lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Possible sulfate transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MYKKMSLRQLFSDRPPLNAVLQEKAQKLRYACSPSKCIHSLLSFLPIITWLPKYDWSHSFFGDLSGGLTMAVFSVPQGIALASITGVPPVYGLYTAIFPSFLYIFFGTSKHNALGGFAVLSLMTHGAIEKVMLRTATSYNATAYVNHTLDELLDKENETALISNTTLMQILGNETSFVEEVTMEMWTEGVTPVKQIHVATTIIFLAGVIQVFMGVFRLQYLTSLFSEQVMSGFVVGGGIHVFFAQIGNMLGIELPRRSGPGYLYYRIWDLVENLDNVHIPTVCISLSSFLFLVFGKEYLAPWLNSAFNYPVPFELVLVVVGITATNYAELSLRHDVKVVGNIPTEFPPPSLPRFDLIRHIGLNAAAIAITAVAIHITVAKVVEKRYKYKINHGQELYALGFVGVLSSFFPVFPVTSGFARSVVGAAVGGSTQLTCLFSSLALLSVILCIGPALEYLPQCILSAMIIFAQKGMLEKFGELKSLWPVFKIDFTIWLMSFFLTVCYDMGEGLLMAIGFAVLTTIIRTQRPKWHFLSRDDDTENYKETKKRDLERIQGNVCIFRMDAPLIFTSSDRFTMSVWQCVKKWERCKSESFVTIEQMNSDRSADIFDSKLKSARRRWKRDQKSENRCKLVIDCDGFPYVDYLGLSTLKSVYVDLQAAGIQCFFVVQKSDLKKLFRATDFYEVVDESKVFNKVGDAVKAAEQHISSPKTTKEILTALASIATTDTVLIDEESSDSNDNDDAEIQERITEESENSEEVMSETSVSIEDATSLTSSRNSINSEE
The following text describes a protein:
Function:
Probable component of the nuclear pore complex (NPC) (Probable). Plays a role in NPC assembly and/or maintenance.
Subcellular Localization:
Nucleus, nuclear pore complex. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore.
Sequence:
MERNLQKQLYGISRESSPGARRYSMPAASADSTRKSIFGGSASCAQMSGSLKRTALTNSRLSLSVRSTQSIAGIRSDYNSVESFGCPLPVVVNEALTFAGPGAGTVTAKVTQNGWAWVVQGRRLLIWQYKDTAKSGSPPRVGKLARRGGGLAQCRELTLPYSDLGHKSDLISVFQTEGQQMASCIAVSATGEVRYWSSIAHDGNSVDLSILTGQEFVQLLSLPTQQGYLAVTTTCNLVFLRVGLTNGRYTLHHKTIKPATSFLGGFGKKFASILIGMNTGADKDQTLVGMCCESNLESGETIVAVLSDRAIQRWSLSNNGNTENLLYEDADMLRRIREEFITNFWKFRLPADSLEIDLHLLDFHVVKNKAYILAGAVNAAHAPQMCYALVTGTAQAERMLLESFTPLNMNKFFSAKTEEDCLSVRFVVGSSHIYLYTSKVVYPLHLTNSVPTAELEAEKIEFHQHDDRILSAVICSQLPLFFSRTHGLVSITPGDFDGTEMMNMSSCNTPDLYAPNSCNASFAVADHSALTNSTNNLHLFELDPDEMYNELSDEVGQLKAAFLYHMKRNSNMVKTIVDELLRNVTAADPSGAPMDAYKLDRIVITIAEDLAEDIPIADPRWEEALADQEMNRHAIGSSRSMQIINQLRDKIIAFQHFITFLHSSLVWDKLNVIPCGSHSLKPTGCILADISEKIVAAMALRSIQTKLPKLIEEAIDATVALWHEEPQGSLTYQDIFYVKLSRFQNVFEALADIADDRIAAQNQTTISVAHFVNEINSIVLDVLGQVFKYRKQHASSFRLSHEKLPSYENLPWTAMAGSAGVRDTLTRLIDISVRYGSHCVSETELKQQLYQQIFELIDLVLDGRKTYLKSVRDTEKFNVLQQQFEAQRRELISVLIKDRQYEYAAKIAEKYLDFQSLVLICDETQDKERLEDYTRKYEEYDFSQFAINWHLRQNRHGEVFERFKGNQTALAQFMRDHPSLGWIQLIFNGDFERAAKVLYELAQCETEFVARKKSMLSLAKLAAFAAAESDLTAQVEKINADLTLVEYQSQLGHDVLESFGFDPAEQKVLKAEEIISLYIAEENETASETEFRKALELLSYVEQPYDMRHKIWCAAIKRDNWTDYDPNNAVHYMQKLLFYKIIEISQLMGNDSENVLPPMEDFLESVELGDLPQQKPFQYLLKLTYEYVADMFKQPDDMEL
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MVGTSRGSTRSRGSKSSTENSPIRKPNQMVRKDKTRDRSLIRIFSVNIKFLLGFGIIAFAISLFFINSLIKPMEKPQKPRVITXISLFFINSLIKPMEKPQKPRVITPLPAPKLMDLPMFQGDHRESLYWGTYRPQVYFGVRARTPQSLVAGLMWLGVKNGRYFMRHVCQDSDELKQYGWTSHNGRDYGHQFLIEQTMTLTTHFLKSKDRGSGYGGDWAVRIGVQSDESMSDEEMLNTAHLFFYVADESGKGLTLGSGVSDIHGDSILASGSRSDIGNWQLHLFSEDVSGVHYSGFKTPHIHNLSDVVQANLAVQARKFGHLLLSDLSDDSPNILVFQISARIPLKADIVLLSGTSARDSRVEERASRLKGTSLTSLLSEKQNEFDNKFKKSFSLSDELGLDPVTVGKAALGNMLGGIGYFFGQSKISLPSTSTLNAGDNSVLYWPAELYTAVPSRPFFPRGFLWDEGFHQLLIWRWDIYISLDIIGHWLDLMNIDGWIPRELILGAEALSKVPEEFVLQHPTNGNPPTLFLTLRDLISKLKKEKFAATETRDISVFLDRAFVRLEAWFKWFNTTQAGKERGSYYWHGRDTSTTRELNPKTLSSGLDDYPRASHPNGDERHVDLRCWMHLAADSMHSIAELLKMDKDIQQEYSLTAKLLSDFEVLNQMHLDAANGAYCDYGNHTEKVQLTWKIVETDPKRELLRQVLEKPVLQLVPHLGYVSLFPFILRLIPPDSWILESQLEFISNRSILWTDFGLRSLSKTSSMYMKRNTEHDPPYWRGPIWIPLNYLIVSSLHHYSQESGPYRERAKTIYNELRSNLIRNIVGNYKRTGYLWEQYDQKKGKGKGARLFTGWTATVLLIMAEAYPEV
The following text describes a protein:
Function:
Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
Subcellular Localization:
Apical cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Dynein axonemal particle.
Sequence:
MGDLELLLPGEADVLVRGLRSFQLRDMGSRGWNQQHENLEKLNMQAILDATASQGEPIQELLVTHGKIPTLVEELIAVEMWKQKVFPVLCKLEDFKPQNTFPIYMVLHHEASIINLLETVFFHKEVCESAEDTVLDLVDYCHRKLTLLVAQSGRGAPPEEESQYSSPMQELQKQAELMEFEIALKALSVLRYITDCVDSLSLSTLSRMLSTHNLPCLLVELLEHSPWSRREGGKLQQFESGRWQTVTPSEQQKLSKLDGQVWIALYNLLLSPEARARYCLTSFAKGQLLKLRAFLTDTLLDQLPNLADLQGFLAHLALTEAQPPKKDLVLEQIPEIWERLERENKGKWQAIAKHQLRHVFSPSEQDLRLQARRWAETYRLDVLEAVAPERPRCAYCSAEASKRCSRCQNEWYCCRECQVKHWEKHGKACVLAVQGDRAK
The following text describes a protein:
Function:
Modulates actin dynamics and cell motility.
Sequence:
MDVDHEVKELVKFIKKLGTKGADGKYSVKYGVLFNDDDVANFFEALVGTLKAAKKRGIITFQGEILLQRVHDNVDVILLKDE
The following text describes a protein:
Function:
Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
Sequence:
MTFLEFLKEFFSWRDILDIFGLFLFFYLFIRFLYIAKGLYILRLLIYLGILWLFAEVLSLTTLSWMFEKLWTLILFTLIVIFQPEIRRTLANIGKRTKVIKLKEYEERSIDRIVRACRFMAERQIGALIVIERQQNIEDLIEGCIYLDAYITAELIITIFYPLTPLHDGAVVIRDDRIAFASCVLPLSKNPELPKKYGTRHRAAVGITEMSDAVAIVVSEETGEISVAVEGNIEKILDHELLKDKLMELLGVKHGS
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
METGRGSPQEQPQQQQLTIFYNGRICVCDVTELQARAILLFASREMEEKTRTPTASDAISPSLHSQIYSPTGLSMKRSLQRFLQKRKNRMEATSPYHR
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MYYQRLGQAQPGRTICTLEAGMNEVEVYQRVKKIVVEQLSVEESEVTSESSFANDLGADSLDQVELVMALEQEFETEIPDEDAEKITTVGDAVTYVLKRGSEV
The following text describes a protein:
Function:
Regulates centrosome duplication (By similarity). Controls the secretion of the tyrosine kinase receptor let-23/EGFR from the endoplasmic reticulum and is required for the localization of let-23/EGFR to the plasma membrane of vulval precursor cells. It thus plays a role in positively regulating let/EGFR signaling, and anchor cell and vulval precursor cell alignment. Plays a role in vulval development and morphogenesis.
Sequence:
MVDESKLQCYHKGCGLLFDPKENDNEACTYHPGGPYFHDAYKIWTCCDKKSTDFGTWMNYKGCTRGKHSNEKPVDIVKVAAVKEIRPEKEEDVIVWKGLNKSGKLDSKDATKRIEQNLNVEVTPGATAAIEKKLKEISEAAQSADIQIGAPCRNNGCSTEFDGSKNKENCQHHPGAAIFHEGMKYWSCCNKKTSNFGAFLEQVGCTSGEHKFRNNEIVSKFREDWFSSNGFVTINVYCRGALPETANIVSDGHTVRVSMKHGFGNASVDLDYDLWDEVIPEESRVVIGERKVEISLKQKHGTGWPRLKFDPELDAKNDEEA
The following text describes a protein:
Function:
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
Sequence:
MGLRAGGALGRAGADRGAPEGPGPSGGAQGGSIHSGCIAAVHNVPLNVLIRPLPSVLDPAKVQSLVNTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQQETIPAKLVQSTLSDLRVYLGASTPDLQ
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLPRTPLFQAAKTFTSKPRGARKPAIPLIAPLPLYRQLLRAHRKHLDPDRRSLGDMYIKSEFRLHKDIQDPLQIVGFLSQWQKYLEMIKGDTWRQEKLDLSVLQKMSDEQIVQLYELMQAAQDEKSEYGVFDDLTDKR
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MKRCDTVATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNNEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCHHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKIK
The following text describes a protein:
Function:
Has a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MSNEWGNDWNTDSWNTGYSQPQQPSAPPAAPAAAPQDQSYGGGYYSQQSSNQGFDGYGQQSPTQNQYGGYGQQQQQQQSYGQNNGFGGFQPQQLMSDPMLNAAKQFGGQFAEQQKEKLTKYLGTFNLKYYFAVDNAYVGKKLGILFFPFFHKDWSLKFAGSADPAPAREDVNAPDLYIPLMSFLTYILVSGFVLGTQGRFSPEILGILTSNALIWVILENIVIFISKYILNISQSLSVWHSLAYSTYKFAHMIVCLLLFMVGDKTFYYGALAYSSLALVIFLLRSVSHFMFDSSGSYGSEEGRKRKLILVAFVVITQPLIMWWLTSVASNYDYDKFGLAQMALSKMTGGSGSKAKQFMTNDGDIDYEALLKMPKDDFEGM
The following text describes a protein:
Function:
Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MEGDRVAGRPVLSSLPVLLLLPLLMLRAAALHPDELFPHGESWGDQLLQEGDDESSAVVKLANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGRGRVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDLKSEGPYFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSFSHATALESDYNEDNLDYYDVNEEEAEYLPGEPEEALNGHSSIDVSFQSKVDTKPLEESSTLDPHTKEGTSLGEVGGPDLKGQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPENGSIQPYPDGGPVPSEMDVPPAHPEEEIVLRSYPASGHTTPLSRGTYEVGLEDNIGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSSRDYSLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTGRK
The following text describes a protein:
Function:
Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.
Sequence:
MSSKGECHVLRPVANFSKNIWRDQFPSLPSSDSVFDSLTKEIIPLKEKVKEMLKASTADPMENVKFIDTLLRLGVSYHFENDIEMQLERIFNSQENLFHKDDYDLNSTSIAFRVSRLHGFKMSCGVFEKFKDGSVGKFKESLVDDIRGMLSLYEAAYLRVHGELILEEAIAFTKANLKPLAAKSSPHLAKQIMNALDNPLNKCPPRLEARNYISFYEEEESRNETLLTFAKLDFNRVQVLHRQEISQIARFWEDYDFSSELSYARERYVEVYTWINSLYFEPRYARWRIILTKMLVLMSILDDTFDAYGTPQELQRFTDALKRWEISALDELQDYTKVICKAVLDLFDEIEDEARKEGRSYTVPYAKDAFIGLINNYQAEVKWCHDGYVPTFEEYMRVAMKTSTYDPIITTSFIGMGTIAGLEAFEWLQTEPRIMTAANMIGRIMDDIASHKFEQLREHCPSSVECYMKQHNLSEKDALHDLKKKLEDGWKDINEECMRPTAIPRDLLLRILNFARVTYLFYKHGDGYTDPDPYMKDDIRALFVDPVRI
The following text describes a protein:
Function:
During infection, may play a role in establishing and maintaining biotrophy; the formation of a tight interaction zone between the host and the pathogen.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAAGKRRVASLVLLMIIWWSIVSAAESQCEERNDYSRKRPSHKPFTSHQNKQDRSCSSPLPSESCSTSAITPSDSAVRDTSLSRRGLPGMPGDIEWMGFYGSLLAVPTMLSILGIITNYNLGKSYYNSELNAQYYKQSREMLRAHTAKLIQDQEKKFANAGVSWNGMVYGKDGQVNPGAKLPEWNGRVLGGTVANPKSQPVPGSGGAVQGAAAGVGGGTTAGVAAGAGAASAGTGPAQVGGATAGGAGAEAQTGTGAIATGTGTGGAGDAGGSAPVSSGAEQGDAEAGDEARGSEERGDDGTEDRRGGQSEGDDDSDSDGNDEGDAGDAGDAGDA
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MSSWIQECESALCACLGSSSFEQLLASLAPSDSQGQCTALWSAGALAYRCRTCQLTPSAAICVACFRAGGHEAHDWVQYRSQSGGCCDCGDTTAWRSRGCCPAHKPGRRVPARLDQLLPPQPRAVVQAAVAAAAARLTECLTSLCTGRPSPARRREAVEMASWLLRLAGAAPPLRRLLCDELCRPLPPPPPLPPLLLPQSEPAAQAKPDTQQQQKQKQQHHAGGLDAREGKAAGAEGAGTALGGGSSGGVGGGGPGLGVGPGRPAGGYVPPALLAGCYQQEAAEALARLPRRDPPPPLQPGAPPAQDCQLRRCVLALRGLPPEPLQQLASLLLLLLYEPAFKEATALHLMESYTPIMSAIAGLAPPPATAAAGGAGAGAGAGAGATAAGGAGAGAGAGATADVGAGAGGDNGMGDLAPAWEAAGGEGGGSPGGGGGGSGGGRGGKHPLCGVLDRLVVQVFNAEVVTARLVREHGVLRSHLDALAYLTTAFVDELHRLAAAGAAAAAAGGGGGGEEGEAGGVSPQAAAEAEARLHSVLDGLRRLASDFSNFVHHLGVARLLLADPRLWADAFLGRVLRPLQGMLPHVRRPSGDVVERYGGVGVPAAATAEFVAFACVAELVATVSGGNSGGGGGGGGGSGEGKGEEEEEEEEQEEGEEGAEEGAEACGRPAGGCGAEERVALLYEAARQSLEACEEWCSDRLARGSSRLLPAAAAASDPTAAPTAAAAVQPLSYDVSGLYDRLLAGAVEVSPHLPLHRAALFFVQALLAAEQGGGAASAASAASAAASAAAPDPRQQVAARAAAAAALPRLLAARAPQDGGSAWRPLSRYLLAAQAFVIQVSSRRWLRNGDDVAAVELFALNGREMSDLDTLGLQVWLASADDPGAAVCEALCAMGARPLLAAAGVPIPTADAEATTTTTAAAAAALPPAAAPSELSDPATAAAACEALRWLVSLLRERGVSGLPARERLRLFLVQWLALRDWTYNQLHELLPHDLQHRHTDMEQVLAEVATYRAASLSAARTYSLRRAAWGAFCPFFAHYTPAMRSRAWQSAMDTGWAAAAGGGGGFGGGGGGFGGGFGGFGGGGVVGQRDGGDSGGGGEGGVAGAGVVGYRPCWQLRRPRYALPPSLAPLLRAVEAGALWRLVGWILQAEAMARLRAQQQAFLQRAAAAGAGGGAGGGGGVKQAGAAAAFGLSSDSDEDEDEDGDGDGEAAAGRGPTHGAAAAAAAAGAASAPASAAGVSGAQRMDAEEAAGSSGEDSDDEMGEGSSSGGDDEGNEEEEEEGEEEGEQDGDGDHGSGEEGESFAAPGPPRLPEEALLGGLNLLALALHRAADNAASLAERGGGGGGGSCGGGGRGPEGAAAGGGGGLQEQQGKEGMEVAREVESEADGEAEAERRRLLAACSVAVAALTGTQPVHTLPAAHHKQHHSTHHHSSQHRPQQHHPHYHHHHSGGIAGLIDMLLRTDRERGSSTGGAATGSASPAVAAAANTGGGAGVAPAAAGAGGGGGGGGGLAELVSDPLMLTLQLLAVGLTALAGAPVAAGAAAGLPTSPQQLLRCVLLAVWPLQVVQSALWRAATAQSAAAADADSGASGTSGTSSHADLLRQLYRRALSSDAFSPPLPSSSSGCLCAAVLPFLVRAYCLDCALARTQPDAALMVVQSALWRAATAQSAAAADADSGASGTSGTSSHADLLRQLYRRALSSDAFSPPLPSSSSGGLCAAVLPFLVRAYCLDCALARTQPDAALMAQYAALPLNHSGAAAAAAGSEEAGAAAGAAGAKVVQSALWRAATAQSAAAADADSGASGTSGTSSHADLLRQLYRRALSSDAFSPPLPSSSSGGLCAAVLPFLVRAYCLDCALARTQPDAALMAQYAALPLNHSGAAAAAAGSEEAGAAAGAAGAKAGGGAGGAAAAGGEQAAEALARRLAAALGLPEPAAALREPQRLSRRAGAVLAPSVAAASAAAAAASGGGGGGGGSAGGSSGAPGSGLAARLEWEVLGAVLSRWCGARALALAVPPSTSTSTTSSPSQSPLPPPASTPAAASAVALAPTPTPATAPAPAVAALLPAAAAAAAPPAWHRGLLPPPSLVPLPPLFQSLFLHTADVTCPECGAAPDNPALCLLTGRFVCSMWRGCRDGRGGGLLHAREHCGGTCLLLSLRSTRVVALRGGRLAVCQSPYLDAHGDEDPDLRRGRPLFLDASCSSALERLWGGAALEFETQLLHNSRADLVGL
The following text describes a protein:
Function:
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Domain:
The CRIB domain mediates interaction with CDC42.
Sequence:
MPVMKQLGPAQPKKRLDRGALSISAPLGDFRHTLHVGRGGDAFGDTSFLSRHGGGPPPEPGAPPVVAPHSVAPPAAPQPPVAVPSPADPLLSFHLDLGPSMLDAVLGVMDAERSETTATKPDGDAHPRVQHPKTRCCSNADLQLDDVIGL
The following text describes a protein:
Function:
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Also promotes activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Sequence:
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRLANQSRVLQGAFARATVVGRASAVTHVRFMSDSTDVPPSDQSKPSFRTDKRIESATPFAEPSEIPSADASLLPRTNRVEELQFEAKYTLDAKTKEALDTIEELGFKTRQNLDPERFSDEELDPRNWTGLEFHEVVTRLHNRQFKLGSAYSQSEEELRQLVRAGRVAGADAGVIRSAYHGKHSVVEKNEEDDDLLDADHVNEFMYDDIPTAGHMQVEKVRKMRHLQRMSAYVLPRLVDYHVPFDVKEADKKASPLTFKYTSYTGEEADEEAKVVCYFDPANLGLSDKGLHKFKLLSGQNYDALTGQCKFASKRHPSAPENKHYLLTQILKLKTEAEQGDSFEDVPLDTRHARNKAERIAKRDRYRLAKFPEEWNRPEDKAKQTAFKALFG
The following text describes a protein:
Function:
Involved in osmoadaptation.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSHLNGSEPSRAQRETEGRWEEKNVLCDQIKEIIAALNDIRTQLAEQNKYLDVLTETYVRKPAPTHLVFAQELETGGWEEGSDWGEYADFAQGEILPAPGLEYEGSCEQNYEGKYKGDYEENYEENYEENYGEENYEEVKGRYREEEKESPKVDSFHVNETAASRNQREPILAESKGDMQKQKCYSLESTGPSFYLPLGLVISAHVSQASFTTVFIILSLAAYIFATFTLWFLREEDWVKRIIGSWRLAKANASASANSNANAITDSIQADQDRGSRIPDLLRRRQVLETS
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Sequence:
MLRCSNATALRTQFSRNIALRVSTSLDSPWTRLPRRAVSLACATTTRARAGPNGSRSFPAGTSRPYSENSAPEKSTPGNPVLETQMPPTNEAIALRDLGVPEPGVPSGRKSPVRPRGSGPDALMLIAMNKGESVAKKAVEMELAWLKDRTVLAERVQRLLKQDNIAFAAELVRTAQRRHYDTQGAWNAILAYCFGKGHAEAAFRFWNDMKKRGGKPNSFAYTTMLRGMGHVDRTPHVDPMSMARSIYQNMLDPDSPVEPTLIHHNAMMTACGLHGDMNLLWEIAGSLPEEGPGSPDVITYTIILNSLRRQIQRQAAKLGAHEYGAEKTFNARLSAIAEGKRIWSDVVYRWQKGELEMEKSNELVSSMAGLLWEGTGDWHLFEVLKLMHQTTGIPILAKEPSRQVHIGSRRAHSRQGTPLVPEEREDVPLVDRMGRKLEDMTPKRNPEPADELEKEEEGDYEHVFDSFLPSSAKPYAATQPASEQPELMRSTLRKSVYSRPAPQQPPPRYTLPKEPEEKGPRYMPIGNRELSIIMETCLQMTNAVQSGKAYWNHLTKEDNGYRITPDRRSFIGYLRILRVARQSRLSLEVIREQMIPQGIESGLPFHIAMSTCRRDRNNLNVFKHANDLLKLMDESLMIPDHRAMSSYLDLLKVLEDNPQLLMGLNGLDPSKQSNPNFQHMRKELVVNLQTVAADNLRPLVSTLDDALEASLKGRPDLSGRHGVDPELLKLQKVSGDKAVAVLARIRSLLVAILMPNRENILPKEDRERFEKDELLLRKYTKADVIENFRKRMIYPTAERQDLYYKRFKPQNENIFEETDALTVY
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MGDAEVDWEVVEEELSQLPDAWKQARFDSLPHVVDVLTASEGGILDGLREQRDAVEELVDDVVQGYHNGFNRAIHNYSQILRLFSESASKMAGLKTNLGEARRLLAARHKALQQQWYRSITLRHVLQLLDQIDSVAKVPARIERLMLERKYYAATQLLLHSSSMLEREGIQGVGGLRDVRSDMQRLRQGLFTKVMEELHLHIYNQGTYSLASTRIADKDDDARPGQKRSVRKKGSPFSPLRLVGSTDDVRLRLGGTPDRNGRPRGDDHDGAMSEDGSISGSIIASVTGSDIASLPSSILRKSSSQARQQSGQLPIWLTDATPNEFTDSITRADSHDSVKYLQTLVECLALLGKLAAAGSSLAQRLRRTLRELIADVIKARAQAAERARPRVDSIPKTSAGGSPMTFSGASSHGTKMVAHSPRGGFAGGRIGVTSAGMTSAAGGGPTGPASVAAQQLLEEVFGVCVGALENHRLVHTFMQMRGAEDQSARQVLSPPRDENSGDGFKAGGGELAPYNLAVAWSCVQSECQALVCEVLRATPAGVSADPTGLGEGVKEGEKKAGAPGGAAAKEAEGALEGEDEELAFAFRFTDLGSALPGSETGSSTLVRGGDGALQSRSRRASATGQETYETELVLPERGVYLAAAVYRPVVQFTDKAAQIVKDAALKQGGGEALRAWMEKYIANAFLPRVQNDYRGRIADALSSPAAFKPRGRTSETYDRTVEKGRPVLQGGLAAESLVLEVLAWAQALPLFAGQLVGVVQAMLERLLERCRAAYTEAVLGSLSSALAARFDFENLQKRETAFMALFAEPAGGAGQLHVAELEGREEEAEALEEEMFHLIEGQQPIKSEHLIMDFSKVVLLAALSDSLDWLGDVISQLGSGGMTSSSSVVSPVTSPLQERERARARRPPPLSAQHRRGSSQTLTSGLAILADKFHNLSVEFIRTLRLEMQLQTAYHFQDMTDRSYVCDVEPEEPDEYVLSLTTQMSRLDDEVSSYVPPVRRSYAFGGVCGIAARCAIANLGRMKAINHLGVRQVARDCIALQQTLANLGTGGDYASLQRAQAKFDRVRQYYELLTIPVESLIAFAQDHPGAYSPEEFRKLLMVQVPGREVPTDAMHKLVRTFAR
The following text describes a protein:
Function:
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MFIYLSKKIAIPNNIRLKCVSWNKDQGFIACGGDEGLLKVLKLETQTDDAKLKGLAAPSNLSMNQTLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLAHVAWSPDSKILLFGMANGEIHIYDNQGNFIVKMTLNCLVNVTGAISIAGIHWYHGTEGFIEPDCPCLAICFDNGRCQIMRHESDENPVLIDTGMNVVSIQWNHCGSVLAVAGSQKAIALDKDVNVVQFYTPFGEHLRTLKVPGKQMMAVSWEGGGLRIGLAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRLEYCVVFWDTKNNEKYVKYVKSLMSITTCGDFCILATKSDDTHPQEDTEAESVSAMVASENIRKYVLVLCNSIGTPLDSKYIDIDPLFVTMTKTHVIAASKEAFYTWQYRVAKKLTAMEINQVARTRKEGRERVYHIDDTPSGTAEGALDFSKAFTTTRDPICCITATDKTLIVGRESGTIQRYSLPNVGLVQKYVLNYRAYQLSLNCNSSRLAIIDITGVLTFFDIEVRTSESSGHQSAGDPLKFERKDVWDMKWATDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLKTAEQAFVRCKDYQGIEFVKRLGNLQSESMKQAEVAAYFGRFEEAERMYLDMDRRDLAISLRIKLGDWFRVLQLLKSGSGDADDALLEQAYNAIGDYFADRQKWVNAVQYYLQGRNQERLAECYYMLEDYDGLERLANSLPENHKLLPDIGQMFVTVGMCEQAVSAYLKCNQPKAAVDACVHLNQWNKAVELAKNHNMKEIGSLLSKYASHLLDKNKILDAIELYRKAHHFLDAATLMYKIADEEAKKRTKPLRVKKLYVLAALLVENYHGQMKSTQKGKAKGKKSEATSALAGLLEEDATSSDNRIIDSAWRGAEAYHFFLLAQRQLYEGYVDAAMRTALHLRDYEDIIPAVEIYSLLAICASANRAFGTCSKAFIKLESLESLSAEHRQHYEDLALEIFTKYSPKDNRKSELDSIPEGGEGMLPTCIVTGRPISEYQFWMCSVCKHCALEQEITNHSFCPLCHSSLA