lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Upon antigen recognition by the TCR, is recruited to lipid rafts.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R.
Sequence:
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
The following text describes a protein:
Function:
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subcellular Localization:
Membrane; Single-pass type III membrane protein.
Sequence:
MTELSANHGGSAKGTENPFEYDYETVRKGGLIFAGLAFVVGLLILLSKRFRCGGSKKHRQVNEDEL
The following text describes a protein:
Function:
Negative regulator of transcription elongation.
Sequence:
MADEPRRSGRSTKGQHKSLDMVNETPTKKTKAKAQPRDKPPKPSAEPTPAPSEEEEIIRCICGEYEEEEDIERDMICCDQCSAWQHNDCMGLTFAKGEVPDQYFCEQCKPEDHPVLMDKIARGEKPWLEVAERRRKEAEELKQARRKKGRRGGKRGRPSEPKEPKPEKSTPSRTPAPRASGTPAAEPPAPVIATPAPEKNSHSPEKPPSSSQKRKLSEQEVSTPESGPKTKQAKISPPAASPAPHVNQSPEDKEPVGQDTNQTPAADTTKTERLKTLEDITNPARRNAASALTKVFVDQISSALAGGSFKMSEGKTGEEVGQQLGISVEEALYQNLMGGGGEATSEAYKIQLRAILFNVKKNPSLRDRLLVGSLTPDALSRMSSQEMASEELQQKDAEIKREAERQHMIIQEQGPRIRRTHKGEELVEDDQTNVSTEPVFSNIPRRVTETDGSPAAQSPTSPSAKQPETDGHKVKTDATPAEPTPHDEHFPTRSHSPGAGQDQVFPEVATHISQPIPTGNVQADAEIDQLLKDDDEPESPPYSPKDHHDEGAVWHGRVVMNPVAEFSSFAKHVAGADLSGRIPWNDLIPSTLLIDGRIKIQSAGEYLCGLRFSQSTDVSVVAISSPDSSKDKSNFDKLFDYFQGRERYGVMGKHPLEAVRDTYLIPIEAGSTKKPEFIELLENNALEDPTPERLFLVVFAVKTGESNPPSVQPPSLHASMEPAASASPLTVTSGTPQQPFATPGPRHLLQYPQTPSPAFPGASHATAPYSQPQPQPQIQHQQPPPKATQYNSSLQPQLPTEPTGLPAAIQVLGGHANTPAIQELLQKAPTITVTQLNVVRDILVRRPQAAADYTTLMDELLGESTTRTNGSGTGSGNGHPPPQQQQPAQ
The following text describes a protein:
Function:
Catalyzes the NADPH- and oxygen-dependent oxidation of the monocyclic monoterpene ketones 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone. Is able to convert all enantiomers of these natural substrates with almost equal efficiency. Is thus involved in the conversion of the monocyclic monoterpene ketone intermediates formed in the degradation pathways of all stereoisomers of three different monocyclic monoterpenes, i.e. limonene, (dihydro)carveol and menthol, which likely make R.erythropolis able to grow on these compounds as the sole source of carbon and energy.
Miscellaneous:
MISCELLANEOUS: The 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one lactone obtained from 1-hydroxylimonen-2-one is unstable and undergoes a spontaneous rearrangement to 3-isopropenyl-6-oxoheptanoate.
Sequence:
MQTIPSTTETAADFDAVIXGAGFXGLYALHR
The following text describes a protein:
Function:
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission. Negatively regulates NLRP3-driven inflammation. Catalyzes NLRP3 palmitoylation, leading to its degradation via the chaperone-mediated autophagy (CMA) process.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MALWPPLNSGMLVRTGHTVLTWGITLVLFLHDTELRQWEEQGELLLPLTFLLLVLSSLLLYLAVSLMDPGYVTTQPQPQGEPKEEQAAMVPQAVPLRRCRHCLVLQPLRARHCRDCRRCVRRYDHHCPWMENCVGERNHPLFVAYLALQLVVLLWGLCLAWSGLQFFQPWGLWLRSTGLLFTTFLLLSFFALVVALLLASHLYLVARNTTTWEFISSHRIAYLRQRTSNPFDRGPTRNLAHFFCGWPSGPWETLSAEEEEEGSSQVV
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Golgi apparatus.
Sequence:
MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCYGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL
The following text describes a protein:
Function:
Catalyzes the site-selective attachment of phycocyanobilin (PCB) to 'Cys-82' in CpcB and 'Cys-83' in PecB. Also able to add PCB to ApcA1, ApcA2, ApcB, ApcD and ApcF, but not PecA. In vitro can be made to add phycoerythrobilin, a non-physiological substrate, to its target proteins (using genes from Fremyella diplosiphon PCC 7601). Binds PCB extremely rapidly, followed by a much slower phase of PCB transfer to the apo-acceptor protein. This suggests that the lyase has a chaperone-like function, and may serve to regulate the manner (possibly the conformation) in which the chromophore is attached to its target rather than to accelerate the rate.
Sequence:
MNIEEFFELSAGKWFSHRTSHHLAFKQSEDGKSDLVIESLAADHPEVIKLCELYEVPASAASCGARVSWNGTMEWDEEKHTGSTVLATVPDVDNPNEGRLLREMGYAEKAPVAGRYKMGDDGALTLTTEYETMWSEERLWFASPNLRMRVSVLKRFGGFSMASFTSEIRMGGSPAAAKAEEAANSASS
The following text describes a protein:
Function:
Microtubule-dependent motor that is probably involved in microtubule organization in the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localizes in the nucleus at the interphase and on the mitotic spindle during mitosis.
Sequence:
MEKRQLYSSQSQSQPLNIITNTINSRPSLLRKPASSSSQSNDRISYPPSTDSKFIQQQYHQPLLTNTDIKLEDIESSSSNNNPLKNSINNVSMQISQLNSSHHSRALLMQKRNNPTTNIRPTVKKKLDDTHKPLTSNFKKPITPISKLNTNMNNNNINNKNNNININSNNSSNSNNNILSPVQNNTISPNSNLLNSSIKFEKSNFFSTMYSSPTTITTTSTTLNNDNNNNISISSSCSNNSSFDLQQQHALHERMNKIDQFTQTVRGNLQSQFDNISEQLKPPRLSLSIQDIKTRLDFEEKNKEVEKIKLELKNVLQSLKEKEKELMEAHYKVSQVSVLKDNMERDLQQSNQMILDLQHEIRSSSLKAIQVDEKFNNMKDVTKDLDDEILRLNQLVRERDTEIESLRKENRELLEKSRSDEKVRRKLHNTIQELKGNIRVFCRIRPDFSSGQGANGSVFNIPAGTDNLVEVKSPTIDSFNGEASIKKSTFTFDRVFGPSSTQELVFEDISQLVQSSLDGYNTCIFTYGQTGSGKTHSILGDLKVPSQRGMIPRTVEKIFSSIQDLTEKGWTYQIECFFLEIYNETINDLLNTTTTTTGGNSKSNEIKYEIKHNPDTNVTTVTNMTVVPVTHPSQVYELLNLANKNRSVAKTLCNERSSRSHTVFQLKLIGYNQQSSERTQGLLNLIDLAGSERVSRSGVEGKQLKETQAINKSLSSLGDVISALANKEQHIPYRNSKLTFLLQNSIGGNSKTLMFVNISPELKDLQESTSSLRFAAKVNSCELGAARKQKII
The following text describes a protein:
Function:
Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.
Subcellular Localization:
Fimbrium.
Sequence:
MKHKLMTSTIASLMFVAGAAVAADPTPVSVSGGTIHFEGKLVNAACAVSTKSADQTVTLGQYRTASFTAIGNTTAQVPFSIVLNDCDPKVAANAAVAFSGQADNTNPNLLAVSSADNSTTATGVGIEILDNTSSPLKPDGATFSAKQSLVEGTNTLRFTARYKATAAATTPGQANADATFIMKYE
The following text describes a protein:
Function:
Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes mainly in the cytoplasm.
Sequence:
MIGSPDLVAFTKETDFSEITTDSSVLPEDLSVPMYPYTGDATPWSKISSAKLKKDFILISEFSEQVGPQPLLTVPLETKACGTFDLNYFSLRIMSVDYQTSLAGSPGYGSFKLNFVEDSKVVLADSREGVFAYVHHLTLYDLEARGFVRPLCLAYVSSDENKIIQQFQRISTEFNKVSECLKTGNRKNFANELEVKLRDLEYTRVVLQKELNTVSVKCSSEREPILNGVHSFERNADEVKLNEKSSHTDEISPQEKDGCGNSRKVEVKLENENRSHFEHEQYGKQRKDKPDKTSCPMPLANKNDELASVEKLIQDYKSLLKQVTCYPTRKLRDSEYSPYEPDDLPQSFDLDLDSQFAGPMLECSVFTYTNTPSQTLQQINSTSSSRFDKRLKTLEELCDDYFYQQALQQLYSIERTFRGDACYLYTQQLCRNLLRNLKSTNFLFEDPCDLDDDVGLQIGQSTIQQPSFLPAPSFLSGPVSLESYASCVEMVPIKLELGGSSQSQVQHSTLNTPSKDNRPQVADKSPAEVEMKGEIISAPDCQGNVESVSNLMKTSISSGDSIEVLGTERSFRSQGANTLVETAMHRPPPLSSATALEGLKQGRVPTRRTCSEDSIEVLCITESISPDELRASYPCAIDEESPEQETDEKNSSQYQEDNNEKSIYVQGKISADHENACLKKLHPSVTVTPPDCPLTLEETSFQDSCQATESATMLLLDEPSRMVPDDLSDCFSYRSTTASTTSECTFPACLPKDKREGGTRRRRGRVGRAALQFMRQFPFAVHAVFSLLSGRTLVVLGSEEAAVRRLVTALSVYLPHLTKYKDSIQPWTSTPLQLTDLLNWKLIGFDRMCSFNPSSLPHCLDHYSRYLSILDVDQKTLHCPTYSGSLINLLVEPKSHFKRGNTYFTFAQSVQSKLVTKAFLLTFSHGHPSPSRPQGSSGTECFLSELHTDDKKILRYLSELIKLHFMEVTPNVLLFSYTTTSIFKL
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MGTRSDSGGGAYTTPTEWKLWNQTKLSQSQFERLTAERLDAESKRLRDDVGTRVTSSRREVSQQFSTRIRDLQYWSTNLESKTSEVGTEIDALLQCQAQLQRMHHACGDPIAVVEQCLQLRERRSHVDRCLDEVQSSLHDELRTLRQGEMVLGRTVIEAAEQIRLLRSAKYQLDRDLADKGKASEIDSTTVGLADSVVGDGRTPRLLSDLVHSSQVNATVHFPWSTPGADLGGNDRNAGAITKANRQTTPTEWQSFTERNIQEASEQVHRSLQLRVTAMSVMQDIIRDTRSHANQVDQLFHDVIDRTRKALGALKSEHSAVCQQIQETEETASGLRAAIGAQDAPLGSAIQQLARRTARPNVEFCRDSVQNCLETRVDVVRTSLRQLQEKLSQADASLRRLRQSKFDLEQEIAVKEATLRIDAEHCMNALRRNMVLPQP
The following text describes a protein:
Function:
RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly.
Sequence:
MLMQLPRLTNSLRDPFDVDQAYLQRKIILQNRLKHRNTANSLNESELARKIVYRWEEASTEVTQAYKQFIGGVVDLIDGEVPSEEFREVALTAYRLFGGPGPVEEDNDDSSILKRKSELQKLIGHAVLDANIQRVATLAQRLSSLQPTSHESALVLESHVNGSDRDLEFGADLAFQTPARFLVDITLEDEEDAETTGPSLFQDGWHDHNDYGHNHSAADGGKFNLSWLRDACNQIVRESTSQLSQDDLAMAICRVLDSNKPGEEIAGDLLDLVGDSAFEIVQDLISHRKELVDAIRHGWSVLKSDMTVSSIQSRMPSYGTQVTVQTESERQIDKLRRKEEKRHRRGTEHGVDNDASAASFSSLLQASERKNLLDDLIGSGAGSHSLSITALPQGTIRKHYKGYEEVVIPPTPTAQMKPGEKLIEIKELDDFAQAAFHGYKSLNRIQSRIFQTVYYTNENILVCAPTGAGKTNIAMISILHEIGQHFKDGYLHKDEFKIVYVAPMKALAAEVTTTFSRRLSPLNMVVRELTGDMQLSKNELEETQMIVTTPEKWDVITRKSSDMSLSMLVKLLIIDEVHLLNDDRGPVIEALVARTLRQVESTQTMIRIVGLSATLPNYLEVAQFLRVNPDTGLFFFDSSYRPVPLAQQYIGISEPNFAARNELLNEICYGKVVDSLRQGHQAMVFVHSRKDTAKTAAKLVEIARKYSDLELFKNDAHPQFSLIKKEVVKSRNKDVVELFEFAVGIHHAGMLRADRVLTEQLFSDGLLKVLVCTATLAWGVNLPAHTVVIKGTQLYDPKAGGWRDLGMLDVMQIFGRAGRPQFDKSGEGIIITSHDKLAYYLRLLTSQLPIESQFISSLKDNLNAEVALGTVTNVKEACAWLGYTYLFIRMRQNPLAYGIGWDEVIADPSLSLKQRSFITDAARALDKAKMMRFDEKSGNFYCTELGRIASHFYIQYSSVETYNEMLRRHMNDSEVIDMVAHSSEFENIVLREEEQNELEMLLRMACPLEVRGGPSNKHGKISILIQLYISRGSIDSFSLVSDAAYISASLARIMRALFEICLRRGWSEMSLFMLEYCKAVDRQIWPHQHPLRQFDKDLSAEILRKLEERGADLDRLQEMEEKDIGALIRYPHGGKLVKQYLGYFPWIQLSATVSPITRTVLKVDLLITPEFTWKDRFHGASQRWWIVVEDSENDHIYHSELFTLTKRMARADPQKLTFTVPIFEPHPPQYYIRAVSDSWLHAEALYTISFHNLALPEARTTHTELLDLKPLPVSSLGNVIYIAPLKAIVRERMNDWRKRLVSQLGKEMVEMTGDYTPDLMALLSADIIISTPEKWDGISRNWHTRSYVTKVGLMILDEIHLLGADRGPILEVIVSRMRYISSQTERAVRFVGLSTALANAGDLSDWLGVGEMGLFNFKPSVRPVPLEVHIQGYPGKYYCPRMNSMNKPAYAAICTHSPTKPVLIFVSSRRQTRLTALDLIQFAAADEHPRQFLSMPEDALQMVLSQVTDQNLRHTLQFGIGLHHAGLNDKDRSLVEELFANNKIQVLVCTSTLAWGVNLPAHLVIIKGTEYYDGKAKRYVDFPITDILQMMGRAGRPQYDQHGKAVILVHEPKKSFYKKFLYEPFPVESSLKEHLHDHINAEIVTGTICHKEDAVHYLTWTYLFRRLMVNPAYYGLENAEPETLSSYMSRLVQNTFEDLEDSGCIKLNEDNVESMMLGTIASQYYLSYMTVSMFGSNIGPDTSLEVFLHILSGASEYDELPVRHNEENYNEALSQRVRYMVNKNQLDDPHVKANLLFQAHFSQLELPISDYVTDLKSVLDQSIRIIQAMIDICANSGWLSSSLTCMRLLQMVMQGLWFDKDSSLWMLPCMNADLLSSLSKQGISSVQHLLDLPKATLQAMIGSFPASKLYQDLHHFPCIKTKLKLQKKDADGTKSLSLNIKLERTNSRKSSRAFIPRFPKIKDEAWWLVLGNTSTSELYALKRVSFSDRLVTRMDLPSSFTTVQGTKLMLISDCYLGFEKEYCIEEIVKSQEMETGI
The following text describes a protein:
Function:
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
Miscellaneous:
MISCELLANEOUS: 'Bric-a-brac' means 'jumble' in French (referring to the mutant ovary phenotype).
Subcellular Localization:
Nucleus.
Sequence:
MASAQAETNVGLASEQGPVAQRQRKGTGSGADSPKSNRSSPTQQEEKRIKSEDRTSPTGGAKDEDKESQGHAVAGGGGSSPVSSPQGRSSSVASPSSSSQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTLLAETPCQHPIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLADVTHMEAATAAAAAASSERMPSSPKESTSTSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSPLERQQGRNVRKRRWPSADTIFNPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPPPKPPMSSGSTVGATRRLETAIHALDMPSPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAGSAHHPASPAGDSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGGGAGGVGSGGGSSLADDLEIKPGIAEMIREEERAKMMENSHAWMGATGSTLAADSYQYQLQSMWQKCWNTNQNLMHHMRFRERGPLKSWRPETMAEAIFSVLKEGLSLSQAARKYDIPYPTFVLYANRVHNMLGPSIDGGPDLRPKGRGRPQRILLGIWPDEHIKGVIKTVVFRDTKDIKDESLAAHMPPYGRHSPAFPLQDLPLSYPGASGALAGAPSSMACPNGSGPQTGVGVAGEQHMSQETAAAVAAVAHNIRQQMQMAAVPPGLFNLPPHPGVGGGVGNVPGAAGGRASISPALSSGSGPRHAPSPCGPAGLLPNLPPSMAVALHHQQQQQAAHHHMQQLHLQQQQAHLHHHQQQQQQQQQQHHQGGHQVAHKSGFGASSSSSASSSSMGQHHAPKAKSSPLRSETPRLHSPLGDLGLDMASYKREFSPSRLFAEDLAELVGASVSSSSSSAAAATAPPERSAGAASAATGADAPSSSSSGGIKVEPITTTSE
The following text describes a protein:
Function:
Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throughout hyphal growth. Moreover CDC28-HGC1 phosphorylation of EFG1 represses cell separation genes during hyphal growth. Also partially controls SEP7 phosphorylation status and subsequent septin ring dynamics. Required for virulence and especially mediates dynamic adhesion to endothelium of blood vessels during circulation.
Sequence:
MINITKPLTPKSISQQKQQQQHPYKNISTTKSNNNPQASGSKSFVQEKYPSQLYESEIKIHNQSLAEYDLDIYDIMVNLIETNKPNLSLYKQQPYLTFTIRLKLIDFLLKMSIRLKILPFVFFKAVKIFDRYCSKRIVLLDQSQLIITTCLWIASKVMGGNNHFVNINNLDKIGHENFRTINDLGYGCGGKYLGPTERFRLPKLHELVKLCGAKCKYDQGMFKQMEVHVLNTLEWSLNDPSIEEFIIDSHEFNVININNNNEYEQTITTNDESANANANDGNEFFKIKEFLSYAALYSHDLIDTNIIELGQVIMDLINETFQLQPFDKHYQTILNCDSDHPIRFDMQRYKHIKKAVIKSVLNASDFMMKVFHSKGPQFIYQQFNLQYKLNYTTNSIIGGFGNSGYSPTTTTTTTTSDNISTTPTSSTGSTTPVSSYIGYANSRSSSVSSTSSVASSSNANTPSSSCSTTSTTPLGMTPHKRQKNYSNYSNYSNYSNSSTSLGLTNNNNNNTTISPVDSTTINSHTKNSSQLNYQYHNGGSNNNNHHHHHKPSLSVSIPPPQMHSHHHSSTVYQMVTPPNSANKNSNKSNSANNNNTTTIATTTTTTTNNNNNSQLPAPHQLSYNNYFNSPNMQPPPPMKYTPGRKQQQQQNQGQNQQQPLQLYQGDNNNNGTNTNSKFNSIAGSRAVSSSSSSAVSIASSISTNNYDKYDDDDDDDNSNDLFSSSRRFMNYSNYSSSTINGSVMSGVINNNSGNGKGNGNGGSGTPISENDSPIYTKTRLCNMIH
The following text describes a protein:
Function:
Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSASGIFSVMSASPSRSSSPAVSANPNHQIPFNSAPVQHAPSPLGFGFGFGSSFGGNNVGVYSSASPSFGFGSASTSASLTAPSPTRRSDAKRRRDLDEDDDLDDEDEDMAHTRSSRLASDPFALSHEHKRVVLPKRIRAGLGFGLMNTEASQAASATTSAFSPSSLVHPQSNTSYTLSPSSSKRPALGLSNRVGMSGIDVDIGKMLASMDKPSLLSMLSSLLMQSKDASLPAQILSLLPAPSLDSVESSLDELEKAIRSAIPFVADGSSVRHEYTWSRLRAPIASFVDAALGYLPFFVTELDSDREQRLRERDPRLQADREEVHPATTFTFLLMITSRVLRLEALLPSVTKSSLAFNLFTASAQPNFGLGGSGACTASSASKLGGVGATDAYGKHSNLAYMLGTEFASPSSPDALMTVLMPAVLKQWTTLLHRLDKAVNGDARMFSQELVLNWARALEATGTQGSVKKDHQKQEELLIRKAMDEVRNRLERDLAWLVGGSQYHGVHKKDKRTRAASMSDEEEL
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.
Miscellaneous:
MISCELLANEOUS: Present with 4260 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MNDEINEPPPNICEQCLGDEANIRMTKIPQGSECKICTLPFTLYHFKTSKRSNNIIKTLICVRCATQRNICQCCMLDSRWHIPIQLRDHLISLVNEENVMTEEAKNDMMKRFLSLKNVKLGGAQITSDPSEADNIVDKLKNILLRATSDGPSTPLIKNTTALYKNEKGANEVKNLEKYASVDISHILKKLPLNESFLKNPSTKSFFLYNIDASIPEWKITDTVSQLLGIKKWKDGNSLSLIVNHKAKCGGLRFQSSELGERFVSKISETLVTPKGLKRGVLLIDRFRIFIIPWSSGFSAASFGTNTAENIKLSLSLNKLIQLELGLSFPTKSTDNAKNDKKKTSKKVHKDRSKKSKPRANKLTI
The following text describes a protein:
Function:
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MRLSPRSLCAAVRAAWRESFPLEGRDVARWFPGHMAKGLKKMQSSLRLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLKEQQKIIQHLEREGIKHVVFTNCVKDENVKQVIPTVTELVGSSYRYHRGEHVEYCIMVIGVPNVGKSSLINSLRRQHLRKGKATRVGGEPGITRAVMSRIQVCERPLMFLLDTPGVLAPRIPSVETGLKLALCGTVLDHLVGEETLADFLLYTLNRHQLSGYVQHYGLGEACDDIASVLKRVAVKLRKTQKVKVLTGTGNVNVIQPDYPAAARDFLRAFRSGLLGPVMLDRDLLQGRSAEES
The following text describes a protein:
Function:
Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects; Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.
Sequence:
MDIRRVAVLGAGVSGLAAIKTCLEEGLQPVCFDKARELEEYWYHCYVFQGESECYRRRRNHGHNEGSCARSWGLRSCCDQNLSRGRLQPVCFEKARELGGLWVYNDEVGPDPTGPAGIYKGLITNVSKEMMSFSDFSYPRHVPPFLTSDDVLQYLQNYAENFNLLKHIHFNTTVIEVTKAVDFKETGKWNVCTQAQGEPPKTETFDAVMMCSGIYSSGKIPDYPGLNEFKGQILHSGQFRGGEEFVDKTIVVVGSSHSAGDVAVLSSNHAKKVYLSLRDGAWIVSRITGKQPTDVYINRRWNEAIPAWIYHPLLKLKMESLQDWKTLGIQSSTHPVKSSFMMNDELPVKIMSGRVVVRSGLQRFEGSRVIFDDDSYLEDVDCVVFATGYNHRIYMEDDVISGSTSQLELYLHVIPPRLEHPTMAAIGYIVTRGTLGPSAELQSRYAVKVFKKELQLPSRSEMLADIKKRRDGVMQQYNQDTPKIHPTKYNDELAQAIGALPSFWSLLLSDPKLAYHFYFGPVYPTWYRLMGSHSRPDARQRILQSGADMVHGITLKTVRPRAQKELQRTRIIPMRLVALCFISFLLAVLLWT
The following text describes a protein:
Function:
Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation.
Miscellaneous:
MISCELLANEOUS: TibA-mediated aggregation is blocked upon capsule expression and fimbriation and is sensitive to pH extremes.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Domain:
The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space (By similarity). Then, insertion of the C-terminal translocator domain (or beta-domain) in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface (By similarity). Unlike autotransporter AIDA-I, appears that there is no cleavage between the N-terminus and the C-terminus translocator domain (Probable).
Sequence:
MNKVYNTVWNESTGTWVVTSELTRKGGLRPRQIKRTVLAGLIAGLLMPSMPALAAAYDNQTIGRGETSKSMHLSAGDTAKNTTINSGGKQYVSSGGSATSTTINIGGVQHVSSGGSATSSTINSGGHQHVSSGGSATNTTVNNGGRQTVFSGGSAMGTIINSGGDQYVISGGSATSASVTSGARQFVSSGGIVKATSVNSGGRQYVRDGGSATDTVLNNTGRQFVSSGGSAAKTTINSGGGMYLYGGSATGTSIYNGGRQYVSSGGSATNTTVYSGGRQHVYIDGNVTETTITSGGMLQVEAGGSASKVIQNSGGAVITNTSAAVSGTNDNGSFSIAGGSAVNMLLENGGYLTVFDGHQASDTMVGSDGTLDVRSGGVLYGTTTLTDKGALVGDVVTNEGNLYYLNNSTATFTGTLTGTGTLTQEGGNTRFSGLLSQDGGIFLQSGGAMTMDALQAKANVTTQSGTTLTLDNGTILTGNVAGDSTGAGDMAVKGASVWHLDGDSTVGALTLDNGTVDFRPSTTTRMTPAFQAVSLALGSLSGSGTFQMNTDIASHTGDMLNVAGNASGNFVLDIKNTGLEPVSAGAPLQVVQTGGGDAAFTLKGGKVDAGTWEYGLSKENTNWYLKADTPPPVTPPTNPDADNPDAGNPDAGNPDAGNPDAGNPDAGKPGTGKPDAGTSSSPVRRTTKSVDAVLGMATAPAYVFNSELDNLRFRHGDVMQNTRAPGGVWGRYTGSDNRISGGASSGYTLTQNGFETGADMVFDLSDSSLAVGTFFSYSDNSIKHARGGKSNVDSSGGGLYATWFDNDGYYVDGVLKYNRFNNELRTWMSDGTAVKGDYSQNGFGGSLEAGRTFSLNENAWAQPYVRTTAFRADKKEIRLNNGMKASIGATKSLQAEAGLKLGMTLDVAGKEVKPYLSAAVSHEFSDNNKVRINDTYDFRNDISGTTGKYGLGVNAQLTPNAGVWAEARYENGKQTESPITGGVGFRINF
The following text describes a protein:
Function:
Protein that assembles into highly ordered structures and provides a specific site for viral DNA replication. Probably anchors the viral DNA replisome to the host membrane.
Subcellular Localization:
Host membrane; Peripheral membrane protein.
Domain:
The hydrophobic C-terminus is involved in the association with the host membrane. The coiled coil region is involved assembly into protofilament sheet structures.
Sequence:
MGKIFDQEKRLEGTWKNSKWGNQGIIAPVDGDLKMIDLELEKKMTKLEHENKLMKNALYELSRMENNDYATWVIKVLFGGAPHGAK