lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The terminase small subunit binds to the packaging initiation site and regulates the ATPase activity of the terminase large subunit. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging 'pac' sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging). Once the capsid is packaged with the DNA, the terminase complex is substituted by neck proteins.
Domain:
The N-terminus contains a helix-turn-helix (HTH) doamin that is involved in viral DNA binding.
Sequence:
MAAPKGNRFWEARSSHGRNPKFESPEALWAACCEYFEWVEANPLWEMKAFSYQGEVIQEPIAKMRAMTITGLTLFIDVTLETWRTYRLREDLSEVVTRAEQVIYDQKFSGAAADLLNANIIARDLGLKEQSQVEDVTPDKGDRDKRRSRIKELFNRGTGRDS
The following text describes a protein:
Function:
May be involved in protecting plant tissues from pathogen infection.
Subcellular Localization:
Secreted.
Sequence:
MMKTLGAVLSLSLTLLSFGGAHAATMSFKNNCPYTVWPASFGNPQLSTTGFELASQASFQLDTPVPWSGRFWARTRCSTDASGKFVCETADCDSGQLMCNGKTGIPPATLAEFTIAAGGGQDFYDVSLVDGFNLPMSVTPQGGTGTCKMGSCAANVNLVCPSELQKIGSDGSVVACLSACVKFGEPQYCCTPPQETKEKCPPTNYSQIFHEQCPDAYSYAFDDNKGLFTCSGGPNYLITFCP
The following text describes a protein:
Function:
This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. It is required for the switch from immediate-early to early mode of gene expression (By similarity).
Subcellular Localization:
Host nucleus.
Sequence:
MFWHQPRQQQLRQLQRAASGAGKHQRRSPPQTLGDDGDAAAQVPPSPTGALLAFLNQHASEEGGAAAASADGRVSVSPGFCSSILPEHSQDLFAFSDPTSASPQPVPMDASLSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWRPVHGPSWWLSSSSPSGSSRGSVTSPQYSGEETSDAASGAPTPPPQSSGSSYVYGQALADLMAMIQEIPAPPRSVPDCRRGEPVSEDGMADRCETDASCYTTDEPMEAEPSEPAGGVSWLGERADRMRADQSPRGLGAEPHVAEAGRPSSCVGEERADVVAIAAVEERKEAARRSPDAERNDDEEEYESLPCAQEFFTSQELAEINARAIAESDEAEDEDAGSPAARSQSSPFPSLGPAVFVLAPTSAKSSRGMRKKAIAVSRVVPDNDGEPDPCADGPGRDHVSSAQSAGANGALETETSVPRSATAPAGAVAACAQNTKRGYWRGAAAGHAEEETDSDDEDVLVVDVSACAEPFESFAQRQQPRQQQHAPRNKPARQRLRAGAIVAAASGNTLTVPSEPPHPSLAPLWKMLNLWLSEEWPAQGGGQDEGEAAVSASLLAPGSLPELPDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYYGKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKICLPPDGGDDRDGGGKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAPLVFPGASPPVGADDSPWPTSPIRECAAALREGFRALNDIRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVGASVVHDGRVGLPAFFLRGVTERREDLFSAARRCPRALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLSVTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTPASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDGLAALRPLPEGYVPRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRLAEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAALAGRACVPGSACDPETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESMLRRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPSLGPSASPHRGVGGKHRDKRPCLAEGTPSAPSCRDAARATAPLSGDPVAHRLLMHRPAKPLVGEEACAALLGGKAGRRGQDVPLPFLTAATLRKVARVARELDPGWGHGDLGCESAVVFPPAAPPGPELADRHADRRRSTKGPQRPGGKRPRSSSSSSSASHDRSPSSSSRRRDGRPSSRRRPSRRMSARPPSRPPAAVILRASWRYAEEVAREMLDAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSLPRAPTPRSGEALAAPRRSGAKDPRQGQYCPSARRSEAPHSPSPRDVALRLLERQQELNRQLLLELRRGSCEISPSPRRRDAEGRRFGCRQDDDDGYDYEGGRESPERVLGRRQSRRDSVPVRRRSGAANCGGRWMISAGRSSSSSSSSSSSSSSSPSSRPSRSATPSLSPSPSPPRRAPVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSPDGTAPGDAPLNLEDGPGRGRPIWTPSSATTLPSRSGPEDSVDETETEDSAPPARLAPSPLETSRAEDSEDSEYPEYSNPRLGKSPPALKSREARRPSSKQPRRPSSGKNGHTDVSAASAFFLGRPAPGSCGRRPLGARVRGGTER
The following text describes a protein:
Function:
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbD) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.
Miscellaneous:
MISCELLANEOUS: 2 of the reaction center chlorophylls (ChlD1 and ChlD2) are entirely coordinated by water.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MTIALGKFTKDESDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSAPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit pol1, an accessory subunit spb70/pol12 and two primase subunits, the catalytic subunit spp1/pri1 and the regulatory subunit spp2/pri2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Present both in soluble and chromatin-bound form.
Sequence:
MEFPIDDEELLDERNKLLQICNMDEQTMFYKWESWCLQRGNTPKLDLDTFKAFAKDMKFQMERQVKATLKQNPERKSIKQIPGMNIDSILGLPVKTTASGDSLMQESKPSTETFELNSSDAGRVLEVLNKELKIVTSKPSAPSKLVIVANFDLKAFNYRIMYQKLYDSSEVLDDRIELFSALTCRKYNISDEDLANPSELTQEPVVVVGRIVVESTNLGGRLNQNSILLESSRRLGAGVRVRLKVDDLPSYSIFPGQIVSVKGSNPSGNMFIAKEILPIPPLPFPSSSKQEHATFVANTNNQPISIYIASGPWSLRDDLSFSPLKSMISYVNKNPVDLVILCGPFLDINHILIRTGNITGTSATSLEELFKERVTPILSQLTCPCILIPHINDAASDHPAWPQDAFNRVALGLPSNFKCFPNPCMFSINDVVFGVSTNDILLHTSREELFRLPSHGNLFARLVSHVLHQRHFYPLFPGGSLEKCNPSNLDIAHLKLGEFLNTMPDILILPSDLRYFVKNVENVVSLNPGKATKGINLGTFAKLTIAPLELGDNGSSNHYSHRVWLRTKAEILKL
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers both EA2 and the diglycosylated Muc5AC-3/13 as substrates, albeit at very low levels fro Muc5AC-3/13.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Domain:
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Sequence:
MCLDIWRHKKKVLPLLLLMAIGSIIYYLYTLKLEGERDESATSTTSRLERDIRDLQAVFESEVIPDLGALGRPARGNWTEEQLEAIAKSQRETGYNAWLSKRISPERSLYDMRHRSCKKLKYPMEKLPSVSVVITYHNEEASVLLRTLSSLRSRTPIQLLREVILVDDGSTQADEKLNDFIKIKFLNMVQHRRITTQVGLMHARVVGAELALADVLVFLDSHVEVTKGWLEPLIAPILEDNRTCTTPIIDTIDFDNFAYRRGKPSRGFFNWEFNYIQLPLLKEEAVAMPAPHKNPIMNGGLFAIGREWFSELGGYDKGLKIWGAEQFELSLKLWLCGGQILEVPCSRVGHLFRDGNFQIRYTNKDKNSEKKLISRNYRRVAEIWLDEYKDKLFANMPHLTVIPVGNLAEQRDLKNRLHCKPFKWFLDNLATDFLNLYPILDPAEYASGVLQSISSPKLCLDRKDPSHGQPKLAPCSSDHVFPSPEQYWSLTNHRELRSGFYCLEVRNHGVNVHIYQCHGQSGNQFWSFDSKTHQVISGQQQNFRHCLEAQPELNAVTSSVCDPKNHKQQWKFGYLNSQRLQHFWDNVKTQ
The following text describes a protein:
Function:
This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription.
Subcellular Localization:
Cytoplasm.
Sequence:
MTLFFSHCLIPKRLVYGECKVPLKSEGWRGFLTLCQKAETVDQLDELFGLLFTLEEKEQLALRVELVRALLRGEKPQREIAHDLNISIAKITRGSNALKTTSDKIKSFIKKYLP
The following text describes a protein:
Function:
Displays esterase activity toward palmitoyl-CoA and pNP-butyrate.
Sequence:
MIEIESRELADIPVLHAYPVGQKDTPLPCVIFYHGFTSSSLVYSYFAVALAQAGLRVIMPDAPDHGSRFSGDAARRLNQFWQILLQSMQEFTTLRAAIAEENWLLDDRLAVGGASMGAMTALGITARHPTVRCTASMMGSGYFTSLARSLFPPLIPETAAQQNEFNNIVAPLAEWEATNHLEQLSDRPLLLWHGLDDDVVPADESLRLQQALSETGRDKLLTCSWQPGVRHRITPEALDAAVTFFRQHL
The following text describes a protein:
Function:
Essential regulatory subunit of the mitochondrial calcium uniporter (mcu-1) channel, a protein that mediates calcium uptake into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MTSKTVFQNAFKTFLDFAINSLPSTQGGLNITATAPGGVGQRPFTNKAGVLKLIFVSASSLYIGGLIAHKGASYLEENEIFVPTDEDDDD
The following text describes a protein:
Function:
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus.
Sequence:
MQASSSRSAHLSEWQKHHFAVTSGTCTPGQKADAFRAQVLRIQYAWANAEISQVCAAKLFKKYAEKYSAVIDSDNVETGLNNYAEDILTLARSQQTDSDQWRSGLSINNVFQMRSVQEMMEAGRKSRDSLLAPAAASVVIHRETVVSDLPKCSFWGTSEESDPLTNSACGTGGNQDIPEGSPMTCPRNAQPPLVANPTTTCPVLAPFGASGTVKAHAKPLFGNVRKESTNAPKANTGLNVFSSDLSCFPSGCENPRERKALFSYSTTDALSTPVLHKAASKTEDNGQREEGSLPAFRTAREQLWVDQQKKAQQPQRAPGPLYGGVKKSLGAGRSRGIFGKFVPPVPKQDGGDEGGGMQCKTSGAGPAEPARPVDERLKSLEPKMIELIMNEIMDHGPPVHWEDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGAATSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVVNLMSREQCCLSEEEIDLVVGRSDGFSGADMTQLCREASLGPIRSLQAADIATITPDQVRPIAFSDFENAFRTVRPSVSPEDLQLYENWNRTFGCGK
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Promotes organ development by modulating cell division rate. May regulate mechanisms producing carbon assimilates or importing sucrose. Involved in the repression of the abscisic acid (ABA) signaling pathway during seed germination and seedling growth. Required for auxin distribution or signaling. Involved in oxidative stress signaling. Prevents anthocyanin accumulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAPNVRSSSSFSRNISVVSSPQIPGLKSGPNGTAFISSGIRDLDRILGGGYPLGSLVMVMEDPEAPHHMDLLRTYMSQGLVNNQPLLYASPSKDPKGFLGTLPHPASSKEDKPTAPDPDQGESLRIAWQYRKYLENQKNAIDDYSNDFDMRKPLERQFLSGRPIDCVSLLDSSDLSIAQDHCATFLSKFPRNSSNIASIGRIAIQSFCSPLCEYSEKESDMLSFIRLLKSMLMVSNAVAIVTFPPSLLSPSSSKRLQHMADTLLSIKAIPDGDKELEKLLTGYKDINGFLNIHKVARINTQVPVILEAKTFSMSLKKRRFLALECLNQAPVDGSSGTSYGTSGSCSSKSGALDF
The following text describes a protein:
Function:
May play a role in reduction of the SoxR iron-sulfur cluster. May work together with the RsxABCDGE complex.
Miscellaneous:
MISCELLANEOUS: Part of the rseD-rpoE-rseA-rseB-rseC operon.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIKEWATVVSWQNGQALVSCDVKASCSSCASRAGCGSRVLNKLGPQTTHTIVVPCDEPLVPGQKVELGIAEGSLLSSALLVYMSPLVGLFLIASLFQLLFASDVAALCGAILGGIGGFLIARGYSRKFAARAEWQPIILSVALPPGLVRFETSSEDASQ
The following text describes a protein:
Function:
May contribute to UTP accumulation needed for blast transformation and proliferation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEDRRQAFTADMSTLPGYTGARISGCWALRTDGGGSGEDSLDRLLPPVSTSRRKSSNLGKTEPPLLRTGTRTIYTAGRPPWYNEHGAQFKEAFVIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKVLSAEEQALAASNDYNFDHPGAFDFELLVTTLRKLKQGKSVKIPVYDFTTHGRQKEWKNVYGASVIIFEGILSFADKELLQLMDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQYNKFVKPAFEQYIEPTMRLSDIVVPRGGGNMVAIDLIVQHVHSQLEEREISVRALLATAHQSQPLPQTLSVLESTPQVRGLHTIIRNKDTSRDEFIFYSKRLMRLLIEHALSFLPAKPCTIQTPQGQEYKGCRFGGKGITGVSILRAGETMEPALRAVCKDVRIGKILIQTNLDSGEPELHYLRLPRDISEDHVILMDSTVSTGAAAMMAVRVLLDHDVQEEQIVLVSLLMAELGVHSIAYAFPRVKIITTAVDKSLDDLLHVIPGIGDFGDRYFGTDGSSSWSEEDQQEPLSCSSEV
The following text describes a protein:
Function:
Probable member of the two-component regulatory system YkoH/YkoG. Potentially phosphorylates YkoG.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLADETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLSFHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAASAAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTFNEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIHSEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKESLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIPHLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQNGGGR
The following text describes a protein:
Function:
May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSTFTRLIAATSSTFPRQCLTGGVLFATGDTIAQQLVEKRGSRHDLARTFRLSLYGGCVFSPLASIWFGRVLERVRFSSKAANIATKVALDQAIASPAFVALFFGATTIMEGGSPDQAKNKIIHNWWPTLKTAWGLWIPVQTLNMALVPPSQRLLFVNVVSIFWNTFLSIKSAAASDHAVKPNLNDAVELVETKLDKLH
The following text describes a protein:
Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine.
Subcellular Localization:
Secreted.
Sequence:
MLVVFLCLLSVTLEATEGFKNLSGKVLQFKTATDNSYVKLYPEKPLSLSAFTLCMRVATELPLDREVILFAYYTPDVDELNVWRERDGRVSLYIQSSKDAAFFRLPPLSTLQTHLCVAWESATGLTAFWMDGRRSLHQVYRKGYSIRSGGTVVLGQDPDSYVGSFDVDQSFVGEIANLQMWDYVLSSAQIKAVYYNQDNRVKGNVFDWDTIEYDVTGNVLVATDN
The following text describes a protein:
Function:
Activation factor which mediates telomerase activity and potentiates responses to auxin through the regulation of BT2. Binds in vitro to the DNA sequence 5'-GACAGTGTTAC-3' of the BT2 promoter.
Subcellular Localization:
Nucleus.
Domain:
Contains a slightly degenerated ERF-associated amphiphilic repression (EAR) motif, which may be involved in the activity of transcriptional repression.
Sequence:
MENIKNPKNADDCSDSISKNSHQGVDDSLNQSRSYVCSFCIRGFSNAQALGGHMNIHRRDRAKLRQKLMEDNKDDVVAESDASEVVSLDLNEQQQQQGEALTCDDHDQYVDNDISPKQKLEFWVQESKLDTNDHGKVTEASIDGSSSSHHRDIEVLDLELRLGQSVVKKKTT
The following text describes a protein:
Function:
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture; (Microbial infection) Acts as a receptor for enterovirus 71.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
The following text describes a protein:
Function:
Involved in intron recognition and spliceosome assembly (Probable). Probably active at the 5' splice sites.
Miscellaneous:
MISCELLANEOUS: The splicing pattern of the pre-mRNA is regulated in a tissue-specific manner and by development, and changes in response to various types of abiotic stresses.
Subcellular Localization:
Nucleus speckle.
Sequence:
MRRYSPPYYSPPRRGYGGRGRSPPPPPPRRGYGGGGGGGGRRGSSHGSLLVRNIPLDCRPEELREPFERFGPVRDVYIPRDYYSGQPRGFAFVEFVDAYDAGEAQRSMNRRSFAGREITVVVASESRKRPEEMRVKTRTRSREPSGSRDRSHGRSRSRSISRSRSPRRPSDSRSRYRSRSYSPAPRRRGGPPRGEEDENYSRRSYSPGYEGAAAAAPDRDRNGDNEIREKPGYEAEDRRRGGRAVSRSPSGSRSRSVEVSPR
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKRSKQATLSRFFKKPKTGADAVHTEAVIGKKPTDSGSPAEQKDAKSPQQVTDEPPLEPVTVTTDVVAMDTQPDLSIGSEINSKSRPKSLASFKSGKSINTDHNPELKQKFRAKLELVRNKNDEDLPVITKKTKLNATEFQWYEIKKQHRDTLLFVQVGYKYHIYGDDAEIAHAQTRLFLSPGITNLKDIGNDGVVQQGSKYIKLAYSSFPVHRIDFYTKQLVEKGFKVGHVQQMEVAALKNVENKKGPMIRELTNTFTKGTYIESGNGGSVNDVQYSSYLVALHESKGDKPTVTLLATEVSTGDVIWDSFNDDYVKSELEIRLLTLAPCEILNCGVSSSTLKMCQKYMHRNKGRLAEMNVLEEEVEDPDAQVALFFEGKANAGTCSTVLELPAMVKTLILATSRYLTHCKLDSLFLLTNNFTRYTGSYMRLSANTVASLELFANTTDHTAKGSLFWVLNRCLTVFGSRELKKWVSRPLTDRTAILQRLSAVEAIIKSIYGAESDELTTLINKLVKLLKPIPDLSKMLMRLHYGQLNRKEVYLLLRELLFVAQEFKPGSGDKYIDTNPVLGEIFNSLGIHVSDIEKLLEEINPDAARQDEALTFFVTDPPSLVDRKKDLKKVEAELQIELLALRAELNRPKLQYSSVAGIDYLIEVANKDTKKLPLEWTKISGTKSVSRFRTPTLNSLVKRHEYCVEKLKAACDIEFNMFRSRCATHYEFFRSMVVAMSQFDCLFALAKVSGQSGWVKADYVDEGGIDLKDSRHVITEKLMTNYISNDIKIRCPTVVTGPNMGGKSSLVRQIALSVLLAHIGCYVPASKAQIPITDSILCRMGAQDNIMSGQSTFMVELCECAEILRNATSKSLVLLDEIGRGTTTTDGIAIAHSVLKHFIELEALTLFITHYPLGQLLDSEDSNKCDLVHMDITNTNPPIFTYKMKPGSATDSYGLNVAGLAGIPQAIINRAEEMGKDMKHDVMYQEGVRMLTDIKKVM
The following text describes a protein:
Function:
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Miscellaneous:
MISCELLANEOUS: This protein is encoded by an amplified gene in multidrug-resistant cells; MISCELLANEOUS: This protein has been shown to bind calcium with high affinity.
Subcellular Localization:
Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
Sequence:
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MHQSLLCFGARRLPMTTKLGHQYYKGTRTGKMGQKTRHGGFLVQWSRVRTFVPPSGDCELLPFVSRRIQATKGTYPEGANGLDGAVYFDLAHS
The following text describes a protein:
Function:
Apoptotic suppressor.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Predominantly nuclear. According to PubMed:9372964 it is cytoplasmic.
Domain:
The ring finger is important for its antiapoptotic effect.
Sequence:
MNIMDSSPLLASVMKQNAHCGELKYDFSCELYRMSTFSTFPVNVPVSERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAMEKHKQVYPSCSFVQNMLSLNNLGLSTHSAFSPLVASNLSPSLRSMTLSPSFEQVGYFSGSFSSFPRDPVTTRAAEDLSHLRSKLQNPSMSTEEARLRTSHAWPLMCLWPAEVAKAGLDDLGTADKVACVNCGVKLSNWEPKDNAMSEHRRHFPNCPFVENLMRDQPSFNVSNVTMQTHEARVKTFINWPTRIPVQPEQLADAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWIEHAKWFPRCEYLLRVKGGEFVSQVQARFPHLLWNSSCTTSDKPVDENMDPIIHFEPGESPSEDAIMMNTPVVKAALEMGFSRRLIKQTVQSKILATEENYKTVNDLVSELLTAEDEKREEEKERQFEEVASDDLSLIRKNRMALFQRLTSVLPILGSLLSAKVITELEHDVIKQTTQTPSQARELIDTVLVKGNAAASIFRNCLKDFDPVLYKDLFVEKSMKYVPTEDVSGLPMEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKECAPSLRKCPICRGTIKGTVRTFLS
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLILTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSNIPFYFISPVANSSLEFSQIFAEWLCHNKQTKVYLPEPPFPHAELIQTNKLKHYPSLHGDFSSDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADALVPMEIKPGISLATVSAVLHTKDNKHVLQPPPRPTQPTGGKKRKRASDDIPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEVLRVRLRDLVLKFLQKF
The following text describes a protein:
Function:
Sialorphin may be involved in the modulation of mineral balance between at least four systems: kidney, bone, tooth and circulation; Submandibular gland peptide T is able to directly or indirectly down-regulate cardiovascular depression induced by septic shock (endotoxin stimuli), or anaphylactic challenge (nematode antigen sensitization); Sialorphin is an endogenous inhibitor of neprilysin. Inhibits the breakdown of Met-enkephalin and substance P in isolated tissue from the dorsal zone of the rat spinal cord. Has an analgesic effect when administered to rats by intravenous injection.
Miscellaneous:
MISCELLANEOUS: SMR1 mRNA is about 1000 times more abundant in the submandibular gland of male than female.
Subcellular Localization:
Secreted. Note=Found in blood. Secreted from the salivary compartment into the blood circulation, rather than through absorption by the gastro-intestinal tract.
Sequence:
MKSLYLIFGLWILLACFQSGEGVRGPRRQHNPRRQQDPSTLPHYLGLQPDPNGGQIGVTITIPLNLQPPRVLVNLPGFITGPPLVVQGTTEYQYQWQLTAPDPTPLSNPPTQLHSTEQANTKTDAKISNTTATTQNSTDIFEGGGK