lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MKVYDDEDNIGVLEQTIFPDKGVLYQQRIVCAEQKINLVQCRLFLTKLIAVFNRGDTFTQEEATELFFATTKLFYSPNVPLRQLLFTALRSVIPYACDVFVVMNSLSKDATSTYDFQRSSALRTLGMILTDQTINSLERHYKQGIVDKIPNVSVSALSTACKLALTHADVVAKWMPEISTALSSSNHLVQYQAIRLLHILKKHDRVALIRCVVTYGKEKPLRSPYAHVELLKICKDILIGERAFSKTVLPLVEYIQTSMRPNNDLVALEAIKLASQLELDAAPQSLSAQLMNSIQVYLQSNKTILRFEAIRVVSEMSYRYNELVSTVRIDVESLLRESNRAILTLAIATSLNICNESSIDGLLNKVAKFMSELPDSFRTKVVNTVEKLAERYPSKYLTLLSFLSHSLTIKGVKFQTAVVNTIRRLCIIQPRCRETSLTTLADYIEDCEYPEIIMKVFSFIGEEGPHSKKPMKYIRSIYNRLLLESPIIRAAGITTLSKFAEIPELKPNIIEILKKCAYDEDQEVRDRACFYSVFLDTPKVETPVITSQTDIDALQHVLEQYINGDCETPFDLEEESKKTIIIEPIKEEEVSNEVKKEQEIIEGFGEVIKKSEVTLTTTGSEYDVVCKKMIYKNNVVLLYSITNTLTDYCLSNVSIEIGIEKGDYKIIEQSTISSLPAQGSDIIKVVLDRPDSLIGTFSNKLIYTLKENIEDDTGDEDEYIIDNVSLNLSDFVSPVEIEDWNVQFESLSKEANKTQIFKFPAFKNLQIAVDKLKELFGLNVINGSDDAKKAVKKHVLLLAGNILLKEPATTFIRLRMLCDEKGVTVEVCIRSTNTLIPDMLLALL
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MNKMLSNDCLGTQEPHTFCKTTETLEHSHLQEITLDKTAAGSTLISHQNVCCIAELSGENTEIMEISLLHNESDAGSTSLLPLPLLSYGPRSMVPIQVPPSSDFESILSPEPIYSDLQLKEMNYNAAAMDESTEFLHLILSGNDEGYNSTTELQVWDVVDFYVSENFSALQFDSLMGFTNEVSTSYNDCMNLVDMVERPVARLSLDDTPKPSNSDDAVPADNVTMDPDETSLYLQTKPTDSETESSSAAGDVETEYLDLKLLSRCMPDLMDVDSPNCLSKTPVKKKHVTLVLDLDETLVHSTLDHCDNADFTLEVFFNMKNHTVYVRKRPYLKMFLEKVAQMFEVVIFTASQRVYAEQLIDKLDPDGKYISRRIYRESCVFSDGCYTKDLTILGIDLAKVAIVDNTPQVFQLQVDNGIPIKSWFDDPSDQELIELLPFLESLVDSEDVRPIISKTFHDKLEQN
The following text describes a protein:
Function:
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MVLESIARIIKVQLPAYLKRLPLPETVGGFAKLTVSEWLRLLPLLGILALLGYLTIRPFLPKKKKQKDSLINLKIQKENPKVVNEIDIEDLKSTNACYCRCWRSKTSYLLIHFGSLGVLHLITRLRRDSSVRAFPVCDKSHIKHNELTGDNVGPLILKKKVL
The following text describes a protein:
Function:
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Sequence:
MSEAPAVMSAEQLLREAVIRIARSDAEPLLLHALGRDRAWLFAHGRDPVPAEQAQRFGALVERRHQGEPVAYLTGSRGFWTLDLAVSTATLIPRADTETLVELALERLELTAGVRVVDLGTGSGAIALAIASERPQAQLIATDASADALAIARHNAHAHGLHNVECRLGHWLQPLAGERFDLIASNPPYIAAADPHLQQGDLRYEPASALASGSDGLDDIRLIVADTPAHLLAGGWLLLEHGWDQGEAVAALLIARGFAAVATHQDLEQRDRVTLGQWPHAAG
The following text describes a protein:
Function:
May have regulatory role in cell division or differentiation in response to extracellular signals.
Sequence:
MENLQSKFSLVQGSNKKLNGMEDDGSPPVKKMMTDIHANGKTLTKVKKEHLDDYGDASVEPDGEHAKRNRVSLPETLNLNPSLKHTLAQFHLSSQSSLGGPAAFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRNGKRIQSKTDTPSGMELPSWYPVIKQEGDHVPQTHSFLHPSYYLYMCDKVVAPNVSLTSAASQSKEATKAETSKSTSKQSEKPHESSQHQKTVSYPDVSLEEQEKMDLKTSRELYSCLDSSISNNSTSRKKSESAVCSLVRGTSKRDSEDSSPLLVRDGEDDKGKIMEDVMRTYVRQQEKLNSILQRKQQLQMEVEMLSSSKAMKELTEEQQNLQKELESLQSEHAQRMEEFYIEQRDLEKKLEQVMQQKCTCDSTLEKDREAEYAAQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQIGKSSKPSKD
The following text describes a protein:
Function:
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MKIMVAIKRVVDYAVKIRVKPDKSGVETKNVKMSMNPFCEIALEEALRVKELGLASEVVAVSVGPSQFTETLRTGLAMGADRAIHVEAPENIYPITIAKILKALVDVEKPGLLFLGKQAIDNDQNQTGQMVAGLLKWPQGTFASKVVLDKEKQVATVDREVDGGIETLCLNLPAVITTDLRLNQPRYATLPNIMKAKSKPIKKFTLQDLNIEIKSDLEVVEVTEPPKRKSGVIVSSVDELIDKLKNEARVI
The following text describes a protein:
Function:
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.
Subcellular Localization:
Bud. Bud neck.
Sequence:
MSYAGQSSKASSSLDPRSIRTASSSAYPNHAGVGTHHDSEVAFAELQMLSQNQRKLATLTGRMTTILSGFDKRLIKLEGSILPIHKGTQKLARMSDNIDLTLSALNKTLGHYDVVIDEQPLLKQGPDASDTRPYMDTIDRVIKGLDYLQKSNLKSQEGVMKRMNDLIELGARNLCTVISDWVRADSEAIDLSEYSRNAHYPVLSETTHNAIVPIFNYLSTLPQHPRTGFAPMSAGLAVYASVRGDYLKQCLAPLAARLQQHALEQIGTGVTGAGMVMVTQDDDFDSHSNYRRGQAGAVELFEAYYGMLDNDYRILQGLMTSAELDKQTLLLASTFSQLASQPLTALIESLGTVQSHVRRHLATHTSFLLDLIGALSGIVLTGRWDVLLRAMEDSPEAPLHSTSPIDRAELDLNTGFAPAAEVLEIYSKLKNTAIGIFPRFIEDVKAIPARKVSEVPSTSVNEITYLGLQFIRQITEYSDVVSPLLHTLGNGNWMMSSGVAPILSLGLDSDASKQSIVGDYLNDVVAVVLTSLEARSRAIRQPSTASVFLLNNIGHLRRSVSAPLPSYLGAAEDGSSVSIISLHLGEMGNDLLGTALRQANTSYLDAWSPVVAPLMDDQPLNATQYHRHATSKLIGVGSGSEKNQVKDRFARFYEALEDLERLHRAYPVNREDHELKERLTRDVTRLVCPMYARFLAKHKASDFTKNPSKHIRMTEQEVEDKIASLFC
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MNPQDAPQQDLIYRDFLERFLSNIDIAQIEAMRQQNKIRFPINLDLLRSESRQQYPNLVDDLIRNPTDFIRVFQQKLCQICKQLQDQQEDDDKKGVQTDKTYKIYFEGKLGKNYVTPRGLGAAQINQLVCTQAIVTKMSLVLLKLSKSVHFIEKKNQFKQVEYFNNMDPSARTSARQVRVVQKKDEEGNPMIFEFGLSDLNDMQTLVVQELPERTPTGMLPRSLEVILDQDLVDRVKPGDRVEITGVYKCIPNSTTKANGTFRTTLIAQNIKVMNAVQETKISEIDIRHIKEIAKKSNLLEYMSKSIAPSIFGHGIVKQSILLQLLGGTEKNLETGTHLRGDINVLLIGDPSTAKSQLLRYVMGTAPLVVTTTGRGTSSVGLTAAVKRDNETGENTLEAGAMVLADGGVILIDEFDKMNEIDRVAIHEVMEQQTVTIAKAGIHCSLNARCSVLAAANPLYGEYQQDMAPTKNIGLPDSLLSRFDLLFIILDEKKKDIDRKVAERVTKNHRYKGQYDDEENIGDIIQPMAQMSIKQEISPFVQQSAIYHSNDQKDLLTQSFLKKYIMYAKENYPNVVLDDEAAEEVTRQWTKMRQNDLLEKQIRTQPITIRSLESLIRLASAHAKLRLSNVVTKQDVKIGAKLMKISLQMDQEDEVEDNKKPSGRKSSLQRLKSEQPLSAGRQKLESEQLKQEEQENQLIVKSDKKKQKQDDPKEKEAEFHLFLQQAHSQNITRDQLKAVHKVLRDFKEKLHQDVVDIDIIWGELQSQSRIIIADYLQFLKCLLELDKQEKVQFDDKKRTVQLL
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MDERECLEEKLDFGFAFDSKNFSDRKLHIHIIEELNSSDAESEGEGESKGNDQDDGKDVDNQSFPDICETFETQDGEIFLVTEGDDEYDKFKGEDMIIKPDLHLDMEYKHVLRVEKVYINSAILAANSPFFYKLFSNGMKESVQQHVTLCVYESEEDALIDILRYIYTGKLTSTSASELLTVLIIADRFEVFSCMGYCSRLLCKLPMTLEFAINSLELPCSVSIATSVQPLIDAAKEYLVDRYMNILKCQDELMELPLAAIQSILSSDDLYVASEDVLYDVIVKWVRLKYPIVAERRQVFCTYLCPLIRFPMMSCRKLKKVLRCSELFSEFATKVVLEALFFKADAPHKQRALAQAETLSHRFIERGYKYRPVKIVEFQSPLKQCIVYLNLHRSECSKLFPSGRIYSQAFHIDGQAFFLSAHCNMDQENMFHCFGLFIGMQDKNASALTVDYEFAARTKEEDHEDFVSKYKGYYTFTGGKAVGYRNLFTTQWSKFLSEDSPYFINDVVHLRAELTIKRT
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MLTEEWYELEGWTQDICGIISIVNNLFLMYLILIKSPVALGSYKWLMMFTTCFELAYALVNLIAGSSVRTFGSAWIVFQKSRYRHEITLFLIVVYCACFGFSLAIIACHFVFRYGSVELEFRNKYLSGYKQIFLYVFPFFISIVWGIICWVYCGETPQRTDYLRNKMMDNYHLKIEDVGYVSSYYWPVDENGQVHPDFDSFFGTSLMWVIVGISVMSVLYFGIGCYTWISKKLEFMSSQSVAMKSLQKQLFNALVVQSAIPFILMYVPIGMAFVFPMLNIELNLKYPFISLTVAIYPAIDPLPSILIIASYRKACIDMIRSLKCWGDKGKVTANNTRVDSIAMFTIK
The following text describes a protein:
Function:
Protein-lysine N-trimethyltransferase that specifically catalyzes trimethylation of 'Lys-22' of the RPL40/eL40 subunit of the 60S ribosome, thereby promoting translation elongation and protein synthesis (By similarity). May also act as a histone methyltransferase in the context of histone octamers, but not on nucleosome substrates: trimethylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 to form H3K36me3 and H4K20me3, respectively. The histone methyltransferase activity, which is independent of its SET domain, is however unsure in vivo (By similarity). In association with the NCoR corepressor complex, involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages, possibly by catalyzing the formation of H4K20me3 at the gene promoters. Plays an important role in embryonic stem (ES) cell self-renewal and differentiation. Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by promoting H4K20me3 marks. Acts as a regulator of the hypothermia response: its degradation in response to mild hypothermia relieves the formation of H3K36me3 at gene promoters, allowing expression of the neuroprotective gene SP1.
Subcellular Localization:
Cytoplasm.
Sequence:
MAASMCDVFSFCVGVADRARGSVEVRYVDSIKGKGLFATQLIRKGETIFIERPLVAAQFLWNALYQYRACDHCLRALEKAEENAQRLTGKPSQILPHPELCSVRKDLHQNCPHCQVMYCSAECRLAAAEQYHQILCPGPSHDPRHPLNKLQEAWRSVHYPPETASIMLMARMVATVKQAKDKDHWVRLFNHFCSRTANQEQAIVHKLLKGKFKDQLELLLGLFKEALYEEALSLWFTPEGFRSLFALVGTNGQGIGTSSLSQWVHACDALELTPQDREQLDTFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFVLHVTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFNCSCPKCLAEADDPNVTSEEEEEEDEEEGEPEDAELGDEMTDV
The following text describes a protein:
Function:
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MLTIPFLSNYIEKVVTKQLLADNVDTLNYYVTSLLLAFFSFAISCKQYFGTPIQCWVPNEFKGGWEKYAEDYCFISNSYHVPMDEQIQDHHRGDHISYYRWVPIVLALQAVFFFLPNYLWNLMSNNTAFNPRHYVEEASKLKTLTGVAREKEIDALADQFMEGVAVFGRDEYAPRSVFARSGWNCTYLYLLTKALYVLNVVGQMCILNAFLGGTYWSWGADVIGDMLTGREWQEAEVFPRVILCDFSVRAMAQKHTYTVQCVIMMNMINEKLYLFIYLWFIFLIALTLANFFYYLVSLSVPSLRTRLVFCSMDGKRLRLSRRESARFALDCLHPDGVLLIIFIREHVGGRVANELTQKLIQKHYANGSSVSSRSSDGDHCTMESLEKKPFISGMPLTHFDRYDPPPKNHQMSAPKYPHISPNHTMNQTMESAPPVDEFDRYTTMRMDDRSILPRPSPRTTHQGTVLDHTDHPAARNSSPTDV
The following text describes a protein:
Function:
Positively regulates a late step in synaptic vesicle exocytosis.
Sequence:
MDMMGKAMFSHQVGKFKEDLGLKGDEEEKTSNYDPRKEAEEEEQLAEQRQRRKEAQGKKQAERAVNRNKIREKYGLKQNKHDQQLVTNHGKPNPSAKEPSRDDSSLTRSGSSSSSQDKKDDKCAVM
The following text describes a protein:
Function:
Mitogen-activated protein kinase (MAPK) involved in the transduction of signal between the host cell surface chitin receptor complex CERK1-LYK5 and the intracellular MAPK cascade that leads to chitin-induced immunity. Phosphorylates and activates MAPK targets (e.g. MKK4, MKK5, and possibly MKK2) when phosphorylated by PBL27 after elicitation by chitin. Required for resistance to the fungus A.brassicicola.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol.
Sequence:
MRWLPQISFSSPSSSPSSSLKPVASYSESPDPDRNQDRDRFHRRLFRFNRGRLTRQRKLRHLTDDDVLLGERRASTSSSTFDSGLTRSPSAFTAVPRSPSAVPLPLPLPLPEVAGIRNAANARGLDDRDRDPERLISDRTSSGPPLTSVNGGFARDSRKATENSSYQDFSPRNRNGYWVNIPTMSAPTSPYMSPVPSPQRKSTGHDLPFFYLPPKSNQAWSAPDMPLDTSGLPPPAFYDITAFSTDNSPIHSPQPRSPRKQIRSPQPSRPSSPLHSVDSSAPPRDSVSSPLHPRLSTDVTNGRRDCCNVHPLPLPPGATCSSSSAASVPSPQAPLKLDSFPMNSQWKKGKLIGRGTFGSVYVASNSETGALCAMKEVELFPDDPKSAECIKQLEQEIKLLSNLQHPNIVQYFGSETVEDRFFIYLEYVHPGSINKYIRDHCGTMTESVVRNFTRHILSGLAYLHNKKTVHRDIKGANLLVDASGVVKLADFGMAKHLTGQRADLSLKGSPYWMAPELMQAVMQKDSNPDLAFAVDIWSLGCTIIEMFTGKPPWSEFEGAAAMFKVMRDSPPIPESMSPEGKDFLRLCFQRNPAERPTASMLLEHRFLKNSLQPTSPSNSDVSQLFNGMNITEPSSRREKPNFKLDQVPRARNMTSSESESGQQQQQQQYRSPDLTGTVNRLSPRSTLEAIPSPCPSQRPKPSSSDRRRTGVTSDHL
The following text describes a protein:
Function:
Forms the phage's tail tube composed of 32 hexameric disks. When it encounters the appropriate initiation complex gpM and gpL, it assembles in hexameric rings that stack on top of each others. Multimerization ceases when the correct tail length is achieved through a mechanism dependent on tail terminator protein.
Subcellular Localization:
Virion. Host cytoplasm.
Sequence:
MPVPNPTMPVKGAGTTLWVYKGSGDPYANPLSDVDWSRLAKVKDLTPGELTAESYDDSYLDDEDADWTATGQGQKSAGDTSFTLAWMPGEQGQQALLAWFNEGDTRAYKIRFPNGTVDVFRGWVSSIGKAVTAKEVITRTVKVTNVGRPSMAEDRSTVTAATGMTVTPASTSVVKGQSTTLTVAFQPEGVTDKSFRAVSADKTKATVSVSGMTITVNGVAAGKVNIPVVSGNGEFAAVAEITVTAS
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAWKLFVFFLLFHVFSVFVVVLAASPPENVTIGALLALRTRIGRAARVAIQLAVKEINEDQTLLNGTRLLVQISDDNCNAVQGAAAAVELMQRNRVVAIAGPQTSEVAHFVAHMGTVTKIPIVSFSATDPTLSESQYPFFIRNTHSDRIQMEAIADFVKLFEWKEVVALYSDDNFGTNGIMELHDELSKVGATIPFRAAVSRSMNKDDIGEILAKFGDAGGRIFVVHTDASVGRAVLTEAYDLRMLTTGFVWIVTETLSSVLDGVYSDDEFVAAAQGIVGTRSFIPGSPQLERFKSSWRSFNVNRTRGGYRSSNVNLYGLYAYDTIWMIAYAIDGFLAANGSFEYEAMKCPPGGERRLDLARLSVAKFGARVLREIVKTKFSGISGKVELSAGGELKGSDLEVVNMYGRGLRTVGYWNKGTGFSVDAPSEDRPQMESVSRLQKKLHHIVWPGDNLHVPRGLMIPKTGRELVIGVPLKQGYKEFVDLTIDVSNVSTFHGFCIDVFKAALSSLPYTVTYSFVGFGDGNSTPSYDELVEKVANKKFDAAVGDITITRKRAKLVDFTQPYTISGLVLVVPVTETHAHQAWAFLQPFSNSMWYTTAAFFFFTGTVVWILERDKNRDFGGRPRKQVVTTFWFIFSTLFFSQRERINSILGRIVVIIWLFVVLILISSYTASLTSILTVRRLRPTIQGLSRLVGSDVRIGYQEGSFVKDYLLQLNVESDRLVPLKSIATYSTALSSNEVGAVVDELPYVQLLLSSDCRFAISGEEEFSKSGWGFAFPKGSALAADVSTAVLTLAETGELQRIHETWLHTTRCSGKVVEVKFDKLDLRAFSGLFGFFAVVVVVATLSHALRSYCQNYKTALLAAAPFQWPSHFSRGSRFVRSFRSYVWQTGKNVSVA
The following text describes a protein:
Function:
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity).
Subcellular Localization:
Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
Domain:
The PXY motifs are required for binding WW domains. PXY1 is required to promote transactivation of beta-globin and for hyperacetylation of histone H3, but not for binding to the HS2 promoter site.
Sequence:
MPPCPPQPNRNRLPQLPTGELGEMELTWQEIMSITELQGLNVPSEPSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFTLPPPPYELPASTPHAPDLPYSYGNIAIPVSKPLTLSGLLNEPLPDPLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVDMYPVEYPYSLMPNSLAHPNYTLPPTETPLVLESSSGPVRAKPAVRGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTELYHDIFQHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD
The following text describes a protein:
Function:
Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin. Hydrolyzes polyubiquitinated 'Lys-63' polyubiquitin chains in RPO21, producing mono-ubiquitinated RNA polymerase II. Removes ubiquitin chains that initiate proteolysis of FZO1 and inhibit mitochondrial fusion.
Miscellaneous:
MISCELLANEOUS: Present with 2420 molecules/cell in log phase SD medium.
Sequence:
MPNEDNELQKAIENHHNQLLNQDKENADRNGSVIEDLPLYGTSINQQSTPGDVDDGKHLLYPDIATNLPLKTSDRLLDDILCDTIFLNSTDPKVMQKGLQSRGILKESMLSYSTFRSSIRPNCLGSLTDQVVFQTKSEYDSISCPKYNKIHVFQAVIFNPSLAEQQISTFDDIVKIPIYHLKVSVKVRQELERLKKHVGVTQFHSLDHLHEYDRVDLSTFDSSDPNLLDYGIYVSDDTNKLILIEIFKPEFNSPEEHESFTADAIKKRYNAMCVKNESLDKSETPSQVDCFYTLFKIFKGPLTRKSKAEPTKTIDSGNLALNTHLNPEWLTSKYGFQASSEIDEETNEIFTEYVPPDMVDYVNDLETRKIRESFVRKCLQLIFWGQLSTSLLAPNSPLKNTKSVKGMSSLQTSFSTLPWFHLLGESRARILLNSNEQTHSPLDAEPHFINLSVSHYYTDRDIIRNYESLSSLDPENIGLYFDALTYIANRKGAYQLIAYCGKQDIIGQEALENALLMFKINPKECNISELNEATLLSIYKYETSNKSQVTSNHLTNLKNALRLLAKYTKSDKLKFYVDHEPYRALSQAYDTLSIDESVDEDIIKTAYSVKINDSPGLKLDCDRALYTIAISKRSLDLFNFLTEECPQFSNYYGPEKLDYQEALKLLQVNENASDETILKIFKQKWFDENVYEPDQFLILRAALTKISIERNSTLITNFLLTGTIDPNSLPPENWPTGINNIGNTCYLNSLLQYYFSIAPLRRYVLEYQKTVENFNDHLSNSGHIRRIGGREISRGEVERSIQFIYQLRNLFYAMVHTRERCVTPSKELAYLAFAPSNVEVEFEVEGNKVVDQTGVLSDSKKETTDDAFTTKIKDTSLIDLEMEDGLNGDVGTDANRKKNESNDAEVSENEDTTGLTSPTRVAKISSDQLENALEMGRQQDVTECIGNVLFQIESGSEPIRYDEDNEQYDLVKQLFYGTTKQSIVPLSATNKVRTKVERFLSLLINIGDHPKDIYDAFDSYFKDEYLTMEEYGDVIRTVAVTTFPTILQVQIQRVYYDRERLMPFKSIEPLPFKEVIYMDRYADTENPLLLAKKKETEEMKQKLKVMKNRQRELLSRDDSGLTRKDAFLESIKLLESDTIKKTPLKIEAANDVIKTLRNNVQNIDNELMKLYNDINSLEEKISHQFDDFKEYGYSLFSVFIHRGEASYGHYWIYIKDRNRNGIWRKYNDETISEVQEEEVFNFNEGNTATPYFLVYVKQGQEGDIEPLKRILK
The following text describes a protein:
Function:
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.
Sequence:
MTRFTDTLWSSITDIYQAIIYHPFNEELARGILPREKFAFYMQQDALYLADFARALAIMAGRAPDEAAIIQFVRFAEGVAVVERALHHTYFREFGIETPTRQPAPACFTYTNFLLATAACRSYEEGMAALLPCFWIYREVGHDIYRRAAPNNPYQKWIDTYAGQEFDEVVTQAIALTDTIAEQASATQQQRMRDAFIYSARLEWMFWDSAYRLEQWLP
The following text describes a protein:
Function:
Catalyzes the attachment of glycine to tRNA(Gly).
Subcellular Localization:
Cytoplasm.
Sequence:
MTKDMETIVSLAKHRGFVFPGSDIYGGLSNTWDYGPLGVELKNNVKKAWWQKFITQSPYNVGIDAAILMNPKTWEASGHLGNFNDPMIDNKDSKIRYRADKIIEDYMLNEKGDENFVADGLSFDEMKRIIDEEGIVCPVSGTANWTDIRQFNLMFKTFQGVTEDSTNEIFLRPETAQGIFVNYKNVQRTMRKKLPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFCKPGEEIEWQNYWKTFASQWLKDLNLSEEATRLRDHDADELSHYSNATTDIEYRFPFGWGELWGIASRTDFDLKKHSEHSGEDFQYHDQETGEKYIPYCIEPSLGADRVTLAFLCDAYDEEGVEGSKDSRTVLHFHPALAPYKAAVLPLSKKLSGDAIKVFEELSADFAIDFDESQSIGKRYRRQDEIGTPYCITFDFDSLEDEKVTVRDRDTMEQVRMPITELKSFLAEKVKF
The following text describes a protein:
Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
MEREMAASYEPKLNSEIRIFESSDEIVTDLAEYISQVSEISVKERGYFAIALSGGPLVSFLRKLCEVPYNKTLDWSKWYIFWSDERAVAKNHADSNYKLTKEEFLSKVPILSGHVYSINDGATVEDAATDYEFVIRQLVKIRTIGVSESNDCPKFDLILLSMGSDGHVASLFPNHQALELKDDWVTYITDSPQPPPERITFTLPVINSASNIAILATGVDKANAVHSAVSDSSDGLDAAAPLPARMVQPTDGKLVWFLDKAAASSLEALSDDAYQQQHL
The following text describes a protein:
Function:
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRYIALDIGDVRIGVARSDIMGIIASPLETINRKKVKSVKRIAEICKENDTNLVVVGIPKSLDGEEKRQAEKVREYIEKLKKEIENLEIIEVDERFSTVIADNILKELNKNGAIEKRKVVDKVAASIILQTYLDMKK
The following text describes a protein:
Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
Sequence:
MKYVLVTGGVVSGLGKGVTASSIGVVLKACGLGVTSIKIDPYLNTDAGTMSPFEHGEVFVLDDGGEVDLDLGNYERFLDVTLTKDNNITTGKIYQSVLDKERKGDYLGKTVQVVPHITDAIKDWIESVSLIPVDGKEGQADVCVIELGGTVGDIESMPFIEALRQLSFSVGPDNFCLIHVSLIPVLGVVGEQKTKPTQHTVRELRALGLTPHFLACRSAQPLLESTKAKLSQFCHVAAANILNIHDVPNIWHVPLLLRNQNAHHSILKQLNLTNVATAPDLDSWNKMAETFDNLTNHVQIAMVGKYIGLTDSYLSVVKALLHACIACSLKPHIEWIAASDLEDESEKSTPEAHAAAWKILKSAECILVPGGFGDRGVSGMVLAAKYARENKIPYLGICLGMQIAVIEFARSVLGLERANSTEFDAQTSDPVVIFMPEGSRTHMGSTMRLGSRRTHLHNRDSLTSKL
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTHSLKPWNTFGIDHCAKHIVCAENEQQLLSAWQQATREGLPVMILGEGSNVLFLENYAGTVILNRLKGIEVNETADAWHLHVGAGENWHQLVRYALDNNMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCDYVDCVELETGKRLRLSAAECRFGYRDSIFKNEYQDRVAIVAVGLRLSKQWQPVLTYGDLTCLDPKTVTAQQVFDAVCHMRTTKLPDPKVNGNAGSFFKNPVVAADIAMELLERFPNAPHYPQADGSVKLAAGWLIDQCQLKGVTIGGAAVHRQQALVLINANDATSKDVVALAHHVRQKVGEKFNVWLEPEVRFIGRSGEVNAVESIA
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNSYLLAFKSGFGFLTTIPVGISMEGIDELMKKIYFYPVVGAVLGLLIGAIAYIGQLIFPDPVLAALIMGSVYYFTGFNHLDGVTDMGDGFMAHGSHEKKIKALKDTTLGTGGVAFGMLVLLAFYGSIRSIQDEGINVFGSNLPLLMFASMFIAEVSAKQSMLTIAAFGKPLPRPENQAYPGLGEMTINGATRKNFLIGFIFGAFVCFLPFGLIGLIPYLAACISALVLLNRSYAHFGGLNGDGIGTANEIGRITALIIIAVTLELSLNTGGLEWTLL
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDARLTVLTAFPPAAGIDNEEYYQNSQQHAKRVRELVRDNAQWIRESADDILKHVNPAVYSLSYLMILEFLLQSPGWTSQQAHESLASYMAQFFLQFDARQIRCKGSTWSDVLKEAYSERGLFPASVAVELVTAALLRLDPSGSIITSHHCNLVELAYNTGNVGALLPLIEKPIIYMPAKGMSTAQPLCDMSLPPPAYINPDSQLTDALTSAAVLQYDFLCGLCFIERRMWQQAFDAFERCVTYPTRDGGCSKIMTEAYNKWILVGLLLTGKPPTLPETTSQAAKKIFATQGKPYKLFAQAFKSETAGDLVREFEVINSELLPNEGNVELAKLVLAHYQRWQIINLRNIYTNISLEKIQERTQSAETGAPLPTVEAVDQLVQSMIADGSLQGAIERPKDGSPAYLTFLSSPAQGMSEVEFSAQVNKVMQGIKALEPIIEATNKRLASNREYISHTVKRQFDAAREHKLGLQSAGGGFEESSFHIEEEEDLMSGLPAH
The following text describes a protein:
Function:
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Sequence:
MIKYLSAHLRLARHDKPIGALLLHIPCVWGTILGQPTFNFQEIIWYSSVFGVGSFTMRAAGCVVNDMWDRNIDNKVERTRQRPLASGELQMKDAWISLFAHCSVGLLVLTQLSWSTIAASFGIVPIAFLYPLAKRYFSYPQLVLGIAFNWGVVVGGLQLAGMLNPTIMLGYAAGIVNTLIYDTVYGHQDKEYDKSLGLYSTAYTLPKNTPLYLTWVFSGLIGLTCYAASYHPGVYPLIVLNQLDMYLRLKATDFDNPESCGKFFRDFKWFQITIALIFGAGSYMKQ