lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Membrane-anchored forms may play a role in cellular adhesion.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Secreted.
Sequence:
MGSGLRKGLTAPRWWRLLVLEGVTWPWLGGLQGTPGSFGERWGCGAWGALGGPCGGGAILGAQPDPSCSLSPRQLLGFTCVEVSGLSTELVQELAVALGQKNVKLSAEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTHFFSRVAKANVDLLPRGAPERQRLLPAALTCWGVRGSLLSEADVRALGGLACDLPGCFVAESAEVVLPRLVRCLGPLDQDQQEAARAALQRGGPPYGPPSTWSISTLDDLQSLLPVLGQPVIHSIPKGILAAWRQRSSRDPSWQQPEQTVLRPRFRRDVERTTCPPEKEVHEIDESLIFYKKRELEACVDAALLAAQMDRVDAIPFTYEQLDVLKHKLDELYPQGYPESVIRHLGHLFLKMSPEDIRKWNVTSLETLKALLKVSKGHEMSAQVATLIDRVVVGRGQLDKDTVDTLTAFCPGCLCSLSPERLSSVPPSVIGAVRPQDLDTCGPRQLDVLYPKARLAFQNMSGSEYFVKIRPFLGGAPTEDVKALSQQNVSMDLATFMKLRREAVLPLTVAEVQKLLGPHVEGLKVEEQHSPVRDWILKQRQDDLDTLGLGLQGGIPNGYLILDLSVREALSGTPCLLGPGPVLTVLALLLASTLA
The following text describes a protein:
Function:
Required for ribosomal protein bS1 (rpsA) to bind to the 30S subunit.
Sequence:
MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEAE
The following text describes a protein:
Function:
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVKPKYKGRSTINRSAASTNPDRVQGAGGQNMRDRGTIRRLNMYRQKERRNSRGKVIKPLQYQSTVAPGTVARVEPNIKWFGNTRVIKQASLQKFQEEMDKVMKDPYKVVMKQSKLPMSLLHDRVQPHNAKVHILDTESFESTFGPKSQRKRPNLFASDMQSLLENAEMSTESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSSHIEAYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSKDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEYISKTYKIESWENAEDFLEKLALRTGKLLKGGEPDLLTVSKMVLNDWQRGRIPFFVKPPNAEMPTTPQLPPSSPLEVTTETTQNNPEEETIETEVERSDSVIEKEPEAGCSQDENSEMQQILARVRQNFGKINVGPQFSADDLVPVDDLVPVDLSDLEDLESSEEEEEQEQEQPGEDAEEECSRDTRGGPVEDDTKAVIRALDEKIAKYQRFLNKAKAKKFSAIRISKDLSEKVFAKYEEEKKASAEVSDAAPTKRARKWNAQVEEEPSDKTQRMLTCKERRRAARQQQSKKVGVRYYETHNVKNRNRNKKKTNDSEGQKHRHKKFRQKQ
The following text describes a protein:
Function:
Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRKQAARARPGGPKKARRPRQPTGGTAPKPSEGGGGLARQLRALGLKLREVPGDGNCLFRALGDQLEGHSRNHLRHRQETVEYMIKQREDFEPFVEDDVPFEKHVTNLAKPGTFAGNDAIVAFARNNQMNVVIHQLDAPLWQIQGTDKSNVRELHIAYRHGEHYDSVRRINDDSEAPAYLRMEMLSKNDSNKEEEMKQQKGDSEDETEIEIEAAIQEVCSATGCSDTELVSQVLKVEDYNVESAIFAIFQVQEVERISAEEQSDPQSEGQNPCASALCEDNGSGSRIFGSQSLHHHETENIKGQARSDEESRANKNLKVFKKQKKEQQRLEKKKRQEERHRQKVLANRSNCADNSRKEVDSDNQITLVKTMAALNI
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKVIQETPVKQAAKEAGLSIYQPEKLSGSPEMEDLMKLGADGIVTAAFGQFLPSKLLDSMDFAVNVHASLLPRHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDEDNVGTLFEKLALVGRDLLLDTLPAYIAGDIKPEPQDTSQVTFSPNIKSEEEKLNWNKTNRQLFNQIRGMNPWPVAHTFLKGDRFKIYEALPVEGQGNPGEILSIGKKELIVATAEGALSLKQVQPAGKPKMDIASFLNGVGRTLTVGERFGD
The following text describes a protein:
Function:
ABC transporter that may affect phytic acid transport and compartmentalization. May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPPSDDFQHPMEQLQALDCVRAAAFAVLLVWTLAEFLKRRKRRHQEAAAAGQGGDMASWQRGGAASIVAFCNASIALSHIGFSVLGFWKQRAVSPGLVFESASWLLSTLLLLYFKHEDAAGVVVSSNWPPVLVSWWFFSFLSESVLATLHLLRLFDSATVVVDFASLPFCTVICLVVVAMSLSKANQKELDQPLLLREDADDSSRDRFSSSGWWSRLTFRWLNPVFEKGHRVRLELEHIPSVPQSETAEQSYALLQETLHKQKPEPMPLREAIICAVWTPLVTNAVFAGLNTFSSYMGPFLITYLVELLSDKNTEKGHGHGYMLACLFFASKTVESLSQRQWYFGARRIGFQVRAALMVSIYKKSLLMKNSSTVAGKVVNFLDVDVEKVGEFFWYIHGIWLLPLQIFLALAILYHSLGAMASLSAVLVTVLVMVSNTPLANSQQNLNMKIMEAKDSRIKAMAEAMKSMRILKLHAWETAYLDKLLKLRDVERGWLRKYLYTCSAIAFLFWASPTLVSVVTFGVCILVEIPLSAGTVLSALATFRILQDPIYNLPELVSMVTQTKVSLDRIEEFIKEDYQGKPSFYGNITGTKDLAMTGEIVIEPGEYSWEADNSSKKTKVTLKINSKVSIGKGLKVAVCGPVGSGKSSLLYSIMGEIPRVSGAEPTVVGSRAYVPQSAWIQTGTIQDNVLFGKAMDRSLYEEVLQGCALDRDLELWSNGDMTVVGERGVNLSGGQKQRIQLARALYSDSDVYFLDDPFSAVDAHTSAHLFKECLLRLMSSKTVMYVTHQLEFLRDSDLVLVMNDGRIVQSGKYDDLIADKDGELSEQMAAHDQSLSQVNPAKAHGLAEIKQQKKQILTTEIESDGHAIGRECEEERESGRVKWDVYRKFVTSAYGGGLIPVVLLCQIFFQGLQICSNYWIAWAAEREDQVSKKKMIGIFVLLSAGSSVFILGRAVFLSTIAIKTAQQLFLGMIRNIFRAPMSFFDSTPSSRILNRASTDQATVDTDIPYRLAGLIFAMIQLLSIIFIMSQIAWPIFMLFIIIIAISTWYQSYYISSARELARMVGIRKAPVLHHFSETVSGAATIRCFNQGEKFLTKSLALIDDYTRITFHNSATVEWLCIRINFLFNLVFFVMLVILVSLPRDTIDPSLAGLAATYGLNLNVLQAWVIWNLCNVENKMISVERIFQFTNIPSESPLVIENCRPMETWPWCGTIQIEALQIQYSPDMPMVLKGMNCTFPGEKKIGVVGRTGSGKSTLIQALFRVVEPSAGRIFIDGVDISLLGVHDLRCRLSIIPQEPTLFQGTVRTNLDPLQQHLDTEIWEVLRKCRLEEIVREDNRLLDAPVVEDGENWSVGQRQLVCLARVLLMKRKILVLDEATASVDTATDNIIQKTIRQETDNCTVITIAHRIPTVIDSDLVLVLGEGRILEFDSPGNLLRDESSAFSKLVMEFMGRSEGRHQPELMQRHQVITNLADLT
The following text describes a protein:
Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Sequence:
MENGEDPPFEPTWESLAHYKIPEWYQRDKFGIFIHWGVYSVPAFGNEWYPRNMYIKNSAEYKHHIETYGPHTKFGYKDFIPQLTASNFDPLAWADLFRDAGARFVVPVGEHHDGFAMYDSSVSRWSATKMGPRRDVIGDLASAVRDRGLVFGVSCHRAEHWWFFNGGKSFPSDVQDPRYRDLYGPAMPDTLQPDATFLEDWLTRCCDLVDKYKPQVFYFDWWIEQPAFKPYLQRFAAYYYNRAAEWKKGVVINYKFEAYPEGCAVLDMERSHLDRIRPLFWQTDTSVSRNSWGYVEKQDYKQCKDVICDLLDVVSKNGALLLNIGPKPDGTIPQEEQELLRQVGAWLKKYGSAIYGTRPWKVFGEGPTDTSGGSDERHDPFTCQDIRFTVGAEGALYATAMAWPDDLKLTVCSVGSNLRLFGGKVESVTLLGHENLTLKWTCDGAGLHVTLPTVPPLNGAMTCTLKIVGDVKSGLNPVGPPDHGLGIKSSL
The following text describes a protein:
Function:
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Subcellular Localization:
Cytoplasm.
Domain:
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Sequence:
MTQTPVDYKQTVRTPKTDFPMRANASTREVEIQRFWEEQGIYGRLAQENPGEIFILHDGPPYANGELHVGHALNKILKDIINRYQLLQGRRVRYVPGWDCHGLPIELKVLQDLSQAERSQLTPLDVRTRARDFAQRTVQSQCASYKRFGVWGDWDHPYLTLQPEYEAAQLGVFGKMALKGYIYRGLKPVHWSPSSQTALAEAELEYPTKDDGSPAHTSRSVYVKFPLISIAAPETATVMAAELLPRLSAFHDREEELIDALLGERDDLPEIAVAIWTTTPWTLPGNLAVALNGELDYALVASDEHGLLIVAAELVERLAGTLATRFETIATFRGRELEGSLLAHPLFRRTSPIVLGDHVTTESGTGAVHTAPGHGSEDFELAQRYNLGVLSPVDDYGRFTREADSDRRENLPVFAGKAVLSDGNQAVIEALSAAGALLKEEAYVHKYPYDWRTKKPTIFRATTQWFASVSDFRPQALSAIAQTEWIPASGENRITAMVAGRNDWCISRQRAWGLPIPAFYCENCANVLLTQESVEAVQAAVRVHGSDIWWQKEASELLPPGIACAHCGGTAFRKEKDIMDVWFDSGSSWAGVLGRRPELHYPADVYLEGSDQHRGWFQSSLLTCVATEGTAPYKTVITHGFTLDEHGRKMSKSLGNVVDPKLVIDGGANQKQHPAYGADVLRLWVASVDYTSDQLVGPSVLAQIAEVYRKIRNTARYLLGSLNDFVPERDLVAFDSLGEVDQYLLHRLSVVHLEVTQAFESYQFSRFFQTIQNFCVADLSNFYLDISKDRLYISAEVSLRRRSCQTVLYRVLESLTRLIAPVLPHLAEDIWQHLPYPRSDASVFEAGWPVDHSQWFQPLTVDRWPGLIVLRDRVNIALEAARNAKRIGSSLEAKIRLHVEDPALTDELARQKDELRYLFIVSQVELLDELPAEVSVEEGAAVIVLDADGQKCERCWNYSVHVGEDAEHPTLCERCVSALAGAF
The following text describes a protein:
Function:
Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance.
Subcellular Localization:
Secreted.
Sequence:
MKFFIALALLGAALASTHLDRYNSIERNIQESSFRAGREYRYLFNGQLSAGLPVPSTPQGISRLQSQVTLQWTDGNTVRMQLQKTRFATSQQESNSMKMLPFERFEEVERMNREHQELLSMPVEFDYEHGLVREIRFAENDQPWSENIKRAVINMLQVNILKKEKYEGAEKSDNQEPTFSFTNVERTLEGECEVLYTVEEIKKEDEQRWAKSINFDKCTRRPYIHHVQTPVCKDCQQTLEQDKMSSTVLNYNITGTSSSFLINSVELRSQHLFAPISEKHQLVSAFTLNTMELIYAGEKKTEIKQVRNEKTSELVYNQESEWAEQQWAQTGEEKYLRQLPQWTENKVEMIKKMFSLMAKQIEQGEAELEAAHTVARIVKVLRECNEEQLEQIYRHVAEHKDEKIAEQLRSIYFNTLALAGTRVTIQQFVDKVQSRKNIAPLKASVAIKTLVDMRYPSLAIAEDIARLCESDVSSSFPALRQSCWLTYGAIVNGVCGQTPRVFVQKNGVKMCPRDAKQRIVDKLVQQFESASTRYEKVLALKTLANAGLDLSVYPLEKIILNEQHETTIRTQAIESFRRLRTQMPTKIQRVLMPVYLNRQQPQHIRMSALHQIIYTQPEWSVLSQIGNQLRQERNQQVRAFTLSLLRSYANNESPCEQTFSSRVQSLLNNIPFSSQEIDRFESVYGKWSTYSRRHQSGFEANFASLFTTESVLPTEMMASIEGVLSGEWNQYFAQIGFTQKNMEKIIKKLLSNVQEKGLEQIVVRGKRASGSFQPTEFLSNLLEKLRITRRQSSEQDPHAFVYIRHRDMDYAFLPIDADSIPEVVRSMIQGGRLEIGDIERVLAQGIHFSASNAAFLYETVRRVPTPMGLPVQFTSKMPTISSIRGQVTFELEPKNGKSFDGLRLRVQAGPRVASTHVLSLRVICPIAEVGTKFLHQAVLNTPVDTEIRMNWEDKVVIRAIYNTPSEEKRIAMIQSRPVTFTRTVAPDARQYPEPIEMTYMLPAHKQLSQSLDREYPQIRVQGTLNRPTSVRIPQWIVDSNVEVYYKPNVEQYEAIFELNLYNNYKMEKNYEKVYKKHNGRRYLEAEPEYDEEEHREQITKKFEWLQNEKVYQHVAKFEIKPEVVKMEVEAVCNNDFHFCKTQIRGEELKATIQYVYPQTPRTVEELKEQKYRQLVVMGEMNYGENTIHININGQQSQEQKKFVKQIEQAPEHETLLEASRLDQYQTVVEYEFEPKPAQYFARYWNMVQAYLRTQYPWTSRIETREEPSRKNMIRATINVEPRQRLTVNMTIETPMETTVLERVELPFRLPTAQIHYQPRNSRYEQKPVMEKIAHHASKQANCVVKSTKINTFDQVAYRNQFTPCYSVLAKDCGSEKSEPRFVVLMKKINEKKEWKNVKVVYGENEIEMYKTEEGLICRVNGEEIEYQPESEIEKKQYNIIWLNKNTLKFDSDDVTVQFDGVNARIHLSALYRNQQCGLCGHYDNEKETEFYDAENQENTIPKFAKSYLYKDSKCNYEREMFEKEENFQRIEKNQEEEKDQEMNYEESRREQDDEPTEQVAIVERQHEICFTQKPVLRCQNGKSQESKKQKVTSVYCLPSSNSWARRQMREIRREPLAQWPEHKLRNLRDQPQMEERTVRVAVDQKCDKFDY
The following text describes a protein:
Function:
Plays a role in the formation of the appressorium, a specialized infection structure with the purpose of penetrating the host surface, and is required for proper remodeling of the appressorium wall and vesicle secretion.
Subcellular Localization:
Secreted. Nucleus.
Sequence:
MFTKSVFIALVAGVLGVTAAYDPAHMPAKTDAKGGQTGYNDCQQRYGATNPKAKCQNIFINSVKDFCLWGPPKTNGADTVGDLEAVMVSYCMKSGYGTRLIPDGTIHGAHFLKTPSFVQITGTGDFTKIHIQAGDEGGELDPHGATGSGNPVGGQVFTRAYTGNWEQLPEWQNFMSATEYCFRACRSGPWDRQWCPHIYDVMGCLWNEPANYDRGVFEQCDGTEGEWPGVYSGSTWYQGVKPTPAAQPAGKSSNCRYYPSISNGPAIKTPSKRSVMATHVKRSPEWEEEP
The following text describes a protein:
Function:
Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway. Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling. Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition. Binds indole-3-acetic acid and may play a role in tryptophan metabolism.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MNSNLPAENLTIAVNMTKTLPTAVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILDRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGISLMCMNRTAQAGSYEGFDQSQSHKVVEPGNTAFEESPAPINEPELFTSSIPETSCCSCSMGNGELHCPSIEPIANTSTSEPVIPSFEKNNHCVSRCNSQSCILAQEEEQYLQSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKETAENRDSPVSEEIKMTCQQFIHYHRDLCIRNIVKERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPAINANTLQQERYKEIEHSSPPSHSPKT
The following text describes a protein:
Function:
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
Subcellular Localization:
Nucleus.
Sequence:
MDLGDQLTNVLSCNNFASIAYEYFEAQSQTPSSTTTKKHLQDVETVWRRHGALVYYDTKREGIWVFQPSPNSPNKPLEGDELLSQANLPAVHGVELLKKDKGMYEPSNLAPNKSIMPTSLNTPTSTSSPSPLDNTIRNAQNVNARTMQANSAQNIYDPAASSPGVKSATGSADALPFLKEVQEHFISSVQGSIVHRLCSDHGFIPLNSRTLLFPSQSPSRSMAYYQSPKVSDNAVSLVNLDINLTSLGTLLIKACSYVTPGLQSISLSNPEKLQRILSQGTELWLAPGGNPAKFYSFYDDEQLPSIQPISDLQKYPEDQSWRFHGTTIKSWQSRCLDWLSTKGFDPTSIEEGGWMFVQVLNTNHVFSNPEYADMPFPDEGAIVPWPALLCFRAVKTSSTDLQPLNADSFGHVDPLTFAEEWSMNAEKQASIILNRQQERKILEAAKEQADREAQNIQANVNSAALMEKGNNAGAMYPTPPDAVHHPGGPTPSFDGAVTTPGNPAHLFSHDLEAANPSTSIMNTIDTEHWVTSEQKHRSNSNMNFSENDNDNDNLFGEMGGDLFGDTDITDADFNFFDQPDDMQMDPPPGSPVAACLPSAHQRNISEKSPISSKPSVPQAVSQDTIMEDAQPVENSLRQSVLKQSLAKPAKDMDVEMSNTNDSLVCPAPPRSPPRIMAPFDKETVFGQLVKRTSKLNSGSSVFDKVKFEYSLAEIDEKYGSHGRFRYTEDELKPQLIDPHDPTNPESLDRRKSENKRSGSEVLTQILNNESGQYEFELDNEVESDMANDFNSVSEASDSDETLPVGLSAMVRLGMKRKRYFDEGSISSYNAFTGEYEPSPATPQSIVEPQVPIFESDPADWSLTPYFTSPEPDIQPSGLSDQDLIETAQIIADQAASGNLRVNDQISQNADTHAQAIFATRRLMTAVLKATKTCLKDVKRCTLRSYLTIPGIPVVNPALRLPPRPMPNPRAAQNTEILRSSNLFPVQPPQLEVRRGDSKLAVLPPAIHFWDNLGLAPFTGNKDVNAICIYPDIVGITENADIFLDQMRGAYESFRFGGHDRIVFPDSPKGLIHYPNDECNQGIANTNAVACLSSLKDIMAQLSKNLSSMTAEEKNIVVYFVYPIDNSFLLVNICAAFKHLFKFYRKSLSEKKLKAVNELVLQLVPLDFMAAPNSLVVPSPAEYSRLAMEVYDRCVDFASSSTTAAILLEKPLPRNIDFKLHVNPSPALLQENSCLHIAYSQSIDERWITAAWSDNRGTKQMTASYCLGRKNEPFTLLFTDIANEIWETTLDLISSKKVHWRIIIAKTAVMEQPEIDFWTGLASTESNASISLTLVTVQTDPSLRILPPQTRIPPPSMTTTQSATTPVSTPQASQSSIFSPDNPSTPSRDSTTNAPTPSEAPAVPHEPDQNSRLLDITDQTWGAVLSHRLNNSNSLLEFNPALISGYLIKNSGTNTDDPPLVMEVNIIHAEVVGNPRTFHDTLLREILGYYRGLATLARVRGVVHPVRDGRPWHVAAAEKAVKALYMLV
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLPPENILPITAEERHHSFGEVISLSVQNLIAFVSSQRPWLEFLALGSMDLPTSFSSAVSRSKVNLRHFVVNYSLITAASITLFLVSNPTALVTLATFAILWLLLCFCRDHPLVLYGRQVSDKVIFFGLIVGSFWGLWLTHCFFSLVLGVLTGVLLCLVHAVLRNPDDLFVQEEEVVVPSHFLHWS
The following text describes a protein:
Function:
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
Subcellular Localization:
Mitochondrion.
Sequence:
MSCSCNTAALRIFVRNVANIQVPSSQQVTPRALPGFRRQMTTSLPFHTRSLHTTRAARSDSTEAVSEETSTATEKPKAPKLLFRKTHAPANPNWMGEQPPRRQDHKPRELKKARRDHGAHASQEEGDHTEPTKKKNRWRDLPEEERRELYAKMGKEMPDEAERQARKQEQQQQKLRASLEEPKKHNPAHPRRESWQHQKNALKEKFPEGWKPLKKLSPDALEGIRALHKQFPEEYTTEVLSNKFQVSPEAIRRILKSKWRPDPEEEIERQERWFKRGKQIWQRYAELGVKPPKKWREQGIRPNKYWKEGEEKTFKDRQIANVKLHRSLL
The following text describes a protein:
Function:
Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.
Subcellular Localization:
Nucleus.
Sequence:
MPRVVCWHTLKSLNGYKNLSSGAETREGLRSSSPVDLPLRPRKQATAAGQRKLLSLQLLLCACTSVTDLTYWGPAGHGATAPHRSLLAIHLHLVPASSAAMKATGPHNAQTQVNPQGHAPSAEDPTGTWTVSGPCKDHPHPFLSQSNPPTRISSALPLKTDSALEQTPQQLPSLHLSQG
The following text describes a protein:
Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and/or VEGFD and plays an essential role in the regulation of angiogenesis and vascular development. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Binding of vascular growth factors leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Early endosome. Cell junction. Endoplasmic reticulum. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. Localized with RAP1A at cell-cell junctions (By similarity).
Domain:
The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGF binding.
Sequence:
MELGPLRVLTVLLCLAPVFAGLFISMDQPTLSIQKSVLTITTNDTLNITCSGQRAVYWSWPNNQSSVEKRLAVTGCSEGPFCKTLTLLRVIGNDTGDYRCLYGDSQAATTIYVYVQDYRSPFVTSVGDQLGIVYITKNKTVVVPCLGTVSNLNVSLHAKYPEKVFVPDGKSISWDNKKGFTIPSHLINYAGMVFCEAKIDNESYQSVIYIVAVVGYRIYDLTMNPHYQVELAVGEKLVLNCTVRTELNVGIDFRWDYPSIKERRATIRDLKTTAGEIKTFVSTLTIESVNLSDKGRYTCAASSGRMNMKNSSYFIIHESPFIHLEKMENVVEMKLGDTVSIPVKFKGYPPPEAKWYKNGKVINANHTVKLGYALVITEATEKDAGNYTVVLTNPTNKMQKRHTFTLLVNVPPQIGENALMAPVDSYKYGSTQALTCTIYAVPPPAAVLWYWQLEEECTFSPQKVRLGANPYACRKWKVISERKGGNQVEIKQRVVTIAGKTKTVSTLVIQAANVSALYRCMATNRAGSSERVISFHVTRGLEINLQPRSQLTEKDNTSLQCTADKFTFEKLSWYKLSTHVSQTPFGGLPMPVCKNLDALQKLNATVSNVNGENVTLELILRNISLQDGGDYVCIAQDKKAKTQHCLVKHLTVQEPLHPRLVGNLENQTTNIGETIEVLCTVNGVPPPNITWFKNSETLFEDSGIVLKDGNKTLTIRRVRKEDGGLYTCLACNILGCKKAEAFFSVQGAEEKTNLELIILVGTAVIAMFFWLLLVIILRTVKRANGGDMKTGYLSIIMDPDEVPIDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEYCKFGNLSAYLRSKRSEFIPYKMKSARFRQGKENYTGDISTDLKQRLDSITSSQSSTSSGFVEERSLSDVEEEDAGSEDLCKNPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSDNNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGDPKQRPTFSELVEHLGNLLQANVRQDGKDYVVLPLSVSLNMEEDSGLSLPTSPASCKEEEEVCDPKFHYDNTAGISQYRQGSKRKSRPVSVKTFEDIPLVTTVKVVQEENQTDSGMVLASEELKTLEEQDKQVKIPFSTLAPSKSNESVMSEASNQTSGYQSGYHSDDMDNMVCSSEDTELLCAQEASPTLPRCAWPGIYSPAPVASLPL
The following text describes a protein:
Function:
Calcium-selective channel required to prevent calcium stores from overfilling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEDKIRKYDVFCIMGLAILCGIFSEFLSWLFVYRNEKFKKLNEEVKVLYEEVQKEKDDGLLSKLDKKKDKKKKASAEELYIEKTKEMTTLKTKSNFITGLIFMCVMPVLFSLFEGLTIAVLPFKPIFPFTLLTRTGLQSKNVYHCSSTFIYTLTLMLTRQNIQKYFGYAPPAGMFGDYKMPDEQADVWK
The following text describes a protein:
Function:
Required for the recruitment of hcp-3, hcp-4, knl-1, bub-1 and lin-53 to kinetochores, kinetochore assembly, chromosome condensation and chromosome segregation in meiosis and mitosis.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Requires hcp-3 for chromatin localization.
Sequence:
MGDTEIVPLRVQNVLDSEIIRLNLWSMKFNATSFKLEGFVRNEEGTMMQKVCSEFICRRFTSTLLFDVSGRFFDLVGQIDREYQQKMGMPSRIIDEFSNGIPENWADLIYSCMSANQRSALRPIQQAPKEPIRTRTEPIVTLADETELTGGCQKNSENEKERNRREREEQQTKERERRLEEEKQRRDAEAEAERRRKEEEELEEANYTLRAPKSQNGEPITPIRFTRGHDNGGAKKVFIFEQTPVRKQGPIASSTPQQKQRLADGANNQIPPTQKSQDSVQAVQPPPPRPAARNAQFASDADLFAVPKAPPSKSVRNLAASNVDIFADVDSVLDTFHFESTPGRVRKPGRRNVSSPSPEPRHRSSSRDGYEQSRYSQRYEHDNSRWSRHNATYRRHEDESRMSRKRSIVRDDFEYSRRHDDGARRRDYYDADIQGDSKRYRGRDASSSSGRSVRFEEEHRRHGDEYRDPRGPRDYNDYGRRRNHANSRSGEDEEKLNAIVRREKELRNRLQKSQKASSSSYRHRSNSSDAEESLNEWDIENQELLDNSMMFGDGIPKRSNARKDKFVKKQATRSKPANSTKSPAQARKKKRASLEDNRDLNDSIACNRPRRSCVTPVAKKITWRKQDLDRLKRVIALKKPSASDADWTEVLRLLAKEGVVEPEVVRQIAITRLKWVEPEQNEEVLKQVEEVEQKRRRGAVARVKENVKMHEELREGGNHRAEDLQSGVESMEDYQPEDVAADQSLLALRTPIVTKKRGGTRASIMPKPVEDSPMSRGNNSTFNSPRLEQTKAKDIETNFKYVQHLSMMQARPSSRLKKSSSMNNSTYRGNKNTSISLEKGTQKALKIINRGTTIHEDDENEDNDDDDDMREEDTSIY
The following text describes a protein:
Function:
Cleaves single-stranded DNA in a dC-specific manner. The cleavage occurs exclusively at the 5'-proximal position (dC1) within a dCs tract having a minimal size of 6 bases. These specific cleavages may have a detrimental effect on the replication of host dC-containing DNA.
Sequence:
MQKTNPGLQRLFQIPTFTLSNSDLTCEMKVKIADTARYSLKQNPNQDKAEVIERCRIAVYAEFFVADWLSGYVNKGQEDVDDPYTYAWDVLAHPKYCGLRVEVKTHQTDSRWISVTTGCSGEYPYGSGINLGPILNHQVADCIIIFNTKEIHPGVIQYTPKFIGDREDLRKVVRKSNYNGWYLSI
The following text describes a protein:
Function:
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in some proteins such as histones.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTDDYSKLKSEIMDLVSEEFLKTKDDIISVMIENNKLKRAELVVGNDSLPPPPPTPSIVKIEHTTTTSNIDDLPLPPPIQEVEEEEPTQQNIEQQQQTQDESDDYYKTVHPLGVQDTYEDEEYFSSYSKISLHHEMVFDKRRTAAYYHAISKSKNIFKDKVVLDVGCGTGILSCFVAKAGAKKVYAVDASDMAHRAELIVQQNGLADIVTVFKGKLEHIAFPEYVDVIVSEWQGAFLIFESMIESVIYARDNLMRPGGIILPSKASIYLSPINVDSFYNQYINQWSNVFNLDMSPLIPFAQEELLEEKTIRNYYVDNQDSVLDKPIILRTIDLSTITIEDLSKTVKTFEFQVPNGSKYHGFGSWFSVWFENLDDDDDDNDNNNNNNDNSNDDENKQQFAYYTIDRDGELVKSTYQQYSIDSKGLTPLFFKQSSNVLELSTAPGTGDQHWKQVLFLNSKEKILQSSDKQLDTTSIKGTIRILQNKDYRRHWWIEMYVSLKTNPFDYSYQKYLI
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
Sequence:
MIKVTKDLVLHLENLARLELSEDQRESLMKDFQEILDYVELLNEVDVEGVEPMYTPVEDSAKLRKGDPRFFEMRDLIKKNFPEEKDGHIKVPGIHR
The following text describes a protein:
Function:
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence.
Subcellular Localization:
Nucleus.
Sequence:
MNNSEDSGSKCSPAPISSFTIQSILGTSNDGVRSAGKDSPKSQPRKRTLSVSSEDDCSAGEDSGDCYCSEPGVPESCNPHQPLNFCLGATKGLLPVQDGIDRRPHLTPSILPDYKEEQGRACSQMSPVSEDRQRDGPDKQNNSAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVGMPLVFRENSLLRVPVPRSIAFPTPLYYPGSNLPALPLYNLYNKIEY
The following text describes a protein:
Function:
Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and PHO5.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MLLFEQPVDLEKNNEDDTNIKPFAISRHFLLKLLLCGIILIELLLYSKCPKPIDNGPRTIANRSNTYFNGTHDFKTLTILISIDGFHPRLIDAKYTPFLYNLHNLRSPYDMNITTAPYMIPSFPTQTFPNHWSMVTGKYPIEHGIVSNIFWDNFTSSEFRPNNLDARIWSNTADPIWQLLQTESQGEYKVATHMWPGSEVVYEDHGDVPRERMPFYFGKFNQWEKLQDKLAQIFRYIDMPQLKDRPELVISYIPNVDSYGHSFGYDLRDKRLQKLIGEVDGFFLDLIEGLQKRNLLKISNVMIVSDHGMSNVNANDGEHVVVWERVFPADAMSAFISHLYNEGPMMMVCLKNPRDKQWICDLIEAQLEKAYGDEISRKFHVILKEDFDPSWKYFQYDNRKHRYDDRVGDIWILADEYYAIVKEMGDVPIGIMGTHGYNFNNCSDMASIFIGMGPMFNNEVVPPFENIEVYNMLIKASALLGEEKTKKEKSLLQ