lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in microtubule-mediated transport or vesicle function.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATQEKLLKSLEVLKTLSAPNQTFDSSKKKDKIQHCHIVTEAISNSTIKIAPSFPTYLSITIEVLLQLCDDQESDVRMTAGDCLNKVIRAMNDGNIGKVQIELHKGIKQNGSARSLRAALKRFSQLAHLIRPHKGKPYVVNLFPTLIKVSQRPEEQIHETLANSLAPIMRVLGSFTSEVEIKDLLKGFLKNISHSSPVIRRSATTCVLNVCLNCRKPSIFMAYVINYLLDLLIPVSDNQSSFLILGVLACLKNLLQHLNDNQNGDNASLSVDKLLQIYELCLHYFSNKDHNVVNAALETLNVLLQNCSLELRQILLSESGVDKSRISLPTSYSMSALRSPSQLSVATSAANDDLFLESELTDTIRSDIEKWIDESKLSVMNVPCAKTNELEKSLSSESKNSSLDVSLAQLDSFDYKISEYVGKSHSVGDNLERLTISDDSSEKSYSYIEDDKNCETHFPDVAIGSFLDTDISLVYCARLITKSFLLSGQKGVCIPDKSVRVSVKSLALTCLASIVRIYPKILLLCLGKKCKSKNHLPIADLILYENHTDPQLRGVFRTLLSNFITAVLSETHSSYDKWIESNCCDGNFARLQLDSLVKFIIKGLEDESSGCARQTIISLDVCLEKIAESVNNIHVLPILNCLPLLATNPYWLVKVALCELVSKLPYVTICNITGSSDFQNRIIDDVLFNFLRNDDARVRSGAASAIVSVIPFLYHEENAVTAKAIHYKKLFLSNLCDKNTEKDLTKKHLIDNMPSPFSQILHERCDKTEYSLSRIVTKLYHFLLTGTSNHFIYGCLETLSLLSNAYPTTVYTKAWNCKIFQTEKDNSNSDVTLDLFNICVYLLSHSVICYDLTCHLNLLNLSSNLYAGYALSLIKPISESEPSTQPWDMFSSPKFSKLSDHFLSHLVKLLNIFHYVLDDVTPSQLQSKPVLPNLSTASPIKRRKSDLEKKVLSPSKTPEKEDKDKKDSKGAFLHLPHYMKFYEILRQAYTNYKITLESEACVKFSGLLTQTLHSFAVLMEVGTLVEFHAIAEDILGYFRFTFTLEASATVECVQQLLKCLFGNNLTSNIGLIREVNQAEVGEQSNGFYHNLYQKPYDGVSECFNSFKNIHKVDCDGDSTLMGYLHRRDAKPLPVRNSDKILANYIRIFEPMVIKSLKHYTITSDVRLQCRVLQLLNQLIQLRVNYCLLDSEQIFIGFVLKQFDYIEKGQILLASDLVKKIFQFLVQLSHSKQHSKSIITVPKIIHLCDGLMASEQSPLTHCIPALEPIVENIFLTRNKSNTADAKELETTRDVVLSMLLRLYEYHEVIDLVALILDDSKYCSNSEKWLRWSTQVTDAILPMLRQNKIRLDSVEALVSLRRLIFVLEPSVFQPVDSVLLLLFQEPLVYDNWQFSYTRRLAKILIGLLVLSPVKEESLIAKINELKAEFAPGSIFENCAPTADPLNVLNSVDIFREVAPEMIFVRFLFRVLNLASRFCVEVTRDGTNDFFIEEISIFLMYCIHIFQSGSHCKIAIFAISNVNVAQLEDISNNFLKVAHEYPIVVFLWSYVLTILNYNEKKFWGQVADLSPVSPSINQKILSTGSIILFCDYMNQDVLKLDQLSWFLTNYVSQIVHLCDEDPISEFISSVHRNSATSKIFIDSLMTTNLDSKDPVFVLQILKSVENTHPYHTGTLLKLLLPKLLISKELAVSRLVANLASRKIELLLTMSMAEVHEQLAKEDLLAIIKKIAALNLVRKNEALSSLLNKLCTQYYDISPLEFDQKRSVNPDYIKKLAIDKNWYLAQIREKCNSKETAQLLTRLDYEELCNFLRNADFSKVVFKECLRLGLDRNKTVEPLITATVTCLSEEVTTVCDHIQVFSVPTLEDSERFDSRFLTQIYDLIPSVTFYIDQLPETKVSDNSEVLVKFGVICLESINYLIDRKNFNLNYIDLAIHCCESVLKEKKLFGVLNQESHISWLCSIVNSLYKLVEYLLSDKGQLPAISSSVLQTTPAGEACYQMYSLVTWLYKNSDPIVPKLLFKPIKNIIVSLSRLSVVNSFVLIPTQVLKSGWTPELVGTFQTQVPPLPIEYLQEIDVLEEFIFRTTLLGWTSRQQFEETWMSLLSVLCNNFEDKDSLVVQDVVHASSLAVKAITALLVQTLYFPTPGNTNLSQLIHVSRYPNTPKSTISNEKLRKIQDTIERKYREAGYLPKIGNIFEHTNFEKRCKHYSYGQVSVKYLSIAAKIVEIDDKCPTANIWKHREELLESHGLDINSCLQFLLDYYTQQLKNQGSTPLRFLHEIVRSTVTISDLFTDKSQFSWMLEVFLELSKLHTVEDELLHQYLIVGISKATAVLTPDLETYETIKKLLTQYLKSSFLPSRMACLHGLLYLLEGCKLSNISIGGISEEMQIILPCATEYVQCNLNSNNEILKRSQEHTILVWTLGFFIVENIEETHLESNFISNVLSTAFTVLLQQKPPNNLQIILMKALERLVIFKPTLTKGISKQIMSLALEKTKTENPNVSILGLQLLLSYMYTDCSEQLEAVGSPTNPDHLVQTIEKISAIFEHIKRGYMSQVEILCHVLPDILNDFFSPADILTKVISEFLSPQQPHPQLLSKVVFRVFERAIEEKQLPLLQDWVVFSLSNFTQSLSVGMATWCLTCFFISASSNEWLRLFFPYVQTRVGRYEYEDRKMLCIAGADFYKNLTNQNQKDTFIENFRKIKEQPDTLFTDLLSSL
The following text describes a protein:
Function:
Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular Localization:
Secreted.
Sequence:
MTRFLARILFFETLTLILLQGVLMSHDDLESNPRLLRDAQEFDSRGSQLSETTKSRQKRCTCYSYTDKECVYYCHLDIIWINTPERTVPYGMSSYRGQQRSRRAARARLSEREGPKTPRCICADTDKDAECQDFCWSNLRQTPQTRNLHRVSGLGQQLRASPSDGSASPL
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm.
Sequence:
MPGKEENDTLEKSLKELNLTSDEMTKFEKAFKDPEFIKLFEEYAKEVSDPKVKAETDAYLRQIEQQGRAEDVYGAGTQLIVPDPAGAVIKTKVVSSSASKKQQQEQEKQEKEQQQQAAGAGKPEGPGKQGALPVGQKVFINICTCDKLERYSLTDAQDPATGRLRPKLTIPLSLGPVRQGADKQGAPAAVYDFVVHPDSWTFAAGNAAGLATLADTALDHVEQVGRCRLVRAWKRLNCRYKGTEGAAEPPVQCIRTSAAAAAGAAGEGAGGRVRPRPDVPGVPDLPGAKTAPPAAAGAAATAAAAAGAAEGGAGSSSRSTFSFDKSRKAGGTEAAGAVAKQEATITDPARPGYRHPDGAVTPEWGLLHRGEADLGEAWGDAGKGLAAGGRVPKELVVRVTLPDVSSAAAVDLDVGARCLALTVPNRYRLSVQLPYGVDDAKGRAKFDKARKVLEVTLPVVPPPAPPPGAAAAARAGLALIQELGGSEEAAEVKAEVEVEVADVMGRDQEAAHAKSEAGAGAGVKSPHTAAAASSGAAPAPAAASEEEEEEDKEDGGPAAGSGGDPAAAAAAAGASSGRELTENERKWRELHARQQQEEQEQQEAAEAAAAAAAAAAEPSSRSQLTGTVAQGGAAAAAESVAAAKQQVQQQPVAAAAAPTAVLRPRLNRELAMELD
The following text describes a protein:
Function:
Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Sequence:
MSLTNATPAEAASGAKTASHILATLPTSSRNAALTAIHDALLQNKEEILAANARDLELAKREAEGGRLSLSIVSRLDLGKKGKYEDMLKGILDVRDLDDPVGKVTLRTRLDDGLDLERVSCPIGVLLIIFEARPEVIANIASLAIKSGNAAILKGGKESTESFIAISTVISAALQSTEVPAAAIQLVTTRDVIPQLLALDQYIDLVIPRGSNELVKYIKENTKISVMGHADGLCSIYLENTADPAMATRVIVDAKTSYPAACNSVETLLVEQAALEKVLPQAAEALLEKGVSLRCDASSKAALTSKLPSHQAVFLQDAVDGDFDTEHLSLTLAIKTVSNLNEAISHINIHGSHHTDVILTSSSELAERFMASVDSAGVFWNTSSRMADGMRFGFGTEVGISTNKIHARGPVGLEGLMIYKYKIRGNGQLSVEYGEGEGQKRFKHENLSI
The following text describes a protein:
Function:
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T-cells and splenocytes.
Subcellular Localization:
Cytoplasm. Secreted. Note=Secreted upon LPS treatment followed by ATP-induced activation of P2rx7. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity).
Sequence:
MMAFPPQSCVHVLPPKSIQMWEPNHNTMHGSSQSPRNYRVHDSQQMVWVLTGNTLTAVPASNNVKPVILSLIACRDTEFQDVKKGNLVFLGIKNRNLCFCCVEMEGKPTLQLKEVDIMNLYKERKAQKAFLFYHGIEGSTSVFQSVLYPGWFIATSSIERQTIILTHQRGKLVNTNFYIESEK
The following text describes a protein:
Function:
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
Subcellular Localization:
Nucleus.
Sequence:
MDLGKDQSHLKHHQTPDPHQEENHSPEVIGTWSLRNRELLRKRKAEVHEKETSQWLFGEQKKRKQQRTGKGNRRGRKRQQNTELKVEPQPQIEKEIVEKALAPIEKKTEPPGSITKVFPSVASPQKVVPEEHFSEICQESNIYQENFSEYQEIAVQNHSSETCQHVSEPEDLSPKMYQEISVLQDNSSKICQDMKEPEDNSPNTCQVISVIQDHPFKMYQDMAKREDLAPKMCQEAAVPKILPCPTSEDTADLAGCSLQAYPKPDVPKGYILDTDQNPAEPEEYNETDQGIAETEGLFPKIQEIAEPKDLSTKTHQESAEPKYLPHKTCNEIIVPKAPSHKTIQETPHSEDYSIEINQETPGSEKYSPETYQEIPGLEEYSPEIYQETSQLEEYSPEIYQETPGPEDLSTETYKNKDVPKECFPEPHQETGGPQGQDPKAHQEDAKDAYTFPQEMKEKPKEEPGIPAILNESHPENDVYSYVLF
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Sequence:
MAGQISPTRSALLASKASLKTANGGADLLKRKRDALIGEFFALVKDALAAREQLSSVSKGAYTSLFGAKAWDSPEAVESLSLAGTGDYAVDMQIESIYGVKVPKINIPERAAQADFSPINVGARTIQASNDFGGVLEAIVKVAATETKLRRIGEEIKKTSRRVNALEQVVIPGIHDDIRFIRSVLDQREREAGYTQKKIKAKIEGKNKEAREAAAATSHGSAAD
The following text describes a protein:
Function:
Plays a role as a transcriptional antitermination factor that allows the virus to initiate its lytic phase. Activates expression of the delayed viral early genes by modifying host RNA polymerase (RNAP) into a form that is resistant to termination signals. This antitermination function requires the host NusA protein which serves to stabilize the interaction between antitermination protein N and host RNA polymerase.
Sequence:
MDAQTRRRERRAEKQAQWKAANPLLVGVSAKPVNRPILSLNRKPKSRVESALNPIDLTVLAEYHKQIESNLQRIERKNQRTWYSKPGERGITCSGRQKIKGKSIPLI
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase activity.
Subcellular Localization:
Plastid, chloroplast outer membrane; Multi-pass membrane protein.
Sequence:
MSSPERALLNLLTDIALSFDGAILGLTLAVSAVGSALKYASTNAALKKIKDAPEVSISDLRSLLPASEDKSETNDNRKSNDQRIVVVRGVVKPKISGDEGYKNNNVLISPETGDKALIIQRTQTYVYSGWKRLFQSTGHRFMLERSLRKHGADFTRTVPFVIVGKDQQSNSSFVAVNMDGSRQPLPLTTVYNRLQPINSSFLQAFLYPDYPVGLLDIEKILPPGKDITAVGIYSFNNGVPEIKSCQDLPYFLSEMTKDKMIEDLMEQTNFIFLGSVILGIVSVGILSYAAVRTWNKWKQWNHQRELPQRPNDSVVDDEPEDADEIPDGELCVICVSRRRVPAFIPCGHVVCCRRCASTVERELNPKCPVCLQSIRGSMRVYYS
The following text describes a protein:
Function:
Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis.
Sequence:
MSDKPATPTKHALEDEDEFEDFPVDSWPSTETLKAYKEGDSCLWEEDWDDVEVEDDFTKELKKELESNK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MSFRGGGGSGGRSTQRTILPFGLDYADIISSTQETEKPQLLLPINGDITEIESIIAKQSMNFTKLMSEGPFFTGNLDSIEITKKRNHNDSENEEEEEEGGGDTENTGDRKKKKSKTNGDGSSSGSGSGSASGDGIERYSDRYKKIQKIGRTIDEHPYQPEYFPSELYSVMGITNKHDKKKFLLLSKFKSNGGLKQILSNEKLENLDEQSKLNSMKEKMLSMIDNSVNVNDDDNNNDGKTRSGDEQEIDEDDLDDEFEDEDDDDYNAEKYFDDGDDDDGGDDGGDDEAAF
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase catalytic subunit. It is tethered to replicating DNA by the beta sliding clamp (dnaN), which confers extremely high processivity to the catalytic subunit, copying a 5.4 kb genome in 11 seconds, a speed of at least 500 nucleotides/second at 30 degrees Celsius.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGAGIKPIVGADFNVQCDLLGDELTHLTVLAANNTGYQNLTLLISKAYQRGYGAAGPIIDRDWLIELNEGLILLSGGRMGDVGRSLLRGNSALVDECVAFYEEHFPDRYFLELIRTGRPDEESYLHAAVELAEARGLPVVATNDVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMRSEEEMCELFADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGLEERLAFLFPDEEERLKRRPEYDERLETELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDQVIEHVADMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLAKAFEAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQFDKSDVEYAGLVKFDFLGLRTLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREEISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEMAKQRSVFAEGAEKNGINAELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTEKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNKGGYFRELFDLCARTDTKKLNRRVLEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYASCQPWPEQVVLDGERETLGLYLTGHPINQYLKEIERYVGGVRLKDMHPTERGKVITAAGLVVAARVMVTKRGNRIGICTLDDRSGRLEVMLFTDALDKYQQLLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQRADARARLRFGATWRVSPSDRLLNDLRGLIGSEQVELEFD
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKSSLQCVKCSNPSTIAGSEGKNVAYCDGCYREMLTHKFRSALGKKRVFKDGAAKEALVVSDGSPSSVFLLGQIIDALQLNPHQKLVMLPTIVTIVSSLTSGVMASVSEDEGHVVHLSAVIRPPEEKVIAKGRDAEEEIRIFSQLLSSCKSLTAKDEIVRVLKERLILRLAAELDLSTVLISDTADDLARLSLSALCIGRGGQISEMTAGVEKRKGLPTIVRPLKEVRSKEIAIGNRMFGWEKNVIYVEENEMKRQVGYSIHKATEDFVKTLHTEGFQATVSTVLSTSSKVHPDVNPSSALCTLCQRTYSKELVGMCPPCQSIMDEIPDWSRIAHLVQMDKGWYNLPPELLLEIFSHLPTAALVHVTAVCTWWRSVARDDSLWREIFMNEFHSFVSTAPVCDVLADEYGMIKRGCPTTIAEVVEDFYYELENVVFSPLGCFYAVSGKDAMLCVYESTSRQLLEERDLHLSLRWTGIVALAFSPDDMCLAVRGVKANGKEEVATFEICIVECCLHFISRLPSTKCSPWFNNKWILSNDVYPMDLKGEGYGSFSSQYVKSISHLQLYKRHSSKKEARLEPKTISLMKLLNESEDPFNFLVSPFVSRRFRRIIDMAREAAWEGKAKTQMDKLKQLLDKDERCFKCYITDGCEEECTCSCHVGRDDFMLIYGRHEDEIQSRICFHIVDLKKAIDDDEKKEREQKEGEKPRVEDPTPDDDLYSYLSRQTSAPDHEIILDGRLLHLALSPDYKYLYATVNMSPRSSSPLTEIRSFHLQTMVAERGIFYGGLAPFPNTTIPTAANEYFLFSSTDEQVVVWSRVHHGPSLTRLTHPNPVRSIAAHPQEKLLLVVVGEQLHVWTPAFAS
The following text describes a protein:
Function:
Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
Subcellular Localization:
Cell projection, dendrite. Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MEEIREGTKRLSSREVSRLQEEHGKVVSNCQEKIQNWRKVESDYDALQERLSTLPDKLSYEILVPFGPLAFMPGRLVQTNEVTVLLGDSWFAKCSSKQAVGLIDHRKKHVRKTIEDFQEVAKNFASKEVFTKDLQRMSDEPGDFFDIREEANDETACTKAGSQQRIAHKPHSKPKVHDCFEEEVAEDEMEKKAKNTFLDNEELWARLEELEQEEELHGELNDFSEIQNGIKDLSFFEEDKENRKTDLNVSQEVRESPAQGNYLNTKSESAVNTSGVHVSGPHHSDGEDDFSKNSVATIHFLHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKNSNGNGQSVLELPTIKTPADVYRVFVDVVNGEYIPRKSIMKSRSRENSVCSDTSESSAQEFDERRNYLRNVSFEENAFSDHSDGFHEEEDCVQKKLSPVNGPLEAFSGTVVEKEPLFVPFTSIAHPALPTIQEKKAEEQTTEVSEESLKRVSKFKSARIQQNK
The following text describes a protein:
Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLFRIGIILSLFLLLTPIPCQSAVSSIDLGSEWFKVAVVNLKPGQPPIAIAINEMSKRKTPSLVAFHAGSRLIGEEASGIVARYPNKVYSHLRDLISKTFPHVSKTLESLYLSYDISPEESRNVAVFRTENGDFTSEELVAMLLKYALGLAEAHTRGTPVKDAVVTVPPYMGVAERKGLLVAAELAGINVLALVNEHSGAALQYGIDKDFSNGSRHVIFYDMGAGSTYAALVYFSAYNTKEFGKTVSANQFQVKDVRWDAELGGEHMELRLVEYFADEFNKQLGNGVDIRKSPKAMAKLKKQVKRTKEILSANTAAPISVESIYDDRDFRSSITREKFEELCEDLWEKALVPLKEVLTHSGLKVEDIYAVELIGGATRVPKLQAKLQEFLGRKELDRHLDSDEAIALGASLHAANISDGIKLNRKLGMIDGSPYGYVIEVDGPDLPKDESTKQLIIPRMKKLPSKMFRSIVHNKDFEVSLAYESDDFLPPGTPSLTFAQYAVSGLADASEKYASRNLSAPVKANLHFSLSRSGIFSLDRADAVIEITEWVEVPRKNLTVDNSTSASANTSTESSPSNTEESSENLNADGGNSNTSDPSANDSSTTSLSTEKKLKKRTFRVPLKIEEKTAGPGASLSKESFSEAKSKLEALDKKDEERRRTAELKNSLEGYIYDTRDKLESEDFTKVSTSQERQSFIEKLDEVQEWLYTDGEDASATQFQKRLDELKAFGDPIFFRHNELTARPAASDHARKYLNEVQQIVHGWETNKSWLPKGRIDEVLKEAEKVKNWLNQKVAEQKDTPGFNKPAFTSEEVYEKVLDLQDKVTKVNRIPKPKPKIEKPVKNETESSREKADATNFSSEEGTSQKEKTASDAEKPSTNGKADAQSKDHESDHDEL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MKRVREYGDWSFATLDMVTKVKNKKVKVTHSSPLLPPALEEKPTLVLDMDETLIHAHKATASLKLFSGKILPLQRYLVAKRPGVDTFLNEMSQIYEIVVFTRAVKPYADRILDRLDPSWESLHPSPLQRFMLAQGSGREKGCERSFKPSNGIVIRAFKNRKGHKYDELKKISNLLKEIARVEDVRQALEKLRG
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MATHSSTDSQAPSYPSRKQLPIYDEPSQEIILVKTELPLQAQVRWARQNIQSFKKDLESRFNFVLDHGLNIEKKVAGTLGSLIDQKESSSSSVLCVGIGTMTGSILARNRSFPLRFLSPLAFFILSSNQFLPTTTQNVKSYLFKLQDHHFPQSAARRDEVIKRGAESVEWLNGLRQRMFLKTTEVVKDGSQVFEKYSGLKISHDSSPAKNKTE
The following text describes a protein:
Function:
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MEFPPLWLCLGFHFLIVEWRSGPGTATAASQGGCKVVDGVADCRGLNLASVPSSLPPHSRMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCPQMVPVDWEGPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGVLNGSISPLWAVAPTLQVLSLRDVGLGSGAAEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQQHFKTVADLSMVTCNLSSKIVRVVELPEGLPQGCKWEQVDTGLFYLVLILPSCLTLLVACTVVFLTFKKPLLQVIKSRCHWSSIY
The following text describes a protein:
Function:
Has a weak caseinolytic activity.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MLTTESPTTTTTTTTTTTSSPSSDIRDKFIFGNLEVKVKEVKGCQLHFLNVKCELALKKTEIKTKPLANHTFFDVFSFRVSAATSELEIEAWKKNFLFKDKMTGSLTIPINDLLHANGEAKWYPLSNKKPRSSRVKKENITNSNNKDNNTASPSSPDEAQEKGDEDQHHSADESPAEETSPTTGRPRSVSMPAKKVKAAPEICLEIKFVLNEPPKEVLKGIVLDGVWNSENNFGSLINNPHWIKCTQYLLSIKDEITPITLKLRQPEGTDQRCSFFVINYDPFYNGSKKVILDTTNDIKKVSSFNSPIPATSVDCKIDLEPGQYCIIPYAESFAFSGTYKFNLDSEKLDNCEFYALPKSQEQAWNEITVDGLWTTATNGGGDINILGWTKNPQYSFTLTKKSRACVLLSQDDNDKSVGFYVIKQLDAGKRAIEFREQVGKTESFKFSCSTGCTLTLDEGTYIVIPSTYDHGIEGAFHLTLFTDDKNATFQPLTNAFQEVEQVKGTWVGKSAGGSPNQPTFFNNPQFHLKVPASDKDEVIAVQLIQDSTIADEGIGFIVLSRDSHSEPLTAQDFQNEMVFTKTSNWEKRNDIVCRLHVKPESPREFTIIPSTFDPSVNRSFKLQVYSDVSISLDEIEQKDESSDSEQNDD
The following text describes a protein:
Function:
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
Sequence:
MPDASLGHGGETNKAFLILIKPVLGADTDLQRLSSSAMAPSRKFFVGRNWKMNGRKKCLGELIGTQNAVTVSADTKVICALATAYNELARQKLAPKIAVAPQNCYKVTNGAFTGEISPGMVKDLGVTRRVFGESDEKVAHALAERLGVIACIGEKLDEREAGITEKVVFEKTKVIADNVKDWSKVILAYDPVWATGTGKTATPQQAQEVHKKLRGWLKSNISDAVAQSTGIIYGGCVTKATCKELASQPDVAAFLMSGVSLKPEFVDIINAKQ
The following text describes a protein:
Function:
Required to supply glycerol-3-phosphate in the chloroplast for the synthesis of glycerolipids. Required for activation of systemic acquired resistance (SAR). Provision of glycerol-3-phosphate may be involved in generating lipid signals necessary for mediating defense responses and SAR.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAASVQPACLDLHFSGKHPPLLKHNAIIVRCVSSPNVIPEADSISGPPDIINTNRDQRKVVRIAWEKLVRWSRSLRAKAKTDVLERTRKVVVLGGGSFGTAMAAHVARRKEGLEVNMLVRDSFVCQSINENHHNCKYFPEHKLPENVIATTDAKAALLDADYCLHAVPVQFSSSFLEGIADYVDPGLPFISLSKGLELNTLRMMSQIIPIALKNPRQPFVALSGPSFALELMNNLPTAMVVASKDKKLANAVQQLLASSYLRINTSSDVTGVEIAGALKNVLAIAAGIVDGMNLGNNSMAALVSQGCSEIRWLATKMGAKPTTITGLSGTGDIMLTCFVNLSRNRTVGVRLGSGETLDDILTSMNQVAEGVATAGAVIALAQKYNVKLPVLTAVAKIIDNELTPTKAVLELMNLPQIEEV
The following text describes a protein:
Function:
Required during early embryo development, for the endosperm formation.
Subcellular Localization:
Nucleus.
Sequence:
MNKDEVFLRQWFEILYSLTNPEANSDLRRINNEKGVEKVGQKRSAESRREGKKKRVKTQCVIKSSDKSDHDTLLKKKRRERIRRQLETLKEITPNCPQSDINAILDCVIEYTNNLRLAHYKGSQGICDDWRLFTEAGAVLYYIDT
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MFPSFFSYVERIAAIFAIIGNLVLICLVMKKSVSKFGNYRYLMVYISVYEILFAILHGLTVPVLVTTDCWNFLVMRVDKTCFFQISKPFLQFLNVLFCNMFGMSMSLFANHFIYRYMVLSRSKALRDSDGRTIIFMVLFSIVFGVVWGLLAWDTMQPFPEADQMVNERFAIPMGLSLDQIAYVGVLFYTKDANGNSLVHWPSVVGIGIQSVFIGISITTILIFGFKCYQETHKISMNASQSKAKIQSELFYALVFQTLIPICLIHIPASIVYAVAAMDQSNEYYGQFLSISVCLYPALDPLPNFFIIKDYKKAIRSE
The following text describes a protein:
Function:
May be involved in splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAKRHKHYENRGSSGRGRRGGRAGHRGRGGRRRYAERNNSERAAPVWAGSGDLGNPEMVDDYYFGRQADRRLWKKDSMRMGGFRPGDMGASEQPQSHLPARKRPVTFTLARDVYDPSHNLNQLLNKQLDEGAEEEDSNSSSPSASGDDEPEGEYEPNPEPKMYRISELNDDALFFVDEQGKLPTKIPAVEVAQQETPRSVEFNDTLTVGKVQLQLRQDSNGGTFVDAPHAKRIFRDDLYGDVSEEEDEPETPKTEQLDNSKSVRTMQPPSPVPQLLSTNIGRLTLSELASESESDTEKPTAEAGAEPPKGEPGFGFLDEDHLADMSEIQVTNIRLGAAAHSYFVASPRTFGDSVARWVDHDTMVDIALELGLPEGRLHAYLRHVYEQLVPPEEPADDGADDHYGDENYDDSEEDEQDDEYENDGLIALVEHTLANDPYRNRDYNTKSLEYRGHGSRKRLIIDKESMIDETVRTLLEDKAAQRSAKRAAKRHAKEDYIAEEARMSSDLFRKYPYGFHIENIIDELEAFLVSPRAALEFPPLDPHGRRTLKNLACAFALICKQVGQSTHTRVLVQKGGRYEPDYDAVNRIRRQRRVFMRVDVRRPRDDITPREPRAKFHVREGAIVGGDAPTIGQDNVGRRLLEKLGWTHGEGLGVHGNKGISEPLMARVKKNRSGLRYTE
The following text describes a protein:
Function:
Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAWPCVTRACCIARFGNLQDKGDIAVPLMYSKYSEVTDGAQPPPPRPGSAAIETQPSLSDPYSGSLGRFSKKPESARGSVMRQDYQAWKANPEPSCKPRIEYQPSEAPLERETQYKKDFRSWPIPRQGDHPWIPKLSPSPTMPVIASDDKRKKDFVAPKAPPAEIKLINAEQPESAKGRGPTAFIAAPEILISVVQETNEIQKRESFMPKLPAKEPRATRDTGSPHPAQARGERGAGTSYRNEFRPWTDVKPVKPIKAKSQYQPPEEKVVHETSYKATFKGESNQPAAGDNKLMERRRIRSLYSEPSKESSKVEKPSVQTSKPKKTSTSHKPVKKAKEKIMASGRASKKKGAESSSTTKPEEKEKSKEINNKLAEAKE
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAQACKTTYSSRLKTGNTCLIQKNVAVSTRSHSSYTGRNSLRNVPAVNYAAFEQGEDFETPVETPEKEEEKFETDDRGLAVGRPTGNNIYPRFATKTRHIYVTDEQLKCAAEERDVYIPIRLDIELPNNYRLKDTFLWNMNEQVMTPDVFAQILCADLDLSTNVYGTQISSSIRAQIEEYAPVAEVPMPKGQEMLVVFNIQVQLAQLSYNDQVEWNLTSPLTPEEFSVLTCNDLGLSGESRPEIAYAIHECLLKLKKNACEGDLPDYDSDAVPGTKAGPRQDMDTLGALWQPVLETVSLEDAKKNENNRENLVKQWRREASKFGGFAADVSAERWRAAALGNLSQSETANLPSASVSDAQTLLEQERPRWRCRWCNVLGTGTFCVRRGPEGNKSLCNACGVAYAKTGQLPYWRKSLYT