lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Negatively regulates the septation initiation network (SIN) pathway, independently of the cdc14 phosphatase clp1. May also have a role in silencing rDNA transcription. Required for maintaining the exclusive nucleolus localization of nuc1.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Note=In late anaphase, localizes to the ends of the mitotic spindle.
Sequence:
MRTTLRLHIIKDGEQDNQFMILFDPSSSISLLKEKVQETYKSLYPFESNINIRNIKNEESYDIPNEYLVGEIFPTNSKVIVESFSSPLKKLDGTMINFKEKNIQHDLDGVENDFATVQSASNGVHAINGKRTHPDESENPRKLPKKNFVEAIDANSPGFVYRPTSIRDRAYSISSNHDNESTLTEGIALKEIESPDKDRKADGIVNLSVTQEEDDNHQSFNSSLTPSQPTTYNRANFFSINDASSDSSSDAPLRTLSSPSRLRMKDNDRKYLVEHSPAALIKESETIDGIDDKSLRSSTREVSVESPNEDSVNDDSSSDVSDEKETEAKHEIRAPAIIVRETSSHPSTAVPSENDTTESENDTLSESSTTSISSSPSENSDTSDDLTKVDSPNKSLVNDNVSAKHDKESENGKSKFPPPSQTLVTTSTISAAGNEPSDEIGSENDSDSDSDSDSSVPLSQLQKKSQQRNSVSHEIQNRGTKGSPKEPKAKPSTERPETHRTLSYSRLSELSKTFSPEIREPSLTKKTAVSMQESKEEGRSDESSESEESGSSSDESDNSEKEDRSNPIPVEKRASTVLNTKKKRKAKRNSALAGLAALV
The following text describes a protein:
Function:
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
Sequence:
MAADANHRKVVVNFQSVANAPKLRQSKFKVRALFSRRCLPHATSKLRNTPQIGGNEKFARVIEFLRCQIHQDTVFLYVNSAFSPNPDELISDLYNVRSNTLTTFICPLQS
The following text describes a protein:
Function:
Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Sequence:
MREIHSVLRCRQLLRSHRRFYGLAASKQMKNAAEGRPKKIKFFVGSQRSNVEALKREKHLENSPGWIEAFCSQKENDLFVRVDTDFIRDQFNLHGLSNEVLDYHGSLRDILETYRGYFDEEAQKLYGLIHRRYILSTKGLEAMARKFKHEEFEKCPRSCCEDQTCLPVGLSDDPGVSTVRFFCPRCEDVFDPIAVQHRSVDGAYFGPTFAHLLLLTHPMEIKPCVKHPSSSGYVPRIFGFKIHKPSASSDDMEVA
The following text describes a protein:
Function:
Synthesis and degradation of fructose 2,6-bisphosphate.
Sequence:
MSRELGELTQTPLQKIWIPHTSNRLQQRRGSSVPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVQSYKNYEFFRPDNKEAMMIRKQCALAALNDVHEYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPDIIEENITQVKLTSPDYKDCDRDKVVEDFLKRIECYQITYQPLDDELDSSLSYIKIFDVGNRYLVNRVQDHVQSRTVYYLMNIHITPRSIYLCRHGESELNLKGRIGGDSGLSSRGKQYAYALANFIQSQDIAALKVWTSHMKRTIQTAEALHVPYEQWKALNEIDAGVCEEMTYEEIQEHHPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSAEELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHRERPENVDITREPEEALDTVPAHY
The following text describes a protein:
Function:
Involved, directly or indirectly, in the processing of chloroplast encoded mRNAs. Exhibits sequence-specific RNA binding and RNA remodeling activities, probably leading to the activation of translation of the target gene cluster psbB-psbT-psbH-petB-petD. Blocks 5'-3' and 3'-5' exoribonucleases (e.g. polynucleotide phosphorylase (PNPase), RNase R) in vitro. Necessary for intercistronic RNA processing of the psbH 5' untranslated region or the stabilization of 5' processed psbH RNAs. Also required for the synthesis of psbB.
Subcellular Localization:
Plastid, chloroplast. Plastid, chloroplast membrane; Peripheral membrane protein; Stromal side. Plastid, chloroplast stroma.
Sequence:
MHFFFVPNSSSSSPSPANTSSFSLSFLTPQIPENLCKSPTKIHIGTHGISGQSFLSHPTFSSKNTYLYAVVDRSSSGVFSPQKESANGEGEESNTEEGVLVVRRPLLENSDKESSEEEGKKYPARIDAGLSNIAKKMPIFEPERSESSSSSSAAAAARAQERPLAVNLDLSLYKAKVLARNFRYKDAEKILEKCIAYWPEDGRPYVALGKILSKQSKLAEARILYEKGCQSTQGENSYIWQCWAVLENRLGNVRRARELFDAATVADKKHVAAWHGWANLEIKQGNISKARNLLAKGLKFCGRNEYIYQTLALLEAKAGRYEQARYLFKQATICNSRSCASWLAWAQLEIQQERYPAARKLFEKAVQASPKNRFAWHVWGVFEAGVGNVERGRKLLKIGHALNPRDPVLLQSLGLLEYKHSSANLARALLRRASELDPRHQPVWIAWGWMEWKEGNTTTARELYQRALSIDANTESASRCLQAWGVLEQRAGNLSAARRLFRSSLNINSQSYVTWMTWAQLEEDQGDTERAEEIRNLYFQQRTEVVDDASWVTGFLDIIDPALDTVKRLLNFGQNNDNNRLTTTLRNMNRTKDSQSNQQPESSAGREDIETGSGFNLDVFLRSKLSLDPLKLDVNLDSKRLERFTRGRINGA
The following text describes a protein:
Function:
Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MACRYPFSPAKVAITRFFYPSPLSRSTTPLFCPPSCRIRVGNTSRMLTSSSSVASEDPKSEMAKFLASPNPKSSASEPGPSPHDVLSAPTSAGHISEAEETLSDQLRNPGSSSSSSPSQSSTNNLSSKNAPFKLSSTYSLPSNISVPPEVREHLIEWSKNVLEHSRYVIQEAQKKFVGLGLKVNEMTGYQEVERLKYMVFEKEDELQRLREHARTAKAAYDEAVAARSEAQRETNILLERKHSWTDADVSKFTSLVRSDHTSSHAVASTSIALKDAEIAVDKSFSQLMQVILQRYHEEQVWSDKIRSVSTWANVAGLAINFIIFVGAVLLVEPWKRKRLVEKLEERVASMMERVDHRLEGVEGHLERVAAGSASASAIKEQHSDAAIQGVEDMPSNSTANPLEFVSPQTIPLMAAVDPTINGSESQSDPFFTQTIRGFPNYLDPLVKPSQKRDLAVAGMAGAVAAWILIGAVRLVRA
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MSGKALNIGDQFPNFTAETSEGRIDFYDWMQDSWAILFSHPADFTPVCTTELSRVAALIPEFQKRGVKPIALSCDTVESHKGWIEDIKSFGKLSSFDYPIIADDKRELALKFNMLDKDEINAEGIPLTCRAVFVVDDKKKLRLSILYPATTGRNFDEILRVIDSLQLTQTKSVATPADWKQGGKCMVLPTVKAEDVPKLFPDGIETIELPSGKSYLRITPQP
The following text describes a protein:
Function:
Forms an activated complex with GTP-bound Ras-like cdc42. Participates in Ras-dependent morphological control and mating response pathways.
Sequence:
MLLSVRGVPVEIPSLKDTKKSKGIIRSGWVMLKEDKMKYLPWTKKWLVLSSNSLSIYKGSKSESAQVTLLLKDIQKVERSKSRTFCFKLRFKSSTKNFEIQACELSVADNMECYEWMDLISSRALASKVSSPMNPKHQVHVGIDNEGNYVGLPKEWILLLQSSSITKQECMEEPKAVIQALDFYSKQLDTTSETKDSFSFCKETLPRSSTTSYSIRDADKHHKLTTSGVTKMNITERCKPKTTIQTDKKHIIRPFIEDKSHVESIMTGKVTKVPVKADSKNTLSRRMTDRQALAMLKDSVTSHDPVEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNEITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSKLTEAQIARICLETCKGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTIDTIFRATAAELLTHSFLNQACPTEDLKSIIFSRKANTHIN
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity; Acts as an endonuclease, a 3'-5'exonuclease, and an ATP-dependent dsDNA helicase. Anneals and unwinds R-loops (in which crRNA binds the target DNA, displacing the noncomplementary strand). Unwinding requires ATP, annealing does not. Required along with the Cascade complex for resistance to bacteriophage lambda infection as well as the ability to cure CRISPR-encoding high-copy number plasmid. A Cas3-CasA fusion protein purified with the Cascade complex nicks target plasmid in the presence but not absence of Mg(2+), and degrades plasmid fully in the presence of Mg(2+) and ATP, suggesting the helicase activity is required for complete degradation.
Domain:
Proteins of this family have an N-terminal nuclease domain and a C-terminal helicase/ATPase domain. In some CRISPR/Cas systems the domains are swapped, in others they are encoded separately.
Sequence:
MEPFKYICHYWGKSSKSLTKGNDIHLLIYHCLDVAAVADCWWDQSVVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFDIRFQYKSAESWLKLNPATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLSEQSLGDFFSFFDAAPHPYESWFPWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDCSSLLAGFCSLADWLGSWTTTNTFLFNEDAPSDINALRTYFQDRQQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPVAPGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSPNLILAHGNSRFNHLFQSIKSRAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHTDPVENNSAYPLINWRGVNGAQRFDLLAHPEQLPPRFSIQPEPICLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQVDIDLFHARFTLNDRREKENRVISNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRPAGFEIPVATILLPDGEGYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMDEPEWVGNGMDKFESAECEKRFKARKVLQWAEEYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTWKRSFSEVVDEDGLLWLEGKQNLDGWVWQGNSIVITYTGDEGMTRVIPANPK
The following text describes a protein:
Function:
Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MAKHVVVIGGGVGGIATAYNLRNLMPDLKITLISDRPYFGFTPAFPHLAMGWRKFEDISVPLAPLLPKFNIEFINEKAESIDPDANTVTTQSGKKIEYDYLVIATGPKLVFGAEGQEENSTSICTAEHALETQKKLQELYANPGPVVIGAIPGVSCFGPAYEFALMLHYELKKRGIRYKVPMTFITSEPYLGHFGVGGIGASKRLVEDLFAERNIDWIANVAVKAIEPDKVIYEDLNGNTHEVPAKFTMFMPSFQGPEVVASAGDKVANPANKMVIVNRCFQNPTYKNIFGVGVVTAIPPIEKTPIPTGVPKTGMMIEQMAMAVAHNIVNDIRNNPDKYAPRLSAICIADFGEDAGFFFADPVIPPRERVITKMGKWAHYFKTAFEKYFLWKVRNGNIAPSFEEKVLEIFLKVHPIELCKDCEGAPGSRC
The following text describes a protein:
Function:
Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles. Shuttles between centrioles and the cytoplasm throughout the cell cycle. Requires zyg-1 and dephosphorylation by the PP2A complex for centriole localization.
Sequence:
MNNYDDLPCSIYFKKPTVQEFVDQPRVFEDSEVPAFQEVLQLPQERTKPPVPSTQPIVAAVEVAKKKSCLSAPKPRKEPPSHPALRQKTVAFGKTVNVSQTVEGTSRNSKKVLASTMSAQNTTTTEEQAAENWRDAMKTELQTIRTEIQEETARRQEELNAQNLVKMQELMSNFFQKITIPKQQAIEPVEKDKENFHESPRQSRQQKPASKIASAREVIKRDGVIPPEALTIIEQRLRSDPMFRQQIDNVLADAECDANRAAYSPPPPMSEVRYGSGVNPALMRETLTVERSIRYDNGLASIDSRQWTNERRDNRAPDSYRTYEPDQPCHSLYQKGQSISYYPSEAAGKTTARNNRTGYYVEDSSDHEEDVVVNKRGQNYHEQAVPETPAERERRIREKYARRK
The following text describes a protein:
Function:
Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways. Directly binds to 5'-ATTGAT-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development. Associates with condensed DNA during mitosis.
Subcellular Localization:
Nucleus. Chromosome. Note=During mitosis, localizes to metaphase and anaphase chromosomes. In the hermaphrodite gonads, localizes to the nucleus from late pachytene to diakinesis. Localizes to condensed diakinetic chromosomes.
Sequence:
MDFSNTYRNYGEVVDFPEDFLSDYVPTVKSEPEPAAIAPSVCEPPISTTRNYGTDFGRASSMCGSSSSSSSSSYSSGSSPNYLTENGGDTEEPRFEELVSRKMSFDSENVAQVSNQMDYARDTYADSRIPFASIDSNDALLPYPVNNYVAALPVPVPAKKSRGRTAPRTPKSLETSKPGRGVKRPASKEIDAKDLGIGDLSAHMNRQIGDDEELDTQLIAHRILDELKEQCIPQASLAVKVLGRSQGTLSDLLRKPKPWGIMKNGRGTFQRMANWLDLDPVVRRALCFMKKEDVARITGMAEPTPAKRARQTTPSDERIRRFTFTQTQLDSLHTVFQQQDRPNREMQQALSATLKLNRSTVGNFFMNARRRLPKAAPVSQNLVAEHAIDHNQPGPSHHY
The following text describes a protein:
Function:
The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging 'pac' sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities (Probable). Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. Once the capsid is packaged with the DNA (headful packaging), the terminase cleaves the viral genome concatemer and is substituted by the tail (Probable).
Domain:
The ATPase region is in the N-terminus, whereas the nuclease region is in the C-terminus.
Sequence:
MELDAILDNLSDEEQIELLELLEEEENYRNTHLLYEFAPYSKQREFIDAGHDYPERCFMAGNQLGKSFTGAAEVAFHLTGRYPGTKGYPADGKYGGEWKGKRFYEPVVFWIGGETNETVTKTTQRILCGRIEENDEPGYGSIPKEDIISWKKSPFFPNLVDHLLVKHHTADGVEDGISICYFKPYSQGRARWQGDTIHGVWFDEEPPYSIYGEGLTRTNKYGQFSILTFTPLMGMSDVVTKFLKNPSKSQKVVNMTIYDAEHYTDEQKEQIIASYPEHEREARARGIPTMGSGRIFQIPEETIKCQPFECPDHFYVIDAQDFGWNHPQAHIQLWWDKDADVFYLARVWKKSENTAVQAWGAVKSWANKIPVAWPHDGHQHEKGGGEQLKTQYADAGFSMLPDHATFPDGGNSVESGISELRDLMLEGRFKVFNTCEPFFEEFRLYHRDENGKIVKTNDDVLDATRYGYMMRRFARMMRDIRKPKEKKIPAPIRPVRRGR
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus. Chromosome. Note=Localizes to condensed chromosomes in mitosis.
Sequence:
MGKIKKIQRKGPPATKRPPKAARTESTDSALGLDAHSDLEKPATSSDDGFEEPTPKPKPSKKTTTLPEPVSIIAQKKNKFRTDDAKNVKPPTLEEMKELRDTRNLFHSNLFKLQVKEMLEELQLKTKYTEYIDNWMESFTVFTQRLKDGLVEKSQLEVPLNVDKKISGFIFSKPTKEPQLIGAASTGTLLGPKIVVDVALEMPKDCLHKDDYLNLIYDQKRALYLTYVTNQMRSDPAYSQDKFAFNYHGNNPLKPVLELTPAAKHVSKHLQLRLFITAPQSTFKPGRFVPWNNNIRPTYYNDEWDEEEALPSTQHYNASVLFDLTLAQNQALLDKAFKGRRNFQDGLLLLKVWLRQRELDRGFTGFGSHILASFIVYLNQQRILHQSSSSYQVARTVWNQLANTDWTNGITLAPASGQTEQLSTIAGYYDVCFMDVSGQLNLCANVPLGVYQRVRAEAKLAVDLLNDMKLNSFPYIFMQKCPLYTRVDNILKITNYSSIQQMLVLHSKPQMKYDFASYGYPQLLQILTELLQKGLKQRVQAILPIETVSSAWPVESKAPIIGQAIQLGLILDPEHAYEVLDKGPSSNDDPEGSAEFRKFWGEKSNLRRFQDGSITEAVVWGTTKDAPSKKRLIVRQIVMHLLEHHLQLDSKDIQYIAAELDLVYQLSPWFKVSKVKTKLELQQDTDAEALSPNVIRCYDDLARQLHALDDLPLEIVSISSISPVSRYCEPMPVLPQARMMADHIHASHIQRVIIQLGQSGKWPNELSALRALKTAFLIEIGEKLKAQCRLNWSITSEGLLVLKRGFCFLLELAHNKELALLKQEVTERGVTKYVDNPESRALEQRHYILPKVSGALHSLHQSHSAYGPTVLIAKRWLATQLLDDGIWPPMATELLVAHLYQQRNAPQAIAAPQTGFMRLLHLLAHSDWNGELFLLNFNSSWQEQQIGDLEHSFRSDRQSYPPLALATSYDQQHAGRLWTTGESPSLRILSHVSRLARHALEMIETSLQSKDLRFVRPAQLFRGSSEGYDLVIQLKSDLVPNALSYDLGSPFVSFDQPNYLLPRAGKDPLAAIVHQLRSAYSDYAAFFYNPHGGKELAIMWRPPAVFAPKAFKVTELQACTLCDKGKVQVVRETLVEDFKVLLKDFYLRISTPEELKREQREHQNPKRYFNAKPQDNESCSKSKKRKLAKAAKVQAPLKRKSLIKSRPLKSLS
The following text describes a protein:
Function:
Outwardly rectifying potassium channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTRFMNSFAKQTLGYGNMATVEQESSAQAVDSHSNNTPKQAKGVLAEELKDALRFRDERVSIINAEPSSTLFVFWFVVSCYFPVITACLGPVANTISIACVVEKWRSLKNNSVVTNPRSNDTDVLMNQVKTVFDPPGIFAVNIISLVLGFTSNIILMLHFSKKLTYLKSQLINITGWTIAGGMLLVDVIVCSLNDMPSIYSKTIGFWFACISSGLYLVCTIILTIHFIGYKLGKYPPTFNLLPNERSIMAYTVLLSLWLIWGAGMFSGLLHITYGNALYFCTVSLLTVGLGDILPKSVGAKIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGPIFFFHRVEKGRSKSWKHYMDSSKNLSEREAFDLMKCIRQTASRKQHWFSLSVTIAIFMAFWLLGALVFKFAENWSYFNCIYFCFLCLLTIGYGDYAPRTGAGRAFFVIWALGAVPLMGAILSTVGDLLFDISTSLDIKIGESFNNKVKSIVFNGRQRALSFMVNTGEIFEESDTADGDLEENTTSSQSSQISEFNDNNSEENDSGVTSPPASLQESFSSLSKASSPEGILPLEYVSSAEYALQDSGTCNLRNLQELLKAVKKLHRICLADKDYTLSFSDWSYIHKLHLRNITDIEEYTRGPEFWISPDTPLKFPLNEPHFAFMMLFKNIEELVGNLVEDEELYKVISKRKFLGEHRKTL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MATTFLRNLFSQAQPSLLRRPLMPSSSSILPAAARLFSSTPAQNATLNQVMRGCRKPQRARHAVSPALSSIKSPALKGVCVKVGITRPKKPNSGERKTARVRLSTGKVITAYIPGEGHNISQHSVVLVRGGRAQDCPGVRYHLVRGALDLAGVATRMSSRSKYGTKKPKKASVG
The following text describes a protein:
Function:
Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Sequence:
MAALSPFTQKNLLIAAKPNTLDFNLNTQTPQCTIVLQNISKQRIAWRLQTNSPTRYFISPSCGFLTVNEAFPVTITLVSSKRFHERHRFMLTAAVAGEMSKNRKEFWSNPIDFSHLHCVRITPLCAETCKSPVVSPNSVISPTASTAVSPSGTNTAVSGSPGIGGGLSSLEGKIVTSPRMTSPRASAEKPSAESVDNAASGSSSARVDSSGLVNEIRCLVASKEEGTRKMLEAVNNVKKLEMELDKVAVTSRQYKMQFARVMETLNEKRTRAVILQEQIRAAKARVLLSSLSMWKSSSPSRAKGQNGRSNSLISLRSNSLLQRAVSLQFLNRGNREKQKSEIAKIRLRYSDTARSVIWPHCRYVIDEKTRLNQKKAAPLAEGGDRLSQKFLPVEMEDHRSPYPPCAINRVLRSDSEDSEDDIDQMTRL
The following text describes a protein:
Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.
Sequence:
IKRKASYLEQPLNKRFRGNPAEEDNPKLRFEAKYVELHPLGEGGCGSVFAGYRRSDHLDVAIKHVPNKYQYCKHVDEEGRELSGEVAVMLKLRSGTSHSPSSRAPIALLDWYVLPHELILVLERPMPAVDLQTYVEECRDTFGEKEAKMILKQLVKAAISLQDKKIFHRDIKVENILIDMSSGAPQVRLIDFGVSCFTETHSEYTTFYGTEIHAPPEWWYEHTYSARPTTVWQLGIVLFECLHNKNFSSTKLMEKKLQLRQNLSKDCKDFMKQCFIQNPRRRPSLEQILLHPWLK
The following text describes a protein:
Function:
Component of the viral DNA-dependent RNA polymerase that catalyzes two reactions involved in viral RNA cap formation: an RNA 5'-triphosphatase that hydrolyzes the gamma phosphate of triphosphate-terminated RNA and a guanylyltransferase that reacts with GTP to form a covalent protein-guanylate adduct. Therefore plays an essential role in late and very late gene expression.
Miscellaneous:
MISCELLANEOUS: Tpase and GTAse regions, and GTase active site inferred by structural homology with vaccinia virus TPase/GTase family.
Subcellular Localization:
Host cytoplasm. Host nucleus. Note=Preferentially in the host nucleus and associated with the virogenic stroma.
Sequence:
MDYGDFVIEKEISYSINFSQDLLYKILNSYIVPNYSLAQQYFDLYDENGFRTRIPIQSACNNIISSVKKTNSKHKKFVYWPKDTNALVPLVWRESKEIKLPYKTLSHNLSKIIKVYVYQHDKIEIKFEHVYFSKSDIDLFDSTMANKISKLLTLLENGDASETLQNSQVGSDEILARIRLEYEFDDDAPDDAQLNVMCNIIADMEALTDAQNISPFVPLTTLIDKMAPRKFEREQKIVYGDDAFDNASVKKWALKLDGMRGRGLFMRNFCIIQTDDMQFYKTKMANLFALNNIVAFQCEVMDKQKIYITDLLQVFKYKYNNRTQYECGVNASYAIDPVTAIECINYMNNNVQSVTLTDTCPAIELRFQQFFDPPLQQSNYMTVSVDGYVVLDTELRYVKYKWMPTTELEYDAVNKSFNTLNGPLNGLMILTDLPELLHENIYECVITDTTINVLKHRRDRIVPN
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Can process efficiently 4,6-diamino-5-formamidopyrimidine (FapyA), 2,6-diamino-4- hydroxy-5-formamidopyrimidine (FapyG) and the further oxidation products of 8-oxoguanine (8-oxoG), such as guanidinohydantoin and spiroiminodihydantoin. Has marginal activity towards 8-oxoG. Has AP (apurinic/apyrimidinic) lyase activity. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Subcellular Localization:
Nucleus.
Sequence:
MPELPEVEAARRAIEENCLGKKIKRVIIADDNKVIHGISPSDFQTSILGKTIISARRKGKNLWLELDSPPFPSFQFGMAGAIYIKGVAVTKYKRSAVKDSEEWPSKYSKFFVELDDGLELSFTDKRRFAKVRLLANPTSVSPISELGPDALLEPMTVDEFAESLAKKKITIKPLLLDQGYISGIGNWIADEVLYQARIHPLQTASSLSKEQCEALHTSIKEVIEKAVEVDADSSQFPSYWIFHNREKKPGKAFVDGKKIDFITAGGRTTAYVPELQKLYGKDAEKAAKVRPAKRGVKPKEDDGDGEEDEQETEKEDESAKSKKGQKPRGGRGKKPASKTKTEESDDDGDDSEAEEEVVKPKGRGTKPAIKRKSEEKATSQAGKKPKGRKS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
Subcellular Localization:
Lysosome.
Sequence:
MRASIIVVIGLVCLLVPAAALDNGLALTPTMGWLHWERFMCNTDCDADPQNCIREELFMQMADVMVKEGWKDAGYEFVCIDDCWPSQQRDAQGRLQADPKRFPSGIKKLADYVHSKGLKLGIYADVGTKTCAGYPGSLGYYDIDAKTFADWGVDLLKFDGCFMPDWHQLGEGYINMSSALNQTGRSIVYSCEWPLYEWQHQQPDYEAIRKTCNHWRNYGDVYDQWTSVKSILDWTAEKQKIVVPVAGPGGWNDPDMLIIGNFGLSRDQQQTQMALWAIMAAPLLMSNDLRDICPKAKELLQNKQIIAINQDPLGKQGYRILKADSFELWERPLSGNRLAVAVMNRQEIGGPRRFTISVAIMPSWKLCNPKCNVTQIMPTYKEMGVQNLLSEVVVQVNPTGTTLLTVNPL
The following text describes a protein:
Function:
Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MTITSAPGKLILFGEHAVVYGAQAVAAAVSLRTYCFTEHVSEPILKVTLADAHTTASWSLADLPWSLVPKIDVNKAPKSLDQKLVKGVHSLLECYVTNPLIHSAFFCILYMYMFLGSSSEGTAIVIRSNVPLGAGLGSSATVSVSVASALLLNKGVLSFPSNPSSKDSNSPTQAASTTVDGHTASQTSQCTSPGPSDSGRLIEAWSFVGECCIHGNPSGIDNAVATHGGVVTFTKSTSSQPSRMQVLQGVTSLPIMITDTKQPKSTKQLVQNVAKLVQDMPAPMRALMATIDSVSKSAVELLCSRQLAREQLLPKIGQLVELNQKLLECLHVSHPTLERVIDAAKRIGWTKLTGAGGGGCAYTVLRGADIEDDVNEVIEQLRSLGNETYAVELGGPGAAVWVAPIDEKTSTQTDAFFTRIQQSDQSWAYWS
The following text describes a protein:
Function:
Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Recycling endosome. Endoplasmic reticulum membrane.
Sequence:
MEPRAAAAGEPEPPAASSSFQARLWKNLQLGVGRSKGGGGGRAGGPERRTADTPSPSPPPPVGTGNAPARGSGAGSRWSGFKKRKQVLDRVFSSSQPNLCCSSPEPLEPGGAGRAEQGSTLRRRIREHLLPAVKGPAAASGAAGGTPPGGRSPDSAPSSSSASSSLSSSPQPPPRGDRARDEGARRQGPGAHLCHQKSSSLPGTACLEQLLEPPPPPAEPARSPAESRAPETGEEHGSSQKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSLFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MATALMAAATTSCSPRRAAPLLKPMASSSSSPSSARARRPLAQQLPRLLATAAAAVAAAPLPALAEQMEKAALFDFNLTLPAIATEFLLLMVALDKLYFTPLGKFMDERDAKIRGELGDVKDASEEVKQLEEQAAAIMKAARAEIAAALNKMKKETTAELEAKLDEGRRRVEAELVEALANLEAQKEEAVKALDAQIASLSDEIVKKVLPSA
The following text describes a protein:
Function:
May be involved in cell wall organization and biogenesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTHITLGQAIWASVRPIIKIYLIIGVGFGLCKMNILTVQATRSISDIVLTILLPCLSFNKIVANIEDNDIKDVGIICLTSVILFATGLGFAFIVRSVLPVPKRWRGGILAGGMFPNISDLPIAYLQSMDQGFIFTEAEGEKGVANVIIFLAMFLICVFNLGGFRLIENDFHYKGDDDEENTLTNDDSAQQPTQPIEGNSSSSSNQDILKEPNESTVPNSSQASYISEKNKKEKTELSVPKPTHTAPPAIDDRSSNSSAVVSIDSITHSLRTNHVDAQSVSELNDPTYRTRSQPIAYTTESRTSHVHNNRRNSITGSLRSIDMRELPAEGMSDLIREYSNVDQYGRRRKSSISSQGAPSVLQADGTISPNLTRTSTLQRVKTSNLTRIITSDATVSKKDIETSGSSLPKWLQKFPLTKFFVFFLKNCLRPCSMAVILALIIAFIPWVKALFVTTSNTPKIKQAPDNAPALTFIMDFTSYVGAASVPFGLILLGATLGRLKIGKLYPGFWKSAVVLVFLRQCIMPIFGVLWCDRLVKAGWLNWENDKMLLFVTAITWNLPTMTTLIYFTASYTPEDETEPVQMECTSFFLMLQYPLMVVSLPFLVSYFIKVQMKL
The following text describes a protein:
Function:
Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. May play an important role in testicular development and spermatogenesis.
Sequence:
MKEAAQMQGREGAGAWRSVGTQTGSVTGQIPRLSKVNLFTLLSLWMELFPTPGQNQESQKKEAESCGHLEKNEDTAKILADKKQVKKTGLVVVKNMKIVGLHCSSEDLHAGQIAVIKRGSRLKNCDLYFSRKPCSACLKMIVNAGVNRISYWPADPEISLHPEVSNPTSTEDAKLDAKAVERLKSNSRAHVCVLLQPLVYNMVSFAEETSYKCDFIQKIAKAQPDLNSDFYSECKQERIKEFEILFLVSNEEMHKQILMTIGLENLCENPYFSSLRQNMKDFILLLATVASSVPNFKHFGFYCSDAQQLQALHNESLSQEIARHCMVQARLLAYRTEDHKTGVGAVIWAEGKSKNCDGTGAMYFIGCGYNAFPVGSEYADFPHMDDKQKDREIRKFRYIIHAEQNALTFRCQEIKPEERSMIFVTKCPCDECVPLIKGAGIKQIYAGDVDIGRKKADISYMRFGELEGVNKFTWQWNPSEAHIPNQADPESRESKYI