lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Sequence:
MLDDRSKSGMNIFSEAIVEWYKEYKRDLPWRESSDPYRIWISEIILQQTRVAQGYDYFLRFIKRFPDVKALADADEDEVMKYWQGLGYYSRARNLHAAAKSMNGVFPETYPEVLALKGVGEYTAAAICSFAYGMPYAVVDGNVYRVLSRYFGIDTPIDSTEGKKLFAALADEMLDKKQPALYNQGIMDFGAIQCTPQSPDCLFCPLADSCSALSTGRVTQLPVKQHKTKTTNRYFNYIYVRAGAHTYINKRTANDIWKNLFELPLIETPVALSEEEFLALPEFRSLIASGENPVIRLVCRGVKHVLSHRVIYANLYEVALPEDTKSFANFQRIRLEELDKYAISKLVQTLIQVISNK
The following text describes a protein:
Function:
DNA-binding transcription factor that is essential for male fertility, spermatogenesis and meiotic prophase progression in spermatocytes under non-stress conditions. Positvely and negatively regulates gene expression to ensure progression of meiotic prophase beyond pachytene stage in spermatocytes. Plays a role in male germline meiotic sex chromosome remodeling and silencing through regulation of SMARCA4.
Subcellular Localization:
Nucleus. Chromosome. Note=Expressed primarily in the XY body of pachytene spermatocytes.
Sequence:
MEALLSTPINPNNFPAKLWRLVNSPRYRSIRWDGRGEGLLIDQPLFEAELLSPPGPGGGGGTAGAGAEPELFKTTSFTSFIRQLNLYGFRKVVLGGPGGGKPAGNGPLHHFHNPHFRRDQPQLLVHLKRLTSANKAKLAAGLEVPCRPPNRFQRLLITSASAATAPLQHQQPPPPAGPRPEPHGPVAVGQFHRSFRRDSLSPYSCVSTPSHDHSTYPLKGLDRTPVPHRIWQNSLGMHPGQVETSPTFSDKGVPFPVLQRFPTEVTYTLQPSTTSVHVQQGPQTMVSSSQKYSNYTPSAQYSQAYYPTAVLQCCSPTHMDALSSCVTPTASSYAHCNYFQNPSMQSSYPVEFLPSNWPCSTTDENTKTEVNLEAVFQIVDELHSSPKLEMVKVEPVENQCPTSPSYRGQHILANSNNSNPCSASQASQLEPLTPVGSDIMSFVVGTEQAVACSLPQSPEYIYTIHTAQPVENSTIQESAAIQQAHVKLKEHLNHNPSPSSVVFVQEGPPFSTHQVDANIKCQTSSRENILPSEQMGFLISEMGPASKPSEDTGLATPARYREHRSNSQQGKSPDLHLLVDVACKQERFPKEEELKE
The following text describes a protein:
Function:
GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
Subcellular Localization:
Golgi apparatus.
Sequence:
MGLTFAKLFSRLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATTGEGLYEGLDWLSNNIANKA
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
IKKISNNIFLIMLIFGTLVTISSNSWLGAWMGLEINLLSFIPLMNDNKKNLLTSESSLKYFLTQAFASSILLFAIIMLMFLYNNNLSLYNSFNEILILSTLLLKSGAAPFHFWFPEVMEGLSWVNGLILMTWQKIAPLMLISYNFIYNFFMISIILSMLIGSLGGLNQTSIRKLMAFSSINHLGWMLLAMMNNEMLWMTYFLMYSLLSFSIVLMFNNFKLFYFNQIFNLSMMNPIIKLLIFLNLLSLGGLPPFLGFLPKWLVIQNLTAMNQLFILTISVCLTLITLYFYLRLSYSIFMLNYQKNSWMLKNNFNNKMSSISLIFNFISIGGLVMISMIYIIM
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAVAEAWCALNAQLTSHGHDAINRLDLAGCGGRMAKLTVLSESATHQLVDTVKQILATRTDQAAVIAQLQEQNTLLQQDLDRGRAQQDNAAQLARDYDDVQERLMHEQRLRDAEAQRFAAQMQARDAAMVHHESKMKAAQQRIDSIRTERDQMRQSHADLVAERERHQKRLDRLFEELQHRKLHAKSAIDRRVRDVIDLYDGRLRQLQQELRVARDALDRQALAPSPSSNVARDADDSARSIDARIVHLQAQVDHQSERRLAQELASMSHALGAAKDDNDRLRAALHTRDEELNMAKMQLESLPSPTVWRQTQARLRRLEARQTQQATSNSPSTKSPGTGKDGREHDPQYYRLHLYNLRSLSASAARQQLERLCRICEVAPSRLEATLRQWTSVMTALPAYLAHMAKLSAVINAYREVVAGRQAHLDHDALDQALRAADERGTLTLSDLQPLDVPRADPGLAGIVARGLHELMGLRATVSSYHAALGRVAHIVGLDPVAANSQYTEEQLDGLLAHVTDLRATASQLAAVHAHWTQAEAALAQGPAHPQDSADRVQATLRHCMQLLGVSSLSQLAPEMSRYHAESRALYNLVRMLHVESGFFHSAFTSPMATIEAVLAHLQQHGQSGTILARLQEIAACANAEQLVPHLEHMTTALASTKAQAEEYHRHLLATAALAQHSAKTQQKPTREVAAVATSTSTLTVAPTLFTKASQTDRVAVCSTAVQTEVPSMPESVGTKDLCTSGPVLPASPAETGEEVLRFHTSDLDSTPTTKVHSTPHERLSHLSARDHSSDLSPLNSQASSVHLASREWLAHSQGNTPHMSALSTPASSVGLESDDLLTDEQSGSIQKDEERPPIATPAMVGAQTSPTEASLEADRGDDFTGDSAHMAADLDDDLLALEAELLMSASEATATSARTPTTTTDGRSSRLAVFADVEPPATPTTRAVEPRQQTLSPVAQLTRGEHAINTSKQRSLPQSPLVQTLRLNKLAPGSAAKQSPHPLSTVTNSQHIARGHTTSSGQHSHDQTDASPAKLGTFRLLSPFDV
The following text describes a protein:
Function:
Involved in the cell polarity process where it is required for the correct termination of microtubule growth at the cell ends during interphase.
Subcellular Localization:
Nucleus. Note=Nucleus; nuclear rim.
Sequence:
MVVCKYFLQNRCRYGTNCKNQHTVPSNGQNAFSKVNVFRPENGRPPIWVQRRLKRSDLDNLLPNRRMKDINDDLKNAKPQWPFTGYSVVENLPSIYEGDVSPEELRWWAYQAKATNNMQAYEQRQKQLMDDVEAKAAAVKRSPAAAFDEMRNKLVGKTNYKSIFDKSTSNSTVTSNQFNKPTQNSPFNSFSNNNNSFNNNQQANDIFGAPTTSAFTSQLNASPFSQNTSSNSFTGSNPVQNNPSSFGSSSFGSATSGPSAFGGISQPNSSFVNSGQGIPNSSFSSFSQVASGFSQSQNVNDPSSIFGPTVASGFGIQNQPQQSAFQNLNTQFSLPNNSQPVFGHTSLTQPVNPNGFTVQPPATFMQQPQGPFVPPNTTFESPFANVTSKISASGFSNDNPANKNIIQTPMFGSSNTIDGPINPIGASSIQTLDDQVEMSNSNQNLAFPPEMIQQFEAQDFIPGKVPTTAPPPQFC
The following text describes a protein:
Function:
Required for growth under high NaCl, alkaline pH and cell wall stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Punctate foci at the endoplasmic reticulum membrane.
Sequence:
MQNAQIKSSSKGSGIDGTDRNSKDGVEKRPLEDVKQMIDAGTPDVGHKSTVETKPNVGWQASHSNLAALHEKEQKYEMEHHHARHKLHRQVIPDYTSASTAMFSDCMFNAAPDKVRSLSTMKSSGLSPKHPFNVVATFKGPFPQHSVESKPLDGGYSAKDHFPSFKMLQAQQHPAHRHYKDNDKYGLKSPSRSFVKDKKRLVHRFLKSMEPSSSGQSKDSSALAPAFDPILPNVISKPSKRPTHHSHSSDGSSSTQTDISLQSLLYHDLESSPKKHVSPSRPPSVASESSPAVANPIGLSPKDACNASFSQSSSSSLSSSSSSSSSTSFSQSVAVDPLEPPGNITYSSSNLSLNSDELDYYQRHIGLQLQQTEALLKHSLKDEVLKDENDLVKNIANFDKIVKELRDLRSRTIGWKELVEEDYLMNLKQDFDKENPESFEARLSDTINTNVAKLQDLEKRMASCKDRLASRKEVMRKMESLLSLENSLMISKKNVTFASKYRNEALDIVFLIIIIVICYTFKHLVSHK
The following text describes a protein:
Function:
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence:
MWNDEDNNPYGSFERRDSFASSTNPASPTARDYSIDARFPTPQDVRYDAPLTPSDAGDDEVPGPTYPREASDAATDDETDDQAHGELVPRRKPGGYDSRIEQMLYENPELPILITEAGKSQESGGRFIVYTIKTGDLTVRRRYSEFASLRDALTRLHPTLVIPPIPEKHTMADYAANPTNAKQDQQIIDLRKRMLAVFLNRCRRMEQVRTDGVWWRFLDPNSSWTEVLHSHPVSSIPKQIMKAPPLDPANPTAGHSFLPVPSSSAKLKTLPTQALDSAAAASLARFPPDANSLSEQDLDAYFIAFETSIKDLESLLTGPMEKVNRRTLNHLSSLASDLSELGARYNAFALSETAPTVSAAIERVGQAADSSYIATEELSTSLSASFAEPMRESAQFAGVVRNVLRYRILKRVQQEMTTDELNKKKALLESLERSEAEARRIDQYLSSSQQIQPPRREPPAQHRRDGSGEDTASIDSDFPPTHSDFSQAPSAKIGAPERTGGSPSHKKAASTSITNKIFGPIRHAVQGVVDVDPERTRRDTIGKTRESIVQLEQAQIASAKDVKDASASVLKDLKRFQREKEDDLKRYMLAYAKSQIEWAKKNQETWEEAKAEVNKINES
The following text describes a protein:
Function:
Nuclear serine protease which mediates apoptosis.
Subcellular Localization:
Nucleus.
Sequence:
MDGNADTGVDDFQKKRAAAKELLNEIDGLRPGASATAEDWRKALAKVVPAVVVLRITGVRAFDTESASSSYATGFIVDKKLGLILTNRHVVKPGPVVAEAVFLDREEIPVHPLYRDPVHDFGFMHFDPAAVQFMDLEEVPLVPEAATVGLEIRVVGNDSGEKVSILAGTLARLDRDAPHYKKEGFNDFNTFYIQAASGTKGGSSGSPVIDCHGQAVALNAGSKSTSASAFFLPLGRVVRALRFLQTSRPDTALPGWPAPQIPRGTLQTTLVHKGFDEVRRLGLGRETEGLVRASAKQETGMLVVDSVVPAGPAHGQLETGDVLVRVEGQIVTQFYALEALLDDSVGKRISVEVVRGGQAITTQLLVQNLHSITPDWFLELSGGVVHPLSYQQARNFRFPCGLVYVAEPGYTLARAAVPKHAVIKKFNSRETPDMAAFIEVLGGLQPGAKVPLEFVTNSDRHRGKTVLVTLDRHNWYGPPQIYTRDDTTGLWQPRPAFAKTPKLTPSSDLDRISNLPALEARKLLSGKEENGLAKSEGGSGDAKPSVAKGNGSGPGPAAESAGLRAESDGDRASPNKRRRLEGPEGSVPEANGRPDADGESRREGAGGGVETAGDADPQEVTAHAVEQILEPSFVMMDVHIPPMALLDGVHAQHFIGTGLIVHHSPTLGLVAVDRNTVPISVGDVMLSFVAYPVEIPAEVVFLHPVHNFAIVAYNPRDLGAGAPHFRAATLRPDVTLRRGDKVNLTGLTDGLLPTSRKSVVTNPNLAANVSSADAPRYRAMNMELIELDTDFGASFAGVLADDRGGVLALWSSFSMQVKYSDSNEDQQFVRGMPIYPVAEVLPALINGPGPATSSLPSRIHGCGVPLLRTLGVEMSRTLLSQARSFGLSEQWVKKLLEKDSLRRQVLRVKGCLAGSAAEKALQQGDMILAINGEPVTCYRDVEVACSGLEGSGGETLPLTVLRQGAELQVTVGTELENGLGTTRMVHWAGAALQEPHRAVKSLNFMPKEGNGVYISRWCHGSPVHRYALYALQWILEVNGRPTPNLDAFLAAVNKVKHGAFVRLKTVHLNGKPKVLSLKQDLHYWPTWELKLDPESGRWVRRVIKAHA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATGLAAQLKRLAAPQTSAPVDARRTASILFDAKEAASKDREVIYDIGVSGLEELTQMHGAFAQFEDTLFDKRAMDLQRSVENREVNEQLDGNIRRFFYHLSPYFMLQPAHKCLEWLIRRFEIHKYNRELFVHLILPFHETRIFVRCVQTMQIEEVNDRLAFLAAVGKSGVPPAKRTIIDHCVSHPGFLQQYGSFLTGAVEELAGRANALQATFAFYCTTALGMLHSAETVSENHVTAVLHTVGKGLASRAIDFAAGSFMIVGQLVMKASLAQLTVDYLARRVIAVQLPALTAEATMLLVLIFQTQHERLATLSRELMGEIRRCKWLAPTLCTVKADGVDVLVLYRKLLEKCLNEICCTKGALKLYSGFCEQLMLEIQLTEVEAEVIVQCVLDSYFHKDVPEKKAVAANSDDTIELDSEEEDDFVSRDQHVTQWYSEYLKSFERQYPGAFDKVVKRIMKGQEQYSPKKRNALRNVLGFLLQASYDENETNVFESLFHYDADRRAHAVQYLVENLRAMKLKSTGQVDLLRDSVRERLADSSCEVIEELLKIDPQELIVVVGTDELIGRLSQLVLKCAANQTRWAKVTPRVIELLTDRVVYGRGNVNQIIIALYPLLFPIGNDPVGQRNAKALLSTSFAKQYLVARFYGNEENCELMLSTLLEAGQCTNPVQVCFNILLLSSALPTPCTVGQADRVLDYAVRQLQNHRFRYAPTSDIQCLQDNQLPQDLLTVPIRYILERVQFEPIGAMNFGRQCVSLKLRLRIFAVLLEQYCTIDPQHGAVRSIFGELLKSYLSRLYPQLVDRIEFLSHFYTAHLIEPGSKDDADNFLINAKLQIRCQRLLNTLLEQVSQEESGCTVTESALINVLLSLTSGSAVVRECTMRTLQLIVGLRKRNGLSKAFNGFVKRMYKRREELTMDGEQLALVVFAIFSLEEEEGDGHPLQPVMESFVARIVDPSTPTYIVCGIVDLLKLLDDPHVLLSCASKGVSIIERVNAAASQPVFDAYESRVVQLLLTRFNLDIVAHLPGSAICQRLVTLAIRCDKPLCLPSERKLCTPAIAMIEALAGEVFETLPKAYAQEVLQCVVAATTLSEHPETNAATGKLFKSSAIDAEVVVDMLCAMYDGRARDDATGKQPGKPGRKSIAIAPSERVLGSTVWKCGVTLLEHLQNKRKLANAQLLVPKLFECLKYCLDFEEQSAVEYVKQIVLALLLHCIQKVEHESPAGGPAPFANASGTFKVEQIVQCIRGTQNPQTHHHALLLLAHVARYVPDQVLHNMMEIFTFVGSSIVRQDDAYSFQIISKIIETIIPTIALGGGGGGGGGEGAAASAAPTAAQMEQVVPILKIFSDIILDVPEHRRILLYVKLLQTLGPAEYLWVFLGVLIESDVMKGGQKAERRNPAKSRADAELAGSELSKRMEVALLIAREFEPTVIIQTCTYLVDYLRDLPMEIEKRKSDLGPMELDVVDGSIFNVKTHTGRQLKHFKYSLVQFVGGLLSTVFVINKIAQLNEEETLGMKKYYQNLIVGILTYVNAVSKMLDKLKEDGSDEKIPLYWRAMLNNCYDILESTISLLSADTLIIVVHGLLKHRFLMVRRKVIELLNNKLQYKQDYFNDSHYPGLLKLFDPLVELVQGLYEEQHVVGTAFERMVIVQLSYIAVRHLSKILTQYDTKKVQSVLAALMEELHGYKRNPNTQILSSLILCIGELCSHLGPYSINFLPRFMPMVSKFLHAQLQSGEPFDILTSSIVLLTVKIVDTLARFISPYLRSMLVGLARLYAMIEQKKDPRLGNMLSRLVLIWDSLTTTITPRVLLPAIEECYHTLIGEGELSAIGPLMGLLSTMFGKMKSSSFDAIRSEVTELFLTALQFRCYNSATDTYTLDAIDAAEAHVIKAFVVLILKLSESTFRPLFYQVFEWSIRESSSNDRAITFFNLCCHVAEALKSLFVLFASDLVAIAVKLLNATNSAKVGEHGGDGGDDAVGELHFEVESKNVTLLRYVLKTLYSIVLYDNQNFINAVRFDMLLGPVSDHLENGLIVRVPEVRTLVIDCLAQMAVAVMDDSLWRQLNYQVLMKTRNNDAQVRLFALEACTEIARKLGESYAPLLPETIPFLAELMEDDNEDVEKAVHHSCREIGRATGEDLQKYF
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSRRRSGKAKPKKQKQDQAIKWRRNQKKSEQPTEIVKKEKCEEGEKTRFFGCYLLTSLSPRFKGHSYIGFTVNPKRRIRQHNGEITSGAFRTKKKRPWEMVLCIHGFPTNVAALQFEWAWQHPRESVAVREAAASFKTLGGLANKIKLALTMLTLHSWQSMNLRVSFFSTKYMKHAAGCPSLPPHMKLHFCSMDELPCYEDIDQTYGCEDGDDLDSTNSEVMASCSDDRIESLSDGSMEMNPSSIHVQNFTVQKSADNILEEDFIGIGGPLENESSLMMGALEDHIQPLHQFPVDVSGSTLNTSNEQLRHCEEIWTEDVRASFPELEERIQYIGGIYASENEVFPVLEENYSSGDLPADVTAHVENDLSECSTPGKEIRPKKLRGSSPIIEERIQPFQQAGSSEREQSSMVDFAKKDEITCIVIDDISDKPTRVQSPIRFANIVWPFSNEGIEVIELCTPSPDYRIAVGSKKRRAASDIIDLTGSPCFIQL
The following text describes a protein:
Function:
Required for normal beta-1,6-glucan synthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MKLALLSLIGTALATPAVMLSHKELTAFEKYTNKQTSNSISAVELDRVARKLMHDCSANTYVVVNQPGLKAKDFQTESAFPFLKKLLERTSTMYTVPYADGGIELGKLANSVAKQCGAVKIDVNLDNNITPLEEYMDTTKRVIEINFEPLPNTYVSRLAALAANDEMLEKIVRATPSPFIALILTSQKGEEGDFETRNPDFKIFPGVARAKTVPGAKDKYKYHMELQNVPVDEKKLTAEALLKVKTPPTHAPEVRQTGDGELVDDKLLLMIVGSVVAILLSLLVFNGLMAAKPDVVKVDKTDAKVEKAVKKEVQKKERLVNGRVEQLKRETR
The following text describes a protein:
Function:
Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose.
Miscellaneous:
MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD medium.
Sequence:
MSNITYVKGNILKPKSYARILIHSCNCNGSWGGGIAYQLALRYPKAEKDYVEVCEKYGSNLLGKCILLPSYENSDLLICCLFTSSFGGSSHGEKQSILNYTKLALDKLKTFREAKDKTRTSEDSIGDYLNGHIKYPIGEYKLEMPQINSGIFGVPWKETERVLEEFSGDMSFTVYQL
The following text describes a protein:
Function:
Transports electrons between flavodoxin or ferredoxin and NADPH. Reduces flavodoxin 1, flavodoxin 2 and ferredoxin, ferredoxin being the kinetically and thermodynamically preferred partner. Required for the activation of several enzymes such as pyruvate formate-lyase, anaerobic ribonucleotide reductase and cobalamin-dependent methionine synthase.
Subcellular Localization:
Cytoplasm.
Sequence:
MADWVTGKVTKVQNWTDALFSLTVHAPVLPFTAGQFTKLGLEIDGERVQRAYSYVNSPDNPDLEFYLVTVPDGKLSPRLAALKPGDEVQVVSEAAGFFVLDEVPHCETLWMLATGTAIGPYLSILQLGKDLDRFKNLVLVHAARYAADLSYLPLMQELEKRYEGKLRIQTVVSRETAAGSLTGRIPALIESGELESTIGLPMNKETSHVMLCGNPQMVRDTQQLLKETRQMTKHLRRRPGHMTAEHYW
The following text describes a protein:
Function:
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear.
Sequence:
MSEVGICKSLAGGGSLLAPKEGGGWHHPVEREEHPVGDANTVSEGHDKESAYQNPGQLVKAEAQEDDWKELGKKRHRRLRSKNKRRWKPYDKLTWEEKKELEERQSQRASRIRAEMIAKGQPVAPYNTTQFLMEDHDQEEPDLCPPPRKSSAALPLALNNSSYKGDSTDDDLEEEEDEAGSDGMGGYDGEDFLQKDFSETYERYHAESLQDMSKQDLIKEYLELEKCLSRMEEENNHLRVQSLASAPAADHRDTRIQELQVELEKLKEENQRLLQEGKQVAADSP
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTAAPASPQQMRDRLLQAIDSQSNIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQVPSPLPLAQPPTPPVRRLDLLPNAESPVHWPEQPEGHPRLTGPACRAGLSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQLPRTELEQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWPGVNGCEDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
The following text describes a protein:
Function:
Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
WAKAGLEDRRLPMAYLSVSLLLLAATVLLSEVTRRTATRLLAGKDYAVYVVEIISTFQLCACTHELKLVGEVGRVEPQIGLTLTYLITVVHVLTFHGAFCNPSGALEQFYRGNLTEKSVVARIACQFLAASIARLLLPHIWSLGLSDWHLQHELSGFQCGSPIRDTLLKAAGVELCCAFVMQSTVTHLHKLDGKYHIHVIAAVITLLVYAGGHVSGAVFNPALAFSTCFHCSGNTLMEYAFVYWLGPVLGTASSVLLFDKVIPLLHGNGGTQKMMEFPRTQTKKIQ
The following text describes a protein:
Function:
Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
Sequence:
MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKSPELPEPSVRMKDSSVQEATSTSDILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSDSGSSSTSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRRRRRSPSPPPARRRRSPSPAPPPPPPPPPRRRRSPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSPPVTKRRSPSLSSKHRKGSSPGRSTREARSPQPNKRHSPSPRPRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSPSPARNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAATPSAQEEPAAAPEPRKVFTRLCLPCEKWLCFLATSCFSVVF
The following text describes a protein:
Function:
Potential transporter for phosphate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDLLVIAIILAGLYMAWNIGANDLANAMGTSVGTGALTIKQVIVIAAVFEFLGAVFFGKRVTSTIAKGIVPIDMISSIHPDIVVLGMLAAILAASFWVTLATFYNLPVSTSHSIVGSVLGFGLVAAYNGSISFSDIHWGELTRIIASWFISPVLGAFLAFLIFTMIRSLYLHRASDLPSVEKKFIFLQLITACYIAFAHGSNDVANAVGPLSAALNVMGVTGTEIPIWVLVMGGLGMVIGMATWGYKVVETIGSKITELTPTRGFSAQFATASVVLLHSYSSLPISTTHTLVGSVIGVGLAGGIAAVDLGVIWRIISSWIATVPIAALTSAIIFVGLEVIFL
The following text describes a protein:
Function:
Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives.
Subcellular Localization:
Cytoplasm.
Sequence:
MVTEMSHAESIKRVVDQKLSSHEGFESHMFKIGSYNEAVGESSPFALPYDDSTMALLILSTPDMFDVAFRKWVVQKTMDFGSFDEVCEMVSSPIQSFLEDRLEIMSEKLRKVEENFEILHDYSMTPQRRPKILMQTCGHVAGAAFYYQPCHFQEDGVTWPPAGRMGPNLKFIGLSLHPIYGGHFAFRSVLIFPNVKIPEFCEKEPRPILTASEDVRTALEKFNYNWKDSGFRDFGNPTRRYSTTQMEFFGRPVAERWEVLRPWVDGGAKNID
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MEIAVKTLSLSLNPKIISYKQVEDVFIPNLSCNRACFPPQKRYRALKYQGRERHVHLLTVHAVSSDLEDVGVSSQFEDFNVTTASINENRELKISVEISGAKTRAIFDDVFDKMVAAAQPIPGFRRVKGGKTPNIPRDILLEVLGASKVYKQVITKVINSTVAEYVEKQRLHRSRSGHLSECSCKHPDYEESLAVGKDLRVEQSFEDLEEMFEPDEKFRFDAVIKLQETN
The following text describes a protein:
Function:
Vesicle trafficking protein that functions in the secretory pathway.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein.
Sequence:
MNDLLKGSLEFSRDRSNRSDIESGHGPGNSGDLGLSGFFKKVQEIEKQYEKLDKHLNKLQGAHEETKAVTKAPAMKSIKQRMERDVDEVGRISRFIKGKIEELDRENLENRTKPGCGKGTGVDRTRTATTIAVKKKFKDKISEFQTLRQNIQQEYREVVERRVFTVTGQRADEEAIDRLIETGDSEQIFQKAIREQGRGQIMDTLAEIQERHDAVRDLEKKLLDLQQVFLDMAVLVDAQGEMLDNIENMVSSAVDHVQSGNNQLTKAVKSQKSSRKWMCIAILILLIIIIITVISVLKPWTQKNGA
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNDITAAASVIAAALAVGLAAIGPGIGQGNAASKAAEGIARQPEAEGKIRGTLLLSLAFMESLTIYGLLVSIVLLFANPFRG
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MLLSKNSALESKDNEIFEVEESIAIQSELIKTMATVVNSKAYVNERNQMVPEARCRKQANYHVEQNNKIVDEELSDWESKFFEVDMDYLHELFMAANYLEIESLLNGVTKRVGDFIKACKNVEVIRQTFGINNDFAAQQEEEIRKLNSWNHI
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Subcellular Localization:
Nucleus.
Sequence:
MGKQKQQVISRFFAPKEALTSTPPSKKLKSCSSSPSPGNAEKTLISAKTVANSSKPIVSSKAIATPPKTLISPAKSDSKSSLPAFNPSLHRKFLEKLLNPPSSNRTLSNHKLASNDQKFTPLEQQVLSLKSQYPDVLLMVEVGYKFRFFGEDAETAARALGIYCHQDHNFMTASIPSFRLHVHVRRLVGLGFKVGVVKQTETAAIKAHGSNKVGPFSRGLSALYTKATIEAAGDLGGELGDACYNSSNYVMCVVEKSELGFVEEGFDTRIGILAVEISTGDVIFGEFKDGVMRAQLEAVLLSVGPAELLLGSPLSAQTEKILLGYAGPTSNVRVERASRECFNDGGALAEVMSLYEKLVEDGSTVKQCEQKEDIKPNEKLSLGVEGIMAMPELPVQALALVLRYLKQFELERILCLATFRPLSSSIEMTLSSNILQQLEVLRNNSDGSEIGSLIKLMDNTLTAFGSRLLKHWLTHPLRDRISILARLDAVSEIADSIRVGEGAHNAADNESTDCGAKVVRVELYNLLSSVLTTLGRSPDVQRGIARIFHRTATPKEFIAVIHALLCASKQLQRLDLGEESNEGPTSPRSDLLRRLILTASSLKVTSHAAKLLSALNKDAADLGDINNLFIASNDKFQEVARGCTAVQAAEEKLDALIGQYRKILGIRNLEFLSVSGSTHLIELASEVRVPQNWVKVNSTKKTIRYHPPEVLTALDGLALAKEELTIICKTTWESFLAGFGSYHADFQASVQALAALDCLLSLAILSRNQNYVRPVFLEENEPAQIQIQSGRHPVLESILQESFVPNDTNLHVEREYCQIVTGPNMGGKSCYIRQVALIAIMAQVGSFVPASSARLHVLDAIYTRMGASDSIQHGSSTFFEELSETSSILHSCSSRSLVIIDELGRGTSTHDGVAIAYATLHYLLKEKKCLVLFVTHYPKIIDIKYKFPGSVGPYHVSYLTTKTTENGENTGHGNVTFLYKVVPGGTDKSFGLNVAGLAQLPASCIARAAVMAAKLESDVCSRLKNRLSGNIQRVSVIDHSPFDEHGVREKEYLEVFSLLWNSLLDSDPSNCLHSLKDIQKHALEIFSSENGQ