lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA. Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA. Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway. Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity); [Isoform 5]: Receptor for both IL17A and IL17F; [Isoform 6]: Does not bind IL17A or IL17F; [Isoform 7]: Does not bind IL17A or IL17F; [Isoform 8]: Receptor for both IL17A and IL17F.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced.
Sequence:
MPVPWFLLSLALGRSPVVLSLERLVGPQDATHCSPVSLEPWGDEERLRVQFLAQQSLSLAPVTAATARTALSGLSGADGRREERGRGKSWVCLSLGGSGNTEPQKKGLSCRLWDSDILCLPGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLPDCRGLEVWNSIPSCWALPWLNVSADGDNVHLVLNVSEEQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLQLLTLQSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPLKDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACPMDKYIHKRWALVWLACLLFAAALSLILLLKKDHAKGWLRLLKQDVRSGAAARGRAALLLYSADDSGFERLVGALASALCQLPLRVAVDLWSRRELSAQGPVAWFHAQRRQTLQEGGVVVLLFSPGAVALCSEWLQDGVSGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFDRLLHPDAVPALFRTVPVFTLPSQLPDFLGALQQPRAPRSGRLQERAEQVSRALQPALDSYFHPPGTPAPGRGVGPGAGPGAGDGT
The following text describes a protein:
Function:
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Sequence:
MDPFTLEPIGALSGHDDRVWNVAWSPQGDMLASCSGDKTVRIWSRRQPRPSEQVPSSASAVPQPPQPPQPPQSQPAQHQQQQLPPTQQQQQWYCSAILDQCHTRTIRSVAWSPTGRALATASFDATVAVWELSSGVWEQVAELEGHENEVKCVAWNPDGRLIATCGRDRSVWIWESMPGREFECVDVKQGHSQDVKAVTWHPSGELLVSAGYDDTIKLWTYDGDEWGCAQTLGGTGTGHESTVWDVCWDPVSRARLASCSDDLTLRLWESRAAPTSTPASAPAGAAAAVVPEGTVGGAGGPQGFVPSRPDLRCAVTLSGHHRRTVFSLDWAPTGLIATGDGDDSILVFGEGDPDMAQLLLRRREQQQQQQQRQPAVAAATTSDGDAAMSEAPAPEGQTAVQAGAEGVEAEEEASGLLTQPGGQWGCWARVAKAHGADVNCVRWNPAEPRLLASCSDDGLIRLWWLR
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of short and medium chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain.
Sequence:
MAARGGALLKYLRVSVKASPTTRNPNNNGLFGLSFNTICRRFSEEVRGTFLDKSEVSDRVVNVVKNFQKVDPSKVTPDAHFQNDLGLDSLDTVEIVMALEEEFKFEIPDNEADKISTVSLAIDFISSHPQAK
The following text describes a protein:
Function:
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Sequence:
MKGDSEKPIEVHFEDICAAEFRIRKGVKRTTCLKSNDISRMVGMEIFFKNEYLQHTGSFKERGALNTLLLLSKEQKRRGVIAASAGNHAQALAYHGNKLKIPVTVVMPENAPLVKQTMCREYGATIILKGHHLVESKEYALDLADQKGLAYINGYDHPHILSGQGTVGLEIIDQVYPLDAVIVPVGGGGLLAGIAIAVKTIYPHVKIIAAESERCASFKAAMEAGAPVKVEAHHSETLADGLCVPQVGSNAFANAKDLVNKVIVVSEDFIGLAILHLIELEKSVVEGAGATGLAAVLSGQLPELKGKR
The following text describes a protein:
Function:
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYATQPYLELRERLSQIWINRYTLLLMLCMVKILLFTSSLRFSLNNSKVHVLEECSNIEHYYNILRNGTPHYMGKMGNYLVAHALEATVESLLALLTSLATVVEVVAHFMIELWLGTYACLLFSAAHGAVEVATNVTEKVIGVANKTLIAAANELDNGLDGLSKVLNKIIETGTKVSHLFKDDDEEHASPEGQFKKINLTIASLRTVKIPESVNDKLRSLAEKTPDFEDVKNKTKGLVSIPFQTLKNEINGINATSMLKNRKLMSVPPIDMGDAADGVCSANRDGIESVYRNLNSALIYSLVATAVSLAIVALLCLIPAAWHEYRQWERLSALRDHERTVDCKDPFADTHSSASASTASSTRCDVIQNYQGVFHRAPTLIGEWVARHTAHTQEGALRIQWLLAYVLSPRALVPLALGLAGVLVCGCQFLIIHALRIQLASTSTRDSLQRLETDTAGLVAHDLSRWADSTNAYINGTEASVNAGLLGWVTTATTALNTTVAALLADIDSTVDRAFADTPLHRPMVTVVSCVIGNKLRAIEAGLTWTHDHVRIALPRIHTARLRDAVAEPDLPTHPAYTAVLQSLSDRLRHSVDRVLHQCCAAVRIELYVSLALLGLWILQTPLGLAMLLFKSHCRRRNLRRRVP
The following text describes a protein:
Function:
CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
Domain:
Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster is to be the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer.
Sequence:
MKNCIAAIPEVKEMVEKAKLKGIETPHTRFPNQFPKCPYGLKGVYCILCANGPCRITEKTPYGVCGATADVIVARNLCRAVAAGTSCYVHCAENAARALLSAGKGEGSYEIRNEKKLKFLAKKLGFDANKDAKQLAVEVAEFILDDMYKPRWEKSELVPKLCPEKRLEVFEKLDILPGGAKGEIVDALTKTSTNLNSNPMDLLVHCLRLGLHAGFTGLLMTCWLNDILFGSPKITVVENGFSSVKPNNVNIMITGHQHALIQPLCEAAMEEDLIKMAKEAGADEIKIIGATCNGQDMETRIAHLPESFVGYIANNFTTEPLVATGLIDAVVSEFNCTFHGLKFVAEKTKTKLICIDDMAYVEGAEYIPWEPENAKEKAREIIKKAIEAFKERKGMQKDYYDEKVKSVVGVGEESLVEFLGGSVKPLIELIASGKIKGVVGVVGCSNLASGGHDNIIVTLTKELIKRDILVLAGGCVNSPLKHAGLFDPASAELAGENLKEVCKSLGIPPVLNFGACLSIARIEQVAVAIAEELGVDIPDLPVAASAPQWLEEQALADATYAVDMGFTVHVSPVPFVTGSELVTKVLTEAVEGLTGGKLIPEPNPYKAADLLEQTIMEKRKKLGI
The following text describes a protein:
Function:
Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MDIEEWEQRHAEAFYNAKEALPYLDGMFVAYNSNIDAIRHLTEEDLSKLVGFFDESDIQDRVAAYPREIAEPLDFVARLLISMREGKAAEVPAYTADIHEWLKEHLGFDYARMGGQAGIISNLLGRLGLKKVVAYVPWLSEEQAEYFTATGNILHPKVENGKVLLKPPGEAFKPGIGSKVNWILEYSKDMNVTCAGNTFKVPRDNRLIISSRPKWLRLDMDKQIYEQLDTLLPVDGAMLSGYQMIKEEYEDGSTYKDYVENSVKVIEKLKSLNPELRIHVELTSIQNRLIRKAILTEIVARHVHSLGLDTVEVANALNVLGHEELSYSVIRKGENGIMSLYQGAVQLMKDLDLERVHVHSLGFYICILAKGHPLTLKEHRDSLLFSSVLAAAQALNGNIENLAEAEAGLEVPVSSIGLEDLENFQLYCTGRKLCTPDEFEYGYVYGSEHDAILIPSKVVERPKATVGIGDTISAGAFVAMLAKIKQKHSGK
The following text describes a protein:
Function:
Collaboratively with CYP40/SQN and ULT1, influences floral meristem (FM) determinacy in an AGAMOUS and SUPERMAN-dependent manner, thus contributing to the floral developmental homeostasis.
Miscellaneous:
MISCELLANEOUS: 'Rebelote' means once again in French.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Observed in the nucleolus of root cells in interphase and colocalizes with DNA in dividing root cells.
Sequence:
MGKLGKKARKFAKKNLQSVEKRSRKLKPFIKKKFAKRNERHQAGDKQEKKVEQQPKKRCQEEEFQDIAIDAVFGKDDDEVLRDGDSDSDGYLDELVNETDSDIMKCKVLSRSFLATCCDMVDKEQYVPALVRLLNWYRAACQYGHEPSGIARPNIYYDIEDSETFAKVIIFVLQKADHTFRSILGLSDSSTKEKILKLKNNPKWDSLKPLVKSFFRSTLHLVKQAGDLEIISFTLTQLRVSIVFLAAFPDLLKKLIKISVHLWVTGEETISQQAFLILKDISMVFNSECFDSCLINMYKAFLHDCDIPKANSEQRPFLRDSLVELCSQDVQKSYTKASVSITQLAKLLKMALATKNKEAVEKIHSGEYINCVDLWVNFISANVQDCDLQPLLYTIVQVINGVAQLIIGPRYLLLRVKCIHWLNHLSRTSGIFIPIASLVLDMLEYKTTNDGEKQEQKLEAVSTVKLPKNWLKSQNFQEQCIFSVIELLAVHFAQWSFHISFPDLATIPVMRLKKFHERSTMEGLKRVVKRFIEQVESNIEFVQRKRDDVTFSPNDQQSADTFMQLEKQNANAPYTQYYQSIIDKALGTNKKKKK
The following text describes a protein:
Function:
Required for the normal migration of longitudinal and peripheral glial cells. During larval development, required for the migration of the subretinal glia into the eye disk. During embryonic development, also controls the migration of muscle cells toward their attachment sites. Required in the mesoderm for the correct morphogenesis of embryonic gonad and for tracheal branch fusion during tracheal development. Shg may be cooperating with foi to mediate a common mechanism for gonad and tracheal morphogenesis. Acts as a zinc transporter in both yeast and mammalian cells.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MARHIMAVCVVCLLCAHRLHCQDHIESLLGPARVTTHNSQDQLNARVYTNLSPSSETTDRRQQRSASGDDDTFNYSISPPSRREKRHAGHEHGPTSESRVPQITQYYLEKLMAQDELMNSSGFDGLLQQLSLHSLASGASEGTCVPGSRLVHHVQPHDHHHAHHHEEEDHSLQLNNCTLIQNGTTSNVICPSLPNNNTHPLGKEAKNFTLSDKDLLHLCPILLYELKAQSGGCIEPAILSDIDTTEELLEAEKDKDIFYVWIYAFISVFACGILGLVGVAIIPFMGSRYYKYIIQYLVALAVGTMTGDALLHLLPHSLAGQDERGMIMKGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGAGGDAPSVAELRNGVGDHDGSNDMAAAAESLISPLHTNCVEMNHHNHNHKHNSHQQNHEGQDSNTIVTDLDGNAVYAVNKAKDKDSRNDHVTVILREHESSHHGHSHRHGHVHSPPETLSAVAWMIIMGDGLHNFTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQSQDVAQWMFAVAAGLFIYIALVDMMPEISASHKSLGQFLLQILGMLSGVGIMLLIALYEGDLMSAFGTAGAASHQHAH
The following text describes a protein:
Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MWRRIVSSQLKTLAADVVAASPRRSIAATTRPVGFYLAANRSAISASSFVIPRRFSSDSVETPATKKVEDVMPIATGHEKEELEAELEGRRLDDIDFPEGPFGTKEAPAIVKSYYDKRIVGCPGGEGEDEHDVVWFWLEKGKSFECPVCTQYFELEVVGPGGPPDGHGDEDDEHHH
The following text describes a protein:
Function:
Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes. Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and tumor antigenicity.
Subcellular Localization:
Lysosome.
Sequence:
MVAPGLVLGLVLPLILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQSQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLEKINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSAVCWLFGRHLYDTLQYPVGLIASSWGGTPIEAWSSGRSLKACGVPQQGSVPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINYNTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFGSIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCTDHRCKWLPASMNTVSTQSLTLAIDSCHGTVVALRYAWTTWPCEYKQCPLYHPSSALPAPPFIAFITDQGPGHQSNVAK
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLNISKIFEEVKVMKNFTLNFGPQHPAAHGVLRLIVELESENVVRVEPHIGLLHRGTEKLIEGKTYTQALPYFDRLDYVSMNVQEHAYSLAVERLYLDSLDIELEIPQRAKVIRVLFSEITRVLNHIMATTTHAMDVGALTPFLWAFEEREKLMEFYERVSGARMHAAYIRPGGVAFDLPMNISEDIYKFVIQYRKRLEEIEDMLINNRIWKQRLVDIGIVSAEEALNYGFTGPLLRGAGIVYDIRKNYPYDDYDKYDFKIIIGEENNSYTRFIIRMKEMYQSLSIIEQALNNLRPGLIKLEGVNITAPDRAFVKKDMESCINHFKFFSEGFIIPANENYTIVEAPKGEFGIYLNANDTAKPYRCRIKAPGFLHLQGLNMMSKDHLLADVVTLIGTQDIVFGEVDR
The following text describes a protein:
Function:
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Subcellular Localization:
Secreted.
Sequence:
MKVFVAICVLIGLASADYVVKNRHDMLAYRDECVKELAVPVDLVEKYQKWEYPNDAKTQCYIKCVFTKWGLFDVQSGFNVENIHQQLVGNHADHNEAFHASLAACVDKNEQGSNACEWAYRGATCLLKENLAQIQKSLAPKA
The following text describes a protein:
Function:
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.
Miscellaneous:
MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus speckle.
Domain:
RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence:
MAAATIVHDTSEAVELCPAYGLYLKPITKMTISVALPQLKQPGKSISNWEVMERLKGMVQNHQFSTLRISKSTMDFIRFEGEVENKSLVKSFLACLDGKTIKLSGFSDILKVRAAEFKIDFPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCKWFALKESGSEKPSEDVLVKVFEKFGEIRNVDIPMLDPYREEMTGRNFHTFSFGGHLNFEAYVQYREYMGFIQAMSALRGMKLMYKGEDGKAVACNIKVSFDSTKHLSDASIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRLQEAELRRVEEEKERALGLQRKERELRERLLSILLSKKPDDSHTHDELGVAHADLLQPVLDILQTVSSGCVSATTLHPLGGQPPAGAPKESPAHPEADGAPKSVNGSVAEEAPCKEVQSSCRVVPEDGSPEKRCPGGVLSCIPDNNQQPKGIPACEQNVSRKDTRSEQDKCNREPSKGRGRATGDGLADRHKRERSRARRASSREDGRPRKERRPHKKHAYKDDSPRRRSTSPDHTRSRRSHSKDRHRRERSRERRGSASRKHSRHRRRSERSRSRSPSRHRSTWNR
The following text describes a protein:
Function:
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Note=Localizes to cytoplasmic RNA granules (By similarity). Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity).
Sequence:
MLEADLVSKMLRAVLQSHKNGIALPRLQGEYRSLTGDWIPFKQLGYPTLEAYLRSVPAVVRIETSRSGEITCYAMACTETARIAQLVARQRSSKRKTGRQVNCQMRVKKTMPFFLEGKPKATLRQPGFSSDFSVSKKPNPTLLRDKGNSLGVKSDAEMPPYTLHTTLRSEVFKDVPVQRHVTMSTNNRVIPMCSHPDVDPLQYVGSVFKKHKYLRFSPKASLPPPFQMHLSRTCAKEMNGNLSQTVEKPNVTPPASYTYKMDEVQNRIKEILNKHNNGIWISKLPHFYKELYKEELNQGILQQFEHWPHICTVEKPGSGGQDLLLYPAKRKQLLRSELDGEKVPPSPLPAPKQIPPLKGCPAVMPGDFKEKVAELLTKYSSGLWASALPKAFEDMYKMKFPEDALKNLASLSDVCTIDYISGNPQKAILYAKLPLPTDKILKDAGQAHGDYDIKSMIEQEYLQIEENIAKSVDTFLENTAVPPLIIPTEASPSVLVVELSNTNEVVIRYVGKDYSAAQELMEDEMKEYYSKNPKVTPVQTVHVGQLLAVNAEEDAWLRAQIISTEENRIKVCYVDYGFSENIEKSKAYKLNPKFCSLSFQATKCKLAGLEVLSDDPDLVKVVESLTCGKIFAVEILEKADIPLVVLYDTSGDDDVNINATCLKAICDKSLEAHLQIDAMYTNVRVTNICSDGTLYCQVPCKGLNKLNDLLHKIEDYFHCKHMTSEYFVSLPFCGKVCLFHCKGKWLRVEITNVHSSRALDVQFLDSGTVTSVKVSELREIPPRFLQEIIVIPPQAIKCCLADLPQSIGMWTPDAVLWLRDSVLNCSDCSIKVTKVDETRGIAHIYLFTPKNFPDPHRSINRQITNADLWKHQKDVFLSAISSGTSSPNSKSGSTPVPGSTGDNFRKSLTDAIKKSVVDHTSSLSVEELPPPVHLSKPGEHMDVYVPVACHPGYFVIQPWQEIHKLEVLMEEMILYYSVSEERHVAVEKDQVYAAKVENKWHRVLLKGILTNGLVSVYELDYGKHELVNIRKVQPLAAVFRKLPFQAVTAQLAGVKCNQWSEEASMVFRNHVEKKPLVALVQTVIENANPWDRKVVVYLVDTSLPDTDIWIHDFMSEYLVELSKVN
The following text describes a protein:
Function:
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
MEPAVSLAVCALLFLLWVRVKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHRYGLFQHICTAYELVLADGSFVRCTPMENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYIKLRFEPVRGLEAICDKFTHESQQPENHFVEGLLYSLHEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLPQALHTFHNDIHVYPIWLCPFILPSQPGLVHPKGDEAELYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMDREEFWEMFDGSLYHRLRKQLGCQDAFPEVYDKICKAARH
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
Sequence:
MNLESTATSAEYWSDLADALNTPMMKQFLAIKKDFPDTILFFRMGDFYEMFLEDAKIASSILDIALTKRQNAVPMCGIPYHSKDNYISRLLNAGKKIAICEQSKPEEAGSKLMTRDVVRIITPGTVIEENLLSGFQNNYLAVLHLKKSLIYFAIADFSTGEVFYSSVSVTGLERLIAELEKFKPSEICVPKSEHTFFQELEYFKNREFTVLKNQIETSEKDSFQVLSKYLNEYIRETYRDNKLVLREPKILSSGKFLEMDRETIRNLELVENEKEKNNTLYSIFNFCNTAKGKRLLKQRILFPECDPVVLYSRWEKQDILLKTVLAPYITALKDFGDLERILTRFRGNHAYPRDFRSLLNSISSGIKLKEELEKVSYPFLIPIEELKKISDFIQERLHPGDDLPVILGNGIFLKKGFSQKLDQAREAGVKGKDWILDLETKEKKRTGLNTLKIRYNKIVGYFIEISRAQAEQAPKDYLKKQTLVGSERFTMPKLEEIERTILEADEIIQEIERTEFNRMVEEVLKFSSSLLSFSEEIGDLDFQISLLTAKDKFGWIRPKLSEDRSLDLSDSRHPVVEATLPPGQEFIPNSVYLDTQDKAIAVLTGPNMAGKSTFMRQIALNQILFQIGAFVPAKSAKLPIVDKLFTRIGAGDNLTAGESTFFVEMKETANILNHYTEDSLILFDEVGRGTSTYDGMSIAWSILEYLSSLSVRPKTIFATHYHELTELSRLGGIFNLYLETLEKEDRVLFLRKVKVGKAKKSFGIYVAKIAGVPEPIVKRAAELLTDLESKKKEIKIQEAQPTLFTEPETKNFNSQTEESILKLKLEEMTPIEALKTLEDFQKKLRKQK
The following text describes a protein:
Function:
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Subcellular Localization:
Cytoplasm.
Sequence:
MKNLLDLEHKLNYYFNDRNLLKNALLHKSLGNERKEYKNQTNERLELLGDAVLDLIVAEYLYKSYKNASEGPIAKLKAMIVSEPILAKISRQIGVGKFLMLSRGEVMSGGRNRESILADSFEAILGAVYIDSNLDEARVFALSHIKQYIDHIEENEDILDFKSILQEYVQKEFKTVPTYELVAERGPDHMKEFEIQVIVGNYKEKAVARNKKKAEQLSAKALCIKLGVKYNEAL
The following text describes a protein:
Function:
Autophagy-related protein required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG38 is required for the integrity of the active PI3-kinase complex I by maintaining an association between VPS15-VPS34 and ATG14-VPS30 subcomplexes.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localization to the preautophagosomal structure requires ATG14.
Domain:
The N-terminal region (residues 2-83) bridges the coiled-coil I regions of ATG14 and VPS30 in the base of complex I; The C-terminal region (residues 123-226) is involved in interactions with the PI3-kinase complex I, localization to the PAS and homodimerization.
Sequence:
MSTLAEVYTIIEDAEQECRKGDFTNAKAKYQEAIEVLGPQNENLSQNKLSSDVTQAIDLLKQDITAKIQELELLIEKQSSEENNIGMVNNNMLIGSVILNNKSPINGISNARNWDNPAYQDTLSPINDPLLMSILNRLQFNLNNDIQLKTEGGKNSKNSEMKINLRLEQFKKELVLYEQKKFKEYGMKIDEITKENKKLANEIGRLRERWDSLVESAKQRRDKQKN
The following text describes a protein:
Function:
Hydrolyzes various peptides including beta-endorphin, insulin B chain, dynorphin A, and neurokinin A, with high specificity for the cleavage of the Phe-Xaa bonds.
Subcellular Localization:
Secreted.
Sequence:
MKWVVLAFICLQLSEGLVRVPLKRYKSARDIMRERGILKEFMKTHKRDPALKYHFNEKYDFAVAYEPMYMDTYYYGEISIGTPPQNFLVLFDTGSSNLWVPSTSCQSEACSNHNLFNPSQSSTYTSNGQQFSMSYGSGSVTGVFGYDTVTVQGLSLNNQEFGLTYTESGSSFYYSKFDGIFGMAYPAMSAGGATTAMQGMLQQNLLTYPIFSVYMSSQSGEVIFGGVDNNLYSGQIQWSPVTQEVYWQIGIDEFLINGQATGWCSQGCQAIVDTGTSPLTIPQQYMGTLLQNLGAQNYNGMFVVNCNSVQNLPTITFVINGVQFPIPPSGYIVQTNGYCTVGVEETYLPSQNGQPLWILGDVFLRQYYSVYDMSNNRVGFAQAA
The following text describes a protein:
Function:
One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.
Sequence:
MKAKVIDAVSFSYILRTVGDFLSEANFIVTKEGIRVSGIDPSRVVFLDIFLPSSYFEGFEVSQEKEIIGFKLEDVNDILKRVLKDDTLILSSNESKLTLTFDGEFTRSFELPLIQVESTQPPSVNLEFPFKAQLLTITFADIIDELSDLGEVLNIHSKENKLYFEVIGDLSTAKVELSTDNGTLLEASGADVSSSYGMEYVANTTKMRRASDSMELYFGSQIPLKLRFKLPQEGYGDFYIAPRAD
The following text describes a protein:
Function:
Transcription factor (By similarity). Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Involved in regulating expression of vab-7. Appears to have partially redundant function to tbx-9.
Subcellular Localization:
Nucleus.
Sequence:
MTDQVYVTLREDQDKLWNLFHYHKNEMIVTKSGRKMFPKLEYVVRGLTPNKLYAMMLHIEPSDDHRYKFSSGEWVKSGKAEKHREPKKLWHADGVRSGKEWMTNPVCFDRVKITNCAESTNASMIFLHSMHKYTPVMSIYESPSESPFSVPQPSTRLVTSVRLTYTEFIAVTAYQNDAVIKLKIKFNPFAKGFREGSQSDRKRNSPSADDSTTDESSSQVSSPQPKKSRTVSVSPPLMPRILPTMIPPPPAINPLFYSLPYFSHLAATGNFPPVPFQFPFGLPCFSPMSFPTPPPSLKNVKKEEQEDIEQEINVV
The following text describes a protein:
Function:
Involved in the virus replication. Contains a helicase domain and a methyltransferase domain. The methyltransferase domain is probably involved in viral RNA capping. Involved in the formation of ER membrane spherular invaginations in which RNA replication complexes form.
Subcellular Localization:
Host endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MSSSIDLLKLIAEKGADSQSAQDIVDNQVAQQLSAQIEYAKRSKKINVRNKLSIEEADAFRDRYGGAFDLNLTQQYHAPHSLAGALRVAEHYDCLDSFPPEDPVIDFGGSWWHHFSRRDKRVHSCCPVLGVRDAARHEERMCRMRKILQESDDFDEVPNFCLNRAQDCDVQADWAICIHGGYDMGFQGLCDAMHSHGVRVLRGTVMFDGAMLFDREGFLPLLKCHWQRDGSGADEVIKFDFENESTLSYIHGWQDLGSFFTESVHCIDGTTYLLEREMLKCNIMTYKIIATNLRCPRETLRHCVWFEDISKYVGVSIPEDWSLNRWKCVRVAKTTVREVEEIAFRCFKESKEWTENMKAVASILSAKSSTVIINGQAIMAGERLDIEDYHLVAFALTLNLYQKYEKLTALRDGMEWKGWCHHFKTRFWWGGDSSRAKVGWLRTLASRFPLLRLDSYADSFKFLTRLSNVEEFEQDSVPISRLRTFWTEEDLFDRLEHEVQTAKTKRSKKKAKVPPAAEIPQEEFHDAPESSSPESVSDDVKPVTDVVPDAEVSVEVPTDPRGISRHGAMKEFVRYCKRLHNNSESNLRHLWDISGGRGSEIANKSIFETYHRIDDMVNVHLANGNWLYPKKYDYTVGYNEHGLGPKHADETYIVDKTCACSNLRDIAEASAKVSVPTCDISMVDGVAGCGKTTAIKDAFRMGEDLIVTANRKSAEDVRMALFPDTYNSKVALDVVRTADSAIMHGVPSCHRLLVDEAGLLHYGQLLVVAALSKCSQVLAFGDTEQISFKSRDAGFKLLHGNLQYDRRDVVHKTYRCPQDVIAAVNLLKRKCGNRDTKYQSWTSESKVSRSLTKRRITSGLQVTIDPNRTYLTMTQADKAALQTRAKDFPVSKDWIDGHIKTVHEAQGISVDNVTLVRLKSTKCDLFKHEEYCLVALTRHKKSFEYCFNGELAGDLIFNCVK
The following text describes a protein:
Function:
Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFRRLLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALGGLAAGLLLWGWQKMNQQRPHAPTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGREGAMILLAALAASSFARRFTPREEWKLWIASGAAAGMAGAYHAPLAGSLFIAEILFGTLMLASLGPVVVSAVVALLTTHVLNGSDSLLYTVHLTVDLHAREYVMIVSTGLVAGLCGPLLMWLMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNGYSVVQSFLLSPPLFSLIGGIFVCKILAVLASSGSGAPGGVFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAILLGLAGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVLSRTLRHDSIYRQHAAEH