lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects; Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.
Sequence:
MPRVLVIGAGASGLAAVKACLEEGVDVVCIEKTSDVGGLWTYREENVDGVASIMYSTTTNTSKDLSAFSDFPPPPDFPNYMHNSLVARYLECYADAFGLKRHIRCSHVVLRLSPASDHEQTGCWDALIQNVASGKTWTESFNAAMVCTGYDVAPVLPSFPGLVDRFRGRVLHTRDYKRPAGFEGKRVLVVGLGNSGADVAVELSAVADSVYVSTRRGCWTIPRVGPRGEPFDTVNVRRVWNWLFHLLPFGLVCHVSENEANARFDHAAYNLAARHRIHEQHATISDLLPSKILNGTVVVKGDVVSFTEDGVLLQDDPTRAVPVDVVVLATGYGAHFPFIDSKLVPVRDNRLRLYKFVFPPHLERHTLAFIGGVQPEGSLFPISELQSRWAVGVFVGRYALPGRAAMDADVDLKERHIGRRYIEGSRHARQVDWIDYMDEVAELVGCRPRLLRLLFTDPKLLWACVFGPCLPYQYRLHGPRPWPMARQEILSFQENYRRGLKTREVPWKTEGERRSFVKLTLMVLSLVATAAKVKIVREFLVKYVTLLWGIRLKIRHRLRLGKLYLSA
The following text describes a protein:
Function:
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA
The following text describes a protein:
Function:
Required for non-photochemical quenching (NPQ), a mechanism that converts and dissipates the harmful excess absorbed light energy into heat and protect the photosynthetic apparatus from photo-oxidative damage. Seems involved in the activation of NPQ, possibly by promoting conformational changes required for activation of LHCSR3-dependent quenching in the antenna of photosystem II (PSII).
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MAMTLSTKAFAQRGVSARKNTVRVYAASTKVNPKLASKTEVERFKQATGLPAPAINGKQFPLKLGFTKTNELFVGRLAMVGFSASLIGEILTGKGALAQFGYETGLNGIEVDGLVIGLIAFNLIAAVLPTSQTFVPEEQDTISERPAGPLQDPRITLLEPKKFFGVQGFGFTKENELFVGRAAQLGFAFSLIGEAVTGKGALAQFDIETGLSLRDTEFGLVVFILFLLFAAINEGSGKFVDEESA
The following text describes a protein:
Function:
Has bactericidal activity. Potent activity against E.coli, L.monocytogenes, S.typhimurium and S.pyogenes but mot against S.aureus; Has bactericidal activity.
Subcellular Localization:
Secreted. Cytoplasmic granule.
Sequence:
MRILQLLFAIVVILLLQDAPARGFSDSQLCRNNHGHCRRLCFHMESWAGSCMNGRLRCCRFSTKQPFSNPKHSVLHTAEQDPSPSLGGT
The following text describes a protein:
Function:
Probable component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. May form a homodimer separately from exosome complexes and function in DNA cleavage process. Binds double-stranded DNA (dsDNA) and single-stranded RNA (ssRNA), and possesses hydrolytic DNase and phosphorolytic RNase activities in vitro.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEESRADGRNPNQLRPFSCTRNPLDRAHGSARWAQGDTIVLAAVYGPKPGTRKGENPEKASIEVVWKPMTGQIGKQEKEYEMTLKRTLQSICLLTVHPNTTTSVILQVVGNDGSLLPCAINACCAALVFAGIPLKHLAVAIGCGVLEDGEVILDTNKAEEQQLKSFAHLVFPNSRKSASSKEPNQKEEDSERGLITSITHGVMSEEDYFSCIERGLAASSRISDFMRTTLQKQAPGDV
The following text describes a protein:
Function:
Involved in the biosynthesis of albonoursin (cyclo[(alpha,beta-dehydro-Phe)-(alpha,beta-dehydro-Leu)]), an antibacterial peptide. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP-independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Phe-L-Leu) (cFL) as major products from L-L-phenylalanyl-tRNA(Phe) and L-leucyl-tRNA(Leu). AlbC can also incorporate various nonpolar residues, such as L-phenylalanine, L-leucine, L-tyrosine and L-methionine, and to a much lesser extent L-alanine and L-valine, into cyclodipeptides. Indeed, ten possible cyclodipeptides composed of L-phenylalanine, L-leucine, L-tyrosine and L-methionine are all synthesized to detectable amounts by AlbC.
Miscellaneous:
MISCELLANEOUS: The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site Ser-37 and the L-phenylalanine residue.
Sequence:
MLAGLVPAPDHGMREEILGDRSRLIRQRGEHALIGISAGNSYFSQKNTVMLLQWAGQRFERTDVVYVDTHIDEMLIADGRSAQEAERSVKRTLKDLRRRLRRSLESVGDHAERFRVRSLSELQETPEYRAVRERTDRAFEEDAEFATACEDMVRAVVMNRPGDGVGISAEHLRAGLNYVLAEAPLFADSPGVFSVPSSVLCYHIDTPITAFLSRRETGFRAAEGQAYVVVRPQELADAA
The following text describes a protein:
Function:
E2 conjugating enzyme that catalyzes the covalent conjugation of the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to the amino group of phosphatidylethanolamine (PE)-containing lipids in the membrane resulting in membrane-bound ATG8-like proteins which is one of the key steps in the development of autophagic isolation membranes during autophagosome formation. Cycles back and forth between binding to ATG7 for loading with the ATG8-like proteins and binding to E3 enzyme, composed of ATG12, ATG5 and ATG16L1 to promote ATG8-like proteins lipidation (By similarity). Also plays a role as a membrane curvature sensor that facilitates LC3/GABARAP lipidation by sensing local membrane stress associated with lipid-packing defects as occurs with high molar proportions of conical lipids or strident membrane curvature (By similarity). Interacts with negatively-charged membranes promoting membrane tethering and enhancing LC3/GABARAP lipidation (By similarity). Also acts as an autocatalytic E2-like enzyme by catalyzing the conjugation of ATG12 to itself in an ATG7-dependent manner, this complex thus formed, plays a role in mitochondrial homeostasis but not in autophagy (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region works in concert with its geometry-selective amphipathic helix (AH) to promote LC3-PE conjugation activity only on the target membrane; The LC3 interacting regions (LIR) motif mediates interaction with GABARAP and MAP1LC3A in a beta-sheet conformation-dependent manner. The LIR motif is required for LC3 lipidation and ATG3~LC3 thioester formation; The membrane-curvature-sensing motif targets curved membranes.
Sequence:
MQNVINSVKGTALGVAEFLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWKWASGEEAKVKPYLPNDKQFLLTRNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTFHNSGVTGVTEAVREISLDNKDNMNMNVKTGACGNSGDDDDDEEGEAADMEEYEESGLLETDDATLDTSKMADLSKTKAEAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEDRQPLTVDQMYEDISQDHVKKTVTIENHPNLPPPAMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM
The following text describes a protein:
Function:
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential to colonize and establish infection in gastric mucosa as a result of its essential role in motility. Has effect on flaA gene transcription.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MAIGSLSSLGLGSKVLNYDVIDKLKDADEKALIAPLDKKMEQNVEKQKALVEIKTLLSALKGPVKTLSDYSTYISRKSNVTGDALSASVGVGVPIQDIKVDVQNLAQGDINELGAKFSSRDDIFSQVDTTLKFYTQNKDYAVNIKAGMTLGDVAQSITDATNGEVMGIVMKTGGNDPYQLMVNTKNTGEDNRVYFGSHLQSTLTNKNALSLGVDGSGKSEVSLNLKGADGNMHEVPIMLELPESASIKQKNTAIQKAMEQALENDPNFKNLIANGDISIDTLHGGESLIINDRRGGNIEVKGSKAKELGFLQTTTQESDLLKSSRTIKEGKLEGVVSLNGQKLDLSALTKESNTSEENTDAIIQAINAKEGLSAFKNAEGKLVINSKTGMLTIKGEDALGKASLKDLGLNAGMVQSYEASQNTLFMSKNLQKASDSAFTYNGVSITRPTNEVNDVISGVNITLEQTTEPNKPAIISVSRDNQAIIDSLTEFVKAYNELIPKLDEDTRYDADTKIAGIFNGVGDIRAIRSSLNNVFSYSVHTDNGVESLMKYGLSLDDKGVMSLDEAKLSSALNSNPKATQDFFYGSDSKDMGGREIHQEGIFSKFNQVIANLIDGGNAKLKIYEDSLDRDAKSLTKDKENAQELLKTRYNIMAERFAAYDSQISKANQKFNSVQMMIDQAAAKKN
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response.
Subcellular Localization:
Mitochondrion. Plastid, chloroplast.
Sequence:
MAMRQAAKATIRACSSSSSSGYFARRQFNASSGDSKKIVGVFYKANEYATKNPNFLGCVENALGIRDWLESQGHQYIVTDDKEGPDCELEKHIPDLHVLISTPFHPAYVTAERIKKAKNLKLLLTAGIGSDHIDLQAAAAAGLTVAEVTGSNVVSVAEDELMRILILMRNFVPGYNQVVKGEWNVAGIAYRAYDLEGKTIGTVGAGRIGKLLLQRLKPFGCNLLYHDRLQMAPELEKETGAKFVEDLNEMLPKCDVIVINMPLTEKTRGMFNKELIGKLKKGVLIVNNARGAIMERQAVVDAVESGHIGGYSGDVWDPQPAPKDHPWRYMPNQAMTPHTSGTTIDAQLRYAAGTKDMLERYFKGEDFPTENYIVKDGELAPQYR
The following text describes a protein:
Function:
Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development.
Subcellular Localization:
Nucleus.
Sequence:
MAESSDIPNGTYTLTLGKSFEVKGRKSDPKAEQFHTLRYDFKPSSVSNNADTFIAFGNSGDVHVSVPSEGDNMTVYKGSKKEAKPKECLLFFDKKTNTVRLEKITSNINVKKTRDLDQGTELALKRGIERLRTSSNNQRSGPSSPEEKAKIQKQMQRDTSDSSSDSDGSSDSDKSNGDSSDDEDESEKILLEEMKKPKPYTEREPAPPSSSNTYNHKESHVAPYISSSGNKNKDSEEKYGLALSESSDEDD
The following text describes a protein:
Function:
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Sequence:
MSRAPDRIAACFDALRHSGRKALIPFITAGDPSLEATVPVMHALVRAGANIIELGVPFSDPMADGPTIQRSSERALGRGAGLAYVIEAVQEFRREDATTPVVLMGYLNPIEIHGTRRFAETAVAAGIDGVLLVDLPPEEADETRAIFTEVGLALIALASPTTGEARLDMLCSTAQGYLYYVSFSGVTGAADRLDTHAASDRLRQLRARAGAPVVAGFGIKDAASAAAMAVDADGVVVGSALVAALADASDVRSARKRAEDFLQPLRQALDAG
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MVEILLLPNERFSNIEGYIFYPSRDVLPLEDVVLSPEIKGKRIEILWRLLNGENLKIATTLKALTEKVFSPDFLRENSLMIARSTKLTLSPEKLVEMGYELVFTVQNVGEFAIRGDIIDIYSPGNDFPVRIELFGDEIEEIRFFKVDTQRSFQGVDKTLILPFVDFYGESTLLDFLKTDARFICEDLQKVLDEYRKFRKEMRDLLKERYNDFFDERVVEVILKNVEKGSAPLSTRVEKKESLPILDVDEIEEGGLVVHREHGIAIFEGIVRLKGVLGERDYLKLKYEDAILYVPIEKIDRVHKYIGDPSQVKLDRMNRGKWKQTLKKVREDIEKKIKELVELYMKRQEAQGLSLPGDPELEEKFAESFPYIETPDQQQSIEEVLSDLASEKPMDRLLCGDAGVGKTEVALRAAFRAVASGKQVAVLVPTTVLARQHYENFKERMEPFGVKVELLDSSRTAREKKEIIEKLKKGEIDIIIGTHSLLNERIEFSDLGLVIIDEEQKFGVEQKERFKKLRLSVNVLTLSATPIPRTLHMALSGMKDFSVINSPPPGRKPVYVYVAEYSDDLVKGAVIREINRGGQVIYVHNRVEELPEVFEKLKRMFPELEIAVAHGKMSRKTMERIVHEFYRGNIDVLLCTTIIENGVDIPNANTLIVDDAQRYGLSQLYQLRGRVGRSDRRAFAYFLYPKGTPRSALERLKVLKSYTGFGSGLQIALKDMELRGVGDVLGLEQHGNVVSVGLKLYNEILKETITRFKERRIEKKHSVNVEIENPPGRFFIPEDYVQNPVERLRLYRRLASSLDEEDLEEILEEMKDRFGEPPEEVKLLVDYFRLRVRASKLGIKKIRFDHSMVEIFPSRNSPFLNHPRYDRRSGSVVLYTRKDPVEFLMDMLKK
The following text describes a protein:
Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Sequence:
MNAEETRPLDSGGGGEGAETRCQLPRTGAPRRSRAAGTLCPVGRARGAAGGAEGRSGARAAAAAEPGHLRRKEGGSEGGRGRVQTESGERRCRQAGRRASALAQGRGCGSPARSSWAAAGAAPREEGKAEARGTCLGRRGGEGGGRWCARGAVCARSPARGGRWPKRESWGDARVTRRLGGGHRGQPDGAADTQAGGRAVRAPPRPPPHCRWQRVRWVPAAAGAGGRAGEPGRGMGCAPSIHVSQSGVIYCRDSDESNSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASGPPSAARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTSYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAVTHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
The following text describes a protein:
Function:
Essential for ciliogenesis in sensory neurons and spermatocytes. During neuron and spermatocyte ciliogenesis, essential for initiating transition zone (TZ) assembly and is required for the formation of diverse connections between microtubules and between microtubules and the membrane. Regulates TZ assembly by recruiting DZIP1 to the plasma membrane where it promotes early ciliary membrane formation resulting in the initiation of TZ assembly.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme in the olfactory, auditory and spermatocyte system. In sensory neurons, localizes to the transition zone at the tip of the mother centriole. In germ cells, component of the spermatocyte primary cilium and spermatid ciliary cap.
Domain:
The C-terminus orients towards the microtubules and the N-terminus orients towards the membrane in a 9-fold symmetric manner.
Sequence:
MSMDIPETVSLRKFRDFSARQKQELYETLLELAESIDELPKKSLRKTLELTLAVLEYKGEQVQQLQESAAGGLSSDRRLQDENEKLKRMLQKLEDERDGLKSKAKELGEEIRQLELRLQEAAQQAEISDKDSSDPLSELDKQEQLLQNIDSKNKHIKRLLKEIETLQNQNIAQSKTIVLHERELQTIKANLVQLSQDITKVEQERKSLKQKEQQQALEITRLEGNLTFLEVEREKQEVEMRQFLDKYEAKSLGWRQALDDRDKEVERLKKQLEGKSISSGQTNSSNSQSQQEEEHAKLRQLLESREQRIEKLEEKIKSMAEEMVSSTRAMNQLCQEKERAHDPEQPRACCQMIEERLREATARCQQLSEMLEAAEQDNVLKSQQALHAISALEAYKRDEDGLIPALRRCSGLEQKVAARDKQLRAYIQELNSLHEVVQENELLRRKLHIPDDVVIMAKNVHSKQRNKDKQIERLTLKLRTSEELRLQLKLEKSELRRKLLELQQDSPQTLNESLQAPSEVGEVPHSVHLENSPRRGQGDGAASSEMQNRYDEVLAENETLRSGMYEILEKLREYDATSEHITIDSDLLRRLIEALPGGTTTPQRLQGQLLELKAREEALRQLLEQQNYSDSETGELSSVHSLCEVPEIAEEHPVEEDAVLNTATRPSSPTEATMGLRRPTVPDPEEKPTNEALAELSILRKHYDELRLHMSADGSDLMNRNQELHDQMIALELQLEQQRNSYSYMRRDYDQLLTETRKQELRFIDDKASLARQLEHSKSELCEAREELEQVNRRNLYTAEEQQKLEHRNAILSMQLGQAMEQLLGELKPTEICAEYGIIRENYQLDYITAQDFEEQQQELLTWRSKQAELQRETKQLEGLLHVANEQIHSQQRLLNEITDNHINLRHLVADLQSSSDEKLMLAKVQRDLDSVKAECSRLETEREKLQLKADCLQTQLEASELSLKQTQQDFQQERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQRRLEEEQVQQRHRDHTALIDEVTAVVQAKIGLNEESSQQLVKLIKSETQTRLLEQRCEILQAKQEELVRELGELRMSQATDTEHWSTIQALFGEGEPRSQLKVDAETNTDAVAPNLAMRRAVQLIDRESSPIGSPLRKHPHLDTATQTLEAQVEFSETAVQTNGILSQQNQAVQTADAVEDNRRDSRAELQKMQETLQEANQRIEILGKQLEASRSESRESASPQGGVVEKTILSFHTLLLEKDQSIQKYQDLLQTERDQSQQALSKQVAENESLRATVNNLNFNIKTKDAEIQGLKEKLRQKPEVPVERNPSTDSRSSSSSDSSVNELTDEKIEELFESSSVERPPQEELEVPVEAGPENIVTEEPEGEEEKQDTEELKEVPTLHKQIKDLKDKLEYSERSLKTREEEVDILKEKLKLCQEREKSVESTVNPELDQLRIFLDEKDKHIKDLMDTLKNFHDDQQRYIKDTSNFSEDQIAKLAADLNRTEATNKIYHTQMEALRRQLANVTQREKQARDLSQSLRQQLLKRPVVSIKTELNARVKNENQLKRIQQLELDLDEARGQLQRQQTLLEAKRTRSANEVQLWEKQKRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKDKQILESKLGRNGPPSNSSGGNNLKCCRTPSCPNLQHVGVSKFAPSPSESPETYTGPSSECSSPAHHHTQIFDQSQLDLIEALKSRIELQQRKIIAMELEGRGSNALTTELEKLQERCQAIEAQNIRLEARNLQLQLDSDLLRQGDSSDRLQKRIKHLEDYIMALKEEMARNESRRELGSGLKVSTNQGQSAEQTILSLRNLVEKLRSENKFLKDGRRSTESRSSMDSTPAEAARLQQQHAEALEKISALQQELQKRTTKCSQCGGRSKDAANEELKFIKEQLVKKTQLLQKAKVLLTRAAAKEKVLREQLALWKRKCSELQNVPVIDEISE
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID, and the RNA polymerase II associated general transcription factor complex TFIIF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MTTVKRTVRLITDQNVLPGGEAAVLNDQSFPVREWSIKLVCLNPQGEETDASFVDRVTYKLHPTFQNPTRTIRKPPFQIKEQGWGEFEMEIIIYYADKGGEHRFLHYLHFQQEHYHEDIELNINATRPGLLKALTATGEVPGYSDEGEEARKDKRKNESEVGAGKKKAKAKPVDMDKLAEGLQKLQEDDLLQVVQMVNENKTPDMYVRNDIEGGEFHIDLYTLPDNLLLLLYSFCAKRVTM
The following text describes a protein:
Function:
Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway.
Subcellular Localization:
Secreted.
Sequence:
MMGIILAYVGFVFFSVLYVQQGLSSQAKFTEFPRNVTATEGQNVEMSCAFQSGSASVYLEIQWWFLRGPEEMEPGAEGAGAQVELLPDRDPDSDGTKISTVKVQGNDISHKLQISKVRKKDEGLYECRVTDANYGELQEHKAQAYLKVNANSHARRMQAFEASPMWLQDMKPRKNASAAVPSSIHGSANQRTHSTSSPQAVAKMPKQSPQSGARIATSHGLSVLLLVCGFVKGALL
The following text describes a protein:
Function:
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide, phosphatidylcholine, phosphatidylethanolamine, and small amounts of phosphatidylserine from the lumenal to the cytosolic leaflet of the cell membrane and ensures the maintenance of asymmetric distribution of phospholipids. Contributes to substrate binding and specificity of the P4-ATPase catalytic subunit.
Miscellaneous:
MISCELLANEOUS: Present with 2460 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVNFDLGQVGEVFRRKDKGAIVSGDNPEEEEDVDASEFEEDEVKPVRTKNRRPKEDAFTQQRLAAINPVLTPRTVLPLYLLIAVVFVIVGGCILAQNSKVDEVTIYYQDCMTNATSSWSDIPSEHWQFVFHKYKTYNTAPQWRFVDDESDDFTKQRGTCQIRFTTPSDMKNNVYLNYVLEKFAANHRRYVLSFSEDQIRGEDASYETVHDATGINCKPLSKNADGKIYYPCGLIANSMFNDTFPLQLTNVGDTSNNYSLTNKGINWESDKKRYKKTKYNYTQIAPPPYWEKMYPDGYNETNIPDIQDWEEFQNWMRPGAFDKITKLIRINKNDTLPAGEYQLDIGLHWPVLEFNGKKGIYLTHGSHLGGRNPFLGIVYLIGGCICAAMALILLTFWLFGGRKIADASSLSWNMK
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system.
Sequence:
MAYEIPVTQARAELADLINRVVYGGERVVVTRHGKPLVALVSAADLARLEELRESPDAQVIASVAGVHDASAASAPREHHRFGIAAEHRGPDPS
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MKFRGLDLIVFLLAVVSCKANKEITCEENEPFTCNNTDRLNSKGFPKDFIFGVSSAAYQACGRGRGLNIWDGFTHRYPEKGGSDLGNGDTTCESYTMWQKDIDIMDEMNATGYRFSFAWSRIIPKGKVSRGVNKGGLEYYHRLIDGLIAKNITPFVTLYHWDLPQTLQDEYDGFLNRQVIEDFRDFADLCFKEFGGKVKNWLTINQLYSVPTRGYSTGADAPGRCSPKVDARCYGGNSSTEPYIVAHNQLLAHAAVQFQRGRIGPVMITRWFLPFDETNKASIDAAERMKEFFLGWYMEPLTRGRYPDIMRRMVGNRLPNFTEAEARLVAGSYDFLGLNYYATQYVQPTPNPLPVTSERYTAMMDPGTRLTFVNSRGEKTGPLFEELKGENSYYYPKGIYYVMDYFKTKYRNPLIYITENGFSTSGDQTRQEAVADSKRIDYLCSHLCFLRKVIMEKRVNIKGYFAWALGDNYEFGKGFTVRFGLSYVNWTDVSDRNLKDSGKWYQRFINVTTKITAHQDFLRSGLSFENKMKTLTDA
The following text describes a protein:
Function:
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MANMEALSKRLDTYYVAIKKLILKYQSPSIGLFPLDTNIKGPDSLCGHVRDNIYCAAAIWSLSLAYRKLDDDRGRTYELQQSAVKCMRGILFCYLRQTDRMEKFKRTQSWQDSLYSTYHIVTGDPIGDIAGQLEIDAVALYMLYLVQMIGSGLQVVYTSDEVDLIQNLVYYIERAYRTPDYGMHHTDNKKDANRELRASSIGMVLAALHAINGFNVFGPAGTSSSVIYVDPDAYHRNNTIFHTLLPRESSTRDTDAALLASVGYPAFAVTDEELQLKTKAVILNKLMGSYGLKRFVNDSYHVPVVDCIDDGYTLTQRSKNLECEWPIYLIFLSLDAIFNGDEEKSQKYRDRLKDLIYMSDGTEIVPEFYYVPKHYVHSERVNPKSQTKKICGSRYPGSLFLQGQSLYYIQQLLEYLSNLSGIVNEIVDELITVDDIDVIGRHSPSSLWRQYSSKGGGSFKRFEQLGYNKKLGLNGRPKRPMGPLGTSKVYRLHGIPIISYPLMLDQTDFYMSLDSSVFINNLKNGLKFIHDNWNMTGRPTVCVFLRDFNVRRSHFREIFDLIYTLKTGECNGVRIRLGKLQETDNLLKKMTILNILLKDHGPGHYFIDGNILDCVNSVYSTACSVLAWSAIRYGASLLNKVVDSLAPSITTMLVKGKQVTLGIFGHEEVVVSSPLTPAEIKLILYSKCVSYNVREAVLQQECVESLSPSMIRKLLIQLLSSEFHELPEVKSEKRWLYHRILVGAINRVPKNFYENVWNVLYKAPDGICVSGKVLPRSPTIKEMTCRGMGFALRVEEMLSGISKPQYRQIAVELLTVIATIAERNPELHFQEVINLNKIVMNAIELFIASNPNYEGLTLEEQEDHFFSSSPCDKNSTTTFLARAVVNQLLEGCITVTEQSPCSIT
The following text describes a protein:
Function:
May play a role in the cell adhesion to the extracellular matrix.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted.
Sequence:
MLALAKILLISTLFYSLLSGSHGKENQDINTTQNIAEVFKTMENKPISLESEANLNSDKENITTSNLKASHSPPLNLPNNSHGITDFSSNSSAEHSLGSLKPTSTISTSPPLIHSFVSKVPWNAPIADEDLLPISAHPNATPALSSENFTWSLVNDTVKTPDNSSITVSILSSEPTSPSVTPLIVEPSGWLTTNSDSFTGFTPYQEKTTLQPTLKFTNNSKLFPNTSDPQKENRNTGIVFGAILGAILGVSLLTLVGYLLCGKRKTDSFSHRRLYDDRNEPVLRLDNAPEPYDVSFGNSSYYNPTLNDSAMPESEENARDGIPMDDIPPLRTSV
The following text describes a protein:
Function:
May be involved in arbuscular mycorrhizal (AM) symbiosis with AM fungi.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MALSNLKSNRTLSSSLITIFIISLFLQYHNIKSQSSWQSRQVPRSETVAFSITEFEKENPDIFLRGDTSISDGILRLTKTDQSGKPLPNTVGRATYLTPIHIWDKTSGELADFSTSFSFIVNTNDSDLHGDGFAFYLGPLHFDVPKNSSGGYLGLFDPENAFPPSKTPILAIEFDGFTNEWDPPSSFQSPHIGIDVGSIVSLEYAQWPINFVPRNALGEANINYNSESKRLSVFVAYPGTQWNSTRVSVVVDLRSVLPEWVRIGFSATTGELVETHDIINWSFESAL