lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm.
Sequence:
MSTKDFNISRDEFRNITRCLDNEEFRNLFMEYCTELRDNRKQYEDELSMLEAQRGYDVKFLKPSPGYVIKTIVDGKGKGFINVCQSELVQKPTSTTGLNEDGTKGLKWSVPYAQTQPRKDYDNKRVECTVYDVMFHPDALHLASKNEGFRKLLNDTSLDAVEQSFKVRLDRANLRFPKLQYKGTPSSSVVREKLPHCDSLPKDELFDKLLPPLPNVPAPGKTGSERTTKTKNKENINRTAAVAAAAASPGNPFYTTPEYKIVQCRDVEYGEMTNELDAKIDVTIPRELKVVITLPLLKSTAECALDVTKTTLHLVSEKPARYKLELKLPYEVKESEGKATFNVEARSLTVTLPVLRKRNITLQDINSANVSASPAKEAGKLIEEIGTIIPPAGGDQQLARAASAPSAPEVPKKTIFPKFSVNKMENLLAFTLNVRNVDPSTIQLDNRTDSVHCRFSNVGNGYFPCFYVFFVRFPNALVTDVQHEEWDNNLIIQITLNTASVSSYQAGPDEHETVEYSIMEDIADKINKFGKEIEDDSLCIAVVRQATKASAKVKADALMSIEITKREEHGEPECDEKDGSEAEKARTLQKAKRNSRKKKKERSLSDSFCDHLKVIVENEASTEVAGEGATIQSSAKPIDSPEAKARKARSISECCPPKESDGGEEASTMPTLTRKYKSILKRSSYDRSISECSSVDDLGTSVEMARSIGEECRKTVRFNNSIRKQLFRSNSCILTMKKKALKRREVKRRADARRMSEGESTDNDEKDAHHHDDEHCSSSDQHDEKDAIEDDSGVSFDSESGDKEIAAAMKAEAIGGGGRGKAASKRKNSNKQGGAKSNGGKKQGTDAKNIQFKSDMIFDIEI
The following text describes a protein:
Function:
Transcription termination factor essential for chloroplast development. Required for maturation of 16S rRNA, 18S rRNA and 23S rRNA in the chloroplast. Binds to a specific region within the tRNA(Ile)(GAU) gene at a position adjacent to and downstream of the 16S rRNA gene. Required for the maturation of tRNA(Ile)(GAU). Binds to double-stranded DNA.
Subcellular Localization:
Plastid, chloroplast. Mitochondrion.
Sequence:
MEVTNTSSIMWFFRDKGFDDPSIDKMLRKCKQLEKAQSDVASENWDYLSNIVGIQERKLPYIVSRCPKILTLRLDERLIPMVECLSSLGRNPREVASAITKFPPILSHSVEEKLCPLLAFFQALGVPETQLGKMILFNPRLISYSIDTKLTVIVSFLASLGLDQDGMIGKVLVKNPFLMGYSVDKRLRPTTEFLKSSVGLSEDGIKSVVMNFPQLLCRDVNKILKPNYDYLKECGFGDSQIATMVTGYPQILIKSVKNSLQPRIRFLVQVMGRGMDEVASYPEFFHHGLKKKVESRFKLVKKNNIDCSLREMLDCNTKKFHEKFGFSEVTASF
The following text describes a protein:
Function:
Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility.
Subcellular Localization:
Nucleus membrane. Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=Localization varies during spermatozoa development. The protein is distributed in the nuclear membrane of the spermatogonia, in the nucleus of round spermatids, in the nucleus and cytoplasm of early elongating spermatids, in the cytoplasm of late elongating spermatids, and in the flagella of epididymal spermatozoa.
Sequence:
MENSVSEASLYLQDQLDKLRTIIESMLGSSSTLLSMSITPHKSTACLVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSGLAASRPSKKAKLQGQDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEVLYQGIERLDKEKANREHLEMEIDEKADKSALASKVSRIQFDATTEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDSKLDRLELDPLKQMLEDRWKSLRQQLKERPPLYQADEAAAMRRQLLAHFHCLSCDRPLETTVTGQVISVTPIISSMPGHRSVRPYTVFELEQIRQQSRNLKLGSSFPRVDMSQMERSVGRLHSMHSRMLMDMEKVQVHFGGSVKASSQMIRELLHTQCLSHPCYKRGADTADYSYSTVSRRCGGSHTLTYPYRRNRPQHLSPLEEIQIAMKHDEVDILGLDGHIYKGRMDTRLPGILGKDAPGVTKHNKAKLQQLQQLQQLQQLQQLQQLQQAQHARPHAHRQPSLGNMISPPSRPQSAQMIADSKAVPSGQKKDRPVSSEGRLLQSNVSHSSIPTDIASLQGSQQGLNMHIDVPPGEGLEEPTRGPRSTAAH
The following text describes a protein:
Function:
3'-5' exonuclease.
Sequence:
MNNRIYVAIDVETTGLQSGLDEIIEVAAVTFRGHEILDRFEQLVRPRQAVPLKITRLTGIDPAALAQAPRFNEIGADLARFIGNRPIVGHSIGFDLTMLRAQGMQFNQPVYDTFELATLLLPQVSSYKLSALAAHLGIPHPDAHRALNDAEVTARLFAMLSERMLQLDLATLSEMVRLMGKIGTPLRDLFEEALRQKARNAFRDPILAQQSTGTISAEPTLFSSAPDTGSPELPPLRPTGDTRPLDLDQIADLFSPEGVFGRAFPGYEPRPPQIEMARAVATAFNHSEPLIVEAGTGTGKSMAYLVPATLYAAQRGERVVISTNTINLQDQLYNKDIPDLQRIFATAGLPTFRAALLKGRSNYLCLKRYHELRRLENLTTEEVRALLKIQLWLPTTTSGDRTELPLVDREQSAWNRVNVSVETCTGARCPHFRECYFFRARRAAESAHLVVVNHALLIADLAAASQVLPPYDHLVIDEAHNLEDVATDQLSFNLDQASLLKFLDDLFQTGGAQVVSGLLSELPAVLSEIGGGGAAGERITAAIERMRPSLIRARTAVYECFNLLTRFVQLDPESGGQYDTRLRLTKGVRQRPEWQEIELAWQNLNDILALIGNELAGIEVQLRELEEAAGGLDDLLLRTEVLRRFATDARVRSGHVIFGDDDSICWLTYDRQRDVLTLTAAPLSVAEILQSQLFAQKQTSILASATLSIAGTFDFVKSRIGLEDCQELMLDSPFDYAQQALVYIPNDIPEPNQRGYQPMIEQAIIDLAIASGGRMLALFTASNALRQTYTAIQEVLEDHGIGVMAQGIDGSRKALVDRLKEFPRSVLLGTNSFWEGVDVVGDALSVLVITKLPFAVPTDPIVAARSELFTDPFNEYSVPQSILRFKQGFGRLIRSREDRGIVVVLDRRLLTKKYGQQFLDSLPPTRVRTGTLASLPGLVARFLQKVNGSSG
The following text describes a protein:
Function:
Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response (By similarity). Binds adenine, adenosine, AMP, ADP and ATP, with the highest affinity to ATP and ADP. Inhibits agonist-induced platelet aggregation and hemostasis.
Miscellaneous:
MISCELLANEOUS: The amount of D7L1 in the salivary glands of 5-day-old Culex quinquefasciatus is approximately 31 ng. During the blood meal, mosquito injects approximately 7 ng of D7L1 into the host.
Subcellular Localization:
Secreted.
Sequence:
MKALIFLGAIIAGVLSDEWSPMDPEEVAFEEAKCMEDHFGNDFGLAEKWMKWNLAESDGKTACYVKCLVEALGMYDKQAFQPNNIKRQYEAYKSDNGVDQAKSDAISNELGKIDAKDGKCESIAKGFIQVNNANKGVLEKIYLLDSSVRDAIYKKNPQIKPKGISIFRFCGKQFYQDGEAAYCNVRKHGFSDDPKFIKHSNCTTRGMRWMKKNGEMDESAILRGLHAVNENGKDDVVKKSLQNCKAKDESKARDYYKCIYDGLGEQLFMKVLDYIEVRSENYSYRLREATSKYDANAMRSKVKALDSEAKC
The following text describes a protein:
Function:
Involved in the biosynthesis of kanosamine (3-amino-3-deoxy-D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate.
Miscellaneous:
MISCELLANEOUS: The production of neotrehalosadiamine is dormant in the wild-type strain. A mutation in the beta subunit of RNA polymerase activates the production of the neotrehalosadiamine.
Sequence:
MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIYELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEHNFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQDEINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLEKYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTLKKLIGS
The following text describes a protein:
Function:
Has phosphatase activity toward Ins(1,4,5)P3. Controls Ins(1,4,5)P3/Ca(2+) levels that is crucial for maintaining pollen dormancy and regulating early germination of pollen.
Sequence:
MDIINNNHRDENDDDEEEALSAMSSVPPPRKIHSYSHQLRATGQKGHHRQRQHSLDDIPKITEIVSGCGISGDSSDDEFYPYATTTNSSSFPFTGGDTGDSDDYLHQPEIGEDFQPLPEFVGSGGGVGMFKVPTRSPLHSARPPCLELRPHPLKETQVGRFLRNIACTETQLWAGQESGVRFWNFDDAFEPGCGLSGRVQRGDEDAAPFQESASTSPTTCLMVDNGNRLVWSGHKDGKIRSWKMDYVLDDGDDSPFKEGLAWQAHKGPVNSVIMSSYGDLWSCSEGGVIKIWTWESMEKSLSLRLEEKHMAALLVERSGIDLRAQVTVNGTCNISSSEVKCLLADNVRSKVWAAQLQTFSLWDGRTKELLKVFNSEGQTENRVDMPLGQDQPAAEDEMKAKIASTSKKEKPHGFLQRSRNAIMGAADAVRRVATRGGGAYEDAKRTEAMVLAGDGMIWTGCTNGLLIQWDGNGNRLQDFRHHQCAVLCFCTFGERIYIGYVSGHIQIIDLEGNLIAGWVAHNNAVIKMAAADGYIFSLATHGGIRGWPVISPGPLDGIIRSELAEKERTYAQTDSVRILTGSWNVGQGKASHDALMSWLGSVASDVGILVVGLQEVEMGAGFLAMSAAKESVGGNEGSTIGQYWIDTIGKTLDEKAVFERMGSRQLAGLLISLWVRKNLRTHVGDIDVAAVPCGFGRAIGNKGGVGLRIRVFDRIMCFINCHLAAHLEAVNRRNADFDHIYKTMSFTRSSNAHNAPAAGVSTGSHTTKSANNANVNTEETKQDLAEADMVVFFGDFNYRLFGISYDEARDFVSQRSFDWLREKDQLRAEMKAGRVFQGMREAIITFPPTYKFERHRPGLGGYDSGEKKRIPAWCDRVIFRDTRTSPESECSLDCPVVASIMLYDACMDVTESDHKPVRCKFHVKIEHVDRSVRRQEFGRIIKTNEKVRALLNDLRYVPETIVSSNSIVLQNQDTFVLRITNKCVKENAVFRILCEGQSTVREDEDTLELHPLGSFGFPRWLEVMPAAGTIKPDSSVEVSVHHEEFHTLEEFVDGIPQNWWCEDTRDKEAILVVNVQGGCSTETVCHRVHVRHCFSAKNLRIDSNPSNSKSQSLKKNEGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSCSKSQKKSDGDTNSKSQKKGDGDSSSKSHKKNDGDSSSKSHKKNDGDSSSKSHKKSDGDSSSKSHKKSEGDSSSKSHKKNDGDSSSSYKSQSGKKNSNSSTVEESRNNHNKR
The following text describes a protein:
Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis. Also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26. Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
METRYNLKSPAVKRLMKEAAELKDPTDHYHAQPLEDNLFEWHFTVRGPPDSDFDGGVYHGRIVLPPEYPMKPPSIILLTANGRFEVGKKICLSISGHHPETWQPSWSIRTALLAIIGFMPTKGEGAIGSLDYTPEERRALAKKSQDFCCEGCGSAMKDVLLPLKSGSDLSQADQEAKELARQISFKAEVNSSGKTISESDLNHSFSLTDLQDDIPTTFQGATASTSYGVQNSSAASFHQPTQPVAKNTSMSPRQRRAQQQSQRRSSTSSDGIQGRQPRDTHTDHGGSAVLIVILTLALAALIFRRIYLANEYIFDFEL
The following text describes a protein:
Function:
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Sequence:
MNTSHKTLKTIAILGQPNVGKSSLFNRLARERIAITSDFAGTTRDINKRKIALNGHEVELLDTGGMAKDALLSKEIKALNLKAAQMSDLILYVVDGKSIPSDEDLKLFREVFKINPNCFLVINKIDNDKEKERAYAFSSFGMPKSFNISVSHNRGISALIDAVLSALDLNQIIEQDLDADILESLETPNNALEEEIIQVGIIGRVNVGKSSLLNALTKKERSLVSSVAGTTIDPIDETILIGDQKICFVDTAGIRHRGKILGIEKYALERTQKALEKSHIALLVLDVSAPFVELDEKISSLADKHSLGIILVLNKWDIRYAPYEEIIATLKRKFRFLEYAPVITTSCLKARHIDEIKHKIIEVYECFSKRIPTSLLNSVINQATQKHPLPSDGGKLVKVYYATQFATKPPQISLIMNRPKALHFSYKRYLINTLRKEFNFLGTPLILNAKDKKSAQQN
The following text describes a protein:
Function:
Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MLPDGLSAEDEQRCRQLLARTTARLRSRPAAAAVLVPLCLVRGVPALLYTLRSSRLVGRHKGEVSFPGGKCDPDDQDVIHTALRETQEELGLEVPKEHVWGVLQPVYDREKATIVPVLANVGPLDLQSLRPNLEEVDEVFEMSLAHLLQTQNQGYTHFCQGGHFSYTLPVFLHGPHRVWGLTAVITELTLKLLAPGFYQPSLAVPELPRG
The following text describes a protein:
Function:
Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MAPKKHSAFMVFVTEWRNHNVEGRRMTLPQAVSHCGTIWEKMTAQQRGPYQSGAKDADVADRAKRERLNCHGQGIAQVDQVQKEAAESLMHMKRSTERLVINAKKSHDLENAKFVFATFNYFTKALTTDVYVPAEFAACEYSLKEGIRSIYSSMIDPGQIIFGQGSDALHHSSTTHDLPLPPNALGEKNMAKLYRNIIDYLTKCQGGDKPLIVFTPAENIAMVKSCFRYLECEDDSKDGGRTIQVFDIEYLLFILKKEVMDVADLNDEKINKFVTDAFFKKDFFEFTAGIACQYHEDNDRTKYCTQSMVTRWAYTFSDFMCGDLAITVQPGKHIPAHTKPNYRIISSDASSLAHESSFDSFYSLPGSRVKKENQSEDVLLSSSRPSVESSSYTPTDHTAFTADLSKLCEFPSLGMRNSSKHRGLDVSAQRERNAGAWNLPTHSRSIQKFSDNDFSVTGADGKHKN
The following text describes a protein:
Function:
[Isoform a]: Required for embryonic morphology and development. Plays both a functional and a structural role in the maintenance and probably biogenesis of fibrous organelles, a hemidesomosome-like junction structure, which ensures muscle stability and muscle connection to the external cuticle.
Subcellular Localization:
[Isoform a]: Apical cell membrane; Peripheral membrane protein. Basal cell membrane; Peripheral membrane protein. Cytoplasm. Cell junction, hemidesmosome. Note=Co=localizes with cytoplasmic intermediate filaments; [Isoform e]: Cell membrane; [Isoform i]: Cell membrane; [Isoform j]: Basal cell membrane. Apical cell membrane. Cytoplasm. Cell junction, hemidesmosome; [Isoform k]: Cell junction, hemidesmosome. Cytoplasm, cytoskeleton. Note=Co-localizes with actin.
Sequence:
MTSHIATETSVNRWSTEPVVREEGRPPGPEDFPSTKQGREQDGNVIGITPNYKIGEQKPNSELNLGKTGSLPRGSGDYKMTYRQEDYKQTIIDPKVITNANMPYISTRIPDPRRNLAGDFPSEHSKSKIKLDPLEQRRFRSSESRPITTSNYLAESVDRHREMEASRLREYLKAKENEANQPWNKPGWPGPKKNDESLRELETMKQRIETLKRDANKGPVNAELDELSKRAEELRKRDGWSKYKLVESDIYKTDPDPMPANIKDQVRDLLESRNSVETTTTQRDHDKSGYVTDVSTATWNFSTVDYSPRSVVSMNGASHDILKDDKPRSIMKRNDLVRREQMLYPTVDTQVVKSVVKKPTVTETVQRFEETRRTEEVERRVQRREKKERRSRHHSSSRHHSGWEGHTGGYQGHRSSSLSRGGHGGGGQETYYRQETTRRQQHNNYDDNFNRGIAHARYGSLSDSLRRGELQYVPNGEVRQSFYRDGSNGGQRMHKSYSTRDVFTGDGYDDRRSVSSFRRGSQQQVSPFVEFPPTLPRRGGGGDYRREEDAYFRPVSKSRSYADWDDAGRAGMGREVRRYDDDMSRLEAEFRDSLLMPMPAGNMNERDHRTEQLPGGYETFNKERHANSGRRSGRDGKPVDFNEATQEYNYKREQTLNDDRRRR
The following text describes a protein:
Function:
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKPTRIEDYTYLRHVEWVTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVANGFLPAAQGRTPLPFYVWRAFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDDPAVPANRAAWEALGRWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIKASHFIQEDSGTELAERMLSWQQAT
The following text describes a protein:
Function:
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (By similarity). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Colocalizes with pre-60S rRNP particles.
Sequence:
MADSLLLLKRVPSRHTWLRARKARPQLMLSRRPRRRLRNLRWRSRRRLRRRLLQAQAAGADWLQGGCLVSGDAALQRLKTSARRRASSPEPAEDPVPSGPAILPIPPVRPAGSGRAVLLLPLGQGFTFSGICCVTCLYGQVQVFGFTISQGQPAQNVFSTYTHSRLTINAVHYSVHEKSKKEMKREARVLLRPYLNQDDRYCLMSSFSPLCSIVLLERLKTSTVNFIISHPGLSYIFVQEVRTFQINSEYFALRSVGIRREKKKTGLRLTESAFAVMEELVSISSEEADSCPVILVCGCQDIGKSTFNRYLINQLLNSVSCVDYLECDLGQTEFTPPGCISLLNITEPVLGPPFTHQRTPQKMVYYGKTSCKNNFENYIEVIKYVFSSYKRESPLIINTMGWVADQGLLLLIDLIRLLSPSHVVQFSSDRSKYMPDLTPDFVDDMDGLYTRRRSRVRNRGFHLPEFAESLEFADEEKEGPVMSTGYKLMFVKSEFVTGKTSRNRESHNRILRELAVLGYLSQLQPPVPKPLRALHGLTPYQVPFNAVALRIIHADVAPTHILYAVNASWVGLCKILDDVRGYASGPILLAQSPICDCVGFGICRGIDMEKKLYHILTPVPPEELRHVNCLLVGAVNIPQCVLKSQGGLEGTIPYVTTDYNFKLPGASEKIGARESGATYKEKGHPKPKFYRKTY
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MASYLLSQFLERVGELPGELDRKYSDLRTLDQDVQSLLVEIDQGCNQLLQDLGKVTGPERMRRLRHLRSQFEDALDMSDRKIALAVDSYETVDKHIRDLDGDLSKMDANQALTEGAQAVAQKKEEMAIDPNEPRYCICNQVSFGEMIGCDNEDCPHEWFHYACVGLTEKPKGSKWYCPNCRGHMASKRRKK
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Cytoplasm, Stress granule. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cell projection, dendrite. Note=Shuttles between the nucleus and the cytoplasm in a xpo1/crm1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (By similarity). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity).
Sequence:
MADRRRRRRRASQDSEEEDESASGSESGRSFSASRKTRGREPEPVESPAERVAAKSDDESECVSEDGVGEAVLSDYDSADLEENGSHTEGGEEEEEAEHFSEEEASRPAAESKPVADAPTEELVEGEERDESVKEVKADEKGNLAGERQSGDGQESTEDPENKGSKGQKLDDDEDRKNPAYIPRKGLFFEHDVRGQATEEERPKGRNRKLWKDEGRWEHDKFREEEQAPKSRDELIAFYGYDIRNGTGPSDGRSYRSRKPRHAGSPSREPRRYREGDKSVRSSWQGPPPGHRNAPQSVTVQSGQPLAPLSAPKPSGRPSTQPPQRSFQGSRAPSAPHRTEGRGPSKPSLDGAPLRGPRSQPVEGERGPRLRGRSSHAVHADRSPSLVVEDICSEEEEEEGEIPTATTTYTAHHYKTEKERVPSPRKQDSGMVMEGGSAAGQVRELSPPQERQVEKKSYSRARRATRTRPSDLSKQASLDDSSSAVQQAPVAAKSESWQEQSEAGTQSGLTGLDQDLARLSLTGQNWAQNPPSYLQAEMRGIRGSMHMAGGPPQYGNMEDMGVGGGRAKRYSSQRQRPVPEPAPMHIGVMEGHYYEPMTFQGPIYTHGESPAALPPQGMLVQPEMHLPHPTHPGLHPHQSGGPLPNPAIYAAPPVSLSPGQPPPQQLLPPPFYPPPGVMTFGNTNYPYPAGGTLPPMYPNPQAQSQVYGGVTYYDTIQQQAQPKRSPPRRSSNPVTVRPPPPEDQSRKAAEEIRS
The following text describes a protein:
Function:
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQPRKAVVVTGFGPFGEHTVNASWIAVQELEKLGLGDSVDLHVYEIPVEYQTVQRLIPALWEKHSPQLVVHVGVSGMATTVTLEKCGHNKGYKGLDNCRFCPGSQCCVEDGPESIDSIIDMDAVCKRVTTLGLDVSVTISQDAGRYLCDFTYYTSLYQGRGRSAFVHVPPLGKPYNADQLGRALRAIIEEMLGVLEQAEGDISCCRQL
The following text describes a protein:
Function:
Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk; [Isoform p78]: Has an essential role in control of cell proliferation and differentiation during development and could act as a tumor suppressor; [Isoform p127]: Has an accessory function in control of cell proliferation and differentiation during development.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm. Note=In larval and embryonic neuroblasts, detected in the cortex with apical enrichment from late interphase to metaphase, and uniform cortical localization during anaphase and telophase. Localizes to the posterior cell cortex of the developing oocyte in a process dependent on the type-1 phosphatidylinositol 4-phosphate 5-kinase sktl.
Domain:
The phospho-regulated basic and hydrophobic (PRBH) motif is necessary and sufficient for interaction with phospholipids permitting cortical localization. Phosphorylation of the PRBH motif by aPKC inhibits the association of the protein with the cortical membrane.
Sequence:
MLKFIRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWEPVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSYATWSIDNPEPPSNVNYVPYGPDPCKSINRLYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTFENNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISMNLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGRSTRTNQSNQVPTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEPLENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNISNSPNQANETISSSIGDITVDSVRDHLNMTTTTLCSINTEETIGRLSVLSTQTNKASTTVNMSEIPNINISNLEDLESKRNTTETSTSSVVIKSIITNISHEKTNGDNKIGTPKTAPEESQF
The following text describes a protein:
Function:
Probable transcription factor, acting as a progenitor identity factor regulating the development of lineally-related embryonic cells including glial, excretory and neuronal cells. Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. Acts cell-autonomously to establish a neuronal left right asymmetry, possibly promoting asymmetric expression of the helix-loop-helix proteins ngn-1 and hlh-2. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons.
Subcellular Localization:
Nucleus.
Sequence:
MTTNFYTAFPTLGYTAYPQFAFAAATTAPSLTSATTSSTTMAPMAPNSESGRRAGRRERTSFNRGQLDQLEKVFRETQYPDVHRREALAKAINLPDGRVQVITVWFKNRRAKDRNNKKMDGVHPGSTSSRSSNGSPHNESKPDTKSLGIHIPGTPEFNAHSAAKYEANSAVLSQLQQQQQQQLQQPKSELEDSKPLADTKYDSTQSLLPQAQAAAYASYATTAPYPYNYNSYFPSNFYYQQYGSNDYTPNITAYSPL
The following text describes a protein:
Function:
Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTHLKGFDLLALGFMTFALFLGAGNIIFPPSAGMAAGEHVWSAAFGFLLTGVGLPLLTVVALARVGGGIGRLTQPIGRRAGVAFAIAVYLAIGPLFATPRTAVVSFEMGVAPFTGDGGVPLLIYTVAYFSVVLFLVLNPGRLVDRVGKVITPVLLSALLVLGGAAIFAPAGEIGSSSGEYQSAPLVQGFLQGYLTMDTLGALVFGIVIATAIRDRGISDSRLVTRYSMIAGVIAATGLSLVYLALFYLGATSQGIAGDAQNGVQILTAYVQQTFGVSGSLLLAVVITLACLTTAVGLITACGEFFSDLLPVSYKTVVIVFSLFSLLVANQGLTQLISLSVPVLVGLYPLAIVLIALSLFDRLWVSAPRVFVPVMIVALLFGIVDGLGAAKLNGWVPDVFAKLPLADQSLGWLLPVSIALVLAVVCDRLLGKPREAVA
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MWLSKDKTFFCSQMKRAYTHPISSVNFQDYELLAKLAWEEDCPEEDITSVSLFSIDQNATANLNSREPGILCGTGVLEVLNTLSGNKIRSELFKKDSESFQAGETLLKIEGSLVQILRIERILLNFIQYLSGISTTTGEVVKKYGQKGLMILDTRKTLPGYRKLAKYAVYCGGGSNHRLNLSEMAMIKDNHLAMYSSAREPVEKIKLSFPNKLVEVEIDSILQLEDAISSGAEVILLDNFSLEDSKTAYSILKQKAPNVLIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLDIERH
The following text describes a protein:
Function:
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKRRASDRGAGETSARAKALGSGISGNNAKRAGPFILALCAVGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSNADSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSIHDARSWVPKRQFGSAPPVRRLGHDAQPMTSLDTAILAQRYLRK