lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSQSDADIKPQDVELPLSSPESPKLTRSRASRPPSIGDASQLFGGGNGLDDFFGPPSTFSNDLAQQASLFDPVPEEPANTSSSFDHDPFAWPSNDQPAQHPSPIPNNSSQISDPNISASYDPSSVFPSDYSNPYQPAPEPHNYNQDHQTANQNIYSSPSLNFDPQGFNDPSRFASPASSYPQSVHHSSTGLGISTSSPPAPYGHRQPALDAYNPYAPAETNPPQNPYPSYVPQQTPAFNPPNPHLADVIPRSVSVNALSHSDAAHQASAYPNLQRPKLVQSATQYASSPLNRPKVYDAYDPPAIRKKKPYAFNTTASLPATPALGGDGFPTQMPMSGLGSFPQNFPTSFTPPPPPPPPPKQRSTSTPAHTHDPIRMSSTGSNDFYAQPPQILNSQRHNPTSFDSDPYNSTTSTDYSPPSHEVLSTSNIDGQYHDFSHQADQYQYGQSPQLPAQSPSTLYMPTSQVEDPYAPTHSSQPNSIPLVSPSASANPSQGSPSNRYAIGQGPTSHFDAQATPPLPPASHEPTYANVLSGMQNSKQKVGSPLKMSIMANAGEEVDDQHQNTFSSYQNVDYSSQFQPQDPVDALSSATRKLSINSEVMGTAALNPEANQFNDGPVPQTPPISFVGTANTKLEGSFNTPEKSMSVPDVQIQPATPQIPLPATSDAGQTVQFDDVLADLTSTTQNRPNDDSKTMETIPLDNFDYGAPNDSNTQYTDFQYGTEYNYEPTQNNMQGIHGLDHSQTSNSNRPSDSPTLYNPYGALPDSDNTASASTLHGYPSSQPAELTNVDPHAPYNNQPSDYNLMGETPAYGSTNDHSQSLYGFQPEGFTHDQSMTSRENVSNDWPLESSSAEQVKGPSAYNPYDPIGQSHPDLMSRQMEDPMSERLKARVPVASFGFGGKLITVFPTSQGGTINAGQAPGYEDPYGSGGMFPTGADSGTTVTLQQLSEVIPSSDLQSFPGPLFMDGGNKSNLGKKRKEVVGWLEAKLDESEKELVFIQSTLVGRSLNQDESNDAKVENLQDKIMLLKLLKLLVENEGKLSGTSKVDEAVRLVLQSMDSQPVAVEATSVLSSLSPSDSNPQDIITTYHTRSSHLDSIQALLSNGDRQKAIQVAVEQRMWPHALIIANSLGSDVWRETVKEFVRFEMGDGDLSSLGPGHLGSAPSSPASKGREGLRTLYTLFAGAGPAAVDEFSPSGSHRSSSHFESHAMSTVPTGMGASQLGTSRAPSPAPLLHPVRSSNAKIPNNVLHQWRSVVAMTISNRVPGSTPFLLRLGDTLLTNGRTYAAHITYLLSNGLMPQLSLENGNRISLLGSPTISNPDRPGLDLEAVMLTEVLEFALSLSPVPKNVEQFIGIPHLQAYRLALGLEYATFGLVDRANKYCEALAATLKLATKPCPFYHAPLFDQIKALSGRLSATPLADKGSSWIARKMPRPTLDNVWQTLEGRVHKFVAGDDDEGSNQAASTSIGSASQNNKVLGPFSHYSSISPGSVSGSVSRVQSSNDLGQINTQTTGGLAGPFHHNANLQRPSSGAGYSPSYYSKDPRRASPSNQYEGTSLSPVDYAGFRGQTSSVPPLNSYEQIGTATGSPANPSSPGETVTGENAATTSSGGGWWEASNSYGTPANNTSQPVFETIQDTPIADDGSGFIDPMASFGGPTFGSPIPSMMPSHNNFESSQASKTDFIDDEEDLGFGNSSSRKRDRGSNAGIDNDQRTTDSPSNQRNTEKNDGKSAETDSENKTVKNAPSSSWLGRWFKRDSGAQAPPGSGPVKANLGEDFSLVYDPETKRWVNKKAGASQSASPGGSTPPPPRAQTASPTSAMRPAQMPPTRTSTNSPGPSRVFSSGVPPPPAMSRSNTTGINNDRSNSLDISPSSPAPAAHHSSDDHKQNPTTNTPPPPPSSIAGKKANAKKNIRSRYVEIR
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLKSMSIKNKLQKNLLKEYKNDDEKNFVNPHEGDKASILQETRVFSSYPLNTQKCLQILTKILYLINKGDDILTSQECTDIFFSITKLFQSNNERLRRMIYLLIKNLPVSEKEIFIVTSSLTKDMNSANDCYRANAIRVLSKIIDFSLATQIERYLKTAVVDRNPFVSTSALLCGLNLYNNTSSDIVKKWINEVSECINSKHPMIQFHALTLLCSIKNQDKLALEKIINSYTKNSHTLSSSLANCLLIKYASYLIYCTEVHSEMNNNNNILNINNNRNIFNHNIYYNKDTYSQHYPHNNKQNINNTAISSTTNKNHHHNINNNNNNNNNNNTYNNNDHSVNKNKFIHPTTKVCFDYLKNCLKNNKDAIILFECIKCIFELAIYDQEGKNTTTVFNVDILNECIKVCQLFLLSSKIVDKFSIIRQINKLAHHRPYVVSKLNQDIENLLYDNNKSICVLAFTTLLKTGNETSIDKLLNQINNYMTADNTTFKIKIIEEVKNLCFIYPNKCNIILNFLSNNLRDDESYQFKASTIDSIILIITNLPNAEETAILQLCEFIEDCEYHALLLKVIRFLLMHIPKTKNPSKYIRYIYNRLLLENSTIRIDGMYALFYIALKCAENSKDILVLLNCLLADNDDEVRDRTNFFYYMLKEKIKELDTSNKQISNEYEEKLQNNENINEHNNIHYSNNNLIDQLLEYDQNTNIDQLLYFISNHIEKDPKEEFSYQHVKEQIIASNDLNNKDYVSSPFINKKNKTSYNEIPNLTNTNSISNINKYIDLTPDTLYINNMSKYIDMYNLSNINIINKSIPLTESEAEYTVFLKKFIYNQHLVLEFTIHNTLSEQILSNLNVQMHSSENKWTILEKTTIDNLYYNTPQQLYVILKKNIPFEKTDTHNHNNNDTNDQNNHNLQNNVDSFAVNQNFQISLHFLVKENEHDEGFPDSYSINPFSIQIVDFINPKILRHGEFKHIWDSMHNYNAEVVSKFSLNFQNIQQAVVGLLNTLNMVACDQTDYVENNSNNHNMLLSAQFLNDTYVLCKASLILSQQYGCLLKITCRSTNKFLSEHILKSLE
The following text describes a protein:
Function:
Plays an important role in the degradation of dermatan and keratan sulfates.
Sequence:
MYTVSGNMRVPAALLLPLIALPLLSAIQSIQENEIRERQSLNGLWSFVREPRNSVDIGLPNGWKDENLSKFKNATSMPVPSSFNEMGDKDLRDHLGWVWYERYVDIPLRVLANNRVFIRMDSVMYYAIVFVNGQEATRHEGGHLPFEAEITPLLAPDGHNKFTIAVNNTLSLDTVPQAEFVYNKKEWNIIDGRNTSRYPDGAFTYTVPFDFFHYSGVLRPVNLLIRPKTFIDEYKIDTNSKGEFNYTFTVDGEDRKKVRSTVRVKDADGNTVFESKELVSSGQVEGAQLWFPRGMGAPYLYTIEAELRDSTGTRIDVFRETFGFRAVYINGKHLYCMGVGWHEESPIRGRSFDRVMMSKDLSLFDWLGINCFRTSHYPYAEETMREADRRGLAVIVEQVHQEITSRSRIIAQGNDHEGLQSAFRDHLECIERAVRFRLVQGRKGILRVNELSGVKEPDTGLAPPALWDIAADKQAMQQEQRLQVARCTKIIIAEGQDHRRLLLRMIANSMVTTRNTTKITSNLELKKIISILTLSPPLIDLMHKLDASRPVTLVHGQTRYWNDYLSDLLDVICINRYYGWYIDMGVPPEQIESDLYYDISMWREKFKKPIMITEYGAENIPGVLAEPSLAFSTQYQQEVFQGNHRALDRLRKEGKITGEMPWVFADFMTYMSTTRVGGNHKGLFTRDRQPKEVAYMMKIRYDALHAELDG
The following text describes a protein:
Function:
Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis. May be involved in mitochondrial transport or positioning.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Domain:
The MyMOMA (MYO19-specific mitochondrial outer membrane-association) region mediates association with the mitochondrion outer membrane via electrostatic interaction.
Sequence:
MLQQVNGHNPGSDGQAREYLREDLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQARYMADTFYTNAGCTLVALNPFKPVPQLYSPELMREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKFYAVVATSPASWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRVACQASSERNFHIFYQICKGASEDERLQWHLPEGAAFSWLPNPERSLEEDCFEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEWSFINYQDNQPCLDLIEGSPISICSLINEECRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQQSQDPLLMGLFPTNPKEKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHFSQAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRYADICPEPSPYSITGFNQILLERHRLIHVTSSAFTGLG
The following text describes a protein:
Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Miscellaneous:
MISCELLANEOUS: Present with 6770 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Bud. Bud tip. Cytoplasm, cytoskeleton. Note=Found at cortical actin spots at the site of bud emergence and at the tips of growing buds and shmoos.
Sequence:
MSDAQFDAALDLLRRLNPTTLQENLNNLIELQPNLAQDLLSSVDVPLSTQKDSADSNREYLCCDYNRDIDSFRSPWSNTYYPELSPKDLQDSPFPSAPLRKLEILANDSFDVYRDLYYEGGISSVYLWDLNEEDFNGHDFAGVVLFKKNQSDHSNWDSIHVFEVTTSPSSPDSFNYRVTTTIILHLDKTKTDQNSHMMLSGNLTRQTEKDIAIDMSRPLDVIFTSHVANLGSLIEDIESQMRNLLETVYFEKTRDIFHQTKNAAIASSAEEANKDAQAEVIRGLQSL
The following text describes a protein:
Function:
Transcription factor that acts as the central regulator of the MDR1 efflux pump. Other target genes include those encoding oxidoreductases, whose up-regulation in fluconazole-resistant isolates may help to prevent cell damage resulting from the generation of toxic molecules in the presence of fluconazole and thereby contribute to drug resistance.
Subcellular Localization:
Nucleus.
Sequence:
MSIATTPIETPKSPKSTEPQVRKRKKVSTVCTNCRKRKIRCDRQHPCNNCIKSKKHNACVYDDGQVSPANFSTNGSSHGNTVPESRPYEESARIPIRFDAEAPRKKSKPNTPNNERKNSKKSPDNTVANNQQTASENEVTITLSELNMLKQRLQNIEANINAQSNPQSNPSYVPQTPAYPTQPNILPPPVSFNSWSPKQSNERVMFSPQQRLTTNYNVSHTRGQSPSIQLPPLSFKDTPRASIDSAPLYSEMSPPRSDLIASSLTSPESIQMSVSGDVVGVNPYLNETETINFYDGYTSICVRDFRRVNHGPFAWSSLMRKDKALSSLWNHILKKKEKKNVASQTFVFGQDVHEISQENTQLVASESNESETKFKKKTLETFGFNDVVPYDILKKKLQTQINKTTSPLGLTLYEEQVNMELQLVDRIHQQLPKKKVLWKLIDRFFSLLYPFMPFLDEIDFRESVTKIIGETEYKDEKIKELKVEKRLDLAVIGVLLIILRMSYLSLFCNKESVNEMRLKTTDPSPEAQDMKYLLQNPIGISLIDSAQNCLQYFDIFRKTSMPVLQCAYFLQLYHIFAPEDGDDGDGADTYALNSMVVRMAYSMGLNREPDNFKDVLNDKRQNHLGRKIWHFLVIGDVHNSYAFGTPKLIGDDFYDTKVPFIEEGNENLIDKSLDQYVTKSVFPGYFSIYNSVDQILKLILSVSRRSKVSEICKILNQFEIGIAEQYGTLSDCLKPKENLIHIFARNMPVKMYISLKSFLVSVYFHLFLYYEHKNDSLSFFYLRKILKTGAGDIMPHYFELLGNSEVVCDMVINPKLIQIIHKANQINIALIIRVNMSIYRMKNSQHHAENCKKDDFYYSYYKELCKFSSCLTRCAEVGIAAVSKLSTRYYYAWKITKGHNFLLKTITSMEFYEKESTNAQEITLPKYKLEQIADLENICEVALNKLGKTSVMGDEFCSNVNYKKYKGDQTYSTSSESSSTPNKDSPLDSRKYTNDFGLDLVNNQEIDKIWLQMLSLKSEEAQQQRQQESQPFTSSQSQSQSPLTSANQGYMPRPESRRGSYYGNTPFALENLNFDGFGGQSKSSNNGEADLSSFDFFVDLPFDQLFTN
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Sequence:
MKTDEERVAFALRLPSVQENIIIKQTASTKSSSTAASLRNEGNTYFQKRQLGRALEVYTQSILVAPSTDLKVLSLAYANRSAVLFHMKEYELCLRDIEFAQKMKYPGEMVYKILDRKARSLKALCRIEESKKVFEEAIVSSKTSKLKRKDRESWVKQVEKQISECSNQTENLMKSVTHLEEARSGFSTPVQNYGLHEKFVSISKALDIKYTEEKGRHTIAARDINIGDVLLVEKPFASVLLQEQSKSHCHQCFVHILAPLPCSYCTTVRYCSEKCAKESWDAYHYAECMNLEHVYVAGKYGHLALRVVVKAGFQYLKASVKQFESEEKKCDPAELGCNPDGVYDPSDYRPIYHLVGHTHERTLNDLFVRTLNAIYLLRCLEGTEYYGDSTKLPSREDQAFIGGLLLRHLQSLPCNAHEISELQLSLKSVATSEAAEIGAGIYGTLSLFNHSCEPNVTRFFYGDKCVVRAFSSIPCRGEVVDNYGILSALTPRKQRQESLQSQYYFKCNCHACLEDSPLYSELIKQDVPQLKCANCRMALAGEILTDGKLVKCEKCGVPQSLEDKANLLRKSEVEYNEAMTKLLGEADVSSALPRLEGHLRVLEECVCMPWQGFNSTQELMKQGYNMLANCHLIE
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLKHLTIQNFRNHEELSLDFDSRLIFFVGDNGEGKTNLLEAICILSWLKSFRESEDSNLIRWGSENYFLRGKIKDNLKESVLEIGFTSKPSVKRKLKFNQEEIKKRTDLIGKFITVLLTPMDLKIIEGGPAERRKFIDAFISSFDPFYLESLLEYNKILKHRNALLKSGNPDISHLSIWDKKIVEKGIFILNKRREVVLELNSFYRVNLDKLSGGKDGLELIYKPNVKDQDEFLEKLNHNLSRDLRLGYTSVGIHRDDLFIGSDQRDITEFGSQGQKRSTVIALKAATFNYYKNILNTIPVLLIDDVIRELDVKRREYFVDLVVTAGQAFFTTTDLEGIQDYVGKLKDQKQIFLIRQGKVESIK
The following text describes a protein:
Function:
Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways.
Sequence:
MASGSGIKRADSVADNMPDAMKPSRYHMKRCFTRFVAGGKRLMKRQQIMGEVEQSIEDMTERAQVLEGQLGFILSSTQEAAVVPPYVGLAVRLNPGIWEYVKVNASDLEVEGITAKEYLRFKETVFDENWANDDNALEIDFEAIDFTTPRMALPSSIGNGMNFVTKLMTSKLSKDSQSAKSFLEFLLALNHHGENLIINQNLNTVPKLQAALIAAEAFVSAFPKDEPVQKFEQRIKELGFEKGWGDTAERVKETMHTLSELLQALDSEKMDLFISRLPMIFNVVIFSPHGYFGQADVLGLPDTGGQVVYILDQVRALEEEMLLRIKQQGLAVKPNILVVTRLIPDAKNTKCDQELEPIVDTKHSYILRVPFKTSKGDVLRQWVSRFDIYPYLERFAQDAAAKIMDHMDCKPDLIIGNYSDGNLVASLMASKLGITQGTIAHALEKTKYEDSDVKWKELDPKYHFSCQFTADLIAMNQTDFVITSTYQEIAGSKTRPGQYESHTVFTMPGLCRVVSGINVFEPKFNIAAPGADQTVYFPYTQKQKRLTYFHPAIEELLYKEEDNNERLGFLADRKKPIIFSMARLDTVKNISGLTEWYGKNKRLRNLVNLVVVAGFFDPAKSKDREEIAEIKKMHALIEKYQLKGQFRWIAAQTDRYRNGELYRCIADTKGAFVQPALYEAFGLTVIEAMNCGLPTFATNQGGPAEIIVDGVSGFHIDPNNGDESSNKIADFFEKCKKGPEYWNTISTGGLQRIYECYTWKIYAKKLLNMGSMYGVWRHMNKQQKLAKTRYIQMMYNLHFRKLAKNVPIPTEEPQEQGAKVGSKPQKPTPEPGTVPSKGTPEPREEDIQEKPLASRIGNEITCPWNWWCLTMTFILISYYALSRLYFSESD
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
PKPAPKPLNSRPPWLGKEQKRKGLLLSQGCQEGDMAAAEPKSVKEALQEELTCSICLEVLADPVMIVGCGHNFCRLCLGRYWAGALRNVSCPQCRTAFPKARLEENRQLRNVAEVARRMASLRPKEGPLCALHQEPLNKGKGDHSCVVCHLSKYQPGLLLLNFQDQIGDAEKFKEEAKKSMKDMEVAAPSSQQERPEGEGGKAQPQYREEMELRIGIVKDKLLADVEEFCQFLKHQVQLLLPHLDVFQADLTKKVDETSSRYSMEIDQLNSLISDIEKTSNQPAIDLLKERAQRRLKIPLPVLLFLFVAMLFFVSILTHLLGEMAAALRRARAVWSSQPFSLTAMMYFDAVTAHNQLILSWGGRSVRVNQGSAEIKTFHKMRFDQVKCVLGTLAFMEGRHCWEIDIKDAEYWGVGVAKESVKRKTQVDPVEFSPKDGIWAIGCCNGKYAAFTYAAFTGCIDENPLSLCEPLKKIKVYLDYMAGEVSFRNSDTDTLIFVFPPAAFGREPIRPWFWLDNGQMSLPWPGEQYPVGGCQAF
The following text describes a protein:
Function:
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism.
Sequence:
MTYRVCFVCTGNICRSPMAEAVFRARVEDAGLGHLVEADSAGTGGWHEGEGADPRTEAVLADHGYGLDHAARQFQQSWFSRLDLVVALDAGHLRALRRLAPTERDAAKVRLLRSYDPAVAGGDLDVPDPYYGGRDGFEECLEMVEAASTGLLAAVREQVEGRAA
The following text describes a protein:
Function:
Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCFSPILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNNAVIHNSWIDPKRNKKITFEDSEIREKCLVPQVVTD
The following text describes a protein:
Function:
May play a role in the transport of fatty acids. Binds fatty acids and fatty acyl-CoAs including palmitic acid, oleic acid, cis-parinaric acid and palmitoyl-CoA (in vitro).
Miscellaneous:
MISCELLANEOUS: Expressed essentially in cells grown on palmitic acid with small amounts found in cells grown on glucose.
Subcellular Localization:
Peroxisome.
Sequence:
MSLKVDGFTSSIIFDVIRDGLNDPSQAKQKAESIKKANAIIVFNLKNKAGKTESWYLDLKNDGDVGKGNKSPKGDADIQLTLSDDHFQQLVEGKANAQRLFMTGKLKVKGNVMKAAAIEGILKNAQNNL
The following text describes a protein:
Function:
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
Subcellular Localization:
Cytoplasm. Rough endoplasmic reticulum.
Sequence:
MSQLQFQAPGNPAPSSAPLQLAPPQPGFSIPCGTAPLPSESASHPLRNSALPSASATPFCNPTVSNMANPKEKTPMCLVNELARYNKIQPEYKLLSEEGPAHSKIFSVRLTLGDQHWDAEGTSIKKAQHSAASSALAQTTLPKPSHRSPRHPGKSPGGIYKGSEYNVTHTVELNALCMKLGKKPIYKPIDAYQGMRPAFNYNIRAPSPYARSMQHYYYPFPPVGPVLYHMELSIGGQQFHGKGRTRQAAKHDAAAKAIKYLQKEPILQQITEMTDEPAQENLNKSEISQVFEIALKRNMPVDFEVLKEAGAPHMKSFVVRVVVGEFAGEGEGKSKKIAKKQAAIAVLEELRRLPQLPATDKIPLRIKKKSKSIIKLQTSPEYGQGMNPISRLAQIQQAKKEKEPEYTLVTERGLPRRREFVMQVSVAGQNAEGMGPSKKVAKRNAAEKMLELLGFKVPQPQPPKPALKTDEKPPAKKLGDGRKVTFFEPGSMEKAGLVVSKEEDFRLPFLSHQQLPAGILPMVPEVAQAVGANQGPHAKDYGRTAAPNPANATVTAMIANELLYAGTSPTAEGILKTNNSLAHRPQGPLTRPSEQLSYLANVQGLQVEYKDFPKNNKNEFVSLINCSSQPPLISHGIGKDVESCHDMAALNILKLLSELDQQSNERTANGPMSGCTKQDLEGDALLKPANSSTMGKTLDGTA
The following text describes a protein:
Function:
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon.
Sequence:
MYFLGLLSLLVLPSKAFKTNFPDETIAELSVNVYNQLRAAREDENILFCPLSIAIAMGMIELGAHGTTLKEIRHSLGFDSLKNGEEFTFLKDLSDMATTEESHYVLNMANSLYVQNGFHVSEKFLQLVKKYFKAEVENIDFSQSAAVATHINKWVENHTNNMIKDFVSSRDFSALTHLVLINAIYFKGNWKSQFRPENTRTFSFTKDDETEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMIVLSRQEVPLVTLEPLVKASLINEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKGLGITEVFSRSADLTAMSDNKELYLAKAFHKAFLEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFFFLVRNRRTGTVLFMGRVMHPEAMNTSGHDFEEL
The following text describes a protein:
Function:
Component of the endoplasmic reticulum quality control (ERQC) system involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M. Stabilizes the HRD1 ubiquitin-protein ligase. Also functions in recruiting misfolded protein substrates in conjunction with YOS9.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MITLLLYLCVICNAIVLIRADSIADPWPEARHLLNTIAKSRDPMKEAAMEPNADEFVGFYVPMDYSPRNEEKNYQSIWQNEITDSQRHIYELLVQSSEQFNNSEATYTLSQIHLWSQYNFPHNMTLAHKYLEKFNDLTHFTNHSAIFDLAVMYATGGCASGNDQTVIPQDSAKALLYYQRAAQLGNLKAKQVLAYKYYSGFNVPRNFHKSLVLYRDIAEQLRKSYSRDEWDIVFPYWESYNVRISDFESGLLGKGLNSVPSSTVRKRTTRPDIGSPFIAQVNGVQMTLQIEPMGRFAFNGNDGNINGDEDDEDASERRIIRIYYAALNDYKGTYSQSRNCERAKNLLELTYKEFQPHVDNLDPLQVFYYVRCLQLLGHMYFTGEGSSKPNIHMAEEILTTSLEISRRAQGPIGRACIDLGLINQYITNNISQAISYYMKAMKTQANNGIVEFQLSKLATSFPEEKIGDPFNLMETAYLNGFIPAIYEFAVMIESGMNSKSSVENTAYLFKTFVDKNEAIMAPKLRTAFAALINDRSEVALWAYSQLAEQGYETAQVSAAYLMYQLPYEFEDPPRTTDQRKTLAISYYTRAFKQGNIDAGVVAGDIYFQMQNYSKAMALYQGAALKYSIQAIWNLGYMHEHGLGVNRDFHLAKRYYDQVSEHDHRFYLASKLSVLKLHLKSWLTWITREKVNYWKPSSPLNPNEDTQHSKTSWYKQLTKILQRMRHKEDSDKAAEDSHKHRTVVQNGANHRGDDQEEASEILGFQMEDLVTMGCILGIFLLSILMSTLAARRGWNVRFNGAQLNANGNRQQEQQQQQQAQGPPGWDFNVQIFAI
The following text describes a protein:
Function:
Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the type II MazE-MazF toxin-antitoxin (TA) system which mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA.
Sequence:
MNQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHVFADSSAENSSEVLARWEQIKTEERAQKAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLGPVVDKVYEEIDEVMYEARQAVVDQAKLEEEMGDLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMTGVDLETMEEVWQQVKRQEIDL
The following text describes a protein:
Function:
Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKNIKFSLAWQILFAMVLGILLGSYLHYHSDSRDWLVVNLLSPAGDIFIHLIKMIVVPIVISTLVVGIAGVGDAKQLGRIGAKTIIYFEVITTVAIILGITLANVFQPGAGVDMSQLATVDISKYQSTTEAVQSSSHGIMGTILSLVPTNIVASMAKGEMLPIIFFSVLFGLGLSSLPATHREPLVTVFRSISETMFKVTHMVMRYAPVGVFALIAVTVANFGFSSLWPLAKLVLLVHFAILFFALVVLGIVARLCGLSVWILIRILKDELILAYSTASSESVLPRIIEKMEAYGAPVSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKWEHKFDRKKALAYEREVLGKFDKTADQ
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFFAKLQGSDSESSSGSESEESILSGSEGERQDKKLAAQKKQQKSKASMFLNSEESESEEESSDEDEEEMSDSDDERQAVANKFLNDAASSDEESEEEDKIIVLSAKDKRFAEMEAAIHSIQNAVKNTDWVLASSELDKLFRFIARHLVTIVASPIPAEGHIPPRFLETLVSLEADVAKTLAAEKSAPKKMAPAKAKAVNGIRQTLKKKSKEFDGVLKTYNEDPEAYTAAYEKANAAPAAPKPKKAAVTTPGEGEDDEFMTIGKGGKTLNLTADGVFKTLREIFEARGRKNTDRAETIKILTKLLEVSETTYQKIRVLLALVPARLDYSQHLVSIPQESWVTALQEFDQLISILIAEPDYLVQETVGEYDDLVERTPEVVDGKKQKVLIAGSLISLLESLDSELTKTLQHTDAHEKGDEYIDRLKHEAPLYTTIVKAQTLFEREQLSDNIARTVIRRLEHIYAKPDIIIEHFESKATQAAAGLKSEITPFDVKRDASGVIHDLAVFIYQSDAPVLRARAILYHIFNQALHGRYHQARDLLLMSHLQDTISHADVTTQILYNRAVMQVGLAAFRLGFIPECQTILSEMFSTLRQKELLAQSVQRYNIQLSPEQELLEKRRLLPFHMHLNVELLEAAYLTSCMLVEIPLLASVDTEEQRRRVTSKTFKRLLDMADRQAFMGPPENTRDHIIKASQALQAGEWEKARDLIVSIKVWSLLDNAAEVKDILAKKIQEEGLRTSLFTYAAYYDSLSLSHLASTFNLPVGRITSIISRMIYTDELAASLDQIDGVVIFHRVEQSEVQRLAQQLAERTASMLEQNEKTLDVKLGNQGQGQDRDTRAVGGEGGRQQGERRGGRGTYRGRGGRGGRGGFNQGLGTTMGRRVTAQ
The following text describes a protein:
Function:
Probable serine hydrolase. May be related to cell muscle hypertrophy.
Subcellular Localization:
Cytoplasm, perinuclear region. Peroxisome. Note=Concentrated in perinuclear vesicles. May be located in peroxisomes.
Sequence:
MGLHSELKLAVPWGHIALKVWGSQKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYNPGLPYYQQNFVSEVRRVATAFKWNQFTLLGHSFGGCVGGTFACMFPEMVDKLILLDSTPFFLDSNEMENILTYRRRNIEHTLQVEASQKKSLRAVSPEEMLQGFLNNNSHLDKDCGELILQRGTTKVDAGLVLNRDRRISWPENSFDFVSKEMFVHSAKSLQASVLMIKALQGYYDVRRANDADKAPMHFMVDTLRSTLKERFQFVEVPGNHYIHMNKPQVVAGVVGPFLQGLQRMTSARL
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEPQTTAKVVLTTTKGPIEAELFAKEVPLACTRFLQLCKSGYYDSKPFYRVLPGELIQCGQQEAGNNTNSYPKLKDEPHTRIKLKRGYLAMASEYTENNRRVPNSATTEFFIALKEIPFSGTVIGKITGDTIYNAQDIARGELTEDGYPMYVQTVQNVEIVLGGGLVQETQKAGADAGADAESRENKSGSRDRPKKPKRKLQVNHDDDDDEEPVFTKKSVSKLVEDKFKKDNTNVAKKPKVEASAEQPEPAAVQATTTHHVQDAEDMTTEVDTVVSERLEKFRNMSRTKPDTKPKSMLISQEDRIRRRLGLGPDEDIPSDASDPSSDEDDDFDIFKHKFICPEDDKAEDSLITLGA