lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Sequence:
MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDVYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASFLLSYVSCPKPISLTKDSGIDFSHRLCSFKINRVSFPAIKLSRRSTTMSVAPLDVRNIILDGYGYRQRFNVRSYEAETKNITIQSIFNFLEEASWNYVRLFWVYANESGATRRMIKNDLRWVVSRMELQIDEYPNPGDQVDIDTWVGSSGKNGMRRDWEIKWADTGKVFARATSTWAMVNQKTRRVWKMPDEVRAEISHSFIEKQAIIQDHPKKLCKIDDNARYVISGLQPKRKDMDMNNCVSNKTYVDWMLEAIPDECLNNYQLSKIILEYRSECKNSDVVQSISELGEVGIIENGYQENIHMNVNTQGDELPNVRNNRYTHLLQVKGESKCEEIVRGETTWKKRLV
The following text describes a protein:
Function:
Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein.
Sequence:
MSLAIPLCFVPFIVLCTCHNLTVYNTSLDDSGKMELLWQVDYEASTVIFQLRADTDANGFAFGMSDDGTLRKADLVVFWTEGNSVNVADSWTDDHGYFHVDKSQDYHLIDYTANAGKTSVTFSRRFDTCDQQDYRIDSGTTNLLYVLPEHDISAVSDLNNDDARMRFGTKRQQLLKTDTDTPPLPPDVRSFDIRVNQAKIPPEETTYWCRTQPLPTLPAKVHVLQYEPIIAPGNEAVVHHMTVFLCGNDVSSTAGYDGPCEGEEDRRELKTCKHVIAAWAMGAQAFAYPEEAGIPLGGPSASTFAMIEIHYNNPGRRKDIVDSSGVRFHYTPTLRRHDAGIMELGLRYLPSMAIPPRQDSYVITGFCPAQCTVKGLPAGGIQVFASQLHTHLAGTAVWTKHVRSGVELPELNRDNHYSTMFEVKRLFRENEGERGERKKGEKGKEKDRGRYDHYDEGTQGDVLMTSCKYNTADRRSVTLGGYGIHDEMCLNYIHYYPASPLQACKSVVAASALDRFFDVVFSLFGTPNEQNVADDFSHMPWNPLTTAYLTSLYRRGPIDVMCQKTTGEIFEGKWTDLEQPHIRKPQNPQRKCQA
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity).
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon. Cell projection, dendrite. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (By similarity).
Sequence:
MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSTQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVRGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCESHIW
The following text describes a protein:
Function:
Acts as a component of a SCF E3 ubiquitin ligase complexes.
Subcellular Localization:
Nucleus.
Sequence:
MQRQKRLQVQAMSIRSPKSSSPPPWGVLVLLAHHLDPKSLGVASCVSKSWYLSMASDHIWQPLCMSHYPSLSNLKITHPSVSYHRLYAMAYVAAKRRVRGPSVPQFSVDSLIFDIHILGTKDNHPIVKIAKPGNEFCFDHNGVFRFDFGVNNYECLTSSMNEMLEDVKITWNVVLKDWSAVFTMMDYEGKVRYSPGSEGWFSQELPPPRCCSSDSTSGIVADLKLVFYRRKDGGDKVRVDKVSVGILNVVNWRYVIVEDGIRYLQHFLFPS
The following text describes a protein:
Function:
Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation.
Sequence:
MQLYSSVCTHYPAGAPGPTAAAPAPPAAAAAPFKVSLQPPGPASGAPEPESGECQPAAAAEPREAAAAPAAKMPAFSSCFEMVAGATAPAAAAAAGPPGGSCKPPLPPHYTSTAQITVRALGAERLLLPGPEPAAAPAAPAAPAAPRGRCLLLAPAPGAPAPPRRAASAWLLEELLRPDGPEPAGADAAREASERNFRLSEHRQALAAAKPRGPAPPPGSPEPGPGPWAEEHPAERSCRAWERAGERGDPPGAHEARRPEPEPEAPPGRSGDAAPGGAAEAGVVSRADPRDEKLALYLAEVEKQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHCYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNACS
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells.
Subcellular Localization:
Cytoplasm. Note=Accumulates in cell surface projections.
Sequence:
MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSLSLGRSEQPHPICSFQDDFQEFEMIDDNEEEEDEEEEEEEEEEEDGDGDGRAGGGSGSQELSGESLIPSPSIEESHKLRPTTLHLTTLGAQDSLNNNSNGGFTSAPPSSWQETVLRSPVQEPLKELPAPLLPAEEEHHEVQSLARPGCDCEGNQPPEPPASGGASPSSDPGIEADLRSHSSGGHEGRRSSQELSSPGSDSEEAGGARLGRMISSISETELELSSDSGSSSGRSSHLTNSIEEASSPASEPEPEPEPEPLHEPPRRPAFLPVGQDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPPAPRPPEEAASQANPVPQDCPDPEAVAGPHVELVDMDTLCGPPPPAPAAPRLGPAQSGPCLFLSNPTRDTITPLWAPPGRTARPGRSCSAACSEEEEEDEEEDEEDEEDAEDSVIPPGSRTTGSTAPLDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLDNDSEEDSSCEASEEEAGATLLGSDQVPEDASPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCVVNGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSPCWVDRFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMRPVARSVGRAFLEYYQEHLAFACPTEDIYLE
The following text describes a protein:
Function:
Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation (By similarity). Involved in podocyte differentiation.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MVDHLLPVDETFSSPKCSVGYLGDRLASRQPYHMLPSPISEDDSDVSSPCSCASPDSQAFCSCYSAGPGPEAQGSILDFLLSRATLGSGGGSGGIGDSSGPVTWGSWRRASVPVKEEHFCFPEFLSGDTDDVSRPFQPTLEEIEEFLEENMEAEVKEAPENGSRDLETCSQLSAGSHRSHLHPESAGRERCTPPPGGTSGGGAQSAGEGPAHDGPVPVLLQIQPVAVKQEAGTGPASPGQAPESVKVAQLLVNIQGQTFALLPQVVPSSNLNLPSKFVRIAPVPIAAKPIGSGSLGPGPAGLLVGQKFPKNPAAELLKMHKCTFPGCSKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVHRFPRSSRAVRAIN
The following text describes a protein:
Function:
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MATGDCGVITSKTVLLLLSFIFLVAGTTLGFVGGRFITSYEDFDAFFRDQQILLPAIIIMVVAVVMLFLGVTGCFVTVKESQVGLRFFLCILLLMFITEATAFALGFVYREKVVAEVQETMNELFQEYGKQNPETEMVDFWQSQFECCGIKNYTDWINMEWFNRTGNNSVPWSCCKQEFKNCSGLLSEPQELNTMGCAGIMELRVKELINYIMIVILGFAVVKVFTLIFQMNHLQKYFIQNYNQGVMMRILSKISAFGAYFFPWWSRNHCSYAMHFCFPSQS
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular Localization:
Plastid, chloroplast thylakoid.
Sequence:
MMQPNAKLLSPSAKFLPSPIEPPQHNRRTTVGAPPSLERNCKLSRRNLSKSSLLLLLTTQTTLTPLLDFSKAQADTIANPNLTNCENRIPTKKAFIDVSIDGEPIGRIIIGLYGDDVPAGTARFSSIVSGKAGITYRRKDFVKIMPGYVQHGGIRSYGVDAERATAAVGSLQNLIEEWERGKRGEICNVNKAGSVGIVVRDPSKPPPKTKLVARNGKLVVEEEVIAVGPNGTEFVITAVDSPELEDSVLVIGKVLEGMGVVEKMREVKTVRDNTSSPYFRVAKVIGDKRAVVAERGFNRPYSKVVVTNCGLIESQTL
The following text describes a protein:
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Subcellular Localization:
Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MPEGPELHLASHFVNEACGELVFGGCVEKSPVSRNPEVPFESSAYHISALARGKELRLTLSPLPGAQPPQEPLALVFRFGMTGSFQLVPRDALPPHAHLRFYTAPPSPQLALCFVDIRRFGRWELGGEWDPGRGPCVLLEYEQFRENVLRNLADKAFDRPICEALLDQRFFNGIGNYLRAEILHRLRIPPFEKARTVLEALQRHRLSPELTLSQKIKAKLQNPDLLELCHSVPKEVVQLGGKGYGPESREEDFAAFRAWLRCYGTPGMNSLRDRHGRTIWFQGDPGPLAPKGGKSRKKKSKGAQQGPEDRVEDPTLQNKATLRTRRTQRGLEQSTAQQPKGTSLQQDPETPLVPEKGKRRRRQATSGRRRPQKITGDTPSLEPEGTSAS
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGTVSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQYTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAVLAVQGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLGARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRGLRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGLALIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR
The following text describes a protein:
Function:
Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'-TTCTTTGTTY-3'.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Accumulates in the nucleus under conditions of nitrogen starvation and in the presence of mating pheromones.
Sequence:
MSASLTAEQKDQKSSVKRPLNSFMLYRRDRQAEIPTSNHQSISRIIGQLWRNESAQVKKYYSDLSALERQKHMLENPEYKYTPKKRSTVRRRHKKVSPSSGSFVASDYVVLQQIAQSSKTLKQTEPEKPVNEEETLAALLAPALSYPKSGKSNLIETSELSCLSSSPMIRSHTIPSLSFTDQVSTTISTLDKSEQAPSSLGIYYRSPSSGSPIGRTKSVCLANKARIVPKRSMSSDGCVDKSYQMSKTPSLEANLPQNSSNCSARRVPKFDSKGTVSEQSNSDSPELSADKVLSHCSPIDARPSTPSCPNASISPKTPNTGDHYGFDGAEYLGTPLSVGSTTAYLYGQETELLSTPYCHTSYPAMSRLNSSSGYTCVSSSSVTNSGHTENNTWRSDEQSKGFVDINSFSQSLFSNGNYEFAAHSQELDDLFSQITDFTSTDPIASSLKDANSLGPSLLEPWLPNSNLF
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MADAPPPATPAPLDRDVWLACATPLSRVPAVGSQVYYFPHGHSEQCPAPPRAPAHSLFPCTVAAVRLFADPRTDEPFAAVDLVPGPHRDPAPALPDADADAATGFRYYAKQLTQSDANNGGGFSVPRFCAELVFPPLDFEADPPVQRLRMTDPLGRGWDFRHIYRGTPRRHLLTTGWSKFVNAKLLVAGDAVVFMRRADGELLAGIRRAPRYPAVSQQGAERRPRNARARVPPEEVDEAVRLAAEGAPFTVTYYPRQGAGEFVVPKQEVEDALVGAWAPGVQVRMKFLGAEERRSEWVNGIVKAVDPSIWRMLEIDWDESVVGSLRNRHVNAWQVELVGYPPILKKLKISETILPPMCSGDVSVADPLLGPDCENMVMLLGSPIPAGMQGARHIGLTELPSPSPTVLTTKQFFPPSSSGGSSEVVNPEAGSPPNNSVNMRPSEERRSIQLFGATITSPVQSATNGSSEEVSQAPDAAVDGTAHEDACATSLLDCQLTIGKDDGHDRDGSKQQA
The following text describes a protein:
Function:
Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with SGS1 and TOP3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response. Required for resistance to the DNA-damaging agent methyl methanesulfonate (MMS).
Miscellaneous:
MISCELLANEOUS: Present with 1500 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFSSILSQDITDDITPPAYSATLGSREQIVFRAYQNEPWLAGTASNLILDKKLVIVDRELLFQVLMVENITKSKLTQIDDIKTKLDPKKQKVDRLRSGAQGNGAKKYEVITQVDMEDDGNVADNNCAKENNSNNNSSAAKNKAVFKLTLQSKSGDVFFAINSTPISWSSCMLGSKIVILPGTVFNRGVFILKDSQVIFLGGINRVWNENRDQKFCDYLESKLQRDKQLVNGGSKKRKAND
The following text describes a protein:
Function:
May negatively regulate the snf1 kinase.
Subcellular Localization:
Cytoplasm.
Sequence:
MGNTIGKERQENDEELIQHLVQLVDGGFLDPQGVYSSAPAYKTNIVRKLMLERRLMPFYKGLDSYSKDWPADKVVEVVEKALGPHKSALLHCAIRQSRSLSVGNTRSLKRDSRGSSDHLLTRNRSNSTPGSISADYRTTAITTIYANAMECPICFLYYPSNFNYTRCCAQPICSECFVEIRRAEPHLPTVHANEPTPNEFDLISEPAKCPYCMTERFGVIYKPNPKLTPFSFNNNPDTLPSNIAPMGTLSKSSLPLHHIPWPPNQHIKFAHDDKNVVSTDFIHPDWQYKLERARRRALRRAANATLLNSHLLETGPANANANHNTDLSHDPTSHGGPRRTLSSRRQHYLANVEQLMLAEAIRQSLLDAQSNDSTNSLPSTEVSQPDSTNISNEQEIVQPQPTHTTNVALVEEINRPDSVESAITASSSIDTGNENETQEVNSDSLPQFVHQTMTQTNFQESSPSVAADETRVHNVDEYIEQQDLDELIHSPIASTNPFLADQFARSETVDLNAHICSPALSVSDDGVTATNKTQSSFPSVYEHQLKSNELERGH
The following text describes a protein:
Function:
Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.
Sequence:
MKGLLLIVSLALVVLYYFNFQPGLNSRKTYEYNYEGTVRIGHVEKNMVESGLKISCSVEISGIADHTFLLKVINLSVEELNGIPGKSGFYSSPKLTDRISSQLTQPIKFEYIRGQIKDIYAAPNVSETVVNIVRGILNFLQVTVKNTHAVYQLEELGIHGFCHTSYVIEKDKKSKEIYITRSTDLRNCQEKAEKYIGLANAPKCKNCKEKGSQAEETVTYTYTMKLTDEGALITEANVQEMHQFTPFNVKEGTSLLEATKTFVLVNVKDAQGKPPKILLQNKGNLKYKFGSELNQIPLVLMKMENPEFKIAELIQRLVQANTQQIDANSTTDILKLYQVLRGSTIANLEAVWKKSSDDTNKRRWLLDSMTAISDTKIITFVKNRIRNKEITPNEAGQALLVILNKITPDSEAVEQSREFLETTFNKNHSVLWRITMLAYGSLIYRYCVNSEHCPGNALQPLHDLALDALSNGNEEDMILNLKALGNAGQYASMKIIMKFLPGFASGASQLPTRVQSNAVLALRKIAIKDPKSVQDIVTKIFLDKNIHAEVRMFACLVIFEAKPSMALVSTITGYLLKESNLQVASFCYSQIEALARSVTPDNQELSIACSAAVKILRPKLAHLSYRYSKAFHFDWFHDPTLSGIAADLYMINNAASSLPTAVVYRFKSYFIQRVIQPLEIGLRAKGIQELFNKNPLPINGRPGRIEKILQMLSGWKAIPKETPLVSGYVKFFGQEVFFADINRNMLYNSMQTLSTMAGKQNNTLKIIEDLQNGMALHWTKPYLIFETRYIQSTSLGLPAEISKYYSSMMGVFINAKAKFDPVPSNHLGQLMNSNIDLQADGSISIIKDFSCFHGINTDIVQAALQFDGKANVVLPFKVKIKMNIKEGKFQIDMPPCQRENEIMSVSSQVFAISRNREDSASKKTPVVVVPDTRESEKHNASSNEASRKPKKKLVCFYLCFSKEEITSTNLQLKSGDKMYREEAHLCVKANTFGMEVCLETKARNAFFLNRCPFYYLLGENYIKLKLKPVPTDGTIQKISIKMNVGSDQESQRLNQMMIDALNSLKKQSSNSTRSISSSSSSSGSSESYQKGQYAHKSRQWHRKNPSVSSSSSSSTWEPRHGRKRPHWSKSRVLRTDRNSTGSSSSSSQESSNQYHSLYNYRKGLILMYMMMMIYSSYPGLRRSGMADQYKIASLLQSRVFGKSSQPTVTFQAVVVRSNAKQEGYVATACISHTTTKDKMKLLISDVNKESKWKMSTDAVMDMDPLRTKVQVRWGEDHWKYKFAGEARYVEKCGSYPSVKAKLQWEKVPRFMKTFGEKVHEYLPGIALLLQCYQKQQRNPSHQVSVTLMPTSSSAMFDVILKTPGLTVYGYTIPLPFEIPTHRRSKEEIDLKPSGCTDVDEILIIRINLNECSVTGNNFKTFNNIKFTSLLPKACYHVLAQDCTDDLRFLVLMKQETPNKKEVNIRTPFGSLNIYHTGAGDLVLTLNDSPMLLSTLPLKDSSGTLLISKHGDGILVQAPTLGLGSLYFSGESVKVEIESWMRGKMCGMCGKADGEKKTEFRMPSWNTAMNPSSFVHSWILQGEVCSDVSVCKLQHQTVKLEKHVSLMGRESNCYTVEPVLRCRPGCSASDTVHISVRFHCVPLDHNLSQTEIVTKSEQMEGMTEAHIACICSGTECS
The following text describes a protein:
Function:
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAEQEKPKEEHAPINFDENHEEKRDFVISEGLTTAEAEELIKVHGRNELEEKHTPSWLIFLRQLYQPMPIMIWIAAIVEGAIENWADMGILLGIQFINATLGWYETTKAGDAVAALKASLKPLATAKRDGKWANIDAGNLVPGDLVLLASGSAVPADCLINHGTVDIDQAALTGESLPVTMHKGDSAKMGSTVVRGETEATVEFTGKNTFFGKTASMLQQSGGELGHLQKILLTIMFVLVVTSFILCGTAFGYLLGMGEPFKEALSFTVVLLVASIPIAIEIVCTTTLALGSRELSRHGAIVTRLAAIEDMAGMNMLCSDKTGTLTLNKMAIQDDTPTYLPGLDQRKLLHLGALAAKWHEPPRDALDTLVLTCETQDLSALDVYEQIDYMPFDPTVKRTEGTIKDKRDGTTFKVTKGAPHIILKLTHDERIHHMVDETVAAFGQRGIRCLAIARTLGDDLNTWHMAGLLTFLDPPRPDTKDTIHKAMAYGVDVKMITGDNILIAKETARVLGMGTNIQDPKSLPTMDAEGKAPKDLGKKYGKIIMEADGFAQVYPEHKYLIVEALRQNGFACGMTGDGVNDAPALKRADVGVAVQGATDAARAAADIVLTEPGLSTIVHGIVTARCIFQRMKNFINYRIAATLQLLTFFFIAVFALPPIDYPQGMWPTCNTPAAVGSPTCCPETYTYDNVTSTVTMEWLRDNQGNDEIANNLNGVCFTDGEPWPDFFKMPVLMLMLITLLNDGTLISIGYDHVKPSAMPEKWNLPALFAISIVLGMVACGSSLLLLWAALDSWNTNGIFQKWGLGGMPYGKVTTIIYLKVSVSDFLTLFSARTHDGFFWSARPSPILMGAALLALSLSTILACVWPKGHTDKQLSMGLAYETDPHSNTLMPLWIWIYCVFWWFVQDFMKVAAYWMMHRYNWFDINTSMAINKRDANKVDDRHDPLARGSVGLVEGKLLAAKVEEAQAKVNAAIKHDQATNLGRASANLGRVSANLKQAGMARHSGNPKGADVEGAAQTVENVLLHLDEARGELDPKVQQEIAPAIEGVREAAEKLAANTAAALGGANPEQTLAKISSKRHM
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLATYIVLFILASLILGETLVFLGIWFHISFQESIIVALSHLHKGKGPLIVTRIRILMFCVLLYWVYSTSVIFYSRWIFHGPINWRDDVALYLLILQASLLGFSLFAWMLLDKLYPVIMEHHSVRKIIKAEEILLQERKLLMGDHSRVLQGKIAELRAKMKKLETDCKIKATKAQAAGAIVLKLKNQFEELHFKYDRLFEYNQTLRNQLQSISHEVEINDESDGWSNLKIKLGCPTLENNGQSVDFKNVMEATTKCGEYLVSDTQSSSSPRHRRPIYQC
The following text describes a protein:
Function:
Functions as a positive effector of cell expansion through modulation of auxin transport (By similarity). Involved in thermo-responsiveness of plant architecture. Enhances plasma membrane H(+)-ATPase.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MALVRGFMAAKKILGGSVAGTRKETSAPKGFLAVYVGESQRKKQRHLVPVSYLNQPLFQALLIKAEEEFGFNHPMGGLTIPCPEDTFLTVTSQIQG
The following text describes a protein:
Function:
Component of the Yop secretion machinery.
Sequence:
MSLLTLPQAKLSELSLRQRLSHYQQNYLWEEGKLELTVSEPPSSLNCILQLQWKGTHFTLYCFGNDLANWLTADLLGAPFFTLPKELQLALLERQTVFLPKLVCNDIATASLSVTQPLLSLRLSRDNAHISFWLTSAEALFALLPARPNSERIPLPILISLRWHKVYLTLDEVDSLRLGDVLLAPEGSGPNSPVLAYVGENPWGYFQLQSNKLEFIGMSHESDELNPEPLTDLNQLPVQVSFEVGRQILDWHTLTSLEPGSLIDLTTPVDGEVRLLANGRLLGHGRLVEIQGRLGVRIERLTEVTIS
The following text describes a protein:
Function:
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections. The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units. The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone. However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C. Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B. The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin. Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin.
Sequence:
MPKTAFITGANGLSGSAIVEYLCNTTTSDDWGSIIVTSRSPFKSTVMDPRIKFIALDFVNDVSSLVETMKEVCGAVTHAYFCSYLHKDDFAESYTVNKALFENFIAAIDKAAPKLENVTLQTGGKYYNLHVEPVPSPARENDPRRYGPFENFYFTQEDTLAEMQRGKTWSWNVIRPEAIIGANSQPYGLNVALTIAMYFLICRELGSASPMPTNQRYWEGTDDVSYAPLIADLTIFVSTRKSCANEAFNVTNGDYFTWRYMWPRLAASLGAKADSQQCFEKPMPGEGELQLDWSLAEWCKDKRKVWEDLCDRQGLPGAKATFDLAGWAVGDFLYQRTWSATLSVNKARRFGWTGHMDSYQSFVDTFDKFRQLGLIPK
The following text describes a protein:
Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Sequence:
MPRIDADLKLDFKDVLLRPKRSSLKSRSEVDLERTFTFRNSKQTYSGIPVIVANMDTVGTFEMAVVMSQHAMFTAIHKHYSLDDWKHFAENHPECLQHVAVSSGSGQNDLEKMSLILEAVPQVKFICLDVANGYSEHFVEFVKLVRSKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGSCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIERNGQKLKLFYGMSSDTAMKKHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFG
The following text describes a protein:
Function:
SNARE required for protein transport between the ER and the Golgi complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MQSLNALGNRQIASLNADLSRMENGEGGPAIQGQITTTLSALSRLIDDYDSMARKEMVTVARDKANTRVARLKNEHKELKSRFEQAKNESQLKARQDLLGSSSSSSPYPSTASTSVSQRRAPNQSSFAESPFASSDPLFRPNHPPSSREDFALREHTFLQESENSIDQYIAQGRAVLGNLVEQKGMLKGTKRRLLDAANTLGMSRETIGWVERRTKQDAWIFGAGATFTLFSFWAIWYYLG
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MNKENNKGIKKPRDENNIHYKNALIKKKQQIEEKRKKKEQEQLIKGISQEEINETTYYFENGLRRVLPYFYTFKVNAKGRWIGRTIVDVFVHEFKLCNEETTIKKIEKGLIKINNKIIEPSTIIHHHDEIEHQVHRHEPPVYCDKLTIVKETNDFIAIDKPSSIPVHPCGRYRHNTVIFILAHEGYTNLRPVHRLDRMTSGILLLAKTIQAAREFQSYMTIKKKEYLCRVRGRLEKTTVTSKIGRKRIDDKKIHVSVNEIEEDGKECHSEFNPLFYDEKTNTTVAVALLGSGRTHQIRVHLQSIHHPIVNDPIYAAQFDESKCDDEGIFETQYGGTIQWKIEEGCIECEHLKGDPIQYGIYLHAWRYVIDDEIFETKLPYWAQPNVDISQEINEFNKNHILI
The following text describes a protein:
Function:
Possible role in vesicle-mediated transport. May be involved in proper membrane localization of Rab GTPases.
Miscellaneous:
MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPSNNSSFLDIDDDLEGVDDFGNEPNPFDDATVPDSPNMNNSTAGKGSEFYNTTGSKAESAPLQGQMDPPAYDQVIGQNDNDGLGRNGLRPGLINYYSKYFQIDLTQFKKRLSAVLTFRNDHNSESNEDNTDLYGAVWITATVVMINFTMSRGLNFIISDVIEGVKTGEDIDRASQFKKLLHSIWLFYGYTFGVPFITMQVLNRDEHSERNRSFKSVPELISVYGYANLIWIPVCVILNILDMSKRLRTVQAIQWAIVALGWAQSSYFLNSQISSNNNTETQSNGKFSLSIIVVVALHTLFCLLFRFIIF
The following text describes a protein:
Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MRNSKLKEVRNAWKHSRFFFGKNKVMALAFGRSPETEIMNGLYKFSTKLVNEVGVLFTSKSKEDVVDWFDKYSEHDYARTGNIATSTVELDEGPLVQFSHAIEPHLRKLGLPVALKKGVVTMLQSHTVCKENEKLTAEQAKVLKLLKIVMSQFSIHLQCMWEKDSGECSVFDVKEKEVMFNKVRVTTDDQVYDYVESEQKENMEVENVVKREKTVRRSLRIKNKSH