lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MALLVRLAAALALLLLLPPAALAFNERAEDLLDLQQGSRDGVIHFKEDSFDRYVRGSEPRGYSLVLFYAAKQVADKPELGMPALRKDFGLVAQSYQKTHKGTPEELLVFFADVEFSESPNVFADTGVNAVPHIRRFPSVGDGSAGEDTFDLNSFPRTAEGIASFVEARTKLKVGEIVRPPPLSKLQVSLILAAVLLLGPYIGYKVLSLPAVQEPKLWAIAAIGVYYFSVSGGMYNIIRGIPWATADERGKPVFFHQGQGYQLGGEGFYAGLFYLVTSLLLFIMTYVVPRLKSKSSQRIWSAICLFLGFWVVTQFVALYKWKSGYYVHGYWPRRR
The following text describes a protein:
Function:
Amino acid transporter which has pH-dependent electrogenic transport activity for alanine, glycine and proline. Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway. Required in enterocytes for the efficient recovery of gut epithelium following the cytoplasmic purge response to bacterial infection. Acts cell-autonomously to promote the retrograde transport of amino acids into the intestinal epithelium. Acts non-cell-autonomously through the insulin signaling pathway to stimulate Myc expression and the release of amino acids from nutrient stores into the hemolymph.
Miscellaneous:
MISCELLANEOUS: 'Arcus' Is the Roman goddess, homologous to the Greek Iris, who personifies the rainbow and replenishes rain clouds.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Note=Partially colocalizes with the late endosomal and lysosomal marker Lamp1. Localizes to the basal labyrinth in enterocytes of the midgut.
Sequence:
MNDDIKTVTVYPTTLELTTPTKSANGSNDDYDPHQHRELKNPTTNFQTFAHFLKASVGTGVLAMPSAFAHAGYVNGTLLTLIIGSLALYCLHILIKCMYILCKRQRVPYVSFSQAMNLGLKQGPPWLRCLAPIAVPFVDGFLAFYHFGICCVYVVFIAESIKQLVDEYLVVWDVRIHMCIIIVPLLLIYSIKNLKLLAPFSSAANLLLLVGFGIILYYIFEELPPLSERDPFVAAGKLPTFFGTVLFALEAVGVILAIEENMATPKSFVGPCGILNSGMSIVLGLYVLLGFFGYWKYGNESEGSITLNIPQSEIPAQVVKVFFAITTWISYALQGYVTAHILWDKYLAKRFKETRQTFYELIFRAIIVLLTFGCAVAIPDLSVFLSLVGSFCLSILGLIFPVLLQICVQYTEGYGPFRIKLIINLLLLCFGIFGGVVGTYVSILDIIAVYK
The following text describes a protein:
Function:
Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Note=Associates with rDNA transcription unit throughout the cell cycle.
Sequence:
MRPLTMSGHFLLAPIPESSSDYLLPKDIKLAVLGASCVGKSAMIVRFLTKRFIGDYEPNTGKLYSRLVYVEGDQLSLQIQDTPGGIQAQDSLGQMVDSLSKCVQWAEGFLLVYSITDYESYQSIRPLYQHIRKVHPDGKAPVVIVGNKGDLLHARQVQTHEGLQLANELGSLFLEISTSENYEDVCDVFQHLCKEVSKLHSLSGERRRASIIPRPRSPNMQDLKRRFRQALSSKAKAASTLG
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSSKLKSLDEMIEIEYENEMNKQKVDCKKPKFTKNESTDSWMDMPANTLKHKKDINDQKGDLAKQAYSAYERKIRWLNPKDTEKEYQQYKQNDQLRQKIQSGYVSPEKIDCLQKQLARGKKEAQRFHRERKEKSFQRDYINVNNKKFNEHVNQAYDQYTSDIKDALEH
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFFDLSRTVRMARLQKIYACLRYLMLFVNGIICTGGFVLLGLGLWIKFGAASFVQVMGSFSAQLINIGYICIGVGAVLALIGFLGCCGAWKENRCLLLLFFAIVTLIFVAEVVGAILVLVYRAVVEALVRDTSKKSLMQGYMGPAASDTVSQAWNTIMIGFKCCGFDNYTDFAGSVFSVNTGLSYPKSCCAVLTEPACNGLDMNKTLIHQKGCFRVLISLVQEKSVIIGSTAAGICVLELVAMIVSVVLFVKLGIQNNVW
The following text describes a protein:
Function:
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular Localization:
Cytoplasm.
Sequence:
MHFDDLPVLPTTPGVYIFRKGGVPIYIGKANNLRSRVSQHFKAGGKSGKFTKLAESLEFISAANEVEALVLEANLIKQHRPHYNVLLKDDKHYPFLKLTNEAYPMLVVTRRVLKDGANYYGPYPDASAVRRVKHLIDTMFPLRKNSGLPMQKKPRPCLNYHMGRCLGPCIDAAQPDEYRQAVEDVKALLEGRAAPVIARLKEDMKVAAQGQDFEQAARLRDRVQAVEKLFGTEQHAFVSEETDLDFLGAAQAGEFAMVQLFRMRGGRVVGRDKRFLTGADETGLGEIIGAFVADYYTQATHVPPLILLPAEYEDAALWSEFLSRQAGRRVEMRTPKRGDKTDLIEMAQRNAAVGLDSEMALLERRGDHPGLDALKDVLALPERPWRIEGYDNSNLFGTNIVSGMVVFEGGRSRRGEHRRFKVRGLEHPDDYESMKQTIYRRFTGSLADKLPLPDLMLIDGGRGQVNAALDALKEAGVQVPVVGLAKREERLILPGRYGAQWWLETGTEVGVDRELLLPHTHPALRMLIGVRDEVHNYAVSYHRKLRGEGMLRSVFDDLPGIGQKRRDALLEHFTSLEDLAAAPVEHIAAVPGMTLRAAQSVKEFLQAREAQLPRAGG
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSSEALNSPPATSALSSESSSNVRSLKPVIKNVDMSEDMQSETIEIAYDALEKFSVEKDMAGHVKRTMDQKFGPTWHAVVGQRYGSYVTHETKHFIYFYLGQMAFLLWRA
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.
Subcellular Localization:
Nucleus.
Sequence:
MCDFFWLSPADQAGDLSDVVRASLQPPPPPPHHHRLPPPEEEEGLLLLQARVNFDGDDHDEARSQQLVHGNGSMRLMLGSNGSGGCACDHAAALCPQHHPEAERLIPQPPMSGPQPQLCAASSFVVERDDDDAPVLEEHVLDMATAPHPHPHTSAIKRRKSQTKKVVCIPAPVAAPPPGVGGRPSTSGEVVPSDLWAWRKYGQKPIKGSPYPRGYYRCSSSKGCSARKQVERSRTDPSMLVITYTSDHNHPWPTQRNALAGSTRPAFSSSSAARSHHHHHHHHHSAAAVPDTTLAHRHASNVAVADNATPGWSIISASVHHQLLKQEVVDVDNHPISKQPAQDAAADRDCLDMFADMDGALDVLCASNFHPKKQQQQVTAAQHLEKLPEEEDEHLLLGPDPFSFSFLDWVGASFGVGETAADNGDHS
The following text describes a protein:
Function:
Modulates chemotaxis responses by regulating positively the sensitivity to CO2 levels in BAG neurons and by regulating negatively the sensitivity to quinine in ASH sensory neurons.
Sequence:
MWRSYKAETPELADETQEVDLNLHDSSESDHEGRQSRSASITSSTSAPASNDVTLQVPITNSSATSPTPSTGSMYFIAGMFDGKEKVNREQPPMPTTDGVEYPRAASWAAGNCANVLNDDKGKQLFRVFLFQSLAEENLAFLEAMEKLKKMKISDEKVAYAKEILETYQGSINLSSSSMKSLRNAVASETLDMEEFAPAIKEVRRLLENDQFPRFRRSELYLEYLEELLPRSYAEKWAQSFEGLLGNHVGRHHFRIFLRSIHAEENLRFWEAVVEFRSSRHKANAMNNLGKVILSTYLAEGTTNEVFLPFGVRQVIERRIQDNQIDITLFDEAIKHVEQVLRNDPYVRFLQSSQYIDLLSKLK
The following text describes a protein:
Function:
Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2.
Subcellular Localization:
Secreted.
Sequence:
MDLQMIFSLLVVLVQGVSATESLSDSATLANQPPAPTVQTHSQRSSGAPWRPRRVKRCSCSSLMDKECVYFCHLDIIWINTPERTVPYGLGGPRMKRALQDTDQEKLLEPAGRCVCAKRKDKKCMDFCQATAEPSVQPSVAKDRRQVQQATKCLGLRLGQQCIQKQHHRNKVMKRSESIKQSIKNSFTFASLMKKHSETRETSHHWMHKNWGVWKHRKTTS
The following text describes a protein:
Function:
Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDTVFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAIRVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVTTYFAVE
The following text describes a protein:
Function:
Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MRIHCKVVAIAVCFGVFLLLYFFGGNAADEPPLKEVAKEKHFPSFGNFEDIVLLKGAKQTNEEPQKPPKLIRKEPKLSSRRAENVIAKTRLKSEVGRPRSKVTLAEDVMHLAVVACGNRLDETLNMVKSALLFSMKKIKFHIFAEEDLAEQFERGFSQWPQTLSSRFHYSIYPITFSVGNADEWKKLFKPCAAQRLFLPVILKDVDSLLYVDTDVLFLRPMDDIWKFLKAFNSTQLAAMAPEHEIPKIGWYSRFARHPYYGVTGVNSGVMLMNLTRIRNTLFRNSMIASGLSWENLLHPLYQKYKNHITWGDQDLLNIIFHYNPECLYIFPCQWNYRPDHCMYGSNCKAAEEEGVSILHGNRGVYHDDKQPAFRVVYDAIHEYPFEENLFQSLFYPLQTKFLDTVNTLCGRIPQVFLKQIEKSMKAAYEKKVVRRVRPPHK
The following text describes a protein:
Function:
MFS-type transporter; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids.
Miscellaneous:
MISCELLANEOUS: In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MQSSLLGRMTGVTGSRSKRHTKFRLRRLQQPPTESTTRLASPDDAQPIEETKSQEHLEQSATQGLSEASGDNNAGGAHPTPAPNEGDAPTVAELQHGSNDRVDDGTSGSGTVSGWKLAAVLIGLSLAVFCMSLDSTVLSTAIPKITAEFNSLHDMAWYVSAYNLTISSFSLVYGKIYSLYRVKWVYLTTLFLFEAGSLVCGAAPSSLALIIGRAIAGVGGAGVFLGSMLIVHEIMPLHQVPLFIALISGLYGIASVVGPLLGGVFTDYVSWRWCFYINLPIGGLTAFIIVLFVRPRVREKATVKKTPWAQLLDLDPLGIILILPAVMCMLLVLQWGGAKYAWSNWRIIVLLVMAGSLALTFTAVQLWQGERATIPPRIVRNRSVWGAIAFSVCIYGSFTVFTYYLPIWFQAIKSVSATRSGVMNLPMILGVVVCSMLSGWGVSRVGYYVPFMYMAPVVGSIGAGLLTTLHVFSGPAAWITYQLLLGVGIGSGMALPLVAVQTALPTDDVSTGSAIITFTQSLSGALFNFVAQSVFQSRLVHNLNAALPGVDTARVADVSPREIRNAIEPEYLPQTLEAYSLAITQVFYAGTALCTLALFGVLPIKCLSVKGSRIPPMAHA
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH); Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Hydrolyzes phospholipids as well as galactolipids. May play a role in disease resistance.
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MAPAAAATKQDGELRILCIDGGGIRGLIPAKILEYLEAELQRIEGSSTARLADYFDYIVGTSTGALVTTMLAAPDKDNRPLCTAKEIIDLYLEEGAGIFTNEHKATWAQVVLEAVLLYIKYYDGDNKTLRSLHDMLAVGLAIEPLLRPILDALIHANGGGLQQLAAAPHDPDDAASNGDEAPPANMEDCIQEHAGAILQAMCRAQGLALDSTPFDECIKEFVEGLRMTLLNPDFVRYALLRPKYDGEGLRKVVRGKLGDRKLKETVTNVIVPTFDIKRNQPVVFSTSKAQQDRVMNPNLSDICIAATAAPTFFPAHKFYIINLCPLNFELEEFNLIDAGMFANNPTTVAMNEVWRMIDRGEHLPVEGLSPMDCSKLRILSVGTGVVNHSYTADECNWWGVLPWMYNVRNKTQPLVDTLMYATGSLVDYNVALLFKSQGYEDHYLRIQEDHLDPSLGAMDDTSSMEKLIETGENLLDRQVYRTDCETREYRPVKGAGTNKEALTKLAEQLVAERRRREATAPPMLLMSVTEIATVVEPRPKRLKPTYVVQ
The following text describes a protein:
Function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Sequence:
MRRLLRFCTSRNISNILKFIQPSVASRVHSPSLFTSFFCRTFSDSGTSMDLSNMRKTYKSDQECFEENQLASLDPIKQFGSWFDQATKCPEVGEANAMCLATATKDGHPSARMVLLKGYSEEGFCFFSNYESRKGSELESNPHACLVFYWEPLNRQIRIEGTVERIPYEKSREYFHSRPKSSQIGAVVSRQSTVIPSRQYLRDKNAELEEKFKDTDVPMPDYWGGYIVKPSLIEFWQGQTNRLHDRIVFLRPKGGETELGDMQHQAEGGWIYQRLSP
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDETILSKQNNYPGCYIKQDLKEADEEHRNHKELKDKKYGFYFLLFQGLVYTITIISFGFGNPDQLGKPYDSDQKVCGVDVGLEQYKFIYFTNPSDQKHLGRTVCVKECPVLEEDHNEDESLALQCYPNNAINSCRNRPSIDDPNYSMIYYDSVPFIDVCLPRKSNYFHNIQHGLDQSEIISFLSDMSSGRAIILASLALCLLLNQLFYFMMIKLQKTSIWVISITSIFALFISGVLGLFYYLKQYQYSEQEITTAKITKEQAIGMIQVQESNITIILISSAFFLLCGVYFLIDLIVNRKRYKTMGVKISIVNYFFDFSSSGIRQQEGQTSRFREMLILLMGSAGCLLVFCALWIWMATNLFSIGKAVQGYYPFNTYQLNWTTYLMGFIHIFELVVVTLAILGSEQMLLIGKVVEVYKHMGIQRLKIDSQDPEQSLMDILEIYAFNNFGSVVFGEVIIFLLMIPRLFIKIYVWISLKYDAEFEIPSFFQQILCINDRAYLLAYLRNDEFLLSAKSQYVFDKRLKETTDVQYHGEQLSVTYCFAVANLCVSLTYILIITTSTKIGIHQPVYFLLVSFIFSYFISMMFSTVYGATIDNLTILLYRDTTPDGQEVGTCVRNVVRLMKESELDGQTHQQQQQHEVQD
The following text describes a protein:
Function:
Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Sequence:
MKRSIIAAAVFSSFFMSAGVFAADVDTGTLTIKGNIAESPCKFEAGGDSVSINMPTVPTSVFEGKAKYSTYDDAVGVTSSMLKISCPKEVAGVKLSLITNDKITGNDKAIASSNDTVGYYLYLGDNSDVLDVSAPFNIESYKTAEGQYAIPFKAKYLKLTDNSVQSGDVLSSLVMRVAQD
The following text describes a protein:
Function:
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MRWVRALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLGTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNATNANQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
The following text describes a protein:
Function:
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Sequence:
MTAETHLQGVEISAAQFFEIWHHYDSDGNGFMDGKELQNFIQELQQARKKAGLDLTPEMKAFVDQYGKSTDGKIGIVELAQVLPTEENFLLFFRCQQLKSSEDFMQTWRKYDSDHSGFIDSEELKSFLKDLLQKANKQIEDSKLTEYTEIMLRMFDANNDGKLELTELARLLPVQENFLIKFQGVKMCAKEFNNAFEMYDQDGNGYIDENELDALLKDLCEKNKKTLPTLQHTRKASWPCLMEESFTEQNWLLFSVLRKTRALLSCPLN
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MGGNGKHRWKFSFHRSSSQTSNPDPNQVPKEFTCPISGSLMSDPVVVASGQTFERLAVQLCKDLNFSPKLDDGTRPDFSTIIPNLAIKTTILHWCDNSRTQPPLPPDYASLERHVREEKEKQDLIRVSEKELLNAVADNPPVIFSHAATELGPRVNHFNSGSSSEESVIIPPSPGTPLPLTIRPTCFSSSSSSCEIEIENPNTPASEEEEGILKKLKSNEVFEQEEGAIALRKITRCKEEARVSLCTPRVLLALRGLLASRYGVVQVNAVASLVNLSLEKQNKLKIVRSGFVPFLIDVLKGGLGESQEHAAGALFSLALDDDNKMAIGVLGALHPLMHALRAESERTRHDSALALYHLSLVQSNRLKLVKLGAVPTLLSMVVAGNLASRVLLILCNLAVCTEGRTAMLDANAVEILVGLLRGNELDSEANRENCVAALYALSHRSLRFKGLAKDARVVEVLKEIEQTGTERARERARKVLHMMRTVGDGDGDEIDEFYDSAGLTRNRYRVGAARNNNNLVNTTTF
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MIFGYINKLSILNVNPFSKASQSAKLLLAVASKETSNSLYGLNLITSLASKDTNSKPSVEVVYKDGKKLTVDPTKMNIGRLTELIDDYSKTLKFKEMMQK
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MEINNGAQPENAAVSIPSRSPSGKSEKRKSPSIVSGCRTVMNERSFTNYWSVERFTVQLELHNPAEFMLAPKFGDGDYEFVMKLFPNGKDEETAGYLSLFLLINKCPNPRLRFRVSFTVETADGPRSCHLNKNLVTINRSGIVTASKFFSLDILRSAMNVYIPNDILTIGCELTIFGECTTQISSLFKPYQRTHSASSTSRSLSSPNTKCLKIDESSAHDAFTEFLSTGEFSDFIIVASCGREFPTHMCILAARSEYFKVLLRNHSTKEFMSKRLQFDDISARTLDVLLRHMYASAAGRVVKLEEDQLTEDLISAMDRLMINSLRDEVARLIGSKVTVDNVLTRISMAAELRLDDTYDVLLDFFSNHKHECMKLTAWDELESAKPPLAIKILRDAFSNTDSPSTTSMDSRIIDRITLT
The following text describes a protein:
Function:
Membrane-anchored myosin receptors that define a distinct, plant-specific transport vesicle compartment.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein.
Domain:
The GTD-binding domain is sufficient for myosin binding. The transmembrane region (1-61) is sufficient for the membrane targeting.
Sequence:
MGSRSFTRALALAFNEWLLMFMLFVNSIFSYVIARFADYSELQSPCLMCSNLDHILRRTKDLKKTHWDIICSKHKSEISSLVYCHAHGKLVDVRGMCETCLFSFATTNKSNAETYRLLVGKLGEDSHFGSKSDRSKYPNCSKLTDCTCCNQLWTPQTAATQVAEREILPKIGLLGKIRTGKQSAPKKSVSFNHLPDVGYTELKIHSDTESEAVFSDTEPKQESSLNHLPPVGYNEPKIGLVGDVRTGKPSTPKKSVSFNHLPDVGYTELKIHSDTESEAVFSEDECVVLKDEDHKYQIVDLQTHPIITLPYDLATDKLLNFDFPLEPFVTRNDREEVQLQETNWRTYSSFPVLIPVNDVPETSEKVFKEEEINSLDNLFLTSRAMKHFAAAKVKEEPIRLQDISSTPDVKENPANASLMEETELICLSDVTATSGAMEHSEVILKEREELIHLQDISVTPDFKENPANASLLEETELICLNDVTSPLRAVEHSAVLLKDKVEPIRLQDGGSLTPDFMENSANASILEETELICVNDVTSTSRTMGHSSVVLKENEEPIRFQDSSLTPDFKENPASTFLVEETELICLNDVTSPSRAMEHSTVFIEEKEELVRHQNITLTQDFMENPANSSLREETELICLNDVTSTSEVAETPEDVLEGIELMSIHDISLDEVSESVTTNQTSVEISKERDTDQADITSLESEYIVVPSPNSMPENSTDNCVSDKKEMKETSLRISSLSEMAPRDVTSHTEAALESESSSFNSMSVAAETNQYSGELLDLADAYNIVVGNEGHYDSNGRQQIENWMKKDTSRVSEDLKALLTQISASRGIEFLSPRDVSPKISVNSSDQETKNLDHDMQLLLQKRMLERNESNLSLEGVSVTEIEGESEGDRLKRQVDYDRKLLTGLYKELEEERSASAVATNQAMAMITRLQEEKASFQMEALQNLRMMEEQAEYDMEAIQRLNDLLVEREKLIQDLEAEIEYFRDQTPQKKNKLDVAEKVTEMDSPSEGMSNKIQSCLVGFDEERLYITSCLEKIENRVNGKAHDDNLPAQESVSELHERVERLKGDLYFLEQVMNSLGHGNEGVQFVKEIASHLQTLRSLSMKRQDQTEC
The following text describes a protein:
Function:
Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MMSGIEHCQEEGHMEEDSGEFPGLYNRENDFAEVDMEPEHDEEEEKESLKKKDKHKKDKAPGYVAFEEEDSDEESPSKGKRKGLFRNRFSQNSKRKFKDKERDKDKDKEKEKAKEKEKEKKEEKSHHKEKEKKKSSSLPRDLTPDILRSYSFKEKSGRKREAKEAKSPSQAQALSADELSSPAREPPQPIFGIPLDEAVERSKLIDGIELPAIFRDCLDFIEERGLSTEGIYRISPVKSQVDALRAAYDHGEVVDLQDHDPHTVAGLLKTYLRELPDPVLTMELLPGFEDASALPGEDERIAALIQMLYQLPTCNRLLITWLIQHMVHIMDREAETKMNLQNISIVLSPTLNISHRVLNAFFSHHDQLFGDDGIRKVGRPLRWESSTMNLDDIPDSPSSIEEELQRQEALLEQLHSELGAGVEDPEKEERLWEVQRIITQLKRQLKRAKTTYASSAAKTSTKQKEKESKPTETKPKEKDTKEPETKSAAIEKPAEEKPAEKKVTEKKPAQKKPAEKKPAEKKPAQKKPAEKKPAEKKLAEKKQVEKKSSPAEAVKQEEKKVEEEKEEEKEIEKPSDQKEEVSIVAKEEAEEQKEKEEPAAAVEAAVVHQEEEKEKMKEQEEEEEDDEELELLLEEEAALIAEQEELMALQTNLQSRIEKERTEIDQLKEEIAEAMNSRETASPPQQNGMHSSSSNSSDNSSDSSSEDEEELQDILDDLVKENQELETKNSDLSLAIDRERQRCIQLKVQIRMLQRREELGCGEDGQTTDGSVTRPVTVDRETTL
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB19.
Subcellular Localization:
Secreted. Note=Following 6 weeks of nutrient starvation.
Sequence:
MKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLARRYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
The following text describes a protein:
Function:
May be involved in osteoclast differentiation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MRAKPQSPLPRNPVPAWSPPTTTTDPMLEKDAAGGDFPANLVLQLMPLKTFPAAIRGVIQSELNYSVILQWVVTMDPEPVLSWTFSGVPCGMGEKLFIRRLSCEQLGTYMCIATNSKKQLVSEPVTISLPKPIMQPTEAEPMEPDPTLSLSGGSAIGLLAAGILGAGALIAGMCFIIIQSLRTDRQRIGICS
The following text describes a protein:
Function:
G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE
The following text describes a protein:
Function:
Transporter protein required for ammonia export. Involved in acetate resistance.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes to large detergent resistant patches of the cell membrane (DRM) enriched in ergosterol and sphingolipids.
Sequence:
MSDREQSSGNTAFENPKALDSSEGEFISENNDQSRHSQESICKIYTAGKNNEYIYIGRQKFLRDDLFEAFGGTLNPGLAPAPVHKFANPAPLGLSGFALTTFVLSMFNARAQGITIPNVVVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSFGGFWLSFGAIYIPWFGILDAYKDKESDLGNALGFYLLGWALFTFGLSVCTMKSTIMFFALFFLLAVTFLLLSIANFTGEVGVTRAGGVLGVIVAFIAWYNAYAGIATRQNSYIMVHPFALPSNDKVFF