lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Prefers long-chain length polyphosphates as substrates (By similarity). Can also hydrolyze ATP and ADP substrates, but lacks GTPase activity. Cannot hydrolyze pppGpp to ppGpp.
Sequence:
MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLGQGVDATGRFAPEAIARTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTADVLGAALPGSAAEVITGAEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVASYSADIGCVRLTERCLHSDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTMTTLSALAQSMTAYDAAAIHLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGGGAIVVEELARELRERAGIDQLTVSEHDILDGIALSLAG
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDSRDTGETDQSKYKGIRRRKWGKWVSEIRVPGTRQRLWLGSFSTAEGAAVAHDVAFYCLHRPSSLDDESFNFPHLLTTSLASNISPKSIQKAASDAGMAVDAGFHGAVSGSGGCEERSSMANMEEEDKLSISVYDYLEDDLV
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Sequence:
MSLSIVSYYGSQQSKCGYCAGANCSLSHGMHAYQLDCRDYQDLIDRGWRRCGYYCYKLRNQETCCPCYTIKCNGLEFKLSKSNKRILRRINRFLRDGKRESKPEAGDGDGEADADYAIVAPEVTASEPQPQLPDKSPPVINVEQVASLATAQRKPTKQATAAAVEAPTLGSNKSSLLSSSAAAPISNKPCKKAKQMRLDRRLAKLGDSASYSTKSLTQEKTLRDFLNTDSETNKHRLKLRLIHVYDDEFRRTLPQSFALYKKYQISIHNDPPKDQDAYKEHLQATPLQNEKPWDGPEMGYGSFHQQYWLDDKLIAVGVIDILPGCVSSVYFFYDPDYSFLSLGTYGSLREIELVQSLAEKVPSLKYYYMGFYIHSCPKMRYKGKLSPSYLLCPETYEWLPLTDVIRAKLDEHKYQRLNEDPAARDVNEFLMEHLDEVKLLLGGRTRTDYKHFRQLRGTVSDDDIIIEYSKLVGKECARRMLYVK
The following text describes a protein:
Function:
Required for the specification of pole cells and germ cell formation. Mothers with reduced glc function give rise to sterile adult progeny that lack germ cells.
Subcellular Localization:
Cytoplasm. Note=Pole plasm.
Sequence:
MGQIVGSMHMNVAEVFSNRRKRKRSTDSSLGKDDPAQLDTTQPKKKKLLTTTQYIYKALFKEEKNSDVAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSDEIEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIYSKQPNLLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQRAEALKTQELLVNAGVETHAPSGDVVQWTYFTSRSEERSFLATPEGQPYVKVFQKLRTQYLTNHYMDLKIIYNDNIIPKEWLYRHIHNHWDALLRIDHGQEDCSPQQLDDEQFFENCMRCGRMLLEPGYQKWRWTGFNFGMDLILIMDSRRLNIRRHHRHEHERVLSLQTKRKFMVRTTVTSINAQRQAVFTQTSEICSLSLEKNEEVPLMVLDPKLVHPLLISINMLVVMPPNQSFKEIVPLSEEATTSLSIPISEIGANSDRPLSPSSADDSAVFIGDSEPSTPSSPAPRPRIAWSASETGAICGQLAC
The following text describes a protein:
Function:
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.
Subcellular Localization:
Nucleus. Note=Localizes to sites of DNA damage.
Sequence:
MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQRVKKHGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTRENVPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKMEVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSEDLLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTGRQIEDRVALLLSEEVELSSTPPLPASRILKEGWERAGQCPPPPERKQSFLWEGSALTGAWAMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVPPEHSELSERRSPALHGTPTAGCGSRGPSPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGTAGLDVVPGGLPLTGFVVPSQDKHPDRGGRTLLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHEEDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQWDKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSSPSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPLLQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGEVSASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNGLRVSSRRLLDFLDTHCITFTTAATRREKLQGRRRQPRGKKKVERN
The following text describes a protein:
Function:
A redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigR, and a key sensor of disulfide stress. Holds SigR, its cognate ECF sigma factor, in an inactive form, inhibiting its sigma activity under reducing but not oxidizing conditions; oxidation and reduction of the anti-sigma factor is reversible. Mycothiol (MSH) is competent for reduction of RsrA, allowing it to bind to SigR. In conjunction with its cognate sigma factor SigR may sense the intracellular level of reduced MSH. Probably releases SigR during oxidative stress.
Miscellaneous:
MISCELLANEOUS: A quadruple Cys-3-Ser, Cys-31-Ser, Cys-61-Ala, Cys-62-Ala mutant has anti-sigma factor activity and is induced by diamide.
Sequence:
MSCGEPHETDCSEILDHLYEFLDKEMPDSDCVKFEHHFEECSPCLEKYGLEQAVKKLVKRCCGQDDVPGDLRAKVMGRLDLIRSGQSVPEHDVAAAPSSSAPQES
The following text describes a protein:
Function:
Extracellular metalloprotease that contributes to pathogenicity.
Subcellular Localization:
Secreted.
Sequence:
MPFDSSKLFQTYQSHRDIKQYLDTLLQQHSSKIEVFSRAESYEGREILTVRICHDVREQKRPNRWCILIDAGIHAREWITVSVALFIVRQLIEKDEISAKSFRSFEWIILPLLNPDGYEYSREHNKMWRKTRRPLGPRHRRSCVGVDCNRNFNVAWTIGSARFCSLLYRGERPFSERETKNVRDLFRKLRPACKFYLSLHSYAKAILYPRAYTRTLPRNWQMQHTIAEAGVEAMKKATGVRYRCGSASTVLNRPVGGSSIDYAHDIEKVPVALVMEVASKGFHPPEANIERICEESWIGIGAMVNCLASSFRSVLKGSGTLHLR
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
Sequence:
MKIFFIDNFDSFSYNLVYELECLGYEVAVYQNDIDPSYLMDLMNEESKTPLLFISPGPGNPNSSGNLLKIIAMAKKKFPILGICLGLQALAQSYGAKIIRSKEIVHGKATAIALKKHAVFKGLGESMVVGRYHSLMASGLPKNLEVIAEHDNIPMAIVNEEDKILAYQFHPESIMTLQGRALLEQSVGFLEGLL
The following text describes a protein:
Function:
Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The disordered region interacts with HSPA1 and HSPA8.
Sequence:
MSLQKTPPTRVFVELVPWADRSRENNLASGRETLPGLRHPLSSTQAQTATREVQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGVQAENITVTKDFRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPQFYHTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTLGKPLLIKEEETKEWEGQIDDHQSSRLSSSLTVQQKIKSATIHAASKVFITFEVKGKEKRKKHL
The following text describes a protein:
Function:
Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAKYDYNPKYGLENYSIFLPFETSFDAFRSTTWMQNHWYQSITASVVYVAVIFTGKKIMEKYKPFQLDTPLFVWNSFLAIFSILGFLRMTPEFVWSWSAEGNSFKYSICHSSYAQGVTGFWTEQFAMSKLFELIDTIFIVLRKRPLIFLHWYHHVTVMIYTWHAYKDHTASGRWFIWMNYGVHALMYSYYALRSLKFRLPKQMAMVVTTLQLAQMVMGVIIGVTVYRIKSSGEYCQQTWDNLGLCFGVYFTYFLLFANFFYHAYVKKNNRYTEVKKDKKEKEEPVDFEILEPKEDINANIAEPSITTRSAAARRKVQKAD
The following text describes a protein:
Function:
Putatively gated water-specific channel, requiring a cysteine residue within the channel. Impermeable to water, glycerol and urea when expressed in Xenopus oocytes. Not regulated by pH; channels remain impermeable to water at pH 7.4 and 5.2.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Expressed in lamellipodia-like protrusions of the plasma membrane and intracellular vacuolar structures.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MSLKRSDDYQDLEEGIAMEDGGNIKDEEEKPLDPIEEQNKKRWVLIRAVLGELLCTFLFVYVLCATSANFIRLGSPPNPVVGGLSTGFAAVALIYSFADVSGAHFNPAVTFATCVTRKTSITKGLMYVGAQLVGSVLASLILLATFPGNFPGDKNAASAVAIAPSTDANIGNAFLTELVLTFILVYVIFAVAFDTVDNSVKTKVVGKSSSNNLTIYTTSGQTKAGFAPIAIGFTLGFLCFLGGSVSGGAFNPARVFGTALVGNNWTRHWMYWIADFLGAGLAGFAQKFFSSTHK
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRSECYNGSGASTSSPKRRVNVVGNGRSHHHHQRQHHAAGGANTHRDTTTHDRGTDSPPTLTELPPSSGSFLHISITKLAIGSRLFVIVLQLVANLLLPDHEAGVFVAPSDKNASERPLDALVRLVLGGLNRWDGQYFLHIAEHGYTYENALAFFPLFPFILKIVCSSLSSYEVITFVSYRELSLLLAVLLNVVCFTGAAKALYRLSKHVLGNQKKAEIAVLLFCFNPASIFFTAPYTESLYAWLSFVVMYQCIEDVTSIFLTIPLSLSILCRSNGMFNIGFVLYFAVRRIVAQYNVHNVICICSRLFSMLIIVLFHYGIAQVYNYYLFCFVQKFNFPDHVREYAAEHGLVLAGNKTDDSSPWCTNLVPLSYSYVQSHYWNVGFLRYYELKQLPNFLLALPVVYLVLSNSYQYLCEHWEYALRLGLFRLTKKQHKVMRPYDRFALVFVVHALVLTLFSLVFVHVQVTTRLLCSASPVLYWYTAEYFTGERAFIKRQVIRKLSKQVKDGEENSCTHVLNHIELSDLLDFRWMNGRQQTILVYFLGYTVVGTVLFSNFYPWT
The following text describes a protein:
Function:
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
Subcellular Localization:
Lysosome membrane.
Sequence:
MSAKEVDFERESHLHAVMCFLTGQSGEKIVSIYPHRKPATKAPSKDPQPSSSNPGQCVKPVLTSVKDPSYGFGRVDTEFDMSLGMLAYVFKTQEIACNDGFDMKINNQRFVAYPKTWKARGESTNYQISIVFALKNGCEQHTASAYQTLSNKIAVSLVMLQNYFGFLEREDKWADNAEEPNKDHPLEEFAKTSFIVQPLAEMFEEVRNRGNIHKYLINFVELGFCDEAHALTKLNVVPKGRQEIDEIVRKMKPYHGILLLEDVWPTPDANPIVAKLLSHCSPDRSILDMSTASGIPIFEVFMIIRHLLQWTRAILIYPLCNTNIYTSATSPQPLDKMAEKFTAQFGNTIHLAAGLAHFNPPKTLDTFIRKNLPLHEQGVRAKLVVALLRHQMLMQLHQFYYILKPYSIAILPEPKEPCPAEFTKIIEESTLPNDVKGVVADICAEMLETTSYASVKRTLSLFVKVAPMMDGNHHLEEIKYKNNLDRTEIEGVFVSFKLVIATFRRPDFVAE
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). Within the MRN complex, mre-11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (By similarity). Mre-11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (By similarity). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination (By similarity). Required for meiotic crossing over and chiasma formation. Pachytene morphology and homolog pairing are normal. Vital in long term for maintenance of reproductive capacity of subsequent generations.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to DNA double-strand breaks (DSBs).
Sequence:
MCGSDDSFDDFVPDSQEPASSRTRNQDHLDDDEVPCSQRPDAANDTMVEDLDEGDEPAHDESEDIIKILVATDIHCGYGENKANIHMDAVNTFEEVLQIATEQKVDMILLGGDLFHENNPSREVQHRVTQLLRQYCLNGNPIALEFLSDASVNFNQSVFGHVNYYDQNLNVGLPIFTIHGNHDDLSGKGLTALDLLHESGLVNLFGKHSNIQEFIVSPILLRKGETRLALYGIGSQRDDRLVRAFKNNSISFLRPNAGAEDWFNLFVLHQNRPRRAMHRSTGNFLPESLIPQFFDLLIWGHEHECKPDPQYVASSEAVGDGFYILQPGSTVATSLTPEEALQKNAFLIKIKGRKFASKPIPLQTVRPMVCDELLLDKIPPGSRPILKTDRPKHTDGRYIDEIAIEAKINEMITTAKAKRRPRQPELPLIRLKVIYDGDWLNITPANAKRIGLRYENVVANAVDMVFIKKNNKPKEGKLQTENEKNITEMADEMGQVSATNLQTIINDYFINQPLVDQMTVLKPIGIGRALEQYSAIEEGGLATSANRNFDSCLMHQIDVVRKTLKKMPLPPINDPSDLDKFRDLITKDLYDMKKADSERFKNPVADVEMEEDEDDPQYYMPPQSTSRTNYASGSEDEVANSDEEMGSSISRHSKQPTTRGRGRGARGAGASRETTRGRSNKVVSTRQIDSDGFEIINDSPSPPPASRSTRGKARGKSAPSKKRDLSFF
The following text describes a protein:
Function:
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAPAGPWLVLCEEKIREKSGLAPHHDLAELRSLSIPGTYQEKITHLGNSLMHLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNSISSLAEVLWLHSLTELTDVDFRLNPVVKNESDYRLFVVYMLPKLRQLDDRPVRDSERKASRLQFASEESLNSKQSFPAVFTAGRLCHSRAMCADPSAKKCLVMDADDEAVLNLIAECEWDLSNPPGSTSSSLREQETDLHSSQDSGHLLSPHSMQHQCGDSIKKGHERKKGSSRGCGPEKRLQHQYCGELPPQCGPHAHFTPHPDSADIEDPAVSQKSSLSTQKVVNPLPVPEKYRKRRMPGGRFQAPANQEFLSHLEKPAMPSSPEETLSRHSASEGRSERTFSHSEVSEPEEERPHSRSGSGEVAPRLYSAVPPGKKAALEVMLLEALLDLVDRYWSGCKSLHGNEVFQAQARHILSSVQEFTTTQDSSTLVSEEISYLTLENKSLQKHLAEQQQQYRVKINEVASELSNTQKEMDDLRQHLDKSLEENSSLKALLFSMKKEAKNADTAATLNVQITGLQTSVKRLSDEIVELKQHLTHYDKIQELTQMLQESHSSTPFLPFRLAHPLLIHLANRQCSRTRSCGGIRRCTRTAMGAGS
The following text describes a protein:
Function:
Plays a role in the nuclear pore complex (NPC) assembly and maintenance, but with limited role in NPC permeability. Required for specific nuclear import pathways such as Mad import.
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MDGECLANEQMCVGRQITNATHASTAVIEDMWTPYKHLYNTFQTAVSNRSGFTSDLEQCLKKYKHNFSNLLRNPPRSEKSRNLLRNALNEGVPMQGHSRKTKMSQDLADEAVILSDMFDLDEGFAVELLCTAQRQQKHHPGLSRGLVAVLLYYDGRKAISCTLRDMFQVVSGVSWNTELPKEITGLVTNYAESLVDGSGILGRLLQLLEEMDVDKECAMLTTNRAFGSKKHQNQVLGLYEDIQQALAMALFNWSAQRGLPRHIAIRLMHQLANRKNHDAGGNMDDVTLIMLMALLYAYDTSMLLVTEEPNEHTTRLPIFSDREFAECFLEELYAQSSWQAPRLNAIIAYSFGLTLASLRHAPLQLQATAISIINRDEMLIDEALGAQVFVFFHSLLLEKDLVYSTQFFYRRVHLLITDFIDFMNSKVSELRGRADESSHTIISFLNEGLEPPPNLDSNFELLMLCVAKMHGDPRVTIRLCNEYWGPGDPNGSTAFKNTSRSVSLFKFISLASDLLPQTLFKAYLKMISGLTRTDFSARCAFNMLRVPQMATGGKYAVSWDHFFTTLGNYYTSMRNDFNTNIGMSGETIYRTRSTPKAITQREAEHLVAVMGIIQAVAEHDEVSRIMICDHPNWQTPQVLLGLVACATPLFLKAEILHTLAALAKSKETARVIWFHLEASQIIPTVPVSRSYAQCSLLEEMEQIESRSEQYNLTRGILQLLYTLMTTNLPKSLGAGQRTPAYEGYLKSMINSVLLKFYNRAYKVPSEKWQVGAQCLKLLYYLLATYRPSAMDFLETVDEPPYPGFHVMMQLQLKSEMLQLLLCIVEEVRERLDNYNRFQGKKLLEECSLYALLILEAALAKQNAFFEAHSAANCPILLSGLNRMLLDLNPRSRKPDHVLNIIKYVTYNSWLPRHALAAIKILASVTQLPNVSTQILSMYGQGSNEKLEIRQGFVECLEMEVCVGKHDDDLLDQLALNNHVPYLGFGDDLDNEREMSGEREYSTIESQLELQAGDGALESKPASIELQLKEAIIKLFEMNLSQQLPNFVYFLLGVDVLREFMANGRQHLAIEMQSSCVNSVVLLLEKYMDKQRHSDKYCEHTARIVERIYHLFHGLCANRRTAETILRYFRLTCSDFLLRHLRSLPFRQHREDHVLHAMGHLLNCVSIDVKLAAKHGQMTRFNQMCDILLIGNGMERSSHGLSMELGHSLISQPSSSFLAMDVLPAGGSISAVAHGAGSASLGAPNTGVKSLKPSLLQETSQGLHVTRLLDILVLEAGTLSQPQLEFFDGHLITQLLRDCEASAEAGANSRANLINVRKLYYILTDELYMVQSIIASGQRKAISTEIMLLLNHAVNINRVRTQRCATLAFMAAWGQLVQVLFSNMPDAVLPATQRRQHIIDIVEKVLIKVQPIQPIIEISVQVSETVLLLLANLRYCCYQAEDQSPEDLAAEDSLSNGNGNAIGNDSQVNALCLGQRAIGTGSDGGSGGGRDIGSGGNSSNLRFILKNLVQWIMISEVKSQKLRINLYSSLLNCLRIAKRLRTDEHLEYQETLISRQESARTYNKEQRRDDRLRLKAMAAEVIGTFGEKLIDTICHDAVTGHDVCRMLALACLDMISELQAVSTLCDFVASRGYLKHILESLDQSSTALCGILQPVPDHLRPLYVYESRMAFLTRMANSNVGARLLLTEQALGVLSNMKVYDQQPDLKSSELNRNEPQTFLPSIDDRFRSILLPALSLCDAIVNSLGPRNNSAAVQVLNFLFAHIDMVEAMLRSATPYMDLGHLQQVAVISNLFARASTHELTALEDSVQLDLRNRLGRVQQLMIVVFGRFCVSEPTIRRMLQQDEEQQTNPTDDSKRLRVKYFLDIAANVSLYCRNVVTSHSKDSMTSKYLLTTVINDVTLLTGKMSSKKLTTIMHTILNQLKGSIGYYLSQKSIADNLLQQRASLPNISFGPNGKQSYIELSQRYNEKRSELRQAVFIAEQNLYLLWIHLDFYLRNTIDYANENRNAINESNMDDDNDMSVLNASQEEIVQLKQLLISTFNETFCTQLINASEDYSIKCKGFNGSLLRRIKALVQFAPITANDVNSSFDS
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATERGSKAVATQPRRKSAAPVDDEDARALAQYTEKATQQYGRGEKIKSKSVKDRKLRSNLRTLEAKNKQAAIEAKNVEILLENNAGLIEPENELERTYQVRQDDIKQAVGVETAKKGFELRLDGLGPYDVCEYSRNGRDLLIASRKGHVATFDWRDGKPGCELQLNETVRDARWLHVSNQKNFAVAQKKCVYIYSGDGVELHQLKNHSEATHLEYLPYHFLLASVSTAGILRYTDVSTGQSLAQLYTKLGPPTAFAQNPHNAILHVGHQKGLVTLWSPNSAAPLVKLLPHHGPVRSMAVDKSGTYMVSTSQDRRMSVWDIRMFREIHTHHLRLPGQTISISDRNLTSVGYGTQLSIFKSDIFTRAADASSTQPYMNWGGDGLSISRVRYCPFEDVLGVAHERGFSSIIVPGAGEPNPDSMEQGLNPYETSKQRRETEVHALLEKLQPEMIALDPNFVGNLDLASEEQRKREKDLDRKPEDKIAKLKQRGRGRNSALRRFLRKSGSKNVIDEEKERAREVVEQRKKRNEEKRERLKKEYGPALERFARKGNQT
The following text describes a protein:
Function:
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene (E)-nerolidol.
Domain:
Contains several highly conserved motifs that are important for catalytic activity including the aspartate-rich 'DDxx(x)D/E' motif and the 'NDxxSxxxD/E' motif, both of which are involved in complexing metal ions to coordinate the binding of the isoprenyl diphosphate substrate in the active site.
Sequence:
MEEKIKFYFEIIDFQNQKFKIQEFTSKLIGLKEESFTTFKPIVYEKYLNWTQSIEESILKTNGTINKSIFEEIFSYCGYIGEFLEYEPFIVFLKFTTFGIILDDYIFEKINSLNMKLNEKEKLINSLIYYNNKNENKIGFEFWEIINEFQNFTHKESFQRIINANSLWIKSSIDSRNISNSPINSRCSFNEYFEKRSSDASGDFILTISMIGIMDNYIENSIIESKEFQTINYHAKSFFLLINDLYSFNREINENDLLNYIKILAIQLNSIQLSIDKTIELIIDHYLKFLSSIETILKLYQNDQSTYQLLKQVFQNSNKILSGIYFAHKKSKRYN
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSATPPQLKEIVGWVFEHEHGDWRCEDCSVFTKLISFQRSWLGALYDSATVDPCSYNRLAEKDVQHPAIAESTMSRNRDYSQPGSNGGYTNGYGNGGYGDDGGGRPSGERRQRPGGYGGMGAPPDDDRRRPSNDRQRRPPGYGGMGAPQDDYGRRPSGESQRERRPGGYGGFTRREDEYARPQSGGRDRRPGGYGGLQQQEEDGPEVTRPTSLERSRANRRSGERQTGSRGANNYGSGSQRIEDVLQYIRQNWDFMTQDQCVPIEVALKLMDSSSLGLASQYGQFKTTHRELQQALKAIVNAKPELKEFATASQNYDGMLQMLNAIEELQLVPEQLEARISEKRFLTAVDILQKALLMIRKTEMEKIGALNDLRTYLSNQEVSLTDILIEELHSHLYLKSPYCEDRWKEYAQNQMKGGISERTQTDARGRLLYYFLDGLDLSEPMTDDSTHNPETDTFQYIRLIVESLNKMNRLEVAVNTIEQRLPVELFKVVDKSNNEVAQRHPSILRAHASKKGGKAKTGIESDEVRSMLLNDLLWTLYARFEAIAESHRAVHDVVAGIVRREGLRDSSSAALTRGFKELWKLYQSEIRSLLHDYLATDGDALYRTGQGQTSAGSVFSRAPRDKTKRMFKLSDMNTKSPDIAQEREDLEFILKSSVPGLVSDSKKSENRVAETSTNLDGSATGHKLLVEPSVFNMGILLPPSLDFLNRLKEVVPPNSDIVMSTLTSFLDDFLVNVFQPQLDETLAEMSSQTFIELDSFSEDPHWEQHAKKPIFKCNGWYKALVTRSQPATSGRRLKAPAAWSESEEMERLVSQILQSDPSDSENFNQLVENEISLLLQVVSEEPLDQADMLQDKKSVINLCLLYTSMKWLATKAAQLRHISDRATNSGGGESSKDRHTQRWTLLTSSEPRAEGTHVYLPLNRETVSEFDQVVSSYQSLSTRILRTLHLTIRSTILHALSTSLQPNLFIDTPLNDPSPIILALNSTLVNFDTEVSRYSPQATYTRMTHGLANLMDTYLLSLCTSRIARMNTNGCAHMQLNILVLQQNLKNVEEGAELPNAALFFDLFTAGPDAIVARAKQHGKDFGVPGGMLNESSVKKLLEMTYEERLTGDNRESSVSAKRQLDAQLLEISEFMY
The following text describes a protein:
Function:
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEYMTESTDRSPGLILCCECGIAVSPNPANICVACLQSKVGISQGIPKQVSLLFYKQCQRYFQPPGTWIRCALESRELLALCSNKERLVNAGFVWTEPHSKRFKVKTPERGDEWLFVVDYAVQSQICGDCHRVEAKGFWRAVIQVRQKTLHKKAFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKPHAQKMVEFIQYTVTCRYNASQRLISQDVHSNTYNYKSTFSVEIVPICQDNVVCLSPKLTQSLGNMNQICVCIRITSAIHLIDPNTLQVADIDGSTFWSHSFSSLCHPKQLEEFIVMKCSIVQNIKHGADAGMISKKHTLREVWVQKTSEMNTDKQYFCHTHLGHLLNPGELVLGFDLASCNLNDEHGNKMNSEFQINWKLKELNMDTDDERQYQDFLEDLEEDEAIRKNVNIYRESTIPVESDDDEGAPGISLAEMPEDFHISHDATVWVVAHACNPSTLGGQGGRTV
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Subcellular Localization:
Nucleus.
Sequence:
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPISHRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTVTEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPSQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA