lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity).
Subcellular Localization:
Cell projection, lamellipodium. Cytoplasm, cytoskeleton, stress fiber.
Sequence:
MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDSEKQPVCTNPLSVLKAVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERTRHKQLSSMLVLECRKATSKAAEEGQKAGELSLKLDKEKSRASKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTRALKEEVESLKKLVKDLEAAQQHRSTSEQGREPVTMSRGTATEPPMRVSAFCQTESVQTERSHGSVITKLTDTGLPGPTTAAYSYAKANGHCDPEIQTTRELTSDSSTENQGPPREKSAVAAQEKPVENGGCPVGTETPVTMPSHLPSSGSSLSPSSTASSSLTSSPCSSPVLTKRLLGSAASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQSPPSRDLSPTLLDNSAAKQLARNTVTQVLSRFTNQGPIKPVSPNSSPFGTDYRNLASTASPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLTPSQSATTPVTKTHSQASSLAATEDLASSCSPSAVVANGKDVEILLPTSS
The following text describes a protein:
Function:
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Subcellular Localization:
Cell membrane. Synapse.
Sequence:
MDPEPPQTGHAVPVASASPDVALLTDTREGAGGGGDSAPRVAPGRERDDAPRPPEDSPSPDPQLVRPPRAMEGLGRERPDGPPQSGADYSFLVSQNMKLLSALEDLRHRCSSLTEENSLLRRSCFPETEEKVKHLKRKNAELAVIAKRLEERARKLQEANLKVVTAPVPLKGSSLELCKKAFARQRAKDLTEQASALLAKDKQIEALQQECRELQAKLIAGKGDPRCLNVVEFDRLLRESQKEVLRLQRQIALKNFKECLRPSKGSSGGSLPSAASCPGPALNACSKDSPAAKEVCSGGPALGGAAHGKVEPGVLPLGPALEGHENFPPKNAVADQESSQQIQQLEFELKKKRKKCENLEHEVRKKHKRCKELEIQLQEVQSENARLAEENLQLNEKAGWAGQVESENADLKLQVVLVTKERDSVIQRNQGLQTKLENLEQVLKHMRDVAERRQLLEAEHKEALLVLQEKQEEVRRLQQAQAEAKREHEGAVQLLEARVKDLEDQCRSQTEQFSLLSQELKQFRLQTGKIDLLTSTLVTSELPLALCSSTPQPHWEKDSPGPALLAHQSTKKVHNEETNESESSQRVPEAAVGSPVSTASSQKQAKKAESQSSSSKSESMQNSSKSCPTPEVDTASEMEELDVDSISLMPDPGSQGPAKLQVFLARYSYNPFDGPNENPEAELPLTAGEYIYIYGDMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLVTVLPSELNDLTHSSYQEKSFVSASTSSGDKSDFSIEESSISPLVSRAEGDQEERVSHTAVPYPRKLTLIKQLARSIVVGWEPPLMPAGCPDIQSYNIYVDEELRQNVKSGFQTKAVIEKLDLKTKAYRVSVQSVTEKGSSDKLRCTFYVGQDLCVAPTMLKVRNVTATSAEVTWLPCNSNYNHAVYLNGEECDITKPGVYWYTFCNLQPNTQYVAKLEARPLKTLWEEVSEGQEQNSAVIHFTTPLAGTPDAPLDVQVEVGPSPGILVISWLPVTIDAEGSSNGVRVTGYAVYADGQKAIEVTSPTAGSVLVDLSQLQMFQVCREVSVRTMSLYGESVDSVPAQISSVLLRASHRSSPSDSAVSTTLTSRLPCGESRGSLPARSPPTHQTAALLLRQKVPTDLSDAKLTDLSSSHDGSAQSLPEKASLLLQLSPSSASLVHTSGTSLQGSDTAQDKKCLTVPPQQAGSTKLLGEGTEPVSSREAELKSLGEGTEVLMEQNVNKMPELESPINASLMIRMETCHTCSVEESPTSPSAERETEAKEKNLSPEPLPSPSQAEEMEGTSRDASVGGSSCQEFLRLSPSKEVMKEMSRVKREQEEKMSEIGRRQLTLFTEHNRSSDLSDILEEEEEDELSSETLDEKKWDPREPCYRENGEKMDLCDTDSDEEILERILELPLQKNHSKKLFSIPEVTEDEDEDEDEKCVTEEKENPQGSLEAPTYIAGRSEKPLSTQDPFPKADGSDSSPDLSAQTPWEEQTAKGSRGGADHMSPSWSQKRTNWNWGYQENDLKSGSGTSPTRSKKKGNNYREKIRGRPEMGRKRQNDFTEHCSRLLGNCSQMGGGLYRAPSLREELNIVSSSAGKEGFDAYTRARQSASRRNHGKTMVSGFAEPAGMAAHCSSSRSLEIDIEYDSEDDQDSTCSSPPESRLWPERAQNCQGEWSDCSSQSEVFHTGGRRNLTRLERVEEQGMEWAGSPSRRLQSFCQEKEALRCESSSEEQGWEQDCKSPGWRRRLEHPWKGIRSTSLHKRASGNKDPRGQELPGSAAWQTPSRRGNRSLQRSQMQKPSLSSPGPPRSSASETTVEDDGIRIFVALFDYDPVSMSPNPDAAEEELPFKEGQILKVCGDKDADGFYRGECAGREGYIPCNMVSEVQVENNEIKMQLLKQGFLPADPPTESIGNGTFSPPPRRQTVPPPKPRRAKKAELDKQEKYKSHPGQKHQDFEAELLTPRSMVAVFDYNPKESSPNADAEAELTFSAGDIITVFGSMDDDGFYYGELNQQRGLVPSNFLEAVTSDGDVVEELHSKDKDTFLLSAESQLNPDGSVDHSDFSPTPPAPPSCLVMGEQCPEQASLAVLKCNDLPSQSKKKRGFFIKGKKLFRKLGSSKKD
The following text describes a protein:
Function:
Involved in the degradation of 3,6-anhydro-L-galactose, which is the major monomeric sugar of red macroalgae. Catalyzes the isomerization of 3,6-anhydrogalactonate (AHGA) to 2-keto-3-deoxy-galactonate (KDGal).
Sequence:
MIERVRTDLYRIPLPTRLTDSTHGAMMDFELITVRIEDSDGATGLGYTYTVNHGGAAVATMVDKDLRGCLLGADAEQIEKIWQSMWWRLHYAGRGGHATSAISAVDIALWDLKGIRARTPLWKLFGGYDPVVPVYAGGIDLELPVADLKTQADRFLAGGFRAIKMKVGRPDLKEDVDRVSALREHLGDSFPLMVDANMKWTVDGAIRAARALAPFDLHWIEEPTIPDDLVGNARIVRESGHTIAGGENLHTLYDFHNAVRAGSLTLPEPDVSNIGGYTTFRKVAALAEANNMLLTSHGVHDLTVHALASVPHRTYMEAHGFGLHAYMAEPMAVTDGCVSAPDRPGHGVVLDFERLGRLAVG
The following text describes a protein:
Function:
Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter that promotes recruitment of factors involved in TC-NER. Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites. Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II. Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II.
Subcellular Localization:
Chromosome. Note=Accumulates at UV DNA damage sites.
Sequence:
MDQKLSELVEVLTTSGEPQLNPEKLKELKKICRSSDEHINHVYHLLMTQLNQEHAEIRLSAFQIVTELFARSHLFRTLLISNFQEFLELTVETDHEQPLPPPKEVAQKMKILAIKTVQEWHEKFGEAYKKLSLGYHFLKQNKKIDFQDVRSRTQAERKREEEKQRRLENIYKEKVKKATAEMEDMLEEIQSSLTEMENCFRLLLPDPREFAVFTDEKDFASDMRTKPTSQSPSHSKSTSQSSAYSKSTSQVSFDNDDEQPCCSKNLPPFPSSCTSSASGAERSLGEGAKESDKSARKSDTDDSDGDYEGSREAFLRDHGLGSHAYSLSLEISTDLKVNENENNTDVLNNLMDAHKLLKQKYWPAVQSWIQLFTKAGTNSESLKCAIDVKKEIEAALKKYKEMNIDCHTKERKVMTASDDDDDDDEFEEVPEKEGYEPHIPDHLREEYGLEPSASKQPGKKTEVKRPNVPQVPPSQKRINDELNPTCAAATMKTMKDKMAKALPGSSRNAGEPKSKCPKRETDLSQAPVAPCGLDLHHWGEEQPSAGKMLKFSSLHRFWAPNEVDEEVESKELEALVKTRYVTLPGKFEPVKHKCLAPMPNGSLCERQDRYKCPFHGKIVPRDAIGVPINAEDRAREAREKFEKQGEEQDWRDPELMREIEQATGVDLGSSKCPVKGKGKGVKRNLKKKYPNLTDLKQKANTSRSRLEKKVFNTGSVKRVISAMNQADKRRHEKFANQFNYALN
The following text describes a protein:
Function:
SunT (TC 3.A.1.112.4) is required for production of the lantibiotic sublancin-168, probably by both processing the signal peptide and exporting the resulting mature lantibiotic.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNKKKKYVHTKQFNSHDCGLACISSILKFHNLNYGIDFLLDLIGDKEGYSLRDLIVIFKKMGIKTRPLELQENKTFEALKQIKLPCIALLEGEEYGHYITIYEIRNNYLLVSDPDKDKITKIKKEDFESKFTNFILEIDKESIPEKEKDQKKHSYFFKDILFRNKLIVFVILLTSLFVVGLAVAGSFYIKFLVDLIIPRSLRESLITITLIFISMVLIRCIFDFVRSYLIIKLSYKVDKEMSNVYFNKVTKLPINFFENREDGEVISRFNDGIYIKDFFSANFVTAIIDIILILGLGVILYRTNNILFLTIILPILLLSCLAILFFDHLKKKNQKLMEDKAKSTSLLINFLKNMTTVYSLNKTSFFLEKFHLTYDKQLNSTFSVAKAVISNEILKGLIQNSFTIIILWVGTRQVLNDSMSLGTLLFINTLAAFLLSSLDRILSMQSDLQQAHVASIRFFDVVNYPVQQDSNENLTELDFIQNIKTVNLNIGADPMRYIVEDINLILDRKDKVLIIGESGTGKSTFAKSLSKLYKVPDKSIYLNGLDINRYDHLSIRKRIVYIDENPFLFKGTIKENLCMGEIFDQNEIENACIMSQCHEFICNLDKQYSYKLSENGSNLSTGQKQRLALARAILHQPQVLILDESLSNIDPDNTKLIYETLHRMDCLIILITHNDPSNFKYNKKLVFRNNRIIESSYSENKEYSI
The following text describes a protein:
Function:
Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSNDRNAQELLKWGLANSGSTGVASFASQSVEQISADIEAGRRPDLADPNLYNAIMGKSEAQMMAEELSVAIDTSRTLPDRMTALDNFEMLIEQIDNANNMTSMKMWSPIISLLSAPEAEIQTAAAWIIGTAVQNNDKAQMAVLDFHPVAALLDLLHSHVDEVRAKAMYALSGLLKHNPAAMHQFDQLDGWNMLNMALVDPNLGLRRKTAFLINALLLQDPNSLDSQPASTSTATAIAPVSFTPPTPTAPPAPLERGPETLRTSIPHPNVARALVQSNIINTLISSLLPAHTLPDTLSPPPTGANGDSDARLDLDFAEKSAAAILTFTTKLPPSPSHPLDPTTISLFKALLVQLQAKPLDSSDPASTRWAELGIHAHDFDQFKHKIHAL
The following text describes a protein:
Function:
Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as a cell death activator during head development.
Subcellular Localization:
Cytoplasm.
Sequence:
MSANLAAIDELVEEFLKMELISVPPYPGQLGYLGSTKVNDFRTPLMPIPANNSNKNSNQSQRHQSQPQQREQQQQAASQQQQQLPSSQPLRSHHHNNSSSHHHHHHHHHHQQLLQREREAKQQQRELEQQQQQQQLLQQQQQRQQQLQQQQQQQQQYYSENQYPLEPATIALTASPHEDALQKLTQRLESELRIAKRQHLACTEVLLPADLLPRISAEMFEQSEKEPCGIRGCTIYIEFEDEPDNTRRIATMKTDPNTVSTFELYLTLKQDRRGWTSILPQFLKNLARGSTIMISPEFRLTKNKLYHAYAD
The following text describes a protein:
Function:
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
Sequence:
MSAIQPPKPVERKIELEPHQILLKPLVTEKGVHRATRNNQYAFQIHRDATKLDVKKAVEHLFDVKVLKVRTQTRKGKARRFKYKIGRTSDWKKAIVSLHEDHRIDFF
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGFDFSTSKSKAKRQKRIEVRFASPLMGIDLSLKLEAEEKKKEIEGSKHSRENKEDEEHDASGDEDEQMVKEDEDDSSSLGLRTREEENEREELLQLQIQMESVKEENTRLRKLVEQTLEDYRHLEMKFPVIDKTKKMDLEMFLGVQGKRCVDITSKARKRGAERSPSMEREIGLSLSLEKKQKQEESKEAVQSHHQRYNSSSLDMNMPRIISSSQGNRKARVSVRARCETATMNDGCQWRKYGQKTAKGNPCPRAYYRCTVAPGCPVRKQVQRCLEDMSILITTYEGTHNHPLPVGATAMASTASTSPFLLLDSSDNLSHPSYYQTPQAIDSSLITYPQNSSYNNRTIRSLNFDGPSRGDHVSSSQNRLNWMM
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Localized in the septal membrane.
Sequence:
MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSKHFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPNQTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELGNRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELEIGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE
The following text describes a protein:
Function:
Involved in polarity establishment.
Subcellular Localization:
Cytoplasm, cell cortex. Nucleus.
Sequence:
MMQIDYLLTAIFDPDRGPVLQYQCPENGEASDLHFLAELMLPDRVHERREDWSLFFIHFSKKSNVFSLFSNVDDINFEPSDSNMYYVLNTIRAKRVEGTRRGGSVFAMAICTTFPHVHALKPLLDTAWEIFDSSPSLKTLSMLHKSFNLHNFQSFYQKLSLDSSLILALNNFWSFFNLYLTNSPHIMNDIINKDIDNIPKPGSELIELSRDSYNSQATFCLSAESQERYVTCVIPSIHIPECVGEVSISNLINTFIDGPSPFMNTDISADINPINVLITALLISKKVLFLTKTSSASVLADFVLSSCALVSGATGLLQGLTRITFPYIDLSNVESLVKLPGYLAGVMNPAFTHHADWWDVLCDIDNQTIQVSSNLFSDATTTMDTKSLFNNTSPFTPISKDNQDDEIFIKDLRKFLKADDKETLVRWRVRLYIQSFIRKATSYEALFLESSPLNPYYKDYKFKGFGWSWDNDDEKVNELLYLAPKFEAWRQASTYKDYCYRLHCASTPVLRCMDIQFHLDRLRNSSLSTTDAAEIFLALESHIRTEEDVNYLLSNCPLHSGGLSVIAFGLYHISDKVRKAVSKLLNRIETHKYGKLFYMALNKVDISTHVYINSQHKKKKDSF
The following text describes a protein:
Function:
Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYSFMGGGLFCACVGNILLVVSTATDFWMQYRLSGAFAHQGLWRYCVTGKCYMQTESIAYWNATRAFMILSTLSCFGGVIAGILSFTNFSTFQKFNRSFTAGIMFFISTLFVLLAMAVYTGVTVNLLGKRFGDWRFSWSYILGWVALLMTFFAGIFYMCAYRMHECRRGSGPR
The following text describes a protein:
Function:
Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAGFKRKRDSSSEKGKKDKPVSSGDSSSESRSKPANSSILQLDNETSFPRGGASVLTPLEYKEVVNEAKRDALFTESKAKPEKKQTKQAARSKSKLSKKSKKTANADDDDEGSVPISHFSYKSVVEGTIVFGRISEINTLDLAVSLPNCLTGYVPITSISDSLSERLDKLDEVDEDNKSVAQESFPDLLDFYTVGQWVRARVTSITNDSSSKKKKRIELSLRPQDVNGGLGADGFVKGSVIQTVVTSWEDHGIAMDLGIEDFTGFLPLGAYNPETEFMEGQTVLCTVTSKKDRVFQLAMHQASPKALDKFPSVQAILPGNLANVLITDVLENGVTGKLMGVLNVTSDLMHSSLSQNERLANEFTIAKTRPARILYTIPSSPPTVAVTFLPHAVDFNKTSAEQENPLEKLPLGFTVEEAKVSAVSPSLGIFCDVGVEGVRGFAHISRLSDSRVDKVDPSSGDYQLHSTHKARITGFSFVDNLFVLSLQESIIDQPFLRVDDIPVGKVIKGSVVRLFAQGVIVKLSEGINGLVPTAHMADVQLHFPERKFKEGLPVKCRVLAVDSDRKRVLLTLKKSLLNSDLPIIDSYESVQPGAKAVGVFARILNTGAVVEFYNHVRGFLPTAEMSEAYIQDARDHFKVGQTVSVTVVNCDPETRKMRLSCREQNWTNERSQRFTDLEVGSVVSGAVSQKTENSVIVDLGNSVNGVIQVGHLSDGDAKKCQKILSKIRATTKLSEVLVLRKDLEKRIVFLTLKQSLIDAAKAGMLPKTLSDLKEGVKYAGFVKNITEFGVFIEFANGVTALAPKAYLSENYVPLPAALFKPFQSLTCVCFSIDMEKERALVSLKPLDKVNEKVDEITESKYVVIEPVDESITKAYDYTTGKLTWGVISSVKATQLNIDLAKNVHGRVDVSEAFDNFEDISDPSKPFSTFKKGDKIQVRVLGTHDAKNHKFLPISHRVSPRQFLELSIKPSVMKQTEFSGEALTFKKGDTCIAFVNNTTPECIWVSVGSNLRGRIAALDASNDLETLNSITEKFPVGSAIQCTVLSSGEILTLSAMEHVVDYETISAGDKLLGRISNINDMGMIVQLPGALSGRVSRTDVSDDFETSPNSLFSRNQFVRVYVLSVDVPNRKIALSTRASHFEEGKEIKDPEIKSFEDVEMNRVYRGFVTNVADTGLFVTLGRNVVGRVKIAELFDSFIKEWKPHFQVSQLVKAKVVHVDQEKKRIELSLKPSRVSSKEASAKEFSEIEVGSNVDGTVIRCEDFGVLIRLDGTDNIVGLCHKSEIADTTVNDVTKLYSAGDKVRAHVLSVDPEKRRVALGLKSSYFDADSDVDMYESGAEEDLESSADEEEDSDEAMDESAEEEVNSDSESESSDEEKEDAKGLEAAGFDWKADSTVFDKEASADSSDEDSDAEDGPQRKKKKNVKDDDEERDLDDAPQGPADFERKLLSEPNSSLLWIGYMAYHLGLNEIDKSREIGQRALKAINFREEEEKLNVWVALLNLEVAYGNEETLDKTFKEACHFYDELVVYERLCGILIKQQRLDLAKEYMERMVKRFSQIASVWLNYATFLMSNDDAEAARGLLQRSLQSLPKKDHVSTIEKFALLEFKQGDPERGRTIFEGLLSNYPKRLDLWNVLLDMEIKQGDVSIVRRLFQRLLANKLSLKKAKFVFKKWLLFEKDHGTPEGVEDVKQRAAEYVEQHQSDE
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGEGSSEKGTTCPTAPGPSTSGPAALSPMQQAAAAAAASAPPPSSTSSTASEPGGSSSSGQGKKVRIGICAMQRKATSKPMRAIMGKIVDYYNDWLEYFVFPEDVILNEPVEKWPLCDCLISFHSSEFPLYKAIEYEKLRRPYVINDLNRQYDLLDRRKVFRELARAGIEHPRHGVVIRDGKNELEGQLIEHSDHIEVNGMVFNKPFVEKPISAEDHNVYIYYPSSVGSGSQRLFRKGSRRTVARAAAEGHWFGLEINNRSSWYSPMSEVRKEGSYIYEDFIPADGIDVKVYAVGPYYAHAEARKAPGLDGKVERDADGKEVRYPVILSNKEKMIARKVVNTFKQTVCGFDLLRANGKSYVCDVNGFSFVKTSKKYYEDTAKILGNMIVRKMAGLLSIPYSIPCLGETAARERAKQPPVFDLGLGDDPPLVSTPSGKLMELRCVLAVIRHGDRTPKQKMKMIVTDDRFFALFRKYDGVKKNEIKMKKPNQLTEVLELSKELLCENQTRRNELLRALQEAEVEGNMQQMASIEHSLEATEEWVKKWDQVRTVLEMYGSGSGSCTMTVVDELMSGSGSGHDDSGSGSGAEEDAVVEDYHRSRGLNREARVEYGHFSGINRKVQLKYLKAREVRTPVEGESASSSSSSSALRQNGPASDSCPAGPTHTPSTMPPTGPALQLILKWGGELTTAGSLQAEALGKLFRTLYPGIRRTDGKNSPEDTQGLGFLRLHSTYRHDLKIYASDEGRVQTTAAAFAKGLLALDGDLTPILMQMVKSANTDGLLDDDCHARDFQQDLKKILHQALQDDVDWTPDDYATLNPSGLKSINNAMEFIKNPKKMCFEIAGYVKRMVEVIQWHRENRATMTLYLNESWDLAERRWSKYDMEHNPDLCINKEEDFERFYLCVKNMADIVVPQEYGIEQQNKILVAQRVCTPLLKKIRNDLHRCIQEDEAESQTRLDPRASQGIATPLRHVRTRLYFTSESHIHTLMNLIRYGGICSVDDKKWNRAMNFLSGVTEFNYMTQVVLMVYEDSSSEAKGMDRFHIELLFSPGLYPCFLTEKERIYENRFNKSNGMTKSHSKDLKDKRENGDESEKERESGSLSPPIRLSSNASSLLTSSTDCLSVSSTTTPSTIIAPIVTTPTRDSSSLSVSSLSTSPGGVGSGGSARSSEGAAATAAVTPMTVEKKASVGTTSSSTVVGSSHHESDEELNDHLSVNLVVLDEVHNKPYDTERARGAGGNEKASEEGDAPRGDLNKKHSSTVPLLVAPPLLPKPLAILPSPKAASSAAAAAAAVPAAAPSPTAAEPEANEDHQARYLCDTFWGTATVGSGRGKWVHELLEETKKAMEEQKKKSQSVIQEEEEKKDTVACTLGEHRRDSGSLEAWEAWLERPQPLGDLWARRSRFPYRFKHHTVNLLSGGSDVDRLISTDVIRGKLSACGSESEKRRLSNSPAVLSTAVIARSSSAPRLQTYKVDEEISVTEIRRFWPPLRSLETLHDCLSFTQLDSFLCSRQRAGRGDGDRPPAAPPDRYDAQSESLNVSTVLDRPASTMADTSPELSEDEVEYEEDFRSTEGGDDRTWTGTDGRSTDTEGDFGLLNVESKFMSGMSVDENEDENEDRAIGGQDEDRFFPSPVSPRLFAGGDPPRKTGPKTAAYCLAMKATFDVLMTSQSVNEEPEHDDRPPAQLLKACYVDLSLEPPIVRKVYAALEKSLVECECGRPYYPKPLTSCARVRVPNAKAVCTEDVPTVIRVIFVCESCRSVSRTRMRIPLADLDARTVDVINHVIEPTRTPPPPPPIECAREEDEGVTMCYCDGYRIFRNTNPIPKKIIIS
The following text describes a protein:
Function:
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg) (By similarity). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells.
Domain:
The fork-head DNA-binding domain is essential for its dimerization and interaction with NFATC2.
Sequence:
MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDLRSGAHTSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHAQTPVLQVRPLDNPAMISLPPPSAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREAPDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPNKCSNPCP
The following text describes a protein:
Function:
Exhibits phosphohistidine phosphatase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MCTQTRAAALMANIPEADIDPSGVFKYVLIRVHSREEGDDSEVDIVRGYGWAGYHGAFRDLSHPDTFLSQRCTNCLSRLQRTSMIRSPRSWRRAESWTVSVLEEGGSNTTPKRRRSTCTDTRRDLGGPTTRWPPRS
The following text describes a protein:
Function:
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MLAHMPAARTFLQHPDPLTREIAEGYAGGSFLMDNGDGLRWYGVPGRALVPLTEDAGLHVARRMRRELKHFRPSVDLAFDEVIAGCRGHLPGSPERDGEWISDELVEIYQHLHTTGLAHSFEVWQGDELAGGVLGLALGGAFIAESKFHRLTNGSKAALIHLAEHLDRQGFALLDAQIQNPHLATLGVYEVTDKEYRRLLRRALALDVEL
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MQMMLMFLLLLAAIMVIRATSPYYGALATAWLALLAALLLLDADIIFPAIILMLIYLGGMLVVFIYSTAYAADLMPLPINLTMSALMASFGVMLITMISSPSIETLCETKPWLVYDMQPSYMLFDIYQRGSSMFIVAVMILTALLFSILEVVSHRQTTMKWFIHSTY
The following text describes a protein:
Function:
Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation. Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors. At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity).
Sequence:
MVNPGSSSQPPPVTASTLSWKRCAGCGGKIADRFLLYAMDSYWHSRCLKCSCCQAQLGEIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMRAQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLPDQKVC
The following text describes a protein:
Function:
Possible microtubule-based motor that can interact or substitute with myosin 2 (MYO2).
Miscellaneous:
MISCELLANEOUS: Present with 1920 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MHWNIISKEQSSSSVSLPTLDSSEPCHIEVILRAIPEKGLQNNESTFKIDPYENTVLFRTNNPLHETTKETHSTFQFDKVFDANATQEDVQKFLVHPIINDVLNGYNGTVITYGPSFSGKSYSLIGSKESEGILPNICKTLFDTLEKNEETKGDSFSVSVLAFEIYMEKTYDLLVPLPERKPLKLHRSSSKMDLEIKDICPAHVGSYEDLRSYIQAVQNVGNRMACGDKTERSRSHLVFQLHVEQRNRKDDILKNSSLYLVDLHGAEKFDKRTESTLSQDALKKLNQSIEALKNTVRSLSMKERDSAYSAKGSHSSAYRESQLTEVLKDSLGGNRKTKVILTCFLSNVPTTLSTLEFGDSIRQINNKVTDNTTGLNLKKKMDLFIQDMKIKDDNYVAQINILKAEIDSLKSLHNKSLPEDDEKKMLENTKKENIKLKLQLDSITQLLSSSTNEDPNNRIDEEVSEILTKRCEQIAQLELSFDRQMNSNSKLQQELEYKKSKEEALESMNVRLLEQIQLQEREIQELLTTNAILKGELETHTKLTETRSERIKSLESSVKELSLNKSAIPSPRRGSMSSSSGNTMLHIEEGSEISNSPWSANTSSKPLVWGARKVSSSSIATTGSQESFVARPFKKGLNLHSIKVTSSTPKSPSSGS
The following text describes a protein:
Function:
Catalyzes the reversible interconversion of fructoselysine with its C-3 epimer, psicoselysine. Allows E.coli to utilize psicoselysine for growth. Does not act on psicose or fructoselysine 6-phosphate.
Sequence:
MKTGMFTCGHQRLPIEHAFRDASELGYDGIEIWGGRPHAFAPDLKAGGIKQIKALAQTYQMPIIGYTPETNGYPYNMMLGDEHMRRESLDMIKLAMDMAKEMNAGYTLISAAHAGYLTPPNVIWGRLAENLSELCEYAENIGMDLILEPLTPYESNVVCNANDVLHALALVPSPRLFSMVDICAPYVQAEPVMSYFDKLGDKLRHLHIVDSDGASDTHYIPGEGKMPLRELMRDIIERGYEGYCTVELVTMYMNEPRLYARQALERFRALLPEDER
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
Subcellular Localization:
Cytoplasm.
Sequence:
MAERRVNVGWAEGLHARPASIFVRAATATGVPVTIAKADGSPVNAASMLAVLGLGAQGGEEIVLASDAEGAEAALERLAKLVAEGLEELPETV
The following text describes a protein:
Function:
Peptidoglycan polymerase that is essential for cell wall elongation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MQNNIYLKKISKFSVFFIVNILLLFIISLSTIYSATITKSEPFFLKEIVWFIISIFVFIGVSLVDYRKYYKYATAIYIFNILMLLSVLVIGTSRLGAKRWIDLGPLALQPSEFSKLFLIFTFSAYLINNYSDRYTGFRAMFMSFLHIFPVFFLIAIEPDLGTSLVIILIYGMLLFLNKLEWKCIATVFFTIAAFIPISYKFLLKGYQKDRIDTFLNPELDALGTGWNITQSKIAIGSGKIFGKGFLNNTQGKLKYLPESHTDFIGSVFLEERGFLGGSMLLLIYIVLLVQIIYIADTTEDKFGRYICYGIATIFFFHIFVNMGMIMGIMPVTGLPLLLMSYGGSSLVFSFLILGVVQSVRIHRGSK
The following text describes a protein:
Function:
Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.
Sequence:
MAASQSYRFSPARASRHSPALSPATNTTLNKRWQGNYSQHASNKAARLSVHEAAAFSSPPTLKAWSPSSPMANPGPPRELKKLCVFCGASSGTDPEYMAAAKALGEYLVKEQIGLVYGGGTVGLMGEIARTVQAGLGDEGVLGVIPEALTPREVSGSLIGKTHIVEDMHTRKALMAQHADGFIAMPGGFGTLEELMEVVTWQQLGFHAKPIALLNIRGFYDPLLAFVKHAVEQGFIRPMHNNLIVSSEPEELVAAMRAFTPPVSLVASIMNSTAPVGRDVSLSSQEADKQLQQQQQ