lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux routeby exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1: 1. Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration. May mediate transport of ornithine in retinal pigment epithelial (RPE) cells. May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTPWSLLGCIKTLKKSKKKRANTGPMENEPEKMQMKQEITLFNGVSLIVGNMIGSGIFVSPKGVLMYSASFGLSLIIWALGGMFSMFGALCYAELGTSILKSGASYAYILEAFGGFIAFIRLWSSLLIIEPTTQAIIAITFANYIVQPIFPSCQPPYEAVRLIAAACICTLTFINCVHVKWGTRVQDVFTYAKIMALLMIISVGLAKIVQGESDNLKSPFQGSTSNIGSMALALYSALYSYSGWDTLNFVTEEMKRPKRNLPLAIAISMPIVTIIYLLTNVAYYAVLDMPDVLASDAVAVTFGNEVLGYAKWLIPIAVAMSCYGGLNSSIIAASRLFYVGARQGHLPASLSLIHMENFTPVPALLFNGLIAILYLLVEDVFLLINYYSFSYWLFVGLSVAGLIVLRITQPLRQRPVKVNLFFPVVYCLCSLFLVLVPIYCDTINSLIGIGIALSGIPAYFLGVYLPEEKRPKCFTWIYTSLTKYIQLLCNCCMTDPDNDKEKEK
The following text describes a protein:
Function:
Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1.
Subcellular Localization:
Cell membrane. Cell projection, dendrite. Cytoplasm.
Sequence:
MSCQHHKNGPTVSFNAIQIANARMKGSHSVKRHRITIHTSHTDGRNEVASRPGRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGCEEEELKPFVEPELDISDQKRIDIMVGMGYSREEIHESLTRMKYDEITATYLLLGRKSTELEVSDSSSSSNLSLAKARPNSEHNNGQSPSHLKVQKNASTNQKQRRYSDQAGPTIPSVGYPKRSQTTSAESEHKEEGSAQARKSSSSGSRGMAPASPMLGNANNPNKADIPDRKKSAGAPGNNSVSSGMTRRNTYVCSERNATDRHSVIQNGKENSLSEMSGCVSTSPTAYAVALASSSASVRLRHQKAASLSASGHTCRATLPTSDASADLFRPNTSTAQTSQRNPGSSTHSISSATPPDRLRFPRGTLSRSTFHGGQLRERRTATYNGPPASPTLSHDATPLSQSRSRGSTNLFTKLTSKLTRRNMSFRFSKRVPAECDRNGRYDDSSRNVSGDQKEEHKDAKPRSLRFTWSMKTTSSMEPTEMMREIRKVLDANNCDYEQRERFLLLCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Sequence:
MYQKKSQLEHILLRPDTYVGSIEKHTQNLWVYENEKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMDSVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSSEFVIETADGRRLKKYKQVFNDNMGKKSEPIITKCKAGDNWTRVTFKPDLEKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVRSFQDYVDLYLKSASSIQAEPPKRYHIRPNERWEIVVTLSEGQFQQVSFVNGIATIKGGTHVEYITNQIANFVMTAVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRANSFGSACELTPDFLKNVATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQYIKQILGLQQGKEYNNARALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYEAWKESLRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEKLNCLTNELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPRDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLEGETMLPMDPWYRGFSGTIEKTATKEGGTTYTVSGIIEEVSDTTLRIVELPVRRWTSDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRILLDNLEMELLKLENKVRFILAVVNEEIKVSNRKKVDLFHELQAKGFTPFPKKTKSVEPEIAGASNETDEAEESPEVVKGERISDYEYLLALPIGTLTIEKVQELCSDRDKLKGEVDDLRKATPKSLWLNDLDYLEKELDEMDRNDAQTMELRKQQREKANIDLKPKVSRNAPKAPRNSKKTSNVETVTESMDTTYSSTTTEVANNPVVKPKGKAAPRKAPAKKKGKAAVLDDDEDDEDDEVLELKDRLAAYKIESSPEPSEVSAMETEVQEVQQQAAKKKEPSKRAPAKKKTTAKSAQISISDDDNDGDFEIKEVDPPAAKKGGGRGGGGGRKAAAGNSKTTKPPAAGAKLGQKLITQMLEPAAENSGISPEKKVRKIRASPFNKKSGSLLGRTIGEEEEDENDDEGKLMGSASFETSEEVQLARGRSRRANRTTQVRYVLSDSDGEVASQDSDFDEDEASLDED
The following text describes a protein:
Function:
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.
Miscellaneous:
MISCELLANEOUS: Present with 1950 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MGIIEEKALFVTCGATVPFPKLVSCVLSDEFCQELIQYGFVRLIIQFGRNYSSEFEHLVQERGGQRESQKIPIDQFGCGDTARQYVLMNGKLKVIGFDFSTKMQSIIRDYSDLVISHAGTGSILDSLRLNKPLIVCVNDSLMDNHQQQIADKFVELGYVWSCAPTETGLIAGLRASQTEKLKPFPVSHNPSFERLLVETIYS
The following text describes a protein:
Function:
Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGNLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGALSSGGGAPSYGATGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
The following text describes a protein:
Function:
May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.
Subcellular Localization:
Cytoplasm.
Sequence:
MGTQTFFQHREEEQKEERQQRLQMTSMTSKKRFKTSEEEETFSLSELSIAAALALASETPRNYKLRREAAILELEQRGQKRVCFGNEMEKLEEEVIKNCRLLRVRADRRALRRKAVEKAHREKEYIELCSGRAPMFWIPLRVHAVWERMEVTLTCTVLASPLPQVTWYKNGVPIDLRLAPAGKYKIKNKFGMLTLRISRCSMEDSAEYSVVIENQYGKAYSFATVLVRKYYGKESGFDSEIYRRSLIAREADFAFSLKPLFSREKEPFTLSCYFTSDLLEHQRNVTWFRDGELLQNSERQELKYQDQEASLRVPCAYKEDEGFYTIRIPSLGGCKEQTTYVFVQDAAAESAGAPGSPLNVKCHDINKDCLILSWIAPSANGGSPILGYFIERCIAGSENWVPCNEKPTKTCRYPVLGLAEGQAYQFRVKAVNKAGISHPSKTSDPVIMYDPSKDKRVTVIPYDEGKMIEIFKDDLEGHIKIPLPPTNVHTTEVREDYVALAWDEPDPRGRESLQYYVEKSLVGSNSWQMVNLDMPVNSPRFALFDLIKGKPYSFRVRSVNKYGISEPSLPSEPITAGAKLAPLPPPSQVLAFRDTKTSVALQWDKLKDGLEPLGYYIYCRESGTEEWQTVNNKPVMCNEFTVPGLKPGKEYVFCVKSVSEAGLSESSPETDPIIVRPAIARPSAPCGFVLLSCGKANMTIGWKPPKHNGGTKILGYFLDQHDASELDWHEVNIQPIPQRVYTVSNLEEDHLYEFRACAMNMAGVGEVSEPSDLFKCEEWTMPEPGPPYDVKFTEVRDSSLMLHWQAPLYIGAGPITGYYVDMCEEGTEEWKQINKQSTATTHMKVSDLDTGKCFIFRVRALNKAGIGPPSLPSDPVVAKSKPGTNEIELGVDEEGFIYMAFEAPEKNDSSEFIWSKDYEGPPDADRVWTEEKGNKSKLILKDPSEKDLGIYSVEVTDVDDDISASCTLTQEDLDKLLKRSHEIRNPLIKLISGWNVDVLEKGEVRLWLEVEKLSPNAELHLIFNEKELTSTPTHKINFVKGKGLVELIIQNFCDDDKGVYTAQLQDGKAKNQFTLVLLDESFDTVAKEADAKQREWKKKQGPYFVENLKWKVTENCEVLITCKATNLRKDTNFQWFFNKKARTDGMFDPQTGIGTLHIEKITKADEGQYKAVVSDDRGEDYTQLDLIKGTFEDLLKELCRISALSATPLKIQPTDEGIKIYTDVKYYTDYMKTTWFHKEKRLEIRDKLKAGSTMNQIWLHILNPTDTDKGKYILELFDGNDSHKLSTDLSGQVFEDALAEHRRLKEAAIAEKCRARVVQGLPDVATIMEDKTLCLTCCISGDPYPEITWFKNEKTIIFKDRYRMDVKGTVITITIEKVCNEDTGKYSIYVKNKYGSETGQVTVSVYKRGEIPIGVEEKEVPSETITRKPK
The following text describes a protein:
Function:
Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates.
Subcellular Localization:
Cytoplasm. Nucleus. Vesicle.
Sequence:
MHSNLWIFIWRRKLSFLLVVSGLVLLGLWTWAILIDTTASAQPPAAPISNSERQQQQQQSTGYQQVHIIQKLIEQANRVLRAERLKDNAVEKSPSPVQRLGNVRSLRPTQAKKAPLPMSESFLFEQERLKILEQQQRQRNAGMEELNANAEDERMLSSAERQTQYEHELQRMGVPVVAGIGPDGPRAPAERLVHLDLKGAPPKLSFLKQLLPVLRALGATGLLIEYEDMFPYSGVLQPLAAHNAYKEDELRDFLECAALHGLSVMPLVQTFGHMEYVLKLSGFEQLRELAESPQSICPSQPQSMALLEQMLTQVIELHSQCLGQATPATNVPVARIRFTHIHIGCDEVQRMGECTTCRQRLRSELFLSHVVSMAHFIRRQWPHLGVVIWDDQLRSMSLSELQHSQVGSYVEPMVWVYASDIYRFIQPQLWDTYAKVFPSAWTASAFKGAFGESLLVPPLQHHLENNIRWLAVIAKEGGRFSKGLRGLALTGWQRYDHFAVLCELLPVGIPSLMTSLSTVSKGYFSTNPRDNELLRVLQCVFQPDSRRSGRPWLELHPNAHHSQLFAVCNYPGHLVFKYALRLFDKLAEIRLYLQQTRDQSAWLSDYNVRHNFSSPLRVRELTARTPMLIEELRAMAREAQQLLWEVYDEYTVTEFVEQHIYPTIEALQRQLARAEMLLQRRTWPQRPLPLPLKVQEDMGLVTHQQEQQ
The following text describes a protein:
Function:
E3 UFM1-protein ligase that mediates ufmylation of target proteins.
Sequence:
MMASSDWIEVQRLAAEFQRTQLSSTLQKLSEKNCIEIVSKLIELKLIDVFYTNDGKEYITLEQLSKEICDDLYLHGGRISLTELVPILNISYHAIESRAQNISQTKSEIHLVSGQLIDDDHLDRIAEEINENLQQSGQITVVELSKQYELPMEFVLQLIRSRLGTVIQGQQDKHDHHVFFTEGFLARNRSRIRGALSAITVPTSVSTIIAQNKLPERLFFAFADELINTKRIQASLSGGRQVNVATFIPEIHSRSQNEWIDNFLKQNGYLEYAALTRLGLGDPKSFCRKRFKDTSLLYLSSCCVGSNILGQIEAAIEEAISSQSWVEVLPLLPSVFDDEDAEQIIQHVLKTSQNIPDKDALVIGQSAVTSNSFVQNLKIIFKPMIEEKASEVVASGDYLQSLADQRNAKGKSFKPEQANEKKDRKEERRKKANEGKLGGGTQGRETKTRATKKKYGKGKNDSDDENEGDVVGTNSASLELEFMSIEEISNVLKKKENVSDAPDEFVEDIATRLYPSLQASFQEAARLAFEAMLSSTSGQRRQTHSELQDRLQLLLQNIKQGEKAIQFFTSLDVQQQLCRHLLKTSGSELVNELVSYVSQDTSVASDSKDLSPEARQKIISGLPQNVRVPLQGLHKATQGANVEEFLSETEVALSACDVVLRKVDKKKDKAIPTQQRHLLIEQLNAAKDAALVLHVAVLLLFHTVTQTVLNASGRFVPQIITFLQSHLSPSTAELLSTLQGLVIQELTSKGDEELLETIRQKMEDLIPRVRETAVTFKKSATQD
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MENGGWNFFSNSIESCSSNNGGNGGQNSNYTHAWDFWQLGSTSTSTNSSQSQLIQWNYNNTFNQDPITVGQKFDYTCPLNSSELIARRVNTSIVSSSEYFIQEERDHNLMCLNLNLGKRHCTENYEPPQGGGEVVGFVMNKRGKQHFPGGDGAAAAVEIPVAVAPRCQVEGCQVALVNAKVYHRRHKVCAMHAKAPKVVVLGLEQRFCQQCSRFHIVSEFDESKRSCRRRLAGHNERRRKSSQDNYTNTRNPSQGNYRNIAVNEGRAHSLLSSKNDSWISKGNLPGRCSVTINELIAESRATRLAQQLIIDKDWHRHQHYPVENLNIQLKNGSSTDHKREQVVLKSNGWGRANDAAGNLTLDLMHVRNSELGFLSEQEQLKEEGDEEGCPEHWNSFAGAHVA
The following text describes a protein:
Function:
Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWGGFKKAINRAGASVIVKDVDKTMDKDFDVEERRYKTLKTAGTNLQKAAKGYLDNIRAITNSQVTIAEIIYNLYEESKQGQSLYSNVGTYYMQSVKEFDEETVKQIDGPYRETVLDPIGKFSNYFSEIDEAIKKRAHKKIDYEQCKAKVRRLVDKPAKDAAKLPRAEKELSMAKEIYDELNDQLKAELPQLIALRVPFYDPSFEALVKIQLRFCTEGYSRLAQIQQYLDPASRDEYANGLLDGKIDDMLAQMQGLSITSLGK
The following text describes a protein:
Function:
This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate (By similarity).
Sequence:
MVATDSSDQVAKFDVSHKIIEDIVYSLSNRIFSYAEHVPLNRYLTQWNNSGRRNGFSNNVELFNLEARSGASAFLLGSYTAAISSPGVYSMMTPSSCLSLLNPLLSNIIPFYGASKPLVVHVAALAYLEQTYCADNVSVLDFSYANNFTVFASQSNVEAAHLALASTLAAKAAPVIHVYEPDAIVTTTDPSLPLLDSNAVVECFNSYQSEADPVSNASKALKHVNDYFNTSYAPAEYYGSQTASKVIVTFGKSETVAARALLAANPDVGVLSIRIFPFVAENIFNVLPTTCKSLVVLSQVRSTAVGTSSIYYSFLLATLLSTKPSALAISEHRYSLVESVTLSSLFDALHETLQLKAATPKAVHVDKSINVWESDVGDSLVLSLVSAYRTDKSRSVAFRPLFDNLTLAGVRFTVAQVSTANAVLTDVVKDVDADITILTTDRLPLHYRVLAKAAEHSICLLQSSIAPDEATKKLPYEFIADALEKGVKLVLIDPKKFAIDASNLPLLVSFIQLVKPGLGVDEALAVLAKQNNLTDTNLKDAVDSLKQSLSFINLDASALKDREPSEKELPSTAKETSFAPNAVKTLDEDITPQSSNWQTVAKQIIFPEAYKKKDALRPDVSEKVFTVHVRANKRLTPAEYNRNIFHIEFDLGDSGLTYDIGEALGVYGVNNKTHVHDFIEEYGLDANELIHVPSIQHPGHWETRTVFQALCQNIDIFGKPTKKFHEQLLEFETDEKERADLQILISPAGAPDFKRRAEVDMLTYADVLKEFKHAKLTAAQIAQIVPVIKRREYSISSSQKKHNDSVHLLVVVVGWKDGMGRDRYGQCSHYLSNLKVGEPLCVAVKTSVMKLPTSPLKPIVMAGLGTGLAPFRAFLQFKEWQRMQGIESGDILLYLGSRTQREEYLYGEDWEAYHSANLLTHIGQAFSRDQPYKIYIQDVMRSTKDMLKKALMDEGGSFYLCGPTWPLPEITSVLEEVIQSSYDEPVDARKIIEQWKEERRFVIEVY
The following text describes a protein:
Function:
TIR-NB-LRR receptor-like protein that confers broad-spectrum resistance and full immunity to several races of the pathogen Albugo candida (white rust disease). Confers resistance to the biotrophic pathogens Pseudomonas syringae pv. tomato DC3000 and Hyaloperonospora arabidopsis isolate Noco2. May play a role in the response to UV stress.
Miscellaneous:
MISCELLANEOUS: The gain-of-function mutants adr2 (T-DNA tagging) are dwarf, develop HR-like lesions on leaves, express constitutively defense and antioxidant-related genes, and have increased resistance to biotrophic pathogens.
Subcellular Localization:
Cytoplasm.
Domain:
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MASSSSSPRNWRYNVFTSFHGPDVRIKFLSHLRQQFVYNGITMFDDNGIERSQIIAPALKKAIGESRVAIVLLSKNYASSSWCLDELLEILKCKEYIGQIVMTVFYEVDPSHVRKQTGDFGIAFKETCAHKTEEERSKWSQALTYVGNIAGEDFIHWKDEAKMIEKIARDVSTKINVTPCRDFDDMVGLERHLKEMVSLLDLDKEGVKMVGISGPAGIGKSTIAKALHSRHSSTFQHNCFVDNLWENYKICTGEHGVKLRLHEQFVSKILKQNGLELTHLSVIKDRLQDKKVLIILDDVESLAQLETLADMTWFGPGSRVIVTTENKEILQQHGIGDIYQVGYPSESEALTIFCLSAFKQASPPDGFMDLADEVVRICDKLPLALCVLGSSLLRKSQTDWEDELPRLRNCLDGIESVLKVGFESLNEKDQALFLYITVFFNYECADHVTLMLAKSNLNVRLGLKNLANRYLIHIDHDQKKRVVVHRLLRVMAIQVCTKQKPWKSQILVDAEKIAYVLEEATGNRSIKGVSFDTAEIDELMISPKAFEKMCNLLFLKVYDAGWHTGKRKLDIPEDIKFPRTIRLFHWDAYSGKRLPSSFFAENLVEVNMQDSELQKLWEGTQCLANLKKIDLSRSSCLTELPDLSNATNLEDLYVGSCTALVELPSSIGNLHKLAHIMMYSCESLEVIPSLINLTSLTFLNMNKCSRLRRFPDIPTSIEDVQVTGTTLEELPASLTHCSGLQTIKISGSVNLKIFYTELPVSVSHINISNSGIEWITEDCIKGLHNLHDLCLSGCKRLVSLPELPRSLKILQADDCDSLESLNGHLNTPNAELYFANCFKLDAEARRAIIQQSFVSGWALLPGLEVPPEFGHRARGNSLIIPYSASNRFKVCVVMSLNHHQPFELVPRNLLYRWTVIGDSVSSDEKTFHLSHMFNADSVNSKLQKPHLFIFHSCLPFIFHSCLPFIFDISNIMLEFSSEYKDFDILECGVQILTDETDERNIWGSLVF
The following text describes a protein:
Function:
Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP, so that uracil cannot be incorporated into DNA (Probable). The Ser-64 side chain changes its position upon ligand-binding to make contacts with the nucleotide phosphates.
Domain:
The uracil deoxyribose moiety interacts with the protein through Ile-81 and Tyr-85, which discriminate against the ribose form of the nucleotide.
Sequence:
MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLVPLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDTEIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK
The following text describes a protein:
Function:
Probable chromatin remodeling factor. Required for the initial establishment of DNA methylation and for accumulation of 24-nt siRNAs. May act on RNA templates by remodeling ribonucleoprotein structures and thereby influencing the availability of the RNA to polymerases.
Miscellaneous:
MISCELLANEOUS: Associates in vivo with Pol IV but not with Pol V.
Subcellular Localization:
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=In the nucleolus, localized in a ring around the inner periphery.
Sequence:
MKRKHYFEFNHPFNPCPFEVFCWGTWKAVEYLRIENGTMTMRLLENGQVLDDIKPFQRLRIRSRKATLIDCTSFLRPGIDVCVLYQRDEETPEPVWVDARVLSIERKPHESECLCTFHVSVYIDQGCIGLEKHRMNKVPVLVGLNEIAILQKFCKEQSLDRYYRWRYSEDCSSLVKTRLNLGKFLPDLTWLLVTSVLKNIVFQIRTVHEKMVYQIVTDEDCEGSSSSLSAMNITVEDGVVMSKVVLFNPAEDTCQDSDVKEEIEEEVMELRRSKRRSGRPERYGDSEIQPDSKDGWVRMMPYRYNIWNVSSDDDDEEEDCEDDKDTDDDLYLPLSHLLRKKGSKKGFSKDKQREIVLVDKTERKKRKKTEGFSRSCELSVIPFTPVFEPIPLEQFGLNANSLCGGVSGNLMDEIDKYRSKAAKYGKKKKKKIEMEEMESDLGWNGPIGNVVHKRNGPHSRIRSVSRETGVSEEPQIYKKRTLSAGAYNKLIDSYMSRIDSTIAAKDKATNVVEQWQGLKNPASFSIEAEERLSEEEEDDGETSENEILWREMELCLASSYILDDHEVRVDNEAFHKATCDCEHDYELNEEIGMCCRLCGHVGTEIKHVSAPFARHKKWTTETKQINEDDINTTIVNQDGVESHTFTIPVASSDMPSAEESDNVWSLIPQLKRKLHLHQKKAFEFLWKNLAGSVVPAMMDPSSDKIGGCVVSHTPGAGKTFLIIAFLASYLKIFPGKRPLVLAPKTTLYTWYKEFIKWEIPVPVHLLHGRRTYCMSKEKTIQFEGIPKPSQDVMHVLDCLDKIQKWHAQPSVLVMGYTSFLTLMREDSKFAHRKYMAKVLRESPGLLVLDEGHNPRSTKSRLRKALMKVDTDLRILLSGTLFQNNFCEYFNTLCLARPKFVHEVLVELDKKFQTNQAEQKAPHLLENRARKFFLDIIAKKIDTKVGDERLQGLNMLRNMTSGFIDNYEGSGSGSGDVLPGLQIYTLLMNSTDVQHKSLTKLQNIMSTYHGYPLELELLITLAAIHPWLVKTTTCCAKFFNPQELLEIEKLKHDAKKGSKVMFVLNLVFRVVKREKILIFCHNIAPIRLFLELFENVFRWKRGRELLTLTGDLELFERGRVIDKFEEPGGQSRVLLASITACAEGISLTAASRVIMLDSEWNPSKTKQAIARAFRPGQQKVVYVYQLLSRGTLEEDKYRRTTWKEWVSSMIFSEEFVEDPSQWQAEKIEDDVLREIVEEDKVKSFHMIMKNEKASTGG
The following text describes a protein:
Function:
Involved in pre-mRNA alternative splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFVRFHDRRDAQDAEAAMDGAELDGRELRVQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRSYGRRSRSPRRRHRSRSRGPSCSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEEEGQMSS
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MSDATLFLRKNKDKQRRRNVSGASRIASTSNSSLASRPGASKGQPVAGPSSSGAPSSAAPSPSSVSIKPEPDSSNNPNITEIKIFSTGSNSALRYNLMRLNSVKDVDPTQITAPVLMNRKKPGPKDPPTFALDENGKIVGRYVYDEEGKPILDEEGQPVVERKEVVDMSLVGQAPGGGRKKRVKRGTKEVFHQDIEIMRLRREEALPWVLESGNPQDKPAQPEQWVGRMLEQGQLSTVLLSNDGTRDGFEMMPLGRSYKFEPARPFKPLDSDAANKLFELQAKNKIHDRWAFRPADNQSGEASSASTPIQVKAEPNELEQRASRMETRIKMHKGVTVDRKAKVERYEDDYQREGHRVERGMEGGVDEELDFDEAEEFQDDDDNNTFYRDAQEEEEARELEERLKKEFRVANANVGDRPQIDAEDDEDDLFGDKSLDDEGKKLRKIMRRRMRENGEDYDIDDDSDSDSDDESTTSTQNKEKEKEKDKEKEKAKEKDSSRNPSQPPSRPSSRPPTARTSSPSGSNPRYPSPKKGKASTAPPPVSGASLIAQRATSRGASPRPSTHGGHVAGRASSPLGRVPSPAEGRGPGVTGQSQPASRATSPAVRESSPASGGAAATGGASPASGGPSTRDVSPAPPAGRPSPRKENAAVSTSSSSAKRKSSPSVSTPSADAPPRPKKHKKTGSLTPAPAPEDIPPFSGMITKQDVLGWFQRNKKKAVPMNEAIGAFRKRIVDAGPNRDANQKLFLGWIRMVADQENGNLSLKPEFRQ
The following text describes a protein:
Function:
May function as a general inhibitor of the histone deacetylase HDAC1.
Subcellular Localization:
Nucleus.
Sequence:
MLRKSKKQPQTVAEKVSKLLAHPNESDSAEDSDFDVATGPRLVDFEEEEYDLPDARSTDFRKRNVKLLSEQSDRYKGKISSRKELDDDEDKDDEQEVSYEESDEDDENLTNFKQKLNAGGAEDSEEETAAGHSESGEESEEIESNLTDFKKKFEAGDFKYDDDEEEDDDSEEEDHSQESEGDDDDSEDDEAEDDAIKPSDVMSKTNHQAEIQKGLAVQNQLRIWERLLELRINTQKFTSKANQLPAPETLTKLASESDELQSVLNEAQERSSKLLQQLLSLQSALHQQYSEMKKSVKRKQPTEDSGPAVKKFGSVLQSNFQQMIGYRNEVLLKWDDRTKLLTPGAGVKRKSLQEDYDIIKKIGSALANREALVEKSQTPKNSQAEQQENTPVQRLKHIYDDSDFYHQQLRELIEYKASTSSNMSEITKQFVELQKLRQKMKKKVDTRASKGRKLRYVVHNKLINFMAPNESSDWTDASKSELYKSLFV
The following text describes a protein:
Function:
Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes.
Subcellular Localization:
Nucleus.
Sequence:
MPGTDYAEDRIPRISLTEGLELNTQLFLEMQIKKMKEIIPQLYTDQVNDKNNSLTTSPKQLANEHVSQPNGHESQSHGYQDSKAEDDKMCMVTCLRCRSLQKVPLQELKKDNQYSQIEDQMFFVCVKCTFGVSPPIPFMNDMPGSIDSGNKDATISRTITNQFKVKNFQPGKYYCDKCRFSTKDPLQYKKHTLQHEEIKFFCSHCSYVSYTKGEFQRHLVKHTGTFPYQCEYCDYGAVRNDYIVKHTRRVHETSGEKRPLRQVMEHQPKRTNFSKQNSEVLVNEVSKSNSFLNEPTDSPLYFPSHGDQDKTGPAISLPETKECSRDEAASAPDKACLPEPSKVNLFENENVEVELLSPAKEPVQPGMPLTVVAPAELRVPENCLAQLIDVKVVNGTQQLVLKLIPMKEKNGFKLGSSDEGKYEPMNKYTVPNEQEKLVPTEPTPPAMEGSPEKPLGINNLHSTDYTHAKDLDCIKSSDSQVLKNMSITNQCESCPNNDRVGNWRQEVLSFPYRTALSPVSSRDGHIEQNNFSSLSVMNNGTLCSPVKRLSVLPTVAALSPCQERSQNHLEKPSSNSKPTEALVALAKRDTLPVNQEASLNKKEVDTFKMVAFSEKLNQAQAKEPSGDPNSMQDSTLCRSEQSHINLIRENDIKTQDPEEVMSEDLVGVALQNSGSNITSSDGPVISSVFSLSSGVENIPEGIKWDNACFRTKSFNSLQKKIAQLIAATESSKTSLSPSSTVEQQSLPLETPLDCIQGHNAPSIDRVPPQALQNNATGIELLINEQMQHHNNVDEQTKAREVTDNHDAVSVFIPKDTGLKAFSSTENEHLVENKLPNGGNKRELSKSVSFNFLEQIGEDLSLTNESQLIDSSRNFGTSLGNKPNQEYTTSTVSKKSDSSCPQTKEDNNQDKQEKLTFSGPSGSKINTKQALISKKKNKIISDSSHMLPDVCIFMTARHLRLIPLKTEQLIKCPRRNQPVVVLNHPDVDSVEVINVMKVVHKYKGNVLKVVLSERTCDQLGIKRHHRRLIYQNLEAVCPVKKTMLKMKLKKIHKNSYQVQSMEAPIWAVSMNDRDVDIQESRPDVAQQQQLEEQASGTAAEWKQQ
The following text describes a protein:
Function:
Transposase-derived protein that may have nuclease activity (Probable). Antagonist of polycomb-group (PcG) protein-mediated chromatin silencing, probably by preventing the association of POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) with its accessory components. Needed for full reactivation of several floral homeotic genes that are repressed by PcG.
Subcellular Localization:
Nucleus.
Sequence:
MAPVKQKKKNKKKPLDKAKKLAKNKEKKRVNAVPLDPEAIDCDWWDTFWLRNSSPSVPSDEDYAFKHFFRASKTTFSYICSLVREDLISRPPSGLINIEGRLLSVEKQVAIALRRLASGDSQVSVGAAFGVGQSTVSQVTWRFIEALEERAKHHLRWPDSDRIEEIKSKFEEMYGLPNCCGAIDTTHIIMTLPAVQASDDWCDQEKNYSMFLQGVFDHEMRFLNMVTGWPGGMTVSKLLKFSGFFKLCENAQILDGNPKTLSQGAQIREYVVGGISYPLLPWLITPHDSDHPSDSMVAFNERHEKVRSVAATAFQQLKGSWRILSKVMWRPDRRKLPSIILVCCLLHNIIIDCGDYLQEDVPLSGHHDSGYADRYCKQTEPLGSELRGCLTEHLLR
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Also has weak Li(+)/H(+) antiport activity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLDLVAAFIALTTLLTYVNYRFIRLPPTIGVMATALVFSLIVQGLSELGYPILEVEMQEIIRRIDFSEVLMTWFLPALLFAGALHVDLSDLRSYKWPIGLLATAGVLIATFVIGGLAYYTFPLFGWQVDFIYCLLFGALISPTDPIAVLGILKSAGAPKPLATTIVGESLFNDGTAVVVFAIILGILQLGEAPTVSATAILFVQEAIGGVVFGAVLGYGVFVMMRGIDQYQVEVMLTLALVIGGAALAARLHVSAPIAMVVAGLIIGNHGRHYAMSDETRRYVDKFWELIDEILNALLFALIGLELLLLPFSWLHVAAAFALGGAVLVSRLLTVGPAILVLRRFRGANRQVPAGTIRILVWGGLRGGVSVALALSLPLGPERDLILSLTYIVVLVSILLQGLSIGPLVRRIYAGQPLEKSEGAH
The following text describes a protein:
Function:
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).
Subcellular Localization:
Nucleus. Note=Localized with DDX1 in cleavage bodies.
Sequence:
MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQTVHSAGPGSGSSVSMNQQNPQTPQAQTLSGMHVNGAPPLMQASLQAGVAAPGQIPATVTGPGPGSLAPAGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGPLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHDSRGPPPHEMRGGPLTEPRPLMAEPRGPMIDQRGPPLDGRGGRDPRGIDARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARSMDTRGPVPGPRGPMPSGIQGPSPINMGAVGPQGSRQVPVMQGAGMQGASIQGGGQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
The following text describes a protein:
Function:
Required for aluminum (Al) resistance/tolerance, probably by translocating Al from sensitive tissues such as growing roots to tissues less sensisitive to the toxic effects of Al.
Miscellaneous:
MISCELLANEOUS: ALS3 transcripts are mobile in the phloem sap.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDLKWDDFFNDYEWLIVFLKGMVKPAAALVVVLLAVILSYSQNLSLEGEMIYSVSRSFLQLSVIGFVLQFIFNQENSGWIILAYLFMVSVAGYTAGQRARHVPRGKYVAGLSILAGTSITMFLLVLLNVFPFTPRYMIPIAGMLVGNAMTVTGVTMKQLRDDIKMQLNLVETALALGATPRQATLQQVKRALVISLSPVLDSCKTVGLISLPGAMTGMIMGGASPLEAIQLQIVVMNMMVGAATVSSITSTYLCWPSFFTKAYQLQTHVFSSD