lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MELSTLFEYIFSCSYPRSSPQCRMKNYHCHTLLKFVQTTGTSTSSNTRMCFEPTCRPKFYISAYRNPVTTIIMNRSTAGRLIRAFHSTARARHGTAGSTSASEEEMKHFKQLAATWWDTNGPQRILHKMNLLRMDFMNENLKVLQQNTSQSAVKPAGVSLDILPDSDPRKTNAIQLTDKKRVLDIGCGGGILAEHMARLPWTSSVDGIDMSPDVLQVAVEHAKKDASLTKKLNYRRIALEDLPRDEKFDIVTMYEVLEHITYPAEFMKHALSKVNPGGWVFLSTINRTPISWFTTIFVAEHLMRLVPPGTHTYSKYINEEEIRDFFATQKDWEFVDSKGCMYVPGCGWVWTPNERMGNYMMAFRKKD
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
Sequence:
MPLSADVTKGVQRFIFILTDDYNAKTTALSAYLASYLDQKRIPFSYLKLSTTLSLTFGNLSPEKEGEAFITWDGGEVDYDVGIIERSITGELPRTSCLTLGQAIQQLYIQQAKQQETGFTRLTFEEDLLDYLVTYIQMEPTLQHPPSSGMNSYEIPIRIVEIGGGVRQPSTQIFTRTIERLLSLSCSEDPPPSAPQRGSIIILMATANPDAIKPEIMQLFCGYAPDYLIQLQNLNSTDILDDEYTINATRVDAKGMSDEKIMLKELIAKWNKAWAFKAFAAKSATELVSSMAVLPSFTDESALTAETDMKKAIEMAKCTGQMEALGNVLVEMRVDREEVVELGDEVLRGFDNALANITEEQDHAAEGIFGAICMICGTAKNTEVCPICTLNSHLLDVNEAITEATFTYLASPTDLCCKSISQKLTHMRLASNIYDEDHSEEVISDMALYDSESDTSTIADKSHLSSQKKYFGSKSVAKMVKNYGDAFLAEKDTNMPLGSLITATAKDLPSHQSYQSYQSGHSYCTDSCAHTPTAHSELQGPSESTSEVPGEIVLAHNSGSSASVRNRSTHVTLKLKKHHHPSNADGHLKLRIENLKKKEVETSLQQMLASAAQAKTLRHEMTLKHLDLPCIIAIVGKFVAREDSYLSILEALRATMHKYYHDKPFAFLWVDPTALDEKNCDDILQEAHGFVLPGGFGDIGVNGLMLSIKYARTHNKPILGLCLGFQMMVCEFARNVCGLSHANSTEMDPDTPHKLIIPISEMLETGQIKPLHKQQNAANPGTTAKYSTMRLGDLLVSVKSNTMLSECYNKYPQVKERHWHSFAVNTQYIDTLTEHGLIISGMDFTNQLPMAVELPTEAHPFFMATQYHPEFTSKHRLPHTLFVAFVSAIYRLQDM
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MERSTNETSCGSGASLTGVQFGKDLGELVKRMDVWSSQVENVLRDSTATTAFIRASAQEDVKEVMGRLTNLDAEDHFIRKVRDAQQEEIIKCEQQTNEIYRTLEDLHEHTTKLFQLKADREALISKSLSDITDKLSLRKQKVKALHEATGWYKRLLSLRCEYSDAVKFIFTNVDPRDPDRVFSFSIRLHKSTGSWTMVDCNPWVGASASFVETLNKNNELSRFVRSMRREFEVLAVRFRFLVK
The following text describes a protein:
Function:
Vital for development.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDKQPVLEPTFDSVSERENTSIEESSLLENNGFDHRNKDESLSVNTSPPLVCRKCFELGHQTENCKQKLTVNSENNSAQNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEGLLKIAQETFESS
The following text describes a protein:
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MVWFCNSADCQFSVFALTTIGWILSSTSTGLVEWRIWYMKDTSLYPPGIACVGIFRVCIYRRRTNSTTTKFCYRYSYQDTFLPFEISMAQRFLLTASIFGFFGRAFNMFALRNMSMRMFEEDTYNSFVVSGILNIAAGVFNLIAVLQNYDAVINSQGITFLPSLQMPFKPDVQEVGTAIQVAGIGVLPMLLTGMFSLFYKCPPYGQVHPGISEM
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
Sequence:
MAPSTRRVKRPDCPDKFVWLYGNPKMRDGCYEYHPAVQSHIEEAYLNDKDKCMINFHGVKRTLSFDFMSDSSGSDTRQIKRVHSTKLHMSKCKGISGASYVSTKGYQQTDEKCNICFHKQMVPTRIPACGHSFCYTCIKTNFKRRLPCPMCRGDLPTSLFVNPIRYDVDFDVECPEEFAEDCSAMFKKPDNEEVGESSSKREESKLRHYWIYEARGFWYRYDPKHEKYLEEHFLRNKPSCTLFICGVKMQVDFKKHTQKGDEWNAARERKIKRIAASDMHKFKIRGIAGVSFLVQPIS
The following text describes a protein:
Function:
Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr. Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway.
Sequence:
MSQKLPPLKIYTSQLPLVSHKNMLENEEEASHSQLFTPCPVPPSFPKASKPNSNQPYPNGPVCIYPPNIYLYAKPTMPIIQSFDVVINVAKEVLHPFRTDGRHYRDSKHNLDIQVFDHIEYVHIHWDHDTQFALELDKLVSFVAYNAMQLNKKVLINCQMGISRSACLMIAFIMKTLNLNVSDAYEYVKERSPWIGPNMSLIFQLSEYQQIIRKNSSQGPYQSSSLKQSKRKSEGNLLFPEKPHSAQLPLVSPSTSESSMFTNLRRTRSSGSISNDAS
The following text describes a protein:
Function:
Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGHTHKEYKNNEKSAIFFEWLIFFVGIIIRIIIYYYGRWQDKNFNVKFTDVDYYVFSDAAKYVLMNKSPYERYTYRYTPLLAYIMIPNFFVHFSFGKILFSFIDILVTILINQIIKIKYTNCKNYIFYTCLWFLNPLVIIISLRGNADVIPCFLIIVTIFCIYKKHIFLSSIFYGLAVNFKIYTIIYALPFMLYLNKNYLLGENIFQLNEKKKKKKNDFLLNTFFYIFRIISNFFVELFKLNYEQFLFAICSSSVFLILNCVFYIIYGYEFLYESFIYHIIRRDHRHNFSLFFYLMYLSIEKNSKIIPLITFVPQIILVALFGFKYARTNLELSMFLQTISFIALNKVCTSQYFIWCIPFLPIILCAITLSKRNMFLIISSILFFIVAKLHWLWWAYYLEFRGYNTFLQLFYSSVLFVISEISICWVFMYINFKEQKTKIT
The following text describes a protein:
Function:
V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition. Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair. Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells. Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements.
Subcellular Localization:
Cell membrane.
Sequence:
MLSLLHTSTLAVLGALCVYGAGHLEQPQISSTKTLSKTARLECVVSGITISATSVYWYRERPGEVIQFLVSISYDGTVRKESGIPSGKFEVDRIPETSTSTLTIHNVEKQDIATYYCALWEV
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MYGDLALQLVNSSHRTTLSSTPQLPLPKYALPLILSICLETRQLGTSIASIAESHGQLSLTQDRGLVCNLTVQHLAARRNKRCMLAYLATRVGGIKERWWDAGGGLAYLLSPAASASVNPEADAPDLRSALSPQELDFLRGYNNLLLDYKSDFLDVLDLTAGIEKPPGEIMVDVRVVRDAGEVFLDSGERVDFRKGQRFRLERAQVERLIIQGYLEEV
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking.
Subcellular Localization:
Cytoplasm, perinuclear region. Lysosome membrane.
Sequence:
MMDDGLETVYGTGDETGPSVMSERVQGIAASIYREFEQMIKTYDEDVVKELMPLVVNVLETLENTVTENQEHEVELELIKDDNEQLITQYEREKQLRKQSEQKFLEYEDVNDQEKRLLQARVEQMEMSGKQTGLKLKNYSDQISRHEYRENDMKLEYTALQKRHNEVVQKYMEYADRFKVMGQVDPTTQHRFRINIQKHQLVDGFDDDQLTPTKERTMSGDLSSPTTTPTNALNKYNKQSNEKNLEKELTETMTSPMAAGMGSSTTETQATVSTTNAETVMTPQTDNRHVLNPALRDIIDSTPELEGVITRPANLPVKSQGTRSATIFDELDPSVISEMDEGANIVVDPGEFSVMSPDNFYGMGKEVENILMENSELRQTKNALNVVKDDLIAQVDELTSETEMLKQEIMGLNNGKSRLNTRIADLEEDLKKAREENEKIREIDDEEDVPMAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSFEGKKNKSSIWKFFSNLFTSSSSNSSGIAAPPPKRNYPVAANVRYNAPTGYVAPNNKQRTQTIASLDNKTKAFDFLEDGEGSQRMKDKREQYKKVKAHVRKDDGRVQAYGWSLPAKHPSPSRSPASSNQSQVDGSSVVSGGGAGRGLMGVPVPVFCRPLLEKEPGTKIWCAAGVDLNGGRTRDGGSIIGASVFYSSPDPDADDSSSRSSKEGSELDKLDQDITKQQKEIDKHKKYKLSSLAWICTSNQSSTKVTVIDANQPQSILDMFPVSTAYILCIASVAGAMESDYPTDEDLPSETNDDAASASSGGSDSGFGNVNLVTASTPATPSDASPTSEPEGVVGVGDSEGSFKAEVSEANVSRNISSVTDAEKALREAVSAEPLADTVGMEGIVKDNILKTDSAASSDTEGSATDPLGATTEPIPTETIVSRQRRGTSSDLLKDGLSDSPTVSDAMHEVAEKMSSIKPTMWLGAQNGNLYVHSAVSQWRKCLHAIKLKDSIFAIVHIKGRVLAALADGTVAVFHRSEDGQWDLNNYHVLDLGRPQNSIRCMVVVLDKVWCGIRNKIHVIHPQTLKVEKSFDAHPRKESQVRLLSWQGDGVWVSIRLDSTLRLYHAHTHQHLQDVDVDPYVSKMLGTGKLGFSFVRITSVMISCNRLWVGTGNGVIISIPLSESKKPKSTGGTRPGGVIRVYTDSKTDSVRAGSTIPYCSITQAQLSFHGHRDAVKFFVSVPGNDCSPSGIATASVGSAPSPTKTDQPPPDNLTTKNMLVLSGGEGYIDFRIGDGEDEDEGSGNYGDVLTNSSRSARSERSHLIVWQIAGQTD
The following text describes a protein:
Function:
May play a role in cytochrome c biogenesis and may be required for maturation of the NrfA protein.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLYKLLSSYITLTLLFLLLAVGAAIATFIENDFGTASARALVYDHLWYEALLGVLALNLLAVIHRTKLYRFKARFLFHIAFVVILLGAGLTRYLGNEGIMHIREGESASSFLTTKPYLQVTLHEGTSPRTHFFPLEITAWKNRLQKSLPTQSTPLKIALVDSFIHKEGLGVSGYFDLELLHKEKRIKKRFTHNLASSLQKETLWLDDLQVDLAYGPQEIPLPFSLSLKAFELKRYPGSRSPSEYTSHVALVDPSQKVALEETIFMNNTLSYGGYKFFQTSYDMDEKGTILTLNQDPGKEVTYLGYALLFLGLLWNLLDPTSRFRVLLGRIKKDSLSLLLPLCLLSPLASSLYAQSDYLQGYLKEHQKGSQELSKGFGELIVQAKMGRMEPLNTLNREILYKLSGKSSFLGMSADQVVLGMLSNPRAWQGVPLIRVKTKPLQELIGIHPQNRARFNDFFDENSAYKLQKEVERASTLPPSRRGSYENDLLKVDERLNIALMVFQGSLFKLFPLPSDPHHRWLNLKESIFMLEGEEAKTLHQATALLLDSAFERQYFKGIEALQTISFYQYKKGNEVIPSESKLQAELLFNRLEIFPHLTPAYLVLGFLVLLSAFGLLFFPPLASHRVRVSFHLLGWILFALHTLGLLLRAYVSGHAPLSDTYESMLYISWSGMLGALLFFRHSLFALSASILMAGIFLFGAHLSHIDPEITNLVPVLKSFWLTLHVSVITASYGFFGVGAFLGSFALALFILKDHLKTPLDKPIHQLSQINEVSLILGLTLLVIGNFLGGIWANESWGRYWAWDPKETWSYISILLYALILHLRLLRPKHYDYLFSLLSLWGFGSILMTYFGVNFYLAGLHSYAQGDPLPIPLWVYALSLALALLSLIAYPHRHLQNSDKGNS
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MSEAEKRANGEIYRNIPRRDLLQSFMSKKQKLSVQEGEVEIELDLGLSLNGRFGVDPLANKRLLVRSPSIPDFVVNDVRSELSRTFSLPVETEELLRKRKELQSLRRLEAKRKRSEKQRNARDQKHKADKIVEEGSSGSGSSGLSELDNAPPPPVQATTNKSKETSPSSAQSLPAARNIIEDMPCVSTTGEGPNGKKIDGFLYRYMKGQEVRIVCVPR
The following text describes a protein:
Function:
Has a role in chromosome maintenance and is involved in mitotic exit. Inhibits the action of CDC14 by sequestering it in the nucleolus. Also binds to RNA polymerase I and stimulates rRNA synthesis. Influences RDNA chromatin by tethering SIR2 to rDNA in the nucleolus.
Miscellaneous:
MISCELLANEOUS: Present with 1590 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MYKLQVVLVPPSLQATMPIQFGYGPTIAESSQLLPNRTNMAQSAGDASLQYANLRSANVSFTPSYFNQSRFRKFLLFTKPTNTLLNLSDEIIDKCEKMYPSLQEDIEILSLQDNSGCDLDPDFLVKDVFNVNNIVRVILKNEIDLDDSAPVSLYKSVKRSKLNNGSPQSVQPQQQIPSSSGVLRIAKKRPPTGTTTTTTIRSATNGSMRVSTPLARQIYPPPSSKIVSNNSDDEDEDIGERSFLPPPTQPQSPPIRISSGIDAGKKIKSSIVEEDIVSRSATVDPDKTKQQRLLSGTPIMSTMTPNRVTLTGQRVVSEHAHKNELVFSASASSSSFANGGTAAVTAQDINRKPPVTTPRITSGMLKIPEPRISEIEKELKEGPSSPASILPAKAAKIPMKKPYLENGENYESDDSSSSENQETPETEPHSKASLQRSQSSIADNNGSPVKNSPLGDAMPHNVHLAELPKASNTSITKSSNGESWGKQQEHQPPRKSSLETIVEKKSQAEPSGIVEPKRMTNFLDDNQVREKEDTNDKLLEKEILPTIPHNDQPILASSDKSNGTLKSLAGKVSSNNNASKEDGTIINGTIEDDGNDNDEVDTTVRIVPQDSDSSSFPKSDLFKMIEGDDTDLPQWFKGKNSRTSGNSKNSKPYTTVLNKDIDNSKPDPRNILPQRTPRSAAKRAAQLLAGAKKNEVPQKSTEDSSSAASTDDESESGIETDFSSDDDFKRKNMSVPNNGPKDISLHSLKGSVVPVKDSKIINKEVDEERNDKRDSQKKSAVSESSVTNSKISEQMAKSFYPNSNKKQNEATKVETKPATQASSFPVVGGSPSVATKGTTSFNEEGNRKNVKTKAKNESAQIDRQQKETTSRVADLKSANIGGEDLNKKAEGSKEPEKASANIQDANDKNNSKEKEDSKSKQVSQKKLKMTDHLKEGNVQLPKPSANDKLKDLKAKFTNSKTLVPPGIISNEKNNSSANDDDSSSSGSSTEDESSSSSSSSDEETSTSRKARRVVVNTPREPVRSSSKIEAPSPSVNKKINATPDKIPVTQLMDMSSPPSVKSKTTSNPSSILHDLPRKVRPSLSSLSDLVSRGIPDVKEKTSKSNEKSQTKAPSSSDDESSSDSDSNSSSDSVSDSSSDSKSESDSDDSGDSSDDGKSFISAKSASAALGKKKKPSGGFASLIKDFKKK
The following text describes a protein:
Function:
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C). Necessary for ensuring proper chromosome segregation. Can regulate chromosome segregation in a kinetochore-independent manner. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase (By similarity).
Domain:
BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.
Sequence:
MTIGYRDAAGDPLFPWLMEIKNSMEDLYAGKNSGYDLDKLLFDCISTYKKDSRYRNDLRFLKIWFLYLEGREDFERVYREIEETEICKGHSLLYEWYAIFLEVKGLWRRANSVYQTGLSRKAEPFDRLKEAHSLFLQRISKRTKASSLEKVGDDAQATDLETGFVNPWETSTVNGLIHKIKPQLVKYDGYHVSNKVFPGKANLSSLQNYSRNKIIEIGGRKYQMKGCAGQGGFAQVFKAFIDSNPDEVVALKVQKPPFPWEFHMYRQLDCRIPDSQRSSFGLAQRVHVYSDYSILVCDYLSHGTLQDVINSYVVVGKSMEEVLCMYYTIEMLNMLETLHSVGIIHGDFKPDNLLIRYPPENLTETGFHEKTGSWSKKGLCLVDWGRGIDLSLFPRTTEFTGDCRTSGFRCVEMKEDKPWKFQVDTYGLCVIVHMMLHNVYMEIEKKQSLDGGYINMPRTSFKRYWKVDLWKELFTKLLNRETCEDDTETLRNLRKSMEEYICSDPKLMKKLNELLAKQRISLCSS
The following text describes a protein:
Function:
Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus. Early endosome.
Sequence:
MSEVLPADSGVDTLAVFMASSGTTDVTNRNSPATPPNTLNLRSSHNELLNAEIKHTETKNSTPPKCRKKYALTNIQAAMGLSDPAAQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNKNLSPTAVINITSEKLEGKEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRGNHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKDHPKTGAKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVSDIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEKQPWSDFAVLNGGKINSDIWKDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALACSSLQERANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTVISEKNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQKVRPPPPPADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in the postembryonic regulation of body size, mainly through control of cell growth. In particular, controls the volume of intestine, muscles and hypodermis. In addition, regulates growth, intestinal granule distribution, lifespan and number of offspring.
Sequence:
MVFADFLEKIKSLFAKTKDPITSMSPPQENRSPKAEYLNNFFNTNPTNGKSRGSQEAPRKPLGQTNLNVQGSMPAKKEGFNRVLDGLKKRQLQHDFKLERAAETYEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGPLGIDVFLVMDLMQNNLHHIIYGNEDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVDMWAVGCIFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQKRINIQDALLHPYIQRVIPAEAPQKKCPFRVKKDMMQVEDLNHQELISMMKQDVRSAENPITYSELHSGDSTGSTSDMSTNTSGEYSPIAQHEQLLEDVATQISICEPTCDL
The following text describes a protein:
Function:
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Sequence:
MIQQQSRLSVADNTGARELLCIRVLGSTVGSKGLTKGGGNRRYAFVGDIVVAVVKDAAPNMGVKKSEVVRAVVVRTRQAIRRDNGMVIRFDDNAAVIIDKNGNPRGTRVFGPVARELREKNFTKIISLAPEVL
The following text describes a protein:
Function:
Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MSQKTLFTKSALAVAVALISTQAWSAGFQLNEFSSSGLGRAYSGEGAIADDAGNVSRNPALITMFDRPTFSAGAVYIDPDVNISGTSPSGRSLKADNIAPTAWVPNMHFVAPINDQFGWGASITSNYGLATEFNDTYAGGSVGGTTDLETMNLNLSGAYRLNNAWSFGLGFNAVYARAKIERFAGDLGQLVAGQIMQSPAGQTQQGQALAATANGIDSNTKIAHLNGNQWGFGWNAGILYELDKNNRYALTYRSEVKIDFKGNYSSDLNRAFNNYGLPIPTATGGATQSGYLTLNLPEMWEVSGYNRVDPQWAIHYSLAYTSWSQFQQLKATSTSGDTLFQKHEGFKDAYRIALGTTYYYDDNWTFRTGIAFDDSPVPAQNRSISIPDQDRFWLSAGTTYAFNKDASVDVGVSYMHGQSVKINEGPYQFESEGKAWLFGTNFNYAF
The following text describes a protein:
Function:
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
Sequence:
MSLGFIQLGQCGNQIGHALFDFMIQETQMSSPGAQALLNEIFFFERKNKQIAKSLLIDMEPKVVERCLKAEYYDKAFSLTKQEGSGNNWAYGFNNHGPANKNAILQIMDTLLEECGYLESLFFISSLAGGTGSGLGSYILELMADRYPEIELFNICVMPHLTGEVILQSLNTVLTIGSIYQHSEGIILLQNDEAQALCNNLLNLKSPSLNDINQVMSTNLASFFWPCLTNQVYSTFHNNLQYVQELLNITNNQYKLLQLNQIPQLPQQSKAFQNDTWSALEKRIQQMVLTGTKEYNINWHKKGQQPFKQLMIARGNDVKKHQFNWNTVQDEHQFNKNEKSITVVHNSSNIVESLNQISDRANQMIQERAYLYQYEKFGVKIQHFQESMGVVEGIINDYEQLIQ
The following text describes a protein:
Function:
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQLTTAPVLSTPEVHIFEDPTPSVKKDDLPKLSDEDLFDVYEISRTVKEIREGGWKKIALQFSDGMLSDAPRVFQELENRLRNLPVEPASNEIPETGNSSLETDFSNPSASIATSSIRHKLYILADTSYGSCCVDEIAAEHVDAQVVIHYGRACLSPTARLPVIYVFTSRPLNLESVVQAFENTYKEKDDKIVIMADITYHSHISSLVSLLQDGGYKNLLAPEITHDPSAIIPNRKLDEGVDMKEHSLFHISEPPSALLLTLSGRVKDMHIYSTDSTTGNETTKTNAARALMRRYALLTSLSSCAVFGILINTLSVTNYLPTVNSLAALIRSKRKKSYTFVVGKVNAAKLANFSEIEGWVVVGCWESSLVEGEALFKPVITPFELELALQSDDERVWGGDWVADFNALNLQASTTAVPSAEHTESNAVEESENVNATEDAEDSEEESMPPEFDLRTGRYVSHSRPMRSSQATSPEPKKMLENGLQPNASNKLVKRAKMELATVNGEASPGAEYLREKRTWTGLGSDFDKEAIEEGREREVAAVVEEGRSGVARGYTVGEDASRS
The following text describes a protein:
Function:
Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex (By similarity).
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAMKTSGSTIKIVKVKKE
The following text describes a protein:
Function:
Serine protease inhibitor.
Subcellular Localization:
Secreted.
Sequence:
LFVGLTSAKYHDVCQLPRDPGPCRAYIPLYYFNSRTCLCEKFVYGGCQGNANRFDTVEDCRRRCGGGDLCSLPRDSGPCEAAIPRWWYNKRTNRCQRFTYGGCEGNANNFKTLDECRFQCRKRSTY
The following text describes a protein:
Function:
Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Also functions as a pH-independent carnitine efflux transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEHKKSPDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKKIAPEDLPDKYSIYNEKGKNLEENINILDKSYSSEEKCRITLANGDWKQDSLLHKNPTVTHTKEPETYKKKVAEQTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYEIAFYFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAPTTFLYKVASNV
The following text describes a protein:
Function:
May glycosylate diterpenes or flavonols in leaves.
Sequence:
MMKPKVIMVPYPAQGHVTPMLNLASALTHLGLSPVVVTPEFIHHMIAQKTHVTCMPIPDGLDEDVPRDFFAIEFAMENNMSVHLDRLVRQLNGCDGDGVAFMIVDLLASWAFKVGDDCGVPVVGYWPVMFAAYQLIAAIPEMLSLGIISETGIPQNEGPVYLGYDQPPLSTRDLPWLIGSLASRRSRFRFWTRTLARTRTLSQILVNSFPEEHRVDTNLQNYQSKQHPNITPIGPMIQHTKHENLRFSEDDKSCLDWLDQQSEKSVVYISFGTWVSPISKTKVRNLAMALESSKHSFIWVLGSKWRDGLPKGYVERMLDRGRVVSWAPQSEVLRHKAVGCYLTHCGWNSTIEAIQNKVKLLCYPIAGDQFVNCDYIVKIWRIGIVLEDFGEEDVHRSLKRVMEDIEMEERLVKMNERVYGMETSLRVYSNLTKFVDDYVMVE
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MENNGKSRGTQLVGQIDDLTRELQDAQKVVVSRINERNRLVSDMMERYRSNLRILQEQRVTVLSELDRYKEEESRMKEALQNLNSTKEEFKREMDAYQLKAEKMRLQKQQLQKQLDDLNKMFADRANEIQKYKEMVTRQRQLDSPEIKLYEKLLGLQIDKADTHMLKFTFTDFGREREYKSVIVDVSQLNDDSSPLRIKEIESGVSASTVNELETVLNQQGIVQFLIEVRKVLVKSE