lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MSHQTGILATDELREFFAACKEGGANEGRYRAIKVSIENETLVLSDSGLADGTFEDDWDTLVLPMLEEKQPCYIFYRLDSRESHGGFEWLFLAYSPDHAHIREKMTYAATRATLKKEFGQSQIKEEVFGTTPEDISLAGYHKHLQAQNAPAPLTEAEEELKYIKQQELQMSCIQDSRFSYYNREMPPPVAPRPRMRGVSTHIHVETRQQTVQGVAFPIAQAAMAKLQQLKLGQIDYVRLELDMDRETIELSGAEDTTVQSLPQRVPEDHPRYHFFVFKHTHEGDYQESVVFIYSMPGYKCSIKERMLYSSCKAPLLDQTEHSIGITVSKKVEIDDGAELTEEFLMDELHPKKNAYREKFARPQGPAGKRGPRRMIRGANTPSS
The following text describes a protein:
Function:
Required for mitotic division of the generative cell nucleus and the development of mature tricellular pollen grains, and for male and female meiosis.
Miscellaneous:
MISCELLANEOUS: The induction by X-rays is dependent on DNA damage signaling by ATM.
Subcellular Localization:
Nucleus.
Sequence:
MDYGDDDRSSSWNWQVDNYNHQPQSHFSDVPDCTMTEVTLNQEDHSYMFDDENTPVKACSELGYHVTTEDTNRKMEVHSETRSALKRRRMLQFEDQPETSLFSSESFSAILKSSARDDTFDELLPEGSQLIEGFSEDASASSFEGLDLYAEEWYADCLNDAETPMLPDDLNFGSPDVQVDISEYLNVPPETETREVQRPVTRSSPNVIFKGRKSFSRPVSKLPSSIIYPFAFIKPCGVHGGMTLKDINQKIRNPPAKPKAHIEEPAVIQTSAFSGKPVVGKTKIRTEGGKGSITIMRTRG
The following text describes a protein:
Function:
Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.
Subcellular Localization:
Cytoplasm, perinuclear region. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity).
Sequence:
MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSMEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMETQSQGAV
The following text describes a protein:
Function:
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Sequence:
MKLNGEEEEEKVVVGYALTSKKKKSFLKPNFIALARNKGIFFVAIDLNKPMLEQGPFDVVLHKLPGKEWREIIEDYRHKHPEVTILDPPDAIQHLLNRQSMLQNVAELNLSDCHGKVGVPQQLVITKNASASTIPYEVTKAGMKLPLVAKPLVVDGSAKSHELCIAYDELSLLKLEPPLVLQEFVNHGGLLFKIYIVGETIKVVRRFSLPNVGKHELLDVDGLFRFPRVSCAAASADEADLDPNIAEHPPKPLLERLARDLRRRLGLHLFNIDMIREHGTKDVFYVIDINYFPGYGKMPEYEQIFIDFLLSLVKNKVLSSFSLYSSLQPNFYTRSVLKLRLGRSDRLDREPVVYPVRAVYQIVHTIEPVKTGLAR
The following text describes a protein:
Function:
Specifier protein that contributes to constitutive and herbivore-induced simple nitrile formation. Promotes simple nitriles, but not epithionitrile or thiocyanate formation. Converts allylglucosinolate (allyl-GSL), 2-propenylglucosinolate (sinigrin), indol-3-ylmethylglucosinolate (glucobrassicin), benzylisothiocyanate and benzylglucosinolate (glucotropaeolin) to their corresponding simple nitriles in the presence of myrosinase. Catalyzes mainly the conversion of benzylisothiocyanate when benzylglucosinolate is used as the initial substrate of myrosinase.
Miscellaneous:
MISCELLANEOUS: The proton donor differs depending on substrates; MISCELLANEOUS: Does not contain the mannose-binding lectin domain present in other members of the family.
Sequence:
MCPVENKWLKVGQKGAGPGARSSHAMTVVGNKVYCFGGELKPTIHIDNDLYVFDLETQEWSIAPATGEAPFPCFGVSMVTIGSTIYVYGGRDDKRRYNGLHSYDTETNEWKLLAPVEEGLPGRSYHSMAGDDRKVYVFGGVTAKGRVNTLHAYDVVDQKWVEYPAAGEACKGRGAPGLVVVEGRIWVLFGFDGNELGDIHCFDLASEQWKAVETTGDVPAARSVFPAVSYGKYIVIYGGEEEPHELMHMGAGKMSGEVYQLDTETLVWERIVCGNEEEKPSQRGWCAFTKAVKDGEEGLLVHGGNSPTNERLDDLVFWGFSHLNVN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MASKKALFKEGCAPPSLRLHFQAVREPRLKMEEKNPMCAKSSEGAKKVPRGVQADSAKEILRLMTPEQIKQEPDEGLAQRWETQWQEFLKVVQSPHAGWGNPELVAFNSPKGLHISGKTAQSPALAWKVKEEALEEEAAGPETQRQRFRHFCYQEAEGPREVCSRLRELCHRWLKPERHTKEQILELLILEQFLAILPPEIQGCVRERGPETCAQAVALAEGFLLRQQEAERPRQLILDSFKEMAVNFPRAQQACLGASRKQAGSRLLNDPERHVLGHQEYLEREPPGRMLLSKPRENLSQHRDLSKPSENQSRVERPQGIHPSKRAPEPMPCRVDYANLGEILFQGRMPEGQRPKRCVVLRRRIHSEERLYKCQDCRKSFDHRSHFIRHKKIHTGEKPFQCADCGKSFNRNSNLTTHMRTHTGEKPYTCADCGKSFRWSSDFIVHERTHTGEKPYSCADCGKAFRRSSNLTAHERTHRGEKPYKCLDCGKSFTRGLYLVAHKKTHIMGE
The following text describes a protein:
Function:
Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLFRARGPVRGRGWGRPAEAPRRGRSPPWSPAWICCWALAGCQAAWAGDLPSSSSRPLPPCQEKDYHFEYTECDSSGSRWRVAIPNSAVDCSGLPDPVRGKECTFSCASGEYLEMKNQVCSKCGEGTYSLGSGIKFDEWDELPAGFSNIATFMDTVVGPSDSRPDGCNNSSWIPRGNYIESNRDDCTVSLIYAVHLKKSGYVFFEYQYVDNNIFFEFFIQNDQCQEMDTTTDKWVKLTDNGEWGSHSVMLKSGTNILYWRTTGILMGSKAVKPVLVKNITIEGVAYTSECFPCKPGTFSNKPGSFNCQVCPRNTYSEKGAKECIRCKDDSQFSEEGSSECTERPPCTTKDYFQIHTPCDEEGKTQIMYKWIEPKICREDLTDAIRLPPSGEKKDCPPCNPGFYNNGSSSCHPCPPGTFSDGTKECRPCPAGTEPALGFEYKWWNVLPGNMKTSCFNVGNSKCDGMNGWEVAGDHIQSGAGGSDNDYLILNLHIPGFKPPTSMTGATGSELGRITFVFETLCSADCVLYFMVDINRKSTNVVESWGGTKEKQAYTHIIFKNATFTFTWAFQRTNQGQDNRRFINDMVKIYSITATNAVDGVASSCRACALGSEQSGSSCVPCPPGHYIEKETNQCKECPPDTYLSIHQVYGKEACIPCGPGSKNNQDHSVCYSDCFFYHEKENQSLHYDFSNLSSVGSLMNGPSFTSKGTKYFHFFNISLCGHEGKKMALCTNNITDFTVKEIVAGSDDYTNLVGAFVCQSTIIPSESKGFRAALSSQSIILADTFIGVTVETTLKNINIKEDMFPVPTSQIPDVHFFYKSSTATTSCINGRSTAVKMRCNPTKSGAGVISVPSKCPAGTCDGCTFYFLWESAEACPLCTEHDFHEIEGACKRGFQETLYVWNEPKWCIKGISLPEKKLATCETVDFWLKVGAGVGAFTAVLLVALTCYFWKKNQKLEYKYSKLVMTTNSKECELPAADSCAIMEGEDNEEEVVYSNKQSLLGKLKSLATKEKEDHFESVQLKTSRSPNI
The following text describes a protein:
Function:
Essential for phagosome maturation and the innate immune response to bacteria. During phagosome maturation it is required for the fusion of late endosomes/lysosomes and phagosomes. Not required for autophagic flux.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic vesicle, autophagosome.
Sequence:
MDLQLDSESYWNRSSRAAFSFDDEDEVDLAPDLVSNGILADDTISEASFNNSVALNLSIKSILSEEALKLVLQEQALDDRVLPKGVSPEEELKLLRRQLQSTLYSPNLEATAQKLLQGKTAPLEMFKSLHEKQQLLDTLMAQGGGHAVITVLLFLKRTLNTTQFHGILRERPKALEQYLSYLKESGDLAGHIELLQLFGRHQEAALKQFQAALASGDTSTRKKHLQLLVDAYATAGVGVIPLYEQVFHAALKMQQLMEKDSALGKLLRDQPTPVEVLYACCQVNSNWKEQDMLKPVSPQRFAADQQISPAQYEWTALNERAQAQAYADLECIFERVPSWHPLKTKQFHISFDLTLAVLRLYELQAPSTVLQLFLSKMGNSVEKLALAQRVKCIKAVIDAMAGLKQQQELQQLKDTLPERSEEQFYCENALKSLQSKRWTTDNIKLKL
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MRAEESERRCRQLTLLQSRLREIVAEEEEMSNAVSGVIDARWMRFLRECKQRELVAEIEVLRRTFEATLDRKKGFSTTLLEELSVAEEQCRHAFRSHMDVVSSLLQLHAARTKDLEADLDANVAEMQQDFEYERAELELKHMIEMDDLRLILDNMAAEAEMLEKKLQEETSEGHETAAEKMDEAMREMEADLNKVEDGLRGELDSRYKKFMSAAQANMKEYTAKCKEDQETTERIAAQLRKIEKLQSSVSSWRTNIARNAKEWEDRNAAIQAERDATLSHLKKLKDKMQRWRELQSKALVELVKEANATEEALQATSKRAVRLLRLVELCKPMETEREQVLLHEANISSAAVEAETKRRVAAESSGNAQDDVLRGGDAAPAANEQWLSLDRFWVKHNKVVLDNAALTQERFLLEEENRVLQEVLKQYLDDVSISDQVMRQSNTLLLTQGANYNVVQAANASDNSVVRGYNVIEGNKFVNDQSRQAISH
The following text describes a protein:
Function:
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MAWLTLYLLSVLWAVAGTSTRAQSSCSVPPDQQPWVDGLQALMENSVTDSDFPNPSILIAMNLAGAYNVEAQKLLTYQLMASDSADLTSGQLALTVMALTSSCRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKKWDCEKTMHTILNEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSVSNITVIYTINNQLRGVDLLFNVTIEVSVKSGSVLLAVLEEAQRKNSMFKFETTMTSWGLIVSSINNIAENVNHKTYWEFLSGKTPLDEGVAYYIPFNHEHITANFTQY
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MKISIQQVSTYSGFCLSVLVNNILMYMIKNKTTKQLGSYVYLMLSFSVFELLFSTVDVLNQPMIFVNNGEFIFFSSNPLHLNKAVAKHFNMINFACSGIIISLLAIHFFYRYMAVCNNQTWLKQFEKPRFLIWILIFFIFGLEWYFATLFLGNTTDKTCEVDMDALIDYYKVDPELTVFIGIKYHVKSALKTTFCTKSIILALILLKIVLISCIIVVYCGFRTWKEITIKKRIVSRRTLDMQRQFFRALVVQTLIPFFLLYLPLITMLCAPILMASLHKIDILIQFAFVFYPILDPIAVLMIVRDYRRAIKSFFVDQLFERTVRILRCCLPWLASENRTITPPPAHVNASGFPRYIY
The following text describes a protein:
Function:
Dual-specificity kinase with both serine/threonine and tyrosine kinase activities. Required for postmeiotic development of microspores (Ref.2). Involved in embryo sac development at the late stages of megagametogenesis (Ref.3). Involved in the phosphorylation of KIP1.
Subcellular Localization:
Microsome membrane; Single-pass membrane protein. Cytoplasm.
Sequence:
MMTEVHDAGRPRVVIFNGSQLQREAIIPFASRSSCFHHQLCSRGHLLIIFLLLVSPFNDAAVDVDGDDNDNLIIDHVPDAKSSSEALLNFKSSLSTSSPRGHEVLGSWIPSNSPCSGNNGNWLGVLCYEGDVWGLQLENLDLSGVIDIDSLLPLHFLRTLSFMNNSFKGQCLIGISLEPSSHCTCPIIASPVRSRMMLPGYDLSQEALFGKQPIQRQHPHLPGYLLPQVFELSLENNRFTGSIPHFPPNVLKVLNLSNNQLEGPIPPALSLMDPTTFSGNKGLCGKPLESACNSPSQEANNPDSRNSSTISGQSSTDVIRKSPTRLSKVMLIVAVCLVVLCLLIVLILIIRRRSHSSSQNPQPVESNYSNNDRDQNAFTSSAPDDHVTLSGNSTYSNNQHSNSNKAEAPTAAVVGKLSFVRDDRPRFDLQDLLRASAEVLGSGNLGSSYKALLMDGQAVVVKRFKQMNHVAKEDFHEHMRRLGRLTHPNLLPLVAYYYRKEEKLLVYDYASNGSLASHLHGNQSRLDWSSRLKIVKGVAKALAYLHNELPSLALPHGHLKSSNVLLDKYLNPVLMDYTLVPLVNLAQVQHLLVAYKAPEYAQQGRITRKTDVWSLGILILETLTGKFPTNYLALSTGYGTELATWVDTIIRDNESAFDKEMNTTKDSQGQIRKLFDIGVACCQEDLDTRWDLKEVVQSIQSLNDKDHGHSNSDQMHDAGV
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MYAAISEMEKILKVENEVARDLREYVQNEEGRLELLKGLADEFEEHSRKALANPEGHLSNPLNAYLLIKRFTSEWQYVLEEKIKKSFADDFLRRLDEKTANFPTSEDLHGAINALMRLQDVYDLSTSELADNGIDGTPGASKLSFEDCKLLGLSAYEKKDFYHTILWMTEAMRQLIKSPLEEPKFQIQRIDILDYLAFSYYQQGNIKKAINLTLDYLQLDPSNTRIQSNLRHYQQLLEQHRDLLSSSSSSGGPVADYDDDYNPRPHTDNRIRSDEFYNYERLCRGEKIMPIENEHLLTCQLKSHHPALYLRPAKEEQVNYDPPMFMYHDLLVDDQMETIKRLGRPRLYRSVVFQKEGMESPDFTAQDYRISKTGWISDKEHPHVLGFSTIASAIANLTLDYAEELQVLNYGIGGHYEPHFDYSSNPEPSEFEKVRGNRIATFLCYMSDIKIGGSTVFPQVGVKFTPKKGSCALWYNLHKSGVGDRLTSHAACPVLSGIKWATNKWFRERGQEFIRPCTLSPMD
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MDDFELDSDLRFIQHTYSAYRDIIAHWQTKTSSCKEKLNALAKLLDLKNYKSETIIGIIQKIMETFELSVNSQEFSCFYNFVFFICRENGQKSVPVNMAIDAWRIVLSGRFRLLSHWCDYIKKTQRHNISEDTWHQVLIFSRCINENLDDYDPEGAWPVLIDEFVDHMYSKYRTCLPSTSRDLYSCIDGEMQPDISSMRGGLKLLPGSKRKSMTTYEMEEISYTDKSLSLTDISPSDTIMHTVVSNNQRQMRKVYSFGSGKPIKSFCR
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MIRRSTFSAPARLIALMLVMAFVVTGCHRGAKDKNPDEGMPVEQLYGKGHGLMEKGNWAGAEASYKRLIAQYPYGPYTEQAMIETAYAQYKAGKHDDTVSSVDRFIRTYPTHRNISYLYYLRGLANSNRDTVFLRRVWSLDPSRRDLSSPQQAYNDFNTVTDRYPNSRYAPDARKRMIELRDIFAQHELDNALYYLRRDAWVSAAGRANYLLETYPQSAFQYDAVAVLAEAYTHLGNKTLAADARRVLELNSPQHPWLTGDWPKYPWAVRKLNPFAGEKSAATGQRNAQMSRD
The following text describes a protein:
Function:
May have a photoreceptor function.
Sequence:
MLGPDYSTKFSPWLASGSLSPRFIYEEVKRYEKERQSNDSTYWVLFELIWRDYFRFLSIKQGNLLFHAGGPRKVDINWSQDQTMFDAWRRGQTGYPLIDANMKELATTGFMSNRGRQIVCSFLIRDMGIDWRMGAEWFETCLLDYDPCSNYGNWTYGAGVGNDPREDRYFSIPKQAQNYDPEGEFVAYWLPELRALPREKRHSPGMMYLKPIVALKHGYTKKTGDSKVAFSSRRAKPEDNRRKGHGDRRMY
The following text describes a protein:
Function:
Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MALRLVTHFDVLEDVLPSLLTQAATTDEGDRAGVLETTYGSLRVLNIERNGNIIYTYKDNKGNAVFGLYDCQTRQNEHLYTFEKDMQAVSCSVNSERTVLAASFIQYTTEGVKNDLQPGSKCLTLLVEIHPVNNVKVLKAVDSCVWVQFLYPQAESHLLPQNHLLLISEEKYIERFHIQITREDGDRVVIRNSSHLPRDRLAEDFVWAQWDLSEQRLYYIELKESRSILKCIQFRADESFNLMFEMPLDITLTGLRFKLVNFGYDYRQDREKLCNQPSLCIFTNHTGSLCMCYSPKSDSREEITYSVFYLHKGYRKIFTAAPGSADSQVTNGADSQVTDGIAFLNLGYFVAVYSPGHFLHLLNIQHPDLVCHSLFLTGNNKIAAVLPPSPLQSLPGSLVLDCYSGKVYRVTLDQSYLLRFLWNAHLDCERMAALHCILSCSQDPGFPEEQIIQWISEHVSACHSFDLIQEFLIASSYWSVYAELDDMGMLLQYSSVLTWNTEIPGIKFTTEELPLPLMKVYGLKGYWAKLNSNLEYIKYTKPHLHYHNSVVRREWHNLISEERTGKRRSTMYVRNILENAMKVIASMETRTLEPRLIPFLQEEDRHQRLLMGLMVSELRDHLLRHLQGVEKKKIEQMVLDYISKLLDLIWCLLETSWRKHSMHPLVLHLNSHCSAADFEVFHLMTRILDAASSLCLPLPPGFHSLHTILGVHCLPLYSLLHYIDNGVLLLTETAVTRLMKDLDNSEKNEQLKFSIIVRLPPLIGQKVCRLWDHPMSSNIISRNHVARLLKNYRKEPRNSMIDKSSFPVEFLPLNYFIEILMGLESSNQALYGFEGHDNVDAEFVEEAALKHTTMLLGL
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MTGTPLIEVEDLRIDLDDGSRRVAAAEGISFRIDRGETFGLVGESGCGKSITALALIGLLRPPLSIGGGAIRFEGREIQHLSAARQRELRGNRIAMIFQEPMTALNPVSPVGRQIAEMFVLHQGKSWREADRLAVEALASVRVPAPERRVKDYPHQLSGGMRQRVMIAIALACGPDLLIADEPTTALDVTVQAEIIELMRNLCAERGTAILMISHDLGLVANVCRRVAVMYAGRIVEERGSADIFRAPSHPYTQGLVDSLPRLGSRAALGRTRLQEIAGVVPAITAFPDGCRFNPRCARATDICRTAAPETTRLDAGGLVRCHHHA
The following text describes a protein:
Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Sequence:
MVLGSGGLLLLLAMLGVSCRVLHPEMSPTGCGQPQVPNAEGRVVGGHAAQAGAWPWQASLRLRKVHVCGGALLSPQWVLTAAHCFSESLNSSDYQVHLGQLTITLSPHFSTVRQIHLYSGHPGAPGSSGDIALLQLSTPVTLSSRVLPICLPEASADFPPGTPCWVTGWGYTREGEPLQSPYILQEAEVSIVDTETCSRDYSGAGASPIRPDMLCARGPGDACQDDSGGPLVCQVGGIWLQAGVVSWGEGCGRPDRPGVYTRVPAYVSWIHGYILASGASGPVRPQLTGPPLVFLAGFFLPGLLLLLVSCVLVAQCSLHRAWVSSPSHPACDR
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Acts as a reactive oxygen species (ROS) scavenger in the cytosol. Possesses superoxide anion and hydroxyl radical scavenging activities in vitro. Plays a role during root development, lateral root initiation and seed embryo germination, possibly by regulating levels of cytokinin.
Miscellaneous:
MISCELLANEOUS: Down-regulation by RAC1 during pathogen infection may potentiate ROS which function as signals in resistance response. Plants silencing MT2C show abnormal plant growth and root formation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSCCGGNCGCGSGCQCGGGCGGCKMFPDVEATATTKTFVLAAPSNKASSGGMEMAVESGENGGCGCNTCKCGTSCSGCSCCSCN
The following text describes a protein:
Function:
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity).
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Cell projection, dendrite.
Domain:
The extracellular domain contributes to synaptic contact formation; The GABA-binding pockets are located at the interface between neighboring alpha and beta subunits; GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Sequence:
MRTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNSMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNPSDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
The following text describes a protein:
Function:
Essential protein required for cell fate determination during embryogenesis. Involved in sister chromatid cohesion during meiosis and mitosis. Forms a complex with SCC4, which is required for the association of the cohesin complex with chromosomes. Plays a structural role in chromatin, especially in centromere organization, chromosomal axis formation, and distribution of the cohesin subunit SCC3 on chromosomes.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Associates with chromatin.
Sequence:
MSNPSSSGLGSSSGLTHFGIGLANTVQSEVTPYLPLPSLPIFCGAAEPGEFKLFDEVGQGSGYRSLDRSEILAQSSRIANMLHETDVSYLDLRNEARAPDCNSGEHFQLYDLVLRCNPGAFEYVTPGPTCDPLFTNEGPQKIISEPSVPVKMQRQTDTHLARSIEPEPVKRVLRPNHVEDHSWQHETLTNQSPKDVTAYDSRPETITMNELSASKKPKGKKKRKDDLSSVQPDPSVLQESIVQNFCEMLEDFCGRAEVPGDDRDEAEWSSVPVDEVRVLINELMTIRSKMLLHMVPVDILSRLLRTLDHQIHRAEGLSIYSEHSDSDSVLLVLGALESIHASLAVMANSDMPKQLYKEEIIERILEFSRHQMMAVMSAYDPSYRTGSKPAENLAFEGDDDDDNPDHDMGSASKRRRIVKNSKVKKASVNRISGAVNTALQKLCTILGLLKDLLLVERLSDSCILQLLKTSITTFLVENIQILQLKAISLIGGIYNSYSQHRTYVIDEISQLLWKLPSSKRALRAYLLPDEEQRQIQMVTALLIQLVHNSTSLPETSRQAASGNSILETSVDVGYLTKCHEAATETCCLFWTRVLERFTSFKGQDASEIKLIIENLVMDLLTALNLPEYPSVSPILEVLCVILLHNAGLKSKDVSARIMAIELLGTIAARLKRDAVLCSKDRFWTLLESDSEISVDQVCTKDCTFCLGKRAGNLLVCQICQRRFHGDCLGLKELDISSRNWHCPLCVCKRQLLVLQSYCKTDTKGTGKLESEESIENPSMITKTEVVQQMLLNYLQDVGSADDVHTFICWFYLCLWYKDVPKSQNKFKYYIARLKAKSIIRNSGATTSFLTRDAIKQITLALGMNSSFSRGFDKILNMLLASLRENAPNIRAKALRAVSIIVEADPEVLCDKRVQLAVEGRFCDSAISVREAALELVGRHIASHPDVGIKYFEKVAERIKDTGVSVRKRAIKIIRDMCTSNPNFSEFTSACAEILSRISDDESSVQDLVCKTFYEFWFEEPPGHHTQFASDASSIPLELEKKTKQMVGLLSRTPNQQLLVTIIKRALALDFFPQAAKAAGINPVALASVRRRCELMCKCLLEKILQVEEMSREEGEVQVLPYVLVLHAFCLVDPGLCTPASDPTKFVITLQPYLKSQADSRTGAQLLESIIFIIDSVLPLIRKLPLSVTEDLEQDLKHMIVRHSFLTVVHACVRCLCSVSKLAGKGVSIVEHLLQFFFKRLEAQGSDNTQIAGRSLFCLGLLIRHGNSLISTSGGKNFNLSGCLNLFKRHLRTEDIALKVRSLQALGFILIARPEYMLEEDIGKIIETTLADEANGRMKMQALQNMYEYLLDAEKQLGSEKASDNTVNSVEQGGHNVPVAAGAGDTNICGGIVQLFWDKILGRCLDFDDQIRQTSLKIVEVVLRQGLVHPITCVPYLIALETDPQEANQKLAHHLLMNMHEKYPAFFESRLGDGLQMSFIFMQSISQVTSEPNQSLQQKGSTNMLGKNDHASSTLTQARLGVSRIYKLIRGNRVSRNKFMTSIVRKFDNPTWNGSVISFLKYCTETLALLPFTSPDEPLYLVYSINRVMQIRAGAVESNLKALLHKDSAKTQHGNGAYQQDPIPGHMNMMDLNTRIQEEPRHWNSYGHATLIDLNGSVYQDSRDQFTSYQVHNGKADVHKMTSSDPPELSTDDLQKIQVDCLAAIAIQLLLKLKRYLKVTYSLNDDRCQAYSPTEPLKPGDPLSRQSVAFDLSETRTDLPSTYQDLVQRYQEFKNAMREDTVDFTIYSTNVKRKRPTPRKTSRSAKKTVAYNEDDDDDDNDDRGWHGGGGRGAARRLNYSTRSSNRR
The following text describes a protein:
Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Also cleaves 5' phosphotyrosyl adducts resulting from dead-end complexes between DNA and the active site tyrosine of topoisomerase II. Contributes to DNA repair after radiation damage. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 2130 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSRETNFNGTKRKRSDVAEKVAQRWKSVRYSAEMENMAPVNSNNDSDDCVIVSESKIIDLTNQEQDLSERIETNDTAKGAVFKLMKSDFYEREDFMGEVEDMITLKDIFGTETLKRSILFSFQYELDFLLRQFHQNVENITIVGQKGTIMPIEARAMDATLAVILKKVKLIEITMPPFASHHTKLIINFYDNGECKIFLPSNNFTSMETNLPQQVCWCSPLLKIGKEGLPVPFKRSLIEYLNSYHLKDIDELITKSVEEVNFAPLSELEFVYSTPSKFQSSGLLSFYNKLEKLSAGTSASDTAKHYLCQTSSIGTSLSRARDENLWTHLMIPLFTGIMSPPAKDTAGRKKAEILPTNSLINEYSQRKIKPYIIFPTEQEFVTSPLKWSSSGWFHFQYLQKKSYYEMLRNKFKVFYKQDPAMVTRRRGTTPAHSKFYMHCATNSAGPCDASQVFKELEWCLYTSANLSQTAWGTVSRKPRNYEAGVLYHSRRLANTRKVTCRTFTRDRRGCAGNPTHVAVPFTLPVIPYDLAEDECFCLARHEND
The following text describes a protein:
Function:
Involved in nacre formation. Affects morphology of calcite crystals in vitro but does not inhibit their formation. Binds chitin.
Subcellular Localization:
Secreted.
Sequence:
IPDLASSRSTLPVLTKGPTGLLGPRGPYGPLQRFNIELSARGPAAVVGVLGKSFDSWLTKLGLPGPQGRPGPPGPGCRFALSNQCIKLAVEFAGQSKFSSFLANEGKKEGPEGEEGPRTEFDGAYFAGGKFPVVGKPFPQLKVFHAEPPFPTSRSTYGPSGSQPGKKGVVTPFKGNQPLKFNDFLVESDSRCPPDDSSFERSPAVSGHSSPATLNSRMKPAGFPGKGNGAPLKNGIASDPLENLKNRLGSCFPDVLDEPPTSPFFTGPSGYTSDGLNKTPTVSKTLTAAGDPGPGAGKVLESSKTDLVALQGEFQR