lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription activator that mediates abscisic acid (ABA) signaling. Binds specifically to the ABA-responsive element (ABRE) of the EMP1 and RAB16A gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDLKDGGGSERRGAAAGAGAGAAPLARQGSIYSLTFDEFQSTLGGMGGGLGKDFGSMNMDELLRSIWTAEESQAMASASAAAAAAEGGLQRQGSLTLPRTLSVKTVDEVWRDLEREASPGAAAADGGGGGGEQQQPRRQPTLGEMTLEEFLVRAGVVRENTAAAAAMVAAAAAPPVAPRSIPAVNNSSIFFGNYGGVNDAAAAAAGAMGFSPVGIGDPTMGNRLMSGVAGIGGGAITVAPVDTSVGQMDSAGKGDGDLSSPMAPVPYPFEGVIRGRRSGGNVEKVVERRQRRMIKNRESAARSRARKQAYTMELEAEVQKLKEQNMELQKKQEEIMEMQKNFFPEMQKNQVLEAVNNPYGQKKRCLRRTLTGPW
The following text describes a protein:
Function:
Probable glutamate transporter which transports extracellular glutamate into the cells. Regulates the production of intracellular reactive oxygen species (ROS) probably by controlling the synthesis of antioxidant glutathione. By regulating ROS production in blood cells, required for maintaining bacteria phagocytosis following infection with S.aureus and possibly E.coli.
Miscellaneous:
MISCELLANEOUS: The name 'polyphemus' derives from the Cyclops in Greek mythology that failed to guard against Odysseus as mutants are unable to defend against microbial infection.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEPKSQDQAPNRDDPDLQTEPLTIAQSITSFYMYNPYEKRSVEVPLTNCDAFISLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGPKWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEIGDHYIERYNERYYVLVACLLLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFNGLPNINDREMVTPPVEWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWKLIRDILLILIGLIFGIVGCTVALMQLIRDFQLTLNSM
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MFSEKLITFKTSDGEEFKLNESVRSEVMKNMVQDVDSTSNVIPLPIVDGKTMTKVVQYWKKYSEEGVTEDQLKSFDQDFLKMSQSELVGVLLAANFFDDKQLKEIIIQEFADRIKGKPIEEIREVFGIVNDYTPEEEEEVRRENAWAFE
The following text describes a protein:
Function:
Proton-associated glucose transporter in the brain.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLQQQRRAGGGRAGTRAAHGAGRNPASERDASWLEPQEHPPAPPTMIAPASSTPPGEALFPSLAPQDFWRSQISSYSGSVTRHISHRANNFKRHPKRRKCIRPSPPPPPNTPCPIELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGTALADTATNHKWGILLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDQTSFGRALGGQLRVVYIFTAVTLSITTVLTLVSIPERPLRPPGEKRTAMKSPSLPLPPSPPILCEEGAGQTLPCHSATSLYASFSSPISPLSPLTPKYGSFISRDSSLTGINEFASSFATSNIDSVLIDCFTGGHDNYLAIPGSVPRQAISVSFPRAPDSFYRQDRGLGERREVALAAGPDGDVLRVGSLDTSKPRSSGILKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSEPAGQPLSMRHLCFTICNMPKALRNLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPRAPHASEEYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEYLSIRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVVYEIPPSDTTDEEHRPLLLNV
The following text describes a protein:
Function:
Member of the two-component regulatory system YcbM/YcbL. Probably activates YcbL by phosphorylation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRDSAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLTVILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITKVHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYGAAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGLTITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.
Subcellular Localization:
Nucleus.
Sequence:
MGGTDAKDILGLPKTPLSLTQEKKSRPQKESHRKPDGISREVYALTGGVAPLMPSIDLKRRPPADEKVAWKWLSFTNSARKDDLQLYHWVRVVNDVPPTGDYSFAKYNKSVDILKYTDEEYENHLTDSVWTKEETDQLFEFCQNFDLRFVVIADRFPVSRTVEELKDRYYSVNRALLRARAQSPADVANHPLMKEPYDITRDRERKRALSMVLSQSRHQEKKDAEILAEAKRITEMRLAARRAEEPDVSANENAGLDKADGVVPGRSVSPTSNSQLPATAVAPSTLTMADYASTLASLRMLHVYLRTYGLEQMVQAASSAVGLRTIKRVEQTLQDLGVNLKPKVPTKTVCDEHLELRKEILTLLNLQKQLQYKESEGSSHREGSYAAMPDTPKDRVFAPDPFSFGAERPIKKEQKRKGPGRQADTPSPAHKRPRKLKASDL
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MENLIALLVAAPLLGAVVLLCGGRRLDRVGHWIGTLLAAVSFVLGVVLFADLLGSGAEDRTLTQHLFSWIPVEGFQADVAFRLDQLSMTFVLLITGVGSLIHLYSVAYMEHDERRRRFFGYLNLFLAAMLILVLADNYLLLYVGWEGVGLASYLLIGFWQHKPSAATAAKKAFLVNRVGDMGLSIGIMLMFLWFGTFAFGPVLGGHGEAGLAAGADEGKLTAIALMLLLAACGKSAQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGAIFNGAPDAQLVVTIVGAVTLLFGAIVGCAKDDIKKALAGSTMSQIGYMVLAAGLGPIGYVFAIMHLVTHGFFKAGLFLGAGSVMHGMNDEVDMRRYGGLRKYMPVTFVTFGLGYLAIIGFPGLSGFFSKDKIIEAAFAKGGTEGWILGACALLGAAITAYYMTRVMLMTFFGEERWRNAPTPSPAKPDVEPAAETRGTYEPPHPHESPGLMTIPMIVLAVGSVGAGAFFSIGDRFMHWLEPITGHSHGDSPISAGAVTGATVACMVIGVAVAWAQYGRRPVPAVAPRGSLLTRAARRDLLQDDFNHVVLVRGGEHLTRSLVYVDHTVVDGVVNGTAASVGGLSGRMRRLQNGFARSYAVSMFGGAALLVAATLLMRAV
The following text describes a protein:
Function:
DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTFQELGLSQEVMKAIERMGFEETTPIQAKTIPLSLQNKDVIGQAQTGTGKTAAFGIPIVEKVNVKNSAVQALVVAPTRELAIQVSEELYKIGAVKRVRVLPIYGGQDIERQIRALKKHPHVIVGTPGRIIDHINRGTLRLEHVHTVVLDEADEMLNMGFIEDIEAILSHVPAERQTLLFSATMPDPIRRIAERFMNEPELVKVKAKEMTVPNIQQYYLEVHEKKKFDILTRLLDIQAPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLSQAKRLSVLRKFKEGAIEILVATDVAARGLDISGVTHVYNFDIPQDPESYVHRIGRTGRAGKTGVAMTFVTPREIGQLHHIERTTKRKMERMKPPTLDEALEGQQRIAIEKLLNVVETENLSFYKRAAEELLEEHDSVTIVAACLKMLTREPDTTPVQLTEEPPLAVKREKKRGGRPDGSARSRTKKRRITAH
The following text describes a protein:
Function:
Regulates arginine biosynthesis genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MLGKEIGKDQRQKRIQDIILRESVSTQAELVKLLAKEGVQVTQATVSRDINELRLVRVPIGKGRHRYALAQYGGDSDIEEQLARLFQSFVQDVDRGENILVIRTADGHASGVALLLDRWKRDDIVGTLAGEDTIMVVARSTHDGESLMEEFNALMLG
The following text describes a protein:
Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
Subcellular Localization:
Cytoplasm. Lysosome.
Sequence:
MCKEMAQVAGRMKNPSIVGVLCTDSQGLSLGCCGSLSDKHAGVISILPQYAAKLTSDPTDVPVVCLESDNGIVMIQKHDHLTVAVHKVTS
The following text describes a protein:
Function:
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MNFLRGVMGGQPAGPQPSGAETIQKLCDRVASSTLLEDRRDAVRALKSLSKKYRLEVGTQAMGHLVNILQADRSDSEIIGYALETLYNMISNDEEEEPEESEDGDSSGLGKRNSKSVMLEENSQKQADDLGVQFTEIFIKEQENVTLLLSLLEEFDFHVRWPGVKLLTALLKNQCAQVQGVILVSPMGVSRLMDLLADSREVIRNDGLLLLQQLTKGNAAIQKIVAFENAFERLLDIITEEGNSDGGIVVEDCLLLLLNLLRNNSSNQNFFKEGSYIQRMKPWFEVGDDNSGWSAQKVTNLHLMLQLVRVMVCPVNSPGATSSCQKAMYQCGLLQQLCTILMATGVPADILTETINTVSEVIRGSQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVATLLPSTIDANSISAGQLLCGGLFSADSLSNWCAAVALAHALQDNLTQKEQLLRVQLATSLGNPPVSLLQQCTNILSQGDKISRRGSKVQTRVGLLMLLCTWISNCPIAVTHFLHNQANIPFLTAQISENLGEDERLVQGLCALLVGICIYYNDNSLENYTKEKLKQLVEKRIGKENFVEKLGFITKHELYSRAAQKPQPTFSSPEQMLFDHEFTKLVKELEGVITKAVHKSSEEEKKEEEVKKTLEQHDSIVTQYKELIREQDTQLNELKEQVSSLKTENEQMQATITHQLSQIQQHKDQYNVLKLKLGKDSAQQLSAQAEGAQVNGLQSEELTGLREEVEELRKQHAELQVQLREKDALIDKLRSGPAPPVEGIATSSENNAELLKELETLRSKVQSQTAEIGQLQAERRDLLKKVETCSAMVSVPTAAGSTDGAGDSGKIAELESRLVALMGETEKLKEEAKSSLESRAGLERQLAEANSTVAILQTEKAKLQQEVADSKKEQDDLLMLLADQDQKIQTLKSKLKDLGEPVRGFYSGFALCENGMLIHGSIVIH
The following text describes a protein:
Function:
Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Located throughout the nucleus, excluding the nucleolus but enriched in multiple speckles.
Sequence:
MVIESEINDKKRGLESSSPTINDPKKVKVESPSSGKEDGEVDEVTSSPASRETSSSKLMSPSKNQSSSSSRSYHDSNNGYRRKDERYSSSRSYDRNYRDRDISRDGDRERDRDRERDRDRDRDRDRDRDRDRDRERDRDRDRDRDRDRDRDRDRDRERERERDRDRNSQERGSRNSHERDYRDNRDYSRDSRDNMDSRDNKNGSRQSINNNTLSYEKQADRKDEVRVKDNISVNDDKTNHGENLTNESITATSTNEPTKPAVIIEEDEETKTKRILEENRLQRQLIMEKYNKEQPQPITSSLSTTEKEQSNTNTNSNSTPVATTTTSILAKSPSNLENQIEEEDESIIIEWRKDQNSENSSAFNDNNNDESCSSEEDLKKRGKIKEEDIKAKDKPITTTTTTTTINNVSIKLPPKPEPIKAKTSAPVFDMFSDSPSDETDESNRDLNETNGGGVMVDANIVVNPSINLSDNWDDADGYYKFRVGEIMDKYQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSMSLHQLIKKYGKDIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKNTIKIVDFGSAGEIHESEITPYLVSRFYRAPEIILGHKYDYSIDVWSVGCCLAEFFTGKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKSEFVSNHFNENLVFMKQEIDNIEKTVRKVPHDITKPTKDILQFLLPKNVSIPDQDMKKLIQLKDLIEKCTILDPEKRITPFEALNHEFLKPF
The following text describes a protein:
Function:
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable). Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with the chloroplast NAD(P)H dehydrogenase/photosystem I (NDH/PSI) supercomplex.
Sequence:
MAHFIDLNSLTNTLPSLPKLPESRKTGKSSGFACRRTEEFQEPDSVQITRRMTLGFAVSIGLTGILGENNVSLAQDNGFWIDGPLPIPPIYNNIVNEKTGTRTFIKKGVYVADIGTKGRMYRVKKNAFDLLAMEDLIGPDTLNYVKKYLRLKSTFLFYDFDNLISAAASEDKQPLTDLANRLFDNFEKLEDAAKTKNLAETESCYKDTKFLLQEVMTRMA
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MVEQQQQQEEDIWGQILRESANKNNYFESRHVAILGDPTSGKSLLLSKFDTITDDKDLKSIALSYTFSDIYEDDTSEDPIGRINYWSLEGESSQNDLLKFALSKENIENSMVIITLDFSQPWLLVESLKKWLGILEEHIKSIFKDDKNGLRKLQDKLLVKWHQYVEPQSQQTSQQQQQQQQQQNNTANPINTPIQKKKKKRVNASYQDGDASVLPPLSENILINNLGVPILVACCKSDSVVMLEKDFDYKDELFDYIQQYLRRICLQYGAGLIYTSAKKEINCDVSLEYIENILFGFELKSKTQLIEKDQIFVPAGWDTLAKIQVDFDNQKVCKDADEPYENIVKKPSIIKRREMTQNNLLIADEDQEFLSKIKSMLDKDGDGTDAGLSSISPTPTSPAISQPSQNSSQPQSSQSQQPNTTSPTNPLRVSSGNVSGTPVAASPSAERAALANFFTSLISKDKTSSRKDIKSSLTSPPTASTSSSNVRGDAQKELEKLKQQKK
The following text describes a protein:
Function:
Involved in the pathway of N-acetyl-D-galactosamine degradation. Catalyzes the conversion of N-acetyl-D-galactosamine 6-phosphate to D-galactosamine 6-phosphate and acetate. It can also catalyze the conversion of N-acetyl-D-glucosamine 6-phosphate.
Miscellaneous:
MISCELLANEOUS: In Shewanella sp., the active phosphotransferase system (PTS) specific for the transport of GalNAc and GalN is replaced by a set of GalNAc- and GalN-specific permeases and kinases (AgaP and AgaK, respectively).
Subcellular Localization:
Cytoplasm.
Sequence:
MKPNTDFMLIADGAKVLTQGNLTEHCAIEVSDGIICGLKSTISAEWTADKPHYRLTSGTLVAGFIDTQVNGGGGLMFNHVPTLETLRLMMQAHRQFGTTAMLPTVITDDIEVMQAAADAVAEAIDCQVPGIIGIHFEGPHLSVAKRGCHPPAHLRGITEREWLLYLRQDLGVRLITLAPESVTPEQIKRLVASGAIISLGHSNADGETVLKAIEAGASGFTHLYNGMSALTSREPGMVGAAFASENTYCGIILDGQHVHPISALAAWRAKGTEHLMLVTDAMSPLGSDQTEFQFFDGKVVREGMTLRDQHGSLAGSVLDMASAVRYAATELNLGLSNAVQMATRTPAEFIQRPQLGDIAEGKQADWVWLDDDQRVLAVWIAGELLYQAEQARFA
The following text describes a protein:
Function:
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
Subcellular Localization:
Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
Sequence:
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL
The following text describes a protein:
Function:
Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Predominantly nuclear.
Sequence:
MESGTVLLESKSSPLNLLHEMHELRLLGHLCDVTVSIENQGVHEDFMAHKAVLAATSKFFKEVFLNEKSADGTRTNVYLNEVQAVDFASFLEFVYTAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQLKKQMLESVLLELQNFSESQEVEASSGPQVSVTPSSKASVPGEDAHSNGLVDSSDYPIERLGNGLSPETPSKKCKEKLDKKKDVAKPPFPKIRRASGRLAGKKVFVEIPKKKYTRRLREQQKSAEEAAENDKCPQDQSPDNERMETEPAAKSEACPASVELEESLQKVEGEKEEEEGKDGEEKKKSNFQCTVCDKAFLYEKSFLKHIKYHHGVATEVVYRCDTCGQTFANRCNLKSHQRHVHSSERHFPCEMCAKKFKRKKDVKRHVLQVHEGGGERHRCGQCGKGLSSKTALRLHERTHTGDKPYGCTKCDAKFSQPSALKTHLRVHTGERPFVCDECGARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKEYLKHHNRIHTGSKPFKCEVCLRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQVNALQRHHRIHTGEKPYMCNACGRTFTDKSTLRRHTSIHDKNTPWKSFLVIVDGSPKNDEGHKTEQPDDEYASPKLSDRLLSFGENSHFNNLLEVQGNVPAVQENSSTGAACKAVVSQDALLTTSISALGELTPQAVSMPAHLPSLTNME
The following text describes a protein:
Function:
Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence.
Subcellular Localization:
Nucleus. Membrane; Multi-pass membrane protein.
Sequence:
MTKRDRTIYSCDACRSRKIKCNRQTPCASCHKSKRDCVYTVSRQRDAQITNRKLDKKTYHQISAIEKKISALEGKKGLLQVETINFNKSFTDQTPLVELQSLFPYLLLSKQDPGCVLVRHHCHHLLEKDPRYFEYSQLLADLSLTKRHHLTARAKALLGEAYIPSPQEGHTIDQLKHVLSLNPNFRFAGNFADPLTSFFSLIPPAWANKQLVDTFFQHIYPVIPIIDETDFNTSINRVLGPQIDGHYINSFPSIGSADDLPFLALFLLVLRISYMYTPGACPVSYDTLRAAETIMKEFDITKTHSLTALQAEIMLRFYKIVAPESYTQSNYVQVSVGVLIQNCYSLALHRDPEYIGEHNPKQQHLRRKIWHLLLRMEVIDSAIFQTILSSNPDASDTKLPQLIDQAPPMEQSIVKHIWRSTDLFVSLRKLVEINSKTSEDTPLETVLELLVEVETKLQAFLATIDSEASTVFYNDLVIFSVNFLLVYMYYSLYLFKGPTPLGNKYLLKSAQILFVDLARTRSTSLFLAYFNLNYIHLVLMITNFLRMRVDCIIHRHLRAQDSSVQDLQCCRYFLKIIFFSHVKELGNYSSSHKYAWQMRKVYLTLAKIMERSSDVLISNDPELVKSAAVDIPVKEINKLLEQYINFKGFTPTTLFDPTDNELIDEMQHENLWNAMENIEYSEKVYSGWIDAIKNVPSNWDWDYWDFLKIS
The following text describes a protein:
Function:
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Sequence:
MILVLAESALELVPKEIWNHPAVLADARRRGKRPGEILLDRARHHPAMRLLADAKRRGRPDIVHQVLLAFQYSLLAKRGLGKAYIHTRDDYVIAVSPEARVPKNYNNFVALIEQLFALGKVPPKGEPLMELYRKDLATLLQELGGVWAVFHESGARKPLSQMGSELLKSVVVVGGFPHGDFQNKWVVEKAAVVYSLGEESLDAAQVICKAVTAAEVAAGLL
The following text describes a protein:
Function:
Negative regulator of cell death and defense responses. Exhibits calcium-dependent phospholipid binding properties.
Miscellaneous:
MISCELLANEOUS: Overexpression of BAP1 can suppress a defect in BON1 and confers more susceptibility to virulent pathogens.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MIYFGRSIDNHYTTMMTKTLEIDLRSAEGLKLNRRPIKKKTFAVVKIDEKCRKSNLDESRRSNPTWNYKSEMPINGNEQFIFIEVFYRTGSGHDKKIGEAKIPTNDFMGRYSPEGHLNFLSYRLRDEFGDKCGIVNLSILVKSDPTRDYGACSSQAAVTGLWRPRLETASIDGYGGRTVTGVPVWGLYQRQF
The following text describes a protein:
Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKMLLFVVWALLALILCPVHISGVAEESFEVSVWPNQALVEFGQSLVVNCSTTCPDPGPSGIETFLKKTQVGKGPQWKEFLLEDVTENSILQCFFSCSGIQKDTSLGITVYQPPEQVILELQPAWVAVDEAFTVKCHVPSVAPLESLTLALLQGNQELHRKNFMSLAVASQRAEVIISVRAQRENDRCNFSCRAELDLSLQGGSLFQGSSPIKILRIFEFSQTPHIWVSSLLEVGMAETVSCEVARVFPAKEVIFHMFLEDQELSSFLSWEGDTAWANATFRAMEAGDQELSCLASLGPMEQKTRKLVHSYSFPPPILELKESYPLAGTDINVTCSGHVLTSPSPTLRLQGAPDLPAPGESAWLLLTAREEDDGRNFSCEASLEVQGQWLMKTTVIQLHVLYKPRLEESSCPGKQTWLEGMEHTLACVPKGNPAPALVCTWNGVVFDLEVPQNATQNHTGTYCCTATNQLGSVSKDIAVIVQGLDEGISSALFVVITVALGVGVITIALYLSYRPCKVDGRKLLSRQKEEDKEEKSQFTVEEEKSTTHIIDSYLME
The following text describes a protein:
Function:
Induces host cell G0/G1 arrest and apoptosis.
Subcellular Localization:
Host nucleus, host nucleolus. Host mitochondrion.
Sequence:
MMPTTLFAGTHITMTTVYHITVSQIQLSLLKVTAFQHQNSKKTTKLVVILRIGTQVLKTMSLYMAISPKFTTSLSLHKLLQTLVLKMLHSSSLTSLLKTHRMCKYTQSTALQELLIQQWIQFMMSRRRLLACLCKHKKVSTNLCTHSFRKKQVR
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGEDGEGDFLVVGSIRKLASASLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEEGSGDEDSEGLGLEEYDEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGMEEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPLFKDKGGPEFSSALKNSHKALKALLRSLVGLQEELLFQYPDTRYLVDGTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFTVYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPESLPGEPEILPQAPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDARTELYRSLFGQLHPPDEGHGD
The following text describes a protein:
Function:
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides.
Sequence:
MAENGSLSEFLTVAIDVAKQAGEVIRKGFYQTKIVEHKGSVDLVTETDKACEDLIFNHLKQHFPSHKFIGEETTAANGVSQLTDEPTWIVDPLDGTTNFVHGFPFVCVCIGLTVKKVPVVGVVYNPIMNELFTATDGNGAFLNGNPIKVSSHSELVKCLLTTEAGTKRDKATLDATTNRINSLLYKVRSIRMGGSCALGLCGVACGRNDLFYEIGFGGPWDVAAAVVIVKEAGGVIFDPSGNDFDITAQRVAASNPLVKDAFVEALQQSA
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
GNFPEFTRPKNVGSFSLDIHRNYVNDYSELRYLSMPPEASTSGSCKVNFDLKRGVSRVVEKDEESIRQKMLDDLLRWILQERKAEHKNIIDHQHPLRPLLVEFVCYRGLLTLLIETPYECQENWTILATRFQNSIYLWQLKESKKQNGSIAVQKEKSIWGFKFEQYLCASSPNGNPNPNEQVNTNAEFCCVLKTRIGGLPLLYGAEVDAVTKESQPPFLDLQNFVELKTNKHIGNEMQQAAFNRFKSMKWWAQSFIVGIPKIVVGYRDDDGIVSRLETMDVNQLRKQSTDCWKSNICMNFCLKFLKFVKECIPKDSTSNDHFLFEFDAMSRVISFRNELGETRSRNLLPSWYVESMQKSA
The following text describes a protein:
Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRTRPNFLITGTPGVGKTTFSEILAERYNLVHIPVSRLIQDKHLWQEKDEERDCTIYDEDLLDEAIKEILDSNPEGGVIFDFHCSDIVMLDDIDYVLVLRTNSDILYKRLQSRGYSESKIQENTECEIFRVVLDEVLEGFEELGEDHIIEIQSDTMEQLDEAVMNVGHLIESYQQQE
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Subcellular Localization:
Mitochondrion.
Sequence:
VVKKRRDKVNPGEVIVEIETDKATMEVEAVDEGILAKIVIPQNSQNVPVNSLIAVLSEEGEEKTDIDAFIAKNNSVSPLPKTDTNLPKPHENIANVEEQGAVIKHDTSKIFTSPLAKRLAKMGNIRLESVKGSGPHGRIVKQDILSYTSSTVHNKIVSRNPEEYRLVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKSFSEDKSTKISVNDFIILAVAKALQEVPNANASWGEDAIRYYNNVDISVAVAIENGLVTPIVKNANQKNIIELSREMKELIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFNAIINPPQSCIMGVGSSSKRAIVKNDQITIATIMDVTLSADHRVVDGAAGAEFLAAFKKFIESPALMLI