lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for transcriptional regulation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) under stressed conditions, acting downstream of ire-1, and also maintaining ER homeostasis via a negative feedback loop, in parallel with ER kinase pek-1. May also regulate Golgi protein trafficking distal to the ER. Protects the host organism from the detrimental effects of mounting an innate immune response to microbes, such as the Gram-negative bacterium P.aeruginosa, probably by modulating the UPR; [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ire-1: upon ER stress, the emerging xbp-1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient ire-1-mediated xbp-1 mRNA isoform 2 production; [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE) (By similarity). Plays a role in modulation of the UPR, lipid metabolism, proteostasis, and lifespan. In neurons, rescues stress resistance, increases longevity, and, drives expression of lysosomal genes in the intestine and activates the UPR in distal, non-neuronal cell types through a cell-nonautonomous mechanism. In neurons or intestine, plays a role in protection against proteotoxicity, acting via positive modulation of genes involved in lysosomal function, including lipases and the fatty-acid desaturase fat-6. Protection against proteotoxicity in neurons is dependent upon the transcription factor atf-6.
Subcellular Localization:
Nucleus.
Sequence:
MSNYPKRIYVLPARHVAAPQPQRMAPKRALPTEQVVAQLLGDDMGPSGPRKRERLNHLSQEEKMDRRKLKNRVAAQNARDKKKERSAKIEDVMRDLVEENRRLRAENERLRRQNKNLMNQQNESVMYMEENNENLMNSNDACIYQNVVYEEEVVGEVAPVVVVGGEDRRAFESAAFINEPQQWEQARSTSINNNISNQLRRMDSKKNNTISVDMYLTIISILCNHMDRNKKMDTSNKSSNISRAQAESSIDSLLATLRKEQTVMQRLVQADPCTHLQKRVKHFRRIP
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Sequence:
MVDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITHMHGDHVVGLPGLLATIGNSGREEPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKESLNVNVLKNGMEVLKEYGSGNLIKNNSLKDCIKNGEDSINQYENYNDKLRYDIEISTLELDHSCPCIGYGFYINRKPKFNLEKAEGNNVPKFLWSRLQKGESLVYEGIKYNSSMVMGRGRKGIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGQDEDLHKAIKNKHMTFREGAKLANKGKVSQLILTHFSPAMIDPESFKQNAMEVFPDTLIGKDRLIKTLSFKE
The following text describes a protein:
Function:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Subcellular Localization:
Nucleus.
Sequence:
MKFNRLIFPKGEIVLDHVLQCGQAFRWIWNHEKRYYSASMLLNDKLGYRIIVLKQPDQCSIEFSVAGNKDDDCSGAARQWLMRYLRMEVNLEALLAEWQKADTRFIGKTHRGVRILRQEPWETLCSFICSSNNNIGRITKMCHALCSQYGSFLGELDGTPYYSFPTSKQLMEGASEDALRDLGFGYRAKYIMAAAEWMDSSKPAHMSDTEHLESWLDMISREEIRQRFMEVPGVGPKVADCVCLMGMQMDDHVPVDVHINRIAQRDYKFNASAAKIAALKARYKDLPSVRKKLNMELELVREMFIQKWGPYAGWAQGVLFAQEINKSDTATKQGPASNQEVAVAKRKVEEKDFLHEAGSEAAVVEVALDGVEFSASGRPLRTASKRIRYST
The following text describes a protein:
Function:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.
Subcellular Localization:
Mitochondrion.
Sequence:
MSGLVRRFYPFKINSVRNFLSRNYSKPVIKPLEHIKPELIITDTCVERLKNISKNSDEFLRVSVDGGGCSGFQYKFDLDSKINEDDKIFEKNGAKVVIDETSLDFVRGATVDYREELIKSSFRIVNNPLAEQGCSCGSSFAVRLD
The following text describes a protein:
Function:
Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site.
Subcellular Localization:
Nucleus, nucleolus. Nucleus speckle.
Sequence:
MAHVSSRKRSRSRSRSRGRRGSEKRSKRSSKDSSRNCSTSKSQGHKASSTSGVEERSKHKAQRTSRSSSSSSSSSSSSSSSSTSSSSSSDGRKKRGKHKDKKKRKKKKKRKKKMKRKGKEKAVVVHQAEALPGPSLDQWHRSAGEDNDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRLIKGDGEVLEEIVTKERHREINKQATRGDGLAFQMRAGLLP
The following text describes a protein:
Function:
Required for RPP13L4/ZAR1 recognition of the Pseudomonas syringae type III effector (T3E) HopF2a.
Sequence:
MESMVKKLKQNLRTGSWKKKEKSMKKERWFLENGSIFLKELIVDCNGKSIPIRSFTSSQIRKATKNFDLSCFVAEEGFYIWYKGVIEDRSYMIKRFSEYKVTDYRVSEVYKDIVLSARMSNHNNFLKLLGCCLEFPFPVLVFEFAEHGVLNYRGGITVNGEESLLPLSLRLKIGKEIANALAYLHMAFPKIIIYRDVKPLHVFLDNNWTAKLSDLSFSISLEEGKSQIEAEDVLGTYGYLDPLYFATRIVTEYTDVYSFGVFLMVVITGISVYFTGSDGYPVGILGYMKGLAENGKLNEIVYPMIMKEMTSAQRLQVEACVLLALRCCEERVEDRPKMIQVAKELKRIEHHVLRS
The following text describes a protein:
Function:
Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development. During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSRSFYVDSLIIKDTSRPAPSLPEPHPGPDFFIPLGMPPPLVMSVSGPGCPSRKSGAFCVCPLCVTSHLHSSRGSVGAGSGGAGAGVTGAGGSGVAGAAGALPLLKGQFSSAPGDAQFCPRVNHAHHHHHPPQHHHHHHQPQQPGSAAAAAAAAAAAAAAAALGHPQHHAPVCTATTYNVADPRRFHCLTMGGSDASQVPNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQRNSHAGCKCVGSQVHYARSEDEDSLSPASANDDKEISPL
The following text describes a protein:
Function:
Transcriptional repressor which promotes neuronal differentiation during embryonic and postembryonic neurogenesis. Together with components of the MuvB corepressor complex, negatively regulates the expression of non-neuronal genes during neurogenesis. Required for the generation of postembryonic neurons from epidermal cells.
Subcellular Localization:
Nucleus.
Sequence:
MSSISNNPDFSSIDPAVLMSLLMKSSGSLPTPPDTHSDGSESPDSTASDSSDKKRRRKPESKDIVRVAEEAEAAAATCSSIPSSSDTKENETEEDQNMTCDTTTNNAQKPTEQTATSADVVTSSVPSGLEGVPSFLFSQFMAPSFQKQLEIFTSGNMMSATHSDTSPSDVDSVLDGGVVTAEETSSSKSPMMTSSDTPKTPLTASSPPHSSGSESRVMSPITHTNISDELSISTTPTVAFTPNGSIPSPGTGYSWSIRREGKLACPTPGCDGSGHQTGLYTHHRSLSGCPRRPDKTVIQMLALRQDTVLRCTTAGCSGKGHVNGNRTSHRSLSGCPIAHQEKLARKGIKTTPQRTKTPIKGISISDECPLDLTLSGLPAGLSAQQLLAAAQAGLIPSSQMMDALFQQFSQTQPLATLEEESKKENEMEVDVETTSDDIPTLIKEEEEVKCESPVPSVIPEIQSTPSRPVAAPVAPGSAEKSSPTSQMLLQMPGFSEALLKMTAPQVPFPQYSPQAALFGNQSALLAQIMLTQLQMQQGF
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSVLKQIPIWLKCLFWVFGILQLSENNEETLILKVVPIPFWCYYTAIVIRLWTSMSSSQFYYYGISDILQYTDILCDLMVITSLGIHFVFFYKRNTKLQNLVVEIDRIEIKHTKQKSINWLRIINLSGIFLNLFLLFSGIGVIVDIEYQLTYYFGSFLSGLDVILVGVFLDNLKNKFKWINQRFFETKQETDLVQIFPSGHLLRARTKRKTIFQIQNLAQIHYSLVTLVHKTIRIFEITILFGTASWFTIIINEIYYLIYMVSQYSSKLDMSHWAQLPLVVHYCIWIYFQIRIWNDLQEEANKTVFYVHDIWNLLAIKDENNTDMRYLHLISTKLMSMKLELTAKGFFPLNWSLLYTIIAAVTTHVIILIQFKI
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
NQPFSQSMMEEALESAELIIKKWDPNSQSYTKIISLFRHSRKQAKEFIRCVRDLRRAMHFLVSQASKSDKLVLAQNLMQIGMSTLEKEFFQILSSNRDHLDPDSVSVQSTISSNSEFEVYMEYDEDDDDELKKAGESISQVEKASALVMSDLKVIAETMICCGYGKECIKSYQLIRKSIVDEGLHLLGIEKVKTSHFQKMDWHVLEHMIKNWVKAAKIGVTTLFRGEKLLCDHVFSASVTIGQSCFNQIAKEAGLNLFMLPELVANKEKKQHHHERIFKLMDLYAAISDLWPDIEMIFSFDSLASVKTLVLSTLKKLKDSIHTCLKEFETMIHKDSSKEISPEGGVHKLTRTTMSFLSLLSEYSRVHVLSEILTEHPLKTNTRLLESYFTAPILEDEHVNNHACSVHLAWLILVFLCKLDTKAESYNDVSLSYIFLVNNMQFVADTVRSSHLKNILGDDWLTKHEAKLKSYAEKYEKTAWANVLVSLPSKTSAKLSPEEATTCFKRFHAAFAGAYLKQSSCVIVDAKLRDELKVSIVKKLVPEYREFYEKYLAMLRQDRNIEMLRNIYILAKLERIITAARLCTSQAELKDGTTRAPIVWFLSCQRATELKPSLENPDHFETPAVIFNSRFTRLQTVHCVHNVIEFLSDDSPDMDVIGISGSLGRFKSHVSNIVFDVFIATCQDPAQNMESSQIDGSH
The following text describes a protein:
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MAQAEKKLNSGGGFFGMFSNPTLKAEEAASLYRDAGVKFKVAKMWQEAGEAYIKSAEAFVKAELPHEAATSYQEAVTPFKKVSQDDAVMCMEKAAATYLDMGRFAMAAKQFKSIGEVAEKDLADLTRAKEFYKRAADAFESEDSQTSADKLKLKIASISAQEEEYEEAWTLFEEVVERMVDNNLLKFGSKEYYLKAGVCRLLSGDVVATKRAFEGYTVQYSAFGDTREWRLLQGLIEACEENDVEKFQQALAEYDSVQKLDSWMTTICLRLKKTLSAEEDIL
The following text describes a protein:
Function:
May activate the NF-kappa-B signaling pathway.
Subcellular Localization:
Endoplasmic reticulum. Lipid droplet.
Sequence:
MVCIPCIVIPVLLWVYKKFLEPYIYPLISPFVSRMWPRKAIRETNDKNKGKVDYKGADINGLPTRGPTEMCDKKKD
The following text describes a protein:
Function:
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
RCRKTYEKENLCLYGIPNETWEVNLSVEEVPLELPDPALGINFARDGIQEKDWLSLVAVHRDSWMLSVAVYFGARFGFCKSARTCKFPPLEDREKSMAFFAGLDFFGGGILTKEEIGGLVVVDGPSGDRAVGSGSGAAIGAIDAPLTVFKTNHYEYDHIGYTNFASPSECSACKCQDCRAKHDVVINVINALTASVKELTSKRGVIPSKRILFSSTPLEINAKRRKKLISKALSSIQKRKIATPLSMCCTKQYTMSKGEQHKPKKSNIYVF
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MSPVKVFGRAISTNVSRVLVCLEEVGADYELVTVDFLAGEQNSPEHVERNPFGKIPALQDGDLVLFESRAIAKYILRKYKSSKVDLLRESDIREAALVDVWTEVEAHQYYPALSPIVFECIIFPIMRGVPTNQQVVHESLEKLKKVLETYEARLSGSRYLAGDFLSFADLNHFPFTFYFMATPCASLFDAYPHVKAWWEGLMSRPSIKKISANMPTKF
The following text describes a protein:
Function:
CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
Sequence:
MRNQAIQVATVSRRRVSERKVFPASVEEAATRSGTVSMPVGSRVQQINVDIGDSVRKGQVLAVLTSSELGGAKADLLSAKASLLASQARLIAAKRQSDRETYLAGRGISSQREQQEAQAQLASAQSEFAGAQSAIEAAKARLLAFGLTEEEINRLQRGNDITPRLSARSSVNGQVILRKARVGQVVQPGEALFTISDLSEVWVVLKVFQSELGRLHVGDSVRFTVRGLGNTEVQGRVVRIGEALDPQTRAADVRVVIPNRDRKLKPGMLVQAEVDLGGSSREVLAVPDKALYDVGGRQVVFLRESTTRFMPREVQLGTRVGEYVEVIGGLKPGDAVVVEGGFVLKSEMLKS
The following text describes a protein:
Function:
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Miscellaneous:
MISCELLANEOUS: Purl possesses an auxiliary ATP Binding region which is not catalytic, but able to bind additional ATP. The conformational changes associated with its binding could have a regulatory role in formation of the PurLSQ complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLRYLNILKEKLGREPTFVELQAFSVMWSEHCGYSHTKKYIRRLPKTGFEGNAGVVNLDDYYSVAFKIESHNHPSAIEPYNGAATGVGGIIRDVLAMGARPTAIFDSLHMSRIIDGIIEGIADYGNSIGVPTVGGELRISSLYAHNPLVNVLAAGVVRNDMLVDSKASRPGQVIVIFGGATGRDGIHGASFASEDLTGDKATKLSIQVGDPFAEKMLIEAFLEMVEEGLVEGAQDLGAGGVLSATSELVAKGNLGAIVHLDRVPLREPDMEPWEILISESQERMAVVTSPQKASRILEIARKHLLFGDVVAEVIEEPVYRVMYRNDLVMEVPVQLLANAPEEDIVEYTPGKIPEFKRVEFEEVNAREVFEQYDHMVGTDTVVPPGFGAAVMRIKRDGGYSLVTHSRADLALQDTYWGTLIAVLESVRKTLSVGAEPLAITNCVNYGDPDVDPVGLSAMMTALKNACEFSGVPVASGNASLYNTYQGKPIPPTLVVGMLGKVNPQKVAKPKPSKVFAVGWNDFELEREKELWRAIRKLSEEGAFILSSSQLLTRTHVETFREYGLKIEVKLPEVRPAHQMVLVFSERTPVVDVPVKEIGTLSR
The following text describes a protein:
Function:
Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MDLYDDDGESAQSEKVDVPSEESTIAGPETDIPAETIEENVPEVEENTLLEEDSLVDVDSPRPSQQRSKPSKSKRKRKRSSSGESSAAEPEIDAGAKVKGPLSNTNKEINVGTEFQAKIADLNLNDKACNEDRDDQDELIWNTPETIDDEKLEAFIRESSDRYLIPIDRALYILTINNFNFDSAIAEVARRNELKDVWTDQEITLFENCYQIFGKNFSQIRSALCHRSLQSIVQFYYESKKRVKYLNFVNSKCDDSSSSEETETPSPYPEAIFESMCDNCGEKAENMQINNAMNRPECRACLIYFNQTGVPRPTSLRLVLAERIRNQVSCPDNMKEYMKDFDKLSAQATGSTFQKRIIVKDQCVEYIIDVDKIPSSSCTENGNVGETSSPSAQKTEIQSESDGSGPLIWRHKKTVCMEEIEVLADDSRRKMFEACQHGSKVDIKLVASWKNDMTNLRKRVEQTYYDPDLNPTYLFSHDRVHYSQDWTQLERSQVIRCFNMYGAHFEHIADVIGTKTPDQVYQFYLENQKAIDAADEEFLADMKNPERLADMEEEEDSI
The following text describes a protein:
Function:
May be involved in mitogenic function of FGF1 (By similarity). May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).
Subcellular Localization:
Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.
Sequence:
MTSELDIFVGNTTLIDEDVYRLWLDGYSVNDAVALRVRSGILEQTGATTGVLQSDTMDHYRTFHMLERLLHAPPKLLHQLIFQIPPSRQTLLIERYYTFDEAFVREVLGKKLSKGTKKDLDDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQQHFLLSDRLARDYAAIVFFANNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVDSQVDDMDVDLDKEFLQDLKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMETNFKNLSRGLVNVAAKLTHNKDVRDLFVDLVEKFVEPCRSDHWPLSDVRLFLSQYSASVHSLDGFRHQALWDRYMGTLRGCLLRLYHD
The following text describes a protein:
Function:
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAPSNVGCSLRAAAEFAALVASAQGWLARRATATGVGAFRQGGSGVAGLPDAPCSSGQHGPPSHPPASDELHTAWALHAPHAPASWLRVSHPTGHSPQPPHAELGLPPPWHPAAAGTGGATAPAHPRHAARHPPTVDAPAAHREPHGAGGPSRGDVLATSPGVMQSGTGLGPGCGNSTSPEAAGAARSHLASLLLAMSARPRSSLHNSNLTNRLYATAPADWVSGGTRGPAGAPARTPPGCWARVWSRRHYAAASTAAAHALNAVPDPDPEAARPPPGGEGQGDGGGGAGGGTTNGAALSAAEAEGQGRVAAAGGPAAPGLGFVSGGYDVSQFPPERIRNFSIIAHVDHGKSTLADRLMEATGALGGRATHSAQYLDKLQVERERGITVKAQTVSLVYRYPPGPGGQPYLLNLIDTPGHVDFSYEVSRSLAACQGALLVVDAGQGIQAQTVANFYLAFEQGLDLVPVVNKIDLPAADPRGCTAQMAAAFDMDPAAVLLTSAKTGVGLEAVLPAVIQRVRPPGGNPDAPLRMLLFDAFHDQHRGVVVLVEVVDGAVAVGDKVAMASTGAVYEVQECGLQAPERHPTGRLLTGQVGYMMCGIKDLKAARVGDTLYAARPGVPQPPSLPGFKPAKAMVFAGLFPLGGDGQEFDALAAAMDKLLLNDASVVVRRENSDALGPGFRCGFLGMLHMEIFTQRLEQEFGAAVVTTTPMVPYSLQMPDGSEVTLESAADFPLDKKISAILEPTVTATLITPDASVGRLMELCAARRGEPLEHSSLGGGRTLLRYRLPLAELAGDFYSAVKSRSQGYASFDYEEGPYRPADLVRLDVLAHGRPVDALARMVARDEAATLGRALLGKMKDLLDRQQFEVVLQAAANGKIVARETLKALRKNVTAKCYGGDVSRKRKLLDKQKEGKRRMKRLGSIDVPQELFPELMKTR
The following text describes a protein:
Function:
NADPH-dependent aldehyde reductase involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Reduces commonly detected inhibitors in biomass conversion hydrolysates such as furfural, 5-hydroxymethylfurfural (HMF), cinnamic aldehyde, benzaldehyde, phenylacetaldehyde, and anisaldehyde.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTTDTTVFVSGATGFIALHIMNDLLKAGYTVIGSGRSQEKNDGLLKKFNNNPKLSMEIVEDIAAPNAFDEVFKKHGKEIKIVLHTASPFHFETTNFEKDLLTPAVNGTKSILEAIKKYAADTVEKVIVTSSTAALVTPTDMNKGDLVITEESWNKDTWDSCQANAVAAYCGSKKFAEKTAWEFLKENKSSVKFTLSTINPGFVFGPQMFADSLKHGINTSSGIVSELIHSKVGGEFYNYCGPFIDVRDVSKAHLVAIEKPECTGQRLVLSEGLFCCQEIVDILNEEFPQLKGKIATGEPATGPSFLEKNSCKFDNSKTKKLLGFQFYNLKDCIVDTAAQMLEVQNEA
The following text describes a protein:
Function:
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Rho-independent transcription terminators may serve as polyadenylation signals. Seems to be involved in plasmid copy number control.
Miscellaneous:
MISCELLANEOUS: Uses the non-canonical initiation codon AUU, which limits pcnB expression.
Subcellular Localization:
Cytoplasm. Cell inner membrane.
Sequence:
MFTRVANFCRKVLSREESEAEQAVARPQVTVIPREQHAISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNVSDRTTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLETAQKIAQESGLTYHDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAAYDLLALRAEVERNAELQRLVKWWGEFQVSAPPDQKGMLNELDEEPSPRRRTRRPRKRAPRREGTA
The following text describes a protein:
Function:
Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region.
Subcellular Localization:
Cytoplasm.
Domain:
This protein has an antiparallel four-helix bundle architecture that represents a novel DNA-binding fold.
Sequence:
MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISAVQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAVGESATEEPMPDASNM
The following text describes a protein:
Function:
SOSEKI proteins locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes.
Miscellaneous:
MISCELLANEOUS: 'Soseki' means cornerstone in Japanese.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The DIX-like oligomerization domain is required for polymerization, edge localization and biological activity.
Sequence:
MPSLRTERRSFGMETPRHSSFRMAEVLYVLSCGGQLEHPHMINVQYPVHQPGPTLRDVKTRLIALRGRGMPDSFSWSYKRNYKDTFIWCDLFDDNFILPLSESGEYALKATKRFDASQVKYLRPPRRSENLEAEGDVSMVVKKGLVLISDTGSVTSNRTMELNKQLMNSLSHSRSAAAVRNNEHSDVSSSDTHYSYEDVIERKDYPARCKSNSGATKRGKASVTPKQCHPSSRPAYWEFSPQGNRTGREDSLMTIGLTKHVVEENEGPTTPRAPARRRTWKKEIDKITIFRESNNSESSDDEQPSVQAETHVSKLSKSGGSYSAAPEDLFLYILRKATRLGSFKPRVCTEVDVVDSTQSKTKMLFRSKTKDEVNRLLYHSPLKQDQSIKK
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MGLFGKDRGERIAEFPCYLLETGTHLVPLPGILYNLVIERTYGERILGQFRGIGEAVDGALTGAGEAAEVPGRVAEVMKAFQERYDSGDKTQAVYICLVTEAAAGRHIGCIARLTGARAEGGELSVLLRGLVRAVVGQPVPSRRNEMWNGSVTVLDDAQRVATWGARQLDFARQGVFGAFEELDAGIGTFTARFKSSQKRGADGAAHLLTLSPLANTLFFHFSRSSFERSWKILRTMMHGFRDAKKDIRTAMDMLSVADLTVGLLPTTTAQRLEFLQAEDPAARIKTFVRHMQQLLEVFGSLYRATEYVHDRFETHGPIAKSQLIANQLRSLRFYIDDIKRNKPESGPGGRSRRLLPRPASGNSAAAGEEDDSEDSELVAIKRYVDEIEVKGVHADGVKMLKKDYRSLSKMHVQSTEYQMLRNYFDFIMGIPFGIYVSTPEIDLVASSRKLDNDHYGLVQVKKRLLEYLCVLKLSANSPGVTADAGAIEDGSATKRAVVYENKAQEQRKTKVPFLLLVGPPGVGKTSVAKSVADVLGRRFQRISLGGIHNEAEIRGHRRTYVGAMAGMIVNALCKAGCMNPLILLDEIDKVLSVPAGAGASRLNGDPGAALLEVLDPEQNHTFTDHYVGFPVDLSQVLFFCTANDLSGMSEPLVDRMEVIHIEGYTYEEKIAIGRHFLLPKQIRLNSFDMTGINLSLTDDAWRTVVVDYTREAGVRNLDRQLGAIVRGKIVEYVENNMSGSGDDVVTQKNLPKFLGLPPHSLREEVTQTTSFAEKYGVVHGLSYNSDGTGGVLVFEVIRSGDSRDKRLTVQTTGNLGTVLSESVSIATSLVKSLLARHVVHSSADDTSVAEFFRSECHLHVPFGAVPKDGPSAGAAISLALLSLALKRPVDPALCVTGEITLRGKILPVGGVKEKLLAAQLQGMGLALVPRGNRNDLVELAEDNAETQQRLLADPALPELATLQHKLGMAVHYCSDFRDLVLHAWPTADNLWHACEDSSVRPQL
The following text describes a protein:
Function:
May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation.
Subcellular Localization:
Cell junction, adherens junction.
Sequence:
NLSFLLFSEVVSAINECAFMINCQTVTLENSDYSSTLQRDAKGQYLFDLICHHLNLLEKDYFGIRYVDPDKQRHWLEFTKSIAKQMKSQPPFTMCFRVKFYPPDPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAAILAAYILQAEIGDYDPGKHPEGYSSKFQFFPKHSEKLERRIAEIHKTELSGQSPDTSELNFLQKAQMLETYGVDPHPCKDVSGNPAFLAFTPFGFVVLQGNKRIHFLKWNEVTKLKFEGKTFHIYANQKEDKKIILTYFAPTPEACKHLWKCGVENQAFYKLEKSSQVRTVSSSNLFFKGSRFRFSGRVAKEVMEQSAKIKREPPEIHRAGLVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSASHGDSFVPRSRSLAADACEGGSAVIADEAYSPSDSVLPTPVAEHSLELAISRQINGAPCSIEEEKESEAGTPTAGEVAEFGPDGKALSPEHAGEAGASPLGEVEQVNKFVLSVLRLLLVTIGLLFVLLLLLIVLTESDLDVAFLRDIRQTPEFEQFHYEYFCPLRRWFACKFRWLVGLLIDT
The following text describes a protein:
Function:
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGGVLGLCTAASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYAFFLLIGVAVACVMLIPGMEEQLKKIPGFCDDGMGSSIPGISGHVNCDVLVGYKAVYRVCFGMAMFFLLFSLLMIKVKSSQDPRASLHNGFWFFKFAAAVGITVGAFFIPEGPFTTVWFYVGMGGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYVALLSATGLNYVLSLVAIVLLYVYYTYPEGCAENKAFISVNMLLCIGVSIMSVLPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPDRKCNPSLLSIIGYNSTSTPGQVKVVQWWDAQGIVGLVLFLLCVLYSSIRTSNNSQVNKLTLTSDESTLIEDGGRSEGSMDDSDNAHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYSPDSSYEMMTSKWPSVWVKISSSWVCIVLYVWTLVAPLVLTNREFD
The following text describes a protein:
Function:
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKFLIDVIVEIPKNSKIKYEYDRQTGQIRVDRILFGSESYPQNYGFIKNTLDWDGDELDCFIFADQPFLPATVVPTRIVGALEMIDDGEIDTKLLGVIDCDPRYKEINQISDLPKHRIEEILIFLKTYKLLQKKTVIIKGLKDVCWAKKEYEICLQLMKDYGHLSKDQFIQKMQILHPEHYQK
The following text describes a protein:
Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Subcellular Localization:
Nucleus.
Sequence:
MSLDTLLEAAKYIEYRSEAKARGEIPHDYQTFALQSKAVAAEEYRAQQQQSRQQLLQHASRCDNNSSDSYSSNHFDDGKEKRRRAHLKECFETLKRQLPNMDDRKTSNLTILRGALRYITSLKRREREYEHEMERLAREKIAAQQRLAVLKKDLSLQLDYLDMSAILPDQDNETTTTASGNSENGKPVSSSIVNVSNNKPVASTSSMTSLVASYGGSHPSATTGATVVVSSGVGAAPAQTVANTRGLATLGVAPTPSLANSKCATALLAPSTTANLATLVTSQQPQAATTGLGLLSHAVTNSSAATAVQVVANPVGGVKVLAGPAPSSSPPSSTNNGGHLVALTVAPAVSTLAPVVVAPPSSTLAAMASSVAPPKSLVRTTSGANVGRAGGAGTAPVALVTAAQAKSLFLGPHGVAVTASPVGSGGVGVATTGVVQRRGLPQVLTPRALATSTVLSGTAGALKQVRAGTAPGGQALSQLAAHVTHVAAASSPTAAVGQLPLMAPLSVVGHLPALLSQQFLSPGANLGTLTAVVKPLVVVSLPNVVAQPATPTSVGTAQ
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MDEDFSFDDIDRWEIGKERQKFRRYRTRHLPSTSLLAKDLQIPAKVERRPEPELPSFPEEPVIDKQESPVAVPRIKHVKEEPDQPSDAGEDSFERFASGVDTWLHGFTSLSELLSEFEDICRDLAEAVRDEAAEKHRAVEDRVLRQKAQLLHSEASSWALLWHLYGKEDSMEDNQKASTSAQVASEFVRNDETAQTCLRLVQWLESLASKELDLEKKRKGWYAGSYTQKLGLWDQTKRAIKKNIGTHYVRHLDPDAPTREGLQLHPEDQKLEDGLLEDVWKLIRAGRITEAQDLCRTSGQAWRAASLGGCLTGYSPTMQNAFNERALEAIELDGGLGRQRKLWKWACFCASEVFQKIASSEGGRYESAVFAAQCGNVNHMLPVCADWESAFWALVRSWLDTQIELELSDRHPSSTIDSSSTWPDPVVEQQPRDFINLFQKLYSGNLVSESVRRSCKEQHRLIQMHVVVSDIAALLEMLKTWILPSRDDSSNIKPHGHPQMIRFAAHLVLVLRSILPEGLKEQYADRLELVGDLILNTYVIFLFTQHKEELVGPYASHLAPHLCVDLYVHMMELRQNDSEMVKRKFFSSAMEYLPFYDDGKKGSVSAICKSFLEKSRELKPSVSNVKAEDSERVENLQKGHSVQWMCFTPRAGLPDSELMRIELLALALQHSNILLREISLTSLWRSVEIPEGSQALFGHLAAPLGEEADSVLLHENYDTKENYQEFLDWQEYFSCDAHYRSWLSTIENFSSPEERAKSFAAARQALDTAAAFLHNSEGKWLLGSEVINDEAFESVELFATVVLSRPSDPYFVPDPTVCTALNSALYLCMGELASSQRNLTVNVAVNPQNNMLLDIELKCAALEGEGIESLVSSDGGFLSAIMAAGIKGELPHFHPGVAIEVLRMDAFSIHSDGVRRDAPSVARGICRRCCLPELVLRCMQIRAWLPVSEMTAGDDPEDDLIQLVASGALQGLFSGSQLEEFLLLEREIVLRRMEAGEDEPRVSEAEDMLHE