lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Together with DAAM2, required for myocardial maturation and sarcomere assembly. During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAICASVPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLLSGILPPPPPPLPPGGPPPPPGPPPLGAVMPPPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSSALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELQDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSSRERPITKLNF
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MGSGSRVVLCKTSSSLNLFAPAAFTASHLSFKSFLLSSPATNYRLHHNHRMATEASSSASSVNDGDNVIPSLANDAAPSSSSSAIDFLSLCHSLKKTKRAGWIKRDVKNPESIADHMYRMGLMALIAPDIPGIDRDKCVKMAIVHDIAEAIVGDITPSDGIPKEEKSRKEREALDHMCKLLGGGLRAKEISQLWMEYEENSSPEAKIVKDFDKVEMILQALEYENGEASS
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Mediates clathrin-dependent trafficking of vacuolar cargo from the trans-Golgi network (TGN). Promotes plant growth. Involved in the regulation of membrane trafficking and cell separation during floral organ shedding and abscission. Prevents abscission zone (AZ) cells enlargement. Exhibits ARF-GTPase activity toward ARF1 at TGN.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalizes with AGD5 at the trans-Golgi network (TGN). Colocalizes with clathrin at the TGN.
Sequence:
MNEKANVSKELNARHRKILEGLLKHPENRECADCKTKGPRWASVNLGIFICMQCSGIHRSLGVHISKVRSATLDTWLPEQVAFIQSMGNDKANSYWEAELPPNYDRVGIENFIRAKYEEKRWVSRGEKARSPPRVEQERRKSVERSGPGYEHGHSSSPVNLFEERKTIPASRTRNNVAATRINLPVPPQGPSQVIKPQQKMESAATPVEREKQAVNVAPASDPPKVDFATDLFNMLSMDDSTTNTSEATPGDTPADDNSWAGFQSAGSGQTAEKIVTAKPAESSSPPASSSDFEDLFKDTPNLTTQQAPKDVKGDIMSLFEKTNIVSPFAMHQQQVAMLAQQQALYMAAAKAAGGTPNGVNQQAIANALNVASANWSNPGGYQIPGMTNPVGGQADLQKLMQNMNMNANMNTRPAQPQENTLQYPSSSFYTMGQANQVNGMTPNSTGKPQSSSATQPTSTTPSSQSGKDFDFSSLMDGMFTKH
The following text describes a protein:
Function:
Possesses acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Exhibits strong acylation activity on lysophosphatidylethanolamine (LPE) and lysophosphatidate (LPA), and lower activity on lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Exhibits acylation activity on both LPE and LPC. Has a preference for 18:1-LPE over 16:0-LPE as acceptor. Palmitoyl-CoA (16:0-CoA) is a better acyl donor than oleoyl-CoA (18:1-CoA). Among several different acyl-CoA species the best acyl donor is palmitoyl-CoA (16:0-CoA). Activity is calcium-independent. Its activity is essential for maintaining adequate levels of phosphatidylethanolamine (PE), LPE and LPC in the cells, which is crucial for plant growth regulation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
Sequence:
MESELKDLNSNSNPPSSKEDRPLLKSESDLAAAIEELDKKFAPYARTDLYGTMGLGPFPMTENIKLAVALVTLVPLRFLLSMSILLLYYLICRVFTLFSAPYRGPEEEEDEGGVVFQEDYAHMEGWKRTVIVRSGRFLSRVLLFVFGFYWIHESCPDRDSDMDSNPKTTSTEINQKGEAATEEPERPGAIVSNHVSYLDILYHMSASFPSFVAKRSVGKLPLVGLISKCLGCVYVQREAKSPDFKGVSGTVNERVREAHSNKSAPTIMLFPEGTTTNGDYLLTFKTGAFLAGTPVLPVILKYPYERFSVAWDTISGARHILFLLCQVVNHLEVIRLPVYYPSQEEKDDPKLYASNVRKLMATEGNLILSELGLSDKRIYHATLNGNLSQTRDFHQKEE
The following text describes a protein:
Function:
Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKIKKIPWLGHFDDRGHRLSIFSIHIHPDGSRIATGGLDGTIRIWSTEAINRENENENENEDLPKQLCCMSTHTGTVTSVRFSPNGQYLASGSDDRVVIIWHKEEAIPGLGSTFGSGEKHTENWRSYRRLLGHDNDIQDLCWSYDSQLVVSVGLDSSIIVWNGTTFERLKRIEAHQSHVKGITFDPAGKYFATESDDRTIKVWRVSDFSIEKTITGPFNNSPLSTYFRRPSWSPDGKHIAAPNAMNGPVSCVSIIERGTWTSEINLIGHEGPVEVTAFNPKLFRDKNDKLVCILACGGQDRSLSIWSSALPRPLLSCQNVFQKSIGDVCWSPDGLSLFLCSYDGNVLVCTFEKEEFGDMVSDEEISKALAKYGHGRHGIVLPESAKQLELEETAYAILKKPSSLSTTDPTLVPQSSSTPKSAQKTPQKLPAFLPNRLTAETVDTNKLTASKEQIASPKRPGPSDNGNEIPTKFVQKVTITKEGKKRVAPQLLTTLSATPSTSRLASTQLQHTGSSQLPPQQFSQPINSLPKGGVPILIVGNKTKVNHENDESDQALQEEKIEEGLLKNYYSSLIDSSTSISNINFEAPRYKTNIVHSLNNEQKYVLEVKNGTSEKNPTRIVALENGNTKWMDYLPRPVILVTGSIHFWSIACDDGSLHLYSLTGSRLLPPIMIESKASFLHCNNAYLLCISSSGMVYAWNVVNKTALFTANSLAPILSRVSNNVTIENNSTDIPHVVIASISKEGVPSVTLSTGETYVYSSTMLCWQRITEPWWAIGSREWDSSGLLQSNTQTESQPLKIYEHRTNNVLMDSGRGKLLQKMVADAITEEGYDDFETIVTINHLENKIASARLLKLDDEFLVTSEVYVRLLMHHGLWQKLEEFLGELRTQTKCSIKLSGREVVAKMLVVLRQAVQTDNEFDRANKLIEKYAST
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MSRVVIGFLKLTLLAIILVAFDASEAQTPLKMGFYKTTCPTAEQIVRDTVNSAVTANPGMAVGIIRLFFHDCFVRGCDASLLLKPVRGSEGKSEQDAGANAGTLRGMEIIDQAKARLEVVCPNTVSCADILAFAARDSTNIVVNLPSPGSDLDTLKKKFMDKGLSVRELVALSGAHSIGRAECNFVASRLYFFNGNGTDPSLDPEYATTLKKKCPKNQLSRTTELDLVTPNRLDNQYYRNLKKQPVLFSSDEALVDSTITAATVTNYANNPIAWKKDFAAAMVRLGSLDVLTGTRGEIRKKCGVVN
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDLYGLQTSDFFRIDDLLDFTNDELFSSTTTDSGNLPPPEIASGNRSLAASGNRDQPNTFHSADFTDDLCVPSDDVAELEWLSNFVDDSFADFPENELAGTVMARPDSSFPGRTRSKRSRASSTNKVWTSLPVSEIPMIGKSKTNSNKNSIVKKESSSSSSVISGERSSSSSPASSPTGARKCTHCASEKTPQWRTGPLGPKTLCNACGVRYKSGRLVPEYRPAASPTFVLTQHSNSHRKVMELRRQKEILRQQQQQQQLYHHHHDFEVC
The following text describes a protein:
Function:
High-affinity transporter for the intake of thiamine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDVPGPVSRRAAAAAATVLLRTARVPRECWFLPTALICAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLSMYQKVTSYCRSATLVGFTVGSVLGQILVSVADWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHVPASQGMNGIKGSKPDRLLVLRVLWNDFLICYSSRPLLCWSVWWALSTCGYFQVVNYAQGLWEQVMPSRHASIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGELTLSVFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAASLSMERYALVFGVNTFIALALQTLLTVIVVDASGLGLEITTQFFIYAGYFALIAVVFLANGAVSIMKKYRKQEDPESRSQVTTS
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MFPYKQTQPSETVAPQLHPELHTICRTCLQQSNDTRSIFDLDQTTQLTYSEKVMQCVDVEIYPHDSLPNRICRQCVDDLDVACRFRANCTSSSVVLQTYLSYNGLEEKQLDMMLQPTLAQSVHSDPDDGDEIAIHLDSGVMYTYKPPSGLDVKLVHHSAEDVIFNSGNMKMESLNGNANVPVEEPVNSVAETMAMVEPMHHSSLDGNITLAMESAEATNNDHIEYMFEVVNEPETDDSMLEPAVDVMHVQNTATADRTLRKTTNSMTPDSTNTHSNGKQYSFANRTNAASVKTLQTIRKSHTPNETKPTIEAVTTQPAADGSGVETVIRVKRNLSAPKPSLVCKLCNVTYKHKHALETHMRRHRGDRPHKCDYCEKSFVVPFELQRHMRIHTGQKPYKCQYCERAYSDFGSKTKHERTHTGERPYACHYCDKTFSYSHVLNSHLLVHTGVKKYCCSICGKRFTKSHHLKTHYNTHQITNTDVGTVQGSEIEMPNNSNGKQQSTDVIYTEQLQDELIASKDEQQSSGNGGVLVDSYHHGTGPGLIAATEWTTMVHNNGGGSGGGSATSAAITTEELENVSIVNFADYIIKSDGLDDLLVVQDSGDDELVELVGQPIMHR
The following text describes a protein:
Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGGYGSQVMTMTVTNTPSADLAFTNLAYCSSSDLRHIRDGSIALNAIQRRHARVSTGDMVSVSRFVPPENFELAMLTLELEFVKKGTKSEQVDAALLSTQLKRKYINQVLTVGQKATFEYHGTNYILTVNRADVEGQNQSNGIERGMLSQDTYVVFEASNASGIKIVNQREAASSNIFKHKEFNLESLGIGGLGAEFADIFRRAFASRVFPPHVTSRLGIKHVKGMLLFGPPGTGKTLMARQIGKMLNGKDPKIVNGPEVLSKFVGETEKNVRDLFADAEQDQRTLGDASELHVIIFDEIDAICKSRGSTRDGTGVHDSIVNQLLTKIDGVEALNNVLLIGMTNRKDLLDEALLRPGRLEVQVEISLPDEAGRLQILQIHTNKMKENSFLGHDINLQELAARTKNYSGAELEGVVKSATSYALNRQLSMDDLTKPVEEENIKITMEDFLHAIHEVQPAFGASTDDLERCRLNGMVDSGDRHNHIYKRAMLLVEQVKVSTRSPLVTCLLEGPSGSGKTALAATVGIDSDFPYVKIVSAETMIGLHESTKCAHIVKVFEDAYKSPMSIIILDDIERLLEYVAIGPRFSNIISQTLMVLLKRLPPKGKKLLVFGTTSQLTFLDSVGICEAFSITYSVPTLRTEDAKKVLKQLNVFSEDDVEAAAEALDDMPIKKLYMLIEMAAQGEYGGSAEAIYDGREKIKLTHFFDCLQDVVRF
The following text describes a protein:
Function:
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.
Miscellaneous:
MISCELLANEOUS: [Isoform 5]: Less effective in the NF-kappa-B inhibitory effect.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
Sequence:
MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELTGKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKASGERYHVEPHPEHLCGAYPYAYPPMPAMVPHHGFEDWSQIRYPPPPMAMEHPPPLPNSRLFHLPEYTWRLPCGGVRNPNQSSQVMDPPTARPTEPESPKNDREGPQ
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
Subcellular Localization:
Nucleus. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage.
Domain:
The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
Sequence:
MAVPKDAIPSLSECQCQICVEILFEPVTLPCNHTLCKPCFQSTVEKANLCCPFCRRRVSSWTRHRTRTNSLVNMELWKIIQKHYPKECKLRASGQESEEIVDDHQPVRLLSKPGELRREYEEEISKVEAERRANEEEENKASEEYIQRLLAEEEEEEKRQAENRQREMEEQLKRDEELARKLSLQINNFCGGSVLALPLNSKKSDPVTTKSQKKNKNKPTNTGDIEKYLSPKSQLGSASQSEVVQEDRKNSVSKETDSSGMKSPTWQDTDVEEDMPTLSPQICPEVQEQGVKPSMESPMPQLYASGREWCLEGQMETKASNHEKELCVINHEGPKARVPDSEEAAVKTCGKTESGFTVSDTTPIIRNNTPEIENEESNLLINKDIFKRKNQESLFEAVRDPCSSAKRRKMFPTASSDEEETEISFTQKLIDLEHLLFERHKQEEQDRLLALQLQKEVDQEHMRPNRQRGSPDGYQLRATSSPPDRLLNGQRRSSKDRNFKRQTDLEHPKPQRGSKNENWQTSFKIQWKHSVNGRNIPNSIRDNCSVPKTAQSLQPTCACSECRTTIQAAAGEPRN
The following text describes a protein:
Function:
Catalyzes the dehydrogenation of D-proline. Can also use other D-amino acids, but with lower efficiency.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKVAIVGGGIIGLFTAYHLRQQGADVVIIEQGEPGGWSKAAAGILEFTRFVINRINVRSYPKRYLSMALRGDARIKTWDWRWISAYLRAWGREPTQDMWEAIKTLGEYSWRQYRALAEAENDFAYSEEPLYEVGIDVAAALEEAKRDPLSPKVETGRCCGREALVYLDAAKLSTEDFVARMLRELQGVQMVRRRAQEVAGREVWLEGGDVVKADAVVVAAGYWARKFGIPVAPFKGYGFRTTAKAQSMFIEMTKGVAVVPLPKWTKVTGRFDLDGTEDHSPSARVLQRAREVLGNFEVLDMSVGYRPCTPDGFPIVDKVGEVVIVTGACRLGWTYGPALGKLAADLALGKPGVEALTARRFRR
The following text describes a protein:
Function:
Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MVQAPMISVPLKATSEIDWVAPLKNYIRNTYGDDPERYAEECATLNRLRQDMRGAGKDSTSGRDLLYRYYGQLELLDLRFPVDEKNIKISFTWFDAFTHKPTAQYSLAFEKASIIFNISAVLSCHAAHQLRTEEAGLKTAYHSFQASAGMFTYINENFLHAPSSDLSRETVKTLISIMLAQAQEVFLEKQIADQKKNGLLAKLSSQAAALYAQAVEGVQENVTKAIFEKVWLSVVQIKLNFMNSLAQYYQALADEDANSYGVAIARLEIAQGLAKEANKMAHSFPTSVPPNSNLTSDCGHILADATKRHLATVKEKLEELNKENDMIYHQPVPAEASVAPVPKLPAAKPIPVSELYAGQDIQRITGPDLFAKIVPLAVTESASLYDEEKAKLVRAETERVETANSEMAASLDYLRLPGALQVLKGGFDQDILPDEDFRTWCVDVADHESPHRIFEYLHTEKQAISTILDKSSRQLDMEESVCEKMRSKYDAEWTQQPSSRLTTTLRTDIRRYREALEVAAKSDGQLATKLRANETELDEMRQAAQHGEIDELFQRAVRKSRKSNPNSPATVEPNLLEADFDDGGPSVVEQIQKVEDILKKLSLVKKERLQVLQDLKQKAHSDDISQILILNKKSIANYEQQLFQQELEKFRPHQNRLVQASHKQAALMRELTVTFNNLLQDKRVRADQSRYESVQRSRTSVINKYKRAYQEFLDLEAGLQSAKNWYKDMRQEAESLEKNVEAFVNNRRAEGAQLLNQIEQDRAANKSSHAALEQERLKNLMERMSMDPSPTSPKPSSGSGGRPTPAPLSFAPAAVSNTPLSAYQKSNFSTQYPASPPATQVPHNPGGQQQTPYQQYNPSSLGRIPGPASPPPNQTSFNIGPGRHPASPPPTQTSFAQSRPYSLTTYGNPSALNPQGGQPQQSQPGGYVPPGFVPPPPPPGPPPLGPQQTVHYGGNEYYAGAMGNPNIGRPGSGQQGPQGQQGGWGQPPPQQQLYQQQGGGGGDPWAGLSAWK
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MKRVGDYILDKRIGWGAFAQVYKGFSIKTNEPFAIKVVDVCRLADKNSKLTENLNYEIRILKELSHTNIVRLYDVLNEETDPTFIYMIMECCEGGDFSKYIRTHKKLTEEKALYFMKQLANGLKFLRQKQIVHRDLKPQNLLLSDDSEHPILKIGDFGFAKFIDPFSLSDTFCGSPLYMAPEILHRKNYTVKADLWSVGIILYEMLVGEPAYNSGSVPDLLNQLQNKKIKLPSHISSDCQNLIYSLLQIDVEKRISWEDFFNHKWLNLNNNDSYKNNSGNYFNNNNINNNNNNNTNNNNNNISYPISINSNNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYYNNNNSPPNVYHASSLPYDFNNNNNNNNSNNYNNNTNVPNSLPFAYNNNIYSSPTEAIPQPTTLNKSKSLENTGNTIRAHPFKDDKKSTTIQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQNRQLSNLSTDFERDLVILDGEELESMERVFNRAVAIAELGDLRQNEPLECVPLYILALKLMKSKIPNDPSSSPDKFINTFTEYKRKLVHIFSTSNTSVKNQDHHSSFSPNRFIYENALEFGKKGAVEELYNNYPTSLQFYTDGTLLLEYLSSIVIDSDDQEIIKKYLNAFEVRTQICKKNYENSKNTVLNTNSIQNNT
The following text describes a protein:
Function:
Catalyzes the transfer of an N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol (MSH) biosynthesis pathway. MSH and WhiB3 are probably part of a regulatory circuit that mediates gene expression upon acid stress (like that found in host macrophage phagosomes). MSH is one of the major redox buffers which protects bacteria against redox stressors and antibiotics; loss of MSH or ergothioneine (ERG, the other major redox buffer in this bacteria) leads to respiratory alterations and bioenergetic deficiencies that negatively impact virulence.
Sequence:
MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA
The following text describes a protein:
Function:
Recruited co-dependently with zhp-1 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination. Together with zhp-1, promotes the accumulation of pro-crossover proteins, including zhp-3 and zhp-4, at a designated crossover site along the recombination intermediate. Limits the number of crossover sites along a recombination intermediate by restricting the association of these pro-crossover proteins with other recombination sites during late prophase. Also, together with zhp-1, plays a role in chromosome remodeling following crossover formation to promote two successive rounds of chromosome segregation during meiosis.
Subcellular Localization:
Chromosome. Note=In association with zhp-1, localizes to chromosomes from pachytene to early diakinesis in the germ line. Co-localizes with syp-1, a component of the synaptonemal complex from early prophase to mid-pachytene. From mid-pachytene to diplotene, co-localizes with syp-1 on one side of each crossover site. Remains co-localized with syp-1 along the short arm of homologous chromosomes through to late diakinesis. At late pachytene, localization at chromosomes is not dependent on syp-1.
Sequence:
MDWIQCNHCGIKPNQTKLYLTACGHVFCQNCTKAAFNSQCYLCKKPLKVDEINKNLRPDLMELFKDPRQLASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEEKNQLMARLKELREQPSQNLSVNKRRSNTRTEPPFSKISRTGPPSVMRKASHEFSLNLRDQSTSKILTSTPLSNIDYSRRDHRNRLFGAGLEHPSPILRQ
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MNNFAIHLVQYIGFSLAQFTNLLLLYIIANKAKKLLGGYRYVMIVFVIYSLFYSWIEIAVSPLMYAHRSMFIIMVGSSLRYEELAGTFIVCLFCAAYSLMIALLATQFFYRFIAVCRPQCLYMINGYKLCLIFIPGVVIFFLWYFNVFFGMRSTFEKAEYMRNVVLDIYEEDTFQIVFVALQYWEDDLNGKSHFRMIDFVCYLGFLLMIASCFLTIVFCAMKIYFKLKEDLNSMSVRTKELNRQLMMTLMFQTIFPFFTMYSTVGTILTVPIFEIEVGKLANIPGMFASIYPAIEPIFAILCVKEFRNCVLCKKHFVSNVIPLQHSPIPRNSLMTAHASLQNSSNL
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.
Miscellaneous:
MISCELLANEOUS: Present with 1320 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDEDNNYDDFMLSDDEGMESIEMEEETDDEDKQNIEINEDNSQDDQDRGAARHKQHEQGTFEKHDRVEDICERIFEQGQALKEDERYKEARDLFLKIYYKEEFSSDESIERLMTWKFKSLIEILRLRALQLYFQKNGAQDLVLQILEDTATMSVFLQRIDFQIDGNIFELLSDTFEVLAPKWERVFLFDIEKVDRENMICKIDFQKNFMDQFQWILRKPGKDCKLQNLQRIIRKKIFIAVVWYQRLTMGNVFTPEISSQIEILVKDNECSSFEENNDLESVSMLLQYYILEYMNTARINNRRLFKKCIDFFEMLISKSLTFSQESGLMVILYTSKIVFILDSDSENDLSFALMRYYDRKEELKNMFLYILKHLEEMGKLRERDITSLFHKFILSGFIFTSMILEAISTDKINPFGFEQVKIALGSPIVNVLEDVYRCFAQLELRQLNASISLIPELSVVLSGIIQDIYYLAQTLKLWRKIARLYSCISISDIISMLQISDDNEMTRDDLLTILMRSIMKNRSVVYFKLDLTSDLVYFGDENKVMLPRCSKEEFRLMISPKDEETTEKARLIDFEYVNDVAIYNNPTRIRTKSSKEFFNTLRKSRETVKLPRVSNQSNEDTFLPSYMKFSNKYLELCKLASNNLE
The following text describes a protein:
Function:
Probably involved in an RNA processing event other than mRNA capping. Releases gamma-phosphate from the 5'-end of RNA to produce a diphosphate terminus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSDQPETPSNSRNSHENVGAKKADANVASKFRSLHISETTKPLTSTRALYKTTRNNSRGATEFHKHVCKLAWKYLACIDKSSISHIEIEMKFGVITDKRTHRRMTPHNKPFIVQNRNGRLVSNVPEQMFSSFQELLRSKSENPSKCAPRVVKQVQKYTKDSIYNCNNASKVGKLTSWRCSEDLRNKELKLTYIKKVRVKDFLIRYPQSSLDAKISISLEVPEYETSAAFRNGFILQRTKSRSTYTFNDKMPLHLDLTKVTTTRRNSHQYTSHEVEVEMDPIFKETISANDREKFNEYMCSFLNASDLIRKAAERDNMLTT
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAEHPPASEEDPLKEVLAQWENINRILKRHGCSPVSVSKAPDKGSLSGAVLLDHQASLAVTSALTSLVQDTERRQNLIHGLIQSNNQLKEDARQQQGRAARQEQRATDLQNILDSVKAKIRDLEDDFISKTRQQQNQVAELLKEKQAANEQCQKQQEKLGQLEEKVGQLKEQLSRAQSAEERRGAAQRKTFLQLLSRLPRDNNGTDQQILDIIGGYEGQVTQLQKELRKYKMADVEVSVRDRKYSQEPLNLDTTPNYRALLKSYQEQMRDAKEKREQLLRDICNLQRELEARPAPRELKLYKQQVRKLEKLLRQNNISFRGTMREKNERKAPVPPSTRVEDVDQLPTDECRRYLQEICRELGVRDLRDLVPVSSAKVREAETCAKLHRILSGIRSLLSSPQAPQLLYKGSSRGPGSSAIDPREESDFLHLLPTIEMWAGQLLSLKELYRSLHNLSEKVLPHPLPSPVPGGPASVRVEDLQLLLDSMIEDVESQKQAPGSLSPHTLLALVSHFQKLFDAPSLSGVYPRMNEVYSRLGELSNMMKSLCCLLGIDGVASSSAVVNGVWRLCRDHEGGDSRKLQQILGTLDIDSVINKIQEHEEFFPAFEGLIKALLNLLEIDQLDEILPEVRRLKAQVAH