lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MANCRLFPLLILLLLSFQSLLTAHEDPSYKDIQVGVILDMESGAGKVIYHCITMAISDFYAANPDCKTRIVFMTSDTKGEPLHAVSAALDLLENTQVQAIIGPESTAQARFLEVLGDKANIPILSLSTTPFSNRNPNLLGIAQDETSQFKGIAAMVELFKAKNVIVICEDTANGREMATYMAREFQEKNIHVTYTSLISTSDSNQQVREELHKLQTMQDTVFIVHTPPSLASNLFSMAKELGMMGEGYMWIVTSKTMDLLGSMDAEAIESMQGAVGFRSYFPSSKELHNFLLKWRKEHDALDPFMEVDSNGIWAYDAVYALAMAVERVQTTSLLDEMLRFKFHGLGGEFKFMNGRSISKPMEVVNVIGKGDRSIGFWMMDTGEFVKEIEKLNSSSNQGLESIMWPGGTTTLNPKRRMLQTNGNKKLRILFPGSSRFQNIAQISVDPRTNLSVVSGFCGDVFNAAFNSLDYGVGVEVVPFSSKDGITYNDVIQKIYLKEFDAAIGDFTITANRSLYVDFTLPFTDLGVGIISRNAKDSMWIFLDPLSANLWITTAFFFIFLGLVIWFIEHRTNEEFQGSAPQQLGTTLWFAFSTLVYAHREKLQSNLSRFVVTVWVFIVLVLTSSYTATLSSLLTVQQIGMKEMSIGFQGLSPVGVVYNKLNVVEAWSEKLYAPEDYAKALTTGRFDAIVAEILYMKTFLAMYSGADFSLIATAPTTNGFGFAFQKGSPLAREMSTQIAKMCEDGTLKALEDKWLKRESALISKDFSSPTPKLLNLYGLRGLFLISGVSMVSALLVSIICLVREKWRMKDKMKIWRCVLHRSSEIHAHESDVESTV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.
Sequence:
MNIALEVRPLLKVCKIKLTVRVNKDEAAPRLQVECTASSLTATLEKPNREVQESTELILPTHLKFKPDTRSPLKNTRIPRSDDPVQGTSEYREVTFSIHVEEDEAGSCSLEPLESSDGPVRTTDIAKPVAGCPYAILCRKCKNELVPKDTVFRRVLPLPSADWKEMAAEWFCHKHESEKELPTKLAPKPDEMFTSVSYLHLHGSLVGGVVDGGDAGDWIRCGKCDSVVAKREEEGVVAVLQMRVDIVSWKEDEPKLVLRTDAASLMRGLMKEQMALSMSCRILLETEETSLLLWLMETGLEMFRATNLASGPHHVRFTRVTKTLAVKGDDKGAEEAN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAAALGHQVQAPQKNSTWGQKAALQVEVTTDSEAFRQQFRQFCYQEVGGPHEAFSTLWELCCRWLRPKTNSKEQILEMLVLEQFLTILPGEIQVQVREHRPENGEEAVALVEDLQKETERPEEQFSVSVQNPEVLVEKIVPVGAAQESVSYQLKQEENQQDEDPSKDTSWSPHEGSQDQADYKQDPQLRPETTRLLAGDTPQVSAFSQERRMRNQEMEAVILTTGFQEPVTCEDVTVPLSQEEWRCLNSAQRVLYKGIAQEKFRNVDSVGLPKSLLISGMNHGKDICIPDLQGSKETEILSSSHTNENRVQADEKQANREGKNWGDQRQQELADEKISGFKRKNEIKKENLKWEFSEEQLSRTVQGKFNRQIFQYPVLKEACETVSKLRKQLISFPREKQGKPAFQERDLMKQLDQQKLFVGEKHHKQLACGNSFSQNFHKSAPELEKTTKCQQCGKSFSRGSYLVRHRRIHTGEKPHKCNECGKSFSERSNLTAHLRTHTGERPYKCGECGKSFNQSSSLIVHQRTHTGEKPYQCNECGKRFNNSSQFSAHRRAHTGESPYKCRECGKSFNNSSHFNAHKRTHTGEKPYECSQCGRSFGKSSALTRHQGVHMREKFLIQSRINVLEGDIS
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDNDDDFMCDDDEDYGLEYSEDSNSEPDVDLENQYYNSKALKEEEPKAALASFQKVLDLENGEKGEWGFKALKQMIKINFRLCNYDEMMVRYKQLLTYIKSAVTRNHSEKSINSILDYISTSKNMALLQNFYETTLDALRDAKNDRLWFKTNTKLGKLYFDRSDFTKLQKILKQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTVQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVNSYQNNDINEFETILRQHRSNIMADQFIREHIEDLLRNIRTQVLIKLIRPYKNIAIPFIANALNIEPAEVESLLVSCILDDTIKGRIDQVNQVLQLDKINSSASRYNALEKWSNQIQSLQFAVVQKMA
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme responsible for the elongation of palmitate (hexadecanoate, 16:0), also involved in polyunsaturated fatty acid (PUFA) biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAAAQTSPAATLVDVLTKPWSLDQTDSYMSTFVPLSYKIMIGYLVTIYFGQKLMAHRKPFDLQNTLALWNFGFSLFSGIAAYKLIPELFGVFMKDGFVASYCQNENYYTDASTGFWGWAFVMSKAPELGDTMFLVLRKKPVIFMHWYHHALTFVYAVVTYSEHQAWARWSLALNLAVHTVMYFYFAVRALNIQTPRPVAKFITTIQIVQFVISCYIFGHLVFIKSADSVPGCAVSWNVLSIGGLMYISYLFLFAKFFYKAYIQKRSPTKTSKQE
The following text describes a protein:
Function:
DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.
Sequence:
MIESNDYEQERLKNIRENERLMKELGVMGGSSTIGGPSSKRTTPTKPKKQATPKKKPDTTPTRIMPSRSSARLAGHEADSETLKRKYEEEAEEARKVAEAAKRARHQPFDLSGMTGGELEEEAIMALESTLQGLANNTSSAAELVDTKDENKRRSANKPDPQFSTERRELEDILNKMTLKSAAKVTPKRIYSMAYHPSTDKDLVFVGDKEGSIGVWDAAPVAFASNRNGVKTADDQDEDAEERFPEGKAWTLQVHARSPVTCIKFDPVNHNSVLSSSYDSTVRKLDLATAKSEEIWAGEEDVLLSIFDVLSPSTHPSVYMDTPNPSLDERSMWIADHRGGLLHIDLRERTRRGNNTRRWQVCEKKIGAMSVNRLAPHCIATASLDQHIRLFDVRALASVVKQTADAPYNYKGVDADDLESAQTKAQFASSKARQACTSVDFSPRGDQLVGVSYDDVVKVWSMEPGSLFSEHGLKNRIATAKSNKPKGAVKKQVPDSASDTGPGLLSWLSRATPLGTKKDVAEAIKQEQDAPSPSLSKRPDDVLANPTRIPHNNQTGKWLTLFRAKWNQNALLEPHFTIGSMSRRAEVYAADGTLLRSLWDENLVTAVPAVTCMHPVLPARLVTGNASGRCTFWSPDP
The following text describes a protein:
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Sequence:
MESSAERRLKAIQSHLVPATDDVSRSLIRSNPTAGEFLLGQGFSVVLPEKLQTGKWNVYRSARSPLKLVTRFPDHPEIGTLHDNFEHAIQTFQDYKYLGSRIRVDGTVGDYKWMTYGEAGTARTAIGSGLHYYGLQPGARVGLYFINRPEWMIVDHACSAYSYTSIPLYDTLGPDAVKYIVNHADVQAIFCVPTTLNTLLTFLSEIPSVRLIVVVGGIDEHLPSLPSTTGMKLLSYTRLLSQGRSSMQPFCPPRPEDIATICYTSGTTGTPKGVVLSHANLIASVAGMTLAIKFYPSDIYISYLPLAHIYERANQITSVYSGVAVGFYQGDNLKLMDDLVTLRPTIFSSVPRLFNRIYAGITNAVQTSGVLKQRLFNAAYNSKKQAVMNGRKPSPMWDRLVFNKIKDKLGGRVRLMTSGASPLSPDVLEFLRVCFGCQVMEGYGMTETSCVISSMDETDNLIGHVGSPNTACEIKLVDVPEMSYTSEDQPHPRGEICVRGPIVFQGYYKDEVQTYIPYSLIFHFLFCHCHELLQDNLPDLVVNRKEVVDDDGWLHTGDIGLWLPGGRLKIIDRKKNIFKLAQGEYIAPEKIENVYAKCKFIAQCFVYGDSFNSSLVAIVCVEPDVLKEWASSEGIKYEDLGQLCNDPRARAAVLAEMDAVGREAQLRGFEFAKAVTLVVEPFTIENGLLTPTFKVKRPQAKAYFAKAISDMYNELSTSDPVSQKSL
The following text describes a protein:
Function:
May form an ATP-driven capsule polysaccharide export apparatus, in association with the CtrC and CtrD proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSEQLPVAVATETKAERKKPKKKSWIKKLSPLFWVTVIIPTVISLVYFGFFASDRFTSQSSFVVRSPKSQSSLNGLGAILQGTGFARAQDDIYTVGEYMRSRSSLDELRKILPVREFYETKGDAFSRFNGFGFRGEEEAFYQYYKNQVMINFDTVSGISTLNVTSFDALESKKINEALLKQGEALINQLNDRARADTVRYAEEVVKTAAERVKEASQNLTDYRIANGVFDLKAQSEVQMGLVSKLQDELIVIQTQLDQVKAVTPENPQIPGLQAREQSLRKEIDQQLRAISGGGHSSLSNQAAEYQRVYLENQLAEQQLAAAMTSLESAKVEADRQQLYLEVISQPSLPDLAHEPKRLYNIVATLIIGLMVYGILSLLTASIREHKN
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MDKKDSFTTAHSTPPYLNTSISWGLPTESNVQSYDVTESLSLKVHARSKHVLNPTKIGFQDKDSSSTQSTDQSSTEVATSADDDDDDDNPSRQISFSAQPDVCRGFEETQRKVIPNNIRSGSSHTTRISDIHFAPGKANFFFPCADPRFGGYLPHATVWHPKMVSRVPLPLELIDNEPVFVNAKQFHAIMRRREQRAKLETQNKLIKARKPYLHESRHVHALNRPRGSGGRFLNTKKLQESKEPKHDTSIQQKDAKGNMSGFVAHQLQTSNDRGCSTTSGSDITSVTDGIKANPTMYIHGQSNDMHGGGNRGGNTHHFSVHI
The following text describes a protein:
Function:
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
Subcellular Localization:
Cytoplasm.
Sequence:
MESYIQNLFAERIGGKSFGKEDVIYKFEKIKRAKQAAKLKYPDMELIDMGVGEPDEMADESVVEVLCEEAKKHVNRGYSDNGVQALKDEIPIYLEKIFGVKDLDPVNEVVHSIGSKPALAYITSVFINPGDVTLMTVPGYPVTATHTKWYGGSVETLPLLEKNNFLPELDAISKEVRENAKILYLNYPNNPTGAQATKKFYKEAVDFAFENDLIVIQDAAYAALTYGDKPLSFLSVKDAKEVGVEIHSFSKAYNMTGWRLAFVAGNELIVRGFAAVKDNYDSGQFIPIQKAGIHCLRHPEITEKTRAKYERRLSKMVKILKEAGFNAKMPGGTFYLYVKAPIGTKDGAKFANAEEFSQFMIKEKLISTVPWDDAGNFVRMAACFEAFKDGEISIEEEDRILNEVKRRLTEVEFVFE
The following text describes a protein:
Function:
Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as a zinc importer that helps to alleviate ER stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKASHICSYLLSIAPLVVSHGVHHNRDHGHEANHESKQSFLILKQESIFYSLVCFLQNHLFVLGPRYNAIVAILIIQLMPCLFVLFVPGLRKNDRASLTLSLLVSFSLGTLLGDILLHVIPESLSGVTDVTMVGGAIFLGFISFLTLDKTMRILSGTSNDDGSIHSHSHSHTPQQTAEKKAGFNMSAYLNVISGIAHHITDGIALATSFYSSTQVGIMTSIAVTFHEIPHELGDFAILLSSGFTFPQAIRAQAVTAFGAVVGTSIGCWMNEIGNNSHKATSSSANASELMLPFTAGGLIYIATTSVVPQILHSSAPDSKLREFKKWALQLVFIFVGFAVMALMDEH
The following text describes a protein:
Function:
Part of a lipoate-protein ligase complex that catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Can also use octanoate as substrate.
Miscellaneous:
MISCELLANEOUS: In contrast to E.coli, where the lipoate-protein ligase is encoded by a single gene product (LplA) with a large N-terminal domain and a small C-terminal domain, the same activity in T.acidophilum is dependent on two separate proteins, corresponding to the two domains of E.coli LplA, respectively.
Sequence:
MVLNYTMHMMYSKNWKAKKGLIRVTLDLDGNRIKDIHISGDFFMFPEDSINRLEDMLRGSSIEKINDIIRDFYNQGVITPGVEPEDFIQALRVI
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass membrane protein.
Sequence:
MKQRGRLRDGPFSIDVGSGVITLASPLEKTKFRYHLNISAIDNGACCPGTTSRKSHGQLIIEVKDVKNHAPKFVDCASYNPVIMENENVGTFVVRVKAVDLDAGQNGKVSYSIVKSNDQSSDKFEINSSTGEIRTSEVFDREAQLGVTDYGITVKAEDEGSQSLAGFCSFRVKIGDKNDNPPVFSLSTYLTSVEEKFPVGKRVKQVYATDRDIGDNGKIEYYMKSDPSGFFAINQFNGWVSIAKPMSGVSFLSKLTFVKVIIAIKLIYLTEHCNKSLTSLVFTPNNPLQRDMVKIVIEARDKGVPPQSSISHMEIKITQKSNAYPSWDKDYSQIPLTVSENAPENTIITRLRAHSSIPDSTVNYIIQSADVPEKNGEPRSFYHLVDEKNNEMVLLTYRALDFEAIPHYFITVKAANRATNSLHIDTRLLINLIDENDEIPQFVGLNENGLFSATVAENMKPGTDVITVSACDKDHNPFYSKISYRLKKEGTDYDKFTIDKDTGVIRSRATFDREVKQDYYLEVIAEDGAPSQRTNHYPPGTPNQGIAGVQIRVTDTNDNTPYFKNENYTTRVPENTDPGTVITTVTAEDNDEDHRLFYSIVDGNLGNAFEVTPDNGEIKVRGQLDYENGPREYRLMYRVFDEKFTNFTLVIVQVLDVNDNPPKFDNSIYNVTDINEEEPGISKNNEKYLLTVRATDPDVDRKSSIRYSLTGQFADDGTFVINESSGTISLTRPLDRDAGKGRPVWNFNVLAHDESRDDQPSLTGYAEVRVMPRDINDNAPVFDRNRLIGRVPEHSKAGVTVLTVITTDVDNGNNGSVTYSLKQVPMKGQQPLFTINTQMGLISTVIPNALDREVQAEYQVLVQARDRGIPPLMSSATVTILVDDVNDHRPRFSHLLYKAVLSESEPEGHHVLTVSATDKDSGNNAKLTYSLKEKDRSHFYIDTIETTNSGVIKVFKPLDYDTMEKPYFNLTVHVRDSNPNHNDTAFVEITITDANDNPPVFNPNLEKATLFENATVGTTLKKFTAIDIDTGINAEFSYSIDRSTDMEKQFAVDANGLVTVSKPLDMEVMPAHRIQIHAIDKGNPPQTGRGTLMISLLDVNDNPPEFAAIYQPVVYENKPAEQMVIMVSAVDRDSAANGAPFELWLPCGGACPCQANPTCADFGFTFIPGGGLNGNGAGRIQTLRSFDRELQKEYEIPIVMRDSGQPSVSGTSTLTVTIGDVNDNEHFPGHKEVLVNKYVGWKGEFDNYPLGNVFAEDEDDWDLENKTFQLVHHHYHDKLFRVDKNTGQLYTKSPLKETTYNLKVRVHDLVWNKEVVSTVRIEVHSFADDAVQNMASLRIQGITAEKFISKPEKSKKISNVFAQHEHHSRMELFAMLLASKLDGKEYRASNVEILSVTNHATMLNVIDVWFAVHGSLYLKPSKLNGLIHVYKQEFESVLEGSILMSPINECMIEKCLDVTDGCRTLVTISEHEPLIINTNSSSFVGVIAQSKAECSCSSAASFLESLGRECQPSSCFNGGTCVQKYSTLECLCPPDFNGPRCQQTHISFSGSGYAWFQPFEACRHNHISFQFATTRATGLILYYGPITYTKNNPFLALELRNGYPLLRMDDGKGEVVLSFVEVDLHIVNKMNKLNDGAWHRVDIIIQNQFVRLIVDRCERGPSIFESESESSSIVLTNSCESMANLSGEDRGMMHINGPLSLGGSHPDSSIPEHITDDAFEGCIKHLVINNQLYDLHVGLEGQGDSFEDGCRKEEAICHGLSSSNPNSSSKSSDKLARQSGKNRCGSEGECLAGIVPSSNVQCVCKPGWRGFGCSIPTTVLDFGQKGFVELDFKDDMYADMDRKNGFESDLKVMVRTRQTSALLFKSYNTQKSEFIALEIIDSRLTYRFNIGSEESKVSLSQLNISDGEWHSIAVERRGIWVEMIVDRGEGIYCNRSFPMIDKHHVAFKVSQRSIVLGGDVKFPSFGSDPLVSRDFNDGCLTDVRYNGMWLPMTPQENDESECAEVMSRSQNIEAGCSSEACNQIDICQDGLVCVDLWRRAECRCPIGSRPVTIHHQQPLFNEQPFHHQPPFQHHIHHQQEQQLQQQQNLQYSQHLKRQSLDEQLACEPINECLESTPCLHGQCQDTPEGFYCLCNSGYTGPICAEAVTASFVAMTPEALLAIVLSFTVVTVIVFVAILVMRRRPHTSYSDVDLCDDVRDNIIRHDEEGIGEEDQQKYDISKLKKPVQPVGNGLAKPNNNINNTNKNSKNNSTNHNNINKNNANNKLKVANKHLTSVNNIDLLNNHKVMYEMQTVPILVNDKKPPKSSLVVKGKKELYSSSSNRTTPQSRLPLPSSSFPSSSSSSPRVHSDDMLVVLKKKLKKIEADPVAPPFETVREYAFEGCGSYAGSLSSLASNCDDDDDVIVGNDENHMTAGRAVDRRFIISQLTNQRPAFKKLADLYGSNITVYFSDNDANANEDAFNNASHPLHAICGNVFEIEQGDCNRAVRHLDHFTNTQFVKDV
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
FSDPASAHGTKSTTEIIRSIAVFQACRIPFLVKNAERLLDLSSKVLGNTITNTLMKYTFFRHFCAGEDSVDMKPVIDKLQANNIGPILDYAAESEGSDDGDDVPAIVFEGKRCYILYNMHLYLQIWYQQQYSFLSPTGISTQPLFNQPARIYDYTTEKECDRHVEIFKNCIRSVRDVSPHGFAALKVTALGNPELLERMSTIIVEVKKFFALMDEKKSGFITREEFLTCYDRHFHREDQDALSEVLDFLDADNTGMIDYISFAKMLTPYTLPSFTLKCKDVGPLAMATPSVDEIALMVKMSERLNTLAEEAAACGTKLLIDAEHAKYQPAIDSLVLELQQKFNAKDVTDRPVIFNTYQCYLKDMPERMITDLKRSERYNFHFAAKLVRGAYMVHERERAKKLGYDSPIHDTAQDTHRCYNEVVELLLRHRMQHGPGVEMMIATHNKESIEKAVSLMNEIGLYPNDATVHFAQLYGMSDNLTFTLGNSGYNAFKYLPYGEVQEVLPYLLRRAQENGDMLGNAGTEVSLLGRELKKRLSFA
The following text describes a protein:
Function:
Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway.
Sequence:
MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGETAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLFSGDVSCVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQA
The following text describes a protein:
Function:
Probable transcription regulator that functions in the development of the carpel margin meristem similarly to SEUSS (SEU). In association with SEU, supports organ development from meristematic regions by facilitating auxin response and thus organ initiation, and by sustaining meristematic potential through the maintenance of PHABULOSA expression. DNA-binding adapter subunit of the SEU-SLK2 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes.
Subcellular Localization:
Nucleus.
Sequence:
MASSTSGIFFQGDDESQSFINSHLTSSYGNSSNSAPGCGGPTGGYHNLSMVSGDMHNPVMMSVSTPGPSAGASSLVTDANSGLSGGGPHLQRSASINNESYMRLPASPMSFSSNNISISGSSVVDGSTVVQRHDPSVQLGGSSATSLPTSQTNQIPLSMARRASESFFQDPNNLTQARKKPRLDSKQDDALQQQILRQWLQRQDILQQQQQQQQQGQNPQFQILLQQQKLRQQQQYLQSLPPLQRVQLQQQQQVQQQQQLQQQHQQQQQQLQQQGMQMQLTGGPRPYENSVCARRLMQYLYHQRQRPSESSIVYWRKFVTEYFSPRAKKRWCLSHYDNVGHSALGVSPQAATDEWQCDLCGSKSGRGFEATFDVLPRLNEIKFASGVLDELLYLGVPSERRYGSGIMVLEYGKAVQESVYEHIRVVREGHLRIIFSQELKILSWEFCTRRHEELLPRRLVAPQVNQLLQVAEKCQSTIDQSGSDGIHQQDLQANSNMVMAAGRQLAKSLESHSLNDLGFSKRYVRCLQISEVVSSMKDMIDFCRDQKVGPIEALKSYPYRMKAGKPQMQEMEQLAAARGLPPDRNSLNKLMALRNSGINIPMNNMSGQGSLPGSAQAAAFALTNYQSMLMKQNHLNSDLNNTTIQQEPSRNRSASPSYQGTSPLLPGFVHSPSISGVSSHLSPQRQMPSSSYNGSTQQYHQQPPSCSSGNQTLEQQMIHQIWQQMANSNGGSGQQQQSLSGQNMMNCNTNMGRNRTDYVPAAAETPSTSNRFRGIKGLDQSQNLEGIISNTSLNFGNNGVFSNEVDESMGGYSWKS
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
RRDLGDHGDDLRWRFPPPENNSRHPVTTSQQSHVASQNLHLIPIYQKPNQQDYHVENPSLQNPTTQDQLSGHLHYSNYPYDKSLAMEPSTCRCRTPESGLSRPSQFAAPRPPLSQYLPYPIPLNQAQYSFINSLPTSFPLENHETIDLQSGFDLQSGFEGLNIDGLGLPRPNNLTVQRNLVAATNRYATTNNASPSYSNLSHGFLSDHHHLGSSTNASSRYNNFYARARHHHHRTSYSSIEELRGRIILVAKDEQGCRFLQKKVDERNPIDIEMILSEVIDDLHELMRHQSANHLIQKLIGVLNEEQMTKLILSVVSSQQRLLRICDDLSGSRVMQKLLDAGEYPTRQQLTQEQQSLLVSALKNITVSLSKSPHGNHVIKRCLQKFPPDYTKDLLEEIAENCLDLATDRSGCCLLQYCIPLAQEEQKARLIADVVANAYVLSEHSYGNYVVQYILGLKIPQVTADVVAQLAGRYFALSLGKCSSNVVQKCLLESGEEQSTGIINEIIRHPEIVQLILDPYGNYVIQTAWDVSQGRRIRQTLYDLVVDNSPFLQSHMYGKNVLAKVRGNKNRFHNRVAMW
The following text describes a protein:
Function:
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. May play a role in the regulation of cell proliferation (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MFLKFKNIFFIVLTLSIVFNGLIVNSKNIHINNKNNNNNNNNKDLSSSESGSSSDINPYISQYNSERETLVNQENQIKLGSNTPFNSKEQQANTIFLNILQNEELSFSNNDPSGVNFFIEKQIIENESTIFKIIQNMPKGSALHVHQDSSATYDYLISVGSYLPNCYIYLTYDVNDANNGTFHFYDSQPTDSNWKLLSTIREGVSNVESFDQQLLDSLTLIGQDYGDYVSLWRKFDGIFGRVNGLVTYLPIATGYMEHLFQQMIQDGVQHIEVRKCFGDFYDLTGKIYDDYWFVQTMEELVLTTRQKYNMSEFALKIIGCNGRHNNQSVVYDAMVMSLDLRNKYPSTFVGYDLVGPEDEGYPLIYFIEQFAEIKKLGYQYQYPLDYYFHAGETILYNNTNLYDAILLNTKRIGHGIQLPKHPLLMDLVLKNDIGIEICPISNQILQYVSDMRAHPGLDLLNRGLPVTISPDDPAIFNYGGLSYDFFELTYSWGLNLQQLKQLAINSINHSNTFNQSEYNLLYNAWEVKWFNFIDYIINTYSNI
The following text describes a protein:
Function:
Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATAATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLARRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYAAGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA
The following text describes a protein:
Function:
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (By similarity). May bind to specific miRNA hairpins (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5 (By similarity).
Domain:
The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.
Sequence:
MECPAPDATDAADPGEAGPYKGSEEPEGREPDGVRFDRERARRLWEAVSGAQPAGREEVEHMIQKNQCLFTSTQCKVCCAMLISESQKLAHYQSKKHANKVKRYLAIHGMETIKGDVKRLDSDQKSSRSKDKNHCCPICNMTFSSPAVAQSHYLGKTHAKSLKLKQQSTKGAALQQNREMLDPDKFCSLCHSTFNDPAMAQQHYMGKRHRKQETKLKLMAHYGRLADPAVSDLPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQSPKTLVTLGSQTPVQTQPTPKDSSTVQD
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for ARF6.
Subcellular Localization:
Cell membrane. Cell projection, ruffle membrane. Postsynaptic density. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions.
Sequence:
MEGRNAAAEPFVWVNSASAHSQSVAKAKYEFLFGKSEEKTPDSSDHGGSTLLPPTVTNEFPEYGTMEEGGEGLRASLDFDAKSPPCRLPGQQAVHLLAGQDSILNSVTEGPNDAPQCHPQEQSLQPIDSLISALKATEARIASGTFQATKVLDKDANFSVYQVDKELSTASHKPQRAHRTFPVGPGKSPDIPLSAEVPTEENLSLHIQEDLSALLPEEAQAHRSQITNYRRQGPLRVPESACPVSSSSAGSHNPVDRVGALREQRSDLGREHPRGYDRGGSMGRQGRIKHVEFQGVEILWTGEEAESRHPPERTASPVSKEFAKRPSHSSPACGVCSTSTHLTGDVWDETCKAPSERPGTSAGTLSPMPLGESGEDDVFLRESKEHLEENFAIQGDKERILDQEEHLRGDDDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSVGGQHDVLSVSADGGIVMGYSAGITNGLHDSANSVYTRGPQEIAFWGSRDRCFAEGKTTGVDAGSEMGSTDILEKETTESLSNGTNSNVEAAKRLAKRLYHLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFLKAFSLVGETQERERVLIHFSNRYFSCNPDTITSKDGVHCLTCAMMLLNTDLHGHVNIGKKMTCQEFITNLQGVNEGGDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSEGTDEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKSLSDEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEIYVSVLKEGGKELLTTDGNEPVGLKKSHSSPSLNPDASPVTAKVKRNVSERKDHRPETPGIKQKVT
The following text describes a protein:
Function:
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAAKLDSQLLGLVFQSRPDILKGIQEAADSPARIDLFNNIASFVYERIADNTSEEPATKRRRVEAQTSGPNGAAHPIAGSQAAVLGADAAAAEPVLLEIKDISVSVPQRKKYDLCFTKNFLYARASGSPVPVQGIVYPWKDIEHAFYLPVPDKSQVQHNYVLLPRNSYLPTTKSQQSADQQTQQQTSAPLEPLVFTIPSTAPKPGTITGPSAAAAAPVSDSYATLFHWALTTSLHAAGNHACELVSSDPKVFHSVARQAYRPQEKAVHVKAFRGSKDGFLFFLPTGILWGFKKPLLFLPLDKIVAISYTSVLQRTFNIVVELEGGGEGSEEGGQEIEFSMLDQEDYAGIDQSYVRRHGLADRSMAEQRKAKKQLAENAKKAAANGEEGEGGEGGEAGDGLTELERAQKEEEQRLQDEEDEEEEDYDPGSEGESEGSGSSSEEEEEEEDGEGEGDEDDDEDMGEGLEGEE
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MLFRRLFHHTSIVSFHSSKVMTANQSLLSTLRKKTGYAITNCKKALEMNNNDIEKAETWLNLQAQAQGWAKAAKLQSRSTPNGLVGIRLDTKSAVMVEVNCETDFVSKNEKFQTLVAQITETCFKKSLATVSALDTTQESSLVKLGFDSEQLGSLQLNDSKNSKLSDLLALNIGLIGENMAVRRAAALCATSLNIKFSSCTHPQQVLGESFLGKYAAVFAYEECPPSVETPELTEIIDLEKLPKQLCQHIIGMNPRTIEKSSSEEKAEKSPSEEIKEKSSSDEESALYHQEFLAYPEFTVREVMSHVGWDIKGFLRFECGESLE
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MIIIGIDEAGRGPVLGPMVVCAFAIEKEREEELKKLGVKDSKELTKNKRAYLKKLLENLGYVEKRILEAEEINQLMNSINLNDIEINAFSKVAKNLIEKLNIRDDEIEIYIDACSTNTKKFEDSFKDKIEDIIKERNLNIKIIAEHKADAKYPVVSAASIIAKAERDEIIDYYKKIYGDIGSGYPSDPKTIKFLEDYFKKHKKLPDIARTHWKTCKRILDKSKQTKLIIE
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MPSRGDASGGGGAPTASPAPPQPAKGKGKMKGDDLSEEDRELKARLEECVERAQSPDPRLRVEAIDTLRKEIRAATSSMTSVPKPLKFLRAHYGTLKAYFPRMRNPVQKKHMADILSVLALTTSAEGERESLKYCMMGSLVDICSWGHQYVRNLALEIGQEWKDNGSSTPIESKIELVLEIVKFHMKHNAETEALDLLMEVGYLEVLTGKKYEKYFTMLLDLVDSTNYKRACLYLTSCSIYLLTPDREAYVATLDIAYAMYLKFRDLASALRIVLVNIGKNVKMVFGETTDFSLKQQFTFMIARYGLSVEIDDEMVADENEKNALQEIVYNTKLSEGYHTLVRDIGVMEPKSPEDIYKVHLIGGRGTRSSSLDSLRPNLAAIFVNAFVNAGYCQDKLMTAIPDYLLFKNNELSKASVVASLGMIHLWDPDSGFAKLDKYLHSNDTDVVAGALLGIGIVSCGVKNDRDPALALISEYSKGAASITRIGGLLGLGIAYAGSQKDELKSHFSVILSNPQTPLEDLVFSAISLGLVFVGSCNEEIAGSIISVLKNHSEELAEPTIRLLPVAVGLLYLGKQEMVDATADEVSKALEEPLRKYCGLTLTSLAYAGTGNVLKVQELLRCCSDYEPCHLDLEKGGTGQGPAKSGSSCSWHALHIQSKGVVVDTLSRLSHDADGAVSMAAIISLGLIGAGTNNARIARLLRKLSSQEYGDYLYCVRIAQGLLHLGKGLLTLDPYHSDRLLLSPVALAGLVTVLHACLAMQPIIVKKYPYMLYILALAMQPRMLLTVDEDLKPLHVPVRVGQAVDVVGQAGSPRTITGFRTHSTPVLLAAGERAELATEKYIPLTPVLEGFVILRKNPEHHED