lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MMFDDLDNIPQLPEDISMNQFIQQAKVEMQAARQSPVLPFHSKGSTTRTNIETPPTVPLLPTPQQKTNGGTSSNVSATNDSSLMTNPLRVRAKLDEERLLSPTGLPLLLKCAKKMRFGGKGSELKNLERLLKMYQIWGLEVYPKLKFGAFIERTENVCKKRRMKLFMMQLMKNQERKELGIHGIEADYDSQAEQTSDDDCEDHIRVDPNADIYEELELQRAAESEAFANTIAQDPSLDLTEDLDDQIPVSQSLLLKRRKNAIVDSDEDTENTAPSRNPTKSLISDQPRYKRSTLNLPESGSTPTTSNLTSNSASDAELALKQKEIIDSNRQRAMLKLAEKQAERERALKNTRRVEEEARVAAMLAEASPFFTDN
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MVLIWNIPTGHISDLILSTHKTLIMVNPTNLTTAKENLPRIEIGQAIYKIQTILLDVHQCSQQQLLSAASLLSQPDYADIVTERSIAKMCGYPLCPNSLPYDRPRKGKYRISLSEHRVYDLQESYQFCSEECLINSKLFAGTLVVERRDEMSGVKILDALDSFEGVSKVVNDRDKKKEAGKFYRDLEVGDLGFSNLKIREKSDVNKGEVLPFEEWIGPSNAIEGHVPRDRNLGMNSKVKIKHEKDDKCEEIKNKIEFTSEIFLGDPLEASSSNCKEKQDDHTLVSSFKQKRLKERKHTVKWADQEEAKSTSILSNELKEDDESSVRIANAEACATALLEASEAISSGEFEDENAVSQAGLVILPNPYNHGKSESITNVEELQFSKNTMKWPTKSVLSNDDVFDIKDSWYDTMPPEDFTLTLSTFATMWMSLFEWVTCFSLAYIYGQDETSQEEFSDVNGREYPHKISMIGGRSLEIKQTLAGCISRGLPEIVSYLSIPTPVSNIEKAMSQLLDTMSFVEALPPFKSKEWQVIILLFVESLAVFRIPTLAKHMKNRRNLQYKILHAAHLSVDEYETMKDLMNPLGR
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYSGSFQEGGASELVSAAFLDGASWSAALWLFLGLVGTAAGWQHLAPQLPVAMASFRTGFLSWLNNTRYRIGNTAEIRTGEMMFLLGAAYQVPPRPDKEAPEEEQAAAREALRMFAQQLEDDVATRIWFTYRKDFPPLPSSRRTTDVGWGCMLRCGQMILATTLMAVLQPRVHHLLKYTMENHHLKAGRFQGPSSVGSALLHQVPSALAQLNQFRDEEVKLRTYFASDTLVILDQLRPEEGQAEFEPIMLVLPLRLGIEKIGPQYHARLQLLLRQPWCMGFIGGHDKRAMYIFGYQGHQYFGLDPHRCSAAVAQSTAELRDRWVEVRDSFHTSKLSGIERDDLDPSLAVFLLARTAEELDDMLSVIGQPTSEDRPGPALVSVVQHSPVGLF
The following text describes a protein:
Function:
CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition.
Subcellular Localization:
Nucleus.
Sequence:
MGTSVQVTPLSGAYGEGPLCYLLAVDGFRFLLDCGWTDLCDPSHLQPLAKVAPTIDAVLLSHADTMHLGALPYAMKHLGLSAPVYATEPVFRLGILTLYDYFISRRQVSDFDLFTLDDIDAAFQNVVRLKYSQNHLLNDKGEGIVIAPHVAGHDLGGTVWKITKDGEDVVYAVDFNHRKERHLNGTALGSFVRPAVLITDAYNALNNHVYKRQQDQDFIDALVKVLTGGGSVLLPIDTAGRVLEILLILEQYWAQRHLIYPIYFLTNVSTSTVDYVKSFLEWMNDSISKSFEHTRDNAFLLKCVTQIINKDELEKLGDAPKVVLASMASLEVGFSHDIFVDMANEAKNLVLFTEKGQFGTLARMLQVDPPPKAVKVTMSKRIPLVGDELKAYEEEQERIKKEEALKASLNKEEEKKASLGSNAKASDPMVIDASTSRKPSNAGSKFGGNVDILIDGFVPPSSSVAPMFPFFENTSEWDDFGEVINPEDYLMKQEEMDNTLMPGAGDGMDSMLDEGSARLLLDSTPSKVISNEMTVQVKCSLAYMDFEGRSDGRSVKSVIAHVAPLKLVLVHGSAEATEHLKMHCSKNSDLHVYAPQIEETIDVTSDLCAYKVQLSEKLMSNVISKKLGEHEIAWVDAEVGKTDDKLTLLPPSSTPAAHKSVLVGDLKLADFKQFLANKGLQVEFAGGALRCGEYITLRKIGDAGQKGSTGSQQIVIEGPLCEDYYKIRELLYSQFYLL
The following text describes a protein:
Function:
Required for the early stage of chloroplast development. May be involved in chloroplast protein biosynthesis and/or degradation.
Subcellular Localization:
Plastid, chloroplast. Note=Accumulates as spots in the chloroplast.
Sequence:
MISSLSASSSLVSSFVAVKATPVTGPLIPRRDLLSIRIRASSNQNSSGYCFPEKFKSFAKSAILIGAAVSMTGKFSTLPVKAESPVTTIEKTYEEVKEEKLSEITPLSELLDSTPEAVETLRSLLQQKLEKGEDEEALKLLERLVAAQPEETEWKFLMARLLGEMGRPENARQMFEEILQRNPLSFEALFENALLMDRSGEGNAVLQRLEDALAVAEAEYLVKEARDVRLIIAQIHFLQKNVDEALKSYEQLTKEDPKDFRPYFCRGMIYSLLDKNVEAKEQFAKYRELSPKKFEVEGYLRTPLSKMKLFGGSEEN
The following text describes a protein:
Function:
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Sequence:
MSNEISATTESRPANDLDKLTSLFNEEIYVRTDANSIPASKFKIFDDLIEFYKSAGKIDEAKRKIEEYLSEHEDSISARYLLGILSLERGEISDSGLLKNLLESFKVASKWAIIEHITDQILKYGDQRLALKYKAEALEKLKKNKELKIVLEKLAKHDRKNPEILKKYALSILEENKEKAITYLKQAIETFAKTKDYVQLEEIWSIIVNNNHEDLQFFERIERIMLGHRERTRLVGYLYPIVEPYKQLEDWDKVIYLLKKILEHEASSNKARNELIRAYKAKYVNHSLLEDFLKMSEIGNNRKPIKVCIANFERNIVFDTNNYVLHRNWGVGKITSISPNGDSIFVDFKDKKDHKLSIQMAITSLKPLKRDHIWVKYYENKDEITELFKNNIPDFFKELLTSFNNRMLTADIKSEVSGKFLPVAEWSKWWNKAKNIIKKEPNIGFDPKKKDELVYREKAISLSEELSEKFAHQTDANKKLDIAMEALDNREDAEGAIEAFNHFYYEEEEAADPVRKIVAFLYLQTASEELGDEEIPRHLNESKIAELIKSLPVSSLIEVSTKIGNAEIKKGYVNLVRKHAHNPEEVLTGILFEVPIKVNKYVFSILEEEGKFDLLNSFIKSAGTRAKETPEVFIWVAKSILTKVWEGEWLLSSKQEERLELILKVFRMFKPLTKIEDKGTKLKNACKDILHGNDDEILREAIHAGNSEYIRKLYALYKEVPYFTDLEKERLYSLIVELKPDVAWEEDEDEDEEDDDILTRIPEGAILVTRRALNRKKEEFEHLLNVEMPENSKDIGEAQERGDLRENAEYKAAMEKQVQLQAAIKRLEAEIKSAIILDLTNVKTDKINIGVTAKLKNESTGEVVAYSILGAWDADTEKHIISYQSPLAKSLLGKKTGDSAVLNLTGAETRYTVLDISRFSLQSQEN
The following text describes a protein:
Function:
Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MMRIRIIAFALFLTNITMLAGTSTHFLDIEELKSIHYDIDILEKPVLYGRPLHTSVVYLSSKFGQRYECQLPDVADVGKVQDEEKTAAETGISYLLKPMELAPCLLKSKDWWTYEFCYGKHVRQFHLENNQISGEVITIGVFESEMDWENKSHSAAKRHRLNRYHSHRYVNGSNCDLTGKPREVEVRFLCAENELDTMSRIDEPESCRYVITVHTMRICHHPYLKLPAKAKPKTILCYPLLMPVQYDHYMHQQTKHRYSKEAQEGDSAEGEEGDGEEGTTQDPDDYDYEDSDDLELLEEHHLHGDMSTPGPDKDITGKGDPTEMDVHPDELAELLTEVLKGVQGTIGKINSRLEDADPKMMEGRTNKDGEEEMEDYDDYEDEDEDEEYMELLKMDYKELTKYIQELPTTDQEEATELAKLAQEIADSFENIEAMERVLEQIEEDVSDLSPALDDPMQPGDTPSGDPSADPLGDPSDGPSDDPSDGPSGDPSNGPSGDPSDGPVTVLETNMKDGMTGEDQIKDDVVGEDSMKDEEEDEDEKEEERLEEQKKDLEDHLAVTLKKLMRQLKEQANFKGEAASSSESATPSESSDLSSRVRVRVTRVKLDKNQKASSEQEVKFLDTDHQDLEQAISEQLEKSGVNREDAGQLEVRILSYVPEDWPDQGMEDEGFAVLSEEDSSYFRNMIFGLVMKDDGEVQSRQDRLQKNYGFQWNADSDVDQTKVSDQDLEQEEVQILIPRIGTKDSAQGQGTSDPES
The following text describes a protein:
Function:
mRNA splicing factor that regulates alternative splicing od specific genes. Has a maternal role in embryonic dorsal-ventral patterning; such role is probably indirect and due to its function as mRNA splicing factor regulator.
Subcellular Localization:
Nucleus.
Sequence:
MQVPEHVVSLYIATCGQNGSGLGSDEKEIILLVFVLLEVSTGQIVGTKQILVRPDGYFIKDRTISSSSDNSSVTNNTASSPPLAIGDANNGSGSTSGNGNSLENGSELILPIAEAQAAGKPLSEAIEEFDAYLRSLSLHDTEIKLVTDGQLPLRQCLHREASAKDVELPAYYNRFSDLRKEFLRYKSGDLARALVPVKDVKKMLQAPTLPMPQSIAEMLGELNISSVEDNDFYIRESRDMVTVIQTLLQAGHKFAANELVNLVLEPGICSIDDEVDGNCIVRARGLPWQSSDQDIAKFFRGLNVAKGGVALCLSPLGRRNGEALIRFVCQEHRDMALKRHKHHIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQVIIRMRGLPYDATAKQVLDFFTTGDTPPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHRESIGQRYIELFRSTTAEVQQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQLPLLPQVGAHSLSHSLGASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFAKHIIYQGVHMVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYIEVFQCSGDDMNMVLNGGLASPVAQPPPPHLGHAHKQQSLLAATTGMFSSAGQSPTTVAAGTAQSPLGGTHTHTHPHSHAHAHATGHAHAAAAAAHHGLSASSAMLPGLSAAASASGLASFMSAGQQSAAAAAHSAASLQNAAVALAPQGYALNPFSLPPPGSAAAAAASTPALLAQQQAQFIAQQSLLVRQQAAAAALAAEQQQQQQQQQQLYASAMLQQHPLYLQQQQQQQQLYASAMLQQGQPQFVLMQRPSAAYLPPFPLSYMSAAGAASGVGVAPGAAVAGAAAAASPSASNSSLSQSMKRSYENAFQQEAAGAAAAASAAKRALTRQPSSVYSYYNSGI
The following text describes a protein:
Function:
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-141 results in accumulation in the nuclear speckle.
Sequence:
MPHPRRYHSSERGSRGSYHEHYQSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRQSYEYHRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSSRDISR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
Sequence:
MESPAVTFTLAYVVFSVCFVFTPNEFHSAGITVQNLLSGWLGSEDVAFVHYHIRRSSATLLAHSLLPMGYFIGMCFAAPEKELYNVHKAADGWKVFVLMAVLLPIATSILAFYWSQKRWSNHPLAKTLAHHALPQSSWRAVASSINTEFRRIDKFATGAPSARVIVTDTWVMKVTTYKVDVAQQQDIHLTVTDSRQHELSPDSNTPVQFITIRVASINPRVKPFDIRLNSTEYGELREKLHAPIRNAANIVIHQTLGDMFLDTFRSLVEANHTYEISSNQELEPCIGCMQTNANIKLVKYCQEANEGECQQCYCRPMWCLTCMGKWFASRQDQQHPETWLSSQVPCPTCRAKFCIVDVCIVR
The following text describes a protein:
Function:
Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion.
Subcellular Localization:
Mitochondrion.
Sequence:
MVRGRISRLSVRDVRFPTSLGGHGADAMHTDPDYSAAYVVIETDAEDGIKGCGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGFYRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPVWKLLVDMDPRMLVSCIDFRYITDVLTEEDALEILQKGQIGKKEREKQMLAQGYPAYTTSCAWLGYSDDTLKQLCAQALKDGWTRFKVKVGADLQDDMRRCQIIRDMIGPEKTLMMDANQRWDVPEAVEWMSKLAKFKPLWIEEPTSPDDILGHATISKALVPLGIGIATGEQCHNRVIFKQLLQAKALQFLQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLENRVCEYVDHLHEHFKYPVMIQRASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKKLLPAQEN
The following text describes a protein:
Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Sequence:
MNFKLNNTLSNEINTLIIGIPEHLNQLERISFNHIDITESLERLKHQHIIGSKVGKIYTTAFDVQDQTYRLITVGLGNLKTRSYQDMLKIWGHLFQYIKSEHIEDTYLLMDSFISKYDQLSDVLMACGIQSERATYEFDHYKSSKKAPFKTNLNLISESLIELDFIHEGISIGQSINLARDFSNMPPNVLTPQTFAEDIVNHFKNTKVKVDVKDYDTLVSEGFGLLQAVGKGSKHKPRLVTITYNGKDKDEAPIALVGKGITYDSGGYSIKTKNGMATMKFDMCGAANVVGIIEAASRLQLPVNIVGVLACAENMINEASMKPDDVFTALSGETVEVMNTDAEGRLVLADAVFYANQYQPSVIMDFATLTGAAIVALGDDKAAAFESNSKVILNDILQISSEVDEMVFELPITATERASIKHSDIADLVNHTNGQGKALFAASFVTHFSGQTPHIHFDIAGPATTNKASYNGPKGPTGFMIPTIVQWLKQQ
The following text describes a protein:
Function:
Transcription activator (By similarity). May activate expression of the pro-apoptotic genes ced-4 and ced-3. Required for constitutive, and for DNA damage-induced, programmed cell death of germ cells.
Subcellular Localization:
Nucleus.
Sequence:
MDPSSIDLGSIPGGSEQQQHEDGAAAAAGSPKEVFRSQQSLGLITQRFMSLRQRNEVLNLNEVAKELNISKRRVYDVINVLEGLGYVEKVEKNNIRWIGDNNNSEEQNALEARVEMLRQQEKLLELMIRDAQAIIELHFEDPIERPYNYVSKEDIRKTAEPNTKSIIVKSELDTSSSFEIQVTDPSTSGSHDMIVRNKNGVKSHALLFTNDPPEYGDEEDEDDVKKLSSQKRFETSEALRVTLAEMLTDPTTISSSPKHIKLEEPEEIDTEDLETFVLPPSTSASQSNAPYLPETPGRGLFFSPFKSLIDPCILPSFSDDLTSGYINITTPSRATGAGAGASGQEDEEPVSVMDFFSD
The following text describes a protein:
Function:
Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane; (Microbial infection) Probably transports the toxic C-terminal region of CdiA from P.luminescens strain TTO1 across the inner membrane to the cytoplasm, where CdiA has a toxic effect. Toxin transport is strain-specific, mutations in this gene do not confer resistance to several other tested CdiA toxins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA
The following text describes a protein:
Function:
Cleaves proteins C-terminally to mono- and paired-basic residues (By similarity). Required for cell wall integrity.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MQLISILSLLSSLMCSLTVLGSSASSYVKFPVQKLADIINICTQDVSTVFKRNEVLNTTVINGIGVYVVKMEIGTPPQTLYLQLDTGSSDMIVNNADIAYCKSMSDGSDYASTDNYELTATFNGLPSTTISSEAYNTLCSYWGTFDASNSSTFENNATFFNNTYGDGTYYAGTYGTDVVSFENITLNDFTFGVSNDTIGNPSGILGISLPIAEFTDGIEYALALNRTPFIYDNFPMELKNQGKINKIAYSLFLNGPDAHFGSILFGAVDKSKYTGQLYTLPMLQAFNTLGSNPGMIITAQSVAILDSESGNKTVSDIQFPVMLDSGTTFSYLPTEIAEAIGKSFDGEYSSDDQGYIFDCSKVNDTLLSVDFGGFNISANISNFVTSAKDRCVLNVKQSESTYMLGDAFLVDAYVVYDLENYEISIAQASFNNQEEDIEVISDTVPGATPAPGYFSTWVYKPGSPIGTGDFINVSWTSYSEFSQYKSLLATAAQSDDASSFSSSGGSSESTTKKQNAGYKYRSSFSFSLLSFISYFLL
The following text describes a protein:
Function:
A major immunodominant protein in mammalian hosts. Required for the initial stages of mammalian infection. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Binds human complement C4-B, which may inhibit the complement cascade (Probable). Experiments in mice suggest it may play another role after initial infection (Probable).
Miscellaneous:
MISCELLANEOUS: The causative agent of Lyme disease, the bacteria has an enzootic lifestyle. Larval ticks are infected with bacteria during feeding on infected hosts (mostly mammals) which retain the bacteria during subsequent developmental stages. It is transmitted to the next host when it is bitten by ticks. During tick feeding (which can last for several days), bacterial migrate from the tick midgut to the salivary gland where they are transmitted to the host; MISCELLANEOUS: Expression of the mRNA for this protein in infected mice occurs in different tissues (including host heart, bladder and joints far from the initial injection site) at different levels for at least 21 days post-infection, suggesting it may play another role after initial infection.
Subcellular Localization:
Cell outer membrane; Lipid-anchor. Cell surface. Note=Expressed in a punctate fashion on a subset of cells in vitro.
Sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
The following text describes a protein:
Function:
Binds the telomeric double-stranded 5'TTTAGGG-3' repeat and regulates telomere length and structure.
Subcellular Localization:
Chromosome, telomere.
Sequence:
MVLQKRLDYGSHGHRAPIKPRVATLAPVKRSTRIRKKQMYALDLLATAAEKLLADQDNLSSGPNINETPEGYVTSMKPVKAEQFDEAFPLRSVAVKKDDCKGCTVGCAGICGFLRQANMCLAENSSTQNLADSVLESLTAKPDVLAKDSFVSSKKSCRLGFGLGTIPEYGSVGVCQPWSTRSAEVKQVHRARPTAIRSQEDSDAAALCALVETMDLDTKPLAEASSGSNSGVHICGPDRGHNSHPSCLAKVQHAADRDDDENSSGCVHPSTSGNNRGYIPHYIGDRRIRRLFASRLRKAARNRICGEMSCKGNKLSLCEKKMPTTRRRVQQTTLKRKRLAQLYSEKSSDEVKLTIKSFNIPELLIEIPENATVGSLKKTVSDAVTTIIERGLRVGILLQGKNIQNDNKTLRQAGICRGKKLNDIGFTLECEAGQDSHPGVIVPEEMDFVGASVVDKSATVKCEEPAENQQLMQDFPGCSLSDPGSVDYPVEWSTQETSASSQAIVPFADPNSLALANVPLSRSKRPDFGQRRIRRPFTVAEVELLVEAVEHLGTGRWRDVKFRAFENVHHRTYVDLKDKWKTLVHTASIAPQQRRGAPVPQELLDRVLAAQAYWSEQQAKLHGDPPVPEICPT
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis.
Sequence:
MSIFDRMTTSKEAAMKYRQFCVSKKKEVWDALIYHAKYAKNIEKVYDMTTVLQRVQQECLMFALEKGVGQPDIRDAAELIFPLAMQKVVIKVLRPYFMSHFTNYRLAMYLPHRKIDHGIDLNQELWTPEKKEICGQYVQDFNPFVNELKTGILNANRHMNAALSVYIRELAATLVMHEKAAFDNELRCSMFQEIMESLRIWSDQVTMQDAFHLISDTIYKDVFQMLSKNAYEMIAVDFPVKFRSLITMKYCLLRTNNHGRVDFTNYLIDQVNTKLLVASVDTKDILKAYAACVESLREMDNSCVVMHKVCGVIREYLKRRPDTVQQIISYITSNKKNELEKDMSLQSKTVRSAMMDEEELKGVNDDFLPENMETLGWENWMPNPTDATVGDGAPGHQGVDVFNMLVSVYGSKELFVKEYRNLLAERLSSSDNKDPEFEKRYLDLLKLRFQYSELQHCEVMLRDVIHSLDIDKKFEDMSERSAGNYDVPIIPISACIISSHYWPKLETEKTEALMPQPLQAAMDVYQETYLDVKRDRKLEWLRSVGCVEVSINIDGVEVDRTIPNMYALLLFLFLEKETWTTAEVVEKMGMSVVVTRKRLEWLVKQGFICMNPIISSDTWTLTRNPSGISIVRPGTPDLEDDEDVEPEENSDMVDALEQYWGYTRNFIANHAPNGEVKAERMHRVYRMFGSPTSAGPTLDHVSAFLQRKVALGLLTCINGSYRIIQEKKDGE
The following text describes a protein:
Function:
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Sequence:
MPRALIDTSVLFAAAYKRDDSHDTALPALHGIDTGTLPEAVVLDYVLAETLNGLTTHAGHDAAVDLLDRIEENARFHIDSLTTSALATGKALFRQHEPLSFVDACIVAYMQTEGLGHLYAFDDDFDAVEDIYRLGTATNPYNST
The following text describes a protein:
Function:
Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (By similarity). May be involved in the regulation of beta-2-microglobulin genes.
Subcellular Localization:
Nucleus.
Sequence:
MAGKKNVLSSLAIYAEYSDPESDGETGVDAVGGATEEKGGLVSDAYGEDDFSRPGGDEDGYEEEEDENSKQSEDDDSETEKPEADDPKDNTEAEKRDPQELVASFSERVRNMSPDEIKIPPEPPGRCSNHLQDKIQKLYERKIKEGMDMNYIIQRKKEFRNPSIYEKLIQFCAIDELGTNYPKDMFDPHGWSEDSYYEALAKAQKIEMDKLEKAKKERTKIEFVTGTKKGTTTNATATSTSTASTAVADAQKRKSKWDSAIPVTTIAQPTILTTTATLPAVVTVTTSASGSKTTVISAVGTIVKKAKQ
The following text describes a protein:
Function:
DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.
Sequence:
MGCEEKLSGILELILPEDPLSDQTGYAFLRVPYKNSLVTVCGHLPLSLFKIGSSVDLTGHWSVDASGALVFRFTSAATYSPDSGIIAYLNAQIKGVGPKLAQKIVSTFREDTLTVLDSCPSKLVEVDGISPARCEDFSKQLQEQRDLRHALLFLQRHGIAIHYGLRLYKKYQNQTIEKVCQDPFLLAKEMYGIGFKTADLIATCLGVPLNSPNRIVAGIQYSLDELQEEGHTCYPLNDFIVLVEKLLNEEAPEEIIRKEEIRTQIHFLSRQKTVYVKELEQDTYIWSRQLFLAEQQIAIDIRRLLFSSKRIRSINTQEAILEVENLLDLKLEEKQKEALHASSSQKIHIISGGPGTGKSTIIRAILSIFEKISSPKKIILAAPTGKAAKRMTEITGKRTQTIHSLLQYDFKTLSFRKNHEDPIDCDLVIVDESGMIDTILLQRFLAALPDHAILILIGDVHQLPSVGPGNVLKDLILSHHIEVTYLTKIFRQLQNSNIITNAHKVNQGEFPVLNSSSGKKDFLFFQKEDPEEAIKHIIHLVSDFVPKKFGIFTKDIQVLAPMRKGVLGILNLNRELKAALNPNKLFIQGKFHSFSTGDRVMQTRNNYNKEVFNGDIGYVTSIDLSTKSLIVCVDGRYISYSQAELNDLIPAYATSIHKYQGSETSCIILPIHTSHYVMLYRNLLYTAITRGKKLVILVGTKKAVAIAVRNNKVQHRCTGLQQAMHSLLNKPTPLFSPYTICRPSLG
The following text describes a protein:
Function:
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix.
Sequence:
MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQFNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTDSSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSLVYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGWKAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDDVWACKAVPQAFLDNLKKLGYTDLLPIQRRVLEIWFNGAIPEKADEIRRIICSSMANNMFIASATGSGKTLSAILPLALEAFAGLDFVALFVVPTTHLLTQIYHLLLNLFHDVPSVRIFRAMDCLGATLYEDPALLRLDPDIVAALKEHHEVLESTDTNTSMFIDDHLVKRFLDSITKQLATTLPDFRNIIEYGEDRTSYIICGTPGIVSALLTAVKPASGTGIASRGVTSFLKLRHVVIDEADHILLNDNTSFLALIREFFAQRNSTAVFRVPLFFAQRHRLGLPTDRFVFLSATMKYRASLLENMGLHGGCMVDFDEGHARLALSPNVEHFVVQLKRTYSEIDIAYLVFRFLCSPAGSITNSRTTLLPCIVFVNSRHTAQRIAHLLFLMMIKVYKELRYRITLVAQGHVFRRPNFESVPAISNESLEEHPATIVLATDNFARGLDLPAVRSVVNFELPESLATLTHRVGRCARGLNSGVAISVQRSEVEYKFDTLVNFDPSRVVSIDEESLCDYRSTEGPRLSDFSIGDSDVLEISRRFSENMDVYLTTLYDEEFGR
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFDNEWIAFLFYCFNSCLSFRPAEITSKRPVTRKRRVVEVSKKAVRDPRFEAYTGELNEGLFKRSYGFIDDYERSEIAMLKDEIKNEPNSERRAQLQKTMTSKVSRLSTNEIKEKTQKLKREWRKTESAKVQQGKTPFFLKNSELKRRQLVDKFKSLTEKGMDLDKVLEKRRKKNASREHRHIPSQRRSR
The following text describes a protein:
Function:
Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus.
Sequence:
MSLWGQPLQASPPPAVQQPLTASSGPSTAPPAGSTLNRLPEPLLRRLSESLDRAPEGRGWRQLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVPELSDFLQALEHTEVLQLLNPPGLKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPYGNSSELIFNTVHVKDAGFYVCRVNNNSTFEFSQWSQLDVCDVTEVSDSFQGSLDGVSESKLRICVEPQSQKLAPGSALLLQCVAIGSPVPHYQWFKDESPLAHETKKHYTVPYVDLEHEGTYWCHVYNDRDSQDSKKVEIIIDELNNLGRPDNKEQTGQPLAKDKVALLIGNMNYWEHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMCNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGRQALEIRSSLSEKRALTDPIQGAPCSAEALVRNLQWAKAHELPESMCLKFQCGVHIQLGFAAEFSNVMIIYTSIVHKPPEIIMCDAYVTDFPLEHLIFTVCLSYQYSGLEDTVEEKQEVSVGKPLIAKLDMHRGLGRKTCLQACPMPDETCHSSTSTSAGAGHFHSSQDSFHDVYHSQLGNSDSAMPPDRCHCSRTPHAFISNYPPHHYCQFGRSNVPVETTDEMPFSFSDRLMISEN
The following text describes a protein:
Function:
Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I.
Sequence:
MSNLKQKDSKPEVAVTKSVKTYKKSIEYVNSDASDIEEDINRAEDEYASSSGFVNFLRDFKKRYGEYYSNNEIRRAAETRWNEMSFRHRCQYSAEPLDTFHVEPNSVSSLQRSSEGEHRMHSEISGCADTFFGAGGSNSCTPRKENKCSKPRVRKSCPKPRAKTSKQRRSCGKPKPKGARPRKACPRPRKKMECGKAKAKPRCLKPKSSKPKCSM
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSNSRQSPSQAVHPAGTPTSPLTSSSPPFGMAHYASLYHGGASMPPLPPGIPVRSVWEDNLELELRFLHSFVHNARYAAVNIHYPGVIHNGSQKHTSQTADERYSVIKANVDTLKPIQVGLAIYNDFGHIVAWEFNLRGFHPVMDPHAANSVGYLQERGLSQ