lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MASEASSSPRSVSSNAPTSSTQPRSAGPHGHPTFANISALDLLQTLPLTAAGRPALFGNEVEIYSEEHIGLYDRAVKTPHLHGRCSVTTHRLFYMDETSSPPVAFFVPLQWIARISKEAGFLQRSAKVRVDITTRTQPVATSFFKLSFKDGGRDDFFSPLEASLKRKAWRDTQPSHLADRRLVKRQFNAADAGIAGIMRRQQEAQKETTELAATAFSDLANLMIKARDMVSLIERYVDTQKAADTAGEDQQDGAATSREEDINKLSALMLDMGITSPVTRENSGAAYYEQLARQLAEYLTDHMPRNGGIMTLSDIYCMFNRARGVELVSPDDLYHAALLQKKLNLGYSTLIARTR
The following text describes a protein:
Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular Localization:
Nucleus.
Sequence:
MSEAQAVGTSSEITTKDLQEKKEVVEEAKNEREAHSDGNARVEMELQSLASTTATWDSSHVFTYTTAHGSAGSLTH
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNTTNTNEPEYINLPERKAEMLCCVCGALIEVNPSSMCANCLHKTIDITEGIPKQITIDQCKRCKKFLAGTTWFYCEPESRELMTYLIKRVKGLNKLKLINASYIWTEEHSKRLKIKLTVEKEVFKNTVIQQDFNVEFIIVNGFCDNCHKAEAKNTWQSVVQLRQHAEHKKSILTLEQEILKANAHQNATDIQEMPDGMDIFFQSVDHAKKFIDFLQTLVPLRYQQTKKLVSQDDHKNTYDFKVSFSVEVVPISRQDLVFLPKVNVNQLGGVGPLMVCTQVAGTLHLVDVLKGTEVELYAHQFFQHPFDALTNSKNLVEYYVVEVTKIGKPVGQYQLADCQIIKSEDFGVTEDYLYVKTIFGNTIREGETALGYDLVNLNANNDNFESYQQRGLEEGTLPEVILIGRGHL
The following text describes a protein:
Function:
Inhibits fructosidases from both cell wall (cell wall invertase CWI) and vacuoles (vacuolar invertase VI).
Subcellular Localization:
Vacuole.
Sequence:
MASSLIFLLLVTLTFSASTLISAKSNTTTIIESTCKTTNYYKFCVSALKSDPRSPTADTKGLASIMVGVGMTNATSTANYIAGNLSATVKDTVLKKVLQDCSEKYALAADSLRLTIQDLDDEAYDYASMHVLAAQDYPNVCRNIFRRVKGLAYPVEIRRREASLRRICGVVSGILDRLVE
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAHDLTQAICQNLDPHLILPLLDHCVDLDIYNEADLKRAKMQVLSRTRLIEQALELADATEKKDLDARMRSISEEEKTWEKQLEPVFEMFENDEVLSIIEATKNKDSLLSELEPYGFTENTADLLYHGSKFYFDRGQYDLAHGLLYNYRAVSTDDKLKFTALWGKLAAAILSGNWQTAQEDMYLLLEYIDGGKNELTAVEQLQQRNWLLHWSLFVFFNQPDGPDGIVDLFMNKETCTNAMQTIAPHLFRYATAVAIMSRRKKRDVMWEFVGIARQDKDLGDDPVVGFLVSLIKDFDFVTAEEKLQQCREVLSKDYFLAEMTDEFINTAQLYLFEVYLRVHSRVSIKNAATRLGKSEDDAEEWLVKLIRDAKLDAQIDPASGEIHITKPVTTVYQHVLDRTKNLQYRTYVIVESLHHLHPNGAFHHSNSSIPALFRRMMNEQLQGGGKSNKKGDYKKGDYKKGGDFKKGGDFKKGGDHKKRAWVK
The following text describes a protein:
Function:
Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNQRIETITALLDEKKAFDITHIDLSKTPYLVEDVIIATTLANKHALSLLDALKNTLKPLGEVFYQIDESNEEWIILDLGDLMIHLFTEECRKKFDLEGFLNAYKRGLPYQNA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
MKQAVYVASPDSQQIHVWQLDSAGELTLLQTVDVPGQVQPMAISPNQRHLYVGVRPDFGIVSYHIADDGTLTAAGMAPLPGSPTHIDTDRQGRFLFSASYSFNCVSISPIDTHGVVQAPIQQLDDLPAPHSANIDPTNQILLVPCLKEDKVRLFDLSAEGQLTPHAQADITVAAGAGPRHMAFHPNHQVAYCVNELNSSVDVYQISNNGQEYHLVQSLDAMPADFTGTRWAADIHITPNGRYLYISDRTANLLGIFTVSEDGRVISLVGHHLTEAQPRGFNIDHSGNFLIASGQKSDHIEVYRIDQNTGELTTLKRYPVGKGPMWVSIRGAQNS
The following text describes a protein:
Function:
As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MAAATAEAARSSSSSSSTGSGGSGGSSADSYVGSLISLTSKSEIRYEGVLFNINTQESTIGLRNVRSFGTEGRKKDGLQVPPSDKIYEFILFRGTDIKDLQVKSSPPVQTATPVHNDPAIIQSQYPQAATASMNLPPSGNGSLTDPSSHASSNGLPRPTFQGSLPQYQPDASLESWGPSHLLPTTNGSGLAMPMYWQGYYGPSNGVQAPQQALLRPPPGLSMPPSMMQSVQYPAMNASNTSASPLSESPALLPPFSTSTLNLQTSTLPSSRSSAMVSDSTNLTPDRVSTQTLPSNLPLASPLTTAVDKIAIASPGSYLPKTVPDPIMPFKRMSEPPSSIMRTSSSVLKEGKTPLVTPGQLSQPGPPIVPSLQSSQIAQKDVEVVQVSSPELSALPPTTAAAEVQKPILPLPSQPEHKIYGAPMYTYHTSRGGRGRGRENEISRSATRFEEDFDFTAMNEKFNKDEVWGHLGKSHKAQDRDDLLDEDDVGSSKLETKPVYVKDDFFDSISCDALDGGSRNGRARFSQQSRRDTDTFVNFSHHWGGRGGWGPGRGGRSRGGYYGRGYGYAGRGYGMSHGSF
The following text describes a protein:
Function:
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Sequence:
MSKIYFLVNGPGEISGWLYPLIRWIKEFKPSWAESFSFNSIIVPCQFASGEEEKVLRSWNFFKEIIPSNKYWDLFKDRVKDENSVLFHIGGDLYFNFILSKRWNSIPIAYVEKYFWIEKFYKKVYTLRDIKLKNSIFVGDLRFDFLPKDAFADNNKIALFPGSRSYVLRFFIPFYLALVKELVKDFPDLNFTFFISPFVDERIVKDTLKKLQTLIKELPINFETLDDMNKLKGFLMAITLPGTNTLQLAYMKIPMMIILPLHKPDFIPLEGLANFLKGNLREKLIEFYLRKNPYLALPNQIYPGIVPEIVGKFQFREVLNYIKEILYNREKLKKINKIMEEKFNKDYLTSELIWKDLYYEILSKIT
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIMYGYLVPWPHLEVSADRLSTWNQRVRVASSRDESAIVALQQCRNWIFWSNLTILFNKWILESTPFRYPILLTSWHLFFATLATQLLFRTSILATPRSIKMTPSLYMAKIAPIGLLYSGSLVCSNMAYIYLNVGFIQMLKASGPVITLLISALYGVTELTAAKLVNVAVITASVGLTVVSEIQFSWVGVAVQLVSLVLTSTSSSLSSPTLETHNAETGEEPGPLGTDTLHETSSKDEEEASTSENTARGQSQSLRLTNMDPLLSLYYTAPICAVMNGILAWRTEILPLLLDQIDPNSSSASEAAPAGLLGIILSTGLGTLLLNAVVGFMLNVAVFTLVYRQNLGSNNDALVFWGTSVSLLQAVGYAGALGGLVVYAGGGGYIRRGIWGAAVWARRKGMARYGYRGLGLGADGDREQKDCVKPK
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG. Truncated proteins consisting of the GGDEF/EAL domains (residues 319-747) or of the EAL domain alone (481-747) have c-di-GMP phosphodiesterase activity. They do not have diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKLNATYIKIRDKWWGLPLFLPSLILPIFAHINTFAHISSGEVFLFYLPLALMISMMMFFSWAALPGIALGIFVRKYAELGFYETLSLTANFIIIIILCWGGYRVFTPRRNNVSHGDTRLISQRIFWQIVFPATLFLILFQFAAFVGLLASRENLVGVMPFNLGTLINYQALLVGNLIGVPLCYFIIRVVRNPFYLRSYYSQLKQQVDAKVTKKEFALWLLALGALLLLLCMPLNEKSTIFSTNYTLSLLLPLMMWGAMRYGYKLISLLWAVVLMISIHSYQNYIPIYPGYTTQLTITSSSYLVFSFIVNYMAVLATRQRAVVRRIQRLAYVDPVVHLPNVRALNRALRDAPWSALCYLRIPGMEMLVKNYGIMLRIQYKQKLSHWLSPLLEPGEDVYQLSGNDLALRLNTESHQERITALDSHLKQFRFFWDGMPMQPQIGVSYCYVRSPVNHIYLLLGELNTVAELSIVTNAPENMQRRGAMYLQRELKDKVAMMNRLQQALEHNHFFLMAQPITGMRGDVYHEILLRMKGENDELISPDSFLPVAHEFGLSSSIDMWVIEHTLQFMAENRAKMPAHRFAINLSPTSVCQARFPVEVSQLLAKYQIEAWQLIFEVTESNALTNVKQAQITLQHLQELGCQIAIDDFGTGYASYARLKNVNADLLKIDGSFIRNIVSNSLDYQIVASICHLARMKKMLVVAEYVENEEIREAVLSLGIDYMQGYLIGKPQPLIDTLNEIEPIRESA
The following text describes a protein:
Function:
Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MPVQFKGLSEYDRNYTWKNHEDLEQEPTCSRWAGLRSDELGISKEPRFPSKRRVPYYKAQISKSFQWKEPRDNGYNISESIMEEPVQLRLDLDRESLAEEKLHTPDAPRLSEKANDYAVSSKMVKDVGSTVKKTAIEAPEDNRETVAPSKKVNSQAKANGVHRVLKKKAGLSTAPLQHPLKMSEYRRQFERKTPTENSPMLAAEQVIYNKNKSIPPFNVDALKTETEYKSRFKGSPPAKGPVLRKDWEEKHVPKYEPEDPSIKRKEKRIQINEAICSPPKNDKSETEAKQRIHARKHKEKVIQQLKHSSKSCRRIKSEYTSNFLSPSEYLYKDGAWVRAKKQMHEQDSHLPLGALWVAEINELREKADYYRRREQGTHFSRNHLNQILSVNNKFWDVSSNSSSEEQVSHNIKALDLAGFQAHSKKENVHKSSIEENEDTGTLGISDVPTVPVRRRLVWDENNNSELAQERAALTVEDKNVETTDADVVEDAEEMHAISEEVKRPDRLHSTTTNPSVDGLECISLPSEEGGRLPTPKLKEFGLSQRTHHDRTTPSTGGALLVSPMKEHLHTPEDKKKGYFVSSTPPKKAVCKKDIKTKLIKDKELTGTPNTSPPVAGIRTVDPLPLREDPWPIAYISNTSSPPRVTVPASKSPEPRAYVSMSPLWNTSCRIQGALRDPEFQHNGNFGSPGLHRTAYSDDCSIDDDRLSQISERSAATGSLASQVLERAQRRKEDFWGKK
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTVDLSPVQEYYKDKTIFITGASGFMGKVLLEKLLYSCHSLKEVIIICRPKRGKAPETRLEEMFKLPIFQRIKDERPEMLKRVTIYQGDVTFDQLGLSGESLKHVTENTNIVFHMAATLKLEGNLRDAIDMNLLGTRRALNVAKEMKQLEAFIHLSTAFCNCDQDVMYEKVYEFPHKPEDLMRLAEWMDVKTLDAITPDLLKPHPNTYTYSKRLAELLVRDHYESMPVIIARPSIVTPAVAEPLPGWVDNMNGPTGVLIGAGKGVIRSMICNGELKSEVIPVDIAINGLILLPYHNSLAEKRPLQIPVYNLTVDDAKKRTWKWIMDVGRDLGIKYPFEVGLWYPDGNMTSSKFYHTICTILFMWLPAYLIDFLLLIFGQRRFMIRVQTKIAVGLEVLQFFTTRSWDFKSTHFEQIYKELGSTDRRIFKINTDDVDDYEYMKVSILGGRQYVMKEPLTSLPKSRIQLRFMYVLDRICKTMIISGLLYWVSQKLRVVDLFRSVFHSST
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATETKPATEDVKIDLFEDDDEFEEFEINGEWEVKEEGKDATQQWEDDWDDDDVNDDFSLQLRKELENNTQKN
The following text describes a protein:
Function:
Probably involved in light/cold stress-related jasmonate (JA) biosynthesis. Contributes to the protection of photosystem II (PSII) against light stress.
Miscellaneous:
MISCELLANEOUS: Simultaneous down-regulation of PAP1, PAP2 and PAP3 leads to impaired long-term acclimation to environmental constraint, namely photooxidative stress imposed by high light combined with cold.
Subcellular Localization:
Plastid, chloroplast, plastoglobule. Plastid, chloroplast thylakoid. Note=Located in the elaioplast, a tapetum-specific plastidial lipid organelle.
Sequence:
MATVPLFTQFPCKTLNPSSSNTKHQSKSPILLPINSINRRSEIGVSVHRPDFKIRATDIDDEWGQDGVERVFASSSTVSVADKAIESVEETERLKRSLADSLYGTDRGLSVSSDTRAEISELITQLESKNPTPAPNEALFLLNGKWILAYTSFVGLFPLLSRRIEPLVKVDEISQTIDSDSFTVQNSVRFAGPFSTTSFSTNAKFEIRSPKRVQIKFEQGVIGTPQLTDSIEIPESVEVLGQKIDLNPIKGLLTSVQDTASSVARTISNQPPLKFSLPSDNTQSWLLTTYLDKDLRISRGDGGSVYVLIKEGSSLLNP
The following text describes a protein:
Function:
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of viriditoxin, one of the 'classical' secondary metabolites produced by fungi and that has antibacterial activity. The first step is performed by the polyketide synthase VdtA which condenses one acetyl-CoA and 6 malonyl-CoA units to form the heptaketide monomer backbone of viriditoxin. The product of VdtA is then O-methylated on C7 by the O-methyltransferase VdtC. The O-methyl group is important for the stereoselective coupling of the monomers at the final step of viriditoxin biosynthesis. The short-chain dehydrogenase/reductase VdtF then acts as a stereospecific reductase converting the pyrone to dihydropyrone via the reduction of the C3-C4 double bond. The FAD-binding monooxygenase VdtE then converts the ketone group into a methyl-ester group to yield semi-viriditoxin. Finally, the laccase VdtB is involved in dimerization of 2 semi-viriditoxin molecules to yield the final viriditoxin. VdtB is responsible for the regioselective 6,6'-coupling of semi-viriditoxin, which yields (M)-viriditoxin and (P)-viriditoxin at a ratio of 1:2. The non-catalytic carboxylesterase-like protein VdtD affects the stereochemistical outcome of the coupling. The highly reducing polyketide synthase VdtX is not involved in viriditoxin synthesis, but might possibly play a role in the production of additional metabolites not identified yet.
Sequence:
MDGKALTASSLFDITGRVAVITGGGTGLGLMMAKALEANGAKVYILGRRLEPLQEAAKQSTHGNIHPVQCSVTSHADLQGVVDHIAAKDGYINLLVNNAGISTPNLGPHATRPTPKWDISKVRDYWFHKSFADYAAVFETNTTASLMVTFAFLELLDKGNKKSEEEAKASQARNGAGKARIEYVRSQVVTLSSVGGFGRDNSAFIYGASKAAATHMMKNLATYLAPWKIRVNVIAPGYFNTDMMGNFYKATGGRLPASLAPEERFGDAQEIGGTIVYLASKAGAYCNGMVLLVDGGYVSNKPSSY
The following text describes a protein:
Function:
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MNRVAVVVLGDIGRSPRMQYHSMSLSKLENTKVTLIGYRESEPHPQIVNNDSITIEPLKPFPISMSNSFKKIPLISIFMWPLLAICKVLFQIIQLMYVLLVKVPSPLNTILVQSPPAIPTIFVMQIVCWIRGVHLVIDWHNLGYTLLKLSLSKSDNHPIIRLAKFIERYFAKNAYAHLFVTNEMKIQLVRDWNLKGKTFVFHDKASPIFKSLTDREQEEFLKTFINKYSIKGEDKVYIESVISKKSIRNPKQQTSIIISSTSWTQDEDFSILLDAIVKYDIEHAINNNNNKVEEAQDESVVLAENLLFIITGKGPQKEYYQEKINSLSLKKSRIITVWLDSEDYPKLLACCDLGVSLHNSSSGIDLPMKVVDMFGCCLPVLAIDFKCIGELVKVNYNGFLFKDSDQLHQLLNQLFTHPTNNNTITNTNNNKNLILEKMRKNLTKDRETDTWESNWLTIKPLFIPSSSSSSSSSSSSSSSSSSSSSSNSKSKKD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNIDEWQRIEETAPGNKCLAKLNELESILKDAKKSCLKDPTTSMKELVACSEKTQQVFDDLKRTEKKFHTSLNRFGKTLEKKFNFDLEDIKLHSSFESKKREIDTALSLHFFRQGDVELAHLFCKEAGIEEPSESLHVFTLLKSIVQGIRDKDLKLPIEWASQCRGYLERKGSSLEYTLQKYRLVSNYLTTKDIMAAIRYCRTNMAEFQKKHLADIQKTMIALFFCSRNEVLSGTNDSHDSIHHIISNNAQLNIPQEYIDVLDLDWKSLELLFVREFCAALGMSLESPLDIVVNAGAIALPILLKMSSIMKKKHTEWTSQGELPVEIFLPSSYHFHSVFTCPVSKEQATEENPPMMMSCGHVIVKESLRQLSRNGSQRFKCPYCPNENVAADAIRVYF
The following text describes a protein:
Function:
Involved in export of poly(A) mRNAs from the nucleus. Recruited to the coding sequences as well as poly-A sites of active genes.
Miscellaneous:
MISCELLANEOUS: Present with 1310 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDKAFDEIIGNSHTDSSSNHKVTRYRRRDLRNELGPRLGFAPSDAASRSKDRLYREREEPPLPKRIRISKIPLDVSDYTLDDMIKEFGSPIFSKIFDNKEDRTCIYEFEDPEVLEKIVERYNGHELHNAKIEVEIYQPQRKHSRMNAHNRRKQTAQEHGRGRPGSHYRQKPNRVSKKNKGREKNNTPTSVEALDAELDAYMKG
The following text describes a protein:
Function:
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, axon. Cell projection, dendrite. Note=Association with unc-101 is required for dendritic localization.
Domain:
The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region; The EQMIL and WNIIE motifs are required for dendritic localization.
Sequence:
MNSAIMQGAAMATSHGIARLNRHNAQRNHFHIPTANRLFYQLQTPCTSTEEERRTVQTDDVAEIGMQRPDYQMYCGEEEISEQFVKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVDIIEELEYWRIIPDQYLASCCCAQQIDDDDEEVEEQDKPNLFKTLRFGEIRRCVWNIIEEPASSGKAQAFAVCSVVFVLISISGLVLGSLPELQVATKQRNNLTGEEFTEMEPMPILGYIEYVCIVWFTMEYGLKMLVSAERSKTFRQLLNIIDLLAILPFIIEMLLLIFGISTEQLRDLKGAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKTLKASFRQLGMMAMVVMTGVIFFSTLVYFLEKDEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPGKLVATGAIACGVLVLALPITIIVDNFMKVAETERPAGGNRYRTSQYPKATKSEQMILKVT
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be involved in the regulation of autophagy. ESCRT-II interacts with bicoid mRNA, which is required for the anterior localization of bicoid mRNA in the developing egg.
Subcellular Localization:
Cytoplasm. Endosome membrane.
Sequence:
MAEFQWPWEYTFPPFFTLQPHEETRQQQLKVWTDLFLKYLRHTNRFTLSIGDQNSPLFHNEALKRRLSPELVLAILGELERSGHANPLDKRRQEWQVYWFTLEEYGNMVYDWVQETGQTNTICTLYEIASGENTSHLDFYGVDEAVLLSALRLLEEKGRCELIEMDGSHGVKFF
The following text describes a protein:
Function:
Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis.
Subcellular Localization:
Cytoplasm, cytosol. Lysosome. Nucleus. Preautophagosomal structure.
Sequence:
MMFVFHVDQGRMLTFKMECMFEDIRRLKELIERNHAIPARSIVLLVSGGELLEDESRACHYATGTDTNPIYMFCKTVGESPLLSPGPIKETEVDLDGLVRKSLELPVTFAGMAARAQLAQRIYEMGREELRRCESLIHEQHLQQQGWAAVVANMEDTIKEFQERCEYFNRYYEEQLRMYEEQMDILHSFDKSLQQLADIPILSSLMENAESRPYGVFDEVFNPSRAGSNTDQQSSSAAGGSAGGGGSGGVIVSTSAGGPSPGIEGNPDGDTVTEEGQKVEATGSGTELATVEDGGGEVALTEGERAKGISLLDWISAMEGQLTLKRMAEECRINIEKFNRNLLVNLNDRIEKAVKASQNVDIKVVKGLEERLRGLDELLAKAKKQLSDQNGLAEGIAKNQQSASKINDASVLPQLCVSHQNTLQLMKKNHADLLEYKRRCTVAKEELGLNLTKRIKYIMNVETRVHELDSTLQLYHTSLQRLQKHLSIIEQIHMVPCIYVSAVTEVVRRRMFSSAFLRWASDLACRLMAIHNEEVARRQDFTSIFEGHFLSSLFPGMTDMPPSYAIQAPSVFDSSLPALDKQDLEELSRYLPELTEKIPLPNIASVIDFFQTRSVEQQQLQQQDDGSGAGKDDASVRSKDGATSSSDNAAEQQSGGKESDKVGAESETDTEDYEKVQNQSPVGGRSTQEDAPAATVAVVETCSVATCTEPVETVCAETLTEVRYDDDTHPPNATTITGTNTTTPTNTVASCMHATNTLTSATTTTTTASADNVAIASVEHGGGEDVSGSGGGKLAEQQSAALLPGYHHPATILEENAASPAAGLVGSSLDGRCPLYVPASTLDGGRRLRRGILTRTSSSERSSSSQELLLLALMEPSPGSTALLRSPGDEGEFINSEFYIDESLPSSAASVERRQQLEHTSHQPYQQHQQQQQLYHQHQEFRASFADCLLARGRSSYDEGTVILLLQDNLGTTRLEVERLKGLLSSVYQLSQDSIMMLRDQLARVRAEADSNRTQFQSELGAMNRAWNDIQQLARNRERETIQQLTVDHELEMNDLRKSIHHKDDEIQSLRSDNSTMKASHIETVSSYEQEKRELSDQIAQMREVIRRLEEQLASAEVDRRKAIQEAIEQLEHKHRTEMESLRCRFKLMATSMDRSPSDTSLEKIEKPDMIDIGTHEQLLAQVRLDLQREKEQAIKAAVEEERQRWEANAIGGGGSSIVGSAGSAGNQRLHRSYGAAGSPGTGSQDVYKRILDEKDRQLEELREKEAQLMREVMRMRETIQSLTDPELSPLNDHSCREQMEALETDRQQLADRLDKLHDNLRTLEEEKNALACEVRKHRMDTAQLLTCSDGDTVTYVWNPKNSQYNIVQSGEFTYYLHESSYQALGLQPTVRGEQPDTLFGFGTVIHKEFCHARRDDNRYGVPQGACFYRVKLKPVNVSKKKKGRPSSSRGSGLSEMAPTPQQPPTAVVTIEMQSSSSSRSGGGGGGGGTLPITTSATAGQLIDSFAQTDHPTPSSTTTSSTTGGMADGSKSPTAASRDMIDSGVVEQQRSSYRERNISITDEEDGVVGSFGIGSTGSIDRIRYQSVCEEDDPADGDDDDDGDLADSAGGGGGSSATDHQQPSSCYASATDTTIVVTRTNQPPLIQASIAADSGNNSEASTASSTYPLATTSTNNSTAITATNSTAQQPVAGQSLLSIADDVSDSADSEYRSLEANDQEDSDSAVAPLPLAGSAGRE
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MPPANVAAPASLSPLPANAAGHTSIPSIRHYPFSLSSPYSTKLPSNDLYDATKKKKLPRPSEILFQPKVANYLANLVGTVTMPVKFRTSIDGKSWASTLISHQRPPFFNQSSLWLSIYLKSVTYQQIQWSKVLVLEMIPVNVLALLLAVFDAVYSIALMNFICTFQPFCCLSLSPIMLDWVEIFNCLYLHVSRGCVENCQETGCVGSQQCFQDCIFTADGNISDGRWYLQEPLYLKWKQWDCHSDCRYYCMLAREEERRKLGEKPVKYHGRWPFRRVYGIQEPVSVSFSALNLTIQFHGWISFFILVNYKLPLTDNRKRYYEYSGLWHIYGVLAMNCWFWAPVFHSR
The following text describes a protein:
Function:
Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate.
Sequence:
MRNHRISLQDIATLAGVTKMTVSRYIRSPKKVAKETGERIAKIMEEINYIPNRAPGMLLNAQSYTLGILIPSFQNQLFADILAGIESVTSEHNYQTLIANYNYDRDSEEESVINLLSYNIDGIILSEKYHTIRTVKFLRSATIPVVELMDVQGERLDMEVGFDNRQAAFDMVCTMLEKRVRHKILYLGSKDDTRDEQRYQGYCDAMMLHNLSPLRMNPRAISSIHLGMQLMRDALSANPDLDGVFCTNDDIAMGALLLCRERNLAVPEQISIAGFHGLEIGRQMIPSLASVITPRFDIGRMAAQMLLSKIKNNDHNHNTVDLGYQIYHGNTL
The following text describes a protein:
Function:
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQSYGGSVNYPPSFNNPKMEHGRNSYRRKGIDMGNIIGDPFALATTSIATLSWIIILFGSIFGFRDQNDGSNGAPVIVWPTYSWFTLVFNFFLILGIFIVIASDSAQTYHVAIVGYLAVGLVGSTSSINNLIYSGVASMEATAAGYILLSMVTIIWIFYFGSAPSAVPRAYIDSFALTKESTLPAHHMSRQTMNHNGLSSPNAYGSYNMRPETSASGLQPPQMYTGQLNGLENPARQSQIPQGFSSNNIPKPQGEGEIVPPTEYPYRAKAIFSYEANPDDANEISFSKHEVLEISDVSGRWWQARKENGETGIAPSNYLILL
The following text describes a protein:
Function:
Multifunctional protein required for genome uncoating and replication. Major viral uncoating protein that is required for the release of the viral genome from incoming viral cores containing the viral DNA genome. Possesses an ATPase activity that is required for hexamerization and uncoating.
Subcellular Localization:
Host cytoplasm. Note=Colocalizes with free cytoplasmic cores containing the viral DNA genome.
Sequence:
MDAAIRGNDVIFVLKTIGVPSACRQNEDPRFVEAFKCDELERYIENNPECTLFESLRDEEAYSIVRIFMDVDLDACLDEIDYLTAIQDFIIEVSNCVARFAFTECGAIHENVIKSMRSNFSLTKSTNRDKTSFHIIFLDTYTTMDTLIAMKRTLLELSRSSENPLTRSIDTAVYRRKTTLRVVGTRKNPNCDTIHVMQPPHDNIEDYLFTYVDMNNNSYYFSLQQRLEDLVPDKLWEPGFISFEDAIKRVSKIFINSIINFNDLDENNFTTVPLVIDYVTPCALCKKRSHKHPHQLSLENGAIRIYKTGNPHSCKVKIVPLDGNKLFNIAQRILDTNSVLLTERGDHIVWINNSWKFNSEEPLITKLILSIRHQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPFKNGVLDLVDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNIINDIQPLTDENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRLLKSAIGDLFVETGQTILTDVLDKGPNPFIANMHLKRSVFCSELPDFACSGSKKIRSDNIKKLTEPCVIGRPCFSNKINNRNHATIIIDTNYKPVFDRIDNALMRRIAVVRFRTHFSQPSGREAAENNDAYDKVKLLDEGLDGKIQNNRYRFAFLYLLVKWYRKYHVPIMKLYPTPEEIPDFAFYLKIGTLLVSSSVKHIPLMTDLSKKGYILYDNVVTLPLTTFQQKISKYFNSRLFGHDIESFINRHKKFANVSDEYLQYIFIEDISSP
The following text describes a protein:
Function:
Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
Sequence:
MSVTTQQPAVVPLPSSPRLPIESHAGPRSTQLPPSPPETVNGDDPKSITSTPAEPDFPLPPPANPKPQVLDIDKPTPDAHVPRDPRLIRLTGVHPFNTEPPLTDLYNEGFLTSPELFYVRNHGAVPEVQDEECLDWEFSIEGMVANPLKITLRQLLEEYENVTYPVTLVCAGNRRKEQNVVRKSKGFAWGAAGVSTALFTGVVMKDVIERAKPLRKAKYVCMEGADKLPNGYYGTSVKLNWVMDPNRGIMLAHKMNGENLSLDHGKPLRAVVPGQIGGRSVKWLKKLIVTAEPSDNWYHIYDNRVLPTMVDPDEAAKNPKWWMDERYAIYDLSPNSAIAFPAHEEKVVLASAENSYNVRGYAYSGGGRRITRCEVSLNKGKNWRLANIDYAEDKYRDFEGRELFGARLDMDWRETSFCWCFWNLDIATAELRDANDILVRAMDEAMCIQPRDMYWSVLGMMNNPWYRITIHHEGDVLRFEHPTQPALIPGGWMERVKKAGGNLTNGQWGEQIEGQELENTAVEEVKEIKMTKDGVNRIVELDELKWHESAEYPWFVVNDEVYDGTSFLEGHPGGAQSIISAAGLDASDEFMAIHSETAKAMMPAYHIGTLSPTASKQLSLEEPTSKQASSSSLRPTFLDSRTWSKALLSSKTKVSWDTRIFRFKLDHASQTLGLPTGQHLMIRLRDPVTREAIIRSYTPISQISEQGFCDVLIKIYADAPGREGGKMTKALDSIPCGHWVDMKGPIGKFEYLGKGVCSINGNERRVRSMKMICGGSGITPIYQVLRAILQDSADSTHCTVLNGNRLEEDILCREDLDRFAEENGERCTLVHTLTQAAEGWTGRRGRIGEELLKEFCGTEEDGLVLVCGPEGLERSVKGLLSGMAWRDDDVIFF