lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Peripheral baseplate protein that is part of the tail fiber network. Connects the short tail fibers to the baseplate. During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.
Subcellular Localization:
Virion. Note=Present in 18 copies in the baseplate.
Sequence:
MKQNINIGNVVDDGTGDYLRKGGIKINENFDELYYELGDGDVPYSAGAWKTYNASSGQTLTAEWGKSYAINTSSGRVTINLPKGTVNDYNKVIRARDVFATWNVNPVTLVAASGDTIKGSAVPVEINVRFSDLELVYCAPGRWEYVKNKQIDKITSSDISNVARKEFLVEVQGQTDFLDVFRGTSYNVNNIRVKHRGNELYYGDVFSENSDFGSPGENEGELVPLDGFNIRLRQPCNIGDTVQIETFMDGVSQWRSSYTRRQIRLLDSKLTSKTSLEGSIYVTDLSTMKSIPFSAFGLIPGEPINPNSLEVRFNGILQELAGTVGMPLFHCVGADSDDEVECSVLGGTWEQSHTDYSVETDENGIPEILHFDSVFEHGDIINITWFNNDLGTLLTKDEIIDETDNLYVSQGPGVDISGDVNLTDFDKIGWPNVEAVQSYQRAFNAVSNIFDTIYPIGTIYENAVNPNNPVTYMGFGSWKLFGQGKVLVGWNEDISDPNFALNNNDLDSGGNPSHTAGGTGGSTSVTLENANLPATETDEEVLIVDENGSVIVGGCQYDPDESGPIYTKYREAKASTNSTHTPPTSITNIQPYITVYRWIRIA
The following text describes a protein:
Function:
Together with AIPP3/BDT1 and PAIPP2, cooperates to form a BAH-PHD bivalent histone reader complex able to read histone H3 lysine 27 trimethylation (H3K27me3) and low-methylated H3K4 histone marks in order to regulate transcription, especially to prevent early flowering; promotes AIPP3/BDT1 binding to H3K27me3. CPL2 is subsequently recruited to form a BAH-PHD-CPL2 complex (BPC) in order to silence several H3K27me3 and low-methylated H3K4 enriched loci, including AGO5, via the phosphorylation state-dependent inhibition of Pol II release from the transcriptional start site (e.g. Ser5P-Pol II dephosphorylation). The BPC complex represses flowering by inhibiting the expression of several genes, including AGL6, FT, FUL and SOC1. Prevents the accumulation of intronic heterochromatin-containing genes (e.g. IBM1, At3g05410 and RPP7).
Domain:
The PHD domain (212-263) recognizes specifically unmodified histone H3 lysine 4 (H3K4me0), binding affinity being inversely proportional to H3K4 methylation level.
Sequence:
MADRRVGNRPMGRRGRLEIQSGTCNVCSAPCSSCMHHNAEFSGSKSDESSDENSHGVLASQCSFNGDNLLRSSGVNAPGSSHNTSSEASHLVNSNHDTSSENAESKEIIRSSDISHGPLLDRPHKDQDSMKVDSCNDHQARSTLGQGKVKEKSGAKNNEEKKNTLTGSSKHSGPRVGKSGENVLLNKADESNTSAMSDSESENDPEMLELDVKVCDTCGDAGREDLLAICSRCSDGAEHTYCMRVMLKKVPKGYWLCEECKFAEKAEKHKLETKRKRESEVNVNTQISSKRHIDKFEAVPDSKRLAVGAQIGSPKRSVLPRMSTLSRETSFKGLEKPTRKLAHYSSFNSHSSDDTESTRSTDSQLQSPKGSFLKSNSFNSLSSRSKVRPVDDDMLPRQKTGNENSSLEVKEGFSKNVGKSMSSRCIDVGSSNCNDSKVKGSKQLKDWSTEANPSASISRGNSSIPYAKSPRDLKDLQSDGKQGSLSKQARHLSRNRLEDIVASVGDSSKNEKCSSSEQISSEAKCKDELAQVDGVPRSREFREAGEKTKDAVGNHQKRNIGEDNNKGNRLRAAVDAALRKKPSFSKNRGLEQSDLPPVSNVDSGCNKALKCLSSKVPVIRDWPVGFQGLPGGHPNLRTDKQTNTVNEKQFTLAGTDATTASQSVEPEVNDPSVQSVMRDLPVAAPNVLSTTSAIPKPEYIWQGDLEVQKSRNLSAMHSGIQAYLSTLASPKVVEVVKQFPEKVTLNEVPRLSSWPAQFQDTGAKEQHVALFFFAKDIESYEKNYKPLVDNMIQKDLALKGNLEGVELLIFASNQLPQDCQRWNMLFFLWGVFRGKKESCSNPPKNTPLPASCVSPNRDTFRHENPSNKKSLTDRTLSRMQSCMKEEDAKEGKACSGTEKENAFSVSYGEGEVDVETEEGEIGVSPQLKYEKTAGPGTVKSADMNQRVNVDDLNKEGLCEGPANKKLKTVTGVETGCSIVRRDTSVHKFASRKFV
The following text describes a protein:
Function:
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus.
Sequence:
TKELLQLSRYGWYWGPISRLEAEEKLNGQADGTFLVRDSSDDHHLLSLSFRSHNVTLHTRIEHCDGVFSFYAQHESEGRSSIVELIESSVADSQGGVFCYSRARHPGSPSFPVRLVKPLSRLANVKSLQYLCRFFIRQNTRVDLIQKLPLPLSVRQWLEERQY
The following text describes a protein:
Function:
Involved in resistance to abiotic stress.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cytoplasm.
Sequence:
MSYQDPQHPVSAPPPQGYPPKEGYPPAGYPPPAGYPPPQYPQAGYPPAGYPPPQQGYGQGYPAQGYPPPQYPQGHPPQYPYQGPPPPHYGQAPPKNKKDKKDSGGFMEGCLAMLCCCVLLEACF
The following text describes a protein:
Function:
Generates GABA from glutamate. Likely to be responsible for the metabolism of glutamate via the GABA shunt to succinate during growth.
Sequence:
MPLHIVDKHKSLYDNYVQSATTEEIAKFKLADDPNEPETIKKLIMDELLLDGNSKQNLATFCQTDLDKNIHSIMDKCIDKNMIDKDEYPQSAEIENRCLHILADLWNAPDSSDTIGCSTTGSSEAAMLGGLALKWNWRENRKKLGLPYDKPNIVTGPVQICWHKFALYFDIEIREIPMENGRYVMNSEEVLKRVDENTIGVIPTLGVTFTLQYEDVFSISNALDKFEKESGINIPIHVDAASGGFVAPFIQQEIIWDFRLPRVKSINASGHKFGLSPLGVGWVVWREKKDLHKDLVFNVNYLGGNMSTFSLNFSRPGGQIIAQYYNFLRHGRNGYTLIQDACAQQGIFIGKELKKMGIFDLIYDGTGALPGVCWTISKNLPSEPLFNLYDLSEKLRSRGWQVASYSLPSSMNDVVVSRVVIRHGFSRDLSSLFVKDVQNAIEYFQKHPILRSLEKDEGENFHH
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDVESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWKLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLSDT
The following text describes a protein:
Function:
Transcription termination factor involved in processing of plastid transcripts (By similarity). Essential for embryogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLLHCNVSYYTSTFSFISSSLRRQDNADDSQDTVIRRRHNARSISLYIRHNRDLKLNKNPNESQETFVPPPPPPRRDLDGENRSKLLELSLVTRRTPQFPGSIYAQSASDADIASSLPSLRNFLGSDGDDDGESEREMIVKALEIRRKVTKEIIKESLVRKGRFGITYATNVTDRLGDFVDHVMIQAAALKRLPEFSESRFNLRARTVIEDSNFVPLVRWLKHHELSYNRIAKIICMSKGNLDSIRIMIEWLKSIHVKGEFIAVAFLRSGDNILQRNREELNEIVEYLESNGVRRDWMGYVVGRCPELLSFSMEEVKSRVDFFLKMGMNQNDFGTMVYDYPKIIGFFSFQVMEKKINYLKEFGLSTEEVGRLLAYKPHLMGCSIEERWKPLVKYFYYLGIPKEGMKRILVVKPILYCIDLEKTIAPKVRFLQEMGIPNEAIGNMLVKFPSLLTNSLYKKIRPVVIFLLTRAGVTQKDIGKVIAMDPALLGCSIGTKLEPNMRYYISLGIRFYQLGEMIADFPMLLRYNVDNLRPKYRYLRRTMIRPLQDLIEFPRFFSYSLERRIIPRHTIMVENRVNFKLRYMLACTDEEFERRVRDKVERRERFEAGLDSEDSQPSDENISDQEIAFSDEAEEEEDLTE
The following text describes a protein:
Function:
Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDPDEVNQALGHYLNDSESGELVVEDSTTVQVTNPEARKTGDKIEVYYSRKTTVVSPTNSDDEEGEFCSDSELLPAQGGHRSRATSFAGRVRAGSDDEMNPKHTVLRYRRKKGGQWREVNAQGTPDKRKDDEDELEVDVKEDRSEQTGIVTKTYEARWKVLKYEHLPEWLQDNEFLRHGHRPPLPSFAECFKSIWSLHTETGNIWTHLIGCVAFFLLACWFLTRPDNHIQFQEKVVFSFFFAGAVSVSDSRSPSTPSRVIRSTSSRYSANSTIWESRCSLSARLFQPKITYIAMVCVLGIGAIVVSLWDKFSESKYRPVRAAVFVGMGCSGVIPTIHYIITDGVHSLFADNSFHWLLLMAFLYLLGAALYATRTPERFFPGKCDIWFQSHQLFHTCVVIAAFVHYYGISEMAFARLNEQCPVR
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MARIKKIFTQEELKQIPCPYDHKHTIVRHRLEYHLKRCNARPVERTDPYYKKDINISTSTDASESSSFEIVDLSKEELSKWICLFNRISDSLPTPQKKVLFHPAMNARLEEGTKKKHAIQQASLLGHMEKLHYFDNQGSIYYEFGAGRAELSRYVQHCSQQENVYILIDRDSNRTKHDSRILKDSIKNNWPEPKIIRCKIDIKDLKLDFFASEFRNSGKPVFAYSKHLCGAATDLTLNCLKSSPPNALVIALCCHHHCRWRTLSTFAREQLSHWGISNPQEFQILRQMTGWAVNSLREHMHASGGADSHISGLSHEERVKIGLKCKHIINYMRKLECEKMGYESSLVYYVGEETTLENVALIAYKRIN
The following text describes a protein:
Function:
Catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Sequence:
MSTDYLTLNRTGDKMPIRGFGCWKIDTKDCEETVYQAIKTGYRLFDGACDYGNEVEVGRGINKAINEGLVKREDLFIVTKLWNTFHSKKHVRALFDRQLKDTGLEYFDLYLIHFPVPLQYVDPATVYPPGWYVGDAKSLQFEQSPIHECWAELEKIVDAGLARNIGVANFNCQAILDLLTYARIKPAVLQIELHPYLPQERLVKWVKEQGIQITAYSSFGPTSYVDLTESGKTYTSLLEHASVKSVADKHNVSTGQVLLRWALDREFAVIPKSVNAGRMKANLEILDIKLDAEDNKTLDSLKTNQRFNDPMTYGFGLPLFD
The following text describes a protein:
Function:
Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSAPPWQTSEYDETEGFTSNQEGPSAAPSKTVASDWHEVKTEDSRVYYYNSVTRKSVWEKPEELMNDFEKKLSKLAWKEYATADGKKYWYNVNTRESVWDIPDEYKAALVDEPEQQKKALSSKIKSNDNKPAVQSIQRHGPDVAAPSSQPAKDQSQQISQGSHKRTINFVQQKDKRQKRSNDYQHENYDTYEAAERAFFKFLDSHNVNPSWTWEQTVRELCDAKGYYVMKDPWHRKCAFDAYILNYLTDQSDAEKNRVTKIRKEFIEMLKSSDKIHSYTLWRTVKNEFSSHPAFNATSSETEQQQLFFEYKQKLLEDEKQLEKDRRKEALDDFCSLLRNMNFEPYTRWSVAQAKFDQDPRYTRNSNMKYLSKLDALVAFEDHVKHLEREYILDKQKQKKEKHRIERKNRDAFRALLQDLRVQKKITLRTKWKELYPIIKDDPRYLNLLGQSGSTPLDLFWDTIVDLENMYREKRNLVLDCLEVLQISVDDTSNIPEIIARLSEKLKDREESEAVTEDLIEEVVNRLRDKAIHKKAEEKRADERRIRRKIDNLRSAIKYLKPPISADASYDEIRPLISILPEFAALHSEEHRMAAFDKYIRRLREKRELEKQYQNRRGYYDVGKDESYLANSARPHSGYEDGRLEYSADLASKSNRNEINTMQDVQENSISHVTATQPAVKNIVDDAESSEEGEIR
The following text describes a protein:
Function:
Protein adapter involved in piRNA-directed transposon methylation by connecting PIWIL4-piRNA and DNA methylation machineries. The PIWIL4-piRNA pathway plays a central role during spermatogenesis by directing transposon DNA methylation and silencing, thereby preventing their mobilization, which is essential for the germline integrity.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MEQPKDGAGPEGNNLSLPSSGTEPWPPAPLPAPPPLLLNSTDPTHLGLPESVASVTVPIRLDTLSCLLHSALLGAYTFQQALPSCPCCSQAGHSQPGAVRRPPRGRGGWEVRHRPGWGRGLHRRGLGRAEQPERGRAGGPGAGPRTPPMTLPSPPTLPAQDGKKEARGPEPPLETPLAAEDWETEY
The following text describes a protein:
Function:
Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Interacts simultaneously with both 'Thr-187' phosphorylation sites in a crb2 dimer for establishing the DNA checkpoint.
Subcellular Localization:
Nucleus.
Sequence:
MGSSKPLKGFVICCTSIDLKQRTEISTKATKLGAAYRSDFTKDVTHLIAGDFDTPKYKFAAKSRPDIKIMSSEWIPVLYESWVQGEDLDDGLLVDKHFLPTLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQSIQRNAVLEPQYFQLDMPAEKIGLGAYVRLDPNTTEAKSYSENQKISKNKEKSGQSLAALAEEADLEPVIMKRGKKRDRSILWEELNNGKFEFSSRSEENSVLLDDFTPETVQPLEENELDTELNIENEAKLFKNLTFYLYEFPNTKVSRLHKCLSDNGGQISEFLSSTIDFVVIPHYFPVDELPIFSFPTVNEWWIERCLYYKKIFGIDEHALAKPFFRPSLVPYFNGLSIHLTGFKGEELSHLKKALTILGAVVHEFLGVQRSILLVNTNEPFSMKTRFKIQHATEWNVRVVGVAWLWNIIQSGKFIDQVSPWAIDKKENQEIKKFTNQNNMVFPTSDRDTRLQNSLAQQPIGHSTPHNSPSLLSVKKRQNNHIRSNTLIQLNSNSKDSTIFPRRSVTVPGDKIDTVWKSSVTKPETPTSPQEHVSYIDPDAQREKHKLYAQLTSNVDAIPPANDLQNQENGLLLITESHRKLRRR
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MPLVNPLFFLLLISFSLATLIPFNVCSEIKTFTISTIEGLPWPPVSGLASVITFTGKFNKKVDSLNLYTDLWMKVGSSWISVPQLSKDLCKLELYCPLNDGTTSFKIRFEVPPITPIGTKWKGQFQFKSNNGTLFSCSEFGPVLVK
The following text describes a protein:
Function:
Orphan nuclear receptor. Regulates expression of genes involved in fat metabolism and in maintaining homeostasis of fatty acid saturation, such as lipid desaturase fat-7, and acyl-CoA synthetase acs-2. May form part of a negative feedback loop with fat-7 to limit mitochondrial beta-oxidation, in which it stimulates expression of fat-7 and acs-2, and in turn fat-7 indirectly inhibits acs-2 and other genes also involved in beta-oxidation. Acts in multiple somatic tissues, probably cell non-autonomously, to regulate response to a low oxygen environment (hypoxia). During hypoxia, activates expression of acs-2, various autophagy-related genes, and the formation of autophagosomes, independent of hypoxia-inducible factor hif-1. Furthermore, activates detoxification gene flavin mono-oxygenase fmo-2, acting in parallel with hif-1, during hypoxia. As part of a lysosome-to-nucleus retrograde lipid signaling pathway, acting in concert with nuclear hormone receptor nhr-80, activates the transcription of genes promoting longevity and mitochondrial beta-oxidation. In concert with nuclear hormone receptor nhr-66, involved in regulating target genes with roles in sphingolipid breakdown and lipid remodeling. Also involved in regulating fatty acid desaturase genes, acting in concert with nuclear hormone receptors nhr-13 and nhr-80. Plays a role in modulating mitochondrial morphology and function. Plays a role in transgenerational lipid accumulation in response to a high-fat diet.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MDYFLDASKHIQLNQIDEESSDDFMDLVDPLAEPCAVCGDKSTGTHYGVISCNGCKGFFRRTVLRDQKFTCRFNKRCVIDKNFRCACRYCRFQKCVQVGMKREAIQFERDPVGSPTSGASLNGTPFKKDRSPGYENGNSNGVGSNGMGQENMRTVPQSSSVIDALMEMEARVNQEMCNRYRRSQIFANGSGGSNGNDTDIQQGSDSGASAFAPPNRPCTTEVDLNEISRTTLLLMVEWAKTINPFMDLSMEDKIILLKNYAPQHLILMPAFRSPDTTRVCLFNNTYMTRDNNTDLNGFAAFKTSNITPRVLDEIVWPMRQLQMREQEFVCLKALAFLHPEAKGLSNSSQIMIRDARNRVLKALYAFILDQMPDDAPTRYGNILLLAPALKALTQLLIENMTLTKFFGLAEVDSLLSEFILDDINDHSTAPVSLQQHLSSPTTLPTNGVSPLNPAGSVGSVSSVSGITPTGMLSATLAAPLAIHPLQSQDSILNSEQNNHML
The following text describes a protein:
Function:
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is required to anchor melanin to the cell wall, for maintenance of cell wall integrity, and for proper cytokinesis. Chitosan offers an advantage during infection as it is less readily detected than chitin by host immunosurveillance mechanisms.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MYGHLSLSALSLFAVVAAAPFRESWLQPRDSPVSQLFRRTAPDPNSNDYMSYYPGPGSTPNVSTIPQAWLDKLATVNLPNVPVATPDGGRPTYPNNEDDGDSTICSFTDQCRVEDDLYSPPGEKIWALSFDDGPTDVSPALYDYLAQNNISSSATHFMIGGNVITSPQSVLVAVKAGGHLAVHTWSHPYMTTLTNEQVVGELGWTMQALSDLNGGRIPMYWRPPYGDVDNRVRAIAKEVFGLVTVLWDSDTNDWAITDEPGQYSVASVEAYFDTLVTGNRTQGLLLLEHELDNNTVEVFETEYPKAVGNGWTVKNVADAFNMEWYLNSGKGNNDVVTTMSVAGTLTTATPTNTSTYVASSTAASSASVTDSAGVSIASAASSEASSSWAIANRPSHFVIAIACGLALAAIMV
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsilon-amino group of Lys-170 at the active site.
Sequence:
MKPVIVKNVRIGEGNPKIVVPIVAPTAEDILAEATASQTLDCDLVEWRLDYYENVADFSDVCNLSQQVMERLGQKPLLLTFRTQKEGGEMAFSEENYFALYHELVKKGALDLLDIELFANPLAADTLIHEAKKAGIKIVLCNHDFQKTPSQEEIVARLRQMQMRQADICKIAVMPQDATDVLTLLSATNEMYTHYASVPIVTMSMGQLGMISRVTGQLFGSALTFGSAQQASAPGQLSVQVLRNYLKTFEQNK
The following text describes a protein:
Function:
Antimicrobial peptide. Has low activity against the Gram-positive bacterium S.aureus (MIC=12.5 uM) and the Gram-negative bacterium E.coli (MIC=25 uM). Has weak hemolytic activity against human erythrocytes.
Subcellular Localization:
Secreted.
Sequence:
MFTLKKSLLLIFFLGTINLSLCEEERNADEEERRDDLEERDVEVEKRLLSLALAALPKLFCLIFKKC
The following text describes a protein:
Function:
May function as a negative feedback regulator of TOR function.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MISMGMTSKGQNVDGAPAGNSSSEWIISSSSSPFQANKRYSLDPPFGSDYSPPASPQNELDPLSSYFLNLQSEDNDVRKTAIEYIINTLSNPDNEKLIKNHLPMIVVLSTESPFDDISEAFTNFLKPIQEKYHIPKQRTTVFTSESQLPPLNTDDELTRKLFQDVFLQHGRVNHLTRILGWHPQYLEKFLLAYNTIMRDPGPLPLHWRNYIGILAAARYKCSYIIALQEHEFLMNNGDARWLQGIDHIPAKLKNLLKVIELLAHQPWLLPKLDIEYLVKGTDAWSIAELVHAMVLICTFLSLSGFVFCCGISPECGLSESNNLSSSFSLNDSDCEIEDTAATENTAKVMELLKNRRSQQQDDDDDDQLHDRQQDFHNAGDDSQSSNNNTTTTTTTTTTTTTTTNTNTTSNSAGGGDSSSSTLSQSSDRMSDFSRYIGNNTMTHTDFDVSSKLYNIFSAQEYSWREHGYELVSRYFPDAAPLLDEEFSFVYTMTYYKFNNNTDIDTLPFRRAVWYYVQRVKGMLHDDYNYQEVNMFLSRSLKNFVKKAVCFPETIKRDDYSKLGYSLKPDEKCHLSLLAVCSHKQASLLYGLYSVMNYQNRR
The following text describes a protein:
Function:
Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively. The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain.
Subcellular Localization:
Nucleus. Note=Localization is diffuse during mitosis. Co-localizes with SMARCA5 in the nucleus.
Sequence:
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQL
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium.
Sequence:
MSRSNSVSPPGVGAPGLRGGTEHRSAWGEAESVANGCPYSVRSPRKKLTRTNSRWREEDEPDNRPPGRASTTVSRVSFRSRSAWQDHGEEKPEDNRASAKRTEGEVRPKSVELGLEERRLKSRGDEEEVMPEVNFSLVACCVGVMHIFKSKKFQSEKLERLYQRYFFRLNQSSLTMLMAVLVLVFTVMLAFHCAGGPAGPSVTYVVVFSLAIFLTLVLMVICNRNGFHQDHMWVVCYVVILVVLVIQVIGVLLVQPRSASEGIWWTVFFIHVIYTLLPIRMRAAVITGVILSAIHVAVSWMLNGMDSFLWKQLVSNVLIFCCTNIVGVCTHYPAEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKDDINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGLDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANQMEAGGQAGRIHITKATLNYLNGDYDVEPGAGGERNAYLKRNNIETYLIVGCSQKRKEEKAMIAKMSRQRTNSVTHNSGHWTDRPFYNHLGGNQISKEIRRMGFDDPKDKHFIFRNAQENLNPEDEVDEFLGRAIDARSIDRLRSEHVKKFLLTFREPDLEKKYSKQVDTRFGAYVACASLVFLFICFIQIIIVPRSTLMIGFFITCLVILMSVMFISTVYYCFGIFPVSLQTLSKRIVQSRLNSTLVGVFTILTVFLSAFINIFTCSSADLRSCIGSGLNVSVDSVNPCHAVSLNYSLDPRHTPCGEGALVCNFPEYFSSCVLLSLLASSVFLQMSSIGKLFLMLFIELLYLLIMEVPKVSLFDNQDLLVMANAFSSLKQMNGTSCVADTKVPLKIMTPVVITVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLQRERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDQFRQLEKIKTIGSTYMAASGLNDSTYDKAGRSHIRAMADYAMRMMDQIKIINEHSFNNFKMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTDLYQVLSSYNYTLEYRGVVTVKGKGEMMTYFLTGGPSS
The following text describes a protein:
Function:
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Golgi apparatus membrane. Postsynaptic cell membrane. Vesicle.
Sequence:
MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGMDVNGRYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS
The following text describes a protein:
Function:
May act on PRP20.
Miscellaneous:
MISCELLANEOUS: Present with 1270 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTLDYEIYKEGGILNNRYQKIEDISEGSYGYVSLAKDVREKRLVAVKYIFKLEDDGQYDGPQDDENDCDSSDCDDDEDTKVDTDRHENENGNASSNNGSSREKKHNLYKHKKSLISSKVKSRLSNNICLEAMYEVDIQTKIGRHQNIAALLDFFDSYIIMEYCSGGDLYEAIKADAVPKKTKSITHIITQIMDAIEYVHNKGIYHRDIKPENILISGIDWTIKLTDWGLATTDKTSMDRNVGSERYMSPELFDSNLDIKERKEPYDCAKVDLWAMGIVFLNIVFHKNPFSIANQSDKSFCYFAANREALFDVFSTMAYDFFQVLRYSLTIDPANRDLKMMRTELQNLSEYTLDDEYYNNLDEGYEETMIDGLPPQPVPPSSAPVSLPTPISSSNKQHMPEFKKDFNFNNVNERKRSDVSQNQNVASGFFKKPSTQQQKFFNQGYNTTLSTHERAKSAPKFKFKKRNKYGRTDNQFSKPVNIEDRKKSKILKKSRKPLGIPTPNTHMNNFFHDYKARDEFNTRDFFTPPSVQHRYMEGFSNNNNKQYRQNRNYNNNNNNSNNNHGSNYNNFNNGNSYIKGWNKNFNKYRRPSSSSYTGKSPLSRYNMSYNHNNNSSINGYARRGSTTTVQHSPGAYIPPNARNHHVSPTNQFLRVPQSTAPDISTVLGGKPSYQEHYTQDSMDSEGDHDSDDVLFTLEEGDHDFVNGMDNLSINDHLPHTTVGSHNEVFVHASTNHNNNGNNNHIDTNSTTNQYHRQYIPPPLTTSLHINNNNNESNELPDLLKSPASSEAHLNLSSGPIDPILTGNIGNRYSHSSDSKELEQERRLSMEQKFKNGVYVPPHHRKSFNLGTQVPPMNMKTSNEATLSVSHNSVNFGGSYNSRRSSANESNPLHMNKALEKLSSSPGAKSSFVGFPKPLLPRNHSSTTIALQNEDVFADSNNDAIIFEDEEYEGESDKMAHGKMEGGDNESSSTSPDERQIFGPYEIYAQTFAGSTHDKKLGAGRKTSIQDEMVGSLEQYKNNWLILQQQD