lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTIQFILDPTQLTKKDLAIYSCFICRDISFDDYLYQCSKGHTACKGCWARHLRTKKTCMECIEKINSLENLSTNRKLRELLFKKKFKCPYHYSNIIKSDDSEPLTNTGDGCKEIIIGEKLKNHIENCEYRFVKCKNEKNGCNFNSRFKLYHSHEDLCLYKYIPCFYCKSLIVKNNEINHQVECESFPVECKLCQNQFEKREINDHLANNCLESLIPCPLEEFGCKEKEKRSKIQDHLNGNHNTIFIEQIKKIHQLQNEIYNQNQSIINQNETISRQGQEINNLKENIHIIKKDLENFKLNLPTTTNEQFPEINKIQKPEIHTNYYKNFSYKNTWIIENYSKITSTICNVSFDPFNFEINLNKREINGENVVELSVYYCKDFEINVNFSFILQNHKKITTLKERFNKDFTEKYFLKKTAYGWQKAFREAINKKNGWLTKDDTMVLEITFKCSSIVKPLFS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of bioactive endogenous fatty acid amides to their corresponding acids. The hydrolysis of endogenous amidated lipids terminates their participation as lipid mediators in various signaling systems (Probable). Converts a wide range of N-acylethanolamines (NAEs) to their corresponding free fatty acids and ethanolamine.
Subcellular Localization:
Endoplasmic reticulum membrane. Cell membrane.
Sequence:
MGKKRVMVPAKDVDLSSIKYEPEIVQAPHLTGFWFRFFVRLIEAPLIGPFLLTMLKKENKIDQLLRNTVFPEEPMFKPEYPPQEKEHSVVELDEDGRPEGRVESALNCLPHYDPAKLWENSSATFRYWKIRDYAYAYQSRKVTPSMVAESIISMIEENGIDKPPTPLLLSFDAAEVRKQAAASTQRFESGNPLSILDGIFIAIKDDIDCHPHPSTGGSTWMHEVRDVKKDAVCVSRLRSCGVIFIGKTNMHEFGMGTTGNNSNYGTARNPHAPDRYTGGSSSGPAAIVASGLCSAALGTDGGGSVRIPSSLCGVVGLKINYGRTSMEGSLCDSGTVEVIGPIASTVEDAMLVYAAMLGASPANRISMKPSTPCLPTLSSDDDTDALRSLRIGIYTPWFNNVHSTEVSDKCEDALNLLSKAHGCEVVEVVIPEIVEMRTAHLVSIGSECLSSLNPDIEDGKGVKLSYDTRTSLALFQSFTAADYVAAQCIRRRIMHYFMEIFKKVDVIVTPTTGMTAPRIPPSALKSGETDMPTTGYLMRFVVPANLLGLPAISVPVGYDKEGLPIGLQVIGRPWAEATILRVAAAVEKLCGESKRRPVTYYDVLGAN
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Sequence:
MTSLIHLSDLAGDSDLHLSLQGGAVSIGNFDGVHLGHRALLERVRWHAQRVGGKAIAIVMDPHPASVLRPHGAPPSLTSLSRRAELMSGSGIDHLLVCEATRDFLNQTAEEFFQRLIVEQLSAKAIIEGPNFFFGRDRAGNTTRLKELAAERQIDVEIVVPSVRDERMVSSSRIREAIASGDIVLANQMLGSRYRLTGVVTTGEQRGRTLGFPTANLGGVTTLLPEHGVYAALACGDECDGPTNHPAAVHIGPNPTFNERQETKIEAHLLDYDGDLYGKSLSLTLVSQVRGVIKFADASALKQQLQIDLQTVRETVSSLQSRP
The following text describes a protein:
Function:
mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.
Miscellaneous:
MISCELLANEOUS: Present with 3920 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNLLETRRSLLEEMEIIENAIAERIQRNPELYYHYIQESSKVFPDTKLPRSSLIAENKIYKFKKVKRKRKQIILQQHEINIFLRDYQEKQQTFNKINRPEETQEDDKDLPNFERKLQQLEKELKNEDENFELDINSKKDKYALFSSSSDPSRRTNILSDRARDLDLNEIFTRDEQYGEYMELEQFHSLWLNVIKRGDCSLLQFLDILELFLDDEKYLLTPPMDRKNDRYMAFLLKLSKYVETFFFKSYALLDAAAVENLIKSDFEHSYCRGSLRSEAKGIYCPFCSRWFKTSSVFESHLVGKIHKKNESKRRNFVYSEYKLHRYLKYLNDEFSRTRSFVERKLAFTANERMAEMDILTQKYEAPAYDSTEKEGAEQVDGEQRDGQLQEEHLSGKSFDMPLGPDGLPMPYWLYKLHGLDREYRCEICSNKVYNGRRTFERHFNEERHIYHLRCLGIEPSSVFKGITKIKEAQELWKNMQGQSQLTSIAAVPPKPNPSQLKVPTELELEEEDEEGNVMSKKVYDELKKQGLV
The following text describes a protein:
Function:
G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor. APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G-protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy. However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane. After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity).
Domain:
The hydrogen bond between Asn-44 and Asp-73 is crucial for beta-arrestin signaling induced by APLN/apelin-13.
Sequence:
MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGNGLVLWTVFWSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDIPENSTKTQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSSSAEKSASYSSGHSQGPGPNMCKGGEPMHEKSIPYSQETLVD
The following text describes a protein:
Function:
Key structural protein of the Golgi apparatus. The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon. Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks. However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity).
Subcellular Localization:
Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGLGASSEQPAGGEGFHLHGVQENSPAQQAGLEPYFDFIITIGHSRLNKENDTLKALLKANVEKPVKLEVFNMKTMKVREVEVVPSNMWGGQGLLGASVRFCSFRRASEHVWHVLDVEPSSPAALAGLCPYTDYIVGSDQILQESEDFFTLIESHEGKPLKLMVYNSESDSCREVTVTPNAAWGGEGSLGCGIGYGYLHRIPTQPSSQHKKPPGATPPGTPATTSQLTAFPLGAPPPWPIPQDSSGPELGSRQSDFMEALPQVPGSFMEGQLLGPGSPSHGAADCGGCLRAMEIPLQPPPPVQRVMDPGFLDVSGMSLLDSSNISVCPSLSSSTVLTSTAVSVSGPEDIGSSSSSHERGGEATWSGSEFEISFPDSPGAQAQADHLPRLTLPDGLTSAASPEEGLSAELLEAQTEEPADTASLDCRAETEGRASQAQATPDPEPGL
The following text describes a protein:
Function:
A component of the complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MVNNVVSIEKMKALWHSEVHDEQKWAVNMKLLRALGMFAGGVVLMRSYGDLMGV
The following text describes a protein:
Function:
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
Sequence:
MKGSGDKRRGDRRSAGSRASEPAVQSRALGSDDSDDNSNTDILVGRHRKSGRVGRAQQAHNSRNIEQSARGKSSRALHSDPVAAVVEACAEAHATSDTLSDDEFKRYDAGFESDDVFENEGMLGTSQKEEPTLSMSSLGSMGQKSPSRKRDSHMRPAMIRPDGKRSSSVSPSSPQLKYKKGDVVSTPNGIRKKFNGKQWRRLCSKDGCTKESQRRGYCSRHLSLRGKGLQSKGNLAGVEKGMLPPAEARLQVDTEDSLQSGRDRYAALDRKHSDMDETEAANMLVSLSNSRSATPCFSPHPGTPLPISPGSHSLSPMMGFHPVNFSPVNVQPAPLSQSELVSPTFKQWGPSYARSTSKSVPPVLETTTPHLKSSPPQRRQDVSVMVSPSKVKADAIVSPPARYQDMMVTQKTTLHETVSDHRNSSTTTLSSPGVPGRDPGMVFRHIPFEHHQPAGRPPHKETVQSVIPTHHRRHHRSAEELGRNPHQTPSDHIQQTDPQVPVKANVTVAAENPGSRSCPTKVTTPSLPPLSSKNYPACPSQPLSTQSTQTTQTQPRQDPTAHPPPLALLLPVMNPSQPTPAETRPQKSISPPVLKLSQVYSKAEPVAVLVYPWHCLLPILQPWSSSREERPPATLTTTQPAPEQDEKTTDEESSDLSMCHPRRRMSVGAGSDLELDVGLITERKPPSAKRRTQSLSALPKDSDCKEGRGSRKKDKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPREKQKYHDLAFQVKEAHFKAHPDWKWCNKERKKSSSSTGSGGRRQEQERKLSDDMPSSPSTTQAQTSSGETVKTEAAVQVTAVPASAVKSEDPQAAQQSSKEHSGISYAGKGGVMPEAPFSGRGRSRLESEDTISDDEQMMICEEGDDDVLVDPPGQDPDIDLKCKEMVTESDSGSQSEDEVMIENKIFPQQRFSPAMKPALPGDITFRPKPIKLRPEPQQNTNIQVSRMTSNMETQGHVSVSQIPFSRPIISSSSFQPKGAVFKVHSPKGHLGGTVMSRQTVVSSTLSSDLRTTRRDAGSYGPIPSRTEGSHGGMFVEQSSVRFSVPKATYTSSVHFQTDTGSSITQPVDAFAKSASQMGNFAPLSSLTAPCSPRTVPSTGKDKSGRSVEYCRTSSAGLSNRSSDARPFLPDPTAISKSTVVDSSRKVSFAGTGVFSKFSVIRTSAEVQQTQTPMKISTSIVESRAQVNNNIKQGIPAVGQIPIVAQPTLVMPQLQETQMMSSTYTSQIKHPPPNASTQVQIATDAGNVSTTPHQQTLAASTSEMSRVPSTITKVQYVLPTLAASYGTSPYACTIQLNVPSTQQKTMVMGQPGVTAIPRSKTPQQQQQQQQKAADKPPDNKVPVRPAGQVLTCRPPATSPAADPNMNMQWMPVGSHALPSTPMLNLRGPSLTPVLPSINLQLVSQAGPQGAVSKGGKAVRITTQPSLTPAGSTIPMVANVTALIPCSTPTTQLTATQVAPVWQFAAASQGVHVASLLMPPVNVKKNPGINTTTVVPQDVPLPNIPLALSSGVPSLPSQTPPGSAATVGGTVNLAAPPRNDTIAAKSAAAGLVQLLSGQPASGAAFPNQFSTTGTGYSRMQVSNHTTDHKQSSRSSAVTIAAAPPTTQSVATGKDDLQSIPGMPGVVCTSASEVKDPSTVTSNCQPSNLPVSQASSRVQTNPAVSMDTATVTQHPDRPHSKDSTTAGQEHKPQLPETSSQTDASSLKILSEVDFEARLAELPEFQPSGTGISRLTTTPRELLSCYRRKRKGSSSMLSKDGEAAPEEPDSPKKSRPRRKSSTSSEPSVGEELANMEMMAEAAVAVQRRGSQSSDGDVFSDVEGDRTSYSSLRRTLDQRRNLVMQLFQEQGLFPSAQATTAFQARYHDIFPSKLCLQLKIREVRQKLMQQQAHGSEGGGEEDSVFHTEDKLQVPLDGTEKNDNGPAAMVASTI
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane.
Sequence:
MSAQRMTRGYLSISPLARGGLQAVTFIMLALPLAGCGTGALWDKFTAKDDTFVEEPADKIYNEGLYLMNEKKDMKAANKKFEEVDRQHPYSDWARKSLLMSAYASYQGGDYDGCIGAATRYVTLHPGSPDAAYAQYLIAASHYDQIPDISRDQSRTEKAIASLEEVIRKYPTSEYATSAKAKIEGARDQLAGKEMNVGRYYMQKRDYTAAINRYKAVVTQYQTTRHVEEALYRLTEAYMAIGIVGEAQTAAAVLGHNFPDSRWYKDAYNLVKSGGLEPSENQGSWISKTFKKMGLG
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MNTTIENNKDNQIEQIEKKVKIQKPKKADFRMHAHVNPLNETLFPYPLNYNQVDWSSHYPKKFGKDPLKLYLNTLEYPITYDDQVKPEYSESIVDFLDIGCGFGGLCFALSENYPDKYTFGMEIRGKVVNFVGEKIRALRDEGQAHDVSVIRTNTMRHLPQYFRKNSLEKIFICFPDPHFKKKNFRRRIVNPGLLSEYAYLLKPSGRIYCITDVEELHNWHVQHLEKHKMFKRVQDVEQDSAAKLIWNSTEEGQKVERNKGSKFIIVCEKV
The following text describes a protein:
Function:
NADH oxidoreductase acting in concert with HCP.
Sequence:
MTMPTNQCPWRMQVHHITQETPDVWTISLICHDYYPYRAGQYALVSVRNSAETLRAYTISSTPGVSEYITLTVRRIDDGVGSQWLTRDVKRGDYLWLSDAMGEFTCDDKAEDKFLLLAAGCGVTPIMSMRRWLAKNRPQADVRVIYNVRTPQDVIFADEWRNYPVTLVAENNVTEGFIAGRLTRELLAGVPDLASRTVMTCGPAPYMDWVEQEVKALGVTRFFKEKFFTPVAEAATSGLKFTKLQPAREFYAPVGTTLLEALESNNVPVVAACRAGVCGCCKTKVVSGEYTVSSTMTLTDAEIAEGYVLACSCHPQGDLVLA
The following text describes a protein:
Function:
Required for normal transcription at a number of loci in yeast. Affects transcription at Ty1 elements, at PHO5, STE6 and ADH2.
Miscellaneous:
MISCELLANEOUS: Present with 1500 molecules/cell in log phase SD medium.
Sequence:
MLNQHTSSVPDDEHLQMAHQNSSSEVRNEAAVPDQLLTPLQPYTILLKDGETIATMYPIPAYPDLLPLGLLNFLLDEFNMEVEKGDSFPYYETLSLEEFKNVWFHNDGHVCIMVLGEIPELDYSMDTEADTNDNFGTEIETTKHTTQYKKRKERRNLNLSMQWEKQCLGIFDLKPAYPGRSAHVVTGTFLVNAGIRGKGIGKTLMETFIEWSKKLGFTSSFFPLIYGTNVGIRRILEGLNFRRIGKLPEAGILKGFDVPVDSFMYGKEFTHITKSIDLLRDPQKSIEIGKYERLKHFLETGKYPLHCDRNEKARLRVLSKTHSVLNGKLMTKGKEIIYDTDQQIQIALEIHLMEHLGINKVTSKIGEKYHWRGIKSTVSEVISRCQKCKMRYKDGTGVIIEQKRAVKQAHMLPTQHIETINNPRKSKKHDNALLGQAINFPQNIISSTLNDVEGEPTPPDTNIVQPTFQNATNSPATTAEANEANKRSEFLSSIQSTPLLDDEQSMNSFNRFVEEENSRKRRKYLDVASNGIVPHLTNNESQDHANPVNRDERDMNHSVPDLDRNDHTIMNDAMLSLEDNVMAALEMVQKEQQQKINHRGEDVTGQQIDLNNSEGNENSVTKIVNNESNTFTEHNSNIYY
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MLPSRFFQTHQENQPSPSKKLKQDHPTLTPSSTQEQEQELPSLSQLIELPSAKKQSQTKTPPSSSSSHHHEAHQQPIQAKTASEQQRPPSKTRLAQFLNTRLADQAQSLPSSDQTKSFQAKIAARASKSIKWEQPQSIWEPGAEQKKPNNGYHPSEKQNCPTVDKDSHDDDEEDDEDEEEEEEEEKPKNKAKLKGKQKNQQTVKLTQLEQQWAEFKKQYPNLVIFMEVGYKIRLFGEDAVLASQVLSIGHLAIPGRETAYFPKTSLYIHMSRMVMAGHKIGLFVQSETRSLRNTELGEKGKKARVFGRHLAGVYSLSTWTESDPNQALGITDSETGLAQNWIVSFHASSPATRHPQREEKVQLSMAAICPQNGEIVWDSWLDDPIRSMLETRMTYLRPVEILVPLSGLDGPSEKLINWLIKDPLARSSVKPRLESTDHDYTPQSAYKLVSNFCQPPKRKSKASMASQDKGNPVSEGDSTEPEFLHHIVELPDGVLIALAGLIVHMKSYQLESIFRQPGQFKSFINQSYMILDANTLKNLEIFENSTDRTERGSLFWVLDRTKTAMGKRILKQWIGKPLVDQRILKERADAIEEIIVSQNHPILIKMRRMLGMRLPDLEKSLVRIQYGKCTEKELLKFLEVMVELTATFGSPSSAGSGKRMFNSSLLQGIFEVFSAVREQTIEYRSELNAKAILKGEYEDMFTNADELYPDLTDLKDCLSCIQAESAEHLQACRITLQNPKLEYVTIGSDEMLIEVRHQQLDRVPENWTKFSSTRAVQRFRTAEGQRLLAERDKYRALIVRRSRGYFEGFLESMEEAYDGFRDAVNRLGLIDCLLSLATVAVENRYARPRIVEHPAIEIRNGRHPIVEQIIDNPLVPNTCSFTQNGLSTMILTGNNMGGKSVTAKMIGCIVLLAQIGSYVPAERAKIGLFDGCYTRMGMSEELAQGRSAFMVEMNEAAKIMRTASPRSLVIIDELGYGTSTYDGLAIANAVLNQLVSSIRCFTIFITHYPQLNELAIKYPERAKSYHMKFLESQGSLKAEEGEGEDDAGWITFLYKLTPGLATKSHGIHVARLAGLPTSILHQARLKSRLLEESVGRKKHTHTASLIKDLLLSLSSSPSSDAGADGQKKTINNGGSEAAAEEMALVSRAETLLSTLCLSSGIE
The following text describes a protein:
Function:
Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGADKLIGFGMLGVAAFVFTYYTAWVFVLPFINEDNILNQFFLPRDYAIKLPILLLFIAALGVGTFVGKVLIKNQQKQKSKKKAQ
The following text describes a protein:
Function:
Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MCGLQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNPPSMRGRALRYINITNCVTSSINVSRAWAVVKSPHIHHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAGRFFQENAFGNPLETTAVLPVQIQLTTSVTLNLEKNSALPNDAASMSGKTSLICTQEVEKLNEAFDILLAFFILACVLIIFLIYKVVQFKQKLKASENSRENRLEYYSFYQSARYNVTASICNTSPNSLESPGLEQIRLHKQIVPENEAQVILFEHSAL
The following text describes a protein:
Function:
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MARTVCGCSWALIFIIMSLLVKAKIDVCKRGDVTVQPSHVISLGSAVNISCSLKPRQGCLQVSSLNKLILYRFHRRIHFQRGHSLSSQVTGLPLGTTLFVCKLACSSKEEIRICGAEISVGVVPEQPQNVSCMQKGERGTVACSWDRGRDTHLYTAYTLQLNGPKNLTWQKQCSDYYCDSLDLGINLPPESPESSYTAQVTAINSLGTASSLPSTFTFLDVVRPLPPWDIRIKCVNASVSTCTLQWRDEGLVLLNRLRYRPVYSRSWNMVNATNAKGRHDLVDLKPFTEYEFQISSKPHLQKGRWSDWSESLRTQTPEKEPTGMLDVWYMKQHIDYKRQQISLFWKNLSLSEARGKILHYQVTLQEVAEGNATLQNITERNSWTWTIPRTGIWAAAVSAANSKGSSLPTRINIADLCGAGLLAPQQVSANPEGSDNLLVKWTSPGEGATAVQEYVVEWRELHLRGGMQPPLSWLRSPPYNTSTLISDNIKPYICYEIRVHALSGDQGGCSSIRGDLKHKAPLSGPHINAISEEKGSILISWDEIPAQEQMGCILHYRIYWKERDSDSQPQLCEIPYRVSPKSHPINSLQPRVTYVLWMTALTAAGESPQGNEREFCLQGKANWSTFVAPSICIAVITVGVFSMRCFRQKVFVLLLALRPQWCSREIPDPANSTWAKKYPIVEEKKQLSLDRLLADWPTPEEPEPLVINEVLPQVTPVFRRPHHPNWPGKGQRLQGRHASEEDTGSSASSPPPPRALTAETGPAVDLYKVLGSRRPDSKPGNPVSHLTVLPVDYLPTHEGYLPSNMDYLPSHEAPITDSLEELPQHISLSVFPSNSLHPLTFSCGEKLALDQLKMGCGSLML
The following text describes a protein:
Function:
Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
Sequence:
MDFLRLYLPGLHQALRGALDSLGTFVSYLLGDAVPTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQARLGRPKPQ
The following text describes a protein:
Function:
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Cell projection, filopodium membrane; Peripheral membrane protein.
Sequence:
MRVLKVEKNEDADQKIEQDGTANKPEDNKAHKAATKIQASFRGHITRKKMKDGEEEKEENSPVADEAKEREEETKKAEGDETPAKQDEAAGEEAKEELNQAKSPAADKPANSPAAAVSPAGAATSPVAPAPSAPTTATAPSEPEKEEPKEKPKEVEAPAATTKSPTTATAEEKKEEEKKWEEKKEEARQADVPAAVSPTAEEEPNQTKDQQGMPITALQLSLGHMTGMGATVFLVIRAHRGS
The following text describes a protein:
Function:
[Gasdermin-A3]: Precursor of a pore-forming protein involved in the transition from catagen to telogen at the end of hair follicle morphogenesis. This form constitutes the precursor of the pore: upon cleavage, the released N-terminal moiety (Gasdermin-A3, N-terminal) binds to membranes and forms pores, triggering pyroptosis. This form acts as a sensor of infection: activation is triggered by cleavage by some bacterial effector protein, which releases the N-terminal moiety (Gasdermin-A3, N-terminal) (By similarity); [Gasdermin-A3, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage by some bacterial effector protein, and binds to membrane inner leaflet lipids (By similarity). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis. Binds to membrane inner leaflet lipids, including bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to monophosphorylated phosphatidylinositols. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity. Plays a role in the transition from catagen to telogen at the end of hair follicle morphogenesis, possibly by regulating hair follicle stem cell niche maintenance. Also required for mammary gland development.
Subcellular Localization:
[Gasdermin-A3]: Cytoplasm, cytosol; [Gasdermin-A3, N-terminal]: Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Domain:
Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain; [Gasdermin-A3, N-terminal]: Forms a ring-shaped pore complex containing 27-28 subunits that inserts into the membrane. The pore conduit is predominantly negatively charged, facilitating the release of mature interleukin-1 (IL1B and IL18). In contrast interleukin-1 precursors are not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation.
Sequence:
MPVFEDVTRALVRELNPRGDLTPLDSLIDFKHFRPFCLVLRKRKSTLFWGARYVRTDYTLLDLLEPGSSPSDLTDSGNFSFKNMLDVQVQGLVEVPKTVKVKGTAGLSQSSTLEVQTLSVAPSALENLKKERKLSADHSFLNEMRYHEKNLYVVMEAVEAKQEVTVEQTGNANAIFSLPSLALLGLQGSLNNNKAVTIPKGCVLAYRVRLLRVFLFNLWDIPYICNDSMQTFPKIRRVPCSAFISPTQMISEEPEEEKLIGEMHEDFKTLKEEVQRETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQKLEGALDKGQKVTLEALPKDVLLSKDAMDAILYFLGALTELTEEQLKILVKSLEKKILPVQLKLVESTLEQNFLQDKEGVFPLQPDLLSSLGEEELTLTEALVGLSGLEVQRSGPQYAWDPDTRHNLCALYAGLSLLHLLSRKSNALTYCALS
The following text describes a protein:
Function:
Required for radial migration of cortical neurons in the superficial layer of the neocortex. Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MEVTCLLLLALIPFHCRGQGVYAPAQAQIMHAGQACVVKEDNISERVYTIREGDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYSCQVSVRNVCGIPDKAVSFQLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCVASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRQREAQVQLNVQFPPEVEPGSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPAVPVAAEAPDHSELRLDAVTRESSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSVRQLNQHNALVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPISSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRSKGALDTHAWSLSGNKGNVWQQAHVPINPSGPFQIIFEGVRGSGYLGDIAIDDVTLKKGECPRKQMDPNKVVVMPGSGAPRQPLPQLWGPVATFLLALQR
The following text describes a protein:
Function:
Cysteine protease that plays an important role in the inhibition of host innate immune response. Cleaves host elastins found in connective tissues, pulmonary surfactant protein A in the lungs, and the chemokine receptor CXCR2 on leukocytes. Proteolytic cleavage of surfactant protein A impairs bacterial phagocytosis by neutrophils while CXCR2 degradation blocks neutrophil activation and chemotaxis. Additionally, promotes vascular leakage by activating the plasma kallikerin/kinin system, resulting in hypotension.
Miscellaneous:
MISCELLANEOUS: The catalytic maturation of ScpA appears to reside outside the cascade of activation started by the metalloprotease aureolysin (aur).
Subcellular Localization:
Secreted.
Sequence:
MKRNFPKLIALSLIFSLSVTPIANAESNSNIKAKDKKHVQVNVEDKSVPTDVRNLAQKDYLSYVTSLDKIYNKEKASYTLGEPFKIYKFNKKSDGNYYFPVLNTEGNIDYIVTISPKITKYSSSSSKYTINVSPFLSKVLNQYKDQQITILTNSKGYYVVTQNHKAKLVLKTPRLEDKKLKKTESIPTGNNVTQLKQKASVTMPTSQFKSNNYTYNEQYINKLENFKIRETQGNNGWCAGYTMSELLNATYNTNKYHAEAVMRFLHPNLQGQRFQFTGLTPREMIYFGQTQGRSPQLLNRMTTYNEVDNLTKNNKGIAVLGSRVESRNGMHAGHAMAVVGNAKLDNGQEVIIIWNPWDNGFMTQDAKNNVIPVSNGDHYRWYSSIYGY