lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD(+) or NADP(+), forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).
Sequence:
MTGGMSAVVWAGVNDVRVEEVPMPEVPPGWALVRVACTGICGTDLGIVHGKHPRARQGLILGHEISGWVEVTAPGGPPEGALVVAEPLISCKDCRACREGHSHVCARLGLFGIDAPGGAAQFVALPTSTLHQVPSRVEPTQAALTEPLAVAVHAVSRSGMEAGDVVAVFGAGPIGILTALVARHEGASHVVVAEPNARRRAVASDMGLIAVPDGAQLRDMVAELSQGDGADTTFDSAAHPAVAAELADVTRVLGRVVIVGVYKEPAAVDLQAVCFKEQSVVGVRVYTREDFRTAIDLVAQNALGLDRFPVSVYGFDRISDAFDAAATGSGGLKVLISTHRDEAT
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MGLMYATAIPLWPNKRRPSFELLFFPSSTEGRSKRRNKMASFYRAAARQSRSPVTSSFQAAKHPVSPPRLRRSRPKYLDPDCFRSFVAVAAALASVDSLMPLHSAVAAARLRSCIAADSSYRSGLS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. A14 seems to play a role in the stability of Pol I subunit A43 and association of rrn3 to Pol I.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATECPPKMILRKSEKLDKDASSKFLNRYIQTIERFQDEKSGSESVLSQLNRVLMYLKGEEIPLISLNLPVQGPPTEELIIPPEEMLETKEEESLKHAREENDDLHLDKETKKRLKKEKKKAARREKEEARKAKADTTQGVGEKEQS
The following text describes a protein:
Function:
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MADSKEIKRVLLSPLFDNNPIALQILGVCSALAVTTKLETALVMTLAVTLVTAFSSFFISLIRNHIPNSVRIIVQMVIIASLVIVVDQVLRAYAYEISKQLSVFVGLIITNCIVMGRAEAYAMKSPPIESFMDGIGNGLGYGVILVLVGFVRELVGSGKLFGVTVLETVQNGGWYLPNGLFLLAPSAFFIIGLLIWGLRTLKPAQIEKE
The following text describes a protein:
Function:
Required for the assembly of cytochrome c oxidase.
Subcellular Localization:
Mitochondrion intermembrane space.
Sequence:
MSAPYKPTATEASPSSASSYLSSSSPRPSASASASSRAHVDDPSQPQDFVSVMSHKTPSKFTDPCAHAAKLSMKCLDDHAYDRSKCADVFHQYRQCKTAWINQRRQDRLNNRPGAFD
The following text describes a protein:
Function:
Plant specific, probable 3'-5' DNA helicase that may play a role in the repair of DNA.
Subcellular Localization:
Nucleus.
Sequence:
MDLSSDQLVMKIVEMGFEKLDALEAVKAVGGKSCDDAVEYILKGNHRTGGFKPASLLCSSGSNKILGKRAMPSSFSSSESKRQSSLLDHFRSVNQNKKKGDTFGTVEVDSQLETVSEHSEEVRKSLAPVFMESSCFPEGQLLNGCSEASSSWEKRVNSILRNRFGISSLRSFQREALSTWVAHKDCLVLAATGSGKSLCFQIPALLTGKVVVVISPLISLMHDQCLKLSRHKVSACFLGSGQLDNCIEEKAMQGMYQIIYVCPETVVRLIKPLQKLAKTHGIALFAIDEAHCVSKWGHDFRPHYRKLSVLRENFCASNLEFLEYDVPIMALTATATVNVQEDILESLHLSKETKIVLTSFFRPNLQFSVKHSRTKFASSYAKDFQNLVDLYSEKKNSTGKKLAVISRESEEQTDFGSHDSENIHETDYDEDEEDQENSLAKKNSSNGKELSEAYLEDETDIFQSVDDWDVACGEFCAMPSCELLEIPVPSEKQKDLEGLTIIYVPTRKESVNIAKYLCGVGLKAAAYNASLPKKHLRQVHQDFHDNKLQVVVATIAFGMGIDKKNVRKIIHYGWLQSLEAYYQEAGRAGRDGELAECVLYADLSRAPTLLPSRRSKEQTEQAYKMLSDCFRYGMNTSQCRAKILVEYFGEEFSSKKCNSCDVCTEGPPELVDVREEANLLFQVITAFHLQVDNDSEHAPYEDYGLGNSKQNKLSHKPNLLFFISKLREQCEKFKETDCLWWKGLARIMEAEGYIKEMDNKDRRVEIKFIQPTEKGKKQLDFQDDKPLYVYPEADMLLSLKQDRTYSGFSEWGKGWADPEIRRQRLERRERKPRRERKPRKKRTRGRSSTKLHPWRSKE
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Seems involved in the regulation of cell proliferation. Essential in leaf polarity establishment, probably having a role for translation in leaf dorsoventral patterning to specify leaf adaxial identity.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MEEPFLIREEQLVPSTRTWHRGQFTVELKKVCRLAAPMATVTSAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSGFSIMYGLAGALETLCGQAYGAKQYEKLGTYTYSAIASNIPICFLISTLWIYMDKLLVSLGQDPDISRVAGSYAFWLIPALFGQAIVIPLTRFLLTQGLVLPLLYCAVTTLMFHISVCWILVFKFGLGSNGAALSISVSFWFYAVILACYVRFSTSCEMTRTFVSDDFVSCVKQFFHYGVPSAAMLCLEWWLFELLILSSGLLPNPKLETSVLSICLTTETLHYVISNGVAAAVSTRVANNLGAGSPQVARVSILAGLCLWLIESVFFSTLLFICRNIIGYAFSNSKEVVDYVADISPLLCLSFILDGFTAVLNGVARGSGWQHIGAWNNVVSYYLVGAPVGLYLAFSHGFNGKGLWCGVVVGSAVQATILAIVTTSMDWKKQVFVKPSKSNAYFKRYQVKFRRRRDGKTDYRARIRLINQDKNKYNTPKYRFVVRFTNKDIVAQIVSASIAGDIVKASAYAHELPQYGLTVGLTNYAAAYCTGLLLARRVLKMLEMDEEYEGNLEATGEDFSVEPTESRRPFRALLDVGLIRTTTGNRVFGALKGALDGGLDIPHSDKRFAGFNKENKQLDAEIHRNYIYGGHVSNYMKMLNEDEPEKFQTHFSQYLKKGVDAETMEELYKKVHAAIRADPNPKKTAKPAPKAHKRYNLKKLTYEERKNKLIERVKALNGAAGGDDDDEDDEE
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MGRVAIVSSMVILAAVISSITSYQVKPANYAKLIEKQKKFDEAFEKEFYVEHTKYVETGEQSERLQEMFEHIRQEPDMFRMEMDNHPLPYLTAECTACRALVTTYLTYRRVLGWDRDRIALQAASTCETLNILTPPNCLKIVNKNIDILLYIIDNRPSLTAQTICGIIFQSGTCVLEDPAFLNWSINVQPGGRPITASKTSPNRGASDLKIIHITDVHYDPHYRTGYNAVCGEPCCCREGQGIPANPADGAGEWGDYRDCDSPWKAVEDAVRAAARQHPDAAYVYYTGDIIDHGVWETTVAGNIVSMTRTYQLFRDVFGSKPVYNVLGNHENNPTNVFAPSYITQSEFSAKWLYDFSADQWSTWLPTASQQTIRQGGFYTVLVRPGFRIIGMNNNDAYTFNWWILYDPAYLQAQLQWVHDTLLQAEAAGEKVHILAHIPIGAGTSYRTWARQYRRILDRFWDVITAHFHGHTHADEFNVFYSLANPQHAISAGFNGGGTVPFSNYNPNYVVYYVNPQTYDVTDFESWYFSLTEANQNPNRNPIWMQLYSFSRDFQLSNVSPASLDGLVRRFASNPAELRRYWEFKVKRGDPFIAAGCDGDCLLNHLCQIVTNEANDDTKCNALAAIFRNLDDELFNEEK
The following text describes a protein:
Function:
Stimulates the adrenal glands to release cortisol.
Subcellular Localization:
Secreted.
Sequence:
LSWKQWLKIPPLSLINFVQYVSVMPKKFSRCNLFSSNFENDWFSLVQDCVHLCMSGIKPESPDLGGSVLPPKNIDDGDLLLSIFLATLAAQDKASESDMNRRSYAMEHFRWGKPIGRKRRPIKVFASSLEEGDSSERSFPFRVRRHLTSHRNLDVPLQDRKEETYRMNHFRWGSPRTSKRNGSFRKLWEESSEENPATLLKNIIFMKDVQRKID
The following text describes a protein:
Function:
Nitrilase that acts on various kinds of nitrile compounds such as aliphatic and aromatic nitriles. Has higher activity toward aliphatic nitriles compared to aromatic nitriles. Among the different substrates tested, has the highest activity toward hydrocinnamonitrile.
Sequence:
MMDSNRPNTYKAAVVQAASDPTSSLVSAQKAAALIEKAAGAGARLVVFPEAFIGGYPKGNSFGAPVGMRKPEGREAFRLYWEAAIDLDGVEVETIAAAAAATGAFTVIGCIEREQGTLYCTALFFDGARGLVGKHRKLMPTAGERLIWGFGDGSTMPVFETSLGNIGAVICWENYMPMLRMHMYSQGISIYCAPTADDRDTWLPTMQHIALEGRCFVLTACQHLKRGAFPADYECALGADPETVLMRGGSAIVNPLGKVLAGPCFEGETILYADIALDEVTRGKFDFDAAGHYSRPDVFQLVVDDRPKRAVSTVSAVRARN
The following text describes a protein:
Function:
Involved in nitrate transport.
Sequence:
MKFSVAFVMTLMLASVSMAQASVLFSTLERTLVVEAKIKEQEISSGIALAGVSHLVISWHLNESFPVSVGDKYVNVKLRLCYAPVSQIDRGWRKTNDDLHKDKTCTKGIAQQKYIFSGNSTTWRVTKDVPGAVYFVRAYAVDAEGNQLAFGQTTDKAKTANLITVLPISGRTGNIDIAAAIFSAFSVVSLTGFLGLESMRSKRTSK
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MGMSKSIKVILSLALVVFLALAATKVEATRYITYPAIDRGDHAVHCDKAHPNTCKKKEANPYQRGCEKINRCRGG
The following text describes a protein:
Function:
Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes, such as the csgBAC operon encoding the subunits of curli proteins. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 (rpoD) and sigma-32 (rpoH).
Subcellular Localization:
Cytoplasm.
Sequence:
MTLPSGHPKSRLIKKFTALGPYIREGKCKDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAGDWKSVPVKDTEVVERLEHTLREFHEKLRELLTTLNLKLEPADDFRDEPVKLTA
The following text describes a protein:
Function:
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Sequence:
MLKIIRAGMYTTVQDGGRHGFRQSGISHCGALDMPALRIANLLVGNDANAPALEITLGQLTVEFETDGWFALTGAGCEARLDDNAVWTGWRLPMKAGQRLTLKRPQHGMRSYLAVAGGIDVPPVMGSCSTDLKVGIGGLEGRLLKDGDRLPIGKSKRDSMEAQGVKQLLWGNRIRALPGPEYHEFDRASQDAFWRSPWQLSSQSNRMGYRLQGQILKRTTDRELLSHGLLPGVVQVPHNGQPIVLMNDAQTTGGYPRIACIIEADMYHLAQIPLGQPIHFVQCSLEEALKARQDQQRYFEQLAWRLHNEN
The following text describes a protein:
Function:
Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSRLIFEARRRLAPPSSHQGTIIIEAPPELPRVIPPSLLRRALPYLIGILIVGMIVALVATGMRVISPQTLFFPFVLLLAATALYRGNDKKMRTEEVDAERADYLRYLSVVRDNIRAQAAEQRASALWSHPDPTALASVPGSRRQWERDPHDPDFLVLRAGRHTVPLATTLRVNDTADEIDLEPVSHSALRSLLDTQRSIGDVPTGIDLTKVSPITVLGERAQVRAVLRAWIAQAVTWHDPTVLGVALAARDLEGRDWNWLKWLPHVDIPGRLDALGPARNLSTDPDELIALLGPVLADRPAFTGQPTDALRHLLIVVDDPDYDLGASPLAVGRAGVTVVHCSASAPHREQYSDPEKPILRVAHGAIERWQTGGWQPYIDAADQFSADEAAHLARRLSRWDSNPTHAGLRSAATRGASFTTLLGIEDASRLDVPALWAPRRRDEELRVPIGVTGTGEPLMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSAERLIVIYADFKGEAGADSFRDFPQVVAVISNMAEKKSLADRFADTLRGEVARREMLLREAGRKVQGSAFNSVLEYENAIAAGHSLPPIPTLFVVADEFTLMLADHPEYAELFDYVARKGRSFRIHILFASQTLDVGKIKDIDKNTAYRIGLKVASPSVSRQIIGVEDAYHIESGKEHKGVGFLVPAPGATPIRFRSTYVDGIYEPPQTAKAVVVQSVPEPKLFTAAAVEPDPGTVIADTDEQEPADPPRKLIATIGEQLARYGPRAPQLWLPPLDETIPLSAALARAGVGPRQWRWPLGEIDRPFEMRRDPLVFDARSSAGNMVIHGGPKSGKSTALQTFILSAASLHSPHEVSFYCLDYGGGQLRALQDLAHVGSVASALEPERIRRTFGELEQLLLSRQQREVFRDRGANGSTPDDGFGEVFLVIDNLYGFGRDNTDQFNTRNPLLARVTELVNVGLAYGIHVIITTPSWLEVPLAMRDGLGLRLELRLHDARDSNVRVVGALRRPADAVPHDQPGRGLTMAAEHFLFAAPELDAQTNPVAAINARYPGMAAPPVRLLPTNLAPHAVGELYRGPDQLVIGQREEDLAPVILDLAANPLLMVFGDARSGKTTLLRHIIRTVREHSTADRVAFTVLDRRLHLVDEPLFPDNEYTANIDRIIPAMLGLANLIEARRPPAGMSAAELSRWTFAGHTHYLIIDDVDQVPDSPAMTGPYIGQRPWTPLIGLLAQAGDLGLRVIVTGRATGSAHLLMTSPLLRRFNDLQATTLMLAGNPADSGKIRGERFARLPAGRAILLTDSDSPTYVQLINPLVDAAAVSGETQQKGSQS
The following text describes a protein:
Function:
Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Has a strong preference for monounsaturated monoglycerides. Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA). Involved in fatty acid ethyl ester (FAEE) catabolism. FAEEs are non-oxidative metabolites of ethanol that are transiently incorporated into lipid droplets (LDs). Their mobilization by LD-resident FAEE hydrolases facilitates a controlled metabolism of these potentially toxic lipid metabolites.
Subcellular Localization:
Lipid droplet. Cytoplasm. Endoplasmic reticulum. Mitochondrion outer membrane. Note=Although the protein is identified in the cytoplasm, several membrane systems and lipid droplets, MGL activity is only measured in membrane fractions and lipid droplets.
Sequence:
MADLYTKDWTDVKDKPVARVVFIHGFGEHVNAYPEFFEALNERNIEVYTFDQRGFGHSRKGGPKKQGCTGGWSLVFPDLDYQILRASDTELPLFLWGHSMGGGLALRYGISGTHRHKLAGVIAQAPMLRCHPDTEPNFLLRKALTLVSKVHPNFLFDSDVQSQHITRDEAVNQRLQDDPLVSSVGSLQVFSDMLNRGTKTIELAPQFFLPLLITHGTDDNVTCSDSSKEFYENAGTKDKTYQSYPGFYHSLHIEKKPEVYEYLDKVAAWIYEHSKPSETVKSEQETAVEHPKPTATTSAPSASPTGVPVEEESHKATSDAVPPAEAKPEPVPASAAERAPTSESTTVPETIVASTTKVISEPAPRVTTAATADIVTNK
The following text describes a protein:
Function:
May participate in the energy homeostasis regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNREKVQVGDSVAPAGAGVIVVAPQDGMDDKRLAAGELPVFNCVGGRDALPAESRETSPRHEPVPAGAPPTVHRTTSFSVLDILDPNKFTSKRQTPNRTGCEFAFGAENRSDDSNHTIEHKSYQEDYDCKKTSGILKDGFVFRSDECESDFTRGNQSDSELQEDLCSEESSALTGNNDAEFGQHEDDDSISKSPDGQQTQQSSSNGQNHQVKPKRKRSGSDSKSGKPRRARTAFTYEQLVALENKFKSTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADTSAPTSGGGGGNGPSNGLGGLSPLSPSPPMSGHLSMHTSYPGHTPGGLVCTTQLPFLPGHAVLSPFMLGSQTYGAPTFYAPHL
The following text describes a protein:
Function:
Possible role in granule neuron development.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass type II membrane protein.
Sequence:
SGGAAWRARPRAGGWNRALPSPARVEPTMPRGRAALLALGALLACGLLLLPPAARRHVPARLPANATVRAGVAWVGRRPDVLLLHGQAFSSGTWQALGTLALLAAEGHRAVAIDLPGRSESAGAVARGRGRAAFLRHVVQRLGLRRPVLVSPSMSGRFALPFLLAHGRQLAGFVPIAPVGTREYGAVQYQQVQTPTLILYGDRDTGLGQQALQSLRHLPKHRVVVLPGAGHACYMDKPEDFHRALLGFLGQLQ
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Sequence:
MSLVKIDFNRKIVNPVDIIAKLEKYNTGLTCDLVLISNKICERGVYQHVTSELVAEIAASMAANHPDYISVSFYNLLFANTIISGLNLGCLGQDQANVREIWVERSLSLPPFVTYEVYNTITKHAKELEAKIVPERDDYYDYIGLKILERSYLLKINGRVVESPQHMLMRVAIGIHKDDIDSVIQTYQMMSEGWFTHASPTLFNAGTPNSQLSSCIMICMVNNSIGRTYDILKECAVVSKSAGGIGVSLHNVGSTGGTNATSSRIIPMLREEQRALDLSYALWVPDLFMERVQSNGSWSLANCWGEDFVKLYEQYEAEPRLTKEMHVLEIGPYQRNE
The following text describes a protein:
Function:
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Sequence:
MRVLKFGGTSVANAERFMRVADIIESNARQGQVATVLSAPAKITNHLVAMIDKMVAGQDISPNISDAERIFAELLRGLADTQPGFDYDRLKALVGHEFAQLKHLLHGISLLGQCPDSINASIICRGEKLSIAIMEALFQAKGYHVTVINPVEKLLAQGHYLESTVDITESTRRIGASGIPSDHIILMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTVPDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIARFQIPCLIKNTSNPQAPGTLIGGESIDEDSPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRSGISVVLITQSSSEYSISFCVPQGELLRARRALEDEFYLELKDGVLDPLDVMEHLAIISVVGDGMRTLRGISARFFSALARANINIIAIAQGSSERSISVVVNNDAVTTGVRVCHQMLFNTDQVIEVFVIGVGGVGGALIEQIYRQQPWLKQRHIDLRVCGIANSKAMLTNVHGIALDNWRQELAEVQEPFNLSRLIRLVKEYHLLNPVIVDCTSSQAVADQYADFLTDGFHVVTPNKKANTSSMNYYRQMRAAATKSCRKFLYDTNVGAGLPVIENLQNLLNAGDELMRFTGILSGSLSFIFGKLDEGMSLSEATRQAKALGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPASFDASGDVDTFLARLPSLDAEFTRLVANAAEQGKVLRYVGVIEDGRCKVRMEAVDGNDPLYKVKNGENALAFYTRYYQPIPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Sequence:
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRVFKKRQTKVKSFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDSLHTYIVQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCRYNETTVYDPAFHVTLDSSHPHFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNFPTSNQRS
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDPSQSGTPSLFPVMDIPVAYPPAAYPPCEVAVAAAAYPRLLYAPPDAAAAQQAAAAQQQQQLLGAPVVCPPAAYPPGEVAVAAAAYPPQLYAPPDAAAAQQATAAQQQLLGAPVRVAYAPPDAAAVQQAAAAQKHKHQLQMLWLELRREIEATTDFKKHNIPLSRIKKIMRADPDVCAITAEVLVVFPWACEMFILELTRHGWAHAEANKRRMLQKSDIVAAIARTDVFDFFRDTVLHDDAKEGADAAPAAAAAAEKAHPAAGAPATDPLANYPMPQQ
The following text describes a protein:
Function:
Is able to catalyze the hydrolysis of aryl-phospho-beta-D-glucosides such as 4-methylumbelliferyl-phospho-beta-D-glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Is not essential for growth on arbutin and salicin as the sole carbon source.
Sequence:
MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKIPGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLAFYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGDRVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPEGKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGWAPTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIPGVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTVQDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEESTSDLKRLKKKSFYWYQDVIKTNGESL
The following text describes a protein:
Function:
As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
Subcellular Localization:
Lysosome membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MGAEQSGDADHKHSDFSASVVPSPAKHRAKMDDIVVVAQGTQSLRNIHNDPDVIKLQEIPTFQPLLKGVLSGQTSPSTVCLEKLDSAQVLQLCVRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVEALFSIMQERQKRYAKYAEQIQKVNEMSMILRRIQMGIDQTVPLMERLNNMLPESLFWMLPMEHITFALDCLSYAWIRCFLA
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLEFLFISLLWLFKPIYFLLFTVMFSFLIFNNFSWGGLFLVLDSYSFILLIVMSLFILGIIVISEKNNNLLILSEILVFICIIFFIPSNMMMLYMFFELSMFPILVMILGYGSQIEKINSSYYLMFYAAFCSFPFLFVYFKSNFLLVFTYYNFVISWEMFFILSLSFMMKFPIYFLHLWLPKAHVEAPTTASMLLAGLLLKLGTAGFLRILGSLSFVHNNVWILIAFLGMILGSFCCVFQSDSKALAAYSSVTHMSFLLLSLVFITMSSKISSVMLMLAHGYTSTLMFYLIGEFYHTSGSRMIYFMSSFFSSSMIMGILFSVVFLSNSGVPPSLSFLSEFLVISNSMLISKSMFVMIFIYFVVSFYYSLFLITSSLMGKGYHNFNTWNVGFSAPLVLMMYNVFWLSVFY
The following text describes a protein:
Function:
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
Sequence:
MDTVEKIVEDFASDIAMSPFSSGTRLRDMIRAIRACKTAAEERAVVRRECAAIRTAISENEPQLRHRNMAKLMFIHMLGYPTHFAQMECLKLIAAAGFPEKRVGYLGLMLLLDERQEVLMLVTNSLKQDLNHPNQFIVGLALCALGNICSAEMARDLSPEVERLMRSREVNTKKKAALCSIRIVRKVPDLAENFMALAASLLKEKHHGVLISAIQLCTELCKASKDALEYLRKNCIEGLVRILRDVSNTSYAPEYDVSGIADPFLHIRALKLMRILGQGDADCSEYMNDILAQVATKSESNKNAGNAILYECVQTIMGIEATSGLRVLAINILGRFLSNRDNNIRYVALNMLMRAITVDALAVQRHRTTILECVKDADASIRKRALELVFLLVNDTNVKPLTKELIDYLNMADPDFKGDLTSKICSVVEKFSQEKLWYLDQMFKVLSLAGNHVKDDVCHALIVVLSNASELQGYSVRSFLVRVAVWCIGEYGEMLVNNVGMLDGEEPVMVTESDAVDAVEVAFNRHSADVTTGPMCLVALLKLSSRFPSTSERVRQIVGQNKENVVLELQQRSIEFSSIIQKHQSIRSSLLERMPVLDEASYLVKRATATKATISADKLAPAVTPGGLKISNGVAKPPSAHLVDLLDLSSDDAPASTTASTATPNDFLQDLLGIGGVSSSTADVTSTASTDILMDLLSIGSSPSQNGTPAVGHPGQESKPIPAAPEAIDLLGSLSSTETKPTSVVPQAMDLLDGLSSSTSVSGLEKTAHPSITAFQSPTLKITFDFKRQSGNPRETMIHATFTNLTSSTFTDFIFQAAVPKFIQLRLDPASGNTVPAKGNGSVTQGLNVTNNQQGQKPLAMRIRMSYKVNGEERLEQGQVSNFPSGL
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MYNQGGQGKPQHPIETYQGPPEHTGAGPIGFPVYQQPVAFSNQPHPGMPPPTQWIPAPPPMNCPPGLEYLTQIDQLLIHQQIELLEVLTGFETNNKYEIKNSLGQRVYFAAEENDFCTLNCCGSLRPFVIKILDYSNREVIQIERPLRCSSCYYPCCLQKMEIQSPPGVPIGYVVQKWHPFLPKFAVLNEHQEEVLKIVGPCVACSCCSNIDFDVKSLNEDAIVGKITKQWTGFVKEAFTDADNFSIQFPIDLDVKMKAVMLGACFLIDFMFFEKSGGNHSRASVWQ
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein. Peroxisome membrane.
Sequence:
MADVANKTPSTTGSEGGKDATPGAEEGKKEQAASNTPSSNQSETVRENMISTAVKFLQNPKVRQSPFPQRKAFLLKKGLTAKELQVAIDRSGTASDEHRPIQNLTNNQATISPTQPASVVAVPNTQEVVPTTAAIASRHYRWRDIAVIAALVAGAFYGIKVLITRFIMPWFKQQKDNKEHLRRIETSVGELRADVAITVGGLQSTLESVKDSVSDLQTKVDMITRGPLNQGGNVESHVVGELKKDLATIKGLMLSRQQFPSAPKLPQRNSSIPSWQKSSTEVGKLTNGSIENGIDKKIDNKFTAVNNEVNDDESTNHREDAASELHEVQSNDVEINGIASEADERYG
The following text describes a protein:
Function:
May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.
Subcellular Localization:
Secreted.
Sequence:
MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGGAEQRWLVEPQIDDPNSNLEEAINEAEAITSVNSLGSKQALNTDYLDSDYQRGQLYPFSLSSDVQVATFTLTNSAPMTQSFQERWYVNLHSLMDRALTPQCGSGEDLYILTGTVPSDYRVKDKVAVPEFVWLAACCAVPGGGWAMGFVKHTRDSDIIEDVMVKDLQKLLPFNPQLFQNNCGETEQDTEKMKKILEVVNQIQDEERMVQSQKSSSPLSSTRSKRSTLLPPEASEGSSSFLGKLMGFIATPFIKLFQLIYYLVVAILKNIVYFLWCVTKQVINGIESCLYRLGSATISYFMAIGEELVSIPWKVLKVVAKVIRALLRILCCLLKAICRVLSIPVRVLVDVATFPVYTMGAIPIVCKDIALGLGGTVSLLFDTAFGTLGGLFQVVFSVCKRIGYKVTFDNSGEL
The following text describes a protein:
Function:
This heterodimer has insecticidal and cytotoxic properties. Induces immediate paralysis when injected into blowflies (Lucilia cuprina), and then death within 24 hours. Also inhibits the growth of Aedes albopictus mosquito C6/36 cells.
Miscellaneous:
MISCELLANEOUS: Electrospray ionization experiments give a mass of 6598.6 Da for DELTA-pseudomyrmecitoxin-Pp1a heterodimer (subunits A+B).
Subcellular Localization:
Secreted.
Sequence:
KIPNILKGGLKSICKHRKYLDKACAAI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSSVQSLREFIGERLTAAAEEIFTHVEQTICKLEGELSRQRRLLDVMIMKPHVQQKPTVLPQSDLRNQDWKFSGKQEESDARQIKEQEEEICIRQDEDPLGLKQEADILMVTLLEENEFSREEDLNNQQLQTQSFNDGQDEEEAASSSTAEPRIINDRNHVRKTVRIHSCKVCRKSYTAAHSLKCHMRVHTGERPYSCKECCKSFSQSSHLTTHMITHTGAKMFSCRLCGKRFSQSHHLGSHMRTHSGEKPFSCEECGQTFSQRSHLTGHMTTHMGEKLFFCEFCSKGFSRSTHLSSHRVIHTGSRPFSCSECDKSFTQSSNLTRHMKTHSRGGALPGS