lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for ciliogenesis.
Subcellular Localization:
Cell projection, cilium. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MEVVNYTLILCLQIILLVYDIFVNAFIDLLNPENVIQLVLFILQDICLVFQLVVLCLEIFNTATSQAGFISVMMKKFAPCLLTTLLYLVLSIALCAKTLMLRWNDTTVNVYADGGFFAVYILQRLWSPIYYYTYKRTAMRLADSNFYKNTDWLRRQMTLR
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MRKRKRVLRDLEDMLCRWSDETFFAKNAALNDDDNTNRKVPPTSSPALLSFGSYRLSVHTPSSDIDCLVLAPPHLTRDDFFTTWVTALQNEARVKELHPVSGAYTPVIKFEIEGVKIDLIFARLNEPTINNHDELDEIKEMELDDTLLIGLDETSVRSINGVRVAQYLLSTLETTDKNRKNYDSATQVDNFRLTLRAVKEWARVHGLYSNVLGFLGGVNWAILVCWVCKRYPDAPASTLLQIFFKTFSTWKWPMPVLLSTQKQRPPEGVNNLPVWDPSSNFRDAKHLMPIITPCYPSMNSSYNVGEPQLRRLRDEFARASKLCSDVAFGTKKWGVLFEWNEFFQQHANYLQVDTVATNEDDFRAWFGLCEARMRLLIAGLESPGFGVRAYPFAKFFHRREDGGGGNYIASFFIALRFANKVWKVDLAPLVTDFLTVINSWDGREPTMDLMIRLVSRKDLPSFVFDAEKREEHITKPVLKPNNQQSSANRTDEDDVENQVNATTPSAKKNELDGSSTSSPSEFISPLKRTRIS
The following text describes a protein:
Function:
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity).
Subcellular Localization:
Plastid, chloroplast stroma.
Domain:
This gene contains one large insertion sequence (IS1) that divides the clpP gene into two sequence domains. The insertion sequence forms a continuous open reading frame with its upstream and downstream sequence domains.
Sequence:
MPIGVPRIIYCWGEELPAQWTDIYNFIFRRRMVFLMQYLDDELCNQICGLLINIHMEDRSKELEKKEMEKSGLFKSGTAKTKGKDTVKKENLSGGASAKRQSVEDLLTSDNDFGIEENHLLEQYTLQKITTEWLNWNAQFFDYSDEPYLYYLADILSKDFSPNQDKDSANLNFAKSSANKQAFQNPAEMTKLIKNLKNLKNFSTGSKNVKQNLDVYSPFRLLANFAPQNYNLEHPNQNLAEIYSLLKTSTQNTNQPFTKKLIDNLSHKELMNRLQSPEKLVASSEKALGRRRLKQRYVQERLGSGGLSNSKALKAYNYLDQGALNNESGRSLYRKQTERVIQEEESKKVFMIINSFGGSVGNGITVHDALQFIKAGSLTLALGVAASAASLALAGGTIGERYVTEGCHTMIHQPEGGLNGQASDIWIDSQEIMKIRLDVAEIYSLSTYRPRHKILRDLDRDFYLTAMETIYYGLADEIATNEVMHSIVEMTNQVWSYHDSKQERLLESRASLVGDSTQTQESNS
The following text describes a protein:
Function:
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
The following text describes a protein:
Function:
Precursor of the transcription factor srbA, which is embedded in the endoplasmic reticulum membrane. Low oxygen or sterol conditions promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes required for adaptation to anaerobic growth; [Cleavage-activated transcription regulator srbA]: Transcription factor that regulates sterol biosynthesis and hyphal morphology. Plays a critical role in ergosterol biosynthesis, resistance to the azole class of antifungal drugs, and in maintenance of cell polarity. Directly binds erg11A/cyp51A upstream DNA sequence at tandem repeats, called TR34 and TR46, that produce duplicated binding sites. Also mediates regulation of iron acquisition in response to hypoxia and low iron conditions via activation of extra- and intracellular siderophore production. Positively regulates the expression of the other hypoxia adaptation key transcription factor srbB. Required for the azole-sensing and response to azole stress. Binds the high-affinity sites 5'-A-T-C-G/A-T/G-A/G-C/T-G/C-A-T-3' of target promoters. Required for virulence in murine models of invasive pulmonary aspergillosis (IPA).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein; [Cleavage-activated transcription regulator srbA]: Nucleus.
Sequence:
MSTPGIGGDFQLFSPLESTRRISQGNSLSVDQSSTDVASQDWTQWMRWDDEQAFPETANASPSSPFDLAFISPSASSGREASDAMHKDFSPDISLDFKSPSLGFFPGGDLNTNVSPQPDHVGAGSLSVHSNSPLSSIGASRKRKTGSDDDGSTMTSMFKAKQAPSKKRAHNVIEKRYRANLNEKIAELRDSVPSLRASYKQANGNSGDDDDDGVTSASKLNKASILSKATEYIRHLEIRNKRLEEENTALKIRLRQLDKAADQIVTSAASVSSPSDCTVSTESGASSSPSVFSHAEDVPSDHSPTSSHPPEGLIKVPDAWKRMRAAGSNESPYSQSYIQYKKTDSHSSQSGGGRMRSHLPNKYMLGALAGLMVLEGLGTEKKTESTAKGLLAVPLNLLNRVQLPSEVYSSAAFQYFWSSWHARAISHFLMLAILVVGSAFIVFVYLFNSDPRRQYSASKVAPDVTLSSCNFRRQAWLTSIQRVGVPRHRFFHEWYVVTSRCFEYVLRCLLGWKLYSLVTGVTEEDEKGRVKTWDIAIDAQLAGGDAEISKSRLVLTIFAAGTLPRSPMRMMLKALHCRILMWRVGEPGSWTFNVSNDVARSLARYQWDLARKMNAALPKDHPDSLPSHLATLLKIDCDDVMIDTIIQRAANLTWNRPTQEGTDDDEALLDVVEEDPAIQSSLDALAAWWSSHLLQGALLRYFEASSGGPDAKKSRNVFKSKIKLALDVAPQPSAAHTRALVMMAVFFERDRVANIGSVLAALPKEKGKNKQNQASNFLDSSLPISVREEISTAVRCAMIAAIFNARATGDTSLPATFTVEKAIHWFNRLPLDPVELTLLEFAAVYHLLHILASDIDYLASSDSSAPPSPMSKASDMLSSSSDDGEDGASQRNNNIIPHPMPNLGRVASELIYWARNAYNPAFYGFTSNLVKVIETECTSLCQTAGVHVADYSCVQEEKSKAKQAIDSKRRFAGGNEEASDNLLLSDES
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.
Sequence:
MKTPLITREGYETLKQELNYLWREERPEVTKKVTWAASLGDRSENADYQYNKKRLREIDRRVRYLTKCMENLKIVDYSPQQEGKVFFGAWVEIENDDGDRLKFRIVGYDEIFGRKDYISIDSPMARALLKKEVGDLAVVNTPVGEANWYVNAIEYVK
The following text describes a protein:
Function:
Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 12 carbon atoms. In vitro, pNP-butyrate is the preferred substrate.
Sequence:
MPSLDNTADEKPAIDPILLKVLDAVPFRLSIDDGIEAVRQRLRDLPRQPVHPELRVVDLAIDGPAGPIGTRIYWPPTCPDQAEAPVVLYFHGGGFVMGDLDTHDGTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAATRWVAEHGRQVGADLGRIAVAGDSAGGTIAAVIAQRARDMGGPPIVFQLLWYPSTLWDQSLPSLAENADAPILDVKAIAAFSRWYAGEIDLHNPPAPMAPGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPVEVHNAQTLVHGYVGYAGVVPAATEATNRGLVALRVVLHG
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MKYGQVVVGPAGSGKSNYCKMMKEFMKIKKRNCYVVNLDSACEEYYYERKKKPINTTYNIEKELNDYYDTIYDIDIRNYVEVNNLMEEQNLGPNCALLRSVEILYENSYLLEDELNNYDDDDNYFIIDTPGQIELYTHTDYFKKILNIFSEQNIRLVIVFLIDISFISSNTKLLSAYLTSLSTMINFELPHINILTKCDLLISKNYYHEFNNFKNRNNFFYQKQLYKKINQKLIYYKKQGTYQKNNAEENDLYNNNHNLRHMKNNYHNLNLTNQEHNQNNDEDDKSFLEEIEFINNTKSFKDEFVLWSDVENTSVSSYSSFNSNQKENNNSIYNSSDEQKSVISDECEESIYKKNYEKLNDILSLDPHDIIITANKCMSKKYYKLNNAFANIIEDFNLVSFLPLNIYDDDNVDFIINSIDMIIQYGEDKDVNDNYDMFS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAVVLDPQVQAPRAQDGFLIVKLEDDSHWHQESFLHRNVHSPEASCQRFWQFHYQEAAGPREALNQLRELCRQWLRPEKCTKEQILELLVLEQFLTVLPREIQTWVREQHPENGEEAVTLVENMQREPGRSAMKVPVVMKGQEVLTEMVTTTESVPNSLSIHLKQTQTKSKCTFQENAERLHLEPEKELSCDPKIEPHSLQESALSASQVLDLPVEASSGNQEMVGKSQDLVTFGDVAIYFSQEAQGQLDSAPQDFCQDQTQENENGVSQRFPIPRTSMISQIEQGEKLQNLDLQGCKEKENSRDSRMVGERTKIGQAPVMKKVKHWEELERQGLDDEKVAGVHWGYEETKIFLGILSESWIYEKLRTCHRNRQVYRIVAERLRERGFLRTLEQCRYRFKNLQTNYRKARSTHTPGTCPFYEEMDALMSPRVAVTAPEVEGDLGQGDHDIESEELERDNWEHEDIAMAGVVLEGGSRQLDLSHPAASLEELHSGAVSEDSDGEELGNDEPSESPGTQTLFRSATGVHWGYEETKIFLGILGEPRIYEKLRTCHRNRQVYRIVAERLRECGFLRTLEQCRYRFKNLQTHYRKARSGHTPETCPFYEEMDALMSPWTAITPLDVLEMAGGLLKGKVESKENTNWENPETVTEVGNHVEVEEPPKEVKNFKLEAVFQNSSELPIHKPDSNPKPEVGEELQNVNFHDFKEIQRTSHTDFEMTGKHEKNPSQEISEGVELHATSLGSSKGNASHYLNWKKAQEGEYRTERQWEMLPGEEQGPPSPQERNLGNFIGLQGTYIGENPNTCSECGKNFSQSSHLAVHRLAHIGEKKLHDCEECGKTFSRSSHLICHQRIHTGEKPYKCPECRKGFSDHSNLTAHQRIHTGEKPYKCSECWKSFNQSSSLIMHQRIHTGEKPHKCSECGKSFTNSSHFNAHWRTHTGEKPYQCPECGKRFSKSSTLTSHQRIHTGEKPYECLECGKSFSDRSNLITHRRIHTGERPYKCGECGKSFNQSSSLIIHQRIHTGEKPYECNECGRRFNNSSHFSAHRRTHVGEKH
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MDPSRETFDGSTRDSYKPPNGAEMMGQSELNTQNRIPYNTSANNRNWQIPLYWQQRGNEFQASPPPPLGYVTPEYGATGTPVNANNASRVDYATTAANVPEEYANDYSSELAYIHNVNDMPHVDGLSNHSPATQPDLFETPAQSDPILFSSYPHAAQARVDPSISKDLYNMVPRPDANTVSPHAARSASSLPVPKEASETPFRDASTDLFDEHAHAAPMHSSISISTLLSDSDRYEPHVSLTENISPVMAPSIDARLSQTILRGLPPAQKLSPNSSQSQITHNRRKHKLPLNATTNNSVVLTPDTSPLLDSDEVVSDDDSNEQQTMMMKFNYLQHLRNKRDEAVHAEKRRLLDIRGSIHDRLVCRYENRYNKLHASEYNHHHDWAVRQAIREEVAAVEAAKIRADEEKKKKEREEQVRLLQESADKDAEMNEASTATSENEDLKDDLSLADLSSKKTANSQATENNNTPSKAKVKAESKVRSKAKSDKSRAKLSSDTNKDSEKNDNNDASLQSAGVASDGESSPETPLTKASKSKKAKASKLANDTSKNANGETKSTPKKSKKKTSKAQQEANSTTAEGKEKLSGDSTETGNSTNKEASTEDTKANATASAPNKKKKTVETLQQQVIKEIARKEIPRVYKIIQQNQYNRSTNARKTSQLCGREARRWQFRTIKNNKDMQTKAKRAMRETMVFWKRNERVERDLRKKAEREALDRAKKEEELRESRRQARKLDFLITQTELYSHFVGRKMDREQDLPSATNTASVSEINFDSDEEEDIRRLAVESAQEAVQKAREHSQLFDANRQQSPNNSSSDMNEGEMNFQNPTLVNAFEVKQPKMLMCKLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISVMAYLAETHNIWGPFLVIAPASTLHNWQQEITRFVPKLKCIPYWGSTKDRKILRKFWCRKNMTYDENSPFHVVVTSYQLVVLDAQYFQSVKWQYMILDEAQAIKSSSSSRWKSLLAFKCRNRLLLTGTPIQNTMQELWALLHFIMPSLFDSHNEFSEWFSKDIESHAQSNTQLNEQQLKRLHMILKPFMLRRVKKNVQSELGEKIEKEVYCDLTQRQKILYQALRRQISIAELLEKAILGGDDTVASIMNLVMQFRKVCNHPDLFEREDVRSPLSLATWSKSIYINREGNFLDVPYNTRNFITFSIPRLLYEQGGILSVPGLNTSRGFETKYLYNLMNIWNPEYTNDSIKSNPEGSPFSWLRFVDESPQTLFQTFQNPVVHYLDEAEASSSLKEEQLCRQEFCYGKDYSNVRKMLLLPKSITKVDVLGSDFKEDSPFYHLTHVLEESDSQLDLTLLDSVLVQRASAPPIDIYCPGSRQFTVLQSRFQRDHLWSHYLYQPLKGEEDLIINNQAVSKLPIPRKPLLPSFGIAKGSYSNVRIPSMLRFIADSGKLSKLDKLLVELKANDHRVLIYFQMTRMIDLMEEYLTFRQYKYLRLDGSSKISQRRDMVTEWQTRPELFVFLLSTRAGGLGINLTAADTVIFYDSDWNPSIDSQAMDRAHRIGQQKQVTVYRFITRGTIEERIVIRAKEKEEVQKVVISGGETRPTKQMDLKGNSREMVSWLLEE
The following text describes a protein:
Function:
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MQEIESLHQSVLLQEVLQAFMPLEEGVLIDCTLGLGGHSKALLSQKPHLKLIGIDKDKFAQEIAKERLKAFEGRYNLLSGGFAKRFKEALETHNKEIKGVLVDLGVSSLQLDDDNRGFNFHSHTLDMRMDLESELNAQKVINSYPIVALEKIFRDYGEIKEYKKIAHKIAERRAKKPFKNAKDLSEFLSSFSKNKKIHPATLVFQAVRIEVNSELEELKEFLQCARNLKGAILCVISFHSLEDALVKNAFKDYAKNCICDPSSFKCACSNNHALGEILTKKPITPSPEEIKNNRRSRSAKMRVFQFKP
The following text describes a protein:
Function:
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A.
Subcellular Localization:
Lysosome.
Sequence:
MISLEHTGVLLLLTLLAVGTLAQTQVLEASVWPWPQNIRVSPNQTFALNPSLFHFQYSAASAVQPGCSVLDEAFVRYLRIIFGTGPWLSPDRPDLKITVKNSLDVLVAVPGCDLFPEMNSLENYTLTLSNQQFVLKSHTVWGALRGLETFSQLIGRSAEGMFYVNCTDIVDFPRFPHRGLLLDTSRHYLPLQTILETLDVMAYNKFNVFHWHIVDDPSFPYESVNFPELSRKGSYDPASHIYTMEDVKTVIEYARLRGIRVLAEFDTPGHTLSWGKGIPGLLTPCYSGSVPSGSYGPVNPILNRTYEFMASFFQEISDVFPDFYLHLGGDEVDFTCWQSNPDIQAFMKEKGFQNYEQLESFYIQKLLNIVSSYRKGYIVWQEVFDNDVKLSPDTVVHVWRETKPVPYAMEMKNITKAGYRVLLSSPWYLNRISYGQDWQKIYSVEPLDFEGSPEQESLVIGGEACMWGEFVDMTNLTPRLWPRAGAVAERLWSSKSVNDTKLAYARLANFRCELLRRGVQAQPLFVGFCEHDFYH
The following text describes a protein:
Function:
Involved in stress response.
Subcellular Localization:
Cytoplasm.
Sequence:
MHYKHILAAIDLSPRSQEVIDRAAEVAASNNATLDVVHVIEHSPVAYGGEFSIPINVNLEQTIESEARKALTELCHTVKVPSERQHTLSGVVKHMVIELAEKLNIDLIVVGTHGHHGLDKLLGSRANAILHVATCDVLAVWMKE
The following text describes a protein:
Function:
Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration.
Subcellular Localization:
Secreted.
Sequence:
MQLCGFLFLAVLILAAGTTEAGKNKKEKGKKGGSECEDWHWGPCTPNSKDCGVGFREGRCNDETRRLKCKVPCNWKKEFGADCKYKFESWGPCDGASGTKARQGTLKKALYNAQCQETIRVTKPCSPKAKPKSKAKKGKGKD
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MGNNPSKKSTASTPTTTNKKKNEPTTNTGNVTTNNTPTATPQNNVAIKPETNQTSVNNVNNKVSISSNNSNSNNNKIEDKGKRIEDFFDKYKDEDDNNVIGPDGITRLCKDLGVEPEDVVVLVLAWHLGAKQMGYFSKAEFTQGLSKLNIDSLQKLQQHLPTFKKDLDNPNNFKDIYRFAFIFAKENENNKILDLESACSMLQLVLADRYPHTEKLQEFLMQQKSYKVLNMDQWLSILEFSKIINANCSNYDENGAWPVLLDEYSEWRKQTDPK
The following text describes a protein:
Function:
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MDFYSNLPVDATATPTLFEITSSHEIDGLLKPTFQYLSANAIQRAPTRARIMLHSRFDELYALLKLLLEYYHLDKYNATFIEKYYGLQRESVAGGVAGARLSRGQVAVVLCEKVAAVYVRDKLDQLHGRLYGRRLTAKLSAWERWFVRWYPHLKKLVAVASLLCKLRYLSGRSRATSVLDYLAGIQYARLSQPAGADAVAAAGAALARPVRTNWPRIRELIYRFLKTTGGALGVLTSELFPTFIFTVRLLQQWSQQPTKKQDPWDTLSSAPPAPRPEVLVHGDAEATDAAEGEPYISVRCPVCRSAVSNPGVLQTGYIACYPCAVRYVEKHGKCPVMQTPLLGGPRGIRKLIC
The following text describes a protein:
Function:
Catalyzes the hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose in xyloglucan degradation, leading to remove the backbone 'G' units.
Miscellaneous:
MISCELLANEOUS: Gut bacteria supply the human body with energy from dietary polysaccharides through glycosidases that are absent in the human genome. Xyloglucans are a ubiquitous family of highly branched plant cell wall polysaccharides present in the vegetables we consume. Enzymes involved in xyloglucan degradation mediate the conversion of otherwise indigestible plant polysaccharides to short-chain fatty acids.
Subcellular Localization:
Periplasm. Note=Periplasmic localization is predicted by analogy with the archetypal sus locus.
Sequence:
MIIGIMKTFLLTICFLSVQTGMVAIAQDKEQTPVYLDDTQPIEVRVQDALNRMTVEEKTRLSYAQGKFSSPGCPRLGIPELWMSDGPHGVRAEINWNDWGYAGWTNDSCTAFPALTCLAASWNPLLAAKYGYAIGEEARYREKDVLLGPGVNIYRTPLNGRNFEYMGEDPYLASELCVPYIQGVQKNGVAACVKHYALNNQELWRGHIDVQLSDRALYEIYLPAFKAAVERGKAWSIMGAYNKVRGTHATHHKLLNNDILKGEWNFDGCVITDWGAAHDTYEAAMYGLDIEMGSYTNGLTSESEFGYDDYYLGKSYLKMVREGKIPMEVVNDKAARVLRLIFRTAMNRRKPFGALTSEEHYRTAYEIATEGIVLLKNGTGKKQPALLPVPQGKYKRILVVGDNATRNLMLGGGSSELKVQKVISSLDGIKAKFGDGVVYAQGYTSGRPMYGRADVIPQVTVDSLRNDAVEKAMNSDLVIFVGGLNKNHFQDCEGGDRLSYELPFAQNELIEALLKVNKNLVAVIVSGNAVEMPWVKEIPSIVQSWYLGSVGGEALADVLSGEVTPSGKLPFSYPVKLEDCPAHFFGEISYPGDSIRQEYKEDILVGYRWYDTKKVQPLFPFGYGMSYTTFEYSKPVISAQTMNTDGSIDVSVKVKNTGKVAGKEIIQLYIGDEECSVLRPVKELKDFRKVQLLPNEEKEVKFTIKPEALQFFDDKQRTWVAEPGKFKAYIAASSSDIRGTVTFEYIQ
The following text describes a protein:
Function:
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Sequence:
MIVGRVWRLGDDITTDHIIPGRLKYSSGSLEDMKKYVFNDLIPNFHESVKPGDVIVAGKNFGYGSSREHAARLLKIVGIGAVIASSFARIFYRNAVNVGLPVIEAEIEADQWDIVKVHLEEGKIENITKSLVFTFKPFPREILEIFEEGGIVEYFRRRGKFPWE
The following text describes a protein:
Function:
Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (Probable). DNA demethylase that is indispensable in both male and female gametophyte development. Involved in the regulation of DNA methylation in the promoters of RISBZ1/BZIP58 and DOF3/RPBF, two transcription factors that functions synergistically to positively regulate genes that are key players in the development of aleurone layers. Active DNA demethylation carried out by ROS1A in rice endosperms may restrict the number of aleurone cell layers.
Subcellular Localization:
Nucleus.
Sequence:
MQDFGQWLPQSQTTADLYFSSIPIPSQFDTSIETQTRTSAVVSSEKESANSFVPHNGTGLVERISNDAGLTEVVGSSAGPTECIDLNKTPARKPKKKKHRPKVLKDDKPSKTPKSATPIPSTEKVEKPSGKRKYVRKKTSPGQPPAEQAASSHCRSELKSVKRSLDFGGEVLQESTQSGSQVPVAEICTGPKRQSIPSTIQRDSQSQLACHVVSSTSSIHTSASQMVNAHLFPPDNMPNGVLLDLNNSTSQLQNEHAKFVDSPARLFGSRIRQTSGKNSLLEIYAGMSDRNVPDLNSSISQTHSMSTDFAQYLLSSSQASVRETQMANQMLNGHRMPENPITPSHCIERAALKEHLNHVPHAKAAVMNGQMPHSYRLAQNPILPPNHIEGYQVMENLSELVTTNDYLTASPFSQTGAANRQHNIGDSMHIHALDPRRESNASSGSWISLGVNFNQQNNGWASAGAADAASSHAPYFSEPHKRMRTAYLNNYPNGVVGHFSTSSTDLSNNENENVASAINSNVFTLADAQRLIAREKSRASQRMISFRSSKNDMVNRSEMVHQHGRPAPHGSACRESIEVPDKQFGLMTEELTQLPSMPNNPQREKYIPQTGSCQLQSLEHDMVKGHNLAGELHKQVTSPQVVIQSNFCVTPPDVLGRRTSGEHLRTLIAPTHASTCKDTLKALSCQLESSRDIIRPPVNPIGPSSADVPRTDNHQVKVSEETVTAKLPEKRKVGRPRKELKPGEKPKPRGRPRKGKVVGGELASKDSHTNPLQNESTSCSYGPYAGEASVGRAVKANRVGENISGAMVSLLDSLDIVIQKIKVLDINKSEDPVTAEPHGALVPYNGEFGPIVPFEGKVKRKRSRAKVDLDPVTALMWKLLMGPDMSDCAEGMDKDKEKWLNEERKIFQGRVDSFIARMHLVQGDRRFSPWKGSVVDSVVGVFLTQNVSDHLSSSAFMALAAKFPVKPEASEKPANVMFHTISENGDCSGLFGNSVKLQGEILVQEASNTAASFITTEDKEGSNSVELLGSSFGDGVDGAAGVYSNIYENLPARLHATRRPVVQTGNAVEAEDGSLEGVVSSENSTISSQNSSDYLFHMSDHMFSSMLLNFTAEDIGSRNMPKATRTTYTELLRMQELKNKSNETIESSEYHGVPVSCSNNIQVLNGIQNIGSKHQPLHSSISYHQTGQVHLPDIVHASDLEQSVYTGLNRVLDSNVTQTSYYPSPHPGIACNNETQKADSLSNMLYGIDRSDKTTSLSEPTPRIDNCFQPLSSEKMSFAREQSSSENYLSRNEAEAAFVKQHGTSNVQGDNTVRTEQNGGENSQSGYSQQDDNVGFQTATTSNLYSSNLCQNQKANSEVLHGVSSNLIENSKDDKKTSPKVPVDGSKAKRPRVGAGKKKTYDWDMLRKEVLYSHGNKERSQNAKDSIDWETIRQAEVKEISDTIRERGMNNMLAERIKDFLNRLVRDHGSIDLEWLRYVDSDKAKDYLLSIRGLGLKSVECVRLLTLHHMAFPVDTNVGRICVRLGWVPLQPLPESLQLHLLEMYPMLENIQKYLWPRLCKLDQRTLYELHYQMITFGKVFCTKSKPNCNACPMRAECKHFASAFASARLALPGPEEKSLVTSGTPIAAETFHQTYISSRPVVSQLEWNSNTCHHGMNNRQPIIEEPASPEPEHETEEMKECAIEDSFVDDPEEIPTIKLNFEEFTQNLKSYMQANNIEIEDADMSKALVAITPEVASIPTPKLKNVSRLRTEHQVYELPDSHPLLEGFNQREPDDPCPYLLSIWTPGETAQSTDAPKSVCNSQENGELCASNTCFSCNSIREAQAQKVRGTLLIPCRTAMRGSFPLNGTYFQVNEVFADHDSSRNPIDVPRSWIWNLPRRTVYFGTSIPTIFKGLTTEEIQHCFWRGFVCVRGFDRTSRAPRPLYARLHFPASKITRNKKSAGSAPGRDDE
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MGDWKGYISAVLRDQRIDDVAIVGHSDNRCVWASRPGGLLAAISPQEVGVLTGPDRSTFLQAGLCVAGRRCCVIRDHLLAEGDGVLDARTKGLDGRAICVGHTPRALLVLMGRRGVHGGILNKTMHELIHGLRSQGT
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
Subcellular Localization:
Nucleus.
Sequence:
MVQQSRDASSHPDEPPAKRRTLQIKLGRPRPSSDFSHPEQPSPSLNRSRPGHSHAIRISLKRKSTVSESQAAPSRLAAYPAEDQDEDDDRDEDENEDDDQDVGTLNASEQDDDDREPDNAEDDQQDDDGEEEQDEEEEDQQDDLDENQDGEGDNVDSVARGNAASNPRTRGLNGAFRSISAGTANPSRRPIKRLRSKGLYEALPKLIENLQRRDSYKFFCEPVNPDEVPGYSDVIKSPMDFGTMQRKVQDRLYSHMDQVKADFQLVISNAMTFNPEGTLYYNEAKRIAAWGNRAIEREGMAVNDNGRAGLKGEEMRRQRRLEREAATVTSVGVLEGPSSVDDGHSRRPLRGSTANQQPALDDASQQRVGDQNASEELTTRSAARGSRFAFSAGVEALMEAARVTSQARQRAAIALGLTGGTLTREDSVQPGAGVKAEGNADMDIDDDEDENVSDEEGGIRANVTRERSVTVDCAAGVNGRQCGSSQPCGTPSTPLGQRQASPGALRRRLAAVTGTPAQALASPMGALSAVAGGTSRASKHSKHRKRLSAPGTPKRLLARTGLTGSGTPLASVASSSGAATDSAGLTLDPAATAAAAAQLIADLSQTQIQTTAASYSFEDNGSINPEDIDDLQAFLTLHRSGKHILMPTIESLHPIPFIPGDYITNSGAEGKAKDQDKEQERSKEKEKAKDKGATDDGDDEDEDGKGDTREKGDKDPLSTLPPSRPGAPDPLYSAIAPEPEPLQSNLSHDVEPLPRHFRNLPFHAPSLPTRSLQDQASYGVLHSWDNPAYAEALKNDKRPKKQKDKEREKERETLEDWSYFRPTLTRLLEITDLGPFTALVPTTEQDQRSEPAKMMAKGKTARATKGAQAVTSPTPAFSTTLLGEQGIQAIKTELGQSEEGLRQAQGILMRYIGAAKAGIATTRNGSWTQAEQQAASRYVSDTVYAGVTGNAYVRSVGEFVGGAIHHAMLLDEADDAEEQQIAEAEKKLLLAAAMRKVTETEATPEPSAASRRGPFMWRDTTEEAAGTATPSVGGEPDTSCVAHTTALGTWMAELEDSVVKPVISEVLEDLEKGETKLAPLRKPLAHVVEEEVIRPITGHTLDVLHLVAVLLEAHGFEELNVDEIEARLLRNKMRRHGINGGEVQSHAAPRAQAVAEPASATNTFLAPSQPPIPFQAELDWLQGQPDLSKLLDEARLDVDSLGSIVNYIVQSA
The following text describes a protein:
Function:
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MIFGKTHFLSYNILRYSTKRWMNRHSYSHHAKCTVAQLLKQNLLTFENQRIQPEEELKENLTKVVNYFQAPIDVAVGYGSGVFRQAGYSQKENPMIDFIFQVEDPVKWHKINLQQNPSHYSFVKNFGPGFVSTLQESFGTGVYYNTHVEVEGNIIKYGVTSKKDVYEDLKNWNTMYLAGRFQKPVVILKGEDEFYKENSYNLSSALHVGLLMLADRFTEFDLYKTIVSLSYLGDIRMSFFAENPRKVENIVSKQIAFFRKLYLPLLYAEPGVHFIESSEVLKSMDPSDNSRYLSFHQNITKDSISRLLNGLPLNLVKILGLKPDTSSFEKCAELMLTNQISTRSLLISKSIKKLTSFSILTQSIKGIFTAGVIRSFVYVYAKLKKGLLSKWGR
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDGANHSMVSEFVFLGITNSWEIQLLLFLFSSVFYVASMMGNSLILLTVTSDPHLHSPMYFLLANLSFIDLGVSSVTSPKMIYDLFRKHKVISFSGCITQIFFIHIIGGVEMVLLIAMSFDRYVAICKPLHYLTVMSPRMCILFLVTAWIIGLIHSLVQLAFVVKLPFCGPNVLDSFYCDFPRFIKLACTDTYRLEFMVTANRSSSKALSTLSTHVMVVILFFGPCIFVYMWPHPTSHLDKFLAVFDAVLTPFLNSVIYTLRNKEMKMAMRKVFSQIFIYRRIL
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB21 is involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10.
Subcellular Localization:
Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Cell projection, neuron projection. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells.
Domain:
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Sequence:
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQPGTARRGVQIIDDEPQAQTSGGGCCSSG