lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 175 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS.
Subcellular Localization:
Cytoplasm. Cell membrane; Single-pass type I membrane protein.
Domain:
Recognizes phosphatidyl serine via its epidermal growth factor-like domains.
Sequence:
SLPSLLTRLEQMPDYSIFRGYIIHYNLASAIESADAYTVFVPNNEAIENYIREKKATSLKEDILRYHVVLGEKLLKNDLHNGMHRETMLGFSYLLAFFLRNDQLYVNEAPINYTNVATDKGVIHGLEKVLEIQKNRCDNNDTIIVRGECGKCSQQAPCPLETKPLRETRKCIYSIYFMGKRSVFIGCQPQCVRTIITRACCAGFFGPQCQACPGRGQNVCSGNGFCLDGVNGTGTCQCGLGFNGTACETCTEGKYGIHCDQACSCVHGRCSQGPLGDGSCDCDVGWRGVKCDMEITTDNCNGTCHTSANCLLDPDGKASCKCAAGFRGNGTVCTAINACETSNGGCSTKADCKRTTPGNRVCVCKAGYTGDGIVCLEINPCLENHGGCDRNAECTQTGPNQAVCNCLPKYTGDGKVCSLINVCLTNNGGCSPFAFCNYTEQDQRICTCKPDYTGDGIVCRGSIYGELPKNPSTSQYFFQLQEHAVRELAGPGPFTVFAPLSSSFNHEPRIKDWDQQGLMSQVLRYHVVGCQQLLLDNLKVTTSATTLQGEPVSISVSQDTVFINNEAKVLSSDIISTNGVIHVIDKLLSPKNLLITPKDALGRVLQNLTTVAANHGYTKFSKLIQDSGLLSVITDSIHTPVTVFWPTDKALEALPPEQQDFLFNQDNKDKLKSYLKFHVIRDSKALASDLPRSASWKTLQGSELSVRCGTGSDIGELFLNEQMCRFIHRGLLFDVGVAYGIDCLLMNPTLGGRCDTFTTFDIPGECGSCIFTPKCPLKSKPKGVKKKCIYNPLPFRRNVEGCQNLCTVVIQTPRCCHGYFMPDCQACPGGPDTPCNNRGMCRDLYTPMGQCLCHTGFNGTACELCWHGRFGPDCQPRSCSEHGQCDEGITGSGECLCETGWTAASCDTPTAVFAVCTPACSVHATCTENNTCVCNLNYEGDGITCTVVDFCKQNNGGCAKVAKCSQKGTQVSCSCKKGYKGDGYSCIEIDPCADGVNGGCHEHATCRMTGPGKHKCECKSHYVGDGVDCEPEQLPLDRCLQDNGQCHPDASCADLYFQDTTVGVFHLRSPLGQYKLTFDKAKEACAKEAATIATYNQLSYAQKAKYHLCSAGWLESGRVAYPTTYASQKCGANVVGIVDYGSRANKSEMWDVFCYRMKDVNCTCKAGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAFSKSSARGQAFLKHLTDLSIRGTLFVPQNSGLPGNKSLSGRDIEHHLTNVNVSFYNDLVNGTFLRTMLGSQLLITFSQDQLHQETRFVDGRSILQWDIIAANGILHIISEPLRAPPTAATAAHSGLGTGIFCAVVLVTGAIALAAYSYFRLKQRTTGFQRFDQKRTLMSWLLASSSPRISQTLCMRPQRRHPQSPPVTPSQTLENRIWRTATLWGHCGPDMRSQQATTVTVPR
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
Subcellular Localization:
Cell junction. Cell projection. Cytoplasm, cytoskeleton.
Sequence:
MGENRGPNPVQTLFPIQKVQTLKSGWLKKRRNIMKNWQHRWFVLRGQELRYYKDKEEGKLQGCIPLLGFQVLEVNSQSEETNRYLFEIVPGDKVTVNHETFLLMANSHHEMEDWVRAIRKVIWAPFGGAVFGQRLEEAVNLETSHAPLVVEQCVDFIRENGLQEEGLFRLPGQATLVKELQDAFDSGAKPTFDKNTDVHTVASLLKLYLRELPEPVIPFSRYQDFLRCAHTLSRDQEEGTQEICILIKGLPPVNYNLLKYICSFLDEVQSHSDTNKMSVQNLATVFAPNILRPKLQDPIALIEGASLIQHLMTILIRENQRIFQAVSSDSPARESVQQIDTTQCIQDAGTAKFQSLEPILYGNHEQTRAKSQIFANWKASFMLSSSKSVFSSCDSSNQPPSGSWLQNGFSSLRSQREKDSAKAQRLSSYDNVPSCLPSLPSSNWSSFSNVSLNDSLASCQACDGSQVSQGSGSAWHLSLSESERRTLPLASSIERLELCVSSSGQSDTTLTSDSGEVWNTCHRMVTELKEQLAKQQVEYENKMTSLERSRAEVLVQVRSLQDKLEQEKNRCTLLEIKLRNSERGREDAEFRNTVLQKEMEEFFQTLGNLSQNRTSKYPNKDYI
The following text describes a protein:
Function:
Catalyzes the hydrolysis of alpha-D-mannosyl-glycerate (MG) to D-glycerate and D-mannose. Can also hydrolyze alpha-D-glucopyranosyl-glycerate (GG)with lower efficiency.
Sequence:
MAGPVRCLPPVVEATSIPHAPPVISKEVSEIVNNMLSVAIPAAAAASAQDQRFASQFRCGPEFATMKAQALEACRKILAENDQGGYTIPAKGLYPYQWNWDSALVSLGLAEMEEERAWEELDRLMSAQWEDGMVPHIVFHKPSSTYFPGPEIWGSPDKPRNSTGITQPPVAAISVRRLLEEAKDKALALAMARKLFPKLLAWHRWFYRARDPEGTGLVATIHPWETGMDNSPAWDEALARVPIDDIPPYVRRDLGHVDAKMRPQKAEYDRYLTLLYRFRALDYDEAKLYYETPFRVTDLCTNCILHKANEDLLWLAGATGACTDESEIRGWTARANVAFDTLFDVEAGLYRCKDQLTGQFLPAATSAGFLPLFAGVASGEKASAVARTLGRWLDDVAYGIPSCDPRDPWFEALRYWRGPVWLIVNWMVSEGLKRYGYGELAQRVERDSYELVKNGGIFEYYCPLTGMGAGGGCFSWTAAMCLAWLFKS
The following text describes a protein:
Function:
Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNIFDRKINFDALFKFSHITPSTQQHLKKVYASFALCMFVAAAGSYVHVVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSVGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAENGDQDYIWHCIDLFLDFVTLFRKLMMILAMNEKDKKKEKK
The following text describes a protein:
Function:
Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs.
Subcellular Localization:
Rough endoplasmic reticulum.
Sequence:
MGQFMKPGKVVLVLAGGYAGRKAVIVKSNDDGTSDSPFSRALVAGIDRYPLKVTAAMGKKKISKRSKIKSFVKVYNYNHLMATRYSDVFRDPALKRKAPQEAKVKFEERYKTGKNKSFFQKLRF
The following text describes a protein:
Function:
Galactose- and N-acetylgalactosamine-binding lectin. May play a role in cell-substratum adhesion rather than in cell-cell adhesion. May be necessary for the maintenance of normal elongate morphology during aggregation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTQGLVQLLANAQCHLRTSTNYNGVHTQFNSALNYKNNGTNTIDGSEAWCSSIVDTNQYIVAGCEVPRTFMCVALQGRGDADQWVTSYKIRYSLDNVSWFEYRNGAAVTGVTDRNTVVNHFFDTPIRARSIAIHPLTWNGHISLRCEFYTQPVQSSVTQVGADIYTGDNCALNTGSGKREVVVPVKFQFEFATLPKVALNFDQIDCTDATNQTRIGVQPRNITTKGFDCVFYTWNENKVYSLRADYIATALE
The following text describes a protein:
Function:
Suppresses activation of the host plasma kallikrein-kinin system, leading to inhibition of the intrinsic coagulation pathway. Blocks host coagulation factor XII (F12) and prekallikrein (KLKB1) reciprocal activation without affecting their amidolytic activities. Blocks binding of host F12 and high molecular weight kininogen (KNG1) to negatively charged surfaces. Attenuates generation of bradykinin by interfering with activation of host kallikrein-kinin system.
Subcellular Localization:
Secreted.
Sequence:
MKTILAVIFFGILAFAFADYPSIENCTHPPAMANFNQKKFLEGKWYVTKAKHGSNSTVCREYRAKTKGNDQILVGDGYYSFNGGTFYFTVRCKRLPNKEVQKPLQFTCTQKSTDDPSKMFKFQLEVTILDTDYANYAVMYRCVQFPEQLGSHFEDNTLLLHRNPDQLVDENQVERKLNLSFDSFRSREDVVDGCPKLPSKKKNKAS
The following text describes a protein:
Function:
Inhibits voltage-gated sodium channels (Nav).
Subcellular Localization:
Secreted.
Domain:
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
Sequence:
MSIFPIVLALLLIGLEETEALDGYPLSKINNCKIYCPDDDVCKWTCKHRAGATNGKGDCIWYGCYCYDVAPGTKMYPGSSPCYA
The following text describes a protein:
Function:
Catalyzes a step in lysosomal heparan sulfate degradation.
Subcellular Localization:
Lysosome.
Sequence:
MSCPVPACCALLLVLGLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNEL
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDTLVEELKDKVVITDEEVDVSDVEEKFRVPKPAGYDTIVVIQGAPVVDESKKKDFFRFLTTRVFAKIGKVKENGLYMPFNDVNGTSKSMGLVFADFENVDAADLCVQELDAKRIDKSHVFAVRKLNQLEKAFNTPEEFHFEEGEYHEREHLRSWLADYYGRDQFISYAGNTVTVNWNRKSDVPEQVVSRENWTETYVQWSPLGTYLVSLHLRGIQLWGGASWKMCARFLHPYVKFVDFSPSEKYLVSYSYEVVKLPPIGHPARETMPFSDADEGKNCFIWDVQSGRILRSFKIAPGGDVKDPKKVVWPIFKWSANDKYLARMTPGQSISVYETPSMALVDKKVMKIEGVQSFEWCPVDDVVADKSEQLLAYWTPELQNQPARVALVSIPSKATVRTKNLFNVSDCKLYWQSHGDYMCVKVDRHTKTKKSTFSNLEIFRVREKNTPVEVIDLKEVVLNFAWEPKSDRFAIFSANDQSLGSPNLKTNLSFYGLEKKKNTPSVFRHIATFEKKSLNSLFMNPKGRFLAAATLGSSTQYDLEFYDMDFESEKKENENLANIQLIGSAEHFGMTDIEWDPSGRYLTTSSTIWRHKLENGYRICDFKGTTLREELVNDFKQFIWRPRPPSPLTKEEMKKVRKQLKEYNRLFDEEDIAEKSSANRELAARRRRLIDDWEAYRQKVTAQVAEERKALGQTGVADAASAEEVIEETIEEVVSEEIIPVDE
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MRCISCREEYLPRNAGTCKECYVEAGETEEELKREIDDLKAKVAFLRLSSSLDHGTSSTSRSFTDVVLIASEDNAGSPPIPAHKSVLVSRSPVFKAMLENEMEESLSGTIKISDVSYDALRTFVYYLYTAEACLDEQMACDLLVMSEKYQVKHLKSYCERFLVTKLSPDNSLMTYAFAHQHNAKHVLDAALSQIVENMDKLTKREEYMELVEKDPRLIVEIYEAYLSKQVNTAAGGTSTSKTS
The following text describes a protein:
Function:
Essential glycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin. Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MTTQNTTPAGFTGNRNRYYNPVSKIQSLIHNLDAELVQLCKQCSVQKPLTSLNNSTSLGSHFSNFGALGGGSGSKTMGGSSSMGSNNFSPDSIGNLLARVRASTPLPRTVTSSPTAPEAQKRQMRNVYRTRVIDAYRNRRIFTVYGNYHTVRRALMRRGWLEKLPASRHAKLQSMSEDALLEHARRGNDYEAVVISKMINHFPAFFIWQGKGQRDLCAEVRPFRNRVRRSQFLDFSTKVGLVGCAEQERWYREDGVCGMSYPRFYRLGGNNLEERMAFIEDYQQTQARSLLLYVREHQPAELISENGTIFSTTLDFALGKVKKMVRHAEHYSLDDARIKPPTPAEIVENQTFMVQSTDVLKSNAKFKVSEKVMAEYARLAGLYLDQIESLRPDYRWDGSRNLWILKPGYQSRGIGIVIRSSLDDILQWTSNNQNKKYIVQKYIERPLLIYRTKFDIRQYMLLTITDTKVSIWTYRDCYLRFSSQEFTMDDLRESIHLTNNSVQKRYKNKTNRDSRLPKNNMWSLDQFKNYLRIMGAPDGSWSKTYNGFKQNLVAVVMASLDETELLQNAFELYGCDFMLDEHYNPILIEINSTPDLSPSTEITARICPMVLKDCIRVVVDLPKNPTAATGLFELAFEVNYSINKGADGKPLELNGKQMTLFENMPRMRNSPRTRLLRKILNNVKTSTTKKVEKVVEAPAKNVKNPTAKITKKKKLSASAGSSTAASAQPSTQNLTTKLILNPATRENLALQYTAPK
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Required for proper proteasome assembly.
Subcellular Localization:
Nucleus.
Sequence:
MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFKKHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGKIYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVETYGSFDLKEKVAFILDQVRLFLLRSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYDTAVVQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRSNPVFAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQNVQEQLNEWGSNITELLGKLEKVRQLIIKEEMMNSIQQAVAK
The following text describes a protein:
Function:
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Sequence:
MVGFMGDELFKEFKEHSVAEFFRKNKHMLGYSGKIRSLTTIIHELVTNSLDACEEAGILPDIKVEIEKLGADHYKVAVEDNGPGIPLEFIPKVFGKMLAGSKMHRFIQSRGQQGIGAAGVLLFSQITTGKPLKIITSTGDGNIYEVEVKMNVEKNEGEIVSKKVRKGKWRGTRVEGEFKEVSYNRGEFGPFEYLRRISLATPHAKIVLKDPYGEVVFDRVVNELPKKPEEMKPHPYGLTTDELLYIARKTKSKKVSSMLVSELSRVTTKRIKELINYMLRDLILKKFKDSVFWNMVVSCYLNIDIESYLNKFKDYITDDEIETVRMLIKNLPESLDELKRYALKYITMEYLFNKLSEEEINKLKNHFKKIPENFMEWAEKNYLSATVVDELNKKVKNIVKNPEEFIAEIKNKGLISDEELKKFEDEVKSILNKNPKELTWDEAEMIVNCLQSMEFMAPPTTGLRPIGAENIEKSLKELLQPDFVKAITRNPKTYKGGIPFAVEVAIAYGGNAGRQGDEGRRMEIMRFANHVPLLYDASACGLTKAVKSINWKRYGLRGEDAPITVFVNLISTFIPYTSAGKQAVACSENENEEIYNEIRHALMICGRELEKYLSRIRREAEEEKKRKYVMKYARIFAEALANILNKPVDEIEEKVVKLLE
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLPSPNNLSGLNQNILEELLRDKRSPNTRRTYAKALKDFFLTMAGEEPSPDVIAWFLSLDHFQAIAMVLRYRAELLAKDLKPATINVRLAAIKSLVNYARRVGKCQYTLEDVEGLKAETYRDTTGVSPTSFKQITDHITPDSLKGKRDLAIMRLLWDNALRRAEVCGLNVGDYQPTERQLLIKGKGKLGKQAITLSAKGMALINQWLTAIGPRPKNEPLFCTLDRATFGHRLSGNAIYNLVRTSAESAGIHKVMSPHRVRHSAITAALEATNGDTRKVQKLSRHSNLNTLMIYDDNRHQHQAQITDILADLL
The following text describes a protein:
Function:
Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex.
Subcellular Localization:
Cytoplasm. Nucleus speckle.
Sequence:
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQRMHVDPVGWILTTECFQVPQQKAMAPLHPHPAGMRINVVNNHQAKQNLYDLDEDDDGIASVPTKQMKFAASGGFLHHMAGLSSSKLSMSKALPLTKVVQNDAYTAPALPSSIRTKALTNMSRTLVNKEEPPKELPAAEPVLSPLEGTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLDGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPDTILKALFKSSGASVTTQPTEFKIKL
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MATIRTLTLNLLIILCLYLPIPNNPLVLGDVEETLKRIQSHKGVIGIIVVNNEGIPIRTTMDNSTTTQYSSLLHQLAAMARGVVRDVDPQNDLTFLRIRSKKHEIMVAPDKEHVLIVIQNPNE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MGQRSKVWQRRVSDGPICRICHEGGNGERLLSPCDCTGTLGTVHKTCLEKWLSSSNTSYCELCHTEFAVERRPRPVTEWLKDPGPRHEKRTLFCDMVCFLFITPLAAISGWLCLRGAQDHLQFNSRLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRRTNQKVLLLIPDSKTATTIHHSFLSSKLLKFASDETTV
The following text describes a protein:
Function:
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Subcellular Localization:
Nucleus.
Domain:
The N-terminus may interact with a transcriptional coactivator; The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.
Sequence:
MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV
The following text describes a protein:
Function:
Calcium channel mediating constitutive calcium ion entry.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVVTDSPLAPHKYVRRISKDFSTVRRYSNTPAVVVGSFRASTSAFIAAESAAHLPTCSSPTTRTPVSTPRGIRRRQRMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNILLKLHSEYTSITDELESVCHMIASPTVSLPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDYMILEGLIESRGSIDASAQGFEIGVSIDYSHRYPLRRETAVELSPSKPSVDGDLMGGGEGGGAGGGDSSDTSGAGSCGAMVGISSGFQLKNERPWQRNSSMEQQTYPSPLVPTRATSDFLNPPYEGRLFKKSSESLQKNSSTETDYSAHPYRFIKQSSNETNTSLTGSYNVDTPSLTAEPSLDAGDSHSATGISISVGAVGGTATARYQPIRTASVGAADGRRLREESSSSLDLSSSGPVTMQAAPAPPVRPMLLKKQFSVDQGKPSQTAAEAVPQTPEAAQAGQAKLISTLKPQPFASKLGMNVLKESSSSTDESVGSSAKSSNPALSIPQISTHLVQDEIAKLSSNIKSSTESEKDPPFNETMC
The following text describes a protein:
Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular Localization:
[Isoform 1]: Secreted; [Isoform 2]: Cell membrane; Single-pass membrane protein.
Sequence:
ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA
The following text describes a protein:
Function:
Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).
Sequence:
MAPKKKTVRKNKADVNEMTIIVEDSPLNKLNALNGLLEGGNGLSCISSELTDASYGPNLLEGLSKMRQEGFLCDLVISTKTKSFDVHKSVMASCSEYFYNILKKDPSTQRVDLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIQEMSVENCMYIANIAETYSLRNAKAAAQKFIRDNFLEFAETDHFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHKLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDVLYRDPEIGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLANMTQRRTHFSLSVFNGLLYAVGGRNAEGSLASLECYVPSANQWLPKAPLEVARCCHASAVAEGRVLVTGGYIGGAYSRSVCAYDPARDAWQERPALGTPRGWHCAVALGERVFVMGGSQLGPRGERVDVLTVESFCPASGQWSYAAPLPVGVSTAGASVLHGRAYLLGGWNEGERKYKKCIQCFNPELNEWTEDDELPEATVGVSCCALAMPNPVTRESRASSVSSVPVSI