lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in cell wall organization and biogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MTVIKTEPTTEVTLYSPPSKESLSKDDAHRKKQNNKPPSSINSRSGPNKHKLAAKAPEKKINNTDKQDLSAFLLNPSLIVKPSESKKKENIVAYNDTPGIKTEHTAFQPLTPISKKRALKEKAASEKCDSFDLSRDEKPYIQKKSKTLSSVTEINSSEYKLSLNGENTSSPAKEKSQEPIENPGSYQKTRNYLFEKPDPLDTCLQDYSSMLPSNVAEEDQEYFISVADSTLEEWTNKGQEIIDQQFQLYQEIIKKRIELSYKFKGIISVINDRADALEEQGQQLEGKIKKVKTLANEILNII
The following text describes a protein:
Function:
Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate, in vitro. Regulates DNA damage and repair by regulating HIF1A degradation via chaperone-mediated autophagy (CMA).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly located in the cytoplasm.
Sequence:
MACSEFSFHMPSLEELAEVLQKGLTDNFADVQVSVVDCPDLTKEPFTFPVRGICGQTRIAEVGGVPYLLPLVNKKKVYDLNEIAKVIKLPGAFILGAGAGPFQTLGFNSEFMPIVQTASEHNQPVNGSYFAHKNPADGACLLEKYSQKYHDFGCALLANLFASEGQPGKVIEVQAKRRTGELNFVSCMRQTLEEHYGDKPVGMGGTFIVQKGKVKAHIMPAEFSSCPLNSDEAVNKWLHFYEMKAPLVCLPVFVSKDPGLDLRLEHTHFFSHHGEGGHYHYDTTPDTVEYLGYFSPAQFLYRIDQPKETHAFGRD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTASHLGVAADLGPLVRRLWRQEGAPAGGGAEEEEEEEAQDQALEQEQDQEQAQAEAFRRRFRQFRYQEAADPRDALERLRELCSGWLRPQRRTKEQILESLVLEQLLTVLPEEIQTWVREQHPQSGEEAVTLVEDLHRKPWRPRHWVTVRVQGQEVLSEEMAPRGVDRESVRFQLKGADARLEGTSQRKKKGQSPRVEPSEPQYRGPQQPLLLQGTAPPSPPPPQLPALSEEASSRDRGVTPTLLTPRCQKSLPLKDPAFSFSKEDWEHRDPAQGTRNRDIKKENCGVRVSVGEFPVPKSNVISVRERGEDTWIPDLRGFQGQELLNCSRAGEERVQDERIPARRERKNGSCQEGRNFAGVNWGYEETLTFLNILRKTQSYEKLRTFPRNSQVYVSVAEQLRDYGFLRSPEQCRTKFKGLRASYRKVQNGHPSDSCAFYEEMDALLNSEAAVPTPGSLMAAAAPPLRQRGAETVGQGNRGWEQIKAEEEVELDDSDGNETGGEQLYQESRSPSPPALSPNRPGVHWSYEETKTLLTILIESQVFKTPRTSQRNSQVYGPVAERLQRCGFLRTPEQCRTKFKGLQASYRKVRRGRVTDTCVFYKEMDVLMRAQAAARPAEILEAGVAWPRKRGSLAETPEQGGRAYEGLAEVSMTEDFGAEEVEVKKLTQRPGNHSAPTLSPNHTGLEMGNEKNSKWKMPENLELFRLMSGRSERVGPRCHNQEKGPEGEYRAGTQCGVSAGQRLKEMAAQEKDVGKVKGRQRRNMEEKPYMNSNSVKSFTLNSHLIPSQPYLQPEAPHKCSECGKCFSGGARLMRHWRIHTGEKPYKCLDCGKCFSNSSNVVAHRRIHTGEKPYKCGECGKCFNQSSSLVVHQRTHTGEKPYKCEECGKRFNNSSYFCAHQRIHTGEKPYHCGECGKSFNNSSHFSAHHRTHTGEKPYECPECGKRFSKRSTLTKHGRVHMKEKVLKQPKSN
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts (By similarity).
Miscellaneous:
MISCELLANEOUS: Involved in mitochondrial-nuclear incompatibility, a major determinant in reproductive isolation between species, through hybrid incompatibility of Ccm1 and its interacting partner 15S rRNA between yeast species.
Subcellular Localization:
Mitochondrion.
Sequence:
MLNKCSGSLTLLAVRRFCGPCRRLHYHKDNPNNINIAKNLLNNNIQARCSTNEASWKLAQKELDLKIREYEQKLKDVKLNDINKKSPLNIPDEVWTKFISEVNSYDKEKENHLSTGNHELRRTTPLKIGPLLLTRIGLLKSKNTASNNYSVDHIVSNLANDNTLLNRQVSTEEWNSHLRHLLNIPKCFLGVDIVEIVNFFNYLPQTVISKSSLEIWKAVEESGMKVMPDLLVLLMESTNASGDFRKTVQLYHLYQKSNAPPNGLVYQSYAIALSSLGKHKDLVALYSEQKSVSITPSKDFLNACIKAFSRTKEFTKAWEVFNFMKFTATSISPSAETYGLMIQICSSQYNPEKALDLYNEMKLRPIDPLTPTTFVINNLIHALATDVRFQTVAFSLLQDLSHYGLRPNHSTLYELIRLIAYSGKLDYMKDILDNFWVRQKLLPSILKVEQIFHFIFRALISAEVQTSSVTPDYTHFKEEVRKIIDSSKEPLIPFLKRSTLTENDLFLNAIYTFEYAKRKFPEALNSRLVTDFLNIFLERGSVQLFKEIYQLEFREMSTMEGSSMKVAKITLTYIYAIKLALLFNDFEFGYAAWQEYWHCKIHKLLPKEDASYEQKVVLLTLSLLSKNKHTSLARSLLLSHLDKGWTWNKHSLGFMRKMCSVMNDQATVYLIDSITNEIGINQRFTRK
The following text describes a protein:
Function:
Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEPSTPSGPVDGWDRTSPPGPAGPEPEWPPGPPLGVENVVTLVVFAIIFALGALGNGLVIAVLARRRPGSARSPTNVFILNLSVADLAYLLFCVPFQATVYALPSWVLGSFLCKFTHYLFTVSMLVSIFTLSAMAVDRYVAIVHARRSPVLRVARNALRGVGLIWALALILAAPVAQNQRLVYSALGNLTFCWELWAEPGHKRLYVVATFVLGYLLPLLIICCCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRQAYRQVFRCQLGSPTPLREAKDNRSRQDTPPSTNCTHV
The following text describes a protein:
Function:
Possesses chaperone activity.
Subcellular Localization:
Peroxisome.
Sequence:
MADRGIFLYPFRRFQEWSRSTALIDWMESNNSHIFKINVPGYNKEDIKVQIEEGNVLSIRGEGIKEEKKENLVWHVAEREAFSGGGSEFLRRIELPENVKVDQVKAYVENGVLTVVVPKDTSSKSSKVRNVNITSKL
The following text describes a protein:
Function:
Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Enriched at the chromocenter.
Sequence:
MERARPEPPPPPPPPPRQPPRPTPPRPLRPAPPAQPVEAATFRAAAAERSQSPSAQATAAMAAVASSCGEAAAAGAQAAGTRRLLQVKPEQVLLLPPGGPGVPPAPDEGAAAAAAAAAAAASSAQARLLQLRPELLLLPPQSAADGGPCRPELHPMQPRTLLVKAEKQELGAGLDLSVGSRRTTEAGPRASRAAKLDGTGKALDGRRSDEKKAKLEAEEAPRDALKGGEGKSLLAIGEGVIKTEEPDRPRDDCRLGTEATSNGLVHSSKEAILAQPPSAFGPHQQDLRFPLTLHTVPPGARIQFQGPPPSELIRLSKVPLTPVPIKMQSLLEPSVKIETKDVPLTVLPSDAGIPDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGKRKRFPLSVSNVFSGTTQNIISTNPTTIYPYRSPTYSVVIPGLQNTITHPVGEAPPAIQLPTPAVQRPSPITLFQPSVSSTGPVAVPPPSLTPRPSLPPQRFSGPSQTDIHRLPSGSSRSVKRSTPGSLESTTRIPAGASTAHARFATSPIQPPKEYASVSTCPRSTPIPPATPIPHSHVYQPPPLGHPATLFGTPPRFSFHHPYFLPGPHYFPSSTCPYSRPPFGYGNFPSSMPECLGYYEDRYQKHEAIFSALNRDYPFRDYPDEHTHSEDSRSCESMDGPPYYSSHGHGGEEYLNAMPTLDIGALENVFTAPASAPSGVQQVNVTDSDEEEEEKVLRNL
The following text describes a protein:
Function:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MELSMKKFTVRRFFSVYLRKKSRSKSSSLSRLEEEGIVKEIDISNHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTIDWNKLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLVQEPSQQDVPKAPIHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWIVNREYLSQNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSSLAQRRGMKRLTSTRL
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
Sequence:
MQSVRLTSVSLKTKVFDFQGNLEKIKRVLKLEKKSDLILFPELCISGYGCEDAFYFPRIWKRSWNSLIQLLPHTENKIIVVGLPIFQNPYLFNCAAVLCNGVVAGIVPKSNLASTGVHYENRWFTRGEESQENFIAPDGSTIPFGSLIFETDHFSFGVEICEDSWVLQKPSIPLAEAGTDLILSPGASHFAFGKQRIRRQIFQESSRRESNVYLFSNLCGNESGRLIFEGGSMIVQNGKLLSESERLFFGDFSLCSNEIDFEASQADRAKNFRPSGNRFSKTKSTEENKIYLGIEFPKRAPKVNKSLLEISVSKEEESYLDFTKAVALGLFDYLMYSNTKGYTLSLSGGADSSACALLVTAMKKIAKLELGENFFKSKGIPEESILCTLYQSTSNNSDRTKFLAKSLAKEIQSIHGDLTIDSEIQSISEKISKLTGISLRWDEHNLTLQNIQARVRSPIIWMLANLNGHLLLSTGNRSEASVGYTTMDGDSSGSIAPLTGVSKEFILKWLRFVSEGKDPILPAYPSIKEIVNSPPSAELKPPEDKQEDEKDLMPYPLLQKIEELFIVRGAGYSEIIQLLSEDSEIQNLPPKFLEESVKKYISLFHKNQWKRERLPPSFHLDDYGLDPKSSFRFPILSEDIEL
The following text describes a protein:
Function:
Involved in chitin degradation. Catalyzes the cleavage of glycosidic linkages in chitooligosaccharides and in alpha- and beta-chitin. Its activity on chitooligosaccharides increases considerably with degrees of polymerization (the initial rate of hydrolysis for GlcNAc5 is about 130-fold higher than that for GlcNAc3). Its activity is greatly stimulated in the presence of the lytic chitin monooxygenase EfCBM33A, which attacks the crystalline structure of chitin and makes the polymer more accessible to the chitinase; combining the two enzymes leads to rapid and complete depolymerization of crystalline chitin, especially with beta-chitin as a substrate. Is likely involved in a chitin degradation pathway that allows E.faecalis V583 to grow on chitin as a carbon source.
Subcellular Localization:
Secreted.
Sequence:
MKLKKIIPAFPLLSTVAVGLWLTPTQASADAADTMVDISGKKVLVGYWHNWASKGRDGYKQGTSASLNLSEVNQAYNVVPVSFMKSDGTTRIPTFKPYNQTDTAFRQEVAQLNSQGRAVLLALGGADAHIQLVKGDEQAFANEIIRQVETYGFDGLDIDLEQLAITAGDNQTVIPATLKIVKDHYRAQGKNFIITMAPEFPYLKPGAAYETYITSLNGYYDYIAPQLYNQGGDGVWVDEIMTWVAQSNDALKYEFLYYMSDSLIHGTRGYLQIPNDKLVLGLPANRDAAGSGYVVEATPVAKTFDQLAKDGNPIRGLMTWSANWDVGQDVNGKSYNNEFATRYSNLVK
The following text describes a protein:
Function:
Predicted to be involved in rRNA processing.
Miscellaneous:
MISCELLANEOUS: Present with 8970 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGSEEDKKLTKKQLKAQQFRKSKEEKDQEKDVKKEQAPEGKRPNSAAGNDGEEPVKKKRKTRRGRGGKGKNGKKGNRFIVFVGSLPRDITAVELQNHFKNSSPDQIRLRADKGIAFLEFDADKDRTGIQRRMDIALLQHGTLLKEKKINVELTVGGGGNSQERLEKLKNKNIKLDEERKERLTKMINDGNQKKIAKTTATAAQTSGTDNKPVPAGIHPDRAKLLK
The following text describes a protein:
Function:
Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins.
Miscellaneous:
MISCELLANEOUS: PIPSL gene appeared in hominoids by L1-mediated retrotransposition in a hominoid ancestor of a readthrough, intergenically spliced transcript between the PIP5K1A and PSMD4 genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MASEVPYASGMPIKKIGHRSVDSSGGTTSSALKGAIQLGITHTVGSLSTKPESDVLMQDFHMVESIFFPSEGSNLTPAHHYNAFRFKTYAPVAFRYFWELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIVKTVRHKEAEFLQKLLPGYYINLNQNPRTLLPKFYGLYCVQTGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYRRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADVHNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALIHDGDTVSVHRPGFYAEWFQRFMCNTVFKKIPLKPSPSKKLRSGSSFSQRAGSSGNSCITYQPLVSGEHKAQVTTKAEVEPGVHLGCPDVLPQTPPLEEISEGSPTPDPSFSPLVEETLQMLTTSVDNSEYMGNGDFLPTRLQAQQDAVNTVCHSKTRSNPENNVGLITLDNDCEVLTTLTPDTGRILSKLHTVQPKGKITFCMGIHVAHLALKHRQGNNHKIRIIAFVGNPVEDNEKNLVKLAKCLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISFPILAGEGGAMMGLGASDFEFGVDPSADPELALVLRVFMEEQRQRQEEEARQAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGHTGLPDLSSMTEEEKIVCAMQMSLQGAEFGLAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAVGSLASQATKDSKKDKKEEDKK
The following text describes a protein:
Function:
Putative glycosyltransferase that could catalyze the transfer of galactose residues from UDP-alpha-D-galactose.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MQVTFCRLRTHQWCFILFNVILFHALLFGTDFVEEYFLHSLPYIDVKVLEIKNKARKLNIEPLRSNLSKYYVLSQSEICKGKNIFLLSLIFSSPGNGTRRDLIRKTWGNVTSVQGHPILTLFALGMPVSVTTQKEINKESCKNNDIIEGIFLDSSENQTLKIIAMIQWAVAFCPNALFILKVDEETFVNLPSLVDYLLNLKEHLEDIYVGRVLHQVTPNRDPQNRDFVPLSEYPEKYYPDYCSGEAFIMSQDVARMMYVVFKEVPMMVPADVFVGICAKFIGLIPIHSSRFSGKRHIRYNRCCYKFIFTSSEIADPEMPLAWKEINDGKECTLFETSYELISCKLLTYLDSFKRFHMGTIKNNLMYFAD
The following text describes a protein:
Function:
May regulate cilium motility through its role in the assembly of the axonemal RS2 radial spoke.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MNQLEEIVKYVIYKCRENNHPVTETLAAFVTQTIYNPKTDRFYLEDKLTASQVDELKATVLQKLSQIDKPNMKTIQMQISYDSAYIESEIQRQERIKNQSIETGKLTDEVVSLEIKNAKDFEGLTVLFKKIFNFLLYKNKELMYDGTNKTGNQDSENQATQFNIEKEVAAGLESVIPRAALGPFVSLNPSEKVTQLVELSNLVIGIRLFNKWIQKGGIGLVPFQDLLEYEGRDLIERIRQEAFEVIENCDNYTIFFQNVGPGKIKISDEQFKQYKDELTFLRQYLSYILSIQEDVDISENSVDSNQTRYLKEIKDLETLLKQKSSAPKEQVYPKFATLAQAYIQLLEEKKLCLTRVKLFELLQEMRKGFKLTLPRNLILTAKNISQDPSNEEQVEIEYSEDCGIERLLPKNTPDFMQTPLDYLGFCLWSIVKRDGLLLPGKPALGVFRYKDKNCVFSDEKSINEFLSDPQQFIQGVINQCRKNPELIHLLRMDDSFKNVNLNIYVSGQEGGHQLSNKLMVDKGIETPLHFVEKRLDPNYCWNEWELRKKALQMANIRKRQTKACQTILSNFKVDSEAQTYLPKDNETNTGKTEWDIRKFAIEQAKKKGIIAGTDRAPYPIHPRNYITGLRDKDTN
The following text describes a protein:
Function:
Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Positively controls degradation of transcription factor GCN4 under favorable growth conditions. The PCL5-PHO85 cyclin-CDK holoenzyme phosphorylates GCN4, which is required for its degradation by the E3 ubiquitin ligase complex SCF(Cdc4). Amino acid starvation reduces PCL5-PHO85-associated GCN4 kinase activity and leads to stabilization of GCN4.
Sequence:
MDGNHRFTPDSKEFNTVVKSKESSTGRNPYQTPPLEHNGTHHQTNYSRKKTNLAIIISNFLSEISRPLSNGKINNSTHNILKFLNEVLKRSKCSKENAVLATFYFQKIHQSRGVRDESSLPEFSHCSRRIFLCCLILSHKFLNDNTYSMKNWQIISGLHAKDLSLMERWCLGKLNYELAIPYDEFLLWETNTLMKAKLRVGTPANAPVKRPRESDNDYDANSWKQIKSC
The following text describes a protein:
Function:
Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
Miscellaneous:
MISCELLANEOUS: In ESX-1 cluster, the FtsK/SpoIIIE-like protein is split in two genes.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAGGTRQLSPYMLMMPLMMIVMMVGGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATRIGIGDQPAVDRLLKPAVGGELAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTAMICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLIFTRQEGLSDLAARGPHAPDSLPGGPYVVVVDLTGGKAGFPPDGRAGVTVITLGNHRGSAYRIRVHEDGTADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITGTILDKTSRVQKKVATDWHQLVGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGTTGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQSILRQAGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGGPGQQTTRQAARIHRFTAAPVLEEAPTP
The following text describes a protein:
Function:
Inhibits ecdysteroid biosynthesis in the prothoracic gland of fifth instar larvae, with maximum inhibition during the spinning stage. When administered to day 8 fifth instar larvae it produces a significant delay in the commencement spinning behavior.
Subcellular Localization:
Secreted.
Sequence:
MRWCLFALWVFGVATVVTAAEEPHHDAAPQTDNEVDLTEDDKRAWSSLHSGWAKRAWQDMSSAWGKRAWQDLNSAWGKRGWQDLNSAWGKRAWQDLNSAWGKRGWQDLNSAWGKRDDDEAMEKKSWQDLNSVWGKRAWQDLNSAWGKRAWQDLNSAWGKRGWNDISSVWGKRAWQDLNSAWGKRAWQDMSSAWGKRAPEKWAAFHGSWGKRSSIEPDYEEIDAVEQLVPYQQAPNEEHIDAPEKKAWSALHGTWGKRPVKPMFNNEHSATTNEA
The following text describes a protein:
Function:
MFS efflux transporter; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu. Reductive releasing of the lipotripeptide by the TE domain of inpA produces (2S)-fellutamide B. InpF might be involved in the release and transfer of the lipodipeptide from inpB to inpA. The inp cluster-encoded proteasome subunit inpE confers resistance to internally produced fellutamides. The MFS efflux transporter inpD may contribute to fellutamide resistance as well.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEKTQTPSLTPDELSARSSTPFEEREEEEEVHYVGHLKFSFIFVGLCLSVFQVALSLQDIGWYGSAYLFTDCAFQLVFGRLYSMLPVKIVYLGALLLFEIGSIICATAPNSIALILGRTIAGIGAGGILSGALTILSQSVPRAKVAVFNGILGAVNGIAFICGPLLAGGIINGTTWRWIFYINPIISAPTFFITVFLLKLDPPKTNVKTWRGRIAMLDLPAFTLFLGSILCLILALLWGGKEYSWKNARIIVLFILFGVIMLAFMLVQKRKGDDALVPMRILCQRSIAFGMFFSFCTSGTGFILEYYLPIWLQVIKDLSVISSAVKLLPIIAAAVVFTTLCGILTPVIGHYVPFMIIATMLLSVGMGLLSTLEYTSPIRHVLGFQVPAGVGLGCALQQTLVAAQTILPMNDIPIGVSLIVLAQTLGGTIALSAADTIYTGTLSSSISSRFPQINRETVLTTGNREIRNLVPAESLSVIMDLCNKAIVKTWYLSIGLAAASIIGVLGMEWRRVTPPKK
The following text describes a protein:
Function:
Regulates myosin phosphatase activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, stress fiber.
Sequence:
MSGPGADGAAAAAAARERRREQLRQWARAGGAGEPGAPEPPPRVRTVRFERAAEFLAACAGGDLDEARLMLRREPEGPAAARPAPAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYTDIAQYLLSHGADIAAVNSDGDLPLDLAEADAMESLLRAEVARRGVDVGAAKRAEEELLLQDTRRWLDGGAMPDTRHPRTGASALHVAAAKGYIEVMRLLLQAGYDPNVRDRDGWTPLHAAAHWGVEEACRLLVEHAGDMDTLNNVGQRPCDLADEDVLTLLEELQKKQEDLRNQKEACQGRVTEPQPLYSSKHRRSSVCRMSSKEKISVQDLSKERKPPPGGGPGETPGVGVGVGGVGAPGALNGVSSPLLGPPSPLSSTPGGPWRSGLRKTGSSGALGPSGRQRQEPPELGLQRSASSSRLEGGEKNQEPRLARVPPTPSRRMVSLPESRLPTADTSDPPAPSIAPSDSRDRRRSYQTPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKTLGRSVEPEKGEPPPADSPVGGGSAPTPRCGPHLWPSCPHSPPPPPPLPPSLPIPPKPRFSPPVGWTGGWGHAPTPTHTISTPAPSRCPLPRPQLYEGLQAENATLRETLQETQLRLTQLKVELERATQRQERHAERPALLELERFERRALERKAVELEEELKALSDLRADNQRLKDENAALIRVISKLSK
The following text describes a protein:
Function:
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDTNWLYVLLQKSTADPLERLKLGNVILNEISQRKVSPHPKLVNDFLDVMSGWLTGSNFKVTIIGLEILDAALRTSPEVLASYYFDRLSVLIERMGDAKVQVREMAINLCRQLAYLENSSPVMLLDRLCVHGTGFEHKQWLVKVGSLNILRDFLSDSFALVIPQAINLIPQLCRLTNDPNSEVRDASTNCLVDLMVFGGKSIIAKIANTRILNEQKMATLLQRYESTIATRGDLPPKHSIPIETSSIPRNNLLRRSLRSPAKIIHPSASTTSFTSSARLSTPPRTNAPSLSPSPSTPSPLSLPAANGRSRDLARSSLRAPAGMSLSRYRSSSCAPAAQCAITLDDFKKAFNAVPKISIYSNSDVREKLETANSVLRNANEDWSKRANQLKLIRSVILNSDDSIDQRLLLSLINELADALEFSIRDLRSQIVREAAITCSFLFEHFGMDVRNVAECVLPAALAQVAVSTKIMASSAATLTVFIVQKIQTRQIFQTLFDLSTSKSKEQRRQLANLLETLISSWDLKVKQPILKSISQLVQNAICDADGETRVAGRKAFAKLEQLHGAAADQIFRELDPAKQKMLRDGVSSSSSSLNSDRDNNNQKQPQQPQQNISQKFLSQRSASALDNKSQVLSIAKPQQSNPSRPTAMPVNNRLPKSSTSSSFSAVRSSGYGQSRAKTPSDGFGGTNFNNNNNNNNKSSSSSPSTSTHQTPIQRVASNLGSSSFVASLTQEQASSLQNAMDLAKDEMSKNNEDDEFLLAEVRKTPPKETSPPASLYARGYGNGSNGSNNSSNNSIQSVEHILKACTSSSINEKRDAIISLSQKLLDRNLDSLECKNIGDTLSRLLAEGNTTLIISILETISIFVKCHYKKLDGWLKLALGKLFAKMGADSLPNVKSALSSTQKMFLTTFDPSTQLKEVCDFMCDPVHLLAPKSRLALLEYICLLFEEIWPEDPRCLERQTQLDTPYTRAAVRKMFAWMFDPRIGAILMPACERLVCALFALNAADFTMIFGDLPPECRDWAYRILQLNGQQQSAQRQQIMEKEAITMTNNNYKPCPPEVEKFEKVSVKASFSTYEATRVPEPQDYRKPTVHLAKNHVEQAAYIRNQMDLMRDFQKPDRVNEAMANLHGMMCEGSFTLWNQFFDELLDEIYQILSTLSQSIRKKLAMRILQKMCTAQATKLFDSTEIAISKVLQCACTSEDNTMSVAAEDCLRILATHLPLPRIVQISRRILSQDDDDQRGVLILKMLTRMFQDIDVDELHMIVDDVAPCFVSAYDSTSSSVRKCAVFGLVALVQRVGMPRLETHLRKLNATKLNLIDLYVGRAKSSESGTSSN
The following text describes a protein:
Function:
Stabilizes the atg5-atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The atg5-atg12/atg16 complex is required for efficient promotion of atg8-conjugation to phosphatidylethanolamine and atg8 localization to the preautophagosomal structure (PAS). Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Required for meiotic chromosome segregation.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MELIKKIQDRDAAEKAYYDVIEPYSELLEFSFHKEFVSEEKVTQRTASSDSLNTIASENNDENVINLEEFRQLKRNCDLYQRNLQKLQLLFKQQSQKNTLLEKQLSLQTELNQEKDKRVKILQDELWALQLEVAALERKSPNA
The following text describes a protein:
Function:
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP, dCMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
Domain:
The N-terminal domain (residues 1-84), characteristic of archaeal AMPpases, is essential for enzymatic activity, participating in multimerization as well as domain closure of the active site upon substrate binding. Harbors two dimer interfaces within a single molecule: one by the central domain and the other by the C-terminal domain; these two interactions can continuously occur in a repetitive manner, leading to multimerization.
Sequence:
MKAKIRILDMFSGRYTVLINEEDAKEAKLHPDDLVKIEAGKKAVYGSVALSNLVGKGEVGISRDVLDLHNFSEGETVSVIPAGTPESVRYIKKKMHGEKLRKVEIEAIVRDIVDRKLRDIEISSFVTALEINGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNILVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVFADVSFSLDEIKRIVEKVGACLVWGGALNLAPADDITIKAERALSIDPTGLMLASIMSKKYAMGSQYVLIDIPTGKGVKVETVEEARSLARDFIELGKRLGQYVEVAITYGGQPIGHTVGPALEAREALSALMTGKGPGSLIEKATGLAGILLEMGGVAPAGTGKKMAKEILESGKAWEKMKEIIEAQGGDPNIKPEEIPIGDKTYTFTAATSGYVTAIDNRAITAIARAAGAPEDKGAGIELYVKVGEKVKEGDPLFTIHAEHEARLDQAIVLARRTEPIRIEGMVLQRIGNI
The following text describes a protein:
Function:
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLLQLLVSVHLITIIIFFVFIPQEAGASLTKPGCPEKCGNVTIPYPFGMGKGCYLHRDFEITCNMSSNPPLPLLQEVQLLQISEDNLRINDIAYRSCFNNQSGKTDSSYILYNRTHHFSYSYTHNTFVAIGCDIFAYITGYNSTAYATGCASLCNTDNDIAAGFSSSACSGIGCCRTYLQTDIAHFYLRIRSINMITPTWSSEPCGLAFIAERNFSTLEHFNLSSKFDKKLYFVPAVLDWSVGEVSCHEAIRRKNYACGQNTYCNNSIQGRGYNCHCLNGYQGNPYLANGCQGTVLLLFNILYLLFCHSHKLMNFLLIFFFSFVLSKDINECNDPNQNVCHKIALCSNIPGSYSCNCPSGYHGDGRKHGTGCIRGKRKHLLLLVFSLGVGIIVVPLILISTGLRLYRGVEEREKKKIKQEFFKKNGGLLLQQQISSSKESVEKTKLYSVEELERATDGFNSGRVIGKGGLGTVYKGMLSNGSIVAIKKSNTVDEKELDQFVNEVFILSQINHRHIVRLLGCCLETEVPLLIYEYVSNGTLFHHLHDEGHASTLSWKNRLRIGSEIAGALAYLHSYASIAICHRDIKSSNILLDENLRAVVSDFGLSRSIPLDKTHLTALVQGTFGYLDPDYFHSGQFTDKSDVYAFGVVLAELLTGEQAISSDRSEQGLANHFRSAMKQNRLFEILDNQVVNEGQKEEIFAIAKLAKRCLKLNGKKRPTMKQVDIDLQQLGRFQGLSLQKTWIQEPSLQQQTCEDYCTLHETRVGAADRGHGVSWDGDQLSKE
The following text describes a protein:
Function:
Required for activity of the tor receptor, could be a ligand of tor. Involved in specifying terminal body pattern.
Subcellular Localization:
Secreted.
Sequence:
MKSQSELAIVLTWLAVLGTAQDDADYCAELSTQSLAKILGQAFNPRYMSIDPPGEPEEKSYHLGYKRSSYELPFYADSDAISVSHFPAWETNHFALVEKKKEAPRSKSLRTRSAFMDRVGHPRIDGFKQRPWECSSKINWIDLGLNYFPRYIRSIECIARKCWYDHFNCKPKSFTIKVLRRKTGSCIRINDKLILITAEKFENDYTQLWIWEEIAVNFCCECVMLY
The following text describes a protein:
Function:
May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Sequence:
MVAKILDSKLRGSFFHYGRVLANCPAPFIVLPLVLSAMLGYFGGSRLILGDDLEYLFTPEDGQAKRDGTAMRDAGFQPTDLTASWSAGRVIVKVKDDWENILKSDAVDEILRLNDAIRNATNTDGETFTDLCFRTQLGCLESNILGLMSNFRLLNTSQDMNITYPHYNPFGVGGLWPDLYLGDELGGVDTAGDSRTVVAARAMQLIYHVNATGQRRISMMTAFHRAVADFRSDRVLAFFTSGDSLNDEILTLPERVMPYLAVSGGLLIVFAVGSCTMADCVLTKPWVALVGVMSAGLAVVSSVGLVLLCGQTFPTHVAMVPFLLLGIGVDDMFIMIASWRKTDSRLAVPERTGHALADAATAITITSLTDCVAFAVGTITVFPAVRIFCIYAAVGVAFDYVYQITFFAAILSLAGRREKAGRHWLTCLKVPTNEEAGQMSSIKKLCCSGGNPAQDDVSDQHSDEDRRLPFMNKLLCNYLAPFVVNPLGKLLILLVFFGYLGVAIWGCFHVRVGLEFENLVADDSFVKDFYRAEHRYFKEYGPKVDIIDTGPCEYWKDEVQEAVRNKMSSFDKSPFFKNSSTTAQVWLEDYLLFLKNTGNGSAATDETLFLYLLNTQFLPTVGRHHKMSIIFNSNFTAIEASRFVVITRNVKTKEQEKDMMLEARRIAEHGPLKMTAYTIDFVFSDQIDEILPSTLQTILIAAAAMFVVSLVFIPNCISTMLVTFAVVSIDAGLVGYMALWGVQLDIIATISVIVCIGFSVDFSAHITYAYVSSEAETTGEKMREALQTVGMPIIQSSMSTILGLLVLAFFPAYLFRSFFKTMFLVMVFGSSHGLLVLPVLLTAPCPKCCNARHHRKGAIANQKAQETAKENQTRETASSPKRSLHSSDGYIPMKTMCSSEMSREDTIERCLQDAEDTLLTVILEGKAAGLDNPVLRVTPLRFNEETRTTTL