lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit polr2a, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin and transcription pause-release checkpoint.
Sequence:
MLITFVVDTSGSMSQKTTNGMTLLDCSKAAIEHFIKIRSKDASMRNDRFFLITSEENPITAVKIGWKDNFNSFIQEVKNLQTKDMSNLGFSLQKSFDFLNQFRVQSSIDNYGQGRNPWFIEPAIIILLTDGSSLTNSSSIIENFTLPKTQFHLNSDPTSEPFRWDQRLFSIVLKFGGISSNKSLPLPMEPAIAPMCDVTGGRCQVATNMKTMIQQVEGLMQKLQGGVVVSFEPLVNQQQAQAQAQQLLPPPPLSLHKMLYVRQQVGFWPIPEGYYPDITSLSLPMRLAHPVIRYSIIEADTHIPENFPFDKYELEPCPLTQYLLTNKIQCTHVFMMNSLQVSGQGEPFGCLRLNSAGNSVNLFVFPYNFPRLWILLEDLTTTFKMMPSQKWKQEFEGYLLSIPPYYINPLRGALKRFCSLNLIPDNIDSQFINFINNTIKKIKSQSISKMESERIINSKQQQQQQQQFSHQQQFQQFQQKQAQQYDSSPSSPSSSPSSSSSNTSGIGSSSGSGNLATKKKSFHQILDQGYSSDILSELIQQDNETSENSELSQELSESSTTGSSGGGSSSNINILQRNVFDIGRVQLLNQLDKMKDHIFKKKIQKDESKHHLPISQMGNYHETIGKRETLRDIDDDKKPNTPLFGNPYRKEKSNQRYMSIDEADEGGNLTSDGEGKNKLTPNKRRRLSGRGYPSLPTLNSLSNTSTTTSTTTTTTTTTPATSTNTTITSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTITSSPPTTSTNPLLQPTTASITTSTVPIPSTTVSSPITNTSIITTNIHIQPTQISSPPPLSSSLAINQPTQTSSVISSSSSPPPPPPPPPLPIVNNNNVIPSSLVQVTNNNNNIPTVPVNNISPPTSTISSPNNQHLLPTPPNINNTSISTTNVPNISTTTSNESIISQPISPTHKNIAGVVRPFRPNSPPLTIDTLTSSSSSSTIPTTTNGSLSTHDTPNTSPTLSSINYNNNNNNNNNNNNNNNNNNNNNNNNNNRKNSIITTTTPNNETNNIIKFVHKEIRRPTKDNHDIIIQQLSKLFSILSDGNLRLKLLKDTINLAKEYKKSSLISKLIGYIDQIK
The following text describes a protein:
Function:
Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLQRLSQSIKGFAARFPKIYNKGNGSVQQTILQASQRLNELTGYSSIEALKNAVVKQETKLRDFRLSAAEARKRYIEAVEKRSSSQREVNELLQRRSSWSTIDLERFTKLYRDDYSNKEEEIKAQEDVDVAERRVEEAQNGLVRSILSRYHEEQVWSDKIRQASTWGTWGLMGINVVLFVVVQLILEPRKRKRLVREAVDHIDKERELEINDELKKISEKLDKKGEAVGQALELTSPKIDNKNLPKNSASLILPPINYDTFHSFLDSLKYFLSRFLSTDYRIQLTYRQLSILATKFTVGGGVIIYTFIHLFGLAFKR
The following text describes a protein:
Function:
Involved in cell division, cell envelope biogenesis and cell shape maintenance. Is a key regulator of cell envelope growth, playing a crucial role in coordinating cell width, elongation and division to maintain cell envelope integrity. Plays an important role in the lipopolysaccharide (LPS) assembly/transport. It may regulate LpxC levels and assist MsbA-mediated LPS transport.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MTWEYALIGLVVGIIIGAVAMRFGNRKLRQQQALQYELEKNKAELDEYREELVSHFARSAELLDTMAHDYRQLYQHMAKSSSSLLPELSAEANPFRNRLAESEASNDQAPVQMPRDYSEGASGLLRTGAKRD
The following text describes a protein:
Function:
Binds tetrapyrroles and promotes the photooxidative degradation of protoporphyrin IX. May play a role in the transmembrane transport of tetrapyrroles and similar compounds (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNILKLVASILAVLAIGFAGSFFTAQSVQTWYAGVEKPFFTPPNWLFGPAWTLLYFLIGIVLYIAWENGFWNDSRVKATFFTQLGLNFLWSILFFGLQNPLAGLVDIIALDIAVILTIVYIYHHSKASLLLLPYLGWILFASALNFAIYLLNA
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSNAPPGRAKPDSGRSGRGARGTVGRVTVPPAAPDPNAPPQGPASPAPAPSPVPKKSLQANTLIVMAGTLGSRLSGIVRQQVINLFDTTLTDAFNVAIKVPNLMRELLAEGALVNSFIPVYKTLDAAERRKLAQSFSGFLIAINLLLMALGIFAAPWVVGLLTSTHANIDRAIAIYMTQLVMPFLTLISLSAVAMGLLNADEHFRESSFAPVAFNIASIIALLLLPNNATWLAFGWLIGGVAQLLVQLPALRRFGLLPEPRLGGHPALGRVLKQMAPFTLTAGARQFLNLYVTRLLTDASQFKPGTQTGYANAEALFTMANGLFVVSPALAVFPRFSQHAAEGNWNEFRSLTAQTIRTSTFLAAPVSALLLVLAPYAVSVYNLKSGFDPNRFEAGSGILAGWALALIPWALVTILLRTFYARERTREAVTVSAIGFVLEVGLYRLLVPAFGLFGFGLSTTLSGILMAFALMLMYQRALGFPWQAVGDHLARVVPLALLSGIVAWLISRVMPAPGFFLPGLFGLAVAGGAGLLVYLLGATLLKMPEMAGLLRRLKR
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Sequence:
MITGYSTPSAHVLMSSRAFKSSSYRAAAGQTQHYLARSSLPVVKNSWGSPPSPFNELPRVSRGVPLSYLSASSSLLLNGEQGSLSGTLPVLPVRRKTLLTPRASKDVPSSFRFPPMTKKPQWWWRTLACLPYLMPLHETWMYAETAYHLHPFLEDFEFLTYPFLGAIGRLPSWFLMAYFFVAYLGIVRRKEWPHFFRFHVVMGMLLEIALQVIGTVSKWMPLGVYWGKFGMHFWTAVAFAYLFTVLESIRCALADSVCEECKQNPWKYKCPGCSIRSCALPCVKAHKQRTGCTGKRKFTDVVPLSKFDDNLLLSDYNMLEETKRVAESALRRRSQLCKNHYSYKLPYLLKSLQSAAYSRRTKLWYLPSGMLKRENNQSRYDNRSKCISWTIEWRFHSTDVILVDHGVGEDRNLCSVIKNHLKPGPWIHKLKPFCDVDLDSLKLFIRQYPKGAKAPFKELDIKAPLRKQLAKVVILEYPVIHVYLPSQSYEFKVIKDFNTTPNPNDSLYDGHGCTNGITFREEEIEEDDIDSFEPEVLGLMKQMNYNPCLRVSEKSKAEGVGTNNSNPQVDTTEQEDAGNMELEFEQGLIDTYSDLFAEMNPGDYFNFECEFAKGLDSDDNCNLQNLDTDFIADGLDLEEGEIVE
The following text describes a protein:
Function:
Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with GFM2. Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts.
Subcellular Localization:
Mitochondrion.
Sequence:
MALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKAKGKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAKDSLRKVRTNSMNKLKKSKDTVSEDTIRLIEKQISQMADDTVAELDRHLAVKTKELLG
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MGRVIRGQRKGAGSVFRSHNKXQEGAPRLRSIDYAERHGYLKGIVKEIIHDPGRGAPLARIQFRDPYRYKKRTELMIAPEGMYTGQFIYCGKRATLNIGNVLPLGSMPEGTVICSVEEKAGDRGKLARCSGNYATVVSHNPDTKKSRIKLPSGSKKVVPSANRAMVGVVAGGGRIDKPLLKAGRAYFKYKVKRNCWPRVRGVAMNPVDHPHGGGNHQHIGTPSTVRRDTSAGRKVGLIAARRTGRLRGTKKVKDSKE
The following text describes a protein:
Function:
Member of the two-component regulatory system SaeR/SaeS. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTHLLIVDDEKDIVDICQTYFEYEGYQVTTTTCGKEALKLLSSDIDIMILDIMMPEVSGYDIVKKMKDMQLDIPFIYLTAKTQEHDTIYALTLGADDYIKKPFSPRELVLRTNNLLARMSKSNHSNKIEQLEFDGLVLKNLSKTLTINNIEIPMRIKEFELLWYLASREGEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKHDFLPYTITTVWGLGYKFERSR
The following text describes a protein:
Function:
Involved in response to cystine. Overexpression confers tolerance to excess cystine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSAAGKSNPLAISGLVVLTLIWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPTPFKYTLAIALLQTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAALFLGERLRRGQYFAILIAAFGLFLVLQPWQLDFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDLLSLTSWQMLYAALVMSVVALLVPQREIDWQPTVFWALAYSAILATALAWSLWLFVLKNLPASIASLSTLAVPVCGVLFSWWLLGENPGAVEGSGIVLIVLALALVSRKKKEAVSVKRI
The following text describes a protein:
Function:
Responsible for the transport of maltose and sucrose into the cell, with the concomitant uptake of protons (symport system).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSVDENQLENGQLLSSENEASSPFKESIPSRSSLYLIALTVSLLGVQLTWSVELGYGTPYLFSLGLRKEWTSIIWIAGPLTGILIQPIAGILSDRVNSRIGRRRPFMLCASLLGTFSLFLMGWAPDICLFIFSNEVLMKRVTIVLATISIYLLDVAVNVVMASTRSLIVDSVRSDQQHEANSWAGRMIGVGNVLGYLLGYLPLYRIFSFLNFTQLQVFCVLASISLVLTVTITTIFVSERRFPPVEHEKSVAGEIFEFFTTMRQSITALPFTLKRICFVQFFAYFGWFPFLFYITTYVGILYLRHAPKGHEEDWDMATRQGSFALLLFAIISLAANTALPLLLEDTEDDEEDESSDASNNEYNIQERNDLGNIRTGTNTPRLGNLSETTSFRSENEPSRRRLLPSSRSIMTTISSKVQIKGLTLPILWLSSHVLFGVCMLSTIFLQTSWQAQAMVAICGLSWACTLWIPYSLFSSEIGKLGLRESSGKMIGVHNVFISAPQVLSTIIATIVFIQSEGSHRDIADNSIAWVLRIGGISAFLAAYQCRHLLPINF
The following text describes a protein:
Function:
Catalyzes the reduction of geranylgeranyl diphosphate to phytyl diphosphate, providing phytol for both tocopherol and chlorophyll synthesis.
Sequence:
MAAITHPLHSLTLTFKTPNPRFTPLPKLTISATSTSNRHISGRKLTAAVIGGGPAGSSAAEALASGGIETYLFERSPSGAKPCGGAIPLCMLEEFSIPPDLIDRKVTHMKIISPSNLTVDFGKTLKPNEYISMLRREVLDSYLRSRAESKGVTLVKALVTNLDVPFQPNQPYIVNYTVNNRMKYLPVDVVVGADGANSRVAKAIGAGDYACAIAFQERIKLPDDKMEYYENLAEMYVGNDVSPDFYAWVFPKCDHVAVGTGTVSSKQYIKQYQQGVRSRVHPKIAGGKVIKVEAHPIPEHPRPVRVRGRVALVGDAAGYVTKCSGEGIYFAAKSGRMCGEAIVKASEGGHRMIDESDLKREYLKEWDSRYKMTFRFLDLLQHVFYGSNAAREALVELCGDEYVQRMTFESYLYKKLAKGNSWEDFKMVSNTIGSLIRCKLVGKQMEAFDPNVLAKVVG
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSFRGGRGGNRGRGRASFGGRDQQPSGELVPYGKFLHAAETVMVFKATSTTQYPAFNAIVYNEKKAEVGKVGEVFGPLNDYYFSVVPVEGVKPDSYNVDDQIYLYTDKLFSVDRLKNPPAPVKRGGAKGGAKGGANNRGSRGGNRGGSRGGFNNRGARGGNKGSFGGNRGGFGGNKGPRNH
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVKYDLTQTLLPYLDRHLGLPLLSHLAGSGIFSETDIAKAQYELAKNTSMVDYALQLYEQAYPNQPAPAEIEKQRENAIALNDKLGSEVDHVLEVIQDPSVASALKQDKAQNLQWLEEKYNLTSEQINALYRYGYFQFSCGNYGDASSYLYHFRVLSTDPVLTMSSHWGKLASDILVGEWEQALSELKLLREQLDSSAAHVTASYAQPSTSNGSSQNDDLTQEGLLKKRAWLLHWALFIFFNHPGGREQLVEMFLSPVYLNTIQTTCWWLLRYVVAALLLSRRTTRVYLVQQPAPATLMASVSGANVNKLSPQQAIKDIVNIIDSESYRIAGTDPIVDFLSKLFVDFDFEAAQEQLTLAEQVASKDFFLADFKDELVEACRVVISEAYCRIHSKVDIADLVKRLNLSKEDGEKWIVNLVRDTRADAKIDFKEGMVFMNPTHPPVYQTIIEKTRGFTFRTSAMGTAIDRKAHPPSLNNTHNLNGNDKRGNAGGRGGRGGQRNQGGQRDRSHAHNNEAKREGESASAEEAQQQQPAQAIAAN
The following text describes a protein:
Function:
Has a role in vesicle-mediated transport but not with protein transport from Golgi to vesicle.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MSFVDLEQGRHKIEQNGDFPALASSIAQEIHALRGNTAAIHRYLVNNLTKNLHEVLEQSRELSQKVRSDLVRLANIKDTKYGEEASSFALSKLTRDFNTVLAELQRVQQKCAQQESDSVAAAQAALNQDVGQHFIEEEERNVSLSNNSSGQRQPLTESKISNSQLEYQQRLINERQGEIENLTQGINELNEIFRDLSTIINEQGELVTNIEYNVGNTSTNTKNASRQLQIANEHSRKARKRSFCFLVILVVILGVILTALIMG
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Domain:
The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.
Sequence:
MEQKRPQLKARVDGDYGEFVLEPLARGYGVTIGNPIRRILMSSIPGTAVTSVYIEDVLHEFSTIPGVREDVIRLILNLKELVVKFHAPGPKTLTLRAQGEGEVRASAFEVPTDAEIVNPDLVIANLAEDGKLVMEVRVEEGEGYVSADKHATKDRINSIPVDAMFSPVRRVAYHVENTRVGQQTDLDRLILRVWTDGSAGPQEALDKAVEILRDELSVFGNVEPMPALESSYAAATPAAVYDPATATLPASVYDSPRQPDLGSLSINPQPFPTDQDTPRVTLEGLGLTTRVLHSLKEEGIDSVDALCALSDRDLKKVPGIGERSLDEIKQQLAQFGLALRD
The following text describes a protein:
Function:
Self-incompatibility (SI) is the inherited ability of a flowering plant to prevent self-fertilization by discriminating between self and non-self pollen during pollination. In many species, self-incompatibility is controlled by the single, multiallelic locus S.
Sequence:
MGMLKSSLAFLVLVFAFFFCYVMSSGSYDYFQFVQQWPPTNCRVRVKRPCSNPRPLQYFTIHGLWPSNYSNPKMPSNCTGSQFKKQNLYPYMQSKLKISWPDVESGNDTKFWEGEWNKHGTCSERTLNLMQYFQRSHAMWKSHNITEILKNASIVPHPTKTWKYSDIESPIKRATKRTPVLRCKRDPVQANTQLLHEVVFCYEYDALKLIDCNRTDCWNNVDIKFQ
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAWGEDEAIDPDVASMGLHVSERIGRDAVSSPPPRPSSASSSANSPRAQKHTARHVTTERARRWWPVSTFLHACEGEAMTKLTNEKVPYFNVPIYLQNKTQIGKVEEIFGPINESMSTSSPP
The following text describes a protein:
Function:
The enzyme prefers aromatic over aliphatic amines.
Subcellular Localization:
Periplasm.
Sequence:
MGSPSLYSARKTTLALAVALSFAWQAPVFAHGGEAHMVPMDKTLKEFGADVQWDDYAQLFTLIKDGAYVKVKPGAQTAIVNGQPLALQVPVVMKDNKAWVSDTFINDVFQSGLDQTFQVEKRPHPLNALTADEIKQAVEIVKASADFKPNTRFTEISLLPPDKEAVWAFALENKPVDQPRKADVIMLDGKHIIEAVVDLQNNKLLSWQPIKDAHGMVLLDDFASVQNIINNSEEFAAAVKKRGITDAKKVITTPLTVGYFDGKDGLKQDARLLKVISYLDVGDGNYWAHPIENLVAVVDLEQKKIVKIEEGPVVPVPMTARPFDGRDRVAPAVKPMQIIEPEGKNYTITGDMIHWRNWDFHLSMNSRVGPMISTVTYNDNGTKRKVMYEGSLGGMIVPYGDPDIGWYFKAYLDSGDYGMGTLTSPIARGKDAPSNAVLLNETIADYTGVPMEIPRAIAVFERYAGPEYKHQEMGQPNVSTERRELVVRWISTVGNYDYIFDWIFHENGTIGIDAGATGIEAVKGVKAKTMHDETAKDDTRYGTLIDHNIVGTTHQHIYNFRLDLDVDGENNSLVAMDPVVKPNTAGGPRTSTMQVNQYNIGNEQDAAQKFDPGTIRLLSNPNKENRMGNPVSYQIIPYAGGTHPVAKGAQFAPDEWIYHRLSFMDKQLWVTRYHPGERFPEGKYPNRSTHDTGLGQYSKDNESLDNTDAVVWMTTGTTHVARAEEWPIMPTEWVHTLLKPWNFFDETPTLGALKKDK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAHPNSQTNGASLEDCHTNFFALTDLCGIRWRKLTSEGYSPQPGGGGPWDYLNDPVLLSYWRCLSNDILCVWRRIPSASSASSPGGSSAFPPSFPSGFPNPQSSTQQGSNGLSTLSGAKELWIFWYGDTSPDLSSLVVPEILNMEGEHGSWENGLSYECRSLLFKALHNLIERCLLSRDFIRLGKWFVQPQEGVDSACTQQQQHQQPDSSNPTTTIPARNGHLSFSFSFFVHGESTVCASIDVRQHPVVRKTTHRHLAAAQATSGGVHVMLAPYGLAGALTGVSYRSATDHVTRKLMEEWRQYYPVECGLEAASDTEDMVEVIVGNVRMRYPTCYVMVCDADRMLMTPPASPPLTSNPASISRSISHSAVVSSLTSSSAVTSAHHSSTTPTTDKDSTVNLWDFVDPTTKNSCICMASTTPLNTSSSSSSSSSIPSSSSSSSSSSGKRGGGVHPFHHRPTYAAPTRAQSTVASVGQKLLPDNNNAAAALPPGNSSLPLSSPHPPASNDPSSNFIPSTPSASDHNMTSQDQNCSRATPGGAAHTPGGGPKSNQAAYSPYVALPSPRSSAGQQPASCGPATSVAPTTPNVGSGGGCSGERANGGGSTCSTADLYGIKKIVLPQKEYEEELKEGETAPGLLYDYSNMTAWLFHPVKRMKVGNNSSNGDRPTDSSDGGSSCSGKQINGNLMVSDGVHNGQSRKRKEPDSGRDEDSNSLNSANAAGGAAKPVNPSSLFTSEGLQASYQDLDKIFDNSDESNDTCPVPTPPGSNKPAGLPEDTALMGHGHHKAPRVNILASAEFSNMFPTPPSHEHPMQSPCGQMEGSVDLLGGDMNNSGHNGIKSEPGSGHSLNGCSPTYLQEDSANKDWSYVYRPPTVWKVANSSKYAPLPILPSQTMSPLFLPAPYRPSSSSNSSANHSSGIVEGQPPGFPQHQPGFPHHHPPQQQLQLQIQQQQQQHHHHHQQQPQSVNNSNNMSNHSNLPECHSLMVNIVLGDSMLNIFRDHNFDSCTVCVCSDGQNWVGTIRGQDAVFYLPESSNARSSSMRACRCNCGFSALVNRHLAHQAGLFYEDEVEIVGANATRDPGQFKRGSLYASIAAVVMEASAPLVDTLPVALMELLREQCLLVHHSSSPLYRAEQLQAATRKASLLHALDYSDGCETARNALTQPHPSHGAHGHSTNHPSTLSAGNNGPIVHYWPFLHVQGPNSSQDVIRVMRTLQPLLQDSIQKKRAASLWRAPFAVQGPLTWRQFHRMAVRGTEDRCEPQPIPSVMAGYDRDWVAIGPLAIPHWDRLLLEPYSRQRDVAYIVLAPEMDYVLSRTKIFFKELSATYEMCRFGRHVPYKGLRDGILRVGKSAAAKLANDAVDDWFSNIGDSPIASLLRLYAKVCRYHLAPTLINMPMDRTLLDPPAPPSSNRPMNAVPSPMAPPSTTPIHPGDFGSATQSGMGPPNPGGSTPLQGSSTFGVHHTSTPSSGITSSDGKPTSPKTEDGADGTSGHGASGATDGSAADDEEVDPPSIVIYIVDPFSFGSDNLDLGRLTALGLLRCYHQMLSLLSETVQLNVSLQLISADAILQLGKDLTGASRYDSLRSLALNVFSQCKKLISQPSNVKSLTGFGPAAASDTFLKAKDERNRAPYRVYIPAYVLAPTKDRTVCDLDPGVSTNGGPGSGPLSFLARPDKYSVLYVSYCLSEDQRWLIAACTDERGELVDSCTIGIDVPNRTKRKRVSVRRFGLQRLMDFILGVISTGVHPWRLVIGRVGRMGHGELKSWSALLSRKNLLRASRHLADICGQCSLVFPSQAPTLVSACLVSLEPDSHFRMMPDQVTPDERFGQQSANSHLSTPEDASCTHILVFPTSATTRSPQTTFHEENINGPDLGDDDLLSALNDDMGDGFEGMSGFDDIFMTWPETDQVNDGTDDLTSDITGGNNGGMNNMGGCGTSRSPGASHGGGGGGSPGRGGMRSNMNPESPSGMGGHHHAGGSGRQSPRAEQEEVGTLLQQPLALGYYVSTAPTGDMPSWFWSSCPHLARACPAFLKCALHLHNHAVQQNSDDILLQQQQQQVNNSSKVHPLDSQVTTDVLRYVMEGYNALSWLSLDPKSRDRRSCLPIHIQLLVQLYHALAALV
The following text describes a protein:
Function:
Small heat shock protein required for the establishment of auxin gradients and for patterning of the apical domain of the embryo. Involved in the specification of the cotyledon primordia. Also required for normal inflorescence and floral meristem function, normal developmental patterning and thermotolerance. Acts as a molecular chaperone.
Subcellular Localization:
Cytoplasmic granule.
Sequence:
MVIITEYNEQDDIPPSSSPVEEVKDKNATKAIEENKKGLQVLQSNLVCFASPVAYSADMYTAPNIGNVLDLDNYSCGQSVQEVKVANNATEAIEENKKGHLEELCGFHLHCANLLREGSCCGFLLLSPYLLQDLVFLPSMSSEAPTIGNGLDLDNYSCGQSVQEVKEANNATEVLEENKKGPLAPNIDNGLDLDNYCWGQSLQEVYVNILVPQGTKSRFIVCDIKRNHLTVGLKGQPPIVDGELYGPVKVEACFWTLEDQKSISLLLTKIDQMNWWKWVVKGEPELDTEKVEQITSLSELDPETRSSVETVMEAMGLPTLDEMQNQEMEKFIMEKYPWMDFSRAKKS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAGNTINATTASEDLQKDKEANQVRFEEDLEFVQSLANPHFVQELTLNGTLRSETMINTWIPQYFHHPDYARSSLPTLEILDLLTARAVPNDDETRACPTSGRNIHPELDLTQRSLE
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Subcellular Localization:
Nucleus.
Sequence:
TKRELDELKPWILSHVLGFSEPPVFTASMDKKKAADHLKPFLDDSTPRFVDKLRLSRHSKSSNDGSRKRKLKKVFGDNSWLSKESSGVKKQRIPHFEEVEEEPELHIKQMMDAERKKQLRFISPPTPQPKTPSSSQPEQLPTGHTIQPSQGATFMNDAIEKARKTAELQARIQAGLALKPGLISNANMVGPANLHDMGIASPKGELKDQIKPTPLILDEQGCIVDATGKEIELTHCMEPFKQQLKEKPSEDMDQKRTFKFHDKGKFEKTDQLEKLQAEISQAAQKTDIHTLTRLALIAPRKELKEGDIPEIEWWDSYIIPNGFNLREENPKREDYFGITNLVEHPAQLNAPVDNDTPVTLGVYLTKKEQKKLQRQTRREAQKELLEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVTAQMAKRQKLHEEANSKGQENLKGVHISVYGVRNLSTPKFKIEANAGQLYLIGVVLLHKGVNVVVVEGGPKTQKKLKHLMLHRIKWDEQTSNTKGDDHEEPDEEAVKKTNKCVLFWEGTAKDRSFGEMKFKQCPIENIAHEHFRKHGAEHYWDLALSESSTS
The following text describes a protein:
Function:
Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as a primary electron acceptor during glycolate oxidation is unknown.
Subcellular Localization:
Cell inner membrane. Note=Glycolate oxidoreductase activity was shown to be firmly associated with the cytoplasmic membranes. And the GlcF subunit itself could only be detected in the membrane fraction.
Sequence:
MQTQLTEEMRQNARALEADSILRACVHCGFCTATCPTYQLLGDELDGPRGRIYLIKQVLEGNEVTLKTQEHLDRCLTCRNCETTCPSGVRYHNLLDIGRDIVEQKVKRPLPERILREGLRQVVPRPAVFRALTQVGLVLRPFLPEQVRAKLPAETVKAKPRPPLRHKRRVLMLEGCAQPTLSPNTNAATARVLDRLGISVMPANEAGCCGAVDYHLNAQEKGLARARNNIDAWWPAIEAGAEAILQTASGCGAFVKEYGQMLKNDALYADKARQVSELAVDLVELLREEPLEKLAIRGDKKLAFHCPCTLQHAQKLNGEVEKVLLRLGFTLTDVPDSHLCCGSAGTYALTHPDLARQLRDNKMNALESGKPEMIVTANIGCQTHLASAGRTSVRHWIEIVEQALEKE
The following text describes a protein:
Function:
Exhibits glutathione (GSH) S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB); however this activity is as low as 1% of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity.
Sequence:
MSKPAITLWSDAHFFSPYVLSAWVALQEKGLSFHIKTIDLDSGEHLQPTWQGYGQTRRVPLLQIDDFELSESSAIAEYLEDRFAPPTWERIYPLDLENRARARQIQAWLRSDLMPIREERPTDVVFAGAKKAPLTAEGKASAEKLFAMAEHLLVLGQPNLFGEWCIADTDLALMINRLVLHGDEVPERLVDYATFQWQRASVQRFIALSAKQSG
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MSDDMLNTRRLRDPAKSDLLHLLDGVEQFSDEVFPATQALFESLAQGQAPHTLFITCADSRVSPEMITQTHPGELFVCRNIGNIVPAYGEMLGGVSAVVEYAVLALNVRQIVVCGHSDCGAMRGLAGTAPMTAEDMPTVNAWLRNAETARSVVQARKVDSDHVVQALVEENIRLQLMHLRTHPSVAGRLAQKRLDVQGWVYDIGHGRISVFNEDDDRFESLGEARTRIQREQGS
The following text describes a protein:
Function:
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MASHSGPSTSVLFLFCCLGGWLASHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
The following text describes a protein:
Function:
Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity.
Subcellular Localization:
Secreted.
Sequence:
MLPVRAAAKTKGIRAEDVKGLLPLMILMVIIFLLLLFWENELHEEREVPTLEHLHVDYPQSDIPVRYCNRMVLQRVIRGPDNTCKKEHVFIHERPREINRVCTSPKKRVCQNHSSILCFQSVTKFKMTACQLIEGTRYPACRYHISPIMGFAVVTCDHMGPVTLQRYVE
The following text describes a protein:
Function:
Multidrug efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
METDMTKGKPMGIIVKFFIPMFIGNLFQQIYNVVDSIVIGRFVGNEAFAAVGSCFLIMSFMTSILIGLAMGASAFFSQLYGAKQYDEMKKAISTSFFFILSISILLSLITNVFLYEIIELFQMPKDTVTYSAEYLRYILTGLIFTGLYNICAYLLRSIGDSKSPLYFLIVSCILNTILDLIFVLVFNMGVSGVGLATFIAQGLSALWCAFYTVKHMKFLDFKRKDIVFSRKLFRTILSYSVLTAVQQSLSSFGMLMIQGLINTFGTTVMAAFAACSKIDEFANRPLQDLSNAFSTYVAQNKGAGNIERIRQGFYAILKVIALISFIISIVVFIFAPNLISIFVKKESIDIIQVGVGYLRIVCIFYILLGCIVMFYGFFRGMGEVNISIILTVVSQGIRVALAYGLARTSMGFTGICWSIVIGWLLSNALGRFMYKKVMANPI
The following text describes a protein:
Function:
Initiates the restart of stalled replication forks, which reloads the replicative helicase on sites other than the origin of replication. Recognizes and binds to abandoned replication forks and remodels them to uncover a helicase loading site. Promotes assembly of the primosome at these replication forks.
Sequence:
MNPVSELVADVAVLTDSLPSQHQGIFSYRVPDHLQAAIAIGQLVWVPLRQQQVQGVVLAMQRRTVSGLRDLIDLVDPDLSIPQLTIQLAHWVAENCYTTLAAVLDLCLPPGMIRQAVTTWRATAAGLTCELGALPERERAILFYLRRHGELSEADLRAALRGSDANLRAAYRSLAERGLITRRLRIDPPRVRPQQEQFVRLTLPDLDQAIAELRRAPRQAAALRWLAERTTSDPPTVNELRRATGIDSTGIRALERRGFVQLVGREIYRDPLATVHPATDTPPPLTSAQRVAYETIVTALEAGTGGRFLLYGITGSGKTEVYLRLIARALRLGRQALVLAPEIALTTQLVRRFVARFGHQLAVLHSGLSDGERYDEWRRLRRGEARVAIGARSALFAPLPDLGLVIVDEEHEPGYKSDAAPRYHARDAALHLADLAGVTVVLGSATPSVETYYAARNGQIQLLELPERIGAQIGVDGLVHSRPLPLPPVRIVDMRHELQQGNTSIFSIKLQHALAQTLARGQQAILFLNRRGAASFVFCRDCGYVARCERCAAPLTVHYDTATTAEAGESVRVLICHSCGQRTATPVVCPQCLSHRIRASGIGTQRVAEVVRELFPDARVARWDRDSISGKNAHDALLEAMVRHEIDVLVGTQMIAKGLDLPLVGLVGVVLADTGLHLPDFRSGERAFQLLTQVAGRAGRRSEGAQVIIQTYQPDHYALQAACEHDYRAFFREEIAFRRALAYPPFGRLVRFVTTAATESICRRQAEQLAVTLQTYITGRDLVGWRLIGPAPAFFRRQRDRWRWHVLLRVPPATDIREIRLALDAVGPLYGWVIDIDPVHVL