lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adapter protein that regulates different signaling pathways (By similarity). Required for larval development and viability. Involved in negatively modulating pmk-1 p38/MAPK signaling. Involved in innate immunity, acting either in a manner dependent upon, or independent of, the pmk-1 or pmk-3 p38/MAPK pathways. Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa, acting by negatively modulating expression of cebp-1, and regulating the pmk-1 p38/MAPK pathway, leading to activation of transcription factor skn-1. Required to prevent P.aeruginosa toxin ToxA-mediated lethality, probably acting via modulating the effects of translational inhibition caused by the toxin. By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29 and nlp-31, plays a role in resistance to fungal infection.
Subcellular Localization:
Nucleus.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MARTKCKTKTVANPRTGVRKTAKDLSEPVRQDAVSRRRPTTLPFVGNTSSRPRVFYDVLAKKNVVFPNVKAEYHYRVRNAPKIDPKNFGTTLPICYSSIGPAKTLELRPLGRLPPHIIKALNDHYVQLTRGSMVPAADLYNNGDHPAEQRIPTMLNENEYLRLIQELEEEEKSKQFSATSSSAPHVNPYSAQHLVNGEIIGIFVIYGTGLVTRAVCSQTREMFTAHVLPEWKASKVIDVIRRLQIPTDISSMTADEIRLSELCISKRMEIIKSNDRYILMNPCESATIHSYATERLDEITENDVMSIYQKVVEIVRFCHSRKVILQNFKPRSFYLKKDAHNKWVVRPCFLQDMSCEEDQSEAQFTRRSVCVPFMAPEMLTAESRTHHSYSTELWGLGVLLYILLTGKYPFHENSMPLLFRTIKFKQHRWPFNFISSKSRNIVNMLLKKAPATRMNLEDLWNQVNGDFPEIRCRSNIILKKQDMIVKMDLFEMYYNTYKDRLLPKNVLPMYEEMKACRNDSTILTEMAKRDFRSIQEQMKRRIETKPTEYQTLVMQVRLQQINQLFFEKEVSQAQKQHRAPRLVQLKCSDISKELLLPGDIYPISEHYHPSQQPVDKVVYKLLSDANSLAFPTVMKGTVPKSYPPPVFKGLDISPS
The following text describes a protein:
Function:
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
Sequence:
MTAISPIQDTQSATLQELREWFDSYCAALPDNDKNLIGTAWLLAQEHYPADAATPYGEPLPDHFLGAAQMVHELDLLPDAVAATLLADIGRYVPDWNLLVSERCNSTVAELVKGVDEVQKLTHFARVDSLATPEERAQQAETMRKMLLAMVTDIRVVLIKLAMRTRTLQFLSNAPDSPEKRAVAKETLDIFAPLANRLGVWQLKWQLEDLGFRHQKPEKYREIALLLDEKRTERLEYIENFLNILRGELKKYNVHFEVAGRPKHIYSIYKKMVKKKLSFDGLFDIRAVRILVDTVPECYTTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVGPEDKGVEVQIRTFDMHQFNEFGVAAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESGKEDLAAAFKTELFNDTIYVLTPHGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIVPLSTPLENGQRVEIITAKEGHPSVNWLYEGWVKSNKAIGKIRAYIRQQNADTVREEGRVQLDKQLAKLTPKPNLQELAENLGYKKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSETTIVKQSKIKKGGKNGVLIDGEDGLMTTLAKCCKPAPPDDIIGFVTRERGISVHRKTCPSFQHLAEHAPEKVLDASWAALQEGQVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQTQSRDLEASMRFTLEVKQVNDLPRVLASLGDVKGVLSVTRL
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular Localization:
Cytoplasm.
Sequence:
MASRKEGTGSASTTSTSAAGAASGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGNEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEHMFEEVPIIIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKSLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENQQRQSRGEPPLPEEDMSKLFKPLQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
The following text describes a protein:
Function:
Transcription factor that has both positive and negative roles on transcription (By similarity). Plays a role in cellular pluripotency. Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation.
Subcellular Localization:
Nucleus.
Sequence:
MALPPSGETQSQDKANYLPQSNPHHLTTYYAHAPGYSHFRNLATTEEEFQPWKLAAAVLESQAMAPLDAFRMTAPLLNPGLAVQSEPLYNLPWYKLSPWNRIPQFTPEVPRFLDSTEHRSSGSSNQNLVLGGGGGQISGQRWEAENLLLPSPVIASLLPDGIKSSQSISVPQTLNQEGKLPFCGFNFTEEELSFVLYGAIASPEHPTDLQHAISGILVPTESSGSNHLHKTLDKDSLQLPEGLCLMQTSFGDVPHFGVFCSDFIAKGVRFGPFRGRVVNASEVKAHRDNSRMWEIFEDGHLSHFIDGKGSGNWMSYVNCARFPKEQNLLAVQHQGQIFYESCRDIQRNQELLVWYGNGYEKFLGVPMNLRVTEQGGQQLSESSEESAEGYRCERCGKVFTYKYYRDKHLKYTPCVDKGDRKFPCSLCQRSFEKRDRLRIHILHVHERHRPYLCSTCGKSFSQSSSLNKHMRVHSGDRPYQCVYCTKKFTASSILRTHIRQHSGEKPFKCKHCGKAFASHAAHDSHVRRSHKDNGRSSCDICGKGFLDQEAFYAHMRLHKTC
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEVMGKAGNANVSSSRPSVVNIGALFTLNSVIGRAAKRALAAAVDDVNSDSSILKGTKLNFIIVDTNCSGFIGTMEALRLVENDVVAAIGPQSSGIAHVISHVVNELHVPLLSFGATDPTLSSLQYPYLIRTTQSDYFQMFAIADLVTYFGWREVIAVFVDDDYGRSGISVLGDALAKKRSKISYKAAFNPGATKNAINDLLVEINLMESRVYVVHVNPDSGLQIFSVAQKLGMMSKGYVWIATDWLPSVLDSTEPVDTNTMNLLQGVVALRHYTPDTDMKTRFLSRWNNLKYKDRKGPAGFNSYALFAYDSVWLAARALDAFFNEGGIVSFSDDPKLQDGNESSLNLSLLRVFNEGQQYLQTLLRMNFTGVSGQIQFDPDKNLVHPAYDIINIGGTGSRRIGYWSNHSGLSIVPPEILYGKPSNTSPSNQHLYTTIWPGENPEVPRGWVFPNNGKPLRIAVPNRASYRDFVSKDKNPPGVKGYCIDVFEAAINLLPYPVPRTYILYGDGKRNPSYNGLVDAVAQNTYDAAVGDIAVVTNRTKIVDFTQPYMESGLVVVAPVKEVKSSAWAFLKPFTVQMWCVTGAFFLLVGTVVWILEHRINHEFRGPPRQQLITVFWFSFSTMFFSHRENTASTLGRLVVIIWLFVVLIINSSYTASLTSILTVQELTSGIGGIDSLISSSEPIGVQDGSFTWNYLVQELNIAESRLVKLKNQDEYFSALKLGPKSGGVAAIVDELPYIELFLSDSNCAFRTVGQEFTKSGWGFAFQKDSPLAVDLSTAILQLSENGDLQKIHNKWLTRAECSMQINEVDSSRLSLSSFWGLFLICGLACFIALTIFFCRVLCQYRKFAVEEGQVAEVEEIQPARPRRALFSGSFKDWIDFVDRKETEIKEMLGHKSNDNKRQASPSIEEHSHA
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Sequence:
MDPQEKNKYWEIFRGLNPENGYLSGSKAAGVLRSSKLSSDKLEKIWDLADIDDDGMFDFDEFAIAMKITFDLINGVYKTVPDRVPEALVSTSKKHLVAARDALRGNDDIALLHKVPSLDTDPEDAVLKDGFDWYISPSDKIRYSDIYSLHCNKHGEVSFNGLAPVFTPFGVPNSQIQKAWKLVNPQGTETIQKDQCLVFLHILTQRSNGFRIPNDVPYSLKASFKRGNIDYNLDSYNSTNNYYSSPTMAPSTGGAKPKSDLDAPRDVRDSDWELISLRNELSKLDEKILSLQRETDDVNIAQNKSKLIQRDLQKVLDYKLGILQSLKNDGPNGPSASAIDNDLKMLEQQLNVLGRHLEGRKSQVAKLEERLRSLS
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involves the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.
Miscellaneous:
MISCELLANEOUS: Present with 1950 molecules/cell in log phase SD medium.
Sequence:
MASMFRPPESNRSHQKTPKLTLPVNLVQNAKSTNDGQHLNRSPYSSVNESPYSNNSTSATSTTSSMASNSTLLYNRSSTTTIKNRPVPPPLPPLVLTQKKDGIEYRVAGDSQLSERFSNLHVDITYKELLSSAPISTKLSNIDTTFIKKDLDTPEGEDSYPSTLLSAYDFSSSGSNSAPLSANNIISCSNLIQGKDVDQLEEEAWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWIVGQMKKKVNMERFVKKCWEKEKDGI
The following text describes a protein:
Function:
Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane.
Subcellular Localization:
Cell outer membrane.
Sequence:
MNSGLSRLGIALLAAMFAPALLAADLEKLDVAALPGDRVELKLQFDEPVAAPRGYTIEQPARIALDLPGVQNKLGTKNRELSVGNTRSVTVVEAKDRTRLIINLTALSSYTTRVEGNNLFVVVGNSPAGASVASAAPVKASPAPASYAQPIKPKPYVPAGRAIRNIDFQRGEKGEGNVVIDLSDPTLSPDIQEQGGKIRLDFAKTQLPDALRVRLDVKDFATPVQFVNASAQSDRTSITIEPSGLYDYLVYQTDNRLTVSIKPMTTEDAERRKKDNFAYTGEKLSLNFQDIDVRSVLQLIADFTDLNLVASDTVQGNITLRLQNVPWDQALDLVLKTKGLDKRKLGNVLLVAPADEIAARERQELEAQKQIAELAPLRRELIQVNYAKAADIAKLFQSVTSDGGQEGKEGGRGSITVDDRTNSIIAYQPQERLDELRRIVSQLDIPVRQVMIEARIVEANVGYDKSLGVRWGGAYHKGNWSGYGKDGNIGIKDEDGMNCGPIAGSCTFPTTGTSKSPSPFVDLGAKDATSGIGIGFITDNIILDLQLSAMEKTGNGEIVSQPKVVTSDKETAKILKGSEVPYQEASSSGATSTSFKEAALSLEVTPQITPDNRIIVEVKVTKDAPDYQNMLNGVPPINKNEVNAKILVNDGETIVIGGVFSNEQSKSVEKVPFLGELPYLGRLFRRDTVTDRKNELLVFLTPRIMNNQAIAIGR
The following text describes a protein:
Function:
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding.
Miscellaneous:
MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MVLTIYPDELVQIVSDKIASNKGKITLNQLWDISGKYFDLSDKKVKQFVLSCVILKKDIEVYCDGAITTKNVTDIIGDANHSYSVGITEDSLWTLLTGYTKKESTIGNSAFELLLEVAKSGEKGINTMDLAQVTGQDPRSVTGRIKKINHLLTSSQLIYKGHVVKQLKLKKFSHDGVDSNPYINIRDHLATIVEVVKRSKNGIRQIIDLKRELKFDKEKRLSKAFIAAIAWLDEKEYLKKVLVVSPKNPAIKIRCVKYVKDIPDSKGSPSFEYDSNSADEDSVSDSKAAFEDEDLVEGLDNFNATDLLQNQGLVMEEKEDAVKNEVLLNRFYPLQNQTYDIADKSGLKGISTMDVVNRITGKEFQRAFTKSSEYYLESVDKQKENTGGYRLFRIYDFEGKKKFFRLFTAQNFQKLTNAEDEISVPKGFDELGKSRTDLKTLNEDNFVALNNTVRFTTDSDGQDIFFWHGELKIPPNSKKTPNKNKRKRQVKNSTNASVAGNISNPKRIKLEQHVSTAQEPKSAEDSPSSNGGTVVKGKVVNFGGFSARSLRSLQRQRAILKVMNTIGGVAYLREQFYESVSKYMGSTTTLDKKTVRGDVDLMVESEKLGARTEPVSGRKIIFLPTVGEDAIQRYILKEKDSKKATFTDVIHDTEIYFFDQTEKNRFHRGKKSVERIRKFQNRQKNAKIKASDDAISKKSTSVNVSDGKIKRRDKKVSAGRTTVVVENTKEDKTVYHAGTKDGVQALIRAVVVTKSIKNEIMWDKITKLFPNNSLDNLKKKWTARRVRMGHSGWRAYVDKWKKMLVLAIKSEKISLRDVEELDLIKLLDIWTSFDEKEIKRPLFLYKNYEENRKKFTLVRDDTLTHSGNDLAMSSMIQREISSLKKTYTRKISASTKDLSKSQSDDYIRTVIRSILIESPSTTRNEIEALKNVGNESIDNVIMDMAKEKQIYLHGSKLECTDTLPDILENRGNYKDFGVAFQYRCKVNELLEAGNAIVINQEPSDISSWVLIDLISGELLNMDVIPMVRNVRPLTYTSRRFEIRTLTPPLIIYANSQTKLNTARKSAVKVPLGKPFSRLWVNGSGSIRPNIWKQVVTMVVNEIIFHPGITLSRLQSRCREVLSLHEISEICKWLLERQVLITTDFDGYWVNHNWYSIYEST
The following text describes a protein:
Function:
Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor.
Subcellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Sequence:
MKIIIFVCFILIFYLPIQKKHVNSQQQGIDSDDGDAESFFNKSYSEHQSALEQKIFRGYNPKNRPMKNASFPTIVDVHWHIIHVSINQREQTMTVHGHIYMRWFDEFLVWDPKDFNNIQYARVKKWQVWQPKIKVSNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMYPTFSIKVGCAFDFTDYPYDLNKCAINLFSTSTMADVQLQNLYAIPPTLSFGWEEQKMKRIISDFKIQNVSSSALYYTNGNITSSAPITGFDLGSTWSMLAVTVSFVRHSPLFEAAVVTPCIVVASLISMTFFIDSLSSTFLLMMLHFYVQLIFLHDLVEKLPLSVSEIPFCIKLIGILMYTNGLTLVLHSSLLCGSYYKCPVPQQLNKIFVIEEYIPNTFKEKVQIKKEESNKSWRDLMKLIRPIIGFVLIILLICMFFVCLLL
The following text describes a protein:
Function:
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRTSHSCSGLVAYGLFLLNCAILCCSQLLHQPQCDPEKEYESNGGCCSKCQPGFSMTSKCTDSKDTSCNPCGPNEYMPSWNNDYKCFSHHICDSGKALKVEFHGNSTAPRKCVCEEGYHFSHDYEFCNKNTKCIPGYGVVRPVQLNTDTICKACPVGYFSNVSSSKESCKPWTNCSKLGLFESKPGSNHYDVVCDHLNPNRQRVVIFIVLPLVITIIIFMTIYFLCCTNRLKDLKGNLEQWMTDLCHQFQEAEKKSPCNICTRTNNYRQGQQNFTPYVTVSMENDCDAAHKDPKEQRGGPGTSCVREYEVKQGRSGPIENEYLERKYAMATDGPACVSDTAESSVESETISSFYTGPDHPLHLQKDACGQSARELTGKHIVNSNYGNCSMTEPMSSMNGCCSQLSSSGFSLQTNGPPSMTSSEETDSHNDGSTPTSETPPLSGQVTGNNNTTVISNGSVMNIKADVLLLVLSPTSQDAPTTPDSNDGNMGKPVQEENQCRCDSFVANTENHVGKYTQYSDDLSKSSQNTESWTSSTDFIQGSGSPLILSQELNNICPCQNICLSPVQEEGKPE
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein. Peroxisome membrane.
Sequence:
MSAERDTEGSAGNPAVNENGPGMAPAPAPAHGLAPGGASSPEAAPEAPREKMIETAVKFLLNPQVRSSPMAQKKAFLRKKGVKDAEIELAIDRSGTRQDVAPPANQTPTAPPPQGQVPMATHPGAVPQQQMVPYMQPPSPSRVTTWRDYAAIAVIISGVSFGVYKLIMKLVSPWLKSRKEEKERMNRLEASIEELNKNVSQAVTAMEKSISTIQGLMEKQEQQLTTLNSEVVSGKALSNGRRSTDTTEIKSEIMSLKGLLLSRHQFPSTPQRTTIPSWQRSSDQSSTKSNSPPPLSTEATNGNISSSPPPPPLLSGEPVTNGDSSSADPAQTPVKVPITENGAEDAVQKDPSPTPDEPVNGSVKPIDSQATPTLEGTA
The following text describes a protein:
Function:
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.
Subcellular Localization:
Cell junction, focal adhesion. Cell membrane; Single-pass type I membrane protein.
Sequence:
MGIELLCLFFLFLGRNDHVQGGCAMGGAETCEDCLLIGPQCAWCSQENFTHPSGVGERCDTPATLLAKGCQLTFIENPVSQVEILTNKPLSVGRQKNSSDIVQIAPQKLTLKLRPGSEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSLLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDNKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNRALFPHQKKCSHIKVGDTVSTGSVNCRKYVQVSKKLSYCTEAGIFLSRISKVIFKNFLINAFGKADPHATLFSPMHFGGWKKIISIFFFQASFNVTVSIPNCERRSRHIIIKPVGLGDALEILVSPECNCDCQKEVEVNSSKCHNGNGSFQCGVCACNPGHMGPRCECGEDTLSTDSCKEAPDHPSCSGRGDCYCGQCVCHLSPYGNIYGPYCQCDDFSCVRHKGLLCGDNGVCDCGECVCRPGWAGEYCNCTTSTDSCGSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSADGQAREECVDKCKLAGATISEAEDFSKDSSVPCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKMDLSTDG
The following text describes a protein:
Function:
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Nucleus.
Sequence:
MSKTLKKKKHWLSKVQECAVSWAGPPGDLGAEIRGGAERGEFPYLGRLRDEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDVSAAVISFTSGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGGAAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDENLEPLPKNWEMAYTDTGMVYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVDEAKRKKQLGQADTGSSKPDVEKSHFTRDPSQLKGVLLRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDNEDPVVDIVAATPVINGQSLTKGETCMNTQDFKSGAMVLDQNGKSGHTLIGDRLNGLSDPSEQRASMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENSGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQPIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRRIFCGEKQLEDDSSQAFISTQNGSPRLNRAEIPARPAPQEAYDVVLQRKENEGFGFVILTSKSKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIIELSHDSIVQLIKDAGITVTLTVVADEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKPLAQPDTAMISVVGSRHNQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEEGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDMNSPSSSSVIYDEQSPFPPSPHSASMFEESHVPVIEESLMRVQICEKAEELKDTVHEKKSTLNEKQSDIKHQSLLQKNVNKRDPPNSLGHSDKRNLLKVETGIPQRGRSASPQKSASRYSEEHLEKIPSPLKNEPKTRPRDRSVSPRKGENSGQPGARAGSGQEHSRQGRGQSSSPKKQQKTEGSKDQSSAEAKLLELESRRGGGRARDRAERVWDGKEKAGVLRKDMKQSQSGKNRTRSPEEKSKRMDEKSLLAKKTDNTTSRAASENDQGRKATSGETSSSKDKIGESVKVSEKRKQEPEERMVLNKPEDHKGKELEAADKNRESGGFKPESGSPAKKTPITPGPWKVPSAHRATGTTGVAEKRL
The following text describes a protein:
Function:
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFRNYLNLPEILTQVYLNKYAILLILILIKLILLETSILDNLNSVLLDNSICDNGEIQPVLNTVHYMIVDSLQTLEAAGIVSIILTLKVIKQLALFFIELFFGTYICLLNAALKGSTEVALDASEGVIRAVNATVVSATNDIESALKGLSSIINDLVTGFNAIKNMFTGSKSDPTQYQNKINITLGDLKSKIMIPSEVLTKLDNFKNSSLYGLSQLGNGTQTIVSTPFELAIKKLNTMKSSYNFTTGAPSPINFREECLKDMSKLKDVQTDLAKLVEKISKWLFIGLVLAMVGSILYVSYIQWRHWRRMDKFISETGIDKEVQFRNQYNIYNNFLIYTIVKRMGIELNERTIWMLSFMFSKISRNVFFFGIMGVVSVVAQYILLNSVQSSMNNHIKSFDITSNSTSMSASTIYLRDMNTYIDDTQDKLNQELFSGIKEISVSLNSTIVEFLDKLNETLSDIFGSTPLAGPINTVVYCTIGRKLEKVEKGLTWMNDNLNINIPSISRDIEDGLSHMTFLQPQSVLARANKIIDLYRKSILLELYISLGLLGVWLFQIFVGSATLTIRYWNSTRQGNNSYAISSPHELSEQEKQVYGYPLSHPLIDGKDLTTSSSFYPTTEEKSK
The following text describes a protein:
Function:
D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Nucleus envelope. Nucleus, nucleoplasm. Note=Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids.
Sequence:
MDEYEDSQSPAPSYQYPKETLRKRQNSVQNSGGSVSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNISIPNVLRWLIMEKNHSGVPGSKEELDKELPVLKPYFVSDPEDAGVREAGLRVTWLGHATLMVEMDELIFLTDPMFSSRASPSQYMGPKRFRRPPCTISELPTIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPWSRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDLQTKRSVAIHWGTFALANEHYLEPPVKLNEALERYGLSCEDFFILKHGESRYLNTDDRAFEET
The following text describes a protein:
Function:
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity).
Subcellular Localization:
Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
Sequence:
MTTENGAVELGSQSLSTEQTPKAAAGDGPSASEKEPSAPATEKDLSPPNAKKDPGAPDPKNNPDPPSLKKDPAKAPGPEKKGDPVPASASSQGPSGEGDGGGGPAEGSEGPPAALPLPTATAEASIQKLDPTQAPSGNQGSGEAKAGKKAAECREAGRRGSPAFLHSPSCPAIISCSEKTLAVKPLSETTDLVFTGVSVTPDPQDPGPVKAGGTNALAEKKKEEAEKASGQAGQAKVQGDTPQRIGFQAVPSERVEVGQALCLTAREEDCFQILDDCPPPPAPFPHRIVELRTGNVNSEFSMNSKEALGGGKFGAVCTCTERATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETSHEIILFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLLTKDQSARMSAEQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
Miscellaneous:
MISCELLANEOUS: Present with 1460 molecules/cell in log phase SD medium.
Sequence:
MTSKKVILVALSGCSSSGKTTIAKLTASLFTKATLIHEDDFYKHDNEVPVDAKYNIQNWDSPEALDFKLFGKELDVIKQTGKIATKLIHNNNVDDPFTKFHIDRQVWDELKAKYDSINDDKYEVVIVDGFMIFNNTGISKKFDLKILVRAPYEVLKKRRASRKGYQTLDSFWVDPPYYFDEFVYESYRANHAQLFVNGDVEGLLDPRKSKNIKEFINDDDTPIAKPLSWVCQEILKLCKD
The following text describes a protein:
Function:
This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Sequence:
MAPHALPVSSKTTSEVDVTSSSSFSLIKANPFGLTTDPQEIKNTTYTSATTIINQTIYSIASKIFSYETVGDENLLDSNIQLWLQYQRLNAYGIVPFYNKFQVRSGAANAILGYFTKNGTNGQPVSTLLGSNGLNYMRTALSSATADKLPLALNVSAIDFNQDSLVSNYGEALNAARALSYPVFTPVDSNDALEIQHLAILNHFYSFFSGKPSVYLFDGPEFVKTFKKFENVLSTNDIFQLYQGLLDSAAGEVSIDAAFNALNKVTGKNYSQFEYVGSENPKTVFVVYGTHQSTQLSQIVSKLDVGLVKVRVPVPFNQEKLVQVIPQSTKKLVVLSSNDGLMADVTAGLFLGGRYHSLSLDEFNYPLDFKWTPVTVTKLLNEFVSLDFEKIFPVVKPADEILTANSSPEGSYLFWGKDNGIIVDTVDKLALSLSLDNSKNVAIRNTFDNGNGGGLFQSQIVSTTGPIRAVDAADVVVIEDLSLLQYYDILATAKPDASILYINQKSLTKEELIEKLPIEFKKDLAKNHNKLYAIDFSIIEKLDEANSATKGFSGEFLIQLAFWRSALPELGGFIVNKLLQANGNSFELLGTVLDNFINSVDENEGIKEIPVVPEWVDLKDEVKEAEEKKENEAEEKDKEQAEAETEAEEPKELPFFPIETSFFANPRNPIEAAEEINNTGYKSLAQKITFPEAYNVSKDLRPDLPVKNFVVKVQENKRLTPTEYSRNIFHIEFDTTGTGLTYDIGEALGIHGRNNSEAVEEFLKFYNVDGDSLVEVTNKDDSKIVEIRSARQALSETVDFLGKPPKRFYESLAEFATEEKEKAALTKLASAEGAEELKKRQEVDFDSYFDILQEFKSARPSFEELIKIIAPLKRREYSIASSQRIHPNAVHLLIVVVDWVDPKGRLRYGHCSKYLSDLKIGDELVVSVKPSVMKLPPLSTQPIVMSGLGTGLAPFKAFIEEKIWQKQQGMEIGDIYLYLGSRHKKEEYLYGELWEAYKDAGVLTHIGAAFSRDQPEKIYIQDRIRQTIEELTDAIVTKNGSFYLCGPTWPVPDITACLEDIVRNGAKKNGEEIKDVAKVVEDMKEDGRYILEVY
The following text describes a protein:
Function:
Plays a role in the establishment of normal sperm morphology during spermatogenesis. It is required for acrosome attachment to the nuclear envelope, and proper manchette elongation and disassembly.
Subcellular Localization:
Cytoplasm, cytoskeleton, perinuclear theca, calyx. Cytoplasm, cytoskeleton, perinuclear theca. Note=Localizes to the subacrosomal layer of the perinuclear theca in round and elongating spermatids. Localizes to the calyx, also known as post-acrosomal region, in spermatozoa.
Sequence:
MSIPRFLKVTYGAYDNYIPVSELSKKSWNQQYFSLAFPKPPRPGKKRRSLPSQLQNNTAPVIDEEKLGVHRPPLWMHRSLMRISERPSVYLAARKGLIPKPLHFGKGESKSVGTHKSLASEKTKKEVKMKKDGFEAKEKTALKTDKEGSPKPAKKNIPRDSQKDKGRVSSDSEGEKAGVKKGSKKVKNTPKGKDSASESEGEKAGSKKEAKTTKKGSKDKVSATESGGEKAGSKKEAKATKKGSKDKVSGTESGGEKAGSKKEAKTTKKESKDKVSATESGGEKAGSKKEAKDDKKDATSSQETLLSTAADKDGKKKEEKPVKQSSKSKDTVKDSASEKGDEKKEDKKEGKKEKKKKDGEGKEGGKKEKKDKKDKKDKKDKKDKKDKKDKKEKDKKDKKDKKDKKDKKDKKDKKDKKDKKAK