lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
Subcellular Localization:
Lysosome.
Sequence:
MELWKSCIFLFLNFCIQSEGIVRTSYGNWNIPKIGDRNIPSFLIDESKNQFLLDGLPFRYISGSIHYFRIPRDRWDERLGKVRALGFNAIQYYIPWNMHELEEGNHDFSGLLDFAEFSMMAFHKYGLWTILRVGPYICGELENGGLPWWLLNKNVTKQRSSDRVFTREVENWFEILLPRVKPLLRKNGGPVLMLQIENEYGSYDACDQQYLRFLRDLTRSLVGDDVLLFTTDGSAESLLKCGTVEGVFPTVDFGPTDDAKEIENNFKLQRKFAPNGPLVNSEYYPGWLVLWGQKKQNLPSPQTIINGSQTMYSLGASFNYYMIHGGTNFGFWNGAETEAPCITSYDYDAPISESGDVTTKYLEIRKWIKGLTDWPTPPLDVPGNSPKGRFGKIKMRLVHSVEKLKTLTSLGDPGDCVETDKPISFETLKHPLGLVAYQAKINSCGNLTIPSFGDFVHVYLNGKYIDTLTRRYYNLTRNSVIIEGCLENEENRLFMLVENQGRKTFETINDRKGILSDVFMNGQAIQFWTQCGIKLPLQEDFYFRKAMRNNYRKNVKSNQKQGVFIGILSVDAPTDTWLDTTGWGKGIAIVNGRNFGRYWPTKGPQMTLYIPAEFLKIGENSVMMVELEGAEEACTSTSSCIADFIDHPVFDFQ
The following text describes a protein:
Function:
Histone methyltransferase that monomethylates 'Lys-5', 'Lys-8' and 'Lys-12' of histone H4 (H4K5me1, H4K8me1 and H4K12me1, respectively), thereby controlling gene expression and remodeling chromatin structures.
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm.
Sequence:
MTQDISEKIEVISINDSQPEDSSPVVPHERQVVDCVIEIWKEDPSTESLGMSKLHALVKQKHPNWSISEKRVRSLLKQFGLAFNNQEQFTYAKEITSVMTPDIELPANVHIIMTSKRGKGLYAKRDIAKGDLIWSEEPLFFIPPLANVNLMKTASACTYCGKLLQRTESATVLKGLDCNVCSEVWCSIKCKHLDGNLHSLLKHNLYNPGSKKHKLIDAEAFLELQDYCLEEQWNALYAITLIYANCITDKSGVKQKQFDAMARVSQDVRYKALNSSAGTFDSLNGGALFVQEQQEHLWKIGYEKFLRVFPKKPVEYREFLFMMGTYNINNLDSNVFLTQSHLNHNCASNTSVETELNRTAGLKVIAGRDIKSGEELTTTYVNPSHTVHQRQRELRVNWGFICACAKCKDDLKQNERRKSSHNQQQNANNIRDMLKETKDAVGEEGIELEIPTEFNGERRKSVRFDEKVVAVKE
The following text describes a protein:
Function:
Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.
Sequence:
MLYIILATYHEESNIGAVVFHLVRILEEPFFLIIDDSEDNSTRVAVLQAFTALRFSNYKYIHRGQKRGLGTAYRCAMKELTALASNNVNEADDMVAILDSDLSHDPCDIAKLATCMRETGADIVAGSRYRTGGSVSGWPRRRIAISSTANFLAQTVLGIRVTDCTSSMRVYKLSTIMSIIDQTRSTGFSIQLELISLASMYGYKLLEVPICFSERVNGSSSLSCKEIYKFLMLIAHLWWKQRTSEARRTLCGQ
The following text describes a protein:
Function:
Probable transcription factor. Required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage.
Subcellular Localization:
Nucleus.
Sequence:
MILHGFHLSTSSHCLPFIFRHLFIFHSITALCDHVISNYCNSLKLSNNKFNQMLSKFVVVEVSNSNNTMTLVEYLVTHGFDKFAVVTDLVDHPSFKYKDGSSSPESPSTTASTAAQHTPPRTAVSTPTSINTPVPPHQNKQRHSIDKIAANLSTKKVSPSSIEKQLQRTSHNPLHQLSTPHALSQLQKLLEEQHKINQMNIQKKEQERQQAEIQRILLQQANAAQINHSFGLERLTPEYDDNHHSETISKASSEDLKTEPDSTDFGLGTSDDQVRASMLHLLHPVFAPAFGMLDAENIFGAASKPTTPASKRRNTDSNGAPSKKHRWLPVNELEESRSSRGKNCGRVHCKATYKCALCGKPTTLNSTGSRWNLLRHVIMIHSDCKPYKCWDCDFTGIKSNVISHARQCRHNAEDAHDITTDEMRAEWNLRLHECFPDYVRAKERGWQPEEVTVKKEEVEESPTLVKQELTLVKQEPTFAEQLEPMAQPLV
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MALRNHTTVSEFNFCRITQSQELSLLLFFFLSTVYVTTVLANVAIMVTVTWESHQHTPMYFLLHNLSILDICFSPLTAPKVLVDLLPRRKTISFNGCITQMFFFHLLGGPLHYVNIMSRGRCTALIVASWLGGFDYSIVKSSLLLPLPLCGPNIVDGFCYDVPQVLKLACTNTLLLMISNNGLVITLWFVLLLVSYTVILVMLRAHMGEGRKKAISTCTAHITVVNLHFVPLIYIYAQPFTALSMDRAVSITFTVIIPVLNPMIHTLRNQEMKSAMRRLNGRLMLSAMG
The following text describes a protein:
Function:
Vacuolar multi-drug resistance ABC transporter that may be involved in the transport of bilirubin and glutathione conjugates (By similarity). Plays an important role in virulence.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Associates with lipid rafts in a RTA2-dependent manner.
Sequence:
MNESNRELILGLSPVHLSLFNSESLLHTFNFFGVGDGQANIASNYVTASKFVIPQPLYSPHGNALNPAFVELIGQAVNTFFAIFMLFQLTRLLLTKKKSHRIYTPTPFSQTLKISLVLLQVILVASLYFLNKNSYFIGGIAATVLALILHLVEFRRSPIAIESLLTYWSANTAFTFAVFIQDSYSKHKIYANSGPAYVIEIISLVNSFLIFVFEVGYYKPGFEITNEKFLDTVNLFSYFTFYYLQPLINKIYATDDVQLTDLPDILGNITCDDTKAKVAKAWEEELKRTKKPGLVSKVWSFVTRRKVNSKPQMFLAIAKAFFDKFAISITLAIIVTGLSFLQPFLLRKFIQFFSTYFYSVEKPPIIIGYFWASVMFLTSVANFIAFNQAFKTQFDLGYEIQSSLTTLIYEKALRLSPQSRKNKPTGDIINHITMDIDIIFWFCWQLGEYLASPLKLAVCLAALYKLFSNATWAGVITAIIVAPLATLVNASMSKNYIQLMKDKDERTSLITEILNSAKSIKFYSWEKPMLARLSHIRNDRELNNIKKIGVVSALAQFLWSCIPFFISCATYATYAYFYNVPLTPDIVFPALALFDLLSEPMLLIPSFIVEVIEVSTSLARIGELLCLDELADDQHGYVKRDPEPNDNSIYSVIVKDATFVWSEETQQKQYTDEESEVQEVPASNVALKNINFSARKGELACIVGKVGSGKSTLIKAILGDVPIKIPSYSDDSTNPTPSVETFGSIAYCPQNPWILNGTVKENILFGHKYDAEFYQKTIDACELISDFKNLPDGDQTVVGEKGISLSGGQKARISLARSVYTRADIYLLDDILSAVDAHVGKNIIKKVLSNEGLIGNRCRILATNSVPVLHEANDIYLIAGGAFVEHGKFKEVMKRNGDLAKLIKEYGRKKDEPTEEETTEASTEPKEEDHSNGKSDTAVHDELDTDELVDEIVDYVGEQNRGVVEQAILRRASVVSYGHNYENDEADNGQIRKTRHEQEESRKGTVPWDIFKQYIIACDYKYFSFYVAATFSVVLISAGEKYLLSYWSQLNSEQNDTVEPVFFLGTYATLGVVSGFLTYMGALVIWSYCIVKGSTYFHNKMAESVLRSPMSFFDTTPIGRILNRFTEDIGKIDMNLPWTIISFITTLLNGFVTFGVILSFLPLMLVVIVSLLFVYNYFRIRFVPTTRELKRLESIAKSPVLATIQESINGVETIKAFHQRERFVYKSKKLIDEKTLIGVVQQNCNRWLSMRLQTISSSIMFFTALLAVVTLGGKHPILPSILGFVMTYSMSITYILNSLVRIWAEMQAGGVAIERIIEYCDLPSEAPMIIEDKRPQDSWPAHGVVKFKKYSTAYRKHLDPVLREIELTINSKEKVGIVGRTGAGKSSLTLALFRIIEATGGNIEIDGVDTSQIGLYDLRHHLTIIPQEAHTFRASVRENLDPFGEYSDDKLWKVLELAHLKEHVTKMETDPTEEEKKASKNPDELSKKVGLDAQIEEGGSNLSSGQKQLLCLARALLNETSKILVLDEATAAVDFQTDKIIQETIRTEFKDKTILTIAHRIDTIMDSDKILVLDSGKVAEFDSPQNLLKNKDSIFYSLAKEGGYID
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MRSFSFSSIPNLEDLSISSFSTSPSGESRSYGTGYSRGPVCMEKVHMHLIDPEASILLKEIAELMILAGHAPNICRDYGETRHHMLMQFLSLLGVQIEQKSHNNPAAATANGACSMQLYEKNQKMWIQALRVVVSIVLPEERDACAQIFGCDHKVEEDCFARATTRCTGELLAVGSMMASVKVNDQQYHKVPLLLQMHEEFTKLEPSISGLLSGDAKGVISEQASMLLGKLGETASNLLLEFLNVCSNLEPCQNTMLDGDILPLTRHVMGFVEQLNEYSDTINLILLLVVDEEEEDKEITKSPWERYMLMLLARLQVKVEEKAESYKDERLRYIFLMNNAMHVLKGSGSSDLSMSVWDDWNRQQLVVRVERYATAYLRASWTGALFQLSDQVVPSDHMRYETNWVKKEL
The following text describes a protein:
Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAQSQGWVKRYFKAFCKGFFVAVPVAVTFLDQVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVQRGDIVSLVSPKNPEQKIIKRVIALEGDIVKTMGHKNRYVKVPRGHIWVEGDHHGHSFDSNSFGPVSLGLLHAHATHILWPPERWQKLESVLPPERLPVQTEEECLHGSP
The following text describes a protein:
Function:
Probable purine-cytosine permease.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPQTHEMSLNGTQYLKYELKDLESRAHDAKTPSTNEFYDDVESHGTEELVEAKLSFLNRIAAGLSAETKGIEPITEDEKTDDSILNAASMWFSANMVLPAYAIGALGPMVFDLNFGQSVFVIIFFNLLGLVSVAFFSVFGAELGLRQMILSRYLVGNIAARIFSFINFIACIGWGIVNTVASSQVLNMVNPGHQCPLWAGCIVIIGATVIVTFFGYGVIHAYEKWAWVPNFAVFLVIIARLARSKKFVLGEWTSGPTTAGNVLSFGSTVYGFAAGWTTYAADYTVYMPRKTNKYKIFFSLVVGLATPLYFTMILGAAVAMAAIGDPAWKTYYDENSIGGLTFAVLVPNSVHGFGQFCCVLLSLSTIANNVPNMYTIALSVQATWEPLAKVPRVIWTLLGNAAALGIAIPACYYFSTFMNYFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNVDDWDSWERLPIGIAGTAALIVGAFGVALGMCQTYWVGEISRLIGDYGGDIGFELGLSWAFIVYNIARPFELKYFGR
The following text describes a protein:
Function:
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MRRYSLLFFVLTVWAWTLNGEGAGEEGVEAPEEATPEPPSDELLEEDDILVLTQHNFGRALQEHRYLLVEFYAPWCGHCRALAPEYAKAASLLKNESSELKLAKVDGPAEKELAEEFGVTGYPALKFFKDGNRSQPVEFTGPREAEGIVRWLKRRLGPSATRLETEAEAAQFIDSQDIVIVGFFKDLQDEDVAGFLAIAEDAVDLTFGLTDRPELFQKYDLSRDTVVLFKKFDEGRADFPVDEELGLDQADLTHFLVVHSMHLVTEFNSQTSSKIFEARILNHLLLFINQTLSPHRELLKGFQEAAPAFRGEILFVVVDVAGENDHVLQYFGMNATDAPTLRLINVETTKKYVPGAGGEITAASVSAFCQDVLSGKVKPHLRSQEIPADWDQKPVKVLVGKNFEEVAFDASKNVFVKFYAPWCTHCKEMAQTWEDLAEKYKDREDIVIAELDSTANELEAFAIRGFPTLKYFPAGPDRKVIEYKSSRDLETFSKFLDNGGVLPEPEPKEPEVPLPEAGANDSKDHKDEL
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MGSFTSCDQRPTASTTAAPHSYDADKVLRNFDTSTPTAAVIGAGITGVHIAYELAQLGFRVTVFEQRRDIGLGETQYALPFVGVGLLHPYIHSIRMGRELLWSKLKLNSKDIVTVDFSWNFLFSSFIHRWLWARKWGKLRAEEVMKYTNNLARLSVGVIDELSHKHKTLAPYVLSRNVTVQTLEEGPRADKREAILHQAATAHRQPLMVDLVGWTRELAKVCREKYGVEFAVGEKLLDFKTTLSFGVEVVSGLRFSRNVDGRVEYKNRVFDVVVLAAGAQTGELTWESSQIPIVGLAGCSVALRPGAGEGVGELMGKLHLSSPGLVMVSPESHLVCYRTSASNDAGGEVLFLQGLLSLDCTVRTLPRVGRMLSRIEAHLREKCQINIPLLHRYRECGGRQQLDDGNTHVVTSNPVMHAAEYIRSSTPDGVPFIGDNGAAFNSFICAGFGDHAADMAPGAAKILAKFIELKACAMQRQDEKTMERDGYNIAAVMSDERVEKTRRELQLLLNGCQTIDDIPPGGELENFVQLPYSYTRFDGVVKDQIPDVAHVSLLQRVSDMEKRLLQTFAPWEHYINQQAIKLSRRDNVPDWLRTIVYYYFLDESDDLEMLKNKQKYVEGIRRIREQFEEGNETSASGATPSSSS
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTKNIEDKQGKFEELTKTPISKLILKMAIPSIMAMLIGIAYSLADTYFISKIDTISTASVGLAFSFMSVTQAFGLLYGHGSGNYMSRMESEKNRTESSKMAIDGLVISFLTGIIIMIFGELYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTMNNQFRLQGNPSLGAAAITSGAVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKILSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHGFQPVCIFNYGAKLYERVEKALKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIGSQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSRQGYIYIPLILIMPKMLGVKGILYVQPLSDFITFVISVVLVAKYKKELKC
The following text describes a protein:
Function:
Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.
Subcellular Localization:
Nucleus.
Sequence:
MTQLPSVSELINRTGSIGSSSNITRVPPMTTTSATNTTTAATATTVTSTTPRSENSYSPNSPYSLPTRPSNTSLTNYSAGSGITVASSSFQFSQPSPGRSKHNSTSSQSSSGDSFQQHQSNPSGVSMSSNTSPRTSIVQSMSSVPTPPSTGPAPQQFVYQESQLPVQPPPQQQQLQQPPPPPPQQQQHIYPQQQPNFPYHNNFVSPPTYTTAYPQYYYQPVMTPPHHQPHQQAPIHLANNVSILQSQAVMQNAYPTTHYLQHVGPHHIYANVNSQVYYQDMAREEANKALINKRRIIKRRTRTGCLTCRKRRIKCDERKPTCFNCERSKKSCLGYQDLSKLPPRKRNRDTSLDLPDGNQQQQQQQQNQQSIVGGAGNVSDEPHNETHQITSISGSSTNSRNLDMMIPQSFRNNISSQPINFYGPVATTASGASAVINRVSVADLLK
The following text describes a protein:
Function:
Homeotic protein that acts downstream of Arm in the Wg cascade during embryogenesis to determine segment identity throughout the entire trunk. Acts cooperatively with other trunk homeotic proteins to repress head homeotic genes and therefore repress head segmental identity. Necessary, in combination with Scr, for the formation of the prothoracic segment. Promotes eye development in the dorsal region of the eye disk and suppresses eye development in the ventral region in combination with Wg-signaling and several early dorso-ventral eye patterning genes. Required for proper development of proximal leg segments. Has differential functions along the dorso-ventral axs of the antennal and leg disks. May play a role in wing hinge development. Possible involvement in chromatin structure for modulation of transcription. Binds DNA and can act as both a transcriptional repressor and activator. Positively regulates its own expression as well as that of Dll. Negatively regulates the expression of mod. Required for Wg-mediated transcriptional repression of Ubx in the midgut. Also represses transcription of lab in the midgut and is necessary for the proper formation of anterior and central midgut structures. Tiptop (tio) and teashirt (tsh) have, on the whole, common activities. Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop. Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg.
Miscellaneous:
MISCELLANEOUS: The tsh tio gene pair seems to have arisen from a recent duplication event: tsh has the dominant role compared to tio.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Initially localized in the cytoplasm soon after the blastoderm stage, and becomes nuclear by stage 9.
Sequence:
MLHEALMLEIYRQALNAGALPTARPRSTESANSSERCPSHDSNSSEHGGGAGSGGVGHRLDAAALSTGVMPGEGPTTLHSSFPAVPQSLPSQPPSMEAYLHMVAAAAQQYGFPLAAAAAAGAGPRLPLPLANEAAAPFKLPPQASPTASSNNSEALDFRTNLYGRAESAEPPASEGEEEEFDDGANNPLDLSVGTRKRGHESEPQLGHIQVKKMFKSDSPPANSVASPSASQLLPGVNPYLAAVAAANIFRAGQFPDWNSKNDLVVDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKSPVQPTPNQNSESGGGSGGGAAGSGAVTKARHNIWQSHWQNKGVASSVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKSGNANANSDAKESHNSLSSEESRTLSAVLTCKVCDKAFNSLGDLSNHMAKNNHYAEPLLQSAGARKRPAPKKREKSLPVRKLLEMKGGSGTTQEDHSNEKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNKSPELVEQKNGGSAKAAGASSVLSAIEQMFTTSFDTPPRHASLPASSPSNSSTKNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYRYTSSERSGSECSAEARPRLDAPTPEKQQQGGGHDEESSKPAIKQEREAESKPVKMEIKSEFVDEPNEAEETSKMEAAVVNGSATNNNNNIVERSSPKTPSSAASPQTRLLPPRSPAESQRSVTPKSPASSHKSYDGSSEGTKKFPSDSLNALSSMFDSLGSSGAGANSRAKLAAAAAAGGSESPENLTAGGNSLAALRQFCVKKEKTA
The following text describes a protein:
Function:
Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity); (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1; (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with BY55 and BTLA.
Sequence:
MEPPGDWGPPPWRSTPKTDVLRLVLYLTFLGAPCYAPALPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWVWWFLSGSLVIVIVCSTVGLIICVKRRKPRGDVVKVIVSVQRKRQEAEGEATVIEALQAPPDVTTVAVEETIPSFTGRSPNH
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
Miscellaneous:
MISCELLANEOUS: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTWQLPEHIADVLPTNARQLESAREQLLALFRVHGYELVQPPLMEYAHSLLTHIDAGLSLKTILVTDRLSGRQLGIRADITPQVARIDAHLLSANQGINRLCYAGPVLHAQPDGLLNMREPLQAGAEMYGFADIRGDIELIDLMLKSMKIADMGKVLLSLGHIGIFRALSDAAHLDAGQSATLLALMQDKDTGAVEAQVKAWKLDGMWAKAFSLLPRLYGGREVLSDARGRLPDLSAVGGALGELQAVCDAFPDCEIHIDLSELRVDNYHTGLLYAAYAADFHDAVARGGRYDGLGGYFGRARPATGFSFDLRSFIGRLPAIERQPAVLVDAEDAEAAHEAVEALREQGQCVVIDYGIGHNVSEELAGRLKKTDGVWQVVKR
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MGRMKPAQLLEKSKKKKVPAKLNVATIVIVGVVVILLLASAVVLHRRKSSDGSNESSLIDINDIDKAPEKFITTGSGEPLPRYATLNTTKGVFIIELFGNHAPLAVENFVTLSKKGYYDGLLFHRVIKNFIIQTGDPKGDGTGGESKWGASFKDEFSELTHEAFTVSMANIGKPNTNRSQFFVTTVATPHLDGKYTVFGRILRGQDVVQAIEKVDTDGKEKPLIPVKIRSIKISDEL
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MSHQAPPFSLIQILSPPYPSLSITPSTKPFLSGEVPFLSSCLKPNSEKNQKRERERAKEMTGQFQKSSMYMEHNPGIVENGDFRKNLDDDGRPKRTGTWMTASAHIITAVIGSGVLSLAWAIAQLGWVAGPAVLMAFSFITYFTSTLLADCYRSPDPVHGKRNYTYMDVVRANLGGRKVQLCGLAQYGNLIGVTIGYTITASISMVAVKRSNCFHKHGHHVKCRTSNNPFMIIFACIQILLSQIPNFHKLSWLSIIAAVMSFAYSSIGLGLSVAKVIAGPHARTTLTGGTVGIDVSASDKVWKTFQAIGDIAFAYAYSTVLVEIQDTLKSPPAENKAMKRATSIGIATTTVFYVLCGCVGYAAFGNDAPGNFLTGFGFYEPFWLVDLANICIAIHLIGAYQVFCQPIFGFVESQCAKRWPESKFINSEHAVNLPFHGAYCFNSFRLVWRTAYVVMTAILAMLFPFFNDFLGLLGAASFWPLTVYFPIEMYIARTKMPRFSFTWAWMKILSWACLVISLVSAAAAIQGLATDVKKYKPFQTEQ
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Subcellular Localization:
Mitochondrion. Cytoplasm.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MRLGNAVYLLIPSTKPPSRVYSSNLRRHFLSHFRFSSSSVAVMPGSEPSEIQWPARRVRDTYFDFFKGKGHKFWPSSPVVPHNDPTLLFANAGTADPNTELSKLTRACNTQKCIRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKEAIEWAWELLTKVYGLPTDRIYATYFGGDEKAGLQPDNEARDIWLKFLPPGRVLPFGCKDNFWEMGDTGPCGPCTEIHYDRVGNRDAASLVNNDDPTCLEIWNLVFIQFNRESDGSLKPLPAKHVDTGMGFERLTSVLQNKMSNYDTDVFMPIFDDIQKATGARPYSGKVGLEDVDIVDMAYRVVADHIRTLSFAIADGSRPGNEGREYVLRRILRRAVRYGKEILKAEEGFFNGLVSSVIRVMGDTFTELKEHEKKITEIIKEEEASFCKTLAKGIEKFRKAGQAVQGNTLSGEDAFVLWDTFGFPLDLTQLMAEERGLLVDVDGFNKAMEEARERSRSAQNKQAGGAIVMDADATSTLHKTGVLATDDSSKYIWFQDHESEVKAIYTGSAFLESSAAGDNVGIVLASTSFYAEQGGQIFDTGLIEGSFGTFNVCNVQIFGGFVLHIGYLSKETGEVSVGDKVTCKVDYERRKLIAPNHTCTHMLNFALKEVLGDHIDQKGSIVLPEKLRFDFSHGKPVDPEDLRKIESIVNKQIKDELDVFSKEAVLSEAKRIKGLRAVFGEVYPDPVRVVSIGRQVEDLLADPENDEWSSLSSEFCGGTHITNTREAKAFALLSEEGIAKGIRRVTAVTTECAFDALNEASSLEKEVEDASKAEGNALEKKVAALKSRVDSAIIPAAKKADIRAKIALLQNEVRKAQKKIAEQNLKKSVKVATEAAESAASDGKTFCIIQLDVGLDAAAVREAVSKGMSIMVFSTDETTNKAVVCAGVPDKSDKFKQLDVTEWLTTALGPLKGRCGKGKSGLASGQGTDASQVKAALDLAASFASMKLN
The following text describes a protein:
Function:
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Sequence:
MRSDSIKKGLERTPHRALLFATGIPKSEMNKPFIGVATSFTDIIPGHISMKELERFIEKGIHTGGGYPFFFGIPGICDGIAMGHKGMKYSLPSRELIADIIECIVEAHQFDGIVLLTNCDKITPGMLMAAARLDIPAIVLTAGPMLAGYYKGQRRNLTSDTFEAIGKFKKGVLTEKDLEALELCACPGAGSCQGMYTANTMACVTEALGMSLPGTAATPAVMSEKRRLAFETGVKIVELVRKKINARQILTKEAFYNAIAVDMALGGSTNTVLHIKAIANEAGINLPLEVFDEISRKTPHLVNIIPSGEHYMEDLYKAGGIPAVLKRLKDKIYSNPTVSGIDIKEIAQKAEIYDENVIRSIKKAYHKEGGVAILKGNLAPDGAVVKQTAVSSKMLKFEGIARCFDSEENAMKAILDGKIKEGDVIIIRYEGPSGGPGMREMLSPTSAITGMGLNESVALITDGRFSGGTRGPCIGHVSPEAARGGPIAIVKDGDKILIDIPKRKIEILISESEIKKRLKNWKPPKQKIEKGYLLRYARNVSSADKGAILE
The following text describes a protein:
Function:
Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MQILYFCAVCCINNNSEVSAVKMAASLLRVGRLGSLRCIQTESWSSFSRAPHAAAFSSKSGDNKKSKKSNKEKAASKTYFDIEKLIQHKSFVEFPKKEVAASVAAASTEASAAAPAPEPVLTATAAQTAAPAPEAISPVEAISPVEAISPVEAISPVAEEIAAAAPVVEAAAPVVEAATPVEAATPVVEAAAPVEAAAPVVEAATPVEAAAPVVEAAAPVVEASAPVEADAPVVEAAAPVEADAPVVETAAPVETDAPVVEAAVQVEAQVEATAPVEAQVKATAPVEAQVEATAPVEAAAPVEAAAPVEAQVEAAAPVEAATPVEASAFAVEATPVDEAPVSEAVVEAVSEEVAEAVAEAAPVAEAIIEVVAEAAPIEPVAVAAPSEELVDSAPVITDAAEAPTEVVETPEAGLDPIQKLFLDSIRAYSSQTGAAGGLVDAGPEYQKALAEEIAKLQRLYGGGDLSSFPEFKFPEPKFDDVSAK
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MSAPKPSEKEQKQENDEKQEKQAANSDEEQPLKPKKTRKSYKFDVNFLMDEDIGLTKLYKHLQSFDPNLYPDQPEEALEKILIIYKKWMHRLYPSDFDETARRIAKAPSAKRIVREFIYEVNGGDPYIYDEGDEFGEVLFPSLHKRATNEENPAPVEEEPKQNPPPESTTPKEKATNFLSDQESDNGDAGDSQDIPDILDLFSSQRN