lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for proper chloroplast development. Involved in the regulation of plastid gene expression probably through regulation of plastid-encoded polymerase (PEP) dependent chloroplast transcription. Required for RNA editing of several chloroplastic transcripts, especially accD transcripts. Required for processing of the chloroplastic rpoA pre-mRNA (Ref.6, Ref.7). Required for the monocistronic rpoA transcript processing from the rpl23-rpl2-rps19-rpl22-rps3-rpl16-rpl14-rps8-rpl36-rps11-rpoA polycistron. Binds the intergenic sequence of rps11-rpoA for rpoA monocistronic RNA cleavage (Ref.7).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MFSLSLIQPRLRISEIPVTQSYKSPTICYSSDSRTKREEQRHVRLPGFRLVSGKRASFDSGFSGFKGENVNQDDSSSFDSERVDYALLAEWLQSSNGMRLIKRIHAMALKCFDDQVIYFGNNLISSCVRLGDLVYARKVFDSMPEKNTVTWTAMIDGYLKYGLEDEAFALFEDYVKHGIRFTNERMFVCLLNLCSRRAEFELGRQVHGNMVKVGVGNLIVESSLVYFYAQCGELTSALRAFDMMEEKDVISWTAVISACSRKGHGIKAIGMFIGMLNHWFLPNEFTVCSILKACSEEKALRFGRQVHSLVVKRMIKTDVFVGTSLMDMYAKCGEISDCRKVFDGMSNRNTVTWTSIIAAHAREGFGEEAISLFRIMKRRHLIANNLTVVSILRACGSVGALLLGKELHAQIIKNSIEKNVYIGSTLVWLYCKCGESRDAFNVLQQLPSRDVVSWTAMISGCSSLGHESEALDFLKEMIQEGVEPNPFTYSSALKACANSESLLIGRSIHSIAKKNHALSNVFVGSALIHMYAKCGFVSEAFRVFDSMPEKNLVSWKAMIMGYARNGFCREALKLMYRMEAEGFEVDDYIFATILSTCGDIELDEAVESSATCYLETS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements. Required for RNA silencing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSTMKFCRECNNILYPKEERDRRTLFFACRNCEHQEVSDNNCVYRNEVHHTAGERTQVLQDVASDPTLPRTKTVRCSACGHGEAVFFQATARGEEGMTLFFVCCSPDCGNRWRE
The following text describes a protein:
Function:
Non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). May also function in the peptidic vesicle transport pathway from the endoplasmic reticulum for the defecation behaviors.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MEKKVDENATLMNGVETTGPARDDVPETFREFLYNKKNGTVMGRTGKSWFQIIVFYIIFYAFLAAFWLTCLTIFMKTLDPKVPRFYGKGTIIGVNPGVGYQPWLKERPDSTLIKYNLRDQKSYKAYLEQMKTYLTKYDSNATETRECGAGDSNDDLEKNPDALPCRFDLSVFDKGCSEKSDFGYKSGKPCVIISLNRLIGWRPTDYQENSVPEEVKDRYKAGSIAINCRGATNVDQEHIGKVTYMPSNGIDGRYYPYVFTKGYQQPIAMVKFDTIPRNKLVIVECRAYALNIEHDISSRLGMVYFEVMVEDKPVEEKKEL
The following text describes a protein:
Function:
Presumably involved in the export of the biofilm adhesin polysaccharide poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA) across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKIRLELVYLRAIICAIIIITHLLTQITLKHENMEGGSLVLQFYIRNIVIFGTPCFIILSQLLTTLNYQKVTYRYLTTRVKYILIPYILMGLFYSYSESLLTDSSFNKQFIENVLLGQWYGYFIVVIMQFFILSYIIFKINYNLFNSKILLLLSFILQQSFLYYFTNNTAFHDTVLHYYPLSENTIIFGWIFYFFLGAYMGYNYERVLNFLERYLVIMIVLAVATYFVFIALANGDYWNVTSFSYSLTPYNSIMFIVILGICTHFKTMLFNTIQMISAFSFFIYLLHPIILDSLFAYTNIFEDNTMVFLAISLLFILGLCIGVGMILREFYIFRFIIGKQPYKLNINAY
The following text describes a protein:
Function:
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in the tip growth of root hair cells and in the elongation of trichome stalk and branches. Plays a major role in trafficking of Golgi stacks, mitochondria and peroxisomes during root hair development. Acts as the primary contributor to ER streaming with a major role in the movement of Golgi bodies. Required for development of pavement cells, trichomes, and stigmatic papillae. Together with XI-F, required for the regulation of organ bending, such as gravitropic root bending.
Subcellular Localization:
Cytoplasm. Note=Colocalizes with peroxisome, cytoplasmic vesicles, endomembrane vesicles, endoplasmic reticulum and/or organelles.
Domain:
IQ domain mediates interaction with calmodulin; The tail domain is a globular cargo-binding domain.
Sequence:
MVGPVNIIVGSHVWIEDPGAAWIDGEVVKINGEEVHAHTTNGKTVVANIANVFPKDTEAPPGGVDDMTKLSYLHEPGVLNNLAMRYELNEIYTYTGNILIAVNPFQRLPHLYDTHMMEQYKGAGFGELSPHVFAIAEVAYRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRSGVEGRTVEQQVLESNPVLEAFGNAKTLRNNNSSRFGKFVELQFDNCGRISGAAVRTYLLERSRVCQISDPERNYHCFYLLCAAPPEEREKFKLGDPKLFHYLNQSKCYKLDGVDDTEEYLATRRAMDIVGISEEEQDAIFRVVAAILHLGNVNFAKGKEIDSSVLKDEKSRYHLDVCAELLRCDAKKMEDALIKRVMVTPEEVITRTLDPDSATGSRDALAKTIYSRLFDWLVDKINNSIGQDPNSKTIIGVLDIYGFESFKINSFEQFCINFTNEKLQQHFNQHVFKMEQEDYTKEEINWSYIEFVDNKDVLELIEKKPGGVIALLDEACMFPKSTHETFAQKLYQTFKNYKRFTKPKLSRTSFAISHYAGEVTYQADLFLDKNKDYVVAEHQDLLIASSDTFVAGLFPRLPEETSSKTKFSSIGSRFKLQLQSLMETLSSTEPHYIRCVKPNNVLKPAIFENVNVIQQLRCGGVLEAIRISCAGYPTKRTFYEFLNRFGVLAPEVLEGNYDDKVACKMLLDKIGLKGYELGKTKVFLRAGQMAELDARRAEVLGNAARRIQRQSRTFIACKEFRALRGAAIVLQSNCRGKLACNLYEEMRRQAAAVKIQKIFRRHIARESYLRIRHSTITVQTALRGMVARNEFRFRKQMKAATIIQARLRSHLTHSYYKQLQKAALSTQCGWRSRVARKELRTLKMAARDTGALREAKDKLEKRVEELTWRLQLEKRQRTELEEAKTQEYAKQQEALETMRLQVEEANAAVIREREAARKAIEEAPPVIKETPVLVEDTEKINSLTSEVEALKASLQAERQAAENLRKAFSEAEARNSELATELENATRKADQLHESVQRLEEKLSNSESEIQVLRQQALAISPTSRTMATRSKTMLLPRTPENGNYLNGGTKTTPDMTLAVREPESEEKPQKHLNEKQQENQDLLVKCISQNLGYNGDKPVAACVIYKCLLHWRSFEVERTSVFDRIIQTIATAIEVPDNNEVLAYWLSNSATLLLLLQRTLKATGAASLTPQRRRTTSASLFGRMSQGLRGSPQSAGLSFLNRQGLTKLDDLRQVEAKYPALLFKQQLTAFLEKIYGMIRDNLKKEISPLLGLCIQAPRTSRASLVKGRAQANAVAQQALIAHWQSIRKSLNSYLNLMKANNAPPFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEYVKAGLAELEQWCIEATDEYAGSAWDELRHIRQAVGFLVIHQKPKKTLDEITRELCPVLSIQQLYRISTMYWDDKYGTHSVSSDVIANMRVMMTEDSNNAVSSSFLLDDDSSIPFTVEDISKSMQQVDVNDIEPPQLIRENSGFGFLLTRKEGSTS
The following text describes a protein:
Function:
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Miscellaneous:
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Subcellular Localization:
Nucleus matrix. Cytoplasm, perinuclear region. Nucleus, nucleolus. Cytoplasm.
Sequence:
MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSGSRISVSRSVWGGSVGSAGLAGMGGIQTEKETMQDLNDRLASYLDKVKSLETENRRLESKIREHLEKKGPQGVRDWGHYFKIIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVKYETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLEAQIASSGLTVEVDAPKSQDLSKIMADIRAQYEALAQKNREELDKYWSQQIEESTTVVTTKSAEIRDAETTLTELRRTLQTLEIDLDSMKNQNINLENSLGDVEARYKAQMEQLNGVLLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFSLNDALDSSNSMQTVQKTTTRKIVDGRVVSETNDTRVLRH
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MASGGAQMEVERRLRDVAARFVSLPESNKELQALLEEAEIWLSRVDQAPPESMRTALQPMMHALVRDDLLNHPDPGVKVGIACCLTEVTRVTAPDPPYEDNVMRGVFTVVVDAFGKLDDAQSPLFAKRVSMLETIAKVRSCVLMLDLECDDLIQETFTHFFRIVRPKLQESVVTSMETIMMFVIQESEPVHPGLASCLLRNLKKEKKDSLLASFELAERMVDLCPEKLKPAFAELLQGTPLNEYSNVVVKLIEGSSDAGRDDNIDAVENDMEPSKPEKDEQDGSPPYNTLNGSASSEQKSELPTDDKQTAVSDDKGAPETVTTEPEKLSGVNSKKSSKVGTSTESKVTEHSKVASDNQDVASGELSPETNGGNNKLTVEACNKVTDDTSNPLDSTPADGTSKPLDSIPAVDKPKRGRPPAVKSQEKKPVGKSQGSGLESKEIRSGSTSGGRPARGPAKDNKLSSRKSSEEESSKKPPTASSDLWKADTPSDEDTDEDLSLKEMASPKSLTKTGKSKGQPGYSGVSKRKLVQEAEEVPQSKKSKVLDGSLVGSRIKVWWPDDKKFYEGAVKSFDASSKKHKVVYDDGDVERLQLKNERWEFIDEEQDENPNEASDIGSRGRRGKQDSTGDSNPPKKRGRPKVVGEDSPVTSAKSEAKTAEKGAEGGGRWPRSAGKGSSKDESGGKTPKGASAVKASDGSKSNGLSGKRKPKEKVPESSADEEEEEEEPVSAKASTGKKRRRKALN
The following text describes a protein:
Function:
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention; MISCELLANEOUS: [Isoform 3]: May be due to exon skipping.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation.
Sequence:
MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINVEASKNKSKTSTKLHVGNISPTCTNKELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVRTPYTMSYGDSLYYNNAYGALDAYYKRCRAARSYEAVAAAAASVYNYAEQTLSQLPQVQNTAMASHLTSTSLDPYDRHLLPTSGAAATAAAAAAAAAAVTAASTSYYGRDRSPLRRATAPVPTVGEGYGYGHESELSQASAAARNSLYDMARYEREQYADRARYSAF
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKVHGSLARAGKVKSQTPKVEKQEKPKKPQGRAYMRLLYTRRFVNVTLTNGKRKMNPSPASQ
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDPEKRGYKFQEFVAHDADVRSLAIGKKTSRVFITGGNDRKVNLWAIGKQTPLLSLSGHTSSVEAVEFDTAEVLVLAGSSNGSIKLWDLEEAKVVRSLTGHRSSCTAVEFHPFGEFFASGSSDTDLKIWDIKKKGCLHTYKGHSGAIKTIRFTPDGRWIVTGGEDNIVKVWDLTAGKLLHDFKFHSGEIRCIDFHPQEFLLATGSADRTVKFWDLETFELIGSAGPESTGVRSTVFHPDGKTLFCGLDESLKVFSWEPIRCHDAVDMGWSNLADLSIYEGKLLGCSYHEHRVGVWVADISLIGPYALGVLPKANFFAELVSMDDNPVKSNDTTVKSIRTVATPHPKNSYKVQESGIAESGVRGSHLIPASTEKIKKDKSSTIPRRPDSFVKPSTPLRHVKLDSPSTNKKSAERNFRQRDMPLLSRTGISNTSSTTKRFHPTESVTVKDIYTTPQAVSVPVVVSRDILEDKTAGNVNRGIAGRATVIDDFHTPVHLRKPFPSGGAGDSVSSVRSVLTEPDVCSEGFSGLKFSFGLSQYGKKEGSDGTDKGDITQIAENMDRVVSLEHPVQSNDDKSAFEPPCSTTEPSRVKYVRGVAVPLGKTKSLVERFEKRESSSIDCSSPTGSCSDHIARADSPPTSLAGPIQGYEKDLSTVEEVMTPIDLVRNHEEFINVVKSRLTKLEMMRHVFNQNGIKGAITAVAKLPDIAVQADVVSTLKGKLGLFNLDIFSGFLPVLAGLLNSRTERHAIVSLELLLDLIKVFGPVIRSTLSASSTVRVDIQAEQRLQRCTRCFNHLQKILQALHPLIMRGGQSAQLAEELNMSLQDLVVF
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRYVQDLWSAFFPTEAVFPLQVVGRSGAAVESREELEKALTDTFLIFTYRDGFEAIPAVTRLIETDQGWGCLLRTSQMLLAHFLWVHGRPADRKLSLFFDHSAETAPFSIHNMIRSVWNRRVFKAEYWSPSQGCEAIKRTVQGAVKTEQLQTRVMVVTSTNGCIYADEVQHTFKQGADVVLVLASVRVSAAAQLTQESYLQIEKLMEQPQCLGVVGGVPGRSYYFFAHNQTQLFYLDPHQRTAAALLCEGLSAAASVTPSVADVRCVHWSRVDTSLFLAFAVTTRDEWAALEVHLSNRFMHVESQQTQRDCDHLGGARPGHADSTFVSPLQMGHSCAMGGASISETAPLVHRRTLRLPRKRFKEGGVGTATAAAAERDDGEDELDTDSWEYLD
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MADRLTQLQDAVNSVRNEFGFLGNVERNLNVLPIMTFKQILFKISAVLNSIPLSEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLRQLEEENHEAAARLEEVVYRGDMLLEKIQNALADIAQSQLRTRSGAPSQPVPDS
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MSDSEEEDGSGCEQAPEVPNEEVPRANSDIQLDSCLPTTDAMPNMTLISKEMDDKNSSRFKNLVPSKAMLQQVTTGEDSASKNFSIGKADMGEGHSEDIVQSPSIGLELSDFGFTVVSFLWNLMQDCEAEIADGMDHSDVPYVHQAFLADWRPDTSTLNHSEHISSASAEVNLGHDSISQDSQLYRGINNYGLSGNVQHQNGNQPAFPSIYKLPLPFHSTSDFRSGMKGAPSATIPKNPFLGTTSSSKYCSRPYRSRRPNSAHLVKLAPGLPPVNLPPSVRVVSQTAFKGFETGTSKVHPCRDGVNDVRKDNSASQIPHGEKIGIDHRAKRARPMPKDSGVHSQLESSETAEGRSTVAEKSTYADLQMHPLLFQVTEVGNTHYYPFKFKSDPSSSFSFFSGRQPQLNLSLFSSSQQQGHVDSANKSLQSKNSSLRLGGIDFHPLLQKSNNTQAPTSSDAIQAEPLVNSGVPDTTNISSGLYDKSNELDLEIHLSSVSESEKSMKSRQLKEHVPIESQQIIASSATEMNAPYCQQGGRIPSPSGCKLASSAPLVVPDDNITRYDDVGNQSHPEIVMEQEELRDSEEDIEEHVEFECEEMADSEGEDGSGCEQASEFECEEMSDSEEEDGSGCEQAPEVPNEEVPRANSDIQLDSCLPTTDAMPNMTLISKEMDDKNSSRFKNLVPSKAMLQQVTTGEDSASKNFSIGKADMGEGHSEDIVQSPSIGPRLVRRAQEAVVNGRSFSHTLVEVLYSINEQLQTDDIEAPLTKLRPVKKVALVVCTGDRGLCGGFNNAILKKAEKRIAELKGLGLDYTIISVGRKGNSYFLRRPYIPVDRFLEGGNLPTAKEAQTIADDVFSLFVSEEVDKVELLYTKFVSLVKSEPIIHTLLPLSPKGEICDINGNCVDAAEDELFRLTTKEGKLTVERDAVRSKTIDFSPILQFEQDPVQILDALLPLYLNSQILRALQESLASELAARMTAMSSACDNAIELKKNLSRVYNRQRQAKITGEILEIVAGADALV
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. During cytokinesis in male meiotic cells it is required for completion of cleavage furrow ingression, possibly in conjunction with Rint1. Required for maintenance of Golgi stack number and morphology, and acroblast assembly. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus, Golgi stack. Note=Dynamic pattern of localization during the cell cycle. Present in structures resembling Golgi stacks prior to their migration into the nuclear zone during prometaphase. At metaphase, detected at the kinetochores and kinetochore microtubules. During anaphase and telophase accumulates at the spindle envelope midzone and broad areas at the cell poles where they often become concentrated in small structures that resemble small Golgi-derived vesicles. In late telophase they also form compact aggregates at the interior of the equatorial region of the cell.
Sequence:
MEEEAPRFNVLEEAFNGNGNGCANVEATQSAILKVLTRVNRFQMRVRKHIEDNYTEFLPNNTSPDIFLEESGSLNREIHDMLENLGSEGLDALDEANVKMAGNGRQLREILLGLGVSEHVLRIDELFQCVEEAKATKDYLVLLDLVGRLRAFIYGDDSVDGDAQVATPEVRRIFKALECYETIKVKYHVQAYMLQQSLQERFDRLVQLQCKSFPTSRCVTLQVSRDQTQLQDIVQALFQEPYNPARLCEFLLDNCIEPVIMRPVMADYSEEADGGTYVRLSLSYATKEPSSAHVRPNYKQVLENLRLLLHTLAGINCSVSRDQHVFGIIGDHVKDKMLKLLVDECLIPAVPESTEEYQTSTLCEDVAQLEQLLVDSFIINPEQDRALGQFVEKYETYYRNRMYRRVLETAREIIQRDLQDMVLVAPNNHSAEVANDPFLFPRCMISKSAQDFVKLMDRILRQPTDKLGDQEADPIAGVISIMLHTYINEVPKVHRKLLESIPQQAVLFHNNCMFFTHWVAQHANKGIESLAALAKTLQATGQQHFRVQVDYQSSILMGIMQEFEFESTHTLGSGPLKLVRQCLRQLELLKNVWANVLPETVYNATFCELINTFVAELIRRVFTLRDISAQMACELSDLIDVVLQRAPTLFREPNEVVQVLSWLKLQQLKAMLNASLMEITELWGDGVGPLTASYKSDEIKHLIRALFQDTDWRAKAITQIV
The following text describes a protein:
Function:
First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
Subcellular Localization:
Nucleus.
Sequence:
MNVGSILNDDPPSSGNANGNDDNTKIIKSPTAYHKPSVHERHSITSMLNDTPSDSTPTKKPEPTISPEFRKPSISSLTSPSVAHKPPPLPPSSSSVGSSEHSSARSSPAITKRNSIANIIDAYEEPATKTEKKAELNSPKINQSTPVPKLEEHENDTNKVEKVVDSAPEPKPKKEPQPVFDDQDDDLTKIKKLKQSKKPRRYETPPIWAQRWVPPNRQKEETNVDDGNEAITRLSEKPVFDYTTTRSVDLECSITGMIPPSSITRKIAEWVYANFSNVEEKSKRNVELELKFGKIIDKRSGNRIDLNVVTECIFTDHSSVFFDMQVEEVAWKEITKFLDELEKSFQEGKKGRKFKTLESDNTDSFYQLGRKGEHPKRIRVTKDNLLSPPRLVAIQKERVADLYIHNPGSLFDLRLSMSLEIPVPQGNIESIITKNKPEMVREKKRISYTHPPTITKFDLTRVIGNKTEDKYEVELEAGVMEIFAAIDKIQKGVDNLRLEELIEVFLNNARTLNNRLNKIC
The following text describes a protein:
Function:
Acts as a non-essential component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC72 may be involved in signal peptide recognition for a defined subset of leader peptides, or may increase the efficiency of unusual or 'difficult' secretory precursors to the translocation pore, it may be that this protein binds charged leader peptides to the membrane until they engage the translocation apparatus.
Miscellaneous:
MISCELLANEOUS: Present with 5290 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MVTLEYNANSKLITASDAVVALSTETNIDQINVLTTSLIGETNPNFTPQPNEALSKMIKGLFESGMKNLQQKKLNEALKNVSLAIEMAQRKRAPWEAFAIQLPELHFMLRSKIDLCLILGKHLEALQDLDFLLGTGLIQPDVFVRKADCLLKLRQWEEARATCERGLALAPEDMKLRALLIETARNLAEYNGE
The following text describes a protein:
Function:
Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole.
Subcellular Localization:
Cytoplasm. Mitochondrion. Sarcoplasmic reticulum.
Sequence:
MEEPQTKTPSAEFPPYRAQPAQPATAPAATFATLAICPEPAPTSGPGQPCTAAMGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS
The following text describes a protein:
Function:
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
QEDQESLWVVSADNERYQCMLPKTLTSKTDADRSTPYTGPSPLMLLKPLFTRMFCSYKLEQYWTYELCHGRSIRQYHEENQPSKSRCIVQLAYCSLLSPSSEAEYLQQLKSRQEASNKKVRPPTMRLEGLEMPYFTVNMTDGTMCDINNVRRMTSVLYVCSEDSRNDILSLEEVSTCEYQVVVLTPYLCAHPDYRLDFAPENHISCIAKDGAPTRPKGMVLMDQEAHGLLYPEEQVGDVLTSTKRRQPPRESRPTVVDPVSVGGSSAPPHDPKLLQDFLSGEHCLTGGVGWWKYEFCYGKRVTQFHEANKPRTSILLGTWDKKSHVTWIEERSERKPKKGKIPKYVTHFYSGGDFCDATKKQRVVEVRLRCKDVKGHPDSVSLYLLEPRTCEYILGVESPIICNLLHNLDEHGLQQVTSDS
The following text describes a protein:
Function:
Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that has a crucial role in early T-cell development, particularly alpha-beta T cell differentiation.
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Cell membrane.
Sequence:
MAGTWLLLLLALGCPALPTGVGGTPFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASWEPLVCHTGPGAEGHSRSTQPMHLSGEASTARTCPQEPLRGTPGGALWLGVLRLLLFKLLLFDLLLTCSCLCDPAGPLPSPATTTRLRALGSHRLHPATETGGREATSSPRPQPRDRRWGDTPPGRKPGSPVWGEGSYLSSYPTCPAQAWCSRSALRAPSSSLGAFFAGDLPPPLQAGAA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLAIDVRNTHTVVGLLSGMKEHAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGFSVDHDVAIVATGHTAPLLLPELHTVDHYDQHLTLQGLRLVFERNLEVQRGRLKTAR
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
MFNKFTHHFRRDCHLCRRTRRLFSSKAGANNQWNSVVGLEVHAQINTTSKLFSGASTKFSAPVNANVALFDCAIPGTLPVLNKKCVEFGVLTALALNCRINPVSTFDRKHYFYADLPAGYQITQQRHPLANDGRLEFQVFSPGVHKAPYKRQVRIKQLQLEQDSGKSLHDTDRSLVDLNRAGVPLMEVVFEPDLSDGEEAAALVKELIAILQRLGTCSCKMEEGALRVDANVSINRQGEALGVRTEIKNIGSVRGVAGAIRYEIERQIQVKESGGAVENETRAWDALGKVTVSMRDKEQVQDYRYMPEPNLPPLHVAMGPVSQGCVSVDSLKSSLPELPEGTRVRLRESSGLTLEQSIILVNDSSLLNLFEDVWRAKKIEGKLLANLLINEYTSILNKMDLEPSQFSFNSDYFGEIAVLLQNGEITRNTVKLVLDEIIQGSTKRPLEIVREKNWLQITDEDALRQLCQEALDQNEKVVKQYKGGKTKVFKALLGYVATKSKQRADMKKCDKILKELLNKQ