lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles.
Sequence:
MDCPKPKVFPVGHCCPSLGMRASEAGSGRLSVPPSISRNSAMVNEPRGNGSPGPRWEGSSSGSESSKDSSRCSTPGLDPERCERLREKMKRRMDSGDKWFSLEFFPPRTAQGAVNLISRFDRMGAGGPLFVDVTWHPAGDPGSDKETSSMVIASTAVNYCGLETILHMTCCHQSREEITGHLNKAKQLGLKNILALRGDPIGDQWEEEEGGFNYATDLVKHIRNEFGDYFDVCVAGYPKGHPEGESFEADLKHLKEKVAAGADFIITQLFFEAETFFRFVKACSEIGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQAVSLCQELLASGLVPGLHFYTLNREVATIEVLKRLGLWIEDPRRPLPWALSAHPKRRVEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFQVFAHYLSGEPNQNGYKVTCLPWNDEPLAAETSLMKEELLRVNRRGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKKYELRVNYHIVDVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLVDNEFPLDNCLWQVVEDTFELLSRPPQDKRETEAL
The following text describes a protein:
Function:
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (By similarity). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Internalizes in presence of its ligand, TAFA4.
Sequence:
NSSLPTNISGGTPAVSAGYLFLDIITYLVYAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFIFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKMGTVSCTFNFSPWTNDPKERIKVAIAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVAFIATVRIRELLQGMYKEISIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEASTQTSDTATNSTLPSAEVALQA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Sequence:
MEDTPALISCPDCQRHFPSLPELARHRELLHRSPSGRNGDEADEIPRPYRCVQCGRGYRHAGSLVNHRRTHEIGLFPCTTCNKDFSNPMALKSHLRTHVPEGRKRRRPPRHKEATSYTQGQMTTTDICRGMPGPGENWNNQANHGQSTHVWEAEPEPREASGTWEKPPGHKDGWENRTNSKESTEGWGNTSGPTEAPALPAPTSSLLSNLEQYLAESMVDFTGNERPPQSPPAEDERRYKCGQCGKTYKHAGSLTNHRQSHALGVYPCAVCFKEFSNLMALKNHSRLHAQYRPYQCPQCPRAFRLPSELLGHQQVHEGEGKELPWEEKGEPSANGHDRSQLHGTKELNASGEFSTSGEFDAGDLNEGGVEEYRPFRCTDCGRTYRHAGSLINHRKSHETGVYPCPVCPKQLFNAAALKNHLRAHLKARRSGGEEEQQQQPPPPTPLPSLMALPPEVDPEEEENPATPTTTTDHRPYKCNECGRAYRHRGSLVNHRHSHQTGEYQCSLCPRQYPNLMALRNHVRVHFKAARRNGSQGREEPLSHDGECITPGLEREDSTLSHEEECPEEQQTTQEEEDPSEEGTIDSHPEVDMAVAQICGLCGMLFDDIESLKQHGQTHQEGENNRGESSESPPRAYSCRDCGKTYRHSGSLINHRQTHQTGDFGCGTCAKHFHTVAAMKSHLRRHSRRRSKRHQLRTSGSSGGSDSKVVVTNRNESSPEGYQEKNLIVKEEEKEKTDFHKDLKVNGINMANDKLENNENCFQNNIKKDNCKLERNDCSPSNEEDKINEKRLAGKESSFLGNLITGNKGGSGDTPALVEGVHKQESVYDAISHGPETLNGWRTSGHHTCHDCGRSFHHTAGLLNHRPCHPPGIYQCSLCPKEFDSLPALRSHFQNHGPGEATSGQPFLCCLCGMIFPGRADYRQHRSQVHDSPGENQGSSEDEEEEALASNSTPLQLSEAELLNQLQREVEGLDGAGYGHICACCGQTYDDLGSLERHHQSLGSISVDGIDTIPTDMEEKEGISETTLGDNFESTVTSISQDDTSTISEACLDTMSKDGMEVVGNVDTTSELGIEGSSVEAVPESLSPAQPRPFQCNQCGKTYRHGGSLVNHRKTHQTGDFACPICARRYPNLAAYRNHLRNHPRCKGAEPQLGVIPGVESKEPEKAAEIGPLQISSEELQKELKENAVEERAIKKEPEEPSVKQEDVPPKDDGIEEGNSEEASMDRPFGCELCGRTYKHAGSLINHRQSHQTGHFGCQACSKGFSNLMALKNHRRIHAEPRRFHCGECGKAFRLRKQLANHQRVHGERRNGNSGGSRKLLSTSPSLTRDERPFHCGQCGRTYRHAGSLLNHRRSHEIGQYSCPTCPKTYSNRMALKNHQRLHSESRRRRAGRVRRGGGPRVAVRCALCGHSLPRRGSLERHLREHEETSKKELDVIKVLSQTTVKDESQVDIHEPEERSCEYELGAQVDNQTKGTQELGQDPSGLSGSPEGSGESLSWTQGKTDGWHINETPVSISGSQKHTRPGDYGLGNTCSQEDSQLKAPEPSTLEGWDSGQTQDQDNSSQSQLELRPFCCGQCGKTYRHAGSLLNHRNTHKTGHYHCQLCSKEFSNPMAAKNHGRIHTATRRFMCPHCGKAFRASRELTSHQRGHAMDQGQAPPQVEEADGQKVETKRDMEDKCVSGQGETQRASEEISESETAMKEAKEVGLKQATEEERPFCCTQCGRSYRHAGSLLNHQKAHATGLYPCSLCPKLLPNLLALKNHGRTHTDPKRHRCGICGKAFRTAARLEGHGRVHAPREGPFSCPHCPRRFRRQISFLQHQQQHKEEWTMTSTGDTQSPTARDVDLSSPLHPPP
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTGTRLAVATLTAYCGLSAASAAPPRASNGPLQALDASALFALKESADASLVWAEYERFLLSRSRVTPLLLYFSPVAECRSENEEDEDEYEHEEAQRRGVSDAAQGACMHHHKLVEAAVELTAETLSTPQLPVVRVDVRQWPEMLHYHLLSETPSLLWMPGRASGRFQRYPHVETNFLNLQVNGSLFAEQEGLQQNDLVKESVAREITAFVRLCQEHSGYLVRNARGGLSPTVPVSYGPGDEDFSGLMELIPILGFVAFVAMVVNDNREFVLGVMRTRLFWFVLCLGVIYVALSGLFHSIIHRRAWYYFGRMHGFVFVYPSSRRQFVLEGLVNGTWSFWLSLGVMSITDVTPGLRSQLAREEVIRWSLLLVVISYMALYLTFLMKYRWLA
The following text describes a protein:
Function:
May be a carrier protein for lipids.
Subcellular Localization:
Secreted.
Sequence:
MKTIICFVFVLAGAWALTKEQIDKLEPISKECRELNGISEDTILKVRRGEAVNEPKLKNHVLCVSKKTGLASETGETNVEVLRTKLRKVSENDDEVNSIIQKCVVKKSTPEETAFEIFVCLRKVKPNFSPAN
The following text describes a protein:
Function:
Involved in uptake of biotin and desthiobiotin with the concomitant entry of protons.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASEWPETSRASSVEENPKLNIPEIVESVSDSKPSLKNQFSTTVIDSSDLNVFNDGAETTVKEQEFTSSELRRLQKLRLKMDLRIIPCLWILYFLSCCLRFTVSLSFTMNTAQGHSLIQTLSGYSAHYLALGLALFYVGYIIFEVPSNLMMAFIEPRIWVSRIQLTIGVVGACHAVLGTKHGNAQSYVALRFFLGVAESGLWPGLAYYMSRWYRGKHLGKRIGWYYTAAQIAAAAVSLVSAGFQKMDGARGLYGYQWMFLIWGVVAIAQALSIPWWLPAVASKEHRKSLSSFIPLPKWMKTLSPQRIGFLTPADKSLHSRYIAEMNVGKRWQWSDLLKSCLDLRVWPFILMYFGIVGVGNGIFNYCTLIIEEINPSFSGIDISLLNAPIWLADALGIVTVMPLYDRFHKKFSFFTGSCLIIIAGLAVANYAPRAWSRYGGLLMIGFGLGPTVPICMAWCSASMAKTYGDVGVASSLALVTGLGNLGSVVTTYALYSGWPGDPTFRKSNDVCIALIGVSIIACGIEFLLDKTGFGQFNASFNNHDHEVEDEQEMTDIKPALPSSQQADA
The following text describes a protein:
Function:
Component of the cytokinin signaling pathway involved in cotyledons, leaves, and embryos development. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Relocalization from the cytoplasm into the nucleus is induced by cytokinins.
Sequence:
MEAEKKMVLPRIKFTEHKTNTTTIVSELTNTHQTRILRISVTDPDATDSSSDDEEEEHQRFVSKRRRVKKFVNEVYLDSGAVVTGSCGQMESKKRQKRAVKSESTVSPVVSATTTTTGEKKFRGVRQRPWGKWAAEIRDPLKRVRLWLGTYNTAEEAAMVYDNAAIQLRGPDALTNFSVTPTTATEKKAPPPSPVKKKKKKNNKSKKSVTASSSISRSSSNDCLCSPVSVLRSPFAVDEFSGISSSPVAAVVVKEEPSMTTVSETFSDFSAPLFSDDDVFDFRSSVVPDYLGGDLFGEDLFTADMCTDMNFGFDFGSGLSSWHMEDHFQDIGDLFGSDPLLAV
The following text describes a protein:
Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Sequence:
MAEEHFDVLTKSGEKTGVSKPRGEVHRDGDYHRAVHVWIFVETTQQLLLQLRSDDKDSWPGQWDISSAGHISAGDTSLLSAQRELEEELGVKLPKDAFEKIFVFLQECVTNDGKFINNEFNDVYLVTILHPIPLEAFTLQKEEVSAVKYVPYEEYRNFLSKEDPAYVPYDVNGEYGKLFDIIRQRCQVNTEARSLSLQKQLQRYSPVTLEAKLTELSEADQKALGLIVKAAKIMDDIFYEQVWNSNPALRDWLKDHANASKLDKLKWDYFTINKSPWSSLDENEAFLSTADSAVKLLPGATKAIAGWKGLEYRAAFPVTKPPGANFYPPDMDKMEFTLWLNGLTEEQKHAATGFFSVIKRRSEANLDASDHLASSTKKLPDSNSDLYSIPYSEIYRPFLKKASEFLQKAGDLVSSPSLKKLLHSKAEAFLSNEYYESDIAWMDLDSKLDITIGPYETYEDEIFGYKATFETFIGIRDDKATADLKLFGDNLKLLEDNLPLESVYKSTDVSAAPIRVIQLIYNSGDVKGPQTVAYNLPNDEKIVKDRGTSMVMLKNVQEAKFEHILKPIAEITISKEQRGLVDFDSFFTHTICHECCHGIGPHTITLPGGQTSTVRKELQEVHSAMEEAKADIVGLWALKFLITKGLLSKSMVESMYVSFLAGCFRSIRFGLTEAHGKGQALQFNYLYEKGAFVFHEDSTFSVDFAKIEGAVESLSHEILTIQGKGDKNAATLLLNKYCTITGPLKTALENLERVKVPVDISPTFPLAEALMN
The following text describes a protein:
Function:
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity).
Subcellular Localization:
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Sequence:
MSPLLRRLLLVALLQLACTQAPVSQFDGPSHQKKVVSWIDVYARATCQPREVVVPLSMELMGNVVKQLVPSCVTVQRCGGCCPDDGLECVPIGQHQVRMQILMIQYPSSQLGEMSLEEHSQCECRPKRKESAVKPDRVAIPHHRPQPRSVLSWDSAPGASSPADIIHPTPAPGPSAHAAPSAVSALIPGPAVAAADAAASSIAKGGA
The following text describes a protein:
Function:
Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLLATMPLSPLLTAVIETTLNTLINDDPALGRKLLRLKGKVISLHLRELNQSLTFVFSQRIDVMTGFEGQPDCYLALNLSILPQLREQANITQLIKQDKLELEGDIQLAQKFSELMTDCKPDVEEWLSRITGDVVAHSVVHGVKSIVGALKQQAHKHQNHLAQVLTEEWRIAPPPLEIAYFCDQVDDVKSHAARLEARLNQLLEKA
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm.
Sequence:
MALELYMDLLSAPCRAVYIFSKKHDIQFNFQFVDLLKGHHHSKGYIDINPLRKLPSLKDGKFILSESVAILYYLCRKYSAPSHWYPPDLHVRARVDEFMAWQHTAFQLPMKKIVWLKLLIPKITGEEVSAEKMEHAVEEVKKSLQLFEEKFLQDKMFITGNQISLADLVAVVEMMQPMAANYNVFLNSSKLAEWRMRVELNIGCGLFREAHDRLMQLADWDFSTLDPMVTKKICEFREKYL
The following text describes a protein:
Function:
Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility.
Subcellular Localization:
Cytoplasm.
Sequence:
RYRNTYEHNLCLDMLRDGFHQSFCELFNLMRQQREEQERLGPDSGLANQVLLEEDADKLDQLKYHLTTAEAAKRRGKMDHVYSSLLALAQYFEQSGDAWLSDHFYSSCLKTSLKIRGDGRRKESEANCNVGLSLEKKGDLHKAAEYFESFYNLTKGRIWQMDSGENLHSMSCENLRRVYTAISDLVTEEDVRAGIGYLLKAYEMAKESGDTRQEGLAGYRLGAAYESVGDPETALLYHNGYLEKCQQLQDDVGMGRACQALARAYEIQGDVGSAMKYLEMFVELADRAKQLPEQQKACFSLGSMYNSQGKYLDSVRMFQRAYEIAQDLHNPVITEQARIQLGIASGHVVLSGYASCMNDVNKPNIIRILDFKSTREDSF
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTTPPSTLPASNPLLTARSLVLLQLLSRILTFTLNQSLLRLASPSVFGTAAIQFDLVCSSILFLSREGIRNALLRKSDVEVEPKSQAQIHALSIAPLQLGMVVAPLITGLYLWSSSQSTTSQQGFHLSLILYVASALIELSIEPCYIQVHRSSPPKINVRVQAEGGMAIVKAIVTVTSLVGLGEGRALISFALGQVAGAIWLAVLYIKEFDWNVKSLVSAQKVAGQPRFDADTLSLAVANTGQSLIKHVLTEADRLAVARISPLDDQGGYAVAMNYGSLIARIVFQPFEESLLLYYSNSLSSAATLPLFTFTIRLSLYLSTIIQAFVPPLFPAISSLLLPRQYRDTSASSILSLYLKLYIPCLSLNGVAEAFHTASADPGEVKRQVRWMVASSGVFAGTLFVLTHLPPHYISTNGGSYQLLTPNTEECLVLASCAAMVIRIVYALCHAKRCFLLRKPNLRWLSLLPSVKIMSWACLVRVVLGLLAASGRWERGWKEWAELIGVGGLMGLATLGFIAQAEVGHMKDLRKVMKAEKSE
The following text describes a protein:
Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Sequence:
MQHAPERIRNICILAHVDHGKTTLSDSLVSANGIISERLAGKVRYLDNTEEEQVRGITMKSSAISLVYQPEPVADKEPEAPYLINLVDSPGHVDFSFDVSTAVRLCDGALVLIDAVEGVCAQTHAVIRQAWKEGIRPCLVINKMDRLIFELQFSPMEASQRLNRILEQANAVLSSMIRMDVLEKYDQETEEPKQPETGDNKQTDGDEVSADKIEFTLDDEVISKETEQMENEMLFSPSNGNVIFASATDGWAFGIGYFAALYAKKLDVPPRVMRQALWGEYYYNAKTKKIVTKPPTSNSQTMFCSFILDLIWATYTAMANPVSSDADMETLRKLTRQLRVAKLVTDRDLKQTDRKNATQVVMRKWLPLSTAVLRMVTRVLPSPVTAQVKRAEKLCTISPEQLARSPQHAQVFRSLQSCQTSEEAPLVIYICKVISVEANVLSDYHQAGLASTDEVYVGVGRVYSGVLTAGQPVYVLDPKFQGVPGDVDFDTIDPTTVKHVARIDSGLIKTYMMMGRDLHKLDRVPAGNIVGIVGLQEHVLKTATLSSTLACPSLTKMPYQAKPIVRVAVEPEDPRNFGALEAGLQRLYRSDPTVEVHVQETGEHVIVALGELHLERCIKDLKERFAKVAVQVSEPLVGFRESIVDGTISSFQENIVFKEFLSADTSKDDTPDKEYDAHSAQDPKLALGMAPDGTLTLKLRALPLPLETAKLLEESAALLKRIALSKKTANETDDNEPIVEVVAAAGDVSTFKTALEKSLQASENSFLKSLPLDQIWSCGPRRVGPNMLINNIPGYHTTGSLLASNLTEASEPISEKSEQIKKLENSIVTGFQMASSAGPLCDEPVWGVAIVIEDVVFHEKGIDENKSGEEKAEASKYGPLSGQVISIMRTTCLMAFVKQPVRLVEAVYECTVQCQAEQLGKLYSVISKRRGDIYSEELSDGTALFTVKAHLPVVESFGFATDLLIQTSGAASNPQLIFSHWSIIDMDPFFQPQTEEEREDFGERVYEHNYVRRYIEAVRKRKGLSRDEKVVVHAEKQRTLKR
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. Associated with the spliceosome throughout the splicing reactions, until after the second catalytic step.
Miscellaneous:
MISCELLANEOUS: Present with 1670 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MFSNRLPPPKHSQGRVSTALSSDRVEPAILTDQIAKNVKLDDFIPKRQSNFELSVPLPTKAEIQECTARTKSYIQRLVNAKLANSNNRASSRYVTETHQAPANLLLNNSHHIEVVSKQMDPLLPRFVGKKARKVVAPTENDEVVPVLHMDGSNDRGEADPNEWKIPAAVSNWKNPNGYTVALERRVGKALDNENNTINDGFMKLSEALENADKKARQEIRSKMELKRLAMEQEMLAKESKLKELSQRARYHNGTPQTGAIVKPKKQTSTVARLKELAYSQGRDVSEKIILGAAKRSEQPDLQYDSRFFTRGANASAKRHEDQVYDNPLFVQQDIESIYKTNYEKLDEAVNVKSEGASGSHGPIQFTKAESDDKSDNYGA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MAEFPPLLSQEDMKKHKILLAYRDRCAALLVPLNECRKKNYYMPWACGHERHEYEMCEVADFQRRVKAMDKLKAEKIEQAKAAAAAAAAAAAADAEESK
The following text describes a protein:
Function:
Probable signaling protein whose physiological role is not yet known.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIWLIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHILTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIFFDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHWSIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGDIISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFHLNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTKVLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARLGGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTDGLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQPQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQARIWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNHSKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQITGAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQPSQ
The following text describes a protein:
Function:
Pore-forming subunit of an ATP-permeable channel. In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (By similarity). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Recruited at immune synapses in response to pathogen-derived and proinflammatory stimuli.
Sequence:
MEKFKAVLDLQIKHRSALGYGLVTLLTAGGEKIFSTVVFQCPCTATLNLTYGLVFLLVPALALFLLGYALSARTWRLLTGCCSRSASTRSSSGLRSTLVCAQVSAVAALAPLTWVAVALLGGSFYQCAVSGSTRLASYLCKDRNHSCIAKLPQVPCNKQEAEMQEILSQLKAQSQVLGWVLIAAVIFLLLVFKCVSRCFSPVSYLQLKFWEIYLEKEKQILQSQAAEHATQLARENIRSFFECSKPKECNTPSRKDWQQISALYTFNSKNQFYSMLHKYVSRKEVSSSLHSVEGDVVVPVLGFVDDAAMANTHGV
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MWMYIHKIMKLSYKRVILTRELEDIKKDKPLFEREGFKVLELPLIQTKVLEFNLPDEEFDYIVFQSKKAVKIFLGKVNLKGNKKIVAVGKKTAEELEKLGYKADFIPENESAKGLIELFKRLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEYVFYTREELLEKLNKGDFIIFYSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDIVKKLKELARDLQK
The following text describes a protein:
Function:
Protects the bacterial cell from host peptidases.
Sequence:
MDRQESGMTSSGVRRMLLWVVLLTVALGSVACKRNESGQLPTASGEAIKADKQGITGFGLARAYPDQTSDGLSLALEFSRPLVGTQDFDALVRFEEKVGNGDSSWSLSDDGKTLRYPYVEAAKDYTVLIAANLLAADGSRLGKPLKQKVYTGELKPVAGFASQGSVLPARESRGLPVVSVNVPEVDVEFLRVREKSLPAFFHQFQRGGRRGSWDLENEYSENAPLSKLADPIYVNRFILGGKQNERVLTYLPTQDIKELQEPGLYFAVMKRAGTFENEFDTAFFTVSDIGLHTRAYKDKLFVHTASLQSGEPAKNVELRILDAKGELFLKGSTDANGNALLNYTLDASHVLVARSKTDISMLPFNQPALDLSEFAVAGREGAWFDVFAWAGRDLYRPGETMRVSAILRDNDGKPTSGPTKGGQPVFLRLKQPDGKTFRETKLQPGEQGYFEFTQQIPADAPTGRWQVEFRTDPGSKDAVQGMTVRVEEFLPERMKLDLDAAQKTLSAGKPFTLIANAAYLYGAPADGNRFTAKLAVSVEQHPLESLPGWFFGDPTLELPREAKDVIDTEFGGDGVLREDIALPDEAKPVSTIAAVVSGSVYETGGRTVTRTIKRVLWPAKALVGVRPLFDDTDGADANSNARFEITRVDAEGKPQPAKGLKATLVRELRDYHWNYTDDHWDYDFTRRFENKDTRTIDVGSGNAKLDFPVEWGEYRLDVFDPATGLTTRYPFRAGWSWNDENRGLDARPDKVKLALDKTGYRAGDTLKVTLTPPHAGKGVLLVESDKLLYVQDIDVKPGSTFEIPVTEAWERHDVYVTALVFRGGSAPSKITPARAVGVAFVPMDRKARRVAVGLSAPNQMRPEQPLPVTVSVPELAGKAAHVTISAVDVGILNITRFPVPDANAQFFAQRRLGTDAYDIYGRVIESFEGASGKLKFGGDMALEALPQAKRPTARVQTVDLFSGSVKLDAKGNARVQLPVPDFNGTLRVSALVYSDTRYGNRDMETIVRAPILAEASMPRVMAPGDRSTVTLDVQNFTGRPGEFNVRVDGIGPLAIAEAARSVKLATDGKQTLSFPLTATEGYSVAKVRVRVDGNGFKADRSYDLPVRAGWPQVLRTQTRVLDPLAPVSMDAGLTEGLMAGSVTARMLVSPLPPIPFASALQDALNYPYGCAEQTTSKGYAALLLDEATARALGTKGLDAATRRERMEGAFGRLASMQIASGHFSMWGDDGYVNPGLTPYIAEFLLDAKDAGFAVPDNVLQKALNRLSEDLLSGGNEFYGQDRRDNLKFANQAWSGYVLARVNRAPLGTLRALYDNQRDKALTGLSLVHLGAALSLQGDTKRGQAAIKAGFAKNSADRPPYFGDYGSAIRDDALMMALLHERGLSSPEYDTRAVTLGQALDARRGGGSLWLSTQEQVALARLGKALMVAQGKTVSGTLTVGGEAQEIAPARLFGRSFDSAALARGVQFVPQGEAPMYASLEVAGIPRSAPEADTRHLSVERTWYTTDGKPWTPRALKEGEALIVRVTITANTSMRDALLTDLLPAGLEIENFNLGDAKQWADVVVDGIGISERSSAADVKHEEFRDDRYVAALSLSSGSKAQVFYLVRAVTPGTYTVPPSLVEDMYRPDLRGVGRTNPATITVVQP
The following text describes a protein:
Function:
Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, and protein synthesis. It may also be involved in pleiotropic drug resistance. When overexpressed it confers increased resistance to cisplatin, the DNA-alkylating agents methylmethanosulfonate, and mitomycin C, the antimalarial drugs quinidine, mefloquine, and chloroquine, and increases cellular tolerance to sodium and lithium. Preferentially binds 5'-TTACTAA-3'.
Miscellaneous:
MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLMQIKMDNHPFNFQPILASHSMTRDSTKPKKMTDTAFVPSPPVGFIKEENKADLHTISVVASNVTLPQIQLPKIATLEEPGYESRTGSLTDLSGRRNSVNIGALCEDVPNTAGPHIARPVTINNLIPPSLPRLNTYQLRPQLSDTHLNCHFNSNPYTTASHAPFESSYTTASTFTSQPAASYFPSNSTPATRKNSATTNLPSEERRRVSVSLSEQVFNEGERYNNDGQLIGKTGKPLRNTKRAAQNRSAQKAFRQRREKYIKNLEEKSKLFDGLMKENSELKKMIESLKSKLKE
The following text describes a protein:
Function:
Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles.
Subcellular Localization:
[Isoform a]: Cell junction, adherens junction. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Cell projection, podosome. Note=Colocalizes with pat-3 to dense bodies, adhesion plaques and M lines in body wall muscles. Colocalizes with deb-1 in podosome-like structures in the pharyngeal muscle. Requires unc-95 for the localization to dense bodies; [Isoform c]: Cell projection, podosome.
Domain:
LIM zinc-binding domains 1-4 are sufficient for the localization to dense bodies, adhesion plaques and M lines in body wall muscles.
Sequence:
MPSDDRFADAVKPALEALLSDLQHTTEVLRRAHISDRRSQSRDDFEQSYDLQGNLNTQSVSNGNITTSPYKRRSSEGKDYSKSQERIYENESRLNPPVYSRPSVQSLLSQVEEPPIRASSSRKSLGPPSQAQSYSDVRSNGRSPSRDPLHSDSMIGTMNGELSSKHGVNTIPKGDCAACGKPIIGQVVIALGKMWHPEHYTCCECGAELGQRPFFERNGRAFCEEDYHNQFSPKCQGCHRAITDRCVSVMNKNFHIECFTCAECNQPFGEDGFHEKNGQTYCKRDFFRLFAPKCNGCSQPITSNFITALGTHWHPDCFVCQHCGVSFNGASFFEHNGAPLCERHYHESRGSICSQCRGAINGRCVAAMGRKFHPEHFRCSYCNHQLTKGTFKEVDRRPFCHKCYNNTYALTPA
The following text describes a protein:
Function:
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSDSDLPVQVKKEPSFANDDDLTFDEEFRRAGDQENKEVENPDDGRSLKRTREESEQEENNEKEQDQEAGQDEEEQDEDEEEEEDDEEEDEEDEVSSRRKRRRGANQFFDIEAEVDDEEEDEEDEDEEAELMREEFITDDHAPVETVEKMPQDDRLHRQYDNRRQQAEDQDAEQLAETLKQRYRKTHSVYRGETAASGTVSQKLLMPSINDPSIYAIRCTPGREKELVRKLYEKKRTLERQGNPLDILTVFQRDAFTGYIYIEAKRPDAIDKALVGMVNVFVRDKLLVPVKEYPDLLKQVKSSDVEIRPGIYVRIKRGIYRGDLAIVDNLSENGLDVRCQVVPRLDYGQNDEIGPDGKVIKSKIKPLPALFSEQKARMYDPYKLQMGRVPNSFIYRGNEYYDGYLYKDFKLQFIQTKDVNPTLEELDRFQNQNDEDGLNLQAIAATLKGNNAGEGKSSTAFQPGDKVEIRRGEQAKTIGIVVETALNEITIKVTDSGDPRFVDQRLTVPANDLRKIFYEGDHVRIVEGKHFDETGLVIKIDGDSVVIVSDQTKEDVRVFANYLVKATDASSNFDLLNSKYDIKDLVELSGLTVGVIIKAEKNIFDVLTTDGRLISVRQSGIASKLKQSRREQVATDRNGTTIRVGDTVKELLGEKSREGAILHIYKNALFIKSNEIVENLGIFVANRMNVTTVATKDSTVSKSLGPDLTSMNPNLRLPNPVAVAGLKTRVGGRDKLLYKDVAVTSGSYKGLKGKVTEADDLYARIELHTKSKKIKVLKNNLNVIVHGQPVPYLRFIGAAPEFSQPTPPTYGSSSGGRSAWNGGMTPSVSAGNGGVSAWGGSRGGFGGDGGKTPAYGAGGASTWGGASAWGGGAGGSSAWGGIKGAGSVWDRSKGGSSASSGNQGGNTAWDRNKGGNSTWDRSKGGSSSWESGSTWEGGNNTTWGSKKGNTSAWGRN