lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLEKLVDSLWKICRKSKFQHMTPIADAVDTFCFEPLHTPSSPPFVRDAVDVKRWMMLVVIALMPTIFAAVWNSGLQALVYQSSDPRIMEAFLHISGFKSYFSFVSQEIGIGSVLFAGCKIFLPLLFISYAVGGTCEVLFAIIRKHKIAEGLLVTGMLYPLILPPTIPYWMAALGIAFGVVMGKELFGGTGMNILNPALTGRAFLFFTFPAKMSGDVWVGSNPSRIKESLATMSSLAEKSHFDGFSQSTCLQVLNSTPPSVKRVHIDAIASNILNLEHVPTQDVLQTQFATWAESYPGLTVDQLSLEQLQNFVTTPITEGGLGLLPAHFDSACSLTEAVYGIGKFSTGNLFFGNILGSLGETSTVACLLGAGLLLLTGIASWRTMLSFGLSAFFFAWFFKIMSILTTGNAGAWAPAKFFIPAYRHLCIGGLAFGLVFMATDPVSSPAMKLAKWLYGAFIGFLTILIRLINPAYPEGVMLAILLGNVFAPLFDNIALKQYRQRRI
The following text describes a protein:
Function:
Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls. Catalyzes the NADH-dependent reduction of the double bond of 2-trans-enoyl-[acyl-carrier protein], an essential step in the fatty acid elongation cycle of the FAS-II pathway. Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates. The mycobacterial FAS-II system utilizes the products of the FAS-I system as primers to extend fatty acyl chain lengths up to C56, forming the meromycolate chain that serves as the precursor for final mycolic acids; Is the primary target of the first-line antitubercular drug isoniazid (INH) and of the second-line drug ethionamide (ETH). Overexpressed inhA confers INH and ETH resistance to M.tuberculosis. The mechanism of isoniazid action against InhA is covalent attachment of the activated form of the drug to the nicotinamide ring of NAD and binding of the INH-NAD adduct to the active site of InhA. Similarly, the ETH-NAD adduct binds InhA.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target; MISCELLANEOUS: Many isoniazid- and ethionamide-resistant clinical isolates contain mutations within the inhA locus. Resistance to isoniazid and ethionamide can be conferred by the single substitution of alanine for serine 94; this drug resistance seems to be directly related to a perturbation in the hydrogen-bonding network that decreases the binding of NADH and the INH-NAD adduct.
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Sequence:
MPRKRLTGIVVSDKMDKTVVVAVEKLVQHPLYKKYVKRTKKYHAHDERNECKIGDVVEIEETRPLSKTKRWRVVRIIQRFEPERVVKEKEDIQEEIEAVEGKGGVES
The following text describes a protein:
Function:
Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants.
Domain:
Kinase-interacting sequence (KIS) is specific for the alpha catalytic subunit interaction and Association with SNF1 Complex (ASC) is specific for the gamma non-catalytic regulatory subunit interaction.
Sequence:
MNSQNPDDHEDTTVVGFEVPVSPVSSYNNVYSSTEDETRDPPAVPPHLQHSLLGNQGSMELAYAPQNVVLNHLYIENRDAPRSVVALGFSHRFRTKFVTVVIYKPVQRRGSANV
The following text describes a protein:
Function:
Small monomeric GTPase which cycles between active GTP-bound and inactive GDP-bound states (Probable). In its active state, binds to a variety of effector proteins to regulate cellular responses such as intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (Probable). Involved in multiple pathways of endocytic transport (Probable). As a critical component of the endocytic trafficking machinery, involved in establishment of morphogen concentration gradients during pattern formation and organogenesis, for example of the TGF-beta homolog dpp/decapentaplegic. Involved in the development and function of the nervous system. Maintains the integrity of endosomes during embryonic development. May be involved in vesicle fusion and budding during synaptic vesicle recycling. Maintains synaptic vesicle size uniformity (important for allowing quantitative release of neurotransmitters), probably by preventing homotypic vesicle fusion. Involved in endosomal trafficking during Ca(2+)-triggered exocytosis at the presynaptic terminal. During oogenesis involved in clathrin-mediated endocytic uptake of yolk proteins and their storage. Required for maturation of early endosomal precursors into mature yolk granules. Associates with endosomal membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P(2)) and mediates its removal. PtdIns[4,5]P(2) removal contributes to endosomal maturation by affecting the ability of PtdIns[4,5]P(2)-binding components of the early endocytic machinery, including factors involved in clathrin recruitment and actin polymerisation, to remain associated. Functions upstream of Rab7 in endolysosomal vesicle maturation but not in autolysosomal vesicle maturation. Involved in trafficking and turnover of lysosomal proteins. Stimulates the Rab7 guanyl-nucleotide exchange activity of the Mon1-Ccz1 complex, possibly by recruiting the Mon1-Ccz1 complex to vesicle membranes and enhancing its subsequent recruitment of Rab7.
Subcellular Localization:
Perikaryon. Early endosome. Endosome, multivesicular body. Presynapse. Presynaptic endosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytosol. Cytoplasm. Cytoplasm, cell cortex. Note=The GDP-bound form localizes mainly to the cytosol and does not associate with vesicles. During early oogenesis localizes homogenously to the cytoplasm of germline cells. From stage 8, corresponding to yolk-protein uptake, accumulates at the cell cortex in a phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P(2)) dependent process, particularly in the oocyte.
Sequence:
MATTPRSGGASGTGTAQRPNGTSQNKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALAGNKADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKNDGANNQGTSIRPTGTETNRPTNNCCK
The following text describes a protein:
Function:
Beta subunit of a guanine nucleotide-binding protein (G proteins). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth.
Miscellaneous:
MISCELLANEOUS: Present with 1640 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MPQASTFGSHSLEAHPLHIQPAVHIKLSKEERSHYREQYDSLKYISNYVSVFDQALSDNIDSRIRKENEALLKKYYESRKPFTFTSFRQGSVISSSDSSTGFTERTKTYCFLNDFVSNCVNEVDPYTLKMTVRNRNTALNMENLDDERKSKDDIYDFEDNTDDECNAKCHGAFHYSSERLEILRSRSTISYFKYYKKLLTVDLRDSDVLKRHNLWMPMITRRFRFLLVSSSKPEDVRLTTPIPTFSESDLDIFKNKTCPLFINGTDCVPRSYDTFSGSSVIASIFSEYKLPSLSYHCSVELNDQLFIVGGLMACHRYDEEAPDLKDFYVDGIKNLPPPLIPELINNPSMIPNPHLYCFSLTSSRLTRPDISGYIPPPLVCTQGCKLTERHIFLYGGFEIKSETQVDDKGRYFIRKRAFLNNTGYILDTVTFNFSKIELVAPPYQFAIYNNFSPRFGHMQASISNSNNNVSNENTTTSAKGRRSISPYRQGNGDHKIDDLVGSPGSTDYLEDDAIPPVTNPRSTDSLSSKHCSTATHICSSVNTILIFGGYSQTGDDKYEAMNDMWKINIPVVSRGKRNYYKFADTVTATKIPIIDDPELWPSRRAFSACCVPDYFTKDVEPIETRLLRNLKNDFSIDLEIRPGNKPSQPLFPNIPHSRKEKKSGRDSMHISNSNNSTSEDTSSKSTRNTTSSPPTSPKHTPPLNPSKKCASIGRTIAFHGGSDGYDVCSDMWWFDFDSETWTKIDLYAKTQEESDGLVPINLCMVGHSMTTVGHKVVLIGGLRQGDVDRIYRDETLPEEVISGVPLGSGVINVVDLNTQCLQGCKLIRNDGDTKESVIMDPHVGTPHQVLAVAGTIELVKGTMTLIGGVVAGREDISSLYLRGAVLQFILPSMNLAN
The following text describes a protein:
Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Localizes to apical dendrite of pyramidal neurons.
Sequence:
MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILSSRRLRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHGVDSNAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHVATLAEHQDRQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWKKYLQGLGPEGKEEGPRSSVTETEADVKTT
The following text describes a protein:
Function:
Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSDTEKPIKSEEPVDEGVDRVDEEENVEEPAEDVGEAAEEASEAPEEAPAEAATTTEAAPADDDEDDSDLSDLDEDEIKNAAIEDDDDDYNKLSAHRRKVQSSGKKTLKKRATKDSRAADDDEDEIDHSHIDLDPSMARRREIEARIDAAMKPASQRRKKLGEDDIEMMQDERISNLREKMRNAAIADAESNREGQPATHKLQLLPEVKDVLQKHHLADSILDNNLLEAVRIWLEPLPDASLPSYSIQEELFDALVRLPIKSIHLRESGLGKVVTFYRKSKQPQLRIKRIADKLVADWTRPIMGRSDNYREKVVSTRSFDPSTQEIALAVAAKRAQTLKDGTLAEKQAERRRRAHIPSAQPANYRVAPKSEIIPQNRGGSTNDMTFKRLKGKLGVTKTGKKKSGVSIEGRGLNG
The following text describes a protein:
Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm, P-body.
Sequence:
MNPVSKKLKPNNTRADGPAREEDEEDSEHERKSVEESITTQLKNRMLASGEWLRLQKILMVKLKGSEWEEQLRCAAETRALEPDNPTLTKLIHHLRPIAQNTIPSEIKHEISTSIEQFIRANIEEEDDDDDADHQQLQNNNDDDDDEEEEDEEAMEEVV
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
SENKGLWSQERKKATGVFAAMDLSYEWTCPICLETFKNPVTIDCGHNFCQACLSQYWGSANRSSSCPQCRQMVPQRSFQPNRLLVSMIERWKKTGTCAKHWLPLNRFCKEDETLLCSVCERSKEHLDHVAVSWEDVAPEYKEQIEASMKSLQKRRMLVLKQMSIEAHGKKECLKQIELENQKISSAFDQMQNFLKEKKCFWLGQLQDLESNVKEKHEKNISTLSKEVLYLGNLIAVMNEKFQQPGDEFLQRSHCVCLSFQFAVLPSMQHGLQNKWRTKVTIYLETTFGMLRNFSPHNGRKITAQLSMDVTLDPNTANAFLILSGDLKSVICGTEEQKVPNVPERFDWELCVLGCDRFTSGNSWWEVEVKKEGEMWVLGVAKETIRRKRSFIPNPSEDTWAIGKPSGKSFSSNELWAFTSPKPTLLILRHSPRKILVSLNYEEGRVEFFDADSDELIFTFLAASFRGETIRPFFWVTPGVWLKC
The following text describes a protein:
Function:
Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MSMYPGWTGDDSYWAGAGTTASSQSASSGTSASASSSAAAAAAANNLKTYELYNHTYMNNMKHMLAAGWMDNSSNPFAYNPLQATSANFGETRTSMPAISQPVFPWMKMGGAKGGESKRTRQTYSRSQTLELEKEFHYHKYLTRKRRQEISETLHLTERQVKIWFQNRRMKHKKEAKGEGGSNESDEESNQDEQNEQHSS
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSVLEQLGALDIGTNEQVDETLQRIADEEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQLAESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLLRRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGIEKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEVNQPIIEAFYGQASSSLIDMVSILQHECDTEVKNLLMEFNKNRQIQYRSKQVNESTQRSAGGGNLGSNSIQALGHYRKPSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVETCVPEKEQFDIMERYEKIMKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYESGQQCSSMVDDVFFILRKSIRRALTTQSINGTCAVINNVAACLDGDFVNALKAPLKSGYPSGYIDLAQAYNAIQTSLQQGKLHSSDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQTTQVERQMLDSCLTELKAVRDALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDGLLNSFKNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGATSWSVRDKMTRISQIATLLNLDKITELSEYWNPENNKEMSSWHLTPNEVRTFLTLRNDFRIEDIKRLQL
The following text describes a protein:
Function:
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). The first step in the biosynthesis of lovastatin is the production of dihydromonacolin L acid (DML) by the lovastatin nonaketide synthase lovB and the trans-acting enoyl reductase lovC (called the lovB-lovC megasynthase complex) via condensation of one acetyl-CoA unit and 8 malonyl-CoA units. The formation of the LovB/C complex is essential for the integrity of the catalytic chamber to the complete total synthesis of DML acid. Dihydromonacolin L acid is released from lovB by the thioesterase lovG. Next, dihydromonacolin L acid is oxidized by the dihydromonacolin L monooxygenase lovA twice to form monacolin J acid. The 2-methylbutyrate moiety of lovastatin is synthesized by the lovastatin diketide synthase lovF via condensation of one acetyl-CoA unit and one malonyl-CoA unit. Finally, the covalent attachment of this moiety to monacolin J acid is catalyzed by the transesterase lovD to yield lovastatin. LovD has broad substrate specificity and can also convert monacolin J to simvastatin using alpha-dimethylbutanoyl-S-methyl-3-mercaptopropionate (DMB-S-MMP) as the thioester acyl donor, and can also catalyze the reverse reaction and function as hydrolase in vitro. LovD has much higher activity with LovF-bound 2-methylbutanoate than with free diketide substrates.
Sequence:
MGDQPFIPPPQQTALTVNDHDEVTVWNAAPCPMLPRDQVYVRVEAVAINPSDTKMRGQFATPWAFLGTDYAGTVVAVGSDVTHIQVGDRVYGAQNEMCPRTPDQGAFSQYTVTRGRVWAKIPKGLSFEQAAALPAGISTAGLAMKLLGLPLPSPSADQPPTHSKPVYVLVYGGSTATATVTMQMLRLSGYIPIATCSPHNFDLAKSRGAEEVFDYRAPNLAQTIRTYTKNNLRYALDCITNVESTTFCFAAIGRAGGHYVSLNPFPEHAATRKMVTTDWTLGPTIFGEGSTWPAPYGRPGSEEERQFGEDLWRIAGQLVEDGRLVHHPLRVVQGGFDHIKQGMELVRKGELSGEKLVVRLEGP
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MIIRPVDEVRGELNAPPSKSYTHRAYFLALLAEGESTIENPLVCDDTLATIEAIRSFGAGVDGKTVVPPEEPSPGFVYARESGTTARFSTALAGGIGGKTLIDGARRLRERPMDGLVKALKGLGAEVDGFSLPLTVKGPVKSGRVSVDASKSSQFVSGLLLLGAEVGLKVEARNPVSKPYIEMTLRTMEAFGVEFEREGFSFEVYPGVKGTRYKVPGDYSTASFFLAAGALYGKVRVNNLLREDVQADMAFLDALEEFGARVKRGRDYVKVEGGELKAVALDCSDFPDSFPILAVVAAYAEGRSVIRARQLRFKESDRVRAMAVNLSRMGVKVRELEDGLEIEGGRPRGAKVETFNDHRIAMAMSIAALGATGPSIIEDTESVSKSHPGFFDDLRRLLE
The following text describes a protein:
Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Subcellular Localization:
Secreted, extracellular space, surface film.
Sequence:
MPQAGYPGCRGAMAESHLLQWLLLLLPTLCGPGTAAWTTSSLACAQGPEFWCQSLEQALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIFQDTMRKFLEQECNILPLKLLMPQCNQVLDDYFPLVIDYFQNQIDSNGICMHLGLCKSRQPEPEQEPGMSDPLPKPLRDPLPDPLLDKLVLPVLPGALQARPGPHTQDLSEQQFPIPLPYCWLCRALIKRIQAMIPKGALAVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLRCSMDDSAGPRSPTGEWLPRDSECRLCMSVTTQAGNSSEQAIPQAMLQACVGSWLDREKCKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHNPDL
The following text describes a protein:
Function:
Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MSDDGAREDACREYQSSLEDLTFNSKPHINMLTILAEENIQFTKDIVAIIEAQIAKAPPVEKLPVLYLVDSIVKNVGGAYLEVFAKNLVNSFICVFEKVDEGTRKSLFKLRSTWDEIFPLKKLYALDVRVNSVDPAWPIKPLPPNVNASIHVNPKFLKPTEETPPKPTPPPPTPSLTQEQLIRQQLLAKQKQLLELQQKKIELELEQTKAQLAASPSLALNHHASAPVRFNASPKVNPTVPVPQTKSWPPAPSEKLSTRDPRLNRSGTTAVNPKEQVTHKKESPAAPSFQNAPEKRGQASSERPAKLDKLRIPKKDNSAVEEKSKSKSMLPSGKVMPVRPRGLESEQSKSAEVNKKDPRLHKQMHERMDSKDEDVREKKRSSEKKDRDEGSKNLDHQKLSSNRGKLINGSVNKHEKLETFLKQEIKVNKANVRKRSRSRSPPVHSPKRKERRSSPKRKTRSISPPPKSGKSRLSKHPHDDAFPQPSARDERTKKSVPDSRRPKRPLEDRPAEKKDGSLQRISAAEHKDLKDGKRWRSGWEENKHPKHSDTDLSHGRMGIQKHKTWNTNQRPPTPRTPKQHRLSVDSNIQIPEALHSASKRDLLRKASKRRADGEISNDEFLSVAHQINQLFQYQEERQRSDSWDESCDEGVYPSRKKQETISDAYLEHKLKLRRTQLHRPVQRGGHLPLHEMYHYPPHHEVSEQYSESLDVHKMSGDPIKPLSDHEDHRRIDRPPSCTGSTFRNSPSPVGLDGICGKSTVLPFERPSSPSEMDQQPEGDISPRFESPNSVHSGTGPDDGPISVEGLPRHDHFLEQGRSGRIHGESPGNTPSHSEGPTTQVNAARHDGPIHQRFDRYKNPQAPFDGPSSHMREPRLDGPPRPFVPPSRYESNTGGFDGSGGPVRFSGHRFDTPHHFEQFPKAPERPVRFNNPQVSHRPMRFVEPHNVRFDSPTPVHYDHSMPQNRFVNPPRFDNPQMQQGPPGYEEPHFPARIINYDEQQGPVRFDNPTCGIRFENPVQPEPLRFDAPPVMPRYDPQGPPRYCGPNIPNQLRPQEPTMYDQTQGQGPMINPTVPPPNFNMPPINSFGGPAQQFSMQQNVSQTSNFSVPVPTSSDFQGSFRPPFPGPGVGGVPQPMMGAQNFMPQNPMPFQPVSQFPQPEPEPLRQIDVNDLMSKLISTGIIKPAPTDSTADSPSASQTISVPEEEEEEEEQEQEEDDSVPDLTGFILDDMKQRHESIITKLYTGIQCYSCGMRFTASQTDVYADHLDWHYRQNRSEKDISKKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVQKTQEAAKEREFQSVKAAADVVHELCEICQEQFEMYWEEEEEEWHLKNAIRVDEKTYHPSCYEDYKNTSSFMDTTPSPNKMLTENPLTAFLKQEQDDETSCSSIKEEPADDDMEAPMVKEEVQVKLEGESQTSAIVF
The following text describes a protein:
Function:
Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide.
Sequence:
MAYTRSKIVDLVDGKIDPDTLHQMLSTPKDPERFVTYVEILQERMPWDDKIILPLGPKLFIVQQKVSKKWTVRCECGHDFCDWKDNWKLSARVHVRDTPQKMEEIYPRLMAPTPSWQVIREYFCPECGTLHDVEAPTPWYPVIHDFSPDIEGFYQEWLGLPVPERADA
The following text describes a protein:
Function:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons.
Miscellaneous:
MISCELLANEOUS: Probable human APOBEC3G ortholog; MISCELLANEOUS: [Isoform 4]: Lacks exon V. Found in cell line MDTF.
Subcellular Localization:
Cytoplasm.
Domain:
The CMP/dCMP deaminase domain 1 confers deoxycytidine deaminase activity, whereas the CMP/dCMP deaminase domain 2 mediates RNA-dependent oligomerization and virion incorporation.
Sequence:
MQPQRLGPRAGMGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKNKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILRPCYISVPSSSSSTLSNICLTKGLPETRFWVEGRRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELSQVTITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPKRPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHHSFLSRLYTGTGAFEVVGRRRLWFGVSGAIVAVAIASIVFRGFTFGIDFKGGTTVSFPRGSTQVAQVEDVYYRALGSEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAFGPKGTDGQPSKQAISDSAVSETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAMLFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTSLIGVLPVLALMVVAVWLLGVGTLKDLALVQLIGIIIGTYSSIFFATPLLVTLRERTELVRNHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVGITQASSQSAPRAAQGSSKPAPGARPVRPVGTRRPTGKRNAGRR
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH).
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MEKTKSSLHGHANGGLTTVLSIDGGGIRGIIPGVMLAFLESLLQKIDGDHVRLVDYLDWVVGMSTGGLMASMLTTPNKNNRPLYAAKDIVPFYRQHCLKIFPQPRYVYSSHVGKIIYYLKCLVGPKYNKKYLRKLLKETLGDKHLQDMLTNIAIPTTDMLADRKRSFGSTGGSSYESKYMELEMNDDTLSGTLASVDIATEESLNDLVKVGEALLKKPVSRLNFGIGKLEPVYPEVTNEEALVRYKFALLFSLLSCVNSINYHTDYFCFVP
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MADESAVALRCIECSNVVPSLYQEYSPGNIKLTRCDRCHCYADEYVEHEMMVVWIDLVLHRERAYRHLLFNVPLQHRQNLKGYLWKSTIAILLLDSGKRWLHDHKATTIFDGPIWPTLSSFFRCFLTELVLGTLPYTAVILLLVHHWKLAPKRRWLDVLLAVHVSSFFKLFAIPMLIWRFERAMVVLLDFFVLTSNVTALKVLLETSYPCAGTLVICASLLHLPFNGVSWYASKS
The following text describes a protein:
Function:
Required for the formation or budding of transport vesicles from the ER.
Miscellaneous:
MISCELLANEOUS: In the process of transport, may migrate to the Golgi apparatus and function in subsequent transport events.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein. Note=Endoplasmic reticulum and the early Golgi.
Sequence:
MANQSTETNQPSNMQTYGVPIYAADWIPEVDVRSKIIMDPEKSEDDDESSSSSSSSRSCIVLSGGGGEGRSGISNVILICRVDLNTNSLSEQPLGRLVVGSDLPYRMAVHPREGGLICALPNSCKLFHWEDIMSREDNQAGESEEVIKELRDVGQQLALAFNPEGSVLAAGAEDGTLRVFKWPSMNTLLNESQAHSSVKCLTFSESGQFLVSLGGPVCRVWDVNASAAVASLSKEKDEMFASCRFSVDSAGNEVLYIAANTERGGSIITCDTKLWKRKWSKPIKKNSISAFNVSADGKLLAIGTLEGDVLILESTRMQTIQVVKKAHLGLVTALTFSPDSRGLVSVSFDSRARLTMIEQKGDKPGVRWWLLVLLIVLLYVVAYYYMKAKGIIP