lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSGVRGLSRLPSARRLALAKAWPTVLQTGTRGVHFTRASAEVSDSVSSYFCSVVDHEFDAVMVGARRAGLRAAFGLSEAEFDTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYVTEQAPTAMVEVENYGMPFSRTEDGKIYQRAFGRQSLKFGKGGQAHRCCCVADRTGHSILHTSYGRVRPPYKLPLRQCVINVWFFAGTYGAGCLITEGCCGEGGILINSQGERFMERYAPIAKDLASRDVVSRWMTLEIREGRGCGPEKDHVYLQLHHLPPEQLAMPLPGISETAMIFAGVDVTKEPIPVLPTVHYNMDGIPTSYEGQVLRHGNGQDQIVPGLYACGEAACALAHGVNRLGANSLLDLACALSIAESCRPGDKVPPIKPNAGEESVTNLDKLRFSTQNHAAVFRVGSLLQEGCGKIKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTVSGAEAWKESRGAHAREDYKVRIDEYDHSKPIQGQQKKPFEEHWRKHTLSYVDVSTGKVTLEYRPIIDKTLNEADCATVPPAIRSY
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MPSQAPGPDVLENPADLLRQTRENFSIAHDLQLLNATEENLRRLMQRTQQLEAKGAQELSELQAQQTERAQAAEAMRAEKETQAQHLQALTHSQDLVRLANELEELEQQLVSLRAELDEGMTQLLQTSEPTAAFQGDAEHEQQSPEVQTNLLKLQLYSSLGVTLDTEHNQALIERGDAAGIDLIALEDDSLSPFFRTKYVWDRL
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASALEQFVNSVRQLSSQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGICVIRQAIDKMQMNANQLTSIHGDLCQLSLLAKCFKPALAYLDVDMMDICKENGAYDAKPFLCYYYYGGMIYTGLKNFERAMYFYEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQLPKYTSQVVGRFIKPLSNAYHELAQVYSTNNPAELRNLVSKHNETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGAQEAEKYVLYMIEDGEIFASINQKDGMVCFHDSPEKYNNPAMLHNIDQEMLRCIDLDDRLKAMDQEITVNPQFVQKSMGSQEDDSGSKPSSYS
The following text describes a protein:
Function:
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization:
Cell junction, desmosome. Cell membrane; Single-pass type I membrane protein.
Sequence:
MDWHPYRTAAVLFIFMVSLEFCIGRFYVEVKEWDKNGVERLKTYRRQKREWIKFAAACREEEDNSKRNPIARIRSDCEETQPIIYRISGVGIDQHPFGVFVINQKTGEINITKIVDRETNPIFTINCHAINPITEQSVETPLELRVRVLDINDNAPVFTLATFSGSIVESSMENTLVMKITATDADEPNNLNSKIAYKILSQTPGGPSKFILNAANGELHIANILDREEAGQYSLVVQATDRDGGPDGISSECLCQVSVDDVNDNFPVLSQSSYSVSIIENSLSQDLLRIQVEDADLAMTDNWFAEFFFISGNENNNFEIVLDQATNEGILRVVKEIDYEQFSSIPLSIGVRNIAPFHYSVASQYQAHGTPIIVQVNNVIEGPSFNPTTITVSASEGLTSENILTYTVGKFEAIDQDTGRIATNVRYEMGHDPAAWFNINPTTAEITFSKVIDRESIYVINGAYRAEVLAICKDAPYKTATGTIVLTIQDVNDNCPVVTDEIRKVCMDNPSVAITAKDLDDHPYGPPFRFTIVAQSPGSSWTIRIINETSAALFSNDVGFFIHEVQVKVYDNSGRSCERPLVVPLQACHCDRNAMCINGATQRIRVTIVGGGAGGGGMGGGGGAGGGGMGGGGAGGGGMGGGGGAGGGGMSGGGGAGGGGAGGGGAGGWDMGGGGGAGGGGMGGGGGTGGGGMGGGGGAGGGGMGGGGGAGGGGAGGGGWDNYDNGAGGGGDIDSGRITDGGGYDSGDTYVPGVGVEREGGGFALSPAAIFLMFLGGLIFVLVPILMSQSNCCRYCKSRPVGGVGAGFEPVPECTEGAIHSWGIEGAQPEDRDVSNICVTGTTKGDFGDSSDIYTTKYDGGMVSREETTGLGTVKGYGPTVGYETTTGYGTTGRTKETFGGTIKEYRESGVNMAFLDSYFSEKAFAYADEDEGRPANDCLLIYDHEGIGTPVGSIGCCSFIGDDLDDTYLDTLGPKFKTLAEICLGIEIEPFPDPNAPWPSLPNPEIELNLPPPGTTIVVNTSPPVPPPTNIGSTTVVTENTYTTSSVQPPRPMPDPMLHGNVVVTETYTSVPKLKPPTLNIDSLHGSNVVVTERVLAPGPVTDLHGMIDIPELPDGSNVVVTERVIAPNARIPPSMSIPDMADGSNVVVTERVIRPAASMQGNLGIPPELAGAHNVVVTERVVSGAGMSGGVGNMSMMSGAGMSGVGGLGPMLGPDNLLSQTMGSASPATSRRRVTKYSTIQYSNQ
The following text describes a protein:
Function:
Endonuclease which, in association with baf-1, plays an essential role during embryogenesis in the DNA repair response following DNA damage probably by ensuring proper chromosome segregation. Also required during postembryonic cell divisions after DNA damage caused by ionizing radiation to ensure normal cell proliferation. Resolves chromatin bridges in late mitosis that result from incomplete DNA replication, defective chromosome condensation or unresolved recombination intermediates. Together with brc-1, contributes to genome integrity by resolving mitotic chromatin bridges that result from incomplete processing of DNA breaks. In parallel to the slx-1/mus-81 pathway, acts in processing early recombination intermediates in meiotic prophase I to prevent illegitimate recombination. Also involved in processing remaining, erroneous recombination intermediates that persist into the second meiotic division.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Midbody. Cytoplasm, cytoskeleton, spindle. Note=Localizes to foci-like structures outside the nucleus. In pachytene, localizes to foci both in and outside of the nucleus. Colocalizes with air-2 between dividing nuclei in meiosis II. In mitosis, localizes to the center of chromatin bridges that are formed in response to DNA defects. Forms initially a ring like structure encircling chromatin bridges between two separated daughter cells until in late telophase, localizes to the center of chromatin bridges. Colocalizes with air-2 at the midbody. Midbody localization depends on the formation of the central spindle and the midbody and on air-2. Colocalizes with the central spindle component zen-4 at the central spindle.
Sequence:
MPPNGAITTTPRSRMPPTTPSSGKSRPKKETLHYLAASSSTTSVDAARTLLERGANVNAIDRDGATPLHYACTHDNVAMAQLLLTFGADPMSADKLGRTAYSIAKGNTLRFLRRYKKSSNRQRLGFFRRFFACHSRNETFFIVRNNQEVAPLRPTALAEAASISFNRGNVLTNSYRCAKKKIRATFHAIRRSRSNSTATLQDVVLTSEGIRTVTTPSRRAPKATVYAKRSMSVSDLLLIPDRRDIKNEDVKTRGSPVKKTRGTGRSRTPEAILNPRKQRTPVNHHKRSKSQETKLVAMPSPNSMAYYNTSRARNAGLRPAPSAPPLSPEPAIAAVKTPKTPTTPKTSKGRSKSPANTTAYFTADESLELLGNNMEKLNIESKSAKSSKLKTPSKPTTSSSTSFSSAEDDKEAEVSTPTTVDDGEIRKIRRLREGELKSELKKFGISPAGPLDARTRRLYEKKLLIERRKITNRGYSPDADVVSCRNSPQLELVLRNGFLPADFASRARKCDENVRSEFSGNGFGYNAFCYLIMDPRILGSNVENLTLETFVRSIFYVGKGSKNRPLAHFIDARNERRDKLDKLKTCEKLKTIDELWTLGFGIPRHEISHGVSDEEAFVREASIIEAVKLKNLRNKKAGEFHGTTKSWDNITKSEYGTFLLDRALSTLKLEGIRLITEDNLPDSLYPYVNNRRGAGGGRTPKTPK
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLNIGDSVQIPGCSTKKRLLETTSGCDSFDTLLGGALVNSSIVLIDEYRSRCYGSYLVRSFLAEGLHYGHRCFVADPSEDVSETILKVIPTRKAAEDDQKKEIPSSPGQADNDMKIAWRYGNVKQVTSEIGPSGNQYDFSKHLENSNVDVYNEEIPSFSGLYKILCEVVQKEEAHTKSTGRGGPKKNLLRVVLKNIHLNIWEDYESLGRFLCCLRSLARSSYAVIYIVANSHRMPNDTWRQLESAADTHIQLMPFNEQEKKMFRHLGTAHGYFHLKSLPRLMSAGTHTPPILDLIFEASSKKGFQIRVMHLPPAFDEPAPGQQKATACQNIDF
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MKNFFILHLRNNYSIFLNKPLQVFTLNVKLNSHVKVNYKHELLTYEFRKITYVKKKKKKSYHNCDGRYITTLNKTININEKYSKLKNDGLLNSTPDNHIKDNIIKEDLLYRKNNEKENEEVIKSNIDENKNVHMNDQNEQNKHCYNKLLIESCCHIDKDVKKSLLEIFQYKEFTDVQRIVYDNIIKEKKQNDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHTLIIVPTRELANQIYNECKLLLTYKHNINVLTLTGGIKRRDDQLNIRRIKPDIIICTVGRLLDHFESTYLFNTLFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIRKKMCKSDYIYLNCVKDISKHTSDQLIQYVLFHKAIDTTIILYNLLIEHMRLNQFTYKIIVFFPTARATSFYAQFFINQLKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRVGRTARSNKKGMAIILLNEADELFYQEIKDLNIQKLNAQNYTLKNTNLSNYLSTWMSNTQLLYLAYAYYSSILRFYKTKYTHLKINDDEIIDAVNNMLLSTGLVEQPYISRNLATTLNMQNNVKLKIRKDLDDILLL
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm. Dynein axonemal particle. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.
Sequence:
MLLWLPTTLHVSVWSLPSKVQNQGLLTKVTMEVGKKLELSITADEVEVLSKAIKNEKFQEMLSNYFQEISSPENVKTYQEEVTLLEQKRGNSIEFIHPSPFRALETSVDGKQRCFINICACDKVGKPESKTVRTVQRFGEKWSLPHLLQPGRQNCERKGNISTIYDVCFHPETLHLADKSEKFMDMVKEVAIQGIQKAFKVLLDKSNLKEMDIKYKGVPQSCVIRKPIPGYEAKEPPEERDLSPSTSHLPENSIDVPSKLLQKQPEEPIKPIYAIKYRSVIDLQDFRVSRESARSLRPKEIVITIDLPLLPTVHGMVLEVEEKRLLLESENPSYRLELHLSYPVDENNGKAKFNKHQRQLTVTLPVQPPLEAPQLPGGSPNPTSDPQNENQTRVEERVEEMAEKGGEQRQRGNDNGAAQGRRQVLEDQNGEKEGKKIQKRNERPEHEVKNETLRKKHDEKFELQDVQQENKGNCSNTKEVKCCRRTKDSLDSLIPTTAASPDGQKKHILTQETEKPKGSVEIPTSSQEYLKVPVTSAATAANVNASDETSKRKPTEEQLEDADEDVLPAEQRFQEPEEINVPAAGTLRQNNAAGNEKINDPHTSAGFVLQNKLMYELD
The following text describes a protein:
Function:
Involved in the biosynthesis of the lanaridin cypemycin. The enzyme can methylate a variety of oligopeptides, cyclic peptides and the epsilon-amino group of lysine.
Sequence:
MSDPSVYDETAIEAYDLVSSMLSPGAGLVAWVSSHRPLDGRTVLDLGCGTGVSSFALAEAGARVVAVDASRPSLDMLEKKRLDRDVEAVEGDFRDLTFDSTFDVVTMSRNTFFLAQEQEEKIALLRGIARHLKPGGAAFLDCTDPAEFQRAGGDARSVTYPLGRDRMVTVTQTADRAGQQILSIFLVQGATTLTAFHEQATWATLAEIRLMARIAGLEVTGVDGSYAGEPYTARSREMLVVLERQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAAGRRLLGKKDYDERRMEEEEKRLSTERRQRETPSSIYAHKSVQETLDIFATHPTDGLANSAVAPLLARYGPNEFEVPPSDPLYLKFAKQVYENPLILLLLGSSVVSALMGQFDDAACVVIAVGIVLTVGFVQEQRSEKSLEALNKLVPHYCHLIRNGTPLSPLANALLPGDLVTFSVGDRIPADIRLITANHLEIDESALTGETRPARKNTQLCERGEGEDTHGEGGGKALGERHCMAFMGTLVRSGNGSGIVVGTGKDTEFGVIFSMMQDVEEKRTPLQLDMDNLAKQLSIVSFIVIGFIVLIGVIQKRDWLEMFTIGVSLAVAAIPEGLPIVTTVTLALGVLRMSKRKAIVKKLPSVEALGSVSVICSDKTGTLTKNEMTVTHMYSVDELVDLTPHLNVTSPFGPRRPDSQQLWISPALLKVALVGNLCNDAFKNEQGINVGQATEVALLNVLPVLKAEDQRKNFIRKSEIPFSSETKTMSITGSLNNSPDMIYLKGAVEQVIARCRYYYVTDSSTPSLDTATQKIILDRAMEVSKRGLRVIAMAYGFPGKGDDEPNNLVFVGFEAMMDPPRNGVVHAVSALHSAGVQIVMITGDAEPTAVAIAKQLGLKVSASTSGTLDDHPHSLFSGSSCILGSQIDQMTERELVERVSSITVYARTTPRHKMAIVKAWQMRGAVVAMTGDGVNDSPALKMADIGISMGKSGTDVAKEAADVILVDDDFASILPAVEEGKSIFYNIQNFLSFQLSTAVAALSLITLSTVFKLANPLNAMQILFINILMDGPPAQALGVDPVDEEIMRQPPRKKGSHVLSTRLIYRVLFSAAMIVLGTLWIYTVETSDGSMSRRDQTMTFTVFVFLDLVSALQNRGLTTPMFRNRMLFLTISVSFICQLALIYIPLLQHVFQTEALSARDLFMLLGLAGTSMGLHEGRRWWERKQVEAEILEKSAGGMV
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MMEEYLGVFVDETKEYLQNLNDTLLELEKNPEDMELINEAFRALHTLKGMAGTMGFSSMAKLCHTLENILDKARNSEIKITSDLLDKIFAGVDMITRMVDKIVSEGSDDIGENIDVFSDTIKSFASSGKEKPSEIKNETETKGEEEHKGESTSNEEVVVLPEEVAHVLQEARNKGFKTFYIKVILKEGTQLKSARIYLVFHKLEELKCEVVRTIPSVEEIEEEKFENEVELFVISPVDLEKLSEALSSIADIERVIIKEVTAVTEESGAEKRTEKEEKTEKTEEKAERKKVISQTVRVDIEKLDNLMDLMGELVIARSRILETLKKYNIKELDESLSHLSRITLDLQNVVMKIRMVPISFVFNRFPRMVRDLAKKMNKEVNFIMRGEDTELDRTFVEEIGEPLLHLLRNAIDHGIEPKEERIAKGKPPIGTLILSARHEGNNVVIEVEDDGRGIDKEKIIRKAIEKGLIDESKAATLSDQEILNFLFVPGFSTKEKVSEVSGRGVGMDVVKNVVESLNGSISIESEKDKGTKVTIRLPLTLAIIQALLVKVNNLVYAIPIANIDTILSISKEDIQRVQDRDVIVIRGEVIPVYRLWEVLQIEHKEELEEMEAVIVRVGNRKYGIVVDDLLGQDDIVIKSLGKVFSEVKEFSGAAILGDGSIALIINVSGIV
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MELFKIKRDIPFMSYGKLTTFISLVTFIAAVFFLVTRGLNFSVEFTGGTVMEVQYQQGADVNKMRERLDTLKIGDVQVQALGTNKHIMIRLPNKEGVTSAQLSNQVMDLLKKDSPDVTLRQVEFIGPQVGEELVSNGLMALGFVVIGIIIYLSMRFEWRFAVSAIIANMHDIVIILGCFAFFQWEFSLTVLAGILAVLGYSVNESVVVFDRIRENFRKPAMRGHAVPEVIDNAITATMSRTIITHGSTEAMVVSMLVFGGAALHGFSMALTIGIVFGIYSSVLVASPLLLMFGLSRDNIGKEPKKKEEIVV
The following text describes a protein:
Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Subcellular Localization:
Secreted, extracellular space, surface film.
Sequence:
MASKWGGWVLILSVCLGYYQAGASPLPECGEQPEDWCRDVGTAAKCGVLELCRLTLWDQAIGQKGIPCHLCQVVVSMMGKILQDNCTEEKLRLFLDKRCQYLPFQDWSVKCKKMVDTGVLILAQLGKQVLSDPKVVCGTIKLCQPRVGREGALKFQEQPSTPADPAQDLAQLSVPFINGVPLLLQPQDLPHSQDSGDLCEDCARLVAAVQLELSNGATTARSLVARAKEECEGLGPVLAQRCNYYLAKYADTATWMLRHLLAEDPRELCGMLELCPTAEPGPLHTLLSEKMAQLLGTLFSNTEATPLCEMCEFAVRTAESLLENNMTEEQLVNDIEKVCYMLPHSVIGQCKDFVDSYGKAVVIMLLEATDPQAVCTMLHICPHWGVAQGAELRAALEPAAGAFCNVCQILISYLDNELLKNETLTELGDVLEKACELLPGPLTSTCEALVVQYEPAAVRLLVQMMDPDFVCTKIRACDSELTSVPCAQGPDYWCISMATATKCDAVEHCRQHVWN
The following text describes a protein:
Function:
Involved in degradation or processing of the mating pheromones. Its loss may cause a persistent response to the pheromones. It may cleave the mating pheromone M-factor. May be involved in processing of zymogens that are required for zygote formation.
Sequence:
MKASFFVFAISALQALQASVASAYSEVPGKRSVVLNLQHSQYDHVARKLERTKVLNKRDSSGYPVLDLEYTDAGGYFANLTLGSNERVYSLTLDTGSPYTWVTAKNITALSASEIWSDTDGVDAGRSTSDIRTNACTNYTCFDYSSTTARRTNSSTIGFLASYGDNTTVLGYNMVDNAYFAGLTLPGFEFGLATREYDSSQISVTPGIIGLSVAMTITGISSDDKVVAFTPPTIVDQLVSANVIDTPAFGIYLNEDVGELIFGGYDKAKINGSVHWVNISSSDDSTFYSVNLESITVTNSTSSNNVQSSKRSSKDIEVNTTVTLDTGTVYIYLPEDTVESIADQYQGIVSEYGYVVIYCDSFSDSDYISFNFGSDADFHVSVNDLVIYRQESTSGDICYLALFEGDTSSYLLGQYFLQYVYSIYDWDAQKIGLAALNSNATSTANHQILNINSALRSVTSGQSVSATPTVSMSIAATSFGSSLVLTASASPSSTSVDGSSSSDSSEASGAASVGVSISAIVLCASTLISLLFA
The following text describes a protein:
Function:
Self-incompatibility (SI) is the inherited ability of a flowering plant to prevent self-fertilization by discriminating between self and non-self pollen during pollination. In many species, self-incompatibility is controlled by the single, multiallelic locus S.
Sequence:
MKFLETIVFMVLGIALSFNIGGNMSCNAPGQYDYFQFVQESPFLFCKNINGKGCNILPLPRIFTIHGLWPSNFTHRHKPCVGAQFSRDINEASNDELRADLELSWRSFISGRSNMDFWEYEYNKHGKCSDDKFSQTQYFDRARSLWKQYKPHALFSNRSLEPGKSYSFTGLEQAIRSFIGGSRPLLLCEQSKRKKNKKKTK
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
Subcellular Localization:
Secreted.
Sequence:
MARRGCGATSCYTTKTKLNSFYSFLCAFITCVSLCPVLCEAGLYTASDQVIVLTPENVDSTLFNNTAALLVEFYATWCGHCIAFSPVWKSLARDIKEWKPAVDLAAIDCANESNRKVCTNFGITGYPSIKFFHAYSSIGSRGLEVRGFSRDVRGLRQYIIENLELHTEAWPPACPPLETASEAEVHHFFPANNVKYLALVFENKKSYVGREVTLDLLQYENIAVRRVLDTETNLVSRFGVTEFPSCYLYDSSGNITRLKVLKEARTFYSYALQRLPGVVRTGKHQTPITELIKNSTLQEWRPFNKSRVYMSDLESALHYSLRVELSSHTSISGDDLIALKKYINVLAKYFPGRPSVKSALQAVDSWLQSQKGTEIKYSDFRDVLDNVVQTSDAVLPEGVQWVGCQGSQARYRGYPCAVWTLFHVLTVQAKEMGSTVSEPQEVLLAMRGYVSSFFGCRPCATHFEAMAAESMDQVNSLSGAVIWLWSRHNRVNNRLAGDLSEDPHFPKIQWPSPELCPSCHGVTIIGDHNWIKDEVPQFLQNYFSSSRILNDYLQDETQALIQQRNRLTAARMEKEAGRGADRRARDIFDNNPADEPQEEEEEEEEEEPTFEEQAVEPYPAGLEGAPGADQAPWEKPQPLSSQRKPKIVGMKLREAQEDIVDLDYFVSQHYKAKALRAAAMSGVVRRRSLQKKEDVEDLQFEGGWRVKRDLGSQEENFGIEPYPRAQSKHWMSLLSVGFSRLDVSLCVLLYLLSTMCLLAMYMYFKLRIKLRSAKVSLP
The following text describes a protein:
Function:
Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
Sequence:
MPPIPWRVQTTSHPGSTRDEIEQEPDWNAEHRHEHRIGYKNRYDRLPGVTHERDEHTQIDDVEQAREGYEKLIKEAKHGDLINFRDIVLNENDLHLRHPENRSLGWRFVLQCTEDWVKNKEDWPANIQKRKKEEEAKKKEDDEKGADSSTSKQDDGHLDEEKWKRENGEGSKHHDAYSGNADDSGYSSEESDKQKTGYEKLLERYTPQEIALLKALQHEKDYIHNLEQNDGKRKSPQTHNRSTISIDEADQFSPDNWLPRSSDLIRLTGKHPLNAEARLSPLFDAGLITPNELHYVRNHGAVPRILWEFHELDIEDGKLVLSMEDLKNNFEPINIAVALACDGNRRKELNMIKKSKGFSWGSGAISCAYWKGPLLRDVLLKAGIPHTMPRGKRYWVNFEGADEPSEGKYATCLPFDYAMDATNDVILAYEMNDVPLPPDHGYPVRLMIPGYVGGRCVKWLKRIWISEKENDSHYHIWDNRVLPAFVTEKDGEFAEALFRHPDTACNEQNLNSVIVKPAQGEKIPLSSARKGETYRIEGYAYDGGGHEVQRVEVSLDDGDTWLYCIRKFPDAPIRHGNKFWTWLHWHVDIEISHLLRAKTITVRCFNVFKNTQPKEPNWNVMGMMNNCWYIVRPEIIQDSDADTPSILFRHPVEPGTADGGWMKPSVENQIASAKQDAGAPQKQFTRQEIEKHDKEDDCWIVVDGKVYDATSVLEWHPGGKAAVLGHAGKVHAETSSEFESIHDGYAYQKLKECILGTVTDKAAAFIKTQAEAAAKEQAESSNDSGKIVLQTHRWVPVKLIDRKPLSDDTRAYTFELPDGKPDLGLGTCQHVQLGFHLQDRMLIRSYTPTKPLLPDSSNQTTNADDHGTHDGSGTFELTVKTYFPTDAQPGGAMSNILDCMPIGEEIEIRGPTGEIVYNGNGSFKISGKEYKFNKINLILGGSGITPGYSLIARALLSSDDETEIRVVDANKSEKDILLKDELDKFEKDSDGRLKITHVLSHPSNEWKGTKGHVNEDIIKESLFEPGEKTGVFLCGPPAMIQKSALPALRDWGFKEDENVFGF
The following text describes a protein:
Function:
Probable translation initiation factor.
Subcellular Localization:
Cytoplasm, P-body. Note=Localizes to P-bodies during response to heat stress.
Sequence:
MAPKKKGQKMALHEFFEEAATSGTSWADDDFDLPTAPAAREESGSGLKRGDPGYFESLPDRGSRQATFAGAPVQREELPLPTVPPFTAFIGNLSFEPDVEDEVRAFFNDLDPVSVRIVKDPQGKPKGFGYAEFKTQDGLKQALDRSMSQLQGRTIRVNVAEAPSTSRHPPSAAEEASQWRRSTPLASRESSSQPSRRTGGPSEPAADLDWSVARGAKFTPSAPAAPLSGVRRDSSGPGHTREPRDPGVSDTADQWRSNKPLAEKVDRDVPPHQAGVAPPIVSPSLADTEQTWSRGTKLRTPTTTSRQSSADSTPSSGAPQERRKLNLKPRTAGSPSATANATPAAPASGIFGAAKPIDSAAREKAAEEKLAQREGERRKAREEAEKQKAAAGDKPVEGEKLGWREEKLRSIKAAQDKVAGKPTTAPATTTNTGAGRKGSADRAKKDEQGFEQVQPSRKSSQTGATSENKPKKDYSTRPQFSFAAAAGAIRNDLVEDKDEEEVTKGVEEVKI
The following text describes a protein:
Function:
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm (By similarity). Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MTATRGFTLLEILLVLVLVSASAVAVIATFPVSVKDEAKISAQSFYQRLLLLNEEAILSGQDFGVRIDVDTRRLTFLQLTADKGWQKWQNDKMTNQTTLKEGLQLDFELGGGAWQKDDRLFNPGSLFDEEMFADEKKEQKQEPAPQLFVLSSGEVTPFTLSIFPKGQEPDEQWRVTAQENGTLRLLAPGESDEE
The following text describes a protein:
Function:
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Is involved in NF-kappa-B dependent negative regulation of inflammatory response.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.
Domain:
The N-terminal region is required for cytoplasmic localization; The ANK repeats and the SH3 domain are required for specific interactions with p53/TP53.
Sequence:
MDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGPQAGPPSRPPRYSSSSIPEPFGSRGSPRKAATDGADTPFGRSESAPTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATSPRPRAFDGAGSSLGRAPSPRPGPGPLRQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFPERGPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAWNESDLDVAYEKKPSQTASYERLDVFARPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLGSAGPSGTLPRSWQPVSRIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPTPAPQHPQQTWPPVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKAGSPRKARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCAASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAALHGQEGYVPRNYFGLFPRVKPQRSKV
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MSAAIIEVADLDVYYGTSQILFGVGLSVRQGETMALLGRNGAGKSTTMKAIMGLAPPRRGRVSLRGAVISGRKPHHIARAGLGFVPEDRQIFPEHTVEDNLVIGRKKGPEGQDEWPIKRIYEVFPLLEPLRHRIAGRLSGGEQQMLAIARTLMGNPALLLLDEPSEGLAPIIVQRIGELLRQLRQLGSTVLIAEQNMHFCLGLASHATVIDKGQIVYAAGIDELKANEAIRRRYLAL
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Sequence:
AFTPFFILFMMAVQCWRRYEECVNTSIFSHSTINLFHFMTGVFVYSTFPLSILTQAIAPENNSGSIAMQISCQHILGFLLFCIASFTQRSTHKTLAELRLDNKTGKVKDLNHHVPKGWMFKHVSCPHYLCEIFIYCSFCLVDSFGSEILNYIFLFVIVNQIVAAHMNHTWYKKTFKYYPKDRKAIIPFIF
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDVAAVITKENINNVNYRRLTKEAIGEGNERYEAKKERQRLIKTGKRPDLEDEEEEEMEEKRGKESEYDSDFASGSVCPFKLGPFPRKLLSTPIEELDPARQEDRSFVVVGRKFKTSQIFRFTTNDALYCLSPLNPLRRLMIKIYTNEFFDLFVILTIIANCVFLMLDTPRPPEVEEPTYLKIAEYIFTTIYSVEMFVKIFARGFALHPHTYMRDAWNWLDFFVIVLAYITFGLVESGVDIGNFNFLRTFRVLRALKTISVVPGLKSIINALIRSTKMLGEVMLLTVFALCIIALLALQLFMGKLTRKCVANIPPVDFNISDEYFFNFTQDPANWLTWNSDPVICSNMTLGGRDWSLCPENYTCLEGIGDNPNDGYTNFDNIGYSMLTCFQLITLDYWENVYNNILKAQGPYAVFFFLTTVMFGAFYLINLMLAVVSMAYTEEMENQGKEKAKKMKQKKDNVMHLDAKKLQKLAAKKKKKKQKKQAEQDGQEESQQGSQVPMLTNGKENAGYTGEGAAPGTAETNRQDDSISDVGSKISGKFAMKALLSTYNKPIGAGAVDADQDTEMNDGMTDINDAMTENIDSVSGIGSKNDSDSQAKQSTAGGDDDDEEAIPFNEDDPDNLKNYPCCDYNCCCGCCRRNFICTFPHYRRWRKVQYIASWVVLDPLMDLFITLCILGNTAFLMMDHEEISDSLAYISEEGNKVFTYIFTIECVLKLIALDKKFFKNPWNVFDLFVVCVSLLEFGLANVEGLSVLRSFRLLRVLKLAQSWTTMRTLLSIIASAITAIGNVMIVLLIVMFIFAVIGMQILGGSYTPENFGVATFEEIPPWTFQDFQHSIMLIFRILCGEWIEPLYDCMNVGNKPFCVILFIATLIVGNIMMLNLFLALLLNSFASDSLQNKKAASESKLILAFRKIGRFLKCLVRPCLCCKKYKNKNKIGDSVENLKALANGNGTTKKNGVIPIENGHGGKATIHEFIVVEDVGNNEDKISTIDIDNGSQTVIRHRNQLTTNGYHLHPALASSNGNLPVMYTNGGSYHGSAVSLRSLPNRPHVAFVTPAPVPAILPPPRVTPSLRLDPADARENDSLADDAGNCPLVIRTNAETGEFEPPRSVAATPIAGRSVSHASLHSIASRRDTAVIVQTTATMEEPILEDPVKDCLPRLCASFYAKKCSCIPCCLDANESNWAYRWRRYREIMFTVCEHKVFETFIIVVIFGSSFTLIFEDIYLDLHPRRQEILKILNYVFFGIFVVEMLIKWSGYGFVKYFTSFWCWLDFCIVLVGLLSLLGDVIGLTNFAAFRALRTLRALRPLRAISRWEGMKIVVNAVVHAIPSIANVLLVCAMIWLIFSIMGVLFFKGVFDRCVDEFGDRLLHTIVNNKSECLEKNYSWETPPINFNNVGLGYVALFQVTTFEGWMEAMAAAVDSRGSREENLQPIKDNRFYYYVYFVILIVFGSFFLLNLFIGVIIDNFNALKRKYEGDSSMDMLLSTSQKQYYQTMRRMGVKKPTKQIKQPTAGNKIQNFFYRLTTSNKFELVIVTVIVMNMILMMIDHYGMSQELTDITAKFNIVFTSIFVCEAVLKLIGYSWYYFKIPWNVFDIIVVIFSVLGIVLDDVLNSVFINPTLLRVLRLFRIGRVLRLVKQAKGIRKLLFALVISLPALLNIGILLLLVIFVFSIIGMSQFGHIKLDGALDKTTNFQTWVNSALLLFRLSTSAGWNDVLDPMMIQEPDCDPNFEGLPNGNCGGFYIPIFFSTVYLVITFLVVINTYIAVILENFSQAHAQEEVGITEDDFGMFYQIWEKYDPSASQFIKYEQLSEFCDALELPLRLARPNRIKIAALDMPIYDGFRLHCLDVLFALTKRVLADVEESEDFTELQKQMAEKFAESFPDREQNQPTTTTMKINKMSQAAKIVQRAYRFFRLRREISKAASANRASQASAANSRRNSVTHEPARLNLDVSHGSSLGPAMELPGQLGLSRSATPMIPEENLDNSATHNKAEKYQLEEQGSEIQTIDASVDIVGSQNTNEDSTTQV