lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MVKAVAVLGNSNDVSGTISFTQEGNGPTTVTGNLSGLKPGLHGFHIHALGDTTNGCLSTGPHFNPNGKEHGAPEDETRHAGDLGNVTVGDDGTASFTITDNQIPLTGPNSIIGRAVVVHADPDDLGKGGHELSKTTGNAGGRVACGIIGLQG
The following text describes a protein:
Function:
Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Sequence:
MPSVAEVIIRVLEDNGIQRIYGIPGDSIDPLVDAIRKSKVKYVQVRHEEGAALAASVEAKITGKPSACMGTSGPGSIHLLNGLYDAKMDHAPVIALTGQVESDMIGHDYFQEVNLTKLFDDVAVYNQILINPENAEYIIRRAIREAISKRGVAHINLPVDILRKSSEYKGSKNTEVGKVKYSIDFSRAKELIKESEKPVLLIGGGTRGLGKEINRFAEKIGAPIIYTLNGKGILPDLDPKVMGGIGLLGTKPSIEAMDKADLLIMLGASFPYVNFLNKSAKVIQVDIDNSNIGKRLDVNLSYPIPVAEFLNIDIEEKSDKYYEELKGKKEDWLDSISKQENSLDKPMKPQRVAYIVSQKCKKDAVIVTDTGNVTMWTARHFRASGEQTFIFSAWLGSMGIGVPGSVGASFAVENKRQVISFVGDGGFTMTMMEMITAKKYDLPVKIIVYNNSKLGMIKFEQEVMGYPEWGVDLYNPDFTKIAESIGFKGFRLEEPKEAEEIIEDFLNTKGQALLDAIVDPNERPMPPKLTFKQAGEYVLSIFREKLEGI
The following text describes a protein:
Function:
Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection. Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b. Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior. Required in chordonotal organ neurons for behavioral synchronization to low-amplitude temperature cycles and mediates circadian clock resetting by temperature. Together with Ir40a and Ir93a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Perikaryon. Cell projection, cilium. Note=Low levels detected in the axon segment adjacent to the perikaryon in some sensory neurons of the antenna but not detected along axons as they enter the brain or at synapses within antennal lobe glomeruli. In coeloconic neurons, prominently expressed both in the perikaryon and in the distal tip of the dendrite which corresponds to the ciliated outer dendritic segment innervating the sensory hair. Relatively low levels detected in inner dendrites. Detected in dendritic bulbs of the dorsal organ cool cells.
Sequence:
MILMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNAADHPGKLVDGVILGHSGEKFEKSKAALRPRFNQYPATFKPRF
The following text describes a protein:
Function:
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTLYGETFPSRLLLGTAAYPTPEILKQSIQTAQPAMITVSLRRAGSGGEAHGQGFWSLLQETGVPVLPNTAGCQSVQEAVTTAQMAREVFETDWIKLELIGDDDTLQPDVFQLVEAAEILIKDGFKVLPYCTEDLIACRRLLDAGCQALMPWAAPIGTGLGAVHAYALNVLRERLPDTPLIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSGDPVNMARAFALAVESGRLAFEAGPVEARDKAQASTPTVGQPFWHSAEY
The following text describes a protein:
Function:
Required for the import of both fatty acids and cholesterol during growth in macrophages and in axenic culture. Facilitates the uptake of these lipids by stabilizing protein subunits of the Mce1 and Mce4 multi-subunit transporters, which transport fatty acids and cholesterol, respectively. Required for full virulence in vivo.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGRKVAVLWHASFSIGAGVLYFYFVLPRWPELMGDTGHSLGTGLRIATGALVGLAALPVVFTLLRTRKPELGTPQLALSMRIWSIMAHVLAGALIVGTAISEVWLSLDAAGQWLFGIYGAAAAIAVLGFFGFYLSFVAELPPPPPKPLKPKKPKQRRLRRKKTAKGDEAEPEAAEEAENTELAAQEDEEAVEAPPESIESPGGEPESATREAPAAETATAEEPRGGLRNRRPTGKTSHRRRRTRSGVQVAKVDE
The following text describes a protein:
Function:
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity).
Subcellular Localization:
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane (By similarity).
Sequence:
MSQSGEENLQGSWVELHFSNGNGSSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRAEIDSHSFGEKNSTLSEEDYIERRREVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF
The following text describes a protein:
Function:
Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. + phosphate.
Sequence:
MTGSLNRHSLLNGVKKMRIILCDTNEVVTNLWQESIPHAYIQNDKYLCIHHGHLQSLMDSMRKGDAIHHGHSYAIVSPGNSYGYLGGGFDKALYNYFGGKPFETWFRNQLGGRYHTVGSATVVDLQRCLEEKTIECRDGIRYIIHVPTVVAPSAPIFNPQNPLKTGFEPVFNAMWNALMHSPKDIDGLIIPGLCTGYAGVPPIISCKSMAFALRLYMAGDHISKELKNVLIMYYLQYPFEPFFPESCKIECQKLGIDIEMLKSFNVEKDAIELLIPRRILTLDL
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPSQIKIKTSALGRLIKEEKLYKQETAEQAARVEKMKANGEDEYDIKKQIEVLKDTEQMVPVMRKKIDEMKASLEGILVSMRRILGGRLGGKVTPPLVLGMKLMKR
The following text describes a protein:
Function:
Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity. Binds to the calcineurin-dependent response element. Plays a role in azole tolerance.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes in the nucleus in a calcium- and calcineurin-dependent manner.
Sequence:
MSNNPHPQDDGSQLYDNFEISPPSIVIRKADTDQSLNKIMLNQESQDINNYYTENVKNDNNPNNSYQDYTFSGNSSNQQHQQQQQQHLYEDLPTQFHYSNNSFFEPPPAPTVELTDDPLPNFNYPPSNIYINDNASDISLNTKDLPQFTTNEFLSPTSQLSTPFSPGHYSQSSQDFLQVNHTNGSGNNNNNNNNNNLLNPRSPSQYSSHSLYSDNSSQPASPFLDAASHVSNNSFIPPVIPTALSDVGSQNLDPSHNLGLSANQHFDSVNEFLSTGEIQLGQSVSSTNLPSMEEDSIKWGGGNGQEAYTSLAMMEQRASADNSGMRLATHQFSETQIKQEDQQTNMNHQYTFSNPQMNFDFDITVTPPPQQLEVKPFGNDKDMNNSSGTTNNNNNNSQFDIVSTAATNNSNQLLTENNLSNYNQLQRTEQGNDNDSLQIHRDATGIIISINQAPEEIAAKTPSLFSNSSANSSIHNSPRSDIDNKSGQYYNNGGDGNSLVPNSQLLPSSPNSNNDNYGGGGSSNDENNLLNPEEFQSVKRGRRKSHASRTSTNPNSLSPRSRSRSRSSAKSSNDAVISDNDESDDVLQSREKMLELALPSSSSKRTQKHPSLYACHLCDKRFTRPYNLKSHIRTHTQEKPFICSKCGKSFARSHDKKRHELLHQGIKNFKCEGYLQDGTRWGCGKSFARADALRRHFQTEAGKQCVKRLLLEEQANSSGKPLATSSGVEIT
The following text describes a protein:
Function:
Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLSCNICGETVTSEPDMKAHLIVHMESEIICPFCKLSGVNYDEMCFHIETAHFEQNTLERNFERINTVQYGTSDNKKDNTLQCGMEVNSSILSGCASNHPKNSAQNLTKDSTLKHEGFYSENLTESRKFLKSREKQSSLTEIKGSVYETTYSPPECPFCGKIEEHSEDMETHVKTKHANLLDIPLEDCDQPLYDCPMCGLICTNYHILQEHVDLHLEENSFQQGMDRVQCSGDLQLAHQLQQEEDRKRRSEESRQEIEEFQKLQRQYGLDNSGGYKQQQLRNMEIEVNRGRMPPSEFHRRKADMMESLALGFDDGKTKTSGIIEALHRYYQNAATDVRRVWLSSVVDHFHSSLGDKGWGCGYRNFQMLLSSLLQNDAYNDCLKGMLIPCIPKIQSMIEDAWKEGFDPQGASQLNNRLQGTKAWIGACEVYILLTSLRVKCHIVDFHKSTGPLGTHPRLFEWILNYYSSEGEGSPKVVCTSKPPIYLQHQGHSRTVIGIEEKKNRTLCLLILDPGCPSREMQKLLKQDIEASSLKQLRKSMGNLKHKQYQILAVEGALSLEEKLARRQASQVFTAEKIP
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNFILYIAVIIIYLTNIHCKNVYNIKKLSGKNNYKYNKISNNVKRLSNMNPPYYKRKDYLNIRMNKKTIQNFHTTNQNIHYKKFKNFVNKSKNKNKLYYLYIPNNDTNSIKGKKNKQNNKVLEIYFQQKKLLAQYFNNLKSSFIYKLKNTKIITKLFLSSSLLILTLNVIGLKPEDIALHSKRVLRAFEFYRIYTSALFYGDISLYVLTNIYMLYVQSNQLENILGSSEMLSYYISQISILSIICSYIKKPFYSTALLKSLLFVNCMLNPYQKANLIFGININNMYLPYLSILIDIIHAQNLKASISGLLGVTSGSIYYLLNIYLYDNYNKKVFKIPKFLETYLDSYDTIEIIQ
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MLLAILAALLGAEVRQCVYYENDSFTLVPLEDKGHNCVATTISDIEVFNETGWMRFNVTTSASYPDFIQMRAVGFAEGKIFQHHIFNHYHNLKDWFLFAYLHADDYPQELYDFLQENLDWTRSTAYKYAEVDSFWRQVAYTLDHFDGLVEAYRATAPQEEMLSELDLWTYLSSGDLLDIVNFAVPSTRMDFSKMTREEISDYLAFRSHCSGLVYYNGDTVYIGQTAWFFYGGMTRVFKGYTLNLNDVSNAAETLTFSSYPGFSYSFDDWTVTSQGLVIIETTANVLNTSLYDNCTPRSVLTWIRSQVASRMAVSGAGWHQANSQYNSGTYNNQWIVVDLKQIESMTVYKNNFVWVSEQMPGYIVSEDVAHDMTYGGYYFPSYNTPFFDELWIVAGYPSVAEGDASYRYDKNPRGLMFARDVPQITGIDDMKRIMRYNKWQTDPLAITEGQTEPDPGNGISARYDLRLDESRRKAFGGYDAKILSYNGHSRKMIAYFISGPTTDDQEPWDFSKSTLYCPRRGLKDGPYQYDWQELHLPVYWHNNM
The following text describes a protein:
Function:
Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
Sequence:
MIQIFICWNGDCTHVAAPSIADETLQFANLIYGSSFRYLLQRGRMHAFRCLSARVLKQHRGARTSLLDEVATLHKATAVRTFHKSPLQNRSSAAEAVRLEPFEDEAAPSSECLPTTTSGWEKAGRGPRAGASRLRGRGSEEEGPPIEDWRTAAGYHASTSGRGFQRGVADGQGEVADGQRERRLREMARAAPRFVWQGGGSAEPARVTAPHAGGGSSQSGDGPQFPPLPEQVFGRPSSAQGQRQGMLGWKDSPAPEPFNRENISVRQQALESKLETHRSGESPLANPSPLRGFETESLVDGFSGFRITPPPPLDDPDVSPTLVDNFGRRHTYLRISLTERCNLRCKYCMPAEGVELSPSDSLLSTDEILQLATVFVANGVDKIRLTGGEPTIRRDFVEICRGLKQLDGLRTLAITTNGLILQRQLPALRDAGVDLLNISLDTLVPAKFELLTRRKGHHKVLQSIERALELGYDPVKVNCVVMRGVNDDEVGDFVELTREQPVNVRFIEFMPFDGNVWDSKKMVPYAELMAAVKTKYPTIARLQDHPTDTAKNFRVEGFRGTVSFITSMTDHFCAGCNRLRLMADGNLKVCLFGPAEVSLRDALRAGATTGGLEDIIGSAVRRKKARHAGMFEIQRTQNRPMIHIGG
The following text describes a protein:
Function:
A DNA-guided RNA endonuclease. Uses short ssDNA sequences as guides (gDNA) to bind complementary target strands, resulting in cleavage of the target RNA. The cleavage site is 10 nucleotides downstream of the residue base paired with the 5'-end of the gDNA. Binds ssDNA better than ssRNA, binds dsDNA and DNA-RNA hybrids but does not bind dsRNA. A 2 nucleotide 3'-overhang (possibly on the guide strand) may help load nucleic acids into the complex (Probable).
Miscellaneous:
MISCELLANEOUS: In the structure with dsRNA, the nucleic acid is not found in the expected channel, only the two 3'-terminal residues interact in a possibly physiological manner with the protein.
Domain:
Has 4 domains; N-terminal, PAZ, Mid and PIWI. The N-terminal and PAZ domain are joined by linker 1, the PAZ and Mid domain are joined by linker 2. The domains assemble in 2 lobes; the PAZ lobe consists of the N-terminal, L1, PAZ and L2 domains, while the PIWI lobe has the Mid and PIWI domains. The PIWI box is exposed on the surface of the protein. The PIWI domain assumes an RNase H fold and has the catalytic residues. The N-terminal and PAZ domains are relatively mobile and move further apart when in complex with RNA.
Sequence:
MGKEALLNLYRIEYRPKDTTFTVFKPTHEIQKEKLNKVRWRVFLQTGLPTFRREDEFWCAGKVEKDTLYLTLSNGEIVELKRVGEEEFRGFQNERECQELFRDFLTKTKVKDKFISDFYKKFRDKITVQGKNRKIALIPEVNEKVLKSEEGYFLLHLDLKFRIQPFETLQTLLERNDFNPKRIRVKPIGIDFVGRVQDVFKAKEKGEEFFRLCMERSTHKSSKKAWEELLKNRELREKAFLVVLEKGYTYPATILKPVLTYENLEDEERNEVADIVRMEPGKRLNLIRYILRRYVKALRDYGWYISPEEERAKGKLNFKDTVLDAKGKNTKVITNLRKFLELCRPFVKKDVLSVEIISVSVYKKLEWRKEEFLKELINFLKNKGIKLKIKGKSLILAQTREEAKEKLIPVINKIKDVDLVIVFLEEYPKVDPYKSFLLYDFVKRELLKKMIPSQVILNRTLKNENLKFVLLNVAEQVLAKTGNIPYKLKEIEGKVDAFVGIDISRITRDGKTVNAVAFTKIFNSKGELVRYYLTSYPAFGEKLTEKAIGDVFSLLEKLGFKKGSKIVVHRDGRLYRDEVAAFKKYGELYGYSLELLEIIKRNNPRFFSNEKFIKGYFYKLSEDSVILATYNQVYEGTHQPIKVRKVYGELPVEVLCSQILSLTLMNYSSFQPIKLPATVHYSDKITKLMLRGIEPIKKEGDIMYWL
The following text describes a protein:
Function:
Involved in the production of 12-oxo-phytodienoic acid (OPDA), a precursor of jasmonic acid.
Miscellaneous:
MISCELLANEOUS: The four allene oxide cyclase proteins (AOC1, AOC2, AOC3 and AOC4) are encoded by duplicated genes. They are very similar, and most experiments involving antibodies do not discriminate between the different members.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MIMASSAAASISMITLRNLSRNHQSHQSTFLGFSRSFHNQRISSNSPGLSTRARSTTSSTGGFFRTICSSSSNDYSRPTKIQELNVYEFNEGDRNSPAVLKLGKKPDQLCLGDLVPFTNKLYTGDLTKRIGITAGLCVLIQHVPEKKGDRFEASYSFYFGDYGHISVQGPYLTYEDTFLAITGGSGVFEGAYGQVKLRQLVYPTKLFYTFYLKGVAADLPVELTGKHVEPSKEVKPAAEAQATQPGATIANFTN
The following text describes a protein:
Function:
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. May play a role in the regulation of the circadian clock (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome.
Sequence:
MLFRSVVNKPRFGCGHNGAPFTSPLQSLLQCYQCVKQDEHISYGDLGRAVPPFGCAFSTVPGMSHVLAVANEEGIVRLYDTECGDMQRLVVKEFMAHTNAVFDIAWVPGEHKLVTASGDQTAKLWDVKAGELIGECKGHQCSLKSVAFSKFERAVFSTGGRDGNIMVWDTRCNKKDGFYRQVNQITGAHNAIDKQTPSKVKKRKPSIRGLAPSVDSQQSVTVVIFQDEYTVISAGAVDGVVKIWDLRKNYSTYRQDPVPVKLFPYPGNSTRKLGYSSLVLDPTGTNLFASCTDDNVYMFNATGLKTDPVSVFRGHQNSTFYIKASVSPDGQFLLSGSSDHSAYIWQVSDPLAAPINLIGHCQEVTSVAWCQSDFTKIATCSDDNTVRIWRLNRSSEDSSESNKTDYVGWACKKKFEPSSMAAILCTPGKPSMIPSSSLMSSPTPATCAPSNTGDLPLPSSTPLSALLPTSKLQTPKRINNGGLGASPKQMSSSKISIKDWVTRTPKSSKGTDSKTPSPRKAFTPVEQYPIVSNARVQLPYEKRAKRRLETSSEDVEHVCLDNCCVMELEPRLKKSKLDLCSLNERDCRDDKCLRLSDLSKEFDQELSPSPSTSLHMNATDNPPTLSPLSEMKSDFVDKENSSPEKNWLSALGHKFKSDNSSPQFKSSSSPSSRNSTSKKHQPRNAPNSPVSVPTTPGSMRKICTYFFKKSE
The following text describes a protein:
Function:
Inhibits the host uracil-DNA glycosylase (UDG), an enzyme which removes uracil residues from DNA by the base excision repair. Interacts with host uracil-DNA glycosylase and prevents the latter from binding to DNA. Since the viral DNA polymerase efficiently incorporates dUMP into DNA, the virus needs to prevent the deleterious effect caused by host UDG when it eliminates uracil residues present in the viral genome.
Sequence:
MVQNDFVDSYDVTMLLQDDDGKQYYEYHKGLSLSDFEVLYGNTADEIIKLRLDKVL
The following text describes a protein:
Function:
Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it is a coregulator for the expression of ribosomal genes, while its own expression is induced by the cell cycle specific activator SBF (SWI4-SWI6).
Miscellaneous:
MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities; MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALPLIKPKESEESHLALLSKIHVSKNWKLPPRLPHRAAQRRKRVHRLHEDYETEENDEELQKKKRQNRDAQRAYRERKNNKLQVLEETIESLSKVVKNYETKLNRLQNELQAKESENHALKQKLETLTLKQASVPAQDPILQNLIENFKPMKAIPIKYNTAIKRHQHSTELPSSVKCGFCNDNTTCVCKELETDHRKSDDGVATEQKDMSMPHAECNNKDNPNGLCSNCTNIDKSCIDIRSIIH
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSSDIDNSIKNIKISNSGALGNDDEQSEIANYYAGKTIFITGASGFIGKQVLEKLLRSCGGVKAIYVLMRSTKRHTSSERLQLMLNSKLFHRMTELDGELVNKVFVLEGDISKPHLGLRDADIQKIISQVNVVFHLAATVSFTEPMRVAVSLNIVGLRSMLELCKQIQHLQALVHVSTAYANCTRSHIEETIYPPPVFPKKILHVAEWMSDDVFQLITPMVLEKHPNTYTFTKSIAETLLIQERGTLPVAIYRPSIVTASFQEPFPGWVDNLNGATGVLTAVGSGFLKSVYGIGSLSADLVPVDLVANSIIAVGWKLASQKNPSSEVPVYNFTSGTRKPITWNEVGIHLTDIFRRFPMDNPTSIPKAFVTNNRLTHAYFLRIEIFLRLMALDFIRRLCGHKPRLLRIHGNVIRLMNVMEYFTSNEWTWSTDNVDKLYGSMNRRDRQLFNFDLRRVHWPTYLESYCIGIRQYTLHQDLKNLPTARKTLKWLLIARRLMLITSFLALFRIFVGRFEVISSMWRFFTSFIYGVFNKMPWFIKAR
The following text describes a protein:
Function:
May bind amino acids.
Subcellular Localization:
Nucleus.
Sequence:
MMEIAYQPRIDSEIESLVERINPPRVCVDNDSDPECTLIKVDSANKYGILLDMVQVLADLDLVISKCYISSDGEWFMDVFHVTDQLGNKLTDRSLILYIQQAICSSRTGGITKEMQSNLKREVQQRHVSTEHTAFEITGINRPGLLSEISAVLSDIGCHVTAAVAWTHHERAAMVIYLEDGFNGGPIIDPIRKAQVKDHLDTVMEAHHIVGDVSHVVVRVVEAKGVPVGWAHTERRLHELMYGEGDYENCFDCDCFGDRCDALWRGRCERIHVTIEACNGYSMVNVKCRDRPKLLFDTVCALKELQFVVFHAVAGAKGSTAEQEYFIRKKNGGTLETEGQRERLRHCLVAAISRRASQGLKLEIRTENKMGLLSDVTRVVRENGLSITRAEMCTQGEIAVGSFYVTDVNGGETGPSEVEAVVRELGGAVVSAVKGVGMMPRRIGSTSDSVEQDKAKSSIGRMFWSKLERLSTSIRSL
The following text describes a protein:
Function:
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.
Sequence:
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVGIGIKKAVVRDVKKHKGYPFEISNDLESLIEDEEIDIVVELMGGVEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQTAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGYSIKLLGIAKKHPDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSLMLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISAILAQNDISLNNVLQKEILHSNKAKILFSTHTTNEKSMLNALKELENLQSVLDTPKMIRLEN
The following text describes a protein:
Function:
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
PRAKVSMSDKGTVSPKEKEAAEKRGRGRPRKQPQEPSGSPTPKRPRGRPKGSKNKTAPALQRGLLGLRSISPAVSEPQTRWPANWSAPYAVPVGHPDNSQ
The following text describes a protein:
Function:
Component of the anaerobic respiratory chain that transforms nitrate to dinitrogen (denitrification). NorB is the catalytic subunit of the enzyme complex. Shows proton pump activity across the membrane in denitrifying bacterial cells. The mononitrogen reduction is probably coupled to electron transport phosphorylation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSFNPHLKFQSQAVAKPYFVFALILFVGQVLFGLIMGLQYVVGDFLFPLLPFNVARMVHTNLLIVWLLFGFMGAAYYLIPEESDCELHSPKLAIILFWVFAAAGVLTILGYLFVPYAALAEMTRNDLLPTMGREFLEQPTITKIGIVVVALGFLYNIGMTMLKGRKTVVSTVMMTGLIGLAVFFLFAFYNPENLSRDKFYWWFVVHLWVEGVWELIMGAMLAFVLIKVTGVDREVIEKWLYVIIAMALITGIIGTGHHFFWIGAPTVWLWVGSIFSALEPLPFFAMVLFALNMVNRRRREHPNKAASLWAIGTTVTAFLGAGVWGFMHTLAPVNYYTHGSQLTAAHGHLAFYGAYAMIVMTMISYAMPRLRGLGEAPDARAQRIEVWGFWLMTISMIAITLFLTAAGVVQIWLQRIPADGAAMSFMNTADQLAIFFWLRFIAGVFFLIGLVCYLYSFRQRGRVPVVVAAPAAA
The following text describes a protein:
Function:
Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell junction, gap junction. Note=Colocalizes with beta-tubulin, acetylated alpha-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center (By similarity).
Sequence:
MKKANRSAGSVPKVSGISKPQTVEKSKPENSSSAPTGVKPVRPGAAAALSKTKSNDDLLAGMAGGVNVTNGIKAKKSTCSSAAPSAPAPAMTISENKSKISTGTSSSAKRSTSAGNKESSSTRERLRERTRLNQSKKLPSVSQGANDVALAKRSRSRTAAEGDIRMSKSKSDNQISDKAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGISEDHCEGEDRSEVKETIIAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPGNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGVPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFGRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDTIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSELEEKDTERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNAAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRSNYGELPVQEHLLRTSSTSRPASLPRVPAMESAKTISVSRRSSEEMKRDISASEGASPASLMAMGTTSPQLSLSSSPTASVTPSTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQNIDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKKRNFTLAFQAAESVGIKSTLDINEMARTERPDWQNVMLYVTAIYKYFET
The following text describes a protein:
Function:
Antitoxin component of a non-functional type II toxin-antitoxin (TA system). Does not neutralize the effect of any of the RelE or ParE toxins.
Sequence:
MFWIFVMAKPASLSIELDSDLDRRLSEIAEGMDQPKTAIIERALRDFVELRDWQDAAIDEGLRAAEEGRVFDHDKVGEWIDSWGTPNERPMPSRD