lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes. Required also for cell cycle progression. Positively controls G1 and the timing of START.
Miscellaneous:
MISCELLANEOUS: Present with 639 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTISTLSNETTKSGSCSGQGKNGGKDFTYGKKCFTKEEWKEQVAKYSAMGELYANKTIHYPLKIQPNSSGGSQDEGFATIQTTPIEPTLPRLLLNYFVSMAYEDSSIRMAKELGFIRNNKDIAVFNDLYKIKERFHIKHLIKLGRINEAMEEINSIFGLEVLEETFNATGSYTGRTDRQQQQQQQQFDIDGDLHFKLLLLNLIEMIRSHHQQENITKDSNDFILNLIQYSQNKLAIKASSSVKKMQELELAMTLLLFPLSDSADSGSIKLPKSLQNLYSISLRSKIADLVNEKLLKFIHPRIQFEISNNNSKFPDLLNSDKKIITQNFTVYNNNLVNGSNGTKITHISSDQPINEKMSSNEVTAAANSVWLNQRDGNVGTGSAATTFHNLENKNYWNQTSELLSSSNGKEKGLEFNNYYSSEFPYEPRLTQIMKLWCWCENQLHHNQIGVPRVEN
The following text describes a protein:
Function:
Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MITVTPGELATIDDALTDLLLERVFYWAEVRKASVHYKPLRGISDRHIHDLVRSIAACETGAAANLAVKKATNAFLELKEVRGYRGRLSPLAYEEFQRHTVRYLTIYKASCGFEINVSMRYKCRSNRGESCVISRVRYNRGDEIVGLSGCLAKMTKDEELALANDFSVLHSSRRGGNCLMLGPARFVNHDCSANARFVPVPSGMVIQAVKPINVGDEITVKYAENYFGRRNKECLCQTCEENSRGLYGSPQESSEEESDDDMDELTKIELQRRKKRQEQREGGTPELREGGRGSSESSRETSEEAIEISTSKNWPLIPKIESHTADSTPLPVPVGEVSEATVTEVSTVVPAQEAIPVNESTTALSQSSNEFQDPTIDPILNGASAEIRFPSLPSPDTTTSPESQVPPFIQPKSARRNHHYLGMHNTDERVRFNDRLSVLDERGGSEDMESCLVSGSESRDDSTAMSRDEESSRDDGDGSRSKRSKRHVRAQRKNSGSWSFSQEDLSFDRLCKAAREQAYDPSRYALTGVYGFSVSGATQTCVSCCSVYNLTDGPKTLGHFCPRCHRHAAIHSFAWPYTNHKHALPLCLLMMRPPKKLEDEDWGLSKPQVAQQFGAKNRKIFEEDGSLVQKKRKSLAWSWEYTKEEPAQEITSMRIEDMSPKELKKWSQAGRQTRSGRVSMLPEKPKRSRKSAPEPVEMRDNVAQLSREERAWKRARRGTVGHEKVEVNTPTVETPSTGTPKVKKLHWKQKLAMERRQKEAEAAEVAETRVADGVDASTPSPAGSTPTPRGRGRPRKSSREEEIPPEKTPEAKRPSPAATKTPSMSPKVKKEPLSMSFSMSPTSRSGRVRNPTEKALQLMEQGEYVI
The following text describes a protein:
Function:
Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYAYWPQPDGRVLGFIDVPGHEKFLSNMLAGVGGIDHALLVVACDDGVMAQTREHLQILQLTGNLQLTVALTKADRVDEARIGEVREEVLAALDNYGFADTVLFVTAANEGRGIAELRAHLQQLPARSHAAQHRFRLAIDRAFTVKGAGLVVTGTALSGEVNVGDTLWLTGVNTPMRVRSLHAQNQPTDHAYAGQRIALNIAGDAEKEQLNRGDWLLSDAPVGEAFSRVIVSLALHAPLSQWQPLHIHHAASHVTGRVSLLEGGLAELIFDTPLWLADNDRLVLRDISARATLAGARVVTLKAPRRGKRKPDYLHWLSTLAAAQDDSAALAIHLERGAVNLPDFGWARQLNPLGMRQLIEQHGFIQAGDNLLSAPVAARWQRKILDTLATYHEQHRDEPGPGRERLRRMALPMEDEALVLMLIERMRDDGLIHSHHGWLHLPDHKAGFSDEQQAVWQKVEPLFGDEPWWVRDLAKETGTEEQLMRLVLRQAAQQGIITAIVKDRYYRNDRIVAFANMIRELDQERGSTCAADFRDRLNVGRKLAIQILEYFDRIGFTRRRGNDHLLRDALLFPQKE
The following text describes a protein:
Function:
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Sequence:
MKSIEVKGTARTIAERSSEQARALKEIRKNGGVPCVLYGAGEVVHFTVTNEGLRNLVYTPHIYVVDLDIDGKKVNAILKDIQFHPVKDNILHVDFYQIDEAKPIVMEVPVQLEGLAEGVKAGGKLALQMRKIKVKALYNVIPEKLTVNVSHLGLGKTVKVGELSFEGLELISAKEAVVCAVKLTRAARGAAAAAGK
The following text describes a protein:
Function:
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region. Note=More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis (By similarity). Localizes at P-bodies during gonocyte development.
Domain:
The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Sequence:
MDLPPFDMWRDYFNLSQVVMDIIQSRKQRQEGEVAEEPNSRPQEKSEQDLEGYPGCLPTICNFCKHNGESRHVYTSHQLKTPEGVVVCPILRHYVCPLCGATGDQAHTLKYCPLNSSQQSLYRRSGRNSAGRRVKR
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MALFHVARYAGPEAAGAEAEADGRARALLERLQCRARERQLQKQPPQQAPEEAAQSAPAAGKRRRRPRRTRRREGGREPGSPPAPPNKRQKTDDEDENEDEGAESSEETPAESSVGAEAAGSPEGRGGPPPEEASGPLTHALVLGGFGRSKVPKVQPFLPVWLAQPSCVGKNVTEGLVPIEDIPEVHPDLQKKLRAQGISSYFPVQAAVIPAVLESTANGFLVSRGGYRPSDLCVSAPTGSGKTLAFVIPVVQALLHRAVCQVRALVVLPTKELAQQVSKVFNVYTDATPLRVALITGQKSLAKEQESLVQKTADGFRCLADIMVATPGRLVDHIDQTPGFSLQHLRFLIIDEADRMIDSMHQSWLPRVVAAAFPSEGPRDPCAVFQRTQPRVLTAASMCCPQMPLQKLLFSATLTQNPEKLQQLGLYQPRLFSTGSAHRGPSDPDIDVDEDSGGKYTFPTGLKHHYVPCSLRFKPLVILHLILEMNFSRVLCFTNSRENSHRLFLLVQAFGGVTVAEFSSRYGPGQRKSILKQFEQGKIQLLISTDAMARGIDVQGVQLVVNYDAPQYLRTYVHRVGRTARAGKSGQAFTLLLKVQERRFLRMLEEGGVPGLERHDTPSELLQPLVPQYEEALSLLEKAVKEERKQKAA
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVRRLRWREGGPMTNPNAHTLPIIVVGAGMTGLAAAWELQQRGVPYVLLEAGDSFGGKVQSERTEDEFLVEKAADAFILGKPWALQLAQEVGLQDELIHPRAETKKLYFLRGGELLDFPQNLKMFVPLDDESFLQSGVLSPEGLRRMLDEQNVPPKENTDEDESLADFIIRRFGAEAMNFIVPLAAGIYVANPFELSMKAAFPQFLALEQKYGSVIKGSRATPRAQGPIFGSFKDGMSTLANAVAAKLTGDVRLNTPVLAVHPDGVTLTGGEKIAASGVVLTAPAWVAAPTLGQSFPAASALVGELQTNGSVAVILAYREGQFPRDMHLHGLQVAADEGIEMKAITVHSAKLHGRAPEGHVLLRVFFKDLDPQKALAEAVHEVARLFGAQGDPLWHAYADWRGKNPAYQVGHLDHIARIRAALPPNIQVAGSSYTGVGIPDCVNAGRTAARDVVAALGVDG
The following text describes a protein:
Function:
Required for bacteriophage N4 adsorption. May be a component of the phage receptor.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDWLLDVFATWLYGLKVIAITLAVIMFISGLDDFFIDVVYWVRRIKRKLSVYRRYPRMSYRELYKPDEKPLAIMVPAWNETGVIGNMAELAATTLDYENYHIFVGTYPNDPDTQRDVDEVCARFPNVHKVVCARPGPTSKADCLNNVLDAITQFERSANFAFAGFILHDAEDVISPMELRLFNYLVERKDLIQIPVYPFEREWTHFTSMTYIDEFSELHGKDVPVREALAGQVPSAGVGTCFSRRAVTALLADGDGIAFDVQSLTEDYDIGFRLKEKGMTEIFVRFPVVDEAKEREQRKFLQHARTSNMICVREYFPDTFSTAVRQKSRWIIGIVFQGFKTHKWTSSLTLNYFLWRDRKGAISNFVSFLAMLVMIQLLLLLAYESLWPDAWHFLSIFSGSAWLMTLLWLNFGLMVNRIVQRVIFVTGYYGLTQGLLSVLRLFWGNLINFMANWRALKQVLQHGDPRRVAWDKTTHDFPSVTGDTRSLRPLGQILLENQVITEEQLDTALRNRVEGLRLGGSMLMQGLISAEQLAQALAEQNGVAWESIDAWQIPSSLIAEMPASVALHYAVLPLRLENDELIVGSEDGIDPVSLAALTRKVGRKVRYVIVLRGQIVTGLRHWYARRRGHDPRAMLYNAVQHQWLTEQQAGEIWRQYVPHQFLFAEILTTLGHINRSAINVLLLRHERSSLPLGKFLVTEGVISQETLDRVLTIQRELQVSMQSLLLKAGLNTEQVAQLESENEGE
The following text describes a protein:
Function:
Involved in the formation of X-, Y-shaped and twinned plasmodesmata (PD), thus modelating PD size exclusion limit and regulating cell-to-cell transport. Cell cycle checkpoint regulator that monitors and responds to DNA damage such as DNA cross-links, and triggers the halt of the cell cycle progression in the presence of DNA cross-linking agents. Mediates the active process of aluminum- (Al) dependent root growth inhibition and thus is required for response to Al toxicity. Required for both early and late phases of embryo development as well as during seedling growth. Essential for signal transduction and development of both male and female organs.
Miscellaneous:
MISCELLANEOUS: 'Tanmei' means short life in Japanese.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus in response to DNA damage mediated by treatment with AlCl(3), mitomycin C (MMC), or cisplatin (CDDP).
Sequence:
MSKRPPPDPVAVLRGHRHSVMDVSFHPSKSLLFTGSADGELRIWDTIQHRAVSSAWAHSRANGVLAVAASPWLGEDKIISQGRDGTVKCWDIEDGGLSRDPLLILETCAYHFCKFSLVKKPKNSLQEAESHSRGCDEQDGGDTCNVQIADDSERSEEDSGLLQDKDHAEGTTFVAVVGEQPTEVEIWDLNTGDKIIQLPQSSPDESPNASTKGRGMCMAVQLFCPPESQGFLHVLAGYEDGSILLWDIRNAKIPLTSVKFHSEPVLSLSVASSCDGGISGGADDKIVMYNLNHSTGSCTIRKEITLERPGVSGTSIRVDGKIAATAGWDHRIRVYNYRKGNALAILKYHRATCNAVSYSPDCELMASASEDATVALWKLYPPHKSL
The following text describes a protein:
Function:
Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.
Sequence:
MSQQDAVAALSERLLVAAYKGQTENVVQLINKGAKVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPAAGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN
The following text describes a protein:
Function:
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Subcellular Localization:
Cell membrane. Synapse.
Sequence:
MEMMGVERQCEVAVQKQSQRELQWVQKQLSIISNRTNGPSRSKDKKLKNEVFPLHLSGFPAQHVEAYRLLEDRKHKLSPETAALCLLRQQHTLLETEISRKRKECEVLEEEVKKKSQSCQTLESELQHVLQEKARLNLRLFNDNQKAAKYEQVKSEYEQLQEALYTVTVERDCALLERTELQGKLENLEQVLKHMREAAERRQQLELEHEQALAVLSAKQQEIDLLQKAQVEAKKEHEGAVHLLENHLDSMQLRSVLRTKNTMRFLAKVRELEEKCRTQSEQFNLLSKELEKFRLQAGKLDILSSSQLTGGDSPGSPTKPLTLSQLLNGLTAPSGKGNEDSMSKISELIRPLQMTEGEKVELLSVKPSFLSRSTPSSPRRAFLSEVRPVIATAMDKELGSSPRSKSRYTGKVRLCVARYNYNPYDGPNEHPEAELPLVAGKYLYVYGTMDEDGFYEGELLDGQQGLVPSNFVDFVQDEELPSAPLLDRIKEPSYLNHSPASMPSSAVSTLSTLLSEKLDALGSGTGTGTSSSSGVSSLGMSTGLGIDYLGPCSNGTGTLDVNIDEIGEDIVPYPRRITLIKQLAKSVIISWDPPVVLPGWTPISGYNVLVDQEVRMSIPFGGRTKSLIEKLNLTVCTHRISIQSMTERGLSDPLRCTLLVGKDVVVAPYYLRVENITQASAELTWMPSNSNYSHMIYLNDVEYDVVKPGGYKYHFYNLKPMTVYKIRVVARPHQMPWQLPLEQREKKEVSVEFCTQPAARHAFLQKPEVGTSRLNCSSGPPLPPQDVQVQLGQTPGVLQIRWKPPTLTPNGTSNGASVMGYIVFTKGQKIAEIMHPTADFVTVELNRIQCLEAREVIVRTISAQGESQDSPVATIPHSLLVPHPHGHLHLQSHPQTHPPPYPQAYPPTHPQPHVQPHSMPPSHPHPQPHIHPPHSSYPMSKPKLLPSARDPHAKESEMGRRMGQPWEPHPRAPSPLPHHSHHGHTLEPPHVEGRRSPSPQRILPQPQGVPIPNTVARAMARQAAQRNAPNSRVERRNIFSDRGNALHSLNSDEEEEGYDSPHARRKGASVDEFLRGSELGRHHHHYSHSDEYYTESSRGSDLSDIMEEDEEELYSEMQLEEGRRRSINSHNTLKAYYRRQDLAVERDSWDLQREVVRQRSLRSHKRLHSIPEVAEEDPDTGVEVMGQRLRFEEARPGTPCRSPRPYHQDSRQSNHLSPSKCVRRLQRQRSSPRYTSIEERPPCWSSSSSRQTTKSPDSGLDCGSEEEGSLGYRGGYHSYMGGSPLRVGSGPNMRLIHSEGPVERRALAAGRKRTLTRQCSVEEDFLDAIPETRSMRESYHHYHYHPHHHHPQRRFRSEGRLSEVGRTYHRDIRAYSVARLNRAMDEPLILGSSPSTGRSDRLDHSGRRTGHGCPPAQRRPMTVPSIEITMENNSEGSEGNLSPIKDDVYYTNVAHRRKWPAQRTEHRYDGYGRERRSPDYYESEPEDLSRIFVAMFDYDPLSMSPNPDAAVEELPFKEGQIIKVFGEKDTDGFYRAEICGRRGLVPCNMVSEIQTDDDEMMDQLLKQGFLPLNTPIEKIVNCNRFKDGRSVNRRSRKSKRERNKRSGRQHAVSTRRMVALYDYDPRESSPNVDVEARYGGSLQSEEAELTFCAGDVITVFGEIDEDGFYYGELNGHKGLVPSNFLEEVPDDVEVYLTNTPSRHPQDHPSRTKNKRKKSVHFTP
The following text describes a protein:
Function:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Sequence:
MTQDCVQSSLSAHPDRFRGNPRFANLASWLTVDPPMDLVPKSPTSFMNKLMPGCIPKINTSGGQFKMMENITNFQNAAKQWGVPEIDVFQTVDLWEKRNIAQVAQCLMAIGRACYNHPEYTGPCLGPKPSEEQKREWTQEQLRASEGIINLQYGSNKGATQSGQNFGNTRHM
The following text describes a protein:
Function:
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
Sequence:
MIANENIQDKALENFKANQTEVTVFFLNGFQMKGVIEEYDKYVVSLNSQGKQHLIYKHAISTYTVETEGQASTESEE
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MPREPWQRAHGHGGLGPRHRSTSGLRRGLFRPRDGEEDGGENHRDDRVRGGRLGHTAGSQFPSDMEGRVHGGYPSRRYYVPAAGDSCVRGSYPASTRYLTVGDSSRPSMASRAREEADSLERELHSIERSIVIPMCLNPEAREFFPDRDRGTAQRLDRYLAAAKRLQRLDTSGDIDQRKKSLLKTVMSCLADEFCHLKVWRLDDATARDHSPASIWDSVRRSRSGSQDSRMSSSSSLSFTGSGGTSDASYGSYHRGFGEEPSVQSHSTFAAGMIYVDRRSLSILGDIASVMIGSGYEYILRAAFDRHCAQLARYIEILDIDNIFGYQMGESRQILLRVWTSAVHIIISFLMEMQRQLDAHDFGSFDKIKQEYFLAIAKVTVMKLLDSANSISFQVDPPTDQSCKNSYGAAKRNLSKMVDVVMVYQALDHGLPTILSLLSGKTKELVVAEGEELIKRLSDVFAKLSDELNNTVRSQYLFITDTGVHRFTKHVMDHIRLLVQHKRIIYPMLEGGLESFGELVTRLIWSLEFMLNVNSRSLQLQGQEQIFLLNNVQFMLEAAEKNTELVLILGESWFLRCHDQIDQFIAGYVDVCWTPVMSSLERKTRFSLILWPHQLLCKFTLAFEVTCSAHKNWKVADPLMRHKLREAISHKVLPSLYRMHAVECDSEKMNKSARYSIEQVESQLLELFEG
The following text describes a protein:
Function:
Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin.
Subcellular Localization:
Fimbrium. Note=Part of the curli surface structure.
Sequence:
MKLLKVAAFAAIVVSGSALAGVVPQWGGGGNHNGGGNSSGPDSTLSIYQYGSANAALALQSDARKSETTITQSGYGNGADVGQGADNSTIELTQNGFRNNATIDQWNAKNSDITVGQYGGNNAALVNQTASDSSVMVRQVGFGNNATANQY
The following text describes a protein:
Function:
Involved, with RAD23 in spindle pole body duplication. Involved in the ubiquitin-proteasome proteolytic pathway.
Miscellaneous:
MISCELLANEOUS: Present with 3930 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSLNIHIKSGQDKWEVNVAPESTVLQFKEAINKANGIPVANQRLIYSGKILKDDQTVESYHIQDGHSVHLVKSQPKPQTASAAGANNATATGAAAGTGATPNMSSGQSAGFNPLADLTSARYAGYLNMPSADMFGPDGGALNNDSNNQDELLRMMENPIFQSQMNEMLSNPQMLDFMIQSNPQLQAMGPQARQMLQSPMFRQMLTNPDMIRQSMQFARMMDPNAGMGSAGGAASAFPAPGGDAPEEGSNTNTTSSSNTGNNAGTNAGTNAGANTAANPFASLLNPALNPFANAGNAASTGMPAFDPALLASMFQPPVQASQAEDTRPPEERYEHQLRQLNDMGFFDFDRNVAALRRSGGSVQGALDSLLNGDV
The following text describes a protein:
Function:
May be involved in the exo-endocytic cycle of synaptic vesicles.
Miscellaneous:
MISCELLANEOUS: The name 'target of wit' comes from the observation that expression of this protein in certain regions of the central nervous system is dependent on the BMP signaling-pathway activated by the receptor protein serine/threonine kinase wit/wishful thinking.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Presynaptic cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Sequence:
MSAVPMKAFLAGLFLLANAWHITAINEQHQKHHLQCWHCSSDTIGAEDFCDVTFQEDNIPTDLIKERNINLLRSCNGTINSDHERAVCRKTVEENNGKLITKRFCYYTNKSDPVELCNITSPEKNVRRIFCEDCLTDRCNGALAGASILEMLLLLPIAGLIQQFAI
The following text describes a protein:
Function:
Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.
Subcellular Localization:
Nucleus.
Sequence:
MATSPAEPSAGPAARGEAAAATEEQEEEARQLLQTLQAAEGEAAAAGAGDAAAAADSGSPSGPGSPRETVTEVPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRSPEDLERGVASMAAEAPAQSSIFLAGATSPATCPASSSILVNGSFLAASSPPAVLLNGSPVIINSLALGENSSLGPLLLTGGSAPQPQPSLQGVSEAKNSLVLDPQTGEVRLDEAQSEAPETKGVHGTTGEEIPGALPQVVPGPPPASTFPLTPGAVPAVAAPQVVPLSPSSGYPTGLSPTSPRLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPTNVHLINSSVGVTALQLPSSTAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPISTQPLPPASVVTSGTSLPFSPDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDPQGLLLGATTGTEVDEGLEAEAKVLTQLQSVPVEEPLEL
The following text describes a protein:
Function:
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
Sequence:
MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVDFPVILYEV
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSILKLLPQSFVSSLQKSSWVEYRKMGLYFADLYNNTEANQEVYRRLPFDVLVQRDRRLRVAIDLSLKKQLLPESEWSDNQKDFEFTEMIEKYTEQVERENDLRRSFRE
The following text describes a protein:
Function:
Neuropeptide-like protein. Plays a role in behaviors associated with a sleep-like state induced by stress (SIS), acting in concert with the FARP (FMRFamide related) peptides, flp-13 and flp-24.
Subcellular Localization:
Secreted.
Sequence:
MSQKLLPISPLQLLFLQCLLIGFTAAYPYLIFPASPSSGDSRRLVKRAFDRFDNSGVFSFGAKRFDRYDDETAYGYGFDNHIFKRSADPYRFMSVPTKKAFDRMDNSDFFGAKRKRSFDRMGGTEFGLMKRSAPESREQLINNLAESIITLRRAREAESSPESQRTIITYDD
The following text describes a protein:
Function:
Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major oxygen-insensitive nitroreductase in E.coli.
Sequence:
MTPTIELICGHRSIRHFTDEPISEAQREAIINSARATSSSSFLQCSSIIRITDKALREELVTLTGGQKHVAQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMAQNALIAAESLGLGGVYIGGLRNNIEAVTKLLKLPQHVLPLFGLCLGWPADNPDLKPRLPASILVHENSYQPLDKGALAQYDEQLAEYYLTRGSNNRRDTWSDHIRRTIIKESRPFILDYLHKQGWATR
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. The DASH complex mediates bipolar kinetochore-microtubule attachments and facilitates the formation of additional interactions between outer kinetochore components and spindle microtubules. During chromosome movement along the microtubule, it is required both for the sliding of kinetochores along the lateral side of the microtubule and also for microtubule end-on pulling on the kinetochore. Modulates cytoplasmic microtubule dynamics by tracking the plus-end of shortening microtubules and slowing their depolymerization. Plays a role in meiosis.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Note=Associates with the mitotic spindle and the kinetochore. Kinetochore association occurs only during mitosis. Localizes to cortical microtubules. During metaphase, localizes to the plus-ends of intranuclear microtubules (INMs). Does not localize to cytoplasmic microtubules.
Sequence:
MNNLEQLERLEQSITLALYEIDANFSKCHRTVTTKILPIVEKYAKNCNTIWDSSKFWKQFFEASANVSLSGVEEPVPVESNPSDQDVMSNSTEADLQLHTKNEHLEKRHSFVGKSDFPDAAVQGDNTKNEDFVQSTPKKMDVSLEDISLDDAALTPIPARMQTPLRKPENNPHTGRSALLHRVLDTNWQVQVTPREPKNLQSQEVMDIDSSPFVSPSPISMKMDMPSLNDRNSSHALSLFAEFEHESYDSINPSGMSPPKTIQFSPHTMGVGSSQQANERSLSLQRKLETLNDSNDSFVKEEDSWEL
The following text describes a protein:
Function:
Specifically methylates the N7 position of a guanine in 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MIDAEFKTALEQFGLELDEPLGMSLQQYAQSLWRYNEQINLTRHTTWDLFVTRDLRDCLQLAQLIQPGEEVLDMGSGNGVPGIPLAMLRPDIDVALAESVGKRAKVLDELVTELNLPVPVYAARGEDLLEDFRFTTIVSRAVGSLLKFCRWVEPHWSQFDRLLLIKGPKWVDERGEARHHGVLKGLELRVVATYPLGSVAPELAEAEEGDSPEAADASRGVILELTKKNKG
The following text describes a protein:
Function:
Required for proper chromosome segregation during mitosis and error-free mitotic progression.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MSEGQQIKENTQQNEILIGMPKSGNPWKKLSTKSSTRTKRFHKVSWEEKQKQRQQKKELQDYLKEYKAEKEKQIQEEKLRKKNKKKQDELNKYKTADLQIIKESKNIKKWTKKARKTLVKLPAEIFETLLEKQRRR
The following text describes a protein:
Function:
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.
Sequence:
MEQPKGVDWTVIILTCQYKDSVEVFQKELEIRQKREQIPASTLLLAVEDPEVHVGSGGATLNALLVAAEHLSARAGFTVVTSDVLHSAWILILHMGRDFPFDDCGRAFTCLPVENPQAPVEAVVCNLDCLLDIMSHRLGPGSPPGVWVCSTDMLLSVPPNPGINWDGFRGARVIALPGSTAYARNHGVYLTDSQGFVLDIYYQGTEAEIQRCARPDGQVPLVSGIVFFSVETAEHLLATHVSPPLDACTYMGLDSGAQPVQLSLFFDILLCMARNVRREDFLVGRPPEMGRGDMETEGYLRGARAELWRELRDQPLTLAYVPDGSYNYMTNSASEFLHSLTFPGASGAQVVHSQVEEQQLLGAGSSVVSCLLEGPVQLGPGSVLQHCHLRGPIHIGTGCFVSGLDAAQSEALHSLELHDLVLQGHHLQLHGAPSRAFTLVGRLDSWERQGAGTYLNMSWSKFFQKTGIRDWDLWDPDTPPTERCLLSARLFPVLHPLRALGPQDMLWMLDPQEDGGKALRAWRDSWRLSWEQLQPCLDRAATLASRRDLFFRQALHKARHVLEARQDLSLRPLIRAAVREGCPGPLMATLDQVAAGAGDPGVAARALACVADILGCMAEGRGGLRSGPAANPEWVRPFSYLECGDLAGGVEALAQEREKWLSRPALLVRAARHYEGAGQILIRQAVMSAQHFVSTEPVELPAPGQWVVAECPARVDFSGGWSDTPPLAYEHGGAVLGLAVRVDGRRPIGARARRIPEPELWLAVGPQHDKMAMKIVCRSLDDLQDYCQPHAPGALLKAAFICAGILSVHSELSLSEQLLCTFGGGFELQTWSELPHGSGLGTSSILAGAALAALQRVAGRAVGTEALIHAVLHLEQVLTTGGGWQDQVGGLMPGIKVGRSRAQLPLKVEVEEITVPAGFVQKLNDHLLLVYTGKTRLARNLLQDVLRSWYARLPPVVQNAHNLVQQTEECAEAFRQGSLPRLGQCLTSYWEQKKLMAPGCEPLAVRHMMDALAPHVHGQSLAGAGGGGFLYLLTKEPRQKEALEAVLAKTESLFSGQAKGAPHTRSRLRMVAIWESRANLSRMVQVVTVVRLRMNCCTQGSLAS