lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
Sequence:
MALKKEKEVVASKGEYEPPPLSELQNLLWMNRHSTGHVNEVWPNLYIGDSYTARDKGALFNLGITHIVNAADGRYHVNTGARFYSDMPVLYYGVEADDHPEFDLSLFFYPTARFIRSALSQKGRVFVHCAMGISRSAALVLAFLMICENLTLVDAIKTVRKHRDVCPNSGFLSQLRELDLALMLERKRKAALYKL
The following text describes a protein:
Function:
Plays a role in the autotrophic CO(2) fixation pathway. Activates 3-hydroxypropionate to its CoA ester. Can also activate propionate, and to a lesser extent acrylate, acetate and butyrate.
Sequence:
MFMRYIMVEEQTLKTGSQELEEKADYNMRYYAHLMKLSKEKPAEFWGSLAQDLLDWYEPWKETMRQEDPMTRWFIGGKINASYNAVDRHLNGPRKFKAAVIWESELGERKIVTYQDMFYEVNRWANALRSLGVGKGDRVTIYMPLTPEGIAAMLASARIGAIHSVIFAGFGSQAIADRVEDAKAKVVITADAYPRRGKVVELKKTVDEALNSLGERSPVQHVLVYRRMKTDVNMKEGRDVFFDEVGKYRYVEPERMDSNDPLFILYTSGTTGKPKGIMHSTGGYLTGTAVMLLWSYGLSQENDVLFNTSDIGWIVGHSYITYSPLIMGRTVVIYESAPDYPYPDKWAEIIERYRATTFGTSATALRYFMKYGDEYVKNHDLSSIRIIVTNGEVLNYSPWKWGLEVLGGGKVFMSHQWWQTETGAPNLGYLPGIIYMPMKSGPASGFPLPGNFVEVLDENGNPSAPRVRGYLVMRPPFPPNMMMGMWNDNGERLKKTYFSKFGSLYYPGDFAMVDEDGYIWVLGRADETLKIAAHRIGAGEVESAITSHPSVAEAAVIGVPDSVKGEEVHAFVVLKQGYAPSSELAKDIQSHVRKVMGPIVSPQIHFVDKLPKTRSGKVMRRVIKAVMMGSSAGDLTTIEDEASMDEIKKAVEELKKELKTS
The following text describes a protein:
Function:
Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16).
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Membrane-associated through distinctive regions rich in arginine and aromatic residues.
Sequence:
MKNIGWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYGAPSAPVIDAIRAQADPPGTVTDWIGADSLAERLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIGGAVPAILNFMRQVPEFAELDAPDFRYFITGGAPMPEALIKIYAAKNIEVVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDVAVRGDDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWGEIAAAIVVADQNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKILKTVLREQYSATVPK
The following text describes a protein:
Function:
Involved in larval molting and metamorphosis. May degrade extracellular matrix (ECM) and basement membrane (BM) during the development of organs to allow degeneration and remodeling of tissues.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MESSVATHWLSAFVILCSFITTQSLNNKIHEHMTIDELRNVFHVEHHSRVPEYHLVQLTHHLARRNIPTSHPANSNSADSGKTPHLKTEKVTKGGYKAPSLLNDEMFVEAKKRIEDVDIMGDPNSTVSVDFKVQSSEFGDSESLSDKEHSAESQEDGVHKIDLEAFGRQLKLVLKKQEGLIKKDGLKVWKALKNETQPHGVDYEEMITEDDEEFGDLYQDEENGAALLIRRHPKHGKLVVEGSIGHDLVIRPIPDTMTSPAQDDEMFMDPSSMADMVSIDTGLPIMKRKKEEQDRLQEALNGAQHVIIKRDPAEVDHMSDYAFMEPDHIGKRYRRKRSAEAHNRQKREAPYVIYPEILVIVDYDGYRLHGGDNVQIKRYFVSFWNGVDLRYKLLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRQYANDACNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAEKCRWEDGFIMSDLRHTEKGFRWSPCSVQSFHHFLNGDTATCLYNSPHEDDSLPRVLPGRLLTLDAQCRKDRGTSACFKDERVCAQLFCFDAGSGYCVAYRPAAEGSPCGDGQYCINGQCITEHENIIPDYSQHTPSYVRPETSPFYANITSSRH
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNSQELLAIAVDAIDNKKGEDTISLEMKGISDMTDYFVVTHGNNERQVQAIARAVKEVANEQNIEVKRMEGYNEARWILIDLADVVVHVFHKDERNYYNIEKLYQDAPLESYSQVAY
The following text describes a protein:
Function:
Potent inhibitor of the complement membrane attack complex (MAC) action, which protects self-cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Localizes to the cell surface. Soluble form found in a number of tissues.
Sequence:
MRARRGFILLLLLAVLCSTGVSLRCYNCLDPVSSCKTNSTCSPNLDACLVAVSGKQVYQQCWRFSDCNAKFILSRLEIANVQYRCCQADLCNKSFEDKPNNGAISLLGKTALLVTSVLAAILKPCF
The following text describes a protein:
Function:
With SBE2, is involved in cell wall integrity and polarity processes like bud growth, through the transport of CHS3 and UTR2 to sites of growth.
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Sequence:
MTSIQERGTSAHLHSLKEGEASDRSSEMLPKQRSIIGSHVQRPPSQTTLGRSRAGSNTMNKVSGLDIARRPSENLLSNMNCSDNGNGGNMLNSFVNSALPPPKVNPAQTRRERPASNSSIGTKTTEVFSSTSASSSLGDTSDEGEGSDADKSKINTFPSILMEKATQGRGADGNGMRSASNNTIVEATTDGSKMALQKSMSFDDTAAEKTMNKSRHSYQEQFSSKKSQSSLLNSKQRSRAKSQTCSSTGYNNSSILKTFGISSKISNSSDRIEASSLEFNVPSQKPLNCKPLTPSQKYRLRKEQSEMNLRNTIKRKEKFYDSQEQILELQEGDVDDSLIWNVPMASLSTNSFLASAKPDDMNNLAGKNDLSEYTGGLVNDNSEISYTKQNHRYSNISFASTTSNASLLDFNEMPTSPIPGLNKVTDFQFIQDTTKSLASVYLHSSNRLSRSKLSERTKSSDFLPIELKEAQNQGMEDLILVSENKLDVVSHSRPSWLPPKDRQEKKLHERQINKSMSVASLDQLGKNKDREEKLIRDETNRQKYVLLLDRDITRNSSLQSLSKMVWDTPFSDETRSTIYSEILQSKTRFITKNYIQPFHELQELLTKMGDFPKNKEIEISQLIETSLRRKVSGLHDICPDLMLLLKIKSISSQGIVTGDELLFHHFLVSESFQNLGLNEIWNIVNLVQMTCFNDLCKEKFDAKVLERKGVVAGYLSQNEEFKDEFNTECINSTTWWNILERIDHKLFMWIMDIIVVNNSQSYKNSPINEDEFVNKDWEYYRSKKVVINYKILISFALNVLLNYHFGFTDLRSLCNVNDQRFCIPVFINDEFVDADTVNAVFIKKWAHYYKKF
The following text describes a protein:
Function:
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+).
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPDMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILDEIGADVQERHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCTEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKVSPAALKKTLLDRVKLESPTVSTLAPPSSGKLLTRNPAQGSKKE
The following text describes a protein:
Function:
Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol:disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLFYKPGACSLASHITLRESGKDFTLVSVDLMKKRLENGDDYFAVNPKGQVPALLLDDGTLLTEGVAIMQYLADSVPDRQLLAPVNSISRYKTIEWLNYIATELHKGFTPLFRPDTPEEYKPTVRAQLEKKLQYVNEALKDEHWICGQRFTIADAYLFTVLRWAYAVKLNLEGLEHIAAFMQRMAERPEVQDALSAEGLK
The following text describes a protein:
Function:
Catalyzes the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MRLSFGKIVKLLTTIGILSVFFVLIGMATIGGRFDILIIPSYSSPVLIEQPVCHASGTGRVPIKLNITNEVIFLNSFLSIICKPQDLERLSETYSIATGGIFTPHGCTPSQRVAVILPMRNREEHLRIYLYHMHPILQTHGIMYQIFVAEQIHDESLFNRGKLFNVAVEQILNRGVWDCLILSDIDLLPEDNRVTYTCRDIPQHLGYKMNKFSYKLLYEMFFGGLMAMTPKSYVKVNGFPNHYWGWGGEDDEFGKRIISTTGFHRPNSEFNHFTMIKHRHDEKNWRIGYRKSVVIEEKPLFTHIVADLKYDKIEKDKIKKICRGH
The following text describes a protein:
Function:
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Sequence:
MITNLFIKSFTFSRSLKNFYVLSLLNYFKLKIYNKIYVPTLGVSLKRKRRSYSLNVRKMEITYLSQDLSQKIDNELMSDEVGYTTEQLMELAGLSISQIIFKEYKPCEFKKILICCGPGNNGGDGLVAARHLKQFGYNVVVLYPKVNDKTLFKRLLKLLEHYEINVLMSLRASDLDNYDLIIDSIFGFSFKGEPRKPFDEIIQMINNSNKVVVSVDVPSGINIDSGLSTNSLFINSDMNISLMLPKQGLKNYKKKHYLGGRFIPISIIKKYNLKVPCFSDDNPYVML
The following text describes a protein:
Function:
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MHIATFPALAITALALVLWATVATHSSNTNSCHMSYMKPDMIAMTGFNTTQTPLAHKYSLHLYRELDVDLSREVGGRPVLFVPGNGGSMRQIRSIAGEAAVQYWHDPRRAGADADTWANGSTARPKSALQKLNTFAFGDTESDTEGVRGLGDAVTARDMSGDDRRDAVERPLSNGKLPSQWPDDLPLDFFTVNFQEDLTAFDGTTVIDQAEYLNQAIAYILSLYSSHPNPPTSVIVIGHSMGGIVARTMVTLDSYIHGSINTILTLATPHVLPPVSFDKGIVGLYHNVNEFWKTETVPGGKLEDTLLVSVTGGIRDQMIPAEYSSVDTFLPPTNGFAVATTSIPDVWMSIDHQAMVWCHQLRRVVAETLLVVAGETTEKVSTRLDTFQEYFLSGMERVEKKAQNASESSKLTLDTLVSINTPLTTTSNIIINDHSPNQLVKTKSYFKFPVLKASEINEMSRSFAMPVDKGKSLLVKTNMPLEDLHILVCRTNTGDVDTNGFSFLRYGSKSKGVRVGTDTLVCANVAGEAVAMPSSIKYATGAKIPEEEETGEDNDIPVDSAISSTSLSEYIQLDASSLSGFQYVVVIDNTMSETISSDSYLLAEMALPSDMAVVAAPTWWEVLKVGRFTIELPEKRALLTKISLPHFWSSLVAFSIRLSTSDSFSMEYQCEAKKSMGSEHDVLFAPLLMQYSAQLHEAKFSTNLCGGYEQGTRVAVHGGAPYMPLAEGRDVSGTELYLWTDSSSRSSESLSLTLEIDLWGSLGRFLGFYRVMFAIFPMFVFLCLLMIQLRVWTTTELFVSLSDALDVFVDFQLPWILAGSCAIPFVPHVLVSLLYPQMSQPGQFFLGLNGTHLWFLGPVSLVIATGIVVVLHWLLQILTLWVCQCYYMLGLAPIAPESPFSVRRIVTISFLLLLVFKIVPHQFAFMVAVLVMAMGAGKARVGRLMQSEDKDNKSEPCVVIDRNLINYTHSLLLLLVLLLPINAPTLVVWLHNMANKWHTPLESHHEVSAILPILLLVLTASRGIMIRLPQSKRAIYATFAFLAYFALFVLFHGVVHSYRLHLLTNGLCLCLLYLSL
The following text describes a protein:
Function:
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
Sequence:
MGKTNDWLDFDQLAEEKVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCTLEKA
The following text describes a protein:
Function:
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Sequence:
MYPFDTVTTLSIVMILAAVLTFVGQQFQTACYGRYALHSKFSLKLNPKLSWFVQESPAFFLPVYFILDHLFLNQFGIKSNQVKFTNLFLLSVFALHYFNRSMVYPFKTGSVNKIPIYITLLAFTFCCYNGYLQSKYLMNCHYDSDYMYSFNFIIGMSLFFIGMYLNIKSDSLMSDARKLRGPGTYVIPKGGLYEYVSCANYFSEIIEWVGFAIACWSFPAFAFALYSISYMVPRAKQNHLWYLEHFKPYPKDRRILFPYIW
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
Subcellular Localization:
Nucleus.
Sequence:
MEAELKELFEAAKKAADAAAVDGAGADSSPEEDRCIDALKALKKFPVNYQVLVSTQVGKRLRQLTKHPRKKIQSLAAEMVEIWKNIIVEETLKNKKNGSSDIIKSENGAEASNKKIQKSNSIKIENVSKTESIKIEKHVHSSTQDKKVNILKVEKQEHTVSVTKEENKRPKPNNVMAPPKLTSLVYCKDPVRDKIRELLSEALCKVSGEVEDELRDEVEASDPHRVAVSVESAMFEKWGRSNGAQKFKYRSIMFNIKDPKNPDFRRKVLLGHVKPERILELTPEEMASTERQMENVKIKEKALMECERGAPPKATTDQFRCGRCGKRKCTYYQLQTRSADEPMTTFVTCVNCDNHWKFC
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSDPEPCRIKQEETEELIDVIVKEESEERSEEEEKHHVKTTDRNLKNTAKTKVLERTDAKAFTCTQCGKSFSRKHNLEIHMRIHTGEKPYKCSHCNKGFSLLGNLKIHERIHTGEKPYKCSRCERGFVHSGHLKKHELTHTGDEPYHCTDCGKGFTDLSSLRSHTQTLHDVVMVKEKSEALSEDKKQYVKTEENIDFIMETAAIKSFSCTQCGKCFERRHSLKRHMRIHTGERPYRCSHCEKRFSLLAHLKSHERTHTGEKPHTCAQCGKSFTHLCSLRKHTNTYHSK
The following text describes a protein:
Function:
Transcription activator that acts as a flowering master switch in both long and short days, independently of the circadian clock. Promotes flowering upstream of HD1 by up-regulating FTL1, FTL4, FTL5, FTL6, EHD1, HD3A and RFT1. Seems to repress FTL11 expression. May recognize the consensus motif 5'-TTTGTCGTAAT-3' in target gene promoters.
Sequence:
MASASSSSSPLLGIKDEELQHEQKQQQQSSSATLPATLKKKRNQPGNPTADPEVEVIALSPETLLATNRFVCEVCNKGFQREQNLQLHRRGHNLPWKLRLRSGEEEGRRRRRVYLCPEPTCAHHHPSRALGDLTGVKKHFCRKHGEKRWKCNKCSKRYAVRSDLKAHSKTCGNCEYRCECGTLFSRRDSFITHRAFCDALAQESSRLPAAGLDLHGNNTMALSVSQMNARLTSLRDQGGCGTPVEHLVTAAHPSLFRPPQLPPPAAFYLGNGSNQGFDEEHQPDLSLLRGKRFDGLMQLPDPQGNTMAAADLFNLSFFSTSSRSTSSIRNSNNGGDQYNQMLLASDFSDANGRSELTSLFSGNLVSDHVAGGLTSLYNQNESNLLPRMSATALLQKAAQMGSMTNIGHSLLRGFGNSSSSSPRPPNTGGGNSGDGLQARTENETHLRNLMNSLANGRTGLIGGPQQETREFGSDAKLNLWGTDQLTRDFLGVGGMVMRSISGGTSRQEQNHGIDMSESNPR
The following text describes a protein:
Function:
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEDPNPEENMKQQDSPKERSPQSPGGNICHLGAPKCTRCLITFADSKFQERHMKREHPADFVAQKLQGVLFICFTCARSFPSSKALITHQRSHGPAAKPTLPVATTTAQPTFPCPDCGKTFGQAVSLRRHRQMHEVRAPPGTFACTECGQDFAQEAGLHQHYIRHARGEL
The following text describes a protein:
Function:
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MQCNADFALGDILILTNDDDEPVRVGDITVFRIEGREIPIVHRIIKIYENYANNTKVLTKGDNNQGYGPATQVRWLQENRHHFAPTQTGVNRQMRFPVNASNYHIPPKRMRMD
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase.
Subcellular Localization:
Nucleus.
Sequence:
MAPPGGKAAVVLCVDVGFAMGTSAPGDQSPFERAKKVMSMFVQRQVFAESKDEIALVLFGTEGTRNALAGDDQYQNITVHRHLMLADFDLLEDIQSIVGPGSERADFLDALIVCMDLLQKETIGKKFDKRHIEVFTDLSSPFSHDQVEVIISNLKKYGISLQFFLPFSVGREEGGAGDPGDHGSHPPKGLTEQQKEGLDMVRKTMMTLEGEDGLDEVYSFSESLCQLSVFKKLQRRPMPWPCQLTIGSHLSIRIVAYKAILEEKVKKTWTVVDARTGKKEDLRRETVYCLNNDDETEVQRDDILQGFRYGSDIVPFSKVDEEQMKYKTEGKCFSVLGFCRAAQVQRKFYMGNQVLKVFAAKDDEAAAVALSAVIHALDQLDAVAVVRYAYDRRSNPQVGVAFPFVKEAYECLIYVQLPYMEDLRQYMFSSLKNKKTCSPSEAQLSAVDALIDSMSLVHRDEEGDVVEDTFPTTKIPNPQFQRLFQCLLHKALHPSDPLPPIEPHLLSMLGPPAEVTSRSQAPLARVKALFPLKEVLKRKDPKTAQDIFQDNHQEEPGTKKAKMEEGSAFSVCNLAEGSVTSVGSVNPAENFRFLVRQKNANFKEVGQQLASRIHQFLEAKGLQYYLKSLDCIRTFRQEAVQLSGEQHFNDFLRALRDQVEERKLNDFWESVTEDGITLITKDEAPGSSVTTEEAQEFLAPKEKAAVAEAAVGEDGGDVDDLLDMM
The following text describes a protein:
Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATAASSITLTVLMGVLLVGVVAVLARLEDWRSYTPLSDVGGGLGERTGYTHEEKPGGIIRWFTTVDHKDIGILYGVYGTIAFAWGGVSVLLMRTELATSSETLISPSLYNGLLTSHGITMLFLFGTPMIAAFGNYFIPLLIDADDMAFPRINAIAFWLLPPGAILIWSGFLIPGIATAQTSWTMYTPLSLQMSSPAVDMMMLGLHLTGVSATMGAINFIATIFTERGEDVGWPDLDIFSWTMLTQSGLILFAFPLFGSALIMLLLDRNFGTTFFTVAGGDPIFWQHLFWFFGHPEVYVLVLPPMGIVSLILPKFSGRKLFGFKFVVYSTLAIGVLSFGVWAHHMFTTGIDPRIRSSFMAVSLAISIPSAVKVFNWITTMWNGKLRLTAPMLFCIGFVQNFIIGGVTGVFLAVIPIDLILHDTYYVVGHFHFIVYGAIGFALFAASYYWFPMVTGRMYQKRLAHAHFWTALVGSNATFLAMLWLGYGGMPRRYATYIPQFATAHRLATVGAFLIGVSTLIWLFNMATSWREGPRVDSTDPWDLEETDQFTNDWAWFRAKEETTVLPDGGDEAQSEADAVTDGGQPAADSDTES
The following text describes a protein:
Function:
Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.
Subcellular Localization:
Cell membrane.
Sequence:
MWLNFAYAAALTAVSPLVLHRMIRHGRYRRGIGQKLLGLSSDRAAEIRGDAERTIWLHAVSVGEVNLLPELDRRLKKLHPEIALAISSSTDTGYDLARKHFGDERVFFCPFDFTWTVRRTLKNLRCEQLVLAELELWPNLIRCAKEANCSVRVINGRLGQTSAARYQQFAKLLRSTFARLDAVGCQDTSAAERFVACGVPSENVTVTGSLKFDNAPRTRDTTEVNERINWSGMDPWHRVWCFGSTQAGEEAMALRVYQRLRSKHPELRLILVPRHVERFEEVASLIQSQGLSAVRRSSNDSQYADQWESEEVILIDTIGELRHWWGVGQIATVGGSFGDRGGQNMLEPAGYGCAVSFGPNTKNFDTIAKQLIAAEAAVRVANETELEQFVSRCLTDIPAADSLGQSARDLVNQHRGAYQKTLEMLIPMQVQSRQKAA
The following text describes a protein:
Function:
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Subcellular Localization:
Endomembrane system. Note=Cytoplasmic, membrane-bound.
Sequence:
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MSSASLTAIVREKSGKKCRKEGFAPGIIYGAEMKESIKVKFEVPSLLRYLNKAGINSRLWLNIGNKKEYVLIKEIQKEPTTGEILNIDMQAVSHDEVIKNSIPVKFEGKEQLEHKGFLLEEFTPYIEVAGKVGILPEIIVVSVGENEPGDNIKVSDIKLDEDIKLYTDPEELLATVSYNGKGTVEETVS
The following text describes a protein:
Function:
Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Sequence:
MDMPKPPFVIYKGKVEEEFARLHKDGKSLLKAESKFVQFLGLQELTDRACDHVELANPTKNTIIFNIRTPTSPCFFVKPHVGMIDPGGKATLYFTFKGRCHRVPSDYCWIYSIYQLVVDEKTTAFIKEDEFSSQNLRSAWIKHGRKQVNNILHLASSFKAGKPKFECRDGHRKFLERKIYLNDLGDVENSGKSKTENTTDITPANMKKGKLNKAASSDTMDDLPKTAD
The following text describes a protein:
Function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Sequence:
MSTVLAQKLWCTLWSAGSLGRFAQHMSNAAHQVSCIGSEEQRVYEEPHVIFQNWLMAAQKEAPQVRPRLACMATVDKSGEPVTRLTSIEEVNSHGITFFTTLGSRQAGEISANPHVSLHFNWAPLMRSVRIAGSAHQLTEEQVRDQFRRFPRHVQMSITHGPRYAAAEWQSRSGFFARIGQRLNTWLGKQPEEIPMPHNWGGYILTPSLYEFGMLSGEKAGRTRVRFRRCLEMPRGTRVGHVQAERQDWVYDSCDEN
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MRTLLSFLLLALASAVAAISTSGNRLLVVLDDVADKANYSKFFADLEEREFKITYETPKSDSLTLFSLGERTYDHVLFLPVRTKGLGPNLTPKTLHDFVNAKGNILLALSANTTTPTSLIALLSELDITLPTDRNSLVVDHFNYDITSATDKHDVLLLPPPKPTRAGIKDFFSEGAGTKLIAFPRGVGAVLGNGQLLNPILRAPRTAYSYNPKEQVEAVNGDDLFAAGQQLSLVSTMQARNNARVTVVGSAEMLQDKWFDASVTKLDGQPVVQTFNREFAKRVSGWTFQEIGVLKVNWVEHHLEEEGAPNDSNPEMYRVKNNVSYTISLSEFAWDHWIGFNVPEHDEIQLEFSMLSPFHRLNLKEESHRLAAVHYHTVFTTPDQHGIFNFMVNYKRPFLSHIEEKNTVPVRHMAHNEWPRSYVISGAWPWIAGLGSTVVGFLGFVALWMYSAPVDAGKKVTVKKTQ
The following text describes a protein:
Function:
Catalyzes the first step in the biosynthesis of branched-chain amino acids.
Miscellaneous:
MISCELLANEOUS: E.coli contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH. In strain K12 only the Val-inhibitable ilvBN and ilvIH are expressed; ilvGM has a frameshift that disturbs the ilvG reading frame. IlvG (this protein) is Val-resistant and is expressed in K12 strains having what used to be referred to as ilv0 mutations. The ilv02096 mutation (shown here, an insertion of 2 bp, PubMed:7015336) causes a frameshift which restores the open reading frame, permitting the expression of this isozyme. The inactive N-terminal pseudogene fragment is found here (AC P0DP89).
Sequence:
MNGAQWVVHALRAQGVNTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLITGLADALLDSIPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLEELPRIMAEAFDVACSGRPGPVLVDIPKDIQLASGDLEPWFTTVENEVTFPHAEVEQARQMLAKAQKPMLYVGGGVGMAQAVPALREFLAATKMPATCTLKGLGAVEADYPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPHASVIHMDIDPAEMNKLRQAHVALQGDLNALLPALQQPLNQYDWQQHCAQLRDEHSWRYDHPGDAIYAPLLLKQLSDRKPADCVVTTDVGQHQMWAAQHIAHTRPENFITSSGLGTMGFGLPAAVGAQVARPNDTVVCISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTDNPDFLMLASAFGIHGQHITRKDQVEAALDTMLNSDGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS
The following text describes a protein:
Function:
May have a role in glucose regulation.
Miscellaneous:
MISCELLANEOUS: Present with 2810 molecules/cell in log phase SD medium.
Sequence:
MLSDCLLNNFRITAQIGSGAYGLVFHVVDILTSREYAVKTVFKSSSMDEFYNKNGLNNNSQVARTTLLQTQLYHFFKSFQKKLFLPSVDLDSILQLTENELNRLPHYREIAFQLRVQSHGNIVKIHQVLESSIATFIVMDYYDRDLFTSIVDDKHFVNHGILIKKVFLQLCSALDHCHRLGIYHCDIKPENVLLDRNDNAYLCDFGLSTKSKYLAPNVCVGSSYYMAPERILYCLNTTTNGIHVDECCSSLPTDTGDIWSLGIILINLTCIRNPWLKAHQKEDNTFQHFANDNNVLKKILPISDELFTVLTKILQLNPYTRIDMKTLMSEVSSLTSFTREGPLSQVPILSSEVYMTHIIRNENLFLSDLSHFSADQEQQQQQQQQQQQVQEQEQEQKQEQIQNQEQAQQQQEEEDAEPESDIPSTYNSDGSMEKYEYTNNHNNSTFLTSSMDSTPYQSDIDDVSASKDCKFQQDTLRNRLLCLQMNFSTLTDGPNEKWLPDY
The following text describes a protein:
Function:
Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
Subcellular Localization:
Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus. Mitochondrion.
Sequence:
APDVISHLPELRLVLLGRAGAGKSTAGNTILGREEFQTDRITTLSTKSEGVVAGRQITLVDTPGWDGTLRLDTPKKVKQEIELSASLCFLGPHALLLVIPLDSPTEKAAAKELSEIFYQNAWWHTMLLFTCKESLEGRTIEELIESAGEELHQLLKKCGDRYHVLCTKNRTNPMQIEKLLEKSEKLATENNGVYIKNEILTEQGEKEKHERRRNPKTRSEVDSPEVERPQKQKPREEELVMKEGNRNRQVMNLNLPNPKDKVELGKEPEGKPNSDSTPKALVQPNGFRSHIICFQDKYAYLWEVPQLISTAPNKNGDLEASDLPGLRLVLLGLTGSGKSGVGNTILGQEEFTTSSSAGKKECEIRKGQVFGRQVAVINMPDWFSTEFSLDEIQSQIESYVSLSEPGSYALLLVVPLDQPVGNGRRTGDAIQEVFGEQSVRFTLVLFTHGDVLKEKMSERMLECKDREVTTLQRAGQERETNQRERQDSLQTQDTERTHAVKKSSKLINTYQ