lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein.
Sequence:
MYQWRKFEFFEEKYGGKSKIPEDVSGNINCCSSGRGKVVIGSDEGHVSLLDRGLHFNFSFLAHSSSVLFLQQLKQRNFLVTVGEDEQIAPQQSAMCLKVFDLDKMQPEGTSSIVPDCIGILRIFTNQFPHAKITSFLVLEEAPPILLIAIGLDNGCIYCIKGDIARERITRFKLQIDNNNVSDKSSSSITGLGFRVDGQALQLFAVSPNSVSLFSLQSQPPRRQLLDQIGCNVNSVAMSDRSELIIGRPEAVYFYEVDGRGPCWAFEGEKKFVGWFRGYLLCVIGDQRSGKDTFNIYDLKNRLIAHSLAVKEVSHMLCEWGNIILIMNDKSALCIGEKDMESKLDMLFKKNLYTVAINLVQSQQADAAATAEVLRKYGDHLYSKQDYDEAMAQYISTIGHLEPSYVIQKFLDAQRIYNLTNYLENLHEKGLASKDHTTLLLNCYTKLKDVDKLNVFIKSEDGVGEHKFDVETAIRVCRAANYHEHAMYVAKKAGRHELYLKILLEDLGRYDEALQYISSLEPSQAGVTVKEYGKILIEHKPAETIEILMRLCTEDGESAKRGSSSGAYLSMLPSPVDFLNIFIHHPQSLMNFLEKYTDKVKDSPAQVEIHNTLLELYLSNEMNFPAVSQASNGVDISLQAKSGAGRKSKAKSNGKVIADRKDIYKEKDRVERQEKGLLLLKSAWPADQEHPLYDVDLAIILSEMNAFKEGLLYLYEKMKLYKEVIACYMQAHDHEGLIACCKRLGDSSKGGEPSLWADLLKYFGELGEDCSKEVKEVLTYIERDDILPPIIVLQTLSRNPCLTLSVIKDYIARKLEQESKLIEEDRQAIDKYQEDTLAMRKEIHELRTNARIFQLSKCTACTFTLDLPAVHFMCMHSFHQRCLGDNEKECPECAPEYRAVMEMKRSLEQNSKDQDQFFQLVKGSKDGFSVIAEYFGKGIISKTSNGTSGALRSGSTSSSSGF
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MERKDVKTHPANRLLRGLTMTTAYPPAAASPFTIFYAGKVRVYNAIPPEKQAQAIMLIATAVAGATKVSGDRTPAAAEKAPAIVGPSAAAAAAALGPVLTRSLSLQSSTAGGQPQPQLMPTASDALCKLQDELPMARRHSLQRFLEKRRDRLANRAPYAAEKSSDMEVASEERPQLT
The following text describes a protein:
Function:
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence:
MDEGGWDKTLVQSQQPPAAAPSGMDEKPSGKERRDAGDKDKEQELSEEDKQLQDELEMLKDTSLYRPALEEMRRQIRSSTTSMTLVTKPLKFLRPHYGKLKEIYENVAPGENEHFAADIISVLCMTMSGECECLKYRLVGSQKELASWSHEYVRHLAGEVAKEWQELDDAEKPLLTLVKEIVPYNMAHDAEHEACDLLMEIEQVDMLEKDIDENAYTKVCLYLTSCVNYVSESENSVLLRCALGFSRFPKALRLALMRNDMELVEDIFTSCKDVVVQKQMAFMLGWHGVFLELSEDVEEYEHLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFLLTDDGNKWLYKNKDHGMLSAAASVGMLLLWDDYIKSGILLACGIVNSGVWNECVPALGLLSDYVLHNSNTMRLGSIFGLGLAYAGSNHEDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDLKDSYARWFPLGLGLNHLGKGEAIEAILAALEVASEPFRSFANTLVDVCAYAGSGNVLKVQQLLHVCSEHFDSKEKEEDKGKKEKKDKDKKKTPADMGAHQGVAVLGIALIAVGEIGAETALRTFGHLLRYGDKLSHDADPEVSYNSIFAMGMVGSGTNNAHLAAMLHQLAQYHAKDPNNLFMVHLAQGLTPLGKGTLTLCPYHSDWQLMSPVAMAGLLTVPLSFLDVRNIILGKSHYVLYGLVAAMRPRILVTFDEELRPLPVSVHVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILESFVILRKNPSYDL
The following text describes a protein:
Function:
Essential transporter for growth and development under abiotic stress. Mediates shoot branching by promoting the outgrowth of lateral shoots. Required for salt tolerance via Na/K homeostasis, at least partly by regulating SKC1/OsHKT1;5. Necessary for hypodermal suberization of roots, which contributes to formation of the apoplastic barrier.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAMTKEVNLTPFSSPSPLLGHQYCHHPLATAAAVDPCHFVLSFTDLSYSVKEPRSFPFFRKKNNETRPEALRGTRKLLDSISGEVRTGEILAVLGASGSGKTTLIDALANRIERASLRGCITLNGDRLEGRLLKAISAYVMQDDLMFPMLTVEETLMFAAKFRIPRSVSASKMKERVQALVDQLDLRSAAKTIIGDEGHRGVSGGERRRVSIGTDIVHDPIILFLDEPTSGLDSTSAFMVVQVLQRIARSGSMVIMSVHQPSYRILGLLDRLIFLSRGQTVYSGPPQGLPEFFAVFGNPIPDGGNPAEFALDLVRELEDTAPDGAKDLVTLNALNHQARARTSATAATGSCLPLQEAVRNSIATGKLVSGAMIDGAALASYANPFWVEVSALTKRAIINMWRMPEILAFRLGDMLVTGFLLATIFWRLRDTPKDVRERIGFFAITMTTIFFTSGDTLAVFIQERYIYMRETAYNTYRRSSYVVANAVTTFLPLVFLTIPLAFITFFGVGLSGGMDGLGFFFLTILATFWAGSGFVTFLSGILSHVVLGYTVAAAVISYFLLLSGFFINRNRIPDYWIWLHYMSLVKYPYEAVMQNEFSKDLSKCFARGVEMFDGSALGSLPTAKKVEVLTVIGQTLGMNITNDTCIITGSDVLQEQSINQLNKWSCLLVIVAWGFFFRLLFYISLLLGSRNKRK
The following text describes a protein:
Function:
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Subcellular Localization:
Host nucleus inner membrane. Note=Remains attached to the nucleus inner membrane through interaction with NEC2.
Sequence:
MSSVSGVRTPRERRSALRSLLRKRRQRELASKVASTVNGATSANNHGEPPSPADARPRLTLHDLHDIFREHPELELKYLNMMKMAITGKESICLPFNFHSHRQHTCLDISPYGNEQVSRIACTSCEDNRILPTASDAMVAFINQTSNIMKNRNFYYGFCKSSELLKLSTNQPPIFQIYYLLHAANHDIVPFMHAENGRLHMHVIFENSDVHIPCDCITQMLTAAREDYSVTLNIVRDHVVISVLCHAVSASSVKIDVTILQRKIDEMDIPNDVSESFERYKELIQELCQSSGNNLYEEATSSYAIRSPLTASPLHVVSTNGCGPSSSSQSTPPHLHPPSQATQPHHYSHHQSQSQQHHHRPQSPPPPLFLNSIRAP
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLKKFLISSIVKPTFQSRIIASTTLNGGAGRATFCSVNSINPNPTASQIKVDQEDLEVGEHLVIDDPNQQHIKSFLNGVEFNGKSVNIYRPSRNTMQTGTLRTKKWVIELPFNPKWNDRLMGWWASKDTLNQLNLRFNSETDAVAYCKEIGLNYNIVEEDVTLRKKKKYGHRFRYRGDLVGEKEREVGIN
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.
Miscellaneous:
MISCELLANEOUS: Present with 1900 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MATKQAHKRLTKEYKLMVENPPPYILARPNEDNILEWHYIITGPADTPYKGGQYHGTLTFPSDYPYKPPAIRMITPNGRFKPNTRLCLSMSDYHPDTWNPGWSVSTILNGLLSFMTSDEATTGSITTSDHQKKTLARNSISYNTFQNVRFKLIFPEVVQENVETLEKRKLDEGDAANTGDETEDPFTKAAKEKVISLEEILDPEDRIRAEQALRQSENNSKKDGKEPNDSSSMVYIGIAIFLFLVGLFMK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MELPSYSKQLLQQLYTLCKEQQFCDCTIFVGTVHFRAHKVVLAAASLLFKSLLDSTDTISIDASVVTPEEFALLLEMMYTGKLPMGKHNFTKVISVSDSLQMFDVAVSCKTLLRDLISCSTQDQVEVSAHAADSSGSSAEADNLPQSEKPAAEGKTDALHPSGPGEAEMEADISPPEQGLTVNHTWLCQNVMLSSSESLREYSGSCAAQPACAEHGCCVEVEPAEPLEKKGRVSGLAAESKSCKLDFFLRYESVFSEALSDAQAVLRRLEECREIDASQREVVLTCLAEAGEQSLFTTLLGKVKDAHTLDAQTLVSLLKLFQDVNPKLRAALLEREQSSGEVLKQTESAEEGEMLTARLLGCKEELIQSVTQLSPIVEFLEAAEEGFLTASEKRVVLNCCEGRSQREAMDSLLKKVEEEKTLKAESLVKLLRAVKASFPGLHLLLHNLEVKTNVSDGKDCHCSLHHLRELSLRTLHSKWSLEDYGAQLLRRYQERLVEHLTDTQILLRGISAAQSLAPADREAMEQIVKCETGSGGFVSLVSAALEEQSLSVSVVWQLLLAVREAELPLNVLMEEIQKEPGAELFFQAVATSESTAIEIILRHSELISEAIKQRANQEGLAPGEAGLTEAVKELLSISAQKESSEASLKAALSAAQEKSVPAIKICQLLCNVHESFPDLQPVMQELGHVGLLTEGSGEKPGIRKWKVNSESQVEALDKEEDRAGGAAIKELKEPQEKASSKKSFICKACEKSFHFFCRLKVHMKRCRVARGKQIQCRECTEVKLTKKELEKHQLEVHGAVGTAKKKKKRLPVSCDICGREFAHASGMQYHKLTEHFDEKPFSCEKCGAKFAANSTLKNHLRLHTGDRPFVCKHCLMTFMQASALAYHTKKKHSEGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRECGKGFRQANGLSIHLRSFHNIEDPYDCRKCRMSFATLQEHRKHIHEAHSREYHPCPDCSKVFSAPSLLERHMVTHVGGKPFSCDICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLHCSSCDKTFSSTAAHRKHVKAEHSDVKFHDCEMCKEQFPTLSLLQVHMKCRHSGALQHHVTTEHFKQTESTFTCGLCGELFTSQGELEGHCSAEHPKVIFTEAQATTTQIVQVIQTSEQGAAEHIISFDEAQLPGSHVVVTLPESQASQAGSELVMVSMEDLFDDKVTLICEETQ
The following text describes a protein:
Function:
Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates. May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Subcellular Localization:
Melanosome. Membrane; Lipid-anchor.
Sequence:
MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGKGKPVPTQGSRKGGALQSCTII
The following text describes a protein:
Function:
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHVLVALAACALAYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFSLQHELLPAYALLMLIGVMGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGIYSLAVMIGIPVVPIGIGFGALFALAITALWIWQRRH
The following text describes a protein:
Function:
Plays a role in the export of secreted proteins in the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTLQWVAVATFLYAEIGLILIFCLPFIPPQRWQKIFSFNVWGKIATFWNKAFLTIIVLLIVLFLDAVREVRKYASTPAIEKNSASRPSAYEHIHMKLFRSQRNLYISGFSLFFWLVLRRLVTLITQLAKELSNKGVLKSQAENTNEAARKFMQENEKLKRVLKRYGKEEEHILEAENKKLLEDQEKLKTELKKTSDGNSLSKAQNDVMTLKMQSERLSKEYDRLLKEHSKLQDAKTSVHVVWKR
The following text describes a protein:
Function:
Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons.
Sequence:
MAATDASRAAQKRVLRVLALHGYRQNERSFWERTGALRKVLRGRAELITFSAPLVVPDPDAEPSDGDPNSSQDESRGWWFSNPQQNSFDAMEESNTCSGLEASLDTVAKAFSELGPFDGILGFSQGAALVAIICALKQHGDPRFHFNFAILVAGFKSRSSEHTKHYQQPNTVPSLHVIGETDRVISADMSRELVSHFENPFIVMHPGGHYVPACAPQKKVYWEFLDKFLS
The following text describes a protein:
Function:
S-adenosyl-l-methionine-dependent Diels-Alderase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. IliD catalyzes the Diels-Alder reaction that converts the acyclic 2-pyridone intermediate to 8-epi-ilicicolin H. The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain. The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone. The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H. 8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (Probable).
Sequence:
MTSTEAAGTGKAPAIRANPALQTYYESQESYLVYEVVLRGSHHFGFYEKDTYWPFPVGRSLERMEAKLLSALALPSGSQILDAGCGFGPVAISMAKKGMRVTAIDIIDHHVTKARRNVEKAGLPKGQVTVEKMDYQHLESIASESHDDAKAAATGFFRILKPGGRIAFFEAQRSRTSGDYDEGDELAGHLKLVNEYTAMPTNELSREDYFKDLLEDAGFVDVEFTLPPGTREPREHWSYSALKA
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MQRQAVYMRRSLFDQEYVDEQFTQLEELQDDANPNFVAEVVNLFFTNSARFIRNIELALIGAKRVKRGCSHFEEYCNQRNIDGCKRAFQGVKQEYATLKSKLDAYFQIAREAS
The following text describes a protein:
Function:
Together with tsc1, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNNKSLLDLSSEPAIKDTDILSYFDANLPFKKRHQIVRSIYHGLKYYIYSSTSIIQVWQNIQDFISTKNDNAAFRELVYNLMMRYVSTQKHLSIIERHTFFQTIEKDPFQDIAELQLRLKSLSVLTDEGHKISGIENRVGPLLSAWFNQYLQWQSQATELQGKDADSKLVHLLFFKSLFKFSTNLVKFQWFLVPEPQMLQLVNSVVQICNHARLEDVVTEVLMFFDSMIRYSVIPKASLYDTVLILCSTYISTYSYSKLAQSVIFNLISSPVSNLAFENVFNILQYNRSNVNAVRGAVRLMRFLMLQEVKNDAIASITLSSSIEFTEFPLGFNENVDFEILGTVYLFLRTPSILNRLNFLDWHRILNILMYCSQYLPLKASTSKEAFSKTAAFANIYDRVLDFLDFEALIPLLQQFQVKLVFFLKDVLPVLKPKIRKKLLRLFETYNLIFPCNQYWVFNLEFLLGIYQCKTFDLEDRALLFKLVEDACSVADENSAPILCSKFLFPVIESFSKESDDCVVSPVYNMLFFLSVNFQNPGLKDCIDHIFQQLISDTSSVTVRRLATSTLIRLFYYYYDLRDAVPIQETLAKMLEILETPSFPFVSRMLCLQFFLRFRANGTSIYICENIDLNEPFKVLNVDSELIPAVYPISDSFVNSATVEKHIWERKENDLIKISNHSTEYGKDFVTFPTSSLLRFYRKSMATESNWTILMFMITHLADQISNRSMFIGALEEIYNLLDFMCDIVFERVSISAEIPSNIRKANIMIPILQNVQMLFVYHDQFSRAQEDELVSVFFAGLQKWNEACHVSIHSLMLCCYELPVSIRKQLPAILVTLSRLITKPDLSVHILEFLCSLARLPDLIANFTDADYRQIFAIALKYIQHRDFTKESKDSNDTESILKNSYSSYVLALAYSVLQIWFLSLRLTERKKFVPWILRGLKLASEGKPLEDLCLVQYDMMQQFCYSNSDINNQTSTFVDSDVESETWIRGNSLFTINVSVNSGFLEAVIRRPTGTTQYTFRNEASLQKFLWEENLTSSKALTRGLLCTPSSFVSHFLDPHGISLYNQPLLLPSNDDSVRRAISVFDRIPVIESLKAGLVYVGYQQRREADILANTNPSEDFLTFLNGLGTLFELKTDQKVFAGGLDRENDIDGAFAYCWKDKVTQMVFHCTTMMPTNIEHDPGCTLKKRHIGNDFVTIIFNESGLEYDFDTIPSQFNFVNIVITPESESIRRTGRQIKFYKVKALTKYDIDFSLFRRYKIVSSDALPAIVRDVTLNAAVFSHIYHRSAGDYVHIWAERLRQLKRLREKFQASVLPEDYNLDEQTKTKLQNGTNFSDFTSYL
The following text describes a protein:
Function:
Catalyzes the first committed step of 'de novo purine biosynthesis from glutamine. Required for chloroplast biogenesis and cell division. Confers sensitivity to the phenyltriazole acetic acid compound [5-(4-chlorophenyl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-acetic acid (DAS734), a bleaching herbicide.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MAATSSISSSLSLNAKPNKLSNNNNNNKPHRFLRNPFLNPSSSSFSPLPASISSSSSSPSFPLRVSNPLTLLAADNDDYDEKPREECGVVGIYGDSEASRLCYLALHALQHRGQEGAGIVTVSKDKVLQTITGVGLVSEVFSESKLDQLPGDIAIGHVRYSTAGSSMLKNVQPFVAGYRFGSVGVAHNGNLVNYTKLRADLEENGSIFNTSSDTEVVLHLIAISKARPFFMRIVDACEKLQGAYSMVFVTEDKLVAVRDPHGFRPLVMGRRSNGAVVFASETCALDLIEATYEREVYPGEVLVVDKDGVKCQCLMPHPEPKQCIFEHIYFSLPNSIVFGRSVYESRHVFGEILATESPVDCDVVIAVPDSGVVAALGYAAKAGVAFQQGLIRSHYVGRTFIEPSQKIRDFGVKLKLSPVRGVLEGKRVVVVDDSIVRGTTSSKIVRLLREAGAKEVHMRIASPPIIASCYYGVDTPSSNELISNRMSVDEIRDYIGCDSLAFLSFETLKKHLGEDSRSFCYACFTGDYPVKPTEDKVKRGGDFIDDGLVGGIHNIEGGWVR
The following text describes a protein:
Function:
Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.
Subcellular Localization:
Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Sequence:
MVKLGCSFSGKPGKETGDQDGAAMDSVPLISPLDVSQLQPSFPDQVVIKTQTEYQLTSADQPKKFADLEGQRLACSHPEEGRRLPTARMIAFAMALLGCVLIMYKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTEMPAIWGNSYRAGKEEHKGTTPAAMTVSTAAAAAAAEGNEPSGKPLDMREKEDPQKAEDVPSQSPK
The following text describes a protein:
Function:
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism.
Subcellular Localization:
Mitochondrion.
Sequence:
MLGRFQPFSLVRSFRLGFEACCYPNQKCATQTIRPPDSRCLVQAVSQNFNFAKDVLDQWSQLEKDGLRGPYPALWKVSAKGEEDKWSFERMTQLSKKAASILSDTCALSHGDRLMIILPPTPEAYWICLACVRLGITFVPGSPQLTAKKIRYQLRMSKAQCIVANEAMAPVVNSAVSDCPTLKTKLLVSDKSYDGWLDFKKLIQVAPPKQTYMRTKSQDPMAIFFTKGTTGAPKMVEYSQYGLGMGFSQASRRWMDLQPTDVLWSLGDAFGGSLSLSAVLGTWFQGACVFLCHMPTFCPETVLNVLSRFPITTLSANPEMYQELLQHKCFTSYRFKSLKQCVAAGGPISPGVIEDWKRITKLDIYEGYGQTETGLLCATSKTIKLKPSSLGKPLPPYIVQIVDENSNLLPPGEEGNIAIRIKLNQPASLYCPHMVSWEEYASARGHMLYLTGDRGIMDEDGYFWWSGRVDDVANALGQRL
The following text describes a protein:
Function:
Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination. In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSLLDPRQFLLPAFYLDPSTQAFLTQAVSNHKLGTASSFRISDILEPSPNNSTYSHDLDPSPQSVRSDLSTSPRASSPDRNSPMSKKSRKARTIFTDKQLQELENTFEKQKYLSVQDRMDLAHRMGLSDTQVKTWYQNRRTKWKRQATSGMDLLSEPGNLSAVQNLIRSSPYWANYITALPMGGQMGQMPMMGLPMPMIVPPAQHFQATSSSNSPSTHKSSESPQLDVSSNSD
The following text describes a protein:
Function:
A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain, making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly. Required for basal and heat shock-induced degradation of RseA but not for acid stress response in this strain.
Miscellaneous:
MISCELLANEOUS: Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P, this enzyme), then within the membrane itself (site-2 protease, S2P), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein (By similarity).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Domain:
Deletion of the PDZ domain eliminates the heat shock response of the sigma-E regulon, but not the acid stress response.
Sequence:
MFVKLLRSVAIGLIVGAILLAVMPSLRKINPIAVPQFDSTDETPASYNFAVRRAAPAVVNVYNRSMNSTAHNQLEIRTLGSGVIMDQRGYIITNKHVINDADQIIVALQDGRVFEALLVGSDSLTDLAVLKINATGGLPTIPINTKRTPHIGDVVLAIGNPYNLGQTITQGIISATGRIGLNPTGRQNFLQTDASINHGNSGGALVNSLGELMGINTLSFDKSNDGETPEGLGFAIPFQLATKIMDKLIRDGRVIRGYIGIGGREIAPLHAQQGSGMDPIQGIVVNEVTPNGPAALAGIQVNDLIISVNNKPAVSALETMDQVAEIRPGSVIPVVVMRDDKQLTFQVTVQEYPASN
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
Subcellular Localization:
Mitochondrion.
Sequence:
MGQQEVGRLMSRFNAFKRINTILHHLRMSKHTDAAEDVLLGGMYPWLEKWEEDPETLLIIIKGAGGKAFCAGSDIRVISEAEKAKRKIAPVFFREEYMLNNAFGSCQKPYVALIHGITMVHGQLQVATEKCLSAMPETTVGLFPDVGGGYFLAGIATHFVDSEKLGMLEEDLLALKSPSKENIAAVLENYHMESKIDEDKSFILEEHMGKINSCFSANTVGQIIENLQQDCSSFALEQLKVINNMSPTSLKITLSQACMEGHDFYEGVRAVLINKDQSPKWKPADLKEVTDEDLNNHFKSLGSNDLKF
The following text describes a protein:
Function:
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Subcellular Localization:
Cytoplasm, cytoskeleton. Golgi apparatus.
Sequence:
MASSVILGILNGRWLSLSFLFRSDGSLQKWYAAATVERIGTFDGINGPHQTVQDLMDGVAMAECLSKIASAVFSGEWLSRIKRDANHWRLKTLKQDLSNLSLPNVEKIAINCDEEELGKMLQLILGCAFFCNNREGYIKVIMELEQSVQEVIMTAIQELMTPTSQNDQSIEEERVERLEQEIHDLAVDKKELTNKCRDLENQVANLQEELTSNKELLDRYNNVESIINDPTTDIGFKFQNLHNKIELLQKQNLSLESERDEITTREERQEKILIELRQERLLLSKRAEEAQELRDKVDELSHTADKLAQSEAQLTNYKKKLDDAAGQRDQIKKLEDRIAGFVRDNAELKAKLEQQNSQTKFHNEYYSEKISQLKKDIEECKKIEEEAKVDLYGSREKCNKLEFENKKLIDEMKSLREINAHLSARKISGVVSLDDALGQALADNDSDAREKMIQLQTENESLRKRAEEAEKKLFIRENEHLIEKHNTQIVQQKEDDKDKIELKQAIENMQSKVDEQSSLLMKREREIQVQQENGNKNADIIKSMQTELASRDADIGRLKDQLTNNENDMIRLEDKYKKFLDKAKQLQALQSQIQEKEYRVRDLERQIENLKTIHEREMKLVTTAWYELGLEVHKKTMNDRLASSGGDSFLARQRQGFKRH
The following text describes a protein:
Function:
This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
Subcellular Localization:
Cytoplasm.
Sequence:
MQKRILIVDDEPAIRDMVAFALRKGEFEPIHAGDAREAQTAIADRVPDLILLDWMLPGTSGLDLARRWRKESLTREIPIIMLTARGEENDRVGGLEAGVDDYVVKPFSARELLARIRAVMRRTREDDEDGSVAVGRLRIDGAAHRVFAGDAPVPIGPTEYRLLHFFMTHPERVYTRTQLLDHVWGGSVYVEERTIDVHIRRLRKTLEPFGLENMVQTVRGSGYRFSSAT
The following text describes a protein:
Function:
Golgi membrane protein involved in vesicular trafficking.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
METQTLSNVAPTAQESPSSNLRLFQGSSHPVALFFFLFFRGLALAMYFLGYLVLSNFMLVFVITVVLLSMDLWTVKNVSGRLLVGLRWHNEVGPNGESIWVFESADPSRPKNAMDHRMFWLVLYSTPVVWFILAVVALARFEFLWFCLVCIAFVLSSINTVAYTRCDKDARRKWATDLATSAATSSLVSRFLPRAFLGRFFG
The following text describes a protein:
Function:
Transcription factor (By similarity). Binds to regulatory DNA sequences in order to modulate transcription; negatively autoregulates its own expression, perhaps dependent upon CBF beta homolog bro-1. Promotes proliferation, and prevents differentiation, of seam cells, a stem cell-like lineage, acting in concert with bro-1. Required for controlling cell proliferation in the seam cells, perhaps by repressing expression of cyclin-dependent kinase inhibitor cki-1. Inhibition of seam cell differentiation is regulated by rnt-1 and bro-1, perhaps acting upstream of pop-1, by antagonizing pop-1 repressor function. Required for asymmetrical cell divisions in the lineage derived from a posterior embryonic seam cell, the T blast cell, and for asymmetric expression of zinc finger protein tlp-1. Regulates growth and male tail development. Involved in the oxidative stress response, perhaps downstream of the p38 MAP kinase pathway, and acting as part of a negative feedback loop via a transcriptional target gene, tyrosine-protein phosphatase vhp-1. Positively modulates dopaminergic signaling in a non-cell autonomous manner. May be involved in TGF-beta signaling.
Subcellular Localization:
Nucleus. Note=High level of nuclear localization in interphase seam cells before the symmetric larval stage L2 divisions, but subsequently rnt-1 disappears during mitosis, and largely remains absent when the nuclei reform in telophase.
Sequence:
MTNVFHHVRNFIEQQPAPAKTLEKSSSPNILYTALPKHWRSNKSFQEPFYVVLLTPVPDNTEVSIWAGNDEKPCEEVRNEKAKVHRQVAKFNDLRFVGRSGRGRKFHLTIVIHSAPMMVATVKNVIKVTVDGPRDARIPKPQGSLKRQAEQQTIFPNDIIRTPGPPMPMTMIPPPWFPLPMTQTFPPSFFPLISPGPHPSISAALWKIHSESMKTPIKQKVEQENVSLNTSTCLSSPSIFITPTSDDRKLKRPSSPRSITKSSETSINLIQETPESVESKRRRNVSITSSNSSSPTIWRPF