lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biosynthesis of aromatic piperamides natural products such as piperine (1-piperoyl-piperidine), the pungent principle contributing, together with several terpenoids, to the aromatic properties of black pepper fruits, and displaying numerous pharmacological activities such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, antiobesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects. Mediates mainly the conversion of piperidine and piperoyl-CoA to piperine. Can also use pyrrolidine and isobutylamine as acceptors and 3,4-methylenedioxycinnamoyl-CoA as an alternative CoA-donor with a lower efficiency.
Subcellular Localization:
Cytoplasm. Note=Localized at residual cytoplasmic structures in special cells of the fruit perisperm.
Sequence:
MAPSSQLEFNVVRKQPELLPPAEPTPFEWKELSDIDDQDGLRLHISGFFIYPPSTMSNVGRDNVARDIRLGLSKAMVFYYPLAGRIREGPNRKLSVECTGEGIMYCEADADVRLEQFGDIGALSMPFPFMDKVMFETVDDGILGTPLMYFQSTRFICGGIVIAGCYNHAIADGLGFYMFMAAAAQLARGAASPTPLPVWQRERLLSRVPPRVTFIHHEYIHDTPKTETANPLDNEPWPLHSIFFTRVDVAALRAQLPGHLRKSATSFEIISACLWRCRTAALRFAPDELSRLIIAVNARTKFGPPLPQGYYGNSIMLPMVVSEAGKLVLSGLGYAVELVIEAKGKVTEEYVKSVADYLVLNGRPHYVVTNTYLVSDLRQLVEMSKFDWGWGKPAYVGPADVGENAISFLATLKNGEEEGVVVPIRLPESAVGRFKSEVSKMVSFGCLEDVKPNRDGYLSRM
The following text describes a protein:
Function:
Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation.
Sequence:
MSNISSVAPPPPPPPMIVTPSTPATTKERPVGDNITTDECTWACEYPEVQKGCYLSRVCQYTPPKHCQYYSVNSIVQVGPTCGLVALSMLLGGSPTADDLLKDAIDQEYTLNGELFSAQYLFELTRKHMPGPAACQLHVGPLDCKKVKELLKAGGCLLVPYDADVNHAPCVKNGHRAHWALIVGYLVDTQDRFYVLARHGKSRNLAVWPLDTLSQSNENLKEFAQPKGYPDDEFLLPPGGIGGSLGLNERCILVNGLPKQVIHVRWS
The following text describes a protein:
Function:
Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MKMLRRTKVNFSKLLYKITKLAIVLTILYIYFTPKIVSRNNASLQHIFPHKYGDYEINLVIAHPDDEVMFFSPIISQLNSYFPRTVPFNIICLSKGNAEGLGETRVRELNESAALLLHNERAVSVQVMDFQDGMDEIWDIDSITSSLSQKIDIKNHNLNQIIVTFDSYGVSNHINHKSCYAAVKKLVDDYAQPKTKRNEQPPHVTALYLRSYKNNIVLKYNSFIWEILKILYDLISPFRRIIQALPPNTAAEKDKLSLMNTHAQYVLAFATMLNAHESQVVWFRYGWWIFSRFVFVNEFDVYTY
The following text describes a protein:
Function:
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Binds bacterial lipopolysaccharide. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MENVSLALGRALWVFLLAMIGSTTSQPLGGESVCTARPLARYSITFIGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEIEAAGEKLQSVHAVFSAPAIPSGTGQTSTELEVHPRHSLVSFVVRIVPSPDWFVGIDSLDLCEGGRWKEQVVLDLYPHDAGTDSGFTFSSPNFATIPQDTVTEITASSPSHPANSFYYPRLKSLPPIAKVTFVRLQQSPRAFAPPSLDLASRGNEIVDSLSVPETPLDCEVSLWSSWGLCGGPCGKLGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNCV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MASAPIASASEQPLTSTNPQLGPEPYFTYPTPTPDQLEEELPPYFENENVSLGLVLDRFARKGNHDLRVLLGEVLPQLSIRERPKPIIEYAKTTRQALLKYLAVLRWKTSVDIASTSTGSSVANTAGPASFPTPHSNNDPNDNSPDAFAGKGKSKTQADESVIKGKVTDAKRIAHFMEHQNQQHEVAIEHVKHVTKVVEGLRERNPDLLTALSLLATGTYNRLPASLVDPYLPKPVLTNSAILKVLRRLNRQIRYRLRCLDYLPPELIVEDIKDGRMYARGDGWRAELTVVGFEDTSRWWLTGVEWGWKAKEKGVDDPGGRVTKKFTGEERQGILDIANGEVLPPRELPENEMEVDTVITEDPQVKKSEVVEVVKKTVDAPLVRVYNLLQHLSLSYRLEVLFTQAIALSQGKWRGQLIPEMDREDKTLRLKYWLRERPMQVQRQDSTSIKRPQAPATLPASRQTMVGGIIHITLAEKTTPRSELDNLLSDIACGGLVPSERVLRLELNVKWVVDEAGVGGGLKSGDVMDNSMLHLDPDALSVEDLLHVCTRTHASHLTRSHGTSLLTSPRFLNASSVQPSLQESTDPSARPLTLRVPLPSRYAVSHLLIGVSSFSGLLEVEDEGAKGNDARAERAAMSMKSVNEGKTKLVDDITRLTTAVSSVNKWFINVKY
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Sequence:
MDHFLKLLPKLTPQLRKGDCGKIAVIGGSLEYTGAPYYAASSVSRLGADLIHVFCAPDAAPVIKGYSPDLIVHPGMNASSILPKLNRMDAIVVGPGLGRNPTLWPLLQEIFNFVKNEKVPFVIDGDGLWFVSEHIEHFPRQMVTTVLTPNIVEFSRLCKSALGEEDVLNVKSSSQLQHLAAELSRKMDVTIYMKGEVDLVVTPNGEVSKCSTDSSLRRCGGQGDVTAGSLGLFLYWAKKNLGDDWTSAHHEAGISSSWLVRTAGRRAFEKHGRSMNTPLLLDEIPKLVRDVETREMKDTVHSDSSKH
The following text describes a protein:
Function:
Required for optimal plastid performance in terms of photosynthesis and growth. Required for the translation of plastid mRNAs. Involved in cellular heat stress response and required for heat tolerance. Required for transcriptional activation of HSFA2 and its target genes in response to heat stress. Plays a critical role in biosynthesis of thylakoid membrane proteins encoded by chloroplast genes.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASLAQQFSGLRCSPLSSSSRLSRRASKNFPQNKSASVSPTIVAAVAMSSGQTKERLELKKMFEDAYERCRTSPMEGVAFTVDDFAAAIEQYDFNSEIGTRVKGTVFKTDANGALVDISAKSSAYLSVEQACIHRIKHVEEAGIVPGMVEEFVIIGENESDDSLLLSLRNIQYELAWERCRQLQAEDVIVKAKVIGANKGGLVALVEGLRGFVPFSQISSKAAAEELLEKEIPLKFVEVDEEQTKLVLSNRKAVADSQAQLGIGSVVLGVVQSLKPYGAFIDIGGINGLLHVSQISHDRVSDIATVLQPGDTLKVMILSHDRDRGRVSLSTKKLEPTPGDMIRNPKLVFEKAEEMAQTFRQRIAQAEAMARADMLRFQPESGLTLSSDGILGPLGSELPDDGVDLTVDDIPSAVDI
The following text describes a protein:
Function:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Mitochondrion.
Sequence:
MYPRSNASSQSSDRTQVRSALGSLKRSWSGNQQDLGSSTQSTARKSTTGHQSSQEFFFDWSDSPSPPRRGAQANSHGVDSDKENGASEPSEKRTKSAAGPIQASSSKTSVQPQNGFVSASSIHRGSRHGSDTHTYAGDSHRPYAESYSGRSSHPSRSVDLITQFSYDRQQARSGLPMSASGTDRGSAPNSATGSSNAYARTSSAHSMSWMKTASQLKNERRNDPAAYQASSLIPSSGQADSLNINKSVNKIFLSQEQRKVLHMVVEEGKNVFFTGSAGTGKSVLLREIIKELRRKHAKRPDSVAVTASTGIAACNIGGVTIHSFAGIGLGKEAVTPLLNKVRKQRKALGRWQRTQVLIIDEVSMVDPALLDKLEEIARLIRKKPDKPFGGIQLVITGDFFQLPPVNPGGSVTFAFDAQCWDRVVQHKVNLTQVFRQKDQSFVTMLNEMRFGKLSQKTIDAFRKLERVPKYDNDIMPTELFPMRNEVDRANASRLMALQAEGQTYRAQDGGTLTGEARDRILSHSIAVPVLSLKKGAQVMLIKNLDETLVNGSVGKVIDFMDDADYDKQTGALEAGEQQREDRDKAPRISTRKWPLVRFHLPNGQTRDYLARPESWKTELPNGEVQASRTQVPLILAWAMSIHKSQGQTLPCCKIDLNRVFEKGQAYVALSRATSLEGLQVLGFRPDKVMAHPRVIQWSQSLIALSD
The following text describes a protein:
Function:
Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.
Subcellular Localization:
[Isoform 1]: Membrane; Single-pass type I membrane protein; [Isoform 3]: Secreted.
Sequence:
MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVASTSPGIDIADEIPLMEEDP
The following text describes a protein:
Function:
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Miscellaneous:
MISCELLANEOUS: Present with 36500 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSANDKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDLNSVGSEVEEVGVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQEHKQ
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
LADIIWRAGSGQGVLCLPSKSGVYLPESPQFNQDGVTEKLQLVPFGKWDELVTVLRRYIYIFQEEPGPAVLLLLYSAVLSRGLDRGLTNRSHLVSFKGSISNSVLCLLMTGRASPYLHNGVQYRGDEDNAAVAETGVLIRSPLGLLLWMGNEEKTQAANLGSRLKTPIFPVWLVICCDQTGLLFCLDRALMRDYRNEYNFQLHYFTSSHYQTSETILNISTRGFEETDPELPLSTLDKIIRTK
The following text describes a protein:
Function:
Aspartic protease-like protein; part of the gene cluster that mediates the biosynthesis of pyranonigrins, a family of antioxidative compounds. The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase that condenses 6 malonyl-CoA units to an acetyl starter unit, to form a 1,3,5-trioxotetradecane-6,8-dienyl-ACP. The enoyl reductase (ER) domain of pynA is likely to be functional during the first two rounds of polyketide chain extension, to generate the saturated C-C bonds of the alkyl side chain (Probable). PynA subsequently forms the amide bond between the acyl chain and L-serine. Although pynA has a terminal reductase domain, it appears to require the thioesterase pynI for the release of the straight-chain intermediate from pynA via the formation of a tetramic acid pyranonigrin J. The methyltransferase pynC then coverts pyranonigrin J to pyranonigrin I via N-methylation. The FAD-dependent monooxygenase pynG catalyzes an epoxidation-mediated cyclization to form the dihydro-gamma-pyrone moiety, followed by pynD-catalyzed oxidation of the alcohol to the ketone and enolization to yield the characteristic tetramic acid-fused gamma-pyrone core of pyranonigrin H. Pyranonigrin H is substrate of pynH for dehydration-mediated exo-methylene formation from the serine side chain to produce pyranonigrin E, before the oxidase pynE reduces the exo-methylene of pyranonigrin E into a pendant methyl to form pyranonigrin G. The FAD-linked oxidoreductase pynB performs the reverse reaction and converts pyranonigrin G back to pyranonigrin E.
Sequence:
MFPCSRIWSLLVAAATASAVPTSLATTHLQSVDLLLTRSSYGFLTDIALGTPGQSLPYLVDWTWTGHYVVTTLCYNDPTATYDCLNVDQKIFNQTLSSTFINQTDQYGYLYWDPNHFYFTEPAAADVATDMLRIGPTAVNTTIQAANFVFNETISAFPFSGVYGLSPVFQGDNRSVQASFYQGWRSGAWHSPIVSFIYCHDNATKAVCSGYDGLQTLGGYNTSHVQGDITWYDIIVTEAINTLDFVYAPAVINYWALNLTRFSIGDEEQELNKTTTLDGKQAAVAAFDHASYGRGAPVSVYGYQRLVELVGAKAVTLSDPPNNGEQGFYQFDCRNSSLLPPLRYEFAGSERAWEIVPENYVEVLANGTNKCTFNVRTLGDGAMVMGNFGETFAIDKYVMFDFEKLQVGIADFAW
The following text describes a protein:
Function:
Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
Sequence:
MMSITSTAGTLLCPPPVSRGGWRGGRYAVRAQAPGDGGAADSSEQKSVEIMRKFSEQYARRSSTFFCSDKSVTAIVIKKKKPLFCTGLLTTRINSELLSAPAGIMTTRPPSRPKTSGTARASPCEKGGVVNYLVLAARQ
The following text describes a protein:
Function:
Required for detoxification of heavy metals such as cadmium and arsenate.
Sequence:
MNIVKRAVPELLRGMTNATPNIGLIKNKVVSFEAVGQLKKSFYKRQLPKQCLAFDSSLGKDVFLRALQEGRMENYFSLAQQMVTQNEPAFCGLGTLCMILNSLKVDPGRLWKGSWRWYDQYMLDCCRSLSDIEKDGVTLEEFSCLANCNGLRTITKCVKDVSFDEFRKDVISCSTIENKIMAISFCRKVLGQTGDGHFSPVGGFSESDNKILILDVARFKYPCYWVDLKLMYESMFPIDKASGQPRGYVLLEPMHIPLGVLTVGLNKYSWRNVSKHILQQAATVKNADNLAEILLSINQSSIPLIQERSNSSKSGDFEHFKECIRSTKTYHLFLKHTNTNVEYITMAFWAIFSLPMIQKALPKGVLEEIQSLLKEVEISEINTQLTALKKQLDSLTHCCKTDTGCCSSSCCKNT
The following text describes a protein:
Function:
The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of the RAD6/UBC2-BRE1 ubiquitin ligase complex, which ubiquitinates histone H2B to form H2BK123ub1. Also required for the methylation of histone H3 by the COMPASS complex to form H3K4me, by SET2 to form H3K36me, and by DOT1 to form H3K79me. RNA polymerase II associated protein important for transcription of a subset of genes. Required for both positive and negative regulation. Negatively regulates MAK16 expression. Also required for efficient CLN2 transcription in late G1 and may be involved in transcription of galactose-inducible genes.
Miscellaneous:
MISCELLANEOUS: Present with 1040 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSKKQEYIAPIKYQNSLPVPQLPPKLLVYPESPETNADSSQLINSLYIKTNVTNLIQQDEDLGMPVDLMKFPGLLNKLDSKLLYGFDNVKLDKDDRILLRDPRIDRLTKTDISKVTFLRRTEYVSNTIAAHDNTSLKRKRRLDDGDSDDENLDVNHIISRVEGTFNKTDKWQHPVKKGVKMVKKWDLLPDTASMDQVYFILKFMGSASLDTKEKKSLNTGIFRPVELEEDEWISMYATDHKDSAILENELEKGMDEMDDDSHEGKIYKFKRIRDYDMKQVAEKPMTELAIRLNDKDGIAYYKPLRSKIELRRRRVNDIIKPLVKEHDIDQLNVTLRNPSTKEANIRDKLRMKFDPINFATVDEEDDEDEEQPEDVKKESEGDSKTEGSEQEGENEKDEEIKQEKENEQDEENKQDENRAADTPETSDAVHTEQKPEEEKETLQEE
The following text describes a protein:
Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MQIRKSNKVVVNRIEKVNSELLTLTYGAIVSQIIKDSDTVIEANEQLEKMGFNIGQRIIDEYLSKAEIKQCRDKIDVAENIGKVSMQMFLGVTAEVEVLPETDKIFTFNLHFTENPLNDFVELPEHLQGLNYSNMIAGAIRGALSTIHWIATCRFLKDQLKNDDKTILQVEMIREKFKDDE
The following text describes a protein:
Function:
Nuclear import adapter that specifically recruits the two functionally and topologically linked ribosomal proteins RPL5 and RPL11 (encoded by RPL11A and RPL11B). Guarantees that this cargo pair remains bound together from the time of synthesis in the cytoplasm until delivery to the nascent 5S rRNA in the nucleus.
Miscellaneous:
MISCELLANEOUS: Present with 2600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=The SYO1/RPL11/RPL5 complex is transported into the nucleus by KAP104.
Sequence:
MGRSKKRSRASSSRLNPLRKAGSNDNNKDTNVVNKKLQPLLQNLSSVVPNDRSIALSSISVLCEDAHMRQLLLKEKLVPIILNKLLNDSNSDIVVESFGLLRNLSLEEGYDVSIYLWRSDIWTSITSNFGRIVESLSALQAAEQQPQLKPAGKSKIESKRLLFDFADNLLSLVVALSNGSDDILNEILTESKINEIFQVISQLLKYGVEKLPINLFNTTLDLIYDLSSESFEFIDHVSNNELLSQFLNGLSPALHPQANELTKVLIEGIHCQFLDMKITYDQCNKMIHSVCHSINNIDPVQLVNDINNPVEIGPATSKDESSKVITKIKDYNAKRNESMIKLQSIEIAIDLITAIIEIVASKYESPESQEVAIPEELINTLTNFLPHVFMILKDTFTSRILIGWNNLIWLFVSLSLTELSGELLTTLWSYVTQLDSQDDLSIKIGRMGCIWALLKLIFPDGAFESENRALINVQMLNNSGFARGIIEEFQNNNDLELQQKCINVLSTYAMIQGQIDANKEIGQFFIQTLTQLNVRPEILIEMTNSLFQIYGDASYDYNEPIFVRGGFLSILKDQVVPNLRQQFKMVDKNKNPELKERCHDCFTTLDSFIHYKMNENSTNQ
The following text describes a protein:
Function:
Major facilitator superfamily transporter that confers resistance to azoles such as itraconazole.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLAMAASAEETNRQSNAGRRSVISPSEAPPEAEQSDVYQAPPPGLKEWLFILILCSTQLFVQGAFGYILIPLHIVGQTFGQGPSEATRMTWHVGGYSLTVGTFILIAGKLGDLYGSKRILVLGWAWFGVWSVIGGCSAFTHSPVFFDTARALQGIGPALLLPNALAIAGRTYPPGKKKNMIFSAFAVAAPLGCFTAGVVGSVFAQYVWWPWVMWTYSIGCFIIAAVGLWVIPSDYPRCQKAATLQFDYIGSVLGVAGLLLLNISWNQAPIDGWSTPYVYVLLIGGFLVLGLFELQERRAPGIRSWINFAMCLLWIQQCSSRQGPSQGILPALATPYLMAVITSGWLMAIACAAFLGGCILQSTAPVEQSYWMNTFWSFVIMAWGMDISFPASTTILSDAVPVKHQGASASLVNTVINYSIAIGLGIAGTVEAEVSHQGVNQLRGYRAALWSSVGLAALAFGIALVFAVCTFQEQRSSRKSSQEREQRACIEGCILGLTLTPDREWERVELGRLLSHVSQTGGLRSQSV
The following text describes a protein:
Function:
Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). May be catalyze the hydrolysis of formylmethanofuran (formyl-MFR) to yield formate and MFR.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTRIHGGRVVDPTAGRDAVGDVWIEDGRVVAPSERAPDQTIDATGCVVMAGGVEVHSHIAGGNVVMSRLLLPDLYVSESAPNGHPFAHAGGSGSWIGANYARMGYTTAVEPALPPSNALATHLELADIPLLDRGGLAVLGNDDHLLQLLRDGEGKQAVRDLVQQTLAHSRGLGVKCINAGGASAFKDGVLKLSLDDEIPCYGLSTRKIMSALLDAVEEIGVPHPLHVHCNNLGLPGADDSLVATLEAAEGRRIHFAHAQFYAYGVVDPENPMTGGFRSAAERINAAMEAHPNATYDVGQVVFGQTVTISLDILRQFGGRKGAKPKKWVISAGDAEGGGVVPFLYRPRGPVSSLQWAIGLELMLLSSNPERTILTTDHPNGGVFTEYPRIIHLLMDAEERAKEIATLPAIVGERSGLPKIEREYSFSEIAQLTRSGPAKLLGLTDRGHLREGAKADVAIYRDDKDRTAMFSRAKLVLKDGQPIVEDGEVVAWFSGKTLSLDVEADAGMEKRAESYLQDRFGAGLDTFAVPDAAFPENTGTFEDVACRA
The following text describes a protein:
Function:
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).
Subcellular Localization:
Membrane; Single-pass type I membrane protein. Apical cell membrane. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli.
Sequence:
MAILRSLLLPLGLLLCLWLLCSPASCTNSTTNCKPFLSVTTKKSSLIHISPDIYKSNTLYTVSTQVSHGIISVVLEARDQNKSVIGSWENPSDHCEGRAEYYLKGNFSTLFKAKWMSPNSTDITTVKINIYTVNSLRNAELDSITLPEVGTVTVKHVSTKQVITTPTHKPTPAPPKPTTNPQKTTTNHSIPTTSLPKPTTSLYTSHPKLTTTHKSSANRAFLCPVREAIQILFIFLIGTLLF
The following text describes a protein:
Function:
Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk-1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc-6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstream of Rho GTPases. In association with pak-2, plays a role in embryogenesis. In association with pak-1, may be involved in spermatogenesis.
Subcellular Localization:
Perikaryon. Cell projection, dendrite. Cytoplasm.
Sequence:
MSTSKSSKVRIRNFIGRIFSPSDKDKDRDDEMKPSSSAMDISQPYNTVHRVHVGYDGQKFSGLPQPWMDILLRDISLADQKKDPNAVVTALKFYAQSMKENEKTKFMTTNSVFTNSDDDDVDVQLTGQVTEHLRNLQCSNGSATSPSTSVSASSSSARPLTNGNNHLSTASSTDTSLSLSERNNVPSPAPVPYSESAPQLKTFTGETPKLHPRSPFPPQPPVLPQRSKTASAVATTTTNPTTSNGAPPPVPGSKGPPVPPKPSHLKIASSTVSSGCSSPQQYSSARSVGNSLSNGSVVSTTSSDGDVQLSNKENSNDKSVGDKNGNTTTNKTTVEPPPPEEPPVRVRASHREKLSDSEVLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLIPYIRAVREK
The following text describes a protein:
Function:
Glucosylceramidase that catalyzes the hydrolysis of glucosylceramides into free ceramides and glucose (By similarity). C.elegans contains specific sphingoid bases, which are unique or different in structure compared to the sphingoid bases found in other animals. Two examples of these distinctive compounds are: 15-methylhexadecasphinganine and 15-methylhexadecasphing-4-enine.
Sequence:
MKSRFLLKIFIFLAVFGVDSVRAADCTEKTFKTGTVCVCSLDSCDEIPPLDITMGQAALYTTSHTGARLHRDVIYATDTEPFGTLHMTIDSSKKYQTIQGFGSTFSDASGANLKSLPDKLSDLIMKQYFSDTGLNLQFGRVPIASTDFSGRVYSYNDVANDYSMQNFNLTKEDFQWKIPYIKNAQKYNPNLKLFAAPWAAPGWLKTTKEMTGPGALNGKAGDNYHQAYAKYFVRFLEEYGKSGISFWGLSTQNQPTLGSDKKNKIQSTLFTAETQRDFIKTDLGPALAASSSGKDVKLLILDDNRGNLPKWADTVLNDMDAAKYVGGIGVHAYQDGETDNHLDETHKKHPNFFILGTEASEGYGSKDTHVDYGNWDRAADTASDILDNMNNWMTGWTERNLILDALGGPSWVSDYTDAPVIAFPAMAQFYKQPMFYAIAHFSHFIKPGAVRIDHSLNVIELEVETTAFLNPDGSKVIVMLNKGSLVSTEHTVVVQDAADSRNHYHFTLPHRAITTLYIQTSQF
The following text describes a protein:
Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
VVAHHSGSLGLEGHESCGQCTPCSEDEQQLATNAHNFFKQNQFDSALGLLKKLNKTHSNDVCLLHNRALTEFCKSGKTKSIEFRRTLSKKALQQSHKDDEDLVIKGEKANHATLHYNQALLLFNIHQYSEAEIILEKLLQNLDVSDEKFHLSVVLLLVECYLINCNTVKAVTLMYLADEQFLIAGSNNNKTKFSNVTLSVKQTLGELSPNQLESLRNYIPQLKACCYLKQRSIKACKREIKVLTTTTSSNQQQTPNVPNITTVFLKSNFEYVRCNYHKAYKLLGSSPNMGERQQNISAMLDNNLAVIYSSMGKYHLGNFYMEKSLKENESWLNTSLKQHNNNNGGGNKANSFPISILHMNKRYELLYNRGIQLLHGGDPTSAFDCFITTASVYHTNPRLWLRLAECCIHKYTNQHESEDSPKRKTPTRCFNKVGSSVHRKVVVCSNPSHAITAGRTSNTTSATPTMEFAFICLSNALIIMEREMKHGGCLQVSVLRVVGSNPSDDSLNYHNKTHNEVKILEEKLSDVTIACLPSPPVVGTRICYLYASILCNSAFVALHLGNASVALQHAACVLNLPKIYGSHRYLANMYAGEALVVLDRISEAIQHLQVDKITNVSCAVAESGKRSPLSAICLIDNPKHPYPPNTATAHAHMMLNLAACHCLRSENEKSIKLLQQAANLIPGKSPNQGLMLAVYLNLSSGNINKAVQILQHNDPLLKFDQPLSDRPGSMASHGDNHVTGVTHVASVTHK
The following text describes a protein:
Function:
The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.
Sequence:
MADLSNIRETGYNFTTILKRLEAATSRLEDLVEIGRDSSLSQQEEPSETDTTPKQASVAAPVPEKAQTEPKADLPQLPKSVSDYDAYCKTHLTPYLQLSKKIGGLIEKQSEHVDSAFQKLRDILQLSSLCKKPVVTSPEYTEMLKPVQQELLGVTKIRDENRNSPQFNQLSMVMDGISILGWVTVEPAPLGFMGEMKDSAQYYANRVLTEVKNKDQTQVEWVRSYLKLLSELQVYVKEHFKTGLQWSTDASAADLATKLKDLKLEDSTAPSSAASSASVPPPPPPPAPTGNYWEKDDDTTPKPASSKPNLGAVFAEINQGEGITAGLRKVDKSQMTHKNPELRKQPPPVAPKPASPGSHAVKKSPAPAPSKPPRLELENTKWFVENQTDNHNIILENVELNHTVQIFNCNNCTIIIKGKLNAVSMSRCKRTSVVVDTLVASLDIANCANFGCQIMEKVPMVVIDKCDGGSIFVSKQSLDTEFVTSCTTSLNINIPTDDGDYKECAMPEMLKHTVNEKGEFVTEVIRHE
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Forms part of the polypeptide exit tunnel.
Sequence:
MATIDVFDISKNKVGVMDLNDNVFNGEVKEYLIHEAIKVQLANRRAGTVSVKNRAIVSGGGKKPYRQKGTGQARQGCIRAPHFVGGGVAFGPRPKVYNLSMNKKARKAAVRSALSMLYKENKLSVLDSFTLPSISTKGFVTVLKAFDLAKTLVVVDEPNLNLELSARNVKDVKVLKAEHLNVFDIVKYNNIIVTQSAVRTIEGVLQS
The following text describes a protein:
Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway.
Miscellaneous:
MISCELLANEOUS: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted.
Sequence:
MEENEYSGYWEPPRKRCCCARRGTQLMLVGLLSTAMWAGLLALLLLWHWETEKNLKQLGDTAIQNVSHVTKDLQKFQSNQLAQKSQVVQMSQNLQELQAEQKQMKAQDSRLSQNLTGLQEDLRNAQSQNSKLSQNLNRLQDDLVNIKSLGLNEKRTASDSLEKLQEEVAKLWIEILISKGTACNICPKNWLHFQQKCYYFGKGSKQWIQARFACSDLQGRLVSIHSQKEQDFLMQHINKKDSWIGLQDLNMEGEFVWSDGSPVGYSNWNPGEPNNGGQGEDCVMMRGSGQWNDAFCRSYLDAWVCEQLATCEISAPLASVTPTRPTPKSEP