lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVEYDAKGTESWFLKFTVLGQPFILAYKGCLTLKKAMKLKLALAGSQMANAGMYIKKTVQRATVESWSLGIQDTKDSTKISSFREFKVPKRRKWHIFNKKHIEVHGQRKVKKEVLSRDFGMEELEAEMISSGYEARGQKEVKNEVLRRYFTMKELEEEMASLGFGGPNNHFKDIILKLVLPHTLPRDLSREIRLQPIKSLIIHGPPGTGKTLVARRLAKILNAKLKVVRGPEIIGTLVGSGEKNLRDVFAPSIKDFEQMGDESPVHVIIFEEIDAIAGKRGVNMATDRIASQLSTLVDGVSRQTNLLLVGTTSRIELIDDGLLRLGRFGLRLRVDLPDEDARLKILQINSKRMQRWISFDSDIDLSAIASATQGLSIVDIEGLLQTALENALFRSSEGRHFKAEDIQIMKVDIQMALKGFGRDL
The following text describes a protein:
Function:
Irreversibly catalyzes the reduction of fumarate to succinate.
Sequence:
MLSSSSNNNNKIAIVIGSGLAGLAASSQLLSQDGDIQVHLLEQAARTGGNSIKASSGINGANTLFQLASNPPVEDSVERFYDDSVKSAGEVMRSNSGDGEERNARERLIRLLSEESKGAVEWLGAKGVDFSVVAQLGGHTIARTHRGGGKSKPPGAAIVGTLLEELKGNDRFRLKTSCKVVKVLQDAKNEAVMGVECIYEDQNVPPKTEKLIGPLIFATGGFAGDAYGMLAQYRPDLSGFPSTNDPRSGSQKLLTDIGAELIDMEKVQVHPTAFLDTKDINSPTKFLAAEMLRGEGGILLMGGRRFVDELDTRKVVTEKIMEYEEMKREKGKPRQWDVKLVIDEGIYEKTKSHVDFYLWKGLMKNGTISEANLGDEAVDTLQRYADAAAKKVTDDFGRKTFGYWKLGEVKSDSVIYVGRVTPAIHFTMGGVRIDEESRVLNTEKKVIPGVWAAGEVTGGIHGDNRLGGSSLLECVVFGRRAADGVLKSLVG
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
METKKKGEWCEITVPAKWNGISIESVLKVEWEIPKKLLHQLRMEKGVTVNGEQRRWNELLKENDKLQVHMFAEEEYGVDPEYGELHVVYEDDHVLIVNKPEQMDTHPAEKGGTGTLANLVAFHFQMQGLETKVRHIHRLDKDTTGGVVFAKHRIAGSIMDRLLMERKIKRTYAALVEGKVKKKQGKIDAAIGRDRHHATRRRISPKGDQAITYYKVEKYFKKQNTTFVTLQLETGRTHQIRVHMSHNGNPLVGDVLYGGQTKYMSSQALHAMKIHFLHPITKEAIEVDVPFPTKLNNKIKEFQKENA
The following text describes a protein:
Function:
Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium.
Subcellular Localization:
Periplasm.
Sequence:
MKIKSIRKAVLLLALLTSTSFAAGKNVNVEFRKGHSSAQYSGEIKGYDYDTYTFYAKKGQKVHVSISNEGADTYLFGPGIDDSVDLSRYSPELDSHGQYSLPASGKYELRVLQTRNDARKNKTKKYNVDIQIK
The following text describes a protein:
Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRFGGQRRCIESSDDNDSIDSMSIQQKNKEKEEWKWAQSLARRLEQVLNVHPEKYQNGCSSQRPSRQPSPVEQLAPIRSHSADFGRAAEMASGNSEEGKGMLLRNGDDRIRLPSPQRGTPDTSSTQGHPYTDQIVTINVSGMRFQTFESTLSRYPNSLLGDRNKRQHFFVSDTNEFFFDRHRTTSSSFTFEIRNYLFESILYIYQSGGRVKRPEIVPIDIFLKEMRFFQMGDDLLEEFWIAEGYEKPKEVMMPNNKTQRKIWELMEYPDSSLSARIIAFISIAVIALSIISFCWETVPSDIEEKPINNSATAELLDEMDEKHYSPFFWIELMCILWFTIELILRFISCPCKVTFATSVLNIIDFVAIAPFFVNFFFADTSKSNSSMSFAVLRVLRLVRVFRVFKLSRHSVGLQILGKTFRSSVQEFCLLIFFMAIALVLFASGMYFAEQGEPNSKFTSIPASFWFVLVTMTTVGYGDLVPLSPFGKVVGGMCAMIGVLTLALPVPIIVANFKHFYRQENRLASMKSKGDDADDDIA
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MAYPGFVENIASSLVREYLSRKECKNALEVMDSEMPRTEASIGNRSQLAKEVHIEKIMRKNKDATEPYRSMIEVIVKFLIERGSNSKDNSERVPEQRSSTDLSSPEKKSSPEKRSSQSSSRGKQKEKSEQKQQRVKSPKDKDTSPTEFTGLPQSDVSQGSLGREPTMVITMKDRPNVKPTDLQLAKDLQTSTSQKSASSDESRSKLISPSSSSSSSSSSLTRKMDDSGKKSSRPGSASKSRGLSGPITSSLDAGERRRGHKSSKTPALSLTATSKSATFEPEVSSSGFDLSPPKKTTSSSSRGLLKNFGFDLSPENTLGSMEAPGQASQGTSQGSGSEKTNGHPSSLSSSSTKPDRSSRHRRSFDDNSDVSRPGSRSGGSSRKGPSLDTPSVSSQKKEVSTLGDLEMGDVDELEDELGGIQLGSYTPSSKKPIDCRAITLQLAMQLKTLLFGQGTGCFNDEWRLQGLCFNELSDISYGIVQHKGGPCGLLASVQACMLQRLLFSEGSTPMTAANLKQLPEKTRIKCLVQAICDIVWRAGQKRNAVIALPAIKPHFPGGGRYKNDGLTEMINLNLFQSRDELADFVQGNIGTYTDSRGRGCILLLYSTLFSRTIDMVMEDMDNIENTLLGAHGYCTQEMVNLIVTGKAMSNVFNDTIELGSGRDITRLKGLSGRSDIGFLSLFEHYKSCQVGTYYKTPRFPIWVVCSESHFSVLFSLKKELIGDWRMERHFDLYYYDGLAKQQEEIRLTVDTTQTCPPADGDDLIPPLEHCIRTKWPEAVVNWNGSEPIL
The following text describes a protein:
Function:
May function redundantly with CYCLASE1 for normal plant growth, development and viability.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MAVPPLFFLLTLLSLPSLLISAGASNAYPSIPGTAPIDGGFTDELKPIRREVYGNGKIYDISHRYTPEMPSWDSSEGIGRFLWLAASMKNGSLANNSEMKIPTHTGTHVDSPGHVYDKYYDAGFDVDSLDLQVLNGLALLVDVPKDKNITAEVMKSLHIPKGVSRVLFRTLNTDRRLMFKKEFDTSYVGFMKDGAQWLVDNTDIKLVGIDYLSVAAYDDLIPSHLVFLKDRETILVEGLKLDGVKAGLYSVHCLPLRLVGAEGSPIRCILID
The following text describes a protein:
Function:
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
Sequence:
MARDLNKVMIIGRLGVDPELRYTASDAPVATFRVAASRQWRDQNGDLHDETEWFNVVAWNRLAEICHQYLSRGARVYIEGRLQTRTWEDAQSGQTRSRVEVIVQDMILLDQRPSRSDEPSRGPRREPPPDIGDDDIPF
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular Localization:
Nucleus.
Sequence:
MGVSFVSLFCLVSHYLSWLIDRYSTIVIISRVCTTFRFGLLTTLMPSRPPVHPYTSSSTSTGVHGHHNAAPHQLYKLFANLTFHIVPAKLEDDLARIYECIDELGGKCVGPEDAWVIVTALKGRQRLSRSLDQKWMETKQIVYVSYIFDTYQACLEHAVSPKTSTPKLPLRKNYLHVLSKEQSPIKISCRLDPGDPSISQPSTKRRKVNDGYVTAYRDDMTLLKEDVPLEGIPASCAQRPCPLVCINQDIVDAIKPIFEEREFEEAQQKNSNVLSYRRSLSMLKSVPRRITSGKEALSLQGVGEKVATRIDEFLQTGEIAESQEILASSRFNALQNFASVYTIGHFRAKELYERHHCRTLDDVKRHFADMEKDGEAKQGRGKDKRRMRGGMKEHEIVEEWMKLKNELDQKIPRKEVEEIAACVLDNLEAFIPGCEYTICGGYRRGKAQSSDVDIVFRPPKDDQDIGLLRALYLRLSELGIVTHVLQVTHRDSNQPIRAAAQNFDNLDKAFVIFKLPGEGRLHRRVDLISAPRDRYASAVLSWTGSMMFERDLKRYAENEKGHKFRAGLIKIATGEEINLETEREIFDYLGLRYIPPELRNADG
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MESLSIEKNSTPFGRSEYRTFNSELNYTLMDSSLNHSSILDNSMKIEKDSRDKRLQKLNQNIVSEYESGRQSVVFTQQKYKQLLEGFLLFVQTNKYIHQKITELRTEAIDEYNRMQNKNIPNIIIHQRLICNINNFQTGNEQFELLAKCLIKEPYLALPAYQAAIKELWKSEDSKVDIDPPKIGICGWLGRHHVTPRGLQSSMINKLVAVEGVVNKCSTVQPKLVQSVYIGEAVHDMNADAKTSEKTVHLRPHYDITDFDKTAKDSGRPPASDPEGRIMHKHEIGLCKYKNHQKFVIQETPEDAPTGQMPRWVEVIVEDDLCDIVKCGDRVRVWGVYRANCGQANSTNSGLGRSFLIANNVLVKNKETYDSNLCISEADKKNFHAFAKKDNTIDILGYSFAPSICGQDIVKKAIVLMLAGGTERALPSHHIRGDIHIMLVGDPSCGKSQLLRYVMSIMPGTVSATGRGSSGVGLTAAIVTDQDTGERVVEGGAMVMGDRRVVCIDEFDKMQPTDRVAIHEVMEQQTVTVAKAGIHTTLNARCTVLAAANPLYGCWNDALDMGQQLQFEPSLLSRFDLIFLVRDSATEQDDERIAESVLRNVTEKAKPIMNESRNNQKNFVIQADSYDINPKAQHISIYNERDINQNNDSNNMQENEEYETPIFANRDEMIYYDKNGVEHEILTVPFFKKYLHYVKNIFYHEKQRTDGWKPYPEVSDEACEVITELYADLRERASKYSHNKLIQGVTPRTLEAIIRIASSHAKLKLNRYVTSVDVNYAKKLLMYTLFGEEIIDSNEEDEEEDEEEEEEEEEEDELEEDEEDDDDEEEKLKKKRRQRQKRASRKRSGEKKDLASNKKKKKKSEQPNENGNENYMIDDLPSNKSNDTLDIKEIERLIVENVTLNDPGDGLKDVELLDLIILGNKDKMPELSKLDINQLRQIINSLNDMDGAPIYYVKKDKIVYKC
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
DILSDLPYTMEAVRRLLPELTTALRKGNCGRLGVVGGSVEYTGAPFYAAISMLKVGADLAHVFTPDDAAAVVKGYAPELIVHPELDPGHWQQRMDAMLVGPGLGREEKSLQVAHDVIVEAQRRAQPLVVDADGLVILTERWESLSAAPVHKAELPIILTPNAVEMDRLAMQVLQVSTLGKPWEEVRLAVSKLAARLKMNIFLKGPTDMFATADGKVRLYDAEGSARRPGGIGDILSGVIAVFLLWSTRSDVPLHTVAEAASFFVREAARRAHEQIGRGMTASDVVAQVAPLMKTIDKPYEGVYDANKL
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MFFGTMGRFNWSNTVIFALQWISIISKVTTAAGTFELRLNSFSNDQAKDINGQCCGNNTSTDQCVGPCRTYFTVCLLHFLREIPEEPLPGQCTFAFRNTSVLGENSFEVHDGLIQIDFDIDWPRDFSLALDAWHDESSTGFKDGNRRRLETLRIHRSLNVSTTWSNYTYPTSLHTLDYSYRVVCAETYYGSQCRDACIPKDDLFGHYLCDKDGGRVCMDGWEGNWCEHAVCSEGCVHGSCDSPNSCRCDNGYKGTACDQCETYAGCEQGTCTVPGECVCNVGWGGLLCERDLNYCTNQHPCMNGGTCRNEGPLGFQCYCLPSFTGHTCETAETCPCLNGGTCRSGSDGYTCLCPGGYTGDLCQTQVPRCDSNMCMNGSTCSETFDGYRCACQEGYTGTHCEIRDHCSSSPCRNGATCLNNNVAYQCRCPDGFRGDRCEENLCATHGCENGGTCRAESDSVHCECPRGFNGDHCQNNVNDCVASPCKNGGVCFDLVNDYRCECAFGFGGPNCSDHFTVCDGDNPCENGGTCLQDVMGGFMCECAEGWIGTTCTQSTGKEQTPKPSTDWQRGSQQPNLRATSSPITNFGLSDTMQLAIYVAFGLLVIVLVIILIIVVYRKQHHPDPRQNDLESNTTSTPNNRNRHTYKDNFSQEEKVLPLLSISEKVCNKEQDTYSKASQNTSSALQQKKTNHYSIKEYEGPPPSVNKLMIIPTSSSMNYAPQARQSFPRYDSEEYYYYDEKSVQLKRTDSLQTPSQSSSSQSTPRHTGTCPISQISAVVEDSRGTTTSTSVGLHATEV
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHRSNMKRKSSAKGTNITFKCPDKVLCVVVNRTSSTCIFRFPGDKVLFCLGPLHPIRRIAICVATNKYFEMFVMCTILINSLILSLSRPIPITDYVFMAIYTAEMAIRVVASGFIRRKHSYLRDMWNVIDFLVIFLAYATLFGDFSNLSGLRTFRILRALKTVSIIRGDTSSFEESYDPEPSGSQDFSLGINGLKQAVQALLKSMKMLLNVLTLILFCLIVIALFALQLYMGVLTNKCVRNLPTNVTNVTHDFYAAYTWNKTNWQPGREDWKFQVCGNVSGAGTCAENYTCLGDIDGNPDYTSFDNFGWGLLMSFELLTLDYFENVYDLVMRAYGPWNMIFFVAVTFFGSFYLVNLMLAVIAMTYQEQKRQDMERKRKMLETGEESWMLKFSRKPYEMWYILEGVKLIALTKERLSLLNMQIRQRFQKRKLAHLRKIAKSAGRQTVEAEETPPVEIPLVEQNSTENVASAEGGPRNCCVGPSHYTCITVEPPGSPLRHQNTNGYDMEYIKSTCSCHRDRSLQNQENNVPPASAILAMSAASTTSPNGEAEQGDSTDGKCCRALKIKKEKCVSFLFDYCCEWVCCTSSCWSKFQHYVDRVVSDPLFDFLIMICILINTGFLAVDHHGMSQSLAKTLDDGNKIFTAIFTAEVLLKMMAWTPKKYFQDYWNVFDCCIVFISLIEWGLEGVEGLSVLRSFRLARVTRVLKLAKSWPTMQLLLTIITNSIQDVGGLTFLLVVIIYIFSVLGMQMFGQDYKDNYLRLPGKEVPRWNFVDFHHSFMMVFRVLCGDWVKPLYDCMAVSGYGCVIMYVAALAVGNFVVLNLFVAMLLSSFASEELSSFENNTNSIQDGMKRLKEIFGLNGLFNSCRNPKKQKDDSVITVDRKNLLKYLHERTHTKLSLVSDKSDHSVQDCFPSVIMRLRCWKKFSMSKFGRYWAKFRLKTLKIVDNNIFEGFILVIILASSILLAFDDIYLDTRPTLQKVLAILDIIFALIFLIEMLLKWIAYGFVKYFTNGWCVLDCVVVAVGLPVSLFSIALESTTKSANLSAVRSLRVFRALRPLRAISRWQGMKVVVSALLHAVPAIFNVLLVCVVFWLIFGIMGVQLFSGQFFKCLDHEGERIPATLINDKTACVTGNFTWINSKVNFDNVGAALLALFQVATFQGWIEIMHDAVDVRGVDMQPSREANPYMYIYFVVFAIFGSFFTLNLFIGAIIDNFNSLKRKYEGEGYLDIFLTSNQKKYYNTLRKLSDKKPQKIVSRPKIRWRAAIFDFALSKEMEIAVMGAIGLNMVAMAIEHYHQTEVITHVLWVINLVFTGLFTLEAIVKLIGMGNQYFRLPWNVFDFCIVVLSILGFLLEDVLKSRFLTPTLLRVVRIFRIGRVLRLIRAAKGISRLLFALLISLPALFNICILLLIVMFIFSIMGMVSFTHVHHEGMLDEIVNFETFGRSMMLLFRLTTSAGWNDILEPLMKYCDTSEPDHDGLCSGTTIPALYLVSYIMVSSLIIRNMYIAVGLEGFNQAQEQKHVGITEDDFESFYMVWQRYDPDATQFIDYTLLTDLVDELDDPLRLRKPNNIKLQTLDIPLVSGDRVHCIDVLKELTTFTYKRLWGDVENTDEFGEIMDQMEDTFKKSFPTRVNEVVVTTTARREREFRAAVLIQRAFRNHQTAKWAELLKSFTIHETTV
The following text describes a protein:
Function:
Binds double-stranded DNA (dsDNA).
Sequence:
MALIMTQQNNPLHGITLQKLLTELVEHYGWEELSYMVNINCFKKDPSIKSSLKFLRKTDWARERVENIYLKLQRHKERNQ
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALEAICGMNKMPFMRRFDDVQSEWQKEQLREATSNFENPYELMAPPFERPAENLPKILSHCGIRMDFDHGTTTLGFKYRGGVILCADSRATSGQYIGSQTMRKIVELNDYMLGTLAGGAADCVYWDRVLAKECRLHQLRYRKRMTVDTAARIICNISTEYKGMGLVMGMMLAGFDDEGPKLIYVDSEGMRSHGQVFSVGSGSPYALGVLDTGYRYDLSDQEAYDLARRAIYHATSKDAYSGGIVRLYHIHSEGWRNICNTDCSDLHDSYCASGCPGNEKDVGNVGDPDNDKPCSSGWTKKNITADNLQTKLATV
The following text describes a protein:
Function:
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence:
MSDTEEVEQVEEEYEEEAQEEESQEQEEEPVVEEAPQVEEAYEEAEEEEHGEEYDEEKPKPKLTAPKIPDGEKVDFDDIQKKRQNKDLIELQSLIDTHFEARKKEEEDIIALKDRIEKRRAERAEQLRIRTEKEKERQTRLAEEKARREEQDLMRRAEDDMKKKKALSSMGATYSSYLAKADQKRGKKQTAREMKKKILADRRKPLNVDHMNDDKLREKAKEMWDWLYQLESEKFEMGEKLKKQKYEITTLRNRIDQLQKHSKKAAGGKGKVGGRWK
The following text describes a protein:
Function:
Transcriptional activator which binds to the C-box-like motif 5'-TGACGT-3' and A-box-like motif 5'-GTACGTA-3' of target promoters to positively regulate the expression of genes involved in the tricarboxylic acid (TCA) cycle in response to nitrogen starvation. May also regulate the TCA cycle during day-to-night transitions.
Subcellular Localization:
Nucleus.
Sequence:
MRFPAASVAVDSTPQLRLLQMKDSHETYSTVQLVHSPLPEKGPNSVLVDVPQQISRRKPTAEQSFVSGSDSSRSSTKSSSGSRPVMTTTADPNIVTAASTESVSSSPKWLPKKADTDDRVQRSRERNRIHARKTRQRKKEQMQSLEGRATDLKHEQIRLKQIINEKNTANILVGLFSKGQSQSPNEDPRVEALMYRSVEEIPDPSKIPELPALILPGQHASKKIKVAVPVVAASPQSMSDGGGEEVASTSDVSGDEQQVPDDGIDYDLLGKDRSKCTPEELDQIRRERNRMHAKRTRDRKRIFTEEMAEMCRILEEENHLLRVHLGGLDSDFKSESTTTSTHVVDRIDSVLSTPTLASCAPPQDMVSVSLSPSQLPSKPSTKEVAFNQLQTLLDVAGSFERQQREAERKVPQMCSISAASDTSTSDSSHHHRQRRCHKGDSDRPVKRQRYQVPRSITTTTSLAAPVGW
The following text describes a protein:
Function:
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression.
Subcellular Localization:
Nucleus.
Sequence:
MGANASNYPHSCSPRVGGNSQAQQTFIGTSSYSQQGYGCESKLYSLDHGYEKPQDKKKRTSGLATLKKKFIKRRKSNRSADHAKQMRELLSGWDVRDVNALVEEYEGTSALKELSLQASLARPEARTLQKDLADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDILVQLSEEFGTPNSLDVDMRGLFDYMCYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGEEITDRTLRTPTRIILDESIIPKKYAKVILHCMYTDVVDLSVLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDIIAESISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEHQLMKRIADREPNLLSGTAHSVNKRGVKRRDLDMEELREILSSLLPFVRIEHILPISSEVLSDAMKRGLISTPPSDMLPTTEGGKSNAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISHQQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERFGDESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAPKAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAAAGAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELSQSVSEAGPGPPQHLSCISQRHTHTSRKKHTLEQKTDSRENPQEYPDFYDFSNAACRPSTPAPSRRTPSPSQGGYFGPDLYSHNKASPSGLKSAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTSNRPSLSACSSEAPEERSSRRLADSESLGHGAQRNTDLEREDSISRGRRSPSKPDFLYKKSAL
The following text describes a protein:
Function:
Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
Sequence:
MPVPGADPAKKILKKKVVKKVVKKRKESVAEKAPAKDVAPKAEEKPVPDGIVEAPENATTTEGVEVTVRVKVMHIDVLHAMKVIWIKGKWKELTKGDRYDMWCNERTGEHFLKFRQPKVSDGGSYKVKAVSPIGENEASFNVAVGLFNISTAPVVEEHKIEINDEKDVLKDVDFRNRLKKVYTLKSIRCSERLRKEESSGKFDIWSLLKTASTRDYESIAFKFGIPDMRIMLRRLSQMSKLANKKCPSFTKKLPESHSLNLGEKLVLEAEVANEQMTVKWLKNGNEITPGKGYQIVTKANKRYLMIDQTSKDDDATYTCVVGKDVTACEVFVQEPPVTIVKGLEDAQIACGETTEFCCEISNENGKFRFLKDGVDIPSNDRFKVKKEGVKVTLTITEAVIEDEGFYQFMTNGSSSCSELLVQEPAAVFTRAFSDLKVNFKETAEFFCEVSNETTKGNWLKDGKPMKADDRVKITETGKARKLVISGVKDSDQGEYTFAAEDNPTCSITAALEMTGGHITVERKKAPPKIFLDHSLKDRSIQVRAGNKIKLDIPISGEPAPVPEWKKGPKLLEEGSSKLRVRSDTAPNGKRTSLIIDKSKRTDSGEYTLILTSEEGFESATFTVKVIDVPSAPTVPKVSNVTAETCYAVWTGPSCNGGCEIKGYVMERKKTKSERWIRLNFDPLQGVEYEARRMIEGTEYQLRVRAVNEVGVGEPSPASIPFTPLAPCSEPSGFKVSAATDDSLELSWLPPADIGAAGLDGYLLEQQLVGEEDEKWTTVQSNGGLLPNNTSKILMDKLVTGKKYRFRLAAINKAGSSGFTEIGPVVCAAVVEEAKIVLPRHLLKPVKVKVGGKLHVNVPYQGRPKPQLTWSKEGKALEDHVAVRNSLDSSVLFIRTAERWDSGKYDLQLKVGDDVVGAKVEVAVIDIPSKPRQVKLVEVVGNSASLKWEEPNDSGNTEILGYIVEKRDARSDDWYVVYDKLRHKQCQVSDLVLGNNYFFRVRAFNEVGTGESNGTKDSANIPKEKTVYKKPDYAPMDFRMKPEFTQLLNGRRIVENYNGTLSCALKCNPRPKIKWFKNKIEIIDNPKYKMTQSMGIVQLEIRRARAGDAGNYTVTAINELGEASCSAEVTVKE
The following text describes a protein:
Function:
Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
Subcellular Localization:
Cell projection, podosome. Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Sequence:
MSVAGLKKQFYKASQMVSEKVGGAEGTKLDDDFRDLERKVDVTSKAVAEVISKTSEYLQPNPASRAKLSMLNTMSKIRGQVKNPGYPQAEGLLGECMAKYGRELGEDTNFGGALVDVGESMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLREIQHHLKKLEGRRLDYDYKKKRQGKIPDEEIRQALEKFHESKDVAETSMYNLLETDIEQVSQLSALVDSQLQYHRQAVQVLEELSDKLRERMNEAQSRPRREYTPKPKPIFDFGDNSHSNGGYPTTMAPPPSRNPAPPEQPSCKALYDFEPENEGELGFHEGDVITLTNQIDENWYEGMLNGQSGFFPLNYVEVLVPLPH
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm-1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm-1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSIDLNWDTVTGGPDGQELAQKIRDFIHEKFQAVPLPRFIKSVTVHDFEFGSIPPEIELKDITDPLPDFYEEQPGIDSSEESDSEEEVAYENEGEYLDDPVEQQYGRLRGASASESRRRLTVNSSTGSRNGSGPNSGRVAYLPPHLNPHYNGGSGNNSSPSLDRDGRYYRDPNTAGLGGPAHGTNHHHADLGSPFLGVSTPGIPGGTSNLNLHYFTSQFTAGLSGTQTPLAAVAGAAHQRGPSWIADQQQQQQQQNNMLPGGAGGGGAGGGGMGGPVAAAAAAAAATNQGLHSSSTPHLRLHFPGVGTGKPTPGPSPLTGTSTPLGTLGTAGGVGGIGRGMGMAGMGSMASMGYPPTAPVLAIPTGPRHKRNPSSQSLNSVGDYSPVAPAPAERQGLFSAAAATSPPSSTPSPAVGLGIGGRGIGAAGAGAGALATSGPRLQIPKQGLREKHSVSTLAPNSAGTSNNRAGSAILDDDDGFLDGMHDHRDHPAQQQLEPEEDEEEEEEGEEERQRFREPRVEDIQAVFRIKYAGDVKLLLTADILLDYPMPSFVGIPVRLSITGLTFDGVGVVANIRKRVHFCFLSPEDAVAAVGGEENKAAGSGNGSGIGGGSDGAKTKMGGLLQEIRVESEIGQRESGKQSLKNVGKVERFVLEQVRRIFEEEFVYPSFWTFLV
The following text describes a protein:
Function:
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity). Probable chromatin remodeling factor. Probable helicase-like transcription factor involved in transcriptional gene silencing. Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin.
Miscellaneous:
MISCELLANEOUS: Induction by the mutagens rose Bengal (RB) and methyl methane sulfonate (MMS) is enhanced in progeny of Chernobyl plants exposed to ionizing radiation thus leading to a higher resistance to DNA damages.
Subcellular Localization:
Nucleus.
Sequence:
MKRDFDEISEEEWSQHSFNASRVLKRPRTPKKTRAATNPTPSIESFAFRRPSTAMTIESNSSDGDCVEIEDLGDSDSDVKIVNGEDLLLEDEEEVEETKVVMRAARVGRRFVIEDEEASDDDDDEAESSASEDEFGGGGGGSGGRRGEDEDVVGKALQKCAKISADLRKELYGTSSGVTDRYSEVETSTVRIVTQNDIDDACKAEDSDFQPILKPYQLVGVNFLLLLYKKGIEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVLQYHGAARAAYSRELNSLSKAGKPPPFNVLLVCYSLFERHSEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLMSVARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRRLKSDVMQQLVPKIQRVEYVLMERKQEDAYKEAIEEYRAASQARLVKLSSKSLNSLAKALPKRQISNYFTQFRKIANHPLLIRRIYSDEDVIRIARKLHPIGAFGFECSLDRVIEEVKGFNDFRIHQLLFQYGVNDTKGTLSDKHVMLSAKCRTLAELLPSMKKSGHRVLIFSQWTSMLDILEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKSIFACLLSTRAGGQGLNLTGADTVIIHDMDFNPQIDRQAEDRCHRIGQTKPVTIFRLVTKSTVDENIYEIAKRKLVLDAAVLESGVHVDDNGDTPEKTMGEILASLLMG
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin.
Sequence:
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEILATNTSATGDLDTLAGHCARTALDID
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for normal morphology and function of ciliated amphid sensory neurons.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, dendrite. Perikaryon. Note=Highly expressed in the transition zones between the cilium basal body and the dendrites.
Sequence:
MSSETTAPMIINEKSSLPVKSEPGQLGNPISDESSEDEQSQIRALEEDQGIYYNEEVVASPKNESDDDIPLRRIQLSHQTSTQQHPEDSEPQEVIDVNDIELPAGEAQPNMERRRSVRFSGRHDEEEDGRNKHFRTPSPESLRYIQALENPMAANGEFEEEFNDLADPQVQPPPMGSPPAYTSADEGPKTPPPRASAGSNMRQESMNELIMRKISDPLQNLIRRASRLEDDSSNDDDDDDDDEDDDYTEDEIAILTYIDAYKTQEVELRPQLRPFTIEYIPAMGDVDLFIKVPRPDEIDDNVGLTQIDEPPSNQSDATIVDMQIRNATKDAAILDDDVPVKLLERADENPDEIKKWISDIKEFHKSKPAQTVHYRTQLPDVETLMQEWPQKLEEVLKTTKIPSAELDVSLEKYVEICLNIVDIPVGKSRIEALHLMFSLLNEFNNSQHFRNLAQNNNLGGETGETMDRLEL
The following text describes a protein:
Function:
Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of the sperm tail.
Sequence:
MSEKHKWWQQVENIDITHLGPKRKAYELLGRHEEQVLINRRDVMEKKDAWDVQEFITQMYIKQLLRHPAFQLLLAFLLLSNAITIALRTNSYLGQKHYELFSTIDDIVLTILICEVLLGWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLDMVAITYPLRVLRLVHVCMAVEPLARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAFVPKHFQNMGVALYTLFICITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVFITLGAFIGLNLFVVVVTTNLEQMMKTGEEEGHLNIKFTETEEDEDWTDELPLVHCTEARKDTSTVPKEPLVGGPLSNLTEKTCDNFCLVLEAIQENLMEYKEIREELNMIVEEVSSIRFNQEQQNVILHKYTSKSATFLSEPPEGANKQDLITALVSREKVSDSNINMVNKHKFSH