lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MSTNNILQYKEFSSFVNISFWHELSSKKLDVLKLNDEPIPLNSHYTFSPSQQLDPFLCLEFNGFQQTLKQSQQHKSHASNNNNENYYNVPNRSYLVPGTLLNYNTAEDFKQSPKTKLFEDASKKIWSDIVLGFVDKDMTLLNRFILITYADIKNHQFYYLFGIPALLPPQPIQQFEETKSLLQFYNKDQIKSTFMNNPVPQYFYLVGGSENEPFEIKNFEDSLTANEEYFKAHDGSREDNIPTVGFCDPCSLPSNPGWPLRNFLIYLIVKYQIKRVRVVCFRGVSLSSSEIETNSIVLSLTLPEIDGNITPEWSGKSVGWEKDNNGKIAPRFISLASTMDPLKLASQSVDLNLKLMRWRVMPSLNLEAIKDTKCLLLGSGTLGCNVARCLMSWGVRNITFVDSSKVSYSNPVRQSLFTFDDCTPKNKEKSVAAAEALKKIFPAVNAKAEVFSIPMPGHSVPKHEHDNVKATFEKLEQLIKEHDVVYLLTDSRESRWLPTLLCRANNKLLINAALGFDSYLVIRHGIRNALSQKESDDGCDLGCYFCNDVIAPTDTLKDRTLDQMCTVTRPGLSMIASSIAVELLISTLHHPLGGRAPAETDTDVYKQASTPLGIVPHQLRGFLSHYQTLPLFSNPYKNCTACSDFIVNEFNQNGFNFILNVMNDSSILTKVAGIDELKNSEVTIDWDLDDILSDDE
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLLDLNRFSFPVFLKEVRLLTTLALPMLLAQVAQVGIGFVDTVMAGGAGKEDLAAVALGSSAFATVYITFMGIMAALNPMIAQLYGAGKTDEVGETGRQGIWFGLFLGVFGMVLMWAAITPFRNWLTLSDYVEGTMAQYMLFTSLAMPAAMVHRALHAYTSSLNRPRLIMLVSFAAFVLNVPLNYIFVYGKFGMPALGGAGCGLATMAVFWFSALALWIYIAKENFFRPFGLTAKFGKPDWAVFKQIWKIGAPIGLSYFLEASAFSFIVFLIAPFGEDYVAAQQVGISLSGILYMIPQSVGSAGTVRIGFSLGRREFSRARYISGVSLVLGWMLAVITVLSLVLFRSPLVSMYNNDPAVLSIAATVLLFAGLFQPADFTQCIASYALRGYKVTKVPMFIHAAAFWGCGLLPGYLLAYRFNMGIYGFWTALIASLTIAAIALVWCLELCSREMVRSHKAV
The following text describes a protein:
Function:
Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer.
Sequence:
MNKHERLDEIAKLVNKKGTIRTNEIVEGLNVSDMTVRRDLIELENKGILTKIHGGARSNSTFQYKEISHKEKHTRQIAEKRFIAKKAASLIEDGDTLFFGPGTTVELLAEEVNHHTLTIITNCLPVYKILLEKQTAHFRVYLIGGEMRHITEAFVGEMANAMLEKLRFSKMFFSSNAVNKGAVMTSTLDEAYTQQLALSNSIEKYLLIDHTKVGKEDFTSFCQLNELTAVVMDYEDEEKVETIKTYIEVVD
The following text describes a protein:
Function:
Styrene monooxygenase which catalyzes the first step in the aerobic styrene degradation pathway by enantioselective epoxidation of the vinyl side chain. In a two-component system, StyB reductase utilizes NADH to reduce FAD, which is then transferred to the oxygenase; the electron transfer is proposed to occur via a diffusing flavin.
Sequence:
MKKRIGIVGAGTAGLHLGLFLRQHDVDVTVYTDRKPDEYSGLRLLNTVAHHAVTVQREVALDVNEWPSEEFGYFGHYYYVGGSQPMRFYGDLKAPSRAVDYRLYQPMLMRALEARGGKSCYDDVSTEDLEGLSEQYDLLVVCTGKNALGKVFEKQSENSPFEKPQRALCVGLFKGIKEAPIRAVTMSFSPGHGELIEIPTLSFNGMSTALVLENHIGSDLEVLAHTKYDDDPRAFLDLMLEKLRKHHPSVAERIDPAEFDLANSSLDILQGGVVPAFRDGHATLSNGKTIIGLGDVQATVDPVLGQGANMASHAAWILGEEILAHSVYDLRFSEHLERRRQDRVLCATRWTNFILSALSALPPEFLAFLQILSQSREMADEFTDNFNYPERQWDRFSSPERIGQWCNQYAPTIAA
The following text describes a protein:
Function:
Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Also converts S-methylmethionine (SMM) to methionine.
Miscellaneous:
MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRIPIKELIVEHPGKVLILDGGQGTELENRGININSPVWSAAPFTSESFWEPSSQERKVVEEMYRDFMIAGANILMTITYQANFQSISENTSIKTLAAYKRFLDKIVSFTREFIGEERYLIGSIGPWAAHVSCEYTGDYGPHPENIDYYGFFKPQLENFNQNRDIDLIGFETIPNFHELKAILSWDEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGNKINKNLLLMGVNCVSFNQSALILKMLHEHLPGMPLLVYPNSGEIYNPKEKTWHRPTNKLDDWETTVKKFVDNGARIIGGCCRTSPKDIAEIASAVDKYS
The following text describes a protein:
Function:
This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIAAQAVECIARQPESEGKIQGTLLLSLVFMEVLTIYGLVEALALLFANHFV
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Also regulates the sphingolipid metabolism. Required for growth during anaerobiosis and sterol uptake.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MICITCMRPVDSLYTVYSNDHIQLTDCPYCQETVDKYVEIDNVLLFIDLLLLKAGAYRHLVFNALELHLSKYPKRKALNDCQCLRDYTQALLFNVKNWFCKYDRLNRLWLLLLSFEIYLTWVTEESKYIYYLNRNNNDGKLIMLSKKLPESFKWDSAIMRNTITSKVFTWSPPIQYLYFASYCILDVSLFHTFTQYFILKKLHWKHYSVSSKDVISYTILLSYGAKIFPILMLIWPYDTLISMSIIKWVANLYIIESLKIVTNLSYWNIIKIFISVSLLRYFMVKPILIVFVAKFNFSVIKNLIHQEFILLLQKSGTYLLL
The following text describes a protein:
Function:
Transcriptional repressor for the ars operon.
Sequence:
MDETKSELLRKYEQKFKALADQKRLEIMYELCQRGKTCVCDLTEIFEVTQSKLSYHLKILLDANLITKETKGTWSYYDLNDEEVNGLLSEELCCIFRKKGEGDCC
The following text describes a protein:
Function:
Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Subcellular Localization:
Secreted.
Sequence:
MKSTCYMIGILLLILQNTYQSPVPEADGSSRSVKAARNEAVDDSEQLKEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRSGGLSRRNADYERHAEGTFTSDVTQHLDEKAAKEFIDWLINGGPTKEIISRRNAEIERHAEGTYTNDVTEYLEEKATKAFIEWLIKGKPKKIRYSRHAEGTFTNDMTNYLEEKAAKEFVGWLINGRPKRKDLLEEH
The following text describes a protein:
Function:
Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism. Provides the link between the first step in H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate. The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor.
Miscellaneous:
MISCELLANEOUS: Present with 7470 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MWKAVMNAWNGTESQSKNVSNIQSYSFEDMKRIVGKHDPNVVLVDVREPSEYSIVHIPASINVPYRSHPDAFALDPLEFEKQIGIPKPDSAKELIFYCASGKRGGEAQKVASSHGYSNTSLYPGSMNDWVSHGGDKLDL
The following text describes a protein:
Function:
May play a role in transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEESQNIPPKTQTLNNSENSINNINNNNLTTTTTTTAVGNTNYKNNNRYNNNRYNRNNFNNYNNNNNNNNNNNNMVTSTTSPPTTTTTTTSTTTTATPSSNSNNRRKNYHNNNYNNNNNNNQLSEDTDEVILYTPADISASLKSESAKQQQQQQQQSLPTQEPTQTLNWQQELYKLNPKSKAFVPKPQGSVPFNNTNNNNNNNNNNNNNVPQSPIKDNNRPQRERRERKPKENNTQQPQPQQPQQPQQPQPQPQQQQQSQQQQTVKENNRKKENKLQSKKDIITNNDNIEPIKSKEDISLANKFAKNRAKENLAKTNSINNSNTANSNKIKGKTKFIFNENDEKNSEYTPLAIQMITKIQANIYECMVCFENVGKNAVIWSCSQCFTMFHSSCIKQWSSKSVTTEGKWKCPGCRYNHEVKPEHFQPACFCGKVKDPQYNPYHLAHSCGEVCGKLRAKSNCPHSCTMLCHPGPCLNCSSLGDIKDCYCGKTKYRLLCGEVDKGKVCEGKCEKLLSCGNHRCQQQCHSGSCSPCEVVETQKCYCGKHIDKTKPCGSGSIDTSQSDDDPRFFSCAEKCDRTLDCGNHKCQRTCHKGDCEPCSLVPDRVDRCNCKQTTLEELGVVRTSCLDPIPVCKKVCSTLLACKQHSCTDRCHTGPCGSCKVKVRSICRCGKTTENRQCGVIQQNMSSTSAAAFTCGNVCKILRSCKRHECGVKCCPSTSSSDEAGNHVCTLVCGKQLKCGVHKCQQLCHSGKCYNCYINSYDDLACPCGKTVIQPPVPCGTKPPMCNHPCTIKRECGHSNEVWEHKCHSGPCPPCTYLVDKMCAGGHQVQKSVKCSTIDASCGRICGKVLSCLSHTCPRICHSGPCLINNNNVNINKQQPLLPANLIASKNNYQLQQQSKLPTTTTTTTTTTSTTSTTSPKIIEKDEELIEDDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEKAEITNECNHDHDHEHEHSDDENSEEEVDLNECNHNHECNEEEERIKKEEKEDDEDEDELFDSLMGNLTCGYLCGIPLKSCEHTCHQACHPGEPCPTNISCKQKVRIYCKCKRRSVETLCCGKDDTRQLECDEVCEKEEREKQLKEAFYGSHTLDNNPNNPNNPNNPNNNTTTTTTTTTTTTSSPTNFTVLDPTSIDYQPNKLQIEALQLIAKASPKLIKKIEAIYEDFINSNLLKQTIKYTDSIQLFLLVQMAKFYQMKYREKKPLNYIEFFKKTSYQIPSPRLSEMVGINGSSLSSGTISNSLSFSINNGQSYASISLSPSEMVAQAQAQAELENQCPALLFKNLDPSIKTDHLTNLLQEFEGRYKLMWVDDSNCLAIFGDSISFSMASQIKTMFTYEIYQDDPSLIDITFGNSVLSTPTSSSGSNSGVSSPLSYLSPLKKSQDTQFFRVSQQMNKFSFLDTINQNQNQNNNNNNNNNNNNNSNINIKPTIPLYSTSTANANRMLRRSNENTGENVADDWENL
The following text describes a protein:
Function:
RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGAFTHMGNHLVSDSAATINAGAGDDESILDHGLTGSRRRRIGEEDDETDIYDDDDMESMASMPVGGANGKPAMRAEEEVELPAHACAYCGIHNAGSVVKCLACTKWFCSARGNSSSSHIINHLVRARHKEVQLHPASSLGDTTLECYNCGTKNVFLLGFIPAKSDTVVVLLCRQPCASMPSQKDMNWDTSRWQPLIEDRSFLPWLVPAPTDQEQLRARHLSPQTIAKLEELWKDNANATIADLEKGAGQEEVIAKVLLRYDDAFQYQNVFGPLVKIEADYDRKLKESQSQDNLVVRWDMALNNKHTASFILPKLELGDVKLAVGDEMRLRYTGELRPHWEGVGYVIKIPNNQSDEVTIELRTKGDHKSVPTECTHNFSADYVWKATSFDRMQHAMKTFAIDEMSVSGYIFHRLLGHEVASAPMKIQIPRKFSVPGLPELNGSQINAVKSVLQKPLSLIQGPPGTGKTVTSATIIYHLCKISASQVLVCAPSNVAVDQLCERIHLTGLKTVRVTAKSREDVESPVGFLSLHEQVRMNDTNVELNKLNQLKSDVGELSSQDEKKFKQLTRAAEREILNAADVICCTCVGAGDPRLSKMKFRTVLIDESTQSAEPECMIPLVLGCKQVVLVGDHQQLGPVIMNKKAATAGLNQSLFERLVILGCSPIRLQVQYRMHPCLSEFPSNMFYEGSLQNGVTMQERIRRDVDFPWPVADSPMMFWSNLGAEEISASGTSYLNRTEAQNVEKIVTRFFKAGVQPGDIGIITPYEGQRSYVVSSMQATGSFKKENYKDVEVASVDAFQGREKDFIILSCVRSNDHQGIGFLSDPRRLNVALTRAKYGLVILGNPKVLSKHPLWHYLLLHFKERNCLVEGPLTNLQVSLLQFSRPKQTYRGPQRYQMAYQHANAMTSGRQGSWSGNKPTRQEYNDNGSIVGYIPDDVSSVHSSALGGVGVPSNYPPMFSNFQESWPLPGRPGSGAKGRNGAPASVAGESVAASELTDSRSDAPGGISLSGLSLNDYNKPTSLSQSDRLNRFVESTRQGPALGAGFGAGRGGLRNGLGGFDDDDARSVSTAFASQIGG
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Sequence:
MSPSILGRKIGMTQIFLEDGTAVPVTVVQAGPCHVLQVRSKDRDGYEAVQMGFEDKPRRLAKRSERGQVATIESKRSKKRSAAGIEAPAKADCEPQRFVREFRGSSEANVGDTLTVEQFNDVKKVDITGTSKGRGFAGVMKRHNFAGQRATHGVKKCHRHAGGTGMSASPSRTFKGKRMAGQYGNAKVTTRNLEVVRVDAENNLLMIRGAVPGPNGGFVSIRQTNKVG
The following text describes a protein:
Function:
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Subcellular Localization:
Nucleus.
Sequence:
MKMGVKSDGVKAWLRSRHISVLGEWVEACMEWIQEEHQGTVLSGSQLCKMVYEQWLDSELTEIATPCLPAGIKQAKKTQLKGNYALQVNCIQDISSPAYAQLTKLQGRENENDSVTAVPATQGKFEPPSSRMLMLSLTDGQETIQAMEYRPVPGFTANLNPGAKIMLSGDMQCRLGVILLTPAHVKVLGGEVEALKEANSQEKMLARAIGVTPPDRPVGSNNRGQGTTATVTTTTGQTTTTTNNTTTAPVQNQPVTTIQRQQSNQHKTLPRDTSHKAPVKQEPRVNTPTEQRWNQGHIRQISDTKQGVHHGFNQGHSRSNQDTKPTGHHGWNQGPSRSVQDTKPVGHQGFQDPFLVDDDDGLDELMLEELENLEKQEAQKVKPEPELSHQDWDVEDIDEEDLLAMEWESSNKQMQNGQRQNNPREQPYQRHSTAVRSSSNLQENRGGSSIKPFSSVSHSLPGSERTKIPPVKTQLPKASNTSPTFASNVVPLFKREMKPPSASRISQGPQRTELCVVQPINSTRTQHVKHGDQHSFGRADRGVQLPVNTKIAVATRIMKAESVSQQGHGDVVQGAVGKTDVGSISEGSERRDFVSAQSLVKSEEGENAPKRMRIHSGPKCTRPFIYLTKMADQLKRKEACRFDIKGFIMTLVSSLSHNPSWSLAAKINDGTMSLDVDISDKVLSKMIGFTVAEMMEMKASMKKSEKEKANEIKESIKQGIGRCQQALIDLSCIMTIEVNPEYPRPLVIAVRQPTMDDCNALRRCLEESQWFACMKR
The following text describes a protein:
Function:
May be involved in splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPKRGNRRRRGGTGGSGGGRGGRGGSRGRGGGRRTPSGANRGRHPSRGNKNRSPRTITQYGDLMDDDNIFIPKTMSEVASNMGRRKYGGMFEEIEYTESHQEDLMSRQLRNRPVEFVKAKEVYDPNVILYKLAKLNNKDDGIDIAVQSISLDDSENESSTNKVDISSSEEIEESGDEYEDEQDDEDDWDEEELHNEITTKLEALEEAMNNVSSDTESEQSVSHIEEEDEKVESHIPEPDLSAEVDEPLQEIDESENENQMESEVGTNTNTQDIETLDIIIDLPSNKVESHMSHSLPQKFKTPSSPDDDNDDNNNNSTPESEPEYGYLEEDYEFDVSKIEVSNVRFGIENQYHIKCMELTGSIDEYIWIDENDVIEYVLDNGVKEHRLNKFLSFITKGMIDEQEPEPEPEVYISDSNSEEEEEEEDDYNSEQDDYPYDSDDNLEDLIAYSKTSTQGLIPFEDRDFSNNIPSKKRQTFDHLDFDDDGELQDSLIRQLNNYKANKKLKKHQWEQQKLEESILHHDMLIKYPVSLHIKDIKSEFDQLLKDESRQSMSFPTLDTHGHKTIKNLADCYHMSVIKSGKQGIRKYLKIVKNKATFKYYPNYERINRILRGRPIFHRIDQKPQHKKGEKSKSKSSRGDASSSRARFKEGDIVGAEAPEIGSSNLGRQMLEKLGWIQGQGLGVDGNKGINEPILAKVKTSKTGIK
The following text describes a protein:
Function:
Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MEASEKKRKRTVISERGFSGAIGGSLTRAMCQPFDVLKIRFQVQIEPISKTNSSAVYRGIFQGLQHIVKSEGWTALWKGHVAAQALSATFGFVQFGLFEGITTYAFEKSPALNSVQSGVNFSAGFGSGCLATIISFPFDTIRTRLIVQGEPKIYKGVIDVVSKMWANEGALSLYHGLSPTLIQMGPYIGCQFAMYKFLVEIYDQAMEEKSAGLKSLTCGAVAGAFAKTLVYPLDLGKKRMQLQGFCDRHQYKGLFDCLATTVRNEGLAALLKGLSPSLLKAVFSSALQFYFYEITLEFLTRSRFEYIQK
The following text describes a protein:
Function:
Critical regulator of angiogenesis and endothelial cell (EC) migration. Promotes the migration of endothelial cells, which is essential for angiogenesis. Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope. This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development. Involved in nuclear movement during fibroblast polarization and migration. May recruit Ran GTPase to the nuclear periphery.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHTVVNCWFCNQDTVVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYLEHLNHVVSGSPGPRAPAQPLQWVSSQVLLCRRCSHHQTAKVKQLAAFSPRDEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEHYIKHQNRQLRALLLSHQFKRREADQTHTQSFCASAVKAPAQVIVLRALAFLACAFLLTTALYGTSNPFAPGAPLPPTLPTGSNGSAPPDNGTATGAEGWRQLLGLLPEHAAEKLREAWAFGQSHQMGVVALGLLTCLLAMLLAGRIRLRRIDAFSTGLWALLLGLHLAEQYLQAASPSWLDTLKFSTTSLCCLVGFTAAVATRKATGPRRFRPRRSEKQQ
The following text describes a protein:
Function:
Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA.
Domain:
Contains a pseudo-FCL region, a large solvent-exposed peptide region containing an alpha helix and loop anchored on each end via ligation of two cysteine thiolates to a [4Fe-4S](2+) cluster. This region is involved in DNA binding and catalysis, particularly in duplex DNA contexts.
Sequence:
MESLDDIVREIMSCRKCDLHKTKTNYVPGVGNEKAEIVFVGEAPGRDEDLKGEPFVGAAGKLLTEMLASIGLRREDVYITNVLKCRPPNNRDPTPEEVEKCGDYLVRQLEAIRPNVIVCLGRFAAQFIFNLFDLEFTTISRVKGKVYEVERWGKKVKVIAIYHPAAVLYRPQLREEYESDFKKIGELCGKKQPTLFDYL
The following text describes a protein:
Function:
Probably participates in a plant defense mechanism (By similarity). Has cytotoxic activity against HUVEC cells (LC(50)= 1.83 uM) and various cancer cells including HeLa (LC(50)= 1.81 uM), MCF-7 and K562. Displays very weak hemolytic activity.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
SIPCAESCVWIPCTVTALLGCSCSDKVCYN
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MPATPGRRSSRAQDFRLPGVTREDSDDELGTDDLPWEWIYDREEDEGENEVIPASGPGSRKRKRTTQPERKIIGAQMGDFDCYVGDTLLLKAEGSNEAWVGIVSEFLVDDGEKSAKFMWFSSEKEIRNGPKKRTDFVENELYITPSFDFNALTTINGKAIVMSQEAFMKQYPTGKVPRKSKEFGKVFICRRGCNTRTCTYTDEFKWEDIYKGKEDLESLLDFVLKRTKATRRKRQPKAESPEREYASDDGAGAEPAAKVPRTPRKLKVRSNAATPTSRRKGTKAALSAAVTPTSHRKIMIKRHLEFTPLATRVLSPMHIHNSPYQLARTQLHVASVPTSLPCREAEFSLVYSHLEAAITDGSGTCIYISGTPGTGKTATVREVVSHLDAAVRADELDDFIFVEINGMKITDPHQSYSLLWEALKGQRVSPSQALDLLEREFSHPSPRRVPCVVLMDELDQLVTKNQGVMYNFFNWPGLRHSRLIVLAVANTMDLPERTLSNKISSRLGLTRITFPGYNHEQLMRIVQSRLEGVPGDIVDADAVQFAARKVAAVSGDARRALDICRRAVELAEADAKVVAEAEPPTPSKKKGVEDKVVSKKKGSAGRVTIETVRRAINEATSNPLQQYLRGLPFASRLLLTALLLRTQRTGLAESTFGDVLEEMQRMIKLATGGDSRPLNALMATAGVSAADYGDGIMGGPRSKPDVRQMRPGGLAIAAVDLTGAGVINLEAHKAERPSKIRLAVGDEEVRLAFRDDPEIKTLGVLL
The following text describes a protein:
Function:
Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MIFPISEIPDKVTHSILEGVSALQNMSHTAFWSTVLGFLVVARIAVILATPKRRVLDIKGKKVVISGGSQGAGAALAELCYTKGANVVIVSRTVSKLEAQVQKIVTKHEPVFEGQTIRYISADLTKEEEAIRVFSEETMPAPPDVIFSCAGAAETGFILDFKASQLARAFSTNYLSALFFVHAGTTRMAKEPISPKNPRYVAIFSSVLAFYPLLGYGQYCASKAAVRSLIDSLRVEALPFNIRVVGVFPGNFQSEGFEEENKSKPEITRQIEGPSQAISAEECAKIVFAQMEKGGQMITTDLIGWILQSIALSSSPRSFSLLQIPLAIFMCIFSPVWNAFVNRDVRKYFHANTEYVTRHQRGGVGSENPTPQ
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MVQSTFKRFVEVGRVVLVNEGPSAGKLAVIVEIIDHNRALIDGPTTSVSRQAFPYRNLILTPYTIASLPRGVGAGPLKKAIEKAGVSEKWEQSGWAKKLAARQVRKNATDFDRFQIQLAKRARRDVVRKAYVKEKKASA
The following text describes a protein:
Function:
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres.
Miscellaneous:
MISCELLANEOUS: Present with 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKTNKKISKRRSLKNLHGALKGLLKESGKKSESKIRKHSDCNPVHRVYPPNIEKRKTKKDDGISRPIAERNGHVYIMSKENHIIPKLTDDEVMERHKLADENMRKVWSNIISKYESIEEQGDLVDLKTGEIVEDNGHIKTLTANNSTKDKRTKYTSVLRDIIDISDEEDGDKNDEYTLWANDSEASDSEVDADNDTEEEKDEKLIDADFKKYEAKLSKRILRD
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDLPPLSLDQLSAVITAGPTPTDLYTSLSAYEEQACLLSATDPSEKDLLLEFYTAFFFSHLLTDQICEARALTRRIPREISRLDAMQTCSLLLRAVWQSKHTEIYKILRELPWPGRSQPLVQRYESYFQEKTLVEMSNSYETIRIAAAATYLGLDPAAVEGDIIEKFTACGWKWDSEKQLLHPKPVVTAPPKDDSLQNELSRVMALISNQGS
The following text describes a protein:
Function:
Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling.
Subcellular Localization:
Cytoplasm.
Domain:
The specificity for linear polyubiquitin is given by the 'Glu-16' residue in ubiquitin chain; The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31. Does not interact with other PUB domain-containing proteins. Phosphorylation at Tyr-56 prevents interaction with RNF31.
Sequence:
MSRGTMPQPEAWPGASCAETPAREAAATARDGGKAAASGQPRPEMQCPAEHEEDMYRAADEIEKEKELLIHERGASEPRLSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPEKLISKYNWIKQWKLGLKFDGKNEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNRAIELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVYPTDPPKDWPVVTLIAEDDRHYNIPVRVCEETSL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MALGVFPNLRFISFSILSLPGNELSLIPSIPASEVIVREIKEEIPETDISGQAEPRWTLLAAPPGTVPLNAEMRRGLQRQWDPQPGHMWREPPRHLRAANSKRSMFHVGRKKLMCPECDRWFHCKSEFLLHWRTHTGEKPYECLACGKRFIQSSHLSAHRRIHTGEKPYECPKCGRSFNRRSTLTEHLRIHTGEKPYKCLQCGESFRWRPYLTKHQRIHLVGNPTYKGLENGEAMTESSSPGEQQEVLTDSDPVRNGTAETNSHHAASELVMQHDRVMLNAETQVVKQDLETHPLEKPIKTEAAALPEGNDVTDVSQLKIVQVEKKHVCHECGKAFQYKFELVKHHRTHTGEKPFECLACGKRFFQSTHLNAHLRIHTGEKPYECPKCGRSFNRRSTLTEHLRIHTGEKPYKCLQCGESFRWRPYLTKHQRTHLGDNAYKYFDSGESLYDSSSFPEHPDGNHPGGGNVRESSPIVQM
The following text describes a protein:
Function:
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors. Required for resistance to cationic antimicrobial peptides (CAMPs). Modifications of lipid A with an acyl chain to evade host immune defenses by resisting antibody-mediated complement lysis during respiratory infection.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MTQYFRALAFFLLLVPATAMACDGWPSWARGACQRVDQIWNEGGNDLYLTGYSWHNRAMYSSDKIRSFNELAWGGGLGKSIYDEDGDWQGLYAMAFLDSHSDIEPIAGYGFQKIGRIGADTRLGIGYTVFLTSRSDIMSRVPFPGILPLVSAGYRDATLYATYIPGGKGNGNVLFMFGRWEF
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MAHLEMFPCMDEIKEEVQKIHQVRIGDASASIARSVAASDEVDKLFNVAITFNRNACALFQSMSAFFSRDNVALPGVSLFFKVISQVETNDSLLIMDFMAKRGAKVEFGPTAAPPSGWMTHKEGSDVVVAFAKTLAVFKVQYKKLNDHYLLAQKSGDAHAQSFIGSCMNAVIDWWSEKIRVVSHHLTHLKLVESDKHAIKEFDRRLPFELEDYAMAAAVESIIPSR
The following text describes a protein:
Function:
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
Subcellular Localization:
Cytoplasm.
Sequence:
MHRRERKVIYPSYFDSRLSRKDGRRVPRSLAIRGPTLQDLINALKSLSMSFDVERDKGRPSRWYKFEGRVLVHYEGKKEELLKILAEEMVRQRREISGRSGQGN
The following text describes a protein:
Function:
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built; The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MTGLEKQRVEAKFFDLDEIIAKSESTSCTFDMAELDPGFFQEMMGISKPTQNGDGYGADAPLWLLESMRTPFTIHLPQAFSVNMQGVLNADSRTVNLARMQQQFYTNGMQLCHLMKEHNAEGALNLAKCLLSTLTQRLGGILSNSTHQRTKGEKFDCLETKVFLEGRRCKEDIDQWLRQDNKGTSKKRKRESF
The following text describes a protein:
Function:
Enhances the phosphorylation and activation of AKT1 and AKT2.
Miscellaneous:
MISCELLANEOUS: Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.
Sequence:
MASEASVRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRREWARASQGSRYEPSITVHLWQMAVHTRELLSSGQMPFSQLPAVWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVLTYQPERKD
The following text describes a protein:
Function:
Plays an important role in the synthesis of 18S rRNA but is not required for the 5.8S and 25S pathway. Is necessary for the cleavage at site A2 (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MDKLKEKGFVKLEIYLENKKRLHSIFLKEDTEDVEKKSLYLINVPITTTEKILKRAISQLGGRIVNIYPNISGLLKSGTHLRVKLVEPAEVKQVIKAASKKTTSLPWKFTQHTGLKRYVESYDRQFVNPRVLAESVDSYMKRVTKKEIAEKRRLFAMKNQPDEDGFVTVVRSGRAPVGRPQDAERQLEKKKDTGIHKDFYRFQLREKKKKALLDLAHKFEFDKQRIQQLKEKRQFKPY