lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing.
Miscellaneous:
MISCELLANEOUS: Plants silencing VIR exhibit pleiotropic phenotypes, including aberrant root cap formation, gravity response and lateral root development, and defective development of cotyledons.
Subcellular Localization:
Nucleus speckle. Nucleus, nucleoplasm.
Sequence:
MVRSEPCVLFAQTFVHPQLDEYVDEVIFAEPVIITACEFLEQNASSSSQAVSLVGATSPPSFALEVFVRCEGESKFKRLCNPFLYTPSAPYPLEVEAVVTNHLVVRGSYRSLSLIVYGNIVKDLGQYNIILEGRSVTDIVSSTEGNLEDLPLVLHSVNRTIEECLSSLDIVSLPLAAVDLPVEVKRLLQLLLKIFDKLATNDVVNKFVDTVVSGVSSYVTDNVDFFLKNKNCSAVTSSLDSGLFHDIVDRVKEDILDLNEIQESDVALGLFSFLESETYLATSQQLVVMLSPYIQFERDSLCTVLPKLSKGKATLLGLSLAFLLCSGREGCLQFVNSGGMDQLVYLFGHDGQNSTTITLLLLGVVEQATRHSVGCEGFLGWWPREDGSIPSGKSEGYCLLLKLLMQKPCHEIASLAIYILRRLRIYEVISRYEFAVLSALEGLSNSHGAATHNLNMLSDAKSQLQKLQNLMKSLGSVEDPSPSAYAERSLVSDHSEGWLSYKATSKLTSSWTCPFYSSGIDSHILALLKERGFLPLSAALLSMPELHSKVGDIMDVFTDIAMFIGNIILSFMFSRTGLSFLLHHPELTATIIQSLKGSVDLNKEECVPLHYASILISKGFTCSLLEIGINLEMHLRVVSAVDRLLKSIQQTEEFLWILWELRDVSRSDCGREALLTLGVFPEALAVLIEALHSAKDMEPAVENSGISPLNLAICHSAAEIFEVIVSDSTASCLHAWIEHAPVLHKALHTLSPGGSNRKDAPSRLLKWIDAGVVYHKHGVGGLLRYAAVLASGGDAQLSSSSILALDLTPAENGAGESTNVSEMNVLDNLGKVIFEKSFEGVNLSDSSISQLTTALRILALISDNSTVAAALYDEGAVTVVYAILVNCSFMFERSSNIYDYLVDDDHGCSSISDFLSERNREQSLVDLLIPSLVLLISVLQRLQGTKEQYRNTKLMKALLRLHREVSPKLAACAADLSSHYPDSALGFGAVCHLIVSALVCWPVYGWIPGLFHTLLSGVQTSSVPALGPKETCSFLCILSDILPEEGVWFWKSGMPLLSGLRKLAVGTLMGPQKEKQINWYLEPGPLEKLINHLTPNLDKIAKIIQHHAVSALVVIQDMLRVFIVRIACQRVEHASILLRPIFSSIRDGILDQSSTRDTEAYMVYRYLNFLASLLEHPHAKGLLLEEGIVQLLVEVLERCYDATYPSENRVLEYGIVSASSVIQWCIPAFRSISLLCDSQVPLLCFQKKELLASLSAKDCALIFPFVLKFCQVLPVGNELLSCLGAFKDLSSCGEGQDGLVSLLFHLFSGTEESVSERWCDTNSLSLDQLDMKKNPPFLSCWIKLLNSINSKDGLSSLAMKAVNVLSVGSIRLCLDGKSLDSKKVAALKSLFGLPSEFSGTDTFREENIGLIEQMVTLLSSMTSGSDSSATAEMKPYLHEASQSLLSLLKDGNIDDIISCKGVFVSPGNLDMDDLVSRNIEDDLYQRGLEDKFWWECPETLPERLPQSSLPAKRKLPTLESSSRRAKGENSSVDIPTQNSIQRGMGSVSLPPAPTRRDAFRQRKPNTSRPPSMHVDDYVARERSVDTAGNSNAITISRAGSSSGRPPSIHVDEFMARQRERGQNPSTIVVGEAVVQVKNPTPARDTEKVAGKPKQFKADPDDDLQGIDIVFDGEECEGPDDKLPFLQPDENLMQPAPVMVEQNSPHSIVEETESDANGSSQFSHMGTPVASNVDENAQSEFSSRISVSRPEMSLIREPSISSDRKFVEQADEAKKMAPLKSAGISESGFIPAYHMPGSSGQNSIDPRVGPQGFYSKSGQQHTGHIHGGFSGRGVYEQKVMPNQPPLPLVPPPSVSPVIPHSSDSLSNQSSPFISHGTQSSGGPTRLMPPLPSAIPQYSSNPYASLPPRTSTVQSFGYNHAGVGTTEQQQSGPTIDHQSGNLSVTGMTSYPPPNLMPSHNFSRPSSLPVPFYGNPSHQGGDKPQTMLLVPSIPQSLNTQSIPQLPSMQLSQLQRPMQPPQHVRPPIQISQPSEQGVSMQNPFQIPMHQMQLMQQTQVQPYYHPPQQQEISQVQQQQQHHAVQGQQGAGTSQQQESGMSLHDYFKSPEAIQALLSDRDKLCQLLEQHPKLMQMLQEKLGQL
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGVKMVKQPLVMSIYYCLPLFHLWSAAATRIVYSVTEELSLGTTVGNLAKDLHLNVQELEDRGFQISGAYKEYFEVDLKTGALLVKGRIDREELCSRKVKCSLEVEAIVNSPLNLYRFEIKILDVNDNAPFFRIPGIALNVSESAVPGEKFALPKAFDADVGAFSVKGYKLSANEYFSMDAQNNGDPTESAEMELRKALDREKQAVIKLTLTATDGGKPPKSGTLLITVNVQDVNDNIPVFDKALYKATVLENAAPGTSVISVHARDLDEGPNGEIQYSFINQDNDNTVDKFSINVLTGEISVNGELDHEKNNAVEIRVQAKDSGVSPRTSHCKVLIEIKDVNDNPPEISVTSVVNTMKEDAPPDTMVGLITVKDYDAEENGDVDVNILDSVTFKIKNTYKNHYSLLVNGPLDREVASEYKIRITAADKGQPPLSTTAIVTVHVSDVNDNAPRFKEPEINIFVKENGPTGDVIFTLTADDPDIGENAKVKFLANDQKDKLLSSVITVNSDTGDIVALQSFDYEKLKTFQFKVQATDSGVPPLSSNVTVNVFVLDENDNSPSILAPYSEHSSVNSENIPYSAEAGYFVAKIRAVDADSGYNALLSYHLSEPKGNNLFRIGTSSGEIRTKRRMSDNDLKSHPLLVLVSDNGEPSLSATVSIEVVVLESTADMQTPFRHVPLKEDSFSDLNLYLLIAIVSVSVIFLLSLISLMAVRCHRTDGRFSRYSAPMITTHPDGSWSYSKATQQYDVCFSSDTLKSDVVVFPTPFPPVDAELISINGADTFTRTQTLPNSEKLEGNKERYRGKDADQKCKRFQKTCLLKQAKKKKKEVSKPNESRQCEIKCSNLGKAFQRKSVKT
The following text describes a protein:
Function:
Involved in pre-rRNA processing and ribosome assembly.
Miscellaneous:
MISCELLANEOUS: Disruption of NUCL1 induces NUCL2 expression.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKSSKKSVTEVETPASMTKPLKKGKRDAEEDLDMQVTKKQKKELIDVVQKEKAEKTVPKKVESSSSDASDSDEEEKTKETPSKLKDESSSEEEDDSSSDEEIAPAKKRPEPIKKAKVESSSSDDDSTSDEETAPVKKQPAVLEKAKVESSSSDDDSSSDEETVPVKKQPAVLEKAKIESSSSDDDSSSDEETVPMKKQTAVLEKAKAESSSSDDGSSSDEEPTPAKKEPIVVKKDSSDESSSDEETPVVKKKPTTVVKDAKAESSSSEEESSSDDEPTPAKKPTVVKNAKPAAKDSSSSEEDSDEEESDDEKPPTKKAKVSSKTSKQESSSDESSDESDKEESKDEKVTPKKKDSDVEMVDAEQKSNAKQPKTPTNQTQGGSKTLFAGNLSYQIARSDIENFFKEAGEVVDVRLSSFDDGSFKGYGHIEFASPEEAQKALEMNGKLLLGRDVRLDLANERGTPRNSNPGRKGEGSQSRTIYVRGFSSSLGEDEIKKELRSHFSKCGEVTRVHVPTDRETGASRGFAYIDLTSGFDEALQLSGSEIGGGNIHVEESRPRDSDEGRSSNRAPARGAPRGRHSDRAPRGGRFSDRAPRGRHSDRGAPRGRFSTRGRGPSKPSVMESSKGTKTVFNDEE
The following text describes a protein:
Function:
Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.
Subcellular Localization:
Nucleus.
Sequence:
MTAFVDAECSQLMDSLTAFSLPRTSAKDYADFKSRIETFFDDYGTLSRWPCKPPELSPPQCARFGWTCANESMLVCAACKEYLDCEVSSSLGRKLHKECLSRLVSLLEGAHKPCCPWKTAPCPKSYTVMQPVLRKDALSQLRERLETLGPILSTLPVLNTDKIFSLLSPEDIQRIGKLVDKDRGTETQRADLLLAITGWQAGAGSGKMKLVTCEYCSRKVATFFYKSAPISESRDEVTTSQDKGACSPGHGTKRKREEDELDPVHEHRPWCIWVLNDDAGKPGWLVFSECLLRNVDSSHDDSRLSTSSADAFKHDVEKIISSWREVVKHPTVQKTTTS
The following text describes a protein:
Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRGQKSKLRAREKRHQARCENQDLGATQATVAEGESPSPAYLLFGDRPQNLPAAETPSIPEALQGAPSTTNAIAPVSCSSNEGASSQDEKSLGSSREAEGWKEDPLNKKVVSLVHFLLQKYETKEPITKGDMIKFVIRKDKCHFNEILKRASEHMELALGVDLKEVDPIRHYYAFFSKLDLTYDETTSDEEKIPKTGLLMIALGVIFLNGNRAPEEAVWEIMNMMGVYADRKHFLYGDPRKVMTKDLVQLKYLEYQQVPNSDPPRYEFLWGPRAHAETSKMKVLEFVAKIHDTVPSAFPSCYEEALRDEEQRTQARAAARAHTAAMANARSRTTSSSFSHAK
The following text describes a protein:
Function:
Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormancy response. Regulates an approximately 48-member regulon. When phosphorylated binds and activates the promoter of DevR regulon genes in response to hypoxia. The presence of target DNA increases stability of phospho-DevR in vitro. Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters. Accepts a phosphate group from DevS (DosS) and from DosT. Does not regulate transcription of dosT.
Miscellaneous:
MISCELLANEOUS: The dev nomenclature derives from the increased expression (differentially expressed in virulent strain, dev) of these genes in virulent H37Rv versus avirulent H37Ra. The dos nomenclature derives from experiments in M.bovis showing the same genes are essential for dormancy survival (dos).
Subcellular Localization:
Cytoplasm; Host cytoplasmic vesicle, host phagosome. Note=(Microbial infection) In human monocytes after in vitro infection.
Sequence:
MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
The following text describes a protein:
Function:
Catalyzes the decarboxylation of tryptophan to tryptamine. Tryptamine is a neurotransmitter that induces the release of serotonin, which is suggested to modulate gastrointestinal motility. Therefore, the tryptophan decarboxylase from the gut bacteria Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9) may influence host brain and behavior. Has weak activity with tyrosine and phenylalanine.
Subcellular Localization:
Cytoplasm. Note=In vitro, tryptamine is excreted into the extracellular fluid, suggesting that the bacterium has the potential to excrete tryptamine in the host gut lumen.
Sequence:
MSQVIKKKRNTFMIGTEYILNSTQLEEAIKSFVHDFCAEKHEIHDQPVVVEAKEHQEDKIKQIKIPEKGRPVNEVVSEMMNEVYRYRGDANHPRFFSFVPGPASSVSWLGDIMTSAYNIHAGGSKLAPMVNCIEQEVLKWLAKQVGFTENPGGVFVSGGSMANITALTAARDNKLTDINLHLGTAYISDQTHSSVAKGLRIIGITDSRIRRIPTNSHFQMDTTKLEEAIETDKKSGYIPFVVIGTAGTTNTGSIDPLTEISALCKKHDMWFHIDGAYGASVLLSPKYKSLLTGTGLADSISWDAHKWLFQTYGCAMVLVKDIRNLFHSFHVNPEYLKDLENDIDNVNTWDIGMELTRPARGLKLWLTLQVLGSDLIGSAIEHGFQLAVWAEEALNPKKDWEIVSPAQMAMINFRYAPKDLTKEEQDILNEKISHRILESGYAAIFTTVLNGKTVLRICAIHPEATQEDMQHTIDLLDQYGREIYTEMKKA
The following text describes a protein:
Function:
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
Subcellular Localization:
Nucleus.
Sequence:
MLLDDLSDSEFDALPKNKAPALLDDSDLDDLDDLDDFDFSTVVKEPAKPVTKEQTAVHKPSTAQQQPTPARQQPLGQQPPRQQPSGPQRTQLPRYNADPAESTNTPDIDLNLTYPRPMDTACHHETTGLTGSFLYPSNLPFRTYQHTIIQSCLIENTLCSLPTGLGKTFIASVVMLNFYRWFKDAKIIFMAPTKPLVSQQIDACLRITGIPRHDCSVLMGGVKQADRAHEWANKRVFFATPQVVELDLDGEILDPKTVSLLVVDEAHHTSGKYSYGIVVKKLLDAHQSFRVLGLTATPASKVEGVQSVVQHLLISHLEVKGEQDPDVQQYMHNREEVKINVDLGSDINELLALTGQVLKPTLSMMASKGVLHNTDIAKISLFGVKKEIERYMFRTKYLGPAAQYKYRGIGAVVASIAHATQLLQHQGITQFYDTLKRRHDEEMARKQPTKSYEQVGDIGSILDATKTIMKKEGYLAHPKLNYLGSELNEFFSKAPEGANTGTCIIFARFRSTVNVIMEYLTKFPQVKPHEFIGQAPSREEGGGRGMTQKKQQEVISKFRKGVYNTLVATSIAEEGLDIGQVDLIICYDSNASPITSLQRMGRTGRSRDGRVVLLMTDKEMENNIKSRDNYSYIQRLMEKGSRVKLYPPNRVIPGAATDPPPPHFMKQVILPGENQEILDKTDKDHLELADVVAKGDKELRLRKDKNGHFIVPQKRKKKVLKMPENATLGFMTAKEMAMRSSQSSNGQSSQDIPNSPTPPTKRTKVDVDELEADLDEALGNRSHDSLAEDIEEELEQEEVPQHLHDLVELDDEREQDMSLEEFIGDDDFDKELEDVLNSSKSGGGQSISEGTQGTTNEVQTTTGSVQTQAVPVEQRQSQPSSGIPLAPVKMTPAPQLAESIDSSSFDDEFFDRLDEALAKPGDK
The following text describes a protein:
Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7.
Domain:
Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
Sequence:
MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
The following text describes a protein:
Function:
Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction. Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l(2)gl, and for the barrier function of the midgut epithelium. Required for maintaining the three-layered structure of the proventriculus.
Subcellular Localization:
Cell junction, septate junction. Apicolateral cell membrane; Single-pass type I membrane protein. Note=Colocalizes with Ssk, cora, dlg1, l(2)gl and Fas3 at the apicolateral region of epithelial cells in the midgut. Also localizes to the apicolateral region of epithelial cells in the outer epithelial layer of the proventriculus and Malpighian tubules.
Sequence:
MRFKLFVVCALACGFMAFVLANENISTEEFEDQIINAVPEPVKVTKPKAQAEFVEVPKATPAPKKAEADNPKTKPLALQKPTLIPVVHVSSRGTDDILTVAGLKPEKMFGALIMPNDYLGELYDVDNSGYNWDPNNNVAPPTTYSTAAGGYTITAARLAELRSNFMYWYFDKDMYGGRGDYQFDIHASMTQLHKNLNFQLPFYGFRFNYTRLSLNGYLEFSDPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCRVGRIYPSDIDQRTPGVYFRVERDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIATWKNVSFAGGIDNSLYTTNTFQMVLATDEVYTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAYEYNPYSQNMVIRDLANRGWANGFPGRHIFRVDEQILIGSCNKDIDAALLPLTFAPESGNMLGGQVVNITGPCFDPAIRVTCHFDTESVLGTYVDRNRVICVQPYLKAEGYIRFQISVGTQRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPAEIRITWNQYNLTSNANANVMISLWGYRETKIEPQLEYIDVIEASYSNSGSYVITPSNYINRNNINRDMQFGFLQINLTQPDQYSGLAISPVLWSRPIPLAWYMAPQWERQHGKRWARALCDNWIRADRFLRNFAADLPLCPCTLDQAVLDKGRFRPDRECDKDSNPSCLRHRGAIHCVVSGTPVAQGAEQQCCYDRYGFLMLTYDQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYSCCYWQEEQAVGCETYRFERRPSQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQLPVNYYGEVKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWSFNKLDDFMLPNGQVAQLNLNDLRSIHTNFGIKWMLTDREVPGVGAALFKREFGRMSGYYANATFQPNYVLDPADFLPANRSYDLERAEELCGECMQCQYDYAMTLNRDLAHFTKNYYDTIVNMQAENAVRVVSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGDQRRECLSNGLWNIPEYGYTECLREVYYTRRVAFIAIGIIFLVICPLMLCIVCGVYRYRQKQLKEDPQWQMPMLPRSRASSARNLRTLNYDDDSDTDASTLKKSRSYDKVYRTNEPLPGKPQIDFPAKKWDLDENDEDVTSSEGEKPKQLGRRSLHSASGTELDQHGSPVDGDHPDEDDDFDEADVHTGTTHPVGYHQPLSPEEADQLHRQQYSPTFSGLDSRTSGASSINYTPQAATQNRFGGVPVLPSNTQYYSRPPSSVNTVPLRTAPTPLTQDTGLPSPPLATSPTPSVQKSTEV
The following text describes a protein:
Function:
Positively regulates a late step in synaptic vesicle exocytosis.
Sequence:
MATFLAKQMISNKTSALTKSASSNNSGGGGSDNSENAMEHEEFLKQQEEERMARYVDREKKREKIRDKIRNKYNLEKRDYLSIVDLEATAPKKDSSKSNFSSRMDNYSNEGCFRRMLRCCCPCCCRR
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MSQSDVPIKKEVTVKKEDGSTPTSPSKQQEWQTIPLKSCTEEDVKDIRFHIMKFATKQDVNITKDFTRPVRLHRKDPRNMQFHLTREELDQRKREKQQMEKLKQEEKEATAKPTEESEEKEEKDKPTADAAKVAPEKPTLNKNQADMSQVAPDGGARKNRKNLFKRKTRQINLMNEEKRKLRYEEHYPWVIEDYDGKNVFVGNYEAGSTEQQHVLFVFDKDGFKMIPAEKVYRFTPRNRYATLTLEEAEAKMERNSSVPRWLMKHMEDRSISEGTPDQRFRYNSPAANGSVIANVGNGSAGRRMRTVLGGSGSGNDRDSDHDDLDYDEEFADDEEAPIMDGDEEENKLSEKKIKKEMLKAAHFDGQSEAEAEDDLDDLFETEKTRKVDKEGKKLRKVLNKREGGVYDSDEEDGLMPYISKSDLESDEESDDEVQVKKEPSSDSQTDNNTNKTSRAREVGVKSIGDGFVVIKAPPSFLGTMPPGDWNPQARKRPTPEIASPRKKIKLDETIKVKKERTLSPPPVSPTTNAATNTSSPGNGMDLNDAGPDNLLVTVKDVLDIVKDQPLTTKELLMGLKSRVSAHKDNKLRIISIVKQNLRLVDGKLVLKD
The following text describes a protein:
Function:
Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Associated with kinetochores.
Sequence:
MSDSPIELMRSTLAGFQIAPDVKTISNIQDIRAQIQSFREKELEGSQTKFKVLSRKLEISTQAMESLKQTAESSQHAEEILSREKEKFRIAKLLNITENEIMSLESQLQKMKEQLLQLEERENTSEDICQSEENANMLKLNFYHSLGFDLETAENTGNKRVIIHTENDLQTVQISNKYSPYFYSNYFWDLLDDSKDKK
The following text describes a protein:
Function:
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Subcellular Localization:
Nucleus.
Sequence:
MFVSCEKEPNIPKGYTLLLPAVSVGNVGQLAVDLIVHTLGMERIGYLHTDCLLPMVGNNPFSTSQEDASQLATGTEVYRSVEKNIVAVQQRAPLVRGKQCEFRRRLLEWAKQCGFSRVVLLTSSHAYERIDTQMTGTQLRYLLSPELQQSVGKAVGELKWTELERRRLYPGVEQRDGEEQTGVFIPGGGIARKFYQECCEAGFPLAVLLTFCAEGDNIPDAFSLANYLNQWLQLVPCKKSGGKGATPQAEWKIPSSWTLLFGSAYPPDLY
The following text describes a protein:
Function:
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity).
Sequence:
MSKEVIVESFELDHTIVKAPYVRLIGEETGPKGDIISNYDIRLVQPNEDSIPTAGLHTIEHLLAKLIRTRIDGMIDCSPFGCRTGFHMIMWGRHTSAKIAAVIKDSLKEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILEQGISDDAFERHVI
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MDAPLQMIEPVGSGLGGGGRRGGSRSGSKTSMEMTGRTPERMSNEPDDPDEDNQWLPDHDPRDERGEFASRAQFLLTVIGFTMGNGVFYQFPMAMRRYGGATFLIIYFFCMIIYGVPMLYLEMMIGQVSEGLYRKESMSQSDCARVGWAVCFLSFLRACNFSLLNAYSLEYAVEMSALFNNTCISMEQRVKNDPADEMPAREYFRHTLRGLPASFDDGKRDGNESEFKFESGRVVVCFCIVWIFACVCLLRRMRWLGKLSLFIVSGSVFLIFLFTIKCLSMERADIGLQKFFRINETAFRDPMVWTYAFRMSRLSLSLGMGGMVSMASYNRRSNDAFWLYYIYYPEVIGTFSNFHTFFSFLFYGTLVALVISTFFGLLETPISALTDQFKFCRKHRSITIIILSIIGFGVGFVQCSRVGYHIFYMFDIRVLPHFAEIMVGFQVITVACYGVANFYRDISASIGKKVNFFGYLLSPYGLLVRISQFVLSPCLMICVYVKSHKELANFVDYEKGVCKRKKALLKNSLWLCNTIGSGLFWMYPIIIVGALLALVKHRKEGKPWLQLLRPDPMHPSVRYKVPPPLGCIFGLKPIEAMPPAMGDDGSIDFPEKGIAPPKQEEAILELNYDSALVQVSISLVSNSIAAWYQRQFSVGVTRFLHIENGSINVTLHCQKNFFGRACDLHCFSDSHKICDIDGQFSCNEGWTGPDCDEKEASTTSSVSTTYLLSTTITPAHILKESNDFEFFY
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKKKESFENMLEKLETIVDSMDNGEITLEDSMKSYEEGIKLCNKLYKVLKDAEGKIKILENNKEEDFENS
The following text describes a protein:
Function:
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Bacterial flagellum basal body.
Sequence:
MGDSILSQAEIDALLNGDSDTKDEPTPGIASDSDIRPYDPNTQRRVVRERLQALEIINERFARQFRMGLFNLLRRSPDITVGAIRIQPYHEFARNLPVPTNLNLIHLKPLRGTGLVVFSPSLVFIAVDNLFGGDGRFPTKVEGREFTHTEQRVINRMLKLALEGYSDAWKAINPLEVEYVRSEMQVKFTNITTSPNDIVVNTPFHVEIGNLTGEFNICLPFSMIEPLRELLVNPPLENSRHEDQNWRDNLVRQVQHSELELVANFADIPLRLSQILKLKPGDVLPIEKPDRIIAHVDGVPVLTSQYGTVNGQYALRVEHLINPILNSLNEEQPK
The following text describes a protein:
Function:
Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle.
Sequence:
MVLEVPSITPGELHDLMRLHQDAEWPECKKMFPWAHDISFGQPPDFPHSLAIVKSQSDANNSALLRNSLEVNDIFQSWKVRTSFHREGDTCETGNDSNGFQYPNNTKELLNLLKFQIRQLELQVDDVALENAATYCHNHSILPFLKVDPRGLSLELKRYSRNKVGSNTTLKRSGQDVWGRRGLFRRFDLQCAKMIEMVDNIVIYCSRTGGSTDMQTESAPACSHEGNCPNCTTLALLLQICLMFVQKGYVGSGGSLYKTNLFICTYQNFNTDIPQTLIGTPLLDNEFFKNNTPLNLCSSPSEIVCFNNVDKNMVLCEKLELNKLTSATRLEETGLICGNTTDWHNYQIIKKNNISLTHRFEENTSIVNLKSLNYDTDNPTTSISQLYNIPNTKEVWKLIIKCTSNSQMPSLTKIRTYLDLLLDDDASKSQEHLHLTFPASGSIGLGNLNIQSVEILLNVCYLIFQVSQVQELLTFMYCEDGYTETSLLLTAYIIFHFNIPLQDALLRIHPRPFFLFPSDLQILGHLQPVLREFSPQNGSNLKLYANALKFRDKSFQLHISSELFSSIFFMKIPLESNFVNLKGPLPSRILRHLYLGSLDHAQNPALLKSLGITHIVSVGEVVSWTLNKDKIAHPVRPHRAITMTNTNEVAGNTTCNKSRNRADTVVSDKQENGSNVVISENSGFQICQIENLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNVIIQPNLFFVYELFKWWKKHYNREKDKTMDWHIICRGIAEVNMKYT
The following text describes a protein:
Function:
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
Subcellular Localization:
Chromosome. Note=Localizes to meiotic chromosomes.
Domain:
Despite a weak sequence similarity, retains most of the structural features of the ancestral archaeal Top6B subunit (AC O05207), including the transducer domain that interacts with the SPO11 subunit and the ATP-binding fold, also named GHKL fold.
Sequence:
MERTALAVCEILRYLIIHWKCEAGTAKGTLLDGQLVISIEALRSKHLPDSLHCIITIASTRSVYGGLNFKKFLQEIQPALPRLSAKLALASEEGGRSQDASGIAPCQVTFEVDENSQSLMTDCLVIKHFLRKIIIVHHKLKFSFSVAVNGTLSAETFGAENEPTLRLDNGVTLVVGFQRYVSKPKLNWSEAHCSRIHPVLGHPAPLFIPDAKADTGLLGELTLTPAAALCPSPKGFSSQLCRISSVSIFLYGPLGLPLLSSDQDQPSTAVFRDTSYFIDWKKYNLFMVPNLDLNLDTQSVLPDVNYKAESPEGNQSQNMNAQGPALLLFLFVDFQSDVPVQQAKIWGLHTLLTAHLSAILSESRSTVQQSIQSAVDQVWQLYHHDAKTQQRLQASLSVAVNSIMSVLTGSTRSSFRKTCLQALEAADTQEFGVKLHRIFYDITQHQFLKHCSCDTEQHLTPEKNISAQNTKDQHKNIAQEFPEESIGQAENKRPKRGSPNHGREESRVLGSARDRSPPKSATRDRELTEVSLTARGSQTQAAHGRAQAAEAASPAGGLEDLWLQEVSNLSEWLNPGHRS
The following text describes a protein:
Function:
Neurogenic protein essential for the development and maintenance of epithelial structure. Required in the germline for establishing the follicular epithelium and for determining the dorsal-ventral polarity. Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Brn has a role in chorion formation.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MQSKHRKLLLRCLLVLPLILLVDYCGLLTHLHELNFERHFHYPLNDDTGSGSASSGLDKFAYLRVPSFTAEVPVDQPARLTMLIKSAVGNSRRREAIRRTWGYEGRFSDVHLRRVFLLGTAEDSEKDVAWESREHGDILQAEFTDAYFNNTLKTMLGMRWASDQFNRSEFYLFVDDDYYVSAKNVLKFLGRGRQSHQPELLFAGHVFQTSPLRHKFSKWYVSLEEYPFDRWPPYVTAGAFILSQKALRQLYAASVHLPLFRFDDVYLGIVALKAGISLQHCDDFRFHRPAYKGPDSYSSVIASHEFGDPEEMTRVWNECRSANYA
The following text describes a protein:
Function:
Plays a role in regulating Notch activity.
Miscellaneous:
MISCELLANEOUS: The name 'Notchless' derives from the ability to suppress the wing notching caused by some Notch mutant alleles.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLAKKQKMQETDTEQEATPHTIQARLVSDTGEEAGPPIDLPAGITTQQLGLICNALLKNEEATPYLFFVGEDEIKKSLEDTLDLASVDTENVIDIVYQPQAVFKVRPVTRCTSSMPGHAEAVVSLNFSPDGAHLASGSGDTTVRLWDLNTETPHFTCTGHKQWVLCVSWAPDGKRLASGCKAGSIIIWDPETGQQKGRPLSGHKKHINCLAWEPYHRDPECRKLASASGDGDCRIWDVKLGQCLMNIAGHTNAVTAVRWGGAGLIYTSSKDRTVKMWRAADGILCRTFSGHAHWVNNIALSTDYVLRTGPFHPVKDRSKSHLSLSTEELQESALKRYQAVCPDEVESLVSCSDDNTLYLWRNNQNKCVERMTGHQNVVNDVKYSPDVKLIASASFDKSVRLWRASDGQYMATFRGHVQAVYTVAWSADSRLIVSGSKDSTLKVWSVQTKKLAQELPGHADEVFGVDWAPDGSRVASGGKDKVIKLWAY
The following text describes a protein:
Function:
Activates the transcription of the glnA gene.
Sequence:
MSSLLLLTNALQPSTEVLPALGLLLHNVRVAPAEGPALVDTPGADVILVDGRRDLPQIRSLCQLLRSTGLSCPLVLIVTEGGLAAVTADWGIDDVLLDTAGPAEVEARLRLATGRQQLGGDDSPMEIRNGDLSVDEATYSAKLKGRVLDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGPEHESLIGTVRNVGYRFVTPEKPEKGEKSDKSEKAERAEKAERAETPGKAAAETNEAAGARSSKV