lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in outer membrane lipid homeostasis. Likely transports phospholipids between the inner membrane and the outer membrane. It would provide a bridge-like structure that protects phospholipids as they travel across the periplasm. The phosphate-containing molecules are captured along the length of a hydrophobic groove that is continuous along all but the extreme N-terminus of the protein. It also appears to control, directly or indirectly, levels of cyclic enterobacterial common antigen (cyclic ECA), a soluble cyclic ECA molecule present in the periplasm; TamB, YdbH and YhdP are redundant, but not equivalent, in performing an essential function for growth and maintaining lipid homeostasis in the outer membrane. The transport functions of TamB and YhdP could be differentiated according to the fatty acid saturation state of the phospholipids, with TamB transporting more unsaturated phospholipids and YhdP more saturated phospholipids. Any of these three proteins is sufficient for growth.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=Forms a periplasm spanning bridge. A periplasmic localization is essential for function and stability, while the N-terminal transmembrane region is required for YhdP to be fully functional.
Domain:
Forms long, thin, rod-type structures predicted to consist of stacked beta strands. Contains essential helical regions at the N-and C-termini, which may embed into the inner and outer membranes respectively, reinforcing the envelope spanning nature of YhdP. The inner membrane-interacting regions, particularly the P-helix, are required for YhdP stability. The C-terminal helices, particularly C-helix_1, are required for function, potentially in anchoring the protein to the outer membrane.
Sequence:
MRRLPGILLLTGAALVVIAALLVSGLRIALPHLDAWRPEILNKIESATGMPVEASQLSASWQNFGPTLEAHDIRAELKDGGEFSVKRVTLALDVWQSLLHMRWQFRDLTFWQLRFRTNTPITSGGSDDSLEASHISDLFLRQFDHFDLRDSEVSFLTPSGQRAELAIPQLTWLNDPRRHRAEGLVSLSSLTGQHGVMQVRMDLRDDEGLLSNGRVWLQADDIDLKPWLGKWMQDNIALETAQFSLEGWMTIDKGDVTGGDVWLKQGGASWLGEKQTHTLSVDNLTAHITRENPGWQFSIPDTRITMDGKPWPSGALTLAWIPEQDVGGKDNKRSDELRIRASNLELAGLEGIRPLAAKLSPALGDVWRSTQPSGKINTLALDIPLQAADKTRFQASWSDLAWKQWKLLPGAEHFSGTLSGSVENGLLTASMKQAKMPYETVFRAPLEIADGQATISWLNNNKGFQLDGRNIDVKAKAVHARGGFRYLQPANDEPWLGILAGISTDDGSQAWRYFPENLMGKDLVDYLSGAIQGGEADNATLVYGGNPQLFPYKHNEGQFEVLVPLRNAKFAFQPDWPALTNLDIELDFINDGLWMKTDGVNLGGVRASNLTAVIPDYSKEKLLIDADIKGPGKAVGPYFDETPLKDSLGATLQELQLDGDVNARLHLDIPLNGELVTAKGEVTLRNNSLFIKPLDSTLKNLSGKFSFINSDLQSEPLTASWFNQPLNVDFSTKEGAKAYQVAVNLNGNWQPAKTGVLPEAVNEALSGSVAWDGKVGIDLPYHAGATYNIELNGDLKNVSSHLPSPLAKPAGEPLAVNVKVDGNLNSFELTGQAGADNHFNSRWLLGQKLTLDRAIWAADSKTLPPLPEQSGVELNMPPMNGAEWLALFQKGAAESVGGAASFPQHITLRTPMLSLGNQQWNNLSIVSQPTANGTLVEAQGREINATLAMRNNAPWLANIKYLYYNPSVAKTRGDSTPSSPFPTTERINFRGWPDAQIRCTECWFWGQKFGRIDSDITISGDTLTLTNGLIDTGFSRLTADGEWVNNPGNERTSLKGKLRGQKIDAAAEFFGVTTPIRQSSFNVDYDLHWRKAPWQPDEATLNGIIHTQLGKGEITEINTGHAGQLLRLLSVDALMRKLRFDFRDTFGEGFYFDSIRSTAWIKDGVMHTDDTLVDGLEADIAMKGSVNLVRRDLNMEAVVAPEISATVGVAAAFAVNPIVGAAVFAASKVLGPLWSKVSILRYHISGPLDDPQINEVLRQPRKEKAQ
The following text describes a protein:
Function:
Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMAQENGAAWDKEMPSVYTNLSFSLKGSVHYQRILTPLCGSYDKELKFIKCQYKEEPMIPICPVVSFTYVPSRLGEEAKMATGNYFGFTHGAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAVGTVAVARPAPVAVAAAANAAAYGGYPAAHTATDYGYTHRQQEAPPPPPPVTTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATVPTVAQPQPAVAETYYQTVPIALSLPVAPKAGYSQGAAQYTQAQQTRQVTAIKPANPSPATTTFSLYPVSSSGQPVAAAASVVPSYTQGATYSTTAVTYSGAAYSGYEAAVYSAASSYYQQQQQQQQKQAAAAAAAAATAAWTGTNFTKKAPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQTYKEHLEGQKHKKKEAALKASQNTTSSSSSSAAVRGTQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPNVVSQSVTSAAVSKPSATSSSTSSSSGSSSSASPAVKLLTSSSSLSTSSSSKVSSISSTSIVKKVTTPKITFIGGNKLQSTGNKVDDGKMSEGSKATPSPAAQTQEVKIDPMSEAAQTLAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPELQVEVKPSIRARKIQEEKMRKQMQKEEYWRRREEEDRWRMEMRRYEEDMYWRRMEEEQHHWDDRRRVPEGGYPHGPPGPPGLLGVRPGMPPQPQGPTPLRRPDSSDDRYVMTKHAAIYPTEDELQAVQKIVSLTERALKLVSDSMADQDQTKTKESDDKKEPSKERALKGVLRVGVLAKGLLLRGDRNVSLVLLCAEKPTRALLSRISENLPKQLSVICPEKYEVSCSIPEAAIILSSCVEPKMQVTITMTSPVIREESTSDGDVTPGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSVFPSWALELLVEKAISSSSGPQSPGDALRRVFECVSSGIILKGGPGLLDPCEKNPYDTLATMSDQQREDITSSAQFALRLLAFRQIYKVLGMDPLSQMNQRFNVHNNRKRRRDSDGVDSFEAEGKKDKKDYENF
The following text describes a protein:
Function:
Regulates expression of PIS1.
Sequence:
MLFSSSSSSLNSEVSQVFSENISSRSTTLTESSTQSEIRQHFGNEDFSGELPKKLIQLKKLKNGGTTIKKAKEDLEYCYDSLRLYENPYVTSSVDKKCGYSIELYLDNKYKTLMFSDLQLNADYPLYYDSSLDNISTNVERERATPLQIKGKIRINIDREDQALLITSHSISLKCFTKEYACFVNSETSKNSYSDKIIKELNHTEFFESSTYPKQQLRVIHHSLNDKKILLTKGTYDYPFTFTLQANTFPASFSSFFGKTHFRIESLTTIMRIPSKPKNLLKFLKNESFTDKIILTEEIKVKRVLPSTSMLKFETFQLRSYNTASEIVVSVIGNSKLIEIGMPFQMILSITKTDSSIELQEASLAVAQRMAIPSIDLKTKKILREPYIKKSEYLLRTVESQSFDSDKTIFGFCFDDVVIPTYADGLPSWFKTFYCEPSSFYPNHAALKVTHLLLFRITYSRNELVEGLEMKKNYRITVNFPILVGDSDISTSSLLPKYEKFENISDLQDEPPLYSMVAGENSL
The following text describes a protein:
Function:
Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. Positively regulates macroautophagy in dendritic cells. Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCDRNGGRRLRQWLIEQIDSSMYPGLIWESEEKTLFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVAPAGCMSDVTEMECGRSEIEELIKEPSVDEYMGIAKRSPSPPEACRSQILPDWWAQQPNAGLPLVTGYTAYDAHHSALSQMVINFYYGGKLVGQATTTSLEGCRLSLSQPGLPKLYGPDGLEPVCFPAADTIPSERQRQVTRKLFGHLERGVLLHSNRKGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTNMFLRDLQQFYATQSRLPDSRVVLCFGEEFPDTAPLRSKLILVQVEQLYARQMVEEAGKSCGAGSLMPALEEPQPDQAFRMFPDICTSHQRPFFRENQQITV
The following text describes a protein:
Function:
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLRISGKSVSVGEALRGRVSDRTEEVLRKYFDGNYSGHITLSKDGFGFRTDCALHLDSGITLEADSNAPDAYASADQALVMIEKRLKRYKSRLKDRSARKAHVASAALAAMDATSYVLEAPGEGEDEDEVTGYSPVIIAEATTSLKQLSVSEAVMELDLSGAPCLVFQHGSSGRVNIIYRRADGNVGWVDPPGGKADGKAGG
The following text describes a protein:
Function:
Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids and the shortening of 2-hydroxy long-chain fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MDGVEIIAKSIKNSAIEKVFGIVGVPITPIAYELQAQGVGFFGFRNEQSCSYAASIVGYLTGLPGLCMTVSGPGVVHALAGVLNAQSNGWPMILLSSSIDQSLVGKGGFQECKQFESAELYCKKCYYLTEIDHFPEILKDAIETSLSNRPGPVYIQIPADLIKSKCKESPNIREAAGYGTIAIKSVVPDMKLIKDAVQLLSEAKRPLVIGGKGAAYCRSENELLEFIEATKIPFLPSPMGKGLLRDDHPLVVGAARSYALKNADVVLVLGARLNWMFNFGKAPTFSTDVKFIIVDVDENQASKTKNPNVVPEIAIVGDARLSIAEMRKLFIGETDEQPQPPQDSLIKSMKMEESWWSNLNQDIQVKTKSLATLMSEPQNNDQEYLTYHKVFNALRVGGLFQEDTIFVNEGANTMDIGRLCIPQTLPRSRLDAGTLATMGVGVGYSVAAQICFPDRSVVCIQGDSAFGFSAMEMEVAVRYKLPIVFIVLNNNGVYEGLESMSDPKYTSSTESASLHIPPTSLSVDTKYELIMQSFGGTGYSISTISNLLDICKQIKSKQISLPTLLNIKIKPTGTKPKIVH
The following text describes a protein:
Function:
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium.
Sequence:
MDPETCPCPTGGSCTCSGECKCEGCKCTSCKKSCCSCCPAECEKCAKDCVCKGGEGAEAEAEKCSCCQ
The following text describes a protein:
Function:
Pore-forming protein that promotes parasite exit from host cells: mediates formation of a pore in the parasitophorous vacuolar membrane, leading to membrane permeabilization, thereby facilitating parasite egress from host cells. May also form a pore in the host plasma membrane. Preferentially binds inner leaflet lipids, such as phosphatidylethanolamine (PE) or phosphatidylserine (PS).
Subcellular Localization:
Parasitophorous vacuole membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, microneme membrane; Multi-pass membrane protein.
Domain:
The MACPF domain includes the central machinery of pore formation: acidification causes a significant structural rearrangement, leading to oligomerization and deployment of transmembrane beta-strands that enter the membrane as amphipathic beta-hairpins.
Sequence:
MFVVDLSLSGNMRSLTHGKSIHRSSIVVVTHCSHRLSLSPLNRPALFPSHSDRYTVPWRCRPSSWRLWITFVCLLTLHMFGLSSAVKRDGEVPTANLRASLSPDSSKEDAMLLSAIGGIGPTESRLQHIPFRTTRYLPIRSHVLQSTVERIESPEALNEVPTKVERNEFTEKGDKTEQVLTAQADHKSLLEGRSESTSTAPDDDFDFLFEDDTPKKPKSRVNKGTSSDETSPGDRSSGEGSSASDSLLSVVHRTKGNATQANKNQKRITHPKSKAQHQKKVTKKQGIPGSDSLGTSSADFDFDIDSSSNTQADDSQRQSLGDSSALDLFGSDTGDTGDIFGFSNSSSDGGNAAANDGGLFSSSGMGPTGASDETSANPLGSILGGVLNPFAQQQSITPMTDKADEWSKENMKAFEEKMPKKMRDDGSPDSWYKQAVPQESVADLNRMRENRRIAEENRAAAPLSAVYTKATKTVPAINYLGAGYDHVRGNPVGDPSSMGDPGIRPPVLRFTYAQNEDGVSNDLTVLQPLGGYVRQYVACRQSETISELSNLSDYQNELSVDASLQGGDPIGLNSFSASTGYRDFAKEVSKKDTRTYMLKNYCMRYEAGVAQSNHLKWNVTLAFAAGVSQLPDVFDAHNPECACSAEQWRQDQNAEACTKTNVPIWISFIEQFGTHFLVRLFAGGKMTYQVTAKRSEVEKMRNMGIDVKTQLKMQLGGVSGGAGQGTSSKKNQSSSEYQMNVQKETLVIGGRPPGNVSDPAALAAWADTVEELPMPVKFEVQPLYHLLPVEKQEAFKQAVTFYSKAVGLTPQDLSALTGVTRNLPKQLTQATQVAWSGPPPGFAKCPAGQVVILGFAMHLNFKEPGTDNFRIISCPPGREKCDGVGTASSETDEGRIYILCGEEPINEIQQVVAESPAHAGASVLEASCPDETVVVGGFGISVRGGSDGLDSFSIESCTTGQTICTKAPTRGSEKNFLWMMCVDKQYPGLRELVNVAELGSHGNANKRAVNSDGNVDVKCPANSSIVLGYVMEAHTNMQFVRDKFLQCPENASECKMTGKGVDHGMLWLFDRHALFGWIICKTVNEPAMHVATDVGKAKGNGKKKKGKKGKNKTNAPNEVEEGQQLGADSPSQVSVPADADSGPTSKTMSSLKLAPVKLLDL
The following text describes a protein:
Function:
Peptidyl-alpha-hydroxylglycine alpha-amidating lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Confined to cell bodies.
Sequence:
MKSTDSAKCLGSKSLAICCLLLHLLLCIRPAVSQTQSPQRYLHNVDSNSNNNERLHQILKGSGAGSGATQLNWPQPPKQTVPNVKTELAKLNNTYVYQNAWPANNVKLGAVTAVSFDKAGNVVIFHRVNRVWGQTTFDNRNQYQEKYRGPIRESTILALEPATGKVQYDWGKNFFYMPHGLTVDPEDNVWLTDVAMHQVFKFPPRGGDGKPALTLGDAFQPGSGRKFCKPTSVAVLDNGDFFVADGYCNARILKYSRKGELILFWGQNTFSGISYDVAPQNFFAIPHALTLVPELQLLCAADRENGRVQCFLSSNGTFHSQYHNQLIGDRLFSMAYTPAAGGQLVIVNGPTAELGIHPEHYNEVHGFVLSMRSKQLVSKFGPNNLQFQNPHDVAVTADGNEIYVAELNPMRIHKFVHRSLAKPMSLSASKDSRDSAISQAVGGDQVPAVAVHHPSGKAILVASLMLLFAGSTFALALIFARRRKRGCLPFGARGRRHAWEKSDGFKLGGLLDRDRNGFEKLDQQASDEEQETKTLASAQYA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAQKSADGGDKVQEVFIKNLFMRCKEERSETPWQMPEMVGYYTEDPLAIAPVPTVDEARLSVKKVVCSPDLPMPEFPSGAAPHPDQTINIQCQICNKMFATKSAFQAHQRTHTRETEDPYRCNICSKTFAVPARLTRHYRTHTGEKPFRCEFCNKRFSVKENLSVHRRIHTKERPYKCDVCSRAFEHSGKLHRHMRIHTGERPHKCDVCSKTFIQSGQLVIHKRTHTGEKPYVCTVCSKGFTCSKQLKVHSRTHTGEKPYSCEICGKSFGYNHVLKLHQVAHYGEKVYKCTICNDTFTSKKSMEAHIKSHSENAPTPPASSTSNESSCSSSTSDKENKDSLPMPQDPLSYDSDIRYLIYPRDSGYMVPQTGVELLAAAATATEREDVVFNIITKNPVMIRQPYFQTPSVQYTPLNAGDAIRKKVEAVLGVGEMPSSEEENILTPPSSNPVSPAASPVSMSSPDRELSLPPRKRSRMILKSLEETIDLSPVRYSSVIQYAGAS
The following text describes a protein:
Function:
May regulate angiogenesis through KDR/VEGFR2 and NOTCH1 pathways.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGLGEASARGTSMEGDCLSCIKYLMFVFNFLIFLGGSFLLGVGVWVVVDPTGFREIVAANPLLFTGVYIILAMGGMLFLLGFLGCCGAIRENKCLLLFFFMLILIIFLAELAAAILAFIFREHLTREYFTKELKKHYQGYNNTDVFTSTWNAIMNTFDCCGVNSPEDFEESIFRIINPSEMVPEACCRRNNHVGESGFSNREECLSGSMLYRNNKGCYSAVVDYFEMYIYVAGALAIVVLTIELFAMVFAMCLFRGIQ
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAAASIGDAADAGVAATAAAAVDTALAGTSLSFDHKLTQLRSSLQSLQQLLPPRASTTANLLESFVAVSGDGLAQRLHEQHQQGQQVQQDRQAQPGASATAATITSSVRPSAQPEPASSTGLARGSTGPYAQTAASSSGGGACSNAGAGEPGQLGVDIAFMELAAGYSRRTLQPPSSESSGASVGGAPGVDTACACALLHQPPEPPPQPAEPAPAHSLYLQQASLADPQSSSSSPQASSEPDYRADANETWHDAYHLGHSSYDGHGAVLGHTDSELELEGPADPELYGLHQEPRRTSGDAEDSAAEEHGAPASASTGDAVELQRAEAAAGMGSITRSMVSPARRRVWQLVGQGGSALGGSNGRMPEPAQPLDMPDAEHSQWPPRPASVRPAGSPGPHGLRLLHSANLQNCSHGGGSSGASTGGGGTGPDATRESSAVWESEATGAEDKEAGEDHGSTSCEEPGLASQTEWCGFGGFGKQSPSLLRQNTLTPVFGFGPLPTGDESPAPGGFGQPDLQSEARLQPASTGISPHLMEGGAEWQHQHQQLLPSSEQRGSLAPSNAVGASAAGEAVRQRRRWGSPLQGSAVSGSWQHIHAASVAAGVVGGATSSLHRSSPNGAGANAGMFSPTVATARASQGGSPSRHVFSTAAPAAMLAMAGADGEVLLEPDAPAGAHPAAGGFAATYQPYGEEPANEPSLVSAAAEYEGLLQEQGFMPEYDGQQHELQDGHALLAAATEPEPEHHSAGWAADGDVSNGGGSSAYSSSGGVSGDGRPIDPRLQHRHAWQDTGVSTTSAARGPRSLRLVPPTPHTGVAVGQPYALAAVPGELLPNHNDEVLCGSPTSDMAATAGAAQVSEPGARGSGSNNSSSGPVPSYTANRGGVAFIVGAEGAGGRSPLRSATPRASPMRAARAAPHATSQPTQPSVNTADAPAGPLDWDLLNRQLREAGFGGLAMVSAAATAAAIANAAAEAASAPGGGVLMAPEPGSLHRCLGSVLEQYVRRNKLVTELLAATEQSGRVAAQQEAALRDLQRELNVAKAAADRARRELAELASQQLPKTEARYSAQMAKLRSEAAKMKESLRDAEVEAAAKGEEIRSLRATITGLQAAAGHTADVEAAGLRQRLAQLEAVVRARDKELDKLRSIKEVTVVQAEDGQANALDRAYEAETTARRLEAELVAARTRVGQLEQANAKRDRDVATMRDDLAAIKTCEAAASRAAAERAAAAEEAARRSEAEAAGLRGKVKELEAQLRAARQELDKRRADSEALRSAAYQEVYRLEDEVRVMGADLAAARNRAAQLEHVVRSKERDVARTKDEKEAAKAAERERARVAEDVSIKLEAELQAVKVRLAQAEGGLRTSEREAARLAELLRQTQGAEVEAWLKQAKSEEGSKKLESDFMSLRLRVLQLEAALKGRDKEVDKLGRGVEAIKAEAHELASKLAKSEEAARKAEGELSAARGKVLTLEGHVRVKEREQERLVRLVEGLKAGEAEVASRQGALEEAARRLEAALMAARGRVSGLEGVVRARDAAVERLNRQLEAAKTSDFERTAQVSKMEEVARQQEAESAAVRQRVVQLEGLLRTKERDLERSNRQAEAARAAEGDMERRLADAGVAAAKLEVEVAAGRTRAAQLGEELRARERELAALTRSLEAQRSAEHSANVAVGKTEEAAKRLDSEASELRQRLVQAEGLLRVREREAERVARVLEAAQAAAADAAFKQSEAEAASRRLEAEAAGLRQRLAQTEGAVRSRERDVDRAEKLVEQAKCAEAEADTRRRAAEASVSAVDGEMSSLRSRIGQLEAAARGHTKEVERLMRVVDQSKTAEIAATARAQRSETAAKQVAAELVSARGRLSKLEASLAARGAESVRLQKLLVAAEAAASAQEARAEEFMRRVESDMAAMRQRALQLAGLLKGRDRQLTTLRGGSEAAQAEQEKVHDRLRQCEDVIRKLEAELVSERQQVAQTAGQLRGRDKQITTLRNGLEALQGDQEKATAQLRKCEEALRKLDSDLSAERQRAAQLDGQVKARDKELERLTRQLDAGRDHSSSAAVVAGKEAAGLKEAAAKAEAALATARARITELESEMVSKERQLDGLQRLAGYSRAGDAEAAALAAERAGRAEEAAKRLDVELAGVRQKYSQLEHMYRSREAVIDKLKASLADKVAREERRLARDKAAYTRIRAAYLQTMAHSSTAGGAGGTPSGKAAGAMAAAARELRPVEIVGLYESRREALEEELSVCRAEVRSLAEQLRDAQNLITMKERSGAWRTPQELTDMQARVIMLERRCADLQREVERGRAEAAEAGRAAERRLAEAERRAAALKEDNEALVHELDGRPTLQENRALKRELEILEKRVLQMKGSAAASGAGAVAEGGETALGLAVASKGRAGGPLMTTAQRMARDKSLHRLGLRGLEDWPKDVLVDLVQDVCIELDLSDATTLPAAVRKTLRVVDAAPRMEGFIAAVCEAVYKRGAAFVPPHIDGTTDPNRVLEVLAVWLGLLQEGSQLRGVMRSVSEALASRAEGMATPIHGPGDVLLSIRQLVEAEAVALTARESLAAASHHMAQQPEALLSRLVHHFMRLFDCPSLEGVVPCVNRLYVSLNELRNFARSLAATLGLPADAGASACMGRVRELLDAAAGRGEGGAGQQQRSSADGGGDRLLPDYIKGNHASAASPAASAGQPPAGAAAAAVGVEVSAALERLMAVFTVRTAGAAADAAERAVGRLRRLDEVLPRYQRLTSQLFEALRCTSLEEVMPAVRSLLAAAQQALY
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MTVKTRFAPSPTGYLHVGGARTALYSWLYAKSQGGEFVLRIEDTDLERSTQAAVDAIIEGMTWLGLEWDEGPYYQTKRFDRYNQVIDQLLAEGKAYKCYAPKELLDEIRAEQEANKEMPRYDANHPKIKAVNDAAKEGEPCCIRFRNPKEGSVVFDDQIRGRIEIRNDQLDDLIIRRTDGTPTYNFCVVVDDVDMGISHVIRGEDHINNTPRQINIYKAMGATIPTFAHCAMILGDDGAKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWGHGDQEIFSRDEMINLFSLNAISKSASAFNTDKLLWLNNHYIKTSEPEYVAKHLEWHFENQGINKATGPALAEVVKLVGERCNTLVELAQQSRYFYEDFAEFDADAAKKHLRGVAKEPLMLALSKIEALTEWNTEALHHVIAQVCEELEIGMGKIGMPLRVAVTGGGQSPSVDAVMNLIGQERVIARIKMALEYIETREANA
The following text describes a protein:
Function:
Inhibits the kinase activity of the cyclin-CDKs PHO80-PHO85 and PCL7-PHO85 under low-phosphate conditions.
Miscellaneous:
MISCELLANEOUS: Present with 2930 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes predominantly to the nucleus in both high- and low-phosphate conditions.
Sequence:
MKFGKYLEARQLELAEYNSHFIDYKALKKLIKQLAIPTLKASSDLDLHLTLDDIDEKIIHQRLQENKAAFFFKLERELEKVNGYYLARESDLRIKFNILHSKYKDYKINGKLNSNQATSFKNLYAAFKKFQKDLRNLEQYVELNKTGFSKALKKWDKRSQSHDKDFYLATVVSIQPIFTRDGPLKLNDETLHILLELNDIDNNNRRADIQSSTFTNDDDDDNNTSNNNKHNNNNNNNNNNNNNNNNNNILHNNYELTTSKISENQLEHLFQASSSSLDMEMEIENWYKEILNIATVKDVQRKHALLRNFRETKIFTYLLQNSSESFHKNVFSLLKECLTTLFLLLVASPLDDNSLHIFYKSNQDHIDLSYCDEDDQVFSRKNVFHEAASCPEKSRLFILDEALTTSKLSKETVQKLLNAQDIHSRVPLHYAAELGKLEFVHSLLITNLLEDVDPIDSDSKTPLVLAITNNHIDVVRDLLTIGGANASPIEKPILDYSKNVISSTKVQFDPLNVACKFNNHDAAKLLLEIRSKQNADNAKNKSSQHLCQPLFKKNSTGLCTLHIVAKIGGDPQLIQLLIRYGADPNEIDGFNKWTPIFYAVRSGHSEVITELLKHNARLDIEDDNGHSPLFYALWESHVDVLNALLQRPLNLPSAPLNEINSQSSTQRLNTIDLTPNDDKFDLDIQDSIPDFALPPPIIPLRKYGHNFLEKKIFIKLKLRPGLESIKLTQDNGIIMSSSPGRITLSSNLPEIIPRNVILPVRSGEINNFCKDISETNDEEDDDEISEDHDDGEIIFQVDSIDDFSMDFEIFPSFGTRIIAKTTAMPFLFKKVAINSIATMNLPLFDTRLNNIGSLTLDYQIIFPYPGNPLKIINYEPYWKSTGSDLMTSSKDGNFVTSSSLNGSFISVLVCALNDETIVAAPKPYVEFKGTKILLNDLTKEQLEKVVDYDFGKIDGSFDEVTLKQYLSSRVVPLRSLLEVIPGSAQLVIRVYFPTDKEIDTIPIKISPFININQFIDKLLLIIFEHERFLRHSGSGSMRQIVFSSCNWEACSILNWKQPNFPVLLQMKNLLRDSTTGKFVGDTPNCLKELAVNPQKMSYLNTELINIHTMVQFAMNNNLLGVTLPYEVLKICPSLARIIKQNGLLLIASVGENDQIPADGGYSGIYYACELLFENNIDM
The following text describes a protein:
Function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Sequence:
MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGESRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
The following text describes a protein:
Function:
Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.
Sequence:
MDIAQRKIDFHRLVRDAPMITHICFDACSKTVKIVYSSSVPLSHTTLECTRILSKQSEDRIYCIQVQYPDFPLILNFFGENCPLLKGTTVDFVVTASQNAEIEEVIRKVLDVELRHVDAFNGLVNGTSFLLRNIEAECFTYSFDESQEYEFQTLNNDSMFPYLLINIRTGVSVVLVEGENQFKRLGGSSIGGGSFLGLTELITGVSDIEEMMDRALQGSPDEFDIFIRDIYGDRASNFNMDPHLLAASFGRVTRGETVRRAENFDEQSKNNAILSLLRMILYNVSQLAYMLSEISNVKRVFFNGFLVRNRPIVMKTLSFACNYWSSGKLRAYFLRHENYTTGLGAFLENFPNADLYWKEYCSGSTALGRFVPVEPLETGFKTQTFALRCTGFKAAPFALLVDQDGKPDTIDFNKDEEARNFWIEILDKTINDITKFAIASQENCSNKEDLTNRAEDFQSDFVKTMDIIKEHHVAYGNSNARNMLEVREQILQEKGFDDIYVQKKHAENCTAIAELPRVLAKIDELKNTGDEKTVLEYVSRGLLAGNVFDWGAKEVVKMMNSESGLTFQTAIDHVENRPWLFDGFDSFYKKHKEYKSVLIFVDNSGFDYILGIIPFARELLRNGSRVIICANTSPALNDLTYREMVELAPELKNADSDLAKFIDSNQMMFVQTGQESPCMDARRVHQDLNETVKKFNTDLVVIEGMGRALHTNFNVQFKCDSLKAAVIKTQWLADRLGGKMFSVVFKHEHGVSVTN
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Subcellular Localization:
Mitochondrion.
Sequence:
MSTSLRHTALHAFHVGRRARMAPFSGYDMPINYAAGAVREHLHTREAASIFDVSHFGVVEVFGADREKFLEWLTPSAPSRMPSGKAALTMFLNDRAGVKDDCIVTRYDDRLVVVVNAGCKDKMIAYMRQSVADFTGDVALEMEDRAIVTVQGPKAASALAPHVEGLDKLLFMQGRQDVDIRGMRIKTLTRCSYSGEDGFDIVMREEDALPIVELLLQNPDVQAAGLAARDTLRTEAGLNLYSHELSEDIDPVAARCMWCVPKHRMTEGGFVGHERLAQLVKKAKELVPRVRVGILAAPERGPIPRNGTPVLVEGKCVGVVTSGVPSPTLGRNIALGYVDRSYSNIGQQVGLDVRGKLVKAEIVNSRFVAPRYYRG
The following text describes a protein:
Function:
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MKDNESEEKEDRNVFKLLSQLRKEKLFITNERLNIQKLNKSIKKKTDGLIEATWVTTKQRLYLLSQREFTTQNYEHIKSITNSEFVEAKTLLGFQTVKINNLLQNLRKQPQELARWLFVGEQINDDQFSNVLQTVVTGLYSSCIFPEDTTYMLKLLLELAKLQLFKSENPRRMLKQGTCSFKNLFFIFTEVLPTAKFFLSAALELPILRLAACRDFYLDIDPDKTLMRYRHNENNLKSEFRDIQEYRTEVIRKLSEFTNSFISSLRENVYSFPKPIAWIVYHISKIITKSFGSKEAYAIVTELIFTLYICPAIVDPEQYCISDAQITEVTQHNLMQVGQILQVLALNKFESPENRFSDIYNLLDNDVVCNFMEDILFNLEFDDDAPPVDLAPSIIRDSALLAEDELNNFILFLQKVHNEMMQNDNFKKHLGDNSIEEQIASLILPSSLESSPKTSKPYTNGFSENTLKRNHFLSLVTKNHTSKSRDEISQNIPLTVLIFSMEKDLVEPVGLLPEEKILNMNLTAKKEVILPKPSEIITEAVNGRVEEKPFSNFPDEGSIGNTSDNLEAISEAASNHSVASSLELENDQNDNLSDMISANVSGRGTPNISGRDTPSSQVNDNEERPLPEARQVEQPQPQISRQIRSEIDDKFCKFEIKKLLEGDETISIISETWSTDVLASDNETIDAGDSRAERQGLQLVDQAINEVPTGNILDISETQSESAWSTDVMASDTERLTEVDNDDAGSVAQSDETRSETDENPTRRLSNSSNYVNYLNYQEYRKVEIKNNVKTDNNANNVLFKSVTLTDTQHNLSFSELKIARKKDAPGPSGFNPTELLKQNTYDERPNEILLSNCSLNSSSSGSSSNSFENKHSHTETCWESKQWLNSSGSSLNVTSTPSESTSELSVLSVSNLNPNILVKKAATLNRSLKPSASTGAIPKSISFDMSADKGDKYLDDDQRSKRGGFFGKLRMGFRNRRGKSFRNQDDFRLDVEEFGAGKKTPNDSPVKISSSEVSEDILAKYRAKPFIESSPKEANGNDKIPPKVRSDDSTDNVDVNNSFDDIKRKLRLVLSNTTSQTPKVIKENRLSVKSKVETILRLELGKARKLKEWSNIARISETLRFINLLNESTCLSLLQSLREDFLQRSVYTDYLIYSRQELLFCQSYLDGLSEQVNNDKQQCEKYLSMICVRKFLLDEESRITQFCEEFKEINLFDEKCDFLNNFYEQVYSVMQRSGLWQDIFKNQGDAIKITLERCIMSKIYKYALYPNGDGDRDRDHVLFQHIEKLASIISPDHKALMIHKMFLREMPWIPAQDALKAMNAYKTPRDKVKCVVHCAKCIMDLLAFSQNSGSMTADDFTPVLVYVIIRVNPPDLLSTIQFVNSFYHSQIDGEELYWWTQFCSAVEYIKTMDYSD
The following text describes a protein:
Function:
Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Sequence:
MEPFTHNDGNRDELIIQQKRDIEKEISDTTPLVSEQLPLTCLYAEYSGDEIFTAKIQDLSKKYKFIRRTRPDGNCFFRAFAYSYLEYLISNTSAYQEFKKLAEESKEKLVQLGFPSFTLEDFHETFMEVIQRVSPDNAGGHSTVQDELHKIFNEQGYSDYVVVYLRLITSGKLQEEADFYQNFIEGDLTIEAFRHLEVEPMYKESDHIHIIALCTALGAGVRVEYLDRGEGGTVKAHDFPEGSEPRIYLIYRPGHYDILYPN
The following text describes a protein:
Function:
Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi.
Subcellular Localization:
Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Sequence:
MAAGIREKQTVALKRMLNFNVPPVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRMCQDLRNQLYESYYLNFISAISRSKLEDIANAAIGANAVAQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETIMDTIVDSLFCFFVTLGAIPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESTGTEGTPAGARPKKKNKKSYDLTASDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGIEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKTRKLDVYFEYEEKIMSKSTLDKSLLDMISDPDAGTPEDKMRLFLIYYISSSQAPSEIDLDQYKKALTDAGCNLAPLSYIKQWKAFTKMASAPTSYGNSTPKPLGLFSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGSDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLIDYIKGKQGKHVLYGCSELFNATQFIKQLSQLGQN
The following text describes a protein:
Function:
Cleaves, in an endo-type manner, the gamma-glutamyl bond between D-glutamate and L-glutamate of poly-gamma-glutamate (PGA).
Subcellular Localization:
Secreted. Secreted, cell wall. Note=Cell wall localization shown in PubMed:11987133.
Sequence:
MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAKNLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGDILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAADPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQWAVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYWKSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKAAGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVTITNMNTSTYWKDKYAGSIRVQ