lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSRRRHSDDSDDSDGQPHKRRRTSEPSEIEERLESLICRVGEKSNSSLESNLEGLAGVLEADLPNYKSKILRILCTVARLLPEKLTVYTTLVGLLNARNYNFGGEFVEAMIRQLKECLKVNMYNEAVHLVRFLSDLVNCHVIAAPSMVAMFENFVSVTQEEDVPQVRCDWYIFAFLSSLPWVGKELYEKKDAEMDRLLSQTESYLKRRQKIHVPMLQVWTADKPHPQEEYLDCLWSQIQKLKKDRWQERHILRPYLAFDSILCEALQHNLPPFTPPPHTEDSVYPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHCIIKSHWKERKTCAAQLLSYPGNNKIPLNYHIVEVIFAELFQLPSPPHIEVMYTTLLIELCKLQPGSLPQVLAQATEMLYMRLDTMNTTCVDRFINWFSHHLSNFQFRWSWEDWSDCLTQDLEKPKPKFVREVLEKCMRLSYHQRIIDIVPASFSVLSPANPVCIYKYGDESNRSLPGYTVALCLTIAIKNKASNDEIFSILKDVPNPNQDDDDDEGFTFNPLKIEVFVQTLLHLAAKSFSHSFSALAKFHEVFKTLAESDEGKLHVLRVVYEVWKNHPQMIAVLVDKMIRTQIVDCAAVANWIFSSELAHDFTRFYIWEILHSTIRKMNKHVLKIHKELEDTKARLARQHKRRDSDDDDRSSDREDGPLEEQIERLQEKVESAQSEQKNLFLVIFQRFIMLLTEHLVRCETGGIDVFTPWYKSCIERLQQIFLQHHQIIQQYMVTFENLLFTAELDHHILAVFQQFCALQA
The following text describes a protein:
Function:
Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in roots and hypocotyl. Together with GL3 or BHLH2, promotes the formation of non-hair developing cells (atrichoblasts) et the N position in root epidermis. Regulates stomata spatial distribution in hypocotyls. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes such as GL2 and of CPC.
Miscellaneous:
MISCELLANEOUS: This protein is called 'Werewolf' because plants lacking WER exhibit hairy roots.
Subcellular Localization:
Nucleus.
Sequence:
MRKKVSSSGDEGNNEYKKGLWTVEEDKILMDYVKAHGKGHWNRIAKKTGLKRCGKSCRLRWMNYLSPNVKRGNFTEQEEDLIIRLHKLLGNRWSLIAKRVPGRTDNQVKNYWNTHLSKKLGIKDQKTKQSNGDIVYQINLPNPTETSEETKISNIVDNNNILGDEIQEDHQGSNYLSSLWVHEDEFELSTLTNMMDFIDGHCF
The following text describes a protein:
Function:
Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function. May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MRGQRSLLLGPARLCLRLLLLLGYRRRCPPLLRGLVQRWRYGKVCLRSLLYNSFGGSDTAVDAAFEPVYWLVDNVIRWFGVVFVVLVIVLTGSIVAIAYLCVLPLILRTYSVPRLCWHFFYSHWNLILIVFHYYQAITTPPGYPPQGRNDIATVSICKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFREAYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGALTVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDNWKVFLGVDTGRHWLTRVLLPSSHLPHGNGMSWEPPPWVTAHSASVMAV
The following text describes a protein:
Function:
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Subcellular Localization:
Secreted.
Sequence:
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGTVHDDATMPSYYYYVDPAGPAYEPQQPNPIDDLISVYGLQDISRQVARTNADGTKAVKLRKSYKNQIQDLSGKFSVIPTRENGKGGEISPIVFQNTDGDAVRERGMGPEEWRRAQVFRDQALFEAPTMDWDMCAEVISQFERSYPGEFKNQGFEVEDLAFDLDGSGANGAALGGKAKKRKSRSNGSSMATPNSDLQEDIKRRRLE
The following text describes a protein:
Function:
Unknown. Component of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis.
Sequence:
MNETTTKQPLKKRSLSSYLSNVSTRREELEKISKQETSEEEDTAGKHEQRETLSEEVSDKFPENVASFRSQTTSVHQATQNNLNAKESEDLAHKNDASSHEGEVNGDSRPDDVPETNEKISQAIRAKISSSSSSPNVRNVDIQNHQPFSRDQLRAMLKEPKRKTVDDFIEEEGLGAVEEEDLSDEVLEKNTTEPENVEKDIEYSDSDKDTDDVGSDDPTAPNSPIKLGRRKLVRGDQLDATTSSMFNNESDSELSDIDDSKNIALSSSLFRGGSSPVKETNNNLSNMNSSPAQNPKRGSVSRSNDSNKSSHIAVSKRPKQKKGIYRDSGGRTRLQIACDKGKYDVVKKMIEEGGYDINDQDNAGNTALHEAALQGHIEIVELLIENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGADPTIRNAKGLTAFESVDDESEFDDEEDQKILREIKKRLSIAAKKWTNRAGIHNDKSKNGNNAHTIDQPPFDNTTKAKNEKAADSPSMASNIDEKAPEEEFYWTDVTSRAGKEKLFKASKEGHLPYVGTYVENGGKIDLRSFFESVKCGHEDITSIFLAFGFPVNQTSRDNKTSALMVAVGRGHLGTVKLLLEAGADPTKRDKKGRTALYYAKNSIMGITNSEEIQLIENAINNYLKKHSEDNNDDDDDDDNNNETYKHEKKREKTQSPILASRRSATPRIEDEEDDTRMLNLADDDFNNDRDVKESTTSDSRKRLDDNENVGTQYSLDWKKRKTNALQDEEKLKSISPLSMEPHSPKKAKSVEISKIHEETAAEREARLKEEEEYRKKRLEKKRKKEQELLQKLAEDEKKRIEEQEKQKVLEMERLEKATLEKARKMEREKEMEEISYRRAVRDLYPLGLKIINFNDKLDYKRFLPLYYFVDEKNDKFVLDLQVMILLKDIDLLSKDNQPTSEKIPVDPSHLTPLWNMLKFIFLYGGSYDDKKNNMENKRYVVNFDGVDLDTKIGYELLEYKKFVSLPMAWIKWDNVVIENHAKRKEIEGNMIQISINEFARWRNDKLNKAQQPTRKQRSLKIPRELPVKFQHRMSISSVLQQTSKEPFW
The following text describes a protein:
Function:
Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel (By similarity).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MGTWILFACLVGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRIALVLTPLKWYQSMIRPPYSSYGYEPMGGWLHHQIIPVVSQQHPLTHTLQSHHHIPVVPAQQPRVPQQAMMPVPGQQSMTPTQHHQPNLPLPAQQPFQPQPVQPLPHQPMQPQPPVQPMQPLLPQPPLPPMFPMRPLPPILPDLHLEAWPATDKTKRE
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MAVHAMFNNAAPPLHVQSLEKAVEVKPLIHYIDALVKDPKRDLYRTDDDRYNEEKVSNGIIDRKSDKRFWKGIIKNKDKKKTSYNFANVNKSRRWLQDMLLSESSESSTDDCTMTHDDLIVLLKLHKRKRKYQNVFSRKKELKQYKYYSSGLLLEEDKYVEPKSKKNAEIEHVKAEKGKRGRKKKATKEVTPKKSSEKDTVNEDGSVSVEKVVKKVKSRRQEIEIIRRKIWIAISRKEAIKAQRARSNIQHNTLINLKKVSQLCQKEIRRKAIKSQRTSKDILPRSKRLVKEMLLYWRKYEKVEREHRKRAEKEAQEQRRLDEEIREAKRQQRKLNFLITQTELYAHFFSKKLGVAEKNDATEEQILSKLEDGDQSREITTNSGIIVDTNVDDYDDDLMKEQVIKNVQDALNLQQAKTHKYDLDKHASSAFGEFSLANPSISTETSFPQPMMFQGQLKTYQLKGINGILADEMGLGKTVQSIALLSYLSETQNIWGPFMVIAPASTLHNWQQEFMKFTPKFKVLPYWGNQSDRKALRKFWSQKEFTADDSPFHALITSYQLIVQDMRYFQKINWQYMVLDEAQALKSSSSARWKILLSFNCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDCHQEFNEWFSKDIESHAENKSAIDENQLSRLHMILKPFMLRRIKKDVENEMAEKPFSNLFLFVKRSVCNHPELFERRDVRSPMWMKAIKYQLPKLIHNEGMNLATYKIKKSRYFMTDLNLTNPFHVYNSLFKVSTLDYSNGYSFTRFINLSPAEFSAITSSLNQTRLSMMNTTMEHAIQIYFRHMLRVNYPECREELYSYTKNYFLILWPTFRCSFPSSRFSSCLRNLIFTSYTNAVISHQDHHIYSKASAIHNNILASVCSSSITQVSSLDGGNEENVEEIDVETSQKLNNTSSPSHQVTNSKSTILKTMPTTCPSFLVCYIPKAIAPNVSTYCVDRGAANKDIETSSMKSLSSWYPARKGTKLREGLHTSLRNVIDWEVVRPLNGWSYMAIPDKKSLVTDSGKLRILDVLLKKLKFEGHRVLIYSQMTRMIDLLEEYMGFRKHIYMRLDGSSKISDRRDMVADFQSKSDIFAFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLVTSGTIENRILKRAQEKSEIQKMVISGGNFKPDALKSREVVSLLLDDDDLEKKFKQKEEERKALGGQSKERKKKRENGTDKPPAKRGRKKKQPVIVDVETIDKPIEFVTNSANGSLSGLEGMSIDGEIEQADDIDNANISVTEVGSETSSIPDNQLQMSPIDVEKSRGRGRGRGRGRGVGLEAQLEVQEVQEVVGPLEGVEEDVAEEEAVQLLRQLRPLLVLQQEQPPHLPLTVTI
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADEEGEKRKAKRHTKKKNAKRSSTDEHTDGEESRRKTLEASIKAQVAAEQRAHQIVEKLVLEEFATPEYFLEIGNYITHRHYSDVVTERFIIKICGYPLCPKSLTNIPKQTFKISTRTNRVYDITERKCFCSNICYKASKFYESQLDESPIWTRSRAGLKEFTLLCGNKTSISPGNVILGSGSLAAETMNSPKGEVTTNIGYGKEATDGDCVSDDHMIGVKHDNDDATAQVSNAFDKLSLSSEVGPRTMSKIEIKEKSVGQDQQYIEKMSTEETRKTRSVNYNENSVTSVDPSCVRSMNSFDNKSTSVTSHSDLFSTCVTTHDAGISRDDLLSTSVTWGGAMHTESTTSQAFLDSVKEIFLQWWTERSISFMATSSRTCEEKEEKGSTFEEKALHFITHAENSDSEKDEDTTLPKKENSTTSEVRPCVLPPIDSKSQQVIRKRIVLQTLNRVLPEFLHSLGVTVSDISSDLAQLVKTFRLLSQNTMLKTLQWNVVAVVLILMLRHRNKIIKERLETTPDPKSALLKGLGLANEEFDPFFLALEKKLLDKGHSLTDHQSTSDIPRTQTHKVEQELGTALHERREHGNVGTFVEFRIENSARTQKTEEKPVTRHKKGEDDWPMGINHGSACVEKYSEMEDLD
The following text describes a protein:
Function:
Required for growth on non-fermentable carbon sources.
Miscellaneous:
MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSIASQKKVKPSFVCLRCKQRKIKCDKLWPTCSKCKASSSICSYEVEPGRINKSPTIENAPHRDIRNITPASMSASGSFTSILNPSTKDWEMKNFAMNLSNAHDKLVVMNNTTIVDSPFAFHSILQHDLYAKALTTCIHERILIDVERHRENVSANNKKRELNLTIGDIGPLFFIDKAALKFIENTSKTSKLYPPIDFLYNTYDYEQAHPEENNDKISINILLEELSKYFLNKNEVDGLIVDFYKTIYPVYPLLEISLFEDNIRELLQLNEFNGYNIVFAGKDSRRKLETITLLTIILAFSYRRLSLSTSHSFKESFGVKSNNLTLLAHKLLALMNVFQYVNEHTLCCLLYFFILRYLNPDQADMYPTHSDILNLKFLENVAIKLGLNEEPFQYTRYVSESDDYPRLFNLRRKLWLGVQFLKFGILIPEGDSDILSLEYLRSFMKTDESLPELFERNYASTNNLDLSLMATAENIYHLHLSLQVLLTSCFPINGPSYLKEVLDNIDKTKDFLNQKFPLILSSLGEPRMKSLHINVPSSLANEESFDFSTFEENETFIANVISYTCTMNIYDSLSLHFENQCFKNALEYKTYYHRFTFTAIQDYLTLLKLISEYFNGSLLHLREPFGFATQKVVRFSIHRLLIFQATLLVRLFYKKDTCDRSSAAMGMLNDRNGRLSRVIEKMIKLMSYHMKLLVEIVISKLEKSYLGSFISVSIFRYIIYLVDTDALSAFISDYWKSDAVMDERYSRIHRIVGLKWGMGRDKSFSFTSKLNNPQFLGSLDLEILEELEKLISAQEFSRNFTEDVDESLQSEIDLMNYDNEALNQLMAIDLDKLLGIFPNLSNF
The following text describes a protein:
Function:
Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
Subcellular Localization:
Cytoplasm.
Sequence:
MLVVKVGGRALRNLREICRDLAKYEFILVHGGGDEVSDVSRRMGIEPKFVTSPSGLRSRYTDENEIEVYVMVMAGKINKLIVNELLNLGIRAVGISGLDGPTLIAERKERIIVQEGGRRFAIPGGYTGRIVEVRRDLIDSLTRSGYSVVISPISRGKGGEILNVDGDQAAVSIAEAMLPEGLVILSDVDGVIVDGEVRRVIWADEIGSIEGIGGGMLRKLMMSAKVAGLTRVLIANGLRDEPVTRALRGEGTSIEVR
The following text describes a protein:
Function:
Catalyzes the hydrolysis of alpha,alpha-trehalose into two molecules of D-glucose.
Sequence:
MVLHAQPPDQSTETAREAKALAGATDGATATSADLHAPMALSSSSPLRNPFPPIADYAFLSDWETTCLISPAGSVEWLCVPRPDSPSVFGAILDRSAGHFRLGPYGVSVPSARRYLPGSLIMETTWQTHTGWLIVRDALVMGKWHDIERRSRTHRRTPMDWDAEHILLRTVRCVSGTVELMMSCEPAFDYHRLGATWEYSAEAYGEAIARANTEPDAHPTLRLTTNLRIGLEGREARARTRMKEGDDVFVALSWTKHPPPQTYDEAADKMWQTTECWRQWINIGNFPDHPWRAYLQRSALTLKGLTYSPTGALLAASTTSLPETPRGERNWDYRYAWIRDSTFALWGLYTLGLDREADDFFAFIADVSGANNNERHPLQVMYGVGGERSLVEAELHHLSGYDHARPVRIGNGAYNQRQHDIWGSILDSFYLHAKSREQVPENLWPVLKRQVEEAIKHWREPDRGIWEVRGEPQHFTSSKVMCWVALDRGAKLAERQGEKSYAQQWRAIADEIKADILEHGVDSRGVFTQRYGDEALDASLLLVVLTRFLPPDDPRVRNTVLAIADELTEDGLVLRYRVHETDDGLSGEEGTFTICSFWLVSALVEIGEVGRAKRLCERLLSFASPLLLYAEEIEPRSGRHLGNFPQAFTHLALINAVVHVIRAEEEADSSGMFQPANAPM
The following text describes a protein:
Function:
Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
MIATLSRNARADLRSSHLTLEHFLMRSRTLSLYRKYVRATRDIPHPEARWETIQFFRDDVHRFRHETDLEQIKGLLMQGHRFLKQMQGQWTLAGASSDGSANKLRGTRQL
The following text describes a protein:
Function:
Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity.
Miscellaneous:
MISCELLANEOUS: Present with 623 molecules/cell in log phase SD medium.
Sequence:
MSVPNSKEQSLLDDASTLLLFSKGKKRAEEASKIGSKTDTIEHDESHEREKKGAIEMAAAALATASTVSLPLKKATEQSAAEAATSTAAKEETENQPQKQPQWPVPDSYIVDPDAGIITCICDLNDDDGFTIQCDHCNRWQHAICYGIKDIGMAPDDYLCNSCDPREVDINLARKIQQERINVKTVEPSSSNNSASNKNNGRDRASSTTISDVGDSFSTDQDNTNHRDKRRKRNPSNNSIDSKNESASVNSSDGLTSMPKKKEHFLSAKDAYGAIYLPLKDNVFKSDLIEPFLNKHMDDNWVIQYPHKTFKSVSIEVKPYADIAYSRTYPGFTKLGVYLKKDCIKGDFIQEILGELDFYKNYLTDPRNHYRIWGTAKRRVIFHSHWPIYIDARLSGNSTRYLRRSCQPNVELVTIKLQDTDNRNDKSSGRKSSRIKFVLRALRDISEDEELYIKWQWDSKHPILKLIKGMTIDSLDDLERYGLINSVETILSNGECGCGNNSKDCYLLKVKRYAQSLYKSVKSRGKMNNRYKLNEILNQYNCKKRREPPILHRLEEKAQNTIERAPILLNNFYRQKFLNRNNGPKIPQKNTIDSTNNPDDIAKPFKFALFAQHSSNISVPKKNETSEKPLIITKSTDYDESHITNIEELPIPVLLPINKTSRQTANDVEESQSKNEHKLSRTPSLSNFNKELSKEAQHSQAKTKEIMTEASVNSRRESTPESIMHLSDFSSSQLHSKKKLSFADYRKKLLK
The following text describes a protein:
Function:
Probable transcriptional regulatory protein Required for G1/S progression.
Subcellular Localization:
Nucleus.
Sequence:
MNISSQNVLLPSPIPSSSPMASHKKSWLSKHPNQSMTFEKPQLGQFVLTPEPSSNTFYAPSSPASAVRREPLSPMSFVRMRSHRVNKIGRSSQQCDHVLSTVDKAISRVHAIVTCTQDRMIIECVGWNGMIVSDKMRKSVFHMKKNDRIVLVRPNSDACPVLDVFGYRVLLGWPSDSEDEWEGNLNAKNYEENREPMSPSPQEALPLMPSSPPSQDYQNDQNHLILYTNSESIPKLNLRSNELVYPPPSKDLLQKLLALEKDGQVEKSDCSKNTQLKPSFLPKNTDDLLNGTDDNNIVLREVKVSFENEKIESDDLDKNEEISEGEEYTPIEESKEPITVRRDSVIQIDESSAGLTDVISELNFTNHNDDSKNSNITTSNDSPVNEVEPMAPELSSAVVEKKEPEDYESISAVDENTNDSNESLPSSHDYSESTKENSAPDSLLLGLVLDELVFSTTSTTPLPALSHLFPSNMPLQLIQDKLRDLAAKHPYFEEVKRYGTDANGDPLWSEWFYNPDVDDDLERRMRYAPLMRPVRSSRRVHKQYYWKKPRARPRSSGHSSRRRRLS
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Sequence:
MADPPNSEFSTTDMEEDEDSDLEEGLQELPLRRRESARSYNSSGSDWSLSTVRSNFGEWLLREESDDRGGGLRGLLDQDRPSLIDGLLCELYDRVPYGLGRDSLDSDTYTEYSSTSEVHCAGTRSEQELEPSHLTYTSRVQSACLREKEVKELRQMVEELSRRTNMISQKLVRQLKRRDRRKSKLQKNCDILTAILQAVSEKRRIDTRMKFSIEPMPGKKGFRQWFDAMKAVVRLPHGLPSEWRKRVWLCLADKHIQNLQLDWDKMCRLAFNERSNPDDDKLGVQIVKDLHRTGCSGFCAEQDRVVLKRVLLAYARWNKSVGYCQGFNVLAALILEVVERVEEDALKVMIYLIDYVLPDSFFANNLRALSVDMAVFRELLRIRLPDLSKHLDDLQKRANSNPQGNYEPPLTNVFVMQWFLTLFATCLPKSTVLRVWDSVFFEGSEILLRTALAIWAKLGDRLRDLDSADQFYGTMAMLCQEMLMMNLIDPNELVQTVYSLAPFPFPGLDELREKYTYNITPFSPLGTDKAKKAMKMATNSDEEVELDEDDLAMAIGCFGGIFPPETSPKKKEGEQKPVSDMREVSPGAYSSRTEHIEMTRTALMERMSTDITALKKQYMRIRQKQQRTHLIYPKQGNENKSTSTHKFSATARDTPIAMNHLYVARKIASIQGKTKRIKGPEIRPAPQKGRHPTDGRREGVKKESGNEDSSGGVEIQIQWTSSMGRSTTERRSSEHSVESSVGSEGSENTGSKERESVDSREGSVMSDRTGMEEIQEEGKESEVCDTSDSEPELKSVPDREQNNTVEQNNTVLSPIQPSSEDETHDFMAREVGSACDSSSENDSTVPTETWKPLNTGETDVSSADTNKKKQRPTDLDLEAISNFSPKDPSPSSTSSNENQRPSSPTIPGIKSTKARPDSAGTNTAKFYPFPRPKQFKTAKTKNGVQLSLYKQTAENETVTSPTKGPFPVIKRSHINQCLQRQYMASASKTTTYR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase. When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.
Sequence:
MHLSAHIDPLQIILCTEIDEACIQFIKSQIEGIARACGPRMQANFEGVLIPYVDVLGKFLYRACCLRYATMGEEAARIVLAKQDRSKGLVLATTGERMTSLIFSLVIDLVGVHVNKLLKQASYSSSFKLPFGLRNLLPEAVISKEKHLVYILNSFKPILLKLVSIIRFLCLTMKGHCATVSQLLLGLKYISLDEINPEEKKKVLTLLLLLGSRLIASILQHSNSYFDQHTISSITDERDLEDKNKLPFIPEGNRKCSLCMEFIHCPAATECGHIFCWSCINGWTSKKSECPLCRAFSSPSKIILLR
The following text describes a protein:
Function:
Required for assembly of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSHKTPTRARSCYANSSTTSMNSTPSRNSFRPPSRLSLIPRSSSPIQPPRSRPSSAMSISRPSTPSMKSQEPYTGAITVSIRPNPNTIDNKNWSIDEFNNSIINTTDGTRFVFDNVFPMDRQLSNIQVYNKSCYNVVNKFLEEGYNGTIFAYGMTGSGKTFSMKGCENDPGFVELAINDIFQKINDNTTTKKYKMDISYLEIYNEKIIDLLSGSASSPTTSQSNQDLKIRDDVDFGTKVVGLTSANISSKPQLLQLIKYGDTNRKTSATDFNARSSRSHSILQIRLQVIDLLTETELKSTLSLCDLAGSERAATSLERRKEGSFINKSLLALSNVINKLSSSTLEHIPYRDSKLTRLLQPALSGSSLVSILCTIHMGGNQQNSQQCVAETYKTLRFAARAKDIVINVEKNMSHKLDGGDSSKMIQELNEIISKQRQEIIKLQSNTGVSSEKFENSRIVQLESENRVLIEKLDHLTRLTDLQKTETAIIKNDILNDILASGLDNSQILMTNIEDFYKKMTYEANEYKSYICRLETQLRLESINSTQQQQSSSPTSSIPMTNTTNDSSELMDALKEQEEEILMLKEQLKDKDQIIKSLSQTTRLRRLVGNNNNSTANSHNTYNTLDNDFKRHTTIVNFDKENYEPELRDFKLSPKKPKSNCDILESF
The following text describes a protein:
Function:
Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVSQRIRFVLVGTQHPGNIGAAARAMKTMGLTRLVLVAPEKALDEDAYRRSAGAEDVLSDAPIFETLAEAVADCTLVIGCTARARRVALEELAPDVGAGRAWAKAAEPAEVAIVFGRERTGLTNDELQLCHAAVHIPSDPQFSSLNLASAVQVLAYEMRLAQLAAEATPAAPAAPAADSAGPRELPASHAQMEGLFGQLGQTLDEIDFHKGRAPDSAMRKLRRLLLRAEMTEQEVRLLRGILADAQRMAGLARQAGT
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MTHVTLPILEDWEGLSLTTILQEKFHLGKKARHEIRMSQNVLLNNKPLDDWNTPLFVGASLSLPIFLHDKIPVYEYDLEIIYEDDFLLVVNKPVDMKTHPNDSYETDTCANAVQYYLEKTGQDANALAVHRLDQTTSGLVLFAKNKLAIAGLSWQMENRAIHRTYLAAVDGTWGLVMQTINKPIGEDRHHGSRRQISPYGQPAVTHVKVLENDNEKNTSLVECQIETGRTHQIRVHLSGIGHPIIGDTLYGGSPRANRIMLHAEKLHLNHPFKGKEMNFSAPAGDDWVF
The following text describes a protein:
Function:
Required for the maintenance of meristems and stem cells through the reduction of DNA damage. Promotes telomere integrity by maintaining telomere length and proper architecture of the chromosome terminus. Negatively regulates telomerase repeat addition processivity. Hampers contacts between enzymatically active telomerase and CST complex.
Subcellular Localization:
Nucleus. Chromosome, telomere. Note=Associates transiently with telomeres.
Sequence:
MAKSQIEPGVPITLQELYPSSLFYKEGVSLRVTAMLRGYSVETAIGVIEDGGRSLKINTQNIRDVSFRVGSIYQFIGELHIEQPNNEAILQARTGRNVDGIDMNLYRKTIELLRQFLKEEDNSNMVE
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Membrane; Multi-pass membrane protein.
Sequence:
MASSLAAQLSQIAAKSTNQLDLKAQRIAHSQSLIFDRKVASIQDFDTVYQICYEGFQELCQLDSRFTAFERTIFSEQSKAEDRTQLTAAQNKELDVALEAFLALVGGRLLLNPAIKAVEWLVRRFRIHEYNTSFTILTFLPYYTTPLFLNLLAILPEDLTPTFKVLIPYKKSSINPPRHPLVHSATTNKPFLAALNSYVLQVSRQQAHHHALLAFWAGVYTEAVAGMLDASRSGRREIEKQKHEDIVISVLPILNDGFAMKNVSELIIGCYMVSVVLAQKASLQDKVLDSLMEAVAGSWTEETVESGLVCLAVLAQQKPETKLPRRALKAILRLDDIFKRLTELATQYKTSHLLLGVVAGCLDDLPRQKDTARLDLLSQIFQNQLLGEPEMSKAMALVLEATSSVHKDGAMSLDAQARLADLVQVFSQSESLRPTFQKTIAESSFDIAALEHNLQTVIDTAPAPRTVEDVEMEDVEKEEEQDHFSSTVESLSGEKLFKGSFLSTQSIPLFEKLAQAFTLAIGSKEKCQTFSDLAALGKNEAEKSPQYLSFFIRVFSGPYSMGTRVTALNMITSFLTSTESTNLDFQALLPFLLVTLTDPSERVRREAAAALAAVGSLYKKNRKGEDIWARDNLYGQPKDIKWLPTRDAQKVFERAVLPSLEECIFDATHIGKVLENTLRGVSVDANASELKKPLRLAFFTFLCSHAIELPLFTPKLGLLNILNRIDKAGGTTRTKELEPLLKTWRGFSEREVQDICEKERVPVSDVERQMVAIVTPKEKDSIMILLSNVSSHSESLRPSFIAAVFGRIKDIWARVAEDRQTVAAEQLFDISLGLSDLPLVNNSRDLLRSVQLPGSVLAQFLERIPVSLTDMEALGPAPKRRRTSQNNMIAMTVKDEAEFGKVMEKMTFILELVDSSSPETHPELADGLFQTLAALHHFKSQIQSGMSYLLSLTLGSLLAIVNRSKESAKAQFDTSVIRADLVVDCVRTTESPQVQNAALLLVAGLSVIAPELVLHSVMPIFTFMGSSVLRKDDDYSVSVIDQTIDQVVPALIQSLRDQKRDVVSGTSELLLSFTAAFEHIPSHRRLRLFHALITKLGTQDFLFAVLAMLANRYAMDKDVLVLMTGLVSDASAPVELTTYSKFLGLVSDSLKPKPGISQVLLGIGSDDGREPQKVAVDLLRDLAYLFKHSSLKVKMAKTFASEDEEAIRQLRSTFSQILEQVLTIGDSVQSMKLVSQANGDVLAALFGTLTLVDFLDTIEVLLERPNDELRRKVLRLLEGRLRQNPERDSASQIRVLDFLPTLVDIIRNSTDILLKHAAVACIDRIAEKYGKKDPSRVIGAAQVVASEACIGQTDDRIRIMGVLCLASMAETLGQVMIPALPEALSRSLALLELSLEEGKENSRLHDAVFSLFSALFVHIPYMISGPHLDKILLLSFKSANAEECEDDSRQEALKMMARKVDMAATLGAVDRNWQYAVQAGPVATKETLEVVSLAVEKHPKSATGKNIGVLSSILFKAFDLRREQLALGANATFDAADVDETEDALNDVTIKMIYKLNDTTFRPIFTKMLDWATSGLPKKDTQGSLARLTAFYKFLQVFFGTLQSIVTGYASYIIESVVSVLGKASPADKSTKALWLATMRLLRNAFEHDQDEFWQSPSHLNQISTPLINQLAHATNSSTAATVIAEAVPAITELAVAADSTDNHKELNTALMKFLRPSAGPNGKPAGGENPHTRLAALKAEQSLTEQLGEEWLALLPEMLPYISELMEDEDENVEREVRKWVKQIENVLGEKLDDMLT
The following text describes a protein:
Function:
Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
Subcellular Localization:
Mitochondrion membrane. Nucleus. Secreted.
Sequence:
MAALSIALCRFGGVGSSLLSCYSQRLTGMRKAFASKTSGESALETDLEWDEEEQSDIIRKLKNQQKTILFQRMKRQMEPRGPPDRRLSWNAIEQIRYLKQEFPEEWTVPRLAEGFNVSTEVIRRILKSTFSPPERRKAKQDLKVSHVLMQTNPQSTKHLSQPTHTLLPDAVNPAQALIPSGQNNKLLSNTKNANLVPSLHSVPGSGNPKSLALRSGNEVVHKKKADLQVFTKKAQVQTPKSPMYDVCLTSEEGNQAEQKHLADHKPMELDDEWDGQLLSDVDLEELSRNGTENKMKVVRKGREFFDSNGDFLYRI
The following text describes a protein:
Function:
DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSIEMPSQSTTAGTSPKKHKSKSEKKHKSTDSEKKRKRENGEEGHRSKKHRSEKTAPTSSSTEATAEVSPFHLQTSSIFLPLAPVSQKFPLEGLCAEHLSPLILTYYPPFNGVILSYSNPRFAEKAFGNDGDSTLLQNLDEYAVSWAWVTAEFLLFKPEKGAWLEGYINLQSEGHLGLVCWNLFNASIERTRLPKEWKWIGVEDQEKNEEAEEGATYAEDGIGYYVDGEGKKIEGTVKFRVKEIESNHDKERGFLTIDGTMLDEEAEVRLLETEQDKVGSRDSAGRRLGGAKALGATSLGVTVEPSATEVDIGKKHRRRD