lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion matrix.
Sequence:
MKSLLPVQPESPRLLRVAIVGEPNVGKSTLINELMRWKVCSVSKKVHTTRHNAKAVFIDGDTQIVFLDTPGIVDLKHSRKHHLGATMVVDPEHALLNADAIGVMVDASDHWRRQRIEENLLRLLRFNENKQSFLIVNKVDLLRSKRQLLECIHSLTEGVVGGVPTRRQKPRNPKINADDLFSKTEAKLRGREIEDEAQGSSQESSTEPHNGWPNFSEVFMISALNNDGVDDLRSYLLQAARPSEWMYPKELVTDQNPHEIATMIVREKILNYLAKEVPYNLDISVTMWDVDSSGVLHAVITIQGHQDRYIKYAIGDKGKTIQKIAAESRQDLASIFHCDVSLKLVVNRL
The following text describes a protein:
Function:
Probably together with ced-9, plays a modest role in preventing ced-4 and caspase ced-3-mediated apoptosis.
Sequence:
MPGGMGFPSDPALLPRVQAHIRKFPGTKYFKPELVAYDLQQEHPEYQRKNHKVFMGMVREALERIQLVAKEENDEKMEEKEAMDDVQEIPIVKALETRKRKAPAAGRKSTGQAAAAKEVVLSDDSEDERAARQLEKQIESLKTNRANKTVLNLYTKKSAPSTPVSTPKNQATKKPPGASAAPPALPRGLGAVSDTISPRESHVKFEHIGGADRQFLEVCRLAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELVLPPREKPLKDQLTFGDDGSVAIIGDSPTAAGAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILEKICKVNLAGDVTLKQIAKLTPGYVGADLQALIREAAKVAIDRVFDTIVVKNEGHKNLTVEQIKEELDRVLAWLQGDDDPSALSELNGGLQISFEDFERALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDALVPKRSHGESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNGTRPMLGEDIDFHEIAQLPELAGFTGADLAALIHESSLLALQARVLENDESVKGVGMRHFREAASRIRPSVTEADRKKYEHMKKIYGLKQATPPSV
The following text describes a protein:
Function:
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
Miscellaneous:
MISCELLANEOUS: The midpoint reduction potential is 25 mV.
Sequence:
MAEPQDMWRCQMVNCGYVYDPDRGDKRRKVPAGTKFEDLPEDWRCPVCGAGKKSFRRLSDEA
The following text describes a protein:
Function:
E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferons stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus or rotavirus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDEELYSRQLYVLGLPAMQRIQEAKVLLCGLQGLGAEVAKNLVLTGVGSLTLHDPHPTCWADLAAQCFLSEESLGRNRAEASQAQLAQLNEAVQISVHSGDITEDLLQGFQVVVLTDSKLEDQLKVGPLCHKHGVRFLMAETRGLVGRLFCDFGEDFTVLDPTEVEPMTAAIQDISQGFPGIVTLRGDTKRHSFHDGDLVIFSDIEGMVELNSCSPQSVRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVRHKPLDIALLQPHVVAQNTQEVQRAHCLHQAFHVLHKFQQLHGRLPKPWDPDDAETVVELAQDLEPLKGTEEESLDEALLRTIALSSAGTLSPMAAIMGGVAAQEVLKAISRKFMPLDQWLYFDALECLPEDETLLPSPEDCQPRNCRYDGQIAVFGTDLQEKLSDQHYLLVGAGAIGCEMLKVFALVGLGVRANGGVTVADMDYIERSNLSRQFLFRPKDVRRPKAEVAAAAAHRLNPDLRATPYTCPLDPTTEDIYDDSFFSRVNGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTWGSASVFVPYVTEAYRGPASDAASEDAPYPVCTLRHIPSSMEHSVQWAQDQFEGLFRLSTETINCYQQTCTSLSATDRTETLALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFHDKVLEGGTQFSSGSNKCPHPLQFDPNHDMHFLYVLAAANLYARMHGLPGSQSQPALRELLTRLLESDSRPQNLFSAEHGQEQLKELQETLDDWRKGPPLKPVLFVKDDDSNFHVDFVVAATDLRCQNYGILPVNHARIKQIVGRIIPAIATSTAVVAGLLGLELYKVVSGLRSHGTFRHSYLHLAENHFIRSAPSAPAVQSFRDLKWTCWDRLKVPAVQPERTLKSLLAHLQEEHGLKVEMLLHHQALLYSSGWSSEKQAQHLCLRVTELVQHVTGWKPKPGLKVLVFELSCEGEEEEMAFPPLHYEL
The following text describes a protein:
Function:
Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
MGPRGTAHSVRAPLSWLLLLLLSLQVAVPAGALAETLLDAPRARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENFGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIQTVDVFAGIANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSSNRERRASTSTSRYLSLPKNTKLPEKLQKKKKVSNADGNSSDSDPDVGTTVLNLQPRTRRFLPDQFSKKASQAYKMEWKNEVDVGSVRVPPSVSPAPRSKDGGTQTPGLLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRRASEPGNRKGRLGNEKP
The following text describes a protein:
Function:
Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation.
Subcellular Localization:
Cytoplasm. Forespore membrane; Peripheral membrane protein. Note=The sporulation-specific septin complex associates to the forespore membrane and forms partial or complete ring-like structures that curl around each haploid nucleus.
Sequence:
MSLTENLQLLLNLDSLPSKRENLIKRKECGLTIMLCGASGTGKTTFFNTLFATSLQPEKSYETAKETIAKKTLEVKKNKAVIEEDGFHINLTVLDTPGFGDFIDNTSCWNTVAEYLDEQHERYLIHDQNSLRVPRKDTRVHVCLYFITPVSFGMLPLDVLAMKELSTHVNLVPVIAKADTFTTPELTQIKQKIRRILEAQSIDVFHPSTEYSDYETAELLDSSLPYAIISSVNEVCKDDGEKSQGRRYPWGTSEIYEETHCDFLKLKKLLINRHMLELINTTETNIYERYRREQLTNRKSGIPKLKKEHYERLNNEKRAIQQKITQMTNETESFFQAKEEKMIETRDALNSELSEYHERIRALETQIESLKSYKGRGHKK
The following text describes a protein:
Function:
Histone acetyltransferase (HAT) subunit of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing and G0 control.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MARSLSQSLTATTQKLKGKKNGGKGKNKPSAKIKKTQKEMLYGILNERNIRQIQFGLNKKFSTWYGSAVYFDPETKRLGCSETKGQLSSVSNSQYWLDTLFVCEYCFKYTDDQTRFVGHVASCPFQYRVPGKIKYKSPEYTIRRVKGSKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIVYETGSTKPMGFFSKDLVSYQQNNLACILIFPPYQRRGLGLLLIEFSYKLSQLEGVISGPEVPLSPFGLIGYLKYWSQILCWHLIEGDLAHYDKVTLEDLSIVTGMRVNDVILTLKHLNCIGENNQIYLQSLNSWLKLHGTKRNWFKLKDEYLLIDD
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MLQGQKSFALDTAIGMWQLLFAEREWPLVNHWCDFLQDRHNKTISKDTWAQLLEFARTVNPLLSNYDAEGAWPYLIDEFVEYLYDKSVVDK
The following text describes a protein:
Function:
Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.
Subcellular Localization:
Mitochondrion.
Sequence:
CTHPHHPASFMAPWDIRQQILLLYRRILQTIWQVPNDCDCKYLKDWAREEFKRNKSATEEDTIRMMITQGNMQLKELEKTLALAKS
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAGAGATMATATAPPLRGRVTRRPHGVRPRCAAAGSATETPAAPGVRLSADCVIVGAGISGLCTAQALATRHGVGDLLVTEARDRPGGNITTVERPDEGYLWEEGPNSFQPSDPVLTMAVDSGLKDDLVFGDPNAPRFVLWEGKLRPVPSKPGDLPFFSLMSVPGKLRAGLGALGIRPPPPGREESVEEFVRRNLGAEVFERLIEPFCSGVYAGDPSKLSMKAAFGKVWRLEEIGGSIIGGTIKAIQDKGKNPKPPRDPRLPAPKGQTVASFRKGLAMLPNAIASRLGSKVKLSWKLTSITKADNQGYVLGYETPEGLVSVQAKSVIMTIPSYVASDILRPLSIDAADALSKFYYPPVAAVTVSYPKEAIRKECLIDGELQGFGQLHPRSQGVETLGTIYSSSLFPNRAPAGRVLLLNYIGGSTNTGIVSKTESDLVEAVDRDLRKMLINPRAADPLALGVRVWPQAIPQFLIGHLDRLAAAKSALGRGGYDGLFLGGNYVAGVALGRCIEGAYESASQVSDFLTKYAYK
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded. The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA. This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle.
Sequence:
MTSIQLNDTERQLSDLLVKFGRDWDAKNGGSDPLTLRFTGGWVRDKLLGQNSNDIDIAINSLTGAEFVDQLHAWISANPGSYPDELRSKHTIKLNPDKSKHLETATTNLFGLDVDFVNLRSEEYSDESRVPVVQFGTAEQDAYRRDATLNALFYNLQEKKVEDLTGRGLADLEEGILRTPLAPKQTFKDDPLRVLRLIRFAARFNFQLAPEAIEAIVSGEDIKHALETKISRERVGIELDKMFSGPCPEYGLRLIAKLGLEHEIFGLPDKYATKDTTKPIFHLSRAVDTWEAIRSSENLHINLLTAYSGETKKMIWALCALYPWDKITAVTEKNKPCLALFMIIREGIKWSTHDGDVITAAINTVDAIEEAVEGVNGGNKPSRADLALLVRKCGEHWTANVLFAAQKTIVSGADMESTLKRYSALVDAIVDQKVDDSWSVKPLVNGKEIMATLQAKPGKWLATLLNDVVVWQFTNPEGTKKQCLDYVVERKKQLE
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Subcellular Localization:
Cell membrane.
Domain:
The helical domain is required for self-activation.
Sequence:
MLSIITQNMGSLCSKQRRCNEADAEENAQAAEIERRIEQETKAEKHIQKLLLLGAGDSGKSTIFKQIKLLFQSGFDEAELKSYIPVIHANVYQTIKILHDGSKELAQNETDSLKYVISNENKDIGKKLSEIGGRLDHPRLTKELAQEIETLWRDAAVQETYACGHKLQVPDCTPYFMDNLQRLSDSNYIPTKEDVLYARVRTTGVVEIQFSPVGENKKSGEVYRLFDVGGQRNERRKWIHLFEGVTAVIFCAAISEYDQTLFEDENKNRMIETKELFEWVLKQPCFEKTSFMLFLNKFDIFEKKVLKAPLNACEWFKDYQPISTGKQEIEHAYEFVKKKFEELYFQSTTPDRVDRVFKIYRTTALDQKLVKKTFKLVDETLRRRNLFEAGLL
The following text describes a protein:
Function:
May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQVLVTLWCLICTCLVLPVAAKKRTLTASSLVTCMENSQLSANSFDVSFSPDDRSLHYDLDMTTQIDSYIYAYVDVYAYGFKIITENFDVCSMGWKQFCPVHPGNIQIDSIEYIAQKYVKMIPGIAYQVPDIDAYVRLNIYNNVSENLACIQVFFSNGKTVSQIGVKWVTAVIAGIGLLTSAVLSTFGNSTAASHISANTMSLFLYFQSVAVVAMQHVDSVPPIAAAWSENLAWSMGLIRITFMQKIFRWYVEATGGSASLYLTATTMSVLTQRGLDYLKNTSVYKRAENVLYGNSNTLIFRGIKRMGYRMKIENTAIVCTGFTFFVLCGYFLAGFIMACKYSIELCIRCGWMRSDRFYQFRKNWRSVLKGSLLRYIYIGFTQLTILSFWEFTERDSAGVIVIACLFIVLSCGLMAWAAYRTIFFASKSVEMYNNPAALLYGDEYVLNKYGFFYTMFNAKHYWWNALLTTYILVKALFVGFAQASGKTQALAIFIIDLAYFVAIIRYKPYLDRPTNIVNIFICTVTLVNSFLFMFFSNLFNQKYAVSAIMGWVFFIMNAAFSLLLLLMILAFTTIILFSKNPDSRFKPAKDDRASFQKHAIPHEGALNKSVANELMALGNVAKDHTENWEYELKSQEGKSEDNLFGVEYDDEKTGTNSENAESSSKETTRPTFSEKVLRSLSIKRNKSKLGSFKRSAPDKITQQEVSPDRASSSPNSKSYPGVSHTRQESEANNGLINAYEDEQFSLMEPSILEDAASSTQMHAMPARDLSLSSVANAQDVTKKANILDPDYL
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
Miscellaneous:
MISCELLANEOUS: Present with 4240 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDCPSNVVLLLLQLVLQRQQTLAHRDKSVDLQTLLKDPVIDNDVLVEFKTHKLVQLYGPQYCRDISLRGLKTMVTDIFANGIPKNAQSSGNDQPVTVVDLANYYYMQRINELQNTELPQLKEALLTRLEHMI
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MVGAQGSTMPAAEAGMDIELSRGSWAPNFAFAFDSERFSDKVLRIEIVANSEVAGGGSLTEPASQRAEEEQIQEALQALECCGLSPICNCLDLVCIYCTTIDANNVARVLLALVGRMNTCSPSGVTTDEGQSIDSSSTMAAKAISAVKALYINSAILAARSPFFQKLFTNGMKESDESHPRIRIADSEENSLMELLRFMYSGKLTTIEPTLLLDILMGADKFEVPACMRYCSQLLISRPMTTESALLYLGHPCSILMAAEVQSLVRAAKGFLANKYKDFDMFQDELMNISLVGIEAIFSSSDLHVLCEDVVYYFLLKWARVRYYYSEEERRKVLSYRLLPLVRFSNMSCDALQKVLRYEDVDIDHEYLTKHIAEVLLHKAYPNQMEGALAANVTTCWQFAERAYDFKLVRVVAFNQPCPQVTVYMDLKRDECSRLFPSGGICMQIFHLAGHKFYLLANCKMVEQATSYSFALSLNIFDEPAGSICLDIEFAARTKPLGKFVSKYGYKNTMTGDRSQGCGDLFGMPWSTFIADDSLFIDGVLYLRADLTLVVQPELQT
The following text describes a protein:
Function:
Member of the two-component regulatory system CarS/CarR that regulates the expression of multiple genes involved in calcium signaling and homeostasis including CarO and CarP. May function as a membrane-associated protein kinase that phosphorylates CarR in response to environmental signals leading to activation of specific gene promoters (Probable).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRSIQRRLSVGLFAVLLVVGLVLAQTGLWLFDQGLRRYFAGNLREEAENLLVAMVRGPNGMQLDEQRLNPAFQRPYSGRYFVIELEKDTWRSRSLWDSELEVPHKKGLVQGLVDGPEEQRLLVFRGHYKRMGQKLRIVVAQDYTPILESFARVQWMGLGAGALALLLVLLLQRLTVRRSLRPLEEVRLQIAQLQQGQRSQLDNQAPEELEPLVEQINHLLAHTEETLKRSRNALGNLGHALKTPLAVLVSLAEREEMARQPELQQVLREQLEQIQQRLGRELGKARLVGEALPGAHFDCAEELPSLCDTLRLIHGPHLQVSWSAPPGLRLPWDREDLLEMLGNLLDNACKWADSEVRLTVAQGEGMVRLKVDDDGPGILPDQRQAVLERGTRLDEQVSGHGLGLGIARDIAEACGGRLSLEDSPLGGLRVSVELPLQKSGRAARA
The following text describes a protein:
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular Localization:
Nucleus.
Sequence:
MSGGVFGDDIFSLVFDIGSNSFRVGYAGEDQPRGDFPTSVGVLDLKETRNEEGNFVTKQDKYVIDVVNLNVPREGMEVTSCLKEGMVEDWEIFEKQIEYAYGRFIETPSEYHPVLMTESAWNVRSKREKLLELMMEKFNIPAFFLVKNATLSVYANGRTSGLVLDSGATLTSAVPVYDGMVIQHGIVKSPLAGDFILMECKKLLDEMGIEIVPPFYVAHKEQVPEGQPPIWKKRENIPEMTKSHFNYSIKDVLKDFAAQTLQVSDSPYDESVFENMPTHPYEFHTGYNYVFNHERFKIPEALFDPSLIKVDAHGGSSMLSMSHIVSTSVGFCDIDIKPSLYNNVIVVGGNTLLNGFVERLTRDLSAKTPSSMKLKIVSSPVASERKYSSWIGGSILGSLSSFPQMWISKQEYEEAGKIIVEKKCV
The following text describes a protein:
Function:
Nickel and cobalt resistance proteins CnrA, CnrB, CnrC CnrH and CnrR may be involved in the regulation of CNR; CnrH alone is able to activate cnr expression, and both CnrY and CrnX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift, PubMed:10671463 or absence of the transcript, PubMed:10671464), nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MADVEEWLTHARKVTQEASIGVDVTSIQECISAEPAQRVLVARRDAWRAICCAAFAALVAFAAINRVATIMLEKPAPTWVATPSAASPFGLLIGK
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid. Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol). The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid. Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton. This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid. Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order. The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21. C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation. The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC.
Sequence:
MAVATLISILFAVLALRLCYLLIHALFLSPLRHIPAPFMARVTSKRPLWHLLTGKAEIAARQDYSTFGDIYLCKPNTVYLCDPHDACTVLSSHAFRKTDMYRVFEYEGIPNVSTFTDPAQAQRRRRQLHPFFNNAYLTQMEPVMLKYGIQALKARWDAQLARHKKVEVNYRFDTQLAMFDITGALVFGREFHALETSNLVYTKWVNNTLSYMLVSHYFPWVKRVPLSWLVRGLKQSYDDLVAFSQESIAIRQADLQAGRPKPADLLQALLDAEDPDSKAPMTAREVQAESIAMLVGGSESTSSVISWVIHFLLLYPEHLQAVVAETRANFPADHTITFNESKANLPYLEACIYETLRCIPTASTSFPRVSDQAIILKGYYIPAGTEIATNKCAAHLHQPSWQDPDRFYPPRFLNQETYHETRRNMLSFAYGTRFCIGRNLAWAVMMVTLANLFKDYEVELPEDSRFGPTIVDAAGRPKIMPTKMGVATMPADPERDCRMVLSVRITE
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butyl acetate, isoamyl acetate, and hexanoic acid.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYSPEEAAELKRRNYRSIREMIRLSYTVGFNLLDPSRCGQVLRIWTIVLSVSSLASLYGHWQMLARYIHDIPRIGETAGTALQFLTSIAKMWYFLFAHRQIYELLRKARCHELLQKCELFERMSDLPVIKEIRQQVESTMNRYWASTRRQILIYLYSCICITTNYFINSFVINLYRYFTKPKGSYDIMLPLPSLYPAWEHKGLEFPYYHIQMYLETCSLYICGMCAVSFDGVFIVLCLHSVGLMRSLNQMVEQATSELVPPDRRVEYLRCCIYQYQRVANFATEVNNCFRHITFTQFLLSLFNWGLALFQMSVGLGNNSSITMIRMTMYLVAAGYQIVVYCYNGQRFATASEEIANAFYQVRWYGESREFRHLIRMMLMRTNRGFRLDVSWFMQMSLPTLMAMVRTSGQYFLLLQNVNQK
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTDRETEVTMEVKNETTIQEFVLEGFPAVQHLGKFLFLVHLLAYLASITGNMVIITITWVDHRLQTPMYIFLSTFSFCESCFITTVIPTLLSIFLSGRQTIPFTACLTQAFAFLFLGSIIFFLMAVMSLDRHLAICKPLRYPTVMNLRVSFLLVFFCYTLSFIFITGLLVQVSQLSFCGPNVISHFFCDLGALIHLSCSDTRSVEIYIFFLALLVILIALILTFIAYSNIIVTIVRLPSAKERQKAFSTCLSHLIVLSLMYGSCVFTYVKPKQTNRLDSNREAALVNTVVTLLLNPVIYTLQNKQIHQALRKTLSRMRL
The following text describes a protein:
Function:
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Sequence:
MGKEYFLKVALREAKRAFEKGEVPVGAIIVKEGEIISKAHNSVEELKDPTAHAEMLAIKEACRRLNTKYLEGCELYVTLEPCIMCSYALVLSRIEKVIFSALDKKHGGVVSVFNILDEPTLNHRVKWEYYPLEEASELLSEFFKKLRNNII
The following text describes a protein:
Function:
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Sequence:
MSKKEFFVDMTCEGCANAVNRVLSRLEGVQYEIDLPNKKVVTESDLSVDLLLETLKKTGKEAKYLGCK
The following text describes a protein:
Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.
Domain:
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence:
MATFRNNHMKTKASVRKSFSEDVFQSVKSLLQSQKELCSVTAEDCLQQDEHANLTEVTFLGFNEETDAAHIQDLAAVSLELPDILNSLHFCSLNENEIICMKNINKPLDISSDPLNQSHPSGMLCVMRVSPTSPRLRIDFIFSLLSKYATGIRYTLDTFLHQKHQLETTDEDDDDTNQSVSSIEDDFVTAFEHLEEEETSKPYNDGMNITVLRSQCDAASQTVTGHHLETHDLKILISSGQQKSLAKPSTSSVNVLGHKELPSVKTSVTTSISEPWTQRSFYRSSNASDKDSDLQKTFFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLELPKIPVMKDDIEDSDSEVSEFFDSFDQFDELEQTLETCLFNKDPVIGKSSQRKGHKHGKSCMNPQKFKFDRPALPANVRKPTPRKPESPYGNLCDAPDSPRPVKASREDSGLFSPIRSSAFSPLGGCTPAECFCQTDIGGDRIHENHDSVYYTYEDYAKSISCEVLGSVLRTHHTNTLSNINSIKHGENKTVTFKHGNLDQKNKSKNKSLMIKDSIQKFAADLVEKSFGSAFKDLQKGVSSCTNALYHLAIKLTSSVLQMAFDELRRQRAFSLKERAISGLANFLVSEALSNALKDLQYVKKQIFTNTVARFAADLAEELVFEGIMEVCQFSYPQTPASPQCGSFDFEDKVVKLYAKDLSESVIQEAFIELSQVDVTFTTKAAVSVSTDNIKYVSAESVVPSTQAVTFSPSFHNQAIMVTKPVQEYKKEYTVQQALFCTSGIVTSIPVPLAGSALLPYHISSTACQAKAHLSSDDSNSNGDSAQVHIATKNREEKAACLRNICLPSEHNPGNQNDFKPTNDDIEMQSSSKLPNDPAIISNFSAAVVHTIVNETLESMTSLEVTKMVDERTDYLTKSLKEKTPPFSHCDQAVLQCSEASSNKDMFADRLSKSIIKHSIDKSKSVIPNIDKNAVYKESLPVSGEESQLTPEKSPKFPDSQNQLTHCSLSAAKDCVPECKVSMVHGSSLETLPSCPAVTGQKSDLKESAKDQPLKKHNLNSTSLEALSFGQENPFPHSHTFSSTALTCVDGLHVEDKQKVRDRNVIPDTPPSTPLVPSRASSEWDIKKLTKKLKGELAKEFAPATPPSTPHNSSVGSLSENEQNTIEKEEFMLKLMRSLSEEVESSESGELPEVDVKSEHSGKKVQFAEALATHILSLATEMAASHLDNKIIQEPKVKNPCLNVQSQRSVSPTFLNPSDENLKTLCNFAGDLAAEVITEAEKIAKVRNCMLFKQKKNSCYADGDEDYKVEEKLDIEAVVHPREVDPFILSLPPSSCMSGLMYKYPSCESVTDEYAGHLIQILKQEGGNSELIMDQYANRLAYRSVKSGLQEAAKTTKVQCNSRMFPVPSSQVKTNKELLMFSNKEHHQEADKKRQSKRNEGYFCKNQTCERTLDPYRNEVSQLYSFSTSLVHSITKDAKEELTASLVGLPKSLTDSCLFEKSGYEEDNECHVTPELPKSLQPSSQNHRFYHSTGSLNGYGCGDNVVQAVEQYAKKVVDDTLELTLGSTVFRVSETTKSADRVTYAEKLSPLTGQACRYCDLKELHNCTGNSSQHFFRQGSLASSKPASNPKFSSRYQKSRIFHLSVPQIHVNLDKKAVLAEKIVAEAIEKAERELSSTSLAADSGIGQEGASFAESLATETMTAAVTNVGHAVSSSKEIEDFQSTESVSSQQMNLSIGDDSTGSWSNLSFEDEHQDESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTSDSDGPDDKDEEHEDEVEGLGQDGKTLLITNIDMEPCTVDPQLRIILQWLIASEAEVAELYFHDSANKEFMLLSKQLQEKGWKVGDLLQAVLQYYEVMEKASSEERCKSLFDWLLENA
The following text describes a protein:
Function:
The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRCEVPLPLLGLLLCVVGAAAQGGQEEFAVEISGTTVTITCPSSGDDVKWKPDPKMVVNNKYIIQNHDSSPLTVSCTAGDEEHTMYLNAKVCANCEELDTFTVVGIIAADLLITLGVLILVYYFSKNKKGQSRAAAGSRPRAQKMRRPPPVPNPDYEPIRKGQRDVYAGLEHRGF
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAAENSSNAINVDTSLDSDSKPNRDANDMTDHDSSSKALVIPAPAVCLVRFAGDAASGAFMGSVFGYGSGLFKKKGFKGSFVDAGQSAKTFAVLSGVHSLVVCLLKQIRGKDDAINVGVAGCCTGLALSFPGAPQAMLQSCLTFGAFSFILEGLNKRQTALAHSVSFRQQTRSPQHDLPLLSLAIPIHDEIKGAFSSFCNSLTKPKKLKFPHAR
The following text describes a protein:
Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.
Sequence:
MPSTIKELFCVGRVPGFIDVLEFQDYSEASLKPHMPADTTEEVVVMLYTSGTTGLPKAVQVSHKAYVSCYRTLMASGLFLEDDAILAWNPFTHASGFVIDTICVCLGATVIVTEPSLSCTDFLETLSTHQISVIFASSERLREILNEARTNNHPAVGLKKIIVGGTALAESLGTELCKFFGVNSFVNFYGLTEAFPLVSCTPPGKISMDNVGVPCAGTKVKTPGGLEALYSIFVLIEAN