lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase. When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MFACAGQPELVRANQKDVHYSSYLRENIGQVFRNFKGVHSWIKWKKELDVLADVCYFVLTTICGFQTLGEEYCNIVQVDQSKRAIPSTTARAAQVFLHTITPYLLNKLLMRLGSLAQSQEQWPPFASEGLRIWLKDNVPVIQQSILFLHRAHLAVFYLTGVFYHIAKRVTGVSYTLKDSASRPTYRLLGYLSAVQLAVTLLFKVYQKSKDSSVVDQWELSELPRKEEQPSVVPQSMPGTLKCSLCLENVKHITSTSCGHLFCWHCITEWCSSKCPLCREPLQMSRLVYLHHFEPT
The following text describes a protein:
Function:
Probable transcription factor, involved in posterior embryonic patterning, morphogenetic movements of the posterior hypodermis, and cell fate specification. May regulate expression of transcription factor dmd-3.
Subcellular Localization:
Nucleus.
Sequence:
MISVMQQMMNNSNMPPPFVKSSDSHETHDESPTSPFIKRSDSPATTSSAAAAAMQHNFWSTRAAQLQQSVSGSSGVSSGSSSSASNNLSRTQADNHSERGSDTASSPQVAPLPTSSGMSMPAAAAAGMYPFNAGRFPTEFNMMVNQSMYNDFYSNSLAASSWPYSYPQQYPFANYSMPSLDGNLNDGGQLEWTSSSHAMRKKRKPYTKAQTLELEKEFLYNTYVSKQKRWELAKYLHLTERQVKIWFQNRRMKDKKQKQRTSGDPTGMLMPPGLD
The following text describes a protein:
Function:
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPPKASKSKEAPSERPILGRFSSHLKIGIVGLPNVGKSTLFNTLTKMSIPAENFPFCTIEPNEARVNIPDERFEWLCQLFKPKSEVSAFLEIHDIAGLVRGAHAGQGLGNSFLSHIRAVDGIFHVLRAFEDPDIIHVDDIVDPVRDLEVISAELRLKDIEFIERRIEDVEKSMKRSNDKQLKIEMEMCQRVKAWLEEEKDVRLGDWKAADIEILNTFQLLTAKPVVYLVNMNERDYQRKKNKFLPKIHTWVQEHGGETIIPFSCILERNLADMLPHEADKYCEENKVQSALSKIIKTGFSAINLIYFFTAGPDEVKCWQIRRQTKAPQAAGTIHTDFERGFICAEVMKFDDLKELGSESAVKAGGKYKQEGKTYVVQDGDIIFFKFNVSGGGKK
The following text describes a protein:
Function:
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
Subcellular Localization:
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Sequence:
MSTLHKVKAYFGMAPMEDYDDEYYDDRAPSRGYARPRFDDDYGRYDGRDYDDARSDSRGDLRGEPADYPPPGYRGGYADEPRFRPREFDRAEMTRPRFGSWLRNSTRGALAMDPRRMAMMFEDGHPLSKITTLRPKDYSEARTIGERFRDGSPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MYRTAANRLFHDATLINNGGEGRLLRFPNLRTVISSSLFSTTVDPQPFPNQTLSPSDSSTVSSSTSSSTSSTSGGGPRDKRKNPRAAYEEEQARVLPASLRHVMRLGWSEEAMVAGAKDVGVSPSIVGSFPRKEAALVSVCLIIACCHVSLVHGNALIKINLKFFMDDCLQRLIDKTDSGEVLQNLIPSQHISKLVRIHLEKCKRPKYQNGLKLSAFNIKQLGMLADEIRHAAGYEASDVDCYVKCTVLGGIYSTTETYTLTDGLPEFRDTWLFLDDLVKDAFDLKKTIQEAKYLAEAVGAGMGSSLQGFVSRDES
The following text describes a protein:
Function:
May play a role in DNA-protein cross-links (DPCs) clearance, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. Limits replication stress and DNA double-strand breaks.
Subcellular Localization:
Cytoplasm. Chromosome. Note=During mitosis, associated with dividing chromosomes.
Sequence:
MADHKYRLFNAVDPSKVSHAPKDHPEKRNDQKTRKLPAAPMRANVGAPAPSCGANTEDTELDNSDYMEALQLSADGCSQDVANVGDVELLSAGISNLKVQPINEEHSAKPEISICISSTTEENVSGDDDAASCITISDSSEDEQEPLPPDSMAVSEREIVANPGQEDIPQPMLTTEKVQRIEAFLRDVSIERREMEWNGPLTPPPLSSSQRQSRLADADTESMSPTDEDWQPPTTRPIYNSTQLANNDTQVNTICSADATRLDSSKRLADDETEANTLGSEELEPTYSSKRLADNDTEPNTLCSDSSETHNSTIHNNEPVPDESIEIPETSSEGELTPQKASSGSSTSGGDEHGSIQVSSINISAKINIKISIPTMESSSAEDDDEHYSSPRATKSLPSSEEVQHQEHQQQDPQSHQKSMLSVDDASEDEQFLTHAEKLLNQLYGKSWQTPDVIRTLKRSSGSGGKQAPLRPRNIQATAVTTAKKKKPKPDESVLGDFSIFTKPLRTNQTPLNSTRLPPMRAVQTERRPRTQKPLTRPRTNHIDEDRWRKLIDSDSGTDASDDEDADATFSESGSDSDSDKDKENKQKRGDLTYLDLSKDEVEVISNPDQDSPSPKCHRRLDDILRSCRASVKAKLPATPVQQPNIRRQLFTPNAGFENDNQAKEIVNRALDLDMLDELESDYLPGTPVHRRVQEVKKKLGIGQQGQTTPHESPILKLLTPKTAPPKGTAPPKTSAPPKVSTPPKSTKQIPKPRKQKDLSPVASGGKCGFLKSLEGQVSRDRADNEAFFYRENFARNKDQLAQHLYKMYNAQVFNNELDVPITWSKLLRNTAGRCMNKRKLNQRSSVVELSVKVLTTADRLRCTLIHELCHAAAWVFNGEGGHGRVWKMWAQRANDKFPDLPQIKVCHNYSIEFKYTYKCLSCDKASHAHSRSRKVEDLRCRICRGPITLFLNKKDKQGNTVSTPAGEAKGFAKFVKDNFQRHKRDNMTAAQVMRILSVEYAKQKGQPAEETAASIASRVETLTLDESSN
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MATGSMRERVYRSEAVILRRTDFAEADRLLLIATPTGKRWVIAKGARKMKSRLAGHIELFTHAQMMFAVGRNLDIVTQSQIVHAFPVLRTDLTRLGCGYYVAELYDRLAAESEENPLLFQLLVETLQALDGSANPELTLRSFELHLLHILGYRPQLHYCVVCNELLTPAADRYSPTLGGVLCPRDRTADPAALSMNEPTFRLLRYLQAQPVTAAETLRISPATRQEAATLLRASLRLLLERDLKSAGFLDHLLSSQ
The following text describes a protein:
Function:
Involved in modulation of redox homeostasis to regulate leaf senescence mediated by age and stress factors during plant development. Its function is dependent of EIN2, a central factor of ethylene signaling.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing AAF exhibit increased root growth, elevated level of cellular reactive oxygen species (ROS), enhanced sensitivity to oxidative stress, and early leaf senescence induced by continuous darkness and by age-dependent signaling.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MALNVSKVVPNSPILVKSVNASRSRRVLLAYVHHPLAANKGSSIEELKQGLCCTKTVTFVSSRRCSTLCFVGKSQDTETNSQVVQKEGEKQVMPRRKSSNSSQLLVEYVSNDAKFVNERARNDFVLLSRGIMRLDARARQDVAILGSGFLKLDARAREDTEKIDRDVKRKAERLHHIATIFKNIAESKLKNAADKHWSDGALEADLRRADFRAKQRAMEDALMALEFIKNIHDMMVNKMVDSLVTSETGTTDRISLEKNGIALGFFPGEVSSDRISAIEEAYKSMASALSEADGIDYTDPEELELLVTTLIDLDAMDGKSSASLLAECSSSPDVNTRKALANALAAAPSMWTLGNAGMGALQRLAEDSNPAIAAAASRAINALKKQWEVEEGDSLRFMMNFERPNDDDDVDSDLDEI
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Subcellular Localization:
Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MPPYTITYFPVRGRCEAMRMLLADQSQSWKEEVVTMETWMKGSLKASCLYGQLPKFQDGDLTLYQSNAILRHLGRSLGLYGKDQQEAALLDVVNDGVEDLRCKYALLIYTNYEAGKEEYVKALPGYLKPFEKLLSQNEGGQAFIVGNQISFADYNLLDLLLIHQVLAPSCLDSFPLLSAYVACLSARPKLKAFLSSPEHGKLGGYLTSFLPDQ
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MNPHHRQPSQPTVGFPSHQFHPGLAHWGEHPSPERAQQVSACPYGASIGKDDSSYFFLETAKHPKPLPDVSAFTRLVSEMGSMSSAAGPIQGYFRPEQSYTGLKLLDYSAPDLPPGAHPSSSHSDSQQLYDLGFPEQHCTESDKKTPSDDVTPGSPLCPPQKGSSHGIIVINHNHHNNNNNCKADVAPGLLQDKPLSEFPAGDKTPGQDAQEDSKAESAATGWLTAKAGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVNLTDRQVKIWFQNRRMKLKKMTRDHRARDVTAHFSL
The following text describes a protein:
Function:
Protease that is part of the quality control system in the inner membrane of mitochondria (By similarity). Metalloendopeptidase that modulates the oxidative phosphorylation (OXPHOS) system and plant growth. Involved in tolerance mechanisms to heat, osmotic and oxidative stresses.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MKPSLKRRLLLLSRKFAKASIRKLLRQSSFSSHEFLLQAPFPAMSWYRRTKLVFDSLRRNINPKILPRSHVTSRINNPIGSSNPSAKFSSISSREVGLRSWTSLGRNTNRIAYNPFLSQPKRYYYVDRYQVRHFKPRGPGRWFQNPRTVFTVVLVGSVGLITLIVGNTETIPYTKRTHFILLSKPMEKLLGETQFEQIKKTYQGKILPATHPESIRVRLIAKEVIDALQRGLSNERVWSDLGYASTESSLGGGSDKGVKEMEMAMSGEDTMTDMKWSKEDQVLDDQWIQKSRKKDSKAHAATSHLEGISWEVLVVNEPIVNAFCLPAGKIVVFTGLLNHFKSDAEVATVIGHEVGHAVARHVAEGITKNLWFAILQLVLYQFVMPDLVNTMSALFLRLPFSRKMEIEADYIGLLLLASAGYDPRVAPTVYEKLGKLGGDALGDYLSTHPSGKKRSKLLAQANVMEEALMIYREVQAGRTGVEGFL
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNTRLALFILLFRWWNALWVQTFFQPDEFYQALEIAHNFVYGTGFVSWEWREGIRSAAHPLLFALVYKCLNLLHLDTVNSIFVAAPKLVQGTFAAITDVATFEFAKVRFGRRAAVWALVCSLLSFFNAYVSVRTFSSSLETTLTVLMFWQWELWQKAMKSRSTENVKIRHLLLFSLFFLLGFIIRPTNALFAIPIGLEWLYRLKKFSFRTFFPSTLSIVACLVLVTGLFLLNVYLDTWFYSRNIVPLISFLKFNVASGKSAIYGINTWHYYLTQGLPLICGFMLPFVLLGMTGRDYVRVLSILAPFSLLAHKEVRFVYPLSPILLSAAGYCISRCISRIRRQKIALVIFLLHSFIAFFLCRVHQAGVIEVMPTLKQLADANTTGVLLMPCHSTPWQSHLHSTLAETNWRFLTCEPSEYPSGEDIRFYEDMSAYLDAWENWPDYLVIFEERRPALEAYFAAHNLAYTQRARFFNSYIHDDSRRTGDVTVLRALRNNVNSVNN
The following text describes a protein:
Function:
Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy. Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Is likely involved in ribosomal biogenesis. Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes.
Subcellular Localization:
Cytoplasm. Secreted, cell wall. Host cell membrane. Note=Can bind to target membranes such as macrophage phagosomal membranes. In native and recombinant hosts (M.smegmatis and E.coli), M.tuberculosis TlyA can reach the bacterial surface in functional form and colocalizes with the HBHA protein which is known to be part of cell-wall. TlyA does not seem to depend on either Tat or Sec pathways for translocation to cell-wall. Appears to be capable of reaching the extra-cellular milieu using a vesicle mediated transport.
Sequence:
MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTTALTVVTDSERAWVSRGAHKLVGALEAFAIAVAGRRCLDAGASTGGFTEVLLDRGAAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLTPEAIGGRVDLVVADLSFISLATVLPALVGCASRDADIVPLVKPQFEVGKGQVGPGGVVHDPQLRARSVLAVARRAQELGWHSVGVKASPLPGPSGNVEYFLWLRTQTDRALSAKGLEDAVHRAISEGP
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MAAVVGATTKYSKCQYAWASVRKSGDNLQIHDGKPGPGAVAWGSFESEIHFSGYENNDLTKIGVHLQMKQLSGLSDIFENKTLNVSNEYLNVTKALYFNLDGDLIGLVGVVSKNSYNSIDRAPTCSALIKVVGENEDILVGHNTWFVYRSMLRIEKRYAFPWHYTSKSITETSLENADGSLWNLVKPDSAPLTWVRGMVATRLATNGSQWVSIFGRLNSGTYNNQWMVLDYKLFTSGKAIAKNTLWILEQMPNLTKSEDLSNYLQKQRYWASYNVAYNNYTHDPVSRCNCTQKYNPVSAISARFDLLSPSLSTGLPGVKQKAVGGTDMKLTNYAMFKKLEFVAINGPTYTTDGSVPPFQWSTSGFKHQEHDGHPDKWTFGPTHHHWDTCPIH
The following text describes a protein:
Function:
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock.
Subcellular Localization:
Cytoplasm.
Sequence:
MNRRFLYNCSAPVLDVKIAFCQGFGKQVDVSYIAQHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDCLFPADSEHNKLKASQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAARNQQISMPPPQIYDKQLDEREHSIDEWKELIYKEVMNFEERTKNGVVKGQPSPSAQVQP
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
Subcellular Localization:
Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex.
Domain:
The UMA domain mediates association with the ESCRT-I complex.
Sequence:
MASKKLGTDFHGTFSYLDDVPFKIGDKFKTPAKVGLPIGFSLPDCLQVVREMQYDFSLEKKAIEWAEDIRLIQEAQQEAERKSEEAEAKVNSKSGPEGDSKVSFSKTHSPATMPPPINPILASLQHNNILTPTRVSSSATKQKVLSPPHTKADFNPADFECEEDPFDNLELKTIDEKEELRNILVGTTGPIMAQLLDSNTPRGNSGSVLQDEEVLASLEQATLDFKPLHKPNGFITLPQLGNCEKMSLSSKVSLPPIPTVSNIKSLSFPKLDSDDSSQKTVRLASTFHSTSCLRSGASRNFLKPSTQSSASELNGDHALGLSALNLNSGTEVPALTSSQMPSLSILSVCTEESSPPSTCPTVTPLNFSVSQVPTMPSCPQAYLELQALSPSERQCVETVVNMGYSYDCVLRAMKKKGENIEQILDYLFAHGQLCEKGFDPLLVEEALEMHQCSEEKMMEFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLMARAEAS
The following text describes a protein:
Function:
Catalyzes the reversible oxidation of malate to oxaloacetate.
Sequence:
MQQPIPWEKVNRTEPLHVLITGAAGQIGYNLCFLIGRGFLFDCDVILHLYDLNDMALKGLSMELTDCCLPKLKGIISTTEIALAFSNVDVAIIVAGVPRKPGMQRSDLINVNKKVMEMNGKALGTYSNKDVRVVVVANPANTNAYVICKTSGIPPEHITALTRLDQNRATAFVANEVGCQPEFVHNIIVWGNHSNTMQPDLSYSYLADQNGIKPLANCIEDFDAFTEKVRCRGEEVISTRKASSAGSAAHAICQHIKDWIYGTKPGIMVSMGVSSNGEYGIDTGLFYSMPVTCSEGEYHIVDSLVIEPRIKDSLILSELELIDERNIVN
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Subcellular Localization:
Nucleus.
Sequence:
MLGNLQSETQPSKNVLDQYIAEINSKISGQNFKIERKTHEITGDLYYIFINTLSDEIVQESSVYTTAELTVIKYLIRNIIEASDYRCSLARVNANQTISTNTNKNLMEADSMVDRLIDDGWFISTIDDRLMLSIKTLCELKEYLIETYGVNGDDTDADGKVLLCTQCKEIVTLGWIIPSGSKPFHRKCYDVYCRTNQIYPEDESDLLRVGPDPSTL
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MRGMRGEVGEAGRGHVTGSGGSGRSRERKRRGLRRAMAEQIQKKLQGELEKYQQLQKDLSKSVAARQKLEAQLTENNIVKEELELLDDTNTIFKLLGPVLVRQDMEDARVTVAKRLQYITGEIKRYEQQMQEMEKRSEQQRELLARLQHDFQRAQSKA
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MPPKKHRHLTAEEKRELRKQKKLEKKQRLAEKKKQLKRDHLAREVNYGQLTIKKYEKNWREMLIKVALPRMRQELEFAWHNFERVVDCKDFTISLLMDELRDSEEQYMLNFRAHSENMEKLMWLFHDRLEELQADFESECKLMQERCENEFQDARELYNENFDYLKTMLHQLELERREHNRLKKGEYFSRLDEVEVKNQLLLQRLRATLERKYQNMFEDMKRFIKNYNKQIRERKKEHNLLKDQDDSIQELIAQQFNNIKKCYDRIRQLRQKYTDMKQIDGSRLSDLQAERNYFSNSFMTLKTKLENDKKDDFGKLALLSENAAKAFDCLEHLNKRGEMILTLAAVCRKLETQKEKILPFPRTTTNLPEIADIIDRDDAEEIEGVRPEMELFWQRLGQAFGVHYTLMREKNCLSDENQLLADTHNEYCERLMYPPIHSYMGRVTIPKTDTKLEMAKYDKFRGHTHKPFVHVTHRQQK
The following text describes a protein:
Function:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (By similarity). Along with gbb-1, may couple to the G(o)-alpha G-protein goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons. As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control of locomotory behavior. Regulates locomotory behavior in response to GABA release by GABAergic motor neurons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Alpha-helical parts of the C-terminal intracellular region may mediate heterodimeric interaction with gbb-1.
Sequence:
MSRWLSLLLFAVQAVGGYEAGEELSCKRRHGGIPLPLGVFTVQKEGFPDALPAIRTALSHVHSRSCILQGYRLEMIVKDTHCKTSQGMKALFDLIASRPRPVAILGGQCTEVNEPIAMALKYWQIVQLSYAETHAKFASSDSHELFTTFFRVVPGSRNTNMAKCKFVNHFGWKRVGTVKQNDQPRYALPHEALTTRLEHGFGVKIVHTAGVNWEQIETVGGELDELKERDVRIILVDVDEEMAATVLCAGYHRGMYGDNYVWILPGYHSDKWLNQTHDNCTVEEMREAAKNHFSVEFALTRRDVDTKIVGNTRAGDVWNEITQLDPNNTWRGYLYDGLWTLAIALSHSMGDNAEFSHHKMMEAIDNSSFQGLTGKVKFANNERLGLVDIKQWSDGQYVPFAVYDGADDEFKIIDSTTKGWSPPLDSTITERRREHISSILFLAMSLLALIGIFLALIFLLINFRYRNHRFIKMSSPNLNNIIIAGSICTFASVIMLGLDTRIVSPDVFVWLCYTKTWTLCIGFTLSFGAMFSKTWRVHSIFTNIRMDRKAIKDSKLFIILGILLFIDICVLVTWAFVSPFSYTVTELPHIPEDNIVIIPEVEKCNSSHSGVFQAVLYAVKGVLMILGCFLAWETRHVNVPALNDSKYIGTSVYCCVVMSVLGLSTSVILQERVNEMFSLASFFVIFSTTLTLCLVFVPKVIELARNPVGNEPRAYRRGLMKSVVAKTSQPMSPQPRSDSSGDLIGKAESENKLRRRYLHQKSTQLWDLVEKLRAQGDTRFLQQEWCLSSASPSSQERETSLLLRQPSSSNNREETSLTAAGPNGERSSDWPWVDPDEPSTKL
The following text describes a protein:
Function:
Acts on GalNAc (By similarity). Also acts as a galactokinase when galactose is present at high concentrations (By similarity).
Sequence:
MAAEDPATRRVQVAEHPRLLKLKEMFNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVGPVKTQTLQLANTDPLYPDFSTTANNICIDKTQPLWHNYFLCGFKGIQEHFGLTQLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMRLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNVRVMECRLAAKVLAKHKGLQWDKVLRLEEVQSELGISLEEMLLVTEDALHAEPYSREEICKCLGISLEELRTQILSPNTQGELTFKLYQRAKHVYSEAARVLQFKQVCEAAPDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAKGSRLTGAGWGGCTVSLVPADTLSSFLASVHEAYYQGNMSRLAREKHSLFATKPGGGALVFLEA
The following text describes a protein:
Function:
Participates in the transport of viral genome to neighboring plant cells directly through plasmodesmata, without any budding. Multifunctional movement protein with RNA-binding, ATPase and helicase activities. Engages in homologous interactions leading to the formation of a ribonucleoprotein complex containing plus-sense viral RNAs (vRNPs). ATPase activity is probably required for vRNPs movement complex assembly. Intracellular delivery of TGBp1-containing vRNPs to plasmodesmata is facilitated by TGBp2 and TGBp3 (By similarity).
Miscellaneous:
MISCELLANEOUS: The genome of this virus consists of three linear, positive, single-stranded RNAs encapsidated in separate virions designated RNA-alpha, RNA-beta and RNA-gamma. Three proteins (alpha-A, beta-A and gamma-A) are translated directly from these genomic RNAs and the remaining proteins encoded on RNA-beta (beta-B, beta-C and beta-D) and RNA-gamma (gamma-B) are expressed via three subgenomic messenger RNAs.
Subcellular Localization:
Host cell junction, host plasmodesma. Host nucleus. Host cytoplasm. Host nucleus, host nucleolus. Host cytoplasm, host cytoskeleton. Note=TGB1 nuclear-cytoplasmic trafficking is required for cell-to-cell movement and systemic infection. Associates with host microtubules (By similarity).
Sequence:
MDMTKTVEEKKTNGTDSVKGVFENSTIPKVPTGQEMGGDGSSTSKLKETLKVADQTPLSVDNGAKSKLDSSDRQVPGVADQTPLSVDNGAKSKLDSSDRQVPGPELKPNVKKSKKKRIQKPAQPSGPNDLKGGTKGSSQVGENVSENYTGISKEAAKQKQKTPKSVKMQSNLADKFKANDTRRSELINKFQQFVHETCLKSDFEYTGRQYFRARSNFFEMIKLASLYDKHLKECMARACTLERERLKRKLLLVRALKPAVDFLTGIISGVPGSGKSTIVRTLLKGEFPAVCALANPALMNDYSGIEGVYGLDDLLLSAVPITSDLLIIDEYTLAESAEILLLQRRLRASMVLLVGDVAQGKATTASSIEYLTLPVIYRSETTYRLGQETASLCSKQGNRMVSKGGRDTVIITDYDGETDETEKNIAFTVDTVRDVKDCGYDCALAIDVQGKEFDSVTLFLRNEDRKALADKHLRLVALSRHKSKLIIRADAEIRQAFLTGDIDLSSKASNSHRYSAKPDEDHSWFKAK
The following text describes a protein:
Function:
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFRSKKSGEAAHG
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Sequence:
MMMLRDKAVVTVEQIIGCKGLWDFLHSPTKLILLELVSAELDPSKEKVEETGLEKDTIKAYAHGVIEGGNVKYEAEFKGGKILGRLVRLLLRMSTTKKYFWRKYSLLVSQRVRLLSSVILGFTQSTTILGKESSSLAREITDLLRSICLEQSYLPSQTPSGLRALRKEELKVLRGNGKGERKWFERVYDYDVCNDIGDPDCDPSKTRPVLGGKGLPHLRRCRTGPPPCPRDHESETKSNNVYVPRDECFSEVKQRKLGEETASSLLHALNPSLWRRIIGFPNLAAIDQLFDEGMESPPRGYISVEQFLIGKLHGIFITVWRFIGYHFGYNLCLWPFKAPQPMQRDRFFWLRDEEFVRQTLAGINPYAIKLVTEWPLQSKLDPDTYGPPESTITKEMIECEIKGYMTLDEKVRELKSTTLYGSPTLFLLNPNETLRPLAIELSRPPLDGKPQFWKKAYEPCGHSTGAWLWRLAKTHVLAHDSLYHQLVTHCLRTHGATEPYIIATDQQLSVLHPIYKLLHPHFRFTMKINARARAHLINADGIIESSFSLANYSMEFSSVAYDLEWRFDHQAFPADLISRGMAMEDPTAPHGLRLKSRITLSLMTGFFPGTSLKNWSLTMSTTTTQMQVSWSHEELQAWWTEIREVGHGDKKDESWWAVLRTPKDLIQTVTTIAWVSSGHHTAVNFGQYEYAGYFPNRPTIARRNMPNEDPSEEDWKSFIEKPETILLCRVKFEPKISGLSSPDASLAHRPRGEFTSRVKGMRKYICRALNINRTSK
The following text describes a protein:
Function:
Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MTLRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPGIKFNIRPRQPHHDLPPGGSQDGDLKEPTERVTRDLSSGAPRGRNLPAPDQPQPPLQRGTRLRLRQRRRRLLIKKMPAAATIPANSSDAPFIRPGPGTLDGRWVSLHRSQQERKRVMQEACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFDRQGILHRLSTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLSLIRAPRNLTFPRFKDRHSQEARTTARIAHQYFAQLSALQRQRTYDFYYMDYLMFNYSKPFADLY