lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MYYAVSQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPISSSSSTSSSSTASLLPKPAREKPEAPLAEPRGPAPESGGARADAKEEQQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGDGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPPCGQFALPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Involved in defense responses. May act as positive regulator of salicylic acid (SA)-mediated signaling and negative regulator of jasmonic acid (JA)-mediated signaling.
Subcellular Localization:
Nucleus.
Sequence:
MNISQNPSPNFTYFSDENFINPFMDNNDFSNLMFFDIDEGGNNGLIEEEISSPTSIVSSETFTGESGGSGSATTLSKKESTNRGSKESDQTKETGHRVAFRTRSKIDVMDDGFKWRKYGKKSVKNNINKRNYYKCSSEGCSVKKRVERDGDDAAYVITTYEGVHNHESLSNVYYNEMVLSYDHDNWNQHSLLRS
The following text describes a protein:
Function:
Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (By similarity). Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function. May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPKPPKSPKGQKKGKKNMKQQLLVPEEEEPMNMESMGHPEIYPLVLTTKTQEIFNCRVDEDMTDEQTYKLIKKEDILADLQNRAAVSDFHPVKKIVREYPGEELLLVYDKDFKYGLNFYLIGTEDGKENFLKPPEVPEEQEEPKEHVQEDVYVYNPPVSKPWVSLGSEKEIEEESVQESGKRVTYMISRKRSEFGAPVTFSDQNASSVKDAYIECTSYPEKNYTLSQVEKDVGLQVIAEVKDTSTQTKWAFPKNATTQYYPREFSEEEKSLIGKSKSLVDFFNNVSTSVEVALQQNEIMNTFIDDWKNLAEEESTFGDKTDTHLKEYQSFTDLHNTMEKMITCVSWHPTIFGLIVVSVAVRLSYEERVQNSGRLLLQPSLLLFWSFSDPIHPQLMLESPDDIFCFEFCPSDPNIIAGGCINGQIVLWDITAHADRIENIKTGGHRSKKTSLKPMFLLEPDSNKESMYIRHCAVSSIENGHRKVITDIHWLPDSFEINRMGSVFENRSGINCQLVTCSADCTICFWDIRPQKPAVTAAAAASAATTATNNANSQQSPVEKKKEENIDIPFDVPSTFLHLDLSWKPLSRLKLSKGDTSLDHCPTKLSLGEDPFLCKIQGTSSIHIILRDKMLSQIKMVKTSEINPYQNLEAGIANILKPIEDFCTKFFVGTEEGEVIYTDWKMERDSDTGRLMAKKPVSLYTVHDGAVHTIQRSPFFNDIVLTVGGWNVAIWKEEVMTGPLLQTCCGPKRYTAGHWSLTRPGVFYIGREDGNVDIWDLLEKTHEPAQSQNICITMITYIKPWTFSSKQQFIAVADYYGTLHILEIPWTLSHPSLNEVSSVNYYFEREVRHLEYVQQRKEIREQEKIDMALELVKKKAKIYQKTKEQMEAELKLEYESYLDLEKSVLFALGLSKVSEKKSYLDSH
The following text describes a protein:
Function:
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
Subcellular Localization:
Cell inner membrane.
Sequence:
MTTFWSLWIIVITVGTLLGCAILLVWCLKDKMGVEEGVDMGHEYDGIRELNNPLPKWWTYLFIGTFIFAAIYLTLYPGLGSFKGILGWQSSDQTVRSLEESRASIAAAQQNKQLVQYSKELDDAEAYYGEAFKRLAYQDGTTNLREIPDIAADSDALKVGQRLFLQNCSQCHGSDARGQKGFPNLTDDAWLYGGEPQAIVTTIRHGRIGQMPAWKDILGEQGVKEVVSYTLSLSGRSVNAKEAEAGKARFAVCSACHGTDGKGNPAFGAPNLTDNDWLFGDSRAEVTETVMNGRSGVMPAWINTLGEEKIQLVAAYVWSLSNSENK
The following text describes a protein:
Function:
Required for anchoring microtubules to the centrosomes. Required for ciliation.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MSATEEDTELRDLLIQTLENNGILNKIKAELRASVFLALEEQEKTQNKTPLVNESLKKFLNTRDGRLVANLFTEFLQFFNLDFTLAVFQPEASLENAYDDRNHLAKDLGIVDSESVKSGPLVLELVRRCHQKDKIISGGESDKPVSVPKELSPKQLSEAQKKFDLYDKDKNGEISKDELRTLFLDLFPHFHRSMLERYVSDEFKAADKYFNNGINFHEFIGMYKRLFIHCRSVVTHDIPDIIHSPRRSLEAKASSQVNNNQQTDDHIEKNTLLSRESKQKHENHLTFDTKPDFNLNKISFDNEERKTELEEDYLEGDSFFDDPIPKPEKMYGCAEGADVSLKTGVRSNSMERKNEPPKHDGSVPALASLPPLKMETGSRFGAFNTKESDKTGDEDDDYIDDFNSTSQRSDKSDVSIGEEIEEEELSVDDFVTSEKLEDLTLDHTISQTSDVADYLEDVS
The following text describes a protein:
Function:
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Mediates resistance to oxidative stress. Controls the activation of the CEK1 MAP kinase. Influences the molecular weight and polymer distribution of cell wall mannan. Involved in invasive filamentation into semi-solid medium and plays a role in morphological dimorphic transition which is a differentiation program characteristic of C.albicans and which is known to play a major role in pathogenesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGFSLSNFTSDPFAISTVSFGIMAWVVAIAGAASSKQENFPHFSWWGISYQIVIILIIFVLYANNNIELYKFTLVGLVSIAFIYTTNSTNNLIYNSNSAGNLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSLRGQGHEQLGSGSHNHNANNANNNIPIGAGNAIIGKGEMSPYDDRFAASGVNQPTSESLRLASGPQMGNGPFTTTGAIINPNLQQPLSGSIGGSAHHTPTNINNNNNNNNNTGYMTSSHLTGLENFSSPHVPGSGAGAGLGVGAGRDLTHNSNGGGGGSGGGPASANNSNNTNKRNTIYTDSETGTGITFRYKAKALYSYDANPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLDT
The following text describes a protein:
Function:
Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MIFAITFFMGITSTLAAVLEPMSYYQYTQFQAPLSWEDITGKGLKQALDSCQQSFQWQRWNCPSQDFVQKNSKPEENSPNREDVYVAAISMAAIVHTLTKDCANGVIAGCGCTENALNVPCAHEPTKALEQYEKHFGSGSGAIGHNRRVVGALLQRSLEQECRCKQPGAVQGECQEEECVAVLKPFEAIAQDLLQMYDDAIQLEGASSNLKIMWQNIPLDSLVFMQDSPNYCERDATGLWKGTRGRQCSKDGSGSLEERLSCQQLCRVCGYRVRSQHVRTERRCNCKLVWGFRLQCDVCVQLERQYSCY
The following text describes a protein:
Function:
Chromatin remodeling factor. Acts as a 'reader' protein by binding to H3K36me3 and H3K36me3 to control histone H4 acetylation. Increases the transcriptional levels of the flowering time genes FLC and FT. Binds the chromatin at the FT promoter upon interaction with CO (Probable).
Subcellular Localization:
Nucleus. Note=Localized only in the euchromatic regions.
Sequence:
MGSSSKEETASDGDTASGGASPSNDGRLFSEGERVLAYHGPRVYGAKVQKVELRKKEWKYFVHYLGWNKNWDEWVSADRLLKHTEENLVKQKALDKKQGVEKGTKSGRSAQTKTRSSADTKADKDDTKTNAAKGKKRKHESGNEKDNVTAEKLMKIQIPASLKKQLTDDWEYIAQKDKVVKLPRSPNVDEILSKYLEFKTKKDGMVTDSVAEILKGIRSYFDKALPVMLLYKKERRQYQESIVDDTSPSTVYGAEHLLRLFVKLPDLFSYVNMEEETWSRMQQTLSDFLKFIQKNQSTFLLPSAYDSDKVSDGKGKGKDD
The following text describes a protein:
Function:
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.
Subcellular Localization:
Membrane.
Sequence:
MASQPQRVLISGCSSGIGLELAVQLAHDPRQRYQVVATMRDLGKKEPLEAAAGEALGKTLSVAQLDVCSDESVTNCLSHIEGGQVDILVNNAGVGLVGPLEDLSLATMQNVFNTNFFGAVRLVKAVLPGMKRRRQGHIVVVSSVMGLQGVMFNDVYAASKFALEGFFESLAIQLRQFNIFISMVEPGPVITDFEGKLLAQVSKTEFPDTDPETLGYFRDLYLPASRELFRSVGQSPRDVAQVIAKVIGSTRPPLRRQTNARYFPLTALKALDPSGSLYVRTTHRLLFRWPHLLSLGLRCLACGCLPTRVGPT
The following text describes a protein:
Function:
May enhance the cell surface expression of odorant receptors.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVSWIISRMVVLAFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIVFALFTTAETITDMLLSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEREIDEYITQAKDRSYDTMMRFGRRGLNIAATAAVTAATKGQGVLSEKLRSFSMQDLTLIQNEDELQLEGGDDTHTAATLPRAKTATRTVRATPVPADTESQHSSRSDDQSDSRTEHSDEDAADKAPKRIAITRAAKKPAAAKTEQTTKTVKKAPKKKPTTANNVAESP
The following text describes a protein:
Function:
Catalyzes the synthesis of jasmonate-amino acid conjugates by adenylation. Catalyzes the conjugation of jasmonate (JA) to Ile when expressed in a heterologous system (E.coli). Catalyzes in vitro the conjugation of jasmonate (JA) to Ile, Phe, Leu, Met, Val and Trp. May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin (By similarity).
Sequence:
MLEKKATRSTRVDGVSGEAVIEEFERVTRDAANVQRETLRRILAENGGVEYLRGLGLAGATDPATFRARVPLATHADLEPYIDRIADGDASPVLTAKPATSISLSSGTTQGKRKYLLFNEELVKSTMQIYRISYAFRNREFPVENGKALQFIYSSRETRTKGGLTATTATTNVYRSEEFKATMRDIQSQCCSPDEVIFGPDFAQSLYCHLLAGLLAAGDVQIVSATFAHSVVLAFQTFERAWEDLCADIRRGEVSPSRVTSPAVRRAMAALLAAPNPGLADEVARKCAALSNWYGVIPALWPNARYVYGIMTGSMEHYVKKLRHYAGGLPLVAAEYGASEGWVGANVEPGTPPERATFTVLPDIAYFEFIPLKPVAGDGGYAEAEPVGLTEVAAGELYEVVMTTFAGNTRSSSSCMTLVAYYYLQSKKWMNICRFCISVHETSRNLVTCTFAATGHIMFAQK
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MLRSIIGKSASRSLNFVAKRSYAEAAAASSGLKLQFALPHETLYSGSEVTQVNLPAKSGRIGVLANHVPTVEQLLPGVVEVMEGSNSKKFFISGGFATVQPDSQLCVTAIEAFPLESFSQENIKNLLAEAKKNVSSSDAREAAEAAIQVEVLENLQSVLK
The following text describes a protein:
Function:
Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon.
Sequence:
MANTTMGVKLDEATRDRIKSAAQRIDRTPHWLIKQAIFNYLEKLESNSELPELATTSSLSLQDTEDAIPQLTENTHQPFLDFAEHVLPQSVTRAAITAAYRRPETEAIPMLLEQARLPADLAQATHKLAYSIAEKLRNQKSAHGRAGMVQGLLQEFSLSSQEGVALMCLAEALLRIPDKPTRDALIRDKISNGNWHSHLGRSPSMFVNAATWGLLFTGRLVSTHNEAKLSGSLNRIIGKGGEPLIRKGVDMAMRLMGEQFVTGETISEALANARKLEDKGFRYSYDMLGEAALTEADAQAYLLSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYERVMDELYPRLLSLTLQARQYDIGINIDAEEADRLEISLDLLERLCFEPQLAGWNGIGFVIQAYQKRCPSTIDAVIDMAQRSRRRLMIRLVKGAYWDSEIKRAQIDGLEGYPVYTRKVYTDVSYLACARKLLAVPNLIYPQFATHNAHTLSAIYHLAGQNYYPGQYEFQCLHGMGEPLYEQVVGKVAEGKLNRPCRIYAPVGTHETLLAYLVRRLLENGANTSFVNRIADATLPLDELVADPVSAVEAMAAAEGQLGLPHPRIPLPRELFGKDRANSSGVDLANEHRLASLSSALLASASQVWRAEPVIDAEQDNGDALPVINPAEPADVVGYVREATEGEVSRALDAAARAGAIWFATPPAERAAILIRAAELMENQMQTLMGILVREAGKTFSNAIAEVREAVDFLHYYAGIVRDNFANDSHRPLGPVVCISPWNFPLAIFTGQVAAALAAGNSVLAKPAEQTPLIAAQAVRILLDAGIPQGVLQLLPGRGDSVGALLVNDARVRAVMFTGSTEVATILQRSIAGRLDPQGRPTPLIAETGGLNAMIVDSSALTEQVVTDVVASAFDSAGQRCSALRILCIQDDVAEHTLQMLRGAMAECRMGNPERLSTDIGPVIDAEAKTGIERHIQAMRAKGRKVYQAARTNSLDEKEWQRGTFIKPTLIELDSFDELQKEVFGPVLHVVRFQRQHLNELVDQINASGYGLTLGIHTRIDETIARVTEKAKVGNLYVNRNMVGAVVGVQPFGGEGLSGTGPKAGGPLYLYRLLSSRPDDALANTLAHQDGEQQQNVAGREALLTAHRAFTQWATEQQHDSLATLCQRYASLAQGGTVRLLPGPTGERNTYALLPRERVLCLADTESDTLTQLAAVLATGSQVLWPENDVQKALLPQLPTEVQSRITLTHDWQTANITFDAVIYHGDADQLRTLCEQVAQIDGPIVSVQGFARGETNILLERLLIEHSLSVNTAAAGGNASLMTIG
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MEQIATTTDGQVVMQAVQGVSPQQVQVMQMNTGQVIQGANGQQIMVHAVPQSGQIQVAPAGTQSLQQIQVLPVSSLQTAQGQVLLQQPQQAQIVQSLDGHTFIYQPVAIDNTTLQQAQPTVLNINGSLVQIASSPPAAATTTVAQPAVTSPSQTVVPQIAAASGNQLTMANGNLVMVRNAADMVPGSSGTQFQRVPIPGTTEFLEEEPLYVNAKQYRRILKRRQARAKLEAEGKIPKERPKYLHESRHRHAMNRIRGEGGRFHSGSVKKRREEMERAQQQQQQSQQRSIGVPYNNIELATPIIIENVMPDIIKTDPLSIEGN
The following text describes a protein:
Function:
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene (E,E)-alpha-farnesene. Is also able to convert geranyl diphosphate (GPP) into a mixture of monoterpenes including (Z)-beta-ocimene; (E)-beta-ocimene and allo-ocimene.
Domain:
Contains several highly conserved motifs that are important for catalytic activity including the aspartate-rich 'DDxx(x)D/E' motif and the 'NDxxSxxxD/E' motif, both of which are involved in complexing metal ions to coordinate the binding of the isoprenyl diphosphate substrate in the active site.
Sequence:
MNILLKDFKYPESWNKSPNQSNQYIDQVFEDTNKIGIYELNNQDHYLYVENLLNVTSYLYPTFDKEQLRLCATYLHWLFLIDDFLEDEYNTMSEKQNDVIKSHAQILLTGQYLNSDVDVKPSEKLTMFLQNTSKDWAIKYNKFDVHNIYMTTLFQWLYSVYPLNKTTESTKPIHMDLYTFIRKVNIGVAGSIIVGLLADKDITDIDISKIWLNPIFTRIMENSTIQIGLVNDCASYDKEYANGGHITNPLYFLQVRDNLTFNETLNFIVNKCNQSIDEIIKDEQLLLKQLKDQGYTENQLNQVNIILNYNHNLIQGNINWSLISKRYNNHDGKPFIFENTKSKYI
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MDILERFFPRVSCLEDFLRDLNGCPPLCIPKDKAGYRAFLQSTLVGIPSCHISYQGPLDYTQHSDHMEVINRVLLRLQHQGKGGKNVLLNGFTSWRSEGDYAGILPSINVPNNNSNQLRIPFWSKLLSRIGDELMMHILENLSIFGAAPPSCYIQLTGTPLSMLISSLPTNTPSPAKTSTVEQRFKQRRKSFQVKDAAKGGKVDRCDGDGRKVHGKRKRDEDAGCNQGDANVAKFRRGEQGMRQPTHRKEAENREEFKKDPKVLESMITGLERSYYILNACYSRTAGRTLLKHDLISKLPASNSGAQMLTQHIFNSPHSSAMAPGKYDKTVSYDGKGKGEIGLQGDDKGRKRKKLQRTCRRLIKVQALLKTFLTQHRKLKLNSILNHQCPLNLPQDSPPSDHTNTSHQECSTGTLGQRSHTKKTSLPPPSSGECASCEKSLAELREESMLEGYSPKVFHRKRPKQSVLNNTQVSSVKQFDGTRMEESVIQVDDGRGGIEQRRKDDGRKGSTKKVGESIREGLRDRVGLGGTEERVGNVRRKKKGEMVKSTKAQSTTDERKFDEKNGHSKSHPGSTKDFDVSQSRSVRMEMDENATSSTAGDVLQETDSIPSQPHMRLRRETNTETETGVGLPSGEVTVDNDDDDTLTVSGKILSQPDKRLRGKTNMRAKRNTLLIGDGVQRESQRDRKIQRKSKTKTGRQLPSDTAAPSDHPKRNETPDSMQFQLKRKMKKTTDTKDKPRMRLPNDAATLIKMKTDPWQVCLFLRQVLLKVVPDELWGSVHNRNVFLKGVKKFVQLGRFERLSLRELTEEIRAEDCDWCQLEKFRGRDPPFTSVVKQRQLVTDFFHWLMIGYTVPLIMMCFYVTENSSSRNQLVFYRKPVWLLLEKIGIQYYVSHGVMKPMKENDVKKLVSAGLTLGFSRLRFVPKTKGLRPITRMGKSVIEEKKGLSVRLLLQDLFDVLTYHKINQPSVMGSSLLGIDGIYHKVLKFIKDRKERKDTRPLYFVKIDIEKCYDSIKHSKLLQIISMLLQGHDKPDEYQLQRYVTVTRAASASTGLQKRSHRHVTTELSSFHRQLIQMAQHGKIKNAIIINQVHTVKVTPKDLLQRLKQHVMADIVKSGRKYYWRQDGISQGSILSSLLCSFFYAHLERCYLSDIDQEGLMMRLIDDFLLITPHHDKAQRFLQLLLSGVKQYGCSANPSKTLANFDFMHDGQLVPRSKELFPWCGIVFKTQTLNISNDYTKYNNVSIRYTLTICTDRDTSLHLMRIKLTWSLKAKNVSIFMDPLINSFLTIVINVYHLLLLLAHRFHSYYYCLASYIKQNTPPLQFYNIWASCVRIFHACTVSKLRKDDQGERETTFPLTVNTVNWIGLKAFNTKLSKHKGLYHPLIKLVRKHRQKAALKMGKAMLEVLEEMTNPALPDDFMKMRR
The following text describes a protein:
Function:
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (By similarity). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity); In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (By similarity). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging. The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (By similarity); In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells; In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.
Subcellular Localization:
Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane.
Sequence:
DLQNVNITLRILFRPVASQLPRIYTSIGEDYDERFDAGELITQRQVSDDLTEREFTEAVEAKQVAQQEAERARKLEAAEDIAYQLSR
The following text describes a protein:
Function:
Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
Subcellular Localization:
Nucleus.
Sequence:
MSTSSSIESALRFRADRLQNIRVTHDGTIARRTNTSFFTRGLVFTNRPIRINEKVTFKLMELSEGLGGFVYVGFTSRDPDNLQGVTCQHLAKGSGFWSWFFPKELCGTRSTLFYYIGEGGEVHYGVDGVEKGLFEGVVRTNQSLWPLFDIFGNSSGVRLIEAESRETRPKARANRKLVPMMLHETHSRNVRIDKNVAQRLDAKYTQGYIFSKQPIKSEQSIVIQIAPNGRGRFQGFVHLGVTSCDPALLNRDDLPDNVNSLVDRPEYWVLICDFSNLNCGDEIGLDLAHDGPITFHLNGGKFKGVVHVDATLKLYLFVNVYGSCQDVHLSTCAEQSKVEEKECVVCYDNVIEAALYRCGHTCMCFECAVEQWQGKGDGHCPLCRAVIRDVIRINK
The following text describes a protein:
Function:
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
Subcellular Localization:
Secreted.
Sequence:
MKLAYLFLGPMALLLLAGCGCVLGTYSGDLRTFVGCAVREFTFLAKKPGCRGLRITTDACWGRCETWEKPILEPPYIEAHHRVCTYNETKQVTVKLPNCAPGVDPFYTYPVAVRCDCGACSTATTECETI
The following text describes a protein:
Function:
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MSLLHRADATALRILREQHVESLAMSAQTGPINYIKKTFKDIVDTMPDRRNTFLMLVTLCTFFVGWRTAIAVTDCESPLVVVLSGSMEPFMFRGDLLVLHNIGEPTMGDVVVFSLPNRTIPIVHRVHRIRLLEDGVTRLYLTKGDNNEMDDRTLYPRGYHWVEKKDIIGKVAVLVPRVGFITLIAEDHSWAKLVLVPLALIWCWYTGM
The following text describes a protein:
Function:
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
Subcellular Localization:
Cytoplasm. Membrane. Mitochondrion.
Sequence:
MRGAGPSPRQSPRALRPDPGPAMSFFRRKVKSKEQEKTPDVKSVKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQEAKSSLSKTLEQVLHDTMVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKPETTAAFVTESLNRRLEDSGSAHLEGIDLNNRTSNSQNHLLSQESDSAHLLHLETARTGTHWGSLETQESSRLMVASRSSPSSPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEDGQVDPNCFVSAQSIVFSAMEHEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKSSVKKASVKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVKKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAQCDQPLEKSTKI
The following text describes a protein:
Function:
ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MADLASRITKPDEAPAAAPEAAPVSAPASEEPKAPENETSIEESQSNLVKNEYEVEIKLSDLQNDTESPLYSVSSFDELGLPEAVNRGLLAINFKKPSKVQEKCLPLMLSDPPRNMIAQSQSGTGKTAAFVLTVLSRIDLSKPHQPQALLLAPSRELARQIQTVVQTIGQFCENLIVEAAIPGAISRETGVRGSVVVGTPGTVMDLVKRRQFDISQLKVLVIDEADNMLDQQGLGDQCVRVKNMLPKTIQILLFSATFPDKVLRFAERFAPNANQMKLKHKELTVKGISQMFMDCPTEKDKYDILCKLYGLMTIGSSVIFVRTRETANEIQKRMEADGHKVSALHGAYEGQSRDVLLDEFRSGRSKVLITTNVLARGIDVSSVSMVINYDIPMKGPGEREPDAETYLHRIGRTGRFGRVGVSISFVHDRRSFEALSQIAQFYGIDLIQLNPNDLDDTERKVQEVIKSSRAQAEYVPSATDSAV
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MRQSGADFTYSTAPIAKVRRVEFGLMSHELIKEWTGDIEIKELQTNELDGTPKQNGLNDLRMGVNTNAQKCKTCGETKYCQGHFGRIELNKPVYHVGFLQIVKKVLKCICHSCGKLRQPQSEDAWQSFQKAKEHRLNRKRLNEIVKLLGRIEKCETSKHKQEENQGNDDFCGEKIPTRIQAINGQIKIQYNTKEAAKELTAERCLEIFKKIRDEDAIILGFTKDSRPRDLIIKFLLVMPPQVRPAIEMNPARIAQDQYTQIYKSILQKNNEIANCSSDAERVRLAPELMREVAKIIDSEKAGKIKMKSTQPLKSIRARLKGKEGRFRQNLMGKRVDFCARSVISPDANLGMDELGVPQIVADQLTIPEEVTEYNLERVIQLAKTNKIKYVIVPITDPRSKQRKFQALYFDFTDTEDQIRQKINQGVIVERCLQDGDFVLFNRQPTLHRMSMMGHRVRILPYSTFRLNLSVCTPYNADFDGDEMNMHVPQSYETIAELKYLAHVPRQIVTPKSNQPVMGIVQDSLLGCCLFTQRDTFLTRDQVMHLMMWNEQFTGELPMPAILKPQELWTGKQIMSMIIPQSINTERGIREDDLRKPNWNADDKSLCIQRGSLVSGIFNKELVGQGAGSVVHLCWLDLGAEKTLEFMTSCQRIVNNWLIMHSFTVGCQDIAPHINLVAETEKRSKEQDEEYIKLLQIFLDAKKIQDNRYHQKGKRIMDSFEYSFNMKLNKVRDDINSKVTETIDQIRNCMYKMIWAKSKGEASNLAQITSLVGQQNLESKRIQFGFAYRTLPHFSKFDYGPEARGFVASNFFKGLKPTEFFFHTMGGRDGLIDTAVKTSRTGYIQRKLIKAVEDVFVRYDSSCRDSVGAVYQFHYGEDKMAAEFIEHQEIKCVNLSNAQLEEKYELIKEQWFGSEIRQKYQNILTEDVIKDIEEDFEGQALLKGEFDEIKKIRNELRRLFLIDSAPKEELFTHYYLVVNIERIISTIKINKKISDREKCRLNPIYVTQQVDELIQKVDKLLSYDLEERKDCINLFRTHLKVSLASKDLCCRHRLTPEAFQELISEIIYKLKKSMAHPGEAVGAIAAQSLGEPTTQMTLNTFHKSGVTGDKNVTLGVPRLQELLDASKKTKTPSLTIYFDPPLEYAELELKDDKDKKSYLKTEQLVHPHKQDDFTQSMLVQMQGRILGQTFGQYIIKSEIYYQSDPNNPLHITEDQEDNFTDGIFDQDEAKYKWILFLHMDHQKILSNLETWDKIRDSIPKILDETQVKFGISSQNTIVDPDSMNHKYIQIKYFHDYADQKKFKPERGKGNFDDEIAFDEENKTKTYVDTPYTILKRLEETIRGYSLGGISKITRILHSQIEKQFYINNKTGGFLKQANVDGKGKWKIIEKYLETEGTNLKEILRLEHVDQRRTTTDDVYEISQVLGIEAARAALVGETRKIFNHYGIYINYRHLYLLYDWMTHRGRLTAVNRNGINRIPEVSVLRKSSFEETVEILYDAAVFSEIDHMRGLSENIIFGQLCPHGTGCFELMVNAKNVKEFKLKSSHADKFTQGGEYLAEQSPYDQNQQTPLMLNTPGPGVSQGFIENSPYTPYHKSPANFATPFGREYTPNSSHCSPFYPNTPLMPNDPYQLSPVGSDSGIQQSVQKQANVSDSHSPGSPHYTSHTNSPSPSYRSSERATSGQRSSSPILNSSRSPNYTSSVYNSPLSPTNTGSPRVPTGSPHSPQGSIFTTYSPVYQPGGGTGNQYEQEQ