lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localized at stabilized microtubules (MTs) during interphase and to the mitotic apparatus during mitosis. Localized at spindle poles in metaphase and spindle midzone during telophase. Colocalized with Polo-like kinase PLK1 to the center of spindle midzone. Localized at the midbody during cytokinesis. Colocalized with acetylated-tubulin at MTs (By similarity).
Sequence:
MATTAAGRLFSLELLVDWVRLETGLSPCAASPAVAFRLLDFPPLLVFPPAAPGPEPQRGAISFGRGKACLLRLHPAALRRPRLRAALLQLPVGPTSAPGLVGACDILLVPSLGQRGVFALRGPEAERVGELALFYRLTELGRFSPGVPQLRGPLSPACILDSEALEVSEPRTEETSKPCTKGISARCLQCVSNARLLEGSEPCAKDTNSWSAGDSDASVVQKSWEEAVLHSKASSGDMASAPCSPAPSGKTVSSVSQDVTELDFETNTFCPPPLYYTHLTQEKTPSARVEITIEPQRNEPEDLDDIFPETKLVSPPLRPVKHTRAAVQESPPVLPNLPQTQGPGEANEAPCPPQIEQSPVNAIRQLPLLNALLIELSLLCNQPVASPTQVHPHLAWLYRGEDKGPDPSTKSTSPSESKSNKLSVRENEKLVNPQSKKNPKGKHPKIGGSPPPKVTKGRLLYGLTNTLRLRLQQTNPNMLVVHEKREQYRRSQIQAVGPKLRIPSWKGKVSSSAAESQMSPQLPADTPTDSNGKLPSLAVQSQLPPQLPGDESLDSIGSFEEGSDTSMQIRAGFDESSTTKEVKQSHAMKQEMVDQSENRTIVTALRAPVSPAGSVTPERSLRSNSFGGNWKNKVPSPGLSLQEPTVDKTVDEGKDGRQVKAISAADTSENRPTSRKSSCESISELLYRDGFTSPCYSEDFCTTENNSRSLPAPDSSTGVEHVQKGSRASKSSEARLSTRKNSSDSSSVLTPPFSAGSPVCSHKRSRALKIHDSLEEASSLSTSDFSSQWTNEKENQADPGSSKVMRKGRDSSTKLKVRAGHKSSEKSQSPRTSQVSSYEPSNLSELELKAIDDSDLADFQEEEDGLGSLRISRQCKDICELVINKLPGYTV
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFSKENIFGTVFACQVVTGVLGNSLILYFYILNFLHGHREKPIDFILTHLSLINVLLLVTKGIPRTVTLLGIRHFLGDIACKTIVYLDRVFRSLSLCSTSILSSYQAITLSSNSPVCAVLKAKASKHITASFILCWMLSLLTEGAIPIYKITLQNSSRFRNNWNLDYCIFSIYFMNTFNTILLKILYDSVWFGLTTYSSIYIIFLMQKHHKKVLHIRSTNFSPKTCPEIKATNTVVILVNSFICFHLVSSIFFALHKSQISSSWMLHVSAFMSGCFPTFCPIVLISSMSRFSTTCFFSNCRTKPPSSKIASVCKNLLDFPSLA
The following text describes a protein:
Function:
Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWRLVRPLAVFDAEGLRELGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSKGRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLDVQIKWPNDLVVGRDKLGGILIETVRTGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADAAVLLETLLVELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDGQGVLHLETAEGKQTVVSGEISLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQALGIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKPVDVIITGGGAAKVAEALPPAFLAENTVRVADNLVIYGLLNMIAAEGREYEHI
The following text describes a protein:
Function:
Plays 2 roles; promotes magnetite nucleation/formation and activates the MamE protease (Probable). Despite its near conservation of a protease-like sequence, this is probably not a protease (Probable). Required in conjunction with MamP for proteolysis of at least MamE, itself and MamP. May transport a solute that controls MamE's protease activity. May place individual iron atoms into the magnetite lattice (Probable).
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 20 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: There is a paralogous gene with partially overlapping function in the genome (amb1004, called limO, AC Q2W8L7). LimO does not encode the C-terminal TSUP domain and does not complement a mamO deletion; MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Magnetosome membrane; Multi-pass membrane protein.
Domain:
The N-terminal region is an inactive protease, the C-terminal region may have transporter activity which could activate the MamE protease.
Sequence:
MIEVGETMGELPTNKIVFCERSWKTPVSILAFLIFVTFAWGIYLLDHYDEDDNFHGADDLSVGQFLVRNIAMPHVQRLYHTVPPAVVGVGGGGVNAGPVASGAIVGTNGYVITTLHSVSKLPEISVQVATTGGIRRFPAQVVKTIPGHDLALLKMQTTEKFLHFRMADVQTVVPGQQVFAFGRNMAGAPLVRQGLVQSADAPLAVGATQITHLLRSDAVYSWEQTGGPLVNAQGDLVGINIAATGPTGKVEGFTVPAQVIVSHLQDVVRFKKGSATAPGQPQTQTVAAGSTNWWSKARAVVGGPTAIPGMGMNVVQGNVVKGNVAPSIPSGMPFIDTDHVGGAKIGGYSVADIVGLVMLALAAGVTGGMMTMGGGVLQVAGMMVFFGYGMYLIRPVVFLTNVVVYGAASLRNDKAQLVQWDKVKPLIPWGIAGVILGYFIGNAIGDSVVGILLGLFALIMAGKAVMEILQPNAGEETAESISATEAEDEMDELMALADGTSRPKASGLALPEGHARSAVLGLPMGLFSGILGISGGVIEVPLQRYVGRISLQNAIANSSVLVFWASVAGSVVAFLHGSSTGLIHWEAPVTLALVMIPGAYVGGIIGARLMRVLPVRVLKGVYAATMAAIALKMLTSV
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MPHHGWLLAVAALCLLHNGQASMYKGYKLIRFEANETVAEWLETMSDVAHDYDEKRGEERRILFDVFSEPSKIQSHADVLVAPDFLEAFLLMLRKQGVEKVIVLKKDMQKLIDEEEYTIDNRRRRRKRAGNVVDDFDAETYHEYAVMTRFMHDLALHHPTLVKVVNVSRSTENRQIIGVKISTSSIYKPAIVIDAGVHAREWVAPAVAMYIMKKLVKSAGHDHRLSKALIDFDWFIIPQVNPDGYEYSRNTDRLWRKTRSRFNGSRYCLGTDANRNWGFQWGKAGANRSPCSNIYQGAHPFSEPEIEGLKNFLTFEIPDLTIYLSLHSYGQQEAAHKAVSAIRKTSGANYTYGTIAEVMYPASGTSIDYLQDKGVPYIYGVELRPQDSTDSYGFNIPAKFIKPTGDEMLEGILAISEHALLKKKIRL
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Sequence:
MKQVSSITFGPCYGSLCFSAERPTLLRFTHYFKSHSTRAMASHIVGLPRIGPKRELKFALESFWDGKSSAEELQNVAAGLRSCIWKQLADAGIKYIPSNTFSYYDQMLDTTAMLGAVPPRYGWKSGEVGLETYFSMARGNAHVRAMEMTKWFDTNYHYIVPELGPHIRFSYASHKAVDEFKEAKALGLDTVPVLIGPVSYLLLSKPARGTEQSFPPLSLLRYILPVYKEVVAELKAAGATWIQFDEPTLVWDLDANQLHAFAHAYSELESSLSGLNVLIETYFADVTAEAYKTLTSLKGVTGYGFDLIRGEKTLDLINDGFPSGKHLFAGVVDGRNIWANDLASSLRTLQALEGIVGKDKIVVSTSCSLLHTAVDIVNETELDKEVKSWLAFAAQKVVEVNALAKALSGHKDEAFFSINAAAQASRKSSPKVTNEAVQKAAAALKGSDLRRATNVTARLDAQQKKLNLPILPTTTIGSFPQTIDVRRVRREFKDKKISEEDYVNAMKEEINKVVKLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTSNGWVQSYGSRCVKPPIIYGDVSRPKPMTVFWSSLAQGMTKRPIKGMLTGPVTILNWSFVRNDQPRFKTCYQIALAIKDEVEDLEKAGITVIQIDEPALREGLPLRKAEQALYLGWAVHSFRITNCGVQDTTQIHTHMCYSNFNDIIHSIIDMDADVITIENSKSDEKLLSVLPEGLKFGSGIGPGVYDVHSPRIPSDTELCVKIKNIIKVLENNMVWVNPDCGLKTRKYSEVQPALSNMVAAAKYNRQMLRRLD
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Miscellaneous:
MISCELLANEOUS: Present with 5800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGHKKNGHRRQIKERENQNKFERSTYTNNAKNNHTQTKDKKLRAGLKKIDEQYKKAVSSAAATDYLLPESNGYLEPENELEKTFKVQQSEIKSSVDVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCHSATYLQNEQYFAVAQKKYTFIYDHEGTELHRLKQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGLLALSRGPHVTLWKDALKLSGDSKPCFGSMGGNPHRNTPYMSHLFAGNKVENLGFVPFEDLLGVGHQTGITNLIVPGAGEANYDALELNPFETKKQRQEQEVRTLLNKLPADTITLDPNSIGSVDKRSSTIRLNAKDLAQTTMDANNKAKTNSDIPDVKPDVKGKNSGLRSFLRKKTQNVIDERKLRVQKQLDKEKNIRKRNHQIKQGLISEDHKDVIEEALSRFG
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAKLKPIVRWAQTKERLYLTLELSDVQYPSIDLTESRLLFKGYGHGAKGEDNYELEVNFLEPINPGESSHKVMERYVEFSIAKQKGREFFWQRLVDSEKRPNWLKINFDRWKNEDDTEDEKQEAEEEQKRQISNIIVEQRLKRDYDMHGDRVKQDVVRFLKKFYLVTYNGIQFILFLYIVAKIISRFIMEGKDSLAGNYDAVSDIIASCQLAAFLEVLNPAIGIVKTGVFAPFAQVFGRNLVLFMVVVPHPTLHADPVVSALFFTWSVIEIIRYPFYIVQIIGIPFEPLIWLRYTAWIPLYPVGMITEVILIWKALPLLDQTQRFSIILPNAFNFSFSFAMFLRFYLIFMIYGKEIHSA
The following text describes a protein:
Function:
After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.
Sequence:
MASKRQSPTSRNTNALYQATRPGGSSIGHASPSSGHSKSITVLGLLADLASLKGLLYVVAAIGLLTLTLQRPGSQLVNISLSTSKYQSFAHTSSQQCQHPLHSDRPSIQYALIIDAGSTGSRIHVYRFNYCKGSQPTLEDEVFEQVKPGLSSYTDPTLAAASLDSLLQTALQNVPQSLHQCTPITVKATAGLRMLKGDMSTRILAAIQTKLDKEYPFPVLQKDGVVIMEGSSEGVYAWITVNYLLGYIGTAKRHLTAAILDLGGGSTQIVFEPDMAADTNDAGHKTLPEGSHRYDLTFGGFTYHLYQHSYDGYGLRAGRQRILGVSSTTSNSNNHQPCVRKGREKDIMAIDKIPDIIGTADGFGSCSAFITTHLFDKSESSCKLTPPLRTCSFDGIYMPSLQATFPHNDMYAFSYFYDNYAEPFNATSEFLVGDLKAAAELVCKGDTLKLTDVGKQLFQENPHWCMDLGFMHQLLGTGYSLPDTRKMKTAKKIKGIETGWALGSAIQILDGLITSGGKDGACRK
The following text describes a protein:
Function:
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Sequence:
MSRLAKKPIPYPENVKVNYVEKEHKIVVEGPKGKLELNVHPDIKVTVNQQERWIKLDRPTDRSFHKAIHGTMAALVKNMIKGVTEGFTEVLEIHGLGYRAQLKGNVLELHLGKSHPDIYPIPPDVKIEVKGNEIHIHGIDKQRVGQVAAEIRSFRKPDPYKGKGIRYKGEQLKLKPGKAVGKK
The following text describes a protein:
Function:
Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types. Plays a role in the morphology of the ciliary body.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Postsynaptic cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of supporting cells.
Sequence:
MARTPGPAPLCPGGGKAQLSSAFPPAAGLLLPAPTPPPLLLLLIPLLLFSRLCGALAGSIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSTQTVAVHHPQYGFSVQGDYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAVCVAATGKPVAQIDWEGDLGEMESSTTSFPNETATIVSQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTVNYSGVYVCKVSNSLGQRSDQKVIYISDPPTTTTLQPTVQWHSSPADVQDIATEHKKLPFPLSTLATLKDDTIGTIIASVVGGALFLVLVSILAGVFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLHQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLTRFERPMDYYEDLKMGMKFVSDERYNESEDGLVSHVDGSVISRREWYV
The following text describes a protein:
Function:
Effector that is required for full virulence. Targets host NTP1 and NTP2 transcription factors and prevents their pathogen-associated molecular pattern (PAMP)-triggered re-localization from the endoplasmic reticulum into the nucleus, where they contribute to prevent disease progression by P.infestans.
Subcellular Localization:
Secreted. Host endoplasmic reticulum membrane; Single-pass membrane protein.
Domain:
The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate.
Sequence:
MRVGFVFALLVVSVIVCFNGLTSAESTVVMNNRNPDSINVPISDDITSRNLRASGEERAYAFVDKIKSLFSRPGISQKVESLQKNPAMVKNLEKAALSQKGSSKVRDWFMHMYNNSSKRDKFFILATLVMFPIGVWAVVTNYRR
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.
Miscellaneous:
MISCELLANEOUS: The name 'deflated' originates from the 'deflated balloon' appearance of mutant abdomens.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly in the nucleus.
Sequence:
MSHLTGTRVSTFNESFLNENEHDSNAVLMELDKGLRSTKQGIQCEAVVRFPRLFEKYPFPILINSSFIKLADYFVSGSNLLRFWVLRVCQQSENHLDKILNIDSFVRCIFVVMHSNDPVARALLLRTLGAVSRVIPEKQQVHHAIRRALDSHDTVEVEAAIYASSCFAAQSSSFAISMCAKISDMIESLQVPVPMKLLLIPVLRHMHHEATTASLVSRLCMDLLPKYPAQSFVVAIIDTLTQLSSRTLVGVPGQLDVLLDFMQDLRTPVRIQVLRSFNELAGRQSVHAWPKPAIKALIDRFELCTNSKEQFLFLSILLKLSECPLTCQQLLREHRVALLRLCIQCISKLDDYTTATQAMAVLSVLVAFGLKKKGSGEQVDDILHMVNLHMEGLLLCTAKRSECTRDLRRVLTYGIRITKANAEFGTSFIGIVTNSLGDKGAYPPANAELMCEALAGLCEHFQLRKYAFSTAEDLIVDENAMDTDELPPPKINPMLARLPLILHKLNTIIDQENCDQQLRSVEILSSLVLQTTMGCYLPQKVVQCFEKCLGRLNCWTLYRIARTASRYGHHYVAAHIYTKVSQIVISDHMHYFLVALSQISQAECILNYGLEYAYMRDNYAPKVAPEPLIPLMKRLEMASNLYQQALASLRAGSSPQHPCTFQLEYLKIRAQFLQTLHLAVTVKNAQVIVPPPAIAGSLAQNSRDYLQKFGHVTNQLRKLVKALKACEETYARLYKSSFDADHVTLEFLEVAEFQCALFAHIIESICYATPPEPPVFLTTGDHPETRYFAASCQRMEQMQKNLPQEPANAKTISNRHLDVIIAQIEIITKTPLCLPRYFFQILQSTQIKLSVSPQPRSATEPVNVQSGSNLVIKVEGVLQHFSKQKKHFRRVESVQLSLTSQLITPPPRSSQELPKQGANDTVTLNQIVKPQRDFLSGSFLLPISNGGHFQVTLETFVVDENGITWCTGPKSSMVVRVLEDPSKQGAPAPSTSQAVGQTRRF
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MWAPEEDYKQPLLNGNNSRVPTNGSGKYSGRHQPEHSSRKCNDILFAILFLGVIGGMIAISAIAYSKGDPSKLVPRTPFDSSNSSSETETEKYVISHLESLVAELRRDQDILIYSALLAIALGALWIQLLKSFTRFFIYFTLCIGVALVAALGIMFISLGRKESSESTQIVGYCLCACTLLLVILIVYLRKSIDLTCAMFTETCRGIQRSPSVFIVGALIVVFFLGFIAYWTSSFIYLFSIPGSTVNPFNDHSSHSGSTTSSEDLQSRFNTKIRNLMYFMIFAFLWASSFISAVFQHCVAGVVSNWYFSRDPTGKSAVGQENAFNSLGRAFTTSIGSLAFGSLIIGFIEFMQFMLQVCKNSNATNKLVVMVVSCLQCILGCIESIVRWINKFGYIYVAMHGHSFCTSTRECFDLISRNMFNAVIMDFIGGLVLLLGKIFGAAASALFTTGILYGMGKQLNPITIALSAIFAFCIFNLFTHIVGIGTDTIFVCYLEDLETNKDGNLYISPDLHELLQSKCEELNEKNKSSNV
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MSWSFLTRLLEEIHNHSTFVGKLWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNSGQPGCENVCYDAFAPLSHVRFWVFQIILVAMPSLMYMGYAINKIARLEEAKGGSAAVRTGGGGYTHRKPRKICFGANQHRGIEETEGDQEDDPMIYEVPEIEPPKRPRDPLQPTPRPKIRHDGRKRIRDEGLMRVYVLQLVTRTVLEAGFLTGQYLLYGFRVKPVFVCSGKPCPHSVDCFVSRPTEKTIFLRIMYGVTVLCLTLNVWEMLHLGIGSIYDILRRRRCPPQEDEYQLGLLGTNGAGESSVGGTGPEAGSEEGVGGDGAADYVGYPFSWNTPSAPPGYNIVVKPEQMPYTDLSNAKMACKQNRANIAQEEQQQFGSNEDNFPTGGEARVALNKDMIQQAHEQLEAAIQAYSQQHRAEEQLGDNQDDKPQSNIIQAQPQPHSQPQKERKHRVKHAKGGSSGGGSSSNSSSSKSVEGKPSVWI
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPKSGKGKKKSKPVNKDRYISKMFLRGDSVIVVLRNPLLAGK
The following text describes a protein:
Function:
Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKHDKKTGKGRLDKFYRLAKEQGYRARSAFKLVHLNRKYDLLSKARCCIDLCAAPGGWLQVAEKYMPKGSLIIGVDLNAIKPLPHVTTFVADITTPHCRQTLRQHMHDWKADLVLHDGAPNVGSAWVQDAFTQNELVLQSLKLATEFLAKGGSFVTKVFRSQDYNSLLWVFGQLFKSVEATKPPSSRNVSAEIFVVCRDFIAPKHIDPKFLDPKHVFKDIASLPTSITEPTDTSIAPTSSSTASAAAAAARLAANSHAHSNVYAPEKKRRHREGYAEGDYTLHHTASAEEFVRGQDPVLLLGNMNKIEFRNETEKGWLKSRHTTPDIIANFEDLKVLGKGDFKALMKWRLAIRLEIGLDVKADKTQDATEEVVVEPMDEEEQITEELQKLQQAKLAKTKRERKRANEKKARELLKLQLNMTVPDDLDQNDLALQGEEEIFDLEEGENEARRRGKNGGLATLVDDGEGMDLASESEEEEDEDEEDDEVLDSDEERERKTAALEGELDGLYDSYVERKKERDAKWKVKQDRLKDKNFDAWHGIQEKSDEEGSDDDDGQDDDEEGGWDVIAQKKAKYGEGDSSDSDSDAEPETEVPKKIKKVSFEKPARSEKSSGLMTSLREPELRAQRSKQAQLWFDQPVFKEVGDLAALDGDDEEEEEEDESEEEESDDEDVDMEDASESSSTLEGDDDFEIVPQAPEDDGPEWDVDDEDQDEVKKKVIQDKGLLTAEAVSLATALVNRKTTADKLIDQGFNRLSAHNKDGLPTWFLDDESQFYKPNIPITKEAVDALRARQRALDARPIKKVAEAKGRKKMKAVARMEKAKKKADGVMESEEMGDGEKARQVRRMLARAAKGKEKAKEKKIVVAKGVNKGVKGRPTGVKGKYKIVDARMRKEVRALKRIKKAGSKRR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to cdc48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MKKKSTDLYGRKNPGMQSMSGSFSSLQIALDESSSNFSTIYEPPDLSGLDAEMIVIVKNLQKRDIVTKCRALQDLIQWNDPSQFDNEQFLNALAVLFPRLSIEVERHVRLKIFVFMSVLSSALQKKLAPWLKFYITPWVMGFFDSDRAVSVSAKDSFKNLLSEEKWPHVWLKFGSTIAPIVTDVFLHEDKESLTDLRFFSNEEAESKVTRVKSSCLLTLSFLFKQTADLENLETDKKIDKQTFKSSLYENLSTLFKSDEFWSLVSSPQDGVTVSLSDLLLIILKYDKPFVTQYKEKYFKRVSRMISRLTSLTCVPMLRLLSNMISNFPNEVHQFANDSKRPLSKLFSNLITKRISLPNSGFYTSLLNLFKSIGAMQLVPSIESVDELCDAFLETANQEQRFLSTEVYDCLLNFLSFVYTDSSDPQIKDHVRDRLRTIFTRYFKGEFVLRCSTSDFDHCLQSVFDKNSDFASLWNEVLFGFFNDESMDIETIPFDSLSRNLSLTVQTVLYLKNRNFQTGNEVMSILGPCLSFLMKLSTHKNERIACLSASQLITVCHIFSDTTLIKPVKELFQKYLVNDLPSSILKLGPQSPAFTLLRDILLLLKDYADLSEPWENVANQFTVSFDELENIRVLNSLPSLFADGKLRGKISLVKTLVEYYDTAVFAIMQNPGNDWDMIRACIGSKEILVPEETIKNILFTTLEYFLTNDWVDNHLIILCASLHSLKAHLPTIFDENKSLYSLLPVILFSKPEDDGHVAAHFESIFSLLKEKALEDSGFSLKLCSEVQEWSLNKVLNGSINEKLAADKCVLVFNSFGKLPSNFFTFPASFWDAKISSCIPFFSNKLFIDQDFILGFLDLVASEPINVDMTDVGTQFVHIFHASLYTLYYVETTGCDGDALFNLTFAYLLIRIYLQNGIQSIIDVPIRDAGIFVESFECYFKGEVVKFMRDKDALTVLNELLIDDIDGKMPVLFKRFKNLSSAENTTSFSIFAAQGLTDFLIVVSNLLEMDEKHVDVVLGKLGLSSSKSPIFVSSILEGLKPLEVDSEIIQRIRFKAVNDLTGKLHSANEVSKSLLILNAATTQQITEKPLLPITRCRLFLENITNWCSESGIKSLELLPVCCFLRFMYYFLPTVFSLSGSYWNSIFDYIKYAMKMSVVDAPIVKSFELFALRLYNALSKNYEMNSDIKDCIVESNESMNYLLLKRFLFTHESTLRNSVTARMCNQYLVKLLENCPGKVVRSFQYQEFFPSLCNSNDLQMESVCMKFLREKLSHELKELTVYYMVESDYEPDVSLCPELLSLAIDFPGDPFVMVSKMEKYEHALRVYLLVWDLIFYHFEETTYNIKLSIINQLHAMDLLRPLLNTLVEILNLSYDRPINVDKYPKIDYNLMDYSSATDRIRCLAIHIYYQCLRHLSSSVRSYWSEVKNRAFTSTVESFTGYNVSPLLISASLDDVERSIESEDFQSVGDVNVKVNRNTREISFIYNVDEHKLEMAIKIPSVYPLQNVQVEGIERVGVNERQWRSWILASQSILSSQNGSITDALLVLKKNISMHFEGVEECAICYSVLSVERTLPNKRCGTCRHKFHASCLYKWFKSSNSSRCPLCRSSFTFV
The following text describes a protein:
Function:
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.
Sequence:
MRWQRTLKQPLRFAGVGLHCGEKVSIRVLPAPANSGIVFRTNSQRCAVPALIANVNARKSQLCTQLTASNGANVATAEHLMAALVASRITNAFIDFEEDCSSVELPVLDGSSVEYVDGIRRVGVEEQQDAELHYLRIKRPVQVFKQDKAAWLLPIPDQLGSSSTASHAPTLHMSVQVNFEHKQLGSTFCRFTLSSDPDATLDNFYQNVAAARTFTFEDEIQWMQANGLARGGSLDNAVVFSKHGHVLNEDGLRFPDEWARHKMLDCIGDIGLAGLPLHGYFFATSPGHALTHELLRELFKDPENYEKV
The following text describes a protein:
Function:
Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MGTMRAERGSRPDWGGGPISFYGDLELTFIDGVLLRGTALLMLAVGSARVWRLIARPHPGVKYRQDWLLMARLGCSAVFLALCAAAGATVQGDASIYWLTAASTAVAIVLQWISFMRAPVSDGVLLFYWLFEALVHVARSVNFTIRHFYEDQWPAGHRAFVFEILLVASALLVLALEAGPQKRKKPYQEIRELHSSRRRNPLEKAHIFQRITFSWMSEMMSNGYRRYLTERDLYQLPAEHDARTLSEDMEKRWQRELNKRARPSLAWVLFSSFSHKILLAVLFKICHDILAFTQPQLLRLLIKFVTEYSKARGDISAEEDVPLVRGFMLAVGMFLVSVVQTTVLQQYFLQAFDTGTDLRSGITSLIYKKALHLSNEASGTSATGDIVNLMSVDAQRLRDLTQWGNVIWSGPFQLCLCLYSLHRLLGPCIWVGVVLLLFTLPLNSYISRVLKRLQKEQMKNKDERTRLISEILNNIKSLKLYAWEIPYKEKLDYVRNQKELKTLRKMGLTTAFANFQYNIIPFLVSCSTFAVFVLTQKGRPLTTDLVFPALTLFNLLSFPLAVLPIAITSFIEASVAIGRLTNFLTAEELQRDAITREPAVKAPGGVAVALADNATFLWQRKPEYKVALKNINFRAKKSELTCIIGKVGSGKSALIQAMLGDLFRVNGSAVVRGNVAYVSQVAWIMNGTVRDNILFGHKYDAKFYQQTIKACALTVDLSILPDGDNTFVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVAKHLLQNVFGPNGLLKSKARVLTTNKITALEIADHIVLLENGEIVQQGTFSEVISDEDSAISKLVLHHGKKQNGAPTSGESSSPSSSAFEYDVVEPDLDLEKLADEELQVQDVFSLRRPSDATFKSISFAETAHEEHREQGKVKWSIYLEYAKACNPRHVVVFLCVLTLSMFLSVMGGVWLKHWSEVNTRYGYNPNVALYLGVYFMFGLGASLSTLIQSAILWIYCSIHASVYLHESMLAAVLRAPMSFFETTPIGRILNRFSNDIYKVDELLARTFSQFFANTTRVSFTIIVICVTTWQFTFFVIPLAMLYIYYQQYYLKTSRELRRLDSVTKSPVYAHFQETLNGVSSIRGYGQLDRFIHINQARINNNTSAYYPSMNVNRWLAYRLEFIGSCIIFFAATLSVFRLASGSLTSGMVGLSLSYALQITQSLNWIVRMTVEVETNIVSVERIKEYAELEPEAPQFIANSVPSGDWPKDGEIKFENYSTRYRPGLDLILRGINLHIKPHERVGIVGRTGAGKSSLALSLFRIIEAAEGHISIDGVPIDTIGLTDLRKKLSIIPQDSQVFEGTVRDNIDPTKQYTDEQIWKALELSHLADHVKGMGSDGLDTPLTEGGKNLSVGQRQLMCLARALLIPSRILVLDEATAAIDVETDKVIQDTIRSSFNDRTILTIAHRINTIMDSDKIVVLDKGTVAEFDTPENLLKKKEESIFYTLCKEAGLTS
The following text describes a protein:
Function:
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MELNSSTLFCNDTVAWTWLSSVQPPFLALISILGVLGNSLVLCVFSLQRKPCSVADVYLGNLAAADLIMVLCLPFWMVTIAQDYQWNFGQLLCKVINTAIPMNYYCSVLFLVLVSVDRYLALAKPMNRTKMRCPKWAKRICVMVWVASFILSLPNLLFRRVRFFSTLEVEACYLAYPHPAWILQRNLTRNLIGFLVPLPVISLCTFHIVKALKNRSLMIQPRVQTERKAAKLVLTVLIVFFFCWTPFQLMRLLSTLDYFQLVSGCLWEDILQIGIQLATYLGYSNSAINPFLYVIVGSHFRKRALGVFQNLLSFRRKSSSSVLTNVTVISKCGDSPKDNRVTPLTLKRVYPPLTHQIVSRSS
The following text describes a protein:
Function:
Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-serine to yield the activated serine, O-acetyl-L-serine. It prefers L-serine over L-homoserine.
Subcellular Localization:
Cytoplasm.
Sequence:
MREFIPPASRFIELPDGFAMRRGGALYGARIAYETFGSLNAARDNAVLVLTGLSPDAHAASRPDDPTPGWWEAMVGPGKPVDTDLWHVICVNSLGSCKGSTGPASTDPRTGEPYRLSFPELSIEDIADAAAHTVRALGISRLACVVGASMGGMSALALLARHPELARTHISLSGAVHALPFSIAVRSLQREAIRSDPGWLQGHYDEGEGPRRGMLTARKLGMMTYRSAQEWDCRFGRTRIGERRRADQGRFGPEFEVESYLDFHAQRFADRFDPNSYLYLSHAMDQFDLGDGGGGGGGAPGALSRMRVERALVMGARTDILFPLSQQQEIADGLSAGGADVSFLPVDTPAGHDAFLVDIERFGPPVAKFLAIVA