lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B.
Sequence:
MTEETSQQAMGDIPEIAPFDPTKKKKKKKVVIQHHLVDSLHNSMGREVNESGRNAFLGSTKKKISVGTSKLLDYDSDAAGDMYDSGEADEEEDALVQQSRYPLERSERVYEYKELLQRVFSLLLENNPQRAEDKRRSVLRPPQILPEGTTRTVLVNIMDLCKTMHRQPEQLINFLLIGLGTSGTLDDENKLILRGRFAPKSLENLLQEYINENVLCNICRTPDTILSKENNIVLLQCELCGSERPVAPIGAVYGTRIARRKTGT
The following text describes a protein:
Function:
Transcriptional repressor. Plays a fundamental role in notochord formation, acting within the mesodermal region.
Subcellular Localization:
Nucleus.
Sequence:
MLHSPVFPAFGHHLAQHPAMPLAMELPRTPKASFNIDSILSRTDRPASKLSMEMPSWQPPSPPSMPYRYSYGMMPYPPVWLIKPTVGYPNMAQQQPMRMPRGECLCPDPTCKERVLPFSHCPNGAMNPLSWRTGPCKMKRIRTVFTPEQLEKLEKEFLKQQYMVGTERVDLASTLNLTETQVKVWFQNRRIKWRKQSLEQKKAKLSQFGVIPADSSDHTDDSRETEEDEDDLDVEL
The following text describes a protein:
Function:
Exporter of O-acetylserine (OAS) and cysteine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTPMLLSAFWTYTLITALTPGPNNILALSAATAHGFRQSIRVLAGMSLGFLVVMLLCAGIAFSLAVIDPAIIHLLSWVGAAYILWLAWKIATSPAADENARPKPVGFWVSFGLQFVNVKIILYGITALSTFVLPQTQALNWVIGVSILLALIGTFGNVCWALAGHLFQRAFRHYGRQLNIILALLLVYCAVRIFY
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MLDPTEKVIDSESMESKLTSVDAIEEHSSSSSNEAISNEKKSCAICGTSKTPLWRGGPAGPKSLCNACGIRNRKKRRTLISNRSEDKKKKSHNRNPKFGDSLKQRLMELGREVMMQRSTAENQRRNKLGEEEQAAVLLMALSYASSVYA
The following text describes a protein:
Function:
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
Subcellular Localization:
Mitochondrion.
Sequence:
MSSSLLLLSRTIKHNSIPIKKPLFTFTPTSTSTSRSISISTSSTCNIIRYYHSQDHININTIDNNNKIDDQILTTAIKYIPEYGFQSQCITKAIKELKYPDSMNSLFTFKKSESNQSLELQLMIHWLKLQRYNLEKYIEKNPTPGSSSSSSTSYEDRLIELINVRLSYNKPILNQLKTTGISQLILPYNLTQGLNELYLLSDDLAFYSGDESNDFSWYSKRLSIASIYVSSELFMLNDNTKDFELTQRFIKQRVYDLKKLSDGYNNIEQWLGFNGISFINLIKSQLTRG
The following text describes a protein:
Function:
Involved in the regulation of peroxisome number, size and distribution.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MSETSSSRRSASKDAVKSYFAGKYNKVLDSILEAEAAISKSPTVAEDLSGSSSSGNSEMSHPSLTASSATSQGISKKELLQQIAGSLFSTSIERLKTAHSSEVSSTPEYSVNDSYGEQECRECDGVFKCSAHFEGAPEYYDDETESGPALEPMTSNSEKDPFIDVFLDKLISRLVPEKLPEREHFSSKTTIEHDLDTGRVPVFSATTLGSNFKKLSKKMGSIFELQDSIVRLLTWRNPTGTVTSLILFTLICFNPMYLVILPIFRFVYGIVVPGYVRKHPLQRSIYPLKRNHGSSLLYDVCYEGKNEYSYGQQFFSKSFMDTLESRNQEIDEISELDKRTENTGELKQGMKVLINLRDMQNMTSGTLHVIEAINSFLRKSSSFQNEECSTKRFFTGFLLIVFLKILSPFVNWSYVCSIFAWCLLIYMHPRAHPKIISFFKTGTMGKEYKNLKKREHQALNMIFDEQPETKFIEIFEIYKKALLPNDWKFFRYSNRIFDPQDPYRRAQQFPPGVDSLADVIPPTGWSFDPNFEWKIDNDVDRWVVERGLNLPITGEFLFDPMFKRRRLIHRVIKNATPVA
The following text describes a protein:
Function:
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MWRKVGEMADTTGRIPLWLIGTVAGIAVIGLVGVFFYGSYSGLGSSL
The following text describes a protein:
Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes.
Miscellaneous:
MISCELLANEOUS: Was named 'Dasra' in reference to the Hindu mythological deity Dasra, who acts as a harbinger of the dawn.
Subcellular Localization:
Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis.
Sequence:
MASGKKKTSRKPKNRSVKNEKLASFIKDFDSQVKIITEEMKASVVNILKEVDSQYNIEIIKLPMAIREMCWLDYIAKGGSQKALEAAATVKVDMEEITSTVTKTPFKADKKVKKGKCKPDDETVELNPLKSVIRTKTKAKVAAKKPSTARRTRASVGNVANTSKRTSKRGRATPSASKQAETSLLGYTPAATPRIDTSIFKTPALRTPCMQEPVYTFSANGSPLAGMDELFINVPARDGKIIRLLASEVDGLDINRLDQQAFENIKLLSSRLERLCKKLK
The following text describes a protein:
Function:
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell. Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
KGETDNYEMYSVELDRKGPGGDMEAKLQKKKKKGGGGGKKERLENMKKEMEINDHQLSVEELEKKYQTNASKGLSTRLAAEILLRDGPNALRPPKGTPEYVKFARQLAGGLQCLMWVAAAICLIAFGIQAGEGDLTTDDNLYLALALIAVVVVTGLFGYYQEFKSTNIIASFNLVQATVIREGDKFQINADQLVVGDLVEIKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLARKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHVHTADTTEDQSGQTFDQSSETWRALCQVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFSKVCEIPFNSTNKFQLSIHELEDPRDRRHVLVMKGAPERILERCSSILIKGQELPLDEQWREAFQTAYLALGGLGERVLGFCQLYLSEKDFPRGFAFNPDEMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVEQVNRRDARACVVNGAQLKDMDPAELVEILRMHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEAAESDIMHLRPRNPRRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPHWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSIFQQGFFRNRILVIAIVFQICIGCFLCYCPGMPNIFNFMPIRYQWWLVPMPFGLLIFTYDEIRKLGVRCCPGSWWDKELYY
The following text describes a protein:
Function:
Involved in the catabolism of oxalate and in the adapatation to low pH. ACOCT serves to prime the oxalate-induced acid tolerance response (ATR) cycle by producing substrate for oxalyl-CoA decarboxylase (OXC) and formyl-coenzyme A transferase (FCOCT). Catalyzes the reversible conversion of acetyl-CoA and oxalate to oxalyl-CoA and acetate. It can also use formyl-CoA and oxalate to produce oxalyl-CoA and formate with significantly reduced specific activity.
Sequence:
MTNNESKGPFEGLLVIDMTHVLNGPFGTQLLCNMGARVIKVEPPGHGDDTRTFGPYVDGQSLYYSFINHGKESVVLDLKNDHDKSIFINMLKQADVLAENFRPGTMEKLGFSWETLQEINPRLIYASSSGFGHTGPLKDAPAYDTIIQAMSGIMMETGYPDAPPVRVGTSLADLCGGVYLFSGIVSALYGREKSQRGAHVDIAMFDATLSFLEHGLMAYIATGKSPQRLGNRHPYMAPFDVFNTQDKPITICCGNDKLFSALCQALELTELVNDPRFSSNILRVQNQAILKQYIERTLKTQAAEVWLARIHEVGVPVAPLLSVAEAIKLPQTQARNMLIEAGGIMMPGNPIKISGCADPHVMPGAATLDQHGEQIRQEFSS
The following text describes a protein:
Function:
Involved in the biosynthesis of the phytotoxin coronatine (COR) which mimics the plant hormone jasmonic acid isoleucine and promotes opening of stomata for bacterial entry, bacterial growth in the apoplast, systemic susceptibility, and disease symptoms. CmaA catalyzes the adenylation of L-allo-isoleucine (via the A domain) and the attachment of L-allo-isoleucine to the 4'-phosphopantetheine arm located within the T domain of CmaA. It can also use L-isoleucine, L-leucine and L-valine as substrates.
Domain:
The didomain protein contains an adenylation domain (A domain) and a thiolation domain (T domain).
Sequence:
MTSYHSHPPKAYRRFESVCTQAPNAIAVVHEGKPVTYQQLQTQVLERSEALIRQGLADHPYMPLMANRCLEYLITMLACCKLGITYVSIEPSTPSKRLIAVLEQLGCNHLLLLGQPTDLRPDPTLTCFRLDDCGTLCSDGPALRQPIRRRLDDASVITVMFTSGTTGVPKGVRISQDGLLNLVDNVQQQVQGKPRSYVHHSSIGFDAALFEVWVPLLTGACVTLQPSEFNIDALDHCVRAASCDVLLLTTSLFHLVAQHRLSMLEAVRVLYVGGEVLKPVHARALLLANPRITLVNGYGPTENTVFSTWYSLNKPEDAERDVIPIGQFLHQVHGKIVDAKLQEVEVGTPGELLLTGANLALGYLDEALTPTRFLQLPEGTYYRTGDYVIQDEHGMLFYQGRIDEQVKIKGFRVEIAEVEHALTQLPGVAQAVVQAHVMNDLENSLHAFIVFRHGSPTIEESKLMSLLGDRLPHYMVPRRIHYLAELPLTANGKVDKRSLQPPEKAAVVSPQAGSAVLEIWSGILGTRNLQLEHSIYGYGASSLSVVMAHSRINEILGRTTPFDEVARLSTFQEWVQYYATHADPVTSLRSQHGNH
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MMAQPSTLESLIESFVTTEKSPAEQARAQASSAKAISKRILHGELTIQSLVLTLGAYLTTTDNIVRHRGTLLLSDILADLSGKRLEDTAIKSLTNFYSARLGDWHCLQGAVLGSLSLLRRRSNAGTVEVEDAREVAKSALTNLHVQALARKDRMLCLELFECLLEKHAGAVTPLKDDLVFGVVAAVEEEKDPRCLLLAFRITRLLAKLYPDPEGPVASCAEELFDVVSRYFPISFNPRPDSPDDITREDLANSLKATFACTPIFAPYCIPLLLEKLSSSLRRAKLDALNYLGHCGLAYGAKALKEYTVAVWDALKAELLPPSMPSEEPQDVEIVKEALSCLRSWVLASQIENDSSLLSMRDSGIMKAGDFLQLILQDGLVEDLVTCLKNDTVSRGHTQSLMKDRAIQQAEGAGHILAESAQASPSSCFVVCRQVLNRLMTATGLSIVSNATPEIVAAAASEAQAGTNPNLDNFKSVIGLGVVLQIVIAARNLAEKCFQERGQSLAMTPKEWLDPLQEQAENLLTAFHKAITDELSRDSAVLGVSGLQALASFPASLSPVSSDQLRRILLIFKDLLIGDINQELLDIVLIALENINNVEERSGAVDEGNVGVLTVVVPDLLGAVREAKSGTEVGKPLRVLAKICGSRSGARPLVIKNLTESIHLGISRANVREDVDDVSTKLVGVLRCISEDILPWCDDLSANQSVMTELTTEIWAVVSTQAFRCNQSVLEWSSKVMRVAVVKFDASAQSRILQHGAQLLFDTTRHHEEEMDWTIALVASVIVSVRATAVVPNKQSLLTMMMRAAQSDKAFLITETAAQAVASMLNKWAVSTDEDGGFTLEKAVHMVLDEDFLSQIVPKSRLESSAEIDKGKDFPCKSVRQKVSGVRAAAWIGKGLAMRGHSGVSVVASVLLKLLLSGTSEEGEESSLATAAAEGLGIILKESDVCLNKTHHAVVRPLFKQRFFSSMLLPLLEAVRSSSETQTKLWLYRGIGHLISGTPHVALLADGAKVFPVILGTLSFLCSDRSDSDILLSTLLALSSFLVDENQGRPVVGEHVSSIVKRLLILIQYQHSVIVRETALQCLGAVVGLPYNRVYPLRREVLKALSAALDDKKRVVRKEAVRCRQAWTMISTKKT
The following text describes a protein:
Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTAWNTDRHLTQPYEWAEPVPLKTSLQRAREVFATLLNLLVFAFESVPLWWETLVAQFVTPSSKNISGQTALVTGGANGLGQSIAIALAKEGCNVAVVDVDETNARKTVASLRRYNVSAEAYKVDVSDYEAVRQLGRDVERDLGPVDILVNNAGILPTSFSQDALPSHIERSMGVNVLSSVWTTQTFIDSMIRRRKGHIVAISSIAGYIAPGWAKTYATTKFALRGFMDALEDDLYLRGQANHVHTTTVFPFAFNTRKQAISLLKASSGLTRLPIYEPAMLGETVVRAIKTNQRKVVVPEVLKPYQLSIYENLPIKIRQLLTRTMAQGEVKLVD
The following text describes a protein:
Function:
Catalyzes the hydrolysis of various purine and pyrimidine 5'-nucleotides, showing preference for 5'-nucleoside monophosphates and exhibiting the highest catalytic activity toward 5'-XMP. Also shows a relatively high phosphohydrolase activity toward the nucleotide precursors ribose-5-phosphate (R5P) and 5-phosphoribosyl-1-pyrophosphate (PRPP), and toward the non-natural substrate p-nitrophenyl phosphate (pNPP).
Subcellular Localization:
Cytoplasm.
Sequence:
MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI
The following text describes a protein:
Function:
Putative transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLVGKISGYEDNTRSLERETSEITSLLSQFPGNTNVLVVDTNFTTLLNMKQIMKQYAYQVSIETDAEKALAFLTSCKHEINIVIWDFHMPGIDGLQALKSITSKLDLPVVIMSDDNQTESVMKATFYGACDYVVKPVKEEVMANIWQHIVRKRLIFKPDVAPPKPRMTWSEVFQPVQSHLVPTDGLDRDHFDSITINGGNGIQNMEKKQGKKPRKPRMTWTEELHQKFLEAIEIIGGIEKANPKVLVECLQEMRIEGITRSNVASHLQKHRINLEENQIPQQTQGNGWATAYGTLAPSLQGSDNVNTTIPSYLMNGPATLNQIQQNQYQNGFLTMNNNQIITNPPPPLPYLDHHHQQQHQSSPQFNYLMNNEELLQASGLSATDLELTYPSLPYDPQEYLINGYNYN
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Subcellular Localization:
Nucleus.
Sequence:
MVVVEVLQGDSAAAVADDLFGSGADLQAFFDHAALDVKASGGGEEGEEELEWLSNKEAFPAVETMASSAPRQRTKGVPPPRWEVGWSPRQAPAVARPPAAGWRCRHCGTDKTPQRREGPEGRSTLCNACGVRYRSGRLVPEYRPASSPTFSPELHSNRHSRVVEMRRRREAAAGASLAAAGKGEEKGNEKLECLSNKGEFLAVQMMAAARPRTEGTRRPRKAVDWPAIAWRPPPPPRAPAVAARRPSQGGGVGVAVDQGRAPGGGDDGVGGCAAAYQGRTAVPADGGLNPAAPLAPAAAPGQQFGTEKTLQRLGGAEGRSTLCNACVVQYRSGCMVPVLPPACSPAFSPELRFDWHNRVEMHRRRERSAKLPPATARAGEKGKEELEWPSNKGVFPAAQAMSPAAAGARPQTKGVRRQRQRQQLRRRRVVELSPPRTPPPLRRRSRCGGEAAAVEQGRVRDGGAAADEVLAAAPAGGGKDPAAPAAAPRTPAVSRRRCRHCGTEKTPQWREGPEGRQTLCNACGVQYKSGRLVPEYRPASSPTFSPGLHSNCHRQVVQLRRRREESAEVSPAAAAVGDK
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSKNIYNNNAQNKRTNRSLYDDEDGPAHVLQTNDEDGTNKYKWENRFEKTWLTIDEDEHGLRPSNQEERNTRNRRLKNKDRDGILSQDQRVRRGMQRHLCLILDLSKTLSNQDLKPSRYQVLLQNVELFIKEFFDQNPISQLSIIITKNSKAEKISELSGNRLRHIQAMKDAIAMEGEPSIQNSLEVALSSLCYVPKYGSREVLFIFSSLTTCDPSSLQKTIQSLKNESIRVSFIHMAAELYICKAIAEQTNGTSKVILNEEHFNESLMLKCQPPPTIGKTEAALVEMGFPQQITSTVPSPCICHEKMKYSGYICPRCGVKSCELPTDCQICNLSLVSSPHLARSYHHLFQIPLFNEVNWKELNKNVTCIGCLSSSEKSILSLFFSCPRCQEIFCLDCDLFIHESLHNCPGCENKLQNTNTNTNGKTNGNEITNGNGNGNGNENENGNGNGNGNGNGNGLH
The following text describes a protein:
Function:
Involved in seed germination.
Sequence:
MAYLSFKSNMERTPRESNTPCPPPQPSPSLFSSLPDDIVLNILARISTSYYQTLSLVSKTFRLLILSKELDMERSYLGTRKPCVYVCLQSPTHPFDRRWFGLWIKPYDHQPLTHWTIDIKCTGHWLLPMPSPYSRCLQIVHETVGSETYEIGGQNMTPSTDVWVYDKLIGKQRKAPSMMVARKNAFTCVLDGKLYVMGGCEADESTHWAEVFDPKTQTWEALPDPGVELRYSSVKNIQTKQGKVYVRSNKKNFVYLIKECMWEVAEENLGESTCEIENVCYCYSNKRYWWYDAKCEEWRLVKGVSGLYEYYKTDSEIGNYGGKLVVFWDRAVSRLTATKEIWCAMISLEKGHDGEIWGHIEWLDAVLIAPRSYALSHCMDFLQ
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MADVMAPPTPPHEVAAKDDITLDIDWSQVNLDEIQLPPGDDLGIHSDEEEDDEPDLETESGFGNIIVVDNLPEVPPEKYEKLVGVIRKIFARTGTIRENGLWMPVDEETKQSKGYAFIEYNTPQEADVTKEQTDEYKLDKNHVFKVTKFDDFDKYSKVPDQYVAPEKKPYQTKEDLLWWLQDERARDQFVIRYAAETEVYWNDARLGKPDLVYHRPVWTESFVQWSPLGSYIATVHRPGAAIWGGESWGRLARFAHPQVRLLDFSPGEKYLVTYSSQEPANPRDTQKVTLSIWDIRSGKKLREIAGNANDFAVGGAAGVAGIQWPIFHWAGGKEDKYFARLGKNAISVYDTKDMGLLDKKSVKAEGVASFSWSPLEPLLALYTPETQSGNNPARVSLVAIPSRVELRQKNLFSVSECKMYWHPAGEYLAVKVDRYTKTKKSTYPGFELFRIKERDIPIEVLEIENKNEKVVAFAWEPKGHRFALIHGEGPRPDVSFYSMKSKTGQDKLTLLTTLKAKQANALYWSPQGKFIVLAGLKAINGQLEFFNVDELETMATGEHYMATDVDWDPTGRFVATSVTAVQPMENGFQVWSFQGKLLYRVTRDRFFQFLWRPRPASLLDASTEAEILKNLKDLSKKYLEEDEAAEQGQNKELLEKRRQLMDEFKARQEHWHKFYEEERELRRSLRDGDESDDEEDYEYEEVEVEEVIAVTEEIVG
The following text describes a protein:
Function:
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity.
Sequence:
IHRSGRYGTQQQRAGSKTAGPPCQWSRMASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ
The following text describes a protein:
Function:
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Sequence:
MNEIVITDTDFCRFRDYFYQKTGIFFENSKRYFVDKRLLQRIELTEHQSFRGYFTYLRFQASGEELQAVINALTVNETYFFREISQLESLVEEVLDDIVRHRPGELIRIWSMPCSSGEEPYSIVLFLLEHWPKLEQVDIEIIASDIDTGILQKAAQGIFSARSVKNLPNSSLNKYFSLRADGSYQLIDDIRQSVRFTQTNLNNRAEVQKLGAMDVIFCRNLLIYFDDISRRNAVESFYEQLNPGGVLFLGHSESMSRISSIFHVKRFRKSTGYYKPHKGKSDEKSNGR
The following text describes a protein:
Function:
Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. The substrate preference order is propionaldehyde > DL-lactaldehyde, DL-glyceraldehyde > crotonaldehyde > glycolaldehyde > acetaldehyde, acrolein > formaldehyde. No activity was observed towards methylglyoxal or glyceraldehyde-3-phosphate. Has a preference for NAD over NADP.
Sequence:
MFIDGKWINREDMDVINPYSLEVIKKIPALSREEAKEAIDTAEKYKEVMKNLPITKRYNILMNIAKQIKEKKEELAKILAIDAGKPIKQARVEVERSIGTFKLAAFYVKEHRDEVIPSDDRLIFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVCIELAKIIENALKKYNVPLGVYNLLTGAGEVVGDEIVVNEKVNMISFTGSSKVGELITKKAGFKKIALELGGVNPNIVLKDADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADKFIEMFVNKAKVLNVGNPLDEKTDVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGKRDKALFYPTILEVDRDNILCKTETFAPVIPIIRTNEEEMIDIANSTEYGLHSAIFTNDINKSLKFAENLEFGGVVINDSSLFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIIISK
The following text describes a protein:
Function:
Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2. Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis.
Subcellular Localization:
Endoplasmic reticulum membrane. Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MAAAAAELVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDEDDASKCTQIKTALKYTLGFVVICALLLLVGAFVPLHLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLPARDRRALKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYIFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MVVPRVGAGRGAVPRKPTHFSTKPAEATDTTALRLNPCRRGLFLETLNITSKEGSSWDVALNQAAVEALYSAAYIEDYLDCVENLPDDVQRNLSQLRELDVKYQEVLAELEQQQGLLRRRDLDGSRKKVMLQIQHSLIKSQELGDDKLQLLQQIQDMIENKARQLDQDYRNLDHEPETREAKRSRRQRGHDDDQPPSAHPACNRRQPKKKRRRGGSNAGGTTHQQHHHQQAHQQGHQQGNQQRGIPSPAEPPIDPDEPTYCLCEQVSFGEMICCDNEECAIEWFHFSCVALTTKPKGRWYCPRCRGDRSNQMKPKGS
The following text describes a protein:
Function:
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom20 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Docks tom20 and tom70 for interaction with the general tom40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type II membrane protein.
Sequence:
MVKLEEVVDETEVQNEQQTVIEKDQYIYAQEDVEESDSDESDFEGLEEETIIDRIAALKEIVPVTWRVKIADGAKTATTGLSKLAQFGGKSMWVISTSALLLGVPFMMSLEEEAQLTEYEKQIKDQRGANEVIAPGATSGALPQ
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
Sequence:
MASESMNAKQARNHFTKGKKQQQQQVKNKSSVSDGAGEDSFIFEANEAWKDFHSSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYSAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGSEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGVASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSELHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCACLTSQIRDLNPLVKRKEFEDEQVNYMCFNSN
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MIGPADDLLDICGDFFDQIDDLLDFPTGEMEGEVIGGDCNAFWTAPPPDTLMGGPNAVFSGNNDSSRSELANELSVPYEDIAQLEWLSNFVEDSFSAGSSITIDKDSSTNDQNSYQFQTSSPVSVLESSSSSSGSGGRTMPLSPETIVPGRARSKRPRPATFNPRPVIPLISPTSSVTDPSPSFSASELASEFENHAESRPWKKVPRSEMLGQKKKKLSPAPGAKEQYAPAQPVAVRKCLHCEITKTPQWRAGPMGPKTLCNACGVRYKSGRLFPEYRPAASPTFVASLHSNSHKKVLEMRTQAGQKAEMAATGTPITDATELIPNSHLLDYI