lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the phospholipase effector PldB to target cells where it exerts its toxicity. Also plays a role in VgrG4b and its effector PldA secretion.
Subcellular Localization:
Secreted.
Sequence:
MFAPANQTHFSLRIENLRHDFQVLAFRGREAISQPFRFDLELVSERSDLDLDALLHQPAFLILSPSGQGVHGQLTSIAQGDSGKRLTGYRATLEPRLAYLGLCSDQRIFQRLSVPEIIGRVLEGHGILADAYRFQLGPTPYPAREYCTQYDETDLAFLSRLCEEEGIHYHHEFSAQGHVLVFGDDQTSFPRLQRPVAYVQDAGLVADQPVVKRFGVRFDTRASRVTRRDYDFEQPALQMQAAHGPQPGAQQPDLEDYDYPGRFTHRERGKHLSHRALERHRADYLQARGESDEPALLSGHFLTLSAHPRGEWNDLWLLTEVLHEGRQPQVLEESIDSDVAQGQGDFRQGYRNHFVATPWSAHFRPPLEHPRPRVLGCQTAVVTGPAGETIHCDQYGRVKVQFFWDRLGQADDNTSCWLRVASNWGGKRYGGVAIPRVGMEVLVGFLEGDPDQPLVTGCLYHSENRVPYELPQNKTRSVFKTDSYPGGGGFNELRIEDRKGQEQIFVHAQRDWDENIEHDQKIRVGHERHDTVEGDSYSEFRAEEQRTVHADRKVELKAADHLSVADALHLRIGTGQFVEAGDEIHFKAGDKVVIEAGMELTLKGGGSFARLDPGGVTLDGAQVMINSGGSPGIGSGVRALSPLQPLAADAAAAGGALLGAIAQKIGEAPQKLLRFELSPLPGVASAARQPYRLYANGAFKEEGIADEGGAISFEPLPGERTYRIETANGHAYEVEMVDQPDALQADDRLAQQGFRDYRAEMPQHKPRSAPDAYRRDASRPGAADKDEPTP
The following text describes a protein:
Function:
Acts as a receptor for reticulophagy. Directs autophagic sequestration of folded tubules/sheets derived from the cortical endoplasmic reticulum (cER) and the cytoplasmic endoplasmic reticulum (cytoER) into autophagosomes. Is not required for the cytoplasm-to-vacuole targeting pathway, mitophagy, pexophagy, and non-selective autophagy.
Miscellaneous:
MISCELLANEOUS: Present with 1890 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Preautophagosomal structure membrane; Single-pass membrane protein.
Sequence:
MFNLILWPLFLLTSVAIPLQLTLEVVYLTSSVDFSKASAAKTATSLGQSPVVITIYKSLLKYWSLYEFIHFIYLYTPIDAFLNFLPFTSLLMSFGSICLTRELVYDFIAFMESQNKLTGFLNKITEPNFNSYLLFSSIYNIWFADDTNDKFLFGKLTQILISVTKRYEFPRTFYLAKVSDFLQNLILTRLRPFVTEQPQGDKNRYQNGDRESTKNGAAYQKSSQQSSSFEQNFTSTEFPNDYDFMEDILDETTELD
The following text describes a protein:
Function:
Involved in maintaining an adequate ionic strength homeostasis of the cellular aqueous environment, necessary for normal growth rate. Required for survival upon exposure to K1 killer toxin and hence plays a role in cell wall glucan synthesis. Required for dithiothreitol (DTT) resistance. Involved in cell cycle progression.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Secreted, cell wall.
Sequence:
MQYHSALYVYIYVTFTTIPYKEKPDIISICFSMLSFVFDFSVRICSRTLESFSWSLISSSAFKVVSAFSLAGSCVLASRSSVGIIVSLLLFNFSTCNFVLFLSAVLIDLFFCTFLPTPTFLPTPFFFMLHLPIFSLLNALELLYLIIAGLHI
The following text describes a protein:
Function:
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAEEPATNATELSEEEKFKRKFPNKKPMTTDVMRKRLQKGVKYFDSGDYMMAKSRDKNPRGPVNPAVLAVGKGIPTPDKIPHRKTSVPMTEHPVTQTVPTHPHQPHHTNVEVEN
The following text describes a protein:
Function:
May play a role in the developmental transition from cell proliferation to cell differentiation during neurogenesis.
Sequence:
MGALLALLDPVQPTRAPDCGGILTPLGLSYLAEVSKPHAEVVLRQDLMPKEPQTCSLAPWSPAGTELPAVKVADLWLSVIPEAGLRLGIEVELRIAPLHTVPMPVRISIRADLHVDMGPDGNLQLLTSACRPTVQAQSTREAESKSSRSILDKVVDVDKLCLDVSKLLLFPNEQLMSLTALFPVTPNCQLQYLALAAPVFSKQGIALSLQTTFQVAGAVVPVPVSPVPFSMPELASTSTSHLILALSEHFYTSLYFTLERAGAFNMTIPSMLTTATLAQKITQVGSLYHEDLPITLSAALRSSPRVVLEEGRAALKLFLTVHIGAGSPDFQSFLSVSADVTRAGLQLSVSDTRMMISTAVIEDAELSLAASNVGLVRAALLEELFLAPVCQQVPAWMDDVLREGVHLPHMSHFTYTDVNVVVHKDYVLVPCKLKLRSTMA
The following text describes a protein:
Function:
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNYTPYSSPAPGLTISPTMDPVTWVYFSVTFLAMATCVCGIVGNSMVIWLLSFHRVQRSPFCTYVLNLAVADLLFLLCMASLLSLETGPLLTASTSARVYEGMKRIKYFAYTAGLSLLTAISTQRCLSVLFPIWYKCHRPQHLSGVVCGVLWALALLMNFLASFFCVQFWHPDKYQCFKVDMVFNSLILGIFMPVMVLTSAIIFIRMRKNSLLQRRQPRRLYVVILTSVLVFLTCSLPLGINWFLLYWVELPQAVRLLYVCSSRFSSSLSSSANPVIYFLVGSQKSHRLQESLGAVLGRALQDEPEGRETPSTCTNDGV
The following text describes a protein:
Function:
PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus.
Subcellular Localization:
Secreted.
Sequence:
MAMCSKAIVVLLIYSIIMHDSIYCSPAGGFQLPGLRLEDEVYDEEGNSLQDLALDGSPLGVGSPSTLLTDVYTLYFPPDNRHTDATFNPAYRQPLGHYISARKSLRALIAQRAGGGSGVEGNWEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRDEDINTDHLLLYINTDALLQGDYETNDLGEFLKQILPLVSPLKRAALTQAYLQGATSLSLKISLSLMPL
The following text describes a protein:
Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MREPNLYVILSHALIGCGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDFWHGYEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRSGFNPMVQPMQFYLEFVWLMGGVTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKIYERPLARENFAFPFIFLQMFYLCICIGRIIHRQRHTSRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTSWNASALPTALVNAFVLDYSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRSRRLGHAQDLLNGDLFSLKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDICAHWALQVNVGFVAHLSACNPQYARVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRKSGAPVSALTEEQRERARKYVLEDFIEEHFVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRKEQPPARDDFMQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQEPGSGETETESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTANAQILNMHYVYSFLQMLVFTLIGLAVRKLFFLSFTQGCVIAPTVCSKLWYHRQRNIFWSVSLAVFLLSMFDPGMVNIREEYFPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRDDCDLLAIWDDKQPAYQKYPQFCHELLHKNVPSFLKVFANDHYGIIKMFSQSVQINLKHNKMPEMSI
The following text describes a protein:
Function:
May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKHEENRETVSSVSKILGLLLAASSCVFFAISSLFVKLLGEIPPQEVVFFRSLVQLIFLLPPVIYSQSPALGERRQLPCLIVRGLAGTLALCCQFYAFQRIPLADATVIVFSSPIFTGILGYFILREAWGWFDAVATMLCFFGIILIVRPTFLFGREAGGLSSSDNWQQLTASLVALCGAVMTSIALIAIRKLQGVH
The following text describes a protein:
Function:
Hydrolase that specifically degrades the potent antimicrobial compound 2,4-diacetylphloroglucinol (DAPG) to equimolar amounts of mildly toxic monoacetylphloroglucinol (MAPG) and acetate.
Domain:
Contains a small N-terminal domain involved in dimerization and a large C-terminal Bet v1-like fold catalytic domain.
Sequence:
MEARNMTPFTYFSLPMQKLFLRNQAAVRNKPYAKYFRSEMRVPLSAVRKIQQGPMALEDTLTPSIEDINRLLEPDFVSEESGYALLPGPMAYVQSRKFFPGCTAQMFKWWFIWHPAESERYTLWFPYAHVSNPCVHHQRLRDESLSFEERLYGNTFCASEYVGDRLMHLHIDFQQPASLGLNTDLYREAKIDGSVSALMSLADHPEVPVSLMVHLFKEVPDGMYLTSRYWVGAHPSMARFPGAEKAASLLKENGFGEAELETLAYEFAVHDMCEFNHLASFLPDLYREFGTPAA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
Sequence:
MSEIATMAQGEAGAIGPGRLVLVVGPSGAGKDTLLQLAQAACIDDHDVVFPRRVVTRESSAAEDNIAMSPDEFRRGIDHGDFAVHWDAHGHSYALPLEINDDIRAGRAVVVNVSRTVIAALRQAYANVVVVAITAPPDVLAQRLAARARHSDGNIAERLSRSVEDASAQADVTILNAGSADYHSRQLVRVIRNESWRE
The following text describes a protein:
Function:
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.
Sequence:
MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRFRNLIYVEFVGPRKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVRAKKPENCEKLVTLLENYKEMYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSDRDWDRRGRSRDMEPRDRWSHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAYESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLVQLAEDDGHSHMTQGHSSRSKRSAYPSTSRGLKTMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRSQRFPRMSDDNWKDISLNKRESVIQQRVYEGNAFRGGFRFNSTLVSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRKAMSVSSLSSLSSPSFTESQPIDFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEYGESFIHSVAVSEVQKSQVGGKRFECKDCGETFNKSAALAEHRKIHARGYLVECKNQECEEAFMPSPTFSELQKIYGKDKFYECRVCKETFLHSSALIEHQKIHFGDDKDNEREHERERERERGETFRPSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPGQSLKRRQKTYNKEKLCDFTDGRDAFMQSSELSEHQKIHSRKNLFEGRGYEKSVIHSGPFTESQKSHTITRPLESDEDEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASVEAQKSHSVAGPSKPKVMAESTIQSFDAINHQRVRAGGNTSEGREYSRSVIHSLVASKPPRSHNGNELVESNEKGESSIYISDLNDKRQKIPARENPCEGGSKNRNYEDSVIQSVFRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHRSNETSVIHSLPFGEQTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIRSLAPTDPQTSYAQEQYAKEQARNKCKDFRQFFATSEDLNTNQKIYDQEKSHGEESQGENTDGEETHSEETHGQETIEDPVIQGSDMEDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKVHSRKCLVDSREYTHSVIHTHSISEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYSMKGCDDGFIALLPMKPRRNRAAERNPALAGSAIRCLLCGQGFIHSSALNEHMRLHREDDLLEQSQMAEEAIIPGLALTEFQRSQTEERLFECAVCGESFVNPAELADHVTVHKNEPYEYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEDEAAAAAAAAAQEVEANVHVPQVVLRIQGLNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPIGEAGQPNGEAEQPNGDADEPDGAGIEDPEERAEEPEGKAEEPEGDADEPDGVGIEDPEEGEDQEIQVEEPYYDCHECTETFTSSTAFSEHLKTHASMIIFEPANAFGECSGYIERASTSTGGANQADEKYFKCDVCGQLFNDRLSLARHQNTHTG
The following text describes a protein:
Function:
Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase; Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
Subcellular Localization:
Cytoplasm.
Sequence:
MPVTDEAFVTLATSDVYCQGALVLGQSLRQHRTSRMTAVLITPQVSSSARAALARVFDEVVEVSGLDSGDLAHLAMLRRPELGITFTKLQCWTLTQYAKCVFLDADTLVLCNVDELFDREELSAAPDPGWPDCFNSGVFVFRPSLETYNQLLRFAMENGSFDGGDQGILNSFFGDWAVKDIQKHLPFVYNLSSSAVYSYRPAFRQYGHKARIVHFLGSVKPWHYKYNPQTRSAYQEPGFPVGSHPEHFVNLWWEVYSSGVVPLVMQHSERRESEQQHYACRSAVSEAKVRNESFLGEKKIKKRPVVFPCVHTPELASLPQPSAPEVEQQWETPEDLPREEVTVVEPEIQAPVPQHSPSETPAEDLVGHDRRNSIEHVTVQRLAKDRTDELPSPHLFHPLFKKDLKGVDLMATVSELSIDIKPELPVDTKPELSDSDHRRMWEEGRMDYMGEDAFENIQKKLDRFLE
The following text describes a protein:
Function:
Involved in the mitochondrial activation of MSD1 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVEAERAENSWIASETSPSSSPVVIESSDFSITDGMRDVSGFGIASRPQLDKGLSENNIGFTERVFSAAGAAVLSAVTLNPLDVVKTRLQAQAAGMSYSHPLSNSIGRMAFFGPNMMFADLRCSPSCARAGVEGTVSICPPDCFQYKGTFDVFTKIIRQEGLGRLWRGTNAGLALAVPMVGIYLPFYDMFRNRLEELSREKAPAMTFCVPTVAGSLARSLACTVCYPIDLARTRMQAFKEAKAGVKPPGVFKTLVGVFSEVRTANNLESSLHNYRGLWRGLGAQLARDVPFSAICWSTLEPIKKRLLGVAGNDTNLVGVFGATFSAGFIAGSIAAAATCPLDVARTRRQIEKDPGRALMMTTRQTLIEVWRDGGMRGLFMGMGPRVARAGPSVGIVVSFYEVVKYVLHRHASS
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MESKIGGEKIHKSMEWDSNEWRWDGALFVATPLNSVPSDCRSRQLGSDELVLLGDGNGNGREKRELEKRTRGVLEMEENESEDVGLPNLKLGGQVYPIAERDMYEMEGKSGKKTKVSSALPMSTSSRSVCQVEDCRADLSNAKDYHRRHKVCDLHSKSTSALVGDVMQRFCQQCSRFHVLQEFDEGKRSCRRRLAGHNKRRRKTHPENDEPANSSDQIQDQDLVSHLLKNLAHLTGTNPAGVLPISQNVGTSLGTALKGLSAPSGPGVTIPASDLTEKRTLIGGVSHASTSESPLPFRTTSSDLFKEKDSNTGVGRTKLSNIDLNCAYDGSQDCMEDMPNTSHLNKTSPGGSSWLCKDSQRCGPPQNSGNSASTSSQSPSTSSGEAQSRTDRIVFKLFGKDPSDFPLLLRKQILDWLSNSPTDIESYIRPGCIILTIYLRMEKSSWDELYCNLTSSLLRLLNSSTDSFWRTGWIYTRVHHHVTFMYNGQVVLDTPLPVRNHQSCRISSIKPIAVTVSEGVHFVVKGFNLSRSTSRLLCALEGKYLVQENCADMTGRADSLTEHDQIQSLTFSCAVPNIVGRGFIEIEDHGLSSSFFPFIVAEKDVCSEICSLESVIEDANEIQVRNEALDFIHEMGWLLQRNRLKSRLGDGDLFPFERFRRLTEFSIDHDWCAVVKKLLRILFDDGTVDLGPHNSNIVALLNDVGLVHRAVRRKCSSMVRFLLNEKNPLADGGGGAHLYLFRPDAAGPGGLTPLHIAASLDGCENVLDALTEDPGSVGIEEWKRGRDSSVLTAHDYACIRGQYSYINIVQRKVDKKSTVVGVGVDIGDSSSSRGEVVLSVSVDKKMEIERRRRRCGECEERIMRYGNRSTRGRVRIYRPAMLSLVGIAAVCVCTALLFKSSPEVLFSFRPFRWDQLKYGSQ
The following text describes a protein:
Function:
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Sequence:
MLIGSHVSPTDPLAAAEAEGADVVQIFLGNPQSWKAPKPRDDAAALKAATLPIYVHAPYLINLASANNRVRIPSRKILQETCAAAADIGAAAVIVHGGHVADDNDIDKGFQRWRKALDRLETEVPVYLENTAGGDHAMARRFDTIARLWDVIGDTGIGFCLDTCHTWAAGEALTDAVDRIKAITGRIDLVHCNDSRDEAGSGRDRHANLGSGQIDPDLLVAAVKAAGAPVICETADQGRKDDIAFLRERTGS
The following text describes a protein:
Function:
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably involved in the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MREASARAVAWSAAAGVLLVAVLLVSATIGPEPITLRTVAMAALTELAVPVGASVTMHTHAVPVVSGGLPWPALTIAYAAPLQFGVPETAQVIVGTIRLPRIVLGATVGASLAISGAVLQGFFRNPMADPSIVGVSSGAAVGAVAAITLPSVVVIGVQPAAFAGALIAAFTVYAIATKNGHTPTATLLLSGVAVQTLLGAVTSFLVVNSGREIRPAMYWLMGTLHGSRWHDVEAALPVVVVGSAVLLAYAREMNVLLAGEEDAHTLGVDVDRTKRLLLAVASVVTAAAVSFAGAIGFVGLIVPHAVRLVVGPDHRVLLPVSALTGGAFLVAADTVARATATEPPVGIITALIGAPFFLYLLRDREVRAL
The following text describes a protein:
Function:
Involved in mitochondrial fission. Has a partially redundant function to MDV1 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Plays a key role in determining the polarized localization of those DNM1 clusters that are not immediately involved in the mitochondrial fission process.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Uniformly distributed on the cytoplasmic face of the mitochondrial outer membrane. This localization is dependent on FIS1. Reorganizes to punctate structures on mitochondria, corresponding to mitochondrial constriction sites, at a late step in mitochondrial division.
Sequence:
MGSGDTRGESSLVAKPIEIILNKLPHAILAQQQFQKYITSPIYRYLSKLLLFREVAWPESTKDTQKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQRLLLDNVDGATNSDKEKYVQLPDINTGFVNKTYSRIDLTHLLEDVETNVENLSINKTLEMDELTRLDSMINELESRKLKILERVKHIDSKSTNLENDVTLIKDRINFIEEYNLEADREQSLRKQMEEERSSEASSFTQNEEAISSLCDVESKDTRLKDFYKMPHEKSHDKNRQIISETYSRNTTAFRMTIPHGEHGNSITALDFDTPWGTLCSSSYQDRIVKVWDLNHGIQVGELPGHLATVNCMQIDKKNYNMLITGSKDATLKLWDLNLSREIYLDHSPLKEKTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHWDLTTGKCIQQLDLIFTPTHSDIKMPARSLNNGACLLGTEAPMIGALQCYNSALATGTKDGIVRLWDLRVGKPVRLLEGHTDGITSLKFDSEKLVTGSMDNSVRIWDLRTSSILDVIAYDLPVSSLDFDGKLITVGANEGGVNVFNMERDEHWMTPEPPHSLDGDELSRRIAIVKYKDGFLINGHNDGDINVWTL
The following text describes a protein:
Function:
May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEELLFFFT
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
Sequence:
MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV
The following text describes a protein:
Function:
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subcellular Localization:
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Sequence:
MANQGQRVSWGDESTKTRGRSNSRGRKNNNIPLSFFNPITLQQGSKFWNLCPRDFVPKGIGNRDQQIGYWNRQTRYRMVKGQRKELPERWFFYYLGTGPHADAKFKDKLDGVVWVAKDGAMNKPTTLGSRGANNESKALKFDGKVPGEFQLEVNQSRDNSRSRSQSRSRSRNRSQSRGRQQFNNKKDDSVEQAVLAALKKLGVDTEKQQQRSRSKSKERSNSKTRDTTPKNENKHTWKRTAGKGDVTRFYGARSSSANFGDTDLVANGSSAKHYPQLAECVPSVSSILFGSYWTSKEDGDQIEVTFTHKYHLPKDDPKTGQFLQQINAYARPSEVAKEQRKRKSRSKSAERSEQDVVPDALIENYTDVFDDTQVEIIDEVTN
The following text describes a protein:
Function:
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Plays a role in beta-lactam antibiotic resistance via its role in generating anhydro-N-acetylmuramic acid-linked peptides; these peptides function as signaling molecules that induce high-level expression of the beta-lactamase AmpC.
Subcellular Localization:
Cytoplasm.
Sequence:
MGPLWLDVAGYELSAEDREILQHPTVGGVILFGRNYHDNQQLLALNKAIRQAAKRPILIGVDQEGGRVQRFREGFSRIPPAQYYARAENGVELAEQGGWLMAAELIAHDVDLSFAPVLDMGFACKAIGNRAFGEDVQTVLKHSSAFLRGMKAVGMATTGKHFPGHGAVIADSHLETPYDERETIAQDMAIFRAQIEAGVLDAMMPAHVVYPHYDAQPASGSSYWLKQVLREELGFKGIVFSDDLSMEGAAVMGGPVERSHQALVAGCDMILICNKREAAVEVLDNLPIMEVPQAEALLKKQQFSYSELKRLERWQQASANMQRLIEQFSE
The following text describes a protein:
Function:
Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Also plays a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MESLTKTEYVDAFLSNYSPNDSMSIFRQRLEQVRLDNDMLSQWIRERMDIERQYSDQLHKLAMNMQEKNNSSFAFNYAWKQLEGETLEISRYHSQIIGQIASQVYKPLIDYYTSSPQTATLRRLAERLSTVAEEMASSSVPGLKGLKKKGRDADTKSQNDLTASRATWDSDAPLAFEKLQIVDEERLLILKQVYLTIASLETDTALKQQEFFSKSMAVYSDLPIEGEIRQFMNSTSKVMSSASANKPSKSSGFHINNGKSKEEKSHGENESGGKLKNKMSTLFRRKTIMPKKDKKPSHKSNGRPNKLTAFFNKNSKASSISSAEEHPSNIDDSSIERRHYDSNHSSQIRDHPSTNNNASSYQNFNETSDEGEDNDATIRANNVRSSFLEAPLPVQPNVQAETVTPKISSKASPFNKPNSVHSEASRNTPSSIDRENASHSNPIMMHGNDFGGNFNNMQSRSTTTSPTSAVASPAPTENEDSNAAIERVANTLRKNPTISRRTRRAGTMDRYATASSDYMESNLGSLPNLSTLSLQSGPDSTATWHPEFPNSSGLSASIVEKYSGELSEDGLLHPSCSGHIFMKYTSDFNTPPPEMGVRVASEFPMSFTHLNDHAVKYGPSENTLSLIPELLLSPIKVTDFNLHLDSINGASCIPLTVVQKWKHDESSSSMIAFVKPNPVWRNLGSSLHIEKLVIIVYLGENVLVKSCQSSPAGEFSRKTSKLKLHLSNINISSSGFKILAKFAISPSAAIRKPVIEFRIRMVDSSNNPGLTKLFLKPDMFDTTSSSGGSQLESAYEETKVPTSYGIHVRECSVFADMS
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MESIDLNMDDIFDRGGGYESGEDVGYHADDRYRNENYDEGSSEVRDGRNVEAAGEGDEVLSNLKDVSKETKKRTIRPQIKLDVDKLKGSRGLQALPKIFKKVHLKGKGHEAHDLDLIMTHLEHWAHRLMPKIPFCEFVERMEKLGTRKEVQTCLKRIRLDLPFFDGAIEDSDDANKPNSPIYMNDEMMHAVDAEENDTEDHSRTNITETSPNHHGDSTSSSQARESSMAENNESNSWTIKNDSTNNIVLTESMKERIERNRQLALERRAMRMAGTLGSSQTVNKR
The following text describes a protein:
Function:
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVLKVFFPTCCASADSGLLVGRWVPGQSSAVILAVVHFPFIPIQVKELLAQVQKASQVPVAVLGTWCHRQQEPQESLGNFLEGLGTIFSHDPWLQLCRERGTRLWSCKATYPQMSNPLDMHPEEQVMLIFYDQRKLLLSWLHPPPVLPACQMGDTTASTGGLADIFDTVARSEVLFRNDQFDERPVRLSHWQSEGVEASILVELAKRASGPVCLLLASLLSLISAASACRLWKLWPLSFIRSKLSTCEQLHHRLKHLSFIFSTEKAQNPMQLMRKANMLVSVLLDVALGLLLLSWLHSNNRIGQLANALVPVADRVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLWISYIHLMSPFIEHILWHVGLSACLGLTVALSIFSDIIALLTFHIYCFYVYGARLYCLKIYGLSSLWRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILVFLLPTTALYYLVFTLLRLLVITVQGLIHLLVDLINSLPLYSLGLRLCRPYRLAAGVKFRVLEKEAGRPLRLLMQINPLSYNHVMHIYRLPRCGCHPKHSWGTLCRKLVFGELIYPWRQREDKQD
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSCFTFLKVMMVLFNLAIVIGGGVLLGIGIWVSVDSSSFLNMFGPLSSSVLQFVNVGYLLIAIGAVLFLLGFLGCCGAQKESKCLLMTFFSIVLIIFIVEVAAAVVALVYTSLAETILQGTVTQLLKNEYGKNTDITTVWNATMKDLKCCGLSNYTDFNNSYYMSQKHEYPSYCCEKDPCNEVEAEKSRVPGCFPQLLSEIRKNAGVVGGVAAAICALEIAAMAVAMYIYCRLDEK