lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
Sequence:
MPPSPSDLESRPTKITKMDDSMDVADAVTGTAPVPSYRPDAKARRYDRQLRLWASAGQRSLEQARVLLVGCDAAGSQSLKNLVLPGISQFTILSSKITTAQDVATNFFLHPDSIGSNIAQESVKYLQELNPAVKGEAHMEDPALIIKTNPRFFLSFALIILSNVEPYLENQIAEILWEASSSVDGPDIPLIAIRNSGFISRVQIQLREHTVVDSHPDTTHTLRIDQPFPALEQHARSLDFANMDSMEHSHIPWVVLLVRAASLWKESHGGKLPETNEEKAEFKEKLKAEKIKEDEENYDEAMAQAYRVWIKSELPWEIKCLLDDETVKNISTNSKNLHILLHTLSQYIIPAPHLPPTSPSLPDMHSSTAHYVALQNMYKAQYQADLKQFKSLLNEVLRNIGLPTDTVPDEELEGFVKNVGGVGIIKGTPLSDSKNIRGLLPTELENFDEEIDSATCLSMYLALLASETFFESEKRWPGASSLDNLAADNEKVQQILLDLFPIFSEGLPEILEQSVEEVIRGGFATVPNTAAFVGGIVAQEAIKLVTNQYSPLDNTVVLNLIKSESSKFKF
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSQPVTPRRTTRSSASASPSPAPASPTSPPKSRPKPSPRRQLLAAAAAPPKEDGSSADALLAELPGRRAQAMDILRLLAPAPALPLMLHGGAATGKTRALLLALRYLRPSQRLVYAALRSLPSPRALFASLLSQLSATPFSTSSRHRVPDKPSDFVAALRDALNGIVSQGEVVYLVFDNLEVVRSWDKGGQLLPLLLRLHDLLQLPQVVLVYVSSATPDAYYSMTGSVEPNYVYFPDYTVDEVRDILMHDHPNPKLYSSFLSVALKPLFRVTRRVDELSAVLEPLFRRYCEPLGDLKAVPDEGMKRRLFEHVQSHLAVALNETFNVPMRASMDEIKDGGSAGKGSAKRQFAGKDGLSSELEFHMSVSAKYLLLSAFLASRNPATLDAALFDSTGGLDNRKRKRKSSQASMHMKDTIVEEMLMKGPGTFPLERLLAIFQCITSVSEDILDEIDCPGNMASESGTTGLMSDVLLQLSTLCNSNFLSKSRSCPLEGSARYRSNIDEDLALKVARSVNFPLSKYMYRR
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIFPAGRDKIWFDTGVPVPEVSTGEFFSLSESILLRIEQLGGLFIWTHTYSLMQKSGKLYHKMQSKSIQCPVDSDEEHEQAKEDGPAGCADEEAPLPTSVKPREHEHGEEEEHQMVSNFTAQSTASSAAMHGHGGILGETDSPELQEAPLLSCESEVADKGFWTKLKDVIHQFIDELMAPPTISAIIGFVVGLFPWLKSIIVGDGAPFKVIQDSLQLMGDGTIPCITLILDGNLTQGLRKSGLKRVVIVAILCVRFGLLPLIGIAIVRAAYGLGFLSRDPLYCYVLMVQFVVPPAMNIGTYAHGTLRNLVKIVNLHTNKVSRILGKVENNEWFLRIALYQGEKGNKKVRKIPSVAANVNDSKEPLSDPTLLCCAFKKHRIYLFRYDVQTGDPLGDGTGGQSIWGTEFEDEFHNG
The following text describes a protein:
Function:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGTSGLICAFLLASCCCCRRVAGVPGEAEKPAPELLEVEVGGTALLKCGPSHSQSNFSHVDWFSVSAPEEGSRGGRQRPRPSRSPRTLTSSPQVHKEKPTLIFRVRQGQGQSEPGEYQHRLHLQDKGTTLALTHITPHDERIFLCQGKRPRSQEHRVQLRVYKAPEEPTIQVNPLGISVNSEEPEEVATCVGRNGYPLPQVIWYKNGRPLKEEKNRVQIQSFQIVESSGLYTLQSVLKAQLAKEDKDAQFYCELSYRLPSGNHMKESPEVMVPVFYPAERVWLEVEPEGMLKEGDRVEIRCLADGNPPPHFSISKQNLSTKEMEEESTDDNGILVLEPAQKEHSGLYECQGLDLETTVSLLSDQQELLVNYVSDVRVSPAAPESQEGSSLTLTCEAESNQDLEFQWLREKTGKVLERGPVLQLRNLKREEGGGYRCVASAPSVPGLNRTQLVNVAIFGSPWMTLRERKIRVKENTMLNLSCEASGHPRPSIIWNVDGTASEQDQDPQTVLSILSVLVTPELLETGAKCVASNPLGENVTSIILELDSNRTNSLSTSTFSPPARANSTSTERKLPEPESKGVVIVAVTVCVLVLAVLGAVLYFFYKKGKLPCGRSGKQEITLPPSRKSEFVVEVKSDKLPEEMGLLQGSNGDKRAPGDQGEKYIDLRH
The following text describes a protein:
Function:
Heterogeneous nuclear ribonucleoprotein (hnRNP)-protein binding the poly(A) tail of mRNA and probably involved in some steps of pre-mRNA maturation.
Sequence:
MMQQPGQGVVPPSMAPPPMDPQQQQPPPQQQPWMMMPPQPHPQQPLPQPVNPQASHMWNQQPQPQPQVQPQAQAQPMQVQYSMQPASADEVRTLWIGDLQYWMDEAYIHSCFAHTGEVLSVKIIRNKQTGQPEGYGFIEFASRATAERIIQTVNGTTMPNTEQSFRLNWATFGGGDKRSEGTDFPVFVGDLASDVTDYLLQETFRSHYSSVKGAKVVTDRLTGRSKGYGFVRFGDENEQLRAMTEMNGVFCSTRPMRIGPATTKKTVGVQQQYPAKGHWVLFDFASVLIFWSFCFHSYTFEEKPPYVASDAKRLCPLRGLEQISAETNVSFSAWHRLAPYQSNPQASQSESDPNNTTIFVGGLDPNVNDDILKQVFGQYGELIHVKIPVGKRCGFVQFANRACAEEALLMLNGTQLGQQSIRLSWGRSPSNKQDSSGSWPQPQADPNQWNGGAYYGYNQGYETYGYAPPPQDPAMYAYGGYPGYGNYQQQQI
The following text describes a protein:
Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MLDRHCLYIGIFQLIIWVGVANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWATSQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGYPDQSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSLEWLQVAFILLRNSPREEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQPTHSAQQTQKYLESRVPGKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGKRHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGSGGEGTVRDLRVSQQTWLDYKSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKNFEGDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKRIGNIWMHSGYQEFRRPCNLTSDSYKSLAYRD
The following text describes a protein:
Function:
Has glycerol-3-phosphate dehydrogenase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MAGKKVCIVGSGNWGSAIAKIVGSNASQLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAATGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGIDEGPNGLKLISEVIGESLGIPMSVLMGANIASEVAEEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGSVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKFPLFTAVYKVCYEGQPVGEFICCLQNHPEHM
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIEVGKTRVKRASNQLFRFGQFCAICVPKITSTNNEVPRWYICYTIGVIITIGCLCIWSIFNKWNQFRSYSNFSVFLFDIITIVTLTSTSILLIVNAVFVKEKRIRTLLIKLSEIKENTRLAEKQARISILELVAVHLVLAFLYSFDLFANGITFGWHTYIFDVPNFVNEYVQAIEVLYICSYTVLIRNKISNLNTSLIHSTHLNGDIVKEHQNLHNKICNLIDEFNECFGLQILGILFVGVIYTTYTIFLLLIFGSGSATPENNVSVVYVLILYILESLLYMIFGIMITKACMSASNLIQRTPNICYKLLSNLGIFPKTTNEQLLRKELLLFAEQMGQRQVAFKVGGFLNIDYGTLYSLFGSTAMNVIILLQFQKQGKYN
The following text describes a protein:
Function:
Antimicrobial peptide active against fungi, Gram-positive and Gram-negative bacteria. Inhibits growth of hyphae in the fungi A.niger (IC(50)=3.5 ug/ml), B.sorokiniana (IC(50)=1.8 ug/ml), F.oxysporum (IC(50)=5.3 ug/ml), F.graminearum (IC(50)=6.9 ug/ml), F.culmorum (IC(50)=6.9 ug/ml) and B.cinerea (IC(50)=13.7 ug/ml). Has no effect on spore germination. Destroys spores in germinated conidia by disruption of cell walls and membranes in A.niger and B.sorokiniana. Causes vacuolization of germinated macro- and microconidia in F.oxysporum, F.graminearum and F.culmorum. Strongly inhibits growth of P.infestans on potato tubers above concentrations of 3.4 ug/ml. Inhibits growth of Gram-positive bacteria C.michiganensis and B.subtilis and of Gram-negative bacteria P.syringae, E.carotovora and E.coli.
Subcellular Localization:
Secreted.
Sequence:
KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKLPAHRCICYYEC
The following text describes a protein:
Function:
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MSLSRMVPAGKAAPRLVVVSARSAHHAHSAAPAASTRPEELDNPNFFQKISLRFQGIPLKGETAPPKSMFDDCGKEWSAPQPLPPVPADFKEHPDRDLTNFPYPSRPMYAPKTRMLMIPDSWLTPFHKVTGTSGPYLFVGGLAAFLVNKELWVFEEQGHMTVGWILFYLLISRTVGFRLDQWLYGEYQNRMGFFKNLIEEDLKEAKEFRKNSALESDSLVAVKEAFPTIFKENMVLQLEATYRKNVQTVATEMKRRLDYLKETEETKRRFERDVMLKFISEGVEAQAADPKFKEQYINDAISQLKGLSPSQI
The following text describes a protein:
Function:
Uptake of antimicrobial peptides. Required for the transport of microcin B17 (MccB17), microcin 25 (Mcc25) and proline-rich antimicrobial peptides (such as Cathelicidin-3, Arasin 1 and Dro/Drosocin) into the cell.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MFKSFFPKPGTFFLSAFVWALIAVIFWQAGGGDWVARITGASGQIPISAARFWSLDFLIFYAYYIVCVGLFALFWFIYSPHRWQYWSILGTALIIFVTWFLVEVGVAVNAWYAPFYDLIQTALSSPHKVTIEQFYREVGVFLGIALIAVVISVLNNFFVSHYVFRWRTAMNEYYMANWQQLRHIEGAAQRVQEDTMRFASTLENMGVSFINAIMTLIAFLPVLVTLSAHVPELPIIGHIPYGLVIAAIVWSLMGTGLLAVVGIKLPGLEFKNQRVEAAYRKELVYGEDDATRATPPTVRELFSAVRKNYFRLYFHYMYFNIARILYLQVDNVFGLFLLFPSIVAGTITLGLMTQITNVFGQVRGAFQYLINSWTTLVELMSIYKRLRSFEHELDGDKIQEVTHTLS
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MTFKEHEMIHNNPNTQSSSLSFAPWLVLHGSQTPQSESVGRLNSVEHRASEEFHPLSKKATQAVEGSADRPDMTQFAIFSEESKFSIDWRKPQLTMSALPEYGSNFHSEFGPPMMYSKYSNVDQISGLFPLYGAQCQGRIMLPLNLTAEDGPRYVNAKQYQRILTRLKCRAKKKLENFGRARKPYMHKSRHLHAMRRPRGSGGRFLNTKALKNATEVNMKKTGSDGMSPCPTSPQSSEVLQPESRGLNASKVGDNNRTNLTGSEVASLYSPHRLLNNHVRPCVHPHLHVDNGGHDMVMPGKWAPAADSCHDLKVV
The following text describes a protein:
Function:
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
Sequence:
MAATQLPILEVGQPKGHSPQTKPKLYILDYGAGNVRSLANSINKLGYEFEWIKDESDFDKAEKLIFPGVGSFAQATSSLRTSGLHSRLLKYIASGKPYFGICIGMQVLFSSSSESPGSEGLGVVPFAITEFKVEDNYEGGNGRKSVPHMGWNKAWKAWKSEGDEKGTETLMVDDDYYFVHSYAALLPDPSASAPPNEVADFAYTLSRYGSETFISSIRRDNVFAVQFHPEKSGPAGLDMLKRWLDAPVDSLSSSPANPASTSVGKTWQPVNPSPLRAKGNGLTNRIVACLDVRSNDAGDLVVTKGDQYDVREKSSDKAVRNLGKPVELAQRYYLSGADEVAFLNITSFRSSALLDQPMLDVVRAAAETVFVPLTIGGGIKDTTDPDGTFHPALEVAGAYFRSGADKVSIGSEAVIAVEEMLEREARGEPALTGKTGIETISKGYGRQAVVVSIDPKRVYVDTSAPGWLESFPAKHRASLIIGDNATSRTAPQEKGKAWWYQCTISGGRAVRDIDVVQLAQGVERLGAGEILLNSVDRDGSGQGFDLDLVKLVKNAVGIPVVSSSGAGSPADFEEVFRETGTEAALAAGIFHRGEVGIDEVKGWLEGKEMAVRKTALPTV
The following text describes a protein:
Function:
Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
Sequence:
MSDIAQCDVTVANGDVIDAIPTDDDSSDGEVPKVVKPNTEIRAEDLYEVYNNKHADEDRLFRAEFQSMPAYVSSLQPVADYAKLTENKEKNRYKNVITCDDSRVKLSPIDEVAFSDYINASFIDGHDVEKKFIAAQGPKENTLDDFWRMIWEHHCYVIVMITELRELGRKKCEQYWPEDGTMEFGKIRVSLHDVIDYGSFVERLLKVTHSDHPDDIMTSPQEPRNISQFQYRAWPDHGVPKTTSEIFRFRVRTLKAQSDCDATPGPIVVHCSAGVGRTGTYIVLDYLVNKLNNDNNIDVYDVIANLRTKRTEMVQSLDQYVFLHKLAMEIHLFGNTDVTKEDFTSRYTSLESEDPESGKSGFEAEFDKLSLTCPSNPRLGSGTFPDNAIKNRDQDIIPYEHSQIFIRMRPSEQTPPYANASMMQCYDVKHNLIVTQAPMQNTIEDFWRVVIDNYVTHIVMLTPLTIDHVEQCAQYWPINDDSMECGELSVHNDVTIDHGEYIETTLSVSGDQPDHKTTTVTHLRYQVWEDENQPPPDGGAVLINLANLVAKQLNADHDGVRPRVVIHCSDGAGRSGIFCCVINLLERLRRENAIDVFRSVKDLRDCRPLVVRTKEQYKACYDIIKKYITSSEVGEEPT
The following text describes a protein:
Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLNLGETAESRDSLLSAGRRLIILLLLSSLPTCGSTRSGSYLDSSYSYETRSKLSFTGSATRMCYSCMSEDFLHHWKHLQELYYTPANFSDECYHIDHSTNKAKLDVPRREKQCVSCGLGPQRALAWQRIGSNIIRGCISDPLTGSEAWEPQIRLKAPLPPPFAPPIRTHKSHCWTEVATKERVIKAIMVFLMDTQRLKRVLLLGQSIIYLIAFASIYYQIPALYGETGIAPVAAKIEKCVASEPLNCVSPLVFVLSHQLSIKPSTALQIVALFGIFFSISTIAIRPTRHFIFYLVLVLLYLSIVKVGDTFLYFQWDSLVLESGWLMIVVAASGNSPADLMSTYLVRFLAARLMFSSGIVKLQSMCPTWWGLTALDIHYETQCLPTPLAWFAHNQPEWARRLSVALTFFIEIYLPPMFLLPIPMLRAIAAIPNIIFMFAIMATGNYNFFNLHFALLCVSSLEGGYTSAAIRARGLGRRFLEFVVSAAVFGAAAVHWAMMFGIQYDPKTSTVLSKITFSKAEFAKMTKLGTSVFVHVAIVGFVLVFLEFLVTVWKQNKATPAATPEGKSKKSGKGKGEKKTAETKSNGGSSGSIFGATGRNAFFVLFFGSFLFWTSFVPFTQIDDAASNRIPDILREVHVRTRKFEFTHSYGLFRRMTGVEGRPEIVIEGSHAPNGPWKEIEFFAKPGNVNASPAVVLPHQPRLDWQMWFAALGAYQHNPWFLSLVNRLLNNDANVIGQLKDWPFKNKKEPLTFVRAQLYHYKFTKPGSKAWWTRSLQHEYMPVMTKDSPAILEFLAQNSLIATKTYKTGPIDKAIDQLHAQALQLPQNTFVWSTTAFGFLLSLFI
The following text describes a protein:
Function:
Cysteine protease inhibitor. Inhibits cysteine protease cruzipain.
Subcellular Localization:
Flagellar pocket. Cytoplasmic vesicle. Cell surface. Note=Flagellar pocket and cytoplasmic vesicles of trypomastigotes and to the cell surface of amastigotes.
Domain:
The BC, DE and FG loops form a tripartite wedge that blocks the substrate-binding site of target cysteine proteases. The BC loop interacts with the catalytically active cysteine and histidine residues of the protease catalytic center.
Sequence:
MSHKVTKAHNGATLTVAVGELVEIQLPSNPTTGFAWYFEGGTKESPNESMFTVENKYFPPDSKLLGAGGTEHFHVTVKAAGTHAVNLTYMRPWTGPSHDSERFTVYLKAN
The following text describes a protein:
Function:
Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MPSMDSCNYRVTLFYKLIAIIGGSALAFGQIPKCTTTNRIAYFFYCNLTHMPPVNSDTLVLDLSFNYLSEVNSTFFPRLLQLVDLNLGSQQTERLIVKKDSFRNTPSLVKLDLAYNQLLILDSDGLAGLSQLKILFLYYNKLNGSILENDYFKDLMSLEYVDLSSNEITYLRPNPLFYHLYSLDIINLRHNQISSICAGDLHSFERKYFTIMELSHNRFNKWETLGSDRCGNPFRNIEFDTLMLSGTGFDVDKMQKFCGALNGTKMMQLKLDSHGMGAGFGYNHIKDPDNSTFVGLVNSNLQILDLSTGNIFSLKPYTFGNLTVLKLLNLAENKINRIENKAFCGLNSLITLNLSYNLLGELYDYSFEGLPDLTTIDLQQNHIGAIQNNAFKSLEKLNYLDLRGNAMKKVTFFEALIPITYIFFGGNKLKSIDSSYVYSTFLDLSENDLNDLGGLFKILQYPLLQYVILKRNRLSVCYSHFSISKNNSLLHLDLSDNMINLIWDNGQCLNVFSNLSLLGLLKLNNNFLRYLPEGIFNGLESLQTLNLSSNLLTHLMPGVFPTNLDTVDLSKNQLYSPSPKVFLSVKKLDLTHNQYICDCFLLDFIMWLNETNATLLGSPYDTYCMYPPNFLFQPLHILTVENCDDDKVLMPLMFSLFVLTSTTILVLMSTVVTYTHYRGFCFATYKRILGLIIGNEKKEEAADACKYDAYLCYSSKDFQWVQDAFLRNLDTQYCDRNRFRLCFEERDFIPGEDHIVNIRDAIWNSKKTICIVTKQFLKDGWCVEALNYAQSRYFTELKDVLIMVVVGSLSQYQFMKYQPIRAYVKRAQYLRWPEDIQDVEWFLGRLSYQILKENTVEKKPNQASRKPFNHELQNIETIS
The following text describes a protein:
Function:
Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction.
Subcellular Localization:
Cell projection. Cytoplasm.
Sequence:
MGGFAGREPRLRQAPLCTPGLPLCHPGSPARRRRAPPTSMWRGPNVNCVDSTGYTPLHHAALNGHRDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKALLEELTDPTMRNNKFETPLDLAALYGRLEVVKLLLSAHPNLLSCSTRKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGIDVNIKDNRGLTALDTVRDLPSQKSQQIAALIEDHMTGRRSVKDVDKTSTAQLPLLSCTDAIAPKSLGSVEKAVTEPTLDSDILAEEEGPYEALYNAVSCHSLDSTASGRSSDRDSVNKEAEATGARAAGVRPRERPPPPAKPPPDEEEEERVDKKYLPLAASEGLALRPRMQGSAPQEEEEHPYELLLTAETKKLGTTDGRTEDHRQSGGSRSQDSVEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLTVPSQNHPESSQQDACQEASMQLEEPGEQSTGAPQPGILDQSKRAGLSAGLTALASRTYLDALTHTVPLHPAGAEEEDGSRSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDTTMGSRSESLSNCSIGKKRLEKSPSFASEWDEIEKIMSSIGEGIDFSQEQQKISGSRTLEQSVGEWLESIGLQQYESKLLLNGFDDVRFLGSNVMEDQDLREIGISDPQHRRKLLQAARSLPKVKALGYDGVSPASVPSWLDSLGLQDYIHSFLSSGYSSIDTVKNLWELELVNVLKVHLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLISQTSSPLSQNDSCTGRSADLLLPSVDTSRRRHDSLHDPGTTSRAEHFRVQEEPSESKLTLRPPSLAAPYAPVQSWQHRPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHMKKIPTIILSITYKGVKFMDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRTMAASAASMIETKSSKPVPKPRVGMRKSALEPPDSDQEAPSHASVSWIVDPKPDSKRSLSTN
The following text describes a protein:
Function:
May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.
Subcellular Localization:
Mitochondrion.
Sequence:
MLFQSCGLLSALGRIGSRSPVTRGILARAAVVWARDVDGNWGAPTVSRLVTGHLHKCVRPPWTVPLAGRLYCTLPAAPSSHYRLIYTCKVCATRSSKTISKVAYHKGVVIVRCPGCENHHIIADNLGWFSDLEGRRNIEEILAAKGEQVQRLVGDDAVEILLRNAGESATQDGDKTGEAESAGNKLLS
The following text describes a protein:
Function:
Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAVARIDAALPPGEGSVVNWSGQGLQKLSPNLPCEVDIHTLILDKNQIIKLENLEKYKRLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGYVEGLKELVHLEWLNLAGNNLKAMEQLNSCTALQHLDLSDNNIPQIGDLSKLISLKTLLLHGNIITSLRMAPAYLPRCLAILSLAENEIRDLNEVSFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQKFHQRQLMNQSQNEELSPLAPVETRASLVPEHSSPVQDCQVVQESEPVVQVNSWVGISSNDDQLCAVKNNFTASVHTARYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPVSPTVELGLHSLNLGLEDDDTAEESAKGPENQGFDKEEKKAFWAANENSVQMTKSEISTEVNKKDRLLPCPERAVPSAVLKDDSHSPRPFPESLGPSVFHTQPASEETMSETASEKLPCRFLTQKSVALGKDKVALQKLNKAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEHIVCLTDEIRRLRKERDEERIKNFVQEEAVRCLWNQVRSLQAWQKMVDQHLNFPPSDVLPMSSTLVTSQSPLFTQSQEPSSGQNSDWFTAPEEAPQEKFLPEFPDSGFHSSLTEQVHCLRDSLDFEKSSTEGSESSIMGNSIDTVKYGRESDIRDVSEEHSEWNKENSNSEQDNSLLEQYLTSVQQLDDADERENLDEGTGDTKLPIACSPETLDVLEPDSAVDDTQGISPALQDEINQTPESGKLNAVVQGQQSDCESAFQVLHVGIIV
The following text describes a protein:
Function:
Functions by promoting the formation of the first peptide bond.
Subcellular Localization:
Cytoplasm.
Sequence:
MVLKWVMSTKYVEAGELKEGSYVVIDGEPCRVVEIEKSKTGKHGSAKARIVAVGVFDGGKRTLSLPVDAQVEVPIIEKFTAQILSVSGDVIQLMDMRDYKTIEVPMKYVEEEAKGRLAPGAEVEVWQILDRYKIIRVK
The following text describes a protein:
Function:
Plays some regulatory role in both viral DNA replication and transcriptional transactivation.
Subcellular Localization:
Host nucleus.
Sequence:
MPRDTNNRHRSTPYERPTLEDLRRQLQDNLDSINRRDRMQEEQEENLRYQVRRRQRQNQLRSIQMEQQRMMAELNNEPVINFKFECSVCLETYSQQSNDTCPFLIPTTCDHGFCFKCVINLQSNAMNIPHSTVCCPLCNTQVKMWRSLKPNAVVTCKFYKKTQERVPPVQQYKNIIKVLQERSVISVEDNDNNCDINMENQAKIAALEAELEEEKNHSDQVASENRQLIEENTRLNEQIQELQHQVRTLVPQRGITVNQQIGRDDSAPAELNERFRSLVYSTISELFIENGVHSIQNYVYAGTSAASSCDVNVTVNFGFEN
The following text describes a protein:
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular Localization:
Cytoplasm.
Sequence:
MADSKPGVHVLQLKHVSVPPSMIAGEKFVKWDEDSSLVTAVTLRVDPYGYFLYWTDQNEETQILDMCTIRDTRTGHYAKVPKDSKMRDQVTMGASQDSLEDKTLTVSYGPDFVNVSFFNFCSSKKETAKQWTDDLLKMANNLLALNGSVHYFLRKAHVRLTLQADKGGKIAVKNIVRTFAQHRDDRRRVEKAFIESTGLASGKDDAIPLSQFGFDDFYRFYKKLTGRQEVEKIFEELFGTKLHITVEQFVEFLNSYQRDPRLNEILYPYANPDRARDLFHQYEPNAPNAPKGLLSAEGFLRFLMSEDNSIVSADKFDLSHDMEQPLCHYFVNSSHNTYLTGHQFTGKSSVEIYRQTLLGGCRCVELDFWNGKNEDPIIYHGYTLVPEVPAKDVIEAIAESAFKTSEFPVVLSFENHCNPKQQAKIAQYCREYFGEMMLDQALESHPLEPGVPLPSPAQLKRKIIIKNKKKHQHHRTLKDHRQDQSSLTLRLFLSDDEDESSTLSNLSPEEIRLREKAQKDKGTAGKETEAGAEISALVNYVQPIHFHSFEHAERRNRSYEMSSFVETQSTALLKEHPIEFVNYNKRQISRVYPRGTRVDSSNFMPHVFWNAGCQLVALNFQTLDLAMQLNLGIFEMNGRTGYLLKPQFMRRMDRKFDPFAESTVDGIIAGKVSVQVISGQFLSDKRVSTYVEVDMFGLPADTVRKRFRTKTVLNNGINPIYDQEPFVFNKVVLPDLACLRIAVYEDSGRLLGHRVLPVTGLCPGYRHLGLRNDGGQPLNLATLFVNIMVKDYIPDGLSDFANALANPIKYQSELEKRSKQLSILKQPSLEGDTPVPTALSAENIPTKRQDSTKMKTNSILRPEFRDISGLGPSSPGLSDVESESVVVAETFEKLIENKHVKKQRDKLNKKLEDIQKEFEKEKTKLEEELGIITKSKVTKTSSRLIKRISSKNLNKEPATVRSSSETAECLLAQRLPPILQKFNEEKANMRKHYHEIIYITLEKCIAASKEKQLKLLKEQYDSQVGGATKSIHAQVSREFKSLNKRHKDKDELDRMKREKREEIVRKGVVEHERLEQQFEKKEKELRRQYEELQKRFEEERMKEYMSISRESDRSTSVVSDDVFDAAVPLGPACRPHS
The following text describes a protein:
Function:
Required for septate junction assembly, possibly by organizing the preassembly and transport of septate junction proteins including dlg1/disks large 1 and Nrx-IV/Neurexin-IV. Involved in paracellular barrier functions of trachea, hindgut and salivary gland mediated by epithelial cell septate junctions.
Miscellaneous:
MISCELLANEOUS: The name crooked reflects the excessively long and convoluted tracheal dorsal trunk phenotype of mutant larvae. Should not be mistaken for the proteins crooked legs (crol) or crooked neck (crn) (Probable).
Subcellular Localization:
Vesicle. Membrane; Lipid-anchor, GPI-anchor. Endomembrane system.
Sequence:
MKTLEKYILFAIVLCCLLQLGQAIKCWDCRSDNDPKCGDPFDNSTLAITDCQQAPELEHLKGVRPTMCRKIRQKVHGEWRYFRSCAYMGEPGIEGDERFCLMRTGSYNIFMEFCTCNSKDGCNSAGIHRLGLMGVLTGTLLSVIVAHLLRQ
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MADEENKKSIVVASDDECPCDDTEAADQETELSSILDKLSLEPKKEKQKKKLLVLSLSGLLLHRVHQRTNRKTPKNRSPDASCGPNLVYKRPFAEEFMKFILERFEVGIWSSACEKNVDIVLNIVLENLQDNLLFVWDQEECTDSGSATLHNSDKPMFFKDLSKVFKYFKGFSASNTIFIDDEPYKALLNPDNTGVFPVSYDPTDKNDDFLDPEGEFCSYLDDIASSPDVQDYVKEHSFGQPMHD
The following text describes a protein:
Function:
Responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan. O-acetylation of the peptidoglycan is the major determinant for lysozyme resistance. Critical for virulence and escape from innate immune response of the host. Involved at both early and later stages of listeriosis in the mouse model of infection. Required for successful host colonization and for intracellular survival of bacteria in macrophages of the infected host. Controls the production of inflammatory mediators in the liver of the infected host. Confers resistance to host antimicrobial molecules and to cell wall-targeting molecules such as beta-lactam antibiotics and bacteriocins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Secreted, cell wall.
Sequence:
MKRTTRYSRKYVPSIDGLRALAVIAVIAYHLNFSWAKGGFIGVDIFFVLSGYLITNILLTQWEKNQSLQLKQFWIRRFRRLIPAVYVMIVVVVIYSVFFHPEILKNLRGDAIASFFYVSNWWFIFHNVSYFDSFGLPSPLKNLWSLAIEEQFYLIWPAFLLVFLKWVKNPKLLLKIVIGLGLLSAVWMTILYVPGTDPSRVYYGTDTRAFDLLSGCALAFVWPFNRLSPVVPRKSKAVLNIAGTISILCFILFTAFVSEYQPFLYRGGLLFVAILGVIMIATISHPASYLSKIFSFKPLRWIGTRSYGIYLWHYPIITLTTPVLEITQPNIWRAILQVAATFIIAELSFRFIETPIRKNGFINYFKGFKDKNYFIWKNKPVGKWLSIAGVVAVLAIFTLGMSNVLSVNTNAEKQQTSVKTTTSTPDEKKDDKKEDKATKDKEADSNKASEQKETQKPDNKNKSAATPKTIITQTVAIGDSVMLDIEPYLKEAVPNITIDGLVGRQLRDAITTATGYKKFNSENSSVILELGTNGPFTEDQLNDLLDQFDKATIYLVNTRVPRGWQSDVNKSIANAASRPNVTVVDWYSRSSGQSQYFAPDGVHLTKAGAQAYVAMLTSVMNK
The following text describes a protein:
Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Sequence:
MGPAGSAFLLSLLLGENEWEFENDEKMRTRGTGHQELYMPLSLLSLVCGRPVYSGRVVGGQDAVAGRWPWQVSLHFGQTQVCGGSLISDRWILTAAHCLKGWIPFLYTVRLGSIKNDQSSQSVNHRVFKIITHPQIQHTSADIALLKLVSRVTFTSFILPICLPSITKQLKIPASCWVTGWGTVKESEGENGDYPSILQEAEIPIFNHQACEKLYNPIGPALPELESVIQDDEICAGDILNKKDSCKGDSGGPLSCHINGVWIQIGLVSWGIGCAESLPGVYTSVIYYQKWIKTTISRGPWFALWASYLVYIFLHCLIARSQIKNAYI