The following text describes a protein:
Function:
Involved in the synthesis of chondramides. Activates R-beta-tyrosine and probably phenylalanine.
Miscellaneous:
MISCELLANEOUS: Chondramides are secondary metabolites with antifungal and cytotoxic activity. They are non-ribosomally produced depsipeptides consisting of a polyketide chain and 3 amino acids (alanine, N-methyltryptophan and beta-tyrosine or alpha-methoxy-beta-tyrosine).
Domain:
Two module-bearing peptide synthase. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, condensation and epimerization (Probable).
Sequence:
MLREGQGTVAHAPPRPLPHADVLPVSQAQRRLWFLCQLDGASVAYNMPFVTALDGHLDARALQRALDEIIRRHESLRTTFRLQAEGPVQVIHPPAPLDLPLHDLRSLDEPARAAEIQRRIDRAAHQPFDIERGPLLRAQLLRQSETRHVLCLVIHHIVADGWSIGVFVREFEALYGAFSASRPSPLTEPPLQYADFSRWQEERFPPSAVERHLTYWKQKLSDVQPLQLPADHPRPAVESFRGDHTIFRLDRGLTRGLHELAQCEGVTLFITLLSAFNVLLGRYSGQDDLAIASGTANRKHAELEGLIGFFVNTVVIRTDLSGNPTFRTVLSRVLASVMEATEHEDLPFERVVEELKPERTASHNPLAQVALTLQSFASNRLTLPGLTTSPCDFRFRTSKLDLMLLVTEVDGELEVVVEYNTDLFEDATIARMSAHLRTVMAAMVADPGARIGDISLLTTEERHRLLVDWNDTALACPEAEGVHHAFEQNAARQPDAIAVVFDGDPISRITYGALNERANQLAHHLIQQGVGPDVVVGIHVERSITMIVALLAVLKAGGAYLPLDPTYPQQRLAFILADAGAQVILTQEKWFDDLPPHTARVLDLDAIAPQLDANATSNPPLRATADHLAYIIYTSGSTGNPKGVLIPRRDTWSVARALAETYALTPESRVLQFASLNFDGSVVEITMTLFSGAALHVAPQEKLLPGAPLNAFLQRHAITHVQLAPSLLARLPPEGLEHVRTIMVAGEASSVGTVRGWLPGRRILNGYGPTETTVGAAMIAFTEADDAYLAKLDALPIGRPFYNKRVYLLDARLQPVPVGVPGEIYVASPGLARGYINRPAATAEKFLPNPFSETPGERIYRTGDLARYLPDGNLVFLGRVDNQVKLRGLRIELEEIESALKSHPHVGDAAVIVHEAPADQATSERDGKRLVAYVVPRRGWEPEGAQSDHIASWQTLHEQLLDESQAPEDWSFNITGWKSSYTGEALPAAEMRLWVESTVERILAHGPKDVLEIGTGTGLLLARIAPRVRAYLATDFSLEAIRYLETCKARAPELSNVTLLQRMADDFTGFSAGQFDTIVLNSVVQYFPTLDYLSAVIEGALRVLKPGGTLFLGDIRNLALLDAFHASVQTAKASGTLSRDELRYRVQQGVMNENELVIDPRFFTALSRKFPQITHVEVTPKRGLHRNELTLFRYDVALQVGGTPKGAPTITWFDWREEGLTSDSLPPWLSDTLATSPDAGVGLRRVPNARLQPDLAILSWLATRAEASLDAWRARQHDVPEGCAPEALWALETTWPGRVHLSWAAGHPDGSFDLVVTPPQAERRAPWSPAVDLTDEQLSAYVNHPLQAKVVRETLGQELRRYLQDKLPAYMVPTVLIPLPALPLTSNGKLDRRALPAPDIERRSRASTYVAPRNAREETLVAIWSKVLGVDPIGVEDNFFELGGDSILSIQIVGQAKQAGFSLTSRQMFEHQTIAALAEVASASKSIQAEQGLVEGSIPLTPIQRWFFETHQETPDHFNQAILLKVSADVSASRLEQAFHHLFTHHDALRMRFSRTADGFEQVNLGPIEGVTVDVIDLAHLPAAEQTRALTEAATSLQQRLSITSGPLSRIALIHLGAEQPARLLWILHHLVVDGVSWRILLDDLVTVLRQLEAGQPARFPPKTTSFKEWSERLHATAQQEQANTASSRAERDAWRSVPVPALPLDHPQGTNRKASAAQVQVALSVADTHALLHDAPRAYGTQVNDLLLTALALAFNAWTGDATLALDLEGHGREEDLVGADLSRTVGWFTTMHPVALRLPGRELSLALRAVKEQLRAQPGRGIAYGLFRYASGEGSLASWPAPQVNFNYLGQLDAMTDTAPLLGFAPEEIGPSDGPTGDRTHLFQVNGMVKDGSLQFTWTYSRELHRPETVQKLAHDFAETARRLTQHCLAHESHPTPGDFPAVTLSQNQLDVVLDALGADRDNVAAIYPLTSLQEGLLFHSLSAVPAPVPALADEDDEEDDELDEEFDAEVDEEDEDEEEEEDDDGENVYVTQLVFRIQGPLDAEKFRTAWQETVQRHPLLRSRFVWEGCERPLQVVLRSADLRWEEDELEEDSWSSPLRVHARREQQAGMLLDEAPLFRLNLLRAEDTEHHLIWTSHHILLDGWSGPLILKDVFASYDAQLLGESRTAADPPPYEAYVAWLKRQDGTASERFWRENLRGFSAPTPLVVDNEEPTGKQKHLHHRCKLSAETSQALKALAESFRVTLSTVYQAAWALLLHRYSGMSDVLFGVTVSGREADVPGIEEMVGLFIRTVPLRLHVDESQTLGAWLKEVQARQIEQREHQYVSLVDIQRWSDVPGGTQLFDSMFVFENYPLDSALLEQSGLRLTVSTMASPTHYPLVIAVVPGRTVETLFDHDTSRLSKHTVERLAAHWVELLTGMARRPDARIHTLPHLTSAEREKLLVTWNARPYVDEQRKYRGEEEPFGEELAAESTFLDLFQHHVAQTPDALALVGPSLQSTDERPVSRTYRALSARVHLLARHLRGLGVGPEVTVGVCLDRSIELVIGMLAIFEAGGVYLPLDPSQPLERLAYLVSDARPEVVLTQQRWNDRLPEQATRRVALDTAWAEIEAQPEVSHQHRTAGDNLAYVLYTSGSTGTPKGVQVTVDNLSRLTPALITAFDVTPRSRVLQYSSLSFDGSISEVAMALGAGAALHLAPAHELVPGPPLQKLLATRAITHVTLLPAALRWLSPRGLPALDVLIVTGEACPASLVRTWASGRRFVNAYGPTEITVAATAMECPVTMFQETEQPPPIGCPLQSTEIYILDAHLRPVPVGVPGDLYIGGAKLTRGYIHRPALTAERYIPHPFSDRPGARLYVTGDIARYQLDGTIDFLGRRDNQVKVRGYRIELGEVEAALNDHPGVREAVVVAQKDGAGDNRLVAYWAAKSTPPTTTEALRDALSKRLAAYMIPSVFVRMDALPLNATGKIDRQGLPPVDDTMLDREQFVAPRTATEETLTAIWSSTLGVARVGIRDDFFKLGGHSLLALNITTQIQKRFGHVITVDSIFRAPTIAVLARVIDEALAPTGARRALSLVVPLRERGTKVPLFFAAGMGMHAHYLRPLAEHLGEDQPFYALQSPAQGGEITDMATLVDTLIGAIQQIQPSGPYHLGGHSAGARIAFAVALELQRRGAEVPLVSIVDMRPPGRGATSDESAEWTQIGGLIGYVTMIKQAIGEGVLFVTPEELRKLDEAAAWQRTLDAFIAARWMPKDADVEQLQHLCAMNQNVVRVVRDHVPTDTHQGKLLVFSAAFAMRNGRQVSTEGWQAFCANPVTTHEVPGDHMTMLREPDVRGLAIKLRREIDELALERTDEAPGLPTPPEFPVVWEHPEDARMLWVHDVTHCREQMTPLDFCLRQQAMVEGSNLANLAYGVPFTGEIRLINTYVYQKIIPTTASPTELAAAMKRAEASVAALLPDLGRWWTETLLPEIEAHLEALDPENNYDFVHRHTLVEALAEAHRRTARLWEIHFRLLQPVMLAISRFVDLCKDLSTDDDPIDPYALLVGFPNKTTEGNRALWSLSRLALETPEVASILTSNEASRVSWKLRSTRGGRAFVAQLDAYLATYGQRNDSTYLDAPTWEEDPTPVIRNLQAYMTQPERDLDAELNALSEQRTQRLDALRARLRHYPRAVVDEFEQALTAAQTATVLSEDHNYWIDYKITHRLRHLCLYLGEQLKDWELLGDCEEIFYLSMDDVSRAAVETKRGGPFSANQRFYHLACARKDEAKRFHGVQPPRFLGTPSPLPALHDALSLASARFTGVAPSPSNDEKEIVGLSGAKGKARGKARVARNLADVPTLEPGEILVAMAMLPAWTPLFATVAAIVTDSGGMLSHAAVVAREYGIPAVVGTQVGTQRIRDGQLVEVDGERGVVTLL