lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAAITPSWALETTADGEVKEKTSGPGGQWRALNVGPDLIRSLLIRKFKTPTPIQRAAIPPALSTPPRDILGMARTGSGKTLAYLIPLLQRTGSTHHGQGPRALILCPSRELAVQIYTVGKDLARGMNKGKGKGKNKNEDEEDEEGKGKEGLRWALIIGGEGMDAQFEKMSSNPDIVIATPGRFLHLIVEMHMDLRHLQTVIYDEADRLFEMGFDVQLQEILHRLPSTRQNLLFSATLPSSVAEFAKAGLVNPLLVRLDAEQKISPDLALKFFSVKPGEKEASLLVLLREVIGKPNQPEPADPSSAPQAIVFVATKHHVDYVAELLRTTGYRTSLIYSSLDQVARQQQLAGFRSHQSDVLVVTDVAARGLDIPIMDHVINYDFPAGPRIFVHRVGRTARAGRKGTAYSLIVKEDFPYLCDLHTFLGTERMGEPADVLRSLPIEQLSENVEYVFHNLDETAPHITALRNVMRKGQGMFERSRTKANPTSYRQAKSLASALSNNPPRIDDMFEDAMEVEVNEEKARLLAKVAAFTPSETVFEVGKRESESAIIMKKRRKTVDERQKRVSKAEAEKSTASGMEKAPVKELPAPQLPSKNFKDPSFYLDHTQRGAEAEKGYSLKSGVESLSGAITDMTADEGTGPKAQKASQLSWDRKKHKFIKKNGSADGEKMIKSESGALLPASYSSGKYQEWKSKRRHMPDGPVEALALGGGRRGRHGPPGQKRKAEDGDGGEDAGGKGRKDQGKSKGTGKGKDDFKQKSPGKPGKKGIKQSSGLKSAMDIRKQREIAQKRKEKNARKPQKFRK
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Sequence:
MAQPSLLLLAAAVVLSLSLCDAHNKLAKKSDDVVNGPLLTSKLNAKRTLIVGPNDEFKTIQSAIDAVPDGNSEWVVVHLRAGVYAEKVVIPETKPFIFVRGNGKGRTSISYESASPHNTESATFAVHADNVIVFGISFRNAARAGLPNNPEIRTVATMVSGDKVAFYHCAFYSPHHTLFDSTGRHYYESCYIQGNIDFIFGGGQSIFQCAEIFVKPDRRTPILGSITAQDRKEESGSSGFVFLKGKVYGVGEVYLGRANEAYSRVVFADTYLSKTVNPAGWTNYNFSGSTEHVMLGEFNCTGPGADVSQRVPWSRRLDQAEAAKFLTVDFINGKDWLPAFYY
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTLSMDISVSFLKCELASTIDQAVRCAVETVLRETARVVGVKLAAARNAAAESHRENQSLRERLEISESELKAVRYYMTAAEKNIKQCLLLNRNQPGANSARSSAEDAVFVFPSRLADESPTAPAQSRDSSRKTFRSSPGRIHNLKNVPSVGLCLPTVQSVWPRDCVNRRKARGSSVGNSSALSSDSTSTQVLLDNTAALFKPQEDTEGPFYITNEGGKDHSSAVPDTERAHEDPESPGPSTNPAEDPSDMSKFEFEMSTPAGNVNELELIQVMEDADVKQGTIKIEDDPDSLTLEPPSSNLALASSANSIQEIPQISSPPVPESDGDALLALAPTAGSDSGFSRTVESPDKVHRCNICGRGFRRFYCLKTHQRIHTGERPYPCRYCEKRFRHLDSLHKHQRIHTGERPYRCAECGCCFRELGQLKKHRLKHSPTFVPVANPTFPLLPAGPSYVWPHLNTQSLDSV
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. The DASH complex mediates bipolar kinetochore-microtubule attachments and facilitates the formation of additional interactions between outer kinetochore components and spindle microtubules. During chromosome movement along the microtubule, it is required both for the sliding of kinetochores along the lateral side of the microtubule and also for microtubule end-on pulling on the kinetochore. Modulates cytoplasmic microtubule dynamics by tracking the plus-end of shortening microtubules and slowing their depolymerization. As a constitutive component of the kinetochore, mediates interaction between the DASH and sim4 complexes leading to loading of DASH onto the kinetochore.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Note=Associates with the mitotic spindle and the kinetochore. Unlike the other DASH complex members, dad1 remains associated with the kinetochore throughout the cell cycle. In the cytoskeleton, localizes to cortical microtubules (Probable).
Sequence:
MSSENMDITENIQNEQNKDFDDIDFERRRRLLTLQISKSMNEVVNLMSALNKNLESINGVGKEFENVASLWKEFQNSVLQKKDREMLDAP
The following text describes a protein:
Function:
Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor. Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. Aassociates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
Subcellular Localization:
Cell membrane.
Sequence:
MGRIEWAMWANEQALAAGLILLAGGIVGVAGQFRGWEFASYAIAAGVFVCLLEYPRSKRAKGTSVERTGQYCFTVCVKAFGPVTRNYYVRAFLHAALCVPGGFMLATVLGCVCLGIASLIYLAAAVRGEHWEPILPRKDTRKPVAESIKSPPQNPPPRPPPEIRRKQAKDVEGAAYDNPMSVTDDE
The following text describes a protein:
Function:
Component of the mitochondrial large ribosomal subunit (mt-LSU). Within the mitochondrial ribosomes, required to direct the nascent polypeptide toward the tunnel exit and position the exit at a distance from the membrane surface.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAPIPRGLSSLSRTLGWWSRQPILVTRSTAVVPVKSKSRFRPPTREPNYKTEKEFLEYARKAGLVIPQERLERPIHLACTAGIFDPYVPPEGDARMSSLSKEGLTQRTERLRKNVASQLAIRKIKEFDANFKTKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTEHCFPDMVWELKYKTVRWSFVESLEPAQVVHVRSSGLVNQSNMYGQVTVRLHTRQTLAIYDRFGRLMYGQEDVPKDVLEYVVFERHLMNPYGSWRMHAKIVPPWAPPKQPILKTLMIPGPQLKPWEEYEETQGEAHKPQLT
The following text describes a protein:
Function:
Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQSFIRRFLQWTELLDPTNVFISVESIENSRQLLCTNEDVSSPASADQRIQEAWKRSLATVHPDSSNLIPKLFRPAAFLPFMAPTVFLSMTPLKGIKSVILPQVFLCAYMAAFNSINGNRSYTCKPLERSLLMAGAVASSTFLGVIPQFVQMKYGLTGPWIKRLLPVIFLVQASGMNVYMSRSLESIKGIAVMDKEGNVLGHSRIAGTKAVRETLASRIVLFGTSALIPEVFTYFFKRTQYFRKNPGSLWILKLSCTVLAMGLMVPFSFSIFPQIGQIQYCSLEEKIQSPTEETEIFYHRGV
The following text describes a protein:
Function:
Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MKMFTCSSAKLLALFSTEMAHTCAFRRYVHDGRLRVSNMFQPMATRQSNVAGKGKELTCKSQRLMLQTGLIRQAHPGAYHLMGPALRAVEKLVRLVDQEMAAIGGQKVEMPTLTPGELWKATDRWDTMGTELFKLQDRHKADYCLGPTHEEAVTEIVAAQSNLSYKQLPIKLYQITRKFRDERRPRFGLLRGREFLMKDLYTFDTSEETARETYEGVSQAYSRVFNRLGLNYVRVEADPGDIGGSLSHEYHLPAEVGEDQLLVCSQCSFGANKEAIAENQTSCPSCSSPLTVTQGIEVGHTFYLGTKYSSVFNAAFLNNKGQPQLCEMGCYGLGMTRILAAAVEVLSLADQIRWPEVIAPYHVYIIPPKKGSKEEAASQLAEDLYDIIPQQLPHLRGEVLLDDRSHMTIGKRLKDANVLGYPYVVVVGKQALEADQKFEVIHQTEEQTQTHHVSREELLHLLSNCTTV
The following text describes a protein:
Function:
A flexible structure which links the flagellar filament to the drive apparatus in the basal body.
Subcellular Localization:
Bacterial flagellum basal body.
Sequence:
MSLTGALSSAISALSAQSQSLSMISDNIANSDTTGYKTTSAMFDALVTASSNATSYASGGVTVSGRANITQQGLLAATSNATDVAIQGSGFFAVSNSTSGGTISYTRNGAFTINNAGYLENNGNYLEGWRTDADGNVVGNESASNLTAINTQVASTSGSATTKTTVAANLPSDAATGDTYTSSMTVYDSLGAANSMQVTWTKTGTNTWSASFANPTSTSDTTTATGTASGTIAITFNSDGSLASTSPSPATVVVTGWTDGAADSSITLNLGTVGKTDGLTQYASGETTPSVNVTSIDSDGLSYGKLSSVSIGKDGVVDATYSNGQTIAIYKIAVATFADPNGLSARSDGIYSATVTSGNAALQASGENGAGTIYGSELESSTTDTSSQFSSMISAQQAYSAASQVISTVNKMYDTLISAMR
The following text describes a protein:
Function:
Probably plays a role in host phagosome maturation arrest.
Sequence:
MSMDELDPHVARALTLAARFQSALDGTLNQMNNGSFRATDEAETVEVTINGHQWLTGLRIEDGLLKKLGAEAVAQRVNEALHNAQAAASAYNDAAGEQLTAALSAMSRAMNEGMA
The following text describes a protein:
Function:
Involved in protein synthesis.
Miscellaneous:
MISCELLANEOUS: Present with 3100 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSRQGGKMKPLKQKKKQQQDLDPEDIAFKEKQKADAAAKKALMANMKSGKPLVGGGIKKSGKK
The following text describes a protein:
Function:
Has D-tyrosyl-tRNA deacylase activity in vitro.
Sequence:
MFLVDSHCHLDGLDYESLHKDVDDVLAKAAARDVKFCLAVATTLPGYLHMRDLVGERDNVVFSCGVHPLNQNDPYDVEDLRRLAAEEGVVALGETGLDYYYTPETKVRQQESFIHHIQIGRELNKPVIVHTRDARADTLAILREEKVTDCGGVLHCFTEDRETAGKLLDLGFYISFSGIVTFRNAEQLRDAARYVPLDRLLVETDSPYLAPVPHRGKENQPAMVRDVAEYMAVLKGVAVEELAQVTTDNFARLFHIDASRLQSIR
The following text describes a protein:
Function:
Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.
Subcellular Localization:
Mitochondrion.
Sequence:
MPRLPPLPPTPKFSKYFPARLLSLSPNPVLIRKAPGRILLANPSLGDDFVRALGIREGEIIVEGYAGMGGLTRSLVTGGDAVREGKEWEEEKRLESIRPGEKGKGTELPAWMEDLPAMSGYKSRSPAPRIPKLVVSTEGSVELIQRGLDYNENPHKASLDDYRGQHSDSRISNYIAKETPIIASPHKDNLLLSHSTVYVWQAIPSILEHPTVNAALPVYDPSAAPESQKKRPWSAPPPPITLVAQVPNSSLGEQLVSQWIGSAAGEEHKRSWIWEYGRVRIALLCGKSLYDRLTARPGDKINCKLSIFASAFFHITPLPPYHHVNNIDKHSKQVAESGKAPKPPKVKKSTVPAKGMPEPEPLPEDILLPPLGAKTKTVHSDFYPGSYASGGSLDRPLLLGVLLTPRLRSPILAAQKDTWDYAIRRLFVRDTMTLEDSINNLAVGAESLLPAIEAEEGRGVPVNRKRVIRYLDVEEWARVVDVFDNWAFRPDNLILDTMMGEDAIRSIGND
The following text describes a protein:
Function:
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Subcellular Localization:
Cell membrane. Synapse.
Sequence:
MSKENQNYSSFSPEKSDSLPLEESHRELERLKRDLENEKLKTQDAHKKCSMELRRYKEASEKEKNKLANDLKSKWEQQNARELQQLKDSIMREREIEIKQLLRSKKEELKEMHALLQKERDVAVRQARELQKQLTEELLNKGYARKASNTKKKEANFESVECRCKLQDVLSKLRWECDGEQAASIRHLKMELQLERNFFSKYILENFRINISALPQVKTKPFESGERKYGRYSLGSHSLRPQHQDLLPSKLQSPDNTAPVVSGIKYLEWASPETDSTCSSFKRESKDGDLSIPSRLVSCRDDSPSNKQFASEDEVILWTFPYNYSKQSFENTDEQDPSASSCTSGIEANDLRQLVNVLNHSQPNSATQKSINTLQERQNERDGSQLKQEDLLSELKVLEQRCNTLKEENISLRKNCFPETEEKVKRLKRKNAELAVIAKRLEERAQKLQEANLKMVNTPMHLKGPSLEICKKAFARQRAKDMAEQACVLLAKDKQIALLKHECLELQAKLSLGKECSSLFKLSDFDRLLRESQKEVLRLQRQIAIKYLKESLHVSKSDSQSYSSDSALVDPCFQSDKVKESPDKTKVASSGDGIKELELKKKRKECEILEQEVKKKQKRCEDLETKLHEVQTENARLVEENSQLSSKVKWAGKVETENADLKGHLAEVTGQRDSALKESHQLQSKLDNLEQVLKHMRDVAERRQQLEKDHEDALFALQKRQEEVKRLNEAQVEAKKEHEEATKLLEHTLDSLQAKVKNLEEKCRSQTEQFSLLSQELERFRLQTGDIGLLTSTLVTTDLPPPQCCSTPGVPQVKQDFTDEFLSWEIISLVDFSVGSNFSFVYVQSSLEDNIEPVNEEKIKTGECDKERPIPQPLDSSCENRKAEAHNHAVAKEKQKLEAPQSSSKSESVHESPKSCPTPEVDTASEMEDLDADSISLHPEPESRFPAKLHVYLARYSYNPFDGPNENPEAELPLTAGEYIYIYGDMDDDGFYEGELMDGRRGLVPSNFVERVSDDDLIAFQPTEINELSQSSGQDISFLSGSSNERSEDGSSLSPLPCETQATSEGASDILAVPYPRKLAIIKQLARSIVVGWEPPLVTAGTRNIQSYNIYIDNELRQNVQCGGQTKALIEKLELKTRTYRISVQSVTEDGCSDRMRCTLLVGHGYSLAPTQLRVRSLSATCAEITWQPCNSNYSHALYMNDERCGLAKAGTYWYSFSSLRPSTLYNVKVEAHPQRIPWELPLERREQKATVIQLTTPSAGPPDAPLDVQVELGPTPGVLLISWLPVTIDAAGSSNGVRVTGYAVYADGQKVLEVTSPTAGSVLVGMSHLQLLQVSKEISIRTMSPSGESVDSVPAKIPSALLNNPDCSSLINPFSNSLTSEPAMEKSLDACFEKFPSKPLSSSSPYSPPATLDACTKAKFSIHTSCSRGKSTDSLPVRISPLLLLSPLSTSSGYCQGSSRSDCLEPVVSQDGTHENAPPALPQTASIAVSGSVQPLDSASDSVEVSKISLQEKESTFIQESVELSNTKYSDMKAVTSSQPSSLEIGKTWNDSLTERSTASKEDCSSPETEHLEEENKRRCNREISIEDFLEEGPEKTANNYTNEGLEEEASLPEPIVSNLEHSPSSTLSDIMEEEEGENPEEEDSPKINKKRQIGAKARCENLSKLDCCETDSDEEILERMLALPLQKHCSKKLFSIPEVTEEEDEEEVYYKAPLAKTTMHSNDLTSEHCGKGSLLNNKSSCVLEDCALENSALLSQDWDLKPNVLISQHQHENTKTPLFGSSTCNPKRSYCWTDRANSCPESNRKRQGDAREQCSRMVANSSQTVFFNPRSHNQKEQGLHTAAKNTPQVNQKNGKSNPQKCFQSPQYSDYSDVNIKRASSYGSPGGLEIDIEYDTEDEEDLSSLKCSNHSRPNIWEDSSQTERDGWSDCSSQSEPIRHTKKRRALKKQVNVQDNSAEITLGHNIQGSRQGSRNDDLSSRLGSNTIVHTSGRDGAGKDGWNGNTPSSLPDYQEAPSPGKATGTSQLTSGSESEAAYYISPEYHQEVIPHKEQSPLKPQKLETARIFVALFDYDPVIMSPNPDAYEEEVPFKEGQILQIFGDKDADGFYHGECAGKTGYIPCNMVSELHIQNEDMGAELLKRGWVTSPTILNDLVDIVPVPDVTDVPEKSRKIQHDLSVPKKMVAIFDYNPRENSPNMDVEAELNFTAGDLITVFGPMDEDGFYYGELNGLRGLVPSNFLESAQPQVEESDAQMALHARDNTELRVAAPVDPPDSPTEDPISCGQAANSKLMSERQHPYQGFASNKKKKSLFSKGRKLFKKLGSSGKSL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MEIRILKSESNYLELEIEGEDHTLGNLIAGTLRRISGVSFASYYQPHPLSDKIIVKILTDGSITPKDALLKAIENIRGMTSHYIDEIKGLTK
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MDIDDILKEFEESSKDEKISSKTSSINLYQDLLRAMINERMAPELLPYKQDLMSTVLTMMSNQQQYLLESHEYGDMNGDSGVLSGDFKLQLMIIETDLERLNYIVRLYIRTRLSKLNKFTIFYINESSQNDNLLSKEERDYIHKYFQILTQLYNNCFLKKLPQMLTYLDDTSGGQSMIVEPDLDQPVFIKCTSEVPILLDYDGATEIDLELIKKGVYVVKYSLVKRYIDIGDVVLI
The following text describes a protein:
Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.
Subcellular Localization:
Nucleus.
Sequence:
MNPTCIAATLLDRSIPFIRQQFVFVALNLMIWDIFFMIRRQKLTLFTDCKETNTVLDLKKIIDGVTKVNPEDQRLFKGDEILDDSKLLSDCGFSTSTARAQEPAFLGLAFRGEDGEFEPLNIAPLTQPPDLPEVMKQRGEPSSDGNSDQTEK
The following text describes a protein:
Function:
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Miscellaneous:
MISCELLANEOUS: NF-L is the most abundant of the three neurofilament proteins and, like the other nonepithelial intermediate filament proteins, it can form homomeric 10-nm filaments.
Subcellular Localization:
Cell projection, axon. Cytoplasm, cytoskeleton.
Domain:
The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions.
Sequence:
MSSFYSEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAQLLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEIAFLKKVHEEEIAELQAQIQYAQISVEMDVSSKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSLTTGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEGKEKEEAEAEAEAEEEGAQEEEEAAEKEESEEAKEEEGGEGEQGEETKEAEEEEKKDEGAGEEQATKKKD
The following text describes a protein:
Function:
Probable UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides.
Subcellular Localization:
Golgi apparatus.
Sequence:
MAGTVTVPGSSKPSTPLLKDELDIVIPTIRNLDFLEMWRPFFQPYHLIIVQDGDPTKTIKVPEGFDYELYNRNDINRILGPKASCISFKDSACRCFGYMVSKKKYIYTIDDDCFVAKDPSGKDINALEQHIKNLLSPSTPFFFNTLYDPYREGADFVRGYPFSLREGAHTAVSHGLWLNIPDYDAPTQLVKPKERNERYVDAVMTIPKGTLFPMCGMNLAFDRDLIGPAMYFGLMGDGQPIGRYDDMWAGWCVKVICDHLSLGVKTGLPYIWHSKASNPFVNLKKEYKGIFWQEDIIPFFQNVTIPKDCDTVQKCYIYLSGQVKEKLGKIDPYFAKLGDAMVTWIEAWDELNPAGPAAGKDKAK
The following text describes a protein:
Function:
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MILLTVLFLCIISTYSASVKGHTTGLSLNNDRLYKLKYSTEVYVDQVKGQLHESVGYRISSDVDVNLLWRNPDGDDNQLIKITMKNVNVEHANEHKGGQNIFKGKNSQKIFGRDNLASLEKPVLLHLMHGKVMDYYSYPNEPVAMENLKRGVASLFQMQLTSGSANEVDISGNCEVVYQAQQNKVTKIKALNTCKIPRSGFTTHNQVLGISSKSTSTTTYLIEDSFVTAVMAEEIYAFGLNYLRTLTGKIVSKQRLELKSTEVGPGLIPGKQVAAVVKKVDAQYSSSPLVGQLAHTDCKNCPSLPEFWKTVRKQMQPENLSKAEAARAFLTFILRLRDAKKDEILQILKSENKDVLPQLVDAVTSAQTPDSLEAILDFLDFQSDSNVLLQERFLYACGFATHPNEDLLKTLIAKFQSPIKSNDIRETVVIIMGALVRKLCQKEGCKLPAVVEAKKLILAGLEKPESKKDVKMYLLALKNALLPEGIPLLLKYAESGEGPDSNLAITTLQRYDVSFITNEVKKTMNRIYHQNRKVHEKTVRTSAASVILHNKPSYMDVKNLLLSIGELPKEMNKYMLSTIRDILHFEMPASKMVRRVLKDMMTHNYGRFSGSGSSSAFTGYVARDPHAASIYSLDILYSGSGILRRSNLNLFQFIGKSRLHASQVVIEAQGLEGLIAATPDEGEENLDSFAGMSAILFDVQLHPVTFFSGYSDLMSKMLSASGDPISVVKGLILLTDYSQVLQLQSGLKSNVEFQGGLAIDISGTMEFSLWYRESKTRVKSRVAMVVAGDITVDSSFVKAGLETSVESETGLEFISTVQFSQYPFLVCMQMDKDQAPIRRQVTSYERLATGRGFVSRKRKEKLWAGSEFPLHQENSDMCKAVFGTQPESTSSSWF
The following text describes a protein:
Function:
Plays many key roles by phosphorylating several proteins including the viral DNA processivity factor BMRF1, EBNA1 or EBNA2. Modifies the host nuclear envelope structure and induces the redistribution of nuclear envelope-associated proteins by phosphorylating host nucleoporins. Subsequently, promotes the nuclear transport of EBV lytic proteins. Required for efficient lytic DNA replication and release of nucleocapsids from the nucleus. Contributes to the compaction of host cell chromatin in cells undergoing lytic replication, presumably by phosphorylating the host condensin complex and host TOP2A. Induces disassembly of the nuclear lamina by phosphorylating with host LMNA. Phosphorylates substrates involved in capsid assembly and DNA packaging. Facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function. Phosphorylates the viral immediate-early protein BZLF1 and inhibits its sumoylation by interacting with host SUMO1 and SUMO2. Phosphorylates also host SAMHD1 and thereby counteracts its antiviral effect by reducing its dNTP hydrolase activity.
Subcellular Localization:
Virion tegument. Host nucleus. Note=the protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.
Sequence:
MDVNMAAELSPTNSSSSGELSVSPEPPRETQAFLGKVTVIDYFTFQHKHLKVTNIDDMTETLYVKLPENMTRCDHLPITCEYLLGRGSYGAVYAHADNATVKLYDSVTELYHELMVCDMIQIGKATAEDGQDKALVDYLSACTSCHALFMPQFRCSLQDYGHWHDGSIEPLVRGFQGLKDAVYFLNRHCGLFHSDISPSNILVDFTDTMWGMGRLVLTDYGTASLHDRNKMLDVRLKSSKGRQLYRLYCQREPFSIAKDTYKPLCLLSKCYILRGAGHIPDPSACGPVGAQTALRLDLQSLGYSLLYGIMHLADSTHKIPYPNPDMGFDRSDPLYFLQFAAPKVVLLEVLSQMWNLNLDMGLTSCGESPCVDVTAEHMSQFLQWCRSLKKRFKESYFFNCRPRFEHPHLPGLVAELLADDFFGPDGRRG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes.
Sequence:
MTYFSPVENSTSKLHINIQFFLNCHLGKPLLNQEPLSGLFCQLNMDSDEGYNYEFDDEEECSEDSGADEHEDELDLGEVELVEAGLSGSERAGLCGDGGGSALGPGPGEEDEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFSECHVINPSKKSRTRQMNTRSSAQDMSCQICYLNYPNAYFTGLECGHKFCMQCWGEYLTTKIIEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPIKCKWLRKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRSTLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLLHVHEGYEKDLWEYIED
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MARPIDVSQLIAGINKKKGLDENTSGKISKPRFLNKQERSKQERLKENEESLTPTQSDSAKVEIKKVNSRDDSFFNETNDKKRNPSKQNGSKFHFSWNESEDTLSGYDPIVSTRAIDLLWKGKTPKNAAESSYMGKHWTEKSLHEMNERDWRILKEDYAIVTKGGTVENPLRNWEELNIIPRDLLRVIIQELRFPSPTPIQRITIPNVCNMKQYRDFLGVASTGSGKTLAFVIPILIKMSRSPPRPPSLKIIDGPKALILAPTRELVQQIQKETQKVTKIWSKESNYDCKVISIVGGHSLEEISFSLSEGCDILVATPGRLIDSLENHLLVMKQVETLVLDEADKMIDLGFEDQVTNILTKVDINADSAVNRQTLMFTATMTPVIEKIAAGYMQKPVYATIGVETGSEPLIQQVVEYADNDEDKFKKLKPIVAKYDPPIIIFINYKQTADWLAEKFQKETNMKVTILHGSKSQEQREHSLQLFRTNKVQIMIATNVAARGLDIPNVSLVVNFQISKKMDDYIHRIGRTGRAANEGTAVSFVSAAEDESLIRELYKYVRKHDPLNSNIFSEAVKNKYNVGKQLSNEIIY
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSQEQLIQFATQFVNVFYNAFDTNKANLANFFQQMSTLTFETSTVQGQQAVLEKIQSLPFSSTKHVVSVIDAQQIPSNGVTMVLIKVIGKLSIDNENPHLFTETFVLAQNNGNWFVLNDIMRLADI
The following text describes a protein:
Function:
Involved in the biosynthesis of phenolic monoterpenes natural products thymol and carvacrol which have a broad range of biological activities acting as antimicrobial compounds, insecticides, antioxidants and pharmaceutical agents. Monoterpene synthase which catalyzes the conversion of geranyl diphosphate (GPP) to gamma-terpinene.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MATLSMQVSILSKQVKNLNSFGMRASKLPMVARRVDVSTTRLRPICSASLQVEEETRRSGNYQASIWDNDFIQSFNTNKYRDEKHLNRKEELIAQVKVLLNTKMEAVKQLELIDDLRNLGLTYYFQDEFKKILTCIYNDHKCFKNEQVGDLYFTSLGFRLLRLHGFDVSEDVFSFFKNEDGSDFKASLGENTKDVLQLYEASFLVRVGEVTLEQARVFSTKILEKKVDEGINDEKLLAWIQHSLALPLHWRIQRLEARWFLDAYAARKDMNPLIFELGKIDFHIIQETQLEEVQEVSRWWTNSNLAEKLPFVRDRIVECYFWALGLFEPHEYGYQRKMAAIIITFVTIIDDVYDVYGTLDELQLFTDAIRKWDFESISTLPYYMQVCYLALYTYASELAYDILKDQGFNSISYLQRSWLSLVEGFFQEAKWYYAGYTPTLAEYLENAKVSISSPTIISQVYFTLPNSTERTVVENVYGYHNILYLSGMILRLADDLGTTQFELKRGDVQKAIQCYMKDNNATEKEGQEHVKYLLLEAWKEMNTAMADPDCPLSEDLVDAAANLGRASQFIYLEGDGHGVQHSEIHNQMGGLIFEPYV