lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the piRNA pathway in germline tissues. Part of the Rhino-Deadlock-Cutoff (RDC) complex that stimulates piRNA biogenesis from chromatin regions corresponding to dual-strand, but not single-stranded, piRNA clusters. Promotes transcription of long piRNA precursors by preventing termination at canonical poly(A) sites. As part of the RDC complex, is recruited to chromatin enriched in histone modification H3K9me3 and might contribute to complex interaction by binding nascent transcript nucleic acid chains. Associates with chromatin upon exposure to homologous piRNA. Suppresses cleavage at canonical poly(A) sites by blocking recruitment of the cleavage and polyadenylation specificity factor (CPSF) complex and prevents transcriptional termination by RNA polymerase II, facilitating transcriptional read-through. As part of the RDC complex, involved in suppression of splicing. Catalytically inactive, lacking 5'-3' exonuclease and pyrophosphohydrolase activities. Stabilizes uncapped piRNA precursors in the nucleus, probably by sequestering or blocking the exonuclease activity of Rat1. May also be involved in siRNA biogenesis from dual-strand piRNA clusters.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Note=Localized to perinuclear puncta in the nurse cells of younger egg chambers. Accumulates at centromeric/pericentromeric positions in germ-cell nuclei and strongly colocalizes with the major heterochromatic domains. Localizes to nuclear foci corresponding to dual-strand, but not single-strand, piRNA clusters. All components of the Rhino-Deadlock-Cutoff (RDC) Complex associate with these nuclear foci and are required for their formation.
Sequence:
MNSNYTILNIRAHSWAEKDNLVFPTITKPVSNGWFAWSPIGQFEPNSQKVPYVVVPPSIKFPISLRYKDSPPKLEKKPNIFLDNMLQYIESSSYMYVMVRNNQQAQLNANIVCTSEVLELMMCAPYEKKTGWSLGVTRYRNTMYICRIDVEQPDPIDQDNLKRAMQEFWLRNLRTHCVFENGIKMHQHNQSSEEHLRFHGVFSFDLNGNRVLFDSPVLAEMPSTTLNGSALSWVDLQIRPMFMSRLDWPEHNRTEALKWWVKCFLLGIESLYIARRDENAHVHNIEKTLVRDLWKSCEKDWSPTVCANFMIYLLNCISQVMAPIDCPSTVYLFQFDASQGTVSYKGLRGRNQYTFVSDWFRMMLDDHTNDMCKTPNLQTMSSIV
The following text describes a protein:
Function:
Transcriptional regulator that specifies poly-innervated organs (chemosensory bristle). Also controls the number of neurons.
Subcellular Localization:
Nucleus.
Sequence:
MPHTGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSINRILRNSGLWTDEMTSSQQNAAAAAAAAAAAAHQAGSGPSNGYGGQAPPPPVTVAPPTPAATPSIARYAKPPALMMNSAGEMPIKPAPKMPPSMGHGHSHGLNPNVSGLDLSYSALHKHWLWNPSLLYYTQAHIQAQAAASGGQFLPYAGGYLPHAMAAAAASSTSALGGFTKSESSIDLSTPGAAGDALSDCDSGKSSPAALSLTASGGGNGAGSAPEASPGSTLSHSRKRNPYSIEELLKKPEKRLRLDSNRLECLESSSCESSQDSPVAPPLETPEDEDPAEAEEEQEEEDSVEVVN
The following text describes a protein:
Function:
Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain.
Subcellular Localization:
Mitochondrion membrane. Peroxisome.
Sequence:
METAASREPNTIEVLPQHKFDCRSLDAYLNQHLPGFGTEPEAKLTVAQYRSGQSNPTFHLQKGSQAYVLRKKPPGLLLPKAHKIDREFKVQKALFSIGFPVPKPLLYCSDSSVIGTEFYVMEHVQGRIFCDWTIPGVSPAERSAIYVSMIQTLAQLHSLNIQSLQLEGYGRGVGYCKRQVSTWTKQYQAAAHQDIPAMNQLSDWLMKNLPDNDNEENLIHGDFKLDNVVFHPKESRVIAVLDWELSTIGHPLSDLAHLSMFYFWPRTVSLGNQSHHLQENIGIPSMEELISIYCRCRGINSNLPNWNFFLALSFFKMAGIAQGIYHRYLLGNNASENSFQYANVVQPLAETGLRLSKRSFSTAYSQTDTTRQLFVQTRTGQEVLTRVKQFMKQHILPVEKEVIEFCVQNENSVDKWKKPLVIDKLKEMAKAEGLWNLFLPAVSGLTQVDYALIAEETGKCFFAPDIFNCQAPDTGNMEVLHLYGSEKQKQQWLEPLLQGNIASCFCMTEPDVASSDATNIECSIQRDGDSYIINGKKWWSSGAGNPKCKIAIVMGRINNNSETRHKQHSMILVPINTPGVEIIRPLTVFGYLDNFHGGHFEIHFNQVRVPATNLILGEGRGFEIAQGRLGPGRIHHCMRTIGLAERALQIMCERANQRVAFKKKLCSHEVVAHWIAESRIAIEEIRLLTLKTARSIDTLGSAAAKKEIAMIKVAAPRAVCKIIDRAIQVCGGAGISQDYPLAHMYALTRTLRIADGPDEVHLSAVAKMELRDQAQSLRAKI
The following text describes a protein:
Function:
Required for the nitrogen-regulated transport of amino acid permeases GAP1 and PUT4 from the Golgi to the cell surface.
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Sequence:
MSSTVISLAHFCDKHGPRIISVTQSAEKGTLGEELLVPDYPTESYCESCLLQFPEESTRSMRCFIEDVPFITTQYSSIRYQLLNSIIKRAFSEETMIYDNMPFIFFDDLRGLNLVIGFKLYDENARGNERRYCFILTVDSRSHDDSMKMLSEHWNFIIGGFDKMIAYIKNIHKSEFLGKNKTVENNLETLNNNAFIGSYLRANKSKFGRNLVSLTDDKFLFVRIHKWNSFLLHTVMNENKLP
The following text describes a protein:
Function:
Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKFKHSARTMADTGPGEPIASRASRLNLLFQGKPLFVTQQQMSPLSREGILDSLFALFEECRNPALMKIKHVGNFVKKYAETIAELRELQPSVKDFDVKSVVGCGHFADVKVVREKVTGDVYAMKVMSKESLLAQEHVSFFEEERSILSQSTSPWIPQLQYAFQDKKNLYLVMEYQPGGDLLSLLNRYEDQLDESMVQFYLAELVLAIHSVHQMGYVHRDIKPENVLIDRTGHIKLVDFGSAAKMTVNKMVNAKLPVGTPDYMAPEMLTGLNGDGKASYGPECDWWSLGVIAYEMIYGRSPFTEGTSAKTFNNIMNFQRYLKFPEDVKVSSEFLDLIQSLLCGQKERLGYEGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSGVLSSTRQLNPAGFSGEDLPFVGFSFIKALGTLRSESVLSSVDSPAKVSSMEKKLLLKSKELQDAQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLISARRRSDLYESELRESRMAAEEFKRKATECHNKLQKLQVKDQGKSEAGELYCKLEKINTEQQAKIQELQEKLTKAVKASSEATELLQNIRQAKERAEKELEKLQNREDSNESMKKKLLEAEERRHSLENQVKRLETVERRENRLKEDIQTKSQQIQQMAEKILELEEKHREAQISAQHLELQLKQKEQFYEEKLKVLENQMKKDLADKEALENMLRRHEEEAREKCKVLAEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKMSHQDHTDKNRLLELETRLREVGLEHEEQKLELKRQLTELQLTLQERESQITGLQAARTALENQLREAKTELEETTAEAEEEIQALTAHRDEIQRKFEALRNSCTVITDLEEQLNQLSEDNAELNNQNFFLSKQLDEASGANDEVVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRNVLGDEKSQFECRVRELQRMLDTEKQSRVRADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKVPLQYNELKVALEKEKARSAELEEALQKTRIELRSAREEAAHRKISDHPHPSTPATARQQIIMSAIVRSPEHQPTPISLLAPPSSRRKESSTPEEYSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFSEAFCRDKMNSPGLQLKEPSSSLRLEGWMKVPRNNKRGQQGWDRKYIVLEGTKVLIYDAEAREAGQRPLEEFELCLPDGDVTVHGAVGATELTNTAKTDVPYILKLESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESIVAGGRVSREKAEADAKLLGNSLLKLEGEDRLDINCTMPFSDQVVLVGAEEGLYALNVLKNSLTHIPGVGAVFQIHLIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNVFEAVKGCHLFAAGKVENGLCICAAMPNKVVVLRYNESLSKFCIRKEIETSEPCSCIHLTTYSIIIGTNKFYEIEMKQYTLEEFLDKNDHTLASAVFAASTNSFPVSIIQVNPTGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWNRLPLAFAYREPYLFVTHFNSLEVIEIQARASLGTPARAHLEIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKETNNEHHRGSSATRSSPNKRGPPTYNEHITKRVASSPGPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRLLSTRRERSPGRLFDESSRGRMPVSGARTPLAQVNKVWDQSSV
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVEKHYCRTGQRVYLHLQRTRRPKEDDSTSGTGDPPRKKPTRLAIGVEGGFDITEKYEYDEDVKIVILPDYLEIARDGLGGLPEMVRDRITSAVEALLAADSASRKQEVQAWDGEVRQVSKHAFNLKQLENPARIPPCGWKCSKCDMRENLWLNMTDGSILCGRRYFDGSGGNNHAVEHYKETGYPLAVKLGTITPDGADVYSYDEDDMVLDPNLAEHLAHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESSVQLKPLYGPSYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPSDPTQDFSTQVAKLGHGLLSGEYSKPAPESGDGEQVPEQKGIQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHFINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEERKRQAEEEKQPLPELVRAQVPFSSCLEAFGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGAGLQPGEEELPDIAPPLVTPDEPKGSLGFYGNEDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLVLPGSSGPGSTSTVADPPSEDCVATIVSMGFSRDQAMKALRATNNNLERAVDWIFSHIDDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVTS
The following text describes a protein:
Function:
Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression.
Subcellular Localization:
Cytoplasm. Membrane; Multi-pass membrane protein.
Sequence:
MKGEAGHMLHNEKSKQEGYIWGSMRRTAFILGSGLLSFVAFWNSVTWHLQRFWGASGYFWQAQWERLLTTFEGKEWILFFIGAIQVPCLFFWSFNGLLLVVDTTGKPNFISRYRIQVGKNEPVDPVKLRQSIRTVLFNQCMVSFPMVVFLYPFLKWWGDPCRRELPTFHWFLLELAIFTLIEEVLFYYSHRLLHHPTFYKKIHKKHHEWTAPIGVISLYAHPIEHVVSNMLPAIVGPLVMGSHLSSITMWFSLALIITTISHCGYHLPFLPSPEFHDYHHLKFNQCYGVLGVLDHLHGTDTMFKQTKAYEKHVLLLGFTPLSESIPDSPKRMQ
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MKTFMIILLVICSILIVGRVEANDNKRKYLLLDPCLRPNAPPGCHRQPYKPRTPVNVYSRGCTTINRCRRVQNP
The following text describes a protein:
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
Sequence:
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQDDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
The following text describes a protein:
Function:
Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MADETAPKSSKPTAEAAPKKTGYTNPALRAMGIRQLRLPSRNWMIFWTVVGTISGGIYYDRHERKKVRQQYKDAVAYLGERPLGGLEIPRKITVFVAPPPGDYLDHVLTHFRAYIKPILTAAALDFEVKQESRQGEIRYVVAEGIRNYRREQMGLPKVPSRLMVDEEEYNKAVAEQNAEVERLKAGREKHTNPNPTFQAFNSINNRPGAPSSPDSQPEEQMSISVAGTIAQEQLDKEITSKLEFNPESGVICVGRGAYKEYLAGLHEGWLGPLEDPRPDEDNRKVYEEFPNREKDDDDALGLVKTPVEEPTTAVQNVQSVSEHLNSHPEMVKDVSETISHSGDVTAVTDVEQTAAGPVDVVSETASTHDTPAASDNKTPKPLSEMSPSEWDPKAPLPEIKRKPVPKPYIRPEEYSEAELSEFYASGFENASTAHSTVSSNINQQPNDLNSPAGSGTAFVEQFFFSPIAVIPHRHIMGFMNTPLRIARYFNKRAVADEVGAATVVAVTGDTRPFDVKTDPDLLVSEEYDWPSKWVKKGQDNGSEWVQPVVVDQRVMEKVKVYQPKGEGESELK
The following text describes a protein:
Function:
Catalyzes the NAD(+)-dependent conversion of prephenate to p-hydroxyphenylpyruvate, with the elimination of carbon dioxide. Is a key regulatory enzyme in tyrosine biosynthesis. Displays no chorismate mutase (CM) activity, in contrast to TyrA from E.coli and some other bacteria, that are bifunctional and possess a CM domain.
Sequence:
MTRTVAAPPVCVLGLGLIGGSIMRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQTLTRAAATEALIVLAVPMPALPGMLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGLFNRAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLLAEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPAADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGADKWREQLAAAGRAGGVITSALPSLDSPQ
The following text describes a protein:
Function:
Positive regulator of brassinosteroid signaling.
Subcellular Localization:
Nucleus.
Sequence:
MAYHLLNPDMQINNPPFSVFNIDSSLNFNNQFPELNLNPTSLEMSNFNFQSFVGFSHENILTQTPEFPVCLTANFHGIFQEDDKNKVTIQARNDINESKKRKTIETPESSSAYSSPAVSWSGTKRKTSKGKGKKVKSDEKEEDNPRQVVHVRAKRGQATDSHSLAERVRRGKINERLKCLQDIVPGCYKSMGMAVMLDEIINYVQSLQNQVEFLSMKLSAASTYNNFNSETYILETLQRAKAYEAHIMQKLRKEGCEGVASSNQIGPLDHSFGCYPQLPYNT
The following text describes a protein:
Function:
Controls the expression of genes involved in anthocyanin biosynthesis. Regulates the expression of at least 3 structural genes: chalcone synthase, dihydroflavonol reductase and flavonol O(3) glucosyltransferase. C1 acts as a trans-acting factor.
Miscellaneous:
MISCELLANEOUS: According to PubMed:2303027, C1-I allele might be alternatively spliced, giving rise to a much smaller protein.
Subcellular Localization:
Nucleus.
Sequence:
MGRRACCAKEGVKRGAWTSKEDDALAAYVKAHGEGKWREVPQKAGLRRCGKSCRLRWLNYLRPNIRRGNISYDEEDLIIRLHRLLGNRWSLIAGRLPGRTDNEIKNYWNSTLGRRAGAGAGAGGSWVVVAPDTGSHATPAATSGACETGQNSAAHRADPDSAGTTTTSAAAVWAPKAVRCTGGLFFFHRDTTPAHAGETATPMAGGGGGGGGEAGSSDDCSSAASVSLRVGSHDEPCFSGDGDGDWMDDVRALASFLESDEDWLRCQTAGQLA
The following text describes a protein:
Function:
Converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester using S-adenosyl-L-methionine as a cofactor.
Sequence:
MPSDYAEIRNRVEHYFDRTATRAWARLTTADEKVSKVRQTVREGRDTMRAVMLSRLPDDLTGCRVMDAGCGTGLTTVELARRGADVVAVDISPQLIDIAKDRLPPELRGKVSFHVGDMADPALGQFDYVVAMDSLIYYRAPDIGRVLTELGKRTHSAIVFTVAPKTAFLMAFWWLGKLFPRSNRSPVMIPHALDKLQRHAGDSLIKIDRVARGFYISECLEYRP
The following text describes a protein:
Function:
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (By similarity). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). May act in an autocrine and paracrine manner. Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility. Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (By similarity). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (By similarity). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (By similarity). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (By similarity). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (By similarity).
Subcellular Localization:
Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Recycling endosome. Note=Localized at pericentrosomal preciliary compartment.
Domain:
The phospholipase A2-like domain represents the fully processed form after N- and C-termini are cleaved off. It is the secreted mature form found in biological fluids.
Sequence:
MGVLVVLLGVLSFLGRTLGGSPALHWDSTSCHLARPIPGRPLRSLSFLGKDAQGLALFHAHWDGHGRLQVCSRQDEPELTAAYGALCAGEITRGSFIHTPGPELQRALATLQSQWEACRGPAESPAGTREKRAAGQNGVPGIGRQWVKRGWTVPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPHNVSPFQYNYGIRNYRFHTISHCNCDARFQQCLQDQRDSVSDIMGVAFFNVLAIPCFVLEEQEACVEWYWWGGCRRYGSVPFARLQPRTFYNASWSSPATSLTPSPQNPALSRPQPMQHPQQWPSEWKESKSPSKTNATALQAPVASPGSDRASTVQLEVTHPGFQGTTGGRKPPGAHRACRSFRHLDQCEHQIGPQETKFQLFNSAHEPLFHCNCTRRLARFLRLHGPPVGASMLWELPGMTCFKLAPPLDCAEGKGCPRDPRAFKVSARHLLRLQQRRLQLQGTGTDNGQVWPSEDQGAPISFYNRCLQLT
The following text describes a protein:
Function:
Guanyl-nucleotide exchange factor that regulates small GTPases (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. Is also a regulator of the cab-1 synaptic transmission pathway. Probably by converting rab-3 to its GTP-bound active form, plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by activating rab-3 and thus regulating the trafficking of dense-core vesicles, plays a role in AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, required for fatty acid uptake by intestinal cells.
Subcellular Localization:
Cell membrane. Cytoplasm.
Sequence:
MNDKEKEICPRLIDFLVVVGKRNRTRGASQSSPDATTDTTVTYPEILRRYPTDDHKDFILPTDVTVFCQPEGCTTTSARLRKNARNDPQFFVFMLTEKDSAKVRYGICLNFYQSFDRRSTPKDEIKKVPDDAHHKKRDSHVSLTSLCFISHHPFVSIFHQVLLLLKRIIDSSNHRAAQRTGLKDVVWAILTGHYNEPIVPEVMKEIKEIETWILMLLSSPVPVPGKTKVQIEVMPMDLSQVFEFALPDHTRFTLIDFPLHIPFEILGIDMALRVLTAAMLEFKIVIQSRNYNAVSMCILSIVALLYPLEYMFPVIPLLPAYMPSAEQLLLAPTPFLIGVPSSFFHHRKIRELPSDVILVDLDTNCLQVPDDLYIPDLPEPDATHLKERLKNAINKMTTMTVDNETSVTDADFGIDIDSVDVACRVAMVQFFNSANVFGNFSEHTRTLRLYPRPVVSLQTDSFLRSRPQCTQLITDLCRTQAVEYFAECCLCPKNETFVRVQAGIESAEQVGDKPKWFSESLMPVHFMVYPNNSTLDSAIRVYNAEIDNDDYEDDSATSTENSNSIDDLVFDENQVTDAGGEVTKPLAEVNYIYKEPMTLELPQSESVVSIDSSLSSGRSSPDSSLSTSAVDSEADFARLADNLALKSNSQGAFSFDHGSDSEYESTPVSQRRKTIHNPGSDASDTPTSRGSIKSGLRMKGLTTLTDSGEKVLGPSLMNAINGYAEKSQSVFSQVINKTAPKAQALKERTMKPLANRIEQSQHIVRSKTQPNPTSQQTANQQSKNQQTVKEFCDQALVGQSVGMFSAPKLKRLMEDESLRELVCSKLNLGLEVKLSEDEYVKEVQLTKGQFKAYVKILKACLEGIEVSFNTPGCCGFASVFHVLEIAHTHYWAMGGGEVITPSSSAPSTMTTPSEHSNDILKESRPKLPASTIDLRTPTKPLGQNVTPTSTNNHEIAQSTRSPALPPPVPPREAPPIPKRNPPPLGAPPKVPEGARAPPPLPPRPKVKTTAVDETPQNLVPNNQPAQPSSPSFLADADEQTKPLLKPAPPTTLPVGKQEPCKVLPTPNEPVRHYIYQELILAVQHQIWQNLQFWENAFVDLVAQEREIVGMDQEPSEMIDRYSALNDSEKKRLELEEDRLLSTLLHNMTAYMIMCGTGQKALQQKVRRLLGKAHIGLVCSKEINKLLDELPSTQGNFIPLKPLGSRLVQKQSFTVCPGQSSDGQMMFMEVCDDAVVLRSITGAATERWWYERLVNITYSPKTKILCLWRRHDDKVHMHKFHTKKCRELYQCMKAAMERAAARGKVNVEGRALGGEFPVHDTETNQGGLLQVRCDGVAVIFAHNQIFIGLSNIKKCNTFGGNVFLLEEFDRKKGEIIQRRYFSQMADQICYAVLCVFSLAAAGHKKEEHSK
The following text describes a protein:
Function:
During the asexual blood stage, processes key proteins essential for merozoite egress and invasion of host erythrocytes. Cleaves and activates proteases SUB1 and SUB2. May process members of the EBL and Rh protein families (By similarity). Also cleaves apical membrane protein AMA1 (By similarity). During the mosquito vector stage and probably in ookinetes, cleaves CelTOS (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Note=In schizonts, localizes to exonemes which are secretory vesicles that discharge their content during egress into the parasitophorous vacuole.
Sequence:
MKRISPLNTLFYLSLFFSYTFKGLKCTRIYKIGTKALPCSECHDVFDCTGCLFEEKESSHVIPLKLNKKNPNDHKKLQKHHESLKLGDVKYYVNRGEGISGSLGTSSGNTLDDMDLINEEINKKRTNAQLDEKNFLDFTTYNKNKAQDISDHLSDIQKHVYEQDAQKGNKNFTNNENNSDNENNSDNENNSDNENNLDNENNLDNENNSDNSSIEKNFIALENKNATVEQTKENIFLVPLKHLRDSQFVGELLVGTPPQTVYPIFDTGSTNVWVVTTACEEESCKKVRRYDPNKSKTFRRSFIEKNLHIVFGSGSISGSVGTDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDYISFEGIVGLGFPGMLSAGNIPFFDNLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFYEGDIYMLPVLKESYWEVKLDELYIGKERICCDEESYVIFDTGTSYNTMPSSQMKTFLNLIHSTACTEQNYKDILKSYPIIKYVFGELIIELHPEEYMILNDDVCMPAYMQIDVPSERNHAYLLGSLSFMRNFFTVFVRGTESRPSMVGVARAKSKN
The following text describes a protein:
Function:
May act as a GTPase-activating protein for Rab family protein(s).
Sequence:
MTTDNKIQFWKRNTKVPGSIQPVYGAQHPPLDPRIHKTFLKDGPKTNALSIKSKKASSFHEFARSTSDAWDIGDDEDGTLSHVCRYVSMSCKGEIGLLENKYTTKTNRGQQKGKKKNQRAKGRKSGGTGRQGVKQEVGEDERDEKIQTGIEQCPSECKACLIHSKCSAHKEAEWLPPVGSWRNVLIRNTLHKQQSLPLRPIIPLIARISDQNASGAPPMTVREKSRLEKFRQLLASPNTDLEELRKHSWSGIPREVRPITWRLLSGYLPANMERRELVLRRKREEYFGFIQQYYDSRNDEHHRDTYRQLDADISTLGISCHVLECEVTHIHIDIPRTNPLIPLFQQASVQEVFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEFVEEDVENFDVSALPLDTQRNIEADSFWCMSKLLDGIQDNYTFAQPGIQIKVKALEELVSRIDEDVHNHFSKYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQAEAEGFSHFHLYVCAAFLIKWRKEILSMVDFQGLLMLLQNLPTIHWGNEEVGLLLAEAYRLKYMFADAPNHYRR
The following text describes a protein:
Function:
Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA in complex with the exoribonuclease xrn-2. Stabilizes and enhances the accumulation and activity of the exoribonuclease xrn-2, and thus contributes to miRNA turnover.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Domain:
XTBD domain is necessary for interaction with xrn-2.
Sequence:
MGKLEDVEAEKKLWESDDAWELRKAFMLAHYDDYPKIQLQCLSQLFINVTLLGCEYSQTLMQKIRTMGAGIAANKDRTKTGSYVKASAAKKRQAVKTSDLEGASDESKKVKMEKSPSPVARESFDERLGKLKASLAMTPHHLTGEQMMKTATNSCLMKWHVNKINQKIEITIDRYVAFRHTFSQYCVDPRDCAINTLIESILSCDAAVHEESYEIRFDGVPVDECYAKSVTRRLAKIKSAVSNGAHTVKGLTTYLDAVNMSMIQNTQKLEGWSQQLDLVTADLLLSSRVLSSTECTKPAMATIANQMSEDVCQLILNDKINVINSMKSHSSLAFQ
The following text describes a protein:
Function:
E3 ubiquitin ligase involved in different processes such as development and immune response. Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT. Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation. Also acts as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MASVEMHNFEEELTCSICYSIFEDPRVLPCSHTFCRNCLENILQASGNFYVRRALRIPLTCPNCRRTVEIPPPGIESLPINFALRAIIEKYQQEGCLDVITCPEHSRQPLNIYCLQDREPVCGHCLTIGQHQGHPIEDLHSAYMKEKEEPSKLFEQLTDINSHWEDFWLLAEKLLDQKSHVMQVVQNDKEIVLRYFKELNDILDLKKDALLSALDDVGRAIDEEFTPQIDRMTEIRVEQMELRRSTALLLEEESTVKFLKKICNVRQRVQALRQRTLPSIQSLEICPRVGPVLMEEWARTEISQIKNLVVPEIKLSLQRMQSVPAKEEKGVEEEEEEEENEEEKEEENEEEKEEEEEEDEKEEEEQEEKEEEKAEFAKIFSIFILTVISGILMLIFLFNRYTLPILHDVSSGFFSEVSQSLYHSFSNNMYIVKETVCLTYHVLKGFLWDSISCCL
The following text describes a protein:
Function:
Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.
Sequence:
MTRLPKLAVFDLDYTLWPFWVDTHVDPPFHKSSDGTVRDRRGQDIRLYPEVPEILGRLQSLGVPVAAASRTSEIEGANQLLELFDLGKYFIQREIYPGSKVTHFERLRNKTGVPFSQMIFFDDENRNIIDVGKLGVTCIHIQDGMSLQMLTQGLETFAKAQAGL