lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Major facilitator transporter that contributes to the maintenance of intracellular siderophore ferricrocin (FC) levels. Plays a role in conidiation and confers protection against oxidative stress. Also contributes to fungal virulence in the Galleria mellonella animal model system. Does not appear to play a role in either siderophore export or uptake.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Note=localizes intracellularly, possibly to vacuole-like structures, but not found in the plasma membrane or at the nucleus.
Sequence:
MPFLDHRTGPSYGTIDQMEQHSDDEGERFLQEQCDTGRFSSDITSISEDSVQEGVRKIEAINLTWTARSLVIAYVSIFLMSFCTSLEGQTVMSLGAYATSAFSKHSLISTVLVVQNVVNAVIKPPMAKVADVFGRFEAFCVSILIYVLGYIQMAASTNVQTYASAQIFYSAGSTGLQILQQVFIADSSNLLNRAFLALLPEFPFLVTVWIGPTIADAVLKHASWRWGYGMWSIILPASFLPLALSLLLNQRKARRLNLIKPKSRPRGGVFAVLRRTWYDLDMGGLILLSAAVTLILVPLTLAANSKNGWKSDSIVAMIVVGLFCLIALPFWESSKRLAPKPLLSLHLLKQRTALAGCTLAFWYFMAFYFSVQPYFYSYLQVVQGYDVATAGRVTQTFAFTSTIAAFAVSILIKYTRRYRAFVIAGCVVYIIGMVLMMVTRHEGSTPAQILVTQVVVGIGGGLLNVPVQLGVQASASHQEVAAATAMFLTSMEMGGAVGAALSGAVWTHNIPRKLRLYLPEENKGDADAIFGKITKALSYPLGSPVRVAINQAYQETFKKLLILALIAIIPLVPLSLAMEDYKLDKMSEEPLVDPVPAEEGEIEPNRHVKRT
The following text describes a protein:
Function:
Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MESDLTVEESETIKTRSRRPLTEHRRHSLLPLQWKLAHSSRWMAQVVASEFSLLAFLLLLLMVFSKKWLYPSKSRFHQRYPQNITKRVYTSIHSMSTGLLYICISKSCLSSDNEEDNFKMWTIHPAFGVAKISFILAVGLGFVLTVWLHLPYLPCLQRMPFFGLIGIILSFCEVTLIFLTLLLFPVNLWIYELKKNISVPIGWSYFIGWLVLILYLTCGILCYLNHKNFWSLIMSSSSINATCSSSVPVSLMNTSQISKSQADILDPTQDDQKPLSSDNIALPPNPDTTD
The following text describes a protein:
Function:
N-acetyltransferase involved in oxidative stress resistance. Acetylates the toxic proline metabolism intermediate (S)-1-pyrroline-5-carboxylate (P5C), or more likely its spontaneously forming tautomer glutamate-5-semialdehyde (GSA) into N-acetyl-GSA for arginine synthesis in the mitochondria. P5C has been shown to increase the levels of reactive oxygen species (ROS) in the cell by inhibiting the function of the respiratory chain in the mitochondria. The enzyme is able to reduce intracellular ROS levels under P5C-induced oxidative stress and protects cells from damage by oxidative stress. Also acetylates and thereby detoxifies the proline analog azetidine-2-carboxylate (AZC), however it is unlikely that AZC is a natural substrate as it occurs only in plants belonging to the Lilaceae family. Does not acetylate proline.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MDAESIEWKLTANLRNGPTFFQPLADSIEPLQFKLIGSDTVATAFPVFDTKYIPDSLINYLFKLFNLEIESGKTYPQLHSLTKQGFLNYWFHSFAVVVLQTDEKFIQDNQDWNSVLLGTFYIKPNYAPRCSHNCNAGFLVNGAHRGQKVGYRLAQVYLNWAPLLGYKYSIFNLVFVTNQASWKIWDKLNFQRIGLVPHAGILNGFSEPVDAIIYGKDLTKIEPEFLSME
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC39.
Sequence:
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MNMSCSPEFMVQKPARSPEKTSFTQTCNLLSQYLKEKGSFGDLSLGMTCNVEANETPEMLRPTMNLFPVNGKSGDDCHAAPPPRKLRSMDLFPNQAAFSSPKDDALKSSMNKLGSSVEPQTAQMTIFYGGQVIVFNDFPADKAKEIMLLAGKGSSQNNSFNPNPPHINAPFTSTIATSPIESGIGVPPTPNFSTTVTQECIRSAQRPIPGDLPIARRASLHRFLEKRKDRMTTSAPYQISNSTASSSKPGNDKSWLGLAAQSP
The following text describes a protein:
Function:
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Sequence:
MEIVFVVAVAENGVIGAGNAIPWRQKSDMARFKALTIGKPVIMGRKTFESLPRPLPGRTNIVITRDPAYRAAGAVVTTSAVDAEAIARGDALRRSVTEIAVIGGAEIYRQWFGRADRLEITEVHARPDGDTHFGIDKAEWEETARIRHPAGPNDSADYSYVTYRRRPRH
The following text describes a protein:
Function:
Has lost the two conserved residues (Ser and His) proposed to be part of the active site. Therefore it could be inactive.
Sequence:
MEITAVQSSYYGDMAFKTPPPDLESLLLKERIVYLGMPLFSSDEVKQQVGIDVTQLIIAQLLYLQFDDPDKPIYFYINSTGTSWYTGDAVGFETEAFAICDTLNYIKPPVHTICIGQAMGTAAMILSSGTKGYRASLPHATIVLNQNRTGAQGQATDIQIRAKEVISNKQTMLEILSLNTGQTQEKLAKDMDRTFYLTPAQAKEYGLIDRVLESPAELPKPMAVI
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Sequence:
MTANRKELAVERAAKKEAVEQLNGVFKTTSVAVVAQYSGLTVAQMQKLRQQMKQAGASVKVSKNRLAKIALEGTDVVAIGPMLKGPTVIATSNDPVAAPKVAIEFAKANEKFVIVGGSMGKTVLNVDGVKALASLPSLDELRGKIVGLIVAPATKLAQLANAPAGKLARVIQAHASKGEAA
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MSQLSSTQSEATRRELRNRHGESIRRVRAAAEQADPIKAATEALEQTNNDFRFVSHGSEAVTDARVLSEAALLGRQEAVKLSGASFEFSSGSLKEALKSTFMIAPVTGGSSGIETSQPHNKRSKRSLAAASTSNAVSYDWDALGVLACQYLLPVPPLRVLLGPLAMDTSKKVIERQTNQRKNYKAIQPKTMNDFATEDRETTSNRVETVLDCLLDHLEEIGEDDCDLFHFAFNPKSFSQTIENIFDVSFLINEGRCGLFYDRHNLPRIRSLDPDDETKGKLPGSGSRQQVIFSVNQQEWQDIVEAFKISKSVIPNRPS
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm. Contractile vacuole.
Sequence:
MTVDNSQIPNLNQPESFADLWDGYENVSKATEKGVLLLKDITKFFKKRIQSEDEYSKTLSKLVLKFEPMAPDGYIGPRLKNTWDQIKLETLTHSNHHENICNNISTHIIEPIEGLIVDLEQKMKSIHVDAEKSFIHYQESVAKLKKAKQNYDRLCKDSFEITGVSKGETQKVQKRAIKAAQDVIKADKDYRAQINETNTSQKQFLTELIPKIMNDLQRLEMVRIHMVKSYFHRYFKSMESTPQKFNTETENLLNLINSINNEDEIQDFVRKSKTTHKYPKPFEYEPYLDRFTTPPPPPPPQISSPQLLSPRGDISIQHSSSSNSLPIFPTQHQLLSNKEKADNNITNSLSLSSDSLQTNLNNGNNGGNGNNGSNTPTKEKKPSSWGLKRFSTSVSSTSDRKLLNKQIQSIGLAHNGGNIFNCKIEDIMVAQKKKYPYLEIPFIVVFLKHKLVALDVFKTQGIFRVPGNVVDINSLKKRFDEGNYEVAPTENVYTIASLLKLWLREITEPLFPLTVYDQCIENSNKREKIFEIISSLPILNQKTISYIIELLQECGKSVNVEHNKMNFPNLAMVFSPCFLRCSHTDPNILLGNIFKEKEFVQNIIEHFKPLQVNDSLEGPPSSSSSSSTSINQSSIESPPTSPLRSSTNSNANKSSTPIKPSSPSQQQQQQQQQQQSSTPSTPLSSTTNTNVKHNILSPIVEQQSPNNGKQPIALTQTYSHLNIGSVPLIINTVNNNNQNQNQNQNQNQNQDQNQNQSKQPIQSSNQTQQQVSAPATPHTVAVNPKINQIKAETITTPQKSIGDGNGLIGQSPSAHLMSPSEVKRRSNAIYLEDQERCKQRIDELHTQVNELYSDITTIETTTYFAMQSSLLITKLTKSLESFLTIDMWNLTLQDIKEAIEKNKFVSPPPINFKIPSKMPKLSPIELVQNEQSSELLRSWLSNVTLTVNRINEYLCYLGGVVIRIHSPDTLFAISNLFTDYDLSPQQNPKFVSLTLEQSTIFIQKTLALLEPLNPFTSDELNINVKVQDTITPASFSPALISDPDCNSPPTISNTTNRLLNTSGSTDFSTTPLSSSPSTSSTSLSTNNNNNNNGNRNLDINNSPTIVITNSSLNKSALSTNNNNNNNNNNNNNPTTKLSSSTSSTSTTTTTNTNTNTTTNEKIAHAIISPSSSTTSFKFDDDEDEDEDLLEINNKLHSQLTEELKKKQQQYKQLIFDIIDMIKDKKKLMNSLDLTNSDSQLDIKSIAKLSLSLKRALDNFTSESGFDIEDEQDPIINKENDSFVNLKIMTSHFISRIVLILTTILSISNEFNSTLYQLLLPFNENNNNNNENNNINNQ
The following text describes a protein:
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MAASRCILAALVLIFVNTCSGETCEKPEVTHKLYTTTDGLIVANIAFIAEFDVKCRNGAKDLALYADVNGKVLPAVRSLDTSGYQVSWTEELSKAASGEYVIRIYDDEGYTALRKVQERCNRTCNILPPLSLLTVLMPLGTYHGAWVQSEFVAVLVAVLLWYFAYSSKMKLQA
The following text describes a protein:
Function:
May be involved in processing of pneumocyte surfactant precursors.
Subcellular Localization:
Secreted.
Sequence:
AWSLLLSLPVSLPLSLILSYRIPLRRVYPGLKTLNSLRGWGKPTVPPSLGVPSSGDNPVFVPLSNYMNVQYYGEIGLGTPPQNFSVIFDTGSSNLWVPSIRCHFFSLRCWGDSLSPFAIQYGTGRLDGILSEDKLTIGGVKSASVIFGEALWEPSLVFTLAHFDGILGLGFPILAVGGVQPPLDLLVDQGLLDKPVFSFYLNRDPEAVDGGELVLGGSDPAHYIPPLTFLPVTVPAYWQIHMERVKVGTGLILCAQGCAAILDTGTSLITGPTEEIQALNAAIGGFSLLLGEYLIQCSEIPTLPPISFLLGGVWFNLTAQDYVIQIARGGVRLCLSGFQALDIPPPTGPLWILGDVFLGAHVAVFDRGNLTGGARVGLARASPLRAGPQGASCCPELPGLGHPSPNASPGFPHPRPASTWGEYGGGGEGTGSGGGKTAQIPVLEAGDPGDGDSKISAERFFLNNELWGPRFLEGSRGTWILGRESPYFQL
The following text describes a protein:
Function:
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
Sequence:
MKYLGLCTDLYELTMAQSYLYEGKTGTAVFSLFVRKLPEKRNFLISAGLETLVERIKNFKFGDEEIKYLKSLGIFKDDFLDYLKDFEFSGNVYAIPEGRIVFQNEPLVQVEAPIPEAQLLETLVINTIQFETMIASKAVRSYLVAKGKKLVDFGFRRAHGLEAGILAARASYIAGFDGTSNVEAGREFGIPVVGTMAHSYVMIFDKEEDAFRAFAKLYPKNAIFLIDTYDTIEAAKKVVDLAKEGVPVVGVRIDSGDIVKLSKEVRKILDENGLKNVRIIVSGGVDEYKIKEWFDRGAPIDAFGVGTKFITSADAPYFDIAYKLVEYEGKPKYKLSPGKKTFPYKRQVYRYYENGKMKYDETAKWESKREGEPLVELVMKNGKLIKELPSLKEIREVVMSELEKLPENYKDITKHYEYEVKILDWE
The following text describes a protein:
Function:
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Subcellular Localization:
Mitochondrion intermembrane space. Cytoplasm.
Sequence:
MPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
The following text describes a protein:
Function:
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.
Subcellular Localization:
Secreted. Note=Secreted in plasma.
Sequence:
MWLMVFFCACFLNVSSACDFGPSSPLETGIVCRVTKPAALVLNEQTAQVIQAAFTHASYPDINGEKSIRFFGKVTYGLTNIQISNLTIGSSEVELKEDDAVYITIKNVSASFSGTLNYGYGSWFVKGGHAIDFDIFSNTDLQVNTKLTCGNNRVAADTSECYLTFHKLVLHLYGDKQPGWLKQLFTDFISFTLKLVLKSQICKEINYVANLLADFIQDKAEDFLKDGDIGVDISITSFPVIKAGYMESHHKGVLLYKKPFDISNSSLFSPSLLSENRMLYFWFSEHVLNSMAQAAFFDGRLELKLTGSELKDILKDDDTESNKTDQKIFKGVSLSNSVTQIWSLIPPEIRITPEGTLVTSSVAVQLNSTNDTESSVVGLYFETDVTATVKASYADKKLLLHLSDSIVQIKTCTSSLQTSVTEEAIKEFLHKTISLYGITAVMKRMEPALTSLMNSKGLHLFDIINPEIIPHKGYLIVQLDFGFPHHLLVDFLKRSL
The following text describes a protein:
Function:
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).
Sequence:
MVRATGSVASRSRRKRVLKQAKGFWGDRKGHFRQSRSSVMRAMAFNYMHRKDRKGDFRSLWITRLSVASRIHGLSYSRLINGLKQAGIHLNRKMLSEMAIHDPQGFAVVATQAKLALEAAVQG
The following text describes a protein:
Function:
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MDKFGSEMFLRTVDEAFENYKGRRQAIINALIKDVDEFREKCDQYNVTDGNWEIKLSSDVAEELPYSRIYKLPKQLTDKNAWLAQVAADSDTWLFSVTFYLCSIYSWMALWRERLFDKMNALPTVSELVKDNHKNLEVATENAKKRVKDKSTVSYHSSKNSKSNSEVLLHFGKVAEKAKGLVIQLSRNDAV
The following text describes a protein:
Function:
Required for the activity of the plastid-encoded RNA polymerase (PEP) and full expression of genes transcribed by PEP. Required for the proper build-up and formation of the PEP-complex. Binds single-stranded (ss) DNA and RNA, but not double-stranded (ds) DNA.
Subcellular Localization:
Plastid, chloroplast stroma. Nucleus.
Sequence:
MASCYNPWRLFPGMSTAVPAGPVTAPAHSRTCKSSKVFSALPHRRGLLFLGTRRARIKCVKDDSLHFDPSKIEPPPYSSYFDSTSGQLEPASGARASIPGKEYWPEGTAARVRAARAPAPVGESAGMPSFGTKPGSRRRGYKEQVTSASGTEGAQTDDRKDGDEPDVAIIGSGDDALEEIKDSVDEYVIYETPEEEELSEYDMDKMMGRPHPFIDPAKAMSLGEPKTSEELWWHWRRKSQEEEMWSRWQRRRPDVDTVFAKAMAETGQIKIFGDHPSRTEAALAKTRRHLYKEERLEAEQRRLEEIGPIAYYSEWVEAYKNKDTSREAIQKHFEETGEDENVQLIKMFQHQTAGEYRIMMGTDVRIQRDPLAMRMREDQIKQIWGGDPVYPTINYVQDPDEVIDYRGPEFHEPTPEVVPYLMEHGIMITKEELYARLNEEREDVNQDITYIPEAKDPMATAIDIGEHSYNEDSDDEDEDVDKAAAQPQSLEDEEDDRDDVAEVEEKVNQNWSALKSTGQAEKPKEKSKKDEMTLKEAIDDSENLTDFLMDFEETE
The following text describes a protein:
Function:
With S4 and S12 plays an important role in translational accuracy; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
Domain:
The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
Sequence:
MAKEQQVQANDLQEKLIAVNRVSKTVKGGRIMSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRSMVTIALNEGTLHHPVKGRHSGSKVYMQPAAEGTGVIAGGAMRAVLEVAGVHNVLSKAYGSTNPINIVRATIDALVDVKSPEMVAAKRGLTVEAISE
The following text describes a protein:
Function:
Dominant secreted aspartyl protease that has a clear preference for aromatic residues in the P1' position directly adjacent to the cleavage site and, in particular, Trp. In addition, it generally cleaves peptides containing Lys, Arg, Phe, Tyr, or Nle (norleucine) in the P1 position, Nle and Glu at P2, and Arg and Val at P2'. Has important roles in facilitating the interaction of the yeast with the external environment. Is able to rapidly hydrolyze Staphylococcus aureus protein A, an important S.aureus virulence factor involved in immune evasion and biofilm formation. Shows anti-biofilm properties and thus plays a role in inter-kingdom interactions, beneficial for host skin health.
Subcellular Localization:
Secreted.
Sequence:
MQLSIQAIIGFVVAAGLAVASELPSPMTVNLERRKMLVTKNDTVDFKAVRKQANALNYKYDKLLRNFRKNTGRDHPLLHLLLDLIDKRDGKGDVDLDDIGEGQLWAGDVQFGQSKFKIDFDTGSADTLVNPFVYFPHRSKSSRKTHHTFSTAYGDGTTASGFIYTDDLKIGGYKAKDVAIGLSVTKFINDEDNQGIAGMSFPAVQSFPKKFDPFFVALVKQKVVPEPVFQFTLKRGSGSTLHLGGIDNSRFQGELSYVDVNPEDGFWISEGKVNGKKIDACIDTGSSIIFGPIDEVREVITKMDGVTPFTAGGALHGAFDCSKPPKLDFEFAGQKFNLGENQVSFGKYQGQCVLSIMGQKNLPMNAWVVGDSFLQTASVVFDMGKNRMGFAPSSN
The following text describes a protein:
Function:
Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling; May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKTLILLLLLFNLTLYASATDSDEYDHCNCDDEEALFSIHTILVGQKVSDFFIAIAYFSIPIELLYFVSRSNVPFKLLFLQFIAFIVLCGMTHLLNAYSYHSHPSFQLLLSLTVAKFLTALVSCATALTLPPLIPLLLRIKVREIFLRQNVMELGQEVGIMKKQKEASWHVRMLTREIRKSLDKHTILYTTLVELSKALDLHNCAVWMPNDDRREMYLTHELKSDSVKSFHHNSIPVIDPDVLEIRKTKGVRILRPESKLGAASSGGGSTEELGAVAAIRMPMLHVSNFKGGTPELVDTCYAILVLVLPGSNSRVWTAPEMEIVEVVADQVAVALSHASVLEESHLMREKLEEQNRALQQSQKNAMMASQARKSFQTVMSHGLRRPMHSVVGMLSLFQEGNMRPEQKIIGDTMLKVGNVLSSLVNDVMDISENKKGGLQLEMKPFLLHSMLREAACIAKCLCVYQGFGFQIDVEKSLPEKVLGDEARTFQVIMHIVGYLLNTRDRGNLVFRVFVTSESGDKDDKKFGVWRSSSPVEYVDIKFDFQITGSSQSDEPISTKQQIGRRLNHNSESKEGLSFNMCRRLVQIMQGNIWILPNSQGLVQGVSLLLKFQIGPSLERYMFAPKDYSNSQFGGLKILLADDDGLNRIVTKKLLERLGCLVTAVSSGFECLGAISGSGSNSFKIIMLDIHMPEMDGFEVAARIRKFNGPNWPLIIALIANAEEQVKDRCMLAGMNGVIRKPILLHQIADELRSVLLRAGEKL
The following text describes a protein:
Function:
Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPSSNDLLGPRVGNTFLRKARVTYKRYLDASVPHCALRWCFFAFLAILYVARVVTFGGFYVITYGLCIHLLYLLLLLITPLSDPDESEGTPLPMTHTDSDEYRPFMPKVQEFVVWKQMFTVLFVCLFLTMFSFLDIPVFWPILVLYFLALFATQVGGRVRHMIKHGYVPWNAGKPKFVPKSTS
The following text describes a protein:
Function:
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
Sequence:
MNFRYQPNQQPYQPPQHNNNSNNRGIPTNYQQYPPQNYQQYPPQQYYQAPINPQQFYPGPPQQPNFVSQQTGPIPQQPPGFNNQSPIPQQQPQQPQQPQPSQPSPIPQQPLSPQSSSPSSPQHVVIQPNQPNQQQQNANRKQSALKPSVQHNTIPNIPRTHSAPPSLEEQQQQHQHQNNIKGFTPEKRTPIQHSPQYVIPPQQFGKPIYPNPQQMYFQQQPPYPYYGQPPVVPVVNQMIPQTTVKKTLEIIDPKTNEKVIITSPPKSSTNSTVLPTSNTSSSSSSPTNANGSSTPSGSGYVTSFSSGNVNLRKNKQSGETTPIKQDAASTTTSTPATPSSKAESTTEAETTSKPSTPTTVDSVSSTTTPDKSNVVTAAATTTAAATTTTTTTDTTTTTTTPEAETSTTTPATEVQSPVETTKEEQPKEEVKPTEVQPPVEPTKEEPIKEEPTNEEPTKEEPAKVEPIKEEPSVVESTTTDTKEEPIIVAEEKKQEETPVTPVTEKKEEPIVKPETPVTDSTAASTTVEKESTDSTTTATVSTTAAATTTNGKVEEELEEWEKKGEEDFNIVQSSDSSTSITPATSLVFRNSGEKIVYSKELMMSLKPKSMEEPTGPLKDLKNQIETNTNQNQLNRSGNKIGGNQQNKNMGMGGMNMNPNYPPQMNMKYPPQMNMKYPPKNYNNQVQGQQQQQQGNPNFNKYAPGYQYQQQIQQGMPPPTLQPNPYQPQQATYGITFSRDPVQPSISSQPVNEKRWVPTKVNALDDSQKVLRKANFILNKITPEKFDVLTEELLELGIVDDEKVHKGTIDLIFDKALNESKFCTMYTNLCKKIFEFEKVKKEIAKRAVFEKIGVIETENYHKMSNKQRDEFDQEHNVKAVFRTLLLSTCQKEYEKIPFETVDKVPEDLKPEEKTDFEEGQFKERKRIFGLIKFIGELFKQQMLSEKIVHGIMVSLIGELQRPSEIKLECFCKLLSIVGKTLSQNEQASKYLTSYFQRMQQLVDNSQTLSQRIRFLIQNVMDLKNSNWTLKVDESAKTLKEVEATQNKQEDNRKSNPTGVKNTSNVKNMFNASFNFGGPNVKPMMAPPMNYNKNAPGIKPPAQFQPKPYPYNNNYNNQQQQQQHFGGGNNMMNNNNNNYNRGPMGNMNNNMNNNMNNNNMNNMNSNNSTSNNSANSEIQKKWDAVSTSITDSINEFLELKDEEEFMECVKSYVPSTDLYPHVISQLISTACSKQKDEPLIKKLIFASVFDKKLFTTAQFKSGYELFISSLPDLFEDRPSAFKSVASVFYSFVLNQEGLITITQFANAFTKVLDDCGSSIPKILFEFILQFEDPKKAAQLFVDNKVGVQGFFTEKDFSKITQTAISYNKDLQPFFDIVKL
The following text describes a protein:
Function:
As a component of the tetrameric DNA polymerase delta 4 complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival.
Subcellular Localization:
Nucleus. Note=Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation.
Sequence:
MGRKRLITDSYPVVKRREGSAGHSKGELAPDLGEEPLPLSVDEEELELLRQFDLAWQYGPCTGITRLQRWHRAEQMGLKPPPEVHQVLQSHPGDPRFQCSLWHFYPL
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAGSSSGRSPAKMCRFHLPPNSFGGSRTLSSFGHSADGAYSCHQRAPLVGRHTARESEPAEEVRRRVLAPLPVLPVISMKRGSVSPARPRGAERLQSHGGGMTRRGNERSSSGPPVGPGCPRQDMGPPSRPGSIASRTLQHLFLLLLFTGPFSCFATYSRATELLYSLNEGLPAGVLIGSLAQDLHLAPREQGAKGSGPWRPPDQWDPPLSFSLASRGPGGRYVTLDNRSGELHTSAQEIDRESLCLDGAGVGGGAGDVSLSSSPSLDSCLLLLDVLVLPQEYFRFVKVKIAIRDVNDNAPQFPMPQISLWVPENAPVDTRLAIEHPAVDPDVGANGVQTYRLLDYHGVFTLDVEENENGERTPYLIIMGALDRETQDRYVTVIVAEDGGTPPLLGSATLTIGIGDVNDNCPLFADSQVNVTVFGNATVGAPVAAVRAVDRDLGSNAQIAYAYSQKVPQPSKDLFHLDEVTGIISISDEMGGSVLRLHKLTILANGPGCIPAVITVLVSIIKVVFRPPEIVPRYIANEVEGVVYLKELEPVNTPIAFFTIKDPEENSKVDCYLDGGGPFRLSPYQVYSNEYLLETTKPLDYETQQLYEIAVVAWNSEGFRVQKSIQVQVLDDNDNAPVFAQSLIELSIEENNAPDAFLTKLHATDADSGERGAVSYFLGPDAPSYFSLDKLTGVLTVSTQLDREEKEKYRYTVRAVDSGLPPRESVATVAITVLDKNDNSPRFINKDFSFFIPENFPGLGEIGVISVTDADSGRNGWVALSVMNRSDIFVIDTGNGMLRAKVSLDREQQSSYILWVEAVDGGEPALSSIAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPITEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALMQNDYGLYRLLVKVSDHGYPEPLYSTVMVNLFVNDTVSNESYIESLLRKEPEISIEEKAPQIAIEPTHKKIESTSCMPTLVALSIISLGSITLVTGMGIYICLWKGKKLHREAENLEVQIPLRGKIDVLRLDRKPMDISNI
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS29 binds GTP and is probably an active GTPase. GTP hydrolysis may be linked to subunit association. mS29 also has an extraribosomal function, being required for maintenance of mitochondrial DNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MLPKFRSRSSIIKNTERISNILSGGKLTVCGSKLGGLYTFEKCTFNKYYSSSQYQHTGRPVGGNIHSSSNQQRQKNSEAPRINEIPPSTSSVEKSTTIPNSSVVLDHLLNEGENTLEEVKPSEIHPHMSWSSKSEGKMFKIPEELLNKLNGFGALEKQKKSFSFFTSASLLHRKITTELVNVLQRSKDQGTKDGRFLLDGAPGSGRSIALIQAELFALSQPNFIVLPVHNCEGWVNSTSSYGYDEQLKLWVQPDLIKGFLTSVMKTNSDKLKKLKTFESHELLQNECIPAGTDLLSFLHKLIASSNAPKSLEIFLQELNNNTKSNSNMKVLLVIDNISILSVVTKYKDKKNNFLPPKDFYFINLLFKYISGSLTFNRGTVLAATSSQPRVSTPSLDIALGVAHRNPYKSSDETILDSLQSVHILNMEPYTLDESRRMMEYLVSSNVCLEKVDNYLQNHVLSGGNPRKFFDACTRLA
The following text describes a protein:
Function:
Activates pyocin genes, probably by binding to the sequences conserved in their 5' non-coding regions (P box).
Sequence:
MQPSIAPSTPIPRQETVELVYRIFGDVLVPLEQVRERWFRNLNKENFSKALACGRIALPVTTLDDSHKAMQFVALDHLAAYVDQRANQAGSARRAQPGADSIAS
The following text describes a protein:
Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Sequence:
MSSTDPGPSRSGLSNLASPATQHSYIDPAAPQLRSPHSANRINLVTYGQSTIKALIDPSLPVQDVIRQLCANAHLGVQEPPALFALRDDDNDELIDDANMAKKIEAGANFKLCSSPTIEAVEMVDKLSSRDDRILKMATYTLQRLIRETPFTDELIERGGVRELLNVIRDHSSGNTLAYALTSCQNLMEGFEYGWEIIDASFVAKVVSLLVTQERINVCRPATAILKKLVVSGAQDSPKTGRVVTDGRGAATTSAPAVYRYGFEFVYNEIQRERLFLQTLVNRIGSSDTTLKLYSLSLINSLLRNVSDDLFESFTSELEKLNASKAVAWLMDSSRGDELASSILEYQSNVISAAHRRMRTVVTPTDKRHVHALSYIWLQARISDEVVPNQAATQNSAFNGEQRQSIGANARYKWRRIGFASESAAKQFGRTGWLGLSCLESFVRSDPDGYAKIIQEQINRPEERRCMFAQASIEVTSILADHWNIESGSYTTSTTYLPFLLSFNKVHHLVLRFFLRMWNESGAAASDFSRVSALVRSQVDEALGKQEETSRTWFELENAFLHSEYRTVRDRQMKELEVDQDYSSKASIRNLRGRIYRESYEYVRQQRIQCLLEGAWFRNVATTAGGALGGDGKQRRESTSTIDTAVPATRSTAINGLQTQTKPWRFYRLAPNKKLLYYCDSSERFPIRGGLDDLSEKIDLSLVTEVSHHGNAGESTAKATGGDLVISLLQSPDTSLVEMQALNQSQFSEWTDGLNMLRGEGGVVSTRQTADLIETLTEIGIKVKLLDLTGEQIELPTSVQLPPLPSTTEFFFAEL
The following text describes a protein:
Function:
Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
Sequence:
MGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MRRSSASSGRSSLAPMRVKNDNGQNVRRTTGSSHRQSAVPRPWSSFGRQSFGRLSTGSSTGIPRASNIRGKGMGMGASQRRSSAYGKSRIGDSMKDPRKLSDRSLQHRMTKDIIEFLSMQGFPHQISQKLMSPPTTKLFTAIVQFLYGQFLDPSFQILKKFEEEIPRIFKDLRYPFPLSKSQMFTIGTPHTWPHILGALHWLLQLVKYSMRVDGDKLMFNEDFESNSENKILFEYSSEAYKCFLEGNDDMMSQYDQRMEDELRASGIKAEDLQTLATENMKLQEELEQLEKQEDPLIAATTLRDQLKEDAKQLQDHLEKVEHQKSGLVQNAAHLEEELQIKRQELETEQKENVRLQQIFDTQEFSPMDVELMNRQRQQLSVTLDDLNKEIERLEQQCWELEMKQSKQREQMQSVVQEYNMLARQLKLIPPTAENAHGMDYEMRLVFNAGSTANQVAMVDFVGTIKPALIQMRKQIADTCHSIEAARLTEEESLEQITDMINDKKEELGLMETRLRRIEEELDHKKEMMAREYKKHADEVQDVQNQLQEMRLTHQELEAKKDEAYKELQVSHQAAVAKVKEWEREETEYVDFLVHCVELVCAHQDKIQDHFSKLQAQAMATLQETQQIEVPTSQLLSNTDQQD