEPHEGAQPGMRVK
The following text describes a protein:
Function:
Required for meiotic double-strand break (DSB) formation, the initial event for meiotic recombination.
Sequence:
MRHNIKFKSKGTLKIRNTAQISLWKKCSDSMIADQTYLFINRVQDRRFDEESLRILELSLVAMNVKSFLEVRSRLRDFMRSESVVIFGELTGESMVAKLSVLEFFARAFALLGDMESCLAMRYEALNLRQLKSPSCLWLGVSHSEWTKFAVQSMENGFPSIAGKASENALLSLKKDSLIEPKSEDNSDILDAAEKVRRLRDSAASLTSSHSGIFIYIVSSLKFAVCNRLLTTF
The following text describes a protein:
Function:
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MEMLPLVKIAPEYNLTLDPSTGMIGAALGREVIILSMDEINEQIAALEATADDLINSLDPTTIPEGSYPGREGVYLTAGKLTNIVYGFILGLIILFALLL
The following text describes a protein:
Function:
Ribonucleocapsid-associated protein that interacts with the phosphoprotein (P), thereby increasing replication accuracy and processivity of the polymerase complex.
Subcellular Localization:
Host nucleus. Host cytoplasmic vesicle. Note=Relocalizes from the nucleus to the inclusion bodies in the presence of P.
Sequence:
MSKTDWNASGLSRPSPSAHWPSRKPWQHGQKYQTTQDRTEPPARKRRQAVRVSANHASQQLDQLKAVHLASAVRDLEKAMTTLKLWESPQEISRHQALGYSVIMFMITAVKRLRESKMLTLSWFNQALMVIAPSQEETMNLKTAMWILANLIPRDMLSLTGDLLPSLWGSGLLMLKLQKEGRSTSS
The following text describes a protein:
Function:
Transcription regulator involved in iron deficiency response and tolerance. May regulate directly iron transporters or other transcription factors involved in iron-deficiency response. Binds specifically to the DNA sequence 5'-CATGC-3' of the IDE1 element found in the promoter of the barley iron deficiency-inducible gene IDS2.
Subcellular Localization:
Nucleus.
Sequence:
MGQMDGGDGGGGGHPYHYQALLAAVHQQTVPFPNPFPAPSSGAEPPHPHNHNHNHNHNHNIHNSHNHNHNHNAAPHPCHTPTPTPTPRGFADWSASTSAFTSLAAHSSTAPSNAVHYSFSPCYAFWTHYMLNKNAYPTSFPAPHDDHLRLANNNHPRDAPGPASSYGVESFTSPSMAPNICTHMPPIEGPISAKEDKKPEILPRVVKSSDELETRNSNVEFHSETVGTLPESKQGHDSRATKLLNSGEYQVILRKELTKSDVGNVGRIVLPKKDAEASLPPLLQRDPLILHMDDMVLPVTWKFKYRYWPNNKSRMYILDSAGEFLKTHGLQAGDVIIIYKNLAPGKFIIRGEKAIHQQTTNP
The following text describes a protein:
Function:
Binds preferentially DNA with A/T-rich content.
Subcellular Localization:
Nucleus.
Sequence:
MSTDSSQFEVVPANASALDNDVSSHMSMLYQDIVRNPELFWEMLRDFHESSDKKFKIPIVGGKSLDLHRLFNEVTSRGGLEKVIKDRRCKEVIDAFNFKTTITNSAFVLRKSYLKMLFEFEHLYYFQAPLSTFWEKEKALKLLIEKSANRDKDSQELKPGTVITGIIDGKFESGYLISTKVGSEKLKGMLYHISPETKRGKKKAKSSQGDSHKPPKRQRTGYNFFVAEQSVRIKAENAGQKVSSPKNFGNMWTNLSESDRKVYYEKSREDGKRYKMEILQYRSLMESRVAEIVAATDAGTSASAAETADEASQENLAKTDACTSASSAAETEDEVSQ
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression.
Subcellular Localization:
Nucleus.
Sequence:
MFRFPVSLGGGPRENLKPSDEQHQRAVVNEVDFFRSAEKRDRVSREEQNIIADETHRVHVKRENSRVDDHDDRSTDHINIGLNLLTANTGSDESMVDDGLSVDMEEKRTKCENAQLREELKKASEDNQRLKQMLSQTTNNFNSLQMQLVAVMRQQEDHHHLATTENNDNVKNRHEVPEMVPRQFIDLGPHSDEVSSEERTTVRSGSPPSLLEKSSSRQNGKRVLVREESPETESNGWRNPNKVPKHHASSSICGGNGSENASSKVIEQAAAEATMRKARVSVRARSEAPMLSDGCQWRKYGQKMAKGNPCPRAYYRCTMAVGCPVRKQVQRCAEDRTILITTYEGNHNHPLPPAAMNMASTTTAAASMLLSGSTMSNQDGLMNPTNLLARTILPCSSSMATISASAPFPTITLDLTESPNGNNPTNNPLMQFSQRSGLVELNQSVLPHMMGQALYYNQQSKFSGLHMPSQPLNAGESVSAATAAIASNPNFAAALAAAITSIINGSNNQQNGNNNNSNVTTSNVDNRQ
The following text describes a protein:
Function:
G-protein coupled receptor; [Isoform a]: G-protein coupled receptor for flp-13 RFamide neuropeptides in vitro. Upon activation by flp-13 RFamide neuropeptides, promotes sleep in response to cellular stress also known as stress-induced sleep (SIS), probably by inhibiting the activity of wake-promoting neurons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEFTECKTTFIHLPDKSFLYDVFVSVYNFYHPIHAYLSIFLCVLGTIANFCNIVVLTRRTMRTPVNMILTAMASCDTVVLFSNLIYTTHYSFVAFKFCHPKHWSYSWALFLIAHAHLSLVAHSSSVWLSVMLALVRYVTLRSRGNMGGMQVTLRHSYYAVAVTVSLVAVLNAPNFLNYKINEQPLNETCTDLDPMFWNSPAYLPGIADIAKANSCLVFRLSYWISGMVFKVLPCALLSLFVWLLLRILREVRENRQRLLKNSQHRPPNQTTTRNGQRLSISVAGNEKLGRNGSLRGRGERVDRTTHMLLAIVAVMLVTELPQGIMAVLSGMCSEEFRIYIYNNLGDILDLFSLCGSCCSFIIYCSMSGQFRNEFHRVFVPAKVRCLRMSSPSIRRPSDAYSTTKMTFLKPNEKNGNGMNGNGTYSEDTRSASVKMVGIQVRRNSTEITRMTGCDSITPCSPMPTSFPSSPLPPIRSGEDESTDETSHLLNSSGPNSTASADGIRGHFQNI