lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.
Sequence:
MTATPGNPPTIVLVGHGMVGQRFLEALAERGLTGTHRVVVLCEEPRPAYDRVQLTSYFSGKTPEDLSMTDPAFIAEHGIELRVGDPAETIDREARRVTARSGLVVEYDVLVLATGSYPFVPPVPGKDAEGCFVYRTIEDLLAIEAYARTRATTGAVVGGGLLGLEAAGALNGLGLTSHIVEFAPRLMPVQVDEGGGAALLRTIEEMGLSVHTGVGTQEITTGEDGAVTGMKLSDGSELATDLVVFSAGVRPRDQLARDCGLAVGERGGISVDERCRTVTDERVFAIGECALAADGRVYGLVAPGYEQAETAAATIAAQEASFTGADLSTKLKLLGVDVASFGDAHGTTEDCLDVVYSDSRAGLYKKLVVGRDGTLLGGILVGDAEAYGTLRAFTGSVPPVSPESLVLPAGAGAPAQLGPAALPDDAVICSCHNVTKGTIRGAVTEHSCTTVPEVKKCTRAGTGCGSCVKVLGQLVTAELEASGVEVDKGLCGCFAQTREELYEIVGALRITSYRELLDRHGREGARGGEGCEVCKPAVGSIIASLAPSIGASGYVLEGEQAALQDTNDHFLANLQRNGSYSVVPRIPGGEIAPEKLIVIGEIARDFGLYTKITGGQRIDMFGARVEQLPLIWARLVDAGFESGHAYGKSLRTVKSCVGQTWCRYGVQDSVRMAIDLELRYRGLRSPHKLKSAVSGCARECAEAQSKDFGVIATSNGWNLYVGGNGGATPRHADLLAQDLSDAELVRLIDRFLMFYIRTADKLERTSTWLERIPGGLDHVRDVVVHDSLGICDELESLMRAHVSHYRDEWAETVNDPEKLARFVSFVNAPDVPDPVVGFVPERDQIKPDLPLLDIGRRPASADDLLEGSTRR
The following text describes a protein:
Function:
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
Sequence:
MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPLSKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHHHIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTEDGGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKGLIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQQPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK
The following text describes a protein:
Function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration after injury. Plays a role in male mating behavior by regulating spicule insertion and sperm transfer. By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, regulates avoidance behavior in response to nose touch. By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in response to fungal infection. During embryogenesis, may play a role in epidermal morphogenesis together with plc-1.
Subcellular Localization:
Perikaryon. Cell projection, axon. Synapse. Cell junction, adherens junction. Note=Present in neuronal cell somas and axon processes of the nerve ring in head ganglia. Present in the adherens junction of intestinal cells.
Sequence:
MAKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLREGKLDEEDELNETPEVVGEDSVSPRSGGSGGTGAPEEVDDDTSDDDDDPSVQTSLNVMRTIPTVNTTSNNGSNRSARSSLDTPSPSGGSLMVPDRATSTATSIKNAVLARSPNFSSLRQKLSFKRRQSPLAGDQRAHPEVEQPVSSSSPATPSISGPPPCATSSGSTSSITITTTGCSTSSSGPSKHILGGEMPAKENDEAHPELKQNFIAKNLKGFGFSKKQPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDPFVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDVPNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASSTIRSPNEQPQPVAVDKFKVDPIEVDDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQKQQPARRRNSSIAWIQTNVDKLITNNRRSTKKEKGSRRSLTASVSSGCGSASGTVTVSVCSPSGASCSGYSTGGPSTPVACNSDGTGSPATIGSPVPQDLVNNDRVRSLVNTQTGEWSAMVRRHDEEEFELKKVQLKEQFDLLRKLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQKHEEQLTKRHLDQLEQLDKDFHKALDAEVGNYKEEQLAAQPTSVV
The following text describes a protein:
Function:
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Cytoplasm, cytosol. Mitochondrion.
Domain:
The N-terminal region is essential for activation of the IFNB promoter activity.
Sequence:
MAVGAPGILDLLCRMQKEQLLNLKSISLSLGQPAGHLLQVGVLLALGQDMEARIALEALREDRTALAVATAWVNGEDVSAPEDEVDVQLAVASIYRLLAEEHLCGKAGRDSFRARSWVRGKAQHAHDPGFNPEEPGGFELLKSDVGDSQVLPFRERSSPRSIPGVQPGRGTADASPRTLRSLGTPASFIGSLEISQSPTVPYFSTPPRQAPPRQPSKLCDGPVAGSNQVPEGGARREPEGTNRPPEGPPPAKPSLPDPRTLPPGAASGPRCPAAERRRPTPGTGAAGDLELSGEDLPRHQLASTPGPVGPSPLSPPASLPPSSPSAPDPSPLLPPSLSGPLPAVDPRPSSLPGDGERRFFSFVVLHAPGDEAIALRVQAKLERLGVPDGATFCEDFLQPGKLELSCLQEAIDHSAFTVLLLTDNYNCRQSLFQVHTALHHSISRRDKRDSVVPFLPRESQRRGSEVLALLSGLVPLDERSPVFQRKVTRTFTAQRLREQRKIWSQEQAIRVLQERSLRLEEERRREAQRREAEDGYLRQRSLRERVAGMSLEPQLNPSLAAPATPAAPPGHPPVQPFVPQEPGATQPLIIHNAQMVQLGLHNYMWGRGGPKEEGPWGGLAEGQGEESGDGPAGRPAGPARDLV
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTQTQFQVVILATDKACGNSRLSPIDDNIPHSLLPIANRPLISYQFEFLEKAGFETKSDNPIIIVVNEASEEKIRQHVSEIYKGLEVEFFVLKDRLASCEILYRIRDKIKSEYFIILNANLVLEETFIRQMADIHRSGEAAVTMLLKPAQKVVEQPSKKGAAEAPSSSKKELIFTDYIALDEKKEKVIMMEPGTEIEENLQFNKSLLKHFPNLTIYSDLQDTHFYIFSRWVLELIVEDQKEKYPLFSDIKKHLIPYLLSCQIPNIKRQRPLPESAFNLTQKISQEMSSTASPFNQFSDINIQKKKTIKCLAYILKNGYCMNVNTVKSYQQINRDISKGDLSLLPLEPKLEKNYFIDPAANVTPTQVGPYCVIGASSTLGSKCSVKFSIIGKHCKIGDNVRIENSIIMDHVNIEDKCTIKDSIICNDVFIKAGSSTVGQYLTK
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MYFSSSLQVSNAWATQFGLLLERKSFLSYREALPTLFSMLHPLDEIAPVVCRSGGLIQGSCVQYACDSTMKVLFTSSQPSMVVSYDPMQGTHSVWALRKVTHDERSTVLRYPTEPGGTLLGLMASGFLTSHLRNTSRLDSPGGCGAAGGPGTGSSILHSHQSRIVTSSPGIHSRVHSPNISNMAALSRAHSPGMAAPSFTGAARFSQSFNSPNSRGHHGCLPSPNSTLNESMLVPEMEPIIPNLCMEQLWSETVTAGCHREMSSQASKVFITSDLCENHYLCFLVESHQQLRCVKFIESNDSSQLIFPFVTAIPAKDAEPLEVSKVFVPGLLSPSFSLSSQTPHLSTPLENVSTPANSSHRHIQRLEEVPAYAAILLFGFANMLLDFFLLSYELKYGSLINLFLYVYVIFSEVLVKWYNIYNAPGGPSAHAEWNQFVTCFMALMGYNTERLSWTQHLHFEVPLSPVIAAKKARPSDGGSDEDWDYLMASHYHQQMTSQSACGAAETSGAKNSISTDTDSLSPLDSSALLFPHIPALFYVLHLLYQELQLDELHRARAASLVCLLQQLARDLQMDEYLDLYWRDYPSLISCFTESCVIDQALIGQMQHPSSMSSEPPCIFSWLSNCLRGVKNPPFPYLPGICQRTRLLVLSYALYVNGDENATSTDVSKYIVKASADQLLHVVCLCLWQGFTLKDLESVPFGVALPIREAIYRCREKPRSDWSEEVCLLIGRQDLTKQAHNMTLAKTKPVRLSLEPPATTEADEEEDGMSDIIQEVTGLIWSQDLRVQEVRRLLQSSRPVRVSVVQLPEVSDHEYIEEKENKLLQLCQRTMALPVGRGLFTLFSYHPVPTEPLPVPKLNLTGRAPPRNTMVDLNSGNIDVPPNMTSWPSFHNGVAAGLKIAPASQVESAWIAYNKPKTPELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSSARLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVIGIGLVYQGTGHRHNAEVLLSEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMTDLNVPEQLYQYMVGGHRRAQVGANRERHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLKPPDTWFLLDFIKPEFLLLRTLARCIIMWDEILPNTEWVKSNIPQIIRENVDPSEDINMDAMTQAQDYITAGACMALGLRFAGSANSDAFDCLHEFAKTFMKIMAFAGTTSYYNLQTGLSMILLAMSMIMAGTGDLKVLQLCRFLHKRTGGEMNYGFHMAHHMALGLLFLGGGRYTLSTSNSAIAALLCALYPHFPAHSTDNRYHLQALRHLAVLAAEPRLLVPVDVDSLKPCYVLLEVTYKDSKWYKETTVELMAPTLLPELHLLKRVKVKGPRYWELSVDLSKETQHLKSILSRDGVLYVKLRAGQLPYKDDPQGWKSLLATAINHLNSGVRAFKVNSLESDGIYLFYYFLLQKEDTQLLFSAMLYECVTKECPEMLPTYIAIEQAVTAMRHSDVQQTFPLWQLRLVIEFWDSRMLRSPGNCHDTLLTSEFLPVMKNAVDVALDSWLKGEDGNVVVRSYMRGQVPSREAQSLMLACFLIYRSIPFLKSSHTQLEGKSNRCSHKTVQCCLLHAVAVALWRSVGYFNSTIVTRQ
The following text describes a protein:
Function:
SOSEKI proteins locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes.
Miscellaneous:
MISCELLANEOUS: 'Soseki' means cornerstone in Japanese.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The DIX-like oligomerization domain is required for polymerization, edge localization and biological activity.
Sequence:
MAFEENFLSAQVLYQLSWNGKLEHPHIIDVEYASDQGGLRLRDVKERLTRLRGHGINDSFSWSYKRTYSKTFIWNDLSDDDVIHPLCGSGEYVLRASELIDTNERKSCDVHSRHSNKSMQSSPTMLLDNVTSKQDTIIGDVHFGALESGENRRIGDKLNCLVRNSGANLEEVKSLRGVSAVISQSLPTLYADQEIMDVEKSDFCLSSSDTEISPRPKMTVDSIKPVKDVNLVVMTKSSTVHGVHTPPSPSLKSSTELPFSPGGTKRLWEKEIRKSLFRTRNSSNVNSVSTEDFTAVHMELPPNTHSTHEDNSFWRDSRSKSPSPSSLNELKEVQIDKEEVEQSTSQLIRLLWARWTGGSSKGKRIPYNTCEGASTKIPESKHNSPYRTKSPYKEIRSTHVEGSHQETRQSLAVQSKARVSLEIKEILPPEECMHYPSPMTVQNVTEVASPHAQTDGGGDVCTIKTIVSEQASQPYPEPRDLRTDQGILSEKTPGLHIAVLEGLTSDAPSGPAEAEVDTPLPAVARAKTGNTLSKLKTIASSKPLPPGFHKGTNDTKPVQITPRRTPRNSIPLASPPLVRSFSRDAVRGFSSLAAISLCPDKDSVACTPSPEKTIVKKRINYSAREEMPLVPGLTTLDWEKALQEATTDCLPPPNFSDILQECSICRRTFKPDSLQVHMRGCHPPQYARAFSARASPHVVRC
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Subcellular Localization:
Nucleus.
Sequence:
MEAERGEQNKEGEVNVLDDILTEAPDQDDELYNPESEQDVNEKKGSKRKSGRIDMTENKRQKPSSHMSRQPPQRVASGANKKVISTKGKPVTEYKCDDFHRQDRNRKSDGDRRIRSSSGTVRDNYKVPQDKISLRKRESDRSDRRPKSSTPDIASEKIRPDTSRRQSRSSHSSNEGNSDDYGSDRETGSSESSDEEQGNNSENDEEGMEEEEEDDEGEEAEEGEEEYDRDEHARDQRDGNDYDTRSEASDSESDSASFTDGDSVRSGSGSDISDQKKKERKRARGISPIVFDRSGSSASDSYAGSEKKHEKLPSSVRDVRKERTNKIRYILQEARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNAAFRSARSVILVFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMNAKMLGGVFKIDWICRRELSFTKCVHLTNPWNEHKPVKIGRDGQEIEPDCGTQLCLLFSADDSIDLYQVIHKMRHKRRMNSQPRSRGRPSRREATREVGRRQPEEYDIHNRKKPRIDYPPEFHQRPGFVKDPRYQEVDRRFTGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMQPYPAIEQAPHHPYYQHHAPPPQAHPQFSGHHPVQHDARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERERERERERPRDNRRDRGRDRDRDRDRDRMRDRDRGDRGDRGRYRR
The following text describes a protein:
Function:
Binds to ss-DNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MNSLAIRVSKVLRSSSISPLAISAERGSKSWFSTGPIDEGVEEDFEENVTERPELQPHGVDPRKGWGFRGVHRAIICGKVGQAPLQKILRNGRTVTIFTVGTGGMFDQRLVGATNQPKPAQWHRIAVHNEVLGSYAVQKLAKNSSVYVEGDIETRVYNDSISSEVKSIPEICVRRDGKIRMIKYGESISKISFDELKEGLI
The following text describes a protein:
Function:
Essential for magnetosome formation. May bind magnetite (Probable). May be involved in an early stage of magnetosome nucleation (By similarity).
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 20 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Magnetosome membrane; Multi-pass membrane protein. Note=Tagged protein forms straight lines extending along most of the cell associated with its inner curvature, in the correct position to be associated with magnetosomes. In a mamK deletion MamI forms a linear punctate pattern, suggesting it is associated with magnetosomes. In a mamE deletion MamI forms a linear punctate pattern. In double mamJ/limJ deletion MamI forms a linear punctate pattern.
Sequence:
MPSVIFGLLALALGLLGVTAWWWSVTEFLRGAVPVALLILGLVALASGVQSVRLPRSNKGTASDPDIDG
The following text describes a protein:
Function:
Involved in the biosynthesis of the osmoprotectant glycine betaine from choline.
Sequence:
MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKALLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGLVAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVTQWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTMKFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAHAMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAKASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYKRCFNLTPKTV
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MADVTASVDQSTVSDRGQNASPETVDDILPIVFQCLSCQVILGDSFSWVCADQDLQVVVLSAVTSNVSIEEGLETSTDGQDIGSLKIELNKNRTAQTYSSVRQLILGNPGCQGHSTFIPLRCKSCKSGIGRIYRTTPLELDMIRDVFSLDCSSIKSYELGTQAGKNSYKTADELLDIPTAKDLKNEILKVRNTNLHPSIRKRLQNWLDNAPFTLDETQTQAIYKAATFVEINTPQLLITKGSDPVGIYIITCGEAEVVSLDPSSYHHSNQGPSNQNSNPELNQVQSKEYVIRAFTEGECFGEVSVLYDIPCIANVRVPSQASLILLRAADVQGILTPPLEVPMLRLCSIRRYLDTAHLFEDQALSKMVALDVLREVPVLHGWEEAAIKDLIKAMKQEIIVLYPCGSAVYREGDPGHEMYVLVHGRVGLFAEGHQLAVFDSGDKRGFTFGEEGFFTDKEKRCTIKALTPCQIITLKKHHFYDILNQYPNEKVILQVYNEKWKENLSKRDQELYEKYGGALDLEMLRMTLRQSAFFKDCPPGFIYIIALSMLVREIQEEQAVLSHAQYKKGTLKHSTTLKQQLGSMIVRDTLFLLLQGEAIVTEDHDDLFLTVDVKQVFHKASSLPEKAWVKATELSIVAYFNTAVISEAKMAYPDTVMPEIL
The following text describes a protein:
Function:
Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (By similarity). Associates with ints9 and ints11 in the cytoplasm and blocks the active site of ints11 to inhibit the endonuclease activity of ints11 before formation of the full integrator complex (By similarity). Following dissociation of wdr73 of the complex, brat1 facilitates the nuclear import of the ints9-ints11 heterodimer (By similarity). In the nucleus, ints4 is integrated to the ints9-ints11 heterodimer and brat1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (By similarity). Also involved in DNA damage response; activates kinases atm, smc1a and prkdc by modulating their phosphorylation status following ionizing radiation (IR) stress (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Present at double strand breaks (DSBs) following ionizing radiation treatment.
Domain:
The BRAT1-like motif mediates inhibition of the endonuclease activity of INTS11 by forming hyrogen bond and hydrophobic interactions with the active site of INTS11: Cys-821 coordinates one of the two active site zinc ions of INTS11.
Sequence:
MDGDCSSLLPAVCLVLADPKQTPPDDTSLEKLLDWFKDLHSQSNGQVLLEHQPCLLEFISSVCASKATDPAILSFTLKLTGLLAASKQDFHLLEEGGHLVCVFEREAWSVCDLWEDASVRSGWIQGLLNMLKHQQALDFICRQGLIKVILQLQNDRSLFVACLANQLLVQILKLLTPSDVTSGSDAVVSSKSSSSLDWVSVSSEITNAVVEALSSENHPQVLQGVQLLSLVLSQCEEPIRSSLWKDVLPPLEVLINRGSEPLTQPLMTVLRAAVMTPLLGQSEYKVEEFLEVMLGTGNRKEGILCATLIVKLEKCPKVLKRKAMDIILLPLQCVSTQSQDEKEVDLVLKEPLSQKALCISLLVQSLSSLAELAHKEYFEGVCIPSVTSRVVQLLRVCSGHCTSSLLHVSACTHLIGSCKIQRCGLDTLGALSVYEDNLDLRKDIFGVLLDYLKSPDSHATVLKKTFQAVLRWIGVCASFPDLLQFISNDLFPVLEKRMCDVRWEVRDSTLEFITQLTVALSDNSGFVEVLYTSGLVSILLSLLSDTEGYVRASAVTAVGEAVTSSVQQMALVSKINLLEEALAQMMIILSQDTEGFPRRAVVKTFTSWLKGSNPITALDSSLSSVLSLGGNDFDWEVKMHTLELAEALMEKMLTCCPYAVQSFSSSERTRLTQSLSKLKDLGLFDVLLNGLFDCDRPVCEKSCQLLLKLKRLNAEKADFDHDALVLKACGNRWGDEVQSRFLNKQQVKASEHVLIGGGEGTEKDLHCIKEIPLSVILQILDLDDMQRMLKLSSDHVVNSPRSLMEDILSAAQQSEENIVDCY
The following text describes a protein:
Function:
Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVAINDSTDSSFFKENPKIFKDEHELLRYIVPFKNWVIGRPDRKEYAIRNGAPKLLLNLFSLENLSMNEKYQVFVVLNSLMSEDQDPFVQFLRHEDLLSVMQMISKRDSTPYGMLNITLKVFNTMLSFDKAAEYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKVGDSPRFCSALFQITNRATQLRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQMIVTPILIRLFFESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSVCFNLPATKKEQKNLILESVLLAVAALTTSKDEYRKLIVDAKYLPVIINALKINSNSVKKAACECLLSLSRSVYILRTGLADADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELCNDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELRDSILRQTKLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDLQEDDFDREMRPPFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSPSQEDKERASILQNLGFGECLQMLQNHSSPDVRERVKDALMYINVTD
The following text describes a protein:
Function:
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
Subcellular Localization:
Cytoplasm.
Sequence:
MMRTHYCGALNRNNIGQDVTLSGWVHRRRDLGGLIFIDMRDRDGIVQVCFDPKYQDALTAAAGLRNEFCIQIKGEVIARPDNQINKNMATGEVEVLAKELRIYNASDVLPLDFNQNNTEEQRLKYRYLDLRRPEMAQRLKTRAKITSFVRRFMDDNGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFLTAPEVREIMERMVHGLWLDTIGVDLGKFPVMTWQEAMRRFGSDKPDLRNPLEMVDVADIVKDVEFKVFNEPANNPNGRVAVIRVPNGAEITRKQIDEYTQFVGIYGAKGLAWAKVNDINAGLEGVQSPIAKFLNEDVWKGLAERVNAQTGDILFFGADKWQTTTDAMGALRLKLGRDLGLTRLDEWQPLWVIDFPMFERDEEGNLAAMHHPFTSPKDFSPEQLEADPTSAVANAYDMVINGYEVGGGSVRIFDPKMQQTVFRILGIDEEQQREKFGFLLDALKFGTPPHAGLAFGLDRLTMLLTGTENIRDVIAFPKTTAAACLMTEAPSFANPQALEELAISVVKAE
The following text describes a protein:
Function:
Transcription factor involved in the regulation of fermentation and aerobic oxidation. Acts as a repressor of CYC1, which is involved in electron flow through the mitochondria under aerobic condition. Required for pseudohyphal formation upon nitrogen starvation. May be involved in viability at stationary phase and aging.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQSTVPIAIASNGNKRDVVQNVSAGDEGDILQRLARNREMISTSLSPQKSSGFSGRRRSSSVRDALSSFFGTGNSPTSSMDDYSNLMNRNYSTASTAMCRGNSFPSDVGTKAYNITGSYQPDRHRNSVPYTTIDQLHTRQDTGLRRESDPVAAKQISSNNDIVRSFITHHASNSTMFINRVLSDYLADRGFIKQTPLYNKKSVLEISIATSAESVFLPTTKSDETEYLSLIHGSLNQARTQPVGSTNTAESDFLPSCPTMDTLNENNDLSLFPLHTQRTSPSNTARTGNAMDTSNSDRASPASNNNTTDADSFVASGNNNPMNNNNSPARNRHPNSHSRSLPNAWNSQMPSFSFALIFSLNKSTTLSDIKVELTSNVRVVWFNGLPPTKNVNEECYNIGSLDWTLNADNFNLFIPQGAKSPLDIVENHSNNRKLKVLQKLSMRKRRSFSNKAVLRENILNNLNASNSTNKLNAGVYVFTIPIVLASRIPESLYYPSARVSYSLRLATKLKDEHTQLVASRPRSSSISSPQKLRSYSCSDSYEYSQIDDTIEGETYNNDKNSTGKIAFPSSWLKSAKGRLKRNNSNGRSDNNGASSSGLAMQHDSEDTINLQYPLNLVRTPPEISVTTANKPLYINKVWENCLSYEISFAQKYVPLNGEIPITIKVAPLVKSLSVKRIRVSCREKISYRSKDYQYDFDQLDPLASDPCNPYHMRYLVRKKKDRSLPLFEVASKCTSGPSIREEVVTNTVDDNLLAYTSSKENNKDIPFSESFTVKTKLKFPKYCEVDATKAASLPPYGIDLFDPIKDPTQSENTSNNGNVLGFLVGRPNRASKTVHKIPQDKNHNEVNDTNGNSNTSLQTSSNVPIQHYTRLNKPRRGLYLDSMHFKNIQCSHKLEIVLRVSKTDSGSSKIIRHYEVIVDTPIYLISDLCNTSNIDLPTYDMATTESSKVLPPTFEEATSVSASPRSSVSYYPDDISMQQLNLSRSTSLANGYLSTLHPKTTAVSDSSNGAPIRDQQEQQARPLRTEDYALQMGNENNAYSNMDGLLSQDIFEQETAATLFKRDIVTMNFNNNIFTPRYSPRTFTNTDYNYNDNDNNDNDTEGPGPIIHPGPEPPRYDEISS
The following text describes a protein:
Function:
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Subcellular Localization:
Nucleus.
Sequence:
VQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELEGENKIPATQKS
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MPPKNKEKGKKSGAQKKKKNWGADVVAESRHRLVVLEKELLRDHLALRRDEARRAKASEDQLRQRLQGVEAELEGARSEGKAIYAEMSRQCHALQEDMQTRSKQLEEEVKGLRGQLEACQREAAAAREEAEQALGERDQALAQLRAHMADMEAKYEEILHDSLDRLLAKLRAIKQQWDGAALRLHARHKEQQRQFGLTPPGSLRPPAPSL
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLRLAPTVRLLQAPLGGWVVPKAHIYAKPARTPTSPTEQAIGLSVTFLSFLIPAGWVLSHLDHYKRSSAA
The following text describes a protein:
Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.
Sequence:
MEKEKVDELPPNDNWYETALPKPPVPSLEATLDRYLEYAAVVAVGQKASLATTHDAAHKFVRQATPLQEQLLEIAEKSPNWATKFWLPEMYMRVRMPTPVNSNPGYIFPKVKFETKEDHIKYTALLTRGLLEYKNLIDTKQVCREKSTGAQKLQMCMEQYDRVLSCYREPGVGEDTQIRKQKTNDGNEHVLVMCRNQTFLLHSRINGALVSYADVEYQLAQIEEISKINQNNTANIGASGVGPRDNAALFWQDMLTVEQNSKSYEWVKSALFVVCLDMEDPIDYGKNDTMSISEKEKEFVARGYSTLTGHGSSKFGLNRWYDATIQLVVSSSGVNGLCIEHSTAEGIVIINMAETAIRYAQKYFKSKMVWNDVRNVHPKSLTWHFSENSRNILKKQAEVFDELANELELEVLIFNEFGKDSIKNWRVSPDGFIQLIMQLAHYKTHGHLVSTYESASVRRFGAGRVDNIRANTQEALEWVTAMASKKESKERKLELFKKAVLKQVKVTLENISGYGVDNHLCALFCLAREREETTGEDIPSLFLDPLWSEVMRFPLSTSQVTTSLDIPDCYLTYGAVVRDGYGCPYNIQPDRVIFAPTAFRSDPRTDLQHFKKSLAGAMRDVKELLSN