lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.
Subcellular Localization:
Secreted. Note=Localizes at the tip of cochlear outer hair cells and to the tectorial membrane.
Sequence:
MKMPLTWYSWFLLSAWILNTGAEISITPEPAQPAEGDNVTLVVHGLSGELLAYNWYAGPTLSLTFLVASYIVSTGDETPGPAHTGREAVRPDGSLDIHGALPGHTGTYILQTLNRQFQTEVGYGHMQVYEILAPPTVMANDTALVERRDTLRLVCSSPSPAEVRWFFNGDALPVAVRLGMSPDGRMLTRHGVRREEAGAYQCEVWNPVSVSRSEPLNLTVYFGPERVAILQDSTTRTGCTIKVDFNMSLTLWCVARSCPEPEYVWAFNGKALKNGQDHLNISSMTAAHEGTYTCIAKNSKTLLSGSASVVVKLSAAAVAMMIVPVPTKPTEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGNWIAGPAHTGREVGFANCSLLVQKLNLTDAGRYTLKTVTLQGKTDTLEVELQVAPLE
The following text describes a protein:
Function:
transcription factor which binds to a weak acid response element (WARE) to mediate stress induction of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively.
Miscellaneous:
MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDTQIAITGVAVGKEINNDNSKTDQKVSLPKADVPCIDKATQTIIEGCSKDDPRLSYPTKLETTEKGKTKRNSFACVCCHSLKQKCEPSDVNDIYRKPCRRCLKHKKLCKFDLSKRTRKRKPRSRSPTPFESPMVNVSTKSKGPTDSEESSLKDGTSYLASFPSDPNAKQFPNSRTVLPGLQQSLSDLWSTLSQPPSYGAREAETTSTGEITTNNHTKSNGSVPTNPAVLASNDEHTNISDAPVIYSTYNSPVPISSAPTSINSEALFKHRPKIVGDEETQNVKVKRQKKSYSRHMTRSFRKQLQSLIISQKGKIRDISMKLDTWSKQWNDLVEKSMFLPTIADPVSVGIISHEEATLRLHLYKTEISYLSKLPFIKVEENVSVDELRKKKPILFSVIMSCVSIVLTPKQTTRGTIMKLDSFVLNLITNQIFKANNKSIEIIESLSTLCLWYNFFEWSSKTRYHIFNYICCCLTRDLGPTYVNRSFGMFSDEDPKRFKSPLELYSNGASLTLLVYISALNISIFLRQSIQARWSHVTEKACEDLVKETKKSRHYDNDKLLLDSADDPILVQFAKMNHVLENIHTHLHERDLNDDEFDDPIFTKKYLNKLMEKYHKQLQEIFTKLDRNRPRVIAFYYSVEAYLYQYKLAVFIGEMSHTINEKVELPREIMDDFVKCYHCCKSALEEFSKLEPILITSLPLFHTSRIIYTVGMLLLKLRYSVVAIPSFHDLMPLTDDAIALVIGVNNLLEKTSELYPFNNSLYKFRYVIALFCQTYANKVIDVADRYNAEREKLKEKQVIDEVSNGHDGTKPINAYVTESQKMPTEEDPIIDNNTNQNITAVPDEMLPVYSRVRDDTAAMNLNINSTSYMNESPHEHRESMTGTTLLPPPFISNDVTNSADSTNIKPSPSSSVDNLNDYLTDINSLAWGVNSLNDEFWTDLFMNDI
The following text describes a protein:
Function:
Transcriptional corepressor. Negative regulator of jasmonate responses.
Subcellular Localization:
Nucleus.
Sequence:
MSSLSRELVFLILQFLEEEKFKESVHKLEKESGFFFNMKYFEEKVQAGEWEEVEKYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDRQDKAKGVEILVNDLKVFSTFNEELYKEITQLLTLGNFRENEQLSKYGDTKTARSIMWIELKKLIEANPLFRDKFAFPSLKSSRLRTLINQSLNWQHQLCKNPRPNPDIKTLFADHACTPPNGPLAPAPVNLPVAAPAKPLAYTTLGVHGPFPPTAAAANAGALAGWMTNASAPSPVQVAVVTASSIPVPQNQVSILKRPRTPPTAPGMVDYQSPDEQLMKRLRPAQSVEEVTYPASRQQASWSLDDLPRTVALNLHQGSAVTSMDFHPSHHTLLLVGSANGEVTLWELGLRERLVSKPFKIWEMTAYPLQFQASLVKDAPISVNRVTWSPDGNLVGVAFNKHLIHLYAYTGSNDLRQQLEIDAHVGGVNDLAFAHPNKQLCVVTCGDDKLIKVWDLGGQKLFNFEGHEAPVYSICPHHKENIQFIFSTAIDGKIKAWLYDNLGSRVDYDAPGRWCTTMLYSADGSRLFSCGTSKEGDSFLVEWNESEGAIKRHYAGFRKKSTMGVVQFDTTQNHFLAAGEDNQIKFWDMDNPNVLISTDADGGLPSLPRLRFNKEGYLLAVTTADNGFKILANATGLRSLRPVETPAFEALKSPIESAAIKVSGTSGVTNVIPVNCKVERSSPVRPSPILNGVDNLNRSMDKPRTVDDVIDKSKPWQLAEIVDPGDCRLVTLPDSTNTSSKVVRLLYTNSGVGILALGSKGIQKLWKWTRNDQNVTGKATASVVPQLWQPNSGLLMANDVSGVNLEEAVPCIALSKNDSYVMSAAGGKVSLFNMMTFKVMTTFMSPPPASTFLAFHPHDNNIIAIGMEDSAIHIYNVRVDEVKSKLKGHQKRITGLAFSTNLNILVSSGADAQLCVWSIDTWEKRKSLTIQIPAGNAPNGDTRVQFHSDQTRLLVVHETQLAIYDASKMEPVRQWVPQDALSAPLSYAAYSCNSQLIYASFRDGNIGVFDADSLRLRCRIASSAYLSQATMNGSQSVYPLVVAAHPQEANQLAIGLTDGSVKVMEPTESEGKWGSTPPADNGTLNGRTTSSSTTSNHTPDQLQR
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MQRPEAWPRPHPGEGASAAQAGGAAPPTRATEQRFQEPSLYTIKAVFILDNDGRRLLAKYYDDTFPSMKEQMVFEKNVFNKTSRTESEIAFLAGMTIVYKSSIDIFLYVVGSSSENENVEKRWLLENMDGAFLVLDEIVDGGVILESDPQQVIQKVNFRTDDSGLTEQSVAQVLQSAKEQIKWSLLK
The following text describes a protein:
Function:
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Sequence:
MNKIIKGDRVVVIAGKDKGKQGQVVRVLGDKVVVEGVNVVKRHQKPNPMRGIEGGIITKEMPLDISNIAILNPETNKADRVGIKLIENEGKVKRVRFFKSNGSIIGA
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Might be a pH sensor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLKPATPLTILLLIAFVLLLLSVISTPIVKSIPLATFDNVEYGVFGYCKAGTCTAIHIGYTTEEIENTGSTDSDFNLPSDARRSLSSILIVHPIAAFLTLICLCLAAAAHLHAPSHSPRYLLALLILLLPTLLVSLLAFLVDILLFVPHLSWGGWIVLAATIILVTCGVVTCAMRRTLVSRKARKRRIAENAEMSGQNYYNRQNAAAAALNESKPIAPEAKETFVAATQSSESGPTFATFRTNTRSSDDDRTPLNNHSDPSAQDAGYQSRIPGDPVPYNAPRDDFGNPLPPGAYNSAPRMRTPGPPGPPPPDSRVRDQYSDPRRGPPTGFAPRGRGGYPPRGGYGRGGPYGGPYGPNSRAPLTGRGGYMGPMRGGPAGPMARGGYRPQPAAGGYGNARAMGEDEYGYRGPSSRQRTPGPMAAPAAPGPAGQAIEMMPQPRHEPDAQDEVPEQQQLHAISIDNQHEPVSPTSLYSRTQSYVPPRRNWGPQAYQSSEPNLPYQPNQPRHARSQSGSMYYEDEDPVYTSRNESAVGNSGVPSVLTPGNSAK
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSTGGVLSRAVRGGSYRFLQRLLTFAANSLVLRKLHLNVTGAVTVRLELALASIFLLRDGFRLAFLRMPSLDSNNGGTHLQQLVNVAWLSTTISWAVATLVLAYAAVRDSSEPLGGDEALAGYSTVLAMYCGAAMIEALAEPMFVLAHASVLVSWQVAAQSAAFLVRAAVQYVGVVVLELSLTAYGIAELSYAMTLLVMFGVLFWRRIDRASKEGRGFALTSMRQLLPGKPEGGGDWCHRELMTLLVPLSVQSGVKYLLAEGDKWVLAGFASLQHMGVYGLVSNLGSLVPRIVFLPIEEATKTIFSKLALAQKHKSDNKDDLENKKRGLSDGKTLLLVLLKLMNLVGLVFVCFGTSYAYTLVLLLYGAEKAQQGVGAALAVYCAYIPFLGVNGVCEAVVHAIGDDHELMRLNKLLGVFFAIYAISALVFMQVLDWGTLGLILANCVNMGCRILYCLKFLASYFRQTASTSKTGNDFIDGLAFWRQSLPDRLVVVAFLTSLVVTVTSQQVLLHSESDGSISLMRHMLHVALGAICFGGTVLTLYIKERHLLGVQLAALRGQNKSHDD
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes. Involved in dendrite development of Pukinje cells.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Sequence:
MASILDEYEDSLSRSAVLQTGCPSVGIPHSGYVSAHLEKEVPIFTKQRVDFTPSERITSLVVSCNQLCMSLGKDTLLRIDLGKASEPNRVELGRKDDAKVHKMFLDHTGSHLLVALSSTEVLYMNRNGQKARPLARWKGQLVESVGWNKAMGNESSTGPILVGTAQGQIFEAELSASEGGLFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRGFVIATTRQRLFQFIGRAVEDTEAQGFAGLFAAYTDHPPPFREFPSNLGYSELAFYTPKLRSAPRAFAWMMGDGVLYGSLDCGRPDSLLSEERVWEYPAGVGPGANPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFLEKFGPLRHMVKDSSTGHLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQHRYLESARCYALTQSYFEEIALKFLEARQEEALAEFLQRKLAGLKPTERTQATLLTTWLTELYLSRLGALQGDPDALTLYRDTRECFRTFLSSPRHKEWLFASRASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPALVNYSQGGEAQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGQPASLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVLELYEEAVDLALQVDVDLAKQCADLPEEDEELRKKLWLKIARHVVQEEEDVQTAMACLASCPLLKIEDVLPFFPDFVTIDHFKEAICSSLKAYNHHIQELQREMEEATASAQRIRRDLQELRGRYGTVEPQDKCSTCDFPLLNRPFYLFLCGHMFHADCLLQAVRPGLPAYKQARLEELQRKLGAAPPPTKGSVKAKEAEAGAAAVGPSREQLKADLDELVAAECVYCGELMIRSIDRPFIDPQRYEEEHLSWL
The following text describes a protein:
Function:
Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate. STT4 functions in PKC1 protein kinase pathway.
Miscellaneous:
MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
Sequence:
MRFTRGLKASSSLRAKAIGRLTKLSTGAPNDQNSNGTTLDLITHTLPIFYSTNTSKIYTIPLTLSEWEVLTSLCVAIPTTLDLVETMLKEIIAPYFLETPRQRISDVLSSKFKLEQMRNPIELLTFQLTKFMIQACEQYPVLYENIGGIISTYFERVLKIFTIKQSGLLSLVGFINAFIQFPNSTELTKFTWKKLAKLVLRGSFLNEVDKILNSSATFTNDSIVQYYDAGNELSSAYLLELISRLQVSLISHLLNTSHVGANLSEFLLNQQYQFYKFDQEVADENDDTKCIDDFFFNVRSNKQFFTDMCKISLQFCSESHILDLSTDNRARFSFDTRAHYLQTLCLIPFIEDTESELFESFTNVVSESIDKFFLSDVVTPSLIKAIVASASLLNFFTEKLSLTLIRMFPLLVASPHITTETVNDVAKIFTTGLYPLNEDAIVSTIYSMNNLLAVSEDGSPVPVLRERQLTITSGKNIEKDYFPLRNSSASLDGTGALLGNTTVGQLSSHDVNSGATMTYHASLISNCVAATTTIASYYNTQSITALTISILTQKVNSMSKELDGVILNSLARLAPNTSLTEFSLLLKFFKSRTVIATKIDDSALLKNIIKAKCVISKELLARHFSSDLYFMYLHDLLDSIIASGEVERLEHHRPQTEISRVADQIATYLEPLAALLPVPGDTPLDINKDEVTTNKFRNAWFNFVIHGYHLGGPIVKRNFSFLLTIAYNSPPLASEFPANNKELSLEMNTILRRGSSNENIKQQKQQITEYFNTNIVQYRTTSSSKIMFLAAAVLLETIRCEAGDCSKTLLYFSDPSILSGSIEKCIAVLSVSMIRKYARLIQKGNDAIFNSKMIAQQLNNLLLCLSHREPTLQDAAFHACEIFIRSIPSSLCHHLSLYTLLDMLTALFDSILDSEAHKFEPRYEFKLKHSKTTILVPSSSSWRATTLSRLHKSAKEWVRILLNRSNQDTKILLQSYISDLGEYSRLNSVEFGVSFAMDMAGLILPADKELSRLTYYGPEKPNTISGFISLHSWRSKYLFDTAITSSPEDIKRQIGISTQNIRKNLTLGNKIITKDVTDFLDMATALLILGNGAPASLIYDIVHIPFEVFTSASLKIATNVWLTIITEKPEVAHLLLVEVCYCWMRSIDDNIGLYSRDHDLKGEEYQKMEYSPYDKAGINRDAKNASQAMQPHLHVIKFFASHFEGTLFQSDFLLKIFTKCALYGIKNLYKASLHPFARMIRHELLLFATLVLNASYKQGSKYMGRLSQEITNGALSWFKRPVAWPFGSNELKIKADLSVTRDLFLQLNKLSSLMSRHCGKDYKILNYFLASEIQQIQTWLTPTEKIEGADSNELTSDIVEATFAKDPTLAINLLQRCYSKKAEDVLVGLVAKHALMCVGSPSALDLFIKGSHLSSKKDLHATLYWAPVSPLKSINLFLPEWQGNSFILQFSIYSLESQDVNLAFFYVPQIVQCLRYDKTGYVERLILDTAKISVLFSHQIIWNMLANCYKDDEGIQEDEIKPTLDRIRERMVSSFSQSHRDFYEREFEFFDEVTGISGKLKPYIKKSKAEKKHKIDEEMSKIEVKPDVYLPSNPDGVVIDIDRKSGKPLQSHAKAPFMATFKIKKDVKDPLTGKNKEVEKWQAAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGCGVIDVLPNSVSRDMLGREAVNGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQTPAYLDFEELCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTIRNLRARFQPQKTDHEAALYMKALIRKSYESIFTKGYDEFQRLTNGIPY
The following text describes a protein:
Function:
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMNNKISVKMVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDLNKATKEVAKGNFNTRLSENSWTDEIREMAHSVNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEERREYIHKILISTKRLSSLSGNILQITELENQKILPLEQKYYLDEQIRQTILLFEYEWTKKNIILDINLDNITYIGSKELLAQVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKNRVFEKFYQGDSSHYSDGNGLGLALVKRIIDICEGTIEISSHEAVGTEFTVKLPK
The following text describes a protein:
Function:
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMWQKYAGSRRSMPLGARILFHGVFYAGGFAIVYYLIQKFHSRALYYKLAVEQLQSHPEAQEALGPPLNIHYLKLIDRENFVDIVDAKLKIPVSGSKSEGLLYVHSSRGGPFQRWHLDEVFLELKDGQQIPVFKLSGENGDEVKKE
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MTEANLLTILQELGAIVTNDHIVYTSGRHGSSYVNKDALYPHTAAASMVGAALAGHFATAGVETVAGPTIGGVIMAQWTAHHLSQICGREVLAVYAEEEQHDTGKRRVFRRGYDAHIAGKRVLVVEDVITTGGSVRLVVEAVTAAGGVVVGVGALCNRGGISAADLGIPQLVALTELPLESYPAETCPLCAAGVPVNTRLGKGAAYVRNLTTNPSSPTS
The following text describes a protein:
Function:
Transcriptional activator that controls the onset of premeiotic DNA synthesis by regulating res2 and some other factor(s) in a mei2 independent cascade.
Subcellular Localization:
Nucleus.
Sequence:
MDSDRCLTDEISLNTLSSTFASDNNLRRKENFLKSRYPSKFDLNVSMLTKSDDVGKTPFSIFDSPSNPGFSRSHQMCSDKNKSPFLFDKIRDEPVSVDPVKLIINNRNKRKINRQKSRLQGLYRSDANGLQPLNSENVKMKKSTALSLTSSPLNSWKTDFKTPPKANVVCISLVIEGDGCASLLYEDLNQISNSCPEVAPNRQNALFSDETLTTMFYSGVTEDEGSCNNLLQSSFGDDLDLGMQRSATWAPGYNYPSKFDSIPFASASPKIKAAFPFDPNVYALNTNDGPVTSTDNNCDQLNTRMQAWNNGFNYSNLNGDIQYPAVTPKFFQQEGRALNVSDCNFGNEEIAYGGIPMRVCHSDSTLCDARIAAKQALKGKRQYDTSTSKAELSTPPSKRRHIDDADLVFHSSPLLSRSRFICCYCTKPFLSISKLQEHESSCSHVERLFGFAPNRLYDDGDGFLGSSFCSDW
The following text describes a protein:
Function:
May be involved in the polarity establishment process. Suppresses the lethality of KEX2-GAS1 double null mutant when overexpressed.
Miscellaneous:
MISCELLANEOUS: Present with 1550 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass membrane protein. Note=Localizes primarily to the growing sites, such as an incipient bud site in the cells with emerging buds, a bud tip in small- or medium-budded cells, or a cell periphery in large-budded cells.
Sequence:
MYHTHMHESLISVTSTVSVSDASYAYARLTRRDDSDSSSSSASSTKNSKSAECTGSKQQCQLPTDSSHSTSVTVGVAVAVPVGVIIIVLAVILCIVYRRSKKEAEEDNDPDFEGDSEFLPTMKDYSPGINHLYSSDSQQDFMEKTLQQPPSDPFVGSMHSSKYNVRSATPPAIGRSWYVDPFQLPQESNDSNSLRDFAMRVQEDGLGGYKVAAESRNASQTSLHPDNFSNCTPIRASSRFQESESFRSHGSPIHNNQLSRGSATEGANKQFTFPNEDNDSSSVSEEAEVLNESNESASNDAFEFELDNSSEKTHERNLRFGKDDDNYELQDIREAEHMNDRSSSKSQDDDYYVSLLSPNEEEDIKRMKSIYQVYLDRAKTMKKEEDKADNANDISQEENRVDNIVQNPLPSIKINNNDNIDNNEVPEAKHLVKEALPLNNTNLAEYGPEMAQSQKQYPVQDTLTVNDTEAAPSNRIASSIYSEAIQPLNYQDQYQQQEQSPVYNGHTQYPGNGYSGNPQQQGYTAQFVQNPQWYGVPTPQQQQHNHPQTLETIGELPTPAYLAQSASSHSLTSFKRPNKQQLLQLQTARLNGTALNPVDHPEMFYSPTNDAYYAPQQQGQYMKFNENGAVPSPYQLRQSVVMTNPSDLTAKPSYKPAGSFRSVSATNSRNNSLTTQNNIYLQQQQQQLYNSRVSGILEETDVVQPPSVGGILPHSGSQDDLRKQLGSSHNYTVN
The following text describes a protein:
Function:
Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASVVPFKEKKLLDVKLRELSSWILMRDFIPKGIAGAFQRGYCQYYNKLNMKKGSVAGFSMVLAAYMFFNYDWLKKSLSNFHFKKYEL
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSDNLYDEFGNYIGESLEDEEVTYDQQQQQQEEEEEEDRKPNQQQQQQQYNDDEAHIEETGDNDGGDEMNIDRDNIQISTTSAIVLHEDKQYFPDASDVYKGVEVMVQDEDSQPLSKPIIDPKKNKSFTITEKDYPETSYSKQFLTDLSTYPQFIRNVSLIGQLHHGKTSFMDMLFQQTHEKKWLSSKPMRYTDTRNDEQERLISIKSTPMSLVLPNSKDKSYLINILDTPGHPNFLDEVTASIALSDIAVIIIDALEGVMMQTERLIKHAVAEGLSICVVINKMDRLILELKLPPVDAYFKLKHTIDEVNSILDLCSHGSGSGGSDGNTRGSANEKIKVSPELGNVIFASSEMGWCFSLESFANIYIETYGGGFKSSEFAKRLWGDLYFNESTRMFRKQASGNGEHVRSFVHFILNPIYKIYSTVISEEKPVVEATLRELGIKLSKETYNLDIRPLLRVVLGSFFGGKSNAFVDMLAALPSPIDNARRKATTLYTGPLNGEYGRSLVECDPKGPLLIYITKLLSKPDGKGFDCLGRIMSGSISKGQSIRVLREKYSPDNNEEDMEECECEGVFIGEARYKIEIEKAQAGMWVLLDGVDGPIVKTATITSKKDLSSDEDENRAHIFRPLHFITKSVCKVAIEPINPSELPKMLDGLRKIDKSYPLAITKAEESGEHVILGTGELYLDCILHDLRLMYTEIEIKVDDPVITLTETIVETSSIKCYADTQNKKNRLTMIAEPLENGLADDIENGMVKLDWPKKKRSEYFQSKYDWDVLASNSIWAFGPDINGPNILLNDTLPTEVNRSLLLSISDSVVRGFQWATKEGPLVDEPIRNVKFKLLDATIASEPIQRSSGHIVPAARSVTHSSFLVSTPRLMEPVYLVEVISPIDCLNAIENVLTRRRGHIIHDLPKPGTPLHITKALIPVLDSYGFETDLRVHTQGQAFCLSTFDHWQVVPGDPLDKSIKLRPLEPSPKLHLARELLIKTRKRKGLSEDVNFGKHFDEQLLLSLSQNENQYR
The following text describes a protein:
Function:
Binds to all microtubule populations.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MSTNFNVGVAAEAKPSSRVLKPPGGGHSDIFGSSDVRQNPPRPKNNQQNSSNMNAVMGTMDPNESLDTGKQGGGGGGAAPSSTGGDNGSSAPAQNGSSNGGGGASADRQQATSERARVPPGGHSQGFW
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the CTLH complex.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MILKVVPTEYGEQDGELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDADISSVGIDGCWQTDSQRILSEVMVEHFFRQGMLDVAEELCQEASLSIDASQKEPFVELNRILEALKVRVLRPALEWAVSNREMLMAQNSSLEFKLHRLYFISLLMGGTVNQQEALQYAKNFQPFAENHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACSLLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTENNPPMKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MGEEISSTVNLDLNLGPDPELGLEPATNYARSDWGNGLAARESESLRRFRSRYRSRFRRIDMLPVLAETHSPAMELSQLLITSGNVVALPAGEGSMASGERVIEDSKKCENGSKVMAEDNVTEEKRDVEKSVGSDGSFFDCYICLDLSKDPVVTNCGHLYCWSCLYQWLQVSEAKECPVCKGEVSVKTVTPIYGRGIQKRESEEVSNTKIPSRPQARRTESLRTTLNRSGHIPTEIFRHLQDRLERESSTGERRARPSLNRFMTSRGVRAEENQSSEALVEPSSDEINDIDLILNNAPENEEENENLSSSRALATQRRWAQMYGRVSSFTLSSAERLADTYLITHALGRNQEQNSSPPVGVEDRDSFSSIVGVINSESQVETAAEINSMLTVSTSSSVRRHENSSRVSDVDSADSRPLRRRRRLA
The following text describes a protein:
Function:
Functions as a transcriptional repressor.
Subcellular Localization:
Nucleus.
Sequence:
MSRPAEPLPEPAANQAAREAGMAQEDNRRGQGLPSFYHGAPQELDLSNKAYKREAGGPYSVLVDSKLGKPHLHESEEQPYFREARPAAEARAVKEDRENSDDPEDEEEEDEDEEDEDEEDEEEDEVSYKREQIIVEVNLNNQTLNVSKGEKGVSSQTKETPVLKSSSEEEEEEEAEEDSGEEAATGDSQDDEENAGQKKKEKRGEKASVAQRRTRRAASVVTAPAAAAPSPPPAPRAARGRRKSAEPPKRKKRAAKEPKAPVPKAKCEEKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLPPAPAAPAPPVPSAANAPAPPVGLNPVGALPPRPIPHPVSHLHIHPHPHHPPHHLPVPPVPHLPPPPALFKSEPLNHRGQSEDHFLRHLAEKNSSAPHH
The following text describes a protein:
Function:
Transcriptional repressor that plays a role in various developmental processes. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes.
Subcellular Localization:
Nucleus.
Sequence:
MEFPDHSRRILHSLRDQQLQGFLCDCQVLVGTAHFLAHRSVLASCSPFFHMSCRERPDTRDLTLNNQIVTAPAFSLLLNFMYCGRLSFQEAPAEDVLAAASYLHMDEVVRVCKKKLQGRAPAEADSTRREEESSTAYHLAEREDVKLGQQGIECEQSGTRNVAFQGDEAEGSEQKVPGNAVYQIQEGAGSSRFQRQEAGGTGQRVAGSFGYQAQEVSGNRPRAAVNSRLEAHTIVEGGQEVAGSSGLGIQEGTGSGQVVAGSARGQGQQLSLSHQEVAGTSRFEVPKRTENEQPIPESVRFQQHDAPQSTVTLPTHRYPTEIQDTCASTQAAPSRNSPKRQEPAGSTQGTMGGSRYSLPSQESVHINNQVLTMPRMSLENHTEAGTTLSVSGSFRYSLQTSEPAGSTMATPATSRYCVQSPQFAGNAAVQPGASRIPLQAQEPTGSMQLAPARPRYTPQVQEPTGSISTPPGLSRYFLQSPESAGTTQAVAGTSRYPFPTSASLIEKQREEGDCAKSELTVTTTTQPGMETAAASSPCSSTGSEVHSGVTVKVEAIVISDEECDRGAGSFKRHDFEEEEEEGEAESSYLPYHMIAVPGGHQPGYGTLLPPSIHAETMYLQDFEGHPGFPLFPEDVPTCKTCGKTFSCSYTLRRHATVHTRERPYECRYCLRSYTQSGDLYRHIRKAHSQLEPSLKKPKGEMEPAPPNLP
The following text describes a protein:
Function:
G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation. In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation. May be involved in hyperalgesia associated with inflammatory and neuropathic pain.
Miscellaneous:
MISCELLANEOUS: The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSQPERDNCSFDSVDKLTRTLQLAVHIPTFLLGLVLNLLAIRGFSAFLKKRKLDYIATSIYMINLAVFDLLLVLSLPFKMVLPQVESPLPSFCTLVECLYFISMYGSVFTICFISLDRFLAIQYPILASHLRSPRKTFGICCIIWMLVWIGSIPIYTFHREVERYKCFHNMSDVTWSASVFFPLEIFGFLLPMGIMGFCSYRSIHILLRRPDSTEDWVQQRDTKGWVQKRACIWTIATNLVIFVVSFLPVHLGFFLQYLVRNRFILDCRMKQGISLFLQLSLCFSNINCCLDVFCYYFVIKEFRMRIKAHRPSTIKLVNQDTMVSRG
The following text describes a protein:
Function:
Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). It could also play a role in the metabolism of some rare sugars such as L-fructose. Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. It can also phosphorylate L-fuculose and L-xylulose. It requires the R-configuration at the C-3 atom.
Sequence:
MTFRNCVAVDLGASSGRVMLARYERECRSLTLREIHRFNNGLHSQNGYVTWNVDSLESAIRLGLNKVCEEGIRIDSIGIDTWGVDFVLLDQQGQRVGLPVAYRDSRTNGLMAQAQQQLGKRDIYQRSGIQFLPFNTIYQLRALTEQQPELIPHIAHALLIPDYFSYRLTGKMNWEYTNATTTQLVNINSDDWDESLLAWSGANKAWFGRPTHPGNVIGHWICPQGNEIPVVAVASHDTASAVIASPLNGSRAAYLSSGTWSLMGFESQTPFTNDTALAANITNEGGAEGRYRVLKNIMGLWLLQRVLQERQINDLPALIAATQALPACRFIINPNDDRFINPDEMCSEIQAACRETAQPIPESDAELARCIFDSLALLYADVLHELAQLRGEDFSQLHIVGGGCQNTLLNQLCADACGIRVIAGPVEASTLGNIGIQLMTLDELNNVDDFRQVVSTTANLTTFTPNPDSEIAHYVAQIHSTRQTKELCA
The following text describes a protein:
Function:
May act as a general Rab protein regulator.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MESNSNSNETMYGNPNINMGFVDSGNSNIGNNTGSMSPPPQQQQQPQQASSTPAGSVGIGGLSFSLGANGISLEPSSISHRVNAITSKIKEFKQERMETTRDWRSFVGSRQQYGLPNIKDTTSRIKENVVYFQSNYLILFLCFSVFFIITNPFYLLLLGVLLFISVYLHNSTTLTDIQRKIAYGIQAFLSIYFLLYAGSSIFWLVGATCCITLLHASFHSPNSTDETNIKFGDGV