lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the negative regulation of dendrite outgrowth.
Subcellular Localization:
Cytoplasm.
Sequence:
MLANAATMRILIKGGKVVNDDCTLEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCIDDFYHGTKAALVGGTTMVIGHVLPDKDISLLDAYEKCRSLADPKVCCDYSLHMGITWWAPKVKSEMETLVREKGVNSFQMFMTYKDSYMLRDSELYQVFRACKDIGAIARVHAENGELVAEGAREALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPVYLVNVSSMSAGDVIATAKMQGKVVYAETTTAHSTLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTINVVASDHRAFTTKQKAMGKEDFTKIPHGVSGVQDRMAVIWERGVVGGKMDENRFVAITSSNAAKIHNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDINLYENMRCHGVPLVTISHGRVVYENGVFMCAEGTGKFCPLRSFPDSVYKKLVQREKSLKLKSVDRTPYLGDVAVVVHAGKKETGTPLADTPTRPATRHGGMRDLHESGFSLSGSQIDDHVPKRASARILAPPGGRSSGIW
The following text describes a protein:
Function:
Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.
Subcellular Localization:
Nucleus.
Sequence:
METVSGNHVSVVKKRTFSEMLDESCVDEGRKSYSPQSHRVCSSGKEAASGGKGDGVGADDLEPREENTWSDSKRNRRIRTTFNPEQLRELENVFQVTHYPDVKTRDELSSKTSLPEQRIQIWFQNRRAKWRKFERLGNFGGLEELKNTEIVPAPRSVPRLDLAKRDPSIGSTAPLSSPDRPPVTSSLIHPYNVPSFPSPLNVASQTCFQPPARYYPMMPPPHAFHPDPNILAFRQAHLAHPEYVQPSVSKLYQNDFAIVWPERKSETIASDDCRRSDSSVSDLRMKAKEYEAAVGMQYMAYPHLYWNSPYLFHHR
The following text describes a protein:
Function:
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Subcellular Localization:
Nucleus.
Sequence:
MTPPPPPPPPPGPDPAADPAADPCPWPGSLVVLFGATAGALGRDLGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSTQCREASGLSADSLARAEPLDKVLQQFSQLVNGDVALLGGGPYMLCTDGQQLLRQVLHPEASRKNLVLPDMFFSFYDLRREFHMQHPSTCPARDLTVATMAQGLGLETDATEDDFGVWEVKTMVAVILHLLKEPSSQLFSKPEVIKQKYETGPCSDSTVPCPYSSKADVVDSETVVRARGLPWQSSDQDVARFFKGLNVARGGVALCLNAQGRRNGEALIRFVDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGTSLEVARFLSREDQVILRLRGLPFSAGPTDVLGFLGPECPVTGGTEGLLFVRHPDGRPTGDAFALFACEELAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYASGPLLPTLTAPLLPIPFPLAPGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPSGDAFIQMTSAERALAAAQRCHKKVMKERYVEVVPCSTEEMSRVLMGGTLGRSGMSPPPCKLPCLSPPTYTTFQATPTLIPTETAALYPSSALLPAARVPAAPTPVAYYPGPATQLYLNYTAYYPSPPVSPTTVGYLTTPTAALASAPTSVLSQSGALVRMQGVPYTAGMKDLLSVFQAYQLPADDYTSLMPVGDPPRTVLQAPKEWVCL
The following text describes a protein:
Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Sequence:
MMQHWLSADWPVSQICALIGQVTRSTRPLSPKTSGCRGKSSELFPRFSWWFLPTTLVFSDHKFVLLAIMAPSTSDPGGEQTDLWVFGYGSLTWNTCFPYTERVVGSVPGFSRRFWQANTVHRGTPDQAVTWGVAYQLKGRGQVTRALQHLTIREGALGGYTTEVARFIPADESLPSRDVLVYLSTEENPLYLGHSTQQETAVAIAAAVGRCGHNAEYLFKLSRFMRTSVPMVTDDYLFGLEAMVKNLLGQERAQELETSQTVADELSLTCRKDSVPMPCRFEYLPCRTVAECQRIETRPASESG
The following text describes a protein:
Function:
Acylhydrolase that catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position. Has a strong galactolipase activity toward digalactosyldiacylglycerol (DGDG). Hydrolyzes triacylglycerol (TAG), but has a low activity toward phosphatidylcholine (PC) and monogalactosyldiacylglycerol (MGDG).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MQTLTPNADIFHAKRRRFTCNTHTSTLIPTKPLSVSPARKTNKEHLRNLENVLRTSSNSIDHIENVTSRQEKTTKNTSTSSLLGGLNLARIWPQMKAAVDEMSPKNLKRLQRLLSKSSEERSPKSKLGSKWRELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDPEGSPRHVALPDGSFKVTKSLYATSSVRLPKWIDDVAPDLRWMTKQTSWVGYVAVCDDPREIRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQSDPTRPKVECGFNSLYTTGDQHAPSLAESLVGEISRLVELYAGEELSISVTGHSLGAAIALLAADDIAERVPHAPPVAVFSFGGPRVGNREFADRLDSKGVKVLRVVNSQDVVTKVPGIFADNDKQGQSRNNGRSPGGIMEMVERNNPWAYSHVGAELRVDMKMSPYLKPNADVACCHDLEAYLHLVDGFLASNCPFRANAKRSLRKLLDEQRSNVKVLYTGKSLRLNRTFHDNGDVLPSPSSS
The following text describes a protein:
Function:
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
Sequence:
MKNIIIIGANGFTGRQILNDLSSKAQYKVTGCSLHPDILPKNGGNYHFITTDIRDEAVVKQLFKDVQPDVVINCSALSVPDYCETHHEEAWLTNVTAVEQLAHLCESYKSRFIHLSTDFVFDGKIDEKSGQLYTEKSLPAPVNYYGFTKWKGEEKVTEICSNYAIARVEIVYGKALPGQHGNIVQLVMNRLNAGQEIRVVSDQWRTPTYVGDVSAGVQHLVENAANGIFHICGEECLTIAEIAFQVADYMKLDRSLVHPATTEEMQEATPRPRFSGMSIAKARTILGYQPRKLKDILMEWKH
The following text describes a protein:
Function:
May be involved in the regulation of gene expression responses of environment-sensing pathways.
Miscellaneous:
MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Peroxisome. Note=A fraction of the protein co-localizes with peroxisomes.
Sequence:
MPETSVQNPLRLSENENTRSMFLSASQQQRPSATPSFPRLVRNTTANLSLSDFQVLNPSSKRQNSNSVYDDINSSKRRISRPRFSDIEGKNNDHTYPERTTVKESEKNPSPRYVSSSKRALKRENSVGITQSSALISKSFSENGGSIAHEKWSPENMIKPLNVSQNSLAFVDAGSDEQSKSEIVGGFQRKSNNSQEINDKDNSARDQDFNNSGNNNNNNNHSSNNNDNNNNNNDDNNNNNNSNSRDNNNNSDDSNEREENDSCKPASNKRSGIALIQKLQELYKVIVKQEIELQERCSQLTNSQTTELKSLWTIYKINTDLVNNYVTFITTALLPSQPPHDLVIGQEIVEIYRIERRLWVYGTITFLDVLKNFSNFMDPEVCCQFITHVFVSLSTMISDIPSKYSITWLQRLGDLSRMAIALYPSSFIDWKLSAEHWYTEAMKYIYNHGKLYYHMSTVQQNTLEAFVNLGKSVFCQETFTPSPQYMQLVIDNIYQRAFVERNNGNLRNSLLIEYLKHSEAMLLPSFLESPDLQNVVLSYFIEKFGIDANGCNIFNAEDMFVQNPDFFKYFFRHGPSFAQSHILQIVGFGEPKNPFAILFELPKYLKERKDKKERKKSSNNDSSVTESSTGNSRNDNEDDDEIMSSTTSISDHDLLAEFFNDIDTLRRPILPSMLTNEAWLETLKFLNMTSLKCGIIVLRKFLHGPLGIALPHILPWIYFIISICLKSSQLSDPVSKEFWMIIVKRAFPWDTMVTFMNVLIVYLLDNQTSNSIIGDLCDDYDKLSLSELLELFNEGEELPEILGCWGTLWFDTICEKNTHSISSEDNFQEIGIKDYMALDSPTDGIIFDEKDENGEKFWKRACRTIFLFRELSRSFPIGVIIRNDPLIYRSSFQNTNILGSLVFKLEPLCNIHNNIPVLGALESIIDISEARSENNTDLHAVPELSVNEGDNIFHYVGYKKLRADYTCFDKNGEFLSASLYTTWYVPNSNNTNIEDNINYNSEKENEGLFLECIKSDYPEIDFKTTYFVFDATSWLRHSARIFKLAQNRLLRFAICLTTFQELRFLRKSKDENVMEAATRGIITIRQLYYENKVLPLRFTGNVATHIEENLEFEEQITWRTHVDEFVIESVMKAQEKLESASEPRLSPRRFNYVVLISDDDAMKKKAEEKEIKTLSTRFVFSLCTKLGEQRHLCTD
The following text describes a protein:
Function:
Component of the DprE1-DprE2 complex that catalyzes the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate channel' at the interface of DprE1-DprE2 complex. DprE2 then catalyzes the second step of epimerization, the NAD(+)-dependent reduction of DPX that leads to the formation of DPA. Appears to be essential for the growth and survival of M.tuberculosis.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Periplasm.
Sequence:
MVLDAVGNPQTVLLLGGTSEIGLAICERYLHNSAARIVLACLPDDPRREDAAAAMKQAGARSVELIDFDALDTDSHPKMIEAAFSGGDVDVAIVAFGLLGDAEELWQNQRKAVQIAEINYTAAVSVGVLLAEKMRAQGFGQIIAMSSAAGERVRRANFVYGSTKAGLDGFYLGLSEALREYGVRVLVIRPGQVRTRMSAHLKEAPLTVDKEYVANLAVTASAKGKELVWAPAAFRYVMMVLRHIPRSIFRKLPI
The following text describes a protein:
Function:
Serine/threonine protein kinase which may function as an adapter protein for BRL2. Required during vascular development for the establishment of vein pattern in foliar organs. Mediates MSSP1/TMT1 phosphorylation and activation to enhance its carrier activity and consequently vacuolar sugar accumulation, particularly in response to cold.
Subcellular Localization:
Vacuole.
Sequence:
MSSDSPAAGDGGEQAAAGTSVPSPSYDKQKEKARVSRTSLILWHAHQNDAAAVRKLLEEDPTLVHARDYDKRTPLHVASLHGWIDVVKCLLEFGADVNAQDRWKNTPLADAEGARKQKMIELLKSHGGLSYGQNGSHFEPKPVPPPIPKKCDWEIEPAELDFSNAAMIGKGSFGEIVKAYWRGTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHQYLKEKGGLTPTTAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRRYDKKVDVFSFAMILYEMLEGEPPFANHEPYEAAKHVSDGHRPTFRSKGCTPDLRELIVKCWDADMNQRPSFLDILKRLEKIKETLPSDHHWGLFTS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MANDISCCFYNGTSDENPFQMGEDNGSRARNCEKTNKDEMENTDFSLETCGGTNTTDRTAHKAEKRFFCIDCGKSFTRKSTLIVHQRIHTGEKLFMCTECGKRFGLKSSLVRHLRTHIPKTLNFCPDCGKGFSRYSSLFQHQKVHRHEKLYKCCHCEKSFSCNSLLAAHQAIHMANELSDGKQHREQISDQDKINEHCRKDNMAELPAFKDSARSFIREESGMRPPPPYTENSTFFSKTECEEIYISISSQDGETEVDDTKPASKRNSYVKPCKTDIQKENHTMSIEESKDLSAQLERTTQKEEKRFLCIDCGKSFTRKSSLIVHQRTHTGEKLFMCTECGKRFGLKSSLVRHIRTHMPKTIDICPECGKCFSRYSSLFQHQKSHRLEKPFKCSQCEKSFSRTSQLLIHQKCHKSGKAFDKKEHRENVRCQTKLRNGSRYDRIQETHAYSQCSKTFRQKESLLLHQRKRTVDQLDQFSSHPDSPDTKTTTNEKPGNPKDSAKKWSKEPEPEKADGLNGEKRCLCIDCGKSFTRKSSLIVHQRIHTGEKLYMCTECGKRFGLKSSLVRHVRTHIPKTLNICPDCGKCFSRYSSLFQHQKVHRRDKQYKCSPCDKSFSRPSQLLLHQRNHKGEKLVESKESEDNCAQDKYHEHTGSDATEMSHLCLQCDKSFSEAAALIRHKRIHTDSSESRTKHKDGESSHGHSDSLDRNSSLLSIPSNAEEHFKIPSNTSPIITKPISEKQRRNGLENQKCSEKFRDRAIKRAHGENQHLCSECGKNFTRKSSLIVHQRSHTGEKLYMCSECGKRFGLKSSLVRHLKTHSGPPINICSECGIYFTHYSDLLLHLQVHKGQQQLKVSDVSKEEPKECKVLIEGHESLEEISILKEQEVSRSRIQHPLMAEPVHVNQLLDSKCSDDDKRNPCEASVQVKEELPENIYTGEQNTEEEKNEEFPAYPYLIDWGVEFDISKPLNADDNPGKVQETSKRNEIHSDKGSTIGQEIPSFEINVWGRSNSTERHYCGDKRFLCIDCGKRFTRKSSLIVHQRTHTGEKLYMCTECGKRFGLKSSLVRHQRIHSTEFFTCTQCGKSFRDYSKFLHHQANHTGEWSYREPHLSVN
The following text describes a protein:
Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTVHAPLPQHTQTAAKRGVWEVIKDFMMTTDHKKIGLLYIIVSILGFCLGGLLALAIRVQLALPEQTLLVGTTYNQVLTMHAAIMLFFFLIPLGLFGFGNYFLPLQLGVRDVALPRLNTFAVWLFIASLILVVLGLFNGGAPSVGWTFYYPLTMDGNQTGVSVFMVAVILNGLGSLLGSANFAATIVNLRAPGMGLWKMPVFAWSIFATSILQLLTLGGLTAAALLTYLEIKLGLSMFNPGIGGVPVLYQQFFWFYSHPAVYVMLLPYLGIGAEVASTMARKPLFGYRVMVYSMLAIVLVSCIVWLHHMFAVGIPEAWQIAFMISTLIVAVPTGVKIFNLIGTLWGGRILMRMPTYWLIGFIFNFLIGGITGVSLGMIPFDYQVTMSYYVVAHFHNVMMFGTAFLAMAGLYYWWPKMTGRFLDEKVGLAHFWLFMIGSWLTFLPQYILGLLGMPRRYYTYPAGNWAWTELNFASTVGAFLLLLGGLAMLYNMFQSFKRPITAGPNPWGGFTLEWTSSSPPAAYNFAHDFPQNFPTERPLYDWEQNGETLTPVDPKSIHLPQDSIWPFMTAFSLLLMGYGLSFGWFTNYDPAVGLKPFADASLSFKIATTVLYLSLPVFFYSLFKWAGTREYAVPVAHHHLTKYDNGFMGMAWFIISEVALFAILIAGYVYLRVIGAAEPPALRPSIWLAALNTLILVTSSGVVHKAEQDLHHGRTSWGRLGLFITLLLGAIFMIFQVYEFSLFGTESDWRQNLWQSCFFIIVGLHGLHILIGGTGIALPYYQLLTGKMDKYNHGSIVPASLYWHLVDVVWLLIVAIFYAW
The following text describes a protein:
Function:
Probable amino-acid or metabolite transport protein.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MMNTEGNNGNKPLGLWNVVSIGIGAMVGAGIFALLGQAALLMEASTWVAFAFGGIVAMFSGYAYARLGASYPSNGGIIDFFRRGLGNGVFSLALSLLYLLTLAVSIAMVARAFGAYAVQFLHEGSQEEHLILLYALGIIAVMTLFNSLSNHAVGRLEVILVGIKMMILLLLIIAGVWSLQPAHISVSAPPSSGAFFSCIGITFLAYAGFGMMANAADKVKDPQVIMPRAFLVAIGVTTLLYISLALVLLSDVSALELEKYADTAVAQAASPLLGHVGYVIVVIGALLATASAINANLFAVFNIMDNMGSERELPKLMNKSLWRQSTWGNIIVVVLIMLMTAALNLGSLASVASATFLICYLAVFVVAIRLRHDIHASLPILIVGTLVMLLVIVGFIYSLWSQGSRALIWIIGSLLLSLIVAMVMKRNKTV
The following text describes a protein:
Function:
Zinc chaperone that directly transfers zinc cofactor to target proteins, thereby activating them. Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.
Sequence:
MNSLAKVPVTVVTGFLGSGKTTLIQHLLANPNGKKLAVLVNEFGSEGVDGQILKSCADANCPEENIVELANGCICCTVADDFIPTMELLLARPVRPDHILIETSGLALPKPLLRAFDWPEIRSRITVDGVIALADAEAVAAGRFAPDPAAVEAQRAADENLDHETPLSEVFEDQIACADIVLLTKADLAGPAGLEAAKAAITAEMPRRVPMLAVTDGAIDARVILGLGAAAENDLAARPSHHDGEEEHEHDDFASVVIDLPEVGDVDALVASVQRLAREQNVLRAKGYIAVAGKPMRLLLQAVGERVRHQFDKPWGALARQSKLVVIGEHGDIDEAAIRAGLGLSGSGI
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MEDFLGLKWQENPRAGKKKKKEESASCDSELQLQNPQVHSTSSRVSSKVEQARRWKQVTNRTPQYMTLEAAQLQLVGHDHPLFLPTSNKYPFDFNRKRPPFLEGYHDAALKFPFPKEVHHGPALGEISSVGPSFISQAQTTDASAKGSLGHTPEIRSEAMLSQGPALLTIFYGDGVYVYSDITPEKAELIMSMAREQPTTLSTSQAQHLEVASNIHRPRATYPQGTLPQARRATLVRFLEKRKDRLSSDIYNLIKKSSESTIFPQRS
The following text describes a protein:
Function:
Catalyzes both the acetyl-CoA-dependent N-acetylation of aromatic amines and the O-acetylation of N-hydroxyarylamines. In vitro, catalyzes the O-acetylation of N-hydroxy-Glu-P-1, and the N-acetylation of isoniazid and 2-aminofluorene.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSFLHAYFTRLHCQPLGVPTVEALRTLHLAHNCAIPFENLDVLLPREIQLDETALEEKLLYARRGGYCFELNGLFERALRDIGFNVRSLLGRVILSHPASLPPRTHRLLLVDVEDEQWIADVGFGGQTLTAPLRLQAEIAQQTPHGEYRLMQEGSTWILQFRHHEHWQSMYCFDLGVQQQSDHVMGNFWSAHWPQSHFRHHLLMCRHLPDGGKLTLTNFHFTRYHQGHAVEQVNVPDVPSLYQLLQQQFGLGVNDVKHGFTEAELAAVMAAFDTHPEAGK
The following text describes a protein:
Function:
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Sequence:
MARVWLFGPDINTDQIVPGRYAPYMLKDESELRRYPFIEHRPDFAANVRPGDIIVAGKNFGCGSSREYAPLALRMVGIGAIIAPLFARIFFRNALNLGIPCFTADLTGELADGDEVELDLEQGRITTADGRVIHLPPPPLFLREVWAAGGIVPFYRTYGRFPGEVA
The following text describes a protein:
Function:
Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP5 is essential for DNA-binding activity. It may be the linchpin that binds to the subunit association domains (SAD) of HAP2 and HAP3 to bring these proteins together.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTDRNFSPQQGQGPQESLPEGPQPSTMIQREEMNMPRQYSEQQQLQENEGEGENTRLPVSEEEFRMVQELQAIQAGHDQANLPPSGRGSLEGEDNGNSDGADGEMDEDDEEYDVFRNVGQGLVGHYKEIMIRYWQELINEIESTNEPGSEHQDDFKSHSLPFARIRKVMKTDEDVKMISAEAPIIFAKACEIFITELTMRAWCVAERNKRRTLQKADIAEALQKSDMFDFLIDVVPRRPLPQ
The following text describes a protein:
Function:
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSQDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLGRSRYTQEYICQIFSHCCKAPDHQTILFNHGAVQNIAHLLTSVSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVNGLSESSIKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAIELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFQLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKELIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDIGIVDILHKLSQSPDTNLCDKAKTALQQYLA
The following text describes a protein:
Function:
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MISTLRRAVFLRRFPAVVSPIKRAFSSRIDDEFDPQIMNINELNQEMQSIFGQEPSPDGPGTMDFSELKSSKIEPLRSKNIDFRQQIEYHKSTHSSKNDSQAIEQYAKVASDMSKLTHVGIAGEAQMVDVSSKDNSKRTALACCKVILGKRVFDLVLANQMGKGDVLGVAKIAGINGAKQTSSLIPLCHNIALTHVRVDLRLNPEDFSVDIEGEASCTGKTGVEMEAMTAVSVAGLTVYDMCKAASKDISITDVRLERKTGGKSGSWSRL
The following text describes a protein:
Function:
NAD-dependent (R,R)-butanediol dehydrogenase which catalyzes oxidation of (R,R)-butane-2,3-diol to (3R)-acetoin, of meso-butanediol to (3S)-acetoin, and reduction of acetoin. Allows the use of 2,3-butanediol as an aerobic carbon source.
Miscellaneous:
MISCELLANEOUS: Present with 8730 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVEVFNPSKHGHKSIEILRGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPKPVPFQPMDVTLQEKVMTGSIGYVVEDFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEKGFQELMDHKESNVKILLTPNNHGEMK
The following text describes a protein:
Function:
Regulates CDC48A by inhibiting its ATPase activity and by promoting the disassembly of the active hexamer.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Produced by alternative initiation at Met-22 of isoform 1.
Subcellular Localization:
Cytoplasm.
Sequence:
MFVDDPSLHTLKRRRLEITDSMEASSSAQAKIADMREKLGREVRVFETSSISQRPSQVSSADDESDDFYEFTPADFYRLLATKKEDKSLKTRKIREAEEAARRSKLTKAVIRVRFPDNHTLEATFHPSEKIQGLIDLVKRVVAHPDVPFYLYTTPPKKQIKDFSQDFYSAGFVPGAIVYFSNDQPKDDGGSSTPYLNEEILSLKDLEAMTKAVEPVESSSEPATVDSSAVPVEHERKSTEKKTTKPKWFKM
The following text describes a protein:
Function:
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MASDTEKLMCLTTENAEIPADFVELQPLDEIETVSLETNVSQTIEVYGDVGVDWAHGGHYHSPLIALQPLAGSNLSNGDHDQEMIIVQTREEVVDYQDSDNLLLGTEFESQMVLPVNEDDYLQPTTATFSGFMAAENGQDELSPYGGNLCGLTTIIEAGAEEGVNPDLGDKQWEQKQIQIDGLDGEFPFAMWEDNNLKEDPVAEEEAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRSNKDCKSSSSSSFCIVPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTARFYISPDSYNAGNTV
The following text describes a protein:
Function:
ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (By similarity). Plays a role in mitochondrial iron transport (By similarity). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MFHFARCSRLTRGTVTSDRLLSSHKTRDFLFQHLNRRGNHSAPWSSSQIPSTQLTVGVPVLRVWRQAQKLLRLTSRQQPRPPSIALKFILGPAALTVTARLLGPSAHCEADVNNNKVPLEVQVKEKIPEFSWAVLWEFVRPQLFALMGAILLAFGAAALNIQIPLMLGDLVNVVARHMREQAGHYMRDIQAPAVKLLGLYALQGLLTSGYIILLSRVGERVAADMRTTLFTSLLRQDIAFFDANKTGQLVNRLTSDIQEFKSSFKLVISQGLRSATQTVGCFVSLYFISPKLTGLTVVVLPCLVGAGALIGSFLRKLSRKAQEQVAKATGVADEALGNVRTVRAFAMEDRELEMYAAEVQKSAAMNETLGTGIAVFQGLSNIVLNCIVLGTIFAGGSLMARDDLSPGDLMSFLVASQTVQRSLASISILFGQMVRGMSAGARVFEYLALDPSVPLTGGGRIPLDSLMGRVDFMNISFSYPTRPGNQILKHFSLTLPPCKTVAIVGESGGGKSTVAALLERFYDPSSGVVMLDGLDIRTLDPSWLRGHVIGFISQEPVLFGTSVMENIRFGKPSATDAEVVSAAKQANAHNFITGFADGYNTVVGERGVTLSGGQKQRIAIARALVKNPSILILDEATSALDAESERVVQEALDRATTGRTVLIIAHRLSTIQAADLICVMSNGRIVEAGTHLELLSKGGLYAELIKRQRSNGHK
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
ALNASRLYGAVSPTKSAAAEAEAKRWQLDLSIQIHDRSLACEILSMPEDKWCEIGNNLNRPYGEGSSSSSNQHQACGFRSNQQFFGCRVYVKGLIDGLAGGIGVAICDSIGNLLFELGKTFSGEDRQWNALCVEMKALIEGLSIAVMLGLNRVTILTDNNLLYLHVSPLFQFEIMVKSNVATLSDEIKLLLRKLTQPCATLVPEKDLELASAIARNAMAFNVNRISCSICFEDTYMNQMFQISYCLHSYCVSCMLKHVEFKLLQGTLPRCPHVYCNSELKLDSCKKFLTSELSDLMNQRLKEASIPVEERIYCPCPTCSTLLSITELQTFIGSSDFVDDELGARKCPKCSGIFCVKCKVPWHGNMSCRDFLRLNPIPREEEDNKLKSLATQNLWRQCPKCNHMVSLAEGCYHITCRCRHEFCYTCGAEWKNRRSSCTCPLWDERNIVYDRRNPIPRR
The following text describes a protein:
Function:
Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MEEIQMFYNTSPSGSDTDDSRFSTASSPPKRKQKVRTKARYSIYNLNPLPPPPSELDQIPDALIPPSHAGRKRTFPHVEGNFPSYVNIPVPVTLGARNVLESLLGKASSMMPQLRGMDDDIVVSFKRRDTTSRSNADSGIQLAKEFHISLSRTVPIRVHQIDTLIPLLRHKFESQKRFWIEFGRWEIYLNDDRSRTFLGLEVVSGGLSDIRRQIALVTEAYKLHGLPPFYDTPRPHISLAWALGDVSSDAQRVADELNELCGNSMDYGTGIVNVLWSFLFGRVDCKVGQQLYPIWVASTASHT
The following text describes a protein:
Function:
Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MDDKKTWSTVTLRTFNQLVTSSLIGYSKKMDSMNHKMEGNAGHDHSDMHMGDGDDTCSMNMLFSWSYKNTCVVFEWWHIKTLPGLILSCLAIFGLAYLYEYLKYCVHKRQLSQRVLLPNRSLTKINQADKVSNSILYGLQVGFSFMLMLVFMTYNGWLMLAVVCGAIWGNYSWCTSYSPEIDDSSLACH
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MTPLSPSEQERHRETASPVPNAPPPPPQGSGPSKTQRPAVATAMMPGGGGTERAREGRLAGAVSWMAALLLAAVVAGRDAAVPRKKRGPRVRAETSRWWSFRLPVPPPPATPRAGTCGDCGVTKTSQWRTGPMGPRTLCNTCGRRRWAAGEQWGEPRRRRRATTPTTVSDQPPPPPPDGPVWEGPLPEGYRTARRNAAKGSSPSPAPATATTDSDKPAPQNKKKNKAAAAAASEKQCVHCGSSETPQWREGPEGPATLCNACGLRYRQRRLLPEYRPQASPTFDKENHASMHSEVLELRQQSKNKQKQQQPPALAQPQPMDDTQQDVDHLMPPPLPRCVANDLRVGATDGDSANKASGSGAAVASTDPVGEASSLDPFLLDGPAAPMVVDEPCWMIAGSSTP
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MLPPHQQPKSGVLHTSLTLVPGEACGSPNIQERGSNSDQIRDSPTESASSRETWPTPDPLTISKPLEAEHSVIRHITDKMSLRDISRERVDIIADRMHHLPNEYLDKLKNELRGLIEGMGDPCFSSPRTVRNLGRYKDWNPSFLHPTVSLSQASLIEIFLYKRCRNIACGNQIPADNCMCEICVKRNGFCNLCMCVICSKFDFEVNTCRWIGCDVCSHWTHTDCAIHNAQIGNGGSLGEMVFRCRACMRTSELFGWVKDVFHHCAPLWDREALVRELEYVSRIFRGSEECGELVEKLKTGVAEPVASKAILSFFQEFDIDPRKHEESGGVMALQEAFNRIADVVQEAIKKMEMVEEEKVRMTKKARLALEACDQELKDKAREVAALKMERQKKKQQVEELQSIVRLKQAEAEMFDLKAAEARREADRLQRFALAKVEKSEDDYASRYLKQRLHEAEAEKQYLFEKMNSGSSGGGGGGGGGELSQMMMYNKIQDLLKNMYTVPTKGDGQAIHSCSNLTLYRIDRPCIEFDMHWIWFGLRLILKTFMYFQC
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRIAHPPVAVAFAATPEEDVFDSVRTAAAQLNVGGPGLRKKATGVRPWLLLDSTGQAQIIEAGKHAIMRRTGLPARDLRILDPILSYPSTVLGRERAIVINLEHIKAIITAQEVLLLNSKDPSVTPFVDELQRRILRHHQATSQEGLVDGDTEWRHLYDLGEPRSREVSPPRVSSSIPERGHEVKPDGKHSFDKRDGPKLLPFEFIALEACLEAACSSLDNEARTLEQEAHPALDKLTGKISTLNLERVRQIKSRLVAITGRVQKVRDELEHLLDDDEDMAEMYLTEKLEQQLDDASSSTFVNDEDVDEEILQTEIDDRVPGEESIDQQPEQLYRANTLGRESRGTRTSTTRSGHSKHLDVEELEMLLEAYFVQIDGTLNKLSTLREYVDDTEDYINIMLDDKQNHLLQMGVMLTTATLVVGAFVVVAGVFGMNIHIELFNADTGAEKEVGMRKFLWTVGGGTTGSIFLYVVAIAWCKSKRLLE