lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAAAALRDPAQGCVTFEDVTIYFSQEEWVLLDEAQRLLYCDVMLENFALIASLGLISFRSHIVSQLEMGKEPWVPDSVDMTSAMARGAYGRPGSDFCHGTEGKDLPSEHNVSVEGVAQDRSPEATLCPQKTCPCDICGLRLKDILHLAEHQTTHPRQKPFVCEAYVKGSEFSANLPRKQVQQNVHNPIRTEEGQASPVKTCRDHTSDQLSTCREGGKDFVATAGFLQCEVTPSDGEPHEATEGVVDFHIALRHNKCCESGDAFNNKSTLVQHQRIHSRERPYECSKCGIFFTYAADLTQHQKVHNRGKPYECCECGKFFSQHSSLVKHRRVHTGESPHVCGDCGKFFSRSSNLIQHKRVHTGEKPYECSDCGKFFSQRSNLIHHKRVHTGRSAHECSECGKSFNCNSSLIKHWRVHTGERPYKCNECGKFFSHIASLIQHQIVHTGERPHGCGECGKAFSRSSDLMKHQRVHTGERPYECNECGKLFSQSSSLNSHRRLHTGERPYQCSECGKFFNQSSSLNNHRRLHTGERPYECSECGKTFRQRSNLRQHLKVHKPDRPYECSECGKAFNQRPTLIRHQKIHIRERSMENVLLPCSQHTPEISSENRPYQGAVNYKLKLVHPSTHPGEVP
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Together with its coactivator RsoA, positively regulates the expression of at least three operons, including oxdC-yvrL, sigO-rsoA and yvrJ. Required for the acid stress-dependent induction of the oxalate decarboxylase oxdC.
Sequence:
MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKEIRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQDDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKGLENIRKQLAAQKKGEK
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MKIGYFGTPEHSAKLLEALIDSQLTEVLFVVTNPDRPKGRSKIPEPGPVKKKALEYNIPVFQYESIKKEKEKALSDFGLFSADLYVVFAYGSILPKEVYAHSTLTSINLHGSLLPDLRGASPVQTALWKGYTKTGITIQYIGEKMDEGDILLTKEVEIAPEDNTGTLMDKITDAGIESILQLLKTYDGKPFPSVPQAHDKATYCGKIKSEDRILDWSLKSEELHNRIRALYPDMIATTTFRDKRMNILKTKPSSLSLEINPTPGKLKRLDKKRLLTQCGDGRFLEILELQPENKNRMTASDFLNGFRIQEGETFG
The following text describes a protein:
Function:
Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone via a phosphoryl group transfer from DhaL-ATP.
Sequence:
MRRLVNDGYEAVEEMLAGYVAAQGKYVDFAENDKRVIVSKQMSEEPRVRIIVGGGSGHEPLFLGYVGKDFADAAVVGNINTSPSPEPCYNAVKAVDSGKGCLYMYGNYAGDVMNFDMGAEMAADDGIRVETVLVTDDIYSAEKVEDRRGVAGDLIVFKAAASAAAKGLDLDAVKQAAEKANANTFSMGVALSSSTLPVTGKAIFEMKEGEMEVGMGIHGEPGIKRTSIEPADKVVDQIMGYLIEEMKLTSDEEVHVLINGLGGLPVMDQYICYRRVDEILKEKGVHIHNPLVGNYATSMDMIGMSITLVRLDDELKDLLDTPCDTPYFKVD
The following text describes a protein:
Function:
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Subcellular Localization:
Cytoplasm.
Sequence:
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVRADGEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDESIPEDALNLDDLTADTLANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYTPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEDFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKIKNNPHLSTEDKLKALSSLSPKKVEFVHMLNATMCATTRTICAILENYQTEKGIVVPEKLKEFMPPGLQELIPFVKPAPIDQEPSKKQKKQHEGSKKKGASRDVPLESQLQNMEVTDS
The following text describes a protein:
Function:
Has an essential role in the assembly and organization of the sperm flagellar axoneme. Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (By similarity).
Subcellular Localization:
Cell projection, cilium. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the entire flagellum and predominantly concentrated in the midpiece. Co-localizes with ODFP2 at the centrosome (By similarity).
Sequence:
MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKDTAPMDNTFLMVKPNGPGFTGGGFPLRSTKMTF
The following text describes a protein:
Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MISQVPDYVYQHKVVDYDKNMPLVFIGGMPRSGTTLMRAMLDAHPDVRCGQETRIIPRILGMRANWLKSPKERVRLDEAGVTNEVINEAITQFILEVIVKHGKPARFLCNKDPFTLKSIKYLKELFPNAKFILMLRDGRATAHSIISRKVTISGFDINSYSTRDVLTKWNRAIETMFVQCNEVGSKNCLPVHYEQLVLHPAAETRNILKFLSVPWNEAVLNHEKHMTNISLSNVEKSTDQVQRPLYLDALTSWFGKLPDDVMRDMATIAPMLRRLGYDPNDPTPEYGIPDPFVLNKSRTAR
The following text describes a protein:
Function:
Aldo-keto reductase that significantly contributes to cellular methylglyoxal detoxification by catalyzing the NADPH-dependent conversion of methylglyoxal to acetol.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIPVFGLGTFRLQDQIVIDSVSQALTLGYRAIDTAQIYENEAPVGQAIQESGINRDELFITTKIWIANLSKDKLIPSLRESIQKLKTDYVDLTLIHWPSPNDEVSVAEFMSELLKAKGLGLTRQIGISNFTIDLMKQAIAAVGAEEIATNQIELSPLLQNRNVVDFAKQNGIAVTSYMTLAYGKALAEPVIKTIAEQHGATPAQVILSWAMQLGYGVIPSSTKAANLASNLLAQKLCLNAADMALIATLDRNERLVSPDGLAPKWD
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MGKALGPTDEFFRRRDEWRKHPMLTNQFRHATPGLGIAVVAFGIYVAGEIAYNKVYAPSHTSPRSH
The following text describes a protein:
Function:
Involved in the synthesis of the major structural component of photosynthetic membranes. Required for proper thylakoid membrane biogenesis. Does not discriminate between prokaryotic (18:1/16:0) or eukaryotic (18:2/18:2) 1,2-diacylglycerol species, but operates with some preference for the prokaryotic one. Is responsible for most galactolipid synthesis in chloroplasts. Required for the formation of thylakoid membranes and functional photosynthetic electron transport during cotyledons greening in young seedlings. May link galactolipid synthesis with the coordinated transcriptional regulation of chloroplasts and other organelles during cotyledon greening.
Subcellular Localization:
Plastid, chloroplast inner membrane.
Sequence:
MQNPSTVTQESAAPVFDFFPRLRGLTSRNRSPCSNSDGYALSSSNALYFNGFRTLPSRRMGKTLASLSFNTKSSAGSSLRRFISDFNSFIRFHCDKVVPESFASVGGVGLSSDENGIRENGTGGVLGEEGLPLNGVEADRPKKVLILMSDTGGGHRASAEAIRAAFNQEFGDEYQVFITDLWTDHTPWPFNQLPRSYNFLVKHGTLWKMTYYGTSPRIVHQSNFAATSTFIAREIAQGLMKYQPDIIISVHPLMQHVPLRVLRSKGLLKKIVFTTVITDLSTCHPTWFHKLVTRCYCPSTEVAKRAQKAGLETSQIKVYGLPVRPSFVKPVRPKVELRRELGMDENLPAVLLMGGGEGMGPIEATARALADALYDKNLGEAVGQVLIICGRNKKLQSKLSSLDWKIPVQVKGFITKMEECMGACDCIITKAGPGTIAEAMIRGLPIILNGYIAGQEAGNVPYVVENGCGKFSKSPKEISKIVADWFGPASKELEIMSQNALRLAKPEAVFKIVHDMHELVRKKNSLPQLSCTA
The following text describes a protein:
Function:
Involved in the recombinational repair of double-strand breaks (DSB) in DNA during mitosis and meiosis. Has DNA dependent ATPase activity. Promotes D-loop (displacement loop) formation with RAD51 recombinase. Modifies the topology of double-stranded DNA during the D-loop reaction to facilitate the invasion of the homologous duplex molecule by the initiating single-stranded DNA substrate. Required for adaptation from G2/M checkpoint arrest induced by a double strand break, by participating in monitoring the extent of single-stranded DNA produced by resection of DNA ends. This role is distinct from its roles in recombination. Promotes colocalization of RAD51 and DMC1 during meiotic recombination. Involved in crossover interference.
Subcellular Localization:
Nucleus.
Sequence:
MFTLFFFTTDQMNVRPNAPFRPPRPIKGGVAVVQKVVKRKLPTTTNPKPAKILTTDPGSTKYVIQWRKKTSKKNKTWDGDGYAVIKQLENGACEISIKNSDGKPMGKRVFTATPNLDDVISVGPYELELDEKVGSNSTSQTVTRVTHQFKKVAPPTASSRKPLYDDCADAIALPPPPKAKDYVKVNIDPHLAKVLRPHQVEGVKFMYECLMGYRGFGGHGCLLADEMGLGKTLMTITTIWTLLKQNPFMEKGAVVNKVLVVCPVTLISNWRQEFRKWLGANKLNVLTLNNPMSNEKQDILNFGKLNVYQVLVVNYEKLVAHFDELSAVKFDLLVCDEGHRLKNSANKVLNNLIKLNIPKKIVLTGTPIQNELVEFHTLISFLNPGVLPELKLFQRNFITPISRARDINCFDPEVKKRGEEISQQLIELTQSFILRRTQAILANYLTQKTDILLFVPPTSLQLKLFDYITNLKKFNQFEAFTMINLFKKICNSPSLLADDELFKKIVEEKFNLGMASGKINILVPLLLEIASLGEKIVLISNYTKTLDLLEQVLRKVSLTFSRLDGSTPNNVRSKLVNQFNTNPDINVFLLSSKSGGMGINLVGASRLILFDNDWNPATDLQSMSRIHRDGQLKPCFIYRLFTTGCIDEKIFQRQLVKNKLSSKFLDNDATSKSDVFDNDDLKNIFEIDTSTISNTHDLLECVCEGDGSMLSQPTIEESEPPPKQAWVTALELKKKIDDGEALKRTAVKFALNDYRHYNPEVNRNLDFDSALHRIANNSSYENKQLPITFIMSRVTN
The following text describes a protein:
Function:
RNA-binding protein that binds to the 5'-NACUAAY-N(1,20)-UAAY-3' consensus sequence in pre-mRNA introns to promote alternative splicing. Required for mutually exclusive alternative splicing where it modulates the switch between mutually exclusive exons during pre-mRNA maturation. Involved in muscle-specific gene expression regulating the alternative splicing of genes such as let-2 and unc-60 to ensure that their respective isoforms are expressed in muscle. Promotes the removal of intron 10 from let-2 pre-mRNA to allow for the exclusive expression of the muscle-specific let-2 isoform (as opposed to the non-muscle-specific isoform expressed in embryos) in body wall muscles during late larval and adult stages of development. Binds cooperatively with RNA-binding protein sup-12 to intron 1A of the unc-60 pre-mRNA to promote alternative splicing and expression of the muscle specific isoform of unc-60.
Subcellular Localization:
Nucleus.
Domain:
The KH domain and the Qua2 region are involved in RNA binding.
Sequence:
MDCDNGVVSEISDDKELLNLETVIPPPPNDSGHEFIGPSSGPPQVTITPSGVQSGSANGVSTSQQQQYSAEYLSQLLKDKKQLAAFPNVFHHLERLADEEINKVRVVLFQCEFSKESAPLPDAEGDSTVHTEKVFVPAKEHPDYNFVGRILGPRGMTAKQLEQETGCKIMVRGRGSMRDKKKEELNRGKPNWEHLSEELHVLIQCEDTENRAKVKLMRAVEEVRKLLVPAPEGEDDLKRKQLMELAIINGTYRSGTDQSALAAAQLAAVKHQQQPFAAALQAAALQRGVLPMMANGLSRSPTMAVCGAPIVMSPSGRASSAGATATSQAALIMQQQSQLHAANAGNAALQQQAALLQQQQAAEYQQLLLSQAGLYDFSAMQQQYAAVGQNAAVAAAQAQAQAQYGALAAAAAANSAGNQQYADYAGVDLTSQQSAHGGYYVRRWA
The following text describes a protein:
Function:
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with acetylated chromatin.
Domain:
The 2 bromo domains mediate specific binding to acetylated histones. The exact combination of modified histone tails required to recruit brd4 to target genes is still unclear. The first bromo domain has high affinity for acetylated histone H4 tail, whereas the second bromo domain recognizes multiply acetylated marks in histone H3 (By similarity).
Sequence:
MSSETGLGTRLRATSGMGDGIEGAQMLGQHQPALPQPQATVMNNPDPPEITRPNQPKRQTNQLQYLLKAVLKTLWKHQFAWPFQLPVDVVKLNLPDYHKIIKTPMDMGTIKKRLENHYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKISEMPQEETELTVVQSKGRGRGRKEQDASITPMRTRVLSGSLEDKSTVKPPVTPVSKPSTPTPPTVTRAPTPPQTRPQQGRPPAIAQAPIRFSPTISQDVVVPTTVAPTLVPPPLSNHPAVIHTAAQPAKTKKGVKRKADTTTPTTHDPLHESSPLPSDPKPPRAVPRKENGRQIRPTKKTEVPDSQLPAPPVLHPQPAPNAERDTKTSEQLRYCASIIREMFSKKHQAYAWPFYKPVDVEALGLHDYCEIIKHPMDLGTIKVKMENRDYKEAQEFASDVRLMFSNCYKYNPPDHEVVIMARKLQDVFEMRFAKMPDEPEEAPAPVPSLAPGPPAPSIKGPPPTSSDSSSDSTSDSESSSDSEEERAQRLAELQEQLKAVHEQLAALSQPQPNKPKKKEREKRKEKHKRKEEVEEPRKGRIREPPAKKPKKSVQGSGGTPSIKKEAPPPAPRPARPAPPSAPCESSEEETQRCRPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKSQDKIEAPTSGTVKVKGYSSSESESSSESSTSDSEESDSETAPNQKKKGHSGRESRKHHHPMQQPLAAQLPVMKPPSPTIAPSYPLPSSLDSSHISLHHPLHPANVFDAVMQLPPDLPPHLTGQTEHCSPPHLNQHALTSPPALHNAMPQQPSRPSNRAAALPTKPAMPPSASPPPPAPQPPQQPHVHHHHHHHAQPPHVLLEDDEPPSPLTGLPPYLQPLQKSQQPPTQSPIHSLLTSVKVQSQTPMAAPPQSMRHLQPLVYPPPPSTATTAPPPASSHIHQLQSSPVVPQQLPAGQAPPPPQQQQQHPALQGTLVSSHQQHVQHQHAKQQQVIQHHHHHPSPRQQKQETYPGGHLRDAPSPLLLHSPPVPPYPGLTHPPSPQSVQPKKQEIRGASVLQPQPVVMKEDKRHSPSIRPEGFSPGMRPEPQKVPEVLKGPSHIQPRPDLKKMDGGRPIRLPDQSLPPQGMPEKEKQKQEPKTPVAPKKDIKIKNMGSWAGLMQKPPVTPTSAGKSTSDSFELFRRQAREKEERERALKLQAEQAERVRREQDRMSRTREDDEVQDQARKAHEEARRRQEQQQQQQHVQSNLPTAPSPAQSSQPMMDQREMARKREQERRRRQAMAPSIDMNFQSELMEIFEQNLFS
The following text describes a protein:
Function:
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase (By similarity).
Sequence:
MVMAVEDSVVRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLKWSGSHNGPKKKGKDLTFVFDRVFGEMATQEDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGREGEPGIMYLTTMELYRRLEARQEEKQFEVLISYLEVYNEQIHDLLEPKGPLTIREDPDKGVVVPGLSFHQPASAEQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQALRVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKSHVPYRDSKLTRLLKDSIGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLTLKSNVISVDHHISQYATICQQLQAEVAFLREKLQMYEAGAQALQQQCSPQPPTLSIPQSLSSSSLQPGPSSQSSTLECHAKNETLQEESLGSDAQGQEIVEESASEQEQCPQDKQCPTQKPEPNLPGSPSPSVQAKPGTGQHSPQKQDADHSKQLALQVLRLAQRQYSLLQAANLLTPDMISEFETLQQLVLEESVDHRAESPRSPALARGDPLAQALCSESKSSGYCGPVTRTMAKQLNGLTHTLGAPLAPDCTSDKTFQKPTKEKKRKLTPEEPGSLPAPNLEMKRQRQSFLPCLRRGSLPKAQPCSEPRTPKRERASSPSPSSRVCPATVIKSRVPLGPSALQNCSTPLALPTRDLNTTFNVSEESPSKPSFQEFVDWEKVSPELNSTDQPFLPSAPVFIFTKGRKPSLPAVTASKKRRTMRPSVSRGRSCIARLHSSTLKKPNRPFTVPEPPLSPHCLDDQRTPKGLTGVTESY
The following text describes a protein:
Function:
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability.
Miscellaneous:
MISCELLANEOUS: In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, KbaYZ in K-12 strains is not involved in the degradation of these compounds.
Sequence:
MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA
The following text describes a protein:
Function:
Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'-phosphomononucleotides. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA.
Miscellaneous:
MISCELLANEOUS: Encoded in the Rac prophage.
Sequence:
MSTKPLFLLRKAKKSSGEPDVVLWASNDFESTCATLDYLIVKSGKKLSSYFKAVATNFPVVNDLPAEGEIDFTWSERYQLSKDSMTWELKPGAAPDNAHYQGNTNVNGEDMTEIEENMLLPISGQELPIRWLAQHGSEKPVTHVSRDGLQALHIARAEELPAVTALAVSHKTSLLDPLEIRELHKLVRDTDKVFPNPGNSNLGLITAFFEAYLNADYTDRGLLTKEWMKGNRVSHITRTASGANAGGGNLTDRGEGFVHDLTSLARDVATGVLARSMDLDIYNLHPAHAKRIEEIIAENKPPFSVFRDKFITMPGGLDYSRAIVVASVKEAPIGIEVIPAHVTEYLNKVLTETDHANPDPEIVDIACGRSSAPMPQRVTEEGKQDDEEKPQPSGTTAVEQGEAETMEPDATEHHQDTQPLDAQSQVNSVDAKYQELRAELHEARKNIPSKNPVDDDKLLAASRGEFVDGISDPNDPKWVKGIQTRDCVYQNQPETEKTSPDMNQPEPVVQQEPEIACNACGQTGGDNCPDCGAVMGDATYQETFDEESQVEAKENDPEEMEGAEHPHNENAGSDPHRDCSDETGEVADPVIVEDIEPGIYYGISNENYHAGPGISKSQLDDIADTPALYLWRKNAPVDTTKTKTLDLGTAFHCRVLEPEEFSNRFIVAPEFNRRTNAGKEEEKAFLMECASTGKTVITAEEGRKIELMYQSVMALPLGQWLVESAGHAESSIYWEDPETGILCRCRPDKIIPEFHWIMDVKTTADIQRFKTAYYDYRYHVQDAFYSDGYEAQFGVQPTFVFLVASTTIECGRYPVEIFMMGEEAKLAGQQEYHRNLRTLSDCLNTDEWPAIKTLSLPRWAKEYAND
The following text describes a protein:
Function:
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MDLVGVSSPEPGPAAAWGPSKCPWATPQNTVSCSLAEVMSEELAKELQLEEEAAAFPEAVVAEGPFISGENMDTSSDLMLAQMLQMEFDREYDAQLRREEKKFNGDSKVSISFENYRKVHPFEDSDSSEDEVDWQDTRDDPYRPAKPVPTPKKGFIGKGKDITTKHDEVVCGRKNTARMENFAPGFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSLEDEKEDGKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLTRMQKAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLSEEEMKDAYHQTLHLMQQLYKECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALNERELFNAVSGLSISADNEADFLAEIEALEKMNEDHVQKNGRKAASFLKDEGSPPMLYAE
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MYHHTSWSFLFGLETTLNHVKHVGLLGDGFEFILGGDKDASSGRSLSHLANYKFYSSMGDMVQVDTWVAASRKKGMQCDWMICDYKTGEILTRASSNWVMTNKVTRRLSKIPDEVRAEIVKFFVDTPPIVDDDNIKLPKFDDNTTDHVRNGLTISKVSFFFSFYNLGDVINYFVDFSLEIFDDTCVNAMIEVLFIPPIFFNNLIPNI
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSDPLPPDAVGRRIDVSGELATVRYVGSVPPTAGVWLGVEWDNPQRGKHDGGHEGTVYFKCRNPTGGSFIRPNKANFGVDFLTAIKNRYVLEDEEEDVRREQALVIGNRPVETVGFESIKKRQSQLNRLQEVSVCGYAVNCAGPEGEITKMCPNIRKIDLSKNLLSSWDEVTRIADQLTDLEVLNLSENKLKFPPVDAPPSPGTFSALKVLVLNRTGITWTEVVRCASGWPVLEELYLAANDLAIASRPPDALQTLRLLDLSGNPLVDENHLRFLASLPRLEQLILSNTGLSSIHFPDAGIGSRTAMFPSLQYLVVSGNQITQWSFIDELDKLRSLRSLTCTRTPLTEGSEEPQTVRQLIIAKIGRLKTLNRCEISPEERQGAELDYRKKFGNEWKAAGGHQKPELDEPGAEFLAAHPRYRLLCLKYGAPEDGELKAQQPFMLKNQLLTLTIKCPDRPAQKLIQRQLPDSMTVQKVKGLLSRLFRVPGSELRLSYESPKMEGREIRLESDQQPLQFYSVENGDCLLARW
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Sequence:
MDPCECSKTGSCNCSGSCNCSNCACTSCKKSCCPCCPSDCSKCASGCVCKGKTCDTSCCQ
The following text describes a protein:
Function:
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFALGGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYNPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPDLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQERFSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALRIHTDIDSQGIFFTDLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLNALALALPVARTQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPMEIATFRLRLG
The following text describes a protein:
Function:
Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD.
Sequence:
MAAQLKKVRKLFIDGCNAAIINNLLDDLLDKSVLTDSEVEYINECNAITKDRCRRMIDNIKNKGDYSSNILLQCLVENHKTLAKNMGLDVSESAIAPQPILEQNKKTNENTVSEPAIAPQPIQEQNKKTNENTEISSVIHCSDKDFKEIHDTQGDKIYEMRKREGRKRLALIICNEKFETLTERQGAKVDLDGMTKLLNELGYQVLQETNLAKEEMLKVLKEFAAREEHVDSDSTFIVLMSHGDKPGVCGTDSKKIEHEKGQCQVTNLLQTDEIFSIFNNIHCPKLRDKPKVIIIQACRGEERGQKLVCDAVALPPEEQLEDDALHRVQRETDFICFCSSTPDTVSWRHPTMGSLFITGLIKKMNELAHCQPLMDIFLEVQSSFKGQRQMPTQERSTLTKKFYLFPGH
The following text describes a protein:
Function:
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. Acts by acting as a reader of m6A methylation. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions.
Subcellular Localization:
Nucleus.
Sequence:
MPRAARKQTLPMREMADLDAVHLGLDENEADIAEELQDFEFNTRSEASESNGGDSSDSEPSISSVSTATSSLAGSSKRKTKKPAKQSPQPAVETKSSKSSAKNKAKREPTPEELNGGKKKKRTDSGTKKTTSSEASDKVKSKSPDTEDRQPSAKKSRTKIPSNANDSAGHKSDLSEAEDEKPSLPTLESDSESSDSDSGTQHKRNGGNGGGNGRGKPSSKSSTPEKDSVGGGTHSHSQKGYDYMTKLNYLFRDTRFFLIKSNNSDNVQLSKNKSVWATLPQNDANLNQAFKEARNVLLIFSVNESGKFAGFARMAAPSRRDIPQVAWVLPPSISPKALGGVIELDWICRKELSFNATLHLHNTWNEGKPVKIGRDGQEIEPKIGGELCRLFPEDEQIELTPILKKSKETARVMREKGIHVIYKPPRSLSSRGHGGGGRGGGRGSNHDHLGPMRHKRSYHGAPHHRPYRHHHGMGLPPGGGFKRSGSPYRQMGGAAGAPPGGPGDMAMPSWERYMSSAAAAEAYVADYMRNMHGQLPPLPFVPPFAQLPIPGAGAGAAGALPPGAAAAMYEQLPPPVRYYDGPGAPPLPDYPPPQRPPPPGFDKAPSYEEFAAWKNAGLPTVPPPGFPVYGGAANGGSNGAGGLAAAQAAAAGGGMGAGGGSGGGMGGPGGYRNRDGNNGSAGGRRREYGNRSGGGGSSRDSRPFRERGGGGGQRSYRDNRR