lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Regulates oocyte maturation. Enhances androgen receptor (AR)-mediated transcription in a SRC-dependent manner.
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The Glu-rich region mediates histones interaction; The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.
Sequence:
MEVTIAGILERDLSEGELAEAIRGLREHGAFRGEGLPAAMSGLLSSCNSRLTSASSRIEGLSLLALAVEESPTDVFVQHCVSWLRSLLQIIQSQDPPRVVSLAVFVLRSLLAHSSALPELSREISTNHIPGLLTSLLGLRRQCLVPALEGIRSCFLSYPRACGSLRGKLTAFLLSLLDAENQQIQEVACQCYSLLPSLGSGFSQGIKHTENWERQIQSVICSLHSVFLQLYQGSETDTARYEGSGTELEFPSVEDDGTHGVLQLARRFTALGQCMRLLLREQFPAPVRVPVSDILSLVCRVVNVSPKNLSWHGEESLKLLLLPRVHSSILEILEATIIACGPRLLPFSAVICRLFPQLLLSWAAVKGITGIPSGQERPYSSLRCSVYRVLETWVTTCGISSGVLQGPMHHSDILLANLLSDITPPTDAIKMSTFVQLGAKKQKVSEVGDDDFQSHRKRDNTANVELCAAALKGLCCVILHCGSVIKEDVHRRLQELSIPLLLRLQQGSDQWLGPYISSDCRKELYRLLLCLTLTPNPKLPAPLHCAIRIFRGGTTEESLQVSRFSTEALAICRILIHPRVPSLQRPLPHLAPRPSVQSDAPTLRPPAALSTFPAMPPANHLPPRPTVPAMSTEPPIPAAVPSPPPEESFGEKPRRAVFIHFDKEEPSDVEISLESDSDDSVVIVPEGLFAKSDSKPEPSPPAVKPPTEEVTEQVAPSAVPSSSTAAPPPPPPPPAPPVCAGPSSAPVPIAEAPPPPQQEVDTVININSSDDEEDGEEDEEEGLYDDEDEEDYYDEEEDEDLEGLEEDDYDYEEDEEGITEEEEEDLEEEGEDDEEEVEDEECLMPDEMQIGSEAEEIPDGIETSSLHEGELEEGPPRLSPVQEDEAVDTGLLMLVESEDREPSGEAPGEGLPESDLTRSPPQPPVLTPPSPPDEPPPMEESDVPPLEEPDLEVAPVAEEPVEETEEKKPEEVTVEKPEPEPEEEEQIADADAMLADFVDCPPDDDKLPEPCT
The following text describes a protein:
Function:
Glycosyl-1-phosphate transferase that mediates the first step in the biosynthesis of the undecaprenyl-linked heptasaccharide donor in the N-linked protein glycosylation pathway. Catalyzes the linking of uridine 5'-diphosphobacillosamine (UDP-Bac) to undecaprenyl phosphate to create the first membrane-associated intermediate undecaprenylpyrophosphate-linked Bac (Und-PP-Bac).
Miscellaneous:
MISCELLANEOUS: N-linked protein glycosylation in C.jejuni consists in the transfer of a heptasaccharide (GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-bacillosamine) from a membrane-anchored undecaprenylpyrophosphate (Und-PP)-linked donor to the Asn side chain of proteins at the Asn-X-Ser/Thr motif.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MYEKVFKRIFDFILALVLLVLFSPVILITALLLKITQGSVIFTQNRPGLDEKIFKIYKFKTMSDERDEKGELLSDELRLKAFGKIVRSLSLDELLQLFNVLKGDMSFVGPRPLLVEYLPLYNKEQKLRHKVRPGITGWAQVNGRNAISWQKKFELDVYYVKNISFLLDLKIMFLTALKVLKRSGVSKEGHVTTEKFNGKN
The following text describes a protein:
Function:
Involved in 20S proteasome assembly.
Sequence:
MSDFTPCGSFSPSSFTSSTLILPVVSLGNVPQLTADLLIFSLGLKRVGFVGKGDTVTPFAGRGEKKGEIVTGGLEVYGREESQLYVIQQRSPTLKSQKDRHVSLLKTFINSNGFGAVLVLTSLDSAIQGDAQLSIPYQRVIPPGLRSLPNQIQKIQNIPPLSLSLSQPASSGQSISSSYPPFLPAAGLTRRLLAALSEEKTLIPHGAIAAWCVEGDNRGDARSFADVVLDVLDLQDVVQVQEPVSWEGLFGTTEGWSGGLGADAELYG
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles.
Sequence:
MSETDGEAEETGQTHECRRCGREQGLVGKYDIWLCRQCFREIARSMGFKKYS
The following text describes a protein:
Function:
Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRLRKYNKSLGWLSLFAGTVLLSGCNSALLDPKGQIGLEQRSLILTAFGLMLIVVIPAILMAVGFAWKYRASNKDAKYSPNWSHSNKVEAVVWTVPILIIIFLAVLTWKTTHALEPSKPLAHDEKPITIEVVSMDWKWFFIYPEQGIATVNEIAFPANTPVYFKVTSNSVMNSFFIPRLGSQIYAMAGMQTRLHLIANEPGTYDGISASYSGPGFSGMKFKAIATPDRAAFDQWVAKAKQSPNTMSDMAAFEKLAAPSEYNQVEYFSNVKPDLFADVINKFMAHGKSMDMTQPEGEHSAHEGMEGMDMSHAESAH
The following text describes a protein:
Function:
Methyltransferase involved in the biosynthesis of methyl anthranilate in response to stresses. Utilizes anthranilic acid as substrate. Produces exclusively the O-methyl ester.
Sequence:
MRIERDLHMATGDGETSYTKNSRIQEKTMFQIKPVLEEATRAVYTALHPQTMVVADLGCSSGPNTLRFVSEVIGIIARHCKEYGRQHDHTQLQFFLNDLPGNDFNNLFQLIQQFNKSTAINHKSEAAEALPPPCYISGLPGSYYTRIFPSESVHLFHSLFCLQWRSEAPEGNKKTCLDIYITKTMSPSMVKLFQQQFQKDFSLFLRLRYEELVSGGQMVLTFIGRKHENVFTGESNHLYGLLAQSLKSLVDEGLVEKEKLESFYLPMYSPSVGEVEAILKQVGLFNMNHVKVFQTNWDPYDDLESDVVHNSIRSGENVAKCLRAVMQPLVASQFGEPILDKLFKEYARRVAKHLENEKTKHAIIVLSIEKAIHL
The following text describes a protein:
Function:
Involved in the biosynthesis of phenazine natural products including myxin, an N(5),N(10)-dioxide phenazine antiobiotic, which has antimicrobial activity. Catalyzes the decarboxylative hydroxylations of phenazine 1,6-dicarboxylic acid (PDC) to produce 1,6-dihydroxyphenazine (DHP). Low activity with phenazine 1-carboxylic acid (PCA) to produce 1-hydroxyphenazine.
Sequence:
MTTATQTDIVIAGAGIGGLTTALALHAQGIERVVVLESANEIRPLGVGINVQPAAIAQLFALGLGEAIAATGIATRELRYLDHAGITLWTEPRGLAAGDPYPQYAIHRGELQMLLLAAVRERLGADTVRTGLRVQDFEHTRTGIRVHAQERGNGGSTVSFEATALVGADGLHSAVRARLHPDRCELLPARIQMWRGLTEVDEFLDGRSMIVANDDRSTRLIAYPCSARHAQHGRALINWVCMVPDVAQDLTREASWDCSGQLKDVLPYFADWKFGWLDVPDLLSRSTQILEYPMVDRDPLPRWGIGRATLLGDAAHLMYPVGANGASQAILDAVSLANELGDNSDTVEALQRYEAVRRPPTTAIVQANRDRDTAERAIATRPDPEKTAALAAITSSYRSIVDRSHVQ
The following text describes a protein:
Function:
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
Subcellular Localization:
Nucleus.
Sequence:
MKAGCSIVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRSNGVVPQSAPPVPTASSRFHFPPLETHSPTSDVQPGRFSASSLPASGQEPSNGTDRKVELSELEDGPAADWRRGVDLLSSRNAVSGGLGHPKRKPDIMLPLFTRPGIYPDPHSPFAVSPIPSRGGVLNVPISPALSLTPTIFSYSPSPGLSPFTSSSCFSFNPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQMHPEESAQFSIKLQPPPVGRKNRERVESSEEAAPVTVPTLAPVPPRIKVEPAPEKDPESLRQPAREKEEPSQDEGTVPSRTTEEEKGTIFVRPAAPPVWPSVPISTPGEEPLEVTEDSEDRPGKEPSAPEKKEDAVMPPKLRLKRRWNDDPGARELSKNGKFLWNGSGPRGLATAAADA
The following text describes a protein:
Function:
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
MLNPRCFLVCLQLFSVWQVGLPFSYYRPQRKLTEEIDWSYTETLNQENWAKKYPACNGAKQSPINIDEDLTQLNTNLKKLHFEGWDKESSEYTLIRNTGKTVEINLTNDYYLSGGALDSQYKASRITFHWGNCNATADGSEHSLEGQKFPLEMQIFCFNHNEFKNIDEAISGNGKIKALSILFKVGQEDNVRYNAIIDGVDNVHRFGTKVALEPFFLSNLLPDYTDKYYTYNGSLTTPPCSETVEWIVFKDTVTISESQLEMFCEILTMQQSGYVMVMDYLQNNYRHQQFEFSGQVFSSYTGTEEIPEPVCSSEPEDVRADSQNNTSLLITWRRPRVVYDAVIERYLVFYQHLEGEDQTKHEHLTDGYQDLGALIYNLLPNTSYALQVLAICTNGLYGKRSDQVIVDMTLDPQGADPFNDFTETEEDIQDSEEVEEENENESTRKSLSTVSNTNQKQAQGGQATTSSYSEGNAYLTTGKTADDKLKEHRDVLKAYLYPTLQTTTKTMHDTTVDYSGKSAEDAVMPQSVSEATTHLSKDFKSRVEIWMLNISDSTKSIAEEDEQTSADSELQTTTNWKRRILIPTRSPKPVSNHSTVSIPATAIYSSEITSQGNIVSSNIPDSDIDDAFTSTSEDISKVTAPVTEFDLYTISISTSKSNVVTEGQHPTNSINLLMDELLSTSFSSGATVMQATASSLEDVNKATLPGQEMPLVPNSTFSTPEVLLESVSAGFGNHDSESSVSEVLSQATLSQTTQPVSNGEIPLQPSFTSEVFPLVTPLLYDTKLLKATPASSDIDLILHATPVFPSVDVSVEPSLSYYDGTPLLAFSSAASASKVSRHLYTVSELFSQVPTDTLSLHDSLVLTESNTLLQPSHTYYSDVKPHQTIYGASETLTFDHGGHTFKSKKLITHLDSPNTELKLHALSMVSELTSPLSSDMASSESFAVSYDSSARDTVGILHQGSIIKYLGTEVLYRPSSISVQDISLQPTQSKLSNEDRSDTFSGSGFFNYGTDDLTEQSSVSSVGDVFKTNEFIENETVNKSDNIGKSNTGLQTVSAYGPVILHAGNEEVAGLSSSDAREYIFKVQQSSQETPPLSFSTPRSLDADINAASENLLPVEQINTLPTTSADISLKAMLPEVSTVSSSSNMLLSPTQELFYEVSDKPVSDLFFQNVLQSSGDISVSSKVTHAELLNDAPRSYNFSSNIDSSLLPTPSDTTIQSLLHSTYVTPVGNDLSPNSVASTVLQQSVLALHSHYVAPHLSATVNSGTSYANEKAEQTLDIEPTFLHAVSTPVLPTNTLTQDTTLNDHLPSSHYATHGIPAASRKYKDVTYSLSTDVTVNSVILPTVYVSVPAGFPNSESPSTLTMLTATSQTSSDTLPTVSFDTKMGPSVVDDGFIIASTYSTSHTEAQENVVADDSSSVHRVMLKNQTLSELSEQSEEGSAFSTAAVDNNIDSDMEGGSYLSTTMPMSSTGQKHIPFTALETHVQTHNTLLENTSESSSWAVLTDEESGSGPSTSDSLSDNETSTDFNFSDNNDRDKDYEVAIQPGKADLTPGSEMTSPPSVTSERSPVVNVSEADVANQEASNSSHESRVGLAEGLESEEKTVIPLVVVSSLTFICLVVLVGILIYWRNCFQTAHFYPEDKTSSRVISGPPIPVFPVADDVGAVPLKQFPKHVEDLHSRNGFTDEFEEIQNCTTDLGITSENSNHPHNKNKNRYVNIVAYDHSRVKLSQLAEKDGRTTDYINANFVDGYNKQKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPSDGNEEYGAYLITQKETKVLAYYTVRTFTVRNNKIKKGSQKGRQNERAVVQYHYTQWPDMGVPEYTLPVLTFVRKASATKRNGPVVVHCSAGVGRTGTYIVLDSMLQQIHHEGTVNIFGFLKHIRSQRNYLVQTEEQYIFIHDALVEAILSRETAVPETHIHGYVNTLLTTGPSGKSRLETQFKLLSEPNLLQCDYSTALKPQNKDKNRTSSVIPVERSRVGLSSLAGEGTDYINASYVMGYHESNQFIITQHPLLHTIKDFWRMMWDHNSQFIVMLPGMQNMAEDEFVYWPNKDQPIVCDTFTVTLVGEDHVCLSNEEEMIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPMSKTFELINLIKEEAANKNGTIIVHDEYGGVTAGTFCALYSLMHQLEQENAVDVYQVAKMINLMRPGIFTDIEQYQFLYKAMLSLVSTRQEEDSMVFMDTNGAPLPDGSTAESLESLV
The following text describes a protein:
Function:
Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
Sequence:
MAQQQRMQGQPMIIMGDDAQRVKDRDAQEHNISAARAVADAVRSTLGPKGMDKMLVSSMGDVTVTNDGVTILQEMDIDNPTAEMIVEVAETQEDEAGDGTTTAVAIAGELLKNAEDLLERDIHPTAIIKGYNLAAEQAREEVDNVAVDVDPDDKDLIRSVAETSMTGKGAELDKELLSSIIYDAVNQVAVETNDGGIVVDAANINIETQTGHGVNESQLLRGAAISKDPVHDQMPAAVEDADVLLLNEAIEVEEAEADTSVNIESPDQLQSFLDQEEKQLKEKVQQIADTGANVVFCQKGIDDMAQHYLAKEGILAVRRTKKSDIEFLTNVLDASVVTDLDAASEADVVAGSVTRDSDDELFYVEGESEQAHGVTLLLRGSTDHVVDELERGVSDALDVSAQTLSDGRVLPGGGATEVEVASRLRDFADSVSGREQLAVEAFADSLELVPRVLAENAGLDSIDTLVDLRSAHENDDDEHIGLNVLSGDLEDTFEAGVVEPAHAKEQAVTSASEAANLVLKIDDIISAGDLSTDKGDDDGGAGGMGGGMGGGMGGMM
The following text describes a protein:
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MSASNGSARCSRRKLFAPTPIGTSTSSRTSSHTASVAATSEHDSSLRTPSLVNGVESDAALAASMSASEVRRSYSLRRRTRTASTSSTSTHTHNATQSKSKRTSAKRSRAALSSCTASEEESDSAAGSDFCQDAANDTSDHDSDVFGDDSTTNRKNARASTSRKTSRKIKADDEKESSPKQQQQQRRASKSVSLSPKKRAASSPFSISPRKVSKKAWKVNLEAHEAHPAPLHWEEVYALLAKQRTRIVAPVDTMGCEENGRQHRRADAHRARESPEASAKRERLATLVSLMLSSQTKDPVTAEAVYNLQRTLPNGLCLQSLLDADNEMISQCISKVGFWRRKTGYLKSAARILADDFQGDVPRTVDELVSLPGVGPKMAFLALSSMGIQVGIGVDTHVHRLTNRLGWHKTKTPEETRLNLQSWLPTQLHANINRLLVGFGQVICVPVGPRCDLCDVGRAGLCPSFRKVDPKSIEKRVKVEMLASDHAGVALHHNSVKLKSESEHTAEARLKVELQVDDPHNTHILQVADLIKPQVDQQQIASISIKQEDDTDTVSVDKALDW
The following text describes a protein:
Function:
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
Sequence:
MLLNTIWGRKITSKDVAKERLQVVLVYDRAKIEPQLVEKLKEDLVNTVSKYLTFDSNNIKIELSSEDNKSILRIDIPLKD
The following text describes a protein:
Function:
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus speckle. Nucleus. Note=Localizes in nucleus speckles in presence of CBY1. Translocates to the nucleus upon cellular stress such as H(2)O(2).
Sequence:
MKAKRSHQAVIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH
The following text describes a protein:
Function:
Catalyzes the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12); involved in the assembly of the nucleotide loop of cobalamin. Also catalyzes the hydrolysis of the phospho group from alpha-ribazole 5'-phosphate to form alpha-ribazole.
Sequence:
MRLWLIRHGETQANIDGLYSGHAPTPLTARGIEQAQNLHTLLHGVSFDLVLCSELERAQHTARLVLSDRQLPVQIIPELNEMFFGDWEMRHHRDLMQEDAENYSAWCNDWQHAIPTNGEGFQAFSQRVERFIARLSEFQHYQNILVVSHQGVLSLLIARLIGMPAEAMWHFRVDQGCWSAIDINQKFATLRVLNSRAIGVENA
The following text describes a protein:
Function:
Binds the 23S rRNA.
Sequence:
MPKMKTHKMAKRRIKITGTGKVMAFKSGKRHQNTGKSGDEIRGKGKGFVLAKAEWARMKLMLPRGK
The following text describes a protein:
Function:
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
Sequence:
MSSCATSQDGEIRRSTKPEKEKLPKNVSKEIPIVPETSKGVAKKMVTIEAFTPSVLNNQIVAMRKIVKVAHLHTVRKTNRQLKNLKSRLEKKASEKMKKQIDKLEGDLVAMKTIKKDEVSKFALINKDSLDTLLNKPNTSPSERVLFKLATCPSVQSNVKAFRLSHPGSDVSCAFMLQRLGLQYQALRAEKVGDKLKKKLKSGEICDLTTESDAIKDEKTPQISSDQLEEKKEKSVIEKVLTKSIEKAKKEEKKTALTKKKKGEKMPEAPIIVKPIEIVKPVSKEAVVKKLNLRGDESDESDNEIDDDDDDDIDMESEDEMDDNSEEEDESEEDSEKEEGDEKSYEEEEEESDKEEDTTNDGLSAFFLNTDGTSREVITSEMKDVEDDEDEGKMRGGMRGMKTMRGGMRGRDREGKERMNGGDRGRGRDGNAQRVGRGRGSDRGRGGERGRGGQRGRGEKIDGSLGSVPSQSSSSSMGEQLHPSWIAKQKQKEMMKAGPSGKKITFD
The following text describes a protein:
Function:
May act as a soluble regulator of keratinocyte differentiation.
Subcellular Localization:
Secreted.
Sequence:
MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGVADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKSKLGFINWDAINKNQVPPPSTRALLYFSRLWEDFKQNTPFLNWKAIIEGADASSLQKRAGRDDQNYNYNQHAYPTAYGGKYSVKTPAKGGVSPSSSASRVQPGLLQWVKFW
The following text describes a protein:
Function:
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Sequence:
MSIADNLKQVLAELPQGVRLVAVSKFHPNEAIEEAYQAGQRIFGESKVQEMTAKYETLPKDIEWHFIGHLQTNKIKYMIPYVEMIHGIDTYKLLAEVNKQAAKAGRIVNCLIQIHVAQEETKFGFSPEECKDMLHAGEWKELSHIRICGLMGMASNTDDVEQINREFCLLNRLFQEIKANWFADSDTFRELSMGMSHDYHEAIAAGSTLVRVGSKIFGERNYNT
The following text describes a protein:
Function:
Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum (By similarity). During the vegetative phase, contributes to the highly polarized hyphal growth. Required for the reproductive cycle. Involved in conidiophore initiation and differentiation. May have a role in controlling the balance between vegetative proliferation and developmental morphogenesis.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Note=Late Golgi.
Sequence:
MSLDPSSFPRSNSPASSDSSLTRSRLRGKEGSLKKDKNYRRYASSVERALSLFDNTLQEWADYISFLSRLLKALQTHPPDQPVVPHKVLVAKRLSQSMNPSLPSGVHQKALEVYTYIFNLIKPEGLSHDLPLYYPGIAPTLTFASLTVRPLFLSLVETYVCDLEPWAIRPALKAIILSLLPGLEEETSDDFDSTLRLLNTLREIASRMDTQRPGAETNSSGQYFWQCFFLASITSPSRRLGILAYLNRYLPKLGVTDRRPSRHEEVDATAMPLEMQVAVDSVILPEPGLLIRCFATGLTDEQVLVQRNFLDLLVTHLPLSSPILQTRITKDDLQRLIVAAAGVVSRRDMSLNRRLWAWLLGPDPVGDRASFEARPSISSTASKTAAESEELSQSQYFSRFGLQPLASGLLQLLKRDTELPSEKAKPFRITLSLMDRWEVGGHVVPAVFLPFMRSVKAYKLAAPKAHFDEVFRSATSFFDGVESGMIFSELLNLIDWDAKSLANDAPRILDNLNLAHFILDHFNVREEDMVLNHAPLLTLAALIKMSELSSEATTSVAHDQLQAVSNGLSKVVTLLTGLLIDRAFLRKSDSKNSVNEPSMLLDRPGSAILRQIHQFYDRSRNSLDLQPPPFPPTDLADLIIKNVYEQAISAVNACNDAKSIPERLNLLIVVLKKLPRSRILRDKRLYVAIGKHIQASTVELSTASFSHLSSMSTTITSLYCIHKLGYYITYEEVSDLIPPLVRQLWQFLSPLSPKFHVEAVRCLWNLHSVSWSDHLVESTITSLMFTPPAPGSYQLSSEEEAGRYFILWNHSHHGTYELPPKNLQDSAQSQASYHSSMLERPLFTVLDLLSQGSTQPAQVVQLWLQDLPSVAKVFRIIISKLEGVLHRGNQLGTFEGNTVVSPDDYAECNYLFETIHNVLGALNHNGWVSLLTQTMAHNSRRHDASASEDNAEAPSLHSVVFQASLKIVSGYKSGTATANAEEVKLQQISLLVMRQLLLGPGVEELVESGIDSLLVDRLYSMLDEGGDIAIQAALIDTLLAVLKARFSQAYLPPPPTKPKHQRGGSREKLTSPSLLSFTSDKPEKSSVLLPSPEPPQRLLDCLLKGLSSPRSRAIIDKWIMLLCEILPIYSTCIFQILLTLVDCLGREIRQSYTNLQSAFEKTEGWPKDRPEQTTISLLTGFETCIAAAHERLLMEEVNAPAAKSPDQTHGFFGNMVSGVFASDSNHPRSAAMNNRLTVLLSFQDAVRLCFSIWSWGAAERSSLPQDTESIASFQYTSLRMRNRSRRILEHLFTAEALECLETMVDMWIKSDRDTSPLIFNLLHTLDGSRPKIAIPAIFNAIYTRTNPAALDPSRKSTMTTALTETELAGFLVTYARSLDDDVLDEIWIDCTTFLRDVLSNPFPHRQILPRLVEFAAILGVKLENTNFGEDRRMRKELGDVILRLLTAIFTSKPMGFTQEQGLLGRASLDYDSSSIQRIGPDDMLSILVASMPAFSMTLGDMDRITTAVSNISTNIIGPFIRARLFPNNLNTSFMALMQHISKIPQVAKVWKKDVADAFNDPRFFGSQLDLVKGGWMTLLRQWALVDKDRLSEIMTRLTPPATAGIMFGVGASAARLDADRKAQLNLRRISLLVLSTAEDYFIAEMPALLQKLEDLLGATASSSPSSATRAEIFMVLRALILKSTTTTLSPFWPLINSELQEAISAISSGNQQELYNPYSLLQACKLLDTLLVLAPDDFQLLEWLYVTDTVDAIYPPEQFEPTALADEVSHNLGVRWSTSSDPTRESTNLHHGVRYPGLAADWIRETAKDEIVDRVLRPFFDQLSIHAFESTYSISNPNLEACRDDLLADLFNESTMAN
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs.
Sequence:
MAVTNFHYITRMNSGFKVYILEGQPSLRTEDRYRHLAHRAGVPPVYPIKRKHSPERGPAVEDRAVKVRRSSLALISKERALFGSATRSFQRQPSLSPATPPQTPTVTTTTRSPARRLPSPLYAGPPMDEPLALIKKPGYCSPTEGTVPSMDAKPHSPTTTRVQIRPSVITCVSSSARAASSSPEVRSSPCSSASSPPACDPVVEEHFRRSLGLHYREADSSALPVSVSVDDHFAKALGDKWLKLRASSSPGSPSYGSSPSRGYSPHSPHSPAGTSSP
The following text describes a protein:
Function:
Transcription factor involved in the regulation of gene expression upon nutrient starvation. Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region. Can act as a transcriptional activator (e.g. of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e.g. of pyrophosphate phosphatase DPP1). GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1.
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MEIKPVEVIDGVPVFKPSMMEFANFQYFIDEITKFGIENGIVKVIPPKEWLELLEGSPPAESLKTIQLDSPIQQQAKRWDKHENGVFSIENEYDNKSYNLTQWKNLAESLDSRISQGDFNDKTLKENCRVDSQQDCYDLAQLQILESDFWKTIAFSKPFYAVDENSSIFPYDLTLWNLNNLPDSINSSNRRLLTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILSKEPSSNKENCPAFIRHQNIITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYNFGESIEFILDQQAVVRKQPLKCGCGNKKEERKSGPFSNLSYDSNESEQRGSITDNDNDLFQKVRSFDELLNHSSQELQNLEDNKNPLFSNINMNRPQSSSLRSTTPNGVNQFLNMNQTTISRISSPLLSRMMDLSNIVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNSLLSNITATSTNPSTTTNGSQNHNNVNANGINTSAAASINNNISSTNNSANNSSSNNNVSTVPSSMMHSSTLNGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLSSPMNPNGHTSYNGNMMNNNSGNGSNGSNSYSNGVTTAAATTTSAPHNLSIVSPNPTYSPNPLSLYLTNSKNPLNSGLAPLSPSTSNIPFLKRNNVVTLNISREASKSPISSFVNDYRSPLGVSNPLMYSSTINDYSNGTGIRQNSNNINPLDAGPSFSPLHKKPKILNGNDNSNLDSNNFDYSFTGNKQESNPSILNNNTNNNDNYRTSSMNNNGNNYQAHSSKFGENEVIMSDHGKIYICRECNRQFSSGHHLTRHKKSVHSGEKPHSCPRCGKRFKRRDHVLQHLNKKIPCTQEMENTKLAES
The following text describes a protein:
Function:
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal zinc finger binds to poly(A) RNA; Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the pan2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of pan2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs; The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for pan2.
Sequence:
MASAGKPALDDSRRGTGSPKIKGRENAKDTLCRNITIYGRCRYEDKGCAFNHDPHKVNSSNQSDSKKRFNVDSPSFTPSLLSSNGSSPTSTPATTKKMTTISPKAANAAPFQPRSVVSRSNASTPGLRQDTVTPDWTVAEVQEFVPQGFDNSHLAALQGNGNGPITSTSPFDPFVTTPTPLSAGGAVGPVQPNPYSHDAAAALGGAAFFPGAAGFQQPVQYHLYAPIGPHNQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQIDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNYYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLGAGQQRFQGRHNVQHIPEQILWGYMTQIANALKAIHSNGLAARVIDASKILLTGKNRIRLNACAIMDVVQFDSQRTVADLQRQDLVNFGQLIVTLGANSPTVMHNPTKAMEHFTRAYSPQLKNSVFWLLNGMQKDQDRNIDVFITGISSQLMSTFDSALHLDDQLTSDLSRELENGRLVRLMAKLNFVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDAQGDPVVDLGHVITCLNKLDAGTEEKITLISRDEQSCFIVSYKELKKALESSFQALMKPARRMH
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MPVPAVTTSAAGSLTLLEDPDKDVRVYALNHLLSIVGQFWAEMSDKLPYLELLADPLSKELAPENRPFAALLISKIYFYMGFQDEAVEFALKAGVAFEKESEGEYRETIIAGCLDQAIDKTQKGEDIPADLQSIVDSVLRSSSGENAKLAMGLALSLRRLDLIEMIYLSSRGPSQASSSKSERVVHDENLLRYVLAEVVSGTSGNEAWPEDFRANLFSLLRRLFHLNPNPDWNSITTVWAQSSDVESTVESLVKLLEVDDNLTVYQIAFDLTEVASQAFIDEVREKLGETKWAAPVDGSEDDVRVVLNNILRGDTSAELFLNFLSRNNKTDMSILKVTKETLEDRYSIYHSAITFTNAFAHCGTTSDKFLRENLDWLGRASNWAKFSTTAALGLIHRGSWVNGNRVVKPYLPGGAAPNKYSEGGALFALGLIYAGRVEFAEEELKKGLAEGNDPLVQHGAALGMGVSALASADDEIYDEIRPILFQDDAVAGEAAGYAMGLVMLGTASERALEEMLSYARETQHEKIIRGLAMGIAFLMYGQREAANPVIQRLTEDKDAILRYGGMYTIALAFAGTGNNKAVKKLLHVAVSDVNDDVRRAAVTALGFVLFRNHTTVPRVVQLLAESYNPHVRYGATLALGISCAATGLESAIELLEPMTKDPVDYVRQGAYISLAMILIQQSEAACPKSITIRELFAKVVADKHEDPMARFGASLAQGIIDAGGRNLTLALSTRAGTLNQNAVVGMALFVQFWYWFPLAHGLGLAFTPTAVIAIDGKMKVPQLELECHARPSLYAYPATEKKVEEKKKDKQKAAVLSTTARAKARERVKKAEAGEVMETDDKAEESGKGKDAAPTPKKSKPSEPSSFKIPNMSRVTPSQLAYVTFPTSGRYTPVRPLDHSPLSGSNINGKPSTLASGASASGSIVVLRDEKPEEPAEYIELSKELWPGWLPANPEAAAAILAQATAEGSGGAPGSGVTGQAQQQQQEPEEEAEAPPAFEYPFEDE
The following text describes a protein:
Function:
Catayzes the decarboxylation/dehydration of prephenate to phenylpyruvate.
Miscellaneous:
MISCELLANEOUS: Present with 2020 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MASKTLRVLFLGPKGTYSHQAALQQFQSTSDVEYLPAASIPQCFNQLENDTSIDYSVVPLENSTNGQVVFSYDLLRDRMIKKALSLPAPADTNRITPDIEVIAEQYVPITHCLISPIQLPNGIASLGNFEEVIIHSHPQVWGQVECYLRSMAEKFPQVTFIRLDCSSTSESVNQCIRSSTADCDNILHLAIASETAAQLHKAYIIEHSINDKLGNTTRFLVLKRRENAGDNEVEDTGLLRVNLLTFTTRQDDPGSLVDVLNILKIHSLNMCSINSRPFHLDEHDRNWRYLFFIEYYTEKNTPKNKEKFYEDISDKSKQWCLWGTFPRNERYYHK