lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play a role in meiosis.
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=In the testis, localizes to primary spermatocyte nuclei and Sertoli cell cytoplasm. Colocalizes with the synaptonemal complex in primary spermatocytes. In the ovary, expressed in follicle cell nuclei and diffusely dispersed in the granular cell cytoplasm.
Sequence:
MAAWGKKHAGKDPVRDECEERNRFTETREEDVTDEHGEREPFAETDEHTGANTKKPEDTAEDLTAKRKRMKMDKTCSKTKNKSKHALRKKQLKRQKRDYIHSLKLLNVLEEYITDEQKEEEEEEGEEEELIRIFQEQQKKWQQYRSVRRERLKEMKLLRDQFVKALEDFEDLCDRVFSDEDSELDN
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular Localization:
Nucleus.
Sequence:
MAGIEQEEGIIIEEKKQDSRMNFADEIIIDEQHILTISAEKMFEEPQKRTRKSRWGGRPDRKCARPEQKHLQFNPLEAMMNRKCILPVGAQSLAPPVPIGMALPWGMQQMPVMPVMSQSYGYNFVRTDTSHTRWGPDYEKTFQPPSLNCIPPDLSIDDLEYIIRLYCLDDINQKLQQPIDSKMDDPDLRSPSPEPVYDQHGKRVNTREVRRKENFQRIKCSLTEECIKINKNFVPPHDFKPLKKSQKIYLTDTLNAPDTNYIGLILGPGGNTQKFLEGKTGCKISVRGKGSSNTKKVDWDMDDKLHVLIQADNDEQLQQGVIEIEKILSGNQEDEQARNARLQGQVIATVLRDDFCEYCHEKGHRTYACPTKIPFEKARVKCEICHEFSHPTSDCPQKFEHKESFIQQQYDKYRKDLGLEKNTEILQQDSQNEKRTTEQRVAFITNAQIVKPIQNLQIEDDKFVMERLRREQQERENYEKAQKKALEQYTLQSQENQNK
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MNFEEMMKELEEIVNRLENEDLPLEESIKLFERGVELYRKCKEILQQNRLKIIDVMKELEGEIDASGRDQENELR
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. IliC catalyzes the ring expansion of the tetramate intermediate to the acyclic 2-pyridone intermediate that contains the trans bis-diene chain. The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain. The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone. The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H. 8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (Probable).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MITNDLIAQHSLTLTIASSVLLVFLLSRLLRKDATGKAQGCRPVAKRWQWDPILGLDIVLAQIGALKGNYYLPWLIELHSNMPKTFEINFFGKRQIYTSEPDNLKAMTATNFHDFGIEPMRRHTKGSMPFADKGISTVDGKEWEFSRFLLKPFFYREVYTSTDRIEPFADHMMALIPGDGESFNMQSLIQRWFLDLTTNFIFGKPMDALENPDRARITWAMLDVLKGGRLRAQFYMMMWAFNWTWWYKAVAEVHDFINVHIRETYKEIEEREQRIKDGKPVEPERTDLIWYMAWNLRDEELLRSQLCLVFVPNNDTTSIFISNCIWHLARHPEAWEKLRQEVLAHGDAPLTFEALRNMKYLQCVLNETHRLTPNNVTQIRVCLNDSVLPVGGGKNAKEPFFVRKGDVVSITKTVMYRDPEIWGNDAEEFKPERFDGRRVFWEFLPFGGGPRRCPAQMMVQTEAAYMLARLARVYRRIEARDPAPYTAVMRIGPSNKTGVQIAVYK
The following text describes a protein:
Function:
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. Role in the regulation of growth and neuromuscular control of movement. Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1.
Subcellular Localization:
Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation. On activation, the protein may migrate back to the cytoplasm (By similarity).
Domain:
The PH domain inhibits PKD catalytic activity in the absence of DAG, either by direct steric occlusion or distortion of the PKD catalytic cleft.
Sequence:
MDTSGSTTDFGDHVVLRYGGTKEMVPLIRHEQMLDMLMERARQIVQGFGSLDTRNMYLFRHEYNSPTLLFPITSPSQIASFSKNPGCILEIILVDRTETAVIPHVVEPESYMLPTFCDFCGELLTGLLRQGVKCKNCNRNFHKRVRMQQGIIVEHLDPLPQDRGLLDRPCYPHCHQRLLEFRCPRCQRLLVSLPHTLIEHSYRQFTVCKVCDHLLVGLMKQGLKCRDCGVNVHRKCAMELPSNCILSENAISRVNFADSEAEQASSSDNIPLFRLPDDIKIKKKFKKKFLHREKRIEKYVFSRPPGQVGVRATEKKNLEGWMIHFILSDPERRLKHYWMMQNNAIHLYNEYSEGIGVNPNRVYRIIPLAEITSVVQNNGKSVLAKHPPHCFEIRTTTNTVFCVGEDYHAFSGGPPKKIPRSMSVRPTSNTTMWFQFIKESLQPPSRNNEENAEQALEFANLYQVLSDKTLGSGQFGTVYSAIQRHSGKEVAVKVISKERFSKKGSGAESMRAEVAILQQTCHPGIVCLEFMCETKDKIFVVMEKMNGDMLEMILSQELGRLNSRATKFLLVQILCALKYLHDQGIAHCDLKPENVLLSDMGSNFPQTKICDFGYARFIPESQFRKTVVGTPAYLPPEVLQRKGYNKSLDMWSVGVIIYVTLSGTFPFNEGEEVSISEQIQNASFMFPTEPWSEVEPLAVDLIQKLLKVEIEARMSIEKCLEHGWLKGEQLYRDLRDLEVRLNTPRYLTSPQDDVLYGPLR
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
QPLFQPLNFLLCDKHNTHSTCPSEHSETKARTELTHGDVDVVIAALGLRVNREGDECSLVEDEALVLLEEKQASWEELEEAFSVFDGDGDGFISPLELQSVMRRLGLQHDAGHEECERMLKVFDRDGDGMINFDEFKLLYYWKRSKRAGKN
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MMSSMALSSTSLCSSFISQHPKLSITASPPLFHTQTTKPISVKRKIITLAAPETLTAETVTGIDTSDNTPQQTIKVVKPDEKSRVVLKFVWMEKNIGLGLDQHVPGHGTIPLSPYFFWPRKDAWEELKSTLEAKPWISQKKMIILLNQATDIINLWQQSGGNLTSQ
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MTIIQSLLILLWKIGKCFIHPRLINLPIQPQPQLWDMLLAATGTIQIMSASNLNLKALGIRDKANNILAYNWHYMSWCNLCLHISRLHTFHVVRIFQINAVLDILDIPGVNSMATSNKTEVTCAYFLQTKKRYCRMSVKTGRKFCGEHASLEAANQACPTSAAKYARTPCPYDPNHSCFVSQLAKHMEKCNSKPQPLPEYIKENVNVIDSNDEEIKVNLGTLTDDELLAIISRVSKIHSDFVGELPISVGRHPVLETTLASLTESRGSWRHVFQSSSILHNMAQVGVLTSGKSRSTYVEFGSGRGQLSYAVGQAVDLDTDALLMIDKSSPRHKHDNRYKVDGESHASIHRVRADIADVDLGQVPLVRNDTRRLVGIGKHLCGAATDLALNCLYRANNPVGLVQGVCIALCCHHQCTWGLYVGKAFFQELGLSQTDFAIMRAMTSWAVCGSRRAKEHSDAGQEAGEVTSALPGRYAAMGLDIERREKIGRQCKQIIDRGRVAFLSTWPLEAKLLYYVEPDISPENVLLLAHIS
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVPTTESHENNMPDNAAITQQQQDATTSSSSSVATQPPQSQIPPQPQYQYQMAPPPQTHHVHPHHVHPHHQQHPGYVPSHHHHHQQHHHHHPHHVGVPNLHHSIHQQQHPGYVPSHHHHQQQHHHHQHQHQHHQHQHHQHQHHQHHQHHQHHHTSPMGAGAGAAGMPILSMSPIGAYQPPHQLTSLYVGDLAADVNEIILNELFSKVGRNAIASIHVCRDSNTLRSLGYAYVNFFNNHDAERALDTLNYTLVHGKPCRIMWSYRDPTKRKTNVGNIFVKNLEKGVDNAMLYDTFSSFGNILSCKVEFEKGISKGYGYVHFETNDSAEKAIEKVNGTLILGKPINVERFVSKVERYKVENKVFFRNADESITIEILQQELSNRFGEIESCILKNDANGKSKGLGLVEFKNQEDAQKILTESGALIISTIDGTTTVSSNGGTIEINGKPITIDRIKSKVERFTEYRKKTTDLSLFINNIDESIDRDLIKEEFAKHGTIIGIKIVQDENARNKGFGFISFSEIQEAQKALDSLNGFTFGSKQIQVSFSNKDNNQINNKLNGNSTKITKNIIQGGASASQYTGYLPINRYQQHLPHQHINPMYTQQPYFPQQQQSSSSSQPSSSQPQPSSPSHLNGNTTTTSPNTRYSKTLNGTTPFKKSNLPQNANGTNNNNNNNNTNINKSNNTTQSNGFRNKRVPNGKPRYNNNNNSSNNNNNNNTTTNVTTTPSSTETTTPKTTITLEFITNATAEEATETLGSEVYNLVLAKYNNNIELAAKIAGMIVDAVPEHKELFEIISNGQIQSKIEEAKSLLDQPDQE
The following text describes a protein:
Function:
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Sequence:
MSRIVSIEGRAMPLPGHDIDTDRIIPARFLRCVTFDGLGEAVFADDRRQSGQHPFDAPHHQGARILVVGRNFGCGSSREHAPQALAKWGIRAIVGESYAEIFFGNCVAIGLPCATARQAHIEHLHTAVAEDPQIPLTLDLEALEVRLPQSRVPVEMPAGAHRMFLAGTWDATGQLRAGLAAIREIAGRLPYVDWGSPPGSSLGKAG
The following text describes a protein:
Function:
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Sequence:
MDRLRQRADFLAVANGARVNSPAFVLQSRPRDDSGPIRIGFTVTKKNGNAPERNRIRRRLRELVKRLEPVLMQPHHDYVLVGRRDALSRPFATMLDDLRIAFSKPARHTAKEQSKGRGQRPGTAPAASRKTD
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Miscellaneous:
MISCELLANEOUS: Present with 2688 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MAADRDNFLQNIENDSINNGQAMDLSPNRSSSESDSSILMNVNDIKTLRLDVAPEAKSTQSKKSLFYENSDDAEEGEIEERTNKEEGQYHHKGSKQLRFEVGKESTGKLQSHLSDGSATSGEGNVRPWEFRKVIQAEYRERLPRNYELKHWKKPSKIMIGSILRLLETNTVSALDSVFEKYEKEMNQMTHGDNNEVKRIYSKKERLLEIILTKIKKKLRQAKFPSRISERDLDIEYIYSKRQFIQNRYSQELQNNERLEAILSREQNLLEETRKLCMNLKTNNKKRLTEKLIQKDLHPVLNKAMEYTYGLESTNGFMHPDGPVTFRNDSHELNLMLNDPIKSTADVRLDKEEVLSLLPSLKEYTKKSKELKETMGQMISDSHEEEIKEVFVPHHESHQDKTEEDIH
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MRVVTSRWAGHQDGEEPGHDTAAEAHRAAAEAHGVPEDVEPDFSRAVLRALGTGVVTLGPTARITSVNPWAEHLLGRSEQEMLGRDAHDLLHRYADGSPVPRERCALRRPLHGAPAEEGSDEYFQRADGTTVPVIWATTPLVRGGRQEGLVLVFHDFSLHRSAAEETEARTTALEALTAQLHLVAEISTVLVPTERTSTTLRRLVRLLVPELGQWAAVDVYPGQSDLLERVAVRSSTRPDRARALRGPMASLPDQARAALTLLINGDRPVPLKADDLFRDPEHPLAATHRVLFERLGGHAAVAIPLRTRQRSYGVLTVGRAGDRPAHTEAEVALLADIGRRVGLVLDNARLYHEQRNVAETMQRQLLTPLPQVDHLRMAARYWPAESAMEVGGDWYDAFLLGDGVMALVIGDVVGHDLQAAAHMAEVRNMLRALAWDHQEPPSVIMRRLDEAVTNTSDAPMATLVFARVEGAEGGPWRLHWVNAGHPPPLLITRDGGTRFLEGGHGPLIGMSATLRLGLNWPDTREELPPESILLLYTDGLVESRDRPIDVGMDQLRHHAGVLARRVDRWSVDDFCDELLARIAPRGDDVALLALRLPAAGMGAPGDTEPPPPPQSGQSEAAPDRAAPGSLRQEAEVRDPTHVDPED
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MNFYSINLVKAHLINYPCPLNINFLWNYGFLLGIIFFIQIITGVFLASRYTPDVSYAYYSIQHILRELWSGWCFRYMHATGASLVFLLTYLHILRGLNYSYMYLPLSWISGLILFMIFIVTAFVGYVLPWGQMSYWGATVITNLLSSIPVAVIWICGGYTVSDPTIKRFFVLHFILPFIGLCIVFIHIFFLHLHGSTNPLGYDTALKIPFYPNLLSLDVKGFNNVIILFLIQSLFGIIPLSHPDNAIVVNTYVTPSQIVPEWYFLPFYAMLKTVPSKPAGLVIVLLSLQLLFLLAEQRSLTTIIQFKMIFGARDYSVPIIWFMCAFYALLWIGCQLPQDIFILYGRLFIVLFFCSGLFVLVHYRRTHYDYSSQANI
The following text describes a protein:
Function:
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDPLSELQDDLTLDDTSQALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPEPVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKSPGQDPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVEVTQQVLQTLPEENYQVLHFLTAFLVQISAHCDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSTDAQGV
The following text describes a protein:
Function:
Fatty acid desaturase that introduces a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Delta(7) double bond, resulting in the production of delta-4 desaturated fatty acid docosahexanoic acid (DHA). Mediates desaturation of 22:5n-3 and 22:4n-6 into 22:6n-3 and 22:5n-6 respectively.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
The cytochrome b5 heme-binding domain acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
Sequence:
MPPSAASEGGVAELRAAEVASYTRKAVDERPDLTIVGDAVYDAKAFRDEHPGGAHFVSLFGGRDATEAFMEYHRRAWPKARMSKFFVGSLDASEKPTQADSAYLRLCAEVNALLPKGSGGFAPPSYWLKAAALVVAAVSIEGYMLLRGKTLLLSVFLGLVFAWIGLNIQHDANHGALSRHSVINYCLGYAQDWIGGNMVLWLQEHVVMHHLHTNDVDADPDQKAHGVLRLKPTDGWMPWHALQQLYILPGEAMYAFKLLFLDALELLAWRWEGEKISPLARALFAPAVACKLGFWARFVALPLWLQPTVHTALCICATVCTGSFYLAFFFFISHNFDGVGSVGPKGSLPRSATFVQRQVETSSNVGGYWLGVLNGGLNFQIEHHLFPRLHHSYYAQIAPVVRTHIEKLGFKYRHFPTVGSNLSSMLQHMGKMGTRPGAEKGGKAE
The following text describes a protein:
Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MARVRVGARLGLGLGLGLVLLLLLQQLAAVVVAETTGEDAKGSSMVNATSLPPPLGVLDLLFDGRANVKTFFFNHFEQSVYHLAQRGDPETFLTRLAQLEALTDSIASLDDYAEWFDLWSAGTTVRAQGGADPQALDQIASDSGEAITSDTIQNLLADGNSFVVKTEATDRPYSILQRQLQALFTTMTNVHAYISPPNAQALAPHTDPYDVFVVQVYGQKEWTLCTPQPPGGQNLSDAHKAQWQEIAKHNIQGCTNYQEWQLAKMDCQHITLLPGDLLYIPKGVIHYATTGSVTGSTHLTVSIERLSHSWMMLFHRTCNVEHDHTLCEQLNELIENAATSRPEALIWFDLATAPLEEQPMASICQRLSYLVLGDHPASVLQLAQSATHKLNRYTRSATQIRAALPSIIDCDNLDKLHFASMRLASQLRQSRSSAWRPNCQLDGSCGSQNGCDCDGCDEGITCKVGYRVTNSVNGDCEQCSAGTYSPWGQYCYNCGPGSYSSAGQGGCTSCDAGKYQDSYGQSGCKNVGQGYYASGRARSNRQACSPGFYSNSEVATECKPCSASPFPGNYQDQYAQSACKACPSGKYAANDIATGCVESPGLQVVPTMQAKSLELAVDNSVLHRTAFRVTLGVWKTTEFAYTVASNYPQEFDADEGGEADTSLITLRHLLPGTFYYIKVEGKNEAGNYPDVFEYQLARTTCGCLESDTSGTPGNLTINQYLGRIYFNFIDHSFCEDGFLLYRDGYSFTSAYDVVSSQACERVYSPKTVYDDILNSDDLNVGNVHQYCVSAYSRTAFVWAEDESVSGSYESHQTCTSFQIQWEARIQGRVQLTDSAGKLPVADTSVEWFFQDRPHLGGNLTTGPDGTFTIYVKTSELSNDVESIVVRVAKQSGDISHRYTCSGQPCSEQTLLVSALTFDNEVVFVDATTVPFEGYLFIQGTEHASYANGCPLQGVRVCVINHIEHTSLGCSVTSTAGYFVVPVAAGLTVYPSFDYNNHTFERLNEGRAPTGFYDSVDLAGAPVAYDFYKLESDGSRQAPVIYIDTTTTTMTVQVAGGLCNRTLGNTTLQLSYPTCAASWSQEITFGEYEHLVEVPAQNFDVELISLTHNAVELGDTVPNYFAAKGTRKQRADLLSSRPAAVRWEYHPEPVVTLSMTNNVGGDCNLFILPRDTTTTITVDVTESFWADITACPHIDGNVSIVNMLGETTERAATLVANKAMSKEDAALLSRCADGCLLPLEHELAKDGETVTRAYTSIDAMAGEPELVATIEGVQYAKLLSASISSLYTVEVRQAVIVTGDKIISDLFTMDFPEYFPLMILYDPPGGESFAYYLEVSKVSADIEGKKNRDDSVTFTTTISIQTSEDLGVPSSPVFVTPALTVKYTETKEVIFDMDACDVSIIDKVTWSLDDKSKNTNSFTIKLYGDIKDAEIPTLKNNLVLAEQDLVTAQAEGTSDEQQEAQKKVDKLKEAISGWTSVLNYTDAVLINATQGSLEAVTALMPETLMSAARDLDMKPDAAAESELELYSAISFTGGGQAYTFEETSGVDNSSDSGTMAQKDFHILGAVAAKVQLVGVGPSLDFEIGYTRHEESADITTTDTDVETTRGFVLADGDGGDKFVVKVARDPIFGSFVFTTVAGSSKCPHETNTYAREQPRIIVESEPLSAVYPGQAAVFKLRLINDANEANQYELYVRDVEGAEVFINGDTLAEGRLYEQMPAYSEYTETLYVRQADERTSVSFKLGFRSRCERELFLVLGNWPASSFQHDERELTVDFLAPCSTVAWAGDLLRTSTFVINSALTSPTYRVVVSNPEAPKRYWADNDRLESVLLQYRPFGASSWTTAQNASGQPAELKELESSFGYASVDWKVDGIADGEYELRVFSRCSVASLAAPDGINDFQSVSLLGTVDRSLPRVFAMYPRASTLADTGADVEVIFTEPLQCTRPFTFSVKASIGDSISVSERVLDVICQGHAIKLSIAKTFSASLLSGKTVEIEIANVYDKAGNKVRQPVSWVYQYREVADATPSAVELDGLKFAVTWNAAWADSSSTAFAEFAEQLQGELASLLQVSASRISVESLRESASDGMVLVALRIEVQGGSSRRRSMWTRRDDSNEDLSAEELANLLLTLLYAEDASPSLESGGVLESLNRDEPPSQSVAVSDTSAMTDPEASSGSATAGDDSFNAVEIVTLVLVLLAVVLLAVLVYHVVFSKHKSGASPRLSRRSTKVGDLGMRSDSNKTIVHQFTNVNVDDVPPSEMAAVAPGNKDSD
The following text describes a protein:
Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MDKLFKTSFRFIIRFLQILSLPVVFPYFLLSFLACLITSKNYESLPYNYPPEIRFKKVYRLVSMWLYIKGIKVVTVNDKIIPKKPVLVVANHKSNLDPLVLIKAFGRLKNSPPLTFVAKIELKDTVLFKLMKLIDCVFIDRKNIRQIANALETQQQLIRQGTAIAVFAEGTRILSNDIGEFKPGALKVAYNAFVPILPVSIVGSLGKMESNKRLKEHGVKKSSNYEVKVIFNKLINPISFNQIDSNNLANNIRSIISDAYTSEKPSND
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MKILIFGLGALGTVFATSLKASGETVFGITKDKYIGKINNKTLEIKGLFGEKRAQLDNIFTSSEQIQDRDLDLIIVSVKAYDTETVINQIKHLLGQNTLVLLAQNGYGNYEIASSVIGKERVILSRIIFGAKIVEPAIAEVTVFADDIVIGQPDNMISEKKLNEIADIFNKAGLPTRVSKEVYAILWDKILYNSALNPLGAILECNYGTLAKHEETRKIMNKIVEEIFNVAKFKKIKLNWADYKEYLNYFYEKLVPPTAKHFPSMYYDIKNGKKTEIDAFNGAIVKLAKQCNLSVPVNETITNLVKVKENLI
The following text describes a protein:
Function:
Ribosome-inactivating protein of type 1, inhibits protein synthesis in animal cells. Inhibits cell-free translation in rabbit reticulocyte lysate system with an IC(50) of 0.17 nM.
Sequence:
RPSWTVDSDSAKYSSFLDSLREEFGRGTPKVCNIPVTKKANNDKFVLVNLVLPFNRNTITLAFRASDAYLVGFQDRDSKTNKLRANFFSDEYRALSGKYKSIFTDAEVLAPALPCASTYTDLQNKAGVSREKLSLGVSSLQTAFTAVYGKVFTGKNVAKFALISIQMVAEAARFKYIEDQVINRGMYSSFEAGARITLLENNWSKISEQYHKSCKLGGGQFTEEEMKLGLLLYN
The following text describes a protein:
Function:
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Subcellular Localization:
Cytoplasm.
Sequence:
MRLSRFFLPILKENPKEAEIVSHRLMLRAGMIRQEAAGIYAWLPLGFRVLKKIEQIVREEQDRSGALELLMPTLQLADLWRESGRYDAYGPEMLRIADRHKRELLYGPTNEEMITEIFRAYVKSYKNLPLNLYHIQWKFRDEQRPRFGVMRGREFLMKDAYSFDLNEAAARVAYNKMFVAYLRTFARMGLKAIPMRAETGPIGGDLSHEFIVLAETGESGVFINRDVLDLPVPGEDVDYESDLTPIIKQWTSVYAATEDVHDAARFEQEVPEAKRLNTRGIEVGQIFYFGTKYSEPMKAMVAGPDGVDVPIHGGSYGVGVSRLLGAIIEACHDDAGIKWPEAVAPFRAVVLNLKQGDAAVDAACEKLYAELQAKGVDVLYDDTDQRAGAKFAAADLIGIPWQIMIGPKGLADGKVELKRRSDGSRETMSPADAVARLVG
The following text describes a protein:
Function:
Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences.
Miscellaneous:
MISCELLANEOUS: The sequence 23S rRNA from clinical isolates of erythromycin-resistant S.aureus is methylated and is not recognized by Tlr13 anymore, suggesting a link between antibiotic resistance and evasion from Tlr13 recognition. 23S rRNA modifications generating resistance toward MLS antibiotics preventing recognition of bacteria from Tlr13. These data may also explain why Tlr13 is not conserved in human: human may instead possess a related rRNA-sensing pattern recognition receptor that has evolved to recognize species that can hide from Tlr13 owing to rRNA modifications.
Subcellular Localization:
Endosome membrane; Single-pass type I membrane protein.
Sequence:
MSGLYRILVQLEQSPYVKTVPLNMRRDFFFLVVTWMPKTVKMNGSSFVPSLQLLLMLVGFSLPPVAETYGFNKCTQYEFDIHHVLCIRKKITNLTEAISDIPRYTTHLNLTHNEIQVLPPWSFTNLSALVDLRLEWNSIWKIDEGAFRGLENLTLLNLVENKIQSVNNSFEGLSSLKTLLLSHNQITHIHKDAFTPLIKLKYLSLSRNNISDFSGILEAVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHLSFEGNKLRELNFSALSLPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKLENLSAKHLQNLRAMDLSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLAKCTRLLFLDLGQNSDLIYLNDSEFNALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPDFAFSPLKHLEFLSLSRNPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNHGTFRPLKKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLFSGLEKLLILKLGFNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSNFFQGLGSLQELLLGKNPSVFLDHHQFDPLINLTKLDISGTKDGDRSLYLNASLFQNLKRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNLKSLMFFDVYGNKLQCTCDNLWFKNWSMNTEEVHIPFLRSYPCQQPGSQSLLIDFDDAMCNFDLGKVYFLCSFSMVLSTMVFSWFSTKMIASLWYGLYICRAWYLTKWHKTEKKFLYDAFVSFSATDEAWVYKELVPALEQGSQTTFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLEVQLASMKMFYEHKDVIILIFLEEIPNYKLSSYHRLRKLINKQTFITWPDSVHQQPLFWARIRNALGKETVEKENTHLIVVE
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MSSSGALSNYYVDALLGPESEEVYAGRLVAAGPPRPSGAGPDGGDFSSCSFAPKSAVFPAGWPAVPAQPPPAVPGLYHPYAHQPHLAAAEPARYVRSWIEPFPSLPGGSGPGSSSTGRLYGIKPETGPAASSSSSSSTSSSTSSSSSISSSSISSSSSTTTSKRTECASARESQGISVSEYTCNSFLQEPGEKAAAAGGKEAPGCSDHPGRSSQLKEEQQQQQQQQPQQQQQQQQQPQQQQPPQPQQPQQQLDPNNPAANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRRMKMKKMNKEKGSKGD
The following text describes a protein:
Function:
Has an essential role during oogenesis and embryogenesis, perhaps in modulating the levels of nuclear import of additional proteins. Modulates the nuclear import of dorsal (dl), Dif and male specific lethal 1 (msl-1). Negatively regulates nuclear import of dl and controls the accumulation of dl in the nucleus after immune challenge.
Miscellaneous:
MISCELLANEOUS: 'Tamozhennic' means 'customs officer' in Russian.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDFVPHDLIPDLWDEILRRHWMFLETEESIEKLEERKQLEGCLKEFLCVVQHDRKFFLPETGHVLRRSVLELPDFSAQNAIVAFETISQYANNLFTKPWRKEYRTLKTYSGCFQHDIQSRLLDAEQLFLAMGYRRAAEDTFVLEGPICPDQVTNVSRDAMAAYVECQIMKHIYAGVTAAGYVCTWKDILQFRERYVGGTSTTIKEMVRQLSEKRVRMEQPPMQENTYSNVVSAAPTACGMRSNNVAHHPSSSGTCALHPNGLNEAGKYLPPYPAPPPQQPHLPGPLMTHSRSLDHYQEPQAHLPHRHSFDQQLQQQCQLPHVYEAPYDCLDGLSMGSSASYAAVTGAYNAPGNRYPLPYNISSQLNAPYASPADFYGNGQHTNMYATLGKTGPAHSCDLHRRQPNTSAAAAAALAAMQHRQSTYPPDHHLIDFDERAHLTQHDFGTHDYDPQYAELRGQVQPSMRGNPVAMYATYGGYDLPTTLPQAPPPTGQDMYIYARPVPKSSRMRALAEAGGINSTDKHPRSAEKQSTMDNNRKMHKELKERNSRTAPAKRSGTERDIPTTISDLNSYDSASLDGFVALDSSSSPPLMPKVQEGVGSFESWNYVFKNLERSGYTKDLGDREDLLVQSLDLGSLSITNGGAAPPAEKRREATNPTNGEKARTLDKKSGTGRREAKVVQAPAPSPLPNSSSAGVKKVKSALKTAVVDNRGTGSRQRTGAVPKQPPNVSPQLIVTSPNEWSCSFCTFLNPDTKRICEMCCRSKDFNLEAASAASSSAAAAAASAASVSHASSTCV
The following text describes a protein:
Function:
Has actin-binding and actin-bundling activity. Stabilizes actin filaments against disassembly.
Miscellaneous:
MISCELLANEOUS: Present with 1578 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches.
Sequence:
MSYDKKADVTSLDEDLRQLRESKFSPEAIQNIKIWVYKSVLKEIAPPGDLLECLKDGTVLCKLANILYEADTGEANHISWKSSKMPFVQMDQISQFLSFSRKYGVPEDELFQTIDLFEKKDPAIVFQTLKSLSRYANKKHTDRFPVLGPQLSTKKPRPPVKSKPKHLQDGTGWSTFEYGYMKGASQATEGVVLGQRRDIV
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MRNVMIHHRVFFCCTKPLSILPSLSPPHLHLSYSAAAAAASSPNRAIHCMANDSPLSQPLTGGDGSVSVPPPSPASSAIDFLSLCSRLKTTPRAGWGKRDVKNPESIADHMYRMGLMALISSDIPGVNTDTCIKMAIVHDIAEAEEIAELWREYEANASPEAKVVKDFDKLELILQALEYEQEQGKDLEEFFESTAGKFQTDIGKAWALEIASRRRKQQ
The following text describes a protein:
Function:
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Sequence:
MSFLDCSCISHTAVESISVEDRYETHHFLAHESPSCSLPRTVASEEMTVFSSDANHYELLSELGRGFNNLRMVCMARHKPTGKLLALKQTNLDRCTEEELRLLLVSAMELKLLTVIGVICLRIMHPLXSLGSLDNLLQTYFTDGMSESLIAYLLHGVLKALDYLHQMGYIHRSVKASHILLSADGRVYLSGLHSLYSMMRDGKRSKFVYEFPQHSSSLLPWLSPELLRQDLHGYDVKSDIYSLGITACELASGRVPFQDMHPTLMLLQKLKGWHCCLLDVAPFPLQGLGLKASRSGVDSGIGESVATSSIMRTMTSERPQSPAPKNHSALLHHLVELCLHQQPEKRPSASTLLTHAFFKQVKRHTNDSFLSLMYPALPLTSTQEMSRTSQTAFQCHSMASRNGQDGVWDFS