lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MRFPPLLCPRTSPSALRSLRPLPALSSSRPLHTSLAHPNSSQSQSDLPVDGATDLSHSHFISSASPSSDFNPAQTPNAGQDIAHALKAQWEGKLSPTTSHLFKLIVPLPAPGCQPGQTPTPRPTAFLLHPSQPLSHLSRLISGSLPPPYTHSDISYLALTGSESDVDTHLRNAEKSSDNSSTNENDYAGRDEGGPFLTERKGEGGRWQEVAWSQSTDLSDFIKQSCLNEKFKIVISPERDRDGAQLKGKETELRELVLQVLIPSFASRTHYIRKRLLSLTKDLDTLNKEKRRIDYAAHKGAQRLAVMALGGGVVYWGTIIRFTFFTDAGWDMMEPVTWATGFAALLGSAAFLIYHNREVSYSSLLDLSITARQRKLYAEAGLDLEKWTEMVAEAKALRKEIERIAADYDIEWRGELEGLEKVGSREGAGGGSPRVGLPGVEIGEKKEDVRENVDAKDGSKEGERKEMEEENETKLQGEEGKVETEKIDVDKTIDEASELAEESGEQRSRTKAAQRNGEVMDSSDDDKGSKTRKGEEQESDSVTKGRAAAKKVINEK
The following text describes a protein:
Function:
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNETAWLDRVFSNTSLGHRLLDRLTLTNLRHAFYLISPYETTVESIDDVPNYNAEVSAWWLVFLTAEFFILFISGHEDRFALNDSITSICAGMLSQCFKFGGRAVAIFLYVIVWDNWRILELPWDSPWTWIFCLFFQDFMYYLGHRAVHEAGFFWGLHTIHHSSEYYNFSTALRQAAIQDAGLAIYDCIQAFFIPPSIFLVHRYFSEIFQFIMHTSLVDTMGPLGLVFNTPSHHRVHHGRNPYCIDKNYGGVFIIWDKMFNTFEAERHDDPPIYGLVTNENTFNQIYLQFHALWDILIFKGFTKDVKGEPMFPGVVNKLKATVFPPGWFPGVPVTPFFHWMSMVNPAHGVPEPEKPVLRYSPPARILVKVYVASSFLLLLAIFFHFEYDRNHLSYLDCTVKIAYFVVTMQCFGAFFDMKWYARYIEIARCCGVLIYYGVLMFDHIGAGTHRLFVISLHIMAIALWTTDVLVEKLSQCCSKNQSINPEKGDLERAPEIASISKNVQ
The following text describes a protein:
Function:
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Sequence:
MSSPSKRREMDLMKLMMSDYKVEMINDGMQEFYVEFNGPKDSPYHGGVWKIRVELPDAYPYKSPSIGFINKIYHPNVDEMSGSVCLDVINQTWSPMFDLVNVFEVFLPQLLLYPNPSDPLNGEAAALMMRDRTSYEQRVKEYCEKYAKPEDIGAAPEEKSSDEELSDDEYAASDDEEIAGKADP
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MRLRVRKASQQRSATPSARTVKTKRKHSEVEHSLSTEDAKMQKRDTGIFSTIKRFIRGNAVKVEQCTPAKRSRVDCDSDSNLITSTPTGGNLPSRANPKTRRKGPVNGDTMTGQNKPVKPNGKLEVQAETPSSPPRTTLLGTIFSPVFSFFSPANKNATAGSDSPGQAVEAEEIVKQLDMEQLEETPTSTTTDGRDLTFDPALNPRPLPHIDTTVEEGEIVTEADMPPLTAVGSNSNYPDVPPSPPAEGTYEEDWEVFDPYFFIKHVPPLTEEQLTRKPALPLKTRSTPEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQIYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCVCVQGNYIKDLNILGRDLSKTVIIDNSPQAFAYQLSNGIPIESWFVDKNDNELLKLVPFLEKLVELNEDVRPYIRERFRLHDLLPPD
The following text describes a protein:
Function:
Involved in adhesion, phagocytosis of hydrophilic particles and intracellular killing of bacteria. Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKINKKQIVFFILFSIFLNHVNGIFYLPGMIPHDFAQGEEGAIKVNKITSVHTQIPYKYYQLPGVCQPKEGIIDDTENLGEILLGDRIENSDYTFNFLTDGGKCKVINSESCSPIIKKEDLKVLEDRIQNQYRVHWLLDGLPVRQTGRLASDPGFDLGFMTLAEGQTVATAEKYLNNHLEITIFYHSNPTDNTSRIVGFEIFPTSRQYKKVENWKGDTGDDCPQYGENFEQLSVSVKEGEDQERFVLWTYEVKYTPSPVLWNKRWDIYFESNDNSVHWFSILNSLMIVFILTVMVAMIIIRTLKKDIRRYTSIDTSEDRDSQEETGWKMIHGDVFRPPSHPMLLSVCIGSGVQIFSMTLITMIFAVLGFLSPANIGGLATALIVLFVLSAMFAGYFSTRVFTIFKGRNWKKNTIYTALSMPGIIFGIFFFVNMFLRGAKSSAAVPFGTFASIIAMWFGISVPLVFLGSYFASKKPVPEDPVRTNQIPRQVPDQIWYMNPYLSILMGGILPFGAVFIELHFILTSLWDNQFYYIFGFLFIVLMILIVTSAEISIVMCYFQLCAEDHHWWWRSFLTAGSSSLYMFIYSVSFFRYLGITKFISSLLDFSYSFIMSLAFAALTGTIGFYSCYFLVRKIYSSIHIN
The following text describes a protein:
Function:
Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MTSRTNEFFGLTKNGDIDAANIPLKRISYTDPFLAEGYRIHETIVNLLVFLKKIRGAYLKDRTFSNVQRLSKPLMECSLEELSKLELDEVQRDEIEHEVSSAISSCIHQIAKLQEIVKEQQSQIPKKSGWLQGLRDPSKLSKKETLVAHHSSVLWYLQSELSDVSSVLYHLQDLRLKRGQEKRNIASDFLTKNPTDENSAVEIPESELQTFFTQQQLQELEQENDVLLQEFEHTMERLRDTGKSLADITRLQSEISAQLSIQSSAAEKLYDDALNVMDSLSGGNQQLIKAKSRSSRTARLLFCIFTVMGLLLLSLDRIV
The following text describes a protein:
Function:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MATDAQVHGEDGAMPADNTALLAGASYDKLVTPNSGDTPVSASHRAGNDQNEQETSADQGEGYDDLMHGINSFWAIVFPVCVTMIIASLVVVNYRSSSIEASMSTYLVYGDSGADTSSSSSSGGSGIGESLVNALVIIGAIAVLTFGMALLYKYNCMKFLSGYIMFASTAILSFVGGQLVDEIVNDQFGWAVDWPSFLFVMINFGFVGVISIFYQKGTPKFVQNGYLVMVSVILAWEFSMWPEWTTITFCVMFACYDLCAVLTPCGPLKYLIGLIQEKQAPLPGLLYEADVRDGVSHDHHRQQQQQQRQQQEQRRPKNTPTDEVTAAQRQSSSATSQSSSNSNHNASVTNSTHALPPQAPVAEPVPMTQPSTDRTESSPIPLMSSGRPRNVAESNFTTYECETMEALVSLLSVFYETFSPEDTWKAPQVAEKFFPTQDRLWLLIFHKYYVCSCSMDMPCPVQARRDRRQRQQEEEDEDDKTIKLGLGDFIFYSVLVGRAAIKDFSTFAVTFVCIVMGLGGTLFLLAVLHKALPALPISIFLATIFYFLTEYIFIDFCSFMMTFPAAV
The following text describes a protein:
Function:
Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and class II flagellar biogenesis.
Sequence:
MRVLLIEDDSATAQTIELMLKSEGFNVYTTDLGEEGVDLGKIYDYDLILLDLNLPDMSGIDVLRTLRVAKINTPIMILSGSSEIDTKVKTFAGGADDYMTKPFHKDEMIARIHAVVRRSKGHAQSVIKTGDIVVNLDAKTVEVNGNRVHLTGKEYQMLELLSLRKGTTLTKEMFLNHLYGGMDEPELKIIDVFICKLRKKLAASAHGKHHIETVWGRGYVLRDPNEQVNAA
The following text describes a protein:
Function:
Involved in vacuolar protein sorting.
Miscellaneous:
MISCELLANEOUS: Present with 112 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRMIQRERKREKEEGQLKERTVVNMADPDDNEAEATGLQQYSGETTRDDNEESMNDSFTLTSRNRGRSNTISSIVSGYEIMKEHMDKEKFMYLILASLLLYMGFVAAFAPRTSLSRDFRRFHSSRLTNAEVYRIYLNSLQQENRAKEHVYKYAGYMSNGASDSSTFKYTLDEFLDMGYKPKVEKYYPWIGEPVDTNVAPLENGKVVYEASMIEDRVKGDPASHARKRQKGFHQYSKNGSVTARYVFCNYGSISDYKLLLKKNIDIEDKIHIVRSGKILPGLKVKNAELYGASSVIIYTDPFDDGKVTEENGFLHYPYGPARNPSYIRRDSVNYFSDTPGDPTTPGYPSKDSDTEHMSPVGRVPRIPSVPMSARDVQPILERLNGRGFQIGPGSNIKDFGSFTGPSSSIDKVHLHNELTYNIKEMSSVEVSIPGIFTEGEIIIGAHRDSLASSSAGDANSGSAILLEIARGMSKLLKHGWKPLRPIKLISWDGERSGLLGSTDYAEAHAAILRRRALVYLNLDNAISGTNFHCKANPLLQDVIYEAAKLTEFNGHEDWSLFDHWKYTSNATISLLDGLSSYTSFQYHLGVPAAHFQFNANDTSGAVYHSNSVFDSPTWLEKFTNSDYKLHNTMAMFVGLTTLMLSENELARFNTHVYLKKIYNWYIAWHSNLSSAFPQDDEVNSLAKRVLDLLKVATQEDSIQFDQQNGILYKECREALPVWAFYKKIKSYIKLQRSNSKSKQIDQLFITHRGLKDREWMKYSLLAPSKFEGSVGEVLPGLHEGLADIDRNEVIQWLTILLSQFSNVRYLLQ
The following text describes a protein:
Function:
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
Subcellular Localization:
Nucleus.
Sequence:
MPRRKQQAPKRAAGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHALSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEISRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVKLHLSKTHSKSPEHHSQFVTDVDEE
The following text describes a protein:
Function:
Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MPVDSMFGTTINVLAKAVDLRARNHTMISANLANAETPNYTPKALSFEKELGAALKGNKTGSPATTHPRHIPLKGQAASVQSVEGTVIETPAPTPGRDNNGVELEAEMSRMAENQIMYNASIQILTKKFEGMKYAIKGQ
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
MEEAGRAVAAAAQECCPAGRVLLLAGGGANGGDALVAARHLFALGRDVAVLALPAKHPLTRSNRRRLARIGVEVAPLTPASLRRELKTAALVVDGLLGTGFTPPLRAPLAELVAQVNASGVPTLAIDLPTGLDALTSEVSGDPLRAAWTVTLSGLKPALLFGPAAYLAGEVTLADLRSPPDWALEEALASRPTDAEIAALLPVRHADAHKGTAGRVWVVGGHPGTVGAAALAGVAALRAGSGLVTIHSATDVPLVMPELMMRCHADLSAALMEMPEEQRPDALCVGMGLGPDAASIARQLLGWRLPTVLDADALQPELAGAGHDACIWTPHPGEAARLLGTSTPDIARDPIAAARALQEKFGGVVVVKGGPSVIAHTGGVWVSRGGHPGMASAGMGDTLSGLLASLLGQGLSAPDAALAGVTLHARAGELAGAKHGYGLTATDVSAELGRAWLGLVGG
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MNLLQVVRDHWVHVLVPMGFVFGYYLDRKNDEKLTAFRNKSLLYKRELKPNEEVTWK
The following text describes a protein:
Function:
Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAAAVGRDALPEHWSYGVCRDGRVFFIDDLTRSTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFSEEGASYFIDHNQQTTSFRHPVTGQVSPENIEFILQEEQNSPMSNQQINQRPSSMVSESSTAVTMSAVDTKPGSKVMKAGNKVHSFGKREQAIRRNPNVPVIVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREESVLGSIPLPSYVISPVGPEDRINRKFSFKAVHTGMRAYIYNKNSVIGSQAEHSGMRTYYFSADTQEDMNSWIRAMNQAALMQTRSSLRRETEKADQRAVPQVNHVDACKVCVKAEATDTKESYQKSAEMLGYDKREEIRREKEEEERYIHRKEALETKKGKAKHALTEADSLFPDLTNAPRSQVAQSLPIEKNGTLPSSLSMSAGLAEQNGTSSYKRGFVPRTNPDKQIQRKSNMAQVEHWVKVQKGDTKSLASDLTLTRQGPNPPFSENYHTLPKNTRQPSGSSPPPLSRNLPSDYKYAQDRVSHLKMSQEERKANKDGTVWQLYEWQQRQQFKHGSPTAPLYVGSSDFIDRGKSKSSLDVPRSISVPPSPSDIPPPGPPKSFLPRRPHTPAERLTVKPSDERQTVDSPFAGSPRKIRSNALKSSTHIDRRSMPSMGYMTHTVSAPSLHGKSADDTYIQLKKDLEYLDLKVSGRDTLKERSTKPVKVAESDIDVKLSVFCEQDRILQDLEDKIRALKENKDQLESVLEVLHRQMEQYKDQPQHAEKISYQQRLLQEDLIHIRAEISKVSTEMENAWKEYLKLENDVSQLKKALQEQMNSSLVSQEKTQIQKDLWRIEDVTAGLSANKANYKTIVDSIKNPERKTVPSFSQSTVPSLPASLTTVESKPSVPQSPPSSLVKPSLEVRLYPQPYFQSRTQQQVPQLKKIEPPLQSPVRLTPKVEDEAPPRPPLPQLYSPEDQPPAVPPLPREATVIRHTSVRGLKRQSDERKRDRELGQYVNGDYRVELRSYVSEPELAMIGGDLSQPSSGFITVDSGYQTLPTRGLSGSTSRLHQSSTISSYATLRRDRSKERPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERQSVSSRSFIRPISADIGSWKREQEFDLQLLERAIRGEEKDENEWLKVQPVAVAVTETDLEPQDYDLDISRELSKPEKVAIPERYVELEPEEPLSTEELAARQRKAEKIKNILTKSSMHNLQPTIAQDKHNSVDLDSQLQEQERIITISYALASEASQRSKEVAAQQLTYPPKAPSPSVPQPPHSPLSNGFHYTFV
The following text describes a protein:
Function:
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
Subcellular Localization:
Cytoplasm.
Domain:
2 residues (Tyr-62 and Arg-65) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
Sequence:
MNVADLLASSRHCVVFTGAGISAESGVPTFRGPGGLWERYKPEELATPEAFARDPALVWRWYKWRQEVIYNARPSPGHYAIAELEAMGVVRGVITQNVDGLHQRAGSRLVVELHGSIWRARCVKCGSVYILDKPVEEVPPLCRKCGGLLRPDVVWFGEPLPQEAWRAAVELASVSDVLLVVGTSGVVYPAAYIPRIAKEAGARVVEINVEPSAITPIADVFIQGRAGEVLPRLVEEVKRRLRTRQALTP
The following text describes a protein:
Function:
Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MDVQDFLNCNKLKISKEKISNLNKSKIGILITNLGSPEKLTYWSLYKYLSEFLTDPRVVKLNRFLWLPILYTFVLPFRSGKVLSKYKSIWIKDGSPLCVNTHNQCLALKKILNEKYNNKVVISYGMRYGERSIKKGLEYLQKENINKLLVLPLYPQSAECTVSSTLDCIGKNLKNWSNVPELRFISGYCLKDIFINTMKENIENYWELYGKSKKLIISYHSLPIRNVIQGDLYPFFCIESTKKLVKSLNLNKDDYILVFQSKIKGQQWVKPCIEDTIIRLAKQGYKQIDIVSPSFSSDCLETLEEIKIHYQQLFRKYSNGNLRYINCLNDTTIGIKLIMNLIEQNIIGWV
The following text describes a protein:
Function:
May be a cell surface adhesion protein that is required for normal cell expansion.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MANVISISHFTLLALPYLLLLLSSTAAAINVTAVLSSFPNLSSFSNLLVSSGIAAELSGRNSLTLLAVPNSQFSSASLDLTRRLPPSALADLLRFHVLLQFLSDSDLRRIPPSGSAVTTLYEASGRTFFGSGSVNVTRDPASGSVTIGSPATKNVTVLKLLETKPPNITVLTVDSLIVPTGIDITASETLTPPPTSTSLSPPPAGINLTQILINGHNFNVALSLLVASGVITEFENDERGAGITVFVPTDSAFSDLPSNVNLQSLPAEQKAFVLKFHVLHSYYTLGSLESITNPVQPTLATEEMGAGSYTLNISRVNGSIVTINSGVVLAVVTQTAFDQNPVSVFGVSKVLLPKELFPKSGQPVATAPPQEISLSPESSSEQPSRLVSPPREIVSSGAVKRPLGFLVLWCWCIAFCYVLV
The following text describes a protein:
Function:
Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation.
Miscellaneous:
MISCELLANEOUS: Present with 8100 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTDITPVQNDVDVNGNNVNDDVSSNLKRPIDQGDPSNGLAEEENPANNQLHLKKARLDGDALTSSPAGLAENGIEGATLAANGENGYNATGSGAEDEQQGLKKEEGGQGTKQEDLDENSKQELPMEVPKEPAPAPPPEPDMNNLPQNPIPKHQQKHALLAIKAVKRLKDARPFLQPVDPVKLDIPFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMARNIQASFEKHMLNMPAKDAPPVIAKGRRSSAQEDAPIVIRRAQTHNGRPKRTIHPPKSKDIYPYESKKPKSKRLQQAMKFCQSVLKELMAKKHASYNYPFLEPVDPVSMNLPTYFDYVKEPMDLGTIAKKLNDWQYQTMEDFERDVRLVFKNCYTFNPDGTIVNMMGHRLEEVFNSKWADRPNLDDYDSDEDSRTQGDYDDYESEYSESDIDETIITNPAIQYLEEQLARMKVELQQLKKQELEKIRKERRLARGSKKRGKRSKGRSGSKNASSKGRRDKKNKLKTVVTYDMKRIITERINDLPTSKLERAIDIIKKSMPNISEDDEVELDLDTLDNHTILTLYNTFFRQYESSSGASNGLDGTSGVTRDASSLSPTSAGSRKRRSKALSQEEQSRQIEKIKNKLAILDSASPLSQNGSPGQIQSAAHNGFSSSSDDDVSSESEEE
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSSQLNDPTPIPAQSSLSFTQGFLLGQLSVVLLIAAFIKFFIFGEAPPPPSRGLSHRSATHRRSNSIFSSAQHDGSTRTLREKPSNSNVLRPVPSSATNTRSILRKTYYTAIPTNPSSKHGRHRIHHSSHQPESLDWFNVLIAQTIAQYRQTAYLLKDSPTSSILNSLTAALNNPEKKPSFIDKITVTDISLGEEFPIFSNCRIIAVDDPNSDGGRLQALMDVDLSDDNLSIAVETQLLLNYPKPCSAILPVALSISVVRFSGTLCISLVPASTPPLDTPSHSPSPPTAQTTTAGRSKREDQTSGSHSHAGGSSKEPSGENPPKTSPKSNVAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVHAWFEERVVEPRVQVVGLPDLWPRMGRTGVRTGDDSETGSNVPRSSTAADASGSARHEDSSREPEVLRFGSLLGTRPPFDLASRTSSFNVETGDLRSRSMTREESNGNLSDQFHMPGSLPGSGVATT
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAASLDPQIDVPLEVEGCLIMKVEKEPEWAVEPSLEASEGSESETFRRCFRQFCYEDVAGPHEAFSKLWELCCRWLKPEVRSKEQILELLVIEQFLTILPKKIQAWAQKQCPESGEEAVALVIHLEKEAGRLRQQVNSPVHSEKQAPLGAAWEVTDFQPEQVETTGVVSLEEAGSLHSGHKEQLNRKREHRPLPKNAQPSPWVPAPAHEWNSMDQEVTTTRQPVVSQGPVKDVHMARGFSYKKSVHQIPAHRDLYRDIRKESVGNMVSLGSTASASSKIARLEQRKEPWTLGLHSSNKRNIILRSNHIKEKPVHATQIPARSAGRVWGEQQHWGLEDEKIAGVHWSYEETKTFLAILKESRFYETLQACPRNSQVYGAVAEWLRECGFLRTPEQCRTKFKSLQKSYRKVRNGHVLEPCAFFEDMDALLNPAAHASSADKPKEILSLPRLKRVDISAKEQINLVEEEDAAEESDGDEIGIEFIRKSEIRGAPVLFQNLSGVHWGYEETKTFLDILRETRFYEALQACHRKSKLYGAVAEQLRECGFLRTPEQCRTKFKSLQKSYRKVKNGHVLESCAFYKEMDALINSRASAPSTNTPEEVPSPSGQEGEDIEIEPQEPIGWEPEEASQEAMAEDSGSERMSEEEIVQESAFQGPPGLLPSPSDFEIGGSFKEDTTQVIYKDMEQHRALIEKSKRVISQNADPGKYCKREYISGRQWENLQGIRQGKLMSQPRDLGKAVVHTRPFMGKRPYRLLKYGESFGRNARLMCRMTHQKENPYKCSVCGKCFGRSRSLIRHQRIHTGEKPFKCLDCGKSFNDSSNFGAHQRIHTGEKPYRCGECGKCFSQSSSLIIHQRTHTGEKPYQCGECGKSFTNSSHFSAHRRVHTGENPYKCVDCEKSFNNCTRFREHRRIHTGEKPYGCAQCGKRFSKSSVLTKHREVHSREKLLPHPPSSCSPENPPKGKTDEFRKTF
The following text describes a protein:
Function:
May be involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery.
Subcellular Localization:
Early endosome.
Sequence:
MVVPRGQEHRAPQEVETREDEEQNIKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCNFDIDIDLLFQENSTIGQKIALTEKIVSVLPKMKCPHRLEPHQIQGLDFIHIFPVVQWLVKRAIETREEMGDYIRSYSISQFQKTHRLPEDDEFMQRKEKAIKTVTDIFEVYKPQRKYKRQKGAEEILDEESKVHATLLEYGRRYGFSRQAGKTEQTEDKKIVLPSGLAAAGKAEPCDEDDLRAAEELRIKTLMTGMAAMATEEGKLTASTVGQIVGLQSDEIKQIVSEYAEKQSELSAEERPERLGAAQQHRRKVASLNKQILQKTKLLEELQAKFVDLQAKCTEAKKTLTEVESYSEKLDKELAALETIESQADSSVLQNLRMLVAINENLKSQEQEFKAHCREEMERLQQDIENLKAEAAENGEEEEPNKLIDQQYQTEKEKLQKIRLLLARRNREIAILQRKIDEVPSRAELTQYQKRFIELYSQVSATHKETKQFFTLYNTLDDKKVYLEKEVNLLNSIHDNFHQAMASSGSREQFLRQMEQIVEGIKQNRMKMEKKKQENKMRRDQLNDEYLELLEKQRLYFKTVKEFKEECRKNEMLLSKLKASSS
The following text describes a protein:
Function:
Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.
Miscellaneous:
MISCELLANEOUS: Present with 688 molecules/cell in log phase SD medium.
Sequence:
MISPSKKRTILSSKNINQKPRAVVKGNELRSPSKRRSQIDTDYALRRSPIKTIQISKAAQFMLYEETAEERNIAVHRHNEIYNNNNSVSNENNPSQVKENLSPAKICPYERAFLREGGRIALKDLSVDEFKGYIQDPLTDETIPLTLPLGDKKISLPSFITPPRNSKISIFFTSKHQGQNPETKISRSTDDVSEKKVVRKLSFHVYEDE
The following text describes a protein:
Function:
Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAREAFVRIVPMDNSAVAAVFEELAELLEFRGENPFRIRAYQNGARAIRDLDEPIANLASDPERDLSKLPGIGKTIAEKTKVLLETGSLPQLEELREAVPEVVIQMSRIPGLGAKKASKLREELGIESLEDLAAACREGRVASLKGFAKKTEAAILDGMAIAKAASERIYWSKADDLTREIGKHMQVCDAIEQMEWAGSYRRGRDTVGDLDLLAVASDREAAMDHLANFPGLVSVIGSGDTKMSIRVGKAFQVDMRLVDAEEFGAALQYFTGSQAHNIHVRRIAKDHGLKINEYGVFKLDDESRVAGATEEDVYQSIGLPWIAPELREDRNEFDWAKSDSLPNLIDTDDVLGDLHMHTSATDGQNTIAEMADAAIERGLKYIAITDHSKRVTMAGGLDAERLLKQWEIIDEIRPKYEGRLVILKGIECDILEAGGMDLPDEVLEQGDWILGSVHYGQKQPRDQITDRILGAIENPHVDCIAHPTGRILNRREAYDVDMDAVMQAAKENNKFLELNANPARLDLNDVHLSAAKKRGIPIVINTDAHVTDGLWVMRYGIRQARRGGLTAADVANTLPYEAFAKRLAEVGG
The following text describes a protein:
Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell growth and differentiation. May contribute to cancer.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.
Sequence:
MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTPLRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSAFGFPGGGAPTPPQGSFWDMTPEQQGMYSANLIMGTMQSCPGKSVMAGVTGFGLGGVFGLFMASMAYDAPVGMGVQTMSDLPFKQQMKIQFTDMGKRAWSSAKNFGFIGGVFSGTECCIESLRAKNDIWNGVAAGCLTGGGLAVKAGPQAALVGCAGFAAFSAAIDVYMRSDNKAPPSTDEDL