lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability.
Subcellular Localization:
Nucleus.
Sequence:
MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKVEAPASDTQLETEQPPGLPSGDPPAELQLSLSEQSASESAPEDQLDREEDSRAEEPKAEKSPGSESKVPGCKRGSPKADSPGSLAITPAAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLMHYSSFEVGGPAPAAAAAAAAAVPYLGVNMAPLSSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPTGLAPASAALNSKTTSIENLRLRAKQHAASLGLDTLPN
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MREMEYVWILVFAGILLVIGLVMISLNALLGPREPQIYEDYPYECGVPLYDKDAQTTFHQGYYLLGLLLLLFDIEAAFLFPWSVVYRYLGVFGFIEMFIFIFILTYGLLYAWKKGALDWQFEIEEV
The following text describes a protein:
Function:
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Subcellular Localization:
Secreted.
Sequence:
MRGLLPFLFLLSFFLSPIQAQPEGREEELEETWSEDRDQAPPRVVEESEVVGAENEAGLAAGTYKNRDSPSTGEPPAQSRSPIYFSTAGIPDCGPPSAMRTLYLLLAVLFLVLSQGNAGYGQRSDSYQCHSKRGTCSFSNCPLFRKPYGTCYNGKAKCCLRR
The following text describes a protein:
Function:
Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity.
Subcellular Localization:
[Isoform b]: Membrane; Single-pass membrane protein.
Sequence:
MEPTASQGIQYLRGGVEWILKLLNLHILNVKHENKPLLFRLIDLKVYIPSSVSTVRWSSGASSYVILGEYRKMRSAVALLFLLVAYCGGVVHAGEIVAELYHTNVTVKWHTDYERQLVDFSIWFGASTPDVLFLGFSDFGDTNNSDVLMYYNSKKEIKDAYTNRDFKITSDLQQDFQLLRKRKDHIVVRRKLTTCDSRDYAFLPGTTQFYIAASWGSTNLVDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNEHLVHHMEIFMCRDEVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKNLPEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRMQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMARPTFVSGSFITTRDRFQCPAINDMINFE
The following text describes a protein:
Function:
ROP effector binding specifically activated ROPs and linking them to the microtubule cytoskeleton. Involved in ROP-regulated polar growth. Involved in local disassembly of cortical microtubules when associated with ARAC10 and KIN13A and conversely also mediates the elimination of ARAC10 from the plasma membrane by the cortical microtubules. Accumulates at the plus end of shrinking microtubules. Targets KIN13A to microtubules.
Subcellular Localization:
Cell membrane. Cytoplasm, cytoskeleton. Note=In xylem cells, preferentially colocalizes with cortical microtubules located beneath the secondary wall pits. May be associated to the plasma membrane through the interaction with ARAC10.
Domain:
The N-terminal part (1-122) is necessary and sufficient for homooligomerization and for binding to microtubules while the C-terminal domain is anchored to the plasma membrane.
Sequence:
MQTPKSRPGSLELPQKKSPLPAPKVVRRLKPSGAESDPKTKTISKTQIPKVVADRRSARIPLNEIQKKRTGRIPELESTISQLQEELKKAKEELNRSEALKREAQEEAEDAKHQLMDINASEDSRIEELRKLSQERDKTWQSELEAMQRQHGMDSTALSSAINEVQKLKSKLFESESELEQSKYEVRSLEKLVRQLEEERVNSRDSSSSMEVEELKEAMNLSRQEITQLKSAVEAAETRYQEEYIQSTLQIRSAYEQTEAVKSRYSQREAELTEELNRTKDEIEGLRKELMEKVKEDESTGDLKKLESDLMEVRGSLMDKEMELQILRSAMEKKVETANTEAMEAELKRVKIQCEQWRKAAETAASILNNDEERTDSIETSKMLKKFGVLLKKNHK
The following text describes a protein:
Function:
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MAGNPVKWVYLILASYLFFDLVLAADTHIARKTYIVQMDKSAMPKSFINHLEWYSSKVKSVLFNHEKEGDAGDNDRIIYSYQTAIHGVAAVLSEEEAERLEDEHGVVAIFPDTKYQLHTTRSPAFLGLEPEDSTSVWSQKVLDHDVVVGVLDTGIWPESESFKDTGMTPVPAHWKGKCETGRGFEKHHCNRKIVGARVFYHGYEAATGKINDQTEYKSPRDQDGHGTHTAATVAGSPVRGANLQGYAYGTARGMAPGARIAVYKVCWSGGCFSSDILSAVDRAVDDGVNVLSISLGGGVSPYYRDSLSIAAFGAMEMGVFISSSAGNGGPDPVSLTNVSPWITTVGASTMDRDFPATVKLGNGRTLIGVSLYREQRIRRSINKQYPIVYMGSNSSSPDPSSLCLEGTLDRRLVAGKIVICDRGISPRVQKGQVVKDAGGVGMVLSNTASNGEELVADCHLLPAVAVGETEGKALKNYVLTSPKATANLAFLDTRLGIRPSPVVAAFSSRGPNFLSLEILKPDVVAPGVNILAAWTGDTGPSSLPTDRRRVKFNLLSGTSMSCPHVSGVAALLKARHPEWSPAVIKSALMTTAYVHDNTGNPLRDSSTAAPSNPYDHGAGHINPIKALDPGLVYDIKAHDYFEFLCTQSLTPAQLKFFSNRSCQHSLANPGDLNYPSISAVFPEKASITTLTLHRTVTNVGPAVSNYHVVVSPFKGASVQVKPQTLHFTRKYQKISYKITFTTVSRQTVPEFGGLVWKDGVHRVRSPIVITWLPPL
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MAGLFGWLSKKEDTNYEKILLELDDKIRRSEMRLAEFGLRERRLLYAWFFYTLPAYIIVLAVYAMYYRMSDGEPWKQFLIKSLPVVVVPIIIYLVRAGIIAWYLRCRNVEEIRLDELRTKQNDKITELKLKTSFYLTKGLIERYDNPKSKGGKQRKGSENPSGHDQTSSGSRHHPQANRQPQSADSRSEKTQESHGQRPHTQMSPQRRASPSVSENGPHSRQMLSNHPGFQQMDNAQHTPLQRQQLLHQQHIRNNDQLTPSHVVHQQQQMAALPASVNWFDSLLEAIIGESDGPQHKYALICEKCFTHNGLVLPNEYLVSRFKCMQCGHFNAKKTSAYAFDFNHSAEQSSHTFNSPSPPSSPVSRLRRRSNSICSNTSDASFSPMHYDNGSRSQFQTSSVENLTEEQRSDAGTNENMTLQQHEETVGNNDTASEKHDSLDSNELPTKDVSSNQDALSDTSTPQEVLEVGQQVSVKVLEVNEKDERISLSIKEIEQDQAEKEYKQYEKDDEQSGFQLSDIIGDKLEKFKK
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSEQTAELASHSMSLQLCRAARAIIEDFNSLLGVLSSNQFTTESKILPHSTIGKHIRHALDHFLLLLAGLQDLLDTRRSNCIDVTIDYDHRQRLTLLETDPKAAQTEFARICGKLEDALLYLDMNTSVCVLATTEVSGLPIKLASSMGREVWFLDLSQHGFVDFHPLFPQSITPALAFLFLIVSFLSASIFFIKQVGTNKYSRNICQEILFAVIGSLSFGFGLVFMFLAVGIYV
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation (By similarity). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction. In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (By similarity). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Domain:
Binds cholesterol in a cavity lined by the transmembrane spans.
Sequence:
MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTTLLYLELGDKPAPSTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGSNTLTTLTTAVLRNSLCPSSSNSFTQLLKEDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
The following text describes a protein:
Function:
Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNKVGILLILFILSLILPFTALYLAGDTHLITVKDIINFLLKGTTGNEFKDIIIKDVRLPPIIGAVLIGLTISVAGLMLQTLFRNLLASPYTTGISSGVLMVVALVIFIDSLSHLFEIFGEKSILVAGWCGGIFSMILLIIIALRVREANGVIIVALLLSYFFMGLRAYLIANAEELKIQEYWGFTIGSLSKITLGDVIPMTICSIIFIIGVMFLIKSLNALLFGEQYAKSFGLDIKKTRLLVLFFASFITGAIIPYVGLIAFIGIIAPYLARPLIKTSDHRYLVPATMFLGVILMVSCHILSLKYYLPIHYLYGINRPASPLPIGAVLDILGGMLVVYLVYKGEKKIKID
The following text describes a protein:
Function:
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MENTKRREFSHPYTPYPIQVDFMEALYDCIESYKVGIFESPTGTGKTLSLICGSMTWLRKNKAQLAVSTASADENEPAWVLEQTIQLAREEFSRNREMLQKRLDKMRRKNMRARISYEQGFKRAKKAPEPVDDSQFLPEDYSEVIKPEVQRLLSALAPPVENDFQEPVKIIFASRTHSQLSQFVGQMQHTTFPPSSDLQDLESTKLISLGSRKQLCINPRVSHMNSVQAMNDACRDLREGKKGGCKYYKNPHDALGKVDINTFRDTTLAEILDIEDLYKLGKHTSTCPYYASRASIPASEVITVPYQILLSRSARKAIDLPVKNSIVIIDEAHNLLDTITSLHTMSITKSQVSSASSGLQKYQHKFQNRLNSGNRVNLGYLVNMLQALEVFFEKAQKFHKKETAPGTPVTTSSLFDGSTADLINVNRLEKYIDESKIVFKIESYLEHVNGETQEKSHSSSLVLSSVMEFLRQVNNPDSEGVLCFDGPTKLKYQLLDPSEPFKDIVENARCVVLAGGTMEPTGDYLEYLLPYLSQDQIKLFSCGHVIPPQNLSVQVIPNGPNYSFNFTFDKRNDEKMILDVAITLLVYSKIIPEGMVVFFPSYKYLEQVVAVWKKAKKDGKNIYEILNDQKRIFVESQHDSVEKTLSEYAEEVPKGAILLSVVGGKMSEGINFSDGLARAVFMIGLPFPNLMSAEIIAKRKYIEQSVSEKMKAKGVSAKEALEASKGAARDFYMNICLRAVNQSVGRAIRHANDYACIFLLDGRFGKPEIQKKLSKWMREGIREGSFKEALGEVQQFFASHEKN
The following text describes a protein:
Function:
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Sequence:
MQRVAITTLGCKINQFESAAMTESLGREGFRLVPFEDEADIYVINTCTVTARTDAESRRLIRRAMRRNPAARVVVTGCYAQVAPDAVGELPGVSLVVGNSEKKGIAGLLRDAVPAEKILVSDISRQRTVEALGLESFAEHTRAFLQVQNGCDAFCSYCIVPHARGRSRSVPFRDVLEGIGTFAYQGFREVVLTGIHLGAYGADLEPPASLLDLLEAADAEALVPRLRVGSVEPHEISDGLIALMARSPVICPHLHIPLQSGSDSVLERMNRRYTAAFFRERVERLAAAVPDICIGCDVIAGFPGETDEEFAATLALLEGLPIAHLHVFPFSRREGTPAARMPGQVDGKIVRERAEVLRALSDRKRETFHRRFMGRDLPVLVLNGRGKEVTGLSRNYITVRIEAVTPPPEGEVMVRITGVEADGVRGIISEPVRK
The following text describes a protein:
Function:
May play a role in apoptosis regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSGLAREVIKWLQSLDLSVSVKYPKRDFANGFLVAEIFSWYFPQEIHMHSYYNAPSLPKKIGNWSQLERLFKKHGIDIPKVLIDGTMHSKPGAAILLVERVYTILTNRAVKRTPVKHELDFSDNGYQSELPPHARSTASQALKNNLAITEFDTDPDQIFRMQKAQSILNNHIENRRKEREENPERFGIRPSIGQLTPRKLPSVKTRKSQQRDSLIYPMDSANGDERHSNDTVESGQVHFTEIQVKQLNRNEQNALRQSLYAAS
The following text describes a protein:
Function:
Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MPHVSSSGGDDLGSTDEVKVFKDEGDGEDEKRSSENLTEEKSSLIDLTESEEKSGGSYSSNKNVSRADHSPVFGKVEPVPHTSSFNMGYLVSPYSYANGAAGPIPVSMASKMGLAPTGHPGAALPFFCHNGDPLSQPPPAHMGIPPYQLDSKTAGSMGEYGGGTAPPQPISPADWRRLGPLLAAGLTRPPMYPFPAGQYPYPILSPEMSQVAASWHTPSMYPLSPGAGFRSPYPSALPISTSSLPSDFYRFSPTGLIPPHPGLSPHPPHLSSHPAIVTPGPKQELPDLNHSDPARVGGGHARNEVQDWLSEARPLAGRLPGNLISFDIPLILINAIMDTTEEPLNLTIKKMPIAIVAPFTIVEPKLNKHEDLPQDLSMKLSKNNDQCLDLSKTKETNLEKSNLNHNEQLRKYLCKNEDETKNHYSKNTYNEQGNKLADLYKSLGPDSVYSFINNLTDRKLLSAWYMNTVLGHQNPYLALPKTDSSDNRILNNLLDKKPYSTYKFPTNFDALIVNEMRSEKPESKKDKKGSQVDHKNNLGDSKNNQDGNNGEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYEKARQERQLHMQLYPGWSARDNYGYGTKKKKRKKERTPVDAPPTTNVHTRHGRMGRRPAGRSRFLRLLLVPAWHALGREEQAKYYELARRERQLHMQLYPDWSSRANATRGKKRKRKQDPADGGNSMKKCRARYGLDQQNQWCKPCRRKKKCIRYMEAGDGNDGNQSDDNLGSCGSMGDAHTPPEDDAESLNQSISSPGALSGLSSLTSPGGMVLPSPSTSVASPSVSVASPYMLQSPLTPHEAFDVKLPPPPHPHHQPPRNPVGTNPHDINNPLSVNQLTGQCVRNDSSDTNGKETRSIISVT
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MALAITDLAAFYEILSGLWVRNGLQIKGQAMSYIQCHFGNSMVDADIYLLQICATQLSPTLVLPTIFERFHVMELLSMNPLLKSNFLEGEQESTMLESCLTFIASLMSIRTNIGANESDLDRLEMVSLLCMSDRTHSQLMELLPEKCGAPQNKDFDAILAQVADYKAPNFEASGSMQQGIVRQSGKYPNYSSGTLWPPFRLPIATHLNYEDPRKVLLSRTFHAILFVLLYKATHSPSLVSEQSLALVIYLLDMAVSLVHQTKTQGNEVCIREPIIHLPDDRVDLQLNDWFSTDSLAENVITVVNNVTLTTSTAVTVNSTEAAELDLESSASSTSSTSEGESSDQDMDLDVPEVSGANILLALPETDSQALVPVVSSRPGTSSDMATVSVYRNPSRIGTSSHFRVMPALSAVGQASMVIAGAISPTPTLPQLAYPNIRAITSGNEVTKYTSQISVDSNLSDASPGTIQYEEVTESDNQRERLCVRESIVSLLLRLHSSFNGHSDSYRLPDNSNQGSDIASESGATAEEDGRIGNSSFWIGKVLDKLSRTDLRVRQSIISTKQTLWPPRTAEDSLPSETADELREKEKKRKIKERQQRLLQEFATKQKQFMQQAMAAEDVEMDLEANSVGPTSTITPSAESTTYQGSGLANLISNPASAADPSSAHSTYSASNEEHNLEEYDCVICNQASPSTSDRPMCLVVLLQATSVLAHKRYWPSGSSLALPVCEEDRFNLDKVDSLHVEMNRRVENLRQHFDESSWLTSLNIGYEGGVYVHTCGHYLHLDCHKQYLQSLRSQQRQQSLNVERGEYSCPLCRQLANSALPIATKLYGAKGGRSNEATRMVPCLNQASEEVKNMLGAEPAISPHLGSNLMEAMGRVMEDMTNATFPRFRQITSTPSPASLFLFVQSIARTNLEIELMQRNDSIIQSSGLTMGSSGVNCSSVSNVTSSMHGQAIGESSPTPGTSSASWISPGLELRFSSSPTPSGSSMGSSSQAMSHSTSPWSLLPKRSCLLPLLHVLATHSKILSTRTHQHIWSRTAGLDIGESFSRSLANSSEMEVPLLIQDVPCLLIQMVLILPLPLEQRHFVCLLQRFFNLTMVQIIVQLSCRLGEKKRALYKTVSLSDWNIAALMSFVISNMEDAHLYREDDIDIGFNENKMLNVEGDIHQPLYKMALHFLRIASLLQFHLFGDALPSSGISHTDHEEFVELCSYLNISYEMKFDSCLAPNAIIGHWCHELRKFLGNSRNLLAAKDLLMQHREWRGPRLLTLPNSYDTLFKFYHHKSCPQCNSVPKEPSLCLVCGALVCLRENCCKEENIHEAVQHSIDCGAGTAIFLAINSSTIIVIRGKRACLWGSVYLDAFGEEDRELKEN
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MATPPVLIIDNGAYEIKAGISGVDWEPRVLPNSIARSRTEKRVYVGDEIDNCKDLSGIVYRRPFEKGMLVNWDAERIIWDRLFSPSVLNINPTETSLLVTEPYFNLPNIAETYDQMIFEEFEFQSYFRCAPAALIPYGGLYESDQGIPPQCTIVIDMGYSYTHVVPIRDGQIVWEHVKRIDVGGKLLTNHLKHLISFRQWNMIDQTHVVNSVREACGYVSLNWKGDLETCKAKPRKNPIIQEYVLPDFSANSTSRTGYIRSGPNAAPPEETNGTGEVNGKQKPEEEEQVLWMGNERFAGPELLFHPSDIGLKQTGLPETIAYVISQMPEELRGMFWAHIGIIGGLGNIENLGERLERDLQALCPVEYEIGIYEAFDPASLAYTSATALTSSEVYMSTYPVTRTEYFEQGSSLCRRKFGSFGAPAYNIDPPGFSSGVDARTEVSDDEMEMRYAMGLESKKGGKGKRRKEEEEVTSGNWGGRRRRTTGLGGF
The following text describes a protein:
Function:
Sugar-1-kinase with a strict substrate specificity for the alpha-anomeric configuration of D-galacturonic acid (D-GalA) and ATP. Involved in the biosynthesis of UDP-galacturonic acid (UDP-GalA) from the salvaged GalA that is released during growth-dependent cell wall restructuring.
Sequence:
MSWPTDSELNSIKEAVAQMSGRDKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTQVQLRSAQFEGEVCFRVDEIQHPIGLANKNGASTPSPSKEKSIWGTYARGAVYALQSSKKNLKQGIIGYLSGSNGLDSSGLSSSAAVGVAYLLALENANELTVSPTENIEYDRLIENGYLGLRNGILDQSAILLSNYGCLTYMDCKTLDHELVQAPELEKPFRILLAFSGLRQALTTNPGYNLRVSECQEAAKVLLTASGNSELEPTLCNVEHAVYEAHKHELKPVLAKRAEHYFSENMRVIKGREAWASGNLEEFGKLISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGCCLAFVDAEKAEAAASYVKDEYEKAQPEFANNLNGGKPVLICEAGDAARVLL
The following text describes a protein:
Function:
Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPQGERNVGAIARAMKNMGLEELILVNPRCDYRSVEAQTMAVHAKDVLAQAKVVDDLATALGDRQRIIATSARERILQSPMETPRQALPWLLAPNLKSALVFGREDSGLTNEELNQAHRFVRIPVHPQYPSLNLSQAVMVCTYELYQASLAMETNNQVPGDRLEDGSTMPLATNAQLDSYCQHLEKTLLNIEVLYPHTARSKMAKFRRIYQRAALNSEEVALLRGILGQIDWLAQQIKP
The following text describes a protein:
Function:
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The channel pore is formed by TM3 and the loop between TM2 and TM3. After a sharp turn at Gly-113, an alpha-helix (residues 114-127) is oriented nearly parallel to the plane of the putative lipid bilayer. On the intracellular side of the channel, the permeation pathway of MscS does not connect directly to the cytoplasm but instead opens to a large chamber that is connected to the cytoplasm. This chamber resembles a molecular filter that could serve to prescreen large molecules before they are allowed passage to the transmembrane pore. The TM1 and TM2 helices appear to be likely candidates for mediating the tension and voltage sensitivities of MscS. Gating requires large rearrangements of at least the C-terminus, and is probably influenced by freely exchangeable membrane lipids that bind in grooves and pockets between the transmembrane helices and enhance the stability of the closed channel conformation. In a hypoosmotic environment the membrane is stretched, and lipids may be pulled into the lipid bilayer and away from the protein, which is predicted to destabilize the closed conformation and promote channel gating.
Sequence:
MEDLNVVDSINGAGSWLVANQALLLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSREPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVRLNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRVKEDKAA
The following text describes a protein:
Function:
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Subcellular Localization:
Cytoplasm.
Sequence:
MSRKPFIAGNWKMNKNPEEAKAFVEAVASKLPSSDLVEAGIAAPALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTGETSPQVLKEIGTDYVVIGHSERRDYFHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTAEQVAASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPENVASYMACPDVDGALVGGASLEAESFLALLDFVK
The following text describes a protein:
Function:
Required for ciliogenesis and for structural integrity at the ciliary tip.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MPHKIGFVVVSSSGHEDGFNAKELMVHAPTVNGWRSPRFCQFPQEIVLQMVERCRVRKLQLLAHQYMISSKIEFYISDSLPEYFAPYQAERFRRLGYVSLCDNEKTGCKARELKSVYVDAVGQFLKLIFHKNHVNRYNLYNQVALVAVNIIGDPENCSDESNITSREKLIDHYLGQSSEDSGLDGSYIGKPDYISPLDDLAFDMYQDPEVAQIIRKLDERKREAVQKERYDHAKKLKQAIADLQKVGERLGRYDVEKRCAVEREDYDLAKEKKQQMEQYRTKVYQQLELHDLLDSQMIRKPFDLPLAPIVHSNSPRPQKSSQSLLHREEQAGEKPCAEPAKAQLHSPLNVKLQAAMGPPLPASDSLTKINVDLLPYDERPLPAVLKQQGEVYVEPEKVEEDLVPKGSTAGEPEPLTEKALREASSTIDVLGETLVAGAYSKTWSYREDALLSLYNRLMATPVGTPKEDLKNLLRAAIFLIRRAIKDLVPSVFQTSLKLLKMIITQYIPKHKLGKPETTVTVEKTLPNLLTRTGDSSARLRIIASNFIQELALCKEIKPLQIIPVHLIQPLKQNSSTHLAMSQTDLLARLLKDLGTENSGFTVDNVMRFSVSALEHRIFEIREIAIKIILDMYKKHRTLILEYLPADDGNARKNILYKTLFEGFAKIDGGTTMTMEAQRKATEEAEKQKKEEVKVLQVQLAALREMQAEAQFEKEKESDMGKMKNQDDPRKKAIHSNPPDVPDDHASVANYLDYLCIFCGERDDSFTEEGLDLHYWKHCPMLTRCEHCKQVVEIASLTDHLLTECDKRDDFGKCHRCCEAILKEELPRHIKIKACNPARSEKLANRCPLCHENFTPGEEAWKSHLTGPAGCTMNLRKVYHLQKTQATQLGKAVDSLMAKSGTSGSKFGSKIPTPKGGLNKSTSRPYTKR
The following text describes a protein:
Function:
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Subcellular Localization:
Mitochondrion.
Sequence:
MSCHNCARRTLGLFIRSFANVEPTFAPKRTLIRNAQPSRLLHASTARAPYKSDQRDRAAPPTQKEADIEAIAENAENAEDDALPAKYERPAWQAHKAALKEKLNGEAWNPRKKLSPDTMEGIRHLHSTQPDKFTTPVLAQHFKVSPEAIRRILKSKWQPSDEEYEARMERWNKRGERIWTNLVEMGVKPPKKWREMGVGRARGGERPKWKSDRRNLVHVRDSASDSFVMDDGDIIPIVDGTGKARRAPDIPLTRRL
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGQDEVDGKHGKAKQHDPDFKGPIANRGCTDIICCLLFTAYVLGLFVLGVFAFINGNPSRLIYPTDSYGNLCGSGNMADKPYLLFFNIMECTKASGVFQFQCPTQQICVKSCPTTNMDGIRSPANETVCVYHVTASSPSSTDRTNQVRDGVCAPFYLKSTSQVRRCIPDVIQNSTSAVVDSTTGQTLKTPTGDPFSLSDIINGESGVAKFLNARVIGTAVVSDINNTWYLILGAVGVAMACSLVYILIMRWIAGPMVWLSMLGLVATLSYSGYYCFNQYSILNASNSSISFSFTTSIKEYGQMKETWLAGGITSAVVGGIILLILIFLRDRVSIAIELIEEASQAVRAMCSTIFFPLFSFLLQLATIACFLLSAGTKLYEVTLVPTSANSNYTAASVCNPADIPSAPLLGSLWRCFRYHIGSLAFGALIIAIVQLIRIIIEFLEKQLRAGPHDKANPIREFFFKVAIVDNVTAFLLFLGKLLIVGITGKFFSLDVILKGIASFYYFRNRSDLNYYLVPVIIIIICAYVIASVFFGVYDMAVDTLFLCFLEDLERNDGSTEKPYFMSKDLKRIVHKENEKPKDEADNKAEMAEVA
The following text describes a protein:
Function:
Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, perinuclear region.
Sequence:
MFRTSVFDKSLENATSNLNLEPDWQAILVICDTIRQGDVNAKYAVGALKKKMQSPNPITAMYALLTLESIVKNCGTPVHDEIANKANCELFQNLVNTTKHEEVRAKMLELIQAWAYAFRSTIKYRSIKDTMNILKTEGHKFPELKEADAMFSSDIAPDWVDGDVCHRCRSQFTFTVRKHHCRNCGQVFCAQCSSKNSTLPKFGIEKEVRVCDGCYAQLQRPAGTLVKKPTEEEDLPAEYLSSSLAQQAQGPARKTDEELREEEELQLALALSQSEAETKQQAQARRSATFHSKAPESPEPQTPQAQVKRSPSPAEEPPADPELARYLNRNYWEQRQVMESPASPSAPSPMPSPMPSLQPSLLMTKSAPEDAEIDEFSNMMKTQVEIFVNRMKSNSSRGRSISCDSAVQTLFMNVTSLHGRLLTFIKDMDDKRMWYEQLQDKLTQIKDSRAALDVLRQEHQEKLQRIAEEQERQRQLQMAQKLEIMRKKKQEYLQYQRQVALQRIQEQEREMQMRQEQQKAQYRMGTAFPFMGPGPAPGPQGSPVHVGGYPAPGYGPYGPMPPTNGTMPQYQPQPQQQQQQQPQPPQQMFSPQHAGQYVGMPGATAPGVDGQVPMQQGPMQAPPPGQPGIIPPGMNVMPGQVPPPGGMNMPPGHMPGAPMMGPPQQPQQQPPQQPQQQLPPPPPPGHPTGLMGGNPMQPPNAADMQQQQQQQQPGQLPPQVTMQMPPAPMAPGPDTAPVTAAPPPPAAVAPPAPQQAQPVAPKLEPETAELISFD