lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasmic vesicle, autophagosome. Mitochondrion. Note=Colocalizes with UBQLN1 in the autophagosome. Colocalizes in the cytosol with DDX1, DDX21 and DHX36. Colocalizes in the mitochondria with DDX1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation.
Domain:
The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of TICAM1 recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines; The N-terminal region is essential for activation of the IFNB promoter activity; The N-terminal domain (TRIF-NTD) is globular and consists of two alpha-helical subdomains connected by a 14-residue linker. It shares structural similarity with IFIT family members N-terminal regions.
Sequence:
MDNPGPSLRGAFGILGALERDRLTHLKHKLGSLCSGSQESKLLHAMVLLALGQDTEARVSLESLKMNTVAQLVAHQWADMETTEGPEEPPDLSWTVARLYHLLAEENLCPASTRDMAYQVALRDFASQGDHQLGQLQNEAWDRCSSDIKGDPSGFQPLHSHQGSLQPPSASPAVTRSQPRPIDTPDWSWGHTLHSTNSTASLASHLEISQSPTLAFLSSHHGTHGPSKLCNTPLDTQEPQLVPEGCQEPEEISWPPSVETSVSLGLPHEISVPEVSPEEASPILPDALAAPDTSVHCPIECTELSTNSRSPLTSTTESVGKQWPITSQRSPQVPVGDDSLQNTTSSSPPAQPPSLQASPKLPPSPLSSASSPSSYPAPPTSTSPVLDHSETSDQKFYNFVVIHARADEQVALRIREKLETLGVPDGATFCEEFQVPGRGELHCLQDAIDHSGFTILLLTASFDCSLSLHQINHALMNSLTQSGRQDCVIPLLPLECSQAQLSPDTTRLLHSIVWLDEHSPIFARKVANTFKTQKLQAQRVRWKKAQEARTLKEQSIQLEAERQNVAAISAAYTAYVHSYRAWQAEMNKLGVAFGKNLSLGTPTPSWPGCPQPIPSHPQGGTPVFPYSPQPPSFPQPPCFPQPPSFPQPPSFPLPPVSSPQSQSFPSASSPAPQTPGPQPLIIHHAQMVQLGVNNHMWGHTGAQSSDDKTECSENPCMGPLTDQGEPLLETPE
The following text describes a protein:
Function:
Binds glycine-betaine.
Subcellular Localization:
Periplasm.
Sequence:
MNRLIRSLCLACAGLFAAGLAQAETLRIGGKTFTEQRILTAITAQFLQKRGYDVTVTTGLGSTLARAAQESGQLDIVWEYTGSSLIVYNHIDEKLDAAASYRRVKQLDEAQGLVWLKPTRFNNTYALAMPEEQAEHLGIQSVSDLARVLAEQQEAEPGSTHLFAMDPEFAGRPDGLGPMSELYGLHFTRNDIRQMDAGLVYTALKNRQVFLGLVYTTDGRLKDFKLRVLKDDKQYFPFYNAAPVVRKEVMQRHPEFATLFDPIIERLDDATMQALNARVDIEQQTPQKVAADFLREHHLLDDGQAGQGGSQ
The following text describes a protein:
Function:
Chaperone that specifically binds and folds some, but not all, nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MELEAYIQSLGLGIESYSQSATQFHDEANQSFNIPISTIIKLKEACRELETSKVVAKSLNWSHLLRVISLLWEKDVSLELMKLLANCLRQVPSISVQIVHNESLKQLTTSVFEVRAPKVLSLISTFNDDLERRVVFMRFLFILLSTQTDDICLDMRQVRTQLIQMLKKMWTLNSSPSNNSQDNEMVLTEILRLLFPISKRSYLKEEDEQKILLLVIEIWASSLNNNPNSPLRWHATNALLSFNLQLLSLDQAIYVSEIACQTLQSILISREVEYLEKGLNLCFDIAAKYQNTLPPILAILLSLLSFFNIKQNLSMLLFPTNDDRKQSLQKGKSFRCLLLRLLTIPIVEPIGTYYASLLNELCDGDSQQIARIFGAGYAMGISQHSETMPFPSPLSKAASPVFQKNSRGQENTEENNLAIDPITGSMCTNRNKSQRLELSQEEKEREAERLFYLFQRLEKNSTIQVTNPIQQAVNSGFIDVVFCLIFQMSSESFIYHCYHSFVGPIHILLLMFSTFKFHEILHFIKISKAS
The following text describes a protein:
Function:
Flagellar protein involved in flagellum axoneme organization and function.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Closely associated to the axoneme along the paraflagellar rod.
Sequence:
MATNARILGFNSPSALVAAGDDFLLGAGGGIVIRRKEESSQWIPCEGRYAIGALAFSPSAGLLCVTEVKLDVSLHVFRFPERHHLQCIDNVATVDVQHMLFSSDGEMLALLTCIPTTCVTFYSAARGNRLVKCASTELGGVFCKHLTFPLHRHDCIAVLEPHGVRIACNMDSATFVPSILTLSSKGHYFHSCVWGTEGLYCGAGRGQVVLLDELRTDMKNYINCETPHNVTALLQNGTLLFIGTECGDVFTYNIDQKAQRLLVRLGRSVVRLLTLPDVNDVLVATSTDVTKISVDTAQSVFVRRRSASDTVKLLVLGGLVVIVCLDGSLVTYDQDTNTAGHTPVRFPEKVVDACVVGSVAVVVYDSGFVRSFTVENTVSVVSQMKVSDCPLTACTSDGVSLLAVCDKNVVHFIEVADGLLETAASSDIFACAVTNLRWAVNGGRSVLAACNNGEVHNLRFTGKCDSASAGVTVDMTWRLDFPVNDFLPLYGDGDVINIFVHSVDKDTKMYALERQRVKESKPLRPYFLMRDHECGGNVLQRLGGDSIISAGGDGRVVVRDISHYLMKLPPVPPTKEKKHPLKEFLLRPFGRGGITCLSVWNAAGGFVCGGNDSVVHLVPVGKSPIHYSWSEPFWHQRAISTSPSRASSPSDAETLSAERSRCRIISALADLRMEVEKLLQERTPTVRAEDFLLPEQRQAFNEECEMEIHKAREDDYYSLVHNEFVQHTIKTECWDVMEVQRSKIVSMTDPETEVHNFHLRKPCAQRAKIQKKIKLMRAIQIKTEECFTLSSLVKRAKEGNLCTEQQVCGPPSDVDELLYDTLDVYTGPRATIQLILLECKILHEKKSFNIRFDTLRERKSRELNLIAERNGRCVRIMQQLGEHTCPPNVLFTPVFDIEEDPQTVFEVFDSEIDPELLKLAVKSDDGELVVSPSDEAALKTWMDGLEKVTEVLRVNVPIPPFADNSLEQYVPPEERSDEQQRIFEEYEKEVAEQTVLINEKKELLRGEVAALVKANMTSAKAIDDEIDVLRTDRMLVAQLVDELELHQVNALCLFLLKKTIRNKFLGVKREEEDLLCRLRQLDSLYEYRLKLYLASEARVQDCIEEEKNMITDMRCLPPFTDPDWGERLNRRFTTWRSKYEDGLAKVPEPTRSGVVPIPLWEQYCQCCRAVVEARDKIIHLRGEADALNDEVVEVETEKKKAQFALDDKEKAEEACRKEVIEKVLDIQNLYTLQQGQVQDENAMVSDDFTDFSIRWVKNITDYNDLIFASFDEIRSLMSRSSQLRQSMKTCSWETERLLYCIGTLEMELRQLHTLRVTRQMQETIHTGAVTSLEREINKMDARIEAVRSVMSKKVEERNRVISKLKMQINDRRAENQYLNNQVQALTNSVEDKKAVWGMLGEHNNDKDRLRERMRELYENSELEELARCQQEELVRLKNEVDRLREATFPSFAVVTRRTAR
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence:
MFDPMMDDFDDVSAQSTDVVTGGFRKLPVDDSEDDNAVSVADAPEGEVQLDSPDELIALDESETWSDDPVRMYLTQMGEIPLLTRRQEIELAKRIEETRRRFRTKLLENHYVLVEAYKTLKKVYRGQLPFDRTVQVSVTDRLEKEQIIGRLPHNLKTLQTLLNRNRHDWKVAMSKSAPARRRAEAWRALARRRRRAVRLVEELGLRTQRIETRIGLLEKFSRRLDEIDELVRQQKRTKHGREVREQLLHERRQILTACQETPTSLRNRVKMLGSVYSDYQQAKRELSEGNLRLVVSIAKKYRNRGLSFLDLIQEGNAGLMRAVDKFEYRRGFKFCTYATWWIRQAITRAVADQSRTIRIPVHMVETMSRVRNVARQLLQELGREPSIEETARRADVTIEEARRVLTMSRFPISLDRPVGNSEDSQFGDLLPDGTAESPQIGATQEMLRQRITGVLKSLSYREREIIKLRYGLGDGYSYTLEEVGHIFKVTRERIRQIEAKAVRKLQQPSRSQDLVGFLD
The following text describes a protein:
Function:
Required for the biogenesis of long polar fimbria; binds and interact with LpfA.
Subcellular Localization:
Periplasm.
Sequence:
MNRSRLISCTALVLALIAQNSFAGGVALSSTRVIYDGSRKEASLTVNNKSTTDEFLIQSWIDDANGNKKTPFIITPPLFKLSPTKNNVLRIVNTTNTLPQDRESVYWINVKAIPAKSEDAEAKNVLQIAVRTRLKLFYRPAGLKGNSMDGWNKLQFTSAGANQIKVENPSAFNLTFNKFYANGRDIEKTGMVPAKGSLNIELPAGTGKVSEVKYNIINDFGTAGDMLTQRVN
The following text describes a protein:
Function:
Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-2 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17. In contrast, smu-2 mutants do not suppress the effects of an unc-52 mutation that affects the 5' splice site of exon 16. Required for normal accumulation of smu-1.
Subcellular Localization:
Nucleus.
Domain:
Intrinsically disordered protein (Probable).
Sequence:
MADNPTNLRNADFRKLLTSARSDRPAVSAFAKPADPKTGDDKPASFKHKHLKPAKFKKPQAAAHGKAKKEKTEADEDEAALKNILKNYRDRAAERRKQGDEKEDPSKLTAAYRAVPGDARSAQDQADLRKQAILESKYLGGDLEHTHLVKGLDYSLLNKVRSEIDKSDDDDDDDIDTAFDEKVTSSSSSSKPSEASLLAQELAQSHSENRMVRSLHRVLFKNEVPLHNQLFAKGRMAYVVELEDEETDIPTTLLRSLHDLPRAESAQSIQANNLIILKLSHVLSHLRAEPKKKKKEEFRVQLGSRDAPGAAAAAPGAKGDSIYDDLDDYVPSRKSRDSRDAGRRGSRRDRSRDRSRDRDRDRDRDNRDRYFEKSANSRREEEQNRREQQRERERAEQERRREREKEREQEKAKEREKKRKELEESSGYDECYPGGLVEMGGAWDSDEEADYSKMDAGPKKNQAVNRWDFDTEEEYASYMEGREALPKAAYQYGVKNGEGGRKNKKQSAVSDAKRLDRELNEINKIMDKRKAGGDGAGGGGDYKKPKY
The following text describes a protein:
Function:
Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, septate junction.
Sequence:
MRPPRSNTKAAFSSLQFGLLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLTERGPDKARLNGNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHHDFYSGGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKNGFVGCMRLISVDGNYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIAENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIETRPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGDYLTHEDQGADGADDPDDAVLHSTTGHQVRKRTEIFI
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATSPLYRAPIYHVITILTRDSSCHERFQFITEMNVYFNWPLVFKKGEYWRLLTTFLYLKTNALDFYLYMSFFVRFMSTLEESSPPPQTKNFLRMVLTIAGCLILAAQVFYMPFIANYFSYTMLYLWAWRHPQYRVSILGLVDVKAPFLPWMLLLLRWASSGRWPATDCACAFIGHVYYFLTDFRQT
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MVVRPRRPLVSLEAQLQQLTLFTDLDADSENLEQLGPIIKSLDEARQQDAFLRHLKTFVRSKDREIEAVCDDNHSEFVAAVDKLLKVRSGTVTLKHRIGELNEDLQAGGSSLANKKRQLLETQRTASNVNDAISAVEVCLRVLDMANRVDALISEKKYFAALRSMAELETKLRGLLGHEFTKHMMEGLPQMKEQVKSAVTREMKEWLFQVREKSQTVGQMALEAMELRQKRWRVKSQRDPLLRLAKVNSAIELVVNERTESNFVDNDKVSVDFRPLYQCIHIYDALDAREELQTSYQEDRRAQANLLLNQGLTFDTAGTVPALLEEMVGFFLVEHHVIQTTPVGFREESEVDDLWDTMCSRVVEIVSLALRDCKDTKIYVSAKASIQTFIQTLEGYSFPVAKLNALLLTLFERYAQLLRDRFSRDFQQAMHDTQHEPMVVSNAEELQKVLSVCWLKPGDDAMLRSSGFPLSLPFSQTYPLCCMDMRNLVDQYYIFSDGFQNHREIDEILKKSLDELLITQVSTAIRKSLDNTRASINLSQIAQIVVNAEHFNLACLELEKLLTALRAPHGRGGKMSLDASHHFTATLRIAEDKINQAFAAKLDQFLGLAEYDFAPTPETARVRSMGRATHSAWLQDTVDWLRTMMESVLVLLPPGVKSIVYTAAYRHLSGSLLDRHLLSAETTQVNVQGCELLLVDLNFLSSAATQDGVDASIFDPVTQTLQLVVLDKVSEYTMLVQGGKVAIEAGARWARVDPKKLLMLLDKFIKTAGPRRTGGTQAQAETAELTKRQREKEMLARAIALTNTSIARP
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. May prevent formation of excessive Holliday junctions or assist in their resolution.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome.
Sequence:
MNSALKAIIELCIEEDLLPKSLDVLEYLLSTTSIPIPACYIRMCITLLVHPEYPTSSNIQESCNWILQQVVENRSKINFDAWSFENDLSDNDMPKENYLKIFSNQCLFTQDVDYWDLIAYMSSRPPDLERWMSLMDIWLRILEIDAEENGSALMKKYMGEDLCELQDAIRICFSCFTLPQQTMESPFATSMSKAPAKTESRGSNSFEGTSRLANLGAKLLCLIWAMLPKGRFFVVHLTDAFHFLSKLDERFSKLNAKQQDLFFGNLGASNLRYCLSQYILMKGIGIGINIRHTRCEFTKQLTQLLPTSLPKNKIRQKLHLRAWVSFLGSALRESDRNFDKELFYTTLKQLYTMYQQTELVGIDRPMAILKDMLVLLDISKKLSLDKIV
The following text describes a protein:
Function:
Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The C-terminal domain contributes to sequence-specific DNA-binding.
Sequence:
MLAVGAMEGPRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPSSSSSSSSSSSPSPPLGAHNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGTSENEEDDDDYNKPLDPNSDDEKITQLLKKHKSSGGSLLLHASEAEGSS
The following text describes a protein:
Function:
Component of the gamma-tubulin small complex (gamma-TuSC) involved in microtubule (MT) nucleation for the formation of median bodies and in the biogenesis of flagella. Gamma-TuSC may be required for the correct positioning of EB1 within the trophozoites.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Cytoplasm, cytoskeleton. Note=Localizes to basal bodies, axonemes and median bodies of the trophozoites during interface. Colocalizes with tubulin gamma chain.
Sequence:
MSSVFADPRVKELLNLHRSPKLATEGKTPPSQVQDLVNKYSRLGSNVVSHPTRSSPEKTTDKPADSKPSIPPLKSESVMTRLTALSSNNTTQNVASLVTAIASHPATAALPKQEASQQPVIPTSVEKRAVTQPLSQQNMNKLMNAIDPQAAPLIEDQVAGKHTGTKPLLTLQQQQAISSLPTKSERESALNEIALNTAIQSAQHANMELSKAGITFPMWFFGVQNQSDLVSRSFISLAHIQQPMVMNDSLLQEHLLVSDCIAVLQGCMQTTYLQVSEQNKEYVVTIRKEVATELPATLVAMTQRVLVHAHARFQIVNTIYTHQVPEYGRIANAFSQALRCIIKEYDFYLADLSKKHYGKMQSSAERGSLSLQTLEVKTKQIHIILENVADLCSRLGVVRGCALLQQLETAVLQSSGLSVKEVFQYLLSESLKPLGRIMDRYINEAVIPDSDAADFFIRKSHSTELAEEQGKTTINTWMQMFKVDDAQVPLFLNNIKTHLCDIGRSTVLLKWKKKQYIDKGPNASGQELLLLSAEASGETTQGFRHGEETVASLVCGDGSTGDLELAHIRLYKQLIDINARVQTKVLDFFINPEYLDFRGHLQNIYAFYLVMAGDFLSCFVESAISELVLSRSVANILRIRSKFKMVIKTSSLANLPYNERMNVIVCPELFKHHLNSVLYPQTYVPDRATDSPDPKVLNLLGLQYDVTYPLNLVLTTPVMERLNLVFRHILRAKVSEIELQKAWTTLQRLRKLERVPHDKIEVYANALRSDKSPIIIFFGVAYKMLITMLDFIHSLQFQYVTILTECIAKFQDTLVNAKSLDDLVSGMSAFANGLIMSLGLVSNNVVNILDTLFNDCIVYSHHIVKTFCIISNEDDEFIRKIVTINEESREGKSGPRGVKGSERMTSLLKKREAIEMTRLIAIANSVYSLIVDNRGLIATLMTKFNKGVASYEQVIRNFDDR
The following text describes a protein:
Function:
Plasma membrane transporter which mediates resistance to water-soluble, monocarboxylic acids with chain lengths of from C1 to C7 by active extrusion of the preservative anions from the cytosol. Also involved in the export of aromatic and branched-chain organic acids produced in amino acid catabolism.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSTDEHIEKDISSRSNHDDDYANSVQSYAASEGQVDNEDLAATSQLSRHLSNILSNEEGIERLESMARVISHKTKKEMDSFEINDLDFDLRSLLHYLRSRQLEQGIEPGDSGIAFKNLTAVGVDASAAYGPSVEEMFRNIASIPAHLISKFTKKSDVPLRNIIQNCTGVVESGEMLFVVGRPGAGCSTFLKCLSGETSELVDVQGEFSYDGLDQSEMMSKYKGYVIYCPELDFHFPKITVKETIDFALKCKTPRVRIDKMTRKQYVDNIRDMWCTVFGLRHTYATKVGNDFVRGVSGGERKRVSLVEAQAMNASIYSWDNATRGLDASTALEFAQAIRTATNMVNNSAIVAIYQAGENIYELFDKTTVLYNGRQIYFGPADKAVGYFQRMGWVKPNRMTSAEFLTSVTVDFENRTLDIKPGYEDKVPKSSSEFEEYWLNSEDYQELLRTYDDYQSRHPVNETRDRLDVAKKQRLQQGQRENSQYVVNYWTQVYYCMIRGFQRVKGDSTYTKVYLSSFLIKALIIGSMFHKIDDKSQSTTAGAYSRGGMLFYVLLFASVTSLAEIGNSFSSRPVIVKHKSYSMYHLSAESLQEIITEFPTKFVAIVILCLITYWIPFMKYEAGAFFQYILYLLTVQQCTSFIFKFVATMSKSGVDAHAVGGLWVLMLCVYAGFVLPIGEMHHWIRWLHFINPLTYAFESLVSTEFHHREMLCSALVPSGPGYEGISIANQVCDAAGAVKGNLYVSGDSYILHQYHFAYKHAWRNWGVNIVWTFGYIVFNVILSEYLKPVEGGGDLLLYKRGHMPELGTENADARTASREEMMEALNGPNVDLEKVIAEKDVFTWNHLDYTIPYDGATRKLLSDVFGYVKPGKMTALMGESGAGKTTLLNVLAQRINMGVITGDMLVNAKPLPASFNRSCGYVAQADNHMAELSVRESLRFAAELRQQSSVPLEEKYEYVEKIITLLGMQNYAEALVGKTGRGLNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLDSQSAWSIVQFMRALADSGQSILCTIHQPSATLFEQFDRLLLLKKGGKMVYFGDIGPNSETLLKYFERQSGMKCGVSENPAEYILNCIGAGATASVNSDWHDLWLASPECAAARAEVEELHRTLPGRAVNDDPELATRFAASYMTQIKCVLRRTALQFWRSPVYIRAKFFECVACALFVGLSYVGVNHSVGGAIEAFSSIFMLLLIALAMINQLHVFAYDSRELYEVREAASNTFHWSVLLLCHAAVENFWSTLCQFMCFICYYWPAQFSGRASHAGFFFFFYVLIFPLYFVTYGLWILYMSPDVPSASMINSNLFAAMLLFCGILQPREKMPAFWRRLMYNVSPFTYVVQALVTPLVHNKKVVCNPHEYNIMDPPSGKTCGEFLSTYMDNNTGYLVNPTATENCQYCPYTVQDQVVAKYNVKWDHRWRNFGFMWAYICFNIAAMLICYYVVRVKVWSLKSVLNFKKWFNGPRKERHEKDTNIFQTVPGDENKITKK
The following text describes a protein:
Function:
Catalyzes the sequential release of Tyr-Pro, Phe-Pro and Gly-Pro from the N-terminus of peptides and proteins. Is able to cleaves bioactive peptide beta-casomorphin.
Subcellular Localization:
[Isoform 2]: Cytoplasm; [Isoform 1]: Periplasm.
Sequence:
MRLALFALFALMTVATALPAHAEKLTLEAITGSAPLSGPTLTKPQIAPDGSRVTFLRGKDRDRNRLDLWEYDIASGQTRLLVDSSVVLPGEEVLSDEEKARRERQRIAALSGIVDYQWSPDGKALLFPLGGELYFYDLTKSGRDAVRKLTNGGGFATDPKISPKGGFVSFIRDRNLWAIDLASGKEVQLTRDGSDTIGNGVAEFVADEEMDRHTGYWWAPDDAAIAFARIDETPVPVQKRYEVYPDRTEVVEQRYPAAGDHNVRVQLGVIAPKTGARPRWIDLGKDPDIYLARVDWRDPQRLTFQRQSRDQKKIELIETTLTNGTQRTLVTETSTTWVPLHNDLRFLKDGRFLWSSERSGFEHLYVASEDGSTLTALTQGEWVVDSLLAIDEAAGLAYVSGTRDGATEAHVYAVPLSGGEPRRLTQAPGMHAATFARNASVFVDSWSSDTTLPQIELFKADGTKLATLLVNDVSDATHPYAKYRAAHQPTAYGTLTAADGTTPLHYSLIKPAGFDPKKQYPVVVFVYGGPAAQTVTRAWPGRSDSFFNQYLAQQGYVVFTLDNRGTPRRGAAFGGALYGKQGTVEVDDQLRGIEWLKSQAFVDPARIGVYGWSNGGYMTLMLLAKHDEAYACGVAGAPVTDWALYDTHYTERYMDLPKANEAGYREASVFTHVDGIGAGKLLLIHGMADDNVLFTNSTKLMSELQKRGTPFELMTYPGAKHGLRGSDLLHRYRLTEDFFARCLKP
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA.
Sequence:
MRLDKFIAQQLGVSRAIAGREIRGNRVTVDGEIVRNAAFKLLPEHDVAYDGNPLAQQHGPRYFMLNKPQGYVCSTDDPDHPTVLYFLDEPVAWKLHAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYLVTLESPVADDTAEQFAKGVQLHNEKDLTKPAVLEVITPTQVRLTISEGRYHQVKRMFAAVGNHVVELHRERIGGITLDADLAPGEYRPLTEEEIASVV
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MAKPQLLLCLLVAAAALLLVASAKKSADVTELQIGVKHKPKSCSIQAHKGDRVKVHYRGKLTDGTVFDSSYERGDPIEFELGTGQVIKGWDQGILGMCVGEKRKLKIPSKLGYGDGGSPPTIPGGATLIFDTELVSVNSEPATKSDDEDEL
The following text describes a protein:
Function:
Processes the pre-form of the ubiquitin-like protein NEDD8/RUB1. Has the capacity to discriminate between NEDD8/RUB1 and ubiquitin. Has no SUMO protease activity.
Sequence:
MGNTSDDDKILSYEDVVLRRSDLDILNGPIFLNDRVIEFYLSFLSTVHSSTTISLIPPSIAFWISNCPDTEYLKDFMKPLNLRDKDLLILPVNDNSNVEVAEGGLHWSLLVYYKEANTFVHHDSYMGVNRWSAKQLFKAVSPFVSNGDASYKECTDTPQQKNGYDCGVFLLATARVICEWFSSGGMKNRDELWFANVKETVPDLVNHLREEILALIKKLMSESVSK
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL.
Subcellular Localization:
Cytoplasm. Endosome membrane. Nucleus. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6.
Sequence:
MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTSGEDTEEEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF
The following text describes a protein:
Function:
Regulates the activity of the neutrophil proteases.
Subcellular Localization:
Cytoplasm.
Sequence:
MESFSYLLYRKGGNLYGCVGKKQCDTGNKTEMENLSSACTHFCFDLFKKINENNSTGNLFFSPISLSTALAMVFLGTKGKTAEQMSKTLHFDAVKDLHSNFQTLNAEINKKDVSTYALNLANRLFGEKTFNFLPNFLSSVKKQYSADLGTVDFISALEDARKEINKWVSEQTKGKIPEVLSTGTVDRSTKLVLVNAIYFKGDWAKKFNAEHTTDMPFQLNKKEQKTVKMMYQKEKLPFNYIPDINCRILELPYVDYELSMIIILPDNINDDTTGLQQLEKELSLEKIHEWTENMMPTDVHIHLPKFKLEDSYKLKSQLAGMGMVDLFNSGSADLSGMSGSNNLFLSEVIHKSFVEVNEEGTEAAAASAGIAMMCMMREEEFNADHPFLFLIRHNATKSILFFGRYSSP
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 localization in axon development and positioning of neuromuscular synapses in DA9 regions by negatively regulating synaptogenesis. Plays a role in motorneuron development by promoting the extension of the anterior neurite of ventral D-type GABAergic motorneurons along the anterior-posterior axis of the ventral nerve cord. Positively regulates cilium position and dendrite morphogenesis in postembryonic PQR gas-sensing neurons. This is likely through regulating the localization of grdn-1 to the distal dendrites of PQR sensory neurons.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRAAPFDFFFQSTALSTFFILCSLATNEIPTISGAPAGKIVQPPKPNILKQGCPSDLLHSRALRSIQLACRTHPATVISAFEGVQEGLQNCANRLRFQQWDCSEAGNIMHDPPLLRQGFRESSLIWALSSASAAWGVATACAQGWIDDCACNNQMGQNEYEFGGCTHGVQHGITASRKLLTKVGAVNTLLRKVEKHNLKAGRLAIKKTLISSCKCHGVSGSCQQKTCWKRTATLEHITDYLVEKYARAKLYTDDSVVKTTDLIYLEASPDVCKAKSVAGRVCAWRNETHTQGDCDRLCCGNGFSIRHEVVRVKCDCEFVWCCNLVCKDCIQHRWISTCNGTPPKSLIF
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MGFWDAVTDLIDAATPWATVEAEAPADTPAETAPASESTEETTAETKAEESAPAAEEPEEEAEEEEEEEEDEDEIVDPKETLEEECRNSKECAPAKHHYDECAARVTGAGADNKEDCVEEFFHLVHCATQCAAPKLWNTLK