lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem. The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide. A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance.
Subcellular Localization:
Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MQPTGREGSRALSRRYLRRLLLLLLLLLLRQPVTRAETTPGAPRALSTLGSPSLFTTPGVPSALTTPGLTTPGTPKTLDLRGRAQALMRSFPLVDGHNDLPQVLRQRYKNVLQDVNLRNFSHGQTSLDRLRDGLVGAQFWSASVSCQSQDQTAVRLALEQIDLIHRMCASYSELELVTSAEGLNSSQKLACLIGVEGGHSLDSSLSVLRSFYVLGVRYLTLTFTCSTPWAESSTKFRHHMYTNVSGLTSFGEKVVEELNRLGMMIDLSYASDTLIRRVLEVSQAPVIFSHSAARAVCDNLLNVPDDILQLLKKNGGIVMVTLSMGVLQCNLLANVSTVADHFDHIRAVIGSEFIGIGGNYDGTGRFPQGLEDVSTYPVLIEELLSRSWSEEELQGVLRGNLLRVFRQVEKVREESRAQSPVEAEFPYGQLSTSCHSHLVPQNGHQATHLEVTKQPTNRVPWRSSNASPYLVPGLVAAATIPTFTQWLC
The following text describes a protein:
Function:
Functions as a downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family. Participates in the propagation of ROP GTPase signals in specific cellular responses. Is involved in pollen tube growth regulation through its interaction with ARAC11/ROP1.
Miscellaneous:
MISCELLANEOUS: Over-expression of RIC2 in tobacco germinating pollen reduces pollen tube elongation.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MDRNGANMLDGRVESDAKGSFRKDYTKMENNNNGANISDGIYRIIRSFKSFSHFFIRYEEETKEREAEMEIGFPTDVKHLSHIGVDGTMTTFDNTSSSFPFSGFHLTGTVV
The following text describes a protein:
Function:
RNA-binding protein that functions in both mitochondrion and nucleus. In mitochondrion, it is associated with polysomes and may play a role in translation. Required during embryogenesis. In nucleus, might be involved in the regulation of its own gene expression.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Note=Can localize to both mitochondrion and nucleus.
Sequence:
MPPSLPSLQLRRLLLRSFISSSSVNTLQSQPRIISSKPLFSPLPPSRSSIFSTFPSRFFSSETNAESESLDSNEIALSFSKELTGNPDAESQTISQRFNLSFSHITPNPDLILQTLNLSPEAGRAALGFNEWLDSNSNFSHTDETVSFFVDYFGRRKDFKGMLEIISKYKGIAGGKTLESAIDRLVRAGRPKQVTDFFEKMENDYGLKRDKESLTLVVKKLCEKGHASIAEKMVKNTANEIFPDENICDLLISGWCIAEKLDEATRLAGEMSRGGFEIGTKAYNMMLDCVCKLCRKKDPFKLQPEVEKVLLEMEFRGVPRNTETFNVLINNLCKIRRTEEAMTLFGRMGEWGCQPDAETYLVLIRSLYQAARIGEGDEMIDKMKSAGYGELLNKKEYYGFLKILCGIERLEHAMSVFKSMKANGCKPGIKTYDLLMGKMCANNQLTRANGLYKEAAKKGIAVSPKEYRVDPRFMKKKTKEVDSNVKKRETLPEKTARKKKRLKQINMSFVKKPHNKMRRRM
The following text describes a protein:
Function:
Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
Subcellular Localization:
Secreted.
Sequence:
MGCYGKYAAVTLTILSVFLHLLHAFPDGEFLMQGCPECKLGENRFFSKPGAPIYQCTGCCFSRAYPTPMRSKKTMLVPKNITSEATCCVAKAFTKITLKDNVKIENHTDCHCSTCYYHKS
The following text describes a protein:
Function:
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane. Nucleus, nuclear pore complex.
Sequence:
MTTIRQRIDTQHRDAIHDAQLNIYGNRLATCGSDRLVKIFEVRPNGQSYPLIELSGHNGPVWKVSWAHPKYGGLLASAAYDKKVIIWQEINGRWQKSYEWACHEASTTSVAFAPHQYGLWLASSSADGDIGILRYDSVTGQWQSSKIQKCHEQGVNSVSWAPGSADPTAKKRLVSAGNDKCAKIWVFQQTNGFWRKLLNGHTDFVREAAWCPVTNKGQHSIVSCGLEGNLVLYRNSNIETDEWKSKLLEKSPCPLYHASFSPCGSFLSVSGDDNMITIWRENLQGQWIKVPRENKEREGMTAAGQSNGSQR
The following text describes a protein:
Function:
Required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis. Acts indirectly in a process facilitating homologous recombination. Acts during mid- to late-horse-tail period.
Subcellular Localization:
Nucleus.
Sequence:
MAKAKEVKAKPIKGEEAEKLVYEYLRKTNRPYSATDVSANLKNVVSKQVAQKALEQLRDTGLIHGKLYGKQSVFVCLQDDLAAATPEELAEMEKQIQELKDEVSVVKTLYKEKCIELQALNNSLSPAEIREKIQSIDKEIEETSSKLESLRNGTVKQISKEAMQKTDKNYDFAKKGFSNRKKMFYDLWHLITDSLENPKQLWEKLGFETEGPIDLN
The following text describes a protein:
Function:
Catalyzes the transfer of the first rhamnosyl residue on p-hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O-methylation at position 2 of the sugar unit, mono-O-methyl-glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl-phenolphthiocerol dimycocerosate (also called mycoside B) during p-hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MRVSCVYATASRWGGPPVASEVRGDAAISTTPDAAPGLAARRRRILFVAEAVTLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLPFRHHAIHTIPSERFFGNLTQGRFYAMRTLRKYVEADLRVLDEIAPDLVVGDLRISLSVSARLAGIPYIAIANAYWSPYAQRRFPLPDVIWTRLFGVRLVKLLYRLERPLLFALQCMPLNWVRRRHGLSSLGWNLCRIFTDGDHTLYADVPELMPTYDLPANHEYLGPVLWSPAGKPPTWWDSLPTDRPIVYATLGTSGGRNLLQLVLNALAELPVTVIAATAGRSDLKTVPANAFVADYLPGEAAAARSAVVVCNGGSLTTQQALVAGVPVIGVAGNLDQHLNMEAVERAGAGVLLRTERLKSQRVAGAVMQVISRSEYRQAAARLADAFGRDRVGFPQHVENALRLMPENRPRTWLAS
The following text describes a protein:
Function:
Synthesizes trehalose 6-phosphate, the precursor for the production of trehalose, the main carbohydrate storage reserve of the dormant spore. Trehalose accumulates in both prestalk and prespore cells and then is rapidly metabolized during terminal differentiation of stalk cells, while being stored in spores, where it serves as the principal energy and carbon source for germination.
Sequence:
MTIIQRSTSLNNIINEKLGKIIVASNTLPITVTKFNETPLFGSPLSASRESITSSFGMSEPSRDRESKIQIQINGHPFPTQSALETLKAKDEIEDWLWIGWSHCEVNEDEEPMLNQAIKEFSPHFEHVFLNPRQFENYYKGYCKNGLWLLLHYQMNFIRMQSEWWEEYVGVNQMFAEKIASVWRPSDIIWIHDYHLMLVPQMLRQLLPPEASIGFFFHAPFPSYELFRILPNRKELLKGILSSNLIGFQSFEYVRHFKSSCARLLDLEVHPKGLEIFEDGSTHFTKLQVYPIGVDYNDFAKNLNLPEVSSRVESLRKIFKGKKVVVARDRLDQIEGVPRKLEVFEQLLNDHPEYIGKLVFIQIYEPTVEEGDETDEQKILHKTVNEMVGRINGKFGKLSFNPIEYINKKISYEELSALYKLADIALITPIRDGMNLTSHEYVVCQKDNFGVLILSEFAGAARCLGGSIIVNPFSKKEIMEAIIEALNMSMHDRKLKHQINYNYVLANTSSFWGKRFLCDLNEATQKEIMETSVPRANFQEIEDSYKKAKVRVFFLDYDGTLTPLVRLPSQAMPSKQLIDVLSKLTEDRRNEVYVISGRDRSSLEKWLGHLPIGMSCEHGVFTRQPGENQPWTESPNAEVQWKDTVLSIMQDFEDRTPGSMTETKQVNITWHYRNADPDFGQFQAKELIAQLRSVANKYPLDILSGKKAIEVKPIGINKGEIVKMILQKIDADFILCIGDDKTDEDMFKALYNVPSFTIRVCGDLEESTKARGVVESSSEVLTLLNRLSLS
The following text describes a protein:
Function:
tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. The proposed mechanism is the following: (i) recruits S-adenosyl-L-methionine and cleaves it to generate a 5'-deoxyadenosine radical (5'-dA) in the radical S-adenosyl-L-methionine (rSAM) region, (ii) hydrolyzes acetyl-CoA in the N-acetyltransferase domain and (iii) an acetyl radical is formed by the products of the two domains and (iv) is transferred onto the C5 position of uridine(34) in the bound tRNA molecule. Does not show protein lysine acetyltransferase activity.
Sequence:
MKEKLMRCIIERILKEYKEGKTLDKKRIEQIKSECLRIYRIGIGHPSNSEILKYATEEEKKILIPILRKKPVRTISGVAVVAVMTSPAKCPHGKCIFCPGGLDSVFGDVPQSYTGREPATMRGLMFNFDPYLQTRARIEQLEKVGHPTDKIELIIMGGTFPAREIEYQDWFIKRCLDAMNERESKSLEEAQKINETAKHRCVALCIETRPDYCSEKEINQMLKLGATRVELGVQSIYNEILKLCKRGHSVEDTIKATQLLKDSGLKVSYHLMPGMPGSSIEMDKKMFKEIFTNPDFMPDMVKIYPCLVIEGTELYEMWKRGEFKPYREEEAIEVISYAKSIMPKWVRTSRIQRDIPATVIVDGVKKSNLGELVYKYMEKKGLRCRCIRCREVGHVYYKKGILPDPEHIKLVREDYEASGGTEIFLSFEDVKNDILIAFLRLRDPYKPFRKEIDDKTMLVRQLHVFGWEKALTRDIKEVSWQHMGYGRMLMKEAERIAKEEFGKKKILVTSGIGVREYYRKLGYKRVGAYMGKEL
The following text describes a protein:
Function:
Mediates resistance to o-dinitrobenzene, calcium and zinc.
Miscellaneous:
MISCELLANEOUS: Present with 386 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Peripheral membrane protein. Note=Membrane-associated or associated to a complex that cofractionates with plasma membrane.
Domain:
The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase and important for resistance to o-dinitrobenzene.
Sequence:
MFSSSSRPSKEPLLFDIRLRNLDNDVLLIKGPPDEASSVLLSGTIVLSITEPIQIKSLALRLFGRLRLNIPTVLQTVHGPHKRYSKFERNIYSHFWDDFNIKSYFQNLYDNHNNGKITISSKSSTNLAALPKRKRALSTASLISSNGQTSASKNYHTLVKGNYEFPFSAIIPGSLVESVEGLPNAAVTYALEATIERPKQPDLICKKHLRVIRTLAIDAVELSETVSVDNSWPEKVDYTISIPTKAIAIGSSTMINILIVPILKGLKLGPVRISLVENSQYCGSYGGVINQERMVAKLKLKDPLKHVAQIKKKRSLNEAADEGVDTDTGEFQDKWEVRALLNIPASLTKCSQDCRILSNIKVRHKIKFTISLLNPDGHISELRAALPVQLFISPFVPVNVKTSDVIERTLKTFGPSYQVTSQHDNSFSSKNFVDDSEEDVIFQRSASALQLSSMPTIVSGSTLNINSTDAEATAVADTTMVTSLMVPPNYGNHVYDRVYGEVTNEDETSASASSSAVESQAIHNIQNLYISDSNNSNNPILAPNPQIKIEDDSLNNCDSRGDSVNNSNLNLVNSNLTISENWNNNSPSANRYNNIINAGLNSPSLTPSFAHLSRRNSYSRQTSSTSLKNDLELTDLSRVPSYDKAMKSDMIGEDLPPAYPEEELGVQENKKIELERPQILHHKSTSSLLPLPGSSKSSNNLKRSSSRTHLSHSPLPRNNSGSSVSLQQLARNNTDSSFNLNLSFTSAKSSTGSRHFPFNMTTSFTSNSSSKNNSHFDKTDSTSDANKPREEENYTSATHNRRSRSSSVRSNNSNSPLRQGTGSFANLMEMFTKRDRS
The following text describes a protein:
Function:
Essential for spore differentiation.
Sequence:
MNSKNDLFIGFFFFFYNYYYYYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIYIIVIIGLDPQQNHPSLKIPPPPSPTSPYVRRHARQHSRSNSSNSPGELTGGVEIIQQQNSINTQTSPPTSTSPNTVPPPPPTNTTTSSTTITRNSNNINNSNGGIINSSSGSNINNSSSSGVINTNINNSGGNISPTSNSLPSSNNNILYTSSGSNSGNNNNNNNTINISSGSSGINNSSNSNINNNNNNNSSSSSGIHASGSLTAIPTNTNSNSSIFHSSNSVNRINKSNYSADSLVLPPNRISQVPQSQTQPQLQISPSTSFSSQQQQQQQLQQQLQLQQQLQQQIQQQQQIQQQQNLHFTYSKTFTSGQPNTLVNLSSPPPQSKHLHVSSDHSFFNEVLTPTPVIHNSTNQNNQLLFGDSDPLSFLEYNNFINRYQPALKNNQPVSSYRQQQQIQHQIQLQQIQQQQQQQQQIQQQQLQQQQQIQQQQIQQQQQQIQQQQQQQQQQQQQQQQLQQIQPPPTIQPPPQQTTPTLRGNRSSGNLSGLNSFSLKQSTDSLTPPPNSQQSTVSSNSTPIAATPISPLTAPTSPPPPPPPPTNFNSKFNNNNNNNINNSSNNNTTVPPSPPPIIVLPKSPSSRSPRPASAPVPSAPFLVNNRVINTSSSSNISTNNTDLNLSSSSSSSPPLNISTASPSKSEDSPPTVSPSYKQQQQQQQQQQQQQQQLNNSSNSSYSPKPRSPSVSSPPPSSISPNSSPIGSPNISFHHHQQHQIPPPPPVLSNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNHTNKKEGDSSWFNMSFKFFKKKLVPSNEYRWDLRKSNSLTLNIEDKSRCSYRLPTSGSKGIAKSTQPFSSSFTYFELFITNGNGDKICFGLTTNDHPIEVYPGNYQGSYGYSGDGKCYFGTNEGRVYGPSFSSGDVVGCGYDSSSKTLYFTKNGVYLGVAAQKVNLIGLYPTVGLQNPGESVVINFFGPFSYRGAPEKPSKQSTIKDSGGSSIIPSEDLIPKEEFEVCRWSEKKNYHGKHVVVRNRTAFLPLDSPKDTIGGVRATQPFGEGFCYFEVIIDQLDKGQLSIGLANLEYPTFYHVGWMPRSYGYHNDDGRKFRWREEPGVNEGESYGSSYKKGDIIGCGLSFTSREIFFTKNGMYLGTAFSNVYGVFYPSVAFNEPGISITGVFGPPFKFSQVTLMLKNVNSTSILVPNGNNNNNSNNNNNNNNNNIIGNGKITTTTTTSTSPSSINNNEDISSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNSSNTNNNNINNTTNNNNSNSNNNNNNNNSNSNSNSNNNNINNNNNNNNNNNNIYLTKKPSIGSTDESSTGSLGGNNSSGNNNSSSGSIGNNSSIIKQRSPPHSINGPLMLPPSSTNNNNNIYSSYNSTTAGSSTTILPTLNHPIFGNTTSNNNSSSTLSVGGNNNLLGRHCQSLPITASTNHTLSSSLGVSFSSPSSSPKTSPRKIVNSSEDLGFVQTFQDQDGQPPSAWRRCGKSIKTKDDITLTIIKKKTSVAMADRPFSSNSSSTICYFEVYLEGHDKKGSITVGLSHSTYPFIKHIGREPKSYGFSSEGEKYGGSEIGEPYGPFFFFDGDSIASSCVIGCGINTSTRDIFFTKNGHYLGVAFSRVTSDPLYPSISFRGVVGGLCVATFPGGHFRFNIEDLPGISPSVWTEALGPDRQGSGFKNWAPNDVAIWLESFNYGQYRKNFRDNNISGRHLEGITHAMLKNDLGIEPYGHREDIINRLNRMIQIWNDKSPDSYPKIAIDSSDKIRWPASGGSSGGINISGGVVIGSSSGSDDGITEISSSSKNIRPYKSYTQKEIEDRNRRSTISGGEKKNKYYIDNQMDPHQIGSMDSDGLLPDFGQGPPDEKNSSKTLSNEQIRYLQQRKDEPPIAISSTGNGGSVSSTGGSSGFLTFPSSNSLTHPPQRDKPTQEFTHLPPITSNYKGITNTGQPHKSFDQPLELFPRHSAFSNNGNNGNNNNNNNNNNIKANQQQQQQSSYQQSQTQQQQQHITSTSTSTTNKWIDPFGGWETQSSLSHPPSRPPPPPPPPPQLPVRSEYEIDFNELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKMEQASQMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHLKEMEDQGVSSFASVPVQTIDTGVYA
The following text describes a protein:
Function:
Involved in normal G2/M phase transition of the mitotic cell cycle. In association with RAD53, also involved in checkpoint control in response to DNA damage.
Miscellaneous:
MISCELLANEOUS: Present with 4630 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
METSSFENAPPAAINDAQDNNINTETNDQETNQQSIETRDAIDKENGVQTETGENSAKNAEQNVSSTNLNNAPTNGALDDDVIPNAIVIKNIPFAIKKEQLLDIIEEMDLPLPYAFNYHFDNGIFRGLAFANFTTPEETTQVITSLNGKEISGRKLKVEYKKMLPQAERERIEREKREKRGQLEEQHRSSSNLSLDSLSKMSGSGNNNTSNNQLFSTLMNGINANSMMNSPMNNTINNNSSNNNNSGNIILNQPSLSAQHTSSSLYQTNVNNQAQMSTERFYAPLPSTSTLPLPPQQLDFNDPDTLEIYSQLLLFKDREKYYYELAYPMGISASHKRIINVLCSYLGLVEVYDPRFIIIRRKILDHANLQSHLQQQGQMTSAHPLQPNSTGGSMNRSQSYTSLLQAHAAAAANSISNQAVNNSSNSNTINSNNGNGNNVIINNNSASSTPKISSQGQFSMQPTLTSPKMNIHHSSQYNSADQPQQPQPQTQQNVQSAAQQQQSFLRQQATLTPSSRIPSGYSANHYQINSVNPLLRNSQISPPNSQIPINSQTLSQAQPPAQSQTQQRVPVAYQNASLSSQQLYNLNGPSSANSQSQLLPQHTNGSVHSNFSYQSYHDESMLSAHNLNSADLIYKSLSHSGLDDGLEQGLNRSLSGLDLQNQNKKNLW
The following text describes a protein:
Function:
Probably involved in neuronal development.
Subcellular Localization:
Nucleus.
Sequence:
MDRKKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDSGVFGKPKTSNKKPSIWSKQNAGVSSRAEKDAEQKLEEQKTLDKSREKLEEKAKLYEKMTKGDFLDEEVEDMYLVDFTQKIIDKRKEMEVLGATRDSRIKEERDAAVAAANDDDDEEEFSEKDIPPPQDPSEEWVDYVDSLGRSRRCMRKDLPSLLEMDKNLQGRLFVSPANEKTLLSEDMRKELQRQQWEEEEREALKKPMGPIHYEDIRENEARQLGVGYFAFARDKELRNKQMKTLEMLREQTTDQRIKRENIKEKRKAILEARLAKLRQKKMKKSKVDGTEEESRADGVVTEPSEPKSVPAPPPVAQSSKVEVIIQERKDSKPGVPHIREWDRGKDFSFGFWSKKQSELRAERDPEFAPPSNYFVGQKRTGSLSSQPWSRPGAAPSDLGHSSGQSQEPSSSHTSTPASESSPQAPTVTFQTLDDMISYYKQVT
The following text describes a protein:
Function:
Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Is highly specific to futalosine since it does not accept aminodeoxyfutalosine (AFL), or any structurally related nucleotides and nucleosides as substrate.
Sequence:
MWLLLSPTRLEAPFLEGEPFAFLAWRGLKGTGFVYLETGIGKVNAAMALAAYAARNPVEKALLFGLAGAYPGGPSLGEAVLVEEEVEADLGLKEGLAPLGFPALALGERRYFNRFPLDPGLTGELARGLGLKVAVGLTRDLVSETPEEALALARRWGASLENMEGAAFARACLALGVRGAELRALSNPAGVRDKAHWRTKEALSALARAVRRLLAEEGGARRPPG
The following text describes a protein:
Function:
Responsible for the transport of succinate and fumarate, but not malate, across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVKMVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAGLDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVGLAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLASLMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDKMERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLMLTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIATIIVAKSENEFDEAKSIEAVEGMKKMKTAV
The following text describes a protein:
Function:
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Secreted.
Sequence:
MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL
The following text describes a protein:
Function:
Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH.
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Note=Localized to the plasma membrane in inner ear hair cell bundle. Interacts with CHP1 (By similarity).
Sequence:
MAGQLRFTSGKDEDHFQHQGAVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVYNCGNLFFSPSTLLVNITDQVYEYKYQREINQHNISPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDTAAFFQSVGNFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDESLKEEPSSQQEANKLDKNMTKTESAQLFRMWYGFDHKYLKPILTHSGPPLTTTLPAWCGPVSRLLTSPQAYGEQLKEDDVECIVNQDELAMNYQEQSPSPSSPTTKLALDQKSSGQTPGKENIYEGDLGLGGYDLKLEQTRGQPQMD
The following text describes a protein:
Function:
Essential for hematopietic stem cell development through the regulation of p53/TP53 pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAIYSGIQLKLKNTRTPWPDKLKLARFAWISTQCLLPNKEQVLFDWTNHALTCFYNKKVEMPPEVVEGLWTYLDDILHSRKLHNVLSQGKTISLRLTVAQIINDRILDYTSGLRSVSFHTILSCCHGILTSPVLSVIYTAKYELLVQLLSRLCGLTSMQLRQQKYEEPLSLKAFEVLLVVLSNYLTVQKQQANSNRVFFQVTAHLLHPLLLLRHLLNTRVWTEKDDVKIRQNLSKEIRTKVDAVLQSALFLSDHLQSYKVEVSPSENEAGDRKSHIGKGLQGPLNTILTRICIHGASEEEEALFYAVKSNSLSLLFKFALDSFCRGGENKRVIFHLMAKLITALGFTDELDIDENFRASNWGICLLALENLLNSCLVGDIYNVAADRIQHGEVQFNFYRKVARLLFNNTQMGVPAWYRCLRALLALNHQILEPDLDELLSAVWVDAENMELRVRKAREALVSAVLQTYSKLRQLPKLIEELLDVVCRPAADELRPALLPEAIQKTLSQCLLDNPLRQNLEICGLILKRVQSCLLPHIQDETSDLALKVFSMSLLLHAVLFSFKTLDNSTPVPVVKQTLSLMTEMLKVVEDLLEQKLATKGPWMEKVQEVTLLLAHTWVEADALFQIHCTKYTSPSASQSSTLVDKALMLRNMDSPLGKLLQNLLALHKLKIHLLKSFSESSEMQKMAQFILNREELSVIHSLDQMWDFQFCNVNSSTYNAAHWFLVTSNLPLIAPYLDPNDRSVFAECMLKSLLQSLDASGSNLENTGISVCLISRQLLESPVLCELPEIFSALTKCIIKALFGLLDSSHMQLICPSFLTPPVENVEVKDEEMGMTPSMKRLKAIGLEMLYSVKMKSSVPLSKRQINGLLQLVKVTSVLNGYAMSYEDYLELFLTLLTLTSTIQCVEETNLSAFIELLKELFSVMASLLLAKNSQSILKVIHGSNLLEATMTTLFSRSSEGLFKSLDGPTWLSFLQSVQDFIQSLIRLIIDRKSSICLNLEKFTSFMVECNFTARVLTVDTGDLFSLQLHLVTLSALCREMMTTLGKNKQLDQALTHLLEKATAVMEPAIQAVLMGKGSCLLRQSFSVEVVTVMIRCELARASSSNDDGQEKISSMPFYRSFYQQILKELFPSPRPMDFLISSIHYLSAFHMAAEKTKVADLEDLHIEILQSIQALLSGTWMSLTDVKELEGPVKELLNQLMSNCSQEQFHLFLLMLREGLVAAKVEGGQCSEVLSAVTLIKLLACCLFPEHCSKAFWLITPQIISSLIFIIKESSKLPSLTRVLTVPGLEALTVLLRQGKAQISNPHQVIVVLGALQFVPLDSHCMEDYHSAFEAVHEALFAIIHCYPQVMLKASPTFLNCFYRLVSSVMHEGKQRSDTDRASEKDRESLLKCARLVERMYTHVASAAEDFTVLSSFMVAQYVSELQRVTLQPEIKAHLTEGIYCILDHCVEQDIKFLNTTLQMGVKEVFNELYSSYTHYHKSQRQGEEKYTV
The following text describes a protein:
Function:
Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles.
Sequence:
MVVGRVLSLLAALVAGLLLIVLTRTMLLPAFDPSAPLPSDTVKELTDNQRNFSGRLARALTFPTVSKAPHDYDREALTNFVHFLEQEFPRVHSSPLVSREVVSNHSLLLKIQGSDRSLQPYMLCAHMDVVPADPERWSRPPFAGEIVDGYIWGRGALDAKDVLMGILEAVEWMLETRTEFRRTLFLAFGHDEEVGGMDGAAAIAKILDARGVRLEYILDEGMVVLQNVFPGMLTPVAMIGVTEKGSLLCKLTARGRSSHSSLPPRETAIVNLAKALTKFHGQCHPSMFGHDTVSEMLETVAPRAPFLLRIVFANTWLFGPAISWVMSLKHELDAMIRTTTCITRVQGGVKDNIVPGEAHAFINHRIHPKQSVAEVLAHNRALVSSLPNVSLEEVMSTEPHPVSPHSPTDFGYQTIARSAGQTFPGVAVAPTMLMANTDTRHYLHLTRNIYRFSPAYVTLEEARCVHGDDERISLWNYERLVNFYLRVIVNSNADRLVPLAAPGRKAGEL
The following text describes a protein:
Function:
With ARG80, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGISSKNGPKKMGRAKTFTGCWTCRGRKVKCDLRHPHCQRCEKSNLPCGGYDIKLRWSKPMQFDPYGVPIPQNSPATTTNLSGSVDEPQYQRRNIDFVRYDEEYVYHEDMDDELTMLHTPPIEKISDNKTWIIKKFGVFKGTDKIDKQYAPRKKRNRKRVAKSLESSASISLSSLPSSSTISFPIRHIEDKLRNKGHVKTGILSANDGVPPTPNLLDYDWNNLNITGYEWISSELRDDALLSAVTLQGHHLGHTQPQEISLEENSNVVSGEEHVNAKEHGCAFEADNQGSSTLPNKAASANDKLYQQNLKLLFQKNSSNSEEPDPQALIDDVFVNIEPRSLPASDLNKITLAPPNEESRMPKSMLELTSYSSDLPPELVDIIPKTDLTVHGLARFLLNHYFNNVADKMTVVVLEKNPWKTLYFPRALMALGDLAGLGQSSNSRNALLNALLAVSCFHLQSKYPRNYKLQKYFLGLGIELRNQASNFLRLCLNTKSSIPEKYKDVLTAILSMNSIDVVWGTMADCQDHLALCEDFVESRMKLRPNISEKTKTLHRIFSFLKLIQDSTALDKVRAKEIVILPSEEDDNYKPLDTSNATTSSSEPRVDVVQEGLFREALNENDGKIHIEFVKEPITNVSADSTPSSTTPPIFTNIATESYYNKSDISKLVSKTDENIIGTDSLYGLPNSLILLFSDCVRIVRHNEYYNLTYLPVPRKFNELSLNFEKRLLKWKSEWNFHQENSEGKSFINSTAEALYHHTMSFYFSLIIYYFTMARSLNCQFLQNYVAKVLDHLNAMEELVDQKKVKIVPLIWQGFMAGCACTDENRQQEFRRWAAKLAESGVGSYWGARQVMLEVWRRRKEDEPGDNWYSVYKDWEMNLMLS
The following text describes a protein:
Function:
Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines.
Subcellular Localization:
Lysosome.
Sequence:
MIILKRNIVFLLIIIIVLGIFIATSIEIKNYKLSLNQNKNEISKNPPIWPAPFYGQFGNNSILISKEFNFTIISDSTLLLNKTLSKYYNLIFTQDNLINSSSNTLNKLNINLKSKNEILKFGFDESYKLIIKNNENSKLEGNTVYGIMRGLETFYQLIKYNFSDNSYFIENCLPLIINDKPRFPHRGVMLDTSRHFYSVDTILKVIESLSYNKFNTLHWHIIDSQSFPLSSKSYPNLINGAWSKSEIYSYHDIKRIIKYGKENGIRIQLEIDMPGHAKSWSVGYPDLLPHGWNDSTTTIKCPDYDVPLDPSSPLSLPISFGLLSEFSGTDYGYNPNYDDKSNNLFNLTVDDLFHVGGDEIEYQCWNNSKRIKDWMNENNLKTFQDVAKQFQLKIIKQLLKIGKIPVLWEDTFQLFYKDLPKDVIVEIYHDQSTAINATNNGYKIISSIARYWYLEYSYSNWIRAYNFEPTLNISKSNIHLVLGGEGAIWSESIDSSNLFQKLYPTSSAIAERLWSPIYYTNLLNAKSRLQSFRCSLLKRGINSAPLNNSSPLSAFSCYNS
The following text describes a protein:
Function:
Required for vacuolar assembly and vacuolar traffic.
Subcellular Localization:
Vacuole.
Sequence:
MPEAGSDESIPPSEVLERFDRDESDDNDTSKDSEKLKVVETDSATTKDERSSMSGHNTGDNGEEDEEEEEEEDTEPPMLKYTRITKLPKNFFQRDSISACLFHDKLFAFATHSGIIHLTEPDLTTIRTFKCHRSSIMAIHTDGEYFATASIDGTVVVGSIENASDIMAFDFKRPVHSVVLDQNYRTSKVFISGGMAGEVIVSQRNWIGTRVDTKVDRDHGPIVGIYTVDDIVFWMNDSGITFYSISSKSKLLCVPFPTDDSIRPDLYRPRVHFPEVNTIIVCWGVSVWTFKVSLANQIDRQKKLGSILTTAASSLRALPDKKVELETYFKMDCLIAGVASFKDDQLLVLGINAFNSKSGPPELKVVDMLTGEEIHNDEIISKNFQNLSLNDYHLGKYIGANTPEYYLISANDAILVKELTLEDRYTWYMENRFYFKAWEVGRFVMNDVDRLKTGLAYINQILEEKKWDEAAKMTNTIFGAFPWKSAEDAAARPFARNSWQDIIRRFFDADKVNLIAPHIPTEPQLDTAIYETVLFFYIDENSSSQLSEYSKKWPFGYYSPDILEDKLEDKLRDVEGELRREFCQALCHLYLVHKKYLPAVGHLIDMKDPEALDLLIKEDMLVTFLDRLVEIILLPYAGPVEEINNLSLGVAQTTFSKPVELLVQNRNSIPMSQIIDTFSQELQIILFLYFKGLSAVEPLMAVPYETQLVELYARFKQSELLSFLKKHSNYDIDRAIKICSQKDGYHQELIYLWGKIGETRKALSLIIDKLNDPALAISFVIDSNDSDLWHFLVSYSLDKPNFIKSLLEHRDEYGEKTLEVMKKIPPDTELDDDLRLILGNITRDNWLSLSVNKGVFKIIDDETKEVALEFLETRSRGKLFDGTII
The following text describes a protein:
Function:
Acts in defense of young plant parts against pests via the production of hydroxamic acids from hydroxamic acid glucosides. Enzymatic activity is highly correlated with plant growth. The preferred substrate is DIMBOA-beta-D-glucoside.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MRHHGQDRKRCSLSLTAHCPLPPASESETESCSLGTSGLVAQMMAPPRLLVLLLAAAALLGCARAAADTGGLSRASFPKGFVFGTATSAFQVEGAAAAGGRGPSIWDPFVHTPGNIAENANADVATDEYHRYKEDVDLLKSLNFDAYRFSISWSRIFPDGEGKVNKEGVTYYNNLIDYVLKQGLTPYVNLNHYDIPLALQKKYDGFLSPKIANIFADYAEFCFKTYGDRIKNWFTFNEPRIVAALGFDTGTNPPNRCTKCAAGGNSATEPYTVVHNILLSHATAVARYRNKYQASQKGKVGIVLDFNWYEAATNSPADQAAAQRARDFHVGWFLDPLLNGQYPKTMQDIVKERLPSFTPEQSKLVKGSVDYIGINQYTATYMADQPTPQQPPTSYSSDWHVQYIFQRNGVPIGQKANSNWLYIVPTGMYGCVNYIREKYNNPTIIISENGMDQPANLTREEFLHDASRVEFYETYLAELKKAIDDGANVVGYFAWSLLDNFEWLSGYTSKFGIVYVDFTTLKRYPKDSAYWFKNMLQASGPGSKDGAVTSGSTQAGSGVSSSNMAAAGGSATSSSPRVLLSLLVCLYLVLPSIFMLSF