lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MPPKKRAAAAASSKKPQPSQPSQPAKFGILHFFERQTQASQNAKRQKPDPPAPPPPPPPPPEKEPSEVSPEVTKTLAPKRVRFSPGMLIKQSQDDGVAEVVTWKISPVNHRLGTTKSKQFLGMAPHPYSSEKNSSLDAMKKWHSSPLGLSRCTTLGSNSGVLGSAIVGCDGVGDTQSPFRTPPSLSYGCNEQVSSGVTSEGGAEPSGAGQHKKALLDLLDQVEDAIMEEELPADPGNKGGQTTNEDITNNSRSPVADTDLTIPSKKTIHVPPFNSFLVLEVSEKHKADDSSCDRYPVKVLRLLNEHSGTECAVHLCDEWFDSIVGPGDTVNVIGEFSNHGKCIVDHDNNLVIVHPEQLISGTRAASSFQCLRRSVLDERLKSNEYSTSALTGTLLHQVFQAGLLNDAPSWQFLEQQAKEVLLKNIETLYACGVNESNMYSTLIEAIPKMLNWFKCFLKGSKCSDVDFGHNEVRKTVGVTEVMDIEEMAWAPRYGMKGVIDASVRSRVESHNGGSYDRIMPLEFKTGKATSGQAAMEHSAQVMLYTLLMTERYLNEDIDLGLLYYLHTDQTLGIKVKRTDLIGLIMRRNELATEILKASMSQSFPPMLQSPSTCNRCRHLISCTIYHKAHGGSGTTSGLGDLFDNLVNHLTVTHHNFLKHWDRLIDLEARASQVKKNILQPHNSNYGSGSSAVPYFVLDIKNGHSIDSSGKSKRYIYNFVQQKMQPETADQLDAQFDSIDFSLKVGDFVVLSTQSGRIAVANGCIREIISHSHITVSLPRRLRIPDSNSLSEQEDLTREIWRIDKDEFSSSFGIMRLNIVQLFAQNPQNSHLRKLIVDLEAPRFDSGGLFSQDPALSYIRSLPNLNNDQQRSLHKILGAKDYALILGMPGTGKTYTMVHAVKSLLIRGESILLTSYTNSAIDTLLMKLKTEGVDFIRIGRPEAVHPDVRAHCLSTTEAQSVDAIKARMEQVQVVGVTCLGMYHPLLAHKKFDTCIMDEAGQITLPVSLGPLMLATKFVLVGDHYQLPPLVQSSEARENGMGISLFWRLSEAHSQAISALRCQYRMSSGIMELSNSLIYGNRLCCGSLEIANAKLKFSGREPMQLKLKEILNPDRAVIFANTDQIPALEAKEHRTVNNPTEAHIISWIIKELLRRGVAQDAIGIITPYNAQVNIIQQYTDCLVEVHTIDKYQGRDKECIIVSFVRSTANSRASGSSLLGDWHRINVLLTRAKKKLIMVGSRGTLSTIPLLRLLVDKVAEIGGLLDLTNKDAHSFSRT
The following text describes a protein:
Function:
Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.
Subcellular Localization:
Cell membrane. Cytoplasm. Endoplasmic reticulum. Nucleus membrane.
Sequence:
MVAHTYNPNFALFYRFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPVGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
The following text describes a protein:
Function:
Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.
Subcellular Localization:
Nucleus.
Sequence:
MSTWVALNIEPDEAIEEEVDDTKEIQIEEALKLYQNALKLHSQGPRYYKQAGEAYEALLDSEIFKYPESLSDHKRAALQDAEPQVGGTTNDAVVGEAALDFNINDTTSSTLQQTIYLSYKNHGQYVLDALRASLQELSKLSEDSSHLSSKIAESSTTALAQFAEALERDDTDLNLWRQSARLCSALQSYRLTRFCLESVLADDDNRLEVRSEQLGLEETFAEEGLRKTLHSVQDRLSVSLVPIKKPKKALLKFFKQQSDPYPYLPSLPDNLQDLDSSRNPLAFRASTHEIKIDSLTWAAIGQAILTFLDDKNGTPSLAPGTSITISLPADSPELKTASITAQRRPSKAQVDENNNQDVQMDDAQSVGARSVTGAQGRELAMEHGDDQSSVDQRAEKQLIESLEVQSIQHQQSTDPQEDIKAEEDDLKYPENTSRKRSSGSAITEDQAERLRVKSRRTRLRDSLAEASTHTDDVVFDQAKYYEDLLEPYIQTDEGVFGTVGALLSKLGVEDLGTFEELRRSVASAGERKDSPVTPVNIDNAEVLLQDLRNVLTQWDERLYQVMQQSDSLAGLQDIKSMGRSGLAVFLEHSKKTTHKLKLKQTFSGEDELFDFIRAVNGSRLHLHDVVFEWLGCLLRPDYKNFLTHDNQFNDWSLVESSYVAYQWPTTLKDVVLQLLSLEDEYIHGKLEEGMQTLEHHILEAQSGTPFRYTAKHFADLEMIQAIYELHLDLYAPMNAPNNETDHRTRTLQQDRLARWSMLARSALTHFIDCCPERVNRERITIRHIWASTFHSNMGVDAQREHILLCLEDLKRLFSCLNEPVLSLANSSIMSELSCEAIDQEISKLNSMDFFTRIFNPDSEDPVGLIETIEPIVEPSAVQFEEGSEDRQSLQRREMGSFLDRGDATLRLFLWRRLQDAYRKIDYPPKVVSCHLRSIETIIKELRSQAYVEEPGEHRQATLVRWLKSLDGMLSKTVTTVLQESDKAYDCFDTEHVKSSMSAVAFLIRLLHSFVLYDDSVRVGQSPGIDLRAALAKSLENFKEKMRDMLVRCWVLLYTLLKEAIAQNQEMFDEPLEDRVYYLRAVHNSLGLRQMCKRSRNQFLKLVKSELLALDVEQDIEADICQILFDIHGVKLSLSDHLLSDHGCVPEKLDRSTAIMMIDFVMKQAKKINIKDLSKSELKNTIEKMQQSIGTTKAVPPVSYNRRILNAYLKTPINPSELVRAIQGVTDLPFIPVPSQTAVIANSGWYFLLGYAALTKFRSQKRLNPVPTTDLDEAISWFRQDLEHNTSRWESWYRLAQVWDSKVEEDITWSADKINNNRTELVTWQRNAIHCYAMAVATAAKTAESGPETGALLADLYTDFGIRLYSSSREPLSMAAFSVADFTRHFSNEESQQMYEGRPFKEMKVYNVWRLAAFLLRQALVDKPKNWMTHYMLSKCLWKMFSCDDSVRGSSKRISLDSVLDSLLDTIDALPQRKDSRSEPIFEPHYKLVSIIHKLVIKEVLTPAEASKTLVATPWARKVPACEDRNSWKKYILDVLKNLKNADKANWHHRMAVRSARIIYDDNKGAIAAAEAKSELTQQIFTKTMTIQVWKPEYERPGRHFVYTTRYAYFFVTLLDQLDDRANLEQLLRRVRKKQGDFINHTKLWEDMCLTYARVIRRAAGISEGHEESVFKPIGWEEFSSNTARLEELPQLAPESPSLLELLRDAIELKKLNNNLMKVALLEDLIADVYSRIYEVNLPILLEQVDEENKEKMKVDHILMTADGAATADTSTPPTSAPASEAPAPRGRTKGIARRDIQKRAEAIVSRKVPPRAPATKAPTTTETESATNATNSVGPKPVVEISVRQPPAAVVDSAGQQSDIPNSLHDSADDESELSEIDEDKLSKLAADPKMLFPNFGHRSRGSLEPDSELSAQASPSGDADVANENEEVGELEGDDREGEDEGEAGPDADLEEESMNDGDGDGDGDEAGEGEGENENENGNDGNVSGNDEDDDVDMEAGEEEEEAPGQDGEIEGNTTMEGTDAADGEDPEHVHRQEQEQEQQVGGEQEGETVYDTELATEL
The following text describes a protein:
Function:
Constitutive trypsin that is expressed 2 days after emergence, coinciding with host seeking behavior of the female.
Subcellular Localization:
Secreted.
Sequence:
MISNKIAILLAVLVVAVACAQARVALKHRSVQALPRFLPRPKYDVGHRIVGGFEIDVSETPYQVSLQYFNSHRCGGSVLNSKWILTAAHCTVNLQPSSLAVRLGSSRHASGGTVVRVARVLEHPNYDDSTIDYDFSLMELESELTFSDVVQPVSLPDQDEAVEDGTMTIVSGWGNTQSAAESNAILRAANVPTVNQKECTIAYSSSGGITDRMLCAGYKRGGKDACQGDSGGPLVVDGKLVGVVSWGFGCAMPGYPGVYARVAVVRDWVRENSGA
The following text describes a protein:
Function:
May be involved in transcriptional regulation. Is required for the differentiation of KISS1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus. Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MHGAARAPATSVSADCCIPAGLRLGPVPGTFKLGKYLSDRREPGPKKKVRMVRGELVDESGGSPLEWIGLIRAARNSQEQTLEAIADLPGGQIFYRALRDVQPGEELTVWYSNSLAQWFDIPTTATPTHDEKGEERYICWYCWRTFRYPNSLKAHLRFHCVFSGGGGGAFLHHEHAARQGAVPAADGLGLSPKPPAPDFAAPSQAGTLRPHPLGPPPVQACGAREGIKREASSAPSATSPTPGKWGQPKKGKEQLDRALDMSGAARGQGHFLGIVGGSSAGVGSLAFYPGVRSAFKPAGLARAAAAAHGDPYREESSSKQGAGLALGRLLGGGRACGRPGSGENSAAGGAGHHHHHHAHHHHHPKCLLAGDPPPPPPPGLPCSGALRGFPLLSVPPEEASAFKHVERAPPAAAALPGARYAQLPPAPGLPLERCALPPLDPGGLKAYPGGECSHLPAVMPAFTVYNGELLYGSPATTAYYPLKLHFGGLLKYPESISYFSGPAAAALSPAELGSLASIDREIAMHNQQLSEMAAGKGRGRLDSGTLPPAVAAAGGTGGGGSGGSGAGKPKTGHLCLYCGKLYSRKYGLKIHMRTHTGYKPLKCKVCLRPFGDPSNLNKHIRLHAEGNTPYRCEFCGKVLVRRRDLERHVKSRHPGQSLLAKAGDGPGAEPGYPPEPGDPKSDDSDVDVCFTDDQSDPEVGGGGERDL
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
METAEIPESDCPDKDLPAVFQCQRCNVIISDSIAFTAAHDDLKSITVNRVNSSVELSTKLITSTDGIDQGSTFSPLVCQGCKTVLGKVYRTTPRPLDDLRDYFTFDVNKLSVYQVGSSDSSALPESESPFQQYTNLKTLKETTLKLQVLMCAMHQRILNIEQSLEIEDTNVPENPLQSMTGLLGPGNPSGSSSTTNHQPKEGGAAKGQSLALQQKGENYSAVLPGIRNGPEMGPHPMKDVQRSDAFERASGTLQTSSNSETSGATASNSKGTKRSRGSSSKASRGRSSRGKASGSHPTSSDSDSETSGATMSNSKRGRGSSTKTPRGRSRGGKGQENASNLNQVRGTKRTNDFGEIPGDQDELEHGLELLSPIRKKSSVRRNKPL
The following text describes a protein:
Function:
The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MLITPAYAQAAGAGDTNSMLMSLLPFALIFVIMYFLILRPQQKKVRDHADLVKNIRRGDTVVTSGGLVGKVTKVVDDDQIEFEISDGVRVRQMRQMISGVRAKGEPAKESKDSAKEAAKDDAASK
The following text describes a protein:
Function:
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
Subcellular Localization:
Periplasm.
Sequence:
MRNLTFLTRCKPLAASVLALMLLGGAAKSFANNDLPDLGTAAVNTFSLEKEMIYGDAYMRVIRSSAPMLNDPVLSQYLTELGNKLVAHATGVKTPFYFFLLQNDEINAFAFFGGHVAVHTGLFLNADNESELASVLGHEITHVTQRHLARSLEAQQKTGPATVAGLLGAILLTIAVPQAGMAALATTQAMATQSKINYTRLHEKEADRIGMQILVDAGFDPNASAEFFGKLASRYRFTTTPPQMLLTHPLPESRISEARDRAQQYPHRYVPDNLNFQLAKARIQVRFSSFSDDAVLSMFEKQLNKQTYGFKEAALYGKALALFRLKKFDESEKIVDELLKIDDNNLFYIDTKTDLLNERKDYAQAIKLLEAQRNLKPTSQVINANLANIYIEAGEPAKAIPLLEDMIFLDKQNQLPYQLLNLAYKKLGNPGMEYFSNAELMALGANYKGAIDQLNFAYRASEGNQLQLARIEARIRQFKQADREMDALK
The following text describes a protein:
Function:
Negative regulator of mitosis in E.nidulans. This protein is part of a regulatory pathway that includes the nimA protein kinase. It is required to prevent premature entry into mitosis. Mutations to this protein both cause cells to enter mitosis and prevent them from leaving mitosis.
Sequence:
MSTVRSLGLHDSSAISFLIAEDLLPAEPSEELYSWTTSINNGPNGPVEDELVWTKSCVVWTRAGVIKRVFRLDFEKEDIKYALLTNFAVNNVKRTSDLSSLAIPQTTSQQSNRPSGSESLDGKESRRSSTSKHSSRAVVVVLKTQAHIFFLEGNSHVVPLPFEVDSVFATPRGLLFQRKVADESNTSSYPMVPPNSFMSFSQDFCASQFLDYTSGKVQRPSLSTIPAQSPSWKSRPNKRADLPRVFSLMDPHSEMGLVVTNQASRWLHTSLSGRPSGFDVLDPADEIVYVSPRDELAGTFRADPKSPLILVLTVNTITGLYTLWTARYRDNESIPSHRKKKRRDTGGTRSKRRSSHFGMATGTTTPGARPSAGRESFGPRGDNWNASVMSHSQYSTEGRPDDDEDDFASKLGQDFGEIGVPSKTSRRVSSMLARADLATSQDRITFSDLVTGSQSSTIHPGGLRQSIGAGSTRGSFGFNPRSSLPPGAGSIYSTTSSFVDPPVDKLLEELNNESLFEGIENMDLKESAAGLPEEVFLSKVESFSSKFSGSFLAPSKIKSSKRLKVVTLCPTDYASSHVGESTSMALYLVDQEAKSLTVVNIRVESVKKPAKDVVFLKRSKNKATSDERALLVQASGIQHVSGTLDVCKVVDGGLSRIITLSVNDAGATVLHLQMPWNDPIIIELPSKFMLHEMDALSSIMTVNTSREGSVNRVMADFSMTMTGLDHPAVDGKFDVVDSAKRRHKLQLCMEPTNPLVRRAFGVCRFALCGYFPDKVADGLLMGWWKTLKWLQEREVCENDLEWTALVVTLFAQAIPFIEGDQSGGTTRLTRRKRGLLRSSSGSYVDTESWESMLEQESGSAGVVASWMNTASWGWVVEQDAEDESTASYGRKPNKEPLSSSRSTCRKNTYLLRCATLTREFLRTPQGIAAVGCDGHLRKALSNSEHSIHTPLCTILVALHLLREEQKLSACDEEQSHKTLGLLAPVLAQLGGWLGWPSWNWAEDSYYGSEIASINRWQFENTRMAGPDLPAEPLPPPSIFAYLEKAWRGESCQFWTLLNLVNFDGHPRRGRLWQWCSTLTPRTLALEGFVSEMRHKLSVLERIQLLHRWGLTRSVIETFPAGISTPLYEAIIESQTHASTSWSSSFLGLIDRDDLNISSQSSTTRPPPPLSLNVSHDAIRDYHQISNSTLDIDAINSFEASAEADRFSVTRLIFREDKRFIEAARLLNQSKAPAAECHPEPEWTDSDLLEAQKEVVQLVTLRTLSIPTGRAMLAFSGRLPLLTEKLPIPSFSLQCVMKPSNVTISADRASFHEEKICWAFFHNGVSTGLAISKNSKGIDTSWILFNKPQELTNRHAGFLLALGLNGHLRSLAKWVAFKYLTPKHTMTSIGLLLGLSASYLGTMDTLVTRLLSVHVTRMLPMGAAELNLSPLTQTAGIMGIGLLYCNSQHRRMSEVMLSEIENADQEEGSATNDYLRNEGYRLAAGFALGFINLGKGKDLKGMRDMHIVERLLAVAVGTKNVDLAHVLDRATAGATIALAIIFMKTNDETLAQKVDIPDTTVRFDYVRPDLFLLRTLARHIIMWDRIQACDEWFIGSLPEVYRRRYRLTGVRRLKSNDMPFFNIIAGLCFALGLRFAGSPDPTVRDILLSYLDQFIRISRLPAPNYDARLARNSVRHCQDVVALSLAAVMAGTGDLALFRRLRSLHGRVDPDTPYGSHMAAHMAIGMLFLGGGSYTLGTSNLAVASLICSLYPIFPTTVLDNECHLQAFRHLWVLAAEPRCIVPRDLDSRRPISMPITVTDSDGVSGTLTAPCLLPDLNRIAKVEVLSPDYWPLVLDFDSNPGVREKFQQGDQSIYLRRKATYNPTGSSFFSSTLAGLSSAQDILPSASTSASNQGKGLSPSALPNVSALLSKESHRFTPKPAAQSIWDWIFQLDSLHGILDAREKELVLPSSFPARPRPSSTPHDAPWLRQSAVDSKLLAESIAQNVIQSATGRGGNPDEVRDRLWQLRLLFAWIDAGSSFPSESDEEKRDRQETGSMPSSGHWLRRDYVEDLRWKIWGVQARGSEGS
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Subcellular Localization:
Nucleus.
Sequence:
MGDKGRSALRPLHNTGEAMGERRQLTKKMYAWQRDPRVGRRTGIVMKKDVKKDAYGFDDVNDYFSDTESEESIAISEPSTKKHPKPKKDIRPRRMSSFSPIKPDTGDLSRTSTSPAVSPAKDSAPVDNPDPAVSSAPEEIPPPAVSSSVISPIPSPTPIENSTSADSPAPAHSAVSPAQSDSAGAMPEASPVSNHEVLSQSADVSSMNFTADDSGSISKISSQNPNTVVKPVAALKKRLTFGGAASDSPDITAQKESVSTIETASSDREAVGEVIEAVVCEKPAKQTKRRSQRKGKAKAVPKPAETTEEEITPEEEGTGEEERTEEKGAAEKEDDVLAFPAKEAKRRSQRREKPKPPETTEEERTAEKEGATEKEGAAEKEGAAENEARQQREVLAEDSERDGSGRTVQQEEQKGISADGANKKQKDQKETVPKKVVQKVRGVRKQPLVVQMVDSDDDDDDDDALLCLKGFRVNLTNRQNTSAESQATKEPTAGGKRSKNTSQQPSKKAKGDNPNDETVKNKKAERSRKRKKNKAMDSETQPKMINDTTQSISSPEKRRKRSEPQESRMDTMVDDAHREGPSAPVQEEAGDEDSNSFNSGPQDFVLPSDREEAEDVEIPFQPSPRMSNKKRSQKRRGRKNLSSQFLDESSEIQNSTTENLEESTGPKRRKTAKAKERRTVPKRPGKQRRQVSPVENSNNDSLTVEEDLQTSDLSSQPGQESSASDGEVRKKNRGRPRDLSSLPAQESSASDGEVRKKKRGRPRKEIQSARATNESSEIQSEANVSARLEDNTEPKKKRGKKSAKRPGKQRRTDSYDHSLSNGDDVPVSATPSRSILKGGKNYTPRSSTSTLPRASVTSPKHYADVTVSKSAAKKAPAAEARQLRIISPKKDHTPGVRRSRRNRIRPLAWWEHERVVYERRNSGRVMVDVQKPEIKDTGRRPKKTQIAKVHGRPRKGASKPQQPLQQETVPNVSAHMDVPGDWEEVENPMIPVVNPATREEILVDCVKTSSMFDFRGPQGKAAVEEDGIKVCKALRQPQFGLGQIILEPKQEKGTQFVRNDTLAYVVMTGKLAVTIHRSTVMMQSGDMFLIPAGNTYNIKNLRKDRARLCFCQIKPSAQ
The following text describes a protein:
Function:
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine (By similarity). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (By similarity). Also has adenosine deaminase activity (By similarity). Also acts as a multicopper oxidase able to oxidize a wide variety of polyphenols and related compounds in vitro. Displays substrate preference as follows: syringaldazine > 2,6-dimethoxyphenol > veratryl alcohol > guaiacol > tetramethylbenzidine > 4-methoxybenzyl alcohol > 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) >> phenol red > 1-hydroxybenzotriazole. Cannot use 3,4-dimetoxybenzyl alcohol and violuric acid as substrates. As this enzyme is derived from a rumen microbial community, it may have a role in the digestion of complex plant materials such as ryegrass lignin.
Sequence:
MIELEKLDFAKSVEGVEAFSTTRGQVDGRNAYSGVNLCDYVGDDALRVLDARLTLAMQLGVDLDDLVMPRQTHSCRVAVIDERFRALDIDEQEAALEGVDALVTRLQGIVIGVNTADCVPIVLVDSQAGIVAVSHAGWRGTVGRIAKAVVEEMCRQGATVDRIQAAMGPSICQDCFEVGDEVVEAFKKAHFNLNDIVVRNPATGKAHIDLRAANRAVLVAAGVPAANIVESQHCSRCEHTSFFSARRLGINSGRTFTGIYRK
The following text describes a protein:
Function:
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins (Siwi or Ago3) and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs: acts by recruiting the exonuclease PNLDC1/trimmer to Siwi-bound pre-piRNAs.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Note=Localizes to the outer surface of mitochondria.
Domain:
The Tudor domain specifically recognizes and binds symmetrically methylated Siwi and Ago3.
Sequence:
MSLNTKLALPIALGLSLVTVTAFVAYYVLKRDEEENDNKTVKITKINTIEIHVPKSIVPALIGRNGSNIKDLQKKSGAQIHFKKFTDQDYDVCVVRGRADTTQLAETLIHDFIKQQPTIMSESITVPSWSCGRIIGSGGENVNDISHRSGARVKVESPKSTDKVAEHLVTFRGTKEQIEVAKKLVENCVSLERCRREIEQSKRPPRHSSSPPSPCPSPGDRDADADAQGDVDHTRVKYKRPETTGPSIEVYVSAVSSPSRFWVQFVGPQVAQLDDLVAHMTEYYSKKENREAHTLRHVSVGQVVAAVFRHDGRWYRARVHDIRPNEFDSSQQVADVFYLDYGDSEYVATHELCELRADLLRLRFQAMECFLAGVRPASGEEAVSPSGQTWDKWHPQAVERFEELTQVARWKALVSRTCTYKKTATAEGEKDKEIPGIKLFDVTDEGELDVGAVLVAEGWAVAGPAPSPRPSPPRGHTTPFGDLSKSKVLSMTGGGGRSSSVPKDHKDDGSNVLTVEGDDSKDKDGITASKSLASGLEKSDRHPLSISNFDLSYPDPSRNKQLNGSDDFLHGERQNIDNEITIDTLVPPSPLSNAPILSKTLQDEFKANMNRIDSHHSNLENLGKSAFEK
The following text describes a protein:
Function:
Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions. Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption. Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption. Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate. Urate and orotate transports are Cl(-)-dependent. Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSSPGVAFVSSTYF
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC); Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MDRSGFGEMLSPVIREAEVTRTARKQSAQKRVLIRASQDEIFTNTTPRNQVIPRTPSSFRPPFTPPNRSLLRQPDASSIFGTGGRSPRLTQSSGFLGNLSMVTNLDDSNWAAAFSSQRAGLFTNTEPHSVTEDVTLSAVMLREDDPGEAASMSMFSDFLQSFLKHSSTTVFELVEEYENICSSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVTWRLLASLYRDRIQSALEDENIFAVTAFNASEKAVVEALFQRDSLVRQCQLVVDWLESIAKDEIGDFSDNIEFYAKSVYWENTLHTLKQRQLPSYIGSVRPLVTELDPDAPIRQKMPLDDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRCIWKISCWRMAEDEHFNRYERAIYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIRTSVMTLDETEELPREYLETNWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLINEKHTDLIAFYTCHLPQDLAVAQYALFLEGVTEFEQRHHCLELAKEADLDIATITKTVVENTRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFLASKKHEAAKEVFVKIPQDSIAEIYNQWEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSAPQKPTLIPQATFTEKVAHEHKEKKYEMDYGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAEEDHERTHQMVLLRQLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLDQGLDPLGYEIQS
The following text describes a protein:
Function:
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.
Subcellular Localization:
Mitochondrion.
Sequence:
MRLSAAINSFKSSNLISWKTTGKLQQTLAGCIELSGKTLHSGKVSKVKIWPGFAGEGRYFEFHSNLIPASIDFVRESLLCTTLCKDGYKIRTVEHLLSALEAKGIDNCRIQIQSLDSEDTEVEVPFFDGSANAWVEAIEQVGRKEALDRCGNNVEKLAPHLSEPFYVSRNDSFMAAFPASKVHISCGIDFPKVPAIGCQWFSSAALDDSYEKHIACSRTFCIYEEVEHMCSMGLIKGGSLDNAIVCSATKGWLNPPLRFPDEPCRHKVLDLIGDLSLFARSGSQGFPMARVISFKVSALSLSLGVSVRLNRVKLNKKILVN
The following text describes a protein:
Function:
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MTTSVLARRLLQFCCLVCLSAIPVFSQEEPLQLELTSQGVLCGPEYDGFCLNGGECEIIPDFARPRCSCTWEYMGERCQRGNILAIQAMQEELRDYYIIMSAMGGVLVALMALGVGYIIYRKCGKPDPRPESV
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence:
MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLPNLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRSTIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHIEADRYGNIVDFRILKE
The following text describes a protein:
Function:
Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRGRSLMSRPKEMTRAVIVGHKSILKQTIDSLYDTNLFHIEDFVEDESGFKISKPLKNAEEVSKKLVKIRSIANYLGIVHKEPVVQKTDSVLRDLDSKLDELDRAIATKTDAIAQLENELKDLDSQKRELMPYLAINLDFDDYRGYESLKVFAGMVKGNLDGSQISSITKAYELYFDPQSKAIVLFVAKSDADKVYELLQGIGFRELRVPERGGVPSELLRFIEQKEAEVTRKIESLRNEIESLKTKYADFILASDEILSIESQKAELPLRIATSANAFIIEGWTPTENYDKVVSAVNSATNGKAYVSSLEIEEEEEEHVPVEYNNSKVAAPMQQIMDLYSRPKYTELDPSSVILITFPLMYGLILGDIGYALILGAIALAVKKAIKSDAVGDLMNILIYCQISTFIFGIIYGEFLGFSLASLHTEHGSVPGLIPGWETIVLFEGLGGEEFTFPIHRTHMVMTMIAVTVLIGLLQLNLGFLLGFANISKHHGVKHAVLEKGSWLVIELGVLLAAIGYLGGTGLAYVGAVVLVLGIVMLTMGEGIKGPIELPSLMGNALSYARIIAVGLSSIYIASTVNDIAFEMIWADHSKIGFVAIAAILVFILGHALNTVLSIIAPGLHALRLQYVEFFGKFYEGGGRKYNPFGYIRKYTEE
The following text describes a protein:
Function:
Catalyzes the formation of anthraniloyl-CoA, which is the priming step for entry into the Pseudomonas quinolone signal (PQS) biosynthetic pathway. Also active on a variety of aromatic substrates, including benzoate and chloro and fluoro derivatives of anthranilate.
Sequence:
MSTLANLTEVLFRLDFDPDTAVYHYRGQTLSRLQCRTYILSQASQLARLLKPGDRVVLALNDSPSLACLFLACIAVGAIPAVINPKSREQALADIAADCQASLVVREADAPSLSGPLAPLTLRAAAGRPLLDDFSLDALVGPADLDWSAFHRQDPAAACFLQYTSGSTGAPKGVMHSLRNTLGFCRAFATELLALQAGDRLYSIPKMFFGYGMGNSLFFPWFSGASALLDDTWPSPERVLENLVAFRPRVLFGVPAIYASLRPQARELLSSVRLAFSAGSPLPRGEFEFWAAHGLEICDGIGATEVGHVFLANRPGQARADSTGLPLPGYECRLVDREGHTIEEAGRQGVLLVRGPGLSPGYWRASEEQQARFAGGWYRTGDLFERDESGAYRHCGREDDLFKVNGRWVVPTQVEQAICRHLPEVSEAVLVPTCRLHDGLRPTLFVTLATPLDDNQILLAQRIDQHLAEQIPSHMLPSQLHVLPALPRNDNGKLARAELRHLADTLYHDNLPEERAC
The following text describes a protein:
Function:
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
Sequence:
MKREDLTEKLLDIKREKGWSWKYICEQIGGYAEVLIVGAILGQMKLTKPQAANAGELFGLSKAETAMLNEVPMRGTGTPMPPTDPLIYRFYEMVMVNGPAWKALIEEEFGDGIMSAIDFDMGIERVANPKGDRVKITMSGKFLPYKYYGASGNVPEYGFKEG
The following text describes a protein:
Function:
In vivo, this neurotoxin paralyzes about 70% of blowflies (L.caesar) one hour after intrathoracic injection, when tested at high doses (45 nmol/g).
Subcellular Localization:
Secreted.
Sequence:
MKLIYIFSLVAVIAVTMIPGIMGEAEAEGRPPQIGIFDQIDKGMAAFMDLFKG
The following text describes a protein:
Function:
May act as RNA methyltransferase.
Sequence:
MSEQPRRPRKTGKPYRRPQKDPVRMLAFEALRAVDERDAYANLVLPPLLRKAREKEGPEKFDARDAALATELVYGTLRRQGTYDAIIADCVDRPLREVDPPVLDVLSLGVHQLLGTRIPSHAAVSASVELARVVLGDGRAKFVNAVLRKVARDDLDGWLERVAPPYDEDPEDHLAVVHSHPRWVVSALWDSLGGGRAGIEELLAADNERPEVTLVARPGRATREELLGEEAAVPGRWSPYAVRLSEGGEPGAVDAVRENRAGVQDEGSQLVALALANAPLDGPDRRWLDGCAGPGGKAALLGALAAERGAFLLASEKQPHRAGLVARALDGNPGPYQVIAADGTRPAWRPGSFDRVLVDVPCTGLGALRRRPEARWRRRPEDLDGFAPLQRGLLRNALEAVRVGGVVAYATCSPHLAETRAVVTDVLKQHPGTELLDARPLLPGVPGLGEGPDVQLWPHVHGTDAMYLALLRRTS
The following text describes a protein:
Function:
May play a role in magnetite crystal maturation (Probable). May transfer electrons to balance the Fe(2+)-Fe(3+) ratio during magnetite formation (Probable).
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Magnetosome membrane; Single-pass membrane protein.
Sequence:
MGTPGGGRRWMTLISITLLMVVGLGLYWDELSLSAGISPATSPRRAEGLLLGRLPLPMEPSILSPLEHLIEPPLQYKLMTIRHIPPVMPGTGMPHPYVGDCIQCHLMVGGPAAGSQFKTPYGAVLENLSRVRKLGPPILPTTRQPHPPAGRCIKCHDIVVKVPVEKKSGIKWLL