lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the NF-Y/HAP transcription factor complex. The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSGNEDFIYDDNSSSSISNQTDGGGGGGSSNNNSGGNANNNNNEGDREQDRYLPIANIIRIMKKALPNNAKVAKDAKETVQDCVSEFISFITSEASDKCQQEKRKTINGEDIIAAMVSLGFENYVEPLKVYLLKYRETEKNSNNKRSPKKSESSSPPESPPLAHLDNSINSGYQPPPPPQQQQQQPPQVQQQQQQQQQQQQQQLQQQQQLQQHQQQQLQPQQQQQHLQQHLQQQQPQQQQQPPQQQQQQLTTTTTTTSTNNQQYQQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVQPPYILQQHNIQQPNVFLNQQAQQQQQQQQQQQQPMMNIQSHQQQFPQQHQIQQHLQQQHQHLQQIHNMQPPHQQMQFNQQFQMSQQIQMPQQFSNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNNNNNNPNNNINNNLNNSSNSLHNSGNSLHNSGNSGQIPPLYQQPYISTNPEYPSTS
The following text describes a protein:
Function:
Plays a role in regulating magnetite crystal size. The lumenal domain may bind the magnetite crystals, affecting crystal size and shape (By similarity).
Miscellaneous:
MISCELLANEOUS: The most abundant protein in purified magnetosomes; MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)).
Subcellular Localization:
Magnetosome membrane; Multi-pass membrane protein. Note=Purified magnetosomes remain attached to each other. Resistant to trypsin digestion in isolated magnetosomes. Localizes as a filament-like structure in a straight line running through the center of the cell, in a position that corresponds to magnetosomes.
Domain:
The lumenal magnetite interacting component (MIC, residues 36-56) probably binds magnetite.
Sequence:
MSFQLAPYLAKSVPGIGILGGIVGGAAALAKNARLLKDKQITGTEAAIDTGKEAAGAGLATAFSAVAATAVGGGLVVSLGAALIAGVAAKYAWDLGVDFIEKELRHGKSAEATASDEDILREELA
The following text describes a protein:
Function:
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Subcellular Localization:
Nucleus.
Sequence:
MVLGGTEKPEVPLPVAEVGLFSCSLLQVLRWVSAALETELRLGGQSLGSFGRAHAALGERRALGTGCPGAPSRGRSETTQNRAGGQETKMDSKKEAAEESTQPPERKKFTIPLEEAPPLEVKSLFKSSRNLPSPGTSVLGSNPTYADYTTARLGPGRAQPEAIPRRVQAGAPPLGAQPGVPPQRALPEEAAPSLGPPGGDTANQGPQGPKPTTKSNSILVSPRQRGNPVLKFIRNVPWEFGEIVPDYVLGQSTCALFLSLRYHNLHPNYIHERLQGLGKNYALRVLLLQVDVKDPQRALKDLAKMCILADCTLILAWSPEEAGRYLETYKSYEQKPADLLKEKLEQDFVSRVTECLTTVKSVNKTDSQTLLATFGSLEQLTAASQEDLSLCPGFGPQKVRRGGPGDLGIREPQSSGSLLLILQREPEAPRWGGLGV
The following text describes a protein:
Function:
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Sequence:
MRGKLLSFSLFGESHGKAVGVLVEGLPPGIEVSVEELKRELERRKGIERFATKRKETDEPKILSGVFRGRTTGTPVAVIVENRDVDSSYYEEIRNTPRPGHADYPAGIKYFGYNDYRGGGHFSGRLTVGVVIAGYFAKKLLEREGIKVRAYLKRIGRVEAHVSPEELLSSENPYCPDEGAFEAMVEEMERARKAGDSVGGIVEAVAFNVPPGLGGPWEEDIEADIASALFRIPAVKGVEFGLGFGLAELRGSQANDPFVLKDGKVVTETNNHGGVLGGMTTGMPLVVRAAFKPTPSIYLPQRTVDLGRMEEVTLKLRGRFDSCIVPKALPVVESSVAFVIADHLLRRRAWEGMVR
The following text describes a protein:
Function:
Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing).
Subcellular Localization:
Cytoplasm.
Sequence:
MAERKGTTKVDFLKKIEKEIQQKWDTEKVFEVNASDLEKQTSKDKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKTCLYPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEEINAKTEDIILKDKAKGKKSKASAKTGSSKYQWDIMKSLGLSDEEIVKFSEAEHWLEYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLIKLKVLEPYPCKLSGLKGKNVFLVAATLRPETMFGQTNCWVHPEIKYIGFETVNGDIFICTPRAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDFAAFRDLKKKQALRAKYGIRDDMVLPFEPVPIIEIPGFGKLSAVTLCDELKVQSQNDREKLAEAKEKLYLKGFYDGIMLVDGFEGQKVQDVKKSIRNRMIDTGDAYAYMEPEKQVMSRSSDECVVALCDQWYLDYGEEKWKEQTCQCLKNLETFCEETRRNFEATLDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTAAHLLQGGDIRGQAESPLGIRPQQMTKEVWDYIFFKEAPFPKTQIPKEKLDQLKQEFEFWYPVDLRVSGKDLIPNHLSYFLYNHVAMWPEESDKWPVAVRANGHLLLNSEKMSKSTGNFLTLTEALDKYSADGMRLALADAGDTVEDANFVEAMADAGVLRLYTWVEWVKEMVANWDSLRSGPANTFNDRVFASEMNAGIIKTDQNYKMMFKEALKTGFFEFQAAKDKYRELAIEGMHRDLVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVDESLIRSSQYLMEVAHDLRLRLKNYMTPAKGKKPDKQPPQKPSHCTIYVAKDYPSWQHVTLSVLRSHFETSSGKLPDNKVIASELGNLPELKKYMKKVMPFVAMIKENLEKTGPRVLDLQLEFDEQAVLMENIVYLTNSLELERIEVKFASEAEDKVREDCCPGKPLNVFRTEPGVLVSLVNPQPFSGHFSAKIEIRQGDNRDSVIRRLMKVDRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEHTEKTPISEQAVFHVDLTSKKVHLTENGLRADIGDTMIYLVH
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MKIFIRGKGYYMGLEEKIELNVEPIDTILKCREYTGGNKTFFDREGRLLGLYEQFQSSGLKEGDTIDICSFPLEIAFLTFILQILQVKGNNHLEINRLRTKLFNKTIDNKIYSSQLDKMKHLFNDRVPNDILENVYSDYIKYDSIDRDPLHHFIKRVFNVNKNNKQILASPKLISQKDVIDLDNNNKNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNSNAGSNSITDEEDDLTQPEGDPILLLESSNTIQTEQTEQIQQQLMKPMEDITFEVILDDGKKFISHNKELLDKLKKIEELNWTLARIVSAKVTILPKTVILSNNISSSNSNNNNNNNNNNNNNNNNNNNNNNNNNNAQTSPNLKQQISPTKTTTTTTNTTSTTINKINTPTKDISCLNISTPKTTYNINNTPPSALSINSANSISSVNSVNSVNSSFNYNIEGVDDESTDLEDNDQVFTDTEEDENDRYKVNNNLENSFKRELTEVIRCDTDDFEVYKRSKNGDDVVISSQSYTYNSASQPLPTTNELTTPQISPNSSTSMVPATTTTTTTTTTNTTTTKTTTSQLTPTKKNSLPILNFDNNIPINGDIRKAIESNNENKIKEKKYKPTFQGQPVSFLLALYELRATQDTHFNLEDVKAEAQKFTDVEVRNRDRKGDNAFRNALSMLSQLISRKLINFVREEDLYLTKEGWDFTKPIYPYMQDFKEFTMINKTKMDLAQDKVMILVDSCENFKSDILRNLREKGIFCMEMSLPSSDFLFVKYKEGFQDDIKNLEFYPYLFERKTWSDFNSSRKDTRNIRQKSKMKSYDKIKKSFYIIEGDEILQTNLPMDTLKCHLDQYTLMEGFTIIRSQSLIDTCTQLAIVAKLLSDDPHLSTRDQDSMCNLLEFRNQVLNSRGGNTKESYDQFQDETRSVIISNSNMGEMIRVSISKEQFKEYILSPLYRETVKSKLDDFYNERKLLLFESYESLRKEIYSHHNLLFKGFLTSVEKGLDISNIGYRSENLLLSDYIDNQTISYNLLHILLTFDFQTITHFNQATLSNIRSTSTLNSIVQSCLDFPNPSTTVYNKLIAKPVGK
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region.
Sequence:
MKYINVKDFLVLPHLESLEKQENISNKMSAFRSHCPHLDSVGEITKEDLIQKSHGCCQDCKVRGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVKPLHQTQENSVQDFKIPSNTTLKTPLVAVFDDLDIEVEEEDELKARGLTGLKNIGNTCYMNAALQALSNWPGSVVPTNLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEENLQTVTTEETMEEDKSQSDVDFQSCESCNSSDKAENENGCRSFSEDNNETTMLIQDDENNSEILKDWQKEKMCNKINKVNSEGELDKDRDSVSETVDLNSQETVKVQIHGRASEYITDVHLNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLAPTHKKAQSASSPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPTQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKASYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQEEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAITKCGNVTLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDVLQAEEKIEVETRSL
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTSESPSSRFRELSKYINSLTNLLGVDFLSPKLKFNYRTWTTIFAIANYTGFTVFTILNNGGDWRVGLKASLMTGGLFHGLGKFLTCLLKHQDMRRLVLYSQSIYDEYETRGDSYHRTLNSNIDRLLGIMKIIRNGYVFAFCLMELLPLAMLMYDGTRVTAMQYLIPGLPLENNYCYVVTYMIQTVTMLVQGVGFYSGDLFVFLGLTQILTFADMLQVKVKELNDALEQKAEYRALVRVGASIDGAENRQRLLLDVIRWHQLFTDYCRAINALYYELIATQVLSMALAMMLSFCINLSSFHMPSAIFFVVSAYSMSIYCILGTILEFAYDQVYESICNVTWYELSGEQRKLFGFLLRESQYPHNIQILGVMSLSVRTALQIVKLIYSVSMMMMNRA
The following text describes a protein:
Function:
May down-regulate the expression of spermatogenesis-associated genes in female germ cells allowing their normal differentiation into oocytes. May act as a Ras-mediated signaling protein in early embryogenesis.
Subcellular Localization:
Nucleus. Cytoplasm. Note=In early one-cell embryos, exists only in the cytoplasm and gradually moves to the nucleus at the middle one-cell stage. At the late one-cell and early two-cell stages, higher levels in nucleus than cytoplasm. After the middle two-cell stage, mainly cytoplasmic and completely cytoplasmic after the four-cell stage.
Sequence:
MVICLHCPDQDDSLEEVTEECYSPPTLQNLAIQSLLRDEALAISALTDLPQSLFPVIFEEAFTDGYIGILKAMIPVWPFPYLSLGKQINNCNLETLKAMLEGLDILLAQKVQTSRCKLRVINWREDDLKIWAGSHEGEGLPDFRTEKQPIENSAGCEVKKELKVTTEVLRMKGRLDESTTYLLQWAQQRKDSIHLFCRKLLIEGLTKASVIEIFKTVHADCIQELILRCICIEELAFLNPYLKLMKSLFTLTLDHIIGTFSLGDSEKLDEETIFSLISQLPTLHCLQKLYVNDVPFIKGNLKEYLRCLKKPLETLCISNCDLSQSDLDCLPYCLNICELKHLHISDIYLCDLLLEPLGFLLERVGDTLKTLELDSCCIVDFQFSALLPALSQCSHLREVTFYDNDVSLPFLKQLLHHTALLSQLIYECYPAPLECYDDSGVILTHRLESFCPELLDILRAKRQLHSVSFQTTKCSKCGGCYIYDRHTQCCRFVELL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQAGKLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPAVFGNRHDAVYGPADTMVQYMELFNKIRKQQQVPVAGIR
The following text describes a protein:
Function:
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Domain:
The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity); The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.
Sequence:
MELAELEQALRRVPGSRGGWELEQLRPEGRGPTTADTPSWSSLGGPKHQEMSFLEQGESRSWPSRAVTTSSERSHGDQGNKASRWTRQEDVEEGGPPGPREGPQSRPVAESTGQEATFPKATPLAQAAPLAEVDNPPTERDILPSDCAASASDSNTDHLDLGIEFSASAASGDELGLVEEKPAPCPSPEVLLPRLGWDDELQKPGAQVYMHFMQEHTCYDAMATSSKLVIFDTMLEIKKAFFALVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLVQIYEIEEHKIETWREIYLQGCFKPLVSISPNDSLFEAVYALIKNRIHRLPVLDPVSGAVLHILTHKRLLKFLHIFGTLLPRPSFLYRTIQDLGIGTFRDLAVVLETAPILTALDIFVDRRVSALPVVNETGQVVGLYSRFDVIHLAAQQTYNHLDMNVGEALRQRTLCLEGVLSCQPHETLGEVIDRIVREQVHRLVLVDETQHLLGVVSLSDILQALVLSPAGIDALGA
The following text describes a protein:
Function:
May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.
Miscellaneous:
MISCELLANEOUS: The sequence of the A (or alanine) version is shown. The S (or serine) version differs in only two positions, and the K version in only one. There may be other versions in addition to the S, A, and K versions.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSTAAKQNRSTSRVSKKKTAAPKEGAAKKSDKGHKYEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLYLKQQKGAGDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQFNANVFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKNEISILQNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHELDEYTNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQKKVLILSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVVLTEVDKKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKEWVKGYDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYTQDGLGANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGFYLIKDTKLIY
The following text describes a protein:
Function:
GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.
Sequence:
MSQSDAAKKVLLMGKSGSGKSSMRNMIFANMAAADTRKLGATIDMETTPIKFLGHFALRLVDCGGQDSYMHNVLSMPARNRSSVFSQIGCLLYVFDVESPDFSTIDMIWFSRVISAILETLSESENMEEFKLHILIHKMDLVPEEHRQVVFESKAKEVRNKVEDYSKGKISADMIHIFSTSIWDETIYKAWSTIVQMLIPEIGSLHAPLERFAKFTSACEVIVFETATSLVVARWTDNDATEQIQAVDERRFERASAVVKAFKSASARIRSRFKSMEITHPMYTAVLDSLTETTAILVVAVDPKVVPAAIHLNINLSRPSFAKLPGLSPKAPGSR
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MGPDAKKQKLQSEDHLQNDLPVSCFLAWCKKVGLELNPKVYISTEGTVSQYGMLAREDLSDGELLFSIPRSAILSQNTTRIRDLIEKEQDSLQSCSGWVPLLISLLYEATDSSSHWAPYFGLWPELDPPDMPMFWSEEEQTKLLQGTGILEAVHKDLKNIEKEYNSIVLPFIRRNPEKFCPMKHTLDLYKRLVAFVMAYSFQEPQEEDEEEDIEKDILPPMMVPVADLLNHVAQHNAHLEFTPECLRMITTKSVCAGQELFNTYGQMANWQLLHMYGFAEPHPQNCNETADIQMVTVREAAFQVARTEEDRLEMQKRWDFLCHIEIVGEEGAFVFGLEEVMTEEELKACLKVLCMSTDEFAEYKENDGWEEDEDNDEQTLLTQEISRLPIPWRKLLHLSAELTLKAYKTELSMDEALVNDPTAYAKLSSREQHSLQVQYGQKKILHLLLELTKS
The following text describes a protein:
Function:
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.
Domain:
The C-terminal domain (AA 443-731) contains a nuclear export signal; Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).
Sequence:
MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG
The following text describes a protein:
Function:
Involved in anaerobic NO protection.
Sequence:
MKKSLTNLDLNLLLCLQLLMQERSVTKAAKRMNVTPSAVSKSLAKLRAWFDDPLFVNTPLGLAPTPLMVSMEQSLADWMQMGNQLLDKPHHQTPRGLKFELAAESPLMMIMFNSLSQQIYQRYPQATIKVRNWDYDSLEAITRGEVDIGFTGRESHPRSRELLSLLPLAIDFEVLFSDLPWVWLREDHPALREAWDLDTFLRYPHISICWEQSDTWALDDVLQEMGRKRHIALSLPGFEQSLFMAAQPGHTLIATAPRYCQHYNQLHQLPLVARPLPFDAQQREKLMVPFTLLWHKRNSHNPKIVWLRQAINTLCRRLI
The following text describes a protein:
Function:
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein.
Sequence:
MHQPVTVPGLDMSFLRQEPVFKTPMTFSPRNTGQRATPSRQELWKQELGLDALSDEDGHLSSDEEGMLAGEGGSCTLVEYQALQKELTERNQQRDDLLFKVKSLQDKNKQYKSRLGKEEENKKQQIKIMRKTHDHNLQEKQNLINNLQDVIDEQETRIFEMEAEKRGQTVTRTKKPSSGIQKLVEQINRLQVERGSLQEQLLTTQLNLEQAKLDAAEGQKFLQEKLQDQEKKRHQAENDLIRMRSEQGATDHEKQVQKLEIANERLQREVNDLRSRVHNLSLEEKSPSKVDRSELTKLETANDKLQNKILRLETELAIQAKKMAETRDHQQSGKDREIQTLERQIREKTLEINKLKAQPPQIVKQTVEVESQHSKQHLEQLNRQLRQLQAQLDTQKSENSNLQVQLGSCREAEKAAMEKLNSYEDEMEVVRSELTAEVSQLRRANQNAVQQAKKEVEVKTKTLTGKVTSMQQSLCQVRPLVSELLKDYSALKKEAHMFPMKLQASVRQVQREICKSISDISQTNQDLVRKYRHEMKLRKKYHNELVELKGNIRVLCRVRPVIREDGEGPSARQVVTFDQEDDGIVNCLHKGRWQTFELDRVFTQQSTQEEVFEEVRSLVVSCLDGYNICIFAYGQTGSGKTYTMEGPPSSRGINQRALGELFQIVEEGNKDWSYSITVNVIEIYNEMVRDLLGSDPTEKLDIKLHNEGGLHVPGLTYTQVDCLDDVNDVFQVAINNRATACTNMNEHSSRSHALLIVTVEGTNITTGAKIIGKLNLVDLAGSERVHKSQAAGDRLKEAQNINKSLSALGDVIHSLRSKQPHVPYRNSKLTYLLQESLGGDSKTLMVVQVAPVEKNVAETLASLNFAQRVRTVELGQATQKTETAEMAQLKERLGQLEQDPTSPYFQSPGRNGRTPRGTPTGTTSRLPTSKRRL
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Sequence:
MIRLWLTAGSPARSFGSFTERLAVPQLASRPAVPEAGQPGTLQVRPTWKKMSSLEDQAFGLLNTYSNGFMVSQVLFAACELGVFDLLAEAREPLDSAVVAARLGASCHGTELLLDACVTLKLLRVDTRRGKAFYGNTELSSTYLTTASPTTQRNMLLYLARTTYHCWAHLAEAVREGRSQYLKAFGVPSEELFTAIYRSEDERLQFMRGLQDVWGVDGRSVLSAFDLSSFPVICDLGGCSGALAKECVSLYPGCRVTVFDIPEVVQTAKTHFPLPEGARIRFCEGDFFKDPLPEADLYILARILHDWTDEKCAHLLERVYRACKPGGGVLVVEGLLDADGRGPLTAQLWSLNMLVQTEGRERTPAQYCELLGAAGFGTVCCRRTRGLYHAVLATRGPPAPCFPEVSGAF
The following text describes a protein:
Function:
Acts as a regulator of tubulin stability.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDQPSGRSFMQVLCEKYSPENFPYRRGPGMGVHVPATPQGSPMKDRLNLPSVLVLNSCGITCAGDENEIAAFCAHVSELDLSDNKLEDWHEVSKIVSNVPHLEFLNLSSNPLSLSVLERRCAGSFAGVRKLVLNNSKASWETVHTILQELPDLEELFLCLNDYETVSCSPVCCQSLKLLHITDNNLQDWTEIRKLGIMFPSLDTLILANNNLTTIEESEDSLARLFPNLRSINLHKSGLHCWEDIDKLNSFPKLEEVKLLGIPLLQSYTTEERRKLLIARLPSIIKLNGSIVGDGEREDSERFFIRYYMEFPEEEVPFRYHELITKYGKLEPLAVVDLRPQSSVKVEVHFQDKVEEMSIRLDQTVAELKKHLKTVVQLSTSNMLLFYLDQEAPFGPEEMKYSSRALHSYGIRDGDKIYVEPRMK
The following text describes a protein:
Function:
May be involved in the development of the central nervous system.
Subcellular Localization:
Nucleus.
Sequence:
MLNNLGANVLGPKDCDLPKAALTALHAGVNSFGQLPVGPNLADLGGGAGGGGSSGGVPVGGGVARLHISGGLCDNSNALNGGNGSSGNGNGNNNNGNGNNNNSMQQQDQKRHRTRFTPAQLNELERCFSKTHYPDIFMREEIAMRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRTPGALLPSHGLPPFGANITNIAMGDGLCGTGMFGGDRWSVGVNPMTAGFGQLNQSSPLSSSLNSGLNSGINMGSALGAGSYQHYGLNALGDSMMYQHSVGGVSCGPSGSPSATTPPNMNSCSSVTPPPLSAQPNSSQNELNGEPMPLHQQQQQQTHQHQQQQTHQHHPMAPPTPTQQQQQLPQSMQSPSDGANDTLHSIAALRRRASELNAIPSYLQMAPHNYEHYNSNSNSVY
The following text describes a protein:
Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1; Involved in cell adhesion and establishing epithelial cell polarity.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell membrane, sarcolemma. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.
Domain:
The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
Sequence:
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQSQKTEISFRPNDPQSYESYVVSIVRFLEKYKDLAQKDDMIFEDCGNVPSELKERGEYNNERGERKVCRFRLEWLGNCSGLNDETYGYKDGKPCVIIKLNRVLGFKPKPPKNESLETYPVMKYNPYVLPVHCTGKRDEDKEKVGTMEYFGLGGYPGFPLQYYPYYGKLLQPKYLQPLMAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MVRLGVLLLLLCVFSHAERVNYSGYQVWHVKAQDDVRLDDVFESLQVCIKGGRDYVDVWRRPLPTSPVYHVMIPGRLIEHVTQLLRHMNVTYDVWIDDVQRLISDDTMKGRLRHRRNPRVFRFNEYHKYDEILGWMEKFARVNSDLVSLFQVGSTYEGRRIMAMKIGVPGGNKQVIWQDSLIHAREWISGATLLWLSHKLVRNYRQHEADVTSLLRRFDWIVLPVWNVDGYIYSWTKDRLWRKSRTNVGPFGCKGVDLNRNFYTPNRGAGISSDYTCSGVYQGNSPFSEPESSSVSRYLSTLNLAAFISIHSYAQYWLYPYGYKSTSSEDNEDLKRVALEAVAAIKRTHGKEYKQGRVIDLAYEVAGGSVDWAHQSLCVKYSYGVELRDRGKHGFILPRRYIVPTAEEYFEAVKVVARHIARNET