lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
G protein-coupled receptor that plays an important role in immune homeostasis. Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (By similarity). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDPEETSVYLDYYYATSPNPDIRETHSHVPYTSVFLPVFYIAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVFLLTCMSVDRYLAIVCPVVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELTLIDDKPYCAEKKATPLKLIWSLVALIFTFFVPLLSIVTCYCRIARKLCAHYQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTSKLLAIVSGLQQERYFPSAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETSDSHLTKALSTFIHAEDFTRRRKRSVSL
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MALSEDEIFTKVQEALVDALGVDDDETTRDATLVGDLGAESIDFLDIVFKLEKAFDIQIPREELSPEDILTNSQYVQDGVVTADGMAELKKRMPWADLSKFQENPRVQDFGNLLTVGDLCNYVDSKVNQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MSSVPPADLDLTSIQWRMPEWVQAMGGLRTENVLEYFSQSPFYDRRSNNQMLKMQSQFNALDLGDMNSQLQRLQGIQFVIIHERPPDLWIIQKQNRLNPSEVKPLANYFVCNENIYMAPNAYTLLATRLLNATYCLRKALSDVKDIASFSPERGYSYPTNLSLDSELDESQQEDNLDDTVASENQETFAGDRQPNPPASEEKEEASNTPSLESAMTPSLDMSVCRALFQSIAVQNQKLAQNSQSNSST
The following text describes a protein:
Function:
Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MYSQHELRNKVSLALSSLLRYTFELTPFFELYEADFAYALYAGFELATNRKVVGKFSFQNVHLENEYNILTEIAKDERASKFSPTPIEFTSFPHIDLSACIAYDFGHGAELSTSYAYFRENPAEFVRFCIAICKCIEYLHSKGMVHGEIRLDSFIPISSYDNVYMLTVGSGASYFHNCLQAHNWRKYSEDSESMSRILFISPEQTGRTSYSVGYRTDIYSLGVLFFHYLSDCSPYTGSFVQRIRSILTEPLPDISKSCPKLPHLIFKIIEKMTRKNPDERYTSCSGIVNDLEACLDDIDKGLILNDHVLEKTGRTSLFYLPCSIYGREHEIKLIRKILRNSPRAINHQDKKDLETFNPYYLNAIESESSSQSLSLSQRASEVMPLVILITGCEGIGESSLIQTICDRREGYMAITKFEVSQSIVYSAIVSAVAEFIRQILAEDQLLLNNFFEELKNKLESDLYLLDSVFDLVPEIRSLLQQFSTSSGNTRKTSLLGSNHSSYSDKLGSPTILSTSFSLARPYPEPALVSPSTERPPRSSFSAALMTLLNIIASFKKVTMVIENIHLADESSLIILQKIVYSDLPLTLMITCDKENDHVINRFRLANDRIHEIELKPLSFNAVNSYVQATLHRTDDGLARFSSYVYHISKGVPLLVRNVLLSIYENKIIYFDWKKNRWEVNYDEMYTLDNDYSEPDAFMTAKKKISKLNDSSRAILGWASLLGPSFSFATVKKLCKDTDNIELNVEALQSALREGIIYATSSDDTYTFSRSIYVKAMRDLLNEAKIQIMHACLIDVCLKNRDRYNIFDIAFHINAAFDFVKGDKRSVEYCHYLHLAAEEALKIGANQEALDLYNRCIKMIPHEIPEESDDSYIRCQLIGMYVGCAEAYWVNDNFDTASEMLKLAEEKACNNSEVFPARFLYSRILFEGVHIEECTQYVLSCLKPLGYELKRHSLEDSKSIISALIPRIIDKITKSSEESQSSTDDDDRRIFEILSFLYVGSVATSYFSETAEMAIDFGIAQVEFFLSTVVNSFSAFALVYFAILANSLLEPSEDILFIGNYGEKLNREAENPIIFSRTEYLYVQSLGFIDSTTKERRLTIDYLDRNCVTCSDKHVIISLLLVSSWEKFLTSNNYSNYLADFETTHAQIMEMKPWVGDTSLITQLKRFLMCLQDNIKLDLIKSKSFLSDHNIQLSSPAAQESAKLAFSLHGWINSWYLLALVMHGEWDMAISYGENFKREFKNALLTSSRVFGIFMFTWSLVNKMLICPEFTKQKKYYEQYKENLGFFDSLCIGDNECITRVYFLLLKACGLIMNGLNFEASVMLEEVISLTEKLELFLLQAFAFETVGSIFVSMELYTSATQYLEEAIRNYAALGVKQKARHLRDKFGDLLVSNNLQVSIDEATQTDFPLVFSPERSSIDINASSMRSEKASFEIPFPEEQIDDDVSPVAQDSSLEELLISLDIIDLTSVMRSCQTIASEIELTGLLSTMTQRMLEDSSANAAVIAIRDDVGFKIAAYRTGELNEVFAPPMPITEDQTYVPSRVINYVVHTQKALFSNNINHEFDLQQERWNIENHMGRSVIAIPLYQKKEVFAILYLQGPPSAFHSRHMSVLSILGAQASFAIVNISLFHKVKEATNVNTIIIKAQREALNLVQKSEAKYRSFVDTMPCLLSKLEFDEELRIELFGSFWKEYCGELNINDPNTWKEYVHLDDHLKLQDFLLSHLHNPLPFELEIRIKRKDGVYRWNLTRCTPTTNEKNRTSFLCATIDIDDQKKARATALELARLRSNFLANISHELRTPFSGFYGMLSLLDDTNLDSEQRDIVSAARISCEMLLRVINDLLNFSKLEAGKVTLESDLEFSLESVVCDCMQSVYSACAEKGINLSYNVSPDIPFFTAGDGMKIGQMLKSILDNSVKTVNNGFIRVRAFLAGSSKKNDRDQLQIAFIVEDTREESNAIFLANMINSLNRGCNDYLPMDLSGTALGMSTCLQLCKIMGGSVSVEVSQNNPTFKICYDLKIHELGKERYDIIATPLFQNLTEFNDLIKSKVAIRVSKTSTEYDNITTYLQAARKVLHVFKGLQDLASIFDLSPDSALLRCSVVVVDVYSMDDVKAVEKILKSYPDVHVIYLCCDPSRLNIEQELQKPSGRSFACKKRWGFLQMPCTRENFLKVTLQVFKSNEDTCNFYSYVNEYGESPKPDDDMDRLNKCVGSKILIAEDNPIVRMTLKKQLEHLGMDVDAAEDGKETLQIFESHPDNYYQVCFVDYHMPVYDGLEVTRRMRKIERKHGCAPLPIFALTADMQPTMETQFQEVGITHYLSKPFKKETLIKMLLQYLVNGTDGNANTS
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDNVFGAGGPDQWFRSLPIITRTWLGSVLLITALANLDVLKWSELDLRQWQDVVRGPSGKMEAWRLITCFLYAGKFGWNALIGLHMMTQMSNRYETMSPICTRRMNLPPPYNGNNNTSPYYPRGESADYAFALLFGMVGILLSQFLLFPYLPYSLTQGQHYIFFHRHLTFYVVYIWSKHYPLHRVNLFGVAMAAAYLPYAYLLMGYALNNGQVLPIDMLHGMFIGHVYYYLACVVPEVLRGRLVVIATPEILVGLFHWIEGRGVGGGGIDVGGGGVGGDEDNQMLVNVDDVIGG
The following text describes a protein:
Function:
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle.
Sequence:
MSRSLRTRPMTLYAQDGQQPLIPPVGAATATNSSSSSSSYPNKASYARQQTSSSNSQYDAPTLASSSGGGALLKKSKKKASEVGSNLKKRLSMRYAEPTQLGPGGFSAVPAVPSLPRMPEIHIDDRPHRDIDDERYLTAIRETSNDATYDPDEKELNAIRKSSDTQRTRTDVFEGDPAVDLQLLSQSDFDPQAYLRAKLSHHSESSLRQFKSSLAAVKQAANDDLKRQVFKNYSEFITISKEIATLENDMLELKELLSEWKQLPQALELDDSSSAASFSDAFPRSRASGKANRNSTIDLQQIYRAQITSLWEGIEGSQKFLPYVPGRHLIAEASSFTELNAATYKPQQSVALFLLDDLLLIATRKKRQMSSKVRLVAERCFSLAEIVVIDLKDGGDLTNAIKIKRARETHVYRTDRAEDKRALLNAFRRVAEELAKKRRNESYGAGAEGDARKRESTLLSSPYHAPQSYASLGGRSMDDGGLLTSVSEAGDGDAMQVGGGMMAAAAASAASERKDPGRWNNDFADELSVCIALREWDQAVTLIEKGRAVLSTYTSTNDASWRDLSAKLTSLTSELVSAISLDFVRQHLKKSLVTRNASYLLRLDQGEKARQLFLDARTESLKKRTRQIKFEGDTGLYISELAMVHFALIKNTSEWYMAAFKDGSMASGFVEWASERVEEYAVLFRRQVFGVQEQQDEAGTTNAEMVSEMREISLRLATQLNEVGLDFTFLLDRLLQPEPRTMADKHEQEEAEAGESDASVPTLVLTRSSRIGIEGELPKHQMDRQKPKLQGDTTLAQELRRQSMLHLQS
The following text describes a protein:
Function:
Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling. Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms.
Subcellular Localization:
Secreted.
Sequence:
MAVYAHCYLILALLCGPVWPVGPPALLSENEVPLRPSVLLSRGKLTPIRLPKDQLRRLYFTLQKGSPAFSVAVSPCDVPIEWSLTVRMLQSKPATPLHWGEKKSMAEVWWRSSGAEKLLHTYKGNAMDTYSIPPHTQASFYILKLRSVEQDTRISVYLQDGGGSLEAFPQLPPDPRIRIVGLGMTSVTLSWSPSPSALGHGQQRYHYCVLANRRHNYKSMCAVQEAMRKEKMKMGGKQKAAPRPFLKQEWWNFPKSGQRSSSPLQSESLAVLHVCTGTETVYTVSELSPDTQYYFDVFVVDQLNGTSVAYTGTFAHTHQEPRPPVQPLGEGELRWVTVRGGGRPGEHLSFRPRGWQQSALLTLQKCGAGKVRATITSKADQLASQELSEEVTQIWVQGKPTYVIHLETAPPGGPAVSGQWGTAVKIQASSAYHRQAAPLLPASLQIKSFNKLRSCHSVTLAWLGTEERSLYCVYRHKLEQGEGGDTGRCIGPESRSDVEKVLCKYFQELNPRRAVTTATIGGLEPGMAYLFDVYLMRPWGIPVKYLSKVVRTRREC
The following text describes a protein:
Function:
Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT.
Subcellular Localization:
Nucleus.
Sequence:
MSMPTPQYRLQAIRAHDVYEPAEDTFLLIDAIEKDIKEIRSRDPKLVLEIGCGSGVVSTFVNQALGGNVTSVATDLNPHALDVTLETAKLNDIKIDVVRTDLFAGLENLLGKVDVLLFNPPYVPTDEEPKSNIELTYAGGRTGRSTLDRLLPRVPELLSPRGVFYLVALHSNDIPALLKEHSEQMTVSVSMERRCGIEHLYILKFVMKENNVKAAPLAEIE
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MQPKILALLATLLLCFVASVAGQDAAAPAAIKAHASHILVDTEAEADELNAQLAEASNLFLTFAQLAKEHSKCPSSRKGGDLGTFGRGQMVPEFDKVAFEGEIGVVHKVQTQFGWHLLLISRRLDGTEEPDKFRGLKETLLKIMPFLGPIILIGIMALGARGTKGGPRAHAYHILVKSEEEADKLFKEVDAAEDKKTKLSELAQTHSTCPSGKKGGDLGMFGRGEMVPQFDKVVFEEEVGKLTKVQTQFGWHVLLCVERLGDKKSK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Mitochondrion.
Sequence:
MLPRTASATRTPHLNRLVSAGSRRVLPRCSSSLGIRGSLAATPRLLSTITTQQPSPLKRQPAPRATVGFERHLATVLDEPAQTATTPLYELRSFSPQAPLTVRDHTKVYAKQRVNYHGIPGDVNEMFLVFEACLQVGRLERAAQVLKRLANLDVVPPADYLDLFNQYLDAKVSQLLQEPDVDKADDIHKAFETMVSDGRELPVGGETVALLLKASLTSTDPETMQRYVTRYLSLLPTQIALETVFNTEILTYEELTKVAELCPKYNMPDNVDPDTFAQQQQQQQQQQQQQQEQQQQQDTSIDQSEVSIEPLLTSSEPSAIPEVLGTPQKGFGLQFVKRTVSMFKDIPDGFDISTLPMSQQREIQSKLEKDCVDASLARWREENESLQKMGLNTSLDTPSLNSRLYQWQKDLETRLRTMLVEVEKSEMVSKKNKDDLDRCIYGPFIRQSNPERLAAVTIISTLSSLAMGGAHKGSTIASLITHIAKFAEEDIRVQKAEALISKRNLRKAKSKQHNPRSVLRFKNSTASAGSSDMADSNNVAVEMDDEAWTTTIRTKVGAALLSALLDTAKITLVREDPVTKTLITQNQPAFSHVMQLRKGKKIGTIIPNKAVVELLVREPVPDFLARHLPMVTPPDPWVSFEKGAYLETKTPVLRLKNGEREQRLYTEAAIARGDMDQVFKGLDVLGKTGWKINSPVFKVMLDVWNSGKQVANIPPLDPIFDLPPEPASTEDPTVKRAWLKEIKVIENERSGLHSQRCFMNFQLEIARAYRDQTFYFPHNVDFRGRAYPIPPYLNHMGADHVRGLMLFAKGKPLGESGLRWLKVHLANVYGFDKASLQERQDFADENIENIRDSVNNPLNGNQWWLQAEDPWQCLATCFELAAALELEDPTKYVSHLPIHQDGTCNGLQHYAALGGDTWGAQQVNLVPGDRPADVYSAVAKLVIKGIEDDLAKDNEFAKAMHGKITRKVVKQTVMTNVYGVTYVGARKQVLKQIEAAYPNITAESGIEAALLASYVTQHIFRAMSTMFKGAHDIQNWLGEIGGRVCRALTPEQLDEFERSERSPHGDGTASGENITLAGNPRKSSAHKNDEILNNFQSTIIWTTPLRMPVVQPYRKHGTKTVSTCMQDLVMTIPERSDPVNRRKQLQAFPPNFIHSLDASHMILSALHCDELGLTFAAVHDSFWTHASDIDSMNAVLRDAFIRIHSEDVIGRLAAEFQARYKNSLYLAKIETGTKVAQEIQRWRVRNKLGPRKELLLEKERQELLRSSNPEDVERGKKMISPASLYELYSSAEDLTVPEDLKEVTIGNLAGVEETKVRRGREMDEEGEVDGSEEAVEHEDGMHEDEMLADEPRDMDGNSGLDELSELRNTNHFALSQKRAKASIASGGKQKHYLDIWLPLVFPPIPEKGDFDVRSLKDSTYFFS
The following text describes a protein:
Function:
Inhibits bacterial protein biosynthesis by binding to ribosomes. Specifically, binds to the complex of 23S rRNA and ribosomal protein L11 (RPLK) in the 50S ribosomal subunit. While allowing a weak binding of elongation factor G (EF-G) to the ribosome and subsequent GTP-hydrolysis, probably impairs conformational changes in both the ribosome and EF-G which are necessary for translocation. In vitro, inhibits Gram-positive bacteria S.aureus strain 209P (MIC=0.0009 ug/ml), S.aureus strain 133 (MIC=0.0019 ug/ml), S.aureus strain B3 (MIC=0.003 ug/ml), S.aureus strain Hb (MIC=0.003 ug/ml), M.citreus strain ATCC 8411 (MIC=0.0038 ug/ml), M.lysodeikticus strain ATCC 4698 (MIC=0.003 ug/ml), S.lutea strain ATCC 9341 (MIC=0.0011 ug/ml), S.faecalis strain ATCC 9790 (MIC=0.0007 ug/ml), S.viridans (MIC=0.0065 ug/ml), S.pyogenes hemolyticus strain Dig7 (MIC=0.00028 ug/ml), D.pneumoniae strain Til (MIC=0.00015 ug/ml), N.catrrhalis (MIC=0.0017 ug/ml), L.casei strain ATCC 6633 (MIC=0.003 ug/ml), B.cereus strain ATCC 6630 (MIC=0.0071 ug/ml) and various isolates of L.monocytogenes. In vitro, inhibits Gram-negative bacterium P.multocida strain A125 (MIC=0.0024 ug/ml) but not M.smegmatis strain ATCC 6630, S.typhimurium, A.aerogenes strain ATCC 8308, P.vulgaris, K.pneumoniae strain ATCC 10031, S.marcescens strain A476, P.aeruginosa strain Bass or B.bronchiseptica strain CN387. Does not inhibit Gram-negative bacterium E.coli strain ATCC 9637 but does inhibit purified ribosomes from E.coli. In vivo, has no systemic effect in mice infected with staphylococci or streptococci when applied orally or subcutaneously. Has a local effect in mice infected subcutaneously or intraperitoneally with staphylococci when applied immediately afterwards. Is not toxic to mice.
Miscellaneous:
MISCELLANEOUS: The mature peptide is identical to multhiomycin from S.antibioticus strain 8446CC1 (PMID 681244); MISCELLANEOUS: Used as an antibiotic growth promotant in poultry and pig farming in parts of Asia.
Sequence:
MDAAHLSDLDIDALEISEFLDESRLEDSEVVAKVMSASCTTCECCCSCSS
The following text describes a protein:
Function:
Could act as an H1-type linker histone.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MPPKKTETKAADASAAAAPAPAAAPTSAPKTKSPSTHASYLDMITDAIVALKDRAGSSRQALKKYVRANNTLGNVTDNMFDSLFNKALKNGVDKGVFEQPKGPSGGTKLAKKVAKPAPKKAAPKKETKEKKPAAAKKEGAAKKETKEKKAPAAKKAAAPKKAAAPKKEVKEKKAAAPKKKAAAPAVADKETVLTKTKSGRVAKSTAKPAAAKKAAAPKKAAASKKAEKAEPAAEKA
The following text describes a protein:
Function:
Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDPEKFYSDAIDYWNGVQPTVDGMLGGLGTGRIPQTDVVGSRTFLNRLNYRIGKIENLVAADCGAGIGRVTENVLLKIASHVDLVEPVENFISTAKKQLATKPCSFINVGLQNWTPEKNRYGLIWNQWCLSHLTDEDLIAYLSRCCEAIQEKGVICVKENVSSFEDTFDPIDSSVTRCEQSLKSLFKKANLVVVAETLQHGFPEELFPVKMYALVPHSS
The following text describes a protein:
Function:
Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Vacuole membrane.
Sequence:
MRKSFARRSDTMRRAPPRWWRSDLRAVREIILGNWINLLLLITPVGLAAGYLKWSAGYVFTLNFLSLVPLALVLGDVTEDLALRYGSVIGGLINATFGNIVEIILSIAALLNGLYGVVAASLLGSILSNLLLVMGCSFFFGGLWNKTQRFNATGNQASGSLLFLAALGFLIPTGAGLLFGGGVEHDHEALVLGISRGTAVVLLLCYACYLGFQLYTHTDLFEDNGGHEEIGSDGLPADAEEPMLSLVASVGLLTVITLVVAVASEFLTSSLEEFSKTSGLGEAFLGTIVLPIAGNACEHMTAVIVATKNKMDLSMGVAVGSSIQVALFAVPFAVVVGWATGHPFTLFFDPFSALALMLSVAQANFVTAGATSHWLLGVQLIALYVLISIAYFFK
The following text describes a protein:
Function:
Involved in terpene biosynthesis in roots. Possesses diterpene (C20) synthase activity in vitro. Does not seem to be involved in sesquiterpene (C15) biosynthesis.
Subcellular Localization:
Cytoplasm.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MEATSVFRPKLGSQFSLPSTTNLFPLRKLYGFPLTSFPGKPIKRIRLKATNTLTFDDKERTRKFKKLPLSEWTHYFHSIPLDISEMDALKEEIDELKPKVKNTFMSSQGSDSTKTKILMIYLFVSLGLAYHFEEEIYETLKEGFENIEKIMAGEEDLYTVSIIFWVFRRYGHYISSDVFQRFKGSNGSFKESLIGDAKGMLSLYEAAHLATTKDYILDEALIFTSSHLETLVATGTCPPHLLARIRNALSICQHWNFEVLVPLDFIPFYEQEKDHDEMLLKFAKLSFKYLKLIYLQDLKILTKWYKKLDFPSKFPPYFKDRCVENYFFVLPVFFEPQLSSARMLLTKGFILLGIQDDTFDRYASISEAESLGNSLKRWAPDHSMDKQPEYLKSVLKVILDTFQEFEKELSPEGRSYSVKYTIEEFQASSKANVELAKWAQVSHVPSFEKYMEVGQMEITACVTVAYILMSMGKTGTKEAFEWLKSRPKLVQSLCTKGRLMNDIAGFEDDMSRGYVVNAVNCYMKQYGVTEKEAFKELRKMVVNTHKTLNEEFLTTTCVSHYVLRETMDFARMIIVTYNGYEGFTRPDEGKIEEYMTSLFVDHTLKML
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MRRSQGRRSSNTLPIRTLSGVVAKQPVANLSTSMASSAHKRSSSIPRPSASSADVLVVFQMKPMYGQRQDQSLAVGVTPSKSGPLRFTGATPQMGGTTPQSRGNMTLTGAAKPYLKETRNLSDKNCVLEMAKNVAQFLNGSGFPESVTHKEIQKIDKQSFMKYFNYIYQFIDHNYQLAPRFNEDELIKNMKDLGYCGTLAKSALVSIGALHSTSQIAGLLSWLCDLIRVIMSEQDDESLEKAELVIMTQSYNAWCMDVNFDLSDEFRRFYMEKHQVEEGRAEMLERQIKAITEEYKAIEKKSSQTEELRAEAKKEEQRLEEISAKEVQMQQRCKELQNEERHLVQRLEEIKEKTALAQKDIAALQIAAKNCKVSADEARRIKSAIVANKRDYAAASEQREQVAKLVEKREMQLANIAAQDIKFDRELNVDLMDMGMTIPAGMDPKEALKNFLEAKISNLSDIESRCIALTERKERILAEISQFKMELKHTELLKSRLEEKLQSVKADRDEMERLYLSQLAELESLSAAPRSDPLQMRQQYELETLQQKFAEQKAQMDKQEKELQSTMAKHAQELKDGETEIQKIEAMAADYFVRLSDGFRQVLKQAENNPVSQELINALIPKPNFK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, UBC28 and UBC29 in vitro.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MHYTRISPALVPSLSPTAAAESSGGGTMIATVFMALLLPCVGMCIVFLIYLFLLWCSTRRRIERLRFAEPVKPVTGKGLSVLELEKIPKLTGRELAVIARSTECAVCLEDIESGQSTRLVPGCNHGFHQLCADTWLSNHTVCPVCRAELAPNLPQCNENQSPC
The following text describes a protein:
Function:
May be a transcription factor.
Sequence:
MFYSRQTNVNFTSALSSSPRRLVDNFCICEGYSVPRCLMYEIYVETCGQNAQNQVNPATFGKLVHLVFPDLGTRRLGTRGSARYHYDGICIKKSSFFYAQYCYLLGEKRYHSGDIIAFEKSPNYNSIIQQKGTCENHSPIKTDPVGSPLSEFRRCPFWEQELAKKYSYKMMAFLADDYYNYCQDILQNVRNQEFERVEDLLTSFWKSLQQDTVMLMSLPDVCQLFKYYDVQLYKGIEDILLHDFLEDVSIQYLKSVRLFSKKFKLWLLNALEGFPALVQISKLKEVTVFVKRLRRKTYLSNMAKTMRMLLENNRRVHILKSDLHAIIDQGTLDLSKKALPSTPSSSVDLEMHTEMKCLSSLIALLGTSTDLSVFLNCLYSNLQTFVLQPSRNKEEFVQLAASFQLRWNFLLTAVSKAMTLCHRESFGSWHLFHLLLLEFVTHILQSRIEEEEEDDDVGNLKEMLPDDQSLVQPDQAPFHPPDSSPTQEYDSPSVDPHRVTLKHMGQSQYPVGVSSVVLRVLGFLVDTDTGNKLIQVLLEDKATESTVKLSLPVGQEALVTLKDGQKFVIHISDVPPKL
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Repressor of flowering.
Miscellaneous:
MISCELLANEOUS: 'Schnarchzapfen' means 'snoring cone' in German.
Subcellular Localization:
Nucleus.
Sequence:
MLDLNLGILSTHNEDEDCKVPTSIFIQEEDSINPSNDNLSLITFGILKRNVEILPPPPPPPPPPPPSENELSGPGNEWLDLSSMQRNKQETLVMKKKSRRGPRSRSSHYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAYTAARAYDRAAIRFRGLQADINFIVDDYKQDIEKMKNLSKEEFVQSLRRASASLARGGSKYKNTHMRNDHIHLFQNRGLNAAAAKCNEIRKMEGDIKLGAHSKGNEHNDLELSLGISSSSKVRILEPADYYMGLNRSVTSLHGKPLPGYLPITEIKPLKTVVASSGFPFITMINPSSLSLSCFDP
The following text describes a protein:
Function:
Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters.
Subcellular Localization:
Cytoplasm.
Sequence:
MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL
The following text describes a protein:
Function:
Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEISNRLQILLIDCYDSYTFNLYDLLYKASENACVIVVHWDKMSPDLWEDILQFDAIVVGPGPGHPAEYSSILNRIWQLNIPVMGICLGFQSLALYHGATIERMPNLPWHGRVSSVTTSKTFIFDGISAVKGMRYHSLYANKIPIDSLQILAQSDEDNIVMSIKATKFPHFGILYHPESVGSSKSLKIFKNFLSLADTPNIQCVNSFSKSANGFSHNLNRYDISPAAFILKSGSPSLQIHSVEIPWVEPLALADCIQKSGNPICFLDSAKKPGRYSILGILTGPLARIIHYEKATNTTEIRICKDNSFVRINNDLWSTVADFMNQHKAIKPDTNLPFYGGIMGIIGYECSDLSTKSVSNASFPLDFQQTTVDAELAFVDRSFVFDLEIKKLFVQTLTPLNETCSEWWGELLASTCNTKLDNLSCLHSFDGKQNFGLVQSFPKKEVYCESVKACQEHLLAGDSYEMCLTDTTFVSAPPELSDFEMYMRARSLNPATFAGFVRLNHFTLLCCSPERFLQFRDDRCLFSPIKGTLKREGHMSLEEARKKLLNEKDMGELNMIIDLIRNDLHQLAKKNSVHVPELYSVEEHSNVYSLLSNIYGRIESPITAWDVLSKSFPPGSMTGAPKLRSVRMLEPLEQHGRGIYSGTLGYWDVTGSAEFNVIIRSAFKYKADDYWRIGAGGAVTILSSPEGEYEEMVLKANSILPAFVNLKNKKRSCK
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MSNPEQTLGVTPPISTTLPTDAEKRQTEALLKELRAQGTFESQAETDKRWAVLADLQRITDEFVKRAAQEKEPHNAILIRDARGRIFTYGSFRLGVYGPGSDIDTLVVVPKYVTVKQYFDIFPNLLVEMAPPGAITDLTPVPEAFVPIIKFEYSGISIDLIFCSIQSLRQLPDDKDWNLNSNNLLRGLSENEVRSLNGTRVTDEILALVPEEKTFKLALRAIKLWAQRRAIYANIMGYPGGVAWAMLVARVCQLYPKATSAVIVRKFFTIMLNWPWPLPVLLKNIEYNQSITRVAVWNPKIYPSDRNHKMPIITPSYPSMCATHNVGRSSMAVIQQELERGVQISEEIMLGKRPWKDLFEKHTFFTNGFKFYLTVISSGRTKEAQNTWSGFVESRVRVLVQKLELHPSIALARPFNKGYDRVHRCKTDAQVEEIQTGNLTYMVKPTDIAANGSAKNDSKVEVKAEIKTEDGVAREPTVPAVKEEPNDVVHLGTVPLKPEDNSVKPEANDYDEDKVKLEDIPEKEPELEIYTTNHYIGLQLVEGAKSLDLSREVDDFKAMCTSNDIFKAELMGLTIQHVRNFDLPDDVFEPGETKPVRPVKKKKRMAEGEHANGPMAKRQQMATAPPTIKSEH
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MPNLVADLEGLQAGPRPRSVPRQGDVPATDGGAPWRVFELLVYYCSTFMEMIPLSFMLGFYVTFTATRWWNQYMAIPWPDRLMNVLMMYVPGQDDGSRMLRRTLMRYLNLSLILVLRSISKAVKRRFPTKDHLIEAAFLPLLESRQEFNDFRAKCGLLWSYDWISIPLVYTQVVTMATYSFFAAAVFGRQYIHSPDPIIDSRHHFDFYVPVFTVIQYFLYMGLLKVAEQLINPFGDDDEDFELNWIIDRHFKVSYLGVDTLDGPPPPLVKDSYFYKMDYQLPYTAASVSYKKKTYRGSVAYMHVPQKERGMVVPEMSEEDDEDSPRDGGSGGEDDDGRHGLSKRSSSSLWTLMHRRSTSPPNDNVESGLAQDSKLHVYFKGSSPSGSQEDSEDANGLSDGSQQKHLLQAHEERRSDRQGPEPSPLHGQRSFLRELFSSKPAMRVQAWTGADGDYASPAKRPRKHHHRTKVSFCAETSGRPRFDKSSLRLKSRFAYCLVVFAQRASNEMKLV
The following text describes a protein:
Function:
Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 and hmr-1 lateral localization. Maintains cell polarity by correctly positioning adherens junction protein components including ajm-1 and hmp-1 at discrete subapical positions. Plays a role in the correct localization of the dlg-1-ajm-1 complex, polarity protein par-3, and actin microfilament to the apical junction of spermatheca cells, and is required for ovulation. Regulates the establishment of newly-formed epithelia in conjunction with dlg-1. Required in the epidermis during larval development. Plays a role in cellular junction integrity and in the directed outgrowth of seam cells, towards neighboring seam cells, during larval development; probably acts by promoting the assembly and stability of dlg-1 at apical junctions.
Subcellular Localization:
Basolateral cell membrane; Peripheral membrane protein. Note=Basolateral membrane of epithelial cells.
Sequence:
MPAFFCLPMACQRQVDSIDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVLPAEIGNLTQLIELNLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITILSLNETSLTLLPSNIGSLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEIGKLTSLREFYVDINSLTSLPDSISGCRMLDQLDVSENQIIRLPENLGRMPNLTDLNISINEIIELPSSFGELKRLQMLKADRNSLHNLTSEIGKCQSLTELYLGQNFLTDLPDTIGDLRQLTTLNVDCNNLSDIPDTIGNCKSLTVLSLRQNILTELPMTIGKCENLTVLDVASNKLPHLPFTVKVLYKLQALWLSENQTQSILKLSETRDDRKGIKVVTCYLLPQVDAIDGEGRSGSAQHNTDRGAFLGGPKVHFHDQADTTFEENKEAEIHLGNFERHNTPHPKTPKHKKGSIDGHMLPHEIDQPRQLSLVSNHRTSTSSFGESSNSINRDLADIRAQNGVREATLSPEREERMATSLSSLSNLAAGTQNMHTIRIQKDDTGKLGLSFAGGTSNDPAPNSNGDSGLFVTKVTPGSAAYRCGLREGDKLIRANDVNMINASQDNAMEAIKKRETVELVVLRRSPSPVSRTSEPSLNGSSHQLNHFDAGSPDSTMFVTSSTPVYAS