lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.
Sequence:
CDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKVEKAASVSTTSSPVAAYSSSVATSYSSSIATTYPSPVRTVYSSPASSSYPSPAHTAFPSPSIATTYPSGTATFQTQVATSFPSPAVTNNFSSQVTSALSDMTSTFSPRTIEIC
The following text describes a protein:
Function:
Glycosyltransferase required for the regulation of cellulose biosynthesis in the cell wall. Required for the biosynthesis of hexoses (glucose, mannose and galactose) in both cellulosic and non-cellulosic (pectins and hemicelluloses) components of cell walls. Required for the formation of arabinogalactan proteins which contribute to the strengthening of cell walls. Possesses low glycosyltransferase activity.
Subcellular Localization:
Membrane; Single-pass type II membrane protein. Note=Localizes in punctuate patterns.
Sequence:
MKPPRRWMYGRGGGKGKPAGLLLLGVFLCLSVVLLLLLHGSSPSLEGEGRKPEAVEAAGGGGEEEEVAVARAEVEEAPLPPGNARLAFLFIARNRLPLDLVWDAFFRGDKEGRFSIFVHSRPGFVLTRATTRSGFFYNRQVNNSVQVDWGEASMIEAERVLLAHALKDPLNERFVFVSDSCVPLYNFNYTYDYIMSSSTSFVDSFADTKAGRYNPRMDPIIPVENWRKGSQWAVLTRKHAEVVVEDEEVLPEFQKHCRRRPLPEFWRDWDRPIPAEAWKAHNCIPDEHYVQTLLAQHGLEEELTRRSVTHSAWDLSSSKDRERRGWHPVTYKISDATPALVKSIKDIDNIYYETENRKEWCTSNGKPAPCFLFARKFTRAAGLKLLDLSLIAANGASTM
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYIKGFIRANNTFLYQLVFDPIKRKLIPLNAYEDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTAMPAHSRSRSWDDKTCQKSANVSSIWHRNYSPRPESGIVSDAPQLKENPSTVGVERVISTKGLNLPRKSSIVKRPRSEELSEDDLLSQYSLSFMKKTKKNSSEGNKSLSSSEVFVPDLVNGPTNKKSVSTPPRTRNKFATFLQRKNEESGAVVVPGTRSRFFCSSDSTDCVSNKVSIQPLDETAVTDKENNLHESEYGDQEGKRLVDTDVARDSSDDIPNNHIPGDHIPDKATVFTDEESYSFKSSKFTRTISPPTLGTLRSCFSWSGGLGDFSRTPSPSPSTALQQFRRKSDSPTSLPENNMSDVSQLKSEESSDDESHPLREGACSSQSQESGEFSLQSSNASKLSQCSSKDSDSEESDCNIKLLDSQSDQTSKLRLSHFSKKDTPLRNKVPGLYKSSSADSLSTTKIKPLGPARASGLSKKPASIQKRKHHNAENKPGLQIKLNELWKNFGFKKDSEKLPPCKKPLSPVRDNIQLTPEAEEDIFNKPECGRVQRAIFQ
The following text describes a protein:
Function:
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSRRLLKAAEAIREVVANAIVTEVRDPRVRDVTVIGVEVSPDMREAKVKVSVMGDETQKNLSLRGLQNSAGFLQSKIANRMDTRYTPKLRFEVDRGQENAMTVSEILARIQQEKEGATDDRDQNDSGEDATPHSND
The following text describes a protein:
Function:
Transcription factor involved in DNA damage responses, morphogenesis, and virulence.
Subcellular Localization:
Nucleus.
Sequence:
MSSDQTPQNRNRGGDDSYNPRLQQQTSQIPSTGPDQGQQRERSQEQESDHEHQQAQQHLHQFQQSNLTPSTTAFPSSTSIPTFSKQDQGYHNQFSSPQSSYRKIGNFAQSSNAPFLNEPHPIYATNYQQNVPSQSQFQFDYSSPYIGQSQSQSQSQSQAQPQPHPQPQTYQQLPHYSQASVSSLPPTYQAFHSMHEASSADNDSATNITTPQKRKKQKRSESVTPNTGENELKQLALRSSNIPLSELAQKVKQLENDSTTTSVSLEQSKMKENKETQRQLFGMVWLLNSCDLAPTAVIPRNRIYARYVQVCADNNLAPVSPASFGKLVKILYPNITTRRLGMRGQSKYHYCGIKLTGDENMQSQLLNYQQKQKHQSQEQYNQQAQVGSSTSSAGLAGHQSPMSSCNSSVSYEESPGPIISRAHTPSFSPINTPTISMSKSLNDQLPSISHMKFIPNLFYLLNSNVATSSNPHEPIQLPSIYPYLSKDADHDIADTLYSLYKVHVNSIFEALRYMQLKKLFSSFSTFNNILTAPVLKLYTTESLAEWVMKCDLIMYKKMIRMLSKLQLQLLIPQEQLLQLKQIADGYIKTLSTSLINSKVSQNFVMMKLKLAKHFVNLLNRLIKVIETGQPASRILNDDNEKNTMTQDWMKLDIHGIICREMPCNDNNIDTLTYILTGEVVNLIKVKSDNEQAPTMSDFANYISNLPSRFPEVNTRLFLLLASNLLTTCLREISLSGGEGFGAWWIVRCWIDEYLAWSFEVGGFFQDDLQEIVAQQQLNVQLPPPSLSSLPQTQQQNPVIQEETGTQEESLGNIDLLETSFDFDAKTSQPYQQPSHTESLLNFETNIDNLLN
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MSLASTTEVLNRALLRRDSIWIPQISYRDLDVREYVMVIFEDILGGRKVILNRPKKMNTLNYETVSSRIRRMYEKLKTYESDPTIKIVILKAYGKAFCAGGDVTSAVNLAAFGKCKLLLKLDMMEKINSIKTTSFNVSGHWSFVMSFYCKQFSLDYLLATYKKPMLAILDGSVMGGGVGISIHSTFRIVTENTIFAMPEASIGLFPDVGASYFLSRLPGFFGEYIGLTGVRLDGAEMLALGLGTHFIPSKNLQSMEKAIEKMVATSDAISVATMSMVINKFAQEVNVKPDSVTHRLKMINQCFSGETCEEILSSLERLSMQVEEKWINHAITSMKTASPICLKIFLKTIREGRSMQIEQCLGNEYIALSHILRKTISNDFYEGARAMLIEKDKKPQWGPSKLEKVSDQMVAQCFSRSFSVDDDWLPLRLPPRFDETNDRRSKL
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKIKVRTLQNNEEEINVDPDDSILDLKKKVEVVLADMPSDKQKLIFSGKILKDEDKATDILKDNDTVIVMVTRRIINKNNQKEDINKESLSKIENNNNNNNNKSDDNINVTTSNTEEQKENKENKNDNTNDNIYNSFNNAESMLLTGDKLKESIDNICAMGFEKEQVKKAMILAYNNPNRAIDYLTNGFPNENVNVNVNENINNESNFSNLLNSENNPLLEENSSHPLSSNEETFRNSTFFNAIRDMALSNPQRLPELLQMIGRTDPSFLEYIRQNQTEFLAALQNYGNNINDHEEHSDDNLDNADDENAIQNDSFLQDVGQQVLSDPNNENINIPITPLNENEMESIKKLESLGFPKHVALEAFIACDKNEEMAANYLFENMNDFTSE
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MTWQEYVDVELIGSGYCKSAVIIGMDGTENAVSLHCHLEKNEIANLISLFGDSKKRQTGMKIKLKGTGCIIQYGGDRTITAMSEKEDEGFVIVKTKQVIIVATYGDYMKEEQCLLVVEKLADYLIQKGF
The following text describes a protein:
Function:
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
Subcellular Localization:
Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MLCLNCGDSLFYQQNPSIRRDRKTISNGSTMRFWRRRPMFRRSHLKILLIGNSGAGKSALMNQYVNNRFSSRYRATIGSDFLSKQVHIDGRMLTVQIWDTAGTERFQALGTALYRGSDCCLLVFDVTSASSFQALDKWHKQLLLQIEEQSAFPIAVIGNKTDLENREVSLEEAELWSRLHHATYFETSAKAATNVQEVFQWAVRAALKNRRISELPEPDSVRLETRPEGAHRDKCGC
The following text describes a protein:
Function:
Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels; Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSGMEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEHKATCSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLNRSLLKEEDPAVLISEVLRRKFALKEEDINRKGN
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MSTANKSPIDEFESLQSLMNDFSAKFDTALTQKRSAIINDKQLHYVKVNELKNQETQLQSDIEGLKQKEIKVKDTIKRTMEDLQMQQLKVDELARKQDSLLDEKDELQTEIDNLSSQVQTTTDSLEKSSNNLAEQLRKDYPELLKYEQHLGLKIEVIGQDSLKFVFSNIDPNDLDKEVWCELLVGGELFKVGDSFPPLAPDIITLLENEFNHHREFVKFLKTVRALLMDLI
The following text describes a protein:
Function:
Essential for male fertility and sperm motility (By similarity). During spermatogenesis, promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility.
Sequence:
MGKKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEVNVSGTRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSNIINDGFYDYGRINPGTKLLPLKELCLQEPSDLRAVLLINSKSYVSPPSSMEDKSDVGYGRSISSSSSLRRSSKEKNKKNSYHFSAGFGSPIEDKSEPASGRNTVLSKSATKEKGWRKSKGKKEEEKVKEEEEVMVVPKFVGEGSSDKEWCPPSDPDFSMYVYEVTKSILPITNIKEQIEDLAKYVAEKMGGKIPKEKLPDFSWELHISELKFQLKSNVIPIGHVKKGIFYHRALLFKALADRIGIGCSLVRGEYGRAWNEVMLQNDSRKGVIGGLPAPEMYVIDLMFHPGGLMKLRSREADLYRFI
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Subcellular Localization:
Nucleus.
Sequence:
NIKCVTLGSRKNLCINQSVTRLQSLHRINDKCLDLQKDKSSKSSGGCPYLTEDPVQMVTFDDTIHARIRDIEEIVQAGRKSATCPYYGARHTAKSSEIICIPYNLLLQRSTRESIGLRLKNNIIILGKYTLFCLLDEAHNIIESVNSLYSHTISLDQILDCKTHLSKYFERYKNRLAGRNMVYVKQLLVLLDTPYSAAKSAQESNHAMSVSEFVDKAGIDHFNLFKILTYLENSRLPFKLLGFAVSETRKENSETANFIPTSVSPLSFMQSFLASLTDPDVNGRIVYNYSTDPHHCVFKYLLLNPADCFAPILKQARSVVFTGGTMSPIHDFIEQLLPSVQHDRLDVFSCGHVINSTSLLPICVSQGPTGLDFNFSHEKRVDTNMMDEAGAAIANYSNVISGGIVVFFVSYSYLDAIVKQWKSGGIWTRISKKKKIFIEPTSVGEVDKVLQDYSSTISRSRQTDFSTSTLTGSMLLAVVSGKLSEGINFADDMGRAVIMVGIPFANIASIELQERMRFFDVQVNAKETGSGITGKEYYENICMRVLCFVTGRAIRHKNDYAVIIFLDMRFKRDRIVAKLPEWIRNCGLTFPNQFGPSIAMISKV
The following text describes a protein:
Function:
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEENINKNEFPELKNDTFLKACRGEEVPYVPVWIMRQAGRYLPEFKSVRADVDFFSVCRTPELACKVTLQPLDRFPLDAAIIFSDILVVPQAMGIEVQMIPGKGPFFPNPIRTIEDLSRVQFPVDVNKELGYVFDALTLTRKRLEGRVPLIGFTGAPWTLMTYCIEGSGGTTMSNSKSWLYKHPAESHKFLSMLTRVCIDYLLGQIKAGAQALQIFDSWSNELSPAMFKEYCLPYLVQIGKEVKAVHPEIPLICFAKGSNFALEDLSKSGAYDVLGIDWTIEPSVAREMVADRVSLQGNLDPCVLYCGDQVIRDQTQKMLQSFGTTKRLIANLGHGMHPTHPIEGPESYVKAVHELSKQMINK
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex.
Subcellular Localization:
Nucleus.
Sequence:
MGCQPGVSPAPPRAAAASTTTLIGLGPHGPKRKQDLDKICELKAKAWQIMNQFGPSALINLSSFSSSKPEPTGTPPQGPMANSTAVVKIPGPPGPGGRLSPEGNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSNTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.
Subcellular Localization:
Nucleus. Note=Colocalized in the nucleus with DNMT3B.
Sequence:
MASRRKSTTPCMVLASEQDPDLELISDLDEGPPVLTPVENTRAESISSDEEVHESVDSDNQQNKKVEGGYECKYCTFQTPDLNMFTFHVDSEHPNVVLNSSYVCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTINDLTFDGSFVKEENAEQAESTEVSSSGISISKTPIMKMMKNKVENKRIAVHHNSVEDVPEEKENEIKPDREEIVENPSSSASESNTSTSIVNRIHPSTASTVVTPAAVLPGLAQVITAVSAQQNSNLIPKVLIPVNSIPTYNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKHGVSWTPEEVEEARRKQFNGTVHTVPQTITVIPTHISTGSNGLPSILQTCQIVGQPGLVLTQVAGTNTLPVTAPIALTVAGVPSQNNIQKSQVPAAQPTAETKPATAAVPTSQSVKHETALVNPDSFGIRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRNSKSNQCLHLNNDSSTTIIIDSSDETTESPTVGTAQPKQSWNPFPDFTPQKFKEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKKSKALKEEKMEIDESNAGSSKEEAGETSPADESGAPKSGSTGKICKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKNGNLKWYYYYQSANSSSMNGLSSLRKRGRGRPKGRGRGRPRGRPRGSKRINNWDRGPSLIKFKTGTAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRSELGIELFEENEEEDEVIDDQEEDEEETDDSDTWEPPRHVKRKLSKSDD
The following text describes a protein:
Function:
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. MSRB family specifically reduces the MetSO R-enantiomer.
Sequence:
MGVQRLLRLRMASHSCSRPPAAALAPRAARPLSSLLLAPSPSTARPPSAPLSCAARPCRGHAHAAASASRGAAGRRPPSVAAMSSSTPPPGPVQKSEEEWQAILTPEQFNILRRKGTEYPGTGEYDKFFEEGIYKCAGCGTPLYKSSTKFNSGCGWPAFYEGLPGAIKQTPDPDGRRTEITCTACGGHLGHIFKGEGFKTPTNERHCVNSISLKFTPS
The following text describes a protein:
Function:
Probable transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKEHGAMRSVLNLIGSVMLPQDTSNCSDRHDTPSAPEFLSHLQPFQTVLLSIASFSTTIVLCLSLIHWFYVYKYVSIEKRRNKLYWLIAVFPVACSCSFIAMCVPRTAVILTCIGVLYYLMCLFVIVSLARHLFGGRESFSTCLQYDDRPIDFRSPPFCCIIPKLPTARSTEKNIRRLEWCVLQAPIVRSIIIFLDVVAVAEMREDATPYIRYSDMASLCSLLLAIFGVHTLARVTSNKLSAYCFMSMFRLVDISLLFFSAQQPMIFQNVLLRFNLISCGPLLNAQENAYFVCNFIITCEMLLLSVLATWLLAPRHNAMFDAYRPSMALSETTASLNETEQSMILDH
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Nucleus.
Sequence:
MVGAEAGHVSKNVSSEGDETDEEPEEDPEEAMDEEPEEDPEEEEIDTENEEDPEEDPEEEEIETDNEEDPEEDPEEEEIETDNEEDPEEEEIDTENEEDPVEDQEEEINEESYKEELPVENSHLLSATSGGIASQDCGNELSKDPEGKNGKKVVEASGSSGRKRQSRWDLQWEGETRQIDGNSKRRKTRWDNNDTKKDSFDSAGITNGLDLLKDRNVLSLKERLLETNKKLISSTCSAKKREKLINKSKLIISKLAKANLRQPTRSFVKKILVPVKEYPTYNFIGLILGPKGSTQKKMEKETGAKILLRGKGSGESGPLSDEELHVLVEAYNQRSLDAAVAMVEKLLIPVADENNDHKRAQLVELAKQRGTYKDKNICDLCKEQGHRKYACPLQESTFEAVCCDVCGSFGHLTLNCSVQRKLQESSGTVVDQTNLYVGYLSHEIDEQRLKELFLPFGKIEKTAVLRDLSTGLSKGYGFVKFEDPSDSAAAVTYMNGYKMNGKMLAVRVAGKKPVSGPPSQLGHHPNIVGPVYVPAVPMLPEASNEMNGSLGFPSSLSYCGPDSHIARTEASNISPYVVTSTTNNFSSGYDFCDRIPSLLPNSESVIFPGHPDYIGSQFNSYFTNPVMNETLMAEPEKKSATYSFASRFRG
The following text describes a protein:
Function:
Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKRKSKQQDLEKKKKLKQSQDEQLSTGLFNNVGQGQHQGDDDDEEGDEIDWDNQEMDYELIPRKITTKKTIEALPIKKSDGTIERVVREVEEEEEEEEEEEPEEEPELENDVENEPSKQENKENKEEGDIDTDDTLTPQEKLIQTKEEIAELGSKLIEDPEENIVCLTRLRKMSESKNFMTSQLSILALIPIFKSLAPSYKIRPLTDTEKREKVSREIAKLRNFEQNLVINYKAYIELLTKYSKISYSNSMNNNKITSDQLKRGNIALKAATELCLSSLRHFNFREELFTIIIKRLNKKPQHQQDYPIFIKSLRVLETLLKDDAEHGDITFDIIKIMTKSIKDKKFRVDESVVNVFLSISLLEDYDPNNNNNNKDDHHNTTLKPKLKKKDRIHLSKKERKARKERKEIEEEIQKAEQAITVEQREKYQAQVLKMVLTLYLEILKAGSSSSQLIDGDGKKTKNDASLLMGAVLEGLSRFGQMSNLDLLGDFLEVLREIMTDIIEEHKQSGDNDNDNDNDDESGGMYSGNELRTILLCIATSFSLVLNHNSMGKLPMAIDLSKFVSTLYIILTDLALDPDLEFSHKTLRLADPLSSSSLSNELENNKPAVNVSTKAELLLRCLDFIFFRSKNGTIPRATAFIKRLYILTLQTPEKTSLANLKFIGKLMNRYGENIKGLWNTEERISGEGNYILGIERQNKDKDVELERSNSGAATLWENVLLDKHYSIMIKDGSRSLMKNSKANTN
The following text describes a protein:
Function:
Acts as a chaperone for histones, such as histone H2A-H2B, and thus regulates the assembly of nucleosome cores. Involved in chromatin remodeling, especially during fertilization and early embryonic development. May be involved in sperm chromatin decondensation during fertilization.
Subcellular Localization:
Nucleus.
Sequence:
MASTVSNTSKLEKPVSLIWGCELNEQNKTFEFKVEDDEEKCEHQLALRTVCLGDKAKDEFHIVEIVTQEEGAEKSVPIATLKPSILPMATMVGIELTPPVTFRLKAGSGPLYISGQHVAMEEDYSWAEEEDEGEAEGEEEEEEEEDQESPPKAVKRPAATKKAGQAKKKKLDKEDESSEEDSPTKKGKGAGRGRKPAAKK
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S-like rRNA where it nucleates assembly of the head domain of the small subunit.
Subcellular Localization:
Mitochondrion.
Sequence:
MIIKVQKTFEKRLINAFMRKGNYIKAEKIYLKVVNRLSTIGIKNSYQFIRETLLKMTPIMGVVKKKRGVKELIYPKYLEPEMGEKLAIKWLKKTVAKFKGELLIENIVEEFVKASKDQGEVVKEKWALYKEVRYAISCNTRKGHHKSFVEQKLKATQRRKWY
The following text describes a protein:
Function:
Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail. SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules. SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription. May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (By similarity). May also play a role in ribosomal biogenesis.
Subcellular Localization:
Nucleus.
Domain:
In the context of the SIN3B complex, the PHD-type 1 Zinc finger delivers the H3 substrate to the HDAC active site. The atypical PHD-type 2 Zinc finger has a structural role raher than a substrate recruitment role, wedged betweem SIN3B amd the HDAC and stabilizing the SIN3B:HDAC2 interaction. Also interacts with SIN3B through the SIN3 interacting domain 2 (SID2). Interacts with MORF4L1 through PHD-type 1 in a SIN3 interacting domain 1 (SID1)-dependent manner; The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs).
Sequence:
MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKESRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSSKRTTSPSSDTDLLDRPASKTELKAIAHARILERRASRPGTPTSNASTETPTSEHNDVDEDIVDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKRTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNLTLSNRCQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICSGVPEESQTHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSPWDSEQTEKADIKPVIVTDSSITTSLQTADKAPLPSHYPLSCPSAVSTQNSLGCSPPHQPPTLEDISCSSCVEKSKKAPCGTANGPVNTEIKANGPHLYSSPTDSTDPRRLPGANTPLPGLTHRQGWPRPLTPPSAGGLQNHVGIIVKTENATGPSSCPQRSLVPVPSLPPSIPSSCASIENTSTLHRKTVQSQIGPSSTESRPLGSPPNATRVLTPPQAAGDSILATGANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRVHQLFPSRVQASPGNVGTHPLASGGHHPEVQRKEVQARAVFCPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDASLLQDGVLAEKLSLKPHQGPVLRSNSVP
The following text describes a protein:
Function:
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Sequence:
MQITREKWSKNFSEWFDWVLREGEFYDYGRYPIKGMGVWMPYGFKLRQNIIGIIRNFLDSTGHEEVLFPLLIPEDLLRRESTHIKGFEEEVFWVTKGGSTDLDVKLALRPTSEVAITTMENLWLKSYKQLPKKYYQIVSVFRYETKATRPMIRLREITTFKEAHTVHETYDDAQKQVEEAIEIYKKIFDTLTIPYVLSERPEWDRFAGALHTYAFDTIMPDGRAMQIGTVHHLGQNFSKALDFKIQKKDGSLDYPHQTSYGISDRAVASVIAIHGDDHGPVLPPSVAPIKVVVIPIPAKNEEETQQVMKYSIEICEMFNKNNITCLTDQDTEKTPGEKFYIWEIKGVPIRLEIGPRELISGTVFIKRRDNFKSYTVRKEEAINKIKELLNEIQEDLRRKAWEDLKSRIEYSNDIEKAKKILGNNSGIVEVPWCGSNECGLKIEELTNARVLGYPIEKREVNDKCVICKMNAKTVLRIAKTY
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEVDPSSSSSSDEECEPSVESAAYVHSASVKLSVGCEEAARTIAGVIKIDKEPSRSGARREVSSEGEYVVINIESRDPKSLSKSISNAVDMIELSAKTLKMCDSFTKTRENGLKRKLPDKSLP
The following text describes a protein:
Function:
Transcriptional coactivator for creb1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of creb1 'Ser-119' phosphorylation. Enhances the interaction of creb1 with taf4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of ppargc1a and inducer of mitochondrial biogenesis in muscle cells (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.
Sequence:
MTATPANSGSNPRKFSEKIALHNQKQAEETRAFDELMSDLTVSRVQFQKLQQLRLAQTRAQYYGGSLPNVNQISSSPNDFQPSFHPMDNIRGMRHHGLVERVSRNRLHSSHHRPVEKHGRQCDSSPYGSVYLSPPPDNNWRRTNSDSALHTSASSSKLQDAFMGGNQAMLRAPKPPQRNPSLQDGEMNNFGEAFSYPTSMTEENMLNVTKPLPKQIWEAQKVQCITSRPRSCEVPGIKVFPSSDSNASLSHYQGSLNTGGSLPDLTNLHFPSPLPTPLDPDDTVYANINAENSSGLPAAMTHLGISNSQGIQNTCSNPSIQATMNNNVNNHTPPGRNNPTLHPSLRLSSLSNPSLPTSALGSSPRRRHTPVSPLTLTPGSESNRSISNQFSPTSPMDMLPNSQGVSMDRCPLSLPPLEPPPPYPLYTDQPQPQLHHTQQQMHESPESQNFQPPSPVPCPPLDLNLANSSLSGFFGDSFFDQQQPTKQGKYLWQQQEQYDMFGSPSSSLPNTNAFFDPNMNLQYSQASLMGLGGSHGSLQDSFHLRPNYLYSNYGGSVPNIILTDDSSNSLSKDISNAVAGVSELGFDADNTFQFDDELKLGPLSLDGLSMLSDPDMVLPDPSIEDSFRSDKL