lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Minor component of fimbriae. These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. They play an important role in invasion of periodontal tissues and are major virulence factors. FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response.
Miscellaneous:
MISCELLANEOUS: The name (major fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
Subcellular Localization:
Fimbrium. Cell outer membrane. Note=Probably synthesized as a palmitoylated precursor. Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide. Probably part of the fimbrium tip, as a part of the complex formed by FimC, FimD and FimE.
Sequence:
MKMKYFHHPSGLLPRLLLLLLLTMGAVACTKEDNPDQPTSDEVATVKMSLDDVEMRGGDLYSGEDLIKKVRIFVFREGLNGLWVLDKQKLFASGQSDFQNPFTISAHAGPRQIYVIANEPDALTTKLDKILFKKELEDMQAPDVNEPIVRPFTMTGMATATLNPQGTVQANISLNRIAAKITLDIKQVTPGSDVIKITKVQILRNAKNSRLLEGTNKPTGYWNWANACDLPLTNNGSAQSIIQASAPLYVYENIGSDSDSSGRATQLVVEALYNGIKTRYYAYVNDKTTTANHHYSIRRNHHYKLDGTITKMGEFSSLLLTTTVLPWTVENLDYGFLVPYVAEINPHAVITQDNVVTFENSLSFTVRIKGRDGSRWKATLDNGLEFGFDSGSAIDGAADGTTVYTIKVKALKPNGIGIQRRTNLFFTVDGKKVILDKNINPQPTDIKIIQQGL
The following text describes a protein:
Function:
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Sequence:
MTTAKADLSEFEQKLVDKAVEAMERAYCKYSNFKVGAALVCEDGEIIIGANHENASYGATICAERSAVVTALTKGHRKFKMIAIATELEEPCSPCGICRQFLIEFGDYKVILGSSTSDQIIETTSYGLLPYAFTPKSLDDHEKETEERHHQSETKNGH
The following text describes a protein:
Function:
Transcriptional activator of the arabinanolytic system. Involved in the regulation of extracellular arabinanolytic genes and in the regulation of the intracellular activities of L-arabinose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of L-arabinose.
Sequence:
MGQPETDDTQLPVSHQSHQPLKTKRFTRSQVACDWCHFNHARCDQTFPCSRCLNKGTRCEFTRGRRKRGRLPKVGTPGTARIEGINSSHTVSSASEGRGASVTQSLQTPEDPRPAPAHVLNHQDQMHAHDVVILSPGMEYLSSGSIVWPMQEAEKSPSAVGSLSPTRGAVSPCAGTAALTAGGSSAPLDYTNFAGLADLDAFILANLAAEPPIATLEPYSSLQYPVLQPLIPFIRAELTPELACGLLELYFTSAFSTHMHPVCHSIPCYVLRKASFLSRTNYRPSSPALLASMLWVASSDDHALASPLTTPYCRKKISRLLGSLTLDLMRSSTHTPFDKNGHAAAGGTAGSPASPDAFRDFALYLPTVSGGVQGFGYSVGSLDDVITCIHVASVLSLNDQNAFDLRWWQAAFTLARELQLNREIEPGPSIDSQGACFPHSPAASTPKPLDCVCRRSYGSTVLITEEQREERRRVWWLLYMMDRHLALCHNRPLMLLDSESKGLLLPLDEEAWWAGEIHSNSPDFNGPQCVMSGTGSLRRVFSDSTCHDPSLFGFFLPLMTILGQLLDINQARNHPMLGLGVLGEKTWETRLHEVLGRLDQYEASLYGFVARCGDRKSPSLADDDTAHCLHVQTRFWLAKTVKAYASYYIDLLHILQNGKWDPRSLAADHTLWASSLNLASAVPQALRAAESVRQVLHFDPNLSFMPTFFSAQLLQGGFYFLVLLEQLQDQAGEPFLSACETMLRAAESCTVTLNNGYLKGFCLVMRSTVAQARGRPITQYEVRQRWSAIAALHAWSG
The following text describes a protein:
Function:
Small GTPase that negatively regulates a MAP kinase branch, downstream of SLT2, of the PKC1-mediated signal transduction pathway. With its specific guanine nucleotide exchange factor (GEF), the heterodimeric complex DCK1/LMO1, relocates to mitochondria upon oxidative stress and triggers cell death. The DCK1/LMO1/RHO5 signaling module that mediates mitochondrial turnover under nitrogen starvation conditions via mitophagy. The DCK1/LMO1/RHO5 signaling module also plays a role in cell wall integrity signaling.
Miscellaneous:
MISCELLANEOUS: Present with 2180 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Lipid-anchor. Mitochondrion. Note=Localization to mitochondria occurs upon oxidative stress and is dependent of DCK1 and LMO1.
Sequence:
MRSIKCVIIGDGAVGKTSLLISYTTNSFPTDYVPTVFDNYSTTIAIPNGTASSPLELDNGNDKRGSLSSASSSPSTDRKLYKINLWDTAGQEDYDRLRPLCYPQTDIFLICFSVSEHASFANVTEKWLPELKQTSNIEGTSLYTKLGKYPILLVGTKSDLRDDPATQKKLQEANSDYVSQEEIDELVQRCGFMGYTECSAATQAGVREVFEQAVRYAIYEPESPNQKSANHTLTDELTTATTNTNGDKNIREQKQQPHHNNSTDSTLPKGSLQQEKEALNIKPTKKGQKDKIHEQSKSKGSKIASNNHHNKQAKPKTRNDKKKKKSKCVIL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAQASLLACEGLAGVSLVPTAASKKMMLSQIASKQAENGERAGSPDVLRCSSQGHRKDSDKSRSRKDDDSLAESSHSKKTVKKVVVVEQNGSFQVKIPKNFICEHCFGAFRSSYHLKRHILIHTGEKPFECDICDMRFIQKYHLERHKRVHSGEKPYQCERCHQCFSRTDRLLRHKRMCQGCQSKTSDGQFSL
The following text describes a protein:
Function:
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAVLAGHASALLLTEEPDCSGPQTVVLFRREPLLLDCGRALSDVRVAFHTYGTPRADATLVLHALTGDSAVHEWWPDFLGAGRPLDPADDYVVCANVLGGCAGTTSAAELAATCSGPVPLSLRDMARVGRALLDSLGVRRVRVIGASMGGMLAYAWLLECPDLVEKAVIIGAPARHSPWAIGLNTAARSAIALAPGGEGLKVARQIAMLSYRSPESLSRTQAGQRVPGVPAVTSYLHYQGEKLAARFDEQTYCALTWAMDAFQPSSADLKAVRAPVLVVGISSDLLYPAAEVRACAAELPHADYWELGSIHGHDAFLMDPQDLPERVGAFLRS
The following text describes a protein:
Function:
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTILIDRDHGMSSPALVPAEGDLARDHAGAELTIGLINNMPDPALKATERQFMKLLQAAAGPRRIRFHCFSLPSVKRSPEAKWHVESEYSDLADLKRQRFDGLIVTGAEPVAPELDQEPYWRDLTDLVDWARTNTRSTIWSCLAAHAAVLHLDGIARRRLPAKCHGIFDCEAVTGDPLTHALPAPLKVSHSRLNEIVESDLEQAGYQVLTRSALAGVDVFVRQYASRFVFFQGHPEYDALSLQREYLRDVGRYLVRERDNYPHLPVSYFDAATEEKLVRFEKQARHQRHPALSNELPALNLRADIAAGSAAAALFRNWLQYLGADADASVLAR
The following text describes a protein:
Function:
Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
Subcellular Localization:
Cell projection, bleb.
Sequence:
MDPFTEKLLERTRARRENLQKKMAERPTAANRLIAKRARDPLTETNILPEQPAEAVQPSTKPSPSKRRCSDNKEAPATGEENREPVIQEAVPKTAETDRKPAVASLSSSARPAPEFDKKEEEIPAHSTRSIKSRMQKLVDQRQYWDNEGDAVDNGYISSIKPQRQDPSPPKQPLVSGSSETPAGRKGRFANLAATIGSWEDDLSHPSVKRNNAQAQPGTTCLSKPSATNGASACASSASVKPSTASYSQKTAEASLNKPVLSGEQSSVHLPVQSTRVVPPNPQKAETPEPRSVLPTNRNIPSSPQKTTRLTTQSASNTGRLISSPQKINLPSHQAALPPRSVFSPSPKKPELSKAQASGEIGRFNSQSPQKSQPPKELPAFQAGKVSPNVRKTEVNSTPQAKATSSAPLTREQLVKDGSLQQPKNTAVTPGGSGVKSFLERFGERCQERTVQSPPYSAQGHRTPAVTPNTKQVQERLKSHQSGTATADLAQKQKQERERELASIRNRFQKGSMWKSDKNESSDTKDLPSSSGIAYEPLGQPRDTPQSESKPASHPEDVTPTSSSLKSSGTSLNSLKEDAIVSSSSTSSPLKKVAFTEEEKNLPEPLEDKREKQDISAGNQEIEMNVDEEINSAGVIDELFDEEDDNEQRPRSPLAKLPGQDRLEDEEEQDVEDDEDPLNISSMSLLTPLAETVASVVTSPEASTPTSTAREKGKTPEGKRPTRYQRARVHRAESIESVDSVADDQNLLYSIDAYRSTRIKEVDRPHVKQVIVRKEDVSQKLEENRSVGQVNIKQKMKFFNNEINMQQTVIHQASQALNCCVDEEHGKGSQVEAEAERLLLIATERRAALLKELNKLKGEGPSAQKKTPSTCKAQDASCSASKGSISLFELRLPLKADFVCSAHKPESANYYFFIMIRAGAENTVATPLACTQNALSGDALSFPTKFTLSDVSNDFEIDVEIYCLVQKRELPSDKRKKANKSKAITPKRLLTSITKSSLQTPVMASPGGPNAVRTSSFALVGSHKLTLTSIGKNKFVLDKMKYEGNDKQLLGDMFQYKVPFLCPLEGHIYLKLQCQVGSSIEERGFLTMFEDVSGFGAWHRRWCVLSGYCISYWTYPDDEKRKNPIGRINLANCTSRKIEPANREFCARPNTFELITVRPQREEDKETLVSQCRNTLCVTKNWLSADTKDERNLWMQKLNQVLVDLRMWQPDSCYRPT
The following text describes a protein:
Function:
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA and from uracil-35 in the anticodon of tRNA(Tyr). Can, to a small extent, also react with uracil-2605.
Sequence:
MLPDSSVRLNKYISESGICSRREADRYIEQGNVFLNGKRATIGDQVKPGDVVKVNGQLIEPREAEDLVLIALNKPVGIVSTTEDGERDNIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITEEFIRGMSAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEHFGYEVKKLERTRIMNVSLSGIPLGEWRDLTDDELIDLFKLIENSSSEVKPKAKAKPKTAGIKRPVVKMEKTAEKGGRPASNGKRFTSPGRKKKGR
The following text describes a protein:
Function:
Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPWIQVYTPVAGSLGLSALVAAIPLVVIFVCLALFKMKAHKAGLLALASAMLIAITVWGMPAKLAGLATAQGAAFGLFPVFYIVITTIFLYNITVKGGQFEIIRASLAGVTADRRLQALLIAFCFGAFIEGAAGFGTPVAIAGATLAGLGFQPLYAAGVCLVANTAPVAFGAIGIPIVALAGVMGYGDDGMMKLSTMVGRQLPFISVIIPFYVIMIMVGWKKTIEILPAIIVCGVTFALSQWATATYLGPYLPDVTASLASIIALVLLLRVWQPKTIYTFAHEAPVTGATEHHYTTGEVFRAWSPYLALTVMVLLWGIPSIKTVLDKSTVEIEVKGLHNMIVKKVAKPEDTLTKIAAASAEIDRQLTLLSPADPKQAAIAAKLMELKAFETQLAAVEQGLVGQGAVLTDERLKACDIVSKKMAETQKLCKELVKTAAVPANQFKPLDKALADHLPLKVAAKYKFNFMSAAGTAILIAAFLSALICGVGFADTFRILGKTLYDMRFPALTVASVLGLAYVMNASGMTNCLGLIFTKTGHWFPFIAPFLGWLGVFLTGSDTSSNVLFGGLQKATAEQLGISPILTGAANTSGGVMGKMISPQSLAVATAATGMVGEEGTLFRFTLKHSIFLTILVGIIVYLQAYVLQWMIP
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MTDVQLQNIVTTFGISMMLLIILYHYLSRPQA
The following text describes a protein:
Function:
Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
Subcellular Localization:
Lysosome.
Sequence:
MTFSLLYSTALIMKLMDSFFFLALVPLALALENGLMRTPPMGWLSWERFRCNTDCKSDPHSCISEKLFMDMADRLATDGWRELGYVYVNIDDCWMAKERSATGQLIPDPERFPSGIKALADYVHARGLKLGIYGDMATLAPSLVEGTLWGVDMLKFDGCYSSSDVQAQGYPKMSRALNATGRPIAYSCSWPAYRGGLPPQVNYTLLANICNLWRNYGDIQDSWDSVLSIVDWFSANQDILQPVAGPGHWNDPDMLIIGNFGLSCEQARSQMALWTIMAAPLFMSTDLRAISESAKEILKNKLMIKINQDPLGIQGRRILQEKSHIEVFLRPLSHSASALVFFSRRTDMPYRYTTSLAQLNFTQDVVYEAQDVYTGQIISGLKAADNFTIVVNPSGVVMWYLYPTMYLDQYNIMAHLKIF
The following text describes a protein:
Function:
May be involved in tumor progression.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVFGNHAKTESGVQRENLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRSEATDLHRHSFAESLKVYPTQGRRSPQEGGSHVGRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSSSAPPLPPKPKIAAIASMKSPEADPVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV
The following text describes a protein:
Function:
Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.
Subcellular Localization:
Nucleus.
Sequence:
MSQIQDLKDENVEMDIDPQEQNEKKPLLLDELTKFTILHPYNYDSHIKLIEELKRLDKKKELSEARKTFQSIFPLSEDLWVDYLLDECKNCRTLDDYVRIKTLFDLAVQDYLSIKIWCMYLEFTLNLMDTSSFEQEQSELNGVITLTDAHSLFERAYQTCKFHFSKSQCVWTLYLEFLQTFGDALFEGEEEQEIVFKNKIYDFHIDRLKLPHEQIEETFTSLSTFVTNNWSPSEYEDVMVKSNKVYETTLKRNAKIFNKELLLNSANHSLEAYMDLINDESRRSTAELQYITTLYERAIVLYPLIPELWLQYTAWLSKVDFSSSQASSVAERATRNCSWIGRIWSIKLTYMTLSGASTSAVCEEKDRCLNSNLLVNFDEVIDFFSGFLKACLYLSSNEDKPQEFLKHQIHKVEDYLRKNHKGSKDARMRIELSKIYLYSEISDFESVEKCWSDMFHDFQNQALYWISRYISTMKYNPELAAETLKKSLYKNVDQPQLLFQFYQSIMDLNNDCFTNTSHLYDVLNAQRISFKRQLDSFAEETKQTVENTEPLKVPQADDTAALSKKRKPGQEGDVFKKSKPIEQHRNREELTVLVTNLPSDISENELKIFFKDCGNIIRIFILEDNQKDVKVAQIEFSETSEVLAAKTRDLKSIRGHEISVQIHVDTNLYVTNFPPTYDELDITKLFSAYGNVVDVRFPSLRYNTNRRFCYVQMRKPDEAHNALQLHKKLLEEKYPIQVFISDPLRRTPRSGAVYEGRELYVTNIDFKVNEKDVETFFRDYGQVESVRIPKRFNQHKGFGYVVMTTNQDAENALSAAGKQLGNRVLNVVLSKPRESLEKTRVSSNDNRTLAKSFETTESNKMSTPKKSFEQIKSKSLGVTNVDGTVNEARLRSLFESYGKLYRVVLHPEHEGAVVEFLDIHDAGKASLALEGHEIGGRLLHITTVNEMMHNVPSSMNHSDYNTSATRPRRLGSRTFQGFNSNHSNINSKKDDLDDKEMQIDAPKSNDDFRKMFLK
The following text describes a protein:
Function:
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Note=Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region.
Sequence:
MVRTKADCAGSSSGSYRKAVAARAPRKTFGSSSSGSNHDTSPTGKKSECKYAGGNPVCVRPIPTWQKGIGDFFGSPSTSQPEKENRIPSDDEEAGGSGAGKKPRKSRPLPPDPSEEAADSGDE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MMQMDLFYSLLPSSNPVESVTIGFFDGCHLGHQALLSFLTKFPSKSGVITFSQHPEHTLSNSPPETITSLEERVQLLAGCGIDYLAVLPFNQEIANQEAEPFIQSIYKTLRPSRIVLGYDSRLGKGGLGTAQTLRPFAASLGISLEEVPPLQIEGTIVSSRKIRQFLRKKDLCSAEKFLGRPFSYTGKVAHGRGIGASFGYATINLPLTHSLLPLGVYTCTIVIEGFSYAGVMNLGMAPTMQRHQLCLEAHILDFSEDLYDKSITVIPEQFLREEKLFSSKDELVLAIQEDIRQARLNKNR
The following text describes a protein:
Function:
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity).
Subcellular Localization:
Apical cell membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Note=Localized in the apical canalicular membrane of parietal cells.
Domain:
The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
Sequence:
MAALQEKKSCSQRMAEFRQYCWNPDTGQMLGRTPARWVWISLYYAAFYVVMTGLFALCIYVLMQTIDPYTPDYQDQLKSPGVTLRPDVYGERGLQISYNISENSSWAGLTHTLHSFLAGYTPASQQDSINCSSEKYFFQETFSAPNHTKFSCKFTADMLQNCSGLVDPSFGFEEGKPCFIIKMNRIVKFLPSNNTAPRVDCTFQDDPQKPRKDIEPLQVQYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKFLNVPKNTQVLIVCKIMADHVTFDNPHDPYEGKVEFKLTIQK
The following text describes a protein:
Function:
Involved in the export of flagellum proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MANERSKLAFKKTFPVFKRFLQSKDLALVVFVIAILAIIIVPLPPFVLDFLLTISIALSVLIILIGLYIDKPTDFSAFPTLLLIVTLYRLALNVATTRMILTQGYKGPSAVSDIITAFGEFSVSGNYVIGAIIFSILVLVNLLVVTNGSTRVTEVRARFALDAMPGKQMAIDADLNSGLIDDKEAKKRRAALSQEADFYGAMDGASKFVKGDAIASIIITLINIIGGFLVGVFQRDMSLSFSASTFTILTIGDGLVGQIPALIIATATGIVATRTTQNEEEDFASKLITQLTNKSKTLVIVGAILLLFATIPGLPTFSLAFVGTLFLFIAWLISREGKDGLLTKLENYLSQKFGLDLSEKPHSSKIKPHTPTTRAKTQEELKREEEQAIDEVLKIEFLELALGYQLISLADMKQGGDLLERIRGIRKKIASDYGFLMPQIRIRDNLQLPPTHYEIKLKGIVIGEGMVMPDKFLAMNTGFVNKEIEGIPTKEPAFGMDALWIETKNKEEAIIQGYTIIDPSTVIATHTSELVKKYAEDFITKDEVKSLLERLAKDYPTIVEESKKIPTGAIRSVLQALLHEKIPIKDMLTILETITDIAPLVQNDVNILTEQVRARLSRVITNAFKSEDGRLKFLTFSTDSEQFLLNKLRENGTSKSLLLNVGELQKLIEVVSEEAMKVLQKGIAPVILIVEPNLRKALSNQMEQARIDVIVLSHAELDPNSNFEALGTIHINF
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MPYTWKFLGISKQLSLENGIAKLNQLLNLEVDLDIQTIRVPSDPDGGTAADEYIRYEMRLDISNLDEGTYSKFIFLGNSKMEVPMFLCYCGTDNRNEVVLQWLKAEYGVIMWPIKFEQKTMIKLADASIVHVTKENIEQITWFSSKLYFEPETQDKNLRQFSIEIPRESCEGLALGYGNTMHPYNDAIVPYIYNETGMAVERLPLTSVILAGHTKIMRESIVTSTRSLRNRVLAVVLQSIQFTSE
The following text describes a protein:
Function:
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSVLHFYVHPSGHERAASEHTQRKLQGKLPALQSVKTELCYNVNWTAKSPPNAEEMKKLMWLFGCPLLLGDVAQESWLHPDSSDLLLEVGPRLNFSTPASTNVVSVCWAAGLGAVDRVETTRRYLLSFAHPPSTEMETIALATLHDRMTEQHFPHPIQSFSLGSISTPLNGHINILAEGRCALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVEAFDLAQSNSEHSRHWFFKGQLHMDGQELAHSLFESIMSTQASSNPNNVLKFCDNSSAIQGKEVQFLRPEDPTQPSCFQPHRALRHVVFTAETHNFPTGVAPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGYNLPWEDPSFQYPENFARPLEVAIEASNGASDYGNKFGEPVLAGFTRSFGLQLPDGQRREWIKPIMFSGGIGSMEAEHVRKEPPEPGMDIVKVGGPVYRIGVGGGAASSVQVQGDNTSDLDFGAVQRGDPEMEQKMNRVIRACVEAARGNPICSLHDQGAGGNGNVLKELSDPAGAVIYTSRFQLGDPTLNALEIWGAEYQESNALLLRPLDRDFLSRVSARERCPTCFVGTITGDKRVSWPRKPAAVAVGGRGTARVWAGGRESRRREGMSRMGVGGTQTGEQHIVLVDDREYPVGRNGHEDASLSSPPTPVDLELDWVLGKMPRKEFFLKRSHPVLKPLALPPGLRVRQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLHTPLADVAVVALSHQELIGAATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVAVDGGKDSLSMAARVGSETVRAPGSLVISAYAVCPDITATVTPDLKHPGGRGHLLYVSLSPGQHRLGGTALAQCFSQLGEQPPNLDLPENLVRAFSVTQGLLRDRLLCSGHDVSDGGLITCLLEMAFAGNCGIEVHVPAPGVDALSVLFAEEPGLVLEVQESDLAQVLKRYRVAGLHCMELGPTGDAGPHALVRVSVNGAVVLEEAVGQLRAVWEETSFQLDRLQAEPRCVAEEEQGLRERMGPRYCLPAAFPKASVPREPGGPVPRVAILREEGSNGDREMADAFHLAGFEVWDVTTQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPVARAELRRFRKRPDTFSLGVCNGCQLLALLGWVGGSPSEEAKETKETSLDSWPAPPGLVLRHNLSGRFESRWASVRVGPGPALMLRGMEGAVLPVWSAHGEGYMAFSSPELQAQIEARGLAPLHWADDNGKPTEQYPMNPNGSPGGVAGVCSLDGRHLAVMPHPERAVRPWQWAWRPPLFDTVTTSPWLQLFINARDWTRKGGC
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MASMQEVTLLILAGGRGERFGGSKALYEVRGRPLLSYLVERVSSLSKRLIISVKSDPEIYSKLFPDAEIVVDEHEIYAPIVGLMSSLAEVKTDYVAVLPCDSPLVDPELIILLLRRARGRGGAVPIWEDGRIEPLLAVYKTDDLRKSILDCWNKSDLRVRCAIESMDIVYVSMDEIRGVDPELRSFLNINTQKELELLNELLGDPLPRASTQELP
The following text describes a protein:
Function:
Mitochondrial transporter required for glutathione import into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MATREACGQFAAASAAMAAASSQNPSKATMTDPRFRIRPLQQVASACTGAMVTACFMTPLDVIKTRLQAQQQALLSNKCFLYCNGLMDHICPCGPDTPNPAAAKPAPRFSGTIDAFIKISRTEGIGSLWSGLSPTLISALPSTIIYFVAYEQFKARFTDIHYKYTRRPDTIAHDIPHPIPFLVPLLAGVSGRILAVTCVSPVELIRTKMQSQRMTHAEMFGTIRQVVQSQGVLGLWRGLPPTILRDVPFSGIYWTCYEYLKSSFGVVEPTFSFSFAAGAISGSVAATITTPFDVVKTHEQIEFGEKFIFSDNPPKQVATKSVAMRLASIYRMGGVPAIFSGLGPRLFKVAPACAIMISSFEYGKSFFYHYNIDQHNRSNQATKGPGS
The following text describes a protein:
Function:
Component of the terephthalate 1,2-dioxygenase multicomponent enzyme system which catalyzes the dioxygenation of terephthalate (TER/TPA) to 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylic acid (DCD). It can also use 2,5-dicarboxypyridine (PDC) and 1,4-napthalenedicarboxylic acid (NDC) as substrates, and preferentially uses NADPH which is the physiological electron donor.
Sequence:
MINEIQIAAFNAAYAKTIDSDAMEQWPTFFTKDCHYCVTNVDNHDEGLAAGIVWADSQDMLTDRISALREANIYERHRYRHILGLPSIQSGDATQASASTPFMVLRIMHTGETEVFASGEYLDKFTTIDGKLRLQERIAVCDSTVTDTLMALPL
The following text describes a protein:
Function:
Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Subcellular Localization:
Cell junction. Cell membrane; Single-pass type I membrane protein.
Sequence:
MARAQALFLALTFQLCAPETETPAAGCTFEETSDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLVVNASQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGIYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALVSPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLVAVSREDQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLVSRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYSVSLCYHYTLGSSHNQTVRECVKMERGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPGGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSVESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERPRRLRREPGSQDCFPVPLTFDAALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRLARKAACKESKQPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIIIIRKGRNHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDAHGYSPRGDQRGSGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGGRQEPMPAYDRHRVKLHPMLGDPDADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDMYGDIKITLVKTETLAEYVVRSFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPVVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLVSTDGDPNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLHQSNSAWPCPQYWPEPGRQQYGLMEVEFVSGTADEDLVARVFRVQNISRMQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAAVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETLDQYHFCYDVALEYLEGLESR
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MQASELTPKWYVAPVSIKDEAVVKNLKAKIQALGFNHEIVDVKVLKEREVHEEVYSLKSGKLPRSLKNTTFNKWFVLDDYRYLRVKISEKNLLGRYIYIKMIYSEDAWRIVRNFPGITGIVGSSGRGALPIPLDEKDANNLEQMLKGISINPSKRIMLTNTAIIEMDSDKFDEKFQYILKQKQAIQKPKEDEDSEIVDAEKLKEAFKKLQNSQEQDEWKEKATIIQSEQTKLDPSVLVPFLGKYEILDTDNKVEQLFEFSVGNLVEVHLTDTIHVQGQIKALYQGTVNKAVVEIELTSKTQLINLPLENLSFVEFE
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNFAALRVVRCMKVQSIVAGHRVPHVLTSCIRQPIQTINTSSAHNEISSQESFELRHQVSSMKKNNTNWVMYRAGSVGLLAAVAGCFICPGNAIVDFATITLIVHHNYFGIKSVLADYMPLFFKDGFTNMVMIAWLIISIVTLGLLYAFNYNNIGFSKAVNNFFKL