lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biosynthesis of germacrene-derived sesquiterpene lactones. Component of the parthenolide biosynthetic pathway; parthenolide and conjugates are promising anti-cancer drugs highly active against colon cancer cells. Catalyzes the conversion of costunolide to parthenolide.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDTSTSFPSLFLPTLCTILISYIIIKYVLIWNRSSMAAFNLPPSPPKLPIIGNIHHVFSKNVNQTLWKLSKKYGPVMLIDTGAKSFLVVSSSQMAMEVLKTHQEILSTRPSNEGTKRLSYNFSDITFSPHGDHWRDMRKVFVNEFLGPKRAGWFNQVLRMEIKDVINNLSSNPLNTSINLNEMLLSLVYRVVCKFAFGKSYREEPFNGVTLKEMLDESMVVLAGSSADMFPTFGWILDKLYGWNDRLEKCFGNLDGFFEMIINEHLQSASETSEDEKDFVHSLVELSLKDPQFTKDYIKALLLNVLLGAIDTTFTTIVWAMSEIVKNTQVMQKLQTEIRSCIGRKEEVDATDLTNMAYLKMVIKETLRLHPPAPLLFPRECPSHCKIGGYDVFPGTCVVMNGWGIARDPNVWKEIPNEFYPERFENFNIDFLGNHCEMIPFGAGRRSCPGMKSATSTIEFTLVNLLYWFDWEVPSGMNNQDLDMEEDGFLVIQKKSPLFLIPIKHI
The following text describes a protein:
Function:
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage.
Subcellular Localization:
Nucleus.
Sequence:
MEDYEQELYGVEDDEFEDKFSSELEVLAELEGRRACAPLGAAAGKKPTFEEAITSGDVVPFSTSIYQRPQNGVSPHKSPMETGGRRTWAPYTSLLPGVPTAPKLKKRKLEAVKKLTYGLEEEPISPTSPPRDITPPLSPEDLQGAWNNSDVGLLQRTPPAAKDKKLVLKRPPVLEEYVNVTSTDGTRVFMVLKDDPLGVGVELSRCDGAWRGHGQLHLLGMPFSYLMEQVKDEVGGTPKTEDNVDTAQEVEEEEGKENQDPSQHVLWVDLFTPRHYRELLSDDYTNRCLLKWLKLWDVVVFGREKLAKKPSTEQPPTRVPSKYGREPQKWKSKEQMMEEILEAELDQNNRPRFKVALLCGPPGLGKTTLAHVIARHAGYSVVEMNASDDRSPEVFKTRIEAATQMESVLGAKGKPNCLIIDEIDGAPTPSINVLLSIINRKDVGETETTGGAAGGGKKRKKEGGLLMRPIICICNDQYTPSLRQLKQQAFLLQFPQTLPSRLVQRLNEISLRQGMKADTGTLMMLCEKTENDIRSCINTLQFLYGQGQKELSSRMVQTMSIGLKDQKKGLFSIWQEIFQLPKIQRQRIGQDLFLPDQALLDGDSGPRGRGPLHTSSQRFHHILHITTSTGDHEKVAQGLYDNFLNMKLKDSTLNSVCTAMDWLIFEDILDQAVRHGQNFQLMRYFPFLPVAFHLLFAANSVPRISYPNSQHEALNKTNQTQNLIMSLVSGVTPAARSRAAPQSLILEALCLLLDIISPKLRPVSTQLYSNKEKQQLANLINIMLAYNLTYHQERTPDGMYTYKLDPNIEDVCRFPDLPARKQMTYQAKQLIAREIELEKMRRMESAVQNPQESSGEKGAPGAPIRNHQQRLEHIMKRKTVFEEKVCLRWFKEKNSGPERDSMERRMGKAVGKSDVWFRFNEGVSNAVRRNLYIRDLI
The following text describes a protein:
Function:
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
Sequence:
MPLTVSCPICKTPVEWGPQSKFKPFCSERCKMIDLGDWASEKHAIPVKSEFDLDALDELGYDEDSFFKE
The following text describes a protein:
Function:
Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity.
Subcellular Localization:
Cytoplasm.
Sequence:
MDFSKLPKIRDEERESQFGYVHGVSGPVVTASNMAGAAMYELVRVGHCELVGEIIRLEGDMATIQVYEETSGVCVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDISDSTQSIYIPRGINVSALSKDIKWEFNPSKSIRVGSHITGGDIYGAVMENSLIRHKIMLPPRNRGTVTYIAPPGHYDTSDVVLELEFEGVKDKFTMVQVWPVRSIRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKTESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYTRALDEYYDKHFQEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLYNMIAFYDMARRAVDTTAQSDNKITWSIIREHMGEILYRLTSMKFKDPVKEGEAKIKADYAQLLEDMQNAFRSLED
The following text describes a protein:
Function:
NADH-dependent cytochrome b5 reductase that reduces coenzyme Q6 at the plasma membrane and mediates lifespan extension by calorie restriction by shifting fermentative to respiratory metabolism, probably through modulating the NAD(+)/NADH ratio.
Miscellaneous:
MISCELLANEOUS: Present with 29000 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSKEDIEGTNILDEPVHGIYIPAALFVVGVAITTYMSGELKILWSLPILFMIIFVRAYSAYKRRRSLYPDRWTSLELEDQTIISKNTALYRFKLKTRLESLDIPAGHHVAVRVPIDGKQEVRYYNPISSKLESGYLDLVVKAYVDGKVSKYFAGLNSGDTVDFKGPIGTLNYEPNSSKHLGIVAGGSGITPVLQILNEIITVPEDLTKVSLLYANETENDILLKDELDEMAEKYPHFQVHYVVHYPSDRWTGDVGYITKDQMNRYLPEYSEDNRLLICGPDGMNNLALQYAKELGWKVNSTRSSGDDQVFVF
The following text describes a protein:
Function:
Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSYQQSQEMYHDNSSARSPGSQRHQQPLHRQPSRQFDAYGPMPVNLYDDSMARYDTGRLERLNPSLHNNSYAYDLSGSQTWNPNGFANAQTLGAIRSASASLKTTSRTGRAGLPTTWLDQQPGMPSPFSNLGPGPLQSGAVRSETTVPSEGEDELIPTAIVIKNIPFAVKKEQLVQLMTELNLPLPYAFNYHFDNGVFRGLAFANFTSAEETATVIEVLNHFELQGRKLRVEYKKMLPLQERERIEREKRERRGQLEEQHRPMAASQLQTQSSMSSLTSHIPATSPSPVSQRGQKLEVDLNDSTTLSYYSQLLLFKEDPSRDSVLFPPTLTPIQRRTVHTLAHNMGLGHASRGTGEQRQVQVFKVAPGTNVSPPLTSIPTAVQPADTARRGLNRAATIDFSEARNEGGPGPFSNLRGQTSGFLGVLDSPGNYGSTQNLRAAKSFADLRSYTPSPVPSSASFPAALQSNGTRLQHYEAVTSGASNTPTLTSAPSGSSLGVQRDDNLLVNSLSSLSLGTGIGGPNSSPRRLRGMFSWDQPENQPSSAGPIGSNRSIGLGFDGQSQERMPIRQPRGPVPEKGSGFRRSNGHQSRGSDELRTNSGVEIIVE
The following text describes a protein:
Function:
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone.
Sequence:
MAHTQRQQGGSRGQWSRCLLLLLLLPLAAQPGRAAIQIPSSYYISDLKIPPAITTQPESVTVFSVEDLVMRCEASGNPSPTFHWTKDGEEFDPSSDPEMKVTEEAGSSVFYTLSNTMDTLKQYQGKYICYASNELGTAVSNAAVLMIDAPPVQQKEKKVTEKAEAGHSIALSCNPPQSSMQPIIHWMDNRLRHIRLSDRVMVGKDGNLYFANLLTEDSRNDYTCNIQYLATRTILAKEPITLTVNPSNLVPRNRRPQMMRPTGSHSTYHALRGQTLELECIVQGLPTPKVSWLRKDGEMSESRISKDMFDRRLQFTNISESDGGEYQCTAENVQGRTFHTYTVTVEASPYWTNAPVSQLYAPGETVKLDCQADGIPSPTITWTVNGVPLSATSLEPRRSLTESGSLILKDVIFGDTAIYQCQASNKHGTILANTNVYVIELPPQILTENGNTYTFVEGQKALLECETFGSPKPKVTWESSSISLLLADPRVNLLTNGGLEIANVSHDDEGIYTCLVQGSNISVNAEVEVLNRTVILSPPQALRLQPGKTAIFTCLYVTDPKLSSPLLQWRKNDQKIFESHSDKKYTFDGPGLIISNVEPGDEGVYTCQIITKLDMVEASSTLTLCDRPDPPVHLQVTNAKHRVVTLNWTPGDDNNSPILEYVVEFEDQDMKENGWEELKRVAADKKHVNLPLWPYMSYRFRVIAINDQGKSDPSKLSDLYKTPADAPDSNPEDVRSESTDPDTLVITWEEMDKRNFNGPDFKYLVMWRRVVGSGPDWHEEYTIAPPFIVTDVQNFSAFEIKVQAVNKKGLGPEPDPIIGYSGEDVPLEAPLNLGVLLENSTTIRVTWSAVDKETVRGHLLGYKIYLTWGHHRNSRAQEPENIVMVQTGANEEKKSITNLRPYCHYDLAISAFNSKGEGPLSEKTSFMTPEGVPGPPMSMQMTSPSESEITLHWTPPSKPNGILLGYSLQYRKMQSDDNPLQVVDIASPEITHLTLKGLDRHSHYQFLLMARTAAGKGLSIEILGATTLEGLPPANISLSAEERSVNLSWEARKRHRTVGFQIHYFSKNGTKNGGKWKKTEMVNSSLQFFQLQGLTPGSHYRLLFTYKNNTFWETEIQTKGTSVTEVQPSFATQGWFIGVVSAVVLLLLVLLILCFIKRSKGGKYSVKDKEDGPMDSEARPMKDETFGEYRSLESDLEEKRTASQPSLGEDSKLCSEDNLDFNGSSAVTTELNMDESLASQFSRHSEGPEPFHGVPDNSPLNPAANPPATNGAPSFLN
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MREIFGSKNEEEMELIKKVLKTCEFIAVDTEFPGCLKETPIGATDETRYKNLKFNVERTKPIQLGFTLFERDGSIGGTWEVNFKDFDARTDACNEKSIEFLRRNGLNFKKIRQEGTLEAFNKTVEETLGLTFDVKKIVVDCKGVSARYGLQRIADNLHIKRVGDAHHAGSDSELTARVFTDLIFSISKEQKRELEEEKQNEERVRRAMHIMHESEQKRKREEEEETEERMKRAMHIMHEAEEAFVMERRGYVTVQPRCGYLPVLHPPPRPVVFHPYPPQFAGYFCLAFIWSEIWLEMVMFLPFDYWVGTVIEDGKDDLVAYRCQLSFILRVSLCQLSFCTQQTVTSLVNKRETR
The following text describes a protein:
Function:
May have a major role in the perfection of crystallization, involved either in the pore structure itself or in the organization of the pores within the linear array of terminal synthesizing complexes (TCs).
Sequence:
MTIFEKKPDFTLFLQTLSWEIDDQVGIEVRNELLREVGRGMGTRIMPPPCQTVDKLQIELNALLALIGWGTVTLELLSEDQSLRIVHENLPQVGSAGEPSGTWLAPVLEGLYGRWVTSQAGAFGDYVVTRDVDAEDLNAVPRQTIIMYMRVRSSAT
The following text describes a protein:
Function:
Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.
Sequence:
MRVSVANHLGEDAGHLALRRDVYSGLQKTPKSLPPKWFYDTVGSELFDQITRLPEYYPTRAEAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDALRHRGSLRRFVPFDVDASVLSATATAIQREYSGVEINAVCGDFEEHLTEIPRGGRRLFVFLGSTIGNLTPGPRAQFLTALAGVMRPGDSLLLGTDLVKDAARLVRAYDDPGGVTAQFNRNVLAVINRELEADFDVDAFQHVARWNSAEERIEMWLRADGRQRVRVGALDLTVDFDAGEEMLTEVSCKFRPQAVGAELAAAGLHRIRWWTDEAGDFGLSLAAK
The following text describes a protein:
Function:
Catalyzes three successive oxidations of ent-kaurenoic acid giving gibberellin 12 (GA12), a key step in gibberellins (GAs) biosynthesis. GAs, which are involved many processes, including stem elongation, play a central role in plant development.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MESGSIWVVLAVIFGGLGVGKWILKKVNWWLYEAQLGEKQYSLPPGDLGWPFIGNMWSFLRAFKSSDPDSFMRTFINKYGDNGIYKAFMFGNPSVFVTTPEACRRVLSNDDAFKPGWPISTLKLIGRKSFIDISYEEHKRLRRLTSAPVNGHEALSVYIPYIEENVIAMLEKWTTMGKIEFLTQVRKLTFKIIMYIFLSSESEVVMEALEKDYTTLNYGVRAMAINLPGFAYYKALKARKRLVAIFQSIVDERRNLRKNSARNAKKKDMMDSLLGVEDENGRKLTDEEIIDVILMYLNAGHESSGHITTWATIFLQEHPEFLQKAKEEQEQIVKRRPPAQNGLSLKEVREMDYLSKVIDETLRLITFSLTVFREAKTDFSINGYIIPKGWKVLVWFRTVHLDPEIYQNPKEFNPSRWDNYTPKAGTFLPFGAGSRLCPGNDLAKLEISIFLHYFLLDYMLERENPECRWMFLPHTRPTDNCVARIKKVSSTSV
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.
Subcellular Localization:
Periplasm.
Sequence:
MLYLHPRLIMKINKITALVLTALAVTQFAGFAAHAATQQLTVWEDIKKSAGIKEAIADFEKQHQVKVNVLEMPYAQQIEKLRLDGPAGIGPDVLVIPNDQLGGAVVQGLLTPLSVDPTIVTTFTKPSIAAFTMDNALYGLPKAVETLVMIYNKDMLPTPLATLDEYAAFSKKQRAENKYGLLAKFDQIYYSWGAIEPMGGYIFGKDANGSLKANDIGLNTPGAVEAVTYLKTFYANGLFPIGTIGDNGLNAIDSLFTEKKAAAVINGPWAFQPYEAAGINFGVSPLPALPNGKDMSSFLGVKGYVVSTWSKDKALAQQFIEFINQPQYVKTRYQVTKEIPALTAMIDDPLIKNDEKASAVAIQASRASAMPGIPEMGEVWGPANSALELSVTGKQEPKVALDNAVKQINMQIEAMQASNQ
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MQPALAPHPSAQDHADQVLHDQLLAAQHQHLTHPQQARPQPPAPQPPHMQPNTPARDQNNIDPAISGATMLTGPPQTPTQPDVTGQETPKTYGKRPLSTSKRAAQNRAAQRAFRQRKEAHIRELEGKVKAYESMGEAIKALQAENYQLREYIINLQSRLLDSQGEVPELPGNIDLSQPRSEIPVPPIPNSGTATTTAPPPTAPQQPQPSHAQAPTSNDDMNSLNRIAVAGLGMRKPPTEEANYLGNNFQAQARRVRPDEGQPEASELPKQEQTHGLPLIS
The following text describes a protein:
Function:
Extended-spectrum beta-lactamase (ESBL) which confers resistance to penicillins, as well as first, second and third-generation cephalosporins. Has cefotaxime-hydrolyzing activity. Inactive against the cephamycin antibiotic, cefoxitin, or against the carbapenem, imipenem.
Miscellaneous:
MISCELLANEOUS: The class A beta-lactamase family has a specific amino-acid numbering system, sometimes called Ambler or ABL numbering and often misspelt as Amber. A multiple sequence alignment was used to derive a consensus sequence and then the consensus was numbered taking into account insertions and deletions. This allows use of identical numbers, e.g. for active site residues, despite differences in protein length. UniProt always uses natural numbering of residues, hence there appear to be differences in numbering between this entry and some papers.
Subcellular Localization:
Secreted.
Sequence:
MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL
The following text describes a protein:
Function:
Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrates, such as BACE1. Necessary for O-acetylation of gangliosides.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSPTISHKDNSRQRRSGMFGHALDMKSGPLPPGGWDDNHQDSVGGEGDREVLLGDVGPGDFPKAKRSYRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYFKNFGRRKSWLVPTQYILGIFMIYLSTQVDRLLGNIDGRTPDVVALTVTFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKETREASVVKEETQGITDTYKLLFSIIKMPAVLAFCLLILTSKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLLISKYTAGPQPLNIFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIIVLLSYALHQVTLYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPEAIELCKKLGGSCVTALDGYYVESIVCVLIGFGWWFFLGPKFKKLQDEGPSSWKCKRTN
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MTNIKLYIQYDGSKYNGWQKQKENDNTIQGKIENVLSLMTGEDINLIASGRTDTGVHANMQVANFHTTFQGSTDEILSYCYEYLPKDIVVYDAFHVDERFHSRLNVKKKKYTYKICNKKFHDVFSRKYSYHVPETLDIEAMKEACTYLVGRHDFASFTAARSKKKSTVRTLYSIDIIKKDSYVDIVYLGSGFLHKMIRILTGTLIEIGLHNLKSVDVKIILDAEDRRKAGPTAPSQGLFMTSVDYE
The following text describes a protein:
Function:
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites; Secretolytin has antibacterial activity.
Subcellular Localization:
[Secretogranin-1]: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Lumenal side. Note=Neuroendocrine and endocrine secretory granules. Found to be membrane bound inside the secretory vesicles. The N-terminal region exhibits pH-dependent membrane-binding activity, binds to the membrane at intravesicular pH (5.5) and freed when the pH is near to physiological pH; [Peptide BAM-1745]: Secreted; [Secretolytin]: Secreted.
Sequence:
MQPAALLGLLGATVVAAVSSMPVDIRNHNEEVVTHCIIEVLSNALLKSSAPPITPECRQVLKKNGKELKNEEKSENENTRFEVRLLRDPADTSEAPGLSSREDSGEGDAQVPTVADTESGGHSRERAGEPPGSQVAKEAKTRYSKSEGQNREEEMVKYQKRERGEVGSEERLSEGPGKAQTAFLNQRNQTPAKKEELVSRYDTQSARGLEKSHSRERSSQESGEETKSQENWPQELQRHPEGQEAPGESEEDASPEVDKRHSRPRHHHGRSRPDRSSQEGNPPLEEESHVGTGNSDEEKARHPAHFRALEEGAEYGEEVRRHSAAQAPGDLQGARFGGRGRGEHQALRRPSEESLEQENKRHGLSPDLNMAQGYSEESEEERGPAPGPSYRARGGEAAAYSTLGQTDEKRFLGETHHRVQESQRDKARRRLPGELRNYLDYGEEKGEEAARGKWQPQGDPRDADENREEARLRGKQYAPHHITEKRLGELLNPFYDPSQWKSSRFERKDPMDDSFLEGEEENGLTLNEKNFFPEYNYDWWEKKPFEEDVNWGYEKRNPVPKLDLKRQYDRVAELDQLLHYRKKSAEFPDFYDSEEQMSPQHTAENEEEKAGQGVLTEEEEKELENLAAMDLELQKIAEKFSGTRRG
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNISELYQLSLQTTGVQQATATLLEIYKDPANFSAILETLMNDQNQITRRQAAIGLRTMLSMHWEDLVASGQADALKSQILTALVNEPIQKNRHAIIDAFDPILRDSKLEWPELRNFADSLLSSDDIDQQEVALTIYGVLAQNMDISELSTHLSTLTDLILNALRSGNEDLTIAAAHLTQKLTLVFEAPAPSEVQVCIASILQLFKFYLINESPITYKLANEIGECASQNSCIEANSFLTNLLELANDEEIPEGQIYIIFTPISATIYNKFDDIGEDLIPIIIQSMLTNVARCFIETESAEAQSDAYYICDTLSDLIKKSSDSTSLFENVISEVNESSYGNIFAGAYLIQIFIEMAPEVCGHHINFIMEFLTKQIDTENGCPAVMAVVFQALQVFIRVFNAGLSDYSSILLNGSLLAAQLDDETVEYSALNMLQELLTTIDVNVPNIPEFLDTLVSIAGARTGGVRERALFAVHAFIFAAGETIRDLAPNLYQVFLDAMQEAVTSEDYKLIGTSLRGLATLHKACPEEMSSFAQQTLQTLTESLQSNEIYVITAAQTAAVILSDIPMEGSLQFLTQAVESAFNLLQTPLPSNDNEDEAEIDNEFEMMSEEMREMIELKACCLDLIIAILKNHPEIIQPAAEQLIEHLIGLANNIIDEDLSSLSIECISIMTNKFNLDKNEILAQISDIFSSPYSSTVSKIFEMAASFIKSNSDFGNAQLEMLLEEANSAIDLELPSTEEARDETVEAIDSAVKFLCKIAKYKPELFQKDKFIVNARKLMKKKGGNEIILISYATILGKFFLIHAENLQSIERKTILQILTNSCSLCDGFINPRPLKMFAKVLDKYKENIFQPALAFIEDFIDFPTDCVGRPYHKETIAYIATISLLLANYSDFDISDYISAVVYALPVTIPHISNIYYAGLEQFYKQASKMLDEDTATRIFSGLFKLFTLSASEFNEVKLTIEAAKSAAFVASSLLNAMGGEINENTNQAMIERFQKRLSRYA
The following text describes a protein:
Function:
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAWKQTPLLLLVYMVTTGSGRDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCSVNTSQELHKADSRLYFNWDHCGKMEPACKSHFIQDSCLYECSPNLGPWIQQVDQSWRKERFLDVPLCKEDCHQWWEACRTSFTCKRDWHKGWDWSSGINKCPNTAPCHTFEYYFPTPASLCEGLWSHSYKVSNYSRGSGRCIQMWFDSTQGNPNEDVVKFYASFMTSGTVPHAAVLLVPSLAPVLSLWLPG
The following text describes a protein:
Function:
Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region.
Sequence:
MTSITPVTLANCEDEPIHVPGAIQPHGALVTLRADGMVLAASENIQALLGFVASPGSYLTQEQVGPEVLRMLEEGLTGNGPWSNSVETRIGEHLFDVIGHSYKEVFYLEFEIRTADTLSITSFTLNAQRIIAQVQLHNDTASLLSNVTDELRRMTGYDRVMAYRFRHDDSGEVVAESRREDLESYLGQRYPASDIPAQARRLYIQNPIRLIADVAYTPMRVFPALNPETNESFDLSYSVLRSVSPIHCEYLTNMGVRASMSISIVVGGKLWGLFSCHHMSPKLIPYPVRMSFQIFSQVCSAIVERLEQGRIAELLRVSTERRLALARRARDADDLFGALAHPDDGIAALIPCDGALVMLGGRTLSIRGDFERQAGNVLQRLQRDPERDIYHTDNWPQPSEDSPDGGDCCGVLAIRFHRQESGWIFWFRHEEVHRIRWGGKPEKLLTIGPSGPRLTPRGSFEAWEEVVRGHSTPWSETDLAIAEKLRLDLMELCLNHAAEVDRMRQRLIAVLGHDLRNPLQSISMAAALLSSSDTRTTELRQHISASSSRMERLVSQILDMSRLQSGIGLTVNPVDTDVSQLVRQIVCETDVAYPGLVIEIAIDPQVRAVVDPDRYAQVAANLLSNARHHGLPGRPVLVTLTRQGDEVCLSVLNETSGLSEAQLANLFEPFKRESADNQRNRNGLGIGLYISQAIAQAHQGRIDVDCRDDVITFCLRLPVRQAETGSSS
The following text describes a protein:
Function:
Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment.
Sequence:
MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFHLLCFFMYLYSMILALIND
The following text describes a protein:
Function:
Has oligopeptidase activity and degrades a variety of small bioactive peptides.
Sequence:
MKDRKSIDKKYKWNLNDIYENYDIWESDLEKFEKLTKEVPKFKGEIKKSPKKFVELEILMEKIAKLLDRLYLYPYMLKDLDSTDEITSIKMQEIEMIYSKFATETAWISPEMLEIPEETMNEWIKKYPELQERKFGLSEMYRLRKHVLSEDKEQLLSHFAQFMGSSSDIYAELSISDIKWNTVKFSTGEEIPVSNGVYSKILATNRNQEDRKLAFEALYKSYENSKNTFAAIYRAIVQRNVASCNARNYESSLDRALENKNIPREVYFSLVESTQENTAPLRRYVELRKKALKLKEYHYYDNSINIVDYNKIFKYDDAKEMVLKSVEPLGEDYQQKMKRAISEGWLDVFETKNKRSGAYSINIYDVHPYMLLNYQETMDDVFTLAHELGHTLHSMLSSEAQPYSTADYTIFVAEVASTFNERLILDYMLKNSNDSLEKIALLEQALGNIVGTYYIQTLFATYEYEAHKLIEEYKAITPDILSEIMFNLFKKYFGDMVTIDELQKIIWARIPHFYNSPFYVYQYATSFASSAKLYEDLKANLENREKYLTLLKSGGNNHPMEQLKLAGVDLTKKESFDAVAKEFDRLLDILENELKKINLI
The following text describes a protein:
Function:
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSGSRSFFTPQETRLELPQGAAHQTPDITRPASPSENDRAPFLNGGPSDAREDVRMGAKALRNDSEKPAVGIMALAPILCYCAASITMTVVNKFTVSGRGFNMNLLVLLIQSTVGVTCVWIAERAGLIQLRGLNAKDAWNWMPLSIMLVFVIWTGSKALQYLNISVYTIFKNLTIILIAYGEVMWFGGRVTRIVLCSFLFMVLSSVIAAWSDISNVFAIGNLSMPHTPDSIMGGMAKDPITGALFPAFDPLKTEKDAINAQLQSASANDVIEGFQGYGLLSSGYVWMALNCICSATYVLLMRKRIKVTGFKDWDTMFYNNFLSIPVLLLMSFLVEDWSYANLHKNFPDDKQTKLISAIVFSGACAILISYTTAWCIRATSSTTYSMVGALNKLPVALSGMVFFHDPPVTFSSVSAIAVGFFAGLVYAFGKNKQAEAAKLGGHASANGSSSMSGSKDGSSLPMHTFNDRKD
The following text describes a protein:
Function:
Transferase involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS). May catalyze the addition of the terminal heptose (heptose IV) to the outer-core glucose III, the last step of the lipid A-core oligosaccharide biosynthesis (Probable).
Sequence:
MRLGTFHKKKRFYINKIKINFLSFLFRNKINNQITDPAQVKSCLIIHDNNKLGDLIVLSSIYRELYSKGVKITLLTNRKGGEFLSNNKNIFEFCIKESTGFLEMLTLCKHLRDLQFDIVLDPFETMPSFKHSLILSSLKDSYILGFDHWYKRYYSFYHPHDECLKEHMSTRAIEILKHIYGEGKFSTNYDLHLPVDVEDKIKEFIGDTRIVIINPLGAKKICRLTFEQIKVIYQEVKTHFENYRIIFTGLPQDLLTIPILEIETLPFDEFIYTVALTKYSDFVISVDTALVHIAAAYHKPTLAFYPNSRTPEYPSHLIWSPNHHKSIQIVSPTYTVKDIDTETLTNSVKRLSCIDKK
The following text describes a protein:
Function:
Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Pays a pivotal role as a pathogenicity determinant during infections and contributes to the ability of the pathogen to persist within the mammalian host. Digests an immunodominant cell surface antigen (SOWgp) and prevents host recognition of endospores during the phase of development when these fungal cells are most vulnerable to phagocytic cell defenses.
Subcellular Localization:
Secreted.
Sequence:
MRVSVPVLALAFGSLAAAAPNAGRRTCGSVPPPEFFEASEKVAALEESGAFADLQAPIEVETYFHVVASSRSERDGYISDQMLSDQIRVMNEDYAPHGVHFNLRETTRTINPSWASDGNEIAMKRSLRKGGYAALNVYFLKDLGGALGYCYFPTNAAPGSTTFIRDGCSVLSSSVPGGSGAPYDLGKTATHEVGHWMGLFHTFQGGCSGQGDYVSDTPPQRSPSSGCPVGRDSCPGGGVDPIHNYMDYSVDSCMNQFTRGQGTRMSSMWRQFRAGK
The following text describes a protein:
Function:
Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (By similarity). TRAPP II complex also has GEF activity toward RAB1A (By similarity). TRAPPC14 is required for ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Vesicle. Midbody. Note=During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission.
Sequence:
MVLMMESQCEYFMYFPAVPISDLSDPAKYRTLPRRSHLYLGETVRFLLVLRSQSASGSSDGSCGSEQHSSRSWRELAGSLSAVASVSPGDSRQRTQPLYHDYHSSGDECVEDTDEDDAAEAVGCPGRGGPRYRGFRECKPLLIHNNPGNGVREFRRAPVQSPVDEPVVLSDEVIFPLTVSLDKLPVNTLKVKIIVTVWKQEEEKAEIQEHGYLSILQQKSPCQTFRQDLNTFKAQVSTTLNVLPPPTVKCQQMTVSGRHLTVLKVLNGSSQEEVCVRDVKILPNFNASYLPMMPDGSVLLVDNVCHQSGEVAMASFYRMDSESSHLPSMLSALEEQNFLFQLQLNNQPQDDSNEGLEVPLVAVLQWSTSKLPFTNSIYTHYSLPSIRLDRPRFIMTASCPSAVRTRENFRVRYTLLNNLQDFLAVRLVWTPEGRGQKEDPAVNAVVCHSPLSNLGYCRKGSTLSVSVAFQILRAGLFELSQHMKLKLQFTASVSNPPPDARPLSRKNSPSSPAVRDILDRHQASLSLGRSQSFSHQQPSKFHLTRTGSVMERRAITPPVGSPVGRPLYLPPDRNILSLDKIAKRECKVLVLDSHN
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MSSSSPSGSGGDDLSERRGIPAAKFIQDVETYLSQSGFDSNSALAFHQERLQQYKVVEMKLLAQQRDLQAKIPDIEKCLEVVATLEARKGTGESLLADFEVSEGIYSRACIEDTDSVCLWLGANVMLEYSCEEATALLKNNLENAKASLEVLVADLQFLRDQVTVTQVTIARIYNFDVHQRRVNQVTPTAIAAADA