lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the presentation of foreign antigens to the immune system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGASGPKRNTSSPWYHPLRLLLLLLLLWDVVVGTGSHSLQFFSFGVSEPGPRVPEYIVFGYLDDQLIARYDSEKRRVEARAKWMEEKEGPKFWDSQTLRGLSWQSRVMKYLNTIMGYYNHSGGSHTFQHVVGCEIRGDGSTRGVRQYAYDGQDYIFYDTETRTWAAANPVAKITKRLWEADTAHEAQRKFDLEHECVYFLQKFLKYATKHLGRKVPPSVWVTHQKTPGGESTLKCWAHGFYPRDIRLSWWRDGQELTQETEHVEIRPGGDGTYQCWGAVGIPPGEEHRYTCRVEHQGLERPLTVIWEPPFEPSPFIAGAVAVLTLSIVAAVTWMRRKRRRRRGTRPAASGDPVGEDEGHERGAFLEMSAAPAPPTQPTPGPPAC
The following text describes a protein:
Function:
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Sequence:
MEVIAGTYSHLIFGYEVKPNEEGKLKFSTSFTNDSHAGVVKCLTVNRRGFLASGSADESIRLFSLKGRRCEIGSLCQHNGSIVSLKFFKNSYLFSASEDGTIAIWKVNSWDCLKVLKHKEALTDFAIHPSGKLLLSLTKGRTLQTWNLLSGRRAFVTNLKQVGEMIWFSNDGNRFVIVMGNNIDIYTTADALIAHSYNHTSRISSTVFLNNEILLVGDEGGVVNFLDVTACKLTHQLKTNTVRVKAMQCIQQSSSSSLSSSTLFISSSDGYVKLYDVTIENKIVTTSFVTGVVTPHRWLCMAVYDANGKEEEEEDEEDEICAESFKKSKQSGKSPKKKATTSTVKSDDEEGNDEDGENDDEDEDVDDDDDDGSELEEDDGEDLGTGDNGDDDDACGSDKKLSSGKRKQSFPDKQLKKKQKFAGKNDDESGDVRLKKSNKIVKKKSSKENGSKNDSAKREDYVTFSDDDDDTKKPKNKKFQSKYKFKSHKKAFNGKEKYVSFTDDDDNTKKSKNKKFQSKIKYENHKKGSSRKGKHVSFADDDSDYRKNNKKFRPQYKKNKSKNNNSPKKTANNRFNSKRRFNKRTKK
The following text describes a protein:
Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
Subcellular Localization:
Nucleus.
Sequence:
MNPFDKNPNFRPPGSESATLPPHSITMDPEFAVFSEPPSSPFINLEAFSAGEEGLGVVQPMECLHGTQIPPFLSKTFDLVDDSSLDFIISWGSKGESFVVWDPVEFSRMILPKNFKHNNFSSFVRQLNTYGFRKVDADRWEFANEGFLRGKKHLLKNIQRRRSPQSHQAGSSSAEAGKGAMDEIEKLRKEKSSMMQEVIELQQQQRGTVQQMEVVNEKLQAAELRQKQMVSFLAKVFQNPTFLARLRQMKEQGKITSPRTMRKFVKHQPHDQDRVESSIEGQIVKFMPDFQDLVTSFENPDINLVVDQQLPETGFGAEAMLFKNQERVIEGALNFNPEDSHFEGRNVASPQLEVMPECFVSFPEELAKEKNILGFSSPGIESMVKEEEVWSMGFEASAGMSSTGIELWGSLSNYDVPDFGVSAGLSDVLWDIDPLQEAGSSGVDKWPNDESPFGQPKNDSF
The following text describes a protein:
Function:
Strongly inhibits glucose induced insulin release from the pancreas.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Secreted.
Sequence:
QNCFVADERIISILRHQNLLRELQELALQGANERKQQQKKNSDFEDELSEVLEGQNGATGPGQEPSKESPAEVPDEAAIAETSPRDSFEEAEKNGVERKQLWPQGAGPEEEEEEEEEEEGELESNEITEDPEVERREASDNHIKDDLEPAERPSQESGEGGKDHQLGATQKGQELEEEEEEGEKGINPQNDLEESRELEEEAQKEQAGEKEISEEVVPEGAVKSSTTLEENEEIQREDSHLETSDLGREEKSSEEEDKSQEGKGERRQTEAGDMAADDLFPSRGSRNQEPGSEASREWRDAKRWNKMDKLTKQVTAKKRAEEEDSEEEPDRSMKLSFKTHKYDFGEAGRPKKHHSKEESVEAGLPLPLRGDPEDKRDEEGSANRRTEDQELESLAAIEAQLEKVAHKLHQLRRG
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MASAGSSGGSVTELASRLYDACLSNFPIDHLFYQQDLLGLNIIPKNDLPLLLQCTQSLVDQKLLRLLQGKNDRLAWKLIPREDAEKLQNLSPDESLVYNVIHSTGRSGIWVRAIQNRTNLHKSILDRCLKSLEGKNYIKSVHNVKFPSRKMYMLAGLAPSEDVTGGAWFTDGVLDENFIGVVSGFIEFSVSKKSWYEVPASDKSRHKRLKTADGSAATTVKKEGSQKEYLPYPPGYTGYPTIAMLTAAVNQSGITPVRLGEESVTQLLEMLCYDNKLVALNNGEYYKSLKNPEEVKARQARKPDEELAAADDRLVRNGMTEVPCGNCPVFNLCVPGGAVSPENCEYFETWIHELGPLSF
The following text describes a protein:
Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Subcellular Localization:
Nucleus.
Sequence:
MGIDSLLKALKSVTKPRHISEYSNKKIAVDTYCWLHKGIFLCAQELSEGRETNEHINYCLKKVEQLKKYNITVVMVFDGAKLPSKKSTEEEREKRRNDNLQKHLEFKQLGEKDKAYSKLVESIDVTPQMASRLLDALRTRNIECIVAPYEADAQLAYLSITEYVDVIITEDSDLIAYGARKVLYKLDKFGYGEEIDYESIQTCTEYNFQNWHHQKFLTFCILSGCDYLGSISGIGIKRAYQVVATSQNYKQAIDNLQRKQKVSVPFDYVEQFEKAYLTFLFQRVFCPVQRKMVSVNTFDTDLLYPQMKSLLEGNLDFLGNVYTDTLIQDIADGRICPQDLKPYSQSSKNLKQQSLDNKQQNENNDQLEIPTFGNSRPVQVFKFIKKSQSTKINPEESFERSGESKVINQSQIINSKSTEDNEKYLIENQQIQEQSNLFSSQQETLKQKSLINSNILANQNKKKSSKIIIKHEQKKINQYFQPSFKPPPSVVQQQEQTPSEVNIIEEEIQKIEQKVDSQVEEEFQQYSISEEYSDNFQKRFYYTDFGFFLSQELQFKQIQL
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MKLTVSFCGGGSSSSTAAASPKASNKSKSTRRSSKDGNKSGGGGSSFSSTASASSSHECKSAVTTPRTVLLPVPSSSPPRAPRTAGTTSSSRKPPAAVTREELEVALRRVVSSEEELAEMLAEVDAGLVVPEELVGGDDDAADDDEGNLREVFAVFDADGDGRISAEELRAVIASLGDDRCSVEDCRRMIGGVDVDGDGFVCFDEFSRMMMHGL
The following text describes a protein:
Function:
Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose (By similarity).
Subcellular Localization:
Periplasm.
Sequence:
MKIKSALLTLVGALTVFSSSAHSKDLKIGLSIDDLRLERWQKDRDIFVNKAESMGAKVFVQSANGDDSAQISQIENMINKNIDVLVIIPHNGEVLSNVISEAKKEGIKVLAYDRLINNADLDFYVSFDNEKVGELQAKSIVAVKPEGNYFLMGGSPVDNNAKLFRKGQMKVLDPLIASGKIKVVGDQWVDSWLAEKALQIMENALTANKNNVDAVVASNDATAGGAIQALSAQGLSGKVAISGQDADLAAIKRIVNGSQTMTVYKPITKLADKAAEIAVELGKNEKIEANAELNNGLKNVPAYLLDPIAVDKRNINETVIKDGFHTKESIYH
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Sequence:
MRVRYKPWAEDYLKDHPELVDMDGQHAGKMTEWFDKTQPIHIEIGSGMGQFITTLAAQNPHINYISMEREKSIVYKVLDKVKEMGLTNLKIICNDAIELNEYFKDGEVSRIYLNFSDPWPKNRHAKRRLTYHTFLALYQQILNDEGDLHFKTDNRGLFAYSLESMSQFGMYFTKINLNLHQEDDGSNILTEYEKKFSDKGSRIYRMEAKFHSQK
The following text describes a protein:
Function:
ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLALA
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
LDCFLAFTANRETAFVHSINAAAVTYFLTRDCRRGIFRNCACVRQTGQAGEWRGCNDNVKFGEVLSKHFLNARHVDKRKARAVIHLHNNAVGRKVMVRIRRSHLRCPGSIPGVEKFYFSLFLYNEEKNLDKIDFQLYEIPIWSRSGALTAVARVLFPVWKRSRRSLVFLKPSPDYCHRDTKKGSTGVLGRECSSDSPNYLECIQMCTSCDYRVEKKLAVRSSKCNCKFVWCCDIKCSECKKLVAVTKCVR
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MTVTYSLDVASSSFFCLYKLLFRWKGSIWKSVWAELVVWLALYAVLSAIYRYLLSMGQRATFEDLCIFFDTYSNFIPITFMLGFYVSAVFTRWWQIFDNIGWIDTPCLWITQYIKGETERAKCVRRNCIRYSILTQAMVYRDVAASVRKRFPTFNHLVTAGLMTEKEMAEFESIPSPHAKYWQPMHWLFSMISLAREEGMIASDIIYVDLMEKMRQFRVNILSLTLFDWVPVPLVYTQVVHLAVRSYFLVALFGRQYLHPDRTRVPDYKHTIDLYVPIMSVLQFIFFIGWMKVAEVLLNPLGEDDDDFECNWILDRNLQVGLMVVDTAYNRYPTLEKDQFWEDAIPEPLYTAESAMRPLNPQVGSCAEMPTEEEPFMVRPRRRTLSRMSHWDGDMEDTDVVPVVGLKHLPDGSNYASGESLAFSNSFANGGRKLSEMFRRMRAGSRIGDRYRKRHSSAQDFETGSKKKNSLDDEVETFSNKLDQASGTPKSGRLWSSLPQTQLEEMLKNRNLGGPVKYNTDGMKEKELSNPTPVTDHIDLPSHVPTSPSWYNDSLPVIKEEEEAKRKSNTDTDSLKSSKTSKASIRRTELRRSSSSGSDLGKSGRHERKKSE
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAEKEEKEPSKLKSSTGVSRPTISLPPRPFGEMFFSGGVGFSPGPMTLVSNLFSDPDEFKSFSQLLAGAMASPAAAAVAAAAVVATAHHQTPVSSVGDGGGSGGDVDPRFKQSRPTGLMITQPPGMFTVPPGLSPATLLDSPSFFGLFSPLQGTFGMTHQQALAQVTAQAVQGNNVHMQQSQQSEYPSSTQQQQQQQQQASLTEIPSFSSAPRSQIRASVQETSQGQRETSEISVFEHRSQPQNADKPADDGYNWRKYGQKQVKGSDFPRSYYKCTHPACPVKKKVERSLDGQVTEIIYKGQHNHELPQKRGNNNGSCKSSDIANQFQTSNSSLNKSKRDQETSQVTTTEQMSEASDSEEVGNAETSVGERHEDEPDPKRRNTEVRVSEPVASSHRTVTEPRIIVQTTSEVDLLDDGYRWRKYGQKVVKGNPYPRSYYKCTTPDCGVRKHVERAATDPKAVVTTYEGKHNHDVPAARTSSHQLRPNNQHNTSTVNFNHQQPVARLRLKEEQIT
The following text describes a protein:
Function:
Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
Sequence:
MRVFFFGGKGGVGKTTASSAFAVKLSEQGKKVLLLSTDPAHSLSDVFNTELQGETKLSENLTVKEIDLNEELKEYRSRVFKLAEATLRKETLRELEGIIHSLEESPGIEDVVIFEALSKEVVYRENEYDYIVVDTAPTGHTLGLLKTVRNLGNFLEEIVKLKEKVYELKKLSGKSVHEEALEYLKERKERFKKFSEIIYDKSYFFAVLTPEKLPFEETKRLVNSLKHYGIRVKALIINKVLPENPQDEFLKARKEVEKKFLKEIENYFMDIEKISIPYQKEEVVGYEKLKEFSKFLPLG
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPSFIQNWPLHAALLLTFNCSLTWLNLVSKEVPEPYLDEFFHVPQAQKYCDGDYTWDPKITTPPGLILRTLRTPRSQNAPLNVKDGDKDPDLNDSTLILDANTALNIALFPPLFFFSALFYTDVMSTLVVLLSFHMFLKRSTFGNLLQSIGTIFIGVVALFFRQTNIFWVAVFPAGLAVIDALKARAPSSTSKKPHIVGDILRESWNNGLVHDCALKHASLQDYGLLVVTVAIAAMRSPALVLQVASPYLVLLVLFASFVIWNGSVVLGDKSAHTATIHLPQMLYIWPYIAFFSAPLVVGPMARPAVMLLPKQFQALFERYHITPTTSKFPEILSVGLFILGAFLAVHFNTIIHPYTLADNRHYVFYVFRILRRHPAIRYLAVPAYYACAWLVTNAVGASPNDEQPLKQKRENGHPTNIKTGRTPCQISFFTIWLAATALSVVTAPLVEPRYFIIPWIIWRLHVPSASASLPSQERCIRSWYDLRLGLETLWLLVVDVAVTYIFLYRGFEWPSEPGKLQRFLW
The following text describes a protein:
Function:
Required for the transposition of the insertion element.
Sequence:
MRQISSRYLSEEERINIADLRRSGLSIRKIADQLGRAPSTVSRELRRNSRRDGQYRPFEAHRWAVQRRVRRHRRRIDKNPDLCELIAELLAQRWSPQQIARHLRRKYPDDRSMWLCHESIYQAVYQPQSRLIRPPQVKSPHRGPLRTGRTHRRAHLRPGRRRPRFAQPMLSIHQRPFDPADRSEPGHWEGDLIVGKNQGSAIGTLVERQTRLIRLLHLPTHDAYCLRIAITETMSDLPVTLVRSITWDQGIEMARHIDITADLGAPVYFCDSRSPWQRASNENSNGLLRQYFPKGTSLSTYTPDHLRAVEYEINNRPRQVLGHRSPAELFTALLTSPDHQLLRR
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MAATTTTTNAGRSMASWKRLSTLIAAFTLSWTSSFVAAAGSADYFVHDLPGAPDGPLVKMHAGHIEVTPDNNGNLFFWHFQNKHIANKQRTVIWLNGGPGCSSEDGALMEIGPYRLKDENTLVYNDGAWNEFANVLFVDNPVGTGFSYVDTNAYIHELTEMAANFVTFLERWFALFPEYEHDDLYIAGESYAGQHIPYIAQAILERNKNAGPVNRKWNLSGLLIGNGWVSPKEQYDAYLQFAYEKDIVKKGTDLANKLEIQQRICQKEIAVKPDKIDYPECEAILQDMLQLTAGGVGASGKNQCYNMYDVRLKDDYPSCGMAWPPDLKSVTPYLRKKEVIKALNINDNKSTGWTECNGQVGMNFNPKTKPSITLLPDILSAGVPILLFSGAEDLICNHLGTEALISNMEWNGGKGFELTPGTWAPRRDWTFEGEPAGFWQQARNLTYVLFYNSSHMVPFDYPRRTRDMLDRFMGVDISSIGGQPTDSRLDGEKLPETTVGGAAGNSTSNQAAEKAKLEMAKWEAYRKSGELVLVIVIVAAGVWGWFVWKERRKTAGQGYMGVATGERHSISNNPGPRGNLSGGGDRTRGQGLAGFRNKRSGRRDVEAQDFDESELDDLHLSKPEDPHADSRYSIGGASDDEEEQKPGKGSSSRQPGGRS
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2268 (m5C2268) in 25S rRNA.
Sequence:
MVARRNKPKAPLVKHRFSGGDSHKPKPPPATKQPFSGVESHKPKTSPATKQKFSGVESHKPKTPPGKQRFSGAESRKPKTPPATKQKFSSLERSALYARREAANILRTVLRGDAERRAVASIKSLVLSPSVRNKRGTFALVCETLKYLTVIKDVLDIANVLNSKWKRQEPLVFIVCYDILFGKDTPSIGDAEKFLMRHKEALLSGLATLLVRKKVDSVDQLLGSKLTGHLKPRYVRVNTLKMDVDSAVQELEKHYTVQKDETVPDLLVLPPGSDLHAHRLVANGRIFLQGKASSMVAAALQPQAGWEVLDACSAPGNKTIHLAALMEGQGKIIACELNEERVKRLEHTIKLSGASNIEVCHGDFLGLNPKDPSFAKIRAILLDPSCSGSGTITDRLDHLLPSHSEDNNMNYDSMRLHKLAVFQKKALAHALSFPKVERVVYSTCSIYQIENEDVVSSVLPLASSLGFKLATPFPQWQRRGLPVFAGSEHLLRMDPVEDKEGFFIALFVRANKLDNPKSSELPDRVCRRRPKERTMQLHPYLCPKMFRAWSGTLHRLKTRFLLSRNGC
The following text describes a protein:
Function:
Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDGFALIWGCLLAIVLAQVLAYILCHHRLPLFIRATYEWGKLLDENTSAFNRKWLVPKSCNKQQKFLCYQIIIQVKEVFGYLDSANYYTIKTSSIILSLVLLSLQTFRRLYECLFISKFSQSAQMHLGHYLLGGMFYILVNLTIISDGSFLTSDGDTFRLKDLSTATNIIGVCIFCWGSLHQHRCHNILAQLRVGSSSHNNYGVPRGDWFNYVSCPHYLSEIIIYFSIGFILSLDHQSWWLLLAFITTMLSLGAVQTNQWYYQNFSNYPEDRRAIIPFLL
The following text describes a protein:
Function:
Involved in maceration and soft-rotting of plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MFNINVVNNYGTGTNTQAVALTAQGERHVYSMCSFSSYQDTLYVKSTSAYFLGCNIEGAVDFIFGGGTAWFEKANIVVKPPRSFATITAHKRVQASSPAKFVFNLSNIVGAPGTRAGSAYLGRPWSALAAVTFQFCSLSNVVNPAGWAAWNPPQDSRTQSVQFYEFQNSGPGSQGRRLFGKASVLPLKIEQVLGPNFASWAT
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSYYDIDSILTDAQKLPCTFELDVPGLGILEGNPGESADPRTVDLRSLAPNYYRLSERVLELFEEEEMVDILSNVTTPTLQTSLDAALLTRTDQTFKKRAAEIADHAHNPKGALGDGVEFLQGLDETERQLFRVAHDGARETRIWAGEAKKR
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
SPGILSCALSSRWWQGEARELQRQREVTAVTESNCGSQERKGLPKRLWGGGGWPHPRRPRALGSGRVGADGGQEAPSLQQPARAVLSVAAFTRVSSVLDQALRPWVNPLAARASVCSSVKRGIPQRLGQPKGVRRAPRFLPLSSRLGRSRQGGCAPTPRLSNALPAATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYALFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
The following text describes a protein:
Function:
May have roles in neural function. Ectopic expression promotes axonal regeneration. Also augments motility of gliomas (By similarity). May also have roles in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration (By similarity). Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MVYYPELLVWVSQEPFPYKEMEGGLTKGRLPVPKEVNRKKMDEPIAASLIPPGNHEPGSPAIGYLHPF
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
Sequence:
MIVDYEKDPRAKEAIAIWEKGVLKEKDGSMSDAINFYRSALKIHDNVESLYRKKILDEWMLHKKLSGLSMTTDAPDEQNETGKDDLSVEENAELQPCWILEILPDDILLRIIKKVILMSGESWVNLSMTCSTFSKLCFHDSVPFKTFAKYIYSKQIYDKMAMDLNGITDINTFEKEIWRGDDYRMLRERPYIKFEGVYISVVNYVRYGSNAESSLSLLKPVHMITYYRYFRFYENGQCLRLLSTDEPSAVVKHFSKENKPRHSHMCYWSLGFDYDFGHLKITRSDEKYTFIEEFQIKNQGNKRYQRLKWLSSIVVDKEGNASNCSLRNEKSFFFSRVKSFKDPG
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MAKRDYYEVLGVNLNATEAEVKKAFRRLAMKYHPDRNPGDKDAEVKFKEAREAYEVLCDSRKRASYDQFGHAGVEQTFGGAGAGGFGFGDLGDIFGDIFGDIFGGARGGQAREQRGADLAYELVLSLEEAVHGLSRTIKVPTWINCKTCNGSGAKGSSPATCPRCNGSGQMRMQHGFLQVQQTCSVCRGRGQVIKDPCTDCHGQGRQQQTKTLSVKIPPGIDTGDRIRLAGEGEAGLFGAPPGDLYVQVRVKPHPLFHREGNDLHSEVPIDFTTAALGGEMEIPTLDGSVRLTIPPETQGGKQFRLRGKGVKALRSGAVGDLICHIVVETPVKLSPEQKDYLKQFAELLKKDEKNHSPRTRNWFDSVKDFFTSK
The following text describes a protein:
Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome. Membrane; Multi-pass membrane protein.
Sequence:
MWFAIVVTVLAAAGNNIGKVLQKQATRTLPRLVLNRQTLLLYLRSALWVTGMLVDLGGALLMIVAFANAPVSIVQPVSAVGLVILLIFSHFYLKERLQWHEWLAACVAFVGVLGLGASAEPSHMDHPDISAWRVLGAFSGLVALLGLECWWRHTHTGLGSGHSGAAHHHHHHQPAVGVNGGKPPPRVSSANSHLHQAPPGSSAAAAAAAAAAAADAVLCGLEAGACFGFSAAACRTGFILAAKLSMVWVPLGLAASVALTSSGFLLQTRGLKAGNTVIVCVAAATSSMITGVAAGMLALDEKLPSGHGMKLVRLTSWLFILLGVSCLAGGTEALAATARAFASCLPPWAWRLLPRPVAVTVHKLQKQRTQQQHQQGMGSEEDDEGLEDLV
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MKTKTHHTLAWPYAVRLLAFADEITKLQLSPDKLFIVLRLHKVLSSDFFTILQWHPEEFSIAKYNHTMQKLRQAVFHVLQELKVLIQKRASRSVPEAEGVHEVTCYVMNYIRLLFDDKSMDSLDHIVQDLITCLEAMLNRVAEAYDSEALKCFFLMNNLQFIVKQVEDLGAEDFVDQYMETYLDLSWGPILSCLSTRKTMLGCCFRRSSNIVRFCLKFDSTYYNQEHWKVEDPLFREMVQQTVCNKVASAYQAHIEKSRKVQRQYEWPQDIFPAPDILENLCVFSSFHFGS
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MNLSGKELEEQLKEIGSELLKPPSSTDALLKGLDKAECLLTNVEQSPTRSMRDTLLPLMKALISDKLLKHSEEDVKVTATACITEITRITAPDAPYDDDKMKVIFQLTLEAFRKLSNVSGRCYMKALSILDAVAKVRLCLVMLDLECDNLILEMFQSFLKLIRSNHPTAVFSAMEAIMTNVLDESEEVSSDLLRPILASVRKENQEATSISWKLAERVMSNCATKLQPYLMDAVQSLGASLDDYAPVVMSICRNETDNIDDGKHLVTQMHTPDASIEENPRTDAASESLISGSTVAAGNDNILKGSSKKSQKCSEQSKIAETKIPDNVESKKAEDTLDTVPKKRGRKPNSLMNPDEGYEHYWIGKGRERSRLSNQNKSNDQETKFSPVSLRIEKVSLPTKVEKVSSGHAAEKHIQSKVEGVNENMTKKEENTRVRSRKPKVGKSRKDKTTAVSPVSPRVESLPTEEEKESPGHAEEKHIQSEDELVNENMKKMEEKARVRSRKSKIGMSRKDEGTKFSSVNSKVKKASLSAEVGKESSAHTEEKRIQVEDEVVNENTEMVKKAQARSRRSTVGKSRKDKATKFSSISPKVQRDTLTTEEESSADAEEKPLQSEDEVVNEHVKMMEEKTQSRAKKSKTGKCKDKAIHDPRCVISEEKVSVPSDYKEKLSVHLVMKLRVKSTNGDGSVVQKDVIVKSTDTDMDKNIHKSSTCEDSGSAKLDGDDYVEETPQAEATRRHAIVEKEVMSISSAGEELVGRRIKVWWPLDRMFYEGIVRSFDPVKKKHQVSYDDGDEEILNLKKQRYELIVADPLLVGDEEMDVPETEASSDILRKRKRKNMSESDKEEKTYSSTRRVRASTKRKSDVKSAKSSEKAANSSMLRKHVISDESMDEAGSVDNSTKGNDKKLIDLIKNSRLRINLKSKQNASGRE
The following text describes a protein:
Function:
Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKYIDSLQLIGLNSYLNSIDVGDALLMGELEAYSCKMAGSDKKIYRSLDKELEELSNTNSGAMNITNSNNNTNNNNNNNSNSGSSNNNNNNNNTLSVSMNSPSPTSNISVSPFGPMSNSTSRKTMIYLIQLLNLSFPDYDFTDSKPEQFQKEPSLNLVINSINANLAGYIKDYYLEFEAKLWSTLESEISLQKCEIYLYKPENGDPFTENGVLFSFNYFFYNKSLKKIIFFKCRYISKLQILNDDGSDVKDPLPDQEELDDYYREYYDGDTIDNMEMS
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVHPYLWVIIVGGIVSFLTGCGVGMNDLANSFGTTYGSRVLNLWQIVILASICEFVGAVSLGSEVTSTISGGIANPMTFANEPYVLMYGMMCALSATFIWLLFATMMSLPVSSTHSIAGAIIGFALVYGGFGAVSFAKKIDEFPYVTGVAPIIASWFISPMFAGAVAASLYALLRLVVLRPANSVNRALFALPLIVGVTFFLESFFVLFKGAKARLHWGPAKASWVAALIGLGAASISAACIPLLRRRVRLITERAERERAETGMNTAPEISGDAGAISENAAGVGAAVEGPVDTANRIVPPSSEPTSDSPTAKENPANNASGLTTPGVVDEALKFDVQIYDERVEYVFRYLQVFTAACASFAHGANDVSNAIAPFSAMYSIYINQQVVEENDVPLWILVLGGAGLVVGLATLGVGIMRLLGERITKITPSRGFSAELSVALVVSLCSAFGIPVSSTHCITGAVVAISIMDCGFRKVRWMMVGKMYLGWIFTLLITAAISALLFAQGIYAPSLTSQ
The following text describes a protein:
Function:
Disease resistance (R) protein that specifically recognizes the AvrRpt2 type III effector avirulence protein from Pseudomonas syringae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Acts via its interaction with RIN4, and probably triggers the plant resistance when RIN4 is degraded by AvrRpt2.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Not a peripheral membrane protein. Has the biochemical properties of an integral membrane protein without an obvious integral membrane primary structure.
Domain:
The LRR repeats probably act as specificity determinant of pathogen recognition; The coiled coil domain is essential for the resistance to AvrRpt2; the cultivars that do not display resistance showing specific variations in this region.
Sequence:
MDFISSLIVGCAQVLCESMNMAERRGHKTDLRQAITDLETAIGDLKAIRDDLTLRIQQDGLEGRSCSNRAREWLSAVQVTETKTALLLVRFRRREQRTRMRRRYLSCFGCADYKLCKKVSAILKSIGELRERSEAIKTDGGSIQVTCREIPIKSVVGNTTMMEQVLEFLSEEEERGIIGVYGPGGVGKTTLMQSINNELITKGHQYDVLIWVQMSREFGECTIQQAVGARLGLSWDEKETGENRALKIYRALRQKRFLLLLDDVWEEIDLEKTGVPRPDRENKCKVMFTTRSIALCNNMGAEYKLRVEFLEKKHAWELFCSKVWRKDLLESSSIRRLAEIIVSKCGGLPLALITLGGAMAHRETEEEWIHASEVLTRFPAEMKGMNYVFALLKFSYDNLESDLLRSCFLYCALFPEEHSIEIEQLVEYWVGEGFLTSSHGVNTIYKGYFLIGDLKAACLLETGDEKTQVKMHNVVRSFALWMASEQGTYKELILVEPSMGHTEAPKAENWRQALVISLLDNRIQTLPEKLICPKLTTLMLQQNSSLKKIPTGFFMHMPVLRVLDLSFTSITEIPLSIKYLVELYHLSMSGTKISVLPQELGNLRKLKHLDLQRTQFLQTIPRDAICWLSKLEVLNLYYSYAGWELQSFGEDEAEELGFADLEYLENLTTLGITVLSLETLKTLFEFGALHKHIQHLHVEECNELLYFNLPSLTNHGRNLRRLSIKSCHDLEYLVTPADFENDWLPSLEVLTLHSLHNLTRVWGNSVSQDCLRNIRCINISHCNKLKNVSWVQKLPKLEVIELFDCREIEELISEHESPSVEDPTLFPSLKTLRTRDLPELNSILPSRFSFQKVETLVITNCPRVKKLPFQERRTQMNLPTVYCEEKWWKALEKDQPNEELCYLPRFVPN
The following text describes a protein:
Function:
Transcriptional regulator which binds DNA consensus sequence 5'-CCTTAAC-3'. Plays a role in establishing and maintaining asymmetric cell fates in chemosensory AWC neurons during larval neuronal development. This is achieved by repressing the expression of multiple AWC (OFF) genes, including srsx-3 and hlh-11 in the AWC (ON) neuron. Activates expression of sox-2 in the AWC (ON) neuron.
Subcellular Localization:
Nucleus.
Sequence:
MSSDTKYKYAVVRIPETSVVDFFSLIVAKGYSDVSFVASLSQCNLRDDPNDDQPTTSSNSVKESINDDESNSENNKLSPPRRQSNPHSSLPAISSSTVKNEPTDSWTPSALSNDPTPDLLSATVPAELLTNLFAKTKSTEPKPQQLFGFQASGVDFDLSNNEWHENLRLPNGNGTEKYHPYGGNSKNDSPLQTRMKGWQREYIKEVIKDSHYPTEEELRDIEQKCDLSRKQILRFIAKRLTNPNRKPRVNHHDEKRKEQEERDSLADPDDDMINDNEAVTNLHHILNSLQETTA