lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Involved in processing of minicircle Okazaki fragments.
Subcellular Localization:
Mitochondrion. Note=Enriched in the antipodal sites flanking the kDNA disk.
Sequence:
MLSRLSAVWRPSRVALRIQRVDFTTCGNRLNRSTQPNEPPLVSGIAARSRTAKAEPVEKRGRAAIKIDSPPPPLEPPRISEEHMTRRRKVGGGKTKAAAVTKSKQRRSGRTVGASAFNTARRANGIEGSAPGKGGASDVAIDDDDDEKLVDEESKQLMQLLKEEALRREEEKKKRLRAKAAAEPTEVTDDKEYLSKLGVAERTQPVGTEAKISAQGKAEGASEGQTHFSDADADSQLPILTSLSPEQQRALRLALKGRNLFITGGAGSGKSLLIREIVYQLRHNKRRCVYVTATTGVAALNVRGSTVNSFAGVKFGDGDARQLLKWVRRSRRAAGRWRYCQTLIIDEISMMDPLLLDKLDVIARAIRRRNEPFGGIQVILCGDFLQLPPIPPRNKPQQKTEENAEAQEGGDPTDGTPAPSKLQYCFETSTWTSLNLITVILHKKFRQHDDLAFQQVLDELRVGSLSPESYELLLSRTVASKSSAKSRKKKDEDAGNDGVLPLTDAETTPAAAEKDRHVRLCATNKEVEMRNAKYFAALEPKGLPIYPSPNDGSSQQTGSSNGANSVTEEDTMRPLQVYRAYDAYSTHETEPETTEETTTGTQPSQPWVRFEDSTLPTDLALKVGTRVMVLQNISLRLGLVNGSVGEVVGFLHPLELVELVLRAPRERHFPSARGQELLERAGLPTLQDAFRCVDTALGQSLFYYLRERGIRRPEDASYGCVYGNTHCRDILRLVGLGKTESANAVHPLEMYLGGIAPQHVRLTRLPIVRLDLREGNHTSSDSGAVEDGGFANGSKRLPKHVYAFISPSSHQWYMGDQPVATRTQLPLRQAWAMTVHKAQGLTISHVEVAIHRFFSPGQAYVALSRSTRLDNIRLLDFNNASVHACPRAKEFYTVLEEEELDNEIEDDGTEGDEEALEGDGEYEGEVEE
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAWGLDTTPTPARTPAAAAAPAPAAPVSSPTVAVLGPVPESAEAIDIYEGVTPVTSVALDGVALLQIIKHCHDSIPGGVAGSLLGVDSEQVLEVTNSFPSPPSSERKKGADEYQLDMMKGLREVGMDNNKVGWYQSVTMGTFCTASFIEHQFQYQKSLGPNAICLIYDSAETSKGSLSLRAVRLTKAFMDTYKSSSFSKESFAKADIRSATVVEELPVEIRNSDLITCWLQQTAHANDSAAASSFERLDLATNAYLESSLKNMTLWADELAQEHYKFQGYERALSKQRAAYQQWQNRQREENKVRRENGEEPVPEEDPSFFKSVNQPSRLESLLITKQMNTYCEHINRYAGKSFQKLFLAAKIHQKE
The following text describes a protein:
Function:
Promotes histone methylation by localizing the arginine methyltransferase PRMT5 to chromatin.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Localizes to promoter regions of PRMT5 target genes.
Sequence:
MADRRRRLRPGTLAPVREGVNCRSRCFTKHKNGLKFPTSLHSRQLVFPRKGLDDFRKGCPPCTGLVTQVPVEGFLPQIYHRAPQLAPKKRQIKLLKEADVLSKLSPAQQARKAFLEDVEAHLTPHPLALYLNLEEAMPIELLSKVLEVLDPDRKLEDTWAYCQDTRKGMKEPTKLLKKHSTQVYLGPSKKTSVSNAGQWLYEEKPHKMDLLHENGPRPGLHENGISDIDEEFILKQFDIDYETKPSHDALHTMKLNQVPLELKRSVGLSKLQETEFFQKLGYERKLQKPQNPYKPKWVKMRYGAWYLNPKLWKKQRVDEPLVDPEVSHKAQEENFKKELQEQEELLADLHGTVAFKDFILSRGYRTPRFLENMYIGKECKRACNKTPIKRTQA
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
MRHMSNDRANTPDQHSESQEPPQKTKKQPLLAFGLWRADNQERYERIYPNRLPFEIVTKMKNEWRHQTSAKIKESYYAKEQELRRQRENGSLQAEQHRIEVSRREAEVVQRVFGTAQREVESPKRDEYVKRPLNPFMIFCKNRRAELAISEPGLHCSEICKRLGAEWANMSADKKKPFYDEAGKLKQQVNEEFHLHPNYKFHPRKRTATQMSEGTSSSFGLPDSQLSSPMRQRSFNMTSQPSTSSYASSNFHPPTPMPRDHSNMVPQPISAPRAPSTIPTNNAPRAQQDISISPRIEYPRTSGRPIRRGQENYGVRDLPVWF
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Domain:
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Sequence:
MIDYKINEILVKQLNDDYNCSICVDPVLNSLPLEQHQALSCKNGHLLCQACWGKQLALRKECCICKIKVESISELCRNIFLEKGFRNKKVHCPNGFENFKVDEKLIKDESDGCKSVITIDQLESHLRECEFVFIECPNDPIRCKDKFRKNQTDKHMNKCQYVTINCEHCKEPVIKNDMPTHIENDCSIISLECEFCKDKFGRRSLENHIANECPNVVIDCPHKEGGCTARIKRCYLSQHLTEEDNHIRYMQKIIEKHRIQVEESDRIIKKLRVDYKELEKRVEITSRYKGNWTIENWSQKLTHYPNNERLKSPYFCIGSKSFYVGLYPNGFNQTNAGFMSIFLHLYEKPSTSTTVVRFSFELLHSDPTKSLKFEKSNKYTENKGSGFSQFIDIKMINNFIIDGKLTINIDVEVIPPSSSLVTK
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MAFLLSAWLPTFRTYFSLFSTIVWQVMEGMLLDAVSKSMVAEGAKLVPKYGVRNSALMSLSVNALKGNPTYDKARTLGNRELSRLFPRGFSIAVVEHIVASSNQTAHLRLEECFSKYAILSTVAKNSDTYQLGCYKPPGVREVVSEAMDSKFSALLPYCEHWAEAVALECLPSNTPFAAKLALEFIDTTCYYAERMRSLGSVVEAGNILLQSRISDPFAAEPHSIGVSGGVKKGEKNDAFWQKFATTVPLSSGPHASHGMLGYEWYILRMKVGAILSLGMLSFMGEKSRSRLETKSMVRSIICGIL
The following text describes a protein:
Function:
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
DQRETSVKISVNLNLVADSMLRTRPLQLVPLALLVALQRCLAARPLLVFLIDGFRYDYLDDLQALPGFRALVERGVKVDYMTPDFPSLSYPNYYTLMTGRHCNSHQMTGNYMWDQSSQKEFLIGTNDDSRLPLWWDGSEPLWVTLQKLGKKVFMYYWPGCEVEILGVRPAFCKEYIYNPTEENLSESITQALDVLRSGRADMAAVYYEKVDVEGHHFGPDSQQIRSTVQQLDVVMQMFNRKMKELNMEEQLNVLLFSDHGMTKIQWMEKVIELDKFIAMEDILKMMDRGAVVSLWPKNSKYQEVHAALSRVPNMRVYGQQEVPERFHYRGGRFVSPLTLVADPGWFISENKAKLPFWKNGSESSGWQNGWHGYDNELVDMRGFFLAAGPDFKQHVQAAPIRAVDVYNLMCWTLGVKPLPNNGSWSRVEDLLRSSGGPVERGSCWTCCIGLLGSLFMFWE
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial mia40-erv1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MSPITLDLTSDFNPANTTGAGSSSSQPRTLLVAPPSVASHEERISALFSTYPRDTTDLHMLDRLAAGLVTLPTSTYDLILVLTDPDGSRHAEASALLSNRAVWSLLVPALKAGGKLRSEDGTLGRDTTTPEAREAVLAGLVAGADGFTKPDYAEEEAVPLRFGLKRKTNPNPVVAPIQPVAQVVTAAPAGVGFVTLDLNDDLDLDGEDDDDDVIDEDTLLTEADLRRPIQQPPECQPKPGKKRRACKDCTCGLAERLEAEDKARRDKADQALNTLKLKSEDLLELDLTVPGKTGSCGSCALGDAFRCAGCPYLGLPPFKVGEEVSILNNVPQL
The following text describes a protein:
Function:
Required for nicotinamide riboside transport across the inner membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEMNYLEIFGTFIGIIYLWLEYRASIYLWLAGIIMPAIYIFVYYDAGLYADFGINIYYLIAAIYGWFFWMWGHGEKKSLPIIHTPWKCYLPLFLVFIVSFVGIARILIEYTDSNVPWLDSFTTALSIVGMWMLARKYIEQWFAWILVDIVCCGLYIYKDLYFTSALYGLYSIIAIFGYFKWKKIMNMQ
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSANYWASTQCNNWLLDRPQLELARKEDLRYATRLECAALGVFFSNLLSLICKRLNLRQRVTASANVFFRRFFAKNSYSALDPFLVCATCVYVAAKVEESPIHIKSAVAEATRSFTEHGFRGMPTDHSSLAEMEFYLLEEMEFDMVLFHSYRSLIVMFEDYGSGSAVGSGNSIHERSAGAAGSGSGSGGSGMMIGLGIEAAAFGVTKGLASVEEGDAASAIAEEDKVQLNEFNDEVLLMCWFILNDTYKTDIPLMYPPYMVALASIWLGLSLHPPSFDKITASLHTMQTRRDEHHLSIQRILDNPASTPAELASAKREPSPPSQDALTFFASLNVSLPLLAEIVQEMVSAYSVQHQVQRLVSDGPGIVKLLERMRESRRVALIKDRDQTRTHA
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAEAAFHPPRRKRRVFECYQAPFPVGPGAGDFRMCRADMVNNCVVVRSPEDMDQLYNKGYFGKGILSRSRPVYSISDPSLVSKWQGANLNVPIITSKKYQQRVQWAKSALQEQGFDGCSVTKILENYTRPLEFPFLEKGGAEQTGDSCDTVCPNTENTELSGQSSTDTGNIATSSPECQKEVCQKAYAEGDPASDSMVGSKEQEPADVKETAQTSCQMHGSCMHCGCKAKGAPDRESCNMAKSRERAPEYVLVQEEEESSLCPEEGSAREQENFVKKEKLVCRRNPFRIFEYLQLSLEEAFFLVYALGCLTVYYGEEPLTILKLWEIFSEVKPSFKTTYMAYHYFRSKGWVPKVGLKYGTDLLLYRKGPPFYHASYSVIAELVDDNFEGSLRRPLSWMSLSGLNRTTVNASKELLLCYLIKPSDMTEEEMATPECLKRIKVQELIVTRWVSSRERSEQDDL
The following text describes a protein:
Function:
May be a desaturase involved in mycobacterial fatty acid biosynthesis.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MAQKPVADALTLELEPVVEANMTRHLDTEDIWFAHDYVPFDQGENFAFLGGRDWDPSQSTLPRTITDACEILLILKDNLAGHHRELVEHFILEDWWGRWLGRWTAEEHLHAIALREYLVVTREVDPVANEDVRVQHVMKGYRAEKYTQVETLVYMAFYERCGAVFCRNLAAQIEEPILAGLIDRIARDEVRHEEFFANLVTHCLDYTRDETIAAIAARAADLDVLGADIEAYRDKLQNVADAGIFGKPQLRQLISDRITAWGLAGEPSLKQFVTG
The following text describes a protein:
Function:
Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin. Is not involved in the regulation of trichome branching. Is functionally equivalent to ZFP8.
Subcellular Localization:
Nucleus.
Sequence:
MKTYDFMNVNSFSPKERPIRLFGFEFGASHEESESKDNYNENNESIKDDNKEKRFKCHYCFRNFPTSQALGGHQNAHKRERQQTKRFNLHSNAAAFFHRQQNHIAASRLYEDRYSLEAVQINDARLGLCRMYNSSASFNRDRSSYYNRYIPWFIGDHQTRPTYVGGGSSSHGLFYESKKNVPDHVSLDLRL
The following text describes a protein:
Function:
Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNFFEHSPAQSPATTNSSVTNPIHRQSSSSSLHMMGYRNQGTAGPTSATGATTPTHGPTTHAPVPMVPVGLDLGGTTSAPAASATGGLQSNRQSPSPLKRAQSRHFDIDTNNPANSASKRSSFSSTTSASSVWPGTSATATDASRTTTPYYNLTQGMAGLGLGGPIGVAMGSGVPSPHPGMGSSPSVVPGMAPIAPTPVAPTAVHPGLADDDLIPTAIVIKNIPFAIKKEQLLDVMTQLRLPLPYAFNYHFDNGVFRGLAFANFTTADETAAVIGSLNGREIGGRKLRVEYKKMLPLAERERIERDKRERRGQLEEQHRGQGGQGGGRRNVSGGHTQQHGGAQPPQQQQQQQQQQQQSNLTQSGSVGQPAHTLPSHVTPHMSYPQYSPSPTPTPPPAPKLDLNDPETLEFYSQLLLFRDDAKRTEIVYSHPLLLPQQRQIVMSLCDQLGLIFNSEATGLVVVTRQRQYYEYQY
The following text describes a protein:
Function:
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Subcellular Localization:
Cytoplasm.
Sequence:
MHGVYPILVVPCRRGGIPYLTPEQARDILGEEERILSLSIFDAYEYKDACKKAGKSFAEFCGLGEFRVILTVRSPYVGAHASVSASETAVFGVHEKGRISFSNESWAEIVKSVMPNMAITLYDSVPLHEQHSKRRKTASTRSLKWAKSAECAPDIGCELIKASSVADRENVFVCADELGQNETIVQYASRLCEITKNHYVMSPTPSLGAVLMALKVGASFIECALPWTLAERGIALVFDMNPVHGCSPQRYESQIDLNDHCFAVDINPLSQACVCSTCRRHTRAYVHHLLTVQEMNSCILLVVHNLAFLVQLIGLYRRSTAEARESLLTWVLAQL
The following text describes a protein:
Function:
DNA-binding protein that plays a critical role in nucleoid compaction, genome replication and DNA replication and transcription. Binds to both ssDNA and dsDNA with a binding site covering about 15 nucleotides. Displays DNA-supercoiling activity only when associated with the viral DNA topoisomerase 2.
Subcellular Localization:
Virion.
Sequence:
MAIKKKTSSRKKSISRKTGKSKTRVAAVKERMTKSQILAHLAESTELTKKQVTMIFEALSDLTHAHLKKGGAGEFVVPGLCKCSVKRKPATKARKGINPFTGESMTFKAKPARNVVKIRPLKRLKEMVE
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MRRARPRQDNVKPKERKASGAVHPRSLHPCPECEKKFTRNFQLKLHMTAVHGMGEMRYQCEECRKNFASRHSLRYHVKSVHSTERPFGCQHCDRRFILRTQLLSHLRTHTGEAKPRIFECQRCSKSWPTKSDLRTHMRSHNPNMERPFKCDRCSKAFFTRGHLNSHLLVHTGEKPFACEYCDKCYQSVGNLNNHMVRLHADIIEAQLEAEGIES
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MNSLQKLLEWLANLVELLGMAWPFLLQGAMYTVLFAAVSMVLGLILGFSVAVVRVTKVPVVSQIAAVYVSAFRGTPLLVQIFVLYYGLPSVGIEFTPVTAGILALTLNVAAYLSESMRGAILGIDKGQWEAGLSVGLTWGQTLWNIITPQALRLAVPSLSNSLISLIKDTSLISVITVTELMLATKEVIAETFQPLPLYLAAAGIYWLLSALFERVQKALENRLTAPLRR
The following text describes a protein:
Function:
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
Miscellaneous:
MISCELLANEOUS: Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.
Subcellular Localization:
Secreted.
Domain:
The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.
Sequence:
MTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFLLPDDGKMQHLEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAVTVLQMVPMSMPPILRFDHPFLFIIFEEHTQSPIFLGKVVDPTHK
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MTAGAGARTVAARMMGNALPGGGPEDSSGSATVTHGGAVCRGGPSDEEDQTSSEEEVEENGAKWGVPLAVDLTPEELARRRAAQMKRLLKLYRLQYWGLIEEMRSKHRRYFLRQGTSGWKEEGEGAATEGTMRPVCSKAGCTDRAMPASSFCFQHILCDPRQQLYCACIHSPSPDEPCPRPVLRAVVPALCAQHAALRKTSQSPRQRPSSAGSSAGGATSSSSMLPVPPVHVLMNEYIRVLQRHRTVTAALKQEVKT
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MANRTVADAKNIKGTNPQYLVEKIIRTRIYESKYWKEQCFALTAELLVDKAMELDHIGGTFGGNIKPTPFLCLLLKMLQIQPEKEIIVEFIKNDDYKYVRALGAMYMRLVGTALDCYNYLEPLFNDYRKLKRMSQTGVYEVVHMDEFIDDLLREDRVNDIILPRIQARHILEATNTLEPRRSLLEDDLEDMESEEEEEEE
The following text describes a protein:
Function:
Component of a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSTNKNHNNNTNNNDNNICINPHIVEFLNKQITNIKNRPGADIKTTSIYKKAIRSLNLYPLPVFSGKECEVLNGFGPSLTKKINDYLKTTSHPLYPKGPPTPLKSIYNRNNNNNDNNNNNNNNNNNNNNNNNNNNNNNNNNSPKKKIRKSKNNNTTSTISNTQSNLIGTESPSKNQNKQLERELKSKKKKQQSAILEQIVEEEDINFEIPTNENYYDYGSGSCFDNNDDNDDGYISSGINTTPDDLNKSFNFDFGSFDNGIPNYNNNNDNGGDNENNINSDIDSNKIKTTTSINDNHKEKYQKNNENYIHENEDNGDDVIVLISPIKTYKYGDMLNKSPSKFKSPSKLRSHNTTNTFNNSNFSNSDNDNNNNIRITTPLKNQNFNKFNDSIIFSPSISSPSPSKLSNYHKYLNNNNNNIKNTPISTSKKRKCNFSSPLLFSPFKYGVTSPFSPSKMKLKSPFKKRFKNDKSPSSSISKNKNSKSNDIVNNDFEDDDEVVNIQSESEINNNNNQFTSHNDNYNYSYNYNNNSNNINNNNNNDDDDDFDLTETEDEKDDYDKDDRTFSNLSVRLSFTEEDLAGVNIGESIINNSKLPKVIPSQIPPPTQSTQSTSTSTSTSKSKSKSTIKIKFKNIKCIIDNREVKSVTERDYICNKLNERGINAQVKKLELGDFVWVAIDEHDNEWLLNYIIERKRVDDLSSSIIDGRYKEQKFRLSKSGCDNIIYLIEGIVSNTINSSSQSQKKTWGTVNFSLSPDALATALVTTSICEGIIIKETKTIDNTIDYIVNITEYFKEKLLKNNNSGGGGGDEIIKFLFANKNTQCTLENFNQLNSKSKGLKLIEFFATQLIQIPGCSAEKAHSITQVYPTPMSLYLALKAIKDKESGESHFKDFTFGKNKRRFGQDVSEVIYNLYTNKKYLN
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKFLSKFQKTWFCQWRPGSLDILIEAGRLTRHECKRQFASRRWNCPTFPDEKNGGSYNKIKINNFPGNKETAFLQTLTSSSMAYVITKGCASGAIFNCGCDTDRRDFYTTNNYLNNNYNYNNNYNHNHNNEDDVIFKWGGCSDDVIHGIEFTKNLIDESSDKIIRIGESRINPDKINAKKAMLQHNVNTGRDVLLNSIIVKCKCHGISGSCQTKTCWRTLSQFQSIAAEIMTRYDHAEKIERGVRKNIARVVARDQKNNNNNTNNLVYVINSPTYCTPLPKFDFYGTTGRTCDRKSGSQYGSCDVTCCGRGYVTVVRRVTERCNCQFHYCCTVTCEKCERSYDEHLCK
The following text describes a protein:
Function:
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
Sequence:
MAGASEALERGCWASMAPGSVPGVGGGCGKAESPGPGTPCFDLRSQQPRPHCHCRPAVPAMAGSFNVPHKTSLPEGIRVGTVLRIRGLVPDKAGRFYVNLLCGEEPGSDAALHFNPRLDESTVVFNTLERGTWGAEERGSGIPFQRGQPFDVLLIATEEGFKAVIADSEYHHFRYRIPPGRVRALEVGGDLQLELVKIF
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLARKRRSITGKSAVKHTPAIKPSKARKVIRRYHVLLQKRRAICKLLGIPVAENDEVLNERQIARYVTDAGLQEQYRLGADMAHPDEKVERELLKIQKMRESPLLVQMLGYVMAEINGPRGLQNYQAASTVGQTASRGGDTSRQLVPWLREAGTPADARALEIGALSAANCISTCGLLRTVVRIDLHSNDSTAIEEQDFMLRPLPQADADAFDLISCSLVLNFVPTPLARGEMLLRFRSFLRGPRPLLFIVLPLPCMENSRYMNSEYFCNMMTALGYNCLYQRSAKKLIYFLFASRTGMPAPYPLKYTRKHQLADGPAMNNFSITLPALSSPRI
The following text describes a protein:
Function:
Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAKDSPSPLGASPKKPGWSSPAAAVLENQRRELKKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADHLRSKWEAQRSQELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHQERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSRGSCHAPKPACQLGSPDSLSAEVGVRSRSLDLVSSACSSSPDGLLSTHTSSLDCLAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPQGGEGSESQPCEVLTPSPPGLGHQELIKLDWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTELARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGQEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHASWKEIQAPQCRPGHPPEQPWETSQMLESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSEKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSMSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVQQIPDSYIPGCLPAKSPDLGPNQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEILDTKMEACQLGLLQSMGKQGLSRPLLGTKGVLCMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGMHYRARVEVRLPWDLLQVYWGTMSSTVTFDTLLAGPPHPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLALAPLSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQDHRPPSVSEQPGEKENCYQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLQQKQDAQGFTPPQLGASQQYASDFHNILKEEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGTNTPARVFVALSDYNPLVMSAILKAAEEELVFQKRQLLRVWGSQDTHDFYLSACNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSTLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHGGLVPAHLLDHMSLHGH
The following text describes a protein:
Function:
Essential for the invasion of host erythrocytes by blood stage merozoites. By binding P113 at the surface of the merozoite and human BSG/basigin on the erythrocyte membrane, leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes. In addition, the interaction with BSG results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte. This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, rhoptry lumen. Host cell membrane. Note=In late schizonts, localizes in the rhoptry lumen. During merozoite invasion of host erythrocytes, secreted at the merozoite apical surface where it colocalizes with CyPRA and RIPR at the interface between the merozoite and the erythrocyte.
Sequence:
MIRIKKKLILTIIYIHLFILNRLSFENAIKKTKNQENNLTLLPIKSTEEEKDDIKNGKDIKKEIDNDKENIKTNNAKDHSTYIKSYLNTNVNDGLKYLFIPSHNSFIKKYSVFNQINDGMLLNEKNDVKNNEDYKNVDYKNVNFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINETYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNDDSYRYDISEEIDDKSEETDDETEEVEDSIQDTDSNHTPSNKKKNDLMNRTFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIYVLQMKFNDVPIKMEYFQTYKKNKPLTQ