lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Sequence:
MEERTRAYLRGRFGDVYRRAEIDLPPRADDREWGYIPWTAGPDTTMVRHKSTLDLGSMTSFLERKCPRHVYFSAGTYDAPGAATMDEKHWQGSDLVFDLDADHLPRVTLGEDSYAEMLSKCKDALLRLLDFLERDFGFEELTVTFSGGRGYHVHVRDAGVYELGSEERREIVDYVRGNDLALETLVEAEPVGGRGLENPTEKRMLPADGGWGRRVTTRLEAFADDLIERGEDDAVATLTEFDGVGERSARAIYNVVADNTTAVKRGNVDVHPAFLTVARRYIDETVAAEQAPIDEPVTTDTNRLIRLPGSLHGGSGLEVQRLDRAALDDFDPLVDAVPETFVGHDITVELPTEHTVELRGESLTVGPGVSTVPEYAGVFMMARGTAEKATE
The following text describes a protein:
Function:
Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The CXXC zinc finger mediates binding to CpG-DNA.
Sequence:
MHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLKCGAAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLADCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQICKFRKCEELKKKPGTSLERTPVPSAEAFRWFF
The following text describes a protein:
Function:
Involved in olefin biosynthesis. Catalyzes the elimination of carbon dioxide from beta-lactones to form the final olefin product.
Subcellular Localization:
Cytoplasm.
Sequence:
MTYPGYSFTPKRLDVRPGIAMSYLDEGPSDGEVVVMLHGNPSWGYLWRHLVSGLSDRYRCIVPDHIGMGLSDKPDDAPDAQPRYDYTLQSRVDDLDRLLQHLGITGPITLAVHDWGGMIGFGWALSHHAQVKRLVITNTAAFPLPPEKPMPWQIAMGRHWRLGEWFIRTFNAFSSGASWLGVSRRMPAAVRRAYVAPYDNWKNRISTIRFMQDIPLSPADQAWSLLERSAQALPSFADRPAFIAWGLRDICFDKHFLAGFRRALPQAEVMAFDDANHYVLEDKHEVLVPAIRAFLERNPL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Sequence:
MEAAPASVTAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLRGAGRGRRRGPRPRAGPATAGRPAAAAAPAAPATPAATPRARGAAGGRPRGPRLLRTPEAAGGRAPRPAGRRRGGGRGGGRGGGRGGGRGGGRGGGGRRGRRAGPRGRRGPPPAPAPRPRRAGRPGPPGGARRGGPGPPPRAAGRPGRPAARRPAPARPGPPGPPRARGSGGGGVPGPPRPGGRGRAGVPLPLRQGLLAQEHAGPPRQHAPRPAALRLPRLRQEVQDEAPPHRAHEDAHGPQALPVPRLRQEVHVARQLHAPPRPLRAPPPARGPPRPPRPRPAPLAAAAPAAAAPGRRRPPPRAGLQRGRRELRAAGPPPPAPALPPSRPARARTRGGGGRPGAPRHGRAPARTLSLTRGDTTPPPPRHAPTLAGTRGRTDTSPTRTRALSDTRTHGDAPPPTRRHARRDTWTRRHAP
The following text describes a protein:
Function:
Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MSLGEDEAETKVSVNTEVPSCGRWDSGNLLSPGQEPEHLEVQGGPQWRAEADPGCISGVFLSQTYTASKEPVAGRSEPPLSGPLPSASVGTGELLHPMGSQMEENKPPASRDLLPAIKVLGTITVCSGREADSEDFQPAVAPSQVLGLGQQPHISGLPLLSQWKPTVSPGAPQLSSRSISVSSVGSSLQDHLDKAEPQSGSFAHISSQELTVPQAAHSVVGAGSPFQWSTQPVASGGDATGLGKRHLSFQAEYWACVLPNSLPPSPNRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKQLESHVLADPVMQDSGVDLDSFSVSPASTLKSPTNVSHNCSSAEVPTLPLSGAREPCLERWPLGVSQKQGGASLASWNQLASTPRTPGTEGASWENREAALRGTTEDYLPRGKNASAGSPQLKTKEKGPPFPRGEREKTGRQSAGCPACVKPEWPSEEEIGSDEEYLALPSRLTQVSSLVSYSGARPTYVNPPTGAAEGHRSLQVSDSDEPASPTLDSSQRQHPSGTTFQGPVGQSPCFGHSVQPQDSRGKSRLMSSQTLGVSAKQLKTHPSSKAVSDKWLLSEPVAGEKLPRRIEEQEKASLLQCVQTFCCQLEELICWLYNVTDVADLSAPPRASLTGLKSSLQLYRQFKKDIDEHQSLTESVLEKGEILLQCLLDNTPVLKDVLVRIAEQSGELESRADHLYDSILASLDKLAGCTLIPDNKPRAAAEHLHEGP
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKARGKALGSQAGVQRAKPPANSNPFEVKINRQKFHILGRKTRHDVGLPGISRAKAIKKRTQTLLKEYKERDKSNVFTDKRFGEYNTKISPEEKMMKRFALERQRNNEKKSIYNLNEDEELTHYGQSLADIEKFNDIVDSDSDTEERGMLSAELTASHFGGGGGLLRKKTSEPGEEEEKPKSRKELIEELIAKSKQEKRERQTQRENALELTEKLDSDWKEIQFLLSHKTPKSEKKDKEEKPKPDTYDIMVRELGFEMKAQPSDRMKTEEELAKEEQARLKKLEADRLRRMLGKEDDEKSKKPKHISADDLNDGFVLDKDDRRLLSYKDGKINQEIDDPNEEGKAQEEDSEGEEDQQPDTEDSEESDDPDNHSDLESNEASEEEDIETENQKKKHIHAPEKNPSGGNQKAMIEAARSELPYTFAAPDSYEELKSLLSGKSTEQQLVVIERIQKCNHPSLAVGNKAKLQKLFGFLLEYIGDLATMTPPDLKTIDKLIVQLYNLCQMFPEFASSSVKFVLRDVVHEMEEMIEIKGRAAFPGLDVLIYLKIIGILFPTSDFWHPVVTPALVCMSQILTKCPVMSLQDVIKGLFVCCLFLEYVSLSQRFVPELINVLAGVLHMATPNKATRGYTLVHPFKPLGKNSELLLVSEKEDMDTWSKKGLPLSKVNGLKEGSKSETNHIRLSCICVCLNLIKRCLAMYNTLPSLPEIMEPIRVLLTDHIPECGYPRELQELSQSILQEMGNREETYQPLVCEKSKPVPLKMFTPKLVKVLEFGRKQGSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDSERKRKVKQLFGSLATQEGEWKALKRKKFKK
The following text describes a protein:
Function:
Binds the 23S rRNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAVSLPNSFLQISPCVPSLQLRKPVMAAVKGGKQSVRRSSNTVVQITCRKKELHPEFHEDAKVYCNGELVMTTGGTKKEYVVDVWSGNHPFYLGNRSALMVDADQVEKFRKRFAGLSEIMEIPVLKGEIIMPTKKSKGPKGKKK
The following text describes a protein:
Function:
Esterase; part of the gene cluster that mediates the biosynthesis of asperlin, a polyketide showing anti-inflammatory, antitumor and antibiotic activities. The first step of the asperlin biosynthesis is the production of the intermediate 2,4,6-octatrienoic acid by the highly redusing polyketide synthase alnA with cleavage of the PKS product by the esterase alnB. 2,4,6-octatrienoic acid is further converted to asperlin via several steps involving the remaining enzymes from the cluster.
Sequence:
MPKILCLHGYGTSASILQHQLGPFMAAADPSYEFVFLEGEIECQKAQGLGPFVKGPFLCYNESFAPADIQESCDLIDEMIQAAGPFDGIIGFSQGGSVALSYLLQRQIDGHPPPFRWAVFFSTVIAFAPNDTFGSNILANLTDHEIRLLDGYPATDLSSLHPLTRALCETTAQTFYSAKTGGFISPNTPIAEFSKRDDPSQPRVFHPALLGDRIPIPTVHITGRKDNSLMVGLSVLVQGLCDQRLIRSLTHSGGHNVPRSADDVRAAWAAVDWAIQHSQKQHIW
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities. Component of the ADA histone acetyltransferase complex, which preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B. May be involved in response to DNA damage by genotoxic agents.
Miscellaneous:
MISCELLANEOUS: Present with 2470 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPRHGRRGKLPKGEKLPKKEGGDNTPSKLLSSMLKTLDLTFERDIGMLNGKSVRSIPNKKTLLELQSQLDSLNEILGTIARGDQETIEALRKIRDSKNEKQANDEKQETSNADGQHESSTATEETNIIDKGVQSPPKPPPSNEISGTIENDVESIKQAADNMAKEEINEDKDLQVHRDQPREKRPFDSETENRATENENTQRPDNKKQKIDVDKMENDPTVKNPKSEFVVSQTLPRAAAALGLFNEEGLESTGEDFLKKKYNVASYPTNDLKDLLPGELPDMDFSHPKPTNQIQFNTFLAFVENFFKDLSDDNLKFLKMKYIIPDSLQFDKTYDPEVNPFIIPKLGPLYTDVWFKDENDKNSAYKKPSPYSNDASTILPKKSANELDDNALESGSISCGPLLSRLLSAVLKDDNDKSELQSSKIIRDGGLPRTGGEDDIQSFRNNNNDTVDMTLSQENGPSVQTPDNDIDEEASFQAKLAENKGSNGGTTSTLPQQIGWITNGINLDYPTFEERLKRELKYVGIYMNLPKDENNPNSDDPDWVTGREDDEISAELRELQGTLKQVTKKNQKRKAQLIPLVERQLAWQEYSSILEDLDKQIDQAYVKRIRVPKKRKKHHTAASNNVNTGTTSQIAQQKAANSSLKSLLDKRQRWINKIGPLFDKPEIMKRIPNESVFKDMDQEEDEDEADVFAQNTNKDVELN
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLSFRSLTSTFGFVSRFQIRRLGTSLSIQNLEVQDGRWKGKLATEKKTNREHKSVDTNIKTMKMLKNPKNSTRYLRRSFVPNHRKQENGRDILEDSLSKDHLKVKSCITITTGEGYDLKRCMKLLTMQGLQPTNLIPDEIVSFSYQDNGNKGDVMILGQNGSIVSWGFSESSVRNCIVPIVKAASLNPLNGEDFETEDMDYVEIEGEQDFDKLSSLDNKVTPRIACESFLSGDLIIINSLDSDQGMLDKAAFSSGLSRSTNLAVLEEAMEKHISKTRTITENISKGTKLNLRSSDALKSIGRLFLIRGKLNLYSELIETPDLYWSEPQLEEIFKNVSRYLDIGPRINILNSKLDYSTDECRALISLLNERNSTFLEWIIIYLIAFELCFEIYHFYQKYSSYCSEPTNDDLDATK
The following text describes a protein:
Function:
A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNLSLRRSTSALLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAITLVNNVTLVVLFFALINCAYSVFATVLKAWFADNLSSTSKTKIFSINYTMLNIGWTIGPPLGTLLVMQSINLPFWLAAICSAFPMLFIQIWVKRSEKIIATETGSVWSPKVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVIADGDFAEKVVAVVLPVNAAMVVTLQYSVGRRLNPANIRALMTAGTLCFVIGLVGFIFSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPEMKASYFSAQSLGWLGAAINPLVSGVVLTSLPPSSLFVILALVIIAAWVLMLKGIRARPWGQPALC
The following text describes a protein:
Function:
Chaperone involved in the folding of extracytoplasmic proteins.
Subcellular Localization:
Periplasm.
Sequence:
MKMKKFVLRSFLLATLGCVAFTSMAQAEERVVATVDGIPVLESQVRANMGKKGDRQSAIDKIIDDILVQKAVQESGVKIDPREIDHIVEDTAARNGLTYGQFLDALDYQGISLNTFRQQIANQMVMGAVRNKAIQESIDVTREEVVALGQKMLDEAKSQGTAQKVTGKEYEVRHILLKLNPLLNDAQAKKQLAKIRSDIIAGKTTFADAALKYSKDYLSGANGGSLGYAFPETYAPQFAQTVVKSKQGVISAPFKTEFGWHILEVTGVRDGDLTAEAYTQKAYERLVNTQLQDATNDWVKALRKRANIQYFNK
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVAVAYFNSKRHHVVLLDSPGHKDFVPNMIAGATQADAAILVIDASVGAFEAGFDNLKGQTREHARVLRGFGVEQVIVAINKMDIVGYSKERFDLIKQHVGSFLQSCRFKDSSLTWIPLSAMENQNLVAAPSDNRLSSWYQGPCLLDAVDSVKSPDRDVSKPLLMPICDAVRSTSQGQVSACGKLEAGAVRPGSKVMVMPSGDQGTIRSLERDSQACTIARAGDNVALALQGIDANQVMAGDVLCHPDFPVSVATHLELMVLVLEGATPILLGSQLEFHVHHAKEAATVVKLVAMLDPKTGQPTKKSPRCLTAKQSAMLEVSLQNPVCVETFSESRALGRVFLRSSGRTVAMGKVTRIIQDS
The following text describes a protein:
Function:
Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.
Sequence:
MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSIQFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQKWRKSQKEE
The following text describes a protein:
Function:
Regulates tillering and panicle branching by modulating SPL14/IPA1 transcriptional activity on the downstream TB1 and DEP1 target genes. Binds directly to the 5'-T/GCTCTAC-3' DNA motif found in the promoter regions of both TB1 and DEP1. Represses the DNA binding activity of SPL14/IPA1 toward the promoters of both TB1 and DEP1. Exhibits weak transcriptional activation activity in yeast cells.
Subcellular Localization:
Nucleus.
Sequence:
MAGFPLGGGSHSRDNPAPPVPPVHPADAASFLYATRGGSFQLWQQQEQQPFYASNIIRFADDAPPAPSLAGASSSSSSRGMRSSGGGGGGGGGGISCQDCGNQAKKDCTHMRCRTCCKSRGFACATHVKSTWVPAAKRRERQQQLAALAASAAATAGGAGPSRDPTKRPRARPSATTPTTSSGDQQMVTVAERFPREVSSEAVFRCVRLGPVDQAEAEVAYQTAVSIGGHVFKGILHDVGPEALAVAGGGGASEYHFRLTGDGSSPSTAAAGEAGSGGGGNIIVSSAVVMDPYPTPGPYGAFPAGTPFFHGHPRP
The following text describes a protein:
Function:
Exhibits apurinic/apyrimidinic (AP) endonuclease activity in vitro. By contrast, another report show that APE2 has no biochemical activity. Unable to catalyze the conversion of 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) to 3'-OH. Has no in vitro 3'-phosphatase activity. Redundant with APE1L and at least one functional allele is required for seed viability. Has a strong non-specific affinity to DNA.
Subcellular Localization:
Nucleus.
Sequence:
MKIVTYNVNGLRQRVSQFDSLLKLLDSFDADIICFQETKLRRQELTADLAIADGYESFFSCTRTSEKGRTGYSGVATFCRVKSASSSCETALPVTAEEGITGLVNSNSRGGKSETSTVAEGLEEYEKEELLMIDQEGRCVITDHGHFVVFNVYGPRAVADDADRIEFKHRFYGVLERRWECLLRQGRRVFVVGDLNIAPFAMDRCEAGPDFEKNEFRKWFRSLLVERGGSFSDVFRSKHPERKDAFTCWSSSSGAEQFNYGSRIDHILVAGSCLHQDEDKQGHSFLACHVKECDILTEYKRFKNENMPTRWKGGLVTKFKGSDHVPVFISFDDLPDIPEHSTPPLASRYLPMIYGFQQTLVSVFKKRRANEEAKAIEVSCSSSTQSNTSSICGDISTGPLRNCGSMGISLEKSCSFENKSTSGVTEAETVAATGSIDNLSDGIRASSVRALNISRDGDRKKARKIQSSQLSLKSFFTTNSKVNNVEDSSSSYVSSSPSSQVESITEPNVSGKEDSEPTTSTQEQDQTGSSAKQKNDAALMEWQRIQNLMQNSIPLCKGHKEACVARVVKKPGPTFGRRFYVCSRAEKQTVVISNGLHQNSETSKRVMRSK
The following text describes a protein:
Function:
Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the endocyclic-delta(4),delta(8)-7R-dihydro-hydroxyphenylpyruvate (en-H2HPP) to generate a mixture of 3E,7R- and 3Z, 7R-olefins of the exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP).
Subcellular Localization:
Cytoplasm.
Sequence:
MKTKQDLQELYFPTPKLIEWENGVRQYSSVRGDTEVLLSYVPPHTNVEPHQHKEVQIGLVVSGELSMTVGDVTRKMTALESAYIAPPYVPHGARNETDQEVIAIDIKRLKAGETYTSPEDYFLNIFKTRDLLPGMEVTFFVEDWVEIMLANIPGNGGEMPFHKHRNEQIGICIGGGYDMTIEGCKVDMTFGTAYFCDPREDHGAINRFEKDSKSVNIFFPPRYNRAKAKKLEAKES
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSVATTALMILMTKWAANTASATGEPLLGKTWKPPCAIAKELRKVPVMAYTHESNLQDAITAAERTAAKLNLYAATTQSDVETTALLSAAAAAIYEEADASERQRSNFIKTALEATATTQELTGGIEASLQVFKSAKHSGGYCLADTDTDEDKTADIATAGCEQRPKTMKKTPSETLDADIISATGFKTIDEITGTNGMATSVSTKCGLVNFAGAGTGAFVTGATAVNFGYGLFKIATTNRVTRTSQQNLKKQTNRDADDLLTLAFNDADTIRAAITQQLAHEPEAIIKAAVTTGKLKGHLTKLLHKLYGKQAGKQAEDKAEVLIKENFGEAGEKVKSFLNKLDEADAINVDPSATTNTKIKEINDAGILQVTLAFYKILEVKHKQQMADQVAKLQAQATEKQQDVKSAEQTCNDLKEKSDCDTNNRCTYDKTKEDGKKCTLSDEEKEAAQKEGGEKDSKTGNTNTTGSNSFVINKAPLLLAFLLF
The following text describes a protein:
Function:
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity). Aminopeptidase that binds to the auxin transport inhibitor N-1-naphthylphthalamic acid (NPA). May play a negative role in the regulation of PIN auxin transport proteins.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MSEILSSLRSLMASHSPPLDALVVPSEDYHQSEYVSARDKRREFVSGFSGSAGLALITKKEARLWTDGRYFLQALQQLSDEWTLMRMGEDPLVEVWMSDNLPEEANIGVDSWCVSVDTANRWGKSFAKKNQKLITTTTDLVDEVWKSRPPSEMSPVVVHPLEFAGRSVSHKFEDLRAKLKQEGARGLVIAALDEVAWLYNIRGTDVAYCPVVHAFAILTTDSAFLYVDKKKVSDEANSYFNGLGVEVREYTDVISDVALLASDRLISSFASKTVQHEAAKDMEIDSDQPDRLWVDPASCCYALYSKLDAEKVLLQPSPISLSKALKNPVELEGIKNAHVRDGAAVVQYLVWLDNQMQELYGASGYFLEAEASKKKPSETSKLTEVTVSDKLESLRASKEHFRGLSFPTISSVGSNAAVIHYSPEPEACAEMDPDKIYLCDSGAQYLDGTTDITRTVHFGKPSAHEKECYTAVFKGHVALGNARFPKGTNGYTLDILARAPLWKYGLDYRHGTGHGVGSYLCVHEGPHQVSFRPSARNVPLQATMTVTDEPGYYEDGNFGIRLENVLVVNDAETEFNFGDKGYLQFEHITWAPYQVKLIDLDELTREEIDWLNTYHSKCKDILAPFMNQTEMEWLKKATEPVSVSA
The following text describes a protein:
Function:
RNA-binding protein involved in RNA processing. Acts as a regulator of mRNA stability: binds to mRNAs and pre-mRNAs, preventing their degradation. Involved in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTTLLETPGYSEKLHDSIEKKLSEYGWGEEAASLADFVLVMLSNGKTQTEINEELVDLIGSDFDTSFSLWLFNQIEELEKSKNASVESVSKIDEIDFIEKESTDKSQQSFSVPETSIQPQSSQTPNITSLREEKELPTGRVGQKLKLTSQKQRFNPMAASFNYSKSVMPAAKRALTQTQEVPLCKYADKCSRANCIFAHPTPAAAPGEGMVLSSEMCASGKECKAADCVKGHPSPATVTTLPPFMSMSTIPIPCKYKPCLNPACRFIHPTKSRNMTWRPPSKTEETSLSERSFAVNESEEQLHVPSV
The following text describes a protein:
Function:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Melanosome. Note=Colocalizes with PMEL in stage I and II melanosomes.
Sequence:
MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
The following text describes a protein:
Function:
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSFQLSGSYKKKQNWEPKNKTTKHKTTTETSAEMKMKGEIGDMNLWREADFALNCTYIVNDQPSDQSTGIPRAITSIPRNLTFKYGRDNEVIGVFSKEYIPQGTRFGPLLGEVYTKDDVPKHANRKYFWRIYTGGHLQHFVDGYDLQKSNWMRYVNPAHSLHDQNLVACQNGKDVYFYTIKPVPPHSELLVWYSREFADRLHYPSPGDLLFSKHGHITKGIRDSPSESQKDQLPHKDKTFEEHQNAEAKETKREEERRDKMEKEMEEDERIDVEVLDRDTPPVTPDNQIVDFSKKLYESHAKKDTYAPAEPSYSPSHSLHGDTQDQRAEVPRKPMGPYCCSTDTPTSSQKEIPLHLHGLYTHREGLVSYPTYPPTRHLQQPCLYPYSSHYPRFVLPQYPPPFPSVLSRVPSAYSGYLSSDGLPYPLVSQPSLLPVSIPFQAQAGKEGLIVPSPPTAFSLTSPGAGGLKERPPNNSPPSGAPATPEHSPLPKLSSPRTSEREEAINLSTPKNSQATTVLGYKSLPYPLKKQNGKIKYECNVCLKTFGQLSNLKVHLRVHSGERPFQCMVCKKSFTQLAHLQKHNLVHTGEKPHECQVCQKRFSSTSNLKTHLRLHSGEKPYQCKLCSTKFTQYIHLKLHKRLHSREHPYKCHLCSRAFVHQFTLHIHTRGYCPSVAMAGQSMEELSRMNELIDKFDMSADADTLEERASLAEVDAVVQKWIIKNMEKKEGKEDQVEVCFLKKESLHAASFQERDTVVHMYRPPAHLPLTVKQELQ
The following text describes a protein:
Function:
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFASTWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQITYRDGRVAGAVHVGLLVGAVGLLGAALQRLPGRSWPVAATATATWAALGGTSLARTGRQISDLLERDDVEAARRLLPSLCGRDPAQLGGPGLTRAALESVAENTADAQVVPLLWAASSGVPAVLGYRAINTLDSMIGYRSPRYLRFGWAAARLDDWANYVGARATAVLVVICAPVVGGSPRGAVRAWRRDAARHPSPNAGVVEAAFAGALDVRLGGPTRYHHELQIRPTLGDGRSPKVADLRRAVVLSRVVQAGAAVLAVMLVYRRRP
The following text describes a protein:
Function:
Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.
Subcellular Localization:
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Preautophagosomal structure.
Sequence:
MSSTHSNNVGHPQSSPQGPLTEQQRAQQQYQIFENSLPKVSQSVYQMLLNEMVPLAMGIERQISGDVISSDSNVTSENGNINNMIKRLKIEEHHTVDIIRSHNLIHELYKADEEEKEKVLARLRNIGFQIGLKLSELLIFSNNPNLKFKEMDLLLIMKFICRDVWKQIFGKQIDNLKTNHRGTFYLLDYDYRPIQSFSLEEDAKNEELKMIEPFLEIPVGIIRGVLSSLGYSSEEVICLASFIDRPTDRPKTAFPKGVSFHVQVTMPQ
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMETENQQIGNQIKPKTTILCSICDLAFTPSEQKTLICTNCIINQTDITVGITKEGIVNYCRFCHRYLRPPWTLCERESKELLSICLKRLRGLNKVKIIDAAFVYTEPSSKRIKVKLTIQKEVLNNTNMQQTFICEFVEHYQQCEDCKKEFTPHTWGAAVQVRQRVDHKKTFFYLEQLLLKYNANDKVLKIEQVDDGLDFFYKSRSHANRLVEYLSTILPIRVKQSKQLVSHDASSNLFNYKYVYAVDLPKVCKDDLVILPQKLCKELGGVGRVQLCYKLTTIIYPLKLFLCMKMKLKSITLKTHQHEFTVVDVERIHTRNLNESYISITIIRESNNYVPVTVKSHLGDILKTGQVAIGYDLTQLTIESLEDISNYPECILVKRQINKEARKLRIFKLKRLEAQNVMEEEGGERKRNQQKKQNDQEEQFEEFLDDVEKDKEMRKNINLYRDEDKIKKLSKEDLKKKQKKQVQQQKKDNDDEWQDDDEDDVKLEDLMKDLNLEDKPELAEPVDEAQDEINQFITKLEKVTIEK