lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.
Subcellular Localization:
Nucleus.
Sequence:
MGSRLDATSSAVRKRIQSHAFDDEEGEEYEASKFGGFSDYMRRKKTKLQNLDNDIRSSAAADNCPQIFRSVVACVNGYTQPSLQDLHKLIVRHGGGFLQYLDGKTSATHIIASSLTPKKREEFRRYRVVKPAWVVDSVNAGRLLPWDLYRVLDEGQGQKVLNFEGGRIVSQANSHRTNYKDESRASRYTSQWPSERATNDRSPDPPETPASKQSNDATQSDYGDFPSFSSLDQPAQSATSPSSPPPHGQGDRLGEPVITPGEPAENQRTDMGTTLSPQQPDPRMRNSSVVNPDFLQQYYKESRLHHLSTWKAELKAQLQSKAQEKARSQRRKKLVPGARRYIMHVDFDCFFAAVSTLKHPELEGKPVAIAHGTGTGSEIASCNYVARASGVKNGMWMKGALQACPDLRVLPYDFPAYEEASRKFYRAILGIDGLVQSVSIDEALVDITTICLEAGGSEGKGVSEGSIYREQAKADEVAEQLRAAIKRETGCAVSVGIGGNILQAKVALRKAKPAGQFQLKPDAVLDFIGELPVQNLPGVGYSLSAKLEDLGVKIVKDIRDLSREKLSSSLGPKTGAKLADYARGIDRTEVGNEVTRKSVSAEVNWGIRFVTQDQAEDFMRSLCEELHRRLVENLMKGQQLTLKVMRRALDAPLEAVKHLGHGKCDVFNKSVILGIATNAADVLGKEAIAMLRSLAISPGDLRGLGVQMTKLEPLKSTSEKSDGSQQQLAFKASTAPKRAQPIDDPDLLDSPRKGESESIRHGPQLNDTTQKLLNTSGTQFIMPSQPDPAVVAELPDDIRSKLVAQGKPRTTSRAGSPMGPGPAVRQQPAPALPPQSQLDPETLAELPEDVLAEVLGYYNQPSVNNTGSTKPQTESSPQPRPSGSTLKLRKPTTPPKKRRGRPPLKPSQPSTLTQAKFAFPKSDTRPCRLSPFQDHELTSDPEISADFLAALPEDIRCEVLEEQKQKRSRLLHQRTASTTAPRTVPADRGHSQHQEKHINLPNLPPRPTFTSKRLSNPSDLRDEATAWHATFAQEGPFREDVTALAIYLKRVVAEERDVEKAVSLVKWLVWLVEDDRANGGANDRASIGASSTVGTGKESQEGVPGTQCAISWDEALKCLKDGVLEGLEERGMPAVDFLD
The following text describes a protein:
Function:
High-affinity copper transporter of plasma membrane that mediates copper uptake under low copper conditions. The mechanism driving the transmembrane transport of copper has still to be determined (Probable). Acts as a potential virulence factor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNMDHSSHSTMSSSSSMTMTMVFTNSHDTPLFSSAWTPSSSGAYAGTCIFLVVLAIINRCLVAFKASMEHYWFATHLNRRYIAIAGKSSEAGRIDTDPDAKVASLVTAQGVEESVKVVRRVSREPIPWRFSVDLPRAAIFLCITGVSYLLMLAVMTMNVGYFCSVLAGAFLGELAVGRYIQWNEHDH
The following text describes a protein:
Function:
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
Sequence:
MFMNDFKAIILAAGQGKRMKTDLPKVLHPLYENTLLEFLLETVKTVFEKEYILVVSPKVRTYLNSISEENVVIQDVPLGTGDAVKRLENWLDAYEGDVLILPGDMPLIKSETLIKICNVHRENNNICTLVTTFLDNPCGYGRVVRDKSGEVLKIVEEKDATEEEKKIKEINTSVYAFKWRELREVLQLLKNDNAQGEFYLTDVIEIFNKRNLKIGTVVVDPVEVLGANTQEELSTLRKILKERINKINMNNGVIIIDPDTVIIGHKVSIEKDVIIQPEVFILGNYVIKKNSYIGPLSYINSKTE
The following text describes a protein:
Function:
Essential in the female germline for proper survival, sex determination and differentiation. Participates in the transcriptional activation of Otu. Does not regulate the expression of Ovo.
Subcellular Localization:
Nucleus. Note=Associates with decondensed chromatin, including sites of active transcription.
Sequence:
MSVNLDGSEEKMELKKHVPYILNGELYRIEKQVGDNVTVKCCYCPPDRIYRGSVRSTGNFHMHIKRRHSSLLGKLHEMKVAALEERRDRIMKNRRFAKSRKKAPVAVAATSTAAQSDSGVFVDMQAAVPSGNESHELKIKTVFQRHKQEQEGATRKLEDSTSDKANLPNIPKNLGIVVQNVSNISVETLPGGSTPASVSFLGRPVKPEQGSGPSFLADQPAAIDLSQVPPVQGESKSSGSLASSMEDVSMEYSRSQALSQSLSMAHFLEHPQRDVLQRLERSMAQISQELHCRNRIEHNRMLLEAAKFKFLNPNFQFEPNL
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MISIILVMIGGGFGAIARSAITDYFNHKFTSKLPIATLIVNLVGSFLIGLTIGLSISISWFPAFFVTGFLGGLTTFSTLAKELTLMMTPKFNINLFLNYSLLQFIIGFIACYIGYHI
The following text describes a protein:
Function:
Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPTKGKPSTKGKSAKLGAKSSAKSKSSASKPEGISKNRQKKLTLAKPGGAQKTKSRTKDGRKKKRVYSEKELDIPLLNGIVPAGIAKPKGEKKGKIFVDDPASMMAIMSVVNAEKEGRIESKITRARQLEEIREAKRVEAEGRRDEKDKAFEERKEGLKKKRRRSAPAKGGDDDDEGKAKKSKKDGKYKARKRVSFG
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MHGRFALLSFCVLLFLLCLCLQRLMMEDSQAAQIAINGFIGSILIVVCSITYVLWAVLPDDVLHRLHLTYYPDRYWAVAIPAILVMFLFHYFTTSWLLVLVTTHPLTDGRCITDVDSKPDKEIEVGALADSSSSVPPWVDIPVSVASNLLFEPWNEKVR
The following text describes a protein:
Function:
Probably functions as a manganese efflux pump.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MGFYALLLIALGMSMDAFAVALAKGAAVRMPPRKIAATALVFGTVEALTPLAGWVGGFYAKPFISEWDHWVAFVLLGGLGLKMMREGLSGEAEDVRESKRESLWMTVLTAFGTSIDSMIVGVGLAFMEVNIAFAAAIIGMATTVMVAVGLTAGRALGVLFGRCAEFAGGLVLIAIGTWTLLSHLGLIQ
The following text describes a protein:
Function:
Component of the Cdk8 module/Srb8-11 module which is a regulatory module of the Mediator complex that regulates basal RNA polymerase II transcription. The Cdk8 module may sterically hinder the interaction between Mediator and RNA polymerase II leading to transcriptional repression of a subset of genes regulated by Mediator.
Subcellular Localization:
Nucleus.
Sequence:
MAANYWASSQLTQLFLSTDLESLEPTCLSKDTIYQWKVVQTFGDRLRLRQRVLATAIVLLRRYMLKKNEEKGFSLEALVATCIYLSCKVEECPVHIRTICNEANDLWSLKVKLSRSNISEIEFEIISVLDAFLIVHHPYTSLEQAFHDGIINQKQLEFAWSIVNDSYASSLCLMAHPHQLAYAALLISCCNDENTIPKLLDLIKSTDAFKVILCVQRIISIYYFEDIE
The following text describes a protein:
Function:
Involved in RNA editing. Catalyzes the specific deamination of adenosine-34 in several cytosolic tRNA species. Generates inosine at the wobble position of the anticodon loop.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes predominantly to the nucleus.
Sequence:
MDSDAWEIIHIPEKPSLSPDHQPTVKVYASLIKPRFANTIVRHLCKIAPLEDLRHVKRVKKKILPDCGETQLTVILCLAPEHNDQLSDMPPDVQRLVDPYELSPFITQVCKYAAVSKEEWEEQSKIWPTSFHPPTYNIDGIGGFSEEETQSICKFMRVVIDMAVSGHTPLVNAAVIVDPSVRRIIASETDQVYASSAPRDMTSAETRPFEETGEICLNDTLEKQNGSLSALSCLNPWQWSLQPHDTENCSQWHPLRHASMVAIESSSARDRNLFPNPSKIFDQDHVPPSNTDSPAKKQKTSSQSPDVQNDSREETVRDPSMERPYLCTGYDIFLLLEPCTMCAMALVHQRIKRIFYAFPNTTAGGLGSVHRLQGEKSLNHHYAVFRVLLPDDALRQMTTV
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
GGDRWEGEDEDEDVKDNWDDDDDEKKEEAEVKPEVKISEKKKIAEKIKEKERQQKKRQEEIKKRLEEPEEPKVLTPEEQLADKLRLKKLQEESDLELAKETFGVNNTVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MKISCFLLLVLSLSCFQINSVSGIDSVKCFQKNNTCHTIRCPYFQDEVGTCYEGRGKCCQKRLLSIRVPKKKV
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MADKFPALEDIDDLPQDVEVDVDIKDTHADEDDFKKSFPSLEDEENDLTENAFKEDFPALEEETQATTGNVVTAEATEDSSPVDGLETSVKSLNLSESTAIKEWKERQQLEIERRDQQAEAKRKETIEKAQKAIDDFYENYNSKRDEGVKSTQEAAKEFLASIDDTSSSSGTTWDRALKLIDDSDTGTKEGSRDKTRFREILLSLKGDVDAPGAAGY
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSLTVTCSRDLVLSAPVKLAEGVQVVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTTVASARWPAARFAVRNVAVQGPNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRAIAACRTPVVSAVGHEPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQLRSRPVLADPMTMVSVRAEEVHRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLARGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRVADGALAAVSEGQTNGL
The following text describes a protein:
Function:
Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.
Subcellular Localization:
Cell junction, tight junction. Membrane; Peripheral membrane protein.
Sequence:
MSKPGAKKSHWTSRVNECAVIKDARGELNVSLRGGAEHGEFAVIGPVNDNLVIYKHGRLNEGELLLEVENLSISGLPLYDVESVIRNCKGPVRLKTVRPGNKLNKDLKTYLSQRFQKSSADHELQQTIRDNLYRHAVPCTTRAPRDQEVHGVDYNFLSVEDFLKLEKSGTLLEIGSYDGNYYGTPKPPVQPPGGKVISNSSSGGDVPLLVGLNSSLPGSQNSTPRRAKSYNDMHNAGIGFGEPQLEDDEDLPDMNSSITGDSSELDEIHHSVRPYVPRQSDLSYSGTSPSPSATTESTQQTNFHLSHPPQEDQLGPLPENWEMAYTDSGEVYFIDHNTKTTSWIDPRCLDKPQKPLEECEDDEGVHTEELDNDLELPPGWERIDDPVYGVYYVDHINRKTQYEHPVLEAKKRRQLEQQPQPQSQQPPEEWIEDSALAGAPLTNYASNHETYRDPQTGPTVPNAMGQKRGKPFFTRNRSELKGTFINTKLKKSRRGFGFTVVGGDEPDEFLQIKSLVVDGPAALDGKMETGDVIVSVNDICVLGYTHAQVVKIFQSIPIGSMVNLELCRGYPLPFDPDDPNTSLVTSVAILDNKEPIIVNGQEVTNSYDSSASYSSQSTYNGPTNSGAPLNGLPRPISPSTEVASDTSSQLGYSSDVVNLASSIATQPELITVHMEKGDKGFGFTIADSPGGGGQRVKQIVDYPRCRGLREGDIIVEVNKRNVQSMSHNQVVDLLSKCPKGSEVTMLVQRGVAPAKKSPKLDYVHAAPPYKDYTRMQLSRKDSQNSSQQSVSSHRSAHTDSPLHQSLAAPLNESSAPPPPSQPLPGLPAQDSQGDGTIQRKPDPFKIWAQSRSMYESRLPDFQEQDIFLWRKDTGFGFRILGGNEPGEPIYIGHIVKYGAADEDGRLRSGDELICVDGTAVVGKSHQLVVQLMQQAAKQGHVNLTVRRKTSYAVKAEGDVPPSPASSHHSSNQAPSLTEDMGKRTLQGSQNSLNTVSSGSGSTSGIGSGGGGTGLPVGGNAVVAAVSANSTSSQPPNSTSIASSSSTLQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGYSITNMSHSDIVNLIKEAGNTVTLRIIPGDESSNASLLTNADKIATITTTHTPQQQAAPEARINTKPKQESFDYKPPQAPPPQPPVQPSPPQDGEFYSVDLERDNKGFGFSLRGGREYNMDLYVLRLAEDGAAVRNGKMRVGDEILEINGESTKGMKHARAIELIKNGGRRVHLVLKRGDGSVPEYDGNVVDGAISANTATGVQNAAEVSTLPPNDVPSELSFPPEPQQPSRSKEPTNRSEGTGKPHRSKHRHHSPTKTSKGKHRRNKSPGKSGPKQSKKKNSKENDQHHSNGHHRRRHRSPNKGQRSRSADNNLDSGHRGQRRGRSPERRQGQHSSSNHRHHSPRRSPYHPPRRSPYRSPHRSPRQSPYRHRSPYRSRYHSPNRRRYHSSDPYRNSSPNRQTRGNEKPNVDEAVLREPFQTPEPSFGFDDTVLRETPALDRLNRDSTLQPLGRDDRLFGDNSLLAKASTMDRAYRRRDVPSRSQPNDYRDPILPRVRTPDFDSAYLKYSTLLRGRSPALTEGDGRFGSRDSIPEPRYRARSLGRDISPVRTFRRDDSEDEEDDDIFVAERVREYHSMLKTNTTHSSKPLLPEPKKTYKENPKDLSI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSSCFVPNGASLEDCHSNLFCLADLTGIKWKCFVWQGPTSSPILFPVTEEDPILCSFSRCLKADVLSVWRRHQTPGRRELWIFWWGDDPNFAELVHHDLSCNEDGSWESGLTYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFVHGDSNVCTSVEINQHQPVYLLSEEHLTLAQQSSSSVQVILSPYGLSGTLTGQSFKLSDPPTQKLIEEWKQFYPIGPNTKEVTDDKMDDLDWEDDSLAAVEVVVAGVRMVYPASLVLVAQSDIPLVATVSSSSSSGSYAGAPHNQLVHGDTGISSVTLTPPTSPEEAQAVSQPAQKWVKLSAMSGVFSVDSSSHHGGKIPRRLASQMVERVWQECNINRAQNKRKFSTMSNGVCEEETDKASVWDFVESSQRSQCSCSRLKNQKQRACSTPGHPPSAGQPPQPSTKHKMAEKLEKGDKQQKRPLTPFHHRSSLCEEQPSLEQGESVHRLCLQGHEDSRYPSLHHADVTSSKTPMLHSSADEMAGSPQPPPLSPHPCERMEEPADGMKSSSSPLHQHFYPPSSEPCLEPQKPPDESTLDPLPLPCPPPYPETLEATIYVGSAINPNEDTTHNPWKYFRVPGGRNSDFHTPHLPVVAHFEDGNRTGGQDGIVSITEMMSSSKRPLKVSEELVKMYEHKKNQYLSSAVCDEDPEQESDPYAFEEGDEEFNFSDKDKKSGPEREAGKKAKREDGSSSSDDAQGSGGSKPLPTTSLIHETDLVVSINDLDNLFNSDEDDLTQPGSRRAAGGAEEKFGGKEPKPAAPDPLPCCADLHQMFPTPPSLDQGYSPINMGNTESAAGLSLLDGAMSGNFKMEVEEGFCSPKPSEIKDFSYVFKPESCQALIGCSLYAPLKTLPSQCLLPVKLPEECVYRPSWTVGKLGMLQPMAAMTFLNKDSNIPSVGSVVEQEQSCTPQTHNTFMSNSAPPSNSGAGILPSPATPRISAPTPRTPRTPRTPRGPASVQGSLKYENSDLNSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCICVCNMNITGADVGIYISDPNMDSQYSSMDPCSCGFSAVMNRRYGNGAGLFLEDELDIMGRGSDAAREIEKHFEAVRAASLKRGTVLEEQVPDDLMLLLQDLCTNPFSPIIRPDLLGTVIKSPIRLEERDYYSDCYMALEHGRQFMDNMSGGKVDETLVKSSSLHHWAKRNAFDMSMLFSQDVLRMLLSLQPVLQDTIQKKRSVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTLLVGYEYDYVVLSPFALPYWEKLLLDPYSSQRDVGYMVVCPDNEALLNGAKTFFRDLTAVYESCRLGQHRPIAKSHADGIVTVSDAGSKALTDQTLIDWLPKTINSSSSSEALNKLKLYAHVCRHDLASCLASQSLDGSLLTQRNPASSSQTSSSSSPVTTAQNVTPTTNSNSNTNTNTTPTSTSTSSSSSSCPQGVGNMPSSKPNTIPPFGAQGLQSSQQSGGQSAGTLGDATSATSQPQVPSEPAESTMEREKVGVPTDGDSHAVTYPPAIVIYIVNPFSYEENCQGSSSSVWTIALLRCYLEMLQLLPPHIRNAVYVQIIPSQYLLQPVWSEERHIYAQHLKSLAFSVYTQCRRRLPTSTNVKTLTGFGPGLAIDTALQSKERPQCLHLYAPPFVLAPVKDKQTELGETFGEAAQKYNVLFVAYCLSHDQRWLLASCTDQYGELLETCVISIDVPNRARRKKGSARRQGLQKLWEWCLDLVQMTSLPWRIVIGRLGRIGHGELRDWSILLSRRNLQSLGRRLKEMCRMCGISAADSPSILSTCLVAMEPQASFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAGLQAFSDVTDGMGGMDGILDLFAENDLVDPDLINIIPNSPTTSPVHSPGSHYHHGGDGSKGQGTDRMESHDESPNILQQPMALGYFVSTAKAGPLPDWFWSSCPQAKNQCPLFLKASLHLNVSSVQSDELLHSKHSHPLDSSHTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQMYNFIMNML
The following text describes a protein:
Function:
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome.
Sequence:
MGSTDKPSIVNQLQGEMAELHHIQYSTDFSTDVNRKMQIPSRLSMEPEEPFMVDPPSPTHNFNLNSESFEGSPAHAMNVPERILIAGSDQHVGARQAPRNLDLDDMPAFQPSNNVGLTTPPRTMTLDEISFPTVGDKSAMKAKAAAQVVRQSSDPNSSVLLADNTALVEGVQDSDWDKLQRKMHLLSSRVSSLEEAGRKQEQRETIIMGVGIVYLLFRGLRFLFRSPYP
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MAARDDLAALREQTALASSSAVSVSDLDLAYQLQLAEAIQASLRLDALSSNPSSSKGKAPFAAAAASSSSSRSQPAPAPPEPSDASYALAVHAADLARAEEDHRYAEACRAYHARAAASACVAAHDAIFARELAAVPEDQWAHDGDNIERPLDSTKPLFRVMFKGMASKEVVGSRDWDPRIAVLAVALCDSQGKVVLRIQKPVEGFVGGRMMLEAMALTEGLQAALALGIQSIRIVNDYKALHNHVRGIWRPKQAKLAEMIDQVLSVAKKFKQCEISLVERGKLDYVMKLATDSILSQIAKAVAVNASKEKRETCAICLEDTDVSKIHVVEGCAHRFCFCCMKEHVKVKLLHGTLPACPQDGCTTKLTVEGSKIFLSPRLLDIMVQRIREGQIPATQKIYCPYPKCSALMSLSEIKHPLQESSSKYTIADAATLRKCVKCRGSFCISCKVPWHDRMSCYDYKSRYPQARPDDAKLQNLARQQLWRQCVKCKHMIELSEGCYHMTCVCGYEFCYTCGKEWKDKKATCSCPLWDEDNIIRDGMEEDDGMEEDDDDEDDDYDYDDDEDDYYAREGQHYDRQNAGHHHGGGGAQNFYDYNNNPRHLPRHGGGGARNLYDYNNNPGHLPRPGGGGARNFYNYN
The following text describes a protein:
Function:
Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids in the presence of NADPH. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function (By similarity). Among further tested androgens epiandrosterone and dehydroepiandrosterone are accepted as substrates and reduced at C-17. Can also reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms. Cannot use androsterone and androstanedione as substrates.
Subcellular Localization:
Endoplasmic reticulum. Membrane; Single-pass membrane protein.
Sequence:
MTLTEIIFVLTGTCAILVFGGKIASLIMMLITKLFCPLPEAFFTSLGKWAVITGGSDGIGRAYAEELSKQGMSVIIISRNQEKLDRAAKKIELNTGGKVKVIAADFTKDDIYGHITENIEGLDIGVLVNNVGILPSQIPCKLLETSDLEERIYDIVNCNVKSMVKMCRIVLPGMQQRRRGVILNVSSGIAKIPCPIYTLYAASKVFVERFSQGLQAEYISKGIIIQTVAPFGVSTAMTGHQKPDMVTFTAEEFVRSSLKYLKTGDQTYGSITHTLLGRIVQSIPTWVLQSETFQHHFQEYVKNRDRR
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MTRQPANDATGTDTPDRGLSGTDLVVRYPGGDDPVIDGESVTVPVGDVTALIGPNGSGKSTLLNALANKHSPADGTVLLDGHTIDELGSKELARRLGLLSQENVTPGGISVRELVERGRYPHQGFFDSLTDADRAAVTDALRVAGVDHLSGRDVGSLSGGQKQLVWIAMALAQDTDVLLLDEPTTFLDPHHQLEVMDIIQALRDDHDTTVVVVLHDINQAARYADHVIALKDGTIHARGQPADVVTKETLRTVFDIEATVSTTSHGMQVVPIEALHDEDGTDHEHAPGSRTPTRETAADGGTPPAE
The following text describes a protein:
Function:
Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction. Synapse. Note=In the brain, PRIMA linked to ACHE is found in membrane rafts.
Domain:
The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits.
Sequence:
MLLRDLVPRHGCCWPSLLLHCALHPLWGLVQVTHAEPQKSCSKVTDSCQHICQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPAEDSWWSGLVIIVAVVCASLVFLTVLVIICYKAIKRKPLRKDENGTSVAEYPMSSSQSHKGVDVNAAVV
The following text describes a protein:
Function:
Inositol phosphate kinase with a broad substrate specificity.
Sequence:
MASPNRYIPSKNQVAGHRFEEGRVGSLVDGSGLFFKPLQGDERGEREVAFYDKFWQDESVPASIKCFFPKFFGVKELEAAGPVGKLKHAALEDLTHAYKNPSIVDIKMGKQTWYPGCSEEYEQKCRAKDATTPSPELGFRVSGMQIFDPRTGDTWRADRQWGKSLDAQGTAGALKRFVLPFDDEVSRRNAVARIHDLLARLKEFQQWFESQGTYHFYSASLLLMYDSISSDVPSNSSTQPKAQQSESPEADHSKEGASASPPTSPLEVRLIDFAHVVDGKGEPDTNFLFGLRSLIELYNRVFSEIESKN
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
FASEIAGVDDLGTTGRKTESIDVMDAVGSNIVVSTRFAYDGLKRQRLTEPMVRGLLTYTSWEDALSRFEAPLFNARVALIGSPVDLTYRYDHLGDSPKIASQVAALDLGYKPGVEAIRKNPPKLLFLLGADGGCITRSATYVNTEGRVAVTPPGLAREDWKALSEIAGITLPYDTLDQVRDFYMTDSISR
The following text describes a protein:
Function:
Required for correct cell separation at high temperatures.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell tip.
Sequence:
MIRNTLAFLAILFLLIPTALLIIGSVSVPSTRMTLAKVEGTEFGIFGTCTGNGTDCTETSFGYNASSSLIDDFYYKGDKRLVLSKVLITHIISAFLSFLSAIFVFFSIFLVNQAVNIINIIVVFITTLLTCLAFAIELVLFLPHNTWQSYVTAGAIGSDLIAILALCLRSVSISRIGQKSARLEHVDTMNSSYSSYKTDVKYPLALDDKLSSVPTLPKFHDALTSTSEFGPPSDSGDTVGTTQYPGDIKYATGYESTVASPVPSRVAKLSSRDTPSIIADYDEFRKSESSPSRSSVLSTSKPEVHETEGYCPHKTGNRPGFPSLNIPRTRPTTAGIANTQFDLEPYRNRQAGSISSEGTDSRFFDVENQVSVAQTPSVKPEMFPKTARPFAAIHANASSTQLRNTENITHPGIPNHFAKTTSSVFDEPPATRMPQTRSPVNDHSSFPSDLPIKGEMSTNMTGAPRVGSRNNSSNDLHAQAGMLKNVGNGPRNAPRNNSSNNLHAQGGMPMNMRGPRGAPRNNSSGDLHIQSGMPMNGRNGPRDTSRNNSSSDLYAQSGMHPNMNNGHRGAPRNNSSNDLHAHGGMPVNMRGPRNTSRNNSSSEFNAQIPMNLRNGPRNASRSNSSTDLFGQSGIPGNSRGMPTSPNSRNNSALDLSMHGIPLANNSRQFKRPSYGNMSRPSFELNGSRNPSHGSLNTAHAGMGYGPRSMMRDPQNLSNVPPVSNTLDQLSGNADFELPVRGNRNNRRGPGGNRMIR
The following text describes a protein:
Function:
Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer.
Sequence:
MRMLAAERRDHLLGLLARQGKIVAKDVAAELRISEDTVRRDLRDLASEGLCQRVYGGALPVSPAVADYGARRTVAPDGKRKVASAAAGLVRPGGVVILDGGTTALAVVHALPEDLDCTVITHSPTIAAALLDHPRAEVFVLGGRLFKHSAVACGAAAVEAAQNVSADLFLLGVTGVHLEAGLTTGDAEDAAMKRALAARAADTYVLASSEKIGTASRYRVLPWEEISGLVTDTPPHDPVIEQLTAGGVDVLAAD
The following text describes a protein:
Function:
May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis.
Sequence:
MVRSGGLLTSIRDPVALKSIAVTLSINDFVAGVSATLNYENEEKSPLEAFFVFPMDEDSAVYSFEAFVDGKKIVAELQDKYQAHKRYEEALSGGYQAYLLEEDKCSRDVFCCNVGNLQPGSKVSLTLRYVQELPLEDDGALRYVLPAILNPRYHLSDGREDSNLDMKTPIVPLEELPYTLSMVATISSQLGISTIQSNCPLNPIEYTGDNKTSAQVSLAEGHKFDRDVELLIFYRKVHSPSVAVEMGMSGRPSDSLMGAPSAMVSFYPDIPEVETTTKCGEFVFLMDRSRSMNSPMSSKDKSQLRIDAAKETLILLLKSLPMGCYFNIYGFGATHEEFFPDSVMYNQETMQIAVKKVKRLLADLGGTELLTPLRKIFRKPPIPGHPLQVFVFTDGEVVETFSVIREVMFQSKKHRCFSFGIGEGASTSLIKNLARVSGGTAEFITGNDRMQSKALRSLRRSLQSVVEDVSLSWNLPPKMFAPMLSPEQTSIFRGQRLIIYSLLIGKIPKEEATGEVCLSYKLHGKSYEEKVTFSLQPKPDDNLTIHRLAAKSMIQSKDFGFKETSLMYKRDVLDISLESGVMSSFTAFVAINKELNEPIQGPLVHRDIPRPILLGAGPNRPSDGGYPKTLFCASAPVTLPPWLKGSGKCVATILMPNGTPQQRQNSQKKKCVVHTDTRPELPHLAKYDSYPQGSKEHSIAQLIYLQNADGSWDMNEDLAKILSTSLEDITAACPTEVLEPSAWATMLAVIWLHANGKELKDEWELLERKAVVWLHNNSVRGFNKLIRTANKLLKTSLSPSIFKL
The following text describes a protein:
Function:
Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation.
Subcellular Localization:
Secreted. Note=Secreted by epididymal cells and is absorbed to the surface of sperm during transit through the epididymis (By similarity). Mainly located on the sperm acrosome.
Sequence:
MKSLLFTLAVFMLLAQLVSGNWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPADRRANYPVFCVQTKTTRISTVTATTATTTLMMTTASMSSMAPTPVSPTG
The following text describes a protein:
Function:
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MAAEAWLWRWGWGWGQRCPGRPGLPGPGPSPTTFLHLLLLLGPVAADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVMVNNGSLSYDHSKDGRWSELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISIKLFQLTVERTPEEESIDWTKIEPGVNFLKSPKDNVDDPTGNFRNGPLTGWRVFLLLLCALLGVVVCAVVGAVVFQKRQERNKRFY
The following text describes a protein:
Function:
Catalyzes the hydroxylation of L-isoleucine to produce (4S)-4-hydroxy-L-isoleucine. Can also catalyze the hydroxylation of L-leucine, L-norvaline, L-norleucine and L-allo-isoleucine, as well as the sulfoxidation of L-methionine, L-ethionine, S-methyl-L-cysteine, S-ethyl-L-cysteine, and S-allyl-L-cysteine.
Sequence:
MKMSGFSIEEKVHEFESKGFLEISNEIFLQEEENHSLLTQAQLDYYNLEDDAYGECRARSYSRYIKYVDSPDYILDNSNDYFQSKEYNYDDGGKVRQFNSINDSFLCNPLIQNIVRFDTEFAFKTNIIDKSKDLIIGLHQVRYKATKERPSFSSPIWLHKDDEPVVFLHLMNLSNTAIGGDNLIANSPREINQFISLKEPLETLVFGQKVFHAVTPLGTECSTEAFRDILLVTFSYKETK