lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor which regulates the transcription of various genes, including those involved in innate immunity and oxidative stress responses. Binds to promoter regions of genes, probably at 5'-[GACGTCA]-3' consensus sequences. Together with transcription factor daf-19, involved in regulation of the serotonergic response of ADF neurons to pathogenic food. Modulates response to infection by the Gram-negative bacterium P.aeruginosa, acting downstream of the p38 signal transduction pathway effector serine/threonine kinase pmk-1. May act with transcription factor elt-2 to control p38 gene induction in response to bacterial infection. May be phosphorylated by pmk-1. Regulates transcription of the metallothionein gene, mtl-1, perhaps acting downstream of pmk-1.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MATTMMTSSASPPESGELDVASAVASAAAALISPMVMPTSMTNGKDMTKTSQILNEYFNMMVGKRVQLMGDTTSPFSLDTPNPKLMFTPLDLPTTAELMQRCLAVNPFEAKFREANQKISSGSMQPNTSGANQSLEALEANGGSQFSGSNAGTMSDLLLKIPQASLQHSPGIFSNMLLNAGDSEGTTRENLKTADISKLLSVAGDFSAQAPRTADVLNAVLDMHSDRLHTINYLNNKPDFSALLRSPSSSAPNSASVLTNAMAIPSTSGAPFPGTTLLVPPKTVSSYHSPLGASSQPPSTQKSPADGSWDHINGEKQIKKEIPYFNDDAMMLMERSNMSSSGSDQDQSADMSNAGSTASTSTGNPVGRPQNGTPGRGRGRGRSTTADMQPDERRNTILERNKAAAVRYRKRKKEEHDDMMGRVQAMEAEKNQLLAIQTQNQVLRRELERVTALLTERESRCVCLKGVPMSDEQHADHHHRNTNGMYSGSDMLNGLGQINGMQLKLPKLQ
The following text describes a protein:
Function:
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MITSPLLAYVAILFLCVLKASSLDTFIAAVYEHAVILPDAPLTPVSHEEALMLMNRNLDLLEGAIMSAAKQGAHIIVTPEDGVYGFFFSRESIYSYLEDIPEPHVNWIPCTNPNRFGHTPVQKRLSCLARDNSIYIVANIGDKKPCNASDPDCPHDGRYQYNTDVVFDSEGRLVARYHKQNLFLGEDQFDAPKEPEIVTFDTTFGRFGIFTCFDILFHDPAVTLVKDFQVDTILFPTAWMNVLPHLTAIEFHSAWAMGMRVNFLAANIHFPLRKMTGSGIYAPDSPRAFHYDMKTKEGKLLLSQLDSHPHRPAVNWTSYASGLPAPLVGNQEFKSIVFFDEFTFELKGVAGNYTVCQKDLCCQLSYRMLEMREDEVYALGAFDGLHTVEGSYYLQICTLLKCKTMDLHSCGDSVETASTRFEMFSLSGTFGTQYVFPEVLLSDIQLAPGEFQVSSDGRLFSLKPPSGPVLTVTLFGRLYERDSASGASADLVAQGLRVMLGVIITIMYSLSW
The following text describes a protein:
Function:
Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.
Subcellular Localization:
Mitochondrion.
Sequence:
MNRVALSTWTKRLLPILSQTSIHTQAGRGLQTGLNAVAAVEQVWSGFYRGAEGGFPLKTCADLPRRLSHTGGTELSHVEDRAGFEVKKRTGLCPDFSIDFLVALLRQENAGDICVIRVPEEMKYTDYFVVVSGSSTRHLRAMALYAIKVYKHVKRNDDPHIQIEGKDADDWMCIDFGHIVVHFMLPETRELYELEKLWTLRSYDEQLGAIPPETLPEDFTYGAAFSNEPLQ
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MPFAGAIAIAVLLLVPCAKATSGGLMIEQILSDKGCGAFAGLVATTAGVGEVFRSFLEKEAETPDVFDVFGEKRARNAGLTIFCPDDEAVAAFTPRFNKLSAYAQVALLLYHGVPSRRSEEALRLINGEEVPTLDKGPLPGSRSMLTIDVYEDIVVLSSPLPSPSVAAVTEMVVDHDRLAVYIIDDVMIPREPEIGFPALLLFFGLLALAALVLAQVLLIFGDV
The following text describes a protein:
Function:
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Sequence:
MKVPFVNFMISSFPAAVLVGAVVGFMIGRKYSVADASRGYSSKNANKASNPEKESPVSVSNDEDSESETELLDMLKGNSSLAALALAEGQTKMVLVVRTDLGMTKGKIAAQCAHAALACYKIASAVDPDLVRIWENAGQAKITLQAQTEETLELLQAQAMSLGLCARVIHDAGRTQIASGSATVLGIGPGPVSVINEVTGSLKLF
The following text describes a protein:
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAMGLIRLLSIAFTLVLLSILPLHLSLADEITSIESVPDLQKLMYVAVDGFPCVRLLNLSGEIGCSNPGINKVVAPIIKLKDVKDLVQPHTILVTADEMEDFFTRVSTDLSFASKIGGVLVESGSNFQQKLKGFSPDKRFPQAQFSPYENVEYKWNSAASSIMWRNYNFPVYLLSESGISAVHEILSKKKMKHGTYTSDVAEFNMVMETTKAGTHNSEACLQEGTCLPLGGYSVWSSLPPISVSSSNNRKPVVLTVASMDTASFFRDKSFGADSPISGLVALLGAVDALSRVDGISNLKKQLVFLVLTGETWGYLGSRRFLHELDLHSDAVAGLSNTSIETVLEIGSVGKGLSGGINTFFAHKTRVSSVTNMTLDALKIAQDSLASKNIKILSADTANPGIPPSSLMAFMRKNPQTSAVVLEDFDTNFVNKFYHSHLDDLSNINSSSVVAAASVVARTLYILASDNKDTSNSALGSIHVNASFVEELLTCLLACEPGLSCNLVKDYISPTNTCPGNYAGVILGEPSSKPYLGYVGDVSRFLWNFLADKTSVQKGNTTSVCSKGVCSKTDEVCIKAESNKEGTCVVSTTRYVPAYSTRLKYNDGAWTILPQNSSDSMGMVDPVWTESNWDTLRVHVYTVQHSAYDNAVLVAGITVTTLAYIGILAAKSIITKALKQD
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MDAAGVIGCFRDRSILITGSTGFLGKMLVEKILRVQPDVRKLYLIVRAADTASAENRVLTEIFCTGCRNKTRSKHGADFNSFITNKITALPGDIIKETCALRNSMVEQIYEEIHVIVSVAATTSLYERYDVALASNTLGVAHVCDLAKKCANLKMLLHVSTAFVAGEQEGLLVEKPLDAGKALRKDYSLDIQSELKLVESVKSKLRVQFSDDKIEKRKMKELGLKRTMDMLYVAYNDQKLQCFIFNRNVIIDVIPGDMVINALMVAMALHWEKHGTQAIYHVTSGHRNPLRGSTFLESFYEYFHSNPRVTKDGRIVKHGRVTLFKKYTFFSLYMILRYKLALEAFHVMSVFGHSLSQHYNKLNRGYKFLILIAKLYAPYAFFKGCFDDTNMKKLWAITATGELDDGSTFDCDPACIDCGSYLINTHIPAALMYASNNNQMKKAGSA
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MLSTRLGLSPLLHSSKQASSALSRLAVPRTTSTPLPRRRLTIVPSATPRRSFCSSHTADDKDRSKKDITMYLQETHDKVFENNKSWAAEQVAKDPDFFKKLAAGQNPEYLWIGCSDSRIPAEQITGLQPGDAFVHRNIANLVCNTDLNVMSVIEYAVKHLQVKHIVVCGHYGCGGVKAAMTPKDLGLMNPWLRNIRDVYRLHEKELDAIADEEARYERLVELNVYEQCRNVVKTAALQQSYAENGFPIIHGWVFNFRDGMLKDLNVDFKTILKDIQKIYNLTN
The following text describes a protein:
Function:
Involved in growth, and during development, in aggregation.
Sequence:
MDLEQDEWMSQRQRQQQMEFSRIGIEVIGSKKDLIVNSMKNHETTLTIINETYRIVYYDQYESKFTSCNIITFDGKDKRSIKKMKRVVQKLSNESTNSSHQFDLHSHALLQSSSSSSSSSTSSSPSLTSSPSSPISTSPPYHSSPQLLEHLLHQQQPITSVGSKPSFFVIINLYNDDRQSYMSEIVSFAGSFQFIEWRNDESWKEVFKLSSNLLTYHVKKNELARACTLGDINLLDEIILSGCSKSQLKEAQGAGYTIVFNSYTSYSSGSSLVVSGTMALLCAIVENGTFLLLSKSNITRFPMSIINMCSQLVELDMSNNRITEIPIEITELKFLKNLNLSDNLINDIPLEICNLTLLKVLLLNENPLNNFPSSIVELGTKKLLSFCRNILEGKSCETWNKVKLMFVGEEGVGKTRLCKLLIGSKYNKKKSSSSSSSSLSSLSSALSSSSSSSSIINSNSISNSNINMVNIKNENQVTGDTVSTEGVNIHDFKSKKVEFYAWDFGGQQIFYPTHQFFLTTQSLYLLIFRVNDSNFAERVNYWVHQIKAKSGISLPIIFFVGTHIDSCTPEQLSMAESILKSNFIKYSRVKQNVINFVSCVTGKGVKELKKRLIHESEKSRLIKKDIPGSYIILEQRLSNRGANQGRMSISNSASNSSSSLLNSSSSSSPSLTSKKSSSHLKHSQQQQQQHQQQQQQLQQSIKEKYIDYDDYLNECKLSYLKPHEIKDATDFLHNLGIILHFDSPKLNNLVVLDPQWLADVMSSLITFSHSWIKLGILNHSDLQSIWGGRYKQTLWPSLLKLLEKFEVSYQLPNLSKSLIPSLLPDDPIGEILEIKDREWVPLKLAMENNYVQVFGCDYHFSFMPLGFFARLLLRILLIQGIDIKTYWKDGVLLDILTPSDKIKQQQLLQKKSIFEPTTTLSPFLCSLSLTDSQNYSPLEPPPLILNSPRVNRKFISNSTSTTSTTTSTTSTSTTSSNNITPLSMSSITPYSPTSPRTPSFSSSSTTTSSSSSSSSPSSQFCGVGCHRNINKNNGSSNELIKTLTKINNQNGSSGELIKTTTTTSTSTSTTSTTTPTTTTPTIPIKNNNNKKLPINRTVSSLCLTAKPKLQALITFIKKKSFEQSHDNDSYKLNIQVRTYNTTIDKEHSVSLFFQQLLFTIDTLISGSYQGLEVTRTIPCTHCIQLNPTIEPYHFDLGDCISALEDGRSHVYCGNDPNTPVRIDYIAPDICLKKVPTFTDDQILYERQIGEGGFGLIHKGKLISNKSDIAIKSLILCNSNNNNNSNNNNNSNNSNNFKNNNNEDEFIEKFQEFQHEVFIMSNLNHPNIVKLYGLMHNPPRMVMEYVEHGDLYHLCQDKERYASLGWTLKLRLMIDIAKGIGYMQNQNPPIVHRDLRSPNIFLKSLDENSPVCAKIADFGLSQQSVYSVSGLLGNFQWMAPETIGVEDESYTEKVDTYSFAMILFTILTGEIPFDEYSFGKMQFINLIREENLRPTLPFDCDPRLSNLIQLCWSTNPKKRPSFTFIIKELLEIRIDSIQTSYFDSPFLKNYPASI
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLTTVARTLRGARSITWRSLSTTSPVSASLDRGYDITTNKPIDFSKPMYCERREYPLPDVPYVSDLTPQQKALKQKENGPWNQLTKEEKLALYHISFNQSYAEMHSGSKSEWKTIVGAVLYFLAFGGLYLWWHRIYVYGPVPHTLSEDWVAMQAKRMIDMRVNPVSGFSSHWDYEKKQWK
The following text describes a protein:
Function:
May act as a formate transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASSFKSPADTAKACVGVAALKEKAPLSNLIVLSFVAGAYIAFGGLLAEVATGGMAAAGWPTGLVKLVFGGVFPVGLMLVVIAGSELFTGNCMYMPMGILQGEASVMGTIKNWVGSWVFNLVGALFVAYVLAYLTGILTAEPWAATAVTIAKTKALGGAQFIAAGKTVTSLSWMQVFWRAIGCNWLVCLAVYLAVASDDVIGKSFGIWFPIMAFVCIGFEHVVANMFFIPVGIFIGGVTWSQFFINNMIPATLGNIVGGAIFVGCIYWFTYLRGTNKAKA
The following text describes a protein:
Function:
Required for the expression of the mitochondrial gene for cytochrome c oxidase subunit III (COX3).
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MHLKKGKRSISTVWRLLWKRFYSVNSKTNMHFSRSRKKPVTNFTRTNGLLLSCNGDTFPYLRTLWRYFNAPGNLMFVTTNIVAFMGIVTYNTLVTISSERAFEEQMMAAQVSLAKQREELETTALSLPRDIELRGEEDDIKWEQPDVAHVREDPLVEEQNAKLDTPIKQYTLGDLILNKRENVTDYDSQRAKASIFHMLYAYMLYRDVIQPTTMTQNNNSEEWRREVELLTKGKEVQGTHRRIDVFYDLWNKNFDKIVTSPEKVQNFQLPNWSKYPTILKFICTELHDNSLKTLGEFKQFYGKVRSNEVKKLLGLWLYDHSFLFPHNIYDNRTEEDFYDILINDSMQDNRIFQKYSSIVMNPYNERTQLFFPNVNSPSVNKPVPSISLETYTRLLKGYINLQETGCKYDYNDNIFKLISILKLNCFLQRNKKKHAGPTVRILLPRDEDRSQILGTISQAEKRTCYQILSKNRDVVALLKRISDIQADSS
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endomembrane system. Membrane; Multi-pass membrane protein.
Sequence:
MTNSTWVIIRASLETVGKLVLVGLCGYVSAKRGFLTKPALAALSKVTFTFPMFCTIVTRLSSSVDNPKDILNWWPLLVSCFSLIAIAAFFMRGIAFVSKMNTKDSRVFVHTFSFGNPTVIALAIIDSLTTDTTLFGEGAAAQQAKKRGSAYISTHLFMFSLLFWILGYIYINLNKTNDEDTLPLVQPSEPSKESLNDHKNDDKPTEEIFEEIPHWYDPIINSIKFVWNFIIKIWDIFTSFVSKQWNRLPKMVREIISKLFNPAFLAVFFGMLFLFVKPLYNFFFTGPLRIVGNTMKVLDQATVPLCLMIVGANMARGPVASGVSPWTIMSGIVMKYAILPFAFVSVIYLCYLYNVFIDDPVFVLIMCIESATPPVFNTIVLCTLAYPKGNKLVASLTFWGYLIDIITLTVVVAVTLLLIQDDLNVN
The following text describes a protein:
Function:
May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVRPGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGDLSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDNWSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS
The following text describes a protein:
Function:
Involved in autophagic vesicle formation.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MQVAEYSSLIDSTIKRKVIEGTIPLIVRIPFKNEEKFTLYNASRNEYLPFLLKSSLTEFLEEVEQPISSVTYTVNEQNVKWYFPIGVIFDALHNGSLPMEITIGISQNQSTFQPYENEETIKNYHIQQLKESVYLRYGSIQTIRQLAVESITPLWEFHAQNKLEEYEQLLNPILITGENWQNIPIHWYFGSQRRYTDCIPVIINDHLTTLIEGLQVFLKERDINDNDPPSLQLLKTNSFEQCPNLCIVIQGITIPLDTPLLWLALNLSHSDLFLHVIIRKTDELLIVI
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRLRCKARSGSFALPGLTAHSRLRELQAVIAALTGVPAQAQRLLLGFPPRDVDLSDGEQRLGELGIHSGDTLIVEEDATKPKTEPAIVTKRTASNSFREALPVLARKVVPADNSCLFTSIYYVVEGGVYDPGCAPEMRNLIAQIVASDPESYSEAVLGKTNQEYCEWIRREDTWGGAIEVSILSKFYQCEICVVDTQTVRIDRFGEDAGYAKRVLLIYDGIHYDPLERKIPNSDVPPQTIFSASDDIVLAQAMELADEARRKRQFTDVNRFTLRCMVCQKGLTGQVEAREHAKETGHTNFGEV
The following text describes a protein:
Function:
Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm. Golgi apparatus. Note=Shows dynamic localization in developing spermatozoa. Localizes to the manchette in step 10-12 elongating spermatids. Detected in the basal body and neck area of step 13-14 spermatids. Localizes to the midpiece of the sperm tail in step 15-16 spermatids. During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece. Detected in the Golgi apparatus of late spermatocytes and round spermatids. Detected in the cytoplasm of Sertoli cells.
Sequence:
MSEILCQWLNQELKVSRTVSPKSFAKTFSNGYLIGEVLFKFELQSDFSEFSESRVSTAKLNNFSRLQPTLHLLGVQFDQNVAQSIITEKPGAATKLLYQLYIALQKKKKTGLTGLEIQTMQPQTNQRLQALKSEAFRERLKNLIPRQTDFNLMRVTCRFQEKCKQMKEDLARMHFEKFEKIQKLEEEQRHFNIEKQRLNRRRQNEIMAKIQAAIIQIPKPEPNRTLKAIEAQKLMKKKKEAEDVANEIKKFEALIKKDLQTRESISKTSLDTIDQTAAELLNTYSDDDYIKKIQKRLEEDAFAREQREKRRRRLLMDQLIAHEAQEEAYREEQLIHRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQFEERRLKDFQDALDREAALTKQAKIDFAEQTLRAKEIHEKIAMERAQQRYEKHYGICAEILDQILDLCTKVADYRLLTNNLIPHKMMRDWKELFFSGNPIYEQTSHTHGQTESTEDHHVELNKRNLLDSKDYEDYKNMTGEWALPEDMANSSPPSNNNILGHVLLRLIENSYPSEKEVADTELPSFAVKGCLLGKTLSGKTTILKALQNDIPIQVLSIDTLVQEAIQAFNDGEKSSKAPSMHEDVKGDPEVDQKEMIIPQDKNELTDTQVPGEAAPQKEGTKSSDFEQFRPSNSFLSLSMRAQLGAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTGYKRKSLQLKKKKAQMPTLALSPTTSKEVPFLPSAFDFAILLDISDNSSLARINDIIAKEISHEISHENVSGPTITSSEEKSEDRNLRDHIQHRIVGFLDNWPLLEEWFTEPRNILKKVNAEIDEAFLCQKIKEIFATEVSNKKIKVEKKLEEKETEKKSAVSPTEPPTPTPPLASEAEKEKEVHQAKPSGKGKTQSVSPKGKAQGGKISVKKSPIDSTEVSPTLIAMPTTKPGSEEWVYVTEPIPEELPSFLVPYWELIEKTYISHIKTVLRQLRESQHTVLSYLYETRTSFQEFLRRPDHKQDFVSQWQADFNSVPEDLWEDEETKAELHQRVNDLRDRLWDICEARKEEAEQERLDIINESWLQDYIGITMNHFFSLMQAEVNRFQDTKRLLQDYYRAMESRIPLEDNKKFTRIPLVQLDGKEISEHQLRIPLVPRISSSPENVSMRPKVKALLKGRFDPPLESLEANFEGDEKIVLDTWQQASLAISQMVAAEVHQRLAEEEKEQPQLDPKEKSPQSGTNKKAKKEKEQAKKEKEQAKKEKEQAKKEKEPPKKKMAEKKGKGKSSPVVEVSPVTITPEEMAEMERKNELKLKIKEEHLAALQTEEQATQFRLELIKSKALSILEDLVTKVIEVYRFMEKWLGKRYLNEMASIQKLTEVARYHIETATKIQNEIYLSQEDFYINGDIKVFPDPPPPTRPPPVEKEENGTLTIEQLDNLRDQFLDMAPKGIIGNKAFTDILLDLVTLNLGTNNLSSSWMHLTQLDLQEITSLLTVNTEFVDWRKFLMVAAMPWPIPLEEELLETLQRFKATDEAQTGTITFEQYKQAGLWFSGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADSEKDPPQLDYTQMLLYFACHPDTLEGVYRALSVAVGTHIFRQVETPMLTAEKTSISSVSPNEEFPEAEENSTREELKEEKDERDQKEEEIPENANTEKISMETLLKVFGGGNEVLDANRFASYLKTENIYSENLIKTFQDLGAKNLEPIEVNILLKHPYIQDLITNYVDYKIPDIKMILQRSEHAQGSDGERSPSRLTDEKK
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of L-arginine to agmatine. Is also able to decarboxylate L-canavanine, although less efficiently. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.
Miscellaneous:
MISCELLANEOUS: A chimeric protein containing the beta subunit of SSO0536 and the alpha subunit of SSO0585 (SpeH) has ArgDC activity and no AdoMetDC activity, implicating residues responsible for substrate specificity in the beta subunit. But additional factors in the alpha subunit are required for efficient cleavage and turnover.
Sequence:
MSEREVLQKINSPEGKEDRIIGKHVFGNLYDIDAERLNDKEFLEKLVLEAVDIAHMKLVEIKAWSFGGKKGGVSVIALVEESHIALHTWNEYNYATLDVYTCGEDSDPQSAFAHIVNALNPKRYQMFYADRSSQ
The following text describes a protein:
Function:
Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate) and methanopterin (with alpha-ketoglutarate).
Subcellular Localization:
Cytoplasm.
Sequence:
MILKPENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGNINPKPDIKIVKESPATAVIDGDLGLGQVVGKKAMELAIKKAKNVGVGVVATRNANHFGIAGYYSELAMNQDMIGITITNTEPAMAPFGGKEKILGTNPIAIAFKGNKYKFSLDMATASIARGKILEALRKKIKIPEGCAVDKDGKPTTDPAKALEGCILPFGGPKGYGLALAIEMLSAIGGAEVGTKVKGTANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPAEGFEILIPGEIEERNKMKRKDGFEIDKNLYNQLKEICNELGLNIEDYIE
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVKKSKIVIFFLVVAIIFGAVFGTAKMVMQNINLGLDLQGGFEVLYEVSPADGKGTVSKQTLTDTVTSLDKRVNSLGVAEPSIQIEGNNRIRVQLAGVTDQAEARKMLSTTAQLSFRDANDKMMMNGSDLVAGGAKQAFDSSNNPIVTLKLKSADKFASVTKTILAEAPDNQLVIWLDWKEGQKYKTEREKKDPAYLSAPNVSSVLDTDKVEISGSFTTEEAKDLAELLNSGALPVKMKEVYSTSVGAQFGQDALQETILAGIIGVIAIFIFMMAVYRLPGVIASITLVAYTYLVLLILSLLNATLTLPGIAGLILGIGMAVDANVITYERIKEEIKVGRSTKAAFEVGGKEAFRAILDGNLTTLIVAAVLFYFGTSSIKGFATVLIISILVSFLTAVWGSRFLLGLLVKSNWLNNKPGFFAVKRKDIHNLHEGINSFSLKTHFDRFDFVKHHRLFLSIFAAIVIVGIVILSIFRLNLGIDFASGTRAEVTANQTLTETQIKKDLDTIDMPSDDIVFQGSGSKTAVVSYKGTLSQNDVAKFKNYFEDKYKHEPSISTVSPTVGKELAKNGFWALGVASVLIVLYIAVRFEFYMGIAAILSLLFDAFIIFIFFSVTRLEVDLTFIAAVLTVIGYSINDTIVTADRIRDISMKMQRFKTKEEIADAVNKALRQTFTRSINTILTVIFTVLALVLFGSESILNFSIALLVGLVSSVFSSIFMAMQLWYVFKARQLRKKGPISTVKKKKPRNNGQPVV
The following text describes a protein:
Function:
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLIVKTFQEITIKSRPVRKRFIRQLAKNIRAVLRDLDPELKVEGEWDNLEVETAVVDAKARREMIERLTCTPGIGHFLEVHEYPLGDFDDILAKCKAHFGDQLAGKTFAVRCKRAGKHAFTSMEVERYVGSGLRRECGAAGIDLKQPEVEVRMEIRLDRLFVIHRQHPGLGGYPLGALEQVLVLMSGGFDSTVAAYQMMRRGMISHFVFFNLGGRAHELGVMEVAHYLWEKYGRSQRVLFVSVPFEEVVGEILTKVDDSYMGVTLKRMMLRAASRVAERLELDALVTGEAISQVSSQTLPNLSVIDRVTDTLVLRPLIVSHKQDIIDTARQIGTAEFARHMPEYCGVISVNPTTQAKPYRVEHEESKFDMAVLERALERATQRTVDRVIDELGQDLQVEEVGEVLPGQIVIDIRHPDAQEDEPLALEGVEVQALPFYAINSRFKELDANRQYLLYCDKGVMSRLHAHHLLNEGHTNVRVYRPA
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MENLEQTCASLRAQIAATEAQLAGLKRELEIAEQAAEVKAQSTTRTITAEDGKTNETREWPLLSEEYKRYGRQMIVPQLGLQGQLKLRAARVLIVGAGGLGCPAALYLAGAGVGTLGLVDGDTVENSNLHRQVLHRSKNVGTFKVDSAIEYLRELNPHPTYVPYRAHLTPQEAPGIFKDYDIVLDCTDNPATRYLISDTAVLLGKPLVSASALRTEGQLMVLNYPPRPVGDKSGGPCYRCVFPKPPPANSVVSCADGGILGPVVGTMGVLQALEAIKVITSPAVNPSASPPSLLIFSAYSTPLFRTIRLRARRANCAVCSADASVTLETLKNGSTDYVFFCGVAGLEATLSPEERISPLEFKKRHPKEVPQDGGRINKEPTIIDVREKVQFDICSLENSINIPISTILSSASSPTNVDANAQPSLPFWLPRELASADSTDPIYVVCRHGNDSQIAVRRLKELGLDRGGQRYVGDIQGGLRAWREQIDPDWPEY
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). May play a role in the regulation of cell morphology, ER morphology and cytoskeletal organization (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSTRRSSTRADSTTKRPASPNSTPNAALGIFVAIARQILFIDARKVALFYLAFVTVLSFIESRIELDSTYYLVQKHSVLNQYGVKMGWFWTLVIVGPFIWFSSKAHNRRDRDQPIVDVCRLGVGTACWYFSVQFFHKVLALTSMCDKGRTLTRAQCSEKEGVWTPGYDISGHCFLMIYSILIITEEAIAYRHYQQVTDAVHQMDGDREEHDRLTRCIQYFFVAMLFLHAFWFKQIIISVLYYHIFIEEILGAVAAVVCWFVTYRMLYPAGFLASPIRRTVGRK
The following text describes a protein:
Function:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (By similarity). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (By similarity). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cell membrane. Cell junction, tight junction. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated is retained in the cytoplasm by YWHAZ. Can be retained in the nucleus by MED15 (By similarity). Localized in the cytoplasm in areas of epithelial cell high density. At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass. In the nucleus, phosphorylation by PRP4K induces nuclear exclusion (By similarity). Interaction with AMOTL2 results in localization to the cytoplasm and tight junctions (By similarity).
Domain:
The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes; Binds to transcription factors via its WW domain.
Sequence:
MNPSSVPHPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGGPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKVMNQPLNHVNLHPSITSTSVPQRSMAVSQPNLAMNHQHQQVVATSLSPQNHPTQNQPTGLMSVPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMETETMAPVNTPAMSTDMRSVTNSSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNMDEMDTGENSGQTPMTVNPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL