lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity.
Subcellular Localization:
[Processed angiotensin-converting enzyme 2]: Secreted; Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, cilium. Apical cell membrane. Note=Detected in both cell membrane and cytoplasm in neurons.
Domain:
The cytoplasmic tail contains several linear motifs such as LIR, PDZ-binding, PTB and endocytic sorting signal motifs that would allow interaction with proteins that mediate endocytic trafficking and autophagy.
Sequence:
MSGSFWLLLSFAALTAAQSTTEELAKTFLEKFNHEAEELSYQSSLASWNYNTNITDENVQKMNEAGAKWSAFYEEQSKLAKTYPLAEIHNTTVKRQLQALQQSGSSVLSADKSQRLNTILNAMSTIYSTGKACNPNNPQECLLLEPGLDDIMENSKDYNERLWAWEGWRAEVGKQLRPLYEEYVALKNEMARANNYEDYGDYWRGDYEEEWTDGYNYSRSQLIKDVEHTFTQIKPLYQHLHAYVRAKLMDTYPSRISPTGCLPAHLLGDMWGRFWTNLYPLTVPFGQKPNIDVTDAMVNQSWDARRIFKEAEKFFVSVGLPNMTQGFWENSMLTEPGDSRKVVCHPTAWDLGKGDFRIKMCTKVTMDDFLTAHHEMGHIQYDMAYAVQPFLLRNGANEGFHEAVGEIMSLSAATPNHLKTIGLLSPGFSEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKEQWMQKWWEMKREIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTRTIYQFQFQEALCRIAKHEGPLHKCDISNSSEAGKKLLQMLTLGKSKPWTLALEHVVGEKKMNVTPLLKYFEPLFTWLKEQNRNSFVGWNTDWRPYADQSIKVRISLKSALGDEAYEWNDNEMYLFRSSVAYAMREYFSKVKNQTIPFVEDNVWVSNLKPRISFNFFVTASKNVSDVIPRSEVEEAIRMSRSRINDAFRLDDNSLEFLGIQPTLSPPYQPPVTIWLIVFGVVMGVVVVGIVLLIVSGIRNRRKNNQARSEENPYASVDLSKGENNPGFQHADDVQTSF
The following text describes a protein:
Function:
Transcription factor involved in sterol uptake and regulation of sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters and regulates transcription of ERG2 and ERG3 in response to sterol levels. Seems to be involved in activation of DAN2 and DAN3 cell wall mannoproteins.
Miscellaneous:
MISCELLANEOUS: Present with 79 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTSDDGNAGQEREKDAELIEVGGKKVSKTSTGKRKFHNKSKTGCDNCKRRRVKCDEGKPFCKKCTNMKLDCVYSPIQPRRRKDSSSSKFASAVHDRVGKKNLSDNAIMLQQQQQQLHHQQEQQFRQQQQVQLQQQLLPHVGTDEQSNSPNSVPPSVSNNMENLLLPHLLASLVNNTSNSTNSSANGAEAHNNITQTAPSSMINNNHPNMALPGNSPLSIPITPSFQSTAMNLSSSLNGLLSPGRLNSVTNGLQQPQLQQQNQQIPQQQGTQSPFSNIPFDQLAQLNKMGLNFNMKSFNTLFPYGAANGMASEFQELFGLGKFATSNNRAIKVSTAEEALANMQQEQEDKNKQFTKNPLDNTKTDAVNSGNNPLNGNENKVTASDILSHNKNLIIDNTGLTISPPHTLSKPSIDQNIASPSTGVSNVTSTKSLLSIPDNRTALGNSPTLKTSPMGDLLSNSEALSPRSSNSHTQQQSSPHSNASSASRLVPELVGLSRKSNLNLIDLKLFHHYCTDVWHTITEAGISGPEVWSTYIPDLAFHFPFLMHTILAFSATHLSRTEAGLDNYVSSHRLEALRLLREAVLEISDDNTDALVASALILILDSLANASSSSPTAWIFHVKGAVTILTAVWPLSETSKFYNLISVDLSDLGEAVINQSNHNNDNDNSNNGDGNNNNTISELVCFDESIADLYPVEIDSPYLITLAYLDKLHREKNQLDFMLRVFSFPALLDRTFLALLMTGDLGAMRIMRSYYTLLRGYTTEIKDKVWFLDSVSQVLPQDVDEYSGGGGMHMMLDFLGGGLPSMTTTNFSAFM
The following text describes a protein:
Function:
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
Miscellaneous:
MISCELLANEOUS: Strain 2-2-12 is a substrain of P2 that is highly susceptible to infection by Sulfolobus turreted icosahedral virus 1 (STIV-1).
Sequence:
MKCPYCKTDNAITYDVEKGMYVCTNCASVIEDSAVDPGPDWRAYNAKDRNEKERVGSPSTPKVHDWGFHTIIGYGRAKDRLKTLKMQRMQNKIRVSPKDKKLVTLLSILNDESSKLELPEHVKETASLIIRKMVETGLTKRIDQYTLIVAALYYSCQVNNIPRHLQEFKVRYSISSSEFWSALKRVQYVANSIPGFRPKIKPAEYIPKILYKLNLPPIIGTKASELVDLMHKQGLTSGKGYLSLSAASVYLISALMDIKKTQKEVADSLDITEVTIRNRYKDIVDNFDIVVTL
The following text describes a protein:
Function:
May play a role in flower development.
Subcellular Localization:
Nucleus.
Sequence:
MADPPHFSLFQQKFRTGDKPFLTLDADFLMNHTKVLLKSDASDKVWKVKLDGGRLSEGWEEFACDQKFRDGDVLVFKHHGDEVFHVAVVSPSVSGDIRNASSSQVITEDTYIDVDDVDDDDYGQDDEDDDDDDDEGEDNIENISEKTDKRQEADSSSDHSGFITARVTRYSLLHDRLDLSRNFTLLFGGHQKTCEIDVVDEQGRRWTMKLAKNISSGVFYIRLGWGNFCCANGLTQGDLCKFKLFQNEERPVLWLCPQESGNGRKEKRTFDEVSKGKEKKTPSPFLIVKYTPSRETTGQLSLPVSFTRNNSINKTGEVILLNQDGRKWSSYLQITGLGRGAGSEWFYLRRGWREMCEANGVGVNDSFKLELVWEGANPMFKFCSKIENHEYKGKGNQRTRKKRACETAPQPRNVKKTPRLGVEGPVYQVDEERGHTQVSNRTNTISGNLQRLLPPSCSVSDQVANVKQGIVDSLNTVRQCRTELETSEQNLQASLLAIDALGERIWGISKILSSNLV
The following text describes a protein:
Function:
E2 ubiquitin-conjugating enzyme that catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short-lived and abnormal proteins (By similarity). Mediates ubiquitination of PEX5 (By similarity).
Sequence:
MSLKRINKELSDLGRDPPSSCSAGPVGDDLYHWQASIMGPPDSPYAGGVFFLSIHFPTDYPLKPPKIALTTKIYHPNINSNGNICLDILKDQWSPALTISKVLLSICSLLTDANPDDPLVPEIAHIYKQDRKKYEATAKEWTKKYAV
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAYYNDFGPRPFDRHDDPYIPPDIDGPPPSNFPFRSEYPDDHQMWDRPSPPSFRGAPDYERGPYSSTPGDYHMYPPGSMGGGMRAEDYIPQVFPRMGSPEGYPSDYPPVRAPPFAPDYERGPPPGGYADDYGRRPPPGYPGGDYDRPLPYEYEMVQTDFGGYERRPILPGYQRERPLGGYPPAEHGRWHDPHQRHGPPVHLRDGGRYDAGAGHPPRSYEPEVRFNRPESPRRPQPPIVAYPPEQVKSPPRPSGGGDGGGQFPPMPYEPAVAAADPPPPPMKQDRAPEGEPQFPPMPYEPVHRSPHHHHEGPPPQRSPRMNPRDDDVAVPYHAQMGIPPDQPFQQAHYGHATEHGHIKRKHLQGCKDYWAAFIFFFHFWAVVGVCIYLGVRGVIKTNENEDLTRHSIFAPSPPVSDRLYSIKHWAPQLAAAAGSGWLFAMVWQHVVRSATMIKACLALGAVATGLLGIILISTGTTIGIVGLIFLVSALFQGLYVHLVRERIPFAACMYKKTRDVLRHYKGLYIISAWHVLLALAWLALWIFGVSGAVSLPHGGWYAALLVLSLAWSIEVLRNIVYVTVAGLVGTYYYEARHMPHVPTLRALQRAWTISFGSICLGSLFVAPVQTLHCLAKRLANEQGENEFMFSCVNCFLGVLNFFMRHFNKWAFVNVGLHGNSFVKSARRTWDMFENQGAMLLINDDLTGAILLSSCLIGGVLTALVGGCWTFATHSHLTVGVSIISFFIGFFVTYLTMVVRESAVAAYYVCFAEDPATLKKIDEAHYQYMVERKRQLDQQIA
The following text describes a protein:
Function:
Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryonic development. May be involved in maintaining the identity of cells of the dorsal-most neural tube and of at least a subset of neural crest cells.
Subcellular Localization:
Secreted.
Sequence:
MDALRAVAFYALFVFLWSLPCCQSAALISQKRSKGARSAFDGQRSHKFLKEILASSPGASRRDDFKDPVVPHDYMISIYRTYSAAEKLGLNASFFRSSKSANTITSFVDKGKDDLTLSPLRRQTYLFDVSTLSDKEELVGAELRIFRKSPGDVQPSPSGVYNLHLLSCRSERPLASRSIDLQDSRKAEWEVLDVWGIFKHRHQENQLCLQLKVTYGKSDTEIDLKQLGFHRHSRTQQERAILVVYTRSKKRENLFNEMKEKIKSRGDDDEEESALQFKARRRRRTALNNRHGKRHGKKSKSRCSKKALHVNFKELGWDDWIIAPLDYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPNSTPPSCCVPTKLSPISILYIDSGNNVVYKQYEDMVVEQCGCR
The following text describes a protein:
Function:
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells (By similarity). In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips; The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses.
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein. Host endosome membrane; Single-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection.
Sequence:
MDRGAVVGFLLGVCVVSCLAGTPKTSWRRVSVGEDVSLLPAPGPTGRGPTQKLLWAVEPLDGCGPLHPSWVSLMPPKQVPETVVDAACMRAPVPLAMAYAPPAPSATGGLRTDFVWQERAAVVNRSLVIHGVRETDSGLYTLSVGDIKDPARQVASVVLVVQPAPVPTPPPTPADYDEDDNDEGEDESLAGTPASGTPRLPPPPAPPRSWPSAPEVSHVRGVTVRMETPEAILFSPGETFSTNVSIHAIAHDDQTYSMDVVWLRFDVPTSCAEMRIYESCLYHPQLPECLSPADAPCAASTWTSRLAVRSYAGCSRTNPPPRCSAEAHMEPVPGLAWQAASVNLEFRDASPQHSGLYLCVVYVNDHIHAWGHITISTAAQYRNAVVEQPLPQRGADLAEPTHPHVGAPPHAPPTHGALRLGAVMGAALLLSALGLSVWACMTCWRRRAWRAVKSRASGKGPTYIRVADSELYADWSSDSEGERDQVPWLAPPERPDSPSTNGSGFEILSPTAPSVYPRSDGHQSRRQLTTFGSGRPDRRYSQASDSSVFW
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKGKIIVAMSGGVDSAVTAGLLMEDGYEVIGVNLRTWEYEAPACDTTKKSCCSPEDIRDARDVGISLKIPFYVIKMEKVFQEKVIDRFIEDYQHGKTPNPCVECNTFVKFGALFEKAKALGIDKIATGHYARIARNGERYAIANGIDVGKNQAYYLYGLSQENLKNVIFPLGEMTKPEVRQIARRMGLPVADKSESQEICFIPENDYRKFLEKKNVEFTPGFFKLKDGRIVGKHKGRENFTIGQRKGLGIAWKNPLYVISIEDDGSVILGEENETYNESFSVIDLNFQGLAPLNEGESLECRVQVRYRHIPIRCKITKMKEGLIVHPLEDVRGVTPGQSAVFYPLDSDYLLLGGIISKGSIQMRIVEPAISVLN
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MLKQLYFFLVCLLWTTVNASRFDVEHALVLYDPELLPLNDTSSLTPEVAQFIEYLSDKFDVKISDYNSEDINLFFDDYPRYEHLVLFPSSKKTITSKEALSSHNLLRFINENSNIFVVGGSQSVLPDGLRGFLNELGVFPSPKNYKYIDHFNSKNGVVQLNRDNVVEGNRLVQELSVTKYDGNAALISNNELIFPIVRSSATGYTNKVGEPIDADKTWTFGEQGYLAVGFEALNNARLVWVGSNSLLAEPQLYKWCFQQQGKLKLQFVEHIKADEPSKPNPHLYRIKDQAIYTIGVSEFVDGKWIPFEVKDEKDQLQLSFKMLDPYQRLNLKPLGPVSAISNSTELDTYAYFVNFTVPDHHGMFTFELDYKRPGLSYLVDKRVVTVRHFANDEFKRSWDISNSWLYVASAVFVIIAWFVFVVSYIYIGKSNYSKKNV
The following text describes a protein:
Function:
Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSAEDEAREDARRDYQSSLEDLTFNSKPHINMLTILAEENVQFAKDIVILIEAQIAKARATEKLPVMYLMDSIVKNVGRDYLAAFAKNLVTTFICVFEKVDENTRKSLYKLRSTWDELFPSKKLYALDVRVSQIDPAWPVKPLPPNVNTSSIHVNPKFLNKPEESPPAKASAPSPAPPRAANSEAQKHLSQEQLIRQQLLVKQKQLLELQQKKLELELEQTREQLATSLSSSKPVVSPKIPHMPVKAPPPVSEKSKVPAPTQRIEKSHEKMPVPTRDPRLVKGNQHSAHGKDQGHKKEMKSNMACMPDLKPIKPLLNDKANASAKQEKAKSNEKLPKRELVQSELKDRSKSPSPLKAKLSHMRDKSQGTENVRDLDISRRDPRLHKHLRNKSDDKDAEPKEKRKCDKKEEHKSEHRVAGNRNKPVNGIVPKNETSTNYPDKTKPGRIGNRKRSRSPKSRSPAHSPKGRDRRSPKARPRSISPVHSLPKIGRLRQPGSKQSHTEDFNASSREERIKRNAKTDARDGRRQKRLSEERPQDPVSLISNKSNTEPKEDIENWQGPKANKRWKSGWEDNKNSQNDDHQGNRPPYQRHNSWQNSTKGVASPRAPKQQHWLSVDADLKIPKELTSASKAELLKKANERFSLGEITHDELLVVVHQIRQLFQYQEEKQRGSVWDSPTEENKGALRKKPLLSNPETTYYEHKAKLKRTQVQHAFADREYMDPEYLDMELDEMAHSGRDGELSGRAEDKMPERNEQFPERQRLSPLLGTRHPDEDAHDGYRRHEDQRELSKGLREEPRPLFPERFPRSVPMYDESEEAPYEENADSRMSGNKANPKLPLMEERRPLLDIPPLIPVNRGDAPILKSFEEPSNVANVRESSPVNACMPFDGASGNQVGPQRFEAVSGQPVDAHFDSMGANQVENTRFDGMMGQPKNHQGPQGMQKYDGAQNQPIVSSQPVGVKRLEGPPGQPMNAARFEGPPSQQLGAPRFEGAAGQPVGPQRFEGMQQLGPQRFEGVAGPQRFDGSPRPLMQQRFDGIPCQPMRFEQPMRFEASQGQQLGPVRFEGPVGPRFEVNQPQRFDSGPGPQPLMRFDGPMGQMRPRFDGTPGNRFDNQRPHMQRFDMPGQPCQRFEGPGPGHQTPPRFDGPMQVQPRFDGPLPQRFDGPNQQPRFELSMNHQGPRFDNIHPPVRQNAPPFGQSGPYGEPQNHFHGQPQNMPPQGLPPQGMLPQGLPHQGMQPQGLLPQGMLPNGMQPQGMLPQGMPPQGIPPQGMQQQGMPLQRPEQRFDLPQGPNFAGPSGPGVQCFPNQLPRPSGPYFDDKNPKPQGPQFANFNNLPVGNLAPSQPFGPLGGMSQPAGISQPTAISQPSGMSQPAFSSQDQNYVPPLGSAGGVFVQPGGSFPFPENHLGQLDVNELFSKLLSTGIIQKVTPNETSSTQATESSAPAAAEEEEEDADGDGDEDQDVPDLTTFQMEDLKQRYDSVINRLYTGIQCYSCGMRFTKSQTDIYADHLDWHYRQNRTEKDVSRKITHRRWYYSLKDWIEFEEIADLEERAKSQFFEKVHEEVILKTQEAAKEKEFLSVPAGPAGADEICEICQEQFEQYWDEEEEEWHLKNAMRMNDKIYHPSCYEDYKNTSSFLDSTPSPSKTLLENPLNAMLNLVKEEVTEPTCSVKEEPADYTASSCCEIPLLTEIKKEPAEPE
The following text describes a protein:
Function:
Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the second beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan, and in elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MFESDLSFYSALLILCCPISIVFFKKFPIKGYTGANKVSLFLQCLIAILNLNILYSFINSLTITLGHDGSSANTLTIDPITTTQQQGHVDYTPIKVSGYTFKNQVATKNLQCDSIVYDQDLDLQVSQAVDLNKPEDLKFFRDKLNELRSLNNIYDLFFQDNEDEVEESILERKWYKFCGSAVWLDKYGVYFMVNRIAYSKKGTRNNPTISVLAGQVFDKNWIELTGKKFPFSGLEFPTILPHYIDEGKEAEKVILGAEDPRVILHEYTNENGIRIQEPLIAFNALSTEVDWKRAMHIYRPLHDPHRIIRLSIENYAPREKEKNWAPFIDGNNLNFVYNFPLRILRCNINNGDCQKVSGPDFNDKSHENAGKLRGGTNLVEIPSQSLPKHLRSRKYWFGIARSHITDCGCVGELYRPHLILISRNKKSDQYELNYVSDLIDFNVNPEPWTPGKTTCSDGKSVLIPNSVAFIKDDYMSVTFSEADKTNKLINAKGWLTYITKMLEFTQERLKDESSDPVLESRLLSKCSTFLAQQYCALSKDTMGWDKLSR
The following text describes a protein:
Function:
Putative oxygen sensor; modulates the activity of FixJ, a transcriptional activator of nitrogen fixation fixK gene. FixL probably acts as a kinase that phosphorylates FixJ.
Sequence:
MTATFASLNRIILAHAFSFNWASMTVLSTTTVPGSAKRSMHDDEQLAILASVLRTAVDAIIIIDQRGTIESANIATERMFGFSPGEMIGQNVKMLMPSPDHEQHDGYLERYQKTGERHIIGIGREVTGKRKDGSLFPLHLGVSEVETDQRKLFTGILRDISELKAAEAELKQLNATLDQRVKAQAAELQQAQLELVEKEKFATLGRISGGIAHEIRNPLNAIKTSAYYLLNAQTPSPAKTQEHLTRIDRQVTVIDSAVTALSDLARLPEPQASEIDLKAMITGILRETKLPGNVTVQQHFTEELPRIWADEKQLPIVFKNLLRNARDAMPDGGSLILSARVDEPFVVVTVRDSGIGMPPEIAQRVAEPFFSTKARGMGLGMAITTAILEKNQCKMRLESEPGRGTSFDISIPIAGQSR
The following text describes a protein:
Function:
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MLLVLTGVTAVSVALLAYVNELTKGPIAEANAKTLNEALKKVLPEYTNNPVAESDTVFSEKDGKKIVDFIIYPAKNGEKWVGSAVEAKSMGFGGELKVLVGFDAEGKIYNYSLLAHAETPGLGSKADKWFGAYDPAKNEKPVSHEESAKSILGMNPGETPLAVTKDMNGQVDAITASTITSRAFLNAVNAAYQAYKGGEVDTNSGASQKNEPAVAPEGEAAANDTNN
The following text describes a protein:
Function:
Confers resistance to the antitumor agent cisplatin. Binds preferentially to sites of DNA modified by cisplatin in vitro. Binds to double-stranded DNA in a cooperative manner resulting in the formation of filament-like structures. Binds to single-stranded DNA with no cooperativity. Binds to RNA.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleolus.
Sequence:
MAEVLEFRVPAGSAQTLLVWGLEPTVGLEHSLFSVFSKFGLLYSVRVHSNAAVAGPGCYAIIKFYSAADASRAQHACNGQRLFQNSPLKVCVCTKQKGFQQQVLALNSNKCQELANHYLGFNGWSSRIITLQNVSGFDDENEEVGKKRSVRYLCAVEVTLPNHGVRTRGVGLGEADVESGEDPLEFGTATRRVQKLAVGKALSSAFQKILLVVLESGKVAVEYNHAAEEPTDSLTEEELEGLVQVSELPLEPFDLEEEVLSDLTLDDELPVWEVPSN
The following text describes a protein:
Function:
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKIPGSVITLLIGVVITVVSLWYGQNHGLMPVAASADAEKVDGIFNYMMTIATGLFLLVEGVLVYCLIRFRRRKDDQTDGPPIEGNVPLEILWTAIPTVIVFTLAVYSFEVYNNLGGLDPTISRDNAGQQMAHNHMGHMGSMGNMVAMAGDGDVALGIGLDSEEQGVNPLMVDVKGIQYAWIFTYPETGIISGELHAPIDRPVQLNMEAGDVIHAFWIPQLRLKQDVIPGRGSTLVFNASTPGQYPVICAELCGAYHGGMKSVFYAHTPEEYDDWVAANAPAPTESMAMTLPKATTAMTPNEYLAPYAKEMGVQTEALAQLKDQTSPVGDLL
The following text describes a protein:
Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Subcellular Localization:
Secreted.
Sequence:
MAAALPRRSAGPAASGPWSLSRRLLLLLLLLHSGYKENTSTPVCGKPWWSGDLDVIRHWPWEVSLRLENEHVCGGALIDLDWVVTAAHCIQGTKEYSVILGTNKLKPADSLRVTMIPVKDIIMHPKFWGRTFIMGDVALLQLHRPVALSKYVQPICLPEPSYNLKVGTQCWVTGWGQAKQRFSVNSTLTPELQEAEVFIMDNKRCDQIYRKKSFIPHIVPLVLGDMICATNYGENLCSGDSGGPLACEVEGRWILAGVLSWEKACAKAENPESWFQTCGHTNIACKMVKGKLVEVGKWPWQVSILLLGVYICSGSIIHHQWILTAAHCLQRSKDPKMYSVMVGVQRLPENSTQLLLTRIVIHEDFHNLISQDIALLKLRAPISWSPLIQPVCLPSSRFEPSIGTLCWVIGWGYKNPQVSSVTPKSPYSLQEVAVKIINSEICRQQYQFLFLKDQKQFIGNDMLCVSSEWGMDSCQDNSGSSLVCQVNNSWIQIGVVSWSLSCNRHRLPSIYTSTSQFTHWIKRQISDMRFISRGDPAFLSPVARTGYILLVSLGSLWLL
The following text describes a protein:
Function:
Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.
Sequence:
MAVWGLGSRLGLRGCFGAARLLYPRFQSRGPQGGEDGDRPQPSSKTPRIPKIYTKTGDKFALELVTEKGHTFAEELQKIQCILQDVGSALATPRSSAREAHLKYTTFEAGPILELEQWIDKYTSQLPPLTAFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDVNVAKFLNRLSDYLFTLARYAAMKEGNQEKIYKKNDPSAESEAL
The following text describes a protein:
Function:
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MMTFSLQNITHSYHVATPVLEDVSIHIQKGKVHALLGMNGAGKSTLLKIATGEIQPVVGDIKIDTQSVSFTSPRDAKKHGISFVTQEVDHGLIPGLSVLENVLIDHLAMQNKVLFSKSKLVALAKQHLQTVQVNLNVSEDVSNCSLHEKQLLLIARALSNNTNYLLLDEPTSSLGPKEVETFGKLLKDLTSKGIGILLVSHRLSEIRNFADDVTVLHNGQVALSETITTITDQQIVEAMTGKQLTLPINTAPKTGSEELFKVQELLLHEGHSPLSLTIRKGETVVIYGLIGSGKTTLAETLFGALHTYHAEIAGQKLTIKTPRDAIKAKIALVPEERRKQGVFLSEDIISHTNLHQSGWKRKQTELNDATTAISSFGISPNDPKALIHSLSGGNQQKVSIAKWSGFKPNLFLLDEPTKGVDIAAKQDIFQFIRNITENGSSVIYFTGEQDEALHIADRILILANGEFVGEYLPSELSPEQLLHLSEGSYSIESRS
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKHKSSIKCFKIDQISQQPETDLVFTKRSECKVKDELFSDKENSILCKQLKELDLVVSSNKEFLNEKTSDQISFLKPRETVVEKKLANGSIWPNETSHLDKSRDLSSHSNGLDALAMTPYIVKENNKTHLSPRGNYPSEAEKSCDFYGQPLHFYRENTSPCLYGSSLSNVFTEKSSDYRHGLGSPTSLVSSNTASKLHLGRKDIVKLSELRNCINSSKDSNQIQELENLLRKEKQRNTEHEKIIRRMKKELKELHSQFNFAKKLFISALSANQDILDKMNDEFN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation. Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication.
Subcellular Localization:
Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome (By similarity).
Domain:
Contains a N-terminus DWNN domain, a zinc-finger domain and a C4C4 zinc-binding RING finger domain (By similarity). The ring finger may indeed be a U-box domain (By similarity).
Sequence:
MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADSDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPVMGTTKAIDDASASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKTLVGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPVPPPRPLMQRNLQPLMRSPISRQQDPLMIPVTSSSAHSAPSISSLTSNPSALAPSVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKLLPAAALTSEHSKGASSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINAARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANISTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPTKRNVPQGETEREYFNRYREVPPPYDIKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAVGAQPRPSANREDFSPERLLPLNIRNSPFTRGRREDYAAGQSHRNRNLGGNYPEKLSTRDSHNAKDNPKSKEKESENVPGDGKGNKHKKHRKRRKGEESESFLNPELLETSRKCRESSGIDETKTDTLFVLPSRDDATPVRDEPMDAESITFKSVSDKDKREKDKPKVKSDKTKRKSDGSATAKKDNVLKPSKGPQEKVDGDREKSPRSEPPLKKAKEEATKIDSVKPSSSSQKDEKVTGTPRKAHSKSAKEHQEAKPAKDEKVKKDCSKDIKSEKPASKDEKAKKPEKNKLLDSKGEKRKRKTEEKSVDKDFESSSMKISKVEGTEIVKPSPKRKMEGDVEKLERTPEKDKIASSTTPAKKIKLNRETGKKIGNAENASTTKEPSEKLESTSSKIKQEKVKGKAKRKVAGSEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKTTQPIQSVGKPSSIIKNVTTKPSATAKYTEKESEQPEKLQKLPKEASHELMQHELRSSKGSASSEKGRAKDREHSGSEKDNPDKRKSGAQPDKESTVDRLSEQGHFKTLSQSSKETRTSEKHESVRGSSNKDFTPGRDKKVDYDSRDYSSSKRRDERGELARRKDSPPRGKESLSGQKSKLREERDLPKKGAESKKSNSSPPRDKKPHDHKAPYETKRPCEETKPVDKNSGKEREKHAAEARNGKESSGGKLPCIPNPPDPPMEKELAAGQVEKSAVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEEAVASISKDLKEKTTEKAKESLTVATASQPGADRSQSQSSPSVSPSRSHSPSGSQTRSHSSSASSAGSQDSKKKKKKKEKKKHKKHKKHKKHKKHAGADGDVEKSQKHKHKKKKAKKNKDKEKEKDDQKVRSVTV
The following text describes a protein:
Function:
Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc-112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. May be involved in thermotolerance and lifespan.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, M line. Basal cell membrane; Peripheral membrane protein. Note=Colocalizes in dense bodies and M lines with integrin pat-3. Localization to muscle attachment sites is regulated by pat-2, unc-52 and unc-112. Co-localizes with pat-3 and pat-6 at body wall muscle attachment sites.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MSLSTHYHAHKPNVPIIMEDVFGWVREGNAFQVRVWLDDHEHDLNVGDDHAFSLLHWAAKGGHVAIAEMLLSRGARVNSTNMGDDTSLHLAAAHGHRQIVVKLLSRKADVNATNEHGMTPLHYACFWGYEQIAEDLISCGAAVNVCNKKGMTPLDVCQPMCKNTILEIAQEHGQSPNDRVPFKDTTWKGTKSRTRDATLSRYTGVDVSSLNLITKIAESHSGELWRGKWQGNDIVARILNVQEVTARISRDFQTEFPALRIFAHPNICAVLAAANQPPNLVIISQYMPFGSLYNVLHEQSSVVIDHGQAVRFALDIARGMSYLHSLDPMLLRFYLSSKHVVVDEELTAKLSMADTKFSFQEVGKAYSPAWMSPEALSRAPEDLNIRAADMWSFAILLWELNTREVPFSDLPPMECGMKIALEGLRVHIPPGIARNMNRLMNICMNEDPGRRPNFDQIIPILERMIL