lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Localization:
Secreted.
Sequence:
MVKLIVCCLLAVLSSSVMGAPADDTLATLQELLKDLKHLSKNIKHDGRMLNTPLIEDIEDCCIPSALRCFKEMLPGLTTTDEQKSQKVKKMCYKMSNKTIDRTGNVCTPEEVEKASCRACDSYEMKDSKDFLNAMEKLLQKSVMKMQ
The following text describes a protein:
Function:
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
Subcellular Localization:
Cytoplasm.
Sequence:
MKRTLISELKNFMNEKINLQGWIHKIRKLRNITFLIIRDRSGLIQCIVDNDKLDLSQVKIESIVSLTGVVKESTNALNPFEIQVENLEIINAALDKLPIEINKENLEINLDTMLNNRILSLRHPKVNSIFKVQNSIVNGFREFLNKEGFTEIYTPKIVWEGAEGGTEVFKVKYFENTAYLAQSPQFYKQMMVGAGFERVFEIGHAYRAEEHNTNRHLNEYISMDLEIGFIEDEKDIMEVEERLLKFILEKLNKECKEYFDLLDSELPKIESEIPKITFKEALDILIKEYNKNNLTCDLDPEGEKLICKYAKEKLDSDFIFLTNYPREKRPMYTMPLGKDGTHSFDLLFRGIEITTGGQRIHDYNMLVDNMEFKGFNPKDYESYLSAFKYGMPKHGGLAIGLERLTSRLLGLENVREAALITRDRTRLLP
The following text describes a protein:
Function:
Required for structural maintenance of centrioles, ciliogenesis, and cilia-based motility.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MKKTTIASSAVASQKQTQSKLGNTSSKITEQQTTHDPALSRSFRGHEDIITCADFDPKMRQVASCSKDSIVYVWNFKPQQRPFKFVGHKGAVYCVKYSPDGETIASCGQDRQIRLWQNTVQSKCSIIKAHCGAIRSMSFSADGGYLLSSSDDKTLKLWRLQDKKFMCSFAGHKNWVRSGVISPDMRLVASGSDDKTVMLWDLNFQKIVSKYSTLDDNVKISQINSYSDHMDTVSQVLFHPDGTCLISSSFDHKIKITDIRSNKLIQHYNAHDAQVNSISIHPTGYFLASAGSDSKIKIWDLRQGRQIYTLYSNDKDITTVQFNQSGDYFATGGSQNLCMVWKTNFDQNIQNIEQVQRSTVRQNDVEYSSGGLYAQTLFKTNKTASLSPSKKTISIIPPQQLQDTFNNRGDDELNNGRVHENKQSNSPTFSQQQQQQQLNLSENQYPGLEIVGNQFNLQQSTLSNNNNQNNLIKSQNDSIVSNKNAIPFHPSSEFQQSAVQQQFSQQPKLVVNNGTATYPSNFVPKVEEENIMTEAIAASMQQIYSRLDTMFQYMTNLENRVVQSEQLQKSFVSQNHQNTLDPKQQTMNFGYSNIQDHSLSASLNDRNVVNIFQAGALANTGSIEASLINKQQEE
The following text describes a protein:
Function:
Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein.
Sequence:
MKRQVGAEESKLCRKLGVFMRKCVFGILSVGVIPNHIAFILDGNRRFAKKHNLAGEGAGHRAGFLTLMSLLKYCAELSVKYVSIYAFSIDNFKRTQNEIRYLMDLMLEKMEFLLREDGFLSKYGVRVCFIGNLGLVSEPIRVTAEKVMRATSKNTRIVILICLAYSSTEEIVHTVEETCLVTKKTQPQAFKPRNPQNDVTEDADEHKNKEQNTIKLVDLEKHMYMGVYPNPDILIRTSGENRLSNFLLWQSSNCMLYSPAALWPEIGLRHLIWAILNFQRHHAYLEKKKKQL
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MYIKWVVGCLLITCFVQLEASPGDRSIWYQECTQVCISKYNCSTKFGTLDWARGDCFWCRYDCMWDTIGHFDSNFGVVPQFHGKWPFLAIPLPFGFIIQEPASMIFSLLNLFTVYKMLRRFKKMQNLPNRTMWLVYAHVGMFTWISSSLFHMFDCDFTEKMDYFGAYSFVLFALYVSVIFTKQLQFLGRGGPKYIQILFALVYLNHFMKMMQNFDYGYNMTCCIVFSLITTCLYVHHLYYRKRNLGSLQESDIVLIRLIIWANLSTALEILDFTPVFWIFDSHSLFHLATIPIPIWWSDFLALYYDLDVASGKRSVLKMA
The following text describes a protein:
Function:
The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity.
Sequence:
MATQTKKPQPTQLLSLPNSKESEMIVLGCMLTSVNHLNLAANLLQEDDFYFLEHRIIFRVLQDAFKSDRPMDPHLTGEELKRRDQLNIIGGPSYLITLSEFAGTSAYIEEYAEIIRSKSILRKMIQAAKDIEKKAAEEPRDVTTALDDAQNLLFRISQTTNLAPHVLVADKLKGVASSKDKSFLLALQERQEAFQASAHDSSSPMLSGFPTHFLDLDKMISGFSPSNLIILAARPAMGKTALALNIVENFCFDSRLPVGIFSLEMTVDQLIHRIICSRSEVEAKKISVGDISGRDFQRVVSVVREMEEHTLLIDDYPGLKITDLRARARRMKESYDIQFLVIDYLQLISSSGNLRNSDSRNQEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRPLMSDLRESGSIEQDADQIMFLLRREYYDPNDKPGTAELIVAKNRHGSIGSVQLVFEKDFARFRNYAGCEFPG
The following text describes a protein:
Function:
Specifically methylates the guanine in position 2445 (m2G2445) of 23S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTLYTLFATCPRGLETVLSQELESLGCTDVQVFDGGVSCRGGLEQVYAANLHSRTASRILLRLTKGTYRNERDIYKLAKNINWFNWFTLQQTFKVKVEAKRANVKSIQFVGLTVKDAVCDAFRDIYDARPSVDKAAPDVRIHAFLNERNVEIFIDTSGEALFKRGYRLDTGEAPLRENLAAGLLLSAGYDGTQPFQDPFCGSGTIAIEAAWIAARRAPGMMRRFGFEKLQNFDKTLWSDLRRRAEAQTRPVRAPIAGSDNDRRIVQTALDNARRAGVDDIVSFSVADAQSVRPNGENGIMVSNPPYGVRLEEVRALQALYPQLGTWLKKHYAGWLAAMFTGDREMPKFMCLSPKRKIPLYNGNIDCRLFLIDMVEGSNR
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MESAVKTLVSNFSSTIKSYKQFEHLRTKAPSSQVRLFYGDMIDVSRKPQKRNQIAYFTTIPFAAVPTTVVLSDLEEDTSDEGGVVTTEINNSRDEIKININVPGSETQSIFDTVFSKMVAAAQPIPGFRRVKGGKTVNIPKEILMHILGPSKVNKKCIKEIINSSVAEYVEKKGLRVSKDLRVEQSYEDLEAAFQPGKDLSFDANVRLLDRQ
The following text describes a protein:
Function:
Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments. Potential oncogene.
Subcellular Localization:
Nucleus.
Sequence:
MEQRRVTDFFARRRPGPRIAPPKLACRTPSPARPALRAPDSATSGSRKRARLPAAPGRDQAGPPARRRLRLSADAVSSPSSPEAPDSLEAPDIPACPSLGQKIKKSTPAAGQPRQLTSSQNQDTISELASCLQRARELGARVRVLKSSAQDAGESCTPEAKGRPEEPCGEKAPAYQRFHALAQPGPPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEERNVGQIKTVYPASYCFRQERSVPTFKDGVKRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLASLRPPMVVPEDQLTRWHPRFNVDEVPDIEPAVLPQPPATEKLTTAQEVLARARSLMSPRMEKALSQLALRSAEPSSPGPPRPALPDTPPATPPAASPSALKGVSQDLLERVRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCRTAMSPGEMEKHLLLLSELLPDWLSLHHIRTDTYVKLDKAADLASITARLARQARAEEGL
The following text describes a protein:
Function:
Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTCIPPGGWPQPQSLYVHVPFCRHRCGYCNFSVIAGRDELQDQYLDAVERELKGIDNSSHELPLRTIFLGGGTPTRLSATRLQRLHRAISNAFPIADDAEITAEANPEDISPECLDALQAIGVNRISLGVQSFDAEKLRCLERGHDESIALSAIESAHRRVGNVSIDLIFGAPNESLATWQNDLSIAAASSISHVSTYALTFEKGTSFWSRRSRGDLSETDETLELQMYEAAQQQFSIDGWQQYEISSFARGATRCQHNLAYWAGRGWHAVGPGAARFVDGRREVNHRSTTTYLKRMLAGGNATDETEAITLEQYARELAAFGVRQLDGIDLSTIDNRTSIDLETLLAKTLTKLQSMELVTHENHHLRLTCRGILFADTVATALLSEPE
The following text describes a protein:
Function:
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Sequence:
MAKKTVAAKKRNVKVDANGQLHVHSSFNNIIVSLANSEGQIISWSSAGKMGFRGSKKNTPYAAQMAAQDCAKIAFDLGLRKVKAYVKGPGNGRESAIRTIHGAGIEVTEIIDVTPLPHNGCRPPKRRRV
The following text describes a protein:
Function:
Catalyzes electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDKKLGLGSLTALVIGSMIGAGVFSLPQNMAAVASPLAVMIGWSITGIGMIFLALSFQYLAVNKPHVNSGVFGFAREGFGDFAGFCSAWGYWFSAMVANVSYLVIVFSTLGLLFDTPDQIIFGSGNTWWSIGGASLLLWAVHSLVLRGVQTAALINLITTMTKMVPLLLFIVSAIAAFNWSTFSLDFAGLHHISGADLLGQVKATMLITVWVFVGIEGAVVVSSRARQRKDIGRATILGLLTALSIYVLVTLLSMGVIQVNQLAQYPNPSMAQVLTTIIGPWGKYIIAVGLLISVCGAFLSWTVLASEAPFLAAKDKMFPRHFAKQNQAGSPVNALFLTTLCIQVSLILVRYTSSTYDSLLIFASEMILVPYFLVGAFTLKLALEQRDRGKLLLIGFGATAYGLWLLYASGLHYLMLSTLLYVPGFAFYLKAKREQGVKAFCGREMVGASTLLLFAVGAAGMLWQGAW
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MTSKFFCFVLIIFALCLISVRSRPLAPNLHSLQNKLSTNEGNMSNEGQGQVKETEEYTDMNKEEKKMIGSSPPSCEHKCYGCMPCEAIQVPTNTGRVGVQYTNYEPEGWKCKCGPAFYTP
The following text describes a protein:
Function:
Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA. Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. May play a role X inactivation in females.
Subcellular Localization:
Nucleus.
Sequence:
MNSRGIKYHFHKGERVLCFEPDPSKAKVLYDAKVLDVLIGTDEHGRRVPKYLIHFNGWSRSWDRWAAEDHVLRDTEENRKLQRRLARKALGRMKRKGWRKRRRRPSGTKSSSLKTLPKEDDSDDACLISSSESSEGDDSDPDDSSNSGDSTFSEDMNKMRVEPELNIKRECEEKTVHVDISIPDVLKKKLEDDCFYINKRKKLVMVPCQTNVVHILESYVKHFAINKAFMANERYRRQQSATQSSSPQPTPPEKSEELCKEMVDGLRITFDFTLPMILLYPSEQAQFKKVSSSRLFLTTREGSPCSSSFQRERSPSPPVHNPPTPQSTDSQPTLSDTSATTPTAPAPTPKRRRHPDMDCISFQSQSQSLRRSTRNTSGGDRPAEGSSGGGGSAAASPQLKRRAVESSSQPKFFLNLDKKTPVHSGSSSPLPLTPSKERSGPFRGLESRRNNELNEVLSWKLTPDNYPLNDQPPPPSYLYGSQHLLRLFVKLPEILGKMQIPERNLRTLIKHLELFLRFLAEFHEDFFPESAYVSASEAHYSMKQPRPVY
The following text describes a protein:
Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins as substrates.
Sequence:
MEKQKRKEGKRFQFRLNFKNKKITLKLKNLMAIRPLLLEQFRILNHHHHHRYHINKNSNNNKPPISLFFSSKAKNFYLPSPSPLFSPQSPITSVLRLASTSSHRKQHLPPPPPPPPPPPPLQPIAEAIRLHRLKNSVALSSETLAQKIGKSIRRPGAPSKARVYADVNVIRPKDYWDYESLTVQWGEQDDYEVVRKVGRGKYSEVFEGVHCADNEKCVIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQQSKTPSLIFEYVNNTDFKVLYPTLSDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHEQRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDLWSLGCMFAGMIFRKEPFFYGHDNYDQLVKIAKVLGTDELNAYLNKYRIELDPHLAALVGRHNRKPWAKFINMDNQHLAVPEAVNFLDKLLRYDHQERPTAKEAMAHPYFYPIRNAESSRVRT
The following text describes a protein:
Function:
Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
Sequence:
MSVQPDPVTQQNEENLDWTQLLDEYDYARPQRGELREGLIMHIEESGVLVSIGTKREGIIPAQDLRQMGEDFINSLKVGDTVQVYVQEPENRDGDLILSLSMVQVAKDWEVAEQLFHDGGITRCKVIGFNKGGLLVQFNRIRGFVPSSQVAQLHGRTAADERQQALQKMVNQEIPLKVIEVDRERNRLVLSERAATQEWRKAQKHRLLTELQPGDVLVGRVNQLTNFGAFIDLGGADGLAHISELSWQRVNHPREVLQPGQEVKVVVVEIDRERERIGLSIRQLQNNPWETIDQRYTLGQLVTGPVTNVTPFGAFVQVEEAVEGLIHASELDADPQAQPRDILQPGQIVTARVISLDRQRQRMGLSLRRIGENENEPAPAPADEADQPAQA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADIVEEQMGDILSAFGIPDLAKHIFPIPLPPLDDEDDDNEVKEKPKDESKENHPKEDKPKEKEGEGEKEGEEEADKEKDASDAAMDVDKSGKDGDGKDKVTKSTGEEEIKDDQGSIEEDAAMETDEGTDSSAAVSQNEDEAPSQDGKTETSTEQPQKDIPDLGLKQSVASLHEGETTNQESSLIKQLLKSTSKPVMTSRLQDDLPPPDASFGVPEEPDVEEPPLESLTSTDDFNSFLDRCKENRELMGMKIAIMGRASCVSTYQCPNLTEEQMKVLDMGKEIFQCPGCNDTYLFKASLDAHLDRRTVLVTFRCKWCTGRQNLVFYNKCTFLAHLHNHDATESEIEKVKLQASISPVNALDCFKIFTKLTAPVKMDAASKPTVKKSSIPSNTPHLKSQSLVSLQATSKSPHALINQGNTTKREAITMFPNNMDKVIHLDKLSSFVCMGCKRRYERLSHLRAHLDRPHPEPSTPGYKGPLQQCTICKLVVANACKLIMHNIIHTAEIKTPIPCPECGCLFTDLKSLLIHQNDGCLHWMTRPLFKCSFCTKYATTFQGLIKHFEQNHVEVFFKCPLCQLAFRNNQSASEHSLQVHKLTTVTYSLLRKCPFCKSVYSERGMLSNHFDCHYQAGLIKIEKFVFSCPLCSKPFDFGRTLRKHLADEHGRSSSNMFNCDLCLCSFSTIDSVMHHRNVCAMKPKIKISTKPAQPEEKNAAQPTNKPVVCGECGDMIPNMNTVQKHMFEKHKDKMEMNLAGLKKKQEVTTVAKDKIEAIKPKGTEELVKTPVVAKREAPLIVERFTDLKCGKCQFMRRDRLLFEKHILGHKTEDSLSQCHQCGLCFTVEGSLKKHLFIKHRIKNMALFNSFYEDHMPKWEEDMKKKKVEEKEKESTRSEINEENEGKTKVPAEAKDEKMEEEKVDETSLFKCKVCKVEFENDKALTVHARSHGLAYLQHTLTKSPEKAVRMQVSKPAASPIKMEERSPDVADKPEIKPIVPPSVKGTIPSDTDSSISSEDISSIDGQNGD
The following text describes a protein:
Function:
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
Subcellular Localization:
Mitochondrion matrix.
Domain:
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
Sequence:
MTVLQRPLRAIIMGCPGAGKGTQTKWLASNYGIRTISSGDVLRSNVLQKTPVGLQAKAIIEAGGLVNDSLVNDLMLTEMKGMSDSQCYVLDGFPRTVPQAEMLDAWLKQNGTPLAMVINLDVPWNVILQRIEDRWIHAPSGRTYNISYNPPLLSGRDDVTGEPLTKRSDDDVDIFKSRLEAYRSQTMPLIGYYTNQGILCNFKGSTSDEIYPQIQDTLHAYYGCSITADTKPAKTCTSTDSTSVSTLSQKPLRAASVA
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor mdn1 (By similarity). Also required for heterochromatic gene silencing.
Subcellular Localization:
Nucleus.
Sequence:
MSDLLERGSLPLVKSWLAITFANEEDLPFQVPQIADILVHQKCIERLGTSENALSVRKNWCTSLTKMLQSKDFRIRWSAIILIHCTISQSWDCLVEHGATWAKLLIALLNRPETPKTLEIAMITVSKMFSSTVGRPAVTRELVTPNLPTFVNNCLRIAESGKCLCTVCSCLYQGIISHSPTFRPFVSSIRNICIKILDGEEVVPSSLQKKAAVLYASLYRCVGKGNFEDYWKQSIISILKEYHLTLDFLFQFVIEPQTYPTREENLMFPKLKGHYEETYQKALHRCRTLNLILISFLSTKTDKIVLLPINALKDLIQRVYTVQLSLPVKSVESSVQALLFMVLPHLHTLVNELTLKLFVVIPPAIILSFDSYLDSLNDCLLSESTHTGVLCSSLKLLSKFLDVTHMNVPLSKYENIVTLVLEYLANSSKGLASKSIEFSKNRGHSQKKRKTLSESQAGDTLMSSEESHQLYDSDVMDCCFSFLASILTHSIALPRLLRTKIDLCTLQISLSNPTSTVLISMHNLLLASILSPGDSQAVIVPHAIRIISGPLGLVHPDPLVASHARSSMQTIESLIHPRFPPLQKHLSPSEFENTFESRFEPVSLENQSHISPPQVDSQSEYKESSILAPSNPPFETESITDSTEIEGIKESFASTDTGLQNNSTATSENKRSESELTMSNVLSNEGDRNEEGSEINSSQPSTINHGTDHINIVSENKETTVSLLHGDVEVEETTNVALNNSQDTETKFTAIDVDFVDRPTSVVSSQIENINGDENGNTTSSVVETFEKTTDVVDEKTTSINVEGNGEDDEEEDNISLPSINLESDSDS
The following text describes a protein:
Function:
Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MADQGDDGGPPKKKFDMESWPEAYTYNPGGDNSHLNPTMKAILATYYYTVDKPVTAIHDWIKSQKRVSYPYYHRKFRRVPGIEECDVQDQVCIYEANEQFQRDHLVDQEILRLSRQDWTRCCFQEGDSHFVNCRDFKQRFDAAQNAYDTKYGDLGVYGNAMKAFMKQKHRMIEERREAEKQEA
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Sequence:
MAAPGSSAEAQPSGGPAHAAVVFVGHHQAGKSTIAGHIIMKLGGLDKRLLDRVERDTSNRPASRYAWVLDRHKLERDRAMSVDLKICRVAAPPGAAAVAAAAGLEAAGGEGGLSLTLLDTPGHPDYLRNTIAAITQADVAVLVVDCRPAVLESASSAAQGRDLALLALNLAANHKTLVVAVNQLDVAYESEAAEARFNEACAVLPKMIRQRKESLVFVPVSGYTGDNLVKAAPARMPWYSGPTLLEAIAAAAATARPAAAAAAAAAAAPGGVAASELPLRLPILNVYKVGGIGTVPVGRVAGGSLRRGGAATLLPGPRSRGLPQQGQQQPQAAPQAAPQASAQVQAQASAQPPQPQQQAGAPAAAPAPAQPAPTSHASAEAAQAAAPPAAGDGVEAGPGGAAAESSSGAGGPSTAVAVAAAAPVATAAAAGSAGASGQGPAPGAAVPPVPASASASTAPVLPIRSIEAFHDSRAAAVAGDFVGVAIRGLPVAALRRGHVLCGGGGGGSGAAGAGGGGGGGGGGGEPACVAASFTARVQVHRDPTSKRPHPSAATPPGMAVGRYVPLVAIHTAQAPCRLLRASKLNTKGEVVEADVKYLREGDIAEVELAPLRPLVVEPFRSYPHLGRFAVRASCRQQMRGVGVITPVVVAVGRVESVNYVRLEDFSPPAAPRDVLAKRTARKARGASGAAGFDDTAAGGAGGEGAAGAGAGEAGERVTIDMSGEAEEGGGPE
The following text describes a protein:
Function:
Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation. Also forms a holoenzyme with processed ced-3 enhancing ced-3 activity. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1. May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway. Regulates CEP neuron apoptosis in response to high Al(3+) levels. During male tail morphogenesis, promotes apoptosis of the tail-spike cell. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and ced-9 and upstream of ced-3 apoptotic pathway. Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3, regulates temporal cell fate patterning during larval development. May play a role in resistance to S.typhimurium-mediated infection.
Subcellular Localization:
Mitochondrion. Cytoplasm, perinuclear region. Note=In non cell death induced cells, ced-9 is required for mitochondrial localization. Perinuclear in cell death induced cells.
Sequence:
MLCEIECRALNAAHTMLIQDFEPRDALTYLEGEKIFTEDHSDLISNMPTRLERIANFLRAYRRQASELAPLIDFFEYNNQNHLKDFLDEYLWFATHQPDKLRPVVLVPKFSRQMLDRKLLLGNVPKQMNCFSREFHVDRVIEKLDEMCDLESFFLFLHGRSGSGKSVIASQALSKSDQLIGINYDSVVWLKDSGTTPKATFDLFTDLLLMLKRARVVSDTDDSHNMPDFINRVLSRSEDDLLNFPSVEHVTSVVLKRMIANALIDRPNTLFVLDDVVQEDTIRWAQELRLRCLITTRDVEISNAASPECEFIEVTPLESYECFELLESYGMPVPAIERDEDILHKTIDLTSGNPAALMMIFKSCEPKTFEKMAQLNSKLETRGLSAIECITPYCYKSLSSSLQRCVEVLSDEDRSALAFAVIMPPGIDIPVKIWSCVIPVDICSNEEDQLDDEVADRLKRLSKRGALLSGKRSPVLTYKIDHVIHLFLKHVVDVQTIANGISILEQRLHELGNNNTPTPERHMPSKFRRTSAGDMFPKVEDSVIRPEDYSKFMQIHRTFYDSLKKFTSQ
The following text describes a protein:
Function:
Required for sporulation. Required for meiotic nuclear division.
Subcellular Localization:
Peroxisome.
Sequence:
MSACPCNIVILPVEILKNSSKDTKYSLYTTINRGYDVPRLKYGIIVSPRVHSLETLFSDLGFDKNIEKSSLYLLLNDPTLAYPNFHEHFEQLKGETNKDLSLPTYYIPKVQFLTEAFDSEHTLATIGYKPNNKESYEITGFTSMGNGYGIKLFNYSVIHMMRSHKCKRVVADIIMEHDLLGYYEKKLGFVEVQRFKVLKEQHQVKVFDDKVDFTKDFHVIKMIKELGNHRL
The following text describes a protein:
Function:
This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
Subcellular Localization:
Cytoplasm.
Sequence:
MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNKLNEPWPDLILLDWMLPGGSGLQFIKHLKREAMTRDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEMQGLSLDPGSHRVMTGDSPLDMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEHSGHDRMVQTVRGTGYRFSTRF
The following text describes a protein:
Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
The following text describes a protein:
Function:
Sodium-independent organic anion transporter which exhibits high specificity for a subset of prostaglandins including prostaglandin E2 (PGE2), prostaglandin E1 (PGE1), prostaglandin F2-alpha (PGF2-alpha) and prostaglandin D2 (PGD2).
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
MDFDEILHHVGDSGRFQICMIILLNILSLVLSPHDVLENFTAAIPAHHCSINLDNSRSEVSTDMNLTTEDLMKVSIPMGPNQKPEQCRRFRYTQWQFLDSNISTFNSTELETEPCLDGWTYDHSVFTSTIVTEWDLVCDFQSFKYYAQATSLAGHLVSCPLSGIISDRFGRKPLLMYCSLAYGAVGTYCAFAPNFSVYCVLRFLLSAFQSTILINSLILVLEEASVQWHPTIIVLSGLFNSIGQGVLGGLAYVISDWHLLQLAYALPFFIFFVLFCWVPESVRWLIITGKTDQAWKELQRIASINGKKGIAQNLTTEDLRSKLKKDVNSTGKLFRIKDIFINPLIRKIVLSNSSLLFAELFSFVGLLLDVQLLGKNMFLTQIFLGAIDVPSKSLTYFTIRNVSRRPLIAFLLLTTGSCITITIFISEEMYVLRTIIFILGKGCFAAFTCISTTYINELSPVELRSTLNGVFLAVVRLAGVLSALTLATRKYFVYLPMILYGVLPIVATISILFLPETFNLPHTDIIKDMEKRKRLMSKNISKKEGQDFLETTEC
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MEQSFLAYLRGRTRQLPQVAVGIGDDAAVIDWPGSVSSDQPQLRQVACTDQILDGVDFRSEEQSLSDIGFKAMAINLSDIAAMGATPSSALVTLALPAENATEIAGEVYEGILEAAQKYQVAIAGGDLSTYDGPLSISITILGWTEQPWLRTGAEEGDALFVTGALGGSLLGRHLRPEPRVELAAKLKQTVNVHAAIDVSDGFSLDLDRMLAASRMGAELELETLPISEAAHQFAEKSGRTPLEHAWSDGEDFELIFCVAPEEAAIIESTDWGVPVTRVGKVVGRTGLWKRVATSKFERVFPQGFVHGETDVAAAN
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Subcellular Localization:
Nucleus.
Sequence:
MEMTSENRKRLSSSLKLVHAAEKLRVNPSCISTLRYVLKCLSNVEHLDIAAKQYVSLGFLDVIPSVLTQRSMKVVTIGLEILGALSLSSSKIHHQVLTKEEIIRALVEIFTSSNLDLLTAAFHTLEDVLITSDGLERFKHTSLVENLMRLLCLLADLYRKPDSSYGLEEEKRFDKSVAERGERLQVSDILDNLDGESRKRGSKRVFGNELESLVDSCVRTIVSINPGECIKSVPRFVYFKALGILYQHWSFMLEKDQLLYNNVDPTRGNWYRRSKSRHELAKCLVLLGMEYDCYPGKAGIVDEKSPGISDLSSDKFMDFWERLPVLVTKAMPSCLLTFAKRFNNMERLFNLLYSFTTCPSSSADEVDSFMSIREIECTVGDPLSYGRDIRIVKTVNDSKVMKLEETEVHFFSTDAECTVDKHVHPKAMLDAVKAGFSLAIKGLELRCADIARLSEALAKQFGQPSVGVNLYVTPPNAQGLAVHFDDHCVLVCQLHGKKSWKIFPPAKILPRLYASRSLDEEALNSCPANAVTLEEGNVLYIPRGFPHKAFCDDKFEEESGGVDGFRYSTDPCLGLDETSKSDVANLCNSAFPISGRKKKKQKITPPCSDSLEDQCELQTDCIDNGISVHLTFGVEVEPPFEWEGMVHIALRLWILQRWGSVHGSDSKIIKDEDWSEALLHVAIRNLGENDIRFRKACMIAAEALTDSCIEKPVNVRQNEKACGKNLVPRCGALDPLGCDSCSQSSLSYFQSLITMVDERINFSEAFSLAQSYFKSSKDEGDVVGMDYLRHVPNSSERFLDSRYLDPIYLLQHSSFEESACVQILTNMKAEFGQASMFHDASQVFRMILNQYRTMRRKYRNGMLALHGGLSQQENNADEKS
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDGQENYESSDGEQAIDLTETLANISKNQQQQHQALGLSDDDEDEFIRLSSKKANFKAGSKVLRATTNNNKKKNPATLTGGGSFQSLGLHPSLLRAILLRGFNSPTPIQRAALPHILASPPRDVVGMARTGSGKTLAYLIPLIQTLSGVHSVQFGIRALILVPTRELALQVLKVGKDLAKGFIQGDRSKPSTSQDSETNHKAEGLRWGLIVGGDSLEDQFTMFSTNPDVIIATPGRLLHLVVEMNLDLKSVAFVVFDEADRLFEMGFATQLEETLHRLPANRQTLLFSATLPKSLVEFAKAGLQNPKLIRLDSESKISSDLQMAFLSVKPIEKEAALLVLISNIVGVPKADTTEQPNESFNHQSQPNFSRGSGANLSKIRRKPTRELAAHQTIVFTATKHHVEYLGGLLVAAGYRVSLIYGALDQTARREQLDSFRLGQTNILVVTDLAARGIDIPILENVINYDFPSSARAFVHRVGRTARAGRKGWAYSLITQSELPFLMDLQLFLSRPLLACPLPANEDPSQTDFSSSLVIGTIPRELLDAETEYVRETLVSPNSALIALATVVKRAQKMYEKSQSTASNESHRRAKEFVLNGKGFSGAKNEEASIHLIFKDRKQELPSTQRGVKRTKKDDQTVKLRDQLLAKVNQFTPNETVFEIGTRGKGVAAQLMRDRRKSMGKKIAGSKEAAKLREDQLRAEQIIDPSPSLAKQTCPSGPSDKQVALVAATEGELEETFEMPRKKPKVKEGFRDPEAYLTYEQSGAAEEKGYNLNEGTSAEFVTQSKVALFDLGTNDEGKLACLSNAQKASQVKWDRKTKKFVKVGQVGQDNVKLVKTESGVKLPASFKTGSFDNWKKAQKIRIPNVGEQELQNTHPFNHLHRKFRHTSGAPSGPHDHQDRSTHSTGGRRDGRMEQNKRGKKVFTKTIDGQKKFLGPSHVVTRGPSSTSKSNFSGHARHNQHHKNSSNHHVSSSFSNKKGSASSSSRNNNAGLKSVDQIRKSRELKERRKIRSNQPSRRKK