lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Couples the transferosome to a type IV secretion system. Probably forms a pore through which single-stranded plasmid DNA is transferred to the secretion system. The last 37 residues are important for determining plasmid specificity and transfer efficiency, with additional specificity conferred by the TraD-TraM pair.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSFNAKDMTQGGQIASMRIRMFSQIANIMLYCLFIFFWILVGLVLWIKISWQTFVNGCIYWWCTTLEGMRDLIKSQPVYEIQYYGKTFRMNAAQVLHDKYMIWCSEQLWSAFVLAAVVALVICLITFFVVSWILGRQGKQQSENEVTGGRQLTDNPKDVARMLKKDGKDSDIRIGDLPIIRDSEIQNFCLHGTVGAGKSEVIRRLANYARQRGDMVVIYDRSGEFVKSYYDPSIDKILNPLDARCAAWDLWKECLTQPDFDNTANTLIPMGTKEDPFWQGSGRTIFAEAAYLMRNDPNRSYSKLVDTLLSIKIEKLRTYLRNSPAANLVEEKIEKTAISIRAVLTNYVKAIRYLQGIEHNGEPFTIRDWMRGVREDQKNGWLFISSNADTHASLKPVISMWLSIAIRGLLAMGENRNRRVWFFCDELPTLHKLPDLVEILPEARKFGGCYVFGIQSYAQLEDIYGEKAAASLFDVMNTRAFFRSPSHKIAEFAAGEIGEKEHLKASEQYSYGADPVRDGVSTGKDMERQTLVSYSDIQSLPDLTCYVTLPGPYPAVKLSLKYQTRPKVAPEFIPRDINPEMENRLSAVLAAREAEGRQMASLFEPDVPEVVSGEDVTQAEQPQQPVSPAINDKKSDSGVNVPAGGIEQELKMKPEEEMEQQLPPGISESGEVVDMAAYEAWQQENHPDIQQQMQRREEVNINVHRERGEDVEPGDDF
The following text describes a protein:
Function:
Probable mitochondrial adenylate carrier that catalyzes the transport of ATP, ADP and AMP, but not ADP-glucose. Recombinant BT1 shows a unidirectional mode of transport in intact E.coli cells. May function as a plastidial nucleotide uniport carrier required to export newly synthesized adenylates into the cytosol. May be involved in abiotic stress response.
Miscellaneous:
MISCELLANEOUS: The growth retardation observed in plants silencing BT1 is circumvented by adenosine feeding.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein. Note=Dually targeted to mitochondria and plastids. The N-terminal extension acts as a plastidic transit peptide. Dual localization of BT1 does not seem to be due to alternative transcription start sites, translation initiation sites or alternative exon splicing.
Sequence:
MGKTGIQLFDDSRNGFFSVSDLGFDSSLNSSNYHPIGGLFASVNQTNPFASLSSSDLSNRGNNSFSTQLNDLYTKYMPGKEEEEEVVNGEKRKRKKKGGLTLKIKIANPSLRRLLSGAVAGAVSRTVVAPLETIRTHLMVGSGGNSSTEVFSDIMKHEGWTGLFRGNLVNVIRVAPARAVELFVFETVNKKLSPPHGQESKIPIPASLLAGACAGVSQTLLTYPLELVKTRLTIQRGVYKGIFDAFLKIIREEGPTELYRGLAPSLIGVVPYAATNYFAYDSLRKAYRSFSKQEKIGNIETLLIGSLAGALSSTATFPLEVARKHMQVGAVSGRVVYKNMLHALVTILEHEGILGWYKGLGPSCLKLVPAAGISFMCYEACKKILIENNQEA
The following text describes a protein:
Function:
Small GTPase-like component of the intraflagellar transport (IFT) complex B.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MLKAKILFVGPCESGKTVLANFLTESSDITEYSPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDAKFESCWPALMKDAHGVVIVFNADIPSHRKEMEMWYSCFVQQQSLQDTQCMLIAHHKPGSGDDKGSLSLSPPLNKLKLVHSNLEDDPEEIRMEFIKYLKSIINSMSESRDREEMSIMT
The following text describes a protein:
Function:
Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR).
Miscellaneous:
MISCELLANEOUS: Although FhcB and FhcC do not possess a formylMFR dehydrogenase (Fmd) activity and have an unknown function, they are required for the stability of the complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAWVKGGAADVDAAVEAAADLLAASRVPVLAGLSAEVSALRAAYRLAETLGASLDPVSGPSVYAELGALSAGGAMSTTRAETIGRADVILIVGNRPWDGELIAEIAAAAPSRGRAAGSERALLSLGGPQNGAIRHVAYAADAGGLTISLGHLRAFAKGHLAGEAAFADLAKRLFAAQYGVIVYDPEEVGELGAEMLQGLIRDLNESTRFFALTLADPFQGRAAVQLSAWTTGQAPRVGFGRHQPEHDSWRFDSARQIAAGEADAALWLASLPAPRPAWLGSLPTIAIVGEGSQEAAGETAEVVITVGVPGQSVGGALWNDRRGVIAYAEASDPAKTPAETETAAGVLTRIRDRLIEKGVSC
The following text describes a protein:
Function:
May play a role in apoptosis. May act as a tumor suppressor.
Sequence:
MGNLNFRAQHKEEPRVVIMGLDSAGKTTLLYRLKSNQQVETYPTVGFNVESLEASKHGSLTLWDIGGQDQLRSSWKDYLEDTDSLLYVLDSTDEDRLPEATVELENVLNNAHMVGVPFLVLANKQEVPGALSLLEIRDRMQLDRFNDRCWELRGCSALTGEGLKEAQLALERLLQSRKQLCLYTMQVNGERKKS
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MSRRPNLRSTKLALNQKVSIIPTDAVKAEPPSSKLTYSSLRRPTRSSATVEELASPVKKNKLNIAKYEYKGSIPSPRKRPRIDDVVKEEEIETKASPIKSPAKKPLPQVALAKPHAAPAKWEEQYRLIEKMRRGIVAPVDDMGCERPRTNTEGDPKTFRFHILISLMLSSQTKDAVTSAAVTSLHTSLPGGLSAASLAAAPLETIQECINKVGFWRRKAEYIQEAAKTLLEQEGDEKGDVPKTVEGLCKLKGVGPKMAFLALQCAWDINAGIGVDVHVHRITNRLKWHRPPTSTPEQTRLNLQSWLPPHLHKPINPLMVGFGQVICLPVGPRCDICLLGQKEICPSRVKGANAKGRKEVTYSFKEEEDELAIGQWRWGQAKGVKSEAKVEIGYEGGLEKIKDEEPENSVEVEQMIKEPGMRRPDEVLEVLDQVDGPTDIGAEPVIKTENVDW
The following text describes a protein:
Function:
Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MTPRHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRGRTVVTMFYENSTRTRVSFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGADALIIRHPASGAAHLLAQWTGAHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRIVIVGDILHSRVARSNVMLLDTLGAEVVLVAPPTLLPVGVTGWPATVSHDFDAELPAADAVLMLRVQAERMNGGFFPSVREYSVRYGLTERRQAMLPGHAVVLHPGPMVRGMEITSSVADSSQSAVLQQVSNGVQVRMAVLFHVLVGAQDAGKEGAA
The following text describes a protein:
Function:
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MNAIAPQVSPVSVSALPSAAELDRALRDASPAEVIAAALKAVGRDKLALVSSFGTESATLLKVMADVDPSIPVIFLDTGWLFEETLAYRDMLIATLGLKDVRSIRPAEETLSREDPDRDLWFSDPDACCRIRKVEPLARALKPFDAWINGRKRFQGNARADIPVVEDDGARLKFNPFANVSREELEAIFVRAKLPRHPLAASGFLSVGCMPCTSRTAEGEDARAGRWRGRAKTECGIHTMKTS
The following text describes a protein:
Function:
Copper-sensing transcription factor that regulates iron uptake genes. Under copper starvation conditions activates the transcription of the copper transport genes, ctr4, ctr5 and ctr6.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic in presence of excess copper ions. The Cys-His motif (328-342) interacts with the N-terminal nuclear localization signal region leading to sequestration in the cytoplasm. Nuclear under copper starvation conditions.
Sequence:
MVVINNVKMACMKCIRGHRSSTCKHNDRELFPIRPKGRPISQCEKCRIARITRHLHVKCTCNSRKKGSKCSTSSTTDLDSSSASNSSCSIPSSISEKLLPRDNVKTHCPKRSASCCGKKPDVMPLKINLESQTDFMGMPLQSQRPHSESYRMLPEPEKFKSEYGYPSQFLPIEKLTSNVAYPPNYNNYLKSPYQQPTNFPPEIQYNYSHSPQHSIQEAEEAAVYGPPVYRSGYQILYNNNTDSIAAAAATHDLYPQPDVPLTFAMLADGNYVPLPSSTNTYGPSNSYGYEININESTNHVDSSYLPHPIQLSNYFTLPSSCAQADAACQCGDNCECLGCLTHPNNATTLAALNHISALEKETISHTDLHHTFKHEVNSSNNYELTNDELAASSPLYTSSSVPPSHITTGST
The following text describes a protein:
Function:
The H protein shuttles the methylamine group of glycine from the P protein to the T protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST).
Subcellular Localization:
Mitochondrion.
Sequence:
MASARLVNAVASKAFKSIQYSRVGFLSISQSNGLLKSFKPHCRRIHTTQLLSDKLFTKDHEWVSIENGVATFGITDYAQEKLGEVVYCELPEVGVECDKDDVIAVVESVKAASDIFAPVSGEVTKANESLVTSPGLINASPEDSAWIAKIKMSNDSDTDGLLNESDYKKLIVSLE
The following text describes a protein:
Function:
Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRLHAFTLLSLLGLVPSFAAASLSGSVGPLTSASAKAAKKTCNVLDYGAKADKKTDLGPPLAAAFAACKSGGLVYIPAGNYAMSTWVKLANGKAWALQIDGVIYRTGTDGGNMIMIEHTSDFELYSSTSSGAMQGLGYELHAANNWSGPRLLRLWDVSDFSVHDLILVDSPSFHFSIDTCSNGEVYNMAIRGGNHGGLDGVDVWSTNIWIHDVEVTNKDECVTVKSPAKNILVENIYCNLSGGCGMGSLGADTDISDITYKNIYTWNSNQMMMIKSNGGSGTVSNVVLENFIGHGNAYSLDIDSYWSSMSAVSGDGVELSNITIKNWKGTEANGAQRGPIKIICPDKVPCYNILIEDFAMWTETGSKQWYSCQSAYGSGFCLKSGSHHTSYAVTTTTVSSAPSGYSAAKMPLDLSTDFGSTQSIPIPTIPTSFYPGATPYSALMSKQSTKAAKARAVDMSVETPAAASRSEQVVQGASQETSQPAPESAGPVRSVPTGGNRPSRHRHGHHHFWIAA
The following text describes a protein:
Function:
Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Part of the Notch signaling pathway.
Subcellular Localization:
Nucleus.
Domain:
The orange domain and the basic helix-loop-helix motif mediate repression of specific transcriptional activators, such as basic helix-loop-helix protein dimers; The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
Sequence:
MEYTTKTQIYQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQQKTPKKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQPMQQPLWRPW
The following text describes a protein:
Function:
Key regulatory enzyme of the glycolytic pathway that catalyzes the final step of glycolysis, converting ADP and phosphoenolpyruvate (PEP) to ATP and pyruvate by essentially irreversible transphosphorylation. Is critical for plant growth and development.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MHSTNLLLEEPIRMASILEPSKPSFFPAMTKIVGTLGPKSRAVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKLAIKSTKKLCAVMLDTVGPELQVVNKSEAAISLEANGTVVLTPDQGQEASSELLPINFSGLAKALKPGATIFVGQYLFTGSETTSVWLEVSEVKGDDVVCVIKNSATLAGSLFTLHCSQIHIDLPTLSDEDKEVIRRWGAPNKIDFLSLSYTRHAEDVRQAREFLSKLGDLSQTQIFAKIENVEGLNHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVVTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLRWSFTGAFEARQSLIVRGLFPMLADPRHPAESTSATNESVLKVALDHGKASGVIKSHDRVVVCQKVGDSSVVKIIELDD
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MTSASSAPSSPGASSASDDFAAMLDEELQGSLEETGVVLEEVGEDADVEVDDDDEAEEEPEQEDVALETDPGEDSVVEEDEEEEEVDVENAGNNEKPDDFGGENGERLGKATASKEDYEVREEMEGRKRKREEEDDKRDPKNAKGVCPPHPGFMWGVCIRCGENRQTSNSEPAEIGVALRYIHEGLEVTEREAARMRRDELKHVIARKKLYLVLDLDHTLLNSARFIEVPPDEEAYLTACYSKARSAKSEQASGSHRGASGPQGTVDSGYNHGLNRLNHLQMWTKLRPFVHDFLDAASKMFEMYVYTMGERTYAVAMARLLDPTGRFFGDRVISQGDSTRRTTKDLDVVLGAESAVVILDDTEGVWPKHRPNLVLMERYHFFRSSCRQFGLKGLSLTDKRKDESEEEGTLATALGTLRSLHHAVFNESAERGSSKRNSTNVEDVRKVLQTLRKRTLKGCRVVFSRIFPSGMPDMESHPFWRLTEELGATSSNTLHPSATHIVALDRGTDKARWAKKHGKFLVHPAWVEAAQYLWCRPREEDFPVAENNPEPPLIAFAKTIDRIEEESRSSAPENGMSVEDTSQISDVKGETNGEGEPHGLDGAQKSEEKPVLDTAKASLLINEAPEAVV
The following text describes a protein:
Function:
Participes in the structural integrity of both centrioles and basal bodies and in centriole cohesion. Participates in the later stages of centriole assembly through the interaction with Rcd4 leading to the centriole to centrosome conversion.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Associated with the daughter centriole on mitotic entry. Ana3 recruitment to the procentriole in interphase precedes the Rcd4 one. Localizes to the basal bodies.
Sequence:
MSTKQSPALQLAEGQLTKLTSESEEIRMRALDQIETRFIRCLQLGEPIQFKPVLLLKQLIRWFGYTPPLVPDRVLAMIMELLRSEYAEAVIRKIPYERFKAELQKVRRVLHKQESKRVSELLDDMNLLLLEKYNIDRVTPSVSSLSSNDIPSQATESADSSSNQIYDNLKPEDYEPSWSHPCLDDVATMKSMIDLPRNSVELQLQLTELIIRMGDYPTEYFLQPPFVFLHLVQLQTMTDGSLIHVNRALIACLRLLQQRILLRRNTLSYADRFDPPSRPKQVKVVSALVILLENCMKLIRPLLFSCTNDNWHIMELIVEIVRTHDVLSSKIPLVSITLIADAVKSLLAYCNSVEGSCMTQLMDSLRIPRLQSLILNGVLHDMVALNINYDKRMDRRQAKALIQPIVLDSAYLSGMPERMKSLNTLISSLDSGPSPDEELIKLKRAYSVALNQLHPNTELTGSLLIQKYRQVCLVLVQLGSETLVKQLFGAVVKCIPFYAGNLKLRKDADELLYTLVDLPALKLRSLIYRLMIKSTVAHFHSFMNKTVYMTGCSNVDLIRQHILGVPLTPLLLRRMIIQSSEANTSERMQQWCLDYPIMIMKLNAILAPQDFSVVFPLLLPVLPLLISRSVTHKILHNVIWNVLEPDSSRLDPQLMLRGYVYFMFHPDGEVRSEATTTIAYVLQCQEQTNRYLPTASNVPVEHIANDLCIIQPPFCYRSIFIKCSDERFQGQRSLDALFRLLQAKDIKSNIRKSTMTQLNVLLRNWRACEEFSTKEDGYRLIMESLHNALKKGNDTDILLPTVSILMKLLFNDDEFRLEVANTFGVYTLLLRALFLFPHLEQLRQDVSICLFQMLFQNCITSTEDKLVLNANMEPLILPVTYEIEHKVIPTAVTEGLELQQNVEATHFGRDRAKAAQHWRLYMAYRVCQVPSSITLESVSALDIRESLKIKMADLALVRSSDLNEQLSCQFIAAENCSKHEDLQKTVSAIQLFLVVLRNSLSDTVAENLWKLIHKYIRLAPGNEADDKVYKSMLDLCVTCIRFSQPHAINGLSYALETDHHHSFQLLLHDSQISLDKLFLICQCMMQLLSNELSDDSMNWYGKFFMQLSAVAKTHFELRQLQHVRCILCMLRFVSERNLKFSNAQLMSYSQHFIQLSSNLRTSTQTGSEWQRDCLYIICQLQIHLIYQEPKASSKASIPNDVGASYKVLRYFLTLCGHGDSEVRALSWVSLANWITICGSQVAEILPRLDFLPGGLPACCLTTLTDAHEMMLIRELAGRVFILLMPLIGAESSLELLRKHDLLKTAYNSLKAIHDTPWMFKKIVGERHSCEVISCYVAICTKMVAMKPEWCAALCGHSLMSGLSDVMKKLKSQASCSIPLVELCASQICELYSMCYTNNFEFLKMTICRDSVFLQNYLTLINDVLSLECPEYMVIPLLKMFLIFCTDSNSNSFLIEQIKNKPSLFMDFFLFGLHVKLINSPFQRFTLSALSLVFTKAQLAAYDISMLSELEKFELAFSDPDIAKDGKQEFESKKKQSVSQCIYDESSDNSDDNKQRPNHAIQATNAAIIIFHRLDQLFDRYYLSKALNFLELPAVGQVQVCEALGELLKASTWAVKAAGESKLLGKVVHILDDFLNDEKIGNAAVYVKRVGPHKAQSIISNLLVLINMLSQWHSSPNSEIIQTSMAANIAKILIRIWPWLSHSYHLKKVTVQLIMFLTEHSFEMCKQISLLQSGHAQSLLHLMARVADFETTKKEIPNKEPSLNMVPALRVMVNCCCCTEGRLSLSKMNLLDMFDTILPANPCSTHLKVRPPVLIAWLGFWEVFSRYDVGGKACHLQSLINTIRRSPPLSHKRILCLRILRNMCFFNGNRPRLVELADFINLLRDILEQRVQKAPTSEKNGLNSFEEHRLAVLMLWKLFGFGAKYKGMLRGTKLFKLLIGLRVEMSVVFSEEENKYAGVPYANDLAKLLEKLMESMRQ
The following text describes a protein:
Function:
Component of the heterodimer clotting factor G which may play a role in defense mechanisms against fungi (Probable). Initiates a (1->3)-beta-glucan-sensing clotting pathway whereby the alpha subunit binds to glucans containing (1->3)-beta linkages, which are components of the fungal cell wall, and the beta subunit catalyzes the activation of proclotting enzyme.
Sequence:
MDISFLVFITLSMALFSSNVTGTSVTSRVRRGINEKHCGFRPVITRIIGGGIATPHSWPWMVGIFKVNPHRFLCGGSIINKVSVVTAAHCLVTQFGNRQNYSIFVRVGAHDIDNSGTNYQVDKVIVHQGYKHHSHYYDIGLILLSKPVEYNDKIQPVCIPEFNKPHVNLNNIKVVITGWGVTGKATEKRNVLRELELPVVTNEQCNKSYQTLPFSKLNRGITNDMICAGFPEGGKDACQGDSGGPLMYQNPTTGRVKIVGVVSFGFECARPNFPGVYTRLSSYVNWLQEITFGQSLASLFEVVPIFIPE
The following text describes a protein:
Function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Subcellular Localization:
Cytoplasm.
Sequence:
MISVTLSQLTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDIDLPQLIVKDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANVGSMTAAVQVLAEMPGYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSHAISTASGVGEHFADKTALITRLKLLIAEQQVITILVKGSRSAAMEEVVRALQENGTC
The following text describes a protein:
Function:
N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L.
Subcellular Localization:
Mitochondrion.
Sequence:
MKLWGQILWTLLSVPRGRRGVLQGWAFNSWKTYSSLTGPLSATGMVNHWTRVFEERGIPEARESSEYIVAHVLGAKTFQSLKPALWTKPLTPQQLECIQELCGRRLQRMPVQYILGEWDFQGLSLKMVPPVFIPRPETEELVEWVLEEVAQRPHAVRAQDGPLILEVGCGSGAITLSLLSQLPKSRVVAVDKEEAAVSLTHENAQRLQLQDRIRIIHLDITSEGCCTHLLPWSPLDLVVSNPPYIFRKDMEQLAPEICSYEDLVALDGGDEGMDIITHILTLAPQLLNASGSIFLEVDPRHPELVSSWLQSHPDLHLSLVGVREDFCGRPRFLHVQKSAP
The following text describes a protein:
Function:
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MCRNSQVEASFFQVLSEANLNIDFVQSPNRGKRVIFAKFVKTSCRITFPDNEEKKDVNKKILVPDSDPPSTTDVKLLYQFFDKSTNLMVLTGAGISTECGIPDYRSPNGAYSSGFKPITHQEFLRSSRARRRYWARSYAGWRRFTAAQPGAGHFALASLEKASRINFMLTQNVDRLHHRAGSNPLELHGTVYSVICLDCGFSCSRNLFQDQLKALNPKWAAAIESLDYGIPGSDKSFGMKQRPDGDIEIDEKFWEEDFHIPTCEKCNGVLKPDVVFFGDNVPKDRADKAMEAARGCDAFLALGSSLMTMSAFRLVRAAHEAGATTAIVNVGVTRADNFVPLRINARLGEILPRVLDAGSLSIPAP
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MDKILEAVVTSSYPASVKQGLVRRVLEAARQPLEREQCLALLALGARLYVGGADELPRRVGCQLLHVAGRHHPEVFAEFFSARRVLRLLQGGAGPPGARALACVQLGLQLLPEGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCIPDGPHRLLFCQQLVRSLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCTEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSAPEEPPSPSSTSVEKMFGGKIVTRICCLRCLNVSSREEAFTDLSLAFPPAERCRRRRLGSVMLPPEEGPGKVGPRRQRKHCITADVPPAILDMAGLGHQGPGGQSLQEEKGEKEERAEEEEETREGEDEREKGEPKGEEEEEEEEKEAEEKEEADSLGPGTLRNAAVPSAEGSRSVLDLVNYFLSPEKLTAENRYHCESCASLQDAEKVVELSQGPRYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGGRGQAYDLCSVVVHSGVSSESGHYYCYAREGAARPAPSLGAADRPEPDNQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPGEGPEAEPGSPRARAEPALHKDLMEAISKDNILYLQEQEKEARSRAAYISALPASPHWGRGFDEDKDEDEGPPGGCNPAGGNGGDFHRLVF
The following text describes a protein:
Function:
Transporter involved in the uptake of sterol.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSISKYFTPVADGSLTFNGANIQFGADAQGESKKSYDAEDSMPNPANQLNDITFQAEAGEMVLVLGYPTSTLFKTLFHGKTSLSYSPPGSIKFKNNEFKSFSEKCPHQIIYNNEQDVHFPFLTVEQTIDFALSCKFDIPKGERDQIRNELLREFGLSHVLKTIVGNDFFRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKFDKILMLSDSYQLFYGTVDECLTYFRDTLGIEKDPNDCIIEYLTSILNFQFKNKNLGNLSNSSSASVLKTATGEVTKYTYNSDFDLYDQWKHSSYYRNIKQQIQGSSIDDSIKEVDPSDVSPIFNIPLKKQLLFCTKRAFQRSLGDKAYMTAQFISVVIQSLVIGSLFYEIPLTTIGSYSRGSLTFFSILFFTFLSLADMPIAFQRQPVVKKQSQLHFYTNWVETLSTTVFDYCFKLCLVIVFSIILYFLAHLQYKAARFFIFLLFLSFYNFCMVSLFALTTLVAPTISVANLFAGILLLAIAMYASYVIYLKNMHPWFVWIAYLNPAMYAMEAILSNELYNLKLDCSETIVPRGPTYNDVPFSHKACAWQGATLGNDYVRGRDYLKQGLSYTYHHVWRNFGIIIGFLVFFIACTLFASQYIKPYFNKDEIERNNSRLTRWLPFLNKKRGTRSSARNDSKYVGIPKSHSVSSSSSSLSAVPYQISPSNKEMALNDYNEQPITETVETQKHIISWKNINYTVGTKKLINNASGFISSGLTALMGESGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKESLEISCLLRGDGDRAYLDTVSNLLKLPSDILVADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARLEDDARASGVDYTTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHIKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKEVYVAREARSNTYHWTVLLLSQSIIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNYMLFAAYYSTLGLWLIYTAPNLQTAAVFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVSPYTYFVETFVSILLHNWEIKCDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVCAYCTYTVGDDFLKNENMSYDHVWRNFGIEWAFVGFNFFAMFAGYYLTYVARIWPKVFKIITKVIPHRGKKPVQN
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence:
MASLLTAADRQNSTTQSPQSLSGSCSPRNAASPNANATAAATTAGGQPTAGGGGNTAVALNNPTAVKLGVMDVPKALQDGEKFIKWDEDSCNGTPVTLRVDVKGFFLYWVDQNHEMDMLDIATIRDVRTGQYAKKPRDMKLRQIVTMGSQDTLEEKTVTVCYGADFVNVNFINFCCTRKEIARLWCDELIRMAYNLTQLNGPAIMFLQKAYTKLCLQVDKSGKIPVKNIIKTFATNKDDRRRVEKALDVSGLPSGKGDTLALTKFQFEDFFNLYKNLSQRTEVEKVYDELVGTSKRRLMSTSQLVDFLNKTQRDPRLNEILHPYANTARARDLIQEYEPNKFNAQKGKLSFDGFLRYLMSEDNPIMAASKLDLSDDMDQPMAHYFINSSHNTYLTGHQLTGKSSVEIYRQSLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEICAKDVLEAIAETAFKTSEFPVILSFENHCNPRQQAKIANYCREIFGDMLLDRPLDSHPLESNVELPPPALLKRKIIIKNKKKHHHHHHHHHKKAATVVSSPQQPPPPAGTTVVANNVSNSNSTAANAHATAVNNSSANSTNAASNTPGVTPAVNSNSTNAANPSLPPSQQDEPNGTVVVSNNNGTAAPLQATGNGEIPHHAPPLQQIRQSSKESTGSSDTDSSSDDESMPGTVVGPIGASEADKVPQTKETEAGAEISALVNYVQPVHFSSFENSEKKARFYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNYQTLDLAMQLNLGIFEYNHRCGYILKPEFMRRKDRRLDPFAESTVDGIIAGTVMVTVISGQFLTDKKVGTYVEVDMFGLPADTVRKKFRTKIVRDNGINPVYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHLTLRTEVGQPIPLATLFLCIVVKDYVPDGLSDFAEALANPIKYQSEQEKRSKQLAVLQEDMEPSDEDSFVVVSLGTNKKGDTLRSSETNNTTSSPARQRSVAGTQSSQGGAGGTADSDAEAPLEAITKMVALPVAQSSSLDHSNVPAAKISTTSREPTTTGGGGGGSGAPIITTTTNTPNVATGEGLNAANGGKIVADPLEKIFEDKQIRKKREALEKELKALKKSHDKEKLKIHAAQKSTDLGGGDAPVKKSKFGMGNKLVKRFSSKNMADMNVKVPPCASVSDAEGTGDAQAERLRQICRDHAGSYREVLEKYHDIIYTLAEDLLRQSQDAQMKQLKTQLERETSEVMRQLQLSRKSEVKQLAMVHKDKDELERMKREVDSTLVEKGVTERVRLTATYERKRDELQRQHDSVKQGLEDHKLKARSMLEKEAESHAFISDTFLAHLNTSNSTTSCSSVGATTNHPPATSVSSGNICGAGGTAGSTHENNVNNAHA
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Subcellular Localization:
Mitochondrion.
Sequence:
MASHLLNHSSKMRNASKLLHHERALLVRWFSGDAQSSLNRNRDVWKTQFHESSTTRSVFEPASSFNKRSFGMQKRNISMATIKRGSIIGFGFNGEISRSSQVLSRRCYASASDLPPHQEIGMPSLSPTMTEGNIARWLKKEGDKISPGEVLCEVETDKATVEMECMEEGYLAKIIRGDGAKEIKVGEVIAVTVEDEGDIAKFKDYQPSASEPSAAPAKEISAPPTPKKEEEVEEPGREPEPKVSKPSAPPSSGDRTFASPLARKLGEEKNVPLSSIKGTGPEGLIVKADIDDYLASGAKEVSASSKAKVATDAALDYTDIPVSQIRKVTASRLLLSKQTIPHYYLTVDTCVDKLTSLRTQLNSLQEASGGSRISVNDLVIKAAALALRKVPQCNSSWANDYIRQYNNVNINVAVQTDNGLFVPVIRDADKKGLSTIGEEVKQLAKKAKENSLKPQDYEGGTFTVSNLGGPFGVRQFCAIINPPQAGILAVGSSERRVVPGSGAEEFKFASFMSVTLSCDHRVIDGAIGAEWLKAFKGYIENPETMLL
The following text describes a protein:
Function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Sequence:
MSASVPAPAANQDYKASLLPLLISNNVLSFGTYTLKSGRESPYFFTSSLLHTAPLLRATSAAYASVLSAEPFVKTATDGTLSPNFDIIFGPAYKGIPIAAAVTNELAVRDSIAGTHTWDNVSYSFNRKEAKGHGEGGNIVGAPLKGKRVVIVDDVITAGTALREAVGIIQKEGGIVAGVVVLLDREERVSEAEPKSAVGVAQRDLGESIPIRAVIGLHDLIEKLGDKIGESEIQRLKDYRARYGAE
The following text describes a protein:
Function:
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives.
Miscellaneous:
MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome.
Sequence:
MSTAVTFFGQHVLNRVSFLRCSKEFIKKSLNHDSTVFIPFIEGEALISPENGDLVQLSNSVKSYKNILSAIVPLYTTLLNTTRSRSDESGINVTFLGLLEGTDSAFNFEWSNISYKGTPYFGLDIRVTESTLFKKVDFEPIFSYPKVTRDHIFKQTNEDASLYSQGKMYLDWLAKYKFCPGCGSPLFPVEAGTKLQCSNENRNVYCNVRDARINNVCFPRTDPTVIIALTNSDYSKCCLARSKKRYGDFVLYSTIAGFMEPSETIEEACIREIWEETGISCKNIDIVRSQPWPYPCSLMIGCLGIVQFNSKNEVINLNHDDELLDAQWFDTTEIIQALDKYAGGYRVPFKNDINLPGSTTIAFQLINHVCENYKNLRKTSSSHL
The following text describes a protein:
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Sequence:
MLCRSVRELIIVGWQGSGSRCAAPRRAACGAGSRGVRRTVSALRPAAARAPGPDNMGLEKERAESSVIMDAEEFNRSIEPILLRKGKGFSEVPDDRDPNDINAHVKVAFEDVIAEPVSTHSFDTVWVGSHAAFELVKFLCYRLLSTLLAVPVAFVLGLMFGVLSCLHIWLVGPVIRGFLTFLPPALTVWRKLMVLFVAPLSHSMGKSMSSIQVRSSENK