lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Salivary chemokine-binding protein which binds to host chemokine CXCL8.
Subcellular Localization:
Secreted.
Sequence:
MELNAFTILHIAVFIAVGYYANTHTTVTGSVEGKPNNPNEDIEVSYCRMNCTVENGVSSACSGDCVCVHRDNEPNGICVEITYFGDFGDPSQDPSIDEAAPRESVSKRRSNGES
The following text describes a protein:
Function:
Binds medium- and long-chain acyl-CoA esters with high affinity. Can interact in vitro with linolenoyl-CoA. Binds phosphatidic acid (PA) and phosphatidylcholine (PC) in vitro. May play a role in the biosynthesis of phospholipids.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGLQEDFEEYAEKVKTLPESTSNEDKLILYGLYKQATVGDVNTSRPGIFAQRDRAKWDAWKAVEGKSKEEAMSDYITKVKQLQEEAAALKAVFRAYLVGEMNIFECHIGRLTRCRRGFRTQMKKQIVYSPGTREMNLLSLIKPSLAHVGYCSTYG
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MTTAVLGGGLSGLSAGYYLLRRFGKPLTIYEASPRVGGWVRSENRKDRNFIFESGPRTIRPVGEPGANTLELVEDLKLEVTPIRRSHVAARNRMLYAKGQLCMLPNSPKGLFGVLPPFTKPLYKAVLRDLFTASKKAKLEDESIYSFAERRFGKEIADYAISPMICGICAGDAREISVRFLMEGLFEKEQKYGGVLKGTLISRFEKNKTKDTKDGLFAERQPKLYAQAVKEKWAMYGLKGGLENLPKTMRKYLGERDVNVQLSNECRNLTFSSSGVRMNIKDAEVPVEHVVSSLPAYKLAPLVKQQHPSLSAQLLSIPYVDVLVVNMQFPGKLLKQDGFGLLVPPVEKLPLLGVIFDSCCFDMGENTVLTVMMGGHWFDQWFGDRPSPKQILDLATSHVQKMLQIREEPKFSRVHTLHKCIPQYTVGHKRRVEAIRNYIKTYKLPLSVCGAAYDGVGINDVILSARRQVEAIPLS
The following text describes a protein:
Function:
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
Subcellular Localization:
Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.
Sequence:
MKFLVLAALLTAGTAASGVSPTALWQFRGMIQCTIPGSSPYLEFNGYGCYCGLGGSGTPVDELDRCCQTHDQCYTQAKKLSSCSFLVDNPYTNSYSYSCSGTTVTCSSKNKECEAFICDCDRKAAICFSKRPYNKEYKPISKYC
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNYILIGVILGIVQGISEWIPISSKTQVLIVSSTLLGLSFNVAYSFGLFMEIGTIAAAIFYFRSEISGLLKALVRMSSRREDYLLLKFLVIVTIITGLVGVPLYLFVISLPILGLPMTVLGVVLLIDGIVIYLSRKNYFPRKGLHDLKLRDIIIVGIAQGLAALPGVSRSGMTTSALILLGVKPEEAFKLSFISLIPAALGAISVTVLFSKHEVSQAVHSVSLSGLLISIVVATFVSIFFINALLRFARTNKVVLLVIILGIMAIISGILSDIAKGFY
The following text describes a protein:
Function:
May play an essential role in M.tuberculosis replication and survival inside the host cell.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MVWMRSAIVAVALGVTVAAVAAACWLPQLHRHVAHPNHPLTTSVGSEFVINTDHGHLVDNSMPPCPERLATAVLPRSATPVLLPDVVAAAPGMTAALTDPVAPAARGPPAAQGSVRTGQDLLTRFCLARR
The following text describes a protein:
Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
The following text describes a protein:
Function:
Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein OPG116. Serves as a bridge which links the DNA polymerase OPG071 and the uracil DNA glycosylase.
Sequence:
MTSSADLTNLKELLSLYKSLRFSDSAAIEKYNSLVEWGTSTYWKIGVQKVANVETSISDYYDEVKNKPFNIDPGYYIFLPVYFGSVFIYSKGKNMVELGSGNSFQIPDDMRSACNKVLDSDNGIDFLRFVLLNNRWIMEDAISKYQSPVNIFKLASEYGLNIPKYLEIEIEEDTLFDDELYSIIERSFDDKFPKISISYIKLGELRRQVVDFFKFSFMYIESIKVDRIGDNIFIPSVITKSGKKILVKDVDHLIRSKVREHTFVKVKKKNTFSILYDYDGNGTETRGEVIKRIIDTIGRDYYVNGKYFSKVGSAGLKQLTNKLDINECATVDELVDEINKSGTVKRKIKNQSAFDLSRECLGYPEADFITLVNNMRFKIENCKVVNFNIENTNCLNNPSIETIYRNFNQFVSIFNVVTDVKKRLFE
The following text describes a protein:
Function:
Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.
Sequence:
MILLQLLLFPSLLSHSLAAVLPRHSQRILNPTADDLTKIFTFSNDFPAPNSGNLQVHDPNIIEEQDTLYLFRGGLHIPYWKASSISGPWTKVGTVLSKASVINKKNNNHPWAPTVTKYKGRFYCFYAISQTGSQDSAIGYASTSDLEKEWTDHGALINTGSGERSQIAPYKNTNAIDPAFQVDQKTGQPYLIYGSYWDDIYSLPLQVNQDGTLAIKNENKPDATHLSYQPGNWRPQEGAYMSYHEPYYYLWFSQGICCQMVQKGFPLKGEEYRIRVGRSKSITGPFVDRSGKKLLEGHGETVYGSNNGNVYAPGGEGVLPGNGKRGDILYYHFCESFPIPMGLSG
The following text describes a protein:
Function:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway.
Sequence:
MAGAGPTMLLREENGCCSRRQSSSSAGDSDGEREDSAAERARQQLEALLNKTMRIRMTDGRTLVGCFLCTDRDCNVILGSAQEFLKPSGQCPGNAHPPDSFSAGEPRVLGLAMVPGHHIVSIEVQRESLTGPPYL
The following text describes a protein:
Function:
Binds to DNA.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Nucleus.
Sequence:
MRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSATPSALVSPSSDCGHKSQVASSAAVAARTADLSE
The following text describes a protein:
Function:
Positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2), urea (DUR1 and DUR2), arginine and allantoin.
Miscellaneous:
MISCELLANEOUS: Present with 704 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDPHQSPADNAASPTKSVKATTKNSSTNNNVNSNNSNNNSNHDILNFNDNYTTILQHLANDHPNILREKGGSQQQQHQQQQQQQQQQQQQQQQQSLDTLLHHYQSLLSKSDNAIAFDDNVSNSADHNGSNSNNNNNNNDISSPGNLMGSCNQCRLKKTKCNYFPDLGNCLECETSRTKCTFSIAPNYLKRTSSGANNNMPTSSNSKRMKNFEDYSNRLPSSMLYRHQQQQQQQQQQQRIQYPRSSFFVGPASVFDLNLTKHVRLDNVDQIQLSKTLSLRKVSPTAQFILQDDFDTTLHSKQEYEVDLVENLVHPHGHLLVEIFFKLIHPFLPILHERVFLEKYSRSYRELTAPLLASIYSLALQYWDFHPALLGFPKPDVTAQLNNIALETFYARVGRPKLSIIQTGLLILQCRSECHNNWVLCSSVVALAEELGLGVECNDWKLPKWEKDLRKRLAWAVWLMDKWCALNEGRQSHLILGRNWMIKLLNFDDFPLNSPTILNSLQNDQSGSSPSSSNDVKNHQIAFGNLPIFNINPTLEDFKNGTLMFQQMVSLSIILGEIMDTFYTQGSMTINKSIEQVLKLAKPLQLKLREWYHSLPKNLSMSYATPQKLNSNSTLTLAYFATEITLHRKIICALNPQTPKELVQVCRTAARTRLVAAIEFIRDLKNEHINAFWYNCSTGNLMLIGTFAALLYVTSATKEEAMIFRDYVRNYTWVLKIGSKYFDKLSNALNNMHLLFAQIPGLLTDEPVVVSPNSNINSVNPQRSGVQSQIPIQFNVGSPAMTEQGSPLNQWKNLPQEILQQLNSFPNGTTSTTTPVNPTSRQTQLESQGSPAINSANNNSNNTPLPFAPNKSSKKTSQSSPNVTPSHMSRHPPSNTSSPRVNSSTNVNSNTQMNASPLTSINETRQESGDAADEKTAGRERTANEESSTELKDDNPNSNQETSATGNQTIKMNDDKNVTINTRETPL
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MPVLKPLAGSKDAPQQHKQTSRKGKKAWRKNVDVTEVQEGLGEVRDELIAGGVIAEKDSADLFTLDTAGDAAIPKKYLKASKPLKADEIIAQRSAVPAVSMKKRPGQGTTDGIIESKRQRTGYISHKELTRLRKIADGHHEKTVEATEASFDPWDEQKDIEEATQDPRFSFLEKAKKTTIPSSWRQKPVSLAATGKDIPAVKKPEGGYSYNPVFTDYEERLTAEGEKAVAAEKKRLAAIELEQIKREAANKSAAEAEAAEARADMSEWEEDSAWEGFESGAEDVRLNAKRPERKTQVQRNKIKRRKEEERKAKMAAHNKKKEEQAAQVKKLAKALEEKEKARSLMVVEDDSSEGDDMELRRRKLGKISLPERDLELVLPDELQESLRLLKPEGNLLKDRYRNMMVRGKVESRRPISFAKKAKRKATEKWTHKDFMLH
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which positively regulates the fast polyspermy block during fertilization, preventing entry of more than one sperm into the oocyte. After fertilization, required in the zygote for the selective degradation of a subset of maternal membrane proteins including cav-1, chs-1 and rme-2, probably by mediating their K63-linked polyubiquitination.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Domain:
The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity). It is also required to prevent polyspermy.
Sequence:
MEDFNASLGPAVCRICMCGETSIPYLGQQAGEPLISPCKCSGTMGLFHRSCLEHWLTLTSTTNCEICKFAFKIKQKSRNFIDYIRQGGYKKLQSNRNPFIDFAFVLLILPFAFFGVFMSVEGALYAGRKYHYAFENRDNDENGNLEVRNQTSLECALFLFVALLLFSAFITLVVSALWHHFRQYKIWQAKNKIMFVVDQLDAEQSMHFNPQWKKQGGGWKEKIAKFWGEIRRRPTRAYIPEIARNDSIPIEPVVGISPVLVANFNRTSPDSNNTHHHDESRNEIPFGRRTPEQAICVSMSSTPQMYAEKLEKLTLSPIGLDDLFANSRATSTRRESGISPESSSRRDMRKTHSVYSVCSSFGTGVMSCSTPVADNNLRTLTPSPISLSTFKSGCPTEPVVAINLNDSGDTVTIDSQRGRFHVETLENDYNS
The following text describes a protein:
Function:
Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in oocyte development, acting cell-autonomously in the somatic gonad. Involved in negative regulation of oocyte MAPK activation and inhibits oocyte maturation and ovulation.
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Note=Perinuclear localization only observed in sperm.
Sequence:
MALHEPPSKLNRHSHSNLLKPPSLNKPILTFADNDCLKTPTMNDMLKTPTVNSPRHTPMNIDGTPKVNGFSGFTPQTDQKFFGEHEPLFNQMHTTTLMPAPSSSYKEPAYSSEQPSSSSDEAKPKELLGSNSFGVPRMTNGNSKQKPEELTLKDIEISSTGPGGVDSPGLSAAMFQFSPMVEHFLQNLTNKAGLPELVVDSKTAGLNHQEPSDLIKSVQVRRSSIEDQKFSDVLHVPTLPRKTSEPSHLGSSLQNEHPQSNSRPSTVIPRVQRTNTSASLTRSMDHSSMSPISAHDDPYSNSASYSSLSTHTSFSDSASLAHFEPKTEPMDDYSYNFSDNDFNSFEFSSTSEELKNIGCQKMKSSKMPLQDRPYKCPRDGCDRRFSRSDELTRHIRIHTGQKPFQCRICMRAFSRSDHLTTHVRTHTGEKPFSCDICGRKFARSDERKRHTKVHKTSRSGS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSATNSVPNGCSLEDCHSNVFALTDLTGIKWRRLRAPCPAGVGPLEDPILSSFAKCLAADVFCVWRRLSPSTAPKFPGDSFQGEPSTPTPKQERELWIFWYGDDPDLTDVLHPELKDIEQGSWEKELSYECRTLLFKALHNLLERYLLSADFVRLGRWFVRPYIQGTDKNDKCEYLSCAFSFFLHGESTVCTSVEIQEHQLVERLSMQHFNSVQGTAGGFHVLLSPYGLHATLTGRTYKASDPTTQRLLDEWKHFYPLSDQASADVGAAGDASSTLPVAVEVVVGGVRMCYPTEYVVVPMVHCEEGTQTTSGGGSLSAVQPAMGKASAPMSTLSSMSLTPPTSPLNQSVLPSGTRTGNPACPANPAEDELGFRDVSPERLARKVATQVWQDSCVTIGVKRPHPDATNNAGDDGIATDLGNWDFIDPTQKVDCKCSRQKVKLRSSGHGSSRPAPSSSSGLSKHTYSAWTSLGGTSSKHKQSDKSEKQEKQQQPRVRPLTPFHHRAPTPSVDSYMGVDQENFTNQRLGLGMGPLAGGGGQGVDNKRFLPTPGSVESSHSAAPSPLVAPSGTASSSLPGERTMPTLSPHPIIKKENDMGPPTVTSQRECSLPFANNTAVVTEVQRRLDKKAANEYKGLPPESEKEDGRWKCYKLPKVNTGKEFHRPALAPTVFDTAGFENEEEGTSGQLPDLTVRPALGVLERPLKKMKTNFSFRPIHPAMDTIHSDSSSRSLMARTSPGIDPYEFMEDSSPPSLMPTGFPPRGKSSKKGRLQSLSSQSDRNSTDSQSNKGAEGQNQAGTAKGEASAKSGEKEPKLSSPQPAVKVVSSTSLTTEADLAVTFSDLDQLFESSDSDNDDGGPSASGGAKSASAASTEDTAQTHLHKSSGGTGNIADLQNLQTMFPTPPSVNPSLSPCNAGNQEYTSPDSVPGITKADGHAATALADYPEVEVDESMGSPVPEQIKDWSYVYRKANTHLHCGSSMYAPLKSLPSHKLPPIRLKDNMLYKPSWQMPVKDYPTVTAGGFMDLMPLPQDMINSTCPITMTTVTASNSVPMASPAFASVKTPRSAGGPGPYDSPPSTVSSFRNVNSVDMNSVGPTMEAHSLTVNMLLSDSAINLFKDRNFDSCVICVCNVNIKGADVEVYLPEFHAQNQEAQYKCTCGFSAVMNRKYARKAGLFPEDLCEIFGFKNVKRLKDNVSEVNRTSREGDSAQSGKTDEKATLNMKLAGNNRISKALLQVVQDQCSSLYSTPHSLDRIVANRRPSVVSQKIEVTICDDCDACHWALEQGRSHDGSPVKLEQADKAVCQHTWPPPKAVDQSSLSSRDVVRMLQSLQPLLQDAIQKKRTTRLWEPKPTVQGPLTWSQFHRLVGRGGDENSSEPLPVPSLLVGYEKDWLSLSPFALNHWEKLLLEPFGTSRDVVYVVICPDNDTILSNAKAFFRELSTVYESCRLGRHRPITTVLRDGIRRVGKVAAERLADKPVDEWFNKLDAVPVGKKLKLYAQVCKHDLAAHLATVTLDTSLLKALPTPGKNSVTSNSSNSTTGTSSSGNTDKPPSVPPPPSSGDGKEGESPKDPNNTGGESSEGGQNKENKDGSPDEVDEEAQPLAVVVYIVDPFSMGPENGHLTDVYALGLLKCYTEILQADLPDNVRNNISLQIIPVQQLVQPQKAEERATYLQHLKTLAFSVFTQSHRTLQFTIHAKSVTGFGPSAQNEAILKSKETDVLHLYTPPYILAPQKDKQTELVESFGELTPKSGVLFCAYCLSSDQRWILATVTDLRGELLDTVVISVEAPISPKPRKVSACRMGLQKLWEFVLSVIATTTFPWRIVIGKLGRIGHGELKDWSSLLSRQRILKSSRNLKEVCRMCSMSPQCECPTILSACMVSLEPESALRIFHESVMSGSAPGARPGGLLGSQLSTPRDASCTHLMAFPTSATTQAAAANFSITETMDLGFAGNTGDMLGDDDLLPVLQEDLGDSDLNQFLGLAASPTALTSPVHSPQSPTGGGFSGGGQSNPYSGGGDGSGKTSSSQPLPDPDEIPMLLQQPLALGYFISTAPIGDMPKSFWSACPHAEGVCPVYLKSALHVHTPAVQQNSEEILQSRHSHPLDSNLTCDVLRYVLESYNALSWLTYDPVRRDRRSCLPVHMVVLTKLYNTMATLLT
The following text describes a protein:
Function:
May be a carrier protein for lipids.
Subcellular Localization:
Secreted.
Sequence:
MENRLVLLIVINTLLLAQAAAKQDFHKKCLASSGANADTIAKVRNGKFSNDPQTQKYFGCMLRSVGVVNQAGQLQVAALRKQVPKDMKRDEAMKIYMSCKDKKGANNDETAYLLYKCFWEASPRHVKIDGQ
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Miscellaneous:
MISCELLANEOUS: Present with 1660 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum. Mitochondrion. Nucleus. Note=Nuclear envelope.
Sequence:
MLVVGLTGGIACGKSTVSRRLRDKYKLPIVDADKIARQVVEPGQNAYDQIVLYFKDKIPNLLLEDGHLNREALGKWVFSHKEDLQALNGITHPAIRYAMFKEIGYYYLKGYRMCVLDVPLLFEGNLDSICGVTVSVICTQELQLERLMTRNPELSEEDAKNRLNSQMSTEERMARSDYILQNNSTLVDLYEQIESVVKKIQPSKLRTVLEYFPPFGAVSASSIVMSRLLMKKLQNKKSSAV
The following text describes a protein:
Function:
Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.
Sequence:
MVDREPGTPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHFLLSTNDKTIKLWKVFDKSLKVVAENNLSNELTPAGAVGGGGAPRAPRLSFKDASALKLPRMTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPISCNWFMYASSKGTIKLADMRQRALCDEHSKLFEQEEDASSRSFFSEIISSISDVRFSHDGRYIVSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAENVMTGSYNNNFMIYPTDPSKETEIVLQADKSAFKAKKVGVPTPMNKNGKKNGSRAGSPAGPGSRMKKETDADQIDFNKKILHMSWHPYEDSIAIAATNNVSILALHFPSCYHSCDFAKVLIQSEQLFVFSAL
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Sequence:
MVSVTDLKDYSLCKVIPWIRKKMGWKEPITNSQRIAKNVNLKEIVRDFPEPKYYEVHLRDKDSGLNGIVDVLTEDSVIEIKAFYRRFYNHFRIQLLAYAYLAERNGFRVRNTVLLMNKERKINIEVRKEHVEYIGKVVNELVESLEDDSPPVVNPSPLLCKACQYRRVCSVSVLL
The following text describes a protein:
Function:
Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells. Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling. Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells. Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion. Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane. Note=Localized along the oolemma microvilli of unfertilized oocytes.
Sequence:
MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSILVLAAAAALLHYARARRKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNPIYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEENYENVPRVLLASDH
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLIWNILNKYNFKSKIYKDVNLSHYTSFKIGGKVDLFIIPYSWEELILILQILKENNIPTKVMGQGTNILAPDEGIKGAVIRLNQNLGKINFVDNSHLEVESGCLISKLISFMVEKNMGGLEFMMGIPGTIGGAVMGNAGAFRKAIGDFVEGVYVLNEHFEEMFLGKKELNFNYRSSNIPKDWIIKKVLLRLEEKPKEESLKEIKFFIKERSKKLPKYPSAGSVFKNPKEGPAGYFIDNLGFRGFRIGDAMVSYEHANTIINVGRARSKDVLEIINIIKDKVKEAYGIDLEPEIIIW
The following text describes a protein:
Function:
Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLISARRLRRCQFLQLLASCFVLSLMALLVQEDNSLISHVKSYSYRYLINSYDFVNVSLSIPRDRLDGAASYRYLLNNRHICLNEDVLLLLFVKTAPENRRRRDAIRNTWGNEDFIRSQYDANIKVVFALGAEGDPVKSREIQQDLVNENKRFKDLIQQDFSDTFHNLTLKLLLQFGWVNSFCPSAKFIMSADDDIFVHTPNLVSYLKSLPIETQDFWIGRVHRGSPPIRRKTSKYYVPYEMYPWSSYPDYTAGAAYVVSRDVAAKVYEASQTLNTSLYIDDVFMGICANKMGLVPQYHVFFSGEGKSPYHPCIYNKMMTSHGHLDDLDYLWRQAIDPNVKSISSGFWGNLYCRFVNIMLLCRISYVDTYPCSAAWS
The following text describes a protein:
Function:
Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain. Required for faithful chromosome segregation during mitosis (By similarity). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.
Subcellular Localization:
[C-terminal 80 kDa form]: Secreted. Note=Secreted in primary hepatocyte-conditioned media; Cytoplasm, cytoskeleton. Golgi apparatus membrane. Midbody. Note=Co-localizes with CLASP2 in microtubules.
Domain:
Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain.
Sequence:
METPAGESSARGYGPPPAPAPAAERKKSHRAPSPARPKDVAGWSLAKGRRGTGPGSATACGTASSARPDKKGRAVAPGTRGTGPRVAGVRTGVRAKGRPRPGTGPRPPPPPPSLTDSSSEVSDCASEEARQLGLELALSSDAESAAGGPAGTRTGQPPQPAQSGQQPPRPPASPDEPSVAASSVGSSRLPLSASLAFSDLTEEMLDCGPGGLVRELEELRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRMRLEEENEGLRQRLIETELAKQVLQTELDRPREHSLKKRGTRSLGKTDKKPTAQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDAALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGGGPEARLAFSSLGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKYRSEHELDVTLSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETLEPHAARLCRAREAEALPGLREQAALVSKAIDVLVADANGFSVGLRLCLDNECADLRLHEAPDNSEGPRDAKLIHAILVRLSVLQQELNAFTRKADVALGSSGKEQPEPFPALPALGSQGPAKEIMLSKDLGSDFQPPDFRDLLEWEPRIREAFRTGDLESKPDPSRNFRPYRAEDNDSYASEIKDLQLVLAEAHDSLRGLQEQLSQERQLRKEEADSFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNILVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEEDDFLEVNSMKELYLLMEEEEMNAQHSDNKACTGESWTQNTPNECIKTLADMKVTLKELCWLLQDERRGLTELQQQFAKAKATWETERAELKGHASQMELKAGKGASERPGPDWKAALQREREEQQHLLAESYSAVMELTRQLQLSERHWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAAEPWVLKHSDMEKQDNSWKEARSEKTHDKEGVSEAELGGTGLKRTKSVSSMSEFESLLDCSPYLAGGDARNKKLPNGPAFAFVSTEPVEPEKDAKEKAGLSTRDCSHIGSLACQEPAGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKILIEPGFLFTTAKPKESAEADGLAESSYSRWLCNFSRQRLDGGSGASTSGSGPAFPALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKNTSSQTVGVATVGTQTIRTVSVGLQTDPPRSSLHSKSWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSTKDRSLWNLHQGKQNGSAWARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSEARTKPEPPKYGIVQEFFRNVCGRAPSPTTAAGEESCKKPEPLSPASYHQPEGVSRILNKKAAKAGGSEEVRPTMLSQVGKDGILRDGDGSLILPSEDAVCDCSAQSLASCFIRPSRNTIRHSPSKCRLHPSESGWGGEERAAPQ
The following text describes a protein:
Function:
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.
Subcellular Localization:
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MAMDSSLQARLFPGLAIKIQRSNGLIHSANVRTVNLEKSCVSVEWAEGGATKGKEIDFDDVAAINPELLQLLPLHPKDNLPLQENVTIQKQKRRSVNSKIPAPKESLRTRSTRMSTVSELRVTAQENDMEVELPAAANTRKQFSVPPTHPRPSCPAVAEIPSRMVSEEVEEQVHSIRGSSSANPVNSVRRKSCIVKEVEKMKNKREEKKAQNSEMRMKRAQEYDSSFPNWEFARMIKEFRATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASRDVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGKQQVQVVGLQEHLVNSADDVIKMIDMGSACRTSGQTFANSNSSRSHACFQILLRAKGRMHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQLIQMETEEMEACSNGALIPGNLSKEEEELSSQMSSFNEAMTQIRELEERAVEELKEIIQQGPDWLELSEMTEQPDYDLETFVNKAEFALAQQAKHFSALRDVIKALRLAMQLEEQASRQISSKKRPQ
The following text describes a protein:
Function:
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).
Miscellaneous:
MISCELLANEOUS: Proxyfan acts as a potent neutral antagonist while thioperamide, ciproxifan and FUB465 act as potent inverse agonists.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK