lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (By similarity).
Subcellular Localization:
Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Sequence:
MSQSRTLRQKSQKYQENIEKRGVASPKKKEDGLNINPYVLGFIIFVVVGSTLLQILKGQ
The following text describes a protein:
Function:
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPSESGNQSWHPAFMPNATADIITAKPASIPIADAEPASDHELLNPPSATREEPAVGDNTTFDEERDLDVEEDGSGEDNTHHPELSDLRNALTSSLKSPGGVEMDESPSHEGIETNVAQEDKADFPTTGPSNDIKHVSTNSFARTSHEVSWGEDDEVDSEWNLSRTNTDPFRMMPKSDRTNSFPVVPPSHEQETLHTIPHSQAEDIMNEMEQSPRNVSFDEAHDGGGDFFTQHNSGDAFDEVPHDVEETQAESESGDSPDYGQSYGGDVKQEEDEESRARFEEGIPLVQSTDQAQTGTDHSILPNNEDNAEEENEFFAQVATSAPGELDVGQASLERKSTMQVMDSLQFQQDDRTLEATPELSETRDDSPEPVTNNENVPKNALDVFDGPDSEFPANLGEGIEEATGEASSEDLAAKWQAALDDEFLDDDDELLPDDDEETEDKAVDPAAFFGSDDEGFLDDTNDAINSDINGSNGHVSGFDATTEAKPRSTSNRYIPAGAAPTVQPQTNKSFAPVAPFLTDLSRSNTTPETSLPFNPAIAMGNYPVQQQQRPELPKAQSFADKAKGGYASPYDLPMEVVKPRKRVSTNQMNRGYNASAPPAPPRASSMNIPPPSAYPPQQQQKPAMNTPPVVPNTQKPKSGADSGFFEDLPILSRPKVAPRHQTTPAPASSQYIPTATTGPQQNYASISGQPYSAPIHQEATMRQPPSLQPPMQSPTMVQGLVAPERVNPYAPIPSAGQQLPTTVPSVTSRYSPAPPPLTHSTSAPAPIPQSRYSPAPPQPRSHYTPQSSAHLQSPPQSILPHLPRTSSPLAHFERSQDGRGHGAGGEVPNYDRRSSSGYEPSLRAHPLPPTREVDENDGSVPHTPVFDEHQKSFSSSAQGMNSVSQTSPSSSIAARMGRSPPKRTGSTQYTPQHPSNTLSPAQVHGFVPPPRSHTQSPGRAFGGSRLEMSIAEPYQRPASIEALSPRNAAAFTPTQPIFHAPKRSRAPSLTSYVAPTDGREHDSLQRWKGCPVFTWGVGGTMITSFPVDVPRYGMTSTTPMVVRSPGEVKVRNVKDLDPLESRLTSFPGPLKGKAKKKEVLSWLTSGIEILEQSASYLRSIRVLSHDDKRTEERLLLWKILQVFIENDGILEGNPSVEKAVRAVLSPGIDDEVGQDSPLYATGADLSGISSSSATLTRADPVDPAAVDQMRKHLLRGEREKAVWEAVDKRLWAHAMLISNTVSKELYKQVAQEFVQKEVKNVGDNTEPLAALYEIFAGNFEESIDELVPPSARAGFQMVSTSTSLGPSKDALEGLDRWRETLGLVLSNRSTDDTKALAALGKLLSGYGRAEAAHICYLFARSSSVFGGIDDPSTNMVLIGSDHLRQPFDFDRELEPVLLSEVYEYGLSLSNTSSIVASNPHLAVYKLHHAAVLAEYGHRQKALEYCESIASTITSQTRRSPYHHAQLVSSLDDLSKRLKSSPKDENGSWISKPSIDKVSGSVWATFNKFVAGDEQDTTDAMSNAESSADVGPFARIAGGTPTISRSPSVADIYGSSYNGGGALGINGILPPAQQTKASSRYAPGSTYTPQGSYEPPSSSHGSQSRASFEGGRSSGEFRRNMYEPQKQMSSESRPISQQYNQASSFTSQSAGYSPYTGGDSPYTPQTSSMEIPSAPFESPQPISYDGQQTYQPHMANHESSGSGYEPPSSTGYETPTGYNTPTGNSYEPPSSTGYEPPSYGPNSMEQPDSPISTKPKKSFMDDDDDDIPALKARPETTREKTKAEKDREADEAFRKAAEADAAKDKKPAPQKKGWGLGWFGGGKKEASTTESTQEKKAIRAKLGEESSFVYDPDLKRWINKKAGAENTPSPSATPPPPRAAGPPRSASGTVIPSATGSISMPPRSVSSASAPPRRALSGSDDSGMTVDGGLVKPPMAPAMARTQSNGSAMGGNLSGLTSTGSAPPSRPNTGMSNASSIDDLLGPPSAGGRKGTVKKGRKGRGYIDVMGDKAGGSSGSLG
The following text describes a protein:
Function:
Regulates arginine biosynthesis genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKSEHRHQLIRALITKNKIHTQAELQALLAKNDIQVTQATLSRDIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELYMEDALVWMRPVQHQVLLKTLPGLAQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEE
The following text describes a protein:
Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Sequence:
MPHQQGKGKKTTKKSKKITKKEETEEEKIIELKPKELVKEEEKSEFLQAIKKEEDGKTIGDIDNDHKFWKYEPVTGTGVIVPQKYNNPIQPDIPIEKVPKVPAPLPNENMEYCIVNIDNEKEMEEVYILLKENYVEDDDATLRFDYQKEFIKWCLKVPGYYPSWFVGIRQKDSHELIGFITGVPSSIKIYDRIVDVAEINFLCVRKDMRKFKLAPQLIKEVTRQVHLTGLFQAVYTSGTELPNVVCTTQYFHRPLNPKKLDAIGFSTCNQRLTLQRALKLYKLPEQPNSIGFRQMEEKDVDIVTEKLNRFLHTHYDLTVLFSKEMVAHTFLSRDGIIKSYVLEQNGVIKAFGAFYILPSSILNSYEYSELYIAYQYYYFYDKDVDFKQFFKDILICAVQNHCDVFNCLNISENQQYLADLLFVPGDGYLKYYLYNWACPKVEPNKLAIILQ
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MDSRGVHTPTPTSTPGLTSRSTPNLSTPDFISPSTRRQRVVINSQSPRVMTHVAENDDAAEKRERRRSRVIELTRGGIGSPISPMDRRNSLGTTQGGLTNVQLADHYTSCIKLSAENKINVKNAFGLHLIDYMSQLLKTKNRNEVTNFQVASCTLDASAKIYAYRVDAVHADAFKMLGGLGHTECANKEAGDVPAEDGEIKGKKPKKSGMSSTVENNLKNINVNNFDLEFEVDPLFKKMSATFDEGGTRGLLLNHLSCRDDSMELLFDSNAVAMATFGDKVEISRNMEQVDFSEEFLKGQHNLLERISTTQVCLPFADFKFMEKDQDFFGEVVSKQGKGEHAFDLNAETQPIEEDGPDYDIGGFDDAADGSDREIDGGDGTIEEQSMFVDGKSARMLQDANTSQPPILDGTVGSLVLALEPSEYSYFDSKLLSMWTGPEHWKLKPRSKDACKQGGDKKARQKKEPFVLVYQGIGEVEFEKQFIETKVATTLTKKTLDKYNKDSKTLPPELSYRADALFRLFGKASVMVKRQVEEDSQMDDGIENYDYNNPNDCANYCPGVEGDDSDNESAGFQDFSQASSHFNFSHDTTIHGNVSCNASMLESQTGVDGLVQAPRKVSKIGIDYARQAKRIDVRKLKGTMWNWLIKPHAPDKPKEPIHDPEDNEREEAVSGEQTFTELMQELPTMVSGQTAKNLSVPIAFVCLLHLANEKCLMIDGNDDLSELTVAQGV
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNILQSGKIDFHGQRLVDRYSTGLLVLTGLVGFFTGFTTQSIMSVLVVDAIGLAVTCLVCLPAWPIYNQNQPKWVPKEVEPSTSDNETDDEDESNVPKTPKKTSIFGFISRILF
The following text describes a protein:
Function:
Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells. Has growth cone collapse activity against retinal ganglion-cell axons.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Postsynaptic density. Perikaryon. Cell projection, dendrite. Note=Colocalizes with DLG4 at synapses.
Sequence:
MLARAERPRPGPRPPPVFPFPPPLSLLLLLAILSAPVCGRVPRSVPRTSLPISEADSYLTRFAASHTYNYSALLVDPASHTLYVGARDSIFALTLPFSGERPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIVNASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLSSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQAMAELRPQPGAGTPIFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECIANNMKLQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVESMKLYHDWLLVGSHTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCPKEPGEHPVVFEVPVATVGHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAARVVAAYSLVWGSQRGPSNRAHTVVGAGLVGFLLGVLAASLTLLLIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALGKRGSGFGGFPPPFLLDSCPSPAHIRLTGAPLATCDETSI
The following text describes a protein:
Function:
JanA and janB regulate somatic sex differentiation.
Sequence:
MLETELFLSSRVYKKENSNISYQCIINHQDDEKYVILELLPNQKTDGNGKELPNLEKRYVFASTDTEAYHSGQKDWYVSNTRELNKNAFRSPKCLGGGICTIDHQNKKIKTYGTSYGYGDPPLDILTDILNTCFPDYDLDINITSEVRELVKPKHNRY
The following text describes a protein:
Function:
Self-assembles within the capsid. Upon host cell recognition, probably forms a tube that serves to deliver DNA genome to the host cytoplasm. This tube protrudes only at the time of infection.
Subcellular Localization:
Virion.
Sequence:
MFGAIAGGIASALAGGAMSKLFGGGQKAASGGIQGDVLATDNNTVGMGDAGIKSAIQGSNVPNPDEAAPSFVSGAMAKAGKGLLEGTLQAGTSAVSDKLLDLVGLGGKSAADKGKDTRDYLAAAFPELNAWERAGADASSAGMVDAGFENQKELTKMQLDNQKEIAEMQNETQKEIAGIQSATSRQNTKDQVYAQNEMLAYQQKESTARVASIMENTNLSKQQQVSEIMRQMLTQAQTAGQYFTNDQIKEMTRKVSAEVDLVHQQTQNQRYGSSHIGATAKDISNVVTDAASGVVDIFHGIDKAVADTWNNFWKDGKADGIGSNLSRK
The following text describes a protein:
Function:
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (By similarity).
Subcellular Localization:
Nucleus matrix. Nucleus. Lysosome membrane; Peripheral membrane protein. Note=Predominantly nuclear, but not exclusively, inner nuclear matrix. Recruited to lysosomal membrane in response to amino acid deprivation by the RagA/RRAGA-RagB/RRAGB complex.
Domain:
The UIM domains bind ubiquitin and interact with various E3 ubiquitin-protein ligase, such as STUB1/CHIP (By similarity). They are essential to limit the length of ubiquitin chains (By similarity).
Sequence:
MESIFHERQEGSLCAQHCLNNLLQGEYFSPVELSSIAQQLDEEERMRMAEGGVSSEEYRTFLQQPSVNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLGIDPINEKSFICNYKEHWFTVRKLGKQWFNLNSLLMGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQVQRPKLIGEETAQSRDQRLPRSDVDQAIEVSHPFDGTGMLDEDEENFQRALALSRQEIDMEDEEADLRRAIQLSMQGSRQSEFSNSLPQNASQPPHTSQTDSLSSEDLRRRRQAYFEKQQQQLQQQDLTLNLHDKPTINSSTLEADPGGDMSEEDMLQAAMNMSLESARNHLSTEEKK
The following text describes a protein:
Function:
Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface.
Miscellaneous:
MISCELLANEOUS: Present with 6490 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MLKNFKLSKRDSNGSKGRITSADISTPSHDNGSVIKHIKTVPVRYLSSSSTPVKSQRDSSPKNRHNSKDITSPEKVIKAKYSYQAQTSKELSFMEGEFFYVSGDEKDWYKASNPSTGKEGVVPKTYFEVFDRTKPSSVNGSNSSSRKVTNDSLNMGSLYAIVLYDFKAEKADELTTYVGENLFICAHHNCEWFIAKPIGRLGGPGLVPVGFVSIIDIATGYATGNDVIEDIKSVNLPTVQEWKSNIARYKASNISLGSVEQQQQQSITKPQNKSAKLVDGELLVKASVESFGLEDEKYWFLVCCELSNGKTRQLKRYYQDFYDLQVQLLDAFPAEAGKLRDAGGQWSKRIMPYIPGPVPYVTNSITKKRKEDLNIYVADLVNLPDYISRSEMVHSLFVVLNNGFDREFERDENQNNIKTLQENDTATFATASQTSNFASTNQDNTLTGEDLKLNKKLSDLSLSGSKQAPAQSTSGLKTTKIKFYYKDDIFALMLKGDTTYKELRSKIAPRIDTDNFKLQTKLFDGSGEEIKTDSQVSNIIQAKLKISVHDI
The following text describes a protein:
Function:
Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation. Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAEGEGYFAMSEDELACSPYIPLGGDFGGGDFGGGDFGGGDFGGGGSFGGHCLDYCESPTAHCNVLNWEQVQRLDGILSETIPIHGRGNFPTLELQPSLIVKVVRRRLAEKRIGVRDVRLNGSAASHVLHQDSGLGYKDLDLIFCADLRGEGEFQTVKDVVLDCLLDFLPEGVNKEKITPLTLKEAYVQKMVKVCNDSDRWSLISLSNNSGKNVELKFVDSLRRQFEFSVDSFQIKLDSLLLFYECSENPMTETFHPTIIGESVYGDFQEAFDHLCNKIIATRNPEEIRGGGLLKYCNLLVRGFRPASDEIKTLQRYMCSRFFIDFSDIGEQQRKLESYLQNHFVGLEDRKYEYLMTLHGVVNESTVCLMGHERRQTLNLITMLAIRVLADQNVIPNVANVTCYYQPAPYVADANFSNYYIAQVQPVFTCQQQTYSTWLPCN
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between GTP and AMP. Has very low activity with UTP, ITP, CTP and IMP and no activity with ATP, GMP, CMP and UMP in vitro.
Subcellular Localization:
Mitochondrion.
Domain:
There is a putative zinc finger domain which may bind to iron.
Sequence:
MRIVLFGAPGVGKGTFAEILSKKENLKHINVGNILRNEIKKESNIGKEVQNVVRSGNLVSDSLIINIVHDEMKNILNKKYKGFILDGFPRNMYQSKELIKMTNIDLFVNIYLPRNILIKKLLGRRICNICDKNFNVSNIQQDSFDMPPILPSKDCIQCNGHTNLIKRKDDNEDIINHRLNSYESDYIPIIQFFKNEKYNLIDFPLRRGIRDFDDFYSILVNYRKNEKLK
The following text describes a protein:
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Sequence:
MRALRCVRRGVYRQSVRLCYFMSLECSLRPITGASARLLCRFTAPTWPRKNEVEEGDVGTTESTSQDVRSIFRSNIETHSEVSLESSASPALPPKTAALDVSVLDSKGNAVPVNPVKLFSDLDNLPDWLSKGLQSSGFSCTTPIQSYTIPVLDEGHDMIGLAPTGSGKTVAFAVPALKKFQWSPNGSPRIVVLAPTRELVQQTAKVFHQLSSGKVRVCEAYGGAPREAQARRLHNGCDVLVACPGRLKDFLQNGDVIFDEVSFLVFDEADRLLDMGFKVQLDDILGYFSSHRPAQTMMWSATWPPVVEQLAQEYLSQNRYVIRSGTAGTGLQVNENIKQHIFFADAPEERVKTLVSLIKEGKIDENTAKMMIFVERQTDTENAAYALARMLGIHSRCIGVVHGGMQQRQRDHIMGIFKEGRIRILVATDVASRGLDFPDVTCVVNLIAPKNIDSYCHRIGRTGRAGRTGESFTFIGRSDGSLAKDLINYLEKCGMDVPQRLVEFAEEHAQGEEIKRMKRPWRGRQQREGRSQSRGGREPAPRDSGW
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAEDKDLMPAKYDVNAKWDACLDLTVRRFVYSSMAGAFGGLLFFRSPVTRWAAVAFGAGIGIGSAYTDCSRIFDGSSATLAPPKLADAPAPQVICFFFSQAPIFCFLIWVIWDNWTEWSFVAKIWVDSTILKDVENLD
The following text describes a protein:
Function:
Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).
Sequence:
MEIPVIEPLFTKVTEDIPGAEGPVFDKNGDFYIVAPEVEVNGKPAGEILRIDLKTGKKTVICKPEVNGYGGIPAGCQCDRDANQLFVADMRLGLLVVQTDGTFEEIAKKDSEGRRMQGCNDCAFDYEGNLWITAPAGEVAPADYTRSMQEKFGSIYCFTTDGQMIQVDTAFQFPNGIAVRHMNDGRPYQLIVAETPTKKLWSYDIKGPAKIENKKVWGHIPGTHEGGADGMDFDEDNNLLVANWGSSHIEVFGPDGGQPKMRIRCPFEKPSNLHFKPQTKTIFVTEHENNAVWKFEWQRNGKKQYCETLKFGIF
The following text describes a protein:
Function:
Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular Localization:
Cytoplasmic vesicle. Secreted.
Sequence:
MGLRKPTSLVLALCCILLIGSAVAREGLMENRKILPLLERLESSAGAGGGNCWSALFKLSSCTNEIILFFVNGESYLGMECCRSIRIITHQCWPSMLSSVGYTAEEGDILRGYCDATTIDADAAAPTRII
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane; Mediates sugar transport across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MISPLEFLECMAIVSTIGLFLCGLPICLSIYRKGDSSGTNPAPFLITTLSTSLILQYGILRKDKVVITVNSVGATLQLSYLLFYYLFTNGRLEKRRLRHLMMGEALFFVIVLYLIHYGELLHPESFLGSICVILNVSSIASPLASLKQVIERKDSSSLPFPLCAANFFVSLQWCVYGYSIGDPVIYTPNVLGTVLGLIQLTLIRMYPSKEIILSESKSSLII
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDANFKMIWEVDPKAAGRLNDIAKSLKNADRLILATDPDREGEAISWHVLEVLKEKRALKDQKIERVVFNAITKQAVTDAMKHPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVAREYWSLVATLLTPRGDAFEARLVGADGKKIQRLDIGTGAEAENFKKALEAAAYAVTAVDAKPARRNPQAPFTTSTLQQEASRKYGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDPSAITQARKVIGEDYGNAYVPEAPRQYQAKAKNAQEAHEAIRPTDMSRRPDSMSRKLDSDQARLYELIWKRTIASQMEAAELERTTVDITAKAGGRTLELRATGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSAGDGLKRQSLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLHGEDKGRVVVAFLESFFSRYVEYDFTANLEEQLDRISNNEISWQQVLKDFWNGFIGAVDEIKDLRVAQVLDVLDDMLGQHIYPPRADGGDIRQCPSCGNGRLNLKAGKFGAFVGCSNYPECRYTRQLAADSEATADRSLGQDPDTGRDVWVKAGRFGPYIQLGEQKDYEEGEKPKRAGIPKGTSPGDVELELALKLLSLPREIGKHPETGQPITAGLGRFGPFVKHEKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKAIGDHPTLGTVTVKSGRYGAICHRRRRQRDDPGRVRKGHRHAAAGDRTD
The following text describes a protein:
Function:
Required for viability in the absence of the kinesin-related CIN8 mitotic motor. May be a dynein intermediate chain.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MERLKQLEEKRRQLKELRERRKQASLFPGSETMGHHPTEVHAKATMVSVSVQTDMEEGSKIQEPQSAYLRRKEVITYDKGIQTDQIEEEQLQENENHTTTDAVAIETTAADENNKDKAENDQPRLELAKPFLVEEAAATLSNASFARLETEVSASGQQAPSNMQQDKDNLMQWNMVSENLQSETDCDCIAQEYDPGKGVLVVVYLRLPPADLQYASSEAAWSVVNVVKCDNASGRNGLLIDMVEFRGTRIMTATILRRYHPESNVISILLATLTGKIILYELRLKQKKPETPVVYVVQRNMVARHYFQHPVVAVIETSSVQDQERVLVAADNGNIMELSCLDLTVLRKPQQLRPVPLSQLLSLENDTCTYTERLQRLAKFDEVGIACMAYTSEDPQYVWIGGEDGGIYKVFWDQPGPLYLSLDNNGFQPAENHSTRVTGLEFHWDDARRLMLLLSCSTDWTVRLWDARAGKAIIGAPLLLGGPVLRARWLEKNNGGENSRTLRCQVWCADGRLVVVNWAFDAKTSLYTATVIS
The following text describes a protein:
Function:
Zinc transporter which regulates intracellular zinc levels. Required for spermatogenesis in both hermaphrodites and males where it resides in an inactive form in immature sperm, spermatids, but is likely activated in response to reduced spe-4 and spe-6 function. Upon activation, mediates the release of zinc from internal stores in spermatids into the cytoplasm. The resulting increase in cytoplasmic zinc levels promotes spermatid activation and subsequent differentiation into mature motile sperm that are capable of fertilization.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Note=Localizes to membranous organelles.
Sequence:
MRLQLVALLFALVFNAFSHEHSHEHHHEGDGSEILTKVGWNDHSEELHDHHEHDHDHHDEQLIRKNHTSHREIQHSRLSTLKVWVFSLSAVVGISLAPCTLLFFIPAQHANGPFLKILLAFGAGGLLGDALLHIIPHSLSPHDHSHDHHDHNHSHKEHDHSHDHSNQLRVGTFVIAGILVFMMVEQLVRIIKGGHCHSHENGHIVADEHRHLNEHDHEHSEEKKQQVEGLKDVKASAYLNLVADFVHNVTDGLAIGASFSAGNTLGWITTLTVLLHELPHEVGDFAILVQSGFSKYQAIRLQAVTALGAITGCVFSLLVSNPGSLNNDADTSAIMPFTAGGFIYIATVSVVPELLESGDHNNLSKVAKMAQSLVHVLAICMGVGMMYIVSLVE
The following text describes a protein:
Function:
Involved in cadmium/zinc transport.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Sequence:
MEPATLTRSSSLTRFPYRRGLSTLRLARVNSFSILPPKTLLRQKPLRISASLNLPPRSIRLRAVEDHHHDHHHDDEQDHHNHHHHHHQHGCCSVELKAESKPQKMLFGFAKAIGWVRLANYLREHLHLCCSAAAMFLAAAVCPYLAPEPYIKSLQNAFMIVGFPLVGVSASLDALMDIAGGKVNIHVLMALAAFASVFMGNALEGGLLLAMFNLAHIAEEFFTSRSMVDVKELKESNPDSALLIEVHNGNVPNISDLSYKSVPVHSVEVGSYVLVGTGEIVPVDCEVYQGSATITIEHLTGEVKPLEAKAGDRVPGGARNLDGRMIVKATKAWNDSTLNKIVQLTEEAHSNKPKLQRWLDEFGENYSKVVVVLSLAIAFLGPFLFKWPFLSTAACRGSVYRALGLMVAASPCALAVAPLAYATAISSCARKGILLKGAQVLDALASCHTIAFDKTGTLTTGGLTCKAIEPIYGHQGGTNSSVITCCIPNCEKEALAVAAAMEKGTTHPIGRAVVDHSVGKDLPSIFVESFEYFPGRGLTATVNGVKTVAEESRLRKASLGSIEFITSLFKSEDESKQIKDAVNASSYGKDFVHAALSVDQKVTLIHLEDQPRPGVSGVIAELKSWARLRVMMLTGDHDSSAWRVANAVGITEVYCNLKPEDKLNHVKNIAREAGGGLIMVGEGINDAPALAAATVGIVLAQRASATAIAVADILLLRDNITGVPFCVAKSRQTTSLVKQNVALALTSIFLAALPSVLGFVPLWLTVLLHEGGTLLVCLNSVRGLNDPSWSWKQDIVHLINKLRSQEPTSSSSNSLSSAH
The following text describes a protein:
Function:
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Domain:
Binds three calcium ions (via EF-hand 2, 3 and 4).
Sequence:
MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLRVICNGKQPDMETDSSKSPDKAGLGKVKMK
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MMFASRSPESEKDAGAIGRGTSLNVLEDLSPGNLHGVMGPRNIERTAVVSPEDRKGATLIVEGIRKSFGGLHVFSDVSFTVAPGEVLGIIGPNGAGKTTLINVVCGMLRPSAGRVLLGGEDITGGPIHASSRRGVIRSFQQTNTFRNATIRENISRAVRFSRGESSAWKKLSPLVEAFGLEPYLSVQSDKLPYGLQKMLGLVLVCATSPKVLLLDEPAAGLEHRERPRIDIFVDHMRREFGCAVVIVEHDMELVRRLCPRVLVLDSGRVLAEGDPAEVLSRKDVIDAYLGAVDEEAR
The following text describes a protein:
Function:
Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT3 and more rarely with PMT2 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNKEHLLKVDPIPDVTIKRGPLRSFLITKPCDNLSSLRTVTSSKEKLLVGCLLIFTAIVRLHNISLPNSVVFGENEVGTFVSQYVNNIFFTDVHPPLVAMLYATVSSVFGYKGLFNYGNIGTEYTANVPYVAMRFFSATLGIVSVLVLYLTLRVSGVKIAVAAICAVCFAIENSFVTLSRFTLIEGPFVFFMACAVYFFRRSELYLPNSCKANKSLLAASIALGFAVSSKWAGLFTIAWAGIIVLWRVWFMIGDLSRPIGSSIKYMAFQFTCLLAIPAFIYFLIFSVHIKTLNVNGISSSFFPAEFRKTLKYNNVIKETVAEVAVGSAVSLNHVGTAGGYLHSHLHNYPAGSMQQQVTLYPHIDQNNKWIIELAEHPNENVTSFQNLTDGTIIKLRQLKNGCRLHSHDHKPPVSQNADWQKEVSCYGYEGFEGDINDDWIIEIDKKRSEPGPAQEHIRAIETKFRLKHYLTGCYLFSHPEKLPEWGFGQQEVTCAYFAREDLTSWYIEENENEISLPNPEKVSYKKMSFWQKFVAIHKFMFYLNNYMDTSHAYSSEPKTWPLMLRGIDFWNENGREVYFLGNAVLWWSVTAFICTFIIGVAVELLAWKLGVNILRDKHIINFHYQVFQYLLGFAAHYFPYFFVGQKLFLYDYLPAYYFGILAFGHALDLISTYISNKRNNTGYIVVAIFMVVCFYFFSEHSPLIYATGWSSNLCKRSKWLGSWDFYCNSLLLSDSHYELNAES
The following text describes a protein:
Function:
Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway (By similarity). In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. Regulates ubxn-3 nuclear localization during S phase.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the cytoplasm during mitosis. Nuclear localization upon nuclear membrane re-assembly is cdc-48-dependent.
Sequence:
MQAWIQQGLHGMQMGGRVGNYDQTFVVYGPVFLPNATQSKISEINYGGKILLPSSALNLLMQYNIPMPMLFKLTNMAVQRVTHCGVLEFSAPEGQAILPLWMMQQLGLDDGDTIRIESATLPKATFAKLKPMSLEFLNITNPKAVLEVELRKYACLTKNDRIPTSYAGQTLEFLVVDLKPANSVCIIECDVNLDFDPPEGYVEQPRQVTPAVTAKPPAPDASAFIGAGQKAGGSGGTGQNATSVFGGAGRRLDGKKKPSSSVSLSDGTGVSTSNAAPVANDLPAIPPVVVNEDYKPGRVSFLRYDYKRVDVLEKELREKEASKAGQPSNVFRGGNRTLRGAR