lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.
Subcellular Localization:
Nucleus.
Sequence:
MEVDPMENAADSASPSNPQLTTLQPAAHRDRFLHLQTSARYAGAVDPSARFKTILALVDAYRNAAEFTSLLQHDWDIFLALETRLAAETSPLSPDTLQTLFELHKNAVSHLPTNCLIKRYISILLTYFSQLYHVDNALVVLQSSKDTSTTSDPALKWTSLDSCPTINLPHSTYIPSSLPPLARDVAETAVWEAVCGVEAIRWRIREAYTRCAYQLQESQDVWKLYLGFEEMLLASTHVARDQQLETVRQVYLARLRVPHTAIDDTFQAYSSFVTQHLPPQQYESEMSAANVLVAESKAILRQREQHEDALAMLFRPGQLHGTGSRQDLDGFAACCKAYVRWQSARAVRALRSKDKSAAQTELNLTCALFDRLVAHFGLHPPTTHKHELVYYSDDVSSSEGYPREFKRLGQAEREARIQQEQQLFSERHSLATELWLDYIAVLTCSPRPDASLIMDVCTRAVQCLPTAVSLHCVLMRSSARFQRSRAQIEQLFEKVATPGALELKGPELTDLCLARIDCERELATFDLVVKAGAEIDVDPAQDMDKFTEIYALLSYSLGKLAELHDDQRDPSLRLEKAIVNWVERAVFAMGGPASEGGAGLNELAESVWQTAVVQQPDNALVYREAAGYWLRRFEARKARGWFKAGISKLERKQSQDARPEYQALLQDWVQFEHLHGSIEEVEYAEGKSRAERQRALEAWYAQYAQYGYSTEPQTQAQSYSHMNRDLNSTMQVESPSNHLDRNQTGKRKADDDEKEADTSIADAPMSIRADALCAPIDTSSEQPKKTRAHDAESAPSRDREHCSVLVSNLDPTADASAVRHLLRGCGRIVELSGPNILTSPTGSTSAAALVEFADPNGASSALTRHNKTISSTPVSIHIGWKCTLFVTNFPEDWNDSSIRSTFAAHGLVFTVRWPSKRFASTRRFCYVQYTTPDSAAAAVAALDKTEVAPGRMLNVALSDPSRRKQRTDAQENAKELFVSGFARNITEEELRVYFESYGTVKGVRLLRNAEGALRGIGFVDFESQLEAQRAMRELNSTKWRGKTISVTIADTRSHGASCSAQREDVQERRAKSVRVTGLPVDAQEALIQQAVEREVGLGSVKQVLWRPDGVNQKATVEFSEFKDAGKAVLIGGAGGIRYGDVVLNVSAAEEEGAAGDGPKPQVAVGEVQPAAALSFMPRSSRGGRGRGRGRAFALAYASHAATSHVAAEGVSNAGEDMDVEPAGNDETSGKPSGQDRFRAMLQRQ
The following text describes a protein:
Function:
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent manner.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MKQEIKPATGRLGVLVVGVGGAVATTMIVGTLASRKGLAKPIGSITQLATMRMENNEEKLIKDVVPLTDLNDIVFGGWDIFPDNAYEAAMYAEVLKEKDLNGVKDELEAIKPMPAAFDHNWAKRLNGTHIKKAATRWEMVEQLRQDIRDFKAANNCERVVVLWAASTEIYIPLSDEHMSLAALEKAMKDNNTEVISPSMCYAYAAIAEDAPFVMGAPNLCVDTPAMWEFSKQKNVPISGKDFKSGQTLMKTVLAPMFKTRMLGVNGWFSTNILGNRDGEVLDDPDNFKTKEVSKLSVIDTIFEPEKYPDLYGDVYHKVRINYYPPRKDNKEAWDNIDIFGWMGYPMEIKVNFLCRDSILAAPIALDLVLFSDLAMRAGMCGIQTWLSFFCKSPMHDFEHQPEHDLFTQWRMVKQTLRNMIGEKEPDYLA
The following text describes a protein:
Function:
May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNTQAERSIIGMIDMFHKYTGRDGKIEKPSLLTMMKENFPNFLSACDKKGIHYLATVFEKKDKNEDKKIDFSEFLSLLGDIAADYHKQSHGAAPCSGGSQ
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MADQSCIAEALQWAYVQLAASSESAHLDAEVLLLYCLNKNRAYLYTWPEKALSVEQWKRFQQMVQRRQQGVPVAHIVGEREFWSLPFIVNDTTLIPRPDTEILVESALNLPLESNAKVLDLGTGTGAIALALASERAAWQITAVDKVEDAVALAKANRTNLKLEQVEILQSDWFSAVTSHDFDLIVSNPPYIDEADEHLHQGDVRFEPQSALTAADEGFADLYYIAKTARDYLKPNGYILLEHGFEQAVKLRAKLIELGYQNVATVRDFGSNDRCTMGKWMGLIGI
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MRWNLRFFSPYFLWYNSLMPLTEFTIIENYFHRPKKPAKNVVVGIGDDAAVIEIPKEQQVVISVDTLVEGVHFPINTPPRDLGHKALAVSLSDIASMGAIPHTVLLALTIQKTNEIWLKAFAEGFFSLADRYQVSLIGGDVTQGPLCISITATGLIPKNEMICRNGATVGDLIYLTGTVGDAGLALALLKQNKKIDPFLLTRLNCPTPRIEAGVALRGIASAAIDISDGVVADLEKMARASQVGAKIYVERLPLSDSLKRYCPLKKAWEYALTSGDDYELCFTIPKERSEPLEEVFHSLDCECRCIGEIIQGESVTVIDPHNRPINIAKKGYEHFSNA
The following text describes a protein:
Function:
Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle.
Subcellular Localization:
Secreted.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MPPFYIVITFLLSTVFRISQSVHHHLNEEELKQVFGVSNKHDVPEYSLIEATRHPLKNGNLKMKFTAWNDTYHLNLRKNSRIVSPHIISVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFLVLQTLPKRVHHLQKERHLVYKRSAGLLTNAESKIREEITRLQEEQESFCDTSEQLDDPAMTIPAHLHFNYTIPTSAQLDSSFIFPNMDPITLEIGLFLDSKLFEHFEREYIQDAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALSTGVHKNGQAQSLLDAFCRYQAHMNPGTDLTDMNHYDHGVLLTGYDIYHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMGHNMGMVHDGVQNQCNKGCCLMSAVNGAGKTTWSDCSVREFNAFLLQLDESGRGNCLRDASPGLISTNHLSDLRLPGQRFTADQQCSYFWGRDYKVEIPNGKAMDDICRILWCGNSGSTISTAHPALEGSWCGANKWCHKGQCTHWTFGLTPVPIDGEWSEWGGAEKGCPIQQCAVSGSITVQGQHRDCVNPAPNNGGKTCEGANIRGIVCGATSSNCLGFTREEFGNKICSSIKYDPHKPDQQLTGEGFEHSTQPCRVWCHLIGSELIRNKGQFPDGTPCGFDAYCVGGQCLALSCDNKALVEQPEDCPRIEGRSVHQWEEWSSWSECSVSCGLGGREVRERKCSSGRKCQGVSEESRPCEGVLRDCEEFGEWKEWGSCSEKCALGVQKRFRPCLTDQCSSKHLQEERPCDNEGCWTNWDEWSSCSQSCGGGRRYRIRKCLDDKCDGDDLEKESCNTQKCISQSWGDWLPCSVSCGIGFQIRERLCDGELCATANKQARTCNQQQCPSAFSLSVWSEWGEWTTCSATCGEGLQSRERSCRRGSCTEDDASQTRRCVNGPCEHSYLTWSEWTTCETCSSFDSRKRIAKCDGTTENCQDKIDEETCDIACLREKHSFGPISPRRPKLITSNDLRKAFGRPLLPIESIHSEKWSEWGPCSVTCGSGRRVRTRGCQEASCPEQHIQTEECNLNSCLELFIWSDWSSCSKSCGQDGIQTRQKLCLFNNAECSSYAESRRCKDLPSCSSISSGRTISENGFDAPRWSEWSSWSACSCFSLTSTRRRFCQVVDPTVQGFCAGAILEQIPCAPGSCSPSAGGWSLWSEWSSCSKDCGDTGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDNVCSDEKVDGGWTDWTAWSECTDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPARCHLRDGGWSTWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQSCSGLAHQTSLCDLPACDHESDGEWSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSPSTALCSSFITSSHLADGYFIDTDQQQ
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MAAGSASRATERLKEGDGLYEELWRACAGPLVEVPRVDERVFYFPQGHLEQLETWTDQELNQHIPLFNLPPKILCRVVNINLKAEPETDEAYAQITLIPESDVRNNQNEPTCPVPCVVEPPRPAVHSFCKILTASDTSTHGGFSVLRRHATECLPPLDMSQQTPAQELVAKDLHGQEWRFKHIFRGQPRRHLLTTGWSTFVASKKLAAGDALILMRGENDELRVGVRRLVHRQNTMPSSVISSHSMHVGVLATASHAISTHSLFTVYYKPRTSQFIVGVNKYLETIKNEFTVGMRFKMRFEGEDVPEKRFTGTITGIGDISSQWPCSKWRSLKVQWDEASSILRPEKISPWDVEPFGGSMSTSSDAQAGFIKNKRAWSPLDLLGHEPSSTIWNPAKAQISDLGSMSSIIAQSLEKRFLWFSGQTESIDNNSLHSPSSCNRRLSDHWLRDSKSPLESTSSSLINVSLKLSKGTVACDTKTTLTSWLPASNPVTEDPSLELECKMENQKKPKSGSGYRLFGIDLVCPSNDISSTMKLSVEVVSQSNATIEDPVPATPLVEDIDGQSGLSKASKEVKQVLQVSPKEIQRKQNSSTRSCIKVHMQGIGVGRAVDLANFEGYDELMLELEQMFEIKGELRCHKKWEVAFNDDDGVMILVGDYPWPVFCKLARKIFIYASEEVKKMEPKSKLPAVPSTDGEAA
The following text describes a protein:
Function:
Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
MAARLPTKALSLKQFMVRRQVLGLYRDLMKALNKIPDKNHQKELKEWTREEFKQNKTETDPAAIQFMITRGQQALREIASTISLAK
The following text describes a protein:
Function:
Catalyzes the degradation of bis(hydroxyethyl) terephthalate (BHET), a derived-oligomer of the plastic poly(ethylene terephthalate) (PET), hydrolyzing BHET to mono(2-hydroxyethyl) terephthalate (MHET). Shows no activity against PET.
Subcellular Localization:
Secreted.
Sequence:
MQQNPHTHAAPGAARPVLRGVRRRLAAVTAAVAAVLVLGTLTGPGAQAADNPYERGPAPTESSIEALRGPYSVADTSVSSLAVTGFGGGTIYYPTSTSDGTFGAVVIAPGFTAYQSSIAWLGPRLASQGFVVFTIDTNTTLDQPDSRGRQLLAALDYLTGRSSVRGRIDSGRLGVMGHSMGGGGTLEAAKSRPSLQAAIPLTPWNLDKSWPEVSTPTLVVGADGDTIAPVASHAEPFYSGLPSSTDRAYLELNNATHFSPNTSNTTIAKYSISWLKRFIDDDTRYEQFLCPLPRPSLTIEEYRGNCPHGS
The following text describes a protein:
Function:
Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. May function in assembly or stabilization of the NDH complex.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane.
Sequence:
MALVHYMNVSRSTFPLSRSSKINLSSSFASLPLQFHKNIKRLESSVPPSASASASPAFPIDVEYLRREFSGHGATFEDIGETCIARLKLDNGSSANVMLTRGMITSYKVRVWHGGKVELLHTWVEQEEEEVVIRGGVSSAFRSSDSDEISDWRLQGISGDSKDCVQMELRRSDKKIKEIELKQIISLRENTLSIELSMTNKGISPIKLEGCSLVSYLTVSTPEATYAVGLEGSDFVETTPFLPRFGVVQGEKEEEKPGFGGEEESNYKQLNREMSRIYTCAPKSFTVIDRGRRNSVVVGREGFEEVYMYSPGSRLESYTKSAYVCIGPSSLLSPISLESGCVWRGVLHLHNPNS
The following text describes a protein:
Function:
Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with per is required for nuclear localization.
Sequence:
MDWLLATPQLYSAFSSLGCLEGDTYVVNPNALAILEEINYKLTYEDQTLRTFRRAIGFGQNVRSDLIPLLENAKDDAVLESVIRILVNLTVPVECLFSVDVMYRTDVGRHTIFELNKLLYTSKEAFTEARSTKSVVEYMKHILESDPKLSPHKCDQINNCLLLLRNILHIPETHAHCVMPMMQSMPHGISMQNTILWNLFIQSIDKLLLYLMTCPQRAFWGVTMVQLIALIYKDQHVSTLQKLLSLWFEASLSESSEDNESNTSPPKQGSGDSSPMLTSDPTSDSSDNGSNGRGMGGGMREGTAATLQEVSRKGQEYQNAMARVPADKPDGSEEASDMTGNDSEQPGSPEQSQPAGESMDDGDYEDQRHRQLNEHGEEDEDEDEVEEEEYLQLGPASEPLNLTQQPADKVNNTTNPTSSAPQGCLGNEPFKPPPPLPVRASTSAHAQMQKFNESSYASHVSAVKLGQKSPHAGQLQLTKGKCCPQKRECPSSQSELSDCGYGTQVENQESISTSSNDDDGPQGKPQHQKPPCNTKPRNKPRTIMSPMDKKELRRKKLVKRSKSSLINMKGLVQHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKFAAQLELDMEHIDTILTYDVLSYLTYEGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVTHLNEDDKAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDSSAKLGGCQTIRLSEHITQFATLEVMHYYGILLEDFNNNGEFVNDCIFTMMHHIGGDLGQIGVLFQPIILKTYSRIWEADYELCDDWSDLIEYVIHKFMNTPPKSPLTIPTTSLTEMTKEHNQEHTVCSWSQEEMDTLYWYYVQSKKNNDIVGKIVKLFSNNGNKLKTRISIIQQLLQQDIITLLEYDDLMKFEDAEYQRTLLTTPTSATTESGIEIKECAYGKPSDDVQILLDLIIKENKAQHLLWLQRILIECCFVKLTLRSGLKVPEGDHIMEPVAYHCICKQKSIPVVQWNNEQSTTMLYQPFVLLLHKLGIQLPADAGSIFARIPDYWTPETMYGLAKKLGPLDKLNLKFDASELEDATASSPSRYHHTGPRNSLSSVSSLDVDLGDTEELALIPEVDAAVEKAHAMASTPSPSEIFAVPKTKHCNSIIRYTPDPTPPVPNWLQLVMRSKCNHRTGPSGDPSDCIGSSSTTVDDEGFGKSISAATSQAASTSMSTVNPTTTLSLNMLNTFMGSHNENSSSSGCGGTVSSLSMVALMSTGAAGGGGNTSGLEMDVDASMKSSFERLEVNGSHFSRANNLDQEYSAMVASVYEKEKELNSDNVSLASDLTRMYVSDEDDRLERTEIRVPHYH
The following text describes a protein:
Function:
Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTTDTPPPFDNSPNALLVSASYDLSIRLWQLASGKCIGTIPHNEGQVNALSLTSTGRDLAVGAWQRVRIYDVSSGKDPKATIELPRNVTVVGFEAAGRWMYTGGEDGVCRIWEMRNNQLVANRLLSFSGNGVTSIVPNTNQTDLFISTNSGHVWIWDVVNHMFMRLPMPDDLRMQEYVHRLAVHPSGKKLSGVTNQGRLLCWDLMTRQVEAHSFDMFKSPIVPIEQDTGTYGCLRDEDRQHRMQTGHGISCRYSPDGKWIVASGSEKDVYVYNSETMDQVATLPTGCGWNWDAIFSSEGRYIFTGGDDNQVKIWDVINSKKVAQWDGHGKPITAMCINGPTP
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MAANVQLWKTNVHIMTVKDACFVCFWTRVITFEQKPSLNQPSNSGEADLIRSREEAMSSELLGDVQHPLKRMRVEQSESAMPTFTNEDCTNEVPYPISEVCILGKAKTGVQIKEPGFVDVGSSLPFCHESQGNKLENGMEHTSQESVVLLADPGAGTMHGTQKLRGASLLEYFTPEQIRTHINSPRQFVGPTKSKAEQRQAMQNSSNQSRCQLCCMENLSFALAVYCNLCGLHVKRDAIYYITSNGGKQSYICPRCFRGARGESIEVEGFQVFKSNFVEKKNIDELNEEWVQCSGCGSWNHQICALFNNRSYSGQTEYVCPYCFLQEVEGGKRNPLPQSDLHSAKDLPMTILSDQLEQRLLRRLNWEREERAKVSGKNFDEVPGAKDLVIRVFLSVDKKLLVSQRFLEIVKDESYSSEFPYKSKVILLFQKIEGVDVVFFACTSKNMVRNVHIQTIVVSVFHILILSSTSSLRLSLLLGRLFVLLYIEKFCLEIPFVRRGRILLWFTCSMHESTVVNLKYPASSGFACCVKFFIFVRIVMRPNKMLIARIKFPVTEGESIPFLLFLIAMLLAILTTHINSLRVEMNDPSSSTEDKDVVMLTLADAMPEQWRNGKGI
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Basal body and ciliary axoneme.
Sequence:
MRLKISLLKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETSLIVKLPDDIYPIDLHWFPKSLGIKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWSKTGMLRSTLAQQGIPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRVLYGSQPHEHPITSVAWAPDGELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFAHVVEQRWEWKNFQVTLTKRRTMQVRNVLNDAVDLLEFRDRVIKASLNHAHLVVSTSLQCYVFSTKNWNTPLIFDLKEGTVSLILQAERHFLLVDGGGIYLHSYEGRFISSPKFPGMRTDILNAQTVSLSNDTIAIKDKADEKIIFLFEASTGKPLGDGKLLSHKNEISEVALDQKGLTNDRKIAFIDKNRDLYITSVKRFGKEEQIIKLGTMVHTLAWCDTCNILCGLQDTRFTVWYYPNAVYVDRDILPKTLYERDASEYSKNPHIVSFVGNQVTVRRADGSLVHISISPYPAILHEYVSSSKWEDAVRLCRFVKEQSLWACLAAMAVANRDMVTAEIAYAAVGEIDKVRYINAMKDLPSRESKMAHILMFSGNIQEAETILLQAGLVYQAIQININLYNWERALELAVKYKTHVDTVLAYRQKFLETFGKQETNKRYLQYAEGLQIDWEKIKAKIEMEITKERDRSSSGQSSKNTGLKP
The following text describes a protein:
Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MRYLVKHTKRYLKTSSHSLTTPPAPHWPYHIFNGLTQKLCHNPSFPPPPNLGGKYFPYKTLKPLSSLVILFSLPPGDFQTLTLVFFHLSSFAGIMLELRLVQGSLLKKVMESLKDLVTDANFDCSATGFSLQAMDSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLNNMSKMLKCAGNDDIITLKADDGSDTVTFMFESPTQDKIADFEMKLMDIDSEHLGIPEAEYHAIVRMPSSEFARICKDLSSIGDTVVISVTKEGVKFSTRGDIGTANVVCRQNTTVDKPEEATVIEMNEPVSLTFALRYMNSFTKATPLSSTVTISLSSELPVVVEYKIAEMGYIRFYLAPKIEEDEEDNKS
The following text describes a protein:
Function:
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVSLLVIRLELADHSRFPVGFQYCAATDMSDEEIKENALHNAAAHLEGKLPVDKTSILHQHIGRREMTDMIIETLSPSPDVNVSSAEKMDAALAVTNKTSLEEQGTCAMAVPDSPSKQLPEQITFFSGNPSVEIVHGLMHLYKTNKMTLLKEDVRRSAMLCILTVPAAMTSHDLMKFVASFNEVIDHMKIIRDSTPNQYMVLIKFSSQADADSFYMANNGRQFNSIEEDVCQLVYVERAEVLKSGDGASLPVMDLTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWEDTTCPVCRYCQTPEPVEENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGKIVQYECEGDTCQDEKIDSLQLEYSYLLTSQLESQRIYWENKIVRLEKDTAEEINNMKAKFKETIDKCDSFEHRLNDLSKEKQAVERRCAQLNSKVAKLSTELKEEQEMNKCLRANQTMLQGRLREEENTHKETSEQKDMQLLEMQEQLRDVMFYLETQQKINHMPADTRQEIQDGQINIASSSSPAPSGKLSSRKGRGKRGK
The following text describes a protein:
Function:
Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.
Sequence:
MTVATYEVEKQFLTYVKKIQNYGEALSLMFWDLRTGAPKKGVDQRSEVIGMLSSEVFAMSTSDEMGNYLTELEALIREDKLSETTKKMVVECRKEYDRNKKIPQAEYEAYVKLEAKAESVWEEAREKSDFEMFRPYLEKIVEFKKKFITYWGYETYKYNTLLDMYEPGITVEVLDHVFGQLRERIVPLVKEISESKKGLKTSALSEQFSKEKQKNFTLELLKQLNYDFEAGRLDETVHPFEITLNRGDVRITTRYDEKDFRMAVFGTIHECGHAVYEQNIAEQFEGTPLCSGTSMGIHESQSLFFENFIGRNKSFWKKNYDLLKEYSNGQFDDMSVDEFYNAINESKPSFIRIEADELTYPLHVMVRYELEKELFDGTLQVKDLPAAWNDKMEAYLGIRPENDAQGVLQDVHWAGGSFGYFPSYALGYMYAAQFKQRMLKDIPNFDALLEEGNVTPIREWLTEHIHQYGKTKKPLEILEDVTGEGLNANYLADYLEAKYKEIYEL
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity). Promotes expression. The PEAR proteins (e.g. DOF2.4, DOF5.1, DOF3.2, DOF1.1, DOF5.6 and DOF5.3) activate gene expression that promotes radial growth of protophloem sieve elements. Involved in the regulation of interfascicular cambium formation and vascular tissue development, particularly at a very early stage during inflorescence stem development; promotes both cambium activity and phloem specification, but prevents xylem specification.
Subcellular Localization:
Nucleus.
Sequence:
MGLTSLQVCMDSDWLQESESSGGSMLDSSTNSPSAADILAACSTRPQASAVAVAAAALMDGGRRLRPPHDHPQKCPRCESTHTKFCYYNNYSLSQPRYFCKTCRRYWTKGGTLRNIPVGGGCRKNKKPSSSNSSSSTSSGKKPSNIVTANTSDLMALAHSHQNYQHSPLGFSHFGGMMGSYSTPEHGNVGFLESKYGGLLSQSPRPIDFLDSKFDLMGVNNDNLVMVNHGSNGDHHHHHNHHMGLNHGVGLNNNNNNGGFNGISTGGNGNGGGLMDISTCQRLMLSNYDHHHYNHQEDHQRVATIMDVKPNPKLLSLDWQQDQCYSNGGGSGGAGKSDGGGYGNGGYINGLGSSWNGLMNGYGTSTKTNSLV
The following text describes a protein:
Function:
Component of a deubiquitination module (DUB module) that specifically deubiquinates monoubiquinated histone H2B (H2Bub). Does not seem to be a component of the TREX-2 complex. Seems to act independently of the SAGA multiprotein complex. The DUB module is responsible for the major H2Bub deubiquitinase activity in Arabidopsis.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Displays a rather patchy distribution forming a punctuated pattern in the euchromatin. Does not localize in the heterochromatic chromocenters or nucleolus.
Sequence:
MSARISFLKNPDPCNHLSDYKLRYGTDGYKSFNNLFRCFNDARIKIKLQGIDIPRCSYCSVYQKRLYICLICRSISCSSHILLHTQLNKGHDIAIDVERSELYCCACIDQVYDSEFDEVVVSKQLFGLGMSVKSGADVVAVRSNKKRRLDSQLIIGSNFLVSPRDRREKWTFPLGLRGLNNLGSTCFMNAVLQALVHAPPLRNFWLSGQHNRDLCPRRTMGLLCLPCDLDVIFSAMFSGDRTPYSPAHLLYSWWQHSTNLATYEQQDSHEFFISLLDRIHENEGKSKCLYQDNEECQCITHKAFSGLLRSDVTCTTCGSTSTTYDPFIDISLTLDSMNGFSPADCRKNRYSGGPSVNAIMPTLSGCLDFFTRSEKLGPDQKLNCQSCGEKRESSKQMSIRRLPLLLCLHVKRFEHSLTRKTSRKIDSYLQYPFRLNMSPYLSSSIIGKRFGNRIFAFDGEGEYDSSSSSSPSAEFEIFAVVTHKGMLESGHYVTYLRLKGLWYRCDDAWINEVEEEVVRGCECYMLFYAQETVIQKAHKELSYQVISMADAFPFADC
The following text describes a protein:
Function:
May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein.
Sequence:
MLGTLFGSAIGGALAVAGAPVALAAMGFTGTGIAAASIAAKMMSAAAIANGGGVAAGSLVATLQSAGVLGLSTSTNAILGAAGAAVGALL
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MEMDRLTRRQADRIEYVMRDLLRDLQLIAFLPVDLYPWTRRSCLEAARNLLAEASMNQGMNGAAAQIYGEDDNSTYVAQLIYGLAERYGDATDVDNNELLLQMTEFAELEREMLDTATSVGAVDEYDINRHHKLFRAVLDTLQQEGYTELVAHSLKWGSGDDSAVAQPPGAYPMEPSVFNRLVDPGMLSLQRTVECLCELLVVRNTSTVTEDIHNYKILHEAVNKEKSSSADVKALKREYHEIREARRTEVAALQAEVRQLEDEIEYTRSVLELELSAFGEANAKLEEERQVEEEERINALKEEAEHLKQKLDGLIAANQGEAATLRTQRAKKEAAVSAAITEYDTQMATLHAASVALNKETEEDTEAIVALDGELGALCTERNEYELEKYIEEMREKHYERMHEQTTRYASTIQACFRAYLTRVNFERGLANSKRKRKRKNK
The following text describes a protein:
Function:
Negatively regulates long-term potentiation and modulates adult synaptic plasticity. Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites. Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses.
Subcellular Localization:
Synapse. Synaptic cleft. Note=Detected in both the presynaptic and postsynaptic regions of the synapse and is secreted from neurons into the synaptic cleft. May be released by neuronal dense core vesicles which mediate the release of cleaved neuropeptides.
Sequence:
MAEGEGWRPPRPCEAYRAEWELCRSAGHFLRHYYVHGERPACGQWRRDLASCREWEERRSAEAQADSLPPGPEGEPRVAGAGPNAVTGILTRNQGTERPHGDTR
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase.
Sequence:
MGKRKTKEDNASEDYDANELMIVPGEKRKKLEKSGEKSATGGKKNRNFAKEKEVAKLTKQAKRKLAAVQSRKALKQTQEELFAGLAEFQLDPSKLCQLSSSTKLSKEPEKAPVFPEKLKVFSGKTKTEAKRTQQDYYPTDDESSSEEEEEEEEGDNDIEDAGNTVEVKIEPIDLDDVDEAIDGNPETNLDQIVVKREDDEESDNEDILALPTTTVINRKKVIVERSKEIQKSRAELPIFAEEMRIVEAINENLVTVVCGETGSGKTTQIPQFLYEAGYASEGELIGITEPRRVAAIAMAQRVGVELAKPDEVSYQIRYEGTRSETTNILFMTDGVLMKEMEQDVMLKKYSVILIDEAHERSMYSDVLIGMLSRIVPLRSKTARPLRLVIMSATLRLDDFTHKKLFPLLTPKVIKVDARQFPVSVHFEKRTPDDYIASAFRKTCRIHETLPPGAILVFVTGQHEVKQLITKLKKRYPVVYETDKNGEVLVKGTKEWKEKKVEAAKSIKLEDFKEETPETEDFEDVDDGLMDGDDMNERGAAEAFDDYEEFENGDGDLSDGKVENSIGAPPADCEPLYCLPLYSLLSMGKQRRVFDETPAGMRLCVISTNVAETSLTIPGVKYVIDGGFEKRRLYDSITGVSRFAVCRISQASGDQRAGRAGRISAGHAYRLYSSAVYQDFVKFADPEILSKPADQLVLHLKSMNIVKVVNFPFPSAPDEQMLESAEKRLCRLGALSESTKNGKTEARITKLGKTLAVFPLAPSYAKFIAMADQHNLMSHAILLISLLSVREPLIPVSSLRGDTPEETKELMKNVLKERRRWCSHTGARRLGDLKVLMHAASVAEQIKYNARECEKVGLRVKALVEARKLRQQLTNIVNASCKKEHAAALDSDLPPPTDQQAQLLRQMVVASFSDRLARRVDRSVGQEEVQKGAYETTLIKGHVFIDPCSVVFTEEPEFVIYQELVQVNEKKLMTSVCAVDKEWLSRLAESYCNYGEQDKNQEPIYDPVKDMVVKTVKVTFGPLNWELPNENRSVPHDIMMYRYFALFLLDGLVFEKLKEYTPKLLAPPSTMVKSWAKLQKRTEMLLNKLIEKEVTTRSSLKEQWLKNENWLLEEYLEWVPESVHQQISLMWPPLEDHEKTIKMGRNKKY
The following text describes a protein:
Function:
ABC transporter that may affect phytic acid transport and compartmentalization. May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAASERSLPCLFLHGASAGAHLILALAVAGSRLFPRRGKDTAVAVGGFPCYAVVVCATWALALFQLLLAAYSCYLDAGAGWPLDAVVDQADAATRAVAWLLLAAYLQFEFRREERFPAPLRLWWALFLLLSVVAVAVHVATSLDGLPVPARSWALDAVSVLAAVVLLVAGLSGKSEAGGSPSEEPLLDGASESSSAYASAYAGAGLLGVLTFSWMGPLLAVGHKKALGLDDVPGLDPGDSVAGLLPSFKANLETLAGDGTTSQRVTAFKLAKVLVRTFRWHVAVTALYALVYNVATYVGPYLIDSLVRYLNGGDERHARKGQLLVLAFIAAKVFECLSQQHSCFRLQQVGIRARSALVAVVYEKGLALSGRSRQTHSSGEMVNIVGVDADRVGNSSWYIHDLWLVPLQVSMAMFVLYSTLGLASLAALGATAAVMLVNVPSVKVQEKLQQNLMRSKDVRMKATSEILRNMRILKLQGWEMKFLSKIIALRKTETNWLKKYLYTSTMITFIFWSAPTFIAVVTFGACVLMGIPLESGKVLSALATLRVLQESIYNLPDRISAIIQTKVSLDRIASFLCLEEFPTDAVQKLPIGSSDVAIEVSNGCFSWDASPEMPTLKDLNFQARQGTRVAVCGTVGSGKSSLLSCILGEVPKLSGVVRTCGTIAYVSQSAWIQSGKVQENILFGKQMDSEKYDSVLELCSLKKDLESFPSGDQTFIGERGINLSGGQKQRVQIARALYQDADIYLFDDPFSAVDAHTGSHIFKECLLGALAQKTVVYVTHQLEFLPAADLILVIKDGIIAQSGRYNEILGSGEEFMELVGAHQDALATIDTIDVPIGASEAFSSGGAASLSGSLTSAEKKDKQNVKQDDGHDQSGQLVQEEERERGRVGFWVYWKYLTLAYGGALVPFVLLAQILFEVLHIASNYWMAWAAPASKDVEPPVSMYTLIYVYVALALGSSVCTFVRALFLVPAAYKTATLLFNKMHVSIFRAPMSFFDSTPSGRILNRASTDQSLVDTSIANRMGSIAFAFIQLGGTIVVMSQVAWQVFVVFIPVIAICLWYQRYYIDTARELQRMVGICKAPIIQHFVESITGSAIIRSFGKEKQFLATNNQLMDAYSRQKFYNAGAMEWLCFRMDMLSSLTFAISLIFLINLPTGIIDPGIAGLVVTYGLNLNIMQVTLVTSMCNLENKIISVERILQYLSLPEEAPLLMSEDGLAHNWPSEGEIQLHNLHVKYAPQLPFVLKGLTVTFPGGMKTGIVGRTGSGKSTLIQALFRIMDPTVGQITVDGVDICTIGLHDLRSRLSIIPQDPTMFDGTVRHNLDPLGEYTDNQIWEALDHCQLGDEVRRKELKLDSPVVENGENWSVGQRQLVCLGRVILRRTKILVLDEATASVDTATDNLIQKTLQQHFSGATVITIAHRITSVLHSDIVLLLDNGMAVEHQTPARLLEDKSSLFSKLVAEYTMRSTRT
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDTEGQPSESAVSEGVTNGDAIPSDFQDDAPVIQPPLSHHHQVASQSQQDDHCHCQQPLQAFWSGQLAEIKQTTNFKTHSLPLARIKKIMKADSNIPKRVAGEAPLLFAKACEMFIQELTLRAWLHTEEDMRRTLQKKDVTAALASTEVFDFLVADSSTDNKPKGNGEGLPPPTTAKDDDDSYGDYYWDDYSPPWSPEPPSPDLRNVTCDDPRYYTYIHDYYSL
The following text describes a protein:
Function:
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton.
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP