lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).
Miscellaneous:
MISCELLANEOUS: Might carry two S-adenosyl-L-methionine binding sites with only one binding to the iron-sulfur cluster.
Subcellular Localization:
Cytoplasm.
Sequence:
MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINTIAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSAEKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLMFGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAEMYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTVNVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSLDGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL
The following text describes a protein:
Function:
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Sequence:
MSTRFAQIVMGPAGSGKSTYIRRMAEHYETIKRVVHCVNLDPAADELFYDPVIDIREAINVKEVMNKHGFGPNGALIYCMEQVVSDYEWFDTEIGEHEYDYLLIDFPGQIELFSHLNILPRLIAMLQEKGYHLCAVFLLDSQFMIDPSKFLSGGLVALSAMTMLEIPHFNILSKCDLLSPQQKDTLDLFTEMDTMSLGSSVKKGTSIDKLTTKICELIDNFNLLQFYPLNIKDEDNVVGISTEIDIILQYFDNADNDDPEFGNQDMEDEGPDPLENKD
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEFTDFSKTSFYYPSSQSVWDFGDLAAAERHSLGFMELLSSQQHQDFATVSPHSFLLQTSQPQTQTQPSAKLSSSIIQAPPSEQLVTSKVESLCSDHLLINPPATPNSSSISSASSEALNEEKPKTEDNEEEGGEDQQEKSHTKKQLKAKKNNQKRQREARVAFMTKSEVDHLEDGYRWRKYGQKAVKNSPFPRSYYRCTTASCNVKKRVERSFRDPSTVVTTYEGQHTHISPLTSRPISTGGFFGSSGAASSLGNGCFGFPIDGSTLISPQFQQLVQYHHQQQQQELMSCFGGVNEYLNSHANEYGDDNRVKKSRVLVKDNGLLQDVVPSHMLKEE
The following text describes a protein:
Function:
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
Sequence:
MKVTLFVTCLVDMFETNVGKATVEVLERLGCEIEFPEAQVCCGQPAYNSGHVEAAKEAMKHMIETFEDAEYIVTPSGSCATMFHEYPHVFKDDPKWAKRAQKVADKTYEFTQFIVDVLKVTDVGASLPGIATIHKSCHMTRMLGVKEAPGILLSNVKGLTVRDLPNVQNCCGFGGTFSVKMTPISEQMVDEKVDSVMETGADYLIGADCGCLLNIGGRIERLGKEVKVMHIAEVLNSRS
The following text describes a protein:
Function:
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSSSRYAKLVEFAAHAGDVRCVRIGRKTAGVLVTGGDDKKVNVWALGKTTASFSLTGHQSSVESVSFDNDEMVVAAGGSNGSIKVFELQTGKVTKSLSGHKSNVMCLAWHPYDSTIISGSMDTNVKLWNLRDKEAVMTFKGHNAGVTHVRYSPDGNWVASASGDGAVKIWDVRQGRLLQDLCPPTKYEITGVEFSPTEYLMATSSRDKLVRFWDLETFACIDQTTPEATPVRNICFYNDGRTIFSAVQDGCRVWNVDPTQQQDYVDVPWYRVADLAISTIRGTQRLIGCSFNSTMVGLFYIVLKNVRPFCEDPDFMAREPAASVDGNPYAAAGGSRSNLAGAAAAAQLPPESAVRRLSLNDRAADPPRAGSAGNLGDAAAAAAAAAGYGNGRGAGVAAGVGPSVGVGRSQERSSSMGSRPPQAPSSSAVAAGGDRLPPVALYGAPDRDRERDRSSNRYAGAAGASADFGGGPGDSVASDAQLGRAASGHAAGARPGMVSIGVGVGDSLMRGQLQPDDLSRMAGGGGGGLARQRSQPREPTIEVHAPAAPPASRSAGSGPGYRGAGSGPDRGVGVGVGVGVGEDRDMDQRYPWQGPGGAAAGPSGMDRLGGGGGGAGGGGYASVVPSDLEAASALSSRHGMFLSAMKKRANTLMIMRNFVQKGDWRNAIAAARRGDDTAALADLLSAMHDRRDVFTLDLVGEVMTVVETVLSLPSDRQQQTGLEVLALHIRAFGPVIRDLCGPGARGVGIDLSFEERRERAAKAKLVLQNMVPRLNSLARSSETLGVRAGELAAQLAQL
The following text describes a protein:
Function:
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (By similarity). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (By similarity). Helps to maintain integrity of nuclear structures in response to mechanical stress.
Subcellular Localization:
Nucleus lamina. Nucleus envelope. Nucleus inner membrane.
Sequence:
MDMSKKKSKRASPIESSQEEIAISTSKTATTEKPKKTKTTTKKKASQPSQEVVMETESEVEITTTTTSTSTTNNNNITTTSTSSQQSNGTLSSSSSPTIQSIPTTPISKYIPSLSQIGTPLSPNRAAQRLREKDELSLIHNRLKSALKKLESAETELEKKNQEYEELDQKHTATIKQLKQRSDQVEKQLIEEQNQNSDLTSNRNILENELKSKESVWKKEKDEILLKFQESINKLNQENSLAQSQLKSEIVSKEYEIDGLKSEINRLKDDLQYRIREGEEKSRKLLENEYNRFKGKEEEYNQLIVSKDEEIKKYKFELKEKEKSSNAMNKKENELNNLIQAHERQIEDMRDSINREWELKAAQMMEEHHARTIHLQQAVDSFNEEKERIKSQMETLNGQIEDINIKNNEYEDRIKEMNVLLSQKDNSIGELGVEIEESKKKMRKQMADLKSKDGQIALLQIEINTKDNKCNTLQTETNRLKSELYSITNQIDPEIPLDPEINSLKELVKGFEKTVDDRKRKRSKLQHEFNAAANQDQNGMTIEEQSSTSTTTTTSATGSSSSTSHLDNIDSSKLPTGPEQSELFNPDTVSFSLVDSNQEFIKLSVHGDMDNGLSISKWRLIVVKPDGSKSGFSFPDGIQPFKGIKSVTVWTGRPRPQGTPTENEFYWARTELWTSPVEGTIVKLVSPSEETTTVTLPADGIYQKPSSAGKSNCLIM
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
SSLMKDAVFGSGEFGDLGLEPRLAAHLHGAMGFQSPTVVQKSAIPLLLSGRDLLVNARTGTGKTLVYLAPIVHGLQAREPKITRTEGTFAVILVPTRELCIQVCGVAEQLVHRFHWLVPGHIMGGENRAKEKARLRKGITILIATPGRLLDHLKNTASFQYDFLQWIVFDEADRLLDMGFEKDIRSILDFLGTHQRNGSKRQHVLLSATLNDRVNKLAKISLCDPATIGLSSTPPEGAPDLDTNANIEYSISDKLQQCVLKVSSKIRLVTLLALLRLKLNSTKGSYKIVVFFSTCDAVDFHHTVMSRFSWVMDDGSSMRGRFLDCDIFKLHGNVEQRERTDTFHKFSQAERALLLCTDVAARGLDFKGLSFIVQYDPPGEPVDYVHRVGRTARLGRKGEATLFLQPCEAEYVQELRKHGVVLKDLDTRKVLDSIYTISQKRSFASVEVAEMHPAAAAMQTALESFVTSEGDLKQLAVNAFRSSVRAYAVHREGLRKIFQVRMLHLGHVAKSFALRDAPSGLSKCSAQKASKRMRAEKKRAGKKRRLHAAKME
The following text describes a protein:
Function:
Endogalactanase involved in the degradation of plant cell wall polysaccharides, and more particularly of hairy regions of pectin.
Subcellular Localization:
Secreted.
Sequence:
MLGKMILLPLFVLLCHSLASASLAYRGADISSLLIEEKAGIKYKDVNGQAQPLENILKANGVNSVRQRVWVNPSDGSYNLDYNVKLAKRVKAAGMSVYLDLHFSDTWADPSHQTTPRGWSTNDIGTLTWQVYNYTKEVCDTFASNGIDVSIVAIGNEIRNGLLWPLGKPNNYANIANILHSAAFGVKDSTLSPKPKIMIHLDNGWDWSAQKFFYDSVLSSGAKLVKSDFDLIGVSYYPFYNPSATLSALTTSLKNLRSTYGKDVLVVETDWPVSCPNPAYAFPSDLKDIPFSVAGQKTFVQRVANVVAQTPGGIGLYYWEPAWVQNAALGSSCADNLMVDWRTDQARTSLSVFGTI
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MSDRGASAPSLPDDWPAHPDPILALNRMGSFDWDLDAGLFHMDAQAHEVFDLRPEEYDGRPESLALRVPTAESRRMDTIVARAMKDGSENYGTYFRLRRRDGTLRWTHTQGYIRRDETGRPRRIIGIVRDATQEMADIAASREQAALDEARRRLTNVVQLATAALAHARTVDDVIDVLRDTHGLTRLGATSLVMGLVEAGRIRLVADGPENSFIPGTRVTRIDEPYPMSEAVRTLSPRFIESPEEFAERYPGLWKDITHLDITAAAYLPLIAQARPIGAIGLLYSDRHGFSPEDRNVLVALGSGIAQSLQRAMLYEQEMDLAEGLQQAMLPRTIPSVPGCDVAVRYRAASIGGALGRDIGGDWYDLIPLPGGRVGAVIGDVQGHDTHAAAVMGQLRIVLRAYAAEGHPPATVMARASVFLHELDTDRFATCLYAEADLGTGVVQVVRAGHIDPLLRFGDGTCRLVRVEGGLPLGLSAEFGRLAYPVATLELDPGNTLLLCTDGLVEQPGADLDEGMDVLTALITSGPQDVRDLADRLIDVVDERRGDDDVALLVLRRHGLGAPRTFGRVQQHVSPGDPEGLTEARHMIRAAVRSWGAKGQSDEIELVADELMTNALMHTEGSAVVTLRLLTGTDRRLRVEVEDSSSALPRRREAGDDGVSGRGLLLVDTLADAWGVEARGGGKVVWAEFVVAHGAG
The following text describes a protein:
Function:
RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of HO by binding to the 3'-UTR of HO mRNA. Predominantly binds to mRNAs encoding chromatin modifiers and spindle pole body components. Recognizes and binds to 5'-TGTAA[CT]A[AT]TA-3' in the 3'-UTR of target mRNAs. Multicopy suppressor of POP2 mutation. Required for high temperature growth.
Miscellaneous:
MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MINNEPFPSADSASILTTSTSNNSLMSYNHQPQLSINSVQSLLEPVTPPPLGQMNNKRNHQKAHSLDLSGFNQFISSTQSPLALMNNTSTSNSANSFSPNPNAASNSTGLSASMANPPAILPLINEFDLEMDGPRRKSSHDFTVVAPSNSGVNTSSLIMETPSSSVTPAASLRNFSNSNNAASKCGVDNSSFGLSSSTSSSMVEISALPLRDLDYIKLATDQFGCRFLQKKLETPSESNMVRDLMYEQIKPFFLDLILDPFGNYLVQKLCDYLTAEQKTLLIQTIYPNVFQISINQYGTRSLQKIIDTVDNEVQIDLIIKGFSQEFTSIEQVVTLINDLNGNHVIQKCIFKFSPSKFGFIIDAIVEQNNIITISTHKHGCCVLQKLLSVCTLQQIFKISVKIVQFLPGLINDQFGNYIIQFLLDIKELDFYLLAELFNRLSNELCQLSCLKFSSNVVEKFIKKLFRIITGFIVNNNGGASQRTAVASDDVINASMNILLTTIDIFTVNLNVLIRDNFGNYALQTLLDVKNYSPLLAYNKNSNAIGQNSSSTLNYGNFCNDFSLKIGNLIVLTKELLPSIKTTSYAKKIKLKVKAYAEATGIPFTDISPQVTAMSHNNLQTINNENKNPHNKNSHNHNHNHNHNHAHNNNNNNNQKSHTRHFSLPANAYHRRSNSSVTNNFSNQYAQDQKIHSPQQIMNFNQNAYPSMGAPSFNSQTNPPLVSHNSLQNFDNRQFANLMAHPNSAAPIHSFSSSNITNVNPNVSRGFKQPGFMMNETDKINANHFSPYSNANSQNFNESFVPRMQYQTEGANWDSSLSMKSQHIGQGPYNQVNMSRNASISNMPAMNTARTSDELQFTLP
The following text describes a protein:
Function:
Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.
Subcellular Localization:
Spore polar tube.
Sequence:
MLLLLAITAVVSATMVHPSAVVPQPAAPLHVVPPQQQMGMVNGCTSKKLEGAEIMRRNMIECQKRSSEATKAMIERANEKAVESFNKEVSKGPSQKDGGQCIEKAVQGTDRCILAGIIDKAVNKRKYRISDVENSTSLYRGDKLIALIVNVDYGLQPITKPKKKKSKIMANLPQPKREMYFNQIGQLVGARGTFPQENKEDCKPCEGPKKTVETTSEKCNLGCELKGTSALISKAIQKKEVKDTKEGEKSASQDSDGEGTAEDAEVQQPSADGEGLE
The following text describes a protein:
Function:
Positively regulates a late step in synaptic vesicle exocytosis.
Sequence:
MESAATGFVFSLSSDQLSGIVKGFDRLTGEPIEPEMEDPEVVAARQEQEKRRKDKHRRMEADRERMRQQIRNKYNLKKKDEAREQEIAGRIAGNRKTPEQVALETLHAEEDESLMTAINDTFEKAKNTVASACTTVKNVVSLWKT
The following text describes a protein:
Function:
ssDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, in a RecA-independent process, since DdrA is essential for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation in an environment lacking nutrients. In vitro, binds to the 3'-ends of single-stranded DNA, protecting them from nuclease degradation. Thus, DdrA is part of a DNA end-protection system that helps to preserve genome integrity following irradiation or desiccation. Does not display DNA strand annealing activity, unlike eukaryotic Rad52 protein homologs.
Sequence:
MKLSDVQKRLQAPFPAHTVSWKPAAFNAERTRALLLAHVDARAVQDRLDAVCPDDWSFEMEVVSGAEVPTVKGRLTVLGVTREDIGEAPEGSMAAYKAAASDAMKRCAVQFGIGRYLYDLPKQWADWDDARRGPKHLPELPEWARPDHERTPGGAHLVQAMEQLRYELPEDLDLQREVYKHLKAALGSIHPVPTGPVPTNPVQGGRAA
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MGGDLNLKKSWHPSLLRNQERVWAEEKRALEERKRIDQLKRERDEERQIQELQRLQESAGGTRQLQRVDWMYQEPSSASGHYAEEMEGYLLGKRRIDGILLKNDESKKLEKGAATGPGAAAGLPPVVHNTRDTMAKVMADPLLEIRKREQAAYEAMVKESVRRREREQGRERHQERERERGHRHRRDSGNDSHRSHRHRRRSRSRSRSPRVEKDDRRHRDREHDRRSHRDRDGERENRVERVYHSSRRDHDRDERYDRAARRSASPRPDRRRDDRRDRDQDQDYRRDRNSRSSRRDARSSRDRDTDAFGRDRNRDRGSHSRNGNADANADQHAQELEEQRKRRLAEMQANAQDMEATRRQRVAEVTALEEKQREEDDKRRSDRGQFMSGLHRQLQEDSLDERIRRSRGALTKDED
The following text describes a protein:
Function:
Non-catalytic component of the proteasome.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNSHEEVQRTLNPTCTGTSVIALQYKTGVVVLTDRVVSYGKMARYKNVSRQYKVNENVLIAFGGDHADFHGFKMSSNAKYFSGNASIKILGRKHSTDTSLAFSTEGENFLAHAIVKIRIFRRCKMNPVWNTLVVAGVEEEEKNNKETSTPFIGVITQKGCAYQVKHIATGLGAYLLNQAVEDEWRKKGEDLSREDAEAVLRKSLELTLYHDCVADNEFEIGRVDATEGVVLGKEEKIIGDWSIAETNCQYE
The following text describes a protein:
Function:
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MTTVVKKSKDRGEAIHNTSMLTSQMTHPGLGDGLLEHVRKKLAQVKLDHPSKSVSLATQTGPTETEVTVGRKTQVIKQVTSDKEITTIEDTVTESITVKSRKPLKAVYEEHLTKEAYLEGLKKGTLLKGTLRILDSFHSAFVTVEGYADDFYIDGMIARNRALDNDTVIIETLKDRAPASESVTVQGSSSSEDDLTADPALPTSVASSNPNAKVVAIAERWPRDSVVGILHPPGWSPNTGSPRNSKSNYCIFQPQSKRMPFHLIHKNDLGELSGSNWREQITQNEGVIFSVKRKTWSATSRYPLAKVDKRIGHLSNIEASTQAILLERMVNSREFPDEVLDCLPSDNWCITDEERAKRRSFLDQIVLTIDPETARDLDDAVSCIDNGDGTYRISVHIADVSHFVKPETALDNEARSRATTVYLVQRAIPMLPTLLCERLCSLNPSVERLAFSVEWLVDRNGRELGPRWFGKSLIKTCCRLTYTEAQNILEGKSWEEGVGKPISDGFKATDVEVSIRNLNIIAKALRKARFDNGAVSVNTSELKFRLDEQGLPQKCEVYEHKDANRLIEEFMLFANRSVAEKISNHFPHVALLRRHAPPKEKQLGEFIRFLAHLGFDFDGSTSARFNDSLQRLREKFPSDITELIENMAARSLQRAEYFCTGSTDSVSEWLHYALAFSHYTHFTSPIRRYPDIIVHRLLECAVQDCDSSLKTKQCNEIATHCNTKKENARLAQEDSNFVFLSVYLNKYSEEHKVPAMPVRVFVTRILDHSIDVHIPVFALTRRISFLDEPSLESFEVDDSEEHVQLTFKNGTSTKLSMFNDFTAYLAADFTKTFCNIKCSLHQPVTELPDNQKSVTDTTE
The following text describes a protein:
Function:
Plays a role in vesicular protein sorting.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MASPPPVEDQARLLEDALAVVRQQTMLMRRCLETPGKLMDALKCSSTLVSELRTSSLGPKQYYELYMAVFDALRHLAVYLRENHPVNHLADLYELVQYAGNIIPRLYLMCTVGTVYMAIEDAPVKEIMKDMMEMSRGVQHPIRGLFLRYYLAGQARDHLPEGDGEGPEGNLQDSISFILTNFVEMNKLWVRLQHQGHSREREQRTKERQELQLLVGSNLVRLSQLVDLENYKKILNPLLEQIVQCRDVLAQEYLLEVVTQVFPDEFHLHTLDQFLSAVARLNPHVNVKAIVVGLMDRLSMYAQRESESESPEQRKKTEEESIAKLLEQMRIAKEKKETEPEPAPAPAQQNGDASEAQPDGEEAQTEASSVTAVSVADHEAAETEGVVEKKRGIPSNVKLFEIFHEQVQTLVKMQRLPIQDTIGLLVSLANLALNIYPERLDYIDQVLTFANQKVGEYQNSADLHSQATQSQILSLLLAPIKTYVSLFTALALPNYIPLLHSQPYPTRRAVAGEVARSLMRNQTYITSVENLESSLEILKVLIREGIQQATGYPGGPIQRRAQETDETIEEQGWLARIVHLIRGEDNDTQFKLLQTARKAFADGNERVKYTTPAIITASLKLARQYKKREHFDDNWQSQSSALYKFMHNTLSTLYTRVNGSADLSLRLFIACGQVADQNNFEEVAYEYFAQAFTIYEEAISDSRAQFQAVCVIASALHTTRNFGKENYDTLITKCALHGSKLLKKPDQCRAVYLASHLWWATEIRALGEEDPKTLYRDGKRVLECLQRALRVADACMDAAVSVELFVEILNRYVYYFDQENDAVTTKYLNGLIELIHSNLQSNENASSLENPRKHFQRTLDYISSREYEGVVTAAK
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
TVQQEQLEWEAVNRILQHHGFKPIHFADPMENKNLSDLVLLEKRSASEVRLALKTLLKDTERRQALIQELIQTNNQLKIQIKGFQGLNYIMTQRRPIFKSVSICPQHHTIETTYVGRTAKPHSQLDQQLDLCLRKDMFLYSISIRACTLCFVVKHFLRIGCQCSIYNISAFSSVLRQSLRCAFSVSYRILDVIDVYEAQIQELRTELRTWRGDADVTDQNGPAGSRTKEERNRTIDATLNYKALLKSYQEQLKETKAQKEELREKIQTLKQELESRPTAKELKSCKQQLKRMDRIIQQTNVKNLRSAQLCSAEENGKDKDSTDVEHIDSLQASLCRWYLKGACKELEVQDLNDLIPAAKLRAKQAASVPKLTKVLDALKAVMSNPRAPVLLHRQRPSRLLPPDSPEEVGLELIVPTIDMWANQLMSLKDLHCALRKLLLRVAPWQSAGTQGASETVRVEELLLMADVMLEETAKSEKEMRSPTRNTLHAMVTHFQQLFDVNSIAGVYPRMNEVYSRLGEMTNAMRNLREILGLDEGAPPSALVNKVGWLCASLSQDTSQQLAGLLGASDIDSIITKLEEHEEFFPEFHSLVLELLHILDVRHLDEIVPAVRSLQMTNE
The following text describes a protein:
Function:
Essential protein. Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that positively regulates the transcription of a subset of genes.
Subcellular Localization:
Nucleus.
Sequence:
MASSLSSKAKTFKSPTKTPTKMYRKSYLSPSSTSLTPPQTPETLTPLRRSSRHVSRKINLGNDPIDLPGKESVEEINLIRKPRKRTNDIVVAEKSKKKKIDPEVSFSPVSPIRSETKKTKKKKRVYYNKVEFDETEFEIGDDVYVKRTEDANPDEEEEEDPEIEDCQICFKSHTNTIMIECDDCLGGFHLNCLKPPLKEVPEGDWICQFCEVKKSGQTLVVVPKPPEGKKLARTMKEKLLSSDLWAARIEKLWKEVDDGVYWIRARWYMIPEETVLGRQRHNLKRELYLTNDFADIEMECVLRHCFVKCPKEFSKASNDGDDVFLCEYEYDVHWGSFKRVAELADGDEDSDQEWNGRKEEEIDYSDEEIEFDDEESVRGVSKSKRGGANSRKGRFFGLEKVGMKRIPEHVRCHKQSELEKAKATLLLATRPKSLPCRSKEMEEITAFIKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAEVEAGSVSPYCFVEINGLKLASPENIYSVIYEGLSGHRVGWKKALQSLNERFAEGKKIGKENEKPCILLIDELDVLVTRNQSVLYNILDWPTKPNSKLVVLGIANTMDLPEKLLPRISSRMGIQRLCFGPYNHRQLQEIISTRLEGINAFEKTAIEFASRKVAAISGDARRALEICRRAAEVADYRLKKSNISAKSQLVIMADVEVAIQEMFQAPHIQVMKSVSKLSRIFLTAMVHELYKTGMAETSFDRVATTVSSICLTNGEAFPGWDILLKIGCDLGECRIVLCEPGEKHRLQKLQLNFPSDDVAFALKDNKDLPWLANYL
The following text describes a protein:
Function:
Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.
Sequence:
MSEPPQVFRATYSNTDVYECMMNESSIMRRCKDDWVNATQILKCCNFPKAKRTKILEKGVQQGLHEKVQGGFGRFQGTWIPLEDARKLAKTYGVTEELAPVLFLDFSDPNLIIPRKEKPASKEPAAAKRKYMKKAKQAGDPPRRYKTGKKAALQAAEEAAAAAAAAAAASTGTGPGNTLPITTSASRIISQLSATTPANVAIQGNSQIQTGQIHDVMSSQDTFNSISRQNSYIPPTAQQLPHMYNMSQSTPASSQQPIDNGNTLIGTSNGGFGQPEFQPVSNNNMPAYPNDIQNFQMFQRMQQQQQQQQQQQMPTQQRFFQNGSAPNPIPQQILHQGKVSSSQSSNDSNWSFSNTQKDSDTSINSTAEEPRKMQLQEPSPQADNGYAAQLLRFFSEDNVDIPYFIIYPPADFNINEPIDDEGHTPLHWAASIGNFEMIHLLLSKGANPLVVNNFGLNPLSKLISFNNCFELKNFPTVLDDLELCLINTDINGRTPLHYLCQFAKSKTKNDSLVYYLKVILNKLTILSNQSQVRQINLMKNVLDHQDVHGDTCLHIAVRSGNIDIVKILLQYGAMDDLENINRETARQLITQCNLIPNYTQVDAAQVAYQNQMQLGMGDYSNYNVNNNAMNQNHNESSHNVPIVPGLATPIQSTFTKVETPDTQRTTVQEDDMDDDNESVVARVDKKHLEALTDNKENIFTEKHFDNISTPINKKHNPINSHHPLAVISEVEITTSNSVSETPMPLPEGKNQRKQQQETPLPLPLSLPKQQQDEREVSGDESTPHFYHPHPPKLNDEGKIEDTEDNVEPKLPMSDLSSMISGMINSLSHTYTSDSAKLDLEIFKLKESINLKQQENQESLTRVQKLLINSGIQESQIESIEQGQELIIETIEVCERTIKEKEQELLKVLQHNQSIELAKLVEQHESRYLEEDKKNHYENSHNRDDDLIDQSRIDDAIELSKLQLERNRLVNEIVLHTKSFGIDEKMYKYRKLLSLSCGVKVEEIDSLIDGIAESLTEGMT
The following text describes a protein:
Function:
In vitro, can cleave S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine (AdoH).
Sequence:
MQLQKLVNMFGGDLTRRYGQKVHKLTLHGGFSCPNRDGTIGRGGCTFCNVASFADEAQQHRSIAEQLAHQANLVNRAKRYLAYFQAYTSTFAEVQVLRSMYQQAVSQANIVGLCVGTRPDCVPDAVLDLLCEYKDQGYEVWLELGLQTAHDKTLHRINRGHDFACYQRTTQLARQRGLKVCSHLIVGLPGEGQAECLQTLERVVETGVDGIKLHPLHIVKGSIMAKAWEAGRLNGIELEDYTLTAGEMIRHTPPEVIYHRISASARRPTLLAPLWCENRWTGMVELDRYLNEHGVQGSALGRPWLPPTE
The following text describes a protein:
Function:
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
Sequence:
MKVIFNADDFGLTQGVNQGIVKAHLDGVVKSTTLMVGMPAEQHAVQLAKQLPDLKIGLHLRFTAGRPLTGERNLTDEHGVFTAYRDFWQRRDYQPEAIYHEAIAQVEHFLKLGLTLSHLDSHHHAHTHPQLAPIIYEVAKKYHVPLRDIGMAGEEAFGCRYHFTDFFYDQRLGIDPLMKHLLELKERFDLVEVMCHPAFVDPLLEKCSGYAKQREEELHILTSAQLIQLLVAHDIEITDYSALISAPLHSCV
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAPKNDDVDELFEIRNSFYIGSFQQCINEAQKLKPSSPDLALARDVYMYRAYAAAGRYGVVLDELSSASSLELNAVRLFADYLANPDRRDKVVSDLERKMSSSVDANNDTFLLMAGSIYYHEQNYDSALRCLRQSESLECIAMSVQCYLSLDKVDLAKKEVKKMQDKDDDATLTQLAQAWFNLAVGGEKLQDAFYIFQELADKNSSTSLLLNGQASAYMQQNKMDDAEDILQEAINKDSNCPETLINMIVISQHMGKAPEVTNRYLTQLKDSHARHPFVKDYLEKEAEFDRLATQYVSS
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MESKGARKDAVATQVRVNGFDQNVTAKELVKYLEDTVGLIRRYRLKTSWTPPDSYPDFEVTRFDTIQIADEYKKVEPHAFVHFATPEAATSAYELSLHDGLFFSNKLLKVSLGPESPFQKNQRRRTTTPFKLPDVCLEIGNLITLEEFLVGWRGPSSGVDFFVDPVDSMCRFCFTRKTAFSFKEQSTYAVINCEFKMEFLVGEINEIRQHREMSSIVILLQLASPPCLSLIRTTDFTASGAVGRCNTYRVSIPPLHGLKLKKAMDYLREQEVRELSPRQSLRIQDESNFVRPMLDTFSSIHQKGIGFDVMFLLKAAIHKNVFSQHQLSESFFGLLKSQPKAVNLAALKHICSYKHPVFDACKRLEPLQECQLKNPKLLKNQKELNNIVEIRRLMITPIKGIVFHLKWSYLTEFLRVTFMDEGLQMINANVLKDWSAWFFAEDKKIDVKKIRVWMGKFNCRNTAKLAFRMGQCLSSTYATVEVPQEEVYHDLPDIDRNGYCFSDGIGTVTPDLAREVAEKLKLELDVPSAYQIHYARYKGMSNHTMLEIRSWTRFKPGFLNRQIVTLLSALKVPDEVFWDMQEKMVFKLNRMLIDSDVAFDVLTSSCTEQGNIAAIMLSAPQLQGLREEARIFLPSGRWLMGCLDELGVLEQGQCFIQVSTPALENCFIKHGCRFSETKKNRKVIKGCVVVAKSSCLHPGDIRILEAVDAPVLHHLYDCLVFPQNGERPHPNGASGSDFDGELYFVTWEENLIPPSKRSWAFMQYGPAAEKKLPRYFTLKDMIDFFVKHVLNENLEAICNAHMVHADHSEHGALDENCILLAKLAAAAVDFPKTGSLYKVNNEEELVTSHVWSMPNYASRKQGELKDRLKHCYVALRKEFREIFETLDLDSKSLSNEKRNLLSPTKKSVDLREHDDGGTSALMLSFAWIAAWIAADVLARIKIRNQEGGDLDSAKPINSLSKYIADRI
The following text describes a protein:
Function:
May act at junctions between the membrane and the cytoskeleton.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Sequence:
MTARFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDIVFKHLDLTERDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNLRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPYNTAALLASFAIQSELGDYDHSENLPGYLSDYSFIPGQPQDFEKEVAKLHQQHIGLSPAEAEFNYLNTARTLELYGVELHYARDQSNNEIMIGVMSGGILINKNRIRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSLSDERLETQSLPSRSPPGTPNHRNSAFTQEGTRLRPSSVGHLVDHIVHTSPSEVFVNHRSPSSTQANSIILESSPSQENSEDGQPPALPPKQSKKNSWNQINFSYSQQDLDNHINETFDVPTSPEKSTPNGGIPHDNLVVIKMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTSADLCVPRLNEGDQVVLINGRDIAEHTHDQVVMFIKASCERHSGELVLLVRPNAVYDVVEEKFENEPDFQYIPEKSPLDGVHQNDNALRESMIQLAEGLDTGTILTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKENDDYINANYINMEIPSSSIINQYIACQGPLPNTCMDFWQMTWEQGSSVVVMLTTQVERGRVKCHQYWPELTESSSYGNFQVTCHSEEGNSAYVFRNITLYNLEKNESRQLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPIIVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYKFVCEAILKVYEEGFIKPVKT
The following text describes a protein:
Function:
Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity.
Miscellaneous:
MISCELLANEOUS: A cell surface antigen recognized in lymophocytes by multiple mAbs; MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cell surface. Membrane; Single-pass type II membrane protein.
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs.
Subcellular Localization:
Nucleus.
Sequence:
MEETRKLSPKPCKSKEPVKTEWGAQSVVFTYFQGDINSVVDEHFSRALSNARNPQDLSTKHKSEVVVPKHDSMSPHQWNFSSHCSKPYPSSSSTSMSNSALDFPAVAMAGQYQPAALRTHPAQPADLWPFPSLGTPSLTSPVYHHAVPDLHVVDEPISDRKYGSLLGLLQQERCLMSMQECAVKQHSSSTCMTGPARLQNISQSSVPGGERKASSYQGSENPSASHATAEMHAAILQLERGKTFC
The following text describes a protein:
Function:
RNA-binding protein. Inactive exonuclease.
Domain:
The 3'-5' exonuclease domain lacks the conserved Asp-Glu-Asp-Asp (DEDD) residues that coordinates divalent ions essential for exonuclease activity.
Sequence:
MNKSDGNESFALDSLPENIRYPFGKRELEILEKQLDRIVLIYQVDTTYHSALKDIKDQKIISLLVEPSFYGRHHPTSILVVATCNGTYIFDIKALGLIFLELAKILEADQPRKVIHYSHRIADHLLHRQRISLGGIFDTFVAVCLSSNTRIPYTLPEAISLVFGLPMEKVTGGCESQRNFTARPLTHSQMRYLAKLVQLQHIMHDHLNYSHIFCAEVYRISLEFSHSYYGLRSCDVAINMAPASSFGFQLLDSFCKKADKELEQI
The following text describes a protein:
Function:
Could be involved in splicing and/or processing of chloroplast RNAs.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MSSAYCSSAVAVSAAATASSAATFNPLLSSHSNSQLFYRFTPKSFKLVANCPNPLILHSNIRRHRFFCAAETEASSADDEIQASVEEEEEVEEEGDEGEEEVEEEKQTTQASGEEGRLYVGNLPYTITSSELSQIFGEAGTVVDVQIVYDKVTDRSRGFGFVTMGSIEEAKEAMQMFNSSQIGGRTVKVNFPEVPRGGENEVMRTKIRDNNRSYVDSPHKVYAGNLGWNLTSQGLKDAFGDQPGVLGAKVIYERNTGRSRGFGFISFESAENVQSALATMNGVEVEGRALRLNLASEREKPTVSPPSVEEGETEEASLESNEVLSNVSA