lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATTSTKSTAQVIYKVHPLVPLNISEHWTRNKGQTKRTDNVFGIVMGVQNGREIEVHNSFPVPCEERGGKLFVDEEHYTQRVEQYKTVFPELDTLGWYCTGPQYELSPLEGSLHLELCKFIESPIVCRIITGADFPPQKVPLVIFESSLNEPSKYETLRPVDWTLVSEESERIGVDHVTRHSQANSADNECEVSKQIRSTTSAALMLKKRIHVIREYLNAVNEQKLPGNAEILKEAKKIIEQLPLMESKDLEEHLKSEDKDVNCALLIPDMVKLCGSLQHLVNTMGVMATERSSSLGPQSFKSKLSKMGNAPDLIFM
The following text describes a protein:
Function:
Component of the nuclear pore complex. Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope. In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad. Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells. Has a role in female fertility including egg chamber development; in nurse cells, has a role in the organization of F-actin in subcortical and cytoplasmic actin filaments important for the transfer of cytoplasm from nurse cells to the growing oocytes. Has a role in male spermatogenesis and fertility. Has a role in germ line cell proliferation.
Subcellular Localization:
Nucleus, nuclear pore complex. Chromosome. Nucleus. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Increased localization to chromatin before interphase. Distributed along filamentous structures that extend radially on the nuclear side of the pore complex.
Sequence:
MTLPQAQLDFFTTATSMLEWHYNLERNKPGLLELTGVSQHGRATMSGLNDYDYQSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHFKHIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKYLLVLTTPIEVIVLGVTFGESSYNEMQLMNRPVFVIGTDNVSISVIKGTDDGRIFLGGRDGCLYEIYYQAESSWFGKRCKKINLSQGLVSYMVPSFLKVFSEVDPIEHIEIDNSRKLLYVLTEKGVIEAWDISTSYTTARRLGRITQNDITNQAVSLITTVDPSIFKSVKAICPLSADDADKLHLVAVTQCGVRLFFSTTSLNVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLPPGYTPNATTNKPKQVHAAHYTEGTMLMITTQQHEQDLLWSLSSAPSVNFTYLVESTALESLDGVVWGLAEVHEPSTPQRKSPLNSARHARKVALLTNQGTHIIEVLKMVDVLRQILLSCNGPHHEEVKMFFQSQNQREACVTALLLATSDTYRGSDVALWAAQAFMLYGGEPCYQHQKFLNASNRNMANQTLGPNTTNVRERQSMFMSTPMPNSVANSPVGFPGSQFNQPISPIGNMQPPQVAVSNENSPIVFSAKHDGLYMYVSRMLHSVWQMRCVNEQFCSNLSQSECALLLSDLRSLRSFLEVHSVHDISSTTRVSFDNHLDRTNSYNTIMMGNTLLPIPEQRVLSEQAQVEETRSLSALNLFVKHACEVISLWNILNSHSFQLICVQLSPEHQKLLTCSTFRDLLITRSEVCAFLIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAKNCTSATEKEHMLRTTLHMCKEAAPTLPLHSICMQFISADFFEGVIELSAVCASKSDPEEVGVHFYNNGEPADDREGYTCFATRMAYYKEVQLMLDHIYQRVCNKTHVQDKSINPLKGTAKASDAKNGATQTIPKIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPSLGEFLRRSVSQNVDNVVLIDLLWKYYEKNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMCMRNGNVGSSLSNGIFLKELEDKLDIARVQKSVLAAMTELASDKLEAATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNCSHHNDPLLIESVWGQIINSVVDKPGTTSERCNRLFTKIEILVREYGESGVCFPFAFLIRELEVKACQLRFPEGIVPEKLVSMNLDIELLLEYYSRMISMNERVWANEGNEWHLIQSVIRVVSLLADNAQSIWYRSKRRIVGKAQDIVAGCLNICYQKPDTNRLQHSLKELQSQLQRLLI
The following text describes a protein:
Function:
Probable methyltransferase that may target bulky nonpolar molecules with aromatic rings.
Domain:
Consists of two domains which are linked by a long alpha-helix. The N-terminal domain is essential for dimerization and the C-terminal domain has the class I MTase fold.
Sequence:
MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK
The following text describes a protein:
Function:
Transcription factor which binds the 5'-[TC][AC]TG[AT]AC[AG]-3' motif. During the mosquito vector stage, plays an essential role in the zygote for de novo transcription of genes required for ookinete formation.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The AP2 domain contains a non-canonical linker peptide between the second and third sheets.
Sequence:
MNSKKIEELDKTTNHLDNSRNNMYSCTFMEKGDEDNILNSTILKMNNTEKGISFQTIEEEIKDKNKISNIPSDYAEKEKYCFNELLYTKQNGYINIIEKEDKPIQEILTDDKKNISEIDSSKSDKMDPCLSSQKVDEEYKYGDNYNINGDNPVHNSDEINEDSKCECSFFISKCDYEKDSDANTNGPKKSCKDSEENINYYNNNLLLGISENKDTLIKCDKIFERSYYSTSASTVLASNENEQNLQNISSYETVSSMNEKIKLDGNGKYEKLEKEQTYIMNKETNVINPQDYSIHDIGTYRDECISYLNKIKDIPHNIGSQINSYQNNNIIGNNNFKDKSYLIHENDFFDVETKKKNILQNYFLVNNNNEINANEDMNNRSDDLKNIEAVASDLNEIIEEDTIQKKINISKNCKIEENINMNINDHNKNAVFNFNINRQLFHDNQGDENMYKTNFNTENNKSINIINGMSKEVYEQNSGDIHAQVENINNIEQTTNNIIENNMMIIQGSDDLRFTTLNCINDNSNTDIMKCKRKIKNDENRENIMIKTDQKNIKMKDELDEDDKDELYGIPDKKRRKKNKKKKIPGRVYKVIVRGKECWRAEWLVQKNQENIEREKEESKMDRYSIMKLENTKDVDKNINKMNTPNFQKKSKQFSVSVYGYENARLFALFELIKYNSVPDSLKEEASICIHNIKRNIMNSENSSNKSFSGHFLQFLLADENNEYSSLLYKRLEDNVIQNVNKYSMHEMNNINRMNLFQTQGKEIGFRNEKYFTVQYDNENGHGNNIVDGTIWNIQNNERNLFYNNNNKCRNDYYYNNSNDIIKMKKENNEKLTTFNDNNFYNKANYINRYNNPYVSNNNPSIHNLNNLVYNINSYDFNPMHIRNGYGNDSNSTINISSPNSNYHRGFGEEKDIQKKKNFFNINNTRKYVGDINNKPMDGFKQNLFEKVLNNLENNMGNNNLYNYNSLEHHINSKVKSTYPYNNDNITNDPANTTTMISHGANNNQISNETEIRNSQQILHDNLLVYRNFMNPSSCDIGNVDKNSENDRGEKMASNFEGAFLNKSNIVFKQNANFDPFLGRNVSNINT
The following text describes a protein:
Function:
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Subcellular Localization:
Secreted.
Sequence:
MKVLIVLLLGLAFVLADHHHHHHDYVVKTHEDLTNYRTQCVEKVHASEELVEKYKKWQYPDDAVTHCYLECIFQKFGFYDTEHGFDVHKIHIQLAGPGVEVHESDEVHQKIAHCAETHSKEGDSCSKAYHAGMCFMNSNLQLVQHSVKV
The following text describes a protein:
Function:
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus.
Sequence:
MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQTPKSTAKWASSLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKTQDKKQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEDEESPDAQTAAKRASRIYNT
The following text describes a protein:
Function:
Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
Sequence:
MILIKIGGSVFSDKRGEPENFRTDVVEEIARELAEFYPDEKFVIVHGGGSFGHHYAKEYSIREGLSGSWGIDSWRRLGFSLTHQSMLRANSKFVEIFTDHNLPGFSISTSSLFITERGEILYADIEVIEKLLELDFIPILFGDVSVDVAQGIDILSGDQIMAYLTKMLKPKKAIFLMDVDGIYDGKPGEGTLIPELAREEVPALLERLHCTAAGTDVTGGICNKLRKAYEMAHYSEVWFVNGKVPGRLSGAIRGDGFGTRLR
The following text describes a protein:
Function:
This promotes the activity of RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSDPPTPLTLPPTLPYPITLTRLVARPGDKIKRGSRLLEYTFMSSDLKEKVAKRRLQGGGMGEIENEKEKDDLSGTWESLIDGDVVEWKGAKPGMIVERNQASQIIVTVQQACSHPVQLHGLCGVCGADLTEDDYLSRPVSNQTQAGPSRYPGGFEIAHDAMGVTVSKNEAQRLENLTRDALLSTRRLSLIVDLDQTIIHTTVDPTVAEWMDEIHREEMKDAQEKANVPTEEVKGKGEETTTPPGSPGPGALGITVESPKEKNPNAEALRDVAKFQIADDLPPGYVKLKTKTTKGQNPPESEGRWYFTKPRPGLQRFLDEMCQLYEMHVYTMGTRTYADAIVKVIDPDGKIFGGRILSRDESGSFSSKNLKRLFPTDTSMVVVIDDRSDVWGDCPNLVKVVPYDFFLGIGDINSSFLPTNKSTPPPSAATTAATTAAAASSSSAPLSPSLSTSPSPPPTLPPSPPSASSNASTPPPVTPSEVSADLEPIERVEPVEPTREEELMMQAKLLDQLSTSRPLARLQEELEKEDSEDDESGEGQGGEAAVAAEAETGMKKVTGKEEEKEKEHEEKAVASVRDDSRKERSKSPNKHRKPLLNPNDYELVRVANILQEIHSRFYKAFDAIDGWDPKKALPMSCDVEFIIPEMKAEVLDGCNLVFSGMIPREANPSTTAIWQTAESFGALITPSLTPRTTHLVTALLNTEKTWRAGKMEGVKVVWAEWFWDSVALWERQDEEKYIAGKKEGTGDAGKGVGPEGEAGNSDNHKDLKEEDEDGEEHEDMNDDTQVGQGWDEEAEREWEEFMAGEDDWSDGEGSVGSRKSVKGESAPSTPSKKRVRYADEELLPLEEFKDPSPTASSDAPPSKRHKAYLIEDTTSGEERSEESRSQHKDHWTYEADVEKHDEKAGDEDDGRSVAESMEGAEGDDEFALLLMDSLANDDADGDENRDGDSVVAGEK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.
Sequence:
MYKRACCAAFFYFPVVFVCILLFRYTKLFLPLSQSTAFFRINFSPPYCSALEAVAAATSAWALRWQMQPVRTSVRNFIASGFPSKKLRYARLVDVEECASRPQFQKLLQSYLSDFFAKSHENGSTGSSPWFTAVPPSLRNSVEETVNYLGMLVAIDFRHWGEDPPDATPTGSRVENICGFYAELPEGSAETSGSVSYGGKRLIRGSMAMVHLLCRAVEVYHLNWHCPQFLQQFATTEDAMEALERCFLGYREDGHTSMWMPAARERVELLLSLSRSLVEKDTSFFKMLCLSEGYLYHPIFPHLGFVEMLVELHPRYYDVCVLRGEVGGGKDSDQGDEIVIPMLKLAQLTVMAIEEAVSAMDTVAANTPNVTEAPFPFSGAHGVFKDKHHLTVCCDYQLPKALRSLGLVEYDSYLASLVDTGVLLAAGGVEECCIRVAALVASDLLLDYLRSSCACTTGREWRPESTSRVWDAPALDCMLWWIGRHYVDSAVKHHLCRTIMY
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Miscellaneous:
MISCELLANEOUS: In plastids the F-type ATPase is also known as CF(1)CF(0).
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Sequence:
MSLQISILTPERPFWNGQADEIILPTETGEMGVLKNHAPIITGLNVGAMLIRGGQASGSKDEWNSYAIMGGFALVKQNQVTILANEAVSAENINPEEAKDAFETAKANLEKAEGVKEKVEANFAYKRAKARYQVVKVLKKI
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATPNTERKSPSTQLVVIFLLWKTLLHVLTTFCPGPGYDTSALILVEPSVKRHVNFSVASWSDRLALNLFRWDSLYFIKAAERGKYHEQEWAFSWAYSWLLDYVGQCTVDIQMDLNGGSKPALRQYLMTGIVVSNVCHLLSVLALYQLLTITVDPRRKHRVAFIGAVLHVMNPASLFLSSPYAEAPFSLLNITGMLLYTRSRIRAQTQQPSLREDAYKLGSGIFFGFATLMRGNGLLSGLILLYDVARYLPRVFSMRLTLHDMRRIVVTCVAGSVVALGFIWPQYLAYTEYCTGDRSVGSPPWCKKTIPSIYSWVQSHYCGTVLCSPLKPLLHGRPVPQHGATSDPIETSATAHYVPELALPQFVLAVAAIVSFHVQIVNRLASGYPTWYLMVATWLVDDSATSGCSKPQRQSRWIVRGMISYAIAQGMLFANFLPPA
The following text describes a protein:
Function:
Involved in the biosynthesis of sitosterol and campesterol, a precursor of growth-promoting brassinosteroids.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MAADNAYLMQFVDETSFYNRIVLSHLLPANLWEPLPHFLQTWLRNYLAGTLLYFISGFLWCFYIYYLKINVYLPKDAIPTIKAMRLQMFVAMKAMPWYTLLPTVSESMIERGWTKCFASIGEFGWILYFVYIAIYLVFVEFGIYWMHRELHDIKPLYKYLHATHHIYNKQNTLSPFAGLAFHPVDGILQAVPHVIALFIVPIHFTTHIGLLFMEAIWTANIHDCIHGNIWPVMGAGYHTIHHTTYKHNYGHYTIWMDWMFGSLRDPLLEEDDNKDSFKKAE
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Sequence:
MLMYYSLFLFNLIICCNVTSIYGYIHNVRSLEPYIKNDQIKNYSSNIKQKRKGSLYLLKNEKDEIKIVKYPDPILRRRSEEVTNFDDNLKRVVRKMFDIMYESKGIGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQSLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHLKILKGIHSRIFQHEFDHLNGTLFIDKMTQVDKKKVRPKLNELIRDYKATHSEEPAL
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MACRDLPLQTIYKISENLCMFPAYNFAKSQIEKARFRKIQGCLIIFIIILAIIVSLYMRHYHFKGLFTPTHLTLDNLNELFLTGVALGLVIRTCFGKTDHWFQLQYNLQTLDKILGNCSEDGNFWKNIYVQLILYGLIFVYGIYYMVLMMVVEKVGSWMDFVYVVHEFCYLYDILVHFLFINIASNLHTKYKSMNRLFNFAKTTDSFRKLGTISRVLAETVHAFNTTFGWVFLLIIAKNVNQILRCLNYILNNTFNLSISNTILGIYISLTLASIMLSCDFVVTESRKSVFLCFKLQEQFESLVDRNELFNLGKQLEANTVTFTAAGFFEINRSALFAIFGTVATYSLVLVQFNGDFANQQNCTCLQ
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MPFEEELFLRTIYERARSIYCSRAIMTTSDGVWLNDNPFHFSLPILLFQLTVIFVVCKLTHAVLRRLGQPLIISQIMVPVTAGIIVGPDMLSRNLKFQYLIYEPQSYEQLSIVGIFGCIMYFFVVGVKADLGLIPKVGKKPVAIALFCTLLPVVSVYITATALRHKIPPPNSTSSAPSSAASCINTYVLSVKIGSPLRALEALSCLAALVVIIMFVLRPLVLWLIRRTPEGALLDEASFVAVLLMAFVCALLAGIIGYDVFTGPFFFGLVLPGGAPLGATLVERMDRMVMGLFLPVAIVQAGTRMRMLLLTDTLRWGLFELFLVICVVSKFLGVILPCLYCKMPHRDTVSLALMMTTKGIYEIVAATLWQDDRVRFLQHPPPPAAD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
Subcellular Localization:
Cytoplasm.
Sequence:
MKALLLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGCPDGCASLTATTLSPEVSAAATISLMTDEPGLDNPAYMSSVEDGEPVTNPSDTGRSNRTRARPFERSTMRSRSFKKINRALSALRRTKSGSAVANHADQGRDNSENDTVPEVFPRLFHLIPDGEITSIKINRVDPNESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLRLTVLREQKFRSRSNAPAPDSYGPRDDSFHVILNKSSPEEQLGIKLVRRVDEPGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAAHLIQASERRVHLVVSRQVRQPSPDIFQEAGCISNGQQSPVSGERSTSSKPAATCHEKVVSVQKDPNESLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSTPSSVVLKALEVKEQETQEDCSPAALDSNHNVTPPGDWSPSWVMWLELPQYLYNCKDVILRRNTAGSLGFCIVGGYEEYSGNQPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMMHACLARMLKELKGKITLTIASWPGTFL
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
IPSALPRKFGIPLEFMEFLLSPLSYKEFSEKYWEREPFVAHDRAGMRAFWPQLFSKDAFFSIAKETKLYFGKDVSACKYEDGKRSDYAEGYSAKSAKLNKYFEERKATLQVHQPQRWKDSLWEVLELMERFFGCLVGCNAYITPAGSQGLAPHHDDVFIVQLEGEKCWKLHKPVTELARIYSKDFTSEEIGEPTHEFTLRPGDFLYMPRGTIHHAYVPESADSHSTHITISTYQKQTVGDCLMDIAPDLISSAMDSCIELRKGLPNRFLPSCVLSKETVVTALSSVLEHVKQMPDEMPSPEEMVRDFMFSRLPPFGFDRRNTSMRPYGDVPHLNDRVKLAYPDHCTYLTEYSDEDEEGGFRPEQALSFPYPWASPLRHMKGNAAKNNALLVTSVYNKREEHMMSSSDAQHEEESAIIKLPINLLDGVKQLCESEDFVSVKALEAPCDEDRLFLALALWTRHLLKIQYDAEPE
The following text describes a protein:
Function:
Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter; Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular Localization:
Nucleus.
Sequence:
MGDNPVRKVRKSNFSTDEVDVLVDSVRANYGILYGLNAKRATNRWIRQKAWLDILGRVNGVSVEKRTLQEVKNKWKKCQYALKEKGQGALGDDAGDSPWEDYVGRPARSPAPRSPLLHSPPAAMRRNSRHRRQLYNAYDLDLKKSVVIFAEANGNKEAQARYGISEANIRRWRRLKDDLFGRPRDYDRGNLRVRRRVNYTKTKTEKEEDCSSVDSMPLQERLSKMAAQERIAGQVLKSQPLSPTKLKVTRQAPRALKPPEPPQSPVNEEMCLRWNSHHSNMQTAFPSILSKEQYVDVTLAAEGKTLKCHRLILSSCSPYFEEILSGISPLQHPVLFMKDIPFWILKSLCDFMYAGEVHIFQNKLEELLTVAEALKIKGLAGKSTPPDPQSENKETKKKNSQGKHHSTPIRKHPIYNQNSFESTSQDYDDDLLDPLDLLEPLYEEAAEEKKPAVTKPKENKYQYQPVKKPFGRRLRKRKFSEPQTREPSPPPVFSFRKGTRSRPNVKIPKYYHPDYTNPPKPVISSQTDPLLDVDEIKTEPIDVEDNMIDYSDEDHYMENSLETANCDSPIIITSAKPDKFKKIKLSKPIITEVHSVKETNPPPGGLEVIKLTMPQPEEGDKEEVVPEPEPEQEEPLQNVVIERTEGGVEETEKIVEHEGQVTENGADEEKQDGESEVPVQNIQIESVVSAENGAAFAEEEEEEVKQDGGGEIPVQNLQLENVTSSENGAEEKQDGDNEVPVQVIQIENVRSEQDQEFQEEEERRTASLNHLEKEAMSVADAITMENQTDPPDIEEKV
The following text describes a protein:
Function:
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes.
Miscellaneous:
MISCELLANEOUS: Present with 2660 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MVVNTIYIARHGYRSNWLPEGPYPDPLTGIDSDVPLAEHGVQQAKELAHYLLSLDNQPEAAFASPFYRCLETVQPIAKLLEIPVYLERGIGEWYRPDRKPVIPVPAGYEILSKFFPGVISQEWDSTLTPNEKGETEQEMYMRFKKFWPLFIERVEKEYPNVECILLVTHAASKIALGMSLLGYDNPRMSLNENGDKIRSGSCSLDKYEILKKSYDTIDETDDQTSFTYIPFSDRKWVLTMNGNTEFLSSGEEMNWNFDCVAEAGSDADIKKRQMTKKTSSPIPEADDQTEVETVYISVDIPSGNYKERTEIAKSAILQYSGLETDAPLFRIGNRLYEGSWERLVGTELAFPNAAHVHKKTAGLLSPTEENETTNAGQSKGSSTANDPNIQIQEEDVGLPDSTNTSRDHTGDKEEVQSEKIYRIKERIVLSNVRPM
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MEAALTLAQALGGPANISLDSSQDRDSENGDGMGSGEGGICVVCSDEASGKHYGVMTCNGCKGFFRRSVRAPKPYECRANGNCPIDRMARNGCRACRFKRCLDVGMDTDAIRPDRDKTGKRASQGGPTPSQSSGSLNDVLNAVKRYNTEDAFLDEPLFKKAKEEMLNVPIAPVQAVTMSDHHVLITLKQCDDQVLSMLDMAPPESLSSSSFTLIDAITHPTLLSPRFPMATDSDGVNANCTDIAKNCRRLFCQLVDFINSLRPVADFEVIEKASIAKNVAPSFILYNIVQYSINQDSPGHCLSLPLGQTVSRDASLLESPSEDSKTHVLAEMRVADIKSAVLEQLTNYAKDLDLSDLEQSAVRALIILEANYSVSKPSTALLEAARASIMDALQVYLLTKYSKQESIYRFGNIMLLIGKVQQHATLVLSFLQFAKDNSMPVDPVIDRFLLYPSF
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MEMDGFLSTEEENRACLRNSDIFPSKYKIGKMLGHGTFGTVRFAEHVPTGYGVAIKIINRVKIMKDDNKKNQLWEKVKREMKISKIFSRIAHPHIIRIYEIIETQSDILIVMEYVKSGELFDHIVEKGRLPECNARNFFQQIISGVECFHTNMMVHRDIKPENILLDEKLNAKIADFGFTNILRDGYFLKTSCGSANYAAPELLCSKLYAGPEADIWSCGVTLYALLCGVLPFDDANIPLLYRKIKSGKYMIPCQLSAGAMDIIARMLVVDPEKRITLPMIHQHPWFQIQIPRYLVVLPSPSTMYRSSKIDHSIMEETIKIGFDENHLLDSLHNRIQNQATVSYYLLLDNRSCFSNHYLEAEFQQTMDWNHDGGGYVDVVTGLPERNWTVGIQSTSPPYQIMIEVLRALQELNIVWKRIGDYNMRCRWFSTHPCVPVNEVSHSSSKTAQMEVKFELQLYKTKEKRYLLDIQRLIGTPIVFLDLCGAFLAHCVHHRFLRFEN
The following text describes a protein:
Function:
Removes the 1-phosphate group from lipid A species. Absence of phosphate groups in lipid A renders the bacteria resistant to host-derived cationic antimicrobial peptides (CAMP) and allowing it to camouflage itself from the host innate immune response.
Miscellaneous:
MISCELLANEOUS: When grown in low hemin conditions the major lipid A species are non-phosphorylated tetraacyl and 4'-phosphate pentaacyl lipid A, while under high hemin conditions the major lipid A species are non-phosphorylated tetraacyl and 1-phosphate tetraacyl lipid A (hemin is protoporphyrin IX containing Fe(3+) with a chloride ligand (CHEBI:50385) involved in the change from healthy to diseased gums).
Subcellular Localization:
Periplasm.
Sequence:
MNRESFLLLLVLLFALPLHLQASSPCNNMADTTCISDSAKMFPPAIGVYHVKPMKNTLRHSLPLVAASLLTFNVDDNIRELRFTGAGSFHTKIDNVSQLVPLMAQLSMRGFGYKGRSKSWGKMLVSDALGMALMGGMVNAGKYSFGRLRPDGTAANSYPSGHTATAFACATLFHLEYGSRSPWYSVAGYTVASFTGISRIVNNRHWASDVLCGAAVGILVGELGYWISDLIFRDPTGYNYKLTKKQEGTLESMVISLSTGNRYINRQMDFEGKTVERTDAFGMNLKTTFNPSFARWVRIGLQFSVSTEKQKGLTRERPAKVFVAPAISLGLSAGVEWHPWQRASVWAEILPSILFRTDFTNAQDKPDEMSSKLHRRSSFQPAFQVGVAYRVSDHMGIEAHAGYQLGEAVYHLMEETSTWSIIKKRATVPYRGFEFAVGLQFYPFR
The following text describes a protein:
Function:
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
Miscellaneous:
MISCELLANEOUS: This NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAASFITSLVTRLLRSAQSGRLHQRPFHLSAVRNEAVVISGRKLAEQIKQEVRQEVEEWVASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVGINSETILKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQCSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEELKKHTALADIVISAAGIPNLITADMIKEGAAVIDVGINRIQDPITAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEQEVLKSKELGVASN
The following text describes a protein:
Function:
RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQEDITTERCRQALRKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGNEEDSTAGTTEQPSKEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLRTIRGQQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRVRLTEVQDDKEEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFESQRKGRQQQLPQTLPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLKGEEKDGISDSDSSSSSEEEESWEPVRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPIGKKEMEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK
The following text describes a protein:
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWQGYVDEQLVGTGNITAAVIIGAADGSTWATSKNWTLKGGEGAGIVALYKNPADSFAKGITAGGVKYMAIKADDRSIYGKKGATGIVVVKTTQCIIIGYYDETKQPGNAAVVCEKLGDYLIENGY
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein.
Miscellaneous:
MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVLLISEIKDIAKRLTAAGDRKQYNSIIKLINELVIPENVTQLEEDETEKNLRFLVMSLFQIFRKLFSRGDLTLPSSKKSTLEKEQFVNWCRKVYEAFKTKLLAIISDIPFETSLGLDSLDVYLQLAELESTHFASEKGAPFFPNKTFRKLIIALWSSNMGEIEDVKSSGASENLIIVEFTEKYYTKFADIQYYFQSEFNQLLEDPAYQDLLLKNVGKWLALVNHDKHCSSVDADLEIFVPNPPQAIENESKFKSNFEKNWLSLLNGQLSLQQYKSILLILHKRIIPHFHTPTKLMDFLTDSYNLQSSNKNAGVVPILALNGLFELMKRFNLEYPNFYMKLYQIINPDLMHVKYRARFFRLMDVFLSSTHLSAHLVASFIKKLARLTLESPPSAIVTVIPFIYNLIRKHPNCMIMLHNPAFISNPFQTPDQVANLKTLKENYVDPFDVHESDPELTHALDSSLWELASLMEHYHPNVATLAKIFAQPFKKLSYNMEDFLDWNYDSLLNAESSRKLKTLPTLEFEAFTNVFDNEDGDSEASSQGNVYLPGVAW