lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the secretion of alkaline protease.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MARLGSSVTNEIKQALAASRGALRSVAAFSGVINLLMLVPSLYMLQVYDRVLSSANEVTLLMLTLMALGVFVFMGALEALRSFVLVRVSERFDGQLHGRIYAAAFERNLRAGGQEASQALHDLTTLRQFITGQALFAFFDAPWFPVYLLVIFLFDPWLGLLSLVGALALMALAWFNERATRAPLAKAGELSIKSGQLASNNLRNAEVIEAMGMLGSMRGRWERLHQAFLDQQSLASERAARINALSKYLRIALQSLVLGLGAWLAVEGRITPGMMIAGSILMGRALGPIDQLIGVWKQWGAARDAYRRLSGLLDEFPARERRMELPEPRGHLLLESLDAAPPGSEARTLRGLTLAIPAGSVVGVIGPSGSGKSSLARVVLGIWPTLHGSVRLDGAEIRQYERETLGPRIGYLPQDIELFAGTVAENIARFGEVQADKVVEAARLAGVHELVLRLPQGYDTVLGVGGAGLSGGQRQRIALARALYGAPTLVVLDEPNSNLDDSGEQALLAAIQALKARGCTVLLITHRAGVLGCADRLLALNAGQLHLYGERDQVLAALNNQRAASASQQRADYRVAGYGAPQVVAAPRQGGVE
The following text describes a protein:
Function:
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Subcellular Localization:
Host nucleus inner membrane. Note=Remains attached to the nucleus inner membrane through interaction with NEC2.
Sequence:
MYDIAPRRSGSRPGPGRDKTRRRSRFSAAGNPGVERRASRKSLPSHARRLELCLHERRRYRGFFAALAQTPSEEIAIVRSLSVPLVKTTPVSLPFSLDQTVADNCLTLSGMGYYLGIGGCCPACSAGDGRLATVSREALILAFVQQINTIFEHRTFLASLVVLADRHSTPLQDLLADTLGQPELFFVHTILRGGGACDPRFLFYPDPTYGGHMLYVIFPGTSAHLHYRLIDRMLTACPGYRFAAHVWQSTFVLVVRRNAEKPADAEIPTVSAADIYCKMRDISFDGGLMLEYQRLYATFDEFPPP
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MASELENLNPSARIMTFHPTMEEFKNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRRWYDDIDDVIIPAPIQQVVTGQSGLFTQYNIQKKAMTVREFRRIANSDKYCTPRYTDFEDLERKYWKNLTFNAPIYGADVNGTLYDKHVDDWNIGHLNTILDVVENESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYCVPPEHGKRLERLAKGFFPGSAQNCEAFLRHKMTLISPSILKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIEYGKQSVLCSCRKDMVKISMDVFVRKYQPDRYKLWKAGKDVTVIDHALPTPEAAEFFKGELLQKVKNEKHCPDDTELEEECSADGDIEKKSMPKHRIGTKRHRVCLEVPHEVSQSEAFPKEELGPVQFEMDVAESPVGPAREPVQQGEQGIALPEYGDSSEVKFEELKNVKLDDEEEEPEAAVLDLSISHSVTSTGIKLQSSVSSLQSDSPMGSGSSDSEPSDLYRQDLEQPEVLMVHSYAKEEVNDMSSERPSGKKASATTRVNEQDLAKMAKEYIRSVKDHKKSKGRRQPLSKLPRHHPLLVKDGLSDDEMSEQLNPEEEAEETEAWAKPLGQLWQNRPPNFEAEKEYNAAMAQQAPYCAVCMLFQTYQADCGGQSSQVVLDAGGKMRTKPLIPEMCFTTTGCSTDVSLSTPYLEEDGTSLLVTCKRCRVRVHASCYGVAPEKATGDWKCSRCRANALEEDCCLCSLRGGALQRANGNKWVHVMCAVAVLEAKFVNIAERSPVDVSKIPLQRFRLKCVFCKKRRKRTAGCCMQCSHGRCPTSFHVSCAQAAGVMMQPDDWPFVVFTTCFRHKIPSQAERALQDLVVGQAVISKHKNGRFYQCEVINLTKETFYEVNFDDGSFSDNLYPEDIVSRDCAQLGPPAAGEVVQVRWTDGQIYGATFVASHVIQMYQVEFEDGSQLMAKRDDVYTLNEELPKRVKSRLSVASDMRFTEIFTEKEVKQERKRQRVINSRYREDYIEPALYRAIME
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MSFVPPPASSTTHAQREVELTLLRFLEKYRPEVCDLWGTHSNIYLHADSNEKEEEMCTIDNEEGIVHSLNRESHEKYLKSRLVKLPEYAQRLYNAQPWMVYWTLQAAEMLGITEKLYEQISQDALGEFILSCLQEQPVEDEQKGCWGSEEGGKHGKGSMPQQCGNVYDFLRRCDADHTCAIGFSGGNYGQIPHLATSYAGVCSLCILECPEYLQALPRSAIKRWLLSLRCADGSFRMHIGGEADIRASYCVAVITTLLQLQDVDASSGDILREQEAQFVASCQTHEGGFACGRFASEAHGAYTQCGLAALILMKRPELCNYTALRGWLAARQLRFEGGFNGRTNKLVDSCYAHWVGASHVLLRVGESLAKITTCGETKRSLTSREMLLLDHAQLVDISNLHPESFEAWSQHEEEKQERASRVEAYLSATPLAASWSSSGVPNVLDDDAGDFYFNQRRLQLYILACCQNREEGGLMDKPNYPNDFYHTCYSLSGMSSAQNLQGMQVNRDGRDLSGNSFYAAAVSRGYIPGRRDSYGIVLPSDERSGVSSELHLSKNCLRPTNPIFNINQSKVLFALRTWGAKTFMC
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MGSAKVVVAGSINMDIVVRAARHPQPGETLLGQSVQFFAGGKGANQAIAAYRLGTPVILIARVGDDGFGGSLRAFVSQEGLDTQRVLATAGASGTALITVADSGENTIVVVPGANDALSPVDVEVDIEPGDVLVSQCEIPAQTIEHFFVRGKRLGARTLLNAAPARPLAPTLAAAADVLVVNESELAILTGAAVDAEDAGTVIAAARSLQPAIENVVVTLGGRGAVACLGPVSETVPGRRVEVVVDTTGAGDGFVGALAARLAAGEPFAQALVFANAAASICVERPGAAASMPTMAEVLAVL
The following text describes a protein:
Function:
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (By similarity). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity).
Subcellular Localization:
Mitochondrion outer membrane. Mitochondrion.
Domain:
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence:
MAIQFRSLFPLALPGMLALLGWWWFFSRKKDRLSSNGKQVGTLKVGPAIEDRLPTEEACPGVLSVTPSVTQPPGKEEQRSMDRPLSDPPALPRTRQVRRRSESSGNLPSIVDTRLQAGQCSDENSKVVLSLMGDEAKSIPLGRPLFPKDLSFPYEAVEGCKQESALGRTPGRGWLSQCAASGENARETGGAEGTGDAVLGESVLEEGLLPQECVSEVEKSEFPILAPGGGGGEKVRSGPPQVDELLKKEEYIVGKLPSSFVGPVHSELVKDEGALVPQVKGSQDRSLARELDKDKTLPEKDQIEQTAFQIISQVILEATEEIRATTVGKTVAQVHPTPGTQPQGQEESCVPASQETSLGQEIPDPASTRTGATASPSAGAPPPKTYVSCLSSPLSGPTKDQKPKNSAHHISLAPCPPPVTPQRQSLDGASNPRGDDTFVTCTSNNSQSVLSVTSLGLCSDPVSTSRLEDSCTETISSSGDKAVTPPLPDSTEPFSNGVLKEELSDLGTEDGWTMDTEADHSGGSDGNSMDSVDSCCGLTKPDSPQTVQAGSNPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGSQHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVVPLSDDDHFSPEADAAMSEMTGNTALLAQVTSYSATGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSCYASL
The following text describes a protein:
Function:
Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.
Sequence:
MLVLNCSTKLLILEKMLKSCFPESLKVYGAVMNINRGNPFQNEVVLDSWPDFKAVITRRQREAETDNLDYYTNAYAVFYKDVRAYRQLLEECDVVNWNQVFQIQGLQSELYDVSKAVANSKQLNVKLTSFKAVHLSPVSTLPDTSFLKGPFPRLTYLTVAEADLLNRTWSRGGNEQCLRYIANLIACFPSVCVRDEKGNPVSWSITDQFATICHGYTLPEHRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNTASIGLLKSLHAEFLPCRFHRLILTPATFSGLPHL
The following text describes a protein:
Function:
Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.
Sequence:
MAPGEKKRGDGPAKSALRKVHTATLVITLARGWQQWANENSIRQAQEPAGWMPGGTQDPADASGPAIDAPSRWKAQRAPKPSSPKPEGCGEDGRGSEEASAVSPIKRKEVTKTVVSKAYERGGDLGHLSHRYEQDGDQPETRQPESDVDRLLRSRGSPTLRRKCAKLVTELTRGWKAMEQEEPKCRSDSVDTEDSGYGGETDERPEPDGEQVAVARIRRPLPSQANRFTEKLNCKAQRKYSQVGNLKGRWQQWADEHIQSQKLNPFSEEFDYELAMSTRLHKGDEGYGRPKEGTKTAERAKRAEEHIYREILDMCFIIRSMARHRRDGKIQVTFGDLFDRYVRISDKVVGILMRARKHGLVDFEGEMLWQGRDDHVVITLLK
The following text describes a protein:
Function:
Involved in suppression of photomorphogenesis in dark-grown seedlings. Probably part of the COP1/SPA E3 ubiquitin-protein ligase complex.
Subcellular Localization:
Nucleus.
Domain:
The protein kinase domain is predicted to be catalytically inactive. The DWD box is required for interaction with DDB1A (By similarity).
Sequence:
MMDEGSVGDVSRIDEADVAHLQFKNSEQSFKPENIEVREVKEVQVQREAGSPDCSYGVIADFLDGKNGGDHVELIGNEPCSSRQNTNDEGDVVEELTVKTCEGSSMAIVGRPSSRARLEMNRSQFLHRFPLDGDLPGSSSMSKKVIDRGTVSILRNAGKMSLPETSNGQLAIIAVNGEANEHLTNVERNPVPVEALSHEGIKTKMLSQSGFSQFFVRKTLKGKGVTFRGPPNNRSKARNMDQQTVASSGSALVIANTSAKISSSIPLAAYDGLPCLPSNTSKPSSCANPSDTHRGCGGEGLSLREWLKSERQEVNKAECMYIFRQIVDHVDCSHSQGVVLCDLRPSSFKIFKENAVKYVVSGSQRESFDSNMNKETLSQLENPLVRRRLGDTSSLSIPAKKQKSSGPSSRQWPMFQRAGGVNIQTENNDGAIQEFHFRSSQPHCSTVACPFTSVSEQLEEKWYASPEELRGDMRSASSNIYSLGILLYELLSQFQCERAREAAMSDIRHRILPPKFLSENPKEAGFCLWLLHPESSCRPSTRDILQSEVVNGIPDLYAEGLSLSIEQEDTESELLQHFLFLSQEKRQKHAGNLMEEIASVEADIEEIVKRRCAIGPPSLEEASSSSPASSVPEMRLIRNINQLESAYFAARIDAHLPEARYRLRPDRDLLRNSDNTVAEVENSETWSSDDRVGAFFDGLCKYARYSKFETRGVLRTSELNNTSNVICSLGFDRDEDYFATAGVSKKIKIYEFNSLFNESVDIHYPAIEMPNRSKLSGVCWNNYIRNYLASSDYDGIVKLWDVTTGQAISHFIEHEKRAWSVDFSEACPTKLASGSDDCSVKLWNINERNCLGTIRNIANVCCVQFSPQSSHLLAFGSSDFRTYCYDLRNLRTPWCILSGHNKAVSYAKFLDNETLVTASTDNTLKLWDLKKTTHGGLSTNACSLTFGGHTNEKNFVGLSTSDGYIACGSETNEVYAYHRSLPMPITSYKFGSIDPISGKEIEEDNNLFVSSVCWRKRSNMVVSASSNGSIKVLQLV
The following text describes a protein:
Function:
Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). At the metaphase-to-anaphase transition, recognizes and binds proteins containing a D-box including the B-type cyclins CLB2 and CLB5, HSL1 and securin PDS1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for sister chromatid separation and disassembly of the mitotic spindle. Target of the spindle checkpoint pathway through participation in the mitotic checkpoint complex (MCC) and the MAD2-CDC20 subcomplex. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 until proper attachment of all chromosomes to the spindle.
Subcellular Localization:
Nucleus.
Domain:
The KEN box is required for the association with the APC/C complex; The C-box is required for the association with the APC/C complex; The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Sequence:
MPESSRDKGNAAISGNRSVLSIASPTKLNILSSDWSRNQGKVSKNSLKRSSSLNIRNSKRPSLQASANSIYSRPKITIGAPPLIRRDSSFFKDEFDAKKDKATFSAYSSRSYPTIGSESVVSQTSLSQPTTSREVDEQFTVAADRYIPILQGASQNKVDPETLHEALPPPNASPISHLRAQTKIVFKQNVAEACGLDMNKRILQYMPEPPKCSSLRQKSYIMKKRTHYSYQQEQKIPDLIKLRKINTNPERILDAPGFQDDFYLNLLSWSKKNVLAIALDTALYLWNATTGDVSLLTDFENTTICSVTWSDDDCHISIGKEDGNTEIWDVETMSLIRTMRSGLGVRIGSLSWLDTLIATGSRSGEIQINDVRIKQHIVSTWAEHTGEVCGLSYKSDGLQLASGGNDNTVMIWDTRTSLPQFSKKTHTAAVKALSWCPYSPNILASGGGQTDKHIHFWNSITGARVGSINTGSQVSSLHWGQSHTSTNGGMMNKEIVATGGNPENAISVYNYETKFKVAEVVHAHEARICCSQLSPDGTTLATVGGDENLKFYKIFDPRCTGRSREDGLMDGMLGLIGKEGCRTNDKENRSKNSSEIHTRRPSSTSQYLIR
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MADPGTENGSDALARLASVRGLNSAEDVVMQWDSNSSDHARQSKIWEGLQHESDAYLEAVDEIQTALESLTVGGNNQKELTRAQNLCQLAMTRLEEELRHLLLTCSEPIDPEWLVDNCSRAGSFNSRRLDDAEGGNDFDADVNDDVDAGVDGEVDAAERPDDEEQREDKPFSRPVGNVNPVLDFIPPATVLDLTNIVKRMIIGGYERECVQVYASIRKNVLEETLTLLGVEKLSIDEVGRMKWEDLEVKISKWNQRMKVCVRALLASEKHLCESVFANAPVSVACSCFNELGKGPMMQLLSFGEAVAISRRSPEKLFKILDMYETIRDLLPDIKDTFCGEACAPLRADVEAILARLGECAKRTFGEFEIAIQRDGSRIPVPGGGVHPLTKYVMNYIKFMCDYSDTMKLLFDEKEYDLDDEGGNESSREGSFRDGSLRDSPRYSSRSNDGERGGSTELSTLGTQTIWVTKVLLSNLEEKSKLYRDLSLTYLFLMNNIHYIVQKVKTTEVRAVVGDDWVRKNTSQVRQYASSYQRAAWGKILSCLRDEGIHTGGGFSSGVSKPVLKERFKSFNAAFEEVQKAQTSWVIQDDQLRDELRIAISDKILPAYRSFLGRYGHYMETQRHPERYIKYTSEHVEEFLNNLFEIHSPSLSSRDLRRRSSHHGSSHHGEASGRTLCSSSDEAIIMYSAV
The following text describes a protein:
Function:
RNA helicase.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MADLILNFETEPAPAQPKARHIHTTPGSWTHKHKQKRRAKHLDRLNAQPKTTATTTTSSTQSQPQNSKRNQDEDQGTETLPESRKKPKLDNVSKPAGRLQIISSLFSSTIIPTIKPISNDEQSSMVVYAPSNASLSEIQVTSTSLKLHPQISKHLSTNSKVGPVKSPTAIQSIAWPLLCAQSNTSTRDVIVQSETGSGKTLAYLVPIIQDLLTLTKNHPEISWSREIGTLAIILVPTRELAEQVYHVAIDLLSFAQRSGTSSKEVEGEETPPQDEKSVERETAADGLNPRWLVPGTLHGGTNRTHEKARLRRGLPLLVCTPGRLLDHLEKTVSLRMAGEPIPPSNDPNAKAKVDPRSIGHLNLRWLVVDEADRLMDMGFEEQMRGILKHLTDREAKTNNPNKVPLSSSSSSSNARRTILCSATMPDGVKKLVGLSLNDPILLRATGPNPEEDQAEDGSKDAVAKSENTTFSAPTQLSQYYVLTPPKLRLVSLIALLRRITDSKQKKPAEKVLVFMSCTTSVDFHFEALGCASTAESTKTTSTDPENEEAEPNKLVKQSKFLPGVKIFKLHGNLDLQTRLASLNAFSTSDTKSQGSSILLCTSLAGRGLDVPFVSHVIQYDLPTEGGVTEYLHRVGRTARAGQAGEAWSFLLPSESGWVDWCESNQNESVGGPKLKEIGVETLLDDGFGGHNKSPKAWEVRATDTQMMIERWVVGKEENLNLASMAFSSHIRAYATHPSQEKRFFHVKNLHLGHMAKAFGLREPPKKITSLYPQQKTSSKSAKAINPRQPPATNPKISSANKKRNGKDARDSSGSEEEDDEDDDQHPPLTSFKALSQFKHVKNGNTLRGPIFNSIDEFNLG
The following text describes a protein:
Function:
Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol. Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex.
Miscellaneous:
MISCELLANEOUS: The binding of a cargo to PEX7 is necessary but not sufficient for the targeting of the complex to the peroxisome. PEX12, PEX13 and PEX14 play a critical role in this targeting. PEX7 is required for PEX5 stability in light-grown seedlings.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix. Note=The loss of PEX12, PEX13 or PEX14 prevents the targeting of PEX7 to peroxisomes.
Domain:
The WD40 repeats are involved in the binding of PTS2-containing proteins.
Sequence:
MPVFKAPFNGYSVKFSPFYESRLAVATAQNFGILGNGRIHVLELAPGAPGVTESVSYDTADAVYDVCWSESHDSVLIAAIGDGSVKIYDTALPPPSNPIRSFQEHAREVQSVDYNPTRRDSFLTSSWDDTVKLWAMDRPASVRTFKEHAYCVYQAVWNPKHGDVFASASGDCTLRIWDVREPGSTMIIPAHDFEILSCDWNKYDDCILATSSVDKTVKVWDVRSYRVPLAVLNGHGYAVRKVKFSPHRRSLIASCSYDMSVCLWDYMVEDALVGRYDHHTEFAVGIDMSVLVEGLMASTGWDELVYVWQQGMDPRAS
The following text describes a protein:
Function:
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
Subcellular Localization:
Cell projection, dendritic spine. Cytoplasm. Nucleus. Postsynaptic density.
Sequence:
MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPLVKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQQSSVCEIWTNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF
The following text describes a protein:
Function:
Involved in mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MEQKNLNINQASGSKINTELAVPIFQSRRRHRPRQGLKRKKGFKRDDDSGGSSESSNEDMRDNIPIVSGRKKTVRLNRLQRESEQFENSALKDINVEYQSNLSATGESVNTTTVSAINEDTREVILGRPSPKLANQSTLPTELFQSQNDYSRFLPKRKDFEKKSQVGPVLSSNASTVRMNTIIDYQPDVCKDYKLTGYCGYGDTCKFLHMREDYKAGWQLDREWDSVQEKYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYRSPIATTCGHHFCEQCAITRYRKTPTCIQCGADTKGLFSVDKNFDRLLKNRKSKNDEAVKQKVGGFESNNSATTEVSERKDREASFQGFADTLAKPNTSAQQKMPSLGDNSNTIISKYFIREITESNIVHFKRLVRVVLEASYSDKFYRLVLKNPDYARIATFEDKFVGAISSLVAEDNSLYVTVLCVLAPYRCLGIGSLLIDHVKKTAINNNIDRISLHVQTTNESVIKWYTAHGFKIVKQINDFYRRLENKSAFYMVCPLSAHNNIISNH
The following text describes a protein:
Function:
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Sequence:
MEKNSQEKVLNVFENKQKDNYPLTNQISQDYEDDTHVYRIIRLGKESVKLMQDYKLLKEKEWRKLKVQQSRGWLHYAIFEKEPYVLLFKRKITKNKR
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MPIQVETIGYYHRDSELNITPNLLPKVLNENKKYLEDPTLPFPYVDVQLKVPDNGGGEKHMESVLSYLNQMGWPNKKKPDFVTNRHTITTIATTGFSSKEQAQRLLIFRYSGVIFLLKSSEFDDLTPDILNYAIKFEHFFKKTSDEEPVGGDGTVRKAVFKATIPRGNEHPYSVLYSGEMDAIYDEESREHVELKVFVNGLDNYKWKFRSCWMYWQAFFSNVPTLVIGSRTGKEYQSISKHIPGFSLYKVEKLERDSIPSTAAAKHAQRMGDRPFPPKIWSVAAGERHLRVFLQLVKETAISDGDCFVLSRNGERSRWIIERDEESVAEFRKVIVKSMPK
The following text describes a protein:
Function:
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.
Subcellular Localization:
Early endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, autophagosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2 (By similarity). Localized to Salmonella typhimurium entry sites.
Domain:
The VCA (verprolin, cofilin, acidic) domain promotes actin polymerization by the Arp2/3 complex in vitro.
Sequence:
MTPVKTQCSLAGQLYAVPLIQPDLRREEAIQQVADALQYLQNISGDIFSRISRRVELSRRQLQAISERVSLAQAKIEKIKGSKKAIKVFSSAKYPAPEHLQEYGSIFTGALDPGLQRRPRYRIQSKHRPLDERALQEKLKYFPVCVNTKSEPEDEAEEGLGGLPSNISSISSLLLFNTTENLYKKYVFLDPLAGAVTKTHTMLGTEEEKLFDAPLSISKREQLERQAPENYFYVPDLGQVPEIDVPSYLPDLPGVADDLMYSADLGPGIAPSAPGAIPELPAFHTEVAEPLQPELENEVLLAAPPPPPPPPPPPPPAPTALVSTPQPPMFPDMATAAGQVAREEDSSSSMAHTASVQGAPKEVVDPSSGRATLLESIRQAGGIGKAKLRSVKERKLEKKKQKEQEQVRATSQGGDLMSDLFNKLVMRRKGISGKGPSTGTSEGPGGAFSRMSDSIPPLPPPQQPAGDEDEEDWES
The following text describes a protein:
Function:
Transcriptional regulator. Binds to specific sequence motifs in regulatory elements. May recruit transcription factors, or may induce structural changes in chromatin, to thereby modulate embryonic expression of ATP-dependent chaperone cdc-48.1.
Subcellular Localization:
Nucleus.
Sequence:
MSDVAEEKAEFLVIRTYGSESFRKECADLIEKELHKLNATIARVPVGEFVAYAENAVKNETDSEAVGSSSVKRENSANDSPANTNDVDIVSSPVKRGRGRKAKNPSADADVNDTGSSPVKKGRGRPIKNPSADAGSPLVKKGRGRRAQTPAADTDAIDTASSPVKKGRGRPAKNPSADAGSPLVKKGRGRQAKNLAADTDAIDTASSPVKKGRGRPLKKTAAEADVNGLGSPSANRITGCPPSTKVSNQSSPPEPAVNESEEADEPVLKRGRSVKQPKDESESDDEDAEKAPAAIPKKRGRPGKSAIDAFFDGSD
The following text describes a protein:
Function:
May negatively affect PAX8-induced thyroglobulin/TG transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVDVKKFSDIDIYGLLEVDIAATEQEIRKAYRKKALQCHPDKNPDNPKAAQLFQELSKALEILMDVSARAAYDRLLNAKKAAQLRTKQLDSKRQKLKADLEERERQAKEAASGGYKTASSKTPEELFQEEFKRLRKEGSKLIQEEQELMRRQLQEELRMMQTATAPSWDPAQHRIKIRWKADRGDAANGGYTEDVLRKFLSKYGDLNALVMSPRKNGSALVEFRAKDAAEMAVTFEKGRLDNPCTLEWVGEAPTKGKAKATASGGSTITERDYESLVLRQLRQAEERKRLIEQMMKEEAEAEGETTAQ
The following text describes a protein:
Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Sequence:
MWSPDEIASLCYNHFNKLPKRGKPESGREWTLLAAVIQITDCPEQKTVQKQVVSLGTGTKCIGRSAMSMKGDVLNDSHAEVIARRGSVRYLTEQLLKAVRGQSSDVFCAGSEKGKWRLKAGVSFLFFTSQTPCGDASIFPMSGSEAQPCEPVKETTQNEESEPRGLKRPADQETRQKTKHPKINTSDKQPSCRSSGDTEDKAEAENKSCSERSEAEPLDLHRTGAKSVPDGPKDLLQPGLLYHHTGLLRVKPGRGEPTLSLSCSDKLARWCILGFQGALLMHYLQEALYFSAVLVGKSPYSHPALRRALHTRCSHVKDLPSGFSFHDPELLQSSLEFPHNHTHTKSKHTHSQGRISPCGAAISWCAVSQQPLDVTANGYKQGVTKKALGTPQARSLICKVELFHSFLKVVAATEDSELPETLRGKDWKTYWDYKQAAGSYQLAWTQLRLQAFPQWPRGPRQLLLFQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.
Domain:
The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MDAEYMPSVWGVRLRGDELILDYCQKAMDNSTITRQELPCELGLRYGPHPRETMDVYGYGRVPENAPILVFFHGGYWIEGDKDMHAFVAKPFVESGLAVVVAGYPLAPESTLDQIVESARHCMTCVIKMSKQKNSAGIIVSGHSAGAHLAAMVLSSQSWTSRSENLACIKGAVLFSSVLDVKPLLSTSVAKDAAITVDQAEINSPLEVVNLFPRDVFVQLVLAEHDPPPFHRQTKRYMEALRDRGIKCELVVYNDEDHFSFFPRLMDKEDEVTSQIIKNVLRETGTA