lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a slow and tight inhibitor of host neutrophil elastase (ELANE). Inhibits host proteinase 3 (PRTN3) and chymotrypsin. Does not inhibit other host proteases involved in coagulation or inflammation, such as cathepsin G (CTSG), trypsin, chymase, matriptase, beta-tryptase, kallikrein, urokinase-type plasminogen activator (PLAU), coagulation factors Xa (F10), XIa (F11), XIIa (F12), plasmin (PLG), thrombin (F2) and tissue-type plasminogen activator (PLAT). Inhibits host neutrophil chemotaxis induced by N-formylmethionine-leucyl-phenylalanine (fMLP) in vitro. Inhibits ELANE-mediated potentiation of platelet aggregation induced by CTSG in the host. Does not affect CTSG- or collagen-induced platelet aggregation. Blocks cleavage of tissue factor pathway inhibitor (TFPI) by ELANE in the host. Inhibits neutrophil-induced coagulation in the host by interfering with neutrophil extracellular traps (NET) formation. Exhibits anti-inflammatory activity. Reduces ischemia-induced activation of MAPK and NF-kappa-B pathways in the host. Decreases CCL2 and IL8 production in IL4- or lipopolysaccharide (LPS)-stimulated host epithelial cells. Reduces caspase-3 (CASP3)-dependent apoptosis in damaged host tissues.
Miscellaneous:
MISCELLANEOUS: Reduces inflammation and neutrophil accumulation in a mouse model of acute inflammation. Prevents thrombus formation in FeCl(3)-induced carotid artery thrombosis model in mice without impairing hemostasis. Protects mice from experimental ischemic stroke by reducing local thrombus formation, blood-brain barrier damage and inflammatory responses in brain.
Subcellular Localization:
Secreted.
Sequence:
MKMRVHLLAVSVLLVVLALQTTPAEADINSEMATCACQLIYRPVCASNNESYSNECVLKCASETPTGRSIGLHKVKDGNCNGEF
The following text describes a protein:
Function:
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by nbn following phosphorylation, and promotes the endonuclease of mre11 to clear protein-DNA adducts and generate clean double-strand break ends.
Miscellaneous:
MISCELLANEOUS: Binds one Zn(2+) atom per dimer. Zn(2+)-binding is not required for homotetramerization.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with sites of DNA damage in S/G2 phase. Recruited to DSBs by the MRE11-RAD50-NBN (MRN) complex following phosphorylation.
Sequence:
MSITPADLSPASSSDHREKLQELLTAVRDLHDTALQELQAKIAKLKKERCLDAQKLSEFHSKNQHLREQQKIQQEKIRQLEDRLRSGPCDRCTVKEKQIKKTNTELEDNNQRNLSVISELEAERKTLTDENRRLSLELERLRRSGSPQNTSSEAEEGMIPDSPLRPLSLPVASKMKRRKEQNHVRYTETPLSLSHPESRQREQSVAFGCNGKGVLVAETCEMDATSVAERDNKRHFRIVVPETCRPDVYPEQVDDVDDDDLHIPSHTEQNQKPELRDCTNILIAGQNDDSPLILRCRPLASQDHQSSIDDVLRTPANSSTCVLTKGKRKHSNGAKKDREISDCRLDADETDIKGIIFASTPANGRLQSKNQETSEIETTQDSKKKCLDGHTPRKSLVQNHHAPFPYDQSWSVDPGADLGQYDTESSPQPEHQARTDLETLDTDCTFVSHSLLLRGQKTTGQSQTTGIGQKANDSLADIFDKTGYGEYESCPQDDSIDLKQDSVYEEEREEDDPEEKPEAAVVFRRPADRKPLVSDSDKSSRNKSFACVEVVRKKDERRKLKGHYCKECEVYYADLPEEEREKKLTSCSRHRYRYIPPSTPENFWEVGFPSTQTCVERGYIKEDEQPDVRIRRRRPYLAMFSPKAKSQKKKH
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSGRKIAAATVQNRTQTPFWNWLKQKLLASDRLPITPPPGIAGPDGKAVYQNPLRFPNTQSARPCSAELPALPGGVHHKLADNYYLTRDGRRNVDAPKVLYSSGEFVGGEKAQPAQVNQGVATNFGLTAPTPGFGAEWSRSKQNELASQQKNTEFEYLQRFDKFTKSA
The following text describes a protein:
Function:
Electron transfer protein; may also function as the membrane anchor for the GlpAB dimer.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MVGDSRLTRDNSFESCIKCTVCTTYCPVAKVNPLYPGPKQAGPDGERLRLKDPALYDDALKYCTNCKRCEVACPSDVKIGDIIQRAKASHSTNKPKLRDAILSHTDIMGTLSTPFAPVINAVTGLKPVRVLLDKALKIDHRRELPKYSFGTFRRWYRKQAEKQQQYTEQVAFFHGCFVNYNHPQLGKDLVSVFNAMNIGVQLLKREKCCGVPLIVNGFIEQAKKQARVNLESLTDTVIGRDIPVVATSSSCTFTLRDEYPHLLDVDTTPVRDKVELATRYLYRLLDQGRELPLKPLFSLNPLLASQEAPLRIAYHTPCHMEKMGWTAYTLALLQRIPGVELVVLDSQCCGIAGTYGFKSENYATSQGIGASLFQQIEDSGVDLVITDCETCKWQIEMSTSKKCEHPITLLARALA
The following text describes a protein:
Function:
Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLFIIRARACGGDARSWKQPDQLHPILFTNLRLPLQLIASSAGGATDHNVDNTTGMLQEWLAAVGRDYATVVWKSEDEARSYPDEQGPKHWTRERHQFLMELKQEALAFARDWGADYILFADTDNILTNNQTLRLLIDRQLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRQGCFRVPMVHSTFLVSLQTEETARLAFYPPHPNYTWPFDDIIVFAYACQAAGVSVHVCNDHRYGYMNVGVKPHQGLEEEKTNFIHLILEALVDGPPMMASAHVSRPPKKPSKMGFDEVFVISLARRPQRRARMLSSLWEMEISARVVDAVDGRTLNSSILKHLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVAKGLARVVVFEDDVRFEDNFRKRLERLMEDVLTQKLSWDLIYLGRKQVNPEEEVAVEGLPGLVVAGYSYWTLAYTLSLAGARKLLASQPLHRMLPVDEFLPVMFDRHPNDQYKAHFWPRDLQAFSARPLLASPTHYAGDTEWLSDTETSSPWDDDSGRLISWTGSQKTLRGPYLHLAGSSGHSLHPHPRDEL
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell inner membrane. Cell membrane; Single-pass membrane protein.
Sequence:
MRTPIALSLALCLSLFPSFASAEEAAPEGEGANKPVYVDLTPALVGNYGSGPRLQYYKADIALQVADKDAATKVEHHEPLIRNQLIMLFAQQTDQSLGTVEAKESLRQEALKQVQQTLEQEEGKPLVTDLLFNNLIVQP
The following text describes a protein:
Function:
Catalyses the transfer of galactose onto proteins or lipids.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MYCLARINSRRSFYIFILCTTMVTVTWFHQGPWFQNVYLYMQSNTELASSTSGENTAILRALHPIMTSLNWTRNRKSIGALKIKEHTEALKPCLSSSEIPKVRIDPRKNKTTLARVNAEIFGSMVRKVRHAAGTANKSLPSILMKRRSIQKAASSIDQTISKMNLAVDVDDYRVLPGGHWIPLSCRPLWKVAIVVGFRNRFQHLPIFLRHIVPLLKRQKLEFSIFISEQRNNLLFNKAMVMNIGFIEAMEFNDFDCVVFHDVDHLAMNVRNYYGCENMPKHFESGEPKWNWKLPYQELFGGAVGVTTSQFVEINGFPNVYWGWGGEDDDFYNRVVANGFKPSRPEGEIGYFDTIEHNSKDSSRLNIAKFCLQKQCAERMSTDGLSNLKYEPPTIELHPLYTNISVNIQRLPWNPKWKRCDTLDTMYSL
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MENNQLSGQEAIFGGQYGSTLQVVSGDSSEEHQKLVEFLVEEDDTSVTESEEEYEIANIEDEVETEGVNAIEANNENEKKDEFSIGMKFSSDETAHIAYCKYACNHGFNGFDTHLLRLQPPSPSSLSNGFLPQRQGVTNLKVPNFRPRSSPSSPPMLKLFSSSTASRAHHHLSPAIRPGASPFFKALSHLTGLNRRSNSLGGRRVFFCSGNASDAAAAAAAEAEAKAAESDSDGSDAKSSSAIVPTNPRPEDCLTVLALPVAHRPLFPGFYMPIYVKDPKVLAALQESRRRQAPYAGAFLLKDDPSTDSSSSADVEKNINELKGKDLLKRLHEVGTLAQISSIQGDQVILVGHRRLRITEMVSEEPLTVKVDHLKDKPFDMDDDVIKATSFEVISTLRDVLKTSSLWRDHVQTYTQHIGEFTYPRLADFGAAICGANRHQAQEVLEELDVHKRLRLTLELMKKEREISKIQETIAKAIEEKISGEQRRYLLNEQLKAIKKELGVETDDKSALSEKFKERIDPNKEKIPAHVLQVIEEELTKLQLLEASSSEFNVTRNYLDWLTILPWGNYSDENFDVVRAQQILDEDHYGLSDVKERILEFIAVGRLRGTSQGKIICLSGPPGVGKTSIGRSIARALNRKFFRFSVGGLADVAEIKGHRRTYVGAMPGKMVQCLKSVGTANPLVLIDEIDKLGRGHAGDPASALLELLDPEQNANFLDHYLDVTIDLSKVLFVCTANVIDMIPNPLLDRMEVISIAGYITDEKVHIARDYLEKTARGDCGIKPEQVEVSDAALLSLIENYCREAGVRNLQKQIEKIYRKIALKLVREGVVPEEPAVAVDAEEAEIVTKLDVESTENHVVEESPAPAAKEPKEEAQNEKKAVEKVMIDESNLADYVGKPVFHAEKIYEPTPVGVVMGLAWTSMGGSTLYIETTVVEEGEGKGCLNVTGQLGDVMKESAQIAHTVARKIMLEKEPENQFFANSKLHLHVPAGATPKDGPSAGCTMITSLLSLAMKKPVQKDLAMTGEVTLTGRILPIGGVKEKTIAARRSQVKTIIFPEANRRDFDELAENVKEGLDVHFVDDYGKIFDLAFGYDKQQD
The following text describes a protein:
Function:
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MHALHQTLLPSSSIHHSLFLPHFTPSTIYPLPKPPAALDTLDVKVIGNLVVAGAEVLRVFEIREESVPIIENVKLEEDVAEGEKDVQMEEVGDGFFDDGHAERAPLKYQTTRRLHLLTQHELNGTITGLAATRTLESTIDGLDRLIVSFKDAKMALLEWSRGDIATVSLHTYERCSQMNTGDLQSYVPLLRTDPLSRLAVLTLPEDSLAVLPLIQEQSELDPLSEGFSRDAPYSPSFVLSLSDMSITIKNIQDLLFLPGFHSPTIALLFSPMHTWSGRLQTVKDTFCLEIRTFDLSSGTSYPLLTSVSGLPSDSLYLVACPSELGGIVLVTSTGIVHVDQGGRVTAACVNAWWSRITSLKCSMASVSQKLTLEGSRCVFVTPHDMLLVLQNGAVHQVRFSMEGRAVGVIEVLDKGCVVPPPSDLTVAGDGAVFVGSAEGDSWLAKVNVVRQVVERSEKKKDEMEVDWDEDLYGDINDAALDEKAQELFGPAAITLSPYDILTGVGKIMDIEFGIAASDQGLRTYPQLVAVSGGSRNSTINVFRRGIPITKRRRFNELLNAEGVWFLPIDRQTGQKFKDIPEAERATILLSSEGNATRVFALFSKPTPQQIGRLDGKTLSAAPFFQRSCILRVSPLEVVLLDNNGKIIQTVCPRGDGPKIVNASISDPFVIIRRADDSVTFFVGDTVARTVAEAPIVSEGESPVCQAVEVFTDTTGVYRTFEPSKSESSEPISHQIDSENKPNITNGINGTTARSARQTQLTPQQIKRLQEQEPAITTEAPSMETAINSPHGTQWLALVTRGGELQIRSLPDLQIVLQSEGLASSAPSFTDDLGENPGYVLGEKREEGEEEDEIIQMVFCPIGKGTVRQHLLALHHSGRLNAYEAQPRFTVDASSHSRRSLAVRFRKVHTQLLPISGGVGTTNGNARLPYTIVPFNNIEGLTGAFITGEKPHWIISSEAHPLRAFALKQAAMAFGKTTHLGGKGEYFIRIEDGSFICYLPPTLNTDFAIPCDRYQMERAYTNITFDPTSAHYVGAASIEVPFQAYDEEGEIQLGPDGPDLIPPTNQRSTLELFSQGSDPWKVIDGYEFDQNEEVMSMESVNLESPGAPGGYRDFIAVGTGFNFGEDRATRGNTYIFEILQTVGPQGGGGPGSVPGWKLVKRTKDPARHPVNAVNHINGYLLNTNGPKLYVKGLDYDSQLMGLAFLDIQLYATTVKVFKNFMLIGDLCKSFWFVSLQEDPYKFTTISKDLQHVSVVTADFLVHDGQVTFISSDRNGDMRMLDFDPTDPDSLNGERLMLRTEYHAGSAATVSKVIARRKTAEEEFAPQTQIIYATADGALTTVVSVKDARFKRLQLVSDQLVRNAQHVAGLNPRAFRTVRNDLLPRPLSKGILDGQLLNQFALQPIGRQKEMMRQIGTDAVTVASDLQALGGFW
The following text describes a protein:
Function:
Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose-1-phosphate, or fructose-6-phosphate.
Sequence:
MRFLAYFGHLNIDVLISVDSIPREGSVNVKDLRPRFGGTAGNFAIVAQKFRIPFDLYSAVGMKTHREYLAMIESMGINTGHVEKFEDESGPICYIATDGKKQVSFMHQGAMEKWKPQLADEYEYVHFSTGPNYLDMAKSIRSKIIFDPSQEIHKYSKDELKKFHEISYMSIFNDHEYRVFREMTGLSSPKVTTIVTNGERGSSLFMDGKKYDFPAIPSSGDTVGAGDSFRAGLYLALYNRRSIEKGMIYGTIIAHHVIDDGIENFSLNMEDLERETENYRRMFTKRS
The following text describes a protein:
Function:
Required for nuclear division. Could function in the mitotic spindle.
Subcellular Localization:
Nucleus.
Sequence:
MAVTSFPADSLASMESVKQTVRSTSTCSAATVLSLQTLFRSAGEMETTLRRTARGTKATATNATASSRAKTTRTKSTSTSTTRTKTPAQDVSTFTSTSASLADTRLSNQEKLVLATEVFNSTLKTLSDAVKTVMSISKEKKDASPTKRGTTTKGRVKTSQPDLTDNENGVSAVAECARLSLSCLRMLRTDAMVDGGLPNLQLEQGACVLAGRLLALGLNDAAYKELRGLKRRIQSYLEELPSGRKRTGRKDAEDGEETAKERMSDLLSFSDIANARSIHGLLVSFQSNALRLIAAEKRPATVQKLVPSLQLTDESSPANVIMASIDSGALTKDKAAVQLQLLSSTVLSLSASGASTGKERLRPSIVLSLQLLALEIRCMSWKLSGHACEDNKEMWDPLARYIGAFAQATKSIEKAEFAVIYKNIVRLQSAFSKTQNCATRSTDNLSVARIATILGQLAQDAGCFDEALQLFTESLNPLSSSQCLGMATVRCKIAALHFQAFKSSVKLPGDVSDAVSQATAALSISLKGSSHDLDELLVQAAKLKKLAMGWFGDLISKGQGSQCENVVFPRICEFLSSFVRFLRRYIGRRPENDELNDREIFQKRIDAAQNIVLAAVDSTIAIGKLSVMSQRPAWEETVSTLLDCQRLLATIEPFDEVDVATADSIDQALVKLSNLFWSRYLKEKEAGKNARELLPLLKQSAYLLSGCSPSQRATGFAPLKYERLAHTYIEGNMVSEAEVAFRQSITDHIAAGALDKIASSTDGCFPHQMNQDPKRSGFTLGRVLSAYLKVKLRNKRSAVNEIFDDETLPSVQRGHVLEWQLGILTEIHGTSNNDNVFRSVFAEVATRLFKVYPAEQHPVRRLRVLLSGLRFALEQPGFLDSSLLQRFADEGRKGLDDDDYQDDDDIKSLAVYLKNSVRLTLGLQQGSLGPEELELIVSTWTSILRFCHDLKSLVACVGNVEYFLLQMKAVVDYTEIHGLWKFQLSTLELVLRVTELHGAGTFSEAIIVLSRLVLQYCRMGFCIKAHSLLSRADGYIANHEVSCLARLSYELARVGFLLETGDNQKAATVLSTARMIYEKHQATEDLDACSVLTKISWERLVADAAFMSSRLSFAQGSIKDALYFAKLSVRLNCRIWAKVEKLAQKKQEKAVVGDSSELEIVVEGMAKLEVSQTSSTYSQGAPFWPHIGSHHSSLLHLANLSAHHGLFQDAIYYGEQALKINKSLNANVRLIASQAHLGSHWILGGHISEGQQLLASAKALSDKLGSSIELVSLRLSLAALHRVEGDYRNEYRTLREAEKLLGGLFESQADSADIPDLEEKMDKLRVRPKSRSTRQPATTATRRTRSATTSARSTPKPPQSVEATNASNTLLQMKSEILLQQAASLRAQREFEAASTLLSDARKFAVTRNSRISVHLGESEHLLADAIRNFANHAVYCVLPESTISLPSLEPKAASESSSKSATRKTRAPTRGTRTKAQAATEDFSVMLSKAGDCLNGIFDTATQLGSTLDSHSASRLMSRISMLSHVTASPNHILWPHSPANMNEVGRIGAFARERAAIRIDKRLADYCDPLLWPRSELESEGVSPDFTKEYVDILPDNWNVLSLSLSADRAEFVVSRLHRGCSPFLLRLPLRRGNSEDEEEQFTFEDGRDEMKELIRLANESAHAAKLQVDRQMKKEWWKNREALDRRMENLLQNIENVWFGGFRGIFSPIPLCEKSLARFASAFENILENHLPSRRKGSRAQGPKLTLHPNVLELFVGVKGLDDQEDPEDTLMDLLYFVVDILQFQGERNAYDEVDFDMMVVETLDAVRAYHEAAKDQATQRPNNTVLVLDKSLHLFPWESLPCLQGLPVCRVPSLECLRDRVLHLRSGKQSALSIDRRNGTYILNPTGDLKTTQETFEKDLSSLKGWTGMVNRQPTEDEFKDSLQSKSLFLYFGHGSGAQYIRGRTVKRLDRCAVAFLMGCSSGTLTEAGEYEPYGTPMNYLQAGSPALVATLWDVTDKDIDRFAKATFEHWGLIGNGHRGNEGIGEAGVALDAAVSQSRGACVLKYLNGAAPVVYGVPGVFLH
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MSAKWMLTLTSLCEQSGVGVATLSNSMLLYMLTYKASPSYGDYRRLMFSYTIVEMVYSFLSFTSGMKAHSTDTSFVVFNFYHGYVSRSIAPLFLIDFCGIYFTLILILVLHFIYRYFVVCDAGKLENFKGWYLMLWVVGSTISGFSMAYLKYWTFPEREHLTNELREDFLQYFALTMEEIVYNGPNYYVCKKFNDCKKPRADWITMFILCGGLIFSVSTMCFCGYSCCKKLGEHKNRLSSRTANLQKQLMAALIIQSVIPIIFMYIPVFLLFMTPMFRVGFGPYDNIAMATLAIYPPVDQFIIIYVIEDFRTAVKDLFKCGKMQESAPSN
The following text describes a protein:
Function:
Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Nucleus, nucleolus. Nucleus.
Sequence:
MEFWGVAVTPKNATKVTPEEDSLVHISQASLDCTVKSGESVVLSVTVGGAKLVIGTLSQDKFPQISFDLVFDKEFELSHSGTKANVHFIGYKSPNIEQDDFTSSDDEDVPEAVPAPAPTAVTANGNAGAAVVKADTKPKAKPAEVKPAEEKPESDEEDESDDEDESEEDDDSEKGMDVDEDDSDDDEEEDSEDEEEEETPKKPEPINKKRPNESVSKTPVSGKKAKPAAAPASTPQKTEEKKKGGHTATPHPAKKGGKSPVNANQSPKSGGQSSGGNNNKKPFNSGKQFGGSNNKGSNKGKGKGRA
The following text describes a protein:
Function:
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MGWFWSETPKDLEKPMGHPKGDISQCPIDHSKFSKQFEKKKVEAETSSAPTKCPVDHSQRSSWFSWAKPSGPDANNNKLNPLNMMPDLSSQRAPGQSVDLPLERTMSTIPKGKESSAGVWEYPSPQQMYNAMLRKGGGEIPEDAVESMVDVHNFLNEGAWVEICDWEKKYTERTDVEPRLMKFQGRPNDMSPRAQMIQALGKVFPATFGSAAPFDRHDWTVLRAVVPAATEKDTVWQEVRYVIDYYSGDDEGESGDTPTFVLDVRPALDSPGAVIDRVGKWSSETWRKAMGEPPLPKYVPSNLRDIEE
The following text describes a protein:
Function:
Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
Subcellular Localization:
Secreted.
Sequence:
MPSIQLPVLLLCLTLSGVCLNGRQFPPELSENMGRSSLDDILQRSGSHMLQSVLKKVEKKEEMNKELNMPLPQWLSKRQHPGKRYISDPEKRQHPGKRDVEEKASFGDIQKRQHLGKTEVEGYLVNYLELKKRQHPGRRSLWDQSTDISSSQLTYLNELSKRQHPGRRYLMYKHQHPSKRGWNDELDLSDQNWEKHQQFGNRDRDSDSPDYTGPCDLQQSAICNKDSLLLDLAEKFSKEGVEEKHQHPGRRSAWENETEE
The following text describes a protein:
Function:
Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.
Sequence:
MVIRVLFRPVSLIPVNNSSTPQSQGPISRRLALTALGFGVLAPNVLVACAGKVTKLAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKAVPVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDEAQGARVHWRPREYYPAGTTVDVDAKLYGLPFGDGAYGAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADLARNVTRNGIHVVTEKYSDFYMSNPAAGYSHIHERWAVRISNNGEFIHANPMSAGAQGNSNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYADGDIWDWAVDWDTWVSMSALPPPAAKPAATQIPVTAPVTPSDAPTPSGTPTTTNGPGG
The following text describes a protein:
Function:
Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAVEDDVSLIRTTTLVAPTRPTITVPHRPPAIETAAYFFGGGDGLSLSPGPLSFVSSLFVDNFPDVLTPDNQRTTSFTHLLTSPMFFPPQSSAHTGFIQPRQQSQPQPQRPDTFPHHMPPSTSVAVHGRQSLDVSQVDQRARNHYNNPGNNNNNRSYNVVNVDKPADDGYNWRKYGQKPIKGCEYPRSYYKCTHVNCPVKKKVERSSDGQITQIIYKGQHDHERPQNRRGGGGRDSTEVGGAGQMMESSDDSGYRKDHDDDDDDDEDDEDLPASKIRRIDGVSTTHRTVTEPKIIVQTKSEVDLLDDGYRWRKYGQKVVKGNPHPRSYYKCTTPNCTVRKHVERASTDAKAVITTYEGKHNHDVPAARNGTAAATAAAVGPSDHHRMRSMSGNNMQQHMSFGNNNNTGQSPVLLRLKEEKITI
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MVWDPNWLDRPVALVGLSGCGKSTLARLLARALSWPWYDTDAAIAAAAGMSVADLFQTYGEAEFRVRETAALTEALREAQVIATGGGIVLQPENRRMLREYATVIWLDAADATILTRLAADAEQRPLLHGDAAARLAELRARRTPLYAEVADVIIATDGKTPLELVQQVIAALRQGR
The following text describes a protein:
Function:
Penicillin-binding protein with an unknown catalytic activity. May have a specialized role in the morphogenesis of spore cortex, which is a modified form of peptidoglycan. Spore cortex formation is determined primarily by the mother cell.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSLAKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNMSEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLSHVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDMKLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVDPSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWKRGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGILFPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTVKKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKYLENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVKPRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGTKVKEGSKIRVYLTEEDEKEAAD
The following text describes a protein:
Function:
Required for Na(+) uptake into the cell, especially at low external Na(+) concentrations or low Na(+)/K(+) ratios. May be part of a sodium cycle that permits re-entry of sodium into the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIKLPVLLADINIQSLPTEPELILNNLAITTLVENLIILLLVATLVALVARWLKIPYVIGLVLAGLAIPRGLSVGLNPELILNFFLPILIFEAAINTDISRLRSTIKPITVLAGPGVVISAAITAVLLKIGLGLAWVTAAGVSVILTITDTVSVIAAFRSVPVPRRLATIVEGESMLNDGVAMVLLSVITTIHIQGGFSAGEGIRQIFVAFVGGGLVGLGLGYLCVGLFRQLNDDLSDILLTVSVSLGTFQIGQMLGVSSAIAVVVAGLVIGNLALKQTSASIKVTLLSFWEYAGFGVNTLIFLLVGIEVYPSILLSTIPAALIAIVAYQIGRVFSIYPLLYLLSFFDRPLPLRWQHVLIAGNVKGSLSMALALALPLTLPGRDQVVTLVFSTVMVSLIGQGLSLPWVVKKLQLSKPSPLAQKIAMLQLNLVTAKAAQGELKYLLEAGSLPKFLYEELFADYQARIANSEQELREFYNQRNLIFSEGEVEKKYIDGLYRRLYIAEKSAINDALAKGILADDISDEYLQVLNEKLLALQDD
The following text describes a protein:
Function:
Involved in plants secondary metabolism. Functions as acyltransferase to form the sinapate ester sinapoylcholine also known as sinapine. Able to convert in vitro benzoylglucose into benzoylcholine.
Subcellular Localization:
Secreted.
Sequence:
MRNLSFIVLFLLTLFFIHHLVDASLLVKSLPGFEGPLPFELETGYVSIGESGDVELFYYFVKSERNPENDPLMIWLTGGPGCSSICGLLFANGPLAFKGDEYNGTVPPLELTSFSWTKVANILYLEAPAGSGYSYAKTRRAFESSDTKQMHQIDQFLRSWFVKHPEFISNPFYVGGDSYSGKIVPGAVQQISLGNEKGLTPLINIQGYVLGNPVTDKNIETNYRVPFAHGMGLISDELFESLERSCGGKFFNVDPSNARCSNNLQAYDHCMSEIYSEHILLRNCKVDYVLADTPNIRTDRRRVMKEFSVNDSSSLPPPSCFTYRYFLSAFWANDENVRRALGVKKEVGKWNRCNSQNIPYTFEIFNAVPYHVNNSLKGFRSLIYSGDHDSMVPFSSTQAWIRALNYSIVDDWRPWMMSSNQVAGYTRTYANKMTFATIKGGGHTAEYTPDQCSLMFRRWIDGEPL
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors (such as IF-2, EF-Tu, EF-G and RF3).
Sequence:
MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQLREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKNHEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQKEEQGA
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MIAEKPSWLRHEGMQIFSIDVQPSGLRFATGGGDHKVRIWNMKSLGADMESLDTSERLLATLRDHFGSVNCVRWAKHGRFVASGSDDQAILIHERKPGSGTTEFGSGEPPDIENWKVVMTLRGHSADVVDLNWSPDDSSLASGSLDNTIHIWNMTNGICTAVLRGHSSLVKGVAWDPIGSFIASQSDDKTVIIWRTSDWSLAHRTDGHWSKSLGSTFFRRLGWSPCGHFITTTHGFKKPRHSAPVLERGEWSATFDFLGHNAPIIVVRFNHFLFKKNSSNTQEGKSEPVGWSNGGSKTGPKEPQPYNIIAIGSQDRTITVWTTASPRPLFVAKHFFTQSVVDLSWSPDGYSLFACSLDGSVGAFHFEAKELGQSLNDAELDELKRSRYGDVSGRKINLAESPAQLLLEAASTKQTSAKKAVSNVQQKKTTAKACVSAGNTTKNSKPQVKDVKKIGGPVGNEPNMVTTTGLISGPVKQKEYRRPDGRKRIIPEVVGGPVQPESISSAAQQFDFPIVSSEHIKSSDKAISTNDDIRASTLGGSHVRHSDLKERSGVTARVTISDGLIIEKVSDTSGDGGINVQQMGNSMTSNSLAACSSTLSIRVFDKKGGVGTSPVLLEARPREHTVNDIAGLANTSMMKETEIVCTRGDQTLWSDRISGKVTVLAGNVNFWAVGCEDGCLQIYTKCGRRAMPTMMMGSSATFVDCDECWSLMLVTRKGSLYLWDLLNRTCLLQDSLTSLVASSPNPSTKNEGTIKVISAKLSKSGSPLVVLATRHAFLFDMNVKCWLRVADDSFPASNLSSSWSLGSIQSGELAALQVDLRKYLARKPGWTRMTDDGVQTRAHLEAQLASSLALGSANEYRQCLLSYVRFLAREADESRLREVCEGFLGPPTGMAEEPSSDSNNLAWDPFVLGMRKHKLLREDILPSMASNRKVQRLLNEFMDLLSEFEIVDPNQDQMALVLPKSSSPATKLIENSSVAIDKEDGAQAKTLD
The following text describes a protein:
Function:
Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for E.coli to utilize dodecanoate or oleate as the sole carbon and energy source for growth.
Sequence:
MMILSILATVVLLGALFYHRVSLFISSLILLAWTAALGVAGLWSAWVLVPLAIILVPFNFAPMRKSMISAPVFRGFRKVMPPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPRLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLEFSAYAQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKDHYLPRLARGQEIPCFALTSPEAGSDAGAIPDTGIVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEKLLGGAEDLGITCALIPTTTPGVEIGRRHFPLNVPFQNGPTRGKDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIRRQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGQSNFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMEAAKNNDVNAFDKLLFKHIGHVGSNKVRSFWLGLTRGLTSSTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISARLGDILSQLYLASAVLKRYDDEGRNEADLPLVHWGVQDALYQAEQAMDDLLQNFPNRVVAGLLNVVIFPTGRHYLAPSDKLDHKVAKILQVPNATRSRIGRGQYLTPSEHNPVGLLEEALVDVIAADPIHQRICKELGKNLPFTRLDELAHNALVKGLIDKDEAAILVKAEESRLRSINVDDFDPEELATKPVKLPEKVRKVEAA
The following text describes a protein:
Function:
Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.
Subcellular Localization:
Secreted.
Sequence:
MKVLISSLLLLLPLMLMSVVSSSSHTGVARGQRDQRQASGRWLREGGQECECQDWFLRAPRRTLMAAPRLTKPCPCDHFKGRMKKTRHQRHHRKSNKPSRACQQFLTRCLLESFALPL