lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
Sequence:
MELDEVIITRAIFDEYSKTFLDYTDIDVALVGGGPANLVAAKYLAEAGVKVALYEQKLSLGGGMWAGGMMFPRIVVQEEATRILDDFGIRYKEYESGYYVANSVESVGKLIAGATSAGAEVFNLVSFEDIMIRENDRVTGIVINWGPVTTQRLHVDPLMIRTKLVIDGTGHEAVVCNTILRKIPNAKIGELGLLGEKPMWSEVGERLAVNATQEIYPGLIVAGMAANAATRAPRMGPVFGGMLLSGEKAAKLALDRLKTI
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MGDVRLSALSTLNYRNLAPGTLNFPEGVTGIYGENGAGKTNLLEAAYLALTGQTDAPRIEQLIQAGETEAYVRADLQQGGSLSIQEVGLGRGRRQLKVDGVRARTGDLPRGGAVWIRPEDSELVFGPPSGRRAYLDSLLSRLSARYGEQLSRYERTVSQRNAALRGGEEWAMHVWDDVLLKLGTEIMLFRRRALTRLDELAREANAQLGSRKTLALTLTESTSPETYAADLRGRRAEELARGSTVTGPHRDDLLLTLGDFPASDYASRGEGRTVALALRRAELELLREKFGEDPVLLLDDFTAELDPHRRQYLLDLAASVPQAIVTGTELAPGAALTLRAQAGRFTPVADEEMQAEGTA
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Is involved in resistance to the arginine analog canavanine (CAN).
Sequence:
MGKRVKKNRRVPPKEKKVVAAQSPKAIPQEKTAGIDDVDDEVKAVKERKKCLHFDKGINIDKLLTKLRSSDPIRCEDCREGRNDRRGGKGKSKHGKKKGSASVESKSESKAIWVCLECGHYVCAGVGLPTASTSHAVRHLRQTRHHLVVQWDNPQLRWCFSCNIFIPVEKMEENSESKDVLYEIVKLIKERSSESSTNDVEDVLSGSGSVICDIKSEGTISNFLDGKNGYVVRGLVNLGNTCFFNSVMQNLLALNRLRDYFSNLDVSMGQLTISMKKLFAEIRPEMGLKNAINPKPFFASLCSKAPQFRGYQQHDSHELLRCLLDGLYTEELALKKHINASKSDAVTASQDLTFVDAVFGGQISSTLCCEECGHSSTVYEPFLDLSLSVPTKKTPSKKAQPVFRAKKTKLPPKKVGRNRGKVNKDVDQAPAKVVTAPVPNSESSGPGHIAVPQMEPKVASSGDSSRSHAAGPSTDESSSASRNLFDVVESQKEQVVESTVKENSAGTDDFAWLDYLTTENTLPENDTGADDFSWMDYLQQEIVADESDLISQNKNTSLQDSEEKELVPNEALAESCEVSVLKGETNKKTEDSSGNLQEEELPLLVQDSVVLLLPYKEDIPGTLSVRENEASSSNAGLGQEEVEFDGFGDMFNEPEIAEGPIIGPSLANEVAETGFMAGSISDSDPDEVDDSNSPVSVESCLSHFIKPELLSDDNAWNCENCAKILRHQKLKAKKKQTKMGKDLLNGSETRSLDMEHQCPNGVRTISNGDISSSSDSSVFHNKNQNGVKVENGQTSELDSVELEDASPLKSNSSVSSKCYAQEKCGGTRTIDSCNVENPSGNETFRQSNSHMTENCQSGVIDDEELDSENLKVKRNATKRVLINKAPPVLTIHLKRFCQDARGRLSKLNGHVNFRETIDLRPYLDPRCEDADNCNYSLVGVVEHSGTMRGGHYIAYVRGGEKRKGTTGIDHVGSQWYYVSDQHVRQASIEEVLRCEAYILFYEKV
The following text describes a protein:
Function:
Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.
Subcellular Localization:
Secreted.
Sequence:
MKLSTALVLGATATGAWSYAIPQLEQEVLELPETHYEQQEKYLIELSPYQTRWVTEEEKWALKLDGVNFIDITEDRNYGLFPTLDAGSYVNYPQKMGYVDTVKGLIAGLSMDNMRKDLENFTSFHTRYYKSSSGVESAQWLYDQVSKVVRDSGADKFGATVQKFDHSWGQFSIIARIPGLSKKTVVLGAHQDSINLFLPSFLGAPGADDDGSGTVTILEALRGLLKSDIVAHGQSPNTIEFHWYSAEEGGMLGSQAIFSKYKKNQADVKAMLQQDMTGYVQGTKHAGQKESIGVMTDFVDPALTSFLKNTIVTYCAIPFVETKCGYACSDHTSASKYGYPSAMATESTMENSNKHIHTTDDKISYLSFDHMLEHAKLTLGFAYELAFAAL
The following text describes a protein:
Function:
In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSVVGFDFGNERGVVAVARQRGIDVVLNDESKRETPAIVCFGEKQRFLGTAGAASSMMNPKNTISQIKRLIGRQFSDPELQRDIKTLPFLVTEGPDGYPLIHARYLGEVRTFTPTQVLGMVFSDLKTIAEKNLNAVVVDCCIGIPIYFTDLQRRAVMDAATIAGLHPLHLIHETTATALAYGIYKTDLPENDPVNVAFVDVGHASLQVCIAGFKKGELKILAHSFDRNLGGRDFDEAIFQHFAAKFKEEYKIDVYQNARACIRLRAACEKLKKVLSANPEAPLNIECLMDEKDVRGFLKRDEFEQISIPILERVKKPLEKALAEAGLTTENIHAVEVIGSSSRVPAIMRILTEFFGKEPRRTMNASECVAKGAALQCAILSPTFKVREFKVNESFPFPIALSWKGPAPDAQNGALENHQSTIVFPKGNPIPSVKALTFYRSGTFTIDVQYADVSELQAPAKISTYTIGPFQSTKGERAKLKVKVRLNLHGIVSVESATLLEEEEVEVPVVKETAKEPAKMETDEASVDAAPSTTSESDVNMQDAKGAAAASGAENGVPESGDKPVQMETDAKVEAPKKKVKKTSVPVTEIVYGAMAAADVQKAVEKEFEMALQDRVMEETKDKKNAVESYVYDMRNKLSDKYQEFVTDSEREQFMAVLQEVEDWLYEDGEDETKGVYIAKLEELKKQGDPIEQRYKEYTERGPVIDQFIYCINSYREAAVSTDPKFDHIDLADKQKVLNECVEAEAWFREKKQQQDALPKYANPVLLSADVRKKAEALDRVCRPIMTKPKPATPETPPPQSPQGGEQQPPSAESPNAGNATEGASAGSEVPPAAEPMETDKSETAPSAS
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MNLLKNLECLAPGSPNVSDQSSKANSIANENLNDLRKDVNNKTVKTDQITIFYAGSVHVFDGLPVDKMKEVMNYAAKFSPCHISGHFVSNGGGSSETGHEKLMASTQNSSIGAGRSTYQELLQAKTEAAASDLPIARRASLNRFLSKRKDRALVRAPYVRNSPTAASTHEEGSSIH
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSRVTTELDFFGLEKKQTNNVPKPKFKKFLDRRRSFRDIQGAISKIHPEIIKSLLASGANHADSSTISPSVPSTPKADYPQIPISPVQAPLTMQTEHSSGTVPMTIFYNGTVSVYQVSPNQADDILKVVMETAPKKDKSIVKDHLVIPPTTLRTKLFGKNLEGDLPIQRTRSLQRFLEKRKERLVSISPYFPTSG
The following text describes a protein:
Function:
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Subcellular Localization:
Secreted.
Sequence:
MLTFPRGDRLCYLSHTISSPKDQRGHSMLSSLKTLLLLSVLCAPTSSLCLRFYPTRSRLLCNDYMAIGVGSDKSEPDYSTTDGWGSLLQSAEYLTSSSSLSAESSREKRTSSPANYRFMSRTKLRGQMMRNNLNKGDRRSRLTLSLDVPTNIMNVLFDVAKAKNLRAKAAENARLLAHVGRRK
The following text describes a protein:
Function:
Transcription factor involved the regulation of plant development. Binds to the Up1 elements (5'-GGCCCAWW-3') in early light-induced proteins (ELIPs, e.g. ELIP1 and ELIP2) promoters to trigger their expression and promote chloroplast biogenesis; this activation is inhibited by OR binding in the absence of light to prevent cotyledon greening. Also supports OR expression. Together with TCP15, modulates plant stature by promoting cell division in young internodes. Represses cell proliferation in leaf and floral tissues. Together with TCP15, acts downstream of gibberellin (GA), and the stratification pathways that promote seed germination. Involved in the control of cell proliferation at the root apical meristem (RAM) by regulating the activity of CYCB1-1. Involved in the regulation of seed germination. May regulate the activation of embryonic growth potential during seed germination. Acts together with SPY to promote cytokinin responses that affect leaf shape and trichome development in flowers. Transcription factor involved in the regulation of endoreduplication. Represses endoreduplication by activating the gene expression of the key cell-cycle regulators RBR1 and CYCA2-3. Regulates the expression of the defense gene pathogenesis-related protein 2 (PR2) in antagonism to SRFR1, a negative regulator of effector-triggered immunity. Involved in positive regulation of plant defense. Represses jasmonate (JA) response to promote disease resistance. Regulates the plant immune system by transcriptionally repressing a subset of JA-responsive genes.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing TCP14 exhibit altered plant development and occasionally are lethal. Plants overexpressing TCP14 are modestly reduced in size and exhibit enhanced resistance to the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000, and the oomycete Hyaloperonospora arabidopsidis.
Subcellular Localization:
Nucleus. Note=Localizes in sub-nuclear foci.
Sequence:
MQKPTSSILNVIMDGGDSVGGGGGDDHHRHLHHHHRPTFPFQLLGKHDPDDNHQQQPSPSSSSSLFSLHQHQQLSQSQPQSQSQKSQPQTTQKELLQTQEESAVVAAKKPPLKRASTKDRHTKVDGRGRRIRMPALCAARVFQLTRELGHKSDGETIEWLLQQAEPSVIAATGTGTIPANFTSLNISLRSSGSSMSLPSHFRSAASTFSPNNIFSPAMLQQQQQQQRGGGVGFHHPHLQGRAPTSSLFPGIDNFTPTTSFLNFHNPTKQEGDQDSEELNSEKKRRIQTTSDLHQQQQQHQHDQIGGYTLQSSNSGSTATAAAAQQIPGNFWMVAAAAAAGGGGGNNNQTGGLMTASIGTGGGGGEPVWTFPSINTAAAALYRSGVSGVPSGAVSSGLHFMNFAAPMAFLTGQQQLATTSNHEINEDSNNNEGGRSDGGGDHHNTQRHHHHQQQHHHNILSGLNQYGRQVSGDSQASGSLGGGDEEDQQD
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MSTTKFNSISPIELLEIISSYDIQDEIKLSHIQNLKTHIKKDTIDLRNVPIYLQIITKGLEITRLNISSVSFNSLSYLIKRISVQDKSGNILKEECFLILPILINKLGNASSPAGTNSAKKSLEDYWLSSPIEVEDALTEIAFENPNTKITIETIDWMTQILKNISAKFNVPKFLPKILHSIEINPHNEEIIVSTKELLSIYLEKNPSAIEGFKKQIESHSLAQATKDKLLGSVISKLRGSDPEPHVQRANTPRSNTPVSQIQSSLVDVGHDVELLELLNKVNYEIDSSIKALDIRDANSLFNTFEIFMPCFDGKETESNWKVREKNILQMRSILRGNSATQFRSELVQCIHTIANGMCKGASSLRTTLSSNSCQLIKECAVILKKSLEPVAESLFPTLIKLCSSTKNIASTNANMSVAALYANLPYTSKMIQRITLASEDRNYQPRSYSLIWLHILLLKIGIDRSYIGHHDSSFIEAANKVFMKLLKDANPNVRQTAKECYWCFTRVFPEDAERLLKRLEPNIVRALERSQRESGGSGIAPIRTLSSRPSRPSLKEAILEKNKELRQRRPPSRNSGEQSTKIKSVPLPRPTKSSSRLEKSLLRPDVGHKSQPAVRASSWTYPSTQSGPKATFKQRERSKTEVHKKSPLEISRPSSRLDTGAVSSFNNKNDPMINFLSSSDSDLIKEGINLLKYAIIGKENLPSEINSLLKSISEKHVQFMKPLFTSNDYTFKKAASLLLPDDFLRVCALVFDEFDEAVISLIIQCIDVSTFYESACNLLTLVADTPNIPGSHALVMQISNQKLTITKSILQALSIALSKHAVTDVQFGEIFQELVKLIIVLKATDYYSLLCQLFRQLYTIDSNKFSLLVEDVEGKLKEEVEFIVGIESTMTLERPSSKLDYDLTVVKPTSNLGTFVLSQKPSADDFTMLLPKRSEFLGSGEVYNSKMVAKIEASDSSPQKQSQMDQISSKRSNSEHQSEVLVDDFANVSIADGGGSKLNQSKNDDDNLKQFMERIDPLKPISNKIRKISIYEDAKQNSEKPKLERNWGGFQYAKFSRAIRVNAVAENMSLTSQEFESCCSKLVETPSQSALLKMTWFVDSLSVSSYDYQEFFLNKGKHKLEKSLWEFFSKIDKSDHSLVMNGLFLLKQLLKFNDTPNVDKLFALLVDTCSQEELDSELYFIWNEMLLSLNHDELMKSFEKNALNYLEGEENNLTISSLCLNYLAKVLVDDNCLDVAKIYRLDTIFGKLFHEREVMFRKSATICYSNLLKNTNVSPEVKDTLDKVKSRYPASTQRLIEFYMKR
The following text describes a protein:
Function:
Catalyzes the transfer of a glucose moiety from UDP-glucose to another glucose that is N-linked to an asparagine within a peptide or protein. Can act in a repetitive manner, and this way it elongates the N-linked glucose by a glycan chain consisting of several alpha-1->6 linked glucose residues. Is able to add up to six glucose units in vitro. Cannot use UDP-Gal, UDP-GlcNAc or UDP-GalNAc as a substrate donor.
Subcellular Localization:
Cytoplasm.
Sequence:
MENNIDLNVYFCFVNRPCTGGDFVNLDHVRTLRKLGINASILLAGNQSEEIVNSFGSLPVVILNEEIEFSSQDIFIVPEVMQVLYDLASKMTVFPRMIMHNQNPFYTGYGFLSAQHINEHRLERIIVPSSYTKYKLQEIGVTKPIDIIHPYIPDYFKPAEKQREVIQIAFSRRKRSAEFDIFKFYFLSLYSHKHSVNFVNIQGLTREEVAKVMSEAAIFISFAERESLGLMTLEAMASGCHVIGFSGYTDIYNNEVIDDSVGDWIGEGEYTLFAQKVCQAIDDFVNGKMNPKIENGLRLIEQRFRIRHFEQEVKRVYGNIFDYDLENSRS
The following text describes a protein:
Function:
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of hymenopteran species.
Miscellaneous:
MISCELLANEOUS: Toxic segment of the protein is located in the N-terminus.
Sequence:
MATINELYPVPYNVLAHPIKEVDDPYSWSNLLKGIQEGWEEWGKTGQKKLFEDHLTIAWNLYKTGKLDYFALTKASISLIGFIPGAEAAVPFINMFVDFVWPKLFGANTEGKDQQLFNAIMDAVNKMVDNKFLSYNLSTLNKTIEGLQGNLGLFQNAIQVAICQGSTPERVNFDQNCTPCNPNQPCKDDLDRVASRFDTANSQFTQHLPEFKNPWSDENSTQEFKRTSVELTLPMYTTVATLHLLLYEGYIEFMTKWNFHNEQYLNNLKVELQQLIHSYSETVRTSFLQFLPTLNNRSKSSVNAYNRYVRNMTVNCLDIAATWPTFDTHNYHQGGKLDLTRIILSDTAGPIEEYTTGDKTSGPEHSNITPNNILDTPSPTYQHSFVSVDSIVYSRKELQQLDIATYSTNNSNNCHPYGLRLSYTDGSRYDYGDNQPDFTTSNNNYCHNSYTAPITLVNARHLYNAKGSLQNVESLVVSTVNGGSGSCICDAWINYLRPPQTSKNESRPDQKINVLYPITETVNKGTGGNLGVISAYVPMELVPENVIGDVNADTKLPLTQLKGFPFEKYGSEYNNRGISLVREWINGNNAVKLSNSQSVGIQITNQTKQKYEIRCRYASKGDNNVYFNVDLSENPFRNSISFGSTESSVVGVQGENGKYILKSITTVEIPAGSFYVHITNQGSSDLFLDRIEFVPKIQFQFCDNNNLHCDCNNPVDTDCTFCCVCTSLTDCDCNNPRGLDCTLCCQVENQLPSFVTLTDLQNITTQVNALVASSEHDTLATDVSDYEIEEVVLKVDALSGEVFGKEKKALRKLVNHTKRLSKARNLLIGGNFDNLDAWYRGRNVVNVSDHELFKSDHVLLPPPTLYSSYMFQKVEESKLKANTRYTVSGFIAHAEDLEIVVSRYGQEVKKVVQVPYGEAFPLTSRGAICCPPRSTSNGKPADPHFFSYSIDVGTLDVEANPGIELGLRIVERTGMARVSNLEIREDRPLKKNELRNVQRAARNWRTAYDQERAEVTALIQPVLNQINALYENEDWNGAIRSGVSYHDLEAIVLPTLPKLNHWFMSDMLGEQGSILAQFQEALDRAYTQLEESTILHNGHFTTDAANWTIEGDAHHAILEDGRRVLRLPDWSSSVSQTIEIENFDPDKEYQLVFHAQGEGTVSLQHGEEGEYVETHPHKSANFTTSHRQGVTFETNKVTVEITSEDGEFLVDHIALVEAPLPTDDQSSDGNTTSNTNSNTSMNNNQ
The following text describes a protein:
Function:
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
Sequence:
MVPSTFSRLNAARALPVVLAALLFAGCGTQAPDQSAAYMQGSAQADSAFYLHQMQQSADDSKTNWQLLAIHALLKEGKSQQAVDLFNQLPQNLNDTQRREQSLLAVEIKLAQKDVAGAQALLDKLKPADFAPNQQARYWQAQIVASQGRPSLTLLRALIAQEPLLAAKDKQKNIDATWQALSAMTPDQARTLVINADENVLQGWLDLQRVWFDNRNDPDMLKAGIADWQKRYPQNPGAKMLPTQLVNVQRFKPASTSKIALLLPLNGQAAVFGRTIQQGFEAAKNLGTQAVEMQPAAAPDAPVEPGVEETQPQMTNGVASPSQASVSDLTDDAPAQSATPVSAPQTPPATASAPADPSAELKIYDTSSQPLDQVLAQVQQDGASIVVGPLLKNNVEALMKSNTPLNVLALNQPETVRSFPNICYFALSPEDEARDAAHHIYDQGKQSPLLLIPRSALGDRVANAFTQEWQKLGGGIVLQQKFGSVAELKMGVNGGAGIALTGSPVAASVPAQPGVTIGGLTIPAPPTDAQITGGGRVDAVYILATPEEIGFIKPMIAMRNGTQSGATLYASSRSAQGTSGPDFRLEMEGLQYSEIPMLAGGNMPLMQQALSAVHNDYSLARMYAMGVDAWTLANHFSQMRQVQGFEINGNTGALTASPDCVINRKLSWLKYQQGEIVPAS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQRYWRFQDNKIQDICFGVLGESWIQRPVMARYYSEGQSLQQDDSFIEGVSDQVLVAVVVSLALTATLLYALLRNVQQNIHPENQELVRVLREQFQTEQDVPAPARQQFYTEMYCPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVNDYNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVITQRLTR
The following text describes a protein:
Function:
Regulatory component of the Usp12-46 deubiquitylase complex. This complex deubiquitylates the wg/wingless-signaling receptor arr/arrow, which stabilizes the receptor and increases its concentration at the cell surface; this enhances the sensitivity of cells to wg/wingless-signal stimulation. This increases the amplitude and spatial range of the signaling response to the wg/wingless morphogen gradient, facilitating the precise concentration-dependent regulation of its target genes. Required for wg/wingless-mediated signaling in the wing imaginal disc and for wg/wingless-dependent regulation of intestinal stem cell proliferation.
Sequence:
MANQLDASVKDDLKTQFVTREGTYRLLTLSEYSRPNRVGYSSNQSSPQVRVSMVTLPSPAQGKLGSDVGVGTPVGGGTAGANTTTTNGSSPGASPTGAAGASTAISNGGAGGDYSHSNHNSNSAGNNTVEARLGGGISMHSMMNGGVVDQNGVATNQVLGGDRICFNFGRDLYVYSFRGAKKGTEMSKPIDKKFYKGTNPSCHDFNISSATPTGAPLLVGFTTGQIQLVSPHVGPREVRKLFNEERLIDKTKVTCLKWLPNSPHLFLAAHASGHLYLYNEELPCAATAPSYQPFKLGDGYTILTSKSKTTRNPLFKWVFSTDNCCVNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERRVVARGQGHRSWVSVVAFDPYTTSYTNWDGGDFSDDENQMNEYSHSREARFSGDSTANGGFEGFDRNSTPVHADRNGPHSASFRSDASSAEKLMSYRLGSVSQDTQICLWDITEDVLRHPLVLRQPANSERAYLNGGVDEEAEAEDGIKVIRPVAMSGQATGQQAESGSCSPTREAAGGGTGNGAGEHSNSSSSKFSTANCTISSQSSPDDCDTEAATPASTSSNAGAGSVAGAGAVASTKQNNRNHGTGNSIKFPNCISATKSDSIDGGGGSGSGQRPSQTTSGYNSKTSNSSNKSSNSGSGFSAFNSLTQRLSNFSFLSSSEKKGAGYEGSHSTAHRQHRKAMSMLKSYNQHNHTGGHNNHSQSNNSSSSNFGHSSTLDSNAAGAIGSSSTAHSFGSLKLSRSSHHSSLATAAHASGSAAGSGSGVSSFDPMQLIGTPACPRFDECPLLEPLVCKKIAHERLTALIFREDCFLTACQDGFIYTWARPGHATHATQHLSPGQAAAPGGTVI
The following text describes a protein:
Function:
Prevents gene silencing by suppressing CHG methylation as well as histone H3 lysine 9 dimethylation (H3K9me2) status at target loci. Collaboratively with ASI1 and EDM2, the AAE complex regulates alternative RNA processing (e.g. alternative splicing) and epigenetic silencing (e.g. H3K9me2) of intronic heterochromatin-containing genes as well as genic heterochromatin-containing genes by promoting distal 3' polyadenylation, thus being required for the accumulation of their full-length transcripts. May also modulate transposable elements (TE) expression. Mediates RPP7-dependent race-specific disease resistance by promoting histone H3 lysine 9 dimethylation (H3K9me2) at the proximal RPP7 polyadenylation site, thus controlling alternative polyadenylation of RPP7 immune receptor transcripts and facilitating 2-phosphoserine RNAPII occupancy. In cv. Columbia, required for RPP7-dependent disease resistance against the Hyaloperonospora arabidopsidis isolate Hiks1.
Subcellular Localization:
[Isoform 1]: Nucleus; [Isoform 2]: Nucleus.
Sequence:
MATPEEVAYEKFLERVRRTVYVDELTPLATAPVISSAFNQFGTVKKVSFIPNYLGPKELPMGVLVEMENEEMTQAVISTVSQLPFMVAGMPRPVRACAAEPNMFVDKPKKPGRTVRFRWIKPNDPDFDKARRVKRLARKHSAENSFMLKKQLEEAEKLSKQQAETAVTHHKKFEMMDKLLYDGVAQKLAGRYDLKGFPYR
The following text describes a protein:
Function:
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
Subcellular Localization:
Nucleus.
Domain:
The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module; The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.
Sequence:
MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYNNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDSFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MDEDEKWMDCADSEWTKEKNLTAPVNKLEDKWKLVPAFLKVKGLVKQHIDSYNYFINCEIKKIVNANNKVTTDADTVFYLKYLNVYVGNPDIEESFNVTKPTYPHECRLRDLTYSAPIVVDIEYTRGAQRIRRQKLPIGRVPVMLRSSICVLNGKSPVELAKYNECPIDPGGYFIVKGVEKVILIQEQLSKNRMILEVDNKGNALSYIGSRVRQRKWGAKKLPVDEARDLLANVVLSHIPSILDDKDYYGNKRLELAGQLLALLFEDLFKKFNSELKSIAEKNIPKQRAGPVNMNLRFLEFDIVKYMRQDQITNGFNLALTTGNWSIKRYKMDRAGVTQVLSRLSYLSALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDSDDKIIINLLFNLGVEDINLLSGEELSLPHIYIVYVNGYVLGAARNYKKLIRTFRLLRRDIKTAQVKRILYLIANYINEFVSIYPNHTYRQINIALDGGRVCRPYIIVKSEKPLVTIKHIEELSQGIRSFDDFIRNGLIEYLDVNEENDCNIALYESDINSKTTHLDIEPFTILGVCAGLIPFPHHNQSPRNTYQCAMGKQAIGTIGYNQRNRIDTVLYQLVYPQVPLVKTKTIDLIEFDKLPAGQNAIIAVMSYSGYDIEDAVILNKASVDRGPQADAQTGKTIWKHKVLDADGICMPGEKVESKQILINKSIPSVTSTPIAGTGQKLLQPEYIDMPMTYRGPTDAYVENVMISSNNDEAFLIKTLLRSSRRPEIGDKFSSRHGQKGVCGLIVNQEDMPFTDQIMNPHGFPSRMTVGKLMEVIGGKASLLDGKFRYGTAFDGDKLEDLCQTLIDYNYSYAGKDYLTSGITGEGLSAYIFFGPVYYQRLKHMVLDKMHARAKGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIAYGTSMLLVERLMISSDAFEVDVCNNCGLLAYSKWCHYCHSSCHVSSLQIPYACKLLFQELQSMNIIPRLSLTQYIQ
The following text describes a protein:
Function:
Substrate adapter of E3 ligase complexes mediating ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, and which is involved in various processes, such as ribosome recycling and reticulophagy (also called ER-phagy).
Domain:
The shuffled ATG8-binding motifs mediate interaction with both ATG8 family protein and UFM1.
Sequence:
MPSQDDVQNLPIDITFSRLGEWLVDRKRIPADWRKRVAVIRVKILKEFSSLPKEIDPFFQTLDPEVIGYLEVKKVYEILLKTTPESRNIFGRLSGASGVWEAIVRAFEKDHIYLGEAAQIIIQNVNYEIPYLKKQVQKVQQQMTELDRKEADIKRSVALSATKYEDACRELGLQGNNVRRELLETASSLPSTFSKILEVINSDSVTGAMEYYSAYVQDVHTEKDKPLRIVLQNLKYIRENPPSLSVFGDSEGLDADNIQSSENANGTDAAADSIDWDITVETPEIDWDVSMVEEVDSGNDLGSYEIVNASDIPENSPFKVEESQGLEVDVSEISWDVSVETPQVEEIGDSALLESNQTQLTDSTTQVLGSGGERSQLLETEYRNKILDDLYEVKAFLNQRLIELRNEDTLSLQHHVQAVSPMVLQQYSPETIEPMVVDISMAISLLTNKKSRDLIMILNSKRFLDRLVSELEEKKHREVKLRESLKDVGRRRMELQNSLSAIWPKQEAALSKTRELKELCETSLSSMFDGRPVNIRGEINTLLNAGVSA
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MAATVPKKVTDAVAALHDVVSSIEGHLLELWDFRKELDGELQPLESARLNLALSESATILFCMYLKTRGVGDNANPVKKELERLQLYKTKVSKVADKQKGPKAPTVSLNVSAANRFIDHAIPDLSTEQRQRLQRKAADWKSKGEQQGPSKRQRPSAAESAKLFLEKAKAELEGKVLESRRIA
The following text describes a protein:
Function:
Serine/threonine-protein kinase that functions in the sphingolipid-mediated signaling pathway, regulating organization of the plasma membrane (By similarity). May phosphorylate PKC1 to activate the cell integrity MAPK cascade during cell wall and membrane stress. May regulate sphingolipid metabolism upstream of YPK1.
Domain:
The protein kinase domain contains a 228 residue insertion between the ATP binding site and the active site.
Sequence:
MASSHFGPASPASSTPPPSSAYARLIAPTITRNSSSSSSRSTTTCSSTSSVQAVPMRPPPIETSTAATSRSQLPSNRHSENEAEHDTSYTSPGLSVGGRGGLARNGPRSNRLGTSPQARHVPPSIVALSPSPSPILNMASKRQSNTETVSGTSPSTPLGKSFLAQQDLSPNSSTIPLRVTISVDPNDRLSHDRESHSAERPRSSGNSPVRGRHGHLSTPSSPTNSYRALGGKPRTLSVDAGQNWGGSHRSRARDGDDRERRQSQVSSASSGALKKHSLDDWVLGEELGVGSYSTVYCVTPSANTHSPTSPQPARKYALKVINQAHLIQEKKVKYAMVERDALIRLSDPRPSKGHKRGVSSSSSSGYAQTGSAGKRRSTASIGGQSSMASVSGGTVSNSKKDTRDRLSIVTTSSAASSPVLTASSGSTQLSPTAVSGGGGNIKGRRPSRSAEPPTPVQEQTEMLIRGGEDGKDGQDGQETPSREWDRDRDWDNMTRSRPPSPVREESAEGGEKEKDEEERSGAEPVELGAAIHLTLPPPQIPSTPEPRGSPLLSTDGHRTSRETPRDRPHLTPKRRRQSLAPSERSVKSASTTGKMSAAAHPGVVRLYSTFNDSSSLYFVLSLASNGELASIIRKHGSLDITSARYYAAQLIDTLEFVHSRGVIHRDLKPENILLDEDMRIKITDFGSAKIIAKDEPIVDDSSRSRSFVGSADFVSPEVLRNEVATTASDIWAFGCVLYQFICGKPPFRGATDYLTFQKILKREVEFPKGIDEDAKSLIDTILDLEPNLRPSITFIKTHPFFQSIDFSTLWTIPAPPISSGLREPSKSTTLAQLEASDIWGVFEGSDVGEEDEDGFEYDADTVSPRPEGGAVGEGMMEPLFDRRAAASAVHNVDHPKFSRLRNQYINLGEDLDPPRPAYAGAGTGGRGKREKEVEKKKGEKARGLSHGSESSGGNRSALAGWLEAIKFGGAGGGGMSGSATSVAASDTVRTPGTGTGTGPGSRPGSRAGIPSFGLGPGSGSRSNRGSGASMRSDEARDLSMSLGGLRMNMSKASEFDKWTPLLLANESIIFTSPITLRTSSPALQLHLPAFLLPAPKKRQLVLTDFPRLLMIKDDNEADGDPAGSDSGAGLSSSSHVESGGGGVGGGGRGGGHGSLRIKGEAVFVPRPSTATGSSTTKGGGYSAVPNAVMDVQEKGSKGFTVQTPGMVYYCHVDSVELRAKWMAAIHRVGL
The following text describes a protein:
Function:
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNDHESSDSSSDEFYEKIKAQLNIMDDEERSSRIVSRNEVLPKVAFVPPESKEQREFNFNYKNSDRIQLIGKIESLTKENIIIYSNLLEFVINLDQLIVNGQQEILGKVDDVFGKVERPHYSILLDGYVNNLVQTNQLKIGDDVFINIDSTSVLNPDAINKKGCDASNQFDEEVLNDCDVEYSDDEIEAVSKKRGNKEEGEVKKNHKKNKEKHPNQQKHDKQLPFPQQKFKAQGNNPQTQQQQQQMMQMQHSMQQQQYYQQMFLQQQMQLQMQQQQQYQQLISNQQAFPQQQMQQPQYMQQIYQQPQQLQPNPQLNLPYNTQQINQQLNQNLNSLFQNIKPQDQ
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sequence:
MNSFSNDEFDFNFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWYKALPRVTPFYAVKCNDSRAILKTLAAVGAGFDCASKTEIQLVQSLGVPPGRIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLSIATDDSKAVCRLSVKFETFVQAVSDARCVFDMGAEFGFNMYLLDIGGGFPGSEDVKLKFEEISSVINPALDKYFPPDSGVRIIAEPGRYYVASAFTLAVNIIAKKLVLKEQTGSDDEDEANDQTFMYYVNDGVYGSFNCILFDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQCMQQIKNQGFPAEVEDQDINTLPLSCAWESGMEHHSTTCTSASVNV