lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.
Subcellular Localization:
Cytoplasm.
Sequence:
MQLQSPFGDGISCECLNIRVLGIPNETKHQWIFVPRDLIKIKIYSLLQICKAENCSAVACRGCNLCILAVQGNIEISEEPQKLFQEENVKVYIYDSAISLSSVRASFPISELGIRMDIIKARAEPREDEIRASFSSLVNKEIKRTVEELLLSKRSTNRLSLLAFMRNQQLNYEAYETKLLEDASTIEKSLEKEVKTIYDSNIASPKESSDAIDADHAMIDESRSTQRRKSKPKKHVAFTDEYQVAFSDKPGKYFNQPMQYSKQFKLDNPDYEASSDSLNDIENLSTLTFRSDEELEFDFDTNNINNNKSGDSLEMSTTIPSDEENEDFTSKVDAMEIHSGSLPLNIDSSPIFTNHSPSSSLSSESSFEASPSSFVDRKNRWIQMLKKADEHSRSIQARSMGYVLSDDLDNSKAFRPYKQSFLAQGWKSLN
The following text describes a protein:
Function:
Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles.
Subcellular Localization:
Nucleus.
Sequence:
MEASRNRSLVGNNRSPEMNENDGEDVAASAAVEDVEVWDTLSNGFKRAQLYLDQNRDLIQRVNENHMSRIPDNVSRNVGLINEINGNISQVMEIYSDLSLNFAKKFDQRRRTTKDGDTTTTTTGS
The following text describes a protein:
Function:
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Subcellular Localization:
Nucleus.
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
The following text describes a protein:
Function:
Probably an atypical receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta-like daf-7 signaling. Plays a role in TGF-beta-like daf-7 signaling in regulating entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions; partially redundant with R-SMAD daf-8.
Sequence:
MSNEQEDFGSLFNNQGELGIMDDFAEFGFQTTTTPTNWAAAGNYMYPDQVHLPASINNPNMPINDWLEDAPMPDCYNVPSTSTDENNDPFPFSNISSQSSLKPKTPEKAVVEVRPTGNEMLDPEPKYPKEEKPWCTIFYYELTVRLGKAFEAKVPTITIDGATGASDECRMSLTSQPSSRNSKSSQIRNTVGAGIQLAYENGELWLTVLTDQIVFVQCPFLNQTLNKPLKYVFRLQNKGDQKRMKIFDKEQFEQEKTLALGPLTEKEVADERMRIFSNIRVSFCKGFGETYSRLKVVNLPCWIEIILHEPADEYDTVFRINNERPEIGSRS
The following text describes a protein:
Function:
Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity.
Subcellular Localization:
Secreted. Note=Secreted in an Xcp-dependent fashion (a type II secretion pathway).
Sequence:
MKHYSATLALLPLTLALFLPQAAHAHGSMETPPSRVYGCFLEGPENPKSAACKAAVAAGGTQALYDWNGVNQGNANGNHQAVVPDGQLCGAGKALFKGLNLARSDWPSTAIAPDASGNFQFVYKASAPHATRYFDFYITKDGYNPEKPLAWSDLEPAPFCSITSVKLENGTYRMNCPLPQGKTGKHVIYNVWQRSDSPEAFYACIDVSFSGAVANPWQALGNLRAQQDLPAGATVTLRLFDAQGRDAQRHSLTLAQGANGAKQWPLALAQKVNQDSTLVNIGVLDAYGAVSPVASSQDNQVYVRQAGYRFQVDIELPVEGGGEQPGGDGKVDFDYPQGLQQYDAGTVVRGADGKRYQCKPYPNSGWCKGWDLYYAPGKGMAWQDAWTLL
The following text describes a protein:
Function:
Lectin that binds sepharose in a calcium-dependent manner.
Sequence:
MAMLTISLLLCAAVALNGATVLELFQDFEQALHLGAKGEDERVVAAENRNQCPTGWFQFGSRCFMFVETARSWPLAERHCVSLGANLASVHSSAEYQFLQEVVASKTGGFSTPWIGGFDAVQDRLWFWSDGSEFDYQNWKKGEPNNSGGREPCIVINWRDEYRWNDINCGNSFPSGVLQKNVEIQKNEPT
The following text describes a protein:
Function:
Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
Subcellular Localization:
Cytoplasm.
Sequence:
MFMAENRLQLQKGSAEETIERFYNRQGIETIEGFQQMFVTKTLNTEDTDEVKILTIWESEDSFNNWLNSDVFKEAHKNVRLKSDDDGQQSPILSNKVFKYDIGYHYQK
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MITNQVLLLLMLSVLWPSTALPFTTGNIENLFGKPESDGRVLQRSKRGWMWNQFFLLEEYTGNDHQYVGKLHSNMDKGDGTVKYVLTGDGAGTLFLIDEKSGDIHATKRLDREEKAMYTLHAKVLDRNTNAELEPDTEFNIKIHDINDNAPKFAKEIYFASVPEMSEVGTSVVTITASDADDQTYGNSAKLVYSILEGQPYFSVDSENGTIKTALPGMDREVKENYQVVIQAKDMAGQMGGLSGTTTVSITLSDVNDSPPRFANHSFRMAAVESTEIGGAVGRIKADDPDVGRNAEMEYTIVGGHDTFNIITDQMTQEGVVIIKKTLDYESKRDFEFKVEVTVEDVDEPPLFSMNPYIIEVHEDTAAGSFVGVVSARDPDADDKPVKYSIDRHTDLERLFNIDSVNGTITTLKALDREMSKWHNISVVATEINNPRQTTRVPVFIRVLDVNDNAPEFAMSYDTFVCENVKAGQLIQTISAVDTDEPLVGQHKFVFSISASNPNFTIVDREDNTANILTRRGGFSRREMSMYFLPVVISDNDYPIQSSTSTLIVRVCGCDSRGNMQSCNPEVLPFSDGLTTGALVAILLCVIILLMIVVLFAALRRQRKKEPLIISKEDVRDNVVSYNDEGGGEEDTQAFDIGTLRNPEVMETNKLRRDIIPEMLFPFRRTSPIKDNADVRDFINGRLQENDSDPTAPPYDSLATYAYEGTGSLAESLSSLESAATEGDQDYDYLSNWGPQFKKLAELYIGRSPDRET
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Miscellaneous:
MISCELLANEOUS: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTHIVLAALNSLGVMADASGRNDLVVKTPDGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITSVRSRVANLTELLPGITHEQVCQAVTEAFFAHYGERVDAEVISPDKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGVITRAQAFTDSLNPAPLEALAERLQGCLYRADKLQETCEALLVDFPEQEKELRELSAWIAEAVR
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=Enriched at crista junctions.
Sequence:
MVLGFLVRGGLVAATVYYTQKVGIWGDSDQTDKLYNDIKSELRPHVQKLEKQLPFEVPQLPKTGEMRFLAKHYYNEGVKNTFRFIHMLPCYAGRGLKKVKDTFQDFAQSPAIAGGAESSPPK
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
Sequence:
MQDSFDQKKQSILSEISSNSPDNLDASPKGTIDEYCLPIIDTINSHRDMVTTSSCSGRVSIFLEGVKTNNSTSVVAKGHEGRWLFVTHEPKDLNNWYDSIDFNYDTSKFPENASARSILYKFEPLILHVKCRNESMAQKLYVLAMNNGFRESGIGNNFNVAIRINIKLDIPIGFQNVDEEDLNCFVTKEYLKYITDISHERFNENFKKLEQLHRAIERMIEDETKGIETTKKKHKESKEERRQRMIKEGLQRQQELRELKEKQQQEQNETLHVDK
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Secreted, extracellular space.
Sequence:
MTFLAHSDHSSGLASCRPTNSPVSGASLRSCLQLGRCSHFPGRKALLKGLERCLTPAMLALLCAFLLLAAGASDPRAEPSSNTTEQIRDMHAKVTEIWQELLQRRQGGSGRDAALHAACHVQPSATLDAAQPRVTGLVVFRQLVPGAKLEAFFDLEGFPAEANGSSRAIHVHQFGDLSQGCDSTGAHYNPLAVPHPLHPGDFGNFAVRDGHLWKYRGNLAASLSGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGVCGPAPWARQAQQHAERKKRRRESDCKAA
The following text describes a protein:
Function:
High-affinity nickel transporter responsible for nickel uptake. Required for urease biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNSMSEYVKPRKNEFLRKFENFYFEIPFLSKLPPKVSVPIFSLISVNIVVWIVAAIVISLVNRSLFLSVLLSWTLGLRHALDADHITAIDNLTRRLLSTDKPMSTVGTWFSIGHSTVVLITCIVVAATSSKFADRWNNFQTIGGIIGTSVSMGLLLLLAIGNTVLLVRLSYWLWMYRKSGVTKDEGVTGFLARKMQRLFRLVDSPWKIYVLGFVFGLGFDTSTEVSLLGIATLQALKGTSIWAILLFPIVFLVGMCLVDTTDGALMYYAYSYSSGETNPYFSRLYYSIILTFVSVIAAFTIGIIQMLMLIISVHPMESTFWNGLNRLSDNYEIVGGCICGAFVLAGLFGISMHNYFKKKFTPPVQVGNDREDEVLEKNKELENVSKNSISVQISESEKVSYDTVDSKV
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that facilitates microtubule-kinetochore interactions and the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MSTKDTSGQSGYANDIRKLGEQTAHVSEQVLVQQERQRLGALEELHQSIIQIAEENSFVTPIKKDAANVHIDPRGIAVSVQQFKQLAEVLKVTHLEQETLDNFLRYTISDNDQLLDIKSVADSRYARLAEEVCQLEQEELRHLENEIISLNGNITEQTTKVIDANEKVKEECLEVSNGIERCWGLLNELETLRSTTDEGNVELGPLEETYQKWKSVDHFLQQKLHLKEQLRVLEDTRKSLSEVTKSSGNRAPDLDASEKFVTYRLLDSMWKKQFVDTTKIRDLELYPRTGKIQFQVADTIYVLAISGDQISNIQLFNDKLPAADLENNTQDLNKRFLGTSDVRRVVDFITHQQAVPQAQVH
The following text describes a protein:
Function:
Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Binds GGAs; MISCELLANEOUS: [Isoform 2]: Does not bind GGAs.
Subcellular Localization:
Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network. Note=Colocalizes with GGA1, GGA2 and GGA3.
Sequence:
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSALIATEPVDIE
The following text describes a protein:
Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MLALRTLNQRRLMVYFFYLLIICILFYIFIYLGSYYVYSRDKILPAVPVTTDLSKDIRKRESAADNETQETEDEDDELADKTYQGRVNMHVFEDCCGGSLDQLRNNLLYPLFPNVRTSVSRLAVSPQGNSYGLRIFGFLHPAETNEYIFAVASDDNSEFWLSLNKSPKKLQLLAYVGETGNEWTAPGEYWKFATQISKPVLLVKDRKYFFEVLLKQNTGMDHLEIAWSLNQGNSTFSVITSEYLSLYKDESSLLMGDIEHVPQTKASYDRFLEPNPLSLHQREIIREDPRDHIYKYKMLEESFLKDLFPECDYKPSYVLKEHIGRYQGVYLVQFSSVYPNDYTRQTNDQNDGMCFYRQDPSFLADKGLEGYLTEVEDPDVQNTYKGEGPFWHRVYDVNPLNAASKQTTIVANSCRTSGNIVMSESQALPIVTAFLKALHSREDTQGYSLLRVVNVVKREDKDLGSRYLVELELVDPQGQTVLVSRYIYAQDENSSKPALLCSPKAFNWNPSATVHIIVAVKDQARWIIQFIREMEKIYQATGDKNFNVIIVDYNSSDINIEKRLEMAKLPSYKLKKMGGNFERSGGLQAGIDLVEDEHSILFLCDLHLYYPVTIINSIRKHCVEGKMVYAPVVMRLDCGASPRTPNGFWEIAGYGLMGIYKSDMDRIGGMNTVEFKDKWGGEDWELLDRVLGNGLEVERLHLKNFFHHFHSKRGMWVNSNSEKKEK
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Sequence:
MRVIACFIRFVTLNVLMTISGITIKHFAYCPQIVRIESMGFTERVSEAMIEGEQVEKDKVMNFLYATLKPLNVVGKPIFRYGDLIGSPDYVLIYPNHWVPLDVKSGRKRYDHKLQMKYYLYLMDMNGINVKEGLLYYVSLKEMVRLEYNYAEKRYVEKVLSKIREAINGKVRVVQDARKCYNCGFFVYCKPKIKGNLAYVD
The following text describes a protein:
Function:
Presents phospholipase and nuclease activities, depending on the different physiological conditions. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission. Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, this activity could not be confirmed (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein.
Domain:
In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site.
Sequence:
MDVFKQMSFKELMKVLGLGTVAFVLGVEWLNWLTRRLRDSRGPLKEVLFFPSPQVCVEHLFTSHRSFPCACPFPHGIQTSFSRLLEHLLSARTSLEMCIFSFSNMEMSRAILLLHKRGVVVRVVTDRDYMTITGSQIGALRKAGISVRHEMSSAVHMHHKFALVDGRKLISGSLNWTLTAVQSNKENVIITEEPELVRPFQQEFLKLWEASDPANLKLQSKNGQIKK
The following text describes a protein:
Function:
May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity).
Subcellular Localization:
Cell junction, tight junction. Cell junction, adherens junction.
Sequence:
MAKNITDVSRDDLSKVSDEELQKCSKEELLRRLRKVDAEKMNLMLEHGNMMKDVNRRLQLHLHEIRSLKEVNQKLQEDNQELRELCCFLDDDRQKGKKLSREWQRFGRYTASVMWKEVGVFQQKLKELESNQDSVMRENLELKEIIIMLDDERNGAGSRSSIDSQSSLSNLNGGSATVRDVGDGSSTSSTGSAGSPDHHHSHIHKPTEGKITSIRRSMDDLSTNHLLRNIPNGLNDSSSNYIRQLETKVRILEDDNKQLLSQQGSVGDLKTLRKGLSLYHSESQLSSLSQFQDTLQNGSIRIAGGDLAPTVTGYLPAAQKPEAVVHAMKVLEVHENLDRKIPEDYEEDLSEKEKAIVREMCNVVWRKLGDAAGTKPSIRQHLSGNQFKGPL
The following text describes a protein:
Function:
Binds together with bS18 to 16S ribosomal RNA.
Sequence:
MRHYEIVFMVHPDQSEQVPGMIERYTGSVKEAGGQVHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQQVIDELETTFRYNDAVLRSLVIHTKHAVTEASPMKAAKEERKPLAEVENNDFEDAEE
The following text describes a protein:
Function:
Mediates the transfer of lipids between membranes at organelle contact sites.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MFENIVSEVLTRYFGKYISGLNAENLRISLWNGDVTLENLIINESAFDGFLVGVPLKVISGRIGKMSLRFPWNKLDSQPVVVEINDIELVCTTDYDVDPSVISEQLKKEEQESKQRQLRNYEITSDKTTLTQRIITKVINNMQIDITNIHIRYEGVNGWINTKYAIGSVIDSIKLYSTDSQWNPAFVVENQGDHFKIAEIIKMRIYHSQTKEDKWNTNVKKEYIVDDLTTKMRLILSDKDDSYPVTSQIILEMLKVGISQGVMIDVKSLMQQQKLFEGKCSQVGRNVKKPEEGVEQVPKKWWKFAFDSLLIEVKKKNYKESNEYKRKRRALRQEYTDIYTRVLSETTVSGDKERFNELEEELSVKEIIYLRNFAKSEVDEAKSNSSGIWSWMGYSNVVNSQLTEDIHSFLGDDNKEEKVTDTKKLKQVDFSFETKQFIIDLFGSDLNEAFVEVEISSLNCSVVKKTIGFTANIDLNDAKVKSNKDNKYPYIFSAINNEKNLLHIKLTSEKEEEKIDSDFSLDVHLEPTNIVYNKNMAEELMNVFRSLDVVESYGQIGVKLPSMNLKSILDEHIRVVISAMIHAPYIIIHSDNNELHIDLGIVKMLTNERNGIYDSYKLTINEINCKMITDSKSEILLEKTQMSFDIQKALLSWKEMKEKLNEFSPGIIVDCLLDTTKLHISSEQMRAIRLMFKNQKPKPKTEHEAIRDLLQQEDDLTDIGDDAVIQIPEDFIKLKLTVSIPEATAFISLTENEPIFNVSAKQLTMTSIIKDKKSSADISFGDVIVIDNDNMTFFSKKQTNESLVSLHMTNESDKPITITLFAAQSMIYFDLPHLDHILHFLYNDHEQQTVVSIPQKKTQSKVVQVSFVFTSIGLVVRNHGNNNNPEVDITVKGSLKRVFAKDETISGKIHSMVIQTVDTPIDILYTHAITQKAIQQDYRHYLSIKTDQMTCTYLNIFIQQLYSWLQDFLHICSVRVFPSNEPSHSYDRLKLETDITNVSLCIPVASYIEDGIKLIAKQLQVRSTWIQNQQSTKSLTLYDIYFDENVSAKEVTFNFTFPDEKNVAVDFPAWDISLSIPSGYINLTKERYREIVGLIMINLGELSKHQDLIKYHPVVSPNQQELSDIRSRIFTADIGSVEVNVNEEEQIGIMKFDELKYKYLSLPHDCSLHTVEIKSGSFIDHLNKDELLFWVEGQKKIDNFMNFSFETAEKEKIITLSFGHSSHIRLTQETLLKLIKFFSVENKYLITESGFAEVVETTKIQPERAFVFKFLMNEINFHLNDKQGDFMIVSLLKSSIEMKRFREDTNVFLKIGTLKAVSDDKVIISISDEKEMGTFEYIYEKRNELSMFKGNLSQIHIIFYDKVIIRGAQYYEQLVKILSALKGKTVQFIEQTATVSRKIRLNFVIEAPKIDIGEVTAQLGIVTITDKPGTLNKLEIIGNLSNTKVNIDKDEVVKCEGVTMEIEVIDADDGYTDVGIDADCKVIDICTTPQNLTSLLNIADMIIKTSQQIQLPK
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG. Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels. Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo. Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation. Is specific for 3'3'-cGAMP since it cannot degrade other cGAMP linkage isomers (3'2'-, 2'3'-, and 2'2'-cGAMPs); is also able to hydrolyze c-di-GMP but not c-di-AMP.
Domain:
Consists of two tandem domains of about 15% identity and similar three-dimensional topology that interact to form a pseudo-dimeric structure. The N-terminal domain (residues 1-258) plays an important regulatory role in facilitating the catalytic function of the C-terminal domain (residues 259-460). The N-terminal domain alone does not show any activity. The C-terminal domain alone is much less active comparing to the full-length protein. The full-length protein is 13 times more active than the C-terminal domain alone.
Sequence:
MSVAQNTFPLSELMISLTTALDMTEGQPPEHCIRCCWIGMHIGMQLELSEPELHDLFFTLLLKDAGCSSNAARICELYATDDLTFKRRYKTVGTSLSSVINFIVKNTGSEQSWTERILTTIDILKNGNDYAQELIQTRCTRGADVARELRFSEAVAQGIHSLDEHWNGQGRPEQRKGEAIPLFSRIALLAQVFDVFQMEHSIEEALQEIMARSGVWFDPKLVEVVEQLVENPRFLSGLKATDISQRVMNLPPAQAHLPLDDAYLECIVTAFGKIVDAKSPYTAGHSERVAVYTDLIARQLAISDADRIWLRRAALLHDIGKLGVSNAILDKPGKLDEAEWRAVQAHAAYTEQILYKLSPFKTLARMAGAHHEKLDGTGYPRGVNGDEISLMTRIITTADIFDALSAERPYRAAMPIDKALAIMEENLHTAIDPECFAALKKALNLLPDEYTQLPHSSDKT
The following text describes a protein:
Function:
Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (By similarity). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (By similarity). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (By similarity). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (By similarity). May have a role in nuclear receptor-mediated transcription repression (By similarity).
Subcellular Localization:
Nucleus. Note=Localizes to pericentric heterochromatin. May target the CHRAC complex to heterochromatin (By similarity). Localizes to sites of DNA damage (By similarity).
Sequence:
MPLLHRKPFVRQKPPGDLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGLTYQEALESERKARQNLQSFPEPLIIPVLYLTNLTRRSRLHEICDDIFAYVKDRYFVEETVEVIRNNGTRLQCRILEVLPPLHQNGFANGHLSSADGETIVISDSDDSETQSSSFHHGKKKDAIDPLLFRYRVQPTKKEMYESAVVKATQISRRKHLFSRDKLKLFLKQHCEAQDGVIKIKASSFSAYNIAEQDFSYFFPDDPPTFIFSPANRRRGRPPKRISFGQEDSIASKQTAARYRNKAIKERDKLLKQEEMRALAFEKAKLKRERADALEARKREKEDKEKKREELKKMVEEERLKKKEEKERLKIEREKEREKLREEKRKYMEYLKQWSKPREDMECDDLKELPEPTPVKTRLPPEVFGDALMVLEFLNAFGELFDLQDEFPEGVTLAEVLEEALVGNDSEGPLCELLFFFLTAIFQAMAEEEEEVAKEQITDADTKDLTEALDEDADPTKSALSAVAALAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDVLRQAKQEFRELKAEQHRKEREATAARIRRRKEEKLKEQEQKMKEKQEKLKEDEQRNSAAVPGYGEEEREDFDTSTENKNIEQKDLDPDVVTEDEDDPGSHKRSRRGKVGQTAVKQCIKQEEMNYCIKQEPLSADAEEALRQEQQQKEKELLDKIQSAIACTNIFPLGRDRLYRRYWIFPSIPGLFIEEDYSGLTEDMLLPRPSSFHNNAQPRDPQVSIKTEESFLSESTSSLDQGPFDDSVLLPKPVHKPNRWCFYSSCAQLDQLIDALNSRGHRESALKETLLQEKSRICAQLAHFSEEKFHFSDKPQADSKPVSSRGRSSGACDISQMSAERQLELRLRDFLLDIEDRIYQGTLGAIKVTDRQVWRSALENGRYELLSEESKENGVIKTVNEDVEEMEMEQARVIVRDRLLGIKTETPSTISTSASTPQSVSNVVHYLALALFQIEQGIERRFLKAPLDGNDSGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVMWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKAVPDGDWFCPECRPKQRSRRLSSRQRPSLESDEEMEEGMEDDDDEVDDDDEEGQSEEEEYEVEQDEEDSDDDEALSPPKRGRPQVRLPIKTKGRFGPSFPSRSQRQDPGRYPSRSQQSTPKNTAKSASKNLRKTRSAPPTETRSLRVGSRSTRHSPSALQDVFVELLSPHSKRRGRKGADHTPEHSPSFTNFRVSTSRSSRQLIPLNTAESLSLQHSESKRRGRKRQSTESSPVPLNRRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVSPSTVDQVSTPLAAKKSRI
The following text describes a protein:
Function:
Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Subcellular Localization:
Cytoplasm.
Sequence:
MISSNPIGIYIHIPFCVRKCPYCDFVSFRYSKEEEERYISHLLREIDMKSKGETIDTIYLGGGTPSILSLKGLEKIFEFIQEKFKLSKGVEISMEVNPGTVDREKIKVWKELGINRISIGAQSFIEKELKILGRIHDTDDIYKTFHMLREADFKNINIDLIYSLPFQEQEDFYFSLKEAVKLNPEHISIYNLMIEEGTLFYKMYLESKIKLPDSDMEAEMFSFAMNYLKDNGFIHYEISNFSKNENYKCKHNLKYWNQEKYYGFGVSAYSYDPPVRYGNCRNLYVYYGKIKKGILPIEEREFLTGDKLAKDFLFLRLRLMEGISKKEFENRFDKRIEYFMKNYSVFLENGLIKEEGDRVALTEKGILLANEIFQDIL
The following text describes a protein:
Function:
Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.
Sequence:
MEKSQLESRVHLLEQQKEQLESSLQDALAKLKNRDAKQTVQKHIDLLHTYNEIRDIALGMIGKVAEHEKCTSVELFDRFGVNGSE