lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MNNNSNSSHNNNIDDNSNSNGGHTVVSPPKKKAQSKANESPKNPNSNPPPKKLKTKGSIQSNSPQSNTSAPLITDYFQVIPKIPSEFSDGTRNNTTSSSNTSLISQSTPNETPSSPNTSTPKTTTHLDFNHASSPITNSPKTTTTTTTTTTTTTATTAVTTSPVANTNTNISNNNNNIILKRTKKKSKDKKDGDNDKKKSTKKIEKSKVDKSTTKPKEKKKKDKEKEKEKEEKEKEKEKEKEKEKEKEKEKAKKKGKKKTDQKEPEEKNFETLLFSSNAILNNIEIGSFNSDDKNSYEELVLDESDNDGEIFAYTTTTIAINSPNKNITPKKRQFDELNTQPSQSDDTETTKSSKPKLYTTNTTTTSSPTKVSPNKTNISNTPSTRTITQEVIDINDNDEDNVNNSNSQNTFVDLVSDDSSDIEIAGVKRKNSNLEEFSIRSIESESILIPSDDEIELYEPNKNKANTSINMNNINNSATIPINNSFEINKEKVVNTNNILNEINSINDKSDSENSEINSDSKTQNNSIKRNNNSPKKPTELEIDSETTTTLNNNDKNNSFNNSNSYNINNIIKNIEMESRKETEVVKGVEEMEEMENQMNIQYGNEMNMDINKYKTNINSKQSLEIYQKPPKIDKSAIIKSINSIFLGAIQKISDLLGNFQINVNKDDGCFINIDSEALDEPIQIPFNHSITAIVKKHHGSHFRNPSFHKNLQTTLESLRDDRCEWATIVRDTKEVIEQCTVCREISNLTTASALRGTGKTVDAIDESEATDQEIDSEDEDNISNEEDEEDDEEESNEEEKEEDDEEEEENYRASKKKKNITNQRSHLKKKKFNEFEMVDLFASKECNYSLSQQYKFMKSLKQVDGIRRLKYTEYIQIYSEMRANIPDPKVLKQYTSFSQEVYGEANPKLIRQWIRLGLVKPSDVFCDIGCGIGNVLFQVASMVGCRVIGFEIRKDLFEISQKMLNTYRQCSKELGLHESTQNIEFYNCDIKGQLDFDFSKVNVFFMHNTCFPPDLELYIMELFKKHSSNDTKVLTMKTLCPRFKPSDKIRKPWGIFKYPYESYEMAEGSLSWKSAYKCSFYSFTIDDKDNFTNTDPSKLQINSIDHLQLIKSRKEKIVEDPFVDSDEETFIDKNNKNNKNNNNTYKIVNEEEIDKDNTEHKKKRPEKQQKSPKKRKIQTIIHNINIDDIDINEEISEDEENVITFDINLNNYRNKSNTEKEKEKEREKEKEKDNIGNELEFNFTVPNTTTSMLTLNSSPNSPSSANTTAPSTPISSTPKSKLATDLIPGFRIEKTFATPPLTRSSASTETNRLVQGCYKSLISYVLPKEEVELHKKQLQEQLLDHQRKLEQKHIQHQLLLQQRQVTQQLQKNLKKNDK
The following text describes a protein:
Function:
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown; Probable methyltransferase required to silence rDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFAEEEWNDEPTALVLTQAVFHHRQLSDFKSVTGVGNKKSLLRTLQTLGSVPDWNSPCKEGSSDGETDKAPQAAKKKRVRKNYKTAKTEVKDNEEDEGPVEKKRKAWPQKGGELRAQRDRQGSNKEAEMIRQGECETEQLKKDEGQSKVSRKQWKNKMKNKRKCKNKYRQNGQVSTALVVRKDGSGSLERSTVESKTTHSSLQVSQRQEQNKRGEGPGKKEPKGSAAKKVAFRSVEGSGLKSQPDGEEIETSGLWAISARKRKKDPKQQQAKLQKILKVLESKKTGSSVSQKEEKVADSPVPALDRSSALRARMEQRLESARFRYINEQLYTSTSQEAYRMFQQDRQAFNIYHQGFKAQVERWPNNPVDSIISYIRNKPSSMVVADFGCGDCKIAHSVKNKVHSFDLLPISDLVTVCDMAHVPLPDGSVDIAIFCLSLMGTNIGDFVVEANRVLVKSGILMIAEVASRFENVRSFLSALSTLGFKLATKDTSNCYFYTFELIKTKESEGKSHTAGLELKPCMYKKR
The following text describes a protein:
Function:
Acyltransferase; part of the siderophore biosynthetic pathway. Aspergillus fumigatus produces 4 types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage. TAFC consists of 3 N(2)-acetyl-N(5)-anhydromevalonyl-N(5)-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N(5)-acetyl-N(5)-hydroxyornithine)x3. The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA. Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split. For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N(5)-hydroxyornithine. The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively. The acetylation of N(5)-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL. FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation. Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively. Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC. Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MRNTICRLPNGQSYTVTPVFGGVNFKSNDMHLKDSIIPPGWTIVLYTNQNTDQPAQDSVPPEEERGRSRYTQGEAEEKTRTTRFTTPTLNDDCFYISFIVNPPSTDFKPPVSPTRQIAMMIWVSLYWYFHEPEPDLHLQTDAASQTPLTGKPKGEWRIHLKREGIFKGRNLLQKLERMGLIASEESSVGLEPSETQESGAWSRMFVSRRSFWQIDPRIFVFTLVPANPLHSAPSSPFISPRFASPSRESPIPTESPASPTGKDFPLHMPNEGPFASSSHLPTYFPPPPTQYTFTNGLRHPVRPKPPHQGEVFYIRFIPSVGQYLSFRVPILSSSATPSRGHGHSHSTSSIEVPPQTTPSDLDLLHKWMNDPRVSAAWGEGGPKEKQEKFLRNNLTSRHSFPVIGCWDGKPFGYFEIYWVKEDRLGALIGGADNYDRGIHLLVGEQEYRGSHRVAIWLSALVHYCWLADPRTQTVMLEPRVDNEK
The following text describes a protein:
Function:
Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases. May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase. Binds IGF2 RNA and promotes the production of IGF2 protein.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates from the cytosol to plasma membrane after UV irradiation.
Sequence:
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHVPPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDSAYFPGSSTSSSSDNDEGSGGATNHISGNKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSGSQLAEGKGSQMGTVQPIPCLLSMPTRNHMDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAALLYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPVIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQSVLEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRGRGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMNGSTGDARAPSHSESALNNDSKTCNTNPHLNALSTDSACRREAALEAAVLNKEE
The following text describes a protein:
Function:
Plays a role in sister chromatid separation.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein. Note=Targeting to the inner nuclear membrane requires the SRP1 and KAP95 karyopherins and the Ran cycle.
Sequence:
MNSDLEYLEDGFDPNSMKVATLRRILVENNVDFPSNARKNALVGLFDEKVKPQIPQLRKMYLNVRPSDEGIVKMDRPSSSPSIASPRRSRRARREKSASPMAKQFKKNRILDDVSNDDDDDDDDDDDNDKKDDPLIVPSGTDTDEVDDEEDDVITSSSNKSDTNDFQQNSDTRKKRKDPDSDDWSESNSKENKIDNKHLNLLSSDSEIEQDYQKAKKRKTSDLNQEHGNGSAILGKLSVKTPIKNTNRKPVSMDNFNDSLTSSGTENDPFVPNIRHNPKELGTANGTGHSTPLSKLKVSASFADKLPQKEVPSTILVPEVEQQEPSQSERTPSLFSSEGSGSESEAPLLPEITTPGPHQPMGNTSNNVVEMIDTDSSNLVSDEDEVLVPTRIETPQLPTEKDVEKCEARVQELQEEVNEQLEHENGSEFDVKQGSGKVGNRHKFKRALKFLSKSLLALFLFCIFIVIPLLFGLWYREQRLLIGYCGHEVPSHRVSGNSFEFIQKLDNLLQDYRPKCIPCPPNGICYPYLKLKCKPDYKLAPSRLDFLEIIPAQGKCVKDDKKQQLVSEVVEKSLEFLRAKNAQISCGDGKDDIESGMTEDALYQIFNEARAPWIRDDEFEDLWIQVIKDLTEEPEILWRQLSPTDNNIGGNSNNIIKTNDVPRQKRHLPEKFISKTRNFRSTSKKYIGMKCRFEREIYQTYKKFQRPIWLMFLLIVISKVIEIKLKNYYRKKARIEELVTQTMEKLKFQKIKSMSDPKENAYLSIVQLRDIFLSDIVDLKYKNQLWSEVVKYLEHNNSNIKSNLTEIRGEIMKCWEWIGPMELNEPKDSAENKI
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their own transcription. There are 3 operators to which MazE binds. MazE has higher affinity for promoter DNA in the presence of MazF; Cell death governed by the MazE-MazF and DinJ-YafQ TA systems seems to play a role in biofilm formation, while MazE-MazF is also implicated in cell death in liquid media; Might also serve to protect cells against bacteriophage; in the presence of MazE-MazF fewer P1 phage are produced than in a disrupted strain. For strain K38 most wild-type cells are killed but not by phage lysis; it was suggested that MazE-MazF causes P1 phage exclusion from the bacterial population. This phenomenon is strain dependent.
Sequence:
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKEVW
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Sequence:
MFARTALRATASASPIARVSASAAPVAAASRFFSSSPARLVKIGELLPEGELLQEGSPGNKVDLRKEAESARNMLIIGVPAAFSPACSASHIPSYIQHPKTQEFDVKAVVSVNDAFVMKAWKENLDPAGESGIRFLADPSGSFTKALDLTFDSKAIFGNDRSKRYAMIVEDGKVTKIAVEPDNTGTAVSLADKVLG
The following text describes a protein:
Function:
Binds fatty acids in a 1:1 molar ratio.
Sequence:
MALSGVFGKKYKLEKSDKFDEYMKALGVGLVTRKMGNAVSPVVELTKNDDEYTLSSSSTFKNVVLKFKPGVEFDQETPDGRKVKATITVDGNTLHEVQKDPSSGKETVIDRTFTDDEVKMVMSVDNITATRIYKIQA
The following text describes a protein:
Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
MSYPGYPPTGYPPFPGYPPAGQESSFPPSGQYPYPSGFPPMGGGAYPQVPSSGYPGAGGYPAPGGYPAPGGYPGAPQPGGAPSYPGVPPGQGFGVPPGGAGFSGYPQPPSQSYGGGPAQVPLPGGFPGGQMPSQYPGGQPTYPSQINTESFPSYPVFSPVSLDYSSEPAAMTQGTQGTIRPAANFDAMRDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILALFMPPTYYDAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDENQSVNHQMAQEDAQRLYQAGEGRLGTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTILQCALNRPAFFAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAIVGQ
The following text describes a protein:
Function:
Transcription factor. Specifies differentiation of the set of six touch receptor neurons (TRNs). May positively modulate expression of both its own gene and also of homeobox ARX homolog alr-1 in TRNs, forming a positive feedback loop with alr-1, thereby restricting the variability of expression of mec-3. Required to determine the identity of ALM sensory neurons, acting by interacting with unc-86, thereby preventing unc-86 cooperating with pag-3 to induce BDU-neuron specific genes. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. Promotes outgrowth of lateral dendritic branches on the PVD nociceptive neurons, probably acting both directly, and upstream of zinc finger protein egl-46.
Subcellular Localization:
Nucleus.
Sequence:
MEMLESKPLSAISMVIDSIGVDHENQNKCNCCNEQIYDRYIYRMDNRSYHENCVKCTICESPLAEKCFWKNGRIYCSQHYYKDHSIHRCAGCKKGVSPTDMVYKLKAGLVFHVECHCCSLCGRHLSPGEQILVDDTMMTVSCMSHYPPQMDDNAPGAIGSAVDIPSCSTENPIAPYPIDESFSSAFQVKKEVDAYGYNFEHYSFSDFCDDDSRMLKRRGPRTTIKQNQLDVLNEMFSNTPKPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPIHFRNEEMDTTDFNAFCGNFEEEDDED
The following text describes a protein:
Function:
Transcription factor that possesses transactivation activity. Transcription activator involved in response to abiotic stresses. Plays a positive role during dehydration and salt stress. Binds specifically to the 5'-CATGTG-3' motif found in promoters of stress-responsive genes.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing NAC002 exhibit improved tolerance to drought and salt stresses.
Subcellular Localization:
Nucleus.
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MGMGMRRERDAEAELNLPPGFRFHPTDDELVEHYLCRKAAGQRLPVPIIAEVDLYKFDPWDLPERALFGAREWYFFTPRDRKYPNGSRPNRAAGNGYWKATGADKPVAPRGRTLGIKKALVFYAGKAPRGVKTDWIMHEYRLADAGRAAAGAKKGSLRLDDWVLCRLYNKKNEWEKMQQGKEVKEEASDMVTSQSHSHTHSWGETRTPESEIVDNDPFPELDSFPAFQPAPPPATAMMVPKKESMDDATAAAAAAATIPRNNSSLFVDLSYDDIQGMYSGLDMLPPGDDFYSSLFASPRVKGTTPRAGAGMGMVPF
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MGESELSRLVASTAQLIIARQALCETLEKTRELGLALSKSENKLQDIRGRLKPIEEAMAPLLLGTVSARCFSGQIEEALGPAKTVLKKFEELRALEVTLMRDPKENLDAYLVAVQKLDECVNYIKLNTKGTVRLLQDAAESVMQQEAVGKAHEQRLIESISLLKSYSTGEPNPNLDGGLLGIALERIAKEFKRILVQHTLPLTLPDRLDEAERTNGNGLTDQILLPPAVLKRLQAIMQNLSSNGGLEKCVESYREIRSTRAFVSLQGLKLDYLKTCNPEALEKMDWDILQTMIGKWSEHIEVAVKVLYASEKQLCEQVLGKVANGAYIDECLYKVARIGMGQFISFGEGVARSQRAPEKLFKLLDMYDALERCMPNVNSLFDGECCRELRLQLRELQKMIVAQACCTFWEFKQWVVEQQHEVSVAPDGSVTKLSSYVVNYLKYLVGDIYNPIMDKVLKIEQTWRGQARPEESGLAHGVLLFMQALERQVEARSNDYTDPALRYIFLMNNIWYMRTRSKKCELGGLLGDQWLTEQRRKVEQYTLAYEHEVWGGVLKYLTREGINSQAGRSVVRDLVAKRIRDFSSAFDYACQKHQRWIIAEEDLREGTKNAVVQAVVPTYRNFLSSFGHLLESGGGSRNYCKYTPENIEQMITDLLYGRLELSRPGAHQGGHGSHGPHGRQAHVPYAGDGHR
The following text describes a protein:
Function:
Upon overexpression inhibits growth.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Predominantly localized to 1 cell pole in stationary phase, with a few smaller foci elsewhere in the cell; polar localization depends on the minCDE operon.
Sequence:
MSKEHTTEHLRAELKSLSDTLEEVLSSSGEKSKEELSKIRSKAEQALKQSRYRLGETGDAIAKQTRVAAARADEYVRENPWTGVGIGAAIGVVLGVLLSRR
The following text describes a protein:
Function:
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs.
Subcellular Localization:
Nucleus speckle.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDEYDKKRRLEHGGSDRSRSSNDNRNSHGSSGNNYRDDRKDDRYYRDDRSHYNNNNNNNNNNNNNNNNNNGNGYRDDRNYSSQNKYQNHHQQSPPQQQQQQQNSSYVPSQPPQQQTQTQQQPHIQAPPPAKPRKSRFDQAPETIPIQAPQQPPMISNQPIFKQQPMYQQPMYQQKQQQPQPPIFQQQQKQQQPPIFQHHQPPPIYQQPPVYQQQQQQQQPVFQQQQQQRVATEAIQFQQTPQQLAIEQERLKQERENEKKIEQANLEEEMKKRREKVEQWRKQKLEQELKASGSSNSGSTSSPPTTTTTTTKTTAATTTATTSPLTIPSQQQQTATTSPIKKKWSLEEEEETAQPLVNTNIEQKEIKLPPTANIPAAAATTTSATINTTTIKQSIEEDDDIDPLDAYMENLNKEANLNLKKSKTSQMIDDDEKLEEESEGEDDGKDKTIKKGKKEMLHTDHTSIKYAEFQKNFYIEVPVLANMTETEVLDFRSELGVKITGKDCPKPIQSWAQAGLTEKVHLLLKKFQYEKPTSIQAQTIPAIMNGRDLIGIARTGSGKTLAFLLPMFRHILAQPKSAPGEGMIALIMSPTRELALQIHVECKKFSKVLGLRTACVYGGASISEQIAELKRGADIVVCTPGRMIDILCANNRRITNLRRVTFLVLDEADRMFDMGFGPQINCIVDSIRPDRQTIMFSATFPPKVENVAKKILNKPLEIIAGGRSIVSSDIEQFVEVRPTETRFRRLIELLSIWYHKGQILIFTNRQETTDNLYRQLSNSQYQCLSLHGSKDQTDRDETISDFKNKVKTILIATPLASRGLDIKDLNLVVNFDCPDHLEDYVHRVGRTGRAGNRGTAYTFITPDEERFSSSIIKALEQSGSKVPDELRKLNDTYEKKRKEGKDVLLAPTGFTGRGHKFDAAEEDKKNIERKQQRKAYGIEEEEEEEDEDKEKAEKEKLAAASAEKEKQLLSEKEKLDPATTNTIVIPGVDGTIITPSSLLQTDPSVPVGQQAINQIFGISQVTSSEEAIKKLQLAAQLGMKGNIQKLNNQITPLNQTHFIEELEINDYSQQARWKVTHKDALLEITNFTNTTITTKGTFFPPNKIPAPGERKLYLYIEGPSDASVKNAKSDIKKILDEVQSTHQSTGKYSVF
The following text describes a protein:
Function:
Involved in hypoxia tolerance.
Domain:
Seems to have a cystatin/monellin-like domain.
Sequence:
MDVALKLLLLAALTLLASAQTPIDYKDLSTTLQEHIDKALEEGNRKFGGRHHVALDSFVTPAVTRQSILNVNVFLKVTTCMKTRSYKHRPECNTQKRSTPKINCLVCKMKNGTELVHCARKIDILHGEHKEIRDNCDVTRIGVSSLMAQTMPDDYRKQVGCLGCI
The following text describes a protein:
Function:
As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor. May also be involved in the biogenesis of lysosome-related organelles such as melanosomes.
Subcellular Localization:
Lysosome membrane.
Sequence:
MAEQVTEATASGVFCSRILNMVNSEDVNAIILAQRHMLDRFEKTNEMLLNFNGLSNTRLQQMSDRFAHHTRTLVEMKKDLDIIFRRIRMLKGKLAKQYPESFNNVHESPILEDDDDFDPTPRSAATTIATSEQSTESCDTSPSIISPAMSQDFEDLSQAPSDTPSVNGQILTDEEVVHED
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAPASIEGPSKEGDQQASSTVNMAALELDTHCPYSILPSILFQMNSDKDMDRLNKVGGAGGLAKGLVTDLHAGLNESPAAAAADGLATAAASELGSVEAHRKAYGENKFPEKPPPNFFMMLLEAAKDPMIIILLIVAIVTIVLGAAVPEQRAHQGWSEGLAVLGTALIVIFLGAGQDFSKERQFQKLNALKDVIDVKVTRGGKQVLVPNTEVVVGDIMFLDTGDKVIADGIVIDSQGLVLDEASLTGESDPIKKDPVSDPWVRSGTTVNEGSGHMLVLAVGVHSEWGKTMALVNEAGDDETPLQEQLTDVAAKVSKMGVLVAVVCFLALLIKWLIVTGGGDIDKINDNGPLQFLLYAITITVVSIPEGLPLAVTLTLAYSMKKMMKDNNFVRVLSACETMGGATAICSDKTGTLTENRMTVVEGWFAGTAYPQVPEGSVLGPQVLELLKWNCAMNNKAFLVDQESGVTDFVGNRTECALLVLLRKLGFDYKQLREEREADQIKLYGFSSARKMASVLLRERAAGGNLRLYNKGAAEWVLRRCVGLARPDGSTEPMTPAKLEEMNALVTGMAKRGLRCICLSYRDYAGSDPARPADFFEDADQVDRDLIAVAIVGIKDPVRKEVPDAVATCQKAGIVVRMVTGDNIHTAQHIARECGLLTTEDAIAMEGPVFRAMPATELIPLLPRLRVLARSSPEDKLTLVSLLKKQGEIVAVTGDGTNDAPALKESDVGLAMGIAGTEVAKEAADIIILDDNFSSIVKSVLWGRAVYMNIRKFLVFQLSINLVAMISAAVGALYGGVPPLNVLQLLWVNMIMDTLAALALATEDPYPELLDDKPHGRSEAIITGLMYTHIVVAALYKLFWLFACLYGLPRVLPAYATLTKGEYYQTMCPEILNDKGVLSTNATLQGDVCNIMGFCGFPQGDIHSDLCVLHNEWLAINTTVPSLQQDAVCNGQFSPTANFSGVVAPGEACVRNTNLESAQRAMDDEWDREYLLSYKPALSVLFNAFILAQVANAFVSRRIGLELNFFKGLAHSPIFNGIMVLITALQVLIMQTPISYIFKVEPLNGPEWGACIAIGIGAIPFSWALRILLRWLLPLTANSSHWLAGLRGSRASNITASGAGPMRQAARTRTLSGGAASANHNRTASGRTLSGPNGGHQDHHRAMSGNPHVVISTQYQVGVLGNGRVASGMPVGEASVTERGLDASARVARVGSLGRVVPEPSSPAIASQSASRAWS
The following text describes a protein:
Function:
May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDNSTQKDQHSGKKYSRKANKVQKGFTAAYPTQSSIPYKYQPLIIPESEKKGFNSQAKRFYHKQDDIPGPGFYNVIHQSPVFDSVSLSKKGTCTFPSMCARLDTIVSKFPAANAYTIPSRLVSKKDFSNSCSSMFQLPSYEKVLKFETPAPNQYNASDSCCKQANNVCARAGFVSKTQRGLFTVSKTGPAPGHYDVNESLVKQSPKILMSCFKSKTDRGLKLTSTGPGPGYYNPNGHPKVQKKTLIPRNPILNFSAQPLPLPPKPPLPGPGQYEIVDYTGPRKHFISSASFVSNTRRWTAGPSQPGMPGPATYRPEFPGKQSFLYNEDNKWIPVL
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD1.
Sequence:
MSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEGTIDVVRVLHQRMDVDRNL
The following text describes a protein:
Function:
Liberates mannose from p-nitrophenyl-alpha-D-mannoside in vitro.
Sequence:
MVIPGLSVLIYVIVSVTTCLSLESVNGVYVKYGTDARVVPDKLNVHLVPHSHDDVGWLKTVDQYFIGSNNSIQKACVRNVMDSVMDSLRRDPNRKFVFAEMAFFTRWWGEQNPETHEQVKKLVNSGQLEFVNGGWSMNDEATCHYIDMIDQMTLGHRFIMQTFNITPRAAWQIDPFGHSSVQAYLLGAELGFDSLHFARIDYQDREKRKDEKSLEFVWRGSETFASSSQIFTNTFPVHYSPPSGFHYEITDDYAPLQDDPLLDAFNIKDAVDNFVNASLFYANVTRGNHVMWTMGDDFQYQFAESWFRQMDRLIHYVNKDGRVNAVYSTPSLYVDAKNAAKNITWPLKTHDFFPYADRDSAYWTGYFTSRPAFKRYVRSLSGYYLAARQLEFLVGKKSGGPNTCRLGDALAIAQHHDGVTGTAKQHVTNDYAKRLAHGASEAEAVVNSALAHLMNKARTKPDISLAQCSSMNMSYCPVTEETISGQKSLILVAYNSLAWNRTEVIRIPVNDAGLNVEDSSGKTLDAQYIPMDNVTSNLRSNYSKAYLGVSSQQIPKYWLVFKATVPPLGWNTFFISKEPGKGSDKNKHSPGTFSPMKGITEIGPGNLKLVFSQDSGLLKQMHNSRTGANILVDQNYLWYASNVGDSKNSQVSGAYIFRPNASLAYSVSSKPELQIVRGPLVDEVHQQFSPWVSQVIRVYKDKEHAEFEYTIGPLPVGKDYVGKEVITRMVANMSTDKTFYTDSNGRDFLKRVRDNRTDWTLKVNEPIAGNYYPLNLGMYTKDKKVELSVLVDRATGGGSIKDGELELMLHRRTCMDDSRGVEESLEETVCINGTCTGLTVRGNYYVSINPVGGEGARWRRGTGQEIYTPLLMAFTHENKEKWKGSNSVKGNAMDPHYAFPPNVALITLEELDLGNVLLRLAHLYEAGEESEYSKVAKVELKKLFPGKTIKGVKEMSLVATQEKAKMKEKMKWKVEGEAEKSQSSSHPQKGGPLDSSALVVELSPMEILKTENIAGLQQKYTQSGGVRPFGLSTLIVGFDPYSRVPSLYQTDPSGTFSAWKANATGRNSNSIREFLEKNFKETSGQETVKLAIRALLEVVESGGKNIEVAVMTREESGLRQLEEGEIDAIVAEIEAEKAAAEAAKKGPQKET
The following text describes a protein:
Function:
Involved in an early step of the mitochondrial complex IV assembly process.
Sequence:
TPRYYKDKLKEDLGVCLLQSNCVVQEGKSPLQCLKEGYCKALKYSFFEYKRSVLDIRSRTRGRKGY
The following text describes a protein:
Function:
Involved in vesicular transport between the endoplasmic reticulum and the Golgi.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Sequence:
MNQNSSLSSSGMMGSGGFGFDQFSNNFSIKTKQIESINKMLSLKSESSSSNNNNNNNKAISGWQEVWKVLIFDTHCSNIIAPILTKGALRNQGVTLYLPLHSDRQPIQDVPAIYFVLPTSDNIKRIAEDCKNKLYDNIYLNFASKLSNQLMEELATLTIQSDSVSMISKVYDQFLNFISLENDLFVLNNPRDSYLSFNDTRIKDTQAQENIDMVVDSLFSVLVTLGVVPIIRAPKNSAAEMIALALEKRISTTLQSSGGSNVFSNMNEMGSQLSSFYRPVLILLDRNVDLSVCLHHPWTYQALVHDVLNMSLNQVRIDVTQNGQTSKKSYGLDSSSDSFWSSNTGAAFSSVAGEIKSQINEYYQQMEKLQQITDIKLDDSDDFDNNNKKSNENKTKGLGNLVQEMDEKKRLIDIHTNLATDLTKNIRDRQIDCFFAMEESIITRSLTDKKELHSLITSPIVGETGGRGTLEDKIRLLIIYFLSTKNVPQSEMDQYEDALTKMGADLSTLDFFKKTKAFNESLTAIANVNQSSTQSSNTASGKIGGFMQMMTSVTGYQGVESFTNFFQQGVRALLPKSKDLFVTRIVESIMDLKNTLDADYLYLDPKIQNKSNVPKRTTPFKEAIVFTVGGGNYVEYQNLQDFSKKHNKKIIYGSNELLTSKEFLNQIKNLNKN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome. Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation. Does not ubiquitinate proteins that are acetylated at the N-terminus. Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy. Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1.
Subcellular Localization:
Cytoplasm. Late endosome. Lysosome.
Sequence:
MSRHEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSSREAMDPIAELLSQLSGVRRSAGGQLNSSGPSASQLQQLQMQLQLERQHAQAARQQLETARNASRRTNTSSVTTTITQATATANTANTENSPQALHNSQFLLTRLNDPKMSEAERQSMESERADRSLFVQELLLSTLVREESSSSDEDDRGEMADFGAMGCVDIMPLDVALENLNLKESNKGNEPPPPPL
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSSTAVQPPPPVPPPPPSAVPSAGKGIHSKLYNGMIGAADKFVPAKLRPLWMHPAGPKTIFFWAPVFKWGLVAAGLSDLARPADTISVSGCAALAATGIIWSRYSLVIIPKNYSLFAVNLFVGITQVVQLARAYHYHQSQEKLKQEQQQPAVQN