lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Sequence:
MELEDQWWRGQLAADIYQALRYKELKLPSFKGQSPQLNLRRYFADLIAVISNHLQLCPPARHLAVYLLDLFMDRYDVTVQQLHMVSLACLLLASKFEEREDRVPKLETLNGLGCMSSMNLVLTKQGLLHMELLLLETFQWNLYLPTAAHYIEYFLSAAVHEGDLHDGWPMTSVEKTKVYMLKYADYFLEVSLQDHVFLCFAPSLVAAACVAASRLTLHLSPTWPPRLHRLSGYTWENLVPCAEKLLIAHDSDVKEDHKQKCRQPVQQQQQQQQQQDQSMYHSSGQSASVAQYLHLSGVQYPQQTLQSGLPSSHYLSQSVASLQPLPGSQHPTSQAPATSLDPKPNRSHQVSMQYSSAASCFDR
The following text describes a protein:
Function:
Probable lipid transfer protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGYRRSYAITFVALVAALWSVTKAQPSSSCVSTLTTLSPCLSYITGNSTTPSQPCCSRLDSVIKSSPQCICSAVNSPIPNIGLNINRTQALQLPNACNIQTPPLTQCNAATGPTAQPPAPSPTEKTPDVTLTPTSLPGARSGVGGGSKTVPSVGTGSSSRNVDPLPLHFLMFAVLVVCTSSFL
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Sequence:
MEPLIFGNLTSPALASNIRSSDLRVTTSIAQIYKPYVFLRYVFLDSNFLMFSFFYKILMAPLLSIFVLLVFVLHVASESTREVVEQIDGEEFTEQLLFRPLPDQKALSDFHFEINTPHTHPQALEPLFVLMGSLEVGFVDTTKNPALALSASGTASVGTVSVPNSVFNSTINDQILAMSFKTDVATIQKIKSGEMDAHFSACGRYLAVCVAFEKPKYIYIAGFFLTVSPEAIQLVVEHATATNKVFTINLSTPFICEFSKDAQEKALPYVDYVFGNETETRTFSKVIGWETDNVEEIAIG
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits.
Subcellular Localization:
Nucleus.
Sequence:
MARARKGALVQCDPSIKALILQIDAKMSDIVLEELDDTHLLVNPSKVEFVKHELNRLLSKNIYNPMDEEENQ
The following text describes a protein:
Function:
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.
Miscellaneous:
MISCELLANEOUS: In contrast to mammals, which contain two copies of MBL (MBL1 and MBL2), chicken genome only contains one copy of MBL.
Subcellular Localization:
Secreted.
Sequence:
MTLLQPFSALLLCLSLMMATSLLTTDKPEEKMYSCPIIQCSAPAVNGLPGRDGRDGPKGEKGDPGEGLRGLQGLPGKAGPQGLKGEVGPQGEKGQKGERGIAVTDDLHRQITDLEAKIRVLEDDLSRYKKALSLKDFVNVGKKMFVSTGKKYNFEKGKSLCAKAGSVLASPRNEAENTALKDLIDPSSQAYIGISDAQTEGRFMYLSGGPLTYSNWKPGEPNNHKNEDCAVIEDSGKWNDLDCSNSNIFIICEL
The following text describes a protein:
Function:
May be involved in vacuolar sorting and osmoregulation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MKLKSVFRSVLKYRKTNLSLLLLITYSIITLLYIFDHERYKLNLPKEDEHPEFNDLLETAWGDLQIITASFHPYTSKENDKVHDYLLKRVLEITGNSSFASVSDDKESERSILFQQQDPFNESSRFSRVTYFESSNILVKLEGKNPEEEGLLLSAHFDSVPTGYGATDDGMGVVSLLANLKYHIKHRPNRTLIFNFNNNEEFGLLGASTYFDHSWSNLTKYVINLEGTGAGGKAVLFRTSDTSTARIYQQSVKENPFGNSIYQQGFYSRYVRSETDYKIYEENGMRGWDVAFYKPRNLYHTIKDSIQYTSKASLWHMLHTSLQLSAYVASNSLDTADQTPACYFDFIGLKFFVISAKTLFYWNCIFLLVSPVVAIGLYLISRDRMTWKSYSWLSWTRFPLSLAAGIIVQKLFSNDIIRSNPLTFSRNYFWPISAFFTQVIFTSYVLINCSNFFFPCADMKSLSIIELFIILWTILLFTSKLLYSSDYRYTGLYPLSIFFLLSTIAAILRLLALALGMRTRKRLGRECRDHHSNYSSHSQIDMERDGQENLEQPQDQLTSSQDDQASIQDDNVSTTSAGPSHNVDEDHGMDSSSQQHDERVPLLKGSNSMEEGLSTRENSLKLEYTDYAWIIQFLLIVPIPSFILFNSVDVIMDALNHTVQEGSKATFDVLRFGMVGSILIALPILPFFYKVNYITISLTALLFLISASKTLLVHPFTNSNPLKVRFSQNIDLSQGNAASVHVLGREGNFLKPMLQDLPSIKYSSTHINCTSVTNGMELCMYDGMQPNLLSTNGNTNISSMVKVHVLHNNRNSTERSPYEPIVAELLLEVKENRACTLTFESRHQAKSPVREITVYQKKNSAPQKANITKTIKSASGINELQLHKLDFDQETYHIGVQWFPKLLTDGNVEDDKLGTKDELSVSISCYWGEYDSESVVNGTAVRKIPAFDELINYAPLSFSFTNEQKGLVIVKDAIIL
The following text describes a protein:
Function:
Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.
Sequence:
MDEEYDVIVLGTGLKECILSGLLSVDGLKVLHMDRNDYYGGESTSLNLIQLWKRFRGSDKPPPQLGSSRDYNVDMIPKYIMANGALVRVLIHTDVTKYLYFKAVDGSFVYNKGKIHKVPATDMEALKSPLMGIFEKRRARKFFIYVQDYNESDPKTHEGMNLTTVTTRQLIAKYGLDDNTVDFIGHALALQRDDRYLDEPALDTVKRMKLYAESLARFAGGSPYIYPLYGLGELPQAFARLSAVYGGTYMLNKPECKVEFDEEGKVCGVTSEGETAKCKKVVCDPSYLSNK
The following text describes a protein:
Function:
Required for the biogenesis and accumulation of native cytochrome b6 in the thylakoid membrane. Controls the conversion of apocytochrome b6 to holocytochrome b6. Required for covalent binding of the c-type heme to cytochrome b6.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MATKLISPPLSCPWVTSREVIIKGLPRRRREWMVTKRNRVSAVTAMIVEPLSVVSSSAIQIHQWWEQNPNSLLLMTEATGGYSLASYYTSLGLFVISVPGLWSLIKRSVKSKIVRKTFVVNDVKKEPKQVAGEILSFFTRKNFNITDRGETITFEGKMVPSRGQAALLTFCTCISLASVGLVLTITVPDFGNNWFFIILLSPLAGVYYWKKASRKEEIKVKMMVGSKGRLDEIVVQGDDVQVEEMRKELQLNEKGMVYVKGLFERSS
The following text describes a protein:
Function:
Catalyzes the reversible isomerization of (R)-3-methylitaconate to 2,3-dimethylmaleate. Has very low isomerase activity with itaconate.
Sequence:
MSDQMRIPCVIMRAGTSKGIFLKGNDLPADQELRDKVILRIFGSPDVRQIDGLAGADPLTSKLAIIGPSTHPDADVDYTFAQVSITDAVVDYNGNCGNISAGVGPFAIDESFVKAVEPMTRVCIHNTNTGKLLYAEVEVEDGKAKVSGDCKIDGVPGTNAPELMDFSDTAGAATGKVLPTGNVVDVLSTSKGDIDVSIVDVANPCIFVHAKDVNMTGTETPDVINGNADLLAYLEEIRAKCCVKIGMAATEKEASEKSPAFPMIAFVTKPEDYVDFSTGNTISGDDVDLVSRLMFMQVLHKTYAGTATACTGSAARIPGTIVNQVLRDTGDEDTVRIGHPAGVIPVVSIVKDGKVEKAALIRTARRIMEGYVYVEKAKLV
The following text describes a protein:
Function:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.
Domain:
Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
Sequence:
MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
The following text describes a protein:
Function:
Essential for the functional mitochondria and respiratory growth.
Miscellaneous:
MISCELLANEOUS: Although initially predicted to be a dubious gene because of an almost complete overlap with MRPL51, it shows transcript and protein level expression.
Subcellular Localization:
Mitochondrion.
Sequence:
MSPSESFNSFSLFSTLSMFKFLTQITFSRPFVYSALNKGCPDFLITSNCIHGNSWPHLSNLFEVKNFLMPSEDPPQLQNCKVIFLHGNTNAPTPLRPMEFRAIAFTTISPYIRVCVST
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MASSSDDDFVILICSNPNPIEAKTPHEEIHISTTDILSWDLPTILSYPTVKVHACRNRLIEKSSYFQGLLCGSFSESCLDSTSIQWNLEIFVHVLKCIYGCPLHFTSKNFVPLFEGALYFGVETLISKCKTWFSEVSSPKGSGSLQIELDDLIHIWIFGLEFANEFLPELCAGYLARNFMWAMTSKVFGDVPYNLLLSCLDHPYLTVDSEMHLSEALLVWLNANSKQLENFSRTGENCRGIFRHVRIGLLPLWFAAGKRSSCYFSKVFEESIDLIYRLVDAPPITSMNVLEHADLHHLKIRLTEYSKKVNLAGCPQITLATLLLSVLPLSYSMDPTLRKSIKQILISLERRERDQSPIPQGLLPMLSFEAVQEIDISKCPRLHLEAAITCISKSFPSLRTLKAAYLLNFKTTALHQLVHKCPLLREVDLTMDISPLIPAQVSVVSSSLAITSPLSNKSLSVGDDPADVMSLKKSGLSLPNITKLTLEGRSDICDLDLQYISKFCSSLHELNIQGCISVTDVGISNLLRKCFSLEMLDVSNTMVSGAALAQIVHGNPGLKHLRARGCRNMLQQETNTSEGEFSSSYTCKELYLELGKKCKLEEVALGWGFSCFSVEALQPAIKSLRSITVGLGGSLGEDVLQQLSATCPMLESLILHFQVVSDTVVTNMMTSLRNLRVLALCYCFGDISMLSFNFSTPNLRKLRLERVTPWMTNNDLIILTQTCANLVELSLLGCKLLGSDSQQIISHGWPGLTSIHLEECGKVTENGISSLLDCTALEDLLLHHNGPGIQKNFIFYAASKLPMLRKLSLDLCDAREGDFDIPDCDDKCLVSTVKIARCKPRRCNFSLPAHRRPVHEETLVLIRNSKNLYRTVVKERL
The following text describes a protein:
Function:
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The acidic C-terminal domain mediates interaction with histone H3/H4 complexes.
Sequence:
MDFHSVLKMAAAKPGSDGIAKRYSLAVGPPKKDPKVKGVDSAAVQAFLRKKDEESRRKETVEKRKKEDLLAKRKELKHDRKARAMASRTKDNFKGYNGIPIEEKPRKRKRSGTEEDQNDNMAAEGEEYMTEEELYEYSQSESEQEEEEELPPQKVPKPAPGKKPPTPALNFNDLLRLAERKQYEPVEVVRPVKKEERLRTAEELKELEFLERKAQKADRKDPKRNEQLVKVSKGSGDKYSSLKGTHSGNSKSSSTEQNGTIRKSSSDTGSRTEKSGSVFHTKESKKPSSAKDLGGKGSRPNVTGDGKDRHSSSQPSAASNSAFGRPSGSARPSGSSGPGRPLGGSGSSSGKSTGGSASGSARSVGGSGSGSGKPMGGSGSGKPIGGLHSSHGSGKPTGGTGSGSGKPTGASGSGSGKPTGSSGSAKSVRESGSGSRSVRESGSGSRSVRESGSGSGSARSVRESGSGSGSARSVRESGSGSGSARSVRESGSAKQAGGPGSGRALGSGSSFARPSSNSSPAPGKPAAGSGSARPSSSGTPRSSSMGHSTSNSSRQPSSSGAVRPSSGPPTGATPKGPSPRPGAGPTSVRPNSTSVPGSARSSLGSGPGRPVAASATGQLAPAKPKCTVVAETISSKNFVPKSINGHMNGIRTAAPPGHRPAMRPPGPPLPPITSSYKRRIDDDDDYDSEMDDFIDDGGECQDEISKHIREIFGYDRTKYRDESDYALRYMESTFREQQKEEARSLRLGIQEDLEELQREEEELKRKAKQLKAAKKMSR
The following text describes a protein:
Function:
Transcriptional activator of the hca operon for 3-phenylpropionic acid catabolism.
Sequence:
MELRHLRYFVAVAQALNFTRAAEKLHTSQPSLSSQIRDLENCVGVPLLVRDKRKVALTAAGECFLQDALAILEQAENAKLRARKIVQEDRQLTIGFVPSAEVNLLPKVLPMFRLRQPDTLIELVSLITTQQEEKIRRGELDVGLMRHPVYSPEIDYLELFDEPLVVVLPVDHPLAHEKEITAAQLDGVNFVSTDPVYSGSLAPIVKAWFAQENSQPNIVQVATNILVTMNLVGMGLGVTLIPGYMNNFNTGQVVFRPIAGNVPSIALLMAWKKGEMKPALRDFIAIVQERLASVTA
The following text describes a protein:
Function:
Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVSEFQQSSISYPNQNAPVVASSSLPAKLVCGAIAGVIGTCLIFPLDTVKTRLQNQKSGLNGPQYRGILDGARKIITNEGFRGLYRGLIPNLIGICPEKAIKLAMNDYAREFWGRQIKAHPDHLPLFYGMLSGATAGFCQVVATNPMEIVKIQLQLAGASSGTGSNSKITMTGIVRQLGLRGLYKGTTATLARDVPFSFVFFPMVAILKKALTPAHTNGEAPFSVIFSSGIVSGAIASAVVTPMDVVKTRLQVIAKPGDKVYTGMMHCYRDILKNEGCTALFKGVVPRMMIVSPLFAIAVLIYEFQQRYLGKLSQESGFK
The following text describes a protein:
Function:
Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MAVPPAYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANSETSKVSGSLETKYRWVEYGLMFTEKWNTDNTLGTEITLEDQLARGLKLTFDSSFSPNTGKKSAKIKTGYKREHINMGCDMDFDIAGPSIRGALVLGYEGWLAGYQMTFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNEKLETAVNLAWTAGNSNTRFGIAAKYQIDPDASFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFEA
The following text describes a protein:
Function:
Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MTSFRCFLVLSLVSFLLLSTVLPSISTNDEQDDEDLRFLEETEGKSVDIASLPHLSDSDDDQFPDDDEEDEDSGSEQETGASLSDPYKAPQIDDKDVVVLTQGNFSDFIKNNKFGMVEFYAPWCGHCQSLAPEYAAAATELKGEGVLLAKVDATQEDELAEEYDVEAFPTIYFLVDGKHTLYPAARNKDAIVTWIKKQIGPGIYNVTTLDDAERILTSESEVALGYLNSLVGPESDELAATSKLLDDIKFYQTMNPDVAKLFHIDPEVKRPALVLLKKDAEKICHFDGLFVKTAISEFVTSNKLPLVTIFSRESAPSIFESSIKMHLLLFATLNISEKYIPVLQEAAKLFKGKLISIYVQVDNEESGKPVANFFGVSGNGPTIRAYSGDDAKKFAMNGDVTFNNIKAFAEDFLAGRLKPFYKSDPIPETNNEDVKEVVGDNFDEIVLDESKDVLLEIYAPWCGHCRSLEPTYNKLAQHLRGINSLVIAKMDGTTNEHPKAKSAGFPTMLFFPAGKKSFDPMKVNTGRTVVDFYKFLKEHATIPFNLKKAVLVPKDKPTKTSDSKVREKSSSVSSKEEL
The following text describes a protein:
Function:
Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localization to the cell membrane is dependent on TEF3.
Sequence:
MSHFRNHSLAISTSASIHTSASPSPVSPASPASASAGLSRRHSWNVTDESQEIPTFNDPSNASRHVDDNLTPRRAVPLHSTPLGKSGTVHSHRLSERDIIWADVNDGRDIGGDPNETTPTKSHNRPFFDSYQSTTSLHSTISPLDVNGRSSDDRERLTTGPSHVMHYNGIGKGTPRRSPRKPYNESGSSLRRSSTLRNVSQSLRKASVRVVNIMGTERGDGRERLGSDDEGEEVLQDVEIDGDQAFAMSSTNDNPGTVPSPRQLPTRSQREEVDHGRLRGRTMCLFGPMSRVRKSMDRLMRYPWTEPVILLLIITNVVVLAIQSAPALDSPRIDNGYFQGWEDFVLLVLFIVFTLEMFARIVVTGLLLDPETSLRESLFGQDGAVPILKQYLLITKFNIQSNLRRNATKRRAPWRSQGQNDAAHNKDSKTPANSALRSLTGLSEAPFQKAMARQKGLSDQGRPYLRHSWHRIDMIAVFAFWITFFLALTGYEATADRHVYIFRALSVLRAGRLLVITSGTTTILHSLKRAGPMLITVSYFLVFAACIFSIIGVQSFRGSFRRACVLTDPHNSSNVIQLETQCGGWLDPTSFKSMSYLSLDGTSSAVPPKGYICPLGQICMTTDENPNNNVNSFDNVFSSLVQVIIVISINTWAPVMYMAMDSDFFGSSLFFIAGVIVLNFWLINLLIAVVVNTFSDIRAETKRSAFGAGETFLGTEPHWAAEDEKTKNNRLLAFYQKTEIFWVILVVADLVAQGSKSSSSPESMLRLLDRLELAFTLAFDLEIIIRFLAYFPDWRTFFYRKRNCFDLFLAIACSIIQIPAISNSPIYPWLTVFQLIRWYRVILAFPRMKPLLITVFGSFSGLLNMVIFLFLMNFLGALMALQLFRGDLEAGETITFSQTYNSFLGMYQIFSSENWTDIVYDTMGAESQYKQNIIAAIFLCGWFLFSNFIVLQMFIAVINENFAIAEEQKRKQQIQAFIHRAEAPSAHASWIDRLNPYRLMTARHRAVRVKTLPPNLILPLKQNVGIDVSDVPSSLPMNDGKSTKGAVKRLLGRDGDEDQIPLKRFKRPPPRESTDDAEDEDDDRGLTDLLPPLNAAVSTDEHMDAFRERRNQQADFIAAHPSFDKSLWLFKQNNPIRKFCQACVPSAYGERIFGRSTNPTLALIVKTVVFLAVVASIVVAAIASPSYRREYYADHGISRRTWFDLTEVALGLIFVLEAAMKIVADGFIFAPNAYLLSLWNVLDFIILITLLINITTSLIFIGGLSRVTRALKSFRALRLITLFGRLRDTLHAVLFAGALKILDASIFMILYLIPFAVWGLNIFSGLLYYCNDDDSSGLTSCIGEFSTSSIDDSLTYLVPRVWVNPTVDESIWSFDSFRESILILFEIVSLEGWIDVMASVMNIVGRDQQPQNQASQWNAIYLVIFNLFGGVIILTLFVSIIIKNFSTRSGNALLTSEQRQWVDLSKFIKAQTPSQLPKGRPRLPFRAWCYDRAVNKNGFWAVGFTMIYYLHILLLMMEDFSENLLNEVQLDWIFLFLTVLYAVDLLVRFYGLGFKSFKSNGWNIFDLIVITGSFATTIPALQADSSGGTANQANVQLQKLFLVSISLKLVQRISSLNQLFKTSVASLPAIGNLFLLWATIFIFYAILYLEVFGLTKEGNNAGTRFQNYYTFGNALLMLAFMSTGEGWNGYMHDYTIQEPRCTENGNFLESDCGSAPGAYVLFISWNIISMYIFVNMFTGVVVESFAYVYQMPGKSSLNREEMRAFKQLWAEFDSQRIGYIKRKDLIRFFSRLTGVFEVRPFPVEFGVHNIIRHSRPDQVDNNASSQSYVITGVKHAVDVRRVAEQIAQIDYKQVRVRRQLFSRLYNEARISEEPGKGISFTAMLMMLAHYKLIDDESALQLDDLLLRRAKTERVTDLVNLDRVRGLLRTIYWRKRFLATRDARKLTLNAEAEGIPAIVLDPTPITPPDYNGQSRYDTPYSPQVQEKEESIPKRITPTEIIPPTSFSPSARTYPLPASDLSNSSDGNSLPSPSLYNSPTRLTSRPALLGRQPSNNSHLSSDDAHYRRDSRPDEDLHTKDYDDDMLDSMWGDMMREAVDQEGIKNEQG
The following text describes a protein:
Function:
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
Subcellular Localization:
Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Cell projection, neuron projection. Perikaryon.
Domain:
The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity).
Sequence:
MGNSDSQYTLQGSKNHSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSLARSCLSHFKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTENGFHSVGHELADNHITSRDCNGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNGGNPSKVPAEDCSEPVQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKGSSLSSESSWYDSPWGNAGELSEAEGSFLAPGMPDPSLHASFPPGDAKKPFNQSSSLSSLRELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPCRKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDVQGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETSTETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVARRKWKQYWVTLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQLSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPSKLALGRLGILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKEKRPSITQVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPEHRVEDILTLACKMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVCDFGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEALFSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNTANDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSVQSLTSVVSEECFYETESHGKS
The following text describes a protein:
Function:
Orphan nuclear receptor. Involved in regulating fatty acid desaturase genes, acting in concert with nuclear hormone receptor nhr-49.
Subcellular Localization:
Nucleus.
Sequence:
MPTNPNSCEVCSSSSNSSCNHFGARTCKACAAFFRRTVSMKLDYQCIDQPDACRVHCDSRVICRFCRLKKCHDIGMKPLLVKSKNERKNYIRISKGLIRKRSVLGDNVKENSEEIQNDDDPQESDAEMENESTPGPSSEPSENVSAENQETVTKFLKLEASMCDRRRLLYAETPISIVLESGKEWPYENAPLKMFDYKLSQGMSKHDFVMIMDYARGMPGFDEMNYADSVFCYRLVCAVDFVINSAYYTYKRGIEHNELVLSDGTFIPMVPTPLTGYEENANLLFQSQDDLMKFRTLMPLILHQWETCVPFAQLAPSHEEFCLLKAICVWHVSYYRLSEDGRRIAIAQRNRLIRALHHVCHLDSDDVGERFGNVMMALNYIMVNIRHVVSSFVMISFFGIINVDKSMISLTSFWNKSDTSTAPSL
The following text describes a protein:
Function:
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
Sequence:
MQRWICTVCQYVYDPFVGDPLNGVPPGTPFEELPDGWVCPACGVAKNMFVPA
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Subcellular Localization:
Cytoplasm. Late endosome membrane; Peripheral membrane protein.
Sequence:
MLKSSAENKILKLLPNDKPITAIQVIENLDKCPKGFHPISRTYDQDQDADLRESSIFKSSAARYLCVSKSEGLPNFVIQELFVLTEKFNPPRGFSLLNRTADSEQKAWKKKQLCYKLVNLRDTKVAVTDIIVCSRLKKAPEGFKLAGELNGVTVCFKMGNVQDTQNSPDSNGRNITPPVRPAPPYPGNGPIYPSIGADGGDHDYEILKPPGYPSGPSRPAPRPPAPNPRQNSTTGTLGASGGNNLDGVPFIVNPKFLNASTADRFQFPTIRAKTMQQILKEYDYAFTVERQT
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLARYELQSEYRFANPELYKAVPKNDAEALFESITMAALAGIVRQLGEVAELAAEIFNDLHQEVVALSSRGKQIARRVERLEAELPTLEETVYCESDQLSYAFTEGFQWHPTIFVKQNHFSQPELPRFLQQSYDDCREPPRFFLLDNFDVAGAGATLRRYTDPSFFRIKWANSELLKAERLQTGRRVRERGKKRETSGVHDTRQSITPEAKLSFIEASKFIHSVDAFLDPYLADDTDTELRALKVETLRISAKEIEENSLLQKRTRHTTSATDSDFVDGAEHFVDALTSIEPDAEIENEKARCSTSSRTSSGSNQEAAFPVKQEARATPPKDFIQEDLPQRSPFNVQGATELSFYSSTSPSEISSPSASPSLSDLSEESYSSQQIFSVLDSPVVGIGRNATKEREVWTVPFRPSSPSEAASFPDEAPPPPPLPPSKWRVAKTLVPGDVSSSPAPENLKDQGAPVGHQHHDILMDSIVSHDKDTLRKVTSDPRAKSFGSREVLLEQIRSRSFNLKHAAQQEKEKTETPCPATSSVNVATILEKASAIRQESKLERPFQRKKVLLALTQYEDPGLLLLISVAQGVACTKGVFRRIYLDCPTFVSYDQCQNCCTATARCTTGTWCPLFSLTDTLVKCGGVVIVDCCDNCCTIKYTNCALLNKNNRTIVCKGIGFEST
The following text describes a protein:
Function:
Microtubule-severing enzyme that negatively regulates cell migration and wound healing. In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility (By similarity). Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone (By similarity). Contributes to proper cell branching during endothelial and neuronal development.
Subcellular Localization:
Cytoplasm, cell cortex. Note=Localizes at the leading edge of migrating cells.
Sequence:
MLSPIVPYSLLKMHWNPEHAQPLSQWPEQHLDVSSTTSSPAHKSELYSSRGRGSYSYAWANDDISALTASNLLKRYAEKYSGMLDSPYERPSVGAYPEPGAFGGLNGGQKSELEPWPLTHSTDGAYSLVPPSSHESLSGPKVVPTSAGPPGSGNVSAVNSNLSDSGYSGSSSCSGPHSSEYPPSYNGTYLSSGYCPQPSSALPPASLHALQPNPTLLPSYTTTAPVYNYPPSTYPHQTGLAPSYTHPTAPYIPSPLPSRPTVVGGSYGYQNSSVGGSEPGGSLKRKAFEMTLDEEDSDSSRYRKYSYDPMKTGGDSPYGVTDKAGNGFGTGSTDPQGFKPSKPSSQSSLEGDEVGKYSGLKPLVSPTYGAAGDYSPPAAMTGENGGAEQGFSQNRSQKRSDPMKSIEPRMLELVSRELQDCSPAMLWTELAGNCHIKAALEEDLLWPVLRPNPAIHPPKTILLFGPQGGGKTTLARSLSSQIGASFYRLSCATLASKLKGEAEQLLLTLFSVATARQPAMVLLSEVEAIEEEGLRQQLQAQLEKIQHNQSNQFLVVCTTRRPDLIKDSLLRCFSKRYHIGLPDGNTRRHVLLQALAPQGCSLSERELSAVLQRSEGFSVWELLQLCQQALASASASASVPLHSLPASLSSPTLQDFENAFCKVRPHSTPKELDTCMEWSKVYSH