lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSWIGINAIWVELPLLVRLAPESWALASYIVIVIQIANIGPFIYTISKSAFPEKVKEWPVIIATIIVGMLASVLLIFFWNVTTVWVGINELRSTGLLVLSLFLSLVDCTSSVLYFPYMSTFDSQYMTATFVGEGMSGLIPAIIGLAQITVEQNVSENPVVNNYVPKSSNINQIELFFLLNDSSQNGTTPPKKENDYVKERFSVSIYFLLIAILLSISLIMNLHDYENLKQTDKFGIGFLLMTAWINSLTNGVLPSLQTYSAQPYGSLAYNLHVKLSVLVNPLACFAALFIHVNKFWIVVVLTLFGSVLAAFQIALACLSPNPPLKKTSIGIACLVATQVVLIAILSYTKVTIATIVSRMQGRQWLLFFGVATQVGSFVGASVTFCLVNYTDIFQSEY
The following text describes a protein:
Function:
Probably plays an important role in neuronal membrane skeleton.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
QNMTSATDFDHLEIQQQYSRINARWDASDDELDNDNSSARLFERSRIKALADEREGVQKKTFTKWVNSHLARVTCRISDLYMDLRDGRMLIKLLEVLSGELLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIIVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFEKLKHSNARHNLEHAFSVAERQLGITQLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVMDHAIETEKMIDKYSGLASDLLTWIEQTITILNSRKFANSLAGVQQQLQSFSTYRTVEKPPKFQEKGNLEVLLFSIQSRMRANNQKVYTPNEGKLVSDINRVCNIKRNHKQLNSFGPKAVLKYSQLKTINFNFGQDNFGNDLPAVEAAKKKHEAIETDTAAYKERVQAIEDVAKELEMENYHDIKRINARKDNILRLWEFLQELLQARRRRLEMNLTLQQLFQDMLHSIDWIDEMKVKLLSPDSGKHLLEVEDLLQKHKLMEADMAIQAEKVRGVSAAALKFANGDGYRPCDPKMIRDRVNHLEMCHRELMALAAERKARLEQSKRLWKFFWELDEAESWIKEKEHIYSSLDYGKDLTSILILQRKHKAFEDELRGLGTHLQQTIKEGETMIAQRHFGASQIRTRIEEVKALWAQLQELASFRKKNLQDAESFFQFQVDADDLMAWLQDAHRLVSSDDVGHDEYSTLALVKKHRDLLDEVADNKRVMDNLNRQAQSFPTEFRDVPGFENRLKAIQTAYNEVVSLADLRRQKLQDALDLYTVFSETDACELWMGEKEKWLEQMEIPDTLEDLDVVQHRFDILEQEMNNLASQIDGVNRAAIGLIESGHPRSGKVRQCQEHLNARWRVFQEMVAQRRKAVDFALSLHNYCVDCEETRKWILEKTKVIESTQDLGKNLAGMIAMQRKLYGIERDLAAIQARLATLQQEAHRLAEEQPDLADDVYSRLTAVTGVWLDLQNTLQSQEASLGEASKLHKFLQDLDDFQAWLFKAQKAVASEEVPNSLVEAEHLLQQHTAVKEEIDQHRDDYRSVKDIGTRVTQGQTDAEYQQLEQRLQGMDTGWNALCKMWDSREKFLNQCLGFQEFLKDAKQAEIILTNQEYTLAHIEPPDTLEASEASIRKYEDFLATMEANEEKITGLVNSGNKLVSEGNIYSDKIKEKVHLIQERYKTNVTKSQEVFVLLKDNHDLRNFLRNCQELTVWIEEKMLTAQDISYDEARNLHSKWLKHQAFMAELASNQAWLDKVDEEGQLLAEQKPQYEDIVCRRLADLHQLWDKLQATTEEKAQHLFDANRSDLYAQSYADLGAWISEMEQQLKSDAQGKDLTSVNILLKNLKRLEEQVSVRKKEMEDLLSQAPPTRGDLHEVDGKHEIIERRFQGLLEPLSKKRRELETTKAGYQLDRDLADELLWVQERLPLAQSTDHGTNLLSVQLLTKKTQTLQKEIAGHAPRIEEVLLRGEGMLAGADSDEDFKDTEERLGQLKDSWNTLQEETLQRLHRMEEASEAQRYYLDAGEAEAWISEQELYMVTDEKPKDEESGIVMLKRHLRQQRSIEDYGKSIKQLAGRAQKLLSAGHPEGEEIIRLQGQVDKQYAGLKDLAEERRRKLEHMCHLFKLKREVDDLEQWIAERDVVASSPEMGQDLDHVTVLREKFRDFARETGSIGQERVDSVNLIIEQLIDVGHPEAATIAEWKDSLNESWADLLELIDTRMQLLAASYDLHKFFYDGGEILVLIEEKHKELPEELGRDVSTAESFHRMHTAFERDIHLLGTQVQHFQEVAARLQAAYAGEQAVTIQKQEQEVVKAWKALLHACEGRRGQLVDTAEKFRFFSMVRDLISWMESVIRQIETQEKPRDVSSVELLMKYHQSIKSEIDTRDKSFITCIDLGKALLHRKHHAAAEIKDKLMQLTEKRREMLEKWDRRWDWLRLLLEVCQFSRDASVAEAWLIAQEPYLSSGDYGQTVDGVEKLLKRHEAFEKSTATWEERFSALERLTTEDPKDKPASLSVNPPPPPQMKNREYQVQENEKPGQEMVPEQLPEENIPETEITVDSEEISTKESLFKVAQTPVSEIDETATLPAQLDRSHSVQLEGYLARKHDLEAPNKRASNRSWNTLYCVLRNSELTFFKDAKSLALGVPYHGEEPFRLKNALCEVAADYKKKKHVFKLRLSNGSEWLFHGKDEDEMHTWLQGFSTAIIESQSIKTKAQSLPLPSITTVDVSLTKKEKEKRFSFFPKKK
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MQVYLAVLLLAATAVLGDDASTPAPPTGNQQQQQQQQQQQFYQPPDPELVKTHLQKLFDEQLDTDKDQYATAAELKAYLKKFHSRLIDDSIDKQWLYFDKDMEEKQPGVKVLKWDTYRKLSFPDKDLEEKGEDGATGRQMLERTERRWKLADADGDGALDKSEFKSFLHPEEDDRVRHVVVLEATEMMDSDKSGEVSFEEYMQHLRKVSGPEKDKDKDWSQAQQSHFSTYLDKDKDGALNMDEMRDWVLPSHDREEGEAWRLISVGDINQDTKLTREELAAAPDYFMGILPHEFWQQQGHAGGVKHDEF
The following text describes a protein:
Function:
Required for resistance to DNA-damaging agents.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYTHILVAVAVTPESHQLLAKAVSIARPVQAKVSLITLASDPELYNQFAAPMMEDLRAVMHEETENFLKMLGEKADYPIEQTFIASGELSQHILAVCRKHHVDLVICGNHNHSFFSRASCSAKSVVSASQVDVLLVPLAGD
The following text describes a protein:
Function:
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Domain:
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Sequence:
MAVVELEVLHYGIIAILLILPVLYETSATFKYFAKFVLYDTIVLTIAVFLMPILAFRPRDVNNYRIVSWTVKNAMKIFAIKIDIKHRERLVSDQPYILVSNHQSSLDFIGMMELLPDRCAFLAKRELLWAGPFGISSWLCGTIFIDRLNPEKARDTMDQTAETLHTKNIKLWIFPEGTRNHNGSMLPFKKGAFYLAVQAQIPIVPVVFSSFSHFYNKKERKFETGRVTATVLPPVSTEGLTKDDVGDLTEQVRKTMLQTFNETSLPRMEPNGYS
The following text describes a protein:
Function:
A probable inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression. Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization as well as MreB ATP-dependent polymerization. Restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX; overexpression of this protein and CptB also restores Pig production to a slightly lesser extent in Serratia.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQEWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
The following text describes a protein:
Function:
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
Sequence:
MGIWNMDIMLQTSFVKPPPTMQGTAHLYVANCGPDVGLAFSDIKKAFEIFGSVENVQLAGASGSRVYVSYHNVDDAVAARNAWNLKPCDALQGRVMVIQHAVPQTQSSVEEQVVFTSSADVGVPGLTLYTDFVTLSEEQELLREVDERSWQTLAKRRVQHYGYEFLYKTRNVDLSQKLGELPASLEPLLNKISLVPEIASAEEPTLPFDQLTVNEYPRGVGLSPHIDTHSAFEGSILSLSLGGPCIMEFRKYIKRGNSLVDGDAHTSTSISQQNDESNENAEAIVVRNDDSVPTGSVYIIRKALFLPPRSLLILSGEARYAWHHYIPHHKIDNVNGQVLDRGTRRVSFTFRKVRPGACNCPFIEHCDSQVSDAGELALQNEEIKESTKTLEELRSNDEIPKTPSEKQSMSAEMGNEPKHFNTTIPEIEKRYVHKVYNAIAPHFSDTRFAKWPKVAMFLESMEPGSVVADAGCGNGKYLGFNKKCFFVGCDISPPLIGICAQHGHEALVADALHLPYRTGFFDAGISIAVLHHLSNEERRLRAMEELLRVVRRKGRVLFTVWAVEQEDKKLLTKWTPLTCKYTEEWVDDTGAAFKRNLSMNSLKSIQEVESQVPTAIPSEDLKDSSTEGVRLSSMEKAAAAQQYILNEDLSTHDGKMKGEQQEYFVPWHLPYHRAEIAGASAAAIADGLARKDDVKRALVYNRYYHCFVEGELERLASKIQCARLVDHFYDKSNWCVILEKI
The following text describes a protein:
Function:
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.
Sequence:
MEADITNLRNKLKECEDERLKAAQYGLQLLERQTELQSQLDKCHEEMMTTAENYNQEKYALQREVELKSRMLESLSCECEALRQQQKAQLEQLEMQLHRSHRQEVHGLRNKLENLKVELDEARLSEKQLKQKLDHQGELLSHKSEELRLLSEQRALSSVSSELLSLQTELTEAEGVKNALREEVNELQCKQEQLECLNASLLHQVDRLKEEKEEREKEAVSYYNALEKARVENQDLQVQLGHALQQAADPNSKGNSLFAEVEDRRVAMERRLNLMKDKYQSLKKQNAFTRDQMNKMKLQISTLLRMRGSQTEFEQQERLFAMLEQKNGEIKHLLGEINKLEKFKNLYENMESKSSTSDSACALEDSTYYTDLLQLKLDKLNKENESTKGELSIQRMKALFESQRTLDIERKLFANERHLQLSESENLKLRAKLDELKLKYEPEERIEVPVLKRRREVLPLNINTPEETAAASATGEDVSRLPLERKEESCLDNLKDNTVQWKQPASLSPHKSLPLDTQPKKEKCVTLVASPASTEVLHEQSGNTPSSPRLTEESRLPTKVKERKEATSKLEKGASKKSHTIMYVSSKSTPEMQCPQQ
The following text describes a protein:
Function:
May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.
Sequence:
MQAIHENYTDNPSSSITRERQHEDMKGAQFVVQSNLKIMSRSIAALSKISEDVLIEVSEGGLFFKTVNRSKFCVFRFAPEFFNACDVSMINKKAVNICRLSMKSAQRIFKGVAFGEKNFVGCEFRIDPKAERMMVKLQMNYDIERTIHAKLREMGSMLHKPTYNRSGCRNITVVFASTLLPIFVQMKGDIEVTMKVTDDGLTIRNFHSLDGVTMFNMGVEKGAKKVKTETTITCEKLTRHKIQIPVEFSFSIKEFLSIVTFADQLGSEVCMYYDLPGKPLIVSIEAHPNFDIELALATMGSDDEIDLDGGILKETMAQHEEEEDKSTAHSSSSRRKSKAIDTSSSGTQKSKKCSESLSQEETTRSQSLPSRNRFVPEIPVAEQSWRDREVTVYEQREPSPDLQIVEEVMEIDNQPIVTRTIKEEHSVEQAMQDVSIETIPVETPEENIIPVEVEMLEEPEQEDQEIFKIPQPKRRKTAEDDRNRKIRRILMGTETTSKMRMSQQFDKRLGPLVSDTQYESR
The following text describes a protein:
Function:
Converts fungitoxic kievitone to the less toxic kievitone hydrate, and thereby protects the pathogenic fungus against this phytoalexin.
Subcellular Localization:
Secreted.
Sequence:
MMISSVLVAGVVAVSAALASKHPKQYSFKPEDAETIWNGDIPVLYDFGDSQSASYSGSWWTSSYITGTNGEQYLVISHYLDTPVFTYFRASTLNLETLDYNQFITLGNNTANSTTLDVKVGDNGIQSLTADNISQQRAYANDENVTFDITFDATSRVISNAGAGVFQFGPSITYEWGLPNCRTQGSVTDTGGKNITVDPAKSFTWYDRQWGTAAVTSGNWTWFQMHIPETSYKLSVWIIDNDVTNQFSRFATIRGDNDEFQVLPLEWKPIYDRTYQSTAADILYPLDWELDISGFGVFQLSSILDDQEIVGTTAIQTAYEGFVTFNGTVHNKKVQGYGLVEVVYSNWESL
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAQNDTVKLIGSWVSPFSIRARAALHLKSVKYEYSDEPDSLNIVQYIDEAWSSGPSILPSHPVERANARFWAIFIDEKIITSLEAVGGAKDDEGRMAAAGKLMENLAILEEAFQKNSKGLGFFGGENIGFLDLACGTLLGPVSVIEAFSGVKFLRQETTPGLIQWAEKFRAHEAVKPNMPTPEEFVAFAKKKFNVEWWAFS
The following text describes a protein:
Function:
Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin which is used as a precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis.
Sequence:
MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVEPEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSDAELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRRKK
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion. Plastid, chloroplast stroma.
Sequence:
MPPPLQAQRLLLSHRRLPSPHLRCFTAVSSLPSAPAKTVAAAAAHAPSSILSIRESLLSGERTAAEITAEYLSRLRRTEPSVRSFIHVADAAAEREAEELDRRIATEGLDAVGPLAGVLVGVKDNLCTANMPSTGGSRILDGYQPAYDATAVRRLREAGAIVVGKTNLDEFGMGSTTEGSGFQVTTNPWDDSRVPGGSSGGSASAVSARQCVVSLGSDTGGSVRQPASFCGVVGLKPTYGRVSRFGLMAYASSLDVVGCFGSSVVDTATILSVIAGHDKMDSTSSSHDVSDYKSELVPLDLLESKPLNGMRIGIIQETLGEGVETGVISSIKDAASHLEQLGSVVEEVSLPSFSLGLPAYYILASSEASSNLSRYDGIRYGRQVSGDDLNELYGGSRANGLGHEVKMRILMGTYALSAGYYDAYYKRAQQVRTLVKKSFKEALERYDILVSPAAPSAAYKIGEKINDPLAMYAGDTMTVNVNLAGLPALVVPCGFVEGGSAGLPVGLQMIGSPFSEGNLLRIGHIFEQTLQNYSFVPPLLAES
The following text describes a protein:
Function:
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLSEQFISSIRAQPRTANTAISKDIGIYLHTLHPSPKIESHFKKSSTSVNSLAANSSHIFAAQADKAVIHVYSRQNGNQEALISFPERLHSLTLVGDGLVVLGTSEGRVILWEIFTGRQVSTSAAHLQPISCIAATSTHMVTGSEDSNLHVWSISQLLSLHSNTSEPHEPIRSLSNHRAAITSVIMGHGSSTSNICISASKDNSIIVWNYHTGDLLRTFLLSSTPLCMALDPCDRAVYTGFEDGSLQMIELIQPNSSINPLFDTRLQNTPVQVTSSIWSPPSDIGTVHCLGLSYDGTSLFSGHSSGKISHWDTGRRAFLVELSDLNAPVTNLVMQSPFPKTSKIKSINVVKPKLAEGNYTFTAQLIGNKGSSIFDQALEYQGFPQGMIEKALLNLSEPQVTTTSSSSSSSSSEEEKLRKENSELWKVINEQRALQKKTFEKYSELKTGGV
The following text describes a protein:
Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Subcellular Localization:
Cytoplasm.
Sequence:
MPPDLRMQPLPFPMMTLTSETKLDLEKAGVLVLGVEPSADSGESSDGKTTANCIAVSSLPESLAATVKNACSSGEVTGKPGELTSFATGNAQTPWIVLAGLGASDKRTRGSAIELGAAVVRSLASKPRQQITFALGDGVATENHDAVVAGAVSGCEGQHLYQREPSISVPEAIAFVGYSAESVSRGEKLGQSINHTRRLVNEPPSIMNPTGFAQYAEKIASDCGLTCEVWDEKKLEAENCRAILAVGRASTSPPRLVMLRHDGGGDEAPLVVVGKGVTFDSGGLSLKPSDGMVDMKCDMAGAATVVGVMNALAKLKVPRNVIGLCGLAENMVSGDSYKLGDVIETRSGKTIEILNTDAEGRVVLADTLDVAVQQKPQAIVDLATLTGACMVALGIDVAGLMTNNQALCDAVQSAAESECEPVWQLPMFSLYDDKVKSKVADIKNVGEGRWGGAITAAKFLENFVADVPWVHIDIAGPAFVDSPKPHRDAGATGVMVRSLVRWIENAS
The following text describes a protein:
Function:
Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1.5 repeats for binding. Bends telomeric DNA and may provide chromosome stability. Also required for development of AWB olfactory neurons.
Subcellular Localization:
Nucleus. Chromosome, telomere. Note=Binds to telomeres.
Domain:
The N-terminal and homeobox regions are together sufficient to bind telomeric DNA; The C-terminal region is required for bending of telomeric DNA.
Sequence:
MTSYSYFTIPSTATTGFNYPVQPMTMFSGAPYNAAMIPRKNRRERTTYSRQQLEILETLFNETQYPDVFARERVADQIRLQESRIQVWFKNRRAKYRLQEKQKPKRSNEKSQEHKSEDQQQTDVLDGEPLKGGSPGYQPQIKSELESCDGAVASGKLGTPKSISPVETTASTTSSNTSAAELQWNGDHKILGFGKNETTTSAAVSPTADNASTPSSSSSITATSSLPTTSSSLSVYNYPAIYPQWGLDYSTYANPQYAQFSHNPYAGTPFWYSNGNNL
The following text describes a protein:
Function:
Transcription regulator controlling zinc-responsive gene expression. Binds to zinc-responsive elements (ZREs) (consensus sequence 5'-ACCYYNAAGGT-3') in the promoter of target genes. Recruits SWI/SNF, SAGA, and Mediator complexes as coactivators in a zinc-responsive manner. Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation of the zinc uptake system genes ZTR1 and ZTR2. Positively regulates ETR1 expression, affecting mitochondrial function.
Subcellular Localization:
Nucleus.
Domain:
Uses 4 of its 7 zinc finger domains to contact the ZRE. 2 of these (ZF4 and ZF7) dominate the interaction by contacting the essential ACC--GGT ends, while the other 2 (ZF5 and ZF6) contact the 5 basepair central ZRE sequence. 2 zinc finger domains (ZF1 and ZF2) do not contact DNA, and a third ZF3 may be more important for interfinger protein-protein interactions. ZF1 and ZF2 bind zinc in vitro but less stably than zinc fingers involved in DNA binding. ZF1 and ZF2 are critical for zinc regulation of activation domain 2 (AD2) and play a role in zinc sensing and consequent regulation of ZAP1 activity. ZF1-ZF2 interactions stabilize the beta-beta-alpha folded repressed state of the ZF2 activation domain in the presence of cellular zinc excess. DNA binding is inhibited by zinc; Contains 2 zinc-responsive domains ZRD(AD1) and ZRD(AD2). Zinc binding to residues in ZRD(AD1) and ZRD(AD2) represses the activation function of AD1 and AD2, respectively; Contains 2 activation domains, embedded within larger zinc-responsive domains (ZRDs), designated AD1 and AD2, which are regulated independently by zinc. AD1 plays the primary role in zinc-responsive gene regulation, whereas AD2 is required for maximal expression of only a few target genes. AD2 recruits coactivators less effectively than AD1 and is therefore only functional on some promoters. AD2 is also important for ZAP1 activity under heat stress conditions.
Sequence:
MDALTPRDSPKRDDSMATSAATAASAKPDALTIGKEGIVHGHIHNYNNLTYIHGHLHHSAPVNDSSASATPAAAAVADAATSAFASGASHDMGGDCHVNEKCKEYTDCQHFEFLNYHNNPSLTKYNDTATYNSNNHSFANNFHSVASDPTSPQQNSKSDLPRRKDSWFNDDLILLPSSKKNKPNPPPGSDDCYCTPKILEICCDETHPKSEANIKQGESDQPTKKDISENGNDVAIFTDVKNDHLMPNFNLHDQYCNSTNHDSHNHNNTVPDSFSQLMSHLSEIDCDLTCDTPCTASTSATSGHKFVQDHQSSNNDDVFHKYCKFCEESTDNQPCSKHMHLESKPPQLPPKCSSLRKPTNTLQGTNHAYHEHILNTDMDLKILEDLCNISSLYEVPFGKHINHHDHNNAGNGCDGSSTGNNENGNQTMNLLLSSINRCNPKNNLNGSNNNTAGATSTDHQHHHHRIQFHSHKPNRNNIVNNSGISAANTTADLTNNDLNDLISREYSYERFRNQSEPPSLPKVTHQNQKNRRSWPTKDLESTDFSSLEDSLPSSISPPIQTTSTINFNWCFKEEKNNDLKCKWKECPESCSSLFDLQRHLLKDHVSQDFKHPMEPLACNWEDCDFLGDDTCSIVNHINCQHGINFDIQFANPDSFLPGSISKEKHHLLHCPNPQTHEVSKADGAPDMTSANDVSNIPPIKQPEQVICQWDGCNKSFSSAQELNDHLEAVHLTRGKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSEETLVQHTRTHSGEKPYKCHICNKKFAISSSLKIHIRTHTGEKPLQCKICGKRFNESSNLSKHIKTHQKKYKCSDCSKSFDDLGKLNSQKVKCALERKPYL
The following text describes a protein:
Function:
Plays an important role in sperm motility and male fertility (By similarity). Required for sperm midpiece flexibility and for the localization of sperm calcineurin to the mitochondria (By similarity). Promotes mitophagy as well as acts as an autophagy mediator in male germline cells (By similarity). Links damaged mitochondria to autophagosomes via its binding to the outer mitochondrial membrane protein VDAC2, as well as to key autophagy machinery component ATG16L1 (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Cytoplasm. Mitochondrion.
Sequence:
MVTHAAGARTFCEEQKKGSTYSVPKSKEKLMEKHSQEARQADRESEKPVDSLHPGAGTAKHPPPAASLEEKPDVKQKSSRKKVVVPQIIITRASNETLVSCSSSGSDQQRTIREPEDWGPYRRHRNPSTADAYNSHLKE
The following text describes a protein:
Function:
Binds to the 23S rRNA.
Sequence:
MKLNELSPSVPKKNRKRIGRGNSSGWGKTAGKGSNGQNSRAGGGVKPYFEGGQMPIYRRVPKRGFSNAIFKKEYTVISLAFLNENFEDGEEVSLETLFNKCLIKKGRDGVKVLGNGELNKKLTVKVHKISKSAKAAVEAKGGTVELVEVKGFERAETNK
The following text describes a protein:
Function:
Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance.
Subcellular Localization:
Nucleus.
Sequence:
MTDHPPIDTSSYFDCYQQHQLPLQYTFTSSSNSNTSNSSTSPSHISDQFSSSGGPPYELSSHILTPSSVIPTPSPSVASASISSPTIPAFGCTMSEYSMEQMEAISTSLFQARDGDRLVAFFKQLESLYGPNAVDHLRSEAIIVAYTYALYHSNEFETLFHLLSNRHFQQRHYNDLQDIWHHARYKESQLKRGKELNPVEKYRLRRKFPAPKTIWDGEEIVYSFKDSSRKFLKQFFRNVSEYPTQEQKREISRATGLKIVQISNWFKNRRQRDKSNNSAKCSPPSSSSSTNGGSDFLPIITPQSFNLAAAPFNMNMIYGTLRDSQSDNDQFTFNP
The following text describes a protein:
Function:
The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
Subcellular Localization:
Virion.
Domain:
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. The matrix protein contains one L domain: a FPIV motif.
Sequence:
MPSISIPADPTNPRQSIKAFPIVINSDGGEKGRLVKQLRTTYLNDLDTHEPLVTFINTYGFIYEQDRGNTIVGEDQLGKKREAVTAAMVTLGCGPNLPSLGNVLGQLREFQVTVRKTSSKAEEMVFEIVKYPRIFRGHTLIQKGLVCVSAEKFVKSPGKIQSGMDYLFIPTFLSVTYCPAAIKFQVPGPMLKMRSRYTQSLQLELMIRILCKPDSPLMKVHTPDKEGRGCLVSVWLHVCNIFKSGNKNGSEWQEYWMRKCANMQLEVSIADMWGPTIIIHARGHIPKSAKLFFGKGGWSCHPLHEVVPSVTKTLWSVGCEITKAKAIIQESSISLLVETTDIISPKVKISSKHRRFVKSNWGLFKKTKSLPNLTELE
The following text describes a protein:
Function:
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
Domain:
The C2 domain is required for RapGAP activity.
Sequence:
MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEGAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
Subcellular Localization:
Chromosome, centromere, kinetochore.
Sequence:
MSVKVITTKQPSYLEALLQENCNLKLVYHDKKAESAHVIASGDESNIPDVSELDLTGHPLQVDLGGDDVIENGISEKPANWSSQEASQFPLTFSEGRTFINKQLRLGSPNESIYCICDGSDEEKTVGLGVVVAPHKNIRTLVRILPCCEENSEQTSLEHLQNEFLKLLGDYNADVKICIKKTYNLFGYNLKNCHALQNAECNGNITLDVLTVEKSKFYKSNHVSKMNFQVIIGHNNSRIRRLFEELCLVQSYIAVIQNNQQLNANTIINCEDGMDYSDITSKIVDLLRVQEIYSERPSFNKLDLENLRETSIFDKLWDILKHCKSVGDLHDCFQLFFEELEVVEARVGILEGCNDSTVAELVKGILDDRVVVTTLSLPQCLEFLIDLGLVKLKNDYLAIITSFPQIARDGLLKMWSDFKGEDCVNIIPKRKSRVTINSKSVISDMTSSKLKLFFLDSLHKVSELMLLYRDNLPVSDENFDAFCRAVCDKFIDRFERVIVWIDLKQLRLCQVSGVPSIGERQFLQNNSPSAFAVKMNSVVNREEITAVYHFSDFLILPPCVYDNYEVSCEKDSGKMLYVTQLLSYNDCC