lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling.
Sequence:
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHFGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNQESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIAVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MASASKNIQQNPFSSKPPRPPYSSGAASTTAVASTSAEPLIRNSTLNPNPSTSGLPSTSNSPITMSQEDEILARSSHITRSELLKRRSHNLKQLAKCYRDNYWALMEDVKAQHRDYWWKYGISQFKDENNQSNKRRRLGQEGDIGDGGDAVEGSGDNVTNNDGVKSDQYANSNCGSCMYGCKAKAMALTKYCQLHILKDSKQKLYTGCTNVIKRAPAGPLLCGKPTLASTVPALCNIHFQKAQKHVAKALKDAGHNVSSTSKPPPKLHVIVAAFVHHIQAKRKNPQKECKLKSVVKEENTS
The following text describes a protein:
Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MASISTWFRYMAHKLEYSLTLSLKSHRSNKLSDRELIQIICKNLFYGKITYLHSDKGPEMSPTMTANENTLLIRKIPIANTRFVFIGDAVVLKDPNDSDKYLVRRLAAVEGFEMVSGDEKEEPFVLEKNQCWVTAENQELKAKEAYDSRTFGPVSTADIVGRAIYCLRTAVDHGPVRNSQTAMGQDSPILAVELDVDEMAKNHKA
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSINEEDYLQLEKEIKLDDIDFSDLEEKYEVNIGLDNYIIVDGAPIAPEAKVPVLIKVLRKLFSQVGEIVEGDEGIYMPLENGKSKGYLFIQFKSTESADLAIKKLHGKKLDQNHRLLVNKLSDMEKYGVDGAVNEEFIEPEIEPFQSHGYLKSWLQDEQGRDQMVLHFSETVGVYWNKKSADPEPVIEPRKGFTSKYAKFSPKGTYLFSIHPQGIQSWGGANFNSIKRFFHQQVRLVDFSPNEKFMVTLSPIPISLPDSTVDRAQFPFGPESEGHKLVIWNMITGEPVRTFALPPHLEGQKEMPWPLVKWSYDDKYCARQGPDALAIYETESNFQLLDKKLVKVDGIQDFEWAPAGVKLHNSKAVDGKHVLSYWTPESTNQTARVALMQIPSREILRTVNLFQVSDCKMHWQSNGKLLCVKVDRHTKSGKTIFSNLEFFKTNERDIPVEKLELKDVVVNFAWEPNTERFITISRLDDGNPNPAIPKNTISFYAPEVTKGGVNHNSKKKGGAAIAAAVAAAAINNQSSTKYKAYTKIENKHSNTIFWSPKGRYVVVATISRTSGELEFFDVSFDDETNKKSLPANVKLLKTDKFSGMTNISWDPSGRFVAAWSTSWLHAIENGYRLYEFTGNLLRDDSIDQFKDFVWRPRPPSLLTNSDKKKVRSNLREYSAQFEEADAMEADAAVKEIILARRKALEEWRKYRAKHISKQGNSKNEVQAEIIEEIKEEIIEEKEEIVE
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLSIVGLQGPDWVLIAADSSVSSSIICMSENYDRIAQLDDRHALAMSGETGDCLQLSEYLQGNVALYKFRNGVELSSDALAHFIRHTMAKAVRKSPYEVNMLLSGYDGKPHLYFMDYLGTLQSIPYGAQGYCQYFVMSVFDKHYKEGLTLEDGKELMKLALNQIKQRFTVAPHGFIVKLVDKNGITKIDLE
The following text describes a protein:
Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MFIDLNVVWPTLGVKDLNLVKTVKTLERLGYTAIALNYQYDGKLQNVIKNPIVKELYPEQKIKIYSRITLTIESMPQNKVLSNVTKEFDILAIRPIGDRLLQQTCSDLEFDILSIDFTQRLPFYLKHTFMGLAVSRDIGIEISYSSGLRDVSNRRNLITNATSLVRATRGRGIIVTSETRTPLECRAGFDVINLATFWDLKQDQARKSVGESCRSVLLHAETRRDTYRSILNGCH
The following text describes a protein:
Function:
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac).
Subcellular Localization:
Nucleus. Note=Detected on chromatin.
Domain:
Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions. Bromo domain 1 mediates binding with histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively). The bromo domains also recognize and bind a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac).
Sequence:
MSMSSRHLHSSIVNPPPPEYINRKKTGRLTNQLQYLEKVVLKALWRHHFSWPFQQPVDAAKLNLPDYYQIIKNPMDLSTIRKRLEYNYYSKALDCIQDFNTMFTNCYIYNKPGDDIVVMSQELEKVFMEKIAEMPHEEIELSVVGNRGVKSRIKISAVAAEVCKKKMVSQKMHRRTFPCPVIAMMPKRTTLVPLSVIRSSTSSHSASSVSKVNKGIKRKADTTTPAVSLIATSCESSPTLSEPKPNKILSGTEKTRSAETSAVDLPDSQHHIHFIKSNQICEQLKHCNNILNEMMSKKHAEYAWPFYKTVIPTSLLDCSDAIKHPMDLATIRDKMENGLYKDTQDFASDVRLMFMNSYKYNPPDNEVVNMARKMQDVFEGMFAKIPDDPLATQSMVERYKTSTEESSSSSSSEQSSSSDSEDERAQHLALLQEQLRAVQEQLKALTETPIFSKIQPKSAVGVYDKYKQWVKCIEPMGKLLKRKKNYDAKKKKLHVSDEEEDVKPMSYDEKRQLSLDINKLPGEKLGRIVHIIQSREPSLKDSNPNEIEIDFETLKQSTLRHLEKYVMVCLRKRPKKPSSIKSLKSKEQLNKEKKQELEKRLRDVSGQLSSAKKPKIQGFLYPMQSIGGPSRLSESSTSSSASDVSNSSDSSSSDSSDSESATFPKNILAKKQTSTNYEVPLLLYYGCFVNKPRTSIPQNGLCIGSQSLAYTTISTIVHPTPMALMPLHPGSTNYTSLQLLLKYGLHVPLIIENPLGNSVLFENYLEVLHPSQIEQTFAIKEECLKPKYKNAKVKTSFCWEVFSKSLATTHVTIKSSSNSFQQFRKAAIAKEERERALKAQELRRLEDSKAGMQEKLSPSLPMETKVHEMQAQTIDEATKGEPTCNPVHEGITEEERNLARMREQERRRREAMAGTIDMYLQSDIMATFEEHLC
The following text describes a protein:
Function:
Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPKVTDIANELKQAIDAKDEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKALKGGSEESLLMDLFSDRHEVRAQHIRDALSGRNDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVEDFMKDVGRKEDWCLLMEKWMAHERVSRPGSPEDEAQRLDQAFDQKNTAYLIDFFGTVPSAEYRPIAEAFKAQNGKSIEQAIATIYTKTDYYTFYCAHFALLGMHRLAAYLINCACNDKGDEKRMRRITGMMVDKCLGAKHAYKIYGDMGTDIERCFDKRMAPILRTLWRVK
The following text describes a protein:
Function:
Acts as a negative regulator of nuclear pre-mRNA 3'-end processing (mRNA polyadenylation) (Probable). Plays a role in tissue-specific expression of protein isoforms by regulating differential processing of pre-mRNA 3'-end (alternative polyadenylation). In neurons, regulates alternative polyadenylation of specific mRNAs including unc-44 and dlk-1 by interacting with phosphatase ssup-72 and thus preventing ssup-72 dephosphorylation of RNA polymerase II subunit ama-1. Specifically, alters the usage of internal polyadenylation sites (PAS) to promote the production of neuron-specific unc-44 isoform and dlk-1 isoform c, both required for normal synapse and axon development. Conversely, in the epidermis, by inhibiting ssup-72 function, promotes the usage of an internal PAS preventing the production of one of unc-44 isoforms. In neurons, also negatively regulates protein levels of pre-RNA processing protein psf-2.
Subcellular Localization:
Nucleus. Nucleus speckle. Note=Also localizes to a small subnuclear ring in neurons. In neurons, partially co-localizes with pfs-2 in the nucleus.
Sequence:
MGEPSPSRRRSITSGIPCPSPTKQVLPPPPPEELHNILRKRPRSSAIPTTSQTHVRAPRKETDVVDRIWHDIDEEQREKLARRKEEAAKRKEQQPAQHIRDYLPLTATNLRNFRNEDSTISDFIHRQGMVDKLLGYKMLLGKMENCGTLGYEKMSEDEVQQLSREWLKNFFPSEQAHVGPRTPPSPAVDSDGGSYPKRPRRGPKTPPGSPGPSMDQAAVNRRELIEQLARNFGISSYKVEETLGTGLDKALEDCSKKLKNELMETFKDQLLSQIDRKTKIRDDLSDQMELVSDCSLSPDLIKKEEPDVVYHMAVPPPPIPPPIQPPPYSYYPVAPAAAPQVYHYAPPPPPPPPHPQQGLYQQNMMAYPPPMQHFNAPPPPMAPYQHQAPPSIVLPPVNVPPPPIGVRIDTPIPTAVLPIPTMVPPPPLPPPQAPFSGDCWRAQPAAPVPASVPVSSAPPPSVVVNVQSTLFSALGLHHKPPPPPPPPPPPTTSSTTTSHIPPPPPPPLPFSSAPPPPPPLPMVAAGPSPPSFVPPPPPPNPNQNPSIVLSPSAVTGGGGYRHRVNQFPPQQQQSFSNF
The following text describes a protein:
Function:
Involved in DNA excision repair.
Subcellular Localization:
Nucleus.
Sequence:
MASHIRGNLTEEQLKRIEANRKRALERLQQKKKKDAGEHVPSSTPKSTSTTTTKETGSYSPTKTLSQIVNSDSVQVSSKFVEIETDGSVKKRRVLTEEQRQKIEQNRLRAIEIQKNLKQRENQKDDSTTSSKPVDNIRLNQNRPDSVVSSTKKFQPPPIRKQDYIEFDFATMKDTKGGFLQDEKTNTQGADEQTLQDWKNKQRELQKIRELPPPIDLQNIPRCRECQSMEVDANLMTNFNVRACRKCIKALPEKYSLLTKTECKEDYLLTEPELQDTTLLPRIEKPNPHGYSRMQLFVRFQVEEFAWKKWGGPEELDKEWERREENKVKRKEKKYHDQLREMRKRTRAEEYTRKLRDGKSLGERHVHDWSSPVNIDKHTIKRRCIDCGIETEEVVI
The following text describes a protein:
Function:
Repressor of the lactose operon. Binds allolactose as an inducer.
Miscellaneous:
MISCELLANEOUS: Removing residues 1-59 results in loss of DNA-binding activity but retains tetrameric structure and inducer-binding activity. Deleting residues 340-360 results in loss of tetramer formation, but retains dimer formation, inducer-binding activity, and DNA-binding activity (if residues 1-59 are present).
Sequence:
MKPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKAAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTTLAPNTQTASPRALADSLMQLARQVSRLESGQ
The following text describes a protein:
Function:
Transcription coregulator that can have both coactivator and corepressor functions.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Sequence:
MPVKRSLKLDVLLQENSPQACRSRGQLVASYSPTTGTREISPSSSPQTHGGWELGRCPWHDRMELGPSPGFPRRGQPRVENQDDIMMLLYKIDKSLEKFTETWQSLKHLKALMGRPELENLIGVSQTSLDLKSEVQKARELMIKVRKQEQPRQKTREHSTGDFGHLNSYEFLKSIMT
The following text describes a protein:
Function:
A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Sequence:
MLVRGLPLRSVLVKGCQPLLSAPREGPGHPRVPTGEGAGMSSHSPRPFKEIPSPGDNGWINLYHFWREKGPKKLHYHHFQNFQKYGPIYREKLGNVESVYIVDPEDVALLFKFEGPHPERFLIPPWTAYHQYFQKPVGVLFKSSDAWKKDRLALNPEVMALESIKNFIPLLDPVSQDFVSLLHRRMEQQGSGKFSGPIIEDLFRFAFESITNVIFGERQGMLDEIVDPEAQRFIDAVYKMFHTSVPMLSLPPDLFRLFRTKTWRDHVAAWDTVFSKAEQYTEKFYQDLKQKRHFDSYPGIFYRLLASNKLPFKDIQANVTEMLAGGVDTTSMSLQWHLYEIARNLRVQEMLREEVLAARRQAQGDTSTMVQMVPLLKASIKETLRLHPIAVTLQRYPQNDLVIRDYMIPAKTLVQVSIYTMGQDPTFFSNPRRFDPTRWLDKNKDLTHFRNLGFGWGVRQCLGRRIAELEMTLFLIHILENFRVEIQHLNDVDSTFGLILIPEKPISFTFWPITRAPPQA
The following text describes a protein:
Function:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.
Subcellular Localization:
Chromosome. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages.
Sequence:
MDVQKWYLRTSKLALALAIIRSKPADKSSREYTEHLAMLLSEEQSKWRSKVEILEAEVMQLRQKLLVSRLCSGSFKSGYVSSQLEAQEPKSSESTLTSMEDSGCDLSNEQRTESSDLSQHFVESCTPTHFPPLPLVKRPCAILQNPLSSHMQFLQYLLELKNLTESGNLKRDLTHFEKDSSTVSDSVFQLLDGLITFYRNPKLPFSRFWTEAVGTLASLISDYNLSSHILKKCSKKLEEFEKTLLHAILGNNHINQFQVQHYVSQSLVTLGNCSLLRKSIISLLLSEVNGFADDLGAINQEQASYDVSRYENIFYLFWVLEQLLQKETEEGNTSSIGHDDQEIKKFLQKHDETIFQLSDAFPLFTFYLWRVGILLSSAQIETLRK
The following text describes a protein:
Function:
Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (By similarity). Transcription repressor that regulates organ growth. Binds to the promoters of G2/M-specific genes and to E2F target genes to prevent their expression in post-mitotic cells and to restrict the time window of their expression in proliferating cells.
Subcellular Localization:
Nucleus.
Sequence:
MSSSSNPPVCSPEKEERSEMKIEIQCMENKQPLAASCSSASEGSGCFFLKSPEIATPATVSSFPRRTSGPMRRAKGGWTPEEDETLRRAVEKYKGKRWKKIAEFFPERTEVQCLHRWQKVLNPELVKGPWTQEEDDKIVELVKKYGPAKWSVIAKSLPGRIGKQCRERWHNHLNPGIRKDAWTVEEESALMNSHRMYGNKWAEIAKVLPGRTDNAIKNHWNSSLKKKLEFYLATGNLPPPASKFIVLKDIADGDRDSKQSSATKPFKDSDSLTQTSSGNTDSNEVGRDHFDSSSALLEEVAASRRIGVNEYACSPVEYKPQLPNLEPISEEVRINSKAYFERSIQRKVENGFGTPKHGNLYYKSPLDYYFPSEADLQHMYGYECGCSPGAASPVSLMTTPCNKDSGLTATRSPESFLREAARTFPNTPSIFRKRRKVVLAAKTDAVVVVNGVVKEVDRKEESKDMRKSLLLETTDNCSDDEELGLNGNAFNLSPPYRLRAKRTAVIKSRQLEFTSEKEKQPDNEIEFTSAKEKQPDNEIKTSEEDKPV
The following text describes a protein:
Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
TSLRFYPSSRQSLQRKCFHNINNLIFFTQGFRELWEAGCLCDIRLVAEDETFPAHRSVLAAASCYFRVMFTTDMKERNMDSVELKGISAGGLKCALDFIYTSQLVSDLESLEDALITSTHLQIPHMTACCAELLQSSLTADNFLEILSLSSRYDLASLKGECLAFISQNLDVILKTGESSLLQMDADGIWGLLRRDDVSPRVSETALLELVLKWVEYDLDRRQPYTELLLQEVRLGLIFPPGCGFEGDLGAAAELVKALPKGQAYLDMLSEQCLGLQTDSPVRNWFRIRSTRKAVLATCGKTTGSRECSDRGQTSQTWRTIAHVEGMYNHCAVVLNDYLYIIGGQNSWFNTNHEEEATACVRRYDPRFDKWTRLADMHVRRRRFHCSALGDRIYAVGGRGEGGILSSSECYSPAEDKWTHIRALPCPLSSHAGAAYSNRLYVCGGSSGEIFSNAMYQYSPELDEWTPLPPLRYARGFHSMSPAGDKIYVMAGQARSYSDVLVTECYCPASRQWTELSPLPVGHSQHGAAALGSSIYIMGGFSWTEEGFLSSVHVYDREADAWRAGPQLPRPLVGVASGTLTLPHALRGKGDTTEPEPEPS
The following text describes a protein:
Function:
Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Cannot use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2-phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo.
Miscellaneous:
MISCELLANEOUS: Binds GTP first, before binding AdoCbi-P.
Sequence:
MDALIMAGGKGTRMGGVEKPLIKLCGRCLIDYVVSPLLKSKVNNIFIATSPNTPKTKEYINSAYKDYKNIVVIDTSGKGYIEDLNECIGYFSEPFLVVSSDLINLKSKIINSIVDYFYCIKAKTPDVEALAVMIPKEKYPNPSIDFNGLVPAGINVVSPKHGYQKEEIMVIDELIFNINTKDDLKLAEMLLKKDGL
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MEVHGKQQASGTKVVLAAMGGLAIGGSLVFLMGFSFLASLTLLVLSSPLLLIFSPLLFFAGFVFVGAVVGFAVAGAMALTGMSTLGWIFQELGGTSLLGFGGGLAERLKEQGKDWAGFLQHGNEQGIKIARRGQNLLVV
The following text describes a protein:
Function:
Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation.
Subcellular Localization:
Nucleus.
Sequence:
MGTSCNKINSNSNKGKENMHFVLDDNGDSKGNASNQQVERDDKLDMETTRWNGKEFEEPLSTNKKLIIQSNNTSSQHSTPPLSISDTSTHTGSSTDNVEANPNTGFSSARKRSLRSSNLKKKFVPLSSPEESNESEFIDDDESDEVASIIDIKEDETFDSKVEIPEAAPSSSTESDEESIPLSYQSKRRRVSARASSSASSSSRTQAKSIPSHERTHYRLIRQHPELEHVWEKLEEEAPREVKQIEQPKELVLNLLPFQREGVYWLKRQEDSSFGGGILADEMGMGKTIQTIALLLSEPRGKPTLVVAPVVAIMQWKEEIDTHTNKALSTYLYYGQARDISGEELSSYDVVLTSYNVIESVYRKERSGFRRKNGVVKEKSLLHQMEFYRIILDEAHGIKSRTCNTARAVCGLRTTRKICLSGTPLQNRIGELFSLLRFLRADPFAYYYCLQCECKSLHWRFSDRSNCDECGHKPMSHTCYFNAEMLKPIQKFGYEGPGKLAFKKVHSLLKHIMLRRTKLERADDLGLPPRVVEVRKDLFNEEEEDVYQSLYMDSKRKFNTYLAEGVVLNNYANIFQLITRMRQMADHPDLVLASKRKTVDIENQENIVCKICDEVAQDAIESRCHHTFCRLCVTEYINAAGDGENVNCPSCFIPLSIDLSAPALEDFSEEKFKNASILNRIDMNSWRSSTKIEALVEELYLLRKKDRTLKSIVFSQFTSMLDLIHWRLRKAGFNCVKLDGGMTPKARAATIEAFSNDINITIFLVSLKAGGVALNLTEASQVFMMDPWWNGAVQWQAMDRIHRIGQKRPIKVITLCIENSIESKIIELQEKKAQMIHATIDQDEKALNQLSVEDMQFLFSN
The following text describes a protein:
Function:
Transcription repressor.
Subcellular Localization:
Nucleus.
Sequence:
MSELENLKDQIKRIDEMIVQETNEETRVEYEQTKMDLEELVSLMEEDEEKTQKSPDDDEIDEQDEDSAEIDDTSTDSLLGSRCMVPYDSDRSLSLHTAIIMEIESSKRVRVLFSHPTCSAMKPCTHFLSSSCKFNENCRFSHGYSVELERIQDYQVPDYSFIVEEGLVLVKGMSDIWELGRISAIDTQNVAVKVLKSGIEISSKRKDLVPIGEVEEPTKQEQSSESWKELKQETLGNVTVGDLGKWNGGGVGMKLMMKMGYKVGEGLGKRSDGIVHAIQARICKKNASLDEVMTRKRKFIDRKEVQKNKNIKKLKTTDESEMDIFAFINRKLEKKNERTFADVRKETQEMAGYSSKTLGAKNLDLELELKQLKEKQNKLKSGIQRNRGDKNTVSKMSESLREVDAKIESINRKLNRIQSEVSSRNSKRKNEF
The following text describes a protein:
Function:
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine polymers in chitin to form chitosan and acetate. May play a role in evasion of the host immune response; plant chitinases liberate chitin molecules from the fungal cell wall which act as elicitors of the plant immune response, deacetylation of the liberated chitin neutralizes elicitor activity.
Subcellular Localization:
Secreted.
Sequence:
MHFSTLFGAAATAALAGSTNASPLARRQVPVGTPILQCTQPGLVALTYDDGPFTFTPQLLDILKQNDVRATFFVNGNNWANIEAGSNPDTIRRMRADGHLVGSHTYAHPDLNTLSSADRISQMRHVEEATRRIDGFAPKYMRAPYLSCDAGCQGDLGGLGYHIIDTNLDTKDYENNKPETTHLSAEKFNNELSADVGANSYIVLSHDVHEQTVVSLTQKLIDTLKSKGYRAVTVGECLGDAPENWYKA
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
Subcellular Localization:
Cell outer membrane.
Sequence:
MVARGGGRPHRLFGLVVPGGRLVTAVHRGPVSRLTRRTVMRANGRGLSVRRLLLAVIAAVSLGGLIDIATVAPASAQFTYNPLPPRPKPPKAANDNQMLVQATEVDYDYNNSRVSAVGNVQLFYNGTSVEADKVIYDQKTKRLHAEGNIRMTDADGKITYAEIMDLSDDYRDGFVDSLRVDTADQTRMAATRADRSSGNYTVFDNGVYTACAPCKDDPKKPPLWQVKGARIIHDQQEKMLYFETAQLEFFGVPIAYMPYFSTPDPTVKRKSGFLMPGYFPGTTNTGFGAEVPYYWAIAPDMDATFTPRFMSRQGALLQGEFRQRLIDGAYQIRAYGIYQLDPGAFAGQPGDRQFRGAIDTKGQFALNDKWVWGWDGVLMSDYYFFSDYRLAAYRDPLGSFLNLPTDAISQLYLTGVGNRSFFDARTMYWLSFSGNQNQVPIVYPVIDYSNVLNYPVFGGEFSYKTNFVNLSRDTAVFDPITTLANTNSLCTTASADPLARTPSQCLLRGFPGTYTRLTAEAQWRKSFTDPLGQIWTPFASLRADAINSSVSNQPGVSNYLPVGDTQAIRLMPTVGLEYRYPFINVQPWGSTTIEPIAQIIIRPNETYAGKLPNEDAQSMVFDTSNLFSVDKFSGYDRVEGGGRANVGVQATTQFDRGGAVKTLFGQSYQLFGMNSYAVQDSINTGVDSGLDKPRSDYVASIAYSPNRTYTFSVRSRMDEQTWNVQRFEAEGRANFDRWSISVMYGNYAAQPELGYLTRREGILTSGSLKVATNWVVSGSARWDLEANKINQYVLGAGYVDDCFVLAANYVTSYSYSAGTTPPVLSHAYMFTFGLRTLATSSTTSSTGGLQ
The following text describes a protein:
Function:
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Subcellular Localization:
Cytoplasm, P-body. Nucleus. Note=Shuttles between nucleus and cytoplasm.
Domain:
Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex; The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.
Sequence:
MFFDQSGLAVAAPPPDVPELMGIESEYVQTQCILADGGDRFGVSALAFDRYEELLWMGNQGGHVTSYYTGAMQKYTSFQIHATEDVRQVLTINEGVLGLTSSSLRYQIRRGIPVFTHTSANMYEMQCMLQVGATRLLMGGHHGKLIDFNIDLCKEMQVVDVGEPGCVMLRPHSRFVCAGNPLGRIDLRDPNTLNTEHTLETHSGSLSDFDVQGNLLVTCGFSNRHGNLTVDRFLMVYDLRMMRAVTPIQTVLDPLYLRFLPSVSSRLAVVSALGHAQILDTVAFAEPRLCLMQMDSPAMCLTFDISATSQALAFGDSTGSIHLFSSTAQPLFNSYSRMTEHGDPLVTYPSFAIDDFETPLAVIPMPICHDGLSSDWPEHLMKKCYRRPVGVDPEVLRTMKMKGPIGYAPNPRTTRRNQVMYEIDNNKARALNKHDRNAKLDDSEGFIAIPKRYRKIDVKYNKLGTDECQFDQFNKTGHTGLEATLPNAYCNAMIQVLYYIEPIRAVLLSHLCNKEFCLSCELGFLFHMLRTSSNNSPCQPANFLRAFRTIPEASALSLVYSDLPPDQKTKINLGALIQSWNRFIIHQLHVELAEAKKKNTERKNNKTPFSYNVTDFPAIDDRKKCSASEVNANMEQEKRDSESEIIQLLGAKQIQKHSCLKCKLEVKKESILLVCNLIYPTNEPERDEWSFCDILTRSLCSQQTTPAWCEECKKFAPTQQTRVLQSLPKLLAINTGLHNPQHKQFWQSQMDKVVAKVTENAAPPTAPQINSLSSSKPCRYGDHCSRPGCRFRHSFDNVPPPAPVNNPYCSNNWLPHSISIALKEGELIIEKVEDKKEVEGEERVEDELYDLTAVVCYINDPASSEKRNIVALIKVPDSYLSETTQSEHKWYLFNDFSISTVSMQEAVWFSLDWKIPCILYYSSRGILKAKSEISPPISKEVFTEDACIARSWGTSAITFTPLTDNEFPKKGDLVAMDAEFVTLNQEEAELRSDGKMSMIKPSQMSVARITCIRGSGPMEGVPFIDDYISTQEQVVDYLTKFSGIKPGDLDANFSSKHLTTLKSTYTKLRFLLDSGVIFVGHGLKNDFRVINLVVPPEQVADTVHLFHLPHHRMVSLRFLAWHFLGVKIQSETHDSVEDARAALHLYKKYKQLDAQSKVGEALAELYERGKLLNWKVPED