lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum.
Sequence:
MSIENSVVVPAYHERPNIKPLATRLFAALGNADSKKTELIFVDDNSQDGSVEEVEALAKQGYNVRIIVRTDERGLSSAVLKGFYEAKGEYLVCMDADLQHPPESVPLLLDSLRTHPFVLGTRYAPGVGIDKDWPLYRRVISSSARMMARPLTTASDPMSGFFGLQRRYLVNDDAKGINSEGFKIALDLLVKLPLPADRPIGEVPFSFGLRTEGESKLSGKVIVQYLKQLRELYAFKFGTSNLFLFLFFWAILAVYLFIQLASALA
The following text describes a protein:
Function:
Involved in the degradation of heparan sulfate.
Subcellular Localization:
Lysosome.
Sequence:
MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYPRWVAGSW
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).
Domain:
The activation loop within the kinase domain is the target of phosphorylation/activation by upstream protein kinases. The PPI motif mediates the interaction with the ABI (abscisic acid-insensitive) phosphatases (By similarity).
Sequence:
MFRSMGTGTGTKPPAMTTERYEFGPLVGEGNFAKVYLGRHRATGEEVAIKVMDKEKLVRLGATELIKREIAVMQRLRHPNVVRIHEVMANKRRICVVMEYVRGGALYRYFRRGPSGGAAGLREHEARRFFQQLVSAVAYCHSRGVFHRDIKLDNLLVDEQGNLKVADFGLSALADMERREAHLQTVCGTPLFLAPEVFKRRGYDGAKADVWACGVVLYVLLTGRKPFPDEHVSRLYRLIGQNQFQCPPSFSPDLARLVRRLLQPDPDRRITIPEIMEMRWFKRGFKEVTYYIDSNDRLRSLDGLDGEPELYDSDTDTIESSSSSESPTPVAGTPRGMHTSVSAPALSELDRMEDSASLPLPLPLPPRPRMPRPKSLNAFDIIASSPSFDLSGLFEERGERMRFVSGAPVADIIAKLQEIAGMVSFTARTKDCQVSIEATRNGQKGALAISAKVFELTRELVMVQVCKKAGDTAEYRRFCDNELKAGLRGLVVDALPPPVEGGGHGGAAAAAEAE
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNHPVRFQNPSVDENLFLWFIRATLTSGGFGIKLDKLLQAVGARDLQALNHYNGVEGLSTLLKTDLERGIDDEIQQRKQAFGSNTYPSKKGHTFWSFIWKATLFPPYMAILLATVLNLLLRIKGKAIHGSWYVEACTILAIVPYIIVTASTEYMQSRQSEKISEEKRNVALDVIRGGRRFTVSSSDIVVGDIVPLKNGFQVPADGILFVANSLKIDEQELTGSHLIVQKDILKDPFLLSGSKVIEGIGTMLVTSVGINTEWGKKMEKQHETDEEKPFQVYLKWLAISASLLVILLASVACIVQLCRYFFGRTKKSDGTPLYMPGNTSFDEAMDFVIKSLSFGIATILVTVPVGLYVAVLLNLAYTTGEMITDKALVQNLYACERMGYVTTILCHKTGILTKNKASMSVVDVWAGGIRMQDMGDVSQLPSILKELIIEGIARNTNGSVVFETGVTEPEVYGSPTEQAILSWGNKLGMKFDEARSGSPVLHVIPFNPKKKYGGVALQIGTRNHVHWKGSAKVILNSCKWYMDKDNKRIAIDEQKQEMERIIKDMSMRGMRCAALAYQSYELGTLPTTDEELSTLPQDLVLLAIIGIQDPCRSDTKNAVKLCNSGGVKVRMVTEDDVSTAQAIATDCGILENSDDPDVITTGAQFRVLSDLDREEKAPKILVLAQAFPKDSLLFVEALRRSGHVVAATGMGIHDTMTLRAAHVSLAMGVGGTAVAKENSDIIILDDNFDTIVKVIRWCRYLYTNIQRYVIFRVTVSVLAVAICVIEVVFYDAFPLNAVQLLLLNLIADIFGALALAYGPSARKLMGKPPVGESDPLITKTMWFKMVIQVIYLVQLALIHSDSVLKLDHGHTGDAEKVKNTFIFNSLVFCLVFNEFEIRSGEQTLTEVLEDNMFIFTIMATIIVQIISVEFFGIRLDMKKWIISILEGFISQVATRFPLKVYPYRRN
The following text describes a protein:
Function:
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Subcellular Localization:
Nucleus.
Sequence:
MNSDIPDPSDWIDSKLSGLKDVDETLRCHICKEFFTAPMITGCGHTFCSLCIQRYLTNTSQRCPTCMQEQQISQLRKNVTVETLVEHFSAQRATILRVVKEAAKQPIPEVVEPPSSPDLDDGRRRSGRKRTRTNYTETLVSSDDIQVECPVCQAMLPGAAINRHLDNNCNDTGANGGNWLGTKKKTKPLRKIQRVNQASESVANVRRKLQDEGLSTSGSKQTLFRRYDEWVTLWNANVDNKTPRSKSDIKDDLRRWETTVVANENAQPVKMTIKNIDDRQWVQKHKEDYDYLIEQARKSILKKKQEKEKEQQQQQEGHQKAVDRREDNEPDMKRSETEGYQVVS
The following text describes a protein:
Function:
Metalloprotease (By similarity). Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed.
Subcellular Localization:
Secreted.
Sequence:
MRLCHSIILFNSLISISICSKADDPALLVASEFKEHFNVEEKQLETVEELLIKMKKLAHSRSFKGREFGHDAVEDSKKEVAISTQQGTINKKVSPFLFEGDIFLSRRQAVDILKALSKDKTKRLRRSFVSDKTATWKTMPIKYRFHESIDFYTISQIIAAIRFWEDSTCITFENVSDSPDGDYIEFFSGQGCYSMIGRNGGRQGISIGESCVKMGVIEHEIGHALGLWHEQSRPDALGYVTIERDFILPSYISDFLQRDDEIDTLGIPYDLGSVMHYGSTAFSVDQKSKTVVTRDSLYQQTIGQREKLSFYDVATINTAYCKDECKSEKTKCENGGYMRPSKCSECLCPDGLGGEKCEKNEDSKNAECGGIIKLTEEWKEIESPNYPDPGYEADQKCSWLLKAEKGKRVEIEFIEDFSFLCTSTCVDFVELKISDDLRNTGFRFCCYDKPEISFVSQTDTAIIIFRSQLSTDIGFKIQAKSTDAEPRTTIAPTIITTTLAPITVDAPNVWADWGEWSMCSRTCGGCGIRSRVRSCRSKKCEGRRQEFGTCNLKACPVDKHCAKLLSNNRLCNGKVCTKNDIAISSCDAPQCCPPFINVDGVCQSDQENQHDELWLSI
The following text describes a protein:
Function:
Involved in the regulation of systematic glucose homeostasis and insulin sensitivity. Involved in the regulation of liver lipid levels by positive regulation of hepatic lipogenesis and negative regulation of fatty acid beta-oxidation; via downstream transcriptional regulation of CPT1A and hepatic lipogenic program gene expression. May regulate hepatic lipogenesis and fatty acid beta-oxidation in an autocrine or paracrine manner.
Miscellaneous:
MISCELLANEOUS: May be involved in the development of hepatic steatosis during obesity.
Subcellular Localization:
Secreted.
Sequence:
MKSLLLTILLLGLVAVLKAQEAPPDDLVDYSGIWYAKAMVHNGTLPSHKIPSIVFPVRIIALEEGDLETTVVFWNNGHCREFKFVMKKTEEPGKYTAFHNTKVIHVEKTSVNEHYIFYCEGRHNGTSSFGMGKLMGRDSGENPEAMEEFKNFIKRMNLRLENMFVPEIGDKCVESD
The following text describes a protein:
Function:
Mannose-binding lectin.
Miscellaneous:
MISCELLANEOUS: Its activity in situ is unknown, however it acts as a viral entry inhibitor, inhibiting HIV-1, HIV-2 and simian immunodeficiency virus (and some other viruses such as feline immunodeficiency virus, measles virus and human herpesvirus) infection and replication. It prevents essential interactions between the envelope glycoprotein and target cell receptors by binding to carbohydrates on viral protein gp120 and possibly by other mechanisms as well. Addition to cells must occur before or shortly after virus addition. It also inhibits cell-to-cell fusion, and virus-to-cell and cell-to-cell transmission of a viral infection; MISCELLANEOUS: Is remarkably stabile; the protein can withstand multiple freeze-thaw cycles, dissolution in organic solvents, treatment with salt, detergent, H(2)O(2) and boiling without significant loss of anti-HIV activity.
Sequence:
LGKFSQTCYNSAIQGSVLTSTCERTNGGYNTSSIDLNSVIENVDGSLKWQPSNFIETCRNTQLAGSSELAAECKTRAQQFVSTKINLDDHIANIDGTLKYE
The following text describes a protein:
Function:
Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.
Sequence:
MGGGLIERYVAAMVLSAAGDTLGYFNGKWEFIRDGETIHQQLAQMGDLEAIDVARWRVSDDTVMHLATAEALMEAGQSPDLPRLYSLLAKHYRDCMGDMDGRAPGGACMQNAMLLQPNRADGYRIPFNSHEGGCGAAMRAMCIGLRFPHPSQLDLLIQVSIESGRMTHHHPTGYLGSLASALFTAYAVNGKSPWQWGKGLMEVLPEAKKYITQSGYFVKENLQHWSYFEKEWEKYLELRGILDGNSAPVFPQPFGVKERDQFYIDVSYSGWGGSSGHDAPMIAYDALLAAGDSWKELAHRAFFHGGDSDSTAAIAGCWWGVMYGFKGVNPANYEKLEYRQRLEEAGRALYSLGSKEDPVLDP
The following text describes a protein:
Function:
Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (By similarity). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins (By similarity). Also implicated in tumor cell metastasis.
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cytolytic granule membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (By similarity).
Sequence:
MAAPGARRPLLLLLLAGLAHGASALFEVKNNGTTCIMASFSASFLTTYETANGSQIVNISLPASAEVLKNGSSCGKENVSDPSLTITFGRGYLLTLNFTKNTTRYSVQHMYFTYNLSDTEHFPNAISKEIYTMDSTTDIKADINKAYRCVSDIRVYMKNVTVVLRDATIQAYLSSGNFSKEETHCTQDGPSPTTGPPSPSPPLVPTNPTVSKYNVTGNNGTCLLASMALQLNITYLKKDNKTVTRAFNISPNDTSSGSCGINLVTLKVENKNRALELQFGMNASSSLFFLQGVRLNMTLPDALVPTFSISNHSLKALQATVGNSYKCNTEEHIFVSKMLSLNVFSVQVQAFKVDSDRFGSVEECVQDGNNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHAGYQTI
The following text describes a protein:
Function:
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
Subcellular Localization:
Nucleus. Cytoplasm. Note=When in the nucleus associated with chromatin.
Sequence:
MAIDYSKWDKLELSDDSDIEVHPNVDKKSFIRWRQRDIHEKRAVRKQKMEDIKGAMAMNRRLLSRISEMETVLEKESPSDPYVLLGSFLEAKKSEDMDSAIPGGMSYHHMLMSLLKVIKDAEDTTEEKSMDDSDKCLRRLKSHKERLLKLLEDAQKEYDTLEAESKNYITSEDLHLGFDSTYVQKKEPEKPKKTKTKKETIQVIESLNNPTPPTDFPGAKEQASTGNAPKNPVNENESEDEEGLSLSEDGKKFANIDFGDYSSSEEFLKEHLNILADEEESDAILLEAFNAELEGKPSLAKQYVHQALLISYCRQLGPNGLSIFFQKIKDPNHQSQRLFLEDVHNTYVRIHERSAAISKEQAESGEGVEQIQLCAVDPNTKLSITIPEAGSTDPETQKARAAFESFPPNLQKALMTNDLDKINVVLGKMAVENAEEVVEKLSSTGMLSIEEGIIDTTKGETIPQLS
The following text describes a protein:
Function:
Nonessential protein kinase.
Sequence:
MSQNIQIGTRKRSRANMNNSTTTGPANNTSSNKTFLDNFEETRTNKLLDEMFARQNSFLTDNLRNSLDLNQADNPLRPRQHQHQLFLDNENAIELDEEPRIINTTINNSNNHNSSRVDEDADDDIIFIKEQPIQFSSPLILPSSSSINNNNNIVTSNNPGCGTAATSNSTYITTPKKFKKQRTISLPQLPLSKLSYQSNYFNVPDQTNAIVPRVTQTENELLHLTGSCAKTLEGNKAVNLTIAHSTSPFSNPPAQIASLPQSNLKKQIGSSLRKFTSNGSSESASSNKSNFKTDKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSPSDLNSTVIKHFDRKTLSLQWPEKNKRGDTITTEKSMKRVLQSCDRLDIYISKVLKQDYGDSLSINWNLPPEKNWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALDHEWFNLGILDDGIATYNNTQG
The following text describes a protein:
Function:
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPAKQRMRLANEKHSQNVQTRGNVPKSLKPAEEKYAVGPILLGLFIFVVCGSAIFQIIQSIRMA
The following text describes a protein:
Function:
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').
Subcellular Localization:
Nucleus.
Sequence:
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDDKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPTAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHSSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTTGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTTDKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPSSQSQPSGS
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (nfya-2-NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types. In association with the components in the nfya-2-NF-Y complex, may repress the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues.
Subcellular Localization:
Nucleus.
Sequence:
MNPRGNPSKMPTQIVLNRRPAAPARPQTTFTSLSQYHMYNTASTSSAPPPPPNQNFGQIREAIRTTQPTTVQLPPDCKLVEYTWQENGESRTVLIPMSNDSTEDDVRSALPQSVLESINQHQNQLRQGNAQAVHYYQKHQNPISHEKPIMVNPRQYKRIIKRREMRQKMEDSGRLPLERQKYMHESRRQHALKRRRTGGRFDANAEAAAASSEPSISSAAPSPPKAPRAPTTYAMIRPATSHPPVNIPKAPAMTYRPVQEEKKSIERISKAQMFTIPKRQQ
The following text describes a protein:
Function:
Involved in the transposition of the insertion sequence.
Sequence:
MKLGSLFGRPKTLASSKKQVPVKESKLAVEMEKKKKPGQFDIVWPKVEPQQVKDYKAILTVSELKKYLERCIQTGKVGFDWETAASKEIRVHYKKAFEDIEEARTTGIIDDKEAESRSESLEKAYLKTPLDPWKGEICTVSLSAAAHESRVVPISHKVGQVFEPSMDRDEARKLVLDLLDEYLFKNEKVLKIAVNLSFETKYAAKYGKYILGKVADPLIMWVRCLQIAAPQKINNPKKPTSGWGLKPATKHIFGVTMNDFSALLKKYKVNFFDEIDASKGEGLLYSAEDSDYAVQHYEYWSQIAAQISRYEEWLHKIEMPFTRVIGLMEYWGMNWDPNLATQKKQEAEIMQEQAAERIKQIAKETFNIDINTGKSGKTNEVKSLMFDYLKIPIAKYGKTGASLDQEALIDMAFMLENKLNDIDEEKYLGVSLPENWENIDPEKDPTLDKLERGAIRIAKREPHPYKEQALEVIDQLKKIQKYTTLLSSHIIGREKYLNFMSGRIHAGYSPFTETGRLNSFNPNGQNVPRPDNDEFKIRNFFVPKPGKILFFIDFSGFELRLMAWKSGDEVMTELFNTGGDMHRRTASVMTGKSEAEIVKKERTDAKAGNFGISYGGTEHALQFTFKTKYMIRKTLDECAQIVNAVKTAYKRIPEYQRKIVLEAREQGYVQTIYGYMRLLPGINSANRRDRGSAERQAANTPVQGSAADIMKKVQNEIYESIGKQEGVLSHGSADMIAQIHDEIIFEIDDDPEIVVAVEKQIKQVMEQPPVPGFPVPIEAEGSVGYRWGEKMSVESWLKQREE
The following text describes a protein:
Function:
Probable receptor for neuropeptide ligand nlp-9 that plays a role in octopamine signaling and specifically, the octapamine inhibition of aversion responses in olfactory sensory neurons. In AWB olfactory sensory neurons, required for the detection of preferred food sources.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSFYNEAKFLISDGEQMRIDTYAVGRKTMQQSDAFKGTFYENFTLVYALPLSNHDNSSLMLIAGFYALLFMFGTCGNAAILAVVHHVKGQDPRSRHNTTLTYICILSIVDFLSMLPIPMTIIDQILGFWMFDTFACKLFRLLEHIGKIFSTFILVAFSIDRYCAVCHPLQVRVRNQRTVFVFLGIMFFVTCVMLSPILLYAHSKELVMHEKVDLDQEVITRMHLYKCVDDLGRELFVVFTLYSFVLAYLMPLLFMIYFYYEMLIRLFKQANVIKQTLVGRRSGGEEKKLTIPVGHIAIYTLAICSFHFICWTPYWISILYSLYEELYQDTKSTASPPTYAFIYFMYGVHALPYINSASNFILYGLLNRQLHNAPERKYTRNGVGGRQMSHALTTNTRPEYSELIAIPSSSCRPDSRVSAMIHNNNNNTESLPLAQNISNMTNKDSATIVPMPMSANVDGNEIYNWITPDTESVIL
The following text describes a protein:
Function:
Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine. The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=Located at the basolateral membrane in the small intestine enterocytes, kidney proximal tubule, thick ascending limb and, to a minor extent, of distal convoluted tubule epithelial cells.
Sequence:
MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTEPENVTNGTVGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVDLEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQKTVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV
The following text describes a protein:
Function:
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3'. Acts as a transcriptional repressor. In both females and males, functions downstream of tra2 to regulate the development and function of certain sex-specific abdominal neurons, and likely regulates the development and/or function of the nervous system that controls courtship behaviors involved in the recognition and response of adults to appropriate sexual partners. In males, promotes abdominal motor neuronal innervation of the ventral muscles of abdominal segment 5 which is required for correct abdominal curling during copulation. In females, also promotes abdominal motor neuronal innervation but on the uterine muscles which is required for egg laying.
Subcellular Localization:
Nucleus.
Sequence:
MGTAGDRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLAKCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGPAPPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEMKTIQEILCRFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARLLRDMYTMEPAQVDK
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVRLREIPRTATFAWSPGPTQPLIATGTKAGAVDADFSNDTQLELWELKLDDAEQGVELQPVATVSVDSRFNDIAWSQPSEQHPRGIIAGALDSGALVLWDAEKLRTGASDAQIDQIDKHTGPIQAIQFNPFRPNILASAGAKGELFVHDLDDESKSFRLGKAGANPDEYTTLDWNKKVAHILATGSSGGFVTVWDVKGKKENLTLNHFGRKTVSAVSWDPDVPTRLVTAIPTDQNPLVLAHDQGVLSLSWCPQDSDILLSCGKDNRTIAWNPHSGEQLGRISGRDKLDLPDQIQPVEPEPYSRPASFDGKIAVQTLQNTGANADQSKTAKQAPEGEDFFAQTHAEPQGASFSLKSPPKWLKRRAGVAFGFGGKLVRFGVVDAKSKITISTFAVDSDISQASEDFDKALETGDLTSILESKISKAATDEEKADWTVIETLTSDNPRTKLVEYLGFADQSEEAPAEVKKEAQTNGDADEGSSFFDNATDEGNFLSDLAARKGAKTNNPFQVYTGSESEADTKITRALMLGNFDAALDVCLKENRLSDAFMIAICGGEKCVAKAQAAYFKRQSDAPNYLRLLASVVGKNLWDFVYNADLKDWKEVMATICTFADQAEFPDLCEALGDRLEEAIAEGTTSYRKDASFCYLAGSKLEKVVVNWAQELQENENAGLEQSETDNSFSIHARSLQDFIEKVTVFRKVTQFKDTEQSKENDWKLEPLYAKYVEYADIASAHGQLAIAEKYLDLLPQKYPAADVARNRVKQATRKGAAPAAAGQRQSQPAAAQRGQRVVPAYGAPAPQPTPAQRTASPYAPANPLAPAQTNSPYAPVNPLSQQAQQATQQPPARAGGAYTPAGYQPAPVQQGYGGYGQQQQAPLAPPPQNFSNPNGPSIVPAANRGHIPAWNDTPDFGPPKTASRRGTPLNAVASPFPNQQQNYGPPGGASPGFPPQSRPTPPPPPKGPPQGPPRMTSPPSQAGGAPPNAPNPYAPSPAANNYAPPPSGFAPPQQAPVQRGASPYQPPQSAAPPSNRYAPAPGSQPSAPSGMGGMPPPRNIAPPPGQFTPGASAYAPSPYAQSPAQQAPAAVAPPPRGPPQGPPRAGPPPGGPPQGGPPRPESRPGTGQSQPAAPAAARYPPGDREHIPMVSRPIYEILGAEIQRVKAKAPAQYKAHVTDTEKRLNILFDHLNNEDLLKPDTIQQMNELASNIQAKQFDEAIAIFQDLMTNKNDEGSNWLVSDVITFDADVGVKRLIQFSKSTPA
The following text describes a protein:
Function:
Ribosome-dependent ATPase that functions in cytoplasmic translation elongation. Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity). Assists translation termination by stimulating the release of nascent protein from the ribosome by release factors (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPPKKSNARNASLLKEAVTNAGRSDTASTAREGSIAATFVSDSDSSTTASGPVDEKVAAVAELITTLTTNAASDKRQSAADDIAKFVEAEGVAQMVKTKILHGIATGLHNTKQPVAREGAITAIETLIKSPVSKQIEPYMITFIPVLLERLSDKAKTVCLAADSALKALITRLTPYATKQVLPLLLAGIEYSQKWQTKVGALELMQSLSKTAPRQMTTAVPDLVPPLSEVMHDTKAEAKNAGRQTMEAICELINNKDIEKFIPALIDTIANPEKVPDTVHLLGATTFVSEVLPPTLAIMVPLLSRGLNERQTAIKRKAAVIIINMCKLVEKPQIIAPFLPRLLPTLEKIQDDVADPECRQVCQNATKILTKVGIPAPGTVMDDSYEFKKLDDKALAYLKKAIGHQQITEIPEAYRPVLEYLEHIAAAMVADGNMDNDDWNGSIIPTLKAFIPTEGTVTNAVKEFRELSFGSNVKEAVAEEEEDDAEELCNCEFSLAYGARVLLNRTHLILKRGHRYGLTGANGSGKSTLMRAIANGQVEGFPPADQLKTVAVEHDLDGAHEHDNKEVQAFVLEDPVYAHLPKETVVNMLESVGFKGPMATRPVGQLSGGWRMKLALARAMLHNADILLLDEPTNHLDVINVAWLQDYLIGLKTVTSIIVSHDSSFLDIVCSDIIHLDNFKLKRYRGNLSKFVEAVPEAKAYYELGAAQQTFRFPEPGMLEGVKTKERAILKVQNAVFQYPGTDRRQLNGVTFQCSLGSRVAVVGPNGAGKSTLIKLLCGVIEPDNGVVWRHPNLRIAYVAQHAFEHIEKHTNLTPNQYIQWRYQTGEDREEMEKAARQISAEEEAAMKKVQVISGEKKVVDSVIGRRKLKNSYEYEVSWVGKLSNENSWLPRDTLIEMGFLKKVQEIDQAEAARQGLARPLTQKEIEKHLSDVGIDSEIGTHSHIRGLSGGQKVKVVIAGAMWQRPHLLVLDEPTNFLDRDSLGALKTAIDAYGGGVIMVTHSREFSEAICKEVWKVDNGELTPTGHNWVSGQGSGPRLEDKNKDEEVFDAFGNKIDVAKQKSKLSGKDLRKKRKEREARRKRGEEVSDDDE
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the riboflavin precursor 5-amino-6-(5-phospho-D-ribitylamino)uracil and of flavin mononucleotide (FMN) in vitro.
Sequence:
METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCISTGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISESYNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEEDVPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAFGDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL
The following text describes a protein:
Function:
Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Golgi apparatus membrane; Single-pass type I membrane protein. Midbody.
Sequence:
MWLRTLTVFFPFVAGSCLGLKVTVPSHTVHGIRGQALYLPVHYGFHTPASDIQIIWLFERSHTTPKYLLGSVNKSVVPDLEYQHKFTMMPPNASLLINPLQFTDEGNYIVKVNIQGNGTLSASQKIQVTVDDPVMKPMVQFHPASGAVEYVGNITLTCRVEGGTRLVYQWRKNGKPININSSHSFSPQNHTLRIVPATKEDIGNYTCLVSNPVSEMESDIIIPTIYYGPYGLQVNSDKGLKVGEVFTVDLGEAVLFDCSADSYPPNTYSWIRRSANTTRVIKHGPRLEVASDKVAQKTADYVCCAYNNITGRRDETHFTVIITSVGLEKLAQRGKSLSPLASITGISLFFIISMCLLFLWKKFQPYKAIRQKLEGRPESEYRKAQSFSGHEDALGDFGIYEFVAFPDASAVPRMSSRSAPASDGVTGQDFQGTIYEVIQHIPAQQQDDTE