lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Essential for the beta oxidation of unsaturated fatty acids.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCTLEKRGDLFLLTLTGEDEHRFHPDTIASVLSLLEQAKSQSTKGSVLITTGHGKFFSNGFDLAWAQSAGHGAIKRMHQMVKSFKPVLAALLDLPMPTIAALNGHAAASGLMFALSHDYVFMRKDRGVLYMSEVDIGLPVPDYFSALVVAKVGSGIARRELLLSGKKLKGEEAVALGIVDSAAHDSAEGVVEATVSLGESLAAKKWNGEVYATIRKSLYPELCRMVDLTANNLATHNL
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MTLSFAERVAQLDTAETAPTRVDLKLLANLGPESVYIFWEQWQRFSLDRRRHIMHLLAELAEEQIQLDYRPVFRACLADHDAEIRVLAIEGLWEDDHEQMMDRLIQMIHDPAGEVRAAAVISLARFAYRAEIGELSLSAAQRLLNALLQTASDPEQPSEVRRRAVEALGYFADSQEAQALVARAYSMDDIYMRESAVLAMGRSMRPQWFPYILRELKSPSPSLRYEAARAVGEIGEDGRELLPALLPLVDDEDTEIALAAIWALGQVGGSDARRILKRIARSRDEVRAQVAQDALAELDLDTL
The following text describes a protein:
Function:
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
Subcellular Localization:
Mitochondrion. Membrane; Multi-pass membrane protein.
Sequence:
MSPGIVSQEVNGRQEPTEAARDERHGRRRRVAVIGAGLVGSLAALNFARMGNHVDLYEYREDIRQALVVQGRSINLALSQRGRKALAAVGLEQEVLATAIPMRGRMLHDVRGNSSVVLYDPINNQCLYSVGRRQLNEVLLNACDKLPNIRCHFEHKLTSANLREGSMEFRNPAKEAVAAHADLIVGCDGAFSSVRQNNVRLPGFNYSQEYIETGYLELCIPSKSGDFQMPANYLHIWPRNTFMMIALPNQDKSFTVTLSMPFEIFAGIQNQNDLLEFFKLNFRDALPLIGEQQLIKDFFKTRPQFLVSIKCRPYHYADKALILGDAAHAMVPYYGQGMNAGMEDVTLLTDILAKQLPLDETLALFTESRWQDAFAICDLAMYNYVEMRDLTKRWTFRLRKWLDTLLFRLFPGWIPLYNSVSFSSMPYRQCIANRKWQDQLLKRIFGATFLAAIVTGGAIYAQRFL
The following text describes a protein:
Function:
Regulates exocytosis by functioning as a GAP for ypt2.
Subcellular Localization:
Cytoplasm. Membrane; Multi-pass membrane protein.
Sequence:
MAGITEHSTIMNDANFKEENAHLSDASIHFGSSEQDKTPSDYELDDVLDLYNDTTEDDADDADDVNNYIMSPSSSLSSESEHALDALVYPIYSHHNILEHENNSDYASITPSNHPAFTSCAYLQNPVVDSNNEYESKFRLSLEIPPTDFLSTSTELSKRESCLSTETSSSKFSAVTAATITNETQSEKRSSQTDPSLPFKTNSLNCDVTYEEGPLTKKLRGPKKYKPSHSSWDIYGFKKANQFYTVDQYNTWYGPYSRYLERREQRWKLFLQENGIDYIHQSPSIFPSRSAKTQRFIRKGIPPEYRGNAWFYYSGGYELLQRNPKLYETLWRCACIKKPSDSDLIERDLYRTFPDNVHFRHKSKHSRNSSDASEHSSEEPDVPMISKLRRVLMTFATYLPENGYCQSLNFLAGFFLLFMSEEKAFWMLVITCRKYLPKMHDANLEGANIDQSVLMASVRESLPAVWSRISLNFDGIPVNDIVAKLPPITLVTAAWFMSAFVGILPTETALRVWDCFFYEGSKVLFMTALCILRLGEDDIKSKSEQTEVFQVIQDLPKSLLDANAFLSLCFRRNFRRTPSQKDIERRREKVAKKRNSSASKLEMSDSSKHHLSRSSSRFSKSHIISQLHNHLKKST
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MNVLKQQERDSDHQTGETKMKGHQVEGSGRINALGRALTKILRHRAAELNLEMRSDGFCKVADLLRLDFTTRSKVPLSAHTVEEVLQAVEQDSKERLATMVDESGELLIRANQGHTLLDAVCSDDLLEEISIDDNLLAVCVHGTFKHALPGILRDGLKTMGRKHVHFAAGLPGAGEVVSGMRGNCDALVFVNAARAMADGMKFYVSKNGVVLTEGFEQCVPAKYFDKIVEWPSNVLLHDREEITE
The following text describes a protein:
Function:
Required for the Mettl1-dependent formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the Mettl1-wuho methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for binding of nanos mRNA and repression of translation by the mei-P26-bgcn-bam-sxl complex. May cooperate with mei-P26 and nanos to derepress the BMP signaling pathway. May cooperate with mei-P26 to suppress expression of a subset of microRNAs. May cooperate with mei-P26 to regulate bam expression levels in germline cells during gametogenesis. Required to promote mitosis to meiosis transition during gametogenesis. May regulate germline cell division in part by regulating ribosome biogenesis; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MATASSSNAGLTLVSAGSFVHLLDVDGRILSSVDVLPISKAVPLSKSSDGTERKEQLKFHDDFQLLTTSFANDSGLVAVGTSAKTVVIFDLKRESLVERRTFRIPKTPTALVFDRADAFIIVADRAGVVRKYSVDVTAKENKEHIDEDDTDETDFEGDFMCSAISMMLDVKFSPCGKYLLVTDRDEKMRVHRYPQTFVLHQMCMAHKDYVNTVCTATVGERQLAFTAGGDGVIIAWDYMEGVEVGRSEPFGAVRRLRVVQEGSVTRLVVLLNNSSSVVELTVTDGEKIEFKEVKKIEIEGRVMDITVPKEGQVAFVSSTGLGVVTLSDSSIVWSDVSEEHKKTLGEVKDPIPDMTKKVAFDNMNEYLQRKQKKLEGRNKKRKNGNESISEPPLKRVEEDNEDTVEETEVTVAE
The following text describes a protein:
Function:
[Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'; [Isoform 2]: Catalytically inactive; [Isoform 3]: Catalytically inactive; [Isoform 4]: Catalytically inactive.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In spermatozoa, present in the sperm head and in the flagellum.
Sequence:
MGKGDTSETASATPAYRSVMEEYGYEVGKIIGHGSYGTVYEAYYTKQKVMVAVKIISKKKASEDYLNKFLPREIQVMKVLRHKYLINFYQAIETTSRVYIILELAQGGDVLEWIQRYGACAETLAGKWFSQMALGIAYLHSKGIVHRDLKLENLLLDKRENVKISDFGFAKMVPSSQPVHSSPSYRQMNSLSHLSQTYCGSFAYACPEILLGLPYNPFLSDTWSMGVILYTLVVARLPFDDTNLKKLLRETQKEVTFPANLTISQECKNLILQLLRQSTKRATILDVLRDPWMLKFQPEQPSNEIRLLEAMYQPTSSAKRHQSLEITT
The following text describes a protein:
Function:
Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
KMAEAVKVIVRCRPLNQREIKLNCNVCLEMVEERGFCCIRKPGSQADQAPKQFTFDGAYYTSSTTEQIYNDIAYPLVEGVVEGYNGTVFAYGQTGCGKFSMQGVDDPVTQRGIIPRAFQHIFESISVAENTKYLVHASYLEIYNEEVRDLLSKQIKDKLELKEHPDRGVYVKDLLKQPVSNVAECEQIMAFGWKNRSVGATLMNADSSRSHSIFTIYLEACDTGIDGGDHIRAGKLNLVDLAGSERQSKTGSTGERLKEATKINLSLSALGNVISALVDGKSKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIKNKPHINEDPKDALLREYQEEIKKLRGLLVGQLGPDGIKALLEGQSPVPKPKQESETSEKKSSTGDQDSDKMKKV
The following text describes a protein:
Function:
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
Subcellular Localization:
Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane.
Sequence:
MGCLWGLALPLFFFCWEVGVSGSSAGPSTRRADTAMTTDDTEVPAMTLAPGHAALETQTLSAETSSRASTPAGPIPEAETRGAKRISPARETRSFTKTSPNFMVLIATSVETSAASGSPEGAGMTTVQTITGSDPREAIFDTLCTDDSSEEAKTLTMDILTLAHTSTEAKGLSSESSASSDSPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGLHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSWSPGSDVTLLAEALVTVTNIEVINCSITEIETTTSSIPGASDTDLIPTEGVKASSTSDPPALPDSTEAKPHITEVTASAETLSTAGTTESAAPDATVGTPLPTNSATEREVTAPGATTLSGALVTVSRNPLEETSALSVETPSYVKVSGAAPVSIEAGSAVGKTTSFAGSSASSYSPSEAALKNFTPSETPTMDIATKGPFPTSRDPLPSVPPTTTNSSRGTNSTLAKITTSAKTTMKPPTATPTTARTRPTTDVSAGENGGFLLLRLSVASPEDLTDPRVAERLMQQLHRELHAHAPHFQVSLLRVRRG
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSVLSPFVFWAQNEKTVFLKVDLKDVKDPNITLECHKLQFQSKGVGARGLNEYAFAIDFYSNIDAEKSVHKITDNRVDFTIIKTEKGWWPRLMTQTQKPIWLKIDHDRFQAEDMDEEVADVMQDYPNLYDKLQREEFGYKKEDFKKVYLTLYNLFMYVGFMYVVCVLSVRYIKDGSDSFPGTYAAVGSAMCFLQLIQILEVMHPLFGYVRGGAFIPALQVGGRIFVLILMLELEPRLQTMPVVFYLFMTWAAIEIIRYPYYMSQLLKKENGLLTWLRYTAWIVLYPIGFVCEGVIIFRNLIFMEQDNTWSVTISSPFEFTLKFATVLRLYLLIGMIPGLYTLMSHMYKARKLKIGPVTVKKNKIKKAQ
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MNDIKNIEQRLEIFRKAIFTEESSDFKGVVLATSTEKPNLYSVDDAIFRWIYGVFVTNSYLIITPDKLVTLCKDDKASDAIAAARTPEKVIIDQLKGSIADQVKIYANGRLFGSENAIADSDLSSLSLTDKTYDLEGVLIVHLDVELARIRNAARVADGALTKVFKLQMEQIIESSDTISLKSLSNDTRKDLNNPSKVNPKLNPSDVEPAFRPAIRCGSNFDIDFPPTIGEGNLTTDFVNATIGINFKSYCACVGRTYIINGSDDVKRAYKSLVKAKQDAFEQCKAGNTLGAIYRAFVKGLDEQYQQYVPHSIGGFCGTYAISRRHLITDDSEEKIPNNCSIILALGLKGVKIGDQPPFSLSLVDTVQIADGEDGVKFATNAKDRYKLISYKLSNEDQDSILQEMLNDQRPMYERTRNKTGSGTKKDEEDPEMLAYFESIKNQRKSTSSSTSSKNKDDDSDNTQYTSFDNMSDLTTRGVTTIEIIKPRWTVLLPMYGRLVPFHINTIKSAKASTSTDSTESKLDINFNIPKATDSETFKYFIKELTFSQKGNQMFDQIAKDINSMRSHFTKLLKRKQEEKTLYKGEDLIPLQAGPGKNIPRISGHVHLRPALNGNKTVGTIEAHVNGFRFRSTTHERLDVMYKNIELAIYLPATEDNEMMTLIHFYLKKPITTGKQSSQHITFYKPTGDTSVDVSKQGNSMTDQAELAEEERDRKIRKKINKEFKYFKDLLEDKELGLDNPPKLVVPHKQLGFYGVCSKEMSVIYLLPNAIASVVNSPPFVLMMDRVDIVVFERETLSVTNIDISFILKNLTQEVVQISHVSVTDAKNIKQWLGVLQIPFFSSKNNITWKDVIPNILKKGRAYFESEIGGWKGFFNDEEEEVDSEVEDKTWKDDDDDEGFDGGDDDDDEEFDAAPSDEDEDEDEMPAEDSEDEGKDWRQLDEEAKAADERAKAKRERKKEHHHHHHH
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MVRPPVLGWSHLKSSGLSLLAKQIWGTLRSHLLRPARWCSQVPCAQRRRNDALHPVWKGPASVPGGTRQSPINIRWRDSVYDPQLQPLGVSYNAEACLYVWNTGYLFQVEFDDSTEGSGISGGPLENHYRLKQFHFHWGAVNEWGSEHTVDDRVYPAELHLVHWNAVKYQNYTDAVTGADGLAVVGVFLKDARAALGPFQPSCLLPACQDYWTYPGSLTTPPLSESVTWIIHKKPIEVAQDQAKILEWVAIPSSRGSSQSWDQTLVSCTGSWPRFARSCFLCLVKKRRRW
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MEAFAGTPLKDLIRFSVKENIRNFYKLLGFPASVGGAVSMNAGAFGVEISDFLKEVYFVDWEGKLQKAKRDELSFSYRKSPFPELGIVYKVVFELGKSEENILPKYEKIRRIRKEKQPINFPTSGSTFKNPKGNFAGKLLEEVSLKGFRLKNVGFSEKHANFLVNYGGGTFSEVVDLINIAKERVYENFGIVLEEEVKLIESSGSDGWKVLGA
The following text describes a protein:
Function:
Controls entry of the cell into the asexual developmental program. Required to repress entry into the conidiation program.
Sequence:
MPSTKNANGEGHFPSRIKQFFRINSGSKDHKDRDAHTTSSSHGGAPRADAKTPSGFRQSRFFSVGRLRSTTVVSEGNPLDESMSPTAHANPYFAHQGQPGLRHHNDGSVPPSPPDTPSLKVDGPEGSQQPTAATKEELARKLRRVASAPNAQGLFSKGQGNGDRPATAELSKEPLEESKDSNTVGFAEQKPNNDSSTSLAAPDADGLGALPPPIRQSPLAFRRTYSSNSIKVRNVEVGPQSFDKIKLIGKGDVGKVYLVKEKKSGRLYAMKVLSKKEMIKRNKIKRALAEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCSGGEFFRALQTRPGKCIPEDDARFYAAEVTAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSDPGGKPTMIIGKNGTSTSSLPTIDTKSCIANFRTNSFVGTEEYIAPEVIKGSGHTSAVDWWTLGILIYEMLYGTTPFKGKNRNATFANILREDIPFPDHAGAPQISNLCKSLIRKLLIKDENRRLGARAGASDIKTHPFFRTTQWALIRHMKPPIVPNQGRGIDTLNFRNVKESESVDISGSRQMGLKGEPLESGMVTPGENAVDPFEEFNSVTLHHDGDEEYHSDAYEKR
The following text describes a protein:
Function:
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLKQTERRRSWGQRSWSTTEGEDAAQEVGSQSHRRSICSVGGRSGSQASIPPWIEGNYNYYIEEDEDGEEEEELWKDEPAEEEDRQPGEAAATTERAEGGGADTPLVSTTLNVNVGGHSYHLDYTELACYPKTRLGRLATSTSRSRQLGLCDDYEVQTDEYFFDRDPEVFQLIYNFYSSGVLLVRDELCPRSFLEELGYWGVRLKYTPRCCRICFEERRDDLSEQLKIQRELRAQAQAEEAEELFQDMRFYGAQRRRLWNLMEKPFSSVAAKAIGVASSLFVLISVVALALNTVEEMQQQPERGEGGGNPRPFLEHVETLCMAFFTLEFLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTSEDQLHVKGSPREHDLETMGRVGKVGQVLRVMRLLRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLMLFITMGILTFAAAVYSVEHDVQGTNFTSIPHAWWWAAVSISTVGYGDMYPETHLGRLFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTAIRRERGNVEFLQRAGKKIAECLAGSNSQATPRLNS
The following text describes a protein:
Function:
Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death; Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Preautophagosomal structure membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Sequence:
MSGQYSTDQRKYAEPPCLSPTAASLPRAWPPLSGGWVGRRAGFLLSPLPTLWGLTPSPPAAAEPGHQGLECGADAVHGAGGQRGQGAVVMAQFDTEYQRLEASYSDSPPGEEDLLVHVPEGSKSPWHHIENLDLFFSRVYNLHQKNGFTCMLIGEVFELMIQENGSLITILVIAGVFWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEAVFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSGGQTEASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAAGLAQGGLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPLPRDLQGSRHRAEVASALRSFSPLHPGQVPAGRAPSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQAQAEPERHVWHRRESDESGESAPEEGGEGSRASQPIPRSASYPCAAPRPGAPETTALQGGFQRRYGGITDPGTVPRAPSHFSRLPLGGWAEDGQSASRHPEPVPEEGSEDELPPQVHKV
The following text describes a protein:
Function:
Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2).
Miscellaneous:
MISCELLANEOUS: Could be used for serodiagnosis of both pulmonary and extra-pulmonary tuberculosis.
Subcellular Localization:
Secreted. Cell surface.
Sequence:
MEKMSHDPIAADIGTQVSDNALHGVTAGSTALTSVTGLVPAGADEVSAQAATAFTSEGIQLLASNASAQDQLHRAGEAVQDVARTYSQIDDGAAGVFAE
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MGSKIDPFIFSLLYKEISIYALCLPICHLLPFSPQRKFSFIGNLEFSPIPNTHHLFSLLLTLSSLLPYNLFERLYLKIVQMMSSEIECRNHPDCDNQQITNYSTNNSQPCRLHGCVHGVNSTTAFMPKEEKRNWAWPKPLVDSQPEHKTSTKELHITLSGVGPTLPYKSRDVSTVLPFMNNEHYHASTSQSELLSLSMTANTSYAYHDPSYGGLLSPFGFQTMHNSDYSRMALPLAMAEEPVYVNAKQYHGILRRRQSRAKAEVENKISRSQRKPYLHESRHLHAMRRERGCGGRFLSKNKKAEASSLLDDDDGEGSNISLGSESMCNGSKCYQGSQLHLSAYI
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MAVGKEILTKIRSVQNTQKITKAMQMVSTSKMRKTQERMRLARPYAEKVRMVMSHLAQTNTDHGIPLLESHREIRRVGFILITSDKGLCGGLNANVLKKFLAQVQEYRNQGIEEEIVCFGSKGLMACQSIGLNVVASAVNLGDTPKMEMLLGPLTELFQRYEKHEIDRIHLVYSGFVNTMRQEPRMEVLLPIGENVIGDSAPKSPFSWEYRYEPTALAVLEYLVRRYLESVVYQALSDNMASEQAARMVAMKAATDNAGNAIKELRLVYNKSRQAAITTELSEIVAGAAAV
The following text describes a protein:
Function:
Involved in morphogenesis. May be involved in cell wall organization and biogenesis.
Sequence:
MLYNKEQGTSGASSSGRRTKFHFDRFVQMVLFIAANPNYCCSVASIPKSGVTPDLKRADILEQKIKSLNSALSPKLKEESRLGGPLHNPSILPAPSFSSLPISSNGKKSLAGYRPKSRKKQTILPNGQPKECATCGDTWTSQWRSGPNGNVELCSRCGIAYRKKMEKKIRSQQSSDDGTKNFIFKNK
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. Not essential for growth.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes at the septum.
Sequence:
MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQYGYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFILYLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPTAVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNKRKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIEAGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQTMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVNAAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIMIKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAAAVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MEEAPFYRDTWVEVDLDAIYNNVTHIKEFIPSNVEIFAVVKANAYGHDYVPVAKTALEAGATRLAVAFLDEALVLRRAGITEPILVLGPSPPRDVNVAAENDVALTVFQKEWVDEAIKLWDGSSVMKFHINFDSGMGRIGIRERKELKEFLKSLEGAPFLELEGVYTHFATADEVETSYFDKQYNTFLEQLSWLKEFGVDPKFVHTANSAATLRFQGITFNAVRIGIAMYGLSPSVEIRPFLPFELEPALSLHTKVAHIKQVIKGDGISYNVTYRTKTEEWIATVAIGYADGWLRRLQGFEVLINGKRVPIVGRVTMDQFMIHLPCEVPLGTKVTLIGRQGDEYISATEVAEYSGTINYEIIATISFRVPRIFIRNGKVVEIINYLNNI
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSLGTVVYNTVSRRFSTILLASAFGAYAFNYTLDGLTNFYWDTSVAAPHPQSSPPQKNANKQWKDIKQQLAQE
The following text describes a protein:
Function:
May be involved in virulence. Binds human plasminogen (PLG) and stimulates its proteolytic cleavage to enzymatically active plasmin in the presence of an urokinase-type PLG activator in vitro. Activated plasmin has proteolytic activity which may help the bacteria to spread throughout the host by degrading extracellular matrix components, facilitating tissue penetration and invasion.
Subcellular Localization:
Cell outer membrane.
Sequence:
MNSNPKKKFLKLIKIKSDIILLIPIFLFLVCCKSGDFSLLSSPINREKNGTEIVKFSIHPYKGTVIRLGEEILPFKVLEMDKNIALVEMAIPVYKDEKEIELKLSSPGFQNSSYRIRKPEELNEKLIALDKEGITHRFISRFKTGFQPKSVRFIDNTRLAIPLLEDEGMDVLDINSGQTVRLSPPEKYKKKLGFVETISIPEHNELWVSQMQANAVHVFDLKTLAYKATVDLTGKWSKILLYDPIRDLVYCSNWISEDISVIDRKTKLEIRKTDKIGLPRGLLLSKDGKELYIAQFSASNQESGGGRLGIYSMDKEKLIDTIGPPGNKRHIVSGNTENKIYVSDMCCSKIEVYDLKEKKVQKSIPVFDKPNTIALSPDGKYLYVSCRGPNHPTEGYLKKGLVLGKVYVIDTTTDTVKEFWEAGNQPTGLDVSPDNRYLVISDFLDHQIRVYRRDGF
The following text describes a protein:
Function:
Required for the transfer of T-DNA to plants. Couples energy, by means of ATP hydrolysis, to T-DNA transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MEVDPQLRILLKPILEWLDDPRTEEVAINRPGEAFVRQAGAFLKFPLPVSYDDLEDIAILAGALRKQDVGPRNPLCATELPDGERLQICLPPTVPSGTVSLTIRRPSSRVSSLKEVSSRYDAPRWNQWKERKKRHDQHDEAILRYYDNGDLEAFLHACVVGRLTMLLCGPTGSGKTTMSKTLINAIPPQERLITIEDTLELVIPHENHVRLLYSKNGAGLGAVTAEHLLQASLRMRPDRILLGEIRDDAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSAQGASLEDRTLIDMLATAVDVIVPFRAHGDIYEVGEIWLAADARRRGETIGDLLNQQ
The following text describes a protein:
Function:
Transcription factor that negatively regulates genes involved in anthocyanin biosynthesis.
Subcellular Localization:
Nucleus.
Sequence:
MGRSPCCEKAHTNRGAWTKEEDERLVAYIRAHGEGCWRSLPKAAGLLRCGKSCRLRWINYLRPDLKRGNFTADEDDLIVKLHSLLGNKWSLIAARLPGRTDNEIKNYWNTHVRRKLLGRGIDPVTHRPIAADAVTVTTVSFQPSPSAAAAAAAEAEATAAKAPRCPDLNLDLCISPPCQQQEEEEVDLKPSAAVVKREVLLGGRGHGHGHGGALCFGCSLGVQKGAPGCSCSSSNGHRCLGLRGGMLDFRGLKMK
The following text describes a protein:
Function:
Involved in cell shape control.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVVAIGVGGAGGRIVDALHEDDSTREASYLAGGSVLETDRGALAALDAVSEEDRHHFGHSGFGGDADSPRERIEALAEDDHVEMRRAVDSAITSDAAAIIVIAGVGGATGSVIAPKLTDALQRIYDRPVYAVSVLPATHEEVPPENPARAIAAFESAANAQLVFDNDAWVDDRNDVEDVTDGLNAELAMRLGALFSAGEAVTAESVGQRVVDASEVISTLDEGGLATIGFARQPLGTDGDDGSLLDRARELVGMDETTVDEVESIKAVETTLRQATNGRLTFDCPRDAARSGLLVVSGPPEWLHQTAVSDGQSWLADEIGSVQLRTGDNPMPGGDELTILVLLGGIRGAPRIKEIQAATD
The following text describes a protein:
Function:
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
Subcellular Localization:
Cytoplasm.
Sequence:
MTQHSRDTPQFYLTAPSPCPYLPGRHERKVFTHLVGDRAGDLNDLLTHGGFRRSQSIAYRPACDQCRACVSVRVIANEFRPSRNFRKVIARNADIIGEQRSAVPTSEQYSVFRAYLDARHRHGGMADMTVLDYAMMVEDSHVETRIIEYRKRGPDSGITGRGEELIAVALTDVLSDGLSMVYSFFEPSQVSRSMGTFMILDHIARARRQGLPYVYLGYWIEGSKKMDYKARFLPQQRLAPSGWLRIDAQGDAASEPQD
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MPRAIRGVLIQCEPAIKSIIVHLDSVNNDIIIEDLDEQTLVVKENMVQLLKQKLEDRLKETYRPEEPLADSD