lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential for recycling GMP and indirectly, cGMP.
Subcellular Localization:
Cytoplasm.
Sequence:
MMASAPQDRPAGTPPQGRGLLIVVTGASGVGKGTLRERWLAGQDVFYSTSWTTREPRPGEVNGRDYVFVSPAEFLAKAQQNGFLEHAQFVGNHYGTPIEPIEAALERGQDVVLEIEVEGAMQVKDRMGEQAILVFIMPPSLTELRRRLTGRATETPERIEKRLTRARDEIQAAHDFRYVIVNDNLDRAVSELLAVQQAERAAQKAAEHWTPEEQQARALADTVRSTALSREALQQVVES
The following text describes a protein:
Function:
May play a role in maintenance and/or transport of vesicles.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMPSCNRSCSCSRGPSVEDGKWYGVRSYLHLFYEDCAGTALSDDPEGPPVLCPRRPWPSLCWKISLSSGTLLLLLGVAALTTGYAVPPKLEGIGEGEFLVLDQRAADYNQALGTCRLAGTALCVAAGVLLAICLFWAMIGWLSQDTKAEPLDPEADSHVEVFGDEPEQQLSPIFRNASGQSWFSPPASPFGQSSVQTIQPKRDS
The following text describes a protein:
Function:
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
Sequence:
MIHKMAGQKVALLFLSVFLVASEALNLNDQPCLVRSNNRHLLGVKNYPRPWEYLKVSDMPKQWDWRNMNGTNYVSTTRNQHIPQYCGSCWAMGSTSAMADRINIQRKGAWPSAYLSVQNVLDCGNAGTCHGGDDLPVWEYAHRNGIPDETCNNYQAKDQECNKFDACGTCTTFGECASIQNYTVWKVGDYGSVKGREKIMAEVYKNGPISCGIMVTDGFEKYTGGVFSEHHIFSAENHVLSIAGWGVDDDGTEYWIGRNSWGTPWGESGWFKIVTSLYKNGEGDKYNLGIEENCAYGDIVGMTTVS
The following text describes a protein:
Function:
Binds to F-actin. May be involved in regulation of the actin cytoskeleton.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MREQHFKDNFWNTDITSTAGYDTIIQHLNDGKRTCKEIEDFMKARAAIEEKYAKELLGLSKKVCGHSEMNTLKRSLDVFKLQTENMSLSHLHLAQTMREEAKKLEDFREKQKEARKKVEQQMDALHKQKAAQYKKTAEAKKSYDQKCRDKEETEQNMNRSATTCSAKQQEKLYAKTQQAKQAAEEADRIYSQNVSVLGKMREEWLNEHVKACEFFEKQEVERINTLRNIVWTHLNHLSQQCVSSDEIYEEVRKSLEQCNIQEDIEHFVNLRRTGDKPPAPIPYENFYNNQRSGVVRSLPPPRRAAAPPPPAAGNDPLYSTVAEPGYSILRY
The following text describes a protein:
Function:
Potassium channel; forms a potassium-permeable leak-like channel with weak selectivity for potassium. The channel is permeable for K(+), Rb(+) and Cs(+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The six transmembrane regions are tightly packed within each subunit without undergoing domain swapping. Transmembranes TM1-TM3 are positioned on the inner circle of the channel tetramer and participate in inter-subunit interactions that are central to the assembly of the ion conduction pore. The RxxxFSD motif within transmembrane TM1 coordinates a network of specific inter- and intra-subunit interactions with other conserved residues on TM2 and TM3 and plays a key role in the tetrameric assembly of the channel. Transmembrane TM4-TM6 are positioned on the periphery of the channel and do not contribute to contacts with neighboring subunits (By similarity). Transmembrane TM1 forms the pore-lining inner helix at the center of the channel, creating an hourglass-shaped ion permeation pathway in the channel tetramer (By similarity). Hydrophobic residues (Leu-35, Leu-39 and Leu-42) on the C-terminal half of the TM1 helix form a bottleneck along the ion conduction pathway and serve as the selectivity filter of the channel. Thr-38 is required for potassium ion selectivity.
Sequence:
MRKVFETVVGLNPNFSFRGKQQTRIETFSDAVFALAITLLVLSSTIPETFEDLWASMRDVIPFAICVALIIVIWYQHYIFFLKYGLQDKVTILLNTILLFVLLVYVYPLKFLARFLSEIYGGIFGIIETDLSRFGEYSHQNLKLLMVNYGLGAFAIFLVFSLMYWRAYKMKSLLDLNSYEIFDTKSSIIANLLMCSVPLLSLIITLIDPWGNFRTTILSGFLYFLYVPIMIVFGRITSKKSRRLLQD
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MADDNPQKFTDLPLSPVTFGVRDKFPTISRTLVKFQAARMTSIQAKAIPLLLRGDDLAAYSSNGSGKTLAYLIPALDHLCKNKYEPDDGIIVMVLCPNTMVAIQIDRDIKTILKDSPQTLQTIGRLIASPGDRYVRKNLLIATPAGLRYHHAYDPERIKYDKLKFLIFDDPYLILRFSDQKKWNWVRSNFPKEQLQIAIFSVTKLKRECLLRLLPEGRRPGDFSVIDEVQNRQWVTNDRLEQEFILVPCAKRLITLYIMLKTTKSKKVMVFFSTTESVKFHEELFTFLDVKCYGVHGDQTVSEHSKIYYSFSNAEEMILLCTNIAAFGLNIPDVDLIVQYDPPIDPEEYIHKVGRTARGTRKGNALLFLMPHELRFISFMKTHKVLIREHMFDEKMAPNVGSYLLRLVAETEELMEMATKAYIEYISAYNLITMRDIFGIHLLDKEAVAASFCLWNPVTEAI
The following text describes a protein:
Function:
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTRVIVISNLRLAQAFVDYMATHHVALEIRPDAQGVEIWLADDEQLSAVQHELEQFLLDPLNPRYQAASWQAGNVNSNLPYQRFSYLQTLRSQAGPLTLSVMVLCIAIYILMLITGDMAVMSWLAWPYNSSQYLQIWRWVSHAFLHFSLLHILFNLMWWWYLGGQMEKRLGTSKLLVLTIVSAVFSGWGQSLFSGANFGGLSGVVYALMGYVWLTGERAPERGISLPRGLMAFSVLWLIAGYFDILGLSIANAAHVSGLIIGLLMAFWDTRNSARTVQ
The following text describes a protein:
Function:
May be involved in intracellular vesicle transport.
Miscellaneous:
MISCELLANEOUS: Deletion of the gene leads to brefeldin A-sensitivity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKRYERDRSPTPDPDIVKGSYSQTSLRSLHELNYKNPAGISGLSFAGSPQQSVASLSQMRLENLVKDKHWEEVEDFGLEELRDGFFDAAFTKPDSKARSPNSDIDDDNGAARKKLQSGFTKLSEYVWTAIYRPIIHFPRDIRKNGVSIFKFFIAYFIAIVICVIRPSGRWIGHEFRYFLPIAVLIHHPVRNIGVQLEMTISSIIGASFGLGWSALAWYISTATKPTANYQGGILFQSLTMALLFAIWLRSVYRRFFYFTTSFSISIIFTHTVRLASSKFDLKWQIFWDFGISYLFGLLLSLLVCVCVSPHSGNAELMEHYNKCLQTTKTFLMALVDTELIKSKEQIYLAQVKMVKTLNIDLSQGFRDFVNQLTISRFDLQSLKSLRNSLTAMETSLRVLPIAPKIFNDDELKKMYEELEKYRSDSATLSKEASASPQSSGIPTRENTPSAFKPIGPGLLKNEIYINALKASFSKSIFNLILEMIFVLENLSRVLKKYESPNQKNNLDECVKILSHSHSKLKRKIYKLDVCYRDFVNSSFFSQELLNDEESVDIFLFLRYLRNSARQLVTVIHDCQVLGENIHWRIALPSYPLSRALTRLPKQCVLDEGAGNVLHYFEAKRDVDEIFERVYNTYTSRHKYNKGEEEALRLDSQGGDEKSQNRKNHTISIRAIDHNDFNFHTTQNPWRFKLWKLSRILSGDECKWTLKITFCMIFLCLPTWLPESYHWYQEFHCWWAPLTFYLLAHRRYSGNWALVMRRLICGIVGIFWGWAANQSRHFGSPYVVCTFAGLIVVPFSINFLVYRNTKSSFTALMCFTIIALEPYSKPNRHYNLTTAGIWKSTWVTGLALIIGILVSIPINWIVWPFRARTELRDSMSSLLAHLGQSYQTVADRYLYRDADDAPTDLTFAFSHIREVRLTQSLEAIRELLKKARHEPIIISNFNPEKYASLINSCQFLLSKIIEARISGAFFEIWDQDFDIETTRALLSLRRDSVSSVIFVFYILSNCFRSKNKIPRYLPNPIMSRKKLYHFIKKFSEMKDQSHSNLNSGGNSMEKNLFKKIYQQKASSSGQQQLPLPSVANSSEIDSEKMHWTEVHGIAFARAFTDISEALFQVESCAKDILGEENF
The following text describes a protein:
Function:
Involved in the third cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. Contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the dehydrogenation of 2'-propanoyl-CoA ester side chains of 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) to yield 3-oxo-4,17-pregnadiene-20-carboxyl-CoA (3-OPDC-CoA). Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA), 1beta-(2'-propanoyl-CoA)-3a-alpha-H- 7a-beta-methylhexahydro-4-indanone (indanone-CoA ester), hexahydroindanone and pregenenone.
Sequence:
MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHGPAYRAVIRRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLPAVTLQTVGPTLQAHGSELQKKKFLPAILAGEAHFAIGYTEPEAGTDLASLRTTAVRDGDHYIVNGQKVFTTGAHDADYIWLACRTDPNAAKHKGISILIVDTKDPGYSWTPIILADGAHHTNATYYNDVRVPVDMLVGKENDGWRLITTQLNNERVMLGPAGRFASIYDRVHAWASVPGGNGVTPIDHDDVKRALGEIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERVQRAGRLAEEIVGKYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMIAASGLKVPRVPR
The following text describes a protein:
Function:
Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Binds to the 3'-ACC-5' repeats in the light-responsive promoter (LRP) of psbD, and activates its transcription. Participates in ovule development.
Subcellular Localization:
Nucleus. Plastid, chloroplast.
Sequence:
MNIVSWKDANDEVAGGATTRREREVKEDQEETEVRATSGKTVIKKQPTSISSSSSSWMKSKDPRIVRVSRAFGGKDRHSKVCTLRGLRDRRVRLSVPTAIQLYDLQERLGVDQPSKAVDWLLDAAKEEIDELPPLPISPENFSIFNHHQSFLNLGQRPGQDPTQLGFKINGCVQKSTTTSREENDREKGENDVVYTNNHHVGSYGTYHNLEHHHHHHQHLSLQADYHSHQLHSLVPFPSQILVCPMTTSPTTTTIQSLFPSSSSAGSGTMETLDPRQMVSHFQMPLMGNSSSSSSQNISTLYSLLHGSSSNNGGRDIDNRMSSVQFNRTNSTTTANMSRHLGSERCTSRGSDHHM
The following text describes a protein:
Function:
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.
Subcellular Localization:
Secreted.
Sequence:
MKLVFYAALLTAVLAKELQLATECDPEACKLPDCRCSSTSIPGGLEPRNTPQFVTLTFDDGVNVINVETYREVLYNRVNSNNCPVRATFYVSHEYTNYQLVNELYNRGHEIALHSISHRTPPSFWAAATYDEIKEEIADQKVQIAHFANIPFEEVKGVRLPFLQMNGNTSFQVMSDFGLTYDCTWPASAQTQRGLWPYTLDYASTQDCTIPPCPTASLPGSWVVPMIAWTDPNGFPCVMVDACTSFPDREDPDAWFRFIVTNFERHYLANRAPFGFFVHEWYISAYPAVKTALVSSSDVVEWVRNPIPIAEYRSRSCKTFRQTACPASSCGPLVAEHNQLSYWLQLCNRCPAKYPWVGNPFGLN
The following text describes a protein:
Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MEDLIAQVRSHIDALVGLPVGTPLAHPPVPPASDTPIASFIDHTLLKPEATVDQIDRLCSEAERYRFASVCVNPRYVERCARALSGSAVRVCTVIGFPLGATTTKVKVFETVQAIGHGAREVDMVLAIGALRGREYHAVVDDIRAVTDAAHASGVLVKVILETGLLTDFEKVMACMLAVRAGADFVKTSTGFGPGGATVADIRLMRAAVGPTIGVKASGGVRSLAMAQELIAAGATRIGTSAGVAIVQEAEGTNLEPRNSDTY
The following text describes a protein:
Function:
Chaperone protein with functions in nuclear localization. Required for centrosome duplication and formation and function of the mitotic spindle (By similarity). In postmitotic neurons, acts with nudC downstream of dar1 to ensure correct positioning of the nuclei in primary dendrites and as a consequence, is required for determining multipolar neuron morphology.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the interphase centrosome and to the mitotic spindle.
Sequence:
MESPPMFNSVEDECRYWKERSKQYHKEWTDVKQEYDEFVEQSREMEIEMDATLDQKQSIIKDLTAKLTMFERENESLKLKLESHGIDMSNMEKQLETVKKDRDTMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALLELEVDEKGLLQEKLQRLMDETRDLKQELNVKSRFTPVVNGTSVPTANDTNTVNSSMNSSASLPNGIVANGELVKHDNAVATRATSVSVNALNGSLVNRNEYNQQHSLKSDGDETEDVPREWSANAAATPLLPAIHTSGAGRTALLLAGCRVVWILQFSVIHKPQIRNPIT
The following text describes a protein:
Function:
Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity); [ANGPTL4 N-terminal chain]: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
Sequence:
MRCAPTAGAALVLCAATAGLLSAQGRPAQPEPPRFASWDEMNLLAHGLLQLGHGLREHVERTRGQLGALERRMAACGNACQGPKGTDPKDRVPEGQAPETLQSLQTQLKAQNSKIQQLFQKVAQQQRYLSKQNLRIQNLQSQIDLLTPTHLDNGVDKTSRGKRLPKMAQLIGLTPNATRLHRPPRDCQELFQEGERHSGLFQIQPLGSPPFLVNCEMTSDGGWTVIQRRLNGSVDFNQSWEAYKDGFGDPQGEFWLGLEKMHSITGDRGSQLAVQLQDWDGNAKLLQFPIHLGGEDTAYSLQLTEPTANELGATNVSPNGLSLPFSTWDQDHDLRGDLNCAKSLSGGWWFGTCSHSNLNGQYFHSIPRQRQQRKKGIFWKTWKGRYYPLQATTLLIQPMEATAAS
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKSIGLVGDTGRMGVLLTQALLCRPHCFLGKGFSRRSQTSLEEVVTENDILVDFSSPEVTSLLLDFLLKTPRPVIIGTTGFTNDSGVKTKLSALSEYVPVVVCANTSLGAYVQKRLAAFAAKLFSTSYDVRILETHHRAKADAISGTAISLAEAIRSAKAESYEEEPEPFIEMHGSRLGNVCGEHEVSFVGEDERFVIRHEVFSRRVFSGGVLLILEKIMGEGLPKGYYTSDVLYESLFQEKVFG
The following text describes a protein:
Function:
This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Sequence:
MEDLREEILRRWESNPMLIPRVMAVTLNIAVGRSGEVLTRAGKVLEELTGQKPVERRAKRTIREFGIRKKEPIAVSVTVRGKKAVELLDRVAEAVGRRVKASSFDELGNFAFGIKEHIDIPGVKYKAEIGIFGMDVIVSIGRAGYRIARRRIERRRIPLRHRVSRAESMLFAEKYLNLKVVHEEE
The following text describes a protein:
Function:
Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to centrioles in proliferative cells and basal bodies in ciliated cells. Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Not present in the centrioles in cycling cells. Disappears during ciliogenesis; [Isoform 6]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed.
Sequence:
MEKAVNDGSHSEELFCHLKTISEKEDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKLRFPCRITESKNMNILIVLDMLCYISSEKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSDPETP
The following text describes a protein:
Function:
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
Sequence:
MSNSMINPSIVNLLEKVDDRYSLVTITSKRSRQLIDGAKPLVDIDSTKPVTVAINEIHEGKITYKTVKEGIK
The following text describes a protein:
Function:
Probable inflammasome component which mediates inflammasome-dependent resistance to bacterial infection by S.typhimurium through association with activated caspa.
Subcellular Localization:
Cytoplasm. Note=In the cytoplasm, forms a ring around specks which are large protein aggregates.
Sequence:
MGSTSFTNPYAIEVIQMKRSELVSGILNPEDLLDLLIANGVLQPDIRVLVSDLTVREEKNSRMLNILISRGERACRIFFYPCLKRAEPDLYQHMRTYVGGVNEGIRDARRQLIGYLLEKDKQGLVKNSKPERIHPKSTANEPNNEPLNKQILKSESNHHDAILEAISSGDLYLLQELTKELDVNSVLSSNDTLLHHAAEYGKEAIVYFLLRQGAKLDLKDKEGRTALHRAAQRGHTAVAVALAKAGADIHATDQTSKTPLHLAAQNGHEGCVKALVHEEKKSLKNQTTVLHMAAIEDNATLAEVLLRNGALVDAQDGQRKTALHHAVRHGNEKTAAVLLKAGAQVDSRIVDAAFQLNRKSLLSLFLQHVHESMSQTEINAALFKAVQRNLDAVVAALIEHGADVNSCNELGYTPVLLAAELGNGEAFKVLVSKKAKLDERLPNQMSSLHLAVQSGSIQIAQILLHKGIDPNISGPKDQTPLHLSASHNQPAMMALLLRVGAQLNPVTQDGFTPLHLASQNGHTEAVAQLLEAKADVHAKDKQGRTALHWAAEQGEVAIIQSLLAAGAYSNASEREKKTPLHLAAAEGHTKAVSALLAGKAKVGAKDMDGCSPLHYAARNGKERAGSVLLASSKSKNVDDKNVWRRTALHLAAEHGHEALVGILLENKAKINALDNNKDTPLHCACKTGHLGTVQRLINWTNGERANLQATNNVKKNALQVAEAGDTEAHENISTLLKKKMFLVK
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Sequence:
MSPDSCPLVKNILLLDSEGKRVAVKYYSDDWPTNAAKLSFEKYVFSKTSKTNARTEAEITLLDSNIIVYKFAQDLHFFVTGGENENELILASVLQGFFDAVALLLRSNVEKMEALENLDLIFLCLDEMVDQGVVLETDPNVIAGKVAMQSTEASGSLSEQTLTQALATAREHLARSLLT
The following text describes a protein:
Function:
Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.
Subcellular Localization:
Cytoplasm.
Sequence:
MDRETFHSCSSLVKLPRQIHQQHCSSHFIEYIEREIPYSKFFKNYLIPNQPCMFSKKFTEEWNCRKKWVTAEGKPNLQRLLHEFDETPVPVANCSVKEYNANPKQIMPFKEFIQYWRESIQNGHSSPKGCLYLKDWHMQRNFPEHNIYKTPIYFSSDWLNEYWDTIEVDDYRFVYMGPKGSWTPFHADVFRSYSWSANICGRKKWLLYPPGQEDFLRDCHGNLAYDVTAPILQDKGLYAQFEEACQPLEIIQEAGEIIFVPSGWHHQVYNLEDTISINHNWLNGCNLDIMWQFLQDELSSVQREIEEWRDTMDTWHQHCQVIMKSCTGIDYAEFASFLKTIANNRISFLNSSPRNADSCQDLLAESLCALGPHHAAFDLQRVLHIFEIMLNNEDFKRLDPATLSFKPEDLLQEIREAIRTIV
The following text describes a protein:
Function:
Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
FLETDNEGNGILRRRDIKNALYGFDIPLTPREFEKLWASYDTEGKGHITYQEFLQKLGVNYSPAVHRPCAEDYFNFMGHFTKPQQLQEEMKELQQSTEKAVAARDKLVDCYQDISKAFTKIDKSKTNYISICKMQKVLEECGCSLTEGELTNLLNSWGVSRHDNSINYLDFLRAVENSKSTGAQPKEKEESMPINFATLNPQEVVRKIQEVVESSQLALSTAFSALDKEDTGFVKSTEFGQVLKDFCHKLTDNQYHYFLRKLRIHLTPYINWKYFLQNFSCFLEETAEEWAEKMPKGPPPTSPKAMASRDILARLHKAVTSHYHAITQEFENFDTMKTNTISREEFRAVCNRNVQILTDEQFDRLWNEMPVNAKGRLKYPDFLSRFSSERAATPTATGDSAAAQRGSSVPDVSEGIRSALSLPNQELRPGSKPQSHPCTAASTTAIPGTPPLQNCDPIESRLRKRIQGCWRQLLKECKEKDVARQGDISASEFLALVEKFNLDISKEECQQLIIKYDLKNNGKFAYCDFIQSCVLLLKAKESSLMQRMKIQNAHKMKDSGAETSSFYSALLRIQPKIVHCWRPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEYYDKTLSSNISYNDFLRAFLQ
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
Sequence:
MSENQVFWLISAPNLQGADIFDLVNQKTAKENSLSENRKFNTPSLRVGTLNSLITLNDELQKIDTLVEATTKKIAKQLVDLVGTKPGKDKSLSINGATIPQYLQQFVWDDAKYNLKLSLQEIVDKISQSVSKIDDDLKLKSSEYSSLSSSVAAEERKAGGSLQVRSLNGLITQDNIVQTDYLTTAFVAVPITAEKDFLACYETLSDYVLARSAKKVAQDNEFYLYSVFLFKKFYENFKNKIGEKKWVVRDFKVESEKPTQERAKLTEEKKNYRTGLIRWCRLNFPEAFMAWIHLKVVRVFVESVLRFGIPFDFQAILMQPLKREDKKLRDILFEQFKYLGSAHISGKNEADDSEKFYPYVYIPINWEQ
The following text describes a protein:
Function:
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Required in central interneurons of the mature nervous system for correct localization of synaptic components. Required for thermotaxis.
Subcellular Localization:
Cytoplasm.
Sequence:
MVFQPIHEEEQVFVDYAIELVKKAGTLVRTAFDSPESKVDTKSSNTDLVTETDQAVEKLLIEGLSERFKGHRFIGEESVAGGAKIEWTDAPTWIIDPIDGTTNFVHRIPMIAICVGLAIKKQIRAGIVYNPITNELYLAQLGKGAFKNGFPIRASKNQLLSKGVLCQSLGLHNRVQFGDRWLDIAQSNMRNQVMAGVRGHRSFGSAAINMVMVAQGSCDGYVEYGIHAWDVAAPSIIVTEAGGVVTDPTGSPFDVMSRKVLCAGTAELGRDLSACLTHVDFEPEA
The following text describes a protein:
Function:
Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).
Miscellaneous:
MISCELLANEOUS: 'Shadoo' means 'shadow' in Japanese.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNWAPATCWALLLAAAFLCDSGAAKGGRGGARGSARGGVRGGARGASRVRVRPAQRYGAPGSSLRVAAAGAAAGAAAGAAAGLAAGSGWRRAAGPGERGLEDEEDGVPGGNGTGPGIYSYRAWTSGAGPTRGPRLCLVLGGALGALGLLRP
The following text describes a protein:
Function:
Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MCSKRELRMLMLHYSKHGECILQEIGAAFRGEHATDLLLICDGKETVRAHKLVLAAASPLIRMILEETPVLDGVTTVYFPEVQVSYFRLLLDFLYSGQVYVRSVEEYHHLQDLLALLQIKASIWKNSDGSGEGEPRKSEPLVDINRNTEGITGSSVVHQHPSRRRRSKSQDSLSGDSASGGGGTGSQAGTPKKVSVKSERHSAGSSVDGDGDRDREENLEYLDEVEEAIIKSNNNHPLHPHQHHLVAGSGGHHHHHHHHHHHRQLHQIKTRSRRSDPSANRRRSSSDPVNLSIVKQQQDVDSDDANIDVETIGTATTKTLLPPRYLDPFRTKRKAAAYYIHPADAEALKPMDHEGLLHNSPDNYVVTPHRKRRPGFHNSPAQNPPFVPSYLDDLRARSKCFLSAPPTYLPELRPGSPTSVRHAEIAAGLSNNNNSSSNNNNNNNRIRPPSADNKLAVAPFVYPWPTAALAGLPGGPSDLLGLPYVHGGGPNAETSPADLLQQMKNFENSQAELSARASAAGGGGGGSGGNGSGSGGVASGGGGGSMGGNTAVREYRCEYCGKTFGMSWNLKTHLRVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRNIINAPEAGGRYTCCFCSLVFETLQELVRHLSGHHNNLLLSKNLHE
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps; Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQLVDAFLKLAKQRSVCTWGKNKPGIGAVILKRAKALAGQSVRICKGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVKHVTITGRLCPQRGMCKSVFVMEAGEAADPTTVLCSVEELALAHYRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVAVGAKSQSLS