lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Inhibits the protease activity of CAPN3. May play a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SLF2 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication.
Subcellular Localization:
Nucleus, PML body.
Sequence:
MEDFIVISDDSGSESSAGTRSGRARRLRRALSRTPGALPRRTVDFIDLTRENRARTKDRNGLCVIDLTRNEEENRPIATLDLTLEPVASSQKEPTSLQTCTSLSGKEVMEAHEDRGSQPAAQRIINNDPVDLDLLEENLFEGSRPPTSISQDSVYPPEPNCSSITYKGDLSFLTSLQLSSDVSSFSSTSNQRASLPCPQQDVPCQSQGLLCPLQALSCPQTASPCPPRASSCPPQALSCPPQALSCPSQTLQCQLQALPQPPQEVPCSTQNVPCPQQNMPSTPQGLSWHPRHTLYPYQDTLGLPQDVPGRPQNMSYPQDVTQLQDMPWSLHDMPLSLQDVLQSLQDVPPLLGDVPPSPEVMQLPGYVTQTSRDVIQSPAGVTQSLGSMMQSPGSVTQSLRSVMQSSGSVTQSLRSVMQSSGSVTQSLRSVMQSSGSVMQSPGGVTQSLRSVTQSPGGVMQSPGGVMQSPRDVMQSPRDVMQSPRDVMQSPRGVTQSLGSMMQSPGGVMQSLRSVMQSSGGVTQSLRSVMQSPGGVMQSPGGVTQSPRGMIKSPGMMLSPGDVIQSLNSVPQSSRDRMQSAGHVPSASGDAIQSPGGMSPTSRDRMQSPGGVSLATEDSIQLPGGVPLSSDVIQSQGGVPLSSKDRMQSPGGVPPSSGDMIQSQGGVPQSLGDAIQSAGGVPQSSGDAIQSPGGVSLATGDSIQLPGGVPLSSGDVIQSQGGVPRSSRDRMQSPGGVPPSSGGVIQSPGGVSPASGDAIQSPGSVLPASGDAIQSAGGVLLASGDAIQSPRSVPQSPSGTLRSPGNMSESLGDTPNLSGDVSNSPQALLDLARDRPKSSPNDVQNRDTPMDISASSSSSCSANPQSRQSEFKLDKVPWLTITDSSARREKSLPQLANPGSAQIQGQIPQVGVYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRESKGQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIVQKILLSGSETVDVLKEAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDDFQQILRRQRQHLQQSIANTVLSCDKQPHNVRDVIKWLVKAVTENELTPPQDETQTSPRTGVLKTSSDHLSPRPNQNKNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIPERSQREMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLSLAQTLYFLNNSTSLLKCQSDKTQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVLDVEKQIEAFRSRLVHILGEPLVPQLQDKVHLLKLLLFYAADLNPDTEPASEH
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSAAATMPMPREASNYDEISMQQSMLFSDSLKDLKNLRTQLYSAAEYFELSYTNDEQKQIVVETLKDYAIKALVNTVDHLGSVTYKVNDFVDEKVDEVAGTELRVSCIEQRLRMCQEYMDHEGRSQQSLVIDTPKFHKRYFLPSGEIKRGGNLAKLKNVEGSFDGEDDWNQFRNAVRATIRETPPPPVRKPILQSPSQRKPQRSATFSFSSIATAPKKEQDKRAVSPHRFPLLRSGSVAIRPSSISRPTTPSKSRAVTPTPKRYPSEPRRSASVRVAFEKEAQKEPEHQQQPSKSKRLLKALLSRRKTKKDDTLYTYLDEY
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MDSPLSSVRVQPALQSPSRPHTVKEVPPSIAKTTDLNLFFPKTKKNKKSLLIDPFRKPACLPSPASSLAADLSMNMCIDKSPSLPTPRRSLFRSLSCSNDTPVPVEKHSIVDESPSDEAIVSTFLRRSRSNNFPDVEEYAEMLSPTQPMSRAASLFVPKGPKVYSKLPPTSSARTCTVEQLPYRRPIISRLPTGLSKATRPLLRSRSTSSSSIQKRRALSSHNPRQVALAIQRTCSESSTTTVESLITDDGTITPSVEADDPLDMDSDLSPCLIELPGKRGGMDSAWMDAQPEDSDMLEDLFQASPVRPHRLAHSTSLHDDCVPDSPLAPGALPYAREDANDYDDQGTPLMQRTRSMFNKSPSRLGVWNQQPLLQMTPKPYSDTPLGVSTRVEDYKLPCFSVKEDSLKRINQETLLSLLDGQYKDVFDQFVIIDCRFEYEYSGGHIGSAINLNTKQAIYDHFFTNPRKSRVVLIFHCEHSAHRAPRLALHLRNTDRQQNCHRYPYLYYPDVYILHGGYKSFFEKNKDRCQPANYVSMNDASHVMTCTKAMNNFKRNSTFLRTKSYTFGQHHTFSSVEDSPTASHSLSRRRRY
The following text describes a protein:
Function:
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Sequence:
MASDSIQCVSNGNDNAQSIPERSYQVVVAATPDMGIGKEGKLPWRLPGDLKFFKEITATTSDPNKKNAVLMGRKTWESIPPQFRPLPGRLNVVLTRSGSSDSNSDESVVFCGSMSSALKLLAGPPYSFNIEKVFLIGGGQILREAFNALQCDAIHITELKSFIECDTFIPPIDMSVYQPWYSSSVIEENGIKYCFATYVRLKNSIKGPVSTSHSNRLKLSDFTFLPKHIFDKHEEFLYLRLVQDIISNGNNKDDRTGTGTLSKFGCQIRFNLRKSFPLLTTKRVFWRGVVEELLWFISGSTNAKILQEKGIHIWDGNASRDFLDSIGLTEREEGDLGPVYGFQWRHFGARYTNMHDDYTGQGIDQLMDVIDKIKNKPDDRRIILSAWNPSDLKLMALPPCHMSAQFYVANGELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCGLVPGDFIHVFGDAHVYKTHVGPLQEQLKKLPRPFPILRINTEKKDIDSFVAGDFELVNYEPHQKLEMKMAV
The following text describes a protein:
Function:
Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKLSNVFLAAVVILTCVCVFQITAVPFIQQVQDEHHVESEELQENQHLTEAEHRQTDPLVLFRTKRQSHLSLCRFCCKCCRNKGCGYCCKF
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MMGCVEEKVKAGGLSSGARTSLLEEMKFLKEMQDQSGARKAINSELWHACAGPLASLPQVGSLVYYFPQGHSEQVAASTKRTVTSQIPNYPNLPSQLMCQVQNVTLHADKDTDEIYAQMSLQPVTSEKDVFPVPDFGLKPSKHPNEFFCKTLTASDTSTHGGFSVPRRAAEKLFPPLDYTMQPPTQELVVRDLHDNTWTFRHIYRGQPKRHLLTTGWSLFVGAKRLKAGDAVLFIRDEKSQLLVGVRRANRQQTTLPSSVLSADSMHIGVLAAAAHAAADRCPFTIFYNPRFTESAIFHLLVFSLFFLPHSFILYLLLYPIIVFLICRACPSEFIIHLARFRKSVYGTQLSVGMRFGMMFETEESGKRRYMGTIVGISDFDPLRWPGSKWRNLQVEWDEPGCCDKQNRVSPWEVETPESIFIFPSLTSGLKRPLHSGFFGTETEWGHLVKRPPVQVPENGNGNLPYSISNICSEKLINMLLKPQIINHPGNFLSTQQEYATKVEPLQDVKTMLGTMNQKSQSISSEGTSPVPPQSCLDQQDVVNSNSSLKAIASGKLNPLPKFENQTLAGANTEKPNFEPEISAEELSQVTSTGECNEQKMAAGPMSLQNPVNQPTFFNQSQESIQAQTSLWPMQPQLESLIYHTEQLDVPQSDSSNLNGFLPSPDLDEWKFYPSCQPLSGMFRSPGPLSVFGLQDPSTLFPEAVNPPLPSMGQEIWDHQLNNLNSLSQAEQLSSFSQQDPCNVNCTSNSIVLRDMSDESYNQSGIYSCPNIDVNNGRSAMVDPSVSSTIVDDLCMLKSTDFLNPPDYLIGNFSSGQDVQSQITSVSLGDSQALSRKDLPDNSGGTSSSNIDFDEGSLLQNNSWQQVVLPVRTYTKVQKKGSVGRSIDVTGFKNYDELCAAIECMFGLEGLLNDPRGSGWKLVYVDYENDVLLVGDDPWEQFVRCVRCIKILSPSEVQKMSEEGMKLLNSAAMQGV
The following text describes a protein:
Function:
Endothelial orphan receptor that acts as a key regulator of angiogenesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKRLPLLVVFSTLLNCSYTQNCTKTPCLPNAKCEIRNGIEACYCNMGFSGNGVTICEDDNECGNLTQSCGENANCTNTEGSYYCMCVPGFRSSSNQDRFITNDGTVCIENVNANCHLDNVCIAANINKTLTKIRSIKEPVALLQEVYRNSVTDLSPTDIITYIEILAESSSLLGYKNNTVSAKDTLSNSTLTEFVKTVNNFVQRDTLVVWDKLSVNHRRTHLTKLMHTVEQATLRISQSFQKTTEFDTNSTDIALKVFFFDSYNMKRIHPHMNMDGDYINIFPKRKAAYDSNGNVAVAFLYYKSIGPLLSSSDNFLLKPQNYDNSEEEERIISSVISVSMSSNPPTLYELEKITFTLSHRKVTDRYKSLCAFWNYSPDTMNGSWSSEGCELTYSNETHTSCRCNHLTHFAILMSSGPSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCFENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLSC
The following text describes a protein:
Function:
Binds the 3'-UTR of mitochondrial mRNAs (By similarity). Involved in the processing or stability of mitochondrial mRNAs (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MFRLIASGAQQGLRPSLISKVKPPTTTTTTSTTSKFTSTTQHFPFENNNLLGYQVRNNSSQAGVASEPKISLPETDVYQQKLLKYNIKKHEPYHLKFNPKTKNQRNNDSASSFSIDEFSQLLQDETFRNQLNEKHLFVYASNLYSGTINSRRARLNKSKNRDKDQRSAFREDMTLQSAVLNLTEIISTGELNSVLSARTLFKVFGTLLQFKLNDEIVNLWETGVNSDVGKLYLAHEVLSIVIQVGHETRRFNYDEIKQIYEMSVKEDKTVHPYLSDRMGQVAVMEGDYVTALDALESLMNLYEQNPNEKSVLGALAQIHLSFIGHSKDLAIAERFFEKGLQKEGLPYSVIMKAPYMTSFLSNCIAGGYSMEEVIDFWRRISKHYLEQDFDLISSQSTLHAGFFKSFFEKYPEPSKEAIDLLNLAIESAPKVNEVLLNTLISNLPWADKEIFNKLLNLYQEKNVTKSIVSHRIILKQSKQIEYTNEEILQLWNELLGKLDEAGYTYIANADWSALRASTMFSGKFSYQRTGLYLSVLGKYKDYMQNNFAAIQFLRNWVRDANAYRLISKITLEENPQFDGAIKVDIPEFDSLRPNINYREVTKQVTDADPRLLE
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MECSRGRRRWRWCGRSMLKLAGLCCFAVAIVICFCGVRSWACSASACRGRSTVLLRSEPWGRGRAAASCDNQGCYINTGVQGQGQWRRLLAEGPGSYPPRCTSKCGDCSPCYPVHVAVPPGVPVTTEYYPEAWRCKCGNRLYMP
The following text describes a protein:
Function:
Transcription factor involved in the regulation of fruit patterning. Promotes replum development by down-regulating JAG and YAB1/FIL genes activity in medial tissues. Seems to inhibit fruit dehiscence, maybe by controlling valve margin lignification. Promotes callus formation at wound sites. Is required for the formation of highly vacuolated large cells in callus and for the establishment of organ reconnection. Targets directly genes involved in stress-induced cellular reprogramming, and cell wall modifier genes.
Subcellular Localization:
Nucleus.
Sequence:
MMEWDNQLQPNNHHSSNLQGIDVNGGSGAGGGMYVKVMTDEQYETLRKQIAIYGTICERLVEMHKTLTAQQDLAGGRMGGLYADPMMSSLGHKMTARQRWTPTPVQLQILERIFDQGTGTPSKQKIKDITEELSQHGQIAEQNVYNWFQNRRARSKRKQHGGGSSGNNNGESEVETEVEALNEKRVVRPESLLGLPDGNSNNNGLGTTTATTTAPRPEDLCFQSPEISSDLHLLDVLSNPRDEHLVGKMGLAESYNLYDHVEDYGMSG
The following text describes a protein:
Function:
Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation.
Miscellaneous:
MISCELLANEOUS: The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth; MISCELLANEOUS: HprSR and CusSR form a unique regulation system, where both two-component systems recognize and regulate the same set of genes, but under different environmental conditions. HprSR plays a role in H(2)O(2) response regulation, while CusSR plays a role in Cu(2+) response regulation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVSKPFQRPFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSQGKTVYHSPGAPDIREFTRDAIPDKDAQGGEVYLLSGPTMMMPGHGHGHMEHSNWRMINLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVITLPA
The following text describes a protein:
Function:
Suppresses apoptosis in host cell to promote the viral replication. Has the ability to potentially bind to all the members of the proapoptotic Bcl-2 family. Inhibits autophagy by interacting with host Beclin 1 (BECN1).
Subcellular Localization:
Host mitochondrion. Host endoplasmic reticulum.
Sequence:
MEGEELIYHNIINEILVGYIKYYINDISEHELSPYQQQIKKILTYYDECLNKQVTITFSLTSVQEIKTQFTGVVTELFKDLINWGRICGFIVFSAKMAKYCKDANNHLESTVITTAYNFMKHNLLPWMISHGGQEEFLAFSLHSDMYSVIFNIKYFLSKFCNHMFFRSCVQLLRNCNLI
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MNILVKVHISSSLWIKLWILIGNWIWLCSPLGDSSVLLCIGDMNASSERDYEEFEMLLGEIPNATLVAPQIQCPANSKRKLENSLMSSNSDSFANVYHSSQSPKQVSPFYNSMAYDRSPQLNTSKHPYDQKPHSEDSSSNGQNDHSKPKSSIDQNGGSLHNQQDLTSGFSNLRLKNDNKSMQNYSFLSDGQLQRCLGDPHLAIPMPSSPNHINCMSLVTPSLEPVNFSRPAVSSQLTGETNGNESDRSLKVNGVNGNKGNEQLTLDEFSIGERQQGPPIFSGALPFHHGARTTPFVPNVPLSGLEGFQQQYYMDAHSSPYIQPQSPYDHPNAAMQQLNRHQIAWRHLEEERVTRMQQQVAYLQQLQNQGTNQGSLNLDMGSFARNTRQSFCDMTLSPQMEHSNQSPFWGNGVVQGGVSPTDFTLMGGSHCRYYSQGLCGRGETCSFTHTQKQSQGSGRGCVSCALFPKDFQGVSMMDKEEKHLLPEKILTRSHGVNSIRAIKQNALMGKSSIMATDPWANAKAFANGVCLSTSISNGLSFQLDGQCPRGSSPEIVDHGLSLRYQNQLKFSSLDEVEGKILLVAKDQQGCRLLQKRFVEGTLEDVNKIFVEIIDHILELMVDPFGNYLVQKLLEVCNEDQRTAIVHRITAGEHIITTISVNMHGTRALQKVIETLRTREQISLFVSSIKPCLLNLINDLNGNHVVQRCLTVLSTPDSQFIFDTIAVHCKDISTHRHGCCVIQKSLSPEFGERRYPVVQRVAAHALELSQDAYGNYVVQCVLGLEIPWATLLLLEKLRGHLAMLSKQKFSSNVVEKCFSHVQDEQKRSLVRELLKHSPLLELLQDPYGNYVIQAALKFANVSLRDEILNAIKLHIPMLRSNPFGKRILASINSKK
The following text describes a protein:
Function:
Catalyzes the biosynthesis of ethanolamine from serine. Highly specific for L-serine and does not attack D-serine, L-phosphoserine, phosphatidylserine, L-histidine L-glutamate L-tyrosine or L-tryptophan. Decarboxylation of free serine is the major source of ethanolamine production in plants and ethanolamine metabolism is crucial for the synthesis of choline, phosphatidylethanolamine (PE) and phosphatidylcholine (PC), and thus for plant growth.
Miscellaneous:
MISCELLANEOUS: The mutant phenotype can be rescue by exogenous application of ethanolamine.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MVGSLESDQTLSMATLIEKLDILSDDFDPTAVVTEPLPPPVTNGIGADKGGGGGEREMVLGRNIHTTSLAVTEPEVNDEFTGDKEAYMASVLARYRKTLVERTKNHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRPFEVGVLDWFARLWEIERDDYWGYITNCGTEGNLHGILVGREMFPDGILYASRESHYSVFKAARMYRMECEKVDTLMSGEIDCDDLRKKLLANKDKPAILNVNIGTTVKGAVDDLDLVIKTLEECGFSHDRFYIHCDGALFGLMMPFVKRAPKVTFNKPIGSVSVSGHKFVGCPMPCGVQITRMEHIKVLSSNVEYLASRDATIMGSRNGHAPLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFERPKDEEFVRRWQLACQGDIAHVVVMPSVTIEKLDNFLKDLVKHRLIWYEDGSQPPCLASEVGTNNCICPAHK
The following text describes a protein:
Function:
Modulates phytochrome-mediated control of hypocotyl growth orientation. Involved in PHYA and PHYB signaling. Acts as an inhibitor of asymmetric growth. Not involved in the control of leaf flattening.
Miscellaneous:
MISCELLANEOUS: PKS1, PKS2 and/or PKS4 are essential for phototropism but not for inhibition of gravitropism under long-term blue light irradiation.
Sequence:
MAQTTVTVVATKRDALDPYIKILQNRSNDIDVSFSSYLKPDNNEQQQKENEDTELSIFEARSYFSENGSNDSRCQTRNLSGPRFSSVASAKVSSFTVGQTASSEASWNSQTGLLSNKNRQGSDRDGRRSSKKGPRWFFRRRACPCSSSKSVQVQESKPRIAVPKTGSDRIVSNRIVHSHQTISSPEPIRLTIPSNTVTRSIDYTANKEARAPVSNFSFPTLNETSQLSENPKNPVLNHIKPVRIEPALLPIKPVLNPTSPKGVIIDEEATSDASSDLFEIESFSTQTAARPWAPPVRDSMEETVSEYGYEPSEASVTWSVMTAEPASAVAANFSRIALSSSSTAFSGYDKKRTGLLNCHCEKAVMVNGDKRLVQPVKSVGVQNDVAGKVLCNNGSSKLSVTSRPRQ
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Reduces preferentially hydrogen peroxide rather than alkyl peroxides. May be involved in mitochondrial redox homeostasis.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MASTILKRVTSSAIKSRLESLLTGASRRSYASVAAGTDIVNAAPGVCLQKARSWDEGVSSNFSTTPLKDIFTGKKVVVFGLPGAYTGVCSQQHVPSYKKNVDKFKAKGIDSVICVAVNDPYTMNAWADKLQAKDAIEFYGDFDGSFHKSLELEKDLSAALLGPRSERWSAYVVDGKVKALNVEEAPSDFKVSGAEVILEQI
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLLPAGGGGGAPRGAPGLAVLLLGLSWYCLAASQLRYSVPEELEHGAFVANLAEDLGLDVAALSARRLRLVSRAGAKQHLEVNLENGILFVNEKVDREELCGAGEGGEGGEGGERGQPCLLRLQLVVESPLELFRVEVEVLDINDNAPRFPWPEFVLEVAESALPGARFPLESAHDPDVGPNALRTYRLGPNEGFFSLAVQARRDGSKFAELVLERALDREARRSHRLLLTALDGGQPERSGTARVTVAVLDANDNVPVFDRPSYSASLPEDAPPGTLVVRLNASDADEGANGEVEYALSGHAPPAARELFSVEPRGGRVRLRAPLDYERAPLHELFVQAKDRGPSAVAVHCRVLVQLLDVNDNAPEVTLTSLAAPVMEDAPPGTVVAVISVRDRDSGDNGRVSCEIPSGLPFRLRPSFPDYYTLETAAELDREAVAEYNVTLTARDAGSPALSTRRTLTVPVSDVNDNAPRFLQPSYRVYVAENNAPGASLCSVSARDPDAQQNGYLSYALAEGRIRGMPVGTYLSVNADSGHVYALRSLDYEQLRDFRVQVVAQDAGFPPRSGNATLHVFVLDQNDNAPVIVAPTPRNNASSSSEVEVEIPRSAEAGFLVGKVSARDADAGQNARLSFQLVGGGGEGLFGVAPHSGEIRTLRGFREGDPARHRLLIQVRDHGQPPLSTSVALLLSLVDGDAEETGHEQRDEPPEAATAPPLTLYLIVSLGSVSFTFLVAIVVLAAVKCRKERLSFACALGPCGGSEEEGPAETFKGANNNQAPPPGALEEEGGTAGAPPGYCYKVCLTPESAKSDFMFLKPYSPSPPRNNNKQKLGAPEKQPPPGKGHRGAPSNHNHNSSSSSAQVKQPNTDWLPSKQATLKSSQSLEDVGGVRRGVQKDHDRLRNLVTPVSDATLLVTELQKTPGAPSSVWTPRYAPMYSQHISPLDYQHNVYIPGTPTMPSSKDGPLFLEQEAKNSFSTFGKRKKMTTYCDIHDNMIINNNLK
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRNLVSLNKGSLQPSSEAHPNLGLYASCFDTLSDSVTCVLGAADVGAIVVHQYMKSGAVRELASFFTQDYEDELVSFAHFADVNQLVFVFAHGDIMMATYGDEGAGLDATVVEIVGSIEDGIAAAEWSHDEETLALVTGGRSVVLLSRQFEPVADIGLELDDLKLSKNVTVGWGKKETQFRGKGARAMEREALQSLKASGLVGNELRDPTMPYMVDSGAITELDPRTVGISWRGDCEYFVVSTIETVQDPDDDSATLERRALRVYSRHGKLDSASEPVDGLEHALAWRPQGSLIASIQRKVNVPGNESLDLVFFERNGLRHGEFETRLAIDERIKSLAWNASSDILSIALEDRIQLWTSKNYHWYLKQELYTECTKFVKWHPEKDFTLMYGDGDTVNVVDFAYKMIRGPTFEPNDCGMTVVIDGRTVNITPFAMANVPPPLSYRDFDAPDNVLDAAVGLSNTVFAAVTREALVVASIESLANMKSGRHPIIASTFQKHLFATELDTIRQVAFINDSVVGILLDSGQLSRIALVNIQDPIQPELIKVVDTYTKVVLVKSSFDYSTLVYETRDGTVVQLDAEGGTVEITKFPQLVNDFCVKRILTDGKTEWQPAESKLVAFGLTSSGKLYADSVQLASAVISMDITDELLLFTSAQHYLQFVHLNTPEFKPLPTLEGDIMDERIRSIERGSILINIIPSKAAVVLQAPRGNVETIYPRIMVLAEVRKYIGLKRYKDAFVICRTHRIHLDILHDYAPDLFYANLKTFVDDIERVDYLDLFISCLVEEDVTVTKYKETLNMSTDAVFDVAPPPPTEMEEYIKKKSFNPLKSKVNKICQVLLEVLLGTAQYKAKYLQTIVTCYACQNPPKVKDALALISQLRDEEAKDSTVTYLCFLQDVLFVYKEALALYDVNMALLVAQKSQMDPREYLPFLQNLNEQEPLRRKFMIDDHLKNYEMALTHLVGIDEPTGAVSDETREYIQQHELYKKALDLYRYNTQLQNSVYAIYGAHLASKQEYNEAGIIYELLGNWEKAMEVFTMGNKWSPALAIASQHFPDRVLDIATELVDSLQYEHRYAEAAHVELKFMKNVRSAVSLYCKAYDYEQGILLCITEGTPELINELVDPALGDGFSVLAELLADCKGQINSQLRRLRELRAKKEEDPYAFYGQETEEADDVSIAASETSTKESFFTRYTGKTGGTAKTGASRRTAKNKRREERKRARGKKGTIYEEEYLVKSIGRLIDRLKQTLPDGVKLVDALLRRNMREQAYQVQKGFVSMEALLKANIVEIYNISEKDRERIDDNGNVYQLPVIPVPEIPAFPVRQIIDY
The following text describes a protein:
Function:
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MNWKQVLFLTYLMTLVLLIVLEGASTMSVGSKTVAVGSKKAATGESRKESLEKRVFIQESDASNFFKKRGKRSTKSRDELNAETRQMLAADEQRREYYEEQRNEFENFVEEERDGKSTARIGNFILENPNAKSFYPDTAACCGNACVSGKELQILGLGFSFAGSSGSGEESQMRVLP
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MAASASCLSLVVLVALATAASAQLSPTFYDTSCPRALAIIKSGVMAAVSSDPRMGASLLRLHFHDCFVQGCDASVLLSGMEQNAIPNAGSLRGFGVIDSIKTQIEAICNQTVSCADILTVAARDSVVAVRMSSNDHAHHRLDAIVNRLLRILGVQLGGPSWTVPLGRRDSTDANEAAANSDLPGFTSSRSDLELAFRNKGLLTIDMVALSGAHTIGQAQCGTFKDRIYNETNIDTAFATSLRANCPRSNGDGSLANLDTTTANTFDNAYYTNLMSQKGLLHSDQVLFNNDTTDNTVRNFASNPAAFSSAFTTAMIKMGNIAPKTGTQGQIRLSCSRVNS
The following text describes a protein:
Function:
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MEDEAALDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKAGHREKKEKERVSENYSDKSDVENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREAASLPQLVEMIVDHQIETGLLKPDLKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFTSPENGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDSPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRQDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHADCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAVFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTQFSCVCVPPNPVNISVSNDTTLAPEDLQTVSSADMYHNATFDWALLTKKECLKYEGKLVGNNCDFVPDITLMSFILFLGTYTSSMALKKFKTSRYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVYLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDSDDSDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERSPTFLERHTSC
The following text describes a protein:
Function:
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Sequence:
EHHDNIFRKVRGILNKLTPDRFDKLSLELLNVGIDSQTVLKGIIFLIIQKALNEPKYSSLYARLCQRLCEDAPNFESPKSNVTTFTKLLLNKCQDEFENRSKATEVAFERDGPLTPEEMEQSLIAKSKMLGNIKFIGELGKLEMVQEGKLPGCSSNNDASTYSGNNNVCPNPEDLECLCQILRTVGKRLDHDRAQAWMDQYFERIKTLQNMPGLPPRIKFMLQDIIELRANKWQPRKTVLPEGAPRTIQQVIRLCVCTSGIGSECMENQESIQEESGLFNTNKMPQHPNMSPSYLLSDPFFSGPPSNPQFFNDPFGGVMGTNNPGSHWLGGGTARELPPRFRKQQQQDPEMNKPSLLDRNLAKVKPSTSLEEGEHRHKPSSSSNNPMPQFHPLASASMGSRPPLLPQAGYYPPNYPPNFMRPPPFNMPPYHLPGAPSNFHPPHMVMPSRGFEGYGAGRGAPQMHLMRPNQKGHNDEEISLRPMNALAPTAAATGNVMKYPTDEDRDNMSRLIKSLHEKELFTSDQFMKSFKILLDRLSILEQDLPLAKSHLARLAAQAVCCDSVSLIDIAGPLASGNHYPMFLLCLQQLVKLESSQWLAGRFDASKINLRSMLPAELEKNDRLMEILEDRGLGFLLPLQRVQGEMWKHGVAAVGPSAAVFFKWLKENVDQKLHSDPMFVSMLVTTLIKFITMESTLKEGLDTSVAPDKQTVLKEKQLLEKYKGVLQKFLLDKIDLHVSAIYALQVFSHSMNNPKGLLLRLFSTLYDLEVIYEEAFLKWKEEVNELQPGKGQALFQVNQWLVWLEQADEDSEEED
The following text describes a protein:
Function:
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Sequence:
MQPPPPQTPPDMPLEEPSAAPGVEALRQAIVDNLRYVLGKDPSQAGAQDFLAALAHTVRDPLLHRWRNTRQAYFDCGARVVCYLASQYRPGPQLVANLVSAGLYARSVEALAGLGVRLEDLLALEREPQLGRREGSRQAASLAEALATQQMPAIGYGLRYEFGSEQVIRDGWPFERPVPWRFADDPWEIPRPEYRVEVPLGGRTEAHLDGENRYRVRWLPEGAVIGEPYDRLVPGYRTHTVNTLRLWSARASEQFDAPVANPEEYARAVEAKLDCELITRVPYPAGDGPHHQRLRLQQQYLLACCSVHDIVRLFTQTGRPLGELPERAAIHIDDSHPPIAIAEWMRILVDRHDLGWEEAWEMTGRMFSATAHTWAVETLECWPVALVERWLPRHLEILREIDRRFRLQLQALLVDEAQIARLSLFADDQVRLAHLACIACHTVVGTSESATGQLAQTVLADFHRLWPQKFQTIGAGVSTRRWLVLANPPLARLIGERIGPHWLTHPEGLDALRRHAADPDFQRSWRQIKQAHKRSLAAQLLATSGVALSSEALFDIRLEPFEGCRRQLLSALYIVTLFNRLQSEPGANIVPRAFIFSGWPRPGDPLGRLTVKLIHAVGAVVNADPIVAGRIRVVFVPEPTVALTQKIFAAADLAEQDALPGFQAGDTGSLCAALNGALLLGSPDGINLEIERTVGRERFFEFGLSTGEGQALKLTEYQPMAFYHSNPLLRQVVDQIATGYFSHGDSEQFKPIVAAMVEDDEALNLVDYQSYVDGQGSVDAAYRDLALWTRLSIESVSRLGAVCCDRTAREYCSRIWRLQPVKVHLDAYSQQVIALKGREHL
The following text describes a protein:
Function:
Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQGAYKKAAELEPDQLLAWQGLASLYEKCNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYYQEKKHVEVARTWHKLIKTRQEEGADNQELQQLWRKLTQLLAESTEDQNNETQQLLLTAFENALDLSDKIPSEDHQVLYRHFIHCLSKFPHETARLKKACEGMINIYPTIQYPLEVLCLHLIESGSLTDEGQQYCCRLVEMDSKSGPGFIGLGIKALQDKKYEDAVKNLTEGLKESPLCTTGWYHLAEAQIKMHRPKEAVLSCNQALKNIDNLGVSGGSLHQKNLCLRLKAEALIKLSDYESSVEAICALDQVSDANNIPGLLVLKSLAYLNKGSLDEASKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDPEVAEYHYQLGLTYWFMDEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYKKAFELDDTDAESGAAAVDLSVELEEMETALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESTYSVFKVAAIQQILGKYKEAIAQYQLIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIEKALEYFTWALQHQADVSCLWKLVGDACTSLYAVSPSKVNVKVLGVLLGQKEGKQVLKKNELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQAQNLTETGNNTNDLKELLEKSLHCLKKAVRLDSKNHLYWNALGVVSCHNGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLYLASENIEQAHEAFKMAQSLDPSYLMCWIGQALIAETVGSYDTMDLFRHTTELNMHTEGAIGYAYWVCTTLQDKSNRDTELYRYNIVQMNAIPAAQVVLSKYIERIQNYAPAFTMLGYLNEHLQLKKEAADAYRRAMLLLQTTEDQDTYNVAVRNYGRLLCSIGEYDKAIQAFKSTPLEELEDIIGFALALFMKGLYKESSKAYERALSIVESEQDKAHILTALAITEYKQGKMDVAKTLLFKCSILKEPTIESLQALCALGLTMQDATLSKAALNELLKHVKQKDSDYQKCLLTSAIYALQGRSLAVRRQASKAVHSNPADPALWSLLSRVVAQYTHQSAKGGAIAGNVAHILDSNHGKKALLYTAVNQLAMGSSSAETEKNLALKTIQKAALLSPGDPAVWAGLMAACHADDKLALVNNTQPKRMDLYLALLSAVSASLKDKEFLKDYNQSLEKWSLSQAVTGLIDTGRISEAEALCTKNLKSNPDQPAVILLLRQVQCKPLLESQKPLPDAVLEELQKTVMSNSTSVPAWQWLAHVYQSQGMMGAAEMCYRKSLQVASQQGSWSGKLSSLLKLALLALKVCMAKNFNDHWSSLVQEATTEALKLCFCPLAVFLQALLQFNRKMGARETRRLLERVVYQPGYPKSIVSTARWYLLRHLHAKNDYELIDVLVNNAKTHGDTRALELNQKLSSQ