lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MARIPRCDFLGLPGICYLLSFLLAGLLLPRASAFNLDVMGAIRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDRGANVQKESKENQWLGVSVRSQGAGGKVVTCAHRYESRQRVDQVLETRDVIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAATFSPDSHYLIFGAPGTYNWKGLLFVTNIDSSDPDQLVYKTLDPADRLTGPAGDLTLNSYLGFSIDSGKGLMRSEELSFVAGAPRANHKGAVVILRKDSASRLIPEVVLSGERLTSGFGYSLAVTDLNSDGWADLIVGAPYFFERQEELGGAVYVYMNQGGHWADISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVTKPSQVLEGEAVGIKSFGYSLSGGLDVDGNHYPDLLVGSLADTAALFRARPVLHVSQEIFIDPRAIDLEQPNCADGRLVCVHVKVCFSYVAVPSSYSPIVVLDYVLDGDTDRRLRGQAPRVTFPGRGPDDLKHQSSGTVSLKHQHDRVCGDTVFQLQENVKDKLRAIVVTLSYGLQTPRLRRQAPDQGLPLVAPILNAHQPSTQRTEIHFLKQGCGDDKICQSNLQLAQAQFCSRISDTEFQALPMDLDGTALFALSGQPFIGLELTVTNLPSDPARPQADGDDAHEAQLLATLPASLRYSGVRTLDSVEKPLCLSNENASHVECELGNPMKRGTQVTFYLILSTSGITIETTELKVELLLATISEQDLHPVSVRAHVFIELPLSISGVATPQQLFFSGKVKGESAMRSERDVGSKVKYEVTVSNQGQSLNTLGSAFLNIMWPHEIANGKWLLYPMRVELEGGQGPEKKGICSPRPNILHLDVDSRDRRRRELGQPEPQEPPEKVEPSTSWWPVSSAEKRNVTLDCAQGTAKCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYMSVKSLEVIVRANITVKSSIKNLLLRDASTVIPVMVYLDPVAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKLGFFKRAKHPEATVPQYHAVKILREDRQQFKEEKTGTIQRSNWGNSQWEGSDAHPILAADWHPELGPDGHPVSVTA
The following text describes a protein:
Function:
Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity).
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Domain:
GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Sequence:
MWTVQNRESLGLLSFPVMVAMVCCAHSSNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNRLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTGVSDPKATMYSYDSASIQYRKPLSSREGFGRGLDRHGVPGKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGDFKNMILFIYTLVLFILHGYGFLYIFHAEYTSEFKYPEIMWFLLFITSLQYLDIPFSFFLTKSNPVAVFVQVSGRLLVLWVASHMVSWKYAAFSLVAVYLLSELCRGPYYLSNCLGTPNRSLTWLRYNAFKVLYPVGFTCEALVFINVFFVSGKIPIDIKDRYFQYSLLFTVFFLTIVTFLYRSMSRKAAQKNKTLAKME
The following text describes a protein:
Function:
Organizes linear element components on chromosomes and is thus required for meiotic DNA recombination.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to DNA double-strand break (DSB) hotspots.
Sequence:
MDIFSEFLNCLSSDGTLNESSIYKTYQILESLNPKDVDTKENYIKLSNTFSTLGSGVGFQDNLLIEMFKILTVLFFKTRSTDLGDLLIESFTSLEIEKLMRVKKTIGSIVLTKGIQELQEIELPKVGFNCMTYDESIFQGISLERLILQLMSIFIAKCEENKLWLVNNRKDLDLRVIGQRLLHRDFACRFLSGLFISRFSVSGDTDESKHQNGIRLQLFIDFSKFETRLTMQILKADRIFSTCVANTVHAYEGLFSSGSNIDSTIATLVLEPRDLIVYRKGFALLQIPWTSVTTIDKIKKVKSLKIITEVSSLDEFVFQCKDGDKFDELFSTSEEIMNKLLPAIIVSPKLTLRNRSIIQIKEGESKLPNTSKQASQNLPHLDDELAYQRFEDQVIDKSVCDDECTNTENTPSSNIPADVKDSLSADDYAYDTKRKTQIEDLEEDQNKSKIASKDGTNLKEINSVPEFSDENVINQTGPAKKTPVQRRKDGKFAKSTKRKKQKSLKPDTENQESSVKNKKAKSNVNLQYSPKTPICKINDETLKPPTIANIAGHKQMNHLTSENIETPVPVPNGNWYNGVKHETATDIFTTCHDGNNSLKSSVWKELLKEKHWKQESKPQLTGNSRQIDLSTFVKQANTPNITSLLDGTCSSPPNNECFNDKEPDSSSSTLISDRQELEYRNPNAETVKLEEIPYNKFFKTVEKNEAYNPSSKSATIDGLQRYTSMIGNQIYEGILQNEKELRSKLEAYHINCNKVIKEFSKRQTARYKIIEKELAQIEVNLVSQIDSLMFK
The following text describes a protein:
Function:
Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion.
Sequence:
MNPTMARYGADARLSAEFEQSVESGKSFNYSNSITHEPEAVADHQMAAYLSKIQRGGFVQPFGCMIAVEEPTFSIVSFSENCFSMLSLNLDNPEKKTLLGVDARTLFTSTSRDSLERAVASGEIKLFNPILVHCVTTRKPFYAILHRIDVAVVIDLEPANDSDPAVFFAGAVQSQKLVVRAISKLNSLPGGDIGAMCDTLVEEVQKLTGYDRVMVYKFHDDEHGEVISEVKRTDLESYLGMHYPAADIPQAARFLFKQNRVRIIVDSQAKSVPVIRNQELKQPICLVKSTLRAPHGCHAVYMDNMNSVASLVMAILVHDNESTKLWGLVACHHATQRYIPFPLRYACEFLMQSMGLQLYMELQLAEQIAEKKILRMQTTLCDMLLREDPFRLITHSPSIMDLVKCDGAALYYDNEVWLTGVTPNESQVTDIVKWLCSEHKDSTGFITESLLHAGYPGASLFGDTVCGMAAARITLNDFVFWFRSQTERQIKWAGAKHHPEDKDLNIMHPRSSFKAFLEIVKFRSLPWEDSEINVIHSLQLIMRTSAQNVADNSGGGQRVMNYSQRSESDAQRVAEISSAACELARLVETASVPIFGVDVCGLINGWNGKIAELTGVKASEAIGKSLIDEFVHETSHGVVEDLLCRALQGKEEKNIELKLRKVGMQQQNKPILYIMANTCTSRDYMNNIVGVSFVGQDVTDKKTIMDRFIRMEGDYNSIIRTLNPLIPPLFASNENACCSEWNAAMEELTGRMKHEVFGKVLPGEVFGGLCSLKDEDTLTKFMITLYTAINGHDSSDLPFGLFGKDGNLVEGHLTTNTRVGEDGKVVGCFCFLSVRMPLEDGKNEQESVFKRDDLAYIKREIKNPLNGLLFTRELLQKSAISDNQKQYLETSVACERQIASIVENLDIKSIEEGNVELNSDQFFMENLLDAIVSQVMIVLDEKNIPLVHEIPNQVKMLDLIGDQIRLQIILSDFLISAANHAPSPDGWVEIKVSPGLRMKQDGHEYIHLQFRMTHPGTGLPADIIRDMYEEGKNQGTQEGLALNLSRKLLNVMKGHVHYVRDDNKCCFLIDIELKIRK
The following text describes a protein:
Function:
Probable serine protease inhibitor.
Sequence:
SFRHCLDRGACAHVGCVRVSSPVAARSPREHDGQGPRNFATHIGCGKRTETRIATASDGLPCLPIGSNGQRATWPNTRLTKQFTASHGDAARNLVFSPLSIYSALSLVAAGAQGKTLRELLDLLGTGSRDGLDANVRAMVEQAIPAPAASHQEGGPRVSYARDGLQGLMDAMASSPSFLQDNLPLNKVEVGEFWVPRFKMSYTRSLSEDLHDLGVQAVFSGAAELPDLLEEDDESHEPLFLGNLLHKAVIEVNEEGTEAAAVTASDMFTSCGLGWQDPPPVDFVADHPFAFFVVEEVSGAILFAGQVLDPTRS
The following text describes a protein:
Function:
May have porin activity and function in peptidoglycan binding.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKSIILLAMVLGAFTAKAQSVVEGTKFADNWSVEVNAGAITPLTHSAFFKNARPAFGVGLSKQLTPVFGLGFQGMGYINTTPSKTAFDASDVSLLGKVNLMNLFAGYNGTPRLFEVEAVAGAGWLHYYVNGDGDQNSWSTRFGLNLNFNLGESKAWTLGLKPAIVYDMQGDFNQAKSRFNANNAAFELTAGLTYHFKSSTGNRYFTEVRVYNQGEIDDLNASINALRGQVNNKDGELNSANQKISGLQQELEECRTKVVPVETVVKTARVPESIITFRQGKSSVDASQLPNVERVASYLKKYADAKVVIKGYASPEGSAEVNARIAAARAEAVKTILVNKYKINASRITAEGQGVGDMFTEPDWNRVSICTIED
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane.
Sequence:
MSDPSTSAVGANQQQAVSGPVRPDMVASAITFLSDPKVQSSTMSQRVSFLESKGLRPNEIDEAIRQANQSQATGSTGYASYAAGPPAPYYGGAPYGAYPAGASQHQGRDWRDWFIMAVVSGTIGYGVISLAKKYLMPHLQPPNANVLEADLDSLTAKYDEVASQLQALDAQTIAVKQGLEEQKAEVEKSIKEVEHCVKSVRENEKRRDGELDRIKDDVEGIRKELASLFEKSKQAQTNSLSELQSELKSLKSLLVSRGTVGGQGGAMHGAGASIPPRPYGVGYGAGSYGSPTIGTPTGDASPPHLPKPTIPAWQLAGAGSTNSGAATPTSTVTKEAEGTSRATESTPADPAEEMSKSEGKSKEASD
The following text describes a protein:
Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAQSQGWVKRYIKAFCKGFFVAVPVAVTFLDRVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVHRGDIVSLVSPKNPEQKIIKRVIALEGDIVRTIGHKNRYVKVPRGHIWVEGDHHGHSFDSNSFGPVSLGLLHAHATHILWPPGRWQKLESVLPPERLPVQREEE
The following text describes a protein:
Function:
Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. The interaction with host E3 ubiquitin ligase SMURF2 facilitates virus budding. The interaction with the nucleocapsid and the plasma membrane may also facilitate virus budding. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur (By similarity). May play a role in genome replication (By similarity).
Miscellaneous:
MISCELLANEOUS: Most abundant protein in the virion.
Subcellular Localization:
Virion membrane; Peripheral membrane protein. Host late endosome membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein. Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. VP40 contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase and the three WW domains of SMURF2 E3 ubiquitin ligase.
Sequence:
MASSSNYNTYMQYLNPPPYADHGANQLIPADQLSNQQGITPNYVGDLNLDDQFKGNVCHAFTLEAIIDISAYNERTVKGVPAWLPLGIMSNFEYPLAHTVAALLTGSYTITQFTHNGQKFVRVNRLGTGIPAHPLRMLREGNQAFIQNMVIPRNFSTNQFTYNLTNLVLSVQKLPDDAWRPSKDKLIGNTMHPAVSIHPNLPPIVLPTVKKQAYRQHKNPNNGPLLAISGILHQLRVEKVPEKTSLFRISLPADMFSVKEGMMKKRGENSPVVYFQAPENFPLNGFNNRQVVLAYANPTLSAV
The following text describes a protein:
Function:
Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
TTLHYERPTLVPVFQKKFEEDFSSGYQIWEPLRWILMQDFTPKGNAGTFQRGYSLYYNEYVNVNKQSIAGLSMVILPYTLLNYCHSDKELKHERLCKYHRRGRTLHS
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGRLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSLDTDPSMLGSSKNTRLSDTPPLLQQNCSC
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MIDHRLCFTMTYSNLHCRLGTLVNLTSILFILLFVTVSFPDAIIRSPSVDVHAEVSKLNRFRKRLNGNDEVSLNLNISVDLSSVFNWKTKQLFVFVTAEYKTLQNSFNQVILWDRTIHDRDSAKFEIYAKNKYLLIDQGCHLLGKEIQLVVNWYVMHKTGWMSRHNKSMSYFELPQVYI
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Sequence:
MTMYVIKRSGRKEKLDINKIRIAIKFACEGLNVDPLELEADAQIQFRDGITTKEIQQLLIKTAAEKVSAERPDWTYTAARLLLYDLYKDVAHLRGYSLRDDLGKYKPYNRKNFYSFVKEYVEKGIYGEYLLENYSEEDFNKLANYIKPERDLYFTYTGIKILYDRYLVRDEEGRVIELPQEMYMLIAMTLAVPEKPEERLKWAKKFYDVLSEHKVTVATPTLMNARRPFTQLSSCFVLTVDDDLFDIFDNVKKAGMISKFAGGLGVYLGKIRATGAPIRKFKGASSGVIPVVKLINDTMTYVDQLGMRKGSASITLDIWHKDILDFLEVKTNVGDERKKAHDIHPAVSIPDLFMKRLKNREDWTLIDPYWARQYITRKIYDGKYKEVKPLPGSHYYVGIKEDGTQDILEPKGLEDFYGEEFEKWYLELEENLPSYAKKKVNSFELWKRLLTVAFETGEPYIFFRDEANRKNPNKHTGMVYSSNLCHEIVQTMSPSKHEKPVLDPETGEITYKKEAGDLPVCNLGSVNLGKVHTEEEIKEVLPLLVRMLDNVIEMNFYAIPEAEYTNKRYRAIGIGVSNYHYCLVKNGIKWESEEHLKFADKLFELIAFYALKGSLELAKERGRYKLFDGSNWSKGILFGRSVEEIEENSRQNGNNLPWRELAEEIKKYGIRNAYLLALMPTGSTSLILGATPSIDPIFARFYKEENMSGILPQVPPEVDRFYWHYKTAYTIDHEWTIRAAAVRQKWIDQAQSLNLFVDPQNIDGPRLSRLYELAWELGLKTIYYLRSRSAMDIEECEACSV
The following text describes a protein:
Function:
Plays a role in spermiogenesis and fertilization.
Subcellular Localization:
Nucleus membrane. Note=Located throughout the subacrosomal area.
Sequence:
MENFSLLSISGPPISSSALSAFPDIMFSRATSLPDIAKTAVPTEASSPAQALPPQYQSITVRQGIQNTALSPDCSLGDTQHGEKLRRNCTIYRPWFSPYSYFVCADKESHPEAYDFPEVQQDEGKWDNCLSEDMAESICSSSSSAENTCPREATKKSRHGLDSITSQDILMASRWHPAQQNGYKCAACCRMYPTLDFLKSHIKRGFREGFSCKVYYRKLKALWSKEPKAWLGDRLSSGSCQAFNSPAEHLR
The following text describes a protein:
Function:
Catalytic subunit of the adenylylsulfate reductase which catalyzes reversibly the reduction of adenosine 5'-phosphosulfate (APS) to sulfite and AMP during dissimilatory sulfate reduction.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three sections from the N- to the C-terminus: FAD-binding domain, capping domain and helical domain. The FAD-binding domain and the capping domain slightly overlap and form a channel that may transport the substrate.
Sequence:
MPKIPSKETPRGVAIAEPIIVEHSVDLLMVGGGMGNCGAAFEAVRWADKYAPEAKILLVDKASLERSGAVAQGLSAINTYLGDNNADDYVRMVRTDLMGLVREDLIYDLGRHVDDSVHLFEEWGLPVWIKDEHGHNLDGAQAKAAGKSLRNGDKPVRSGRWQIMINGESYKVIVAEAAKNALGQDRIIERIFIVKLLLDKNTPNRIAGAVGFNLRANEVHIFKANAMVVACGGAVNVYRPRSVGEGMGRAWYPVWNAGSTYTMCAQVGAEMTMMENRFVPARFKDGYGPVGAWFLLFKAKATNCKGEDYCATNRAMLKPYEERGYAKGHVIPTCLRNHMMLREMREGRGPIYMDTKTALQTSFATMSPAQQKHLEAEAWEDFLDMCVGQANLWAATNCAPEERGSEIMPTEPYLLGSHSGCCGIWASGPDEAWVPEDYKVRAANGKVYNRMTTVEGLWTCADGVGASGHKFSSGSHAEGRIVGKQMVRWYLDHKDFKPEFVETAEELKTLIYRPYYNYEKGKGASTCPVVNPEYISPKNFMMRLIKCTDEYGGGVGTYYNTSKALLDTGFWLMEMLEEDSLKLAARDLHELLRCWENYHRLWTVRLHMQHIAFREESRYPGFYYRADFLGLDDSKWKCFVNSKYDPAKKETKIFKKPYYQIIPTDA
The following text describes a protein:
Function:
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.
Sequence:
MESLQPEQILSSGALVLVLDVPVGSEFGIDYKSWHTAARFKGVKLVPAGVHYVFCSARQSRSEHGQHLGPRIGYFVHTAPGDVLIFKWDPTEEHIVNTHADADQQQRVRDDYVGLDPYLAAYPLEETLSTWISLTSKITRATLARLQPTCEYISSATELEGAQVLTSRRSDRPDQAAAGTEEQPATPAQSIFETHKDAWRDMRPASTVQIPFVQVPRRLFPPGATPAQVTQHSLDRSYTLQQVLTSHFAHDPNELLAELQYAFVCFLVGQVYEAFETWKQLVALLCNSGQAIADHPQLYIDFMGVLHYQLKETPSDFFFDIVASNNFLVHALEAFFAHAEHTDNVAQHVRTHAHQFKSWNFDDEDDGDGPVVVET
The following text describes a protein:
Function:
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor (By similarity).
Miscellaneous:
MISCELLANEOUS: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
Subcellular Localization:
Secreted.
Sequence:
NILDGYVRXEGAWLLSRIYLDEVEGRDVVYYRT
The following text describes a protein:
Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Sequence:
MRGTSCLWALLPLLLGAAGTLESAGCGQPRVASRIVGGRDARAGEWPWQASIQHRGTHVCGGSLVAPQWVLTAAHCFPRRALPCEYRVRLGALRLGPAPPGALLAPVRRVLLPPDYSEDRARGDLALLQLRHAVPLSARVQPVCLPEPGSHPPPGSPCWVTGWGSLQPGVPLPEWQPLQGVRVPLLDARTCDRLYHVGTTVPRAELIVLPGNLCAGYAEGHKDTCQGDSGGPLTCLKSGRWVLVGVVSWGQGCALPNRPGVYTNVATYSPWIQAHLSL
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MEGKIRALLPFNTWQTAIPFHTWRTAIKMMYRGEASNPSPLLGFTDSPQFCSPIRRSSAHLKGEVISEENSLEFGTDKIEMHVGAVQANDRALVVDDLIATSVQLSNLSRRKNLFDVVQILPEWGIGYKVANTTWCDVSCQITKINLYKQIWGAHISRAICWFRIPFAGDGFGSTPEMSKRNLFWVVSQMQAIVERYPCWGDTVEVNTWVSANGKNGMRRDWHIRDSMTGHTTLKATSKWVMMNKLTRKLARIPDEVQTDIEPYFVGRSAIVDEDNSKLPKLPEGQSTCAAKYVRTGLTINVRYNLVFDSFDVVGVECKKSHASWIVLDKI
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MCQVCGAAEADLHFGGISCRACAAFFRRFFLSKKQSKKCTCKTRILDSHPCRSCRILKCFEAGMTSKKIQSGRDKTSTKAISCISTESTSNSLSARIIPRSSLNIHGAVHLWQEFENTRACKKGTKRNALIVSTSSAGDMDSTWKMVINLFSSLGELEIKDKTALLRNFMPKFIQIDSVPYFAANIDVFKNIGRDEYESSIIDFYDGVLPETNTISKKDTIRIFEPYWNFYTNKVILPIALMKLEGPEFMALVWLLFFDNGYTNLSDKCREACRNIKKVILRELRSYQIDRNFDRNRFFEILEALQLVERGEKKFMEEMVICELLNIKIDPGFMEIIRESKL
The following text describes a protein:
Function:
Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II.
Subcellular Localization:
Nucleus.
Sequence:
MMLRSQAKNVDLTSQADSRHQQKRKQAEQLDALKNPSEPAAKKQHSKGLTELRAHISGFKIDSAKRDPLGKSRTSRRDVENLPPQKSRYVDPCPHYDYDLEEAGNPDSISDYAQGIFDYYRHREVHFRVRKYLHKHPEVDVKTRAILIDWMVEIQETFELNHETLYNAVKLTDMYLCKTKNVDKNTIQKLACVAIFIAAKYDERSPPLVDDLIYLSGDRFSRDELLAMERELFATVGYDLGSPLSYRYLRRFGRVCRVDMKTLTMGRFILETSLMVYEYAMVSQSRLAAAAFVLAMRMLDKNNEYEWNPVLEKYSGFTGEEVMPLVEHMNHILHFSKDKWAQLTSVRQKYSHEVFFHVASIPMLPDTLKVVDSHTYAPVPMLSYP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLVLPAPGPRPPAFPSAEAMQAPPPRTGGSPEPGPSCSTGCPQTSPSSSRPNHYLLIDTQGVPYTVLVDEESQRESGPDGASAQKKCYSCPVCSRVFEYMSYLQRHSITHSEVKPFECDTCGKAFKRASHLARHHSIHRAGGGRPHGCPLCPRRFREAGELAQHSRVHSGERPYQCPHCPRRFMEQNTLQKHTRWKHP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MTLLPTKLTDCDQYCMFDWDMMWAPQVQFHPQKPLVIPVGPGVGGLQVTGTMEDVLGEKCSHCDARFHSSVARMTHEFAEHANATSERQKMGQDGQTNGKKMAETLSPPPQPPPAEQGLVPSSMEQLPSPSHKEYKCKLCPQVFISKSDAQRHARHSHTEEKPYKCPSCGKSFANSSYLAQHSRIHTGIKPYQCTYCERTFKQLSHLQQHVRLHTGDRPYKCTHPGCGKAFTQLSNLQSHSKRHNSDKPYQCNKCFRAYGDAAGLQIHLSQHAHRTHPKSFICNICHKAYTSESYLVKHMLKHSSQCPHTGPADDGTPSPTTTQQDSTKQPSPPLLSPPPLLSSPPPSLLTSDPGLTGAQNSITMSKSSADGAPVVTQYFSLDSQFNDHTAALVGSLRQHMETNARQLQRQLLPDRGRPKEVSAANSLSSAFTAVNSTSSLSKPML
The following text describes a protein:
Function:
Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo. May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MGPSRTGAVLAALGVLSVCAVSGSGPEAERETGGDAGWAEPWDGAVFRPPSALGAVGVARKPGTPRLGREEAVDLPVLLWWSPGLFPHFPGDSERIDCARGACLASRDRGMWGDPRTRALLFYGTDFRASEAPLPRMGHQSWALLHEESPLNNFLLSHGPGIRLFNLTATFSRHSDYPLPLQWLPGTVYLRSAAPPLQERAEWRRRGYAPLLYLQSHCDVPADRDRYVRELMRYIRVDSYGKCLQNRELPTPRLQDTATATTEDPELLAFLSRYKFHLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSIILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKEPGGITNQFLLDSLKHREWGVNDPLLPNYLNGFECFVCDHELARLEAEKAHAASPGDIPLPEPHIAQLSHLDCPMPTPGFGSVEEIPENDSWKEMWLQDYWQGLDQGEALTAMIRNNETQQRKFWDYLHEIFMKRNQNL