lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Miscellaneous:
MISCELLANEOUS: Overexpressed in some cancer lines and some tumor cells.
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Sequence:
MGAERRLLSIKEAFRLAQQPHQNQAKLVVALSRTYRTMDDKTVFHEEFIHYLKYVMVVYKREPAVERVIEFAAKFVTSFHQSDMEDDEEEEDGGLLNYLFTFLLKSHEANSNAVRFRVCLLINKLLGSMPENAQIDDDVFDKINKAMLIRLKDKIPNVRIQAVLALSRLQDPKDDECPVVNAYATLIENDSNPEVRRAVLSCIAPSAKTLPKIVGRTKDVKEAVRKLAYQVLAEKVHMRAMSIAQRVMLLQQGLNDRSDAVKQAMQKHLLQGWLRFSEGNILELLHRLDVENSSEVAVSVLNALFSITPLSELVGLCKNNDGRKLIPVETLTPEIALYWCALCEYLKSKGDEGEEFLEQILPEPVVYADYLLSYIQSIPVVNEEHRGDFSYIGNLMTKEFIGQQLILIIKSLDTSEEGGRKKLLAVLQEILILPTIPISLVSFLVERLLHIIIDDNKRTQIVTEIISEIRAPIVTVGVNNDPADVRKKELKMAEIKVKLIEAKEALENCITLQDFNRASELKEEIKALEDARINLLKETEQLEIKEVHIEKNDAETLQKCLILCYELLKQMSISTGLSATMNGIIESLILPGIISIHPVVRNLAVLCLGCCGLQNQDFARKHFVLLLQVLQIDDVTIKISALKAIFDQLMTFGIEPFKTKKIKTLHCEGTEINSDDEQESKEVEETATAKNVLKLLSDFLDSEVSELRTGAAEGLAKLMFSGLLVSSRILSRLILLWYNPVTEEDVQLRHCLGVFFPVFAYASRTNQECFEEAFLPTLQTLANAPASSPLAEIDITNVAELLVDLTRPSGLNPQAKTSQDYQALTVHDNLAMKICNEILTSPCSPEIRVYTKALSSLELSSHLAKDLLVLLNEILEQVKDRTCLRALEKIKIQLEKGNKEFGDQAEAAQDATLTTTTFQNEDEKNKEVYMTPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRLPRRAKTAALEKSKLNLAQFLNEDLS
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEWWRRWYFLWGGDSVGAAILFYTRLPWPPSWPVNFDRIARWITLMGLLLSLILLALDRGLHWLGMDNLLQSAVVVSLWLALTGGLHLDGVADTADGLAVTNPSKRLAVMQDSYTGAYGVMAIAVVLLLKTFALASFSDHGLASWALIMALGWGRWGQLLAIALYPYLRENGKGAMHKRNLKLRPDLLLGTMIIVFGGVGMGYALAIEPWLILGATGSSALIAWAVGRWFAQQFKGHTGDTYGAVVEWSEVLILLGLSLV
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MTKRKFGLNPDQYKTFRWPCLTGAVSDFCPGWGKSTWATRMSKSVAKITFYDDKNFQGHYYECDSDCVDFHTYLSCCNSIRVTSGAWVVYERPNFSGNMYVLTQGEYPDYHHWRGLNDRLSSCKVIHLMSGGQYKLQIFERGDFNGQMYETTEDCPSVMEQFHIREIQSCKVLDGVWVFYEQPNYHGRQYFLDKKEYRKPVDWGSPCTAVQSFRRIME
The following text describes a protein:
Function:
Catalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of the A-ring sterols such as lathosterone (5alpha-cholest-7-en-3-one) thereby rendering them unsuitable as ligand precursors. May irreversibly shunt sterols away from hormone dafachronic acid production. Dafachronic acids act as ligands and bind directly to the nuclear hormone receptor (NHR) daf-12 suppressing dauer formation and inducing reproductive growth. By reducing the biosynthesis of dafachronic acids, this methyltransferase can regulate dauer larva formation.
Sequence:
MSINMNANFLKLLTHFRRHDLTNFKSEHDTLYEKALETGDHLEVTSHYYSVMSTVIDEYFGGNFHFVPPKFEGQKLEEALKSLHCHIAEKLELSENVHCLDIGCGIGGVMLDIADFGAKLTGVTIAPNEAEIGNEKFANMGISDRCKIVAADCQKMPFEDSTFDVAYAIYSLKYIPNLDKVMKEIQRVLKPGGKFIVYDLIKTNDYDKDNKEHYKTLHHLEYACGMPSLHTQSEVEAAAEKWEMPVVERENLEETYGNRAFHYCFSASPMFMWLVSSPVIDHTIRMAEILRILPAGFKQFNRTFLCGTVNSIVGGGRMGILSGADILLFEKKKI
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAPPFVFPSSLRDLERDTDGDDEPSLRPQNPVAVATLRAADLEEFVKGVSFDLSDKELFCIEEQEVFDSIYSVVRDFNCLPPGLKFNLVETLRSNLSVLLPNIDSLSRASMSSPSDATPITDRIASHRNALKIYSFFLLSIVLMEESAAESCTGAKVTAHGRKKNPVYTWNWEAQRGRILNLIANSLEADLSLLFGPGGTDERYLSFVSKCTFVLYENQNGLKDEDTRNGLCRIIGAIATKHQRISQISASVLHLIHKFDFTVAHLAETVASAEKKFGDGSLAISLIREIGRTDPKDYVRDSVGADNVGRFLVELADRLPKLMSTNIGVLVPHFGGDSYKIRNALVGVLGKLAAKAFKDVEGDNTARLRSKQAMLEILIERCRDVSAYTRSRVLQVWAELCEENSISIGLWNEVASVASGRLEDKSAIVRKSALQLLITMLQHNPFGPQLRTSTFEATLEKYKEKLEGMDPPNPDQDEVVDDSSPGEVVMGQPDSVSDSCVANSQDQNNPDPTIVEITNLEQIRALVASLEAGLRFSKCITSLMPTLVQLLASSSATDVENTILLLMRCRQFQIEGSEAALRKMLPLVFSQDKSIYEAVESAFITIYTRKSATETAKSLLNLAIDCSIGDLAALECLVSSLVSKAEISSSTVSALWDYFCFNISGVKPVQSRGALSILCMAAKSSPSILGTHLQDIIDIGFGRWAKEEPLLARTACLALQRLSEEDRSKLISTNSRVFAALISLTTSFSLPEKIWYGAADKAISTIYTLHPAPEIFATEIAKKCLSSVFSVLRTEDVSNGDETQNDAFLSSLPPSKLGRFLFVISHIALNHLVYIETSVRKIQKQKRKNENSQPISEDPQLDASKSSEAQGINAELGLGATIDIAIESLAERAEKEIVCCSSEKNLIGHCGPFLSKLCRNLTLLQKFPELQASAMLALCRLMIIDPEFCEANLQILFTVAESAPSEIVRSNCTIALGDLAVRFPNLLEPWTEYIYARLRDPSASVRKNAVLVISHLILNDMMKVKGYINEMAVRIEDENERISSLAKLFFHELSKKGSNPIYNLLPDILGRLCNQHLKDETFRNIMQFLISSIKKEKQMEALVDKLCNRFAGVNDVRQWEYISYCLSQLTFTEKGLKKLIDNFKMFEYALSEDSVMNHFRSVISKCKKFAKPELKVCIEEFEEKLSKVHQEKKEQEETTKNAEAHRQRIGSLDEVLASKEVGQSCGHSVEEETSEIVDPSVDGSTEDKENMPECSGNISTENCQTSTSTGSEDGGEEIQSKQPVRKGLSRSRAKKTRDPVVEDSADSAPVRRSTKRQGR
The following text describes a protein:
Function:
A 'suicide' enzyme that participates in biotin synthesis. Catalyzes the formation of (S)-8-amino-7-oxononanoate (DAN-carbamic acid) from (7R,8S)-8-amino-7-(carboxyamino)nonanoate (DAN), a function equivalent to the cannonical BioA reaction and the first half-reaction of BioD. The cellular requirement for biotin is thought be low enough that this single turnover enzyme supplies a sufficient amount of the cofactor. Overall it catalyzes three reactions: formation of a covalent linkage with 8-amino-7-oxononanoate to yield a BioU-DAN conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-DAN-carbamic acid, and release of DAN-carbamic acid using NAD(P)+ (By similarity). Complements a bioA deletion in E.coli.
Miscellaneous:
MISCELLANEOUS: In cannonical biotin synthesis a pimeloyl-conjugate is transformed into biotin by the subsequent action of BioF, BioA, BioD and BioB. This enzyme replaces BioA and performs the first half-reaction of BioD.
Sequence:
MDEINFAVLGTGGIGRRTLEVSTYKDGLTPVAACDRHGVAVNHDGLDVEEILDATEGNIAGDGTGDTEDKRVTDGGAAVKQHGDGAGIVASAQGTSTETPIDEIIAESDEIDAVLLALPNLEHDFIPRIAERFAEAEFEGVLIDVLKRSRVIGMLDDREETLVESGITFVCGAGATPGLLTGAAALAAQSFVEVEEVEIWWGVGLKSGYEDNRGTVREDIAHLDGYDIETAREMDESEIEAVIEEHDGVLEFNDMEHADDVLLERAGICDAEDVTVGGILDIRKDEKPTTTTVRVTGRTFDGKRGTNTFQLDDATSMAANVNGPALGYLKSAVRRNRAGDYGVFGPAELMPGF
The following text describes a protein:
Function:
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
Sequence:
MHAYLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISAFGNWRSEGRYYRPIPEWIAGFGSLSARTEN
The following text describes a protein:
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Sequence:
MTNRGDQKSFVVMVEEGQPGRGEGELSKGAVYKSIYSQDGLDDLHEGMQSTWDSFVKSKEIYPDKKMLGRREMVNGSAGDYVWLTYEEVYNIVINLGAAIRYVGVQPKSKVGIYGANCSEWFMAMEACNAQSMLCVPLYETLGNEAVEYIINHAEVSIAFVQDTKLDLILATLPKCTKLLKKIVSFSTCSAAQRSKAEASGAALLSWDEFLKLGKNNPTDLTPPTTSDISTIMYTSGTTGEPKGVLLSHANILCAIIGYDHFLRERGQQQTEKDVYYSFLPLAHIFDRLTEELFVFLGASIGYWQGDVKKITEDLAVLKPTLFVAVPRVYNRIHAGIFGRINAGGGAKRMMFHYAFDMKLKSLYNGFKHDKAAPILDKIIFNKVKMAFGGNVKCVISGAAPLPSHLEEFLRVVTCAPVVQGYVLNTRQIAKPPDIHDESQRIMFVQSSGLTESCAATFIQVPDVISMHGTVGPPLPNIEVRLVSVPEMGYDALGKPARGEICIRSKTLFSGYYKRPDLTDEVLVDGWFSTGDVGEWQEDGAMKIIDRKKNIFKLSQGEYVAVENLESIYGQCELVDQIWVYGNSLESTLVAVCVPNQPKVEEWAKNNGLMGDFARICRDPKTHAHIMAALNATGKAKKVKGFEVIRGVVLEPLPFDMERDLVTPTFKLKRSQLLQYYKTQIDELYATQKQQ
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Localization:
Cytoplasm.
Sequence:
MPPYTARQILSISSLALAGFGGAYLWQQRQQHRNYFQSQSSPAAPKSSIPKIAGNMASITTPFKTLFAVPMHCESCVNDVSGALYKLPGINKVEANLKDQLLTIEGTAAPSAIVNAIQSTGRDAILRGSGDSQGAAVSILETYHKPTLDKITPAPGASDRMVRGLARMVQVNNSTTLVDLTLRGIAPGTYRATIREFGDLARGVESAGPVWSGTATLTADTKAQISGDPNAPRGVLGTVEINKDGRGSVFLSHPFQIWEVIGHAFAVAPVSVDESAGSTLENDENTVVGVIARSAGVWDNDKTVCSCTGKTLWEERKDEVEKGML
The following text describes a protein:
Function:
Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Mitochondrion. Nucleus, nucleolus. Golgi apparatus. Note=Core component of cytoplasmic lattices in oocytes. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages (By similarity). From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). Expression largely disappears in blastocysts (By similarity). Located in mitochondria and nucleoli in primary follicle oocytes (By similarity).
Sequence:
MKVAGGLELGAAALLSASPRALVTLSTGPTCSILPKNPLFPQNLSSQPCIKMEGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHSFDEDDRYWWKN
The following text describes a protein:
Function:
Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth. Can phosphorylate ROPGEF1 in vitro.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Domain:
The protein kinase domain may be catalytically impaired due to the lack of the conserved Asp active site at position 500, which is replaced by a His residue.
Sequence:
MLTWETPVMLASNTASTKKLAFITTFLIIVLCPVTMVMSQPQADVLPLPASDADCLLRFKDTLVNASFISSWDPSISPCKRNSENWFGVLCVTGNVWGLQLEGMGLTGKLDLEPLAAIKNLRTLSFMNNKFNGSMPSVKNFGALKSLYLSNNRFTGEIPADAFDGMHHLKKLLLANNAFRGSIPSSLAYLPMLLELRLNGNQFHGEIPYFKQKDLKLASFENNDLEGPIPESLSNMDPVSFSGNKNLCGPPLSPCSSDSGSSPDLPSSPTEKNKNQSFFIIAIVLIVIGIILMIISLVVCILHTRRRKSLSAYPSAGQDRTEKYNYDQSTDKDKAADSVTSYTSRRGAVPDQNKLLFLQDDIQRFDLQDLLRASAEVLGSGSFGSSYKTGINSGQMLVVKRYKHMNNVGRDEFHEHMRRLGRLKHPNLLPIVAYYYRREEKLLIAEFMPNRSLASHLHANHSVDQPGLDWPTRLKIIQGVAKGLGYLFNELTTLTIPHGHLKSSNVVLDESFEPLLTDYALRPVMNSEQSHNLMISYKSPEYSLKGHLTKKTDVWCLGVLILELLTGRFPENYLSQGYDANMSLVTWVSNMVKEKKTGDVFDKEMTGKKNCKAEMLNLLKIGLSCCEEDEERRMEMRDAVEKIERLKEGEFDNDFASTTHNVFASRLIDDDDFGFAMNR
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATALQKQLAAIAASSTHQLDLKAQKSAHGKSLLFEPKIAASQSFETVYLICYEGFRDLCALDSRFLQFSKSLFSEQSKVEDRTQMTKEENKKLNAVVEAFITLVVNTPGFFNALQAHTVRVVKAGHQAPQMISFWSTITLEAVFGILENTSSGRRDIQSQKTEELVLRILPVLNSCMQAKYGAETVAACYSIVTVLAGRGELGEKVLDGLMEAVVLAHEADSLNACLQCLAVLAEQRSPAQLPPRVIRRLLKVPQLSQKLVQISKQCRVHRLTLGCALGALASIDRLEEQRDVFQELMASGLLTEAYTRAALAALVTSIRDSAPGSTEHGQLLDLAAQLAETTYFLDGMRAAAKSDNVDLESLGLTLAPALETAQIDNDEDEDMLDVDDVSSQAIAAPKVEVPDFAVQSFLELDASQSFAEVANAFERAVSTHQSSPFLASKSLGKENAMHSNLYLSLLARIWCSSQLPAARIAALRAAAATLKSAEDTCDFQNLIPYLLHALADPSAPVRRAAAACTVALSEASGSQANTSTWGSSKLYGSSGKAQKHVSQVVQLKSEDVSTLLSSILIPMLEESVMDPTFAIPAIREVLEGSKGSKSQPKHGMNAQTRTYYRLSFFASHLSLSPLVRIRIILFPIFNFSGKVSDTVRSNTILPLIQGWCTLPLAEASKVCDVEKVTLEDAYRGHLNALVAREAKSVQLLNELMIESLDSSKRLLAEAVFDKVAAVWPATKSEQRVTLARTLLDMSFKEGKDDGEKQCRERAIEILRNVKHDSATLLTFLESVPAAVQMPEGPPTKKRRRTSRNEMARVELASQDDVQRFVAKADFGFFELIEGSNPGQPSQPFSRVYSLSSTTWQPLKQQSGSELVYVQSMILGSLTPIVDTLKVSDLVVHGFMHANTVQQQKDTADYQSSVRADLLIDCIRHSTSPQVQNSALLLIANLASWVPELILHNLMPIFTFIGSTLLRQQDDYSAQVVDKVWCYHFTQTISRVVPQLAASLRAKHKNFLTGVSDLLLSFTAAFEHIPLHRRLKLFSELARTLGPQDSLSAIISLLADRYHNGKTQRRFSTELLLVFDPIHTLDAIKGYLDLVVDAAGPKRKVSDSLFGLNDKTAAQVETAIKNLLVSLADLATDDRLRAHVTRAFRRKDDPARPREVFANIVETTIQLSKKVASSPKLYEACSRVLANCLDLLPTTDLVKSAELLLVNTDHQVQIAAIKAVELRAGNAVQNDKKSVISLISFLPSVEKVLQQSQHTDAKIISVGCIDRIVERFGKKDMTAVASIAQTIAGSQALSSGNDTIRVLSLLCLTSIVDVLEDEAIALLPTVLPTAFDYLSQAIEGEKNGLHNAVYSLLSNIVERLGYMFSRDYLETALRLSHRSAVGGLEDTCDESRRTFYQNVSEHLGAQETFAAIKTTWPHALSQGFEASSEHLELLRSTVDLQSKSKLIKASSTLSEQAIDSQEEQEYDDEEMNQLDNTLMSRTCHGSEAQRCPPSGPFFVQLVDQEGPMSAKPEYAVTFYKFLAAFFDKFKSDCSRATQATSSTTQPKMLEHVAQEDADSELRSAVLGALQKSFQHDQDAFWQAPSHFGTILKPLVNLLTISATEEVTEVVIPTITDLAASSSSSIDNHRELNTILLRYMRSDSAATRLATVKCEQSLTTRLGEEWLGLLPEMLPFISELREDDDEMVERETQRWISQVEGVLGESLEGMLQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Major transcript; MISCELLANEOUS: [Isoform 2]: Minor transcript; MISCELLANEOUS: [Isoform 3]: Minor transcript.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MYFCWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTASFLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEALSVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGFVSPMLTQS
The following text describes a protein:
Function:
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type II membrane protein.
Sequence:
MAPKKIGAGKGDSSILAKISNYDIVSQGRRAACDAVYVSKKLLKSTGKAAWIAGTTFLILAVPLILELEQDHRLGEIDFEQASLLGTPPVGAML
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MFWRNRPCVVVGISQNHYLECNLPAMAARHIPLARRKSGGGAVYHDEGNLNLTFLTPKPAYEPGRNANILAQALQDGLGVPARVMEERNDIVVDGHKISGSAYRIGRLAAYHHCTLLVSSNLGNLKNVLRSELAPYIVSKGVPSVRHLNGLMGDHPSSPFPGPFSSVTLSNPSRFVLFILQTDRLTCRLALGRRRKPCSFLAFQNENKPKKTDLMKIFNLPQRPPMQILYKKLLQRMLQVAVNLPLCVCEKEERQRDRERERERESSQAEAALRADGDATLQAFRASNDESLRIGQYRTSEHLMAYLFHAYRMDGCDSHEAVVERLSADSTPSGLCGYVFQDQDPTYTCVDCAVDHTCVMCHDCFHKSIHREHHYNVYMSGGGGCCDCGDSEAFTSGYACTQHQVDESQQQSPATLCQNHPRPLLESLVERLGHIFTLAERYLEDTEGPSREASCLVVYNDELHDFVQVIEILSLATHCTEARARSWALLIDEIGRAVILLGTPGQCEQGSEIITPSHLVNYVSSISHISRQECMVDVLMRLADMCKQSTVMRHVLGGVLCGQTLDAILADTVTTSSLDDSFLARHMRTQAAFWKESRAAYRALIFAAPMVEHNYKKFLGLCLCKNYTVLHQKRAESAEGDDESLMQLSVQVFTTPSVTTELVYFHNAFDYLLDTLNKLFEPFWDPRDGRYNCRVPERMAHTFHDQYATIIYDISYALKADLGTLDMLLPRYERLSWRHAFLIEMTLCSKLLQSLLDYGKQHPQHVLYGIHALGRDFRQLCCVQPMQPMPSNLKLPELSELLAQSNIRMWVRNGNAIPNQLFNYSASDSKGWLYDKDLRVLQLVAANVPADVFVWQTLLRFELHTWALKVGAETSGEMAAAVASLFESYFRLILNILTCRHHEGVGDVTLEDIIEFQVIQALCCGPAPYSRIKRFFPRRYDRDGSLTRMLARVANFRQAEGLREQSTYELKPELASLYDPTTSFLLPENHNDAEQYLLRLSGSRSSLFDEPFGLKRPALLPQFSQLESLVFDRDSYANSPGVVLLPYMPVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLVLGKLANENLVQLVLQFFVVGLSPSESTNSSAPTALQFAERVRIISLELPEPEQGLDIVELLEAVAQTHLCEATGETKKKKKKKDKAKSRQQKLMAHFAAMQTSFAETVEDEDDEIPIDGTPMPPGGDYVYRVPFLILQTDTAEAHELASDVGQDSHSRSFLILIHYNAPRVSDLLSGTFSRHGEAVFKSCGHAMHYNCLEEMLKNQREQDARFLAPDTLNALAGDFSCPLCRSVCNTFVPAVAPSIVRTCVPVQSEAAESGSCDTLLATLDKAEEELHQMRIHSAQLMDDVQGQWRARFENHAEPTPESFRRPMDSLEGLAHLAPETDSHRQALRAHFYSAATLGFQTSRLPNVMTFQKDGLWAPWTAFFQTMSCTELQLRSRRETVMTKQQFAAIERLFQGNLALTANMCILGDSLAYLKLARNMLNSTVAIPASDNLGRSQERVHLTALDPLRLVYTLVTVCIMTKQPVPWASLKEFALVVSLVRVMSTQPLDDCEEAEDSAFGEAMDDDLATAMAQFGRALQLDNVSTTLSPSAARRLLQQAAPSLRSLLLLETLLQAGKLLQSLQLDVGRLGARIEVGMEGHGWYGLAQYLKSFLFGVSPHMRLLPATQLHLVKVPPTFNELFLDAKKALCPTLHTPAKQQVLCLLCGAFVCAQGPCCQGRYRIGARDMGSIGACFRHTITCGRGTGMFIFVSKALVMLINGEAGTFLPAPYVDAHGESSTALLRSAITSFDPTRFQALEDMWLRHEVDRETMRERRPQDFTFW
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that facilitates microtubule-kinetochore interactions and the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MKSDLDGYEVRIKSLENQTAHYSEQALLEQEQRVLASLREITQNVIAMGQENSLVEIKGELESKEESELVIDPSGFQEKIDTFVELVELLKVTHLEQETLDNFLRYTISSSNLLQINSVQDAKYVELESQVKELEQGTLESHKREIEATKGQIKNLCQELSMAQDSINETFLDTSNALEECDALLNELTQLRMEKQTSEEADTIEDDPVSQTYEDWESLQKSKLELRLLEEETSRLQSRVESYEDYQKRSRQLSNNDPRMLQNHKALELLVELWMTKFLPQPGISHLELFPQSRKFQFDVEPTFTVVITLADQTTFQNVQVYRKDAKSLVMDHGLNDEIKNSYLGTNNIYNGLNDIIHTLQRRVQAKGSN
The following text describes a protein:
Function:
Part of the ABC transporter FtsEX involved in cellular division.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSANDLPRGPEEGAPERKTREKPSQEQTDWSGSFSAYLESHRASLVDSLRRLFGHPFGSFFTCLVMGITLSLPMGLSLLLNNVERLGGSWQRAAQISLFLDLKTSENQGQDLREQIERLPDVIEAQLISREQALSELQEQSGLGEALKELPENPLPPVISVTPKQIDRAGLEALRQQLAELPHVQQAQLDLVWVERLSAILKLGERFVFGLTILLVLTLLLVVGNTIRLHIENRRNEIEVIKLVGGTDGYVRRPFLYMGALYGLGAGILSWALLAYSLNWLNGSVVNLSGLYGSDFGLQGVPLDDGLSLTVGAVLLGWVGAWLAVARHLRELAPR
The following text describes a protein:
Function:
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
Subcellular Localization:
Cytoplasm. Secreted, extracellular space.
Sequence:
MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Sequence:
MDDHIQQAWQFYRNLGSPKFICAPMVDQSELAFRMQTRKYGTTLAYTPMLHSRIMTESKSYKDEFFTTCPEDRPLFAQLCGHDPQVIIKAALMIQDQCDAIDLNFGCPQGIARKGLYGAFLLEKREQVLTIVKELKQNIKVPVTCKIRVFKDRKRTLDLTKDIQSAGCSILTVHGRTKEQNKDFVGQCDWNIIAEIKQLLQIPVFANGGIYTWSDVERCLQETKVDAVMSSEALLENPALFSGEIKDLNELALEYMQLAKQYDARLVEIKAHLFKLLYTGLQIHTDQRSKLAAAKTYEEHLEVVIELKNKRADIPKEDKLGWYKRYQNFKQPNQKDKEDDKQENIIQEQDLLLQNYDS
The following text describes a protein:
Function:
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Perikaryon.
Sequence:
MQPQRDLRGLWLLLLSLYLLLFEVARAGRPVVSCPAACLCASNILSCSKQQLPSVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTHLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSELQALEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLLDLQKLPAWIKNGLYLHNNPLHCDCELYQLFSHWQYRQLSSVMDFQEDLYCMSAKKLHNVFNLSFLNCSEYKERAWEAHLGDTLTIKCDTKQQGMTKVWVTPSNERVLEEGANSTVTVSKDDGSLHFQRVQVEDGGVYTCYAMGEAFNETLSVELKVYNFTSHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLDPAGSGQNGKLKPGNTLPVPEVTGKGQRRMSDPESVSSVFSDTPIVV