lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MKSSLRIQSTLGLLFRPCAVSAPATAPGLNAHARWAHKTAAQLPLIPKPTPFVPDVPTFLTLIGRDLKQHADKFPTWEALFTLTTDQLRELGVEPPRARRYLLRWRQRFREGKFGIGGDLKHVENGVAYLKIHEKEASPTRTSRRVVNVPANQHVEEVSEGERVKVKGYKVKGVSTIVGPYALPVQKGVAKLAVTEGMWEDKRGHKVDGGERRRAEVRFKRGVAERKALREKMGFY
The following text describes a protein:
Function:
Required for maintenance of normal mitochondrial morphology. Required for PCP1-dependent processing of MGM1. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid release requires dissociation of the UPS1:MDM35 complex. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane. With UPS2, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.
Miscellaneous:
MISCELLANEOUS: Present with 704 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space. Note=Lacks the two major intermembrane space-targeting signals, bipartite presequences and cysteine motifs, and import is mediated by another IMS protein, MDM35.
Sequence:
MVLLHKSTHIFPTDFASVSRAFFNRYPNPYSPHVLSIDTISRNVDQEGNLRTTRLLKKSGKLPTWVKPFLRGITETWIIEVSVVNPANSTMKTYTRNLDHTGIMKVEEYTTYQFDSATSSTIADSRVKFSSGFNMGIKSKVEDWSRTKFDENVKKSRMGMAFVIQKLEEARNPQF
The following text describes a protein:
Function:
Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFFLSLFPILVVLIGMLVFYRSGSFVSVIGWILAVIVAAYYFKTPWNVIMGATLTGIVKAFGISLAVVFTMFLIFLMRETGALKKIIEYVKGIARNKEEQTLFIGMGFGSLSTSLGMVTPAMFPPIFLLLGFSPIAAIGVSILCYDPLTSFALFTIPLTLPSKVAMAFGIKPPGIENLNEFIWDYTFKVTVLLPVISIIFAFLMLKVVGGKQAIKKNWKAALISGLVLSGSALVIAGFRILPVEIIGIISGLITMITVYFIYRKHNNRATDTNLPFNKEMFKACLPFILLIIISLIVNIPSLKMNLENILGQTEVIRIIADKKEDLNILGNVWFWIMVVSFISIFILKPTGKQLGNVFKLWITRIWGPFLAYSLFFAVAFIMAWSAMEVVNGKLVPSQYFAQYNMDRIIGITLANIFGPAYPFIAPFLGLFGAFVGGSETASNVLFAKIQWEATLSTVGANAFMWIYAAHAVGGGIASAITPSKITNAAATIGVGGKEEAQFIKAVLVPVLLMCVITGAMLMVIVYL
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In the absence of phosphorylation and in association with tacc3/maskin, also acts as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Requires zinc for RNA binding. Involved in the cell cycle progression from S phase into M phase.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Membrane. Note=During mitosis localizes with tacc3/maskin and CPE-containing mRNAs to both spindle poles. Membrane-associated. Colocalizes with members of the polyadenylation and translation complex factors (cpsf, aplp1, tacc3/maskin, aurka, etc.), including CPE-containing RNAs.
Domain:
The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA.
Sequence:
MAFPLKDDLGRAKDCWGCPSDTPALSTCSNADIFRRINAMLDNSLDFTGVCTTPNTKGKCEHLQDYQDTEGPAASRMLFSTSHEPLPRGLPDTNDLCLGLQSLSLTGWDRPWSTQDSEAGGHSSTPTAAQSVFSMLNSPMGKPSPLGFLTFDPIGSDLMEKYPTPLLRSSRLDSRSILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLPLGGGVSRDPLKLGIGSRLDQDHAALAAATVSPLGITKGWPSTSVWPSWDLLDSAEDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPVYSCKVFLGGVPWDITETGLINTFRVFGALSVEWPGKDGKHPRCPPKGNMPKGYVYLVFESEKSVRALLQACSQDLLSQDGLSEHYFKMSSRRMRCKEVQVIPWVLADSNFVRSPSQRLDPSKTVFVGALHGMLNAEALASIMNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVSAAFVEIKTAKFTKKVQIDPYLEDSVCQVCNAQPGPFFCRDQVCFKYFCRSCWHWQHSMEILRHHRPLMRNQKSRDSS
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).
Subcellular Localization:
Golgi apparatus.
Sequence:
MAEERPPRLVDYFVVAGLAGNGAPIPEEKWVPEPTGPLRPPRPAEPITDVAVIARALGEEVPQGYTCIQTSAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKLGFQVLDTTPYSHSANLAPPGPGHPRTYLMYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYCRLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLMSAVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPADVICVDLDTNTLFQKEEKKPLSARTLPRRPYKLLLATLTSLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRTRLEREVQGAFLRFMACLLKGYRNFLRPLTQAPSEGSRDVDNLFYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVDKVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPPVLEGSESTPQYCYDGFPELKAELFESPQEQQGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSATVPELWARCLLGHCYGLWFLCLPAYVRSVPSRVRALHTAYHVLREMENRKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLKDRRQQQQQQQQQQQQKQQVAEQQKSGSSQTEPYLERPSPTRPLQRQTTWAGRSLREPSSPMGRLVKSGSLGSARGTQPTVEAGVAHMIEALGVLEPRGSPVPWQDGSLSDLSLTGEEMAPGGSPGGSGSALSAQSTEALEGISGRGSKTSGCQEEVGTPRKGLGARLQQLLTPSRRASASRIPPPELPSDLPPAARRSPMDSLLWPRERPGSTASESSASLGSEWDISESSLSSLSLRRSSERLSDTPGAFQPPSLEILMSSCSLCHACDSLVYDEEIMAGWAPDDSNLNTTCPFCACHFVPLLSVQTLDSRPSAPSPKSSLAGASGCKDAPAPGGPGPVLSDRRFCLALDQPQLCNGHMGSASRRVENGAWAYLSPLVLRKELESLVENEGSEVLALPELPAAHPIIFWNLLWYFQRLRLPSVLPGLVLASCNGPPPSQLSQGPSPWLTPDPASVHVHLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPSCLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKDHVDIVAFDKKYKSAFNKLASSMGKEELRQRRAQMPTPKAIDCRKCFGAPLEC
The following text describes a protein:
Function:
Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons.
Subcellular Localization:
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B.
Sequence:
MALSVDSSWHRWQWRVRDGFPHCPSETTPLLSPEKGRQSYNLTQQRVVFPNNSIFHQDWEEVSRRYPGNRTCTTKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIMIKDGMEDFKRHRFDKAINCSNIRIYERKEQTYVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSDPNGICHLETASLDGETNLKQRCVVKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQTRTGFGCESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGILILMCLIGAVGHSIWNGTFEEHPPFDVPDANGSFLPSALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFFLSNDLDLYDEETDLSIQCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCTIMGSEYSHQENAKRLETPKELDSDGEEWTQYQCLSFSARWAQDPATMRSQKGAQPLRRSQSARVPIQGHYRQRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRPAKASLSTTSSIADFFLALTICNSVMVSTTTEPRQRVTIKPSSKALGTSLEKIQQLFQKLKLLSLSQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSGTSLEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQVTVRLPQGTCLTFSLLCTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPACVPDINMEKKLRKIRARTQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELLMETAQHLENQLTLLGATGIEDRLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLLNQTDTVYTINTENQETCESILNCALEELKQFRELQKPDRKLFGFRLPSKTPSITSEAVVPEAGLVIDGKTLNAIFQGKLEKKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSSSTMIDYWQMIFFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQNSECYNLSTFWISMVDAFYQSLICFFIPYLAYKGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTIFHGVVLLGSFLMYFLVSLLYNATCVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVALLPRYFFLSLQGTCGKSLISKAQKIDKLPPDKRNLEIQSWRSRQRPAPVPEVARPTHHPVSSITGQDFSASTPKSSNPPKRKHVEESVLHEQRCGTECMRDDSCSGDSSAQLSSGEHLLGPNRIMAYSRGQTDMCRCSKRSSHRRSQSSLTI
The following text describes a protein:
Function:
This protein is a multifunctional enzyme, able to activate and polymerize the amino acids Glu and Ala/Val as part of the biosynthesis of the lipopeptide antibiotic plipastatin. The Ala/Val residue is further epimerized to the D-isomer form. The activation sites for these amino acids consist of individual domains.
Sequence:
MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQLDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKEHCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDFLHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTDQIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGSVISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYDIQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVIPGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIVSQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAVEHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGNVEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEEEAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYNNRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRSFAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKLELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRGLLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHELNRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGVGPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSEKTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQRSVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQLKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPEVSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGELCVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQVKVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLLARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIWQEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIRKSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKKLAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQQSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTIQLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKRDSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGREHILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKYLTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMSAMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQSLTAEDLDSISSLVEEL
The following text describes a protein:
Function:
Flavin-dependent oxidoreductase involved in the biosynthetic pathway to 4-hydroxyindole-3-carbonyl nitrile (4-OH-ICN), a cyanogenic metabolite required for inducible pathogen defense. Converts indole cyanohydrin into indole-3-carbonyl nitrile (ICN).
Subcellular Localization:
Endoplasmic reticulum. Cell membrane. Secreted, cell wall.
Sequence:
MKEALFGLYLVLLVSGLEAAVTKPNSGNFIECLRYQASPENPITDAIFTVDNTTTFLSSYVSYTKNTRFSNPNNKNLLAIVVAKDVSHVQATVVCAKSNGIQIRIRSGGHDNEGLSYVSSVPFVILDMHKLRDITVDVSSKKAWVQAGATLGELYVKIDEASQTLAFPAGICATVGAGGHISGGGYGNLMRKFGTTVDHVIDAELVDVNGKLLNRSTMGEDLFWAIRGGGGASFGVILSWKINLVEVPKIFTVFQVNKTLEQGGTDVVYKWQLVANKFPDNLFLRAMPQVVNGTKHGERTIAIVFWAQFLGRTDELMEIMNQSFPELGLRREDCQEMSWLNTTLFWAMLPAGTPKTVLLGRPTDPVFFKSKSDYVKKPIPKEGLEKIWKTMLKFNNIVWLHFNPYGGMMDRIPSNATAFPHRKGNLFKVQYYTTWLDPNATESNLSIMKELYEVAEPYVSSNPREAFFNYRDIDIGSNPSGETDVDEAKIYGYKYFLGNLKRLMDVKAKSDPENFFKNEQSIPPLLSRVRRDDEL
The following text describes a protein:
Function:
[Peptide P3]: Neuropeptide ligand for the G-protein coupled receptor aex-2. Activates and regulates the rhythmic calcium influx in DVB GABergic neurons during the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.
Subcellular Localization:
Secreted. Cytoplasmic vesicle. Note=Secreted by intestinal cells and subsequently endocytosed by coelomocytes. Co-localizes with snt-2 on the cell surface.
Sequence:
MKLVILLSFVATVAVFAAPSAPAGLEEKLRALQEQLYSLEKENGVDVKQKEQPAAADTFLGFVPQKRMVAWQPMKRSMINEDSRAPLLHAIEARLAEVLRAGERLGVNPEEVLADLRARNQFQ
The following text describes a protein:
Function:
Methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC. The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC. The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone. The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin. Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin. Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity). Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH. Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin. Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death. The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway.
Sequence:
MLEKVFHEKSFADQYTYGAKISELYAETLITESGIAKSHQRPLIILDNACGTGSISSTLQRTLDERNKRSLKLTCGDLSEGMVDYTKQRMQAEGWNNAEAKIVNAQDTGLPSDHYTHVYTAFAFNMFPDYKAALRECLRILQPGGTLATSTWKTANWCTIMKPVIATMPGQLSYPTMDEINTMLNKGWDRESDVRAEFEQAGFDHVNITTVEKQCLLPVQEFGEACKILLPYILSKFWTQEQRDQYEADVPSYLMRYLEREYGKDGLAPMKGVAIIASGRKP
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDTRSDCQKLGSPEIARHQFLLTVLPLPAPPTYNCLLTTNLHLPLKLATGNFFLQQLQLEQLHLQVTLSSTIMAPYTKPETVLRRSEELLSVNQPMSALASISEIFSSKRFRQTPLSSLEPIMLRFIDLCVLLRKTRNVKEGLHMYKNVAQNTSVSSVEMVVQHFITKSKEKLDEALAKVDEIEGPLVAEGADQENGAALVDDLEATETPESLLMSTVSEEKSRDRTYRELVTPWLRSLWEAYRTALDILRNNSRLENFYQQIATEAFEFCLTHTRKTEFRRLAETLRSNLASSQKYTNQAHSINLSDPDVLQRHLETRFQQLNTSVKLELWQESFRTAEDINGLIGLSKKVPKNHVMSAFYEKMIRVFGVGENHLFHAAAYNKYFTIQANVAADQPDKLKKLSGLVLLSALAVPVVGSSTSTNEPQRKMRDNEEDSNSLNKTKLGRLASLLGLTSLPTRANLLKDALMRGVLKKSSPELHSLYEILEVDFHPLSITSKIQPILQQLSEDEETKRYVEPLKEVVLTRLFQQLSQVYDSLKLNRVIKLASFGDSEPENLKITRIRVEKFLMEACKRGELEVTLDHSSQLIKFTDRMFENETNSQISSTQLPTSNIPSLLSFNKDQDLVPTQSLAKSGVLQPNSASLLRTHLTRLASALTVSLNHIMPVLSTINETATPDLHLVKSVALQALQIDGPKQRKMLQKRKVTIEERKRKVEELRQKQDIEEAKAKALRIIQIQEEQQIRLQKQNKEREIKKLKDEADKIRAAEAEKVAMALAAQAGLNVDIKNLKGVDTNTIIQMGVEQIEKEKKELAAKMKTVNKRLDHTERAMRREEIPLLAEDYKLQQIRDETNMKKLQEELVEGLQTKHANEVTIKHKLQKMMPDFLKFKERIANQRGHDYKKAKEESLIKIEQAKIERRAQVVKERKLAKAKAAEELKMKEEEERLEEERKKKQAEIDEQERILKAEAEAKAKAMREEREKERAAAAEMAAKQAQREAEAMAKRENKKLAERAAAPPSAGPAAPTAEPWRRTGPGIGAGAEAGAIVSGVAASAAEARPPVVAELKRPTILPGATKAGGWRERLAMKGGEESESTSPVGGLSRVSSASGTRRDNLPPPSTGTGGSGNAYKPPQNRTEPGSGANSRTPSGRGASRW
The following text describes a protein:
Function:
Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Synapse. Presynaptic cell membrane; Peripheral membrane protein. Note=Associated with plasma membranes from synaptic junctions. Not detected in synaptic vesicles. Detected in presynaptic nerve terminals close to the active zone. Detected in synaptic ribbons of ribbon synapses of retinal photoreceptor cells.
Sequence:
MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAESQPHQPPLNIFRCVCVPRKPSSEEGGPERDWRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAVSSQDTATPGAPLHRNKGAEPSQQALGPEQKQASRSRSEPPRERKKAPGLSEQNGKGGQKSERKRVPKSVVQPGEGIADERERKERRETRRLEKGRSQDYSDRPEKRDNGRVAEDQKQRKEEEYQTRYRSDPNLARYPVKAPPEEQQMRMHARVSRARHERRHSDVALPHTEAAAAAPAEATAGKRAPATARVSPPESPRARAAAAQPPTEHGPPPPRPAPGPAEPPEPRVPEPLRKQGRLDPGSAVLLRKAKREKAESMLRNDSLSSDQSESVRPSPPKPHRPKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKLLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQDEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRASARESKATTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPADHRSRHVESQYSSEPDSELLMLPRAKRGRSAESLHMTSELQPSLDRARSASTNCLRPDTSLHSPERERHSRKSERCSIQKQSRKGTASDADRVLPPCLSRRGYATPRATDQPVVRGKYPTRSRSSEHSSVRTLCSMHHLAPGGSAPPSPLLLTRTHRQGSPTQSPPADTSFGSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKVKVHRFKQTTGSGSSQELDHEQYSKYNIHKDQYRSCDNASAKSSDSDVSDVSAISRASSTSRLSSTSFMSEQSERPRGRISSFTPKMQGRRMGTSGRAIIKSTSVSGEIYTLERNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRVGPDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLAPLTRRASQSSLESSSGPPCIRS
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MRNSRIPFQWLRASLALLVVLQSHVMATEASGVGADWEYSYDPCNELGPQHWGDLHEEWETCKTGEQQSPISIKPSNIIVSTSLGSLRTNYGTRPAFLQNKGHEILVNWRWSPGDLVIGEKTFHLRQCHWHSPSEHELYGKRYPLELHMVHTTPAGEIAVIGMLYEFGPFADPLLHQLSEGLIALQTQDNVNVGTIRPPLIGEREPYFRYSGSLTTPPCGEPVTWTVMKEVKRVTESQLASLRIPVHDKDNARPVQPINGRNVYMYEPPHEDHASS
The following text describes a protein:
Function:
Probably plays a role in anchoring the complex to other cellular components.
Sequence:
MASGTLYTYPGNFRAYKAQVAAQYSGAQLNVVSDPPAFKLGETNKTPDFLKKFPVGKVPAFEGKDGTCLFESNAIAYYLGNDQLRGTSPKSAALVQQWVNFADSEILPAACAWVYPTLGIMQYNKGNTDQAKEAIKKVLTVLNEYLKTRTFLVDERVSLADISVACNLLLPYQQVLEPAFRQPFVNVNRWFVTCVNQPQFKAVLGVVKLCDKMAQFDAKKFAELTPKKDKGGKKEKQPQQPKQEKKKEKKQKEEKEVDEADDLPKEPKSVDPFAALPKSAFNMDEFKRTYSNKDTLTVALPYFWEHFDKEGYSLWYSEYLYQSDLNMIFMTCNLVGGMFQRLEKLRKNAFANVCIFGEDKNNQIAGVWLMRGQELVFPLSPDWQIDYESYSWRKLDPDSEETKLLVREFWSEEGDFKIMGNRKYNQGKCYK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MADSIAAFQTRLASVMEVLLNAAVSEITDLVECSFSAFRVEIAHYKKENQALKLRLLFSGCESGADRGDRVSPAGHAARSASRGRVGVRVCEDSALGETGAGRQAQHCRPRDAEEQAPEESADLTELPPDSVPEEMLDLEAVIIKEESTATEEPRPDSLLVKEERPEEDSAHSDLWAAPGRRAVEACAPVAPGERAPIAQPPCEWERGSQPTVPDREEQHRSRRCAEGLGGAESESVAQELRPLGSNLRPDGLHTPEKSTGRSSEMGFISTQGHSTEGRNELDSCDIVEQDTDFQSVYTIENETQTQFVQIKEESTNRNRPASCLCSDYTNPGICMLDSIHIKDETEPQSAHSVAERSELDHNEWQRQRGDSESREEQPMYVIKKNLSQDLEMILRPLSGTVGSPSLQCGGPSSALTPVPVREDSAETSGHTQGHNLCVLCGRTFRTPHSLKGHQRIHTGERPYPCTMCGKTFSYIQNLKVHQRIHTGERPYCCTYCGKTFRQFANHKKHVHIHTGERPYPCAQCAKRFKHLADLKVHQRTHSGERPYGCAQCGKTFTHPHSLKLHWEVHSRERQYSCT
The following text describes a protein:
Function:
Involved in the regulation of gamete interactions during the double fertilization and to prevent multiple-pollen tube attraction; mediates the redistribution of the gamete fusogen HAP2/GCS1 to the cell surface after secretion upon sperm arrival.
Subcellular Localization:
Cytoplasmic vesicle. Secreted.
Sequence:
MTMASHHHLTPLITFTTCIILAYTGSSRDIFVPLVVNSGTNNTVVNGTQNNSDCWTALYEVKSCRNEITSYIKNGTMDIGGSCCQAIKTITHDCWINLLNVVGIPVKESNVLRGYCDVNSSSTPVTDPVSCQVLSEPTSVNISNGTTV
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
Miscellaneous:
MISCELLANEOUS: Association with CENPA-containing complexes may be indirect and due to the proximity of centromeric nucleosomes containing histone H3 with those containing CENPA.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore.
Sequence:
MRRTVPRGTLRKIIKKHKPHLRLAANTDLLVHLSFLLFLHRLAEEARTNAFENKSKIIKPEHTIAAAKVILKKSRG
The following text describes a protein:
Function:
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.
Subcellular Localization:
Nucleus.
Sequence:
MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRAGSSDDRQIVDTPPHAAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFSRRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPGNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDAAKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV