lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Lactone hydrolase that is required for the degradation of monocyclic monoterpenes such as menthol and carvone. Catalyzes the ring opening of lactones formed during degradation of monocyclic monoterpenes. Can hydrolyze epsilon-caprolactone, the lactone derivatives of dihydrocarvone (4R)-4-isopropenyl-7-methyl-2-oxo-oxepanone and (6R)-6-isopropenyl-3-methyl-2-oxo-oxepanone, and ethyl caproate.
Sequence:
MSATDTARAKELLASLVSMPDATIDDFRALYEQVCATFELPDDAQVEPVDANGADALWVSAPGVSADTVAVVVHGGGFTMGSAHGYRELGYRLSKSGNLRALVVDYRLAPESPFPAPVDDVVAAYRYARSLDGVENVFLVGDSAGGGIAMSALITLRDAGEQLPDAAVVLSPLVDLAGESPSLVDRAHLDPLPAAVLVNGMGGLYLNGLDVRHPVASPMHGDLTGLPATLVLVGTDEGLHDDSTRLVDKLKAADVEVQLEIGEGLPHIWPIFSFHPDAVAATDRIGEFLRSHVAAPR
The following text describes a protein:
Function:
Virulence factor that affects the acute immune response to infection. Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation.
Subcellular Localization:
Host cytoplasm.
Sequence:
MATKLDYEDAVFYFVDDDKICSRDSIIDLIDEYITWRNHVIVFNKDITSCGRLYKELMKFDDVAIRYYGIDKINEIVEAMSEGDHYINFTKVHDQESLFATIGICAKITEHWGYKKISESRFQSLGNITDLMTDDNINILILFLEKKLN
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Lysosome.
Sequence:
MESKAFNKPKVELHVHLDGSIKPETIIHFAKKRQIKLPADTVEGLLEHVSYKEPLSLTEFLQKFNHYMPAIAGDREAIKRIAYEFVEMKAKEGVIYVEVRYSPHFLANSKVDPIPWGQKEGDITPDEVVDLVNQGLRKGEKTFNIKARSILCCMRHMPNWSSEVIELCKKYQNDTVVAIDLAGDESLNCESYPGHRKAYEEAVKCGIHRTVHAGEVGPPSVVKEAVEVLKAERIGHGYHTTEDPNLYKELLENNMHFEVCPWSSYLTSACHPDFTKHPATQFRKDKANFSLNTDDPLIFGSTLDVDYSIAVQHMGFTEDEFKRVNINAAKSSFLPDNEKKELLYKLYEAYGMILSTGL
The following text describes a protein:
Function:
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MEVMSVIPYVIEQTGRGERSYDIYSRLLKDRIIFVGTPVESQMANSIVAQLLLLDSQNPEQEIQMYINCPGGEVYAGLAIYDTMRYIKAPVSTICVGMAMSMGSVLLMAGDKGKRMALPNSRIMIHQGSAGFRGNTPDLEVQAKEVLKLRDTLVDIYHKHTDLPQEKLLRDMERDYFMSPEEALKYGLIDQVIDQTRENRGGEE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MGSGSGESSNGDSQSCLVGGSSSNREAGNFQCNICLDLAQEPVVTLCGHLFCWPCLYEWLHDHSRSSECPVCKATVAEEEVVPLYCGGNSSAHPQSRSTTRVDIPSRPAAGRRLATAPQLPSDANHIYHHDMNHIHHTAGWTPATALQPQPDLNYIYHRNMNHIYHHEPWVMASNHLAGTRLGNFTFPNAPANHSAAARNQMASINQRNFMFQDATANDVGHGSHANVFHSLPAHGFHHGHGQHSYWFHHGHGPRAYGFGHAYGLWRHANRGRQVDVMWNLLLFLFLALIISNIIS
The following text describes a protein:
Function:
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
Subcellular Localization:
Secreted.
Sequence:
MKVLFLIGHILLAMVCFSCEKQMERPSELEQQPPGQPPVQDVYTRYTRQIYVPILYAPKTSIQYPYFSKLAWQRPYAAYIPLLSSRYPWPVIPRSPHPSFAFNPPQYARVPAPSGPTSSPAAPMETTTIPSTSTVAATVTPDATSKFVTTEYSTTATIPTSPIPEQQP
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Sequence:
MYVIKRHGRQEPVHFDKLTATLKKLSYRLSKDHCDPVLVAQKVYTGIYQGVTTTQLAELAAETAASLTANHPDYALVSFFLFLFLVLASAFKWTWPFTWIGSDFVCVCSTDVEEQLAARIAVSDLHKSTKKSFSETIQIMYNYINKKSGKVVPLIADDVYEIIMKHLMLLGWTVRSYMTDFEYDYFGFKTLERSYPLKMDGKVVERPQHMLMRVAVGIHIVDIDSAIKTYHLTSQCWFTHATPTLFNAGTPQPQLSSCFLLCMKDDNIDGIYDTLKKCAVISKSAGGIGLSIHNIHATGSYVCEENGTSNGIIPMLRVFNDTAHYVDQGGGKRKGGFAIYLEPWHADIFEFLDLRKNHGKLLLNALWVPDLFMETVQGDGKWSLFCPSEAHGLADCWGEEFKRLYTQYEKEGKARMLIPARKLWFEILNSQIETGTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEVIEFSSPTETALCNLASIALPRFVREKGVPLESHSSKLVGSRGWKKRYFDFEKLAEGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSQLAGKDGPYKTYSGSPVSKGILQVDMWGVTPSDHWDWDGLREMISKNGVRNSLLLAPMPTASTSQILGNNECFEPYTSNIYSRRVLRRSKPMVEGSINKGSSFYDTKLNLKTH
The following text describes a protein:
Function:
Important role in the capacity of milk to transport calcium phosphate; Casocidin-I inhibits the growth of E.coli and S.carnosus.
Subcellular Localization:
Secreted.
Sequence:
MKFFIFTCLLAVALAKNTMEHVSSSEESIISQETYKQEKNMAINPSKENLCSTFCKEVVRNANEEEYSIGSSSEESAEVATEEVKITVDDKHYQKALNEINQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEENSKKTVDMESTEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQHQKAMKPWIQPKTKVIPYVRYL
The following text describes a protein:
Function:
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVSKLTSLQQELLSALLSSGVTKEVLIQALEELLPSPNFGVKLETLPLSPGSGADLDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQNQGPGQSEDTCSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHNLNPLLTHGSPHHQPSSSPPNKMSGVRYNQPGNNEVTSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHSLLSPDSKMQITVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQGVPVINSVASSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSINTLTSMSSSKQCPLQAW
The following text describes a protein:
Function:
May play a role in the regulation of the cation channel TRPM8 activity.
Sequence:
MKVLEDYRSLVHGIGSLDFSGDAVPCKLLLTGDTAFPVLVTPRKDVLIAASRYGKGKVVVMAHESYLNTNAFMDFLKNAVSWLSPNSEANIGVHKGLNLLTDNLSANGSKVQNTSTLIEGLGVFCTIGYDDSQDKQIISFVREGGGLLIGAQAWHWSYSHKQENVLHHFPGNKIISVSGVHFTSDYGEKGNICVMENIPQAPIYTSFDFSLDQKYLLKGMSQLDISGSSIPSDLLLHGTLSFPVGLSENKQCFLGATYYGKGRVVVATHEGYLSKSELKTIMLNAISWLDINQNRRIGVHKGLRQFAELLQKENIPCNISSLDPDLSVYCCTSYSDAEAKAIHEFVAEGGGLLIAGHAWYWSSQNSDLDVLIQYPGNKILNKFGISILDRTIPGGNYNAINPDESSQQYHFRRGLCNLQAELRSGAEVKPPLSIWMNKLRQDVTAFMRLPANPIISSIQSQFVEMMQICEIPNVTKQCPVSSCSKEAFILCLAQECFNVCDESHILEKEPSITVEIDGTNPGNNAWRSTGLYLAPRKTAVLEFPASAVHQGLQVQVGCQSDDLSSADKYCRAPVVVRRFHVDSQRVSVSCFWGGLVYITVKANSNLGIIPVKVYEAEPAPIYIKGKTSLDTWIQSIRNLPAPWAELITENIILTVPSDAIRSLSDPEALLSLWDKIMVAITELAAIPKKLPRPERFVADVQISAGWMHAGYPIMCHLESAKELTDLNIMQTGGIWGPIHELGHNQQKTNWELPPHTTEATCNLWSVYVHETVLGIPRSQAHCCLQAETRANHIQEYLRNGSNIEQWNVWTALETYLQLQEGFGWEPFKQLFKDYQSMSGIRNENKSKMNLWAEKFSEAVQTNLVPFFEAWGWPIEEATHSKLSVLPVWEKDPMKSYLSARKSNSN
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase that may regulate the response to iron deficiency and thus contributes to iron homeostasis.
Subcellular Localization:
Membrane; Single-pass membrane protein. Nucleus.
Sequence:
QFNELRCLIESIQSTEISSISAAEFFSKLCSQADLIIETIKRHFYNEEVQVLPLARKHFTPDRQRKLLYQSLCLMPLKLIERVLPWLVGSLSEDEARNFLKNLQLAASAHDSALVTLFVGWACKGRTDGVCLSSSVTGCCPVKRFTDIEESYIRAPCLCLLSVNTDDSKRPSKRNLAVICTKENTSDSSKGVNACNISCNDQSCCVPGLGVSDNNLGRTTISTPKSLRSLTFSSTAPSLDSSLFIWETDCTSSQPNHKVHPIDTIFKFHKAIRKDLEYLDVESSKLSDRHEAFLRQFIGRFRLLWGLYRAHSNAEDEIVFPALESKEALHNVSHSYTLDHKQEEKLFEDISSALNDLSTLHXLHEGLKDDSMGLSDRDHIRKYNELATKVQGMCKSIRVSLDQHIFREELELWPLFGKHFSVEEQDIIVGRIIGSTGAEVLQSMLPWVTSALTQDEQNKMMDTLKQATKNTMFSEWLNECWRRTPEISAQPEALQTSNTNRGSVVDSHEGLDQSDHMFKPGWKDIFRMNQTELESEIRKVNRDSTLDPRRKSYLIQNLMTSRWIASQQKSQASTEEVSCSEDVGCSPSFRDPEKQIFGCEHYKRNCKLRAACCGKLFTCRFCHDEVSDHSMDRKATVEMMCMRCLKVQAIGPSCTTPSCNGFSMSKYFCSICKFFDDERPVYHCPSCNLCRVGNGLGIDFYHCMKCNCCLGISLKEHKCLEKALEINCPICCEFLFTSSATVRPLRCGHYMHSACFQAYACSNYVCPICSKSMGNMAVRISYSGAXLANEVLPEEYQNRWQDILCNDCEQKSRARFHWLYHKCGSCGSYNTRVVKAPATYSDCPTSNGGGVRSEE
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MSTNRRLRQYYGLETSETNNETDIDSPNFNSDKYFAENTKNESIHNIIATQNQIISEIRTYENELQTIVYGNYQKFLHANDAVSEFKEQIVDLRAQVDHLKEHFTEMQKKNNEIETKYGKTKEEVVSLTGISRLLERVKFIMNLPKELKNCLKTGNYKKAVNIWLKVEKILTNNSNIPSFQGIHSTCTEIMEKIKSEISSHMVNTDISVSESIEYAILQVRLGYSLQLICSSLAFHEYLIIDNRLEDDSKPAGPIELLEQVDQLAIHNATEFVSLFKEKLIPLENENSEKISKVLSDFTSNTFERVCKFVSSGVNLTNLSVDDFFSYLNKFDTLLTPIATSKQLSDYTHNVIVKYIEGVTEKIYQTTVEFLNTNIKSNADDLSKSVTEPILNLISQFAPYSANYGECVMTLAIQIQLSLIKLFEVFRSTPGDDVLALSKVAQRLSEGEIKGIYSRISDIEQGIPSLSDELTVAAKRTSEQCLLAFITAARQQIDLQLIKDMSDYNSYPEEEPISPSQAAINLMTTLKDYSQRVAALFNPADYAGTSSPRKTVVSSSNVATFNGVRDASDISQMFHQATFGRLFLNPKISMDPAEIIFSLIIYSVKSFLEFVRNMTYSKYGFHQVQVDCFCLSNIFQFVDKVGFERIDSERTGIVTFVLEEAAYSAGDRTYDRDPLQLTALHSIWDVYMEKHQ
The following text describes a protein:
Function:
Catalyzes the second step in the shikimate pathway.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MEAVVASVSCRSFSTPISSSSSVAADVDRRCPPSSAGSRVVCSQSLQKDFGRLHLRSSQFLSGTDIGASAPAAGATHGRNFSMAIRANAAQVLNDVASPTKEETTVVNVDLGDRSYPIYIGKGLLNEPELLQRHVHGKKVLVVTNTTVAPLYLSRVVAALKHGGNNVQVESVILEDGEQYKNMEVLMKVYDKAIVTRMDRRCTFIALGGGVIGDMCGYAAASYLRGVNFIQIPTTLMAQVDSSVGGKTGVNHPLGKNMIGAFYQPQCVLVDTDTLNTLPDRELASGVAEVIKYGLIRDAEFFKWQEENIDRILDRDTSALVYAVKRSCENKADVVAADEREGGVRATLNLGHTFGHAIETGTGYGNWLHGEAVAAGTIMSAHMSLKMGWIDDDLFKRIYNITARARLPLRPPGSMDVQLFEDIMAVDKKVADGLLRLILLKGPLGNCVFTGEYDVKALDDTLRHFCRA
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKLKVSA
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This isoform may play a role in regulating the transport, accumulation, and compartmentation of zinc in the hippocampus.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCATGGSCTCANSCTCKACKCASCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MLHCTQVCLSALTKRTHRVKVQVLKDFPRFQLYKGQVANVKPSLMRNYLHNFNGAKYILSEEHDINTELLKQYQTLEAKLEEDHQQLSKRHETEVQKNMELRKESVFGHKKEEKPKEEKKGLLDSGITIEEVKIPGLDI
The following text describes a protein:
Function:
Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.
Subcellular Localization:
Nucleus.
Sequence:
MKTIKPLPEGVRHSMRSGIIMFDMARVVEELVFNSLDAGATKVSIFVGVVSCSVKVVDDGSGVSRDDLVLLGERYATSKFHDFTNVETASETFGFRGEALASISDISLLEVRTKAIGRPNGYRKVMKGSKCLHLGIDDDRKDSGTTVTVRDLFYSQPVRRKYMQSSPKKVLESIKKCVFRIALVHSNVSFSVLDIESDEELFQTNPSSSAFSLLMRDAGTEAVNSLCKVNVTDGMLNVSGFECADDWKPTDGQQTGRRNRLQSNPGYILCIACPRRLYEFSFEPSKTHVEFKKWGPVLAFIERITLANWKKDRILELFDGGADILAKGDRQDLIDDKIRLQNGSLFSILHFLDADWPEAMEPAKKKLKRSNDHAPCSSLLFPSADFKQDGDYFSPRKDVWSPECEVELKIQNPKEQGTVAGFESRTDSLLQSRDIEMQTNEDFPQVTDLLETSLVADSKCRKQFLTRCQITTPVNINHDFMKDSDVLNFQFQGLKDELDVSNCIGKHLLRGCSSRVSLTFHEPKLSHVEGYESVVPMIPNEKQSSPRVLETREGGSYCDVYSDKTPDCSLGSSWQDTDWFTPQCSSDRGCVGIGEDFNITPIDTAEFDSYDEKVGSKKYLSSVNVGSSVTGSFCLSSEWSPMYSTPSATKWESEYQKGCRILEQSLRLGRMPDPEFCFSAANNIKFDHEVIPEMDCCETGTDSFTAIQNCTQLADKICKSSWGHADDVRIDQYSIRKEKFSYMDGTQNNAGKQRSKRSRSAPPFYREKKRFISLSCKSDTKPKNSDPSEPDDLECLTQPCNASQMHLKCSILDDVSYDHIQETEKRLSSASDLKASAGCRTVHSETQDEDVHEDFSSEEFLDPIKSTTKWRHNCAVSQVPKESHELHGQDGVFDISSGLLHLRSDESLVPESINRHSLEDAKVLQQVDKKYIPIVACGTVAIVDQHAADERIRLEELRTKVLAGKARTVTYLSADQELVLPEMGYQLLQSYSEQIRDWGWICNITVEGSTSFKKNMSIIQRKPTPITLNAVPCILGVNLSDVDLLEFLQQLADTDGSSTIPPSVLRVLNSKACRGAIMFGDSLLPSECSLIIDGLKQTSLCFQCAHGRPTTVPLVDLKALHKQIAKLSGRQVWHGLQRREITLDRAKSRLDNAKS
The following text describes a protein:
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MLRYPYFCRMYKECLSCWLESGIPNLGVWPKRIHTTAEKYREYEAREQTDQTQVQELHRSQDRDFETMAKLHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSMQLDTPERGSSLRKDGPLDIRMDGGRNISSLCYLYTERLTTAIYLYCHQDFPGSSHICEQ
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MGIFLLLKSFIQSFAIFVLLITNILIIFLVKTKSPTKMGSYKHLLCYFSCLSMVYGVLEYFIEPYIFSDAVSGVLIMDLRGSAFELYPKISLFLIVGGTSCFGVTIYAIAINFIYRYFAIQRQGRLRYFSGKRIIFWIFISLLGGIISSSLFLTLGPNDEMTEHLRINLSKLYNLDVDRISYIGLLFWTTRSGNLHLRLEDLLKYFALKGFMMIPFCIIIYCGVMSYLKIKNLNSQGESEFSKRLQVQLYKALIAQFLIPMLFLFLPTSTFISCPLFKLDISWMNRIITILYSFYFALDPFPIIYLVDEYRKAVLGFFRYIRRNHQVSSVIMNVSNLE
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MALTVMNCCKSDSEVQMLVFIYICATFYIGQLNTFKTLLLKTVDPYADVAEADVIAAEPESIRKWREEYAKRIEEKDESARTEQQEWKDKAKEEVEEWYSRQNDQNDKIKKSNREAEEAFVNERDSIVPGHEWEKVANLCDFTSKSYKCTKDTSRMRSIILQLKQSPLKRESKALCASAE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that acts as a negative regulator of abscisic acid (ABA) signaling. Mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ABI3.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDASSSPSPSEESLKLELDDLQKQLNKKLRFEASVCSIHNLLRDHYSSSSPSLRKQFYIVVSRVATVLKTRYTATGFWVAGLSLFEEAERLVSDASEKKHLKSCVAQAKEQLSEVDNQPTESSQGYLFEGHLTVDREPPQPQWLVQQNLMSAFASIVGGESSNGPTENTIGETANLMQELINGLDMIIPDILDDGGPPRAPPASKEVVEKLPVIIFTEELLKKFGAEAECCICKENLVIGDKMQELPCKHTFHPPCLKPWLDEHNSCPICRHELPTDDQKYENWKEREKEAEEERKGAENAVRGGEYMYV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MTGRITNSNRWRRRLQLNRMSRNSRRQKYWANYWHSYNHQYNQSKIRRFRKQKIMRSSFTFNNQQLLQKVPPIQQSMRYGNKAFRDWLDQINPIVDDYLKKQLPQNLQNAAVELRSYLLDSFGNKQRIDYGTGHEFQFFLFLFSLFRLGIYTEKDYEGIVRLAFYKYIDFARKVQMTYMLEPAGSHGVWGLDDYQFLPFVFGAAELIQNDDGLLPDSIIKENVIKNYKAEYMFFQCIDIHQQCEKRTIP
The following text describes a protein:
Function:
Required for male and female gametogenesis, seed development, and embryo and endosperm development at early stages. Involved in the establishment of bilateral symmetry in the transition from the globular to the heart embryo stage. May act in the frame of a CRL4 complex. Required for proper vegetative growth and organization of the adult plant body. May play a role in hormonal control of plant development.
Miscellaneous:
MISCELLANEOUS: Plants with a weak allele homozygous for WDR55 display pleiotropic phenotypes in the seedling and adult stages.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MEIDLGANAFGIDFHPSTNLVAAGLIDGHLHLYRYDSDSSLVRERKVRAHKESCRAVRFIDDGQRIVTASADCSILATDVETGAQVAHLENAHEDAVNTLINVTETTIASGDDKGCVKIWDTRQRSCSHEFNAHEDYISGMTFASDSMKLVVTSGDGTLSVCNLRTSKVQSQSEFSEDELLSVVIMKNGRKVICGTQNGTLLLYSWGFFKDCSDRFVDLAPNSVDALLKLDEDRLITGCDNGIISLVGILPNRIIQPIGSHDYPIEDLALSHDKKFLGSTAHDSMLKLWNLEEILEGSNVNSGNASGAAEDSDSDNDGMDLDNDPSKSSKGSKRKTKSKANTLNATNNFFADL
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKTSQLKRLKETLKKNDLTGQTNVKGNKKKMNSGKNRQDRDKVLSDIRQQFNPFDVKVARKKHDIGGRTVRGSVGRPGLSKLSGEEARMEARKLELQNKGRVGGVFDRRFGEGDSNMNPEEKMLERFTRERQLRSMGGGRNKSIFALDDDDDDADADMMLTHSGQALDFKDDFDQGDLGIEAEEDEEMAAILANRRKLAEERGMGAMGVNLEEMDGVDMEEAGTGRKKSKEEVMKEIIAKSKFHKAERQAARDKDQAIIEEMNDEDTMNALIRELGSIKAKKVVTALDQKEKEYDQNFRNMILDRRAKPQDRTKTDEELAKEEAEKLKKLEDERQARMRGEVAIDQGEGDDLDGNVAFDFENSEEEGEDDEDEAEDDDDEDVEIHEVDEDEDESGDKSGDESGEEETTKSEPASKSSSSTLAYTFPIPKSHKMFLETTSAYPLDQLPTIIDRINVLHHASLKEGNKERLAKFACVLIDHLMYLADEEEEDDFECLSEVVAKVHTLAETHSPTMAAHIRKKLEAHQADTTVTAGHLMLWTLIGMIFSTSDHFHLVVTPAVLVMTRFLSLSTFDSIPKCIAGLYTAQLLIQYQRIAKRFIPEIAVFLGRLIAALEGTETSLPMASLFKIAPIKGFTPGKASHKSTDKTISMRSANRSILSKKEVATLSQELHNQAVFSVSKLMDTYKDISAFPETFEFCENIPELADKYSRITKFKLADRKPLTLHKHRPLAIKTMAPKFEENFNVDKKSYNPDMALQETQKLRAELKKEKKSALREIRKDAAFEAREKIRERREKDDAYHEKMARLVRSVQTEEGAEKNAYERERASRKRKR
The following text describes a protein:
Function:
P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation. By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning. Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis. Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain. May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole.
Subcellular Localization:
Cell projection, dendrite. Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Postsynapse. Presynapse.
Sequence:
MIPFIEEYVSLQAFAIISLGLLSTPLTGFLAYCLYLFYVHCQYAHIPGPKRDSFFAGNVPSIQYEINVKKRGICELWSEWYNQFGGAHIFWVYHVPVLVLGHPDDVKKVLVTWNLPKASRLYKTISYCYGERFAGEGVLTELDHEVWKRKRALLNHAFHRKYLRNLMQAFNESSNEFLKRIGSLADGKTEVRMADEFAKVTLDVIGKVGFNIDVNSIGDENSPFPSAITTALDGLQKGMRNPFWKFKFWTFSYQEKVKSAIRFLRKFGQSVIMERNTAIIEGLESPKDILAHILQMGKENADYTLENMTDDFITFFVAGQETTSNQLSFTLMEILGDSSIENKICNEVDDVLGSRQYVEYQDLGKLEYVGMTLKEGLRLHPPITGTQRILPFRETLGGYNIPANTPVSVVYQITHCLEEFWENPLVFDPERFSSKNKSAISTTSFLPFCTGPRTCIGKTLAEFEAKLLLARLLQEFKLKLVPGQTKQILEQLTVRPRDGVICTITRR
The following text describes a protein:
Function:
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
Subcellular Localization:
Mitochondrion. Membrane; Multi-pass membrane protein.
Sequence:
MKLSTPEEVKAFNRNTYSALFKGALVGSSLGIAGWLIGNRYSAGFRRLPFSLKSWLVIGSGSGASIIFADKAGLKFEAERYGKFDQIDYSTKGLPWNQRALYYFNEHKWPIILGTWASTMGLSLYAASRNRYDTAPQKLIQARMYAQGVTVVVLLGSVYLSTLANRLEPLEREVLVTDPSNPTKLVAFKQRKERYPGELQWEVLVSQDEERLRKLNLPLREPHGSTGPMSTPTPALNSSRSA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAPNVSTKRKNLSMEDKVQVIREVERGKKKSAVGRQFNLVRSTIHRIWNDRERILSAFEQEGPKAKRLRKPARGDVTEALAAWVRQQRAADVPVSRPRLVVKARELAAALGDETFVCSGDWVRRFQSRHDVRLAPGGGAGAGGPGAGGEWAAAVWPSLREGFGEGDVFCADETGLIFGTTGDGGRPARDRITALVCANMSGTEKRRLVVVGESPLPGPPSQRAPERTPVFYSVHPRARMTSALFRAELRQWDRELRLQSRKILLLVDPGPARPRADGLRNIRLAFLPAGRPGRPRPLGRGVVGSLRGHFRRLMTLRRVERAGRGGDPAATLGDALWAADKAWGGITEGTIREGFRQAGLAGADPGAAGDGGGGGDDDLPKPGWPRWTEEADGYADGFPDPDPDVFAVSRPPAEPPGDRAGGPGAEEKAEEAGGAPSPRDALRAFRLLRRFYRAWEAEAPIPPLGRRKVPVTFEDVAVYFSREEWAALDGRQKELYRDVMRGNYELVASLGCPAAKPDLICQIERDEELGVGEPQGRPVRRQPQRRSSGGGARVQREDRLGAGSDADAPASRVSVRTPGWATRRKPPTEQKLPGGNLAEKPPGGTLRGLPSRKKPPTCPECDKSFKSNTALTIHERSHTGERPFKCPDCGKGFPSKGDLKRHQKTHVGERAARPGREPPPKPLPARPHRGHPAPRKAHTCPRCEKTFRKGRDLTKHQRSHTAERPFACLQCGSRFRLKQILVSHQRIHGGERPFHCGDCGKTFGQKHHLLSHRRTHTGERPFSCVQCGHSFSQKHHLVSHRRIHTGERPFPCPDCGKRFKDKKTLIIHGRVHSGERPYSCAQCGKTCSQKQHLKSHLRTHQGPGAGAGEREGRAPAQHRLRPEKPHKCGKCEKSFRDERIMLAHRGTHAEETPPERWPGVRQKRPPALAPSAHLRQAEARGPSGRLVGSPAPS
The following text describes a protein:
Function:
Venom protein with unknown function. Does not induce paralysis when a high dose is administered by intrathoracic injection into the blowfly Lucilia caesar.
Subcellular Localization:
Secreted.
Sequence:
MKIIKLITIFTMMATLMXXVANGEPIPPNAVKSLQG
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MSCGNPLYLQWIQEWMEESTRRYPKSYQTWRKAYESMKNCPVTFTRPSEASVLKGIGPTICAKLEKKWTEYCKENDIPLPEDNSVEPSQAAATSNENENTAKSKTQRKKRPYVPSYRSGAYAILCALSKLHEHESAAKPQIIAIAQSHCESSFEVGSHSSNRYTAWSAMKTLLTKGLVYQSGHPPKYSLTEEGDEVCKRLGRVDDAFASSRWRQKDEDTHDSDEDALEKEDHEATDIDEVQVNAIAEVHRSNSSIDYEPRRINLNDCTILMLLDTREVRSRNDRDYIIDKLSTVHNVKCQVRALELGDVSWIARHNDTNEEFVLDYIVERKRLDDLVASIKDGRFHEQKFRLKRSTIRNVTYLLEESNYDEHFTDSIKTAITSTFADQHFFVKRVTSLDNSIQYLARMSRAIELHYRKTEQLLVVPDLAVEARSLEDLHERMQIHTLGQRHHLSYHSFASVMSKTSTMTVGDVFLRMLMTIRGVSPEKAMQIQQLYPTMISLVEAYERLKSHSEREALLSTQCKSFGRRSIGFALSQKIAKIFHPGTLNQYHEQT