lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability.
Sequence:
MALSFFSGGGSASHAKYFDIRLDEDYIVFRGGEQEAASAHLSGKLVLCVSEPISIKHIRLHLTGISRVCWHLPSSSAGGGRKNWRERVFYEKTWKFRDAGKSKTEILPAGNYEYPFDVILEGSMPESVEGLSDTYVTYRFKAEIGRKYAKDIVVRRPLRIIRTLESSALELSHAMSVENIWPNKIEYSISTPTKAVIFGTSIRVDFKLIPLLKGLGIGQIISQLIETHDLTLNPEDPDAIRNTYKTTRTIINDEHTIDEENSLEIIDEAAEGFQFSRTLDLPKTLTRCLQDTDTRGIKVRHKLKFRVQLLNPDGHISELRATLPVSIFISPNLAIDDNNNLVDSSPQTTQRALDDLAQQAPPLYGEHQFDQLYSEVDPSGYRTPGPGSGPGTPFGTLSRNLSAENLASMNAITHTDISASALHHRLVNLDLRGHGRVSASEHDHLGVPSDNGPPSGSNTHGSNTHAPGSPELSRRASDEDVHDNIPSGMATPFIPHSAELETLSRVPSYSTAVRSSVRPHDSDLPDYQAVVAETVHMSAPQSPQQAHIRGSGTGRGSDSYFSAPMDFFHRPAFLHSRSHSHSDDERRIRLTQARGRA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
Sequence:
MQTYSHGYNVPPLPIRRKPTPLDAAPTTPHATHRQPQAYAPFTPQQQPYLDPPPPYAGPTQAQGQSPGSAFELIDLIDDYLDDFDDAPAHSLATAGSGSHLRQPSAVPQPITFHKEPTTAFTTREVLVKDEKPPLLPPKVPERQQRPGTPNGQGTQGQTFHAYWPAANNLPSSLDLGEQALDRPVSRGTRGSETPRHEHPSVLQPGGGRGLSSPFHGRPRTAQDAHYGDGHYQHYQQQHQGHGHAYGLPYDNGGRLWPTMMDIPPERQPHGNYQEPHTQQHSRNHNNLKVQTSMPTLRPGPPLPSSSHLSPYPTPSPSAYTFEPPSAAPRSPSGLVPPFPQRAATTGHGGRFGPPPGLGNDKYRQQPHTPLTPHSPYSPSYNMSASSPSRCGSALPSPGPPEDPGTFGSGQGSAWNGASGAGPTFDGLGFPGPPPGPPPPRAATTTAAIPFPPPPPPPPRLPGPPPQTLGFPGHHPPPQLAQAFPPPPPPPPPQCWPERPHPHLQHAKTFAIAKPPHSQQQPQLHHSQSLPQLQLQQSESSRKEETKGFWSNALSETAYLASGLISHPFESTKHYTILRHSPAVIWHHGPKTTVTISIFSSPKYPLPALPSLPPAAGVSSDVAGNGNGWSLWIQQRGFSGDSGMKIKNWLGGREDWVCVTPASKVLAEELETGSAGKTGGQGLLGLGGATEERGWKRDIKRTEKKLKKEFGDKKGHVARLTAVVRVPEGCEDGYFRVHLCVNPDGSEKDHEKRKKSEKDPQSLLEEQRKKMKVLCSSPIFRLASTSTDPSSIRGASLSTMPLEMGISLTSFIASEMVASKIAPIKDPITKIIDPYRAHPIVEELGIIATEEVKAAREEAEAEEQERLRELFGAMCVVGAGGAAAGMATRRGPEGRQQGSGMPGVVGPDEGPLAPLPIRFGGKVVPGTGRSTAEMGIPTANLKDLPEEIKHYFKGVYFGYTRIIPGKGGPMGPGGPMEEVWYEAIISSGPVPYARKTAVIVEQQTTVHLITDFGAGVTFFGSKVEVLVMGFLHPVLDYRETGPQYRLDTAHQDVVLALASLNRPRWTAQSTLQRMEAAETNADGERGLTGGFRRTKVVEKGQEVKEKIIEAKDAVAKQIDRIPVHKVGIRRDDGKARDRYYGTGGYWIPRC
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MRIICIFKIVCAIISIILNCILTLLILKKSPPKLGAYKYLMIYIALFEGYYSIWDLITEPIVHSYKAAFVVLRDFNGSVFDREISFILICVYCGLFGFSLAIFGVHFIYRYGAVNKTFMDKFLPGNQVYILFLIPMWYFTWWGVLCYIYFHFSPRTDAYMEETIESHFALSINDSSYICVYYQPTGEDGKPHPDPKIFFAIGCMWYMVISSMFCVFYFGIRCYSQISNTISQTSTTSTSLKNLQSQLFNALVVQTIIPLVLMYIPIGILFFFPMVIWELPFTTSFVGYTIALYPAIDPLPNMIIIRFYRQAIIDFFLKILGRKKNANQFNSINLVEVAPIS
The following text describes a protein:
Function:
Transcription factor that globally supports gene expression in response to hydrogen peroxide.
Subcellular Localization:
Nucleus.
Sequence:
MVFFPEAMPLVTLSERMVPQVNTSPFAPAQSSSPLPSNSCREYSLPSHPSTHNSSVAYVDSQDNKPPLVSTLHFSLAPSLSPSSAQSHNTALITEPLTSFIGGTSQYPSASFSTSQHPSQVYNDGSTLNSNNTTQQLNNNNGFQPPPQNPGISKSRIAQYHQPSQTYDDTVDSSFYDWYKAGAQHNLAPPQSSHTEASQGYMYSTNTAHDATDIPSSFNFYNTQASTAPNPQEINYQWSHEYRPHTQYQNNLLRAQPNVNCENFPTTVPNYPFQQPSYNPNALVPSYTTLVSQLPPSPCLTVSSGPLSTASSIPSNCSCPSVKSSGPSYHAEQEVNVNSYNGGIPSTSYNDTPQQSVTGSYNSGETMSTYLNQTNTSGRSPNSMEATEQIGTIGTDGSMKRRKRRQPSNRKTSVPRSPGGKSFVCPECSKKFKRSEHLRRHIRSLHTSEKPFVCICGKRFSRRDNLRQHERLHVNASPRLACFFQPSGYYSSGAPGAPVQPQKPIEDLNKIPINQGMDSSQIENTNLMLSSQRPLSQQIVPEIAAYPNSIRPELLSKLPVQTPNQKMPLMNPMHQYQPYPSS
The following text describes a protein:
Function:
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAKTCDAL
The following text describes a protein:
Function:
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way (By similarity). Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (By similarity). In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria.
Miscellaneous:
MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAAAGPAAGPTGPEPMPSYAQLVQRGWGSALAAARGCTDCGWGLARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESAWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYWFLYIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEKPLRNGLVKDKRF
The following text describes a protein:
Function:
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Sequence:
MPKRKIQRERPKEKFSYDPRKVLKMLDEHARRILEDIKAGKNPHFDIPMRGLSNVYFDEKSRLIKMGDKLSRRYFLNVAHARKFMQTLLIMAYVKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERMFGVLREEMHITADRRGYIYGDIVIRDGEDEFNASRLGSGGWAVPGTVEHIQFPEINVDYALVVETAAMADRLIEEKFPKRENALIIATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSDKLATPESKFVGMTMDDIKKYGLENVTEKLKGIPPNKKGGPTGDYKRILEEMNYPWFQNKEWQRQLQLALKWGVRIEQQALANKSLEFVAKEYLPEKINNGDLLP
The following text describes a protein:
Function:
Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
Sequence:
MCVVCGFLYHEADGIPEEGIAPGTRWEDVPDSWTCPDCGVTKDDFEMVEID
The following text describes a protein:
Function:
It is a regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). It may regulate its own expression at the level of RNA processing.
Sequence:
MPCNCFKSNVHVQEYKDLLVFGYASTIFPNDYQSEHIAEERHTVPCLGDPENRVDRYDCRLLLPSIDVAIKRNGSPSEQCPTEAMEEDMCEEERYLDMYKDIQREQEKEEEEKRRNDQRNAIGFDYGTGKVKARESDSEDEPFEPPEGIKFPVGLELPSNMKLHHIIEKTASFIVANGTQMEIVIKAKQRNNAEQFGFLEFDHRLNPFYKYLQKLIREKKYIPDLNKRPKKLTKTSRASTSKPAISSSLAAIAAAHGSDSEDSDSDYELHPSLLSGGAKRPVTPEKPGAIGPRKKPVEPEKPPDFTLKPVGDISQRNDVYAALFKNLAHVTRQAAGVEEVKMNVEEAKKEKENDHLDDPEYREWYENFYGRPCPWIGPRPMIPATPDLEPILNSYAEHVAQRGLEAEASLAAREDLQLHFMEPKSPYYSYYHHKVRMHQWRMYQPIEQNLSPLVLNSPAPPSAVSSPGPSSLMSLNLSTPEPPLNRRQRRRLLDSSRLDESITEPGVIDPITMLQIPKSVSTPANLDILKTPISFSLRNDEPRDESSFRFDPDLDETAGPSDTTANFSDISGLFPPPTPPVIPPSTQMQVDRKEKARIFMEKLLQEKKAKKLQEEEERSKLEEETRKKAEKISESLSERKNTGRSDRREEAPKGARSLDEIINNRINSLLSESGFEPVEEMKRTDEDRERKRHRKRSRSRRRSRSCSPRDRSREHKKSRKSGRHHRSRSRSSSRDRHRRNRSRSRDRRR
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRIGLTGNIGCGKSTVAQMFRELGAYVLDADKLIHSFYRKGHPVYEEVVKTFGKGILDEEGNIDRKKLADIVFKDEEKLRKLEEITHRALYKEIEKITKNLSEDTLFILEASLLVEKGTYKNYDKLIVVYAPYEVCKERAIKRGMSEEDFERRWKKQMPIEEKVKYADYVIDNSGSIEETYKQVKKVYEELTRDP
The following text describes a protein:
Function:
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MPACVTCCRNCFSRGSRPSERRVKMMTRFPALHTLWILLFSYLTMEVMATEHIQEFACFTDYAEKLVCHWKVPEQLNCSKDFLLYYRKELFPPRNVCVPENGEESSMCTCTIYPDYFVSGLTYILALQFNGTSMWNSSVTPAQVVKPRTPKNLAVEKNENGNFNLSWEESYAASSMLFGQPVIYEVKYWSKQQPEKATVTSINYQAKSFEITTSSLQRGYDYVAIIRCNYTDYPAYWSDWSDGVEFHYDYQVTPEDILHMAVPISCILIMAVAVICYFCFTKMKKEWWDQIPNPAKSHLVVKNVKFSVLSYIDEMKFPFYDSKPSHMEKQTSCKSCLAQSLSSQNFKEKDNIRNVEKCCSCCSKPGEWFPKGINAVLTPETVLVEESIEICERLTDVEAENQEKTSDQITVFEPCECSVSTLREHAEHNDALADMFMELLADEKSMQDDRDPDIIMSETFQKLESENPSQKNSEESAVQSQRSPGISHGVSPFTEASQDEYNCSTTSRKSAQSEESLESGYRSSSTNSASLDARDSPCKLQQSLLLCSSESQHDSSVLIWESLNKPAFDRISSPAYKSSDTLISPSVEPCGSAYKSFHAVMSPSVEPCGSVYKSLDTLMSPSVEPCGSAYRSFDALVSPSVEPCGSAYKSLDTLTSPSVEPCSSAYKSFDALMSQSVANSSLNMHFENICLLPSLTQSSEARANNGVPAFPPEEETCKQAVYQNLQKEGSVLSCPAGPQPSGYKPFDAAVKCSAAHFDSSSEVISKSLYEPLVHLLYNNLEETSPDNITRGPDQKVDGHECLIVQDFDSGIAPGVGSSEKVTHSSSDDSLLIVSSHELLSDTKDENISRDKQLLHFLDLSCQDFNGERAIKETKHNDSNCCGEGVQGSSSDRVSTDFQRAPHDHLRKFGNAGENKEVVNRRCSCSAANLLEASLDGIGLTLKTAEEPLELLVSDKLSAALFVDNPHLSDSHTTPSDNSGLAPAVKKRPSELLRENNRKNEKKVELLQALAQEDSCYMKVV
The following text describes a protein:
Function:
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
Subcellular Localization:
Secreted.
Sequence:
IQYVLSRYPSYGLNYYQQKPVALINNQFLPYPYYAKPAAVRSPAQILQWQVLSNTVPAKSCQAQPTTMARHPHPHLSFMAIPPKKNQDKTEIPTINTIASGEPTSTPITEAVESTVATLEDSPEVIESPPEINTVQVTSTAV
The following text describes a protein:
Function:
Involved in the spindle assembly checkpoint. Involved in ER to Golgi vesicle-mediated transport by either facilitating USO1-dependent and -independent tethering or increasing target accuracy of fusion events of COPII-coated vesicles.
Miscellaneous:
MISCELLANEOUS: Present with 2730 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Note=Localizes to cytoplasm in a punctate pattern. Association with the cis-Golgi requires N-terminal acetylation and is probably mediated via an N-terminal amphipathic helix. The localization to the Golgi is MAK3-dependent and SYS1-independent. Localizes to the Golgi together with BUG1.
Sequence:
MFRIAKNLVRTFEQSVQDTLALSQDSSNLDAFFQSIPPNLLSAQLESPVDAVSEGVKHTNVNETLSGLRIVWVDEMQFQLQSFFDYIVGFNDDPVPVVSNQHGFSYPDYRRITSIFNEHCGRTLKVNIWSAKGGTFRDEYISIISKESDDLDDVSLNHDERRPSSGEAHQFQALGFKVQWTPLIASTFTYHILNVNIPDGPAQSAGLIPDEDYIIGCQDGLLATGGETLLQDIVRSRANYDLVLYVYNKVSDCVRPITVHIGPDGRLGCNVGYGFLHRIPTVKHCPQQAQQQGQDDNPVPVPVPVESETAFVPSAFTAPPVPTKKKSKNKKGTQPLAMDDYFNEGRDKSSTAAKSAESDILAPPPQKQSSSD
The following text describes a protein:
Function:
Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Golgi apparatus. Presynapse.
Sequence:
MSCVWSNSGLKRAGKISECGKYCGPTANGPTISFSSFRQSFTSNVNYLKRRFSSGDLSSECEDGEAPVDPYSKAPPVTAQPQAPPPPPPSQTSTVGDLSLNLRPGSKTTSAPSSPAKSRESLLQRVQSLTGQARDQGASILGAAVSSATRVTSSVSGRYLTLLVVDDQNTDWSKYFRGKRIGDYDIRVEQAEFKEITVTANSEGANVSMAVFRGGTRVGRSFRPDFLLVRQNLKDAGENYKKLLLALKFGGVPSINNLNSIYNFQDKPWVFGHLVQLQRRLGKDSFPLIEQTFYPNHREMITAPRFPVVLKIGHAHGGLGKVKVDNINDFQDMASVVAVANTYCTVEPYIDSKYDIHVQKIGNNYKAFMRKSISGCWKTNTGSAMLEQISMPERYRSWIDEVSDLFGGLDICALEVVVGKDGREFIIEVNDSALTLLGDSQEEDRRHIADLVASRMQAICRPRTPPSEEPVPPPVGPRGILGSLTSLTHSETPPPSASDHPSLSSVGRRDSQASQSSTVSSSGPSTGRLPDPPPRPFQRQGSQQQSTTEDTEDTMKNLRKTFAGIFGDM
The following text describes a protein:
Function:
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Vesicular and vacuolar.
Domain:
May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
Sequence:
MRTPDAHVIASMEDQPILNAAFNQDSACFAICHNRGFRVYVTDPMDLRVQREFDDGGIGVIQMLHRTNYLAVVGGGSNPKFPQNKLVIWDDLKSKPALSLEFLSPVLNVLLSRTKIVVVLQNKVHVYAFSSPPSRISTTDTADNPHGIAAFSGDTVVFPSRTPGQIQVVDLSQEGQARNLVSIIRAHKSPVRCVTLSADGSVVASCSDNGTLVRLHSTSNTALLHEFRRGLDRAVVYNMAFSPSGSRLAVLSDKNTMHVFDTSASASGAAGAANRRHVLGKVPLLPSYFSGEWSFVSARVQGQHGVLGWSSETSVVVVWISEARWEKYVIVEKKPVEGSGKDQPGCELVREAWRAFKDL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes.
Sequence:
MKCTSVNIRNVLDISLKKKIKENTNLSDDEIIIIYKRFNYISSNGKLNYDNFEKSLGILGSIQNAYLYKSIFKAFDLNNDNYLDFYEFCVAINIMLKGNKKDKLKLSYRIVNAGFNSNEDACVHKSSCMVNKFNTKEDNNMNGDNINGDNNNNHNNINGDNNNNHNNINGDNNNNNHNNINGDNNNNHNNINGDNNNNNHNNINGDNNNNHNNINGDNNNNHNNSHNNNSHNNNNKAENSLGQPLNEKNINDPINKHRNSQSIIYNINDEYNEKIKKNKKQDYSNYITYENFEKIVLSINDIKRQLLGTGDEIITSQIKYTFRSLSILCDDGIYRMNFECYKKALKCNEFLKLLGIHTKVADVFLQHELLKRKDKNKTKNGTMRNRKKYKNDSNRIANHLIIKSFSESTNTRGSIINDSTSFLFLRKQKKKKKKKKKKKKKKEKKAILYERKSTFSSSMENKSQNKSQNKSHNKNIKSVSRILSRVNKLSSTELIPNECDHKPNEEVKSTSDVLTPIFFNNGDEKMNHDTDGNMVYHKNNVDDNLVDGDVVSQGKRCSFFSSCENKKNEENKSITFNDINSGNINTNSCIMNNMIVTKESNEEIINEEAQSSYIYNKNIFCSKYNTKKDKNEPLKCDLFECSFINNDKNIVRDEDSNHKNVRKTDDYFIIDDNNIFDNGPIIISKNKTNDRERKLLKTFSSSSLKKKSLLKNYNYHIKKKNKDPNVEDTNMLYHDDIKKEYDHKVTKNNKNTCNNNYYNNVSFNSSAYYEYHSDIDLIHFSNNLKKKKKKNVTSPRPSSKEYERKVTYHKECCSNERMKNIKVNESDLGMFCVNNDKTNIEDVKEKKACDVLNRGCIKEQVQCKISEFENDKGNEIYMQEFKKCIEKYKEYVNQGEGHLKDEEEEKNDDEEEGEDGEDDEEENDDDDDDEDGDDDEDGDDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDDNDEKSNIKIENKKDVPNIHNNNDDDGINCCTNLFKDDDTLSALEKNVTNNNLIKIMSAKYLYHKFLEYKDFMKNNTTLFSHFNKIYQHEDDKINTDNKDVLNYRPKHNNDINYYNIPCEDQIKSDEKKSLLNVEFGDDIIKKKFFISSVNSHYVMINNNLTKEQMLYLIRNILMSIEDYLKKEKNRDYNKIFFLFFSIFIYNTQNGGDQKEMHEDEKWDHTNINEDKNVEKNDDYKNLSNNENSVYYNTMLRESLWNKKKYIKLNIFKNIILVISIVRYFLHTITISQKYTSSYDSLDDSNMIKSMNSLKLNEINILLNRASEILEKYSLGSVENKKVYINKSNYYNSSKKGKLSVSLRQNKQKKTFHRILAVYFGHERWDLVMNMMIGIRISSIKKFSINDISNYFHHKDVIQLPTSNAQHKVIFKNYAPIIFKNIRNFYGIKSKEYLTSVGPEQVISNMVLGNLSTLSELLSEGKSGSLFYFTSNGKYIIKTVCRNIHNLSKKLLPKYYEHIKKNPDSLLTRLYGIHSIKYQNNLGRKKKKIYFIVMNNFFSSIVEIHRRYDIKGSLVGRTVPETKREDHTIALKDVDIDELGDIINIGPENKERLLKVLKADADFLKENMLLDYSLLFGIHYRELSKDVVNWEETKTNQINHIYDYKGNCIASRPFHQCDYGGIISVDKKKIFFFGIIDIFTKWSIKKKFEHTFRTIQKFDGKNISCIHPNAYAKRFVTFIENHMK
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCEFVIMPPIPARPTELHELGRAFAQHYYTKICVGRQELDQLYAPDSVMTFEGLECSGREAVMAKLKALTFKSIHYSITSIDCQPTGLPNTVFLMVLGQLKTDEDPPHSFCQTFILRGFEASFFIVNDVFRMVLHNA
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSGPSSSPHVMQSGATSGVNIKLHPLAILNISDVYTRAQCTSTGSEVPKLIGALLGTESNREIAIVNSFELIYHPSVMSGEDVDMSDSGSSGGKYVLNTDFLETRKDQFKQVFPTLDVIGWYSVGKEPSSDDISLHAQFASSVETPIFLLFDPDPASGTQALPLKIYESATVTDTTGEISGEGKFVELEYGIETGEAERIAVDGVAKGGAGEEDTAVAHLTTQRNAIKMLYDRIEILLKYVTGVVNKSAKPDYSILRRISSLVATLPTMDAGEFREELITEYSDVQISSYLTTLTKQLNVLSEYAEKHSLVYGQKEDEFMGGPSMGLRGGRQMNFDMGGGRRRR
The following text describes a protein:
Function:
General transcription factor with prominent roles in controlling histone levels and stability. Binds and regulates the activities of many promoters, including those controlling the expression of all four types of canonical histones. Is also involved in the centromeric loading of cnp1 and maintenance of centromere identity. Moreover, regulates the expression of cdc2, a protease capable of histone clipping.
Subcellular Localization:
Nucleus.
Sequence:
MRSMKPPGFSSDLMDEHSVDLLNGSILAAENPSKREVAQDVPGFERKPTKVRKPRVKWTEKETNDLLRGCQIHGVGNWKKILLDERFHFTNRSPNDLKDRFRTILPEDYKKFYPNAKTHMGRPQKIPHTVGLSKSTRKERKQFTPEEDERLLEGFFLHGPCWTRISKDANLGLQNRRSTDLRDRFRNAFPERYAAAGFKLKNNPGNRSKYYQNNMVNDATTPNDSSTTEAAAAAVAAVAAVAASNPNASPQQTTEQPASDELLDWPHHNLPSQFFTSQRNPNYSTDSFLLGQSLSDPFNHTLQSFHPYESLFSAGQPPSLPISPSTSQNSVQPFPFSIQQPPLHLEPPLSSNTLNSSTLPQPNSTDFNTFPPLPSTPRISSEDIPWDNRG
The following text describes a protein:
Function:
Has apparently no tyrosine kinase activity in vitro when expressed in mammalian cells.
Sequence:
MEGLARVFLIGGASKAVRYDEQTTIERVIHVVARGIGISQVAVAHFALRLVTGPSPQTAGSGDSLWLHPMLRITQLPHIYARHLPIGVCDEIKLEMRMRFMPQSVYELQATDSSAFVYLHEQVVDEFFSHVAWRSSVEVALEVAALKVCRDFAEHQHNKGADHHLEDLDIEACIQSLIPNVLHNPGFKHSHLKKTFTAYIKKFSATSPNESIIRSLALLLEVVKFDVELFKASLGAGWTKPVELVVGPHTGLSYRLNERCDSSRLLELRTIAEITIRKMENGSEKTLMQLNLSGAAKPVLITLSTEELSQSLAHLLDGYQMLYNQRDSVFKLKGIERCETLTMHEATIRPKTPNNIDSNIRLRRELITLKELIGGGQFGNVYKAVYHDLEKDERIAVAVKVCKTDAEPADTQLILQESSLMRNFRHSNIIQLIGVCVDQPMWLVLELAPKGELREYLQQEKDWLPLRILTLFCSQICDSLVYLHSTRFVHRDIAARNILVCSPQCVKLADFGLSRALDYDAVYTASRGKLPIKWLAPESVNYRQFSMASDVWMFGVCMWEIFSLGVKPWAGVTNSDVIMHIEQGSRPPCPEKCPTALYNFIRSKMWAIEPHKRPTVDQIYAIIEDVRQQIIQNIPPEQIIVGKPMTAAGVIVAEMSSLPGLTLYRTMEDQKRQAEEDAKWLEQEDDEDEDDQDIDQIPSTSHSSVENIRTSNGYLHHTPTSTRSLRFEDKTSRGLRRSVDGVCDAVTKLQNSFNNLTHNDDFLHSVKEVTSQLREMLIVASGMRDRVTTTTQRTDVDMTKTLIANDMKQMSRVMGKLQVNGHQATYNTLRRDVVRICGELAVNCTTLQLQLTQPPLENEFSSLLSNC
The following text describes a protein:
Function:
Catalyzes the attachment of tryptophan to tRNA(Trp).
Subcellular Localization:
Cytoplasm.
Sequence:
MTKPIILTGDRPTGKLHIGHYVGSLKNRVLLQEEDKYDMFVFLADQQALTDHAKDPQTIVESIGNVALDYLAVGLDPNKSTIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEISQKGFGESIPTGFLVYPIAQAADITAFKANYVPVGTDQKPMIEQTREIVRSFNNAYNCDVLVEPEGIYPENERAGRLPGLDGNAKMSKSLNNGIYLADDADTLRKKVMSMYTDPDHIRVEDPGKIEGNMVFHYLDVFGRPEDAQEIADMKERYQRGGLGDVKTKRYLLEILERELGPIRERRIEFAKDMGEVYNMIQKGSERAREVAGQTLSEVKGAMGLHYFN
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Nucleus.
Sequence:
MLCASGYYDHCPIHRVIQNYLVQTGDPTFTGDGGASIYGEKVQVEPFGDFSEPGYLAYAETHEVGSQFFITAASTPELAGEYTAFGHVIYGLNNIIAFSRMPTFEDHQPIRPAAIKSITIHANPLAE
The following text describes a protein:
Function:
3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation.
Subcellular Localization:
Nucleus.
Sequence:
MEFLKHYEDDEDQDDENNTKDENVNKINKRQHFEIENVIDEIPDLPLSFFENFKKIKHYSSEIIDETNKKTRLFEHVEGNYPTFIYFKVPTKSRNDIKELIEQVKEIGNEINIKQDTETCFHISISRTFPIREHHIETFTQELKKTLKNQRSIDIQLSKECCVFINDNQSRIFLSIPINQSFKSNILKLIERIDSCLSLFKFPKYYDNPEPHLSISWSLITNNNNETNDENINYIPLNKFKNKEIIRDNLKLTDSFKVSRIFWNIGKTESFIDLQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
Sequence:
MLAERRRFRLPWRHAQGRDMMAGGISIHAVDVASGRPAQGLRVEIWRIDPDSSRIADGRLGANGVLDHPIVQGAGVTAGEYEVLFHLGEFFADSDGFLTVTPFRFRIKNVDEHFHLPLKFTRWGYSLFRGA
The following text describes a protein:
Function:
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain:
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence:
MSIDLDWDGMINSDEIDVAEWLRSLLDKQFQQLDLPRNIRSVSITTLSLGTIPPELEIKHISDPFPEFYAEEEAAADSHYLPPLHPPQQRRSAPSTPHIHTNTTNPIDRGIASYFHPLGSAPLMSGLRTPLNIPSWATNGHTRTSSRLPLNTPIEAEIVESVRESTAPRTPEEREQQPVPEDREDDLQVLFRVKYTGDIRIGVEATLRLNYPSDDVVLLPMKLHLSHININSLAIMAYIKKSIYLSVICDLDDSDHAVARTGRERLDIIRDVKIDSEIGHHDTNGAALRNVGKVDRFIVDKIRSLLKAEIAWPSWIKVSMEDEDSDDEEGEEEGDQEDEH
The following text describes a protein:
Function:
Toxin secreted by the H1 type VI (H1-T6SS) secretion system that acts on bacterial target cells. The producing bacterium is protected by a cognate immunity protein.
Sequence:
MSGLPVSHVGEKVSGGVISTGSPTVHVGSSAVGLADRVSACVPLVGKPVNPMLGSKLLPEEVDFALAAPDTFTFARGYLSSNPRIGRLGRGWWLPGESMHLELSEDACVLVDAQGRRIGFPALAPGAQHYSGSEELWLRRGGSSGGEAQAWRGRWAAVPAELQTQEGSVLVLSGHSYLHFQRCPDGIWRLQASFGRAGYRTEFRWSGRGLLTGVRDSAGRSYALVYQQACEPSEGDDGLRLFGVILASHDGPPPDYIDPQSPGLDWLVRYQFSDSGDLIAVRDRLGQVVRVFAWREHMLVAHGEPGGLEVRYEWDVHAPHGRVVKQIEAGGLTRTFRYLRDATEVSDSLGRVERYEFAGEGGQRRWTALVRADGSRSEFDYDLFGRLVAMRDPLGRETRRRRDGQGRMLEEESPGKARYRKRVDEETGLLVELEDAMQRRWTFERDERGNATTVRGPAGSTRYAYEDPRLPDRPTRIVDPRGGERRLEWNRFGLLAALTDCSGQVWRYDYDNEGRLVASSDPLGQLTRRRYDPLGQLIGLELADGSALSYEYDALGRQTRIADAEGHATLFSWGHGDLLARVSDAGGGELSYLHDEAGRLVALTNENGVQAQFRYDLLDRLVEETGFDGRRQRYRYNAADELIAREDADGRETTYAYDRDGRLASIRVPATEHAPALVERYRWLADGRLASAGGADCEVRYTYDEVGNLRLESQVHADGWVYSVEHSHDALGVRQTSRYGDAPPVAWLTYGPGHLHGALVGAVELAFERDALHREVRRDARRDGQDDALFTQERQHAPLGRLQRSRLRLAGGFDWQRGYRYDGLGQLVGIDDNQYPSVRYEYDLGGRLLASRRAGAAASTYRYDAAGNRLEGVGEHAREDARQAFAENELYRSGFSRSETRASQAGEGPARWAGNRVERIAGNRYRFDALGNLVERIGADGERLRLAYDGAQRLVHLTRDYADGTRLEARYRYDALSRRIAKVVLRDGVEQQVRFGWDGDRQCAEAFARELRTTVHEPGGFVPLLRLEQACEPDPPELLQLRQAFAAEGQPLPAQCVPALGEARIAFFHTDHLGTPLQLSDERGQLRWQGVPDDWRAVAPERQPGAQPIRFQGQYHDEESGLYYNRYRYYLPEAGRYASQDPLGLGGGPNPYAYALNAPTLAYDPTGLIIPLVVIGAFAARAAIGAALGAGIELGMQTGKQVLGQMKDNWDSDRDLTDIKWKCIDINWKHVGASAAIGTVAPGMLSTGKTVVQSAKAIRTLSGQAANTANRAAKLAARKAAHADTIKKAVATQAAWQTGKQIVKCPLKDEEEECPPQ
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEETINDKVNKIEKTNNSDRKKDEEIMNKIKNYKILNNNNNNNEEEEEEEKNIKEYPNNNIINKENHNVLIKENYDVTNKNDDTTKINDDNSNVKINCESSNEKREVSDLNTYSDNDVNVNINNSSNNIEKENPPKDKHYDNNINKISSYGDNKQNNILDDTDMSIHNNLNDTSNEKKNVIISNEDIIQNNNSKTCGNLKNYYKDLPTVIIVIGMAGSGKTTYVGSLYNYLKVEQKKKVYTMNLDPAVKYVQYPLNIDIRDSIKYHEIMKEYKLGPNGAIMTCLNLFATRFDKVIEILEKRKSKLHYIIVDTPGQIEVFNWSASGNIILETLSVSFPVVINYIIDTVRCERPITFMSNMLYACSVLYKSRLPFLACFNKTDIIKHDKCIEWMTNYDTFNDDVLNDESYMASFSRSCALMINEFYEGIKTVGVSSKTNEGFNNILKNLQILKEEYLNEYVSSIEKQMKKIKQRKEKDVKIKMEALLMEKQKEISSSKS
The following text describes a protein:
Function:
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Membrane.
Sequence:
MRLTNFFGDVGREMKKVSWPKKDELLRSTATVVATVVFFAIFFAVVDMGISSLIRLILG