lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPASKKAVQGGAAAPVVGAVQGPVPGMPPMTQTPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
The following text describes a protein:
Function:
Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the localization to the nucleolus of Cdk7, a regulator of the Pol I-elongation factor TFIIH. Acts as a regulator of cell proliferation and tissue growth as part of the TORC1 and Myc signaling pathway in response to nutrients. Required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts. Not required for female germline stem cell (GSC) maintenance, but necessary to regulate germ cell differentiation and egg chamber development. In female somatic cells, required for follicle stem cell survival and maintenance.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Chromosome. Nucleus, nucleoplasm. Note=Co-localizes with active forms of RNA polymerase II. Associates with open chromatin and chromosomal puffs of polytene chromosomes in larval salivary glands. Nucleolar localization is controlled by mTORC1 signaling.
Sequence:
MAEEGPPEPSIDFVPALCFVPRGVAKDRPDKIVLTQAELARIIGDTQQELDEESDDDAEEGENAEEDQNDMDVDDHADANSENRDPQDEFQFQEYDNEANANVTSLANIVDAGEQIPDEDEDSEAEDEVIKPSDNLILVGHVQDDAASMEVWVFNQEEEALYTHHDFLLPSFPLCIEWMNHDAGSEKAGNMCAIGCMDPIITVWDLDIQDAIEPTFKLGSKGSRKQNKEQYGHKDAVLDLSWNTNFEHILASGSVDQTVILWDMDEGQPHTTITAFGKQIQSLEFHPQEAQSILTGCADGYVRLFDCRDAEGVNSSSIEWKVDGEVEKVLWHPTQTDYFIVGTNDGTLHYADKRSPGQLLWSVKAHNEEISGVCFNNQKPNLLTSTSTEGTLKVWNFDGTEAKHVYEHEFNMGRLQCMRQCPEDPYTLAFGGEKPPRCAIFNIKNSIAVRRTFGIPDAE
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MPRNMKISLLLIVAACLSTLLILRKTTSDERPSQAQLNHRPNAFMRDVNYYQYDEGGLLHSHLVSPLITHFPYQNSFQFTRPHYLIYTDKRIPWNITANSGKSQQGIKRIYLWDHVKVHEPPQPTEPETTITTSTLTLFPERSFAKTNDPVTITRPNAVIKATGMTSNLKKGLVHLLSHSRGVYEVEPAPGKKNS
The following text describes a protein:
Function:
[Ala3,Thr6]bradykinin: produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. Possesses insulin-releasing activity. May target bradykinin receptors (BDKRB).
Subcellular Localization:
Secreted.
Sequence:
MRLWFCLSFLIILCVEHFPGTLAVERNVPESEEKTEQFLRDLFEISRLQRRPAGFTPFRGKFHSQSLRGLSETKRIYNAIWPCKHCNKCKPGLLCKK
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVQAAGIFAVRKTVSCCKCGITMVSNASNMCVTCLKSEVDITESLQKHANITPCPKIKLKLTVQKEVLEGVIVEQSDVVMSRNITCVNLVPGFMQTGPDHWDAAVQLELIQKHDAPARATKIKKMDHGIEFFFSGRSHAVKFVEFVGEVVPAQSRHEKQLVSRGTKSRNCKCKYTCSVEISAISAHNLGNLGPFVICTKVTNSIALLDPFTLRHCYLDADQYWRSPFKALHTSRQLVEYIVLDVKVASTENDTILSTRTHLGHLLILGDYAIGYDLHEANQNDIELENYKSLVPPDTIKIKKSYKEKNQRKHRKPNPPKLKPLEMEVDGSKCGADREKVNNEYEEFLRDLMASVTDKEDVPSVPLDYLLADLDSSDKEEGDDSMIE
The following text describes a protein:
Function:
Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MASGPRPAVPEDSVRTVSPGRRGEKTVSAPTGELEAAGTLKSVVSPVRSVVASPRRVKGKAGREAARRRLQLLSVSQAEGPGEGPDEKEEPLLSVLEEDDEEAQPLPPVCVSPTRGMWRDEKVALYCDGILQDCKAEEADDAMSKYLSEKLKLKDKWLGVWKTNPELFFVKYEEASIPFVGILVEVTCKPHQSSSSCFKVTVSVAEPFSSNIANIPRDLVDEILEELEHSVPLLEVYPVEGQDSDLHDIALALEVVRFFYDFLWRDWDDEESCENYTALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQNNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKRDFGKTITHIVAKVMTTEMVKDLSSDTLLQQHDDLDLALDSCYSGDTVVIFPGEYQAVNLALLTDDIIIKGIGKREEIMITSEPSHDSFVVSKADNVKLMHLSLIQQGTVDGIVVVESGHMTLENCILKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNNLRTSDSSKSTLGGVNMKVLPAPKLKMTNNHIYNNNGYGVSILQPTEQFFIVAEEALNKGAASGDKKDDNMLSKVMQNLNLEMNNNKIEANLKGDIRIVTS
The following text describes a protein:
Function:
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Sequence:
MSTLEFIKECQEKVFSGNHITAEDAEKLLNIPEENLKDLARCANEITRDFNGEKVDVEQLNNIKKNACSEDCTFCGQSAFFDTGIETYQLPSPEEVVSKAQKAKEEGAESYCLVAAWREPSRTDFEKVCKIITEINDKVGISVECSLGFLTQEQAKKLKDLKVKRYNHNLETAKSKFPEICTTHTYEDRLETLGIARDAGLELCTGGIIGLGETREQRLELTLELARLYPEEVTINILVPVPGTPLELQTDLPNSEIVRMFSVIRFLLPESVIKISGGRETNLEDSGEELLQSGANGIITSGYLTMGGNEAQKDHAMIEKIGLKSQ
The following text describes a protein:
Function:
Receptor for the egg jelly ligands inducing the acrosome reaction. Could be a regulator of sperm ion channels.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of the sperm flagellum and also on a thin belt of membrane directly over the acrosomal granule at the anterior apex of the sperm head.
Sequence:
MSVFVILILFNAILNFKTVGPAAVSSKTVDCASAPCMNGGTCADGFNNFTCFCEEGFTGSMCETEYGCFRPWFYGPAFGYCYLWERVDYNWTQARESCIDQGRGAELASIHSAEENAFVYAQIRRYAWIGLSDQVTEGVFDYADGTPVDYLSFPDKNKQSETRDCVYVKHLRVDNWSLLDCRANKTSICKSTTTFSATDGCATGWVHNPATGYCYFYEERGGMWSKGREFCLDAGADLASIHSAEENAFIFDMLTEFVWLGLNDLETEGVYTNFSDGTPADFDNFPADNYQNEDHDCVSIRHLEKTDRYWFFLGCDDTVTSICKRPHEVVATQAPPYLFTTTDVPATTTTIPTTTTTISATTRTIDAMILIELLLFPNNVSSIDNIFRVNNTILVTASVLGSFQALSSQILWSITNHLSGDSVQYTVYSEDAVLVRFTTVSIFTIKATAVGNSHNLTATANATVKHVCISSLTTSVKEHCDAPHPAVYLRAFDIHISTHMELNGKCIDPMTPDFKWRIFTSTEADDVVTAFEKITHTRQVMIPRGTLPYGIYSLNLNAKTRLKTSGEVTGEKEIISWLEIQPPPLVAVIKGGASRSHGVSSNLIVDGSNSYDPDVPPGSSSNVTFLWYCVVVDPDVMYSSLDEAIQNTDNACFEDEGIMMNSTSSMIEVIANKLNANVTMNFWLNISKEGQISGLTQQRIHLTLGLLPEIEISCISNCNMYIFTAERLVLHASCTNCDSENEDVSFRWSLESNHTSVIGDLSSQTTTGLDQPYLVLKPLTFDSISEMGSIILRVTGSQSDSDGYAEFSVDLPHNAPPALGSCVVTPDEGYALQTDFTVTCSNFTDVDEPLTYQIILFSHVDVVDWMFVGRGEGFQLYEGSAPIKDGLYLPVGVGTDDHDILLQVNVRDCNMASTSVYISATVHPPTLDAVGMNLVQELLDMALLVETNVNALLAVGDPGQAAQLISALGSILNSIGDEDDSEEGRETRSEIRSFLVDCVAAIPVESMTSLKQSSAALAVVTHNKQEISTHVQMLAASTLSEMTSFVKSKSGSYTQAQENIESAGTILVEGLSNILSAAKETERLLSDDTSQEREDHKNLIEVAVSTINDIQDAIVAGKIPSEAATIITSPALSIAVGSISRDELAEATFGGPEDLGSFRMPSQDVLNQAMEHALGTTVSMKMSAMKWNPFSWPGAGGESIKSSIVGIQLEADQMLEFHDLTADIDVYLPMRETLSADPVSVHITKTSSDSVLIDHSSLPVDGALHLTVIAENEPMVALSICTARISITESSCVGTDTPLGVSNEDPDTDANFTWTVPLVDLKAADGIMIRLYDSEDQPGYENDNITLSVFMHTLQCNFWNEDQQEWDSTGCKVGPLSKPSTTHCLCNHLTGFFGSSILVPPNHAQPVIGGHKLTGVDFLICVLIGYGIYCVALVIRVVGCSFAIRVHKVL
The following text describes a protein:
Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Subcellular Localization:
Cell membrane. Late endosome.
Sequence:
MVLDSPLKLEYPLHYAVYNNQQNDLKELLANQSTLEIDKIDPRGRTALMLAVTIGHFECANLLLESGADASIPNKEMWSVSNEAVAQGNGAFVQSVIQHRDFQRATRGAQAMKRSLEKLREVPDFFCEMNWDFSSWVPFLSQACPSDCHKVYKKGSSVRIDTTLASFEGTNWVRGNQSYMFRLSNEGFAEFIVLNHDERVAVVQELRDDDILNEYRQSPGAMDDRLSNTISTTFIDVDNIGFERTSRGFLSWFTSGEGNETVDGYDCKVLNASNVHLVTKRRYDHLSAEARERLAQEEASESKAVASFKKMMSTNKSDENTRRDLFAEGLTADQYLDANFEFEPGCDIGKLREVVKRSNGFKATLWMADEYPLSLHDQIIPIVELMAVNSPHFARLHKFIRLQLPAGFPVKIEIPLFHIVSARIAFQNINAPGKHVIPIEGRDVLIEDEAFSIPDGYVIDDDDYGRYGITWEDDDDRNNRNSQRNGTGGAGERRGVPRHANPYSEEMMIQMAIEQSLRESSGTSSSQNPRTEVQVLQDLMHLQQFNTSESSTSSDTEFFRAIRDSQADEERRRREEEAFEEEIRKVLELSKLEK
The following text describes a protein:
Function:
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
Subcellular Localization:
Nucleus.
Sequence:
MLQSNPVIHPNTSNRHFKFEPFLRQEYNFGLDPDRPVCQFYNPLNPDNSCPQGNNCPNKHVSAMYSNKIVCKHWLRGLCKKGDHCEFLHEYNLRKMPECLFYSKNGYCTQTSECLYLHVDPQSKIPECLNYNQGFCSEGPNCKNRHVRRVLCPLYLYGFCPKGPECEFTHPKFDFHNLNLRIRPDNLIQMTSKHVDNSKEESDKKEDSEPKEESI
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MFVKMEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAEFKMKMKLDIVCIPDEADMGTADSLRHIYPKLKTDVLVLSCDLITDVALHEVVDLFRAHDASLAMLMRKGQDSLEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYVVDFLMENESITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLTFAPYDVCWNACQEDRREDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLPILCPEESLIHSSAQIVSKHLVGVDSLIGSDTQVGEKSSIKHSVIGSSCVIRDRVTITNCLLMNTVTVEEGSNIQGSVICNNAVIEKGADIKYCLIGSGQRIEAKAKRVNEVIVGNDQLMEI
The following text describes a protein:
Function:
Increases proliferation of preadipocytes without affecting adipocytic differentiation.
Subcellular Localization:
Cytoplasm.
Sequence:
MWQPATERLQHFQTMLKSKLNVLTLKKEPLPAVIFHEPEAIELCTTTPLMKTKTHSGCKVTYLGKVPTTGMQFLSGCTEKPVIELWKKHTLAREDVFPANALLEIRPFQVWLHHLDHKGEATVHMDTFQVARIAYCTADHNVSPNIFAWVYREINDDLSYQMDCHAVECESKLEAKKLAHAMMEAFKKTFHSMKSDGRIHRNSSSEEVSQELESDDG
The following text describes a protein:
Function:
This protein binds to 23S rRNA in the presence of protein L20.
Sequence:
MYAIFVDGGRQYRVEPGMELDVDYRDIAAGENLKFETVLAVGAEDGLKLGAPTLDGVSVSASVLGMSQDKKIYIQKFRRRKHSKKRTGHRQKNTRIRIEEIAGV
The following text describes a protein:
Function:
Heavy-metal-binding protein. Binds high amounts of zinc. May act as an upstream regulator of the salicylate-dependent pathogen response. Involved in abiotic stress responses, and seed and flower development.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing HIPP3 show delayed growth of inflorescence.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Weakly expressed in the cytoplasm.
Sequence:
MGEKKNEGDNKKKGGDNKKKNETPSITVVLKVDMHCEGCASRIVKCVRSFQGVETVKSESATGKLTVTGALDPVKLREKLEEKTKKKVDLVSPQPKKEKEKENKNKNDEDKKKSEEKKKPDNNDKKPKETPVTTAVLKLNFHCQGCIGKIQKTVTKTKGVNGLTMDKEKNLLTVKGTMDVKKLVEILSEKLKRAVEIVPPKKEKDKENGNENGEKKKGGGGDGGGKEKTGNKGGGEGVNMMEYMAAQPAYGYGYYPGGPYGYPIQAHAPQIFSDENPNACVVM
The following text describes a protein:
Function:
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MVNGPYPRPSRAAAWRWRCQVGLRDQATGEAHPRGWRRSRQRWRGRSRVGGEDRGDRAGPPPPPPSSSLAGLLAHSSSGRGGRVRRPRGREAHRPPESLGLATWRREITAPRTKDTISMGTADSIRHSPHARAPARAMMMSSSSMAAGAGSSELIYRGGHDAPAADEAGARYSSSAKPPPPPHGNKPWLARPLRYMMGEQRLAFALLGMALASLVFLLAPSGSGSGSAAAASSGTTRTSSSVAHLAAVGLASRQYSSRVALFEEPRGGVRPGRVPLGLKRKGLRVVVTGGAGFVGSHLVDRLLARGDSVIVVDNLFTGRKENVLHHAGNPRFEMIRHDVVEPILLEVDQIYHLACPASPVHYKHNPVKTIKTNVVGTLNMLGLAKRVGARFLLTSTSEVYGDPLQHPQVETYWGNVNPIGVRSCYDEGKRTAETLTMDYHRGANLEVRIARIFNTYGPRMCIDDGRVVSNFVAQALRKEPLTVYGDGKQTRSFQYVSDLVEGLMKLMEGEHVGPFNLGNPGEFTMLELAKVVQDTIDPNARIEFRPNTADDPHKRKPDITRAKDLLGWEPKIPLTKGLPLMVQDFRNRIFGDQQQKDANANAGDN
The following text describes a protein:
Function:
Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell surface. Golgi apparatus.
Sequence:
MPFWALSVVISCLLPAPQHLVQVTSQDASLLASDSESLKCFSRTFEDLTCFWDAEEAAPSGIYQLLYAYPGEKPRACPLSSQRVLPFGTRYVCQFPAQDEVRLFSQLHLWVKNVLRNQTLSQRELFVDSVGLPAPPSLIKAKGGSQPGELQISWEAPAPEFSEFLRHELRYGPKDARNATGPTVTQLLSTETCCPALQRPNSAPALDRPPCAQPMMLRQDGPEQTSPTREAPSLTVKGGRCLISGLQPGNSYWLQLRSQPDGVSLHGSWGSWSLPVTVDLPEDAVEIGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRTRCCPRDRDPIWEKCEEEDQNPGPQPSRLSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLIPTPNFHWREVSSGQLEVAWQHPSSWAAQETCYQLRYIREGHQDWKVLEPPLGAQGETLELRPRSRYRIQLRARLHGPTFQGPWSAWSDPLRVETASDTAWITLVTALLLVLGLSALLGLLLLRWQFPEHYRSLRHALWPSLPDLHRVLGQYLRDAAALSPPKAAVSDAYEEVEPGLLEILPKSSEKTPLPLCSSQAQTDYRGWQPSCLGTLPLSVCPMAEAGSYCTTHIANHSYLPLSCW
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Subcellular Localization:
Nucleus.
Sequence:
IIIVLKLEILQTECAIIGSPQNYLAQSLEKVLDPSLSAIAAQKNIGTDFGGPGMLGSSIAPRAEQASNNLPYGVPYSGAQGIVSSSIGQALEPDHNNGRAVVPDHNNMFTGGSYGTVSAQNTVNASMVEPRSQQPSLRSHHNQRFTVSGTREALTPPSNTYEHPEKPSYQQLPPGYINRTPVARNVSTSRVVPISALHPYDTRWTIKARVTAKTAVKHWNNARGTGRLFSFDLLDGEGGEIRAVCFKEAVDQFYDLIEVDKVYLISRGSVRPAQKQFNALNNDNEITLEALTSSVEICSSDDYNIPRAQYNFRQISEIEDIDSQTVIDLLGVVTSVGPSVLITRKNGIETQKRTLQLRDMSGWSVEVTFWGNFCDVEGQQLQLQCDSVQPGKNKPDFSDADRLRQWYIAEGENTACVSLSREQFNSVQAVRKTIAQIGDGNLGRDKANWITVKAAISHVHTDSFCYPACPLIFNEKPCNKKVVDCGDGTWLCERCDKSFGNCEYRYAVRFQIQDHTGTIYVTAFQEAGEHIFGCTAQELHTVRNIDRDDARFTEIIEGARWHPNLFKLSIREESFNDEPRVQCKIVNAEKLDPSKESSILCKDIDSLLQGRSGPSTGDQGNFATNIGFSKSPGGHNVLTSNNAYGMNVCGVNQFGQKGSVSGGMSTPSTCMDNQQQPGAGGFIGNNYGGFMGGNYGSSAAGNGRPGSCFKCKQPGHWAGECPGR
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MTSRKKFGIPWPECNDGLSYDDVVRASDAGATLIEFYSTKYKSSAPLQGWLQRIKSGQITVDGGVVTDSNTVLRVGSKLIYHRLPWKEPDAPHMIDVLYEDDDMIALNKPSGLQVLPGGLYQQRTILTQLQWEANNQGTCEMHKRLHPVPVHRLGRGTSGILLCAKTKLARARLASHFADGTSHVGGKRDTKQELGKIAKMYRALVSGIVENDKVTINQPIGIVKYPGVAKGLYVASESGKPALSVVDILETNIQENSTLVQVKIQSGRPHQIRIHLSFIGHPLLGDPLYGVGGQPKCLDCDFVDESFAEDGGYQRPTKPVPGDCGYYLHAHKLVLSHPTTNELIEIIAPLPSALHTAEEAKEIAIMQQTA
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Sequence:
MGLKINRPRRGSMGVYPRKRAADIVPRVRTWPEVNLGKPALLGFAAYKAGMLHAVVVDDRPTSPLYGKEVVKAVTVLDAPPLYVWGFRLYTLDPTNGYKRAVAEVWASELPKFLHRVLTLPEKLDVDKQLKKVEEFRDVAVDVRALVATQPHLSGIGKKTPELLEIPIGGVPSVDERINFAISLLGKTVSPKDVFTPGQLVDVIAVTKGKGYQGVIKRFGVTILPRWHKHRKGHRRTGTIGPQAPAVMFTQPRPGQMGFHQRTEYNKRLLKIGENGAEITPKSGFPHYGVVKGPYILIQGSVPGARKRLVVLRHPVRPPRKAPPAAEPQVVWVSSQTL
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MLNEAELGGGLGLAVALMYERSLGEKSKWAGYLRLLPFQQCLPFVWEMSEIDRLLTGTELHKTLKEDRKLMRSDWKECYEILLELFGEETFPAKWFSIEHYFAAKTLVASRAFEVDDVHGFGMVPLADLFNHKTGAEDVHFTSVLSDSDSDSEQDEPTTPGSADEAVEKTSDETPKKEPRKGGKLIASVDESPKPKEAILKRCKSAPTVNLSPKPEGLTKKNKFNPAAGEDETVKAPKPVDEENGVEGNSEEDNADWEGSSEVLEMIMVKDVAKGSEVYNTYGSLSNAALLHRYGFTEPDNPFDMVNVDLSLVIEVCGRLSSTRHARRCLTLWRKAGCAPCSSQGSEYFEFSVDGKPQPELLVLLYLIHTDDATREKIEKDASQWNAVEVELSDDEIDRVSSAAVDKLAKALGWASKVKKNSTSRKRNRDDRATPNGSNKRMTPLRASAKPREEDPSWLSDLDKWLLTKSVCICLLAIVTERDSIFPGVGSLTSEKPVGGSVGSSLEEDRVFFRNIDCKSDAKLYHAMFLRISERTILDKCATLMRIKSQKR
The following text describes a protein:
Function:
Kinesin motor with a plus-end-directed microtubule motor activity, required for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, axon. Cytoplasm, perinuclear region. Synapse. Cell projection, neuron projection. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions. Expressed in distal regions of neurites.
Domain:
Composed of an N-terminal active core containing the motor domain (MD) and a neck coil (NC), a central regulatory center required for dimerization and activation and containing the FHA domain and coiled coils (CC1 and CC2), and a cargo-recognition region containing a coiled coil (CC3), an undefined region (UDR) and the C-terminal PH domain.
Sequence:
MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKPRTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADAGPSADEVNNNTCSAVPPEGLMDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGACMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDEALIDPNILSLNILSSGYVHPAQDDRVFFGNDTRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETTQRPGPEVLSPASSEDSESRSSSGASSPLSAEGQPSPLEAPNERQRELAVKCLRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQANSDKDMHDWLYAFNPLLAGTIRSKLSRRRSAQMRV
The following text describes a protein:
Function:
Probable transcription factor required to initiate organ founder cells in a lateral domain of shoot meristems. Involved in leaf formation.
Subcellular Localization:
Nucleus.
Sequence:
MASSFNNRHWPSMFRSKHAAEQWQPQPDISSSPPSSLLSGGGNTTNTGGSCLNKHPSSGYAGGEERTPDPKPRWNPRPEQIRILEAIFNSGMINPPRDEIPRIRMRLQEYGQVGDANVFYWFQNRKSRSKNKLRAAGAARPCPARAPARAAAVTPPPPPPPAPPQLLTTTQQVQLLASPVPQAAPTSSSSSSSDRSSGSSRPAAKRAAQAMSPTAAMDLLGPLAAACPQMYYQGQPVAPPASAPAHKVHDLVASDEPIFQPWPQGCCLSAAELAAILGGQYMHVPVPVQQQPPAALPAGAFLGLCNEVTEPAITGQRTCTTWGAGLGQYCPGGGAEHHQLGKNTDAAPAREVAHEDATKLGLLQYCFGDSTAVDATAGAATMRDAAVTVATVAATATTARLTGLPASSAAPNGVVANYDLMQLQGM
The following text describes a protein:
Function:
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Seems to be the major transcript.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; Extracellular side. Cell junction. Secreted. Note=Concentrated at cell-cell contacts in cultured endothelial cells.
Sequence:
MVARLTAFLVCLVFSLATLVQRGYGDTDGFNLEDALKETSSVKQRWDHFSTTTRRPVTTRAPANPAERWDHVATTTTRRPGTTRAPSNPMELDGFDLEDALDDRNDLDGPKKPSAGEAGGWSDKDLEDIVEGGGYKPDKNKGGGGYGSNDDPGSGISTETGTIAGVASALAMALIGAVSSYISYQQKKFCFSIQQGLNADYVKGENLEAVVCEEPQVTYSKQETQSAEPPPPEPPRI
The following text describes a protein:
Function:
Receptor for cAMP.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGGDIHLCSMILGKNHLIFLYFANLFGSTLSFLATIITIVFYLVKKYIQNKSFRENPHQYCHQHQYFDSSKLNEINNSGVGSYSSTPISIQNNNNKNNNLPKQKNNEKQPLINKNHNNYCNYSTSATSSSSSSSSFSSTNSGSSYEYQQPQKNQQTLSSSDKNNTIPSTNTKYEIELSIPQFKGNKCGPNCLLFSNIPQIKNALEQKKNPKKIDTLIFYLSISDFIAVSGIIIEQLIIIFNKEISKSIGFCIGERVSIHFGLLATLFWSNCIAYYLLRETYELKPYNIRFVYFHIVCWGMALIGVASLFFSKIITVSNIDQGGSWCSVSSSYQLYFWVIPLFVSFTWNLICYCLIYRKFNKIIGIYGIQSVQIKTIIIRKLSFYLLAFLITWVWDVINNSIFLYEGKCPPFALWILQEFFSSGYGFFNSLAYAVTTRFYSRK
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the ARP2/3 complex. Interacts with the active form of RHO-family GTPases.
Sequence:
MAVPVEEAIAALSTFSLEDEQPEVQGPAVMVSAERAATDSPIEYSDVAAYRLSLSEDTKALNQLNTLIQEGKEMASILYTYRSCVKALPQLPESMKHSQADLYLETYQVLDLEMSRLREIQRWQSSASAKLAADMQRFSRPERRINGPTVTHLWSMLKLLDVLVQLDHLKNAKASIPNDFSWYKRTFTQVSAQWQDTDTMREELDDLQIFLSTRWAILLNLHVEMFRVNNVEDILQVLIVFIVESLELDFALLFPERYILLRVLPVLVVLATPSEKDTEALYKRVKLNRLINIFKNDPVIPAFPDLHLSPAAILKELSVYFQKFSSQTRLLTLPAPHELPPREALEYQRHYLIVNHIGALRAEHDDFTIRFASSMNQLLLLKSNDGAYTEWCREVKGNMYDMVVEGFQLLSRWTARIWEQCAWKFSRPCRDAGETPEASGSYSDYEKVVRFNYTAEERKALVELVGYIKSVGSMLQRCDTLVADALWETIHAEVQDFVQNTLATMLRTTFRKKKDLSRILSDMRTLSADWMANTRPEHEMPSSQHGNDESRGNFFYPRPVAPTAAQVHCLQFLIYEVVSGGNLRRPGGFFGNNGSEIPVNDLKQLETFFYKLSFFLHILDYSASIGILTDLGFLWFREFYLESSRVIQFPIECSLPWMLIDYILEAQNSGLLESVLLPFDIYNDSAQQALVVLRQRFLYDEIEAEVDHGFDIFVSRLSESIFTYYKSWSASELLDPSFLFALDNGEKFSIQPVRFTALFKMTKVKILGRTINLRSLIAQRMNRIFRENLEFLFDRFESQDLCAVVELEKLIDILKHSHELLSQDLSIDPFSLMLNEMQENISLVSFSSRLATQIWSEMQSDFLPNFILCNTTQRFVRSSKVPPTQKPSVPSAKPSFYCGTQDLNAAHQSFARLHSGFFGIPHLFSIVKLLGSRSLPWLIRALLDHISNKITTLEPMISGLQEALPKSIGLLSFDGGVTGCMKLIREQLNWGTKSELKSEVLRGIKEIGSVIYTMGLLDIVLREVDTKRFMQTAPWLGLIPGAEGQIVNAQDGESPLVNLLKSATSAVVSSPGCLNPAAFYTMSKQAEAADLLYKANMNGGSVLEYTLAFTSASLDKYCSKWSAPPKTGFVDITTSKDFYRIYGGLQIGYLEEITAPQSAQHEVLGDSIAWGGCTIIYLLGQQLHFELFDFSYQVLNVSEVETVSASHTHRNPQIHQGWEGLLEGMKKARRLNNHVFSMLKARCPLEDKTACAIKQSGAPLPRVRFENTVSAFETLPQKGTVG
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSTKNALNDSQIKLLNSLNDNKGIPSTEFVEKFAESLYETQNDGSKKLSSIDGSIKSFAACLHELNRLKSRVGDRIRDYASASKQVQNEYHQKSNHLREKFAQVLELSRHLEDNVNDMRSGLVDAGQELERAENNRKRILSSAELLRYYLEFRSGKPQTLMDFFRTNNHDKMLLCAQRTRQLLALANEVDLPDSSETLARIEKFSEFLETNFLKFFNNEYRKPNWKGMASFGTILQEFNGGASVVREFVNQHEFFIAADKVQSRQGLEQDPIWLILPDPTQKIPPLIQTLSSLFSELCSVIEGDCAVIKRVFPNPELVLQTFFQRIFGQSIQNRLEEVMEIAKGKSNLAYLRTLQTVVSSLRKLVADLKTILENRGFSVSDNSPLSLALNQYMEDLLVPFIEVDDYLKREEHSLRSLFRLSLYKYTSYKIRLETPEPGLLRSLMTPLQGNMVAPTGVHSQFNTKTEGFLLRIADIQENLIQSGSFITEDYITIEKNHSHLNSEKVYSFIGWHAEALNRASILISSQDLSVVISSLVNLLDKLIREDYVFKELSSIQSYISSHDKSKNLDLHYLVDIRECKKIMGYFSAYLMSIVIPFTGVTASSRRETVNILSSSISVIECAVNDVFYATVHALGDHLEIILSPYRQISYAMTEEQIDSSTELRQSMTRNVQNYLDYIKNLYHRLGPYDPSLLALKQKTATMLAAMLISFAFRSKVTAAGALLLQNDINFFHSTLTSWGIDTVDAKFKLILQLLSLLMVKIDVLPAVMQDKRKAGFSEMNIHEVLRLRFDLPENLKLQLNKEEALLPPKSS