lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cell cycle. Involved in formation of flagella, regulation of flagellar length, and formation of median bodies during interphase. Regulates flagellar length in all eight distal flagellar tips by promoting disassembly of the microtubules (By similarity). Disassembles microtubules at the distal flagellar tips in a length-dependent manner in order to maintain different equilibrium lengths of the four flagellar pairs (By similarity). Regulates interphase and mitotic microtubule dynamics (By similarity). Regulates microtubule disassembly dynamics of the dual mitotic spindles and the median body (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum basal body. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes and accumulates in a length-dependent manner to the distal regions of flagellar tips (By similarity). Amount at the distal flagellar tip increases during de novo assembly possibly as a consequence of its transport along the flagellum (By similarity). More of it is present in the caudal flagellar tips than in the longer anterior flagellar tips (By similarity). Amount decreases sharply immediately proximal to the flagellar tip indicating that it does not undergo directed retrograde transport on the axoneme, but likely diffuses from the flagella tip toward the base (By similarity). During diffusion, it may be recaptured by anterograde intraflagellar transport (IFT) trains to sequester it to the tip region (By similarity). Localizes to basal bodies, to microtubule (MT)-containing structures such as the median body and axonemes, and to the tips of all eight flagella in interphase. Localizes uniformly to the median body and unevenly at distinct regions of all eight flagella, primarily localizing to the distal flagellar tips, in interphase (By similarity). Localizes to the cytoplasmic axonemes in interphase (By similarity). Localizes to the ventral disk in interphase (By similarity). Localizes to the plus ends of interphase and mitotic microtubules (By similarity). Localizes to single spots on chromosomes during mitosis (By similarity). Localizes to the plus ends of microtubules and kinetochores in anaphase spindles (By similarity). Localizes to the growing flagellar tips of the posterolateral and ventral axonemes during mitotic telophase (By similarity). Also localizes to kinetochores during flagellar duplication (By similarity).
Sequence:
GSGKSFTMMHKDNGIYVLACFDILEYLRVYNGSQGNNSKFLVPVVSFFEIYGGKLFDLLNNRQRLQALEDGKGNVQITGLTEKQISSVDAMLNLIDSGLTLRAVGATGANADSSRSHAILQIALKYTKSGKEYSRISFIDLAGSERASDVQNSDRQTRMEGAEINKSLLALKECIRAMDKSNDSKSGAHIPFRGSKLTMVLRDSFIGNSQTVMIANISPNDKSCDNTLNTLRYADRVKELQHGKGGIIKFNVLKMGQNAADVILGTARDDENDVYKAGIVGVNAAPSQQARVPPASQAPITARQIQQNLPQPHYNPNYNPPNSKPAFEPRVETTDEDDMVRTHCDLVDSIYEQEDLIVRAHRRQVDSMMQLVKEEVALLHAIENDQVSIDDWLVKLSDILSRKEEAITTLKGNLSAFKQALQKEEELSHSIDLNKARKK
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MGEFEVDGEEKLIVAAKYLVKELRSGKSLTKNAKNVLGNLLLELSRVVIAEDTQDRDEEDEIGEIEERLNVVSEKIMTREVDESMIWDLGSDEGNLYLDAVNELRSLIDRLDGSEELSLRKAHDVLQIAMARLEDEFKHLLVENRLPFELEHSSFRSIEADHGVEEESMASFGAASTEDLILGSNNDSRRNSGDVVVDLVNPDVILDLKNIANTMIASGYDRECIQVCTMVRKDALDEFLYNHEVEKLSIEDVLRMDWATLNTNIKKWVRVMRDIVQVYLLSEKSLDNQIFGDLNEIGLTCFVDTVKAPMMQLLNFGEAVSLGPRQPEKLLRILEMYELASELLPEIDALFLDHPGSSVRTEYREVMRRLGDCARTTFLEFKSAIAADVSSHPFPGGAVHPLTNYVMNYLMALTDFKHTLDSLLMEHDDAEDLTIPPSPDIINPVMVEEESTYENSSSPEKFLAMTRHFYSITSVLEANLQEKSKLYKDVSLQHIFLLNNIHYMTRKVLKSELRHIFGDKWNRKHTWKFQQQATEYERATWLPVLSFLKDDGSGSGPGSGSGSGSKNLRPRERFQGFNTAFEEVYKAQTGWLISDEGLREDVRTKASMWVIQAYWTFYSRHKNSVSERYIKYTTDDIERLLLDLFAGSSKSLNNSYRR
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSSEKGEGTDPKLRNGPVVERECTDIFCLLLFIVFTFGMFYISGYAFKNGDPHRIAQPYDPDHRACGVDEDVADYPYIYFANPTNPKYLYVTTCVSECPQEESEPAPTARHTKISHLEEAKTNSKLPSELKCQPNSIVKSCKQNMLSTNPEEVVVIYNTELFMKTVCLPTTKQYYETVKDKIDVETMEKVSNDMITTKWLIFGSIGISLVLGFIFLFLIETLAGCVIWTLLFLLFSVLIAGGVYTTGYYYALTDPSKLPASAQAEIDAQTLQEQAQANNVNPKNYLYIGITLFSLAGLILLVVCCMYSRIRLAIAILETACDYVQANFSVVILPFVTFFIMLLYFIYWFVVALYLYSSGEVTNKPKQLPFGQFSFTQNQKIFANLHLFGLLWNSSFIIASVEFIIAGSVCIWYFQQGPRAQEGGPIPLPTAIGRFFRYHLGTVAFGSLILAIIEFIRIWLAFLYKQQEELIKKNKFFEYLFKCLMCCMWCFEKCVQYINKNAYVVSNMTGKGFFHSAKEAVFLIARNPLRFATVGGFGEIFIALGRGFIALLTGLFCYFIITRTEKFKYNVTYPEAPALLCGAIGLVVGSLFMSIYGVACDAILIVFVMDEEMEKQNGKGVALCCPPKLEKFLEDQ
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MGDSSREDASNTLRVLVATDCHLGYMEKDEVRRHDSFQAFEEICSIADQKQVDFLLLGGDLFHENKPSRSTLVKTIEILRRYTLNDRPVQFEVVSDQTVNFANIFGHVNYEDPHFNVGLPVFSIHGNHDDPAGVDNLSAVDILSACNLVNYFGKMVLGGSGVGQITLYPILIRKGSTLVALYGLGNIRDERLNRMFQTPHAVQWMQPEAQEGCQVSDWFNILVLHQNRVKTNPKNAISEHFLPRFLDFIVWGHEHECLVDPQEVAGMGFHITQPGSSIATSLIDGESKPKHVLLLEIKGNQYRPTKIPLKSVRPFEYTEIVLKDEADIDPNDQTSILEHLDKVVRNLIDKASGKFVNGSELKLPLVRIKVDYSGFMTINPQRFGQKYVGKVANPQDILIFTKASRKGRSEAKIDDSERLRPEELNQQNIEALVAENNLKMEILPVNDLDVALHNFVNKDDKMAFYSCVQYNLEETRSKIARDSDPLKFEEEDLILKVGECLEERVKERSVHSKETPQFMSSARSLENIRSKGTAETGSAVSFSDDEDPTQLSGSKSATRGRKGSSATFKSSHDASEQGKGKSSTRGRGRGRGRGRSSSTLKQMTLDSSLGFRHSERSASVAATAAVRNLADDEDNVESSSSDEAGKYGINEVDDSSENDENLQGKGRKRAAPRGRGRGATTSSKRGRKSDSTSIQRMLMNKDDDDDDEDDMSKRLNKPQPRVTRNYGALRR
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope.
Sequence:
MKRSEELVTKNYNQEDISILRCWKCRKCVASSDCFMKYLENQVVKDRHDSADDQNICHVWHMNIEVLPEWINCLIQKAQWTVGKLNCPFCGARLGGFNFVNTPKCSCGQLAAVHLSKSRTDYQPTRAGQLMRPSLKYLSHPRVQSGCDKETLLTGGASKNRNHSLLNMAQNNNGPGRLTEALCLEVRSMCFEMKNEKLLFKGSDPKYQLFVPQLVTGRCTTRAFHRKSHSLDLNITEKLSLLPTFYEIHSKTTAYPRLNETQPIDLSGLPLEASKNSCSFQTSSSFDPNMLLQRFSVAPHETQTQRGGEFQCGLEASALYSDHASSSNLTFLMDLPSADRSMLEASDQEEHLSHLDFVGSGSFSLGAINQRLNKRERSKFKNLRRKQRRHERWLQKQGKYPGMGLLDHMTLNNEMSTDDDNECIEEKESYICAVCLDVYFNPYMCYPCHHIFCEPCLRTLAKDNPASTPCPLCRTIISRVFFQTELNNATKTFFTKEYLKIKQSFQKSSCAKWPLPSCRKALHLFGGFHRHAAPVTRRQFPHGAHRMDYLHFEDDSRGWWFDMDMVIIYIYSVNWVIGFIVFCFLCYFFFPF
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane; Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGASAEFLVGVLGNITGVCLFVAPATTFYRIFKKKATDSFSAIPYLCTLLNCVLWLLYGMPFVTKNGVLIMTINGIGAILEMCYLSIFMKYAAKPGKIHTAKVGGTLGVFFIVVVLVVVFATHHLHARHTIVGILCVIITIVMYAAPLSVMRVVIKTKSVEYMPLPLSVMVLLNSAAWSAYALLKKDIYIMIPNFFGVVLGIGQLILYWWYYGAPKPTLQEELEMGQKSAQQGSNELPPGALDVSNPSDVHSSNMESVSLKDSSSVETKISGSPTRGSTLPAYSTIAFSSHNLRS
The following text describes a protein:
Function:
Hydrolyzes chitosan and chitooligosaccharides with retention of anomeric configuration. Has no activity against beta-D-galactoside, beta-D-glucuronide, beta-D-mannoside, chitin, glycol chitosan, cellulose, N,N'-diacetylchitibiose and pNP-GlcNAc.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MLANAIAALLLGSGIASAAGHGSPLTSKAGHRAVIPDWDLKSSSDVSKDLGGLSKPGVDTSSWYHAGTSRCTIMGCLINAGVYNDEELWYSDNLNHVNWGQFSVPWVYRHEFALSPAKGKHFLLQTNGITSKADLFFNGKQIADKEYQSGAYAGRTYDITNLAAKKNALLVQVYPTDYLYDFALGYVDWNPYPSDNGSGIWRDITIKETGSVSMGPVSVLVDIDVPVEKNPARVTVRAEAQNLESHAVEFNAAAVISGNSCSGEALKQTIKLAPGEKKLVQFTQTIKTPSIWWPKQWGDQPLYTAEVTFSVKGAVSDTAQTKFGVRKVTSFVNQFNDTQYSVNGHPFQVIGGGYGADMFLRWDSERFTRIVEYMLDMHQNTIRLEGKMEHPELYEICDEYGLMVMPGWECCDKWEAWAYNDELAIFPPPVWDANDYETANYSMIHEAAMMQPHPSVLTFLVGSDFWPNDEAVVLYANALKNAGWQTPIIASASKRGFPALLGPGGMKMDGPYDWVPPNYWYDVEPSEDRLGAAFGFGSELGAGVGTPELSSLRRFLNQSDLDDLWKNPNKNLFHMSTNASSFYNRKIYNQGLWKRYGAPTSLDDYLLKAQMMDYEATRAQYEGFGALWTASRPATGVIYWMLNNAWPSLHWNQFDYYLHPAGSYFGTKVGSRIEHVAYNYQKKEIWVINHSLYQTGSRNIKVELIDMNGKQIAKKLVQVRTKANSGFKAMDISSDINKLSSVAFLRLVLSDEKGSVLSRNVYWVTKTIDELNWDESTWYYTPVSKFVDYTPLNTLATAQVSVTTSGGKHLPGIPGSQTRTVTLENKSSVPAVFIRLTLVDSKGNDVNPVSWSDNYVTLWPHEKLQLEVGGWDGSGDKIQISGKNIKATTVKL
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
Sequence:
MRSKFMKLLFLLVGFVLSSINPVADAIPLSNSVLYKDSDPIVQMNIADFKSTIVATSNAWLVEFYSSWCGHCIDFAPAFIQLANDVKGWEKVIKVGAVDCAKEENIPLCRDFEIMGYPTLKFFPAFTDASHLGIARTGGKKIDAIRNSMIDFIEQQFAEKKAPPHWPVLGSLQNETLEDLWNHYNNNEIILLFETIDNSKYWSREAIMDAHQYAPHYPPIRRVNATHKDLVTKYNVQSLPAFVFLERTGKSELYQIQPDRDYMKKIMRKFFDSENEEGSLAIANIPKPVHTQEPHAIHTNVKAAKDQVYMADLEGALLYAFGHEVSVHKLIVGKELAALKQLINVLDQYFPGRPEMKETIHSIRRNLEGYKKQIRGEEFSKLWRDALNGRETNQEWVGCRGSRPNLRGYPCSLWTTFHTLTVNYALKKSDDTSNEPNLILQAMKGFIKYFFGCAHCSNHFVDMAEDEVDPIESVKSPRQAVLWLWAAHNKVNRRIASDASEDPKAPKIQFPAPNNCPDCRPNGVEREEAVYDYLIKLYHPDHVSSVGLLIERNPAHSGSSRVQSLPLGTLSFTGYDISLCAAIYLVSSLILMLVLCRILVKRRRYVRKQVYDVCGKLM
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGRLFQLQEYCLRAMGHKDDMDSTDSTALSLKHISSLIFVISAQYPLISYVAYNRNDMEKVTACLSVVFTNMLTVIKISTFLANRKDFWEMIHRFRKMHEQSASHIPRYREGLDYVAEANKLASFLGRAYCVSCGLTGLYFMLGPIVKIGVCRWHGTTCDKELPMPMKFPFNDLESPGYEVCFLYTVLVTVVVVAYASAVDGLFISFAINLRAHFQTLQRQIENWEFPSSEPDTQIRLKSIVEYHVLLLSLSRKLRSIYTPTVMGQFVITSLQVGVIIYQLVTNMDSVMDLLLYASFFGSIMLQLFIYCYGGEIIKAESLQVDTAVRLSNWHLASPKTRTSLSLIILQSQKEVLIRAGFFVASLANFVGICRTALSLITLIKSIE
The following text describes a protein:
Function:
Putative transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MEYLKLCFYLFFFYFVMEQIQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQQQQQQQQQQQQQQQQQQQQQQQNPKMNNQPNETRLPSPPLLNSTVPKNELNINHHHQHNYKINSAPLKASQHANEYDHNEESLNSSNNNNNNNFNNSRPTFSSCSGNSNNTTTTTTTTTTTNPINGSVNSNVTTTSINTIHQKFITQLKQRLGKGIDYNNYINKLKNINNINNISKLINLSSQPDAIGKNNNLISNTGPVAEMYDDEEFDEFDEEEDDDISAQKLVGILSRESSSSNLSSIAPSPLLQQPNCLPSPFINGTPLLSNHSNNNNNNNNNHHHHHHHHHQKRLSIGSMDSTNHLTPLPLLHKHTNNNNNINNNNNHNHNNILGSPNQLNRSQDFTSKNNNINNNNNNNNKIINEENCNKGSPNQNSSENNSEEENEYHGGEEGNVYSVYDLNSPYFNERKQRALSNNKSQQPPQHVPTPCTYNDCCICAYGPPPSFFTSAPTWADICYIALYCLTLSRPEVKYYHIKKDICTFIDCHYETICMRKRTSIWRQTVNMTLSHPQYFEMFQQESALENGRKGYYGLKQIHDPYEHTALNKRSRRKRRHEQKMIQEELKKNGFTNLLLNSPSIENNDQHHNGYIQSYNNNSNHNNNNNNNNNNNNNNSNNNNNNNNNNSNNNNNNNINNNNINNNNNNNILTSPIQHHPHSHQQQHHQQQLQHQQHQQQQLLHQQHQQLLHQQHQQQLQIQYQQQQTHNNNLNQTQQLYYNHHHHQQQQQQQQQQQQHNNNNNNNNSNHNSVLTSPPLSQFPKTPLQLSQTPQHSLSALSSPFLKTLTIEDEDDSYNGQVHKKLRSAKLTSVNSINSNSGMSLPMISSPSPNLSHMQKNRPNFDDILNSSLSSSNTTNSATTSSSNSILSNSLSNISNSSGGSGGVCISEDYESNIQRRKSLNNIVLNKTNKNILPKLDDECDDEDDFHFTENEREVPVSNLKSSSFIINKNNIINQQNYNENNNNNNNNNNNNYNINNINNNNNNNFDDADDENEFENKDNINNNNNNNNNNNNNNNNNKNDKNESEFESKEKLNSPFGSSIPNIVNNEQLSPYSQQSLSSSSSENPSPQWSTNGPSQTSSSKLSNSTSTLINNNNNSMSIMSINSSGNSINNTTTYNNNNNFINNNSNNNNNMEIDDDDEDGIDGIEGEDDSKKRMRKTTRPDEKIYLEIYYQHFYENNGKHSKDELITLSNNLNWKVNRIQRWLDNRRTKDKLKNLRVSQERTISFGASSTSSTQTSTNSPSSQLSPLVPNMNNNDQQSISTPSLILSQINNNQNNNQNNNNNNNTNNADVTLISNNNVPNTPIMANTQSNINSLLN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAGDERWNYGNMDMYLPQNPPSSGSISQNYNQQTEPLPHRTDGEPPVTQNGQTSHEDSAFYLLKDMPGIPRPGGPHHVSPGAQAAVDITGSVNLIQHHGLEHSFHKFCGKKVKEPLSNFLPNLPGFIDTPGLQDGSSLRSLIEKPPIVGKELYQLSGPQLQGFRLHPGPIPEQYRLLHQQPPAKKKHKNKKHKREHSKTSEGMSVQDSSQSHTDMGASSTTSGEKSEKKTKKQKKHEDSEKKEKKKKKDKKKKKTGST
The following text describes a protein:
Function:
Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGNLLLFILYIYILFQPHQKKPVDMIFTHLMLVNVLSIVFKLIPDVMKFFAVRLLFQDVACKAVLYAYSVTRGLSLCTILLLSVFQAITVSSNHSKWAWLKSKLESCIFPSLLFIWIINSFLYLPMVENIKGRINFTVVASRYSQIYCQSSQVRYHSTLSLVTALIIRDILFVFLMMWSSLYMVSLLFRHNRRTQHVHSFSVSLHASSEKRATHSILLLVGFFMFFYWSNTFVTFYSLYQPKSSPVLDLISGVLSSGYPTVCPYVLLNNRKLISKFISSFSDFKCTFFTRGCHG
The following text describes a protein:
Function:
Plays a role in promoting sleep by enhancing metabotropic transmission of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in GABAergic neurons upstream of a wake-inducing dopaminergic pathway.
Subcellular Localization:
Nucleus envelope. Presynapse. Cell projection, axon. Perikaryon. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Detected primarily at presynaptic sites on axons, and to a lesser degree in soma and dendrites. Not detected at post-synaptic sites.
Sequence:
MKMLADTEREEALNLQIEFEWVLRQEVHAILKQLRSILVECAHRFPVPLYENEGKKTEKFILTVSPDQLKAVLTLTGDAITQADISFKLCKAPSQTQRTSITHDSPWKLQQVQDAANHLQTAINHIDDVDDSYHFKTSDEVLHVIGNILDALQRGRNSLLVPKKKPIDELIKGRNMKSLVPNLPEDLAVSFYLQSHKLIIAVYQLLNNQGTMRFDSRQAEASVQWLNDVLLLLMNGQKLCQQLKDKISVFSVYKDFTVGSRSPSALSY
The following text describes a protein:
Function:
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.
Sequence:
MSASNLVQVNSPEHFRELLSADLNRVSCLNFWAPWAEPCVAFNNAVEQEAAQFPSVLFLNIEAEQLADISESFDIEAVPSFLVLRGHTLLARHSGADASLLRSLLTQHASPSAPLSTSSAQPQAPAAAQRPRTEAEIVARCHELMNKHKVVLFMKGNPTAPKCGFSRQTVGLLREQGVEFAWFDIFSDEDVRQGLKKVNDWPTFPQIIVNGELVGGLDILREMIENGEWQELMDSIEEGKAE
The following text describes a protein:
Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Subcellular Localization:
Cytoplasm.
Sequence:
MIEIDGSYGEGGGQVVRTAVALSAVTGKDVKVTNIRKNRPNPGLKQQHLKALETAARICEARVSGLFPGSSELFFSPVEIKGGKYEVDIGTAGSITLLLQSLMPALPFAKEKVKLTIKGGTDVAWSPTIDYLQHVTLRALEQLGYAGIVTLKKRGYYPRGGGEVSAVFEPCKLRSFHFRRVKENRRTGEARREEETRNEGRNQNQRIEIQGISHASNLPAHVPARQAEAAESLLLEAGYGSRTKIQSFELLSTGSGITLWSGYCGGSALGKKGLPAEKVGRRAAEEIILELSSKAPVDVHLADQLIPYMALAGNSSYTVRELTLHAATNIWVTEQFLDVKFRIEEKEGLFEVSVD
The following text describes a protein:
Function:
Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility.
Subcellular Localization:
Cytoplasm, cytosol. Mitochondrion matrix. Note=Hypoxic conditions promote mitochondrial targeting. Targeted to the mitochondrion following phosphorylation by MAPK1/ERK2, cis-trans isomerization by PIN1, and binding to mitochondrial circRNA mcPGK1.
Sequence:
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Domain:
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence:
MDPNCSCASDGSCSCAGACKCKQCKCTSCKKSCCSCCPVGCAKCSQGCICKEASDKCSCCA
The following text describes a protein:
Function:
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Sequence:
MAESEKEAALPPKEEFSDWYNELLWMAEIMDVRYPVKGLYVWYPFGFAIRRSTYNIIREILDNSGHQETLFPLLIPENEFMKEAEHIKGFENEVYWVTHGGKDSLDIPLALRPTSETAIYPMYKMWVRSHADFPIKLYQIVNTFRYETKHTRPLIRLREITSFKEAHTVHATWEDAEAQVKEAVELYTEIYRRLAVPVLRSRRPDWDKFPGADYTDAIDAMMPDGRTLQIGTVHHLGDNFAKTFDIKYEAPDGEQRYAHQTCYGISERSIAATISIHGDDKGLVLPPEIAPVQVVIIPIIFKKGAEEVLAACRDVQERLKKTGVKVEIDASDLRPGAKYYRWEMKGVPLRLEIGPRDLENNVAVSVRRDTGEKEQIPLPEIETGVLQKFEAIQNSLYEKAKVGLESRIFDCTELEEVKEKIQKGVATIPWCGKKECGLAMEDRIGAGILGIPLTPRGKGKEKCPVCGAETETRVYVARTY
The following text describes a protein:
Function:
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.
Subcellular Localization:
Nucleus.
Sequence:
MDATFPKEEEDKGLDQELPVQINENAKVTGDFHQELLVPIEEEENVTTVTDNRLELPEQMEEDETKRLSQENHLEVEMKEGGHERKIGESDQVLPGQLKGKEEPRLLVNNERLMLKQKEKDGTLRETEQELSVVEKEEEEEEMEVSLAKPEANPIMTLNKATPPYSETRPEKTRDEQTPVSLVAMTVCMVENSEDEEETEDSDSDSSSSSSSSSSSSSSPSRPLFEDDDDEGFSQPVPVKSKDEICFEELPAVDELSVTLPAGAELQPVGTISSIIQQLVIVQSMKDTPPLNDDSIIFKSDRLAVGKVFEVFGPVSSPLYILRFNSNEEINSKGLTEGMTVYYAPTIKEYTEYVLPQQLKLMKGSDASWKNDQEPPEEVLDYSDDEKEKEAKRKAKNARKPKDYGNTESSADGFRNSYHRRRKDSRGFPPRHAGPPFSHQDQKSKQPSYGHPPAGQQTVPPVHLPPPCPYPLPPPLSQPYHFHPPGGEAPSHFAPPSFPLYPPGVPPLTAPPPSYFNPAFSSPPWPPNFYDFLLSPPPPPPPPPPPPPSQ
The following text describes a protein:
Function:
Required for maturation of 30S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKKIEEKIGGVIESLGYLLYDVSLVKENEQHVLRVSLKNPNGAVSLDICQQVSEIISPLLDVCDFIQDAYILEVSSMGLERTLKTPKHFKLSLGEKVEVKLTNKESFQAVLKDANDLSADFELEDHAIKSVEYKDLKKVKTLFEW
The following text describes a protein:
Function:
Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCSLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIHFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIGIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIYLSENRLENLDILYFLLRVPHLRILILNQNRLSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRRLRLNSNRLTVLSHNDLPANLEILDISRNQLLAPDPDVFVSLSVLDITHNKFICECELSTFIKWLNHTNVTIAGPPADIYCVYPDSLSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDENRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS
The following text describes a protein:
Function:
Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation. Binds phosphatidylinositol 4-phosphate.
Subcellular Localization:
Cytoplasm. Nucleus. Forespore membrane; Peripheral membrane protein. Note=The sporulation-specific septin complex associates to the forespore membrane and forms partial or complete ring-like structures that curl around each haploid nucleus.
Sequence:
MNKGPRHRPKFLSKKGKKLRIMVAGSSYTSYQACINSLCSKQILEAETEIDPLKAHIDRILEIREFNADILEDEFHVDLTVIEVNGFGDKIDNSASFEVVTHYLESQFDQALIEESKIKRNSKFTDTRVDALLYFIAPRGHCLSEFDLEAMKRFSKRVNVIPVIGNSNAFTEEELKNFKDVIMKDLKQCNIKVFDFPWDPEEDEDEVIEDNKRLWESVPFAVSGGVSEEDEEGYQRIVKKFQWGTFVIDDPAHSDFLNLKTVLFISHLDILKSITKQTYYENYRTEKLSNDSPSNTSLSLQKQNSIVANEDKRSVNGSERTETRSSIDQSEMRTNVSDSTKSEELKKINSIKVDNTSSLKCDSYGNTKTKTNQLNCEQIGLEVISPKEFPHRTTSSRNSLPNNTTKELEMKKMDDLSHERYENLPFYR