lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Microtubule-dependent motor protein involved in the control of the oriented deposition of cellulose microfibrils. Involved in wall biogenesis and modification, and contributes to cell-cycle progression and cell division. Acts as a transcriptional activator in gibberellic acid (GA) biosynthesis pathway. Binds specifically to the DNA sequence 5'-ACCAACTTGAA-3' of the ent-kaurene oxidase 2 (CYP701A6 or OsKO2) promoter. May regulate CYP701A6 gene expression and mediates cell elongation by regulating the GA biosynthesis pathway.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Note=Associated with mitotic microtubule arrays during cell division.
Domain:
Composed of an N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule) and a central to C-terminal alpha-helical coiled coil domain that mediates the heavy chain dimerization.
Sequence:
MTMEHGEDCCVKVAVHVRPLIGDEKLQGCKDCVSVVSGKPQVQIGSHSFTFDHVYGSSGTPSAAMFEECVAPLVDGLFQGYNATVLAYGQTGSGKTYTMGTACKEGSHIGIIPRAMATLFDKIDKLKNQVEFQLRVSFIEILKEEVRDLLDPATAAVGKLENGNGHATKLSVPGKPPVQIREASNGVITLAGSTEVHVTTQKEMTACLEQGSLSRATGSTNMNNQSSRSHAIFTITLEQMRKADPIMTLDGMPIEEMNEDYLCAKLHLVDLAGSERAKRTGSDGLRFKEGVHINRGLLALGNVISALGDEKKRKEGAHVPYRDSKLTRLLQDSLGGNSKTVMIACISPADINAEETLNTLKYANRARNIQNKPIVNRNPVADEMKRMRQQIEYLQAELVSARGGVVLDDVQGLRERISMLEQKNEDLCRELYDLRNHGYTDPCEPELQKIGTGYTKGEGLKRSLQSTEPFDVPMTDSVRAGSPKDIDDEVAKEWEHTMLQDSMGKELNELNRQLEQKESEMKMYGSDTVALKQHFGKKLLELEEEKRAVQQERDRLLAEVESLNADGQTHKLRDAQLQKLKTLEAQILDLKKKQENQVQLLKEKQKSDEAAKKLQEEIHSIKAQKVQLQHKIKQEAEQFRQWKATREKELLQLRKEGRRNEYERHKLQALNQRQKLVLQRKTEEAAMATKRLKELLEARKSSGRDNSGMNGTSPGSHMTEKSLQKWLEQDLEVMVHVHEVRNEYEKQSQLRAALGEELAILKQEDVMSGAASPPRGKNGNSRANTLSPNARQARIASLESMVTISSNTLVAMASQLSEAEERERAFSGRGRWNQLRSMAEAKSLLQYIFNVAADARCQVREKEMEIKEMKEQMTELVTILRHSESRRRETEKQLKQREQAAVTATTSPGNGNGSVKHSADDSNTPLSPVAVPAQKQLKYSAGIVNSPSKGVPAFNKQHLKMVPMAQLPVGKKVSIAGQSGKLWRWKRSHHQWLLQFKWKWQKPWKLSEMIRHSDETMTRTRPRPQLLPHRPQRVM
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MFSCLCPAYAQGSLWKAIWKHLLLFIFLYYCINVVYRFFMTEEQQGIFLRYILIFDDFTKYIPLTFLLGFYVAMIVRRWWACCQLISWPDHLLFNISALIRGSDPETRIIRRTIARYAILTSVLAWRSISLRVLKRYPTDEHLVSSGLMTREELVIFKNIHVKVDPHQKWFVPVNWIQTMMVRCFEKGTLTHTNELRVLLDALEKFRNGFFQLFIYDWIAIPLVYTQVSTISVYGYFAFALIGRQYPSLNQFQQPVDIYFPVFTVLQFLFYVGWLKVGEDLMFPFGADDEDFEFNYILDRNLEVSFLIVDDLHNQVPPVYVESLKDEIELLHTKGSANLSNHPQRQHLRKYKMKDSEKKIYEHKNDHKVHPMTTSMRSDTHSACSFSDIEQAMLSPHNDHEGVRRFGRETEGALKAASAPAPPYLSFDTPGSQGRTALAAPGQDDGRPPRPSERQQRGLLTIDPPEIDFRPNSAPDPRLSTSLLCNPYPVKFLSKSLNSIEPR
The following text describes a protein:
Function:
Endoplasmic reticulum membrane-associated E3 ubiquitin ligase that plays a critical role in mitigating endoplasmic reticulum stress, the regulation of cholesterol and lipid homeostasis, and ferroptosis. Acts as a pivotal component of both the Ac/N-degron pathway (targeting the N-terminal acetyl group of substrates) and the ER-associated protein degradation-cytosol (ERAD-C) pathway (targeting misfolded substrates). For instance, mediates the degradation of Ac/N-degron-bearing proteins such as the G-protein regulator RGS2 and the lipid droplet protein PLIN2. Suppresses endoplasmic reticulum stress and ferroptosis through cytosolic POMC degradation (By similarity). Prevents ferroptosis by acting as a NADPH sensor during lipid peroxidation through its C-terminal regulatory region. Facilitates also the degradation of selected endoplasmic reticulum proteins by associating with signal peptide peptidase for the turnover of endogenous tail-anchored proteins. Promotes ubiquitination of DIO2, leading to its degradation. By ubiquitinating and thereby modulating the stability of many proteins of the cholesterol pathway including SQLE, CYP51A1, CYP11A1 and HMGCR, acts as a crucial post-translational regulator of cholesterol synthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Sequence:
MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
The following text describes a protein:
Function:
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.
Subcellular Localization:
Cytoplasm. Nucleus envelope.
Sequence:
MNTNAMDQYENCPSYGSFDVKSFSDSPIPFTNNNNNNNNNNNNNSICVMPSNYNNKNNNNNNNEKLEPEATLDVLTHALHTLYKSNDSNQRKLAEKWLILFQKQPIAWEFCPRLLLETNIFELQYFGASTLESKLKNEWNECNVEMKSKILNTIVSIIQNSTKLPICCVTRVSVTLTIAVMYTFPEIWRNAIFDIIHLSIKQDINTLSLHDPSQNHFNTDRLLMVLEFLSILPDELKKQDLALCKYSEIQKELKLIIDKIYKFLLSVLFLPINENFEFIKISYKALSAWLKYMLPSNGTMLQSCFEISFTVGQQKVSNNSNGNGNGNNNNNNNRNSIGYPLIDSLALVLEGSSLSIEGQSNGSCYIEAFRYAIEQSLTIFPTFYNEATVMNQDDSKAKPIFNVFVQFISSNNSQLFTTDLIHRCLNLLISFIEIGSRETISLLFYLIDDFKTHTMLVQQDQNILKFFFLKLLNRFLDVSMYPNGKDYCPIENGTNPLSTSQNAQFNGVLCETNIETLLDDDIEQFRSCSSDCLMNIQENDIIPKSTFLKFLIEKLNAFINEKCPHWEQYESILYYIYAFSGGSQDGQLEYVPILLNIIPLIPIKSIPLVRTSIKLIGRYSSFLKTNTDYLAKVVSDLLPALSHAELIGSAASSLLSICVSDKCSTMLWPHFNQILDQIEPILLGPQKSNPSIVLVYKSLLHILHKAPIHELSPLFTRLISPVIPNITDHIPRVKSKDHYNQLLVQLSILYSVNEIIEYDEFATMGANGEFTSPSKHPLYPFFQTTIPIQGQLLKHYKSEFEIIDCITTFYRYMMLYFREIANDFVDEILQQATQSFNQYPIASLLQIISSIIIPKLQPLTITNIKNSISLISNTFINTLKSVILATNNNNKNNDNTNNNDDNNNKNDNNNNNNNNDNDKSNFILDFTITPDITKDYLILITKILKTSPQCIEPNIISTICIYIIYNLTDLTKDKPTTGNCCLFLTNCLSLNNGKLQISDPNGNKVLEQIKNEMNALFESDPKHSYVLVYNILMNICWTPTSIQVTQHFSDVLLSFAIGYPNLLKLHATNILNDPNFIKDKQINPHDKQSFLTNILKSNSTQVDYRSSVRTFSFICNDKE
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKPPSPRSRQLRRMENFRKVRSEEAPVGNGEEGGGPGSGPFGDLAPGAVHMRVKEGSKIRNLLAFATASMAQPATRAIVFSGCGRATTKTVTCAEILKRRLVGLHQVTRLRYRSVREVWQSLPPEPTPDQKPDEPAASLTVLKNVPSLAILLSKDALDPRQPGYQPPSPHPGPSSQPTAPTSKRSLGEPAAGEGSAKRSQPEPGAAEEDQTA
The following text describes a protein:
Function:
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
Sequence:
MHCPFCDTEETKVIDSRLVSDGYQVRRRRECGHCHERFTTFEMAELIIPKIIKTDGTREPFNEDKLRSGIQHALEKRPVSADDVEKAINHIILQLRATGEREVPSKLVGKLAMNELKKLDKVAYIRFASVYLSFDDIDQFTIEIEKLKD
The following text describes a protein:
Function:
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity). Plays a role in the maintenance of heterochromatin (By similarity). Independently, MSI1 is involved in regulation of the RAS/cAMP pathway via sequestration of NPR1.
Miscellaneous:
MISCELLANEOUS: Present with 149 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNQCAKDITHEASSIPIDLQERYSHWKKNTKLLYDYLNTNSTKWPSLTCQFFPDLDTTSDEHRILLSSFTSSQKPEDETIYISKISTLGHIKWSSLNNFDMDEMEFKPENSTRFPSKHLVNDISIFFPNGECNRARYLPQNPDIIAGASSDGAIYIFDRTKHGSTRIRQSKISHPFETKLFGSHGVIQDVEAMDTSSADINEATSLAWNLQQEALLLSSHSNGQVQVWDIKQYSHENPIIDLPLVSINSDGTAVNDVTWMPTHDSLFAACTEGNAVSLLDLRTKKEKLQSNREKHDGGVNSCRFNYKNSLILASADSNGRLNLWDIRNMNKSPIATMEHGTSVSTLEWSPNFDTVLATAGQEDGLVKLWDTSCEETIFTHGGHMLGVNDISWDAHDPWLMCSVANDNSVHIWKPAGNLVGHS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAEWAPAQDLEWAMEPQELSLEQPLAAPEEGPGREAELPAAEISVTLVTEVQAVDRKVEAQAAQLMNLEGRMRMAESKLIGCERTAVEFGNQLESKWTALGTLIQEYGQLQKRLENMENLLKNRNFWILRLPPGAKGEVPKVPMAFNDTSFSFSEDEWKNLNEWQKELYRHIMKGNYEAVISMDTAISKPDLLSRIEQGEDPNAEDQDDSEGGETPTDPSTEFFFPGPDDNSWSKYEDTLAESHYGSEEEEEEEEESMEAPNTYAQQCDEECPDSLELPGSLAGKWDDVFSNPEEELKPSSKNRSGSGPQQRGAAGNGLRRSSRRGRELSKKEAPEEMAAEEGPYICCECGQSFLDKELFAAHQRAHMDEEACTSLEAGESFRQKSKSSAKGQRSRPSKRANSEKGSGYKYGFVRPNNMVERPYTCSQCKESFSLEVSLILHQKLHTGKGDGPLTCTYCGKDFRDLSKAIRHQRIHTGERPYQCTECGKSFIRRDHLLKHWRVHTGETPYQCPVCGKHFRYKESLNCHQKIHSRNPRPMDEALQHNLESATQTSLFCLKTETKQ
The following text describes a protein:
Function:
Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MNKWLCCALLVFLDIIEWTTQETFPPKYLHYDPETGRQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDYSYTDSWHTSDECVYCSPVCKELQTVKQECNRTHNRVCECEEGRYLELEFCLKHRSCPPGLGVLQAGTPERNTVCKRCPDGFFSGETSSKAPCRKHTNCSSLGLLLIQKGNATHDNVCSGNREATQNCGIDVTLCEEAFFRFAVPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESSVQRHIGHANLTTEQLRILMESLPGKKISPDEIERTRKTCKPSEQLLKLLSLWRIKNGDQDTLKGLMYALKHLKAYHFPKTVTHSLRKTIRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MALVPSSPRDNYIPLPDDKFPWKEPPAVVTTPCDPWPPPYYLEDGLRKVKPYHYTYNTYCKQRWRGREILDIFSSEFRDRPAEYYEKAIVEGRVVVNGQPVPSTKTTIKNGDIISHTLHRHEPPCTATPIGIVHEDDNLIVINKPAGMPVHPAGRYNFNSIIEILRADRGYGWNPLPCNRLDRLTSGIMFIGKHRQAAEDMSAQIRTRTVKKEYITRVAGEFPEGEVVCEKPILQISPKLGLNRVRANGKEALTVFKRLAYYPPKDDGKPGEEQDVEEGPDGQPWKKLRGYSIVRCFPVTGRTHQLRVHLQFLGHPISNDPIYANQRVFGPSLGRGHSETENDEDIMTRLARMGKEDIADAVAYHDEMVEAYNKRKAERMTGETCDICDTPLYSDPGTHELGIYLHARRYRCEEGKWDYETGLPDWALPPPGHQGPTESTEESDPLAIDLKKLGIDDEAGSGEAEKADKVVSKS
The following text describes a protein:
Function:
Receptor-like protein kinase required for cell elongation during vegetative growth, mostly in a brassinosteroid-(BR-) independent manner. Mediates the response of growing plant cells to the perturbation of cellulose synthesis and may act as a cell-wall-integrity sensor. Controls ectopic-lignin accumulation in cellulose-deficient mutant backgrounds.
Miscellaneous:
MISCELLANEOUS: Semidominant suppressor of the cellulose-deficient mutant procuste1-1; MISCELLANEOUS: This protein was called 'Theseus' after the Greek mythological figure Theseus, who slew the brigand Procustes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MVFTKSLLVLLWFLSCYTTTTSSALFNPPDNYLISCGSSQNITFQNRIFVPDSLHSSLVLKIGNSSVATSTTSNNSTNSIYQTARVFSSLASYRFKITSLGRHWIRLHFSPINNSTWNLTSASITVVTEDFVLLNNFSFNNFNGSYIFKEYTVNVTSEFLTLSFIPSNNSVVFVNAIEVVSVPDNLIPDQALALNPSTPFSGLSLLAFETVYRLNMGGPLLTSQNDTLGRQWDNDAEYLHVNSSVLVVTANPSSIKYSPSVTQETAPNMVYATADTMGDANVASPSFNVTWVLPVDPDFRYFVRVHFCDIVSQALNTLVFNLYVNDDLALGSLDLSTLTNGLKVPYFKDFISNGSVESSGVLTVSVGPDSQADITNATMNGLEVLKISNEAKSLSGVSSVKSLLPGGSGSKSKKKAVIIGSLVGAVTLILLIAVCCYCCLVASRKQRSTSPQEGGNGHPWLPLPLYGLSQTLTKSTASHKSATASCISLASTHLGRCFMFQEIMDATNKFDESSLLGVGGFGRVYKGTLEDGTKVAVKRGNPRSEQGMAEFRTEIEMLSKLRHRHLVSLIGYCDERSEMILVYEYMANGPLRSHLYGADLPPLSWKQRLEICIGAARGLHYLHTGASQSIIHRDVKTTNILLDENLVAKVADFGLSKTGPSLDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLMEVLCCRPALNPVLPREQVNIAEWAMAWQKKGLLDQIMDSNLTGKVNPASLKKFGETAEKCLAEYGVDRPSMGDVLWNLEYALQLEETSSALMEPDDNSTNHIPGIPMAPMEPFDNSMSIIDRGGVNSGTGTDDDAEDATTSAVFSQLVHPRGR
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MGMTSDSIANLLTRIRNALMAEHLYVDIEHSKMLEAIVRILKQHGFVAHFLVKEENRKRLMRVFLRYGEDRRPVIHALKRVSKPSRRVYVSAAKIPYVFGNMGIAVLSTPQGVLEGSVARAKNVGGELLCLVW
The following text describes a protein:
Function:
Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MCYYISILIYWGADCRTVGTGPVLMYCTKTIRSYFRCRHPFFSSINSSQIFFLSLLIAGECMFIPSAWPRVSTFHRLFIPALALLPYVFLYASVVTKSYITHENHEDEMARYPYDRVIFNPGHRCRTCDFLKPARSKHCSFCKACVSRHDHHCVWLTNCVGRNNYHYFLSLLLSLSLMLAYGSWLGFSLVSQTLEGLIPSSSPLRSKSQDWTTWLNVWAIAIASDIRVGAVAMLTAMTAPLAMAFLLYHTYLIWAGMTTNESAKWSDWKEDVADGLVFKSTRSEIYGNQSHSDEDTPAQRTWPVSSNQILVITDGEPPKEGFQLCSRSNEILQKDDPQAPVDTRWTEVNSMREIDNIYDLGFWDNLREVFHMPIRRCVR
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSNQSYLSICHQNKDGAVKNDTETSMPSAPIPINAGGREGNGKKKTRRAMPWMRFSRNGNTEVIECDTRTIMKRVSIPARDLRIRGPLFSSSSNILGREKSIIVNLENIKAIVTANEVLLLDPLRPQVLSLIDQLKKQFPQRNVPEDIQSSQEAEEGIQSELPFEFQVLESAFEVVCSFFDTRVTSLETEALPVLAELIEKVTRENLRIVRSLKSNLTCLIASVQKVKDEIEHLLDDDKDMAEFYLTRKVIQSQQEDVEDLEMLLEAYLIQVEGTRNKLHTMRKYIDDTEDYVKIKQKDKRNRLLVFKLVISRASFAISSGTLVVSLFGMNIPIPLYNTNGVFGYLVLGVFVMCIVLFMFTFGKAGWEKLL
The following text describes a protein:
Function:
Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.
Sequence:
MIFWCVVILPMVMGGLIANDSIENNLDIPFELTMTLVESRILEQLEKLSRTFGEEAKTINEKIDQLKRDTQSIQETNIMFNTTQQLMEKLSQQLQTASKSTEQRLTDLEHRLLDQLPEQSGVYFMQPDPAKNASFEVLRDWTNNHGFGGNWIVFQRRFNGSVNFYRNWTEYRQGFGELHGEHWLGLDKLHAIVSTRQHELLIVLEDFDGVVAYAHYDDFKIGNESEKYVIKSVGQYSGTAGDSFSPHKDEAFSTHDQDNDKHKTNCAEWVRGAWWFYKCHQSHLNGEYLRGKIDKQEGIMWLRFRGSYYSLKSTKMMVRPVA
The following text describes a protein:
Function:
Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.
Subcellular Localization:
Cell junction, tight junction. Membrane; Peripheral membrane protein.
Sequence:
MSKVIQKKNHWTSKVHECTVKRGPQGELGVTVLGGAENGEFPYVGAVAAAEASGLPGGGEGPRLGEGELLLEVQGIRVSGLPRYDVLGVIDSFKEAVTFKAVRQGGKLNKDLRHFLSQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALQSLHSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGDQEDHTLQETSLPPVNSSITAAPITDPSQKFPQYLPLTAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGIHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQPQQQQPQQQQQPEDWTEDHSSLVPPVIPNHPPSNPEPARDAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNGSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHGAQVLPEYPPAEAPASDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSAVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGAQETRNITKPKPESQFEFKPPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDGNGPPAGPQGVPEMRATPPDRRQHPSLESSYAPDLHKSSLHGEKRAQVRDPKGSRQPNEHHTWNGTSRKPDSGACRPKDWAPEGRRDAQPERMVTNGPKRRSPEKRREGTRSADNTLERREHQEKRREVSPERRRERSPTRRRDGSPSRRRRSLERLLDQRRSPERKRGSSPERRAKSTDRRRTRSPERRRERSLEKKSKEDKGSHRERERVEASLKQDAGRSSRHPPEQRRRPYKECSTDLSI
The following text describes a protein:
Function:
Endopeptidase with selective post-Arg cleavage site. Activates prophenoloxidase. Has a probable role in the melanization process as part of the innate immune response (Probable).
Domain:
The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Sequence:
MFLIWTFIVAVLAIQTKSVVAQSCRTPNGLNGNCVSVYECQALLAILNNQRRTQQDEKFLRDSQCGTKNSVPAVCCPCNAADGQQGNCVNINSCPYVLQLLKNPNEANLNYVRGSVCQGSEQQSICCVTAPQSTAVTTTPRPKRVHACQSEMTATPPNPEGKCCGRDIAVGDKIVGGAPASIDSYPWLVVIEYVRLERTMLLCGGALISGKYVLTAGHCVKGAILDVGTPKTVRLGEYNTTNPGRDCVSVSAGGTDCTDPLVKIGIEKTIPHPDYQPYHFLRKHDIGLIRLQSIAPFTDFIRPICLPSTDYTVNPPSKFALTVAGWGRYLQFDNGTVRSSKIKLHVTLPFVQRDVCEANQKPLRNGQRITLWKGQMCAGGEAGKDSCKGDSGGPLMYEHSKKYEAVGIVSFGPEKCGQIDIPGVYTNVYEYLPWIQNTIEP
The following text describes a protein:
Function:
Required for late and very late gene expression. Specifically required for expression from the vp39 and polh promoters (By similarity).
Sequence:
MERVWNPAAGIDGLKRSETYLVDPHDFVGVLTLSPYTVFERGLFVRMSGMRLLALLAAPKPQEPQPAVRRFPQRSRRNVCLKACADGAQSLAKVLAARVSMPPCMSKTMADLSSAPRGNMYRKRFEFNCYLANVITCTKCKTACLIGALLHFYRMDAKCVGEVTHLLIKAQDVYKPSNCAKMKKVTKLCPQASMCKGLNPICNF
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MCYFNYSKKDIRSLSFFYKICNIFGIVPPYSFEKPDSQKSLWKKIQGVVLVSIIAAGTAYSIYVRHTYYRRLYTITHLVLDYLDEFLIVALAFQVILNSCFCDPAKWIRLNNNLQYIDEVLKNRDSHETNLLRNVSVQFFVYVILYILATVFLAYVWICEMGVVTLQAYTLHLFCVLYVVLLHFLTYNLSLGIKLRYDDVNNLFRIEESEEKNIIVSLRQIGSLSQLLSETVALFNDVFGTCLILITGKSIVQLLTCLNFITNNLKSENEEFKEKLLAANLCLVIYTLVSVSLVMVTCDACTIASKQTISWCYKLQEQFVTNSEVRTELFKLAQHVSANIVHITAGNYFEINKATLCGIFGTTTTYFIVILQFNQSSAK
The following text describes a protein:
Function:
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
Subcellular Localization:
Nucleus.
Sequence:
MIIFATPKVCKGKTRILYFYLSKLFFYVYFFFLIYYSIQKHSYINSTMPIIPLEDDKDDDWILEDEDDPEFQAILQGNSSKGPAQRTLEGSVAAVSTRPQNDKYETIPVPVKINTPTHHAMDFENLKTYIYPTNFEIRDYQYNIVERAFYDNLLVALPTGLGKTFIASTVMLNFLRWFPISKIIFMAPTRPLVAQQIKACCSIAGIPSSKVAILLDKTRRNRAEIWNSRQVFFTTPQVVENDLASGVVNPKSIALLVIDEAHRAKGNYSYNNVVKFINRFSDSYRILALTATPASDVEGVQQIIDNLNISKVEVRTEQSIDIVRHMKRKTVERKTCYPSSEITECIELLAEGITPVLNTAKERGLLDLTDPTRINFLQCMEISRKIVANPTIPEGLKWSNYFILQLLGMVGQCYRRLNIYGIRSFQSYFNEKFLEFKTKWNAKKSTNKLNADFYFSDPITTLMDRVEELSKTLTYGHPKIEALMEELDDFFKNHETAGSRVIIFTEFRESALEIVQCIEKANDNRKPHIFIGQSKEKEKFDVENFGKKKQKGQTKKKKDERPSTRSSSENAQMTGMSQKLQKEIIKKFKKGVFNILVATSIGEEGLDIGEVDLIICYDSTSSPIKNIQRMGRTGRKRDGKVLMLFSSNEESKFDKAMGGYEYIQQHIMKGDFIQLRPQHRMIPDEYKPEAVKQLIQIPEENIELKAEDDEDEIIRIATSYMLGGKGKKGKKANNNSTKKPAKTFFMPDNVETGFKSAATMVRKVGDNKSLAERNKEKTFLDKLVDSDSESEVDKENENVIQEVDKSKNQEQNDHIITELDNTEQSVAGNTKSTTNGTSYSEPENNNQVNQESVTANLDSVARVPEPEVIENSESEEEQISKITHNTPATSVDLSNGPEETSYKIDSVLIDLIDDDFTFSSDTEGDKVEVIDAVSPEVCKLPEKPATPPIRKSLGVKRKVNKTPDPESNSISIPSSTTKKSHNEVTRKVVQDPSTTNKKSLGVKRPRPVSIIDQLKRQKIRSQVIVSRETQSIIEHESRTQSSLPSPRNMSDEISEIDVIIDLDDDDDDDNKVNGHDKSQTTISKVQPIYEFSNKEDEGFLSSSQTRELYKNYYIAIDSSDDIPFYDPVQGFSKIKDTDKFTMGRTGPITHSLRTQRLFQACNAEFDSQLAAQTKDNDKQDYTFILKK
The following text describes a protein:
Function:
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex.
Sequence:
MTNIRIKLLTVQVITSLASGENIDFEKVEKLVKDAGFVIGDIKALIAAIHFIIFNSVKNDVDESTLSTELQQLGLPKEHCDSISRAFREHKEKLRSIFHNNTLKLPSLHSLDWRVDFILSSNTIQEVNSPSVQLNFKVKNHSNNEITNHPFEISAKKFNVLYYELKGAKLLMETVNQ
The following text describes a protein:
Function:
Essential factor for meiotic homologous chromosome pairing (synapsis). Plays an essential role in promoting homologous chromosome synapsis. Does not seem to play a role in chromosomal axial element formation, sister chromatid cohesion at centromeres or kinetochore assembly in meiosis I.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Chromosome. Chromosome, centromere. Nucleus. Note=During interphase-early leptotene, distributed as numerous punctuate foci throughout the chromatin. Associates with chromosomal axes at leptotene and zygotene. Associates with chromosomal axes at zygotene. Removed from the axes of arm regions when homologous chromosomes have been synapsed. Localizes to centromeres until diakinesis.
Sequence:
MVMAQKTKEAEITEQDSLLLTRNLLRIAIYNISYIRGLFPEKYFNDKSVPALEMKIKKLMPMDTESRRLIDWMEKGVYDALQKKYLKTLLFCICEKEEGPMIEEYAFSFSYPNTSGDEVAMNLSRTGSKKNSATFKSNAAEVTPDQMRSSACKMIRTLVSLMRTLDQMPEERTILMKLLYYDDVTPEDYEPPFFKCCADNEAINIWNKNPLKMEVGNVNSKHLVLALKVKSVLDPCDDNNVNSEDDNMSLDNESDQDNDFSDTEVRPSEAERYIVAPNDGTCKGQNGTISEDDTQDPVHEEELTAQVREWICSRDTESLEVSDVLVNFPDISMEMVEDIMERLLKDGLLSRAKKDSYSVNKIADPTTPHIKKEVIMQNVSPTEGTKNSNGDLMYMKALYHALPMDYVSVGKLHGKLDGEASQNMVRKLIEKMVQDGYVKNSANRRLGKAVIHSEVTNRKLLEIKKILEVDIAEQMAIDTNAEPGEPERKDHLSGHEMRDGSTMGCLQSVGSDLTRTRELPEPQQNVSMQSGQEASTVDKDPSRTPTSVREQASVCSLESGVLGQKVRKSLAGAGGTQCSQDKRFRKASTVKEPILQYVKRQKSQVQVQVQ
The following text describes a protein:
Function:
NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MRYDAFISYSHAADGALAPAVQRGLQRLARRWHRPRALEVFRDQTGLAVSHALWSSIKVALDQSEFFVLLASPEAAASPWVNQEIEHWLSRHSVDRLLPVVTSGEWVWDADAGDVDLERSTAVPPALRGVFGEEPRHLDLRWARAEHELDLRHGRFRDAIAELAAGMHGMSKEDLDGEDVIRHRQMLRMRRGALAVVCALLLLVAGTAVAWRNARGEVTATNVALQRQRAATAAEQHRTEEAADQARSQQQIVEAEQQRAQKAAEEARGQQAVAEAEQQRALRAAGEARRQEGIAAAEQRRAQKAAAEARRQRGVADAEKAKANRAAAEAERQRKIAADEQRKAHEAAAEAERQREEAVKQQRIAIGRRLLGQAGEARDRDPRTAIQLGIAARHIYPGPQSQAGLVETLVRTHYAGTVTGHTAVVSAVALSGDGRTLVTDGLDGTVMVWDPTDRAAPRRLAQLTSSTAPVYTVALSGDGRTLVTGSEDGTAMVWDLTDRAAPRRLAQLTGHTDVVDAVALSGDGRTLATGSFDGTAMVWDVTDRAAPRRLAQLTDHTAPVTAVALSGDGRTLATGSDDHTAMVWDLTDRAAPRRLAQLTGHTAGVDAVALSGDGRTLATGSYDGTAMLWDLTDRAAPRRLAQLTGHTAQVYTVALSRDGRTLATGSEDHTAMVWDLTDRAAPRRLAQLTGHTDAVDAVALSGDGRTLATAASITRRCCGM