lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK.
Subcellular Localization:
Early endosome. Cytoplasm. Nucleus. Note=Recruited to retromer-containing endosomes via interaction with VPS35. Colocalizes with CLOCK and BMAL1 in the cytoplasm, and with PER2 in the cytoplasm and nucleus.
Sequence:
MSQLSTNLGDSSPPESPVPAVHSRPTVLMRAPPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQLAQPPGLGAPMVQAPPLGGGMAKPPTPGVLMVHQPPPGAPMAQSSTPGVLMLHPSVTGAPLAHPPPPGTPMTHPPGTSMAHPPPPPPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPLTHGAPMVHGGPHGTPMPHVPITGTPIAQQPTPGVLMAQQLTPGVLMVQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSGAPMAQTVLPPGQPLATWAPQGQPLILQIQSQVIRAPPQVPSVPQAPQVQLATPPGWQATTPNWQVTPQGWPATPLTWQATQVTWQAPTIAWQATQPGRQGHSTIRTGHTPIRPGPAPLLRQIPPMIRQIQPVMRQAPPLIRQVPIRPAPHGIASQPQLWQVLPPPPPLRQAPQARLLLPRVPGTGQVSTVPPVAQIHLVPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPKVPPHFWQPVSAQEAQEQATQIAHVEQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQPSWQGPLPMLQAQPGASATLANFPRGSTRSRMAPSGEPGPSSLEPRGPPRERRAPARDKKGPPKERMFIGATFCAPRGASASRAYVPTAWKNLPATSETFPATSRVFPSTSHFQPASSNAFRGPSAASESPKSLPFALQDPYACVEALPAVPWVPYPDGNASSACKSVPAILMVAAAAPQASATAAEASKSSEPPRRPGKATRKKKHLEPKEDNCGHRLSSRDWRGPRTWGNPSHSDWEIQRAMQLLGDRESLYTPQGLNDWGCPNTSRMPRSLEGPSTSRDQEFCGDSGGSQTWMASEVPSVSRGSSAAQEDPDRESQPLSPLDERANALVQFLLVKDQAKVPVQLSEMVNVVIREYKDDSLDIINRANTKLECTFGCQLKEVDTKTHTYIIVNKMAYPQCNLLASYLERPKFSLLMVVLSLIFMKGYCIRENLLFSFLFQLGLDVQETSGLFRITKKLITSVFVRHRYLEYRQIPFTEPAEYELLWGPRAFLETNRVHILRFLAALYENQPQIWSCQYLDSLAELEYKDANAAAEESHDSDDDAHDPTSSPHPH
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MPSASSAVPSAAARGDESQPLAAGAAPNVLLGRYELGGLLGRGASAKVYRARDLVTGRDVAIKSFPNPRAGGRECEGSAAIEREAAILARLRHRHVVRLHEILGTRKKVHFVLDLAAGGELFSLVDSDGRMSEDLARHYFRQLVSAVRYCHSRGVYHRDIKPENLLLDGEGELKVADFGLGAVADGSLHHTLCGTPAYVAPEILSKQGYHPAKVDIWSCGVVLFVLAAGYLPFNDASLINMYRKIYAGRFRCPNWFSPALRHLLRRILDPNPATRIDTDGIMEHPWFCHGAGGDGELEKLMCGHEEEAWFKTEFKEDMARDMTAFDILAFSPGSDLSGLFGPGPGTERVFVGEPAAAVLARVEDAGKKQGHRVRREGKNLAGPVYVEAEVGGIVAKVTVFRVADAVSVVEVVKGHGAEAAAFWSDWLEPAVKPQAV
The following text describes a protein:
Function:
Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel.
Subcellular Localization:
Virion.
Sequence:
MAEKRTGLAEDGAKSVYERLKNDRAPYETRAQNCAQYTIPSLFPKDSDNASTDYQTPWQAVGARGLNNLASKLMLALFPMQTWMRLTISEYEAKQLLSDPDGLAKVDEGLSMVERIIMNYIESNSYRVTLFEALKQLVVAGNVLLYLPEPEGSNYNPMKLYRLSSYVVQRDAFGNVLQMVTRDQIAFGALPEDIRKAVEGQGGEKKADETIDVYTHIYLDEDSGEYLRYEEVEGMEVQGSDGTYPKEACPYIPIRMVRLDGESYGRSYIEEYLGDLRSLENLQEAIVKMSMISSKVIGLVNPAGITQPRRLTKAQTGDFVTGRPEDISFLQLEKQADFTVAKAVSDAIEARLSFAFMLNSAVQRTGERVTAEEIRYVASELEDTLGGVYSILSQELQLPLVRVLLKQLQATQQIPELPKEAVEPTISTGLEAIGRGQDLDKLERCVTAWAALAPMRDDPDINLAMIKLRIANAIGIDTSGILLTEEQKQQKMAQQSMQMGMDNGAAALAQGMAAQATASPEAMAAAADSVGLQPGI
The following text describes a protein:
Function:
Possesses chitinase activity in vitro toward glycol chitin, carboxymethyl-chitin, colloidal chitin, and the chitin oligosaccharides (N-acetylglucosamine) (GlcNAc)6 and (GlcNAc)5. Hydrolyzes (GlcNAc)6 into (GlcNAc)4 and (GlcNAc)2, or two (GlcNAc)3 molecules. Has the capacity to reduce hyphal growth of the fungus Trichoderma viride in an agar-plate bioassay.
Sequence:
MANILNLKHLLTLALILLALATKSSTSSSSSITRVKGIYWLENPFFPPTTVDTSLFTHIFYSFLTPNNITYKLEISSSQILSLNTFTKTFKTKSPPAATLFSIGGAGSNSSLLAFIASDPPACAAFINSTIDVARTFGFDGIDLDWEFPKNTKEMNDLGEMLFQWRKAISDEGATTGRPPLLLTAAVYFAVNFSIYGEPRMYPVNSINENLDWVNVMSYELRGPRSNKTGAPSGTFDPKSNVSVVSGLLSWIHSGVVPEKLVMGMPLYGKSWKLRDPNVHGIGAPSVGSGPGVNGLMAYFQVLDFNRQKSAKVEYDVDTASVYSYSGSTWIGYDNPFTVSIKVGFAQALKLRGYFFWVAGLDTLDWKIATQASKAWKLV
The following text describes a protein:
Function:
Catalyzes the transfer of electrons from NADH and NADPH to reduce quinone to the hydroquinone state.
Subcellular Localization:
Cell membrane.
Sequence:
MATKVYIVYYSMYGHVEKLAQEIRKGAASVDGVEAILWQVPETLQEDVLSKMSAPPKSDAPIITPNELAEADGFIFGFPTRFGMMAAQFKAFLDATGGLWRTQQLAGKPAGIFYSTGSQGGGQETTALTAITQLVHHGMIFVPIGYTFGAGMFEMENVKGGSPYGAGTFAGDGSRQPTELELGQAFHQGKYIAAISKKLKGPAAA
The following text describes a protein:
Function:
Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVLLRKLVHNEAIREDPKEIYGWRVYMLACSACFGGMLFGMETGIIGGVLTMKPFMAKYGLTNLSSVAQANLSANIVSTLQAGCFFGALIASQVADRWGRKPGLISASIMSIVGVIMQVAASGHLEAMYIGRLITGFGVGFASMINPLYVSENAPRAIRGMLTGLYQLFITMGIMLAFWINYGSLLHISGPAMYLVPLAMQALPAILLLVGMLLCNESPRWLARQDRWEAARATLARVRHLPPTHPYVEREFQDIVAQLEHERQLIGGSGPWDLMREMWTIPGNRKRALISIFLMICQQMTGTNAINYYAPQIFKNLGVTGNATGLFATGVYGIVKVVGCAVFLVFVADSLGRRRSLLWTSVAQGLTMLYIGLYVRIAPPVAGEPVIPAGYVALVCIFLFAACFQFGWGPVCWIYVSEIPTARLRGLNVSFAAATQWLFNFVVARAVPNMLATVGANGYGTYIIFSCFCLSMGVFVWFFIPETKGLSLEKMDELFGVTTPQDSKVADAERAMSSTDKEAEAETAVETRVERL
The following text describes a protein:
Function:
Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus.
Sequence:
MAADVFMCSPRRPRSRGRSVLLKPQVPEDDDDSDTDEPSPPPPSGVATSARAHASAAPLPPRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQTYSFGKTSSCHLSIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRRNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSSLAQDDDMLYWHKHGDGWKTPVPMEEDSLLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLGNADMIQPGLIPLQPNLDFMDTFEPFQDLFSSSRSIFGSMLPPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQPFLPVFTMTLLSPGPAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATTFSQNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEPVSLVLKNACIAPAAFSGQPQKVIMTSAPLKREGILASTVSPSNVVIASAAITRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSLVKGEQVSLHGGSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSPQNNCSGKSTDPKNVAALKNRQKHISAEQKRRFNIRMGFNTLNSLISNNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEIEELNTTIISCQQLLPATGVPVNCRQLDHMRDMFDEYVKSRTLQNWKFWIFSMIIKPLFESFKGMVSTSSLEEFHRTALSWLDQHCSLPVLRPMVLSTLRQLSTTTSILTDPSQLPEQASEAVTRMGKRSGES
The following text describes a protein:
Function:
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNDLPTKKDLVKWDQEDALNWTRGEYEIPNSKACGGEADGKAIYFCGNSLGLLNKKARQHIMEELDVWSTSSVTGHFNHPYQRPWKHVDEPLTPHLAKLVGAREEEVAHTSTLTSNMHNLFTSFYQPTEKRWKIVIEKGSFPSDWYAVHSHPRLHDKVLRPEQIDNAIIALVPREGEDTLRTEDILKVLDDNKDSIAIVWLPLVQYYTGQLFDISSISPKVHEIGALLGLDMAHGIGNVECKLNEWNVDFAVWCTYKYLNAGPAAIGGFYIRSGLEDGGRRLAGWWGNDARTRFHMSPNFQPTPGAKGYQHSCTPVFSSIPLLATLQLIEAVGFSNMVEKARRLTGTLEALLKASRYHVHPADPKGKIGFKIITPAAPYRGTQLSLVILPEEEHVMPKVFDRMLRKGLVGDERKPSVIRLSPVVLYNTFEEVGRAVEIVEEALEEEEEERKR
The following text describes a protein:
Function:
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MNRSELVAALADRAEVTRKDADAVLAAFAEVVGDIVSKGDEKVTIPGFLTFERTHRAARTARNPQTGEPIQIPAGYSVKVSAGSKLKEAAKGK
The following text describes a protein:
Function:
Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSHSTDHSGASHGSVKTYMTGFILSIILTVIPFWMVMTGAASPAVILGTILAMAVVQVLVHLVCFLHMNTKSDEGWNMTAFVFTVLIIAILVVGSIWIMWNLNYNMMMH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAAGLSVNIAIEQLLESEVEEIARDGQEKYVPQLSMSEQLSKLAHKIDFLSEAKSKADDNADDNDDESDNKTLVTFQPSLWPWDSVRTKLRNALTEVCVLSDLLNVVKEKKYVVLDPVSQSQAISKPTLQLLAKKKNLRDAATILLQGSKRMESAVQERMSQQSRPDQERSDFHSELINLRQRWRLKRTGNSLMGDLTYRSAGSQFWNPGLFEVTKPTGVDNTHGNTPAPSVSGALEVKVSSDLEGVAEVNVQIVESGTDVHMYSGKSKVLAKMNSRQPWQGKLEAAQRNLFCKELFTQLSQEAYSSRGTTTNLVMGNEIRTEVFPGLELCITYSHNKTTSTDEDPTPKDETMSQDPHEQPEALNLHPLEYILHSLLRRRHKQNQTMAPPNPVTAHLIPGTSKKLRLAGPGALRSSEVASSYENEPILNTIISVAKHQILKTKVMEMIGKLSSEVTDPCLQCNWASVSSEIAASAVIHIHAPELQDSGRVSVRLQIGIQEVQATCDDGRSVTCSSHVQDLKDFLLSQVAQHRVLVAHTMAVSLGWHVIHHSNHVATGPVEYQGHAAGLVVTSPDSDRSIAVRAGPSSGISVAVRRPRGSLPDFLSDPKWSLVGSEFVSVDLQSMPGRTFVQKMYLLLGVEMSLKN
The following text describes a protein:
Function:
May be involved in the control of meiotic sister-chromatid recombination.
Miscellaneous:
MISCELLANEOUS: Present with 131 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Cell periphery.
Sequence:
MVFGFTKRDRRVPDLSRYDYYYQNHEDYNKSPQLSAAAASAASAASPDRTNYSRSHSLVSHAPSIPRQRSSVKSPGRRLSTSSAAPPTSRAAAKQYSQKTYSLRSQRSGEYHLHPPGYTTNGSRMNSMTSGANVRRNYGKNKSTAGNNNDSRANSITVKTTQVTDPSGRTQSITKKTIRKINGYEYVETTTTTKNLVPLGDSQRHFDEFSENYMLQDDDILEEQASDNIHDIIEENETDNEKPYSPVSESHLQDDSELNVEKPDFPLGSYFHHKYSTDVMPLEEESSLSNFSDALDYIPPTHQTSSKYIHNKRKQASTTRRKKRPPAVKNAEAEAKKPLTEAEMYLKALEVAKRNVYHTDAASDNASAPLGSNKSRKSRMGQKMTLRSSSDSPTATANLVKSNVEVQPKRFTSSFFSRNTKSAPHEVHNHSVSTHFKSNKAVDPVPEPKSANTGLTDKEMYDQALKIAQARYYNSHGIQPEAVDNSTTAAKPRQVGVSHLGSTGSIPPNEQHYLGDSEIPVQSEVHEYEPIPLQKTKTTGSSKNKFKTMFDKVLQFSQENYGYQHKKEQGEQTPVTRNAEESFPAASISEGVTTAKPSSNEGVMTNPVVTDSPSPLQQQIDSTTASSNGQSQGNVPTSAVASTTRTRSPELQDNLKSSSSLLQDQTPQRQEDATDPTTSSTNELSAAEPTMVTSTHATKTIQAQTQDPPTKHKKSSFFTKLFKKKSSR
The following text describes a protein:
Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSSDSKAATDEEIRRALKAADLMKILDGKIALGNKSGTKNLGEHKFWKTQPVPQITGSGAPAPIEEGPIDDPKTPADVRQEPGVLPAGFEWSTIDINDEEQSKEVYVLLCENYVEDDDAMFRFNYSREFLLWALTAPGYLPDWHIGVRVQKTKKLVAFISGIKIDIRVRAKTFPAAEINFLCVHKKLRSKRLAPVLIKEVTRRVNLTNIWQAIYTAGVILPTPIGTCRYFHRNLNPPKLVDIGFSPLPRGSTIARLVQQYSVPSHPRIPGFREMKKEDVPQVGALLRRYLDRFDVAQAFRDDDEVEHWLLSGQGKEVGGRRVEQVVWAYVVEDPTTHRITDLISFYALPSTIMKHPKHNLLNAAYMFYYATDVVFPPSSSSANSDVDVDANAGESSVAAVGTGGEDAKTKKKLETRLNALTADILIIAKQAGFDVFNALTLLDNNMFLQEQKFGPGDGYLNYYLYNWNCAPIDGGHHSTTAKQGSKIGVVML
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MENESLKNKTIMITRPEWQGELLKKAIERRGGAVILFPTLIIKPINKCNYSPFASASFPPSRESGSPDDKMTKAGFLNSSDILIFLSANAVKHSPILNFKAEQKLVAIGTGTAAALFQRGLSVDAVPEHFSSEGLLDLPLLHQVTGKTIAIFCGENSRPYLENELIHRGANVFSIITYRRERPVVNKKTIDALTHQTLHAIVSTSAESLQNLCTLFESHQHWLHRIPLVVISKRMENLAKSQGFHLVLLADNPGEKAIIKVLSTKYPS
The following text describes a protein:
Function:
Putative pheromone receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLTYDDFMCIFHKLQTIIGLFGNSFLLYLYILKLIINQRITLIDKICINLVFSNILMVIFKGIPWAMQACNQKIFMSDIECKIIIYVQRVSRGISLCTTCLLSVFQAITITSCSPKWAMLKARVLKSVVPACAFIWVLNLLIDLVVPLHVGALRSGNNSQLTRNLGFCSVDNYALSTIKIVIWKTLYDAVFMGLMSITSGYMVLILYRHHWQVQHIHHPSFNPSASAEIRATKFILCLMIIFVCFYSLSSIFVIVMDNSKDTKQWVVNISVFFSLIHPTVSPFVLMSSDSKNASYCNIFKWMKKSYKHSSKNPE
The following text describes a protein:
Function:
Binds preferentially single-stranded DNA. Does not bind to RNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSLISKSLARIECSPFFYPRASEITTGKRITSPQIRLYTAAAVGGKTGNGERKQRAKAPAKTPEAVTPVKPLEIASVTATTENELPRPNEIAYESEVANWVNLIGFVDQPVQFEASSDGKFWAGTVISQRSASDSSGFWIPIIFEGDLAKTAARYVSKDDQIHVSGKLFIDSPPPNMTYAQANVQVLVQNLNFIQPMSPSPSPFMVMSSSEKEESGIKKQPARAKQDIVIDEASDSWNHLIENPKEWWDHRENKVNGLVKPRHPDFKSKDSSFSLWLNKAPNWVLPKLEGLEFDVLVPKARVVKQLKGEESWKDLVQNPDKWWDNRIDKRNAKAPDFKHKETGEALWLNESPTWVLPKLPPVKKKQESIVF
The following text describes a protein:
Function:
Catalyzes the synthesis of citryl-L-2,3-diaminopropionic acid from L-2,3-diaminopropionic acid (L-Dap) and citrate, the first step in staphyloferrin B biosynthesis.
Sequence:
MQNKELIQHAAYAAIERILNEYFREENLYQVPPQNHQWSIQLSELETLTGEFRYWSAMGHHMYHPEVWLIDGKSKKITTYKEAIARILQHMAQSADNQTAVQQHMAQIMSDIDNSIHRTARYLQSNTIDYVEDRYIVSEQSLYLGHPFHPTPKSASGFSEADLEKYAPECHTSFQLHYLAVHQDVLLTRYVEGKEDQVEKVLYQLADIDISEIPKDFILLPTHPYQINVLRQHPQYMQYSEQGLIKDLGVSGDSVYPTSSVRTVFSKALNIYLKLPIHVKITNFIRTNDLEQIERTIDAAQVIASVKDEVETPHFKLMFEEGYRALLPNPLGQTVEPEMDLLTNSAMIVREGIPNYHADKDIHVLASLFETMPDSPMSKLSQVIEQSGLAPEAWLECYLNRTLLPILKLFSNTGISLEAHVQNTLIELKDGIPDVCFVRDLEGICLSRTIATEKQLVPNVVAASSPVVYAHDEAWHRLKYYVVVNHLGHLVSTIGKATRNEVVLWQLVAHRLMTWKKEYANNAVFVDCVEDLYQTPTIAAKANLMSKLNDCGANPIYTHIPNPICHNKEVSYCESNNS
The following text describes a protein:
Function:
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Mitochondrion.
Sequence:
MLRLARPLCVQTVKASKLSRLWSRPAALMSTLLIHHPQYAWLQDLGLREDNEGVFNGSWGGRGEVITTYCPANNEPIARVRQASMKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDALREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALMEQWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSIAVTKIIAKVLEDNLLPGAICSLTCGGADMGTAMARDERVNLLSFTGSTQVGKQVALMVQERFGKSLLELGGNNAIIAFEDADLSLVLPSALFAAVGTAGQRCTTVRRLFLHESIHDEVVDRLKNAYSQIRVGNPWDPNILYGPLHTKQAVSMFVQAVEEAKKEGGTVVYGGKVMDHPGNYVEPTIVTGLVHDAPIVHKETFAPILYVFKFKNEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTALPLAQGIKFQ
The following text describes a protein:
Function:
May be involved in extracellular digestion.
Subcellular Localization:
Secreted.
Sequence:
MKNIIAATLMTILISFSFYQVNLDSDSDFERWALKHGKHYFGDEKKYRQAIYFQNKQMIEEHNKRSEFTFLMGENQFMAITNEEFVSLYLNPISPEKQNEQDQIIRKTNPKSPEPIREYNLKDDVDWRGYAPVKNSGNCGSSWAMAATNVIEAAYAIDKGIKVTLSAQNVMDCANSWGGCDASLADFSDPKNAYGHARNRGILTESEYPYTGRGDDWCQQTGFAPWRIMSYAQNSDDIDYMRGFLQMLTEHPLSVKVDATNWQFYSSGVFSLCSSIYKKANYYALAIGYVWEANQQQNWQQIWRVQASFGISWGEFGTIRLAPGNTCGVINEGIRVYLWGG
The following text describes a protein:
Function:
May be involved in cell cycle regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEDGSCPYEVLGIEMTATIEEIRKAKRDMSRKYHPDKHMNVSESEKKRLRIKFDALGEAYELLSDETSRAKYDAKLKAKQAAQVRHAKLNEEQRKAREAPSFTLGACGVSWLLVQTHDEQIKRLRAEGIERLEAEQVRIEAELQRAHDASNRRAAEASQHGVLKLEAMLRERSRGAQNGLKKIELMTTETTGTPLTAEAPTTTEADIAPDEGMDLEDMEAMLMAKIAQSATQKQHHFLFELQKHSMAGRGLGFGRLARPPPPPPPPPPSSAVQAPAQPDHESDRAEPTPKPEQSSVPTALASTTTPSPAPAVVKAPASKGALAPTATHKADAQQDKVSTTSTLKPTLLAKRPKLTVAEAFGGDEDEDEDEEEEIPAAMRIRMRNVGSETRTSAGPNSYGKSKRGFTWRTRTWETEAEKLAAEQEQEHDGPDSSSAQ
The following text describes a protein:
Function:
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Miscellaneous:
MISCELLANEOUS: Calcium is required for ligand binding; MISCELLANEOUS: Two types of rat hepatic lectin have been identified, RHL-1 and RHL-2/3, having a relative abundance of 4:1. RHL-2 and RHL-3 only differs in their carbohydrate structures.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MEKDFQDIQQLDSEENDHQLIGDEEQGSHVQNLRTENPRWGGQPPSRPFPQRLCSKFRLSLLALAFNILLLVVICVVSSQSMQLQKEFWTLKETLSNFSTTTLMEFKALDSHGGSRNDNLTSWETILEKKQKDIKADHSTLLFHLKHFPLDLRTLTCQLAFFLSNGTECCPVNWVEFGGSCYWFSRDGLTWAEADQYCQMENAHLLVINSREEQEFVVKHRGAFHIWIGLTDKDGSWKWVDGTEYRSNFKNWAFTQPDNWQGHEEGGSEDCAEILSDGLWNDNFCQQVNRWACERKRDITY
The following text describes a protein:
Function:
Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor. Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression. Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions.
Subcellular Localization:
Nucleus.
Sequence:
MALGPAFQDREGLLIVKLEEDCAWSQELPPPDPRPSPEASHLRFRRFRFQEASGPREALSRLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQKELGRLRKKVTNHGRGTEVLLEEPLPLETAAESPSFKLEPMETERSPGPRLQELLGPSPQRDPQTVKERALSAPWLSLFPPGGNMEDKELTGPQLPESLEDVAMYISQEEWGHQDPSKRALSRDTVQESYENVDPLESQVPSQEALSTQVEQGRKPWDPNVQICKEGLSPRSPAPGEEKFENLEESAQSVSLENIHTQALLPGQARGEAPWSLEQRRPQDRAEEHRGLPPEDRMEQSFVGAASCRELGRPKELQPKKLHLCPLCGKNFSNNSNLMRHQRIHAAERLCLGVECAQIFGGNPHFLSLHKAHLGEEAHKCLECGKSFSQNTHLTRHQRTHTGEKPYQCNVCGKSFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCAECGKSFSRSSHLVIHERTHEKERLCPFSEGGQAVSDSSLFLTNHGTHKAEKKLFECLTCGKSFRQSMHLTRHQRTHTGEKPYQCTLCGENFSHRSNLIRHQRIHTGEKPYTCQECGDSFSHSSNRIRHLRTHTGERPYKCSQCGESFSRSSRLLSHQRTHTG
The following text describes a protein:
Function:
Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSSPHRASTTQQLADLSLTEGEHDEGKPLSIDYLQGHEGLIEEVLKWSEHEQLDFMDKIVHRLSHYQLGKVDNFIRPMLQRDFISNLPAHLVELILFNVNSDSLKSCEEVSTSWRCALARGQHWKKLIEKNVRSDSLWWGLSEKRQWDKFLNISRDMSVRRICEKFNYDVNIKRDKLDQLILMHVFYSKLYPKIIRDIHNIDNNWKRGNYKMTRINCQSENSKGVYCLQYDDDKIVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQYDNRVIISGSSDATVRVWDVETGECIKTLIHHCEAVLHLRFANGIMVTCSKDRSIAVWDMVSPRDITIRRVLVGHRAAVNVVDFDDRYIVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQYRGRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRFDEKRIVSGAYDGKIKVWDLQAALDPRALSSEICLCSLVQHTGRVFRLQFDDFQIVSSSHDDTILIWDFLDAPPSGLPSSTNRATLPELPNQAAVARAQMLFEMAARREIERRDREVVEEPALRPRANAARRHNADIAAAAAAAEAARGAGDNDESSSEEDLDRVDQVNNPNVAGPAPPQPHNQNHRRRQPRPELPVRLMQEMAAFDNMRRQQNNMDHLGGGDVDEEMPDGGP
The following text describes a protein:
Function:
Calcium-permeable, cation-selective stretch-activated channel (SAC) that functions together with CCH1 to mediate calcium entry into cells. Required during mating.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MFFFSTHLILKILFFWSITRNIFGATYTSLLLNNTINGNINDQSTAYYNLTWEGNTAYNVSLTLSTCTAFDGANDLMLYISNNTFDEALPLDNFTITASENGLATIFVTGYSPLYIAVSSAFSQFAPNFFVESGESTLEGNNVINYELAAGIDTPFSQYNATKFLFAQDTDFQAALLITGNLTTNETSIIPSYEIYVNPSNSTYDNTFNKFSSSFCAFQNNPSTVNTNNADRSMTLRGLGPFAKEQFYLKGLDPNVTYTAYLVEPNIGQPGGTVYPGVTFTTKTSPACQLIYDLQFCSEVAYAVPGNSSLFSASALAEWYDQQAYGYYQNFTYTLDLIPCNATSWSAYSLLKNCSDCANSYKNWLCASVIPRCADINDNSSYLIYKNYDSRYPLIDEVIQPGPYKEVLPCSYLCYSLASSCPLDLGFACPKAGYGLEFSYGEVSNVTGLITCNAPGVEFYESGSALLNISWRTFFISLIFWILFVE
The following text describes a protein:
Function:
Involved in the pentose phosphate pathway via hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Miscellaneous:
MISCELLANEOUS: Present with 4320 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MVKLQRFSEKKSLIHEFGKFILEKQESALTGDADAVFNIAISGGSMNQALYESLVNDKNIFPHIKWPQWRIFFCDERLVPFEDPQSNYGQFKKTVLDPLVHQGNQLNLGPTVYTINESLIGGGETANRKIAEEYASMLPASFDLILLGCGEDGHTCSLFPGVEFNYLVEEMDRKVLWCNNSPKAPKDRITFTLAVVAEAKSVCFLVRGAAKKAIMHDVLIVKNSELPSVLVNEMVGTKVTWFLDDEAGALIPENC
The following text describes a protein:
Function:
Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation (By similarity).
Sequence:
MNLCSSGATASTTSLSSTGQAERSGGVPGGGAEGGGGSGNSGGGGKTSNGSAEAPTLCFAGGSGTAGAIAGTEELSNANSPANGAGGATGSTGSGQQPTGSNGHSHLHNENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQM
The following text describes a protein:
Function:
Removes the 4'-phosphate group from lipid A species. Absence of phosphate groups in lipid A renders the bacteria resistant to host-derived cationic antimicrobial peptides (CAMP) and allows it to camouflage itself from the host innate immune response. Removal of the 4'-phosphate may be required to generate the substrate for deacylation of the pentaacyl lipid A to the tetraccylated lipid A species.
Miscellaneous:
MISCELLANEOUS: When grown in low hemin conditions the major lipid A species are non-phosphorylated tetraacyl and 4'-phosphate pentaacyl lipid A, while under high hemin conditions the major lipid A species are non-phosphorylated tetraacyl and 1-phosphate tetraacyl lipid A (hemin is protoporphyrin IX containing Fe(3+) with a chloride ligand (CHEBI:50385) involved in the change from healthy to diseased gums).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEYILEVERNLFLTLNGVQHPLLDGFFYLISAKWTWVIMSIAFLFFLFYKKPTKEALFIVGAVLLSVLICDQLSSSFFKPFFARFRPSHHPDFIDYVKTVYGYRGGKYGFISGHTTNYISLALFTSRIFRNKFYTWTIWSVVALVIYSRIYIGVHFITDIIPGIAVGLIVGHFVYKVYLYARSRWLGASCPAHPSAVYAGDSIRLWTLSLIGFVFAMLCMSRQLTEILQYYVFLLF