lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Sequence:
MRPVANAPFELRGKSVYVAGHRGMVGAALVRRLAREEVRLVTVDRREVDLCNQAAVFDWFARTRPQVIFLAAAKVGGIVANNTLRAEFIYDNIAIAANVIQAAHQNGAEKLMFLGSSCIYPKLAPQPLREDSVLTGPLEPTNEPYAIAKIAGIKMAEAYRSQYGSDFISVMPTNLYGPGDNYHPELSHVVAALIRRFHEAKVSGAKRVIVWGTGTPRREFLYVDDMADACVHLMKTYSSPEPVNIGTGEDITIADLALMVAAAVGFRGEISLDTSRPDGTPRKLLDVSRLSRLGWRATTSLTEGIQLAYRVFCAERDGRLQSDLLVLDKAACITG
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MKMLNTPLLTNYKNSLEPTQFCLVCGDEKAGRHYGTVACNGCKGFFRRSVWDHRTYSCTMGNNCDVSQVYRNRCRACRLQKCYSVGMDEKSVQSERHPAKIGEIEPAKMPKHPKAAKMNYRTKRASIQNTLPSTPSPSSSPSTTPDMDNSSKTVMELREIQRRVENTCIPEYEDMVQCFDNYCTVDVPLRTAMVDPGKVAKRNKLEWSKAHRLANTRDITVTWCRTFLWFHDYMNSFPDLCNLNIADRTTLLKLRFAPVSWLLYAWQSYRLGIDGVTFTNDAWYPNDADLQEKVEKPVSDYYQKCTSTMMNELVNKMKLIEMTEEEYSMMLAIILFRRDYRLTHEANQLIENFGNMYLSALIEYLSNHMPCTFDEAIFTGGSLIPERYDSLERLATFIGFITSCQTTTSPSSQSSIWLTSSDYPLRSIQHFIHQPATSNNRLLFIEQTSRTFQNLLI
The following text describes a protein:
Function:
Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity.
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region.
Sequence:
MIVPDTEGLLIYSYGLMYGSYCMACQMLIPHFQCIPGIFPNFRISTELIKTMTDKLEQPNNNVPQQPWGPFPPAFGGRPSGEQTDGNPGEFDNDAAHQQTAPFMTHFFPRIGLQFPDFTEYQRFNGFQRNAFFPNPFGSQFTGQAFAQSFPLHNSMTTMDGFNLTHAPHPFSTNTNSTKPKDIENTVQSTIKHSSENIQDKPPVLSVEYPVKYDSELKFDANVDFTAVPKQESSDDSTLKNLKKSDQQLQQPQQFTFPPPLLAEKSFEQPRMREDVLPFHPQFYPAPLDMGTNFKQEMRTPPIDGHIDYRKFDASGKRMEFQPPGALHDCQVCLSTHANGLHFGARTCAACAAFFRRTISDDKRYVCKRNQRCNNASRDGTGYRKICRSCRMKRCLEIGMLPENVQHKRNRRDSGSPPRKTPFDTFFNGFYPSFQPSGSAAQPITVSSSESPRHTTN
The following text describes a protein:
Function:
Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
Sequence:
MTESFAQLFEEFLNETQFQQGTIVKGTVVAIENGYVLVDAGLKSESAIPAEQFKNAAGELEVQVGSQVDVALDAVEDGFGETQLSREKAKRHEAWIVLEKAYEEAATVIGIINGKVKGGFTVELNGIRAFLPGSLVDVRPIRDTAHLENKELEFKVIKLDQKRNNVVVSRRAVIESESSVERDELLETLQEGTEVKGIVKNLTDYGAFVDLGGVDGLLHITDMAWKRVKHPSEIVNVGDEILVKVLKFDRDRTRVSLGLKQLGEDPWVAIAKRYPEGHKLSGRVTNLTDYGCFVEIEEGVEGLVHVSEMDWTNKNIHPSKVVNVGDEVEVMVLDIDEERRRISLGLKQCKANPWQSFAEAQAKGDKVTGKIKSITDFGIFIGLEGGIDGLVHLSDISWNVPGEEAVREFKKGDEISAVVLAVDAERERISLGIKQMENDPFNAYVSDNKKGALVNGTVTAVDAKGATIELEDGVEGYIRASEVSRDRIEDASLILNVGDKVEAKFTGVDRKNRVINLSIKAKDEAEEQEVMATLNKQDEAAFGNAMADAFKAAKGE
The following text describes a protein:
Function:
Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MLMPMKNWIAIYELLLKETVMLPRRTSTCQSTPSWQERMCPIFMSPRPRGLSSHNATEETVCWRHFYWCLTNKGCQYLRDYHHLPPGVVCATLHHSHPETGRPGRKGWRASGPQDSPETSMDRLPSQQRNSTSEADVVVNLASQLRLEGIVLC
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron.
Subcellular Localization:
Autolysosome.
Sequence:
MARPLALIAGLGVGLRRSSQVRRPAGSWPLRTQSRVGDEREDSSHELPGPGPLLPPTPHFVLSSLLPTNLELLDSSELFHPGGDGRQPSGQLASVSLLHLPLSSFVSTMRMWLWRGVGCFFCKLAKKKPEGSQRLLKTQNQHGSCPFFQDMQKLSRTKWGKTLDPVEAAMILKRNFNQALLDQHALDTAGTDPHLCDFLENHFLDGEVKLIKKMGNHLPYLCRLAGAQAGPKEYLFERLTLKQNKESLEPRGL
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MQQKKKDSPLVQLSKTMSYFLRHGALKEGIPIRQDGFVLVQDLLKQPSIVKLKADLQSIRNVVDNNDKKRFELKEIDGQLYIRCVQGHTIEINEEELLQKIVDPQQFPVIVHGTYFQAWDLIKNTGLNKMARQHIHFAVGLPGDDAVISGMRNTCEVIIEVDMEKAMKAGIQFYVSKNGVVLSSGVDGVIAPQFFKRVTNRKGQDINFQQQQM
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MRKMLAAVSRVLSGVSQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLRYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSIS
The following text describes a protein:
Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli. Plays a role in pollen development and germination and tube growth.
Miscellaneous:
MISCELLANEOUS: The enzyme has a slight preference for phosphatidylethanolamine over phosphatidylcholine.
Subcellular Localization:
Secreted. Endoplasmic reticulum.
Sequence:
MIRGGALTHVALGLTVFLLLAVVHSQEKCSKTCIAQKCNVLGIRYGKYCGIGYFGCPGEPPCDDLDDCCMTHDNCVDLKGMTYVDCHKQFQRCVNELKQSIQESNNQKVGFSKECPYSTVIPTVYRGMNYGIFFSGIGNIIIPKKPASAGPVVEVDLARSKADTKDGLGTNQGPQTKDGSKVSVPMNPSPS
The following text describes a protein:
Function:
Involved in meiotic chromosome segregation.
Subcellular Localization:
Nucleus.
Sequence:
MALKRSYYASKDDYSTKRILEIIERPLKKLTIEDTSEYDDSDIEMPTCKRVAYYKNEYTIVVEDLDAELEEDDSINKPTEEADEAPRTQLSVISPLEKKLKRDFLFLLLNSNRQPGKSSGKSSIPSPDDFKLSVKYSSSSEDLGAVTIESHLNVSSDASIKYKSSGTSQSDLLMEIG
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MASRDFLRVFGAGAGHQDDAAAAAGRTDDVELSLGLSLGGRFGTTDAKRPRLARSSSIASVCSVSSLHADADAAPLPLLRTTSLPTETEEERWRRRETQSRRRLEARQKRVERRNSMASLAPAVVGGTGRRSNASQGSNSASTTEQGIGGSASNQSTDARSPSSTSDNNTNQNNMLPPTTKAAEKPLNGTATEQPQPRLRTLGSLTTRTSSTGDIRKLMMEDMPMVSSKVEGPNARRIDGFLYRYKKGEDVRIVCVCHGSFLTPAEFVKHAGGGDVSNPLRHIVVNPAPFS
The following text describes a protein:
Function:
Inhibits zinc finger homeodomain (ZHD) transcription factors, by interacting with them to prevent both their nuclear localization and their DNA-binding properties.
Subcellular Localization:
Cytoplasm.
Sequence:
MGPQQDRSAAKPYANGSTAAAAAAGRKENNKVVRYRECQRNHAASIGGHAVDGCREFMASGAEGTAAALLCAACGCHRSFHRREVEAAAAECDCSSDTSSGTGRR
The following text describes a protein:
Function:
Modulates RecA activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTDLRNRAISFLARREHSQEELKRKLVTRGYKLPEIETELASLAREGLQSDERYAEAYVRQRIESGFGRRRIIAELQQRGIENSLIQQYLPRDESFWFETLSSVWKNKYGYQSVKGKPSANQVRFLLQRGFDLEQIYKLFKKNE
The following text describes a protein:
Function:
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Might have a role in the early stages of fate specification of GnRH-secreting neurons. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.
Sequence:
MAPWLQLCSFFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLHNITFRYDNCTTYLNPGGKHAIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFRRTGMESQPFLNMKFETDYFVKIVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMHVSFDHAPQNFGFRGFHVLYKLKHEGPFRRRTCRQDQNTETTSCLLQNVSPGDYIIELVDDSNTTRKAAQYVVKSVQSPWAGPIRAVAITVPLVVISAFATLFTVMCRKKQQENIYSHLDEESPESSTYAAALPRDRLRPQPKVFLCYSNKDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWAIQKIHESQFIIVVCSKGMKYFVDKKNFRHKGGSRGEAQGEFFLVAVAAIAEKLRQAKQSSSAALRKFIAVYFDYSCEGDVPCSLDLSTKYKLMDHLPELCAHLHSGEQEVLGQHPGHSSRRNYFRSKSGRSLYVAICNMHQFIDEEPDWFEKQFIPFQHPPVRYQEPVLEKFDSGLVLNDVISKPGPESDFCRKVEACVLGAAGPADSYSYLESQHVGLDQDTEAQPSCDSAPALQPLLHAVKAGSPSEMPRDSGIYDSSVPSSELSLPLMEGLSPDQIETSSLTESVSSSSGLGEEDPPTLPSKLLASGVSREHGCHSHTDELQALAPL
The following text describes a protein:
Function:
Required for thiolation of mcm(5)S(2)U at the wobble uridine position of tRNA specific for lysine (tRNA(Lys)). Probably acts by catalyzing adenylation of tRNA, an intermediate required for 2-thiolation. May also act as a sulfurtransferase that transfers sulfur from thiocarboxylated SAMP2 onto the uridine of tRNA at wobble position. Required for cell growth at elevated temperatures.
Sequence:
MECDKCGRDAVMHAAYSGAHLCDDHFCASVEKRVRRRIREDNMLPRDASPENPQTWVIGLSGGKDSVVLTHILDDTFGRDPRIELVALTIHEGIEGYRDKSVDACVELAEDLDIHHELVTYEDEFGVQMDDVVEKDPENMAACAYCGVFRRDLLERFADELGADKLLTGHNLDDEAQTALMNFFEGDLKQVAKHFDASIGDFEKRRDAGEFIPRAKPLRDVPEKEVALYAHLKDLPAHITECPHSSEAYRGEIQQLLLKLEENHPGTRHSIMAGYEELAELTAREYRGEGRVDLNDCERCGSKTAGDVCRKCRLIESIEAV
The following text describes a protein:
Function:
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLTLARQQQRQNIRWLLCLSVLMLLALLLSLCAGEQWISPGDWFTPRGELFVWQIRLPRTLAVLLVGAALAISGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPNWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALMTWAIYFSTSVDLRQLMYWMMGGFGGVDWRQSWLMLALIPVLLWICCQSRPMNMLALGEISARQLGLPLWFWRNVLVAATGWMVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASALLLADIVARLALAAAELPIGVVTATLGAPVFIWLLLKAGR
The following text describes a protein:
Function:
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSKQGFKNVPMAPALTWPERLGQYWKLVRGDRPIGSLLLLWPTWWALWLAAGGLPPLWTLFVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLSLNWLTVALSVPGLFLAASYPYLKRHTHLPQVYLGMAFGWGIPMGFAAVQGSVPLLAWLLYAANILWATAYDTWYAMVDREDDLRMGSKSTAILFGRYDLIAQGVLYALMFAALVLVGLRAGLSIAYWAGLGIAALLVAYEFHIARHRERGPCFRAFLHNNWVGLAIFVGIAASLALR
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MAASVCASGAALRAGLPSVSSRQQPVAKQSFTPLLRPLSTTRQHRLPALHKAPLSSSLFSGSQLNGAHASSFMAGPNPFAAELKRTQAKRLRAPRAVGARASLIARWKTQWIREGNKPFPTMMEKPFFFWRILAILPYLPSIFEGTLSIAYSGKFGAEAMDAVTPIATVLEWYSKIPIIPMAVFFLLFFTIIQNTKMPHFVRWHTLQSVLCEIVLTIRVFVQQILPPTYIIATFTETMFYLGFFVWFCSMYSALHAAFGLYADIPFLSDAVYIQVPMGTQKAQEKDEEPED
The following text describes a protein:
Function:
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Does not accept 4'-phosphopantothenoylcysteine as a substrate.
Sequence:
MEEANLKSALSLRNNYRAVVLGGTFDRLHDGHRLFLKSAAGLAKNRIVVGVCDDAMLTKKQYADLIEPIELRMQHVEDYIKSIKPELIVEVEPIVDPYGPSIVDENLEAIVVSKETLPGGLSVNRKRAEKGLSQLKIEVVDLVSEESSGDKLSSTALRKLEAEKLRDDHPRSRS
The following text describes a protein:
Function:
Positive regulator of abiotic stress tolerance involved in the regulation of plant growth. May be a downstream target of the abscisic acid (ABA) signaling pathway.
Subcellular Localization:
Endoplasmic reticulum. Plastid, chloroplast, plastoglobule. Note=Localizes to rod shaped ER structures that resemble ER bodies.
Sequence:
MARRDVLLPFLLLLATVSAVAFAEDDPDCVYTFYLRTGSIWKAGTDSIISARIYDKDGDYIGIKNLQAWAGLMGPDYNYFERGNLDIFSGRAPCLPSPICALNLTSDGSGDHHGWYVNYVEITTAGVHAQCSTQDFEIEQWLATDTSPYELTAVRNNCPVKLRDSVSRVGSEIRKKLSWVV
The following text describes a protein:
Function:
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like acuF, acuG and acuN.
Subcellular Localization:
Nucleus.
Sequence:
METETGKGATAPPAESSGVEQDTAAVGAPADQPPKTNANATSNANGEDQPANGQKANPKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGIGGNNFYNNNSMSNGVPSGGINMNGANTVNSAASTQNSSANFYPTPQSNYSLYQENPINHQNSFPSQSPVSPTFSLKTNPTPRNTAPNNNNNNALTSSMPQPATTGVSNAPNQSQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPDSGTHRGSMGRSGSTQFASTPIGGTTTFGESPQNQQPFMFGDPLLNEWPSGQTSGQPHVNVGVYPQSSQGNVIPGHLSKPDAPHAFAIESGPNNFTSPGAATSPQINSGGYEDANAFNNVVTKSNGLSVNGQQRPPTISTPSLKHQSLQMNKRRHRNPSAVYESVKEPYAYTSRFHSLTAFIQRRFSPQKTLQIAKALASIRPSFIATTKTLNRDDLIFMEKCFQRTLWEYEDFINACGTPTIVCRRTGEVAAVGKEFSILTGWKKEVLLGKEPNYNVNTGGSSAANSRNITPRSSVESTGRPHPVFLAELLDDDSVVEFYEDFARLAFGDSRGSVTTRCKLLKYKTKEDMEAAQSDDNGQRWNNHLRKGGIANEAGMNQLGFKDGKVECAYCWTVKRDVFDIPMLIVMNVRLPLP
The following text describes a protein:
Function:
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MNSVLCSRAAGAVRALRLVGWASRSLHPPPRGRSPAQPADREEEDDDPNLPIQFSGSKATPIRWTVEHSLGKPQQRPWWKVLPLTLTLVALVVWCYQREESGMDLWLRQVLEEEDEEEPEGPPEELEAPALYGART
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.
Sequence:
MLPSHSLPSDEEPFTSYKKMIYEEQGDDIMDTPQLGGMETGDQEGEILAGMEHLSKTQRRKRLRYLRIADTRRLHRKEKKKEAQQRKRERTKQLECLTKELPGAAGDDSTDVTECQPQECAALPVSVGNCTGITTGVGQVHVSKLERQKHTRRKLETAMKKGLRVCLDMSFGEKMTQKEASRLAGQVGRVHGANKLSARPFHVFLTSLVQDGTLHRECVRRNDGFQNFIGVEQTSKHFLEVFDKEDIVYLSPDSPNDLLELDDKKVYIIGGLVDETVQKNVTITQAKEKGLQTAKLPIDLFMQRQPGSKGNKILTVNQVFEILLKFYMTRDWRVALPVGLPERKSFILKPDDTLPPDVLKQQGVFPPGFDRGSDWGEETSEASKEDAEKDDTLKNTNIRENINFDSISTTEDNNDIKSLKQSVI
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVNPTHTALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASEPGWLRRPLRSRDTLLMAEALRTLGVEIEEGVGPEGTGEFWRVIPAGLRGPATVDVGNAGTVMRFLPPVATLADGAVRFDGDPRSYERPLHGVIDALRVLGARIDDDGRGALPLTVHGGGALEGGPVEIDASSSSQFVSALLLSGPRFNQGVEVRHTGSALPSMPHIRMTVDMLRAVGAQVDTPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGKVVIPDWPSRTTQPGDRLREIFTDMGGSCELTDFGLVFTGSGAIHGIDVDLSEVGELTPGIAAVAALADSPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYDDHRMATAGAVLGLAVEGVQIENVATTAKTLPDFPDLWTGMLGA
The following text describes a protein:
Function:
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
Sequence:
MSVSNPPSSGKPLKLRVNKDSEGYLSLVTESGEVYKCPICGNDKFVYNYERGEAVCIVCGAVVQEQLLDLGPEWRAFTSEEKGQRARTGAPLTRLISEALTTVIDWRDKDVSGKELDIKRKLEVIRLRKWQTRARVQTSYERNFIQAAQELERLRSAMGIPRPCIEQALEIYRQALEKELVRGRSVEAMAAAALYMACRMMKMPRPLDELVRYTKASRREVARCYRLLLRELNVKVPISDPILYISRIAEQLKLSGEVVKTAIDILQKAKKAGITAGKDPAGLAAAAVYIASLMHGDNRTQKDFAVAAGVTEVTVRNRYKELAKALNIKVPVK
The following text describes a protein:
Function:
Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein.
Sequence:
MDQDALIPLPPQDLGDLRDQPELQALLANPALMNHPQIAQLYAQFQQDQANLMNLPPLPPLPPVPPLPPLQQQQDVPMNQDPMLPLQPPVVPAAAQAPPPAAAAQHPLAPQFHLHMQGFMDGFAAIPVLGFAPLGPGQFPPPLRRRVAVARRLPPPPPPPPAAVPPQPQNAAGIVAGILQVAVDRAEAPAQVEGVQIHAIPVYRGGLLHPPMVFGGALAALRNVPADAPPDAGNAAEDDNAVHRGDFRLDDPMDIAAGMGLFDEDWLGPLRGDFGDDEPVERRRPATANDGAGERTPPRDVPARLEEPCEQEIHASCPICILPFKNDTEGSRTARVLSCGHLICSGCVKQFLRNLKENRTMSYHHSYDKAPCVVCQRTVHWRGIPECKTVGYLYEQLELTNDERSTVDEAAIAKIRTDARKRTHRLLDNISSSCHEMATKIRKLVRKADRVYDDSLERASHATGRETWRRIESEAHADAVVKVVQDEADRLSYLEILFNEQYVQLNKLLEEITSSPLNIPKEHPAKLLTSDAVLTLCLFTAVALSYRDLGAPGWSCDEDLMKRSKKVPENVHSLRPADIDIIAAIGDSLTAGNGAGAEGEDVLAIAIQFRGLNWAAGGDNSLDEHITITNILKKFNPNLFGYSIRTGSANVWETAHLNAGVPGAHSADVYEQANDLMRRMKDHPDIDFMNQWKLVHIFIGANDICSWCHRGDSMNADAYREHLRKGIQYMKENMPKTIVVLTGMIDINLLRRIDNAHLVCKEIHTFECKCEGNATVTDADLSGICHGYMTTMQELQDSGEFDTTDDFTLIIEPYLELTTDIGRNPDGTPNMDFFAPDCFHFAAYGHAIVAKNLWNNMLQPVGGKTAANLTDNGEPLICPDKDCPFIRTTKNSDNCASYMN
The following text describes a protein:
Function:
Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Subcellular Localization:
Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
Domain:
The signal sequence is essential in mediating its proper translocation, hyaluronic acid (HA) degradation activity and secretion.
Sequence:
MGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKNDNWLVRHPDCINVPDWRGAICSGCYAQMYIQAYKTSNLRMKIIKNDFPSHPLYLEGALTRSTHYQQYQPVVTLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGVFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSMKGCERIKIKALIPKNAGVSDCTATAYPKFTERAVVDVPMPKKLFGSQLKTKDHFLEVKMESSKQHFFHLWNDFAYIEVDGKKYPSSEDGIQVVVIDGNQGRVVSHTSFRNSILQGIPWQLFNYVATIPDNSIVLMASKGRYVSRGPWTRVLEKLGADRGLKLKEQMAFVGFKGSFRPIWVTLDTEDHKAKIFQVVPIPVVKKKKL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MAYQDTHAPKREVQRMQFGILSPDEILQMSVTDNGGIKHPVSTENGCPKIGGLMDPRQGVVDRTGRCLTCGGNMAECPGHFGHIVLSKPVFHAVFLPKIIKVMRCVCFYCSRLLVDPELPKMKMILSKTKSDFNRRQNLVYNLCKVKTTCECRSGDVETGEKMEQDVVEGCGRHQPKIRKIGLELTAEWNVLNHESQEKKIVLTAERVLEIFREITDETCSYLGMDARYARPDWMIATILPVPPLPVRPSVLNFGAARSQDDITYKLADIIKINNKLKRNEEQGAPPHILDENIKLLQYHVATMINNEMPGQPKATQRCGRPLKSITERLKGKEGRVRGNLMGKRVDFSARTVITPDPMLKIDQVGVPMTIAKNLTYPELVTPFNIDRLTQLVHRGPNNYPGARYIIKQNNARIDLRYHRKLSDLHLQIGETVERQMLDDDYVIFNRQPTLHKMSMMCHKVKISQLSSVKRMIITPQANRPVMGIVQDSLTAVNKMTRRDSFIDKKNMMDLIMYIPHWNGKIPQPAILKPEPLWTGKQLFSLIIPGQINCIRTHSTHPDDEDRGPYKWISPGDTKVIVENGQLLSGILCKKSLGPSSGSLQHIIYHELGREATGDFYSHVQMVTNQWLLTEGHSIGVADIIADYKTYMDIQLAVMEAKANVADITYKAQKGELELTPGNTFIQTFENQVNRILNDARDQTGRLAQDSLSDFNNFKTMVVAGSKGNRINISQIIACVGQQNVEGKRIQFSFRDRTLPHFLKNDHGPESQGFVENSYLAGITPTEFYFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVKYDGTVRNQAEELIQLRYGEDGLAGEWVEFQNLPSLKPSDKAFEREFKFDLFNEK
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Sequence:
MGEGETGGVAAAVGATPVLPQQKRRNHPTAVQGTNDNSILSKCSMAQLGYFDDPFLAEMVQRVTRRSPIINRGYYIRAKAVDHIMSAFLQQHADAAPQILSLGAGFDATFFRLKAAGLLPPGSVYFEVDFPTLIQRKTALIHQSSRLSAHLPEAPITSSDALSDLNTPAAQEALTQLREQHLDRAAKKAAANNAAQASDADSASEPDLATLLGHALLYEDYRAVGVDLCKVKQLRLRLQAAGLLPDRPTLVLSECVLTYVGPKPAFAVVKWSAEYLSNAILVNYEQIEPDDAFGHFMQGHFTRIGSALKGIGTYRTPRHHNERMIQAGFTTAEAATMGQFYRFLLSDEERLRVDALEPFDEHEEWQLKCLHYIICVAAKGNNLVNFPRNTLASCLRSVSISAESYLNDAALPPPATPAVTMVAPLGEICASAENVVAGDLQRFGHASLATANGLLLHGGMGGVQHQRQDNVLCFLPTLAGLRLGPIVSGNGARMHHTWTPGAQGQALLCGGRTSPARPCTDAWLHHNTDQWLALSVDNKQLLARWRHTCVFLADSTQGYLLIGGQTASRERPSPRSCDDPVVWVTLDVPNATAKVETLAVTSAPGASRHSAGLARHSHCCAALADASAVIYGGLDETGHILSDVLRVQRASDSATLVVQKLQFQPALPPRFGHKVSADVATATMLINHSVAAVEDQVYITCGGGNCFSFGTHFNQHMLHVSATDLLAVSRPSVPITTSHTLTEGAFAVRLTERQPFLVRDCAFGVATASWTAEHLSSLVGDREVSVHVGEDCNMDFTTRNFRPMYLRSMGKNFRKDVSNIEQTFPEVAAEFALPSCVPSWIMGEKLFSTALRVSSPGVQLWTHYDVMDNVLCNVRGRKRVVLFPPEQAGNLYLEGSSSRVVDIERPDLEAFPRFATAMAHALELILEPGDMLHIPALWCHNVRALEPCISVNVFWKHLDDAALYASKDLYGNKDVKPAAEALRLAHDAAERLQTLPADHAAFYGAYATALLQPTNP
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MIVRNIGARLGRRALATPLSRASFPAQSRFLSQDNFTAPPPPPTNSKKQAAKTAFAEPTLEEQAEFYAESIEKHTPEFAASPAAEAWSAPSATATETVTTWDPSLVDEEALKLKQQIEAIPGNFKLFKQTKAQTQKLGAGVEVRYIPEQYLRNPPSDASLEDLMAAQAHMGHNTSLWNPANARYIYGVRQGIHIISLETTATHLRRAARVVEEVAYRGGLILFVGTRPGQRPIVVRAAELAKACHLFTKWRPGTITNREQLLGGVPLTVVDELDRPLSGFEDHLHDRRPLAPDLVVCLNPKENMTLLYECSLAKIPTIGIIDTNTNPSWVTYQIPANDDSLRATALISGVLGRAGERGQKRRLEAAQRGVVTWKTPADVQGYFELASARAADARRRQAQDNSVEEQKEKDTFLSEDALKAMFGGDARI