lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Subcellular Localization:
Cytoplasm.
Sequence:
MFFDRVEIEFQAGKGGDGCMSFRKEKYVPKGGPDGGDGGRGASIVLEARLGVNSLAQFATRKFFRAEKGGFGMGALRHGRKGREMRLFVPCGTSIIDAKDGFVIKDLTQVGEEFVICRGGKGGHGNARFKTPQNQAPRERELGQPGETRHVIMELKSIADVGLIGKPNAGKSTLLSRISSARPEIADYPFTTKYPNLGIVDVDIERSFILADIPGLIEGASEGIGLGHEFLRHVERAGLLVHLIEPTPVDGSDPIQNYVAIREELQHYDESLADRDELVVMTKCELDPDGEVREQLQAYFDEHPANHARDLRSISAATDVGLKELVGEIMTRVAKRREEMIEAGITPTLIRQDDAPVTPKKERRLPPHKAAATGGLSDEVQAQDIQGAATLSDTGKVVPGERRDRSS
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Sequence:
MLLFCFQIMFSACELGVFDLLLESKELLSSAVIAERLGTSHPEMQRLLEACVGLKLLRMERKDNEGLFGNTDLASLCLAKSSPRTQYYFMKFLSDIVYPTSQYLTDAVREGKRQIQSAHATAANDLFGAVYSTEERLQRFSIAMGDAWCLYGQELLSAFDLSCFQVVCDVGGGNGTLAKEYISLYPKATVTIFDLPKVVEGAKKQSVASEECQISFQGGDFFKDPVPEADLYILARTLHDWDDDTCEQLLTKIYKACKPGTWYLNKRKHGQNRSTTCEALLGCRHCLVLTGALEDLLKG
The following text describes a protein:
Function:
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MKWNIGSSSASLQVPVDHTSATSIPSDHPPIPSSSSSRPPAQCPMHQADVSPPPAAANAPAKCPIQHDALDPTTHMPVNLSLSRQPDQKLDLPTERTASTIPRPSSAPGGEAYGTGNTWDYPSPQQFYNALVRKGWETPEDSVEVMVAIHNFLNERAWDEVMKWEKRLPGGDQSQLSRFQGRPGELSPKARFHLWAGKLFPSKFNTEPPFDRHDWVVTRRSPSSPQETVTARYVIDYYSAPPDEDGNPVFSLDVRPALDSLEAIKQRISVGVEEWLRGDVD
The following text describes a protein:
Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MALACLNSLNANAEIFSFDTRNSLNSDTLVLFHSADSTTYSLDFLPQSTQDQLNLAVADNSFSGKRGEVLEILVPSEIDAKRVLLVGIGDAKTLTPGEINALGGNIAAKLETVPQATVRVLTQGLNNAPLFGSELAHGIELRSYRYTQFKASNRVEKNYQIGVDDLSLNQKHHKNLQAVEAGVFLARDLTNAPAGNMYPESFANEARKLKSLGVKVTVLEAKDIERLNLGALAAVGKGSERPPKLVVAHWPGSKEAPIALVGKGITFDSGGYNIKATGTSIARMKSDMAGAATVLGTVKAMAIQKAPVNLVAIMPMAENMVSGHAMIPGDVITTAQGLTVEVLNTDAEGRLVLADGLWYARENYRPSVIIDVATLTGSKVSALGTVYAGLFTDSEPLVQQLTFAGQQVGEKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASAAAMFLKRFAGDQPWAHLDIAGHALTATDTAVVPAGATGYGVRLLSTWLTQPKAQN
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MFTGVINFNFTLPNPSLFTAEICYAAAPVALLMIAVYSISSKKNKKKKEEIIATEIVEEATVDDVRVLYKRRRSYDDEICWKSASDVLFEEDEEAIMLEADAKYAEELQVLKALQASQISTQRPSLSSFLMQVVCKICLEKHESWQMFTNSTCSHSFCYDCTAKHATTQIQSKRKTIACPGINCNSTLDSNMLRLIIPQETLIKWDEFLCESLIPESQKLYCPFTNCSVLLINDDTSNGVTKINCPVCRRSFCKVCRVPWHSELSCKEFGKLKGKTDDEMAVALAKKKKWKKCPNCNFFVEKAEGCVHITCRCKFEFCYTCGAKWSQSHNGCRRQNGVNIGN
The following text describes a protein:
Function:
Component of the elongator complex, a multiprotein complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitivity to Pichia inositovora toxin. ELP2 binds to microtubules. Independently, ELP2 may be involved in polarized exocytosis.
Miscellaneous:
MISCELLANEOUS: Present with 6090 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Folds into a two seven-bladed beta-propeller structure which is required for elongator complex assembly and association with microtubules.
Sequence:
MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLAYE
The following text describes a protein:
Function:
Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.
Miscellaneous:
MISCELLANEOUS: Present with 1800 molecules/cell in log phase SD medium.
Sequence:
MDDIITQVSPDNAESAPILQEQQQQQNSQYEGNEEDYGDSLIHLNIQENHYFITRDQLMSLPESLLLCLFPSGVFLDRCGQVITNLTRDDEVYIVNFPPDCFEYIMEIYTKAHDDLYNHPVEKFFDRPSSSFVSNAKGFFGLSSNNSISSNNEQDILHQKPAIIVLREDLDYYCVPQEEFQFDSTNEENNEDLLRHFMAQVKMAAGSYLTSKTSIFQGLYSSNRLKQQQQQQKIEKGSNSSSNTKSTSKKLGPAEQHLMDMLCSSGFTKETCWGNRTQETGKTVISSLSLCRLANETTEGFRQKFNEAKAKWEAEHKPSQDNFITPMQSNISINSLSASKSNSTISTARNLTSGSTAPATARDKRKSRLSKLADNVRSHSSSRHSSQTRSKPPELPKLYDLVPKPNINAKLLLFWRKPARKCWWGEEDIELEVEVFGSWKDESKKIIELILPTNVDPEAELHKIIVPVRLHIRRVWTLELSVIGVQ
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MELNTTDKQVHTRRFSSREIEVISGLLAGFSTTIVTHPLDVIKIRLQLSRDTPKTTHPLESIISVIKKINQDAKVAYKLNHKPKAFNYLIQYYRGITPNLIGNISAWGIYFALYAEFKSKVKTNNTTMNYFASSVLAGLSTSIITNPLWVLKTRILGSSRNESNAYRSVTDGIRQMLAKEGITSFWKGTIPSLFSVVQASLQITIYDHIKVYLSSPHHKSESIGATSHLSTWQYLYSSASSKIISMLILYPTQVVRSRLQYSQDSSSSIVSIVKELYYKEGGLKGFYKGIGANILRVLPATCVTFVAYENVKRYLM
The following text describes a protein:
Function:
Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Sequence:
MNALFLQAVSQYQYTALPQEGFHLEHESAVVPSKRIIDVGYDLTVVGVYKRPTKLTTMFETFVSVEIPLGFYAEIVSRSSICKTGYMLANNVGIIDPSFTGTLKVALIKVDESMPDLTLPASVVQLIIKPYVVTEAYVMDKKHITTRRGCVSTTISEITPEWEALGFSCKEEYEWYLRDQAVLEVWDAYQCNQDYITDGGEDSDSDDNEDEYVDEYAEILEERFEAQYAHDTRYGYDSDDDDDESDDEVGETWVRMAFVESNSESDDGYYDSSDYEE
The following text describes a protein:
Function:
Electron transfer subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from the membrane-anchored tetraheme c-type NapC protein and transfers these to NapA subunit, thus allowing electron flow between membrane and periplasm. Essential for periplasmic nitrate reduction with nitrate as the terminal electron acceptor.
Subcellular Localization:
Periplasm.
Sequence:
MKSHDLMKALCQWMATLALVVSGAVWAANGVDLSQSPEVSGTQEGAIRMPKEQERMPLNYVNQPPMIPHSVEGYQVTTNTNRCLQCHGVESYRTTGAPRISPTHFMDSDGKVSGNVAPRRYFCLQCHVPQSDTAPIIDNTFTPSQGYGK
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MEKEPKVANEDPKVDLFEDDDEFEEFEINEEWDDKEEGKDTTQQWEDDWDDDDVNDDFSLQLRKELENNAEKS
The following text describes a protein:
Function:
Probably a component of the fimbrium tip. These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. They play an important role in invasion of periodontal tissues and are major virulence factors. FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response.
Miscellaneous:
MISCELLANEOUS: The name (major fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
Subcellular Localization:
Fimbrium. Cell outer membrane. Note=Probably synthesized as a palmitoylated precursor. Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide (Probable). Probably part of the fimbrium tip, as a part of the complex formed by FimC, FimD and FimE.
Sequence:
MRTNRILNIICPPILFLLVGFLFGCVREDIESDMNETSSLFLQVQPYNQRSEEGGVAAYDENTIERLTLVFYKNGTKVWQAEPVETSPSSNSYYVPVPESMYGQFNGNNSFKIYLVANVNFSGSFEPNASETSFLKTLVPNSILLQNDGKPEDKFAMIGSVEKQINMATSEGKQLGSIELKRVAAKLRLKKPVLNISDYELVGDPKAKFRNCMPKGFLSVEEKPEGVGYEAIDYRPMTEANSSVHFYSYYNEWALNNEGRPEFVMMLKLKKTGTDDNTAKPYYYRIPVDGSDKKIRSNHLYDMAVTIEVLGSLNEEDPVTINGSLSVIEWTSHSDDQTLPDVQYLEVIPQETVMNMTTEIELDYFSSHSLLPPADVKATCTYVNSNGQQITDTYTGANVPTVTIDANTKKIKVRSILPINNIPKDISFTIKNSIGFEKKIKIRQNPSQFIINTFGTKSSWQPEGNLAPNLNNKAIYQIVVLSPPADGNMIIGFPPTKEVGFYKKSGSSYTLKHTDRITEQDEQTANMVSPSFELASQLGATLVQDHWEYYTLNPLRLIYHSNQQNRYALMTCAFYWEERKKADGTIERLDDWRLPTRAEIQLVDKLQREQAGVVRDIMTGRYYWSGLPDKAIKILLPTASGNATEQRAHVRCVRDVKNDRFVKSAKRLKK
The following text describes a protein:
Function:
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSLSALTYIARRGMATKLTVNNLAIIGSGQMGAGIAQVAAATGHKVVLCDTAGDILEKAQAGIQKSLQRVVKKKFADDPEKGQAFITSTMANIETTTEPAKAVVTADLVVEAIVENLAVKQELFKTLDKFAPAKTIFASNTSSLPITAIANSTQRQDKFAGLHFFNPVPVMKLVEVVRAPGTSQAVYECLMDFSRALGKHPVTCKDTPGFLVNRLLVPYMMESIRLYERGDGSKEDIDVAMKLGAGYPMGPFELLDYVGLDTCKFIMDGWHELEPDNPLFQPSQLLNELVAAGKHGKKTGEGFYKY
The following text describes a protein:
Function:
Involved in the secretion of alkaline protease.
Subcellular Localization:
Cell outer membrane.
Sequence:
MTMRRLMTWLFGAFLLLLREDAFALGLLDGYHLALENDPQFQAAIQEHEAGRQYRALGRAALLPRLVYSYNRGRSWSDVTQTTTRGDFKEDRDYDSYVSTLSLQQPLFDYEAFSRYRKGVAQALLSDERFRSQSQELLVRVLEAYTGALLAQDQIELARAQKRSYREQFQLNQRQFERGNGTRTDTLETQARFNLAQAQEIEARDSQDAALRELERLVGAPLEIADLAPLGERFQVRPLSPASYTAWRDLALAENPELASLRHAVDVARYEVEQNRADFLPRLGLYASTGKSKSGSENTYNQRYETDSVGIQLSVPLFSGGETLAATRQATHRMEKSHYDLDDKVRETLNQVRKMYNQSSSSAAKIRAYEMTVDSARTLVMATRKSIAAGVRVNLDLLNAEQALYSAMNELSKAKYDYLTAWARLRFYAGVLDEADLELVAANFVSGETPARRRDCATTDCPAPLHTLSKTDTEENRSALN
The following text describes a protein:
Function:
Promotes neuronal cells survival to stress conditions.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MWPAPCSVGRLLIFFMCSSSGYVVQGCGPSPGARTTLGSPLSLWSIKTPSHIFCTRRAINLGFPSPPLVQLIFWSLNAGLDLYLCLISSCGFSQVFWPVEAFCSFSLSFFALALSHKFVICRLDQHIFSGFTKSLKNLPPCHRTDI
The following text describes a protein:
Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sequence:
MGAAAAEEAVVVVRGAPPPPSSGKRRSTTLLHLFQLEKPDVVVGAMLLPPPSPEPEEDRLITKIESCSRVFTFVDGGGAAGGESGEERDAKTEALGEVLAAVRASGKRKQGLDHRVMVALVKMVAANLFRAMPPSAYPSSLPPPSDVLDDEVPVMVLLPSWPHLHLVYDVLTAAVAAADARALRNHVDRSFLAGLVTLFASEDPRERDRLKTAYHLLYSKLTGERAFMRRTMAAALLRFVYDASPAEAERHCGVGELLEVCGSIINGFAVPLKEEHRAFMARVLLPLHRTRWVHTYHRQLAYCVLQFVHKDPGLAGAAVRDILRHWPATNCQKEVLLIDELEEIVEILDQHHFDKLVVPVCSRIARCVSSCSSQVAERALYVWNNERFVAMACAAGPAAMEERILPAFVASMEANLERHWSRCVQQVTASVRALLDRVAPGAYARCAAGLAARLAEADADAAARRARWRRLELAADAGADAK
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAASSSSSMASSQPRMMEQSLFYTQPPARAVHTRKVTAVNLHREMSLIRSLMPTFPFVAVDTQFPGVVHPHPRGAGVTADDRYAAVRANADELCLLQLGITLSAADGRLPVDGALVEFMWDFDFAGFDARYHRHAPESVQFLRAQGFDFEAARLAGVPALAFAAELAASGILGLRGVTWVAFGGMYDVAFLLRLATGGAPLPATRLGFLAQVGAVFGTQVFDAKHMASLLHMHGGLAAVGGMLRLPPQLPRRHMAGQNSVMAIQLFMELRRRFNDLGGSLHSCSLKIEGLT
The following text describes a protein:
Function:
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MERVQHMTKSAIRRASQIEVNPQAKRNLQELFVNFTLILICLLLIYIIVLLSS
The following text describes a protein:
Function:
Required for osteoclast and melanocyte maturation and function.
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein. Note=Requires CLCN7 to travel to lysosomes.
Sequence:
MARDAELARSSGWPWRWLPALLLLQLLRWRCALCALPFTSSRHPGFADLLSEQQLLEVQDLTLSLLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAELTACMVRSARPVRLCQTCYPLFQQVAIKMDNISRNIGNTSEGPRCGGSLLTADRMQIVLMVSEFFNSTWQEANCANCLTNNGEDLSNNTEDFLSLFNKTLACFEHNLQGHTYSLLPPKNYSEVCRNCKEAYKNLSLLYSQMQKLNGLENKAEPETHLCIDVEDAMNITRKLWSRTFNCSVTCSDTVSVVAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQENAT
The following text describes a protein:
Function:
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
Subcellular Localization:
Cytoplasm.
Domain:
The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
Sequence:
MVDGFEVGAVHFNSEGWGPPDATVTPTTTSTLPLNVPYAPFSRSEKLGRIADFTRILNPGSGQDGGGGRKSAASDSVFDFTADDSFPSGADNDSTFRLVDGKPPPRPKFGPKSRFNQHHRPQLPQRRDEEVEAKKREAEKERARRDRLYYLNRSNQNQQRREAAVFKSSVEIQTEWNMLDKIPFSIFTKLSFSVSEPEDMILCGGLEFYDKSFDRITPKAERRLERFKNRNFFKVTTTDDPVIRRLANEDKATVFATDNILATLMCATRSVYSWDIVVQRVGNKLFFDKRDGSQLDLLSVHETSQEPLPEAEDDINSAYSLSVEAAYINQNFSQQVLFRDGNKVSFDEPNPFANEGEEVASVAYRYRRWKLDDDMYLVARCEVQSVVEVNKQRSFLTLNALNEFDPKYSGVDWRQKLETQRGAVLATELKNNANKLTKWTAQALLANADMMKLGYVSRVHPRDHFNHVILAVVGYKPRDFASQINLNTSNMWGIVKSIVDLCMKLNEGKYVLVKDPSKPQVRIYEVPADAFENDYVEEPLPEEEQAQPPEENAENTEANGVTNDVEDKEIGAQA
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MNDFGIKNMDQVAPVSNSYRATLKRQPAFDTLDGSLLSVFPPLNEEQTLQEVPTGLDSISHDSTNCELPLLTPCSKAVMSQALKATFSGFKKEQCRLGIPKNPWLWTEQQVCQWLLWATNEFSLVDVNLQRFGMTGQVLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEEQYEENSPLNSVPQWINSNSLGFGVEQTPYGVQTQNYPKGSLLDSLCPASSAPSTLGPEQDFQMFPKARLSTVSVNYCSVSQDFAGSSLNLLSSSAGKPGDHDAPENGADSFESSESLLQSWTSQSSLLDVQRVPSFESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
The following text describes a protein:
Function:
In mitochondria, S-adenosylmethionine-dependent methyltransferase chaperone that supports both coenzyme Q biosynthesis and NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) assembly.
Miscellaneous:
MISCELLANEOUS: PIGY is derived from the same bicistronic transcript that encodes these 2 different proteins.
Subcellular Localization:
Mitochondrion.
Sequence:
MLAVRAWGRTYNTLVQRKLNAACPTGALPAVTLRPLHCSLVARSPEQSLKDSKTFDPTLLQFLVCPLSRKSLRYEESTNELINDELGIAYPIVDGIPNMIPQDARMIHKDRKPESPDTEQTT
The following text describes a protein:
Function:
Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing; Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MATPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIKVIEDIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWETFKKKPDHFPFFFKCILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQPARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQERRFLSQLIQKFISVLKSVPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDDSHLLVHCYLSNLVHREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVDTRESLIKFFGPLSSNTLHQVASYLCLLPTLPKTEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYETFNIIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQISTLDFNDTFLSIEHLKTSFPGHNVKVTVDDPALQIPPFRITFPVRSGKGKKRKDADGEDEDTEEAKTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSNQFFLRLQCGSIFCLLIYGSWVWIALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYISKVKNKSNTLPDVTEVSTFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGSNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTSRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHHYHQTLLQLPPAMVEEGEEIQSQETELETEEEAMPVQADVPSLTDAGSSQEASASQTETTPSQTETTPDQTGAGSNPETLSPPSESTATMVGPEAAAAEADTPQDTTSAAEETK
The following text describes a protein:
Function:
Part of the Sec61 complex, which is the major component of channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. Also part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein ER import.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MARASEKGEEKKQSNNQVEKLVEAPVEFVREGTQFLAKCKKPDLKEYTKIVKAVGIGFIAVGIIGYAIKLIHIPIRYVIV
The following text describes a protein:
Function:
Chromatin-associated protein which contributes to the modulation of chromatin structure (such as super-helical structure of DNA) and function. Binds to chromatin of protein-coding genes throughout the genome to regulate nucleosome occupancy and chromatin accessibility, and to modulate the expression of target genes. Negative regulator of stress tolerance (e.g. high salt).
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Associates with chromatin. Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei (By similarity).
Sequence:
MGEDTKATIEPTANKTTSLEKPSEAMAGKENAGGKETQELAKDEDMAEPDNMEIDAQIKKDDEKAETEDKESEVKKNEDNAETQKMEEKVEVTKDEGQAEATNMDEDADGKKEQTDDGVSVEDTVMKENVESKDNNYAKDDEKETKETDITEADHKKAGKEDIQHEADKANGTKDGNTGDIKEEGTLVDEDKGTDMDEKVENGDENKQVENVEGKEKEDKEENKTKEVEAAKAEVDESKVEDEKEGSEDENDNEKVESKDAKEDEKEETNDDKEDEKEESKGSKKRGKGTSSGGKVREKNKTEEVKKDAEPRTPFSDRPVRERKSVERLVALIDKDSSKEFRVEKGRGAYLKDIPNVANKVMRKRSDETLKLLHPILFGGRRGKAAQIKTNILGFSGFVWHGDEKKAKEKVKEKLEKCTKEKLWEFCDVLDIHITKATTKKEDIITKLFEFLEKPHVTGDVTGDTTVSEKEKSSKGAKRKRTPKKTSPTAGSSSSKRSAKSQKKSEEATKVVKKSLAHSDDESEEEKEEEEKQEEEKAEEKEEKKEEENENGIPDKSEDEAPQPSESEEKDESEEHSEEETTKKKRGSRLSAGKKESAGRARNKKAVVAAKSSPPEKITQKRSSAKRKKTDDDSDTSPKASSKRKKSENPIKASPAPSKSASKEKPVKRAGKGKDKPSDKVLKNAIVEILKRVDFSTATFTDILKELAKEFTEDLTPRKSSIKMIIQEELTKLADEEEEEEKKEEDSEKEEAGGSGGGEEVKA
The following text describes a protein:
Function:
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Sequence:
MQVGYQRKRRRPVAEINVVPYIDVMLVLLIIFMVTAPIVTQGVKVELPQGAAEVLPADSKPPVVASIDADGAYFLNQGGSNNEEMELEELATAVAAIMVTEPQRPVVVKADRTIPYDNVIQLMVTLQQAGVPSVGLMTDSPKEK
The following text describes a protein:
Function:
Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWRRTYLLLLLVRVYFALSPSYLHPDENFQGPELFAGRTLSYPSKLPWEFTSENPIRSVFPLWPVYSLPMGLLKWFYVELEIGNPSPEVAYYSLRAVMFLLSFVLEDWAIYELVPLPRHRRAAVVLVASSYVTWTYQTHTFSNSLETLLVTWGLVLIRRIAGQKRRSSVFSCVVLALITVAGVFNRITFPAFLLIPGLQLLPHFWRRPTSLFVFVLWGLFFSCTAIIIDTRFYRPSASVLDALRSPIITPLNNLLYNTKTSNLALHGLHPHYQHFLINLPQLLGPAFVAMILSLWNRPAIPSWLKTTQAVSALSGTAMLSVFPHQEPRFLIPCVPLLLSCFRLRKSRLFIVAWVIFNVALGFLMGVYHQGGVVPVQLAIPNIISANTLKSNKSLENQPRVSATVLWWKTYSPPSWLLGNNTNFPLDIDTRDLMGIPGAEMAQELEQLVPPCSSHSGTHMDDASAGSGRADRTNFVLVVAPRSATYLDQYTTAAAGSSGLELQELYSYPQHINMDDLDVGTDGLLATLKRVFGRRGLNVWLARRAGCD