lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Photoreceptor synaptic protein essential for normal vision. Involved in synapse formation in cone photoreceptor cells.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cell projection, dendrite.
Sequence:
MWVALGMLWLLALGGPHQAWGFCPSECSCSLRILSDGSKARTVVCSDPDLTLPPASIPPDTCKLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSALMLRGLRRLRELRLPGNRLVTFPWAALRDTPQLQLLDLQANRLSTLPPEAAHFLENLTFLDLSNNQLMRLPEELLDVWAHLKTGPFLSGHHARLILGLQDNPWVCDCRLYDLVHLLDGWVSSNLIFIEARLRCASPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLGSTVLLRCGATGIPGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETLISLIVTEPQTSTGYSGIPGVLWARTGEGAEAAAYNNKLVARHVPHMPEHVALATKPSMPSIKEELALQNFQMDVPGEFSREPSEHQEAQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGHRDMRRMTVEPGKTSVTIEGLAPKTKYVACVCVRGLVPTKEQCVIFSTDEVVDAEGTQRLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRTGGSAEASGAYVNLERLGHSEDSSEVLSRSSLSEGDRLLSARSSLDSQVLGVRGGRRINEYFC
The following text describes a protein:
Function:
Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation. Acts as a pattern-recognition receptor for NETs in neutrophils: specifically recognizes DNA in NETs, leading to inhibit neutrophil activation and limit further NET formation. This regulation is essential for controlling key neutrophil responses and limit NET-mediated inflammatory conditions. Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation. Binding to monosodium urate crystals also promotes the type I interferon response. Acts as an inhibitor of natural killer (NK) cell cytotoxicity (By similarity). Also acts as an ihibitor of dendritic cell maturation in an IL10-dependent manner.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization.
Domain:
The immunoreceptor tyrosine-based inhibitor motif (ITIM) is involved in modulation of cellular responses (By similarity). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing protein phosphatases, such as PTPN6 and PTPN11 (By similarity).
Sequence:
MSEEIVYANLKIQDPDKKEETQKSDKCGGKVSADASHSQQKTVLILILLCLLLFIGMGVLGGIFYTTLATEMIKSNQLQRAKEELQENVFLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR
The following text describes a protein:
Function:
Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.
Sequence:
MNPRELAMADEARSRLGRGLASLIGDVGGEAQHVDRPRAQRKVPIEFIKPNPRNPRRTFSETELKELSDSIRQHGVIQPIVVRPVKGAQDRYEIIAGERRWRASQMAGLHEVPIVPVDISDSDALEFAIIENVQREDLNPMEEAQGYHALANEFKRSQDDIAKVVGKSRSHVANMMRLTKLPAEVQAFIATGQLTAGHARALIGVPDPLAAARRIVEEGLNVRQAEALAHEEGVPERKPQKARSTGGKEKDPDTIDLEKRVSDALGLKVTVNHRDPGGSVQINYRNLDQLDEVMKRLAKGAL
The following text describes a protein:
Function:
Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N-acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine.
Sequence:
MIARETLADELALARERTLRLVEFDDAELHRQYNPLMSPLVWDLAHIGQQEELWLLRDGNPDRPGMLAPEVDRLYDAFEHSRASRVNLPLLPPSDARAYCATVRAKALDTLDTLPEDDPGFRFALVISHENQHDETMLQALNLREGPPLLDTGIPLPAGRPGVAGTSVLVPGGPFVLGVDALTEPHSLDNERPAHVVDIPSFRIGRVPVTNAEWREFIDDGGYDQPRWWSPRGWAHRQEAGLVAPQFWNPDGTRTRFGHIEEIPGDEPVQHVTFFEAEAYAAWAGARLPTEIEWEKACAWDPVAGARRRFPWGSAQPSAALANLGGDARRPAPVGAYPAGASAYGAEQMLGDVWEWTSSPLRPWPGFTPMIYERYSTPFFEGTTSGDYRVLRGGSWAVAPGILRPSFRNWDHPIRRQIFSGVRLAWDV
The following text describes a protein:
Function:
Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. Reduces both benzoquinones and naphthoquinones efficiently; Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines. Preferred substrates are the large bis-azo dye Ponceau BS, amaranth and tropaeolin O.
Miscellaneous:
MISCELLANEOUS: Rate of quinone reduction is higher than reduction of azo substrates, suggesting the enzyme is better suited for carrying out quinone rather than azo reduction.
Sequence:
MKLLHIDSSILGDASASRQLSAELVQAWRQNEDGLDVTYRDLAADAVAHFSALTLAAGSTPAELRDAALKHEVAVGEEVLEEFLAADVVVIGAPMYNFTISSQLKAWIDRIAVAGKTFRYTENGPVGLAGDKKVVIVSTAGGVHAGQPTGAAHEGYLRTVLGFFGITDIEVVRAEGLAYGEEPRTQAIAAARRQIAGQFAAA
The following text describes a protein:
Function:
Catalyzes the NADH/NADPH-dependent oxidation of L-idonate to 5-ketogluconate (5KG).
Sequence:
MQVKTQSCVVAGKKTVAVTEQTIDWNNNGTLVQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIHSDSSELHEGQTVAINPSKPCGHCKYCIEHNENQCTDMRFFGSAMYFPHVDGGFTRYKMVETSQCVPYPAKADEKVMAFAEPLAVAIHAAHQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSFEVSGHPSSVNTCLEVTRARGVMVQVGMGGAMAEFPMMTLIGKEISLRGSFRFTSEFNTAVSWLANGVINPLPLLSAEYPFTDLEEALRFAGDKTQAAKVQLVF
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MAAKTAAVDFARVASALNLPQSTLQSLSAFRARNAAAKASLSALKSQKQDIDFAHYRAVLKKNTQIVDRLEKVWNDFKPAEYDVAAQIKAIEAFESKAVSSASEASQKIEEELAALNATLQNIEGARPFDQLTLSDIDKAEPRISKTVETMVKKGKWTVDGYSEKFGNLSVM
The following text describes a protein:
Function:
Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of ypt7 and rhb1. May be involved in vesicle trafficking and protein sorting. Required for forespore membrane formation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVNDFNEKNGIKKRLLDFFPVVLEGIREILESMQYFPEETEKLLYSIKRNTLGGKNNRGLAVLQSLTSLINRELEEAEFRDAALLGWLIEILQGCFLMADDIMDQSIKRRGLDCWYLVVGVRRAINESQLLEACIPLLIRKYFRNMPYYVDLLDTFREVTFLTELGQQEDLLSSRDGEASLRSFDLMKYDFIITYKTSFYSFYLPIKCALLLSRNSNQKAYDTTIKLSKLLGYYFQVQDDYLDCFGDYTVLGKVGMDIQDNKCTWLVCYAEKFASADQLNLLRAHYGKAGSENIAVIKQLYHELQIPELYHKFEDDMVDSISKEIDLIDESTGLKKCIFTKFFQLIYKRSR
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNIYIQQIIINYNQFLMYEQELPSNLDDFPNYNLKQSTESEKVVVDDDQKKKAAYQFMQSLEKNLRTKISSPQQRVQTLAVSLELYDTIFNKIYCNTLYKDTLFPLAESLEEAFNDEFDSITKLLFNESCYRHAFQSVQQQFNLQTSIESWQNYQLLFAALQQKQNIDLPLPPSWIWDILDEYVYQFYVSSRWRKLLKNDEITQVKNIQDYWNLEEILKTLEAFYSQRNSAVQNTFQYLAYYSYLATAKLQVMSGNFNAAYTMLSQIQHSELIIYSKSGGAYQSLFSYAGFCFLLNKEYKKANLTLTLIVNYFNKYKQLYTKSYQYDSLIKQHEKILALLAVTSIFYPELEDNIITLLKESRNKLFEKYEKILKYDQQLIGEVFLQSCPKIINTIKNIKEFQTEQELNPNETIIEVKDKLLKEILEAKRINDVEQVLSLYNQITFEHFNKLLPQKYVQLYIDRNSVALNENSFESTILSKFWQKSKLLEIEIKNNIIHVKEVQVNQRDFINQLAQMNASLEKNIQELSKNL
The following text describes a protein:
Function:
Catalyzes the formation of proponate and pyruvate from (2R,3S)-2,3-dimethylmalate. Has no activity toward dimethylmaleate, malate, citramalate, isocitrate and citrate.
Sequence:
MNTAAKMRELLSTKKMVVAPGAHDAMTAKVIGRLGFDAVYMTGYGQSASHLGQPDVGLLTMTEMVARANAIVEAAGVPVIADADTGFGNAVNVMRTVREYEKAGVAVIQLEDQVMPKKCGHMVGREIVSKEEMVGKIKAAVDTRVNPDFMIMARTDARTTKGIDEALERGLAYKEAGADIIFIESPEGEEEMKRINETIPGYTLANMVEGGRTPLLKNAELEALGYNITIYPTASIYVATKAMVDLWTALKNDDTTAGVMDTMVTFSEFNDLMGLEKIREVEHNYATGR
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
Sequence:
MPFQDYFQKKKAAFINRNNKSNADASALRDINDININFAAKSKNYVFPLTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATKLLYRRIYLNDSNVVKSDFMHLAINWTLLNLPSSLKEEESRDIANCKLKKLIETLQNNIHITEVIQWIRINWDLDSTLQRSILSILCNQGKSLQRLENVTDPACNDIISNGHFSRSNVSSFDMAPPNSLPEMVVPENYIPNLTKYLSQRISSRLSHMTLFIDPLKLFNYLYPLDIKLQIIDLKLHWRREFYNNDYFVKKIRPGNPLTKLSEVFDKRTLKILTIISWNDTLLKRETEMLKDFKEFENLEDLSLISIKQDVHILVDLFSSLTNLKRLKMDFLEEYVPEPTNPHIFLSILLACSKLQFIDLRYDGLIPQIINIQENKFQLNQQCNCTNCQIVFSDILKGKIFMFPEDYYIHDLQDIAAKDIFKMMKYLSLLPYSKACDAYPSVRTQPMNLTNFVTKMNRNLLEYRNSKSQLVPKIVNNPHQHSTVTSTSTAHMSEPEMIIIDDDDDDDEINAAIPPSSDDTAATISTDLELPHESLTKRDIIMCYHALIHHFKSIYVTFLKSFPHLRFLMLNDIPTIVMEENNERIFEPVFYHYDYKSNLYGWSKESNKNLENDSNNNNNNSDTIARIATVM
The following text describes a protein:
Function:
Probable transcription factor involved in plant development.
Subcellular Localization:
Nucleus.
Sequence:
MTKTRILNPTRFPSPKPLRGCGDANFMEQLLLHCATAIDSNDAALTHQILWVLNNIAPPDGDSTQRLTSAFLRALLSRAVSKTPTLSSTISFLPQADELHRFSVVELAAFVDLTPWHRFGFIAANAAILTAVEGYSTVHIVDLSLTHCMQIPTLIDAMASRLNKPPPLLKLTVVSSSDHFPPFINISYEELGSKLVNFATTRNITMEFTIVPSTYSDGFSSLLQQLRIYPSSFNEALVVNCHMMLRYIPEEPLTSSSSSLRTVFLKQLRSLNPRIVTLIEEDVDLTSENLVNRLKSAFNYFWIPFDTTDTFMSEQRRWYEAEISWKIENVVAKEGAERVERTETKRRWIERMREAEFGGVRVKEDAVADVKAMLEEHAVGWGMKKEDDDESLVLTWKGHSVVFATVWVPI
The following text describes a protein:
Function:
Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MDLKFNNSRKYVSISVPSKTQAMSPHIKSVEDVVVLGVNLSKFSKLTQFLICVAGVFVFYLIYGYLQELIFSVEGFKPYGWYLTLVQFAFYSVFGLIELQLTQDRRRRIPGKTYMLIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNLADVSAAVCMSLGLIWFTLADSTIAPNFNLTGVMLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLSCTSGLGPAVAFCSKNPVGTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTVVLSFLFFAKPFTFQYIWSGLLVVLGIFLNVYSKNMDKIRLPSVYNMIKKAMDMKKSRTLAQTV
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: A number of isoforms are produced. According to EST sequences.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MDIDGEDVSRRLHVKFVTKLDSPFKVPVNSVAIPSNVTRLGLSSIVNSIIESENPEWKTEPFDFLIDGELIRMSLEEFLLAKGISAERTLEIEYIRAVTPRKEEEPSLHDDWVSAVNGSSPRFILTGCYDGLGRVWSSAGSCSHILEGHSGAISSVALVNSNDAETVTVATASKDRTLRLFKFDPAESVDSTTKVRAYKILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNESTSEGESVSVKKRKGNNQAEESQSEGEAVTSLVGHTQCVSSVVWPEHDVIYSSSWDHSVRRWDVETGKDSLNLFCGKALNTVDVGGESSALIAAGGSDPILRVWDPRKPGTSAPVFQFSSHSSWISACKWHKSSWFHLLSASYDGKIMLWDLRTAWPLSVIDTHNDKVLSADWWKGESVVSGGADSNLRISSGIAIS
The following text describes a protein:
Function:
ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAENLSDQDCFEKLSSSKEGQHWFCSGLLTQYIQPTFFWFAHDETPSFKWVLNAYHERLRSCTSCIQAYYELRNESLAKGSYSFTGFSITDLQEKWNKWDIIRVLEDFKALEDETIDFTSLPCLIFETLLNPKLFTCKNIYKNAIDAFNGLLSDWCSNIFLPGYLLFFYEASHPDVLEWVHSFFKENTEIRISSATVDAVFNTVVFESQNSSDSDCNFVSISSPEFWERTYMFLELLPLQSITAACESILKDYLLNLVKTSESLSSQQMSCLRICCNSSSFWSAADSFKEVSSFLKNLLKNVTATPFEVSDMNWAYIIASFFRTCLNDFVSVFPEWLKGFVEEKRTIGFIIYSVLDALFDLLSLDYSSPSFLNNTLSLMNANSITILQDYPEYMLKLRLHSLLYDIAFISWSHKAITKNPSFVFDPSYELSPFWKLDNLQEEKISDVLFSKISSCCFAHDIEISENSTPSGTMVQFAELWQVMSEYISGFLKGFSEKSSTEISNMLGDSSKFDTVVSFLLSPTQPLYVSAFHIVQIITNCTKNRNEALKKLVAMDFRGIVHGLADAVLNWQSILSFFPALRIMRFLSITNKSLSSDNSAFTENDIPTLGAYWQCIWNILDLVFSNVARWSLNNPADTVKALMKLTLKFVDDLFQNDGIFIKLLAKFDSLILLGETSESLFSFIMWLKINDLELRGIVINSLCKLFTKFSNFDYLFEDRTVTFLTDFIIRKQKAHLSADQCKQLANVLTQASPEAKTVLEQHRLSEMRKTKKQTELTNSAHVIKPSPTPQITVKQNTTKSSSAPRMGMLEQLKQEYLTKRNFESKLKSSAVSSRKPTFNEVKPANLLAEDLSDNEDDIDRKQGLFSLAKANKIPEIRQQERRQVQLLSNSTIKMHPSQIRMMTNRNVANVKARLFPSMTDFYKEILSWEPANQSPNPVLKFHKLDGKIIDSFKTVEHYMEVLQPMIFMECWSQIQSTKLDLKFSPVEGIMVERTAVNNFVDIGVSVAPKDLYGYPLYDTEVVSLAFNKEDASSMKGLCCFAKVERIVRQTNGVLVVLRTLPSMEILNKLQGNCALWFLKLTNLATFTRQYAGIRGLPYFHLADDIIRARPCSQPVKHSSSEIKAAMKRYQVNEPQAKAIMCALDNNGFTLIQGPPGTGKTKTIIGIISALLVDLSRYHITRPNQQSKSTESKQQILLCAPSNAAVDEVLLRLKRGFLLENGEKYIPRVVRIGNPETINVSVRDLSLEYQTEKQLLEVNQGAIDLGSLQELTRWRDTFYDCIQKIEELEKQIDVARDVAEDTKSLGKELQNKINEKNLAEQKVEELQSQSFTKNKEVDLLRKKAQKAILKQADVVCATLSGSGHDLVAHSSLNFSTVIIDEAAQAVELDTIIPLRYGAKKCILVGDPNQLPPTVLSKKAASLNYSQSLFVRIQKNFSNQMCLLSIQYRMHPDISHFPSKKFYDSRLEDGDNMAEKTQQVWHVNPKFTQYRLFDVRGKERTSNTMSTYNLEEVEYLVNMVDELLNKFPDVNFTGRIGVITPYRSQLHELRRAFKVKYGKSFMSTIDIQTVDGFQGQEKDIIFFSCVKSYSKHGIGFLRDFRRLNVALTRARSSLLIIGNMETLKTDDLWGSLVDDALSRKLVESPHIDSEGRLITISRTSEKRMKNEEFVEPPSKKLANSEPSKEIRQRS
The following text describes a protein:
Function:
Scaffolding protein involved in icosahedric procapsid assembly. Coassembles with capsid protein(s) to form the procapsid. The scaffolding protein is found within the capsid as a series of concentric shells. During DNA packaging, the scaffolding protein molecules are released from the procapsid (By similarity).
Miscellaneous:
MISCELLANEOUS: When the gene is mutated the virus becomes resistant to the host CBASS CdnE-Cap15 system without altering the production of 3',2'-cGAMP or cabRNA by host CdnE; the host Cap15 effector protein seems to be activated but the virus still completes its replication cycle.
Subcellular Localization:
Note=Found in provirions but not in mature virions.
Domain:
In the 80alpha procapsid the C-terminal 21 residues of SP form a helix-and-hook motif that interacts extensively with the major capsid protein, especially with the N-arm (approximately residues 26-70 in the capsid protein).
Sequence:
MEENKLKFNLQFFADQSDDPDEPGGDGKKGNPDKKENDEGTEITFTPEQQKKVDEILERRVAHEKKKADEYAKEKAAEAAKEAAKLAKMNKDQKDEYEREQMEKELEQLRSEKQLNEMRSEARKMLSEAEVDSSDEVVNLVVTDTAEQTKSNVEAFSNAVKKAVNEAVKVNARQSPLTGGDSFNHSTKNKPQNLAEIARQKRIIKN
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCCWRAPDVLLGRARIHLLHKSVFQELSENLEGSLCRSQRTKWKKRPSCSSGLDTENTPNELIQQWSPPHKKALTTAKGKENEENLFVLARRPRKRRESSANLCWDSLPDELLLGIFSRLSLQDLLRTSRVCKRWHRLAFDESLWHSVDLVGKAQLDAELGQVLSAGVLRLRCPHTCIGQPSFKSTPSLRVQHLDFSNCTVETSVLEDVLSRCKHLQNLSLEGLVLSDNIIYSLAQNPEIIRLNLCGCSGFSPESLTEMLTACTRIEEMNVSWCDFSNLHIQAIASNIPSSVSQLNISGYRQNLTMEDVKAIVKRCPNITDLDLSDSVLVTTDSFPVLQQLSSLRHLGLSRCYQIHPASLIDFEKFLNLQTLEVFGLIQDSYLPILCKSLPHIQINTQPFSTVARPTSSSRKDRTLWGMHCRLVYKH
The following text describes a protein:
Function:
Baseplate protein that forms, together with gp54, the baseplate-tail tube junction. The tail tube first 2 annuli are formed by gp48 and gp54, which are in continuation of the spike complex. Involved in the tail assembly. Morphogenesis of the baseplate is completed by association of gp48 and gp54, which bind the upper part of the baseplate dome to form the platform for polymerization of the tail tube.
Subcellular Localization:
Virion. Note=Present in 6 copies in the baseplate.
Sequence:
MAIVKEITADLIKKSGEKISAGQSTKSEVGTKTYTAQFPTGRASGNDTTEDFQVTDLYKNGLLFTAYNMSSRDSGSLRSMRSNYSSSSSSILRTARNTISSTVSKLSNGLISNNNSGTISKSPIANILLPRSKSDVDTSSHRFNDVQESLISRGGGTATGVLSNIASTAVFGALESITQGIMADNNEQIYTTARSMYGGAENRTKVFTWDLTPRSTEDLMAIINIYQYFNYFSYGETGKSQYAAEIKGYLDDWYRSTLIEPLSPEDAAKNKTLFEKMTSSLTNVLVVSNPTVWMVKNFGATSKFDGKTEIFGPCQIQSIRFDKTPNGNFNGLAIAPNLPSTFTLEITMREIITLNRASLYAGTF
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MGKAFESGIVPFDESGLIEELLLALVGIHGDLFVDSSDIDRDDEKEEESWNLPGPSHCTVTISPELTWISEADRAVLGDLLRLGFHFKAVAAFVEREQSPWDPRHATRSPSVYRRALASGLTEMLDDYRCTVLTLQQELRLEAAPVLSTIKHRLWEYMDVLPALHALAAAQDEVSFNRLFPAADLINRLAAGTRSGLPAVRQALGRLLWHCNQVLMQQLAAWMLHGMLQDPNQEFFIQPRAQPPPPAAAATQQPQPQPQPQQQTQAQGGPQQQATREEDSAGASTSGRGADDEAAYREWHAGFQVNPRCLPLYVSGDLADTILFVGRAVRVLRRPGQGGGAGGGGGGGGAGAELLPLQDMMKFGQAFTALQSEPELSAPRLTMLVEGLRSHVARLLWRLLVGRAGLLPALAALKDYFLLGRGDFWQAFLAEARPLMAAPPRPGSVDADLALPFTRSAAKSSAEGDPLLAAFQLRYLGGKAEAEAAFTVKHSSAAHSQVPELDRAWDPLVLEVGLEWPLGLLLGREQLRRYNQLFALLLRLRRMQNQLDDAWKDLRVMDREMQRGTAPPVPHNRMRDLQDLRNHMAFVVSNLQIYIQTDVIEVNFSALENKIANCQDFSELERAHALFLNTLMVQSFLTVRTMCINLTEIFQDVAMLTQLVSRACCDPARLDFAAVSRLRSSFERHFLTLFGSISSQRMVESFRAPHLAQLVLRLNYNSFYSAKDMDAGGGRASVGVGTAGGRP
The following text describes a protein:
Function:
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
Subcellular Localization:
Nucleus.
Domain:
The JmjC domain mediates the demethylation activity.
Sequence:
MSEQVGQREAVDSPQATGVKTPPEPCPLCRETGPPQPPSITEEGKTNEDIDFIWVACNKCDEWYHSACLFLGDEKWRGTIPKEIISTVETNFGDEGAWTNWVEWIGKWYCAPCLARSTSPSNPRPPRHPLVATMKRASIQPKDIDQAGKPLKRSASTSAPLLKSNIKRPRTSTKGQETASPEIDMKSEREQQAESTAGTPASDAPQGRPKRKTAQIDYRNLNNSIATPTHQWLELIADPEKYGRTILDANYPALPGKLLTRAWLESQPLPGQPSSISPDLLPTRFWGPDREPLIVRPENGGFSSLGGHLPSKDLTVQDVANLVGPDRMVDVIDVSSQHSSQWTLQKWAEYIQSSSGNTSVRNPKVYNVISLEISGTELAKKVKPPKIVREIDWVDNFWRFNAGAGGKDVKEKGRGNDSREGSEIRKEGSHLTEGDNGGEIEEDLEGLKEKTNTPYPKVQLYCLMGMKGAWTDWHVDFAASSVYYTIHSGAKVFFFVKPTEQNLKAYAEWSGSYEKQQDTWLGDMVDEVRKVELHAGDTMIIPTGYIHAVYTPMDSIVFGGNFLHSYNVDTQLRLRQIEIDTKVPQRFRFPMFDRLCWYVAEKYCSDLRHLRAYRPRATTTPKPPHFRVLQCLSYLANFLVSQTGILEDPEAEDKARKLVHDRIPGDIVKDPEGLAKELKWRVERELGALGLLGEEASGVEAEEFKSNGTANGSVKIKGKEVSRKRDRLSKVFDKKAISRTWDFHPPAWSENRQSPQIETTTVQLPRPSTSSSDAISGSGPGASPGASANGGANENEQAELTTMLVKQTRKRMRELDDGTVIEESQETTFVEKKTIWGPKLDKEKISQPQGKVEEDMDIDH
The following text describes a protein:
Function:
Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
Sequence:
MTNKEEKSTFAEVFKQWEQSIHEEPELRKDQVVEGKIVSVDNDYVYVAIEGLKQEGRIPRGDFDEAPERGNYVSAIVKRKESQDSGCILSKKEADQRKGWEIVKEAFKNGYQVTGRLVNEIKGKGYIVNVEGVELFLPASQLSYKFKEGETFKNKELEFKIIELNDRTRSGVVSRKKLLDEVNEEKWDALLLKLKVGDKVKAIVSKIASFGVFCEVDGVTGLLRQRDISYKKYAPFKQYFQVGQEVELVILELDKENNKLALGLKQLYEDPWVWAERSLEKEMVIRGTVTSLTKFGAFVELKEGLEGLIHTSELAWSKKPPQPKDILKKGQEVEALVLDIDFKNRRLSLGLKQLQPNPWDQLGPEIRRGNVLEGVITGITKYGAFVEVENGIEGLIHISDITWDEKVANPTSQLKKGDTVRYMILDVNLDAQRISCGLKQLMENPYEIFRNEHPVGTIVEGKVKSIKEFGIFVEVAPGIEGLVHISEVPNGKEVNLTELYKSDEIVKTAVIKVDVKNKKISLSIKDFDKALEREEMSKYLKTSDAPSRESLGSFLNTSLR
The following text describes a protein:
Function:
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
Domain:
The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.
Sequence:
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDLKEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAFSDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDALPVLQATKWS
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MASTAAADSDPASRNPAPEKPTSRLKSADSGSTSASEQNAPKSPIQAASADTLDGESTEVSTPGTPGPSVLPPPLCAKYEDSFAYKTVRERLPVILTRVIDALFRDRMAIERRQGSEAREQQVVGRLSKLRSDMMTNKPLARITDDYADAALWNRAFEEWSELEPPRWFQAPWLYVECYLYRRIFEAFQLTTLLRDYDPFAQQKREALFESLSAIRSLTDFARKNAHSRASLETIRPVALRLIEVSLWGNRCDLSLSGGAASNPSGGALQETQSLRAKILCNQLPRLWAHLGRMRNRASGGIPTQLHLVMDNAGYEMVTDLCLLDYLQECGFISRACLHVKAMPWYVSDVMRRDLYKTLRQLRDLNHEPTSALAQRCLSRLESGAWAASEDPFWTLPHDYARMAALAPELYRSLQEADLVLFKGDLNYRKLVGDLRWEPSTPFEVALRGFLPTFLCALRTIKADTVAGVDADLAREVAHRSPDWMVTGEYALVQCAGRTLWSRDSEP
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MELRHLRYFVAVAEEGSLLNAAERRLNTSQPSLSRQIRDLEAEVGVQLLERQARGVTLTAAGRVFLDHARLALLQVEAATEGARQTAQPQRPVLSMGFLVGLEVMWLPQLLRILREEAPDVDVTLSTQSSPELALALMRGKLDIAFLRPEKDNEGVVFKILAKEPLIAVLPAEHRLASRKKIRPQDLAREIYVSSARTSPVLQEVIHNYASRVGITLKAKYEGENISSAMSLVASTGGISLVPLYAQNMLAPNVVARALEGGTPTVDLALGYNRTNPSPLLRRLLSRADELVANVQNQSIIRYVEAD
The following text describes a protein:
Function:
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MVEKHLLEFLEKLQFLISKNVKISHYGIENVKKICGVDIAYKGNLGFSVGVSMDINSGDYNYKSYVGEVNFPYIPGFLFMREAPLMIKAIEGLDCHLLLVDGHGIAHPRKSGIAAVIGVLLDFPTIGVAKSRLTGDLVNESEITYVYLNGEKVGVKFGRYFYSPGNKVDLQDCIELGKRGYPKVLKIADMLTKKIKKE
The following text describes a protein:
Function:
Required for regulated cell division, cell wall synthesis and the maintenance of cell shape.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=Localizes to poles and midcell sites.
Sequence:
MSEQVETRLTPRERLTRGLAYSAVGPVDVTRGLLELGVGLGLQSARSTAAGLRRRYREGRLAREVAAAQETLAQELTAAQDVVANLPQALQDARTQRRSKHHLWIFAGIAAAILAGGAVAFSIVRRSSRPEPSPRPPSVEVQPRS