lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis. Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. Involved in cilium biogenesis and controls cilium length. Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins. Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110. Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MIDSVKLRRDSAADFFSHYEYLCALQDSVPLPAVRACLREGVLDFNADRLRGVDWAPLLSTLKINKDLPLISIKSFFQPWLGDTGSDINKFCRSRVPAIRYKDVTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSTSLVHLSLANCPIGDGGLEIICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGASAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGSSAKSEYQWITSPSVKEPSKTAKQKKRTIILGSGHKGKATIRIVIWRHRGLATKKPVSSGRKHSLGKEYAPAPLPPGVSGFLPWRTAERAKRHRGFPLIKTRDIYNQLQQPGFPVTVTVESPSSSEIEEVDDSSESVHEVPEKTSIKQEALQEKLEECLKQLKEERVIRLKADKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLKDAGLGQLATMAGIDQSDFQLLGHPQMTSTVSNPPKEEKKALEDERPEPKQNALGQMQNIQVSICMQSAYNEGTLMKFQKITGDARIPLPLDSFPVPVSTPETLGTSNDNLGVPAAEQRQESFEGFIARMCSPLPDATSGTGSQRKEEELSRNSRSSSEKKTKTGEYTKKHSGKKHPGKDLHSCSDSPENRKSKGTGETSSLVNESIKSRSLKKSVSVKKENRIVTVSSKTNKSKSSPLEHSESDTLGSDFEFQESIHSLSRLSYD
The following text describes a protein:
Function:
Probable transcription factor involved in the regulation of fruit growth. Contributes to integument development. Controls organ size via cell expansion. Involved in the regulation of longitudinal growth of the fruit evenly throughout the radial axis. Functions redundantly with TT16/AGL32 to repress nucellus growth and promote its degeneration.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing AGL63 are dwarf, have few rosette leaves with a curly-leaf phenotype, and display small disorganized floral structures and addition of carpel-like, resulting in small abnormal siliques with few seed production.
Subcellular Localization:
Nucleus.
Sequence:
MRKGKRVIKKIEEKIKRQVTFAKRKKSLIKKAYELSVLCDVHLGLIIFSHSNRLYDFCSNSTSMENLIMRYQKEKEGQTTAEHSFHSDQCSDCVKTKESMMREIENLKLNLQLYDGHGLNLLTYDELLSFELHLESSLQHARARKSEFMHQQQQQQTDQKLKGKEKGQGSSWEQLMWQAERQMMTCQRQKDPAPANEGGVPFLRWGTTHRRSSPP
The following text describes a protein:
Function:
Exhibits ATPase activity in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MQSRLLLLGAPGGRGSPAARRVRLLLRQVFWGGPGSDARRLDVRLLHAGAGADKGDTVNIGDVCYRLKTPKSPELVPQNYISDSVAQSVVQHLRWIMQKDLLGQDVFLIGPPGPLRRSIAMQYLELTKREVEYIALSRDTTETDLKQRREIRAGTAFYIDQCAVRAATEGRTLVLEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLQDHTKTELDAWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLKLLYSIGSNVPAEKVSQLLSFATTLCSQESSTLGLPDFPLDSLPAAVQILDSFPMMSIKHAIQWLYPYGILLGPEGKMAVEGVLKRFELQDSRSSVLPEEVVRVERMPENQGFQALVTLRIAGKEVTIKVPAGTRPFSQPCASDHFIQTLSHKQLLAEMMQSHMVKDMCLIGGKGCGKTVVAKNFADTLGYNIEPIMLYQDMTARDLLQQRYTLPSGDTAWRSSPLVNAALEGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYMRLKEELQMSDEQLQKRSIFPIHPSFRIIALAEPPVIGSTTQQWLGPEFLTMFFFHYMKPLVKSEEIQVIKEMVPSIPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLAQYPNENLHSAVTKACLARFLPSLARLALEKNLADAAIEISTDKNLEPELEDYKCEVTSGSLKIGAVSAPIYNAHEKMKVPDVLFYDNIQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQSLTLQPSVKDGLIVYEDSPLVKAVKLGHVLVIDEADKAPTNVTCILKTLVENGEMILADGRRIVANSANVNGRENVVLIHPDFRMIVLANRPGFPFLGNDFFGTLGDIFSCHAVDNPKPHSELEMLRQYGPNVPEPILQKLVAAFGELRNLADQGTINYPYSTREVVNIVRHLQKFPTEGLSSVVRNVFDFDSYNNDMREILINTLHKHGIPIGAKPTSVQLAKELPLPEQTFMGYWTIGQSRNGMQKLLCPTETHHIDIKGPALINIQEYPIDRHEERSQTFTEECASWRLPLDEINLICDVATSHENEEKTLYVVACNPVSLYFMNMAGTSGYFVDLFDIFPRTASGVWQPFVTVAPLGNPLKGQVILHEQQSNIILLLDTTSQALRRLILPSQEFTSKKTSWWSKEEAETYKMCKEFSHKNWLVFYKGKGNSLTVLDVLEGRTHTISLPINLQTVFLVAEDKWLLVESETNRKYLLTKPAHIESAVSGVCQLYVLKEEPPSTGFGVTQETDFSIPHKISSDQLSSENLSSAVGQKIASPNRILSDENSYATVVVGFPDLMSPSEVYSWKRPSSLHNSRVTDSTFYGGKRKSGTPKQSNCVTLLDTNQIVRILPPGEVPLKDIYPKDVTPPQTAGYLEVTDLQSKKLRYIPIPRSESLSPYTAWLSTISDTDALLAEWGQGGVVTVDMGGCIRLWETGLEHLQRSLMEWRNMIGQESDRPMQITINRESGEDVSSPKHGKVDPDNVPHIGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHTVYQVSEAEKDAVPEEVKRAAREMGQKAFQQRLKEIQMSEYDAETYETFSGAVRRQVHSLRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLTGEKAIYKRRGELEPQVGSPQQKPKRLRLVVDVSGSMYRFNGVDGRLKRSMEAVCMVMEAFENYEEKFKYDIAGHSGDGYNIDLVPINKIPKDNKQRLEILKVSAFNYLYSVKTSTRLGKVFWSLKRVTEEATVIGMKKSSFFSFFLSCLFSFLPSFFLYFFSSFFLLGLHPWHMEVPRLGVELDLQLPACTTAHSNAGSLTHWVRPGMEAVSSWMLVRFVSAEPQREL
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MYPLRTKGHGSFLQIPTLEICPNYLSGHTSKHARAASFVSQRCEDQFKAAIMNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTLDVIFVFGFRTHFGGAKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKINISSAKGCRGGQVDSESLRIRLN
The following text describes a protein:
Function:
Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyze the cleavage of (S)-citramalyl-CoA to acetyl-CoA and pyruvate.
Sequence:
MTRLCRTFQTAPAAIPNDNSAKFLVSGLTSKGFQAPDWLVPDIEDGTAPSMKDEAVDNIIEHIPDHADDFAGDILPRVEWAYDDANARERGIEQVTRLAEAVGEELDGFVFPKVGRLDDVRDAAGVIADAERDAGLPEGTLEMAIILETAPGRSDLREICQYATDSRLSGLVFGPVDYTAELGGRTLDGERPRWDGLLEALSNETSAADIVAIGGPFDQLFHERAGVTYYNAEGYADQVAYEATIGIDGSWSLHPKQTEQANRIHMPTVEEMERDLHKIESFNEAKREGTGAVVVDGQMVDEATYKNFANTVKTVRAIDETHPAQTEAYYDDDLLARARDVELIFG
The following text describes a protein:
Function:
P-element transposase that specifically mediates transposition of P-elements. Mediates both; precise and imprecise excision.
Domain:
The THAP-type zinc finger mediates DNA-binding and specifically recognizes sequence elements in a bipartite manner using both the major and minor grooves of its target DNA site. Minor-groove recognition is achieved by a combination of direct base contacts and indirect sequence readout of DNA deformation through a variable, basic loop. By contrast, the adjacent major groove is sequence-specifically recognized by the central beta-sheet of the domain.
Sequence:
MKYCKFCCKAVTGVKLIHVPKCAIKRKLWEQSLGCSLGENSQICDTHFNDSQWKAAPAKGQTFKRRRLNADAVPSKVIEPEPEKIKEGYTSGSTQTESCSLFNENKSLREKIRTLEYEMRRLEQQLRESQQLEESLRKIFTDTQIRILKNGGQRATFNSDDISTAICLHTAGPRAYNHLYKKGFPLPSRTTLYRWLSDVDIKRGCLDVVIDLMDSDGVDDADKLCVLAFDEMKVAAAFEYDSSADIVYEPSDYVQLAIVRGLKKSWKQPVFFDFNTRMDPDTLNNILRKLHRKGYLVVAIVSDLGTGNQKLWTELGISESKTWFSHPADDHLKIFVFSDTPHLIKLVRNHYVDSGLTINGKKLTKKTIQEALHLCNKSDLSILFKINENHINVRSLAKQKVKLATQLFSNTTASSIRRCYSLGYDIENATETADFFKLMNDWFDIFNSKLSTSNCIECSQPYGKQLDIQNDILNRMSEIMRTGILDKPKRLPFQKGIIVNNASLDGLYKYLQENFSMQYILTSRLNQDIVEHFFGSMRSRGGQFDHPTPLQFKYRLRKYIIGMTNLKECVNKNVIPDNSESWLNLDFSSKENENKSKDDEPVDDEPVDEMLSNIDFTEMDELTEDAMEYIAGYVIKKLRISDKVKENLTFTYVDEVSHGGLIKPSEKFQEKLKELECIFLHYTNNNNFEITNNVKEKLILAARNVDVDKQVKSFYFKIRIYFRIKYFNKKIEIKNQKQKLIGNSKLLKIKL
The following text describes a protein:
Function:
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSRSLDSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNASPHYQNIKENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSPGHAMADTYAVVQKRGAPAGAGSGTQTGTGTGTGARSAEEAPLYSKVTPRAQRPGAHAEDARGTLPGRVPADQSPAGSGAYEDVAGGAQTGGLGFNLRIGRPKGPRDPPAEWTRV
The following text describes a protein:
Function:
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Sequence:
MSWLSRLNPRGPGSRSGRTAAPLSPCTADPETCLMVFKNHWRQVSWVLDQRESSSSSDDLTAVRNNTDQMLCLLAEERPAESSEGGFGVASMGPILELVITENILERLVQWHLCRGLDPDSQGALLKLFEMLIGQSQQPLLQHTAVLHPLLRLLGACADPELGCPLALENSLVLLLNQVCVSMARQPVILELLFRASPAQQGSTNLLIFSLLVPFIHRDGAIGQQARDALLLVMAASASHKAAARYIAENSYFCPVLATGLSALYSSLPRKIEVRGDDWHALRREDWMGVSSLVLFMNSLEFCNAVVQVAHPTVSSQLLDYLHNGFLVPVMGPALHKSSVDEMIASTAYLDLFLRSITETSLLKTFLRFILLHRHDNDTILDTLLIRISSNSRLCMVSLSLFRTLLSLNCEDVMLQLVFRYLLPCTHVMLSQRRAIRETDMYGKCADKFLSLIPECCRQYTAASSERDEDNPFWSKVLNSPGTDTPAAPRPSTPSRLSLFMRQHAGGGGSGGGNLSSSTSLESLQSGPSGSRPLSPDSPMHQHGHTDCLDWDAGFLEYLKDARRGIEVCSWACRDWSAPYDGENPSPNTAPPPPPPPASNPSMAMFPEHFSFHQGVSSSTPPGQQRAAIVAAARSEWSSSDRDSGEWDVTIGQNNCISLTPRSKKRSLQRDELLPKPVPPLIPSSSTAAPLSASHSMSSPAAHIPTSAITVNYQAMFNGTARQGDECSDSHDRGLEVKKVKRDLGEPQYLDENANQNGSMVSCPSLPKSLFSNRDIGDAKSFHLNQTSSQCSPSQLAPDASNSHGTCSDPPETNPSQQSVESLLEELLEQAPGDPQMSADANGQGISIEAFTLELRKLEDRVKERSRSACKHEPSAAETLPAEQQEEEEQLPTAPEAKGDASVMGAPSPARPINQPTSQPYTGPFMVVLFAKLENMLQNSLYVNILLTGIVAQLACYPQPLLRSFLLNTNMVFQPSVKSLIQVLGSVKNRIEAFAASHEDFPVMLRKAQQYLVARGKLDWTDLPAAVPTLRRSESLVKSRKPSLGDLILRHTNSPTRARNAAQLALAHVRDGGQSLHSALFRGGGGSGGGGASGLEKQAEALRVKNAVYCTVIFCEFLKELAALAQEHAVTLPFPQSKEAEE
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes.
Sequence:
MENEPDHENVEQSLCAKTSEEELNKSFNLEASLSKFSYIDLDKELEFKNDLIDDKEFDIPQVDTPPTLESILNETDDEDESFVLEDPTLLNIDTIDSHSYDTSSVASSDSGDRTNLKRKKKLPDSFSLHGSVMRHSLLKGISAQIVSAADKVDAGLPTAIAVSSLIAVGTSHGLALIFGKDQNQALRLCLGSTSVGGQYGAISALSINNDCSRLLCGFAKGQITMWDLASGKLLRSITDAHPPGTAILHIKFTDDPTLAICNDSGGSVFELTFKRVMGVRTCESRCLFSGSKGEVCCIEPLHSKPELKDHPITQFSLLAMASLTKILVIGLKPSLKVWMTFPYGRMDPSSVPLLAWHFVAVQNYVNPMLAFCRGDVVHFLLVKRDESGAIHVTKQKHLHLYYDLINFTWINSRTVVLLDSVEKLHVIDRQTQEELETVEISEVQLVYNSSHFKSLATGGNVSQALALVGEKACYQSISSYGGQIFYLGTKSVYVMMLRSWRERVDHLLKQDCLTEALALAWSFHEGKAKAVVGLSGDASKRKAIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDTVPVIVDYCLLLQRKDLLFSQMYDKLSENSVAKGVFLECLEPYILSDKLVGITPQVMKDLIVHFQDKKLMENVEALIVHMDITSLDIQQVVLMCWENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPPLNAGKTLTDEQVVMGNKLLVYISCCLAGRAYPLGDIPEDLVPLVKNQVFEFLIRLHSAEASPEEEVYPYIRTLLHFDTREFLNVLALTFEDFKNDKQAVEYQQRIVDILLKVMVENSDFTPSQVGCLFTFLARQLAKPDNTLFVNRTLFDQVLEFLCSPDDDSRHSERQQVLLELLQAGGIVQFEESRLIRMAEKAEFYQICEFMYEREHQYDKIIDCYLRDPLREEEVFNYIHNILSIPGHSAEEKQSVWQKAMDHIEELVSLKPCKAAELVATHFSGHIETVIKKLQNQVLLFKFLRSLLDPREGIHINQELLQISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQLHEVTAYLLEKKGDIHGAFLIMLERLQSKLQEVTHQGENTREDPSLKDVEDTMVETIALCQRNSHNLNQQQREALWFPLLEAMMAPQKLSSSAIPHLHSEALKSLTMQVLNSMAAFIALPSILQRILQDPVYGKGKLGEIQGLILGMLDTFNYEQTLLETTTSLLNQDLHWSLCNLRASVTRGLNPKQDYCSICLQQYKRRQEMADEIIVFSCGHLYHSFCLQNKECTVEFEGRTRWTCYKCSSSNKVGKLSENSSEIKKGRITPSQVKMSPSYHQSKGDPTAKKGTSEPVLDPQQIQAFDQLCRLYRGSSRLALLTELSQNRSSESYRPFSGSQSAPAFNSIFQNENFQLQLIPPPVTED
The following text describes a protein:
Function:
Probably involved in the defense reaction of plants against pathogens.
Sequence:
MQMSMSMSKAQILLAPPTFLVFFNLLIFISSTEAAPISFGWVQQEFLKAHNDLRSSVGVPPLQWDANLASFALDWATQRKQDCNYRRHSTGPYGENIFWQLYKETPPTGVVQKWFSEKKFFDEVNNVCKCQPEKEGCECGHYLNVVWKTTKKVGCSGFVYCNDQKGVYIVCSYDPIGNVKGVNPLNPGDLTTNSTNH
The following text describes a protein:
Function:
Involved in cell wall organization and biosynthesis.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP), enriched at bud sites and their neighborhood.
Domain:
The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
Sequence:
MFNRFNKLQAALALVLYSQSALGQYYTNSSSIASNSSTAVSSTSSGSVSISSSIELTSSTSDVSSSLTELTSSSTEVSSSIAPSTSSSEVSSSITSSGSSVSGSSSITSSGSSVSSSSSATESGSSASGSSSATESGSSVSGSSTSITSGSSSATESGSSVSGSTSATESGSSASGSSSATESGSSASGSSSATESGSSVSGSSSATESGSSVSGSSSATESGSASSVPSSSGSVTESGSSSSASESSITQSGTASGSSASSTSGSVTQSGSSVSGSSASSAPGISSSIPQSTSSASTASGSITSGTLSSITSSASSATATASNSLSSSDGTIYLPSTTISGDITLTGSVIATEAVEVAAGGKLTLLDGDKYVFSADFIIHGGVFVEKSKPTYPGTEFDISGENFDVSGTFNAEEPAASSASAYSFTPGSFDNSGDISLSLSESTKGEVTFSPYSNSGAFSFSNAILNGGSVSGLQRRAESGSVNNGEINLENGSTYVVVEPVSGSGTINIISGNLYLHYPDTFTGQTVVFKGEGVLAVDPTETNTTPIPVVGYTGENQIAITADVTALSYDSATGVLTATQGNSQFSFSIGTGFSSSGFNVSEGTFAGAYAYYLNYGGVVASSATPSSTSTTSGATNSTSGSTSFGASVTGSTASTSFGASVTGSTASTLISGSPSVYTTTLTYATTTSTVVVSCSETTDSNGNVYTITTTVPCSSTTATITSCDETGCHVTTSTGTVATETVSSKSYTTVTVTHCDNNGCNTKTVTSECPEETSATTTSPKSYTTVTVTHCDDNGCNTKTVTSEAPEATTTTVSPKTYTTATVTQCDDNGCSTKTVTSEAPKETSETSETSAAPKTYTTATVTQCDDNGCNVKIITSQIPEATSTVTATSASPKSYTTVTSEGSKATSLTTAISKASSAISTYSKSAAPIKTSTGIIVQSEGIAAGLNANTLNALVGIFVLAFFN
The following text describes a protein:
Function:
Involved in lipid metabolism.
Miscellaneous:
MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
Sequence:
MEAGRSADEVLYHNQSSVKLGELERYVITYELYQGDSIPADITLDSLWVKIKNTTKLSYKPAYLLGPFILYCDVRAKDYESSYKIICSADKPVFQSNLQAQQKFIAELSLHHIKPRYVWIVDIVSQILFNKETKVTFEIVVGNSKASLKRKIRCNDSLPDKACNILHTGLSVHRLTTADIWKVPRPIDMSQKSHLVILTHGFQSNVSADMEYLMEEIYKAQMNNPNERLVIKGYMKNACETEKGIKFLGVGLANYIIDELYDDSVGKISFIGHSLGGLTQTFAICYIKTKYPYFFKKVEPINFISLASPLLGIATSTPNYVKMSLSMGIIGTTGQELGLKDGNYGDKPLLYLLSEESLISVLARFKRRTLYANAVNDGIVPLYSSSLLFLDYSQLLQKLGGQTTAPCDPLFQPEVSPIGELPNHSDVANDDDGINASSWNTFWKSKENNCDKKSKRLMNASVIKSMKSVLLSPCPDAKFFSDPDARVATIIHDKIYTEKNLPPPSPTLYEGTAAKEGETRKTRKEMEEIIARRWHKGMHWRKVVVLLKPDAHNNIIVRRRFSNAYGWPVVDHLVTAHFQRDDPIASPMQDKQFAEEDINMATGGVEPNKFYSWLTKIEDPSVYHGGIVSTASQLASSWISKHSSVTD
The following text describes a protein:
Function:
No glycosyltransferase or deubiquitinase activity is detected for this potential multifunctional enzyme.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MDEYLHSSGLYRKLTPRDASCLFRAISEQLFCSQVHHLEIRKACVAFMRENQRSFESYVEGSFEKYLERLGDPKESAGQLELRALSLIYNRDFILYRHPGKPPTYVTDNGYENKIMLCCSSNGHYDSVYTKQFQTDAAICQAVLYEILYKDVFVVDGEDLKTALDTFRGNGRKNRNSISPGNEDRMEDWGLSISSGHEQQQLDRYRHGIEEGKFSDNHSKMPFPYKVMKALDPDIYRNVEFDIWLDSRKVLQKSDYMVFAGRQYFLGDKCQVRLEPGGRYYNAHIQEVGNNPTSATVFIEELAEKHVVPLANLKPVTQVTPVPAWNVVPSRKGGSSGGSGGGTYPKIPGAYAPDMDLDVKGRKRMLKKVRGKEVFMTVAYSRGEPMLPPRLQHSLHTSRSSSVHCTPPNAGAMMAYDHLRPQPPPPPPLPPPPPPRHSRGFGIPRGGGGAPRFMNRHSVAPPEMAFYPGPGKRCYQSYDNFSFRSRSYSRSRRQMHCVNKECQYSFAPEPGATPRGLEETITYYEIEEGDETAYPAIGPQNTPSPMVSPTAAAAAAAAAAAAAAAAAAGFWVGRQGPNPMASGKPAVTSSEEEVEEPSDSSDYHHNYLYPTEPDYETPSVYSTTESTANLTLQDGRPCSLSPPDTAAYTYSQKMLMSPPGVSPTSCGSSMPPAVLPSCSSNQTAAATATAVASVSPQASMQPFFMAPASLNRPAIPSATFSYYPSPVAAAAPPSEMGESGGIPVPPPYSYDPNGSDLPRDTKVLQYYFNLGLQFYHQSYWHSMVYMPHLQQQQQQPQQPLPPPPPAVPAQHMEAYPVYPEHVAVVDHVGSQVYNDMGRADNQQVSSETAAGSIYSNSEQPPPPTGPVYYPVMPDPYGQQPMQGYDPYVSMVPAYHYLTPWHQTGAYGNSPRIHGALNSGPMPNAQVSYVPSASSTASAHYSPPNM
The following text describes a protein:
Function:
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Subcellular Localization:
Secreted.
Sequence:
MRNSVALSQPGILLLLVTCPLLTILQGVTCKAESGHLGDNDPDRCMRHHFVETITHPIYKCNSKMVLLARCEGHCSHTSRSDPLISFSSVLKQPFKNTCFCCRPHTSKLKAVRLRCSGGTRITATYRYILACSCEECS
The following text describes a protein:
Function:
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGNCVPESQDLKEMGEEELWEMINDNRHRISLGVRPCILIPYLRQARVLTDLDEDEIVSCHNLTNRCMRTSYMLDLLRAQGRNGAIAFLEGLMIHYPTLYTQVTGRKPSTEPSTFSGLIKYSELTEYLIRAVTGMQKELQEARGEAGRMSARCASLESEMGQMMEQEEKSGRLQSENDRLQRHLSSLQREVAKLKDEKCDLYIRYTTAIEERSAINERLHDLNLQVYQLQTELQNAQMDTKRHPLRFVSAPESPQLQEEVRTLRSQLAKAQTLDPARQDILAQDLAEAIDSQVQLAEQLRCYREENEILQRDKQALLDQKESLSLQVQQLTVDCKMLQQKSTLIQSQIKELQTERDQAYLSREEAQATIAQILAEKDALRSQLVVMQESVFTLQVKRRSSVKQKVKDVRWQSSVSSCDGCPRPERRKLCRMDALRPETFSNSEEEDAVMNSMRSRNAEPPGPESLRRREEILYADSSTESAETDPLLDDFVLLTDGSEDRNELESPSLSNSESSGSSRKSAPPFLVRSRPKAIRVIGRVISISFLGEALLSQLTVVGGNKSGVFVHQVTEGSAAQGVGISPGAQIVEVKYEHNQRALRMVLEDSTLEEAMWALSQVTGFCHLSLRPRPDEYEALLQQLQKSETASGDSFYIRVNVSLPAGSTGTLAVTCNDILHVTNTRPSGAEDQWHACQVHPCQLLDLQSGTIPNYYRAQRLLIRTIEEINFQTKKCQKAGREVCWRKEKAVRIVSTGRQGRNPMWVSVEDKNSESTESGTPSSSKCCVTLMPYTLVTPHYPPICRPVLLLPSILGRILDKKLAGWQGFELCEAEVLMSSEHAARLQRSEILEESEQGRCYTLQSVERVMKKGTHCVLPLGLDCVRRLHRFQIFPIIIFIGQTSRSARKLRSKLQRHSQSEEQLLACSRSEEPLLDKLSCLYRSMAPDSWCDQTSLLTSLRTVIWEEQRKIVWVEPDLW
The following text describes a protein:
Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells.
Sequence:
MSERSPSTSGTFHRSSAHNTSSSEADVLSQSSDASVRKVRRREKNRVAAQRSRKKQTQKADKLHEEYECLEQENSSLKKEIGKLTDEVKHLSQILKDHEQICPYLHCPVNYVTVPRVTDAVPGCLPR
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
MGLNLSNGQKSQEGQTLDVASDDKILKHMKDVIRGKNGLDIQREDEDDPFFVVDLADIEMKHKLWKREFPNVQPFYAVKCNADRRVVETLANLGAGFDCASKTELRQVLDMGVHPDRIIYANPCKAISHLRFAKKNDVRLMTFDNEEEIIKIKQVFPTARLVLRIWAEDKTAVIPLSVKFGCPLHEVRRLLEAAKNLDLAVEGICFHVGSGSGNPESYYAAIRDARTAYDIGNDIGHDLRIIDIGGGFPGKSHHPSLSKSYLKFSAAARSAIAEYFPDSNNQNPRIIGEPGTFYVESAFSLAVCVIGKRDLIKNPFSAPKDENWNDIKDISATPEVAYYISNNVYSTLGDSFLIGAKFDAKVLKSSNNDGSERPSVLWGNTTSRVDCVRRHCLLPELEEGDWLVFRDMGAYAVAISSEYSGFKLPVCYSVPPRTNEQVKKAKNHGGHCRAGVSNEIH
The following text describes a protein:
Function:
Probably a thiamine precursor-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKLMDNKNIKKLTLLAIWTALTFVLGRLFTFPIPGSAGNILTLLDVGIYTAVFLFGKREAAIIGGFAAFLLDLTAGFSNYMFFSLIIHGGQGYLAGLTRYKWLNFLLSLLVMVGGYFIVGGLMYGWGSAIAGLWVNIVQVIVGFVLAKVLSPLIERTGILNGFRKA
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MQKQHQRQHKVELVANLKSQFADAKALLICDYKGLSVRKLEALRNKARNQGIKVQVIKNTLAHIAMKETGYSDLDLKETNVFLWGGDQIALSKLVFDFQKEHKDHFVLKAGLFDKESVSVAHVEAVSKLPSKEELMGMLLSVWTAPARYFVTGLDNLRKAKEEN
The following text describes a protein:
Function:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
Sequence:
MFRSKRRATERKNWGVAPSSMPAEIIYPSRMSFYNTPPNLGISLEAFEEWAIDRLRVLTKLQQLQLSGKTGLKDLDSGLKPTLEKYLPLGSSRNVSDEVTQKQRQKDHYSHFILRLVYCRTPELRKEFVEREKLLFRYRLSLEEGGERDSFVNSLDFEWEKVDVDEFEDLRPYLETVSRDKADIASRDYVKVDWQKVADLVDSRRVFLRAGKVYVPASLQQNLVVNEFESRLAVAMETAAMLLSRLDESTRLMPILDHLAQFGVTETFQKNEALDGKIGPSNIDSVVKHMPLCMSQLHTTLRQKNHLKHDGRFQYGLFIKGLGFSVDEALQFWREAFKVTDDKFNKEYQYNILHNYGLKGSGKNYAPKDCKSIIANNPPANSELVHGCPYRSLRPEELVGRLKNMGIEDRMELNKITDQVKNTNYHGACTRVLELTHPGLKVEEVVQHPNDYFLKGYGWQNGLEVAYTK
The following text describes a protein:
Function:
May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLFVYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKKTM
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFATSILRSAYPAYKSPYGPKYQYQPHIDGITPKQLVRILPTAAAWTGVALFAVVYYASGIPRLRRDVLQRIPYLGERYFVNEIPASDNPF
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLRFPHVCGLCLLLKYWQILALAPFRTSEPMVARCQRWMTLIAVFRWLLLTSMAPFVLWKSAAMYEATNVRHSMVFKTIALATMTGDVCISLALLGNHLWNRRELANLVNDLARLHRRRRLSWWSTLFLWLKLLLSLYDLLCSVPFLKGAGGRLPWSQLVAYGVQLYFQHVASVYGNGIFGGILLMLECYNQLEREEPTNLARLLQKEYSWLRLIQRFVKLFQLGIFLLVLGSFVNIMVNIYAFMSYYVSLHGVPLTISNNCLVLAIQLYAVILAAHLCQVRSAKLRKKCLQLEYVPEGLTQEQAMASTPFPVLTPTGNVKFRILGVFILDNSFWLFLVSYAMNFIVVILQTSFEHINHGEI