The following text describes a protein:
Function:
Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Sequence:
MGEPSSFLHIGDIVSLFAEGSVSGFISTLGLVDDRCVVQPDAGDLSNPPKKFRDCLFRICPMNRYSAQKQFWKAAKPNPSNPADAVLLKKLQHAADLEKKQNEAENKKLLGSVIQYGGVIQLLHLKSNKFLTVNKRLPAHLEKNAMRVTLDPSGNEGSWFYIQPFYKLRSPGDNVVVGDKVTLMPVNAGQPLHASNYELXDNPGCKEVNSVNSNTSWKVSLFMIYTENIDDVLKGGDVVRLFHAEQEKFLTGDEYKRKECVFLRVTARQSATSATSSKALWEVEVVHHDPCKGGAGHWNSLFRFKHLASGTYLAAEIDHDPTPDTQRQKLAGPQGGMVYQLMPIPHGHDIASIFELDPTTMQRADSMVPRSSYVRLRHLCTNTWVHSTAIPIDKEEDKPVMLKVGAAPIREDKEAFAIVPVPANEVRDLDFANDACKVMQDIASKLEKSSITQNERSSVSQLPTRPAINNVLSKSVRRFVTQLLTDLVYFLADKPNNGGDPLDVQITNPNRERQKLMRDQNILKQIFKVLQAPFEDKGDGPMLRMEELSDQRHAPFRHICRLCYRVLRLSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIETFVSLVRQKKECRFLEYLSDLCVSNNQAIPVTQELICKSVLKPANSDILTETRIVKTEVEEVIEDEEGEDGEPITQIVEEEEVVLFWEKGHKHKAIRELAADAEESKEDKQVMDYYRYQLDLFSQMCLDRQYLAINILSTQLDINLILQCMSDESLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSKITIEDYDSTRDKSKADMRPRFEDTMRFVERYLRHNLADNARGWQFADRNQNKLTFEVVNLSRHLVYFGFYSFSDLLRLTQTLLSILDITNSTTPVLALGKMDKVSELANGATEQKQVCASTLMCSVGWWDVPNHQMGKTGVFKSLHDVSAVMTTMVLGGGGMSGGKALKAGDGEMDTIVMDTKLKIIEILQFILNVRLDYRISCLLSIFKNDFDESNSSQRGDTLPGLGTNAQDNSVVDLEKIAQQAESIFDGSDESADLDLDGAGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVSSSDVENYKQIKADLDELRLLVEKSELWVYKSKSEGGKKKKDKKDKKDKDKKKDKEEKKESSTGDGDGDKKKKSEGGADKKEGKSRGKLMSQESSIGDDDIIYPVRVTREQWIQSVHMSKANTALKGMSLTSSQGPEGSAIDLDIGPSMDQNSVKNYKTIQQVLIRLSQLCVHQSSGKNRKHEQRLLRNMGAHSVVLELLQIPFDKKEDTRMNEIMRLAHEFLQKFCQGNPANQALLHKHVDLFLTPGLLEAETMRHIFMDNSMLCNEVTERVVQHFVHCIETHGRHVQYLKFLQTIVKAEGQYIRKCQDMVMAELVNVGEDVLLFYNDRSSFNTLIEMMRSEREKRQLSSPLMYHINLVQLLGLCTEGKNVYTEIKCHSLLPLDDISRVVVHPDCLPEVKDAYINFLNHCYVDTEVEMKEIYTSNHMWTLFENFLVDMATVCKATDRNHADPVLEHYVTNTIMNIITMFFSSPFSDQSTTVQVFLSPQLRAVVNSMFFTRQPIFVQLLSGAYRVSQCTWLNTQQRCMVETCIKTLTEIVKKRNMLVPVDLGAHINMPTRSRREMWRESSRSIVGGNSIAESKNRGIAIPVDLDSQVNTLFSKSQLLMATSRKWLSTRGSSRRDSIMAISRDTRSIIEGLQQWQDLVPPPMAANRRIVELTTKNLPQDIVSLLEDQLRPLVQAELSVLVDVLHRPELLFPPGSEARQNCESGGFISKLIKHTERLLEEKEEKLCIKVLQTLKEMMTTDIDYGEKIYPVEGEDLFTTMKPRDEQSKKQIDDAKRGDKLRSSLLTRYYGKQHPRADRNRKESGSPNAQPPQRPSVANPAPGAQMVGRAEMSLAEVQCHLDREGASLLVTDLVINSTSNRVFEEAVELGIALLEGGNSTIQKSFLNHLRDEGKAEKFFKVFYDRMRESQQEIKATVTVSTGDSLSGNKDNKDVAVKDTPAKMKKGAGGGSPGTAMSDDVRDQLADAALQTSKAFGAMRQGPQGEDAANPLSGFDKETEKKNEERGMSPEIAIMKPILRFLQLLCENHNRDLQNYLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVDLINQTLASLTEYCQGPCHENQNSIACHECNGIDIITALILNDINPLGTHRMDLVLELKNNASKLLLAIMESRHDSENAERILYNVSPKQLVDVIKRAYMQEEMKEDEEDEESEEDEEEDKVSPKEVGHNIYILAHQLSQHNKELAALLKPSSAADYGNTALEYYAKHTAQIEIVRQDRTMERIVFPVPSICEYLTEETKSRVYHTAERDEQGSKVSDFFERCDDMFNEMKWQKKLRANPTLYWISAHMSLWSAISFNLAVLINLLIAFFFPFSGGTGELDPRLSGLVWTAMLVSLATVITLPKASGIRTLVASTILRLIFSVGLEPTLWLIGCANVINKAVFLVSLLGNRGTFTKNLQAIMGDVELWYYVAYLILCVLGLTMHEFFYSVLLLDVVYREETLLNVIRSVTRNGRSIVLTAVLAVILIYLFSIIGYLFFEDDFLVDVDPAPHLMPALAGGGMMCTQEGGCAGADSPMAAMFGSNNTENATDVVLPVVEEGGDDQKERACDTLIMCIITTLNQGLRNGGGIGDVLRNPSSKESLFVFRVMYDLLFFFVIIIILLNLIFGIIIDTFADLRSEKQQKEEILKNTCFICGLNRAAFDNKSVSFDEHIKEEHNMWHYLFFIVLVKVKDPTEFTGPESYVYLMVKDKDLDWFPRMRAMSLAVDEGDSEQSERQNLQAQLEATTKLVTTLSTQLTELRDQMTEQRKQKQRIGLLAPPGLPQIPPQFQPQQQQVPPPVAVNP