lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MALVFGNIHAVPKSSQELIDTVLSSTNRKTATIIHPGFKISRIRDFYMNKVNFARDQFTSRLTQILEDFPRLDSIHPFWASLINVIYDRDHYKLALGQIIGAKTLIHNVGRDYVKYLKYGDSLFRCKQLKKAALGRMCTACRRLTPSLQYLEEVRQHLQRLPAIDPSAPTIILAGAPSTGKSSFMNQITRANVEVAAFPFTTKSLYLGHTDWAFLTWQVIDTPGLLDRPLEKRNTIEMQSVMAMVHLRAAIVYMLDISGTCGYSVEQQVSLYHSLGEIFANRPVTVVLTKTDLVNPDNMSPEDKALIDSMQGPNVSFMRMSSMTGDGVSEVKEHVCQGLRKMRVDSKKNSDKISQIESQLHIAKPEQTYEPNIPASVANPQGLGRPTQKELEEMAGGAGQYAANTNAERDLKNPEWQNDVMPEIIEGRNIADYIDPDIEKKFAALLEEEKVRYQNYQAVKQAFEENKWKVTPEQEEMVSIIRERRQMIRNKAEEKRNGRPGMPEKMKKQSKSVIADRVDSMLQERGVDESARQRAVDKVLSEKPSRVERKLEPEKRDTGIVKHGAGERFDYYVKTNYILEPKFLFSGKAGFKRDYK
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWSPNDVSEILVVFCKIWTCFGLPVYKFNVQGNFCLEKSLTFFVLNLSILTVGLLLHVVFIPVANNLWSHISFCQYCIHYVQTFGIVIFSHVKRKEFEEIFNDLLAIESKIRLFGGGSFGYHKLGKELVVFVIQQSLLVTILAIANFFTTAETTEIVLYLLGYYFGYLSNFHFGFFLLIMPKIGFKLYCDFINSINGQPVKNVMKMYGKLYSLPVSLVKTLQGFILLRVFSTFTIATLDIFFAISLVIPQELPWFKTFCLIFVNILWLSGLLLNEFLILLYFEKMLEQKLVICRLIRNNRPVRYKYLDLIYLRFNHEPRHFTVCGLFPLKCTLIFSVVAGVATQVTYLFQFVNKLEQ
The following text describes a protein:
Function:
Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc).
Sequence:
MTRDLTITAVHLTPILVADPPLLNTQGVHQPYTPRLIVEVETADGVTGVGETYGDAKYLELARPFAAKLVGRQVSDLNGLFTLADEVAVDSSRVFGQVDVGGLRGVQTADKLRLSVVSGFEVACLDALGKALGLPVHALLGGKVRDAVEYSAYLFYKWADHPEGVASEKDDWGAAVDPAGVVAQARAFTERYGFTSFKLKGGVFPPEEEIAAVKALAEAFPGHPLRLDPNGAWSVETSLKVAAELGDVLEYLEDPALGTPAMAEVAAKTGVPLATNMCVTTFAEIQEAFTKGAVQVVLSDHHYWGGLRNTQQLAAVCRTFGVGVSMHSNTHLGISLAAMTHVAATVPDLHHACDSHYPWQSEDVLTERLAFDGGKVAVSDAPGLGVALDRERLAFLHRRWLDDDGTLRDRDDAAAMRVADPEWVTPSVPRW
The following text describes a protein:
Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Involved in cell wall biosynthesis (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKQDKRKYSGFVQSVGITCVLILIILWTLLPYPLLDPEKRLAEPQTTTESISLFLDELVELFPQRYWIICIQCMILMDMLFVYIGLPIFNQSVLTVRLDDLRTITDSKASVVMCESHAEFLTSYAHTETSGVYDLPITEVSRLLYGKARHKSD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Subcellular Localization:
Nucleus.
Sequence:
MQRDQPLKVRSGNEQWPESSMQPAGGGGVGAGAWNHSREALELLETQLRCSRCLNILREPVCLGGCEHIFCSVCVGDCIGTECPVCHTPAWIQDVKINRQLDNMIQLCSRLRNLLHNTTGTDEEESTPRTRASLDEDENNKKFIKMWFSPRSKKVRYVLNKTLVQTQPQPVENEQDYQAFEFSSSSLEKDSPQRPKKVTRKTRKKQKKRSLVEINKKWDLEEEKQKEIHQPDESFNEKPKEKSVSFCNQPSVLGTPENPPVLNGDLLDHGSVTEAVPTAVVTESSPLPVTQADSVEMDRDSEVASSHPESFCEDNFTSETSLPLRNGGAWERQQPNSFVVPVSKRPRRRRSQQRVRRASLSSDVPLESLTPREESAPSPTSKSLADEPFLRVRNSDVLNDSINFSPHKSSGTSSSSLLNSPCQPWIVSSPSVVKMSPTSPMTVKRNHRGETLLHIASIKGDIPSVERLLQNGSDPNVKDHAGWTPLHEACNHGHQKVVELLLEHKALVNTTGYQNDSPLHDAVRNGHVSIAKLLLSHGASRSAVNIFGLRPVDYAETEAMKSVLLLPEESEIYEIGQCSKSLNTSYRRDDPLVLLSSGLTSDQQKLLSKLSAVLKAKKCTEFNSMVTHIIVPGDTAQRTMKCILGIISGCWILKFDWVKACLESRMCEPEEKYEILGGPQRSRLNREQLLPKLFDGCYFYFEGIFKHHSKDELVKLAKESGGQILNRKPKPDSDVTQTINTVSYHARPDSDQRFCTQYIIYDAFSNYHPERVRQGKVWMAPSNWFIDCLMAFQVLPVTK
The following text describes a protein:
Function:
Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (By similarity). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Does not interact with ALG-2.
Subcellular Localization:
Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted, extracellular exosome. Cell junction, tight junction. Midbody, Midbody ring. Note=Colocalized with CEP55 in the midbody during cytokinesis and at centrosomes in non-dividing cells (By similarity). Component of the actomyosin-tight junction complex.
Sequence:
MASFIWVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRSALGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKTAAKQYQFASGAFLHIKDTVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPTLAAKQCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKNVASRYDEYVNVKDFSDKINRALTAAKKDNDFIYHDRVPDLKDLDPIGKATLVKPTPVNVPVSQKFTDLFEKMVPVSVQQSLAVFSQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSTSVVEQGGIQTVDQLIKELPELLQRNREILEESLRLLDEEEATDNDLRAKFKDRWQRTPSNDLYKPLRAEGAKFRAVLDKAVQADGQVKERYQSHRDTIALLCKPEPELNAAIPSANPAKTMQGSEVVSVLKSLLSNLDEIKKERESLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRIYGGLTSKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPPPAYQSSPAAGHAAAPPTPAPRTMPPAKPQPPARPPPPVLPANRVPPASAAAAPAGVGTASAAPPQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPTYPFPQPPQQSYYPQQ
The following text describes a protein:
Function:
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Subcellular Localization:
Cytoplasm, perinuclear region. Cytoplasmic vesicle membrane.
Sequence:
MDAGKMTVSINKAINTQEAAVKEKHARTCILGTHHEKGAQTFWTAVNRLPLSSNAVLCWKFCHVFHKLLRDGHPSVLRDSLRYKSELIDMSRMWGHLSEGYGQLCSIYLKLLIIKMEFHTKNPRFPGNLQMTDRQLDEAGENDVNNFFQLTVEIFDYMEWELNLFHTVFKSLDMSRSVSVTAAGQCRLSPLIQVILDCSHLYDYTVKLLFKLHSCLPTDTLQGHRDRFVEQFQKLKDLFYRSSNLQYFKRLLQIPQLPENPPNFLRASALSEHISPVVLIPSENSPPDSETLIETEDLVGMDTLSHQSLSENTFDDIFGSSFSNDPFNFSNQNGMRRDDKDHLIEQLYKEIAMLRDEFGNFKSESHRLVTNLKGRIQELEAELAEQKHLREQAVDENEFLRTELEDLKRRREDTEKAQRSLTEIERKSVANEQRYTKLKEKYAELVHSHADLLRKNAEVTKQVSVAREALVDTERSKKELEDSYQRVNEHTQRKAHEQIKEMDQLQGALESNKQEIHLLKASIEASKQEGQIRIMELKESVIDRVLQEAEFIIQESLRQLDEPHYSSGMISTDFLITRALAAVQSTEKMEEAWKAHMANPSDITLLLPPLVQFAHRISEVILQGALTPTSDRLNDGCRTCGTEALSYLSSLQKNETEGSVHCSRVTAALKNISEIAQELRPPTLDIREEELGDLVEKEMAATAAAVETAATRIEEMLNKSRTDDTGVKLQVNERILGSCTDLMQGIQALILASKDLQKEIVESGRGAASQKEFYARNSRWTEGLISASKAVGWGATVMVDAADLVVQGQGKFEDLIVCSHEIAASTAQLVAASKVKAEKDNANLSRLQQASKVVNQNAAGVVASTKCVMSQIEEKDTMDFSSMTLTQIKRKEMDSQVRVLELENELQKEREKLGELRKKHYDLAGVSEGWGDAAE
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MNSLRLTLCCVVVVLGALPYFSYAQLDPSFYDSTCSNLSSIGCDASILLNQTDEIDSEQTAFPNDNSIRGLDVVNKIKTRLENACPGIVSCADTLALAAEVSSELACGPVWEVPLRRRDGFSANQTLANENLPAPSLCIDQLISAFANQESLQVICSNGGPESDLTNLDLTTPGTLDSSYYSNLQLQKGLLQSDQELLSANGTDIVAIVNSLTSNQTFFFENFAASMIKMANIGVLTGSDGEIRTQCNFVNGNSSALTTKESSQDGMVRWAKVMLENAGIKGGVNKEFCVCMW
The following text describes a protein:
Function:
Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate (PtdIns(3)P) which is necessary for peripheral membrane localization.
Sequence:
MNDKISFLPPEPIQLLDEDSTEPELDIDSQQENEGPISASNSNDSTSHSNDCGATITRTRPRRSSSINANFSFQKAHVSDCTIVNGDHGTKFAVWRITVFLEPNLKAFAAKRESYKIQTYKRYSDFVRLRENLLTRIKTAKPEKLNCLQIPHLPPSVQWYSSWKYQEVNLNKDWLAKRQRGLEYFLNHIILNSSLVEMTKDILIQFLEPSKRVA
The following text describes a protein:
Function:
Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity (By similarity). May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus envelope. Nucleus inner membrane. Note=In spermatids, it is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm.
Sequence:
MRRNPRPGSAASSHNHTPNFYSENSNSSHSATSGDSNGRRSAGPELGEPDGRMARGSSCGEPALSSGVPGGDTWAGSSRPKLAPRSHNGQTACGAATVRGGASEPSGSPAVLEEQLNLLPILDLRQEMPPPPVSKSFLSLFFQVLSVFLSLVADGLVCVYREICSIRFLFTAVSLLSIFLAALWWGLLYLIPPLENEPKEMLTLSQYHHRVHSQGQQLQQLQAELSKLHKEVTSVRAAHSERVAKLVFQRLNEDFVRKPDYALSSVGASIDLEKTSSDYEDRNTAYFWNRLSFWNYARPPSVILEPDVFPGNCWAFEGEQGQVVIRLPGHVQLSDITLQHPPPTVAHTGGASSAPRDFAVFGLQADDDETEVFLGKFIFEVQKSEIQTFHLQNDPPSAFPKVKIQILSNWGHPRFTCLYRVRAHGVRISESAEDNAMGVTGGPH
The following text describes a protein:
Function:
Catalyzes the NAD-dependent stereospecific oxidation of (S)-1-phenylethanol to acetophenone in the degradation of ethylbenzene.
Sequence:
MTQRLKDKLAVITGGANGIGRAIAERFAVEGADIAIADLVPAPEAEAAIRNLGRRVLTVKCDVSQPGDVEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTFEQWKKTFEINVDSGFLMAKAFVPGMKRNGWGRIINLTSTTYWLKIEAYTHYISTKAANIGFTRALASDLGKDGITVNAIAPSLVRTATTEASALSAMFDVLPNMLQAIPRLQVPLDLTGAAAFLASDDASFITGQTLAVDGGMVRH
The following text describes a protein:
Function:
Regulator of cell matrix adhesion having two related functions, one upstream of Actn organizing the Z line and the other downstream of integrins regulating assembly of integrin adhesion sites. Also required for the formation of myotendinous junctions in muscles.
Subcellular Localization:
Cytoplasm, cytoskeleton. Note=Regulates or strengthens the link of integrins to the actin cytoskeleton.
Sequence:
MAQPQLLQIKLSRFDAQPWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNFVITVQRGGSTWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPFSNGGDGGVKSIVNKQYNTPVGIYSDESIAETLSAQAEVLAGGVLGVNFKKNEKEYQGDRSEVLKFLREEETGQSTPAFGNSHYEHDAPQQLQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSAPVNSPKPPSTGGLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQAAINNPPTGTEGYVPVPIKPNTKLSASTISSALNSHGYGGHSNGYSNGNSTPAPAPVASSQATATVATVAPSAATAATAAATPQAATATDSPAATASSSDNMSAYVADEPSSIYGQISAESVALAPPPPQPPTAGGGDQPFEYVTLTGNVIRSVQAPGKGACPSYKVNQGYARPFGAAAPKSPVSYPPQQQQQSPRPAPGGQNPYATLPRSNVGQQGGEAVEELQPEFEEEDCYEMDIEVALAASRQSQRGSSFTWPPPQDDSHLAPTAAPLYIPPPETQHVVVSNPVQQVPPLPPGGATARLDPQPVVGTSANGAPQWQSYSAPQLTTASARQLAEQESSSDSYTSTSTTTTTTSEEYQRMYAAQVQAYQMQEQSGSEFDYQVDYASTQDSVQDYPSGRRSAQECVDSLAVPLSTYKLVDMVREVTPSPVTTPTQTPAPAAPTTRRVVFNDEPEIKELPQLPAELETIPEASEAVEDREGLVIEQRCQILESERKFQPTPEIKIEIAPVRQIPPTKIPNPMPKEWINPMIRVLTTAPEVPFHLVECPFPRPCGDDFEAEAAAAEAAKTQEVPEPLPPQVSAAPPATVSVEPSPAPLRESPPRGSRLSQAMVTAPEFELKFAPPADQGIPLPEETEPYMPPPIDTKPYLREDYRPKSPFVSALTTAPDRPFEGHFDKDVPIHMIDLPTPKEHLSMCDALCTAPERGYTPLNPENAMHRVDEEQKQQELKKREFQVLDHEEELGIRPEPPQSVEYYETRRDQPRKSSAFAAMQAFQPSREPLSSNTVSNAGSVADTPRASIVSALKEETDLEYQKYLKAQQRNQKRLDYFHQKEEELSGLQGQQLTQLQRELSNQQQNLLSQQQLQQSKLLQLQQCVQSQELQQQVQHLTQKSQQQPPQANQQQQQQQQQRGTQQQQHSQVTQRTQQQQQQVPQQVTQQQQQEHSLLSQTTLAETQTLQANAQSQSSASYSSKATACSNSSSTVPPANTSTAFAPAPAPAPTSIPVRPSAIAVQSSYCSSQFDVHELIEETAEELEHSEVLFPPPSPLSHLTKQGKAVQSGLHKADSIPKYQRNWTVLPTQSPIRTPEPQELRENVPLAFVDAPKAPVTSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQLSVPIIVEDRSGPVTMAFQPLDELVRPDQALTPTRPYTPSLTNKPAPIVPFYQTEEKLVFEECSATHARNYNELNASPFPDRTRSPAPGPPPNPLNAIRAPRMKEPETKSNILSVSGGPRLQTGSITTGQSYQGQLLAHSEQSSQSASQSYNQQPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQTRSQVGNTQIERRRKVTEEFERTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQAQSQSQNQSDTERRSSYGKTGFVASQAKRLSCMEEEISSLTSQSQAISARASALGEGCFPNLRSPTFDSKFPLKPAPAESIVPGYATVPAATKMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRPSIASITAPGSASAPAPVPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKNHAR
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTPLAPSSFKGQLLLALMLSIGLKVLTFSLSTILTRLLLPYQNGVYFTFNVYNDAVLFIAREATRNVASRLPIIEPSAEAEDSAEHHGKGGAAHEMSPAERGRAPSAPSASSARTPASLVRVANVRAVVSIAFCSVPLAIVVAAVLEALGTCLGVASFVPSMMQHARASQQVFRKAENASGLDGASTLTGLPFLLLPYMPEMTVVLCAVLMAAVEPCVVLVQSLNLFRVVVLAECATLVARLCTIIGIVYACQRYSAGGRTPHGEVGNGLRTMWEARMALAFGQLAYAITHVIYYSLVLSGLPVARWLGCSTAMEQVRAAALLAHARDMRQSEQDTGAGGSAGDAKAAPSSALAAPLQAGRWATFAFPFCFYSIVDSVAVCRRYAALFSTFLRESLLRLVLSEGESLTLTSLGSETARGYYQLISSLGSLVARLLFRIWENACFVKWSREASLGHRHTAVQLLKLMLRLAFYVSFSFTLLGPPLAKTFLATMYTSRWATPQVSTALQLYFYDLPLMAWNGLLEAFLRAVASPAVLHRLQGWMVGETVLYIAACYVTLVAFGKADSQGESVSVLVLLNIFNTLWRCGVSIYLLVSSPGAAVGAATAASTSAQAKDGGEPAAPALPSLAPPSPIVHLRDFVSLFPKHVLGSILGIFVCSRVLRENSVVTITAVGLAYAAVILAWDGEVRQLLVTPAWSRMRPLLLGAPMARTRA
The following text describes a protein:
Function:
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Sequence:
MLKTSEKIFSETPSIITKEEGLKILNGVIPLTTCLDKAFQERNRYFENKVRIHILDNIKNGYCPEDCGYCAQRKNANSGVQEYPMKSEQEIYEDAVQAKKNGAYRFCMVTSGTGPNRLTTEKLASTIQRITDELNMKVCLSAGLLDIEKAQVLKEAGLDRYNHNLNTSENHYSEICDTHTYLQRTQTLDSVSKAGIGMCSGVIVGMGESFQDIVDVAFQLKSFRVISIPVNFFIPVKGHTIKNPSVLTPELCVRILCMFRLINPDSEIRIAAGREGHLRSLSATALFAANSLFSSGYLNVKGSEILETVAMIRDAGFVPELSNGEILPENFGTESFYSEKNFPELYKFKKF
The following text describes a protein:
Function:
Extracellular signaling peptide that may regulate primary root growth rate and systemic nitrogen (N)-demand signaling.
Subcellular Localization:
[C-terminally encoded peptide 13]: Secreted, extracellular space, apoplast. Note=Accumulates in xylem sap.
Sequence:
MARPRISISMICLLILIVGFVLQSSQARKVLVPYGTSKGLFLSALPKGNVPPSGPSDKGHTSPPDDTDQRMVPENSPEIYRRLESVPSPGVGH
The following text describes a protein:
Function:
Plays a role in primary ciliogenesis by modulating actin polymerization.
Subcellular Localization:
Nucleus. Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized with TTC17 at F-actin rich zones and at dynamic plasma membrane protrusions.
Sequence:
MGDVTRGEWVVWGLEAGPGETASLHHPGLEDMLLFFPETLAILSDTGEPQGELTIEVQRGKYKDDIGILTHCLLVHASSRGFLDKSLCGSSLLGYLNNNLELMEQHSQEFIKFPVLPMERKMSVLKQDGQFVVTRSVKEGEETKTGVSVFPYKTFKGFVSSAANVVLLRVMAWQQSVPSGARFLALDSEGKLCHCTYKSLGFQTIQVGNQQAKMFIVEQTIHSEEGIPFSCQYYLLPDGHLAKRVQVGSPGCCIITKMPLIREEDVIESPPTFDKKPLVWGEDLELYSKFLDRKEQLRLSHASYLRHHPEAQALVSDFLLFLLLRRPEDVVTFAAEHFRPFAALRSPIPALRSSHQPSPFRTLENEEEEEAKEEEEKEEEEEEEEEIAGEIEGEEEEEEIEEGDDYLYMDEDEDIEDYTYYENYYYNYDEEVDSYDDVNNYDDDDIANVDDNDDIDNYDDDNDDDDDDDDNDDEDDVDDNDDDDVDKVRAKVDNLSVDNDDNDVVNSDNVDVDNDNNNQG
The following text describes a protein:
Function:
Acts as a transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.
Subcellular Localization:
Nucleus.
Sequence:
MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLGAEEAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPPAGATSGPARSGADLERGAAGGCEDGFQQGASPLASPGGSPKGSPARSLARPGTPLPSPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNASSSTLLQGTGNGVPATHPHLLSGSSCSSPAFHLGPNTSQLCSLAPADYSACARSGLTLNRYSTSLAETYNRLTNQAGETFAPPRTPSYVGVSSSTSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPSPSSNAFATNQTHQGSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPSGTMTDRQMLPPVEGVHLLSSGGQQSFFDSRTLGSLTLSSSQVSAHMV
The following text describes a protein:
Function:
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor. Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).
Domain:
The PPIase activity is mainly due to the first PPIase FKBP-type domain (1-138 AA); The C-terminal region (AA 375-458) is required to prevent tubulin polymerization; The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400; The TPR repeats mediate mitochondrial localization.
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MKFSSCSIHGITKAEKIQIEAAKETQNRIKIFNELKEKYRNKTGSLEEQLKLNSELLTISSQDYQYWNERKEMIEELLKKEENENDKILSYELELTKNLLPKNSKSYVIWYHRKWSISKMEHPKFEIERELCAKMIGKDSRNFHCWGYYLWVLEQGKISQEEDLKFITDSINNNFSNYSAWHHRSVIFSSYNNLQLEKVIESEFTLLLNAFYIEPNDQSAWIYYRWLLGTGMKCYNELNKKEEWMNILKEQFNKIKELNEIEPNSKWVLFTMVELYQITKKIDSTIELLSNEEVKDFIKTLQRVDSMRSGYYKELEKDLLLIQI
The following text describes a protein:
Function:
May be involved in Golgi maintenance and protein secretion.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein. Cytoplasm.
Sequence:
MAQIEKKVGLLRKSSASKKPLKEKVVLMYDEIFTKEDPTKSNPRFWDELFLMKVNIEYLESKLESLDGEELMKLKDNINSLFQHCIHALRAEHQIRVVNSLQTLCALIRGVHQKNKPTSGFDIINMLMGFDKAELRMKNLMESLDLLLCGDGSESLKSLCLKLLLCLVTVTDNISQNTILEYVMINSIFEAILQILSNPLSRRQHGYDAVVLLALLVNYRKYESVNPYIVKLSIVDDENTLNGMGLVIARALFEYNRQYTDKEEENQTGFFSALTNMVGSMFIADADEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVAVPISPIPTTPTSPLGTTPPSSDVISPTELPMDADVQTSNLLITFLKYSSIVMQDTKDEHRLNSGKLCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNIPCRPLVCAVLDLMVEFIVTHMMKDFPMDLYTRCIQIVHKVLCYQKKCRVRLHYTWRELWLALINLLKFLMSNETVLLAKHNIFTLTLMVVNLFNMFITYGDTFLPTPSSYDELYYEIIRMHQIFDNLYSMVLRLSTNAGQWKEPASKVTHSLVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEVVRSNYDTLTLKLQDGLDQYERYSEQHKEAAFFKELARSISINVRKNVAFNTLSQEILLKEFSTIS
The following text describes a protein:
Function:
Involved in oxidative stress resistance.
Domain:
Deletion of the N- or the C-terminal 10 amino acids abolishes activity, while a region that includes amino acids 56 to 80 is dispensable for activity. Contains a predicted HTH motif, which may bind DNA.
Sequence:
MLSLSKPLQEFYRLDKCLSKHGTRFEFVNDKEIICSPDESNTHTFVILEGVVSLVRGDKVLIGIVQAPFIFGLADGVAKKEAQYKLIAESGCIGYRLSSSQTLAIIEQNQLWREAFCWIVWKSQVLELRDKQLIGNNSYDQIRATLMTMIEWDEELRSRIGVMNYIHQRTRVSRSVVAEVLAALRKGNYIEMNKGKLISINRLPSEY
The following text describes a protein:
Function:
Acts as a component of the trfA-tupA corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex (By similarity). Required for normal growth and for aggregation in early development. Required for a proper chemotactic response to cAMP.
Subcellular Localization:
Nucleus.
Sequence:
MNVQQTQQQQAMAAQQQSMVAQQQQQIAQQQSAIAQQQIAQQQQIAQQQQIAQQQQQHQQHQQHQQQHQQQQQHQQQHQQQQHIQQQQQPQQQQPQQQQSQQQQQQHQQQQQPQQQQPPQQQQQQPPQQQQQPQQQQQQQQQQQQQPQQQQQQQQQDQLSGVTGKIRDLNESIWIHLGGYAESIGEQDKALASYENALRHNPFSIKALTQIASLFRIKEQYSKAAEYFQRIVTIESKNGEVWGALGHCYLMMDDLQKAYTAYQQALYHLPNPKDPNLWYGIGILYDRYGSYDHAEEAFTAVLKMDNKFEKSTEIYFRLGVLYKHQGKYDQSLEYFQHLVKNPPLPLTTSDIWFQIGHVYELQKEYHKSKDAYEKVLKDNATHSKVLQQLGWLYHHNPLFTNQEYAINYLMRSIDSDSSDAQTWYLLGRCYMTQQKYKKAYDAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYTRAIRLNPFLSEVWYDLGTLYESCHQHTDSLDAYQRAAELDPHNKHIQSRLATLRAQVSGKPIGKDGYDLQNGEHGEHGGKSTPMIIEPNSPGTGAMESLGKGGQNNRNGNNNGNNSFVPELAEINSHLPEDMRNNSSLPSSNELNSSLIDRKTERGRGEDMHNSHHSQYSNSMSMNNMNNNNNNMNMNNNMNNNMNNMNNNNNNMNSMNNMNNNNNNINNNMSNNNNNNHNNHQMNQYNNNNNNSNINNNNNNHHNMNDNVNSKNNDVLDRRYKGILEREKTSPNGDGRDNRDNIRDNRDNRDSRDGRDNRDGRDSRDRIQEYTREYNNNNNNNNSISSINNNNNNNNNNYNNNNNNNNNNNNNNNNNGLRATSPLPSHNDRRSYERDNKERINNNNNNNNNMNNNMNNNMNNMNNNNNNSNISRFEHQNNRTSSPFENNSNNNNNNNNNNNNNINYNNIGQRALSPQSSQHKDRREIILDEESDINERSKTRSPSIVKEAEEKRETVIVDKERSPTPIITEKPDEKQVEKVTDKESSLVEKVDKENEKESPSSSSSSKEIEKETEKEKEKEKEKEKEVEKEVEKEIENDKEKEKEKEVEKDVEENKSVEKSSEKPVEKESTTTTTNDEDEEGELSEPTTTTKKDDSSKLPTDEKKLSSVSPTTTAVEQSRDETKELEMDTKEDSEKEKKSSTTTTAAASESVKPIDEEKKSPTTTTTTTTNTTTVEPTHKDKESSKNDDTTTTTTTTTTKSAKSPNSSPTRSDEVVEPHQDASQEEINKRKLEDDITSTPSKRLKPDSTPSSATTASTPSEQPESPLKKENPVGETLSPEIKDSKSSSSSSSSSSSSTNTGSSSTNSSAKNERDRDRERERERERDREREREREREREREREKNKQPTRAPIKPSSRKLER