lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway. May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).
Sequence:
MPLKFCMERGFQSHPVRGCLVGASRFLSCIKFLVSINPESKSRATNREVLNELIKLHGKTSLGGKLPAYDGRKSLYTAGSLPFESEEFVVKLIDPEKKDKERAEREYKITIRIAGRTDFYHLQQFLLGRQRDMPQETIQFGHRGDIGEGLECWRGYYQSLRPTQMGLSLNIDISATSFFKPVTVIQFVEEFLNIRDTSRPLSDRDRVKIKKALRGVRIETNHQEDQIRRYKITGITPIPMSQLIFPVDDNGTRKTVVQYFWDRYNYRLKYASWPCLQSGSDSRPVYLPMEVCKIVEGQRYSKKLNNKQVTNILRATCQRPQQREQRIHEMVLHNKYTDDRFAQEFGIKVCNDLVSVPARVLPPPMLKYHDSGREKTCAPSVGQWNMINKKMINGGTVDNWTCLSFSRMRPEEVQRFCGDLIQMCNATGMSFNPRPVVDVRSSNPNNIENALRDVHSRTSELLAREGKGGLQLLIVILLEVSGSYGKIKRVCENDLGIVSQCCLPRHASRPNKQYLENVALKINVKKSQQSSLVLMSHTPPGEDSASSIAAVVASMDWPEITKYRGLVSAQSHRQEIIEDLFSVGKDPVKVVNGGMIREFLIAFRKKTGRRPERIIFYRDGVSEGQFSRVLLHEMDAIRKACASLEEGYLPPVTFVVVQKRHHTRLFPEVHGRRDMTDKSGNILPGTVKDRQICHPTEFYFYLCSHAGIQGTSRPTHYHVLYDENHFTADELQTLTNNLCYIYARCTHAVSVVPPAYYSHLAASHAHCCIKGHSSGSGSTPGNEHDIVKNSAPTLQILVKVLDFQIVPLTMKLKSSAEDIVALALSKHRVSLHDVYVYHGRRVIAKSLTLESLKADRDSTFLIMPRMRGGCNDTIGGFKCIPLEQHIRSLGDSLFEIIWIPPDLRVSGFCSYLIILGKPARKIICQLLKLLEIIHAANRFASRFTIADLVFLPDLGCIAFKKGVKIRWNLRREEYKLNMGDVASIISCWFRFNRRKLEALEAGIHELRPGQGDSPMFVDILVKDLRSPTHETGLSANYRGFYKNCSALRSCSAHMNLFTSLDIRKDFMVGSADWGNFVKALGDIKLPGWYRTAMRSPEMRKVLFFEFNDPHTGELRGKRYRALSVFSWLEFARIFIKHMKKGLCTDKQATALLCVIFSNIVPVVEKKLTYSYRPPAKEKSNESFTVEEILDPS
The following text describes a protein:
Function:
Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin.
Sequence:
MLNVLFFAQTRELIGVDAIQLEDDFATAEAVREHLAQKGDKWALALEKGKLLVAINQTLMPLESAVKNGDEIAFFPPVTGG
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence:
MSPSVSSPQLRHTKSNRAISRIDRTDPLALALQPPANEAPADKYARLHQEKLAKQRSDEIDKFLKQHQEDRATHGLASSPSTSVDGANFKKGRVYKMVLLGQAGAGKTTVLKQMRLLYDPPAHERERRGWTKIVLLNLTSSVRVLLETLSLYHDQRLERKSSELSRLESSTSASTSTSASASSPKHVDTESQPNDATRLELAKQLGTTKKINTSSLPWLTHIPSVVQLERALRTELGAFGEEAVLSASSDEAAITNQKVRTRLDAQGSSSIRGEKSPLVLRPGWQERLFTYARRSLSLTQNGRAAAARRETDGGDSQSESEKDNSETLKLLRAIRPEVLALWNDDAGCRALRKRGLFLDGQSDAATSYFLDNYSRITDAAYRPTDEDILHSRVRTLGVTEDVFRVDRSLIYRIYDVGGSRSQRAAWAPFLDDIESIIFLAPLSAFDQPLVEDCSTNRLADTFTLFNQIVTNPLLEHATMILFLNKIDLLEKKLRQGVQLHKYWPEYVGDNDFEAVWRWFRAKFRDALRRAEDEVNLDQTSRRRLYVHTTVATSTVQIRAILMSVKDSILRENLKLTGLVG
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLTSPKYYSPGDPLLLRQGGEKGDIGELDTLRHNVSQSSFAELLKYAPNAPPQAGRVDYDGIMASVLPPRGLSTKEELADMPREKAADKVIPTYEQPPKRPQRNLQHGDPRFIGKINQLEVQRNYAFIGELRREELKECDAQYRALSEDTPEEKREALRMKLLKLKRQVGEMERRKAEEDIREKLVKAELRAIVQGKRPDFIKDRDIKRLTSESLYCASAGTRKGDRRLQKARRRQRLLTL
The following text describes a protein:
Function:
Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.
Sequence:
MSVPLAPKKSCFGQLRDHREGAKNNNESILRTGDTNANQIMLEVSSSCDEAKSRDLDDELGNSNLSRPQYHSHFQKEPLHLQGFGKGSQAGSTSQRESQASLTVHRQLSEEHAVKRGALQAPQCVQGPSLSSWRNAVGQASPEASAKKDAEIPRHIPKDKLAKTLDNEELKRASSCSAAAGSVPPTDLQPVQLDTLGPQDHVPARGEGPQRTPASHSPGKGFSPGEGTSEGNSVYLPKPSTSEAKGSSPSDTKMEGPHGLDVYNERITHAELTPSSASASKENPGLRHPEVCLGQGTGKSKVELKSVQPRNEEGLTSAQAQGPGCHEERSMSPVERQELLEKAYREATSQGNSSHRQLGVRRGSSLEEMTGVSAGVEGSQQATPTLSAAPAGEAGTRLTGKMSAGVGRMARETASGQTAPDVGQAAPVRRDPTESVPSEVSGEERRLGSGNSGSTKLLASGPSAGGSRTDTSGLLSPRGSNLEARKGKEMVAENRNLLENAAQTDNTPAGVDSAFSTPAPLLHPETTVNSSHHPTPPGSSSQELGVFSGDTGSPSVASPPTDGGQVLNTSPKVPDRTTCSSGIPKPPTHPKDTPSSQEAREKLETEKMEERAEAKPILMPKPKHVRPKIITYIRRNPQALSQGDASLVPVGLPYAPPTCGMPLPQEEKAASRDLQPSANMYEKLKPDLQKPRVFPSGLMVSGIKPPAHHFSQMSEKFLQEVADHPGKEEFCSPPYTHYEVPPTFYRSAMLLKPQLGLGAMSRLPSTKSRILIASQRSSASAIHPPGSLTTAASFYGSDPSDLKKASNSNAAKASLPKSGLRPPGYSRLPAAKLAAFGFVRSSSISAVPSSQSLDSVQPEQSRPVTRSTFGNEEQAPLKQALPSKDTPKGAGRAAPASSSNATTPRRSLLPAPKSTSTPAGAKKELQKDPEAKKPAVSSPKRTASAATKPHSPGYPKQRTSAPRNEFPPKPDLQAREAERQLAQRLRDRCEWQARQLGLARRELKKAIQGFDALAVSTKHFFGKSERALAKEKELSIELANIRDEVAFNTAKCEKLQKEKETLERRFEEELRRLGWQQQAEVQELQERLQQQFQAESARLQAEHQDQLLRMRCQHQEQVEDITASHEAALLEMENNHTVAITILQDDHDHKVQELMSTHEFEKKELEENFEKLRLTLQDQVDTLTFQSQSLRDRARRFEEALRKTTEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKNIILEERIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR
The following text describes a protein:
Function:
May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular Localization:
Nucleus.
Sequence:
MARPRKRQRPVRAPGIGDDLQTTTHEENAPGREEGIVEKTEEDEVNNKKKKSEKGKKMGTHKVDGKGKEEENSEKVERSSSFVANQVVETGNDQVVFEFTESLNKRLRSAVGGRRVNYCSQDQGFEEEGDEVFSRRKRKKGKRQKRKLSKLKAEEEEEEKEKEDDNDKEVIDKEKDGESDRKGWKRRNEPKNEEKEAMVETRRYPARASKAPKRMGEFVSDNTAKKKTLSKDSIMCHQCQRNDKGRVVNCKSCKRKRYCIPCITNWYPKMSEEEIADVCPVCRDNCNCKACLRMDGPVNKLKEALEMKFSGDEKLRHSKYLLRALLPHVKKFSEQQMMEKVMEARIQGSSPSEIKLKQAVCHPAERVYCNNCKTSIVDFHRTCPLCNYDLCLICCQEIREGHLQGGEKEVTVQYVNRGFEYLHGELDSSMLTEMVEPLDSPTKTNCKELEGVESRWKANGNGSIPCPHKEMGGCAEGLLELRCMFKENAVLKLVENAERIARDLNVEDMPETTNHQCPCYSSMAEVDLGDCKLRKAASRKDSNDNYLYCPSAKDIHNGDLNHFQRHWAKGEPVIISQVFENASGVSWEPMVMWRAFRQITNSKHGQHLDVTAIDCLDWCEAQINIHQFFKGYTDGRFDSKEWPQILKLKDWPPSNKFEERLPRHHAEFHYCLPFKEYTHSQSGLLNLATKLPEGSLKPDMGPKTYIAYGVAQELGRGDSVTKLHCDMSDAVNVLTHTAEVKLKPEKLAKIETLKQEHCSQDQKEIFGMAKVDQEIYMGNGGLHKICGNKFEELQANEAGAVWDIFRRQDVPKLKDYLKKHFKEFRHIYCCPVPQVVDPIHDQTLFLTLEHKKKLKEEYGIEPWTFIQKLGEAVFIPAGCPHQVRNIKSCIKVALDFVSPENTGECVRLAEEFRLLPQGHRAKEDKLEVRKMILHAMCETVNYLDPQAKNMLDDGSTSLWSHSWMQLG
The following text describes a protein:
Function:
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Major; MISCELLANEOUS: [Isoform 4]: Minor.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQTV
The following text describes a protein:
Function:
ADP-riboxanase effector that inhibits host cell programmed cell death. Acts by mediating arginine ADP-riboxanation of host caspases (CASP3, CASP7, CASP8 and CASP9), blocking their processing and activation. ADP-riboxanation of host apoptotic caspases (CASP3, CASP7, CASP8 and CASP9) prevents their activation, thereby inhibiting host cell apoptosis. ADP-riboxanation of host CASP8 also inhibits host cell necroptosis. ADP-riboxanation of host CASP3 also abolishes pyroptosis by preventing its ability to cleave GSDME. May also able to inactivate CASP4/CASP11, blocking inhibiting LPS-induced pyroptosis; however this activity is unsure in vivo. ADP-riboxanation takes place in several steps: CopC first binds host caspases and NAD(+); NAD(+) is hydrolyzed to nicotinamide and ADP-D-ribose. CopC then transfers the ADP-D-ribose to the modified arginine of caspases and forms the ADP-D-ribose-deacylization on arginine, leading to deamination to remove one N-omega group on target arginine.
Subcellular Localization:
Secreted. Host cytoplasm. Note=Secreted via the type III secretion system (T3SS).
Domain:
The ANK repeats at the N-terminus recognize and bind host caspases (CASP3, CASP7, CASP8 and CASP9).
Sequence:
MRVENHSPSLSKLNPPEAGSGDPTAIGRRLSGIRRAPLPHVSAGSDGEAAAAGKIGAFLRKAVAAQSYGLMFANGKLFEATGDALEKRGQYGFSALQRLDGLSRRNLAAVEARLGALDSAERGLKERIMTGAWHFRHQSNAALDDGKTAAIASNHLLARESRSSGGNTFAGDKALLSNHDFVFFGVEFSGRGKQDKPLNHKHSTMDFGANAYVVPDTLPACRHGYLTLTDHFFNRVPGGREAEHQDFVGSFPQMGAETGRWIHEGKYRQNAPIFNYRDMKAAVALHLIEFLRDSKDAAFKAYVFDQAMQSGQALDRVLNSVFQAEFHIPRLMATTDYAKHPLRPMLLKEAVDSVNLPALSGLVSSKGDAVTAMWHAIDKGKDAVAAHLLGNWRFEAGDFASAPPGFYHELNYALSEHGASVYILDQFLSRGWAAVNAPFEHVNSGETMLDNAVKYGNREMAAALIKHGADRNLLSEWNGGKLDALLA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Note=Associated with ribosomal chromatin, even in the absence of transcription.
Sequence:
MSTARPRIITSKAPLLPQQTTPEQRYWRQYTSAQLVKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNNFKVWDLTSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSNNFQRMMRGSEYQGDQEHIIHNDKVRSQRRMRAFERNINQFKWSEALDNAFVPGMAKELTLTVLQELRKRGKVRVALYGRDESTLEPLLNWCLKGIEDVRSASIVADWVAVVLELYGNTLESSPVLQELMIDLKTKVRHEIHKSKEAQRIEGMLQLLTS
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.
Subcellular Localization:
Cytoplasm, cytosol. Early endosome membrane.
Sequence:
MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVAAELDSLDGRKEPQRCTLLVSQFRSCQDNVLNIINQIMEECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGTLRDQALRDLNTYTEKMREALRRFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALEFGYLTQDMIDDYEPALMFTIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQALTEEELHTLERSLCVSQDVELPIRADAQAPSALAPSFSASLAPEETLSASANNPEEELACSMQYDDQELEELSRMVHRAGDEMSSLLSPPSACQSPAHRAGSEASPRGEASPARAQLKSGSDEEERVFFMDDVEVTESPARPESPRSTFELTQGNVQQRGQDGQSGEVGVRAPALVKEEDWSNNNIEGDKIKLASLAGSTSCSCLDSQLYLDGWEVSAEDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAAASQEVPGHSISPLEPRAEGTGDNTHKLSTTATNCLLHSCVCCGSCGDSREDAVECLREKCGPGSVLSASNPSVSLAKGGEKEPERLEEAQPSDVTLPAEDASSRQEPKAPASNKCLAHTSGPQVDTASRLQGESEVKGQPEPEARKQDSEKSPVVSGDSPRGDTAQTEPQHLSGSRAGDRTQGLALPSSTTGSCSLDSTRLEVTTAVMPVTPMATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLKKVTQSLRSAALEDCALCQETVSSSELAAKTRDGDFEDPPEWVPDEACGVCTSCKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKTGM
The following text describes a protein:
Function:
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MASIIHEKLVEAIKELDRSGNTLPPPNKELIEQIKEELTGFKESQILNPRMVYANALRQRLKDLYEIYLSERLKRIENIRWEIGTALPVNIRASMTNDEIQYFKQYCKIVGEYGVNSEVDVVSDTLYPPINNYINVRANVTKGMDDLPQNPSIYTTNGLLKLDNSEVQCVLRNSTVDSLIHLGVLSIVD
The following text describes a protein:
Function:
Plays a role in cell wall stability and rigidity. Required for normal adhesion to host cells and for adherence during biofilm formation. Necessary for proper oxidative stress response.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNFNKFLIIISCYLACVFALANQNDGGDDDSKTKKTTTWVWVTTTIGGQLATISTAYSQKFISTHSSEDAKSVASGEIGLGSLSGSVGGIKTYSQTTITNANIAPSNNNVFLGIESLYTGIVGGIVLILGLL
The following text describes a protein:
Function:
May act as a catecholamine-responsive trans-membrane electron transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
DOMON domain could bind catecholamines and thereby could regulate the cytochrome b561 domain function. DOMON domain could bind one heme b.
Sequence:
MDRTQSPKTALFAVLATLLVLTVNGQSLCNTHRFTNNLAFADCSDLSALGSFLHWTYNEQNGTVSIAYRHPGTSASSWVAWGLNPSSTQMVGTQALVAFTNTTTNQFQAYTSSVSSYGTRLERSSLSFGVSGLSATLVSGEVTIFATLELSPNLITANQLWQVGPVVNGVPASHQTSGDNMRSSGRIDFRTGQASAGGGGSGDRLRKRNTHGVLNAVSWGVLMPMGAMMARYMKVFADPTWFYLHIAFQVSGYVIGVAGWATGIKLGNDSPGTSYSTHRNLGIALFTFATLQVFALLVRPKPDHKYRTYWNVYHHTVGYTTIILSIVNIFKGFDILDPEDKWRWAYIGILIFLGACVLILEPLTWFIVLRRKSRGGNTVAAPTSSKYSNGVNGTTTTGPHHQDA
The following text describes a protein:
Function:
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MLSTNISSNLNNTLVNITGRENKGEWLLYPQSNYEFNIDEKLKNKFIIDKEKCKKRINAYNKNGIRNSVLAIILCHRYEYPHLLLLQHIESQKYYLLNGKYKTWEKPKEVLKKKLQKYINKIKDIHFTPAQINKEQEETVEIGDFLGEWWRTQFNSVFLPYLPAHISRPKEYIRLYQVILSPKCIFHLPPGFTLKAIPLFDLNNCGLAISGLSSILSRFKLHCMVQEQDAEN
The following text describes a protein:
Function:
Plays a role in inducing apoptosis and is involved in the repair of head patterning defects in the embryo caused by extra maternal copies of the homeotic gene bicoid.
Sequence:
MEHHQIYRHKKFDMGRKIEKCDLQLKEELISRSGTPCTSRSPFDAANQSVSLGFSDQDADFPPLPKRRRLGSSSSSVSYQSASPIITEAIQDIFKYHVNMVRKFPKKERSPKDQERRNKNTIACRMSRRKKKFDDLQIEQQYKECSDEHLKIAEQSLRARVYLNHLKQLVKQEDHPLVSSRRVPEENTKSNFSIDYLIGGIKQEHA
The following text describes a protein:
Function:
As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MASPLTVGFCERATSAEDVSECFDSVVQVLNVKKIASTDTTAVDRYRAILSDGQYFIQAMLATQLNHFVESKQVDKHSLVKVVNFSVNSVSGRKLLIILALEVVPWTDEKIGNPVSVDQAKSGASASAQPAGAHSAPLQSATAPAPARAQVPGRNASSARPGNTKPKGDLGPLYPIEGLSPYQNRWTIKARVTQKSDIRHYSNQRGDGKLFNVTFMDETGEIRATGFNDAVDNFYNLLEVGKVFFVSRARINIAKKQFSNVNNEYEIMFERDTEIEPCADESVPQVKYNFKGIGDLGELQKDDVCDVIGVVREVGELGSVTSRATNKPFAKRELQLVDQSGQSVRLTLWGKQAETFQADDQPVIAFKGVKVGDFGGRSLSMFSNATMTINPDIPEAHSLRGWFDAEGHNKHFTAYTTASVGDSAINTAAGAATRPAELKTIAQVKDEQLGMSEKTDFFSTEATVAFIKKDPFSYPACANPDNCAKKVVEDGSGWWCEKCQRRWDEPIHRYILSMNVMDYTGQFWMTAFNETAEQIMGISANDLMKLKNEGNDLDYDVHFAKATARTYVFQMMAKQDSFNDQVRVRYQCRKVAPPDYVADSAHLSQMISQMSV
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MATAMAFSTDFHSIKLDQRLCNLLTPRARRKMGSVNFSQINGGISISKVMPNFGAVPNVLSRRVSFTQFRDNRSLPFQLSASTTSSSGLDESVKDKKKSVLSLGDVKISIGSRDDETIQVRVDLTGEQTEKAFDDMLMSLARTAPPIPGFRRSKGGKTSSNVPKGFLLQALGRDRVTKFLIQELITTTIEDFVEREQIKVKTELSTTQTAEELESAFSPGSDFGFDATLQLENEEDGAKDEEKQSEMSTIDV
The following text describes a protein:
Function:
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling.
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MYAMASSHSSSLVPHSNSNKAFYKKGLEPAQQVGMVRSLPDVCPKEPTGDTKSLRDEPSVVADQHKWTIYHSKVNLPAALNDPRLAKRESDFFTKTWGQDFMESEVLPSPYLPAITKEQFLSYSQQTITREKSHEKWKSVCPLKEDFDRPAYSHVLKSRADLEQVPKIFMKPDFALEDSLTFNAVLPWSHFSSAGGKGSRDAASSKLLQEKLSHYLDIVEVNIAHQISLRSEAFFHAMTSQHELQDYLRKTSQAVKMLRDKISQIDRVMCEGSLRILRQALTRNNCIKIYNKLKLMATVHQTQPTVQLLLSTSEYVGALDLIATTQEVLQQELQGIHSFRHLSSQLCELEKLIDKMIISEFTSYARSDLNRLLEEDSHVVEEERLVSLVFGMLKQRKLDFFEIYSEEMMATAKTIIKQCVVNTVSQIDEIDSEIVAKLTDQIRMMSFSQWFGLLENIFSKFTIFIQRVKATLSVIRNVVLMVLDKNQRVREMEILAAQQSIRRESNVDNDLAYLTHEGLFISDAFSEGELPNAAANTNFQRNASPSSSSEPSGSDIVSDPECTTDSSSSKEHTLPSVTPGGIEIILNEEMKLTDLELGKIANSIQELLYDASDICHDRCSKFLLARAKEGFLEKLNSAEFVSLSRAVEAFVLDTEKICGRRSMSLRGALQSQANKFVNRFHDERKTKLSLLLDNERWKQADVPAEFQDLVDSIKDGKILLPERKSGGTEERKPTDFLTVDGQKYAVIGTVLLLIRIILEYCSCVDDIPSVTTDMLTRLSDLLKYFNSRSCQLVLGAGALQVVGLKTITTKNLALSSRCLQLIVHYIPLIRAHFEARMQPKQYSMLRHFDHITKDYNDHISEISAKLVTIMDGLFEKLLSKYEVKAPVPSTCFRTICKQMGKMHEAIYDLLPEEQTQALFLKINSSYIFHLKRQLCHLNVSNDGGPQHGLVAADIAFYTENVQALKGLKDLDLSLAEIWEQKR
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MASRASKARILYKTILRLHRGLPAELKEFGDRYVRDEFKRHKTAESQFVPTFFKEWTRYANTLSKQIGKSAANEKLGLGFSEEELNKLNEEQVGQLFELYQETQRVQGKDVPEISTIKSQLKEETNNNNKIK
The following text describes a protein:
Function:
GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MCTMPATRDASGSGDASTDLIAARSLSSHQGQRSNLRIFKLLISCCLLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSNNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLSRSSRILANTPDAST
The following text describes a protein:
Function:
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MANAKSSSLPSWKNPSGKTLLILLWALALALMALLSSWADMPWLSNGKLLIALGFTALVTALIGMAVVPMLVNLKASQVIQSDGPQSHLKKAGTPTMGGIFFVPVAVAIAVVGTQFNPDVIVVGLVTLGYMAIGWVDDWQILKYKSNKGLTPKQKLFLQVAIAVIFCTWLFFYGPTEITDIRIMQFVLPLGFLFWLVATFALVAESNATNLTDGVDGLAAGTGAIAFVGLGLLVAKENPALAFFCCAMAGGCIGFVHHNHNPARVFMGDTGSLALGGSLAAVGIMTGNLWGLLLISGIFLAESLSVIAQVGYYKATKGPDGVGKRLLKMAPIHHHLELSGWTETQIVGSFYLINTLLAIVAMATA
The following text describes a protein:
Function:
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Domain:
The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence:
MDAIKKKMQAMKVDKDGALERALVCEQEARDANTRAEKAEEEARQLQKKIQTVENELDQTQEALTLVTGKLEEKNKALQNAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLKSLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLIVEKERYCMIGDSLDEAFVDLIKGLEPFWNPRNPKPPTPKLPTPTPEELAAMEEARAAAEAAAAAEAEAAEAAAAAGEAGPDGAPAAPGEEKAPAKEPTPPKEPTPPPPPPPPFEYSIDLPPEGAEVPYVKNYEPPPPGSEPEPVPAAEGEAAPAAEGAAPPAEGAAPPAEGAVPPADGAAPPAEGAAPAAEGAAPPADGAAPPAEAAAAPADAAAPAAEAAPAEAPAAEATAAEAPPAEAAPAEAAPAAAEGEAPPA
The following text describes a protein:
Function:
Induces paralysis after injection into blowflies (L.caesar). In most cases is not lethal 24 hours after injection, but paralysis is irreversible. May have antimicrobial properties, like most ant linear peptides (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MRLSYISLTIAIIFVMAIVHAPETEAKAYPEADAVAEAIAVGEADAVGVADPGFKSMLAKAALKILKAVAPAAAAAIADKIG
The following text describes a protein:
Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Sequence:
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEVPLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MKAAQQAARAINPERFPLYLYKSILRLHYGLPAQARLMGDTYVKDEFKRHKTAKPEFVKPFITEWTNYCVMLSKQLSSAGIRKGNIGKDLDSDKMEQLSNEHIQQLVELRVEADKHMGRDDFLQNLQNVTESREKPI