lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import.
Subcellular Localization:
Cytoplasm, perinuclear region. Mitochondrion inner membrane. Mitochondrion intermembrane space. Nucleus.
Sequence:
MLRWGSAAATGLGQKLVPLVQTICVRGQKQKSRFPDSIHSWMPHWILDVSYQYRKVLERVNPTRISKSLGNLLQRWHIPVEFQMTRQMASSGASGNKIDKSMLVLIVGLSSMGAGAYAYMTVKEDQKRYDERISGLGLTPEEKERRDSLSVPETRAQIKAPTHAPFLLIGGGTAAFAAARSIRARDPGARVLIISEDPELPYMRPPLSKELWFSDDPNVTNTLRFKQWNEKCLIATGGTPRNLSAIDRAGPEVKSRTTLFRKIGDYRSLEKISREVSSITVIGGGFLGSELACALARKARTLGTEVIQLFPEKGNMGKILPEYLSNWTTEKVRKEGVKVMPNAVVQAVGVKSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEVDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDGSLPTVGVFAKATAKDTPKSATEQSGTGIRSESETESEASDIDIPPSDAKTPQSLIKGEDFGKGVIFYLRDKVVVGILLWNIFNRMPIARKIIKDGEEHEDLNEVAKLFNIHED
The following text describes a protein:
Function:
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage.
Domain:
The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
Sequence:
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKESCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR
The following text describes a protein:
Function:
Involved in the terminal step of the biosynthesis of quinolone which in addition to serve as a potent signal for quorum sensing, chelates iron and promotes the formation of membrane vesicles (MVs). Catalyzes the hydroxylation of 2-heptyl-4-quinolone (C7-HHQ) to yield 2-heptyl-3-hydroxy-4-quinolone (PQS).
Sequence:
MTVLIQGAGIAGLALAREFTKAGIDWLLVERASEIRPIGTGITLASNALTALSSTLDLDRLFRRGMPLAGINVYAHDGSMLMSMPSSLGGNSRGGLALQRHELHAALLEGLDESRIRVGVSIVQILDGLDHERVTLSDGTVHDCSLVVGADGIRSSVRRYVWPEATLRHSGETCWRLVVPHRLEDAELAGEVWGHGKRLGFIQISPREMYVYATLKVRREEPEDEEGFVTPQRLAAHYADFDGIGASIARLIPSATTLVHNDLEELAGASWCRGRVVLIGDAAHAMTPNLGQGAAMALEDAFLLARLWCLAPRAETLILFQQQREARIEFIRKQSWIVGRLGQWESPWSVWLRNTLVRLVPNASRRRLHQRLFTGVGEMAAQ
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEVRRRKIDVLKAQKNGYESGPPSRQSSQPSSRASSRTRNKHSSSTLSLSGLTMKVQKKPAGPPANSKTPFLHIKPVHTCCSTSMLSRDYDGSNPSFKGFKNIGMIILIVGNLRLAFENYLKYGISNPFFDPKITPSEWQLSGLLIVVAYAHILMAYAIESAAKLLFLSSKHHYMAVGLLHTMNTLSSISLLSYVVYYYLPNPVAGTIVEFVAVILSLKLASYALTNSDLRKAAIHAQKLDKTQDDNEKESTSSSSSSDDAETLADIDVIPAYYAQLPYPQNVTLSNLLYFWFAPTLVYQPVYPKTERIRPKHVIRNLFELVSLCMLIQFLIFQYAYPIMQSCLALFFQPKLDYANISERLMKLASVSMMVWLIGFYAFFQNGLNLIAELTCFGNRTFYQQWWNSRSIGQYWTLWNKPVNQYFRHHVYVPLLARGMSRFNASVVVFFFSAVIHELLVGIPTHNIIGAAFFGMMSQVPLIMATENLQHINSSLGPFLGNCAFWFTFFLGQPTCAFLYYLAYNYKQNQ
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAASSFAELIRPMINTACTLGISYVKHCPSTSDRFVVPKSLTIKFGFWIVTLLAIGCYSLIRTKQDVLERSQKESYFDYVLFFVSNMMLVLTVLQMVYYGYTRKHVQLELLNSTIDIERELTVLLKRKINYGVIARFTKWLTIWTIFFYVIIMHTLYVFDHLRYNTFILMYIETLLLLYANNCIEFTIIICCTTQMTLCRYLKDLMNALETKKLPLASELYMYFKLIDRITVLINFHLSQIYGSFVVFHCMYVLFESASIWFSFLSASSSMQFQIVNEESNLMLVSYILWFLSDSKNVLLVAISSSLLQQKVEETALCTRHFDDYRLQNTRAAKQIQNFLLKNLHQKKKFSACGFFDIDNTVIYMVFSSIVTYLVILIQFKQLETDLTQAGDGYNVTSNVSTVQP
The following text describes a protein:
Function:
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced by alternative promoter usage.
Sequence:
MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
The following text describes a protein:
Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MELEISQLVDKIVRCIPNYPKPGINFRDICPLLKNIEALNKVIEYFAGKINFEFDYIAGLESRGFLFGILLSQRLNKGFIPIRKKNKLPGEKISLEYKLEYGSDIIEIQADAFEPGSKILICDDLLATGGTAVAANELIHKAQGNTVGYVFVIELKDLKGKDRFDPKVPVIVALSD
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYFSRRDIRFLRPIFAVCRLFALVPYYNFEKFSLEHQLWQKIQAWTYLILLTTWTVISASTRIKSFKFLTIGVGITTDTIDRVFTVAIPFVGIANSCILNQDKWRLLNNNFQQIDKIFKTRDDRVKVYQAPVLQLFLYIFTYLSVTCYVTYAWSPIDHTESNIINDMCSLYYILQITLIVNYALALKNRFKELQKYLKIETSCRYVGTLYRILTTMMEMVNDIFGWTLILILAKCITSSLSSLYTCIAGYEFNANFTISYILFALFNTFGTILLIMTCSGVHSESQKLVGVCYEYQDRFSDESKKRRELLRLAQQVNANIAQITAANFFDISRSTFLGILATITTYFIVIIEFGF
The following text describes a protein:
Function:
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity).
Subcellular Localization:
Virion. Host cytoplasm. Note=Tightly bound in the nucleocapsid.
Sequence:
MQQPRGRSRTRNHQVTPTIYHETQLPSKPHYTNYHPRARSMSSTRSSAESSPTNHIPRARPPSTFNLSKPPPPPKDMCRNMKIGLPCADPTCNRDHDLDNLTNRELLLLMARKMLPNTDKTFRSPQDCGSPSLSKGLSKDKQEQTKDVLTLENLGHILSYLHRSEIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHMNHENLPQDQNGVIKQTYTGIHLDKGGQFEAALWQGWDKRSISLFVQAALYVMNNIPCESSISVQASYDHFILPQSQGKGQ
The following text describes a protein:
Function:
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MNSKAMQALIFLGFLATSCLAQAPAPAPTTVTPPPTALPPVTAETPSPIASPPVPVNEPTPAPTTSPTTSPVASPPQTDAPAPGPSAGLTPTSSPAPGPDGAADAPSAAWANKAFLVGTAVAGALYAVVLA
The following text describes a protein:
Function:
Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
Sequence:
MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
The following text describes a protein:
Function:
Transpeptidase that anchors surface proteins to the cell wall (Probable). Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable). Catalyzes a cell wall sorting reaction in which a surface protein with the consensus sorting signal NP(Q/K)(T/S)(N/G/S)(D/A) is cleaved between the fourth and fifth residues, and the fourth position is linked to the cell wall (Probable). This is not the major sortase in Listeria, it seems to anchor only 2 proteins, Hbp2 (SvpA) and Hbp1.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MKIKSFLGKSLTLVVLGVFLFSGWKIGMELYENKHNQTILDDAKAVYTKDAATTNVNGEVRDELRDLQKLNKDMVGWLTIIDTEIDYPILQSKDNDYYLHHNYKNEKARAGSIFKDYRNTNEFLDKNTIIYGHNMKDGSMFADLRKYLDKDFLVAHPTFSYESGLTNYEVEIFAVYETTTDFYYIETEFPETTDFEDYLQKVKQQSVYTSNVKVSGKDRIITLSTCDTEKDYEKGRMVIQGKLVTK
The following text describes a protein:
Function:
Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAPTGLLVAGASFLAFRGLHWGLRRLPTPESAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTLGKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLLLLSRQAPSLAFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILGIRILVNDVLQSRPHPPSPGHEKTRGTRTRRDNGPVTSNSSTLSLKD
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVLVTAAWPYVNSVPHLGNLIGSILSADVFARYARLRYGKENVLFVSGSDEHGTPIEIEAIKRKVNPKELTDQAHEYDRHLFLNVWKISFDNYTRTESEIHKKFVREFLLKLTKYIKVSEDEIPYCENDKLYLPDRFVKGTCPYCGFEDARGDQCDNCGKLLTPSLLVNPKCSICGKTPVFKKTKHWFFDLSEFNDKIRGWISSSNEMPDNVKSVALSWVGEGLKPRSITRDNKWGIPAPFEGAQDKSIYVWFEALLGYISAVIEYFERKGDQEKWKEYWFGPNIKSYYFIGKDNIPFHAVILPAMLMASEEEYHLPDVIAATEYLLYEGQKFSKSRKIGVWIDEAPELMDVEYWRFVLIRLRPEEKDTNFTWRETVRIVNTELNDDIGNYVNRVLSMVNRYYSGIVPEFKIDILDDNDRKIISLINETPKVVGDLFEKGKLKAGTEEMLKFVRECNAYLNMKAPWDLYKSGKEIELKNTLYIGTNSVKTIAILLYPLMPSHAQKIYEMLNMGNIENEKWDVASTLSVNPGHKIGKVNVLFKKLEPEFESKIKDKLEKIRKDIEKIRPTLLK
The following text describes a protein:
Function:
May organize microtubules by mediating spindle positioning and movement in the budding process. Potential target of the RHO family members (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Sequence:
MDSSPNKKTYRYPRRSLSLHARDRVSEARKLEELNLNDGLVAAGLQLVGVALEKQGTGSHIYMKQKNFSANDVSSSPMVSEEVNGSEMDFNPKCMPQDASLVERMFDELLKDGTFFWGAAYKNLQNISLRRKWLLICKIRSSNHWGKKKVTSSTTYSTHLATNELAENAHFLDGLVRNLSTGGMKLSKALYKLEKFLRKQSFLQLFLKDEIYLTTLIEKTLPLISKELQFVYLRCFKILMNNPLARIRALHSEPLIRWFTELLTDQNSNLKCQLLSMELLLLLTYVEGSTGCELIWDQLSILFTDWLEWFDKILADDIAIHSSLYLNWNQLKIDYSTTFLLLINSILQGFNNKTALEILNFLKKNNIHNTITFLELAYKDDPNSVVIMEQIKQFKSKESAIFDSMIKTTNDTNSLHPTKDIARIESEPLCLENCLLLKAKDSPVEAPINEIIQSLWKILDSQKPYSESIKLLKLINSLLFYLIDSFQVSTNPSFDETLESAENVDYVFQDSVNKLLDSLQSDEIARRAVTEIDDLNAKISHLNEKLNLVENHDKDHLIAKLDESESLISLKTKEIENLKLQLKATKKRLDQITTHQRLYDQPPSLASSNLSIAGSIIKNNSHGNIIFQNLAKKQQQQQKISLPKRSTSLLKSKRVTSLSSYLTDANNENESQNESEDKSKDSLFQRSTSTINFNIPSMKNITNMQNVSLNSILSELEFSNSLGTQPNYQSSPVLSSVSSSPKLFPRLSSDSLDNGIQLVPEVVKLPQLPPPPPPPPPPPLPQSLLTEAEAKPDGVSCIAAPAPPPLPDLFKTKTCGAVPPPPPPPPLPESLSMNKGPSNHDLVTPPAPPLPNGLLSSSSVSINPTTTDLKPPPTEKRLKQIHWDKVEDIKDTLWEDTFQRQETIKELQTDGIFSQIEDIFKMKSPTKIANKRNAESSIALSSNNGKSSNELKKISFLSRDLAQQFGINLHMFSQLSDMEFVMKVLNCDNDIVQNVNILKFFCKEELVNIPKSMLNKYEPYSQGKDGKAVSDLQRADRIFLELCINLRFYWNARSKSLLTLSTYERDYYDLIFKLQKIDDAISHLNRSPKFKSLMFIITEIGNHMNKRIVKGIKLKSLTKLAFVRSSIDQNVSFLHFIEKVIRIKYPDIYGFVDDLKNIEDLGKISLEHVESECHEFHKKIEDLVTQFQVGKLSKEENLDPRDQIIKKVKFKINRAKTKSELLIGQCKLTLIDLNKLMKYYGEDPKDKESKNEFFQPFIEFLAMFKKCAKENIEKEEMERVYEQRKSLLDMRTSSNKKSNGSDENDGEKVNRDAVDLLISKLREVKKDPEPLRRRKSTKLNEIAINVHEGDVKTRKDEDHVLLERTHAMLNDIQNI
The following text describes a protein:
Function:
Involved in the biosynthesis of L-colitose, a 3,6-dideoxyhexose present in the O-antigen region of lipopolysaccharides (LPS), where it serves as an antigenic determinant and is vital for bacterial defense and survival. Catalyzes the removal of the C3'-hydroxyl group from GDP-4-keto-6-deoxy-D-mannose via a combined transamination-deoxygenation reaction. The catalysis is initiated by a transamination step in which pyridoxal 5'-phosphate (PLP) is converted to pyridoxamine 5'-phosphate (PMP) in the presence of L-glutamate. This coenzyme then forms a Schiff base with GDP-4-keto-6-deoxy-D-mannose and the resulting adduct undergoes a PMP-mediated beta-dehydration reaction to give a sugar enamine intermediate, which after tautomerization and hydrolysis to release ammonia yields GDP-4-keto-3,6-dideoxy-D-mannose as a product.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MRKIMINFPLASSTWDEKELNAIQRIIDSNMFTMGESVKQYEKDFAEYFGSKYSVMVSSGSTANLLMIAALFFTKKPKFKRGDEVIVPAVSWSTTYFPLQQYGLNVRFVDIDKKTLNIDLDKLKSAITEKTKAILAVNLLGNPNDFDAITKITEGKDIFILEDNCESMGARLNGKQAGTYGLMGTFSSFFSHHIATMEGGCVITDDEELYHILLCIRAHGWTRNLPEFNHITGQKSIDPFEESFKFVLPGYNVRPLEMSGAIGIEQLKKLPSFIEMRRKNATIFKELFSSHPYIDIQQETGESSWFGFALILKESSPITRAELVKKLIEAGIECRPIVTGNFLKNKEVLKFFDYTIAGEVTDAEYIDKHGLFVGNHQIDLSEQIKNLFNILKK
The following text describes a protein:
Function:
S-crystallins are structural components of squids and octopi eye lens. Contains relatively little if any GST activity.
Sequence:
MPNYKLVYFNGRGRAETIRLTFVASGIEFEDHRIEQDRWPDMKPKTFAGYLPYLEVDGKVLVESMAIARFVAREGKLAGGCSYEQAQIDSIVDILSNMAEKAVKIVYYSTGEEKKNLEKEFIETVLPDVFKLLEKFLQDKQFLVGDKLSLADLHFHTVLECVGLFAKDWPLLSGKMKRLFDRVESEPRIAEYLKNRPVTPF
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTIAYYARLNKIAIWNSFMIVFAFWKGSIWKIILDEVGTWYLIYLCIAGIYRFYLSAEQQEIFSSFIRDLQDKHNVCVPMQFMLGYFIGMVGERWGESFENVSYIEKVALSVAAFIPGVVNIHNRRNIIRYMVLSQILGIRQISALVKKRFPNNDALVTAGLLHETERKKLEKVPCAVYAESFVPIIWALKILQKYEEAEERTFKADNPREEFGGTGVYDTVYAEITEFHEKTATLSTYDTTPIPLAYSQIVIFSVRLYFFICLFTRQHLDMDDTYLELVFSLFPLLTIMQFIFMVGCMKVSSVLINPMGEDDDNYECNYVFDRNLFVGMEIVGWVKENPAKTHPDLDGRNIIDIDNRPYYPKYGDKFDGKNKAYVGSYKHVPFPHKAMSKLPLDAQQVQGKKKRVGTCLSCNLTLKEPNTSAEEPEAAIVASPGAVVLHVQPQ
The following text describes a protein:
Function:
Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system). Can also transport maltose at a lesser rate. May also transport biotin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MATSDQDRRHRVTRNRPPIARPSTSSSRPVVSPPRSKVSKRVLLRVASVACGIQFGWALQLSLLTPYVQELGIPHAWASVIWLCGPLSGLFVQPLVGHSSDRCTSKYGRRRPFIVAGAVAISISVMVIGHAADIGWAFGDREGKIKPRAIVAFVLGFWILDVANNMTQGPCRALLADLTENDNRRTRVANGYFSLFMAVGNVLGYATGSYNGWYKIFTFTKTVACNVECANLKSAFYIDVVFIAITTILSVSAAHEVPLASLASEAHGQTSGTDEAFLSEIFGTFRYFPGNVWIILLVTALTWIGWFPFILFDTDWMGREIYGGEPNIGTSYSAGVSMGALGLMLNSVFLGITSVLMEKLCRKWGAGFVWGISNILMAICFLGMIITSFVASHLGYIGHEQPPASIVFAAVLIFTILGIPLAITYSVPYALISIRIESLGLGQGLSLGVLNLAIVIPQVIVSVGSGPWDQLFGGGNSPALAVGAATGFIGGIVAILALPRTRIQKPIPLP
The following text describes a protein:
Function:
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MATDGGVWIGSVYLFVQSTRKEVVLSAVYASPQKPSVFGALKLSLAEATGNQPGLEVLKIHCSEPQLIVQLKFCQQECCRRFLRSYREGALLEALQSHLQLVLGCSPGPLLLELKVGSEQLDGLMQEEERCLELIYGEKPDRLRDEEIADLEDALRNLTCRQEGKEATPSPGDWEPTPTTGGKPPVAPTTEDTFVFQGQHVANRPLSLEDQQRFARLVGKKWKKVGRSLQRSCRALRDPVIDALAYEYEREGLYEQAYQLLLHFVRAEGRRATLQRLVEALEENSLTSLAEDLLGLQHQESEIS
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MASDSDVDEDELLQMALQEQAARDLSHQRPPAANKPVVNLVRPPAPNARGGKGAAAKARQPSRGGDEDDDSEVELLSISSGDEDDNPRARGPPPPRGGGGGRAGARRAASRDDGDFDDEEPRSWKRVDEAELARRVREMREAKVAPNIQELDQKAAAAAAAARKALTTVQTLPKGVEVLDPLGLGVMDNKSLRLITDASVSSPVSREKSQGLDPSMRDKVIYSSPNFDPKVFLSWVHKDTSAADLEAGALTLKTDLKGRTQQKKQLVKENFDCFVSCKTTIDDIESKLRQIEEDPEGAGTAHLYSVTQKISGVANRAFEPLFERQAQAEKIRSVQGMLQRFRTLFNLPSAIRGNIRKGEYDLAVREYQKAKSIVLPSHVGILKRVLEEVEKVMQEFRGMLYKSMEDPHLDLAELENIVRLLLELEPETDPVWHYLNIQNSRIHGLFEKCTQDHESRMEVLQNKIHEKVLSDSKWRQLQQDSNKSLEVDSAIGDSPRADQLSTNFMAEEADSLRATYIRRLTSVLIQHVPAFWRLALSVFSGKFAKAASGNVVSDSDMNAKPAANKNDDKSGEVKYTNHTLDEVASMVRATISAFDTKVQSTFRDFEECNILCPYMSDTIKEIAKACQTLEGKDSSPTAVKMLRTLHFEMTKLYILRLCSWMRATTKKISKDETWVTLSTLERNKSPYAISCMPLEFRDITISAMDRIDTMILNLMSETAKSYDISQPLQEINESVRLAFLNSFLDFAGYLERFVGELTENRPNKENNYVQNGYINGTRETPANTDGDLHKKLLVVLSNIGYCKAELSEELYTKYRHIWSPVRNNDERSSDMRDLMTSFSALEEKVLDQYTFAKSNLIRSAAQSYLLDSGIYWGAAPMVKGIRDATLDLLHILVAVHAEVYSGARPLLEKTMKILVEGLVDIFLSVFHENKTKDIRLLDANGFCQLMLELEYFETVLQTYFSPEAQQAMKSLQENLLEKACESVAEAMENPGHQRRPTRGSEDTASDGQPSVSPDDLLVLAQQYSSDLLQGELERTRLNIACFMESTLQSTGAPAGSKPGAYSSYQAQVPQHAPVQTSSPSFRRQQTGTSSPVVSRRRR
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAQEKKENQSVLVKGYLTLYNTAQFAGWTYIFVQFIQHFAVHGQSLDTLWSRVGQATFFFQMLAILEVVHAMVGIVPSNVAMTFLQVFGRCMIVAGAIEGTPTGQKSPGLPLALFCWSLTEIIRYSYYVAHLLLPAVPSLLVWLRYTIFIPMYPCGFLGELLCSYWAQSYIRDTGKWSVELPNRFNFSFSFYYFIWIMAVCYMPLFPQMYLHMFAQRRKVFGRGTQTRQKLTKAN
The following text describes a protein:
Function:
Binds to mitochondrial DNA (mtDNA) and plays a role in the maintenance of mtDNA levels. May also associate with telomeric DNA, binding to at least two telomeric repeats of the sequence 5'-TTTAGGG-3' (Probable).
Subcellular Localization:
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Nucleus. Chromosome, telomere. Note=Mainly localizes to telomeres in mature oocytes and embryonic cells.
Sequence:
MLGTISMRFFATKVVAPRASVAASTPQVPLGMNINPYAMFIKENFKANTSDMKRTDLMKELSGKWKALSISEKDKYTELSKNYNAQKLDDFMKLSTEEQKKLVDSAKEKKAERASRRHAKERREKRKQSGRPSVPPSAYALFIKEKLSGAGMESKEKMKEAVAQWKAFTDSQKKKYTDEAKKLKDEYHVVLQKWEAEQKENADQ
The following text describes a protein:
Function:
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNYTSVNKIRLWVLIVFLILYNIKCICENISDLKKRLCFNNFSNSKKKIKKKWLAKKKKNYLTIWKNKTYTTKRRNGYGKIEYKREENKKDDYNFMNTSLYLNYISNVKNFLFNKNNNKKNKIYYHKCKKSNIIEAKINDNDTLLSDEEFRNDVDRNDKEYYNIKKEYSENVCNQNRINDLSNCSVSSNNNILNECSSEVKKEMNYPLHNELYDNLNDNTIGHLKSEKCKEKYIRNFCILAHIDSGKSTLADRFLELTNTIKKKRMQEQFLDMMCLEREKGITIKLKAVRMHYNNYVFNLIDTPGHFDFYHEVKRSLNVCEGAILLIDGGKGIQSQTLNIFFELKKHDIKIIPVINKIDLSTCLYDKIKDDLINKFNFKENEILKISAKYGKNVKMLFQRIISDIPPPINTINSFFRGVVFDSFFDQYKGVVLIIKVLNGELRKKTEIFFINSAKSYIIQEVGYLVPEMKPTDVISQGDIAYVCSNIRNCDDIQISETIVNKDIIKKNNHNEFVINFKKINLGRDKNIMQRLSDEGKQYLTHHNKGEIKGDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDENGQVKCDKNKGEIKSFQYNEVKVDERYERNKEEIIYDHEHKKEGIFNIHKNDDLIKENIKEKENFSCSIQGNDNAIPILKKTDINIKSIAANKIEASYPSVYCNIYCVNDKKSNELEMSLNKLKLNDSSFSFKKYICETLGKGFKCGFNGLLHLNIIQERIKREYNIDTIVTAPSVNYLIRVKEKYMDKRLKEKLLEKNFDIQNMHIEQMDKTSSDDCFFFMTSNVNDIPTKNVVHSIYEPYVKTNIITPEIYQKYIMNECFKRRGIFIKKEIMNDQIIFLFEMPLSEILINFLDQIKSSTKGYGSMSYENIIIYKPSELYKIHIYINKKKIDSLSFLAHKRNYEDKSRKLVSKLKTLINPHQFLIIIQAALESKIFVSEKIKPLKKNVTAKCYGGDITRRRKLIEKQNEGKKKMFEIGKVKLPPNIFTKLFDIKSE