lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Putative transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity-inducible transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSSIEPKVMMVGANKKQRTVQASSRKGCMRGKGGPDNASCTYKGVRQRTWGKWVAEIREPNRGARLWLGTFDTSREAALAYDSAARKLYGPEAHLNLPESLRSYPKTASSPASQTTPSSNTGGKSSSDSESPCSSNEMSSCGRVTEEISWEHINVDLPVMDDSSIWEEATMSLGFPWVHEGDNDISRFDTCISGGYSNWDSFHSPL
The following text describes a protein:
Function:
Absolutely required for the growth of E.coli in a high-phosphate medium containing G-1-P as the sole carbon source.
Subcellular Localization:
Periplasm.
Sequence:
MNKTLIAAAVAGIVLLASNAQAQTVPEGYQLQQVLMMSRHNLRAPLANNGSVLEQSTPNKWPEWDVPGGQLTTKGGVLEVYMGHYMREWLAEQGMVKSGECPPPYTVYAYANSLQRTVATAQFFITGAFPGCDIPVHHQEKMGTMDPTFNPVITDDSAAFSEQAVAAMEKELSKLQLTDSYQLLEKIVNYKDSPACKEKQQCSLVDGKNTFSAKYQQEPGVSGPLKVGNSLVDAFTLQYYEGFPMDQVAWGEIKSDQQWKVLSKLKNGYQDSLFTSPEVARNVAKPLVSYIDKALVTDRTSAPKITVLVGHDSNIASLLTALDFKPYQLHDQNERTPIGGKIVFQRWHDSKANRDLMKIEYVYQSAEQLRNADALTLQAPAQRVTLELSGCPIDADGFCPMDKFDSVLNEAVK
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MVRGAQVAGGRGTPTLQTSLAPSLRAVAPLAPLLAYPSPTARLGAACGALPASSSSSSQSCTALSCLLHSPFLRLHSHSHSPSATAAPLQRHTAAAPSTSSSARSGRALHGRAATALTAVNASGAGPAASASSAAPAAIVLGIESSCDDTGVAVVTSDGRVLGEAIATQADIHSQWGGVVPNLARDAHAAAIDAVVERALAAAGLRPEQLSAVAVTVGPGLGLCLRVGAAKAREIARAHRLPLVSVHHMEAHALVARLPAAAAAAAPPAVRLAAVAAPTSPSAATGSTASWDTRMELRPEAPDVVGSGSDASSSTSLASSSSVPASSTAAESAAAAYASGATSGAADGASSSSGAAPQAGATATERGPTASTSGRGGGGGAAAAASGDRELDAAAVLADVSAAAASLPFPFLCLLVSGGHNLLVLVRGVGSYVQLGTTMDDALGEAYDKVARLLALEMRPHGGAALEALARQGDATAFKFAVPMRKYGTCDFSFAGLKTSARLAIEQTLSPAAVEGLSPEQVNKAKADIAASFQSVAVTHLLEKSRRGVAWAREMEPGLAHLVVAGGVACNQVVRAALNQLADKEGLQLVLPPPRWCTDNGVMTAWAGIERLARGWAEPPPPPLPLPSPAEREAAAVAAAAAAEAAAAYPASLASVGEEEVAGVSGSGAAAAAAATGGAAGGGEEWIELKPRWPLTSELHPRSAAAQADQRRSIKKVRMAVPLSDLEPPSPPPGLAAGAAAAGAGAAAAGAAR
The following text describes a protein:
Function:
Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane.
Subcellular Localization:
Membrane; Peripheral membrane protein. Mitochondrion.
Sequence:
MLRSTLRRLTKPNVVVLGTGWAGSYAAHHVDPNLCNIHVISTRNHMVFTPLLPQTTTGTLEFRSVCEPITNIQPALAKPPHRFLRSVIYDVDFDEKQVKCVGVGVVGGSENVPVNTFSVPYDYLIMAYGARPNTFNIPGVEDKAFFLREVNEARGIRKRLVQNIMTANLPTTSIAEAKRLLHTVVVGGGPTGIEFAANLAEFFREDIKNVNTSLLPYCKVTVLEAGEVLGSFDNALRRYGQLRLNQLGVEIRKTAVVGVTDEEVFTKSGEVLPTGLVVWSTGVGSGPVTKALKCDKTNRGRISIDDHLRVLRDGKPIPNVFAAGDCAANNERPLPTLAAVASRQGRYIGKETNNLLKGKQMSKPFVYRSLGSMASIGNRTAIVSLGDKFKFDLNGCAALWVWKSAYLTILGSIRSKLYVIVNWAGSQIFGRDITYIGDLAEDRMYSALAVEEVSKEMNRKKTPEMPHGVNPESSYTSAVEKEGAHKGFLPRKLAESTPLAPHGQAIEGSQVAHAAAAATSAEPAKKM
The following text describes a protein:
Function:
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
The following text describes a protein:
Function:
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MNYSKYDEAVRILFSTNQNDASQLQEANDYLRENEYSPQSFQWTIDKLQTTTEKTIVKHAEILLTHWCANAWEQIPADLIDQLRQALFLSKFMSNNDIDQSLLNIIGTSQVSFVLKMYPQYWPSFWSDFLEVADGMVYTFLLALKDYTKALNLRDQLQYRDFKNAMRQDGSDKLLADYIISRLPSYDKKCFEIYIYLISWINFNFIWTTDTLEVLNNTLSSPDTITYGIRCLSALIERGMPDEEKTSLIQSLQIPERISAIIETDNEEIITEIASLLRSISKSTKHPEIIQEFVGFALTIFEMNTYDSSLKILDFFEKYLKINSENSVLIFELCYAKLALYFENDSVIDDILPIKISEIISKIKKLSPEINENFVKKISSSDTLQDTCACLLICSTVYKDNSCNEISISAILTFSEVLDFSVPFEYDQQLSAVILYSSFLSYCANLFEGKTIFEFFEKLVYFSECDVSSALINLSKNKNIHEFITNDFVVTLASTRNESLLKCAAIFIEYLKDGQDEVLGTIIGLLQGFLMEDNENLFDNAKKVLLFIKSVNSESIEGYSDYVYPLLTEYQQCFSQDDIIFAEYIETLSIAIGNDSLKILLSLISSINGVYSLISICNSLKRCFTKDNSEWVTSVFETIMDGVIEEFNEEIDWNCENEEKTISINLLISFISFCSTVFERIGYNERLFVFISNTFVDRCDQPLILSCLCDFCAVVANNDPKLASGFMIPSISFLLYSGFDPVLNLWKNVVRSAAEFHRILVTSEESSIIVNSFQELGFDENYATNYIEIFKLPRQMHGKQAIKLFSDMKHLINS
The following text describes a protein:
Function:
Catalyzes the conversion of chorismate into prephenate via a Claisen rearrangement.
Sequence:
MIEKLAEIRKKIDEIDNKILKLIAERNSLAKDVAEIKNQLGIPINDPEREKYIYDRIRKLCKEHNVDENIGIKIFQILIEHNKALQKQYLEETQNKNKK
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSAKQLGDLKPLFIEWLKDEIDACGPRQEKMAMVYFRARESLKRFDQPITETAKVLKVKGIGNSIKNKLASKLAQYCQDNNIPLEDAAAPSHVVGISVTRVRTATQEKDDQSPKRKKRKYVPRKRSGAYAILLGALELGCPSRGLTKEEIIDAAAKYCDVSFVSNPLTREFYSAWTAIKVLIDHDLMLEQGRPRRYIVTEAGEQMAETLKHADSVIFPEDCPYQRRQQAPESTAEDHTELSASLSELVRQEHLPQNHSGMCFSFEPPSSAPSDYLDPGQKSANVASSPHRLRPPIGPSIDIVKARWNGTSYELWKPGSYDIELYIDHREVRAKSERDFFVNALLTRGVTVEGKALALGDMVWVARHRDSRSTCVLNFMLERKRLDDLAMSIRDNRFMEQKNRLKKTGCKHIFYLVEETSGTNVAGMEGAIKTSIWMTYVYSGFHVKRTRNADDTVEWLHDMTCTVQRYYCSKSLLVLRPREIANQEDYGSLLSAFRLQFERNNTSLECCHAFDCYQEVLGKTGLMTVKELYIRTLMLNRGVSLEKALAIQSKFPTLRSLMTAFRNCKSEEDGRRMLYLALLDQPASRRVGKALAATLWDTFGRR
The following text describes a protein:
Function:
Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity).
Subcellular Localization:
Secreted. Note=It is transported to target tissues via hemolymph.
Sequence:
MIIKALAIVSLCLASIQASKVGAPQLPKKHLVCYYDSASFVKEGLGKLVIDELEPALQFCDYLVYGYAGIERDSHKAVSLNQQLDLDLGKGLYRTVTRLKRKYPNVKILLSVGGDKDIELDKDAKELPNKYLELLESPTGRTRFVNTVYSLVKTYGFDGLDVAWQFPKNKPKKVHSGIGSLWKGFKKVFSGDSIVDEKSEEHKEQFTALLRDVKNAFRPDNLLLSTTVLPNVNSSLFYDIPAVVNYLDFVNLGTFDFFTPQRNPEVADYAAPIYELSERNPEFNVAAQVKYWLRNNCPASKINVGVATYGRPWKLTDDSGDTGVPPVKDVKDEAPVGGNTQVPGIYSWPEVCALLPNQNNAYLKGANAPLIKVQDPAKRFGSYAYRAADKKGDNGIWVSFEDPDTAADKAGYVRTENLGGVALFDLSYDDFRGLCTNEKYPILRAIKYRLTN
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MVEIKNLSLDYGEEHILDDISLSIAEGECVLFTGKSGNGKSSLINSINGLAVRYDNAKTKGEIIIDGKNIKNLELYQISMLVSTVFQNPKTYFFNVNTTLELLFYLENIGLAREEMDRRLKDMLKIFPIKNLLNRNIFNLSGGEKQILCIAASYIAGTKIIVMDEPSSNLDIKSISVLAKMLKILKEKGISIIVAEHRIYYLMDIVDRVFLIDKGKLKKTYTRSEFLKLDKNELNALSLRDKELSKLKVPYLKEGGEYQIKNLSYKFTDDECLSLKDISFKLGKIYGIIGSNGRGKSTLLRCLIGLEKKSKEEIYFKGEKLSKKERLKNSSLVMQDVNHQLFTDEVFNELRLGVKNFDEEKAKIILKDLGLDEFIERHPMSLSGGQKQRLAIASVMCKNSPFIFFDEPSSGMDYSNMIKISELINKYKTMDKIIFIVSHDIEFLNEVADEIFEL
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MMSSGTGGSSKRSKTKSCNSGSAPKCKRNREQKALGVAWGANSFSAFSFSSTKKRRNAPFSDFASYMESKERKLRVQFDADASNSSNRDSDVNKCIFHGISIFVDGFTIPSSQELRGFMLKHGGRFENYFSRHRVTHIICNNLPDSKLKNLRAFSRGLPIVKPAWLLDCIAANELLNWVPYQLVQLGKDIPKQQKLPTYFSPKSVSTSKSFETPTKSHLKIYTDGMSTSSEGSIDKDSDSLTGGSNHEKVNDGCLDNKKKREPLVLTAEDAEKSRWSHVKGSMLVANILEATSTVEEADQSECSHVKGSTLDANKFEGTADVLIEDSIHEPAKIYDARNTEVNSSNLEDTCSEKVVSESSSHTKSITGGNICSDSKKMKDHNSTRFSGQWNSTLRDVNFVENYFKNSRLHFIGTWRNRYRKRFLNLLHGDHHGNSAVDALNCTQSPTIIHIDMDCFFVSVITRNHRDLCESPAAVCHSDNLKGTAEISSANYPARDYGVKAGMFVRDAKALCPHLQIFPYDFESYEVVADQFYEILHKHCNKVQAVSCDEAFLDVSDLAHKNPEHIASIIRQEIFDTTGCTASAGIAGNFLMARLSTRKAKPNGQYFISSAKVDEHLIGLPVKELPGVGRALEEKLTNRNIRTCDHLRAIPKEVLQNEFGVKIGELLWHYCRGVDNRSVQVVQENKSVGAEVNWGVRFNELKDSQEFLVNLCKEVSLRLQGLGLQGRTITLKVKKKKKGAPDPAKYMGCGDCKNLSHSMTIHAATDNVDVLLRISRQLFSSLNLDVREVRGLGLMVSRLETAEFMQQGSERNGLRAWLASASETNKESCNIVHSANDNVSKGALSVDGYGSSSSVQHETQFAQSFAQASTKVMSSSEKGKCKEMVSPLVPMSQLDLEVLESLPHDIHFEINQMYKGKLTDLMENCKYIRNDVPPVKSIPEAIKENPSASCSKSLPDGPSKAMRHCHSDLSDSTSQFKISVKHSIGSPVTDHVTLPAKHKVEIENLERIEAASISPTGDINMHATIMKGNMADVMPASTRKVARSVIRDLPDNLHHDILDSLPVHFQKSGDSILVCENVCPGEIFKSDTTESSRGRMGSVVNIHMWKGNPPSWISKFKHSNFLILNLLAEYYSMFGEPGLLSNTLQRLLSAQALDLDAGNNEWDKALSSCCELLTQYIELKIKSDMEEIFICFRLLKSSYYAASTSPSCASFLCWI
The following text describes a protein:
Function:
Negatively regulates embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKl and SHPTP2 to the tyrosine phosphorylated form (By similarity). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (By similarity). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts. Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). In conjunction with NKX2-5, positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity).
Subcellular Localization:
Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Basolateral cell membrane.
Domain:
Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif (By similarity). The SH2-binding sites putatively bind CRKL SH2 domains (By similarity). The HLH motif confers specific interaction with the HLH protein ID2 (By similarity). It is absolutely required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization with BCAR1/p130cas (By similarity).
Sequence:
MWARNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPIQETPSGQDQPTSGLMHQTFGQQKLYQVPNPHSAPRDTIYQVPPSYQHQGIYQVPTSHGIQEQDVYQVPPSVQRSIGAANGPHLSKKVVTPVRTGQGYVYEYPSRHQKDIYDIPPSHTTQGVYDIPPSSVKVPVFSLPVGEIKPQGVYDIPPTKGLYAIPPSACRDEAGLREKEYDFPPPMRQAGRLDVRPEGVYDIPPTSTKPTGKDLHIKYNCDAPGAAELATRRHQSVLLNHAPSQLGQSPGAQNDAYDVPRGVQFLEPPAETSEKANPEERDGVYDVPLHNPPDAKGSQDVVDGMNRLSFSSTGSTRSNMSTSSTTSKESSVSASPSQDKRLLLDPDTAIERLHRLQQTLEVGVSSLMALVTTDWRCYGYMDRHINEIRTSVDKVELFVRDYLHFARGAVANASCLPELTLHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAVNKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPGPGSSHVKSGSENIMNSTEYPHAASQMPLLHPGDHKAQGLNKPLPPSLGKDQPPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIIKQNKLQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSSVGAQDRQLLCFYYDQCETHYISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDICHKVMNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
The following text describes a protein:
Function:
Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.
Sequence:
MFHKFISTLTNKKITQTIMGTINKENIKPAMLLSAFGDACGYKNGIWEFEKSPSRIYEHYEYLGGYKNLKINKKDWRLSDDTIMHIATAIAITRPTNTDNESICKELAKAYIHSMEDMAGRAPGIQTINSVSLMTQTGMRSKVYQWNEIDFSDRAGGCGGSMRSMCIGFKYWSDEQLDTLIELSIESGRITHNNPVGFLGALVSALFASYAIRSIPPKTWPLKLMTEVMPKAREYLEKTSNSSNRNIENYEKGWNYFWNSWKSYLKLRQIPSNPDELKAANDKGIDYPVFPKDYSDYKVRENFYHSISFSGWGGSSGHDSCIIAYDALLGSADNWEEMIKRSVLHGGDNDSTGAIGCCWWGALYGFNGVPECNYEKIEYKSIIEGLAKEISN
The following text describes a protein:
Function:
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MREPIVAIATPYGESAIGIVRLSGKGVLDLVKKFFKTKREIKPRYAHFGVLYDDKGEELDEGVLIYYKAPHSYTGEDMVELNLHGNPRILKRALELFVNAGARLAEPGEFTKRAFLNGKLDLTQAEAVAELISAKTELARKVALKQLHGELSKHIRPLRETLLELLAYVEADIEFAEEDIPTLTKEQVIQMVDKVIEGINELLKTAKTGKFIREGVKLAIVGRPNVGKSSLFNALLKEERAIVTDIAGTTRDFIEETLQIKGVPVRLVDTAGIRETKDLVERIGVERSKQKVKEADLILFVIDASQEITEEDLRIYEEIKEKDHIVVANKVDLGIRANLEKFKGEKIVKVSALKGTGLEELSEEILKKVGANLEESVNIYISVRHETLLKKAKEVLERFKEEFREKDISPEIAMLDLREASDYLGEILGEITTEDLLGKIFSTFCIGK
The following text describes a protein:
Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Zona pellucida.
Sequence:
MRWFAGTWVLVVALGICTLVSCVQGFWDGLRCGPTNMQFSVPSQVPDAGFALSAVDHTGKPHYLGNDTACGTLVGQKPDGSLVVDATYDGCYVREENGDHVMTVSFEEVINGRVNYHKQELKCPVMEAKDVPSPDACSAIQRVDRLSCAKAPVSQDLCQGLGCCYTPSDPTMPCYYGNKLTAQCTTDNNMLIAISKDVTKPSLTLNSISVVGVDQTSCPSLSVSKTNAFIMFQFPLSCGATKRIDSNLITYESTVVSARDIRTWGGSSITRDSIMKLTVRCVYGRSGIAPLLKVEVHTLPPPPPISTPGPLALEMRIARDMQYTSYYADGDYPVVKILRDPVYLEVRVLRRLDPNLVLVLNSCWATPSTDPMAQPQWPVLSSRCPFPGDNYATQMIPVGAATQAVPFPSHYQRFSISTFTFVDGTTQLPLGGMVYFHCSASVCVPSAADPCRVVCNTRKRRMAEESPAEYPMGTTVTSDGPVDFIDEEEKLTEREGVISFGHPALHWARGAAAIGGVVAVTITIIGLWIHYRNRSPKTHDVNA
The following text describes a protein:
Function:
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Domain:
The TBM domain mediates interaction with TERF1.
Sequence:
MAPPPGVGPASLRFAAAASWLVVRRRRVEHFPKVVEFLQSLRAAAPGLVCYRHHERLCMSLKAKVVVELILQARPWDQVLNALKHHFPAESRTTKEDRKLLEARENFCLLVKHLSEDPPSSLQELEQDYGESFLVAMEKLLFEYLCQLEKALPPVRAQELQDALSWSQPGSFITSSVALHQYGMDMGWTFPESSTSGSGNLIEPMEESPHQQTRPAFHSPLPKAKLGPHQPASLEHPEHLAGHRFNLAPLGKRKSRSHWTSAKACHKERPTVMLLPFRNMGLPAQDLSNPKSREEPGAASAASVGTEPVCTEEAKTPSRPLGKRALEETPPDSPAASRRTV
The following text describes a protein:
Function:
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Postsynaptic density.
Sequence:
MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDAGPMKTNSTNNHKDKNLRQRNTN
The following text describes a protein:
Function:
Transcription activator that binds calmodulin in a calcium-dependent manner in vitro. Binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3' (By similarity). Regulates transcriptional activity in response to calcium signals (Probable).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Incomplete sequence.
Subcellular Localization:
Nucleus.
Sequence:
MDGDGLGRLIGSEIHGFHTLQDLDVQTMLEEAKSRWLRPNEIHAILCGRIILFDRKMLRNFRKDGHNWKKKKDGRTVKEAHEHLKVGNEERIHVYYAHGEDNTTFVRRCYWLLDKARENIVLVHYRDTQEAATTSGDSISSPISVSEQTFPNRVAAEDIDTVVRNHDISLHDINTLDWDELLVPTDLNNQSAPTVDNLSYFTEPLQNAANGTAEHGNATVADGSLDALLNDGPQSRESFGRWMNSFISESNGSLEDPSFEPMVMPRQDPLAPQAVFHSHSNIPEQVFNITDVSPAWAYSSEKTKILVTGFLHDSYQHLERSNLYCVCGDFCVPAEYLQAGVYRCIIPPHSPGMVNLYLSADGHKPISQCFRFEHRAVPVLDKTVPEDNQDSKWEEFEFQVRLSHLLFTSSNKLNVLSSKISPHNLRDAKKLASKTNHLLNSWAYLVKSIQGNKVSFDQAKDHLFELSLKNRLKEWLMEKVLEGRNTLDYDSKGLGVIHLCASLGYTWSVQLFSLSGLSLNFRDKQGWTALHWAAYYGREKMVAALLSAGARPNLVTDSTKDNLGGCMAADLAQQNGYDGLAAYLAEKCLVAQFRDMKIAGNITGDLEACKAEMLNQGTLPEDEQSLKDALAAYRTAAEAAARIQGAFREKALKAARSSVIQFANKEEEAKSIIAAMKIQNAFRKYDTRRKIEAAYRIQCRFQTWKIRREYLNMRRQAIRIQAAFRGLQARRQYKKILWSVGVLEKAVLRWRQKRKGFRGLQVAAEEDSPGEAQEDFYKTSQRQAEERLERSVVRVQAMFRSKKAQQDYRRMKLTHEEAQVNHLTFLNLSFGKKNSNRR
The following text describes a protein:
Function:
Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.
Sequence:
MQDLYPSRQRADAEMRPRLDPVVHSEWTNDAPISARQAAAFDRDGYIVLEDIFSADEVAFLQKAAGNLLADPAALDADTIVTEPQSNEIRSIFEIHAQSPVMARLAADARLADVARFLLGDEVYIHQSRLNYKPGFKGREFYWHSDFETWHVEDGMPRMRALSMSVLLAENTPHNGPLMVIPGSHRTYLTCVGETPDDHYLSSLKKQEYGVPDEESLAELAHRHGIVAPTGKPGTVILFDCNLMHGSNGNITPFPRANAFLVYNAVSNRLEKPFGVEKPRPWFLARRGEPAALRVERGPLVETVPA
The following text describes a protein:
Function:
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MFISTIGGSKMLDGFKQFLLRGNVVDLAVGVVIGAAFGKIVETLVSGFITPLIAAIGGQPDFSGLYFTINNSKFMYGQFINAIISFLIIAAVVYFLIVLPLNALIARAHKEPSPDPTTKKCPECTSEIAIDARRCPFCTSVLVGSPTK
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Essential for ecdysteroid biosynthesis. May be involved in detoxification.
Miscellaneous:
MISCELLANEOUS: Member of the Halloween gene group.
Sequence:
MSQPKPILYYDERSPPVRSCLMLIKLLDIDVELRFVNLFKGEQFQKDFLALNPQHSVPTLVHGDLVLTDSHAILIHLAEKFDEGGSLWPQEHAERMKVLNLLLFECSFLFRRDSDFMSATVRQGFANVDVAHHERKLTEAYIIMERYLENSDFMAGPQLTLADLSIVTTLSTVNLMFPLSQFPRLRRWFTAMQQLDAYEANCSGLEKLRQTMESVGSFQFPSSSAVVTEKVE
The following text describes a protein:
Function:
Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
Miscellaneous:
MISCELLANEOUS: Unlike the carbohydrate-specific transporters of the PTS, the complex DhaKML has no transport activity.
Domain:
The EIIA type-4 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB type-4 domain.
Sequence:
MTYGIVIVSHSPEIASGLKKLIREVAKNISLTAIGGLENGEIGTSFDRVMNAIEENEADNLLTFFDLGSARMNLDLVSEMTDKELTIFNVPLIEGAYTASALLEAGATFEAIKEQLEKMLIEK
The following text describes a protein:
Function:
Internal protein I is one of four proteins in a complex that functions in bacteriophage head maturation.
Sequence:
MKTFKEFTSTTTPVSTITEATLTSEVIKANKGREGKPMISLVDGEEIKGTVYLGDGWSAKKDGATIVISPAEETALFKAKHISAAHLKIIAKNLL
The following text describes a protein:
Function:
Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. May participate in intracellular sorting of GAP1 out of the endosome (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MGKKKFVNKNKAQTFHLVHRSQRDPQYHDENATERVLVSAETLNKTARRLNRQTLDEEYGSTIRPNEGEAANYGIYFDDTEYDYMQHLRNIGNEDATWVEAPATRKTQDKQKKQQIQLRDQPSILPQEVLPSEVELERTYQDQQSVPDAISGFQPDMDPRLREVLEQLEHSDINDEETSDFDEEFEKLVASGKADESEFYAQPFVEEGEKDYDEAAAAKAGKSEWEIEFEKFKLEQKKQPDVASSDGDFSDEPESEERDEVPELVSSSKSKSKTKRKARTALSSVSMSSSALFRNEGLTLLDDRFDKVEEEYTPIKDERELIDPDQKDVFDLVNDNQFNDIMDEFLVSYGPTLGRKKAPSRMSNSKKKSSLEELDNVRKMLGRARI
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MPSAVAANGALISNEEQACGAEVEGQAKGRAMSMVCEECCEQESKYRCPGCGFRTCGVKCVKSHKERTKCDGKRKRTEFVNINDYNDNWLISDYNLLEETLRLADSAKRLRAPFTSGVRNEVPPQVKALQKQAKARSTTLLLLAHGMTKRAVNTSYFDKRNKRIFWRVEWVFEGTDVRLVDSRVDENSTLESVLAKHLAHDAENVTVRYLLRSFRWKPLHELVLLLPKEPCSAAEKEYFELTLGNPLKDQLADKSIVEYPTIHVLLPGSLGNFASAKISKAVPPKVLVPDEIVGDRIQDPQELEGVPFKEEDFEEGEYLEDGEIIS
The following text describes a protein:
Function:
May transport inorganic phosphate (Pi).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVKFQKQLAGQLVPEWKEGYCDYKQLKRDVKRIKEYHQLVHVSMSDENVSKNSVQMLKSFGSPFVAFSDRLVNNPLFLRGKVENITVHIHQIRHCGSDDGRFGTELYETELLDSALTPTDLALKFFKKLDFELNRVNQFYKLKEEEHHLRAHSLQLQMAALLDLRRRQDSAIAGDGCDWEKILSSASSDEHKPEIFMNALKIQLRREAAVNKEQVQLSEKLLRTAFAEFYRGLGHLKSYSAMNIMAFSKILKKYDKVTGWNASLTYLRVVEDSYFASSDKVLKLMDGVENIFTLHLTRKNYREAMIYLRPFQKKTFRSIAYFQGVFTGCSVAFLSVLAATVMIPSPLESQVDTKGESVEKKSNVLFPLSSTVGLVLLHLYMYAWDMYLWRRARINYALIFRWEPGTELQYQEVLLLSTGFTTLWMLGMIVVKMYPCLPRVDLIPLFTLVVLIAILFLPLNICFRSTRMAFLRCMVHVVSSPFYKVVLADFFLADQLTSQVTVLKNIQYLACYYMGGHFQSHNGASCTEGLTVRCLQYVAILPYWWRLMQCARRWKDEHDFQQVLNGAKYLSALISTAMKVAYRQSSGVWLFAYVASSFISSFFGIYWDLVKDWGLMQSKSVNPWLRDHLLLKHKFAYYISIVVNISLRMAWLTAVLVEQTFDLDDSTIDAVLAVLEVIRRGHWNFYRLEYEHLHKFADMGALQRIPLPFQNLEDP