lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Sequence:
MSTPAASCLSCFYCSFMEAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHQRCIYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHISKKHRTWFFSASSEDERKSWMAMLRREIGHFHEKKELPLDTSDSSSDTDSFYGAVERPIDISLSSYPTDNEDYEHEDEEDSYLEPDSPGPMKLEDALTYPPAYPPPPVPVPRKPTFSDLPRAHSFTSKSPSPLLPPPPPKRGLMDTGPAPEDAKKDPLGLRRVEPSLRVPATPRRMSDPPVSNVPTVPNLRKHPCFRDSANPGPEPWTPGHGTSSVSSSTTMAITTSRNCDKLKSFHLSSRGPPASEPPPVPANKPKFLKIVEEASPREAAKSAPVPPVAPRPPVQKMSMPEVTVRPAVLPRPEKTPLPHLQRSPPDGQSFRGFSFEKARQPSQADTGEEDSDEDYEKVPLPNSVFVNTTESCEVERLFKATNPLGEPQDGLYCIRNSSTKSGKVLVVWDESSNKVRNYRIFEKDSKFYLEGEVLFASVGSMVEHYHTHVLPSHQSLLLRHPYGYAGPR
The following text describes a protein:
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=Peripheral membrane protein of pre-autophagosomal structure (PAS) and vacuole.
Domain:
The first protein part may form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
Sequence:
MATVSSSSWPNPNPNPDSTSASDSDSTFPSHRDRVDEPDSLDSFSSMSLNSDEPNQTSNQSPLSPPTPNLPVMPPPSVLHLSFNQDHACFAVGTDRGFRILNCDPFREIFRRDFDRGGGVAVVEMLFRCNILALVGGGPDPQYPPNKVMIWDDHQGRCIGELSFRSDVRSVRLRRDRIIVVLEQKIFVYNFSDLKLMHQIETIANPKGLCAVSQGVGSMVLVCPGLQKGQVRIEHYASKRTKFVMAHDSRIACFALTQDGHLLATASSKGTLVRIFNTVDGTLRQEVRRGADRAEIYSLAFSSNAQWLAVSSDKGTVHVFGLKVNSGSQVKDSSRIAPDATPSSPSSSLSLFKGVLPRYFSSEWSVAQFRLVEGTQYIAAFGHQKNTVVILGMDGSFYRCQFDPVNGGEMSQLEYHNCLKPPSVF
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKKRRKVTANFDEKIHLGYHKDSSDGNSAADSDQVTFSHSIEGSAPEDLQCYQQLPPSPDQRKLLSSLQYNKNLLKYLNDDRQKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSEFFVYKNEIPLVLEAAKFLDIIDAVKLLNNENNSNFPSEITEKASPAETLSELAGRLSNSHQCKFCSRNFCYKKSLENHLTKTHRSLLIGKKHGLKMLERGFSARRSTRNRKCPVKFDEDSDNDNESDEIDNLDKDNLDKVTFDTEKSDKNDSEDAGSEYNADAEAQEEEISDDYSEGEEQSDKEHNNTEEDPEIADSAGNIHEGLTPVVIQNSNKKILQCPKCDKTFDRIGKYESHTRVHTGEKPFECDICHQRYSTKSNLTVHRKKHSNETEFHKKEHKCPYCNKLHASKKTLAKHVKRFHPENAQEFISIKKTKSESWKCDICKKSFTRRPHLEEHMILHSQDKPFKCTYCEEHFKSRFARLKHQEKFHLGPFPCDICGRQFNDTGNLKRHIECTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCSICGQSFRHGSSYRLHLRVHHDDKRYECDECGKTFIRHDHLTKHKKIHSGEKAHQCEECGKCFGRRDHLTVHYKSVHLGEKVWQKYKATFHQCDVCKKIFKGKSSLEMHFRTHSGEKPYKCQICNQSFRIKKTLTKHMVIHSDARPFNCQHCNATFKRKDKLKYHIDHVHGIKSPDEPLTSSEEKLVSLPMEYPPDGKGYQTETKQYMDQPKYQSESKTMLPNVPNEVCVPVTLVPVQMPDTQNDLVRHTTALPPPSQGILSTQPQPTDYPRTTDLAFLEKYTLTPQPTNIVHPVRPEQMLDPRDQSYLGTLLGLDNTTAVQNIANNERHS
The following text describes a protein:
Function:
Phosphatase that converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.
Subcellular Localization:
Mitochondrion.
Sequence:
MYILDTGARFSAVRFSPVFNPPPTSLRRRYFIVRANLPFPKHQAKYHKELEVAIDAVDRACRLCVDVKRSLFSSKEKIVEKNDQTPVTIADFGVQALVSLELSKLFPSIPLVAEEDSHFVRANNLVSSVVSEVKSKASIGDNHLSDADVLEAIDRGGKDAYTFCNKPATYWVLDPIDGTRGFLKGDEALYVVGLALVVDNEIVLGVMGCPNWPGDSSDGSTGTLMLSHIGCGTWTKKLQNVSGNVAGDWIRCFVDACVLMNKARFCIQESQTWESLPLSGFFDASTVSEDLKHKEILLLPTCCGSLCKYLMVASGRASVFLLRAKTQRTIKSWDHAVGIICVHEAGGKVTDWEGDEINLEEDQSERRLIFPAGGVVVSNGSLHNQILEMISSASPTL
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MSFERPQDPSSALEQATQDVSNLKSESRFLLEEIRASDLEFYESKKRFLNKDTQIHKFIKQHGSLVDNPKEAEFQERIKEDLERCHQLQVDKCTVANSLLYMVTKHLKKVQANIEALEEDGLLAPLEDDAVELANELSRESSVLSSGTSLERRKRTVAAGTLSAGSSLRKRVKKERGRSTQRDGMLSEPPSDEASSHGANFADDLQDFNDELFSLNQQEEDDKQLYCFCQSVSYGEMVACDGPNCKYEWFHYGCVNLDEPPKGQWYCPECRQEMANLKLKKKKRV
The following text describes a protein:
Function:
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching (By similarity). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm. Cell projection, axon. Note=Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity).
Domain:
Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9; A serine-rich region promotes activation of the serum response element (SRE); The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK1.
Sequence:
MKYLVSVGAGPARRAGGLEDVSWGPRVSRRPQSYRAARHVNESLPRSAFRVPAAHGASVTPSAALGSGLPETQPEAVCRGTEKPRFAEGCKPAASRDKNVLAKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAAPGPGPPATPPQPQPSLPQGVHTPVPPASQYSPMLPTAYQPQPDNVYLVPTPSKTQQGLYQAPGPNPQFQSPPAKQTSTFSKQTPHHSFPSPATDLYQVPPGPGSPAQDIYQVPPSAGTGHDIYQVPPSLDTRSWEGTKPPAKVVVPTRVGQGYVYEASQAEQDEYDTPRHLLAPGSQDIYDVPPVRGLLPNQYGQEVYDTPPMAVKGPNGRDPLLDVYDVPPSVEKGLPPSNHHSVYDVPPSVSKDVPDGPLLREETYDVPPAFAKPKPFDPTRHPLILAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGSVIDDGVYAVPPPAEREAPTDGKRLSASSTGSTRSSQSASSLEVVVPGREPLELEVAVETLARLQQGVSTTVAHLLDLVGSASGPGGWRSTSEPQEPPVQDLKAAVAAVHGAVHELLEFARSAVSSATHTSDRTLHAKLSRQLQKMEDVYQTLVVHGQVLDSGRGGPGFTLDDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKAPGPGPEGSSSLHLNPTDKASSIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGNIVRQGKGQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLVPGRTGGLGPSDRQLLLFYLEQCEANLTTLTDAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSKVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVDRVKELGHSTQQFRRVLGQLAAA
The following text describes a protein:
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Subcellular Localization:
Nucleus.
Sequence:
MGNITVDVGLHTRINMPLMSSDLPPLKADGDSKVEKSKAKDEPQRRSARLSAKPAPPKPEPKPKKAAVPPKKAEKAPKGKKGKADSGKDSSNAAENGDAKSDQAQKAEATGDTK
The following text describes a protein:
Function:
Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSARKLQVEIEKTFKKVTDGIAIFDEVYEKLSASNSVSQKEKLEGDLKTQIKKLQRLRDQIKTWASSNDIKDKKALLENRRLIEAKMEEFKAVEREMKIKAFSKEGLSIASKLDPKEKEKQDTIQWISNAVEELERQAELIEAEAESLKATFKRGKKDLSKLSHLSELESRIERHKWHQDKLELIMRRLENSQISPEAVNDIQEDIMYYVECSQSEDFAEDENLYDELNLDEASASYDAERSGRSSSSSHSPSPSASSSSSSENLLQDKAEAEEKVSADASVQDIAEKESLDADKELATNDQEDDEEENQAETQKDGAISNNENMQSEVQTTNPSASTSAVTNITKPTLIQNPSTPLSVSNSKVASPETPNATHTAPKVEMRYASAAAAAAAALAKESPSHHYIMQQVRPETPNSPRLNSTVIQSKWDSLGHTASPKMQTQPVRSVSQSSATTETNVKPTKEENADVPVSSPDYLKDLVNALNTSKEQHKGAIDKEKLTEALNISCVYVPDATDAAKPQYYIPKDPYPVPHYYPQQPLPLFDSSEMTELVDPDTLFYMFYYRPGTYQQYIAGQELKKQSWRFHKKYTTWFQRHEEPKMITDEFESGSYRYFDFEGDWVQRKKADFRFTYQYLEDDDDWTR
The following text describes a protein:
Function:
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Sequence:
MSRAKLDSIRAAGPAILPSLLQCDFGDLRTEIEKLTVAGTRVLHLDVMDGHFVPNLTYGMPIVEGLRRHTDMPLDVHLMISDPIAYAQPMVDAGADLLTFHVEAVDDCVEVAGKIRDMGVGVGVAINPDTDFAKLDCCLDSVDMVLVMSVNAGFGGQQFNPVALDRLRSLKERKPDLLLEIDGGIKAETIGDARAAGCDLFVVGSAIFGQHDYETAINELTQAMHGSPPATGDQS
The following text describes a protein:
Function:
Involved in autophagic vesicle formation.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MDNQPLEEMSLEDIRKQINEQSFLGKFIIQDVEDIIPFVCIVYNNKYPGFYFESIYNHFIRYSNKARSSLWLSFNDQPIQWHIPFFVQIDRINEEVEMVVHFKKRPENVLPISENIQVDIKNRYFWNLKQACMIRYGHKWERQIFQTITIEQQYKMFQNYSDHNYRPQFYEFFDKIWDLTMLKKEQQLSIPIRIFIDGNMIQRSHVLKDAKETLQNVLQPIFEDSLNYNELNVNVLGLQVNLDFPVRLLVSTFINPDGFCYIIIK
The following text describes a protein:
Function:
May activate NF-kappa-B signaling pathways.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASKIGSRRWMLQLIMQLGSVLLTRCPFWGCFSQLMLYAERAEARRKPDIPVPYLYFDMGAAVLCASFMSFGVKRRWFALGAALQLAISTYAAYIGGYVHYGDWLKVRMYSRTVAIIGGFLVLASGAGELYRRKPRSRSLQSTGQVFLGIYLICVAYSLQHSKEDRLAYLNHLPGGELMIQLFFVLYGILALAFLSGYYVTLAAQILAVLLPPVMLLIDGNVAYWHNTRRVEFWNQMKLLGESVGIFGTAVILATDG
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
QTVLLEGGVFRGLAPAVSLSAESGRNEKERPPNPKKQSPPKNVVAAQEGGTPLATPAAPELSQQLSSPTSPPAAARPGGTLAPPNPGDSTLFTDRGRPRFPSRKTLVEFPRKVLSPFSQQGSDSAATQASRGRAGDATSSSSSSSSSDSESDDEEEGDGSEAVRPVKSTSPGGSPKAEAPRSLAGGAPQTGVPAEARPGPQQPHPDLAAAERPRQAKGKGGSGAPEDRRAPKAAAPGSRGGPGAARQSETPSQKIPRSEEADAESQKPPEVKTSLPDPTKSGLSTAPRGGPASAEPAATPAGARLPATPLETGERPLGERVPEPGGQVASPLFSRAPLGGQAAEGVAEAKGELLEGRPLVQGPKAVPDGQDEGAEKKALRPEEEAGIAGDAAPGTAGRDATQEPTPAAAAAEPFDNSTYRNLQHHEYSTYTFLDLNVELSKFRMPQPSSGRQSPRH
The following text describes a protein:
Function:
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
Subcellular Localization:
Cytoplasm.
Sequence:
MIILILNCRGFSIHFQLFDWSTRTVLARGDVDRIELGDSFISMEVPGRDPYHLESDCSSFGAAVALILATLTHPLEGPLSRVEQITAVGHRVVHGGERFTSSVPIDGKVIEAVRSVEELAPLHIPPNLAGIEGAMATLPGIPHVAVFDTAFHQAMPLHAYLYPLPWEWYEQHGVRRYGFHGASHCHAARRGAALLGREPALCNLVTIHIGNGISLCAVEGGCSIDTSMGLTPLEGTMMGTRCGSIDPGIPPFMMQEEQLSPRDLDRILNQRSGAAGITGLKLDRSAFLARAIAGDERCLLALEMEAYRLRKHIGGYAAALGRLDAVVFSAASGEGEWLVREKALADMACFGIRLDRERNRTARSVDREERVSADDSPVAVYVIPTDEEMVYAEEVAALLNGQG
The following text describes a protein:
Function:
Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (By similarity).
Subcellular Localization:
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Sequence:
MTTARDNSATTLELYRKTLNFNVIGRYDPKIKQLLFHTPHATVYKWEAGENKWNKLEYQGVLAIYLRDVREQAELPVPHQEASAGAEGRCGEVLSGRDIYNYALIVLNRINPENFSIAIAPNSVVNKRRLFSPEENVQQPLEPMDVEVKDELVIIKNLRKEVYGIWIHTPTDRQNIYDLLKYLLENEPKDSFA
The following text describes a protein:
Function:
Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
Miscellaneous:
MISCELLANEOUS: Binds 1 calcium ion per monomer.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MEVKMIILLFQILAISTLKSDSADIPEGYIQENVALRGRATQSAQLKGEFAGFAHASNAIDGNRDSNYHHGSCSHTEGDNSWWRVDLKQVYTITSVTITNRGDCCGERISGARILIGKHLENNGINNPECSTINIMAAGETKTFHCPQPMIGRYVTVYLPKAESLQLCEVEVNVLFPAPC
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MSSSSGRRSSPPARPAASSSGQKRARGDDDPGTSLVSNPASTSASAPAPAQNPRRAFASSPFADFGSYMSAKNSKLSAQFDADASTSAAAPGALFAGVSIFVDGFTVPSSQELKEIMLNNGGRFVNYFSRHTVTHIICTHLPESKMRNMRAFSKGLPVVKPGWVVDSLAENRLLSWVPYQISQHNSSSRKQMKLSAFFSGKQNGIQYQGNQNDENKDLEFQTSSAQEGSCDQTESCEQEGPLLNVEVAEDSLSSDEHRVPLMNVEVAEDSLSSDEHEVPLMNVEVAEDSLSSDEHGVSTFEERDGEDFAVAEDDNACKIAFSESMDNDMDPELHVAQSPDATSRCSDVCGTASVGSHLSIGSLEKDTAKSSSRSHSALTDPNFVENYFKHSRLHFIGTWRNRYRKRFSNLPGAKSSKGNNDHSGKKKTIIHIDMDCFFVSVVIRNRPELHDKPVAVCHSDNPKGTAEISSANYPARSYGIKAGMFVRDAKARCPHLTVVPYNFDAYGEVADQFYGILHKYCTKVQALSCDEAFLDMTECLHDNPEEVTEIMRNEIFGTTKCTASAGIAENRLLARLATRSAKPNGQLFISSEKVDDYLSTLPIKALPGIGYTVSDKLKSKEVEHCGQLRNISKDALQKDFGKKISNMLWNYCRGIDHSVVEAVQETKSVGAEVNWGVRFNENKDADNFLVNLSKEVSLRLQGCGLQGRTITLKVKTRRKGAGEPLKFMGCGDCETMSRSTTMTGATDNLVTLQRIARQLFAALHVDVKEVRGVGLKMSKLEHADLGRGAQQGNMLKSWLGSSSEKLKKQCSERTCFLGNSDGAGASTSEIRNLGSSRPSLTGVASHSSKVKLTSGRSTRVHAAELPPLSELDLEVLKNLPPEIISEMNDMYKGELHGFLGTIKGDEGKESNSKSRVLPAVNQNSVPVCNARLHQYGERTDSMHLEKRNNIKGASDQEVQTAHASCSRANELIDTESVTRLDFMPNSLSQADFTVLQELPEDVKADLFNVLPLHRPMDPTCRTSNITENKSLKNGGADDPKNPVICVLAGSSQKWAEQFRVSSSLLLNAIAEQHANSISSQPLSSILEHVASLLPLCPTSGSEEWSDTFSRLSVLLTEYVHLKVDSDIEELYKCFLLLKRFSSASELFLELHNSILPLLQDSITQHYGGTLRL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MSPMPALIEEGRAKVNLSLRVVGRRADGYHDLESVVAFADCADRLTLEPGGELKLATTGPLAAACGDTADNLVFKAAKLLAEAVPNLKLGAFALDKVLPVAAGIGGGSADAAAALRLLARLNNLSLDDPRLQKVALATGADVPVCLYSRACDMTGVGEQLLPLALPSMPCVMVNPRVPVATKDVFQALGLRNGELLVGATSVIGAPAWPEEGASIADWVEVLETVANDLEAPAMRIEPVIGEVLEALRDSAGVKLARMSGSGATCFAIYGAPAEAHAAAEKIRRDHPGWWVHAGTLS
The following text describes a protein:
Function:
Involved in L-cystine import. Low affinity L-cystine transporter that is mainly involved in L-cystine uptake from outside as a nutrient. Is the primary transporter at high concentrations of cystine. Probably functions as a proton symporter (Probable). Can also transport D-cystine, cysteine and homocystine as a methionine precursor. Mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys). Can also transport S-sulfocysteine and is required for growth on S-sulfocysteine as a sulfur source. Plays the principal role in the 3-mercaptopyruvate sulfurtransferase (3MST)-mediated generation of endogenous hydrogen sulfide (H2S).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNFPLIANIVVFVVLLFALAQTRHKQWSLAKKVLVGLVMGVVFGLALHTIYGSDSQVLKDSVQWFNIVGNGYVQLLQMIVMPLVFASILSAVARLHNASQLGKISFLTIGTLLFTTLIAALVGVLVTNLFGLTAEGLVQGGAETARLNAIESNYVGKVSDLSVPQLVLSFIPKNPFADLTGANPTSIISVVIFAAFLGVAALKLLKDDAPKGERVLAAIDTLQSWVMKLVRLVMQLTPYGVLALMTKVVAGSNLQDIIKLGSFVVASYLGLLIMFAVHGILLGINGVSPLKYFRKVWPVLTFAFTSRSSAASIPLNVEAQTRRLGVPESIASFAASFGATIGQNGCAGLYPAMLAVMVAPTVGINPLDPMWIATLVGIVTVSSAGVAGVGGGATFAALIVLPAMGLPVTLVALLISVEPLIDMGRTALNVSGSMTAGTLTSQWLKQTDKAILDSEDDAELAHH
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDAELLAVGLKDCSLHPQAKTLTKSRALHETFKNYLESVVQGTRAGSTAVVSLKNKVLSLDNPFKTTAAETSEKAITAASKKQTAKLLSARRRRELGLHLLSGNMKYSDAILLNDIWTKFVRQIIESEVGVVQDVTVEAQRTRNTKLQAKLKYLDLSGCPLEVIQSQNPCKVGLNGIVVAETQHTVQICCLAATGDDKDDGPIRTLVKLDSRFKLTFVDSEVVAGMGNIARLLLLGVAFHALCILSIFDIHFQSPVESSIPSNEYTLTPPAKRVIIFTLDGHADRYDLNAESASTSTKFASNRRTPYLGDVMRNRGSWGVSHNHAPTESRPCHVALTAGMYEDPHAVTKNWKQHPVPFDSVFNQSSSAFIYGNKDVAPILARHAPQATEEHYTAKEEVDMVREDTTLLDVWAYEKMKDLFARGAEAKDPDLYKKLHQDKLVIYCHYLGTDLTGPKFGADSREYLENIAVVDELIEKTEKMIDAYFGNDRRTAYVLNSDHGMDLRGDHGDKDPSKTRTAIIAWGAGIHRPVVVNRTGDEGFDFDVPTQSKAEVQVRLESQETEEQVAAQEWRTLIHFKRKDVMQIDVAPLISVLPFTYLTKNKYRVNAMRANAQQLYQHALRKEEVKHANRGLLFIPYAPLHSRVPDLMAHIDEALNSIPASDAPKIPSVVAVGPHD
The following text describes a protein:
Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome.
Sequence:
MGDGGLPLGPQPRNLSTPWPPPDGAPGSSRPAGPAASAPAGPPWSQQWTAGVGLLMALMVVLIVAGNVLVIAAVARTQRLQTLTNLFIISLASADLVMGLLVVPFGATLVVWGRWEFGSFFCELWTSVDVLCVTASIETLCVIALDRYIAITSPFRYRSLLTRARARGLVCGVWAISGLVSFLPILMHWWRAAGDEARRCYDDPKCCDFVTNRAYAIASSVVSFYLPLAVMAFVYLRVFREARKQVKKIDRCERRFYGGARPPSPTAPTAPRARSPPPRPPSPPAPPAPPPPPPRSPSFPCQPPPSGLPNGRPGKRRPSRLLALKEHKALKTLGIIMGVFTLCWLPFFLANVVKVFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRQAFQRLLCRPRPASRRHGRHGRPRRRHRLLLLLLGAGPEGRPPPAPRHPDPDPDPDPAPPWTGCNGGAPGDADPGRDACSESQL
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEPDQTYGILCCSCGVPIEPNPTSMCLPCLRARVNITKGIDTEQTLIHCHQCNRYNVGNEKYVAAELESPQLLGICLKKIRGLQHVRVVDAGFIWTEEHSKRIKVRLLIQAEVQQGAVLQQEHICTFTVVSTLCVPCQYTHTEHTWSTRVQVRQTVNHKRTFLYLEQIILHNRAKLNISNIKEYPHGLDFYFTSRSDAGRFVDLLHNSVPGRHSESQKLISADLKSNTATIEYSVMFEIAQLCKDDLVYLPRRFYNQLGGLGPLCIVSKVNSRIHFVDPLTGNTGSLTAAQYFEKPFTAFRDRRHKVEGIVLVSEEENSSGKRGQGSPIAYVELQRENDMYEGVTVHTKTYLSSLCKPGRSVAVYSLDNLDFQAYGITPSDIYLNLRVVIAGKWKGTKQHSKHKLARYETEEGVAIVNAPDDDINALLEEMYDDETRDRELDALMNNLGQLNLMQPPSSGCMHSAPAASNTLTYMPFTSVSGIQYQGFCPQ
The following text describes a protein:
Function:
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane. Note=Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes.
Sequence:
MENGAVYSPTTEEDPGPARGPRSGLAAYCFLGRLPLLRRVLKGLQLSLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFVTMLYEKRQESQLRKSENTTRAEALTEPLNA
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MWYHKLLHQQSRLQNLMKRGDIAHGLRLSGFKSLFPFSLHWCHTASKSVNCTWHQHEDHLELQYASTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDESTLFFTWPDGHVTRYDLDWLVKNSYEGQKQEVIQPRVLWNAKLYQDAQLPSVDFQGFLETKEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLARRVSLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAQQVLQRAPEEFDLLSQVPLKHEYIENVGQCHNHMIGVGPILNIYPWNKELYLIRYNNYDRAVINTVPYDVVRRWYAAHRTLTTELRRPENELWVKLKPGKVLFIDNWRVLHGRESFTGYRQLCGCYLTRDDVLNTARILGLHA
The following text describes a protein:
Function:
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. A Cbi(MN) fusion protein has about 70% import capacity, but the holo-Cbi(MN)QO complex cannot be isolated, suggesting CbiN may destabilize it.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MHIMEGYLPVTHAIGWSLAAGPFVVAGAVKIRKIVAERPEARMTLAASGAFAFVLSALKIPSVTGSCSHPTGTGLGAVVFGPSVMAVLGVIVLLFQALLLAHGGLTTLGANAFSMAIVGPWVAWGVYKLAGKAGASMAVAVFLAAFLGDLATYVTTSLQLALAYPDPVSGFLGAALKFGSVFALTQIPLAIAEGFLTVIVVDALAGKVDDKDKLRILAGEAR
The following text describes a protein:
Function:
Catalytic subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase. Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MAATAVGPGRSTSSYSEVQHNRLIVSLPLPSVLKKPFSVIDGPPSSAAGNPGEIAKLFPNLFGQPSVSLLPGHTSGAALDRTLKIGVVLSGGQAPGGHNVISGIFDYLQEKTKNSTLYGFKGGPAGIMNCKYVELTTDFVYPYRNQGGFDMICSGRDKIESDEQFNQAAETAKKLDLDGIVVIGGDDSNTNACLLAENFRGKGLKTRVIGCPKTIDGDLKSKEVPTSFGFDTACKIYAEMIGNVMIDARSTGKYYHFVRLMGRAASHITLECALQTHPNITIIGEEVAAQKQTLKSVTDYIVGVICKRAKLGYNYGVILIPEGLIDFIPEVQQLIAELNEILAHDVIDEAGSWKKKLQSQSHDLFELLPQAIQEQLLLERDPHGNVQVAKIETEKMLIQMVEAELESKRKEGSYTKQFKGQSHFFGYEGRCGLPSNFDSNYCYALGYGAGALLQSGKTGLISSVGNLKAPVEDWTVGGTALTSLMDVERRHGKFKPVIKKAMVELEGAPFKKFASLREEWALKNRYFSPGPLQFVGPTSNETNHTLMLELGAKA
The following text describes a protein:
Function:
May function as part of the axonemal radial spoke complex 3 (RS3). Radial spoke complexes are important for ciliary motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium. Cell projection, cilium, flagellum.
Sequence:
MVKEKKKADKKGEKSARSPSSLSDNLDFSKQDGNTTRQEMSPAGVPLLGMQLNEVKPKKDRQNVQQNEDATQYEESILTKLIVESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGFPDLEVEFISCLDLSSGVAPRLSRSAELIRKLDGSESHSVLGSSIELDLNLLLDMYPETVQPEEKKQVEYAVLRNITELRRIYSFYSSLGCGHSLDNTFLMTKLHFWRFLKDCKFHHHKLTLADMDRILSANNDIPVEEIHSPFTTILLRTFLNYLLHLAYHIYHEEFQKRSPSLFLCFTKLMTENIRPNAFQIKGNLFREQQRTLYSMSYMNKCWEIYLAYCRPSAAPPHEPTMKMRHFLWMLKDFKMINKELTAATFMEVIAEDNRFIYDGIDSNFEPELVFLEFFEALLSFAFICVTDQMTKSYTNVPADDVSGNKHETIYTILNQDAQNKSPSAVMSHESDAAHSDSARSSSSKLELSPDVNKIRKSEPKIKKSVSHERVSKMNFKLTGKGITFFSSESKKYERPKDDREEEFNTWVNNMYVFFVNTLFHAYKREEAIKEKIRADRLRSTAQAQQRKMEDDELEARLNIFILREEEAKRHDYEVDITVLKEPADVSSSHLILDPPKEDVTVSPSSKTITSKKKKK
The following text describes a protein:
Function:
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MKVAVGTVNPVKVNAVKNVFGKLFDNVEVEGRKVGSGVPDQPFGSETIKGAINRAKNAYRTGDYDYGVGIEAGLTDVEGYVLDIQFCAVFDGLDCTTGCGSGFQYPPTVLAEVLTGREVGDVMSELTGIENLGQKMGAIGYLSRGMLDRTQLTEQSVLMAMIPRLNPKLYRQID