lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities. Involved in RNA processing, required for the IRE1/RLG1-dependent splicing reaction of HAC1 mRNA.
Miscellaneous:
MISCELLANEOUS: Present with 4150 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSANSPTGNDPHVFGIPVNATPSNMGSPGSPVNVPPPMNPAVANVNHPVMRTNSNSNANEGTRTLTREQIQQLQQRQRLLLQQRLLEQQRKQQALQNYEAQFYQMLMTLNKRPKRLYNFVEDADSILKKYEQYLHSFEFHIYENNYKICAPANSRLQQQQKQPELTSDGLILTKNNETLKEFLEYVARGRIPDAIMEVLRDCNIQFYEGNLILQVYDHTNTVDVTPKENKPNLNSSSSPSNNNSTQDNSKIQQPSEPNSGVANTGANTANKKASFKRPRVYRTLLKPNDLTTYYDMMSYADNARFSDSIYQQFESEILTLTKRNLSLSVPLNPYEHRDMLEETAFSEPHWDSEKKSFIHEHRAESTREGTKGVVGHIEERDEFPQHSSNYEQLMLIMNERTTTITNSTFAVSLTKNAMEIASSSSNGVRGASSSTSNSASNTRNNSLANGNQVALAAAAAAAAVGSTMGNDNNQFSRLKFIEQWRINKEKRKQQALSANINPTPFNARISMTAPLTPQQQLLQRQQQALEQQQNGGAMKNANKRSGNNATSNNNNNNNNLDKPKVKRPRKNAKKSESGTPAPKKKRMTKKKQSASSTPSSTTMS
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNHIETRLPLPIQPIDRWLRPFARFLHIEATSGLVLILCTVVALVAANSSWADSYLAFWHTDLTIAVGDIVFHHSLHHVINDGLMAVFFFVIGLEVKRELAHGSLSDLKQATLPIAAAIGGMIVPATLYLSMQYGQPGVQGWGIPMATDIAFVVGCLAILGSRVPHSLRVLLLSLAIVDDIGAILVIAIGYTESLDGRYLFLAAVAVGAVHFLSRIGVRRFPPYVIVGVLAWIALHESGIHATLIGVILGLMTPATPTLVPERFREYLHEKEHEFQPKEWSRRLHRAEVVREVQQLTRETVSPLEYLEVTLHPWTAYVIMPVFALANAGVLIEPANLSDSVAIAVVIGLVVGKPLGIALFSWLVIRLGVARLPSGLNWPILMSGSFLAGIGFTMALFIDGLAFGADGLDTAKTGVLVGSAISAIAGMGLLLWTLPKPTRQ
The following text describes a protein:
Function:
Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus. Begomoviruses use 2 proteins to transport their DNA from cell to cell. The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall (By similarity).
Subcellular Localization:
Host nucleus. Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocated to the plasma membrane by the movement protein BC1.
Sequence:
MYSTKYRRGFLANQGRGYPRHSTGKRSRNVSRIDFKRRSSKYVHGNDDSKMANQRIHENQFGPEFVMVHNTAISTFITFPSLGKTEPSRSRSYIKLKRLRFKGTVKIERVHVDLSMDGPSPKIEGVFSLVVVVDRQPHLSPTGCLHTFDELFGARIHSHGNLAVSSALKDRFYIRHVFKRVISVEKDSTMIDLEGMTSFTNRRFNCWSAFKDFDRQACNGVYGNISKNAILVYYCWMSDIVSKASTFVSFDLDYVG
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MFSKNWALMAVFSFLVICLVTTMAAHAEVDPGSASGFPFLLRYGYYDDKCEDLEDIVWSKMKTIVQLQHNAPAQLLRLMFHDCFIGGCDASVLLADRNENGTVEREAIPNRTLKGFNFIDTIKDEIEEECPGVVSCSDILVLATRDGIVLAGGPYYPVLTGRRDSKESFFDKAMAEIPQPNGNIIETLRLFSLRGFDERETVALLELRRKCPDDNNTISNMLNDEHTDTARGLSVSIATSLDNHYYKTLMRGRGLLFADQQLMANEKTAAAVTDYAIDDGIIFRTEFAHAMGKLSNFGVLTGSEGEVRHSCSHLNS
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
Subcellular Localization:
Nucleus.
Sequence:
MDPTGLQNRLSGGKRRKDVYSGEEEVIHESHKISRRWIPGRADDNVEKDNLNQALDYRPMSADHWMRLQQQKLEPAAPTTPLNTPMNLQQRAMTVASLHDMRNIESSKQIMHPCQTPQTLASSQPQQHQQQHQQQQQQQQQQQQQQQQHQQQQQQQQQQLQQQQQLQQQQLQHQQQLQQSSQHTNQLANGVQPLKYQHQQLEAEQMQMHMPYLDLANSSRAVNSLPPLPLSFRPPPIFAESDLRHSPTSSSSNPYPLQSVLPQRLPQGSTLLPESDEDRYSNMLGSSQSTVIQQSQSGLSGTSNSLVLQELQASAAWYSSMRELETQPTSSSRLGRASLSNGQNLSNGQNLSNGKNVSLYSSPALSDLTTQGGLTALPYQACPSGAFRDGPVDQEQILGDPQSPLPYGVSGSSSSSVIGPKGGSSSMPRLNNSKPVFQNDFTGRRMLQPGPYCPSSSGADLLLQPAIVGNCPVNLPDENCFIQRAPPPKPLRTYTKVYKLGSIGRALDVTRFSNYDELRCELARMFNLEGQLDQRSGWQLVFRDNENDILLVGDDPWDEFVSSVRGIRILSPSEVNFYMNEDRLGAAYNNLGTGTLKQY
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MASPQENDSKPETTITLNDSKPETTITLRSNDGEIFEVPETVAVLSVTIRNMVEDGCAGGIIPLEEVDAETLSWVITYLKKHAALLDPSSKTEKDELDAEFFSDKEFNSLLAIVNAANYLNIEELQDASTGQIAKFIRNKGVATVRKLFGVENDYTPEEEEALRREHQWAHEDGVEPDED
The following text describes a protein:
Function:
Catalyzes the flavin-dependent Baeyer-Villiger oxidation of 1-deoxy-11-oxopentalenic acid to pentalenolactone D in the biosynthesis of pentalenolactone antibiotic.
Sequence:
MREKYRQERDKRSVGRTYQFARGDFSRYARDPYTERQEREPLTDEVDVAVVGAGIGGLLTGAHLRKETGLERIRLIDGAGDVGGTWYWNRFPGVRCDVESYIYMPLLEETGTIPREKYSTGPEIFAHLQQIAHRYDLYRDALFQTTVTELRWDEAAGRWLVSTDRGDLIRARYVAMSIGLMHRPKLPGLPGLETFAGHSFHTSRWDFDYTGGDSTGGLTKLKDKKVGVIGTGSTTIQLAPHLAEWAEQLILFQRTPAAVDVRGNRPTPPEWAAGLAPGWQQRRMENFHALTSGVPQDEDLVQDRWTQTTAKLAAAILPTGDTGGDPKERALAAERADFLKMEELRARIDSVVTDPATAAALKPYYRVYCKRPCFHDGYLQTFNRPNVTLVDTQGQGVERLTPAGVVANGREYPLDCLIFATGYEHEFAVPYTERAGYDIVGRDGLRLSEKWADGARTLHGLQVNGFPNCFILSKVQAGRHVNIAYMLGEQTRHLAHIVKCVEERGHQVVEASEAGEKEWVEEILRLATNDIDFLENCTPGLYNNEGDPSGLPLLNSSYGGGSVEFVNILRRWREAGDLAGLELR
The following text describes a protein:
Function:
Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound.
Subcellular Localization:
Secreted.
Sequence:
MAPPPLSWLLRLAALCHLTALLAGQHLGVKKCNVTCHKMTSEIPVALLVHYQRNQESCGKPAIILKTKQNRIFCADPKERWVQKAIAHLEHQIAVTIRNGGTFEKQIGVGEPRTTPATRGMDRSAVTEPKSTQENSGQEAQRASGTSPELSTGVADSRGTRFPSTSKAPDGGPPAGSQKTEFFSAATLTATTSQQSSAAYKPGSGLWTEGKASEALPTQASSTQASSTQAPSTQTPSTQASSTQAPPTQAPSTQTLPTHAPPTHAPPTPTPTISHTASENRVDPEGRPVWIKGDNPTPENSLGPKEMSSLSAHMDAFRGPDHTPHLSTVLVSSPGVPSREPVASGSWVSKAEEPIHATVDPQRLGILITPVPDSQAATRRQAVGLLAFLGLLFCLGVAMFAYQSLQGCSRKMAGDMVEGLRYVPRSCGSNSYVLVPV
The following text describes a protein:
Function:
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
Sequence:
MWPSVEVPRAEPRPEAGPQGVGSRRSSNISKLPAPAPAVTRELPSFSNSRLNSAIPVPSSPNEVGRRLGTMTRAGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGMARPDSLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMCGHRVPPQSVIHFYSATKYAVTALTEGLRQELLEAQTHIRATCISPGLVETQFAFKLYDKDPREAAATYEHIKCLRPEDVAEAVIYVLSTPPHVQVGDIQMRPTEQVT
The following text describes a protein:
Function:
Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSDTDLDSRLTTPLPEAGNDAGDPNRPISQERDTPEPPMANPDLDMDDLDNAENGAESDNESDLSEVDEANFDDFDASKVALDERPMVGIDEDVAKTLKASKRKRTDGEGKKPKEGKREKKKRPRRDSDEDPDGIEIDGKRVRKPKRVDGDRKERDRTKERRKATPEPENDENLTPDERRRRALDKAMDAALKNPNKRRRKKDEVDLEEAFDDEIAALKLRMEEACQADNAARDANLPATRKLEMLPEVVALLNRNTIQHSIVDPDTNFLQSVKFFLEPLNDGSLPAYNIQRDLFQALARLPIEKEALLSSGIGKVVLYYTKSKRPEIGIKRIAERLLGEWSRPILKRSDDYKKRKVATKEFDHQAAQLAIRPSGSQSSQMPSSQRTQLTARDIERQRLLAPKIISNRARMETSNTSYSIAPRSNFDPSRGLDPASRPIGAGGVDAFRKMTAKQGKKR
The following text describes a protein:
Function:
Transcriptional regulator. Binds and recognize ATTG sites.
Subcellular Localization:
Nucleus.
Sequence:
MDSLNDIIDHQTFSQELVEDASEFITVGHHSERPSQSSQQPNSGQDLTMSMQDIISCPVKHRTCSASGSGSASGSDSVVMVIDALGQGNRQSAYQIVPQQLQQRNMPLPFGLLERDRQHMQHGREVNTSPVDFVSSDINLDGLTVDADVSQTDHSQETAVKQEQKLLIVQSKSQDQSHRRIRMLVDVSSVNSGLGVHVDDMDEISSDGVGCDDEGVTLSHQHLLEQEEQFGLTSHHPHLQPHTQIIHGLHQRSTHSEMGLDNGHGEVLSVIVHSQDSDKEDCEENDDGDAEGDLENEDDDERDSRSREQLLSHSSYQTLTSVNDRLSSPGFSQTSYATLTPIQPLPPISTMSEKFAYSGHISGGDSGDTDVNGDGAGGGVVEVGEVTNQSSEATGTVSISSGNATSSVCSNNDCSSFSALSMPIGSGHLGLGVLSGVQSPFSSYEKLSSMISPPPNNYLVSCDLHSSVSGRVINSSHLQLSHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANREKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARGSLSRHLAPNAPICPADWKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVSGIKQNERSSPGHREQYFLDKSQEPSSVVADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKGTVSSGGAVSNRIANSSDMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLDPHGGPTMIQNPLTNESDSSPASTPVTSVLVGSVVSCRRKEEPQIEQMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKEMQVTIARQLGLEPTTVGNFFMNARRRSMDKWRDDDSKSTMHVAHSRQQQDEQQKDNAHTHSQSQIQDQNHSQNQAIHNSMSQDPYSNLHTTAMSPLGAFDEDADMDLELESHDFDLVDPDEHGDTNDPNGDML
The following text describes a protein:
Function:
Possible role in the function of olfactory neurons.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Nucleus.
Sequence:
PGLVSPTGWLLISRRVFLSTSFFGFRQPTSSPLSPTSLPTLLNYGPRRFRSAIRYVPVMYHPSEYPPVNWRTTVEEASMLGNGGADTGHYDLYSVPGHPFSAPLMDTMSQYELTSIPMTPLQPMTMMSDPRHSEMIGSSLDLEDALGLIPHHPDQDVNPLDPHNLHHSYAPQHHHQLDNHHQPQHSYIPDYASYHQQEMQNELLVPSQRQQPSADMLLPSQMQQPIGSHLTQPLGSQPPPFGTSHPPIGHHLQQQIGSQMQAPIGTKSQAPIGTRTQPPIGPPTAVVQPMQPVPPLQPKTILQQAQKRAERPMPIPPPPLPLSVIEESLMARMKLEDPDMKVREKFKEHVKEGPMIVGGRRYDFVLEMTPAQLTSLASSSGADRSGGPNSSQFQHQFSNHGSSHNHNLLRPSQIAAEKPKPTYRSSSEAPLRKLTVDLIKTYKNINESFYMRKNRREGGAEGAGGPSSAMPPANPVNVPGMSQSGSGSNTNTDASKYESYPPLPANAPISDERCTSRAGIFNNGYDNIGFDYIIKAGEYLGNRYVVVSPIGKGSFGQVIKAYDTVAKEHVAVKIIKNKKTFYDQAQIEIKLLQMMNEMDVEGKYNVVQLKTHFIHRNHLCLVFELLSYNLYDLLRNTNFHGVSLNLTRKFGQQLTKTLLFLSSPQLSIIHCDLKPENVLLCSSKRSTIKIIDFGSSCQIGHRIYQYIQSRFYRSPEILLGIAYDTKIDMWSLGCILVEMHTGEPLFAGGSEYDQMMKIVEVLGIPPAELLDKAPKARKYFEKREDGSYTIFRNKDSTYRPPGARSLAEILGITTGGPRGRRMNEPGHTVEDYSKFKDLIKRMLRYDPKQRIPPHYAIRHPFLRKSKEEEHQRTSGQFASNTNLASSPSLLMNENNLSSTFDQWATKEAIEAIPSGSRHQPYSSTASTSNSQPNYDSILPPYAHKQRGKSIDEGDWRVSQQRTMNPNSDPYPNLGGYQHPSEDPWTMRSQHQPADSGFGHRNAHDNSSGNSLNSYLGSSQPSFSAPHQPKLVLHPRNPPNFGQKMVQGCGNKCIKYFFFLVNFILFALGGIVCGLALWVRFDNDFQNKVFNALNLGTDSNGSAKVLQLDTLYIILYVIAALGLIIFILGFFGCCGSFIESTCVIGIYFVFIAILFIALLAGGIYVFVNKGNIRQEFINVWQQEFVNKYNTLPLAISTNVNNIQSQLKCCGANGCQDFSVPPTSCNCTGNGATFVRKGCAVQIYEYIDSNILIILIIGIAILVVELVAMIFACILCHALKEKSSMNF
The following text describes a protein:
Function:
May function as a negative regulator of TGF-beta signaling and thereby inhibits activin-mediated mesoderm formation.
Subcellular Localization:
Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
MHNLMGLNSTSESIHSNVSCTCNCKRSLFQTMEISELEFVQIIIIVVVMMVMVVVITCLLNHYKLSARSFIHRHSQGRRREENLSSEGNLWPSESTVSGNGIIEQHIYTPRPSDRLSVPSFLQRDRFNRFQPTYPYIQNEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDSSVYGGPCPPSSNSGVSATSYSSNGRMEGPPPTYNEVIGHYPRSSFYHCQQPNLATPSILESNRLQPGNHGLDSTITRSKDKDKQKGQPF
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSHACNIRASINTRCFRVFVLAFAEITLHYSSEAAVMRVVDQKSYRLAASARFDWRSAECTASTIGDVHPDDESSNDTDTDREWLQKIVDDFSITLIPSPARNNGNKNNNIENNEDNKDDNKEDHNKVHVYGKGIGARFRVSLDTLIFDSSVSLENNVDTPNYTEQKHITNSRSDSEDRRARSVYGRTLKFSRNQSVWNLFCIHYTRLSVSPSRETKGPVTRHIFGPLNFCLEHNKFTEHINSIRSKCLQCKSWPDGKREKAIKASLERHQQAQNLAPMKVFIKECLDKLQHALRDNSIKVVVQRLEAITRNVGLKFYDNGNGTDCFISSDMFYVEVKMETNGKVSEVKVAHAGDPESCPELTRVLREGDYEEFACHLKGLSDLYELSGDTFQKSKILMALKAAEVDLNMISALSGPCDTSTDTILQCPVGFATPRQGGRLMRLTYFASPYDLLDRNNPGKNLEFSKDNNSIKGVVQRLEAITRNVGLKFYDNGNGTDCFISSDMFYVEVKMETNGKVSEVKVAHAGDPELNKPMPVAVESVQKIYSAIHETGIRYTVPSMRQWLQSKGIEEGDNIDTFYAVIPNHYHTYYLNNCDPQEVTNVSRNGVLIHRVPFTHPRHVPVIIKVHTHTLVMSMSLPRYIHTPSSCACRYQGNFVHSSKVPIHSLVIREQLRRQATYNTLLTSALRTHKPPPTIEGKSEHTFELSTSGTFTVTITFAHPCSVGMASIDFAVGEDSSILASLHTVPGQPVFCSNDYISRVMQRCLSIPATMRCLIRKAESFKPEELPVKTTEPAVLTPALTSATQPSVKLDRLSIPGNPFFTPSGPTTPGFFTASPTFASLALETPSPTLGAFPFSISPTMSSFTFTGSEMGAMNLESGSIKQPEKKLDTPKPPSTPKLTLTLKRKRADEYVVKDFQMPDDVPKPEKKSPEHPTTQPSSVGVVSESQMDVDGPGMIDEGMMEGMASNFDSSFMLGPGFADVSGSDSRTTMNIVSSMASIASTSGLGRGGDSGGDLFELSTGGTDGGDLEGILQSLPGASHLPPGIVSVGGGLDFDAGLGPGVHNIDVDPNFDIDAAIDADTSNDPSIAGVVASAGAFDVDSALDFDLDHITGTPGDLSVTSAGDHGTGLPEGLLSPEDAMGMDTGLGAHGD
The following text describes a protein:
Function:
Catalyzes the formation of an amide bond between 3-dimethylallyl-4-hydroxybenzoate (ring A of novobiocin) and 3-amino-4,7-dihydroxycoumarin (ring B of novobiocin) in an ATP-dependent reaction in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
Sequence:
MANKDHAPEHYVTRILAEATLDGARPVVRWRDTVITGTQLDRSVRRVVTALREAGVARDHAVAVLTQVNSPWMLIVRYAAHLVGASVVYITGANHGIVTHELPVATRVRMLREAGASVLVFDESNAQLAETVDETVRDKLVLCGLGHPASGTVSVDGRPVDDVSVDFTPEAPELAMVLYTSGTTGQPKGVCRSFGSWNAAALRGAAYPRPVFLTMTAVSQTVAMIVDTVLAAGGSVLLRERFDPADFLRDVGEHRVTETFMGVAQLYAILGHPDARTADLSSLRHVLYLGCPASPERLREAAALLPGVLAQSYGSTEAGRITVLRAADHERPELLATVGRAVPGVTIAIRDPETGHDLPVGEIGEVVVHGPEVMAGYVADPEHTARVIRDGWVHTGDFGSVDERGYVRLFGRMREVVKVQDTRVSPTEVEKVLVGCPGVVDACVYGHRGPDLIEELHAAVVLGTEGAPSFDTLRDHVARAMTPTHAPIRFVRWRRFPINNTGKVNRLRVREVSAEARGDSPDVLVDR
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MALFGSSPLVDAFPSPRFSEPPSPTKTETDLPIDVDQSFNSSLSLSDSPYFSPTPSMAVGAKSAGSSSMLSAAPPSFSLKCKQPEAAPTQVKPPLQSKSTTETTLGSGQLSRGRSFGMDITNNVLHQPDSNIRNNKGKMLPPAVPEARMLKANASVPMQWTSSNEELGECSKNSSLFGVPRTESDPAISGSPLSSLSRDDSAMQVDSPQIRSNSRPGSLMASPALGGPASCSSSPDLGSFFCDSPAPSSQAPPAKRRSLVSGPPASPSSGSPSAKRTSLGLGVSRPPLDKTASSSALLFGGGRANTVASRRGPSYKRPTLGPLAAPSCDASRTASTNSAFPILYGPPKQTLGQSGTFPRAANAPMRRAYSVCDQNTANEMDDDDSEFENSPCVGAHAEYARRYGARMGPRIDGSPGFKSVRASIAASGEGVVSPLHKGKKTSPYGPGGLPGFGDNEIDGKILPCHKVKEDGLVRITPDTLDELLSGKYSHKIKRYHVLDCRFDYEYDGGHIAGAINVKSMDALDKLLLSEADGIHADGECLPRPSRSGQLEDGQPVVLIFHCEFSAKRAPTFAKHLRSRDRLLNNAIYPKIYYPEVYILEGGYCGFYQTRPERCDPKGYTPMDDPKHFERRDSDLHDFRKFSRTRSFTYGEQQQPSSRALLPCPPLAFAAASAAAARRIGAQGGSTSGNNTIKEEDDQDNSSSPHPGDSSAEMDTDASPCPRAVLSLGQPPIFGSAKTRVLGRVGFSRVASYAGTTTIPAPRP
The following text describes a protein:
Function:
Receptor for EDA isoform TAA, but not for EDA isoform TA-2 (By similarity). May mediate the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAHVGDCKWMSWLPVLVVSLMCSAKAEDSNCGENEYHNQTTGLCQQCPPCRPGEEPYMSCGYGTKDDDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGVSAHSSSTSGGSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYIMKTKPSAPACCSSPPGKSAEAPANTHEEKKEAPDSVVTFPENGEFQKLTATPTKTPKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSVTSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASPPPAAS
The following text describes a protein:
Function:
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Sequence:
MEPDGSPRRIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDPSSPEIDEDRVANPLLKVSGWRLCPPLSSFSLLLIFNV
The following text describes a protein:
Function:
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
Sequence:
MPLNMLDATVSSFNQVFERFKSEAPKHQANLILFLADKDPSTSLSWCPDCVRAEPVIYKKLEASSANVALLRGFVGDRPTWRNPNHPWRVDSRFKLKGVPTLVSWENGAITGRLEDHEAHVEHKINSSLYYHSFLRVLLC
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Sequence:
MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGSASSSSQESLRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRRSAASRLHQCL
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Sequence:
MKKDEQAKIARRKNILYIYIAMTTTMISSFNSKALNCVLWNTPKFSSPPPNLFSSTKRRRLQQIRKKKAHDQATVSSLISSTAVYQTTTLPVELTALVTVRKSLKLSIQDMMLHWFGNHDHFSHHKEKEKCLVLQLVSTETEAESTKPKLSNEAILDWSKDLNLNLILGAGKTSYEVQFEVDPKFGMPGAITVSNKYEKELYLDSINVEGVVHIGCNSWIQPDKDSSEKRIFFSTKAYLPDETPAGLKELREMELRQLRGDGTGLRLPSDRTYDYDTYNDIGNPDAGIEYIRSTLGGNTHPHPRRCRTGRPPTSTDDNMESPENEFKRIYVPRDEEFEEAKQGALDVGKLKGILRHIIPTLTIIASRDSNVFKGYVDTNCLYSTDMSLPKILNKVQEFLKFDPPKLISDEEFGRQAIAGVNPMSIQKLTVFPPVSKLDPSIYSPQESALKEEHIIGHLNGMSIQQALEENKLFILDYHDIFLPYLDQINALDDRRAYGTRTILFLTPLGTLKPISIELSFPPTNSDSPSKQVLTPPVDFTTNWLWQIGKAHVSSNDACAHQLIHHWLRTHACMEPLIIAAHRQLSVMHPIYKLLNPHMRYTLKINALARQFLINAGGVIESNFTAGKYCMEMSCAAYRDWWRFDLEGLPADLLRRGMAVPDSTQVHGIRLVIEDYPYATDGLLIWSAIETLVRTYVNYYYPDASAVNFDTELQAWYNESINLGHADLRHASWWPKLSTPDDLTSILTTIIWVTSAQHAALNNGQYPYGGYVPTRSPHMRRLLPEEHDPEYTTFMQDPQKYFLSSFPSLLEATKYMAAIDIISAHSPDEEYIGDRKDLSTWSADTVIIEAFYRFSMEMRRIEKEIERRNTDSNLRNRCGAGVSPYELLMPSSEPGVTCRGVPNSISI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDTNNTNNINSLENPIDLENDPNILFTELNVKLESLITFLTKNDKDNQIFVDEIIDNKVTDLLIASKELENYFISQQSKYSAEKNKIQLKQEIYKVKKEIENKDRLIERYKNKVKEWKYHFEPLYQSQNHILHSTAQGLSGIENQFSPVFTPMPNTPSILQNLSQAKPSPSLGLGSTIL
The following text describes a protein:
Function:
Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Its major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition (By similarity). Possible involvement in cell proliferation and adipose tissue development (Probable). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity).
Subcellular Localization:
Secreted.
Domain:
The nuclease-like domain is most probably catalytically inactive as residues that are essential for catalysis in the DNA/RNA non-specific endonucleases are not conserved. However, it is required for the stability of the protein and the catalytic activity born by the Phosphodiesterase domain.
Sequence:
MARQGCFGSYQVISLFTFAIGVNLCLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSKKDIRFMKIPYTIGSYLAVTPDYNFEKKVIKRPRVHQIYAFLLACAISVLSGITVVDNATLSMKQQVPTVFILDLINFFFLFLHPIVMITNSSLLSVSFWAKINKNFQFIDEHFNNVHKKEPNFFKNCYVQFALCLGGYLLDNLVVTISSLNLFPELALTKIHILSQIFYTYEFFTCFLICNLTTAFKCRFDEISRELQNHMKPSTTFIRQNGHFWRILSESAVCFNQIFGWPLIFLIGRGVAQLLQSLHLTMLALNSDLTLKKGIYGDLVVANLFIVAYLTVCLVFVILTCDSAASSGNEISNLCYKLQKDFADSSSERRELILLAKEISDNPIKFTASDFFEINKSTFFGIISVTTTYLIILIQFKNS