lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof. During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage. The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres. Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion. Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif. Probably represses expression of eff-1 to prevent fusion of seam cells with the hypodermal syncytium. Involved in regulating expression of elt-3, a probable downstream target in hypodermal development pathways, in dorsal and ventral hypodermal cells. During postembryonic development, has a role in sperm development. Specifically, binds the bipartite consensus sequence 5'-AGATCTx(8)GATAA-3' found in genes with sperm-specific expression. Furthermore, regulates timing of developmental steps, possibly in parallel with daf-12, by controlling the expression of the let-7 family of miRNAs which in turn determines the transcription of heterochronic genes such as lin-41.
Subcellular Localization:
Nucleus. Perikaryon. Cell projection, axon. Note=Expressed in pachytene nuclei during the first stage of meiosis.
Domain:
Both zinc fingers are required for DNA binding in vitro.
Sequence:
MDYEGKPVEFTLGTSSGGASLAPTSSTTAASIAPFSYNTSATNYYNTTPSSYPMFLNYQYAGGTTVTTDMDAFSGMDMSMNNGVFGTQNNPSYFYPTTQLNTYGYDTLAAATTASGITVNNNQLNVNIVQGNGTIVPQPITQNIISTVSNVQSSVPINNSQPLTPTGLAGCSTSSGSSSASSSSANSTSTPKNTISKANRSSGGANNSQFSTEDRECVNCGVHNTPLWRRDGSGNYLCNACGLYFKMNHHARPLVKPKKRQQNAQKRTGIECVNCRTNTTTLWRRNGEGHPVCNACGLYFKLHKVERPITMKKDGIQTRNRKLSAKGSRRMKKENGGTPTSMGMPTTSSSISSGIELDQSGVWGMKNTQPMLMTPTAYAFPASNFYFNSIEDQLEYKTCPPMMVDFGGQMKNLNLN
The following text describes a protein:
Function:
In association with P2 and trimeric P5, forms the spike complexes located at the 5-fold vertices of the capsid. Essential for viral infectivity.
Subcellular Localization:
Virion.
Sequence:
MNVNNPNQMTVTPVYNGCDSGEGPQSVRGYFDAVAGENVKYDLTYLADTQGFTGVQCIYIDNAENDGAFEIDVEETGQRIKCPAGKQGYFPLLVPGRAKFVARHLGSGKKSVPLFFLNFTIAQGVW
The following text describes a protein:
Function:
Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MEEISDLSNKKLKKLAKFSPQESQVITTLILDDNELQRLDNIDSLFRLQKLSAVRNQLLRMYGVCRLHSLHTLNLAHNGILTIEGLKDLVNLKWLCLAGNSIKTIEHLNTNTNLEHLDLSENNITHINDLAFLKDLKELFLHNNKINHLRQSDRFLPTSLITLTLANNNIEDLNEISQLVHLVNLQNISIANNPCVNFGNTNIGFDYRPFVINWCLNIKTIDGYVVDAIESLRAEWLYSQGRGRHFRVGDQKDLVQYLASVCPLTGEALETEEDRKLRLILSKAQHHQQQLREQSTGSSNPSPLTRKKLHGAKHSPRLNSARATAKLRSPDRMSSSCYGNANVMENSNIMSQSLDPTILRQSVTPSKTPSEKRLDDEPVNSPLQALSKMVPVPESLMSPDYRPAPILGKTVLTSVNNKKLPQAVRSPKLGRNLHNKNKPQANDGGKSSSPSPARARKAMNHENNANKTSILRKSLSSDDESEVFVSKLQKIQIRAEEKRIMNQKDAEILNNCNSEDRVEQAAVFIQKMWRGYFTRNRNKEVQEIFRTLQAQRANQYIQQLTDDMETTKAALESERKIQMLQTEAISALWKQMSALQPNSGQSSTANMTNLSTDNVEVVKELAKTCTVLQNQIQQLQSSMQDIVKVMTVFSQTTSINPNGIATQTEIVAVHTPQGEAAKVFPFHKQTRPSSLPLPINQRKKDNVNTELQQYADNLVDGVIKTVSETRADCVGSDLTEITVTDTAKMDETQVSN
The following text describes a protein:
Function:
Plays an essential role for patterning the left-right axis. Requires solely on the left side, downstream of the leftward flow, but upstream of dand5, a nodal inhibitor involved in left-right patterning.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSFLLCIGILLLPWFPCVCGKCIFDQIQRSVNVVSPPTAQYASAYRFKTQRSKRHIMPMDNLQPIRIKIWIPSESPALSDWEREKLMSAVGEAVSEVSSLLSVKRVKDRLLLNRDVNKYCKFIWRNSSTLNHMKCGRAHENYRFESCLGVIIPDEHLDGCSVYPNPEHPVPTVLRPRGPGVPDADFLLYVFTHNTEKCRAESSVLAYTAHCQTGSDGRPLAGTMVICRETLKKERYTYQHFVKVTTVIHELFHVLGFSKELLSNWKDFGVDCWSHGQVTSTDQTGQVRLYSPTVIRAMQKHFNSTHTDLGAPLENKDAALDGLSSHWEARVLQGSIMAASLVEASLVRIDAITLAALQDTGWYSVNHSRAQSLVWGEGEGSDFGSVSACHNSSAFFCTGSGLGCHFLHLNKGECVTDQYLDGCHIFKPLANASECWIEDNARSGMNEGGGEIFGSDSRCFISNITRLNNVTAYTPVSGHCYRHRCTGINKYHIQVKDSDWMDCPAGTSIEVSGYQGFIFCPENRLCKYSDLAPPTSTQRTESLFSDTTAQSDLGMMEKDAAVQPSFTSLFLVSEAKISLAAVLSLMAVFALLSAAVLLYRKNLSVRVHAASYRTPLPHILYRN
The following text describes a protein:
Function:
Probable RNA-binding protein that plays a role in meiosis and vegetative growth.
Sequence:
MDIPQDVAGAWGIPSGMGRHRHLPSDATLFSASLPVLPHGKLQSSDSRDGFPFIDDAAASRPVHESVDDIESHSIGNMLPDEDDLLTGMMDDLDLTELPPDSADDYDLFGSGGGMELDADFRDGLSMNGGPPRLSISSAVPQFNVQNGAGTVAGEHPYGEHPSRTLFVRNINSNVEDSELKTLFEQYGDIRTLYTTCKHRGFVMISYYDIRAARMAMRSLQNKPLRRRKLDIHFSIPKDNPSEKDMNQGTLVVFNLDPSITNDDLHGIFGAHGEIKEIRETPHKRHHKFVEFYDVRAAEAALKALNRCEIAGKRIKVEPSRPGGARRSLMLQLNQELENDDLHYLPLLGSPMANSPPSNWLQMNSPVEGSPLQSVLSRSPVFGVSPTRNSHLSGLASALNSQGPSSKLAPIGRSPVASNVFQQSSHLFQEPKPDNKYTGNLSPSGPLISNGGGIETLSGSEFLWGSPNTRSEPSNSSVWSTSSTGVPFSSARVDRSVPFLHQTQNRSHHPHHHHHLHVGSAPSNVPLEKHFGFFPESSKDTMFMNSSGMGGGLNGVSFPMMSSPRFSPMFLSSGLNPGRFPAGVDGLYENGRPRRVENSSSQVESRKQFQLDLEKIMNGDDSRTTLMIKNIPNKYTSKMLLAAIDEKNQGTYNFLYLPIDFKNKCNVGYAFINMLSPDLIIPFYEAFNGKKWEKFNSEKVASLAYARIQGKTALIAHFQNSSLMNEDMRCRPIIFDTPNSSDSVEQVIVKETKNGDLFDSEVNDDEDDGREKS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
TEQGSWENGLSYECRSLLFKALHNLIQRCLLSRGFTRLGKWFLQPCDTSEKDRGGPQLTFAFHFFVHGDSTVCASVDVRQHPAIYRLSRHHLLQTQAGTHTPTKVILGPFGLAGTLTGQGYKETDAATQTLLSEWHQFFPLPPHASAVPQRGDATPPGGDEELLPCAVEALVGGVKLRYPSAYVFVVETDEPAGRQETPPVAPNPATPVPNPGAPLCGPHLPRGGPPGYPGGMKLPPGLTGVLTPPTSPRDPGYFHHGGGAHLRGPGQVAAAGGPGPPGRPACPPAPPPSSIVPADGPPVAVVAHKTKGAAWQDGLLSRGPCEDEPGGWDFVEPCGQTHCFCYRCHRNKPRPTTPGPAAVCAASSGTPLCPSGPPQGSSGAQAAPSPSAKKSSSDKGSGRPRGPPATPFHRRSPVPGGAAPFVDYESIALPPAAGKLPQPQGGAGSLLPQLHTQQGPPPSVGSCSHPGTPLLLSEGGGPASQASQADPAMPTLSPHPPPREEGPAAPRPSPAPQDAGGATGASPAPPQGDAAKDRPPGEQLLSPSSLLDVKPPLEAPPSCSPGGGSHQWGGPGSCSSAAATPAAPSGLPAPSSASSVGPGEDGVKRPCLPTIAHEALVEAETPPMGSRLLYDYSSVYPPPWEVPPCKRPHLGAAPRRPNAGDVCGPYSSQPYRRVEGEPPCEPQQSAPPAPGGSRDPYEFHEDCDDDAAGPASTAARAALQGTPGQPALLVPKEEDKEGVPMDTSGQELGSAATPNSGTGGSATPVPDCGALLPGSKEGSKEGAPRGGSLAGSATPGSTGDLPGVGSPPTPRHPGFTRVEDLKVTDCDLENIFDTSSSDESSDDPFQAPSTPSSTKPAGASDEPPGKSKNSTTAGILGAAELTRMFPTPPSLEHNAAPSPSGPVGVPDLLMGDGSDPFFTKGMDAYCNYGSPGFEAVRDWSYVFKPPMVHQFLSSPRYAPLGQLPSAALPPLPALECAYKPSWQRDGGAGSQAPQGSPAGAPLQGQRHLPHYHPAVHHPPTPAGPSPVGPMSSQQHMMPQEAFLRMGGHVMAGAGLHPSLLDRHPSHHQPGMDERVPYPGMLDHPSQLGPMGGPPMMGGYELGPYAANGPLGPLGAAAYMGPHGGRHLALPHQGMHPLHGQQQALGPAEGGGAVLPEADSLLVNLLLSDSLLELFRDHNFSSCTLCVCNMNIKGADVGVYLPASLVPTASEEPQYKCTCGFSAVVNRHHSHRTGLFYQDEQDVTGIPYEATPGPHRAQVGPGGGPQLPHRGPGGPLANGSLQLPKVHEEGLLEYVQSQCLGMALSPCSVLHKTLQLGAERQHDLGASPVVTGLLQVPPQLRGQGQSSLLQRQNLHHRQGPLALLPALDGCEVTLGALEAAASRPLDEPLGSPCLHRWPYLHCPCPPSSLVSVGLLRGLQPLLQDAVHKKRNQGLWEVTYRVAGPLTWRQFHRLAGRGTEDQCEPQPIPSLLVGYDRDWLALSPFALKYWDLSATYQALNLGRHCPLSRGGLREGLLRVSAQGPPPETPGGTNAEDDWFTGLGEGPLGTRLRLFARACRMQLGPHLASQSLDRGLLEGPPGAPKSGDSKAPLASPRPPPTPEGAGSAGQQEGSSTRDGGTTPRPQADSEAHNFVRWTLTIGVSVSAPRAESSQDACGALSATAPGNPSQGTSLGAPAGIGASAGPTSTGGASSTGGAASAPGGAGLGVSEEGEEEQQPPALVVYLVEPFTLGSSDPEVLRLATVGLHRCFAQLLDCLPEPLQSNTHAQILSLDSILGAGGRSAEGFRRQEQLRALSLSVFYQCARLLVHQSSVKSLTGFGPAAAQDDFLKARTAFLQTRRKKACARRLGLHKLLDWLLGVAACGPRGAGAITQPWRLVVGRLGRPDGALRLFHDRYTPDERFSSACHSCDLSTPQDASATHILVFPTSATTQSSQATFQQDHMDPLSTTLGDDDEIFKSLTEDIAVGNDFNDILNWTDSPEAPCSPTRRSSPPGSPGAMMGGGPGGRQSPFQHGGALRGPGSGGADAQEEPMQLLQQPLALGYYVSTAPTGSLPRWFWASCPHLRESCPVFLKSALLLHCPTVHQNHDDLLHGNPHLRNYHPLDSTLTTDVLRYVLEGYNTLSWLSLDPHSHDRQSCLPLHMQNLMKLYHAVEALL
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MRMLLGLPQLWILPLLVVVLFQCSFALVIDYSYVGARGPRHWGDLKSDWKECSDGKAQSPIAIRSKHAELNSSLPGLRAHYQSSVCSIASSQYIFKVFIAGAHCTLPLNRATYTLTDFHFHIPSEHTVDGTRFPLELHLVHKVAPNSSQITVVSKLFKLGRSDPLLDQILKLKEGNATINLSNYINLHGGYYRYLGSLTTPPCSEGILWTILKKTGTISSSQIKRVIALLQGKNARPLQKINKRAIYKHSS
The following text describes a protein:
Function:
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQRGSSSKSGKLKGDDLQTIKKELTQIKQKVDSLLESLEKIEKEQSKQGVEMKNDKSEEEQSSSSLKKDETNVKMESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKEAEEGEDDRDSANGEDDS
The following text describes a protein:
Function:
DNA-binding protein that recognizes oligo(A).oligo(T) tracts (A.T DNA). Can bind to any 11 bp sequence in which 10 bases conform to an uninterrupted oligo(A).oligo(T) tract.
Miscellaneous:
MISCELLANEOUS: Present with 4700 molecules/cell in log phase SD medium.
Sequence:
MAKTLAQGRKPGSGRKPGKGKTLREGRKPGSGRRRRQDTGGKETDGSQQDQESRLISSRDMEAVDALRELTHSPSSHSAHNSSAAPPPHAAAASTSLPPSLDYTHQSFMDQQQQQQQQQQQQLLQQQRVDVVPPKPFITHKILLSSTGNSGGHVNSNYNADHSINHNSNHNLNSNVNVNMNFTINGSNQDPSSSFLMGPYNYLQRPFIVKPYLDLSTSTAASNQPRTQPSPAAHITKNSDSTEKNATI
The following text describes a protein:
Function:
Probably plays a role in host phagosome maturation arrest.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSFVVMPPEINSLLIYTGAGPGPLLAAAAAWDELAAELGSAAAAFGSVTSGLVGGIWQGPSSVAMAAAAAPYAGWLSAAAASAESAAGQARAVVGVFEAALAETVDPFVIAANRSRLVSLALSNLFGQNTPAIAAAEFDYELMWAQDVAAMLGYHTGASAAAEALAPFGSPLASLAAAAEPAKSLAVNLGLANVGLFNAGSGNVGSYNVGAGNVGSYNVGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGEANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGVLWRGDYQGLLGFSSGANVLPVIPLSLDINGGVGAITIEPIHILPDIPININETLYLGPLVVPPINVPAISLGVGIPNISIGPIKINPITLWPAQNFNQTITLAWPVSSITIPQIQQVALSPSPIPTTLIGPIHINTGFSIPVTFSYSTPALTLFPVGLSIPTGGPLTLTLGVTAGTEAFTIPGFSIPEQPLPLAINVIGHINALSTPAITIDNIPLNLHAIGGVGPVDIVGGNVPASPGFGNSTTAPSSGFFNTGAGGVSGFGNVGAHTSGWFNQSTQAMQVLPGTVSGYFNSGTLMSGIGNVGTQLSGMLSGGALGGNNFGLGNIGFDNVGFGNAGSSNFGLANMGIGNIGLANTGNGNIGIGLSGDNLTGFGGFNSGSENVGLFNSGTGNVGFFNSGTGNLGVFNSGSHNTGFFLTGNNINVLAPFTPGTLFTISEIPIDLQVIGGIGPIHVQPIDIPAFDIQITGGFIGIREFTLPEITIPAIPIHVTGTVGLEGFHVNPAFVLFGQTAMAEITADPVVLPDPFITIDHYGPPLGPPGAKFPSGSFYLSISDLQINGPIIGSYGGPGTIPGPFGATFNLSTSSLALFPAGLTVPDQTPVTVNLTGGLDSITLFPGGLAFPENPVVSLTNFSVGTGGFTVFPQGFTVDRIPVDLHTTLSIGPFPFRWDYIPPTPANGPIPAVPGGFGLTSGLFPFHFTLNGGIGPISIPTTTVVDALNPLLTVTGNLEVGPFTVPDIPIPAINFGLDGNVNVSFNAPATTLLSGLGITGSIDISGIQITNIQTQPAQLFMSVGQTLFLFDFRDGIELNPIVIPGSSIPITMAGLSIPLPTVSESIPLNFSFGSPASTVKSMILHEILPIDVSINLEDAVFIPATVLPAIPLNVDVTIPVGPINIPIITEPGSGNSTTTTSDPFSGLAVPGLGVGLLGLFDGSIANNLISGFNSAVGIVGPNVGLSNLGGGNVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGFGNVGLANSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGDYQGLLGFSYRPAVLPQTPFLDLTLTGGLGSVVIPAIDIPAIRPEFSANVAIDSFTVPSIPIPQIDLAATTVSVGLGPITVPHLDIPRVPVTLNYLFGSQPGGPLKIGPITGLFNTPIGLTPLALSQIVIGASSSQGTITAFLANLPFSTPVVTIDEIPLLASITGHSEPVDIFPGGLTIPAMNPLSINLSGGTGAVTIPAITIGEIPFDLVAHSTLGPVHILIDLPAVPGFGNTTGAPSSGFFNSGAGGVSGFGNVGAMVSGGWNQAPSALLGGGSGVFNAGTLHSGVLNFGSGMSGLFNTSVLGLGAPALVSGLGSVGQQLSGLLASGTALHQGLVLNFGLADVGLGNVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGDYQGLLGFSYTSTIIPEFTVANIHASGGAGPIIVPSIQFPAIPLDLSATGHIGGFTIPPVSISPITVRIDPVFDLGPITVQDITIPALGLDPATGVTVGPIFSSGSIIDPFSLTLLGFINVNVPAIQTAPSEILPFTVLLSSLGVTHLTPEITIPGFHIPVDPIHVELPLSVTIGPFVSPEITIPQLPLGLALSGATPAFAFPLEITIDRIPVVLDVNALLGPINAGLVIPPVPGFGNTTAVPSSGFFNIGGGGGLSGFHNLGAGMSGVLNAISDPLLGSASGFANFGTQLSGILNRGADISGVYNTGALGLITSALVSGFGNVGQQLAGLIYTGTGP
The following text describes a protein:
Function:
Involved in cell division and chromosome segregation (By similarity). Involved in sporulation. May coordinate the cessation of aerial hyphae growth and subsequent chromosome segregation and/or septation. Required for expression of the ParB partioning protein during sporogenesis. Activates its own transcription and represses WhiB. Binds with low affinity to its own promoter and to the Parp2 sporulation-specific promoter. Also binds directly to the RNA polymerase sigma factor WhiG, leading to inhibition of WhiG-dependent transcription in a dose-dependent manner.
Domain:
DNA binding is primarily driven by the H-T-H domain, but requires full-length protein for maximum affinity.
Sequence:
MTAAVKSEISQLPVTRTCCRKAEVSAVLRFAGGLHLVSGRIVIEAELDTGNAARRLKRDILEIFGHSSELIVMAPGGLRRGSRFVVRVVAGGDQLARQTGLVDGRGRPIRGLPPQVVSGATCDAEAAWRGAFLAHGSLTEPGRSSSLEVTCPGPEAALALVGAARRLSIPAKAREVRGVDRVVVRDGDAIGALLTRLGAHDSVLAWEERRLRREVRATANRLANFDDANLRRSARAAVAAGARVQRALEILADDVPEHLAAAGRLRMEHKQASLEELGALADPPLTKDAVAGRIRRLLAMADKRASDLGIAGTDANLGEEELADNLVG
The following text describes a protein:
Function:
Catalyzes the non-oxidative deamination of L-phenylalanine to form trans-cinnamic acid and a free ammonium ion (By similarity). Facilitates the commitment step in phenylpropanoid pathways that produce secondary metabolites such as lignins, coumarins and flavonoids (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAPTADVLPPVEASTRPGLLVQPSDTKLRKASSFRTEQVVIDGYNLKIQGLVASARYGHVPVLDPSAETRKRIDDSVQSLIAKLDRGESIYGINTGFGGSADSRTANTRALQLALLQMQQCGVLPVPSTFPTGEPSSAPFALPLTDTESSLIMPEAWVRGAIVVRLSSLMRGHSGVRWEVLDKMQKLFLQNNVTPVVPVRSSISASGDLSPLSYVAGALAGQRGIYCFVTDGRGQRVKVTADEACRMHKITPVQYEPKEALGLLNGTAFSASVAGLATYEAENLASLTQLTTAMAVEALKGTDASFAPFIHEIARPHPGQIKSAKFIRALLSGSRLAEHLENEKHVLFSEDNGTLRQDRYTLRTASQWVGPGLEDIENAKRSVDIEINSTTDNPMIDPYDGDGRIHHGGNFQAMAMTNAVEKIRLALCAMGKMTFQQMTELVNPAMNRGLPANLASTPDLSLNFHAKGIDIALASVTSELMFLGNPVSTHVQSAEMANQAINSLALISGRQTLQAIECLSMIQAWSLYLLCQALDIRALQYKVAEQLPTLILASLHSHFGEWMDETKQQEIAAQVLKSMSKRLDETSSKDLRDRLVETYQDASSVLVRYFSELPSGGGADPLRNIVKWRATGVADTEKIYRQVTIEFLDNPYACHASHLLGKTKRAYEFVRKTLGVPMHGKENLNEFKGEFEQWNTTGGYVSVIYASIRDGELYNMLSELERDL
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MLKNSLGRIPSKRRLIDARVTRPDGAARLICRRNSHISEEGDINSGRYHRLATANSSSNQQPPIRSNSHQISSTSSDPPLPAIGLELHVQLASDSKLFSSANPPTADQDSNTNLALFDAATPGTQPVLSSDCLRLALIASLALECKINRKTSFDRKHYFYPDLPAGYQITQHYSPIASDGKVLITPEDGADRSFEVRITQLQLEQDTGKSTIDPLYPGQTLIDLNRSGVALIEIVTGPDLRTAKEASIFVRKLQSILRFAGVTKGNMEQGSLRCDLNVSISQSENSTIQGSRCEVKNVNGFGHIEHAIDFEISRQRALVAEGQRVEMETRGFDVARRQTFRLRDKESQTDYRYLPDPDLPPIIFPPAILERLRNMVPELPHPMARRLQESYGLSRTIAEVLMMIGSERIDHLADVGCGVRYFEAAMDASSVEVEGKTMANWIVHELLGLLAKFELRFVDCPVCPKEFGELVGRVSNGTLLRPIAREILSEAIKTPTISLKERLEKNQMKSQNNKEEGRDLESPVIKKLVQEIMSEMPKEVELIRNGRPQIIAKLVGEGMRRSQKSVDPRLLRTAFEEELLPHSSAQSS
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Sequence:
MEASWLENRWARPLHLALVFCLALVLMQAVKLYLRRQRLLRDLRPFPGPTAHWLLGHQKFLQEDNMEKLDEIVKEYPCAFPCWVGPFQAFFYIYDPDYAKIFLSRTDPKTQYLHQLMTPFLGRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQCTEKIIQDRKKTLKDQVNQDDTQTSQNFLDIVLSAQAGDEKAFSDADLRSEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITWEQLDEIPYTTMCIKETLRLIPPIPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALTLLRFRVAADLTRPPAFSSHTVLRPKHGIYLHLKKLPEC
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MTSMVAPINMGLQFRGNWCNVNKNKGREFLKPNFNSSCNTNIALNNKRRFSLLVTASSQCSPGRIMGTINEIKHVPMIHPAAGKLANENKQHTTLVTLFRGRFVKDRSVYRQIFFVRSYEIGPDKTITVETLMNFLQETCLNHMSNCGVSQNDFGATHEMDLRKLIWVVTRIQVQVQRYSKWGEEIEVDTWFDIAGKNGIRRDWIIRDHYTKEIIAKATSTWTMMNRETRRLSKISEEVRQELVPFFFNKLAIAREEIDHQKIHKLTDSTAESFRYGVTPGWNDMDVNQHVNNVKYIRWILESVPREVLEDYKMTSMTLEFRRECTQSDLLESMSSSSSNVTGASNNDSVNTKPDLQYIHLLRLQDTKAELVRARTEWHLKQNHK
The following text describes a protein:
Function:
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTVISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSNEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVIRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQIFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVVRRRTAHAFKISKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKKKFGT
The following text describes a protein:
Function:
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity).
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPPSIFAEVPQAQPVLVFKLTADFREDPDP
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNPKFPILIRECSGVDPQLWTRYDMGVERYVRLDGLTESEINKKLEDLVKSGTSTNA
The following text describes a protein:
Function:
Plays a role in metaphase-anaphase transition during meiosis I. Required for embryonic anterior-posterior axis formation.
Subcellular Localization:
Chromosome. Cytoplasm. Note=At prometaphase, localizes around condensed chromosomes. At metaphase, localizes along chromosomes, dissociates from the sister chromatid after separation and localizes to the cytoplasm at anaphase and interphase.
Sequence:
MNNKGRTPGSAGRTVRSSAQQNGLTMRKRDMTPTRNTNLLPNATFVGDRFLGVRLDQDELDHANHLMTSKLYSNKENLNNSMSEPNSPEKKSVEGEALKQMMRHKSTGALTDADDGDRILCYKKNLAPPPAIGYINQAKVLYSTNSVINPASSVKKSTRHVKETATKVLDGPGLTKDLYSRHLDWGCHNWVAVALGHELYLWNTETCVIKNLFEDNAPTNEGLITSVRWSQEGRYISLGYASGAVKIYDPNRPKTTEYVRELRTLRVGGASRCASIAWRKQGVMTCGYKSGDIVNHDVRISQHVVSSWGGDNGHCRDVTALEWSADENMCVSGSSDRTAKIWDGRHVRGSTVIQDPEPMFTIDEHTGQVRTAQFCSFRDGILATGGGINDGTVKLWDVKRQFQKVRELNVCETGGVGGIVFNRPYSEMLTASDDGFLRIYRFNANYKLSHEIQASNEPIMDLVGSPFDEVLIGDMEETLKVFQLFNVDKSTNILDRTAPKNVGLNVR
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
Sequence:
MTALSDNLACIRQQITDAQARFQAMQPVTLCAVSKAQPATAIRAAYDAGQTVFGENYLQEALQKQAELDDCAIAWHFIGPIQSNKTQPIARHFDWVHSVDRLKIAQRLSNARPSDLPPLNICLQVNISEEASKSGASGQELLELALNIKQLPHLQLRGLMAIPAPCSDFEQQRDQFRQVRALFEQLNSHGLQLDTLSIGMSGDFAAAIAEGATLVRIGTAIFGARTPSLPTDSVKQGT
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
Sequence:
MFLNRLAATTRPYSSATRMALQAETKTADNPDERARDLLNCFNNINQQVEQAASGREVRLVAVSKLKPASDILTLYRTTGHLHFGENYVSELQEKVKALPGDIKWHFIGALQSNKCKILGAIPNLFAVETVDSLHKAQLLEKSRSGLASSVQVNPLEVYLQVNTSEEASKAGFITPSNEPILSSNLHSTAKYIKEECRWLKLAGLMTIGSIGQSKSDQGTNKDFERLVQLRDQLSESLGGLELGLSMGMSADFALAIKMGSDNVRVGSSIFGERPPFKKPET
The following text describes a protein:
Function:
Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MEKQCCSHPVICSLSTMYTFLLGAIFIALSSSRILLVKYSANEENKYDYLPTTVNVCSELVKLVFCVLVSFCVIKKDHQSRNLKYASWKEFSDFMKWSIPAFLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLSIVALTAGTKTLQHNLAGRGFHHDAFFSPSNSCLLFRSECPRKDNCTAKEWTFPEAKWNTTARVFSHIRLGMGHVLIIVQCFISSMANIYNEKILKEGNQLTESIFIQNSKLYFFGILFNGLTLGLQRSNRDQIKNCGFFYGHSAFSVALIFVTAFQGLSVAFILKFLDNMFHVLMAQVTTVIITTVSVLVFDFRPSLEFFLEAPSVLLSIFIYNASKPQVPEYAPRQERIRDLSGNLWERSSGDGEELERLTKPKSDESDEDTF
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MAANEMDVLQGLKQSSKGKLNYDLQPTKQELIEPCTTPLIIGIEYENVLQKFQNATSSSSSPTVKEASKTEGHPRSNEKPKKNEFLANASNDRSMTMYNLNYSMRTDYKKTTDISHVLLRSREKEKAEEVNERAKKRALMYKYHEEKLKEDKRLNLQKQQEELRNKILEDVQALQEDERNKTLQVRNKQREVEIEHREYAARAERKMREVEERQRLIAEEERNRQELAQLCSKHHEIHALVQKLDEAVKQCKYADYLPETTKTFLQESSKVFSLSQNTVKASVDMGRPAENAARLLDEYIGMLKVLLNKGMTAVAEAEQKGIKEKAETEAKKQEEEERKRDEEKKKAERAAAEARKKKEKAKSVPEYLVDCTSDSAFKEYTRLEKLLEKTEKEIEPLASSKEKDMKKLKLELQKAVTTPINTISDTSPSHLLEKIQTLKELLNGRAVTNTGKTISLSSHPLASLYCKNMLAKKIVQQGSGQVSSNHSAAFPSAAVAIDTRIQAQERNLTGSSFQSLFSPPVKPSPGYIIHQPTTTGEGFRIIIYLRR