lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3 (By similarity). Plays a role as a coactivator in nuclear receptor-mediated transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSKSRAEAAAGAPGIVLRYLQEQNRPYSAQDVFGNLQKEHGLGKAAVVKALDQLAQQGKIKEKTYGKQKIYFADQDQFDTVSDADLHSLDASIMALTAKVQGLQQSCRHMEAELKELTSALTTPEMQTEIQELKKECARYTERLKNIKAATNHVTPEEKEKVYRERQKYCKEWRKRKRMTTELCDAILEGYPKSKKQFFEEVGIETDEDHNVTLPNP
The following text describes a protein:
Function:
Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAGCSEAPRPAAASDGSLVGQAGVLPCLELPTYAAACALVNSRYSCLVAGPHQRHIALSPRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGELGDIYDDQGHIHLNIEADFVIFCPEPGQKLMGIVNKVSSSHIGCLVHGCFNASIPKPEQLSAEQWQTMEINMGDELEFEVFRLDSDAAGVFCIRGKLNITSLQFKRSEVSEEVTENGTEEAAKKPKKKKKKKDPETYEVDSGTTKLADDADDTPMEESALQNTNNANGIWEEEPKKKKKKKKHQEVQDQDPVFQGSDSSGYQSDHKKKKKKRKHSEEAEFTPPLKCSPKRKGKSNFL
The following text describes a protein:
Function:
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
EFSEPSFITESYQTLHPISSEELLSLKYESDYPLGLLRDPLQPESLQGDYFTIKQEVVSPDNMCLGRISRGKLGGQESFESIESHDSCDRLTQSWSSQSSYNSLQRVPSYDSFDSEDYPPALPSHKSKGTFKDYVRDRAELNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYVPEELHAMLDVKPDTDE
The following text describes a protein:
Function:
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Miscellaneous:
MISCELLANEOUS: Most adhesion GPCRs proteins undergo autoproteolysis at the GPS region of the GAIN-B domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS region.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWGFWLLLFWGFSGMYRWGMTTLPTLGQTLGGVNECQDTTTCPAYATCTDTTDSYYCTCKRGFLSSNGQTNFQGPGVECQDVNECLQSDSPCGPNSVCTNILGRAKCSCLRGFSSSTGKDWILGSLDNFLCADVDECLTIGICPKYSNCSNSVGSYSCTCQPGFVLNGSICEDEDECVTRDVCPEHATCHNTLGSYYCTCNSGLESSGGGPMFQGLDESCEDVDECSRNSTLCGPTFICINTLGSYSCSCPAGFSLPTFQILGHPADGNCTDIDECDDTCPLNSSCTNTIGSYFCTCHPGFASSNGQLNFKDLEVTCEDIDECTQDPLQCGLNSVCTNVPGSYICGCLPDFQMDPEGSQGYGNFNCKRILFKCKEDLILQSEQIQQCQAVQGRDLGYASFCTLVNATFTILDNTCENKSAPVSLQSAATSVSLVLEQATTWFELSKEETSTLGTILLETVESTMLAALLIPSGNASQMIQTEYLDIESKVINEECKENESINLAARGDKMNVGCFIIKESVSTGAPGVAFVSFAHMESVLNERFFEDGQSFRKLRMNSRVVGGTVTGEKKEDFSKPIIYTLQHIQPKQKSERPICVSWNTDVEDGRWTPSGCEIVEASETHTVCSCNRMANLAIIMASGELTMEFSLYIISHVGTVISLVCLALAIATFLLCRAVQNHNTYMHLHLCVCLFLAKILFLTGIDKTDNQTACAIIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLHLCAFGYGLPVLVVIISASVQPRGYGMHNRCWLNTETGFIWSFLGPVCMIITINSVLLAWTLWVLRQKLCSVSSEVSKLKDTRLLTFKAIAQIFILGCSWVLGIFQIGPLASIMAYLFTIINSLQGAFIFLIHCLLNRQVRDEYKKLLTRKTDLSSHSQTSGILLSSMPSTSKMG
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MAKMIMLYGFASLASPKAVKEFLEEHTGEGTVSGVEVGQNKGSRAHAIVEFTTVEAADFIKCLARERLSYGNSFLKASSAKRRTPHFAKRTPHYKLGGDLKLNFGCQISKDKFSVFWSQENVSVKLCSDLRKFGFFLSYESVDYKLELSNESIWQIELHRPSGHSVSIGQSSAICLELPSRALIPKALKDFFHYKESLVQFTLLPGFVFSCNSDLNQDGKHALEMLFHLRECCYDPVSWLREQYRKHVSSGQFPTSPAVALDGGLIYVNKILVTPSKVYFCGPEISLSNRVVRSYPDEIDNFLRLSFVDEDLGKLYSTVLSPQISSTNGERRTRIYERVLSTLRNGIVIGDKKFETLAFSNSQERENTLWMFASRPELTAADIRERMGDFREIKNVTKYAARLGQSFASSREALHVDSNIGKISAELAETVAKKCGYAIYTPSAFQIRYGGYKVTLRNNMFKYKSESTSLDILANSKYQREGVARLRLDNVFERKQREVVARLDAILTDSSKVQEALELMSSAENTNVLKELLNCGYKPDAEPFLSMMPQTFHASNLLELRTRARIFIQNGQAMMGCLDEKGTLEYGQGLMVVAKKPCLHPGDMRVLRAVDVPALHHMVDCVLFPAKGERPHTNECSGSDQDGEIYFVCWDHDRIPPLQFQPTAYTPAPEKILARDVTIEDVEEYFADYIVNDSLGIICNAHVVYAYSEPDKAMSNRCPDLVKLSSIVGDFSKTGVAATIPSRLRVKIYPDFMEKQDKTWYESQHIVGNLYREVNGIAPSTTTIKSFAKEGAMQFYDTDMEVNGFKEVAMQFDGFKYRTEYDNKLGNLMDYYGIKTEAEMLSRCIMEMAKSFDKKRDLEAISFSVRSLRKEARAWFNKKKNDSDSSHKDV
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MATEKSQDFNITSVGYYKRDNETNVTVDVQPKFANSNYDRLMEFQEPGDYIQEIDMNLGSPEVPHDGKLRIFLNLYSIIFRSKARFVNPTVYIVSHMGMIFMSYKKLEKADPEIDEEDQKKKDIARKKAMEYTAGANFAHYWTKKSENEEIPEDYATSNCKAVMKCDVEVGGKKELVVYSAHIDALEKESGKHVSTRTTRRTNFWTYLHWKMFFGNDSTMVLGAGSVSLELSNWALRSIEALKFEDVFAKMEKIRREKNEERAQCEEFKKAPFQKWTMDQGKERFRQFLSQVKNACTHSDGCFLATEANKMWHFEKVDEEHDEIREFASLVKTKMAVWKINFPNECS
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLTRYQIRDEYSLADPELYGAADRDDPEALLEGVAMAGLVGVLRQLGDLAEFAAEIFHDLHEEVMATAARGHGLMVRVQQLEAEVPSIEKAFLSQTSHSLFFSNAGVDWHPNLHAEQNLVTRGDLPRFVMDSYEECRGPPRLFLLDKFDVAGAGACLKRYTDPSFFKVEPASFGAAKTEGQREKRIRKVKKKGSRWRNGETPEVQPPSHAKLQQLFLEERVENGYGNPSCLVKLKRRHLNGSPFDSKTGKSYMEKFLEPSTPKQKVLHEISVPSPLKLTLDNSSEPGLEILEISMVSPAKKSSQGEGSACSSPNEKEVVSIPYREKFNGDVIDGKIMKVPEPADLDTNDISSSTLHKVAFVEELAVDGELKTEGSADGYHSEDLTSEIDNYMDALTTMDSEMETENEYRTKNNGLLIAKNRGRNSDGDEENLEFQAHSSDSQSFGNSPASDYGNGSIKCNRSSFSDSDTLSSSAENATSGGDGAAKVFLSSEPGAAKGVDRPSSRLTDESQGTRSHELVVPYDSGIEEDKTPDLGEASCSSCLTDSSPALLPSDHGVHSPPDVLVGPEVEEATSDSIEVGSRLSYTDENGANRADGKAFGSDGPSKTLNDIRFVGSAENHLDGEDPNAVSNVLLHLSDVLGITPENKGTDHFPNDVLQTESADEDYSENLVDGKIVATHLSVLPNLSVLPTEKQQLCSFLPEVEVHSDVIPTICSSDGIEPYKLISKADNARTENGINLENSTPLVETQKSNNLEQQKLSDLTNIVPELELASVELDDPYTDEQSDFDKIPRAAEGEEIMGTSTCCVDAVGGDAVPLKLPYTFPNYTCHEDHINLDSVETEQVIADVSLSTAAITGADNDSDDCIHPCPDLASRNHIKLQEPLSEFPHPHPKGTDCKEVDSPENLTETEAQDKVNLLEVSPADTPCKLVSSDHCNLKTVAGDDESSLAEETQYTSCGKGATPAPTYSAPGNQHLESNSPHQSHLLENSEAELCLPIGGLPGPGDPKANSLQFESDEVSLQEYEATCNSSRLQSGQIQSQNHTDHERCEQLQSLNHLEKCVDPPPPESHSEYLPCQPSESEFLLRSSGLELGVSKLAMDPLESALPSFGLLPQAAHVNLEEVPPLPPLPPMQWRMGKTQIASLASPRYSIEASQHSFPPLQPFADEKAQFGFPASQTRILQHQNPYFPITTVEDEKSQQVSEQSMDNLAQLIPFSLQLQTIASDADSQSNYLSLGGTQTPFLTSPSMPNERPEYGVLALDGEKAHLNSIPFTPMPTIEYTTCRHDPESSLEKPIEPSQQLGPETGSVDKELQPTLHYYSEEELQNPFDMSMPPPTVEAEQCQRALLTSDGETPQVEGVEVGKPNGNLATKLPRPPKPLIDAVAAHDKSKLRKVAERVRPRVERKIDERDSLLEQIRTKSFNLKPAVVTRPSMHGPQTNLKVAAILEKAKTIRQAFAGSDEDDDSDNWSDA
The following text describes a protein:
Function:
Binds to 23S rRNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MGSRLGRRVIHFANLPLKVMLPPAPLSSVQEFAVRTVPSASKVDIRRCLESMYGFSVAEVRTLNMEGKKLRRGPFLSAKPDYKKAYVTLRAPLAVSRDLFPIGAILAERERKASAAAARRKAVEGAEVEGESKGKHWMEDEREGFSRAGCGKVVYGNPGRLGRKRRGGDKVKEQAGDEAAKFPWSGMRLATEKPRRVRRSPSKKGIVLKQKSRKEHQEQRKRMRSRCSMSADTFYHEITKEYKPPTFARTARSMSSTVTLSFHPPASFKADI
The following text describes a protein:
Function:
Target of p53/TP53 with pro-apoptotic function.
Miscellaneous:
MISCELLANEOUS: Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization.
Sequence:
MSEVKSRKKSGPKGAPAAEPGKRSEGGKTPVARSSGGGGWADPRTCLSLLSLGTCLGLAWFVFQQSEKFAKVENQYQLLKLETNEFQQLQSKISLISEKWQKSEAIMEQLKSFQIIAHLKRLQEEINEVKTWSNRITEKQDILNNSLTTLSQDITKVDQSTTSMAKDVGLKITSVKTDIRRISGLVTDVISLTDSVQELENKIEKVEKNTVKNIGDLLSSSIDRTATLRKTASENSQRINSVKKTLTELKSDFDKHTDRFLSLEGDRAKVLKTVTFANDLKPKVYNLKKDFSRLEPLVNDLTLRIGRLVTDLLQREKEIAFLSEKISNLTIVQAEIKDIKDEIAHISDMN
The following text describes a protein:
Function:
Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of iswi/snf2h and acf1 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSESQDLPGAIVNRIIKASLPEGVLCAKESRLAIAKAAKVWIHYLTAASIDFSSHSGRSTISPKDVFQAIEEIDFENFKPQLEEYLAALKSEKEKEKEKEKEKEKEKEKEKDSNKDDTKSKDENKSSKKSSSSSKDEK
The following text describes a protein:
Function:
Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
Sequence:
MNASTEPVILKLGGSAITDKGAYEGVVKEAALLRIAREVSGFRGKMIIVHGAGSFGHTYAKKYGLDRNFDPEGSIVTHESVKKLASRVVEALNGFGVRAIAVHPMGCTVCRNGRIESMYLESIKLMLEKGFVPVLHGDVVMDLELGTCILSGDQIVPYLAKELGITRLGLGSAEDGVLDMDGKPVPEITPENFEEFRQCIGGSGSTDVTGGMLGKVLELLELSKNSSITSYIFNAGKADNIYRFLNGESIGTRISPDKRV
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Miscellaneous:
MISCELLANEOUS: Present with 1200 molecules/cell in log phase SD medium; MISCELLANEOUS: There are 2 genes for uS17 in yeast.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTELTVQSERAFQKQPHIFNNPKVKTSKRTKRWYKNAGLGFKTPKTAIEGSYIDKKCPFTGLVSIRGKILTGTVVSTKMHRTIVIRRAYLHYIPKYNRYEKRHKNVPVHVSPAFRVQVGDIVTVGQCRPISKTVRFNVVKVSAAAGKANKQFAKF
The following text describes a protein:
Function:
Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to centriole distal ends and to centriolar satellites. Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP.
Sequence:
MMAQSNMFTVADVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW
The following text describes a protein:
Function:
Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size.
Sequence:
MTETESQKQIKLEICIDNLESAENAVAGGADRLEVCSALQLGGLTPSVGFVSILSYKYPDIPLYCMIRQRAGDFVYNEDEMAANMEDVEWLKKAGATGFVFGALTSAGSLDRTSCQSIIETARPHPVTFHRAIDVAYDWKTCLEDAIDVGFKAVLTSGQEPSALDGVYIIREMQELHKGKIDVLAGCGVNSSNVANLVEWTKCHWYHASASVAKKNAPLNKVSMGKQDNQPSRVTSLEEVRMLKATLAPV
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Sequence:
MTFPILILAAPTGAGKTSLITELDPTRFEILSFDSRQIYREMPIGTAAPTKEQQSKIRHHLVEVLSPKESIDAGLYNRMAEEALQKVLNTDKIPVFTAGTGFYLKAFLFGMFPVPEISVSVRERVLSMSIEEKKVLLNDLDPEALDKIFSGDDYRLGRALEVNLMGEKWSRLKIDPNTSAIYKYNLEIRLGIFLDLDRKELYERINLRAKRMIDLGMADEAWEIRERYGESCPGLKSLGYNFALENKKGNSNVETFLVDLSQSHRNYAKRQITWFRKENYIQAMDRSEALERIKHIK
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MVDSEMDQIEDDRLMGGERKKSRGESRYRSDSKEQRHRSKSRERSRKDRSSRSDRDRRRDRDDRRSRSPGREDGRRSSSREYRTSRRNSFSPPPETVPLHLRLRKIENWDVPPVGFEEFTAMQAKASGQFQLPSHMLKTTTGGLHERGGYQASTHAINATNFDAAAETFLSNIGLNSGSGEVGSHTNGRGFGSTSLSSGVNVGMAGAGFGINRGLSMGMGMNGRNQQPIARQFKRLYFGNIPVDCIEERILSFASSSYEKLGLPKDPGNAAVNAYINRERNYAFVEFRSPEEATRAMALDGSLFDGNILKVRRPKDYNPEAAPDGATQPSIAPATSAQESLDKIFVGAIPTYLSDDQVQELLKTFGELKTFSLIRDSATGLSKGFAFCEYVDGQITDAACQGLNGMELGEKKLIVQRASVGSNKNTISAVGQSQLLPMEILATIAKDPCKVTRVLLLLNMVVSEDLVSDEDYQDILLDIQEECEKFGTILDIAIPRPVSGQSNAGVGKIFVKFDNVKQSASAQHALAGRKFADRVVIASFFDEDKFDQQDF
The following text describes a protein:
Function:
Negatively regulates long-term potentiation and modulates adult synaptic plasticity.
Subcellular Localization:
Synapse. Synaptic cleft. Note=Detected in both the presynaptic and postsynaptic regions of the synapse and is secreted from neurons into the synaptic cleft. May be released by neuronal dense core vesicles which mediate the release of cleaved neuropeptides.
Sequence:
MAGSQAQWRPPRSCDIYCSELKHCKSLRNRFHEYYTYGRAPDCQQWKQDYQNCKDWEKNHSTQAKDSLQESERKRLADQRKFTPVWELRQKPPSDWHLPLNQGEPQDP
The following text describes a protein:
Function:
Together with TRK1, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQLSGFSTNGSGSLNTIVCEKLLFKPNFVQDSFIIGMTILCSVILYGSGNLRYIDALLLASGSCTQTGLQPVDLTQISIYQQLTILLFGVLSTPITVNLGLTLFKLYFYNKRYDMVITNNKLRMTYTYHTVRRRDTPEPSKVGNRKIRVLLDQGNQMHRPVAPETKAEEAEHQENEKHHRHHFRLRKFANAIDRPSFFRGNTMPALPSYAGVRNSQENEDRTEALSPALGKRRMASIDNGSLSVVQNNARNNPVDFYIPSSFEESSFQTIPEDFEPQVHDHENQTQLNHHLDNNSSISSHNPSLETANDGNQETVSSSNSNYSTTRVDNDPHVASYSPQNSNFDHQAAATTNDAHQNVVRGSAITIAPTPVPRHNRRPIYFADDTNGAEQEKGAHRLDGRGRKRGKSFAVTPTLHRNERSMSVLPFQLAKSFTSALPRRLTFNRTHTKASTMSLPYLSYNATVGRNSAFYALTPVEREELAGIEYESLRILTVILVVYFLFWHILGLVAFLIFIYTAKTSGRVVTDGGINRGWWAAFTSSSLFDNLGYSLNSDSLNSFQKAIFPQVLGTILIFLGNTFFPIMLRFIIWIMIRTTRFSPNFQQALYFLFEHPRRSFTLLFPSKTTWVLFLNLTLLNFASFFFFMVLDLGNSYVDKIPVGYRIMNAIFQNAATRSAGFTVVDLSQIAPAVMVTYMFMMYISAYPIAMSIRQTNVYEERSLGIYAADTENDDDNNINNNNNDNNTPKRKNFLMDHIQRQLSHDLWYLFLGYFIITIVEGRRLESEAEPQFTLFAILFEVISGYGTVGLSLGYKNDPSLTAQFRKISKLVMVALQIRGRHRGLPSALDRAVLMPSDKNFDREEEDYMRRHGKKNTNRADPVPSS
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Endosome. Membrane, caveola; Peripheral membrane protein. Melanosome. Membrane raft. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Membrane-associated protein of caveola.
Sequence:
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAESVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
The following text describes a protein:
Function:
Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme.
Sequence:
MRFFNAHKSAEDGNYSETTNAISLKNERQSRDLSVNKHGRMLLTALLENFCQLYDNNPAKSKRLFALICHTLQKIGILEEEYIEELAAVRSNYQDALHHLILQAREAIRLDDAEERLLALPDPTNVFEKFPQETALSKFSVDGLNVRQFRFRDLTLESWLQSRNSRYIEDFEEYSLLGRGGFGSVYHVRNKIDGAEYAMKKINSTFQQMSYSKIFREIKCLAKMDHPNVIRYFSSWVESTTEATQMPIVMSKNSSRVLGTSSYCDVNGMDSIIFEPTESSALTDDILFAEDPGTESIISTSRKSSYSSTTESSNFENLESPRNLHDSNVSTFNNTTILDDDYSSSMHISKTGPTHSFIIYIQMQLCFDDLESYLIRRNHFLSFPLCKEQIQLHTDLFRMIINGVMYVHEGVNLIHRDIKPSNIFLAKSLPEDRGSVPLISYNDKNDLKEYITPKIGDFGLVVENKKNTETALSFLERNHLPNLQDETQHIGTATYAAPELLDAMSSQHNKFTKKIDTFSLGMVLFELLHPFQTNMERATKLQDLRRGNLPEEFVEQHICESSLILWMTAKDPTKRPSLLEVLNCGLLLPNQVSMPNISNIVSTNHLDVETQMKLIMDENQRLREQIAVLRSRIQHLETR
The following text describes a protein:
Function:
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
Sequence:
MVSCPICSKSVSSLKINDHIDSDCQQFIEEPTSSSSDPSPSQKAPVPAFFQPSSTKKASTQRDTHSVASPLRNPSGKRPVTQNGGLDDTAARLQADEASEPVPKKPKVNAFQRAAPLAERMRPRTLDEVCGQELVGPTGVLRGLIEEDRVPSMILWGGPGTGKTTIARVIASMVGSRFVEINSTSTGVAECKKIFADAKSELGLTGRKTIIFCDEIHRFSKSQQDVFLGPVESGQVTLIGATTENPSFKVQNALLSRCRTFTLSKLTDEDIRSILNRALKTEGPNYSPSALVDDELLDYLAKFADGDARTSLNLLELGMNLSKRPGISKDEIKRALTKTLVYDRAGDQHYDTISAFHKSIRGSDPDAALYYLARMIQSGEDPLYIARRLIVVASEDIGLADNSMLTLAISTHAAVEKIGLPEARINLAHATVAMALSPKSTRAYRGLNNAFAALSEPGIAGLPIPIHLRNAPTRLMKELGYGKEYKYNPNFKDGKVVQDYLPEKLQDRKFLEDLDLGTQIDPDLESRK
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MATEAEKAQVGTHPIQETNKLISSSNVMNNERPAAWNLKGRSAVAAFDPVTRHRILQSQTMAACFHRPLMATMEDLISVSYVGGLSGPLRKPEPFICLIARVLQITPNTAIVMAMLRQDVHKYLRVAALFIIRLIGNGTAMREALRIGWNDYRKIRVYGSKDDCTCETKSQDGEKADTNEVEGEALVAAPIHAIMCVDEITDRLFNTGREGYSSTWLGVNFSPLL
The following text describes a protein:
Function:
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Subcellular Localization:
Cytoplasm.
Sequence:
MIIAFQNALDLAAELEGIGPVAQIEERVFPDGEVLVRLPEARGEVAVVARLYPAVNDNLIKLFLTIDALNDAGASKIILVIPYMPYARQDRRFRPGEPISSKTVLKLLAHLNVFGIITVDLHKGYVAEYAPRLVIKNLYPAEEFAKALGGVDVVLSPDFGSVHRAEAVARLLQVPYTYFEKYRDRSTGAITLIPRQDVDLRNKRVAIVDDILSTGGTLVDACKAAKTLGAAEVYAAITHCQLLKDARERVRSCVDKIICTDTVLNEFAEVRIGRLIRRELEALL
The following text describes a protein:
Function:
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1.
Sequence:
MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGKQLLPKTFGQSNVNITQQVVIGTPQRPAASNTIVVGSPHTPNTHFVSQNQTSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGNCSAEDLKVARSLVPKALEPYVTEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGEDDDDDDDFNENDEED
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MPDLEKELFLCCRAGHSSAEMELYIAATFCLIREWLSFHGEIKLTPCRTSLEMPPKTEMLNLNRARSLSSGQPQSSDDFDWIGSELSAPQDPIECVTDVFDGFISTNELSFLEDFGDFLGKSEEEIKTTPSRDFKFGMTKKKPRSKRRSKQRAWPMKDFVFSALENHEFRKRICTHCQIDKTPQWRIGPLGPKTLCNACGVRYNTGRLLPEYRPAASPSFDQNKHSNLHKQILRRRANLI
The following text describes a protein:
Function:
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Sequence:
MPSSQDPIQRFKRIGIVGAGNMGSMMTFAFSELGCDVSVWDVDPKNVDSVMKFAKDAQHLKGKIYGYYNIDEFTKSLEGKAERKLFLFSITHGHPADSVLGMIKHDLKAGDIILDGGNENYRRTERRQRECAGIGVHWIGMGVSGGYQSARHGPSLSPGGDAKALELVMPLLELYSAKDRKTGQPCVTRIGPGGSGHYVKMVHNGIEGGMLSTLAEAWSILHNGLGLNYDEIGDIFSKWNSDGELKNNYLLQIGADMLHRRRTPQGDYHGEGASKDDGYVLDDVLDKVVQDDDNTEGTPYWSIMESAERHVSAPTLATAHYLRVASGNREERLRVAKKLHMPIPKPIETIKDRGAFIENLRRAVYCSFLASFCQGLELISRASEDEKWDIDLGKCLQIWRAGCIIQSEAIADLLQPALTSNKRLNNMKFVDEVARELHKNFDALKEIVIEGVLSDQYMPALSATLEYLKYEGGTMLPTKFMEAQMDYFGAHAYNKPSVPGEDPGPVRKGPHHYEWKPA
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
Subcellular Localization:
Nucleus.
Sequence:
MSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTAVLGTGVGTPGYRAPVPPDPQPTSAQARNPPVTTATTQASTTPSAPAVTGTVSASAAVAAAVASFPSPDSAALRAAPGGQTTPGSQPSSGAPGSTTPNAPFPNGAGAQPGAPTMNGGAGGPPMGQPPPQMGAPNMGMNGPGGYGGYGMMNGPPGAGGPMGGNPYGQPMKKEMDQSRGPWDPQGHMYQQQQPWGGMPPQQGHGGYPNRPMNGQQTTPTGTSSVLESLINQPQQYPGHHNQMAPPGGDRNAAGGRAGVPGNPGGVPGAPQRPGAMPVNQGVMSIEDQNVYQMKLRNMRGSCDSLRTRARQCRQEGNHEAAHKLEVMLSVLEGRRVVSLEYLNHLETWIARKQDFLNINPMGGGNPGHMGMNDPVMNGDHGMMSNGQVHNPYGHPGYNHGQYGMGGPPPPHHMQMHQQQMWQQPQQQRMMPTDPMMMGGGGPMHGGPMYRGDMGHEMNSPVNSHRHNPYPSPAAMRNNMRGMQNGPGPIGRDRNSMSGSMSGPSSGAPSLNTMGTPKMGAPGSIGGLSNLDDFTYDDFLPNPIDALQPTLHIGPGSSMGGGPRVNLNDAARKELQAMEGRFEIEPNHQRHDANHIIVSAKMRNQPVPPLRLVVPITYPSGNVTVDRTAIDLDAYLYDDLQNVVHERLSRPGLSSLTDYLNAWEEQVNQYMQQNQTNGGMDAAFGVGNDFFYDNLNL
The following text describes a protein:
Function:
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
VRETETMDARWLDYPASGDLPDDEDIGEFRPRLTSDGLDIDEASGSGDYSDSEDAIYLTTMDTPVVSDNYIPGDTERKIEGEKKNTMVDNEIIPDEAVPVKENLSNKISMASTANSSIFERTEVLTALIAGGAVGLLFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA