lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MNDALDVTLRLLVVFVVFLTFPLIVGQTEHKVMAHMQGRLGPMYAGGFHGWAQLVADGVKFAQKEDVVPADADRRIFQLAPAVALLPYLLVLLAIPVGPGEGAVGQVVDAGVFFVLAVMGVGVLGSLMAGWSSANKFSLLGGLRTAAQLLAYELPMLLTAASVAMAAGTVSLVGILDAFEWWWLPWQIVGAIVFFVAGLAELQRPPFDMPVADSEIIFGAYTEYTGLRFALFLLAEYAGIVVLCGLTTVLFLGGWHGPWGADGLGWVWTLLKAAVLAFVVIWLRVTYPRLREDQLQKLSWTLLVPLSLAQIALTGIVKVVIA
The following text describes a protein:
Function:
Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (By similarity). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency.
Subcellular Localization:
Secreted.
Sequence:
MLRETWLCVILVAFVSHPVWLQKPHKRKTQLKAAGCCEEMRELKAQVANLSSLLGELSRKQESDWVSVVMQVMELESSSKHMESRLSTAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDEFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYQDWRQYKQGFGSIRGDFWLGNEHIHRLTRQPSRLRVELEDWEGNARYAEYSYFALGNELNSYRLFLGNYSGNVGKDALLYHNNTVFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHRKHMDGISWYGWHGANYSLKRVEMKIRPEAFKP
The following text describes a protein:
Function:
Potential regulator of CDK5 activity.
Sequence:
MASSSLSSLSSILSNPHGCSLCFKASTQRCFALRFLSSKATHASSSSSSALLPRCRSSTHRLTQKPINRKKGFSLNLSRSFSISQIASSGKFDGPSLHQFVSNAQAHASLTTPETESESTLDSDIASKGRIYHETYGCQMNINDMEIVLAIMKNSGYKEVVTDPESAEVIFVNTCAIRENAEQRVWQRLNYFWFLKREWKVNAATGRAKSLKPPKVVVLGCMAERLKDKILDSDKMVDVVCGPDAYRDLPRLLEEVDYGQKGINTLLSLEETYADISPVRISENSITAFVSVMRGCNNMCAFCIVPFTRGRERSRPVESIIREVGELWESGVKEVTLLGQNVNSYNDDSADRESGANWEYSEGFSSRCKVKNMGLRFADLLDRLSVEFPEMRFRFTSPHPKDYPDELLYLMRDRHNICNLIHLPAQSGNSRILEQMRRGYTREAYLDLVKKIRSIIPDVAITSDFITGFCGETEEEHQETLSLVRAVGYDMAYMFAYSMREKTHAHRNYTDDVPEEVKQRRLTELIDAFRETTGPCYDSQVGSTQLVLVEGPNKRAPETELIGKTDKGHRVSFVTKPLFDKACLLDGDDLKRNPGIGDFVEVQIEKSTRASLFGEALAISKMSLFHDVGVVDAVVASCAS
The following text describes a protein:
Function:
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MAKYNIALLFFVFFVWTSIILLVCDAIANSEESGKLHIVYMGSLPKEVPYSPTSHHLNLLKQVIDGSDIDTRLVRSYNRSFNGFAAILNDQQREKLAGMRGVVSVFPSQEFNLQTTRSWDFLGIPQSIKRDKVVESDLVIGVIDSGIWPESESFNDKGLGPIPKKWRGVCAGGTNFSCNNKIIGARFYDDKDKSARDVIGHGSHTASTAGGSQVNDVSFYGLAKGTARGGVPSSRIAVYKVCISSLKCSSDSILAAFDDAIADGVDIITASVGPIYTPDFLQDTIAIGSFHAMEKGILTTHSAGNDGSTPSTIRSVAPWLVSVAATTIDRQFIDKLVLGNGKTFIGKSINAFPSNGTKFPIVHSCPARGNASHEMCDCIDKNMVNGKLVLCGKLGGEMFAYENGAIGSIINATKSNLDVPSVTPKPSLYLGSNEFVHVQSYTNSTKYPVLSLPRGPNPIIPEIMKPDISAPGVDILAAWSPLEPPSDDFNNYDKRHVKYNIESGTSMACPHVAGVVAYVKSFHPNWSPAAIKSAIMTTATLVKGPYDDLAGEFAYGSGNINPQQAINPGLVYDITKEDYVQMLCNYGYDTNKVRQISGDDSSCHGASKRSLVKDINYPAMVFLVHRHFNVKIHRTVTNVGFHNSTYKATLIHHNPKVKISVEPKILSFRSLNEKQSYVVTVFGEAKSNQTVFSSSLVWSDETHNVKSPIIVQRIS
The following text describes a protein:
Function:
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
KGGKTQGRSAKSSRPEFDWRDPLVLEEQLTADEILIRDTFRTYCQEHLMPRIVLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQQQQKYLPRLAKGELLGCFGLTEPNHGSDPGSMETRALHNPSNRSYTLNGAKTWITNSPVADLFVVWARCEDNCIRGFLLEKGMRGLSAPKIEGKFSLRASATGMIIMDDVEVPEENVLPKASSLAVPFGCLNNARYGISWGVLGAAEFCLHTARQYTLDRIQFGVPLAKNQLIQRKLADMLTEITLGLHACLQLGRLKDQDKVTPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTTDK
The following text describes a protein:
Function:
May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.
Subcellular Localization:
Synapse. Postsynaptic density. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm, cytoskeleton. Note=Rather found at excitatory than inhibitory synapses.
Sequence:
MAPADLASEGPKLEDPPAPHLFGKCPSGLIMANVETLPVRADPGRDPLLAFAPRPAELGPPDPRLTMGSVGGGVTHAQEFPMKSVGTRTGGGGSQGSFPGPRSSGSGTNRERPGPGRYPSEDKVLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPNHPPKLLTTSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPAGLKGGLEKSRTMTPAGGSGGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTPGYSSGGGGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSQEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAACQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEVDAGGEGGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSRTPTPQHGEEEKAWTPSRLERIESTEI
The following text describes a protein:
Function:
Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Subcellular Localization:
Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cell projection, podosome. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. Localized to the core of myotube podosomes.
Domain:
The C-terminal tail is required for its GEF activity.
Sequence:
MHPASVTTTSQDPCAPSGSCRGGRRRRPISVIGGVSFYGNTQVEDVENLLVQPAARPPVPAHQVPPYKAVSARLRPFTFSQSTPIGLDRVGRRRQMKTSNVSSDGGAESSALVDDNGSEEDFSYEELCQANPRYLQPGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRNEDKEAWFPASFVRLRVNQEELPENCSSSHGEEQDEDTSKARHKHPESQQQMRTNVIQEIMNTERVYIKHLKDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLEHQEGFAIYSEYCNNHPGACVELSNLMKHSKYRHFFEACRLLQQMIDIALDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYNNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITRQGKSQQRIFFLFDHQLVSCKKDLLRRDMLYYKGRMDMDEVELVDVEDGRDKDWSLSLRNAFKLVSKATDEVHLFCARKQEDKARWLQAYADERRRVQEDQQMGMEIPENQKKLAMLNAQKAGHGKSKGYNSCPVAPPHQSLPPLHQRHITVPTSIPQQQVFALAEPKRKPSIFWHTFHKLTPFRK
The following text describes a protein:
Function:
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.smegmatis proteasome is able to cleave oligopeptides after hydrophobic residues, thus displaying chymotrypsin-like activity. In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin-like protein (Pup). Identified substrates of the M.smegmatis proteasome are the pupylated SodA and Ino1 proteins. The Pup-proteasome system (PPS) is essential for survival under starvation; PPS likely functions to recycle amino acids under nitrogen starvation, thereby enabling the cell to maintain basal metabolic activities.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFPYFISPEQAMRERSELARKGIARGRSVVALAYSEGVLFVAENPSRSLQKVSELYDRVGFAAVGRFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKAPELYRITYDGSIADEPHFVVMGGTTEPIIAALNESYTENASLQDAVEIAVKALSASAEGAEPRSLGPSTLEVAILDAGRPRRAFRRITGAALEALLPEQPQQADSGDKPTE
The following text describes a protein:
Function:
Confers the resistance against fosmidomycin.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAMSEQPQPVAGAAASTTKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQSEFSLTFMQIGMITLTFQLASSLLQPVVGYWTDKYPMPWSLPIGMCFTLSGLVLLALAGSFGAVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSIFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLAQISRWYSAQHRMNKGKPKATIINPLPRNKVVLAVSILLILIFSKYFYMASISSYYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLILPYASLHWTGVLTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLIADHTSIELVYKICAFLPLLGMLTIFLPDNRHKD
The following text describes a protein:
Function:
Calcium-dependent beta-galactose specific lectin.
Subcellular Localization:
Secreted.
Sequence:
MKGLVIFFCLFYGCHVAGATGKTIMLFPQKTDTDYVTLKPTERVLNQITVCLKSYTELIKEHSLFSLAMQGSGKDNTLLIYPYPPNNISISIHNEDIYFKVDPEVLQWKRTCVTWDSKTGLLQLWINGKLYPRRITKSRSPIGPQISVILGQEQDSYGGSFDINQAFVGEMSDVNVWDYVLPPENIKAYFSDDYTLDGNFYSWDGGNYTINGLIVVLRNQFIPKL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MVDIGMSAQRKRRAQRMANRRQRLALGPVSDHGDEILQAIEIVKAVLVKAKQEAQAYPGGDFPEESKDQQTDSSAISTSIPKQSYTLEPEISAHQNKSVDDEVIHMLQPKVSCQALKLDELVTFDMGWTVKSIITLKEIGRGSYGRVVIARHRSTGVPLAIKEPSWSDDFASPGEMVENLKATRTRATKEAMIQQLMSGSPYFPKFWGTLDLGNELCQAVEFVGCKKTGTGYPLHEPPSLSMCNVVKIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKHGKRYKAVIIDFGMASHRSPAVRELSKLGAQCMADNPDHRPSLDTIQSQITKLHRPSRWRRVKRWVAKKLHLRRK
The following text describes a protein:
Function:
D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. NAEs are bioactive lipids that are involved in diverse physiological processes such as growth and lifespan.
Sequence:
MSAPTTSSSTDEDFAKPVKNGKTFANPKSFTNWGGIPGISDGFKFAFTETNHENVPCDKKILDVEIPVHNITADDFHSESDLFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKKITDRNPQIKWFVPLGMKKWMEGQGIGVDGSSTAVTELNWGESSEFVKNGKTYTIWCLPAQHWGQRGLFDRNHRLWSGWAVIGENRRFYYSGDTGHCDGEFKKFGEKLGPFDLAAIPIGAYEPRWFMKSQHINPEEAIEVHKLIRAKNSIGIHWGTYHMGSTEYYLEPRDKLKELMDAREDLKNTSFVTIEMGRIWEASDQ
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MELLKEVILESEEDTYKLAEEIAQLLKGSEVICLRGTLGAGKTTFVKALAKALKVKNPSAVRSPTFTLVNEYETDKGKLIHIDLYRVPDFDYSEFIGEGILAVEWEERDKPCDIILEIEILDENKRKVRIYRK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for transcription in the embryo and for phosphorylation of the RNA polymerase II C-terminal domain repeat.
Subcellular Localization:
Nucleus.
Sequence:
MSSNVLPMYASTPSRAFAHSKLSSQLRAALADNSPAAPISPAPSGSALSLDESSGISDRDVHSSQEQTAHLSEVDVKSIHSSDSEDEPAQNPLPEVPANCGPPTIPLNVLLDFAIQHVYHEITVLAELMQRKTNDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRISKRMDVCYSIDYLLDLQSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKLVTSRLNQLIESRLSRLSSGIPPNIKEIHINNGLATLLVPGEFEIKITLLGETEMTKWTLLNIKILVEDYELGMGLPLVHPLQLNQLHGVLQSRMNVSLNPIKEAFSFLHSFCVSLQLDVLFCQTSRLAAGRLRDNITIEKYDPKERVLVVGYWVKRSKSRRLTVGQVKCDAQYRVQIYEDPNDKLGGLKVRHFPHAPQLGRLDSGAGMLSIDRLLSETYVVRCKERLMRLRRILEAAEPRLEVKMTGISAPSLSLALLPDTSSKDEMMTVSVNSFCGKVLCNVHILSAEHEDVLAFGKALYSSQCSAHTIQMYLRKLRVALVIERYRRSVKALPVREVQEAELLPFAKECLGDAPAQRIILQFLRSEDYYLLVTFSPDEKAVVKTHIQLLEVVGDRAQFIQLEDDEMNGMHVKEAINQGTMRFSPSHKTSLQEECSREQRLAFAVATVEDRITYMYLAAELMKKGIGVDVRKDSAHVPGGLALHITDVKNVVPFEASEFFECCIRCCLRLDNRNRYTFQFEMCFENIPLVRDVPHGLPHRRDGEPKDRTSKDATWLQELNHINQSSPEKLVELIIHRLMRYLYMYKVVHQFSLAYEKHFKNYCNIEAYTFHKLVVSYGDNRDMLMILAFNVKSQAPGSSEDFFFLNFGQSMPHRQFNSTEIDWHQKPRWNPHSMMSQLMRDDLKETNDLVFTMHFLCETIRPLVAIGNFSRIRFQSQKSLSQLIGPDVHFPFRLKYHLYALDQTTLRLMQGNVILEIKLLEGCKIAVRDVSRYRPRCAGLFQLFSNIDSETTAIMNDEIAIPQSDNPQTAGPTMWTPEQFMDSLDERPEEIDPRMAITSQPILMSHDTIIKACDFKDTEGRITCPLDEYLCSISYLQRALLTLERMSPRATLNKNSSSNLSCGFVTIIDAKPDFIRFRASQMNGDGVNATSMVHYKIYLCPVAMTLKIRIEFEEGTNSAATADNLKTLTTYFEKVVFPCGDEYALQSYICLTRLTSFEATQSIANLMNVQMEHPPTSKCCVQLSLTYNNTSTKKLAPATKVDQPLQNIIFNVIVSQSRTSESFSVLRFIYRIKENFVVVPSANEKNKQMADEVNAETKTSGGNPIWNLVRLVMDRFNSGDWNPGNRDEPIISSVAPPTYVNPGSVAGPSSVAAPGSVSIQQPGSVLQPGSMMGPQSVNALQYGMHRQPMGGPQSMQMNPSSVGQPGSVGGPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGYPQWNPPSVGQSYHHPLHHQQYPPQ
The following text describes a protein:
Function:
Transcription factor. Binds to the consensus DNA sequence 5'-AACAAT-3'. Also binds 5'-CACAAT-3' and 5'-AATAAT-3' but with a lower affinity. Acts partially redundantly with sox7 during cardiogenesis, acting indirectly through nodal-signaling to induce mesodermal, organizer and endodermal tissues, which then interact to initiate cardiogenesis. Also acts as an antagonist of beta-catenin signaling.
Subcellular Localization:
Nucleus.
Domain:
Binds target DNA via the HMG box domain; The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MHRSSYCREETTLCQGVNSTWVPPADTVPEASLTPHSPPAPDSPAPSPKPGYGYSACEEKPGDPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKNLTSAEKRPFVEEAERLRVQHLQDHPNYKYRPRRKKQAKKLKRMDPSHHLRNEGYTGGQPMVNLSHFRELHPLGGSGELESYGLPTPEMSPLDVLEPSEPAFFPPHMREDPDPGLFRTYQHEMDFSQEKTLREISLPYSTSPSHMGSFLRTPTPSAFYYKPHGGSSARTPLGQLSPPPEAPALDAMDHLNHAELWGDFDLNEFDQYLNMSRTQGPGYSFPMSKLGGPRTIPCEENSLISALSDASTAMYYTPCITG
The following text describes a protein:
Function:
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3, COQ5 and/or COQ7. According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 952 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Domain:
Adopts an atypical protein kinase-like fold: while it adopts a core fold similar to that of well-characterized protein kinase-like domains. The KxGQ motif completely occludes the typical substrate binding pocket. Nucleotide-binding opens the substrate binding pocket and flips the active site from inside the hydrophobic core into a catalytically competent, solvent-exposed posture.
Sequence:
MVTNMVKLRNLRRLYCSSRLLRTIQNGRISSVSSISLSKKYTTKSAKEGEENVERKHEEEKKDTLKSSSVPTSRISRLFHYGSLAAGVGMNAAAKGISEVAKGNSPTWKSLILSDSNIDRITNKFSKMRGVALKIGQLLSFQDEKVLPKELYEILSRVQNSANHMPQRQLEKVMAKELGANWKTKFSKFDKIPMAAASIGQVHAAELPSGQRVVVKIQYPGVKESIDSDLNSLLMLLTASSLLPKGLFLDKTIANARTELKWECDYNREARALQKFEALLKDDPAFEVPHVFPEYTTDNIITMTRMEGTEIMKLPKASQETKNFISENIMRLCLEEIATFKYMQTDPNWANFLYNGRTKKIELLDFGASRPFAEDFILKYRKLLTYATLRDRKGAYEMSVQLGYLTGLESQSMKDAHVDSVLTLGEPFRGDVDKSFDFKDQTVSDRIRGNIGLMLNERLCPPPEETYSLHRKFSGIFLLCARMGASVHCAKLFKEIFAYKV
The following text describes a protein:
Function:
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
Subcellular Localization:
Secreted.
Sequence:
MQPRVLLIAALLALLATAAEDKDASLLDVVQGYMQQASKTAKDTLTSMQESQVAQQARDWVNDGLSSLKDYWGKLKGKFSSFWDSTFEDTTPSPAVA
The following text describes a protein:
Function:
Effector of non-apoptotic necrotic cell death that mediates plasma membrane rupture (cytolysis): oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules that propagate the inflammatory response. Also acts as a homophilic transmembrane adhesion molecule that promotes cell adhesion by mediating homophilic interactions via its extracellular region (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
Composed of 4 alpha helices: 2 hydrophobic transmembrane regions (alpha3 and alpha4) and 2 alpha helices (alpha1 and alpha2) (By similarity). Alpha1 and alpha2 feature one hydrophobic side and a hydrophilic side (By similarity). In normal conditions, NijB is inactivated and alpha1 and alpha2 helices are not inserted into the membrane (By similarity). Following NijB activation, alpha1 and alpha2 helices insert into the membrane and drive NijB oligomerization via interactions between alpha3 and alpha4 and the hydrophobic face of alpha1 from an adjacent subunit (By similarity). Such structures disrupt membrane integrity and form a lesion through the introduction of the hydrophilic faces of alpha1 and alpha2 into the hydrophobic membrane (By similarity).
Sequence:
MDSGEVKISLEDSPSSGESFASTTSGPCCGSGRDLDIQVHESHIKDDQFPSRATSELQESKKSNKKCSSDLSTENSYAANKNVAEGLMDIALLSANANQLRFLITYNDKASTYIYSMIMVILSLVLQLLVGIMLIFKRRLKRFRNRSYERTNDLLVMGVFMITVINILLAAFTTTDGGGSH
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.
Sequence:
MALAALESCFRAVPPEAVAAVVDCVLASSPSASPSEFFRSLLDSFPKAQDGGHGHAAALSHAAALCHLLPRLGDDPRDALRALLWGVFLPLLRREDAQPSRLQQQATALMCDAVSSARSWDLLGATILPFCVRSCAAAMALPTTHQYDGDDSIVYRYHWDAAVAPDDGLSGEAGLLPLSRATALLASLLGDALKRRRETHEEGADASLDALVQNLTWDLSRLVLKMFDLGQEYRSCATRVLLQPMLTSLADVSCVTVEFGAVQLKLSRSGFLESIWNSCVSLFSLGRPERLDAYAILSLYFSVLKSGHQGAIPGADEVQNFDLRNVTEFWDELRRGLVDKDSSIRKQAFYVLKTSLSIFSFGNDGSQRCSGRSPAALPGQDKSNAAVTKKERWANKEAKSLGVEEIKQSDEQCSSGQDRWKVFLLLYEMLQEFGTHLVEAAWAHQVLLLFESTPQSDYLNHISYRAFHAQMESVEGIFNWMTVLWERGFTQDNPQVRCLVMQSFLDIEWERYKGYAQMVPRGFVLGPLIRGLNDVVHHKDFGVGGVYNSEAIKGAERFFSNYARKLTIRERLHLVWSLASAAKQDSFGRPGLMTLAFCTASCACQSDTHDLPCGSAVNELAKCNGDTSIAVNTADFLDALWVLSERSKHHFNPKYRLKVCEQVIKAVASLTSAAEIPLNQLFNFISTIPRECTDSTGPLRGTVQKWLLQKKECSERNTLLDELIDFPTTFMKHTGIEGSYLYDDEDVGAWEAEARRWARTLLLVTSEEHHFKQIFTFLENCGIKLSEHSSTRKCADVKFFIIIICLIEELEVRQKKLVHQNNAIAGGGSDMTNGLEHHALTQMFEKSLLSVLENMVAFSKQSCSVFWLKNTDMDLPCSIKGKLGGPSQRRLATSITSSVLQCIWSMRCASSVVSWCNHYTSDVSFHSAFSFLWEFCWEVIQHCTYATETGAELHLAAYEALAYVLAALCTAPFSQFLDFVEAKQTNQTIILSLDLLATTFLGNINNLLTNGVLTRSRRAVLMCWKWLCVDSLLSISGCCDENESQMKTLGSFYSDSTLQSIFLDITESLENAGENSVVSILRCVRSVLGLIHLNRSHQNLSSLGISYEMMMQLVKSSWVLHLSCNKRRVTPIAALLSAILHPSIFPNLEMHQTNEKGPGPLKWFVETLLNEGSKSPRTIRLAALHLSGLWLMYPKTLRFYMEELKLLALYGSVAFDEDFEAELSENHEARFEVSMLAQSPDREFTEVFINTELYARVSVAALFHQLWKQIKEKSKLEAEEALQCGKLFLLKLLDSAVNDNDLSKELYKKYSSVHRRKVRVWQMICVLSHYVEEDIVEEVTSTVHPCLYRNNLPAVRQYLETFAILIYLKFPTLAEAQLVPIFNDHGMRQQALSSYVFIAANVILHSGELVVQRNHLNQLLPPIISFLTSHHHSLRSFTQLLVHAVFSKLWHILQLESSENPSIERRCFQDLKKYLAENTDCARLRVSIEGFLDVFDPDISGTPPGIFTARIESSGFECVPVSVLERVNNFLNDVREELRHSMIKDSATIKNEGLAVRKHEEGTEEKIVASQDFQKKIIPHRDSEQAASSNSAVMGNNDISRLLFEMEEDDDTFNLAVESRKEAAETVRQSRQDLIVVASLVERIPNLAGLTRTCEIFRAGGLAVGDMGVVQDKQFRLISVTAEKWVPMVEVPVESVRAFLQRKRAEGYTVVGLEQTANSVALDEFVFPAKTVVVLGREKEGIPVDIIQEAVDVCVEIPQLGVVRSLNVHVSAAIAIWDYTRQQRARSSSSSSL
The following text describes a protein:
Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Subcellular Localization:
Secreted.
Sequence:
MGSGRSAGGCRGAALGVLLALGAALLAVGLASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
Subcellular Localization:
Nucleus.
Sequence:
MHIGILAAAAHAAANNSPFTVFYNPRASPSEFVIPLAKYYKSTYSSQVSLGMRFRMMFETEESGTRRYMGTITGISDLDPVRWKNSQWRNLQVGWDESTAGERRNRVSIWEIEPVTAPFFICPTPPFFRSKRPRLPGMPDDDCSDLDGLFKRTMPWLGDDFGMKDPQGLPGLSLVQWMNMQQNPSLANSMQQPNYLHSLSGPVLQNVGGGADLSRQLGLPAAPQLPQHNTLQFGTQRPNQQGQMPAATLSPVGSIVQSQQQQLSDISQQPRQNLINHSMPTNQVQAQLLQAQSLVQSQNVLQQQQSLQNQLQRNLPQQQQIMNQTQQQSFMPSQPSDPLNQQMHFSDNQLQLQLLQKLHQQQQSLLAQQSVLQQPQLGPIQDQQKQLLDVSQNFSRSLATSQMLDMSQTTSTSTSLSQSQVVQKQMTSQSHFRFSQPNQQSKLHQQPGILPELPGQVGQNLPPTTNQFSTNCSSLLTGAAGGGQSVVTDDIPSCSTSPSTNNCQNAVQPSMNGRMHRGTAAGDEATQSSVPLLNSSGFEAMSTNSNLVKDLQHKSDVKPSVNISKSPNQGFLAPQTYLNTAGPHMDYLDSSSSATSVCFSQNDAQLQQTTNPLSFNNQPVIFRDSQDGEVQGDPRNSVAFGSNMDNQLGLPMMPDPLVTNSLMDSRKDLSNNISSGGGMLSSYENPKEAQPELSSSMVSQSFGVPDMAFNSIDSTINDGSFMNRGAWAPPPQVPRLRTYTKVYKRGAVGRSIDIARYSGYEDLKQDLARRFGIEGQLEDRQRIGWKLVYVDHENDVLLVGDDPWEEFVNCVRCIKILSPQEVQQMSLDGDFGNSLQNQACSSSDGGNV
The following text describes a protein:
Function:
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (By similarity). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRWLIGGGREPQGLAEKAALQTIGEDQGQNPYTELLVLEAHRDIVRFLVRLDDFRFASAGDDGIIVVWNAQTGEKLLELRGHTQKITAVIAFPPLDSCEASSQLLLTASADRTVGVWDCDTGRQIQRVTCFQSTVKCLTVLQRLDIWLSGGSDLGVWNRKLDLLCKTSHLSDTGISALVEIPGNCVAAAVGRELIIFRLVTPTEELPEWDIIEVKRLLDHQDNILSLANINDTGFVTGSHVGELLIWDALDWTVQACERTFWSPTAQLDAQQEIKLFQKQNDISINHFTCDEENIFAAVGRGLYVYNLQLKRVIACQKTAHDSNILHIDKLPNRQLISCSEDGAVRMWEVREKQQLAAEPVPTGFFNMWGFGRVNKQASQPVKKQEENVTTCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILWKNGERESGVRSLKLFQKLEENGDLYPESP