lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.
Sequence:
MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRKKSTRGDQAPGHDREAEAAVKEKEEGPEPRLTIDEAPQERLRETEGPDFPSPSVPLKASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPTWLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLRTNLAPRT
The following text describes a protein:
Function:
Component of the RavA-ViaA chaperone complex, which may act on the membrane to optimize the function of some of the respiratory chains. ViaA stimulates the ATPase activity of RavA; The RavA-ViaA system is involved in the regulation of two respiratory complexes, the fumarate reductase (Frd) electron transport complex and the NADH-quinone oxidoreductase complex (NDH-1 or Nuo complex). It modulates the activity of the Frd complex, signifying a potential regulatory function during bacterial anaerobic respiration with fumarate as the terminal electron acceptor. Interaction of RavA-ViaA with FrdA results in a decrease in Frd activity. It also interacts with the Nuo complex, known to be involved in both the aerobic and the anaerobic respiration. The RavA-ViaA system binds to specific membrane phospholipids, and might chaperone certain respiratory complexes by acting on lipid microdomains in which these complexes are inserted. The RavA-ViaA system also plays a negative role in bacterial persistence upon treatment with antibiotics through the association of the chaperone complex with Frd. It sensitizes cells to sublethal concentrations of aminoglycoside (AG) antibiotics. The system can facilitate uptake of AG across the membrane when cells are in a low energy state. It sensitizes cells to AG through a proton motive force-dependent mechanism. Under fumarate respiration conditions, it sensitizes cells to AG via a FrdA-dependent mechanism. It does not sensitize cells grown under nitrate respiration to gentamicin.
Subcellular Localization:
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the membrane via interaction with specific lipids.
Domain:
A protomer can be divided into three domains: a highly alpha helical N-terminal domain (NTV), a flexible middle domain (MD) and a C-terminal VWA domain (CTV). The MD domain interacts with the triple-helical domain of RavA and increases its ATPase activity. Interacts with free FrdA through the C-terminal VWA domain. The C-terminus region also mediates interactions with phospholipids at the inner membrane.
Sequence:
MLTLDTLNVMLAVSEEGLIEEMIIALLASPQLAVFFEKFPRLKAAITDDVPRWREALRSRLKDARVPPELTEEVMCYQQSQLLSTPQFIVQLPQILDLLHRLNSPWAEQARQLVDANSTITSALHTLFLQRWRLSLIVQATTLNQQLLEEEREQLLSEVQERMTLSGQLEPILADNNTAAGRLWDMSAGQLKRGDYQLIVKYGEFLNEQPELKRLAEQLGRSREAKSIPRNDAQMETFRTMVREPATVPEQVDGLQQSDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLHGESWREKVIERPVVHKDYDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRIALAENRRCYIMLFSTEIVRYELSGPQGIEQAIRFLSQQFRGGTDLASCFRAIMERLQSREWFDADAVVISDFIAQRLPDDVTSKVKELQRVHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLLRRWRR
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDLSQPAGENYANPKTCFFHVLFKAAALAFYILSTLFFDSFVIIFVVTVILAALDFWVAKNISGRILVGLRWWNEINEQGESVWKFECLDQQSLARMNKKDSWLFWWTLYLSAVSWFVLGIFSVIRFEPDFLLVVGVCLCLGIANIVGFTKCRKDAKKQIQTFATHTIASRFSSTIQSAFSVV
The following text describes a protein:
Function:
Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney.
Subcellular Localization:
Cleavage furrow. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Midbody, Midbody ring.
Sequence:
MSSRSPKELIKSKWGSKPSNSKSETALERFRGEIAALKTSVDEITSGKGKLTDKDRHRLLEKIRVLEAEREKNAYCLTEKDKEIQRLRDQLKAKYSTTALLEQLEEKTKEGERREQLLKSLSEETDVLKKQLSATTARLAELEGKASTLRLSQTVATSCLNPSMSEIHEMEVQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEQQKSETAAHVLPQQTKKTESEGYLQEEKQKYYNHLLVNAKKDLEVERQTVTQLNFELSEFRRKYEETQKEVQDLNQLLCLQRKADVQHLEDDRHKTEKIQRLKEENDLAREKLGEEKKRSEELLSQVQFLYTSLLKQQEEQTKVALLEQQIQACTLDFENEKLDRQNMQHQLHVILKELRKARNQITQLESLKQFREFAFTEPLVTFQGETENRGKVASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) for Ras family proteins (in vitro).
Sequence:
MAKFLAELLGCTLPEKGASPMFECRSQPHIGLRHVTKQRDKMPQTPPFPVMYGSTNGYNKNLYKAKEEDYEGLYYHDNNLISGSLEALIEHLVPTVAYYPDRTYIFTFLLSSRLFLHPYELMSKVCHLCVDQQRLSDPQADKARVRKIAPKILQLLTEWTETFPYDFRDERMMKSLKELTHRLSTGEDLYRKAVQQMTQTLIRKLTTLSQYEEALAKINSSVTDRLTVLKTKPQSIQRDILTICNDPFTLAQQLTHIELERLSYIGPEEFVQAFVQKDPLDNDKNCFSDHKKASNLEAYVEWFNRLSYLVATEICMPVKKKHRARVIEFFIDVARECFNIGNFNSLMAIITGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGATQRSITAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVTEFMTWKKVECPFDRDRKILQYLLTAPVFSEDALYLASYESEGPENNMEKDRWKSLRSSLLNRT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of receptor let-23 and let-60/Ras during vulval induction likely by down-regulating the expression of phosphatase dep-1 and lin-12/Notch in vulva precursor cell descendants with a primary cell fate. Acts to repress beta-catenin target genes. Required for asymmetric division of T-cells. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation.
Subcellular Localization:
Nucleus.
Sequence:
MTDKPGSAEDTIEMDDTCSPQFVQEVNRIKSQIKSLVEENHTRKFFRPLTSNIGDETAILRIQFNNMMSKMEEKEKQSLVKELIKMVHHVAEKNSPDRVFVGTNYERVVDQLLRYAHQKGAISTNLCAEGLIMTSDFRLCSRICQEKWKFINDCIPKIDYKGIRNILRYILESQLRRLPYSLSPEQVNEIRIVENVILHIVDRDSNLMPPLITLSEIMRGMPKQALMLPRLTEKLASLSVHFRPIADLSHVCGRGFVYPIPLHPSFYPLTSCWEEHGLNASNTIVQPHHTLPYRPEHTSTYLYTLYMILRQPLGKDSLHPPSKTKTKTNWEMLISVMICESMAEAESLPETEPIPRYQWDNIVNIVIYGITQHLLVPKTFFNVLKNLIKRCKYTRARDEVMWIVFQVVGSLSNLTRLDDAVTEIVELYNELFDGDVVWMGASDHPALFARFLAAAGTWMILEKDFADKMPPANETIKSHIKFIQDGVDNFDSSNTAMLAVLSNIYRTDTKMGKLIVPTLQQMLESIDDTKSLFELSYKRMAVNCFSAFPVEFMEALTFRSKKTLLIQCFQPLRSFSTVRLPSPAVFETVAKICESEDYEMAVKDMEHLAQRSLHVATAADRSSGEHQNVQAKDQCYFLFDFLVYRLPHLHAYSKYSSTVNALSYFTQHIPNNPQNHQIYRLMEQFLMRRWCWAGFHGCITAHTQMFGTSYKDNTMMRHMAYPKTFSVPDQYPFAINPEIFKMAIYSFLRAVKITAQDIAIEKTMFPTIINGFGWPEKSTSYFPKWALDAIKASDTSNAVNTEEILSDVRNTARMHTSLTPNQFVIRYGEDRDPATSHCMLAVLFHFAYNSVDSTYNITSEFYEVMEKKTPKEIVVMGNYLVDYIIADAKTQDCNEKTFKNIAKAAALLVFQFQVLRADRLLLSLIMHPATDEDALICIQIANEFILTPEFQERIRWYHQNVPKKDHFPTEYIKAIVKYHDAFPEFEACELVRSYDSSSNVHMPTYYGCLIERLLPIMDQYLHVALEQQGYKLNPQILQSVSMLYKFHAMPIHFMYSVLFTSHGLMSGPDAKSFVLAFATQIEECHLTEAFEKFNHQKSSREQLIMELIDRMSASLDFILTPPPFVAKDWKIAELSPGAQTLYLACIELMASPHSPETLVAAMINVMQMKPHARPFNIVNLTALLLTALPAAYSNALHDEFVAVFVNGETANLKFEEIVFDNYEESLLLNLPNRARTINVISQQYWLHCSLSLLNFFSHEYVPRILEHVKTEKDLWYTLRLVMPYLRRYYENWDTAKQMRSQRENFGPLHIVKLVFQKLGSMAEEGVEIVYEQHLCDLFYNCKYFFAGDFLRNTAITEFAKLPEKMRDRLKFYVSQSEPTAEQETPPEKEKSPEKEKEQEQEQHVKAHQPLESTPSVSSLPQMQHHLQQAPLLPSHQMMPPPQQHSSSLQHHLQHHTSTHQMMDTSQHQTIQQQSNHPTQQQLQHQIPNMSMHQQMGPQYPGAVFHHPSGPVGHVPMQYGMGHHMQQHPHLPHHQQMPAPMHTMNPMMQNMTPQQQYLYMQQLQQHQQHQQYMQQQQQHHHQHQQQPH
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MDSDEETVFKTPIKRKKSTTIIDEEDDDILIDKVDNGNNKGDDEDINFKTPSPKIKSRLKRIKSSPSSDIDFTPSPKSNQKSKNGTPKSTTSSPKIANSTSPYKPTITPPTTPSPSKKDQIKKKINKSPISATQSPSSSPLSQPKSKPIQNNNDNNSYDNEITNDIDNPWDFGTSDIRMNDDGSMSNDNQYFATPEKYSSPSKQQDQDKSPSPQKNVNKKNEKDFKISNKKVILRSIKDKDLLSFKGVSKLYNSLKLSGFSTKQSNKANLEKLFGIYSKWTKELNPYVTLENSIINVERLGRNRIVRNHIDDLKNGIVFSYNEPKDNQNDVNDNDIKNNNNSDDFDFDIDNEISNPNNSKVDFVPPHQAKKNDNTHSNSFGQFKNNNISNINNNNNNNNNNNNNNNNNINNNNNFNNNNNNFNNNNINNNINNNINIFKKVATTSILPPKDNNGGRGGGIKLSLPKKPSK
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVENSPSPLPERAIYGFVLFLSSQFGFMLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLITIVIGYVLLFGINMMSTSPLNSIHTITDNYAKNQQQKKYQEEAIPALRDIPISEVNQMFFLTAKKP
The following text describes a protein:
Function:
Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPGHPGAAEQLVKTGWRSWHLGFWKALAPLQAAWDAFSQPVPASCGQLLTQLLLCASLAAAAAGLVYHWLASLLLYPPGPSAMVATVCGLLVFLSLGLVPPVRCLFALSVPTLGMEQGRRLLLSYSTATLAIAVVPNVLANVGAAGQVLRCVTEGSLESLLNTTHQLHAASRALGPTGQAGSRGLTFEAQDNGSAFYLHMLRVTQQVLEDFSGLESLARAAALGTQRVVTGLFMLGLLVESAWYLHCYLTDLRFDNIYATQQLTQRLAQAQATHLLAPPPTWLLQAAQLRLSQEELLSCLLRLGLLALLLVATAVAVATDHVAFLLAQATVDWAQKLPTVPITLTVKYDVAYTVLGFIPFLFNQLAPESPFLSVHSSYQWELRLTSARCPLLPARRPRAAAPLAAGALQLLAGSTVLLEAYARRLRHAIAASFFTAQEARRVRHLHARLQRRHDRHQGQQLPLGDPSCVPTPRPACKPPAWIDYRLDALRTESSEGEGKELWSCRDLSCNLGPVPPPCVTLGKSLHLSEPRFLHLHNDSIFTIDVTYFPRRDVVRMEGNTGHDRPG
The following text describes a protein:
Function:
Putative transcription factor, which cooperates with EBNA2 to activate transcription.
Subcellular Localization:
Nucleus.
Sequence:
MLMKLTNCNIHTCLKQTSVLSPTLDIPQIYKPHWTGFQQTTQLLRMPAIDAGETSGENASGTWPGETQQPRRLKTLSNYSTEPWQVKWCQTALTLRSRTPVLETEESQECHLLSLSLTRSLYSAPCSKSHVPSRKTTHQHGLGLGLGLSLSLSLSLLPLRCNGMEGVLPKCGFSGARPSPEPLTHLGRLKGSAERETPAAARDGTGTPPWVWRRSNQEPSDPLRDGVRRYLQLPSDWTVLILHAKVAQKSYGNEKRFFCPPPCVYLTGPGWKEKKEEIKAKDLTESSSKVCGYIGLDSMGNSHVESQKLNFEEQPDSKEFSCAKALYISDSDKRKHFRLVLRLFFSNGQEIGTFHSKLIKVISKPSQKKQSLKNTDLCISSGSKVSLFNRLRSQTVSTRYLSVEGETFTASARQWAAFTLYLDEFCSQSKGEFLLREGYIRYGSIVRLICTVTGMALPPLIIRKVTKQSVMLDVDEPISQLHKCAFQLYGSDGMYLCLSAEKVIQFQAAPCAKEKNRELLNDSSCWTIIGTETVEYTFNDSLTGMLDPVSPVPLITNLELTGGGDVAMLDVQGEHFHANLKVWFGDVEAETMYRSPTSLVCVVPDVSAFSHDWRWLRYPITVPLLLLRNDGLIYSSTFSFTYTPEQSFITEPSILPDMIQDSDTLLDTIHQEFTKANFHLFMQS
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKKKRNPSAEEAGDGEQTAAELGDFETTLGDVETIVRKLESGALTLDDSLKQYEVAVAKMRQCYQLLDVAERKISVLAGVDAEGRPVTEPLENMSGGESLVQKQASRGKRRGAVAPDHSASDTTGVDSADLDSAEDDE
The following text describes a protein:
Function:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48.
Sequence:
MFRQSKRRIASRKNFSSYDDIVKSELDVGNTNAANQIILSSSSSEEEKKLYARLYESKLSFYDLPPQGEITLEQFEIWAIDRLKILLEIESCLSRNKSIKEIETIIKPQFQKLLPFNTESLEDRKKDYYSHFILRLCFCRSKELREKFVRAETFLFKIRFNMLTSTDQTKFVQSLDLPLLQFISNEEKAELSHQLYQTVSASLQFQLNLNEEHQRKQYFQQEKFIKLPFENVIELVGNRLVFLKDGYAYLPQFQQLNLLSNEFASKLNQELIKTYQYLPRLNEDDRLLPILNHLSSGYTIADFNQQKANQFSENVDDEINAQSVWSEEISSNYPLCIKNLMEGLKKNHHLRYYGRQQLSLFLKGIGLSADEALKFWSEAFTRNGNMTMEKFNKEYRYSFRHNYGLEGNRINYKPWDCHTILSKPRPGRGDYHGCPFRDWSHERLSAELRSMKLTQAQIISVLDSCQKGEYTIACTKVFEMTHNSASADLEIGEQTHIAHPNLYFERSRQLQKKQQKLEKEKLFNNGNH
The following text describes a protein:
Function:
Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease.
Sequence:
MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEMAYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDPKKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIVVIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLIIQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFDNTILAEMAAPPLTTVAQPIKEMGAERHRTAGRSNRGKRKAKQKIVLPPELVVRHSTSPLNT
The following text describes a protein:
Function:
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
Sequence:
MTVTDIASRTYNHSWRLDPIIRSLLDTDFYKLLMLQMIREDYSNQQVTFSVINRSRHVRLAEIIDEGELRAQLDHARTIRFTKKELIWLAGNTFYGKTHMFSADFIRWLAEFRLPEYELRKVEGQYELHFHGPWTHTTMWEIPALAILNELRSRAAIKGRGRFELDVLYARAKAKLWTKVERLRKLENLRLSDFGTRRRHGFLWQRWCVEAVKEGLGPSFIGTSNVLLAMDNDLEAIGTNAHELPMVAAGLAKDDEELRWAPYRILDQWRQTYGGNLLIALPDAFGTKAFLRDAPEWVADWTGFRPDSAPPIQAGEEIIAWWEKKGRNPRDKLLVFSDAMDVGSIEETYHHFTGRVRLSFGWGTNLTNDFVGCAPDGSFNLDPISLVCKVSSVDGHPAVKLSDNPEKATGLPSEIERYLRVFGDVGRVRKPVLV
The following text describes a protein:
Function:
It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Secreted. Synapse.
Sequence:
MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD
The following text describes a protein:
Function:
Specific binding to the autonomously replicating sequence 1 (ARS1). Interaction with regulatory regions: probably involved in compacting the mitochondrial genome. It might play a positive role in gene expression and replication.
Miscellaneous:
MISCELLANEOUS: Present with 3810 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MNSYSLLTRSFHESSKPLFNLASTLLKASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPLN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5/prx-5 receptor from peroxisomes to the cytosol, thereby promoting PEX5/prx-5 recycling (Probable). The retrotranslocation channel is composed of PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5/prx-5 through the peroxisomal membrane (By similarity). PEX10/prx-10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity). When PEX5/prx-5 recycling is compromised, PEX10/prx-10 catalyzes polyubiquitination of PEX5/prx-5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity).
Miscellaneous:
MISCELLANEOUS: Complex locus in which transcription results in the production of one large primary transcript that gives rise to two functionally distinct proteins, wars-2 and prx-10.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5/prx-5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.
Sequence:
MNTYVAEIGEIVRSQRRDEEYIEDITERLSRVSKELLGQRTWIRWFPYLKSIASTLYYTSTVVLGNQTLGEEYVHLFESNGLERTVPSIPSRISFVLLHSAFPLISNYLIQKAESTLTHPSTESFLGIPIRKNQKARQSFLDVFFWLRTKLFPQLQRAHIALFYITGAYYSIARRFTGIRFLSASAHSDIPALKVYRFLGYITLIQLAVSIGISLYSFLEQEKFNNKLKKEKKENNGGSDRNLDENSLFHPTFQCSICLENKNPSALFCGHLFCWTCIQEHAVAATSSASTSSARCPQCRLEFQPRDVTPLLNL
The following text describes a protein:
Function:
Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation. Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF. Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity).
Subcellular Localization:
Cytoplasm. Membrane; Lipid-anchor. Endoplasmic reticulum membrane; Lipid-anchor. Note=In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress.
Sequence:
MGVNQSVSFPPVTGPHLVGCGDVMEGQSLQGSFFRLFYPCQEAEETSEQPLWIPRYEYCAGLAEYLKFNKRWGGLLFNLGVGSCRLPVSWNGPFKTKDSGYPLIIFSHGMGAFRTVYSAFCMELASRGFVVAVPEHRDGSAAATCFCKQTPEENQPDNEALKEEWIPHRQIEEGEKEFYVRNYQVHQRVSECVRVLKILQEVTAGQAVLNILPGGLDLMTLKGGIDVSRVAVMGHSFGGATAILALAKEMQFRCAVALDAWMFPLEHDFYPTARGPIFFINAEKFQTVETVNLMKKICDQHHQSRIITVLGSVHRSLTDFVFVAGNWISKFFSSHTRGSLDPYEGQETVVRAMLAFLQKHLDLKEDYDQWNNFIEGIGPSLTPGAPHHLSSL
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MSHRINVLIVGASGMLGHTLFGRLFENDKLDTHATVRSVSELSRWFTDDHLLKIHGGIDADNFDSVLAVLAQIKPDVVINCVGVIKQLPAAEDPVVCIATNALFPHRLAVACKAAGARLVHISTDCVFSGEKGDYRETDRSDATDLYGRSKFLGEVTSDHCVTLRTSIIGHELKGGYGLVEWFLSRKGPVKGFTNAIYTGFPTIEIARIIEKYIICDMNLKGLYQVASEPISKYELLELIAAQYGKKIEIIPFGDFHCYRSLNSDKFRNATGYSAPAWPELIAEMHNDYVTSPWYRHKLREGSH
The following text describes a protein:
Function:
Required for incorporation of cotE into the spore coat and for the formation of the outer layer. Has a cross-bridging function between cellulose and other coat proteins.
Subcellular Localization:
Spore wall. Note=Accumulates in prespore vesicles coordinately with other coat proteins.
Domain:
The N-terminal part (1-200) directs accumulation in prespore vesicles; The C-terminal part (333-532) binds cellulose and cotE simultaneously and specifies incorporation into the coat.
Sequence:
MRLLSVLLIGFLCLAGTYAQKYQLSPAYNDPYLTDDKTGTHDFWVQNASLPVFYGFHDWNFQDNSGIMEINGDEMHITGKIYPTVNMGDCHRYNVDLVFKKDKSGNVMPKKELRESAYVPHGPIDPATWKYYTFVQGKWTGFGCDPQNVVFSGAEGGMPLQLGYGANGKNGDNGISVWLIYGYTIVDINCNIRPIITQSPTQPPTQPPTYPPTQPPTQPPTQPPTYPPTYPPTYPPTYPPTYPPTHPPTYPPTYPPTQPPTQPPVQDCSTLECPEGFHCEIVNNRRTCVCDTTVPPTHPPTQSPTYPPTQPPTQPPTYPPTYPPTYPPTQPPRASCDNVRCPRGYHCECNHWENVARCVRNEEPTHRPKPPHHGCRPDSCARGEKCICVRGKIYCIPKTTCDQVRCPRKHHCECNRKGQVFCVPDCPKLTCKQVGCPENHECVSRRGELHCVYVRPPTGRWGDDLSDLGYNQASVEAAIDAYEAQRGQRPHNNIPSNNLHQENNDNLGDGFYDGVEIGFADGGFDVNDLNGF
The following text describes a protein:
Function:
Involved in allosteric regulation of aspartate carbamoyltransferase.
Sequence:
MEQSELMVRRIKEGTVIDHIDEGKGIQVLNALRIDGSDGSLITIALNVPSGKFKKKDIIKVENKFLKDDDTNKLAVIAPKATINMIKDYKLVEKRRVSLPNEIDRIFRCSNPDCVTNSTEHIESIMDVIDKEGRVLKCRYCSRVLDVNQLKYN
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLTRYQIRNEFSLADPELYRAADKDDPEALLEGVAMSGLVGVLRQLGDLAEFAAEIFHNLHEEVMVTAARGHALMGRVKQLEAEFPSIEKAFLSQTNHSFFFTNAGVDWHPNLRTEHNLITSGDLPRCVLDSYEECRGPPRLFLLDKFDVAGAGACLKRYTDPSFFKAESDFPGIAPLEVQREKKARKVKKKGSCWRNGETPDFAQASHAKLHELFLEERIENAYNDPARLVKLKRRQLNESPLDSKSGKSYMEKFLETPPAQTKAVYEISGTPPLRLTLDNSSDSGPETLDISTVSPVKFSSQGKETSSSVSTVHEIVLKPSIEGLNGEVIDRDIMKGPEPTVNFKVRIPPSLLEVTTEEEIMVNGEGIEECNIYGDHSDDMTSEADKYIDALTTMVSERDTDNDYRPKNDIGFMDIGTYQTGSHANEEKLGVQGHSSDSQSDRISFVSDDGNSSMKKGRSSSNYSDTIDSLAKDMLSDGELAVEVFSSDRNCVAEIVEASRIQLPTCSEMQCHSSDQVLLPKETFSGEFCLPCLGEASYSSCLEDLNSTHILLDEVSSVANPLLEPQPEEVPSDIKTNSNLADNVGGKCLDDSSEVIFTDSSEKQVSLITLSTESQPIDELDRGDTTVFSDALPHLLNLLQVNPEERSGNDHLDEVPKTDFAGEICAENSVNQTIGSPTEEQHLCSTLADGERSSNSILSPECLDVMKPINSASEVSDATVEGDLKLEQITPMVDTSHICSFNEQKFSDILHDDPKLEADLMEIGASYSEQQQNVDELFDATEGEETREFICSANVVEEDAIPCDPLYDYTDTLNLKDHVDFDDLATEHVHPESIAVPAAAHGSADFGDGDPCQEGLESNEVVSQECLTELETQEETNQVVGTPSDIDSTSCKSVSYGNFNLEDDIHYSSLAQPTKDSLSFVDLTTTPASSEFSDKESEPKYLSNPMESREDMVSSHTHHQLEKQSSSEPSLDIHTYQHDVERLHIVEDSSKRMQSLDHIDQEQCLQTSFEPSKEVYSSEPLSDFSEQSGRQDEQESSQYDLVHPAFGLQPEATKAIMEEMPPLPPLPPMQWRIGRVQHVSTVPQRELVEHGQRSFPMMPQSGTGEETQIDLPTLEQGFEQSRNPLLPLVDGEERSGNVSDQLAADFMQPSPFSMHLATMDSNGNSQYGGICSDRAHSNPFLTLPTTSNENLEYGSLAIEGERVESSFSLPMPPTDATCGHIPVSLNEKEANCPSQFVLDTSSEGRPSQDPKQNFDQEHGNPHDVSVPIPTKKEEQVPTKVAEDLPTKVEEQFPTKVDEHLQHGLEASEGEKVRISNAIVQHGLAATDGETSQLTNTTLEHDLPTSEGEAACPSNTLGLIQVSEEGNSNGNPPVKLPRPRNPLIDAVAAHDKSKMKKATERIRPPTIPKVDERDSLLEQIRTKSFNLKPAAMTRPSVQGPKTNIRVAAILEKANAIRQALAGSSDDDDDEDGWSDS
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MPKKILCVAEKPSVAREAAKILSNGHMETKKGKSKFNNNFVFQRDFQGEDVKVVFTSVAGHVLNYCFPPECKNWQTFGNTKLFDCQLNTCITANMEKVVGNLQTQAKKAFLVFLWLDNDREGEGISEEVEEICKQVNENANYKRARFSGLSPREIIHAFNNPTPINRNDAAAVKLRQEIDLRIGSAFTRFQSQFKGMLQNAELISFGPCQFPTLGFVVEAFFNHIKHVPESFWKIEPLITKDNIKVTLKWDRKRLFCKLSAFAIYVDILDNPMAKVLTVDERESLSNKPLPLSTIELQRRCSKYLKISAQRSMEAAEKLYQNGCISYPRTETDSFSADFKFKDIVNALTRFKGEIGQYSNKILQQIVPPRAGKHSDNAHPPIYPIKVPDKFDTPDQQKVFEFVCRHFLACCSKDGVSLATRVTFDINGEQFHLKGTRVLEENWHEIYPYIPFKGTKIPEFKVDELISPTNIELNEGKTTAPPLLTEPDLLKKMNQEGIGTDATYQDHIAKIMERKYIVQENNYFKPTPLGLALNDGYEGMGFDFMKPRLRAEMEQGLQDISSGRQTYDAVRNNFIKQYRDAYVTAERMYDVLTREFTRQKNNPYNAPLPVEEQASKRSKSKSDGKTKKKKSSSSKSTKSSKTSKSSKSSKSSKTATTSTRKP
The following text describes a protein:
Function:
May play a role in preadipocyte differentiation and adipogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSPEIASLSWGQMKVKGSNTTYKDCKVWPGGSRTWDWRETGTESLTPLPRLECSGAISAHCNLHLPGSCHSPASASRVAGTTGACHHTRLIFFHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKVPSSTVEYLKKHGIDVQVLQTEQAVKEYNALVAQGVRVGGVFHSTC