lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.
Sequence:
MASTSLFPSASRKELVKEYVGKSLHEVPCPAVVLDISKLKKNCAAMLETVESLQCGWRAHIKTHKTTELTRLQVGDGTGPVNIVVSTIVEAENIVPLLLEYKNKGRAVNVLYSFPLTSSAVDRLSRVSIALGPNGLSVMIDHPSQLSSVAAIHAKTSIAPLIFIKIDMGGHRAGVIPGTDICSQLIASVISLANRDACILHGLYSHAGHSYSSNSQTVALDYLRQEFEALLITSGEVHSAAGTVFPLTLSVGATPTSSAIRNLLLPSTSSEGSDEISALKATMRAIRDVGCEIEIHAGVYPMLDMQQLATHALPEEILSWSSVAITVLAEITSLYPSRGAAGSPEALITAGSLALGREPCKAYSGWGIVSPWNRDSFALPNTGPEGYSGVKMTRNSPLVKKSVSGLTTHASPEPDMAGI
The following text describes a protein:
Function:
Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (By similarity). At higher calcium levels, calcium-binding to MICU1 induces a conformational change that weakens MCU-MICU1 interactions and moves MICU1 away from the pore, allowing calcium permeation through the MCU channel (By similarity). Also required to protect against manganese toxicity by preventing manganese uptake by MCU (By similarity). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult.
Subcellular Localization:
Mitochondrion intermembrane space. Mitochondrion inner membrane.
Domain:
The EF-hand domains have high affinity for calcium and act as sensors of calcium levels.
Sequence:
MSVLRFLVTRQALAALTRPRTLNIIQNPAQIAYASTLCNQNSNHNAKDLTKSSANLSLMQTRGHKRFGHQEEKTPSVTKYFHMFILSLFLISVMDWGKVKRMLTPKVDADAGQRPSSAADVNGEDKSSESESEDSEDEEAGSDLHLHEGKKIREKVGFRERKIIEYENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMTPGMKQPDGLGLDQYRRYDPKSVGEQLNLHLEKNSIFYKLGSYGLITFSDYIFLLTVLSISRRHFEIAFRMFDLNGDGDVDCEEFEMVATLVRQQTSMGTRHRDHANTGNTFKGVNSALITYFFGPNMDEKLTIEKFLDFQEQLQREILSLEFERKEPNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKRRFRDHGKGISKQDYLDFFHFLNNINDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVFTIFDENNDNQLSNKEFISVMKNRVQRGLEKPKDTGFLKMMRSVFKCAKETKPVLLDI
The following text describes a protein:
Function:
Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristem maintenance. Modulates root, shoot and flower apical meristem maintenance and floral organ development regulation, probably via CLAVATA (CLV)-like pathways involving at least CLV3 and CLE19. In complex with CLV2, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding structure (syncytium) development and ultimately successful nematode infection. CLE14 perception by CLV2/CRN complex triggers root meristem differentiation. Required for the sensing of the root CLE peptides (e.g. CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17, CLE18, CLE20, CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45), which also involves CLV2 and leads to root growth regulation, mostly in the phloem and protophloem. Promotes the accumulation of BAM3, especially at later stages of protophloem development.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Requires CLV2 for export from the endoplasmic reticulum and localization to the plasma membrane.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MKQRRRRNGCSSSNTISLLLLFFLVFFSRTSTSTSCRRRTVKHLSTTSTSSTPLESRITSKVIVISIVSGILTGLVSALVLAFLVRSIVKFMKQTPILKGPVVFSPKITPKSLHAALSNGIQLLGSDLNGKYYKMVLDNGLVVAVKRLGSLEGVGSPESSSSKSVKRRLQKELELLAGLRHRNLMSLRAYVRESDEFSLVYDYMPNGSLEDVMNKVRTKEVELGWEIRLRVAVGIVKGLQYLHFSCETQILHYNLKPTNVMLDSEFEPRLADCGLAKIMPSSHTAVSCYSAPESSQSNRYTDKSDIFSFGMILGVLLTGRDPTHPFCEESASGGSLGQWLKHLQQSGEAREALDKTILGEEVEEDEMLMALRITIICLSDFPADRPSSDELVHMLTQLHSF
The following text describes a protein:
Function:
May act as a cell-binding protein.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MHLQIWWLLFLWDVQTYFAQNYFEERRVGRFRPKALTGTPVEKVTNLSEQDEDCILEMAFLLDSSESAKDYNHNREKKFVLQMVDKLKEVKLNSGRSFSWRMALLQYSSTVLIEQTFRDWKGPENFKSRIAPIAYIGHGTYTSYAITNLTQLYMNEGTHKSVKVALLVTDGVDHPRNPDIFAATSNAKHHDIKLFTVGMTSVAKETSNNAKLRLLASVPATRFVFHMQDPDVVDKILKEVKELVEEGCPQATICSCEKGERGLPGSAGKKGRPGDDGIPGPKGFKGEAGLNGIPGRDGLEGKPGYKGEPGERGECGIPGIKGDRGPEGPIGPRGLRGIQGIQGPPGDQGPEGFQGSKGDRGISGLPGFPGEPGIGLPGHKGDIGVQGRPGPSGPPGIGEPGPAGPQGSQGIPGERGAPGEGLPGPKGDRGFEGPRGPRGQQGPSIKGDKGDFGPPGLPGPIGLPGTGIQGEKGIQGPVGPPGMRGPSGEGLIGSKGEQGLPGESGVPGERGIGEPGAKGEPGSTGLAGLPGLPGEDGAPGQKGEHGLTGLRGPEGSPGIGIQGEKGDQGQRGIRGLTGPPGPSGPSGPKGEPGAPGRLGMPGLPGRAVVGPKGDIGIPGPQGLIGEPGIGIVGPKGDRGSPGPPGPFGPKGDGYPGLTGMPGMPGPPGEPGPEGIGLPGPKGDQGARGPLGLSGPPGEGLLGPKGNVGKTGLPGLQGPPGEGIQGPKGEQGFQGVPGPRGPPGEGLLGPKGDRGASGERGRKGDKGDLGGNGAPGEPGKPGSKGEVGLTREDIIKLIKEICGCGVKCKEIPMELVFVIDSSESVGPENFEIIKDFVTALVDRVTVGRNATRIGLVLYSLEVRLEFGLNRFTTQQDVKQAIRKMMYMGEGTYTGTAIRKATQEGFFGARTGVRKVAIVLTDGQTDKREAVKLDIAVREAHAANIEMYAIGIVNASDATQIDFLRELNLIASDPDSEHMYLIDDFNTLPALESKLVNQFCEDENGALIYNRIGSTINAVAMQKGSHSSTHFVSQINRERYNLYDRQFELEKEKEKIKNIEETHQPQPSPKREEITVIKLEEEEEEEDYDEEESENITGGSDTRGTAISSSTVISSSTQTSSSSQSSSSSSSSQSSSSSKQPISTSKSTSTVILSPSGFSVPIEPSVPKTEFIQDARCALTLDQGPCRTYIIKWYYDKQANSCAQFWYGGCNGNSNRFDAEDECKKTCVFNREGDI
The following text describes a protein:
Function:
Fungal xylanase inhibitor. Possesses competitive inhibiting activity against several fungal endo-1,4-beta-D-xylanases belonging to glycoside hydrolase family 10 (GH10) and family 11 (GH11). May function in plant defense against secreted fungal pathogen xylanases. Is similar to class III chitinases, but does not exhibit chitinase activity.
Subcellular Localization:
Secreted.
Sequence:
MGLVHALLPFAAAAALLLLAAPPPATADDPGLAVYWGRHKEEGSLREACDTGRYTTVIITFYNAFGHGRYSLDISGHPLAAVGADIKHCQSRGITVLLSIGGQGGAYSLPTNASAADVADNLWNAYLGGHRAGVARPFGDDAAVDGIDFFIDQGGADHYDDLARRLDGYNKYYRGRVGVLLTATTRCSYPDHRLEKALATGVFARIHVRMFGDEQCTMSPRYSWEKWAAAFPGSKVYIGLVASPEQDSAWMFQKDLYYEMLQFVRSLPNYGGLAIYDRYFDKKANYTGEG
The following text describes a protein:
Function:
May bind RNA.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAGKSGEEKMKEMEAEMALFEQEVLGAPVAPSPVDPVPLSIQAVPIIRPVIATNTYSQVQQSLQARAAAAASVVGPNFVSPVTFVGPAIPPPRPPVMRPSFIPHALQRPIEPHGAMTRPSFIPHVLQHRAPGPRHPGMPPLQPLMAHHMHGPPPPLMRHIPPPPLGMRPGPPPAPMGPLPPPPRPMVQSAPKINPTVIQAAPTVYTAPPVRKPEEEIVEPPIIPEEKESLSYEETVIGPSMPEIEPVQPEVVLEPVQEDKKKAKPEKLKRCIRTAAGTSWEDQSLLEWEPDDFRIFCGDLGNEVNDDILARAFSRYPSFLRAKVIRDKRTGKTKGYGFVSFKDPNDYVRATREMNGKYVGSRPIKLRKSQWKDRNIDVVRKKQREKKKLGLR
The following text describes a protein:
Function:
Catalyzes the 2-beta-hydroxylation of gibberellins (GA) precursors, rendering them unable to be converted to active GAs. Hydroxylates the C20-GA GA12 and GA53, but is not active on C19-GAs, like GA1, GA4, GA9 and GA20.
Sequence:
MASQPPFKTNFCSIFGSSFPNSTSESNTNTSTIQTSGIKLPVIDLSHLTSGEEVKRKRCVKQMVAAAKEWGFFQIVNHGIPKDVFEMMLLEEKKLFDQPFSVKVRERFSDLSKNSYRWGNPSATSPAQYSVSEAFHIILSEVSRISDDRNNLRTIVETYVQEIARVAQMICEILGKQVNVSSEYFENIFELENSFLRLNKYHPSVFGSEVFGLVPHTDTSFLTILSQDQIGGLELENNGQWISVKPCLEALTVNIGDMFQALSNGVYQSVRHRVISPANIERMSIAFFVCPYLETEIDCFGYPKKYRRFSFREYKEQSEHDVKETGDKVGLSRFLI
The following text describes a protein:
Function:
Inhibitor of the serine/threonine-protein kinase pak4/pak5. Acts by binding pak4/pak5 in a substrate-like manner, inhibiting the protein kinase activity.
Subcellular Localization:
Nucleus.
Domain:
The Inka box (also named iBox or inca box) binds and inhibits PAK4 by binding a substrate-like manner.
Sequence:
MHKSHLDSVAPQLRSDLQCIKASSSSLCDQMECMLRVLQDFKRSSPPPSPDIEKPCVVPPRRAPRRDNRISHRTSDLSEADSACCMDLPSDVSPGSCGQRGLEWDSGYSEVSGGSLRGEEDDIVEEESETSVPTVVLRRLPTPSCQRLSSGGFLNSRQGRIRPKSTSDVCLEQWRGIGLGSDSQDWTGCLLSQSRSRQPLVLGDNSFADLVKQWMDLPENVDEEGRRVRDGGRWLHKPHGFLISLSGNVKRRLGNMSRLRRSEQEAVKRMSCPQLGCRPLSLYYHQSLSDIAEASTNLLHCRSRQPIICNEGAGFL
The following text describes a protein:
Function:
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNESRLLFLWRGGGGRGGGGVGGGGSEREGDGRGSVVIHILPLGLVPAAAPAAPAAPLVELVPLPLLDLLHLVRVAAEGAAELAPGLEGDGDGVAVGGLDLADPQEDAVLVAAHVEEEALGVHRDGGALGQLPVEPPAAAAAAAAAPGAAAQLVLVAAVVVDELGQGVAELDEALRRQGDGLAALQAAGAPAEAAAPAAAAAGPAVDGLADAEEASALVLLEVQVVLAVLPHQELALQRPAGPAAVLGAPARRRRRRRGDLLGAAGPQLRVVLDEVAQVVAELGGHRHGQRQPALRAARAHLGDLQEAALGVLLDVQVPVLLEGVCTPSCPRSEECAVGLSPGRGLEGKTGGLRMNPPPSELLPRGLDSGLTLLMTLLGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDLFIGPKAEEHRGLLALRYPMEHGVVRDWNDMERVWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKNREKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHAIMRVDIAGRDVSRYLRLLLRKEGADFHTSAEFEVVRTIKERTCYLSINPQKDEALETEKAQYTLPDGSTLEVGPARFRAPELLFQPDLVGEESEGLHEVLVFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLSPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARAIHRKTF
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.
Sequence:
MSFRPEYKEYFKQGATARIYNGAFEDAGFYDEVDIKEFEYSREEKTFYYPCPCGDRFEISLEDLRNGEVVARCPSCSLIVCTVYEAEDLEKYL
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDVGLGQNTTSDEIKVGVVLDLKTNFSKICLTSINMSLSDFYQTHPHYHTRLALHIRDSMEDIVEASVAAYDLIKKEQVSAIIGPRSSMQAEFMIKVANKFQVPTITFSATSPLLKSIDNPYFVRATIDDSFQVEAIAAIVKSFGWRSVVAIYADNEIGKEIMHSLSDALEDVEVQRSAISQEASDNQILKELYKLKTEQTRVFVINIDSSLGFRFLKKAREIGMMEEGYVWLLSNGMTHMMRDNGRSLETMQGLLGVRSYVPQSKEREDFSLRWKRKFNKENSAGDGTEPNVFALWAYDSVTALAMAVEKTNTKTYIKTYGPHLIEALSDIEFKGVAGEFKLINRQLESSTFEIINVVGDEERIIGSWTPSSGLVNAQSNKTTLLLGKRFLPVIWPGNSTVFPKGWEIPTSGKKIKVGVPVKKGFLNFVEIKTDPISKVTTTTGYAIDIFEAALKKLPYSVIPQYYGYESPENNYNHLVQQLYEGKWDAVVGDITITANRSLYVDFTLPYSESGVSMVVPLRDNKNKNAWVFLQPWSLDLWVTTGCFFVVIGFVVWLFEHRVNTDFRGPPHHQIGTSFWFSFSTMNFAHREKVVSNLARFVVVVWCFVVLVLTQSYTANLTSFLTVQRLQPSATNVEDLIRNGESVGYQHGTFVRDFLRNLNFSETQLKSFASAEECDDLLSKGTGKGGIAAAFDEVAYLKDIVSHNCSKYAMVEPSFKTTAGFGFAFPKNSPMTKDVSIAILNVTQGKEMRRIENKWFNRVTSECPDPNSDDLSSNRLSVSSFWGLFLIAGVASFLALLVFVALFLYEHRHTLCSNSEGSIWRKLKSLFRIFDEKDTRSHIFKSSAVHNASSPITPCTPSPSNVQIRPLPRSMSLNREFELRRACFSMSEERFRTQPKHDKQGESDIEFGAESQREVKQTQ
The following text describes a protein:
Function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
LQRHETMAPSYFLAFPKYLEEETRAISQAAEKMEASIQDRKEKFHSKYKRSLPPTGLLSTDVLMMLSNVSGCLRYMLPPKCLENCMTSKYRHITGACNNRDHPRWGASNTALARWLPPVYEDGLSQPKGWNPGFLHNGFPLPPVREVTRTIIEVSNEAVTEDEQYSDMLTVWGQYIDHDLAFTPQSINRPSILGQADCSMTCENRNPCFPIQVFVNDTLSIMDCLPFYRSSPACTTGLQGVLIGNLSILNPRQQINGLTSFLDASTVYGSTTAAENKLRNLTSQEGLLRINVKYFDHGREYLPFVNQVPSACAQDPKTDNGERIECFMAGDTRSSEVISLTAVHTLWLREHNRLAKELKKWNMHWSPEIIYQEARKIVGALHQIITMREYVPKIIGPEAFNQYIGPYKGYDPKIDPTVSNIFSTAAFRFAHAAIHPTIKRLNAHYQHDPSLPNLNLHEVFFAPWRLINEGGLDPLLRGTLATAAKLPLQNQLVNEELTKKLFVLSNNGSLDLASLDLQRGRDHGLPGFNDWRTFCDLPILKTESELTEAIQNKKVVQNILELYGSPDNIDVWLGGIVENFLLDARTGPLFACIIGKQMKALRDGDRFWWENDDVFTEAQRCELRKYSLSRLICDNTGITEIPHDAFKLGKYPKDFEPCENIPSINLEAWQETPQPELACGFPKGIEHGDYVYCSKAEKSMVTYSCHQGYKLLGEEQLSCTNETWNSKPPICQDINECENKDNPPCHSSAKCVNLKGTFQCLCTDPYELAEDGKSCKDSGKLSKGSLVSIILGIILISFLALLSWLVVCWW
The following text describes a protein:
Function:
Stimulates viral immediate-early (IE) transcription. Plays a role in the inhibition of the host innate repsonse by targeting STING1 and thus the cGAS-STING pathway. Also counteracts host DAXX-mediated repression of viral transcription. Displaces a DAXX-binding protein, ATRX, from nuclear domain 10 sites (ND10) shortly after infection. Increases the basal level of SUMOylated DAXX in infected cells. Stimulates quiescent cells to re-enter the cell cycle, proceed through G1 and enter the S phase. Interacts with hypophosphorylated forms of RB1 and induces their degradation by the proteasome without involving ubiquitin conjugation.
Subcellular Localization:
Virion tegument. Host nucleus. Host endoplasmic reticulum. Note=Present in the nucleus shortly after infection as well as during the late phase of viral morphogenesis. Detected at nuclear domain 10 (ND10).
Sequence:
MSQASSSPGEGPSSEAAAISEAEAASGSFGRLHCQVLRLITNVEGGSLEAGRLRLLDLRTNIEVSRPSVLCCFQENKSPHDTVDLTDLNIKGRCVVGEQDRLLVDLNNFGPRRLTPGSENNTVSVLAFALPLDRVPVSGLHLFQSQRRGGEENRPRMEARAIIRRTAHHWAVRLTVTPNWRRRTDSSLEAGQIFVSQFAFRAGAIPLTLVDALEQLACSDPNTYIHKTETDERGQWIMLFLHHDSPHPPTSVFLHFSVYTHRAEVVARHNPYPHLRRLPDNGFQLLIPKSFTLTRIHPEYIVQIQNAFETNQTHDTIFFPENIPGVSIEAGPLPDRVRITLRVTLTGDQAVHLEHRQPLGRIHFFRRGFWTLTPGKPDKIKRPQVQLRAGLFPRSNVMRGAVSEFLPQSPGLPPTEEEEEEEEEDDEDDLSSTPTPTPLSEAMFAGFEEASGDEDSDTQAGLSPALILTGQRRRSGNNGALTLVIPSWHVFASLDDLVPLTVSVQHAALRPTSYLRSDMDGDVRTAADISSTLRSVPAPRPSPISTASTSSTPRSRPRI
The following text describes a protein:
Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
Sequence:
MWPHLLHLPEEILLLLFSYLDAQALGRLAQVCRKLQHFTSKDAVWRKIAKKCLNSGFVQQGTDVASWIPVKERVRVSQNWKNGRCRRNILLKWKRNLMPWIHLDGNILYLSQAEKITAHKLCSNSNGVHRQPFAVFLNHREDVCRFVLNNSHIISGGGDGRIAIHKVHSAFSIHFTAHDQDVNCVDCHRGIIVSGSRDRTAKVWSISPSRAGHCLHTIQTDDRVWSVAINPTLSSFITGTACCGHTSPLRIWDLQSSFITGTACCGHTSPLRIWDLQSGQLMTCLGTDFRRGAGVLDVRYETPYTLLSCGYDTFIRYWDLRTSTRRCVKEWEEPHDSALYCMQSDGNHMIVSGSAYYGVVRLWDKRMNQCLQSFSLSSPTSSPVYCLQFNTRHLYAALASALHLLDFTSGESLFRAL
The following text describes a protein:
Function:
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). In vitro reconstitution experiments this subunit is dispensible.
Sequence:
MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISHKYVGKALEEIDAGLLSFEKEDRE
The following text describes a protein:
Function:
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.
Subcellular Localization:
Lysosome.
Sequence:
MRVLLSLVVILFIINSAFAVKINIGRPTKSHKTIHHETWVEEQTDQFDNIKVGQLLGFKRSPNRPKLQIKSYDPLGVQIPTSFNAQTNWPNCTTISQIQNQARCGSCWAFGATESATDRLCIHNNENVQLSFMDMVTCDETDNGCEGGDAFSAWNWLRKQGAVSEECLPYTIPTCPPAQQPCLNFVNTPSCTKECQSNSSLIYSQDKHKMAKIYSFDSDEAIMQEIVTNGPVEACFTVFEDFLAYKSGVYVHTTGKDLGGHCVKLVGFGTLNGVDYYAANNQWTTSWGDNGTFLIKRGDCGISDDVVAGLP
The following text describes a protein:
Function:
Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.
Sequence:
MSETQAQGVQSPGQVASTSYQPRPARKQVTQAKFDAIREAFSARPDSAGTFNIWYENFAGVDREENEAQKAKRETRCDIARDSGYTRADITLKTQAARIQQGAPVAPDEAVYCCIHFARGCCPHGAECNFLHRLPRPNDYPSQGRDCFGREKLGNYKDDMSGTGSLSKVNRTLYVGRIHEEHGVSSPSAPANSAWRDGGKTLKGGRSIHDVRNKNGPRPRQDPKSYRPQHNSVRPETDNATERVVRRHFSEWGEIDRLRVLTGRSCAFVTFKYEANAQFAKEAMLNQSLDHNEIINVRWASDDPNPAAQKRNQEQMRRAGERAIMAGMSEQAIQAQQALRALEGLEHQRGEDADSKRRRISHQSYDEDMRRLEEENERGWVEFAQERQAAVAAAPTSQAPSAASSASKNNITGSLLNSETMSHLASLQNLDQKQGGASDTYPPPVSSNGLGSLAGYGSDSEDDDS
The following text describes a protein:
Function:
Protein phosphatase.
Miscellaneous:
MISCELLANEOUS: Present with 2310 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSYSITNVKYLDPTELHRWMQEGHTTTLREPFQVVDVRGSDYMGGHIKDGWHYAYSRLKQDPEYLRELKHRLLEKQADGRGALNVIFHCMLSQQRGPSAAMLLLRSLDTAELSRCRLWVLRGGFSRWQSVYGDDESVTAGYLPDLWR
The following text describes a protein:
Function:
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Sequence:
MKNLFACQHLALSAIQHAKGGHVGMALGASPILYTLWTKHIQFNPNCPKWINRDRLVMSAGHGSMALYPILHFAGLITKQEMLHHKYGQVNTSSHPEYAPNNFIDASTGPLGQGLGMAVGMALTQRVLAAEFKALSPKLFDHFTYVVVGDGDLQEGVSYEVAHLAGVYQLNKLIVLHDSNRVQMDSVVRDVSLENLQTRFTNMGWNYLETSDAVADIDAAIKQAKKSDKPTFIEVHTTIAKNTTLEDQPAGHWFIPTDKDFARFNSNTKTNFTPFEYPQTVYDFFHKQVIARQAKPVQAYKELLEKLKDKPLYTKFINWTENDYQALYLNQLDERKVAQANAATRNYLKDFLGQINNSNSNLYCLNADVARSCNIKLGDDNLHTNPHSRNIQVGIREFGMSTIMNGMALHGGVKVMGGTFLAFADYSKPAIRLGALMNLPTFYVYTHDSYQVGGDGPTHQPYDQLPMLRAIENVQVWRPCDEKETAAGVNYGLLSQDQTNVLILTRQALPSLEQSDSVQTLKGGYIISNRKQPDVIVAASGSEVQLALQLEQALNEQQLKTRVVSVPNINMLLSQPQSYLQQLFDPNSVLLTLEASASMEWYALAKYVKKHTHLGAFSFGESNDGQVVYEHKGFNVTNLLKLIKTLKS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
LIVVMAAKRKRDTVDDEGEIAKFNVPAHIKSQEKRLIVVLENANLESIKVGKAFELLNCDDHIQQMRKFKKDPAFCRPDITHQCLLMLFDSPLNRAGLLQVYIHTEKNVLIEINPQTRIPRTFKRFSGLMVQLLHKLCIRAGSGSVKLLKVIKNPVTDWLPVGCKKVMMSLHAEKLVRPRDLVPETNEPITVVIGAMAHGSVSPDYVEDSFSISQYPLSAALTCSKLCSAFEEAWGVH
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MSDSLTAIKALLGSDNFSDKVRGLNQLRALEPAEAFPLLKPLVNDANPRIRYAAVSQLDPVGKADLEQSLQLLRDRLFNDPEIDVQSVAADVIGGLKLTAAYPDLQKAYEETPEWLLQMSIVATLGEMGDRRGFDLLKIALDSENSLIRTAAISALGELGNPEALPLLASLVQDEDWQVRYRLALAVGHLEHPDRQSLLQQLAQDQVEQVANTAQELLTA
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface.
Domain:
The proline-knot motif may be involved in the targeting to oil bodies.
Sequence:
MAEHYGQQQQTRAPHLQLQPRAQRVVKAATAVTAGGSLLVLSGLTLAGTVIALTIATPLLVIFSPVLVPAVITIFLLGAGFLASGGFGVAALSVLSWIYRYLTGKHPPGADQLESAKTKLASKAREMKDRAEQFSQQPVAGSQTS
The following text describes a protein:
Function:
Component of the intraflagellar transport complex B (IFT-B) involved in flagellar assembly (Probable).
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to the cytoplasmic and membrane-bound portions of each of the eight axonemes, localizing particularly at the flagellar pores and at the distal flagellar tips. Localizes to the basal bodies.
Sequence:
MITIETELINSTIDALKELISRPPLTEKLLSRPPFKYILDICKAVSAATGFPSPESCNYDDITDREERTAFLTSIIGQITDQLGVPVDVQIKSILAGKDVPKTLRMLVMLAQAAKLFKVRSNSSQPPPQQAPRETVASPPQEDLEALAREKAEKERQRREQEQQERERKERERQEKEREEREKHELESRERAEAEQWKQKQQQQQQQQQSAISPQKSPPKVRFADDDKTRVEEHQPVIERPHFNRPPPSQHSRRMAVTATSEPSAPQPSAMRLVKVVREESSDESNQDLNQNAGQDGGFTMGLDAEWCDEMLPGEFPLDTGAPAPSSTHGELVANILDTAEAYNVALHGDGSKKPTGLSTQRDKKPIDSYSQPVQKLISHISAIIRKSVPYAKHTAFLDEHILTMRTELHTASEAVTKLLSTSLKQESSLKQANNACESKLHSLKEQIYSLRQAQLELLHSTLAL
The following text describes a protein:
Function:
Required for the initiation of sporulation and for normal chromosome segregation. Antagonizes sporulation inhibition by Soj. It probably interacts with a specific DNA site and other proteins involved in partitioning and cell division, and antagonizes Soj in response to cell cycle events related to chromosome partitioning.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDDEALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEALMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLTLPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQNVPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILELLSERES
The following text describes a protein:
Function:
May be required for microtubule anchoring at the centrosome. Required for ciliogenesis (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cell projection, cilium membrane.
Sequence:
MYEPGTEQINCNGRLIELPTLEVVRPAPKMPSDANIDWLLHIYFTRREFTRCRRLIERELNRHLNPEYLYFVQGLIDREEGNHIEALRHLQKSAELNPRNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEIYHYLGELLYRAATTQSQKDVASQQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQYQKAIEILENCLHLTPENSEVLIEISVLYLKINETQKAHDRLAEVVSIERKCSPKGLLAFGAILQSRNDIDGALSKYSQIANAEPEIAELWNNIGLCFFKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAECYMLLGLCLRKLDDMENAFVALERASSMATGQQGAGRNPLVVLNFALFCYETGRLALSTEQYNRFMSQAQDLLLPTEYKFQATKLKSLLRISNQGNGILLDSADMGESDLGHNRATELLPDELPLEVNAVVSQN
The following text describes a protein:
Function:
May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.
Sequence:
MATVEVATELGTVVTAVGPKAKDEEEEEDEEESLPPCETVRWAPVGAVAEAGPGAATFSEEAAAEEPGAAPGSPPDATVRTLRRLQAERRQLDSALLALSSHFAQVQFRLRQVVRGAPAEQQRLLRELEDFAFRGCPHVLGYEGLEDPCDSEESDVLPGDRPRVRGEVQSEQEKRERLETQREKQKELILQLKTQLDDLETFAYQEGSYDSLPQSVVLERQRVIIDELIKKLDMNLNEDISSLSTEELRQRVDAAVAQIVNPARVKEQLVEQLKTQIRDLEMFISFIQDEVGSPLQTGGHCECKTSGKAGISSTRAGSSTLPPGPDKAAKAEDTKWVRETGLHLMRRALAVFQIFAVSQLGCATGQIPQTLWQRGQADRDYSPLLKRLELSVDRVKQLALRHQPHDHVITSANLQDLSLGGRDELTMAVRKELTVAVRDLLAHGLYASSSGMSLVMAPIACLLPAFSSAPETMHPWELFVKYYHAKNGRAYVESPARKLSQSFALPIMGDAAVTPKQSLLTAIHLVLTEHDPFKRSADSELKALVCMALNEQRLVSWVNLICKSGSLIEPHYQPWSYMAHTGFESALNLLSRLSSLKFSLPVDLAVRQLKNIKDAF