lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MARFGDEMPARYGGGGGGGGGGGAEGAAGGAAAGGGGGRGAGGSRQGGQPGTQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPYPLPAARPLDAPSPANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILAKVGTQFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFDLVTGDIKSEGPCGVDEPARICPNGTKCDQYWEGPNYGITQFDNILFAVLTVFQCITMEGWTDLLYDSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDALRRATIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKRERRMRFYIRRMVKTQAFYWTVLSLVTLNTLCVAVVHYNQPDWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVVKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDDGTPPTNFDTFPAAIMTVFQILTGEDWNAVMYDGIKSQGGVKRGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKSSKSVWEQRTSEMRKQNLMASREALYNELDPEERWKVSYARHMRPDIKTHLDRPLVVDPQENRNNNTNKSRPSDPSVDQRLSQQRAEDFLRKQARYHDRGRESNGSRSYERADSGGLEPRRQRSGSKEADLNREGPYGREPDYHTGDRDGNQDRGFREGGLEHGKTGDPHRRHQHRQGGSKESRSGSPRAGEGEREPRRHRAHRRVGEEGAEDSNKAERRFRHREGSRPARDGEGEQQDGERRRRHRHAAAQATYETEPKRDDKERRHRRRKENQGSGVPVTGPNLSTTRPIQQDMGRQEPPLAEDIDNMKNNKLATTEPTSSHNAINAVNPQSPAKMGNHANPTPPRSTHGLPGPPNQTPNPQNAANRRAPNNPGNPSNPGPPKNPDNSLIVTNPSTQNNPAKTAKKPEHTAVDIPATFPPPINNTVVQVNKNANPDPLPKKEEEKKEEEEDDLGEDGPKPMPPYSSMFILSTTNPFRQLCHYIVNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGKFFFCTDESKEFEKDCRGEYLVYEKDNEVKAQKREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGATTAYENVLRMFNIVFTSLFSLECLLKIMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDDEDEGSHITEHNNFRTFFQALMLLFRSATGEAWHDIMLSCLSGKPCDENSGIKEPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQALREEQNRTPLMFQRMEPPSPTQEGGLGPNSLPSSQLDQGGGLMTHEGGLKESPSWVTQRAQEMFQKTGTWSPERGRPEDVPDSRPNSQSVEMREMGKDGYSDSDHYLPMEGQGRAASMPRLPAENQRRKARPRGNNLSTISDASPMKRSASMLGHSRSKGIRLDDYSLERVIPEENQRHHQRRRERSHRTSERSLSRYTDVDTGLGTDLSVTTQSGDLPSKERDQERGRPKDRKHHHHHHHHHHHHTSSDKERYSQERHEYSRPRSRDQRWSRSPSEGREHMSHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKATDTGPQPQQQPVHPCRAPPPGPRRYPTLPSEHQGGERPAGSSHGSSRSPGMERHAMAPPRNDSPWAYRHAGGRWATAGSHPSEAHPGPRHHSGYYRSSDYDAEGPGSEEAAFAYEPPPPPASSGSGRSPRTSRAGGPASVSPSRHGRRLPNGYYHSHGLTKPRGTGSRKGLHEPCSETDDDDWC
The following text describes a protein:
Function:
Plays a central role in integrating RNA silencing and chromatin signals in 21 nt siRNA-dependent DNA methylation on cytosine pathway leading to transcriptional gene silencing of specific sequences. Involved in a chromatin-based RNA silencing pathway that encompasses both post-transcriptional gene silencing (PTGS) (e.g. RDR1, RDR6 and AGO2) and transcriptional gene silencing (TGS) (e.g. siRNA-dependent DNA methylation and histone H3) components. Mediates siRNA accumulation at specific chromatin loci. Binds H3K4me0 through its PHD to enforce low levels of H3K4 methylation and gene silencing at a subset of genomic loci.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger (599-665) binds to unmethylated histone H3 'Lys-4' (H3K4me0).
Sequence:
MDSDSERASLESIKDNSECVHVSNEPNLTATCVDSSVGEEGVTDVNSSAAVSELVPPEQGEGALLNSVPEISERGIPVDVVSSVDGGGEENAAFNIQEIDSVGGDAAAVEEVPLKSSSVVGEGREEEAGASIVKEEDFVAEANLSGDRLEENKEVSMEEEPSSHELSVCEVNGVDSLNDEENREVGEQIVCGSMGGEEIESDLESKKEKVDVIEEETTAQAASLVNAIEIPDDKEVACVAGFTEISSQDKGLDESGNGFLDEEPVKELQIGEGAKDLTDGDAKEGVDVTEDEMDIQVLKKSKEEEKVDSTTELEIETMRLEVHDVATEMSDKTVISSAVVTQFTGETSNDKETVMDDVKEDVDKDSEAGKSLDIHVPEATEEVDTDVNYGVGIEKEGDGVGGAEEAGQTVDLEEIREENQELSKELAQVDETKISEMSEVTETMIKDEDQEKDDNMTDLAEDVENHRDSSVADIEEGREDHEDMGVTETQKETVLGKVDRTKIAEVSEETDTRIEDEDQEKDDEMTDVAEDVKTHGDSSVADIEEGRESQEEMTETQEDSVMADEEPEEVEEENKSAGGKRKRGRNTKTVKGTGKKKEEDVCFMCFDGGDLVLCDRRGCTKAYHPSCVDRDEAFFQTKGKWNCGWHLCSKCEKTATYLCYTCMFSLCKGCAKDAVFFCIRGNKGLCETCMETVKLIERKQQEKEPAQLDFNDKTSWEYLFKDYWIDLKTQLSLSPEELDQAKRPLKGHETNASKQGTASETDYVTDGGSDSDSSPKKRKTRSRSKSGSAEKILSSGDKNLSDETMEWASKELLDLVVHMRRGDRSFLPMLEVQTLLLAYIKRYNLRDPRRKSQVICDSRLQNLFGKSHVGHFEMLNLLDSHFLKKEQNQADDIQGDIVDTEEPNHVDVDENLDHPVKSGKDKKRKTRKKNVRKGRQSNLDDFAAVDMHNINLIYLRRSLVEDLLEDSTAFEEKVASAFVRLRISGNQKQDLYRLVQVVGTSKAPEPYKVGKKTTDYVLEILNLDKTEVISIDIISNQDFTEDECKRLKQSIKCGLINRLTVGDIQEKAIALQEVRVKNLLEAEILRFSHLRDRASDMGRRKEYPYLLKLSNSLTMLTLRECVEKLQLLKSPEERQRRLEEIPEIHADPKMDPDCESEDEDEKEEKEKEKQLRPRSSSFNRRGRDPISPRKGGFSSNESWTGTSNYSNTSANRELSRSYSGRGSTGRGDYLGSSDDKVSDSMWTSAREREVQPSLGSEKPRSVSIPETPARSSRAIAPPELSPRIASEISMAPPAVVSQPVPKSNDSEKIWHYKDPSGKVQGPFSMAQLRKWNNTGYFPAKLEIWKANESPLDSVLLTDALAGLFQKQTQAVDNSYMKAQVAAFSGQSSQSEPNLGFAARIAPTTIEIPRNSQDTWSQGGSLPSPTPNQITTPTAKRRNFESRWSPTKPSPQSANQSMNYSVAQSGQSQTSRIDIPVVVNSAGALQPQTYPIPTPDPINVSVNHSATLHSPTPAGGKQSWGSMQTDHGGSNTPSSQNNSTSYGTPSPSVLPSQSQPGFPPSDSWKVAVPSQPNAQAQAQWGMNMVNNNQNSAQPQAPANQNSSWGQGTVNPNMGWVGPAQTGVNVNWGGSSVPSTVQGITHSGWVAPVQGQTQAYPNPGWGPTGHPQSQSQSQVQAQAGTTGSGWMQPGQGIQSGNSNQNWGTQNQTAIPSGGSGGNQAGYWGNQQQSQNGDSGYGWNRQSGGQQNNFKGQRVCKFFRENGHCRKGASCNYLHN
The following text describes a protein:
Function:
Serine/threonine-protein acetyltransferase translocated into infected cells, which inhibits the host immune response and induces cell death by mediating acetylation of target proteins. Inhibits the MAPK and NF-kappa-B signaling pathways by acetylating protein-kinases such as MAP2K1, MAP2K6, MAP3K7/TAK1 and I-kappa-B kinase (CHUK/IKKA and IKBKB) on serine and threonine residues critical for their activation by phosphorylation, thereby preventing protein-kinase activation (By similarity). Promotes pyroptosis, a programmed cell death, in host cells by mediating acetylation of MAP3K7/TAK1: MAP3K7/TAK1 inactivation triggers activation of caspase-8 (CASP8), followed by CASP8-dependent cleavage of gasdermin-D (GSDMD) and induction of pyroptosis (By similarity). Also able to induce intestinal barrier dysfunction by acetylating and inhibiting host protein-kinases RIPK2/RICK and MAP3K7/TAK1, thereby promoting cell death.
Subcellular Localization:
Secreted. Note=Secreted via type III secretion system (T3SS).
Sequence:
MIGPISQINISGGLSEKETSSLISNEELKNIITQLETDISDGSWFHKNYSRMDVEVMPALVIQANNKYPEMNLNLVTSPLDLSIEIKNVIENGVRSSRFIINMGEGGIHFSVIDYKHINGKTSLILFEPANFNSMGPAMLAIRTKTAIERYQLPDCHFSMVEMDIQRSSSECGIFSFALAKKLYIERDSLLKIHEDNIKGILSDGENPLPHDKLDPYLPVTFYKHTQGKKRLNEYLNTNPQGVGTVVNKKNETIVNRFDNNKSIVDGKELSVSVHKKRIAEYKTLLKV
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Also plays a role in the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAVFKLIKPAPLTEKVQSRQGNIYLYRAMWLIGWIPPKEGVLRYVYLFWTCVPFAFGVFYLPVGFIISYVQEFKNFTPGEFLTSLQVCINVYGASVKSTITYLFLWRLRKTEILLDSLDKRLANDSDRERIHNMVARCNYAFLIYSFIYCGYAGSTFLSYALSGRPPWSVYNPFIDWRDGMGSLWIQAIFEYITMSFAVLQDQLSDTYPLMFTIMFRAHMEVLKDHVRSLRMDPERSEADNYQDLVNCVLDHKTILKCCDMIRPMISRTIFVQFALIGSVLGLTLVNVFFFSNFWKGVASLLFVITILLQTFPFCYTCNMLIDDAQDLSNEIFQSNWVDAEPRYKATLVLFMHHVQQPIIFIAGGIFPISMNSNITVAKFAFSIITIVRQMNLAEQFQ
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MSKSRVNTVKSNDANALFKSKSLSQIPSSPLKPRELTRINPSSPATSVIPAGTEDARRSFDEWMKIAAENNISTANTWNLALIDYFHDMSVLRDGSSINFQKASCTLDGCVKIYTSRIDSVDSETKRLLDSLADRENRPENGETAIVSSVKTKSKSSAKTLQEDVTELNWKHMDAEFSVDPLFKKTAAEFDEGGAQGLLLNHLMISADGKVLFDASDVMMDSSTADDMAPLSCGSDILSAHFEQLFAKIKGNLSSLDNFDICPTFSSFRFDNSEFYPKTPAKYDTMMQQQDDPDDYGDVDNYDPYDQGPMVEDDDGYENYNQDSASQSIHPLNLEDISSMSIAGETDEPESDAQMSSQLFSYFDANAARNWAGPEYWRSRSLRVNKKTEGSVESTNAAKPKRSQQAPTLDFLSNVPIDREAIFTPPAKPSLLPKNSTKELSTHQLPPDMHVSSANFLKYFLKPHLQVSIDARSTNRVEPSIGQILDDGNDAGMHTITDENEYNNPLEYAGDDDGDEYYDFGQGGNDGHPSDPTMYNSKHSVDNSNIIDLSLDQGGDYKSHLGTMLSAGVSRQSIAPLVGLARSAKRVDVKKLKDNIWKTIDVERDESNSLQNTCAPDITKQSEYHKPKVFSSVVSELCHAYSPAAYNDISVAFCFICVLHLANEKNLEIHGSSELEDLQITVPNA
The following text describes a protein:
Function:
Involved in transcription-coupled repair nucleotide excision repair (NER) of UV-induced DNA lesions.
Subcellular Localization:
Nucleus.
Sequence:
MDPFLEFRVGNISLNEFYRRTIQSEFERILEDPLSNMKNYRFSKQSNYSTKEKTPLSIGVNCLDIDDTGQVLLGGGDDGSLSIWGLDESLHRNDEGEQELINKRLNYIKRQPHQSDDEPAQIMGYKNKRTRINDNNTMRLVHSFQTQRNKYRMYRQSSAAVPVQRSHISNKTDSPIGFSETLSETDSEASISHHKYGITTLKWYKADNGMFFTGSNDKTVKIWDTNRFEAVQDINLGYKINQIDNNVVDDSSLLVVASEDYYPRLIDLRTMNSGVTALGMGNQTRMQSEILCCKFNPVREQIIACGDMEGGVKLWDLRMRNRLYSELKRNKNRFKTINNDDNDDQSDVYFSSNQSKAHLRCCSDIVWNSEGSELCSVGMDGKLNVWRPFTEILQPEGLASYSQLGTQDLSRIKYKKRVSRRLLWFDKFLLCITDNGEVEIYNTEEKKLWNKLEYPMVNQVKKNQASHCQFSSMIVQTNIMNSVGLKLFFGTNNNTVSDGGSIFECS
The following text describes a protein:
Function:
Specifically binds to the fungal elicitor-responsive DNA element, 5'-CTAATTGTTTA-3', of the gene PR2 promoter.
Subcellular Localization:
Nucleus.
Sequence:
MEESETKGRISQETDKACVSVERIGSTLLSSFVKKGKEVSNKRNSKQNKRKAEEELCSKSRTKKYSRGWVRCEEMEEEKVKKTRKRKSKRQQKDNKVEVDDSLRLQRRTRYLLIKMKMQQNLIDAYATEGWKGQSREKIRPDKELERARKEILNCKLGLRDAIRQLDLLSSVGSMEEKVIASDGSIHHDHIFCAECNSREAFPDNDIILCDGTCNRAFHQKCLDPPLETESIPPGDQGWFCKFCDCKIEIIDTMNAQIGTHFPVDSNWQDIFNEEASLPIGSEATVNNEADWPSDDSKDDDYDPEMRENGGGNSSNVSGDGGGDNDEESISTSLSLSSDGVALSTGSWEGHRLSNMVEQCETSNEETVCGPRQRRTVDYTQLYYEMFGKDAVLQEQGSEDEDWGPNDRRKRKRESDAGSTLVTMCESSKKDQDVVETLEQSERDSVSVENKGGRRRMFRLPRNAVEKLRQVFAETELPSKAVRDRLAKELSLDPEKVNKWFKNTRYMALRNRKTESVKQPGDSKTVSGGDSGPEAVMENNTETNEVQDTLDDTVPPGFDATNQNILSPCNNNQEEFQQENVSFPSPTDESQQYLEQNDSSFVLVPHEKQSSEISLKTAVEENETESKMMKEPHEELSSEMSLKTAAEEKETESKMIEEPHEELSREMSLKTAVEEKETESKMMEEPHDELNSEMSLSTAVEEKETGSKMTEESHEELSNEMSLEEKETGRKMTEEEELEAVMEMLCRTENKLLDVTQRLDRFKTPKGRKKLGNSSSPLLEEDSVVYVPIAEIKEKR
The following text describes a protein:
Function:
Histone acetyltransferase that catalyzes the formation of the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction and constitutes the only acetylation mark intergenerationally transmitted. Catalytic component of the male-specific lethal (MSL) complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). The MSL complex specifically associates with the single X chromosome in males and mediates formation of H4K16ac, promoting a two-fold activation of X chromosome. Dosage compensation ensures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. In oocytes, mof is also part of a maternal MSL subcomplex that mediates H4K16ac deposition for intergenerational transmission: H4K16ac prepares the chromatin landscape for establishment of nucleosome accessibility and poises genes for future activation. H4K16ac constitutes the only acetylation mark maintained from oocytes to fertilized embryos. Mof also constitutes the catalytic component of the non-specific lethal (NLS) complex, which promotes expression of housekeeping genes on X chromosome and autosomes. The NSL complex promotes strong expression of housekeeping genes compared to the two-fold expression mediated by the MSL complex on X chromosome, suggesting that the activation potential of mof is constrained in the context of dosage compensation.
Subcellular Localization:
Nucleus. Chromosome. Note=When part of MSL complex, specifically localizes to many sites on the male X chromosome: displays a bimodal distribution binding to promoters and the 3' ends of genes. Recruited to the male X chromosome following association with roX1 and roX2 non-coding RNAs. As part as the NSL complex, associates with promoters of housekeeping genes on X chromosome and autosomes genes.
Domain:
The tudor-knot domain (also named chromobarrel domain) mediates association with roX1 and roX2 non-coding RNAs, promoting recruitment to the male X chromosome. It also potentiates the histone acetyltransferase activity after chromatin binding.
Sequence:
MSEAELEQTPSAGHVQEQPIEEEHEPEQEPTDAYTIGGPPRTPVEDAAAELSASLDVSGSDQSAEQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSSTRSSSSSRYDDVSEAEEAPPEPEPEQPQQQQQEEKKEDGQDQVKSPGPVELEAQEPAQPQKQKEVVDQEIETEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAAPPPPPPPPAAEQVPETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTGDPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSPQTAAAVVRAPGNSG
The following text describes a protein:
Function:
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
Sequence:
MSSKPDTGSEISGPQRQEEQEQQIEQSSPTEANDRSIHDEVPKVKKRHEQNSGHKSRRNSAYSYYSPRSLSMTKSRESITPNGMDDVSISNVEHPRPTEPKIKRGPYLLKKTLSSLSMTSANSTHDDNKDHGYALNSSKTHNYTSTHNHHDGHHDHHHVQFFPNRKPSLAETLFKRFSGSNSHDGNKSGKESKVANLSLSTVNPAPANRKPSKDSTLSNHLADNVPSTLRRKVSSLVRGSSVHDINNGIADKQIRPKAVAQSENTLHSSDVPNSKRSHRKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDSVNSESADHTNNKSEKVTPEYNENIPENSNSDNKREATTPTIETPISCKPSLFRLDTNLEDVTDITKTVPPTAVNSTLNSTHGTETASPKTVIMPEGPRKSVSMADLSVAAAAPNGEFTSTSNDRSQWVAPQSWDVETKRKKTKPKGRSKSRRSSIDADELDPMSPGPPSKKDSRHHHDRKDNESMVTAGDSNSSFVDICKENVPNDSKTALDTKSVNRLKSNLAMSPPSIRYAPSNLDGDYDTSSTSSSLPSSSISSEDTSSCSDSSSYTNAYMEANREQDNKTPILNKTKSYTKKFTSSSVNMNSPDGAQSSGLLLQDEKDDEVECQLEHYYKDFSDLDPKRHYAIRIFNTDDTFTTLSCTPATTVEEIIPALKRKFNITAQGNFQISLKVGKLSKILRPTSKPILIERKLLLLNGYRKSDPLHIMGIEDLSFVFKFLFHPVTPSHFTPEQEQRIMRSEFVHVDLRNMDLTTPPIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNIRASKFPSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGDLSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPKLRALEIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNNFSDVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVLPQLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLAMVFTDIKSSTFLWELFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSGLTWCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKESLKEVYGEEIIGEVLEREIAMLESIGWAFFDFGEHKLKGLETKELVTIAYPKILASRHEFASEDEQSKLINETMLFRLRVISNRLESIMSALSGGFIELDSRTEGSYIKFNPKVENGIMQSISEKDALLFFDHVITRIESSVALLHLRQQRCSGLEICRNDKTSARSNIFNVVDELLQMVKNAKDLST
The following text describes a protein:
Function:
Conversion of folates to polyglutamate derivatives, including tetrahydrofolate. Required during embryogenesis; from maternal tissues until the globular stage, and from the embryo after the globular stage.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MRTLWNHFSTISYIKISPRMRRISAANLISNRNLSTISSTEDPELRDFVGFLESLKNYEKSGVPKGAGTDSDDGFDLGRMKRLMLRLRNPHYKYKVVHVAGTKGKGSTSAFLSNILRAGGYSVGCYSSPHILSIKERISCNGEPVSASTLNDLFYSVKPILEQSIQEENGSLSHFEILTGIAFSLFEKENVDIAVIEAGLGGARDATNVIESSNLAASVITTIGEEHMAALGGSLESIAEAKSGIIKHGRPVVLGGPFLPHIEGILRSKAASVSSSVILASNIGSSSSIKGIINKNGIGLCQSCDIVIQNEKDDQPIVELSDVNLRMLGHHQLQNAVTATCVSLCLRDQGCGRVTDEAIRIGLENTRLLGRSQFLTPKEAETLLLPGATVLLDGAHTKESARALKEMIKKDFPEKRLVFVVAMASDKDHVSFAKELLSGLKPEAVILTEADIGGGKIRSTESSVLKESWIKAADELGSRSMEASENKTVLGSLKLAYKILSDDTTSSDSGMVIVTGSLHIVSSVLASLQH
The following text describes a protein:
Function:
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
Sequence:
MARNKGGLRFQPSGGARGPAIPVGKKQRLTIERLAHDGRGIAHEAGMTWFVSGGLPGEELEARVLGARSKVVDARSERLFSSSDLRRREPCTVAGRCGGCTLQHLEHGEQLALKQRTLQEQLQRFAGIEPEEWAAPLVGPEFGYRRRARIAVRWDARARRLDVGFRASASQEIVAFDECLVLVPPLQTIARALPALLQDFRKPESIGHVELFHGTASALLLRHTTALVDEDRQRLAAFCSAHQAQLWLQGAEQPLPVEPAAELGYSLGDWQLTLAYRPGDFVQVNAPVNESMIRQALDWLAPTADERVLDLFCGLGNFSLPLARRVARVVGVEGVAAMVERAGANALANGLGNAHFFQADLSKALAEAPWAEQGFTAVLLDPPRDGAFEAVREMSSLGARRVVYVSCNPATLARDAGEMARQGYRLKRAGILDMFPQTAHVEAMALFEAG
The following text describes a protein:
Function:
Nuclear factor required for the production of piwi-interacting RNA (piRNA) precursors. Specifically required for piRNAs produced from loci associated with the Ruby motif. Promotes binding of the transcription factor snpc-4 at piRNA genomic clusters. Required for normal fertility.
Subcellular Localization:
Nucleus. Chromosome. Note=Concentrated in nuclear foci of pachytene germ cells. Colocalizes with snpc-4 in nuclear foci in a mutually dependent fashion.
Sequence:
MNRNRKGHDLENIEHRFTDEDLAGLKEQKLFNGKWIILEKKEKRGAAYCYLVCDKPCKKFGILYLEIGEDNVTTIANQVDFYHQQSSLGYSHRFSALIDAGIINNHVFFMVVRIRAGPTLHDLLKCLSSDKMSVTTASFLAVDMISAIEILSASGWVLRNFDSKQWMLDIKTRQFYLADATDITVSSDKRHRAIDEIHLRTAESIDLHWKTGDLIYAPRSFVDRDQSHRMTELDMMEMMLYVLYDWTHGKLPWKSSKSRERIMEMKELFIENLQKEPEETNKVEQQIDVDVWFDIALRNFAKHLKVAKEEQEKLEKLPVRGGAWCPKGPRAGAQISTVNYRGIIDDFYKIVCSGRPAWALHWRDVMLDWDRKLENTPETSKMFEAYEKHQRSLEISEEWERLQATREHYTVMKNHTETEMAKNQAAIVEYLMPEEEAKEEPIDKKKDPEEEAAAAVVGKKRRGRKPKKKDDPKMELKDEVKDLKDFVVEESTSASSSAPKKRPCCSSGSPLKSSGGRRRGCEIRRK
The following text describes a protein:
Function:
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Subcellular Localization:
Nucleus.
Sequence:
MANRWWAGNIAMNPMEEENKIESNRLGMRREQEFMNTTTTTNSSGSNNNQNPNELLLEGDHEGGGPSXXXXRRRLRGRPQGSKNKPKPPIVVTKETPNTLRSHVLEIKSGSDIVESIATFANRRGRGVPVGATGLTVYLAGSQGQVVGGNVVGELMASGPVMVIAATFTNATFERLPFEDEDEKEEDNANERMQMQLHTTSGVGNENSGSLQADDSMYNLPTNDLPNEQMTHEVFWAPPPSRHPPYN
The following text describes a protein:
Function:
Regulator of red blood cells formation.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MESNGASVQYNRWSEDNITLQEPQSRSRLLGIYNRVFTGRLVIMFKIAASLTVMVVMYIAGYITGFYVHQCG
The following text describes a protein:
Function:
Stabilizes specific chloroplast mRNAs. Required for normal chloroplast development under cold stress conditions by stabilizing transcripts of numerous mRNAs under these conditions.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSASASSLSAFNPKSLPLCVSRPASVSVLPPSLSFKLHSDHLVSIFASSALKCSSPAEYPSRFVRNVAVSSDFEVEEDDMFADGDDSAPVERNSFSPDLKLFVGNLSFNVDSAQLAQLFESAGNVEMVEVIYDKVTGRSRGFGFVTMSTAAEVEAAAQQFNGYEFEGRPLRVNAGPPPPKREESFSRGPRSGGYGSERGGGYGSERGGGYGSERGGGYGSERGGGYGSQRSGGGYGGSQRSSYGSGSGSGSGSGSGNRLYVGNLSWGVDDMALENLFNEQGKVVEARVIYDRDSGRSKGFGFVTLSSSQEVQKAINSLNGADLDGRQIRVSEAEARPPRGQF
The following text describes a protein:
Function:
Probable guanine nucleotide exchange factor (GEF).
Sequence:
MKPLEKFLKKQTSQLAGRTVAGGPGGGLGSCGGPGGGGGPGGGGGPAGGQRSLQRRQSVSRLLLPAFLREPPAEPGLEPPVPEEGGEPAGVAEEPGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTSPPWAPLGAPERPEHLLNRVLERLAGGATRDSAASDILLDDIVLTHSLFLPTEKFLQELHQYFVRAGGMEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ
The following text describes a protein:
Function:
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Membrane; Peripheral membrane protein.
Sequence:
MKKLWLVGSDKLYIGSRDETMRVWVANLDRLLYYAGVIKVGGEVGCMLSEGPCMFVGMPNLVKAWNLQTSAELSLNGPVGQVYSLVIGNDLLFAGTHDGSILAWKYNAASNCFEPAASLQGHTSAVVTLMAGDSSKDLERSYFDVLGLCCSSEVQLIDRILKPLEGVHHVSVIVHTRTVIFLHNVALISQLQIVKSLNWVWLEENVRMKGEQSCQNKWPSPFVVVCGLLLLLSFFKYVSSPFQWLALGVVVVDIIPEVLKAIASLRNLELDINILMLIAGKLHIHVIFKYAFSCSNHFLYAAGGSVFLKDYWEAGTIVFLLNISKWLETRASHRAAAVMSTLLSIAPQTVVLANTGEEVNTKEVMVNTRLAVKAGTMIPIDGVVVDGNRELEEKALIGESFPVSKQVDSNVRVGTVNLNGYITVKTTTLAEACVVAKMVKLVEEAQSNKSKTQRYVDKFAKYYTPGTISFCNSFVWNAKK
The following text describes a protein:
Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
Sequence:
MPSTSWRSHFLPSCSVGELQEIADGMTGFVLPADPANEVYPRVLLGDAPTALSTYKLNQLGVTHVVNVAQAPTISMYPPSDTLKHSKWQDWGAVGGFVRTSEAYYRHVGMEFLGIPAYDTFTFNLSRYFYEAACFIDEALRSGGIVLVHCHAGISRSATIVAAFLMIKRGMTAQEAIRVIRSRRSIRPNAGFMQQLCDLNETLLGERRRARADLVAAARNGNTSVAVL
The following text describes a protein:
Function:
Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTIKNNILVIGSGSREHAITWKLLESNQVDKVILVPGNASSSTMERVITVECSKIDAESISNICKEHNVEYVFVGPEVPLVDGIVDGLKRKGISCFGPTKKAAQLEGSKVFCKDFMARNNIPSARYQTFTDYNKAKQYIESLNYKIVLKASGCAAGKGVLIPNNKEEELEGLKRIMVDKEFGSAGDEIVIEEFLDGEECSLMCFSDGYSLVVMPPAQDHKRIFDGDKGANTGGMGAYAPAPFIVDCNNNATTDKSKSKSSFGTIIDRCVETILKPTINGMRKEGKPFVGVLFAGLMVSSSSSTTNDKVINVLEFNCRMGDPETQVVLPLLETDLFEIVLACIEGRLDGLDVKWSNKFAVTVVAASKGYPDSYPKGLKINGLLENKNTNDNIIFQAGTTVNGSNDIVTNGGRVLSCTSVSESLEDAIKNSYKLIETISFEGMQYRKDIGQKALNHLERKKQQQANSKQSVSYSESGVDIERGDAVVDNIGPLAKATTRLGCVSDLGGFGALFDTKAAGFRDPILVSGTDGVGTKLKIAQELGIHDSIGIDLVAMCVNDVVVQGAEPLFFLDYFATGRIHVDVATQVVSGIARGCKESGCALIGGETAEMPGMYKDGEYDLAGFSVGAVERDQMLPSNIQEGNILLGLASSGVHSNGYSLVRYLIETKSGGLTYNSIAPFDSSKTLGQVLLTPTKLYVLSCLAAIKSGGVNGLAHITGGGITENLPRVIPDGLDCEVELGSWEILPIFKYLVELGNMETEELLKTFNSGIGMILIVSPDKVDSITKSLESNNEKVYKIGKIINSKTSKQSKSKVIYK
The following text describes a protein:
Function:
May be involved in the acquisition of desiccation tolerance during late phase of embryogenesis.
Sequence:
MGNLKSLVLLALLFSFSVAVFANTSNDATHDEVKPSTEATHAIEAQKHDGKPQIAEAQVEANDPVVEPQQDWGGRGGCRWGCCGGWWRGRCRYCCRSQAEASEVVETVEPNDVEPQQGGRGGGGGGGGGRGGCRWGCCGGWWRGRCRYCCRSQAEASEVVETVEPNDVEPQQGGRGGGGGGGGGRGGCRWGCCGGWWRGRCRYCCRSQAEASEVVETVEPNDVEPQQGGRGGGGGGGGGRGGCRWGCCGGWWRGRCRYCCRSQAEANEVVETVEAQQAKP