lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Inactive metacaspase which plays a role in parasite bloodstream form growth and in parasite virulence within the mammalian host.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Lipid-anchor; Cytoplasmic side. Secreted. Note=Secreted by the parasite bloodstream form. Membrane localization is required for MCA4 processing but is dispensable for MCA4 secretion, and parasite growth and virulence in the mammalian host.
Sequence:
MGGCVSTALKVGAETVAEGHIDLISFAINYFKNAVPYIVKYLGRQQRPKEVDMEATLTEAKESKGFQPWKISCQPKGAVRGLFIGVNYGNTEAQLSGCCHDIMMMIGALQKRNFPLTEVVILADEEDVPGRTGEPTRANILRYLAWLAQDAQPNDVLFFHYSGHGTRANARDDDCEEYDQCIVPMDYVENGCIVDNEIHEILVSQLPKGVRLTAVFDCSHSGSMLDLPYAYVCDSSKDGSGSCGMKRVREDNDVQADVLMISACADDEAALGVDNTQDFYESGKDSGGAATFCLTAMMMREEPLTFLDLLVHTREMLKSRGFTQVPHLSASKPINLMQRFSLEGLFPQERTLL
The following text describes a protein:
Function:
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity); [Isoform 1]: Regulates RASGRP1 activity; [Isoform 2]: Does not regulate RASGRP1 activity.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Minor isoform; MISCELLANEOUS: [Isoform 1]: Major isoform.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium.
Domain:
The PDZ-binding motif mediates interaction with PDZ domain-containing proteins like SNTG1 and SNX27.
Sequence:
MEPRDGSPEARSSDSESASASSSGSERDAGPEPDKAPRRLNKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
The following text describes a protein:
Function:
Oxidizes histamine. Other amines including phenethylamine, tyramine, tryptamine, putrescine, and benzylamine also serve as substrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLQTTPSTPLVQDPPVPATLVHAAAQHPLEQLSAEEIHEARRILAEAGLVGESTRFAYLGLIEPPKTTRQGDVTGAARLVRAMLWDAAQSRSLDVRLSLATGLVVDRRELNPEADGQLPVLLEEFGIIEDILSEDPQWNAALTARGLTPAQVRVAPLSAGVFEYGNEEGKRLLRGLGFRQDHPADHPWAHPIDGLVAFVDVENRRVNHLIDDGPVPVPEVNGNYTDPAIRGELRTDLLPIEIMQPEGPSFTLEGNHLSWAGWDLRVGFDAREGLVLHQLHHSHKGRRRPVIHRASISEMVVPYGDPSPYRSWQNYFDSGEYLVGRDANSLRLGCDCLGDITYMSPVVADDFGNPRTIENGICIHEEDAGILWKHTDEWAGSDEVRRNRRLVVSFFTTVGNYDYGFYWYLYLDGTIEFEAKATGIVFTAALPDKDYAYASEIAPGLGAPYHQHLFSARLDMMIDGDANRVEELDLVRLPKGPGNPHGNAFTQKRTLLARESEAVRDADGAKGRVWHISNPDSLNHLGHPVGYTLYPEGNPTLAMADDSSIASRAAFARHHLWVTRHAEEELYAAGDFVNQHPGGAVLPAYVAQDRDIDGQDLVVWHSFGLTHFPRPEDWPIMPVDTTGFTLKPHGFFDENPTLNVPSSAAGHCGTGSEREHAAPGGTAVGHSGPDTGGQGHCGH
The following text describes a protein:
Function:
Has a role in mobility, possibly in the transport of potassium in muscles.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MFFYSPNVASSSSASHRRGTLTHQHHLHVGHLDTRLSVQIPEILSRNFGHHDPERARLVPEHLRFLVDENQELWTGGNQPPVGILELCAASPVDSVFSTNDARRHSQRKLILRRPTISIQEDGKIIIDHVTARWEGANINSQSALLDADDGATVITDTIKDDQEDKEPKSCPQQTVKYIKILLPHVILVSVLIGYLCLGAWILMLLETRTELLSRSKKLVRLTNLMSNFTAESWRMLSDAQHGSITMDEGEWAATFREWMVRVSETVDDRRPIRRELNRPDDLSNMHNKWTFPTALLYVLTVLTTCGYGEVSVDTDVGKVFSVAFALVGIPLMFITAADIGKFLSETLLKFVSFWNRSVRKVKQWMSRVRHGRRKSLQSTGGQNDTLDILGVDGTEEKLWFPIGAYVSCICLYCSMGSAMFINWERTWSFIHAFHFGFNLIVTVGLGDIVVTDYIFLSLIVAFVIVGLSVVTMCVDLASTHLKAYFTRIHYFGRAKRFLGMSEELKEIVALLGAMRRKKGGKVTWNDVRDFLDNELRDRPFEPHELLMKLRFIDETSSGMSTIRHNSFQSDFFRESEYIRRVAALRPEQPAYL
The following text describes a protein:
Function:
Involved in cross-regulation of inorganic carbon and glucose metabolisms.
Sequence:
MKMKLIQPFIQSIRFRIVGLLLLCLIPPTLGGIFLIDSYTGRQLKKIAEQDLQSRARLIIQLISRSDRERQQSTAFVASQPAIVEFNVEASQYFLNEFIKFHQWNGFFVVANQEGELVAGSDGANQEKGLPLKHWFEEVKDKNRHLNRLFPGKTYAESKDCLIVPIHSKNDQTQIGIVVECIPLPVIADFVQKILKDAELERILLVNYEGYIYADTDFKNYGVLENKKKSPLVNRLLNDQSGFVYSQGKFSYLSPVHLRGAKTWGLIVENSESDIQAAILNVNRIGYLLVLVIGGIVAYASWMVIHHSTVPILDLTKASQAIAAGDLDYEININQGNRQDEIGILGNSFIYMKNQIKTLIAQEVKDGVNRLELEKGRQIQQNFLPISLPDLQQWQINAVFEPARSVSGDFYDAFLLGDDYLAIVIGDVCDKGVGAAMFMGLFRSLLRVFSGETMPGDTCIRDVNYKCSANDGNGKKKVIVQFLNAVRLTNDYIATEHGDMAMFATLFFGVIDISNGNLSYINAGHEPVFILNSEGIKHRLKSTGPAVGMMPNSTFTIDSLKIDPGEMLIGYTDGVTDARSPTKEFFGRQRLMETLTANFSAKTEILDIIKQELIGHIDGSIQFDDITMIAVYRN
The following text describes a protein:
Function:
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.
Sequence:
MAIRKNSQQLTFCLFFFKVGSCFENLEQGLQGGRGVYVVAGNVVAFPVLFTPSMLIFGAAWAAGAQEFPVMPFAGSEREGKAGRGGEPVILGLGRGAGWESGQGVSMRAPLPCLLELLCAFSVASGSRRDKKFCKVAFPQEELRKRLTPLQYHVTQEKGTESAFEGEYTYHKDSGIYKCVVCGTPLFKSETKFDSNSGWPSFYDVIASDKITFTDDYSFGMHRVETSCSQCGAHLGHIFDDGPRPTGKRYCINSASLSFEPTDKNLAAEGSISSTSAQPDKTEL
The following text describes a protein:
Function:
Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Inhibitor of PP2A phosphatase SIT4, which results in inhibition of nuclear export of MSN2, due to lack of dephosphorylation by SIT4. Also required for rapamycin induced activation of expression of many nitrogen discrimination pathway (NDP) genes. In complex with PPH21, required for organization of the actin cytoskeletom during the cell cycle via a Rho GTPase-dependent mechanism.
Sequence:
MASVTEQFNDIISLYSTKLEHTSLRQDSPEYQGLLLSTIKKLLNLKTAIFDRLALFSTNETIDDVSTASIKFLAVDYYLGLLISRRQSNDSDVAQRQSMKLIYLKKSVESFINFLTLLQDYKLLDPLVGEKLGNFKDRYNPQLSELYAQPKNNKDLSGAQLKRKEKIELFQRNKEISTKLHCLELELKNNDEDHDHDELLRELYLMRLHHFSLDTINNIEQNLFECEMLSNFLKNSVHEVKSSGTQIRKESNDDDSTGFTDKLENINKPLIDKKGQVLRNFTLVDKRQQLQQKVRGYGQYGPTMSVEEFLDKEFEEGRVLQGGEEPEQAPDEENMDWQDRETYKAREWDEFKESHAKGSGNTMNRG
The following text describes a protein:
Function:
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
Subcellular Localization:
Nucleus.
Sequence:
MENETVDRAPSPAFEDDTHSVQGEDEKLDAFGDIDTNARGNSHHVNDHGEDLVDDDDLLDDDEDEDEDDEDEDEEGGSRRKRPRREKRNQFLDIEAEVDEDEEDIEEDEDEIGREDGFIEEEAGADYVTDDRRHRELDRQRQEFQSVDAERLAEEYRHKYGRSQTFRGDTSNIPQRLLLPSVNDPNIWAVRCKIGKEKDIVFSLMRKAMDLQYSGRPLDIISAFQRDSLIGYIYIEARKQAHVLAALQGVVNVYPQNMILVPIKEMPDLLKVQKKTVELLPGAYVRIRRGKYAGDLAQVDNLSENGLNARIRLVPRLDYVDAKRRHPTSRPQPRLFNESEALKNNPTKLSRRGPRQFMYNSEEYEDGFLVKDVRIASLITEGVNPTLEEVSRFHQEDEEMDLTSLAQSIKGGHADFQPGDHVEVYIGEQAGVSGVVENVHGSIVTLRSPDGLKLDVPSRGLRKKFKHGDHVKVISGKYKDDTGMVVRINKDEVTFFSDTTLSELTVFFRDLGEASTAQSINSAYDLHDLVQLDVNTVACIFSVDRDVYKVIDQNGGVRTITASQISMKHDHRRGVATDRNGSEIRIGDKVKEVNGEGKQGTILHIYRAFVFLHNRDNPENNGVFVARSRNVATVAAKGARISTDLTKLNPAISNGMPRPPAANLSRTIGRDKAVGATVRIRRGPMKGLMGIIKDTTDLNARVELHTGNKTVTVPKDSLMYTTKTGQLISYQEFVERNRGIRSGGPGGGYPGGNMPVWAQGARTPMAQAGGSRTPAWNSGSKTPAWSMGSKTPAWNAGSKTPAWNSGSKTPAWNAGSKTPAWNAGSKTPAWNSGGSNAWSTDSSRTPAWNADSSKTPAWNADSSKTPTWGNDSSKTPAWGNDGGKTPAWGADGGKTPSYGGFSAAPWDNNDDDDASKPSADAKGSAWTAPTPGGWNDDDDGDDSPKYVPPSP
The following text describes a protein:
Function:
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQEFTRIAVKVGSNVLARRDGTLDVTRMSALVDQIAELNKSGVEIILISSGAVASGRSEIHPQKKLDSVDQRQLFSAVGQAKLINRYYELFREHGIAVGQVLTTKENFSTRRHYLNQKNCMTVMLENGVIPIVNENDTISVSELMFTDNDELSGLIASMMDAQALIILSNIDGIYNGSPSDPASAVIREIEHGKDLSNYIQATKSSFGRGGMLTKTNIARKVADEGITVIIANGKRDNILVDLLQQPDDTVCTRFIPSTEAVSSVKKWIAHSEGFAKGEIHINECATDILSSEKAASILPVGITHIEGEFEKDDIVRIMDFLGNQVGVGKANCDSAQAREAMGKHGKKPVVHYDYLYIE
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MPRAILEINSERIRHNVKKLSEFSGKKVIAVIKADAYGIGSIQMAKILEPIEEVDAFAVACVEEGVELRKMGIKKEILILGGVLKDEVPLVEEYFLTPVVSDIEHLRAIGNRDIKFHVKYDTGMGRLGFLNEVIHDPRVEGIMSHLSSPADEEFSKLQIKKFEEIVKKYTKVEKIHMESSAGVVYRVPFTTHIRVGLAMYGEKPLKNYPVDIKPALTLKAKLISVKELPENYPVSYSRTYVTKKKTKTGVVAFGYADGLMKTLSNRSYLLYKGEKLPIFGNITMDMTIVDLKNTDAKVGDWVYVVNEERTFTELAREAGTIPYELMCNLSKRIKRVVV
The following text describes a protein:
Function:
Catalyzes the reversible transfer of high energy ATP gamma-phosphate group to L-arginine.
Sequence:
MAEAATIAKLEEGFKKLEAATDCKSLLKKYLTKSVFDQLKGKKTSLGATLLDVIQSGVENLDSGVGVYAPDAEAYTLFAPLFDPIIEDYHKGFKQTDKHPNKDFGDVNQFVNVDPDGKFVISTRVRCGRSMEGYPFNPCLTEAQYKEMESKVSSTLSNLEGELKGTYFPLTGMTKDVQQKLIDDHFLFKEGDRFLQAANACRYWPTGRGIYHNDNKTFLVWCNEEDHLRIISMQMGGDLGQVYRRLVSAVNEIEKRVPFSHHDRLGFLTFCPTNLGTTVRASVHIKLPKLAANREKLEEVAGKYSLQVRGTRGEHTEAEGGVYDISNKRRMGLTEYQAVKEMQDGILELIKIEKEMQ
The following text describes a protein:
Function:
Probable receptor, which is involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSTLLERTKSVQELKKRAAGKTSANPAEVAKAKKVLRRLYSWDEIPEWQRDNDFILHGYVKETSSFIETFKSLFYLHNESVNIYSHLIPALGFFTVLLLDKSTIKVFATTTWLDHMVIDLFYSGAFACLILSSSFHCLKSHSLRIATLGNKLDYLGICILIVTSMVSILYYGYFEKFSLFCLFALITVSFGIACSIVSLKDKFRKREWRPYRAGLFVCFGLSSIIPIFSGLYCYSFSEIWTQIQLFWVLLGGVLYIIGAVLYGMRFPEKICPGKFDIWGHSHQLFHFLVVIAALCHLRGLLNSYELVHIKMENGIVS
The following text describes a protein:
Function:
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDQGTAETVYDISPKLCSQQSWTGPAAAGPRPTIELVPIERKRPVLEAGLVRRNVVLTCPVHPQIRSQVNGKYDDDELMTVRYSALTCEPSGFHKERFTLRQNLYIKPRRTELLIIIPLCDESGTDLGRTLTSIFANIQYISSQKRVKTWKRHGWKRCVVCILGDGRGRLSEEAKAALTLIGLWQPALAVRDVQGQDVRAHLFEYTTCARLRDSTLQPLPECPQTPVQMILCLTERYQGPQSCGKWLSEAILPELDPQMCVFVPAGAKPSADAIYRLWERLHLHPRCGGVVGQTEMRASLLTWALNPLAAAYGVHLKLASVLENPFQSFLGFAPAFPTQLSAFRCQQERKSQDQTSGGWEAASVRDEPKSITWGSHISDRRLWAFDILSRRWNRDRLDYVRKARAHVQAPPSIDAYIVDLQHYMQDRIVFMMDSWSTMQNIEGGLRKLKFAALLIYSCLNLVVSWFAIGNTFLIFFFINHYFASDSIIGRHSSATETGLLTLYTFLLMVSVLCGLTYQPHTNRLRIIRTVITVGWILLAAYILIAIIVVGFKTTRPTFHILSNNPTDFREWFDERRFSLAILPLVAIYAIRLLASMLFLDPWIIFAAVGFRLQSSPQSNSTDAEQSIQYVLCILAHVNFINITTFMYSKLSVSEEQNTANGGIPIPTNYFVRPGNKVHLDSPSDDDLNKAYDDSLAQLLDPPDLESARLPSRKCENTSRVYPDKVVLTWALSNILLCAVILHAIPSVKGLAGDDLENMNRCPSTAYLLVIFWLIGSLEGVKFMGAILFIIKEVIYFF
The following text describes a protein:
Function:
Non-heme-dependent dioxygenase that catalyzes the conversion of 2-hydroxyethylphosphonate (HEP) to hydroxymethylphosphonate (HMP) in the biosynthesis of phosphinothricin tripeptide (PTT), also known as bialaphos (BA), a natural-product antibiotic and potent herbicide. PTT contains the unusual amino acid phosphinothricin attached to 2 alanine residues. Synthetic phosphinothricin (glufosinate) is a key component of commercial herbicides.
Miscellaneous:
MISCELLANEOUS: Mediates the cleavage of the carbon-carbon bond of 2-hydroxyethylphosphonate (HEP) to produce hydroxymethylphosphonate (HMP) and formate without input of electrons or use of any organic cofactors. Reaction was initially supposed to follow a Criegee rearrangement with a phosphorus-based migrating group. However, it was laster shown that it is not the case; MISCELLANEOUS: Phosphinothricin tripeptide (PTT) herbicide and fosfomycin antibiotic biosynthesis pathways share early steps starting with phosphoenolpyruvate before the pathways diverge after formation of 2-hydroxyethylphosphonate (HEP). HepD is involved in phosphinothricin tripeptide (PTT) herbicide biosynthesis after divergence of the 2 pathways.
Sequence:
MRIDPFKLAHWMNARKYTAAQTADLAGLPLDDLRRLLGDEANEPDPAAATALAEALSVEPSQLAADAHRNLTVVHKSAEEMHASRRPIQRDGIHFYNYYTLAAPEGRVAPVVLDILCPSDRLPALNNGHLEPAITVNLGPGDINGRWGEEITPQTWRVLHANHGGDRWITGDSYVEPSYCPHSYSLAGDAPARIVSYTAQSNISPLMTEANNWSTGAFEEALKALSGKVSAGSVLDLFLARRAHTRTSAAEAAGVPPADLEAALRSPASETGLTVLRTLGRALGFDYRVLLPADDQHDGVGKTWTTIEDSRRSRRTFGTYEAASMASAAHLPDLVGSFLRVDADGRGADLIDHAENHYVVTEGRLTLEWDGPDGPASVELEPDGSAWTGPFVRHRWHGTGTVLKFGSGAHLGYQDWLELTNTFEPAATLRRGRRDLAGWGYDN
The following text describes a protein:
Function:
Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.
Subcellular Localization:
Cell envelope.
Sequence:
MTDTDSPAPAPSPSRRSLIGWGGAGLALGAAAAAGGAVAMDRAGADADPAGADAGSAVPFHGAHQAGIATPVQDRLHFAAFDVTTEDRAAFVALLKEWTAAARRLTAGHAVGEGAYGGLPEAPPDDTGEALGLKPSRLTLTIGFGPSLFTRFGLADLRPEALADLPKFPGDNLDRARSGGDLCVQACADDPQVAVHAIRNLARIGFGKVVVRWSQLGFGKTSSTTPDEQTPRNLLGFKDGTRNIAGTEKDRLDRFVWAAEKDGTPWMTGGSYLVARRIRMHIETWDRASLQEQEDVFGRDKGEGAPVGKAKERDEPFLKAMKPDAHVRLAHPDSNGGATLLRRGYSFTDGTDGLGRLDAGLFFLAYQRDIRTGFVPVQRNLATDALNEYIQHVGSAVFAVPPGVRDADDWWGSTLFGKEA
The following text describes a protein:
Function:
Putative transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSSVKTPALEELVPGSEEKPKGRSPLSWGSLFGHRSEKIVFAKSDGGTDENVLTVTITETTVIESDLGVWSSRALLYLTLWFFFSFCTLFLNKYILSLLGGEPSMLGAVQMLSTTVIGCVKTLVPCCLYQHKARLSYPPNFLMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGLLVNLSLIPVMGGLALCTATEISFNVLGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVAMLVPARVFFTDVPVIGRSGKSFSYNQDVVLLLLTDGVLFHLQSVTAYALMGKISPVTFSVASTVKHALSIWLSVIVFGNKITSLSAVGTALVTVGVLLYNKARQHQQEALQSLAAATGRAPDDTVEPLLPQDPRQHP
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MIREGAGEVQRHLRHTLESLHDHEYFKSPRGPQERSEMDKVLRSFVFRYLYYVLSDNGRLLPHLFAGAPKDKFPTSVEDAMQVDSPSLSKADIFYAIDEITGAKSHRHTGRNCGRAFQPGEPLYRCQECAYDDTCVLCISCFNPDDHVNHHVSTHICNELHDGICDCGDAEAWNVPLHCKAEEDDSDGDEEDSVFENDYNMELFEAVLEELFDHFIEVFNQNIEPLPTIQKDLTMKLREIIQDGKTQEKFELLSALAYRNQYMEAQKPSSGPASFETEQDLDKKLDGYVVLIYNDEYHNFSQATSALRQGGPDNKHTDQLTARIDGEGRAMLKCSRDLSAVIGGFFSVQTNGLSATLTPWSEYIHQEACKYMIHWVKNCLSIPNPSFQKVFREAMGKVLCSEYIRASETTDMTPVIDKYFIPDRRNTGCHIYADLSVLGKGNVIPLGHHKVLLQESLNEIALNLNNYEELKYRRYSNSRLQQILFFDNRYWKKLRKDIRRAVIPTLASSVKYKPTFSQQVVEIFNHMTRSVAFMDREPQLSALADCVVQLFTCPTTVRTIFENENFPDIMWSVIDIFTEFSKVDDGILLWQRVQKSNPSKSYSYSFKHGLYAVETLLSKVENANLILRPPEFISIVTLCKLFNGAWRIKRKEGEHVLREDQHFILYLEYTTSIYNIIRAMNRVLDSSRAALSEDTLLQAIGLLNTFLGHRTLPYKLVQEAHDVIAFKVSKQKVAFMNPVHTLFSCLIEKVPLAKAFEAVSSTKDFLTIADFSLRAAVLCSQIDVGFWVRNGMSVLHQSAYYRTNPEINSYSRDIHLNQLAFLKENDDLPRVIYNLLDRWELLGWFTGAEQYETTVYEERITNIIQQFIAFVYHILSERHFFRYFGSSAERETHTMKNIIIYSLLMKPLPYSELLKSVPDYLSEKLSVFDECLHEVSEYVEPKGLEDSGVFSLKKEMYKKIDPLRLLNMKNDFEHSATIVKTHLAEGSNAVGQVVLQPQLISPKHLDELAAHLGDFTRTQVFAKLIYKLLQACIDREDGTYLYELLHLLHGIFKDDELLRGKSSIPEAYISKPICNLLLLIDTKANVFSENAIRKADFLLEHMIRKRHNDIFESLAAYFGQDYVEQYKAKKLNQGINFEETEKDRKKRLARLRQQKIMAKFSKQQAKFVRSNPNVITDDLFDAEVRTGSDGLVCSLCQDEESLDAFVIPAYHESSPIFFYGDYTPQNFAKPWNGFVNDDDNLTFYDDLKLYSLQEARKGSTTTFVSCNHIIHYECFRRYIQKKRFSNNLFICPLCQTFSNCVLPIPHWSLRLPKSPVTVDQLLSQPSEENLINLFIDDQTPNSTAAMNMLKEVCKKNGNYDKSYGSVSQEFVTSILTCHWANTISMIEIASRIEKNTHQTLLQGKEQKFKTLRGVLSAIGWFYKCMGTPRQKFVPYVFHGEDDGPANQVFQYIVHKSLFSGAPVSETISHALAIWIRTLATQFLISSNKTGYEITYHQAVSLGPVYEAPPEFTTACSSLDQIIAIEDTTLKTKMVDLTYTMLMKTLLPTLRRCMIMLYVFSGLLSAESCLRIDGLDLSADLPFEDLPSYFQKLVTLLCKTGFVSIFNRSTIETMDHQYLRNIPMEYAGTVKLVDLAKYLNTYVTNTKQLKLRDEATSMQSRNIKNRLDFKICLTCGVRVYSRSDGTEIMKHMAKNCFKAYSLFLIPHDSEVRLVLQHPHSHISIPAPYLNSHGESGKNAIQRGDLTTLNIHRYEHLNYLWLNNEIPGYISRIMGDEFRVSIISSGVVFNFDRNVLRRQMRANVGNEESSEEEDLMDDDEMSPDDDPDFRWEVTPEEFFRDGILRLGGAPGQGGDIRDFFQFITNLRTDDRNDNIPTFQFTNGALGRNQNDDDDQDGDEILP
The following text describes a protein:
Function:
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
Sequence:
MTDTGQIPGEGLPENAGMVEQPGVPAPGAYTYLSEATAEDEDLLLLPGAQSAWGNEVAPPAPEPVVETVHQPGPHEMSGRDSGSVDLGGVRLPDPAQDSATAPVPARRPLHLGPPIPDTSASPVRSLADRGPADAPVRHPGPPTACPEYLDVPQAAVPTPQAAAPWGAQTAPQAQEVPVNAGAGHAETVVPVPEQQAAEPVGAAQALVTRVATEAVAATGGTPADAGESGEPQEAPAPEAAHTDAGWPVDPAEEAVPVPEAVPAVPVAPTAPVTEPVQATAEDDAGPEEALAVPEAQEVPAQSAPEEAPAEVPAEVPAQAPQGLDEPRVADDAPEAPAPQEAPSSLAPEPTPGDARAVDAPVAAAEPEASAPEAAAPEPSVPEAAEPGPAPSPAPEQPAPVQVEAAQPTPPEARPAPEAAPHPQPDVQPAPQPAQGPQSLMDATMQQEQEQEQEQEQEQEQEMAAVVVTDGTAGPVAADAPATGAQEPAPVPAPVAQEPHPAQPVGQFLPVDGGQVPTTPHLAPTPPEAVLVPPETAAEPEPVAAAPAAEEAVAPVPAPREADPELVQSVDDLDTRGAEEDDHAAEAAEAAEAAEETAEAVGATASDPASQEAPAPQEAPHDGSSGGAAEAPRPVGPAAPAYDDAERAAVLKVMRERRDIRNGFRSDPIPHEVLLRVLEAAHTAPSVGHSQPWDFVVIRSADTRRAMHELATRQRDAYAKSLPKGRAKQFKELKIEAILDTPVNIVVTADPTRGGRHTLGRHTQPQMAPYSSALAVENLWLAARAEGLGVGWVSFFDEREMVRALGLPEHLDVVAYLCVGYVDEFPDEPELMQAGWSKRRPLSWVVHEETYGRRALPGEAPHDLLAETVAQIRPLDAKALGEAWERQKRMTKPAGALGMLEIISAQLSGLSRQCPPPIPEPAAVAVFAGDHGVHAQGVTPWPQEVTAQMVANFLGGGAVCNAFATQVGAEVCVVDVGVATDLPATPGLLPRKVRAGTSDMTTGTAMTREEAKQAIEVGIETARDLVAAGNKALLTGEMGIANTTASAALISVFTGADPAEVTGRGTGINDETLARKTEVVRRALELHQPDPADPIGVLAAIGGFEHAAMVGLLLGGASLRTPVILDGVSAGAAALVARAIAPEVLAACIAGHRSAEPGHVAALNKLGLRPLVDLDLRLGEGTGALLALPMVQSTARAMHEVATFDSAGVTEK
The following text describes a protein:
Function:
Involved in biosynthesis of fatty acids in mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MSAILFPGQGVDWKTWMQPYLENNIVQNTLKEAENVTEIEIRKYIVEAEAKSNLRQPITTIAQPAILACSIALLRAFPPFTKKFRFYVGHSLGEYSAFVASQTLSFSSALKLVQARAKAMSYASALCQNPTSMLAITLTSRFPTDNFLNTVYSAVQKYRLIDIANVNSDRQIVLSGDKKELESITSTLSELVRSLGKLRSNWLDVSGAFHSRYMLPARDSLKNALGETEFNISPELCYTDSGKRFLPIISNVTAELYPADEEDIRRQLLLQCFRPVLFKNCLKTVKSKYGANLFYAYGPGTTMQSIAKQNGISTKSRP
The following text describes a protein:
Function:
Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNASGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFIWKRPPEICENPRFIIDGANRTDICQGDLGDCWFLAAIACLTLNQRLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIRDAPSDMHKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLFRDSDLDPRASVERPTRTIVPVQYETRMACGLVRGHAYSVTGLDEVLFKGEKVKLVRLRNPWGQVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNRQHLQKDFFLYNASRARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQEQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MEPRRMADSLRYVLMGTGPFAVPSFEAIRQQMDSTGDQIARVFVRPLPPVKSRGGPPPQPVREWAESHGLPVDAPASINDPETIASLTELNADLLVVCDYGQILKPDALQSARLGGINLHGSLLPAYRGAAPVQRALLSGDRETGVSVIHMTPRLDGGPIVASRTTPIRDDETSGELEVRLSEIGVDATREAIGLLRTIESLDSHGPLGEPQDPAKVSKAPRLSKAEAQIDWSATGREIDCLVRGMQPWPVAFTHTVVNENKPPLRVAIRGVRTETYAADASNIGRVMEHEGLAIGCGDGQVVIERLQPAGKKEMSGLDFKRGHRLTAGQQLIAP
The following text describes a protein:
Function:
Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.
Sequence:
MNQKREVTSVDLVALTAELNEYAGAKVDKAYLYGDDLLRLKMRDFDRGRVELLVEVGETKRAHVADPTHVPDAPGRPPNFAKMLRNRLSGADFHAVRQHGFDRILEFEFRREDADTTIVAELFGDGNIAVLDPQREVVDSLDTVRLQSRTVAPGRDYGFPDARVNPLDLSYEAFAEQMRDSDTDLVRTLATQLNFGGLYAEELCSRAGVEKTTPVADAPESTLEALFDASETLLGNISAGDLDPQVYYEPTDDEDEQGARVDVTPIALDERADLPSDAFESFNDALDDYFTNLDTSEDEDSGETVDRPDFENEIEKQQRIIEQQEQAIEDFEAQAEAEREKAESLYGHYDLVDGLLSAVRQAREAGHGWQQIADTFDDAAGDVPGAEAFVGVNESAGMIRARIDDHTVTLDPSAGVEKNADRLYTEAKRIEEKKAGARAAIENTRADLDAVKQRRDEWEAEPESEHEDDADDEVAWLSRSSIPIRHQEQWYERFRWFRTSEGFLVIGGRDAGQNEELVKKYMDRYDRFFHSQAHGGPITVLKTSAPSEPSNDIEVPERDARQAARFAVACSSVWKDGRGAGDAYMVSPDQVSKTPESGEYLEKGGFAVRGDRTYFRDLSTEWAVGITCEPNTRVLGGPTDAIREQVETRIEIEPGRYAQGDAAKRIYREFRERFTDESFVRKVASPGEIQKYMPPGGSRIVEE
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MISVKCLIGQILINSDNPSLNKFKCQKCMEFIFFSPTYQCKLGHWRCQSCWQERLNTFESRCFECDNIIESIEDLSRNIFIEKEFSQLQACCPNSYNGDHLNPINNIIQNNNNNNKKDNNKNKNKKNKNIFNKEKEEEEIDEKIIDFDKLYPQEAKALQTIAIEDQYNLNDENEEDDEEDQDEDENGEDGDGDGDGDDDDDYDDETIEERIKDVERGCPISTTVGELKSHLEICQFRFQKCKNEGCIEIKRKNDLEEIHYDINNELNGCKFNLMKCNDCKRDDIQKRYYQSHLLSCPKKVINCLHCDDQFERSHWPQHEYTQCKQRVISCTFKAGGCNQRFKRLHLPHHLKSINHIEFISKQYDSQLFEINLKNNLLLSKLNSISNENSIFQIQLKKQQKEEEDEKQKQNQHQHQPLQLQLQPVFEYKNKWRIPSFKCYPIAKAGLLNLKNKKVQNINYTSEPFEIGPFKFLFSIDEMADYEDGPSLHFYISPIDLGNQLKLEYSIKLLNENRKMIKYEGERLFTSLDRELVGDTLKSDIELGKDEILEWGIELRTVEVHEPLQETKAIKNNNKIWK