lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD
The following text describes a protein:
Function:
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate.
Sequence:
MAAYKLVLIRHGESTWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPMVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK
The following text describes a protein:
Function:
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Subcellular Localization:
Secreted.
Sequence:
MCAERLGQFMTLALVLATFDPARGTDATNPPEGPQDRSSQQKGRLSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIRGLHGICMTFLHNAGKFDAQGKSFIKDALKCKAHALRHRFGCISRKCPAIREMVSQLQRECYLKHDLCAAAQENTRVIVEMIHFKDLLLHEPYVDLVNLLLTCGEEVKEAITHSVQVQCEQNWGSLCSILSFCTSAIQRPPTAPPERQPQVDRSKLSRAHHGEAGHHLPEPSSRETGRGAKGERGSKSHPNAHARGRVGSLVAQGPSGSSEWEDEQSEYSDIRR
The following text describes a protein:
Function:
Could be implicated in synthesis of very long chain fatty acids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MELAEFWNDLNTFTIYGPNHTDMTTKYKYSYHFPGEQVADPQYWTILFQKYWYHSITISVLYFILIKVIQKFMENRKPFTLKYPLILWNGALAAFSIIATLRFSIDPLRSLYAEGFYKTLCYSCNPTDVAAFWSFAFALSKIVELGDTMFIILRKRPLIFLHYYHHAAVLIYTVHSGAEHTAAGRFYILMNYFAHSLMYTYYTVSAMGYRLPKWVSMTVTTVQTTQMLAGVGITWMVYKVKTEYKLPCQQSVANLYLAFVIYVTFAILFIQFFVKAYIIKSSKKSKSVKNE
The following text describes a protein:
Function:
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MEGGAKGKEKKKPLDVFNDFKARHADVEEFFKLCDPGKENLCLYGLPNGQWEVKLPAEDLPPSLPDPVVGINFARDGMPQKEWLSFIAYHCDAWLLSVAFHASGRFGFDKADREKLFDMINDFPTIHNLMTDDPETQQKEQPTVTDKRKNKSKPNPSKRASESQGKLTKLQKKYEEEEDDNGEDIGEEEEGEEGWDIEKDDEEMQDETLSPLPQPSTLSNTSAALAAAKDTGVSVRDIVNVEFSCCLMQEAIHDVWKKCPSFTVMKLQALYLKSDFLKTNFRRRMSELVPQWIDVQTFVNLCCTVTPISGV
The following text describes a protein:
Function:
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Miscellaneous:
MISCELLANEOUS: The 3D-structure was determined for the synthetic analog Triptorelin.
Subcellular Localization:
Secreted.
Sequence:
MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI
The following text describes a protein:
Function:
Putative odorant or sperm cell receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
FQRPFIRDMGIKNATELTEFVLTGLTYPPAWQIPLFLLFLMLYLVTIMGNLGLITLIYNDPHLHIPMYLFLANLAFVDTWLSSTVTPKMLVNIITKDKMISLHECMVQFFSFVVSATTECFLLATMAYDRYVAICNPLLYPVIMTNRQCLRMLVSSFVGGLSHVFTILIVLVSYTRVLFTILKKKSVQSIRKAFSTCGAHLLSVSLYYGSLLFMYVRPGSAQADDQDAVDSLFYTVIIPFLNPIIYSLRNKKVIDSVRKKTNLNRLHIVMCRLVLNIFFHHNCPVTLMTSNVSAS
The following text describes a protein:
Function:
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence. Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo.
Sequence:
MLILSALGAFGSPFDVEMHERNPYARPPDFARLCAAHADLRPHCKLVANGKVHLDFADDAAVRALTRALLKQDFALDVDLPSGSLCPRVPQRLNYLLWIEDVIVASGLDADAVRGIDIGTGASCIYALLGARRFGWSFTATEAELSSSEVARQNVARNGLSERVDVVKTTVDGAIIEDVIASSPHPHYTFCMCNPPFFDGDGETGERFVERGEEGKEVGGRKEWENAVVGGKRPAPRSGTVAGENELATEGGECAFVGRMFEESARMRDGVRFYTTMLGKKSSVAVLMGRLARMREEEDEGKEGKRLRFASGELRQGRTQRWLLAWTWDARVRLPLRPASLELVMRECARTEAMQWIRTQLLSLHVAIERDDNDEEVEGGRMECRVATPSWLRRGRKRKKTLATGAKAHCVAAPGPCEAAPPTPDPAPFLPLDFSVSCRQRATYTLSGQARRLSIDESPGADSTTVVVFTVGDGQRKRDLAQLVVHLSNRRSVGK
The following text describes a protein:
Function:
Catalyzes the sequential condensations of isopentenyl pyrophosphate (IPP) with dimethylallyl diphosphate (DMAPP) to yield geranyl diphosphate (GPP) and with GPP to yield (2E,6E)-farnesyl diphosphate (E,E-FPP).
Domain:
Contains two aspartate-rich DDxxD motifs, designated as FARM (the first aspartate-rich motif) and SARM (the second aspartate-rich motif).
Sequence:
MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRLRPLFAYWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQLRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDDVLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSIGTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGLSELAMMAANRSA
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTKGKGRNPGASGLDKHLKRKTHLERSQPKSRQHLGQLEKHKDHVLRAKKRKVKVRRLQEIKRAAAQRNPDEFNIGMTKAVMDVANGRMRQRRVRLVESDRKKDMQTTIEHNRRNVQYLEFKAQADQQRATELLNEEAAAALTSTAPQNKHIVFVNSEEEFRSFNPLKHFDVTPEMMRQHPAVRGRIRVLEKTVMPEEILMSGGHQIKSAAQKRKERREVQEKMRRSGADATPETRAAFVERLRAKKELKQYQFTDLLEEVKRESEATASSSKGAPGDDGEQEEAAAQDEVTRLLEWRREQERQAAIATARHVREVGQRIQRSKSLSALAKSIRKQSQGIKRQMEQRRESRFKPGATRRAR
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDWDQLEVSPRIIAAVKKANIKSAGNILTLSVPELQKLANLSVADVHHLQRAVSAVLRKNLGVTALQIYSEKAKFPAQHQKLSLGCKVLDNFLRGGIPLVGITEIAGESSAGKTQIGLQLCLCVQYPVEYGGLASGAVYICTEDAFPSKRLQQLIKSQHKLRSDVPTEVIKNIRFGDSIFVEHTADVDTLTECITKKVPVLLLRGSIRLVIIDSIAALFRCEFAAKDAAIKAKHLQTLGAKLHSMSSRFLTPVLCINQVTDRVREMNSEQIDLGLQDKKVVPALGISWSNQLLMRVMVARTQHIAPAEHAGGILRTMEVVFAPHIPQSSCYYTVDLEGVKGLDDYTQS
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MAEDDTSSATPHGEAEEKEEKEGRKLKKSGSSDDMNDTQRMISYISHRFSNLDIDALNSLEAIEDLLGIAQEDIQIWDSDESMIWESKPGEAFRYLRAVEELQKLTGSLETFRWTEDVELQSGILCRAHSVVHMAMTKLEYEFIHLLTKYLHVPQLDATSFRSDGGLSLTLTDEYNYSHRSFESYPNVSTMIADLTVPNVRPDIRCIAQVMFNSNYGRECCQAYVGVRRDVLDECLNSLLGEILSIEQIVLMDWKILNSKIHRWKKVAKNFVNVCLVREKNLCDHIFEYLPDEPAARYFFESSKASIYRLFKFGEAVSVIPSTPEKLFEILDMYDVLGELIPEIKSLFENTPDSSCSSILSESQHVRFRLGESAKSVIECFKHDVQKTKSTVAFPGGGIHPLTKYVMNFVSTLSAYTETLENLLGVEVGNTIQEEEEEDAEEERLHSSHRVSTVLLRSLIKMLESNLEAKASLYQDISLQKIFKMNNIHYMVNKVMANSELRVILGDEWIRSHCGEYVRCASGYQRITWNPIISLLIDERFNSGNEGTNNIHSSSRNHQNHQRPPKMLLKERLKRFNAMFEDTYKTHTAWNIPNPNLRLEMQINIAQNLLHAYRTVMGRHSAILDGFPHPEKYLKYSTEDLENYTTDLFTGNSKSLNPTRRGA
The following text describes a protein:
Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work.
Sequence:
MERFWLQPLLTAPSPSREGSLGFSRPCISPVFPGPASPRFFQDLHLPGCEKQEGREGLLERRRRRGMQEQEEEEGTFCCARGGWHPSPAPRSRAAAGGQAPRPGREGEGVWGRPDAAAPSSPAAMPFSNSHNVLKMKLAAEEEYPDLSAHNNHMAKVLTPELYAELRLRRTPSGFTLDDVIQTGVDNPALASLEGDLTGKYYALKNMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDGRGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIESLFKTKNYEFMWNPHLGYILTCPSNLGTGLRGGVHIKLPHLGKHEKFGDILKKLRLQKRGTGGVDTAAVGGVFDISNADRLGFSEGGVCERGGRETRKPHLSPPRSTVLDFY
The following text describes a protein:
Function:
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLALILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREAAQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
The following text describes a protein:
Function:
Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. Is required for growth on either quinate or shikimate as a sole carbon source.
Domain:
Consists of a fusion of two distinct domains: an N-terminal sugar phosphate isomerase-like domain associated with DSD activity and a C-terminal hydroxyphenyl-pyruvate dioxygenase-like domain. This C-terminal domain does not show any 4-hydroxyphenylpyruvate dioxygenase (HPPD) or protocatechuate dioxygenase (PCD) activity, but appears to be important for optimal DSD activity of QuiC1 in vivo.
Sequence:
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLHYDGSPRDVRRLCADLGLEILLFQPFRDFEGCRRERLGRNLERAERKFDLMQELGTDLVLVCSNVAADALGEPALLADDLRQLAERAAVRGLRIGYEALAWGRQVNTWEQAWDLVRRADQANLGLILDSFHTLSLDGDPRGIADLPGEKIFFVQMADAPLLAMDVLEWSRHFRCFPGQGGFDLAGFLAPVVASGYRGPLSLEVFNDGFRAAPTRANAVDGLRSLLYLEEKTREHLQRQTPHVAVDELFAPPPASLCDGIEFLEFAVDETLGARLGQWLQRLGFARAGEHRSKNVSLLRQGDINLVLNAEPYSFAHGFFEAHGPSLCATALCVRDAGQALERARAYGGQPYRGLLGPNEREIPAVRALDGSLLYLVERHTEGRSIYDSDFVTNDADTSGLGLRRVDHVALALPAEGLDSWVLFYKSLFDFGADDEVVLPDPYGLVTSRAVRSPCGSVRLPLNISEDRNTAIARSLSSYRGSGVHHIAFDCADIFAAVAQAKEAGVALLEIPLNYYDDLAARFDFDDEFLSELAYYNVLYDRDAQGGELFHVFTEPFEERFFFEILQRRHGYAGYGAANVPVRLAAMAQARRGVRRVKL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDYNREVRRATHETMTNLVSAVGRDLAPHLKPLIGPWWFSQFDSVSEVSQAAKRSFQAAFPAQERRVDALMLYSSEIFTYIEDNLKLTPQSLSDKATASDELEEMHQQVLSSSLLALAALLDVFLYSHSEKPGPENVTGELKHAVKARTIAVSSAEKLCSSHKYFQDFLKSQSPAIRSAAYSVVKSCIKNIPNAISEGDMKMLAGTILGSFQEKNPACHSSMWETVLLFSRTFPDSWTTVNVQKTVISRLWNFLKNGCFGSQKVSYPALVLFLEIVPSKSITGDKFFLDFFRSLWEGRHMSFSSNTDRHAFFVAVEECFIWAVRNASRYCVGAEAIYLFQHTLVDEVLLGFLWPEYLLAASSKNQDSAFSSSILDQSKNGIQSNHKEPREALNSKHSIDYEESLGKCIVKILSAIQRLDNNLFLVFSSKFQADILDIFHQTEYSSQNVRWVVKFILLLDKHAVRNGEIWPLLDLIGPTLQKSFAVIGTLDSPDAVTVIVTAVSVFGPRQITQQIMCIGLGAEEFLKSFIETIIPWSLKRFSPSTAARLDLLLALLDDECFSKQWDAVIRYLVIQEKVSFDPGTMDRNYISVLAILMEKVKERTKKSVHQSDQCEDWHHELLDLVAVYVVQAFPQFGDSDARFICAVLGGGTIDDKISFISRKTVILIFEEVLTRLMTFMKDSTFSWVQDVCSLLYSGSKYSDWKLEPSNNLLEMAHFVLDILNGSLFCLNTIEAERELVQGILAAIFIIDWEFSCINVSEDKLNKEHIGETGSRLAFCEAVHAFRCKIRDQFLRGFGVNNRKSLGTTLVQSIKCITFVDNRFESDNFVSLCGQWTLDVFEIFCQDQVEEQQLLEQFLSKNDSWPLWVISDGIGARLRTDNVSLSLHAPSNTKFIALVDKLISKIGFDRVVAGLISEASPSSTKDSPTDLGINKTHYSRPWLAAEILCTWKWIGGCVLDSFLPSFVSYMKNGDCGFSDSILNVLIDGALVHGSCSGLNLLQRASVDELEAVDEPFLRALLSVLSTFFQDNLWGNEKATSLFKLLVDKLYIGDNANLNCLKILPSIMNILVRPLSIGAEDRTNDLSDPYSESKLHNVTVDWLNRTVCFPSLSTWQSGEDMEDWLQLVISCFPVEVTERMQEIKPARYVFPAERAVLYELFQKQRQGASAVLNKLPLVQKLLSELMVISVAYCWEDFDEDDWKFVLHRLRFWIEAAVVMMEEVVENVNHTLANGSNDVNASLNEFENAVVISDPFPVELARNALVGFSLFCSLIGSQDKEHAGNLNHLGSEKWEIMTDRIFEGILRLFFCTAASEAIANSCCHEASSIIASSRLGHRQFWESVASCVLQSSSHARDKAMKSIEIWGLSKGAISSLYALVFSCKPLPPLQYAAFVLLSTEPGAQLAFTCDTGKVSNDGTLNNEDSFDTSSAENVHLREELSYKLEKLPPRVLEMDLVAHERVNVLVAWCLLLEHMTSLPSSSPARERIIQYVQESTSSVILDCLFQHIPLELYMGSSSRKKDAELPAAVSEAARRAIATSSVSVSVQFLWPIGPEKMASLAGAVFGLMLHHLPAYVRGWFSDIRDRSASSAIEAFTKAWCSPTLISNELSQIKKASFADENFSVSVSKSANEVVATYTKDETGMDLVIHLPPSYPLRAVDVDCTRSLGITEVKRRKWLMSLMSFVRNQNGALAEAIRIWKSNFDKEFEGVEECPICYSVIHTVNHSMPRLACKTCKHKFHSACLYKWFSTSHKSTCPLCQSPF
The following text describes a protein:
Function:
Phosphatase which plays an essential role in the development and differentiation of the ookinete and in the formation of ookinete micronemes.
Sequence:
MIFKKALYILLFLYIAIVKKGESKPGSKHPFLFKNLVIDKKKLDSSYYNKYDNIKWNGKIIAIGDIHGDIESLKLILRHSKLIGENDNWIGDNVLLVQNGDVFDRGIYGPIIYNFLFKLQKEAIKKNSRVILIMGNHEQLNLCGYFNYVNPKEIEMFFHNDANYRYHSFVNPYGEYHKRLIRLPPMVKVNNIIFTHGGLNLLISKLSINDINLKTRLQIENNCKPIKYDSFQNYLSRDGVLWSDAMSRNVPYYEKEKCSELFQILDKYDAKYLVVGHTRQPSHQIGSYCNNHYFLIDTGMSLFTNYGQPYPNYLKIDDHKIKAVRLIVEKKKKCPHTEIQLNTPNKIKYCVQESQTNLNPVL
The following text describes a protein:
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Sequence:
MDFSSIEQNLNNFKKLVAGNSDKAQITPVLVQLKLAATIHLEKPTSLSNVSDKVKKDLVLAREILELISLYSIKIKDIDSFERTFNQLKTYYYDYKSIIAPSTLEYQIIGLNLMRLLAKHKTSEFHSEIELIEFNNLDNSFIKFPLLVEKSITEGSYNKIIQSRSGVPSEYYQVFLDILADSIKEDIANCSEKSFKTLSLKDAEKVLLFNDNNQFQQYIKERNWKVQGDVIQFGNNDNQTVEIPSLQLIHQTLHYAKELERIV
The following text describes a protein:
Function:
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
Subcellular Localization:
Nucleus.
Sequence:
MDEAVGDLKQALPCVAESPTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVRDSQPIDLSACTVALHIFQLNEDGPSSENLEEETENIIAANHWVLPAGMGNIHGLWDSLVYGCGSQIRCKLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGKLCRLLFDQISGMKFSLYLYLRPSARSYPACEVPGPVLFDPIAPSQQVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIICPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLAAYI
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence:
MATTSSSKQMEVNPRGIPRAPFVDNVDEYVGGKDAEVQTTIKKFEETTAKYRYMEISLQQRRKALLGKIPDITQTLQVVKYLHQRRQKTLGQPVEEEKLSDDEDDLDDLDDEEAKKEEQPMKTLFELNDTLYAEAEIVETGEVGLWLGANTMLMYPLEEAIDLLSSKLAAAQKSQDETIEDLEWLREQITVMEVNFARVHNWDVKRRREKGQIGQQSGLLPSRKGNDKDDSEDERD
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MADSQEIPVNVPSIAEFFSGKSVAITGATGFIGTCLVEKILRCCPGVLKIFVFIREKKDKSATERLAHLTQLQVFDTVRTQQPDFQLKLVAVPCDLEKEGFDLSEESQTQIQNEVNIFIHSAATLRFNEHIRLSYQINTLGVRTMLKLCRTIKNLVSIVHISTAYSFCDRKDIGEEVYKTGWNFNKLHDTMQWMNDDMLTKLTPDILRDRPNTYTLTKAFGEEVIVKEGEGLPVCIVRPSIVGATYSDPVAGWCSNFNGATGLFIAYGKGLMRSLYVKRDICMDIIPADLVVNGTIAAAWRNALSTHRKTLPIYNLVASSSNPVLMREWMLSNVDDIMTSSYTNYPLDALMSPDLKVASNKLMFRVFLFFKQYIPAYIFDAGLILIGKKPQLLRWTQRVSGTIGVLQFFLTSQWNWSNNSIQKLQREMNEQDRKQFNMDAAVVDWEQYMNNYAKGTKKFILKEDPMNYPAARRHVQRLRILGYCSQLLVFMVVWRLLVPRSGIAKNLWHLFMSLWFKFLGFFQISSTLHR
The following text describes a protein:
Function:
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAFAEHSPLTPHRRDLCSRSIWLARKIRSDLTALMEAYVKHQGLNENINLDSVDGVPMASTDRWSELTEAERLQENLRAYRTFHVMLARLLEDQREHFTPAEDDFHQAIHTIVLQVAAFAYQLEELMVLLEHKVPPSEADGTPLSVGGGGLFEKKLWGLKVLQELSQWTVRSIRDLRVISSHQAGVPAHGSHHVAKDKKM
The following text describes a protein:
Function:
Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.
Subcellular Localization:
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Sequence:
MSSTNIEQVMPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLSELDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLADEAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVWFMGHDSSKFRITESVFRFGADVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEENQPDSGEEE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVHQLSLVSSIPHNKYLQTISTLQALTGLIQPESISTYTLLAKPSYAFKPKFEPGKVNQIEQYYMRCITTWNSDKQGDDEKVEKGFDISEPFINKESNIVVRKLFTEEDSVERVWTLQVSDIPVAGKNQGCCQQQIYESTLVHTHTAIEIKVGNGDPIDIDTNNDKQGDNNTDKPKQEHDGKLPEAIDEDIIKNGDEKKTTHDDNDSDIMEIDEPNPETQTLPQSLSNGVSQRTTRKDSFLIFLSDLGYEVINQYWQKGVRFFYGDIIIEIYKIFIRDESSQADSNEGIKLKLLDDSNQFQIKAYININKSTEIDSINSGVKELIKLQEFLKNLFVLEIPDRMFMDSRIKQ
The following text describes a protein:
Function:
Serine-type protease active in vitro against the LHCII N-terminal. Cleaves its substrate on the carboxy-side of Glu residues.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MLRAGAAGPRVLSSLIARGCADSKPVLTRGLLSGNVGGVVRGWPTQTGGLASLSPVRARAAARMCVLAAHLGAEGSAPADVPGTGTTGATAAAPAAPSAPAGSGLPLSSAVGGAAIRAGGGYKLPPPEIAAIVDAPAQPALSYSPDRKLFLQLDRPPSLPPIYEMARPELKLAGVRLDPELYARSKMSYYTGISIVPSTEVVPAAADRCRHVTGYPPGSWLNYVSWSPDGTKIAFTVRSPGGPGDPPRRPLELWLADPATGACRPALPAPGPGAPGPLGLGYRALNTVFDDYAWLDDDTLVAAVLPAGLSPPPAKPPLPPGPKVQDNTAGKKIQNRTWPDLLKDEHDVALWEHYGTSELLRLDTRTGQAVVIGPPRMYIEVDPSPDGRYLLVSWLERPWSTALPAGRFARRTQLWTRDGSLVRELAALPLAEDIPIAFNSCRAGPRGISWRDDAPCEMYWMEAQDGGDPAVEVSPRDVVFGLSAQAAAADPAAAPRRIAQTDLRCGGVAWCDGDLAILFESWYKSRRSVWWRFAPDRPEQPKEVVFDRNYEDVYGDPGSPLTRRTQWGTYAIARITPDPATLEALQQAADDTEAAEAAAEAAAAATALSASSGGSDAEAATPTANGSPAAAAAPAPAPASATKRVTRAGLASGTGTWLLMSGSGASPEGNKPFLDLFHLESGETHRLWQSRPPYYETSGSIMSDTDPHQPITLEGLSMMFGRESSTDPPQTHLRTLTDAGRSWQERQVTNFPHPYPQLRELQREVLRYPRSDGVMLTATLYTPPGYNPKTHGPLPCIVWAYPREFKTKEAAGQMRRSPHQFTSIGSTSPTLWLTRGYAVLDGPTLPIVADVKEESEGSASTGPAPEPNDTFIEQLTDSARAAVTEVVKRGVADPARVSVGGHSYGAFMTANLVAHAPDLFAAGIARTGAYNRTLTPFGFQNEERTLWQAPDVYNRMSPFMAADKITKPLLLVHGEDDNNPGTFPLQSERFYQALKGHGAACRLVLLPHEGHGYRAYESIMHCLYEQDQWIERYAGYGRLDPGYVTEDSAGPDGSASE
The following text describes a protein:
Function:
Involved in the secretory pathway. Essential for membrane fusion mediated by either SYP41 or SYP61; triggers the fusion of phospholipid vesicles containing SYP41 or SYP61 and VTI12.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MKITALLVLKCDPETREPVILANVSDLSQFGKFSFYRSNFEEFIVFIARTVARRTPPGQRQSVKHEEYKVHAYNINGLCAVGFMDDHYPVRSAFSLLNQVLDVYQKDYGDTWRFENSSQPWPYLKEASDKFRDPAEADKLLKIQRELDETKIILHKTIDGVLARGEKLDSLVEKSSELSLASKMFYKQAKKTNSCCTLL
The following text describes a protein:
Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Vital for female fertility. Required for learning/memory.
Sequence:
SRSPLAGNDGAVSPSGAALVLQNMPQRRESFLYREEDMSPKSMSRNSSLASEGRKTWESSKRIDVEHGEDLIVTPFAQILASLRSVRNNYICLTSIPINRSRRSSQSTGVSTPQPKNLTPGDETYSRLAVETLEELDWCLDQLETIQTHRSVSDMASSKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQELDLPSLRVDDSETEKARLSASGPRNGATPASSSASSSHVGRAMSHISGVKRPLSHSNSVTTSEKVAKYGVDTANEHELGKFLDEVDRWGIDIFRIAELSSNRPLTAVTYAIFKQERGLMNAFKIPDKTLVSFLMTLEDHYGKEVPYHNHFHAADVTQSTHVLLNSPALESVFTNLEIMAAIFAATIHDVDHPGLTNQFLINTSSELALMYNDESVLENHHLAVAFKLLQSPDCDIFSNLNKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLQNMVHCADLSNPTKPLDIYRRWVSLIMEEFFQQGDREREQGLDVSPMCDRQNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDGLEDNRDWYFSMIPPSPPPAHNALSVPSERIQFQITLEEGESGNEEDD
The following text describes a protein:
Function:
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts. Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification. Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway. Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement. Brain osteoanabolic hormone (By similarity). Drives osteogenesis in osteochondral skeletal stem cells. During lactation, maintains the maternal skeleton and viability of offspring (By similarity).
Subcellular Localization:
Secreted. Cytoplasm. Cell junction, gap junction. Note=Localizes at the gap junction in presence of GJA1.
Sequence:
MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELELKTTRGKM