lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MVRLAKFYLVCYNSLQSLGWFVSLLRLLPCLVPPFPVHSAYVVAGDLICFLQTCAILETVHAAIGLVPTAPLLAFLQWGGRIHFILAVVRQIPEVQSSPSVFITFIAWSISEVIRYSHYALTTLKVCPAWLTYLSVDNVPSPPVCEEEGPLLRFLREVLHELPFLSSGCAGALPVPVAEAVPARVQAAQVQAGEGEQEETGLRKSGSAQLSCHLLLSCETLTGHCGFLFWKKIFVSCCLMRRGQLLDYALGSLFVSIALRFMSVLTYIKHI
The following text describes a protein:
Function:
Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription.
Sequence:
MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELDYTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQTELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEFEAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMFNIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLICQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST
The following text describes a protein:
Function:
Pump for glutathione S-conjugates.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGFEALNWYCKPIAEGFWEKTPDGAFGAYTPCAIDSLVMIVSNSVLLGLCFYRIWITLYNAKAQIYVLRKMYYHCVLWILACCCVVEPVLRLVMGISLFDMGDETDLPPFEVASLMVEAFAWFAMLVLIGLETKQYVKEFRWYVRFGVVYVLVADAVLLDLVLPLKNSINRTALYLCISSRCCQALFGILLLVYIPELDLYPDYHILNNESLDNVEYDALPGGVNICPERYASIFSGIYFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLIKRFQRCWTEESRRPKPWLLRALNNSLGRRFWLGGIFKVGHDLSQFVGPVILSHILQSMIEGDPAWVGYVYAFLIFFGVTFGVLCQSQYFQHVGRVGFRLRSTLVAAIFHKSLRLTNKARKNFASGKVTNMITTDANALQLIAEQLHGLWSAPFRIIVSMVLLYQQLGVASIFGSLILFLLIPFQTLIVRKMRKLTKEGLQWTDKRVGIIYEILASMDIVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAFNSFILNSTPVVVTLVSFGVYVLLGGDLTPARAFTSLSLFAVLRSPLSTLPNLISQAVNANVSLQRIEELLLSEERILAQNPPLQPGAPAISIKNGYFSWDSKTSKPTLSDINLEIPVGSLVAIVGGTGEGKTSLISAMLGELSHAETSSVDIRGSVAYVPQVSWIFNATLRENILFGSDFESERYWRAIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQRVSMARAVYSNSDIYIFDDPFSALDAHVAHQVFDSCVKHELKGKTRVLVTNQLHFLPLMDRIILVSEGMIKEEGNFAELSKSGTLFKKLMENAGKMDATQEVNTNDENISKLGPTVTIDVSERSLGSIQQGKWGRSMLVKQEERETGIISWDVVMRYNKAVGGLWVVMILLVCYLTTEVLRVLSSTWLSIWTDQSTPKSYSPGFYIVVYALLGFGQVAVTFTNSFWLISSSLHAAKRLHDAMLNSILRAPMLFFETNPTGRVINRFSKDIGDIDRNVANLMNMFMNQLWQLLSTFALIGIVSTISLWAIMPLLILFYATYIYYQSTSREVRRLDSVTRSPIYALFGEALNGLSSIRAYKAYDRMAKINGKSMDNNIRFTLASTSSNRWLTIRSESLGGVMIWLTATFAVLRYGNAENQAVFASTMGLLLSYTLNITTLLSGVLRQASKAENSLNSVERVGNYIDLPSEATAIIENNRPVSGWPSRGSIQFEDVHLRYRPGLPPVLHGLSFFVYPSEKVGVVGRTGAGKSSMLNALYRIVELEKGRILIDDYDVAKFGLTDLRRVLSIIPQSPVLFSGTVRFNIDPFSEHNDADLWEALERAHIKDVIDRNPFGLDAEVSEGGENFSVGQRQLLSLARALLRRSKILFLDEATASVDVRTDSLIQRTIREEFKSCTMLIIAHRLNTIIDCDKILVLSSGQVLEYDSPQELLSRDTSAFFKMVHSTGPENGQYLSNLVFERRGNGMSQGG
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MDEPKKPKWGITHSISEAPPTEADNKLNDNLIETLTRLNVFETLEGNKRREEVLAHVQKVVEEFVRRAGKLKGIAQSTLDVAGGKIFFFGSYALGVHGPTSDIDTLIVVPKHVFIEDFFKIFPSIFRELSNAEDISELVPVEDAYVPIIKMEYRGVSLDLLFASMPTMSSVPKELETVDKSVLRHLEETTIRSVNGTRVVKELLSSVPQRRHFRYALRAVKLWANRRAIYGAVFGYPGGIAWAIMVARICQLYPMACGATILSKFFNLMHKWQWPRPVMLKEHELPEFGLRVWNPAHQSYPPDARHLMPVITPAFPAMCSTHTVTTSTKQIMMEEFQRADKIVRDVFNGQGTWEALFNNHSFFTQDHKYYLSVIAASRTKEADLTFHGLVQSKVRLLVAGIDDGQTGIDMARPFPEGFERVHRCKNEDEVEAVTKGSLDYMIPVSQVPAAGTTEDHIIYTMTFYIGLRLPKERSTLDISYITNHFRSKITESKLYDEGTMSVKVVHTRNTALPDDLFKPGEVRPAKAKSTKDKKKSKGGAKRPHTETGFPDSEQQAAKRRQTEPAANGVVPPTAA
The following text describes a protein:
Function:
Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAARLLRVASAALGDTAGRWRLLARPRAGAGGLRGSRGPGLGGGAVATRTLSVSGRAQSSSEDKITVHFINRDGETLTTKGKIGDSLLDVVVQNNLDIDGFGACEGTLACSTCHLIFEQHIFEKLEAITDEENDMLDLAYGLTDRSRLGCQICLTKAMDNMTVRVPDAVSDARESIDMGMNSSKIE
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Subcellular Localization:
Cytoplasm.
Sequence:
MKEQPVPANNESSQESTVVVHPAKVAPLSGPYGITGDLAGHLPSSILSPQAQGFYYTGYENPTGEWDDYSSYVNVEGLDITSPVGFNENASMVYQTGYGYNPQMPYGPYSPAASPLPSEGQLYSPYYQQVVPPSMQYISSPTQPELTSLVGVDQQGDNMGGPRPSYHPHPIGPFNGNQPNLGFPEWQQGFDGGIWSDWSKPSDMHRHSSHVSPALSPQPLGSFGSYGHNIPMGSQRQRSFYGYGSGSNSYNRGYMHSGGHGQGSNYGSRLISNVSMGNQSWIGVDNIRGRGRVSDPSSLGGGYNGNFDILNEQNRGPRASKPKTQVSSEELDSSADTKKHNKSSTKEHEDSNNNSNDFVTDYNNAKLFIIKSYSEDNVHKSIKYNVWASTANGNKKLDAAYREAKDEKEPCPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWSGQFPVKWHIIKDVPNSQFRHIILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKSYDAETSILDDFEFYEEREKIIQDRKARRQPSLPSGVVESGDKPSSAAALQTDLIKNMSKSFAQVVRLDEAAKTSSPPDATTTTVAVSQSN
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDINFMVVDGSLADLVAELTAYIETLGCDELEANCQRALAAGEEPKVFELITQQLPLLNKSSEQQFESVWQLCLHVFSFSESFEWVDAVLKAISGHSNLPRSFNGPAAAGQAVVAVLASLFNMLSSSHDDAQLANTLLAALTTAEETGNLHLLAGQLKSDQTVTWINTWQIEADVRDQLIAKIYSALVQLDEPAKALALLVAAVGNTQTSTFPMTCKLVQQALKSDHVYDFGSILALEPVEDLKTTEQRLFELLTTVASGEVAKMQSLAAGDAKSLIEENDFDAESLLAKTRVIALANLAAESPEIEYSIIAKNLDVSLDTVELWVIDTIRAGLVEGRLSQTKQSFAVHRAQKSGPIAKADWEVISQKLDVWKKSINDVLHVVKQARENANAQKRKIAA
The following text describes a protein:
Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Subcellular Localization:
Nucleus speckle.
Sequence:
MSWPQWSAAPQPSVPPVLNPTTPVINSAPSVVPPGLQYTPEQWAQLQQQNWNQWAQWQQQYQQWHQQYGAEYQKSINALAQAAQVQQTPALPNVAVPPPLPADNRPPPPVDEPPPPSYTSAPPPSHGYNTAPPLKTMRQSWGNQNYRFEQQKRNYEQPDDVNKRPMVNKPGWQQPRPSKDNLEELSEAEKKFDKQFAEWEAQFNKWKEQNAEHPDKEQYREYEKKWESWRAQLLERREQMKRKRLGLAVDSPSKSRPGSGQSFNSPQANFNQPPPKVLPSVPPKEGLLPLPQPSFNKPPPTLNDEPLKFKDSKPVPELDDSVSSFFKPNTGGGIPGLDLVKDDPKPDKSATEDVVLVDPEEKEREKKGPDFDAISKGINTILGDQKLLNMLSNSQIKVSRIIPIMGKVTHKENLLILMIKLGAASRWLATTRKRDSMDLEVSSKRIKISFQIDLGILIKEIALGVSTKGKAILVQDPTKGFHQEARISLDFHQIKIKIGLVQIKISLPRIKISLVQIKIGLVRTKISLVQVRTGLVRIGLALIKAETGRTNGLGLIRIGLVLIRASLVRIRISLGRIRNNLVRISRDSVRTKTGLDLIKIDLALVRIRDRNFSRGPPQKGQFNYNNDNNFNQYDNDQGYNEEEYEENYDYDQVASNFEEETSHSMDWKEEENYEDQNQPPVVEQEPPEAPKITGIFQPSEVIDYEHKPPKLGEPEVLIEPIYMFDYRHKPLSRIPIPQRPKWLADVVKNIREFDPPTVRPYEPNLRRYPPPMDHWRKDRYQENWSPHNRRSYNDDRRPYGDRYDEPPMEKRREDRRSYPEEKKQFNRMELEEEKISDTEWPDDDFEAEKPNFTKFQKPDKPTKNVVLIEDLISPPGRFKRPPRIVIILRGPPGSGKTFLAKLIKDKEVENGGSAPRILSLDDYFMVEQEKEVTEEGKKVKIKEMVYEYEAEMEESYRTSLIKSFKKTITDGYFSFIIVDNVNDKVKYFGEMWSYAKQYGFQVYICQLDLDVHTCSKRNIHGRSEADIERCVSNWEPTPQHHPILDATSLLQSASIPEVEMEEVNSPESDLNECDGSEDQVARSKWDTFDCSVDNLAKLDGVSKPLRHRTMEEYLQLDTEWTPIKPTKPGQKRVRWADLEEQKQQEKMRAIGFVVGHTDWDRMMDPTGGSSALTQTKYIERTGRFKVDQK
The following text describes a protein:
Function:
Acts as a component of a SCF E3 ubiquitin ligase complexes.
Subcellular Localization:
Nucleus.
Sequence:
MRDDGATTMPPRSAPSRPPPWEALSLVANFLDAASLAAASCVSTSWHAAFSDDHLWARLCRCHYPSAIGLLPLSDSSVNAGDRRSSPHRGLFALFHSAASRGRSLPEPRLALADVTFAVDLFAAGGQNMLSFAVAACDAGVKKAPGGVFQFAVDVSDRNAVAGPGKHWSVRWTAVRTGLGVAPAAIVMMDAKLPASRAGALGSGVRGESWATEGLPAPGCGGGKLEAEAVVEVSGEERLVEKVRLGVLLDCREESFPSEYI
The following text describes a protein:
Function:
Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.
Subcellular Localization:
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Detected at the boundary between cells with actin-rich protrusions.
Domain:
The first PH domain mediates interaction with membranes enriched in phosphoinositides.
Sequence:
MGNAESQNVDHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKAIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQEGALDDFGDPIWVDRVDMGLRPVSYTDSSVTPSVDGSIVLTAASVQSMPDSEESRLYGDDATYLAEGGRRQCPYTSNGPTFMETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETEASPRQLSTCQRANSLGDLYAQKNSGVKANGGPRNRFSSYCRNLVSDIPDLAKHKMPPAAAEETPPYSNYNTLPCRKSHCLSEGATNPQISLSKSMQGRRAKTTQDVNTGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPPTGRAFVGSDSGSSSTGDRARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYETDGRSGIDHNSVPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACAAAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVSSFHALVAARTGEIGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPTINQVFGEGTDAVKRSLEGIFDDTVPDGKREKEVVLPSVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLMENRVQFYIPQPEEDIYELLYKEIEICPKVTQNIHIEKSDAAADNYGFLLSSVDEDGIRRLYVNSVKETGLASKKGLKAGDEILEINNRAAGTLNSSMLKDFLSQPSLGLLVRTYPEPEGGVELLENPPHRVDGPVDLGESPLAFLTSNPGHSLSSEQGSSAETAPEEGEGPDLESSDETDHSSKSTEQVAAFCRSLHEMSPSDSSPSPQDATSPQLATTRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPIQRVLKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTSVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEEWDPFRFRHMIPTEALQVRALPSADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKSVHSILRDKHRRQLLKTESLPSAQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFTIDSDAISASSPEKEPQQPAGGGDTDRWVEEQFDLAQYEEQDDIKETDILSDDDEFCESLKGASVDRDLQEQLQAASISQRARGRRTLDSHASRMTQLKKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI
The following text describes a protein:
Function:
Required for ciliogenesis and for structural integrity at the ciliary tip.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MDPESLDYTIVSCSSEDPHYPITSIQNASIRSNGWQSQQNPSYPVSFVVDLGSKAEIKSLQFVSHQSKIPARVDLSYGDNGTLFKPLGSFQFSDNSQTGYSARELKSANLSKVSTRFFKISIRGCHTNASNPFNQVGIVSLKILGNGGRPASSQRPTTPELDLEQEINKLERQKADAVAREDFSEANNIKIRLNELKSQKETLENLKKRKAEAIAAEDFEMARIVNDQLKAFNNKDYRPYTTQAKPREEIVKYDNNYNSARHEKQPPKNIEPPRGRQIPNDDDDNSPIPSSKDYELPDSFDNDASPAGCAIPRDSDESPRPGRSIPRDNDDIPPPGRSIPRDEKDVSRRDHRIIEPVEDDEDQVQDLEEEPPEPAKPMKKGKYGMTRPILGGNMDQAPPQNDYEPADLSEERPIHPADDYNEDPNGGLRGITEDSSTPDELTPASRQEASLLISKFGEDAVARFYSKNWQLRIEGINILGKRIKELGQVSCYEAFCCFCKIMRFRMSDTQKAIVSDGIQVIQDIADTNVIQNGDLARAVQSMLAPMATRIGGNSQPISEAVCNFLVFLCSNGCSDIVLPIIYGGKKNSANWKSLQARISCLHDIVLFLGMDAADGLSLDQMMKLAVEGLESAKSEVRLAATQLVVTLEEMAGSAIEKYIEKIPKRTREEVSKAIEQNHQKNQNEEM
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAKEAIPIPIGIVLDLNSSIGSMSNSCIWMAYQDFYERHPHYKTRLALQTRDSRDNVVTAASVGTQELLNEKVHAIIGPQTSEQAWFVIELGSKAQVPVISFSATSPSLSSTQKPYFIRAARDDSSQVEAIAAIVQGNGWREIIPIYEDTEYGNGLNPYLNDAFVKIGTRVPYRSVIMFLVHMSTDLGCKVFLAAKKEGMMTIGYAWIVTEGLSAEVDPMVLKCIGTMQGVLGVRPSPKHTKRLDNFKERYGNTVTIFGLWAYDSVWALAKAVEKVWGENVTATLHNTILATKFHGLSGNFHLVKGQLEPSILEVFNVVEQTERSIGNWMPERGLSKLEQPKWPGNTTEPPAKLRIGIPPTNSVNEFKKFLNFSFDVFFEVLKVLPFPLHYELLPFEKHGETAGTYDELLMQIKEKKYDAVVGDVTIVAKRSEYVDFTMPFSESGVAMLVLAKHDERQNIWIFLKPFNWDLWLTTGAAFIFTGFIVWFFEHRSNTEFRGTPKNQIGMALWFSFSTLVFAHREKVENKWSRFVLIIWFFVVLIITQSYTASLASILTVQKLQPQFMDVEEIKTNNFFVGYHKDSFVKGLLIEKLGFNESKLKGYHGPKAYQQALSLGSNNGGVAAVFDEIVFINLFLMKYGCKKYQIVGPTYKTDGFAFAFPRNSPLVPYFSRSILNVTENKTTFDGIKKKYFSRDVISEDPSTRMAFRSTNLTLKSFGGLFIIILFTSFLAVMVHLFKFMHSKWTARDFQRSLSEMMTELAKHFNKEECSLHPPPIMEEGSLDPDGTNYQSIIHNEEDLRQL
The following text describes a protein:
Function:
Exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry.
Subcellular Localization:
Virion.
Sequence:
MAIERQAVQGLRRVQSTGGPSAASFATRQVGVQETSASGSRFLEDLVNAAGSLATVTTSILNQRVEDDKVRQYNRALTGLMPTEDATVGGARAHMLVSLQNDIIAQTMQLSDDAQRFDGDDSQWEDHVINARMAVQDRLWDTYPELRGDKESMRVVTNAFMEQQPKIFAARETAKLKQEAEARIKSMESRILLATRDVPGEAMGDALNQLQKEAMAMQITKQEFDALVSQLAANRAAIGDDSMIQGTKSLKDENGVSLYDRVGQLQTGEIQANRTWAAQNQVALFEKKDAAIKAFEAGQLNREQLLQVMQNHNEISGGTAWSDSEIKSLFDRQAKARATSAKLEDLVARGEHGSPLGLQDISKEDRKAYAGALVDAYTKLANDEITRTGATGEEAEAIRGRYEQMRYAKLGQQLIEDPIIKERYGSLMQLSSANLKDMKIEPEALQTIMRARDSIPEDARRAVMGDKEYAFAENYDLATRMGYTPGQAIEFAQNASRGDKLPGSVMKELNDEVDGVVSDVASGSWLTRGDNMSDMGRDLMLEEANQIARSMKVAGHNNDTIKRHLKSFLQNQYTQLSEGFFTQGVLVKGDVRTLGDTIGANQKDVPTVLRQYLDNHKQALLDASGGMEEGDLYFDVDSKRGMFTIRAGSGRVPVTPAMPLSEIKGQDLLKEHYEKAVKERDEAKKNFEANQMRMWGAGGYQSPAPEKTTAKTVGSRGIADFLMSPAFASGENLPSNFEFNYKRNNMDFYNYVAKTENGANVGFDRVAGVYTPYKDAHGQSVGYGHFLTEEEKKNGYITIGEDKVPFAPGQSQLTPERAMRLLEQDMKSHVPSTKDWAVPFDAMHPGVQRGLMDLSYNLGKDGIKNAPKAYAAFKAGKFTDGFIEMLSTASTEGKRSSGLLVRRAEAYNLAQSGGSVPKISEVETREDGSMYVKFSGSMSEAFVSKSILGKIGKDGWMEVYPPKAGALASGTKVGRIKL
The following text describes a protein:
Function:
Involved in the transfer of galactofuranose (Galf) onto an alpha-D-gluco-configured acceptor substrate to form a beta-1,6-linkage. It uses n-octyl alpha-D-glucopyranoside as an acceptor substrate for the addition of galactofuranose from the donor substrate UDP-galactofuranose. It is not able to use beta-D-glucopyranoside isomers.
Subcellular Localization:
Cytoplasm.
Sequence:
MYFLNDLNFSRRDAGFKARKDALDIASDYENISVVNIPLWGGVVQRIISSVKLSTFLCGLENKDVLIFNFPMAKPFWHILSFFHRLLKFRIVPLIHDIDELRGGGGSDSVRLATCDMVISHNPQMTKYLSKYMSQDKIKDIKIFDYLVSSDVEHRDVTDKQRGVIYAGNLSRHKCSFIYTEGCDFTLFGVNYENKDNPKYLGSFDAQSPEKINLPGMQFGLIWDGDSVETCSGAFGDYLKFNNPHKTSLYLSMELPVFIWDKAALADFIVDNRIGYAVGSIKEMQEIVDSMTIETYKQISENTKIISQKIRTGSYFRDVLEEVIDDLKTR
The following text describes a protein:
Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Sequence:
MWVFGYGSLMWKADFPHSRRVVGYVKGYVRRFWQASEDHRGVPGKPGRVVTIIPSNDPEDCVWGVAYEIPEKHIQEVMYYLDFREKDGYDKVQVIFHPESDSTLEPFPLTIYVAHRDNPFYLGPASIQDIARQIRTAQGPSGPNREYLLKLAEAMRSLAPHVKDHHLIELEHELINLDMNETNGHQPQDEARQSMMA
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKENQTLPEFLLLGFSDLRALQGPLFWVVFLAYLATFLGNSMIILLTQTSPALNSPMYFFLRHLSVVELIYTTNIVPRTLVDLASPYPRAISFQGCAAQMYIFIVLGISECCLLTAMAYDRYAAICRPLHYSTLMNWQVCVAMVGTSWFMGIITATTHSSLIFTLPFPSHPIIPHFLCDILPVLRLASAGKHRSEISVMAATVILIMIPFSLIVTSYARILGTILAMASTHSRHKVFSTCSSHLLVVFLFFGTASITYIQPRAGSSVTMDRILSLFYTVITPMLNPIIYTLRNKEIRNLDQAQKDGLSLPHNVCVIYWEDSIARRDSNSWEQNHLTVSSFTCPVPAMTGFVDQNTYA
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MNKAAIYAKYNISEDYPETFTESENFDLSVLPEADPAQETKSGAASASVNTSRYVLLNQLVGGNKHSRHAITDDEADPLGFSASVMTQLRKKGVDCSESPAIANQYFISSRDFNPRVFLRDVHADASFDTLAQSLDHLEASITEQSSALQTLVDRNFDKFVKSKSYLDSVFKQFKSSGFTQENEWGMGELTQSLDEGNSKAAILMNPVFNTRLKEERLQAALEMVTANRYLFELPSTIRAHIKAGDHENLMRDYKRGKETKNERMAQAEQLGDMTTVHMTDRMWNDVEDIIEEYEKSCWTKLEAAPAGSHLPSISRLLELQVTTNPVVYWVKHRAAVIQQEINSTCEKLMLSITIARTEILALPENNTVWVENIIEEVRGQPCAPPSTKMWITVKKFVVDINALCARIEALWKGTRDFIDGIAQQQLPPSEHLKFSEVDARTLYASIGGLIDLAAQQIGEFFTQKPKVMNHSKLDAADVEGGPESFQETWKRFGFLPPHSNALTTCKYLPQLVLDLAVSCGNIVNTRIPGQNVETLRHVLDLARTRSVEALCAVWKDDTSKFELLENWKPSRKQGKGHVTHVPQTVFEYQKLVLSGLKKVLFLNTNDQGQRDVQVVLPPAPKLLQALQTYFLSTNLMIVDSIIKLVSGEENSKPDAQLQQLATRLKGEMDATDYISVQTSPLPADTKILWVVSNLGELKTNVIPPLVKQFQKQFNTQVKFDYDALTQSEQKLFSTYTAPKKAALTAVIKEGIQGNKERWPSNANPTDISNYIYESLLLLVVVHAQLMSISPQLVSPVTHALQQHALESLLEAIREVELFGPGGMYQAVADIEFFRTIMASYNTNNVQNVVQLIYQAIQQSSGDQSAWTGRHGPWEKVQKLVGECATRTFVCFSCFRS
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Sequence:
MVKRVYSKTYTTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKYTLAKIRKAARTLLTLDDKDSKRLFEGNALLRRLVRIGVLDESKMKLDYVLGLRIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNVPSFVVRLDSQKHIDFSLSSPFGGGRAGRVKRKNMKKGSKTDDAEEDEEEEDNE
The following text describes a protein:
Function:
Baeyer-Villiger oxidase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH that catalyzes the oxidation of emodinanthrone to emodin (By similarity). Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC mdpJ, mdpK and mdpL. These enzymes with xptA, xptB and xptC are also proposed to be involved in the synthesis of shamixanthone from emodin. Especially, direct reduction of emodin by the short chain dehydrogenase mdpC followed by dehydration catalyzed by the scytalone dehydratase-like protein mdpB gives loss of oxygen and formation of chrysophanol intermediate in two simple steps.
Sequence:
MSSSINILSTKLGQNIYAQTPPSQTLTLTNHLLQKNHDTLHIFFRNLNGHNHLVHNLLTRLVLGATPEQLQTAYDDDLPTQRAMPPLVPSIVERLSDNSYFESQITQIDQYTNFLRFFEAEIDRRDSWKDVVIEYVFSRSPIAEKILPLMYDGAFHSIIHLGLGVEFEQPGIIAEALAQAAAHDSFGTDYFFLTAEKRAAGRNEEGETLVNLLQKIRDTPKLVEAGRVQGLIGTMKMRKSILVNAADEIIDIASRFKVTEETLARKTAEMLNLCAYLAGASQRTKDGYEPKIDFFFMHCVTSSIFFSILGRQDWISMRDRVRLVEWKGRLDLMWYALCGVPELDFEFVRTYRGERTGTMSWKELFAIVNEQHDDGHVAKFVRALKNGQEVCGQFEDGEEFMVKGDMWLRIARMAYETTIETNMQNRWVVMAGMDGAWKDFKVQSSD
The following text describes a protein:
Function:
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKLFSFTSLTLVAFTIYAANALWMIYSIWHPEECKLPERRKYCIKSHILEKKTKWKLKVFTSTKQQSQNELSAAKNPSVYQWKNFNFSKPKDVAINVTLPTETINNGSLYLHFLLHPHGESAFNNIHSLHQWTPVTGYLVPQSYFKLIHDNSTVFKKQQKQVTNSSETQAAITHWRPDINLHVMNQDIVFDREKIPMEILKLLRLENASYDGFYLPLFYVDDLAHKKSDLKSIPKNASEMQVTIHYSPISVGKLRLWIILTSAIKQMKSFGNWDVIMLYFNLHPGCQFKSFMRPVHTLRHHIVKQNXLSYVMYPLCLGAACYSLFYVPHKSWYSWVIQSLVNAVYAFGFLFMLPQLFINYKLKSVAHLPWRAFMYKAFNTFIDDVFAFIIRMPTSHRLACFRDDIVFFCYLYQLWLYPVDKKRANEYGVSYEASHEK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MPLAPPYRRKMPREPGTHLPTSQLLTGEENEALYKEEREENWLRPLDSEEKCSIKSETNLLGENNPTKTEVEPPWEEGDPPNPDISPTGPTRFLAYGTYREPTPWEDDDSDSSRNSFPGQIQGRDPDIVGKSLPANNESHRIDREEPEGSDCSSDPQTEETRGAATQTRICSLNNGSLANEIKEEAASWGDELALPPGGKQFSCSECGKSFGFLSQLNRHFKRHTGEKPFSCSLCGKSFSRLNNLKTHFVTHTGEKPFSCSECGKCFALQSHLITHFTIHTGEKPFTCSVCGKCFSLQSHLKTHFIIHTGEKPFCCSQCGKCFGRQSSLKRHFKVHVDRASLCLGGPVAPSDLRDPLHTMICGTPCTQ
The following text describes a protein:
Function:
Activates SnRK1.1/KIN10 and SnRK1.2/KIN11 by phosphorylation of their activation-loop 'Thr-198' and 'Thr-176', respectively. Required for the regulation by SnRK1 kinases of the transcription of a large set of genes, the modification the activity of metabolic enzymes, and the control of various nutrient-responsive cellular developmental processes.
Sequence:
MFRDNFLFARTMGCFGCFGTSSTRTRQSPEPYDDDAYSYSCDSDVTSIVRGEDEEDDEEVEQKSRSQRSEEILKYRLDNGLICRQVPVKETNELIRGEDEDGNKMINEYVRVCKIGAGSYGKVVLYRSTVDGKDYAIKAFHKSHLIRLRVAPSETAMSDVLREVMIMKILEHPNIVNLIEVIDDPETDHFYMVLEYIDGKWVYDGSGPPGALGEKTARKYLRDIVAGLMYLHAHNVIHGDIKPDNLLVTSSGTVKIGDFSVSQVFKDDDDQLRRSPGTPVFTAPECCLVSGVTYSGRAADTWAVGVTLYHMILGQYPFLADTLQDTYDKIVNNPLTIPDGLNPLLRDLIEGLLCKNPSERMTLKNVLEHPWVMEEEGHVPEYICCCKRRNSALKIEQEEEEEANGISNISDAS
The following text describes a protein:
Function:
May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
Sequence:
MELTLNNVETVLDELRPYLMADGGNVEVVELDGPIVKVRLQGACGSCPSSTMTLKMGIERKLREMIPEIAEVEQVL
The following text describes a protein:
Function:
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
Subcellular Localization:
Cell projection, cilium, flagellum.
Sequence:
MGRDYYAILEITRSATDKDIKKSYRRLALKYHPYTNSELGAPEKFNQLAEAYDVLSDPRKKATYDKFGEEGLKGGIPPEFGGSGAWTTGYTYHGNADKVFREFFGGDNPFSDFYTEDGGEVNTGFGGLRGRGVKKQDPPIERDLYLSLEDLFYGCTKKIKISRRVMNEDGHTSSIKDKILTIDVKPGWKEGMTITFTKEGDQGPNNIPADIVFVVKEKKHPRFSRHQDDLIYTSHIHLEKALIGCAVDVETLDGRLINIPINDIVHPKYTKVVPSEGMPLTKNPSLRGNLVIQFEIHFPEKLSPEKKGLIKQALTIYVVYSA
The following text describes a protein:
Function:
Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequence (EGRbox) TATGCATA. Acts as a major regulator of cell wall dynamics and plays a role in interactions with extracellular matrices. Required for TOR1-dependent cellular aggregation and adhesin expression. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections. Contributes to virulence by regulating hyphal formation and the factors that enable C.albicans to invade and injure endothelial cells. Required for the formation of thick-walled big resting spores called chlamydospores, which survive in unfavorable conditions. Mediates the expression of virulence factors SAP4, SAP5and SAP6 during infection. Involved in drug resistance by regulating the expression of ERG3.
Subcellular Localization:
Nucleus.
Sequence:
MSTYSIPYYNQMNGNYNNGMPQQTTAANQQAFPQQQQPTTTGNASQQQQQAAATAAAAAVQQPYNYMFYQQQGQPGQQTGQTAGQQQQQQQQQQQYDYNTYNRYQYPAATSQGNYYQQTIPNQLSQPQPQHYNGSNRNYTSAPSGAPIPSNSTSGPSQQPPLPGQQAVPIPPHVSTMQQPTPVQDTLNASSTSTVGQFQPPGIRPRVTTTMWEDEKTLCYQVDANNVSVVRRADNNMINGTKLLNVAQMTRGRRDGILKSEKVRHVVKIGSMHLKGVWIPFERALAMAQREQIVDMLYPLFVRDIKRVIQTGVTPNAAAATAAAAATATSASAPPPPPPPVAAATTTAATAISKSSSGNGNSISATSGGSNVSGASGAGSTTSPVNTKAATTAGTPQGNYYQTYNQQQYPQQYGQYNAPGKNQNTPASQPGSTTNDQYLQQQQQMYGYQSNYYQGGAANSSYYPNYYQQQQPNYASSYPYQQQQQKQQQQQPNQQQQSDQQQTSTPSGGAGTRSVHQSPQVQSLTQGSVHPSPQQHQANQSASTVAKEEK