lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSGVFHLNLTKAQLKGATLAIVPGDPARSERIAKQLDNPEFLTSTREFTSWLGYINGQPIVVCSTGIGGPSTSICVEELAQLGVRTFLRIGTTGAIQPHINVGDVLITTAAVRLDGASHHFVPLEYPAVANFECTTALYNAAKAKGIEPYVGVTVSSDTFYPGQERYDTYSGKVYRNYQGLLKQWQDLNVMNYEMESSTLFTMCSALGLRAGMVAGVIVNRTQQEIPNEATIKQTEEKAVSVVITAAQALLS
The following text describes a protein:
Function:
Dynein-attachment factor required for cilia motility.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm.
Sequence:
MYGGIHEKKLTEKDMQLSCQNIREEFQKEINIEHQRINVDSAKKKAVLYHHDYEGFRQMVLGANLYTIKSKELANFGFNETNNDKIFNSSYQKYQQPTQEDINQLQLNIKEIQCKNFRDFRTLFSKYYIKPLTQENYAELMNILQMQSEDNIKKIFSIDFHVEYFFKILEVFDYSISTLKDGKELSFIVGFLDELVKIKDFMQQIKKFLKKSEKEELKEFFGRLKQSLQMEYEQIQLNQLIHTKYEELLIQYL
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MLDFRSIETFLWVVKLGSFRGAAARLNTTQPAISQRIAQLEREMGVKLLNRDHRVASPTPSGRQMMVYAEKLIGLRAQMMAEIGDRSAMRGVMRLGVAETIVHTWLPRLVKSVNQIYPNLSLEIEVDITPNLTARLLAQEIELAFVVGPLSASGVHNRVLADYPIGFLASPSLGLGKGPVTPAELARFPIITFPRKTKPYEVVREVFDRPELPPIRLHASASLATVIHMAVEGLGIAVIPDAIVENELADGRLQLLDTDLEITPLTFTASWLASPDVVAVERVAELACQIAQSSLAVDAPALARH
The following text describes a protein:
Function:
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAVSRKPKTFKLRALHSQKKFGVAGRSCEEVLRKGCLHLQLPVPGSRLCLYEDGTEVTEDYFWSIPDDSELVLLTTGQTWQGYVSDISHFLSVFQKPHAGVIQAARQLLSDERAPLRQKLLADLLGTVSENIAAETRAEDPPWFEGLEARFRSKSAYLRYSCESRIRSYLREVTSCASLVSVAAREEYLQVVGAMCQELQAARYNGSYFDRGAKAGRRLCTPEGWFSCQGPFDTDDCASRHSINPYGNRESRILFSTWNLDHIIEKKRTVVPTLAAAVGDAEGRVVDWKYFYSLLFTLDNLKLVHVACHKKTTHRLRCDPSRIYRAQAVPRRKRPICRRR
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MNKLRLSSKRNRSLSTTNSPDVDEHKHYDSLAKLQNDLSRIESSWNKVITKDANPLELALQFLDDTSVGLGHRYGEFHQLKSQIANNLQEAANEHYQTFANSIASYGQTVKYLNDSRGNISQVKGKVEGVMASLTVEDPELDELNNESMKHAKMIETLNAIEHVLLIPGRVEKFISERQFSSALESLVQGFTLAQNHHLWQISALSRTKQQLEAQENTLFDTALEELVELVYSKQKSVFSDLNFLDHVATEEGFNTLESHLHQVISIDIMEHSSKMNRQLQEFLKRLEARKAEGNSSVQLTVQNETDYDRIFSLLCVLNNMNKLSSALEQVVAKNKEELHLIVTKAVDNVRAKFPNILKMVDAIKDRSNFGISDSNFLSIVLRKLFWEIFTKFLMAAQGHRVIYEIRESMHTSSNSKYPAQKVWDEILAEIGNLLKSYTSDPTIYTSTHSRHRRSSAATSHLPQKKNLFNLQNNLVDSNATRNHANALKSLLQDMFPGFTSNSNLDLDEIYLEDDRFEEEDTLIPLSVFNMKVILESFLVFVEGTKNVIPAQFAEETVSSLVFFQEYMNNVFLPRLDRTINYFYEQQVEPNNPFALETINDSSVILKTAIDFRNLFIRLLYVMNTSYNYREGISDILLSLLHRFYTYYYNLFQNLLTSANSRFTKKLVATWLSDEELISITENILCDDDTYVPQETTALLKYCPDYDKKSGVVSKNDFFSSSTIDTITYFLGTLTWLREWLPQLKQEVNEDDYTVDVNNIDKLRSNWSFFEMVDLEKMDKMGSLKFLLTGRSLEKFNSIVKGFLELEYKLLSCLRYDVRAKCIYNITEMLHTSKWNPDATSIELNPYITALTSEIGLLENKLSQRSNDQQRQVVFVGLSYLINIGFLACSHSIRVLNTNGVKKIIRNVNVLQQTCRNISSTPEKEDMSLTLNYFAMCSMNENTVVEYYNEGKLSQYTLEEVKNILRLQFSEELYRKLRHKSGTRVVSISSNKRYEDAVNRLVTPT
The following text describes a protein:
Function:
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Sequence:
MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQFIGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPSLLKGMRAALLNLATLLLLLDLVLLIYGVFARYLLGSSPIWMDELARYLIIGAVMLALGAVWMEGGHMRVNLLEQRLSPRLAQALRLYQWLLALAFFAFAAWVSTRYALNAGRFRSLGLGVSRTWPLLSLPLGFGLLTLMLLLQGPWPRQPASTTVEGGSQA
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase, predominantly cbr1. Acts as an electron donor to reduce the Fe-S cluster in dph1-dph2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to dph1-dph2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.
Sequence:
MTDEALSIYDEIEIEDMIFDPNLQIYHYPCPCGDRFEIAIDDLRDGEDIAVCPSCSLMIRVIFEVVCSLPASTRSRIWDADNVPYLQSDLPKDGNQPAPGAVSVQA
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MRYIPISINVSDTVNFQFFFELFNVQQFYLNDPSVITYNKTRIHYTMIACSPIKTCVKHMIGPSRPHQKLIPQSLPYAYLSLGFAKPNYATKITTGQSLTIKSGMHLVGLHNMNMRSLIPKQRIISRKKWSLVSGSWMQGCTSAGLVIGLFVCNSSTEVEPVHAEVKENNKQSHGKQVYIDYSVIGIPGDGRCLFRAVAHGACVRSGKPAPNESLQRELADELRARVADEFVRRRKETEWFIEGDFDSYVSKIRKTHVWGGEPELLMASHVLKMPISVYMNDEGSGGLICIAEYGHEYGKENPINVLYDGFGHYDALHVPNKNGSRSRL
The following text describes a protein:
Function:
Catalyzes both 1,3- and 1,5-keto-enol tautomerization of the diacid 2-hydroxymuconate (2-hydroxy-2,4-hexadienedioate) to produce 2-oxo-4-hexenedioate. This reaction is highly stereoselective and produces a mixture of stereoisomers, where the (3S)-isomer of 2-oxo-4-hexenedioate predominates. Also catalyzes the tautomerization of 2-hydroxymuconate to 2-oxo-3-hexenedioate, however this reaction is slower and occurs after the tautomerization of 2-hydroxymuconate to 2-oxo-4-hexenedioate. Using 2-hydroxy-2,4-pentadienoate, phenylenolpyruvate, (p-hydroxyphenyl)-enolpyruvate and 2-hydroxy-2,4-heptadiene-1,7-dioate, YwhB is a highly efficient 1,3-keto-enol tautomerase, but clearly not a 1,5-keto-enol tautomerase. Tautomerization of the two monoacids 2-hydroxy-2,4-pentadienoate and phenylenolpyruvate produces a mixture of stereoisomers, where the (3R)-isomers predominate.
Miscellaneous:
MISCELLANEOUS: The mono- and diacids apparently bind in different orientations in the active site of YwhB, but the highly stereoselective nature of the YwhB reaction using a diacid suggests that the biological substrate for YwhB may be a diacid.
Sequence:
MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIEEMRKDHYAVAGKRLSDME
The following text describes a protein:
Function:
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for proper limb morphogenesis (By similarity).
Subcellular Localization:
Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner.
Sequence:
MSLGTTDIASETGDDSLSAITFESDIESKTKRKSFHKPPSTSPKSPYYSKPRKVTSWRSLKTAGSMPLSSRMSLTPQKLWLGSSKQGSVAQPPSPTLTSEHAWTHPPSCTPDYLTEAVRAKRADLRRSGSHGHVSGTSVYREKEDMYDEIIELKKSLHMQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGPDFVRTLAEKKPDTGWVITGLKQRIFRLEQQCKEKDNTINKLQTDMKTTNLEEMRIAMETYYEEIHRLQTLLASSEATGKKPMVEKKLGVKRQKKMSSALLNLTRSVQELTEENQSLKEDLDRMLSNSPTISKIKGYGDWSKPRLLRRIAELEKKVSSSESPKQSTSELVNPNPLVRSPSNISVQKQPKGDQSPEDLPKVAPCEEQEHLQGTVKSLREELGALQEQLLEKDLEMKQLLQSKIDLEKELETAREGEKGRQEQEQALREEVEALTKKCQELEEAKREEKNSFVAVTHEAHPELHAPSPCSRHSEPDSDNSAGEEGSSQPPAPCSEERREAAIRTLQAQWKAHRRKKREAALDEAATVLQAAFRGHLARSKLVRSKVPDSRSPSLPGLLSPLNQSSPAPRVLSPISPAEENPTQEEAVIVIQSILRGYLAQARFIASCCREIAASSQRETVSLTPSGSASPPSLRASPGVIRKELCASEELRETSASEPAPSVPYSAQGGHGDCPSSSSLEAVPSMKDAMCEERSSSPRSAGPSLAEPSPPELQPLSPPPVEDICSDDSDDIIFSPFLPRKKSPSPF
The following text describes a protein:
Function:
May play a role both in proteasomal degradation of misfolded proteins and DNA repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKVTIKNINKEIYVFEVNGDLTVAELKNLISEKHNQTPSWQTLIYSGKILEDKRTLESYNITDSGFIVMMIKKPREAPATTPAPSTTPAPSTTSAPTTTTTAEPTPTTSSTNNTSTTTPTSVPTPTNNTPATPNPTPTTSSTPGSTSTTSPQQSSDFATGTELEATIKNITDMGFARDQVLRALRLTFNNAERAIEYLVSGNIPAANDPEDEEEMEGGGGSGDNPFEALRNHPHFNLLREAISKNPSIIPGILQQLAQTNPALVRQIQENPNEFIRLFQGDGNPGGNPGQFTLQVTQEESEAIQRLQALTGMDKSTVIEAYFACDKNEELTASYLFETADDE
The following text describes a protein:
Function:
Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MPHNSSTGDELGSTDEVKVFKDEGDRDDEKLSENLLEEKSSLIDLTESEEKTVKNGTTRHESSNTLYGGSGGPGGAAGPGSKLPHGAPHPGFNMGYIVPPYSYPNGAAGGLPVSMANKMSLPPFFCHNGDHLSSPPPAHCGILPYQLDPKTMSLTRPPLYSFPTSQYPYPMISPDMLPVASSWHSPSLYSPAAGFRTPYPSSLQIYTSLSSDFYRYSPTLLPPSIHPSHPVLNSGHPAIITPGPKQDISGSGGSSHRGGDRQGASIKLESSSAGNDHDSSSGHHHHHRSSSSSYHHHRSGGSHGDQHSNNNNSNHHTNHNHHNHHQNHHNNNNGSGGGGGGHKHQSLAEREAALEKKRSHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHSLSREEQSVYYDKARQERQLHMELYPGWTARDNYGYGAKKKKRKKDRSPADPGGNSMKKCRARYGLDQQNQWCKPCRRKKKCIRYKEAGGGDRGGDGSSDREGGRDRGDGSDDAIGSCGSMEDDSSKSPGEEDEDRESINQSLSSPRCLSVLSSLQSPSTSIASPLNLLASPATPTNFYHHHDHLGLASMIASAQQQHQQQQLQQQLQQHQQQQQQHYLHQHHHHHHHHHQQAAAAAAVAAAALQNVSDKLNNISNDSGIGGSQLNNSYSNNFSPYNNHHTMRTNSSSSSASNGNGGGGGGGGASGNLNSSSSSTTNGTGGGGGLGKSPTAMLLPPTPSTPTLAPPTPSSSSSSSSSSSSSSSSSLSSSSSSTPSLQIPPHLQQLNLKTSPPLLPNTPPSSGGSSVSSTTALTIKEELPDSSTGNGPMGSPSSGSLHPTSSSSPPTTTGVGGGGGVGGGFLLHPAHHHHHLASLHQLGHTQLHATSKTNGDLSPTTTTTAAGTAGGVSNSGDGGPAVVINGSTSRSSSSNSSSSQIASDR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Sequence:
MTEYLKDLASVKPGEPMPPVNLGPYDNPLLWNKLDPFGADRGHQRRPMTVSRDFMELNQVPIVYRDHCVHRWIPFNRCMRNLKPVTWGTVNCHEFEESWMVCRAHETYRLQLLKSKFMELTKDYTAEDKKFFPSILYLGIPYYMPSFYWNLATSQRLSGWDEKDPANPVMWREPNRSLMRSEFSPTNWEKGTMTSAYGHKLIPDEIVHEMVPGFPLPEEKRPQAA
The following text describes a protein:
Function:
Acts as a tissue-autonomous lipid modulator, preventing ectopic lipid accumulation in salivary gland (a non-adipose tissue) and in promoting lipid storage in fat tissue. Required for the growth and maturation of small nascent lipid droplets (LDs) into larger mature LDs.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet. Note=Localizes at endoplasmic reticulum-lipid droplets (ER-LD) contact sites.
Sequence:
MNILLRLIVFALDPLGLGRRFLIRPAVNLGWNVYDRVRSKADEKVGTVRELVLRLGLIAFAVVLIIWLAVFMYAAFYYVYMPAISHTRPVHMQFKTCLETSTPCTFPHAHVSLTKKQQLLMVGQAYKVIVNIDMPESPQNLELGMFMVCAEMRDYDSMLRGHSCRSAMMRYRSPLIRMISTWVLSPLYVLGWKEEFQQVPVEIFSRYLEERQHPITDVYVEIQSQKIQFYTVTLHIVADFTGLRYIMFNWPVLSAIVAISTNLFFILVVFLLSWYHWSDAKWLHSVQIKYARLTKSLEPGVIHSKASSLRDDDDDLVAYSDKSDIADVGGDTLSDVDADDLVLVKKSRSGKRESPDALRKRPTKKTTADH
The following text describes a protein:
Function:
Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (By similarity).
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MAASSRAQVLDLYRAMLRESKRFGAYNYRTYAIRRIRDAFRENKNVKDPVEIQALVNKAKRDLGIIRRQVHIGQMYSTDKLVIENQEKPRA
The following text describes a protein:
Function:
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs.
Subcellular Localization:
Secreted.
Sequence:
KCNMATCATQHLANFLDRSRNNLGTIFSPTKVGSNTY
The following text describes a protein:
Function:
G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production. Plays an important role in microglial function, controlling morphology and phagocytosis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAATSADLLTTLPYEKAFQGNQNNLALNASETQRNENCSLEDNALSFALISFYSVIFVIGLVGNIIALFAFLCIHQKRNSIQVYLLNVAIADLLLIFCLPFRILYHISNNTWMFGWILCKIVGTLFYMNMYISIILLGLISLDRYVKINKSVKRPKMLTTTRSVHICCIVWAVALTGFSLVVVPSLFRSDISNSTLCFHYRNKKNAMTEAILNYIIVIMFWTVFLLLILSYVKIAKNLLKISRKRANFPNAVKYTQTARNSFIVLIIFTVCFVPYHMFRFVYITSQLQNPSCYWKGIIHTCNEVMLIFSSFNSCLDPVMYFLMSSSVRKTVLQLICRRIHGDSSVTLESTSEIKLGQYMQERLSTTTPHSSSVKKKSDLIK
The following text describes a protein:
Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MHVLDGSSGGGQLVRTALTCAAVSGESFRMRYVRRARSNPGLQAQHCAAVNAVADICDAATDGVEVGSEAFSFEPEVAAEEADDDEEPTLGGTTSVEVGTAGSIPLVFDSLLPLAGALDEPITATLTGGTDAKWAPPMDYFQHVKLPLLREHGIDATVSVDRRGFYPRGGGEATLTVEPSTPTPITLTERGDREALTAYSVAESSLADDEVAEQQATAAAPDAAHEIAYTDADSAGSAVVLAAEYEHSRAGFAALGERGVSADAVGENAADALAAFESGPGAVDSHLADQLVPVVAVAGGEVRAPEVTTHIETCVDLLAEFDYDIDIEHTDDGAVVLSA
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex.
Sequence:
MPRELRTLVAASFDIFARVQQQTHQLGAFGIARASREYREALKTCIFALEDRLEERKDTSAEEEEKFLDLLKVSLAIWHLCELLLLRGGVRGADRTLAYDLGMWLQEHYCSTLLENTEGDSVRLKKEQKPEQDPAFWSTIQSLVMAGSGVSAWTLLATHSSYKSLFSRDAASLTGASMKASFQAVQRLLLSMPGSTGSSHMNMEQDGPVEWKNWHDACQYLLNTDGYIKSNAGLTTLLEIMVAKEDVLKSHATTWYELMMARLFLDEPKTIAHRFEYLMANCFRAYNSDKTSMGNFDCIILAILEYDVQSALQDIIALGFSWMAAHLADLLQKNNVIIADELLPQAECTLRERFLLEYAMEIGASSGMWQFAVRYYEYCPKFGAIAIRSALEREPLPTDYKAERLLAYCHGKKVLTQTQRRISIMRAQESIAKKTYASALQWMLRGNHLDDVDALCDDILEECNNSSSLTPLHEAVQFMVGHPEFARPQKLAWLVRYREFHLVLDDCESLQQQLRTGDFSDNRSERAGLETKLRFVSMEAAKRLDWLFSSAEAPKSLRSEVLKQAEHLLKESPTVFGSRHLYSLMAYLQQLDRSFDRQNFYASGSNKQLKERIESLISRNLAEAMLQEASACGTASTVSAPNSQANAALVSQQTYLIADASFTLMED
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MEAAAAAVVAAAVGTAVAVEAAPVEACCGPAGTVATAPRAAAPANAGGAVLEAATELATGDARTPAGIAPRPSYCFRYCFRCEPTNPYDVNAVQVWWMRGERHEADAQAAAAAEPAPGGDALPGVQTRDALAEAPVSAEVLVGYLPREVAQHLAPLLRAGAVEVAAGAAGLQVDWAGLGRARSGGRAAPLHAYLRPRQRWRREGVGGNGRVGCDRSGVGCSNGKVDCGSSGGCQDEPQVAVPGAAAVHQSAASYGAVQDEGEEDEEGEGGDSDGEVGRALDAALAGAAAWRCQLRRGGPGGSNSSGSEGGAGAGAAAAAGDGGPVEGGSGPEAGPGWGSGAEAAPGEVLRRNFAMMAADVQRYDGHLLCGEEQELLGRLLALPPPPQCLFLRLLLRRGPWFAVRDIQYPECGGGGGGGGTEAEAAEAGAGAGAGASAGGGAGAAAAEKPWTVDAAAEALVAAGLAERPQPHDWPQLAQQLLVVADVRALMLTCAAAGGGDSSRRSSGGGAVAAVSTPVPPHTLPQRGSILAFATRRRTAGGGGAGVNGTNGGGNWGAAVKAEEGDVLLSPPSAPGTASGSRNPYLPTHKPQPQQGQQPNQQSFAGGAMPYAGPRAEGYRGSAGSRRSMGGRGGASSQRVGSDGEGASGGGGEGGSGVRSSSGAARHWSAPSRGGTSTGGGVAAATAGGGGGGGGGSSKAAVIATLRQRYANDDDMSRRVSSLTGPCLRLAPAALLLVSRLQRLYFLAEGPAADLGRFLAADRGVIRYPAYTVRRSGSAFGSRQQLLDYEAALRAAAELDAALEAGDEAAAERALELALAAVRAGAHRQVHWCGDATIPVRAVPGPWPWLAAHEHGGAEAAAAAADVGLCAGAAGAASATAAAVAAVAAAGAASRGSAGGAAGTAPRHAESPQRHRRASCAGGVGGAGVGAGGGSRAEAMDLTFSSSDSSEEGKDDTDDEAGRDGDSDDLMLGEAGSGAEAQCTATGGLPAAVGFKQEVEGAEAEDARLGSDFGFVTDAGGAAGATAGAAGSPGPQQEQEEVDAEEGWGLDPPADVHADDGLWGTEPELEAHPEQGLEAEPEPDLEQSPGLGTGGRSDGNGPGADGETEAGDIDIAYGDEEEHMAGLGHSGDCAGDVAGLGGDSGGEAAARGGSAPAAAAALPAADAATDTPAAVQPAADPPQSATGVTANAAATADAPPAPPQQFLARFCAAWVYASMGTVAVSLLERQRRYGPAACLLRALLQGRCCPGRRGEWWLRLSLDLQHLGREEESLQVAEASLSDPWVRHGDRLALQRRVLRLGRPPRRWKKPAWAAAALAEPREVVVSAQLIKGATGYKSRFIAPAAEPGTAAAATTAPRAACGPADPAQPQAPVQWKPPHRSSSPSPQRGLEPPVAGGAAVAADPQQPVATVGVEDLALHHYASAPGGGWRGVHSEGGVWGCLWALLMWDVLFTDVPEVFRHPFQTAPLDLDSDAFYPARRAAVDARLQAIAGGAAPELLRAAWRSHCGVWCRGVNWGRLPLEDLVDIARCVGGLGLSVVCRLLSEDSGGWRGGMPDLLLWRPERGDALVSEVKGPRDRLSDQQRAWMAALAAAEVRVEVLRVVEAPPVGAARAAGGRRHLPGRGRSAVAVPVAGTSGAGTSGGNGAAATAAVGRRGGMRSRGGRSGVAAAAAGAGEAVDMVDLLASSDGD
The following text describes a protein:
Function:
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTPEAKRKKNQKKKLRQKQKKAAEKATDLPATDQSVNISGAEDALTSNSNVSTPDYTSNFEISVTSTQEVNVDSQLSQNQNSDNFINEQKENDPQSETVFDSHEDIESEMKDNYHNDIKNTTEAITFDTAQNIIGGSIDSSNTVKSEDKINESSSKISDPDCQEDILKLELEGQPLESSCNDDKESVVEGNNENDNNDDLVNDHPTAEDGSDFFDNLASNNTEVELSSTQNSNLLTENRLESEEFGKPEKLDYPKELSYSEEVDLVEEVDHVEEVDHVEEVDHSEEEDLVEEVDHVEEVDHSEEVDHSEEVDHVEEVDHSEELLTSSVSTQTGMAENTIRHVDESNLGQQKMEERNINSDTHKDATARVSDFHANDEFETGPAAQINSLIEMNDDEQSVNDLQDESSLLQEETTFSQIPKNEVNTENQENIGSESVSKINVANENSMESAIEDLFPSMHNTNEQNPWELPQQGENVVENEVSHEENQRITETTKDDSDNIDRILCDREDKKEDSFDDLFGNNEVGDDVPWLQESMKSEEGEKHHQSSTAKEESPANVRTSDNTASQDNDTLPSESVKSNQQQNVESSSDRQQTSADTVKKFSFLEEDDDLLDDDDSFLESEEEIEELESNETVQINELTQEMSTSAESKKLNHNPYRPSSHSSINTQMDPKYNNYQTVPNSSTAPTGIVRPQQITTFLPTNNAQTNTPGTILSPIQTTNEKVKKLTEEKKKSDAYDFPINLVSSTVKKGHAKPVGVFTNQFSRNGSTPTTPKINPHSRNSSVNPAQIIPKNPYASIQQPNPVIAPTTNMINNPINMMPTARMRGNSAVSTTSGKSVGTSVATKQNPYSPQITKSPRASISQPAGIPNNSKYGPISPSTSQFNSLGQVLDSGLVHSSTTPMGSTLSPISTKLNANNQPSPQSKQYPGNSSYLPSQNDSRSKYAPAFSTGQYAGYSSHSKPAVNQPALPFPRKQSESAGDANPPINTVLPPGIRKTNVLLESQQNLRQNANYPTYAEHSHEQTNSYNVHGASNKKIVNNNALLVKQFPIFNWGSNNKVIYGIPLGQNDSVMMPTNSPLQNLRMIGAEILIKPTQLIKSFPGPLCGSKVKKSDVEQWLLTASKDADVDEEAALLLSLLKLKLSTTSTFKDMATLLYDTATLHEYLAQPLTSLNQAPNAFSLDPESQFRVLSFLQVGAHDDALRFSLEKKDYSISLLIGSLLGKDKWCEVVQRYLSEQFTAIANNSNLWAHLLPLIFQVFVGSSKTAVSRFYKNQEEANWAAENWRGIVAAVLINITDHSQPKQTASIQTPPAVVTEFLIEFGIFLKKLGMNLPASILFVIANVPLSNVPILPDSDVHFRSIGSTNNVLGAILSETYEYTISQDLKFKGYPATLPLKLFHAYCLQEEGLTSLAYKYVDYLSSATKSMTKKDAESLNLSHHLSILTNRLAGSSSSWLGKPKLSSVWGQIDKSFNKYIGGDDDLPKPATEKKVFDSYTPSSSTNSSMIDLSHSVSNFMPAQINQLSRNNLNSENKMSTVPDLTAFGEKNAFEPPTNTWTGMSLQGSPQRAVSNMKPPLSNRPNLRRIKTELPSGEDELLSMTVKQGKKSYAPDNLNRASNSSNETLKSSQSANNSVPYHQSTPNLIGMQSVEQKKSYYPSNQRAMRKSAMPTQPENLEISRNARSYEPHTKTKKVYKPNQTLEEEPPIQSYNDDVVSQNQFEEAPNLQNDQEKILQPTASPEGLSQTRISNYSPERPPLPVYSEDSKNMDPKNISDLVKEQQITDKSLEHELEQLPTENDADYKISNANEDNAINEEEREIGNGEVELNVDQSQSHLSASIPQTQNDRESTTVSISPGLGLEMDVDKEDSNAPAPKLFSEKPNPSPYAPPTVGKKGTKKTSYMPKGKTESFIAEPEISSYESSPLDMYAYSGYRPQEKEKSTSSIVEESSQISNEDAPDKSSIAARQAVELKQDEVSKKPITTKLSTPKSLPIPPSPFANPLANNNTTGVLPTENFEPVIKVSRNTTARAFTPVPPASDQYDDVVEEDSDDSDDSEDDSPMQSNNSNNGNSERNENKQNDNYSDDEMPTKKKSHDNNDAGSGWFGWLKKDTNEKKAVKAKLGNQNSFYYDEQLKRWVNKNASEEDKQQLATPAPPPPIVKRKDTEPKTKPRSISGVTPHLDTGIGSSIPPISGNAPPKPKSGPSLAAKTNGLDDLLNLTAAAPATSTRRKKKGGRGYVNVMENL
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MRSFTAMRGSSEAENFVKKPNLLKKCGWEHSGQSSRWLIKLWITFKRIIRKKSTEQFSCMPYLISLLQCLLAAWYSLPFVSPNNLLVTVISAIGIGLEATYVLIFLIFSPKKGKAKICGYLFVVLSIFSSLALVSMLAFHGNRRKLFCGFAFAAACIMMYGSPLSVMRLVIKSKSVEYMPFFLSLSVFINSTSWSIFSLLGKDPFIFVPNAAGTILGAAQLILYVVYRDKKGVKKDEINESVDQMRTGKLQDGKLVDIQNENANP
The following text describes a protein:
Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MASIDFRYSIRDFVSEVPNAKNGNCNGKYSRFDQELRGRWDEAVEKGYFRYELGSLPTRVIEGPHGFVAQLNVKRATERRKPQEIKSTKQPFKPEEFNFNKVRPHETLMEMHPEDLSCSSINGITNGNGIVRSHAEREECMNGEGGRSKYQVIINISPLEYGNVLLVPSPHLCQPQIATMEMIQIGVEAVLLSSSSALRIGYNSLCAYASVNHLHMHAYYVHHRLPVEYWPTKEVVGGQVHETIGWPAQAFMLQMKKESYFDGIRDLFRIVKHLQDRDIAHNMFFTRGLTLGPNPQEDGQTIRLILWPRVSSFGIKGNDAFNGACCELSGHLPIKLEQRYDDLTDEQCCELLESNSLSPEDYAALKKDIKNIFK
The following text describes a protein:
Function:
Efflux system for nickel and cobalt.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVIFSQRTPGRRWLSLWPLALFLLLMLVGGLWMWQAWPQVMLKSALWQRDVNQQLSALLNAVATHPERAGGSLLLLSFMYGVLHALGPGHGKVVIATWLATHPSKLKSSIVLTLAAALLQGLVAIGLVVGVLTVLQLPARQLHLSGFWLEKGSYALVGGLGILLCWRAIKRLRALLRKPVFIAFTPRHVHHEKCGCGHQHLPTQEQLHSGDDWRARFMIVLSMGMRPCSGAIMVLLFSKVIGVFSWGMASVLAMAAGTSLTITSLALLVHTFRALAVKLSGNKAPALWRQVGWSTLALAGGGILLVAALVMWFSVPQPVGGLRPWRG
The following text describes a protein:
Function:
Probable metalloprotease.
Sequence:
MNLATIKVTLPELIGRYQSQADFISIRLEQSEGTQISLRSDQVETLSEGIAMGGQVRVCHQGGWGFASFNRWEQLRQRLEEAIAAARLIGDDETLLAPIDPVQQTFINPLTGKDPRQISLADKKALCDHYNDLLRGTSDKITTTHVRYSDSQQTVLLATSEGTLLEQCWWDLEMRFAATAKDGNGVQVGRETTGSRRGYGDLENLDQVVQGAAQRAVKALTLPTVQGKTYPVVIDPILTGLFVHEAFGHLSEADMLYENPDFLEVMSLGRRFGPPELQIFDGAAPPGHRGSYGFDDEGVPASTTQLIKDGELVGRLHSRETAGKLGEKPTGNARCLNYHYPPIVRMTNTWIGRGETPVANLLDGIEEGIYAQNWLGGMTNGEMFTFSAGEAWMIRHGQLAEPVKDVTLSGNVFKTLANIEAIADDFYWDESGGCGKGGQNGLAVGCGGPSLRIRDVVVGGDAA
The following text describes a protein:
Function:
Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MKHLILGTAGHIDHGKTSLVRALTGIDTDRLPEEKARGITIELGFAHLELPGGLQFGIVDVPGHERFVRTMVAGVGGMDLVMLVIAADEGVMPQTREHLEICQLLGVKKGLVALTKSDMVDPDWLELVVEEVRDYLAGSFLEEAPIVPVSSRTGAGIEAVKAELARLAGQVDEKKTEGPFRLPVDRVFTVTGFGTVVTGTLLSGAISVGDEVELLPSGLSARVRGVQTHGRRGDAASAGQRVAVNLQGVEHTEVGRGDIVVPRGVYRTTRAVDARLDYLPSAPRELRHRSTLRLHSATYEVPAQVILLDRDVLAPGDSTFVQLRLRHPVLLLPGDPFVLRSYSPQATLGGGKVLDPMPPRRRRRSDEALALLEALGERSESDTVRLLVSGSLLTGICFEDIVVRGGLSARRAEATMATLLSSGEVVQMVREPRIFLSRASFVSLKGGLLSEVEGYLRDNPLREGLGKEELKTRLPRRSDPRFFTPLLTSLEKEGKIVVDRDLVKLPGRKGTITVDQADLQVRLEKALQRGGYEPPTIKEMCDSLRCAEKMLLEHLNILAREERAVKVKSDIFYAPEPVADIREKLMAYLREKGEIMPPEFRELTGLSRKFMIPLLEFFDQEKITIRVGDKRVLRRG