lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for normal function of hair cells in the inner ear.
Subcellular Localization:
Cell projection, stereocilium.
Sequence:
MMAQKKKRRKKDIDFLGLYEEELLNYDSEDGEDELEHEYYKAKVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESAFEKANVDVFRVRTNNVGLIYKIRIEHDNTGLNASWYLDRVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLLASFDPMDMPRGNKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAPDLGQLMKINVGHNNKGGSAGWFLSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVGGAETTAITYIVTVFTGDIRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKYPWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGWHLEKMTLMNTINKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLPSDSNATLKNFRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGTINRLVIGHDSTGMHAGWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKVFDRGSKDIFQTDTFTIYAIDLGALTKIRIRHDNTGNRPGWFLDRVDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPSEDEEGGGQGDNNPLDNLALEQKDKSTTFSVTIKTGDKKNAGTDANVFITLFGTQDNNGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIVIYGCDAVCTRQKFLCTNKREQKLFFERKSASRFIVELEDVGEIIEKIRIGHDNTGINPGWHCSHVDIRRLLPEKDGTETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDIDTVTGPMVDYVQDGPVIPYYVSVTTGKHKEAATDSRAFVLLIGEDDECTNRIWLDYPQGKRGFSCGSVEEFYVGGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYTLRCNCWLAKDRGDGVTSRVFDLLDAMVVNIGKKVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGMGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAVIDGEEMMEWTSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACANNEIRDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLVENSSRQRAFRKGTTDTFEFDSIFLGDIASLCVGHLAREDRFIPKRELVWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKIQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGWLVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELFPSV
The following text describes a protein:
Function:
Protein phosphatase that acts as a negative regulator of abscisic acid (ABA) signaling. Involved in the regulation of root architecture development and drought resistance. Can dephosphorylate SAPK8 and SAPK10 in vitro. Together with PYL10, SAPK8 and SAPK10, may form an ABA signaling module involved in stress response.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing PP2C53 are insensitive to abscisic acid (ABA), exhibit altered stomatal density and root architecture, and are hypersensitive to drought stress.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Treatment with abscisic acid (ABA) reduces the nuclear localization and enhances the cytosolic localization.
Sequence:
MEDLALPAAPPAPTLSFTLLAAAAAVAEAMEEALGAALPPLTAPVPAPGDDSACGSPCSVASDCSSVASADFEGFAELGTSLLAGPAVLFDDLTAASVAVAEAAEPRAVGATARSVFAMDCVPLWGLESICGRRPEMEDDYAVVPRFFDLPLWMVAGDAAVDGLDRASFRLPAHFFAVYDGHGGVQVANYCRKRIHAVLTEELRRAEDDACGSDLSGLESKKLWEKAFVDCFSRVDAEVGGNAASGAPPVAPDTVGSTAVVAVVCSSHVIVANCGDSRAVLCRGKQPLPLSLDHKPNREDEYARIEALGGKVIQWNGYRVLGVLAMSRSIGDKYLKPYIIPVPEVTVVARAKDDDCLILASDGLWDVMSNEEVCDAARKRILLWHKKNAATASTSSAQISGDSSDPAAQAAADYLSKLALQKGSKDNITVVVIDLKAHRKFKSKA
The following text describes a protein:
Function:
A probable ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.
Subcellular Localization:
Nucleus.
Sequence:
MPPKASNSTEVWINPKLSVKFPFEPYECQRIFMKNVVDVLDRKLDAALESPTGTGKTLSLLCSTLAWVQRQKETKPLDFATWQTSGAGGAEKTDEKLKSAYVPTIFYASRTHSQLEQVVHELNRTEYKWVKTTILGSREHFCINQKVKKIKESNRQAHVCRGLVSKRACHYYNKFDACTTDKMTEFLDKGEAMDIEDFVKLGTQNSLCPYFMSRQRSETAELILLPYNYIIDPKMRRRYKLDLKNSIVIFDEAHNLESICESNASAELTSTSIALCIEELKKVLALLVDEEETARSEADAETGAFGSAKIDLTKKLIENLRTEDLMTVLEKIFSLEEEMDKLFGSSQLKSVPPLSGKASDGEILLETLAKAGFDANSVERLVDVLRDAISYLLSKNEEVALTEKGDGMEKVADFLLSIYSTHAQDVAAAVGEETVKLVDRVDPKTVARNCKLYIQKDKDNEKLTIKYFCFQASISMRMLKMRGVRNVLLASGTLSPIQAFTYNMGLNFGAILENEHALKQVPVLTSIVTRGKRGGLAGSFQNRKNLDYVTGVAEALLRVMEVIPQGILIFFSSYSQMDELVATWKTTKWSSNSNESFWEKMEKTKRVVVEPRAKEELAAIRLRYTQGVSEQHGAALLAVCRGKVSEGIDFCDAESRAVIIIGIPYPPIHDERVVLKKMYLDDLMGRKDTKSERQSSQDWYQMEAFRAVNQAIGRVLRHKDDFGTVVLMDTRYASAKPEMFPKWLRNTISRSDTDGCALKTSRFFKERGHLIENSKTEYIKKQAKQCKSFRQVKQTAASDSKDDIIEITLEDMFSPANMKLEKKEITKLRPPQLIPSTSSVFSLPTNEDELKIKKWEQENDIQCLSSIPLESNKRKFKIETPGPSTSTLTQKSEPPKKKKILLLTRNTLPDEYQKAIEIPTSELLKDMSDDNKKQFATTLRSYKAESIRWDEVFQRFRPIFVPHKADLFIACSNVLRSEDKMKYLKKALESKIHT
The following text describes a protein:
Function:
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
Sequence:
MARVKRAMNARKRHKKVLKLAKGYYGGKSKLFKTANESVIRALRNAYVGRKLKKRDYRKLWIARINAATRMNGLSYSKFMNGIKNAGIDINRKMLSEIAINDPKAFAELVDVAKKQLNA
The following text describes a protein:
Function:
Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate).
Miscellaneous:
MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQAQGSQSNVGSLRSNCSDNSLPNNHVMMHCDESSGSPHSEHNDYSYEKTNLESTASNSREHRDNQLSRLKSEEYVVPKNQRRGLLPQLAIIPEFKDARDYPPMMKKMIVFLIAFSSMMGPMGTSIIFPAINSITTEFKTSVIMVNVSIGVYLLSLGVFPLWWSSLSELEGRRTTYITSFALLFAFNIGSALAPDINSFIALRMLCGAASASVQSVGAGTVADLYISEDRGKNLSYYYLGPLLAPLLSPIFGSLLVNRWPWRSTQWFMVILSGCNVILLTVLLPETLRKQDSKGAIAQILAERRIQVDNNERGEIQEDYQRGEDETDRIENQVATLSTEKHNYVGEVRDQDSLDLESHSSPNTYDGRAGETQLQRIYTEASRSLYEYQLDDSGIDATTAQVTRIRSTDPKLARSIRENSLRKLQTNLEEQVKKVLSSNGGEIAPKQVSAVRKVWDTFFVYFIKPLKSLHFLEYPPVALAITFSAISFSTVYFVNMTVEYKYSRPPYNFKPLYIGLLYIPNSVTYFFASIYGGRWVDMLLKRYKEKYGILAPEARISWNVVTSVISFPIALLIFGWCLDKKCHWVTPLIGTALFGYAAMMTIGATLSYLVDSLPGKGATGVALNNLIRQILAATAVFVTTPMLNGMGTGWAFTMLAFIVLGASSVLIILKKHGDYWRENYDLQKLYDKID
The following text describes a protein:
Function:
Putative protein tyrosine-protein phosphatase.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MTNLVNTNLGFIVYGLIFASFYGSATRIFDIENIPVVKYVAVAGRNVTISCPGVNEHSLIDTLIWKTTQTVAEYVNGSPLVNNPRITLLPGNFSLHISPTSSADTAEYTCLFNDRHSPEAIADLLVQDVPDPPGRPLVVSFTSRSVDLSWAHSQDARNAPVTNFIIETRVGENGDWNQVPPIYTKSHLTTYQVTELLPFTVYSFRIIAVNELGHSTPSKESYYFVTLREAPTGKPVTTIAHNTSATSVYISWKPPPPDTILGEFLGYRITYRTRDRHPDDVKEIYIRDSTVESHEIHNLETYTQYLVSIQVFNPEGLGPPTTVLVMTDEGVPTKPRNLSVLEITSTTIRISWLEPEKRNGVIHGYRVYYVYQNQTLLHLPILKNDAAQNSVFYYTLTNLKPFTDYRIIVTAFTLKYDGEPSEVSLRTDVGGPSPPKVLNLTCHSLDTLFFSWRIPRVYHSSIDFYIVNYRNLEYDDTHEIRISANASIVETSMVIPNLTTNSAYEVKVRGATVSTVNPKKVVLGTYCEPIKIALRANCEQYQPPPLRHNPYDDQELVILAGIVIGCFGLLLIILAIVLWRKCFHASYHEAGDQRPSERTDHKPTVQSNGWKTSCDSNGIVQTSIPSEEYINGQQQAMIDRFHR
The following text describes a protein:
Function:
Plays a role in the inhibition of host NF-kappa-B activation. Mechanistically, blocks the subunit p65/RELA translocation into the host nucleus.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Sequence:
MDTIKIFNHGEFDTIRNELVNLLKVVKWNTINSNVTVSSTDTIDISDCIREILYKQFKNVRNIEVSSDISFIKYNRFNDTTLTDDNVGYYLVIYLNRTKSVKTLIYPTPETVITSSEDIMFSKSLNFRFENVKRDYKLVMCSISLTYKPSICRIQYDNNKYLDISDSQECNNLCYCVITMDPHHLIDLETICVLVDKSGKCLLVNEFYIRFRKNHIYNSFADLCMDHIFELPNTKELFTLRNDDGRNIAWDNDKLESGNNTWIPKTDDEYKFLSKLMNIAKFNNTKFDYYVLVGDTDPCTVFTFKVTKYYINLNYE
The following text describes a protein:
Function:
Involved in the heme and chlorophyll biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MTNIALLQSLGLFDARVPRYTSYPAAPVFSGAVGADFQAQAIEALDPAVPISVYIHVPFCERLCWFCACRTQGTQTLAPVEAYVGTLLQELELVKKHLPAGVKAGRLHWGGGTPTILSPELIHKLAQAIKAVIPFAEDYEFSVEIDPMMVDEPKIRALSEEGMNRASIGIQDFTDIVQSAIGREQPFENTRACVETLRRYGVHSLNTDLVYGLPHQNRESLAATIDKVLQLGPDRVAIFGYAHVPWMAKRQKLIDENVLPNDMERHELANLAAKMFTEGGFERIGIDHFARPDDSMAVAARSGKLRRNFQGYTDDTCPTLLGIGASSISKFEQGYLQNTAATAAYIKAIEEGRLPGYRGHRMTDEDYLHGRAIEMIMCEFRLDLPALRARFGEAAETMVPRITEAAAKFAPFITVDEAGSMSIEAEGRALTRMIARVFDAYETPEARYSQAS
The following text describes a protein:
Function:
Functions as a receptor binding protein (RBP) and probably mediates the attachment to the host capsular exopolysaccharides (Probable). Displays a depolymerase activity that specifically degrades the K21-type polysaccharides Klebsiella pneumoniae capsule, which allows the phage to reach the host cell membrane and bind the entry receptor.
Subcellular Localization:
Virion. Note=Tail appendage (Probable). Depolymerase 1 is connected to the phage tail via an N-terminal anchor domain, while depolymerase 2 is attached to depolymerase 1.
Domain:
Consists in a catalytic region, a carbohydrate binding region and a lectin-like region. The active site consists of catalytic dyads Asp-Glu located at the interface between 2 adjacent subunits. The lectin-like region is probably involved in trimerization.
Sequence:
MLDNFNQPKGSTIGVLKDGRTIQEAFDSLPRLESFSGSTATDKLRAAITLGVSEVAIGPVEGNGGRPYEFGDVVIPYPLRIVGCGSQGINVTKGTVLKRSAGASFMFHFTGEGQAQRPMGGGLFNINLNGDTATALGDIIKVTQWSYFKANNCAFQNMAGWGIRLKDVMESNISGNLFRRLGGPSGGGILFDDVRSAVTDNVNNLHIEDNTFALMSGPWIGSTANSNPDLIWIVRNKFEFDGTPAAPNTVDSYVLDFQQLSRAFIQDNGFTHFTTERNRYVGVLRVGATAVGTIKFEDNLLFACESAGLIAGGIVVSRGNVNNQGSATTAIKQFTNTSSKLCKLERVINVQSNGNVSVGQQILPDGYINMAELPGNTRLPSEYDADGETTSVLRVPANTQVRQWSVPKMYKDGLTVTKVTVRAKGAAAGAILSLQSGSTVLSTKSIDAGVWKNYVFYVKANQLQETLQLRNTGTADVLADGMVFGKVDYIDWDFAIAPGTLAAGAKYTTPNQSYLDVAGMRVQAVSIPMFDGPTTGLQVWVEATSANGSFVVVMKNDTGSELVTTVTRCRVRAFVS
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MFRPTEIHLYKLYVEREQAFHFLTKVGQMNNVNLVNCSNHAFHEHDYYKQLKRCDDIYNKISEVKNLLILYNKPIHYCPNIKSFIQYLQITEDQVIKIEQELTHKVQFIMNQQTNLQQIVEQRNRLEEEIAVIQHCKEFIYKFSGVQLGYIVGCMNAADQHKFNRIVFRISKENGIVKFKDFNNEKIIFTLVFTKGKHENLKTKLLKICEAFNVSIFQLPEEIQIETKINELENELTNLSIVITSTKLEIEEQLDFFSDISAERPLELDEIYFIGYCSYICELKIIVDLVSATYYHLTFFEAKSQFLIGQMWCEPNQIELIKQIGVQIEIMQDINEKLYEPPSLLKTNQFTYIFQELVNTYGIPRYHEINPGLFTIITFPFLFGMMFGDIGHGIVLTFFGFYLLMFGKGVIKSIKLENSSEYLSYADFQSLYECRYLITLMGMFATYCGFIYNDFFSISLEYKLEKFQLGFDGKWSMSESHLTVMNSFKMKTAIIVGVIQMVFGILLKGWNCLNQRKFIDFIFNFIPELAFMLSTFGYMSFLIILKWLTNYSNNMEPPSIITTLLNMVFTQGGITGAEMYPHQVYFQTILIRIAICSPIIMLLKPEVIRIKRSLFNIELEHAQVEVIKEEKNQMFGNLVGSRAIKEEKHFDFAEIYIESLIECIEFVLGAVSNTASYLRLWALSLAHSQLSEVFFKMSLEPQLESGSVIGICLTFMVYALATFGVLMCMDTLECFLHSLRLHWVEFQSKFYKGDGHNFQQFNYLHFLEQKFQFSTRM
The following text describes a protein:
Function:
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MRPPTTIYKPGLSNALKVSSKPAISVPAITSRNLHLARPAFSSIPLRATVSKSAHVTFKRSHSHHAPQPTEPIPEISSENTYDIVIIGGANAGLAFACALLSQPTISQTCRILLVEGSSLDRTRNWPESSEWENRISSLTHENIEWLESIGVWRHITNDRSCPVHEIIVWSNPSPTETPTIHFPPVGRPLARMTENLNLQKALLRRIEEAGKGIVDIRENSRVREMRLGEGGRWVGLRIGDEWVRGSLVVGADGPNSPVRHFSEIESYGHGYNTHAVVATLNHDPDPLYPNTTAFQRFLSTGPIAFLPLSDTSSTMVWSTLPENAAALKKLSHDALTQMVNAAFTLPEETLSSLCEAMLSAQSEGTPLTAPQIVTLIATLPTPLTSSDQPIIPPAITSIHPPSVASFPLRISHATSYLGERTALVGDAAHTIHPLAGQGLNMGLADVKCLAEVLEETRRLGGDLGSLEGTKGYPKERYPLNHLMLSATDKLHYIFRARNGLVNWVRGTGFDVINELGPIKRILMGGAGSGVGLGGASARTEKEREFGRARAEDKLKPAGGWPMAVANGVEGWFALKGVMGMVGGVVGEAARNGLRRAADALDGKR
The following text describes a protein:
Function:
Plays a role in synthesis, processing and/or stability of 23S rRNA.
Sequence:
MLNGPIPPHIDPRKLVDRGATLEGVYALADMPRVCEQLTSDAGEVRVKVSFERDHQKLAVMHMQLDTEVSMVCQRCLDAAAIPVHGEYTYAILREGQSADGLPKGYDALEVGEEPLDLLALVEDELLLALPIVPAHDPEVCQHPAGFVVEDEPESSEVEDKRPNPFSVLAQLKRDPNV
The following text describes a protein:
Function:
Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (By similarity). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (By similarity).
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Sequence:
MAPPRCPAGLALLLLLLGACGFFQSYAVEVDVKDASNFTCLYAQWMMKFLIKYETNSSDYKNASLDLTSTVTHNGSICGSDTQAALLAVQFGDGHSWSINFTKNNETYRAEFITFTYNTNDTAVFPDARRQGPVTIVVKDAMHPIQLNNVFVCHHTTSLEAENVTQIFWNVTMQPFVQNGTISKKESRCYADTPTAAPTVLPTVANVTTASTTISPAPTTAPKPAENPVTGNYSLKTGNKTCLLATVGLQLNISQDKPLLINIDPKTTHADGTCGNTSATLKLNDGNRTLIDFTFIVNASASVQKFYLREVNVTLLNYQNGSVILSADNNNLSKWDASLGNSYMCRKEQTLEINENLQVHTFNLWVQPFLVKENKFSIAEECFADSDLNFLIPVAVGMALGFLIILVFISYIIGRRKSRTGYQSV
The following text describes a protein:
Function:
Involved in chromosome segregation during sporulation.
Sequence:
MSDHNVNSTFRKTLVELCETATWITSQVYAAKNLEKNDLITVDNKISALYPIAEKYDRSFRTTTVILDEELILKLENAASSLWNSLTIAMKAEKASDKYFNEVFCKCKIFATKLLSIHEALFRTNTNLLRNFKCYISSFKSASEYRFDDLITNTQQHSEKYLQIINENVESFSNEEKTEFKKLTFEFYLVNFQLYLSENDLDTANIYTAKVNITDNSKYMDADLLIELCRMIYNSTVMLKEINNPETQLVDVNIISFLKDVEKYLELPVENLKSHTDYSNLKYSVLIFMANCLVEGHPQASELEQCDHYLSLLQNEYPNKVDPFILAINLTKRRNIVNPAETIEEILMRMIMSVDVISNFQAVIASINDLSKMNTKFSIVCLDYLLINKLNSKNDSKFLGKAICSRFLITTQSKTMNDSEIAESLENFSTQMERIVSEPLTKHAISCIITLLWNTGKKLEKMEKYVVSIRFYKLALKDIISQNYSDRGKIQRALQVVYNKIEDYSNTVRVYQDMDEVDRQSPLCQLLMLQSFLADDKTEEALTCLQKIKSSEDEKSTDALILAVAECKRKTDLSVQGLLMIFDKLQSKSNSQTISSTSSSQTLSILRYTLQMIVKVSEEEPLETFINYLPTVQKLLQKAVEFLKTVKLLNQLPPDVEKEAIYQQSVAVNEIEWFASFSYNVAVKCLVDQSCESISEFPQYCIQFIDLIPVQDFTFPKMYHFTYWRFKATILQLIIAKEKAKQDQHQKDWDIYEKSEELVNSINVMKKSSEFKDGSSLEDRNTLHECFLEALTIHLESALMMPDQTRILDILKKTELYQDSRVDALLIDISSNMEDLPKGVLIEILETVLKRNMGPEVKERELCSWLRILLENAINLNHEVELRILDRVLKILNINQSSLQDTDGVLQTELETIATYCWNIGVNYIIKDNKSNGIVWCKHSMGFANMVNEGLQEQLYSLWESLASSANIDINSIAK
The following text describes a protein:
Function:
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.
Subcellular Localization:
Cytoplasm.
Sequence:
MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPRAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCVICTYILLLTECLFFMKESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDGNEISTGNMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPESSEESQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNSTAEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASSTESACTRRVLPMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLADMPIRSDWHELPSQECSEHRESEGLITSGNDKHDAGVSHTAACSPTFSDKKEEITESLTEVTDIGFGNRCGKPKGPRDPPSEWT
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
AYASRGMTIIVTCIFIAISAILFQFIYEAQPTAFIDEIFHVPQAQKFCDGHFNEWDPKITTLPGMYIMSVFVLGPLTWLTGKGLCSLWVLRFFNVIYNTCNVLLCYLILKKLREKEKDNKEIEEDSIQWASLAIGFFPLLYFYSFLYYTEPGSTTVVLLAYLACINDYHRTAGVLGVVSILFRQTNIMWVVFMAGITVSEKLDDIDAVEKIQASPELKDKLARFFAKLLAAVVRYLLAVDHLLTIFNLIWPYLLVLCGFGGFVYLNQGLVVGDRSSHQAVLHLAQLLYFSGFTLVFSFPILVTKDKITSFWQMVQQRRNECLVSAAICCYILFSYSHEHPYLLADNRHYVFYVWRWFLGRTALRYFAVPVYMYSAWSINDSLSKKCTSLWKLVYFICVACLTAPQKLLEFRYFILPFVLFRLNVVQQTRTIIFLELLIYAVINALTVAIFLQKTFTWSDISEPQRIIW
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MWKFFITLGVIFSICSAQLLDTVSFDSNWENLHYIRNVDLNKGFVKETDLIEIKNINSKPQDEYYFTINDGFDSVNELSVFSAFLNDNLLEVKVDEIVANKVFKLKLPVPIAPNSNVELKINYVYIDTLVPIPTKISMDAVQQLLFKTNKFPYSPYLTKEYTLSLTGMSKGQEMQLHIDVNATEGTPDLKPRVDNQTLKYGPIAEDIQAFTLSPMGLLYDHNRPVTKAVNLNRSIWLPASDVNKVSIEEYYELTHVGAALDSGFSRIDWMKGRYEGTRNHWALSHLELPLLDRDLDGYYYTDKVGVVSSHKVVKNHLLLSPRYPLFGGWNYNFTFGWSEDLSRFLHKLHDTSDEYIIKFPILNSLRDVTYGDVYLEFYLPENAEFQNVSSPIPFESITIDNELSYLDVSKGHTKVTVHYKNLFDDLHKLDVFVKYKYTKINFVYKIVRISGFVFIGLISYYLLGLLDLSI
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Subcellular Localization:
Nucleus.
Sequence:
MNPPLSTGALLHVAATSSGPDAKVPITGVFQVLDIKQIQSKDNAANAKPRHKARMSDGQYTLICMLSSQVGDLVLSGALVQGAIVQITDFIINQVNDRKMFIAFNCSVLEQYGTYQAPIMVPPHTELVDAQKAAEEGNHGNQQQPPGGFGGNAGGYGGPPPPVNNGNGMYGGPPPQASASGYVPPGAAGGMYGGPPPPMNNAGPYGGPPPPQGGGMYGAPPPVKPDQQQGGGAGGMYGGPPPGQNNPYGAPPPQQQGYNPYAPNGGAPGGGGRPPANYQANGAIARDDAPPRFIPISALNPYTARWAIRARVTSKGELRRWTNVRGEGKVFSFDLLDKDGGEIRATAFGAEADKFFEVVEAGAIYQISKASLTNKRPQFNHTNHQYEIKLDRNSMVERVAEDPETSQIPTISYNFRRITDLETAEAGTVVDIIGVVETCEPWQTITRRTGEETQKRSMVVRDDSGRSIEVTLWGALVNNPGDQIEQMVRGGGRPVLAAKALRVGDYNGKTLSTVGASALRLDPMDLPAAQRVRGWYNGGGKAQAVNSLSAAGGGGGGGRTDRRTVLSAIKDENLGRSGKADWVNVSAVLDMIKTDNQGGASAVVYPSCPHDFNGRPCQKKMMDVGGGNWNCDRCQFSTENPAWRYLVSLSACDHTAKQSLTAFGDAGDAIFGRSATEVRNMEVDRPQEFDRLAESIRFTPFFFRLKVAEDNYNDEQRIKVSIYKMERTTDFVKECGAMLQSIKALEAGQNPFSNAAAAQTAGGPGGAAAPAGGAGPSGYGGGGAGPSHYGGAAGGGGGYGAPPPQSTNPYAAPSTNPYGAPPSAGGGRGPNTPPPAGNGYGAPPQGGAAGGYNQHQQGGGGYNQQGGGYNQHQQGGGGYGGPPQQPGGGGYNQQGGGGYGGYQGGGGGGGWNGGPPQQQQGGGGGGMYGGPPPQQQQQQQQAHAVPPNAFW
The following text describes a protein:
Function:
Plays a role in the inhibition of the host innate immune response. Mechanistically, promotes the autophagy-mediated lysosomal degradation of host TBK1 and affects IRF3 nuclear translocation to block type I IFN production.
Subcellular Localization:
Virion. Host cytoplasm.
Sequence:
MEAVLTKLDQEEKKALQNFHRCAWEETKNIINDFLEIPEERCTYKFNSYTKKMELLFTPEFHTAWHEVPECREFILNFLRLISGHRVVLKGPTFVFTKETKNLGIPSTINVDFQANIENMDDLQKGNLIGKMNIKEG
The following text describes a protein:
Function:
Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Accumulates around the actin complex before the formation of microfilament bundles and microtubule extension.
Sequence:
MPFNGEKQCVSEDQQSDSESSRFAEGVASLSDYECSRQSFTSDSSSKSSSPASTSPPRGLMFDDVMAAAKNLSDMTLAHEIAVNENFQLKQNALPENSLAGQVKRVVHQAFWDVLEADLSAEPPQYEYAIKLFEEIREILLSFLTPGGNRLHSQICEVLDIDLIRQQAEHSAVDIQGLANYVITTMGKICAPVRDEDIRELKATTNIVEMLRQIFRVLDLMRMDMMNFVIRNIRPHIQHHLVEYERNKFQEVVEETPNALSQTTEWLKESIDKELLSETDVAPAAEHSSTPSLSPLLVLNNCYLKLLQWDYQKKVLPETLMTDGPRLQELSEKLNQLKMTACVALITNNMVGAVTEGLPELANRLKRISAVLLEGMNKETFNLKEALHSIGVQTCAEVNKALEERGSPTLNAEVQANLVGQLSSLEEKDNPVCTLMDKRIQLYMKGLLCLPSTQKSMPPVPGGLDVIQRELEVLGCQYANIVNLNKQVYGPFYANIFRKLLFRDEAVGKIDASLPTN
The following text describes a protein:
Function:
Receptor for the peptide pheromone M-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; M-factor signaling alone may be sufficient.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLPIGIFYQFYAYFALVLSIPILYMQLRARNIPCLLLLFWLTLTTLIYVVESAIWSNPYAETIRWMGYGLCDITSRIVTCSSIGIPASAFTLVLYLDTVIRRDHPLKRYENWIWHVCLSILLPLIIMAMMVPLESNRYVVICMNGCYSSFYQTWYTLLFFYIPPCLLSFGGLFFVSRIVVLYWRRQRELQQFFQRDSQLTSKRFLRLLCLAAVFFLGYFPLTIFMVVANGKLQQFLPFNHELVEAWHQESITYYPTTKVGLNDWVPPTVLYLMSLFFSTSGGWTEKVALILWSLLVWLPFTKNTALGRHAQFKLDCCKSIESTMAGKTLDSTDFKEKCLVLERQWSKSSIPSDNSSELQDAAKYV
The following text describes a protein:
Function:
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors.
Subcellular Localization:
Secreted.
Sequence:
MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAANS