lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to the 23S rRNA; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MTKGTSSFGKRRNKTHTLCRRCGRSSYHIQKSKCAQCGYPNSKLRHFNWSVKAKRRPVASLSGIAENCEFIFRGFMNGFREGGLQKSQKHAGAAASVAAPK
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSLNGTFSHNNGLPSGEREESETPGGSTSIISSSFLLQPRASDSRPDALEGKYDKNVLARALKKSRDSCLNGALFEKFLPEENYKLSGGTVFSHVRYIDTATLCVGPLRFEDTKFYFVHYSNSPIEPFAKPNISYVNPQWNELDYRPDSQKLSPGKEKNTLDLKHCLLPSPEYKAPPAKKPEDYEASPGEPVEPLITDASLQRLKSRANEDPTIFNILKRISKGLGTPEQCMLLHNELIGPSTFPLPKRAKKPPRKRITLSINQQDKDEFFDSLINNKKEVRRHFDIVMEFSDAPDTKWIFPRESVLSHVFNTDKKKLEALSLLFHVYRPTEDRNVIDVKTEIKIRDFTPTLRSAIELLTSGTHADRLLSEKRRRMSNLEPKYYMQFHEQT
The following text describes a protein:
Function:
ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies.
Sequence:
MLRKLTVDQINDWFTIGKTVTNVELLGLPPAFPAEAPREEVQRSEEVPSEAPTAQAQDPVKATALARPASAFGRSLSQRSSEVEYINKYRQLEAQELDIYGQDQPPSGPGLRSPLAKISNVACIPETTYKYPDLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKTATEDTRLIYMTTGVLLQKIVSAKSLMEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVILMSATINCKQFADYFAVPVQNKMNPAYVFEVEGKPHTIEQYYLNDLGHIYHSGLPPYRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTWSGAQFVSERSSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIHRDFWDSAIPDHVVPEMLRCPLGSTVLKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAAALSLKNFFTMPFRQHLDGYRNKVHFSGSSRSDCLALVEAFRAWQACRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKNRISQFNMFVDPRHPVLDQEYPYKQRFILQVVLAGAFYPNYFTFGQPDEEMAVRELAGRDPKTTVVLKHIPPYGFLYYKQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVNLAVKMSQLKVSLELSIHAAEEIEGKVQGGSVSKLRNTRVNVDFQKQTVDPMQVSFNTLDRPRTVADLLLTVDVTEVVEVGHFWGYRIDERNAELLRQLTAEINRLELVPLPIHPHPDLVCLAPFTDYNKESYFRAQILYVSGNSAEVFFVDYGNRSHVDLDLLREIPCQLLELPFQALEFKICKMRPSAKSLICGEHWSGGANGRFAALVSGCPLLVKVFSIVHSVLHVDVYRYSGAQDAVNIRDVLIREGYAELAEESYESKQSYEVLKGFFAKSVDTMPDGSVSSPMKDDEKHLIQILLESFASNRLGAPNCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVVISDSPADLHQRMLVAASLSVNETGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDREGKCYTGVLCGLGWNSTTEAPILPEHDIELAFDVCFNVEDIVEINILRAAINKLACDGPHGPKYLGPERIAQLQENARQKLLGLFCRLKPREKITPQWHEKPYEWNQVDPRLVIEQAEREGGPGKSTCLYQLHTPVVLSP
The following text describes a protein:
Function:
The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. Also has a role in transcription-coupled histone modification. Important for TATA site selection by TBP. Directly or indirectly regulates the DNA-binding properties of the TATA box-binding protein, and the relative activities of different TATA elements (By similarity).
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MADFQDELLALAGIDDSDVASNRKRAHDDLDDVLSSSSDEDNNENVGQDYAEESGGEGNEKSEDEFEEKFKNPYRLEGKFKDEADRAKIMAMTEIERESILFEREEEISKLMERRELAIRLHQQNAQYMAQSTRRSTRDKPLTSAAAGKRDKLTELKKRRQERSARSVSERTRKRSPVSDYEEQNESEKSEEEEGYSPSYAEEKVEQVSKDNASANLYDLNAIRLGRKHVAEYMYHPIFESTVTGCFVRVKIGERDGQGVYRLCQVKGILESRKPYRVDGVLTKVSLECFHGRSKRVFDVNVLSNEPFSDHDFQRWHHQMMEDKLSMPSKNFVQRKLNDLRDMSKYVLSEKEVSDIINRKKELSRVPSNIAAEKTRLRQRRQAAYVAGNAELVKEIDDQLNTLEELSMGSNQNSNSAMDQLAKVNERNRRRNHTEIRLAEQRMNEERRRLSAAATATPMSAPTSVLTGTSPQPSPSLSTSIMSTPKLNPSESVVVASEKASSPDLSPKLLPSESQIFDEGIAVTQTPNTLEDKDFKLHEKAVHGIDDIIATVDFGIDINI
The following text describes a protein:
Function:
Acts as a downstream effector for the regulation of actin polymerization by Cdc42.
Sequence:
MEYESSEISDITTGSCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAEDDEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQKKETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLSLNTLMLADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIHTKGLLQYRDGNRKGLPSIKRRFSIREINKTIKSDRRSKMISAPTNFNHISHMGPGDGIQNQRLLDLPTTLETADQACSPIIHSLSCIPQSRKSNFLEQVDANSDDYGNDNIISRTPSPMASSFMDGLSNND
The following text describes a protein:
Function:
Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTEEDGKTQGMKVLGILDIHNTPCAREAILHGAAGSVAAGLLHFLATSRVKRSFDVGVAGFMITTLGSWFYCRYNNAKLRFQQRIIQEGLKNKVFYEGTDLDPTLKKTGDK
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of dCMP to yield dUMP, the nucleotide substrate for thymidylate synthetase.
Miscellaneous:
MISCELLANEOUS: Present with 1510 molecules/cell in log phase SD medium.
Sequence:
MLIGVSGTKFCGCEDVINMLVDHFHFELLNHLDNPEEILDYATKNYTKNSVIFLEKLSLLEKLEKRPFFVHLSIDAPVTTRVALYRKTTQAESLSLEQIIQAIDQHDFQPEGIKLREKSHLRFKIVNEDRRGRRQSLINNITTQLKILDDKEKQMAPLMRPSWDSYFMKLATLAASRSNCMKRRVGCVIVRECRVIATGYNGTPRHLTNCFNGGCPRCNDGDSRNLHTCLCLHAEENALLEAGRDRVGQNATLYCDTCPCLTCSVKIVQTGISEVVYSQSYRMDEESFKVLKNAGITVRQFSFTEEPRIVMI
The following text describes a protein:
Function:
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.
Sequence:
MDFNQKSFRRTLSSSSQGPALSISSSIYRKGGTQYLGAAPSVYGGAGGHGTRISTSRRVVSYGSDQAEGNLWVGNEKMTMKNLNDRLASYLEKVRSLEQSNSKFELQIKQWYESNTPGISRDHSAYLQQIQDLRNQIRDAQLQNARCVLQIDNAKLAAEDFRLKYETERGIRLAVEADLQGLHNVFDDLTLTKTDLEIQIEELNKDLALLQKEHEEEVQSLRAHLGNNVNVEVDAAPSLNLSAIMSEMRQKYEAMAQENLQKAKEQFQLQEVTPISPLLPSLLPFLSPPPTLPSFLFFSSLPYYYFFFSFLLKGAKDEVKNHRRTYQSLEIELQSHLSTKAALEHTLEETKARYGAYLAKLQTQINSLEDQLVQIRTDTEHQINEYNILLDIKTRLEQEIATYRRLLEGEDYKTTEYQLSTLEEKDIKKTRKIKTVVQEVVDGKVVSSEVKEVEESI
The following text describes a protein:
Function:
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives. Has a high affinity for NADPH compared with that for NADH.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLALFLSSSSYPTLSFLSRSVTLNLARTTTLSALTMSMNLKTHAFAGNPLKSKTPKSTDPFSPTSAFESLKTLIPVIPNHSTPSPDFKVLPFSKGRPLVFSSGGDANTTPIWHLGWVSLADCKVLLASCGVDLNEDSLVYLGPKLEEDLVYWAVDLAEDGFVSELGGRKLCFVELRTLMVAADWADQRAMDELAIAGNARALLEWHNVSQFCGSCGSKTFPKEAGRRKQCSDETCRKRVYPRVDPVVIMLVIDRENDRALLSRQSRYVPRMWSCLAGFIEPGESLEEAVRRETWEETGIEVGDVVYHSSQPWPVGPSSMPCQLMLGFFAFAKTLDINVDKEELEDAQWHSREEVKKALAVAEYRKAQRTAAAKVEQICKGVERSQSLSTDFNLESGELAPMFIPGPFAIAHHLISAWVNQAPDDVHSKQQAGVSLSSL
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MESCPSVKNILLLDSEGKRVAVKYYTDDWPVLSSKLAFEKSVFVKTQKANSGAEAEIVMFDGHIVVYKFIQDLHFFVTGGDEENELILASVLQGFTDAVDLILRNNVEKRTALENLDLILLCLDEIVDGGIVLETEGSVIADKVSAHGAEGGTSIAEQTIVQALTTAREHFAKSLLM
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery. In the cytoplasm, catalyzes monoubiquitination of RPS7/es7 in response to stalled ribosomes, initiating a HEL2-dependent response that activates the No-Go Decay (NGD) pathway.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMNPHVQENLQAIHNALSNFDTSFLSEDEEDYCPLCIEPMDITDKNFFPCPCGYQICQFCYNNIRQNPELNGRCPACRRKYDDENVRYVTLSPEELKMERAKLARKEKERKHREKERKENEYTNRKHLSGTRVIQKNLVYVVGINPPVPYEEVAPTLKSEKYFGQYGKINKIVVNRKTPHSNNTTSEHYHHHSPGYGVYITFGSKDDAARCIAQVDGTYMDGRLIKAAYGTTKYCSSYLRGLPCPNPNCMFLHEPGEEADSFNKRELHNKQQAQQQSGGTAFTRSGIHNNISTSTAGSNTNLLSENFTGTPSPAAMRAQLHHDSHTNAGTPVLTPAPVPAGSNPWGVTQSATPVTSINLSKNSSSINLPTLNDSLGHHTTPTTENTITSTTTTTNTNATSHSHGSKKKQSLAAEEYKDPYDALGNAVDFLDARLHSLSNYQKRPISIKSNIIDEETYKKYPSLFSWDKIEASKKSDNTLANKLVEILAIKPIDYTASVVQFLQSVNVGVNDNITITDNTKTPTQPIRLQTVSQQIQPPLNVSTPPPGIFGPQHKVPIQQQQMGDTSSRNSSDLLNQLINGRKIIAGN
The following text describes a protein:
Function:
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles. Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis.
Sequence:
MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQPPPNPSAPLRRIYERPSTTCSKPQRVKQNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATAKEAAKPSSAMDVQFPVPNLEVLPRPPVVASTPAPKAEPAIIPATRNEPIGLKASDFLPAVKIPQQAELVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTTGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDMLAAPPSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRELHLLMASLD
The following text describes a protein:
Function:
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor. The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1. Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO. The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E. The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps. Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8. Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9. Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRVLIIGGSIAGLTLAHCLEKAKIDYVLLEKKEEIAPQEGASIGILPNGGRIMEQLGLYHQIEQLIEPLARAHVTYPDGFHFTSQYPALLQQRFGYPLAFLDRQKLLQILAAGPVQSGRVKLGHQVVNIESTPDGVTVRTSHGHVYQGDLVVGADGVHSRVRAEMWRLATASQGEIFRSEYNKLTIDYACIFGISSPVDQLEPGEQITCYNDGWSILSVIGQNGRVFWFLFIKLDKESVYDGSRKNGPRFSPADARAHCERLAHEPVWNGVKFGHVWAQCEVFQMTPLEEGLFSKWYWRNIVCIGDSMHKFAPHIGQGANCAIEDAAQLSNRLQAWLYGCGPNDPPTASDLSEILAGFVEDRLRRLGPVAVAARSAMRLHARQGVKNWILGRYLLPYAGDKPADWASQGIAGGGVTLDFVEPPERSGPGWVQFSQPRKRPTFPLTVAGLCLVAIVIRMLHSTLTV
The following text describes a protein:
Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome. Membrane; Multi-pass membrane protein.
Sequence:
MNGGMDMGGGGGGGRQELSADNVRGIVLALLSSGFIGSSFIIKKKGLRRAALASGISAGVGGHSYLKEPLWWVGMITMIVGEIANFVAYAFAPAVLVTPLGALSIIVSAVLAHFILNERLHALGVLGCVMCIAGSMVIVIHAPVEQEITSVKEIWHMATQPSFLLYVASVIVLVSVLVFHLSPLWGQSNVLIYTAICSLMGSLSVMSVKALGTSLKLTFEGTNQLAYPETWFFMLVVAICVLTQMNYLNKALDTFNTAIVSPIYYVMFTSLTILASIIMFKDWSGQSLGSITSEICGLIVVLSGTILLHVTKDYERIPQSRIGLYAPLSPTSATRLNGELLRHVEDDARRTDDEEKVLRRQEMY
The following text describes a protein:
Function:
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion. Cell junction, desmosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAWN
The following text describes a protein:
Function:
Probable lipid transfer protein (By similarity). Proteoglycan-like factor that exhibits xylogen activity consisting in mediating local and inductive cell-cell interactions required for xylem differentiation.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MATHSSFTATTPLFLIVLLSLSSVSVLGASHHHATAPAPSVDCSTLILNMADCLSFVSSGGTVAKPEGTCCSGLKTVLKADSQCLCEAFKSSASLGVTLNITKASTLPAACKLHAPSIATCGLSVAPSTAPGLAPGVAAAGPETAGFLAPNPSSGNDGSSLIPTSFTTVLSAVLFVLFFSSA
The following text describes a protein:
Function:
Component of the hydrazine synthase complex that catalyzes the condensation of nitric oxide (NO) with ammonium to form hydrazine. The alpha subunit catalyzes the second half-reaction, i.e. the condensation of hydroxylamine formed in the active site of the gamma subunit with ammonia, yielding hydrazine. Is involved in anaerobic ammonium oxidation (anammox), a biological process in which nitrite is used as the electron acceptor in the conversion of ammonium to dinitrogen gas (N2) and water; this bacterial process has a major role in the Earth's nitrogen cycle and has been estimated to synthesize up to 50% of the dinitrogen gas emitted into our atmosphere from the oceans.
Subcellular Localization:
Anammoxosome.
Domain:
The alpha subunit consists of three domains: an N-terminal domain which includes a six-bladed beta-propeller, a middle domain binding a pentacoordinated c-type heme and a C-terminal domain which harbors a bis-histidine-coordinated c-type heme.
Sequence:
MGKRKLGVIASAFVAGALVCGSTLVNAEPVMTGGPVQGKALWTDYSGMSKEVQGPVSQILFTQSPRTAKGDPYQNYPHYIPEGSRIVLFDLNTKELKVLTNDFATAFDPCTYWDGKKFAFAGVHKKGGGCQIWEMNIDGSGLRQMTDLKGTCRSPIYYAAGSIEEGEGRIIWRDRYFEGDWKEHGMVEKTGMIIFSGSPEGVMDEFHNPYAYNLYRLDTQGGKIIQRITGHVLSGIEFPHLNTTIDQITYNLSSNFDPWLTPDGNILFSSVQANGSRAGGEGRVMICVDNWDGAYPRPIYGNCDGEIGGTSGRSQAKITFGDRKIVYVESPYMNWGVGQLAAVSWDAPFNKTYEKLTGKDGGLYRSPYPLPDDRMLVSYAERGDFGIYWFNFSKCAAGDKVYDDPNWNDHQPAPVYVKYKPRWINTFTAGKNFGVTVVTYQPFDQVKVEGYPHSWGTWICFDTTLSDQPVGPYPHQKAKNVSHGDIKAVRIIQGYQCVEPDSTRFRVGAGAHLLGGERSSSNSGTAFQQRGIIGYQYVESDGSTVTSQLSDVPYYMQILDDKGMSVQTALTWAYLRPYHGRICSGCHYGSYRGRAFKNIHAKALYNWWYDDRSHYDSPFAFRYLKFDNDGNYKGVKHGEDVVVPSDIYYGGPSGTTSQPVEGLTLDKQRTVDFRRDIQPILDAKCAMCHDSNNPPNLGGGLELVSVDGIAAYSRAYNSLLEPQRGKDPNIGGKYVNPSAAINSLLVWRLYEAELSANAPREKIFPIEGRLLHNKFLTQDERYAIVEWIDLGAQWDNIPGPDFYPGYLVK
The following text describes a protein:
Function:
Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.
Subcellular Localization:
Secreted.
Sequence:
MMCLKILRISLAILAGWALCSANSELGWTRKKSLVEREHLNQVLLEGERCWLGAKVRRPRASPQHHLFGVYPSRAGNYLRPYPVGEQEIHHTGRSKPDTEGNAVSLVPPDLTENPAGLRGAVEEPAAPWVGDSPIGQSELLGDDDAYLGNQRSKESLGEAGIQKGSAMAATTTTAIFTTLNEPKPETQRRGWAKSRQRRQVWKRRAEDGQGDSGISSHFQPWPKHSLKHRVKKSPPEESNQNGGEGSYREAETFNSQVGLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGVFDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLLGGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTASFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQPPLCGQTVCDNVELISQYNGYWPLRGEKVIRYQVVNICDDEGLNPIVSEEQIRLQHEALNEAFSRYNISWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGYDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPAYYGMPGHTDTMIHEVGHVLGLYHVFKGVSERESCNDPCKETVPSMETGDLCADTAPTPKSELCREPEPTSDTCGFTRFPGAPFTNYMSYTDDNCTDNFTPNQVARMHCYLDLVYQQWTESRKPTPIPIPPMVIGQTNKSLTIHWLPPISGVVYDRASGSLCGACTEDGTFRQYVHTASSRRVCDSSGYWTPEEAVGPPDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHPVQADTLTLWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKVSGVKVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPVVVTHSHRKFTDVEVTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGDGKVSERLGEECDDGDLVSGDGCSKVCELEEGFNCVGEPSLCYMYEGDGICEPFERKTSIVDCGIYTPKGYLDQWATRAYSSHEDKKKCPVSLVTGEPHSLICTSYHPDLPNHRPLTGWFPCVASENETQDDRSEQPEGSLKKEDEVWLKVCFNRPGEARAIFIFLTTDGLVPGEHQQPTVTLYLTDVRGSNHSLGTYGLSCQHNPLIINVTHHQNVLFHHTTSVLLNFSSPRVGISAVALRTSSRIGLSAPSNCISEDEGQNHQGQSCIHRPCGKQDSCPSLLLDHADVVNCTSIGPGLMKCAITCQRGFALQASSGQYIRPMQKEILLTCSSGHWDQNVSCLPVDCGVPDPSLVNYANFSCSEGTKFLKRCSISCVPPAKLQGLSPWLTCLEDGLWSLPEVYCKLECDAPPIILNANLLLPHCLQDNHDVGTICKYECKPGYYVAESAEGKVRNKLLKIQCLEGGIWEQGSCIPVVCEPPPPVFEGMYECTNGFSLDSQCVLNCNQEREKLPILCTKEGLWTQEFKLCENLQGECPPPPSELNSVEYKCEQGYGIGAVCSPLCVIPPSDPVMLPENITADTLEHWMEPVKVQSIVCTGRRQWHPDPVLVHCIQSCEPFQADGWCDTINNRAYCHYDGGDCCSSTLSSKKVIPFAADCDLDECTCRDPKAEENQ
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MQWSFSNKVSNLPQFMSFKNNTHEDRSRNNVMDPVASSGYMTISTKDAFDSNQKSFLGVTQENLAIKQVGNKHGITIYPIQSSDAQSVCNQEARTISVSNQSNHVITGINMVNSVTNSQTFGSKSSATPLSVLPSKGPIVGSTDLRSRNCSKSNGTTPAQLTIFYGGTVCVYDDISPEKAKAIMLLAGNGTKMQQEISIPSKKDNFIISQPYPSPLPSPIPMTSHASTQPRGGSSSNNEVTIIRTLGHSIAKSSHNDLSHLSSLPSPLPMTSHASSYPKGGSSSNNEVTIIRSLGPSNAPTNHLESPIVATSVGLTPTNVIQPVGLPQARKASLTRFLEKRKERAMSTSPYYMSKISPECSTGSDNASFSIDFSGSSTQPPTNLPLRRTCMEVIR
The following text describes a protein:
Function:
Hydrolyzes the cell wall of L.lactis and M.lysodeikticus. Required for cell separation during growth.
Subcellular Localization:
Secreted.
Domain:
The LysM domains are thought to be involved in peptidoglycan binding.
Sequence:
MPVSRVKVKNRHLKKKTKKPLAFYKPATKFAGAVLIAGTLTTTHELLLQQTSPMVQAATNSSEVFIESIAASAKPVADANGLYPSVMIAQAILESNWGSSQLSRAPYYNLFGIQGTYQGKSVVFKTQEYLNGKWVTKDMPFRVYPSFNQSFQDNAYVLKTTNFGNGPYYAKAWRANAATYQDATAALTGRYATDPSYGASLNRIISQYNLTRFDGASSAGNTNSGGSTTTITNNNSGTNSSSTTYTVKSGDTLWGISQRYGISVAQIQSANNLKSTIIYIGQKLVLTGSASSTNSGGSNNSASTTPTTSVTPAKPTSQTTVKVKSGDTLWALSVKYKTSIAQLKSWNHLSSDTIYIGQNLIVSQSAAASNPSTGSGSTATNNSNSTSSNSNASIHKVVKGDTLWGLSQKSGSPIASIKAWNHLSSDTILIGQYLRIK
The following text describes a protein:
Function:
ATP-dependent protein-folding chaperone for the eIF2 complex. Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MTERDYTTFETIDLTSEEVLQCSYSNWSKLFPGKTFPSKIIKPLPSTFLDYLASESIRLPSNTNNKKITVLEADSDNEYSDWDDEEDQQQDAEHNDNVFSQFQDIQDKIDASIQEMGGAVFTKLNWSSPKDAKWIMPGNTIKCQNVSDVYLLLNSSDHIGDDLDNPFSEVQKKKTIPEKVDYELVLTKWQEINPAYEFRVFVKDHRIIGISQRDNNKYEFLQGLKSELNEKITQFVEDHVIPKLKSDTQLSKYIVDVYVSKNDIYIIDINPFSRKSDSCLFTWVELLDKKDKHDNHHELRLVENQNFAKEFSESQVPIEVVGATMDTEAMVELAREWDKLQAKEK
The following text describes a protein:
Function:
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells.
Subcellular Localization:
Secreted.
Sequence:
MRIHYLLFSFLLVLLSPLSAFTQSINNPITCLTKGGVCWGPCTGGFRQIGTCGLPRVRCCKKK