lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with GPA1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate(IP(3)) as a second messenger. Promotes PI-PLC activity and IP(3) accumulation. Involved in the blue light (BL) signaling. Together with GPA1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. Probably involved in cytokinin signal transduction. Plays a positive role in gibberellin- (GA) and brassinosteroid- (BR) regulated seed germination, probably independently of a heterotrimeric G-protein. Mediates seed dormancy abolition, and promotes seed germination and flowering.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localized to the outer edge of the leaf epidermal cells in a punctuate pattern.
Sequence:
MSAVLTAGGGLTAGDRSIITAINTGASSLSFVGSAFIVLCYCLFKELRKFSFKLVFYLALSDMLCSFFLIVGDPSKGFICYAQGYTTHFFCVASFLWTTTIAFTLHRTVVKHKTDVEDLEAMFHLYVWGTSLVVTVIRSFGNNHSHLGPWCWTQTGLKGKAVHFLTFYAPLWGAILYNGFTYFQVIRMLRNARRMAVGMSDRVDQFDNRAELKVLNRWGYYPLILIGSWAFGTINRIHDFIEPGHKIFWLSVLDVGTAALMGLFNSIAYGFNSSVRRAIHERLELFLPERLYRWLPSNFRPKNHLILHQQQQQRSEMVSLKTEDQQ
The following text describes a protein:
Function:
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MFRAQQNAFDDAVAKATDENLTSENWEYILDVCDKVGAEESGAKDAVAALIKRLAHRNANVQLYTLELANALAQNCGPKIHRELASRSFTDALLRLAGDRNTHQQVKSKILERMEDWTEMFASNPDFGIMEQAFMKLRTQNPNLQPPSKPGKREITDLDRQKEEEELQMALALSIREKSGSAPQPQVESSSSVSAPENQAQAAPAGPVPSGTSAATVSRVRALYDFQPSEPGELQFRKGDVIAVLESVYKDWWKGSLRGQTGIFPLNYVEKLPDPTVEELQREAQMEAEVFGQIKNVEKLLTLLSTRSSELNVQENEEITNLYNSTLSIRPKLVELIGKYSQKKDEFTQLNEKFIKARRDYESLLEASMAQPPQQQFGRPGQPQYGYPGSGAPAGYPRGPAQQHDPQRYFSPRPPDNQPNASYYPPATQSPGPGHTSPPGPYQQQPQQPAPDSYQPVHHRPESTYDQPQELGTSVYDSPVERLQYPPGPSGGQPHYQPPPQQTPQPDFSASSPNLVNQSQSPYPATPVTQPPPPTQQPPPVPGTASGSAPYPSASPSAANYQAYRPPQGGIPNHNPAAFYQ
The following text describes a protein:
Function:
Type 1 keratin (Probable). Maintains postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially via regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity).
Miscellaneous:
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sequence:
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP
The following text describes a protein:
Function:
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKMSEIIATLKKDYIYNLMIKGKRQDGRGFKDFRDLKLETNVIVKAEGSAKVTLGNTQVLVGVKLQTGTPFPDSQDEGVIITNLELNPIASPEFEPGPPREEAIEMARVVDRGIRESGAIDIKKLCITVGESVWIVFIDVHVLNDDGNIIDASCLAAIAALMTTMVPNEQQGLGEDVPLAMKEMPVGITIAKIGSKLMVDPSLDEEAVCETKLTIVSSSDGSVAGMQKMGISPLTEAELFEAIDLALEKAAELRGLYLEGLAKSE
The following text describes a protein:
Function:
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAVDYSRLASAKEKRQEQLKRWLESDTEREPTVPKRKRSRVKFQEGCVFLAACAAGDTEEVGQLLTNGADINTANVDGLTALHQACIDDNMDMVKFLVEKEADMEYPDNEGWTALHATVSCGHLEITQYLIESGADLSAVNNEGETPLDLAEDEEMEQLIHKFVEHQSIDLDAARREEERRMIEDANQWLNSRVIKEKKHSKSGASALHVAAAKGYIKVMQLLIQAGVPINAVDNDGWTPLHAAAHWGQKEACEVLAESMCNMNVTNFAGQSPFDIADVDVLPYLEELKKRQATIKKERPAEKLVIDITNEHEKAPLKRSMGSQSAPFSSYNGPADPELRTSVSRISLKDKTSFMQDISEERRTLESSILKKNKKQASSSEESSSEESSEETNSEDEGVDKERRQGGGVTLTRITPADTNQHGPTTTPTAALTHKPSDTDATATAAAASRKVLDDKAPTSWRAGLRKTGSSSAVPETNNGESKDKLQRSPSTPSIFYKPWEERLKEREKDKERERKESREDRLRRLGIMPPETKDNKDKTESREDRLRRLGILPPADNKDKDKDNTANTDTAGTSLYMRRKGGSESETAVARTGSSLTVTQSTAPSTVTTTTSTSNRRSYLAPQRDEESETQRKARSRRARETRRSTQGVTMDDLEAAEKTIRKDKEEKERRDKEGKENGTAKEVGLTGLHRQGRLGSGDYSVTTGPISTATPPNPPSVTITEAPDIQMTPDQDQDQNKGDKDKKLMSSQSARRRPREKRRSTGIPASAPTEDDGGSDETPSQSQPQENLIADGERTRSRYDTGTSSYLSRSTGSYRDRYGPYDSVKDKEKDKDYKKLYEDAVAENEKLKEKVNELKTELAGSKVQMERDKQRRDRFPDRSLLLETEKREKRALERRISEMEEELKQLADLRADNQRLKDENGALIRVISKLSK
The following text describes a protein:
Function:
Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing. Required for the endoplasmic reticulum exit of EMP46.
Miscellaneous:
MISCELLANEOUS: Present with 2900 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Domain:
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Sequence:
MMMLITMKSTVLLSVFTVLATWAGLLEAHPLGDTSDASKLSSDYSLPDLINARKVPNNWQTGEQASLEEGRIVLTSKQNSKGSLWLKQGFDLKDSFTMEWTFRSVGYSGQTDGGISFWFVQDSNVPRDKQLYNGPVNYDGLQLLVDNNGPLGPTLRGQLNDGQKPVDKTKIYDQSFASCLMGYQDSSVPSTIRVTYDLEDDNLLKVQVDNKVCFQTRKVRFPSGSYRIGVTAQNGAVNNNAESFEIFKMQFFNGVIEDSLIPNVNAMGQPKLITKYIDQQTGKEKLIEKTAFDADKDKITNYELYKKLDRVEGKILANDINALETKLNDVIKVQQELLSFMTTITKQLSSKPPANNEKGTSTDDAIAEDKENFKDFLSINQKLEKVLVEQEKYREATKRHGQDGPQVDEIARKLMIWLLPLIFIMLVMAYYTFRIRQEIIKTKLL
The following text describes a protein:
Function:
Putative phospholipase.
Subcellular Localization:
Secreted.
Sequence:
NDSQQIVIMNASYSDEIETTGWGKLNISTALPQGHSLVSDNNLAYFAGFIESTLTAERINQFWINFAASEFKNQQHTPSDELVQFISQQMTFVRNSIAENNATSEYWYAASLIMSQFDGLVNGYQSSPLPEMSEIELYLLTSAGDLETLVSLYPSTDKKSQPQPQPQSNNNFDYVKNCSALIRVLPGFSDVLFAHTTWRYYYGMLRIYKFYDLSFSKYIYKVSFSSSPGFLSSKDDFYISNGLAIMETTNDIFNSSLYQYVVPQSVLVWQRAMIACLLSYDSPTWINTFSQYNSGTYNNQWMVLNYNLFQTGKPLPKDSFWIAEQIPGYIEKSDLTDLLNQNQFFSSYNIPFFEYIYNVSGYPTVYSPTNQYSYQQCSRALIFKRNATMVSNFQDMKNIMQFNNFKTDPFSYSNPLNSISSRADLLTDRVGIPFGGVDSKVTSSSQVKTLSCTAICGPTTEGLPPFSWDNPAWSSVSHVGLPTVFDFDW
The following text describes a protein:
Function:
Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity). Induces flaccid paralysis in H.virescens larvae. Is not toxic to S.falculata larvae or mice.
Subcellular Localization:
Secreted.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
MKFLYGVILIALFLTVMTATLSEARCGPCFTTDPQTQAKCSECCGRKGGVCKGPQCICGIQY
The following text describes a protein:
Function:
Regulates spindle pole duplication in meiosis I, but not in mitosis. Required for meiosis I, meiosis II chromosome segregation and spore formation. Binds phosphatidylinositol (4)P mono- and polyphosphates.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MQKLLFVFSVLLTVVLATAPFQVQCPSSPLIREAKHELCPEETLYLKKKKIKTKNKLIQFLKSLTEAKFSSKFYKRVLKDPPKIGIAISGGGYRSMLVGTGFISQMNDYGLFEYSDYIAGLSGGSWILMDLVVQNFEVKSLLQEWDLEEDLLLGIPEFDISEEEIVTNAKKEYNDNDLKMKKRQGGSLITSSSNFYEQIEEIMNSIEEIPEDYMITKRNLNPLARLKKIFFPNNTFTGTDAKIETFKKVLDFYKSLHLKIKPKKMEGFQISFTDYWGKAIVQRLKKNFDDDPNHSFSFSKLVNSSKKFKECSVPIPIFVANCKNGLLSNVIFEFTPFEFGSWENILRLFVKLPYLGSKIVSGKAEKCINNFDDLGFITATSSSIFNNVLIFIWNLASQSSREAMKALNMVMGIFGLGKEEIFSISKDSSRLETDYAVYQPNPFYLYPEKDNVLTNKNHLYLVDGGEDGENIPLRTLVIPERELDVIFVLDSSSDIDNYPNGSKLKRIFEKLDEENVHYQFPNNVKTFTHPIVIGCNATKRTGHDSFLPIIIYHANANHGNASNTSTFKITYNQSEVSSMLPTGRGVFSNDYDLYYKNCLGCILTKRTMDRLPRKKKFSPFCLQCFKDYCYS
The following text describes a protein:
Function:
The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity). The carboxylated form binds strongly to apatite and calcium (By similarity).
Subcellular Localization:
Secreted.
Sequence:
AAGQLSLTQLESLREVCELNLACEHMMDTEGIIAAYTAYYGPIPY
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that facilitates microtubule-kinetochore interactions and the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MDQNKSTQATGNGKKTEEINELLESFIKEGPKLLWGSTNLKYEDQISRSSEHELQQYRELFTRLKFSYIEQGTKERYLRAILDDPPMLVEAEDNEKLETTNSSLKGRLKSEKREVDLLTEELKTTSRELSSNYESVMEECKNTKSTLSKLESLESELLKLQQDSSTKTPILPEVEAAIHDLESELNITNESIETIDGKIDNDEKYFIQLTKNLSLLEKEYKIASERSNQIKAAIHTRTPDADAKKQVQNWYTSMLEIYDQLLQK
The following text describes a protein:
Function:
Probably participates in a plant defense mechanism (Probable). Active against E.coli ATTC25922 but not against S.aureus ATCC 12600 or S.epidermidis ATCC 14990. Has cytotoxic and hemolytic activity.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
VLVASLVMLEAQSSDTIQVPDWGKRLLMNHDSNRVGIPCGESCVWIPCLTAIAGCSCKNKVCYT
The following text describes a protein:
Function:
Aromatic prenyltransferase involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity. Catalyzes the transfer of geranyl diphosphate (GDP, GPP) to olivetolate to produce cannabigerolate (CBGA).
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MGLSLVCTFSFQTNYHTLLNPHNKNPKNSLLSYQHPKTPIIKSSYDNFPSKYCLTKNFHLLGLNSHNRISSQSRSIRAGSDQIEGSPHHESDNSIATKILNFGHTCWKLQRPYVVKGMISIACGLFGRELFNNRHLFSWGLMWKAFFALVPILSFNFFAAIMNQIYDVDIDRINKPDLPLVSGEMSIETAWILSIIVALTGLIVTIKLKSAPLFVFIYIFGIFAGFAYSVPPIRWKQYPFTNFLITISSHVGLAFTSYSATTSALGLPFVWRPAFSFIIAFMTVMGMTIAFAKDISDIEGDAKYGVSTVATKLGARNMTFVVSGVLLLNYLVSISIGIIWPQVFKSNIMILSHAILAFCLIFQTRELALANYASAPSRQFFEFIWLLYYAEYFVYVFI
The following text describes a protein:
Function:
Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids; The DnaA box is 5'-TTATC[CA]A[CA]A-3' in this bacterium cycle. Multiple discrete DnaA-oriC complexes can be seen as DnaA levels increase. Binding of DnaA to oriC is increased by HobA; some chi-type structures can be seen by electron microscopy. Strand separation requires the DnaA boxes and adjacent DnaA-trio motifs but works equally well with ADP or ATP.
Miscellaneous:
MISCELLANEOUS: Estimated to be present at about 3000 molecules per cell (in strain P1).
Subcellular Localization:
Cytoplasm. Cell inner membrane. Note=About two-thirds of the protein is found associated with the cell inner membrane. Nucleoid-associated protein is probably in the cell inner membrane fraction (Probable).
Domain:
Domain I is involved in oligomerization and binding regulators, domain II is flexibile and of varying length in different bacteria, domain III forms the AAA+ region, while domain IV binds dsDNA.
Sequence:
MDTNNNIEKEILALVKQNPKVSLIEYENYFSQLKYNPNASKSDIAFFYAPNQVLCTTITAKYGALLKEILSQNKVGMHLAHSVDVRIEVAPKIQINAQSNINYKAIKTSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNAIGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQIVLISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQITLPEEVMEYIAQHISDNIRQMEGAIIKISVNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLAQFLDLKDHSSISKMYSGVKKMLEEEKSPFVLSLREEIKNRLNELNDKKTAFNSSE
The following text describes a protein:
Function:
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MMASDPDAGVPNLNLSPEEKRVYGQLFRAADTDSVGVITGEVAVKFFERTKLDSRVLGEIWQIADKENRGFLTPAGFGVVLRLIGHAQAGREPSPELALSQGPIPRFDGFTPTPAPVPVPGPAQSPAVPAAMVSPQATGSGPIRIPPLTPEKVAQYSALFERQPLLQGNMLPGEQAKQIFEKSGLSNEILGRIWMLADTEQRGALVLTEFVIAMHLLTSMKTGALRGLPTILPAALYEAATRRGPVGGINPPPGRSPTTATPPLPPAARHLTGPAQLTQTRTGSPLGRPPLPAQPTGDWLITPADKARFDLLYEELDKQKKGFITGEEAVPFFSQSNLNEDVLAQIWDLADINSAGRLTRDEFAVAMYLIREQRTKPGQVPLPTTLPPNLIPPSMRAPQGRPQTAAGGFQPPRPQPPAPKPSALDDLFGLDEPQPPAPGPAPVQVPIATGGSVDPFGNSASPIAPSSPIRPVATGSNFKPFVPSSSFGRGLTTHVTGGSTGSAPAGGVRTSPMPPTVEDDLLGDADPEVNNKLSNETTELANLSNQIGSLTKQVQDVQTQRTNTQNELSQASQQKKNFEQRLTQLRALYEKEAQDVRALETQLSTAKAETKKLQTEFAMIEASYLELQNQHRTVVAGLQADQQENASLKEKIRTVNGEIAQLKPLVEKLKSEARQQKGMVAINKKQLSTVEGEKGKLQNEVEDLNKEKEELARQVDLARQASPVQPVASPALSTGSGNNPFFRRTGSADIGAAFASRSMSGQSFDDVFGPSLNVPVQSPTPPPAAASPVPQVQAFKAQNTGTSTGSFGSGSFATPGSTSPTLSRQPTITAESTAAPGGAFSPFGEPSGSGSRAPSRHGSRDQAPAAAAAAAAALPIEPVRTGQSATSNRPMSPASITSQSKPAAVPVEADPFAVNTDAKAKEDFESAFASFKNTQAKPAAAAETAKAGGFNKVDSEFPPISELERDDESDSDSEAGEDKGGFGFDDDFAPASPVKPPVGAEAGQAETVTAPAAAEPVASETPSFTTAPVTSTDSPAALEVSNTENRSTSAAATSNTNLDDIWGTGSPAPATAQPPAAAQPPAAASQASSKGAFDDLDDEFADLEDAKEGSSADDVEDFANISRSGFGDDGFGSGSQFGSPPPSQPKSDFDFVPSHQATQSQGSFAAPKADAHDWDAIFAGLDDGSQAQQGGQSPFESLETPRPGSSANPQAQTGGEQKEGGDKEQKKEGAEERPVPGRALTESGEHDDPIVKNLTSMGYSRQDAVKALEKYDYNLERAANYLASQS
The following text describes a protein:
Function:
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Sequence:
MVTWIRGEELHARTKEWARSHVKRLEEVGITPKLAVLLLNDDPVELETQRRFVTLKARDVREIGGEVEIYELYSAPPERRTKEALRLIESLNRRDDVTGVIIQKPLPPFVDEKALFSALSPEKDVDALTPENKKRLLTDFDLDRDVLPCTPAGILELFKLYGIDVRGKDVVVVGKGELVGKPLAVMLMQLDATVTVLHALSKEREPYVKRADIVISAVGRPPELYKDNPWRLTGDMIKEGAVVVGVGGKVDPATKRWFFDVDEKSVAEKASYLTPNIGGVGLATRARVLKNLIRTTYQVAQRVLSPRLYEV
The following text describes a protein:
Function:
May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTNETTTAQQPTSNANTGIKIKKTLNGNNKVESLIVDSGPLIKGHQLVHLANSFYTVREVLDEIKDQNTRDMVASLPFDLVVRNPSSEAVAAVAAFSKKTGDYTSMSTTDMKILALTWMIEKETNGLSHIRSQPLHAMTSNGTNNDAKPVPKPALQKTQNIAVDQNVEPLVEAVKSKSSDNVTKTNSKKKQAKVAAEMDDDAGWITPQNIAKHKAKDLYGSISVKNAAKAPSVACMTTDFAMQNVLLQMNLNVLSVDGITVRKLRSWVLRCHSCYKVTKDMNKQFCPSCGNSTLNRVSVGINANGQTIYYLKKNFQVNLRGTRYSIPKPKTGRNANNLIVCEDQKEYQRALQQKQRRDKQLLNQDSMSLDSAILGSIGHKNSDGGPSLLTKSGMPLVGYGHRNVNASRGRRRK
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, telomere.
Domain:
This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (By similarity). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase (By similarity).
Sequence:
MTDHLIAKVQEHVPNIPLKIISQGAEALVFETSVHPYYNYNSSEKHHESPSLHNHTTFIIKYRPTKPYRHPKIDLQINKSRTIGEVKFMYKLSKLNIACPNIISTDFNNGIIWMECLGSKLPNGTISSFKNWLWYLESQEKEDPSINLHDDDQVELVCQKVGQLIGRLHLNDMIHGDLTSSNIILTEVDTKKNEDTDANNSSVYFEPALIDFGLSSFSGLAEDKAVDLYVLERAILSTHSNYADKLNGWLLEGYQQIHDSIEFNKTKQQLGKSKLKDTIKRLEDVRLRGRKRSMLG
The following text describes a protein:
Function:
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MQDSTLITIIFIFFYFSWNFYLHSRLVYVNSNDFESEEILNNFEEAEKRLNAILHGDHERLNDMWEIVRESIPKRWTEPIPVLVFACNRPAAIRDHLEKLIRLRPSKESFPITVSQDCDSSKVADEVKKFGDQVEYIKHTPGINANIKVPPRFKKKKSYFYISRHYKLALTHMFSKNPYSTVLITEGRIMNSNFNLIIYPNLSDDLDIAPDFFSYFSSTRHLLEKDPNLYCVSAWNDNGKLEHIDWNANATLYRSDFFGGLGWMMARRQWEEFEPTWPAVFWDDWMRDPAQRKGRQCIRPEISRTGMMIHGKKGVSNGQFYADHLSKIKMSNFSINFEELNLNYLLPNNFKNKMDKDLADAVLVELENITSSSWKPEVKNLKVKIVYTGKAHFVNITKELGIMNEFRSGIPRTAYNGIVTCFFKKTRLFLVPDRSKVPIYD
The following text describes a protein:
Function:
Functions as a receptor binding protein (RBP) and probably mediates the attachment to the host capsular exopolysaccharides (Probable). Displays a depolymerase activity that specifically degrades the K63-type polysaccharides of Klebsiella pneumoniae capsule, which allows the phage to reach the host cell membrane and bind the entry receptor.
Miscellaneous:
MISCELLANEOUS: Does not affect the antibiotic susceptibility of Klebsiella strains. Exposure to the depolymerase of the phage induces mutations in the cps (capsule) locus of the host bacterial population.
Subcellular Localization:
Virion. Note=Tail appendage.
Domain:
The N-terminus anchors the RBP to the virion.
Sequence:
MALYREGKAAMAADGTVTGTGTKWQSSLSLIRPGATIMFLSSPIQMAVVNKVVSDTEIKAITTNGAVVASSDYAILLSDSLTVDGLAQDVAETLRYYQSQETVIADAVEFFKNFDFDSLQDLANQINADSESAQSSAAAAAASENAAKTSENNAKSSEVAAENARDQVQQIINDAGDASTLVVLANPDGFRHIGRCKDIATLRTIEPVESRQVIEVLSYYNGLAQGGGTFWYDPNDSVTEDNGGSCIVTNGGKRWKRIIDGAVDVLSFGAKPDDISFDSAPHIQAALDNHDAVSLYGRSYYIGSPIYMPSRTVFDGMGGKLTSIAPSTAGFMAGSIFAPGNYHPDFWEEVPKVAATTTLGSANITLADPNIVNVGDIIRLSSTTGVLSAGFFVSEYLQMARVLSKTGNVITIDGPVESQLTLVAANANQPGYLARFNKPLFCCVDSIIQNIEIDTWDYWTADSATYNVKFSNIWGSAKAVAYGNTFCRSLFEDIRIVFSGRVSELAFGSHDTNLVRITAIASPKGLSASVVFGWAESGRRCTIDTFSIMLNANANPSTVIRVSGHRDSLIKNGSIYVHNNTNNILSVENYGTTADGVRPDCDNITFENVSIFVTGSSAVVCDVYKSADNSVIKNVAFKNIKYFGPTPSVALYRARGTLANFVKGVQANISSDTGGAIVLSNSENNVLTFTGPVSVTSLVSAAAKNTLSIRNYARSSAKANNFTQESTLNVTDTTANAVSKEFTYPAGSLRINDKIKLSLGGSTAGTVGKKTVQVGFIGSDGAFKYVELAALATDQVYWTMEVEISFLRTTNSQTNELETSAIITSFLSKGAATGAALSGSRALAVVSDLALSNFVVQVRAWKENAADGLSLSRMNLQLEDLTA
The following text describes a protein:
Function:
Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEGADGGGDGASARSPGGSPGGDGFAPSALGTREHWDAVYERELQTFQEYGDTGEIWFGEESMTRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKSGFSNITGIDYSPSAIRLSGSIIEKEGLSNIKLKVEDFLNPSTKLSGFHVCIDKGTFDAISLHPDSAVEKRKQYVQSLSRALNVKGFFLITSCNWTKEELLNEFSEGFELFEELPTPKFTFGGRSGNSVAALVFQKT
The following text describes a protein:
Function:
Bacterial cytolysin that attacks host cell membranes and causes cell rupture by forming a pore. Binds and permeabilizes target cells by forming cation-selective pores. Constitutes the key virulence cytotoxin of K.kingae. Binds cholesterol and oligosaccharides on the surface of host cells. Does not bind beta-2 integrin (ITGB2) on the host cell surface.
Subcellular Localization:
Secreted. Host cell membrane; Multi-pass membrane protein.
Sequence:
MNLATTKAKLKSGAQAGVQALNKAGHAAKTGTVAAGKATVAGAKSLYLTIPKDYDIEKGGSLNELIKAADELGIARLQEDANNIESAKKSIDTVEKLLSFTQTGVAVSAKKLDELLQKYSSSQLAKSLGSSANIDSKLTKTNHILSTLSSFLGTALAGMDLDSLVKQGDASATDLAKASLDLINELVNNISNSVQSIEAFSEQLGRLGAAISQTKGLSGLGNKLQNLPNFGKANLALEMISGLLSGISAGFTLADKNASTEKKVAAGFELSNQVIGNVTKAISSYVLAQRAAAGLSTTGAVASLITASIMLAISPLAFMNAADKFKNASLIDEFAKQFKKFGYDGDSLLAEYQRGAGTIEASLTAINTALGAVSAGVSAAAVGSVVGSPVALLVAGVTGLISGILEASKQAMFESVANRLQSKILAWEKENGGKNYFENGYDARHAHYLERNLKLLSELNKELQAERVIAITQQRWDANIGELAGITKLGDRISSGKAYADAFEDGKKLDGASNVTVDTRTGVVDISNANGKKTQALHFTSPLLTAGTETRERVQNGKYSYINQLKFNRVKSWTVKDGEANSRLDFSKVIQHVAFNDEDGRLSGKTEEIALNVNAGSGNDDIFAGQGKMNVDGGTGHDRVFYSKDGGLGQVNVDGTKATEAGSYTVNRSINNGSFYHEVIKRQTTQVGKRTETLEYRDFELKRPEHGYQTTDTLKSVEEIVGSQFSDTFKGSKFADIFHGGDGNDTLEGNDGDDRLFGGNGDDHLYGGNGDDLLDGGKGNDVINGGDGNDVYISRKGDGNDTLYDSHGSDKLAFADADLSELTIERTAQGIMIKRNDGSGSINMAEWYKTLSQQNYHGNATDDKIEQIIGKNGDYITSEQIDKLLKDKQTGTITSAQLQQLAQENKSKSIDSGNLASTLNKLIESMASFGSRGATASNYLQPAHKSPQNVLAPSAV
The following text describes a protein:
Function:
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.
Sequence:
MTFSQSLRKEVDSIWEASFNHPFVKKLGEGTLDLASFRYYVLQDSYYLSHFARVQTLGAAKALELETTARMAHHAQNTYEAELSLHENFAKKLGITKEEKDNFIPAPTAYAYTSHMYRAAYEGHLGDIIAAILPCYWLYYEIGERLKECQPEEPIYNEWISAYGSDWFRTLVEEQITRLDTIAEKVTEADRKRMKQHFIISSQYEYSFWEMAYTLEKWPVDTDVKDVIG
The following text describes a protein:
Function:
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MSEPLPSSFDGHEQFQEETPLQKFGRRFKEEPWVPAVGLLGCAATCYALWRAYRSMKAGDSVEMNRMFRARIYAQGLTLLTVVAGGLYYRTERTQRREFEQALELRKGQEKRDAWLRELEIRDKEDKEWRERHAAIEAAAKQAGNKPVLAEQDAARSALEPSEQKYYGVLDAVRDLVSRRE
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.
Sequence:
MKNYFNEEEDEIAELAAGQLLVTQECDIPKNETSSLVCVDADAIDCDNASTRVRPRTVGEDLNTEEGNSAAPHLTSLSHEHDPCFPVDGFDSKMIFSEHVTRISCHEAPLLGESQLNCALRDGPPSSAEVVDEHMEECSPSSPTPDIADAGVILNDLTPTNCFSYSEMSDIGIVVDYVVYRGKYCTGCLVTFSYSGIKINGTTAHGDEGTFSFETGIDEIVSIESQNIQRFETVMIKLHILSKDAVQADNTQGMSGVEELEVVVVEPNWSRKWEEITSLNVKYSPLLSVIHDMDIAMNGVDSLQQRRYFPSFDSEFEDVIYPKEDSDAVSISKRDVDLLQPETFINDTIIDFYIKYLKNQIPSEEKQRYHFFNSFFFRKLADLDKDPSNVKDGKAAFLRVHKWTRKVDLFGKDYIFIPVNFNLHWSLLVICHPGEIAGVKDEDTEISVKVPCILHMDPIKGTHAGLKNLVQSYLWEEWKERQKGSSEDMSSKFLNLRFVPLELPQQENSFDCGLFLLHYLELFLVEAPVNFSPFRINGFTKFLNGDWFPPAEASLKRTLIQRLISELLQNCSREVSSSGCSSEQQSNFPEINGKESGLELVSDRYSPDGACRVNLSSSDHGQGIEITLLGVSPMRNSHCVNDPGLVLREFFDPEVAAGSLLAQCPSFDQPSSYHHLNGTRSQIEQDDTETGEQFVYFPSGETVFQKVAGITPQDGSISCSFKGFGADDSWNPGISLQADDNDSSSETSDCASDDSDVGIIENFPAMEDAGICQKEKFDQRKSPLMENVGCLTVSLASASGEMLENSAFGGIRNLRSTEDIDKIHDGNEHVSLASCQGNFSASLQEDPNLVEIVLNQDLEKAKVTRDNMQAIEGIHNLEGIDDTDRIRYDKENGNIATCQENFSASLQEDHALVENGLHQDLQKTEVIENDMQTIGDDVMMVESDEQQAAKRPRRTS