lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN). Catalyzes the oxidation of L-aspartate to iminoaspartate.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATSIASGSAHLQFRETRCWRQTSFSPVVSQRCSNKFSWSYGLSNNLKIKKCHHHQIPETQRPFQTVVTSYMKNESTKYFDFAVIGSGVAGLRYALEVAKHGSVAVITKAEPHESNTNYAQGGVSAVLCPSDSVESHMQDTIVAGAYLCDEETVRVVCTEGPERIRELIAMGASFDHGEDGNLHLAREGGHSHHRIVHAADMTGKEIERALLKAIENDPNISVFKHHFAIDLLTSQDGLDMICHGVDTINTETQKVVRFISKVTLLASGGAGHIYPSTTNPPVATGDGIAMAHRAQAVISNMEFVQFHPTALADEGLPIPPTKSRDNSFLITEAVRGDGGILYNLDMERFMPMYDERAELAPRDVVARSIDDQLKKRNDKYVLLDISHRSRDQILSHFPNIAAECLKYGLDITRHPIPVVPAAHYMCGGVKAGLQGETNVLGLYVAGEVACTGLHGANRLASNSLLEALVFAQRAVNPSIQHMKESYTDHQTVSRWWDPPVVPMQLGSTILTKILKRTKQVRNELQSIMWAYVGIVRSTTWLKTAERRIGELELEWEAYLFQQGWEPTMVGLEACEMRNLFCCAKLVVSSALTRHESRGLHYTIDFPHVDEESRLPTIIFPCSMNTTWSSRQLHKQQIC
The following text describes a protein:
Function:
Forms the proximal part of the tail tube.
Subcellular Localization:
Virion. Note=Present in 12 copies in the virion (Probable).
Sequence:
MSSYTMQLRTYIEMWSQGETGLSTAEKIEKGRPKLFDFNYPIFDESYRTIFETHFIRNFYMREIGFETEGLFKFHLETWLMINMPYFNKLFESELIKYDPLENTRVGVKSNTKNDTDRNDNRDVKQDLTSNGTSSTDAKQNDTSKTTGNEKSSGSGSITDDNFKRDLNADTADDRLQLTTKDGEGVLEYASQIEEHNENKKRDTKTSNTTDTTSNTTGTSTLDSDSKTSNKANTTSNDKLNSQINSVEDYIEDRVGKIGTQSYARLVMDYREALLRIEQRIFNEMQELFMLVY
The following text describes a protein:
Function:
Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Domain:
The AP2/ERF domain binds specifically to the 5'-GCCGCC-3' motif. The affinity of this binding is higher if the seventh amino-acid of this domain is basic (By similarity).
Sequence:
MATPNEVSALWFIEKHLLDEASPVATDPWMKHESSSATESSSDSSSIIFGSSSSSFAPIDFSESVCKPEIIDLDTPRSMEFLSIPFEFDSEVSVSDFDFKPSNQNQNQFEPELKSQIRKPPLKISLPAKTEWIQFAAENTKPEVTKPVSEEEKKHYRGVRQRPWGKFAAEIRDPNKRGSRVWLGTFDTAIEAARAYDEAAFRLRGSKAILNFPLEVGKWKPRADEGEKKRKRDDDEKVTVVEKVLKTEQSVDVNGGETFPFVTSNLTELCDWDLTGFLNFPLLSPLSPHPPFGYSQLTVV
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MIEELRIKNFAIIDSLVVPLSKGFNVITGETGAGKSIIVDAIGILLKEKVPAVDFIKHGKNEANIEVIIYDTNEKESVFEDEALILKKILSIQGKTKTYINDSAFTVNEFVKIASRLINIHGQHEHTHLLKKENHILFFDTIAKLKQEVERFNQLYMDVQSLKQELEKISKEIALKKQRIELLQFQVAEIKNAKLKEGEEEELIEQRQILKNVLKLKELAESSFSLLYEDRNSVHTNLSKILNLLKELSKFDSKAEEVKSLIESALTQSEEAVYMLRKLKETYEPDPATLENIEERLTLINKLKIKYGSTIKEIIEYAKEAEKELNIISVSEEDLKTKENKLEKLLDEMISQANKLSAKRKSVKNKIEEEIINELKFLGFLHPLFEIKISEKELSLNGKDDVEFYFSSNPGEPPKPLIKIASGGELSRLMLALKCVELKLAKNSLKSMTLIFDEIDAGIGGTVAENIGRRLKELSNHHQVICVTHLPQIAAQAQHHLKVEKVILDNKTLVKIDVLTGIKRKEEIARMLSGRITESSIFHAEELLESK
The following text describes a protein:
Function:
Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Sequence:
MSAEAVKKLSFEIAPSEEESEATIEQQDVACGLENLPVSLWPLGAGPRPKPFQYTPDHVAGPGVDMDPTQITFPGCACIKTPCVPGTCSCLRHESNYNDNLCLRDVGSEAKYAKPVFECNVLCQCGEHCRNRVVQSGLQFLLQVFQTEKKGWGLRTLEYIPKGRFVCEYAGEVLGFSEVQRRIHLQTAHDPNYIIALREHTYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDILPGEELSYDYSGRFLNQISSKDKERIDCGQPRKPCYCGAQSCATFLPYDSSLYGPLENPGTS
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGEADPPLPPPGLRATPAQDGCGEFMPSLEADPADPSSLRCATCRCHRNFHRRLAELPRCAVRRRRTTACRPPSTRRPRRSRTRARISTRTARCRRYRARRARASKPPAVAPRPPPPPASASLGPMPPAPPETVVPGAAAARKRFRTKFSPEQKQRMQALSERLGWRLQKRGEALVDECCQEMGVFKVWMHNNKHNFVGGHNACRSASASAAAAAAIHHHPSNHGPGWELGLLRVRVRRRRLRLLPLPRGAATDGYGGEQAGRRG
The following text describes a protein:
Function:
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin. AP57 is probably a subunit of the Golgi membrane adaptor.
Miscellaneous:
MISCELLANEOUS: Present with 4420 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MASAVYFCDHNGKPLLSRRYRDDIPLSAIDKFPILLSDLEEQSNLIPPCLNHNGLEYLFIQHNDLYVVAIVTSLSANAAAIFTFLHKLVEVLSDYLKTVEEESIRDNFVIIYELLDEVMDYGIPQITETKMLKQYITQKSFKLVKSAKKKRNATRPPVALTNSVSWRPEGITHKKNEAFLDIVESINMLMTQKGQVLRSEIIGDVKVNSKLSGMPDLKLGINDKGIFSKYLDDDTNIPSASATTSDNNTETDKKPSITSSSATNKKKVNIELEDLKFHQCVRLSKFENEKIITFIPPDGKFDLMNYRLSTTIKPLIWCDVNVQVHSNSRIEIHCKAKAQIKRKSTATNVEILIPVPDDADTPTFKYSHGSLKYVPEKSAILWKIRSFPGGKEYSMSAELGLPSISNNEDGNRTMPKSNAEILKGPVQIKFQIPYFTTSGIQVRYLKINEPKLQYKSYPWVRYITQSGDDYTIRLT
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with cognate antitoxin RelB2 (shown only for M.smegmatis). Overexpression also increases the number of gentamicin-tolerant and levofloxacin-tolerant persister cells; In combination with cognate antitoxin RelF represses its own promoter. Has been seen to bind DNA in complex with antitoxin RelF but not alone.
Sequence:
MPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDHRADIYRR
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MPPPILKINRSIIMNSMKKIDHLSLDGHALELFLAVLEEGSVTAAATRLGLTQSAVSHSLNKLRRIAGDPLFAKSGRGIVATAHAQALAAKARALIDEMRSFAGGVSFEPAQAQLSLTIAANDFQRDLLLPRFFGHVSEQVKSLHLRVIPSQSPSPAMLRENRCDLMITPLPPSGVDIVQKRVLSDHYVCYFDPKARTAPAGRSAYLAARHITVVYTDNERLDFDRRLAANGFHRDIAISVPSFSGVPSFLRGTQMLASMPSLLASGVMQGFAHARIPLASGTRTLAELPMFMVWHQRYQKDPAHRWIRNQLETVAETAAGA
The following text describes a protein:
Function:
Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MKLVRFLMKLNNETVSIELKNGTVVHGTITGVDVSMNTHLKAVKITLKGKNPVTLDHLSVRGNNIRYYILPDSLNLETLLVEETPRVKPKKPTAGKPLGRGRGRGRGRGRGRGR
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MNYLRGAFKPACNISITFTDGKNRKQVPVKKDNGQMVMNPLFHSQETIAGKVCIEPYQGKKVEHNGVKVELLGQIEMYFDRGNFYDFTSLVRELDVPGEIYENKAYPFEFPTVEMPYETYNGVNVRLRYVLKVTVTRGYAGSIVEYQDFVVRNYSPLPPINNSIKVRSKLSQFPGSLSLFILNPFALKPLLASDMLNSFGPLLDVQMEVGIEDCLHIEFEYNKSKYHLKDVILGKVYFLLVRIKIKNMDLEIRRRESTGAGANTHVETETLAKFELMDGAPVRGESIPVRLFLTPYDLTPTHKNINNKFSVKYYLNLVLVDEEDRRYFKQQEITLYRLKDESS
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAPPKLSLLALLFLLFPAAGNAAAAAAAADPADTVAAAAPPALFNVTEILGRFPDFTLFNYLLTKTKVSAQINRRGTVTILAPVNADVDWLLRRSSRLPRAALVELLAVHVILDYIDAAKLAALPRGRPGAPPVVATTLYQTMGVAPAGDRSGFLTITPTGNGGAVFASAAPGALVNAPFKKAVTAKPYNISVLQISNFVVPPGVISRPRFGPPPPRRIRSMAVAPSPAPAPVLPAVPPVTMPVEEGTTETIPVAAPEPSDGNRAVEAMRLWFGAGVVMALACVLVTGL
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MKDLLNMIGDGVFSRFESSLKKKNSTSKIKSSFADSSNLKTQSNLTLKTQSASASEKKISVNTEVVGSVYSVTTGSHSILASSLFQKLNQTILVVSENNTSAEFLFREALSFLPSNDLIYLPGQEVLPYEYMRYPSEMKRERIKAIAKILSGEPVLIFTSVSGFLKTLPPIQTMQGRAIVLKKGKEIDLESLLIQLIDLGYKRVQVCETFGEFSLKGGILDIFSSYSTEPVRIDLFGEEIESIRTFDPDSQRSMTDLDQAVLLPADEYILSEEQKKEYQNFLKSSDSSLHLPEIPEGNYGIYYEELIPLVRENHGILSYFSEPPILIFPSANSVKERLFHLEKEYLSLFEKRSREVLCAPPEKLLSFGEEFKVLSESIGLSFVGLPPRNENDLVSLLKEAPSFKGKIREVREKISELRAKGGWKIVLTSSFEAQTKRLQGLFEKEGVILLNEDSTEPLPFHLGNHKSDTFLVLSELRNGFILENQKILILSENDIFGREYKRKTRFKKQNSKALQSFIDLKEGDYVVHIHHGVGKFLKIERTSAGGKERDFLKLEYSGGDSLFVPLDQISLVQRYIGGTESPRLDSLGKSTWKKTKDRVQKAVEALAEDLVQMYSNRLKLQGYAFPPDTIYQEEFEAEFEYEETPDQIEAIEAVKKDLESSRPMDRLVCGDVGYGKTEVAIRAAFKVAMAGRQIMMLAPTTILALQHYNTFKNRFENYPVRVELVSRFKTPAEIRDILADFSAGKVDMVVGTHAILSSKLKPKNLGLLIIDEEQRFGVNHKETIKKFKNLVDVLTLTATPIPRTLHMALTGIRELSIIATPPKNRQSVETYVLEEDDDLISDAIRNEIQRGGQVFYLYNRVETIEEETNYLSKLVPEVSIGILHGQMTEDEIEETLLDFYNRKYDILVTTTIIESGIDMPNVNTLFVKRADLFGLSQLYQIRGRVGRSDRKAFAYMLLPKDRVVTEQAEKRLNTIFEYQELGSGFKVAMRDLEIRGAGNLLGKEQSGDIMEVGFDLYVRMLEDAIARIKGEEIVVEVRTSVTLNTNFFIPETYISDTRQKIEFYKKLEGARDLDEIEEIYSEMLDRFGEPPEDAKTFILLEKIRTLASNLGFEFVTEMKDEIKMKSGSYFRGDHTKIIQLISARTGLTLNPKEPNVLIFQTEKKLEKEKLDTLIFLLSEMLPSKKV
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MVATTKRKRLGVSKNRKKTWVKHSDIKDIEGFLEDQRLDERLGGAVSTKPDEELFYVDKSPAAPKPKRAVQSKRERRNRKLTCYLNLEPSSKVAPPTKPRRVRDPEERKPAAVRRVQQQRLAKRHEQAVTQRLRSVARKAKQANGHSDFTGLRDIWADEEKKADSGLDPELETYIAEYTKERRPNIPAHRYQKPSLLPAVQPPHPGASYNPAPDAHQELLHEAFLIEQKRLKEEQHIDRVLTKMLPTRETMPTEEDMIAEMSQGLYDDPSSDEAEGDEVAGDDGARSGQANPPVRAEDRKTKQKRRRELEQKRIQSAAKVRKTERVLANQVYRIPTIKAELRREAEISEERQKRRQEREDDKLYQANRLSKFKFEEPDMELKLPEELTESLRQLKPECNVLEDRYKSLQKRNVIETRKRQKKVRKYKPKKALKREHRLFKEAEEKKWRERIQ
The following text describes a protein:
Function:
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW (By similarity).
Miscellaneous:
MISCELLANEOUS: HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion.
Subcellular Localization:
Secreted.
Sequence:
MLLQGALLLLLALPSHGEDNMEDPPLPKGACAGWMAGIPGHPGHNGTPGRDGRDGTPGEKGEKGDPGLVGPKGDTGETGITGIEGPRGFPGTPGRKGEPGESAYVYRSAFSVGLERQVTVPNVPIRFTKIFYNQQNHYDGTTGKFLCNIPGLYYFSYHITVYLKDVKVSLYKNDKALLFTHDQFQDKNVDQASGSVLLYLEKGDQVWLQVYEGENHNGVYADNVNDSTFTGFLLYHNIVE
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity. Can interact in vitro with palmitoyl-CoA, but not with oleoyl-CoA. Binds to lead ions (Pb). May function as an intracellular carrier of acyl-CoA esters. Required for proper phospholipid and, to a lower extent, galactolipid composition.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Sequence:
MGDWAQLAQSVILGLIFSYLLAKLISIVVTFKEDNLSLTRHPEESQLEIKPEGVDSRRLDSSCGGFGGEADSLVAEQGSSRSDSVAGDDSEEDDDWEGVESTELDEAFSAATLFVTTAAADRLSQKVPSDVQQQLYGLYKIATEGPCTAPQPSALKMTARAKWQAWQKLGAMPPEEAMEKYIEIVTQLYPTWLDGGVKAGSRGGDDAASNSRGTMGPVFSSLVYDEESENELKIDAIHGFAREGEVENLLKSIESGIPVNARDSEGRTPLHWAIDRGHLNIAKVLVDKNADVNAKDNEGQTPLHYAVVCDREAIAEFLVKQNANTAAKDEDGNSPLDLCESDWPWIRDSAKQAD
The following text describes a protein:
Function:
Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.
Sequence:
MFRSVIAQQRFVLPRLAIHPRISRSILFCPSNSFHSSSQCLAKRKNKKSSNKNDEELDSSEKADENAEVTIDFQKVTSNFDNVLSKFNKAATDIKLGKLNPKIFDNLEVNIGNHGHEELVPFTSVAQTSVKGRNFIINLFDAGYGKHVINSIIGSGLNMSGTIDPTNKFQIKVPIPNITTETKQENIKQLKEIFENLKNNHKSNSLNYVRSEARNKFQSSLKHNKISDSQHQLLKKLETLHKTYVDKLTDAFKQAEKSILK
The following text describes a protein:
Function:
Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy metals such as Cu(2+) and to arsenite.
Subcellular Localization:
Cytoplasm. Perikaryon. Cell projection, axon.
Sequence:
MENVCFQQRLRDLETRVRKWKFLKLGLTEVRLRPRDRRSTSVDQKHKECSSTSSSPQHQRPNNIGYLTSPMERKFTPLSMKPSPSRRDTEKDALEYEFLEGYKKSGTLEIDGEKQVVDPNEIHIISLLGSGSCGVVESATVRSKLMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTGLYPFPLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFYLDYDPASGSAYKFKAINGKCNQVADWFVDVIRLSKTEDELKSIPNTPCVN
The following text describes a protein:
Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSSPLASLSKTRKVPLPSEPMNPGRRGIRIYGDEDEVDMLSDGCGSEEKISVPSCYGGIGAPVSRQVPASHDSELMAFMTRKLWDLEQQVKAQTDEILSKDQKIAALEDLVQTLRPHPAEATLQRQEELETMCVQLQRQVREMERFLSDYGLQWVGEPMDQEDSESKTVSEHGERDWMTAKKFWKPGDSLAPPEVDFDRLLASLQDLSELVVEGDTQVTPVPGGARLRTLEPIPLKLYRNGIMMFDGPFQPFYDPSTQRCLRDILDGFFPSELQRLYPNGVPFKVSDLRNQVYLEDGLDPFPGEGRVVGRQLMHKALDRVEEHPGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPARIQEIVVETPTLAAERERSQESPNTPAPPLSMLRIKSENGEQAFLLMMQPDNTIGDVRALLAQARVMDASAFEIFSTFPPTLYQDDTLTLQAAGLVPKAALLLRARRAPKSSLKFSPGPCPGPGPGPSPGPGPGPSPGPGPGPSPCPGPSPSPQ
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MEAETSWTNYPYSYITYVPEAESYREQSDDEAKVETFSMDSLLPDDLLERILSFLPIASIFRAGTVCKRWNEIVSSRRFLCNFSNNSVSQRPWYFMFTTTDDPSGYAYDPIIRKWYSFDLPCIETSNWFVASSCGLVCFMDNDCRNKIYVSNPITKQWRTLIEPPGHKSTDYTAMSTSVNRANQAVNRANRSYSVSIVKSKQVPGNFFQWDLSIHLYSSETMTWTTLVNDVLSGWRGGNESVICNNVLYFMIYSTGGSDHRHGLIASNLSSIGSPSSGILMRSFIPMPCSLTCGRLMNLRERLVIVGGIGKHDRPEVIKGIGIWVLKGKEWVEMAKMPQRFFQGFGEFDEVFASSGTDDLVYIQSYGSPALLTFDMNLKYWRWSQKCPVTKKFPLQLFTGFCFEPRLEIAP
The following text describes a protein:
Function:
Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes. May catalyze ubiquitination of target proteins in complex with RMD5 (Probable). Required for survival upon exposure to K1 killer toxin.
Miscellaneous:
MISCELLANEOUS: Present with 784 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEKSIFNEPDVDFHLKLNQQLFHIPYELLSKRIKHTQAVINKETKSLHEHTAALNQIFEHNDVEHDELALAKITEMIRKVDHIERFLNTQIKSYCQILNRIKKRLEFFHELKDIKSQNSGTSHNGNNEGTRTKLIQWYQSYTNILIGDYLTRNNPIKYNSETKDHWNSGVVFLKQSQLDDLIDYDVLLEANRISTSLLHERNLLPLISWINENKKTLTKKSSILEFQARLQEYIELLKVDNYTDAIVCFQRFLLPFVKSNFTDLKLASGLLIFIKYCNDQKPTSSTSSGFDTEEIKSQSLPMKKDRIFQHFFHKSLPRITSKPAVNTTDYDKSSLINLQSGDFERYLNLLDDQRWSVLNDLFLSDFYSMYGISQNDPLLIYLSLGISSLKTRDCLHPSDDENGNQETETATTAEKEVEDLQLFTLHSLKRKNCPVCSETFKPITQALPFAHHIQSQLFENPILLPNGNVYDSKKLKKLAKTLKKQNLISLNPGQIMDPVDMKIFCESDSIKMYPT
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin ParE2.
Sequence:
MVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAAPADDNIFRILVATDMHLGYAKNDPTRSLDSLETLQEVLELAIGNNVDFMLLAGDLFHDNQPPRFVLHQTMTLFRQFCLGDRPLRFQALSDPTDSIKTAFGYNFEDPNYNVSLPVFSIHGNHDDPQGDAGLCALDLLSSANVINHFGQVMDLDKIHVVPICLQKQNTKLALYGIGSIRDERLHRIFLERRISFAQPEGDNWFKILVIHQNRVKHGEKNYIPESFLPADMNLIVWGHEHKCEIEVVSQENRPAITQPGSTVATALSAGEAEPKHVGILEVALRGEDPSSLQPKYRLKKKPLRTVRPFEFADMVHELIRRSAENYQARFGDADAIKLPLIRLRVDYSGGYPTISSQRFGQKYVDKVANPKDILLFHRRKLRSTSNIQGSATDPIDDRPLRPDAAQVAISDLLQLDRMQLRVLRPEGLRRVLQKFVEHEENSAVAEYVKTELIQQRHLSEDLPEVDELRPAALEDPPPTSAAGSSRTSRAAQAGGTRNSINAAPRQRGGSRASASLTVQRASDATPMSANDAAPIFQRAAARQRRQPVEKRGASPTSHGATSDDAMTTRHSDVEDDEDHMDSDDAASLAPSAVTHVTDISQVSRIGASTQYLRTQGKRDDGLLDQESDDEDYQARRRSRKRSKRR
The following text describes a protein:
Function:
Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3-hydroxyacyl-CoA species through addition of a water molecule to the double bond. Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (By similarity). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (By similarity). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation. At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAALRALLPRACSSLLSSVRCPELRRFASGANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEQDPAVGAIVLTGGDKAFAAGADIKEMQNRTFQDCYSSKFLSHWDHITRVKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVEKLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGNKLEKRLFYSTFATDDRREGMTAFVEKRKANFKDH
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
Subcellular Localization:
Cytoplasm. Nucleus speckle. Endoplasmic reticulum.
Domain:
The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins; The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Sequence:
MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKPNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALRLFITYVDSPFYTFFLVFLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM