lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
Sequence:
MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGRVTKICFCGGHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE
The following text describes a protein:
Function:
Part of the ammonia monooxygenase complex, which catalyzes the oxidation of ammonia to hydroxylamine, the first reaction in the process of ammonia oxidation to nitrite.
Miscellaneous:
MISCELLANEOUS: The physiological significance of the two gene copies is still unknown.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Ammonia monooxygenase is active and distributed approximately equally in both subcellular fractions.
Sequence:
MSIFRTEEILKAAKMPPEAVHMSRLIDAVYFPILIILLVGTYHMHFMLLAGDWDFWMDWKDRQWWPVVTPIVGITYCSAIMYYLWVNYRQPFGATLCVVCLLIGEWLTRYWGFYWWSHYPINFVTPGIMLPGALMLDFTLYLTRNWLVTALVGGGFFGLLFYPGNWPIFGPTHLPIVVEGTLLSMADYMGHLYVRTGTPEYVRHIEQGSLRTFGGHTTVIAAFFSAFVSMLMFTVWWYLGKVYCTAFFYVKGKRGRIVHRNDVTAFGEEGFPEGIK
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MDSVAQRLSAVGAGAALELRGVTRLFGALAALTDVTITVRPGERRAVLGSNGAGKTTLFNCITGDFPPSSGTIRFFGEDVTHFPPYERIRRGLRRTYQISALFPGLTVQDNVYLACRGISRGRFSFLRPGQNDALMHAADNLVQAVHLTAVKDQRVAELAHGQQRQLEIALALAGAPRFVLFDEPAAGLSPTERQELIEILTSLPAHIGYIIIEHDMDVALRVVESVTMMHNGRVFKEGLPQEIESDPEVQELYLGGGHE
The following text describes a protein:
Function:
Collagen VI acts as a cell-binding protein.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
METWKIFWGIILFETGFGFIKSQSIVCREASLGDVVFLVDANINPQHARSVRNFLYILVNSFNVSSKTIRVGLAQYSDVPHSEFLLSTYHRKADVLRHIRQFKFKPGGKKMGLALKFILDHHFQEASGSRASQGVPQIAMVISSGPVEDHVHGPAEALRRAGILLYATGVRDAVWAELREIASSPQENFTSFVPYFSGLSNLAQKLRQELCDMLAKAAPRVDHVSPACREAALADIVFLVDSSTSIGPQNFQKVKNFLYSVVLGLDISSDHVRVGLAQYNDNIYPAFQLNQHPLKSTVLEQIQNLPYRTGGTNTGSALEFIRTNYLTEESGSRAKDRVPQIVILVTDGESNDEVQEVADRLKEDGVVVYVVGVNVQDVQELQKIASEPFEKFLFNTENFNILQDFSGSILQTLCSAVEGKIKEFIKAYADVVFLADTSQDTSWASFQRMQNFLSRVVGMLEVGRDKYQIGLAQYGDQGHTEFLLNTYKNQKEMIAHIHERFVPLGGSRRTGKALQYLLQTFFQEEAGSRYLQGIPQYAVVINSGKSKDEVQDAAQRLREKGVKVMSVGVQDFDRRELEGMGSPDLVYDMQREDEVRHIVEDVNVVIQGTGQQQHRITANEEAVGACTTAIRADLVFLIEEFSRVRQPNFQQVVNFLKTIVSSLSIHPDTVRFGLVFYSEEPRLEFSLDTFQNPAKILEHLDKLTYRERRGRTKTGAALDFLRNEVFIQEKGSRSNHGVQQIAVVIMEGFSQDSVSRPASHLRRAGITIYAVGTQNVSESKELEKIASYPHWKYSVPLESFLQLSVVRSKLINQLCSEMVDSKVSFRGMSYPLQEGCVHVEKADIYFLIDGSGSINPQDFLEMKAFIKEVIKMFQIGPNRVQFGVIQYSDKIQSQFILSQYPSVAELKVAIDNIQQGGGGTATGEALNNMTQVFADTGRINVARYLIVITDGKSSDPVAEAAEGLRENGVIIYAIGVREANIDELKEIAKDKIFFVYEFDLLKDIQKEVVQDICSSEACKTSKADIIFLIDGSESISPEDFEKMKRFVASMVNQSNIGTDGIQIGLLQFSSIPQEEFRLNQYSSKVDIYSAIFDVQQMRDGTRTGKALNFTLPFFDSSKGGRPSVQQYLIVITDGVAQDNVIIPAKALRDKNIIIFAIGVGEAKKSQLLEITNDEDKVYHDVNFEALQNLEKEILSKVCDPQGCNLDLSVGIDISTHSKQVQQKLQGLLPELMQQLTLLSNISCGIPDQINPRFRYLVPGSNGKLIFDSGFEKYSYEIIQKFLVHQAAKNNNMDVNFLQSLGDNAIHLSSAKVKVLLVFTDGLDDDLKRLKKTSEFLHSRGFSGLLIIGLEGVHKLEELQELEFGRGFAYKQPLSITLQSLPSVLLKQLDTIVERTCCNIYAKCFGEDGYRGDYGSSGRKGEKGFDGLPGHPGEEGRYGERGPQGLPGLRGEEGCPGMRGPKGARGFSGEKGNPGEEGVDGLDGEQGNRGIPGSSGEKGNRGNRGLTGPPGQPGERGEPGLRGDPGDPGTNSYVQGPKGEKGRRGHQGSSNFDGPQGEPGNVGPWGTIGRRGLPGLKGVPGESGEQGYQGELGYPGSQGSRGRQGPPGTSGQKGLVGAQGNPGPPGPKGSKGKAGPRGVKGELGDVGERGPQGRQGPRGQPGLPGSDGYGHPGRKGTKGERGFPGYPGVQGEDGDLGHQGEKGAKGVRGKRGNAGFPGLVGTLGYQGPPGQMGIKGPKGLVEMTPCKIVDFTRENCPCSRGISKCPVFPTEVAFALDMSNDVSPLDFERMRNILLSLLMKIEISDSNCPTGARVAIVSYSAKTNYLVRFSDYKEKAALLEAVRNIPLEHSSGRRNLGATMRFLARHVFKRVRSGLLMRKVAVFFQVGWAYDAASINTATLELAAADIIPAVITFTKGHNLPDTLLMDGTNRFYLFIWETEHQQDVEHVARCILCYDKCRPDPECPAGAPGPQEMDVDLVFLVDSSYGVDADVYRGSLSLVDATLEDLEVAEQPSASHGGARVALVMHTTPNFWPGVGRRPVLEGFRLTTFSNRKQMQRLVHEAAAHPLQGTPALGHALEWTLENVLLAAPLPRRAQVLFAIVASETSSWDREKLWTLSLEAKCKGITLFVLALGPGVGTHELAELAELVSAPSEQHLLRLQGVSEPEVNYARGFTRAFLTLLKSGTNQYPPPELTEECGGLHRGDTLLQLVTPVNRLPRHQFGMSGLADDLEALEATGIFLEEKRKDMTTSITQQEVLENYENNKYDIEENEQETPAKQKETGKEINAGTTYGPCSMDPIEGECQDHTLKWYYNKEERVCQQFWYGSCGGNANRFETKEECEAQCVPIQ
The following text describes a protein:
Function:
Enzyme which catalyzes the acetylation of polyamines. Displays higher substrate specificity for spermine than for spermidine. May function to acetylate host-derived polyamines, thus alleviating the necessity for de novo synthesis of these molecules.
Subcellular Localization:
Cytoplasm.
Sequence:
MISSFEVRKATIDDYFELRNLICDVTRCTETLSREQAEERFRYNTYHPYCLVDTENGRIVGYAGFYIIPHLGRKNDSRIEHVIISKEYRNRGLGRLLCKQIIEDAKNKFNCGRIDLTVESHIAKKLYSSLEFEKVNTEVMRNSFLDLTPKSD
The following text describes a protein:
Function:
Acts as a membrane-bound chaperone in endoplasmic reticulum quality control. Probably facilitates presentation of substrate to membrane-bound components of the degradation machinery (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MKLFLYHFTFIVYYFIISFSYAFSIKQEIIVSSHNASSILNTTAFWFVEFTESKYDKEEFSVIWNEVSMEFPDIRRAKVFCDLDLEFCAQQEIYDHPKVVVLKNGMWMRHVLEKNQITTKSARQFVKSHLGNCDLEQAENETDCFSDDGEYNSDSSSTDPAFELKEDQSWKHSSILRPLETLNFKRFLFGNEIMSKTRAFVMFVSLKHCEDCFHWEAVWSSITRNTDERLKMAQVNCDEEKEMCNHFHIKKFPTFRVFQGFDSIQYNGPLKYQQLLSYSNQVASYQAIKIEEGDIESIENSHPVFFLVLYDFATTSEDFSIIERLKLQLAGVAPLYICNSKALANKYGAQSQPSIIAVRNGMPIVYQAITPREFRDYKRITEWINIVSSPFITELTPTKCHSLLNRKLTVLTLLQPDSEQFFSSQEELLRLGKRWFRFQMQRQRNDIVWSRIKKYSAIAEAKKKGFARKVKRIKYSKISHPTYTESVSFLWLDSSLWLDWIVENLDHTVYVDSITPPVFVIDHSKGVIYVSDRNGNSLTLEEDSLFSTLRIILEHPNSSRLQKLRAPGLCPNGSPNYRNRYKLIVFNLLIALLILSILTIISASRLSRRRRQLLNKQPVFGFYHSLVIAKSD
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSSRLGAVPATSGPTTFKQQRSTRIVGAKNSRTQCSIKDNSFQYTIPHDDSLSGSSSASSCEPVSDFPASFRKSTYWMKMRRIKPAATSHVEGSGGVSAKGKRKPRQEEDEDYREFPQKKHKLYGRKQRPKTQPNPKSQARRIRKEPPVYAAGSLEEQWYLEIVDKGSVSCPTCQAVGRKTIEGLKKHMENCKQEMFTCHHCGKQLRSLAGMKYHVMANHNSLPILKAGDEIDEPSERERLRTVLKRLGKLRCMRESCSSSFTSIMGYLYHVRKCGKGAAELEKMTLKCHHCGKPYRSKAGLAYHLRSEHGPISFFPESGQPECLKEMNLESKSGGRVQRRSAKIAVYHLQELASAELAKEWPKRKVLQDLVPDDRKLKYTRPGLPTFSQEVLHKWKTDIKKYHRIQCPNQGCEAVYSSVSGLKAHLGSCTLGNFVAGKYKCLLCQKEFVSESGVKYHINSVHAEDWFVVNPTTTKSFEKLMKIKQRQQEEEKRRQQHRSRRSLRRRQQPGIELPETELSLRVGKDQRRNNEELVVSASCKEPEQEPVPAQFQKVKPPKTNHKRGRK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MVNLLQIVRDHWVHVLVPMGFVIGCYLDRKSDERLTAFRNKSMLFKRELQPSEEVTWK
The following text describes a protein:
Function:
Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MWNPSAGPNPYPPQVVCPGGSNPACPPSQNPAFPPGPCPPGIPQGNPAFPPCRPPYPVPQPGCPGYQPSGPYPPPYPPAAPGMCPVNPPAPGMVGPGIVIDKKTRKKMKKAHKKSHKHHKHGKHSSSSSSSSSSSSDSD
The following text describes a protein:
Function:
May be required for sperm motility and function.
Sequence:
MEEEGGGRSCGTTRELQKLKQQAMEYYRENDVPRRLEELLNSTFYLQPADVYGHLANCFSKLAKPPTICKIVGKDVLDGLGLPTLQVDIFCTIQNFPKNVCSVVISTHFEVHENALPELAKAEEAERASAVSTAVQWVNSTITHELQGMAPSDQAEVDHLLRIFFASKVQEDKGRKELEKSLEYSTVPTPLPPVPPPPPPPPPTKKKGQKPGRKDTITEKPIAPAEPVEPVLSGSMAIGAVSLAVAKACAMLLNKPLYLNIALLKHNQEQPTTLSMPLLMVSLVSCGKSSSGKLNLMKEVICIPHPELTTKQGVEMLMEMQKHINKIIEMPSPPKAETKKGHDGSKRGQQQITGKMSHLGCLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYNKGKYEVIMGTYKNAAEMVDLYVDLINKYPSIIALIDPFRKEDSEQWDSIYHALGSRCYIIAGTASKSISKLLEQGNISIPKSNGLIIKHTNQTTMSDLVEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLGVRFIKLGGLSRGERVTKYNRLLTIEEELVQNGTLGFKEEHTFFYFNEEAEKAAEALEAAAAREPLVPTFPTQGVEESAETGASSG
The following text describes a protein:
Function:
Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine. The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site.
Sequence:
MGTSEAAQPPFARVAPALFIGNARAAGATELLVRAGITLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLTHLEPTCAAMEAAVRDGGSCLVYCKNGRSRSAAVCTAYLMRHRGHSLDCAFQMVKSARPVAEPNLGFWAQLQKYEQTLQAQAILPQEPTDPE
The following text describes a protein:
Function:
Contributes to cell wall structure in root hairs and seeds, especially in phosphate (Pi) deprivation conditions or in the presence of ethylene. Particularly important in maternal tissues (pericarps and seed coats) during seed development, especially under stress conditions. Confers thermotolerance in seed germination rate.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MAFSRLSFAASLIVFSSLIISSVAYYGNEADPETGKLIPIAVEGIIKCKSGGKTYPIQGATARIACVKVDAYGNELVPISILSSKTDAKGYFIATIFPSQLRAGRTVTKCKTYLYKSPLADCDFPTDVNKGVRGQPLSTYRILQDKSFKLYWAGPFFYTSEPTYY
The following text describes a protein:
Function:
Chromatin reader component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). Component of the ADA histone acetyltransferase complex, which preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B. SGF29 is also required for heterochromatin boundary formation function, prevention of the spread of gene silencing at the HMR locus.
Miscellaneous:
MISCELLANEOUS: Present with 1750 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me).
Sequence:
MDGYWDVVVSSLQDIYNANEVIPFDDELQTKKLNFLNMSKDQLQLHLNTFQEHMENVNRVHRILDNVRSNLSLMLNQSREEKSEENTEDAEEGEGTRMALSQGKKAVGKVGRSYWTSEYNPNAPILVGSEVAYKPRRGSADGEWIQCEVLKVVADGTRFEVRDPEPDELGNSGKVYKCNRKELLLIPPGFPTKNYPPGTKVLARYPETTTFYPAIVIGTKRDGTCRLRFDGEEEVDKETEVTRRLVLPSPTALANLARK
The following text describes a protein:
Function:
Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKGGLEELSLAQT
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Sequence:
MDRLEVNIIPEVNEIYVYMKGVPLLGDETFDNVIKKFHPTNLYSSYCYVEIADGQRFWSQEFHNATPVATKCFNLCDNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYANFFLDRAKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITKQITTYIKKEVLKKKHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLKFFPGSMLNDVQKSQILDNLLPRIPFKHRTHVDAKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRKLFKKKEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFPIIKASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGLSSAQEVREYFQDLGKHRAYFVWDDKDETSIKLAFSKKAEEWEAWIGNSQPGTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITARGLIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEILKKGKSAEPHVAGAIDYSSKEQEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFDVM
The following text describes a protein:
Function:
Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
Subcellular Localization:
Periplasm.
Sequence:
MRLVLSSLIVIAGLLSSQATAATAPEQTASADIRDSGFVYCVSGQVNTFNPQKASSGLIVDTLAAQLYDRLLDVDPYTYRLVPELAESWEVLDNGATYRFHLRRDVSFQKTAWFTPTRKLNADDVVFTFQRIFDRRHPWHNINGSSFPYFDSLQFADNVKSVRKLDNNTVEFRLTQPDASFLWHLATHYASVMSAEYAAQLSRKDRQELLDRQPVGTGPFQLSEYRAGQFIRLQRHDGFWRGKPLMPQVVVDLGSGGTGRLSKLLTGECDVLAWPAASQLTILRDDPRLRLTLRPGMNIAYLAFNTDKPPLNNPAVRHALALSINNQRLMQSIYYGTAETAASILPRASWAYDNDAKITEYNPQKSREQLKALGIENLTLHLWVPTSSQAWNPSPLKTAELIQADMAQVGVKVVIVPVEGRFQEARLMDMNHDLTLSGWATDSNDPDSFFRPLLSCAAINSQTNFAHWCNPEFDSVLRKALSSQQLASRIEAYEEAQNILEKELPILPLASSLRLQAYRYDIKGLVLSPFGNASFAGVSREKHEEVKKP
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTIFLGVYKAVYAYEPQNEEELALEEDELLYLLQKSEVDDWWTVKKRVLGGDMDEPVGLVPNNYIEEAPVVGRVRAVYDYEEAQNPDEELVFREGDEFDVYDDRDADWVLVRKRADGSVGFAPGNYVEKVGAAPAGERAPARAPALAAAAAPVLTTAAAVRERPLQEQQPRRIASGSSERDDRPLPRLPVRTDYSEDEEAPPPKPARPEQHSAASAGSQPSWAREEAADSIMDISGSWDVQEIDGRRKKKAKLQVGRETVLFCPADGDIKSWPISHLISYDNEKKHIFLEFKDPYCNLELHVGTNSTAIEIKSLLAEMKATVNPGALREIEAASVAPKKRGIIKYNFFGESSDELTVKEGDVVYILNDKKSADWWMCEIIGTSRQGVIPAQFIDVQPTEARKSLTATIAGLKDGSSASSQKGSQLGDWKQDVDQDSSERRKSMSKKKEDKKSKKKKFPDPKNTRIWVDRSNTFKVEAEFLGFVDGKIHLHKVNGVKIAVAAEKLSMDDLAYVEKVTGTSLNKYRPEVKAPPVSKRNDEQDQRRQLRQHEDREREREERERDRRLRERELEELRKARDLLDEERAKLQSMKENSSQRPRSSGSEQDYDWFEFFLNCGVDVSNCQRYTLKFEKEHISKEILPDLCPPILRTLDMREGDIIRVMKYLDNHYGRTSQSSSSPPADSNNANVQTGHGLSEQLLPIQTSTKDDDAWTVKPAANTESSLPHSKKEFSGSFQDLLDLKPLEPKKKEETPQPNLKDLESVKTGGSAKAAAPVPQATAAPLDPFKTGGNNLLPTATGGVLLMPVLTGGLMPLQTTGGLIPLQRTGGFVMPQTTFGQPTGNILPVQKTANGLIPVGGGLVPQTTFGVAPLNASFTGGNIAFQRTGGMATGMVPQTSFAGPMNPVMTGGMVPLQRTGGFMPNMMPQTSFSTNPMNQISTGMMSSQLTGGMAMAGPQTSFGMPAMNQTFTGGVPGVMPQTSFGMAQMNPGSSSGMIPLQRTGGMPGVLPQNSFGNAPINQALTGGLSMGTLPMQTTFGAPQQMTGFQQNPMMGMQNTSGMTSFPNTSFGTANINQLSNNMQGMSLNQQQVPLQNQPTGFGFGNGPQQQKQANIYNASAANPFGF
The following text describes a protein:
Function:
N-acetylglutamate synthase involved in arginine biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRSSRITAGTCVSRGWHSYTTKTPTKTAIPPAAKSSNEAKDLILSVLQSAATKREAKTYISRYAPLTGVELQKKKEGLVQRLLGVGKEQDNKEIENLTGHAPEGLLGDSEGTLRVAIIKIRDIKSIEDDLIAQMGETIARLSRLGVSPIVVVDAGKARNDFLKLDNKPFRHYQKLILQKVFKISDAIDAASPDVGARPIEGLFSMNKKGLRLAMPQMLMHPLSHGKVPVLAPLAYDDVTSEEKLVMADDVVHFLTQKLAEVPANILSVEKIIFVDPLGGIPSVERSGAHVFVNLKQELSDIAAELHMGFIPPAQREVHLANLKAMHKALKFLPPTASGLITTPAVAAIPSVGRNPIIYNVLTDRPVISPSLPVELKKTPTLETTLLREGMPVITLKSDKGLNLITEHEKGNIDLDRLWHLIEDSFGRRIDKQHYLNRVNGKIAGIIIAGDYEGAAIITWEDIDPVKAQEDRDAADRAAAEAAAAYAAGIPLPSPPLYQKLGDAVPLNPNQVAYLDKFAVLKRSQGSSSVADVVFKGMVMSQFPNELLWRSRKNNPVNKWYFDRSKGSFKIPGSEWCMFWTGRKTREQYLERFVDICTRIEPSLREEL
The following text describes a protein:
Function:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MILLETNNRVVEETLTVKIKSAQAGLKNESIDITVSDFDGVLYHISNLNGDKTKIRISISLKFYKELQEHGADQLLKREYGPLLAAPEDGYNVSILFDLENIPTDWPQVIKKIGLLKRNCFASVFEKYFDFQENGDEGQKRAVIHYRDDETMYVEAKADRVTVVFSTRFRDEDDVVIGKVFMQELKEGLRASHTAPPVLFSHREPPRELQNTDAKVDNNVGYVTFVLFPRHTARTTRDNTIDLIHMFRHYLHYHIKCSKAYIHSRMRAKTSDFLKVLNRARPENKSTDKKTITYRNCFASVFEKYFDFQENGDEGQKRAVIHYRDDETMYVEAKADRVTVVFSTRFRDEDDVVIGKVFMQELKEGLRASHTAPPVLFSHREPPRELQNTDAKVDNNVGYVTFVLFPRHTARTTRDNTIDLIHMFRHYLHYHIKCSKAYIHSRMRAKTSDFLKVLNRARPENKSTDKKTITGRTFVRRD
The following text describes a protein:
Function:
Ring-cleaving dioxygenase involved in quinaldine degradation and utilization.
Sequence:
MTDTYLHETLVFDNKLSYIDNQRDTDGPAILLLPGWCHDHRVYKYLIQELDADFRVIVPNWRGHGLSPCEVPDFGYQEQVKDALEILDQLGVETFLPVSHSHGGWVLVELLEQAGPERAPRGIIMDWLMWAPKPDFAKSLTLLKDPERWREGTHGLFDVWLDGHDEKRVRHHLLEEMADYGYDCWGRSGRVIEDAYGRNGSPMQMMANLTKTRPIRHIFSQPTEPEYEKINSDFAEQHPWFSYAKLGGPTHFPAIDVPDRAAVHIREFATAIRQGQ
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for separation of the spindle poles during mitotic spindle formation. May cross-link overlapping antiparallel microtubules in the spindle midzone.
Miscellaneous:
MISCELLANEOUS: Present with 521 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Localizes to kinetochore microtubules and to the overlapping microtubules of the spindle midzone.
Sequence:
MSSFNNETNNNSNTNTHPDDSFPLYTVFKDESVPIEEKMALLTRFKGHVKKELVNESSIQAYFAALLFISGHYAYRSYPRLIFLSHSSLCYLIKRVAMQSPVQFNDTLVEQLLNHLIFELPNEKKFWLASIKAIEAIYLVNPSKIQAILANFLRRPSENQNGDYLNRIKSTLLTIDELIQINEKNNSNHLQLLRFFMLSFTNLLNNNLNEHANDDNNNVIIELIFDIMYKYLKMDDENSQDLIDGFINDLEVEKFKQKFISLAKSQDQHGSQEDKSTLFDEEYEFQLLLAEAKLPQLSNNLSSKDPAMKKNYESLNQLQQDLENLLAPFQSVKETEQNWKLRQSNIIELDNIISGNIPKDNPEEFVTVIKEVQLIELISRATSSLRTTLSLTALLFLKRLIHILNDQLPLSILDQIFVIFKNLLSSTKKISSQTAFHCLITLIIDINHFHNKLFQLSFLLINEKTVTPRFCSAILLRSFLIKFNDSNLSLNNSNTTSPTSKLENNIIYIEEWLKKGISDSQTTVREAMRLTFWYFYKCYPTNAKRLLSSSFSPQLKKATELAIPAHLNINYQVSRVSSTASASSATSRLYSHSSNNSSRKTSLLEQKRNYPSYAQPTQSSSTSLLNAPAVTAGGSVIASKLSNKLKTNLRSTSEYSSKENEKRARHHDSMNSVSNSNTKDNNNVTKRKVSAPPSSTAATKVSENYTNFDDFPSNQIDLTDELSNSYSNPLIKKYMDKNDVSMSSSPISLKGSNKLGEYETLYKKFNDASFPAQIKDALQYLQKELLLTSQQSSSAPKFEFPMIMKKLRQIMIKSPNDFKPFLSIEKFTNGVPLNYLIELYSINSFDYAEILKNRMNPEKPYELTNLIITIADLFNFLNANNCPNDFKLYYMKYKTTFFNYNFKLLLEIFRNLNIKHDNTLRSGTNDLMPKISMILFQIYGKEFDYTCYFNLIFEIYKFDNNRFNKLLADFDIVSTKMKICHELEKKDANFKVEDIISRESSVSFTPIDNKKSEGDEESDDAVDENDVKKCMEMTMINPFKNLETDKTLELKNNVGKRTSSTDSVVIHDDNDKDKKLSEMTKIVSVYQLDQPNPAKEEDDIDMENSQKSDLNLSEIFQNSGENTERKLKDDNEPTVKFSTDPPKIINEPEKLIGNGNENEKPDLETMSPIKINGDENMGQKQRITVKRERDVALTEQDINSKKMKLVNNKKSEKMHLLIMDNFPRDSLTVYEISHLLMVDSNGNTLMDFDVYFNHMSKAINRIKSGSFTMKHINYLIEPLITCFQNQKMTDWLTNENGFDELLDVAIMLLKSTDDTPSIPSKISSKSIILVHCLLVWKKFLNTLSENADDDGVSVRMCFEEVWEQILLMLNKFSDYGNEIYKLAQEFRDSLMLSHFFKKHSATRILSMLVTEIQPDTAGVKETFLIETLWKMLQSPTICQQFKKSNISEIIQTMSYFIMGTDNTSWNFTSAVVLARCLRVLQTTPDYTEQETERLFDCLPKNVFKMIMFIASNE
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSFRGRGGGGGGRGGGGFRGGRGGDRGGRGGRGGFGGGGRFDQGPPEEVIEVGIFTHTCEDDIVCNTTCGKIPYFNAPIYFDNKEQLGKVDEIFGGPKNNGFSVKLSDGIKASSFKENQKMYIDPAKLLPVERFLPQAPGSRGRGRGRGGDRGGRGGRGGFGDRGGRGAFGGGRGGGFGGDRGRGGGRGGFGDRGGRGGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGFKRSFDGGSGGAGKRTKFDD
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular Localization:
Nucleus.
Sequence:
MENYEEVGDLTDIVRGRSSTTTTRSSTTTTTTTTSSSSNCKTEILADHHLQDSTSFYYSSSSQLLQLQDHQHHQYNFGDPFCSVVAPSVLDHHLHQHHHQLPVDNSTNINAFFNGISASSTTTTAAAAHQDHEDHHEVMKSSPCNSNLFSRMLQISPSPNKFQTISSLTNNSPPPSNFLISNHSPTTTTTPLHPDHHLHHFLHHHDHNNNNNNNTSSALHISSPRNPPGIKRRKSQARKVVCVPAPVAASSRPNGEVIPSDLWAWRKYGQKPIKGSPYPRGYYRCSSSKGCSARKQVERSRTDPNMLVITYTSEHNHPWPTQRNALAGSSRSSQQSSKNNTSTITTTSTTTQPNSSKLVHHKNKQEVQEEEEEQDHENNNDGTTMTLLSSTAAVDEEASNKNNNNVKEEEMIENELMMSSTSEGGLIDEDHDFFADLEELETDPLTLLFNTTTQQQQQQQQHLQQPPHKLEQIIKGSAAAACLHDVVPFNHLFDWPPPPHQEQPPPSSPTNRGFY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATACKRSPGEPHSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEVCTNEFCASCPTFLRLDNNAAAVKALELYKINAKLCDPHPSKKGASSAYLETNSQGTPNKSCPERRMNRKEAHGPRDDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKAKQHTKEELKSLQGKDEDKDEDEKEKAACSAVAMEEDPEASSSRPGESSQGNNDRHRPGPDEVSVDVEAVRRIYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENGNLHSPEYLEMALPLFCKAMSKLPLAAQAKLIRLWSRYSADQIRRMMETFQQLITYKVISNEFSSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTDHNEEEDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRRPLIPFEEFVNEPLNDILEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYEESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLADSHPVLYQSLKDLLEYEGSVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYARDSLIIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASRLLARSKALALALSRADAAAPGPAAGVQWLRTLSSLPRDPAAAASPAPAPRQPAVGSPLGLSKIPGYEQTSRLSGTQVLPRWFSTGTSNGSSAQQEGATRKVMAFSPLEASIAKPRKGPLTSESWKVKQTELLTRSTYYMIPTLLLVSKNSISTSLLVASVFHQVYMFYKEILLDYVHHDITRKWVFIYFKILLIIMAKETVVYFDLF