lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. May modulate transforming growth factor-beta signaling by binding host SMAD3.
Subcellular Localization:
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Host cytoplasm, host perinuclear region. Host nucleus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Sequence:
MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQHGKEELRFPRGQGVPINTNSGPDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRGNSRNSTPGSSRGNSPARMASGGGETALALLLLDRLNQLESKVSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFGDQDLIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTDEAQPLPQRQKKQPTVTLLPAADMDDFSRQLQNSMSGASADSTQA
The following text describes a protein:
Function:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II.
Subcellular Localization:
Nucleus.
Sequence:
MAPLSRWYFTREQLERSPSRRAGLDADKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMVQSFTRFHRNSVAPAALFLAAKVEEQPRKLEHVIRVAHACLNPLEPAPDTRSEAYLQQAQDLVILESIILQTLGFEITIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKPWWEYVDVTVDLKLLDELTHEFLQILEKTPNRLKRIRNWRISQATKKPKEEECEEESDNIFCEQTLLQMFSQSGMLNSASLSDSSSQTLSVTENDGGMSEGQWGCQLQSERDQHRTGEHVTSTEQSQALGSKPVPLAKMSLKEYRAKHADELAAQKRQLEQLGTSLKEQYACAAQNLLQQQKEREKEAHASPIILKIPLHEVSHKRSEKSSSLKLRIPVTNREKSEEGKVRIKLPNEDSSKSRDKHRSSYSSSHHNNQSHRQHHQEPSGSNGSKRSLPPPVVSTHKSSSSSRKRPATEEATGHEPPSHKVSRTSKPSSQEPAVPLLLNRVRGTHSKTERESSGTNGHSITKVIDYQDTVNMLHSLLSAQGVQPMQPPQYLNQFGEFRRTRPGNTDDSRRPPLPAEPPPPLPPLPK
The following text describes a protein:
Function:
May promote cell division.
Sequence:
MAEFMEPNLVSNFDDEKSNSVDTRSIFQMGFPLESEEIVREMIEKERQHSPRDDYLKRLRNGDLDFNVRIQALGWIWKACEELQFGPLCICLAMNYLDRFLSVHDLPSGKAWTVQLLAVACLSLAAKIEETNVPELMQLQVGAPMFVFEAKSVQRMELLVLNVLRWRLRAVTPCSYVRYFLSKINGYDQEPHSRLVTRSLQVIASTTKGIDFLEFRASEIAAAVALSVSGEHFDKFSFSSSFSSLEKERVKKIGEMIERDGSSSSSQTPNNTVLQFKSRRYSHSLSTASVSSSLTSLS
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor.
Sequence:
MGIPSFYKWVVNKYPSIISPVKEEPEECPDRIIYDNLYLDMNYIIHRCFHPQDLMHADIDVCPPMTVSEVFESLFEYMDRLFRIVRPTRLLYLAVDGVAPCAKMNRVRRGRFHSARMATSEEIEDYEMRKELRAQGKEETPQEISEVSDPNVITPGTEFMEKLSQALEYYIRGRFNSDPWWRDIMVILSDANVPGEGEHKIMSFVRAQGNMEGYDPNTRHCLFGHDADLIMLALASHEVHFSILREDVLLPNQAETEGNPKKPFLFLNIWVLREYLEIEFKILDPVCEPDIERLIDDFIFICFLMGNDFIPHIPSLETHEGAVDLLIEVYKTTFNKMGGYIINTDKVKDKNGAYLEVSRLEIFFHELSMYEEKIFLKRYKLEQDLLLKTYHEMLREASESERPELRQKLDDLLFNEERPYDRIRLGLPGWKSRFFREYFGAETSNEIGKLQNDMAQKYLEGLCWVLQCYFADVPSWSWYYPFYVAPFVSDLKGLSRVDISFTVDKPLRPFDQLMAVLPMQSWCALPKCYKEMMGRKEFDYPRLEHDTKGRHFLWNGISEELLLSATKVVDKKLTTHESRRNTTRQEKIFLHRDSSSLPHNEVTEQTSHCSVQKLPIDSATSGIGGWIAPDDNDGFSDGSFHSPTTNLQDITSDQTISGTFFNPEAANPVPRLLRNVSVPDKTVTGADISKRPLWHTYPGSRPPRIIQRPDTIWKPSTPASPREEHKNAGTGWIGRGKGNALATAETHLKSSSNSYRRGGGGSSSRRFDDDGAYSFRPLGSAPWTAGDSSRSGGAGHGGIAQPRGW
The following text describes a protein:
Function:
Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MEIPIQVAVRICPYTEPSENRKPVAGAEADASAFGNAEAKAESFSDSEDNKNDASNRQRPEESTDANGNSEGGRQLKKETLPTDSNGNENGTIVPLGSGCCVQAIPISASALGLPSALPGGRAQDSIAAGLIQVGAHTVPVTHALGSGTTQSQLYYQTVFPLISLFLEGFDASVVTYGQRGQGKTYTLYGPGFECVYGEADQGVVQRCVRDIFAHIAGHSERTYAVNVGFVEICEGEVCDLLDMGNVHCQSVEEVFRWLQIGLATRQPKSAHSLFTLTLEQQWVSKEGLIQHRLSTASFSDLCATERWGEPPPGNPRDAGLQMLELVVNTLTDPSIMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCVSPQEQHVAETLGNLQFAFKVQCVRNYVIMNTYSDDNTPISPETMPNGSSNPGAGPLAQVAAGDNFGLQFAASQWFKLVSNAEGLFAKLMASNLISELEKEQIEEWLFLKQECEECLSSTEAMRSQKQLVPIQEAEEPEESVSEPPNSDNDTDNESQRPDLADKLESLMEEFRAKTDALIQSKHAEFLTKHPKAVMQSQERDKESKLDAPPEKDKEKIEERKTSIAGRRRSIQPGASLSTAELALLNRVALQQPTAQPPPSVLDPESSIDPLESSAGEGLRQAAIAAAAANAPIEQLQKKLRKLHAEIEGRQRQLKEIEQTMQVKQNIISELVKNSDTRSHAKQRFQKKKAKLEAECDKAKKHLAKALIQGREKGETERWSAIIAHIEHRLEDLSSMKHIAGESGQKLKKLQQSMAESRKQQEELEKKIRKESKLRDQLETELAKLKESRDGASGGKELVKLDSPEQQGRQLKAVQARITHLNHILREKSDNLEECAGGEGPAPAQQESLRHEIRNLRGTRDLLLDERCHLDRKLKRDKMLTQREERKLLECDEAIEAIDAAIEFKNELICGHKSIDTSDRLQREKGEQMLMARLNKLSPEEMRTLLYKYFNKVIDLRDSSRKLELQLVQLERERDAWEWKERVLSNAVRQARLEGERNAVLLQRQHEMKLTLMLRHLAEETSASSASYGERALAPGHQTSSGDFDYELDFYKAAATTTTTTNHKALVKPPKSTPSGAALEKYKDKEQRGAGRNIFAKFQVLTRYASSAASAAAAGSCSSTVDESTALIESTTTATATTTTTTTTTTTGGKGKERGLPNIRQDQLKRLMPAPTVTKVTRQKNKIIIQDASRRN
The following text describes a protein:
Function:
Involved in sphingolipid trihydroxy long-chain base (4-hydroxysphinganine) biosynthesis. Can use C18- and C20-sphinganine as substrates to produce C18- and C20-phytosphinganines (D-ribo-2-amino-1,3,4-trihydroxyoctadecane and -eicosane).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MMSFVISDEFLGTFVPILVYWVYSGMYICLGSLDKYRLHSKIDEDEKNLVSKSAVVKGVLLQQTLQAIISVILFKITGSDADAATTQQFSILLLARQFIIAMLVIDTWQYFIHRYMHLNKFLYKHIHSQHHRLIVPYSYGALYNHPLEGLLLDTIGGALSFLFSGMSPRTAIFFFSFATIKTVDDHCGLWLPGNPFHIFFSNNSAYHDVHHQLYGTKYNFSQPFFVMWDRILGTYLPYSLEKRANGGFETRPIKVSKDE
The following text describes a protein:
Function:
Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEPGMLGPHNLPHHEPISFGIDQILSGPETPGGGLGLGRGGQGHGENGAFSGGYHGASGYGPAGSLAPLPGSSGVGPGGVIRVPAHRPLPVPPPAGGAPAVPGPSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV
The following text describes a protein:
Function:
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity).
Subcellular Localization:
Bud. Bud neck.
Sequence:
MSYNLDVDEADVAVLNQNLIRSKELFESIGKSLHKISTKSQTASSTINPVLKQVNQLTTNKHEVENGLKLLQEVSENASKINDLENLLNNSIENSPGGIKSYLINLNQSKNLLSQIKTQSKFKQFKGILYNFENLIDRSETKVQKYYQDLINGKDSRAIIDKRDEIKLIFQYFSNPQTKSTSNSGGNEEYVTKLYVRARSKRLIEKLKPIESSTKPAVKANANIPYEKGTNGITKYTDVLSGEIEQELIILNECQLSTHLIGPIVEESISRYNGIINKYNQVYFKTPQEIVDNVILILEVLNNLIDFKVKLKQIGLNRTLEQSNFINTFEQYLETNSVIFKEFIQAIDNRFQNLGKFNEINTQEVIVELMSKLRRLSEFKLALLQLIKNYSIGQWLVSQPPMRFVNVFSSVIPNSQPQANSDGEEDEVIQEYLLSSFYSDVIDAIMINIEIGLKKNTSGGDSLPSSSSTSASTNATSGTSSLSLNKKSTQGFILIKNLFMLESIVNRSQYLYQSLGSLGEERILRLKNRFLKLFLDDWSHASYIIIRDMTTIATQSAQHQQSQQQSSNTIGTGGGTVTNLSNKEKDQVKDLFKNFNESFEEALFNYQKYNFGDAILKKYLSNEIKKLILNTYFKLYDKYGNSDFTKNKSKYVKYDKLNFEKLLNERL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MNKARGTEVAGFITDAAHIRAALIVLLQHSLVGVSGGGSKQAKDQDVDATPIKPDPTSPSTHYTYTFLVDRARLLTRYPRYIEHAKEMVDENASSIVEFLLVNGKMRGEDVIASVWEVVKGSGVNGVEGEDTEDSDGLESPTKVKSETNADDVLSSPTTNGNKSNDKHEKQDGITGGEVEFEMNDDGDIDTKKKRARSISGDRGDKKPKKQKVANGKSKSSGDDDNREDDYGANKPDNPQILSLLSPLRRIIPPGSVFRVNTSMFHSSIRAIVIGRLVSEMYDTAPTKKGTKSDSDDDNLSHVGAIVRAALTYAARQEHAPMDQLLGMEETEDDKHNRMADWGAFTPNDIIPYLPLEVTAALQSQVGGTVQNLSATLLRLSQFQYPPILTEVEDVGGHPAGGKFEISTRQLLQRMRDRILHRVLTTHHGLAAARIVSILQVKGHMESDSIAEDAMMPAKEAREILHRLHRDKFINLFDMHMTKQHNSGTAIYLWNVIPSRLMNTVVNNVYTAILHLRLRRQHEVEVGKDWMDRAKEAGATEENVHEDDKRKYHAFCKGLDRLDFACLQLDETLMVLKDF
The following text describes a protein:
Function:
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
Sequence:
MIREERLLKVLRAPHISEKATMSAEKSNTIVFKVAKDATKKEIKAAVEKLFEVEVKSVNTLIIKGKTKRQGLRQGRRSDVKKAYVTLNEGQDLDFVGGAE
The following text describes a protein:
Function:
Penicillin-binding protein. Has low DD-carboxypeptidase activity.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKRTMLYLSLLAVSCSVSAAKYPVLTESSPEKAGFNVERLNQMDRWISQQVDVGYPSVNLLIIKDNQIVYRKAWGAAKKYDGSVLMEQPVKATTGTLYDLASNTKMYATNFALQKLMSEGKLHPDDRIAKYIPGFADSPNDTIKGKNTLRISDLLHHSGGFPADPQYPNKAVAGALYSQDKGQTLEMIKRTPLEYQPGSKHIYSDVDYMLLGFIVESVTGQPLDRYVEESIYRPLGLTHTVFNPLLKGFKPQQIAATELNGNTRDGVIHFPNIRTSTLWGQVHDEKAFYSMGGVSGHAGLFSNTGDIAVLMQTMLNGGGYGDVQLFNAETVKMFTTSSKEDATFGLGWRVNGNATMTPTFGTLASPQTYGHTGWTGTVTVIDPVNHMTIVMLSNKPHSPVADPQKNPNMFESGQLPIATYGWVVDQVYAALKQK
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MSFEAGGERPRRGRPSRANAKGSAEVSQTTGVNNDEQRRKLRSSYRALKHTLADGKDELVQSNSCKFEELFDQMESLHQLVEKPREQIADAELFLDITTGLLEVAKGARCKNGMSPAEFVGAIMHNFGGTSIDWNLLGMETGSIFCEAPGVLTMLGPMDIEVKQRKVPVSRKRDRPSQKTRVQEVEEGDADKESCETDVNMLIMFRLLSESPDVELDRLVLNRHSFSQTVENIFCMSFLVKDGRAEIKIKDGRHFVVPRNAPSHEERGCGQGLVHNTQFVFRFDFKDWMYMKQTVQEGTELMPHRGNEEEAVPPSRTVRTPIRKNSRNRARETPSQQAPSEDEDEGILARPRKQTALLSRLI
The following text describes a protein:
Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
Subcellular Localization:
Secreted.
Sequence:
MRGVCVALVLLLLSVCGGALGVHVQVEDQVFPLEAVTQLKELLDLSAFHPGLANAKAASVCDHPLLPQVFHPACQEKGADILFTKLMNIMVSSDPCEICANPSCFGCLK
The following text describes a protein:
Function:
Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD.
Sequence:
MNDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFNVTHKHEIDAAVEHIEKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELARHNIQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVNGHLLFVDGGMLVAV
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTSKESICWYLANILLVTCIGYYSYKTPFTKVEESFAMQAIHDIQTYRWDLSKYDHLEFPGAVKRSFIPSLFIAVLSYIPSWFVNPLLAARWTIGYLSWESMNSVSCSISKRFGTLSGALFILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLLKNNYYGSISILVFAAAIVRSEIALLLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWPELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVYIKPARLLIYVPLFFIFVYSFLGHKEWRFIIYSIPWFNAASAIGASLCFNASKFGKKIFEILRLMFFSGIIFGFIGSSFLLYVFQYAYPGGLALTRLYEIENHPQVSVHMDVYPCMTGITRFSQLPSWYYDKTEDPKMLSNSLFISQFDYLITEDPESYNDTFDVIESVNSNTKIPILPKWLSNHIPREISIRNPAQPVYILANKKARATKPAAVDDYSSFIGHKVDEIKLWPPIYRVVSPDTLLTRDYREDRLNFFIDKDRILTHITQG
The following text describes a protein:
Function:
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MDNDKYLKGTTTVGVVCTDGIVLASEQRATMGHFIASKTAKKVYQIDDLVGMTTAGSVGDAQQLVRLVSVESQLYKMRRDESMTIKGITTLMSNFLSRNRYYPMMVQLLIGGVDKNGPGIYSLDAMGGSIEETRISATGSGSPMAYGVLEDQYRENMTVKEGLDLAIRAIHNATKRDSASGENIDVVVITKEAFKRLDPEEVKSRRALLN
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MKTNLHVIKNIKIYLSISLVLVTLSIVIFFTKGLNYGIDFSGGNLFQLKYNGTTVTLNQINENLDKLAKELPQINSNSRKVQISDDGTIIVRVPEISENDKGKVLNNLKELGSYTLDKEDKVGASIGDDLKKSAIYSLGIGAILIVIYITMRFEFSFAIGGILSLLHDIIIAVGFIALMGYEVDTPFIAAILTILGYSINDTIVIYDRIRENLKRKHKGWILEQCMDESINQTAIRSLNTSVTTLFSVIAILVFGGASLKTFIMTLLIGILAGTYSSIFVATPVVYLLNKRKGNNMEDMFKDDEENNDGKRVEKILV
The following text describes a protein:
Function:
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. If X is Ser, Ala, Met, Cys, or Gln, then the protein is farnesylated, if X is Leu or Phe, then the protein is geranylgeranylated. The alpha subunit wraps partly around the beta subunit forming part of the active site. The beta subunit is responsible for isoprenoid and peptide-binding.
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASSSPSISLPMVSAFEPAVHWRTNNYPALQKTGAVDYAFREHVAGIIIAHAAHGLSVLVLYCLGCAIFSGRKGRMLAFIAACLHIFSPAGLFLSAPYGESTYALLSFTGYFLFVQSFSPSGASTSLKDALIPLAGILCGLATTVRSNGILNGLLFLEEAIRALYSLTGAITFAKFRRLLAVGVAGICTALGFVVPQYIAYRDFCINYPFTGHDEPRIWCRRTLPSISSFVQDHYWNNGFLRYWTVSNIPLFALASPMLAIMTYSALWTLNVESGRLTGAGRLLRSLAAPQLILAALTFSKHHVQIITRMSSGYPVWYF
The following text describes a protein:
Function:
Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation.
Sequence:
MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MALNFWKSSHCQQWIFDKTEIWKQRAEDMKIYNEEEYNRLNIFWANFITAVATEGAHSQANVGCKLRQQVIATAIIYFKRFYLRQSFRDMCPFLVASTALFLACKVEEHTTLSVSSFLKNTAIVLPKRWGVTFETTSTKNGVVYDSEFILVEILDCCLVVHHASRPMFELLEDLKQFTQQSTIANQPIKDLEAIEAQCQKVANDSLRCDVSLIFPPHVIGLSSIMVAMELMGRGEELEAWLVEVDTDFEKVTDCVEQIYKMYTLWKSFDEKEEVKKLMAKLPKPNQQPPPQQQHQHQQGYHL
The following text describes a protein:
Function:
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Sequence:
MARLPSSILDYIAAQQNRHKLRNMTHILTLPIRDSYVTETSELQNATEEQIVACLEKSRDQVRSLETEKHVNFLNMFLSPDAPLPDKFTGLDASRAWLLYWSANAIRVLGGELSDEQKKGIPLTLESFKEDGVFGGGSGQDAHAASTYAAFLALADSDDEDAWGRLINPEEVLKHNLKLKSPDGGFASNVGGETDVRGTYCRLVVASLTNTLTTELTDGVIKYIASCQSYEGGFGGSPGNEAHAGYTYCALAALAILVPIREMDQYVNVESCLAWLSARQYQPEGGFSGRTNKLVDACYAYWVGASLVLINGAVHAGPSLWDRKQLAQYVLNCCQQSGGGLRDKPGCKADAYHTNYAACGIAMSQYIYFPEGENGLYWQATSCDGADTSICPVNPVYGVPLGVAERMRLYFTLKEENLK
The following text describes a protein:
Function:
Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MAPRVAPGGSQQFLGKQGLKAKNPVSTPNSHFRSASNPRKRREPPTIDTGYPDRSDTNSPTDHALHDENETNINVVVRVRGRTDQEVRDNSSLAVSTSGAMGAELAIQSDPSSMLVTKTYAFDKVFGPEADQLMLFENSVAPMLEQVLNGYNCTIFAYGQTGTGKTYTMSGDLSDSDGILSEGAGLIPRALYQLFSSLDNSNQEYAVKCSYYELYNEEIRDLLVSEELRKPARVFEDTSRRGNVVITGIEESYIKNAGDGLRLLREGSHRRQVAATKCNDLSSRSHSIFTITLHRKVSSGMTDETNSLTINNNSDDLLRASKLHMVDLAGSENIGRSGAENKRARETGMINQSLLTLGRVINALVEKAHHIPYRESKLTRLLQDSLGGKTKTSMIVTVSSTNTNLEETISTLEYAARAKSIRNKPQNNQLVFRKVLIKDLVLDIERLKNDLNATRKKNGVYLAESTYKELMDRVQNKDLLCQEQARKLEVLDLNVKSSREQLQYVSKSNQEHKKEVEALQLQLVNSSTELESVKSENEKLKNELVLEIEKRKKYETNEAKITTVATDLSQYYRESKEYIASLYEKLDRTERNNKENENNFWNLKFNLLTMLRSFHGSFTDETNGYFTLLNDFNASMEELLNTHSNQLLISMTKITEHFQSLDEALQSARSSCAVPNSSLDLIVSELKDSKNSLLDALEHSLQDISMSSQKLGNGISSELIELQKDMKESYRQLVQELRSLYNLQHTHEESQKELMYGVRNDIDALVKTCTTSLNDADIILSDYISDQKSKFESKQQDLIANIGKIVSNFLQEQNESLYTKADILHSHLNDTNSNIRKANEIMNNRSEEFLRNAASQAEIVGANKERIQKTVENGSQLLDSKSKAIHSNSRSMYDHCLALAESQKQGVNLEVQTLDRLLQKVKEHSEDNTKEKHQQLLDLLESLVGNNDNLIDSIKTPHTELQKITDHVLKGTTSLANHTNELLGLGDESLCNLETTIEDTSLVKLETTGDTPSKRELPATPSWTRDSSLIKETTNLNLDSDKKFVRETYTSSNQTNEPDVYDKPSNSSRTSLLRSSRSAYSKMKR
The following text describes a protein:
Function:
Component of the KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Pcc1 functions as a dimerization module for the complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPKRVQGKIVIEFPSEDIAEVVYTSVLYEHVSVPYRRSRVNFRREGRRIVLEIEANDSSAMRGTVNSYLRWIKVALDVLNI
The following text describes a protein:
Function:
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGDSVTEDISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDMFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPAPRPPGPRPAPPQQEGPPEQQPPQ
The following text describes a protein:
Function:
Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments. It also plays a role in the assembly of cardiomyocyte cell adhesion complexes. Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Sequence:
MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRVRVTIAYMVGEDALDTLRSSHPGSVTAWPCLTSHLPRRNRHPSPNHRLHQPLTLHRVTGPFSENRLETVRYVLHGNPMSHAHSFKLRGPSLGCQSDVDLSCNDLTRVPECLYTLPSLRRLNLSSNQISELSLCIDQWVHVETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLASLEEFMAANNNLELIPESLCRCTKLRKLVLNKNRLVTLPEAIHFLTEIEVLDVRENPSLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGPKDPLARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESTDARAPGGKTRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGASLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQEPPEFWEALGGEPSEIKKHVPDDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKTRPKVELLPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHASVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQGPGLTGKVKRDAEKKDQMKADLTALFLPRQPPMALAEAEQLMEEWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEEKKEEKEEEKAGAEGKEGEEAAAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKAAQGTLQPSLYQIRTNGSALCTRCIQINTDSGLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHEQPRRLRLVRKGNEQHAFTRCFHAWSTFRKSLA