lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May play an important role in neural development; the dorsomedial roof of the third ventricle.
Subcellular Localization:
Nucleus. Note=Subnuclear distribution.
Sequence:
MVTLITEKLQNQSLDDLTCKTYNINLYSSEKLNKSGSLFSFEINEDSPWKALNGGCPIQTDARNSAYPFPVCPFSTGPASNGALQWQQEPSSTSMVSGWISELNLNENSGQPLAPPTKRHCRSLSEPDELARCRSPWKPGNSKVWTPVSKRRCNSGGSATLQRCNSHGSATLQRSTSISLPQNILSLNNVFTVTSFNTSPVPRPSSASSGFVDSSEGSTSSSTRWNSGGPCDFNPRRRLSLSQEHITETGNLLPSANSTPTSTPELSRRQGLLRCRSQPCVLNEKKSRLKRRREEDVRWNRPSLDFFKMTRTLKNSKSLCSLDYEDDDDDTQMKTIVSSPCDSNDLMNIITPGSSPMKEQLDEVRHHGSCQGSFKTRDYKKAAAVCESDEDTSDCESTEEGIFPLDCGDLDLEQIENN
The following text describes a protein:
Function:
Has a role in the perception of gravity.
Miscellaneous:
MISCELLANEOUS: Named after Alan Bartlett Shepard, Jr. who was the second person and the first American in space and the fifth person to walk on the moon.
Sequence:
MHPRYSPAPPPQQQQQMGGPPHQQQGGGGGGGGSMRGPSNAQQLPPQIPRSQNYSNGSSSSAAAAPPTSRSAFPGAPLTASAVALKGALPQRPPAMTSPAAAAAGAALAAGAPYRGAASWTPQGYAPAAAAAAAAVAQQAAYRYTAPLPQPAYAAYTPHTATTPATTTYGQRVPTAASPSNTNSSSSSNTGSQSGTLSTSLSNTTNTNTNMGPNGTVQNQNQQGGEQLSKTNLYIRGLQQGTTDKDLVNMCAQYGTIISTKAILDKTTNKCKGYGFVDFEQPAFAECAVKGLQGKGVQAQMAKQQEQDPTNLYIANLPPHFKETDLEAMLSKYGQVVSTRILRDQQMNSKGVGFARMESREKCEQIIQMFNGNTIPGAKDPLLVKFADGGPKKKNLFKTPDPNARAWRDVSAEGIPVAYDPTMQQNGVSVNVGTPIGVPYSRFSAPQVGGYPVAGSQWIPGYMMTQPITQVDDQTSYSPQYMQMAAAPQLGVTSYKPEAVNQVQPRGISMMVSGDTGVPYGTMMPQLATLQIGNSYISPTYPYYAPPPTIIPTMPMTDSEQASTAASPDEAYTQYPHQAAPK
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MTSKSKRTLTLPTYVAHQTLEASSAHSEKRTSSKQTVEWVPAPAAGHGEPCSSGLEYLSEVDQVLLHPQRVLLEAFDGLPCTQKFQVKTARGQMMYCAVQRTDHQSQSFRGHRRAFQMEIYDRGARESIRLRQPFVCSLCFPWGAQEMEVQAPPGVVVGFVRELLHPWGPRYVIKDSRGEPALRIRGPGYITCCSPPDFTVFDPSWKTRLGAITGQYFGSIQGDFGDVVAVKFPRDLDEKLKALLLGASFLIEITFFTLARHS
The following text describes a protein:
Function:
Predominant proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Has proteasome-inhibitory activity and delays the degradation of ubiquitinated proteins to provide a time window allowing gradual deubiquitination of the substrate. Stabilizes the association of HUL5 with proteasomes and works in opposition to polyubiquitin elongation activity of HUL5.
Miscellaneous:
MISCELLANEOUS: Present with 6770 molecules/cell in log phase SD medium.
Domain:
The N-terminal ubiquitin-like domain is required for proteasome association and UBP6 activation at the proteasome.
Sequence:
MSGETFEFNIRHSGKVYPITLSTDATSADLKSKAEELTQVPSARQKYMVKGGLSGEESIKIYPLIKPGSTVMLLGTPDANLISKPAKKNNFIEDLAPEQQVQQFAQLPVGFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENLQNKSFKSVLPIVLLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLFHSMSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQCHISGTTNFMRNGLLEGLNEKIEKRSDLTGANSIYSVEKKISRLPKFLTVQYVRFFWKRSTNKKSKILRKVVFPFQLDVADMLTPEYAAEKVKVRDELRKVEKEKNEKEREIKRRKFDPSSSENVMTPREQYETQVALNESEKDQWLEEYKKHFPPNLEKGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKIESLAGGGESDSALILMYKGFGL
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MSGWDEGNVFYSDQDLVDQNAVDNGVANRLVVQGKFKEFIRSYGELNGYFPYRASLLQNSSFLPVNLDDLDNFDMDMGDLIRKNPAEYMPMFEAAAADVAVGLKAKVAGDRGDMEEPTSGDVQVLLTSKQNPMSIRALTADSISKLVKITGIIIAASRTKAKATSVTLLCKNCKSTKVVPCRPGLGGAIMPRTCDHPTQPGEEPCPLDPFVVAPDKSKYIDQQTLKLQENPEDVPTGEMPRNMLLAVDRTLVQKIVPGTRVTVLGIYSIYQAGGSSGPQKGAVAVRQPYLRVLGLEQAIDGKSRGALDFDDAQEQKFKEFARSPDVYAKICNMIAPSIFGHSDVKKAVACLLFGGSRKFLPDGVRLRGDINVLLLGDPSTAKSQFLKFAEKTAPIAVYTSGKGSSAAGLTASVIRDSSSREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTAVLAAANPPSGRYDDLKTAQENIELQTTILSRFDLIFIVKDTRDHTRDMEIARHIVNVHATATSVAKDADGGADKENWLRRYIEYARHSSNPRLSESAANALQTKYVQIRKDMRQRQNDRNGEGSPIPITVRQLEAIIRISESIARMQLSPEASEEHVAEAIRLFTVSTLDAAKSGVAAHITVTPEMRTEIQQVEAQVKRRMGIGSRMSTRNLIEVLGRMGMSENTVRRALIVMEARGEVELMRERRVIQRNA
The following text describes a protein:
Function:
E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression. Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Also modifies PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity.
Subcellular Localization:
Nucleus. Cytoplasm. Note=TLR4 signaling pathway promotes nuclear translocation.
Sequence:
MSTSLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKLDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLEDTCKTIEECCRKQKQDLCEKFDHLYSILEERKTEMTQAITRTQEEKLEHVRTLIRKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKITEASKAFQMEKIEQGYEIMNNFTVNLNREEKIIREIDFSREEEDEDDEGEVDEEGEGEDAVEVEEAENVQVASSGEEETLEKAAEPSELAAEIQAASGPLLASSPDSVSSLPPAADVLVTQGEVVPTDSQQTTQSETSGPSAAETADPLFYPSWYKGQSRKMISNPPHTPGGEGLSQIGPSAAEDSSVQSAEVAEAAANEQAAVSGKESSSTAATSQIGFEASSPQGQAAALGSGGGADSEPARHVFSFSWLNSLNE
The following text describes a protein:
Function:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.
Subcellular Localization:
Nucleus.
Sequence:
MGVHSLWKIVGPTARPVRLEALSKKKLAIDASIWIYQFLKAMRDKDGNSLPSSHIIGFFRRICKLLYFGILPIFVFDGGVPALKKQTINNRKQRREKNSESRQETAQKLLAIQLQREAENALNRSKKPSNNTTNGDDDDVIYFEDLPINKPERESSTPSSIVYRKNDEYHLPDLKEFKVSKFDERIMPEEDLTEFYEDFDHVDGININEIDPKSKEFEALPIATQYMILSHLRLKSRLRMGYRKEQLEELFPNSMDFSKFQIQQVQRRNFYTQKLMDVTGMGADATISKRLAGDKDRKYALVKNEDGWTLALEGNSEDNPIQVDSDEAEDITREVNSYKEDLRQDKKDEESDSDFEDVPLEEIPETEEDKDYQRALIKSIYEQYNTQENMQAPTSTINGVDDDELRKAVEKSKIDYFELQAKETQQLEEEKFDFGSSMLFSTNAVKEEALQNSEEISNLTEHAHTQVNTVHPSEQDKIINSDTKKELPNSIGQSFLFNADPHRTGKIELRTKEETIFEPEESDFEEAKTNNDQSISHIEKAKKQEPTKDQQKLPDWFQSEVNKTLNPHNVKFVNYNDYQIRNQKNQEEKDAGLVPWYEAKEILEQEQSDEEEQEQEQEKPDNDSDEIEEISKEQVNISISEEKESVPPSSVEDIRKPAVMDYQFEEEDEEELVQQLQKEELDHESLKHQIKASHAIPLTSLETRITDEQLLQEKFQKAKRDSDEVTETMINDVQELLKRFGIPYITAPMEAEAQCAELYKIGLVDGIVTDDSDCFLFGGDKIYKNMFDQKQYVEFYLQDDLFNKMALTQHKLIELALLLGSDYTEGIKGIGPVQAMEILAEFGNLEKFKEWFDKHTKSVADKTELTKLQKSLLDRIKKGKLYLPDSFPDKVVEQAYMSPEVDSDKTEFQWGVPDLDQIRSFLMYNLLWTQTEVDEVMVPLVQDMNKKKLEGRQSTISEFFPQEYIQSRKELNLGKRLKTAANKLKKQKHL
The following text describes a protein:
Function:
Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
Subcellular Localization:
Cytoplasm. Vacuole. Note=Localizes to glycogen granules (glycosomes) in the cytoplasm. Localizes to the vacuole during nitrogen starvation-induced glycophagy (autophagy of glycosomes).
Sequence:
MSLPNAFVTLLTTSSYLPGALVLLHALHDLHPAPRDFQIVALVTPETVDAATIGELRRAGYDLVIGVEPIGSGKAGQVGLELMGRPDLNFALTKLHLFRLAPFFSTLIYLDADILPLRPISHLFTSTAPHVFSACPDTGWPDCFNSGFMVIRPRESDWDGLKGMLKDGEGEDGLYREAGNGSFDGADQGLLNEWFSEDGGGGDWNRLSFTYNVTPSAAYTWAPAYKRFGHKISNVHFIGPNKPWTSLPGRPAGVSNVKGKENSYDYLSLIDRWFAVYDKHVRPASALDPDISRRFAVPQTIAAWDSHANQARAAATVLPEDKLDLSELKAATERGVNAFKPGQYTSLPLEGRVDLIMPKPKAIPRAPISQLVASSTIAPSVSPSALTPPPADAAPAPAPAPVPTQTEQKTAQPSVWDAQRSSPPASAPPEMSVPHAYYHNAWEAPLSQQSSYYAHPESHRPATEHKEPEYPTLPKEVTGDSWYARFATSTPDKRAISAVFPWEEKSYGPGYGHGSRPKPERVFPKGEEPLPSLVQQLIHPLQPPSISIQNPTPPHPAHSQHQSHATGMGMAGQAPKSPSPPPRHVSMVEAMASYKNVWDDIPQIGRYVDIMSGKTGGKSVRGVSTRGHGHGHGHIQGHGQGQKQPQAQTHERNTSLHSLQSVPGTPRTQYSTFGKSPRLTNARNLERRESFEQPEDSADGDDENSTSASEEEGGKSREGNSSKPYKGNKKYKDRWAQTDRVKTVDETVQTQTHAGEEAAAGGLKMWGLPHASAHGRKSSKEIPFPIGSGNGRAGGGGQREAQTQHQSTYYEYQQQHPHSQQSRQGSMASPKPELNVRLPDYSFDFKGATSHAQGLAQAQAQAHGQPQGQGANPNLNAQHRHRPSGSFSTIYGGRGRVWDPNTDVEVRRRDSQEVLARFMQGSLGRG
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Miscellaneous:
MISCELLANEOUS: The N-terminus of this protein overlaps with a tRNA(Leu) encoded in another frame on the same strand.
Subcellular Localization:
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Domain:
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Sequence:
MAELADAPDLGSGARKGVRVRLPPPAPHKNGGKNESRGSGQGSLFKALTVEIQGDSVKEKIDEMYKQLQKTVQIQGFRKGKAPLWIVRAKYKDYVEEEVGKKIADETLQKALEEANLKPVADVFLEKVEVDEKEGKVKYVVSFEVAPEFELKDVENLEVEVPKIEFKEDYVKEELERLREANAVWEPKDENEPAQEGDMLVVEYEVEEIGGEGEKVKQETSVILGQGMLRPEVEEALKGKKVGEEVELKELPLYDQEGKEVGKVNIKIKIKEIKKKVLPELNDEFAKELGYASLKDLEEKIREDIKQKLEKLKEQVIEERVADKLVEIHDIPVPQTLLRRELSFLVDRRLRELQALGIDTRYVDIKKIVEEVQPIAEANIKLRFILDKYAQEKGIEPTGEDIEAQYKELAEQYGTTVDEIKKYFKENNLEQVVYEDARRKKALKEIISKVKIKEVEQKQEEEKKEEKEEVKNESQGNT
The following text describes a protein:
Function:
Enhances viral infectivity and persistence, and facilitates proliferation of HTLV-1-infected lymphocytes. Mechanistically, inhibits Tax-mediated viral replication and NF-kappa-B activation. Plays a role in allowing infected T-cells to escape the cytotoxic T-lymphocyte response by maintaining low levels of viral protein production. Also inhibits host EP300 histone acetyltransferase (HAT) activity, reducing levels of acetylated histone H3 at 'Lys-18' (H3K18ac) in infected cells. Contributes to the accumulation of chromosomal abnormalities by inhibiting double-stranded DNA breaks (DSB) repair through the NHEJ pathway. Participates in the modulation of host immune response at multiple levels contributing to abnormal interferon signaling and viral pathogenesis.
Miscellaneous:
MISCELLANEOUS: Expressed from antisense transcripts. While mRNA expression levels of HBZ-SI were similar to those of HBZ, HBZ-SI seems slightly more expressed at the protein level ex vivo.
Subcellular Localization:
Host nucleus.
Domain:
Contains three nuclear localization signals NLS-1 and NLS-2, corresponding to two regions rich in basic amino acids, and NLS-3 corresponding to its DNA-binding domain.
Sequence:
MVNFVSVGLFRCLPVPCPEDLLVEELVDGLLSLEEELKDKEEEETVLDGLLSLEEESRGRLRRGPPGGKAPPRGETHRDRQRRAEEKRKRKKEREKEEEKQIAEYLKRKEEEKARRRKRAEEKAADFARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELGVDGYTRQLEGEVESLEAERRRLLQEKEDLMGEVNYWQGRLEAMWLQ
The following text describes a protein:
Function:
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. DusC specifically modifies U16 in tRNAs.
Miscellaneous:
MISCELLANEOUS: DusB and DusC together account for about half of the 5,6-dihydrouridine modification observed in wild-type cellular tRNA, and DusA accounts for the other half. These three enzymes seem to act site-specifically on the tRNA D-loop and contain nonredundant catalytic functions in vivo.
Domain:
Is composed of two domains: an N-terminal catalytic domain (residues 1-242) and a C-terminal tRNA recognition domain (residues 245-309).
Sequence:
MRVLLAPMEGVLDSLVRELLTEVNDYDLCITEFVRVVDQLLPVKVFHRICPELQNASRTPSGTLVRVQLLGQFPQWLAENAARAVELGSWGVDLNCGCPSKTVNGSGGGATLLKDPELIYQGAKAMREAVPAHLPVSVKVRLGWDSGEKKFEIADAVQQAGATELVVHGRTKEQGYRAEHIDWQAIGDIRQRLNIPVIANGEIWDWQSAQQCMAISGCDAVMIGRGALNIPNLSRVVKYNEPRMPWPEVVALLQKYTRLEKQGDTGLYHVARIKQWLSYLRKEYDEATELFQHVRVLNNSPDIARAIQAIDIEKL
The following text describes a protein:
Function:
Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein.
Sequence:
MIPVKHVLVILMAVWSCCATLDLQSYEERVSEQLSGSPGPRSSWERYEAAVQILQAEANRTGTVEQLQASVQTQTTGAQLNCPLKNSHTVPTSVHSLRPEDVKVVAAIGDSLTAANGAKALTVLGLLTNYRGVAWSIGGEKTLDSYTTLPNILKKFNPEIIGFATGSGGADSRNAHLDQAVAGAVSEDMVGQARKLIDLIKAGEHIDFENDWKLVTMLIGGNDLCDYCEDKEKRSPLKYYEHIKAALDLLHQELPRTFVNVVTVMDVVEIGKLHRTFTCDVLHFFLCRCVSYASEEDLVELQAANMRYMSLTNRLVNSGRYDDRDDFTVVVQPFLEETKLPRTEGGDYDRSYFAPDCFHFSLKAHAAAAKALWNNMLEPVGSKRTDWHVGEPFECPTEERPYFGTAKNSRTSLGGANPSVGVETFNSYFKDFTSQDVSKPTSGSAALVVVGCLLLVCAVVASVFVLRRRRKVKGQVKGQETAPLLSESNDMAATLVMS
The following text describes a protein:
Function:
May be involved in transport of proteins into the mitochondrion.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion outer membrane.
Sequence:
MLQLFIYSPGLGQPTMDPGCLAALIYCALAVPKDEIEILRTANSGMSPTHKLPALWDGHVWIGSLKNILIYLKQKGYNLDNFDAKQLANVMAFTSLLEGSVNDLWLLEAFVNEENFVEAIRPAWSKALKFPHNYLTPNALQRQAKERLAQTLGIRDEEVSYEASRMPISHKWTNATRHRQALLRTQARRIRISSLARQVYGSLESLISDSKFIFGEKPTSLDCLFYAYLSFHAFTNELPQATLRPCLQFNSPKLYAYLKSLRETWFSDDSNILSPLSIKVQPENLLTIARLAWNNVTAKANDTRKSITKFSVPPERKLLWARNGFFIFASAFSFVWFVISNGIVVIETEDDEASFEEVDDAKESIQEKEIDETTESKATHDSSETSSSKELPKEEEKESSSFDLQPLSAQDLLFSGFAEDEIMDEEFGYDDDDDEEFDLDDLDDLEEEIV
The following text describes a protein:
Function:
Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules.
Subcellular Localization:
Mitochondrion.
Sequence:
MFFRVFLHFIRSHSATAVDFLPVMVHRLPVFKRYMGNTPQKKAVFGQCRGLPCVAPLLTTVEEAPRGISARVCGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVTYRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAGFSYKVIRVPPEKVDLGETIHGAQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQPLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRSGQLLPGRYYSKPFVTFHQINAFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLNAPEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHFFYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITPNQNESNFLLVLDAKNFEELGRAEVPVQMPYGFHGTFIPI
The following text describes a protein:
Function:
Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.
Miscellaneous:
MISCELLANEOUS: Present with 2570 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
Homotrimerization occurs through formation of a three-stranded coiled-coil structure generated by intermolecular interactions between HR-A/B regions allowing DNA-binding activity.
Sequence:
MSFSTINSNVNKTTGDSNNNTTENSSTADLLGMDLLQSGPRLMNTMQPNNSSDMLHINNKTNNVQQPAGNTNISSANAGAKAPANEFVRKLFRILENNEYPDIVTWTENGKSFVVLDTGKFTTHILPNHFKHSNFASFVRQLNKYDFHKVKRSPEERQRCKYGEQSWEFQHPEFRVHYGKGLDNIKRKIPAQRKVLLDESQKALLHFNSEGTNPNNPSGSLLNESTTELLLSNTVSKDAFGNLRRRVDKLQKELDMSKMESYATKVELQKLNSKYNTVIESLITFKTINENLLNNFNTLCSTLANNGIEVPIFGDNGNRNPTGNTNPATTTAIQSNNNTNNASPATSTVSLQLPNLPDQNSLTPNAQNNTVTLRKGFHVLLVEDDAVSIQLCSKFLRKYGCTVQVVSDGLSAISTLEKYRYDLVLMDIVMPNLDGATATSIVRSFDNETPIIAMTGNIMNQDLITYLQHGMNDILAKPFTRDDLHSILIRYLKDRIPLCEQQLPPRNSSPQTHSNTNTANSNPNTINEQSLAMLPQDNPSTTTPVTPGASISSAQHVQQGQQEQQHQIFHAQQQQQHHNAIANARSDVAIPNLEHEINTVPHSSMGSTPQLPQSTLQENQLS
The following text describes a protein:
Function:
Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MQNLTSTFVSPSMIPITSPRLRLPPPRSVVPMTTVCMEQSYKQKVVVIMGATGSGKSCLSIDLATRFSGEIVNSDKIQFYDGLKVTTNQMSILERCGVPHHLLGELPPDDSELTTSEFRSLASRSISEITARGNLPIIAGGSNSFIHALLVDRFDPKTYPFSSETSISSGLRYECCFLWVDVSVSVLFEYLSKRVDQMMESGMFEELAGFYDPRYSGSAIRAHGIHKTIGIPEFDRYFSLYPPERKQKMSEWDQARKGAYDEAVQEIKENTWRLAKKQIERIMKLKSSGWDIQRLDATPSFGRSSREIWDNTVLDESIKVVKRFLVKDKV
The following text describes a protein:
Function:
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
Subcellular Localization:
Cytoplasm. Nucleus. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane. Late endosome membrane. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane. Note=Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).
Domain:
The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.
Sequence:
MAMPMPTAPPMENTTLVGHPPPPSYDEISGANPYYPAGPYPPADMKASGPPPYPTQEYNQMYPPTAQGQPVTSPVVAVQTVYVQPGLVFGNVPVQAHCPVCSQSVITRLEYSSGPLVWLSCAGLAVFGCIYGCCLIPFCIEDLKDVTHHCPNCSSVLGVHKRF
The following text describes a protein:
Function:
Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Both the bHLH region and the C-terminal portion are essential for inhibitory function.
Sequence:
MSQREARGARAMPGLGQSPAKATPRLLAGTERKRSRLSRRGQDLWEESSWSNQRWSRTAPNPRGARARSLARGRSEASPENAARERSRVRTLRQAFLALQATLPAVPPDTKLSKLDVLVLATSYIAHLTRTLGQEMPGPSWPPFLRGLRYLHPLKKWPMRSRLYAGGLGCSGLDSTTASNSGQRTKEAEAGPHVSGEPDALLSTRQLSPAPSDK
The following text describes a protein:
Function:
May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YghB, for the proper export of certain periplasmic amidases and, possibly, other Tat substrates. May play a role in determining membrane lipid composition.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MELLTQLLQALWAQDFETLANPSMIGMLYFVLFVILFLENGLLPAAFLPGDSLLVLVGVLIAKGAMGYPQTILLLTVAASLGCWVSYIQGRWLGNTRTVQNWLSHLPAHYHQRAHHLFHKHGLSALLIGRFIAFVRTLLPTIAGLSGLNNARFQFFNWMSGLLWVLILTTLGYMLGKTPVFLKYEDQLMSCLMLLPVVLLVFGLAGSLVVLWKKKYGNRG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MATATFPPPPPFYRLYKDYIENPKSAPEPPPPIEGTYVCFASSYTTDDVLPSLEEQGVRQLYPKGPNVDFKKELRSLNRELQLHILELADVLVERPSQYARRVEDISLIFKNLHHLLNSLRPHQARATLIHILELQIQRRKQAVEDIKRQREEAQKLLKEALGTLAGQ
The following text describes a protein:
Function:
Involved in the digestion of the blood meal.
Subcellular Localization:
Secreted.
Sequence:
MKGPTITTCLYLIYLIVGQASEKISYTGDQLWKITNGNNSTLNLLKTLEQDNYVSIWGHNSTYIDALVHSSALNKVRDKLQEHGQEFKVSIEDVQKAIDEENPKPANLDGRKGFRLTWNYYHSLADIYDYLYYLQQTFPKLCSVHNIGQSVERRPIKLFLISNGKKANKAIFIEGGINAQEWISPAVITYVINQFVSNYQNETLSVQNIDWYIVPVLNPDGYEYSYNVDRLWKKNRSKNKKCVGVDLSRNWGYNWGKNGSSSDPCSNSYRGRRPFSEPETAIVANLFITHPEIDWIGYISVRAYGQYIVYPWGCPNGVLEDHEELFRVAKEAAVKMVSAGGESYTVGPAGIITDSSSGISIGWAKDAQAIKYAYIMKLRDTGRYGYFLPARFIKPTSEEAVTFLRTIAGIIKS
The following text describes a protein:
Function:
Phosphatidylserine synthase involved in the regulation of processes such as cell morphology, cytokinesis, actin cytoskeleton, and cell wall remodeling and integrity. Also plays a role in the physiological adaptations required for stationary-phase survival.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=During log-phase growth, concentrates at the cell and nuclear peripheries as well endoplasmic reticulum membranes, while in stationary-phase cells, is redistributed to unusual cytoplasmic structures of unknown origin.
Sequence:
MVRSRVSPGLKLQSDASNQSNDKENKLLAYVNDNRHFSLIRALHLADLITLMNGFCGVMSIFSSLRYCLSGQQSAFHLWNAMYFMPFALFFDFLDGKVARWRGKSSLMGQELDSLADLISFGVSPAVFAFCCGFQTFLDTVILSLFVLCGLTRLARFNVSVNSIPKDGSGKSQFFEGTPIPTTLSLVTVCGVCILKGKTHENLPWGEWCGNTPFAFHPLVVLFVLSGIAMTSKKLKVPKI
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Subcellular Localization:
Cytoplasm.
Sequence:
MMRNLKVNEASVELRDSMVPSNDGSPSDTTSCISSAGDATVNAKEGDVDRESVVTDQGLPNPACGYYGYFYPGYDGTHGGVDDQAYYVAGDGMEIQYPVMQADNGSLVYLMPGIYPGHSPYLPVTMVAIDGQHVGQHPYPSNTIFQPSIAPGYFPTPFLMPPPYLWDPSTFVGGGYGNDYSGIVEISGAKPNMSSHSHTHAHSKNFLTPDFSDSLKNKTALQSLEVPSGHGTHNQLKSVAKSDVPREGYLPFAKFPPYNQGKGGVLYTVAPVKASARGWSNSERPKARSKISNISNFGSLTEQNYVPRTTNSKGSFAFGGNAAGSLDSDGTGNSNSLTSVIRRDQYNLPDFPTKYDHAFFFVIKSYSEDDIHKSIKYNVWASTPNGNKRLDSAYQDAQKKIAEKGSNCPVFLFFSVNASGQFCGVAEMIGQVDFNKNMDFWQQDKWNGYFPVKWHIIKDVPNPQLRHIILENNENKPVTNSRDTQEVKFPQGMEMLNVFKSHVSKTSILDDFDFYESRQKVMQEKRLRSLVTHLDHNQKADELIGEEIEASGKAKE