lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for establishing sites of emergence of yeast and hyphal daughters and for maintaining the linearity of hyphal growth, but not involved in responses that require a reorientation of the direction of already established hyphal growth (tropisms). Does not play a role in penetration or injury of human epithelial cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell tip.
Sequence:
MLVQFQQLLLLLISIIKLCQADDNDNSFFQPVSQPSLNYKDTGNRIGLLGSFDALSFYSFVNSSQIVNDPDTSVSIFQKKRDVSNSSSSSTSFSNSLYLQDITNNYSLKFADINGQVNQLFKISNDSVVLNGNFTSFNNQSVISPIIFTISSREVTKIFSDDINGSVKTIFLDNDLIYLGGNFKFNNTYSAAVYNITAKKVHSTPFQGFGPNSSINSIAKVLNGDKEKEDNEEELGSILFGGQFDTLGLSDLLVHNITSNNTKKHNTSNTSIISAEQLISLRHGTFTSVNGESSEEDAAAIVCPSDNKEWAAQKNSGAEWKVELPDEMKGIHPTKARIYIPEGPNGIKLFRIYSYPNNGIMNLTYIDPATNELAYCDAWCPLLNYDDLNDHVDNNILNATELNENNSVFVDEQDGSYFQYYDPSTKTKNLGYASNFQEFAFVDNVGVDTVGVTIIDWYGDQGILAGFELYQNAITVYGNDSLNDPNCQSDASDDTNNNAVINSGSFKSVQSINPAITNTDYLVTSDTNAKITLYPNISYSGNYSIIMMTPGCAYDGSCARRAIVNVTVVGDDNDVLSTKTIYQNNENNKFDYLFYGHLNGSKTSTSSNRIEISYMGTVTEGVQDPYMVVDKVIANIVSLDNYYDKNSTNHTRNNTGYELAPIKLNGLFEYSLANFSQFDEQLVHYKRNNKTYISLNNTFVGNSSINLLSGELSNQSRIDQISLGPKQQDGNKQSLLLLGKFESDSKNITLSNNNLITLTIDSYNNTLNETNIELPSRLTKRDTQTILGGNFNNSITRLIELPGCFLAIGDFALSGKDGSSSIKDLSNNNQSVSSANNFALYSDDQWYSFGNDYTSNDFNQFTNLTLDSVEYYVFSGNGQFRTWDNDNFKWVTDPTKQLNLTQAAQINDHQQILGGTGFSTMQFQSVDQAYIADGNFSKFGIDVIANKSFMISNSYYVNSSLSVIGGKFETKDVKNVGLISNSDPNNTISALQGSIVWGDNTLIQSLYVDSSDEYLFMGVNGSVQINEQTNVTGIVIYDLVNNTFTSFQPAELSHSNGDPISVNSMVLFDKGNKLLVGGDFDLAGSLSCPSLCVYDITNTRWINPQNDATTTQSIGGVVTDMKFFQSNQVLITGNGLQLNGNSGIKFLIYNFNSNSFSVKDSLNKIDQTVEKFILNDENNKNLDGRMIAFGEKSISGFDGSNWQRIDSDIIYENFTKFNDMKLLTLDKPSDYNQTYFDKSQIFTIAGVFRLKDYGLVNMALFNGTSWIPYVFTSLQQQKSTGSGSGSGSGSRSSSLQIGQIQSILIDDSYRFQSSDDLKKTNKNLSRGKVVGISLACALGSTTLLGLLYIIPYFALFKNRKDGYFQPERIHEDEMMDAVNPEDLLHEIDLQREK
The following text describes a protein:
Function:
Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass membrane protein.
Sequence:
MSATSREGNKTKIGIVGGGIIGICTAFYLTEEQEYKKGELDIFIFESKEIAGGSSGIDSAILTKLCQNEIIQPLSTLALKLYEGLDKKFDGKKNWEYRTANSWFCKMKWDNTNVAKVPDTLQWLQRERMQKCSSIGSGNDFAMINPKLFCQFMAKEIEKRGVKFIFGSVKEVSKHHITYVPKQEAEDTIIKAQVHKTLVSAGPWTGYLLPFTGIAGLCIPIIHLSVGNFPVGDSIVVCCLNTMGNLNICKTTEIFSKNREQLIFMGTPKFHLLPKDSNRCFFNPFEIIELKEMTDLVLSENTKSNYLDASFKFLPTSRITGIPIISTTKSGVFVAAGHANWGITQAPATGLCMAEMLLGKEKTSINTDPFHLNLGE
The following text describes a protein:
Function:
Probable transcription factor involved in the development of floral organs. Required for normal development of lodicules and stamens (whorls 2 and 3). May function as a heterodimer with MADS4.
Miscellaneous:
MISCELLANEOUS: Inhibition of MADS16 expression by RNAi reduces expression of MADS4, and transforms lodicules and stamens into palea/lemma-like and carpel-like organs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MGRGKIEIKRIENATNRQVTYSKRRTGIMKKARELTVLCDAQVAIIMFSSTGKYHEFCSPSTDIKGIFDRYQQAIGTSLWIEQYENMQRTLSHLKDINRNLRTEIRQRMGEDLDGLEFDELRGLEQNVDAALKEVRHRKYHVITTQTETYKKKVKHSYEAYETLQQELGLREEPAFGFVDNTGGGWDGGAGAGAAADMFAFRVVPSQPNLHGMAYGGNHDLRLG
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MHSPDSIFEIYRRYCDIRSVKSCQVNEPDETRKGKSSRDSLAQLLKFVDLKFHSRIKIFDELLKLMSKLELMADFSEFSRFYDFVFFMCRENGQRNITVNKAVSAWKLVLAGRFRLLNQWCDFQENQRHNISEDTWQQVLAFSRCVHENLEGYDPEGAWPVLIDDFVEHMYRILGSNKEPNFFCNCGDSESRPCTFEDPLPGLKVAPGLKRKLPSFQDEEMDCSDALFPDSTRPNHILNSKTSRLLDYRH
The following text describes a protein:
Function:
Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose.
Sequence:
MVTRVESAGELVARAVSTFTDRFGEKPTTAVCGPGRVNLIGEHTDYNEGFVFPMALPMVTVVVGRKTDTGVCRVVTTAESADDPKQVEFPVPSTANPLQPGKPAWANYVKGVVANFKGEVCSFDAVLASSVPLGGGLSSSASLEVATYTFLEQLNPQDPPVSLKEKALACQKAEHEFPGMPCGIMDQFISVMGKEGHALLLDCRSMDAQLVPLDNPDVVVMVTNSNVRHELTGSEYPTRRRQCEEAAKILGKNSLREATMDDLEAHKDKFEPEVLCRARHVIGEIRRTTEAADALRARDYAKFGKLMVESHNSLRDDYEVSCAELDTLVSAAMECTGVYGSRMTGGGFGGCTVTLLSATAVQDTISHIKKKYTGEPTFYITTPAAGASVLQIP
The following text describes a protein:
Function:
E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome. Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane. Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum. Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response.
Subcellular Localization:
Endoplasmic reticulum membrane. Cytoplasm, cytosol. Nucleus. Chromosome. Note=Recruited to double-strand breaks by the MRE11-RAD50-NBN (MRN) complex following DNA damage.
Sequence:
MAADWEEIRRLAADFQRAQFAETVQRLSERNCIEIVSKLVEDKKLDVVHTLDGKEYVTPAQISREIRDELYMHRGRINVVDLQKIINVDLVHVEGRANEIAKSDRGTQLILGQLIDEAYLDRLAEEVNDKLQEAGQVNIAELCKTYDLPGDFLTEALNARLGRVIQGQLDQYNRGMIFTQAFLSRHKACICGLFSGITRPTQINNLLNLYGFQENLVYSMLEELVNSARLKGSVVGGRQDKAIYIPDIYSKAQSTWVESFLKQNGYLEFESLTRLGIPDPINYIKKRFKSSRLLFLKTACVGRTIVDQLEASVEEAINSATWVDLQPMLPSILSEEDVGILLNEVLRSMNVQSSARLLSTSVVSEKFIAGCIALFEDLMQQKAQKEVKNNPVFLITEDDVKQSSALLETSASSKKDKRDERRKKAAEGGGSVKSGGGGNAREIRIRKTKKKGRKEEDSDEETTHSSQGRNKLGDVQFLSVEEIVEVLEEKVCDSSEEMLQELAEQLQRPLSKMYQEVVTTAFLSTSSSGAGGSRKKNMKDLQEEINNLYNNIRLFEKGTKLFSDETQATVAKHVLKTVCTDVTNVLLSFVAAEHMTSDSSAAMTSEIRLKILAKLSDEVRSPLMKLHNSLNGKAIEEFLSCLETSAEECGLFLKKGDKKRERQALSVHRQALCEQLRDAEDPALVLHLTSVLLFQNVTHCMLHAPGRCVPHIIGFLQSKIPEDQHKLLSQYQSLVVKQLVVQGHGAEKKTVPPEGAGGPADSDDTESLQRELHSLSRDIKDTVLAQRKPSVTE
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSFGAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIAVTRTIPSLTSASTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLTLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKRSLGFLPQPAPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSVALSQRLCEMSGNEQQQEDLEKDSKLCPVEPDRSELENSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDENKENKTPEGSQGEIDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGSLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNFAMSGGIECFYFDASISENVEIGDNFSETVFVDGPCINVDTVAGAEKKSKSSILKSRGMITTCTENSFDPSPAPSQPQQSIQTTIKRPLLQFLNANNQQQTILIRFNNSNCKAQSQQDENCHAKSFLPLAGLGLKTCLDEMAKLKCRQCSYQACYGKQLEEHVSTLHSSEALDRCLCCQMIFFNDDDLKIHYQKNHPKCYCSECGFISQHGYVMRRHMQSHTEEGRKCMFCSKLYKDRYVLNMHLKMVHSPVEKSFTCTTCSKSFNRKAHLVRHERTHAPKKPFICHHPNCNYSASERSDLSKHSLVHGEPQFKCNVCSKKFRQSKNRDLHLKRYILIY
The following text describes a protein:
Function:
Probable RNA-binding protein that plays a role in meiosis and vegetative growth.
Sequence:
MPSEVLDLKGLSSSSFFSDDLRHTDEGQVGVWKSASVPNHRASNISGSSSSVEKFSIGECLPENSLENHDSFPVRDQNASLILNRHAVGAERTSNYFSRSNEVNMMNSQYESSLFSSSLSDIFTRKLRFSPSNALYGHSVDTVASHFEEEEVFESLEELEAQTIGNLLPDDDDLLAGVTDGLDCLVETTGEDDAEDLDFFSNVGGMDLGDDGLSVGQKNSESPGLFNNLPGMHNGAMAGEHPLGEHPSRTLFVRNINSNVEDSELEALFEQYGDIRTLYTACKHRGFVMISYYDIRAARNAMKALQNKPLRRRKLDIHYSIPKDNPSEKDINQGTLVVFNLESSVSNEELRQIFGVYGEIKEIREAPHRSHHKFIEFYDIRAAEAALCALNLSDIAGKQIKLEPSRPGGVRRSLVQQLHPQLEREDIGLYLQQGSPPVNCSAGFSGLVPSGTIKSSSLSNGSVLGVHSLLRAPSLDTVLHHGISSSVPSSLPSVMRSESTGNQSGFIDSGHSPSQLKLGIRASSAVHPHSLPEHPDGLNNNVHCNSLNAIGGNINLRPPERADSRQLCGVNFNGRSIELNEDVFASGGNRTCPIPGPHYGWGNSYRPQPPAPGVVWPNSPSYMNGIAAGHTPTQVHGVPRAASHLMHTVMPMNNHHVGSAPAVNPPSIWDRQHYAGELSKASGFHSGSIGNMNLSNNSPQSMDFFSHIFPQVGGNSVELPIPQRNVGLQSHHQRCMVFPGRGQILPMMNSFDSSNERGRSRRNEAASNQADKKQYELDIDRIMRGEDNRTTLMIKNIPNKYTSKMLLAAIDERHRGTYDFIYLPIDFKNKCNVGYAFINMTDPGLIIPFYEAFNGKKWEKFNSEKVASLAYARIQGKAALIAHFQNSSLMNEDKRCRPILFNTDGPNAGDQVPFPMGVNVRTRPGKTRTNTPDENADEGLLISGNGENYPSGDTSSSCLVKDLDQPVP
The following text describes a protein:
Function:
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.
Miscellaneous:
MISCELLANEOUS: DusB and DusC together account for about half of the 5,6-dihydrouridine modification observed in wild-type cellular tRNA, and DusA accounts for the other half. These three enzymes seem to act site-specifically on the tRNA D-loop and contain nonredundant catalytic functions in vivo.
Sequence:
MHGNSEMQKINQTSAMPEKTDVHWSGRFSVAPMLDWTDRHCRYFLRLLSRNTLLYTEMVTTGAIIHGKGDYLAYSEEEHPVALQLGGSDPAALAQCAKLAEARGYDEINLNVGCPSDRVQNGMFGACLMGNAQLVADCVKAMRDVVSIPVTVKTRIGIDDQDSYEFLCDFINTVSGKGECEMFIIHARKAWLSGLSPKENREIPPLDYPRVYQLKRDFPHLTMSINGGIKSLEEAKAHLQHMDGVMVGREAYQNPGILAAVDREIFGSSDTDADPVAVVRAMYPYIERELSQGTYLGHITRHMLGLFQGIPGARQWRRYLSENAHKAGADINVLEHALKLVADKR
The following text describes a protein:
Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation.
Subcellular Localization:
Cytoplasm.
Domain:
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Sequence:
MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Sequence:
MRTVFLFLLVAFPALDFGSACEEARKKRDLLVRTKRRWVLSTIELEEEMIVNYPYFISKMYNDKIQGKDFRFEITGEAVTEGYLTINENTGEVFVLKSIDREKYPCFHVIFNVYDTDTNQKIDKELAFDVEVKDINDNPPRFTKFPKTFTVNESQAEGSLGVEVIAQDIDEKNTKNSTFNITVVQQTPLEPNIQAKWIDERTVHLNFTGCFDYEKAKEYKITLEAKDHGTPPLSSTAVITLNVRDTNTHMPEFKKKEFQTEVHEMKLYRDVFRFPVEDKDTPNTDGWHAKFFFISGNEEGIFKVETDPKTNEGIFNIVKEKNYEITTMVELEIGVENIEPFTKCVNGKLIKQDGKLYRPDSISVTITIIDDNDPPVFQPPKADVYEKEESEPGRVLFTPKVYDPDSSSFRFELVDDPANWVSIDEKTGEIRAIKKMDRESPFVDADNVYKVVIAAIDDGKPPAKSFCNVSIHLRDINDHKPQLVNNSLILCGNKNNKVMIPVQDLDAEPYSGPFSFYFDDEEDKKHWELDPAYGQQGGLVSLKPLPYGNYSIPLRMQDQQNNEGHETLEVVVCDCAEKNTCRSKLALSTKLGGPGFGLIIVGILLFLILLLTFLCNSGREPLKELKDEGNQTLIKYNQEGGVSACNAEPVLSSPKTVPDGIKQTSITRRFEMAPEFYHNEEMYRSELNMMRSMNFQHQKESYRTQEGRSMYSSLASNRMSSYRNKSMDRYSSVRSDLRSDYNLTGQVERKMAVIAEADARDKAVDRPFIYNFEGQGSKCGSLDKLSLSNLGDNLQFLDDLGPKFKTLADICQ
The following text describes a protein:
Function:
Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.
Sequence:
MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVNEINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGADCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVMREETIKSLEDPYKYHYKEEWLNTKDPDEQQLFEIFAFGNIKDLPENIILTSLMRSKLEKLTLVTLSEIYNELSYELIKEECQIEDDGIIESHLIQLQNIFKAEMDSVSKSMKFSRRFDCRDVYCHEKELTIIKNPRVTKEYLVQNLRSWETKLKQNILE
The following text describes a protein:
Function:
Tip subunit of the minor fimbriae. These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. They play an important role in invasion of periodontal tissues and are recognized as major virulence factors. Fimbrium subunits from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).
Miscellaneous:
MISCELLANEOUS: The name (minor fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
Subcellular Localization:
Fimbrium. Cell outer membrane. Note=Targeted to the outer membrane as a palmitoylated precursor. The lipid modification is no longer present after proteolytic processing to the mature form. Detected at the tip of the fimbriae.
Sequence:
MMQLKKRYFALILLLFLWSGCDRGVDPQPDPLQPDVYLLVNARAAHTNGEESINMDAEDFEDRVHSLAMLVFDSNTGEKVAEHFSSSIGSGTSTYVFTVKLKPGQRDFFFVANIPNMQTAMASIVNKSDMNHFMQVFRDLDPIHYHNATNNNGFPMSRMYSNQTVTIGGTITQPLPFKPDGENNVKLQRVVAKLDVNIVEGVENLQKIELCNANVHYRLVPNQSEPIQFYGPVELRRVGATNQWLGYMPEAIVESTKWWGNTGNAENKPINFFRLTTRGGLVYDVPIITHEGAIPGGQYLPFAKGLLADKPSYTVYRNRHYIYRIKTLPDKIEVKYSICDWNIVTNDTYMGYGYNVGVDEQGNVTITNTMQNCDPHVVRLVAKNGAYFGSQPTDTSVEFTELANGASQTFKVNKDAVAVGSAYLEVYYNPDLNATGVVPDKVFIKK
The following text describes a protein:
Function:
TesA is a multifunctional esterase that can act as a thioesterase, lysophospholipase and protease. TesA functions as a thioesterase specific for fatty acyl thioesters of greater than ten carbons, with highest activity on palmitoyl-CoA, cis-vaccenoyl-CoA and palmitoleoyl-CoA. TesA also possesses an arylesterase activity towards short acyl-chain aromatic esters such as alpha-naphthyl acetate, alpha-naphthyl butyrate, benzyl acetate and phenyl acetate. Also able to hydrolyze short acyl-chain triacylglycerols such as triacetin and tributyrin, and p-nitrophenyl esters such as p-nitrophenyl hexanoate and p-nitrophenyl butyrate. The protease activity is mainly active on small peptides. TesA is also able to hydrolyze p-nitrophenyl esters of N-substituted amino acids such as N-benzyloxycarbonyl-L-Phe-p-nitrophenyl ester (Z-L-Phe-ONp) and N-benzyloxycarbonyl-L-Tyr-p-nitrophenyl ester (Z-L-Tyr-ONp), however it is unable to hydrolyze N-acetyl-L-Phe ethyl ester and its Tyr analog. TesA also hydrolyzes N-benzyloxycarbonyl-L-Phe beta-nitrophenyl ester (Cbz-Phe-ONap) and N-acetyl-DL-Phe-2-naphthyl ester (chymotrypsin-like specificity). Shows a slow proteolytic activity against denatured casein. The lysophospholipase activity of TesA is able to hydrolyze 1-palmitoyl-sn-glycero-3-phosphocholine, 1-acyl-sn-glycero-3-phosphoglycerol, 1- and 2-acyl-sn-glycero-3-phosphoethanolamine.
Subcellular Localization:
Periplasm.
Sequence:
MMNFNNVFRWHLPFLFLVLLTFRAAAADTLLILGDSLSAGYRMSASAAWPALLNDKWQSKTSVVNASISGDTSQQGLARLPALLKQHQPRWVLVELGGNDGLRGFQPQQTEQTLRQILQDVKAANAEPLLMQIRLPANYGRRYNEAFSAIYPKLAKEFDVPLLPFFMEEVYLKPQWMQDDGIHPNRDAQPFIADWMAKQLQPLVNHDS
The following text describes a protein:
Function:
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Essential for the development of natural killer (NK) cells, B cells, and dendritic cells (DCs).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; [Isoform 3]: Secreted. Note=Biologically active; [Isoform 4]: Secreted. Note=Inactive.
Sequence:
MTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISSNFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKALWSLFLAQRWIEQLKTVAGSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHLLKDTCTQLLALKPCIGKACQNFSRCLEVQCQPDSSTLLPPRSPIALEATELPEPRPRQLLLLLLLLLPLTLVLLAAAWGLRWQRARRRGELHPGVPLPSHP
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MADLGERGQVQRNDSTPALQDESDPKKKDLLICKAEGKELSKEEKQRLRKEKKQQKKNKKEDKGSADNEKEKKAVVPAIGQQTQTQKVHSAAPQLGSVSEAPAGVEKSAPAKSKAELRAERRARQEADRAAKTGKKDPGQPPSTAKPKALPSEPQPVVKRLPEHIQVDDPAVLKKLAKKLERQQIPLRSEYGHKVSLFSHLHQYSRKAPLTQQISIPSTVIHPSIVRLGLQYSHGIIAGSNSRCIALLHSFKQIIHDYTTPPNEELSRDLVNKLKPYISFLNQCRPLSASMGNAIKYLKKEISNISSQCKEEEAKSKLLSCIDRYIEEKIHLAAKAISKSAFEKISDGDVILVYGCSSLVNYILCDAYERGRKFRVIVVDSRPRLEGREALRRLVRKGICCTYVLITAISYILHEVSKVFVGAHALLANGYVMSRVGTSQIALVAKAFNVPVLVCCETYKFCERVQTDSFVSNELDDPDDLIVTRKGNTQLEKWQEISSLRLLNLVYDVTPPDFVDLVITDLGMIPCTSVPVVLRVKNVDQ
The following text describes a protein:
Function:
Probable circularly permuted 1,3-beta-glucanase involved in cell wall modification through beta-1,3-glucan network alterations such as increased branching or remodeling (By similarity). Plays a role in engulfment by host macrophages.
Subcellular Localization:
Secreted.
Domain:
The conserved ExDxxE motif might be important for catalytic activity.
Sequence:
MKFSSTTLLAGLSSLTATVSAGCSFEGGNYYCSETKKVIYKGIGFSGTYMDVTNMDESTGKCTQQSYSFSGNLSPLDEELSVHFRGPLTLLQFGVYYPSSSGNSKRQIDDQDCNVKHVHHKHKRATEVVQVTQTVFVDGNGNTVTSQALQTSTVESSPAVSSAAADDNANSGSGSGSSAGSGSGYGSVSALDGEGKAYRSDISTKSAPTSTSAQPSSSETASVDGAWTRDSYYTPGSTDNCVFLNYHGGSGSGVWSAKFGNSLSYANADNSGGSSTPVPLEETTIKSGEEYIIFSGSKCGSSSDCGYYRKGTVAYHGFKGASKIFVFEFEMPSDTNGNGYNQDMPAVWLLNAKIPRTLQYGEATCSCWKTGCGELDLFEVLSSGSNKMISHLHDGQGSSQNSNNGGGGSQDYFERPTSGTFKGVVIFEGDEIHILQVDDETEFGSSLDEETVNAWLKEAGSVATIGY
The following text describes a protein:
Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MCDQLAFASQRKPYQHMDLRHHVRDIPDYPKPGILFRDITPLLAHPEALTASVEEMAKPFLDQKIDVVAAAEARGFIFGTPLAMRLNAGFVPIRKPGKLPFDLHSFAYELEYGSDELQIHVDGIKPGQRVLIVDDLLATGGTVEACLRLLEKCDAEIVGCSFLIHLVALGGEARLSPYHVHSVLEYGGDDAEDELSIQNRPPGPSV
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Membrane; Single-pass membrane protein.
Sequence:
MSSLASQLQSINEKTASVALDRKQRSKLHSRSLIFDPKQAATQDYEYIYEIATEGLEDLCELDSRFNKFKSTLFSETSVNLDRNLQTKDVISQLDKNIDAFLTLVGPYYGLTSSLKAVEWLVRRFHANIHNAELMILTALPYFQHPVFVKVLNVIPKQNLPQIFEWLVGYKDQLKTPPASSILKAFRNDFHFFNFYSKFLNDQIKNHTVYKEQLVFYLSNTVQLLASFSKNIEELNETHIPVVLETTALMLLPQQKPKYSSSINSDLKLTSYSIISVLSSIFPFSADILKSLTVSILEDEDALKGFTKPTLIVLSQLWKHFQGNLEVIEAFKNFKIGQHELGVLDELKNENYQLSTFIILVFISTFPSNESYKLLPFIDLSNKTVFEIITKLVLQNSTTQEDSIRSNLTKIAQSLTKSDPKLFQTTLESENWKVDELELKLMSVLVESKNDEAEFDAGDEDNAVEDIEIVKTVDFTKLQSTAKSYFNTEYDEEFNLVLKELKSVLSASDAKLHVSVILTFLQKVFSTPEVALTFAFRVALTPAVPLSIRLSAIKSIRIKIKNAANGKTDFYLLIPLILLALFDNSKLIRSGFAQLLRLVIEIKTKLTTGAALFLEREIYGSVSDKKYPTPHDSLFLCSLLSEDNVKDTVLDPSRVINILFDSIFKAKNGKSKPGKYFRSFIFTQWSLCSLPIVLKANAWKIVAQANKAGTDDRFFFLDGDIENYFSKRNVWIDQASIAGIAFFDNAEVSVVGLVGGVASNDKNSNTESEWLCRALENPSGNLQMTANNRVLETFDTFKPIESRLKIVNKLVDILINDDIVEFDPMATLQELNIDRNLFLQALTSVQIGDQIPEQGIAKRRRRSSNSTKQAMVRDEINNMASGHLKKLTFLLEILESSLRKKRNVAGPDLLKVLFKILTDLEYLGNDGNLPVLYAQETLASCMLLNIVNLKSSSKEVKFDSNSIRADLIVNSIRASPSPQVQNRLLLVISELASLAPEVILHSVMPIFTFMGAHTVRQDDEFSSSALQQTVAKVIPALASNGLSPVNNEIEFLLASFATAFPHVPRHRRVKLFVSLTKTLGCAESMHLILFLMGQQYANNVHKNKNGDSQSVVEFVHGYMKSFSAEEQLAGIVAFTKLWNDIPLNQLEPGSEEFEVLNNRPVFGTTIATLGQSGLAVLRNDLLQFLDETLSSENKHELSSLKTKMALVLIDDEDSEVSKKESVLDKFRAITSFALASLDTFTNSHADIKLCSTLYSLLGNLLDLLPLNYFIDSIVASLDVDTLSDSLSIKVARNYAILASRKFETELNVAHCDQVVIESVINNLLPILIKGIKKNVDVELQQAYLDTFSTIVNKFGASGTEFASSDVSKVLIESLGIVTTDRGLLNEQPEVIIASINAITSIVNILGVKTLGLFPKVVPPALKIWESTNSLGDKESAKLLQGSVLVLLSCYIKKIPAFMSTTLEAVLLTILSSDLIDNHIRSSVLDLIVDHMDLAQVLKSLCNVWLTKKFYTNDNSGNIGLFLKTLQATINKMEKKQATTQATLFMRWLISAFEFRQYSEDNDNKFDNNTIHRLESSFHGCAIAFVMKLNDKSFRPLFANLVRWAVDGEGATLKTNEVSRLLAFFRFFNKLQDELKSIITSYFSYLLDPTSALLKRFSEGSLVATNLRRIILIGLTSSFKYDQDDYWSQQGRFDSICSPLLSQLSNIEDSIGKYLVKSVSTFVTDVSSDEYNETLVHELIKYISNANENSAATKIWSIRTLKTIFQKMGEQWLSYLPTLVPYIAELLEDDDEEVEMEVRRGLVRVIENVLGEPLDRYLS
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MSRPSSIYRPGNSSLTSRRIHHVIPQDSFPLLDFKEISICLQSCDFIANEELVSRPTSQYIKTLLEQLLDSFMGLSADNINGMVRNVNKNDLSMTKTQDAQMEEEPENGGSQIEDDDDITSSVRLILLHRGAYEFFSICGVNDFTLMDIMRPEPQRIRRILSAVVNYARFREENSVECEKLVSISEGNLEQLKVVQNENSRLSNKINDLKYKIEANETDEGNKKATLKQITTYNSKLENELKKLKKNQEILTLEHSKYKDEKRRLIEKLEDHNYLIMESNKELDKLKSYLLSNPEILTKIIEDLKTNLSEYQTNLADLESKNKNMTISIESFQLVEQELKNLFRILEEVLNDLTKEETSLDKLNKYQEFKEQQNLTLNDLNRQIQQVTRQLNNTEEKIKRLRHQSSERSEASKQKLISLKDGYDTLVKERKVKEQELNKKKDFISELETKMNGERSNFQIELRNAELAVAKLNSHVKLYLTEMNKKVD