lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
MFPVFHLSGESRRQMLQTALRFPHVFKARAEDSHKGTFGTLAVVGGSAGMSGAPVLAASAAMYLGCGKVWAGFNQDTLPFAVIAGFPEIMLDTADSLAKRQDINAWVVGCGLGTGRAAVGTLAGILTEHTDKPVVLDADALNILSTDAETRNLARGCKNLILTPHPAEAARLLGTTVAQVQADRTAAVRKIGAIFGATVVLKGHKTLVASPDTEIYVNESGNAGLATAGSGDVLGGIIGSLLAQGVPVFEAACAGAWLHGAAADVIKESAGIAAGLLAGEIAPAARWLRNRITKSM
The following text describes a protein:
Function:
May function as an adapter protein.
Sequence:
MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDLDFEDPYEDSDSRLEPDPAGPGDCKGPGDAKYDSPKHRLIKVEAADMARAKVLLGGPGEELELDTEYSDPFDAQPHPPPSDDGYMEPYDAQRAVSDLPCKGVQLYDTPYEEQDQDPGDGAPSGRRPRQSRLPQEDERPADEYDQPWEWKKDHISKAFAVQFDSPEWERTPGSAKELRRPPSRSPQAAERVDPALPLEKQPWFHGPLSRADAENLLSLCKAGSYLVRLSETSPQDCSLSLRSSQGFLHLKFARTRESQFVLGQHSGPFASVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
AWDRRRQREREDWGGAQDSAMPAKGKYLLNEQELKQVALYRQYCCISQYQLLVLMLGIAIVCCAALLVLFFAYGLLALEKSARDHCAFVSVVGCVLAVLGGVFGLVCREALFQRWMRALGVVVWACLLTMGFVFIFCGSVIRAWDQVPFFLFIIFTIYTMLPFQMRDAVILSVLSSLSHIIVLSVALTTFRPAPSESLANQLLSNVVIFLCGNAVGAFHKVLMESALRQTFQDTLSCLEIRMKLEIEKRQQENLLQSVLPVYISMEMKLAIIERLKECEDRDAQQRVVKDNNFHSLYVKRHENVSILYADIVGFTRLASDCSPKELVIMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPKHAKNCVKMGLDMCEAIKQVREATGVDINMRVGVHSGNVLCGVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITDATLKHLNKAYEVEEGNGHLRDPYLKELNIRTYLVIDPRSKDQSSNSRHLPKPKVNDGLKMRASVRMTRYLESWGAAKPFAHLQSREGFTSDALANGKLRKDMPLRSISGPKTTDRNKSQKSKFDEELHNKMIMTIDGLSSSNVGDPFLRQWIKSEEIFSLTLWFTKKELEKQYRAIDLSGFKYYIACATFIFFCIFVVQMFVAKQSTMLGVSFGVSACVLLLTFSICFAGNLLRCFPERLASCQWLGTMSEAVVKKTFVRLPLAIVSTAVILIIAVFNLCIFTQPDRCNPDYIPSNASDSSNVDFGLFYLPVSTTHSQRRAGFQMYSVYCCILGLVACGVFLRISFEVKLTFLTLASMVYYIIILYSKKELFDCYSKVLYNISNGSVLQESGIMKDPQVMSCVYITLFLITMLTLTRQMEYYCRQDFLLKNKNRQEQDEIETMENLNRLLLENVLPAHVAALFVGENKKNEDLYYKSYDCVCVMFASVPDFKEFYTECDINKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAAAGLSVTPGQENNQDRERQHTQIGNMVEFAIALMGKLEGINRHSFNSFRLRVGINYGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETSNILKKLGYSCECRGLIKVKGKGELTTFFVCTDMSKSLGLALS
The following text describes a protein:
Function:
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MSKTPEDVLQTMVEQTANSYYNSPSDLVVSFIHAAMTGLGFDLIGNTGDQASLSKESTADKNKLPFDWNASTDAYSLSYLFSKTLTTYLVKAVKMGNKLIVHGMNLQDESVHDFTVGINTVVASSAVFPFKVATADPQTLATPWESTRLSLLFVSRERAEQLLHDFKSSMIDALLKEQAHTRSGQSYKAIDPMLVTAHDSIIRDHRPPLSIRPDTETKSGTIETEFNSHIPNRFGVGDVDLDPLAAAPGMMNPIHGFPKGFGSGPMHPGGGMIVGPDHPMFNNPVNPLYSAGGPPGFPPGAVPPGARFDPVGPFGQRPNRYGGFPNRQPGQFSGDPDNDDLLPPGHYDMYM
The following text describes a protein:
Function:
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
Subcellular Localization:
Cell projection, dendrite. Cell projection, growth cone membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Recycling endosome.
Sequence:
MEPGGKMQRRKGGAPSAGPVGALILLALLGIVSGAPNHSESRPPPNPQRPWHGQHDPYAQHDTSVHDPTIRSSHQSPPIGYSVDDPPPPPPPPPPARNSQAPKETRRKASKGPQNNQASEPVTTTMPPRVVPNQFGGASDQTGGGGQTGGPERTGGQPGGQNSGQSGQTGQTQRHVPVILVPTDPPARQTASQIYEAQEKTSSSQTESPSQGQGQTPGQSPAKQNPKPPQPAVPVPRATPLPLPAPSPTPTLPPRSGGIFKGDYVVKDQNGSICVRGAFNARLSIWYQSKRGGKRTVDQAALEVPQRPVITGRCGTDKEPAVMDLRWAKGRYRLKLFFSVNTNGSKTSWLVSGVHFKYDTNDASFVKPLSTGPHTVMSAPGTDIFSAPISHSYKCSSRLQVDMTAPDGEEATLVLQDTQIQPFHLGKNGNYGTRRECGADHYGDVIPLAVGLGLGALILLMIVAYYFHRRYQGPPYENM
The following text describes a protein:
Function:
Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner (By similarity). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (By similarity). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (By similarity). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (By similarity). Required for the maintenance of inner ear hair cells. In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response. Facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (By similarity).
Subcellular Localization:
Nucleus. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
Domain:
Zinc fingers 3,4 and 5 are required for DNA binding and for interaction with SPI1; The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.
Sequence:
MPRSFLVKSKKAHSYHQPRSPGPDYSLRLETVPAPGRAEGGAVSAGESKMEPRERLSPDSQLTEAPDRASASPNSCEGSVCDPCSEFEDFWRPPSPSVSPASEKSLCRSLDEAQPYTLPFKPYAWSGLAGSDLRHLVQSYRQCSALERSAGLSLFCERGSEPGRPAARYGPEQAAGGAGAGQPGRCGVAGGATSAAGLGLYGDFAPAAAGLYERPSTAAGRLYQDHGHELHADKSVGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK
The following text describes a protein:
Function:
Required to synthesize hydroxyphenylglycine, a recurring skeletal component of nonproteinogenic macrocyclic peptide antibiotics such as vancomycin. Catalyzes the conversion of p-hydroxyphenylpyruvate to p-hydroxymandelate. The decarboxylation and hydroxylation activities of HmaS show novel and distinct regioselectivity, compared to all other known p-hydroxyphenylpyruvate dioxygenases, by hydroxylating the benzylic position of the substrate instead of the phenyl ring.
Sequence:
MQNFEIDYVEMYVENLEVAAFSWVDKYAFAVAGTSRSADHRSIALRQGQVTLVLTEPTSDRHPAAAYLQTHGDGVADIAMATSDVAAAYEAAVRAGAEAVRAPGQHSEAAVTTATIGGFGDVVHTLIQRDGTSAELPPGFTGSMDVTNHGKGDVDLLGIDHFAICLNAGDLGPTVEYYERALGFRQIFDEHIVVGAQAMNSTVVQSASGAVTLTLIEPDRNADPGQIDEFLKDHQGAGVQHIAFNSNDAVRAVKALSERGVEFLKTPGAYYDLLGERITLQTHSLDDLRATNVLADEDHGGQLFQIFTASTHPRHTIFFEVIERQGAGTFGSSNIKALYEAVELERTGQSEFGAARR
The following text describes a protein:
Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription. May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Belongs to notch signaling pathway and depends on Su(H) for transcriptional activation.
Subcellular Localization:
Nucleus.
Domain:
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG); The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
Sequence:
MVMEMSKTYQYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQTQLLQQQQQQQQHQQQQIPQSSGRLAFPLLGGYGPAAAAAAISYSSFLTSKDELIDVTSVDGNALSETASVSSQESGASEPVWRPW
The following text describes a protein:
Function:
Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.
Subcellular Localization:
Periplasm.
Sequence:
MPRSTWFKALLLLVALWGPAVQADIGWQPLQETIRKSDKDTRQYQAIRLDNDMVVLLVSDPQAVKSLSALVVPVGSLEDPEAHQGLAHYLEHMCLMGSKKYPQADSLAEYLKRHGGSHNASTAPYRTAFYLEVENDALPGAVDRLADAIAAPLLNKKYAERERNAVNAELTMARTRDGMRMAQVSAETINPAHPGSHFSGGNLETLSDKPGNPVQQALIAFHEKYYSSNLMKAVIYSNKPLPELASIAAATYGRVPNKQIKKPEITVPVITEAQKGIIIHYVPALPRKVLRVEFRIDNNSAQFRSKTDELVSYLIGNRSPGTLSDWLQKQGLVEGISADSDPIVNGNSGVFAISATLTDKGLANRDEVVAAIFSYLNMLREKGIDKRYFDELAHVLDLDFRYPSITRDMDYVEWLADTMIRVPVAHTLDAANIADRYDPAAIKNRLAMMTPQNARIWYISPQEPHNKTAYFVDAPYQVDKISEQTFKNWQQKAQGIALSLPELNPYIPDDFTLVKNDKNYVRPELIVDKADLRVVYAPSRYFASEPKADVSVVLRNPQAMDSARNQVLFALNDYLAGMALDQLSNQAAVGGISFSTNANNGLMVTANGYTQRLPQLFLALLEGYFSYDATEEQLAQAKSWYTQMMDSAEKGKAYEQAIMPVQMISQVPYFSRDERRALLPSITLKEVMAYRNALKTGARPEFLVIGNMSEAQATSLAQDVQKQLAANGSAWCRNKDVVVEKKQSVIFEKAGSSTDSALAAVFVPVGYDEYVSAAYSAMLGQIVQPWFYNQLRTEEQLGYAVFAFPMSVGRQWGMGFLLQSNDKQPSYLWQRYQAFFPDAEAKLRAMKPEEFAQIQQAIITQMRQAPQTLGEEASRLSKDFDRGNMRFDSRDKIIAQIKLLTPQKLADFFHQAVVEPQGMAILSQIAGSQNGKAEYVHPTGWKVWDNVSALQQTLPLMSEKNE
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSNFTNAKPQRKYRERAQPTSREFLGILEKHGDYKKRAINYQRKKEQLQKLQLKAALRNKDEFNFRMLKSKVKDGVVYEDQNESSGDEQEILKQIKTQNQNLLKASIQQKEKLTEKLKEDLAMVQFEQPTHKFFLKEARKKSFDQVEDKLQGEAQQSAPNSQLAQKINKLTEALYEKERMKRFYVAITKSKTKDNVTAKPHQRKRIKKGKGKGLFERSR
The following text describes a protein:
Function:
Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes.
Subcellular Localization:
Cytoplasm. Note=Also found in intracellular organelles.
Sequence:
MAAAAAAALESWQAAAPRKRRSAARRPRRREAAPRGREAAPRGREAAPRGPEAEFESDSGVVLRRIWEAEKDLFISDFWSSALETINRCLTKHLEQLKAPVGTLSDIFGNLHLDSLPEESDVATDSIPREILVTGTCHLKCVCYGIGNFATCIVARNQLTFLLLLLEKCQIPRSHCWVYDPLFSQLEIEVLNTLGVTVLSENEEGKRSIRGEPTIFYMLHCGTALYNNLLWSNWSVDALSKMVIIGNSFKGLEERLLARILQKNYPYIAKILKGLEELEFPQTSQYMDIFNDTSVHWFPVQKLEQLSIDIWEFREEPDYQDCEDLEIIRNKREDPSATD
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MFPKNLENVLGKHINSKLKCSYFYTAMASVCRSNTLCLLNLQKFFQHRSDRTRTQVKFLIDYLATRGADFQTSTIEATDTNSCTFSATSCLRLAQTMEQDITTELYSVHEASKLDVDLTKILNRFIVEQTETLSTLQQHLHSLETIRARSSNQGLADYLFDKTL
The following text describes a protein:
Function:
Essential for sperm flagellum biogenesis and male fertility.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Midbody. Note=Localizes to the sperm connecting piece and flagellum during spermiogenesis and to the flagellum in spermatozoa from cauda of the epididymis (By similarity). In sperm cell flagellum, may be associated with tubulin doublets (By similarity).
Sequence:
MEDRSKYIAEESEDEEDEEQEEKEKKGGASTSTETEEDQEDIPSVIVPTINIREERLVDLAQTPAFLCLNELHTSGKLPGTRMAELKAKYTLLHDTVVSTQESEVQLLENAKRFTEQIQQQQVRLQEADDFPNVFTTEVSKLREQLLKYQNEYTAVQEREYHTQYRLNSLTEEKSLVLKEFEKIPKPGEIEKKTKLLKESTEELRKEVIQKRLEIKNLREDVVSKQKQLMKEQKELEELMDYQVGLKDDVVHHQSVPVQITKEIEKLTRRKIETEKKNVVLEFELKELSDSLKKLENKVSALAEERDDTIKEVEGKRTLLEVKEREYGQLLKLLELTKENEASSLAERGILDINLRNCLMDKQNYHDELSRKQREKERDFRNLKKTELLLKVSLDALSQAQALNQRLLLEMEAIPKEDLLLPEQRKELHKEVDLAKRNLAQQRSLSEAEAKLVEQQIAEENKLLKEQETMREVLFNLGRMTQIKMEEKEQKAKDFLKSQRRYCDIIKEIKSKKLEIRLYRKRKREIHRRLKEFAGLYDAIRNERNKFVNLLHKAYQKVNEIKERLKMSLNELEILRSSAVSQERKLQNAMLKHSNNVTIRESMQNDVCKITAKLQEMKEKKEAQLTSMDRLASMITVIEEEMVQLRKKYEKAVQRRNESGVQLIEREEEVCIFYEKMNIQDKVKLHQDIEIHILEEKIRFLKLKVAEKQRQICVTQKLVPIKKSLDANLAVVQIQFSQCADRIKALEKCFVNPDCQGRVRFIPGKDLTEEEMIKKLDMLELQLAKKEEKLLEKDFIYEQVSQLTNRLKTKTQACKMDTLLLAKKMNSYQKKIKDVTQEMMALVAELSMKQALTIELQKEVREKEEFIFSCSSRIEKGLPLNREIEKDWLKVLRDEEMYAFATAEKTREYIDTDYRQLPNGVYTTAEQRPNAYIPETDATLPLPKPYGALAPFKPSEPGANRRHIRKPIIKPIEI
The following text describes a protein:
Function:
Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons. The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1. Also part of an SCF complex required for caspase activation during sperm differentiation. Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in the regulation of zip and ck function in scolopidial apical attachment. May function by acting in a Ubr3-mediated pathway that negatively regulates the ubiquitination of zip, consequently affecting its interaction with ck.
Subcellular Localization:
Cytoplasm. Note=In the spermatid, colocalizes with ntc at the actin-based individualization complex and the cystic bulge.
Sequence:
MNRSGNSQTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA
The following text describes a protein:
Function:
Involved in DNA repair and RecF pathway recombination.
Sequence:
MRSRTANRSGIVIRRRVTPAGDIIVTLLTPQGKLKAIARGGVKGPLSSSLNLFHHVGVQVYQGPHNDLASVKQAVLEGALPTLAEPERYAFAHLMAEFADALFQEGEFSEQAFDLFAASLRGVAHQPDPEWVALVMSYKLLGLAGVIPQTARCARCGAPDPEHPDPLGGQLLCSKCAALPPYPPAVLDFLRHAVRRTVRASFEQPVPSADRPALWRALEKFVTVQVGGVHSWRQLVPSGVPVLS
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MASLPIMAGRFIAITLPAGSILLANTSMADSGNDTIDPSELPIYDVEEASVKYPKRTKSTLETYVSTTRKSVYDITRQLIDITHGVRNSVTSAKERITSTTQDIINKEGLLPRVGLIGFAGLTGFVIAGRRKGIFRRFFYPVGFLTVSSMLCYPVETVNISRSTWRYAKHWYSGDPIDEVQEKNGDSLLSIANSIKTTVNKGLTTLSSSLNSNDNKTASNSENEELEDTAPAVKDSTDNIVNETSETTESLELSKDNLHQDNEENLEVSQTIDDSNKESELEPEPPVDKKETEPKVTGDYGQSSPEDDKKEMKPKIIGDYGQSSPEDSDMYTTR
The following text describes a protein:
Function:
Probable xylan acetyltransferase required for 2-O- and 3-O-monoacetylation of xylosyl residues in xylan. Possesses extremely low activity in vitro.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MVQLPAMKRVKGRAPLSVVVAIIGGLALAGIIFTEDLRGLTEVKEKVTDKEKKRTSLRTVMRTSALLSADQPPPPAVLSVEPATATPPPAPKMAFNATRCSVTDGYWAYDRSKKLPYTDQTCPYVDRQDSCQRNGRPDSDYLYWDWHLDDCLLPRFDPVSMLEKLRGKRIMFVGDSLQLGQWLSFVCLVNSAVPDTPGAKSMERSRTLSVYTVKEYNASIEFYWAPFLVESNSDRNIALGAGGRVLHVDAIEEHGKHWRRADILVFDSYVWWMTGYRIKSVWGSFGDDGYEELDAWVAYRLGLKTWANWVDSNVDPATTRVFFMSISTTHMRSEDWGREGGIRCYNETWPITQRGYRGSGSDRRMMEVMSDVLGRMRTPVTLLNITQLTEHRVDAHVSVYTETGGLLVTDEEKTDPQRYTDCIHWCIPGVPDTWNRLLYAHL
The following text describes a protein:
Function:
Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability. Required for efficient primary cilium formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MSKTSLWQHPYVNVFKHLNIGEWRKSTKEGEVMSVMDKSMKCTVYRITGSIPAGNYIQLPRTSSQSLGLTGRFLYLLFKPIAGKYFVTHVDVTTQDGLVVRLSFSNLFKEFKSTSTWLQFPFVCPAGKGSVERITSKSVRKDLHGPAPSSSKWTLLMLDLQYILSMYLNCKYKYVKSVRLCANMYVKNVFTSDMQYEPDISLQDARDMGLLGQGIAPLPREMTFKVPKGEKWMDHYDYIRFPSAGSKVPFDSVQLNSSGHVTRSTIQVPGHLSPQRVSSKQVCANRDADSLSSMSQSVSAVKQKKKKSTKPAVSMALPEVGVSGDLSILQGTQGEVHVFAQPEDDITVHRHDDNTGMTLSTKISKRSTKPTRDEIYNSLQPDPIISLKKMIGFGGVSTNEILWDHHGNHVVYPCHAVIVAMAVSSGQQRFFIGHTDKVSCLTLSSSGTLLASAQTGQQAVVRVWHYQSGEGLAMFKAHTHSVFTLSFSGNGSTLCGVGKDGHGKNMVVVWNTSRVHRRGDVPVVAKAHTDVDIVRMRVSPYDDTKMVSCGRDNVRVWRVRNGNLRSAPVNLGQVTVAEFTDVCFEAPSTPGMEPADKLVYACTRSGHIFEVDYARVCVAHIRRLLPVGKHVKEKGTFRSGAGIAINALSVNSAFCVTGSEDGVLRIWPLDFKSVFMEAEHEGPVTAVSISPDGLRILAGTVTGNFGVLDVSSRKYTTLMRSHVSSVLAVALDPLRRQMATVSDDHTIRIWDLDTLQQLYDFHAPKETPCTIAYHPSLYCIACGFDNGLVRIFSIASTSLVAELSDLKGKVTGLLYSRDDRHLYSASSLGMLALYDVSDDSYNTIRVLGDMVAKGDVYCPSALSLSPDGRRLAFVGPSEFTVTVADARTLDEVLRIDISSITADRETSGLDMARRVHFSPAKTRQLLVATSENNLLRLDANNGRLINKVSSIHRSGLTGLDVCEDCRHMATAGDKVVKVWDYHMRLDLNFQVFIGHSDVIKQVLFTPDGMNVVSVGDAIFIWDFFGSTQVPSTHSETVTSALKTSRGATPKQPKTFDLNGSLLPRHQVPKPATPTQLTDISSIRERDSERGTYESGEEVLIGPDLESRSEMSSDEEVTLIPETLGSSQRTRSHRRPSPGPSQQGGTNMGGAPQGVFSMETMKSELSSVSKDATSHDRPRCYSHFVAKPNVSQLAQRRYIAPSNQAGLKLKRVLGYNGNGRGNVIWHPDSGLFAYTCGSIIVLEDLDNSSQTHLLGHMEEISVLAFQNDAQILASASGASGLTPSQICFWDLQGAHCRKTLSYHEHGIVGLAYSRDDRFLVSVGDYRDCSIAVWSTQDYSLLAASKTALPVHSLLWDPYTSNEFTSVGEKGTVLFWLLDESQGRVNLNVHEAQVPQELMDHRNMVLDDVAFTSAVYGGDNILYVGSTTGVLSAWDTKHNSCFMHWDADTAEIGVIVSKFGSTRLITGGASRLIRLWSVHGMGELRLTAGFTNSGVGQGLVMEDEMALDGAITSAQFDHTMDVGVVSTAEGTLWYINWVERTSIRLVSSHTAKVTDVAFSESDLFATCCHDGSLNIYSLTDMERSIQFQVLDQSCNCIAFSPRRFGLSSQTPSSSSSMIVAGYHDGTVRLFDLVSCEMTIKMQPHAHSVTAIAFSVDGHVILSGSHNGLIAISSPTTGMTMRVLQDHKGAPITDIQVHQELDTSDPSFHALHKWLAVSGDRRVSVWRASWAKDFCEMVDWLTYPAPAFAPDGTPIEKGDPNRYDSLPPSMARFSASDPNVIIYVGYGMQKQVLFYNLAQKKVIRSAALTHWSTSFDLNPRGHLIAIATQERLVKVMDYQECSFQDFVAHSDAVELVRFSGDGEQLFSVSGTEILLWDVAV
The following text describes a protein:
Function:
Assembles with the minor capsid protein to form an icosahedral capsid with a T=7 symmetry, about 60 nm in diameter, and consisting of 415 capsid proteins. The major and minor capsid proteins are incorporated into the capsid in about a 90/10 ratio respectively. Once the capsid is formed, encapsidates one single copy of the viral genome.
Miscellaneous:
MISCELLANEOUS: [Isoform VC10A]: Produced by conventional translation.
Subcellular Localization:
Virion.
Domain:
The N-terminus interacts with an internal region of the major capsid protein subunit in an adjacent capsomere (intercapsomeric interactions) to stabilize the capsid.
Sequence:
MASMTGGQQMGTNQGKGVVAAGDKLALFLKVFGGEVLTAFARTSVTTSRHMVRSISSGKSAQFPVLGRTQAAYLAPGENLDDKRKDIKHTEKVITIDGLLTADVLIYDIEDAMNHYDVRSEYTSQLGESLAMAADGAVLAEIAGLCNVESKYNENIEGLGTATVIETTQNKAALTDQVALGKEIIAALTKARAALTKNYVPAADRVFYCDPDSYSAILAALMPNAANYAALIDPEKGSIRNVMGFEVVEVPHLTAGGAGTAREGTTGQKHVFPANKGEGNVKVAKDNVIGLFMHRSAVGTVKLRDLALERARRANFQADQIIAKYAMGHGGLRPEAAGAVVFKVE
The following text describes a protein:
Function:
Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
Subcellular Localization:
Mitochondrion.
Sequence:
MRIRIRNIEQVNQHLRNAYLCSTQPSVAPKVVVVPQSTIVDKGESSRYWVDPTNHMRLPRSLAAALYQTQNTQSKRSIGNMEKPSFQPKKVLILSKLTRYEFEKKVHKGCDDDQLASILKKRGSDYQRLLSKHKIHHSYLNTLQKELENAGIESRLVRRFGYTQEAVDWADAVFSAGGDGTFLMASSKVRTKHKPVIGINTDPQGSEGYMCLMRKLPEENLSGALKKLFSGNFEWLYRQRIRITVTGDDGISDAIELHDQQLNRDPATTRWTDNPRSPARENDVEECMSLSPPVKKRMISESEDKAIVPIEKETVELPVLALNEVFVGESLSSRVSYYEIGLNDEQMLKQKSSGITICTGTGSTSWHFNINKLTEQCVQDLMKIVAQHCNLPQIPHENKNAVSEICTKFNQQLIFDPDRRQLAFSVRDPIFNATFPPTDPRGFADKIRIKSRGYDAHLVIDGGISYRFNDGSEAVMEVRDEDTLRTVVFR
The following text describes a protein:
Function:
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
Subcellular Localization:
Cell projection, podosome. Cytoplasm.
Sequence:
MAASRAPQLPEKSWALSLGSLLPSGRGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSGADANAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPARKKNLAGPVEIIGNIMEISNLLNKKTSGDKETPPAEGEGPEAPITKKEISLPILCNASNGSALGVPERTVSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEAPASTNESQDSPLKLKYEEPEYDIPAFGFDSEPELSEEPTEDSGSGDRRPAQPHRPSPASSLQRARFRVGGSSEDVALEEETIYENEGFRPCAEDALSVRRSSRDSDSPGSSPLSLARKNSPKSGSPKSSSLLKLKAEKNTQAELGKNHSSASFSSSITINTTCSSSSSSSSLSKNSGDLKPRSASDAGIRGTPKVGAKKDADLKAGLTSCARAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAFEGPNEGSRRSSADLITLPATTPTKKGREGQATSYTTCSAYQKVQDSEISFPAGVEVQVLEKLESGWWYVRFGELEGWAPSHYLVLGENEQPDLSGKEPDAVTTKNKQNEGKSDSLEKIEKRVQALNTVNQNKRATPPIPSKPPGGFSKTSGAGVVKMRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERATSQGSDAPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN
The following text describes a protein:
Function:
RNA-binding protein involved in post-transcriptional regulation. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Localizes to multiple discrete foci in the cytoplasm.
Sequence:
MFTAVNSNPNASESISGNSAFNFPSAPVSSLDTNNYGQRRPSLLSGTSPTSSFFNSSMISSNYTFPHGSNKQASLESPVSYSNPIPSLTWLSLDGDSPDSLVSTPTAPSANHHGNPFPNGKQSIKAMPSLVNLQEDSVISKFPNSLEVPFRKRSESTSSSLSGLHSDLRPLKTELYGQLNSECGARFPQTLKSPLTPIGGDSARTVSASTARTSDKFFPRHTRAHSDFWIPATSKPSRHASHSSIGDLTTITQSSISSGSGSFKPSWDGSFDSSLMAHQSYGTSPAFANGNSPTLKNDSSFFGSASVRPTVSPIGTSFRQSLPDISAFGIPKTETNPSEVVAPGTIPISVLPTSNFSAATPANPSLINQNGQEFLQQSRVLYLFHANKQRHFELSDILGNVVLFSTDQHGSRFIQQKLATATEEEREAVFQEIASTSCLQLMMDIFGNYVVQKYFEFGNEKQKQILLSQIKGHVFSLSLQMYGCRVVQKAIEYISPEHQVQLIQELDGHVLDCVCDQNGNHVIQKAIECIDTGHLQFILRALRPQIHVLSAHPYGCRVIQRAIEHCHSERKLIIEELLPHILKLTQDQYGNYVVQHILRTGSESDKKYIFDLMIDHLLFLSCHKFASNVVERCISYISDVDRRRILNKIISEKAENCSILMLMMKDKYANYVIQKLLDASPEEERDLLISYIYPHISVLKKFTYGKHLIMSVERFRQKSISAVPKLASKECK