lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MMSSLEYEVVSVLETLIHSTVNEMSTILTQTTADESVSMEFTDQLNSVLEHNAKEAVKKICQIFSALLHHDISPSAQETRPKQVEQWQKAHLEVTDLPDIDLYRSYSTDQLSVVSADKIAVVVSWNGEEDVHTKHVKTPTKIQKMVILADETLVDCSESGDHPQFVLLQDSDSVEEEQNTNSPDTQDGAIESVSSSVSKSADAQSSRRKKDKPFSCEHCKRTFESPILLKAHQVVHVKSEKTFICSQCGRRFGSKDTLDVHYQLHTDNSPYVCNKCGKIFTEHKQLQSHQRVHNEDRTFICKVCGKSFNQAYGLRKHLVVHSTEKVHKCDVCGKSFHFRNNLLRHQRIHTGEKPFTCQTCGRSFNQLDTLKAHKLTHTGERPYKCKMCNKGFVQKQILRLHEGEHEGEGGYSCFICDMLVGCKNSLQTHLAVHEGQTPVVCLVCGESIVSTLKSHQHNALKTQQYKAMKLRQHNALTSQQRKHTITTKFSCSLCGKFCRSFAGLNLHKMIHTGEKPYSCSECGKPFRQKNSLKTHQTLHTGERPFSCVECRKSFHTLANLRRHERIHTGEKPFKCGICERKFNQSNSLKAHMHIHTGEKQYVCDKCGKSFAYLRNLKSHKCLQV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase. PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity).
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Domain:
The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.
Sequence:
MTPSTPADDAWIRSYQRLLPESQSLLASRRSVIPVAISRVNQFDAARLDVEMSAMLKEQLVKVFTLMKPGMLFQYEPELDAFLEFLIWRFSIWVDKPTPGNALMNLRYRDERGVVAQHLGKVRTGLEGPGLTSPQKIWYCVASVGGQYLFSRLQSFSAFRRWGDSEQRPLARRLWTLVQRIEGIYKAASFLNLLSFLYTGRYRNLIEKALKARLVYRSPHMNRSVSFEYMNRQLVWNEFSEMLLLLLPLLNSSAVKNILSPFAKDKSSSTKEDTVTCPICQVDPAIPFIALPCQHRYCYYCIRTRCASAASFRCLRCNEPVVAIQREGVSSGK
The following text describes a protein:
Function:
Plays a role in intracellular enveloped virus (IEV) transport to the cell surface on microtubules. Together with protein OPG056/F12, forms a complex that interacts with host KLC2 (kinesin light chain isoform 2) to engage the kinesin-1 complex and thereby promote IEV trafficking.
Sequence:
MISVTDIRRAFLDNECHTITKAFGYLHEDKAIALIKIGFHPTYLPKVLYNNVVEFVPEKLYLFKPRTVAPLDLISTITKLKNVDKFASHINYHKNSILITGDKSLIVKCMPYMIISDDDIRFIREQFVGTNSIEYILSFINKESIYRMSYQFSENEIVTIINRDHFMYEPIYEHQVLDSDFLKTMLDRYGIVPINSGIIDELCPEAIIEILMAVVRPRDAIRFLDIVNKNQLTEDSVKNYIINDIRRGKIDYYIPYVEDFLEDRTEDLGIYANIFFEDAIDITKLDITKTELEHISKYMNYYTTYIDHIVNIILQNNYIDILASIIDYVQDVLTEELCIRIVCESTNPVPVTSLPIHSTLVMVMCIQMKYVDIVEFLDEIDIDTLIEKGADPITEYTFTTRWYNKHNDLITLYIKKYGFCPMMMKRLMFEYPLTKEASDHLLKTMDENRGAIMFFPRTICTLPYLLCCNYKLIQKPIPFKEENRNIVYKKNNRVLCFDSLENSAFKSLIKIDSIPGLKTYNMKDITYEKSNNIICVRFIPQESIHNEERRIKLQLFDIARLASYGLYYIPSRYLSSWTPVVNMIEGREYTNPQKIECLVILDLFSEEFIEYQNLGNAVSNKYELEYTISNYQAAINCLMSTLLIYLVLGSIRSISRTENFVLSILNIFYKGLKINELLSEPVSGVCIELNKIKDRASSGDSSFIFLKKNELSKTLSLCEKVCVETILDNNQSFKSSK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MAAESSAAAAAGGGERRGPMDLNLYLGLPPLPPPPGRLDVAADYPSLLLNSAATVANEQRGSVVVAAPPPAAAAYSPSNALSAPEQVLVDPVAAWLVDPGEQQPVPPLETPSYMARASSTLPQIFACAALEMLVQTGGAIPPTGLIRGAEIAAASRPMTPENRLRRLIQVSDQHGVGNGRAGTGPVSRSRRANSPEADNLARAIQRSHNSLEASRRQMLDGDGSDATKKDDGCGCNGSFECNICFESAKDPVVTPCGHLFCWPCIYQWLHGHSEHSDCPVCKGEVLEVNVTPIYGRGGGEENSSRNDIQIPPRPSAQRTESLRQQLQRPDTRGGIANMVRRLMQNQDIVVGQAASSAPRPRGRGRRQARQDAPSAPATQQQVVNADAGSGNQAPLPPPDANGAAPAAAVAPQQSSSVEQASTSSTVGVIAGGPAQGRRSRVSESTPARRTRRRHQ
The following text describes a protein:
Function:
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSKVLKSLLLTALLGVTGLISGCGDLTVLNPKGPVAKGQSDLIIYSIIFMLVIVLTIFVLFTIMLVKYRERKDISNYEPDMHGSKKLEIFWTLIPVAIVIALAIPTVKTIYAGEEAPKVTSHKDPIIIYATSADWKWIFSYPDESIETVNYVNIPTDRPVLFKLTSADTMTSFWVPQLGGQKYAMSGMTMNLYLQADEVGTYKGRNANFNGEGFADQRFDVVAQSEKDFKKWAKETKASSPVITQDIYDRLLIPGSSKKKTYSGTHLAFVDVAADPEYVFYAYKRFGYEMTNPHNPNTKSTISDEPMLPVRPVTVTNPQFERHDMKPQIIKNGEGYHEDKHREDEMKKMEEDIQTNEFNKKESDDAGK
The following text describes a protein:
Function:
Converts the D-glycero-alpha-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
Subcellular Localization:
Cytoplasm.
Sequence:
MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARALKKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHRSQRCGCRKPRPGLVLDWLRRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIGGASSGGVADASFDSLWEFAVAVGHARGERG
The following text describes a protein:
Function:
Vesicle SNARE required for retrograde transport within the Golgi complex.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MNDQNERRLETLSGQVSSLKNVTYDIYSRANDYTRIDRATESFSGLSNSVKKSTENFFRVVRSAGRRRIMTMVLAIVGSILIIYYASKWFF
The following text describes a protein:
Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. Regulates IRS4 levels by directing its degradation via ubiquitination and thereby decreases the downstream signal of IRS4 (By similarity). Also acts as a negative regulator of GPS1, a component of the COP9 signalosome (CSN) multiprotein complex, thereby inhibiting the serine phosphorylation of IRS1. Plays a critical role during early vascular development and proper placentation. Mechanistically, negatively regulates the transcriptional regulator inhibitor of DNA binding 2/ID2 expression through polyubiquitination and proteasome dependent degradation.
Subcellular Localization:
Cytoplasm.
Domain:
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Sequence:
MDGITAPISKAGAAKLVKKDFLEALKTNDFGKLKAILIERQIDVDTVFEVEDENMILASYKQGYWLPSYKLKSSWATGLHLSVLLGHVECLMVLLDHNATINCRPNGKTPLHVACEIANLECVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVLRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVENGAIVDSMNAHMETPLAIATYWALRFKEQEYSREHHLICRTLLDNNAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNIKWRRAIPDDDLEKHWDFYHSLFKVCCNTPRTLMHLSRCAIRKALHNRCHKAIPMLSLPLPLKKYLLLEPEGIIY
The following text describes a protein:
Function:
Together with EMD, contributes to nuclear envelope stiffness in germ cells. Required for female fertility. Essential for normal erythropoiesis. Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side. Nucleus envelope. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope.
Domain:
The transmembrane domains are required and sufficient for its oligomerization.
Sequence:
MAGGIKVSVWSAVGPGPRCWGAGGGGGATWLLLVVAGCVVCGSADVNVVMLQESQVDMNSSQQFCYKNVLIPKWHDIWTRIQVRVNSSKLVRVTQVDNEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEMIEKDTTYSVTVTRRFDPKLFLVFLLGLTLFFCGDLLSRSQIFYYSTGMSVGIVASLLIVIFMISKFMPKRSPIYVILVGGWSFSLYLIQLVFKNLQEIWRSYWHYLLSYILTVGFMSFAVCYKYGPLENERSINLLTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYPIHWLCSTYRRMCKASGKPVPPRLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSFHLTPNEVSVHEQEYGLGSIFTQDEELSSEEEGSEYPTFTQNNFLT
The following text describes a protein:
Function:
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Subcellular Localization:
Cytoplasm.
Sequence:
MRFSVVETFHGHRGRLGNICGLRIGTGEQCLDTPTCLLYTQAGSAPHLTRDMLHKLGDVENLPALFPLPPITSFVDSVMQFGKGLGSFVALQSHPSFIRIQDPMVTTPSGFNDKAGVSVWDQGGRVHLNPLSFTRMMEAFQPTCYQALCDSDTPQDASRKRLQRAVDRSVSLLDQCLAMKADSSCLQHSAILGSVQGGYNRDFREISAKETAKRDVDGFVIEGFHVNGPQTKSLKFEEVAEILEEVIALLPQDKPRFLHGVLRPEFILKAVLYGIDIFDASLAHAATEAGCALVFNCSSDKDLELMLGRDLLDQELEMDMKNARHREDFVPLLESCACYACTNFTRAYIHHLLNTGEMLGQVLLSLHNIHHFLGFLKSIRKFMVQHGAKELNGN
The following text describes a protein:
Function:
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
Subcellular Localization:
Nucleus.
Sequence:
MSSNRYDEEDETEEQSREARFRRQRDEDEDDEEDEEEEEEEDDEDHERGVQKHPKKRQRRQKANPFIDYEAAVDEDDEEDDEEAEDGFDREEAEEVERTFHDESRHRAFDRRVQQEEDTNAEAIAERFKQRYGRSEMSRGAYRGDLDHVPQSVLIPSVNDPKLWLIRCKPGKEKIIVMQMMRKFDDLELTSKTPLEILSVFSRDSLQGYVYIEAMKQAHVMAAIQGVNNIYVSKLQLVPVNEMVDCLSIKGKTLDLKTNAWVRVKRGRYDGDLAQVLEVAESGDTALVKLIPRLEPARGTLGQVQSRRKKGTDVRQPQKLFQPSDFNKREINAGNGGYTYQGDFFDKDGYLEKTMKVTSLLTEMVNPTLDEITKFSGGSINEQNNDLALLASANQATTDDFQIGEGITVISGELKNVPGVIQSIEGGIVTVIPDKSFGLSGPLRYPARDIAKRFEEGNHVKVVGGVHKDETGLIVKIDNNVVTILSDTSLNPISVFSKDLRTASEVSAVGTSLGQYDTLDLVQLSASDVGVIVKIEKDILLILNQYGNLLRVKPQQIQSKRDSSRAVTSDSHARPVTAGDHVVVSDPSSTIKRSGTVLHIFRSHVFVKSREIVEDNGIIVARNSNLVVMGGKVPMPAFGSHAPGAGRGNAYNPYAASTGLAGQGRSGGPGGMGRGRGRGRGRDEFVGKTVTICGGPYKGYLGIVKDATETHARVELHTGNKTINMEKTKLSMHGAESRSMQSQVNAGYNGYADRYDRNSNMGSRTPSYSGSKTPMYRSNTESATPNPHMDGGRTPAWDSGSRTPAWNASSKTPAWEASSRTPARPDSFFPGADHMPYQNALADNADTPYIPSTPAVDGMHGQSHNVTGTPGAYPSTPAAHNLPQTPLGGIGGQYPNMGSVPNTGLPQTPFVPATPFNPSTPANVHGDYYGSPNGGMDVHVSENWLCVGIEVRIIQSQTGRRFRDGQYDGRRAAIKTVEQGNRNAQILFLDGGVDGHGGEVISGVPDECLGPIHPEKKEAFKVLKGEYRDYTGVLLSIDMEEGVVRLDGRSDILMMDMSSLAKIHASSE
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MMEVESSYSDFISCDRTGRRNAVPDIQGDSEAVSVRKLAGDMGELALEGAEGQAEVGTSDKEASSQPESSDGTTSS
The following text describes a protein:
Function:
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular Localization:
Nucleus, PML body.
Sequence:
MQQGDTSIKPVLQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNALVEGGQLASNCVCQVHRFIVNTLKDGRRVVILMDLEVVKSAGEVGVKIGNPVPYNEGHAQQQAVSAPASAATPPASKPQPQNGSLGVGSTVAKAYGASKPFGKPAGTGLLQPTSGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSIELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFSAVKNDYEMTFNNETSVLPCEDGHHLPTVQFDFTGIGDLESKSKDSLVDIIGICKSYEDATKITVKSNNREVAKRNICLMDMSGKVVTATLWGEDADKFDGSRQPVMAIKGARVSDFGGRSLSVLSSSTVLVNPDIPEAYKLRGWHYVFGDGGLKALLHRQAHDPLMNLESQRKQLELKCCVLTLIPPGRQGFNSCVLESSAESISGLRCGQLMWGFDSEGQALDGVSISDLRSGGTGGSNTNWKTLYEAKSENLGQGDKADYFSTVATVVFLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDREFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNTVYLGELKEKVGCVFVSMNEQAFEEVFQNANFRSFTFRIRVKLETYNDESRIKATVIDVKPVDYRDYSKRLIMNIRKNI
The following text describes a protein:
Function:
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
Subcellular Localization:
Cytoplasm.
Sequence:
MSSSPLLNGVLKPNAKSIYEQRKKYSNVIMADVSQYQVNHLVTFTIGEDDDVHTVEDAIRKLNAVDAKGKIWMQEMLIEVNSSLVKLLDLNSKEVLEEFPLSAIQRCDTVLPERRDQPLLILVCQDKYQPKPDVYFFQSDNVAAHLIKEDINSAVSDFQTGVNAKRPEALRNNKEQIAQSTTGPNTFTPLGQWKQPTSQYVTPAEILEREAQRKPMVKPPRSSLTPKITVNSHDQGQQSVETPQNSQEPLYSEINRSDIPQQFIMESGSPQMQQKISKVAEETAMDPSAFRSGHEVDLLNHCFDDIEFFMGSLQKSAEAFRMLNQRKKSRRTKKKEAGEGLLTLRAKPPKIEEYEDAVQKFKYCFCLLARLKNNIVNPSAVELVHFLFGPLRTLVDSCGGVEMPSEMTSPMLTKEAVTFLKESLNDQELELWTSLGPNWTKPRVEYPREYSQPYIPTFRGGWVPVSTNGKPWEDPIELQHRHEELRAQQSAPQVNIPAAIPAVNGHEETETKHVSCTYDFVARNSSELSVLQGEVLEVIDDTKKWWKVQNRFGQIGYVPYNILAPYTAPDANKAKVNGSQQSSPGKVVPPTPPKKPSNGSGRNSWNQANGLNQEQINEQGKMERISSMNEELLLRLANGRTAPQKNLNIQKMPDTSIPLTDESSPAEVTAWLQAKGFNTLTVNSLGVLNGVQLFSLRKDEFRAVCPEEGARVYSQVMVQKALLEDSKKISELEAVMERQKKKVDTNGQ
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRIVGRFPSKNLQTKSRRILEFKLYKSVRCYSKDVCPPPPPKRKDKSSSGALYTLGALALVGGATIGYAKYDPDFRKTLGEYVPWTDDVIKFVFQEEHSLLDSASGVYEDVKKSVSGLLTQEQRKKKEDVKLEQKQYKAPQPVIPALEDTKVPQEGYTEIRIEQKDKRDVEIGGEAKVPPGEVSVPESHPSNLAELEAKICDAATEAVNFYNKAVYDLRVYNGEISQILDQSVDQVKPPQWEALKAKTKAKNESVRLAEEKAAQAAQNVSKLKTLLTKTSAATKEMVNINIDKVQEDIDAAKAQYEIERKLGSITDKYWEKVQKARHHFCEELESLFPAIDIYNKKLEVNEADLDLFILHAYSVVLYYQKELAKLETVAHEKLQSALDAARRGGFEPLGKAQICEAIEEEKRKLTLCFQKQCLKLRKEAEHELREQLKRQSQVFADHLDEAVTTRALEIERVLSRKFDEEMEKERFKHKSQLAAMVGRMKGLDHAFKARDAADKAAKQSQVLWAACQALLRAIKTGCPGIPWKDQLRPLSPEITLVQKAAAKGDELVEAVINGIPKEAKERGVFPEDALRERFLKVEDVARRVALVPEEGGALPLHILSYIQAFFLIKNPSPIPQAELNDEAVDFSQLSTNEILQRARYWLDRGDFAQTLKYMNLLQGAPRSIARQWMNETRILLETQQAANTLMAHAASSGLLHL
The following text describes a protein:
Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGEIRVTRDFFLWSMSVIYLSAFASLYHQMPGLYGDRGILPVRSVVPVDTNPRAAQQKAHQLPTLLWLAPNFGLKVSTMMEFLGLLGILMSFIATIWSRFRDCINFALLWILYFSLYQVGQTFMWFQWDILLLEVGFLCILVAPLGMFQRTLGLSSSWRLPHNPHDKVSVWLLRWLLFRFMFSSGVVKLTSMCPAWWGLHALNVHFESQCIPTPVAWYFHHLPEWFLRLGVVFTYVVEIAVPFLFFVPVRSLRIFSFYCQVLLQLLILVTGNYNFFNLLTLALCLSLVDDEYLLNAVGRSTFYRKSLMRTTRRVLAKTASLLTLCCLTFATVKLFQVQLYPDWTFGCRIAFTPKQFEELLAKTMPVTIWMGAASLAVTILLSLQRSFFSLNQYTVLQEDDKCMAEERHNGGNAACRSLFEERGLLRKLFSTCGTVLCSTAAVWLFCVSLVPFSTLDYNLHSKLWPVVRQWHSKVEPFHVASSYGLFRRQVLASSPWPPVSLVAGQVLVFNWRFSPSLRVGDIFLARRMTGLEGRPELVLEGGDQPTGPWKELPFLYKPGNVTRSPPFVVPHQPRLDWQMWFAALDRYERNPWLLSLVHRILTGQEQVLALLDREHYPFAKQPPKYVRGLLYTYRFTQFNAKSRVPNVNDWWKRSKPTEYLPPLHKEQPFLRQFLEKAEIPMDSPKLRSRNGFLKPILAKSRELANAMSPTVYVWSFITSAMVLKLVGTLL
The following text describes a protein:
Function:
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Sequence:
MTKVTREEVEHIANLARLQISPEETEEMANTLESILDFAKQNDSADTEGVEPTYHVLDLQNVLREDKAIKGIPQELALKNAKETEDGQFKVPTIMNEEDA
The following text describes a protein:
Function:
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF (By similarity). Promotes synapse formation.
Subcellular Localization:
Secreted. Cytoplasm. Cell surface. Synapse.
Sequence:
MKTGSLTQRGALLLLLLLAPAVTPTWYAGSGYSPDESYNEVYAEEVPDTRALDYRVPRWCYTLNIQDGEATCYSPRGGNYHSSLGTRCELSCDRGFRLIGRKSVQCLPSRRWSGTAYCRQMRCHTLPFITSGTYTCTNGMLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKIAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPILKPPQHGYLTCSSAGDNYGAICEYHCDGGYERQGTPSRVCQSSRQWSGSPPVCTPMKINVNVNSAAGLLDQFYEKQRLLIVSAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSAGIIEELRQFQRLTRSYFNMVLIDKQGIDRERYMEPVTPEEIFTFIDDYLLSNQELARRAEQRDVCE
The following text describes a protein:
Function:
Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity).
Sequence:
MNFRRLKYFVKIVDIGSLTQAAEVLHIAQPALSQQVATLEGELNQQLLIRTKRGVTPTDAGKILYTHARAILRQCEQAQLAVHNVGQALSGQVSIGFAPGTAASSITMPLLQAVRAEFPEIVIYLHENSGAVLNEKLINHQLDMAVIYEHSPVAGVSSQALLKEDLFLVGTQDCPGQSVDVNAIAQMNLFLPSDYSAIRLRVDEAFSLRRLTAKVIGEIESIATLTAAIASGMGVAVLPESAARSLCGAVNGWMSRITTPSMSLSLSLNLPARANLSPQAQAVKELLMSVISSPVMEKRQWQLVS
The following text describes a protein:
Function:
Probable transcriptional regulator that acts as a histone acetyltransferase. Mediates the acetylation of histone H3 and H4 of target loci (e.g. FLC). Involved in an auxin-independent regulation of shoot branching and flowering time.
Subcellular Localization:
Nucleus.
Domain:
The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.
Sequence:
MEPTDSTNEQLGDTKTAAVKEESRSFLGIDLNEIPTGATLGGGCTAGQDDDGEYEPVEVVRSIHDNPDPAPGAPAEVPEPDRDASCGACGRPESIELVVVCDACERGFHMSCVNDGVEAAPSADWMCSDCRTGGERSKLWPLGVKSKLILDMNASPPSDAEGYGAEETSDSRKHMLASSSCIGNSFDYAMMHSSFSSLGRGHASLEASGLMSRNTKMSMDALGSHNLGFGFPLNLNNSSLPMRFPSLDPSELFLQNLRHFISERHGVLEDGWRVEFRQPLNGYQLCAVYCAPNGKTFSSIQEVACYLGLAINGNYSCMDAEIRNENSLLQERLHTPKRRKTSRWPNNGFPEQKGSSVSAQLRRFPFNGQTMSPFAVKSGTHFQAGGSLSSGNNGCGCEEAKNGCPMQFEDFFVLSLGRIDIRQSYHNVNVIYPIGYKSCWHDKITGSLFTCEVSDGNSGPIFKVTRSPCSKSFIPAGSTVFSCPKIDEMVEQNSDKLSNRRDSTQERDDDASVEILLSEHCPPLGDDILSCLREKSFSKTVNSLRSEVDSSRVDFDKNLSYDQDHGVEIGDIVVEEDSLSDAWKKVSQKLVDACSIVLKQKGTLNFLCKHVDRETSEINWDTMNEKDNVILSLSKFCCSLAPCSVTCGEKDKSEFAAVVDALSRWLDQNRFGLDADFVQEMIEHMPGAESCTNYRTLKSRSSSSVPITVAEGALVVKPKGGENVKDEVFGEISRKAKKPKLNGGHGVRNLHPPPGRPMCLRLPPGLVGDFLQVSEVFWRFHEILGFEEAFSPENLEQELINPVFDGLFLDKPGKDDKRSEINFTDKDSTATKLFSLFDESRQPFPAKNTSASELKEKKAGDSSDFKISDSSRGSCVGALLTRAHISLLQVLICELQSKVAAFVDPNFDSGESRSRRGRKKDDSTLSAKRNKLHMLPVNEFTWPELARRYILSLLSMDGNLESAEIAARESGKVFRCLQGDGGLLCGSLTGVAGMEADSMLLAEAIKKISGSLTSENDVLSVEDDDSDGLDATETNTCSGDIPEWAQVLEPVKKLPTNVGTRIRKCVYEALERNPPEWAKKILEHSISKEIYKGNASGPTKKAVLSLLADIRGGDLVQRSIKGTKKRTYISVSDVIMKKCRAVLRGVAAADEDKVLCTLLGRKLLNSSDNDDDGLLGSPAMVSRPLDFRTIDLRLAAGAYDGSTEAFLEDVLELWSSIRVMYADQPDCVDLVATLSEKFKSLYEAEVVPLVQKLKDYRKLECLSAEMKKEIKDIVVSVNKLPKAPWDEGVCKVCGVDKDDDSVLLCDTCDAEYHTYCLNPPLIRIPDGNWYCPSCVIAKRMAQEALESYKLVRRRKGRKYQGELTRASMELTAHLADVMEEKDYWEFSAEERILLLKLLCDELLSSSLVHQHLEQCAEAIIEMQQKLRSLSSEWKNAKMRQEFLTAKLAKVEPSILKEVGEPHNSSYFADQMGCDPQPQEGVGDGVTRDDETSSTAYLNKNQGKSPLETDTQPGESHVNFGESKISSPETISSPGRHELPIADTSPLVTDNLPEKDTSETLLKSVGRNHETHSPNSNAVELPTAHDASSQASQELQACQQDLSATSNEIQNLQQSIRSIESQLLKQSIRRDFLGTDASGRLYWGCCFPDENPRILVDGSISLQKPVQADLIGSKVPSPFLHTVDHGRLRLSPWTYYETETEISELVQWLHDDDLKERDLRESILWWKRLRYGDVQKEKKQAQNLSAPVFATGLETKAAMSMEKRYGPCIKLEMETLKKRGKKTKVAEREKLCRCECLESILPSMIHCLICHKTFASDDEFEDHTESKCIPYSLATEEGKDISDSSKAKESLKSDYLNVKSSAGKDVAEISNVSELDSGLIRYQEEESISPYHFEEICSKFVTKDCNRDLVKEIGLISSNGIPTFLPSSSTHLNDSVLISAKSNKPDGGDSGDQVIFAGPETNVEGLNSESNMSFDRSVTDSHGGPLDKPSGLGFGFSEQKNKKSSGSGLKSCCVVPQAALKRVTGKALPGFRFLKTNLLDMDVALPEEALRPSKSHPNRRRAWRVFVKSSQSIYELVQATIVVEDMIKTEYLKNEWWYWSSLSAAAKISTLSALSVRIFSLDAAIIYDKPITPSNPIDETKPIISLPDQKSQPVSDSQERSSRVRRSGKKRKEPEGS
The following text describes a protein:
Function:
[Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions; [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.
Subcellular Localization:
[Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands; [Junctophilin-2 N-terminal fragment]: Nucleus. Note=Accumulates in the nucleus of stressed hearts.
Domain:
[Junctophilin-2]: The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, by interacting with phospholipids. Has affinity for phosphatidylserine, and phosphorylated phosphatidylinositols including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P2 and PtdIns(3,4,5)P3; [Junctophilin-2 N-terminal fragment]: The bipartite nuclear localization signal (bNLS) and Ala-rich (alanine-rich; ARR) regions are involved in DNA-binding.
Sequence:
MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPTLPLPPVPRGGFALSLLATAEAARPPGLFTRGALLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRRVLPLKSNKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPRERGPGTGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGSSKDGLLSPGAWNGEPGGEGSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSREPEVALYRGYHSYAVRTGPPEPPPLEDEPEPEPEVPRSDSEPPSPVSATVQEEESPAPRSRVPAKPATLEPKPIVPKAEPKAKARKTEARGLSKAGAKKKGRKEVAQEAEAEVEVEEVPNTVLICMVILLNIGLAILFVHLLT
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome.
Subcellular Localization:
Cytoplasm. Late endosome. Lysosome.
Sequence:
MVTPLTGTHEGVSCDGCAFTAFAGNRYKCLRCSDYDLCFSCFTTKNYGDQQTIADIPIHDESHPMQLILSSVDFDLVYQGDPTRHYDERKIVSFTCPYCNITGLTERQFGTHVLSQHPEAPGYSVICPLCIGNTEMEHIQSKETENLSVHWTEIHLHTMENLFRSTEPITTRPVQRRPMLARRGNRAGVSRTAAQGRPLQDEIGAEMAALLRNMGPDSVEDIRRFTEMMTVPLLPGIRSSQRLMTSTGDRPTVVVESAVTHQDPNVQQVIRPLATIPIYPPTSDESGDETPQPAADSADESEDDNDIQELDDMQPIVEDEALKKDEFWKTLKTRISEEDVDLILETMKSTAKVKEDIDDKMPVWTQRPLKRLANAAQVTTTSDSEGDPGWLPLSFETTPIRSTGCGGYWSDKRFLRPRKMQREQSVASSNAEIMEKAEIALALIRASCLHEPVFTDPTKPDIALKEALQHLRLGEKPAKMMEYQAAEELVNMPERDPITTGEMEVEIPDFTARGYGQIVDGNIPLGVVPEADEAITNSEDEEIVGGETSGDDEDEQEDDENDSQDSSVPEEINID