lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVFDTPEEAFGALRPVCVQLTKTQTVENVEHLQAQLQAVSDSALQELQQYILFPLRFTLKTPGPKRERLIQSVVECLTFVLSSTCVKEQVLLQELFSEISACLYSPKSQKPAAVSEELKLAVIQGLSTLMHSAYGDILLAFYEPSILPRLGFAVSLLLDLAEQEKSKQIKIAALKCLQVLLFQCDCQDHPRSLDELEQKQLGDLFASFLPGISMALARVITGDFKQGHGIIVSSLKTFYKTVSFIMADEQLERISKVQPKPAVEHRVAELMVHREAKWVKNTSDKLTILIKKIIECVSGHPHWKVRLALIELVEALLLKCSQSLVGSAGPLLKALVGLVNDESPEVQAQCSKVLRHFADQKVVVGNRAFADILSENLHSLATSLPRLMSSQDDQGKFSTLSLLLGYLKLLGPRVNFVLNSVTHLQRLSKALIQVLELDVTDIKVVEERCWNSGPLGASETAATQPRSPMQRRYFRFFTDERLFLLLQQVCQLLGFYGDVYLLIDHFMELYRESVVYRKQAAMILNELVAGAAGLEVENLHENHIKTSTEELREIVTSILEEYTSQENWYLTTCIESEEVGEELTMKQSGLQAITSGAHTCQVTSFPAFSKPSPTICSMNSNIWQICIQLEGIGRFAYALGKDFRLLLMTALYPVLEKAGDQTLLISQAATSAMMDICHTCGYYSLQHLINQNSDYLVNGISLNLRHLSLHPHTPKVLEVMLWNSDASLLPLVADVVQDVLATLDQFYDKRAASFVGVLHALLAALAQWFPDTDDLRQLQGESAGEAGSHLSQRPAASEKGLENTTTAEDMELFLLNYLKEKDVADGNVSDFDNEEEEQSDPPKVDESDTGPDVEPPLPVQIQIATDVMERCIHMLSDKNLKIRLKVLDVLNLCVVVLQSHKNQLLPLAHRAWPPLVHRLTNDDPLVVLRAFKVLRTLGGKCGDFLRSRFCKDILPKLAGSLVTQAPVSARAGPVYSHTLAFKLQLAVLQGLGPLCERLDLGDSDLNKVADACLIYLSAKQPMKLQEAARRVFLHLMKVDPDSTWFLLNELYCPEQLTPPHPSLHPVQLRGTMGQGNPYAANVLCLLQELQ
The following text describes a protein:
Function:
ABC transporter that may affect phytic acid transport and compartmentalization. May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSRTSTWMVDLCGSPICSKQAAAASCAWKELFDSSTCMNHILVIGIAALIAVVVAIQLLVKIPRSRAPARQLFARSSPLQLAGVVFNGCLGLVYLGLGFWMLGRNFSQDASVYLLHWWLVALLQGFSLILISIAFSIRARFLGVTSVRIWSVLLTIYAAFVCCSSVINMVAHKAVAMKGCLDVLFVPGALLLLVYGIWHIREDGNGNGGTGSALYKPLNAEAADDADDSESHVTPFAKAGFFSVMTFWWLNPLMKMGYEKPLEEKDMPLLGASDRAYNQYLMFLEKLNKKKQLQPHGTPSVFWTIISCHRSGIVVSGLFALLKVLAISSGPVLLKAFINVSLGKGSFKYEGYVLAATMFICKCCESLSQRQWYFRTRRLGLQVRSFLSAAIYKKQQKLSNSAKMKHSSGEIMNYVTVDAYRIGEFPYWFHQTWSTSVQLCIALVILYNAVGLAMIASLVVIIITVLCNAPLAKLQHKFQSKLMEAQDARLKAMTESLIHMKVLKLYAWEAHFKKVIEGLREVEYKWLSAFQLRRAYNSFLFWSSPVLVSAATFLACYLLKIPLDASNVFTFVATLRLVQDPIRQIPDVIGVVIQAKVAFTRITKFLDAPELNGQVRKKYCAGTEFPIVINSCSFSWDDNPSKPTLKNLNLVVKAGEKVAICGEVGSGKSTLLAAVLGEVPKTEGTIQVCGKIAYVSQNAWIQTGTVQDNILFGSSMDKQKYQETLERCSLVKDLEMLPYGDRTQIGERGVNLSGGQKQRVQLARALYQNADIYLLDDPFSAVDAHTATSLFNEYVMGALSDKTVLLVTHQVDFLPVFDSILLMSDGEIIRSASYEDLLAYCQEFQNLVNAHKDTIGGSDLNKVTPNRAKEISIKETNDSHGSRYRETLKKSPADQLIKTEERDIGDTGLKPYIIYLCQSKGYLYASLCVISHLVFIAGQISQNSWMAANVQSTGISTLKLISVYIAIGVCTMFFLLSRSLAMVSLGVQTSRSLFSQLLNSLFRAPMSFFDSTPLGRVLSRVSSDLSIVDLDVPFAFMFSISASLNAYSNLGVLAVVTWQVLFISVPMIVLAIRLQRYYLASAKELMRINGTTKSALANHLGESVAGAITIRAFEEEDRFFQKNLELVDKNAGPYFYNFAATEWLIQRLETMSAAVLSFSAFVMALLPPGTFSPGFVGMALSYGLSLNMSFVFSIQNQCQLANQIISVERVNQYMDIPSEAAESIEENRPSPDWPQAGRVELRDLKIRYRQDAPLVLHGITCTFEGGDKIGIVGRTGSGKTTLIGALFRLVEPAGGKIIIDSVDITKIGLHDLRSRLGIIPQDPTLFHGTIRYNLDPLGQFSDQQIWEVLDKCQLLEAVQEKEQGLDSLVVEDGSNWSMGQRQLFCLGRALLRRCRILVLDEATASIDNATDAILQKTIRTEFKDCTVITVAHRIPTVMDCSMVLAMSDGKVVEYERPMKLMETEGSLFRELVKEYWSYTSNGNI
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MFRSVSTKATPLLLGAVAVNASAGADKPKSAVAEEPNKMVCRPSELPLYRPLNQKIACECHQRRNESTGPASMLEEGFRTIRVQVQEASKLVDDQKKQIVDLFEEGKKQTKFINDYLHQEDNTMPRVGAIAIGGLAGLIFGLRGGFFKRVIYTSFGAGGLASICYPQEAEMYAQHGLVEAKKFATIGYNFVYGVKPGDKQLELPTIPSNLGDLKDSVSGLAKSAYDAVFSEKK
The following text describes a protein:
Function:
Methylates ribosomal protein L11.
Subcellular Localization:
Cytoplasm.
Sequence:
MQPSPTHRASFSIGSEAAARRVVDVLTEVFFEGDAAVAAFERPDGQWDVTLHFADAPDQAWLRELVVNSAGNEIADTLAFDTVEAKDWVKASLEDLVPVPAGRFVVHGSHDRDRVAPNKLKIEIEAALAFGTGHHGTTRGCLLLLDHVLKSSRPSNVLDLGTGTGVLAIAAAKALHRAVLASDIDPPSVRVAAENGRLNEVGHHVRVIRATGFAAPDFARAGPFDLVLANILANPLRHLASPMARHLAPGARVILSGLLTHQAPAVIAAYRARGLVPLRHLRIEGWSSLLLRKVG
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MRPLIVASLPIKKIEDLKLIENFLDADLIELRLDYLREREVSLISDYYEFLDKYKKKLIVTLRDKGEGGINQLADELKIKILNELYERQYLYDIEVSFLQKYDIPYDNRIVSVHYFNYLPTLEKIKEIVSKFSEKAFSVKIAVPSLKGYKEVLLPLLEYENVTVIPMSNNSLERIAVGLLGSKLVYSYAIEPLAQGQLYYKKVIQIFNYINDITTSSLVT
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSLSGLLPPNLGGNSPNADGNLTPEEKAALQQAKIIGYMNRISESCVFKSSMAGVLGFGLGGIFGMFISSLDLQHIDPKIYEKPFREQIRIQARDMGSRSFSTAKNFGLLGLIYSGSECCIEAFRAKTDIYNAIAAGVFTGGALAVRSGPKAIVLGGAGFGLFSYGIEKYMHWGE
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MAKVDSGFVLSHSRVALDIDFVNSSVQGIVELTVTPLVSTLTELYLHCRQCVILSVKVDGILASYVHTDPDEDLINFAKAGSFSKLSEMHLSNSKKPDNGELYIQVPPELECEKMQFEQATLDSSACYRSWTLVIEYIIQQPEVAITFVVSPTDVVPEKRAYPHMFIAPVHNQARWWMPCTDKIHDRLTYEFEITIPRTVSDVYSLSNGYADINHNGLKTLSQRQSRGLDHSLKMVAVCSGELVEQFVHPENACKSVWIYSIQTAMDAASVILAAGPFEILPIHGWGRPTLTTLRNTESALSDEELFENGIQRVGGKGLIFVLPDYKRDIRVSTFFLSQALEFFEQWTGSSFPFSSFKLVFVKESYPSIVTGSTIALASVDILVDETMIDQVYETRLHFAKSLASQWFGHYMAPNRWTDVWVLVGFTNWLAALFMRKMFGNNEFKYRLQQDINRVCELDVNQPPLCPDVSILGGAIDEDGSPAALTISSLISRNFYSNDSTFSARTELMMLKSPLVLNMLEKRMGKNLLQKIANKLMVSAMSGELPTGLSTTHFLKMVRKISGKLETKEFADQWIFRSGCPIFTIRYHFNRKKMVIELRVKQDCSNVDVIGANQRFSGAFMVRVQEPGGTFDTEVRIEEKTKQYDIIYHTKYKRIRRRAGKKYKKVADNDDDDDDEDVYYMEEDEKANDAIADAEAQNQDTNGNFNIIEPDRITFEWIRLDPDNVWICTKTFEQEDFMWNALLRKEKDIGAQSEAIVALSKIQSLASLNTITTFVRDHSHFYHLRLLAVSVLSKFDSDELYSTALGNLIKIYRDIFCISYDGPIIPKKNNFSSLQDYKLRLEIVRSLAKFVDARGATLPVVRMMFVNLLKYNDNSGNEVKIAACTEYILMSVFFNYHYMLYRGQFKYSDGEWVSLLVKLIGDAFIIRPRQDMSAHARTSKRSVLLASTDVEDFEILAGDKHLKAHMSDSLQSTLSPEDQQLFAEAHVQILRQFVRDKVIPSHQNAVTVSCLETLLKWQLVGLLPINLMLFLGYSRVGNFISIRRMAVECLIVLSSMGNSDITEYLVYLVFHESDRQFRYNIFKSMVSFFSISMYGHKPSVTIEQAVTTLSKHAVFLASRTAKEIRSPTSPRLWLLFLRLSEMAAECLESDPELYQLAMACASTVHPSGITLTLSQSLLSGKFNQNLKNQVPAYSQANTSFHSSMEGVAVVPSTSRAPLRMTFSGSNSSVSQNQEAETLQMDMNISTPSSDQKSSVFSNSNSVSETGTKKRSIRNRLIQQRAQTDDSSPAKSFVSTPVAGNTISTGSARSRQQTNSNTRLSFNTTSILQAQSLERMILDELMIRKDAAIFLYPVDATMYPDYYEKIEFPIDLHTIRERVQNSEYGSFQDFEKDIHQLFTNCFIYNKKGTMGHAVGKSLEAFYSRRSKKKDGMPTKGQRNVGSLFTTWDIPQFPKSLPIAIARAERREHIRLQLHKLQNKRSSFASGALGVRQRYSRVLGQIGYEQLPLLPLQDIPEVEVHRDRRLQADSIINTNTNIDNSIQQNAEFESDTVELRENIRAIVTDIESLAWLSAEERQQLVKMISAQQLAGSTIELC
The following text describes a protein:
Function:
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MWLFLGIAGLLTAVLSGLPPPAPSDQHRNGSIPNMSSDPEEQLGIRLVNGSSRCSGFVQVLLESWEPVCAGHWNRAATEAACNALGCGDLGNFTHLAPPTSERPPGATSRNTSSSRNTTWAGAPTVRCHGANWQLCKVEDYECSSDRRLVWVTCAENQAVRLVDGGSRCAGRVEMLQHGEWGTVCDDTWDLDDANVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGVDSCEGQVEVYFRGVWSTVCDSEWYPSEAKVLCQSLGCGSEVDRPKGLPHSLAGRMYYSCKGEELTLSTCSWRFNNSNLCSQSLAARVVCSGSQRHPNLSTSEVPSRVPVTIESSVPVSVKDKDSQNLTLLIPCIVLGILLLVSLIFIVFLLLKAKGQYALPTSVNHQQLSTANPAGINNYHPVPITIAKEAPMLFIKPRVPEDSDSSSESDYEHYDFSSQPPVALTTFYNSQRHRVTEEEAQQNRFRMPPLEEGLEELHVSNIPAADPRPCVVDAPSLGSQYHTRNNKSRANGVSAGLNEQSLATSWWWLRAMLGNPEASSHSMSCALIPSLRKLLRD
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSVVVVGSFNVDHVWRCDALPAPGATIAGRYSTGPGGKGFNQAVAAARAGAKTHFLCALGDDAGGALARSLAAQDGFALIAEPSNEPTGTGGIYVDAHGRNTIVIGAGANSVLSAGFVDNQRALVTSARVLLAQLESPAETVESALALARECGVLTVLNAAPANAPTSISLLKLSDVLTPNETEFAALLGRHVGERINADDVAALDGNTLHSLCRKLLPGGTVVVTLGAVGAFISHAEEQLRGDTQAHYRVGAESAQTVDTTGAGDAFNGALVASLAHSPNASFITHVRFATRYAARSTEVEGAATSMPRMVPEPAV
The following text describes a protein:
Function:
Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as a vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation. The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen. PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase. VTC1 contributes only 3 transmembrane domains to the complex. The VTC complex also plays a role in vacuolar membrane fusion.
Subcellular Localization:
Acidocalcisome membrane; Multi-pass membrane protein.
Sequence:
MASVIEKGLASICCVTTSSKPWAEGEADGDVKYEDLRGPGGRNTSGSVSDKRICVPQKIDPKTFFANERTFLKWMSISVMIGMMSLTLLNFGDTSSNASELAGLVLLPVSILFMIHSLFVFKDRANKIYMREPMRYDDTKGPTILVLVLGVSLGIAAIFSVQKQYYRTASSSFNDGPRFS
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice.
Subcellular Localization:
Nucleus.
Sequence:
MSVIAGHHVPRSNDQRQYDTPSVPINIAPDSEGHIHEMSRLKDYEVIEKLGQGTFGVVQKAKSKKDGSLVAIKQLINHSAKEGFPITAMREITILKQLNHKNILTIQDMIFEEPKMSNRTDIITMRGSFYTVTPYMSSDLVGLLENPKIKLELGQIKCIMQQLLKGIQYVHNQKFLHRDIKAANILIGQDGVLKIADFGLARIYHGNVPRLGMGPGGGEKAYTGLVVTRWYRPPEILLGERKYTTAVDLWGIGCVFAELFTGKPILVGKSDSHQAQIVFELVGSPLTWTDAAKLPNKNEYSCGLACKRSLEAKFASIMPTEAIDLLSGLLTLDPFKRLNALDALNHKFFSTDPLPLLPTQMPKFEESHEIDKERFKKLKDKEQAVSELKPPTEIRYDNHSESRYNADHSTFGGGVGGKETSFSSGKSDYIDHYEPRARRDHYEPRIRNDNKDSNDVRGEFESATRQEQRRRDIQNRLDAGGMDTYIPKTTTAKLREHSGTESLSKKYDNYQPINVSRGSKSPSPSKLSSISQSKADLISKPSAPKVASRESSLERKQVSNGIRTTTDVEPPRARARRPTDMFGRPLTSNSTQAQPTRNKSVERPKDLEKPTNGVTEDRNKKPVLEEKKEVVKPNLAIPKIKKSSSLVSLSSRSSTTPVISNPSKVTKRAASSVTPPVLPKKPKISKTSSESEVSDLEEDSDFTGENATVFERFMALEQLQKSPVYKRIINEKMRFEKLSGGHKSM
The following text describes a protein:
Function:
Could act as a modulator of glutaredoxin biological activity. May play a role in cytoskeleton organization.
Subcellular Localization:
Cell projection, ruffle membrane. Cytoplasm, cytosol. Nucleus.
Sequence:
LSALPPRFSRCPIPTCSARSSVLRASPPRGPPGQIKSQQSEVTRILDGKNIKYELVDISQDNALREEMRAKAGNPKAIPPQIVNGDHYCGDYELFVEAVEQNTLQEFLKLA
The following text describes a protein:
Function:
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import.
Subcellular Localization:
Cytoplasm, perinuclear region. Mitochondrion inner membrane. Mitochondrion intermembrane space. Nucleus.
Sequence:
MFRCGGLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHVPLELQMTRQMASSGASGGKIDNSVLVLIVGLSTVGAGAYAYKTMKEDEKRYNERISGLGLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
The following text describes a protein:
Function:
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus.
Sequence:
MSIPGLGQIAPQAPTTTQRTINLRPFGEWRFSIPHQHSTFSSNSSAAGVTVRLVAGTAERDGTELAPNCVYTFLPGTKSKLFTDQGCTLEINNTGGYPLEDRVVEHPPEQSPMLSYINLHFGLQDHERAAAAQAQQQHPTHHQQQQQGRGAGAGVARSKPGPRVLICGPPGVGKTSLAKLLAALATRMGSQPLVANLNPTDGLLCLPGTLGAAVFGTLMDVEEPAGGFGVTNTPISGPSAVPVKNPLTFYFGHEKVEDDVDMWRQMTERLAVLARRKFERNRDVRVAGLLVDTAPVEAGDKEGQELLGWAVRQFDANFVVVLGSEQLKTELGQRFASEKTSFEEPITVLGLDKSDGAVQIDKAWRQKSTETAIKEYFFGGIKARLSPFTQSASFDELVVFKAPDEPYEGAPVLERVEITPEMAHWTLAVMIASVTDSPQAIRFSSVLGFIVIADVDQERRRVKFLSPVSGRLGNHPLIWGRWPEPYLNLLA
The following text describes a protein:
Function:
Transcription factor acting as an integration node for stomata and brassinosteroid (BR) signaling pathways to control stomatal initiation and development. Activates transcription when in the presence of SCRM/ICE1. Functions as a dimer with SCRM or SCRM2 during stomatal initiation. Required for the initiation, the spacing and the formation of stomata, by promoting the first asymmetric cell divisions. Together with FMA and MUTE, modulates the stomata formation. Involved in the regulation of growth reduction under osmotic stress (e.g. mannitol), associated with a quick decrease of meristemoid mother cells (MMCs) number lower stomatal index and density.
Subcellular Localization:
Nucleus.
Sequence:
MQEIIPDFLEECEFVDTSLAGDDLFAILESLEGAGEISPTAASTPKDGTTSSKELVKDQDYENSSPKRKKQRLETRKEEDEEEEDGDGEAEEDNKQDGQQKMSHVTVERNRRKQMNEHLTVLRSLMPCFYVKRGDQASIIGGVVEYISELQQVLQSLEAKKQRKTYAEVLSPRVVPSPRPSPPVLSPRKPPLSPRINHHQIHHHLLLPPISPRTPQPTSPYRAIPPQLPLIPQPPLRSYSSLASCSSLGDPPPYSPASSSSSPSVSSNHESSVINELVANSKSALADVEVKFSGANVLLKTVSHKIPGQVMKIIAALEDLALEILQVNINTVDETMLNSFTIKIGIECQLSAEELAQQIQQTFC
The following text describes a protein:
Function:
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Subcellular Localization:
Cytoplasm.
Sequence:
MRTRYLIGNWKTNKNLKDAVSFVEQFQQNKLNYNAKIGIAPVYVHLTEIKKIISDSLLLFAQDANFIESGSYTGTVSFTQLQDIGVNNSIIGHSERRKYYNETSAVINQKLFACLKASMQVVLCIGEALGQEISFLKTDLTNCLDTIDKSLIKNLVIAYEPLWAIGTGKTATPEVANQTIKTIREYINDLYDENVANNISILYGGSVDHNNIQKLAIMEQIDGFLVGKASLEIKNFLEMARVYA
The following text describes a protein:
Function:
Assembles to form a prolate capsid shell of about 54 nm in length and 45 nm in width, with a T=3, Q=5 symmetry.
Subcellular Localization:
Virion. Note=Present in about 235 copies in the virion.
Sequence:
MRITFNDVKTSLGITESYDIVNAIRNSQGDNFKSYVPLATANNVAEVGAGILINQTVQNDFITSLVDRIGLVVIRQVSLNNPLKKFKKGQIPLGRTIEEIYTDITKEKQYDAEEAEQKVFEREMPNVKTLFHERNRQGFYHQTIQDDSLKTAFVSWGNFESFVSSIINAIYNSAEVDEYEYMKLLVDNYYSKGLFTTVKIDEPTSSTGALTEFVKKMRATARKLTLPQGSRDWNSMAVRTRSYMEDLHLIIDADLEAELDVDVLAKAFNMNRTDFLGNVTVIDGFASTGLEAVLVDKDWFMVYDNLHKMETVRNPRGLYWNYYYHVWQTLSVSRFANAVAFVSGDVPAVTQVIVSPNIAAVKQGGQQQFTAYVRATNAKDHKVVWSVEGGSTGTAITGDGLLSVSGNEDNQLTVKATVDIGTEDKPKLVVGEAVVSIRPNNASGGAQA
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MIFASTLLAAMLMLTSCVTPMAATDGHYSVNLRFSALTPESVRTTVILNGVEKSATVSAHTTDLTLDYTMSSDQVLDNKPILLEVSVLAGANFETKTLELDRASPRVHSVNDLVRIVAGKSECAKNYYGPFCSLYCAANEALHWTCSSEGVLGCAEGWQGPKCAERACPVACVHGHCDNGAVCRCRPGFAGPACDQCIPAAGCLSGACRNNTPGTCGGCADGWAGALCNIDLSLCSAKKSPCAVGSICIVKAPGKTACICPEGKTGSNCDVDAVARPCPCKNGGRCSPLSIRTPSAVCQCPLGFTGPHCETIAVTTTVTRGGETNQSAIAHNNLLVVMNVILCLVVLLTGTVLILLALRFINSSASGACGRPSSSSRSEESSTRTNENRKKEEKPTQKLSTVSLLMPEDLTTLPPSYSAACTPYSTPSHSSKGDAEKTFVFDTVDEPRYSTCPKKSTVFSIPEPEKTYESLPV
The following text describes a protein:
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively. Localizes to mitotic spindle microtubules (By similarity).
Sequence:
MSEAGVAPIEDGSQNSSGGSSGDAALKKSKGGAKVVKSRYMQIGRSKVSKNSLANTTVCSGGKVPERGSGGTPTRRSLAPHKAKITAAVPLPALDGSIFTKEDLQSTLLDGHRIARPDLDLSVINDRTLQKITPRPVVTSEQKKPKRDTTPVNLVPEDMVEMIESQTLLLTYLTIKMQKNLFRLEEKAERNLLLVNDQKDQLQETIHMMKRDLTLLQREERLRDLIEKQDEVLTPVVTSKDPFKDNYTTFATALDSTRHQLAIKNIHITGNRHRYLEELQKHLAITKSLLEEIMPSHASENAESFDTIKDLENIVLKTDEELARSFRQILDLSFKVNKEISLQSQKAVEETCESALVRQWYFDGSLP
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (By similarity). It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD6 and GCD7 repress GCN4 expression at the translational level by ensuring that ribosomes which have translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail to reach the GCN4 start site.
Miscellaneous:
MISCELLANEOUS: Present with 6650 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSSQAFTSVHPNAATSDVNVTIDTFVAKLKRRQVQGSYAIALETLQLLMRFISAARWNHVNDLIEQIRDLGNSLEKAHPTAFSCGNVIRRILAVLRDEVEEDTMSTTVTSTSVAEPLISSMFNLLQKPEQPHQNRKNSSGSSSMKTKTDYRQVAIQGIKDLIDEIKNIDEGIQQIAIDLIHDHEILLTPTPDSKTVLKFLITARERSNRTFTVLVTEGFPNNTKNAHEFAKKLAQHNIETLVVPDSAVFALMSRVGKVIIGTKAVFVNGGTISSNSGVSSVCECAREFRTPVFAVAGLYKLSPLYPFDVEKFVEFGGSQRILPRMDPRKRLDTVNQITDYVPPENIDIYITNVGGFNPSFIYRIAWDNYKQIDVHLDKNKA
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDAQAARPSRQSDAAASQIQRSRAATPSLTHKASTVSTTDTFASATDGQGYYTDAADVSAYHDDVRSRFDSVPNTINGYGLDQRDGEARLPRSSCSRTDEQGDVMITNVHEPQITSPQLQANPQQPPIEAVASPSICSNRNACAEEAGKPTGCEQQSCVPDAYHRLARHAAIVGLLMFSAIWGTLAREGMVALNTYDGESVAPLIWAQAVGCLIMGVAIGANREPIERTYPPAYIMITTGLCGSITTFSKWMLDVFRAFGDQRHFDRGGLHNVMDALSQTAVTLGMALISVEAGVALSSVVNVEKLVAAFHHWRSRPGLHPSRTPRADLTDGESKTHMVQARPTLILDTCMFLLGLIFWIGCALLCALYGGFRHVTFSLVLAPAGTVARWYLSRLNTHALSRRFSLPLGTLAANLLATALICAAFTASRAGSMPTSFAGRLTGCQALQGLQDGFCGCLSTVSTFAVELRTIKPRRNALRYALLSWLAGLLLCVLLLGAPWWSVGMDGRCLGYPM
The following text describes a protein:
Function:
May be involved in the late step of 60S ribosomal subunit assembly or modification in the cytoplasm.
Miscellaneous:
MISCELLANEOUS: Present with 19700 molecules/cell in log phase SD medium.
Sequence:
MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMFDNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGDEGVSLVFEVPN
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKLHGFSVSNYYNMVKLALLEKGLPFEEVTFYGGQAPQALEVSPRGKVPVLETEHGFLSETSVILDYIEQTQSGKALLPADPFEQAKVRELLKEIELYIELPARTCYAESFFGMSVEPLIKEKARADLLAGFATLKRNGRFAPYVAGEQLTLADLMFCFSVDLANAVGKKVLSIDFLADFPQAKALLQLMGENPHMARIMADKEASMPAFMEMIRSGKR
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MMPFLLIDFPAFKPIAIEIGPFAIRWYALAYICGIVFGWLYARSLLKNERLWGGPAPISLVQVDDFILWVTLGIILGGRTGYVLFYNLPFFIEHPAAIFRLWEGGMSFHGGFLGCVVAVMWFAYRNGIPILSLGDITTAVAPVGLLLGRIANFINGELWGRATDASLPWAMVFPNDPTQLPRHPSQLYEAGMEGILLFTVLAIMIRLGALKRPGMILGAFILIYGLTRIAGEHFREPDVQLGFLWGGLTMGMLLSIPMLIVGLILIVLAIRRGAPRPIEAIR