lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MRVPLLMENGSYEIKFGPANLETPYRARNCLTRDRYGRYHLSNQMDQIRDISHCHIRRPSELGQLISWELEEQIWDYCLFNPDEFGWELKDSKDVDLIASETCMTIPEISKNMDQVVFEEYEFGSMMKCPVAQFVPFDRARDYDIVGGAGEVVEAKSGYNNFQLVVDSGFNCTWVMPVIKGVPYYKATKKLDIGGRFLNGLLKETISFRHYNVMDETILINNIKEQCCFMPPVSYFDSFQRKEETRVEYILPDFQTSLIGYVRQPKQAIPKTSQILRLEDELFTVPETFFHPEISNILKPGLVETILECVSMVPEVLRPLLVSNIVAVGGNFNIANFATRLATELQRQCPTDWKVRVHQPKLDAALQGWKSMRQFSQTDSYKNSRVTRSEYLEHGADWCTKHRFGYEQWI
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MDPQARPQSSLLTAAPELSPLEQEVLDEYERLSENMKKLAVLLDELASAPATEILDGLRELERKTSLVFTLLKASVYSIVLQQEIDWGGGAGDGH
The following text describes a protein:
Function:
Involved in the first step of essential amino acids lysine, threonine, methionine and isoleucine synthesis via the aspartate-family pathway.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAIALRFAATPRRLAASIPESYPGHGVGGVARAGALWGTRRGWRLAMVVVPDSTRCRAKRGGDGDGVLGVAADGGDAAVGGGDQLSVVMKFGGSSMSSAARMEEVAGLITAFPEERPVVVLSAMGKTTNLLLLAGEKAVGCGVIYVSEIEEWNMIKDLHIKTVDELGLPRSVIHSMLDELEQLLKGIAMMKELTLRTTDYLVSFGECMSTRIFAAYLNKIGIKARQCDAFDIGFITTDDFGNAEILEATYPAVAKRLHGDWVRDPAIPIVTGFLGKGWKSGAVTTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCDPNIYPNAKTVPYLTFEEASELAYFGAQVLHPQSMRPAREGDIPVRVKNSYNPKAPGTLITKRREMDKVVLTSLVLKSNVTMLDIVSTRMLGQFGFLAKVFSIFEDLGISVDCVATSEVSISVSLDPSKIWSRELIQQELDHVVEELEKIAVVHLLQQRAIISLIGNVRRSSLILEKAFHVLRKSGVNVQMISQGASKVNMSLIVHDSEAKQCMKALHQAFFEGDHPLVVEIEEEDVEILQLRADHPV
The following text describes a protein:
Function:
Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs, strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner.
Subcellular Localization:
Secreted.
Sequence:
MRLPFWFLLAVVLSMELAVTQGLQCHLCKGFGGCSRPSSCPWSSTHCVIIATRSPISFTDLPLVTKMCYSGCPDVSSLGLGPHVSIACCQSNLCNRD
The following text describes a protein:
Function:
Involved in apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Plays no role in amphid axon outgrowth (By similarity).
Subcellular Localization:
Cytoplasm. Note=Punctate localization.
Sequence:
MPSTSLPYTQMAFHMPLKELQPVDTSLPEHIIKGAVVIDKELTTWNRRAVIPSTALHTVFITINRLEQKQADVVKMAAREMNLPEDNTYGLMADAPKRFITNENIDQLGSGFILTLCASPDNYVKRITEILEDGKNIAQMENAVKTLDEFSLDPALIEAFYRCSSLELLFDLVRDDRVSMSYTLLSTCLRALSSILELAVGDVTWKSVPRDVVVSIAALVTGKAKREEVNTLLAALAMIEQLVIGDDTTRDWVLEEVPIETLIRHVEKSDERIALAALSLMNSMIRHCSDKDKRLELIESLEVVPFRNAVHSSLLRDGSARDPKALEQLVEVQRSLISAYDTSPASDSEIQKVLDIDSANENSEEDVEIWRTKLAEHRCGRLATVAMVLFGEKSPQDLRMLISENTMRIEGGKWQLIPMWMRCCDITAELFGLLPGRDELDRLISIIFSTDSPFPAVFSCIVHLFHRTWREMQAKGGEMDKVASFVLEQLRHVLKRKEIHDVEEMSADLETFSYKAMQEVRREEQLEKENDQLHSEAVISLKAKLRPKIEELVRINHLNYLKKGDVFRKPMKSKSLAKAAYWFWKLDASEKMLTITACDGERFVDDGHRDDIRQVWLKDVADVTNNDEIDRKASSSRFASSPSTNMLRGVRVQLKPTNDLKEGEVLMALTPDETQAGIWQESLAYLVGNTEMRSKTNAIVERMLKMELRVRLLNVKLADPENEPDVPPIPDDLISFISSF
The following text describes a protein:
Function:
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
Subcellular Localization:
Nucleus. Nucleus, Cajal body.
Domain:
The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.
Sequence:
MAASETVRLRLQFDYPPPATPHCTAFWLLVDLNRCRVVTDLISLIRQRFGFSSGAFLGLYLEGGLLPPAESARLVRDNDCLRVKLEERGVAENSVVISNGDINLSLRKAKKRAFQLEEGEETEPDCKYSKKHWKSRENNNNNEKVLDLEPKAVTDQTVSKKNKRKNKATCGTVGDDNEEAKRKSPKKKEKCEYKKKAKNPKSPKVQAVKDWANQRCSSPKGSARNSLVKAKRKGSVSVCSKESPSSSSESESCDESISDGPSKVTLEARNSSEKLPTELSKEEPSTKNTTADKLAIKLGFSLTPSKGKTSGTTSSSSDSSAESDDQCLMSSSTPECAAGFLKTVGLFAGRGRPGPGLSSQTAGAAGWRRSGSNGGGQAPGASPSVSLPASLGRGWGREENLFSWKGAKGRGMRGRGRGRGHPVSCVVNRSTDNQRQQQLNDVVKNSSTIIQNPVETPKKDYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQQVDIEILSSLPALREPGKFDLVYHNENGAEVVEYAVTQESKITVFWKELIDPRLIIESPSNTSSTEPA
The following text describes a protein:
Function:
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sortingg.
Subcellular Localization:
Early endosome.
Sequence:
MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSAVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLEDVTVEVSPLNVTAVTNGSHSETTSEQTQQNSTQDSGAQESEAPSENVLTVAKDPRYARYLKMVQVGVPVMAIRDKMISEGLDPELLEKPDAPVPNGESERAVEESSDSDSSFSD
The following text describes a protein:
Function:
May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTLLQLGVCAGSIYTTFLIWGLLQERLTKTPYTAPATLLHPNPQPDYFRSPLFLNTVQALFSSVVACMYLLVRNRGSNKRVTQILGLHTLTPDGIAEKTQNGRASATNGKAAPTRSRWISPLLSRYILIAALQSTASQLGFLSLRYISYPTLTLAKSCKLVPVLVMNVVLYRRKFASYKYAVVGLVTLGIWLFMAFAPSKPGKKAKAPESSSLIGLVLCLLNLVLDGATNSTQDQVFSMFGRQTVSAGQMMLVMNAISAFLMALTLTLPIPLLSTPGQPTQLSTAIAFTQKHPEVWRDIIAYALAGAVGQVSIFETLERFGSLTLVSITVTRKLFTMLLSVVVYKHELSKLQWLGVAVVFAGIGIEAREKRREGLANKVIHDEKRALAKDA
The following text describes a protein:
Function:
RNA chaperone that plays a key role in Cajal body formation. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs). Probably acts by mediating localization of scaRNAs to Cajal bodies.
Subcellular Localization:
Nucleus, Cajal body.
Sequence:
MIENSFKMEMHFKNRWQAASLFLRYPRTVTLCLSGKSGDMDESVNLSTSMGDVEASMLNHNVSFSSTMVTSNGDLSLPKLSVTLSAEEILKLRSGRPKNAVESPHAGVPMETSLAAEEEANGDEEEESVRVVDIEDTLELTSNGNEAKPEDQELAIAPVLQYFQGALVELGRRCWTSSTEAQHYTKGCYWSPDGTCLLVPVHLDGMHVIEMPSDLYSADTVQPARSLTKLQSEVHVPEGGTVYDCVWYPHMNSLQPETCLWLATRQHEPIHMWDAFDGSLRCSYSGYDAVDEVMAAISLAFSHDGEQIYAGYKRCIKIFDTSRPGRFCDDYPVKFAISCIAQTTAHPHTLTCGNWHGYIQHFDLRCSHKQGPLFTLGGHKGGITQLRYGEFGNGEWHLFSGARKCDKILQWDMRNYKQPLVELQRHVDTNQRIQFDLASDSNWLASGDTRGFVNVWDLKKYGDPSVLPLHSDCCNGVALNPAMPILATSSGQFHFTDQSAQGDNVTLNGTETTELPAPADVNQNQKEVLYENAVVMWWCGQTG
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MLKSNESKGYSRFSDVAVRTGSHGRAGEQSLHDAAAAIVQEPQNNLPLSSGNSDPGFSPVLPFINQQPGERPQHVEWMPMPAATIGNCSPGLSYLQPLHQWLVHYQVELFEFSRNFGVAHKFSVKNPSGQAVYMAGVVEDFVARCNSPSHLHEGRIYDVIEAEIIHFSWSDQCKCCCCCRMPGYLNEIKVESPPGKHLATIKQTASMACPCFEIMDNAGYTQLMIQGNNDIRNGLKDPRDFIFEIQLANKDQSIVSVDLDINLKAALLSLVLFTAILIFEDKKSLASK
The following text describes a protein:
Function:
May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.
Sequence:
MATVQDSGRVPVETWISVCPGGLWEVRRKRLGERSRGDTTPMMGSLCKVKVRRKTVTEENTLPTSSPEQESTAVVNCSEQTTSYPRSQESVLQVPLDEWLVLRMGEGQCDITEGCLEGIRAGEMCEFTVSAWNAACSDVDGTQTKNTTSQASSQTDCFTLELHSLTPGQESWQMTAEEKWAWVLSHKQRGGLRFGKGDIWGAADCYCRAVKLAITLQVQTRGKLVDETLKEDEENEDEDEDEDEGAESPNDSTIPNEEYKTVKAELHCNLSLCQLKLGQLGKSKDSSIKATELNPKSTKAWYRHGQACLQLGELEESRMAFGKILELQPDSASARTALKQVNSKLKDLDSKLGQRLSKMFN
The following text describes a protein:
Function:
RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus. Note=Excluded from the nucleolus.
Domain:
The RRM domain mediates RNA binding; the RNA must have four nucleotides for efficient binding. Mediates the interaction of NEXT complex with promoter upstream transcripts (PROMPTs) and potentially aberrant forms of other non coding RNAs, such as snRNAs. The RRM domain exhibits specificity for polyuridine sequences.
Sequence:
MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKLKQFAFVNFKHEVSVPYAMNLLNGIKLFGRPIKIQFRSGSSHASQDASVSYPQHHVGNLSPTSTSPNSYERTVGNVSPTAQMVQRSFSSPEDYQRQAVMNSVFRQMSYAGKFGSPHADQLGFSPSAQPHGHTFNQSSSSQWRQDALSSQRKRQNSHPYLADRHYSREQRYSDHGSDYHYRGSREDFYYDDRNHDGWSHDYDNRRDSSRGGKWPSSRH
The following text describes a protein:
Function:
Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.
Sequence:
MKHYVAVDIGASSGRLILGKLVNEKLQLEEIHRFKNGFTYRDGHERWEIDQLMQEIFIGLEKVKQLGISECVLGIDTWGVDYVLIGASGEKLADPISYRDKRTLNAVQNLTSEYPREYIYKKTGIQFMELNTLYQLYVEERDLLERAEKILLIPDYIGYVLTGVKVAETTNSSTTQMLNLREQLFDKDLLSHLNIDVEKFAPLTDAGTYLGEVKEDWLKMYDIPNCDVVTVATHDTASAVVGTPAEGENWAFLSSGTWSLIGMELSAPINNEVAFKENYTNEWGAYGTYRFLKNIMGLWIVQEIARMDDYKHSFAEMAEEAGNYPYFKQIINVNDARFNNPENMVDEIRLYCRETGQTVPETIGELTNCVYGSLALYYALELEKMTEITGKKIEKLYIVGGGSNVAMLNQLTAKLAGIEVFAGPSEATAIGNLVVQMINQGEIESMRAGRKIIRNSFEIGEFSCGDVRFEEIKERFTKVLEFN
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
Miscellaneous:
MISCELLANEOUS: Present with 5730 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=Enriched at crista junctions.
Sequence:
MMLRTTASRKIVLRRGLASINTGTTVASKKASHKFRNTLWTIALSATAFYAGGIIYSQKNDKFGDFFSNNVPFAEDLLETYEHYHDRPTLFLEDSWDGLKAKSNDLLSGLTGSSQTRRSNRENIEVKKILSLEPLNIETENSDPQLKEIIGSLNDLINSLNDSNLSIPESEFNSIKKSNQNMLTNLSQLNETLKEALSNYMIQRTSEVITELNTQYENSKREFEKNLQKNLLQEVDEFKENLTKQKDKELEEKLKANEELLQAKHANEVGLLSITQVKEFNKIIKDKIEKERNGRLAHLEEINSEVNDLSKSIDRSSKILSKNEALVQLTFQVDEIKSRINNNNLPDVNIDKELSRLKLLSNLLSTFNKKSCCDDGDCCSCKKGNKNEGKEGKISCKCKPKTNPPSLLSVALDELESTCSGKKILSNEQIYNRWNLLADDFKTASLLPPNSGILGQLTAKVFSLFLFTKTGNPSNATDFDSVYARVGDNLRVSNLNDAVEEVVSLKGWPHKVCESWIEDARRKLEVQRLVEILDCEIRTL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNKRINEVSGRPIGEYLSRDISDFQRVSRTLFECFSSLATGATLNSQQLQQIQLPIDQISNNATPNMVLQLMNHLIDVDKIYQNTLKKLEKHQKIQKEITEIQKEIEEKDKLISTLALNLKDIESFLENELSQDNVNINNGNASDGIVNEVLIDLKQPDDAASMDNIVNREVSPEDLISYAHKISGTTSAPFGYQPNAPLASLFKPPAPQDEMMRSSVLFTKPPPHVLKYYGLAEIDVTTPTMAANISSPFSIGGNVGDVTTPTSKEQEDQQQQQQQQQPQQQLSQSQQSQQQTESELQPIQSILQPPQQLNIDLDLNPDLDSSGDDDDEDDDDEESEEVEWD
The following text describes a protein:
Function:
Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Recycling endosome. Membrane. Note=Associates with membranes in an EIPR1-dependent manner.
Sequence:
MQKIKSLMTRQGLKSPPESLNDLGAFESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSADPFDIVKYELEKLPPVLNLQELEEYRDKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNSRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDVNHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDSEETAAASEGSNVMSTEETNFDRGYVKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIVSRLMQVGEEFCGSKSEVLQESIRKQSINYFKNHHRIRLDELRMFLENETWELCPVKSNFSILQLHEFKFLEQSRSPSVSPSKQPSATSSKPVTLFEQYCSGGNPFEIQADHKDEETEDVLASNGYESDEQEKSAYQDYDSDSDVPEELKRDYVDEQTGDVPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVGKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNRIQESLIDLEGSADPTATLTAAEERKEKVPSPHLNQLVILTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKAIDYEQMLLLMTNVKWDVKEIMSQHNVYVDALLKEFEQFNKRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVEIYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKARQKLLAAIDDIDRPKR
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MIQAVTSCFQFKRCTTHLLEFIAADKPMVGDALADPSDEKLAHFVRTTAALKIEYRCAQGPSPRVFELALAQLRALNRIAEWESGWVVYPLYTCARQLVQMAAALDARTERAAEAAQCGDLATEDHLTQCGRAVHMSLNLCLKDRDPAASNKRHGAYYFALLLFRTYARLGAHSLVTNMVKVLESRAQDLPPVERAFGERRALTVTYCYYLGRYHACRRADYEKGFRWLNTALLTCHRDHTRHHQLILTYLVPVAFLARRWYPKHHVIAAWPPPQDPAAIHYAALVAALRSGDLGLYDRELVRMQLPLLRRGLYLPLSHLRPYILLRLVKAVWRLSGGSSQLPIRIIAAALAYSTSATPDAGGERLLDHTECLLANLIARGYVKGYLSHGNRVLVVSRTEPFPRLVRSETAA
The following text describes a protein:
Function:
Diphosphatase (pyrophosphatase) with specificity for coenzyme A and CoA derivatives. Catalyzes the hydrolysis of the diphosphate linkage in CoA to give 3',5'-ADP and 4'-phosphopantetheine. Prefers oxidized CoA disulfide (CoASSCoA) over CoA as a substrate. May be required to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids. Can also hydrolyze 8-oxo-dGTP and 2-OH-dATP in vitro; therefore it may function as a sanitizing enzyme for oxidized nucleotides and may contribute to prevention of spontaneous mutagenesis due to the misincorporation of these oxidized nucleotides during DNA synthesis. Shows moderate activity in vitro with several short chain acyl-CoA esters and very low activity on 3'-dephospho-CoA while is not active with (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di- or monophosphates, diadenosine polyphosphates, nucleoside 5'-diphosphosugars, cytidine 5'-diphosphoalcohols, NAD(+), NADH, or FAD.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome.
Sequence:
MILSQRRMLSSKQLIENLIRYKFHKTPYTRSSIWPFKRNSAVIILLFIGMKGELRVLLTKRSRTLRSFSGDVSFPGGKADYFQETFESVARREAEEEIGLPHDPEVLHKEFGMKLDNLVMDMPCYLSRTFLSVKPMVCFLYKDKLEKHEDKYKVPLDIRKFFGKLNPGETSSLFSVPLNDLVIHLLPEADEDVKSYQAEYFERKEYKLNWGGIKWLIMHYHFHVANNNEMPWLQTIEDLSSSDEDGVDGGIFRFRDLWGLTCKILFDVSCIANGLMDEKLKGELGHEDLIVGLHDYGNQMQPNGRSEWEIGMINGDRNLKYSDVIPEYYMKHLLECRSLW
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in the spatial and temporal control system organizing cortical activities in mitotic and postmitotic cells. Required for the normal functioning of the plasma membrane in developing pollen. Involved in the regulation of cell expansion and embryo development.
Subcellular Localization:
Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center. Nucleus, nucleolus.
Sequence:
MSRQAATTHLHKSKTLDNKYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIPQEDLNIIMQEIDLLKNLNHKNIVKYLGSIKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLTEADVNTHSVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDVQPPIPEGLSPDITDFLRQCFKKDAMQRPDAKTLLLHPWIQNSRRTLHSSLRQTGGSIRNIEEDTKLSDGNSNADNHNGSESPSAEKTKIAISDLEHEESKKEHFATDAIHTKGSDGDQNSSLVQNACWNGVEDRAEDVVSAKDPTLVIYEKPSLKSPAKEANLGSPVAPEGKGGTSPDESSMFSFGSKVGRNNFQKVVKQSITHGANELSRFSDTPKDASLDDLFQPLDRQKDQGAEASSSATGQQNDLAKKLKARMAQKQMEPAQNSGGKLLQLVMNLQEDGIDFDGSVFGDNLPADNTFPIQSVEFSKIVGLLKPEASEDVLLSACQKLMVFFTQRAEQKHVYMSQHGFLPLMELLEVPKNRVICSVLQVINHIIKDNIGFQENACLVGLIPVVMNYAVPDRPREIRMQAAFFLEQLCQSSTLTLQMFIACRGIPVLVGFLEADYAKYRQMVHLAIDGIWQVFKLQQLTPRNDFCRIAAKNGILLRLVNTLYSLNEATRLASIGSGGVSLPPNGSAPRPRSGPLEPPNRPSVVQFDSAVSNLGQIDASKVRLEHPFQSGAIEQVQNPASYSQRTDATQLDKQLFGGDKNHPSHAMLEASKENEHFSLWDHEPSRVDIDLPRHQRGTNSAGRSSTDKPPKHMEFASNGHSGGASQLISQHDQIRPLLSLLEKEPPSRHVSGQLDYVHHLSGLERHESILPLLHASTERRTNGELDFLMAEFAEVSRHGREIGITDPNMKLSNKTTKKVLPTMGSSSSNEGVSTSGLASQATSGVLSGSGVLNARPGSTTSSGLLSQMVSSSNADVAREYLEKVADLLLEFAQADTIVKSYMCSPSLLSRLLQMFNKMEPPILLKILKCINHLSTDPNCLESLQRADAIKYLIPNLELREGPLISQIHNEVLNALFNLCKINKRRQEQAAENGIIPHLMNFIMSDSPLKQCALPLLCDMAHASRNSREQLRAHGGLDVYLNLLEDEAWSGTALDSIAVCLAHDNDQRKVEQALLKKEAIQKLVKFFQNCPEQYFVHILEPFWKIITKSSRINTAMAINGLTTLLVARLDHQDAIARLNLLKLIKAVYEHHPRPKQLIVENDLPQKLQNLIEERRDGQRSGGQVLVKQMATALLKALHINTVL
The following text describes a protein:
Function:
Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (F16A11.2).
Sequence:
MPSTSMIEDRSEIERRRFEYLDHPADIQLHSWGSTMEEAFEACLVSMFGYMTDLAKVDEMYEFYWKASGDSLDGLLFQFLDEALNSFHAEPCFVAKRVEILRFDKKKFEIEFRGWGESFDTSKHETEADIKSPTYSNMQINEKPERCDIYVIVDI
The following text describes a protein:
Function:
Probably linked to the pathogenesis of listerial infection.
Subcellular Localization:
Secreted.
Sequence:
MKSKLICIIMVIAFQAHFTMTVKADSVGEEKLQNNTQAKKTPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLALSSGGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYVGNPVKEKEIILNSRTKRLVYNIKLIFAEPEVASWIVQVDVETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFDLKHNTDTSFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYEYYKNVHQLESLDGKGGEIDSFVHYGLNCNNAFWDGQEILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGSRDGRIRSIKDPDKYNQAAHMKDYESLPLTEEGDWGGVHYNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKSQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGVN
The following text describes a protein:
Function:
Ubiquitin C-terminal hydrolase involved in regulating actin dynamics and/or endocytosis at cell tips and septa.
Subcellular Localization:
Nucleus. Cytoplasm. Cell tip.
Sequence:
MSLLRWMGMNSPGSTDRRKSTWEAELPKPSIRPETLTDRFYGLTNYGNTCYVSSVLVSLYHLKPFRDSLNSYPLPSAPPNFKSVCTKTNHPESSSSRHSKKKSMENRKSSLYGSNGINSCGCVDISNVGSESGTKHQIVVGESNCSAYGMKENIYTCLKDLYCSVSCCDCRYGICSPERFIQVLRRDNEAFRSTQQQDAHEFFNFLLNSVTETLDEYYGNHSDVMHPKWVHSLFEGTLTSETKCLTCENITSRDESFLDLSIDIENHTSVTSCLRSFSASEMLSSKNKFHCDVCKSLQEAEKRMKIKKLPKILSLHLKRFKYNETQEGHDKLFYTIVFTNEMRLFTTTEDAENAERMYYLSSVIVHVGGGPHRGHYVSIVRTKTYGWVLFDDENVTPVNENYLQRFFGDQPGQATAYVLFYTAADEEDDDVSEVDTKESIKPMSIPSQLKQESVEVSNLSSTPRSNSTITYPDMDPMVASFSSQYSHKTLDRDINSRSYFDREPSLDAERFHSRSVDASPKAVRRESRSFFPSLTRKRSKFFGSSQSNSPKDSPLRDTHKSSDEHSESKHSHTLPWQFSRSRSKR
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Domain:
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MAEYTHYFIQYNLTDIFYEDVNIEKYSCSICYESVYKKEIYQCKEIHWFCKTCWAESLFKKKECMICRCIVKSISELSRNRFIEQDFLNIKVNCPNSFKYIDENKNNNNKIKDLENGCKDIITIGEIEKHLKQCKFTHIKCKFIGCNKIIRLNQVEKHEKEQCEFRLEYCRYCDTDGITSRSLENHYKECPKFIVKCSENGCTVQLERSQLESHIEKQCQMVMIDCPYKIYGCEQSNRFPKSNLTQHLSSINHTLAMGSMIESQSLQIKETNIKYENLLNKINKLEQLETESKCDQLYDKFYQFESKIDKKLNNLQLDLYPKDNQQPQQKEQKEQKEQKEQQERIKFDDLFEKVSKVNSYFINGCLLKYKNRWSISNYLTESRKYRKITSPSFKIYDKKFKLVIYPQGKDDGSYTSLFLKSDSINPIKVFYKFVLLNFKDESKNLIFKNKSIMDKEKSVGCHYFIKSTEPGKKPEVWLKDDSLVIDFSIEVNINNDIKPLES
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MQTKKKSSGRTAAREHASPKVTRAQKKAYENVQLVEKKVADLITSSARKQRVGGTHKKNGEPVTATISTMNYDSMCDETAETCLEHDALSDGCIENKGCKEETADCMLGTIFSPSFHISKHTNGEPANEVDFVKFFRNEDHNFHQECEIKYSRVDVLNGHVVQETSESLVRDEKSYYENTLSSVNITYPVVEAAGISSEVSAIYLAMKNSKLECVDEHGQEPMSTDLYTDDDEFDEIDDFDPYLFIKNLPDLSSVVPTFRPMLLPKQTRSCPPTSLVLDLDETLVHSTLEPCDDADFTFPVNFNLQQHTVYVRCRPHLRDFLDRVSTLFEIIIFTASQSIYAEQLLNVLDPKRKIFRHRVFRDSCVFVEGNYLKDLSVLGRDLSRVIIVDNSPQAFGFQVDNGIPIESWFDDRSDKELLLLLPFLESLVGVEDVRPLIANKFNLRERVAAAVYPLNSCRGDPFER
The following text describes a protein:
Function:
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWNATPSEEPEPNVTLDLDWDASPGNDSLSDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGSSLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
The following text describes a protein:
Function:
Could be involved in a ubiquitin-related process important for DNA damage tolerance.
Miscellaneous:
MISCELLANEOUS: Present with 7430 molecules/cell in log phase SD medium.
Sequence:
MDMKVEKLSEDEIALYDRQIRLWGMTAQANMRSAKVLLINLGAIGSEITKSIVLSGIGHLTILDGHMVTEEDLGSQFFIGSEDVGQWKIDATKERIQDLNPRIELNFDKQDLQEKDEEFFQQFDLVVATEMQIDEAIKINTLTRKLNIPLYVAGSNGLFAYVFIDLIEFISEDEKLQSVRPTTVGPISSNRSIIEVTTRKDEEDEKKTYERIKTKNCYRPLNEVLSTATLKEKMTQRQLKRVTSILPLTLSLLQYGLNQKGKAISFEQMKRDAAVWCENLGVPATVVKDDYIQQFIKQKGIEFAPVAAIIGGAVAQDVINILGKRLSPLNNFIVFDGITLDMPLFEF