lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MPGPLYRDPWAAREAWRKSPIFSNKAMFRSMFPGLGTAIVAFTAYVIYDDFFAAKSSHGHAHGKEHPKTLAM
The following text describes a protein:
Function:
Involved in the formation of nucleus-vacuole junctions (NVJs) during piecemeal microautophagy of the nucleus (PMN). NVJs are interorganelle interfaces mediated by NVJ1 in the nuclear envelope and VAC8 on the vacuole membrane. Together, NVJ1 and VAC8 form Velcro-like patches through which teardrop-like portions of the nucleus are pinched off into the vacuolar lumen and degraded by the PMN process. Also acts as an outer-nuclear membrane receptor for OSH1 and TSC13.
Miscellaneous:
MISCELLANEOUS: Present with 1900 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus outer membrane; Single-pass membrane protein.
Domain:
The extended 80 Angstroms-longloop of NVJ1 specifically binds the highly conserved innergroove formed by the armadillo repeats of VAC8.
Sequence:
MTRPPLVRGIFSLGLSVAVLKGVEKTVRKHLERQGWIEPQKVDYELIFTIDRLKNLVDNKREALTAEQPDAGELSWRKVFNFISRQSSELDTRIYVLILLLSFLLPIAWTVLDGDRETTLEDKDNDCNVDLIENERRLKHYNDGERAVLQFGKNRSEPIILSYKDMNVLEGEHEFTSKEEHSNSHLTSKSENALNQVGSEDLLGCHLEKQLEEDKNEPNGEADGEDDNNREKDCSSSSEVESQSKCRKESTAEPDSLSRDTRTTSSLKSSTSFPISFKGSIDLKSLNQPSSLLHIQVSPTKSSNLDAQVNTEQAYSQPFRY
The following text describes a protein:
Function:
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Note=Localizes at rDNA locus.
Sequence:
MFEEPEWVEAAPAIVGLGAATAQVRPATAPPVKGRKRRHLLATLRALEAASLSQQTPSLPGSDSEEEEEVGRKKRHLQRPSLASVSKEVGKKRKGKCQKQAPSISDSEGKEIRRKCHRQAPPLGGVSAGEEKGKRKCQEYSSLHLTQPLDSVDQTVHNSRTSTATIDPSKPSPESMSPNSSHTLSRKQWRNRQKNKRRHKNKFRPLQTPEQAPPKASIEETEVPPVPKSDSQESRAGALRARMTQRLDGARFRYLNEQLYSGPSSAARRLFQEDPEAFLLYHRGFQRQVKKWPLHPVDRIAKDLRQKPASLVVADFGCGDCRLASSVRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKTGGLLKVAEVSSRFEDIRTFLGAVTKLGFKIIYKDLTNSHFFLFDFEKTGPPRVGPKAQLSGLKLQPCLYKRR
The following text describes a protein:
Function:
Binds the 5S and 23S rRNAs.
Sequence:
MKIKLVRSVIGRPGNQVKTVQALGLRKIGDSREVSDTPAVRGMVKTVKHLLEVQE
The following text describes a protein:
Function:
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MRMMAVAVVGRKNQLQFLHRVPELDEVTCQQYLFANLDVIEDKNACTAAVIGLIVSKSDSEKRECFLGGMLPQDDMRCVRIALGLVMASALVRRLRAQVHQRTGLPALARSQPCTRRYAAKPQPLQKDLALLEADKVRNFSIIAHIDHGKSTIADRILELTGTISKTGSNKQVGASPPTQMATRLSHNDVIMARPQVLDKLQVERERGITVKAQTATSFYTHEGVEYMLNLIDTPGHVDFSYEVSCSLAACQGTILVVDAAQGVQAQTLANFFLAFEKDLTVIPVLNKIDLPGAEVERCKAQMESLFDIAPEDVILVSGKTGLNIEQILHHVIQRVPPPSADREAPLRALVFDSWYDEYRGVIALVELMDGRMRPGDRLTSAATNLSYEVQELGVMYPEQRPTDGLYAGQVGYVVCNIKDRQEVRVGDTFYQRGKPVQALPGFKPAKAMVFSGLYPVAQIDYEALSAALDRLVLNDPAVSVARDVNAALGPGWRLGFLGILHMEVFSQRLEQEYDIQVLLTSPSVCFRVHTKQGELLEVESPDKFPALADIDFCEEPMVMGTIVHPQEYTGAMLSLCEDHRGVQKIKSASSGYATFDYEEIGYKVSDIVKVQIMLNGDPVDALSIMTHGSRAFSKGKALCQRLKETIPRLVDRPNVGQWIDPHWWAGWGGGGRGTHQLEVLGSHDHNPHIALHDSQLVEIAIQASAKNKIIARETVRPFRKDVTAKCYGGDITRKKKLLSRQKEGKKRMRAINSIQLPKV
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MRNIYPHILLLVSIVFLALDLGESLHPHHFTYKVKGGYGESQNHKHPKEGKNVELGMDLYPTGSSIPDCSHACGPCFPCRRVMISFKCSMPESCPVVYREICSGDIVAEVEYFGI
The following text describes a protein:
Function:
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Sequence:
MSIRLWEGHIEDNGVSFSYTSPDGENGYPGEVSVTINYQLADDNKILISYVAKTTKATPINLTNHSYFNLGGHDSGSVTDHIVEIDADKYTPMVIETRLPSGEISSVDDTVFDLRSPTRIGDKINEVPGLGYDHNFCVKSSEKPCVIVTHKESGRKMEVSTTKPGIQFYTANYLNDSTVGKCGAIYPKHSALCLESQFYPNAVNQVNAESASATIADTVNSLATASPDAPIMVLGDFNHCRLENTLPNYHQVVDCATRGNNVLDRCYCSIRDAYKANVSKSLHELYDLNCLLVEQGNFANGQFGE
The following text describes a protein:
Function:
May be involved in the transport of sterols.
Sequence:
MEAMAHHQQRRRRRSTASKELAHGNRKIYDPRRWHKRTNSGSEIGGQPPAGWVLIWAGRFKRWRRRWFVANPPGLLLHYKNSNQIGRHGCISLLGATVVPTPGKERQFKIMKGSMVYYLRTIRRDYRQPWLDAIHDSLRVFHDSLERAQGGAGGGTSLLPQHSVPSHKREDWEAQEKELKRRVRERLRDLEPTRKAFLDQLQTLQHSLSTISGVLGFADTPEVPQKSTTSALPALPRLPETNWRSNGLFMTEHEALDSDVPQQHNGSPATGDDRISSPEMGASNSRQNHSAPISPRTSQLHDNDPNSRSASRSFLKWKSDPDTLTLTDSTIDLSCIRSQKSVPVFETLIDKKFRGDRRRSLSFSMDDPDCFPQDMSCIGAECFPVRKRGGHGNASDTESSSKKQPVRFSSPLHQRKKNVESVYNFTPNSSQELDPSLMKKLEKDVFVQSKESEALLHGSASKTSGVSSHCSKEVRFGVGQLRAIDNGGSTGPGRNELFSQGPLHAAWNNMQDTYTEALKEEIYRVLELEAENAILQQAMRSLPQLQQDRAALYRLKERNKKQCECGRKNISEEEIEEDGEDTEEEIAIVHPDVGNEEYFEALEVLNHHEFAARSISPDEQGILAETADGNQEPPEEAETGDADFLSEVEGEEIDMPRIRLPAPRPLSRGFTVWTVLKNAVGRDLNHITMPATINEPLSVLQKCAEELQYRHLLEQAVQKENSLERLLLASAFACASYYGSIHRDAKPFNPLLGETYEYQDNRCWFLAEQVSHHPPILAFQSEDIGGGYQIYGEIEIKNKFWGRSIEVLCNGAVHLKIPKYEDHITWNRATLCIHNVLVGKAWIDNYGEVSVINHTTGDVGRIRFHKASSREQCRITGKMYDSKGVAHYTIFGNYMEAVYSCPESCTNFDINGPDVRLLWKAPEQIEDYRQQYCFTRYSLALNELTPKLSYALPPTDSRFRPDQRALEDGDLDKATPEKLRLEDKQRIARRVRKEQGVEWQTMWFTQRDPEVSEVKTIEEGNVEPSWVYKGTYWDAREKLDWENCPDIMDSSATSLLPVIKQAERDTV
The following text describes a protein:
Function:
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MTPHEIDIALGMEKYYYEDWNELDGTIERPNGFKVIEEIDFKPAQDWKGETKGKYAVFLLTKWGIDHFSAISEVQKVLHSKVNYIGIKDANAITSQLVYIPLNEKQELIEKYQSRSFILKFLGFSSKKLNHTGNIFEISLSISDFDIVIERIEQIKKNPYLPAFIGYQRFGTRRPITHLIGKYLLRRDWEKAFYLILTYPFLSESKETIDIRKLIMEGDFKEAVRSIPSKFKQEKLLLKNYMRFNSYYLALKSSFIPISLYLDAYQSYLFNLYLSRKLDEYKNLNDKVNLLIRIPIYFNNCDDVCKEIYLDEGIERNFFKLQEFKISLRDLVRKAFMNIRDLKVNEETKTISFVLERGMYATILLREILRGDPRKFT
The following text describes a protein:
Function:
May act as a transcriptional regulator of dctA.
Miscellaneous:
MISCELLANEOUS: Overexpression causes filamentous biofilm formation.
Sequence:
MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQIERLKPVHVIIFSPFNIKRCLGKVPVTFVPRTITIIDFVALINGSYCSVPEAAVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNLKRINELVRHQHIDYLV
The following text describes a protein:
Function:
In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Subcellular Localization:
Nucleus.
Sequence:
MPDLRLRSSALSRAPPPPPLQAPCSSPVCSYRSVQRRTGAREDNSTGRRQRWHSVLQRAENMVNAIKGLFISCDVPMAQFIVNLNASMPASDKFILHMLDPTHMFVQPHVAEMIRSKISEFRDQNSYEKPT
The following text describes a protein:
Function:
Involved in actin patch polarization. Required for maintaining a proper budding pattern in yeast cells. Required for proper polarized localization of the ADP-ribosylation factor ARF3 at the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Present with 768 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, perinuclear region. Cytoplasm, cell cortex. Note=Enriched at the nuclear envelope and at the plasma membrane, especially in daughter cells and at the bud neck.
Sequence:
MLRRELNNSISNRSIENESFPFERPNVSYIISAEFDNKLGPILKHQYPKDIPGFNQFSHEQRNGNTSVSMNLASLMIPSSIERNPGKQDITVFTLYYNKFTQNYQLFPVPKDPRFSFNLHHREQSDGSVTNSIYYDAENHQDAKNNRYTIVLEDDELECQEVQNNQKAIDNEPLFFINVANTVLDTTNDRGAVIKSIAIGTPLKTFFAFKNIIVLVLDLYMKAPTQAAATDILLDCFNMLNSIDLTLINDIHSKSSIQEVLHSIHDESIITKVFLDPDSTLKKLFCINGFDTKDKYGNIVTFHDQLIQYHFTRFQPKTLPPFLLKIPLQFNMIRREPIYIENDYNELVLKFLDKFVPYLLKAGQKVNAWKLVINSTKLSKEDLCAFILSLANITATYASDPQSYFKGNAALIFPYMDISLVDGLRAYVASNSDFVGCFAIIGTANPIFRYQLDIWDYYYDVDEGVFYENNSPEKEKPDTVAEVKIGPNPLRKIFNRPHFSTNAVNESQVNLGQKLFSLLIDEYHDSDTIMSVLRRLNVLQLENLLDALKRREIPPNIALKDEYIMFYKDFFIFPEFFDYFTLHSIELLSNLDNCLFSLGNTCQLFSTEQIYSQLSQILDIVKELFRMVSVSRTNIEKFLNACLNYSPFKILPTAQLHGDNISRWSFESEVRQGFDNFNSYMGIEKDPHGVIVSAIDLFTQIYSFDILAFFLTFITKESGQDLPFTKSLSRRRTYLTRIAQSSSLRQFLQLSTRPNIRILGGNGQGTGNSNYPEFTNASSVISPKLRASPLLERRASKICYAITKLLYRLECHPIGMALLKKYLHNQLREAYLESKRHFISKKGDSTNTSSTIASSSFAGASVPLSSNESGMLNGLKQINEQQESTLETTQKED
The following text describes a protein:
Function:
Functions as a sphingoid long-chain base phosphate (LCBP) phosphatase. May play a role in the regulation of LCBP levels and be involved in stomatal responses through LCBP-mediated ABA signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKKILERSMEGSGTWQGLVLVGIVTWICASSYLKFTHKFRSLLQPWVARQVVGGVPLILRIQKCQNGVLDAFFSGLSCVVSVPFYTAFLPLLFWSGHGRLARQMTLLIAFCDYLGNCIKDVVSAPRPSCPPVRRITATKDEEDNAMEYGLPSSHTLNTVCLSGYLLHYVLSSLEYESVSIQYYGFALACLLVALIAFGRVYLGMHSVVDIVSGLAIGVLILGLWLTVNEKLDDFITSKQNVSSFWTALSFLLLFAYPTPEHPTPSYEYHTAFNGVTLGIVTGVQQTYSQFHHEAAPRIFSPELPISSYLGRVMVGIPTILLVKFCSKSLAKWTLPMVSNALGIPIRSSMYIPKLKGYASGKKTDEPKNSVGYLQKLCEFLSHDSFDIDTGIRFFQYAGLAWSVVDLVPSLFSYVNL
The following text describes a protein:
Function:
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MPANVRTPLLQSAGPLEPFITTAKHIFGWLAYGSGSGPQGVFSVGFLNPLLLMQNAHKHGVLESDLVTQCSVSPTEPCVVQLFGLSWVNTNSLVFVAGAISTFIQVLAMFTVGAISDYRDNRKKIVVLFTITGVISSLAIAMLPSHLYELHILLFIFADVSNVLCGSIYDSFLPILVRHSHNPDLHYLRRNDAGSILEEASSSSSEGDEECATDEEGPVLLENSVVLDAKHPEEHFHTALSTKLSSWAFCVYFSSTLIFQIVYVFLSYFNYFEKTLLRNGVLITAVWLLLSSIPLALFLKTPVEQTASRSFFSLLFGSWSESFQSLKHAMEIPAVRIFLFSRMFLVCALQTSLSAIVIYSRAYLGMSNFQLLITISSFTLLAIFGTLGFPTLTKSLNLSSLQTVILAAFVLPLAPLYGLIGDLPFTGPQIGFTSIADAYAVTIFLGFMVGGLHTYCRSIFSQLLPKGREARFFSLYAIVSQTGVCIGQVALAILSNVFEQLGPVYIFLTIILLSTLIGLLLLYRHNHFL
The following text describes a protein:
Function:
RNA-binding protein which mediates polarized mRNA (e.g. Ran2 transcripts mRNA) transport from the nucleus to the vicinity of the cell plate during cytokinesis and phragmoplast formation.
Subcellular Localization:
Nucleus. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, phragmoplast. Note=Associates with the forming cell plate during cytokinesis; may shuttle between the nucleus and the forming cell plate.
Sequence:
MVLSNKKLKQRIRQDLAESLSVSVSETNPQSQSLKLLLDSSSHKPRLSKREKRRNCETFAREDDEIRENEVGNGGSSEKTDTKIKKKRKRDDAVEVDELEGDEGTKEEQKPQKKKNKKKKKKRKVNKTPKKAEEGNVEEKVKVEEIEVNTDNKEEDGVVPNKLYVGGIPYQSTEDEIRSYFRSCGVIIKVDCKMRPEDGAFSGIAFITFDTEDGAKRALAFDRAAMGDRYLTIQQYVKTTTPSIPRRKTSSGFAPEMVDGYNRVYIGNLAWDTTERDIRKLFSDCVINSVRLGKNKETGEFKGYAHVDFKDSVSVAIALKLDQQVICGRPVKICCALKDRPATDHTPGETNNAGSYNMEDTYAAADPVPALAGRSEVDDGNYFATTVSSSKVKRRVCYECGEKGHLSTACPIKLQKADDQANSKLGQETVDGRPAMQSYGLPKNSGDSYYMNETYASTNETYNGGYSASAVGTGKVKRRNCYECGEKGHLSTACPIKLQNTSHTNSTLDHQTVEAGPTQVTSYSLQKKTRDTENNGGSFMDESYATVPISIDVTNGANDASLTSAVSTGKIKKRNCYECGEKGHLSSACPNKLQKQG
The following text describes a protein:
Function:
Essential for hematopietic stem cell development through the regulation of p53/TP53 pathway.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAVYSGISLKLKSKTTSWEDKLKLAHFAWISHQCFLPNKEQVLLDWARQSLVAFYKKKLELKEDIVERLWIYIDNILHSRKLQNLLKNGKTINLQISLVKIINERVAEFSLSGSQRNICAVLRCCQGILSTPALAVIYTAKQELMVALLSQLCWSACRQPEGAVVAQLFEVIHLALGHYLLILQQQVNPRRAFGDVTAHLLQPCLVLRHLLSGGTWTQAGQGQLRQVLSRDIRSQIEAMFRGGIFQPELLSSYKEGLLDQQQGDVKTGAMKNLLAPMDTVLNRLVDAGYCAASLHTSVVANSVALLYKLFLDSYFKEGNQLLCFQVLPRLFGCLKISHLQEEQSKALSTSDWTTELLVVEQLLNSVANNNIYNIAADRIRHEEAQFRFYRHVAELLINHAQAPIPAWFRCLKTLISLNHLILEPDLDDLLASAWIDAEVTEFRTKKAQEALIRTVFQTYAKLRQVPRLFEEVLGVICRPAAEALRQPVLASGPSTVLSACLLELPPSQILDTWSLVLEKFQSLVLPYLQSDADMALKSLSLSLLLHCIMFNMRSLDSSTPLPIVRRTQCMMERMMRELVQPLLALLPDTPGPEPELWLQKVSDSVLLLSYTWAQVDAMFSLNCSQYHSMSGPLIGVALEISNLPSLLPGVKTQHWKKIEKFTAQFSSLGTYCLEQLYLQKMKRTLMQTSFRSEGAIQSLRCDAAFIIGSGRKSLNQRTTASWDGQVGMVSGLTYPVAHWHLIVSNLTILISYLCPDDVGYLASVLLRTLPMGKAQEVSIDEEAYITLEKISKAFLHSPLFPEMQSLHSAFLTCVTTSCSSILCSGAQRDSGLVSQQLPWLFEKDHMVVGHWENRFAKAGPEGIEPRGEIAQNLLSLVKSDFPIQLEGEQLESILGLLEVISALQLDSLLPPYHVHYFLVLLSMAVTKLGCSCSSSLALKFLTTCYQLLGYLQKGKSARSVFKIMYGSDIFEVVLTSLFRASSRFLIEMDDPAWLEFLQVIGTFLEELMQMLIQMKLSLVLNFRKITAFLSSSKPYTEAASSKQLENQNPQGRQLLLVSLTRLCHVLGPFLKEQKLGQEAPAALSELLQQVVLQTGAVLQLCSVPGARGWRLPSVLISSVSTLLEADLGQHCRDGGADISQGSDRTLLSHVALYQGVYSQILLELPALAGHDQSFQAALQFLTLFFLAPELHPKKDSVFTSMFHSVRRVLADPEIPVQVTQDIEPHLGALFTQMLEVGTTEDLRLVMQCILQGLDVSNMWKADVQAVVSAVTLLRLLLNCPLSGEKASLLWRACPQIVTALTLLNREASQEQPVSLTVVGPVLDVLAALLRQGEEAIGNPHHVSLAFSILLTVPLDHLKPLEYGSVFPRLHNVLFSILQCHPKVMLKAIPSFLNSFNRLVFSVMREGRQKDKGSIDDLPTVLKCARLVERMYSHIAARAEEFAVFSPFMVAQYVLEVQKVTLYPAVKSLLQEGIYLILDLCIEPDVQFLRASLQPGMRDIFKELYNDYLKYHKAKHEGEKRYTA
The following text describes a protein:
Function:
Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption. Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids. Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo.
Subcellular Localization:
Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen.
Sequence:
MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKYPPVTPSPPCQSKYPPKSK
The following text describes a protein:
Function:
Involved in the transcriptional regulation of the propionate catabolism operon.
Sequence:
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYARSRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQLLPELMVNTAELTPSTVDANALQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSDN
The following text describes a protein:
Function:
Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination. May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (By similarity). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (By similarity). Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair.
Subcellular Localization:
Nucleus. Chromosome. Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation.
Domain:
The N-terminus (residues 1-115) forms a head domain that is structurally related to those of XRCC4, XLF/NHEJ1, and SASS6.
Sequence:
MAPPLLSLPLCILPPGSGSPRLVCYCERDSGGDGDRDDFNLYVTDAAELWSTCFSPDSLARLKARFGLSGAEDIHSRFRAACQQQAVTVSLQEDRALITLSGDTPALAFDLSKVPSPEAAPRLQALTLSLAEHVCNLERRLAAAEETITSPKKNTQPAGTQFLPELDHQRGSSGPGVRRRCPGESLINPGFKSKKPAAGVDFDET
The following text describes a protein:
Function:
Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures.
Subcellular Localization:
Cytoplasm.
Sequence:
MADPDSYRSSITSRPAFNRTVTSSTQNYGTPASGNRVLKIVTETHTSSVASGLSPYGQGAASTIRDDREREKKEITELNDRLASYIGKVRFLAAQNRKLEADLNVLQSRFGKSTGSVKIMYEMEITTATNVVKETGKDHEEAEKEIGKIKDQLDELRKKFEEAQKGRAEDRLKIDELLVTLSNLEAEINLLKRRIALLEEEVARLKKENFRLTSELQRVRSELDQETLLRIDNQNKVTTILEEIDFMKRGFETELKDLQAQAARDTTSENREYFKNELMNSIRDIRAEYDRFMAGNRNDLESWSQIRVQEINTQTNRQNAEINHKRDEVKRLHSQVSELKSKHAELAARNGLLEKQLEDLNYQLEDDQRSYEAALNDKDAQVRKLREECQALLVELQMLLDTKQTLDGELKVYRRMLEGNSEENGLRQLVEKVVRTSAINEEVDTETMRVVKGEHSSRTSYQRSAKGNVSIKEVSPEGKFVILENTHRDKEEPLGDWKLKRKIDGKREIVFTFPSDYILHPVQTVKIFARGNGVANPPEVLVFEGDDTFGAGANVQTILYNNSGEERATHMQRQSQQTTTS
The following text describes a protein:
Function:
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Subcellular Localization:
Cytoplasm.
Sequence:
MAESALTPLRLAQLRRFAARFALSEPEALSWELLHRALIHPSWSAQEGGEDNDRLEFLGDEILRLLAAEFLYRADPELTVGEMTAVRSVLVSDVALAELAEGYDLGEFLVVGRSASGDERGRITRLADGFEAVIGALYLSTGDLGLIRPWLLPHLAHLAESVMADPTRGNHKSALQELTQKLAAGELPEYRLVDPGPPFRYEVWALGRLWGSGEGPSKKLAQQRAARGAYAALRSAFDTALQ
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGMQYYFFTQNTTFQVGVILDADSLVARTGMTSLSLALSDFYSTNSNYSTRLVLHTRDGRGRITDAASSALNLLKDVQVDAIIGPQKSSQAEFVIGLGDAAKVPIISFSATSPSLGSQTEYFVQTALTDAAQVDAVAAIVKYFRWYQIVLVYEDSDYVNARVSYRSVIPTSATNDFMLQELYKMKTMQTRVFVLHTTSSLASRIFLKAKEAEMMSEGYVWIVTTGIMELFYSLDSKVVESMQGVVGVKPLVTRSSKLNFTTIRWKKKFADDYPGITPQEEMNLYGLWAYDTLWALAMAAEKTGFKEPTSLPNKTALNSTDIFITGTSQTGPKLLAAMLDTKFEGLAGNFHLVNEQLEPSSFEILNVNGKGLRQVGIWTPFVQSSSQVYGNSMGFTGEKLENIIWPGESRNVPKGWEVPVSGKKLRVGVPLESGFSEFVKVEKDTQTNSTKISGLYIDLFDSIMAALPYANYDVAVGDITITATRSEYVVFTLPIEEGGVTRTQKIQYDDNRNDKWFFLKPLKMELWLTILALFIFTGVSLWILEHKFNKAFRGRPSGYLGLIFYIPFMSLVFAHREKIVTNLARVVVVVWIFVVLVLTSTCTASLSARLTTFKLQQGDTDVNTLIRNGDYVGCREGTFRTFLVEFLTRLGFHESKIRIYKHAEEFANALSKRSANGGVTAIFSSTPYADLFLSKYYSNYTKFGSPYLTEGFAFGFPKGSPLVGDVSSAITKLTDSHKIAEIKAHWIRQSGCNEDDDPSKVGWTNIGLRSFKVLFAVTGAVTGTTVVLFLVSFLYQNRVRVRNIYNSDNTVGFKVHAFGRLFDERD
The following text describes a protein:
Function:
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Subcellular Localization:
Secreted.
Sequence:
MQIRTRLASVSLSHRSGSWACPPPCSGQPCVGMWEGRLGLLLSPSARNRVGGRGSALGGAGGPGVAWLCLLPVSPLRLEPEPGIPWRTSSFTMALETACHPLGKRRCEMQAFRIWDVNQKIFYLRNNQLVAGYLQGPNTKLEEKIDVVPIEPHTMFLGIHGGKLCLACVKSGDEIKLKLEAVNITDLNQNREQDKRFAFIRFDNGPTTSFESAACPGWFLCTSLEADQPVGLTNMPTEALKVTKFYFQQD
The following text describes a protein:
Function:
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MVNSQRMRMANEKASKNVVLRGNVPKTTKPQDEKYPVGPWLLAFFIFVVCGSAIFQIIQSIRFG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MESNEVNSSFFPPPPPRHKLFTNKNLSLAKRLRAEADDYQEISDEHPFDRSKQQEIVGEELNEVDLRTLIQPPLLDWIRQNNGWNAFGDHEPWPDCSSGRASLEGMPKLYDPKMERKDALQALLNTLIHGYLELLQVLTNEGPTSLSTSTTATNTTTGGTAGTAPTSSKTDQIVSHIELTAFNIHGLCNELRPRQARETLKLMVAQQASEKRQKAILVSQTCEELRKQLVQIKNEHPSSSPADSRANPALPSKPRSPKQPTPIQDQALRSQGATTPRSAGYDFDLLASRLHNPLLPPSSSFS
The following text describes a protein:
Function:
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSNGGNAGKKSSSYFHFTAGLGSGILSAVLLQPADLLKTRLQQSNHASLLTTIRELSQSPNTIRSFWRGTVPSALRTGFGSAIYFTSLNALRQNVARSNLLRTIGVVDAKNGPVHSSSLPKLSNLANLTTGAVARAGAGFVLMPMTIIKVRYESNLYAYKSIMGAGRDIFLTEGFRGFFSGFGATAIRDAPYAGLYVLFYEQLKKRLSHIVHSVPQAEELVENLGVRKNMKGSTSASINFGSGVLAAGLATAITNPFDAIKTRIQLQPKKYTNLVMAGRKMVGEEGVKSLFDGLGLRMGRKAVSSALAWTIYEELIRRAELAWKGEEVIV
The following text describes a protein:
Function:
Has a role in sporulation.
Subcellular Localization:
Cytoplasm.
Sequence:
MIALEKLSEKNKRSTKKCEISIYVGNLPSTCQSSDLHELFEPFGNFSKFHMLSRKKNKSTDSKSPTLFAFITFENKCSADNAIASLNGSSFQGNTLKVEYTHIVERYKNKLENGVDQIHHSNNEKAKIRFSKIEKYTKETRPTVSEVRVSTKDKKEYSMNTSNLVQSNPPKVHDKENAFAEATGTSILSSKAVQTLLVSDFTENEPKHLSIRPNCKDNNTPSISNTFIEPYKENNTEHLHLKSAFEPCQMMPGMLLEQNPQFLYDNPSIFVIGILNLPLKVSPVELYNEFSNHGHILGVAINQSINEDMTHYAEVAVSTYESCIEIIEKFHAIAYEGSILQLFIKQPVQGFCSNLLNHPEGTMTNLLPPNMEMPQPFEIPVIAKTSALPNPFISFPSFQTSYETTVTPTPTSTPTIDPCNLFVKNLDDNIVGNTQQLEELFSKFGRIKSCTLASYPSTEISKGYGFVSFSHPFEAVQAINTLNGVLFGKKRLFVNYAEKREDRKKRLSAIFSQSYPPVVPSPSLTIPMATEPQILEYHQEWPQPLIQSIQQHGYSDPRQTLPTRLDSCAAKLREAVISNENLNPSHKFGIKHSTFKTSLSPLTNIVLNQ