lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium.
Sequence:
MSPKGVGHSKVEESAVQVAVRVRPLLPKEILHSHESCITSDPEERRVTLGNDRHFHCDFVFEDGSTQEEVYTNCVQPLIEAFFHGFNATVSAYGQTGSGKTYTIGEASISAFRDDEQGIIPRAVAEIFKLLDENDLIDFSVRVSYMEVYKEVFRDLLEVETASKDIHIREDERGNVVLCGVKECEVEGLDEVLSLLESGKTARHTGATQMNPHSSRSHTIFTVLMEQRRGGSRAANGSVQILSSKFHFVDLAGSERILKTGNTGERLKESIQINSGLLVLGNVIGALGDPKRKGTHIPYRDSKITRILKDSLGGNAKTLMIACISPSSSDFDESLNTLNYAKRARNIQNRATVNCRGEPDRIEGLELQIKALRRALENRQRSETRIIARSDPEKRLRPFEVDVRKLQAESAHYRTCTDSAYRLLTELQGEGTLNAGQILRVKEWLCGVEEERSGLTSASGLDSGIESSSTEDSTALKRRQAVLNNQDLVKEDWRGEREDYTSQLQAQIQQLEQENTDFLVALEDAMEQYKQQSDKLQEQQDLIAELHSLLAQPGGAGFLHLKQRPHTAPINSLLQTPDRLTPPCDSDVGRSLARQLDVGASVDSSSYSEQTQWDGTHGNTHCESSRKLNRDEDGHMQTTRDKRKSINVTWTKKDIAIPQGPFGGTRTALPQTLGLCHPLGMQFNRRTSNSSIGESSVWESVRGFGGEFCSDRGLLQAQQKIRELSITIRMKEELIKELVKTGKDAQAMNRQYSRKISELEAEAEQARVELTEAQKQLQELEVQGGRDAVDRSKAQECRRKIAAAQSKVQVLKQKQRDTAQLASLSAQSERRVQELERNVQNMKQQQDLLQRRLREESQQKRRLETEMQKGKHRVKELEIKNEQQQKILRIKTEEIAAFQRQRRSGSNGSVVSLEEQQKIEEQKRWLDEEMEKVLDQRRGLEDLEGELTKREEILAKKEALLWERSGLESKKLRSSQALSQDLLTLSSRIESLERELTERNGLLRSGSAQDSQQIRQEISNLRQEKELLLKQRVELDDKLRQGNLLSPEEERTLFQLDEAIEALDAAIEYKNEAITQRQRQLRASGSMLTQWEMNLMAKLTYLSASETRALLCKYFDKVVSLREEERRLQMALAELELRVEEQQNLVGWLEAALERQQLEADRRLTQQQKEHERNIQLLLQQCREQMDEGLAGRLRQYEGLIHNLSKELNFCKIANQELNIKLREMCGPVNLTGEQCKGLNCDSLLLAGAQSRVAEDVKPIIDAERVQKSREEMREPVNAPLPATWRRSSLPTEDQYTMEELRQRAACELPNNRIVQPGMNSTHWSGSTSLPVTRPRREPRRSSLNTAPLYSSSAIIDVRRNPV
The following text describes a protein:
Function:
In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets.
Sequence:
MNVITPPFADGVDPKPVCIVADDIFETMTARRKIHFSIYVIFKKNVELAEPFKLLYYTEKKNVAHLDGSVAQDFGLPMWTKDDGQRAPDLSRQKNDYIKLDFFTNINNPEDGFSYCWTDCISTKNTTMVPRQLMPPSKRSMKLYLILPVEESNIMVLSEKAYGSLQLMKKHRKMGQPPQRVGCYINFNCQTSKVMFGCGHVYCEQCLNSWNDKPCSVCLKPVTSEPTQLKLRQGPCPFDLCSPNSSTMGIVLIPCGCHVMCQNLEDAYERNKHHLEPLIEKIKYCPFEPCRIRVRKLKKPFWHQQDKEHTLEMNSA
The following text describes a protein:
Function:
Architectural component of nuclear structure that plays different roles in controlling nuclear size and morphology.
Subcellular Localization:
Nucleus matrix. Nucleus lamina. Note=Forms aggregated foci in the inner nuclear matrix region. Localizes in the nuclear periphery.
Sequence:
MFTPQGKGWTGWSTPAPANQRSGGGAPAASAPLGKGKGTTLRVAELEQELHEYQYNMGLLLIEKKEWTAKLDEINQALTQKEEILKREQAAHLNAISEYERREESMRKALGVEKQCVTDLEKALREIRGEIAEVKFMSEKKITDAQSLEASLEEKRLEIEGKLHAADAKLAEANRKKSQADRDLEEVEARQRRLEKEKLYFENERKAGEDRIKRQEDSLRDWDKKLKESQNRILDLQRSLNDREERANENDKLFKIKQEELEEAKKALEHTKATLKIKEDDINKRLAELHLQEKEAESKNRKLEEREKKIAEREEKVSAREKVGLQKLLEDHNVKLESKRRDFDLQLENEKKSFDAMLVQKEADLVQREKDVRSSEEKLSKKEQVLNESKKKLEEWQNDLDTKSNALKKWEESLQNDEKQLSEQKLQIENERKQAEMYKLELESLKATVVAEKEKILQEQNNLKLTEEERQEHIMLTAQLKKEIDEYRMRSNSLSEETEDLRKQRQKFEEEWEQLDEKRTHLEEEAKKLNNEKKNLERWHDNEEKRLKDREDELDIKYKEQGENLALKEKSLIDNIDHQRLENEELLKRERADLQRNLQLHRHELEMEMEKKQASKERELEEKENELNRKMDFVENELKRAAELNESKIQKILLEKKQLQKEKEVLVEDRQKLETDKADIRRDIDSLNTLSKSLKERREAYNRDRNNLIDIFEKYKVCKNCGVIIFEGLDALALKDSTDIEYPSLAVEADDRSPNPDTLAQETGALVNSGGRLSLLQKCSRIFKFSPRKKAEQSSEQQAVKNTDFGARLEEASQSDDDYEPTPVYQVAYNSFDAEDLPSESGAFENEESERQDIADDVQMESSLGVADNCVDIHGTQSFDGNTDMVVDTTIVDVDQNGKDSAVLPVVDLEPETSKQGRRQQNRKGRAKGGVKRTRSVLAVVEDAKEILGENLEVKKDDGQGDSVTVGGTRKRRFAGATISEQDEDSEAHSESVSLGGQRRKRRQTAAAVTQAPGEKRYNLRRTTVANAATAAQTNKKKAAKKGSKQTVEATADDTEGTSKAEEPATGSKGASQSADDASQLPEYSQAEAGDTHGPVEVTSAEGVDIVDGIDAAPDAMPMTPSGSELGAEQDDEEDDDSERRNQSIGKKLWSFFTT
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Subcellular Localization:
Nucleus.
Sequence:
PSAPIVVRAIRPTMKMIEGVLFGMGNPLLDISATVGKGYLEKYNLKANDAILAEDKHLPMYEEIVKMFAVDYIAGGATQNSIKVAQWMLGKPLSTTFVGCIGQDNFGDILKEKAEEVGVRTAYYRQSEIPTGLCAALLCGTDRSLCANLAAANNYKVSHLQEKDNWALVEQASYYYIAGFFLTVSPESIMLVAKHAAQNGKTFMMNLSAPFLSQFFTKPMMEAMPYVDILFGNETEAQAFADKHEFNTKDIGEIAKRIAGLPKVNSTKPRMVVITQGCQSTLIATGPHELTEHQIIPLDTSKIVDTNGAGDAFVGGFLALLVKGKPVKECVQAGHFAANLIIQRSGCTFPKECTYE
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Sequence:
MILFDKNKRILKKYAKMVSKINQIESDLRSKKNSELIRLSMVLKEKVNSFEDADEHLFEAFALVREAARRTLGMRPFDVQVMGGIALHEGKVAEMKTGEGKTLAATMPIYLNALIGKGVHLVTVNDYLARRDALWMGPVYLFLGLRVGVINSLGKSYEVVWKNPDLARKAIEENWSVWPDGFNGEVLKEESMNKEAVEAFQVELKEITRKEAYLCDVTYGTNNEFGFDYLRDNLVLDYNDKVQRGHFYAIVDEADSVLIDEARTPLIISGPSKESPSVYRRFAQIAKKFVKDKDFTVDEKARTIILTEEGVAKAEKIIGVENLYDPGNVSLLYHLINALKALHLFKKDVDYVVMNGEVIIVDEFTGRLLPGRRYSGGLHQAIEAKEGVPIKEESITYATITFQNYFRMYEKLAGMTGTAKTEESEFVQVYGMEVVVIPTHKPMIRKDHDDLVFRTQKEKYEKIVEEIEKRYKKGQPVLVGTTSIEKSELLSSMLKKKGIPHQVLNAKYHEKEAEIVAKAGQKGMVTIATNMAGRGTDIKLGPGVAELGGLCIIGTERHESRRIDNQLRGRAGRQGDPGESIFFLSLEDDLLRIFGSEQIGKVMNILKIEEGQPIQHPMLSKLIENIQKKVEGINFSIRKTLMEMDDVLDKQRRAVYSLRDQILLEKDYDEYLKDIFEDVVSTRVEEFCSGKNWDIESLKNSLSFFPAGLFDLDEKQFSSSEELHDYLFNRLWEEYQRKKQEIGEDYRKVIRFLMLRIIDDHWRRYLEEVEHVKEAVQLRSYGQKDPIVEFKKETYYMFDEMMRRINDTIANYVLRVVKVSEKDEKEAKEELGKIRLVHEEFNLVNRAMRRATEKKKKKDGLHSFGRIRVKR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MATVKIVINKIRQSKNREGAESGAMPVKWLLHWKNISNLDKKMAEDILSEMLKSIERMYAVKEGPWKNTLSFFHPNLKDLKKPTVCASECLGLSLYEDPEKFFFVLFPPKLVVEVDSNYSLLMNHLGSYKKGNFIHFEGTRYRCGDFRLRLGFASSVSLRIKAVFMEIEYLPISSIKTAEPIMEGFISLLKLLMSQTGIPGNFVCHDPKYAEFELPDQYSSMHTALQYSYLMTQLI
The following text describes a protein:
Function:
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSPDLLLPNEPSLSVDENVAIDWQPITLTLVEYPKGDFVGKLLAWISLAPLGIGAGFVALILFRRDLHTIVFFLGTLVNECLNILLKHWIQEPRPVSRAQIWTEYGMPSSHSQFMCFFATYVLLFIFIRLHHINNSNSARFERLVRLLVLAICWTAAFLVCFGRIYLLYHTLSQVLIGALVGTVMGALWFLLTHFVLTPYFPMVVLWRVSELFLLRDTTLIPNILWFEYTVTRHEARARSRKLVSMKSQ
The following text describes a protein:
Function:
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
Sequence:
ASEECEGIWDKPGCCMVEKPELNKRSRIDWAVVGEPMNFVHLIHIGPGDMRAGDGLATTGASQGQLRPRELKPWTLSDLR
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MSGTRTSSQQILKEFASVVTEFQRSLIAGTDNQDPLQLVQEFRSIAGEAALVCAEETEDQRDRTQFVNFELEAKLWYLVELLVSFRTSDAPMDDIELHDYNSNAVFKKAQLQEDPELYVVWLIIAWIQENLTVSPRPAELPTTKWSNTLLAGGLKSSDLDCPLREEGVQIHPKDNQDDHCFYKYMYELILAGKYEEVRRECEYSDNLTLGMIMCGLEDYVDPRIDLELAGDYEGHQGIKKRALWRRAVYALSRNPNLDKYEAAIYAFLSGTIPQDIDEQQLDWERMLLVYLNQIWNIKIENYLLEKERINKEELIEQMPSQPLSLSAVLNIVASKHVEESEHPIRVLMGAVILNTISPAVKSFIDMLLDAVKGVDQENDLLSEPYILRILTHLVIFLDKACPGVIEEGDKSKLVTTYVSLLNLYEQYDLVPVYISCLDEQDIMEAYSFFLSNLVGDSSRERQLELCYFFQLPTANILKRTAQRIFNDTEPHYNLADTVTMNSEVTDIDLHLISAVDWLMKGRLHVDAVESIIALCRRFLANGKVNSLSTFFEQHNMDDLIKNYELDQLSAKEEYPEDRFVQEIGQYTKLITGFRQYKNWENSSHTVSSSKNTSALLQQFQAFASTLRGLVTEFLVELTEHTDMPSEDRDMLYNIRSLYTPYLLIELHNSYTSTAEKLGVPSFLQEAVNLSTMVANETDKIYLLFQNSGKLKEYLHLVAKAVALIGH
The following text describes a protein:
Function:
Acts as a magnesium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MKIKVEIDLQELIEKGDFKTLKRVLEQQDPADVKEMIEKLPPDLKVVVFRLLPKDKAAEVFSELEPDDQLELIKLFREERLKEIFESMDPDDRVELLEEMPANVVKKLLSYLPPQEREELLYILNYPEDSAARLATTEYVELFEDMTVREALEKVRKEGKKKENIYSLMVIDRTRKLKGTVELRDLIVADPDQKVSEIMNKDPVFVHAIDDQELAAELMKKYDLIILPVVDSEERLIGVITFDDLVDVIEEEATEDIQKMASMSATYTSYFHTPAWKLILKRSPWLVVLLLLESVNGNIISSYEKFLASIPIIAAFIPTMIGSAGNTGAQISALMIRGFTLNEISLKDWWKVLLRESLIGSTLGLILAGVLYLRAFLISSDPTLNFAVATALLVLILYANIMGALLPFIARIFKIDPAFMAGPLLTTIVDVTGIMIYFYVVHSFLS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus. Plastid, apicoplast.
Sequence:
MKDIIKIKAKRKNVNKINEENEEEIYQLKENNRAQNDDDDDDYNNNEKNKINKIILKDENINSKNDYNNMMNPYNVIGKSGNEEDTHIKIEEEKNKDNLYECKNDDNKFYESKINFIKKQDEANNEDNNNNNNNNNNNCYYNNYENKHLNIFNNKNEVNNKNLSSNKILKDEYYDKNFNEDNINNLKEFIHNENKKPKTGKLYNNMNILNDEENFSGLVIKNKEHNKKIYENSKCVNTLNEKWKLLPAYLKVKGLVKQHIESYNYFIKREIKTIMNATTNKIIKSDIDEHFYVEFLDITVGTPSVEENMIETKLTPQICRQRDLTYSAPIYVDVEYVKGNSIITKNNVEIGRLPVMLRSDICVLNNKSEEELMKLGECPYDPGGYFIVKGTERVLLMQEQLSKNRIIVEMDIKHNICATITSTTAESKSRCAIVYKNNKLYLKHNSFIEDIGVCIILRAMGYESDQEIFQMIGSHKNYVNGILLSLYELYNENIKTNLDALLYIGKKIRPRLLAKGFFSSMKEKQVKNEKDIIEEGLDFLSRVLLSHIQQKSKYDFRNKARCICLMIRRVLDSANNKNEIDDKDYYGNKRLELAGQLISLLFEDLYKRFYFTLKKQIDQTLSKYMQSNYNSKLRSTGNNMNDNYPDVFRNLPKDIITRGMQTAISTGNWNIKRFKMEKSGVSQVLSRLSFIACIGMMTRLNSQFEKGRKVSGPRALQPSQWGVLCPCDTPEGESCGLVKNLALMTHVTNDNENNENLIEILYTLGVEDSDSLTGEEIYKEGVFFVILNGILLGVHKRPQKFMQRIRYLRRYGKIGQFVSIYDNFLHNAIYISTDGGRLCRPLIIIENGKSKLLPQHIKALENGTINFFDLLKSSVIEWIDVNEQNNLLIALNESDISLSTTHLEIDPLTILGVVAGLIPYPNHNQSPRNTYQCAMGKQAIGAIGYNQFVRCDTLLYLLVYPQKPLVKSKTIEFINFEKLPAGQNAIVAVMSFCGYDIEDAIVMNKSSIDRGFGRCMSLRKHSVELKKYFNGSNDIVLPSPLVINKLQQQRKEREIKSEIKNEKEKDGIKQEHHHNNIDSKNNKSSYNNNVSKIDNVKKDSYGHKNISNESKDDIKKMANKDIRKYHSLDMDGVASIGYLIKEGQLYVNKFSPKNIKDHVKDIGKVDINDFKINEIKYKSVYPSYIDKIIFTENSEGLKLYKIIMRQTRLPELGDKFSSRHGQKGVVGLLVNQEDMPFTESGICPDLIMNPHGFPSRMTVGKLLELVASKAAVMDGEYKYGSIFSGTPFEEIAEILFRYGFNCSSKELLYSGLTGEPLETYIFMGPIYYQKLKHMVQDKIHARARGPRQLLTRQPTEGRSKEGGLRLGEMERDCLIAYGVSNLLLERLMLSSDVCNVYICEDCGMMGYDLYCTFCKKCDKNIVIQMPYACKLLFQELQTMNVFPKIIVKEV
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRPTEPWSPSAGTAPWDYYSGSGAPDELEPEELCAARDLPYSHAYIPALYLAAFAVGLPGNAFVLWLLSGARGRRRLVDTFVQHLAAADLGFVLTLPLWAAAAARGGRWPFGEGLCKLSSFALAGTRCAGALLLAGLSVDRYLAVGRPLAARSPRSRRCALAACAGVWAAALAAGLPSLAFRRLRPLPGQDRGSQCGEESSDAFQGLSLLLLLLTLVLPLAVTVVCYCRVSRRLRGPPHLGRARSRSLRIILAVEGAFVGSWLPFCALRAVFHLASLGALPLPCRLLLALRWGLTVATCLAFVNSCANPLIYLLLDRSFRAQLRQRGACGRADRPARGSSSASSLSGEDGSPFRSPARAGGRAQTASAPSAVGP
The following text describes a protein:
Function:
Probable ATP-dependent zinc metallopeptidase.
Sequence:
MHTTSFLPNSLLTCRSCFFPILPKAPHIGFIPIRSFSDQDKDQDKNHQSFPLRLLQFSTTLTIVSTSLSISSVVPVALSASNISEKKRTLSRKRETLSPQELKSWCRDLPTINERIPYTDVLRLKEDGKLKYIVKLQSSDLKYRPDPVLVVLDDSRVFRTTFPSVNRDERFWSEWERLELNSVCINAYTPPVKPPQLPMPLLGFLIKWMPSWMISLVNDIPNSLLKRSMEERSLKRGIIDEKKGVDSAIQAENKLKDKLKRMEMRRLRKVEYQQSIEETKMKYRKMDLFWKKIANDSFIINTIGIIFFYLFYRVVVLNYRKQKKDYEDRLKIEESEREEKKKIKILEREMAGLGPGDGMDEVEDGEGGTEENPYLKMAANFMQSGARVRRARGKKQDQFMDSFDDVKFTDIAGLGKIRVELEEVVKFFTHGDMYRRRGVKIPGGILLCGPPGVGKTLLAKAVAGEAGVNFFSISASQFVEIYVGVGASRVRALYQEAKDNAPSVVFIDELDAVGRERGLIQGSGGQERDATLNQLLVSLDGFEGSGDVITIAATNRPDILDPALVRPGRFDRKIYIPKPGVLGRHEILQVHARKKSLAKDIDFTAVASMTDGMVGAELANIIEVAAINMMRDGRSEVNTDDLLQAAQFEERGHLDKKERSLDMWKQLALNEAAMAVLAVNFPDMNNIEFITISPRSGQELGYVRVKMDSMKFDEGMLSRQSLLDHITVQLAPRAADEIWYGEDKPSTISAETTDNARSAARSFVLGGFSENYHGISKFWVTDRLNDIDLEALRILNICYNRSKEILIRNRILVDVLVDKLVNKKSLAKQEFFQLVEEYGHLESLPPSIVDIRRNRQAELQEIKG
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MMEFSSSSKRAKTPAASNNISVSCLVDGCNADLGQCREYHRRHKVCELHSKSPKVTIAGREQRFCQQCSRFHSLAEFDEGKRSCRKRLDGHNRRRRKPQSDSISKTTATFLSSQPGMSRILSFNSTQIHLSSVVGSARTTGIRPDNHTIGPFNNQPPLNYLTRSLPTPSPHNGVGGDNHFNFFQHRSLPLPVSSSQLNRGAGHSRALSLLSSSPPAHQTPAIMPPISSGISQYGFAQLEMHNETMLTESSGTTLQFQGMFNDDHGDSSSSGIKQQTLSFRWD
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate. Is also able to convert 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP but with less efficiency.
Subcellular Localization:
Cytoplasm.
Sequence:
MQTSLFEFANVLITAVKEASYSISKFKEEVEIKYKSDGSEVTQVDTQSQQIIFSIIKNKYPTINIIGEEDVENGIPDNQLPTITQLSFGSLENKIININDIIIYVDPLDGTDCYTHKQYDSVCVLVGVTYKGKPMIGIVSKPFYNNEITFAIENYISSISLQPLNDKIIFVCSKKNDIQHLIKSFPDPYEVKYKGGSGAKMMAIIHQEADIYYHPLIQSCTWDTLAAQVILEAQGGIVCDIYGNPLCYPSSKKESMRHKKGVLCLSPRAKKYLPYMLSISKTILL
The following text describes a protein:
Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular Localization:
Secreted.
Sequence:
MLPLCLVAGLLLATVPGLCQGDEAIHCPPCSEEKLARCQPPTGCEELVREPGCGCCATCALSKGMPCGVYTARCGSGLRCYPPRGVEKPLHTLMHGQGECMELADIEAIQESLQTTEKEESEHPNNSFSPCSSHDRKCMQKHSAKIRVVSSNSGKMKSIGSSAHREDTRPMAQGSCQSELHRALERLGASQGRTHEDLYMIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVRLSGGLELRGELDCHQASDSLRD
The following text describes a protein:
Function:
LEA proteins are late embryonic proteins abundant in higher plant seed embryos. The function of those proteins is not known.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMFGFGLLKQYAGTTEQISTAAEALVGRSTTLTEALKAAAINVGRKPVETTDLAAIKEVEARAIGGDIESDGGVTAVASKAVARNQKIGEDNEKTNLGDVIAEIDVKVTRDREVTSEDAEAVIRAELNHSPFNNIIPGGVAESVTAAYKLNCNPCNVSL
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MFPRWIRRGESDLVTARNKTHGKDSEIPSACFGKTMLQVLLVVFWGLLVLHLVSLTSTLSIRQLVVSSSLAVRGITADEVDNIQPQTNEAVGGLTEDLVPPREADKTLGGLTEEFVAQGEADNTLGGLLLSPELFEDSRCISRSREYQLRKPSTFKPSPYLISKLRDYERRHLKCAHEAKKFSPQTNATEQDFGGCRFIVWMAISGLGNRIMTLTSAFVYALLTNRVLIVDRGLGTDELFCEPFPSTSWLLPESFPNEWMNNLGSNSTSKFGFLARNFTFTSSHNGYSYIDIMHSSDKDDTKFFCANCPSYLSSFPWLFMRSNQYFLPGLHLVPEFHDELDKMFPERQTVFHHIVRYLMHPSDAVWGLISSFYETHLANSQHKVGLQIRVLSDDPALLEVFPDLVLKCAQEKKLLPDVALNTNNSAVGNQISNSVSVLVASLRVVFYNRIRELYLNHPTTDGQQVGVYTASHDEVQFLNFLSHDMKALADMYLLSFSDTLVTTSWSTFGYVAQGISGVNPWILTKFDTTDTVPEYIKNYGICNRGISIDPCFHNTPQMDCENRGWTTDPGKMLPYIQHCEDVPWGIKIMDPATGGH
The following text describes a protein:
Function:
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch endocytosis.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein.
Sequence:
MNRLFGRGKPKEPGPSLNDCIAGVDARATNIEEKISNLEAELRKYREQMSKMREGPAKNSVKQKALRVLKQKKAYEQQAESLRNQSFNMEQANYAAQSLKDTQATVAAMKDGVKQMKTEYKKINIDQIEDIQDDMADMFEQADEVQEALGRTYGMPEVDDDDLQAELDALGDEIALDDDTSYLDDVVKAPEAPSREPGADSIVPGKSTIETDEFGLPKIPTSLKTT
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Subcellular Localization:
Mitochondrion.
Sequence:
MRLSSLLRQKSTVNAIDLGQISYGAALKEQQKYVDLVKANKSETHSLNFILALEHTPVYTVGIRSKGYTKEEETRLMRLGAEFHRTSRGGLITFHGPGQLVLYPICDVRRISIKQLGVRHFVDKLEQTIIDAATEGFGIKNVGRTANTGVWVSNERKLAAIGIAVSGGVSYHGIAINCNTDLRWFDNIVGCGIEGVSTTSLSQETSRNVTVSDARPILLNAFANNFECLLNEPNDYSTCSNLKITNVVSS
The following text describes a protein:
Function:
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MATSMAREFPRLAFLCNFRVVSPCLGSSTTSIFSRTQNDTCMQVARYRAPPFPLDRSRYIPDKSDPKTPEFQKTLKFDRKLWGRHGEASGFDPSICWPTKAELAEMQEEERDWCLTLQEMQQNIAIRRAEEEKARIAREKRIAANMAKMPKLIEQVHEERRLKKEQLEEAKKRKEHLIAKARERLGYNVHPNSPKFEAMLEEIENEERKQKKKAKKAKQEAMREAFKAALATAEAAKIQDGATINTDIPLKAHKTQND
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHPEIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKRSLFTGNGPCEMHSVQKNEHDKTPEHSRKRSRPSLLRPVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFAQFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKELDHWTLLQGSWTDDYCMSKFKNTCWIPGYSAGVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPVEVQHLARYVEQYVGTEGASSSPTEGFLLKPVFLQRNLKKFRRRWQSEQARALRGEARSSWKRLVGVESACDVDCRFKLSTHKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHQHFEEWHSRWLEDNVTVEAASLVQDWLMGEEDEDMVPCKTLCETVHVHGLPVTRYRVQYSRRPASP
The following text describes a protein:
Function:
Probably part of the binding-protein-dependent transport system YcjNOP. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNRLFSGRSDMPFALLLLAPSLLLLGGLVAWPMVSNIEISFLRLPLNPNIESTFVGVSNYVRILSDPGFWHSLWMTVWYTALVVAGSTVLGLAVAMFFNREFRLRKTARSLVILSYVTPSISLVFAWKYMFNNGYGIVNYLGVDLLHLYEQAPLWFDNPGSSFVLVVLFAIWRYFPYAFISFLAILQTIDKSLYEAAEMDGANAWQRFRIVTLPAIMPVLATVVTLRTIWMFYMFADVYLLTTKVDILGVYLYKTAFAFNDLGKAAAISVVLFIIIFAVILLTRKRVNLNGNK
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The coiled-coil domain is required for assembly into the NuA4 complex.
Sequence:
MAPNTRVSKCQISRPILVGNDAKPLTKEEKEKAPTDHTHTWRIFVEGVDGEDISKWVRKVVFKLHDTYNNPTRTIESPPFEVIETGWGEFDIMVRIFFAPEAHEKALTFYHHLKLHPYGPRMEEMKASGGLVESVQYEEIVFNEPFEYTYKLLSQNPIGDGHGLAVESEPDHPFSQQLEQDEADKLDFAIQEVKKTIEMYKQQVQSLQGQKSSTPVE
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSQRKSLRSQQLARLSSISSDSESDSEYDTEERFGRWIGEPHKVEGGRVYYNALSKNEIVFRIGDAVTIYDGDSSYYVGIIEYLYEKNNRSKAMGEKYLQLIWFTRAFAKRMELKKDLLLPDRHLCELYMTPGRDENLTSCVLDKVNVYNEAEFFSKFPKGISPKNKRLLETNFFVRKGVNMRAKRYTENIDWSEYRENIKKIKELVWYLEEKLAPSLTSAKRKRAKEDDYKFYSEEDDDSLQEAELLPSDDDEFGPSPFRDTSNSVPKTPRRRKKKAKASSEPSSTLTTPRRSAKKPLQITPLPMRVMPLNEFQGSPHKKARALLHVSAIPNSLEGRDKEFTTIFSSIESALEEGTGACLYISGTPGTGKTATVHEVIWSLQDMATKNQITDFTFCEINGMKVTTATQAYAQLWESLTGDRVTPKHAMELLDKRFTLPSPNRNPCVVLMDELDQLVTHNQKVLYNFFNWPSLPHSRLIVVAIANTMDLPERVLTNRISSRLGLSRITFEPYNHMQLERIISSRLELVKDELLFTNDSIQFAARKVAAISGDARRALDICRRASELAENKNCKVTPNLIYQAILEMTTSPLQSLLKSLSFVQKVLVCAVVNRMRRSGFAESFLCEVMDEAERLKTTSEKFSSSSVSQTRKADRLQYRYALSSLVESGIFLIDGKQTRHSRVRLAIGDEEVKMAFRDDSELRGIA
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Subcellular Localization:
Mitochondrion.
Sequence:
MQRSASIFRCLLRARSFSSSSKPWSVRASVCKGLPLINQAERCLRSSTLFTPRLLYQLQKPCRFYSSEDLPAHYKITLPALSPTMEVGTVVRWEKQVGDQLNDGDLLCEIETDKATMGFESSEEGYLAKIFVEEGAKDVPVGRLLCIIAEQESGVEAFKDFEDLGVIEAPQGPPAPVKESPPAQVAAPPPPPPRPPPPPAAATPSTTPRPPPVPMAAPAAGATQGRVFASPLARKLAAERGININTLQGTGPGGRIVKADIESYVPGVAGVPMPAAVPGAGFTDIPVDALRMEQANAAVYSKQTIPHYYLMADIDVGSVLRLQGSLNEMVSEDTPITLNEFVIKAAALSCQKIPDANSAWFGDKIRQYHNVDVNIAVTSDYGTVTPIINAANTKGLEAIRQEVDYVTALAQDGKMQTQGGTFSISNFGEFGVRGVAGIIPSPQACHLGIGAVQERFVPDEDAEEGYRPASIVTVTLVCDHRVVDGAVGAQWLQQFKRYMETPHSMLL