lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Sequence:
MAYVALCKALYDYVAQAEDELNLTEDDHLYILESDDPEWWKAKLRRLDEHGTPIQDDSDDSTVGLVPANYVEEAEPIRLSRALYDYEAQTEEELSMAEDELLRVYESDGVWLLVKKQGNDPLSGGEGRLGYVPANYVDEAEAVDTGAAPAVEDEYTAADEDDEDDDDTDVTGSGAPIPQIHLPQTAQLGKGDNIKMWPVSALDSKKKKKKGTLGIGNASLFFASESDKTPVKKISILHIASHSLEKGKTLHLQLSPEAGLSESTLDFHAGSKDAANDIIRKIEVSKANALTAAAAPVPVPVPAPAPPAAAAAAASAAVPLPPPPPPAPPVASAAALPPPTRTTSATLPPPVRKNVSFQSQPAAEPEEAVEHGVAMYDFEAQGDDELTVTENEHLIILEKENDDWWKVRNDAGQEGVVPASYVEATDASAAAGASSGATAAAALAAQQEEEERLRREEEEAATVAEAERQREAVDRQREARERGEREEKERARREALKAQPVPAPPKLTQRPSTTDVSRAAKNVAIPQGRSAPERPKDGGSRSKPSPTNTRMWTDRTGAFKVEAEFLGFNQGKIRLHKMNGVVIEVAIEKMSNGDIAFLEDITGKKLNPTDEEIAASAARRRERERERQSSRPQSSAVAGMPREDRERERERRKEKEREQRRRESARSGPKRNVDWFEFFLAAGVDVDDCTRYASSFERDKIDETVLADLDPSTLRSIGLREGDIIRVTKFIDKKYRRDKSHSSLSSSRASGRANANTAADLERQIKADEELARKLQEQESSARRGDSVSPAPPQLFSGPDGTLKNNTRRGRPTPKSTSSSNVDAASLAAASESLARTATPPARTATASPAVAPKRTGSSLANGFDDDAWTPRPPSTKPTTPARPTVASPAPSTPAAPAAPPAPTPPPAAVAVASSAPPADPNSALFEKLAAMKAPSASVSPRPGVSPSPGSSFLGQSQMYNPNAPRGPFAPVPANQGLLQPLVPTQGTGQFVPTKTGMMGMQMTGMQPQLTGWGMQGMQGMQPQMTGFNNSMGSMSVMGGMGMQPQATGFGNGNGYGMNGSSPFTGGQISTQQTGLVGMGMQPQATGFNNFGQNAQQMMTQQTGFGMGSQQQGQQLQAEQDEKEKFKASNIFQQMKTGAFAKDPNAAPQSSEKYDALRPQPTGFQPGGVMPQFTGMGFGQSAQQQQQQQQQQYPYNNAYGGGFGGGF
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSALAARRATAAAASPKPEQPESSIEEVSVSGALTLPSPKRRKTRQTSPKPRSKARYSDDVPTSRQFFQATESLAEQRTGRFSPSAPDSDGGTSSSSVGDSDEDMAQEDEFEDRREVDGERDQRKVSVAANMSSSGPFKSLDLMPVDITSQFNPKDNVNFCRITEGQLASAEMNDGHPGPGVIVSLARNESLTIAGLFLLTPLQNTLSIYSTALSPSMSSFPVYAPTSHPLPVISPASTQAPGKESDKTLLLIRENRCGIDGLRNGAVPGFSNIWLEDNGPWGLRGVHPVVGSFPVPVYPYCTPPSWSHAISSLSSSDVNLQTPFVGLVKGPKRSGKSTFARALLNNLLRRFRKVAWLECDLGQGEFGSGAVVGLWILDKPALGPPFTHPLLPSRSHYLGTYTPLTCPDEYLVAIRHLIEHYKYELQYTSEYSALHTTVHDKISTHVPLVINTQGWMKGLGEELLNVIESMAQPTRVFSFESQSEEVYSGQGWTSTPPWQATQLPYDPAYPTTEPVETEVTQTYSLETAPVSALQARYTPADLRVLSAITYFHASLHPTQSVPVTWDISSPLVCTIPWEVELGIGKALEKVYLIGEGSEGVLEEDLPIALNGAIVALAEMLGSYEDEPTVYEQGRSPPPTDLVNILGLAVIRSLSSGNSVNPGLKLQLLTPLPPSYLSRARILIKSGALELPLPGMIDWRRGGINEEGMLGKGWEEIPFLDVGGLDVIGGERRRFRKNIMRKGM
The following text describes a protein:
Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTGIFCIFMWYLLLILYMGQIKGVFGTYEPITYKTGCSLWGIFFIISGISIIRATWYPSQRQLTCAMLENILCMILAIISMILTIVELSTFKSVSYRNYGQAKLGRQISRVLLSFYPLEVSMALTYSIFGCVGLCRKKEDARTADTEEVEDAF
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MVRFKNRYFLVELCWEQSPPSRAKPMTPKRLVEALRTAIIKYHGQFGLGSIQHTLNCKYLNMATGAAILRCAKDVEEILATTMPLLRRLGDYDCTLRTLSRAGTIASCRKALLSFNRTKLEHLTKALPPIKKAELEMQANIPLPDLS
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to 5'-pGpG. Cannot use cyclic AMP or cyclic GMP. Part of the RocSAR two-component regulatory signaling system (also known as the SadARS system), which regulates biofilm maturation, type III secretion and expression of the cup fimbrial-gene cluster. Negatively regulates the expression of cup genes by antagonizing the activity of RocA1.
Domain:
Contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The EAL domain contains a functional active site loop (loop 6), which plays crucial roles in stabilizing the overall protein structure and participating in catalysis, and also controls c-di-GMP and Mg(2+) ion binding. The response regulatory domain is involved in interaction with the Hpt domain of RocS1.
Sequence:
MNDLNVLVLEDEPFQRLVAVTALKKVVPGSILEAADGKEAVAILESCGHVDIAICDLQMSGMDGLAFLRHASLSGKVHSVILSSEVDPILRQATISMIECLGLNFLGDLGKPFSLERITALLTRYNARRQDLPRQIEVAELPSVADVVRGLDNGEFEAYYQPKVALDGGGLIGAEVLARWNHPHLGVLPPSHFLYVMETYNLVDKLFWQLFSQGLATRRKLAQLGQPINLAFNVHPSQLGSRALAENISALLTEFHLPPSSVMFEITETGLISAPASSLENLVRLRIMGCGLAMDDFGAGYSSLDRLCEFPFSQIKLDRTFVQKMKTQPRSCAVISSVVALAQALGISLVVEGVESDEQRVRLIELGCSIAQGYLFARPMPEQHFLDYCSGS
The following text describes a protein:
Function:
Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass type III membrane protein.
Sequence:
MCPQESSFQPSQFLLLVGVPVASVLLLAQCLRWHCPRRLLGACWTLNGQEEPVSQPTPQLENEVSRQHLPATLPEMVAFYQELHTPTQGQTMVRQLMHKLLVFSAREVDHRGGCLMLQDTGISLLIPPGAVAVGRQERVSLILVWDLSDAPSLSRAQGLVSPVVACGPHGASFLKPCTLTFKHCAEQPSHARTYSSNTTLLDAKVWRPLGRPGAHASRDECRIHLSHFSLYTCVLEAPVGREARKWLQLAVFCSPLVPGQSHLQLRIYFLNNTPCALQWALTNEQPHGGRLRGPCQLFDFNGARGDQCLKLTYISEGWENVDDSSCQLVPHLHIWHGKCPFRSFCFRRKAADENEDCSALTNEIIVTMHTFQDGLETKYMEILRFQASEEESWAAPPPVSQPPPCNRLPPELFEQLRMLLEPNSITGNDWRRLASHLGLCGMKIRFLSCQRSPAAAILELFEEQNGSLQELHYLMTVMERLDCASAIQNYLSGTHGGSPGPERGGARDNQGLELDEKL
The following text describes a protein:
Function:
Part of the excision complex necessary for the excision of prophage from the host genome by site-specific recombination at the att site.
Sequence:
MYLTLQEWNARQRRPRSLETVRRWVRECRIFPPPVKDGREYLFHESAVKVDLNRPVTGGLLKRIRNGKKAKS
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASSGSRSFRLAKFAFKVGIGVGAVYLTVVEGLWSNSTNNSGEVYNKVKATFLPQLNQAEKMAAEDRLSNLRDNVATEKLKEYWNSGVNSVFFGLKNSPEKINDIIKDSLK
The following text describes a protein:
Function:
Involved in ribosomal large subunit biogenesis (By similarity). Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III (By similarity). Also binds the transcribed 5S RNA's.
Subcellular Localization:
Nucleus.
Sequence:
MGEKALPVVYKRYICSFADCGASYNKNWKLRAHLCKHTGEKPFPCKEEGCDKGFTSLHHLTRHSITHTGEKNFKCDSDKCDLTFTTKANMKKHFNRFHNLQLCVYVCHFEGCDKAFKKHNQLKVHQFTHTQQLPYKCPHEGCDKSFSVPSCLKRHEKVHAGYPCKKDDSCLFVGKTWTLYLKHVKECHQEPVMCDECKRTFKHKDYLRNHKKTHKKERTVYCCPRDGCERSYTTEFNLQSHMQSFHEEQRPFACEHAECGKSFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLSGCAPPKSKEKSAAKATEKTGSVVKNKPSGTETKGSLVIEK
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MSCFVGAPELVNEGNPEYISWRNENENSDSSLDEVLTFSPDLGLSPVSSLSGSMGLLNCEHRITPRRRLKLSPDSQSPSPTEPTNQTQASMESKSFTGPLNLSTPRLDQSIVQSSESSYGARIRLKKSTRRLQMREREENASQPGIQKKSRMKLSDLFDRVEHIIEQPRQRTEKAKVKQLAKQGNDKRQGKKGPENKRPFVNGISPQFHAAEIEDEHLIGDFSKAYCLPLETGKHQDLKYISCTTLAQLLRGGYQDAVQQYHIVDCRYPYEYAGGHIKGAFNLHKEDHISNTFLKNDTLPKSTTLLIFHCEFSSERAPKLCRLLRNLDRNANRYPHLHYPELYILKGGYKEFFEKFKGLCEPQGYVNMLHKDFSDQLRQYHQNKTCHVRTVRKELFKPLYSNKCTVLKKDPAKD
The following text describes a protein:
Function:
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
Sequence:
MFKAAINAELLKDAIAALAVIVDEVRFKIKPEGISVKAVDPANVAMGIFELGSSAFDEYSADECEIGLDLNKITDLLGIADRNDTVRMGLEEGSNKLLIDVGGLSYTLSLLDPSTIRAEPRVPQLELPAKVVLNGADLRRAVKAAEKISDHMLMGVSGDTFYMEAKGDTDQVRLEMGRDQLIDLKAGEACSLFSLDYLTDIVKPTNKVNEVTLSLGRDFPILIDFEIANGAGRISYLLAPRIESD
The following text describes a protein:
Function:
Involved in the degradation of the pyridine ring of trigonelline (TG; N-methylnicotinate) into succinate and methylamine as carbon and nitrogen sources, respectively. Catalyzes the insertion of two oxygens, followed by a ring cleavage of trigonelline to yield (Z)-2-((N-methylformamido)methylene)-5-hydroxybutyrolactone (MFMB). It is able to use reduced FMN or FAD.
Sequence:
MRFSLFVHMERVSDQQTQKQLYDEMIELCQIADRGGMHAIWTGEHHAMNFTIAPNPFLNIADLANKTKHVRLGTGTVVAPFWHPIKLAGEAAMTDIISNGRLDIGIARGAYSFEYERMVPGMDAWSAGQRLREMIPAIKNLWKGDYEHNGEFWQFPKTTSAPQPLQQPNPPIWVAARDPNSHEFAVQNGCNVQVTPLHLGDEEVEKLMGHFNSACEKFQDIERPEIMLLRHTYVADSEEDAQVAANEMNVFYNYFGAWFKNEREINQGLIAPLSDEEIAAHPFYTPEAMRKNNVIGQAQEVIDRLKAYEAMGYDEYSFWIDTGMSFERKKASLERMINEVMPAFSESKVDRRHATISAVY
The following text describes a protein:
Function:
Suppresses host programmed cell death during infection by binding to Z.mays WAK17 isoform 2 and Z.mays LRR5, to prevent activation of Z.mays WAK17 isoform 1 and the downstream hypersensitive response.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cell septum. Cytoplasm. Secreted. Note=Present at the cell surface of invading hyphae growing intra- and intercellularly in the host, and in conidia. Present in septa of conidia. Present in the cytoplasm of germ tubes and in hyphae.
Domain:
The CFEM domain mediates interactions with host proteins.
Sequence:
MKLSVFTSVLLAGLVAAQQEKLPKCAQPCVDQYTTGGGVAGCGQLDIKCICSNKNFLSGIACCLEKECDAQGKETAVKYAKQICATAGVTDLPDDVTCDKSAASSGTASGTATGATTPTSSDSTNTASATGGSSTVEPNAGAREGAAGFIGVGMAMLLAL
The following text describes a protein:
Function:
Inhibitory receptor involved in the down-regulation of the immune response. Receptor for FN1. Receptor for integrin ITGAV/ITGB3. Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3. Also inhibits KITLG/SCF-mediated mast cell activation. Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells. Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells. Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation. Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury. Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation. Inhibits lysis by natural killer cells.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Sequence:
MIAMLTVLLYLGLILEPRTAVQAGHLPKPIIWAEPGSVIAAYTSVITWCQGSWEAQYYHLYKEKSVNPWDTQVPLETRNKAKFNIPSMTTSYAGIYKCYYESAAGFSEHSDAMELVMTGAYENPSLSVYPSSNVTSGVSISFSCSSSIVFGRFILIQEGKHGLSWTLDSQHQANQPSYATFVLDAVTPNHNGTFRCYGYFRNEPQVWSKPSNSLDLMISETKDQSSTPTEDGLETYQKILIGVLVSFLLLFFLLLFLILIGYQYGHKKKANASVKNTQSENNAELNSWNPQNEDPQGIVYAQVKPSRLQKDTACKETQDVTYAQLCIRTQEQNNS
The following text describes a protein:
Function:
Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.
Subcellular Localization:
Mitochondrion.
Sequence:
MLRIANVFKSGARAQLLPGRVSVQLAPVRHSSTGNLSSHMKDNMEADLVATHGQNHNNVHEYEDNRPERHHPDTIAARAAHMFSVPKHLDRAMADALQTKDMSPATLKRNVAQFYGGSDELVSKMETGRDNPLESALTVAAATLHQNYASAYAVLKEVRQKMPEGWTPNSVLDVGLGASAGMLAVNELFAEEENWNPDRKTAVILGPRVNTLLTKQFFDTQKHEDQGQNNFKDKVRNTRLQTGLPKNNLYKYDLIIANQQLDLMARQEDSTLEMLSARLVDLLSPGGVLVLVDRGNPNGYERIARAREVLIRPMGDTGPVKTPVPFGRTRKLHFSNDTEMKKLKQELGPEFDIEEQTMPVQDRIYLHIVAPCTHHGKCPFQQGQLRKQNTAKGSWCSFTQKLARPEYVMQLKRGKALAASWDPNVTRNKNKFSGGGRPGSSDLEVPSFSYLIIQRSTTPEVNIPNIQKWPRILKPPMKRKNHVIMNICGPEGGLHSWTVTKSQGKQEYLDARKALQRDQWALDAKVKTPVRKNYQMALEDEKISRNPSAQEKINKVTALSTTQRRDLVKAERRKQIKRARREARLGGQLEPKKDDEEDDQE
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Sequence:
MFSPSVYSEIIATLPPSVRLVAVTKTKAIADIEAAYGAGIRDFAESRIQEALPKIEALANYQDINWHFIGRLQSNKARKVVENFTYIHSVDNLAIAVKLDRIAEELNKFPQGLLQIKLLPDENKSGWTREELKLDLPQLELLKNLKICGLMTILPLGLSPGDRQLTFGELKNLATAINQQSSLSLTELSMGMSGDYPEAIAAGATMIRLGTILFGDRL
The following text describes a protein:
Function:
Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence.
Subcellular Localization:
Nucleus.
Sequence:
MSAQFITPKKRPHSPLDSNELLPSFEDPQDMINAVVSTLSAPEEKTNVSIAYANEKNQATEIQAYAKIAGKDWTFYVKSLAVSIGRNIELSAPSNTNITTPLIDIDLGPAKVVSRSHAAITYNLDLRCWELKVLGRNGARIDGQKVNVDSPNVNALHSGAILDIGGTQMMFILPDAPAVVAPKMLEKCLLRYKEQQQQQNKRISSGPGIGGSTSFQMFDKAHLTHSPSSISANSLQSNLDQDLSKEEAKDIKPPYSYATMITQAILSNPQGVMSLSEIYNWIADHYAYYKYSKTGWQNSIRHNLSLNKAFEKVPRRPNEPGKGMKWQISESYKEEFLNKISDGTISKTRRGSSVSRQLSLHLATHNQLPESHKYTMDQQIHNGTAASIPQQQKQQQQQQKRPPQQQNSQPHLSQPHYTIPSNPMQTNSMGYIPQSNIYNMSNSDRRYTPYQQSQNPLMYQHQQQHIGQTYNQLGRPQGQLGQPMMQPQQQSYTSSNIKTEPSSPKRNPSISNNTPKMAKGTVSTESHSRSTSYTTTQLHEMSNFNSSANDSTSTAPTASTTTNGDIGLNFASPKKITALEAYTPERGSKGNPSGTNNNNNTNNTNTNTTNNNNGKNTAGGPNTNQSSPAFWNFVQFSTPNGQSPVRKSSEEVGNNSPTLNRKIKRERENDETNSPFKKKQRTEMIDS
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MTSKVGAVATKTYREKLGPEILEVFDKSYKSFTDVQVLAGTHLLNLSDVVVESPTGSGKTLAFVLPMMRMIQNARLQPNEIGALILSPSRELCSQIVNVIKPFAEKMKLNVETVTGGQKVDKNIKMFKNKDINILVATPGRLFQIIQHEKTMIARAMKGVQLLVIDEADRFNEIQFEDHMREILSCIPKQRRTGLFSATQVKEEDDLMVFGLRNAKQVKVSQERNSAAPSTLKNYFVECPADEKTSVCLEFIRQRTDKKVLIFFPSCNSVRYFHKIFERCLTKRPLFAVHGKCSNPHRAAQIKAFSESTNGVMISTDVMARGIDITDIDWVIQYDLPKHSSWFVHRAGRTARCGRDGNALILIATEQLAYVSFLDNHEKVKLEEVKVPTSTSRKAEELRQKMIKIQVSDRAILELGTRAFVSHIESYAKHDCHLICSLDDLNVVGLANSYALLRLPKMRELAQRKDLNQFDRSDIETSEIKYADPKLEANRDTVMKEKHEKKIETLAAKEKKRREKEARKMKRAGGRFKSRATGANAEEKRAKKRKSEEEDDAQNDIRLLKKIKRGKLSKKEIKDVL
The following text describes a protein:
Function:
Digests double-stranded RNA. Converts long double-stranded RNAs into short oligonucleotides, leaving 5'-phosphates on their cleavage products. Probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development.
Sequence:
MGRFKRHHEGDSDSSSSASDSLSRGRRSLGHKRSSHIKNRQYYILEKKIRKLMFAMKALLEETKHSTKDDVNLVIPGSTWSHIEGVYEMLKSRHDRQNEPVIEEPSSHPKNQKNQENNEPTSEEFEEGEYPPPLPPLRSEKLKEQVFMHISRAYEIYPNQSNPNELLDIHNERLEFLGDSFFNLFTTRIIFSKFPQMDEGSLSKLRAKFVGNESADKFARLYGFDKTLVLSYSAEKDQLRKSQKVIADTFEAYLGALILDGQEETAFQWVSRLLQPKIANITVQRPIDKLAKSKLFHKYSTLGHIEYRWVDGAGGSAEGYVIACIFNGKEVARAWGANQKDAGSRAAMQALEVLAKDYSKFAR
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSENTRCSNVQVEGEVDLGTSNIFQPHVRIIQEQNAGPIVIGTNNIFEECVTIINKSPGLMKIGNNNLFNTGCCVYAGLIGDYCTISPRAIVGQGSCIEDNCIIGSKCEIPPNQHISKGTLIYGRNNSFRKIASTVGFVAPLHSKHIDYLVQVLPKYHPTRK
The following text describes a protein:
Function:
Serine/threonine haspin-like protein kinase involved in cell cycle regulation. Acts in chromosomal passenger complex (CPC) targeting to centromeres by phosphorylating histone H3 at 'Thr3' (H3T3ph).
Subcellular Localization:
Cytoplasm. Chromosome.
Sequence:
MESRSKVKTYGKNRRYINKDIEIWASLDERPCALKPRNIENFNNQERSDLEHIHSKPKKDSLLSWNILLKKGSYKENELLAKRNQNLVPTVIIPASPRDNASKSVVSKKEVVNLSSSVALSGKPANNSKLDPLHRLLQIVAQEDALPFSQFVKSQTFEIQKIGEASYSEVYQASNADDVPVVWKVIPFGEDGQAQYADVLNEVQISQWIKVDGFANLHQVVVVKGTYPSLLLEEWDRYLMQNGSENDRPDSYSSTQLYCVLCLDHSGTDLEHFELRSWRECWSVFYETLKILSLVETRYEFEHRDLHWGNILIRKADRSEEEVSFLLNEISLDDIESVDFPGSQDKADDFDNILQVTLIDFTLARASYSQGIISYNEFNDPDLFNGVDDYQFDIYRLMSRVTKGRWAQFFPITNVLWLHYLIHQLLHKKNLSSPLTETETLMRSRLKQIFRLIDPVKTMQFQQAEDSIRSKSTVTSATSLLNWVRQKY
The following text describes a protein:
Function:
Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
Subcellular Localization:
Golgi apparatus. Golgi apparatus, trans-Golgi network membrane.
Sequence:
MAEESPKNSAAEIPVTSNGEVGDAHEHGYNRDLKHSLPSGLGLSETQITSHGFDSTKEGVTEAGASQGSSAPPLPCVLSPSRVAASQLTQHAGGQRTHTKGGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQKQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYENARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQIHKEKYDKMRSDVSVKLKFLEENKVKVLRNQLALFHSAVAAYFAGNQKQLEQTLKQFHVKLKTPGVDAPSWLEEQ
The following text describes a protein:
Function:
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MVFLQGECTLLREMADAVVEFLLLNLKQLLLYHVDLLSGVKDEVESLHRELSLMKAFLKDSREKRSEYEYVRELVSQITIVAYEAEDIIDTFVTNAAMQKARSTVRRAFHVFDHSSKLRNVAKEIESIKVKVKEIYDKKMFGIQSLHGGESSHRSPPQKRVPMVEEENVVGFDDEARKISSRLTNGSEELEIISIVGMGGLGKTTLAKKAWDDLQMAFPKTATGSRILLTTRNTEVALHANPEGLPHHLRFLTHEESWELLSKKVFRKGICPLELEDIGLQIAKKCYGLPLAIVVVSGLLLKKEKTRDWWKKIANDVSSYVARDPKQCMDVLALSYKHLPDHLKVCFIYFGVFPEDFEIPVWKLLRLWTSEGFVQKMGQECLEDTAEEYLEDLVDRNLVLVAKKRASGRIKTCRIHDMLRDLSVKMGSEEKFLEVFKESAQNHSLSPISKYHRRLCVHSHFLDFITSRPFGPNVRSFLCFASEEMELLREHTSFLHEAFRLVRVLDLKYINFPRFPTEIVQLVHLRYIALSGNFRVLPASISKLWNLETLIVGTKSRELDIQVDIWKMSQFKHLYTSGLSCLRGPPAKTRKDNADPFVRRNIQTISTVLPDCCKENILARTPGLRKLGIRGKLATLVATNGDSSLFDNLAKLDNLETLKLLNDTFPLPPSQCQIPGLPQSYKFPPNLKKLTLSDTFLDWSHISTLGMLPNLEVLKLKDYAFKGTQWEPLDGGFRLLRVLHIGRTNLEHWNASGHHFPRLQQVFLKHCSSLNEIPFGLVEVSSLQNIELFWPTPAAAASARIIQQEKQEGDIKDNVFKLVIYPPDI
The following text describes a protein:
Function:
Enzyme hydrolyzing GTP.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSSTAILKASGDVAINYQQYIYPIIINKLSTLNYTIKNKKYYSQYKYSIQFQNEFQKNLKIYNNSNNNNNNNNNNKINKNNNNNNNNISKFFIQNNNIDKKVLRHFYSSTKLNYAKQQQQLFKNNETFNETVGASLLPIINKLQENAALIGSEITLPQIIVVGSQSSGKSSVLENLVGRDFLPRGSGLVTRRPLVLQLYQTTTTSRNNVNENEDEDEDDNYYDNDNDDNSLEEWGEFGHTGTNRFNFQEIKEEIERETERIAGPNKDISSEPIVLKIYSPKVVPLTLVDLPGLTRVAIEDQPPDIEEKIKSMIIDYISNPNSIILAITPANQDIVTSDALKLAQQVDPLGKRTIGVLTKLDLMDKGTDAIDILLGNSIPLSLGFVGVVNRSQQDINNRKPIEQMLADEWKWFDQHPVYHRITNQLGTKYLAQKCNKILTKHIRDTFPSVKNQIRQLIKKYESDLEKYGEPIPLRSAEKSRLLLDILNEFSRKYRADLDGTNEELILNEFNGGARIRYIFSKAFQSTTAAAATTSTDNSGGGEPFGWLSDQQLKIALRNSGSTMFIPQKIFDSLIRKQLERVREPLIQTSEIILDELIRILTQADYSHVLSRFPILKERIVEVSNNALRKLVKECNQSISQMVDAEMSFINTNHPNYLYQLNNLLFSSSSSSFVVPQGAFQSTSSTSSSPTSSSSSLPLPQNSNPYNDALNPYNIDRSYPIDNQIKQQQQQQQQQQQQSYQQQQQQQQKQQSGFLSRIFGSSSSPPSPPSPPQPKQQQSHEIQIQQQQQQQQQQHLKKQNLIFDDKFKLEQYGLNDITEDEKKQIYLLRRLLLAYNDIAQFNLQQNTMKLVSLLLIDKSKDILQKELIDSLYDQSSVDQLLRENELVVAKRNECIYKLDLLKKAKKSLSQSENSDLLHLY
The following text describes a protein:
Function:
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Mainly located in the perinuclear region of unstimulated primary T-cells; upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity).
Sequence:
MASPAIGQRPYPLLLDPEPPRYLQSLGGTEPPPPARPRRCIPTALISASGASEGRGSRRNARGDPEPTPRDCRHARPVRPGLQQRLRRRPGSHRPRDVRSIFEQPQDPRVLAERGEGHRFAELALRGGPGWCDLCGREVLRQALRCANCKFTCHPECRSLIQLDCRQKEGPALDRQSPESTLTPTFNKNVCKAVEETQHPPTIQEIKQKIDSYNSREKHCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNPAATTDKRTSFYLPLDAIKQLHISSSTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADCPLYLRLLAGPDTDVLSFVLKENETGDVEWDAFSIPELQNFLTILEKEEQDKIHQLQKKYNKFRQKLEEALRESQGKPG
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MYILKKLTFIGFLSACFINCQGFVNSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQNQKDDLAEAWYNLSLTRFDNIIEKYQVHKAWALLLAKNKQLTEAFQHFENKPEGIVASNEVIHFEGVLATTQNCTAVVQKPSKKLHCRYNTSTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSDFGLSESVSGLKSEVRTSKDSHIVDAKTLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDFHEYTNTTRLKQGDRIATVLFYLREVDSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTPCMKDSNLRPPQKE
The following text describes a protein:
Function:
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCSGIIQCLSAEDCVDWLQAIATNISNLAKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKHCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQATASAAASSATTSKAKYTT
The following text describes a protein:
Function:
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
Sequence:
MDKVQFNTQMVNMRKTVKRAKVQLIHHLTRQIMVVRKKKGSGQQLVKNERRAGRLVKEIEVIKDLPCDEVTMSAVINKQSLQAVLDNGNSTAEQRGTARLIHHKVISQQIATFKDLVTDDLLEIGKRKEKLLSRTEEGNTKKADRRRSESSNEEEEDSLEEADNASEASDNDGDETKASPFLTMDTGRSKKSESTSLSEQNQQLREQMESRHKKSGFFTTAQSKEDKLQGESDDDEEEESEEMDDDEEEEDDVESIEDMDDDIDDMGENFNSEFRELSAEIKKGKYSGHVEKERKKSKGLDSLFVGRLSGKGHDSGDKTIKGRKNRPGQTERHKINIKKQINVLRRPSGKEPREGSRHVALVDLPSLDAREKQPSKRKVIPGINALYEKPKTGDSSNEKVLPSQRSMVSKRGRGGARGGGRGGGAGGGGRSLMMASAQAPEALHPSWEAKKKKKEQESKILPFEGKKITFDD