lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Regulates the directionality of cell expansion by regulating the actin organization, and thus the microtubules distribution and the fusion of small vacuoles.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDALSRPAVVIDNGTGYTKMGFAGNVEPCFITPTVVAVNDSFSGSGQPAARGAPARGNWLAQHSAGVMADLDFYIGQEALARSRASSSHSLSYPIRNGQVENWDSMERFWQQCIFNYLRCDPEDHYFLLTESPLTAPEIREYTGEIMFETFNVPGLYIAVQPVLALAAGYTTTKCEMTGVVVDVGDGATHIVPVADGYVIGSSIRSIPITGKDVTQFIHQLLKERGENIPPEESFDVARRIKEMYCYTSSDVVKEFNKHDREPSKYVKHWTGIKPKTGAKYTCDIGYERFLGPEIFFNPEMYNNDFTTPLQVVIDRCIQSSPIDTRRALYKNIVLSGGSTMFKDFHRRLQRDLKKIVDARVRASNSRLLSGDAKFFSDNIIYDFQAQPIEVNVVSHPIQRYAVWFGGSVLASTAEFYEACRTKAEYEEYGASICRSNPVFKGMY
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MIAFLLAFLAALLCESVHSEGSSVAWCYNDPACNFTTWPELAPHHCNGSSQSPINIVTAQVQENPNLTQFKLTGFDANTTFTSITNSGVSVVVNLDDKIMSVQGGDLPGLYVSKNFHLHWGSGSSLPGSEHTVNGKQYAMELHIVNVHSKYNGSVSVALAAHDSSALAVLGFFIEGTDEANKTKGWDVLTSFLTKIPNKNDTTVDIMNQITMNSLLEGVDKTKYYRYQGSLTTPDCNEAVIWTVFKEPIKVSNNLINRFSTTVFTKTTSAPVLIFNNFRGVQPLNGRVVTSQVEQTGSSAAPLSPTTSISSFTLLLLLFSLCCL
The following text describes a protein:
Function:
Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen.
Sequence:
MRWNRMNPFGSYKKVVSARSTLKEVLKKAQDGGIVSTAFIYGLENNLLDGVIVADNAGEFKAVPKVATTPEEVLEAAGTKYTVCPNISVLKSAVREYGCEKIGVVGTPCQVRAVRKLMKYPVGFRHVPDKIALIIGIFCMENFPYYGLKLIVEEHCGVKMEDVVKMDIGKGKFWVYTRWGETKAIKLKETHPYEQIACHVCTDYTAELADISTGSVGSPDGWSTVFIRTAKGEEIFNKMVEDGYLEVKPIEEVKPGLGLVEKLALQKKEKNMKEIEHRKELGLPIPY
The following text describes a protein:
Function:
Antiapoptotic factor that may have a role in protein assembly.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly nuclear.
Sequence:
MPTVEELYRNYGILADATETAGQHKDAYQVILDGVKGGAKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGDNLPRVADILTQLLQSDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPEEVLTKEVEEFILAESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTKFVTYFCEHVLPNLSALTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLESNLKKLFDKLLEYMPLPPEEAENGENAGGEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKADANQKRTSEDTTSSSPPKKASAGPKRDARQIYNPPSGKYSSNLGSFSYEQRGGFRGGRGRGWGGRGNRSRGRIY
The following text describes a protein:
Function:
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MMLLQLNNVSVGTRLASFSSQVTTGLQIHLIGPNGAGKSTLLASLAGLLPASGEIVLAGKSLQHYEGHELARQRAYLSQQQSALSLMPVFQYLSLYQPAGANSQAVATAISYICNKLRLTDKLPRMLSHLSGGEWQRVRLAAVFLQVWPDINPDSKLLLLDEPYSGLDVAQKVALDALLVEFCRSGRSVIISGHDLNHTLQQADEVWLLAQGQVLVQGETQQVMRADVLSQVFEVDFQIHNFNKQQWITTRSV
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEEDNLDLEGMDIHSGLDSSFHSPPHTSDPAGLSMDETDDIDDLINNVRPHDPLGTLEEKEADIKELTHSWVTERMSPTLLPTKEALLFRILKRVQLQIEVIEEKSIDMSPDTDVKLELLIVETELERIKYLIRSYLRVRLLKIDNSMEYYQSSPLDRMNMSQTERMYLNRHYALLKNLYAHQFMNTFPDSLKQMNDSSGSASMVQEPNMDHPVFVRVVKDTGRKIIIGNDSVKLRKGSIVVIKYSIIVKYVESGDVVFI
The following text describes a protein:
Function:
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, leading to the recruitment of centriole biogenesis proteins. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MTTQYMGDSIEDFQVLDLLGKGGFACVYRGRCLATGQEVAIKMIDKKAMRTAGMVNRVCNEVEIHCRLKHPSILELYTYFEDDNYVYLVLELAENGEANRYLRKQGHTLKESEVRRIMLQVVKGVLYLHSHGIIHRDLSLGNILLSSDMDAKIADFGLATRLSLPDEKHYTMCGTPNYISPEIATRDPHGLESDVWSIGCMLFTLLVGKPPFDTEAVRSTLNKVVLAEYDIPNHVSIEARDLISKLLKKNPQDRLTLSGILDHPFITNQTLNTKYSSPTRQHLNPRAYENSLDSGTGTMATISTGHAPFQQDNRHAVKSSSAERTSDIWPRDPKHPPSPPVRQRPSSCPSTENVTTGSSSHVRGSDVAQPAQYSGLKTRTSDSWLSDIHSSKIPKLPQKPLVGLDKMNGIQSKFKSYNATKYSSYYGSTLGDILHLAGQQNGTNTSSSGFYSADTKSYSANHGLKTSSTDHNNKESCQTRDNHMYEKSIEQPSATKSEHSRAYSSQDSRPHSHHKRHGSDSVSKDFDASPQPSQGESRRRQNHRSDSERQTRRAEKSRSGGRDKSLGELTEPLNAERLRPIRQKTRNAVVSITDEAEVCLEFLQQKGGQSIVTEVIRIASNGMKISVYQPSEAEKVLGSEPPLPPSAGNGSYLFPSLPSKYWKKYKYAAKFVQLVRKLTPKVTLYSKHAKCVLMENYPHADFEVCFYNGAKVHQSQECTRIIEPGGVSYTLESVGGIEGVPVEMRKLIQHVKAAYQQCVRLERIIMQEEKESNGNQYFPFIVGRRPPAWKNSSGKSEKQDQQGCSNGQSQPVLPSSPSIAAPAMTSLLSFDGTIASTAQTTNPAFPGKSRKTSPSKTSRHKQSPAQPIPAEVANAKTDPSPHHYVEGSSPIPSAHVCKMAFVDGVGWSSQLTTGEVWIQYTDGSQIIFHAAAAAIKFTDSTGNVTRYGYADRLPSVIKEKLSHLPAVIKTLATTSKVS
The following text describes a protein:
Function:
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Sequence:
MENTFVLSKQIHHERQELCTNRPRYRQGKKLTAVKVYSVVDESQYLLIDKVPAIAVTAELETLCQGFGSIEYLKHLPDYPTEKFCEVFQVKFHTIQSARFAKRKMDDRNFYGGTLHVCYAPELETLNDTRSKLNNRRQEIENKLKAPQNRKHKLLSATSTSAEQVHCPSLVIKEPISDSNAECFTTTEPPNSEESQKVTVAGKQPQPVCEPPKKRIVYHVSSKTPR
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSCIGIVGKDFVLMAVDGNSGRGVITVRNDFNKIYPVQGNRLLTIIGEGNDRQVLADFVQRNIALNYYRNGLKSTTQSIAHWIRRQVSDSLREGGYQCSMLLGGVDEKPELFMIDQFGTLVPETYASHGIGSNFVYALLDKNWHSGMEFEEALELMKKCIKEIQKRVIVSSSHYCIEVCYKDKTELIQGPEVFPPVN
The following text describes a protein:
Function:
Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP), probably via metalloprotease activity. Regulates gibberellic acid-mediated salt-responsive repression of seed germination and flowering via FT, thus delaying seed germination under high salinity conditions.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Nucleus. Note=Localized primarily in plasma membrane as dormant form and, upon salt stress, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP).
Domain:
The NAC domain includes a DNA binding domain and a dimerization domain.
Sequence:
MSKEAEMSIAVSALFPGFRFSPTDVELISYYLRRKIDGDENSVAVIAEVEIYKFEPWDLPEESKLKSENEWFYFCARGRKYPHGSQSRRATQLGYWKATGKERSVKSGNQVVGTKRTLVFHIGRAPRGERTEWIMHEYCIHGAPQDALVVCRLRKNADFRASSTQKMEDGVVQDDGYVGQRGGLEKEDKSYYESEHQIPNGDIAESSNVVEDQADTDDDCYAEILNDDIIKLDEEALKASQAFRPTNPTHQETISSESSSKRSKCGIKKESTETMNCYALFRIKNVAGTDSSWRFPNPFKIKKDDSQRLMKNVLATTVFLAILFSFFWTVLIARN
The following text describes a protein:
Function:
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular Localization:
Mitochondrion.
Sequence:
MGNFSSSAPGLSSSACGQFVQDIVSSNCVVIFSKTTCPYCKMAKGVFNEIGATYKVVELDEHNDGRRLQETLAELTGARTVPRVFINGQCIGGGSDTKQLHQQGKLLPLIEQCRPCCLNMTPEGSGNSQNQPHQ
The following text describes a protein:
Function:
Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells. Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSEVIRGTADMVLELYVSDREGNDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWDVISKSQMKNIKKMWHREQMKSDSREKKEAEDNLRREKNLEEAKKIIIKNDPSLPEPACVKISALEGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLSDDLCQCYNGVVLSTESSVAVYGTLNLTPKGKQAPGGHELSCDFWELVGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMITRCFRDHFFDRGYCEVTTPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEFTHVEAECPFLTFEDLLSRLEDLVCDVVDRVLKSPVASIVYDLNPNFKAPKRPFRRMNYSDAIEWLREHDVKKEDGTFYEFGDDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRSWDSEEILEGYKREGIDPAPYYWYTDQRKYGTCPHGGYGLGLERFLSWILNRYHIRDVCLYPRFLQRCRP
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDGDPAVMKVPRSSSVEVKEDMDTKSEKQATGDTLIDISFCGSTPMLWKVPDMKKCRSEGVIGALVGSLARQPRQNVRLGRPLELRPEEALLLLEEEKSTAAVRLDTQQDFEDREAHSEAVRLYEASLESSYQEQCVLALEDKKKTLNRVMNEKENGTEGSGSAVRERLEALDQSFRFPWSAMAVQLCTARSGFSHCPEERSFHSTDCPMPRDEHLNTRFSVYRDLRNKGYYLTSAGKFGGDFLVYPGDPLRFHAHYIALCVSLDEEMPVCDILAIARLGSNVKKTVLLCSPQDGDVVYSSLQWSSMV
The following text describes a protein:
Function:
Involved in efflux of free sulfite. Mutations in the SSU1 gene cause sensitivity to sulfite.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVANWVLALTRQFDPFMFMMVMGVGISSNILYSFPYPARWLRICSYIMFAIACLIFIAVQALQILHLIVYIKEKSFREYFNDFFRNMKHNLFWGTYPMGLVTIINFLGALSKANTTKSPTNARNLMIFVYVLWWYDLAVCLVIAWGISFLIWHDYYPLEGIGNYPSYNIKMASENMKSVLLLDIIPLVVVASSCGTFTMSEIFFHAFNRNIQLITLVICALTWLHAIIFVFILIAIYFWSLYINKIPPMTQVFTLFLLLGPMGQGSFGVLLLTDNIKKYAGKYYPTDNITREQEILTIAVPWCFKILGMVSAMALLAMGYFFTVISVVSILSYYNKKEIENETGKVKRVYTFHKGFWGMTFPMGTMSLGNEELYVQYNQYVPLYAFRVLGTIYGGVCVCWSILCLLCTLHEYSKKMLHAARKSSLFSESGTEKTTVSPYNSIESVEESNSALDFTRLA
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MPPKNNQSGFMSVEQRSEIGDFSRHTPARSLVQPRNRSILATASRRTGTQSQHSPTRMTVETHEAVYWGTNIDERAIEKQFDRFLKEYRSGGMEYYMSQLNQLNETDQFILNIDGRHLLEFNNHLYQQLIHYPAEIIPIFDTVVQKVFYDDFLSLKARNEQEREEFRLYAQRLLIGIINLERNVQVRELNPKDINKLISVTGIVIRCSELYPDMKQATFKCTKCGHIVGVNIERGRVEEPISCQRCRDKNSYELIHNLCQFTDKQYVKLQEQPENVPEGYTPQTVNLVPYDYNVDDVKPGDRIIVVGVYRAAPIRQTKNRRVLKSIYNTFIDVISYQKETKIEQEKTKNITEEQKQKLMYLSQQSNIYDRLVKSIAPSIWEMDDVKKGVLCQLFGGTNKEFSQAGKGRFRADINVLLVGDPSTSKSQILQCVHQLSSRGIYTSGKGSSAVGLTVYVSRDPETREIILESGALVLSDMGICCIDEFDKMDENAKTILHEAMEQQTISVAKAGIVSQLNARTAVLAAANPLKSRYDVKQSVVQNINMPPTILSRFDLIYLVLDEFNEKRDEMLAYHILNMYSLKDQQDYLNQIEEEGNTDLIDRETLYSYICYAKQNIFPRLTEEAQNELIAAYVKMRSAGNSSNTITATPRQLESLIRLSEALAKMQFNQRVENYHVSEAVKLMETAMKKAALDPITGKIDMDLLATGRSNASRELVSKFIVEITNLIKANLSDYRGQGVRFFDFVEQINTIITAQTNEQTIVDKRQYQKEILEALHLLEEQGFVQLPGDRNKPKIKAGIKALQ
The following text describes a protein:
Function:
This calcium-binding protein is found in the basal body complexes (the functional homolog of the centrosome in animal cell). In mitotic cells it is specifically associated with the poles of the mitotic spindles at the sites of the duplicated basal body complexes.
Sequence:
MAEAAEANADLKNEYGFTDAQIAEFREAFAMFDRDGDGTVSTKELKDVFSNLGLDLSDEEITDLVMQVDLDASGTMTLTEFCILMAKTGLVPDDPEAELRAVFNAFDDDKSNHISMKELQAIMLKLGEKLADDEVEAIFKEAGCTSVDAETHELTMTFKNFKDIMKGANRS
The following text describes a protein:
Function:
Activator of the glucitol dehydrogenase gene (gutB).
Sequence:
MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDKIALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEATTIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTEQPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCVDDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALANYTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQLSGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMALSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSKPPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSEQHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQWASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSGWALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETILNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYFNLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESNQKAIRLIDSWEPAIGIRGEVERLARATKENE
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MTDVEVTYEDFIASGRTGRRNAVHDILGSSGGLDASGLSQTLSELSIGKPGNDEEKDQRSTDSEPKQEEANGEGT
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MSSSRLPSTATQRQKVAQFVAVTNASKENAQRYLRNANYSVELAANMYMNDRERKRGPDDALNQLFDRLVGDEDRAAAGAGKPVEAIGAEAAQAYISSMGANIENVEAFVVLEIVRADSIGQITRQGFVEGWSSIYLDHRIPADPAHHRNYVRMCIQNLPQNPAYFKKVYQFAFGLGKEPAQKALEKDVALVFWDLFLGTESSDTGLGPRPWKSKNVDWLGAWKRFLAEKWTRSVNKDMWNQTLAFAEKTMVDETLGFWNEDQAWPGVIDDFVLWCREQGIAKAPAPGAAGGEGMDVEDY
The following text describes a protein:
Function:
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process. Has very low activity toward hydroxylamine. Has even lower activity toward sulfite. Sulfite reductase activity is maximal at neutral pH.
Subcellular Localization:
Periplasm.
Sequence:
MNDLNRLGRVGRWIAGAACLFLASAAHAEPGENLKPVDAMQCFDCHTQIEDMHTVGKHATVNCVHCHDATEHVETASSRRMGERPVTRMDLEACATCHTAQFNSFVEVRHESHPRLEKATPTSRSPMFDKLIAGHGFAFEHAEPRSHAFMLVDHFVVDRAYGGRFQFKNWQKVTDGMGAVRGAWTVLTDADPESSDQRRFLSQTATAANPVCLNCKTQDHILDWAYMGDEHEAAKWSRTSEVVEFARDLNHPLNCFMCHDPHSAGPRVVRDGLINAVVDRGLGTYPHDPVKSEQQGMTKVTFQRGREDFRAIGLLDTADSNVMCAQCHVEYNCNPGYQLSDGSRVGMDDRRANHFFWANVFDYKEAAQEIDFFDFRHATTGAALPKLQHPEAETFWGSVHERNGVACADCHMPKVQLENGKVYTSHSQRTPRDMMGQACLNCHAEWTEDQALYAIDYIKNYTHGKIVKSEYWLAKMIDLFPVAKRAGVSEDVLNQARELHYDAHLYWEWWTAENSVGFHNPDQARESLMTSISKSKEAVSLLNDAIDAQVASR
The following text describes a protein:
Function:
Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Up-regulates the expression of most toxins and genes known to be necessary for biofilm formation.
Subcellular Localization:
Membrane. Note=Membrane-associated.
Sequence:
MKKLYTSYGTYGFLHQIKINNPTHQLFQFSASDTSVIFEETDGETVLKSPSIYEVIKEIGEFSEHHFYCAIFIPSTEDHAYQLEKKLISVDDNFRNFGGFKSYRLLRPAKGTTYKIYFGFADRHAYEDFKQSDAFNDHFSKDALSHYFGSSGQHSSYFERYLYPIKE
The following text describes a protein:
Function:
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (By similarity). May be involved in regulation of behavior and circadian rhythms.
Subcellular Localization:
Nucleus. Nucleus, nucleoplasm. Cytoplasm.
Sequence:
MDSEFLELTQLLPRWVDLENVVRGEVEARYILKRAADHLANLRSGGDSGAEETGYLVGALVDRNWERIHTGHFSQVPLVTRKIYAIACCFKIFFLLLESTSPAQKDACSEILDEAQLLGCMEDWSELKVALMDYLDKDGAVALNSAPLPTLEPLTRVTSNCDIPQLDAPSLEEFQTKCFEAGQPTLLLNTIQHWPALHKWLDLNYLLQVAGNRTVPIEIGSNYASDEWSQQLVKIRDFLSRQFGKEPSKAGQNIEYLAQHELFAQIPALKEDISIPDYCTISNEDTPGAVDIKAWLGPAGTVSPMHYDPKHNLLCQVFGSKRIILAAPADTDNLYPHDSEFLANTARIDAAQLDPETYPLVAKVKFYQLLLQPGDCLYMPPKWWHYVRSEAPSFSVSFWWE
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MEAMKVALVALLLTVCRGSPIAKQRLPNPLIQSNSLLSQYIMMIMDHILQANKGMDLFEGDIKGVDWTTRNAIRDRTKIWQTREVPYSIDPSVSPEAQAAIQEAVQEFHTKTCVRFKQRTTETDYILFKKIGGCWSNVGKTGGMQELSVGDGCEFKGTVAHEMMHALGFWHEQSRTDRDNYINVMWQNIQDGKEHNFNKYSQDQVDTLGMPYDFGSIMHYSQFAFSKNGQPTITPKQSTADAIGQRNGLSDTDVQKIQLLYSCTGGGSGTTGTAATTVTPNNWSSWSSWSECSLDCRKTRQRFCTDANNVGCEGDSTEVAECPLPCFPVTAIGCWVDNLGSPPVPSMENSEPSLADNYRTRTSAIRKCADVAYARGYQGPIPGQWGEWGPWGTCTKTCGIGTQYRYRQCDNPPPINGGANCQGNTFEAQFCNTHECPANPVCGPPDLTGPSGEIKLTTYPAPYDPYLSCEYNIDGQGLPVTLEFLDLDIEYASRCVYDYIKVYDGTSQSDAMLGNICGTTSPGTITSSGDKLFLVFKSDDSTNGRGYRIRFSVVTPSQATTTTTPKPTTTPQPTTTPRPTTQTTTTPRPTTQTTTTPRPTTQTTTTPRPTTQTTTTPRPTTQTTTTPRPTTQTTTTPQPATTPRPVATTVTTTPAPVSTYVDNCQNLSPLCGANPGWPSFDMCNTDYVRDNCPQFCGLCTCDNRPCYNGGHRGGNPDNYGENTCDCNCVGHWSGPTCQVCNLQCLNGGVLDQSSCTCLCAAGFDGETCTEPCGDSSHLCGANPGWPSVDSCVHDYVRDNCHAMCGVCNLAPTLAPTGAACQNKSPLCGANPGWPTTESCRTDYVRENCPQFCGLCSCGKTCANGGTVAGNPNSYLEHTCDCNCVGLWSGDLCDECTVQCLNGGTIDRSTCTCSCPPGFSGEKCEGKQTHDSPAESCQNVSPLCGRSPGWPYVSQCSTDYVKENCQQFCGACSCSDTPCANGGTRGGNPDNYGVHTCDCNCVGMWSGPSCQECNVQCANGGVLDRSTCTCQCADGFDGETCTEPCRDSSDLCGANPGWPSADLCSIDYVRDSCHAFCGICVP
The following text describes a protein:
Function:
May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, flagellum axoneme. Note=In multi-ciliated cells, localizes to the basal bodies and in non-ciliated cells, to the centrosome. In spermatozoa, colocalizes with microtubules along the length of the axoneme from its proximal end to its distal tip and with tubulin at the distal end of the flagellum and at the proximal centriole.
Domain:
The Mn regions are involved in microtubule-binding and stabilization at low temperature. They are required and sufficient for cilium targeting; The N-terminal region (residues 1-29) might play a role in centriole retention.
Sequence:
MKTKCICELCSCGRHHCPHLPTKIYDKTEKPCLLSEYTENYPFYHSYLPRESFKPRREYQKGPIPMEGLTTSRRDFGPHKVAPVKVHQYDQFVPSEENMDLLTTYKKDYNPYPVCRVDPIKPRDSKYPCSDKMECLPTYKADYLPWNQPRREPLRLEHKYQPASVRFDNRTTHQDDYPIKGLVKTISCKPLAMPKLCNIPLEDVTNYKMSYVAHPVEKRFVHEAEKFRPCEIPFESLTTQKQSYRGLMGEPAKSLKPLARPPGLDMPFCNTTEFRDKYQAWPMPRMFSKAPITYVPPEDRMDLLTTVQAHYTCPKGAPAQSCRPALQIKKCGRFEGSSTTKDDYKQWSSMRTEPVKPVPQLDLPTEPLDCLTTTRAHYVPHLPINTKSCKPHWSGPRGNVPVESQTTYTISFTPKEMGRCLASYPEPPGYTFEEVDALGHRIYKPVSQAGSQQSSHLSVDDSENPNQRELEVLA
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Miscellaneous:
MISCELLANEOUS: Present with 2710 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFTFIPITHPTSDTKHPLLLVQSAHGEKYFFGKIGEGSQRSLTENKIRISKLKDIFLTGELNWSDIGGLPGMILTIADQGKSNLVLHYGNDILNYIVSTWRYFVFRFGIDLNDHIMKDKEVYKDKIIAVKSFNVLKNGGEDRLGVFDSFQKGVLRSIVAKMFPKHAPTDRYDPSSDPHLNVELPDLDAKVEVSTNYEISFSPVRGKFKVEEAIKLGVPKGPLFAKLTKGQTITLDNGIVVTPEQVLENERHFAKVLILDIPDDLYLNAFVEKFKDYDCAELGMVYYFLGDEVTINDNLFAFIDIFEKNNYGKVNHMISHNKISPNTISFFGSALTTLKLKALQVNNYNLPKTDRVFSKDFYDRFDTPLSRGTSMCKSQEEPLNTIIEKDNIHIFSQNKTVTFEPFRMNEEPMKCNINGEVADFSWQEIFEEHVKPLEFPLADVDTVINNQLHVDNFNNSAEKKKHVEIITLGTGSALPSKYRNVVSTLVKVPFTDADGNTINRNIMLDAGENTLGTIHRMFSQLAVKSIFQDLKMIYLSHLHADHHLGIISVLNEWYKYNKDDETSYIYVVTPWQYHKFVNEWLVLENKEILKRIKYISCEHFINDSFVRMQTQSVPLAEFNEILKENSNQESNRKLELDRDSSYRDVDLIRQMYEDLSIEYFQTCRAIHCDWAYSNSITFRMDENNEHNTFKVSYSGDTRPNIEKFSLEIGYNSDLLIHEATLENQLLEDAVKKKHCTINEAIGVSNKMNARKLILTHFSQRYPKLPQLDNNIDVMAREFCFAFDSMIVDYEKIGEQQRIFPLLNKAFVEEKEEEEDVDDVESVQDLEVKLKKHKKN
The following text describes a protein:
Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Sequence:
MPDHAFWNTQPVVQELVEALEDGDMPQDLISVDPAQHPDTSIPLPEKFVWTAIDPHDDGHMADLYKLLHAYYVEDTSNMFRFAYSKDLLRWWLTSPGCKPEYSLGIRIDDPDSEGHGRLIGYISGVVSDYAYSNVDGGEVFSRPMQSIVFLCLDKKYRSLKLAPLLIQEITRRSYKNGVFHAIYTSGTSLTAPIQVATYYHRILNPLKLARIGFCTKPKAISDKEFAFFYKLPFLPTALSSCFHVCTEADIPVLYDLYLEYTRRKYKFRQIYSKEMFTHVVTHRKDSIHTLVYREKEGGQPDAFITYYIIDTAVLAKDIRKQYPNMRNGYIYLYSLRDDCNLSIGQLVLALMHDMQNNNIDVCTALNVGLNPSFFSTMKFAEGSGKLNYYLFNLKWPKMALKDIGVVLI
The following text describes a protein:
Function:
May be involved in the Ras/cAMP signaling pathway.
Miscellaneous:
MISCELLANEOUS: Present with 222 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MQKSVRVGDYFDNDDNGLWSWYLTNLRLGDFEELIGNQLKYTLLKRFLNSHFYGDNNISARPNKKILLVSIPENVHEDISILEIFLKDYFHLEKLEHIQISKLTHSHCYNHENHYLLTDNLNNFQDPTFLEFASTSWQVQKNSKALNNNNRNSIPPPTISSSKASNGKLESNVSDDQWSNINTQTSTATRTNTNTRTLTSPDTVDINVTSVNSQSNNNDTPQDNENEVDEEDATSSIVLNFSHSRTVDSKPNRLPKIFPSYTNEDYTPSHSEIMSIDSFAGEDVSSTYPGQDLSLTTARREDESGQDEVEDHYSRVSHDLGDESIDQASYSMESSVSYTSYSSSSNSSSAHYSLSSSSRGNPKRENIDHTNATYVSELSSITSSIDNLTTSTTPEEEDNLIHHNYDAQGYGSGEDDGEEVYDDEDLSSSDYSVLSILPSISICDSLGYFRLVLQSILIQDPDTKEIFTAIRQSNNKPTMASVTDDWLLYDSNFSMNNLQILTLQDLLDIKRSFPKILFYTMVIVTNSGKQVEEEFKNPNYDNREGISKEQPLDSELSLTNDPQQYFPTAYNNGYNDYIDDEDDEDDGDDASLSEQSGPQMYIPTRMESNVTTAHRSIRTVNSIGEWAFNRHNSVTKIDKSNSNELDNSKTGESTVLSSEPHPMTQLSNSNTTSSNFSHSLKTKNSHKPNSKGNNESNSKNELKKIKSSINAMSAVERSKSLPLPTLLKSLSGIDNPTHATNKDRKRWKFQMNRFKNHKNSGSAGTDKSQRCAIM
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDGQSADASRPSLQDRLKQLGETIPRPMWSSRELVERNIDLMLRNAQTCMVELAREKQPTKNSAQNKMDDASQNFRAALNFVESTLSSNMAYLSNVCVGTPHQGSTFSAHHKMGLAAQCEQSLHSELASLNKFHFHKEMSNQPCGSKSIVDSILTRPSLNAPSILRRKRKIPMNEDVHSSPISKGYVETDKRIDYVRDLASKYTPNSLMQIRSCPIETMQSGIVIGRLRGKGANCDLTNISCRVDLCGRQFDTVQVLAWHMSYSHTDLSSTGSIASFCFVCGHQMSSAKGKVAHLLSKHRELFQQHHQQCLNQQQVVYAPNAPGAARLRENRLEAEMMLKHDQMGLEI
The following text describes a protein:
Function:
Part of the ATP-binding cassette (ABC) transport system AztABCD involved in zinc import. Binds zinc with high affinity and specificity and delivers it to the membrane permease for translocation into the cytoplasm.
Subcellular Localization:
Periplasm.
Domain:
The D-loop is required for the efficient acquisition of Zn(2+) from chaperone AztD; The Z-loop functions to lock down over the zinc binding site, decreasing the rate of zinc dissociation. May also inhibit the formation of productive interactions with AztD for zinc transfer.
Sequence:
MKDWLFRIATCSIMTFSSLAAAQAEPLDVVATFSIIGDFAAKVGGDRIRLNVLVGPDSDTHVYEPRPADAIALAGADVVLTNGLEFEGFLTRLIAASGTDAAVATLTDGVETMEEPGGGHYHYIDGKAVFHAGAHDPHAWQAVPNAKVYVQNIAAAFCAADAEGCAAYQANAARYIGELDALDTEIRAAIAALPQDRRTVVVAHNAFRYFEAAYGVHFLSPQGVSTESEAAAADVAGLIREIRARNASAIFAENISDTRLLEQIAREAGLPLAGTLYSDALSGPDGPASNYIAMMRHNAGAIAAALAAR