lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity. The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition. Involved in several diverse cellular processes, including the functioning of acetohydroxyacid synthetase I, the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid , and the synthesis, translocation, or stability of cell envelope proteins. Activates transcription of periplasmic protease degP, probably by phosphorylating the cognate response protein CpxR; overexpression of an outer membrane lipoprotein NlpE also leads to transcription of degP via CpxRA. Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The periplasmic segment (residues 30-163) defines the sensory domain. Conformational changes in the cytoplasmic HAMP domain modulate the mobility of the central alpha-helices (which bend at Ser-238 and Pro-253) that allows formation of 1 kinase-active state.
Sequence:
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS
The following text describes a protein:
Function:
Negatively regulates the cuticle development by interacting with the HD-ZIP IV transcription factor HDG1.
Sequence:
MKAPNMETITESLEKSMMNCSLNDRRRRVVGDGFGRSSSNEHMTPISDRTLELNSHLSLPCHWEQCLDLKTGEIYYINWKNGMRVKEDPRKVMNADPDSGDSYGTVCSEEDSSYYDSEESSSESSPSSRENHKEEEEEEEEEEEEEEDVLVVAGCKACFMYFMVPKLVEDCPKCAAQLLHFDRPHSASS
The following text describes a protein:
Function:
Transcription factor which acts as a key regulator of pstA (prestalk-A) cells differentiation. Essential for ecmA-specific gene expression.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MDGYNQQQQQQQQQQQQHQMNLGSSGGILHSPQQQQQQQQQQQQQQQQPMNGSNNQLLGISNGGFGTMLQQSASLPINIQGSNSFSTFTPLSADDSNLKKRKIKNEDGTYSEIPYSPNSLVGSNGGLDSSFLMLQQQLQDQQQQIAQFNSSVNSPSFSLNSSQVNNNNNNNNNINNNNNSNNNINNNNSNNNINNNNNNNNNNNNNINNNNINNNNNYNNNNNNNNHNHLQTTTTTTTNNGLTINANNTPSQLSSSSLYPGIIPQISITNTQSGYTPRSISPNPSPNLSPTNSPIQSPHLPTDNYLMIGSENENSDPPSPMTQYNENPPFTWTDYKSEPWYTTFNTNGDEMPVPLLNIMASKGFSYIGGQWIYCRRNHFQLDITAVYPKLFQETQYGHNGVTLSNSSSSVDPTQTPSYMLISGVKTPINGLTLTIKGIKNRADMSQQESEVELFQTNSKREKQGEHAPKPVAIQFGSLVSIQRLHFRKATLNNARRHGQPNPHQEFNQLVVSLYGRCMGQEYCIVSYVSPALIVRTATQVTPPGDLSPVHTPDYAGTSSNNGGGSNNMNCFGPTISNIDFSTMNIVSPGHSPTSPRPLSQLTSQGQTNILRLTQNHNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNSNNNSLGNINNNNSNMLTSSSLLNGRINCFNNNINNNNNNQHNNNNQHNNNNNHHNINNQHNNQNNNNNNNNNNKCHWNSGDTEKSIVYNGKVGINVENPAYALSVQGTIYASEGVYHPSDLRIKYDLKSIDSKSNLDNVNRMKLYDYKYNPQWTHMNGRDPYLDNCDRGVIAQDLQRILPNAVRTIGNKNVNGQEIENLLVIKNEALVMETIGATQELSKQMDEMKLKLITYESKLKNLKKKSKNQTILLIIFMITFLLVALYMYKPSTHHSHHRRHNFDNNDN
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which seems to be clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. It also function in maintaining the identity of lytic vacuoles and in regulating the transition between storage and lytic vacuoles.
Subcellular Localization:
Endomembrane system. Golgi apparatus.
Sequence:
MASAMMESLFQRTLDDLVKGLRLQMVGESRYLAKALEEVRKEMKSTDPIIKVTALQKLTYLQMACGADMSWASFCAVEVMTMTRFSHKKVGYLAASQSFHEGTDVLVLTTNLLKKDLGSKNEYETSLAIECLSRILNADLAAALTPEVFTLMASSRSYIRKKATLVLLRVFVKYPDAIRVAFKRLVEKMDDADPQVVCAAVSVLCELTLKEPRAYLPLAPEFYRLLDKSSNNWLSIKLVKIFGALTPLEPRLGRKIAGPLCDLMRKVHAKSLLFECIRTVTLGLRDHTGAVKLCVEKLRENMDLGDPNLKYLGLKALAALMDSHPWALAESKEVIIKCLNDGDISIQRRALVLIMGMVSESNVVETVQVLLRYAQSADASFCNELLSSILQTCGRARYEIVSDFGWYVTVLSDIACIPHSEHGGEVGRQLMDVAIRVESVRTDVVRACCGLLADPALLGRPALQGALCAAAWIVGEHITRAPHGPYEVLEALLQPRTRLLHFSVHAVYLQTVLKVFVSYAISYQHRYFAKKEVLEQEEVVTQRGSLHAAVELIKENITPLMNSVDMEVQERACNVLGQLQPFEDPNDIHRVQDGFEMLTALSEVFSLDLGPVSVHAQGRVPLPENLLIENNLDALGPVCGSDDVLLNTGEAKTSTSYREWEAEFNFQPPSKENLSGVDPSSAALLQQHRHRYENFYLPSDAPVVDYPPAQLTLSAATTASTSHGPTDSSVFNENSLVWTKPRQAKARRPAVVALDDEDDLPGISTPVSKKGLKDELVFEAIRDALSADRNKGHSAADGLETPQGTSSSRKSGHGHRSTKNRDATNPRVDEIQIHAGDGVGQEADSQTPNVVHREHRRSRHHRPSKLEIHVINDGLSSENESEGTFKLSEKAHKKKHKHRSSHPRSRRPGKSPVSNSQNSGSIPDFLL
The following text describes a protein:
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2C is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The PDZ domain-binding motif is involved in the interaction with MPDZ.
Sequence:
MVNLRKAVHSFLVHLIGLLVWQCDISVSPVAALVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPVEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHVLRRQALMLLHGHVEEPPRINLDFLKCCRRNGTEEENSANPNQDSNPRRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLVMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKPEKKPPVRQMPRVAATALSGRELNVNIYRHTNEPVLKKANDKEPGIEMQVENLELPVNPSSVVSERISSV
The following text describes a protein:
Function:
Common component of the spliceosome and rRNA processing machinery.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTDAAVNPKAYPLADAKLTVSILDLVQQATNYKQIKKGANEATKTLNRGISEFIVMAADTEPLEILLHLPLLCEDKNVPYVFVPSKVALGRACGVSRPVIAASITSNDASQLGPQIQSMREQIEQLLI
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MDQITEVATETVVAVHFGVMTDEEIQKLSVVKITNRNILNMVGRPEPGGLSDPALGPSDDHSLCKTCGHRTFYCPGHFGHIDLVSLIYHPLLFDMLYRVLQNTCLACYHFKAPQEEVEMCIGKLNLIMKGDIVGARELGERPDDIDNSPPLDELSEGSNHQRGWTSFQLTEALSVLKSFLKRRPPKCNNCKAKNPPITKPTFGWFHMGGLNDNNIKQNIIRGHKLDGPFAEGDDDTSISEVEDDDAGQKASNRQRKKKDDLQLEFSKWKKPRSLLPTEVRGIVERLWENEAQFCSFICDIQQHQGFPSQKKAAFMMFFLKTLLVSPTKFRPPSKGGELVMEHSETVLLSKILDSNISLANAYEQHAEHNFILSRWMNLQQSVNFLFNSKNAAGPGQKDIASGICQLLEKKEGMFRQKMMGKRVNFACRSVISPDPYLAVNEIGIPPVFALKLTYPERVTPWNVTSLRQAIVNGPEIHPGATHYVDKITSKLPLIRKSRFSFARKLPSSRGVTTQHGKIFSNDCEGKVVLRHIRNGDIVLVNRQPTLHKPSIIALKVRVLPGEKTIRFHYANCDSFNADFDGDEINVHFPQDEISRAEGYNIVNANNQYIVPTRGDPKRALIQDHIVGAVLLTKRDTFLTLEEFNELLYMSGVGSYGASSFNANSGKKISVVDAEYVIQAYPPAIVRPKRLWTGKQVITAILNHITRDSLPFTAKKRAKIAREYFGKDESKSKNVEILSTADEVSQKKKKKSRTSKKEVVGDSAKSIRKDSEEKIESGMEKRMKGNSSHSIDEDIVFVYKNELVQGIIDKEQFGKYGLVHTVQEMYGANAAGNLLSVLSRVLTAFLQMHGFTCGVQDLLMEQPYDIKRRSLLDVCLNCGEEVHQQFIGHEKKHLDFLGMQIEIEKAIRRNGESGIALLDGMMRSKLNTLSSKVTKLFPEGLIKPFRKNCLSLMTLSGAKGGTFNFQQISLLLGQQELEGKRVPRMVSGKTLPCFVPWDCSARAGGFISDRYLTGLRPQEFYFHCMAGREGLVDTAVKTSRSGYLQRCLIKNLECLTVQYDYTVRDADGSIVQFRYGEDGVDVHQKNYMQEFEALALNQSLIVSKSPLSHTNDACLSTYVEEDNEVPNQLAKEAKEFFYNHALATDFQRTQPKGHLNFSKLVKNKYYKSLAQPGEPVGIIAAQSVGEPSTQMTLNTFHHAGRGEMNVTLGIPRLQEILMTASKAIKTPTMTCPLLKCKAKDDAEQLAAKLKRIKIADLIEKMEVSVVPFAIKKHEICSIYKLKIKLYDPELYPPHTDITLEDCHNTLIHDYMREMEAALKSHLLLLSRICGIKSDSQPKDSDEMDEAGFGSKSQTEGDDDGGDDDDEDDEEGGDQSSKTRKRKEQTTDEVDYEGDSEDEVEEGNHVSERENEVELGEDKDEDEDEDEDGKESLEQPSGPDSQEQKEKPETRQRKTSDDDKAIYVNCDELYFEVHFKLSGESHILMAQIAEKTAKKVYVKTAGKIEQCKVVELHLDDSGKGGIPMLRKGKESRAALQTAGVDFAAFWNMQDELDVKLISSNDVYAMLSTYGVEAARATIITEIFTVFGHYGVTVDMRHLTLIADYMTHTGSYRALSRSGGIIESISPFSKMSYETASKFLTYAAAHGEVDNLETPSARICLGLPAKVGTGCFDLMHDFDV
The following text describes a protein:
Function:
Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A.
Sequence:
MGFGDLKTPAGLQHLNDFLADKSYIEGYVPSQADIAVFEAVSGPPPADLYHALRWYNHIKSYEKQKASLPGVKKALGKYGPAELEDNTGSGGATDSKDDDDIDLFGSDEEEESEEAKRLREERLAQYESKKSKKPAIVAKSSLLLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFGDYVQSMDVAAFNKI
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MDWYNGFGIKPDLDQWISLDTLLQVIGEGNANVIVAICNPPRNSKTVVLRLAKESGINLKPLPFSVADQQAYQICATLSLFGQPFLPEMSLVSTTPALLSKIAASIISQRNSIRTYKNIDILQKSVMIMENTMIGSNDGRSRSFAIEIKTPQNNLKLFDNGMSVEFDQKCFGSSDAFIELIAQTLFDSSLLESLKDYQSAFHASPATVQDIIRQLSDDDKCTIDALLIEHCNEILKPTRNIPSCSITSIPFIFPSPIGETSNSKLNQLTTNQMRLIFRFLISMTLKDASIVLVFEANNRYEFYIQDCMTLILDV
The following text describes a protein:
Function:
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MENCGEVWPEGQCSLDASAAVRTTTITMERCAVLYSDVEDDPSLLTDNGMGARAPFHCSECDKSFRYRSDLRRHFARHTELKPFQCPHCVKSFKHSFNLVNHIRSHTGERPYRCTMCPKGFRDSTGLLHHQVVHTGEKPYCCPVCELRFSSRSSLGRHLKRQHRTSAAAAIPQAPVPRCLACGKEQSPLGHLCSAGRGRATPFGCGACGRHFQLASELRRHWLAHTDIKPFKCPECEKDFNAASLLERHKLTHVKGRPPPCPVCSEKVQQSDTVSEPPSLEAEPKGEQEEVKVLQHSSGCPTCRPPDASPPETLYQCDCGTFFANGNTLAAHLTAHGGEPSFTCGICGQPFVNLQILEEHQLSHAVSPSSMPGPGSELERHLLPQLDLRTFPSRPGKKLYKCSECEKYFRSPRDLDRHVLVHTGEKPYQCTECGKFFRHECYLKRHRLLHSGDRPFKCSVCHKGFITLSNLSRHVKLHRGID
The following text describes a protein:
Function:
Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.
Sequence:
MEAKAEEFSNEYAADISSIKEAQERISPYVYKTPVLCSETLDSISGRNLYFKCECFQKGGAFKFRGACNAVFSLTDDEAANGVVTHSSGNHAAALSLAAKIRGIPAHIVVPKNAPKCKVENVVRYGGQVIWSEATLQSREEVARKVLEDTGAVLIHPYNDGRIISGQGTISLELLEQIPEIDTIIVPISGGGLISGIALAAKSLNPAIRIFAAEPKGADDAARSKEEGAIVILPETNTIADGLRASLGTLTWPVVRDLVDGVIVVEDKEIIEATRLCYETLKVAVEPSGAIGLAAVLSESFRNNPVWKDCKNVGIVLSGGNLDLDMLWESLKSTV
The following text describes a protein:
Function:
Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as a leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Potential target of the RHO family members.
Miscellaneous:
MISCELLANEOUS: Each FH2 dimer contains binding sites for 4 actin molecules; MISCELLANEOUS: Present with 166 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Sequence:
MLKNSGSKHSNSKESHSNSSSGIFQNLKRLANSNATNSNTGSPTYASQQQHSPVGNEVSTSPASSSSFRKLNAPSRSTSTEARPLNKKSTLNTQNLSQYMNGKLSGDVPVSSQHARSHSMQSKYSYSKRNSSQASNKLTRQHTGQSHSASSLLSQGSLTNLSKFTTPDGKIYLEMPSDPYEVEVLFEDIMYKRNIFQSLSEDKQEALMGYSIEKKWLIVKQDLQNELKKMRANTTSSSTASRTSMASDHHPILTANSSLSSPKSVLMTSASSPTSTVYSNSLNHSTTLSSVGTSTSKGKKLVSGSLKKQPSLNNIYRGGAENNTSASTLPGDRTNRPPIHYVQRILADKLTSDEMKDLWVTLRTEQLDWVDAFIDHQGHIAMANVLMNSIYKTAPRENLTKELLEKENSFFKCFRVLSMLSQGLYEFSTHRLMTDTVAEGLFSTKLATRKMATEIFVCMLEKKNKSRFEAVLTSLDKKFRIGQNLHMIQNFKKMPQYFSHLTLESHLKIIQAWLFAVEQTLDGRGKMGSLVGASDEFKNGGGENAILEYCQWTMVFINHLCSCSDNINQRMLLRTKLENCGILRIMNKIKLLDYDKVIDQIELYDNNKLDDFNVKLEANNKAFNVDLHDPLSLLKNLWDICKGTENEKLLVSLVQHLFLSSSKLIEENQNSSKLTKQLKLMDSLVTNVSVASTSDEETNMNMAIQRLYDAMQTDEVARRAILESRALTKKLEEIQAERDSLSEKLSKAEHGLVGQLEDELHERDRILAKNQRVMQQLEAELEELKKKHLLEKHQQEVELRKMLTILNSRPEESFNKNEGTRGMNSSLNSSEKANIQKVLQDGLSRAKKDYKDDSKKFGMTLQPNKRLKMLRMQMENIENEARQLEMTNFAEFEKDRLEPPIHIKKPKVKKMKNKDRKPLVKPQEADVNKLNDLRRALAEIQMESNDISKFNVEERVNELFNEKKSLALKRLKELETKYKGFGIDFNVDEIMDSPKKNTGDVETEEDANYASLDPKTYQKKLDEINRITDQLLDIQTQTEHEIQVEEDGESDLSSSSSDDESEEIYQDASPTQELRSEHSELSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNNGSGIGPLHSKVEKTFMNRLRKSTVSSAPYLEELTQKVNKVEPYEQNEDEGLDKKSLPENSTASAASAFDKAEKDMRQHVENGKQGRVVNHEEDKTADFSAVSKLNNTDGAEDLSTQSSVLSSQPPPPPPPPPPVPAKLFGESLEKEKKSEDDTVKQETTGDSPAPPPPPPPPPPPPMALFGKPKGETPPPPPLPSVLSSSTDGVIPPAPPMMPASQIKSAVTSPLLPQSPSLFEKYPRPHKKLKQLHWEKLDCTDNSIWGTGKAEKFADDLYEKGVLADLEKAFAAREIKSLASKRKEDLQKITFLSRDISQQFGINLHMYSSLSVADLVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNLEDAKPPEKDPNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRKVDKAVSALQESDNLRNVFNVILAVGNFMNDTSKQAQGFKLSTLQRLTFIKDTTNSMTFLNYVEKIVRLNYPSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNLSDSSKFHPLDKVLIKTLPVLPEARKKGDLLEDEVKLTIMEFESLMHTYGEDSGDKFAKISFFKKFADFINEYKKAQAQNLAAEEEERLYIKHKKIVEEQQKRAQEKEKQKENSNSPSSEGNEEDEAEDRRAVMDKLLEQLKNAGPAKSDPSSARKRALVRKKYLSEKDNAPQLLNDLDTEEGSILYSPEAMDPTADTVIHAESPTPLATRGVMNTSEDLPSPSKTSALEDQEEISDRARMLLKELRGSDTPVKQNSILDEHLEKLRARKERSIGEASTGNRLSFK
The following text describes a protein:
Function:
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MRSDSGVQNLIPSPPRSRSPDFNLPSLNSGLGPQSLFPQTYSLESQTLPPDLESRSPAPSSLIQDSGFQFPSPTNPGVQTPQSLPSLDPESRSLALFFLGASCLEPGSFCFRPKHEEFQVPTTPPSRFPSAPQALLTHAQGSSSQMLCRHQRRRSGRRGFPVKSVQNLVPGRQSCSTGASSSGSESVGDPAPRILQDPTMGHPPPAVVWTWMFLLLLLEAWAGHLRAQESKVLGGQECEAHSQPWQTALFQGVRLLCGGVLIEDNWVLTAAHCKKRKYTVRLGDHSLKNKDSSEQEMAVAQSIPHPCYNGSNEDHSHDLMLIRLRGRASLGPQVKPINLADHCPEVGQKCTISGWGTVTSPRENFPDTLNCAEVEIFPQKKCKDVYPGEVTDGMICAGDSNGADSCQGDSGGPLVCGGVLQGITSWGSDPCGRPERPGVYTNICRYLDWIKKTIGGRG
The following text describes a protein:
Function:
Protein acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA), with a large spectrum of modified N-termini, including methionine, alanine, serine and to a lower extent threonine and valine as substrates, and epsilon-lysine acetylation (KA).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAALSISLAFSVDSLKPTQSTKFGFSSSSHRYPLLYSCKSHRSNLRFAFPPSSVSTATETGEENSKSTGNYAFLEESFRTGRFLSNDELEKLKTLEGFAYFQELESGSMWVRVMRHEEMDSTVHLLAESFGESMLLPSGYQSVLRFLIKQYLIERREVLPHAVTLVGFFRKKVDEFSDDGEEEAVMAGTVEVCLEKRGANASPPSPTPPKESPYICNMTVKEDLRRRGIGWHLLKASEELISQISPSKDVYLHCRMVDEAPFNMYKKAGYEVVKTDTVLVLLMLQRRKHLMRKKLLPLCTNPIVEMVGSDNELTSSANV
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage (By similarity).
Sequence:
MPHTKVAISLNSKTGVPLVFDLDDVRRIRGLGVLGTLCGSLPTAAQQNLFLTVPLRLMLEDAVWLVLSGHAYFSFDDKLLVQAAGSLTAAEVCRWRQDTERGLEQQRELRRREQQLKLAALHRTADETDTQRRLLEQSLFLETENCSKMIAAAEPAGLQLAILREMVAQHLDLGNYLIYRYLREEQYFLSAGGRFGARYVAYPGDPLRYHSHMAVQPAMDYYNESLDLLHVVGGGRLGTGVKKLWVVGGVRYREAEAAATAEEQIPPPDTLDRLLATSPPVSVFSIEWSGFG
The following text describes a protein:
Function:
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Sequence:
MEILIKGLRFLVTQDDERRILRDKDILIKEGIIEKIGNLRESADEIIDGRDLVAIPGLINTHTHIPMTLFRGVADDIPLFPWLNEKIWPMEANLRPHHIRAGTELGILESVRTGTTTIFDMYFFEDVIAEVFKEFGVRGVLASAIIDFGTPECKNFEECLKIADSFINKWINDPLILPCYGPHAPYTVSPSNLVEIASRTGSWIQIHVSETEGEVKDIKGKYGKSPVKLIEEVGVLSKRTVLAHLVWPDDEDLPIIANSGSLVSHNPISNLKLSSGIAPVPEMIEKGVRVSLGTDGAASNNSLDMFEAMKTAAIIQKARKMDPTVMPAQLILDMATRIPAEHLPWRIGRIVEGYEADIVLLNTKVPWWNPLHSVISHLVYSAKSTDVKYVLVKGNLLYDGSFRAKGEEKIYEEAEKSSIDLLEKSGVTSMLNSM
The following text describes a protein:
Function:
Involved in the endoplasmic reticulum (ER) protein quality control and unfolded protein response. May be involved in the quality control of glycoproteins. Forms a complex in the ER with ERDJ3B and MED37A/BIP1 which is required for the proper accumulation and function of the surface-exposed leucine-rich repeat receptor kinases EFR involved in pathogen-associated molecular pattern (PAMP) triggered immunity.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MALGFFCLAIFLYLSLDPDSGYTSASAAASGKEGVEITYGSAIKLMHEKTKFRLHSHDVPYGSGSGQQSVTGFPGVVDSNSYWIVKPVPGTTEKQGDAVKSGATIRLQHMKTRKWLHSHLHASPISGNLEVSCFGDDTNSDTGDHWKLIIEGSGKTWKQDQRVRLQHIDTSGYLHSHDKKYQRIAGGQQEVCGIREKKADNIWLAAEGVYLPLNESSK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MIPTEDASARKREIEEKLKQEQETLSFIRESLEKSDQLTKGMVSILSSFESRLMQLENSIIPVHKQTENLQRLQENVDKTLSNMDHVISYYHVAKDTDKIIREGPAGRLYEYLACIAKIQKAVEYFQDNNPDSPELNTVKARFEKGKELLEAEFRSLLTRYSKPVPPVLILDAIGGDEDMEVQEEVTLEHLPEAVLQDIICISAWLVEYGRNQDFMNVYFQVRSSQLDRSIKGLKEHFRKNSATSAIHSPAVQTKRKETPTKKAPKRPGKDDVLDIEIDSYIHCISAFVKLAQSEYALLTEIIPEHHQKKTFDSLIQEALDNLMLEGDNIVSAARRAIMRHDYSAVLTIFPILRHLKQTKPDFDATLQGTAASTKNKLPALITSMETIGAKALEEFADSIKNDPDKEYNMPKDGTVHELTSNAILFLQQLLDFQETAGAMLASQVLGDTYNIPLDPRESSSSASSYSSEFSRKLLSTYIYKVLGNLQLNLSNKAKVYEDPALRAIFLHNNYNYILKSLEKSELIQLVAVTVKKVESSYRELIEQEIQNYQRSWLRVTEHLAERNIPDFQPGAKLKDKERQIIKDKFKGFNDGLEELCKIQKGWAVPDKEQRDTIRHAQKRVVSLTYKAFLQRCANISFTKNPEKYHRYSPEQVEDMIDRLFDTSA
The following text describes a protein:
Function:
Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.
Sequence:
MNASPDSAKPPLDELIGRLSALHQKRIDLGLERMHRLLDRLGHPERKLPPVIHIAGTNGKGSTLAYLRATLEAADLRVHAYTSPYLVRINECFRLGRLGGGVLVGDDELRAALEEVERVNAGEPATVFELKTAAAFHLFAQNPADAVLLEVGLGGRLDSTNVVDTPAATVITPVSMDHTDFLGDTLTSIAGEKAAIIKRGVPVVCAEQSGEAMAVIEAQAKRMRAPLFAANESWHVNVEHGRLVYSDDRGLMDLAAPRLFGRHQFDNAGLAIATLRAISTFKVNQAAFEAGIVGAEWPARMQRITSGELLSWGPQGSEIWLDGGHNAEGGRVAAAALGDLEERVSRPLVVIAGMMANKDAQAFLANFAGLTRHIIAVPIPDTENAMPADRLADAARSLGMRVEPAPGIEAALRALSKLAYEVPPRILITGSLYLAGHVLGINGTPPA
The following text describes a protein:
Function:
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Sequence:
MPIATPEVYNEMLDRAKAGKFAYPAINVTSSQTLHAALRGFAEAESDGIVQISTGGAEFLGGQHNKDMVTGAVALAEFAHIVAEKYDVTVALHTDHCPKDKLDGYVRPLIAVSEERVKAGRNPLFQSHMWDGSAETLADNLSIAQELLARARAARIILEVEITPTGGEEDGVSHEINDSLYTTVDDAVRTVEALGLGEKGRYLLAASFGNVHGVYKPGNVVLRPELLKELNEGIASKYGQPAGSKPFDFVFHGGSGSTAEEIATALENGVVKMNIDTDTQYAFTRPVVDHMFRNYDGVLKVDGEVGNKKTYDPRTWGKLAEAGMAARVVEACGHLRSAGQKIK
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Miscellaneous:
MISCELLANEOUS: The porphobilinogen subunits are added to the dipyrromethane group.
Sequence:
MAPTPPSDTTRLRIATRESPLAMWQAEHVAKLLKKHGFQTEIVPLVSKGDTDMRPIDGTRQVGLFTKRIQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTGAESPLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAHAGILRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAERKVLSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADLHVAEAHELGTLVAKRLRDKGADKLISTVRENH
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MSASPPPPQGGTATSTVAAPPEDASQLSADDLLQHIVELVNKELERHYSLVEFDALGRIELLQVVNDIFAKLQPSMKMDMQATPPEEAMPRMLEFLLKILGYRVPVFVQGSFPQSFADGEPLVVYPTMYWILTHMELNEKRVYLARFLQPLDIPDDIRAQDEDVRTLFMQYQALRGAFIQTHQRVEKLRSACADPVETRRQVGVLEDERDRLQGYVEAALKKLAAVPEKEMLLAASKSLRMAREESTKLAEREVEQQQAKVSSEARRTEISTRLQNLRRDAADGRVEMMIRRMKDEMDTNRMKLQDQLPHELESVKNENAELQKLVSEPLDMAALTARDRKLDDELRALHAKIAQRQQPGADGASILRFRDQVQRVMARKQEVLNELSSLQADNNRAVNDIRERQLRITQLQSATNMLRSDDFRDFSNQVRAKKAATEGMRTRLAELRTEWGTLTFTEATLQEQYNALDAAIGDLESKLGLQGYSRTVEALSKLAHEKDAIEEVKGKTLEELSRVVQEFTLAIREGRTRLAPLINELRAVRQTAAEVDQEWSAKKSQYEYQESLLTEDIQKIDEDVTRLKEETTTSESLYHRVRTQGLLLAAQAKRAEEEQTFRTDRNASLDPQHKTYGDYLAEVTRTLEARTKEMQGKRRDLEETHDTSVRQVEWFNALRTILQAKLKSIQAEAPTAGARTRDTTIDDDIQQVMGRAGGTNMLVLNSN