lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MIAAHVPAASPGLSCCVALTPSLPPGFLQSPALKMHRVLFASLWLLAASPTSSIFQKPTGSPATPRLQYLLEPLHTAVHTQRGATATLPCVLRALPRNYRVKWSKVEPANYGESVIIITNGLYHKNYGPLSPRVRLRHSHRYDASLTITNVALEDEGRYRCQLVNGLEDESVSLTLHLEGVVFPYQPSNGRYRFNYHEAKRACEQQDARLATYQQLYKAWMEGLDWCNAGWVLDGTVHYPIINSREPCGGRLLLPGIRSYGAKDKQRDRFDAFCFTSALQGTSSIPQPCVVTLGLLTESSPSIISHLSLGEVYFIRGHLSFKEAGQACRNHGATIAKVGQLYSAWKFLGLDRCDGGWLADGSVRYPITTPRQRCGGLPEPGVHSFGFPRKELRTYGTYCFVGT
The following text describes a protein:
Function:
Transfers the 4'-phosphopantetheine moiety from coenzyme A to the 'Ser-36' of acyl-carrier-protein.
Subcellular Localization:
Cytoplasm.
Sequence:
MAILGLGTDIVEIARIEAVIARSGDRLARRVLSDNEWAIWKTHHQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPRLRLWGEALKLAEKLGVANMHVTLADERHYACATVIIES
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MATEPKEATEDAKIDLFEDDDEFEEFEINEEWEDKEEGKDVTQQWEDDWDDDDVNDDFSLQLRRELENNTEKKN
The following text describes a protein:
Function:
Activates gene expression by recruiting HAG1/GCN5 and triggering subsequent histone H3 acetylation of target genes promoters.
Subcellular Localization:
Nucleus.
Sequence:
MRLHSAITLRNLFTRKSLRIPQNLSITASPLLIGDVSGQIKPSSTSHYSKSSLSEASSSSSSSLIFQIPNNASFFLENQRRYSTGSSSGSPPDVNKVVDEINLKFAEAREEIEMAMDAKETVYFNEEAECARDAVAEVLEMFQGLLGKVTEKEKASLQRSMGLKIEQLKAELEQLNE
The following text describes a protein:
Function:
Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock. Acts as a mechanosensitive calcium channel in response to membrane stretch. The conductance is about 0.25 nanosiemens. Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Perinuclear endoplasmic reticulum.
Domain:
EF-hand domain is involved in the detection of calcium concentration.
Sequence:
MSSPTSPTSSPGRHHWSNSKDGMPPEYTNQDPNSDQADNENSDAKAHQPQHSPQHSTENQGHTGTSDTSSLEMELSKLHPESKQRQLPHSPEHERSRSPIASVVSYRSHMTLEDENQIFNAEMAVRGSQSLQRRPTGRSVRGSMRRLSSHRSKSMRTSKSKKSGDYERTAENEEAAQEAENHLDNFGVVTFGTEAPIKAPDHPVTIFGRIFKFIQQRSFYLRSLIYIIPLGVLLLIPVFIGRFYHPQPPYRDELGHEYERHLHVGGVDLMWMAIWWEIIWLSIWAARYAAKVIPYFFAFFVSFISNNVTKWRCMAVALEFPITLFLWMLAVYVSFLPIMTRRHIGDYGVPDHVRVKLPWQQSANNVLITLFITSIMNLVEKVLMQLIAMSLHRREYESRILYNKFAINELARLYGYARQRSFDFKDAIHRAQADVFKFADHQHGKKRAAAARVAQNALNKTTYKAISAFNFATDMVNKVAGEITNREVEKSSSPKSVVLHLLKTTRGCQSLARCLFEALVNPENPDLVLDDFIPVYTDETGEVDNATLEACYSIFDRDLNGDITCEEIELACVEIGKERKSISASLRDLNDSISKLDGICMFIVAVITLFIFLYLIARNFSGVLTSAGTTLLGLSWLFSGSAQELLSSIIFVFVKHPYDVGDRVDVMINGTVTSAMVKEISIMSTEFRLLTGKVIQAPNSLLNTLWILNMRRSDGIADPVTVNLKFGTTLQQIEQLRIKIIDFLKEEKRDYKPDLLTEVTDLPDLYSMSLCVVFFHKYNFQDEVLRMRRRNMFMCALMTYMQELDIVSPIFNSPGKSKDSPMYVNFNNGSMEGVKLSGGNDGGGTENHRDSTVGGGILKNPKAYPYREPTPPGSSDSDTASVSKKRVDFSLGTRHLMPAFDDVADIGSKRLGRDSLPDAVIENAGTEAMRREAEERRRAEEEEYERSQQESSSNEENENASRTSGARFSFSSKASRLSARPSARTVPPLQHISIQDLREPNENNTSKSARL
The following text describes a protein:
Function:
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of mat-Mc at mat3-M.
Miscellaneous:
MISCELLANEOUS: There are three genetic loci for mating type genes in S.pombe, mat1, mat2-P and mat3-M. Cell type is determined by the alternate allele present in mat1, either P (plus) in a h+ or M (minus) in a h- cell. Mat2-P and mat3-M serve as donor of information that is transposed to mat1 during a switch of mating type.
Sequence:
MDSHQELSAGSPISYDFLDPDWCFKRYLTKDALHSIETGKGAAYFVPDGFTPILIPNSQSYLLDGNSAQLPRPQPISFTLDQCKVPGYILKSLRKDTTSTERTPRPPNAFILYRKEKHATLLKSNPSINNSQVSKLVGEMWRNESKEVRMRYFKMSEFYKAQHQKMYPGYKYQPRKNKVKR
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MSSQNTPSATSPTIEPQNTNNNNNESQTTQVAAPANTCVPNCNSCTSPSVTNSIEIEQLIANNHAWSTRIKQEDPGFFAHLAQAQKPRFLWIGCSDSRVPAERLTGLESGQIFVHRNVANLVIHTDLNCLSVLQYAVEVLQVEHIIVCGHYGCGGVAASYDNPELGLINNWLLHIRDLTFKHAELIEMTKSNRKRLLSTLCELNVVEQCNNLGNTTIMQSAWKKGQNVKIHGWIYGIHDGYLRDLGVSASSRETLELNYKNAILKLKDNCSLGDSN
The following text describes a protein:
Function:
Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein.
Sequence:
IASVYNMEKEMPGQPLEGGWGWVVVLSGAIVYGLVFGSVRCQSVLFVPIMNEFESDYSNVGWVSAILTAGLAIGGMISASVMAKFGHRSAVIIGGLISGASSIIASFSTSVVMLVIFAGLLQGIGYGISFVATPVIIGYYFAKRRSLATNFASMGGSLGTFLICPLNGLFVEQFGIHGYFLIMGGLYFNLCVVGSLMRPLELSRSLAKPKEPKPATEMRVIEELSPGRDTDDIETEDNTEISEEKIQIEREISLGNLLKKKPFLVYCISQLVFLAGFLTSQLYIVPYAEIEVQIPSVKASLLMSIAAAAEIASRVVFGILGDMKRVRKILNTIFVFILYYVYSSINRVLMYSTVLLVLSVCGISYTFMKSFESLAVAADLVGLQYYGMALGLSTVINGIGTLITPPLVG
The following text describes a protein:
Function:
Acts as a negative regulator of hedgehog signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MALGRALAAVLALCLAMLGPMSPGARAGDCKGQRQVLREAPGFVTDGAGNYSVNGNCEWLIEAPSPQHRILLDFLFLDTECTYDYLFVYDGDSPRGPLLASLSGSTRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGGCRNHGQCRSPGVCACEPGWGGPDCGLQECSAYCGSHGTCASPLGPCRCEPGFLGRACDLHLWENQGAGWWHNVSAGDPAFPARVGAAGAFLSPPGLLAVFGGQDLNSALGDLVLYNFSANTWERWDLSPAPAARHSHVAVAWAGSLVLMGGELADGSLTSDVWAFSPLGGGHWEQLAPPASSSSGPPGLAGHAAALVDNIWLYVSGGRTQHDLFSSGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFYAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRRVWTTLKGRDGLQGPRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDLMAYKVPPFVFQAPAPDYHLDYCSMYTDHSVCSRDPECSWCQGSCQAALPPGTPSGACLAASCLGLGRLLGDCQACLAFSSPAAPPRGPGALGWCVHNESCLPRPEQAHCRGEQISGTVGWWGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNASQPDKVLIVRSTTITLTPSPETDVSLVYRGFIHPLLPGGPGGPGAEDVAVWTRAQRLHVLARMARGPDPENMEEVGRWVAQQEKETRRLQRPGSARLFPLPGRAHKYAVEIRGQLNGSAGPGHSELTLLWDRTGVPGGSEISFFFLEPYRSMACASYSSCLGCLADQGCGWCLASSTCHLRQSGAHCMDSGARRSLLVLVPALCPLCEEHRDCHACTQDPFCEWHQSTNRKGDAACSRRGRGQGALKSPEECPPLCSQRLTCDDCLANSSQCAWCQSTHTCFLFAAYLARYPYGGCRGWDDSVHSEPRCRSCDRFLTCHECLQSHECGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGLGLSVALPARWAYARCPDVDECRLGLARCHLRATCLNTPLSYECHCQRGYQGDGITYCNRTCLEDCGHGVCSGPPDFTCVCDLGWISDLPPPTPAPGPPGPRCSRDCGCNFHSHCRKRGPGFCDECQDWTWGEHCERCRPGSFGNATGSGGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHTEGAHCQLCIPGYYGDPRAGGSCFRECGGRALLTNVSSVALGSRRVGGLLPPGGGAVRAGPGLSYCVWVVSATEVLQPCAPGTLCPPLTLTFSPDSSTPCTLSYVLAFDGFPRFLDTGVVQSDRSLIAAFCGQRRDRPLTVQALSGLLVLHWEANGSSSWGFNASVGSARCGSGGPGSCPVPQECVPQDGAAGAGLCRCPQGWAGPHCRMALCPENCNAHSGAGTCNQSLGVCICAEGFGGPDCATKLDGGQLVWETLMDSRLSADTASRFLHRLGHTMVEGPDATLWMFGGLGLPQGLLGNLYRYSVSEWRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLMGGLTAGGVARDFWILNLTTLQWRQEKAPQTVELPAVAGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYAHSAVYHEATDSLYVFGGFRFHVELAAPSSELYSLHCPDRTWSLLAPSQGAKKRGVWENLQGLLVQGPGPQVTELTEHRVWECRNRRWLWGPLRKEGGFLEEGDLRPPVSQQPRPRLFHASALLGDTMVVLGGRSDPDEFSSDVLLYQVNCNSWLLPDLTRQASVGPPMEESVAHAVAAVGGRLYISGGFGGVALGRLLALTMPPDPCRLLPSPEACNQSGACTWCHGVCLSGDQAHRLGCGAPACSPMPHSPEECRRLRTCSECLARHPRTLQPGDGEASVPRCKWCTNCPEGACIGRNGSCTSENDCRINQREVFWAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHSLLNVSPMPVESSPPLPCPTPCHLLPNCTSCLDSKGADGGWQHCAWSSSLQQCLSPSYLPLRCMAGGCGRLLRGPESCSLGCAQATQCALCLRRPHCGWCAWGGQDGGGRCLEGGLSGPRDGLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKTGYLMDNVTGLCRPVCAQGCVNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECTGVGARDHCLLCHNHTKGSHCEQCLPLFVGSAVGGGTCRPCHTFCRGNSHVCISRKELEMARREPEKYSLDPEEIENWVTEGPSEDEAVCVNCQNNSYGDKCESCIHGYFLLDGKCTKCQCNGHADTCNEQDGTGCPCQNNTETGTCQGSSPSDRRDCYKYQCAKCRESFHGSPLGGQQCYRLISVEQECCLDPTSQTNCFHEPKRRALGPGRTVLFGVQPKFTNVDIRLTLDVTFGAVDLYVSTSYDTFVVRVAPDTGVHTVHIQPPPPPPPPPPPAEGGPRGAGDLGGPGTGSGSGTPMEPPLWEVWPRGLITYVTVTEPSAVLVVHSVRDRLVITYPHEHHALKSSRFYLLLLGVGDPGGPGANGSADSQGLLFFRQDQAHIDLFVFFSVFFSCFFLFLSLCVLLWKAKQALDQRQEQRRHLQEMTKMASRPFAKVTVCFPPDPAAPVPAWKPAGLPPPTFRRSEPFLAPLLLTGAGGPWGPVGGGCCPPAIPTTTAGLRAGPITLEPTEDGMAGVATLLLQLPGGPHAPNGACLGSALVTLRHRLHEYCGGGGGAGGSGHGAGVGRKGLLSQDNLTSMSL
The following text describes a protein:
Function:
Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVMLHWYKILLGISGTVNGILALTLISLTLLVSQGVLLKCQKGSCSNATQYEDTGDLKVNNGTRRNISNKDLCASRSADQTVLCQSEWLKYQGKCYWFSNEMKSWSDSYVYCLERKSHLLIIHDQLEMAFIQKNLRQLNYVWIGLNFTSLKMTWTWVDGSPIDSKIFFIKGPAKENSCAAIKESKIYSETCSSVFKWICQY
The following text describes a protein:
Function:
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. The relevance of N-epsilon-acetyltransferase activity is however unclear. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes to the cytoplasm in interphase cells.
Sequence:
MKGSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEKDGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKNLKISSPGQNADVQKSEN
The following text describes a protein:
Function:
Transcriptional repressor that negatively regulates G1-specific, SBF- and MBF-dependent transcription. Binds via SBF to promoters of G1-specific genes to repress transcription in early G1. During G1, phosphorylated by cyclin-CDK CLN3-CDC28 and progressively hyperphosphorylated by CDK associated with other G1-cyclins, which leads to dissociation of WHI5 from SBF, activating SBF-dependent transcription in late G1. Elimination of CDK activity at the end of mitosis by the mitotic exit network (MEN) allows WHI5 to reassociate with SBF to again repress G1/S transcription.
Miscellaneous:
MISCELLANEOUS: Present with 1440 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles in a cell cycle-regulated manner. Localizes to the nucleus, where it is associated with SBF-dependent promoters. In late G1 phase, phosphorylation by G1-specific cyclin-CDK causes its export to the cytoplasm. Elimination of CDK activity at the end of mitosis allows WHI5 to reenter the nucleus.
Sequence:
MSLRTPKRSRTSDEQEQEQEQEQVQNPDTHVNNEHQQRPGPTTLLSTPVRLKNGFGTPSPPSPPGITKSITKSRRRPSTTSLQGIFMSPVNKRRVGITAHGRVYDHNDDGHESESEDDENEEENENQKKYDGHVSMPLLPPTTPKSRRSEVFLSPSPRLRSPPTAARRSTGERPIREISHTLRTRLNYALVKLQNGWTDKTLPELETELAPAVQTPPRRYHNRFPDSADAGTSAHTAFLQALGGHPPREEATAVETLMLLSSPTKKQQHRPVPATSAGEPTDETEPESDTEVETS
The following text describes a protein:
Function:
Involved in 20S proteasome assembly.
Sequence:
MKSSSGTSLRKVFNPDLKHSTLIIPSVSIGNVPQLAIDLLIHTHNLEKVDSLDDLYLYPFASPVDYVTEPKKGISHAAEVFHNKDLNLTLIQQRSPILPYNTKLYVTNIIIPFITSHEFDRILILDSSDAGLVEHISSGGIELYTKEDLLSESLESMKLSKEESTTAAHEDNRNSKYVRCLLENFNLSNDSNESHSNEFKDVVIDLLVSYVYEGDNFYDGENLANKVNSVLSLPAVQKWVRPVSWAGVYGDKPVPNAMEQGLYG
The following text describes a protein:
Function:
Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A. Target proteins are preferentially recognized via a LXXLAP motif (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity). Also hydroxylates HIF2A (By similarity). Has a preference for the CODD site for both HIF1A and HIF2A (By similarity). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (By similarity). Also regulates susceptibility to normoxic oxidative neuronal death (By similarity). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (By similarity). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (By similarity). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The beta(2)beta(3) 'finger-like' loop domain is important for substrate (HIFs' CODD/NODD) selectivity.
Sequence:
MDSPCQPQALNQALPQLPGSVSESLEPSRARMGVESYLPCPLLPSYHRSGASGEASAGNGTPRTTATATTTTASPLREGFGGQDGGELWPLQSEGAAALVTKECQRLAAQGARPEAPKRKWAKDGGDAPSPSKRPWARQENQEAKGESGVGCDSGGGSSNSTTHSSGEASSRLREEAQPSAPERLALDYIVPCMRYYGICVKDNFLGAVLGGRVLAEVEALKWGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGNYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAARDKYQLASGQKGVQVPVSQPATPT
The following text describes a protein:
Function:
Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to agmatine to yield N1-aminopropylagmatine. An efficient aminopropyltransferase activity has been also observed with norspermidine which produces thermine, and spermidine which produces spermine and thermospermine. The aminopropyl activity with homospermidine, mitsubishine, thermine, 1,3-diaminopropane, putrescine (1,4-diaminobutane), spermine and caldopentamine are very low. The reaction involves a nucleophilic attack on the C-3 methylene of the propylamine moiety adjacent to the positively charged sulfur of decarboxy-AdoMet.
Miscellaneous:
MISCELLANEOUS: In T.thermophilus, the biosynthetic pathways of spermidine operates via N1-aminopropylagmatine without the production of putrescine.
Subcellular Localization:
Cytoplasm.
Sequence:
MDYGMYFFEHVTPYETLVRRMERVIASGKTPFQDYFLFESKGFGKVLILDKDVQSTERDEYIYHETLVHPAMLTHPEPKRVLIVGGGEGATLREVLKHPTVEKAVMVDIDGELVEVAKRHMPEWHQGAFDDPRAVLVIDDARAYLERTEERYDVVIIDLTDPVGEDNPARLLYTVEFYRLVKAHLNPGGVMGMQAGMILLTHHRVHPVVHRTVREAFRYVRSYKNHIPGFFLNFGFLLASDAFDPAAFSEGVIEARIRERNLALRHLTAPYLEAMFVLPKDLLEALEKETMVSTDQNPFYVTPEGEARQAPYKG
The following text describes a protein:
Function:
Transcription factor that may act a transcriptional activator of nuclear-encoded photosynthetic gene expression (Probable). Binds DNA via its zinc fingers. Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promote its expression when in complex with RGA.
Subcellular Localization:
[Isoform 1]: Plastid, chloroplast; [Isoform 2]: Nucleus.
Sequence:
MSSSSYNTSVIPSSSSSAQPFFITSSGTGDNDFNRKDTFMSMIQQPNSSAPPPKKRRNQPGNPNPDAEVVALSPKTLMATNRFICDVCNKGFQREQNLQLHRRGHNLPWKLKQKSTKEVKRKVYLCPEPTCVHHDPSRALGDLTGIKKHYYRKHGEKKWKCEKCSKRYAVQSDWKAHSKTCGTKEYRCDCGTIFSRRDSYITHRAFCDALIQETARNPTVSFTSMTAASSGVGSGGIYGRLGGGSALSHHHLSDHPNFGFNPLVGYNLNIASSDNRRDFIPQSSNPNFLIQSASSQGMLNTTPNNNNQSFMNQHGLIQFDPVDNINLKSSGTNNSFFNLGFFQENTKNSETSLPSLYSTDVLVHHREENLNAGSNVSATALLQKATQMGSVTSNDPSALFRGLASSSNSSSVIANHFGGGRIMENDNNGNLQGLMNSLAAVNGGGGSGGSIFDVQFGDNGNMSGSDKLTLDFLGVGGMVRNVNRGGGGGGRGSARGGVSLDGEAKFPEQNYPFGRG
The following text describes a protein:
Function:
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
RGGRRRRGTSDYVYFQVPNRSVRISENLPAGSPVTTMRAYARNEVATQNVVYRLEPRQNRHSLELFRIDPHTGVITTNSSLDREDMSIHFFNVFAVRPDINQARGTLKVYVIDVNDNSPIFERPSGYNVAIRENQAIRTQIQTVKADDADSGKNGELTYSIVRSVPHTNAFAITQEGNLIVNGLIDREAHSQYLLTIAARDQGSPSRNSTVPVTVTIEDVNDNHPQFTRAQYNVRVYENARVNSIIANISATDADSGMNGLVSYVLYSGRRTFRINPQTGEISLIARLDYEVTKRYQLRVRATDNGRPALSNTSGLVNVQVLDINDNTPHFISSPYNKVVLESAPVGSKILQVEAEDGDALRSSSRIAYTILNRGSPVPFRIDLQNGTIQLSQKLDHERQGSYTFTVQASDHGSPRRTATTQVTINVRDVNDNAPYFTSNSYQKRVAEDMALKSPIINIEARDPDTDATISISYRIIAGNQDRKFSIISRNGIGKISLAKALDYNEQRHYRLTVEASDGSLKNTTFVYINVTDTNSHTPIFEPNYYPVTLPENVPIGHLVVQVHAVDGDIGDNARITYCFSDAVSNFQINSNNGEIRTRQKLDFDNLSKIMLGVIARDNGIPPEEDRAVVEISLTDINDNAPVFQQTKYQGEVSEDSRVSQRVLTIHATDRDSSNNGEIRYTFEGGNNGNGYFSVDPHSGDIRTALPLDREHIDKYDLVAFAVDQGTPKLSSSVAITINILDVDDNPPTFKNDTLYFKVKEDVDIGHVVARIKATDPDQTTSDIIYDIGHDPEVLRYWKLNPDTGELATVDVLDYERKRNYTFIVSALSNELVSQATVHILVQDCNDNNPVLSDFEIVFNNYRTRLSDSFPVGVIGEVPAYDPDVSDTLTYRFLSGNDGKLLLLQHNTGEIGLNKTALDSNRQFSTRMRIEVSDGLHRTPAWCTLRVTGITDEMLSHSITVRVLHMNAYSFLSPLMYSFIDGLANILNTTSKNVFVFNVQNDTDVKHEILNVSFSAKKERGEFFTSKYLQDQVYLNRQRLSELTTRNVLPFDDNICLREPCQNYKRCSSVLTFDSTAPFVSSRLMIFRPIYPVYKLKCECPIGFTNDIKCADEINMCYSSPCVNNGKCLSREGGFTCICREGFAAENPGERCEINMKQGRCIDYIGVCRNGGQCVDGPGSDEFHCVCAHPNHSTATCELRSREFNHGSFLMMQGITNQWHFTLSISFSTTQENGLLFYNGRLNHEHDFIVLELVNGQVQLNFSTGQNWDVVQPFVDGGLNDGTWHTAKVEYYNERKPGPLPTGIRSRYGPSHNKVAILTIDPDICDPMVAQQWNETYGTYSCSKQVKQMGQKSSLDLTSPLFIGGVPDLPEDFQVRSKSFTGCIRDLYLDGKILDLDKFITKNGSLIGCPSTETKCRPNSCYNGGTCTSTWEDTHCDCKDEFTGKKCQHQSELFMQLLGVGCVEFTQKNRLLPFKLPWRVQVDFRTRDLNAIILHVATAGIQMDLKIENGYLWYVVQSHVPIRLGISNAPINDGEWHHVTADWIDSGSQRVFVKLNLDYNAHQANVTSSSASLRQMSISRVMIGGKYLSGRTISPYKGCVKGLKLGPPNTMYPISDSSLRPHGGATHRQGCRVTDACRTHSCPRNSVCVSTWGDYECRCNTGYIGQHCTSVCSLNLCQNGGICRNNISATYGYSCVCPPGFRGPSCTDRYTTECPKGWYGTEGTCAPCKCSIQDNFDEACDKISGECICMSNHYFVSATGKCEPCGCYRPGSVGLSCTEDTGKCHCVSGVSGRQCNLCISHLAEITNDGCEVLYAGKCPRSFIGDVLWPRTDFGKQSPVKCPPGSKGIAYRMCDTVQGWLKPDFSGCVSDAYYSFGVIVEDLENNVTEMSSPKAIELASELSVATKSTNKLYKKDAINSFQIVQELLTHQSKQKDFGLAVAADSAFTDHVAEASSALLSNNSLHFWSSNSDEKHDSANPLSAPVFIKAWEGYTSTLLQNLHKIFYDSTVVTTDNINMSLYSVDRDISLFGEYIQVLRFFISFSLKLVLKHTIIFSHTSFYPGYSYPLIEGRAENEVSVKLPKYLFSTVNPFNITSQKVKTWNSTYLVLAVGVVTYNNLNKILPHTFEDDRTFRIPKKPSINSMIVSIQVYSSKLDHKPDDGMVTKLLEPVKIGFKLINAEAIEPQCVFWNFTTKSSPSSTGGWSQRGCTRSFSNKTHVTCDCYHLTTFAVVTDEDVSSVTNQLEVRIPMIIGVVVSMVFLLISFLCSLLLPGVKSIRALINRNITGALFLTNLIYLVGVQQTSNLYWCMAVAILLQFLLISAFSWIFVDGVHLYRVLTERRDINHGQARIYYLIGWVLPAIITALSIGLDAKSYGNVNFCWISFDDVLIWSLAAQGPVLLCCVIFLILLCLSVNAFLTSKRTDMKREEILHDLRASFFVTPVIMGTWCLAIFAVNLNLTLHFYLFSLAVALEGGMIFFFHCFTNKEVRLAMTKYRENCSRKVDHNSTTQRLLQSHSPVTFDVEVSDSEASDSYGDTSSDSSISLDSSTDDETTQ
The following text describes a protein:
Function:
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46. Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPAPNGGEAPPPESAQAPKGTFPPFPPPPRPSVTSQAARACAWGRARGRGRFPGPRGAAAPLPQGTLRRRPRRPLMEPPGLFPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSSGISSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPLLDSIQIQPSGGTTFGRHNGQS
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRRETVFAIALLAAVLSPSSQGDMWSFKWTPELIDWRAIRDNVHQEEKHHNVGEFETLCRIYRITQAEAPQPSFKNREKEGEILKKLEEMVSEAETVAGNKGSSNSSNSTTAYQEMKKLFEKAKKLKEEIEVNRTRSLNASRSAEENMLRAVYGDAVDVARNENKTLEEAMRGNKSLLFNSVYNAATSCGSFGDKLVGKTLINDFFCLCVGEAIDIVKKEERGTHHHDSDVEDSSDDNIYNGYNCPCKDEIRRPENGSWTMMADSCKGDNSKCDPKKIKYNHTEAWDVISKACAYKNVASNVKTLKSALAQFDALVNLGQNGHQVKGILGYVRTDHNENSTCLGYTAGFTCVSYNHTLENGGIPWYNHLTNATEQLQEMAKYAKESDSHLHELEEYQHEAEEIFLEVKLGGDAGLWKSNRAQGESDSEGYDTGVNNDCFYYIDVKTGVVMLLILSLFCMF
The following text describes a protein:
Function:
Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits.
Subcellular Localization:
Secreted. Cell projection, cilium, flagellum. Note=Specifically localizes to the segmented columns and the capitulum of the sperm connecting piece.
Sequence:
MPKVKALQCALALEIRSVTCPGVVLKDKEDIYLSICVFGQYKKTQCVPANFPLVFNARMVFEKVFPEAVDPGDVVAQLEYDTALFELIQLVPPVGETLSTYDENTRDFMFPGPNQISGHHDSNRQVTMRRISGLRGIAPKLEFSTTSVITECLISSRKCRTQDKFVYHTAPVEKPHSRLQNRTSRSQKKKSKSPERNKYCINAKNYEQPTTSKSHSPSPYTKRRMCELSEDTRRRLAHLNLGPYEFKKETDKPPFVIRHVDPPSPRADALFGSPGRDCERDGWSRLHNDHSHLGCYRPKDYKVIRTPHGRDFDESLERCEDYLSSRSCSKPQHSARTLLVHSAPSTMPKHSPSPVLNRASLRERFHSDWCSPSNCDEIHDRVKNVLKSHQAHQRHLYDERDPEKEDELELKRGLLYRDSAYDSDPEYSSFQRPRGTLHLDDGEYWSNRAASYKGKSHRPIFENSMDKIYRNLYKKACSSVSHTQESF
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Sequence:
MKSAFNKLRPNFWSRLTPSSDGDYFFVELEDAHRTWHPGDTVHGNVILVLYKPQRISSVDLSFAGNVVVKSALVKGKGSRSVLFEQKLRLHGTPTAGSNSNTTPSSGNHNSHVSNSATNSNRNSGSHMSTRTSNRNSNSHVASNTPSMSTSPTSTSSGVAATADTTTTMDTNTSQASSTAPDTLNPSSSTELSRTATRQSSDGSIWRSVGSSTPGAASGGVADMMMNSVTTEPVLSSRMSMHTTNSHLSQMSRESHVTTASRESHMSRESNTSTSSTSEELEIGEHRFAFILEIPQKGLFNSLEFERGSISYVITAVAKRHGPLPALHAKRVLQLVCPVDVARLPPPKPSTLSVEIQKRKKQQGIITTTLEVGRGGYLRGESFPVKITIQHVKCVKCLRGLVVTLCRFSKVTCNDDEPQSFRKDLSQTVSPLYTDPVTFSSTVSTTLRIPPDVFPTTKGHGLVSFNYCVEVVIDLAGKWDLEEDRTGFLHTDRLKRNKGVVSLWTEVIIGTDRRRYRSDSHATAHTNTNHVTNHVSQNHGSPGHVNFGHVPSPSGSSNHGNGHGAYGVGHASQSSSPGNHSNYSYHGNPNHGASHINNHVTAGSSHTSGGLSEKQLMKLREEALLPSEPAAISSPSLDAFPSAPEYAIGDEVAGSSAGPSAPSAPAHTIAGVVASAPLTPSDKHENELLRLQGLSSDPYADEDHVPQYKEKEKAPEEVVAMQLNELASVPPIEGEIEEVGNSANAPSAPVMNGHEGGFFDAPSEFSESSAPPVVHGHVHGHVHGHSHSSTGTIVSGDASASAPAPTSIRSVSTAPSDTPTAPPVITHGFTGPVGPGVVDPGTSGTASTTVDSLNSEISSGTPASTLPDTNKSLSDSDDIYS