lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Lipid droplet. Note=Translocates to the nucleus when sumoylated (By similarity). RSAD2/viperin recruits it to the lipid droplet.
Domain:
The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation (By similarity).
Sequence:
MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSEQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPVVPPSTAAPRPSSISAGSEAGDWSPRKLQSSASTFLSPAFPGSQTHSESELLQVPLPVSLGPPLPSSAPSSTKSSPESPVSGLQRAHPSPFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEAGVTLKSTQPTLWVGVATDAWAAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRRAKKRPPMTQVYKRLEGLQAGPPWELEVAGHGSPSPQENSYMSTTGSAQSGDEPWQPLVVTTRAPAQAAQQLQRSPNQPVESDESVPGLSATLHSWHLTPGSHPSPASFREASCTQGGTTRESSVRSSPGFQPTTMEGSPTGSSSLLSSEPPQIIINPARQKMVQKLALYEEGVLDSLQLLSSGFFPGLDLEPEKSQGPEESDEFQS
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Sequence:
MKLYKFSTSHIVFGNKARQRLLQGVSEVKKAGVLTLGPQGRNVVIESETGNHRSTKDGVTVVKNVMMSDRLSEMGAAMIRQSSSQTNKFAGDGTTTSALIAANIFEMGQAYVSAGHNPIYITRGLKEAKNRVLEYLEEIKTTEIDDQLLYNVAKVSSNYDENLTNIVFKAIKEIGINGIVTIEPGGTESVIQIQQGIQILRGFMHEKFADKGTIKCILHYPFILTSKEPILQIKQILPILELVKNTNSPLFIMASDISEEVMSQLLYNHTKDIIKVCAITIPGMGQSFSNDLIDDFSILCNSQSVENVEGVKQLSQLGRAVKIEVSNTETMIIGTQPDEQEVENRKNFLKNQMENANNYSAQTLKDRLTRFDGRTAIVYIGGKSEIEMHENRDKLVDSLNATKSTLKNGVLPGGGTALLHASKLLDYLQIDPEYQLGVSLLQETLRQPIKQLCRNAGINDGQIVKVLLEEGDYNVGFDQRRACLGNMIDLGVIDSFAVVKHSLLDGVSLGSMLLSTEAAIVLDKNYTPTALNKYKKEAF
The following text describes a protein:
Function:
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MARPEQVLVLEPQHELKFRGPFTDVVTATLKLTNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGTSINVSVMLQPFEYDPNEKSKHKFMVQSVLVPYDMTDMEGVWKEAKPEELMDSKLRCAFEMPLENDKTHEGESKKNETPSTSVKSEHPAKQGSVSMDDGEVKKIMEECKRLQMEVQRLREENKQIKEDDGLRKRRVTSAAAPHSSNMAMTAVKDEGLSTRVLAFCLLFFVIGVIIGKMVL
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity. Enables the organism to utilize D-amino acids as a source of nutrients (By similarity). Unusually, has high activity on D-glutamate.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MATNNIVVLGAGVSGLTTAWLLSKDPSNKITVAAKHMPGDYDIEYCSPWAGANYLPVGAENSRVGQWERATWPHLRDIAQNHPEAGIHFQDTVVYNRTKDQGSTTGQWFSELVKPNPWYGKVLPNFRELSKDELPPGIDNANRFTSVCINTAVYLPWLVGQCRKNGVVFKRAVFKHVAEAANAHHSGQKADLVVNCTGLSSRKLGGVQDNTLLPARGQIVVVRNDPGLMCSISGTDDGDDEVTYMMTRAAGGGTILGGTYQKHNWDSLPDPNLAVRIMKRCIELCPSLVAPGQGIEGLDIIRHGVGLRPVREDGPRIEKELIDGVWVVHNYGHGGYGYQTSFGCATTAVEVVREALQQQKQRRDKARL
The following text describes a protein:
Function:
Plays a role as a bridging molecule that mediates recognition and engulfment of apoptotic cells by cross-linking the surface-exposed phosphatidylserine with the extracellular domain of the phagocyte receptor ced-1. Important for the generation of extracellular phosphatidylserine vesicles that promote loss of the exoplasmic leaflet from apoptotic cells in a time-dependent manner. Required for the exposure of exoplasmic leaflet on the phagocytic cells surrounding the apoptotic cells. Does not affect the phosphatidylserine externalization in living cells. May play a role in mediating transfer of phosphatidylserine from phosphatidylserine vesicles to ced-1 bearing phagocytes or alternatively result in the activation of a phosphatidylserine transporter in the phagocyte that promotes phosphatidylserine externalization.
Subcellular Localization:
Secreted. Cell surface. Note=Detected almost exclusively on the surface of apoptotic cells. In some embryos, also observed on surface of cells adjacent to dying cells.
Sequence:
MSRFLIYFLPFFIYSGNVLSKTSCLMATGVLKCPTDPEAVKKVHIDLWDEDSLPLESDDLMGRTWSDRNGNFQVTGCASDFGPINTPDPYLYIQHNCPHRDSNATNPIQIDVIPLFLPSIVRLGNVYLDRYLEDY
The following text describes a protein:
Function:
Component of the TRAPP II complex. TRAPP II seems to play a role in intra-Golgi transport (By similarity).
Subcellular Localization:
Golgi apparatus, cis-Golgi network.
Sequence:
MEFDFFSFVAPSRVQSLVLPFGRVRRKSFSSYLQLLRRVSHIQLSDVPVATATRKSSSFNPLAFPLGRLVYNFLTSLDDQQALLEEFEYFRRVFVLIGIVDGSEEQEVEQLCSTLDVWRRRIPHALVAKCIVFNCPEDKENIFNAPNIIIGPRSDFSINSVMRSILCDITAELLEGFSSLEFSIHARSVILSPITDMPHLAPLQRKNSNASIHSLGSSSRPTLTRTPSITSRSVNSVTERSKSLSKGRIENQFGQLYLLAGRVPNALKHFSTAIALSKATGDFLWQGLSLELFTVCLVIMAHLHVDVQIPPNILSMFPSYNDRLNAFGPLKFDALLNFITEMRNVVDQLYQKSTLQPNDAVPGLCFSESILRYAHLLTVVYSCKGFNDNALDHIIAQAPIRPVKKATTYVPNKATICQWIMRAQGQHLNSLSIRERCRIYGAMANMLGSIGFSRLRVKMLRELVASLTPVLLETRRQNASKNGIHPEVIASHTAQSFKSTHYCNILPLISEICQEYGLLKTDGSLLNPELTKWGWSNLQFDVLNELISLCDSLSDYRSILLLISLFFLTSVQTASSSQQISMFKAFRKTYLFASNAGIHINAPYWDPFMITDLKFIGSSENAELIHQRLRNGLPKSIEKGPFIYNPFNRRQDQNQSKSVLVVDEQVAFSIYFRNPLSVSVEVQDVHLETKGVSAKCSHSTFTMRPLSIERTTLTVTPTETGELHIVGCRVKVFGCEPILQYVYEAKDKHKSLHVYLEKSKDVNAELRSLDTIDHLWTYFPFKKDLKTKSFDCIVIASQPKLSLAFQNLTSGKFNFAEYETGELVYVIENTSFVEASHISVLFEDSSSKAFEQAIADKSITADRLYELQFEEFNLPTFTVESSQPFSLSPGERREIHIKIRAKPNSQEGLILFESSVHKPEDTEFYVRRLRIPVSLNISKRVDLKQWSAFMDTEGDPSYCLVLLNFYNHFSEPLFVTVKTASTDESRSVLIKPKADNVILFRLKRFIMSSEEINLDIPNLSTKQFVLSSGFKKSIEDSYTMKKRFWIKEYFLKEVQASWKTDDNLHHGEIYLRNHILSDEMANNLSILPIRIQAWVSYDSEKVTTVCPREPFKLVLEFFGHADTNMRYKISWTQLNTQANTSSFNGLILDGPEEDIVCFNNSKCHVVIERNMFAYTTGMYNIFVRIFNEELQLLSQPVDLDEPILLIVDAK
The following text describes a protein:
Function:
Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MPRHCSAAGCCTRDTRETRNRGISFHRLPKKDNPRRGLWLANCQRLDPSGQGLWDPASEYIYFCSKHFEEDCFELVGISGYHRLKEGAVPTIFESFSKLRRTTKTKGHSYPPGPAEVSRLRRCRKRCSEGRGPTTPFSPPPPADVTCFPVEEASAPATLPASPAGRLEPGLSSPFSDLLGPLGAQADEAGCSAQPSPERQPSPLEPRPVSPSAYMLRLPPPAGAYIQNEHSYQVGSALLWKRRAEAALDALDKAQRQLQACKRREQRLRLRLTKLQQERAREKRAQADARQTLKEHVQDFAMQLSSSMA
The following text describes a protein:
Function:
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Subcellular Localization:
Secreted.
Sequence:
MWYFCDVFGRIWQPPFILFYLSAFWIAPAILHPQCLDFKPPFQPQQELQFCQMYKNFGCCDYARDQELMKKYYRVMDNFDYYGYSNCASYVQDLLCQECSPYAAHLFDAEDPSTPLRTIPGLCPDYCAQFHSKCRSFLTLLSDDPRLAELEHDQRKLCQYLELDDPDYCYPHLLSNEHLNKNLGRTAADSEGCLQLCLEEVANGLRNPLAMVHANDGTHRFFVAEQVGLVWVYLPDQSKLEKPFLNITKAVLTSPWEGDERGFLGLTFHPRFKYNGKLYVYYSVEVGFDERIRISEFRISSTDMNVVDHTSERIILEIDEPASNHNGGQLLFADDGYLYIFTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDDNERGPLYRIPADNPFVHEPKARPEVYAYGVRNMWRCSVDRGDPITKEGRGRIFCGDVGQNKYEEVDIVEKGRNYGWRAKEGFSCYDKKLCANSSLDDVLPIYAYPHKMGKSVTGGYVYRGCENPNLNGLYIFGDFMSGRLMSLKENRQTGNWEYNEICMGIGLTCSFPGLINNYYPYIISFAEDEAGELYFMSTEIPSATSPTGVVYKIVDPSRRAPPGKCHYEPHSVRVKSNIIPFEPKERVHIPTKQPKLSNTEEPPLVTTKDWLRELLDNFREEDGQITTTPFTPTTPKPVRTSRQRKGRRRKGKHKNGAVRLVGDEEGQRDRGRVEVYANGEWGTVCDDLWNTKNAVVVCRQLGFLHALKAAKHAEFGEGTGLKIILDDVQCEGTEETLLDCQHAGIGTHNCAHYEDAGVVCGNSVASLQ
The following text describes a protein:
Function:
Has a role in pre-mRNA splicing.
Sequence:
MSSQPFWDERIHRWRCLGSEGNELIYIDEEQTWKDYDPNSLKMNKAGSTGAEVSDVTAEATEGKESSNGEDRHTKRLYESTSAEGYPSGSRNKKSKSENSEASPAPVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKNIDNGTPRIKIYRTEDGTPKGDALIVFFRSESVELAEQLFDDTEFRYGSGQKMRVQKANIDYKKEKTVNKDVGGALKKKALRLRQQQMQQISSWDDVDEEVDDKRKKRFNKIVVLKHIFTLEELDKTPELLIDLKDDITEEAEKCGRVTNVVLYDKEPDGVVTVRFSNNEEAEACVRLMQGRYFDGRVVEASIYDGKVRFQKSGKHTLDDEEDEEKRLEKFADWLENSN
The following text describes a protein:
Function:
Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDPAPGVLDPRAAPPALLGTPQAEVLEDVLREQFGPLPQLAAVCRLKRLPSGGYSSTENLQLVLERRRVANAKERERIKNLNRGFARLKALVPFLPQSRKPSKVDILKGATEYIQVLSDLLEGAKDSKKQDPDEQSYSNNSSESHTSSARQLSRNITQHISCAFGLKNEEEGPWADGGSGEPAHACRHSVMSTTEIISPTRSLDRFPEVELLSHRLPQV
The following text describes a protein:
Function:
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MDRIRLFFLFIAIILYILSYPPFNISFLIFFTLVPLFSLLPKFSTKEAFIYGFLYGFGFYGVNFYWIPDLVSKFANLGVGIFANLLLISYLSSYYGIFLWGCKKKENSILFPAFFMVLLQWIRSHGPLAFNWGSLGEPMVNILPILQWASVLGELGLSFFVVLVNSLISRWKNLKFIRKTAFALSLVLIFLIGFLMMGESEGKYKVGAVQGNYDSFSKYFYTDIYDQFKVHRDLALKLPDNLDLMVFAESVLFCYLNEYPQYLISLRELSEKKNTPVLIGALEKREDKIYNSAYLITQDGKYITHKKSQLVPFVEEVPFPFNFIIPEYFKGLIGNYNRGPGFTPLPLKEKFIGVLICFESLFSDLARELSQKGSNFLVVITNDGWFEGTPAVYQHRNQSLLRAVENRISLVQVANTGITFFVDPFGRVLKESREGERNVYVANLPKKIFSIYTIWGDLPIFIGFIIFLLIKLIIE
The following text describes a protein:
Function:
Part of a binding-protein-dependent transport system for a sugar.
Subcellular Localization:
Periplasm.
Sequence:
MNAIRRLSAVICLSSLCLSPLLAQAGEVEVLHWWTSAGEKRAAETLKKLVEAKGHTWKDFAVAGGGGEAAMTVLKTRAVSGNPPAAAQIKGPDIQEWGELGLLADLNAVAAEGKWDSLLPKQVAQIMKYDGDYVAVPINVHRVNWLYINPEVFKKAGATPPTTLDELFVAADKLKAAGFTPLAHGSQPWQDGTVFENLVLSKMGPEGYRKAFVEQDKATLTGAQMVEVFAALKKLRGYVDADAAGREWSAATAMVINGKAGMQIMGDWAKSEFTAAGKVPGKDYQCLPFPGTQKAFDYNIDSLVMFKLSNAENRKAQEDLARSVLDPSFQKDFNLNKGSIPVRLDADMAPFDSCAQQSMKDFKQASQDGNLVPSMAHSMAASSYVQGAIFDVVTNFFNDPAADPQKAAQQLAAAIEAAAQ
The following text describes a protein:
Function:
Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively.
Subcellular Localization:
Mitochondrion.
Sequence:
MARPAPRYYSDSDTDGTSSHDYGYNLTAEEEEEISALIDSISPPTPPIPGPGTRTLPQNTAATPFGSSASPRSPPKYSTTVVADAAFVDFLAEDEDDVSDPSFDIRSIDNAVHRHVAKPDPSERACIIPSPDVPSSDSKSRLAPSVRDDNPRLATFVADSNAKPVHSDPTDSDVHYPDLSNALSGLQQQEPSGSPSNTPASKAGTPRKRGRPKRSAEEKGLLIEDNRSPILRFRTFPKKPFSVSDLTSGAWCELQYYFVLSKLPGGKKTRTQAMKGGTSIHEKLEREIYTPVSVEITKPEDNFGLKIWNIITGLRTLRDTGLTRELEVWGILDDGLVVNGVIDGLSYDNPDPTLEEEVLSSRSSQVTDKPLSQQQQHEITDFFPPEVADKREIFITDVKTRGSKKPPTKAAMRVTIIQLFLYHRFLSEMASGKLNYWRIFERYGIDPDEPFSDTFMAQMGALHEEVFSDTTSDGAGLDYVSAVSTTSDGASETVSRDDDLESTVSSTNAFDSLRYRTLRDLVSLLKFELQLTFPRGGASLGQIVAVEFRYRSPRPRENKEEEEEEEEEEDPENGSVICVNSFYVEPETLDMYLQDDLQWWKGERDPRGVPVEESYKCQMCEFAGECDWRMRLEQETMRMAKKKSLARNKNKEPSVSW
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MAATSPHLTSIPQAVRVAASIDPSIDPGLKQQAIDYLTKVKQLSEETWQDCLQLYLQGAGAPGPSTTGRDGKEKLETDMRMFCLQVVDTVLIQKPEVMGADAVQGMYEAIVEFIQVEYIGGSCEGGQGFLRNKLAFTISQLFLRAFPSHIPTFLHPFFALLSPPTSSPPNLHPQLLTIRLLLEIAQEIHDTTLKTARIMTKERQERDGVVRDVIRSSGDDKTAVQGMLGIIEKGLEQMNSGNSSDKWAEAVDATLKTLSAWIPWIDLGVALNPTTLPFYHRLLHQPILSFRTATAGIYRTLVAKGIQDPSSRLQVLRVLAPVAVIDPLETETRGGKSEEVATFRASLGVVLSAYGVALIGISDNTEVAEQLRNEAEEMMNPALPLLLRFLSDRQYEVPLSVSPFVSDLLRIYKRMYKPPNPSTKAGQAPSPPSTLPQLSPERRQFLASMLDILIRQLAWPEDTEWEAPGNEDELDEDIAAFKNFRGSCRSFIESIAQIDKSLHTEVVARIVIATLDAYASGGGAAAVPWQQAELAMHLVYTFGEVSKNSTRAAFYELPPEMATKAARNKLRAAQGSGRTTPSSSDNVDLGPSSNNDRLEYEQFPLSPLGQLLTRCMTSGISSYPHPSVTLQYFEIIVRYIEFWKAKPETLPGLFEALLDGQGIHNSDEGVRRRCFYLFSKLCKDCRNDTVEGMVSPILDSMRDMMVINAELPPTDTPDEDPLIKATTGKSYVADQLYLFEASGNLVYLTKADPAKQMALLEAVAGPLLSGLGSGVERARVDENDLQAVLQVHHHLMALGHFAKGFPIVPDKLVELLPYTGPFKQMAEALLQAIEILKRRRVVRDAARFAFSQFANAIGTPVAELVPRFVSAVVTEFEPSELVDFLLFLQLLMHRLQGSTFETMDMLLLPLLSRIFTVLQQPVTGTDEAQVHARLKDAYLAFFTSLMNENLDGIFITDRNKPEFENVLTTLFNLTQDYSDGASQRLAFGFFSRSVIAWGTSPEAAARPSVFAESAMASQSKMVSGGGTAQPNAHAVTQEQRAKQCLPGYENFIYQRLLPAAFEVPANSQFNIRGGQLIVHEAAVLVRNTVQARGQEAIDFMLSDLLRRLNCPSDIANQLIASLTTQQAKDFKKTFFDFIKAMRG
The following text describes a protein:
Function:
Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle around the centrosome at prophase and prometaphase and at the spindle poles at metaphase and anaphase.
Sequence:
MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPLPDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDARLQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDFSSFLEVRPDGHGGARLHTVDGHWVAPVPRLPFEVLLRMLYPRVWPYRMKVPQGFYPISMREVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPTLPSPQTNP
The following text describes a protein:
Function:
Part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE. Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4. The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide. Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol. Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation. Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional.
Miscellaneous:
MISCELLANEOUS: In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.
Sequence:
MVMTNILCQILSDDLPELPPCREPSKGMIVGNLGMTSNTMTTEGPFAKLDVESVLSFMSPSCTLRSFPSSLGKPALQTKEESKADFQGLKDFFYNFQLRVKDGAEPVIDEPARKVVLHIEGKGDSLVGRFETEYVYILQINEEGTMVEDFFQFADSATRDAWGKKIEAHFSARN
The following text describes a protein:
Function:
Netrins control guidance of CNS commissural axons and peripheral motor axons.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MPTWPWGLLLTAGTLSAALSPGLPASADPCYDEAREPRCCTPGLVNAALGREVLASSTCGRPANHVCDPSDPQRAHSADLLTSAPGTASPLCWRSDVLQRAPFNVTLTVPLGKAFELVFVSLRFCSAPPTSVALLKSQDHGRSWVPLGFFSSSCSLDYGRLPAPADGPAGPGPEALCFPAPQAQPDGGGLLAFSVQDGSPQGLDLDNSPVLQDWVTATDIRIVLTRPAIQGDTRDGGVTVPYSYSATELQVGGRCKCNGHSSRCLMDTHGHLVCDCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPVPGPTEESSPVEPQDCESHCRPARGSYRISLKKFCRKDYAVQVAVGARGEARGAWTRFPVAVLAVFRSGEERARRGSSALWVPTLDAACGCPRLQPGRRYLLLGDGPGAAAGSPAGRGPGLSAARGSLVLPWRDAWTRRLRRLQRRERRGRCGTA
The following text describes a protein:
Function:
Negative regulator of late steps of the endocytic pathway.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Note=Post-lysosome.
Domain:
The coiled-coil region is essential for oligomerization and binding to vacuolar structures.
Sequence:
MIESSSFMKKTSSENSIGSRSNIHEASTFSSEHENGDQSLTISQIVIRSDFANETSERQSKIILERFNEGIKNTAFTDSPVLGRAQPRLDVSYFAMAHRNQIVELFDPRGQRFGTVYSADPTVEIRYLGSVAKTCRYFGSFGKHVLNVPSGHFAKAMTKNRPIIYGEGPHVIIDPTFEFDERYGFVNQQEPFINHSTINILRVPSGKVAKVWIGTQPLILESRREPYVFVDAQFKMVEDTSESGNNKYFKNSSATFMEHGSIKRIIPHTGEVAITYNNGILTIIPPPKDGKPVIIDSPTHNFEGFIQTSLQTCLFPSKETKQQAIKDNKNATSDEVNLKIFQTRDSLRVGVVLVVAFRIVDPEIALTKLGKEGIINHIENVSFADMGKAIQLSTLQEIMYFNDTKPSANSTNETVHTIQDRVKSHLARDLCEYGIELARLQIETMKVLDSEIAKKLAGQSVTSAEFTTKQATLVKEYDIKTTEARLKAETDNIALEQKGKAIIAEAQAKLESAQKQAQALLITAEAQKKVQEMQGELFTKYPILAEIELAKIKSEALKSATLYITPQDAGNFMNSPLVYMDRLLGHQQKLEK
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MNQASFGPLAKSQNQNFFRMPEEHSFTSILPSHNVDGTGKDRKQLCNLIGNTSLEDRGLKEFASSRMTTVKAERDAAVRERDMAIAEKKAATSERDSAFNQRDMALAQREEAVMERDAALAALESLKRDHPDWHAYVAQLAHIFSSTQLGSCVREARVDQPIENYAYNSNRADGQMGLSGPSQPVVAPTDGSNPDMGPTKNGEKRKGGAWDGKKPGRRNSATNPAKKRKPAAEKKVGIAQQNPKPTGQKRRERGSSLHKSLSMPVPYCSCTGANHICHRWGDGGWQSACCTPVMSVYPLPMNPYKKGYRLTGRKMSGGAFQKVLQRLGQQGVDVTKPIDLKDHWAKHGSNKYVMIK
The following text describes a protein:
Function:
May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MARQILSQSYVRPAPLGPLLLYKHPNGTAHLPSSSSKHLLSTQLPAAQATVAMARTMLLPVLLSFLILPFSALALTQDFCVADLSCSDTPAGYPCKAAGSVSSGDFYYHGLAAAGNTTNLIKAAVTPAFVGQFPGVNGLGISGARLDIAVGGVVPLHTHPAASELLFVVEGTVLAGFITSSSNTVYTKTLYKGDIMVFPQGLLHYQYNGGASAAVALVAFSGPNPGLQITDYALFANNLPSAVVETVTFLDDAQVKKLKAVLGGSG
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
METINYQQFSEKLPTLVEKIGNEQEPLCLELPNYLRAVIISEQDYRSLMETVYLLSNPVNAEKLLTTASRSIDQATSWTKVKNDLGL
The following text describes a protein:
Function:
DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MNLRSRLVNATERAVLFQIFKDVQNDPEKYDNAVEAICESIDYFGKFLTDSEYLTQIKPILDTQCPTKSIICFSKCLTKVSTDINTTTFRDVITMLDWLKYVVEKSLTSAICSSLKVKETDVSAVQLYREFASACSNIPEKVSNCCAKALSGEHVKYINTVKWIFKMNLVQGIQKAMLLAHDDIVTAAPFTSFYGSGGPYMKTVAEIISSGRNIDITNKDGLLVQMIEWIGSLNNFDSQWRRMMFLIFQEPTYQGIQVHESLLTTLFLISKSDQILKRCIEATDLTGTLKRVVMVKLPFQRVLKRKTIEILINFVYRTKEQFAIQLLETSVKIWSDLNYAKSAPESQERHIVRMILYLVHLFRTCSSIDWESLFLNSMDGVHCRMSMLPMYVQSGIFVNQALCKQATKHRSKTHGSDEQPPETLEENKFVSSEVGKIWFEEMTSILEHGFNSSTVKDSERVRETANEITKDDSGEEFEETNAQRLQNNKDSAAITSKNNLRLDSDDDEDFPDYQVNESEKIFKNLEIGEEPKNKVTPPAYIADAFEMLLEKEKYEVFEAAFFNITNLINRRPIGFPQIAEKLFIRILHLQNNFGTPKFKETVDEIAVACITQRPEIVPSVVRLIIAPGQGFSIKQRLLHYIHNAADGMGALDKKLEECVMAQQLRIGGPTLSIILHRTINTDYDDEDEDPHRLLVPEWRRMVDARIAANTRRIGTTREPPRAGVVNRLAQAAKYMFYPLLVLPRGENASLLGKDSDLLASLIMVASMVYVRCGVCPQIHRMSSELISYATPHRFSENAKLRTACIIAHLNVTTLLPGDLMDELFDVPALIGWFDWANSVLVNASSSQLEKDMTRQFGHSVTKHLQRYHPAVLQHQDV
The following text describes a protein:
Function:
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation.
Subcellular Localization:
Nucleus.
Sequence:
MGLLGLPPPPPPPPPPPPPQNPGLGGGGAAYGAPAPRSCQHCQCHRHATHRYPWDGVSTPPVMDPSVTLWQFLLQLLRQQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSHPEVAGCSTEDCAPQSEVSVTSAKPNAALAAVHAAPGDTASGKPGTPKDAGRAGPSGLAHSRRNEYMGSGLYSTFTIQSLQPQPPPHPRPAVMLPNAAPAGAAAPPSGSRSTSPSPFCLEAEEAGLPLQTILTPPEAPNLKSEGLNVEPGLGRALPPEVKVEGPKEELEVAGEGGFVPETTKAEPEIPPQEGVPARLPAVVMDTAKQAGGPAASSPEISQPQKGRKPQDLELPLSPSLLGGPGPERTPGSGTGSGLQVPGPALTPSLLPMHTLTPVLLTPSSLPPSIHLWSTLSPIAPRSPAKLSFQFPTSGSAQVHILSISVDGLSTPVVLSPGPRKP
The following text describes a protein:
Function:
Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling. Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA. Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity.
Subcellular Localization:
Secreted.
Sequence:
MALLGALVCCLLATWHSRRGLALPLAPTGGQSPPPVVGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYHLILSAFDFIKKSGQEASFMIWTGDSPPHVPVHELSTDRVINVIANMTTTVQRLFPDLQVFPALGNHDYWPQDQLPIVTSEVYNAVANLWKPWLDEEAISTLRKGGFYSQKVSTNLNLRIISLNTNLYYSPNVVTLNKTDPANQFEWLENTLNISQQKKEKVYIIAHVPVGYLPYSKSTTAMREYYNEKLIDIFRKYSDIIAGQFYGHTHRDSIMVLSDKKGNPINSLFVAPAVTPVKNVLEKLTNNPGIRLFQYDPRDYKLVNMLQYYLNLTDANLKGESNWKLEYNLTQTYDIEDLQPKNLYGLAKQFAILDSKQFIKYYSYFFVSYDTSVTCDETCKAFQICAIMYLDVISYTDCLKHYIKRNP