lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress.
Subcellular Localization:
Nucleus.
Sequence:
MDRSREAEMELRRGPSPPRAGRSHEVDGDKAACHSCCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEVGEAQLGELRVSEGLDGCASPTKSTSACNRVLNGAVPTDGSKILLRSSRKEAEGAASAQEDAEAMVQCSFCKSRFERKKDLELHVHQAHKPFKCRLCSYVTLREESLLSHIERDHITAQVPNGSEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFKEPWFLKNHMKAHGPKAGSKNRPKSDLDPIATINNVVQEEVIVTGLSLYEICTKCGNLFTDLDSLNAHNTVHRKVEASRNPAPAEEGDTEDPPDTKQFFLQCLNLTPCVAGDVSPSGQAGRRVAELDPVNSYQAWQLATRGKVAEPAEYLKYGTWDEALAGDVAFDKDKREYILVSQEKRKRESDAPSTQAPPRKRASVPGDPMLSGHLDPRPASRPNRRAAATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRDRDPEGDRAVRARCGSLSEGDSASQPSSPGSACATADSPGLAEEVVDDSGEEAVSEPASGGQPGHCCSSGEVAPILLSNGDPSHKLGNNLPEEDISEPTVGIATPSVSILENSSRETTKGPEQHRHSLDLKMPAFHPRQEASTPERVDFPSSMEIASLQHTLDSQAGHSKEKLSDLHKEHCGVGKRASAPDLVPLDLSMKSSREDPSSKEASSLQTALVIHPCPYCNHKTYYPEVLWMHKRIWHRISCGSIAPPWTQPSGHKSICSNLAFLARSGRTGPPPALGGKDCQPLLLARFTRTQVPGGVPGSKGSSSPLGVTTKAASIPKNKESPSGGPCAPWAPGPDGYRQTRAGHGQDPPSAAVQGPLPKPKQEASSRLAPSPGSGGLSRSATPTPSVITRVGAQPSANSKPVEKLGVPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPSKGEGGSPLPPREAPVKPAQELRTLATCAAGPRGDAALQAPPGAPPTLHSIQQEPAAAEGQEKRLDILSIFKYIPKDFATLYQGWGVSSPGPEHRGTPRTQARQGDFVCVECGKSFHQPSQLRAHLRAHTGERPHCPRDCAGRAPPKGDLETHLQHPARDSVDCGLTGDWKAPSSDHGHFGEEDPRSPDQTP
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTSLIQPEPQATNTKENQTTVKTTTNQITTVETKTTVAILKTNPKQQQQQQQLLVNFTPRLSTLDPHNQLLHQNPLRGLYALFWILLGFHIIATLHASGSLVIQSPLARLFSKHLPQLALVDLCLVASTFSALGFAKLLSNRYFDYCHTGLILQHLFQFSWLGAWILYIFYREWPWIQSGFLTLHSITMLMKIHSYCATNGEYSVQLKSLESKMKELKRSKVIEIKEDDQQHHKTLVSTVVKTGIYQKLQQFVDQKKEQPTTIDQSLGSNSQSDQGPEKPMNDEMMEQQVHETIDLLDQLGARNLRDSHDDDDQKEDQYSGQPWPENLTISNFTDYLLIPTLVYRLRYPRTKEIRIFFVVEKVFAVVGIFGLIYMITQYYIWDQVTNIKAFDRDHRSSALHLVDNVIRLVVPFTINYLLIFYIIFECICNAFAELTRFADREFYSDWWNSCSFDEFSRKWNKPVHHFLLKHVYASTISSYGVSRSAAAIMTLFLSSLVHELLMVIVTRKLRLYLFLAQMTQLPLTYIGRSKLFKTRPALANAFFWVGLISGFPLLAVWLVSP
The following text describes a protein:
Function:
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNAESCSLILSYISSAPAGNLVLNCTATTNKQTLEANLKSAVYQRYPEFLEDWTNVCVHIIHSYFPKDADYWNVDKLYTSVNRITTLEQSKVVGKEIKNGFTFDAENSTASLENDLQPQFRSHALFMVGSAGPLFSSTARTSRLDSRLPDGGIIAKPVALLPTPSVANSQEYTLDKLSPPSTAKPPASVIEFNPSLAKLPTVKYLQSGPFSSIAPYKNSSSSVIPDSSFHSVACYRASSHYKEAPVEKSIDIDIIQNNLSLLEEDSWTSVPIQGELVELNKLLQHLQLLQNQRITSHNVLSDEERQISVQVQNLILKLAKDYDMSPEDFLMDDFTLSLTQYGAFYRGTLPLSAQPLELPSQQLLRSQSNAALRSNSLSMNGSLSPSSTNVPLQSYRRTTKSRR
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MGQRGSRVSPVVASASDPPSPNPTERLSLVAPSAAVVGAGVAGVHVAYELAKLGFKVTVFERRGDIAGGETRFSLPFVGVGLIEPSLARTAFRTEVLRGMLFPTACPDLIAREHLFNTLLNPVVYRWMWGRLRSCFSDSEVMAYTNNLSCVSHSVVCELVNKYPHLHQHVFAGPVTVLNERKEAAVTAHAEPLMVDPVGWTRALAEVCRRDYDVQFALGERLEDAVTYLKYDVESTRSIRVSKPDPSHPEQRLFASEGYDVVILAAGASTGTMTLPNSRLPVLGLSGLSAVVQQPSGALKDAVWSLFQCRPHRSPAAAASSSSPEVDAPSSHEGVADPLARPAPGTLALLSSHCSLYGYTWPSSLTLSANRNGGPPSRSSAVASMMQSKVLPTPQDVVLQGLLSLDSTVKTKTHALVSRQLDRLESYLRIKCGWSVPLSSSSTSAEAGCGSNVVRVSEYVRAFTPDGVPIVDRNGGSFNCFVCCGFGDHAMDFAPGAAKVLGKLVEHQAQHLREEDIEKTKTWGLLTSKLSPSRRAAVEEELQLLFNGVDSDAVKRKGSRTPSEASALALLRHEDNPYSTNRFANMVRKEVKMDSSPPILSRLCALEDVFLTHLEPLRRRFHAKATELALRENTPDWLRTFVFCFMYEEDDDPAAQARKEQHVRSLQRLASQYETPVTDAKTTGDGAEELPLTPAEQSKRKQAELERRAREVFAKRV
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine.
Subcellular Localization:
Mitochondrion.
Sequence:
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALLALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGAVHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
The following text describes a protein:
Function:
Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
Subcellular Localization:
Cytoplasm.
Sequence:
MLACDLPEAGVRRVSALPTAAEPAGFWSGVAVWVDKPHVVNRRLTGAKEVARIWTNHRVISTMLQQPRVFAGLSEESLQKRLADMKMEGRNEAEGDDLELIIRDLLPRQLERAKVVREVVVLDHPRITAWFIPLGSSCHGDTESEQSYKSYRFVYSEDQTGKTIALDILSPPGVAAAHSPDRNCSTGGAAVHSPDRNCSTGGAAVHTAEDDRKCSPGGAAVHSAEDDGICSPTTKWLCDHLLPKIAKWSADVAPGGRRRVQALVPIDRYNIRYQQLKRKYGRRMMQVWPDVTTTDPEKFVYEDIAIATYLLLLWEEERSRLRLEEKQSFVDLGCGNGLLVYILAQEGHPGKGIDVRKRTTWDIFGQGTVLQEEPITPSDSCLFPDSDWLIGNHSDELTPWIPVIAARSSYTARYFVLPCCPHDFHGRFARTHTATSHYRNYLDYVCSIGQACGFTVEEDSLRIPSTKRICQIGRTRIYPEDEMQKIDKQISDFIISRPREQPKNPPKSQTERTGATTEFLQGGRNVFTDDPSADSKLTSDRRRSKVDGTTANGSALWVDGFQPRSKVELVRNCNRLEEGLKERIVNTVGLALLSQTGTASGAVLNQT
The following text describes a protein:
Function:
Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation (By similarity). Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKERIKDKAWRPQFIKLNNPDTSKKIVSQKSKKPEIVDLSSPGNNDLVTISILCVLLCFQLAISLNPHSGESQPPMYGDYEAQRHWMEITVNLPIEQWYLNGTHNDLLYWGLDYPPITAYHHYLLGVISNKINKKWVELTTSRGYESIAHKLFMRLSAIIPFYIFYLPPLIFYFTRSKKMSPILYALALLYPSLLVIDNGHFQYNSISLGLFLATYMFLTKNFTIIGSILFVAALNYKQMELYHALPVFVFILARSINKTQLFNSFRRILTIGLFVVGTFLIIWLPFLLTGTAKDVIIRVFPFNRGLYEDKVASFWCAFSFILKRLPLQSVQIYISTALVLAGSAPSLLVLFLRPTEKQFRISLTATGLSFFLFSFHVHEKTILLAAVPALLLISEYTSLVIWFLNITNISIFSLCVKDNFALSLSFFFAYFVVSYAYTAPRKISHILTILIGFAICILELYGPSNQRFPHIYQLANAFFSCVHFIYFLLYLSFASFEKTKKE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Sequence:
MAEVVQVHKDWVGSLPSGKKITVVFVIGGPGSGKGTQCAKIVSQFGFTHLSAGDLLREEVKSDTEQGAMIKNLMHEGKLVPSEIIVRLLLKAMLASGNDKFLIDGFPRNEENREAYEKIIKIEPEFVLLIDCSREEMERRILHRNQGRDDDNMETIRRRFEVFQQSTLPVIQHYEKMGKLRRVDGDRQPDMVFEDVKAIFAQLNTQANEGSNISRAQINPFKRWFLDLFCSCFDLQDRRN
The following text describes a protein:
Function:
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
Subcellular Localization:
Peroxisome.
Sequence:
MFATPLRQPAAANHQTPKNSAGMDEHGKPYQYEITDHGYGKDAVKVLHVSRNGPVHAIQEFEVGTHLKLYSKKDYYQGNNSDIVATDSQKNTVYLLAKKHGIESPEKFALLLARHFINKYSHVEEAHVHVEAYPWQRVCQEETRTNVNGKCENGVQGNCDFSSIDNRSLHNHAFIFTPTALHYCDVVIRRTDPKQTVITGIKGLRVLKTTQSSFVNFVNDEFRSLPDQYDRIFSTVVDCSWEYSDTENLDFLRAWQTVKNIIIRNFAGDPQVGVSSPSVQHTLYLSERQVLDVLPQVSVISMTMPNKHYFNFDTKPFQKIAPGDNNEVFIPVDKPHGTIYAQLARKNINSHL
The following text describes a protein:
Function:
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MLEEAGEVLENMLKASCLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQPYGTRNAVLNTEARTMAAEVLSRRCVLMRLLDFSYEQYQKALRQSAGAVVIILPRAMAAVPQDVVRQFMEIEPEMLAMETIVPVYFAVEDEALLSIYEQTQAASASQGSASAAEVLLRTATANGFQMVTSGVQSKAVSDWLIASVEGRLTGLGGEDLPTIVIVAHYDAFGVAPWLSLGADSNGSGVSVLLELARLFSRLYTYKRTHAAYNLLFFASGGGKFNYQGTKRWLEDNLDHTDSSLLQDNVAFVLCLDTVGRGSSLHLHVSKPPREGTLQHAFLRELETVAAHQFPEVRFSMVHKRINLAEDVLAWEHERFAIRRLPAFTLSHLESHRDGQRSSIMDVRSRVDSKTLTRNTRIIAEALTRVIYNLTEKVTPALPPVPQIQQEQLDSVMDWLTNQPRAAQLVDKDSTFLSTLEHHLSRYLKDVKQHHVKADKRDPEFVFYDQLKQVMNAYRVKPAVFDLLLAVGIAAYLGMAYVAVQHFSLLYKTVQRLLVKAKTQ
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MRRKCNLELTLSPSNLLMEDKRLENEQSQQLTIFYNGKFVASHVTQLQAKAIIYLASREMEEKTNKLSEPSSPLLQPQTVKKSLQRFLQKRKNRIQITSPYHH
The following text describes a protein:
Function:
Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MASSGSNSKSSMVNGTKQFALLPKIINGGIAGIIGVSCVFPLDLVKTRLQNQQVGPNGEKMYNSMLDCFKKTYRAEGYFGMYRGSAVNILLITPEKAIKLAANDFFRHHLTTSNGTLPITRQMAAGGLAGLCQIVITTPMELLKIQMQDAGRVAAQAKAIGKTIPKVSATSIAMELIRTKGITGLYKGTGATMLRDVSFSIVYFPLFATLNSLGPRRDDGSNEAVFWCSFLSGCAAGSMAALAVNPFDVVKTRLQALKKVEGEMQFNGVADCIGKTLKYEGVTAFFKGGLCRMIVIAPLFGIAQMVYFLGVAEALLGVKSGNK
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Miscellaneous:
MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MVELTITGDDDDILSMFFDEEFVPHAFVDILLSNALNEDQIQTQSVSSLLLTRLDFYTKNLTKELESTIWNLDKLSQTLPRTWASSRYHKEAEQNDSSLYSTESLKSSKLEYYLDTLASAVRALETGMHNVTEKLSDLDNENNRNTNVRQQLQSLMLIKERIEKVVYYLEQVRTVTNISTVRENNTTSTGTDLSITDFRTSLKALEDTIDESLSSAIDNEAKDETNKDLIGRIDSLSELKCLFKGLDKFFAEYSNFSESIKSKAQSYLSTKNIDDGMIS
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
Miscellaneous:
MISCELLANEOUS: Two forms, which differ in pI, are produced, S18 alpha and S18 beta.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MDKSKRPFIKSKRSFRRRLPPIQSGDRIDYRNMSLISRFISEQGKILSRRVNRLTLKQQRLITSAIKQARILSLLPFLNNEKQFERTESTTRTANFRTKNK
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MALSSRLLAACGAALLLLSLSVDAALNVNMKLASSRVTLTADALEVAVVVTPKQPKLKQLTLETLVDTSGASVLSGLTLKGDGSKFVTKLSGDNKLQAGMYKLKVSAVDEETKQSAYEVLQLKVTTPVNVASAKVNGKALKPGDKLSGQSFNAAAEDALKMEVALQQTHDKTPVAAHQAFLRFTHATEKTETYFVLTADKGLAHSTTLQFAALSKKFGYNSGKHHVELILGASTFEKAIVWDLGNVELQLGAAPPETPSPLYKKPLLYESDTTLKALPEIAHVMREQDPRPPVTVSMAFMGAVLAPFAFFLLFVARLGLNVKRLFEGSVFVFGCVFLASLGGILALFGFYWLELTMFRTLGYLSVLGSVNLWSGHLTLKRLAEAPAKKTTKVE
The following text describes a protein:
Function:
Component of the NatC N-terminal acetyltransferase, which associates with the ribosome to acetylate nascent protein chains in a cotranslational manner. NatC acetylates protein N-termini starting with methionine, followed by a hydrophobic or amphipathic amino acid, with amino acids at positions 3 and 4 also contributing to NatC recognition. The first 4 amino acids of cognate substrates are recognized at the Naa30-Naa35 interface. NatC-dependent acetylation targets various substrate proteins to specific subcellular sites (By similarity).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MENGEILLTSWLNRSVHIEIFDERKFIGKFLCTDREGAAILSNTTEYNKGFSRALGLVVIPGKHIKSFSVRA
The following text describes a protein:
Function:
Functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala) or Gly-tRNA(Ala). Has no activity on incorrectly charged Ser-tRNA(Thr), nor on correctly charged Ala-tRNA(Ala) or Ser-tRNA(Ser).
Subcellular Localization:
Cytoplasm.
Sequence:
MTEALYFLDCYMKEFEATVEKVTDDKFVVLDRTVFYPESGGQPSDTGKLVRESDGAEFNVLYVRKFNGDISHEIDGENVSNGLKAGDKVKGFIDWDRRYRHMRMHTATHVIANVIEKEAGAQITGNQLGLDQSRVDFSLEVFDRDKFAEYEKIANDLIAQKSPVNLYLVSRKEAEEKLSRLTTLAKGFSDEIKEVRIVEIEGVTIEACGGTHVKNTEEIKGVKIIKLQNKGKSNRRMYFTLVD
The following text describes a protein:
Function:
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MSAVESPVIVTEPGSLKPQGLTQTATGGKFGAAATVKTTPTKAKPYVKPQNANNLQNNFNPRKIFTEYISKEETDAGIEDGSMFKGVLRINPKNYQECFLDHPKGTNHPDVLVLGQDRNRAMQGDVVAVKIKPKEDWLVNYVEYVKWWAEHKKGDRNSGKTDNNSPNKTEKRCLRNEIQDNGVTSDEVPDSCLITIGAIVHILEKKHFRVAAGKLQLMPNSANPNVLFVATDSRVPRILIPKSDVDKEFFSRPKDFERFLYTAKITDWRAESVYADGRLVKLLGMSGEIDTETERIVYEHQIDHREFSDECLESLPITTAENWKVPDAEFEYRRDFRSDIVFTIDPKTARDLDDALHAKHIDDCDGKGTPGLEIGVHIADVTFFLKEGTELDKWASERGNSTYLSQTVIPMLPRILCEQLCSLNPGVDRLSFSTVFKMSYEAELYDVWFGRSVIRSRVKLAYEHAQDFIENPEKDFTCDELPDISDGNTPFEIKEKTLMLHRIAQVLRQKREDSGALRIELPRLKFALDEDKKPQGVSIYEIKDSNKLVEEFMLLANMEVAKKIAENFPEHALLRNHPPPKEKMIKDVAEQCARIGFPLDGRTSGLLSTSLRKYQGKSRLDMCIRQVISSLTIKPMQQAKYFCTFEMPLSFYHHFALNVDHYTHFTSPIRRYPDVIVHRQLAAALGYNERSERVPEEIQEICTRCNDTKLASKEASDESAMLYFGVFIHQTGPMKCQAVVLGVMDLSFDVLIVEYGVVKRVYVDKMKRDFNKSTEKLTIYWPADPNAESGNREEFSSSIQMCNVVYVILVPYKSIEVSATIVRPSLEQRNILKSTLKDMKETGSTILQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of trehalose 6-phosphate to trehalose and phosphate; prevents the accumulation of toxic levels of trehalose 6-phosphate.
Sequence:
MTETVTDQGKQRSSKLQKNEAAKDEQVEGKGKETLESGTDKSAEQNSSLLVGQPDVIDNDNVQTVDDFKNLMYKMQETRRAIVFALLNEKDLTKDDVEILKRAYEKLTDNQTHSFQREMCTLTTKLSVNIGDETRGLEKDLKYLDALMNIRREEPNLLWPIIMSRVDLFSILANYHPKGKETFLKEYEDTVKFLKTFISSEAITGKKPIFITDWDGTMKDYCSQYATNLQPVYSAVGMTRFAASFTRISAVLTAGPLRGPGILDLTAMPIDGPVMFSGSWGREWWLSGKRVVHQDGITDEGFNALQRLDDEMKDLLHTSDYAPFALVGSGVQRKVDRLTLGVQTVCHHVTSELSNRYQMAVKERMHRVDPNSQILVFDPSTELEVEVVAHNSGIIWNKGNGVERLIKSLGDSLQSPGKILICGDTLSDIPMVRQAVKQNPDGVLAIFVGAKMSLREEVKQVIGDESRCCFVSCPDVIHAAMSQILNEHCIGK
The following text describes a protein:
Function:
Salivary protein with anticoagulant activity that inhibits host thrombin (F2); binds to the proteinase in a reverse orientation (opposite to substrates).
Miscellaneous:
MISCELLANEOUS: Does not inhibit host coagulation factor Xa (F10), factor XIa (F11), factor XIIa (F12), kallikrein, chymase, trypsin, chymotrypsin, elastase, tryptase, cathepsin G (CTSG), plasmin (PLG), urokinase-type plasminogen activator (PLAU), tissue plasminogen activator (PLAT) and matriptase.
Subcellular Localization:
Secreted.
Sequence:
MASKLFVLAFLCLALVVVVQSAPQYARGDVPTYDEEDFDEESLKPHSSSSSDDGEEEFDPSLLEEHADAPTARDPGRNPEFLRNSNTDEQASAPAASSSESDE
The following text describes a protein:
Function:
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDIGTGKKEKEKKNRKGKDKENGSVSTSETPPPPPPNEISPPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKGLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKEIVAEAERLDVKAMGPLVLTEVLFDEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKTASVPKVETVKSDNKDDDIDIDAI
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity). This system is involved in N-acetylglucosamine transport.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Domain:
The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site; The PTS EIIB type-1 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain.
Sequence:
MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGTAVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIAGLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSFGEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPTAGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFAFMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVGICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQTIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAAVK
The following text describes a protein:
Function:
May play a role as physiological sensor for oxygen via redox signaling and/or electron transport.
Miscellaneous:
MISCELLANEOUS: Does not bind carbon monoxide (CO), nitric oxide (NO) or CN(-).
Sequence:
MGNQSTKSTHGTTRVSHSKSAHHNSSRVTSDVIPRSASAISSHERFFSDSQSSSPPAVCPVSAPGKYRNFPGKDVPPICLTDEYNNSDDEVFCSTRTSKQSPLATGCPRQNLGSPGNRRSVDSTNSDLLEAVTPRSHISVKRTVSSGTEHAPDHANMQKSSSLKFTRPGVRSETKETTPSTSSNPTMFPCIHQFLHLTQPQILFVRKTWNHARNQGALEPAISIFRNSFFKNPEIRQMIMFGTKNEGHERLKKHAQLFTVLMDDLIANLDSPSATVAGLREAGEKHVWPTRNQYGCPFHAHLLDQFATAMIERTLEWGEKKDRTETTQRGWTKIVLFVTEQLKEGFQDEQKRARRIKAQIKTSAGSSSFEISTKTKQSDMKRFHTLDNM
The following text describes a protein:
Function:
Required for microtubule function and cell polarity. Involved in the proper folding of alpha-tubulin.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MNEITLFIKSSSANAERRINPQWTVSQLKTKLVPIVGTPEQYQKLTYEPASSTVPGHVFTSEEENLDLGEFKLQPLGTIVVEDTRPPHLRLDFDDLSQVDKYVMPREQYENRTDSVYAWKKRNQLGRFNPDFEASKASRQESLKRELVDLQKNLNSRCCAAGERYGTIRYIGLVPEINNDNLWVGVEFDEPVGKNDGTVSGKRYFNAKNKHGSFLRSSEVEVGDFPPEDILEGL
The following text describes a protein:
Function:
Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycolipids such as GM1 gangliosides.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAKPFFRLQKFLRRTQFLLFFLTAAYLMTGSLLLLQRVRVALPQGPRAPGPLQTLPVAAVALGVGLLDSRALHDPRVSPELLLGVDMLQSPLTRPRPGPRWLRSRNSELRQLRRRWFHHFMSDSQGPPALGPEAARPAIHSRGTYIGCFSDDGHERTLKGAVFYDLRKMTVSHCQDACAERSYVYAGLEAGAECYCGNRLPAVSVGLEECNHECKGEKGSVCGAVDRLSVYRVDELQPGSRKRRTATYRGCFRLPENITHAFPSSLIQANVTVGTCSGFCSQKEFPLAILRGWECYCAYPTPRFNLRDAMDSSVCGQDPEAQRLAEYCEVYQTPVQDTRCTDRRFLPNKSKVFVALSSFPGAGNTWARHLIEHATGFYTGSYYFDGTLYNKGFKGEKDHWRSRRTICVKTHESGRREIEMFDSAILLIRNPYRSLVAEFNRKCAGHLGYAADRNWKSKEWPDFVNSYASWWSSHVLDWLKYGKRLLVVHYEELRRSLVPTLREMVAFLNVSVSEERLLCVENNKEGSFRRRGRRSHDPEPFTPEMKDLINGYIRTVDQALRDHNWTGLPREYVPR
The following text describes a protein:
Function:
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MAASGWGWGCDILIFYSPDAEEWCQYLQDLFVSCRQVRSQKIQTYRLVPDACFSSQDLSVFRDARCVLVLLSAGLVECFVQPGLLPVLQRACHPPQRVVRLLCGVQPNDEDFQAFFPDWAHWQELTCDDEPETYLAAVRKAISEDSGCDSVTDTEPEDERALPFSKHTDLPLETSPGNLMVVQPDRIRCGAETTVYVIVRCKLDEKVSTEVEFSPEDSPSVRMEGTLENEYTVSVKAPDLSSGNVSLKVYSGDLVVCETTISYYTDMEEIGNLLSSAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEDDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKSHIKEELMQGEEADDVYESMAHLSTDLLMKCSLNPGCDDELYESMAAFAPAATEDLYVEMLQASAGNPVSGESFSRPTKDSMIRKFLEGNSMKLASLEREQHPPHGEELYHTVEEDETFSVDLANRPPVPVPRPETSTPGPHPLPDNEPYISKEPLVRPWRDRPPSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKHADLEITVPIRHSQHLPGKVEFGVYESGPRKSVFPARTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEITRSRGPGPTQVDGAPVVTGTPVGILERPPRVPPRAASQRPLTREPFHHPPPPVPPRGR
The following text describes a protein:
Function:
Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNVAPGVTPDAPAPSAVSNRPDVKRDTHPFSRSQLEVLMTKRFFYIQSFEIYGGVGGLYDYGPTGAALQANIINQWRNHFIIEEEMLELDTTIMTLSDVLKTSGHVDKFADWMCKDTKTGEIFRADHLVEGVLEARLEGDKQARAIEAGQTAAVPAEAASGDSKKSNKKKVKSSAVKLDDALVDEYTSTLAQIDNFNGEQLGELVRKYDIRSPESGNEVSEPVEFNLMFESYIGPTGQIKGYLRPETAQGHFVNFQRLLEFNNGRVPFASAQIGKSFRNEISPRAGLLRVREFTMAEIEHFVDPEDKNHDRFDEVKHINVPLLAKDVQESGKTDITIKTIGEAVSAGIIDNQTLGYFIGRIYLFLVKIGIDATRLRFRQHMSNEMAHYASDCWDAEIHTSYGWIECVGCADRSAYDLTVHSKRTKKDLVVQKAHKEPKVYDALVPTIVKKNLGPKFKKDAKFVEEAILEMNQQQLAKLQRKLKNGSARLSICTGETYVLTTDVVTVEMKTIRETVREFTPNVIEPSFGIGRIFYSLLEHSFWTRAEDQDRGVLSLPPLVAPIKASIVPISSNEKLSPLVKQVSRKLRSAGVASRVDDSNASIGRRYARNDELGTPFACTLDFASLSKGTMTLRERDTTAQRIGPIDQVIDVIRQLCDGSLDWEGACKILPEYSGQQDVEG