lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Nucleus outer membrane; Peripheral membrane protein.
Sequence:
MDDLESEFNLKVVLVSFKQCLNEKEEVLLEYYLAGWRGLVRFLNSLGTIFSFISKDVVTKLQIMDQLRSGPQQEHYSSLQAMVAYEVGNQLVDLERRSRHPDSGCRTVLRLHRALRWLQLFLEGVRTSPEDARTSVLCTDSYNASLATYHPWIIRRAVTVAFCALPTRKVFLESMNVGSSEQAVEMLNEALPFIERVYNISQKLYAEHALLDLP
The following text describes a protein:
Function:
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLKFIQNNREITALLAVVLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGMLLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVSAIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGLEMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALERNLRRQKYARFMTPPPSVKPASSGKKREAA
The following text describes a protein:
Function:
Transcriptional regulator that represses the expression of the lsr operon (lsrACDBFGE) in the absence of the quorum-sensing signaling molecule autoinducer 2 (AI-2). It also represses the expression of the lsrRK operon. Acts by binding to the intergenic region between the lsr operon and lsrR. In the presence of phosphorylated autoinducer-2 (phospho-AI-2), LsrR is inactivated, leading to the transcription of the genes. The regulatory function of LsrR was thought to be limited to the lsr operon, but it was subsequently shown to be involved, directly or indirectly, in the regulation of SPI-1 and flagella genes. It negatively regulates the expression of those genes, which reduces the ability of Salmonella to invade host cells.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDNTLVSDYGMCEEEQVARIAWFYYHDGLTQSEISERLGLTRLKVSRLLEKGHQSGIIRVQINSRFEGCLEYENALRNHFALQNIRVLPALPDADIGLRLGIGAAHMLMESLRPQQLLAVGFGEATMTTLKRLSGFISAQQIRLVTLSGGVGPYMTGIGQLDAACSVSIMPAPLRASSQEIACTLRNENSVRDVMLTAQAADAAIVGIGAINQKDQASILKSGYITQGEQLMIGRKGAVGDILGYFFDAHGEIIPDIKIHNELIGLKLNSLSTIPTVIGVAGGEQKAEAIIAAMRGNYINALVTDQKTAGKIIQIIEK
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MTIQEGTGVAAKKKLKVGKKVAPADNQTDVTFKTQKISLRPQKIAMDHEEAATAAGKQQRFKDLLAQCRHYNTQSRKEALAQIQDLMAVADQEMISLNLGTIANDIIALILDETNSVRAALIAFVTSFFGRVDEISIMPFDAVIVAYTTSAMSHISDSIRVDGLCLLKLLILQFPKIISKNSHSILPHFLDLLSSHTRNQDSRGATFGINSELITFKGRERLLDSFYGFLCLVILPTKSNLRDQKVPGGTHGEIEWNKIENRNQKVPHLDSLFTETVVFKSNDRLTVSGVSATKTIKFRSHSLVTEANVQLQPNSLSKCRIAFSKHVSPFFPFGEACSLLDDKLYKTLMQMNLGYCRIILQMLGQENDDTQMMAGMKQSVSQYVVHTLQSSQSLTAYASNLDMEVLDKIVFELYTKFHDLNTLQAMIGFQNTTKSMQLAYNAFSILARLDNALGSEDYNKWACGLPFQLYQLKIWNFEFSKAICDFLTLIVKSGSAELGHTIMAKIVPFFYGSAKKSKPPQFGPFKDLPETVQTAAVALLYYLPKWNEEMIQAIVECFTLWTPATLVVISLLDVANTRQKTLELALSHSVYASLLMTLGVGYTKSSLKPIHTDSLGTTKSYIVTVESFCNTSERHTQMNKDQLLSTLWKRRQDIVRAISTLVDSKPFFTRLTDMLTTTLPVDGYLGVFSLLSCITEPSLTKIVMDFKLHSLLSVRLTEFEQYIVSRTTTQRVNTNSKWIDFDLAYG
The following text describes a protein:
Function:
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDIESDHEPKESSVDLEGRHDSIRKSFEADDIDVTDENTIFSTSRKEQSTIEPMDSFVENNIANSSSQQSVSEIDIQLPSSEPKEGVKEESNLIESNSLDNVQEINPQNTIGDKSAHTEEESSNDNLVKITAGTIISDIMDEPVVDEDDKLSEEDLSKEDLETTLKGDENYSSSQKEIYDNDETIPKPPSPEVEKIETSTSVENAYITNSQYNDTLDMEDQTSDLITTFEHENEDHEVHEVPSIHGMEGTFETVNLTSEAGNEKEFNNDSVVLNTTPKEMQISSLDAVDKLEDKPVSNDNIKANIESSTTVDRASSQLESENNESTFFVHNQNSSGQHQTLDFVASKPVTDTPELSKENTLVSSENLNDPKPNLPETEVDFGEPLEVEAPSFVVQNNSAVQPTTQKTSEDSTDLHTNEIPNVAQPPSSFEKENNKDTSKLENPDISSSPLSPTEDLFPNDPEEENLFSAALGLNSNTGSQPSETQSKPSIDPSESITVTDNQDSLLFSQLTNNALQAENATKVSENTINDEELIDDSEFTSLMSNFLESSTVQTNKYLPKSSASPPANAPIVSSDVHKNENAGTARRAPQSGAFVASKAKYSSPYDLPEEIVQVAQQKRSVSQNYNRQYSFQPRPATPSNPPRSLPPPSGQVNAPMSQTPNPISFAYQHGTPLATPTMRANSFNSYPASSAEPIRRPATTTVGHTPNLYSPKTNTYNSRHMAYEMTKSHINVISPGPSLQVNAPYTPTSGELGNKVSNPTKEFVSTSSYAPAANTRNAIIREPGILSPLSPRVQPVLSRRESIISMGSSASSYVPLEIAPRPMSSLEHTMNSAMSPGNLQRTANLYKPMTTPNAYNIKNSNQRETKYPYQPQAINYSEVTQPGSSSLPTSGEEANIIRSPGFTPLAAQKDATIYTPSHAQATLYGNMDNNDRDNEGIHDILQSDMEPVLPPHNSAYHANAPVSSHSEGLNNRLPISPLPPQLHKTGTPSHQHGFDTAETTAKQYAPSIPPNFNPNVSIDTMTEGVALPSATLDSDKSSLHKRSAELSRNNSPRPDFLPLPNQPLLHSNLHSPVSPVVDSNEDSRLKFLSTQRPAFSFGPCGTIVMAFSTPSGLYTTSGKGTKFIAGPIKIEKLGDVLTDEYRHLKEFKGPYLASNGKVDKHGKAEAIEWLSKYIDRLNQSLEYDDKNITLKDKLLLLQCLKMLLEVSDRKLIVEKLRPILLPSFEIPEPCNTATSVQELINPEINQDDSPIVASRYCTTSFLHRFYEYLLSGNKDEALTYALQQKQWPYAIIVAHSIDAKTFQGVVRTFCKSEVKESMLRSGVGVNLQLSLQLMSDAHASSMSEFSSSTSLLNLADQSQASNALVAWKELLYNIIANHYSDQKEALRVLGTLLLQENRVYAAHLVYILSLSPDVCSNKSNSLFELVGLSKHNLYPSHDDLFDVTQLTEVLELVFNVYSEKTPVFFTHLVPYRLYEAEVLAEAGEVSAARKYCELIGNYLNRVAKKSNNVDPGFVLRVRDLTQQILENSAGSEDISSSWLGRTVSRPRLDTVLSSLGSKFSKFVAGDPNFDVMRPATVGPGPFGKVASQKNLTVQTNTNNAAMESFYSDRPTSSGPSYQNRTPLTGQESMNMGVYSPYRRSTEIAENMSMDGNAYPYTPASQENPYTPRHSQEDNASVLSQQPLTFYSNVADNSYMPVSASQEPKMGMGTAFNMPTNEVHGVGAEMASPYQPLQPASAHLPNLQPTLAPINQNAYVPSNIAPAMGAMQSAPSAEAVAAPSESLNLNKDRSQQAKQAAAQNVADLVRQEEEKEKQKQKAKKNAESGKKGGAKGWFSKLLRRDESKDQPTVYKAKLGEKSHLHYDKELKRWVNDDGSDLSNQAAPPPPPPMALPKAGPPSAAPTSALPPAGPPAGATAISGNPGMPAPVPLTGKETAVPLSSMPNAPPSVASNAKLPPASNNRKVDPLEDILQAMPPPTTRKARGKTSKRYVDVMRNS
The following text describes a protein:
Function:
Transmembrane protein required for the axon guidance of a subset of ventral nerve cord-associated interneurons and motor neurons. May function with the netrin receptor unc-40 in axon guidance.
Subcellular Localization:
Membrane; Single-pass membrane protein. Cell projection, axon.
Domain:
The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 84 and 106.
Sequence:
MDLSSWFEFTMYDAVFLVVVLGFFFYWLTRSEQPLPAPPKELAPLPMSDMTVEELRKYDGVKNEHILFGLNGTIYDVTRGKGFYGPGKAYGTLAGHDATRALGTMDQNAVSSEWDDHTGISADEQETANEWETQFKFKYLTVGRLVKNSSEKADYGNRKSFVRGAESLDSIINGGDEGTKKDN
The following text describes a protein:
Function:
Channel-forming protein essential for import of protein precursors into mitochondria.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MSAPVAPPQAAVYPPGVQSPPPSGAERVGPGAPSPFVDEKRTAYPSGLTPPISSQPSTSMFGFFQPIVTPVSNALARIQDIRTRLELSNPGTVEHLQREVKGVHTTNFMFDGARADLTKAISINPIFQVTHAFSMGSQAAPSSYNFGAVYGDNKNFFQAGLDDGLNVTMRANRGWVAGHTTKVQAQLTATPGQSFVQIEHDYQGTDHSANFKALNPSPTDLTGIYIVNYLQSLTRNFAFGVETVYQRPSADMEEASTGYIAKLTGDKKDWIATAQVQPQGVAQCTYYHKLSEQVDVAADLQMITMAQKREAAATLGARYNFRMATLRAQIDSAGKLSSVYETRLSPAFGLTFAGEIDHLQGAAKFGFGVSIESGNEMDPNAPPPTPPSVPM
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPSCSCAASGSCTCAGSCKCRVQMHLLQEKLLFLLPRGLCQVCPGLLCKGASDKCSCCA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ceramides into sphingoid base and free fatty acid (By similarity). C.elegans contain specific sphingoid bases, which are unique or different in structure compared to the sphingoid bases found in other animals. Two examples of these distinctive compounds are: 15-methylhexadecasphinganine and 15-methylhexadecasphing-4-enine.
Sequence:
MKPVAISLSLLLLVTLLPGSEQRKVDNPDFQPNCLVGGPDIYDPAQSEKVLWFDVNLDLPPRQRFQQIAKAYKKEIHAVFDVLNYFLTIIPGVNAWELIGNMTASALDKGMIMNPYRDEVLGIAEVLDVPLGNLVFLNLFYEMSRFCTSIVAQTEDNKDLYHARNLDFGQLFVWDIAAQSWGLTEALKKVSVNINFFKNGKLLFKGSTLAGHVGVLTAMKPHKFSLSMNAKVQPDIINVAKWYMGAYENTDLQFVMYFDRWLFENCDDFQCAREKIAGVKLLTGAYFILGGANPGEGSVLVRNTTSVQFERKLFDGANDWFLLQTNYDPDKDPLFIDNRRDPGNACMNKLTRANVGMKGIFTVLSSKPNLNKTTVHTVIMSVTKGYFETFIQKCPNPCWAF
The following text describes a protein:
Function:
Involved in the biosynthesis of the peptidolactone antibiotic etamycin (viridogrisein). Catalyzes the hydroxylation of free L-proline at the C-4 position to yield trans-4-hydroxy-L-proline.
Sequence:
MSVSAPLLDAKVRYGRDGWLPLPHTLSDPDVRKLRQRIEGISREQRPEVVLEEGSSAVRALHGCHDFDEVCARLVRLPALVGLAEQLLGGPVYVYQFKVNMKQAHEGAAWPWHQDFAFWHHEDGMGAPDAVNIAIFLDDVTDENGPLEVIPGSQHAGIVEDTARPGRERSHDWRHHVSAKLEYVVPDEIAGRLAGTFGVRRLTGPAGTAVAFHPSIIHSSSNNTSAQRRCVLLITYNRVTNTPAHPVRPPFLVSRDSTPVVPVDADRL
The following text describes a protein:
Function:
Transfers a methyl group to 7-hydroxyls of the isoflavones daidzein, genistein and 6,7,4'-trihydroxyisoflavone. Can also methylate (+)6a-hydroxymaackiain with lower efficiency.
Sequence:
MESHNSSTLLKAQSHIWNHICNFINSMSLKCVVDLGIPDIIHNYGKPMPLSKLISSLPIHPSKKSCIYRLMQIMTQSGFFYEHDVTENELEIDYILTDESILLLKDHPMSVTPFLQAVLHPILANPWHEMSGWLKTDDPSTFGTTHGMSMWDYACGGVFNGLESLVDVGGGTGTMAKALAKSFPQLECTVFDLPHVVDGLQGGDNLNYVGGDMFKRIPPADAILLKWILHDWNDEECVKILRNCKDAIAKKGKEGKVIIIDMVVEKEKGNSESAKTQLFFDMLMMVLATGKERTKKEWVKLISSAGFNDYKITPVLGLRSVIEIYP
The following text describes a protein:
Function:
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Plays an important role in protecting cells from carbonyl stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNERDTSRTPTPDPAEHNAFFPSPYSLSQYTSAKTDFDGADYPTPYKGGKKVLMIGTDERYILMQNASMFSTGNHPVEMLLPMYHLDKAGFEFDVATLSGNPVKLEMWAMPGEDEAVKSIYAKYLPKLKAPRKLADLLEQAVADDSPYAAVFVPGGHGVLAGIPHSREVKRLLNAFLAKDRYIITLCHGPACLLAPAVEEKPEDYPFKGYEICVFPDALDTGANLEIGYMPGPLPWLVGENLQKLGVKILNKGITGQVHRDRKLLTGDSPLASNNLGKLAAKTLLEAFAR
The following text describes a protein:
Function:
Involved in resistance to oxidative stress. Influences responses to reactive oxygen species (ROS) production. Regulates plastoglobules formation in thylakoids. Together with OSA1, regulates iron distribution within the chloroplast and mediates the oxidative stress response. Together with ABC1K8, influences chloroplast lipid synthesis/accumulation and modulates chloroplast membrane composition in response to stress.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Plastid, chloroplast, plastoglobule.
Sequence:
MAALLASQSCCYGGETARVTKAIGFSSSLENHFTGEATQCYGSKSKRFRIEMRQSELPSKVGINGRSVKMVPASEVVKRKDGVNGSAGKGVNGASLVSSRNINGAASTLVKAPKKTTESYLPPPVEGVRVLPSDEGFSWADENYSSLQRSIDVWSFVISLRIRILFDNSKWAYVGGFTEEKQKSRRRETASWLRESVLQLGPTFIKLGQLSSTRSDLFPREFVDELSKLQDRVPAFSPEKAKRFIEAELGAPISVMYKEFEEQPIAAASLGQVHRAVLHNGEKVVVKVQRPGLKKLFDIDLRNLKLIAEYFQKSESFGTNDWVGIYEECALILYQEIDYINEAKNADRFRRDFRNINWVRVPLVYWDYSAMKVLTLEYVPGVKINNLDALAARGFNRSRIASRAIEAYLIQILKTGFFHADPHPGNLAIDVDESIIYYDFGMMGEIKTFTRKRLLDLFYSVYEKDAKKVMQNLIDLEALQPTGDLSSVRRSVQFFLDNLLSQSPDQQQTLAAIGEDLFAISQDQPFRFPSTFTFVIRAFSTLEGIGYILDPEFSFVKVAAPYAQELLDLKQRQRSGTQLVQEIRKQADDARSSTLSMPYRVQRIEEFVKELDSGDLKLRVRVLESERAARKATILQMATMYTVLGGTLLNIGVTFSNQGSQLVANGSFIGAGIFMLLVLRSMQRVNKLDKFEKMI
The following text describes a protein:
Function:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MIWVLWLFVLVAIALVALAFYYRSQRKNVVTFFHPNCLDCGGGEKVLWVAVDALKEHLPEMHLFAQDATNDSAQEKVNKVFKINIPSNIKFVNVGSADFIKPGYYKHFTLIFQAIGSLVYAFKCLNKEVPAIVIDTTGAPFASIVWKLFGGCKVILYIHYPFISTDMLKAVSSGNDQYNNNQKIAKSKVLTSIKIIYYRIIAFIYSLCGYFADVITVNSTWTGNHIREIFRRDPIILFPPCDTTDLSKLPIENRIPEQIISVQQFRPEKNLPLQLEIIRRLKDTHPNMKLYIIGGCRNEADKKLLDGLQEEIDRDKLPITLVPNCDFDILRNEYFARSSVGLHTMYNEHFGICAVEYLAAGLIPLCNKSAGPLYDIVKDENYLALTADEYAAKLEVAFKCDDSARLQFRNSCSRFSYEEFSKQFIAAVAPLIKSEVTNYKE
The following text describes a protein:
Function:
Catalyzes the oxidation of aldehydes to the corresponding carboxylate by coupling the reaction to the reduction of dioxygen to hydrogen peroxide. Substrates include glyoxal and other aldehydes (Probable). Does not have enzymatic activity on D-galactose.
Subcellular Localization:
Cytoplasm. Note=Localized around nucleus.
Sequence:
MASSIKTVILFLLPLLLAYSVLAAPDITDGGDKPGPEIDDGGGDKPVPGNNDGASDYAKPAFEPEFMGAWVIDNPNAGVAAMQLQLMPNDQIVWFDTTSLGASGYKLPEGTPCPINPDANNQPDCYAHGIAYDWKTSKYRPLTLQGDAWCSSGNLWPNGNLMATGGTFSGDKAIRVIANDDPKGDFTTKIGALADTRWYSSNQVLPDGSSVVLGGRDSYSYEIVPPQMEFKPKRFDLPFMQQTTEPPLGPGRPVENNLYPFLFLLPDGNIFLFANNRAITFEPATGKTVKEFPVLPGGSRNYPPSGSAALFPLKLTADNAPVIPEIVICGGNQPNAYELVDARHVTEKQFLPALQDCNRIQPMAADAAWIPEQNMPSPRTMGDLIHLANGDMLMLNGAKKGTSGWEDATEANLTPVLYTPYKPMGQRFKELTPTTIARMYHSCSALLPDTRVLVAGSNMHQFYTFDTEFPTELRVEKFSPPYLDPALETERTQIDPANTDAVLKYGKPFKITAALMEKQPLVLGEVKVTLLYPPFTTHGFSQNQRMIVPAITSVQNGVITAVAPPSGQIAPPGYYIMFVSHLGIPGAGIWVHID
The following text describes a protein:
Function:
Cell division protein whose function is related to the generation of a transient cell wall structure. Function is linked to the late stages of cell division.
Miscellaneous:
MISCELLANEOUS: Overproduction causes cells to filament, most likely by disrupting FtsZ ring assembly.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Localizes to the septal ring prior to the onset of constriction and remains at the midcell throughout cytokinesis. Recruitment to the septal ring requires FtsZ, but not downstream division proteins.
Domain:
The OapA domain binds peptidoglycan.
Sequence:
MPGRFELKPTLEKVWHAPDNFRFMDPLPPMHRRGIIIAAIVLVVGFLLPSDDTPNAPVVTREAQLDIQSQSQPPTEEQLRAQLVTPQNDPDQVAPVAPEPIQEGQPEEQPQTTQTQPFQPDSGIDNQWRSYRVEPGKTMAQLFRDHGLPATDVYAMAQVEGAGKPLSNLQNGQMVKIRQNASGVVTGLTIDTGNNQQVLFTRQPDGSFIRAR
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MINILFVAGGTGGHVIPALNMADYISERAPHWKISFIGRKNSFEEKLIAGKYDFYGLDIIKSSDIKKLSYYLSIKDALKILGELEPDILVVFGSYITVPIIVASIIKKLPFFLHEQNVIPGRVTKLFYRFSQGVAVSFPETREYFKDKDKIYLTGNFVRTELLTMDKASCKKELGFDENRKLLLITGGSQGSMKINYEVKKIIPYLLNNGWQILHQIGEKNYVSYIEGIPIEEWAKEGYNPVPFIKNMELAICGADFAISRAGATTIAQFLIAGLPAIYIPYPYAKDNHQIYNAEVVVKVGGGELLLENQLNSEKLITLLDKWDNKDRLAKASEACRKISIANGRENFWNLILEKLEGRN
The following text describes a protein:
Function:
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIKKNNNSNNNNNNPIIIKDGTNCFFKEIKDVLKFSRNWNLIILVSTIKLLLIPSYLSTDFEVHRNWLAITSSLPISKWYFENTSEWTLDYPPFFGWFEYFLSKFAYYIDSEMLVIDNLGYKSTSTILFQRFSVIISDSLFILSTLLLSNYIYNIIIKKNNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLHWYHDKSFIISSIIILNPGLLMVDHIHFQYNGFLKGILILSIYFLVRGNILIGSILFSVLLNFKHIYMYMAPAFFVYLLKYYCLKSNLNDNTTSKVNHSKQQQQQEFTIFGIKIFNLIKLGISVLSIFLISLGPFFYMGQIQQLISRLFPFGRGLSHAYWAPNFWSIYNFLDRVLLFNGLYKKIPFFKNFIIPDQVTGNLTSGLVGSETQSHILLPKITPQITLLITILFLIPSIYSILKSKSWKHFILGICQSSFTFFMFGWHVHEKAIIMITIPMGFLCLVNNKFSKLYFLLSTIGHYSLFPLLFQVEEIPTRILILVTYTLLVYLSFISSSSNNNNNNNNNNNNSNNNNSKQRKCSFSLGLYWFEKFYLFGIILLEIFNVFIHPVFLAHIERFSFISLMITSVYTSVGIIYCYLFTFKLIFKNEY
The following text describes a protein:
Function:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAARALSLTVEAFGAPIPRRQGRLLAAFPRLLTRWETTSSIPEAGEGQIRLTDSCVQRLLEITEGSEFLRLQVEGGGCSGFQYKFSLDTVINPDDRVFEQGGARVVVDSDNLAYVKGAQVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSIKI
The following text describes a protein:
Function:
Probable protein acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA) and epsilon-lysine acetylation (KA).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVTRMATKVSLEGKRVVLVPYMAEHVPKYHQWMQDSALLEATGSEPLSLEQEYEMQLSWTQDPNKRTFIVLDKDFVKGDLAHGQPHVEAMTGDVNIYMNDVDDPKVAEVEIMIAEPRSRGKGLGKESVLIMMAYGVKNLEIHKFTAKIGESNTASLSLFRKLGFEESSYSGIFKEVTLEYPVTNLRREELLKLLDEVIRHTHSSNNPSDSLLSGEATA
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (By similarity). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (By similarity). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MKRYSIAPTSSRRKSAIDATLPESNLPARQILEQLDQDTTFVLQEIDKNISRANTVINDKIKPMIQEYAFQSWKVWENTGFWKHFFEQSANVELDSYVEPINEVNPQNNFLLLNEIEKNKQKGRYEDSRGSNKVNQANNDENNDIDNDEKEEPEIAFKKPNLRRLVADGNTPTWSTEHTKPSMKSIQLSPPKRMQTTNFTGGLARENTKLTDSITLEPPALSAETRAVTSSPHSRHYQNQHQRLQSRDSPIKIHTIRQSLDTYHRVSISPKKLKTPIRSTRTSRIESILNSSPILPEPPVLQSEIGSETPKYMSSSSPMKKQQQQQRESLNFQSDNDQQQGLQRFPNTPKYSRLSGSSVNSLLSNKSNLSDDEDDHINPPPQLDSDNHGVVIDNSDTNNNNGDSSDDLAALPVPELNTIDFKDKNSNNNNKRSIQSTPRSSEKKRRSINTKNTNNNNTSAAATAVVVDDDDDRENVFLDHSYKKTPDNQQSNNSTRFFSTGGSNNDNHTETQDNSKSFSQIYDEAISKIRGKKTTSQSNDQNGDEDGDVVMSLDMTVTKDLTGEPTKDLSKDLTENSTTDLGPFRERWKKLTRK
The following text describes a protein:
Function:
Probable transcription factor that is required for cell differentiation. Essential for proper separation of the sister chromatids during early nuclear division cycles in the syncytial pre-blastoderm embryo.
Miscellaneous:
MISCELLANEOUS: Named 'luna' based upon mutant embryo phenotype in which large vacuoles formed in the egg yolk resemble the lunar surface.
Subcellular Localization:
Nucleus.
Sequence:
MDILPSGNIFSELERICTTGYYSSQPSIEDQWQQTCYELERYLRDEPKLQKKMHSNLDNPWDIFSTPARLLEELKIKEQHLDTISTTSSVSSNCSGTSWDSNGSQALSCSVLVKQERIDEEDDDVGCDDKLSVLLAAPPSAISPNPSIGSAGNMTPTSISNSSSISSSNSHSNSNGNTTGSSNIIASPLSSLGSGSTITVSSRNSSAPGIKVRVVQAKNHPGSNARMHLGHVQDFVLPTLTPPSSPESNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNSTPATAILRFTSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNSSNSSSSSHSSSSSISGSSDQPTHSNIPRSTIVRLTTANGKPGAAGISLARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSANGSSKPHHPRQHHSDHSPDAKRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNNVLKERIGFTLQLLHFWLLLGIYLAALLGNGLISTAVACDHRLHTPMYFFLLNLALLDLGCISTTLPKAMANALWDTRAISYAGCVAQVFFLLFLLSAETFLLTIMSYDRYVAICKPLHYGTLMNSRACATMAAAAWGTGVLYSLMHTANTFSIPLCQGNAVDQFFCEVAQVLKLSCSESDYLSEAGIIDFSLSLIFGCFVFIVVSYVQIFRAVLRMPSEQGRHKAFSTCLPHMSVVSLFVSTLMFPPSISSPFLDLVVSFPYTVVPPAVNPLIYSMRNQELKGALRKIFQHALFHHQKDVHHVLRTTENLGKA
The following text describes a protein:
Function:
Involved in non-homologous end joining (NHEJ) DNA double strand break repair.
Subcellular Localization:
Nucleus.
Sequence:
MSGTNSWLNNNNNNSNTTLTNTNTIGGTNFGINQFDGDDWDNIFDGNNGDGDGDLDGDSYKSYQNPYSYRDCIIFLIDASKAMFEPNENNEIPFHNAVKCLIQTITDKIITSDSDLIGVCFYNTNKKKNINDFENIYVLSDLDIPDPKIILTLEEMLENSNFTTNGLGNCQGEMPFCDALWTCSTMFSNIKQSGSSSGENSNNNNFKRIFLFTNEDNPNAYNDSIRNSSIQRSKDLSDLNIQIELFSMNKSVNDKFDFSLFYQHILIFADEENYLDPTQFDASSKFSDLRFKLKRKEFKKRSLGKLPLYIGNLNNNNNNSNSLDSQVIISTQLYNLFSHAHKSSPTLLDPKTNLPVKQLIKNVCANTQATLLPSQIKLCYHYGGEPVIFTKDEMQTIKSIDRIGFTLLGFKPLENIKPYHSIKHSQFIFPDDQSIKGSVLAFNALVEQMLKSGKAAICRFTPRSSSSPRMVALIPQEEILQSESEFNNQQLLNSLSSQQQQQQSSQQSSSSQQQQQQQQQQQQQQQQQQQQQLPSSSQQSNNNRKIQIRPRGMHVIYLPFADDIRYPNNIGVKSDGLEIKQENIDKAKNIIKMMKIKFDEKKFVNPGLQKHYASLQAIALERDKVEETVDNIQPDRKLIEKVIDTTQDFSDGIFPVGYASTVSSATSSTSSSSAKRLRDGKDLSTMDWPDMVKSGEIIKLTVDDLKSFLSNQNIKPSSKAKKADLIDLISNLISGGNFKPDKLHLLKKDSPPLSDNTITTNGGDDDDNNRPSKKVKSTSTSTTASKNTSSSSPPLVSAATMNKKAPPKKSFSVKDKNSSNNSSGGSSKANVNDEFDIDFKNSDQDDDTDNESDVNNKATTSTTTITTTTAAPKKNNFVNNGMFDTRELCKYGKNCYRTNKQHLDEYRHQ
The following text describes a protein:
Function:
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNNNKSTTELVMDYDNDTWPKDPLHLFPASLLTGITVTCVLLFVIGILGNMMTMLVVSKFRDMRTTTNLYLSSMAFSDLLIFLCMPLDLFRLWQYRPWNFGNLLCKLFQFVSESCTYATILNITALSVERYFAVCFPLWAKVVITKGKVKLVILVLWAVSFVSAGPIFVLVGVEHENGTNPLETNECRTTEYAIQSGLLTIMVWTSSIFFFLPVFCLTVLYSLIVRKLWRRKRKDIGPKTSIRDKYNRQTVKMLAVVVFAFILCWLPFHIGRYLFSKSFEAGSLEIVVISQYCNLVSFVLFYLSAAINPILYNIMSKKYRKAAYRLFGIKVPRRKRLLLTKEGGSCAWTESSVTAT