lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Collagen binding transmembrane protein involved in collagen secretion, probably by recruiting the ER-to-Golgi transport complex TRAPPIII.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
Possesses a PapD-like (PapD-L) domain similar to PapD domains involved in assembly and secretion of bacterial pilus components. The PapD-L domain can bind collagens and is probably involved in collagen assembly and secretion.
Sequence:
MPTQVQMRPLLRIFAEPILLILIFLFTLGAKGEKVLQETFLGLQEAPIHDLGDLRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFNVVFLPRQLGAIAADLLIHTSFGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEIHMYNPHERPLQILEIYSSGGEFQLELPSGGSEGPQNLWKIPPHTLKPVIRISFHGRTAGNHSAYIRIKVAEQELDIFIPVEFEILPRHSVYARNPLADFGRVATLNAPDALQFKLDVRNDESRQLFGSYLRQIPGLSFDANNTSIVLDASLFEGDEIINDLLVINSNQSSTSPGADQPFTVLVRAEIFHGGLTFDRNATRFVTTSPEGVEGEPLERKRSLVVRNKFAIPLMLFNVSLTEPIDESILEVTLVGDPRILIQPDESVELLRLNLLNDQVPFKSFLRIETNVTVFKLPLVSCSGRLHVSTQPIVLNFRQESLEKAAYNLELDLGTVPFAEMSRDGFVILRNDNPVPVRITNWFFKHPKTVYSQSTFLGCRATAIGHPVSVENDTKGWHLCTEIRAGESAVFKVAIQTYEADATFGTLKVWTPYEVIRVRVKFEASVGHLEIDQEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGISFALPVGLRFKDFNAKGTTIAPQTLTKVGRIYFDPASVCRNNCYIRESTNDLAIFPSVPGGGNGNSGVINNNLLYDGVELRQRTELFRQLRRQLSSMSLTLHSEELPPLELDFSITIEWPKLVQFQPIPPTPAIEVGQVQRQWITLTNPSQSPLLLDYFLSDPAFARRTQLSLPHEVIDVSSTSCYLTDKEVFSLPEAGDPILLPGGASLTIPITFSAQLPEKYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGCQSGNEAVVVTRSFTARNSGVIPIRIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCASLLVRPGWESSLKNAALVVLLASFGLVLVAAVFDAKAIMVQQNAYDAARNKGPLQPTFNLRNIVKLQAEEAAAKAESVQQQQKVKNGQLKELRKRTVVNSTNSKSKSKSSWSPWSMDMNALSKHLQKAKPKTVVSTPVTPPAASAPAAAPVPLPEAKPVKKSSTPSPQGVPISVQVRPQKKVKPTPAVVLGTTKPKQEVSTPVADQHEKSLAKSSPPQQENISPKPNKPPEQRVLKEQNGSAKKMGKTPGRERERERRSKDQKLTNGTGAGVGFRKPERKQRQKLNFGQTTNSTSPPESPDALKCISNPWETSSRVSFRDVLRTPQMAPTDNGFDWNHATSSSDLGPIGDNRKNATPPMVTSLWEPLSATASNSLFANTEVDFITPDAIYEQREREKPQWEQRSDLVMRQQLLLQQPQKLEFQLRQQEKISLLANMDPSNWATNWSPLGYSTWPNATAGIGVMRPPPGLEQSARQTHNLAQEQVSAGPASGTGAALHGESLPTQYDPFTSPSSIWSDTWRQSSQRNNHNHMN
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MADVAIDVGNCCKRLKKLYENWTTQQDGVWAGANVLAVAVGAPSEDLRYLKSNSLHMWLFGYELPETVMLFTNNRVHVLTSQKKASLLQPVVEACEKGEAGDVRVEVLVKPKAEDGAGQCTQLLDAARTASGSPVVGHLPKDKHTGKLIDVWTSAMTESGLTQVDINNGVADLLACKDANEILNVKKAALLAAKAVQNWVVPKVEDVVDSGKKMKHSKLSEMCEEVITDPTKVQVKLKAENCDIAYPPSFQSGGVYDLRVSAPSNDSPLHDDGVIVVSLGTRYASYCANISRSYIINPSKDQTAQYNALLAAQEAAITALKPGAPLTAAGEAVVNSLKAGGQEALIPLLSRNVGFGMGLEFREGTHVLPLPGSGKAAAAGEDGAPRVRAGMVFNVCLGVAGLTNADASDPKAKNYALQVADTIVVVDGDRPNEVATQSAPKNFDKVTYTIQEDEEGAAGDGRLEDVTNGAAAARGAAAHAAMGIKKTLRSDDPTFKSAEQLRKERQEELLKKKNEETLARLTAQAGGAGGAGGAGGAAVRKISETHAYRSVTEMPMARDLRIQVDTKNEAVLLPIYGVLVPFHITTIRNVTTTNDAGGDAALVRVTFNLGNSYEPNQRFPNCIFLKELSFRSSDVKHANKVALDIKLLRSSIAQRDKERAERATLVAQEKLIRGKKIFKLPDLWMRPAFPGKGRKVPGSLEAHANGFRYQTPKGEILDVMYRNIKHALFQPAENEMITILHMHLHNPIMVGNKKTKDVQFYTEVMDVVQTLDGGGRRNMYDPDELEDEQRERERRNKINGEFQQFVKRVQEMWGKDCPDLNLEWDIPFRELGFSGVPHRSTVFLMPSVNCLVELTEMPFTVTTLADVEIVNLERVGFNLKNFDMAIVFKDFTRDVLRVDAIPAKSLEGIKGWLTDMGIKYYESKLNLQWKPILKNILADPVGFVEQGGWDFLDIEKSDDEEEEGEASEEYAPSGEDDDDDDDDSDSDDDSDASLEEEEDDDEEFDEDESEGKDWDELEEEARNADKNRHYSDESDGERRGKKRKAGAGGASGAGGGGGGERGGGGGGGGGGGGGGGSGAAAKRRR
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MEEQKNLLTDGINGFRPDCNVPLPATSSGFWLSSSPLQASIPLVMIQMTIIFLICKSLHFVLMRFGQPTIVSQILTGIILGPLFLGKFELIGNDIYRPNSLIPLKTLGFIGLGFFLFIIGVKTDLNMVWKSGKRAVGIGFVGNLVSLLPVVCAHFLLTNLLPEDLSVNHTSSKDVLYFWCMSSFVVIASVVDDLKLLNSKVGRLAISISLIYDLFNIVLARILTSIQIGSARGVGSIASFFGLLAFVLLVARPITLRLLKLTPKGELLDEVYFATVVMLSLTCGFLSEVAGHGLEVGMFVLGLALPSGPPLGITLVEKLEGITLTLGIPIFVASVGISIEPFVVGNNSWCYLVFMLLLSFCGKVAGTVASAIFFDFPIYDAVALALILASKGIIELRLISYWQFGHTMKPEYVTTILIYVAFLVAVTTPVIRFLYNPSKHYTSDQSNMRNIEQTKSNYELRIIACIHSEENVTPIVHLLETLNADPCPICVYVLHLVQLVGQAMSSLIPYNRKERNYGSSADSSSDAIMNVFRNLEDRSENCITIQPFVSTSPSETMHDEVGNLALEKMVSFIIIPFHKTVCSESSTLASLPNHAARTMNANVLSYAPCSVGILANSTQGSPLPRDVVVYFFGGSDDREALSLAMRMSQNPRISLTVIRFVPPYDSSAESPRTPTQYDESAMLDEDIIEEFRMNYVMDNRVVYTEEIVADVEETIKAIQSITPNFTLLIIGRRIGADSVLAKCMSMWSEYPELGDIGDLVASTNYGTQLSILVIQQQATIVNATPTMSSVQYRTDRCSSSATQKTHQTN
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MHVLLGQNTLHTTLLLKGQLLKQDLTTQCRPGLWAAGLGHGRPLAAALCHAPPRPPCTHRRAHTRLRTQGPFTTPPRSSAEPTAAQFRLRPFRAGAHGPRLFSVCPEQRSRDCIMEARFTRGKSALLERALVRPRTEVSLSAFALLFSELVQHCQSRVFSVAELQARLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR
The following text describes a protein:
Function:
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLNFFLITIQFLSGAVMYSHIIAKIKGIDLRKIRDGNPGSSNLWRAAGWKYGFPALMLDYFKGTFPIAFFVWNESFHVNRYVIAFAALSGILGHAFSPFLKFKGGKAIATTFGAWSVLTKWEGPMVLGTVFTIFSILHRLRGKNKTTPEEDAFRVMIGFAALLIYTMWKVFNGMPELAILYFGNFLIVFYKHRLELRRYLKGV
The following text describes a protein:
Function:
Transcriptional regulator involved in both the repression (at least 99 genes, such as mexR and algU) and in the activation (at least 203 genes, such as mvfR, rsaL, vqsR and rpoS) of regulatory or putative regulatory proteins which are implicated in quorum sensing, virulence and multidrug resistance.
Miscellaneous:
MISCELLANEOUS: Mutation in vqsM resulted in loss of proteolytic and elastase activity, significantly decreased expression of lasI and rhlI, which are responsible for acyl homoserine lactone (acyl-HSL) biosynthesis, much reduced swimming and swarming capacity as well as decreased capacity of killing C.elegans.
Sequence:
MVTEHIFDFEWRPLQNYLRDRDIAIPPFAAEQESRSDALYNWIVSKGYSGKEGLNLGTYYHISDYGVIGLALLCAENVGDILKVIRAYVKLFNRDIANVGVKPRENYEVEIHISVNFKPEWNDASRQFHVNVIASATYKLIMDLLGNDFPISALTVPVHGADKTIYEGFFSLPVKHEGNDIIFSFPAHQLNRTLATANPAVFQSALTMAGESFNALLEVEMGGLRQRIELFLDSIPDQYPSLVTTAKYLRMNERTVRRRLADEGCTYRQIVDKARKERAIALLLNSSIPVDRISDILGYSETASFRHAFRRWTGQSTTEFRNSFH
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASTALAPSWSSSSWLHSFGGNLNAGTKLQDRRTALVVLAQKKAIKTRKIILKEDVTDLGKKGQLLDVKAGYYRNYLLPMGKAQIVTSSLIKEMRMEEERIEAEKKRVKDEAQQLALIFETVGAFKVKRKGGKGKQIFGSVTAQDLVDIIKAQLRRDVDKRIVSLPEIRETGEYIAELRLHPEVTARVRLNVFAN
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MPIDLVTYDQNTSVEVQFSQALERYQLDKSNTSLTSPPSPFDFLQKFKNIAATQALQLGQELQNKNDSDSILREQFENWSLETKLWILVEELYSFRLSNPEENNVEIHEYSSLSLKQEKYLSTHPKLKELLIIINWIQQTTNNSNLNLANDYDANIEQTKWHNTKIAIETKEVNSLLNINKGIDKIVDKLDIDAPLRTNQIIDPKDQLIDSENYAIIYKLLLGGKIQEAIDYANNTGNFALALILVGGAQDYIDPVLDGIKDANISVASGIKHKLLWKETVYKLSQQKGLNDYERLIYNYLSGGDITENLKASKNSWEESLLLYAYQLLSYKLQSFILENNNSEESLSLAISIPKPQSDSIEEILNILSNANSEVSLESRNPLRIISGAIMIDKFESLIENLNQDLVNHNENILRILVHLSIFIAIIKPWGDDQSANLTAIITLYISMLSETNKSELIPVYLSFIPDEKDARETYSMILSSITDKEQQTRQLQAAKKLTQPFVNINEGKDNGDVNVNVNDNVNDNVNVDVDADADMVIVEDDDNNKLINVLRRTVERVMIETAPNYERQQNDPVIVKDDESSVDEIDFKLYRAVEWFYENQMYGDAINATIVVIRRFLINGKLASLKKFAKENNFKQLISDYDIETIGLKPEDDKDRKDGDRDRDGDGDEKITEDTKQELIEYTNFIEALKLIDDWKLFIIQGHPFKGSSVNSSLEKTEKVLKNILQNWLLELNNDNESPSPSSFSSSSTTIVQEFRILYIPYLIIELLTIYENARAQNWKYIKQAYQLINEVADDQSNDYLDCFIKSGRIKEFMAKCGELSIISCEQGITGIFSGTTKTTESI
The following text describes a protein:
Function:
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded. The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA. This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle.
Miscellaneous:
MISCELLANEOUS: A single active site specifically recognizes both ATP and CTP and is responsible for their addition. In contrast to the eubacterial homologs, the specificity of the nucleotide-binding pocket is determined by both the enzyme and the tRNA.
Sequence:
MKVEEILEKALELVIPDEEEVRKGREAEEELRRRLDELGVEYVFVGSYARNTWLKGSLEIDVFLLFPEEFSKEELRERGLEIGKAVLDSYEIRYAEHPYVHGVVKGVEVDVVPCYKLKEPKNIKSAVDRTPFHHKWLEGRIKGKENEVRLLKGFLKANGIYGAEYKVRGFSGYLCELLIVFYGSFLETVKNARRWTRRTVIDVAKGEVRKGEEFFVVDPVDEKRNVAANLSLDNLARFVHLCREFMEAPSLGFFKPKHPLEIEPERLRKIVEERGTAVFAVKFRKPDIVDDNLYPQLERASRKIFEFLERENFMPLRSAFKASEEFCYLLFECQIKEISRVFRRMGPQFEDERNVKKFLSRNRAFRPFIENGRWWAFEMRKFTTPEEGVRSYASTHWHTLGKNVGESIREYFEIISGEKLFKEPVTAELCEMMGVKD
The following text describes a protein:
Function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.
Miscellaneous:
MISCELLANEOUS: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug; MISCELLANEOUS: [Isoform 2]: May be due to an intron retention; MISCELLANEOUS: [Isoform 7]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
Sequence:
MVCGCSALLPLPNPRPTMPATPNFLANPSSSSRWIPLQPMPVAWAFVQKTSALLWLLLLGTSLSPAWGQAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDEKGNFVELGAEFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTPDENGVITFDCRNRGWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVMEYLHVLSRPMVINHDHDIIWTEAYMDSKLLSSQAQSLTLLTTVAMPVFSKKNETRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPKPNYNSVDLSEVEWEDQAESLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLSQLEAMIRFLTRKDPDLECDEELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFLGTRAGLLRSSLFVGSEKVSDRKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRWAEGPESAGEPMVVTASTAVAVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSDLDCFVIDNNGFILISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISAFLTATRWLLQELVLFLLEWSVWGSWYDRGAEAKSVFHHSHKHKKQDPLQPCDTEYPVFVYQPAIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSIFPPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFHPEENAQDCGGASDTSASPPLLLLPVCAWGLLPQLLR
The following text describes a protein:
Function:
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity).
Domain:
Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport (By similarity).
Sequence:
MGIWTSGTDIFLSLWEIYVSPRSPGWMDFIQHLGVCCLVALISVGLLSVAACWFLPSIIAAAASWIITCVLLCCSKHARCFILLVFLSCGLREGRNALIAAGTGIVILGHVENIFHNFKGLLDGMTCNLRAKSFSIHFPLLKKYIEAIQWIYGLATPLSVFDDLVSWNQTLAVSLFSPSHVLEAQLNDSKGEVLSVLYQMATTTEVLSSLGQKLLAFAGLSLVLLGTGLFMKRFLGPCGWKYENIYITRQFVQFDERERHQQRPCVLPLNKEERRKYVIIPTFWPTPKERKNLGLFFLPILIHLCIWVLFAAVDYLLYRLIFSVSKQFQSLPGFEVHLKLHGEKQGTQDIIHDSSFNISVFEPNCIPKPKFLLSETWVPLSVILLILVMLGLLSSILMQLKILVSASFYPSVERKRIQYLHAKLLKKRSKQPLGEVKRRLSLYLTKIHFWLPVLKMIRKKQMDMASADKS
The following text describes a protein:
Function:
Probable regulatory protein for the tcp operon.
Subcellular Localization:
Cytoplasm.
Sequence:
MIGKKSFQTNVYRMSKFDTYIFNNLYINDYKMFWIDSGIAKLIDKNCLVSYEINSSSIILLKKNSIQRFSLTSLSDENINVSVITISDSFIRSLKSYILGDLMIRNLYSENKDLLLWNCEHNDIAVLSEVVNGFREINYSDEFLKVFFSGFFSKVEKKYNSIFITDDLDAMEKISCLVKSDITRNWRWADICGELRTNRMILKKELESRGVKFRELINSIRISYSISLMKTGEFKIKQIAYQSGFASVSYFSTVFKSTMNVAPSEYLFMLTGVAEK
The following text describes a protein:
Function:
Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Promotes the Hippo-YAP signaling pathway and thereby modulates glycolysis and oxidative stress production by the regulation of hexokinase-2/HK2.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGFNLTLAKLPNNELHGQESHNSGNRSDGPGKNTTLHNEFDTIVLPVLYLIIFVASILLNGLAVWIFFHIRNKTSFIFYLKNIVVADLIMTLTFPFRIVHDAGFGPWYFKFILCRYTSVLFYANMYTSIVFLGLISIDRYLKVVKPFGDSRMYSITFTKVLSVCVWVIMAVLSLPNIILTNGQPTEDNIHDCSKLKSPLGVKWHTAVTYVNSCLFVAVLVILIGCYIAISRYIHKSSRQFISQSSRKRKHNQSIRVVVAVFFTCFLPYHLCRIPFTFSHLDRLLDESAQKILYYCKEITLFLSACNVCLDPIIYFFMCRSFSRRLFKKSNIRTRSESIRSLQSVRRSEVRIYYDYTDV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which triggers the ubiquitination and subsequent degradation of SGS3 in response to heat. Involved in the mechanisms necessary for quick response to heat and subsequent heritable transgenerational memory of heat acclimation (global warming) such as early flowering and attenuated immunity; this process includes epigenetic regulation as well as post-transcriptional gene silencing (PTGS). In response to heat, HSFA2 is activated and promotes the expression of REF6 which in turn derepresses HSFA2, thus establishing an inheritable feedback loop able to trigger SGIP1 and subsequent SGIP1-mediated SGS3 degradation; this prevents the biosynthesis of trans-acting siRNA (tasiRNA) and leads to the release of HTT5, which drives early flowering but attenuates immunity.
Subcellular Localization:
Cytoplasmic granule. Note=Co-localizes with SGS3 in cytoplasmic granules.
Sequence:
MEKSQKQVTRPSNSRREYSKEIPIDLLIEIFSRLSTGDIARCRCVSKIWSSVPRLRDFTELFLKISSARPRILFTFLHNGMVPSYDNEIHAPVRGFLCSKASVYNPSTGECAYPYLELLGLWDILPVDAENLAKKVCVPKVLLASEDFACRVSTLGTEEVCWRMIQCSLPHRPFRDEICIDGVLYYLANCKGKLGILWPVPSGDQSHEVTRSFVLRILEDANKLIWSRTVYTLSFNWKKLVNKSLYIVGMTSGGEIVLSTRHLNYPFYIVYYNPVNNTAAKNEIQFGNIANKKAENSRIYTFIDHVENVEHMD
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex.
Sequence:
MTTVTSSSAGLSLSAERPKNIETQHEDMVHDAQLDFYGKRLATCSSDRTVKVFDIVNGTPSTTAETLHGHQGPVWQVAWAHPTFGDILASCSYDGKVVIWKDNGAGASIGASAPYGSQSAYGAPTSSAGGWTKIKEHTLHTASVNSISWAPHELGSILACASSDGNVSVLTFNNDGTWAVDLVAAHPVGCNAVSWAPAVVPGSLISAQSVGANAGAASNGEAKLVKRFASAGCDNTVKIWEFSQEANRFVEVEALQGHSDWVRDVAFAPNVGLPRSYLATASQDRTVLIWTQDSPTAAWSKTALNPISASAAAGAGSNKFPDTVWRVSWSVSGNVLAVSCGDGKITLWKENLKGAWECVSEMDS
The following text describes a protein:
Function:
Promotes K(+) uptake, by the potassium transporter TRK1-TRK2, which leads to the subsequent cellular resistance to toxic cations such as Na(+), Li(+) and Ca(2+).
Miscellaneous:
MISCELLANEOUS: Present with 1030 molecules/cell in log phase SD medium.
Sequence:
MTGMNDNNAAIPQQTPRKHALSSKVMQLFRSGSRSSRQGKASSNIQPPSNINTNVPSASKSAKFGLHTPTTATPRVVSNPSNTAGVSKPGMYMPEYYQSASPSHSSSSASLNNHIDINTSKSSSAASLTSSVSALSLSPTSAINISSKSLSPKFSHHSNSNTAITPAPTPTASNINNVNKITNTSAPICGRFLVHKDGTHEHHLKNAKRQEKLSTMIKNMVGASKLRGEAKSAVPDIIMDPKTTLKSNKNPPTLFAGFMKQVVDMDDKYPEGAPTSGALNCPERDIYRSDQKDSKNNTHNITTTKKDRQCFAEKYGRCQEVLGKGAFGVVRICQKKNVSSQDGNKSEKLYAVKEFKRRTSESAEKYSKRLTSEFCISSSLHHTNIVTTLDLFQDAKGEYCEVMEYCAGGDLFTLVVAAGKLEYMEADCFFKQLIRGVVYMHEMGVCHRDLKPENLLLTHDGVLKITDFGNSECFKMAWEKNIHLSGGVCGSSPYIAPEEYIKEEFDPRPVDIWACGVIYMAMRTGRQLWSSAEKDDPFYMNYLKGRKEKGGYEPIESLKRARCRNVIYSMLDPVPYRRINGKQILNSEWGREIKCCHNGRALK
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MFKVIRRSVGPASLSLLTFKVYASPKRDSPHKTSVKVNELSLYSVPEGQSKYVEEPRTQLEESISHLRHYCEPYTSWCQEMYLQTKPKMQSLVQWGGSKIKKLVYPPGFMGLAASLYYPQQAIVFVQVSGEKLYDWGLRGYIVVEDLWKENFQKPGNVKNSPGNK
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Subcellular Localization:
Mitochondrion.
Sequence:
MQSCARAWGLRLGRGVGDGRRLAGGSGLCWAPRGRDSSSGGGDSAAAGASPLLERLLPRHDDFARRHIGPGDKDQREMLQILGLASIDELIEKTVPTNIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLGMANASLLDEGTAAAEALQLCYRHNKRRKFFVDSRCHPQTIAVFQTRAKYTGVLTELKLPYEMDFSGKDVSGVLFQYPDTEGKVEDFTGLVERAHQSGSLACCVCHRENLGVDISLGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGATRDATGKEVYCLALQTREQHIQRDKATSNICTAQALLANMAAMFAIYHCSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCGCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFVCESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSYTMKLNSSSELAPITWKEFANIHPFVPLDQKDLCELTGYDQVCFQPNSGAQEEYAGLATIRAYLNQKGEGHRTVCLILKSTHGTNPTSAHMAGMKIQPVEVDKCGNINAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVYLDRANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHRGGGPGMGKKYLAPFLSNYPIISLKWNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYMAKRLEKHYRILFRGARGYVGHEFILDTRAFKKSANIEAVDVAKRLQDYGFHAPIMPWPVAGTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNLLKMSPHSLTCVISSHWDREVAAFPLPFVKPENKFWPMIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS
The following text describes a protein:
Function:
Acts in signal transduction. Activates RHO1.
Sequence:
MFNMNLLSTPSSEEGSPQNRSSSMSSVEGKKDRDTFTNLQNEFDGKVFGVSLEESLKVAQEEVIIQKSTNEIGSIPVVIAKSGKYLKENALDTTGIFRIAGSNKRVRELQAVFSKPPDYGRKFEGWCDFNVHDIATLLKRYLNSLSEPLVPLALYDIFRNPILENPKINEHKEQIIKDYEDIYMLLPQQNRHLILYLAALLNLFARNEKKNLMSASNLAAIVQPSLLSHPKDEMCPKEYEASRTVIEFLILHASDIIPNTEKANKDTMPHAGTVAKFNNITVPEMAIDSDEEDFVHPSIDDHMLPRSRALSDSNNFTIHHHHHHHHALFPSPIDFDNNGLSVPRSFKGRTLSAESLSPRLSKLLGNVGNSSNTGIKDPTERVPRGEHKTKHKQRQSWLRRLTSPSRTQP
The following text describes a protein:
Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Sequence:
MKIIKESSAFLSNFEVLKLLKELQSDKPKSGKHAKHVQNLATVSYETVTYLEQTACARQSEENVQKFLEEIRALPFTLTKVEKLQLINHRPTTFVEIQLLIEENEERLSEDDMQTILDIVERTLPPAQDEPENAEGAEDAEMECE
The following text describes a protein:
Function:
Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect.
Miscellaneous:
MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
Sequence:
MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEEAAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALGENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQPSEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPSAVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGNDRDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMVGWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS
The following text describes a protein:
Function:
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MNNAMLLHRLASLRQVTQAASIHTHVKTIAQLSSKYEKDEAKENWLKEQGDGGSVKYTRNGSNPDLGQVTFHHKEKLNAFTGAMMHDFSLAVREAVKDERTRCVVVRGENGNFCSGGELNFVEKIASEEGSYVMNTVMMSSLKKLANSDKVSIAVLEGSTMGGASEIASACDIRVGFVQGKMGVCPGWGGGRFLVKTLGTARAMEYLSTAAVVGAEELHKVSKHAFVAAKRMVVNYSGKNRNPKEREEEERRIFMSVWGHADHKKSIHDIRENLIRAKKEKSHKK