lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSQTPFNPNSPSVPTTTSLPSTDFSQIPYDVLESIRNRLNQIRQSLTKLADQINNHNRHPQKIKLPSYSYFQNQFQVLITQLMSITNQLYNNEDLLRNTNVYPTPIFPTSAHENMLTTLLRKKVAPEVDEWINGAKLIMENETKNKLDNQQVEIDILKIDQWVQWCLAKIQDLRDEFQFYGFHTVEELDHMETPQGKQEIKEKKDKEFEREQIELKITAGGQKSLHPNQVLKFMCQGQI
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MPSSHLLILSLLLTLLAVVQCGPGADQGWGYDVENGPETWQGKCQNHLKQSPIDIRAPDVDYALLHRMHFMNYDMDGKIELSNTGRTLFAGGFEHWQHRQPMIQGGGLKHRYKLVQFHLHWGQNDAVGSEHALGSLHYPAELHLVHVREGLTLHEALTRPDGLAVVGVFLAKTNDPVANNFSPISERLHDLRHSGNVTELKNFRTKYVLPLDTEAFYRYEGSLTTPDCSEAVIWTVLAEPMAISSHQLHLLRQLHNKELVKSDKNYRPLQPLNGRRIQYRPSKLDRAMICSSAEVASIFSTVFAVYVAMIV
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAVFGSKKFRGAAESNTFAAKYRSALAKHPFALFGLPFILTMVAGSFFLTPATAIRYEKHDRRVKRLSKEEELGIGKAGRRVDMKEEYYRLAAKDLDDWEQKRVKRLPGEHDGKL
The following text describes a protein:
Function:
Xylan acetyltransferase required for 2-O- and 3-O-monoacetylation of xylosyl residues in xylan. Catalyzes the 2-O-acetylation of xylan, followed by nonenzymatic acetyl migration to the O-3 position, resulting in products that are monoacetylated at both O-2 and O-3 positions (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MGLPGRRNPLLSARRAAASLRRSRRLPVYVAAVFFVASVLLMFRDEILYLTTARSPSSSLPTTGGSAGGAGLARKEELVSVNKPVLLGHGGKPEKHHSVTERHRPKVSAKRRPNKKAAKAARKKFMASPSVAAGAEVNVPETCNLSKGKWVFDNATYPLYREQECEYLTAQVTCTRNGRRDDGYQKWRWQPRDCDLPLAFDARLFMERLRGKRLMFVGDSLNRNQWESMVCLVRPALSPGKSYVTWWDGQRVVLHAWEYNATVEFYWAPFLVESNSDDPKAHSIRDRVIKPEAIAAHAGDWVGVDYLVFNTYIWWMNTVNMKVVRPTGKTWEEYDEVGRIEAYRRVLDTWATWVNDNVDPARTSVFFMSVSPLHISPEAWGNPGGVRCAKEDAPVQNWHGPLWLGTDWDMFRAARNASRAAGRVPVTFVDVTAMSELRKDGHTSVHTIRQGRVLTPEQQADPATYADCIHWCLPGVPDVWNLMLYARILSRPPAAAGHVA
The following text describes a protein:
Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway. Regulates the sorting and degradation of N/Notch via an ESCRT-III dependent endolysosomal pathway.
Subcellular Localization:
Cytoplasm. Endosome, multivesicular body. Note=Colocalizes with N/Notch on multivesicular bodies.
Domain:
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Sequence:
MASSAGSAASGSVVPGGGGSAASSCATMALSTAGSGGPPVNHAHAVCVWEFESRGKWLPYSPAVSQHLERAHAKKLTRVMLSDADPSLEQYYVNVRTMTQESEAETAGSGLLTIGVRRMFYAPSSPAGKGTKWEWSGGSADSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQAPYPLVKLTPQQANQLKSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQHPLPTSHQVQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPPKKHSEISTTNLRQILNNLNIFSSSTKHQSNMSTAASASSSSSSASLHHANHLSHAHFSHAKNMLTASMNSHHSRCSEGSLQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVSTYLSHESKESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPVPPPLPLHPRQQQQQQQQQQQLQMQQQQQAQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLWPNAQPCPMCMEELVHSAQNPAISLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGSMSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFLKIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFNMFPDPTYLQRTMQQLVHLGVTD
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Sequence:
MEMDGDPYNLPAQGQGNIIITKYEQGHRAGAAVDLGHEQVDVRKYTNNLGIVHEMELPHVSALEVKQRRKESKRTNKWQKMLADWTKYRSTKKLSQRVYKVIPLAVRGRAWSLLLDIDRIKSQNPGKYKVMKEKGKRSSRIIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYNPEVGYHRDLSRITAILLLCLPEEDAFWALTQLLAGERHSLWYSTAQILPGSRGSYRTRSRCCTSPSQRS
The following text describes a protein:
Function:
Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1. Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogenesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKLSVGIFFGGLFAALGVLLFLVAFGTDYWLLATEIGRCSKAPEDAGTEKATFHHEGFFWRCWFSGNVREHNTSMWKFWYTNQSPSKNCTHAYLSPFPHIRDEHNSTSYDSAVIYRGFWTVLMLLGVITIVMASFLIICAAPFASHILYKAGGGFYILAGVLFSLVVVMYVIWVQAMADLENYTNMKKMDCPDFAVYVRYGWSFMLAPIGVFFALLAGMLFLLVGRAIYLNSD
The following text describes a protein:
Function:
Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MGQAAKVLQLFKTLHRTRQQVFKNDTRALEAVRIKINEEFKSNKNETSPKKIEENWSLGKNSL
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MSDALYIWKLIFSREPSPFISIRVLVGRTSYPKDISRSTIIGNNGGKIPSLLIKRPFRFTRIDVADNEHGFWSGDRDYEEDSSIGSRVLLHSVQLTILKDTKNVLVVTANGSNAKTILFLNLKTQIESLEKNFDTGNKLESYRKIQPAKRQVAIRFQNRRARLKTKQLEMDYQTLKQNYDHLKTNHDNLYEEKKKLRTEIRLNRKFELEHAEVRSKRKIPWFRGFLEENTDFW
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDDLGNPQQIHGIELDNSPNKDESQGKTREIKIGHPSGHHQRKAMNIVEQLLDTVSQEFLLNCAKFIDPSYYDDAIEERFIIRKCGYPICENQLQNVTRQKYHIDTARNKVYDMEKKRRFCSNFCCKASNFFAKQLSTEPLWGRHEIKNKIVLLQHLSSDEQSSAKLPADDHEITLITNNVDLLKINDEAKPDLGSHNSYKLSRQSNNKIKESTSIKEDFERSKIKLTQTDNKRELDATLLMHHDSPSPYSSSKNISPIVSIKETKLKEDLFADDIPSVDVDHAFNHQYQSFHSNSKLKNTFDPCRTLPVMQPTVVVPQKTDPYAKIIHVLQEWSTTETKNFLMPADLNNPNCDPKTETTVHIAKDSWKIDDTRDCRPELSKNGSHDRSISKENLAEPERQETDVYLPLHSSNYQASLRRNIILDRIKKGLREPLSSLNLIYCDIRQDMTDLIRTFRLSRDNISLNHKQWKLLAVILITILSFKNSIIGAHLKSRQENYNQLLRNLDTNEKQILQFSSILHQR
The following text describes a protein:
Function:
Transcriptional regulator probably involved in the response to nitrogen levels. Down-regulates its own expression as well as the expression of the downstream gene, glnD, which encodes the [Protein-PII] uridylyltransferase, a key enzyme in the nitrogen regulation system. Acts by binding to a specific palindromic DNA sequence (5'-TGTNANTNACA-3') in its 5'-untranslated region.
Subcellular Localization:
Cytoplasm.
Sequence:
MMGNKLTLPAELPDEQDLRAVLAYNMRLFRVNKGWSQEELARQCGLDRTYVSAVERKRWNIALSNIEKMAAALGVAAYQLLLPPQERLKLMTNSADTRQMPSESGI
The following text describes a protein:
Function:
Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (By similarity). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (By similarity). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (By similarity); [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8; [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.
Subcellular Localization:
Secreted. Lysosome. Note=Endocytosed by SORT1 and delivred to lysosomes. Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (By similarity). Co-localized with GBA1 in the intracellular trafficking compartments until to lysosome (By similarity).
Sequence:
MWTLVGWTILVAGLVAGIRCPDDQVCPVACCPDSGGASYSCCDPGVDLRTTALSGYLGRPCQSPANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCIQRPDIHLLGAVQCPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHIRCVTALGSHPLTTKLPAQRTNYTGAEGTPVVSPGLLPAALPTSVICPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVCDLRQSRCLSQNKAKTLLTKLPSWTVWDVECDQEVSCPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPEGFRCHTEKDTCEQGLLQVPWAQKTPAQPSRPSQPSPPGPPGPPSPPGPLRSEISCDEVVSCAPGNICCRLASGEWGCCPSSEGYLCMAGERCQVGDRLAPEKMAAHLMSLSQTTDVGCDQHASCPVGQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTCNVKARSCEKAADGAHLAAPLAVGSTGGVMDVACGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRCVHKKSLLHWDSLPRPAAPRPRL
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Note=Mostly localized in the nucleolus, and, to a lower extent, in the cytoplasm.
Sequence:
MTHKKQKKEMSDSEKKTFNEDSKHSILAVDLVRLILERLSFVDFHRARCVSSIWYIASKTVIGVTNPTTPWLILFPKGDVEIKKDSCKLYDPHENKTYIVRDLGFDLVTSRCLASSGSWFLMLDHRTEFHLLNLFTRVRIPLPSLESTRGSDIKIGNAVLWVDEQRKDYLVVWNISSLFGYHKKGDDRWKVFKPLENERCIIAMVFKENKLYVLSVDGNVDVFYFSGNDSPVRCATLPSSPLRKGHKVVVTLSGEVLIIVAKVEPYPRTRLCFFAVYKMDPKSSRWETIKSLAGEALILDLGITVEAKVMKNCIYFSNDQFHRYNENSLWNVSNKSGVFVYHFRSANVVQLVELLTASSRTSKILFKDARCFFPTFTSKWLL
The following text describes a protein:
Function:
Probably transports across the inner membrane the two dehydrated forms of N-acetylneuraminate (Neu5Ac), 2,7-anhydro-N-acetylneuraminate (2,7-AN) and 2-deoxy-2,3-didehydro-N-acetylneuraminate (2,3-EN).
Miscellaneous:
MISCELLANEOUS: Bell et al. show that this transporter allows the growth of E.coli strain BW25113 on 2,7-AN as a sole carbon source. However, Kentache et al. show that it allows the growth of E.coli on 2,7-AN and 2,3-EN, which are produced during the degradation of sialoconjugates by sialidases from other bacteria, provided the repressor NanR has been inactivated.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MATAWYKQVNPPQRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILLVGFDIPGKIYKLSVAK
The following text describes a protein:
Function:
Cytoskeletal linker that plays a central role in the flagellum cell motility. Required for directional cell motility. Plays a role as part of a dynein regulatory system that regulates flagellar beat in response to signals from the central pair apparatus and radial spokes in procyclic cells. Also plays an essential role in the bloodstream form of the trypanosomes as its silencing is lethal for the circulating form.
Miscellaneous:
MISCELLANEOUS: Procyclic parasite mutants lacking trypanin exhibit a motility defect indicative of abnormal dynein regulation, but have an actively beating flagellum and are able to spin and tumble in place. However, bloodstream form mutants lacking trypanin exhibit a severe growth defect and are not viable. They revealed a failure of cytokinesis.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Associated with the cytoskeleton. Localized to the site of attachment of the flagellum to the subpellicular cytoskeleton. Also localized in the flagellum of the bloodstream form trypanosomes.
Sequence:
MPPRTAAERGGRRKSVKAPPPVDPLVELTTLESVHDALAKAERLRNYFQVERDKVNDFWTITKGEVETYRNRLFNAEASIEELERSHQVEMKVYKQRVRHLIYERKKKAQACQDESDRLLREAEDRHLQRMNEIQAKLQQQDQQLRAAAADHEMNVYEKRDSHSYMVTVTKTQSHEKELARLQVSCEAKLKVLRDELELRRRAEIHEIEERKNEHINALIKQHEEKFHEMKTYYNQITTNNLEIIHSLKEEIAQMKQNDEHNETLMYDIDRENQNLVAPLEEAQREVAELQQKRKQNEQNKRGLEVTRVKLRSLREEIRRQREEHQALEERYACVHREREELKGKFESALRQAVMVVEERNEVLQQKLIESHALVEERDVQLEGVLRAMNLEPKTLELIATEVDEWLQRKNQLIKDLHFELKKGEKLYSATLLEMERRCQTANIASLPRSNFE
The following text describes a protein:
Function:
High copy suppressor of a cyclic AMP-dependent protein kinase mutant.
Subcellular Localization:
Nucleus.
Sequence:
MDQPRTHSGPTTASNPAPSSTNSSSAPSATNSKQERSSSSLSKPSSVVPSKDSPDGDAIAKTQAAALKNDMKSGDTSTLDGSSQNIIPNRASMQKYIDQSSDLLSRSSGVITPSMSLNASTNATNNDSSGNSANSSDLKIPIDRDNTIFKTFDTKTGQFLKNDDNEEEIRRNNKVDSIPPKNIYTNINNPSPSPPPSSKQPPSASAPQLPPATEPHKEQAAQQQPPGNASNFLRIFSNKKMRSHSVPTILHSSLRKLSSHNQYYRNQNILLNHPTPSGISKKKFSRNHHQPYLHSNNPLSSNPLSLKRAIFLNQQISGNASTNANNDNINNSTATSMTNQSFLSSSNFDLTLEDRINYIKATPTPVPFPPINLQGLKEIDLQEILKNPQLRHDIIFDPLLQFRPNLDGERGNKKRQLANIYWNDVQNEIYVYSKRPEIFQYNRSRLVPLFDTLRDVLLTIVPQKESPMINNVLDTELNIQELLKGSLIMSNLSGWLADLFKHHCAPMRDPWVDKMSNKFKEAERDSSLTRLIEGLRLVFQILETMKLDIANHQIRILRPALLSNAVEFEKQYFNTLIASKRVNLNTSLLWFDKKFNENVTAGLVRNPSSITIPDVYNICIRSIINLLSCRKMVREYPTPLSFDHARLILLRADIRQIVCILVCRLLFQQLVANDPSMDKATKEYVIHTYSTKRLKNEIISIITDEHGNCRWTKNTMSIAVHLCKVIDDLHREYDNNGSCEQARRPQLPSLDNSKITFAKSWLSKQTQPLSEVYGVLENRVFKSLEDAIFNRSECTIDGRVKQDFVYLYNTNNGNVGSTNTLSTTTDTASVKISPSLMSPSKTSTTTPTGNAIASRGLFAATELEEFENVYRHLYALINLHWSVFGPHYIEMLGDKVNKKGI
The following text describes a protein:
Function:
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
Subcellular Localization:
Periplasm.
Sequence:
MPSLEAPSTRSRLQRMVGSVLLTCSVLLSLSACAAGKASAPQEEEFSYAWLKGYAHTLATESYVSHKGELPKSLQGMSWDDYQQFHFKKKAALWREDDSEFRAELFHLGLYFDTPVHIYQLENGKAKRIEYSPSMFDYGKSKVKGSQLPKDLGFAGFRMQFNTDWQRDVVAFLGASYFRAVGQEMQYGLSARGLAVDTALPKPEEFPMFTRFWLEKPQPGSNIATVYALLDSPSVTGAYRFDIEPGERLKMKVDAAIYPRKAIERLGVAPLTSMFMVGENDRRTGYDWRQEIHDSDGLAMHTGNGEWIWRPLGNPSNLRFNAYSDENPKGFGLLQRDRNFDHYQDDGVFYEKRPSLWIEPTGNWGKGSVQLVEIPTLDETFDNIVAFWNPAEPIQPGQELLYSYNMYWGGIPPEQSPRARVVDTFTGIGGVVGQKRKYYSKRFVIDFAGGSLPMLGKDAQVKAVISTSQGRVEIESARPQHAINGYRAMFDIVPPEDSVEPINLRVYLEVDGQPLTETWMYQWTPPPMNERELHNAGHLQ
The following text describes a protein:
Function:
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. Together with PAT1, the LSM1-LSM7 complex binds to osmotic stress-activated mRNAs to attenuate the osmotic stress response, probably by limiting ribosome access to the mRNA and consequently translation. Component of the nuclear LSM2-LSM8 complex, which is involved in spliceosome assembly. The LSM2-LSM8 complex plays a role in the biogenesis of the spliceosomal U4/U6-U5 tri-snRNP complex by accelerating PRP24-mediated annealing of U4/U6 di-snRNA. The LSM2-LSM8 complex binds U6 snRNA terminating with a non-cyclic 3' phosphate group. LSM2-LSM8 is probably also involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM2-LSM8 could be involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA, although involvement may be indirect. In a complex that probably contains LSM2-LSM7, but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA; the complex also associates with snoRNA SNR5.
Miscellaneous:
MISCELLANEOUS: Present with 7060 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm.
Sequence:
METPLDLLKLNLDERVYIKLRGARTLVGTLQAFDSHCNIVLSDAVETIYQLNNEELSESERRCEMVFIRGDTVTLISTPSEDDDGAVEI
The following text describes a protein:
Function:
Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant.
Subcellular Localization:
Cell membrane.
Sequence:
MTVLRPGHGPAAPVRSAARHRLGTRLDALDPRVRRDVVRLLTLLALLPLLLLLARGAVRLPHAFDPLALYGLAVLAGTVCLLHLAYSRYDDPAVRPLRSRPRHAEAFPALPARPRVSFLLAVRNERAHIEACVRSMAGVDYPDVQLVVVDDASDDGTPDVLERLAAELPLTLIRLEENLGKKGALVRACAVADGDVLLFTDSDCVVAPDAVRHCVTALVRHPELGAVGGHCRALNTDAGLLARVQDIWYEGQFRISKAAEAAFGSVTCVSGPLAAFRREAVWNYLPAWAEDRFLGAPFRFATDRQLTGYVLGQAWHGRALKDRHADSPFVRDHDYPELRWEVGYTRAARVWTRVPSRPGSFLRQQIRWKKSFIRNLFFTGRFMWRRGPAAAALYYGHALWVIAAPVLVVRHLLWAPLHLAGPLTLLYLGGVVLKGCVWGLAYRLDHPGDRAWRCRPLMSLLSCCVLAWLLPYALLTLRRGVWSRSAA
The following text describes a protein:
Function:
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
Sequence:
MTDASALDFDVVPSTDQSFENALANARDGRRLTVADGIELITTGTDTDGIDPRRKELVLEAADRRRADVVGDDVTFVANLNNNVTTACNTGCLFCNFKDTAHRFETEHEAAHGGFTKTPAESKATVADAIQRGVSEVTSVSGLHPAFGLNEAHRDALDPDDPDHNYKPPEAYDTDPTTYAAQIAAMSEAGAHVHSITPEEAHHAQRGVSWGYDEVYETLADAGLDTVPGTAAEILVDEVRDVICPGKMTTDEWVAAMEAAADAGLGTTATIMYGHVENAAHRIHHLDVIRALQDRTHNITEFVPLSFIHEQTPLYERGVVDGGASDAEDELMIAVSRLFLDNIDHIQSSWVKFGDAKGLALLNCGADDFMGTILSEEITKRAGGQHGEFRSVADYAEMISAIGRTPVERSTDYTTRHVINPDADTIGPHVGPNADGTPLVSERAGTPPHSAGD
The following text describes a protein:
Function:
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MEVTWIRWGLLLCAGVFASSEHSRVRRITYVVRPGQSGSSDTGVSGGVGQLSSAVPLGGHPRQQRTFNVALNTRYSSSSSSSSRSSSSSSSSSSSSSSSRSRSSTTSTQERTRRMSKPSAPSVQVLRQPQPPQEQPLRLGPGMQHHPKPVGHPSAAQFSKPGRHAVRSKLQQETHSLSSSSSLQVHQKQQLQGVNVCGGQCCQGWSKAPGSQRCTKPNCIPQCQNGGMCLRPQLCVCKPGTKGKACENTVVQDTTSISSSGSKGPGPSSWIIPEPAVQHPTSQKVEIAQRVSPVAQMTLTLKPKTAVGISQQMHSQVTPLSSQNLMIHHGQMQEYVLKPKYFPAQKMISGEQSTEGSLPLRMGQDHVVSPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNNCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNYTGKLCQIPVHGANAPKLYQHSQQSSKSLGTHVVHSTHTLPLTMTGQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGSTGQKVKESQPGQSQISYQGVPIQKTQTIHSTYSHQQLIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFHKCQKCPKKPAYHGYSQIMECPQGYKRVNATFCQDINECQMQGACPNGECLNTLGSYRCTCKLGFVPDPTLSTCIPDNPVISEEKGPCYRLVNSGRQCMHPLSVQLSKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHIGKGPVYIKPKNIQPIAKSTHPPPLPAKEEPVEALTFSQEKGRQVAVQEVATAAPEKELVDQEKTKLEPGQPQLSPGVSTINIHPQYPVVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICNEGYKFSELQRKCVDIDECTQIHHLCSQGRCENTEGSFLCICQAGYMANPEGTDCIDVDECLRPETCGDGHCINTVGAFKCEYCDSGYLMNRRGQCEDIDECLAESTCPDEQCINTPGSYQCVPCTEGFKGWNGQCLDINECLDPKVCSNGSCSNLEGSYTCTCHRGYNPTPDRKQCKDVDECQYGNLCTHGQCKNTEGSFKCTCEKGYHLSAAKDQCEDIDECQHRHLCTNGQCRNTEGSFRCICDQGYRASALGDHCEDINECLEDSSVCQGGDCMNTEGSYECTCPSGFQLTRNKECQDINECEQRELCGPHGECLNTDGSFHCICEQGFSISANGQMCEDIDECVNNTICDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECEMLSGVCGEAFCENVEGSFLCVCSDESQEYNPMTGQCRSRSSTEVDVDQPEEEKEEKKECYYNLNDANFCDNVLTSNVTKQECCCTLGAGWGDNCEIFPCPVFGTAEFTEMCPEGKGFIPTGHSSYDVTGQNYKDANECQLFGQEICKHGFCLNTQPGYECYCKQGTYYDPVKLQCFDMDECQDPNSCIDGQCINTEGSYNCFCTHPMVLDTTEKRCIRPTDSNEQTEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGPRRPYGQDALVDFNAHYSPETDPYFVQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMTKMTCVDVNECDELNNRMSLCKNAKCINTEGSYKCLCLPGYVPSDKPNYCTPLNPEKDSDLE
The following text describes a protein:
Function:
Phosphatase which may play a role in the egg laying muscles.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with unc-89 at M line.
Sequence:
MTYAESTRSAVVYSSIVPPPRTPVGPPMLKDGVRKGSASQPLQPKNGANSLDYWSKSEDEKSGITCYYSRHNIQFPPPQRKMKPVKPNPVGRSTINGFTPSTSSPQNGLRYPPFPQNTPESVMSPPVGIYRNIPAMPRAKLTKDEKNGGKMNRDGGGENPKNVVWGGTSRKDDDTASTPLNSFSANASIEKKRSTARRKPRWARCFQTLFCCVTPPREIEKIQSSQRTNSTNNNHQNGRPSTPTNTGPPIQLITQVHRDGTVTGLPTTGQACQQNGSGDGVTPYDKIANDSVGTINEKPLLPPLLPQDSNKKCLVIDLDETLVHSSFKPVKNPDFVIPVEIDGVEHQVYVLKRPYVDEFLAKVGEHFECILFTASLAKYADPVADLLDKKRVFRGRLFREACVFHKGNYVKDLSRLGRNLNQTLIIDNSPASYAFHPENAVPVTTWFDDPSDTELLDILPSLEHLNGFSSIYDLYRPEEGPQSELLNHCSC
The following text describes a protein:
Function:
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence. Involved in the negative regulation of floral organ abscission by binding to the typical DOF 5'-AAAG-3' sequences in the promoter of ADPG2/PGAZAT, and by down-regulating its expression. ADPG2/PGAZAT is an abscission-related and cell wall hydrolyzing polygalacturonase. May act through the interaction with ZFP2, an abscission-related transcription factor.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing DOF4.7 fail in the abscission of floral organs (sepals, petals and stamens) after anthesis.
Subcellular Localization:
Nucleus.
Sequence:
MMTSSHQSNTTGFKPRRIKTTAKPPRQINNKEPSPATQPVLKCPRCDSVNTKFCYYNNYSLSQPRHYCKNCRRYWTRGGALRNVPIGGSTRNKNKPCSLQVISSPPLFSNGTSSASRELVRNHPSTAMMMMSSGGFSGYMFPLDPNFNLASSSIESLSSFNQDLHQKLQQQRLVTSMFLQDSLPVNEKTVMFQNVELIPPSTVTTDWVFDRFATGGGATSGNHEDNDDGEGNLGNWFHNANNNALL
The following text describes a protein:
Function:
Acts as a positive activator of the GCN2 protein kinase activity in response to in response to low amino acid, carbon, or purine availability. Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes; during this process, GCN20 helps GCN1 to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity. Participates in gene-specific mRNA translation activation, such as the transcriptional activator GCN4, by promoting the GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) on 'Ser-52', and hence allowing GCN4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
Miscellaneous:
MISCELLANEOUS: Present with 14600 molecules/cell in log phase SD medium.
Sequence:
MASIGSQVRKAASSIDPIVTDYAVGYFNHLSGITFDAVQSKQVDLSTEVQFVSDLLIDAGASKAKVKELSESILKQLTTQLKENEAKLELTGDTSKRLLDINVLKSHNSKSDINVSLSMLGVNGDIEHTGRKMETRVDLKKLAKAEQKIAKKVAKRNNKFVKYEASKLINDQKEEDYDSFFLQINPLEFGSSAGKSKDIHIDTFDLYVGDGQRILSNAQLTLSFGHRYGLVGQNGIGKSTLLRALSRRELNVPKHVSILHVEQELRGDDTKALQSVLDADVWRKQLLSEEAKINERLKEMDVLRQEFEEDSLEVKKLDNEREDLDNHLIQISDKLVDMESDKAEARAASILYGLGFSTEAQQQPTNSFSGGWRMRLSLARALFCQPDLLLLDEPSNMLDVPSIAYLAEYLKTYPNTVLTVSHDRAFLNEVATDIIYQHNERLDYYRGQDFDTFYTTKEERRKNAQREYDNQMVYRKHLQEFIDKYRYNAAKSQEAQSRIKKLEKLPVLEPPEQDKTIDFKFPECDKLSPPIIQLQDVSFGYDENNLLLKDVNLDVQMDSRIALVGANGCGKTTLLKIMMEQLRPLKGFVSRNPRLRIGYFTQHHVDSMDLTTSAVDWMSKSFPGKTDEEYRRHLGSFGITGTLGLQKMQLLSGGQKSRVAFAALCLNNPHILVLDEPSNHLDTTGLDALVEALKNFNGGVLMVSHDISVIDSVCKEIWVSEQGTVKRFEGTIYDYRDYILQSADAAGVVKKH
The following text describes a protein:
Function:
Required for cell viability in cells lacking mitochondrial DNA.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPPLPQNYAQQQPSNWDKFKMGLMMGTTVGVCTGILFGGFAIATQGPGPDGVVRTLGKYIAGSAGTFGLFMSIGSIIRSDSESSPMSHPNLNLQQQARLEMWKLRAKYGIRKD