lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Participates in checkpoint pathways arrest of the cell cycle, a mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Regulates the DNA damage checkpoint pathway throughout the cell cycle, when associated with RCF5. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MDSTNLNKRPLLQYSLSSLGSQITKWSSSRPTSPVRKARSTENDFLSKQDTSSILPSINDDGGEQWYEKFKPNCLEQVAIHKRKLKDVQEALDAMFLPNAKHRILLLSGPSGCSKSTVIKELSKILVPKYRQNSNGTSFRSTPNEHKVTEFRGDCIVNDLPQMESFSEFLKGARYLVMSNLSLILIEDLPNVFHIDTRRRFQQLILQWLYSSEPLLPPLVICITECEIPENDNNYRKFGIDYTFSAETIMNKEILMHPRLKRIKFNPINSTLLKKHLKFICVQNMKMLKEKNKWNKRQEVIDYIAQETGDIRSAITTLQFWATSSGSLPISTRESTISYFHAIGKVIHGSHSTNNDNEMINNLFENSNNLLSKEDFKLGILENYNTFNKGEFSISDASSIVDCLSECDNMNGLPESNEYGLREVRKTFRNISKQGHNHGTVYFPREWKVRKLQNSFKVQAEDWLNVSLYKYNAVHSFRNITLEFGYYAPLIRKCQSYKKKYILYYLKNLPSGSSGPKQTMDKFSDIMKVENGIDVVDRIGGPIEALSVEDGLAPLMDNDSNNCDHLEDQKKERDRRLRMLIDQYERNVMMANDDLEDEETSFNDDPIVDSDSDNSNNIGNETFGRSDEDESLCEILSQRQPRKAPVISESLSDSDLEIL
The following text describes a protein:
Function:
Antibiotic peptide structurally related to lantibiotics. Active against M.luteus (MIC=0.2 ug/ml). Has cytotoxic activity against mouse P388 leukemia cells (IC(50)=1.3 ug/ml).
Subcellular Localization:
Secreted.
Sequence:
MRSEMTLTSTNSAEALAAQDFANTVLSAAAPGFHADCETPAMATPATPTVAQFVIQGSTICLVC
The following text describes a protein:
Function:
Carnitine O-acetyltransferase involved in the shutteling of acetyl-CoA in the cell.
Miscellaneous:
MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSGSTIVSSDKSGRTFKHEEELPKLPLPKLCDTLQRLKESLEPLYYADGYYQHPLDPEQIEKLSSIIRDFEENPVSEKLQSKLQSYHDTRDCYLDELHLDINNQTSTREIQDDVLPRNPFLVLADDALPNITQADRSAVLVHSAARFISALKQDLLPPDINATNGKPLSMAPFLNLFGTTRSPVFQRGEVENFDLNKPYTASDLEDPDYSSDEDDNDEPTQKDFDDRKRKHEEDIFTGNGITIKRHPDSKHILIISRGQYYTLEVLDSTNKIIYTAAELTTIFNHIIKDSSGIEKSTALGSLTSHSFRNWKYARKRLQKRYPNELHRIDSALFVLVLDESQEETTNDGDDTADISQMFNRTITERDKKCTSANCKRVFYGTSIINSKGHQVGSCVSRWYDKLQLVVTADAKATVIWDSFTCDGSVVLRFTSEIYTESVLRLARDVNAGDPQFSLWPNVTQMDPETKKLMTATISADGGGPSEIDPKLVVNKIDWSFSNILNTHVHLSETKLADLISKYDIVRASIPLGRRSAQRLGVKPDSMVQVALQIAHYALYGRMVFGLEPVSTRGFKNSRSSFINIQSQALLELCQLFISSSIDGTDKLDKFIQTCETHNNMVKHAKSGVGYEKHFNALKYLFKFHDHFGIHLSGDESSAAKDLFENPLVLPFSQPELIVANCGNAATTTFGITPAVPHGFGIGYIIKDDQVDLTVTSQFRQGDRLMFMLSWVLGEIRSYWRMSRGTSHNKTGVKISPVVDKLYEMDNAVNNPPKRNGHTVNGSRKTSSSSQVNLNRYGGFFDLEGHIDSRNISKTPSMKNLQKTFNGLTMSADNDHSSSAVSVPTEKEKLNTGHEILQIQPREVASNGLEADDETDIEIVAGNADGTSSSASSATSLNSKKRNVINSRFDIDFDRSRVGRKVATLDQ
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MESKRNTITLVNKTHLLCNVSFFLFLICTLAFCSITIASSIPCLGKIEVFSMNLGLSRGILSGPGSVPPTCHSKCCKCTPCKPTLCSVHNEGGTYYPLRWLCKCGNMFYNP
The following text describes a protein:
Function:
Metal transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
RDKTASFGLMLLRSFFLLLAFSQPASAGKGDPKHNNTVIIGMRLEGSSKPGAESSTEGIIQVFEDSVIQLRIFGHGIHESTWEIVYFAVLATTEPNFHVSNDSVCLEKSSDLVVQPYSRDVQETSAILSIAVRTLRRDVHSKNYVLCLDTGSGQPQQLVDRHNLFIQVLEDIKLELPLWLIIILMIVLLSLSGIFSGLNLGLMALDPMELRIVQKCGKPNEKIYAARIEPLRRKGNYLLCSLLLGNVLVNTSLTIISDILVGTNIVAISIATAAIVVFGEIIPQALCSRHGLAIGANTVVLTKLFMLLTFPVSYPLSKVLDWVLGKEIGTIYTREKLMEMLKLTQPYNDLLKEELNIIQGALELRTKTVEGVMTPLEECFLISSAAVLDFNTMTEIMESGYTRIPVYERDYTNIVDMLYVKDLAFVDPDDNTPLKTITKFYNHPVHFVAHNTKLDAMLEEFKKGKSHLAIVHKATNIEGEHEVIGVVTLEDIIEEIIKSEILDESDISAENPSKRRPNSARRWDFSAFRAVGNEAKISPQLLLAAHRFLSTEVQWFHPNIMTEKCLLCLLKHRDVICELKFDEENKEAPHHYLYQRNKIADYFILILQGKVEVEACKENMRFENGPFSYYGVMALGPLPPKVSQSLFLPLPKSASASRNYTSIVSVALSPYLFIDILPSTHLQYMADFTVRALTDLLYIKITRTQYQDGLLASVLETSMAVPDGQSTESASIKKKGELAPPGLSQSEER
The following text describes a protein:
Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with tbp mediates transcriptional activity (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSVDSVYKYIVFDVIRNIKSNIKNDSDTENVDESIIDEIQTMWLDRLTQTGAISNQNDPDETTATTTTTQPQSTLSTVEHENVRNTLNSLIQLNNKSQTTTTTTTSTFGNPQQYLPPQKEVSNGTSPTMNSSNGSNNNNNNNNSNNSSNSSNNNNLPSSLRSIMNPMPQNDGTLDESDNDDDNNNNNNDNDNENNKDNIDKLIIDGFKKNFNFNGDEVIPQNDGLNDDDDLDDEEIGGGGGKVEEDSLGSDLDDDDDDDPDPIIEHFVLCQYEKVSRIKNKRKCNFKDGIMHLNGKDTLFNKANGEMIWN
The following text describes a protein:
Function:
Transcription factor that prevents growth. Regulates perianth architecture in flower, mostly in the second whorl, probably by suppressing growth between initiating sepals, ensuring that they remain separate, and by modulating organ shapes. Required for the establishment of auxin flux.
Subcellular Localization:
Nucleus.
Sequence:
MDQDQHPQYGIPELRQLMKGGGRTTTTTPSTSSHFPSDFFGFNLAPVQPPPHRLHQFTTDQDMGFLPRGIHGLGGGSSTAGNNSNLNASTSGGGVGFSGFLDGGGFGSGVGGDGGGTGRWPRQETLTLLEIRSRLDHKFKEANQKGPLWDEVSRIMSEEHGYQRSGKKCREKFENLYKYYRKTKEGKAGRQDGKHYRFFRQLEALYGDSNNLVSCPNHNTQFMSSALHGFHTQNPMNVTTTTSNIHNVDSVHGFHQSLSLSNNYNSSELELMTSSSEGNDSSSRRKKRSWKAKIKEFIDTNMKRLIERQDVWLEKLTKVIEDKEEQRMMKEEEWRKIEAARIDKEHLFWAKERARMEARDVAVIEALQYLTGKPLIKPLCSSPEERTNGNNEIRNNSETQNENGSDQTMTNNVCVKGSSSCWGEQEILKLMEIRTSMDSTFQEILGGCSDEFLWEEIAAKLIQLGFDQRSALLCKEKWEWISNGMRKEKKQINKKRKDNSSSCGVYYPRNEENPIYNNRESGYNDNDPHQINEQGNVGSSTSNANANANVTTGNPSGAMAASTNCFPFFMGDGDQNLWESYGLRLSKEENQ
The following text describes a protein:
Function:
Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSKEAPMRAWLKMAGLAMSNKSWLSLGDFAGICAKTPLPMCFVVQTSSLPGGSVGATHYDRTHMNIGMVPRCYSRTVDIANTAIFQLGNAFVNILALCVILIISYNIRFKYTAIGRSEYGYFFQLCFMLICMTLVVDCGVSPPGTLAYPYLAALQIGLAGACSWALAVMGFLGFRLWEDGTRKSMLIVRGVSMVGFLLGSLVSAITFTNWIQHHPDMKTNTTALFVVMYGLNGLALLMYSVCQLVVSIFVLSNFWMTGSTILGVIFITTGQVLMYTISYEICEGVKHYLDGLFIGSICNVFALMMIYKTWDISTDEDLEFSVSISVDGDIMYNSNLKL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
QVRGVSFGMFDDATTRRLSVKGISHADGFDELNNPMIGGLYDPALGPVDNSERCTTCHLLGTHCPGHMGHIELPVHVYHPLFFQQLYQLLRAKCRLCHKFKAGDVPLQLLQHQLDLLARDALVEARNLEDALDLPRLPSDEGQDPSEGPEHLRAAFEASMARVMERQASERPNPANSIHVAKYRRELIEAFLKNTVNIKSCAHCGAASRRLTHEASVKIFANPLPQKQRARMVAQKLEEMPLLPSIAEAYLTSGHRDEPRGEDTGVSQRELWARHADLLTNIFASRVLGVNDDGSATRISSYESFFLRVLPVPPNRFRPPSLMGGQTFENSQTITLGAIIKDVDQLRDIFKMRMSEEDGNVAEYERKRVENLNRAWQQLQSHVNILIDSSLAGGRAALDVQPGIRQLLERKEGLFRMHMMGKRVNYAARTVISPDPMIGTNEVGVPDCFATRLTYPQPVTPWNVNYLRQCVLNGPDVHPGATHVMDEDGHVTVLSRELSKRVPIADQLLTPSPKARSDRPKIVMRHIKNGDWVLMNRQPSLHKSSIMAHQVRVLTGERTMRLHYSNCKSYNADFDGDEMNLHFPQSEFARAEASEIASNNFQYIGLAGDPLRGLIQDHVIAAVKMCCKDSFYDRHHYQTFVYSALKDEYKGTRIVTVPPAMIKPQRLWTGKQIITTILKNLTLNQTGMNLYGKAKIKNAWSANDKGGLEGESTVIVRNCELLCGILDKAQVGNSTYGIVHAVYEVYGGRTAGEFLSALGRVWTMWLKMHGHTLCIDDLILRPEFDAARREILDDSTTHGHEAAANYVKQDDWRDDDLLKSNLQTILRDPGESKGLDSAMSGAANKIQSKVIEKTMPHGLIKPFPHNNFQLIVQSGAKGSNVNATQISCMLGQQMLEGRRVPVMSSGKTLPSFPAFDASLRAGGLITDRFLTGLRPQEYFFHCMAGREGLVDTAVKTSRSGYLQRCLIKHLEDIKVHYDLTVRDSDGSVVQFRYGEDALDVTKTNSLTNFDFMALNYPALLSRYNVEALGDAFPGKVRQAGKMQQEAIAQPAKHDPVLATLRPDTHFGCVSENFYKKLQGYLTKDPARLADLSKGLDAKRFEQLMYLISCRAVAEPGEPVGILAAQSIGEPSTQMTLNTFHFAGRGDVNVTLGIPRLREIVMTASKAAKTPIMIVPLRLSVPQIQERARSLAARLAPVRLSDVLDRVEVHSKLAASRDGDRFRSYRIRLSLIDKEEYEEVFGIGRKELFKALENKVVARLFKMGHRSIVTSSSDKIIAQGDGDDAEAHDQEGGDDADGADVEANREIGEGDGTLAAPRQDEDQNAGDSDDDEAFANDVDMEADEGHGSDNDLEHATDQQVAELAKIAAARRKHRERVIALSPAIADYDYDSKGRWLEVELAVPASMQKMLFVTILENSAKKIMLRETKGIKSCRVHVPEPDTLQVEGLNIYELWQHAELLELNSLKCNDVNAMFETYGVEAGQRSIIRELSAVFDVYGIAVNHRHLSLVADYMAFEGDYRGMNRISMRSSTDPFLKMSFESTTDFLRASTLRGDHDTLQSNSSRLVLGAVTAGGTGVCSVVQPLVKERMTASA
The following text describes a protein:
Function:
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVRRDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAELRRRVDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSLLVPSFG
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
SLDMDYPLPLLAAESGSFAYNTMKDRVPRILTKCIDTITQKPFEVSDQNVEEGRLDCQSVIGQLSQLRSEIMTDKSLTLLDDEIDDCEVWNARFEQNRSVHQSHPTWFSSPWLYVECFMYRKIQSVLSKSNHMKKFDPFLDQKNLALLQSLPAMRNLAAFLDQVLKIDLGDAKILGLRLQDFLQVSLWGNRCDLSLSGGEESSQTTDPHKNLTTLSEFLLVDCSKKVFDYLYIINQDKKTDKVVDIILDNSGFELFTDLILAEFLLASKLATKIRFHPKRFPWFVSDVTPQDFLDTIDILGKDSSQVLGDFALRWKERLQDETFTLITDENLTSFWTLPDPFYLMKNVSPSLLQLLETSKLLIFKGDLNYRKLVSDLKWLHETSFVKALRGFTSTPLCSLRTLKAEVVVGLPTGVAESIAKCDADWMVTGKYAVIQSNI
The following text describes a protein:
Function:
Transcription regulator involved in the dorsovental asymmetry of flowers. Promotes dorsal identity.
Subcellular Localization:
Nucleus.
Sequence:
MFNKKRYLQYPQVPPSLNPRASTSVVSLNGNEILLHHHDVISGYYLASNPQNLEPDALFNGFHHDVGGTNGDPLVLANTLAKKHTPKKDRHSKINRPQGPRDRRVRLSIGIARKFFDLQEMLGFDKPSKTLDWLLTKSKEAIKELVQSKSSKSNISNSPSECDQEVLSADLPYIGSSKGKAAVGLNSNKCKGGRDAVDLAKESRAKARARARERTKEKMCIKQLNQERNKSYEWNPSVLFQSKSSQQFEVSGPSTNYEELNQESIMIKRKLKQNHPSMFGFQPENATENWDYYSNFTSQSNQLCAILDQHKFIN
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MASLRIARRAFRASMLNTSRPFSSTTFRFANANPGNAEEHDGNEEYRKKQMEKPLNPHMTNTNSTIVNEMPSVGASRPPPEFITSVDGKFTPKDSVPENTDRMTGGTQDGKGSGVNREMAVGEMEGAQFRVEPLRRDGEHEEKMRARLLYQSRKRGTLESDLLMSTFADAHLPTMTAAQMVQYDQFLDENDWDIYYWVTQEPSPTSRETAEGAGLGSEGATTNAMGTDQKKSPVAQGTDPGKQTGPELETDAWRNGAPRSGEWAQTIGTFKPAYRPVPKRWQNSEILAMLRKHVISRSAGGVHGVEMNDSTATGKGMAFMPPIFQTDQKRS
The following text describes a protein:
Function:
Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts; Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MVCTSGLKKNKEVTSENFKKNLLKMDIVALVAILVAAGIPACLASLGDRSYSFLTCLQTCENAKCRGPGLERFNTNQPRYMGLLGWDCTEECKYECMWDTVQTFQRAGKDVPQFYGKWPFVRVLGAQEPASVVFSVLNGLAHLVMIGVFRSRVPKNAPLYWTVNVYALR
The following text describes a protein:
Function:
Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASRGVVGLFLLSALPLLCLELRRGIPSLGIKDLILLSGRIFLLLALLTLVISVTTSWFNSLKPSQGHLKEGEKENEKRRRLVRERQQEAQGEKASRYIENVLKPQQEMKLKKLEERFYQMTGETWKLTAGHRLLEGDEDSEFENSSQASFETINGEAARRQNLPKFSTEISPAARPLLRKEVPDLPEEPSETAEEVVTVALRCPNGRVLRRRFFKSWNSQVLLDWMMKVGYHKSLYRLSTSFPRRALEVEGGSSLEDIGITVDTVLNVEEKEQSSQ
The following text describes a protein:
Function:
Regulator of deubiquitinating complexes, which acts as a strong activator of usp1, usp12 and usp46. Enhances the usp1-mediated deubiquitination of fancd2; usp1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing usp12. Together with rad51ap1, promotes DNA repair by stimulating rad51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for usp1-mediated deubiquitination of fancd2 and stimulation of rad51-mediated homologous recombination: both wdr48/uaf1 and rad51ap1 have coordinated role in DNA-binding during these processes. Together with atad5 and by regulating usp1 activity, has a role in pcna-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated pcna. Together with atad5, has a role in recruiting rad51 to stalled forks during replication stress.
Subcellular Localization:
Nucleus. Cytoplasm. Lysosome. Late endosome. Note=Mainly in cytoplasmic compartments.
Domain:
The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46.
Sequence:
MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWNVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQMGTVIVSGSTEKVLRVWDPRTCQKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEGFTHVYSGGRDRKIYCTDLRNPDIRLLICEEKAPVLKMELDRSADPPLALWVATTKSSVNKWPIKGILNFRSSGDYENDCSTPLSPICSQPDQVIKGGASIIQCNILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEEEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEFWPRTHINPMEEEENEVNHVANGEQENRIQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHSSSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINVDTESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQILDPNMDLRTVKHFIWKSGGDLTLHYRQKST
The following text describes a protein:
Function:
Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators.
Subcellular Localization:
Cytoplasm.
Sequence:
MNELVDTTEMYLRTIYDLEEEGVTPLRARIAERLDQSGPTVSQTVSRMERDGLLRVAGDRHLELTEKGRALAIAVMRKHRLAERLLVDVIGLPWEEVHAEACRWEHVMSEDVERRLVKVLNNPTTSPFGNPIPGLVELGVGPEPGADDANLVRLTELPAGSPVAVVVRQLTEHVQGDIDLITRLKDAGVVPNARVTVETTPGGGVTIVIPGHENVTLPHEMAHAVKVEKV
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MYHLCYYSVLGRVRGVGVVSGHTFGSLPGIVRYLEEGEESSPGDQAQALLERLRRQARERQLKKQQEAAATPEPSRKPQAPDPETEPPRHPRTPPGQADAQVEPKGKIKKRKREEESPSKDAAPENVEVVGEETHSLLGGSGNRPEKEGAPEKTEEKQTTETSPGPADALILGGFGKKALQKVQPFLPQWLAEPSRVRKSVTEDLVPIRDIPGIHPDVQKKLEANGISSYFPVQAAVIPVVLESATHGFLVGRGGYRPRDICVSAPTGSGKTLSFVIPVVQVLSERAVCHIRALVVLPTKELAQQVWSKVFHTYTEQTALRVALITGQKPLAKEQELLVQETDTGYRSLADIVVATPGRLVDHIDQTPGFSLRQLRFLVIDEADRMIDSMQQSWLPRVMAAVFGGTGSGGPGELLQRTAPGVITAASSCRPQMPLQKLLFSATLTRNPEKLQQLGLYQPRLFSATGTREGPAGDGKYTFPAGLSHYYVPCSLSSKPMLVLHLLHQEDFPRVLCFTNSRENSHRLFLLIQAFGGVKVAEFSSRFGPGQRKLILKQFEQGKIQLLISTDLVINYDAPHYIRSYVHRVGRTARAGRTGLAYTFLLKVQEQKFLRMAPSTRPHLCLRRESRLQPGRGEPRPPSPGLGAVPERWEGPEP
The following text describes a protein:
Function:
Architectural component of nuclear structure that plays different roles in controlling nuclear size and morphology (Probable). Involved in the modification of chromatin accessibility by interacting with SWI3C, a component of the chromatin-remodeling complex, to thus reduce the suppression effect of the complex. Acts as positive regulator of drought resistance and modulates root growth. Positively regulates the expression of genes related to root growth and drought resistance.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing NMCP1 exhibit enhanced tolerance to drought stress.
Subcellular Localization:
Nucleus matrix. Nucleus lamina. Note=Localizes predominantly at the nuclear periphery.
Sequence:
MASPRSAGGVGGGGGGGGGSGGAAAGDDAIWSKLREAGFDEESLKRRDKAALIAYISRLESEIYQYQHNLGLVLMERKELTSKHEQLRAASESAEIMHKRERAAQQSALAEARKKEENLKKSLGIQKECVANLEKALHDMRGETAETKVSYESKLAEALQLMEAAHKKFDEAEEKLLLAKSLEAESIRTHNAALRSLHDIDDREDQLRRDRISCELENEAKEKEISLQRKSLNDMKKILHEKEEVLLKEQALLNQRDENILERLAYVTHSEKRVEEEKNILEAERKVLLEEKYKLELKMEAIVSREEALIQKESLLDKRESELLILQETIASKERAEIERLNQEQAIALERRKHDFESEMANKQMSFDAAMEVTRNALHQRECALSEQESVVVQRSQNLDLQLAELASKEKALAGRSDELKEEEEKLLLHREAIHNELQKEREEIQRIKSDLEKEKAFFEEEKREAIQAQQDLAITQADRDELLTLQMKLKEEIDSLRAQKRELMADADRLQAEKERFEIEWELIDEKKEELQKEAIRIAEERRAITEYLKNESDIIKQEKDNLRVQFKSNSETLSREHKEFMSKMQQEHASWLSKIQQERQDLKRDIDIQRVELLNSAKARQMEIDSYLREREEEFEQKKAKELEHINSQKEMINTKLEHVAVELQKLKDERKEATLERERREQELSEIKGTIEALNNQREKLQEQRKLLHSDREAITVQIQQLNVLEELKIDSENKQLSLLQHDKSKLGSDINVKDNHHDNSHSSPKQRFGRKLDLSPVSTPISWVRKCAQVIFKRSPEKSASHDQFVQNGVPKKVGDSVDVEDVNLDFAKVGQKRLNHLVSCDQTEVLEPKRKHRRSTIQKVNGGEITSNCLSALEEKCSKNEHDEAPLGLSNTCKEHEYGDKGPENLTKPGEPASSVDVPYVNGIVDNSDSVQEEPSVEATVSATETSNVDGPEDNNDSDEEDEEEEEEKTSSAKKLWRFLIT
The following text describes a protein:
Function:
Probable dehydrogenase required for replication of Brome mosaic virus. Involved in vacuolar processing and morphology.
Miscellaneous:
MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MLDPRILPYYDPAVERKIAVVTGGNTGIGWYTVLHLYLHGFVVYICGRNSHKISKAIQEILAEAKKRCHEDDDGSSPGAGPGPSIQRLGSLHYIHLDLTDLKCVERAALKILKLEDHIDVLVNNAGIMAVPLEMTKDGFEVQLQTNYISHFIFTMRLLPLLRHCRGRIISLSSIGHHLEFMYWKLSKTWDYKPNMLFTWFRYAMSKTALIQCTKMLAIKYPDVLCLSVHPGLVMNTNLFSYWTRLPIVGIFFWLLFQVVGFFFGVSNEQGSLASLKCALDPNLSVEKDNGKYFTTGGKESKSSYVSNNVDEAASTWIWTVHQLRDRGFDI
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Sequence:
MQNLASQIQEKAVDSQQQLRTIMVQIAAKERALKISELAKKELEDVGEDKAVYTSLGKMFMKSDLASVRTHLDAEMASLREDIEALQKKQTYHETTASNAEQHLQKIKESIS
The following text describes a protein:
Function:
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MFDKIKNFSEILSNMGSFREKMEEVKKRIASIRVVGDAGAGMVTVTASGEGQITNVFINKQLFDADDNKMLEDLVMAATNDALKKAKEATAYEFQSASGGLDFSEISKMFGGKFG
The following text describes a protein:
Function:
Mitochondrial GTPase involved in assembly of the large ribosomal subunit (By similarity). Plays a role in expression of the mitochondrial translational machinery (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MTTWFPGHMKTTLKRLRDSVSKNDVIVEVRDARIPLSSRNPALETLAANRKRVVVYNKCDLAFPSAGDLCKTRALNSVRAFEETYVETLARWETIQTLRRYVGTVSNVPECIKRLLQLLQKLTYSDHAASNRTVKVFVVGMPNVGKSSVMNALRHASLHRRKVAVVGSHPGVTRNVGEVVRLFEGKNVYMVDTPGIMLPTILQPEDAIKFALVHAMKDGRLHNAVVVDYLLYRLNLIDPNTYTRLSSPTNDVSTFLHNAAVHTGKLGKGGTVNDDLIASYVLQLYRTGFFGAFVLDSMEEEQWQQRLALEKNLVRRNQRRVCSTRKKA
The following text describes a protein:
Function:
Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA. Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVQLRPRLSRIPAPAEAMVDEDQAASEEEEAEHGLLLAQPSSGAAAEPLDEEEDADDEAPEELTFASAQAEAREEELRVRASARRDKTLLKEKRKRREELFIEQKKRKLLPDAVLEQLTTASEADIKKSPENVKVNLKKKSEQHAKGRNSKKVKVQKVQSVGQIESYMAVRLKDEDLRDSRQEAAKHFIHSCLYGSDSKRTTVNKFLSLNNKRSPVKKAAAQFLTSTWGAQKQQNAKRFKKRWMAKKMKKKTYK
The following text describes a protein:
Function:
Involved in DNA replication and cell separation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDKADTSAAPVGASSPIPIPIDQPQRSNSQQGSIGNGSGSHRTPGHIPTHRQSFAENLRNPPPSPRAQRHLSLSQSAIQELLLKNPSSKQPNPLFANRDWRDVAVGELVTQDDVKWADLDTSVEEATMLLLRSSPANVVHVREKSTDNTPVSTFDYNDLNAYILVVVGLAHPEDDEQVALYDEIARKARERVAIPLRDIQPICRKEVLVTFSADEPLSRGVEVLGSGIHRVFVTTGNGDVIGVLSQLKVLGFFWEEGVSFPEIDRLYPVPLRDLKLGTHQIIAINADRPLAEALTLMSNEGLTSVAVVDNGMNVVGNISTADVRLLTSAASMPLLESTCMHFISVILTERGVERGQDSFPVFYVNPYSTLAHTVAKLTATQSHRMWVVESPSPSPSVPGTPLLQPVSSASSGQVAGATPTTPATTSTASGTPALSTATSTGSTIVIPSAVPTASLPPPVSSSVPAAALPGAHLSGRLTGVISLTDILNMFARSSGLHPSDPGEQRARRRRSSSASMRPSMEASRPSAEFIRRLG
The following text describes a protein:
Function:
May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.
Subcellular Localization:
Mitochondrion intermembrane space. Note=Enriched at the cristae junctions.
Sequence:
MPRGSRSAASRPASRPAAPSAHPPAHPPPSAAAPAPAPSGQPGLMAQMATTAAGVAVGSAVGHVMGSALTGAFSGGSSEPSQPAVQQAPTPAAPQPLQMGPCAYEIRQFLDCSTTQSDLSLCEGFSEALKQCKYYHGLSSLP
The following text describes a protein:
Function:
Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore.
Subcellular Localization:
Secreted. Target cell membrane; Multi-pass membrane protein.
Sequence:
MKALAALCVTICLLYQANGKSITDPVQGSRREVRQINDPPPVDCKMSAWSQWSPCDPCTNTTYRSRSIEVFGQFKGTVCSNPIGDRRLCVPKTKCQMDDPPVCKSSQWQCTFTRMCINKNLRCNGDNDCGPTDESDEEDCDVIRSPCGKTAVFESDIALKAGYGINILGSGPRNNPFDNKVYNGQCNRIRDPNSMEYNRLPWNVGVLHYETKVEESSSKEMYEDIHSLIKEITRETSSTFEIGLNFKFTPTETSKNDEGGNAGSAGEGGNAGSAGEGGNAGSAGEGGEVASPNEGGAAAGPVEGGGGEGPATSGGAGVGGDPGVSGGIPDAAPGFGISGSAGANYKQTTTNIIKQLSELTTTKRKTFMRVKGRVELATYRMRQRGLEVSSTFLDDVDALPLQYEKGQYFSFLEEYGTHFTKNGKSGGEYQLVYVMNEDIRKQKHVTEATVKKCFELGLKADFQLTPAAEGGGEVKPLNDCNSLTNTDTDEKNNKGVIDKVLIEVKGGSAASAVAMKSQLTKDGILDYNQYVEWAKTITILPALIQSEPEPIYNAIPLSFPDAQPRRDNLKRALDEYVAEYSVCKCQPCQNGGTVIQIDGQCKCMCLPGSEGVACQIIDMEMMKGKTFEQLGNWGCWSAWSHCSGGRRTRSRSCNNRGLTNGICKGDKTSEDYC