lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.
Subcellular Localization:
Cell projection, cilium, flagellum. Note=Localizes to cortex of the fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Sequence:
MEECEEPEEPISLGRQEYRRRRRPSQPMVDKSQQTEITEKRKAMASVQPPAPKATHSIGNIPGSKDNYSRKEYESLRLSSQLQKTLMKRKHVQDMTDKSLQTEPIVEEKVEVIFIDKTLKLEENTAGVGEIAPELPQSIPEVEIPTSRPTSHLIDRSQQTSCTGDWSLIYICPKEKVDKEQQTYFSELEIIIRSIPGSSMTKSKEETIPIAQEDPLVEINGSLEIEVLSPEELPDVMMSFTEGEISGELQALSNGEATVKGELFLTEEIPIQAPSPAEETSAAETATTTAKDVVDIQAPPADKLSSVEAPADISPTLVQGALSDKPSDQQYPQGTEMAPSELPVEDLDPFSEEVLEKVQALTTDSMLEDLGIAESTIAEETSGKVQHPLSEETSKEVPAEVHFPIAADFEESAILINEKFATDEVFEEYKPPIIEEVSADKATAEVQPPSAEDASEEVASSEVLPPSTEQGTVEDLTAEVLSTPTEEGPTEVPPQPTEEGPAEVPPPLSEEGPAEVPPAPAEEAPAEVLPPPAEEAPAEVPPPLTEEGPAEVPPPLTEEGPAEVPLAPAEEVPAEFLPPPAEEVPAEVPPPLTEEGPAEVPPPLTEEGPEEVPPLPAEEAPTKVPPSPAEKGSAEVSPPQTEEGPAEVPPPPAEEFPTEVPSSSAEEGSSEVPLPPTAERPEEAPPPATEEAPVEVLPPATEEAPVEVLPPATEEAPVEVQSPAAEEGLAEVPPPPTEESPTHDVPTEVQVPQAKESPGQVLPLSGESTAEEASAQVQPPSFEKAPLESLPLEEVEKIHLDNLPFEVQPLPTEDIAIGVPAESQALPADENPAREDTVETQPSSFEGAPIAENPIEAPLPASEADTGREDSAVHPSSLGPTDEAPAEIQILQTDDIPTEMSPVENQPLPAEEGFPEVVSEEEATAAEVRFPLSEGAPAQEATVEAQLTSVEESPKRASVDVQPLSPETPVEESPGVDLPLKTNEVTMQEFRVEKMPAEDSLPPSEQTPADQVLLKEHRLSQVADISEKELESTTLTSDKMSEGIDSVPEDVSGTKDDQISTFKIEGTIKIELKN
The following text describes a protein:
Function:
May contribute to UTP accumulation needed for blast transformation and proliferation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAVCGDGRDSAMECGEKSSARCTSGGAEDSLDRLLPTVNTSLSPRKRTTSQCKSEPPLLRTSKRTIYTAGRPPWYNEHGTQSKEAFVIGLCGGSASGKTTVARKIIEALDVPWVVLLSMDSFYKVLTSEQQLQAASNDYNFDHPDAFDFVLLVHTLRKLKQGKSVKIPVYDFTTHGRQKEWKTVYGASVIIFEGIMSFADKELLKLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQYNKFVKPAFEQYIEPTMRLADIVVPRGGGNMVAIDLIVQHVHSQLEERKLRWDMAALASAHQAQPLPQTLSVLESTPQVRGMHTIIRNKDTNRDEFIFYSKRLMRLLIERALSFLPSQVHIVQTPQGEDYEGRIFHGKRITGVSILRAGETMEPALRAVCKDVRIGKILIQTNQDTGEPELHYLRLPKDISEDHVILMDCTVSTGAAAMMAIRVLLDHDVQEEKILLVSLLMAEMGVHSVAYAFPQVKIITTAVDKKVNDLFHIIPGIGNFGDRYFGTDAPTDWSDDDMDEPSC
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
KMPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSGEDPLVKGIPEDKNPFKEKGSCVIS
The following text describes a protein:
Function:
Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSFTCISCRVAFASADLQRAHYKSDWHRYNLKRKVAELPPVTAENFQQRVMAQKAQVAESERETCSQCAICKKFFNTQNAFENHMKSKKHKETEAKQVQKIQSEVEKQNQKNREKGYDVAHERAQKDTVNKALAEARKSPGPVKRKVNSLDPAKVEAIRQLRGRGHRSSQRSRSQPDDEDEGEWEDEDEEEVIGGDEEMEIEDSSEEEVDYPGTPLTEKQCLFCAREGDSLDNNMQHMTVEHSFYIPDVEYLADLEGLIRYLVESMSSFTCISCRVAFASADLQRAHYKSDWHRYNLKRKVAELPPVTAENFQQRVMAQKAQVAESERETCSQCAICKKFFNTQNAFENHMKSKKHKETEAKQVQKIQSEVEKQNQKNREKGYDVAHERAQKDTVNKALAEARKSPGPVKRKVNSLDPAKVEAIRQLRGRGHRSSQRSRSQPDDEDEGEWEDEDEEEVIGGDEEMEIEDSSEEEVDYPGTPLTEKQCLFCAREGDSLDNNMQHMTVEHSFYIPDVEYLADLEGLIRYLGEKVGGAFFCLYCNEKGRTFYSLEAAQGHMRDKGHTKMLMEGEAMLEYADFYDFRKSYPDYQAEGAAGGEEEEEEPVEKEELRVTDDETQLVLPSGSRIGHRALQRYWRQNLIPSMSHRTSGREAVGRLMAQYKALGWKGDYGEAAQKKVRDMQFVQKLKSKQRMQMGVRSNKFQTHFRPQVVF
The following text describes a protein:
Function:
Catalyzes the transfer of beta-galactose from UDP-galactose to position 4 of alpha-1,6-linked fucose at the reducing end GlcNAc in N-glycan cores. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Localizes to vesicles or organelles in coelomocytes.
Sequence:
MPRITASKIVLLIALSFCITVIYHFPIATRSSKEYDEYGNEYENVASIESDIKNVRRLLDEVPDPSQNRLQFLKLDEHAFAFSAYTDDRNGNMGYKYVRVLMFITSQDNFSCEINGRKSTDVSLYEFSENHKMKWQMFILNCKLPDGIDFNNVSSVKVIRSTTKQFVDVPIRYRIQDEKIITPDEYDYKMSICVPALFGNGYDAKRIVEFIELNTLQGIEKIYIYTNQKELDGSMKKTLKYYSDNHKITLIDYTLPFREDGVWYHGQLATVTDCLLRNTGITKYTFFNDFDEFFVPVIKSRTLFETISGLFEDPTIGSQRTALKYINAKIKSAPYSLKNIVSEKRIETRFTKCVVRPEMVFEQGIHHTSRVIQDNYKTVSHGGSLLRVYHYKDKKYCCEDESLLKKRHGDQLREKFDSVVGLLDL
The following text describes a protein:
Function:
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
Subcellular Localization:
Secreted. Bacterial flagellum.
Sequence:
MAGTISDYGGRQQIWNLGNNIIDTKKLVDLELQALEMKKSPYTTQKQTLTNEKNVYASMKKEFGNLVQVFKDLYAFKGDEKKTTLSKDGFMKAQADAAAIPGTYTITVERVAERHQITTAPLTPSKTPESMEQKFSLDLKLGVDDVFQINGKEVKISKDMTYKDLVNKINNGNYGASVYTLGDQLFFTSTTAGEAGELKLTDGANGFLQNIGLVTSAKNPDGTNVVAHQVTGAINAEYTINGIKGTSKTNKIDTIPGLTINLEKETTEPIKLTIEDSDIKNSIDLIKKMKDEYNKAVKSLDLFAGENGVMQGSNVSFAINNAMTGIFKFSQDDKYLFSFGIQIDKKGNMTLDEEKLKTAFKENPESTKQFFFGLNGLGHDTEKKLDGIFGDEGIIGKRSKSIEKQVTDLERKIQDIDTVNKEKQKTIIDKYAKLESQLALLDSQLKTIQAMTKTKSDD
The following text describes a protein:
Function:
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (By similarity). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDAHVAFSGFPTLPSVSPSGPQPPSLAGDEPGREPEEVVGGGDSEPPAAPGPGRRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRFKRTELPAPPPPPFPYAPFPPAPAPAPAPPARLFRLDSLLGLQTEPPGPLAPEPPCCAAPDASFPPCAAAASPPLYSPAPERLGLPAPLPAEPLLALAGSAGALGPLGAGEAYLRQPGFPPGLERYL
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MAAPSPALLIYILVVLVATAATAQCRPQKHHGQASKTAFAPLATVHAICSNTPHPASCLASAAVHLDAATAHLLASSITVPLLPANILSVALASLRGALSAVSSLSPFLSSTLSAPSSSTTPLRRGAAQDCLELHDATLSSLSRSASLLASPGEGLPSVRAHLSAALTNKATCLDGLAGSSGPRMDGLLASLDDAYEHVSNSLSLVARSGGGGSAASFQATVAKIIHHNRRLLQDDEDSDGDDDDNSRNGNGDDDDNNSRDGNGDANDSGETVITVAKDGSGNFRTVGEAVAAAPNNSDARTVIHVKAGTYVENVEVPPYKTNIALVGEGRDVTVITGSRSAADGWTTFRTATVGVSGEGFLARDIAFRNTAGAARGQAVALRVNADMAAAYRCAVDGHQDALYAHSFRQFYRECALSGTVDLAFGNAAAVLQACALVAGAPVPGQSNVLTAQSRGDPNQDTGFAVHNCTVEASPELLASGVGTRTFLGRPWGAYARAVVIESYLGPLVDRDGWTGWPGAEPGRADTVYFGEYGNEGPGAGTDGRVGWAGFHEMDYDEAAQFAVDKFIYGDDWLATTSFPYDQGI
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MWSDPIADMLTRIRNANMVFKEYTDIPASNLKKKICEILKREGFIADYKYIEDGKQGILRVYLKYKGGRKNRERVIHGIVRVSHAGRRIYVDKDHIPKVKNGLGIAILTTSKGVLTDKEARQLGVGGEVIAYVW
The following text describes a protein:
Function:
Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSQGDTTSGTQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCAYFERPDMTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEYDVNVIGLTLSENQYAHDKAMFDEVDSPRRKEVRIQGWEEFDEPVDRIVSLGAFEHFADGAGDAGFERYDTFFKKFYNLTPDDGRMLLHTITIPDKEEAQELGLTSPMSLLRFIKFILTEIFPGGRLPRISQVDYYSSNAGWKVERYHRIGANYVPTLNAWADALQAHKDEAIALKGQETYDIYMHYLRGCSDLFRDKYTDVCQFTLVK
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. Required for embryonic anterior-posterior axis formation.
Subcellular Localization:
Nucleus.
Sequence:
MSMLRRPLTQLELCEDDIQWLTDQLNKRVLPAVIVPKCEMMDIDEMEPMDQSEPPRGITRRNLRSADRKNRDVPGPSTGECTRTSIAPTLTSARTPVAAPTLTLSTPVNPVSSAEMLRVMPPRVGRRPRASRSGDNDSPLLFNAYDTPQQGINDESPTPSDSPESPNAHLYGATPGNPTSTSGGPSSNTRSHRH
The following text describes a protein:
Function:
Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against the Gram-negative bacterium E.coli K12 and Gram-positive bacterium M.luteus NCT C2665.
Subcellular Localization:
Secreted.
Sequence:
AIMDTIKDTAKTVAVGLLNKLKCKITGC
The following text describes a protein:
Function:
Molecular chaperone that functions in the processing and transport of secreted proteins. Required for the synthesis of lipophosphoglycan (LPG), a cell surface glycoconjugate. Necessary for the attachment of the galactosyl residue to the mannose within the phosphoglycan repeats of the nascent LPG chain. Also required for addition of phosphoglycan to acid phosphatase. Not required for normal growth. Has ATPase activity. Binds heparin with micromolar affinity which may facilitate infection of host cells.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MANSSLLRVVLVALLLLGSVTVSAGDGRGTPIAFQAEVSKMLDILVNSLYTNRAVFLRELISNGSDALDKIRVLYLTSPKEPLTKDGEAPTMDLRISFDKEKSELILRDGGVGMTKEELAKHLGSLGTSGTKHFLEKLQEGVGAGGGDQNNLIGQFGVGFYSVFLVGDRVRVASKSDDSDEQYVWESKGDGQYFLYPDPRGNTLGRGTEITIELKPDAEQFLSAETIKKTIHQYSEFINFPIYVQEEVEVASTAATPEPAAEEGSLDEGAVEEDSDKEGGTQGVAKERRWVLVNENRPIWTRPIGNVTEEEYHKFYKAFSGDYRDPLYFSHFKVEGEVDFDSILFVPTTVDPASFSDDNAAPNTNIKLYVRRVFITDEFRDLLPRYLNFVKGIVDSNDLPLNVSREVLQESRILRVIKKKLVRKTLSMFADIAAQDEAIADGKQVENPALSGHTHLKKPAYTKFWELYGKHLRLGVMLDSNNRNRLTKLFRYKSSRSESEYISLQTYVDRMKKGQKGIYYLSGDSVARIKKSPVLEDAVNHDVEVIFMTDAIDEYVVSQLTDFAGKKLINLAKEGVQFEESDARQRVADRKRKEKYDSFFTHLRVLFGYSEVRKVILTKRMTNEAFIVSSGENQITARLASIMRGQSMSLANQQMTAERVLEVNYRHPLVDEMFKRFTVDENDEVATDIAWVLYDTANLQAEFPVADVAAYSKRINRLLRSSVDLSADDSLLPPDDAEYTVSDTEAEEEEEQPKVDANADEKAEAVDEGDL
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MISSNNKRRQLIALAVFSILLFLGCTWSITSGEYNIPVERFFKTLIGQGDAIDELILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAIALFIAIGKINADNFVYVLPLISILGGITTALIIFIFSFNKNEGVTPASMVLIGVGLQTALYGGSITIMSKFDDKQSDFIAAWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFLYLMYKTKNV
The following text describes a protein:
Function:
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
Sequence:
MRTVGVEEELLLVDPATGEPRALSAAVLARAFLDDSEQDVFEKELHEQMLEFATHPQADMERLHAEIVRCREEAGRHAGGIGCAVAALATSPLPVTPSIGVNRRYEWMAEQYGVVVHEQLVLGCHVHVSVDSDEEGVAVIDRVRPWLPVLAALSANSPFWQGRDSSYSSYRSRVWQRWPSAGPTELFGSAERYHRRVADMLATGTVLDDGMVYFDVRLSQRYPTVEFRVADVCLDASTAVVLAALARALVDTAAREWRAGAEPAEHSVSLLRLAAWRAARSGLTSELLHPATMRRMPAESVVRDLLEHAGEALAAAGDLERVREGVEKLLRHGNGARVQRELLARTGSLREVVAACVRRTQAA
The following text describes a protein:
Function:
Part of a potassium transport system.
Sequence:
MYVIIMGAGRVGYLVAKMLEEDGHDVTIIEMDRDRAKELSLMINGLVIEGDATDTKTLEEANIKQADAFAALTGRDDANLLACILAKSLNPNIKTSLRVSNPKNRRIFEEVKDLKKYFDFVISPEEIAAEYISRNIVTPGFDRVLFPKEGAEIVRFTIDENSKVAGKLVKDLNLPRDALIVAIYDGKGNLIIPSGDTKLPEKGQIIIFAKNSALKEVKELFEDRKEESE
The following text describes a protein:
Function:
Tethering factor required for histone deacetylase HST1-mediated repression. Probably involved in targeting HST1 to a subset of SUM1-regulated genes.
Miscellaneous:
MISCELLANEOUS: Present with 861 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSTNTEIIKNSDLQSLINDKRRLINEIKDFNKSIKPLEFESYQDYFLIKTFKKGISASGHVDIDSLRNKEYGIYYKKIKRNSTQEVGEPIPRNTSSSSSSTRSNSSADISDTEYSGENTPTTTGAASRRRRTRSRAIQRENSLPASLPSISEANANNDDVTISEINGSELPFPIPISEVENIDIASDITERDGIRRRSSRISERDKRRSQSRLGSEEDEEGDGHDGDEGETKIQDLYESLVPKILESRRRSDWILPPKARYTPEKQMRTKPSFKSIKINELVGNKRIRSILSRFEGGVAGIRKRDWDSTQ
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MACSLVTGMKNECRPIQVNNVMYRYYPKTYKAYPNSVDWIPKYQRENFNHSSTQRHDYKPYGNAKPDTFIRRAALARNNGLNKQQIFFHHGKKYNDNMISYYDQVYNKRDLEHIPTNRRWDLKRIAWLPEKSDVPIYGNATKFGLLEKKKEQWKKEVEEENRGIYSSETMTSFAELPKNSLITKHQVTPKHISSRMHPHHLNKDLALRSLPIINPVPQIDSYKFTLYRQFGKVYHE
The following text describes a protein:
Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MNDETNKNNSNINNNNNNNNSSALVLVDNVRYDKAIIRPLPTKAYYGLEYPANVQNADKAIESVGGLSKISNVIKSREKEYLQLKFRPNNPTCKPTFGTKSPTCHLLLRVRPNKQQTQTQTQTQTQDNNEEMNSPKPTIQSPKTTSRSKQQQQQQQPQENEKFDATIIALVPSTIRFDGLCDFQYLIKSDNNNTKSESDNVNDSSSSSSSKTVPITKQKDQYYVQQYSDNNEIMKDEPMNLIPPLFSRIDFPQNYLFKANPNAQFDKTSKQFVFAKQTTRKATGHAKFNNVIPVAPQELPKVFGVNELMKKTRDILVALFEKRPIWLYISLLDKVQKEGGLVAHTKRVLPSLAFNFVDGPWRKCWVKLGFDPRIHPETSQYQTIDFRISEQDNHYPSNQPSKNNNNNNNNKDSIKNKEKDNSNKEDKEHKEDKEDKQEEDKENNETDNNEKSNKIDEESRDNTKNTDGGEDKNNKNIVEKKNNNEKGDDNNIDDGDEIMKNKEDENGEGNNNNNNNNNNKEGVSEVQKLGRGHKDEKLIIQNGVSGETKINPSRKKLLDINTFEFNSQLPTSSSSLSSSSTQPLLLLKGGSGDDAQDFYQAPVYDYTFKTAPSMLSNLYQIIDIEEPSIAEYWASVKIQSTCQKKFGWFSESSFREGLERMKARFGVMDNKMRFKSRSNTSTATTTSTKSTQPKSTQPKEPKLKSTQPKEPRPKGRPRKYAIKKDKNNNNNVDNNNDDSIDKMDLDDEETTTKSNKQNKEIDESLKNDTLAQMEKDNEYLHGKNEEIEIEIDGGVVGGFDYDDDDDDEDKPFELLDDFDGTDNIQMKQIDDFFGTQTNEDSEEDESDFDEEEEEEEEDFEFEESE
The following text describes a protein:
Function:
Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
Sequence:
MYETEEDPTTSNVATTNNEKTASTAATTTEPVKKVTEFMRVQRLFRQVTKSANGKNIPKEKREPIDYSPVLDFHNLENNTEENKKLIIDCTSNVTTHDFEFNRDTEFYLHPREWKVYGLQGYPGFYFIKSPFTASQQKKWIKHALEDYADPPNNNNITLFHGPIKNLWKNGEKELINEELKSQGKHDDDEIEQPTRPLDKNGEPLPTYRQLLDKLAWSTLGYQYQWTPRLYSEEFYEEFPDDLQELVQKIAIATKFDPYVAEAATVNFYSEDSIMGGHLDDAEQEMEKPIISISFGSTAVFLMGAETRDIAPVPLFIRSGDIVIMGGRSRYCYHGVAKIVENSFDLGLIDENDDQDLKYKIQWLKEKNRRVNINTRQVFKVPKLGGKLINKNE
The following text describes a protein:
Function:
Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle (Probable). Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome. Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes. Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication) (Probable). Activates preferentially the methylated forms of the viral lytic R (BRLF1) and Na (BRRF1) gene promoters, the latters being the first genes activated during Z-mediated reactivation in latently infected cells. BZLF1 and BRLF1 act together to trigger lytic replication. Also binds the lytic origin of replication, oriLyt. Induces G1 cell cycle arrest by stabilizing the host CCAAT/enhancer binding protein CEBPA. This function is important because the lytic cycle preferentially takes place in host cells arrested in G1.
Subcellular Localization:
Host nucleus.
Domain:
Recognizes the CpG methylation marks through a specific serine and a methylcytosine-arginine-guanine triad. The leucine zipper region contributes to homodimerization. The basic motif is involved in specific DNA-binding.
Sequence:
MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAPQPGDNSTVQTAAAVVFACPGANQGQQLADIGVPQPAPVAAPARRTRKPQQPESLEECDSELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLNF
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Subcellular Localization:
Cytoplasm. Late endosome membrane; Peripheral membrane protein.
Sequence:
MENTSTPITGLAWISSVTLCPRTYNMIVATVEGASANFLKGFNQKSAVYLGYSTALEGLEQVITDIQILNEKTVLPVGYAFIGEHLDPKISVPKKKRLCVKQMPMHTAETAVCEIKFSMKSKHIGAPFERIGEISGLVFWCRKGSVPSPKPTPKPRNITSGIKGLSLDINTPVQPVRRASAPVPDAGQVVPQSNGKWPLSENAIYDSSNIYGISAIDGIPFTIHPMFENTVNNTSVVTSDFRDLHIKTLSEIESEYNYGFVVERTAAARVPPPLR
The following text describes a protein:
Function:
Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Mitochondrion matrix. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Retention in the cytoplasm contributes to its inactivation. Translocates to the nucleus upon oxidative stress and in the absence of survival factors. Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress. Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity).
Sequence:
MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG
The following text describes a protein:
Function:
Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Plays a role in maintenance of retinal lens optical clarity (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed primarily at the plasma membrane in peripheral lens fiber cells, however also localizes to the cytoplasm in mature lens fiber cells.
Sequence:
MSTRRVVVDAPAGASSSMPLQRHKASFRAAQSPSSLDGLPASRTVAVSGLVRTPRVYVGMAPSGPTGGLGARVTRRALGISSVFLQGLRSSGLATAPAPSLERDLGAVEDLGGCLVEYMAKVHALEKVSQELEAQLRMHLESKATRSENWGALRASWASSCQQVGEAVLENARLMLQTENIQAGADDFKERYENEQPFRKAAEEEINSLYKVIDEANSSKMDLESQIESLKEELGFLSRSYEEDVKMLYKQLAGSELEQLNVPIGTGLDDILETIRIHWERDVEKNRLQAGALLQAKQQAELARRAQTQEEKLAAALRVELHNTSCQIQSLQAETESLRALKRGLENTLHDAKHWHDIELQNLGAVVSRLEAELREMRAEAEQQLQAREHLLSHKCQLQRDVASYHALLDREESS
The following text describes a protein:
Function:
May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNTNKLSLRRNVIYLAVVQGSNYLLPLLTFPYLVRTLGPENFGIFGFCQATMLYMIMFVEYGFNLTATQSIAKAADSKDKVTSIFWAVIFSKIVLIVITLIFLTSMTLLVPEYNKHAVIIWSFVPALVGNLIYPIWLFQGKEKMKWLTLSSILSRLAIIPLTFIFVNTKSDIAIAGFIQSSANLVAGIIALAIVVHEGWIGKVTLSLHNVRRSLADGFHVFISTSAISLYSTGIVIILGFISGPTSVGNFNAANTIRNALQGLLNPITQAIYPRISSTLVLNRVKGVILIKKSLTCLSLIGGAFSLILLLGASILVKISIGPGYDNAVIVLMIISPLPFLISLSNVYGIQVMLTHNYKKEFSKILIAAGLLSLLLIFPLTTLFKEIGAAITLLATECLVTSLMLMFVRNNKLLVC
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSAKSSEPPFEPSSEGEQLPSRFEVELEFVQSLANIPYVTFLLTQHQIWQDPRFKAYLKYLEYWCEPPYTQFIVYPNCLFVLKLLNSFLDKAVENEDGILEGAEDLPKVIQMQGGEWMNQMVERWRG
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MAERKVRVRFAPSPTGALHIGGVRTALYNYLFARQHGGDLIFRIEDTDSNRFVPGAEEYILESFKWLGIHFDEGVSFGGEHGPYRQSERREIYKKYVQILLDNDKAYIAFDTPEELDAKRAEIANFQYDASTRGMMRNSLTMSKEEVDALIAEGKQYVVRFKIEPNEDVHVNDLIRGEVVINSSILDDKVLYKSADELPTYHLANIVDDHLMEVSHVIRGEEWLPSAPLHVLLYRAFGWEDTMPEFAHLPLLLKPEGNGKLSKRDGDRLGFPVFPLEWRPESGEVSSGYRESGYLPEAVINFLALLGWNPGNDQEVMSMDEMIKLFDIHRCSKSGAKFDYKKGIWFNHQYIQLKPNEEIAELFLPVLKEHGVEAPFEKVVTVVGMMKDRVSFIKELWDVCSFFFVAPAEYDEKTVKKRWKEDSAKCMTELAEVIAGIEDFSIEGQEKVVMDWIAEKGYHTGNIMNAFRLTLVGEGKGPHMFDISWVLGKEETLARMKRAVEVLK