lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
3'-5'exoribonuclease which is involved in the post-transcriptional processing, editing and degradation of mitochondrial RNAs, including mRNAs, rRNAs and guided RNAs (gRNA). As part of the mitochondrial 3' processome (MPsome), involved in the maturation of guided RNA (gRNA) precursors by catalyzing the processive 3'-5' degradation of uridylated gRNA precursors. Plays a role in the degradation of 12S rRNA processing intermediates and maturation by-products.
Subcellular Localization:
Mitochondrion.
Sequence:
MTPRRVAKLVQFSGSYLNTEWARKFILGSLLQRYNPQSLTTVGSSAAGNSGEDASLDKELLHLQRSLSEVWSLPAQPLDAVSEGRILRLLARYATGEGVMSIEALNELSHVLSCIRGSPQRVEGPIDMEELLLAIGYAKPGDNLRRVAFAGELQYPPSALAHMRAHLRDDMERDGSDPFDILRVVTHNPAYAIDSASTSEVDDAIGVHKDPVTGEECFVVYVSDATVYCPFDSPLEQLTARLLTTTTYLPEGVFFMLPKPIVDAATLREDRPCRTFDIRFQIDEVTGELKNYSVGVGWLHKLRRITYDEVQALYDEEAQVGNQHHHTERESTQASPAKREEGKKGMVASGGTSSCRPSWMTVEDESILRRIYRAAQKRYETRQLRAGDRFIHADLPEPLIKVGAGAQVLSVEDQIIGTRDARLAVAEMMIAANEVCSRVAQENHLSIPFRGTRELSLDHVAAKSYREPHGVVSVQSLDPQYVFFAEAMQRSIRQLSGVTRAVYFHTPIYHAGLDTHNYTHSTSPLRRYADMLVHHQLKVWLWRTSHCSSGGGVLHSAQKSSPVLIEQPIAEHTMATLCSMISSKQEQSSILQESSQRYWLLKHIKQNILTKSPHHRFICLVGDTRSVKCAPEYARFVVECSHDSPSQPDGGVHRTVPWAGRWKQRHHEYLYVSDIYITELQFAHVVLHSLPDVVVGAVVECEVREVHPTQGYLSLAIVKVWSGGDERRFEPLWKKCLLPSLDS
The following text describes a protein:
Function:
Glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Required for addition of mannosylphosphate in yeast mannan. Recognizes any oligosaccharides with at least one alpha-1,2-linked mannobiose unit.
Miscellaneous:
MISCELLANEOUS: Present with 4380 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MHVLLSKKIARFLLISFVFVLALMVTINHPKTKQMSEQYVTPYLPKSLQPIAKISAEEQRRIQSEQEEAELKQSLEGEAIRNATVNAIKEKIKSYGGNETTLGFMVPSYINHRGSPPKACFVSLITERDSMTQILQSIDEVQVKFNKNFAYPWVFISQGELDGMKQEMIRQAITDSMNGDPELINIKFAEIPADEWVYPEWIDENKAAESLISLANVPDGDSRAVRYQARYFAGFFWRHPVLDEFDWYWRVDPGIKLYCDIDHDLFRWMQDEGKVFGFTLSMSEAKEANEKIWDVTKKFAKDFPKFISENNFKSFITKKDSEDFNNCEFTSNFEIGNLNFYRSPAYRKFFNYIDEEGGIFYWKWSDSIIHTIGLSMLLPKDKIHFFENIGFHYDKYNNCPLNDDIWNQYNCNCDQGNDFTFRSGSCGGHYFDIMKKDKPEGWDRLP
The following text describes a protein:
Function:
Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
Subcellular Localization:
Cell projection, bleb.
Sequence:
MNTYQTLRNISFLSHSLKMETRRPPLKRLCPDSGNESPRKKRFTTLEDESENCDPKFSEGSEFVSRASWSSLLRIAEKEIKPDTPAIPSIRSRIQMLTDISKDVKQDPEGFSDGLGEKSWTDNLQDSSLFSEPEKRRETEEIKGHPDVRSVLEKFEWKPDFENNLPLPLAESTIARRSHHQCEEDEPSSEGTVRRLRKERDEELAMVCSMLDRKNPWRAESMRHSQKQNVDQLNTDYAKERRKRRRVKTGRGNVKMGPIHDTETDSGASDSGELSLEGSEGVLDNSDDRYISSLEVKLQSTLNSDSCDGGIPLQQEGTMSPSCNPQEAKDPNQGRIYSDDSEEVRGQVTMDNSAFIDRLFEGVLDSSNESAYELSERELDLPPVSLLSPLTKSIALQAAISPLNSVVSSLPELLVEPPVTPVPNTRDDSPLLYSIDAYRTMRRNAQGELALQTITKMNYLSPEKTLKAQVDGDSKEKIKLLSKEVSALQRIVEQACRALSCCVDAEHGKGTRQEAEAERLLLVSNEKRKALLKEIDRLRGESAEEPLSCPSSGNLKPCRGSVTVTDIRLPLKVDYVCSNIRESGYPSHYFLILIRFGSHDIVATPLASAADAQTGDTIPFPTTVTLKDISSDFKIDIEVYSLAQGGAITIMDKRKTLKPKLTPKKLLGSRKSSLNSPGEWQCPDGAYSPAVGNIVRSSNFLLVGSLTLSLDSLGKFKFPLEKMKLEGKLGRILGNHFQDKVPFLSPLEGNLYIKLQCQSHSTVQRSGFLTMFEDVSGLGAWHRRWCVLSLNQLSFWTYPDQEALKEPLSRINLANCTSAKIEPAKREVCARPNTLELITMRPQREDDTDTLVTQCRNTLCFTKNWLTADTKEERNQWMEALNQVLVDLRTWKCGSARVSPQKPLQSPNS
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular Localization:
Cell membrane.
Sequence:
MLCSLLALLLGTFFGVRSQTIHQWPATLVQPVGSPLSLECTVEGTSNPNLYWYRQAAGRGLQLLFYSVGIGQISSEVPQNLSASRPQDRQFILSSKKLLLSDSGFYLCAWS
The following text describes a protein:
Function:
Protein-tyrosine-phosphatase that dephosphorylates and probably inhibits MPK6 in non-oxidative stress conditions. In association with MKP1, represses salicylic acid (SA) and camalexin biosynthesis, thus modulating defense response. May also repress MPK3. Dephosphorylates and inactivates MPK4 in vitro.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MATGKTSSAANLFTGSTRFDLSSADSPPSKLSLSSDQLNHCHQALGVFRGKIQNPDSIAHEFTGLQANRMWPSELLLNSTVAMNSVNVEKNRYSDVVPFDKNRIVLNPCKDSSAKGYVNASLIKTSESESISQFIATQGPLPHTMEDFWEMVIQQHCPIIVMLTRLVDNNRTVKCGDYFQDEDGPREFGNISLTTKWIKTTDTSLMLRNLEVNYKETEDQPMSVLHIQYPEWPDHGVPKDTVAVREILKRLYQVPPSLGPIIVHCSAGIGRTGTYCAIHNTIQRILAGDMSALDLAKTVALFRKQRIGMVQTMDQYFFCYNAIVDELEDLTAGTNAGTSS
The following text describes a protein:
Function:
Involved in vesicle-mediated protein transport between the Golgi and the vacuole.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Note=Associated with the Golgi and prevacuolar membrane.
Sequence:
MSNLLLIIDSVSQKIRDRRKLEEFGQNPDEEIESSLKDVRQELQKLNEEQSRLEKNAQIPEYRVRESEAFLIRMQRRLESAEEEFEKQRRASSIPADGTSAFSANPQVASTNNKLTPLPSLQKTTSSSEGSDIEMEAMYPVDGNDPDPINVNVLAQMHQQMLNEQEESLGGIEASVQRQKRMGYAMNTELSEQNVLLDNMNNDADRIERRFDHAKNRLNKVSRKAKQYPRCFIILLLCALLLLVASI
The following text describes a protein:
Function:
Pectin methylesterase (PME) inhibitor that inhibits PME in vitro. Functions as a critical structural modulator by regulating the degree of pectin methylesterification and the physiochemical properties of the cell wall components.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing PMEI28 are dwarf and have shortened culm length, due to increased level of pectin methylesterification.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MASSMAPAAAMAILLLALLMPATLCSRSGPPSSKHGHGGHAKRAPPPASPVVPVAPQAAALVRATCNSTAYYDVCVSALAADPSSTTADVRGLSAIAVSVAAANASGAAQAAAALANGTAPLAAAAAGDGTVQALLRACAGKYGDARDALAAAKESMGQQDYDLATVHVSAGAEYPQVCKALFRRQRPGAYPAELAAREEALNKLCSVALDIIALLTSSPASNNNNS
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
Sequence:
MTTYQKIIPIANQILKKYDLCDHCLGRLFTKQLYLSSNKLLGKKLKKNSKSSQRCYICKNLFDNLNYFLNMMIDSASHYSYSSFSVGATIKPSIIDRDDVIRSKYKLKGIDGIKTDVTKELGKLFSKKTKKSFDSLDPEIVFTVNLKDEFCDIRSKSLTLSGRYVKPVRGFLQKQKSCSNCSGKGCRICDFHGIKEFDSVEGEISQFLFKKLGGTTAKFTWIGGEDKSSLILGTGRPFFVKIQNPHKRKLRAKSANLEHIKVSNFKIVADSPKKPLKFNSSVEARISTSSIIDAKLLRKLKNLTKKPIAVYEKSGKRSEKRILSIKYKKSDETSFTLFFKFEGGLPVKRFVTGDDVSPGISQILDMSCKCLEFDFHDVEVK
The following text describes a protein:
Function:
Activation of RuBisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase; EC 4.1.1.39) involves the ATP-dependent carboxylation of the epsilon-amino group of lysine leading to a carbamate structure.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
SRLRQDGDQVRVGSTTALHAACVVIVVQLHACSLIMMSAGEPAKLIRQRYREAADMINKGKMCVLFINDLDAGRHDAVHGEQPDGERDADEHRGQPHQRAAPRDVQPPSPSSSPATTSPAHPRRAHGQVLLGSHPRGPHWRVQGHLPQRQGPRRVPIDFFGALRARVYGDEVRRWVAEIGVENIGRRLVNSAGSSWSSPR
The following text describes a protein:
Function:
Rescues ribosomes stalled at the 3' end of non-stop mRNAs. This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system. Binds the 30S subunit, contacting 16S rRNA with the N-terminus near the decoding center and its C-terminus in the mRNA entry channel; contacts change in the presence of release factor 2 (RF2, also named PrfB). Requires RF2/PrfB to hydrolyze stalled peptidyl-tRNA on the ribosome; recruits and probably helps position RF2/PrfB correctly in the ribosomal A site so RF2's GGQ motif can hydrolyze the peptidyl-tRNA bond. Does not release ribosomes with a programmed pause caused by regulatory chains such as SecM-mediated pausing. Binds tRNA which may stimulate its ribosome rescue activity.
Miscellaneous:
MISCELLANEOUS: Active protein is only produced when SsrA(tmRNA)-SmpB-mediated trans translation is limited. ArfA can be synthesized from truncated mRNA, via ribonuclease 3 and the SsrA tagging system. The arfA mRNA is cleaved by ribonuclease 3 within a hairpin structure, probably immediately after the Gly-55 codon, which produces a truncated non-stop transcript and leads to ribosome arrest. In the presence of SsrA, the stalled ribosome is rescued and the incomplete nascent ArfA is tagged for degradation. In the absence of SsrA, truncated ArfA chains are released from the ribosome and are functional. Truncated ArfA could be more active than full-length protein.
Sequence:
MSRYQHTKGQIKDNAIEALLHDPLFRQRVEKNKKGKGSYMRKGKHGNRGNWEASGKKVNHFFTTGLLLSGAC
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRKNDRGFPDRQAIVAFIKANQGNVGTREIAREFGLKNADRVELKRMLRELADDGTIKKKRHKVSEPDTLPSTLVADITGRDSDGELIASPTEWDEVESGEPPKILIVMPRRPKPGTAAGVGDRALLRVERIDETEGPAYRGHIIKVFDKAKSRILGVFRSLPEGGGRLVPVDKKSADRELNIAAADTQGAQDGDLVSVDIVRSRAFGLASGRVKEKLGSVKSEKAISLIAIYAHDIPLQFRPAAEREAEAAEPANLKGREDWRDVPLVTIDPPDAKDHDDAVHAQADDDPNNKGGFIVNVAIADVSFYVRPGTALDRDALDRGNSVYFPDRVVPMLPERISNNLCSLVPGEPRGALAVRMVIGPDGRKRSHTFHRILMRSAAKLNYAQAQAAIDGRPDDTTGPLLDPILRPLYTAYACVKRARDERDPLNLDLPERKILLKSDGTVDRVIVPERLDAHKLIEEFMILANVAAAEMLEKKSLPLIYRVHDEPTLEKVHALAEFLETLDVPFAKSGALRPALFNRVLAQLEGHDHFPLVSEVVLRAQAQAEYSAENYGHFGLNLRRYAHFTSPIRRYADLVVHRALVRALGLGEGALPDTETPETLGEVAAHISVTERRAMKAERETVDRLIAHHLADRIGSSFQGRVSGVTRAGLFVKLSETGADGLIPIRSLGTEYFNYDESRHALVGTRSGAMHQLGDVVDVRLIEAAPIAGALRFELLSSSGETAPQGRRASGRQRRPSFKAHPGRSPAKKHKPAKPKKPGKGKKNKGKGQKGKAW
The following text describes a protein:
Function:
DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation.
Sequence:
MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSAREVYLSAKVEAHQPEFPPSRRALDPRLHPPREAEVAVEVASPEAVQPPEPMDTQEEVLRVQETPALCDPPPARVSRKRRSSSDLSDGSDAGLVPSKKARLEEVEGEATSEVPDRLQLPPAQSEGAFPNLARVLQRRFSSLLNCGPAVPPPTPPTCEAKPACRPADNMLNVLVRAVVAF
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MASDLVAYVNKLLPGATPLDLSADIKKKDWAPVVAAVSPKLPQLLTLTAETDVEGAFALLWDVVLALPEPQAQALQLLQVVKGEAQTSPVLRLRVAASLFNKAKGQPQVQLQALLDVISLAASSGNVELVAPYLSQVETLLDTQKLSVDERRVLLLAVADVLEQSGNKLKVLVVLDKFLATFEQGQVAKDQAARAAQIVLQNPVASFLARVDLAASAVVQASLQGSKLLELLDIVSTKTLKEFTAFQKSAGGVFTENGLQEAEVADTMRLFTLCTLPTGFQDIPYADVAAALDVDEEDVEKWVVRAITAGLVNAKIDQLARTVTISRSLQRRFGAEQWKEMDAKLQLYKKNVGGLLDIIRNARRAQEQQ
The following text describes a protein:
Function:
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
Subcellular Localization:
Nucleus.
Sequence:
MAVAVETRPELVGKRFLCVGGGEEPAESGRWRAGVIRAVSQRDSHSPDLAVYVEFDDLEWEKREWVKVYEDFATFLVEYQLVWAKRKDPSQTQGSKIKQIQWPALTFKPLVGKSVYDSITAVEFLVDKQLDFVTEDSAFQPYQDDVDSLNPVLRDNPQLHEEVKAWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMVVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRSNQNSNTVHGHYTRAQANSPRPAMNSQTAPKQNSHQHQQQRNTRPNKRKGSDSSMPDEEKVKEERFDYIGRGENPKNKNKHFLSKRRKPEEDEKKLNMKRLRTDNISDYSESSDSEISNKRLTDSSSEQNSENELKSKNTSKINGEEGKSQTVERVEQTLTDRRSPWDEVQEDKKREEPERLKSSLLDQQEKPSLHAAEQPTPYEQNSKDPHVQECNAEKHHAAELKNEQFVPKPPTPKSVVDKTSKNNSEKESQDNAASTFGLQTVQKIESHSSDLKQQFANANFLEARKQEADQSWVSCVVNKMDLMQPGVVKANEHLNPEKEKVPYGSFMSSLNVASVAEDSKLRKQSPVPDSVKSKPSASVDHPKTKSPDVKPKFTPSSDTVKSKVSSQNSHAPGLTRSANKTDHDLPRSSFHPVPARVSALEATKSPLIIDKNEHFTVYRDPTLIGQETGTNHISPFLHQHNYPLHSSSHRTCLNPNAHHPALTGSSHLLPGSSTQTPLSAINTHPLSTAPHHSVHHPHLLPAVLPGVPAASLLGGHPRLETAHASSLSHLALAHQQQQQMLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPETPVNTEASLRRNTPSPWLHQPTPVTSADSLGLLSHIPVRPSSAEPLRPLKLATHSSPPLSKSIVEHHKEELERKAFIEPLRSATTAPIKTELEQSRTQAAKESHMHRHFADPMLNQLPRPPQETGERLSKYKEEHRRILQESIEVAPFTAKMKALEGERENYSRVTSLSSSPKSHSVKYDKDAERSVSELYKMKHSVPQSLPQSNYFTTLSNSVVNEPPRSYPSKEASSAYVDKQTNCPSTAASPQSLPSYISSLSKPPPLIKHQPESEGSVSKVPEQLSQSVQSHSVGSFRNDSRSPTQLSVSSSNTLRSMPALHRAPVFHPPVHQNLEKKESSYSSLSPPTLTPVQPVNAGGGKIQELQKPPTLVPEPKEAQTVYKGSSDQNLSEAWKSNNTAANEKVDWHGERASGKAQSATASVIVRPPSSTKYECVAAVQSTSKDRVSERSSAVTNQADCLKTAEARETGRVILPNMNSDSARTQYEKKFPAVSQGTVARSVTPTTAMICSTKMDVTTSAATTTSVLSWGSSEVTYSLSSTALACAPLESAGSRAAGQAAAPAQEHKGSTPAPAAPAPGKAGSAAQPGPGFSTSADFVHLKKHKAALAAAQFRSSNPSETESNSVKNQTFSTSLSLDSAIVCNTINKANSVGSGQTSQASQPNYHTKLKKAWLTRHSEEDKNTNKKENSGNSVSEIIKPCTVNLIASTSNDLQNNIDSKILADKFVKEDKHPRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQRKKGDAEEEVKPNGVLSRSAKEKSKLKLQSGSNSTGIPRSVLKDWRKVKKLKQTGESFLQDDSCSEIGPNLQKCRECRLIRSKKGEEPTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEALSLWTHENYEDDELDLETCKYILDIIGDKFCQLVTSEKTAMSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHSIRDKFEIKSHCQCTSKQSMQAGKLPAMNGVSQVLQNVLNHSNKISLCMPESQQQNTPPKSETNGNTSPRSDVSTDSKLTPPESQSPLHWLADLAEQKAREEKKENKECPSGKHSKEEKDQDNLESQNCKSSPTASQNNEQGSTLRDLLTTTAGKLRLGSTDAGIAFAPVYSTGTASGKSGRTMPNILDDIIASVVENKIPPNRAPKINVKSEVKDEPKDDRKCIQDDGNKLYSDIQYSWICDKHVLWLRDHKNNNNWKLFKECWKQGRPVLVSGMHKKMNFSLWKAESISLDFGNQQADILNCKDSIISNTNVKEFWDGFEDVSKRQKVKNGETALLKLKDWPSGEDFKAMMPARYEDLLKSLPLPEYCSPEGKLNLASHLPGFFVRPDLGPRLCSAYGVAATKDHDIGTTNLHIEVSDVVNILVYVGIAKGNGVLSKSGVLKKFEEEDLDDLLRKRLKDSSELPGALWHIYAGKDADKIREFLQKIAKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVKTCTVIQFLGDAIILPAGALHQVQNFHSCVQVTEDFVSPEHLVQSFHLTQELRLSKEEINYDDKLQVGNDSCSGR
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MVPFWRAIVPFWRAAGMTYISYSNICANLVRNCLKEPFKSEALTHEKVHFSISK
The following text describes a protein:
Function:
Regulatory light chain for the class II conventional myosin MYO1. May play a role in the disassembly of the MYO1 ring at the bud neck at the end of its contraction during cytokinesis.
Miscellaneous:
MISCELLANEOUS: Present with 1127 molecules/cell in log phase SD medium; MISCELLANEOUS: This chain binds calcium.
Subcellular Localization:
Bud neck. Note=Forms a ring at the bud neck in a MYO1-dependent manner.
Sequence:
MDHSESLTFNQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTSTAEVGEEGVSFPIFLSIMGKNLSQFPEREELEESLKAIGRGHDLNVPLNEVIDSLKEAGFENPEEEFAKLFKLFTTNQQATEERTFRGKLFLDSITD
The following text describes a protein:
Function:
Catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. Also exhibits ethanolamine kinase activity but it is a poor substrate at 14% efficiency compared with choline.
Miscellaneous:
MISCELLANEOUS: Present with 3930 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MVQESRPGSVRSYSVGYQARSRSSSQRRHSLTRQRSSQRLIRTISIESDVSNITDDDDLRAVNEGVAGVQLDVSETANKGPRRASATDVTDSLGSTSSEYIEIPFVKETLDASLPSDYLKQDILNLIQSLKISKWYNNKKIQPVAQDMNLVKISGAMTNAIFKVEYPKLPSLLLRIYGPNIDNIIDREYELQILARLSLKNIGPSLYGCFVNGRFEQFLENSKTLTKDDIRNWKNSQRIARRMKELHVGVPLLSSERKNGSACWQKINQWLRTIEKVDQWVGDPKNIENSLLCENWSKFMDIVDRYHKWLISQEQGIEQVNKNLIFCHNDAQYGNLLFTAPVMNTPSLYTAPSSTSLTSQSSSLFPSSSNVIVDDIINPPKQEQSQDSKLVVIDFEYAGANPAAYDLANHLSEWMYDYNNAKAPHQCHADRYPDKEQVLNFLYSYVSHLRGGAKEPIDEEVQRLYKSIIQWRPTVQLFWSLWAILQSGKLEKKEASTAITREEIGPNGKKYIIKTEPESPEEDFVENDDEPEAGVSIDTFDYMAYGRDKIAVFWGDLIGLGIITEEECKNFSSFKFLDTSYL
The following text describes a protein:
Function:
Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
Subcellular Localization:
Nucleus.
Sequence:
MGVLNVTSSGAAIVEYHQQQQQQQQQQQQQQQQNKKNDTIFSPIKNKMKVLKKIKKRMGLATRSASSCPGPNNLPPLQFHTVHGDNIRISREGTVAKRYESFCKGITFSARPVRVNERVCVKFLDISNNWSGVIRFGFTCNDPASLRGNLPKYACPDLTNKPGFWAKALNERYCYRGNVLFYYVTPSGDVHFGINGEEKGVFITDVDARGPLWAVIDVYGNSTAIEFLDSRIYMFQAQQQQHQQQHQHQPQHHGGPPHAQSQTARRPTEPELGLPQLESLSINQHNHQLMEERPVTCGALSPSTSVRYHSPAPGLLPLPFHPVRGRNIKFSADRYVATRADTEFCQGYVFSPRPVKIGERLIIQILKTDSIFVGSLALGLTSCDPASLQLNDLPDDSDMLLDRPEYWVVSKDVASTLVRGDELCFSVTVNGEVQISKNGGAPSVIMHIDQSLQLWAFLDVYGSTQSVRLFTLPMPAPPAPSACASSMYSMARSHSSLAAAAATSQSVRSLHQQEQQVMAESSANSCRTLAGATSTSALVQQATAATAATAAVRSDMIQINPGGTVLVVNLPPADVLSQQQQQQQSPQVPQATLVTRGMTNSASTLSVPLSTLSLSSHTGSTGTASELMVSNNSSNNYAASNNPPPYPESLSSYNNAANYSTAALAANGIYSSTNCVDCTICFEKPIDSVLYMCGHMCMCYDCAIKQWRGIGGGHCPLCRAVIRDVIRTYKS
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MPSLPSASRFTTSTTNGTANDSSSVGRPSADNEDSAIRNASQGSLATTPPPTPDTTPRVTSPTSIAAENRSRAQLAAELSKVELLRAAARGPGKPNARGITGQTSTAAAPTKAPGGSTPSDAGSIAARKDQRDLQQTVGQARQPPADDHFGRLIPGVTYPASVAWDEQRPYLTGDFLEASSSGSRTAQEGKRSVLGTGKSGVGKYSSAVQELLLIDDLLYAMGGADGEYVQARPKAGKLGEVVFNLDESMDLSLRELAKRILPLCESYHLIAHFVEVRWHYKHGLVSHALAAALRGLLQDYLIMVAQLEHQFRLGKLSMQGLLFYSQPMMDALGMLASVVKTALEDRLYGAGLLNLLQNKASALAGDKAARALLQKLVQDARAPYFRILERWVYGGEIDDPYEEFLIQEKKDFKKEGLRDDYRAGFWREHYVLRSEIPAFLAATAETIRTTGKYLNAIRECGEQIKGPDAGEDTRLHALADRVFLERINLAHMRASQQLLDVLLQKENLMGRLRSMKHYFLLDQGDFLVHFMDIARDELRLRPAQISVEKLQSLLELALRTSVCSADPFHEDLTCDVERQQLISQLHSSLRSGPDGRPVLDFTSLAEPGPSEGAPINISGLDTFTLDYKVRWPLTLVISRRALTKYQFIFRHLFHCKHVERQLCQTWQVHQTMRGLMGFTLMQPSYFLCQRMLHFIQTYQHYMTFEVLEPKWATFESKVATAKTVDEVIALHDEFQDSSLKECMLFWPQILKRVEKVKRACIFYCMVTQNLVPAVSLPDDDDEAERGSASGPPSRRPSVNSASSGGAYADFREQHKLRRELAIQHALQAAEDSGIEAKIQEAETAFNRDMMDLVVVLNSASQDEPYCAHLAQRLQGVGQGIAEFGMI
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MNNQNVNDNNLLLISRMYPNVYASSVPQQVDSKPVRPRRRRKSKNVEMAQEGGDGSNGWFRKRKLSDEQVRMLEMSFGLEHKLESERKNRLASELGLDSRQVAVWFQNRRARWKNKRLEDEYTKLKNEHENVVVQKCHLDSEVLHLKEQLYDAEIEIQRLAQRVEGALSNSPISTSISVEANLTTPFFGDYQIGDDGEGYENLFYSPEYIDGLEWMSQLM
The following text describes a protein:
Function:
Does not have a catalytic activity.
Subcellular Localization:
Secreted.
Sequence:
MGRVGGLSPPRVLLLLGATLGATAHIRPMLAPEDWWTYKDSLQGNFVPGPPFWGLVNAAWSLCAVGKWQSPVAVDTGRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGAQDGAGSEHQLNHRGFSAEVQLIHFNQELYGNLSAASRGPNGLAILALFVNVAGNSNPFLNRLLNRDTITRISYKHDAYFLQDLNLELLFPDSFGFITYQGSLTAPPCYETVTWILIDQPLNITSLQMHSLRLLSQNPPSQIFQSLSGNTRPLQPLAHRALRGNTDFQHPERRCRGPKYRLHVEGSSPPATS
The following text describes a protein:
Function:
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of asperfuranone, a probable antitumor agent. The polyketide synthase afoG is responsible for producing the 3,5-dimethyloctadienone moiety from acetyl-CoA, three malonyl-CoA, and two S-adenosyl methionines (SAM). The 3,5-dimethyloctadienone moiety is then loaded onto the SAT domain of afoE and extended with four malonyl-CoA and one SAM, which leads to the formation of 2,4-dihydroxy-6-(5,7-dimethyl-2-oxo-trans-3-trans-5-nonadienyl)-3-methylbenzaldehyde (compound 2) after reductive release and aldol condensation. AfoD is the next enzyme in the biosynthesis sequence and hydroxylates the side chain at the benzylic position of compound 2. After benzylic hydroxylation, a furan ring is formed after five-member ring hemiacetal formation and water elimination. AfoF and afoC are proposed to oxidize the R-diketone proton and to reduce the unconjugated carbonyl group, respectively, to generate asperfuranone. Since no intermediates could be isolated from afoF and afoC deletants, the sequence of these two enzymes is not fully understood. Moreover, since afoC deletant still produces a small amount of asperfuranone, other endogenous oxidoreductases might catalyze the same reaction with much less efficiency.
Sequence:
MRFLLQSITLVAAARAASIDLESLFGPYVSPETEIAEVGDADFDEVVSPRWSEWRPPTWTGAIKPQTEEDLQEIVRIAVANNVSFMATSGGHGTSLIYGTVKGLDINLANFNNVDIDLESNTVTVGAGAKLGDITEPLYKAGKAIQTARGNSPCVGVIGATIGGGIGYETGLFGLGVDALVSVRIITATGELITANETCNSDLLWAIRGAGANFGIITAATFKMFDQPNNGDAVIGTFVYNSSKSLGVFEYLSVLDNVLPPELGVQLSIGYDRTINETLLTVDIKHFAPWATFVDHWEHAEALGPISRNVSNVTLVELYAGLDGPCQTGAYVSGGTVGLGRTDAATMQEVFDDMTAFYEQYPGYLGQSLFQRYANNNTLKTPAHTAVYPWRDTKMFWLHENIFLNPELEAPTNELLVSLREKLHATSGFPADQPHIYVNYAFGDEGPEAWWSKENLPKLSYLKRKWDPKGVFGKGTPIPRF
The following text describes a protein:
Function:
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Has an essential role in mediating growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae.
Sequence:
MAERDRVLERERRQMEQILELDMEELQVEEVDDDGSSSSSDVDTFLRNTHGDGGINTYEELSIDTSTVSLQDHTYLGAKVDGARGKFAFLHGDRVLNLPMFYLQGVVLFPEASLHLRVFQPRLVEAIDKAINHVDAPCMIGVVYVYRHTNDGHYTIASVGTMAEILKIQQLYDGSSCIFSHGQQRFRLLRHWLDVDGVPWGEVQIIEEDTPQRTPRDAFAQLAAPNSFRDSLSPTSTSSDHSITDKRIYLLGSRSSGLVRCGIADESSNEGQNSVHEQSCQSHDSVKEIDGYGQPDKNTNTGDEDNLCFISSKSFQRTRKKDTKQQKHYFTTKNASQAPLSFWPHWAYEMYDSYSLSRRAAEALSQIDGVSYRLQREIQLLKAFNIIRCRNCLIRIARRSDMVVTSSDSPMSLHSRPHGFVKEIITVYNATGLALRGDPSKTHSWFPEYTWTIALCNACQSNIGWLFRVDDKNLHPRSFWAIRSSQISDDTQSRDRTDQTIHV