lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Subcellular Localization:
Presynaptic cell membrane; Single-pass type I membrane protein.
Sequence:
MALGSRWQPPPQLPPLLLLLALAAGVRGLEFGGGPGQWARYARWAGAASTGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGAAADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGAGVGSHSSTQRADYFAMELLDGYLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGESEVLDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGICREGWNRFVCDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPTAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMRLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHTRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSAPGFPRLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
The following text describes a protein:
Function:
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus.
Sequence:
MREITIAKECEWRFEVDEPEIEIKLLSGTAECFGTELAVGPPYKFRYQKAAIFTWHGCVLQLDGEPLVEYIAEETPMLTYLNLHFALNGLRKQAEFSSATPDSEASLGPRVCIVGPKDAGKTSLLKTLEAYALKQFYHPICVNLSPTQSMLALPGSFSAFHLATMLDIQDADGFGSSMATGPTQIQAKSPLVYSYGLDEALDNPKLYKNCVSRLAITVASRMSQNDDARRSGLLIDTPGMVDSEKGYNILHSILTDFRVNVCLVLGSERLYSAIKRKYNDAHWLKVLKIPKSGGCVDRSSEWIQHWQAACVKQYFYGDYRMPLSPLSIVLDAQEVVVYRVLEASAHLMRSSVLPLGMGGDGEEDGTSAAAVENGDSGDGLGGHFMQDNHLERIHTDSMTILQNSILAVSSVSADEDEHLILDSCILGYVFVSDVDDTKNRLTVLSPVQHRFPNNALLMGTLKWQDS
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. Also catalyzes pseudouridylation of mRNAs with the consensus sequence 5'-GGUUCRA-3'.
Subcellular Localization:
Nucleus. Mitochondrion.
Sequence:
MTVTNTYNPTLFFTRVVFQRITKFTAKANEENEILFYALFVADLCLDMKGGLIAINKPSGRTSAQCLNELKKIISNSELAQYFRPAPPHPNDRNRRRRKSNRLPDIKIGHGGTLDPLASGVLVVGLGTGTKQLSSLLSCMKTYRATALFGCSTDTYDSAGKIIKIAVHIPTKEEILSGLDAFRGDISQLPPLYSALHIQGKRLYEYAREGIPLPESIKARSMHCEELILKDFIPKEEHTYTDPDEFASKEAIESEELLRPIEGGAERHDLLAKTEQDINPQDGDEKINAKSPTTNSVTDVAKDQTVTNPKKRKFEVTDLARGSRPAIGPIAVLDMTVSSGFYVRSLIHDLGRQVNSEAHMVDLVRLKQGSFALDDENCFDFSEFSAPGWEEKLAAAFKIDLKGDETS
The following text describes a protein:
Function:
Required for microtubule and spindle assembly. Involved in the proper folding of alpha-tubulin.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MHISTGMVRASISNTLVTLTIEGNNDRYQVILDKNVNAKQFVKTCWRNKKPLIVKEGKIFVDKGFPFDPCRTFLEALYEKYSYSSPLPSSVEFKSGKQVEFCGFEKIQSKQRDLKSLRVIILDNYRIEDIEIEYEYSKILPEVIDLDLSRNLFHEFFPILKLCSQLPSLRNLTLDSNLFSNFISSNTVLLIPHLTQLSVNGCGLNSKDVQWITETFPSLEVLYLEANEIILSKATSFKNLQFLQTLSLANNLNLYSADGYAVDVFQGINNLNLSSTSLADVAELPVHTLHKLTFLDISENNIRDIRSLDHLRTLENLKHLRITLSYFNKPTDIAKLLVIARIPSLVKLNDVNISPNERLDAELYYTSCIRKLVIDNEIKDVEELTKIEPFWEEIWKSHELPSIQFHLEASINDWTSGILKNRITKGIKISSINSGATMLLKLHYNWKLLDIKALISYHFAIPVHTSTFVFASSERDVSFSPKTVRDDQKRLFELPFTCTFIDVYAKESGNV
The following text describes a protein:
Function:
Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MFVRFYKRLDRQYIQSQRRWILSSNKCLLQGNKNATISPLRRAFDDQDHWEESQAQNTSSEQDNKGKNSSYFWSRSKATAPQVAHTGLFQNPYLNSPEGLRKFANKSLTEATALVRNLREDSSQEGLVRYIIRLDQLSDILCRVIDLCEFLRAAHPDEQFVAAAQECHEQMFEIMNILNTDVVLCKRLKQVLSDENISSKLSSEEIRVGHILLEDFEKAGAYASPEVRKQFIQLSQNISIIGQDFINNTESLSSSYIKIPCKDLESSGTSHLVLRQLTKDTMGNNYKIPTSGYAPYTLLNACPSEAIRRQVWTAMFSCSEKQVKRLKSLLQLRRKLANIMGATDYVSYQLEGKMAKSPENVKNFLNTLVDHTKPLAAGELEELAKLKRNVENLSETNTLKLMRPWDRDYYSSLSPNFTRPNHRVDGFTSINTYFSLGVVMQGISDLFRDIYGISLKPVVAQAGETWAPDVRKLQVISETEGIIGLIYCDLLERPGKTTSPSHFTVCCSRQIYPEENDFSTIQVGENPDGSRFQMPVISLICNFRATRHGKNKSLCLLELSDVETLFHEMGHALHSMLGRTQLQNLSGTRCVTDFVELPSILMEHFAKDRRVLLRISSNYATGEPIPEELLSAFQEQNNFLKNTETFSQIKMSMLDQRLHSITDQDDIIAVYHGLEREMEVLVDDQTNWCGRFGHLFGYGASYYSYLMDRAIAAKIWDHLFKKDPFSRSSGEKFKEGVLKWGGSRDAWQCIADALDEPRLVKGDDWAMRFIGEVEDM
The following text describes a protein:
Function:
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor (By similarity).
Subcellular Localization:
Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity).
Sequence:
MVMAHFVENFWGEKNNGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQAIQNITQALQKSKENYNAKCVEQERLKKEGATPREIEKAAVKSKKATDTYKLYVEKYALTKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNMANTTIESLIQKFAESKGTGKERPGLIEFEECDPASAVEGIKPRKRKTFALPGIIKKEKDAESVECPDADSLNIPDVDEEGFSIKPEANQNDTKENHFYSSSDSDSEDEEPKRYRIEIKPVHPNNVHHTMASLDELKVSIGNITLSPAVSRHSPVQMNRNSSNEELTKSKPSSLPTEKGTNDLLAWDPLFGSSLESSSAPLTSSSSARPTTPLSLGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPITSNTSPPPTAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAIALTESVNAYFKGADPTKCIVKITGDVTISFPSGIIKVFTSNPSPAVLCFRVKNISRLEQILPNSQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSGISEKSDSGGSGSLRAKFDLSEGPSKPATLAVQFLSEGNTLSGVDIELVGTGYRLSLVKKRFATGRYLADC
The following text describes a protein:
Function:
Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MEVESPPTTTSLIQAGEYLIVQKIDGEQSRIVRFTPKQKILIEKLKFTSDSAFGKPHGLFEVSNNQCFPMSVDRLIEELQLQEAPVATTLADSEVVLSEIVESSDLRVVIAPSALKLEPEQKRQKLEMDAVLEMKKQGVSGQEVVAKLVEGSASFQTRTVFSQSKYIKRKAKKHSDRYIFLLNLATQISYRVLILRPTIRLLAKAYYLKDPDRLAMLRADQLALILQMAGVHHGKNVLVFEQTLGLITSAVMERLGGKGACVHFHRGAVAQSIPCVHSMNYNESTLSTFLPVRIKCLLTGKQLPYENNRKACNEEEENDDKTKEGKCEENVEDQDLEALARRNDRLDRERRGLEMTFEGNAHALIIGSRTVDPINVLELVYPTLAPSASIVIYSPHQNTLISCYDWLSKRQAINLVLTDQMCRVMQVLPDRTHPLMAQHVAGGHVLSGIKVVDQ
The following text describes a protein:
Function:
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
Subcellular Localization:
Lysosome membrane.
Sequence:
MESSRGRPGPETDLLAVAEHQALVFGGGPGRTSSEPPAGLRVSGEEETENVGGANRHPRTSPKTSSCGVVHRPEREALENEPGPQGTLSGAGSRRGAPGAEHEPSLSSRHKNPAPPEGKPSSGRDCRRGGPGGGMDVEQQEEEDNDEEAAAGSRAGRSFSSRLQDSRSLDGLSEACGGAGSSGSAESGAGGGRRATISSPLELEGTVSRHGDLTHFVANNLQLKIRLSGAPPPPPSAPARPCPAPAPTPTPAIPPIDPEVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPVQGLARQVRDIRRTLEVLEALCK
The following text describes a protein:
Function:
Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRLPTVLIGRYIPVDSIVHRLDPRAKLLGMIFLISAVLIVPNLLFYLVPGLAIFLLMFLSRTGFKIYLAGLRSLWFFLVFAVLVQFFSSSEGEKIFWMITDRAIWSAVYIMLRLVLIILLAENFSATTPPLLSARAIESIFSTFGARKIGHEIGMVMTIAMRFVPVLALEADRILKAQIARGANFERGKFFDRIRALVVIIVPLLISALRKAEELAVAMEARLYTGEPPKTRFKDIKWKPMDTLYVLLTAGVLVLVLFGRYFVDGVFQYGS
The following text describes a protein:
Function:
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate. Utilizes NADH but not NADPH as coenzyme.
Sequence:
MKVNISIFGFGTVGRALAEIIAEKSRIFGVELNVISITDRSGTIWGDFDLLEAKEVKESTGKLSNIGDYEVYNFSPQELVEEVKPNILVDVSSWDEAHEMYKVALGEGISVVTSNKPPIANYYDELMNLAKENNAGIFFESTVMAGTPIIGVLRENLLGENIKRIDAVVNASTTFILTKMSEGKTLDDAIEEAKSLGILEEDPSKDIDGIDAYYKAKILHWVSYGEPPEEEERLGIREVRDARNVRLVAQVSKGKISVKPRKLSSDNPLLVEGVQNAAVIRTNNLGEVILKGPGGGGRVTASGVFTDIIKATLKFPNLR
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEGGGGRSGVVVDIDAAVDDDGGSRTRPWVRVDAETGESEEMELSKQAVMRRMGVPARDLRALDPLLGYTASILARGYAIVCNLEQIRCIISSEEALVMRVQGDQGDDDAAARYADELKRRLAAGRHAAAGMPFELIAFGVALECISSVFKSETADIEIEAYPALDELAKKVSTLNLERARRLKSRLAALTKRVQRIRDEIEQLMDDDDDMADCYLTNKMRMDGSILGLNEGLERTGNNNGLFGRSSSAPLTTTVFPKKKDVLRNQLLKFELLLGSAGFVVGMFGVVPGVFGMDFEGVTLYKVPHAFEETIGITGACSLLMFGCFMWYLKRRLFF
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MTSLGSSSSSAMEYVVRVPKNTNKKYNIMAFNAGDKVNVSTWTQVRLSEEEEAAVCEAHSCRFKGQKKGGVTENASYYIFTQCPDGAFEAFPVQGWYNFTPVAKHRTLTAEEAEEEWSRRNKVVNHFSIMLQRRLKEQEGEDGEEEEDREKGGKKKKKPGKGGDLRIHDLEDELEMSSEDKKKKKKRGSDSEAGEDSDDGDFEGQEVDYMSDESSSEEEEPEKVKPSKGEDVPKGIDEMSESSEESEEEKPNEEEKKEEEEEDGKKTPVQQEKRRRKDSSDESESSEDSDIDGDMPSALFMTVRRTPPKRAGGRSSGGSSRAGSRPGTPSLDSASTSNTLKAAASKLEQGKRSETPAAKRLKMESSPQSASGKTTPQPPSGKCTPSSSDVQLTEEAVRRYLIRKPMTTKDLLKKFQTKRTGLSSEQTVNVLAQILKRLNPERKSIGDKMHFYLTE
The following text describes a protein:
Function:
Cytochrome P450 hydroxylase catalyzing the conversion of decanoate (capric acid) and dodecanoate (lauric acid) to their corresponding omega-hydroxy metabolites, 10-hydroxydecanoate and 12-hydroxydodecanoate, respectively; these hydroxylated components affect plant growth, including reducing root elongation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDYVNILLGLFFTWFLVNGLMSLRRRKISKKLPPGPFPLPIIGNLHLLGNHPHKSLAQLAKIHGPIMNLKLGQLITVVISSSVVAREVLQKQDLTFSNRFVPDVVHVRNHSDFSFVWLPVNSRWRTLRKIMNSSIFSGNKLDGNQHLRSKKVQELIDYCQKCAKNGEAVDIGRATFGTTLNLLSNTIFSKDLTNPFSDSAKEFKELVWNIMVEAWKTQFGGLLSFPLRKFDPQGIKRRMTNYFTKFLGLISGLIDERLKERNLRDNANIDVLDALLNISKRTQKRLTGIKSSSCLVSLFPTPFLPFIIICPFLYLLIFHRCKVSDLNGEGSYVGGRVQLNHTPLQIGCDRLTVSNKPRNYGDSYSSFRTCLQGLILHLNTLEWANGRTTSRIHTLLAKKHKKTISQHICTSKKIKIKKLLEHFLSFGAIVKKNLPIPPGGFSSSLFHVKWRKTLSCLGYIIPKDSQVLVSVWAIGRNSDLWENPLVFKPERFWESEIDIRGRDFELIPFGAGRRICPGLPLAIRMIPVALGSLLNSFNWKLYGGIAPKDLDMEEKFGITLAKAQPLLAIPTPL
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MLNNKKENTDEQAGMTVRQRLRQKRELEEKRKFGLAPLCVDAVSGQEISPNVPHLISQAPWYYGSTGPTLEHQRQKNVEAIEALNDQRDAVKVFDKPKTYVAGACGNCGSVTHKTHECYKPRKKVGAMYSGKVTGVSMSVECVEKNYAQKRDRYAMGIGVDLLQSMNQDGGVADQEDQGGHNDGSGGEKRSKLEDVFASKTAVSGGGGGVAIKELPKHLHNLDDDGLFFDPKTGSMRGNPNAADPTKIFQGDLQRYRSGDYYTYLEMQLRFLKGESSSFVDFRLDEQLQKEKQQQTIGSSGGNPSGGGESVGETAHDRLVRSLYGDSTLVSSGNAQKMREALAAASAYTSCSAPDEDTLATSAPSSSHALGPATRNGHLYVYGSYFDTKEFRWGYKCCKRLGREAEACKMEKASTTKELE
The following text describes a protein:
Function:
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKERSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDVTADLQGIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIILRGDNPKLLLKDMKSKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGYVSVPFPETYETTKSY
The following text describes a protein:
Function:
Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
Subcellular Localization:
Nucleus. Note=Nuclear localization depends on PAF1 complex components ctr-9, leo-1 and cdc-73.
Sequence:
MPQESSDAKRIEPPRKVDFMLKPRFTNTVPDVPFDAKFMTCPFVPLGRFVEFQPAAIYRDYKHAVICDDDMGLNVDLIDLKKYDEDPIETEIDEKDNILLEDDGAAKLIAKRSQQHSKLVPWMRKTEYISTEFNRFGVTADRQETKLGYNLKKNQQVEDMYRDKQSQIDAINKTFEDVRKPVKEHYSKKGVKAVEESFVFPDFDHWKHLFAHVQFDGDTITTEFEEEDERQQARESSVIKAMEFEDQKFAAVFVPTIGCLTSFMDDLELERPFDEDMKYEFLLSREYTFKMEHLPPRDRDVFIMYHRNNVFQYNEVDCNVKMTRKPKMALSRKSKLTLTYRNPSELEQKDMNKREAELYEQPKTRKQEILEKIQEKKEEGGDSSDQSSDSDDDKPQKSRSDSSSDVSSDDDSPRKKEPTVDSDSD
The following text describes a protein:
Function:
Acts as a transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MADHLMLAEGYCLLQVPHAPRTLQPYPGPGLDSGLRPRGAPLGPPPPSGTLAYGSFGSPVSFQPFPVSQPPGAGNAHLQSAATPSPGRMPAPPSAAGGPSPLQPAPGAASPLPLPPPPPLPPALGCMDAELIDEEALTSLELELGLHRVRELPELFLGQSEFDCFSDLGSVPAAGSVSC
The following text describes a protein:
Function:
Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants (By similarity). Required for the regulation of starch grain size in endosperm.
Subcellular Localization:
Plastid, amyloplast membrane. Note=Localizes to the amyloplast membrane surrounding starch grains in endosperm, pollen, and pericarp.
Sequence:
MRRSGNGGAAKKKKKRSASAASERRPRADGGMRIVVPLQGVVQGRGGLVLGSLIPCALFYFFQLYIKRNRASPPPPPGSPTAASAAAVSPIHRSLSRGLLAPRAALPAISARGASVRDDDSLYYAGLRRCAADPYHPVTNPSGIIQLGLAENYLSLDLVGRWMEEHAAEAASMAGGEDEDERELSIRGLAAYQPYDGILALKMALAGFMRQIMQGSVSFEPSQVVITSGATPAMEILSFCLADPGNAFLVPSPYYPGWDRDIKWRTGIELIPVPCRSTDNFNISITALEIAYNQAKKRGIKVRGVLISNPNNPTGSFVPKQTLHDLLEFAAEKNIHLISDEVFAGSTYGSGKFVSVAEVVDDLEDFDKGRVHIIYGLSKDLSLAGFRVGVIYSYNESIVTAAAKIARFSSVSTPTQRLLVAMLSDQKFISDYLKVNRERLRKMYHLFVDALDQVGIECYKSSGGFYCWADMSKFIRSYSEKGERKLWDRLLEEAKVNVTPGSSCHCIEPGWFRCCFTTLSEHDIPVLVQRLRTITDSHKPNH
The following text describes a protein:
Function:
Probable endoribonuclease involved in the autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes.
Subcellular Localization:
Lysosome.
Sequence:
MKLLLLLCISCIPLAYSHDGEPFDYLMFTTIYPTAVCRADDDSVPESCEIPSGTPQWSIHGLWPNFENGSYPQNCRGTPRHFDENLIKSIEDRLVVVWPNLYPKKTIQSFWKHEYDKHGTCAQSEKLFESELAYFTEVMKVFDSIDVAGGLKSVGPSEKPITSSDLKNALSGVTSGKTFQFHCLRDKKTKQFLLGDIRLCLNKDLTIRDCPTDGKHPNRVSRFERSIGRNRRGPPLPSFQPCPAEFIYLPEMSSISKSSDSTSPSIFGRIWSAIKNIGN
The following text describes a protein:
Function:
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Sequence:
MSKYAGIVLAGGMSSRFGEPKALAIWKETTFVEHIVKVMGNTLQDIVVISHTDIKERVEQFVQVPVIEDIPHYKGNGPLAGIVSGMEYIEADWYAIMPCDAPNVSHEWFTILLEQTNNEYDAVVPIINGRKQPLLAAYHNRVKEKIYALLQEEKRSMGQLLSQCNVKYVSGEDVQANADWFINVNTKEEYVQAQKDLSNE
The following text describes a protein:
Function:
May act during the development and be a negative regulator.
Subcellular Localization:
Cell membrane. Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Golgi apparatus membrane. Nucleus envelope. Note=May also localize to internal membranes.
Sequence:
MKILLYIAIILSFFSLITISSECKIAVLLSGSPNDLGYNYLMNEARVKAESELKLDFSIYYENLEESMEEAEKAFQDALHKGANLIVVGSFVHVGLGLKYAALTKDQDIYWIIRGNKRPNPDLPHVVILNFNSFELHYLLGYFSGLMTKTGIVGFVAPGPDVNTISTDNSFYLGAKYARPNITFLNVYVQSWYNPNVSYSAAKMLIKNGADLIGMSQDDMSCQKAMMDSGLIGIGATGYPTHLLFGGNVGVSYITNWTNLYVKYAQHVLNDDWPDYSSYFTNLSREDSIFIDDYSYKVPIDIQNLVNDEIQRLKNTSYIPYRSDPYLAQLGIPFDSKGLLVEDQFRANKKLLKGDSISKVIDFGQYSIPIEFIDYPNSLKYGVTIVSGVCIFICLVCMTLVVVFKKARVIKSSSPAFLLLILLGCCIIFAACILFAQSPTNQTCSARIWLLSLGYTLFLGNLLVKNWRIWLLFDNPKLKKRAITNWKLYPWVFAILAIDVMILAIWQGLGNINAESRIGYDSLTQYQYKNVCSSDDQGSIALYLLLVFHGLVLLVACFISFKIKVVDIEEFNESKPITTSVYIITFCLFIVIPLMVSPQSLTSQTTIICVCAIVTTLISMLLLFGSKFYKMATQGLAINETFATSTKSSSKSSKSSYGKDNPNPNAINFGEDDTSDETSEEKHKSPKQKSVNFSNKSNSHLAVFTSDEETSKTSKLSIDFENSSKDISIDQLQQQKQQPINTNGDLENKSNDKIDDDNDNSSVLSKRISNQQNGETEIDSNNV
The following text describes a protein:
Function:
Endoglucanase (EG) that cleaves the internal beta-1,4-glucosidic bonds in cellulose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with EGs, which cut internal glycosidic linkages to reduce the polymerization degree of the substrate and creates new chain ends for exocellobiohydrolases (CBHs). The CBH release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units.
Sequence:
MKTAIFTAVAGSVLVAAAPAPVSPRASKVQYAGVNLAGFDFGCLTDGSCALTGTNKPYNIVGQGSAIGQMQHFVKDDSLNAFRLPVGWQFLLNNQLGGTLYAPNFQQYDSLVQGCLNSGASLCILDLHNYARWNGGIVGQGGPPNAQLADVWKQLAQKYGSQSKIAFGVMNEPHTVQDVVTAIRGAGAKSNIILLPGQGYTSAETFVSSGSAAALNTVKNPDGTTANLIMDVHKYLDSDNSGTHTECVKNNIDTAFKPLAAWLKQNNRKAMLTETGGGNTQSCQKYLCEELQFLNANADVYLGYTTWAAGGFDSTYELVETPTQSNGKWTDTALVKSCVVGSWKNT
The following text describes a protein:
Function:
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
Sequence:
MTSPRLFVLEDLFKFNNIVMDPLAEVYSLPFLLPKILEHPELVLAADAPDNSLMGFILGTRVEDATESFGDAKTMTWNHGHISALAVAQDYRKLGLGTRLLTTVRDMMDRQKDFYIDLFVREKNTIAIGLYESLGYVKYRWIPKFYADDHGYEMRLPLSSDVDRKSLEGIIIKKIYSFGNKLYYLLMFYIFGIIAIVIGGILVE
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MAETAAAGAPRRRVVVLYGSQTGTAADAAEAVGRRLERYWFETHVQPMDEYDIKNMLQERYMVFVCSTTGQGETPDNMRRTWRFLLQKRLPATALAHLQFACFGLGDSSYAKFNFVAKKLHKRLQTLGAQPFVPLGLADDQHPLAVEGALEPFVQSVLNHLLLVMPLAPGQVPVPLSRLLPPRYTITDTKPAPIWAPLTPDTVPTREQPLSTQFLWNKRVTPQSHFQDVRHVAVDISQQPGLTYRPGDVAYIMPQNRRAVVDELLAWMGVDGDVVLELQQRREDSPLPTRLRGRPRATLREILTHDLDIQAVPFRYFFELLSCFAPAEHEVERLRELLLPQGQDELLDYCHRMRRTSLEVLRDFPSTQGHLPLEYLFDLFSPLQPRAFSIASNPVVHAGRLEFCIAIVNYKTRMTVPRVGVMTSWLAALNSEEQLASTTVAVWVQAGTLRVPPPEQRLICIGPGTGVAPFRSLLLDPLRQAAAKHNVLIFGNRNREADFLFGDEWLAQAREHGLHLLLAFSRDEGKKQYVQHVMAEHEALLWESLQAGASILLAGNANQMPKAVRDAFLDTVRRKGGLDGAAAEAYVAQLEKTGRYQVETWS
The following text describes a protein:
Function:
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head.
Domain:
Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
Sequence:
MGEASPPAPARRHLLVLLLLLSTLVIPSAAAPIHDADAQESSLGLTGLQSLLQGFSRLFLKGNLLRGIDSLFSAPMDFRGLPGNYHKEENQEHQLGNNTLSSHLQIDKMTDNKTGEVLISENVVASIQPAEGSFEGDLKVPRMEEKEALVPIQKATDSFHTELHPRVAFWIIKLPRRRSHQDALEGGHWLSEKRHRLQAIRDGLRKGTHKDVLEEGTESSSHSRLSPRKTHLLYILRPSRQL
The following text describes a protein:
Function:
Probable disease resistance protein.
Domain:
The LRR repeats probably act as specificity determinant of pathogen recognition.
Sequence:
MGSCFSFQIAVGDQTMNRIFDCLIGKSYIRTLEKNLRALQREMEDLRATQHEVQNKVAREESRHQQRLEAVQVWLDRVNSIDIECKDLLSVSPVELQKLCLCGLCTKYVCSSYKYGKKVFLLLEEVKILKSEGNFDEVSQPPPRSEVEERPTQPTIGQEEMLEKAWNRLMEDGVGIMGLHGMGGVGKTTLFKKIHNKFAEIGGTFDIVIWIVVSQGAKLSKLQEDIAEKLHLCDDLWKNKNESDKATDIHRVLKGKRFVLMLDDIWEKVDLEAIGIPYPSEVNKCKVAFTTRSREVCGEMGDHKPMQVNCLEPEDAWELFKNKVGDNTLSSDPVIVGLAREVAQKCRGLPLALNVIGETMASKTMVQEWEYAIDVLTRSAAEFSGMENKILPILKYSYDSLGDEHIKSCFLYCALFPEDGQIYTETLIDKLICEGFIGEDQVIKRARNKGYAMLGTLTRANLLTKVGTELANLLTKVSIYHCVMHDVVREMALWIASDFGKQKENFVVQASAGLHEIPEVKDWGAVRRMSLMRNEIEEITCESKCSELTTLFLQSNQLKNLSGEFIRYMQKLVVLDLSDNRDFNELPEQISGLVSLQYLDLSFTRIEQLPVGLKELKKLTFLDLAYTARLCSISGISRLLSLRVLSLLGSKVHGDASVLKELQQLENLQDLAITLSAELISLDQRLAKVISILGIEGFLQKPFDLSFLASMENLSSLWVKNSYFSEIKCRESETDSSYLHINPKIPCFTNLSRLDIVKCHSMKDLTWILFAPNLVVLFIEDSREVGEIINKEKATNLTSITPFLKLERLILCYLPKLESIYWSPLPFPLLLNIDVEECPKLRKLPLNATSAPKVEEFRILMYPPELEWEDEDTKNRFLPEMVSTSTSSKDPLLRNGIPRCLKSESTLLLLILLYLSSCRAFGLYN
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEAGARLAFVMPLVVVLLLMIFSLGVRGVDVVVDGGGGGAAAARRRRVEVGVILDRRTWLGNISWACMELAVEDFYADEERASYTTALRLHLRDTRLDAVDAASAGVDLLKNVHVQAIVGPQTSAQAKFLAELGEKSSVPVVSFSANSPCRTASQTPYFIRTAWNDSSQAEAIASLVQRFNWRDVIPVIEDDDSNTRFIPDLVDALRNAEIRVTHRCKIHPSAGADDIKKVVLSLKEKWTSVFVVRMSYQLALSFFKHAKDEGMMGQGFVWIAAYGLTDIFDVVGSPAFDVMQGVIGMKPYVNDTKQLQNFRQRWRKMYKSENPGTTLSEPTLSGLYAYDTVWALALAAEKAGYVNSDFLLSEKNNGSTDFDRINTSNAAKKLQSTLLNIDFQGMSGKFQFQDMHLLSMTYEIINIVGEEQRVVGFWTPEFNISRGLNTKADVNEIIWPGGETTVPRGWLFPMNKTLKIGVPAKPGFSGFIKKEKYNFTGLCIEVFEEVLNGLPYKIPHDYVEFGNGKGESNGTYDELIYKVYQNDFDAAVGDITILANRSLYVDFTLPYTESGVRMLVPVQDQRQKTAWTFLQPLTADLWLGTAAFFVLTGFVVWFIEHRTNEDFRGPPVNQIGSVFYFAFSTLVFAHRQKIVNNLSRVLLVIWLFVVLILQRSYTASLSSILTVEQLQPTVTNLDEVIRKGANVGYLNDSFMPELLKRLKIDESKLIALDSPDEYNEALSTGRVAVVVDEIPYLKVFLSKYCHNYTMVGPTYKFDGFGFAFPLGSPLTAEISRGILNFTSSNRMAQLERELYNNRTCPDKDDSQTSSSLTLRSFLGLFIITGASSLLALFLHVVITLYNHRHDLSSASSSQSSWCGWFAILLKIFHEGDRPNAPQLDEPAVSNANTTADTPWSTPDHHIIENVDSGSDVESVREEDREDFVQGPDPPSFAYMHSERGQ