lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Sequence:
MGQLLSWIRGPRDAPALQDASVEEQSQPSQATPKPTPQVSAGKPAQFEKASSGSAMAAKPGMVATATGDATGSGPAAGKQTAKAKPETASQVKGKATVPSPTAGSAAVSGTTAAASSTKPKESPKDSAKVQVEVSSAAPVAKQAPAADPFDALASSLPTSDPVTPSQPSFTGPEVKEHDITPEKGQRCGDRESTLPPGYRSENVTPPTANIQQQPKDVPKPLSTDDALESLSAGFTTSTAPPAAQKQEKNVTPAKASPVAVSPSPPADKKPKMEKVSDNFSLKTAEASPPVVKAAPPAVSVSQVPPPEKKNKVEKVPTKAGPPPAASTGGSPPLDALSALSDTLPVDKPKPESPKLRPEDFVSEKITAEKGVRVGEREDTLPPGYRFNKEDLKKLPAPEPEPSMESGDALDILSGDFMTSSAAPTVQAPVVSSSAAPVQKAPAPPAGKKDATKTSSGDFSLEEGLSASTAKKVKSHAPPPVAVCPIPPDAKKAAGGKAKPDKDDSDAFSALSDTLPAADKPKPEPPKLKPKDVVEEDIKATEGVTTGGNKCPLPPGYRFDKEDLKDIPAPEPEPSLDPGEALDFLSGDFTSSSVAPSVQAPVAPKDLPAQKKKESSAVDLLSADVVASSKASAVQASAPAPNKQKPEKTVCPMEQHITPDVLPALPQQTKPKEKKDDSDAFSALSDTLPAADKPKPEPPKLKPKDVVKEDIKATEGVTTGGNKCPLPPGYRFDKEDLKDIPAPEPEPSLDPGEALDFLSGDFTSSSVAPSVQAPVAPKDLPAQKKKESSAVDLLSADVVASSKASAVQASAPAPNKQKPEKTVCPMEQHITLDVLPALPQETKPKEKKDDSDAFSALSDTLPAADKPKPEPPKLKPKDVVTEEKVIKEKGVIVGDRDDTLPPEYRRNKEEPKEKPALKQDNSVDDKTVEDFLSADFSAPAQPPAPLPSTTTKLEPPELHSEPLKPMAGGTLDSLAGTLLPEGLQAKTKTEQLKSKNKSKTKSKSKSKTQAEAEAFAADLLSAQLTSDVVATKKEGKS
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
DEDDTSLLVIVLDCNIYSWGTSSPPLINTSKNNYIGFSKFLEHVMVFINAYLMLNQENQIALISSKIGQSSFIFPETVEQLEQEETQTENNIQNITLQSQILKRLQKINIEVNNDQQDIINSSFSAALSMALCYINRIRKESPNLKPRILVFNISPDVSSQYISVMNCIFSAQKQSIPVDSCILSQTDSTFLQQASHLTNGIYLKPHKQELLSQYLLTTFLLDTQSRKSLAYPNLKSVDYRASCFCHKKIVDIGFVCSVCLSIFCNHFSSCSTCGTKFSLKI
The following text describes a protein:
Function:
Involved in reducing some disulfide bonds in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase.
Sequence:
MKLYIYDHCPYCLKARMIFGLKNIPVELHVLLNDDAETPTRMVGQKQVPILQKDDSRYMPESMDIVHYVDKLDGKPLLTGKRSPAIEEWLRKVNGYANKLLLPRFAKSAFDEFSTPAARKYFVDKKEASAGNFADLLAHSDGLIKNISDDLRALDKLIVKPNAVNGELSEDDIQLFPLLRNLTLVAGINWPSRVADYRDNMAKQTQINLLSSMAI
The following text describes a protein:
Function:
Directly regulated by DOF3.6/OBP3; unknown function.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MALCGVCSTPNLPNLQVFRSVRNSSIGYKRNHSLWQLRSSSFRAKSVIFHCSSSLRQSPSNVEEIDDNPSVSLEDESAHVMQFKWSDFRILDRVSIGHGGRADELVFEAIVQVPDSPLFNQGVVLRKLNTTRAQRRGRRAIEVFKKLVRRRLLYHSYSMQVHGYITNNLSDDQYSFTLVHGCHGSFSIRHWLQQSDWIPTLEATLALDEESFRRVGDDTTGGPAVSRQLRLIRTLMRDILIGVNYLHSHGLAHTELRLENVHISPVDRHIKVGILGNAADFNGDVPSTSNAYSTMDRRQMMIAFDMRCVGFMMAKMVLQELMDPLIFAKLKSFLAKGNDPSSLREFFVTTLNTNSESGNTGVQILDRNWGAGWHLLSLLIATRPSERISCLDALKHPFLCGPRWRVAPSMDIIRWGLGSTAVKISEEYIYRMPQRQRLAHFIGLMEMLNPYPKPNCWLELLPGRWRLLYSTGKHIGLTLRQPSTRALIGNVHLTITRASESINNTSLSFTSDIRFTAITSKDWPHNKIGAAGKLQTLSQFRLIAGKRLYLKEEKKNIGKFSMGEPDAEEGLAEKLETEKWKKVVPFKEFPSSLPVAKLVSGEIEVTMNMNDHIDSPGSVIGEVRKQIPPEMFDLSKLVCGTYIDSRLLVLRCVNGSALLFTRSSLDHKSM
The following text describes a protein:
Function:
Drosulfakinin-0 (DSK 0) plays diverse biological roles including regulating gut muscle contraction in adults but not in larvae.
Subcellular Localization:
Secreted.
Sequence:
MGLRSCTHLATLFMTLWALAFCFLVVVPIPAQTTSLQNAKDDRRLQELESKIGAESDQPNANLVGPSFSRFGDRRNQKTISFGRRVPLISRPMIPIELDLLMDNDDERTKAKRFDDYGHMRFGKRGGDDQFDDYGHMRFGR
The following text describes a protein:
Function:
Transcription factor acting negatively in the phytochrome B signaling pathway. May regulate the expression of a subset of genes involved in cell expansion by binding to the G-box motif (By similarity). Activated by CRY1 and CRY2 in response to low blue light (LBL) by direct binding at chromatin on E-box variant 5'-CA[CT]GTG-3' to stimulate specific gene expression to adapt global physiology (e.g. hypocotyl elongation in low blue light). Element of a PIF4/HMR/MED14-dependent thermoresponsive process; collaboratively with its transcriptional coactivator PTAC12/HMR/PAP5, involved in the regulation of thermoresponsive growth-relevant genes (e.g. mainly involved in biosynthesis and signaling of the phytohormone auxin) leading to daytime warm temperature elicitation of MED14-dependent thermomorphogenesis (e.g. hypocotyl elongation).
Subcellular Localization:
Nucleus.
Sequence:
MEHQGWSFEENYSLSTNRRSIRPQDELVELLWRDGQVVLQSQTHREQTQTQKQDHHEEALRSSTFLEDQETVSWIQYPPDEDPFEPDDFSSHFFSTMDPLQRPTSETVKPKSSPEPPQVMVKPKACPDPPPQVMPPPKFRLTNSSSGIRETEMEQYSVTTVGPSHCGSNPSQNDLDVSMSHDRSKNIEEKLNPNASSSSGGSSGCSFGKDIKEMASGRCITTDRKRKRINHTDESVSLSDAIGNKSNQRSGSNRRSRAAEVHNLSERRRRDRINERMKALQELIPHCSKTDKASILDEAIDYLKSLQLQLQVMWMGSGMAAAAASAPMMFPGVQPQQFIRQIQSPVQLPRFPVMDQSAIQNNPGLVCQNPVQNQIISDRFARYIGGFPHMQAATQMQPMEMLRFSSPAGQQSQQPSSVPTKTTDGSRLDH
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MATEVPYFTNAENGYVPAKLAHRSAASSQPLRLLRFVVNHVIPDTVKFLLQLIPLALSGLVGLVLPSKKKSIHGHTALVTGGANGLGRALCLRLAREGCQVAVVDIDLAGAQRTVEDVRALGVKAEAFLADIANYEAVERMRLEVESKLGPVDVLVNNAGLLAVLSLSEGKPADLERIVNVNLLSHFWTIRTFIDGMKQRQRGYILAVSSILGCLPMPRTVSYVATKFAIRGMMQALQRELTMDGFGEKIVATTLFPTFIATRKELMDLLSELSLDEKLAILTPENVADSAIEGMLRGQVDVYAAPFFIRLFMYLSGILPYALTSLLIQTIMGKVPTLMDRTKKNSSTE
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKENFTRLRGELFCDHPLARYTSWRVGGKAERFYRPADLFDLQDFLTQLPSDEPLTWLGLGSNVLIRDGGIKGTVILTLNRLKELSVVNSQLVFREKSGTEDFFSGNGKTIIRAEAGVTCAKLAKFCVSQGLEDGAFFAGIPGTVGGALAMNAGAFGGETWRTVIGVETMNHQGEILKRTPDEFKIHYRQVEGLENQFFIAGYFCFNHGDPDKAKTAINALLKKRNLSQPIGKYSCGSVFRNPPGDYAARLIESAGLKGKSIGNAEVSEKHANFILNKGNASAADIEALIHYVAQHVSQIHGIQLVKEVHIIGRS
The following text describes a protein:
Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSPYISPLFSITMIMSVMLISSSGHWVFMWLGLELGTLAFIPILVWWHSSLEVEATVKYFIVQAMAAAVFFLGGMVSLSGDFMGGVNQLMGNIGDMMIMLAVVTKLGLAPFHYWVVDVVQGLNYIPGAVLLTWQKVPGLAVLTQLATCNNSSMLLLFGMVSALVGGLGGLGQTQMRKLLAFSSISHLGWLVVGCVAGSLLGLSYFTLYVVLSIPLFSILHMLNGGHLNQLRTGLMFNPLMSVLLGVGFLSLGGLPPFFGFFGKWLLLTHFVGQLLLGVSVVLITGTLISLFYYLRVSYLCIVVLGPQQIMSGLNWRKMQLSGLMSGLLVLNMLGLFLVGGASCLPK
The following text describes a protein:
Function:
Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination. In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context. Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation. Promotes cholesterol efflux by acting as a transcription coactivator (By similarity). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways. Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes. Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13. Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG. Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor. Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (By similarity). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways. In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity. In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT. Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity).
Subcellular Localization:
Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Sumoylation regulates the subcellular location. Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response.
Sequence:
MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKMKEEQERRKKKEMEERMSLEETKEQILKLQEKLSALQEEKHQLFLQLKKVLHEEEKRRRKEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLTTRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPAVQYLSQPQPQPYAVHGHFQPTQTGFLQPGSTLSLQKQMEHANQQTSFSDSSSLRPMHPQALHPAPGLLASPQLPVQIQAAGKSGFATTSQPGPRLPFIQHSQNPRFYHK
The following text describes a protein:
Function:
Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site.
Sequence:
MNTDTFMCSSDEKQTRSPLSLYSEYQRMEIEFRAPHIMPTSHWHGQVEVNVPFDGDVEYLINNEKVNINQGHITLFWACTPHQLTDTGTCQSMAIFNLPMHLFLSWPLDKDLINHVTHGMVIKSLATQQLSPFEVRRWQQELNSPNEQIRQLAIDEIGLMLKRFSLSGWEPILVNKTSRTHKNSVSRHAQFYVSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYSTFGKYVGMSPQQYRKLSQQRRQTFPG
The following text describes a protein:
Function:
Acts as an activator of both RNA and protein methyltransferases (By similarity). Together with methyltransferase Mettl5, specifically methylates the 6th position of adenine in 18S rRNA.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm, perinuclear region.
Sequence:
MKLSTYNFLTSVAIKGVKVGFPLKLTINKKEVVESEFNPTFVERILPKLDWSAVYGAAQVAELTEDIPAVQPENIVENELLLQKLHHLLFEIDVLEGQLECPETGRVFPISDGIPNMLLNEDEV
The following text describes a protein:
Function:
Participate in cytokinesis (By similarity). Necessary for microtubules and mitotic spindle organization (By similarity). Involved in primary cilium formation (By similarity).
Subcellular Localization:
Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MLAGRPGAQSAGAGVGAGPPDAPGARDGGGRPRPGAYLDMKIHLEKNLEEERQMLLQQQKLCRNRARKYFMESNRRRKAFEEKRQKQEEREYQIRERILQQRKQKFEEVTEKFQRAHVPVSQRRRAVFQNPVPPLEEALKQIQESNLKSEVNIPLFHRPATNWRAIDSALPSTLSKNDHKHQKHLVRRINRNKEMKENNIANLATNKNVFQLKLEETQKLLEDQHLSDLQKFCDEVNQITNSETLSSIDSLEAGEREEIYITLSMKPSTSTQQNSVPLQSANLQAAHLDCFDEDKLSFSKTQHINNWLTNLDAQNSQPVASFSDILIKSNVLPSWECLNSKEQNPPALSRTVGRTTRTTSDSMVFVCSPSVVALDKKGENTAESNVVRASDPTEGAVQRERPAQMESPTFKVSRAWTTAESLTQETASFSVQERPSELTWESRTASIPASSVTVLSPNLQAGGPLAENNTQIKEIDPVQCSDKLDELKNMEHERINHLNCNKEKYLFSPNFQTTCALQNSNSNDRKQKESGPSAALCNNPPDCDLPEQHSIKHSVHEQNGVRLLKSILKKESRYEHNYLRALVMKQGFKFRHQKAETVRDSIELTKQKGKGAEISKTSKKLRWFDESANLENAVDDCHPVRNRAGMAPRWLQRCHTNSGTYNLTSIPECPVHSAAGKKAKADSVPENATDLGRYEIDSVPLNSSVSLGFSFAKQAWSACRRGESKAPVHASDSKTQKTKPQRGVKFTRRTGSSKVQKGLVQNRKPTVSQPQTSSKANTVAQTQGKLIITHPPPKPPTNIKSGKNMQVSPGQSAIPEHSQNVMTQSCLSPASVLPTEYHLNQGTQESSLPFSDTCSNLPAVSPALPTPYSSECQTLAKANSNGTAFLKDGAVYCTHRSPVCEESYQSFTHRNTEEESILPWRRRINGHQNERTTDSTVTRRKQIVENKWKRLLEQKRKTSGSIGMKYTEQITHFGQNVPPSTTEQIQAPRGVKTEEVSDSTSEFLVAENLMNSSVPEDEILTAINSKHLQKPNLSQPTNVCALSAEEQKILKSLHHLDERLYYVQEAIRKNPSIKNTLQLIPLLSSQPRASLSPDVGSTVQRKY
The following text describes a protein:
Function:
Essential for the reductive metabolism of L-phenylalanine, L-tyrosine and L-tryptophan (By similarity). Catalyzes the conversion of phenylpyruvic acid to phenyllactic acid, 4-hydroxy-phenylpyruvic acid to 4-hydroxy-phenyllactic acid, and indolepyruvic acid to indolelactic acid (By similarity).
Sequence:
MKILAYCVRPDEIDSFKNFSEKYGHTVDLIPDSFGPSVAHLAKGYDGISILGNDTCNREALEKIKDCGIKYLATRTAGVNNIDFDAAKEFGINVANVPAYSPNSVSEFTVGLALSLTRKIPFALKRVELNNFALGGLIGVELRNLTLGVIGTGRIGLKVIEGFSGFGMKKMIGYDIFENEKAKEYIEYKSLDEVYKEADIITLHAPLTDDNYHMIGKESIAKMKDGVFIINAARGALIDSEALIEGLKSGKIAGAALDSYEYEQGVFHNNKMNEIMKDDTLARLKSFPNVVITPHLGFYTDEAVSNMVEITLMNLQEFELKGTCKNQRVCK
The following text describes a protein:
Function:
Catalyzes the reduction of oxygen to water; Subunits I, II and III form the functional core of the enzyme complex. Electrons originating in caldariella quinol are transferred to the binuclear center formed by heme A3 and Cu(B); Subunit I binds heme a and the bimetallic center.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLIERIKNVVWPKDTLSVVWLYTIGSIFWLGVLGIAAMNLRTFLTYDQNSPNVGELYYSALTIHGWAAMIAFVPMAAAAVIGFSLYKSKLSIIHTKQMAIFFWLSNVLLGIAMAGSPDMGWYMYPPLAIESNSQFHAFLFYTTPQLMGMAYLVMSIAVILQTAAFVTLIADAYATKPKGERLNIFAAYGVAFSIVIAVTLPALAAATLWYTLYFFANVPVNNLLWAILFWFYGHPVVYYVPFPLFGALYYYIPQYAGRSLYSEKWARWNIYLLAIGTMGVWVHHLQTWPLPIVLREWVNLSTLILATGSGLTVLNLGLTIFTSRKYDWKDPVGMGALISLIGFILAGAQALVLPENSINPLFHNSYYVVGHFHLMIWTLIIMGYTTVFLDMLRTSFAGFNFSATSSKWMRIGMIWWTAPFMGVGYAMSVAGYLGFLRRMIAYPVIFQPYNLVESFLAEIGIPGLLLTLFVGMFDALAYASKQPVFSSPSVSSFSMQVDKGELVKKIDSEKGVNNVG
The following text describes a protein:
Function:
CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
Sequence:
MKKRTKIIITLGVVGCFIAAGLIFSHKKAQATPNRPPLLVKESPVEVADLPIIATATGTLVANNQTNISPKVAGYVTKIAFSPGDFVTAGSVLIQLDNQKQKNDLAAAKADVELSELQYQRDALALKKGLILQTTVYSDKVSLDKDKALAQTDQTALQDMTLRAPFSGYLGAKQFSLGDYVTPGQKLVTLVDQQKLKVVYDLPNHFAPQLQIGQPVTVTADFLPGQRFNGKVNYVAPYVNSDSQTIETQALLNNKNGALKPGQFVTVSQTLETLKKAILIPENSLFANMNGHYVFKVKNGKAISTPVKVGERLYGKVQIIDGLKPGDHIITTGQDQIYKSGAKVKVVH
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCATDGSCSCAGSCKCKECKCTTCKKSCCSCCPVGCAKCSQGCVCKEASDKCSCCA
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
Subcellular Localization:
Cytoplasmic vesicle. Cytoplasm. Vacuole.
Sequence:
MVADLTKGILKWKSRIEFDAVGSSSYYEELKGLPPLASHKKLTQAAIFNSTKYELLQVKKDILSIYEVVSRDIDEERNQMQQIELQLKKSLKKVEHSYKNVLKQRASTNCINGNDRLLANAEKKIGSLNEELACVNDIVSDIVNNLTALNANLPKKAQLLKDDSINVAHYPLLFDFLHKSCPKSIIATSEASIHENASPSPLLEHDELPAESINSFYGENELQSDSLAPLQTHDDNISSCKKILPPKFNTTSGPSIETNFENISADGLTYTKCSLKNSISLT
The following text describes a protein:
Function:
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
Subcellular Localization:
Cytoplasm.
Sequence:
MAWRFKASKYKNAAPIVPKAEACVREICVGSYQTYGNNIAASGAFMAFNWEHTGSSVAVLPLDDCGRKSKTMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPEKGLEQSLSDPEAIFSHKQRRVETVGFHPTADGLMYSTAAGCVALFDLSTQKEIFSNNEHPEVIQSASWREDGSVLATSCKDKNVRIFDPRAAGSPIQLTAESHQSIKDSRVVWLGNQHRILTTGFDAARLRQVIIRDVRNFNTPEKTLELDCSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYLIEGLRHTGEQTKGACLVPKRALKVMEAEVNRVLQLTSNMVIPIMYQVPRKTYRDFHADLYPETTGYKTELVAGEWLNGSNQAVPKMSLDPAKREHGDEPIIPRLGPKPFSSTTGDVSFDKVFAVPLAPGSHENISNVGQDSGVEMTPAQGAKPDLIVEIEIKKKHEREPAVSGNGVQKSLTTSERRKIFEQNSESSENSTEGEDRTDADLRRNCTSRSSFAERRRIYENRSKSQVDEKPQSPVPLRREHSKVEPLKPNQQQQQQGNVIDTKRISVPEGKLMEEHRRGNGAGLKKSATEAAFSAASTKRTSTVFGKVSKFRHLKGTPGHKSTHIENLRNLSRQIPGECNGFHANQERVAVPLSGPGGKIAIFELSRPGRLPDGVIPSLVNGSNIMDFQWDPFDAQRLAVACDDGIVKIWHIEAGGLSEPTNTPAGELTAHLDKIYFIRFHPLAADVLLTASYDMTIKLWDLRTMTEKCSLSGHTDQIFDFAWSPCGRLGATVCKDGKIRVYNPRKSETPIREGNGPVGTRGARITWALEGHYIVCTGFDKVSERQISVYNAQKLSAPLNTASLDVSPSILIPFYDEDSSTLFVTGKGDSTIYCYEITDEEPYICPLSHHRCTSLHQGLSFLTKNHCDVASVEFSKAYRLTNTTIEPLSFTVPRIKSELFQDDLFPPTRITWSATLSSEDWFASNDKAAPKVSLKPEGMETLSSIQQVPAQPVKKPDHPQFGGQKSEYEINKQQEIQKSVSARMEFTTKLEQDDMEGVDENEWQE
The following text describes a protein:
Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Miscellaneous:
MISCELLANEOUS: Most specific Hodgkin disease associated antigen.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Cytoplasm.
Sequence:
MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK
The following text describes a protein:
Function:
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQGHSAGGGGWCRHCHTKLVELKRQAWKLVSGPGTTLRDPCLSALLLDKLPAPGALPACRPEAERRCDVCATHLQQLTREAMHLLQAPASHEDLDAPHGGPSLAPPSTTTSSRDTPGPAGPAGRQPGRAGPDRTKGLAWSPGPSVQVSVAPAGLGGALSTVTIQAQQCLEGMWSVSRVNSFLPPACLAEAAVAAVAVADTVRECPPVAGPDGLSKAWGRGGVCTSALVTPTPGSVGGSTGPSAAASFFIRAMQKLSLASKRKKPHPPPPPATRGTSTYPTDFSGVLQLWPPPAPPCLLRAASKTKDNPGSIGKVKVMLRIWPAQGAQRSAEAMSFLKVDPRKKQVILYDPAAGPPGSAGPRRAATAAVPKMFAFDAVFPQDSEQAEVCSGTVADVLQSVVSGADGCIFSFGHMSLGKSYTMIGKDSSPQSLGIVPCAISWLFRLIEERRERTGTRFSVRVSAVEVCGRDQSLRDLLAEVAPGSLQDTQSPGVYLREDPVCGAQLQNQSELRAPTAEKAAFYLDAALAARSTSRAGCGEDARRSSHMLFTLHVYQYRMEKCGRGGMSGGRSRLHLIDLGSCEAAAGRAGEAAGGPLCLSLSALGSVILALVNGAKHVPYRDHRLTMLLRESLATAGCRTTMIAHVSDAPAQHAETLSTVQLAARIHRLRRKKAKYASSSSGGESSCEEGRARRPPHLRPFHPRTVALDPDRTPPCLPGDPDYSSSSEQSCDTVIYVGPGGAALSDRELTDNEGPPDFVPIIPALSRHRPSKGPRDADHFRCSTFAELQERLECMDGNEGPSGGPGGTDGAQASPARGGRKPSPPEAASPRKAVGTPMAASTPRGSSGPDTHQGTPEPCKAIVWGDQREDSSAWPELLVPEKAAVSGGRRPLPSPAPPPPQLLEACRAPEEPGGGGTDGVARTPPVGMSGQVAGSPMLPGATCPRLAAGSRCPERGLLTTTVTLQRPVELNGEDELVFTVVEELSLGALAGAGRPTSLASFDSDCSLRALASGSRPVSIISSINDEFDAYTSQAPEGGPLEGAAWAGSSHGSSISSWLSEVSVCTADSRDPTPQPRFSPDSLAGLDPGGPPALDGSLGDGSSGFLGPDRPDSPGPTWGPCPGEVAAVAPSRPGREPQAGPSRWASAAQTIHSSLPRKPRTASATTRVGCARLGQSPPGRGGLFEDPWLLRVGECDTQAASAGRAPSPTLGSPRLPEAQVMLACAQRVVDGCEVAARAARRPEAVARIPPLRRGATTLGVTTPAVSWGDAPTEVVACSGSLKASPTSKKGLAPKAGFLPRPSGAAPPAPPTRKSSLEQRSSPASAPPHAVNPARVGAAAVLRGEEEPRPSSRADHSVPRATSSLKARASKVEAAHRLAGHASLERYEGLAHSSSKGREAPGRPPRAVPKLGVPPSSPTHGPAPACRSGAAKAVGAPKPPVGGGKGRGLVAGGSRALGPSVKLSTASVTGRSPGGPVAGPRAAPRAGPSVGAKAGRGTVMGTKQALRAAHSRVHELSASGAPGRGGSSWGSADSDSGHDSGVNVGEERPPTGPALPSPYSKVTAPRRPQRYSSGHGSDNSSVLSGELPPAMGRTALFHHSGGSSGYESLRRDSEATGSASSAPDSMSESGAASPGARTRSLKSPKKRATGLQRRRLIPAPLPDTTALGRKPSLPGQWVDLPPPLAGSLKEPFEIKVYEIDDVERLQRPRPTPREAPTQGLACVSTRLRLAERRQQRLREVQAKHKHLCEELAETQGRLMLEPGRWLEQFEVDPELEPESAEYLAALERATAALEQCVNLCKAHVMMVTCFDISVAASAAIPGPQEVDV
The following text describes a protein:
Function:
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MNTAEEACCVVTVSEQLFTPGSENKATSCSGVFLHFQSGIVVCSGIVFSRFINDTLPIKKDTKILYSESFKKKTKVFVDYTHFCANPTDRRKTSRREAHLVMLINCLEFQDAFHKIFKGPENWDFYSGGLDTEVLEDSRFLTWFALLKVPTSPNCPCKETIPWMKSGSLKKGCHVIACGSPFGGLCPDLFMNTISKGIVSNLAGDENALILTDARCLPGTEGGGVFISKGGTSYLVGLIASPLCWKSEEWIGLTLVCSVHLILKNMLQTEGSIKETLTGVSSQLVNGSLQAPLTANRGSGLELYPGVVLVETGWLWGSGVLLNQNLVLTCRHVVDEKSELTVKVNSGGRFHTVRGKVLYSSVVSSPYDIAIVELQEALTDKRTPRFTKHFHTGEDVVVVGYGALGSRCGPSLTSGILSRVITHQSQPVMLQTTCAVQSGASGGAVIRSDTGELLGIVSSNTRDYAAKVTYPHLNFSIPVTLLEPLLRRFAQTGDAAVFNVLDSAVEDVRKVWRLQNIQSKL
The following text describes a protein:
Function:
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Sequence:
MQQAQQKPFIPTIPAYQALKLDEDLINKCNYSIEQLMEIAGTAVAQATTHYIESTSSVSKAGVLVVCGPGNNGGDGLVAARHLSSGSMSSATVRVWLPKEPSSSVNKRMLSIAKHAGVVFIKDTNEEALHAILEFINSCESFYLVDAIFGFSFHGGPIKPPYDTVINTLLQMQTSMAIGPKTRIVSVDVPSGWSVDAQEWGLNTDKELIPDGLLRPDALISLTVPKNCSLWLPPGTAHYLGGNFLTPLLAMEYDVQEIQHYWSGVSSLFVVLS
The following text describes a protein:
Function:
[GLV9p]: Signaling peptide (root growth factor) required during root gravitropism in a PIN2-traffic dependent manner. Regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells.
Miscellaneous:
MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
Subcellular Localization:
[GLV9p]: Secreted.
Sequence:
MKKTSLKLMTLVLGFCFVIYLLQGPRGGSRNGDLLIARKLISLEPIETKNAARSLKDSISTDLEEEVDRLMEHEYPSPVKPRKRTPVHNGVRNRH