lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKASKETKRLFVGGLGQNISEGDLQNQFNRFGEVSDVEIITRKDDQGNPQKVFAYVNIRIAEADLKKCMSVLNKTKWKGGTLQIQLAKESFLHRLAQEREEAKAAKEKPTAVNTNLLEKMGVVDFHVKAVPGTEVPGHKNWVVSKFGRVLPVLHLKNRHKRKIIKYDPSKYCHNLKKIGEDFTNANPISNLTWELEGGNDPISKKRRGEFSDFHSPPKKIIKVQKNEGSTASPAVRPKPSRITERPWLKQQAAQKTPDGPITPKLSYISDSESQILKNVFFQTSGLETTKNRNSMSDDDIDSEDELRLTIAREENLEKSTWPLVNESENDPFEVVRDDFKSDSHKFHTSIGLGLKNNISSLDSEDNVMGNDYDSDSGDTDEIITRNKNAGKIKNSIALSQMEKSIHKKTSSKNRKKCDLSDSIKEQKRKNNVEIAVSHRVKMPSRKSLADSSGSEDADSASESAESGGDKEYHTMMNCVHVTLTLADLEQLASSNQEAPKEDTESNGQETTAKRDRASKSHRTLGGLHKGHQCINPEEIVASLLEGKEDTCGKQKPREDLKPKFQAFKGVGCLYRKESVKESSKESVASNNKDHNSLILDAPRSISMEKWSLYANDLSGEPTSFQHAKKANDSNKIQPQKKQSTFESQEHEVVSPSNSGKRSRNPTSSLLPVEDKKSLSVAAKTPRRGFDEDSCHRTGKSGDDSENRPILSSRKAPEKSEFSRRDTQENKTNFPLPFNSSSDVNAKDKHAEDNQKRLAALEARQKAKGIQKKLVHNALANLDGHPEDKPTHIIFGSNSESETEETSTQEQSQPEEEPVKESMGRASGKLFDSSDDESGSEDDSNRFKIKPQFEGRAGQKLMDLQSHFGTDDRFRMDSRFLESDSEEEQEDTSETKTAAEEEIAAEKLKALNIVQSVLHINVSSSTSKGSVAAKKFKDVIHYDPTRHDHATYERKKDDKPKESKAKRKKKREEAEKLPEVSKEMYYNISVDLKQIFQTAKDTSEKRDSTAWNEDSGGEKAEEAQDPAALIMEDEQPEGFTFSFFDSDAKDVKEETYRVETVKPGKISWQGDPRFQDSSSEEEDVTEETDDKKPNPEEVSLPEKETTRFFFFSKNDERLHGSDLFWRGVGNNISRNAWEARINNLRMDCRKKHKDAKRRLKPK
The following text describes a protein:
Function:
Protein kinase that participates in the induction of vulva and has a role in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Positively regulates lifespan upstream of mek-2 and mpk-1.
Sequence:
MSRINLKKSSAATTPTSPHCPSPRLISLPRCASSSIDRKDQGSPMASPSTPLYPKHSDSLHSLSGHDHSGVGTSDKEPPKFKYKMIMVHLPFDQHSRVEVRPGETARDAISKLLKKRNITPQLCQVNTSPDSKTEAIDLSKTMEEIALHLPDNELWVHSEYLNTVSSIKHAIVRRTFIPPKSCDVCNNPIWMMGFRCEFCQFKFHQRCSSFAPLYCDLLQSVPKNEDLVKQLVGIASENDGPDRSVAEIVLAGLAPTYGQSPAATPDSSHPDLTSIKRTGGVKRHPLAVSPQAETAQLSPAGPYPRDRSSSAPNINAINDEATVQHNQRILDALEAKRLEEESKDKTGSLLSTQARRPHCYSGHILSGSRMNRLHPLVDCTPLGSNSPSSTCSSPPGGLMGPTLLGQSSSVSGSTTSSLVAAHLHTLPLTPPQSAPPQKISPGFFRNRSRSPGERIEAQRPRPPQKPQHEDWEILPNEFVIHYKVGSGSFGTVYRGEFFGTVAIKKLNVVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMGWVREPEIAIITQWCEGSSLYRHIHVQEPRVEFEMSAVIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGVCMYEILSSHLPYSNINNRDQILFMVGRGYLKPDRSKIRTDTPKSLMKLYDNCIMFDRNERPVFGEVLERLRDIILPKLTRSQSAPNVLHYDSQYSVMDAVMRSQMVSSSYIPPSTAKTPQSAAAAAAANKKAYYNVYGLI
The following text describes a protein:
Function:
Seems to be required for the assembly of the photosystem I complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MERWWFNSMLFKKEFERRCGLNKSMGSLGPIENTSEDPNRKVKNIPSCSNVDYLFGVKDIRNFISDDTFVVSDRNGDSYSIYFDIENQIFEIDNDHSFLSELESSFYSYRNSSYLNNGFRGEDPYYNSYMYDTQYSWNNHINSCIDNYLQSQICIDTSIISGSENYSDSYIYRAVCGGESKNSSENEGSSIQTRTKGSDLTIRESSNGSDLTIGSDLTIGSDLTNGSDLTIRESSNDLEVTQKYRHLWVQCENCYGLNYKKFFKSKMNICEQCGYHLKMSSSDRIELLVDPGTWDPMDEDMVSLDPIEFHSEEEPYKDRIDSYQRKTGLTEAVQTGIGQINGIPVAIGVMDFQFMGGSMGSVVGEKITRLIEHAANQILPLIIVCASGGARMQEGSLSLMQMAKISSALYDYQLNKKLFYVSILTSPTTGGVTASFGMLGDIIIAEPNAYIAFAGSGYNRFDIKEGIVCSFRWGFPGKNRRIFLRFLIKDIQSVRIEVKEGNYARRVLYMDIRGQGSIPLSRTDENLTPREIEQKAAELAYFFHVPIERGYENPREATGHIVCANCHLANKPVEIEVPQAVLPDTVFEAVVRIPYDMQLKQFDGSYELAVFDPSDPVLDPIWR
The following text describes a protein:
Function:
Probable GTP-binding protein that may be involved in cell development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGDACFSTQLIDGDGVFNVSGLENFMKDARLGECGLSYAVVSIMGPQSSGKSTLLNHLFGTNFREMDAFRGRSQTTKGIWLAKAQNIEPCTLVMDLEGTDGRERGEDDTAFEKQSALFALAVSDIVLINMWCHDIGREQAANKPLLKTVFQVMMRLFSPRKTTLLFVIRDKSRTPLENLEPILREDIQKIWDAVPKPHAHKETPLSEFFDVQVVALSSYEEKEELFKQQVSDLRDRFQYSIAPGGLAGDRRGVVPASGFSFSSQQFWKVIKENKDLDLPAHKVMVATVRCEEIGNEKVGSFTSDEEWQQLEEAVQHDFVPGFGKKISSLLDRCLSEYDMEAIYFDEGVRSSKRQQLESKLLQLVNPAYQSLLGHLRTRTLEAFNESFDKALEKEGFAAAARNCTQTFLEKFDKGSEDAAIQQVNWDTSKVKDKLRRDIEAHVASVRAAKLSELCAKYEAQLTKALAEPVESLLDSASEDTWPAIRKLLQRETKTAVSGLQSAVSAFELDEATEKELLVKLEKHGRSVVESKAKEEAGRVLIRMKDRFSMLFSRDADSMPRVWTGKEDIKAITKTARSASMKLLSTMAAIRLEEDGDNIENTLSVALVDTSKPGTTDRSIQLTDPLASSSWERVGEEKTLITPVQCKNLWRQFKAETEYTVTQALAAQEANKRNNNWLPPPWALAAMAILGFNEFMTLLRNPLYLFAIFVIYLVGKAIWVQSEIGREFQHGFLPAILSLSTKFVPTVMNILKRLADEGQAPAAAPERQREMELQPKPTRNGSSYTNATSAGSSSVTTSEIGPEYSSPVAQ
The following text describes a protein:
Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MACQTGIRANAALRNALNLGKQAKLRLIKIVVNNEEMTPNYEFAGTANWRDDWRACLPDCVDAYEPCFILFRLNTITEWVLITFVDDRAPVREKMLLAATCATFKSEFGQCYIEHEKHVTDLKDLTLNAFEAWLKAKTELGPMSEVERELHNAQQERAAIAHAGPQHMKGVAFPVDRNAEEALRQLASQKLSFVQLSVDTLNEAIKLEGTLESLEPSQLASKVPRDKPRYTFYNFDHTWEGVPQQCTLFIYSLPSSGSSIKERMLYSSCKGPFLSAAQNQYGVVITNKMEVDARDDLSEKALLEVIHPLPVEAPKQFSRPAPPRAGPRRITKV
The following text describes a protein:
Function:
Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular Localization:
Cytoplasmic vesicle. Secreted.
Sequence:
MMNSTLMIFKIVLLLTLVSWINILQARPLTTSSTGRTTTLMTRLKLQDEEEDSSECWDSLFELQACTGEIVLFFVNGETYLGQNCCGAIRIIERQCWPSMLGSLGFTSEEGDILHGYCDASESPSTPNLAP
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSNSKVLPHTNALNVENADISEIDESSLINYGDNNEQTDTTRTRNTQPQVKNHFIINQTILFVYISFFSIIGCFLRIGIDLVFSAELAHIESSTQIIVQSYFSNIFGCFLLGFIHRLNLKPGPLVTGLTTGLCGCLTTYSKWNQQISLLLVGMVTTTSQSQLSAICVITIGMLTYSCSYITGEDFSRWVVSRNVIKRQLSKKASTICHCCITMSLVIIITVLLALIFIYQSKSYVILTLCLSGLLAPLGASMRYVISMVTPKFDFKRKVVVLNRLPTGTLLANVLGSIAIAVCYVIKLHTHNTTTMVYLDGIQTGFLACLTTVSSFIGEVIQLRRNKPGNTGQESGNTASYAYVVITITLCLFCGSMVNLTSVNAYHELGLLSDLANMTNTGL
The following text describes a protein:
Function:
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
Sequence:
MSSQVTYQSTRGGSSNFSFEDAVLKGLANDGGLFIPSEIPKLPEGWKEKWSSLSFPELAYEIMSLYIPRSEISAEELKDLAARSYATFRHPETTPLKKLNNGINVLELFHGPTFAFKDVALQFLGNLFEFFLTRKNGDKPEEERDHLTVVGATSGDTGSAAIYGLRGKKDVSVFILFPEGRVSPVQEAQMTTVTDPNVHCVTVAGVFDDCQDLVKQVFGDAEFNRKHHVGAVNSINWARILAQITYYFYAYLSLYKQNKDVKVRFVVPTGNFGDILAGYYAKEMGLPTEKLVIATNENDILDRFFHTGRYEKADTSKGPVTGPVCAKETYSPAMDILVSSNFERYLWYLARQQVAPNHTDSEACEILAKWMNEFKTNGSVAVRPEVLDAARKDFVSERVDNETTIATIKKVYETDKYVLDPHTAVGVEATTRRMKEAGAEGTTFVSLSTAHPAKFDAAVNLALSSFEGYNFETQVMPREFHGLKDAERRVIFSGAPRIEVIKQIVEINLEREKKMTV
The following text describes a protein:
Function:
Involved in ribosome biogenesis and cell polarity. Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
METTEGKNDLRAKLAEKIQTFRSQRKATEKVDRALLLQRRKEKAKARAEAKKLAKKESKAKQESKVAAYDTGNSSDNIADEENDNHKSTITYGTLIVGDDKFSNGKLKVAGKKRGPTDVFGALKHLEAKKRRIESMDEEKRRKIEESDKWHRVLLQAEGKKLKDNEQLLKKSIRRKEKEKKKSSDAWKERKDNEKKAMLMRQQRREENLKKRRESKKSKKGKAPKKKKPSKKK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MPHKAKNLFSLARGKVRASWNPRNLYNLYKKTDFLRDEKTLFQKKWASKRELRAYHGEHIREGTLTTQIPKKLQGVVLPLGDDVTSEGIMANRFDDQMLEFDAEGNKKLKTPFAMQTFVHLEKRLDFAVFRSMFAASIRQAGQFIRQGNVTVNGVKIKHASYTLKPGDLISVKPEKVLFAAGKAKPSVEEAVKIDNRQIKKYNQYIKKCNDDPEKMWNVRLDKIKKREAGKLMDPKTQMQLQKANEVAFQAMLARLRELCSAAIFEDLITGRDEFLKTQTDDTKVLGEKLLKLIDQQFPANGADPVAPTAEGFLTPEAVIELLNERSTKLAQEAETKAEAAVEGSAEQKKAETVRSNANHLIEQRNKNMAGIGSKKLEFAIHPKDINHVSSIESPHTKNIVSSCLISRKAEFAGVEERKVVYAARCLIQEMKTNVADSIHDSYNEHQQKLLNPSVQDTEVNPRWLQLLGPLREKIDAAEAAENEAEVAQEFPWQKKHLYGRQDISKPYFTPWRFRPFISPSVIYPHHIEVDFTTCSAVYLRDPVARPGMSEVISPFPLINHEFANLYYIKK
The following text describes a protein:
Function:
Pore-forming subunit of a voltage-gated ion channel. Permeable to monovalent cations, divalent cations and anions with selectivity Ca(2+) > Mg(2+) > Na(+) = K(+) > Cl(-). Acts both as a voltage-gated and calcium-activated ion channel. Required for normal locomotion.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTTSINSVVTVFQNVFTNHGSTLLNGILIATTVGGQSLVRKLTFSCPCAYPLNIYHSLVFMFGPTAALLLIGITVNSTTWKLAHGFFFRVRDTRHSWKTTCVSWIEVLIQSSVAPIAWLFVVFLDGGYYRCYRSHEFCLISDAILCKNSTILNSYASTSSFNKISDNGKYCPPCICVPNPTDASYLEAESQIYAWGLLLFSGVAAFLVITCNRMCDKYTLVQRQYVETYKNVETQKFDAVAKEHASQLAEHNARAFFGQKDWTKRDWDWVSGIPEVNNPLFARLRLIAAEKTQQTMYTPLQLWNDNKGYRIPQPDLQLTQIIVDETKED
The following text describes a protein:
Function:
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Co-expressed with yemalpha.
Sequence:
MPRHSRAKRAPRPSANNSKSPNDDDTAFRSPEPEDGTDYGLEFTTSQLTLQDNNRRSSTLRRDAGRRQPAARDSSTSGEEEDQENRYPTTRSPQTRRMTVQQESKTRAAGPVAAQNQTRRRKAANPMSRAKRMDREIRRLQHHPGTLIPKLPFSRLVREFIVKYSDDEPLRVTEGALLAMQESCEMYLTQRLADSYMLTKHRNRVTLEVRDMALMAYICDRGRQF
The following text describes a protein:
Function:
S-adenosyl-L-methionine (SAM)-dependent methyltransferase (MTase) which mediates the methylesterification of the pectin homogalacturonan (HG) and thus regulates cell wall biosynthesis, at least in suspension-cultured cells.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MGHVNLPASKRGNPRQWRLLDIVTAAFFGIVLLFFILLFTPLGDSMAASGRQTLLLSTASDPRQRQRLVTLVEAGQHLQPIEYCPAEAVAHMPCEDPRRNSQLSREMNFYRERHCPLPEETPLCLIPPPSGYKIPVPWPESLHKIWHANMPYNKIADRKGHQGWMKREGEYFTFPGGGTMFPGGAGQYIEKLAQYIPLNGGTLRTALDMGCGVASFGGTLLSQGILALSFAPRDSHKSQIQFALERGVPAFVAMLGTRRLPFPAYSFDLMHCSRCLIPFTAYNATYFIEVDRLLRPGGYLVISGPPVQWPKQDKEWADLQAVARALCYELIAVDGNTVIWKKPVGDSCLPSQNEFGLELCDESVPPSDAWYFKLKRCVTRPSSVKGEHALGTISKWPERLTKVPSRAIVMKNGLDVFEADARRWARRVAYYRDSLNLKLKSPTVRNVMDMNAFFGGFAATLASDPVWVMNVIPARKPLTLDVIYDRGLIGVYHDWCEPFSTYPRTYDFIHVSGIESLIKRQDSSKSRCSLVDLMVEMDRILRPEGKVVIRDSPEVLDKVARMAHAVRWSSSIHEKEPESHGREKILIATKSLWKLPSNSH
The following text describes a protein:
Function:
Essential protein required for proper condensation of mitotic chromosomes and progression through mitosis. Binds to specific polytene chromosome sites, many of which are shared with the posterior sex combs (Psc) protein. Involved in maintaining Abd-B repression outside its normal expression domain.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome.
Sequence:
MTMAACYANYDMSSLSHGMSALSALQQQQQQQQQQHSQTQQQHHHQQQQQHMYHAAVAAHQQQLLQQQQQQQHHRHHHQPANTSSSSNSRHSHAAATQTQVAAAVANSRQQQQQQQQQQQQQQQQQTASSNSNAAPAPSPQKDYSIPLHVDCSVEYELPNQPKPPAGQRVEPLLMIHPCYFRKMESQRRSPFVNNMHATARAVSSSSLSSGAALGGGGSGAAVATAPSSSAARRGARAATSAQQQQQQQQRYQQQQQQLRQQHQQMSQMSQQAHYPQQQSSLVRQHQQQQQQQQQQQRASSNQSQRQSQSQSQSQSHAANSAAAAAAQASIAAAAAGQWDQLAALAARTALTPHHMLHPHSHYAAKGSGGGAGGGKRDAMISGSYGQTAVASGKLQQSQVQQQQPQQQQQHCLPPPPWDATSMLMDRSPMATVPSNYQAGPDTNPMRLYSATPTAGAASGGSASVGGGGAVSGAGATGAVNTATDKLSGKYRQYLRSQRMHPYAAAASLNLAAAAAAAGQTSFVPFSSAATAVAATPTFQHLPQISCYNV
The following text describes a protein:
Function:
Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component.
Subcellular Localization:
Periplasm.
Domain:
Contains an N-terminal Cup-like domain and a C-terminal peptidase domain, separated by a flexible linker. Structural modeling identifies 2 potential metal-binding sites in the Cup-like domain, with site I binding Cu(2+) and site II favoring Fe(3+). The peptidase domain may also contain an iron-binding site.
Sequence:
MTINFRRNALQLSVAALFSSAFMANAADVPQVKVTVTDKQCEPMTITVNAGKTQFIIQNHSQKALEWEILKGVMVVEERENIAPGFSQKMTANLQPGEYDMTCGLLTNPKGKLIVKGEATADAAQSDALLSLGGAITAYKAYVMAETTQLVTDTKAFTDAIKAGDIEKAKALYAPTRQHYERIEPIAELFSDLDGSIDAREDDYEQKAADPKFTGFHRLEKALFGDNTTKGMDQYAEQLYTDVVDLQKRISELAFPPSKVVGGAAGLIEEVAASKISGEEDRYSHTDLWDFQANVEGSQKIVDLLRPQLQKANPELLAKVDANFKKVDTILAKYRTKDGFETYDKLTDADRNALKGPITALAEDLAQLRGVLGLD
The following text describes a protein:
Function:
May be involved in DNA replication and thus regulate cell proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MSSSSSSNAYDVPWVEKYRPSKVADIVGNEDAVSRLQVIARDGNMPNLILSGPPGTGKTTSILALAHELLGGPNCKEAVLELNASDDRGIDVVRNKIKMFAQKKVTLTPGRHKIVILDEADSMTTGAQQALRRTMEIYSNTTRFALACNTSAKIIEPIQSRCAIVRFSRLSDQEILGRLMVVVQAEKVPYVPEGLEAIIFTADGDMRQALNNLQATYSGFQFVNQANVFKVCDQPHPLHVKNMVRNVIEGNFDEACSGLKQLYDLGYSPTDIITTLFRIIKNYDMAEYLKLEFMKETGFAHMRICDGVGSYLQLCGLLAKLSLVRETAKAV
The following text describes a protein:
Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGPIKYPNMYPYGVKTLTPGQTVVEALDMLGPESSFRLEPLESSMYITPKAAMYNFRGKERRWDVVESHASVGVVLYHKDLDAWIIVRQFRPAVYATLMREAEAAGKPKPPYSEAFTYELCAGLIDKDKSNPEICKEEIMEECGFDVPLEGIHEIGVGIASAGTQGCPHIMYYAEVDSSMAVAGAGGGLLGHGECIEVLALPFESCQQFVLDGKLPKSPGLMFGITWAYFNKLNGSLGAPRVATTSGTGLQNGELVLQSVLPA
The following text describes a protein:
Function:
Chemosensory receptor that negatively regulates RAS/MAPK signaling during vulva induction and the negative regulation of olfaction of volitile attractants. Required for the suppression of vulval induction in response to food starvation. Signaling acts through the GPA-5 G-alpha protein subunit (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAIVSSENRTCADEKLLALYQSWSYIASIVFNCLVPTISTYFLGRAIFQLCNQATIQYSTRILLIATILFAACHQVSYFAFKIDLLHTMFFKLDQPCFLQRSSYDCRFISIAQTTGVVGMALTGLAMSTDRALALTFPADYHKLKSVPRVVLSVFVFIVSFSTWFLLTMNDPLTGYLNHCGFYPSYSVANFQLMLDVILYLAIFNLIWDVILFYYARQQILWRRSYQFQKRYEARISLNCTQAVFVISICQCISNGANSGLMRLLMMIGTSITSVTYSSLLSLFYTAPYSCILLPILMMRISEYIREQRTIGILSLRSEKPGLEEHHQRMRAAWS
The following text describes a protein:
Function:
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
Subcellular Localization:
Nucleus.
Sequence:
GGSSRHEKSLGLLTTKFVSLLQEAQDGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRCLKAEIEDLELKERELDQQKLWLQQSIKNVMEDSINNRFSYVTHEDICSCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESNSSKPVVFPVPPPDDLTQPSSQSSTSVTPPKSTMAAQNLPEQHVSERSQNFQQTPATEISSGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVQILNY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGTQDPSSLEEILWRSPSHVQMMGGYLHSNNILFYFAESPFFDATSNNASLAIQANYNEAFRHFVETREAFEARLKTMQGLEFMVAYDPLQAAAGANAQFVHEPSNVWVIRKQTRRKRSGFEDEVVVLATFFVVGDCIYMAPSAASVIGNRILSAVTSLTSLLKTASTLPKFTPSHGHTYLPPAPKSTDVSHPSVQSQTSKENTPMPDADATNKSQSFTGSQNSSGPAVYDMRSLAESFSLVARYGDEFMDESPLMGEPGSFILSRPGDADRGAAPKQSQPSSTNAGGRVGTPLAKVDTPGKLSDKNSAAEEPKLRKKKSKPAS
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MNDLSEDDMALISELYPGVYMRPSPPPQEAKPPRRRRKKSRGLENPGEEGGGTGGEGRGKRKLTAEQVELLEQNFGDEHKLESERKDRLAAELGLDPRQVAVWFQNRRARWKSKKLEVEYAKLKSVHETVVVEKCRFESEVLKLKEQLSEAEMEIKRLSEKADLGLSGNSPCSSVTADAATDDP
The following text describes a protein:
Function:
Plays an role in early embryonic development.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MAILLHFGVLITAFLSSHVEGKRDPILYCGACRALVDELLYEIRKVNPKKTVDVGSFRISPDGKQEQNKVPFAKSELYLTDVLEEICEKMNDYGLYVDPTTQEKSYKRFAPRDNEGIGSVDFKNFQFNPEESNSLKYACERVVEEHEDEVLSVITKENDNLADKLCTEETGLCKEYLHNEL
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Subcellular Localization:
[Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain; [Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MVVTYVGRRRSALLTLQQRRQFSQQQPNANSSGSFFSGGWKIPATAGFALIGFLQWQQLNHPTDEERKTHPAAALQRLPGSHTVFEGSMATERQLQSLKLFPYRAASRLWGQVHDKELPVWMREPVYKAWTTVFDCKLDEMKYPLQDYANLGEFFSRPLKEGVRPFDSVPGHLASPVDGTVASIGVVNDTADVPTLEQIKGARYRLDEFLGGLPSFFTKKTAASQGKKVFHCVLYLAPGDYHRIHAPVDWQVEERRHFPGNLFPVNQTAARLIPSLFVENERVALLGEWKHGFFSLTAVGATNVGSIVLTKEPEFCSNTSAQDPLVGQCVTKNYGVKVDTTRGEEMAQFKLGSTVVLVFEAPESFEFTIKPGDKVSYGIRAVGLISLQELMA
The following text describes a protein:
Function:
During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
Miscellaneous:
MISCELLANEOUS: [Isoform B]: Contains the N-terminal domain essential for correct neuronal development; MISCELLANEOUS: [Isoform F]: Contains the N-terminal domain essential for correct neuronal development; MISCELLANEOUS: [Isoform H]: Contains the N-terminal domain essential for correct neuronal development; MISCELLANEOUS: [Isoform I]: Contains the N-terminal domain essential for correct neuronal development; MISCELLANEOUS: [Isoform L]: Contains the N-terminal domain essential for correct neuronal development.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Basolateral cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, septate junction. Note=Cytoskeleton- and membrane-associated. Located at the cytoplasmic face of the membrane in the cellular blastoderm and becomes associated with septate junctions which begin to form between epithelial cells at the time of dorsal closure. In adult flies, located at the apical-lateral membrane boundary of epithelial cells.
Sequence:
MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADFIKSSNLNRNCAYEFNNDASSNQTNQSALNQNPIANNVSAQAQAEALSRTFKSELEEILNQRMRIESDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANAEGASEENVLSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKESL
The following text describes a protein:
Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (By similarity). May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Sequence:
MAEVSRDSEAAERGPEGSSPEAVPGDATIPRVKLLDAIVDTFLQKLVADRSYERFTTCYKHFHQLNPEVTQRIYDKFVAQLQTSIREEISEIKEEGNLEAVLNSLDKIIEEGRERGEPAWRPSGIPEKDLCSVMAPYFLKQQDTLCHQVRKQEAKNQELADAVLAGRRQVEELQQQVRALQQTWQALHREQRELLSVLRAPE
The following text describes a protein:
Function:
Central component of the KaiABC oscillator complex, which constitutes the main circadian regulator in cyanobacteria. Complex composition changes during the circadian cycle to control KaiC phosphorylation. KaiA stimulates KaiC autophosphorylation, while KaiB sequesters KaiA, leading to KaiC autodephosphorylation. Clock output pathways impact the RpaA transcriptional regulator. KaiC enhances the autophosphorylation activity of SasA, which then transfers its phosphate group to RpaA to activate it. KaiB and KaiC together enhance the phospho-RpaA dephosphatase activity of CikA; Stimulates SasA autophosphorylation. Fully phosphorylated KaiC (tested with phosphomimetic Asp-431-432-Asp) is the best stimulant, requires the ATPase activity of the CII domain. Unphosphorylated SasA associates with KaiC and its autophosphorylation activity is enhanced. Phospho-SasA is released and associates with RpaA, transferring its phosphate group. Formation of the KaiA:KaiB complex is promoted by KaiC, helping switch KaiC from its autophosphorylation to autodephosphatase function; Has a weak, temperature-independent ATPase activity (about 14 molecules of ATP per day) that defines the circadian period. ATPase activity is mostly contributed by the CI domain; the CII domain augments the activity. The addition of KaiA increases activity. ATPase is inhibited during the KaiC phosphorylating phase and activated during the KaiC dephosphorylating phase.
Domain:
In the homohexamer the 2 domains (called CI and CII) self-associate to each form a 'donut' layer. The KaiC CI domain mediates interaction with KaiB, CikA and SasA. ATP hydrolysis by the CI domain causes a conformational change that allows KaiB binding. The 2 domains communicate to control ATPase activity; In the homohexamer the 2 domains (called CI and CII) self-associate to each form a 'donut' layer; the compactness and local conformation of the domains varies over the cell cycle and impacts function. CII has the autokinase and autophosphatase activities, both CI and CII have (weak) ATPase activity; CI has the clock pacemaker role.
Sequence:
MTNLPEHQSSPTEQSSAEVKKIPTMIEGFDDISHGGLPQGRTTLVSGTSGTGKTLFAVQFLYNGITIFNEPGIFVTFEESPQDIIKNALSFGWNLQSLIDQGKLFILDASPDPDGQEVAGDFDLSALIERIQYAIRKYKATRVSIDSVTAVFQQYDAASVVRREIFRLAFRLKQLGVTTIMTTERVDEYGPVARFGVEEFVSDNVVILRNVLEGERRRRTVEILKLRGTTHMKGEYPFTINNGINIFPLGAMRLTQRSSNVRVSSGVKTLDEMCGGGFFKDSIILATGATGTGKTLLVSKFLETGCQQGERALLFAYEESRAQLSRNASSWGIDFEELERRGLLRIICAYPESAGLEDHLQIIKSEIADFKPSRVAIDSLSALARGVSNNAFRQFVIGVTGFAKQEEITGFFTNTTDQFMGSNSITESHISTITDTILLLQYVEIRGEMSRAINVFKMRGSWHDKGIREYVITEKGAEIRDSFRNFEGIISGTPTRISVDEKTELARIAKGMQDLESE