lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDLSCQDSLYPKYQGDSELKEEGVQSTDPGAPQQLHERKQEQTIGPLSSGDFADNGETSDYFFLSSQPSPPLPLNYSGSFFIETNPEHSQDQETLFSIMSGILGISPFSAPQQLNRQESLYSVPEAIQNHMDLYSNSQPNLSISVQQPYQNQLYSAFSSTEDIHQVPSSPSLGSSCSSQCFFDSKLVPNKHELDFSPISPSMDSFGSQCPRWEAQNGQSFATSSFQLDSFHQSNNPQSVFHPLESKVENMLSACCQPHATEISEDSAHFSSMDFTCQSDSYQTSHLDFSETNMDLKPQLLGDLKYQFGHQVATPGPTNQEELIHHSSPPLISTNFLGHSPTEGNMLPSHAGEPSVEPRKKYRRNKFPAKCFRPKPHEKAFACPVESCIRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHIRTHTGEKPFSCDLCGRRFARSDEKKRHGKVHMKQKARTEEKLKGLGFYTVGLSFGTL
The following text describes a protein:
Function:
Expression of the ptox operon (ntnh-orfX1-orfX2-orfX3-pmp1) in B.thuringiensis kills Anopheles but not Aedes mosquito 3rd instar larvae. The ntnh-pmp1 construct is about half as toxic.
Miscellaneous:
MISCELLANEOUS: P.bifermentans strain Cbm (subsp. malaysia) is toxic to Anopheles mosquito 3rd instar larvae and less toxic to Aedes aegypti larvae.
Domain:
A beta-sheet wrapped around a long alpha-helix. Structurally similar to tubular lipid-binding (TULIP) superfamily proteins. The structure of OrfX1-OrfX3 is very similar to OrfX2 from C.botulinum type A2 (AC C1FUH4, PDB:6EKV).
Sequence:
MNREFPFHFNDGNVSMNGLFCLKKIKTQYHPNYDYFKIKFCEGFLSIKNKVKDDLCEYDLKNIESVIALKREYSKENNLKNKESAIFMNIGNKGIHNKYDLYVVNVDINNILDENYMLKGILNDKLKILFLGNERKLLRIKN
The following text describes a protein:
Function:
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
Subcellular Localization:
Cytoplasm.
Sequence:
MLWSIMSKPLDLNQLAQNIKQWGLELGFQQVGITDTDLRASEPALQAWLDKQYHGEMAWMARHGMMRARPHELLPGTLRVISVRMNYLPANAAFASTLKDPTLGYVSRYALGRDYHKLLRSRLKKLGEQIQQYCGSLNFRPFVDSAPILERPLAEKAGLGWTGKHSLILNREAGSFFFLGELLIDLPLPVDQPVEEGCGKCVACMTICPTGAIVEPYTVDARRCISYLTIELEGAIPEAFRPLIGNRIYGCDDCQLICPWNRYSQLTDEADFSPRKALHNPDLLELFSWSEAQFLKVTEGSAIRRIGHLRWLRNVAVALGNAPWSNAVITALESRKGEHPLLDEHIEWAIAQQIEKRNACIIEVQLPKKQRLVRVIEKGLVRDA
The following text describes a protein:
Function:
Transcription factor. Binds to DNA sequence motif 5'-CATNNNNAAATGCAT-3' as a heterodimer with egl-46. Represses expression of genes involved in differentiation of touch receptor neurons (TRN), probably acting as a heterodimer with egl-46, perhaps by occupying similar cis-regulatory elements as an unc-86/mec-3 heterodimer. Plays a role in cell fate specification of neurons, including the hook neuron HOB, and touch receptor neurons. Involved in male mating behavior, acting in concert with egl-46, via modulation of expression of polycystins lov-1 and pkd-2, homeodomain protein ceh-26, and neuropeptide-like protein nlp-8. Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Plays a role in neuron differentiation by repressing the expression of zag-1 in FLP neurons, probably acting as a heterodimer with egl-46; because zag-1 represses expression of egl-46 and egl-44, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. Plays a role in specifying commissural dendrites of the PVD nociceptive neurons, acting in concert with egl-46. May be involved in thermal stress response downstream of yap-1.
Subcellular Localization:
Nucleus.
Sequence:
MNSMFCSELQQALPQMSEDVAVTAQTILNGTPPHNHFRKEWLAGAAGTTTPTTTSGGQMMTLSPPAGDGPGSAGSMAPESTSSLSDLSGDAEGVWSIDIDQAFQEALAIYPPCGRRKIIISDEGKMYGRNELIARYIKLRCGKTRTRKQVSSHIQVLARKKLRDEQAKKKGDIPSLLQQASPPGGVKSPSAVVFPPVSAAVAAITEISPQSSYSSIVPKVETDQISQQLFKSLPLWSFQQTPGLPIGMDLSQLVFQQSSPDKTVSPVKSEVVEETKPIASSQLTLHSFSAYVKCNKTSLRTELVKIENTLEKDDIDISVFYEKYPKLLRELFEKSEKKDVFFLAKCWANINVSDDVQNCQYAVDSFYSSREKFQLKVSTMACSFGNQAVEKIEQYFPIEFDGSYSFILNNSPMCDYMVKFIAELKKLNVIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPSCSVYRLIDGGGDSDE
The following text describes a protein:
Function:
Binds calcium. May be involved in terminal differentiation of keratinocytes.
Sequence:
MAGELTPEEEAQYKKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSDGDGEISFQEFLTAAKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEELDAMIREADVDQDGRVNYEEFARMLAQE
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVQQLSLYSVIDEGSFDLLIATISALSGRSPVLFANYNHVAHPNPNYAIEKVNAKNQLVEQTRVQLMQEIPFEKLQTEEYSYKLCTKMTGDGPPIETEYLNSLMRSCGDGTRPWSLSLWDIPSAGKDRKVCTQAVVESVVTSTGGAHSSILSFLAELGYVPGYQFVQLGTQFYLENGIVFQISKLWALHGESGKTSAVTKDGFLIKAYLNVPKATDLESINQGTAHLQQLKRELRDYLELSIPDRKSMDSRVGHLNDF
The following text describes a protein:
Function:
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Sequence:
MPVRLDRSSADFDQRFAAFLAAKREVSADVEAAARAIVDDVARRGDAALLEATAKFDRLTLDASGLRVSAAEIEAAVKACDAATLDALSLARDRIETYHRRQLPKDERFTDPLGVELGWRYTAIESAGLYVPGGTAAYPSSVLMNAVPAKVAGVSRLVMVVPSPDGKLNPLVLAAARLGGVTEIYRVGGAQAVAALAHGTATIAPVAKIVGPGNAYVAAAKRLVFGKVGIDMIAGPSEVLVIADDTGNADWIAADLLAQAEHDTSAQSILITDSARLAADVEKAVEAQLKTLPRTAIASASWADFGAIIMVKNLNDAIPLADAIAAEHLEIMTTDPDALAARIRNAGAVFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLSVHDFMKRTSILKCGPDQLRALGPAAMTLGKAEGLDAHSRSIGLRLNLS
The following text describes a protein:
Function:
Acts negatively to control the expression of luminescence. At low cell density, LuxO is phosphorylated, and together with sigma-54, causes repression of the luxCDABEGH operon. This repression could be indirect, LuxO could activate a negative regulator of luminescence. At high cell density, LuxO is dephosphorylated and inactive, therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype (By similarity).
Sequence:
MVEDTASVAALYRSYLTPLGIDINIVGTGRDAIESLNHRIPDLILLDLRLPDMTGMDVLHAVKKSHPDVPIIFMTAHGSIDTAVEAMRHGSQDFLIKPCEADRLRVTVNNAIRKATKLKNEADNPGNQNYQGFIGSSQTMQQVYRTIDSAASSKASIFITGESGTGKEVCAEAIHAASKRGDKPFIAINCAAIPKDLIESELFGHVKGAFTGAANDRQGAAELADGGTLFLDELCEMDLDLQTKLLRFIQTGTFQKVGSSKMKSVDVRFVCATNRDPWKEVQEGRFREDLYYRLYVIPLHLPPLRERGKDVIEIAYSLLGYMSHEEGKSFVRFAQDVIERFNSYEWPGNVRQLQNVLRNIVVLNNGKEITLDMLPPPLNQPVVRQSVAKFIEPDIMTVSDIMPLWMTEKMAIEQAIQACEGNIPRAAGYLDVSPSTIYRKLQAWNSKDEKQNV
The following text describes a protein:
Function:
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (By similarity). Plays a role in regulating nuclear envelope (NE) morphology and nuclear integrity, particularly during spindle pole body (SPB) extrusion or insertion through the NE, and perhaps during karyokinesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKKEKVNALEFSVNKGIFTKTRLKSLYSDFTSLFIKNPEGFLANVNTWREAIETSAWSGKLNSRIILVFDETFESAFSSPALGRPLSLGAVAAYWIQQGVWLRKQDFLNDCKKGNLVREDGFSIFSILRWSFQKLGFQNQASSILSNRSPSGQYVIRKNIEKLACLVHNEAMRRCSSYTSAIYTWDFFQDTFGSLYWEEGKLNKDEMECLLNWMCYQKHVLIFDSKIIKFLPNSQIDAQLASIDKSIDGSVADLIQARASIAQRSEFLNEELEQLSQVLNQAVKKGEKTIAITYLRRKKILSKDLERKVSSRLQLDTIISNIDNAVDNKILLIAMSSGSEALDAILAQMGGTEKVEDVLENVNDTLARSEEIDATIQTYNPQNIDLEDEAVEKEWQDLVAEEQKVEDIVSTLGNVSLKTPSDTFTLTNTDSDKKTSKPEKIQAELVEQ
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG2 is required for ER to Golgi vesicle docking. Not essential for viability.
Miscellaneous:
MISCELLANEOUS: Present with 3270 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDFLNDDELDLDLPVTAEISKELFATEIEKYRESETNGTDVDNFDVDRFLVQKNFHYLPLDSLIRDLSGLSQKMVQTLLEQIRSNYDDYLTFSNTYTDEENETLINLEKTQSDLQKFMTQLDHLIKDDISNTQEIIKDVLEYLKKLDEIYGSLRNHSQLTEALSLGKRLSKSLHEMCGIEPLEEEICSGLIEQLYKLITASRRILESCADSNSPYIHHLRNDYQDLLQEFQISLKILTEKCLENPSSLQNLSLTLVSIIKTA
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Domain:
The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.
Sequence:
MVQCTDCKKWRLIPSMQHYNIIKETQLQTPFVCGTTSGWTPNMSCNVPQDGTTCDTWPSIPPIPTGWSRSVHIRSESTKFADVYYFPPSGERLRSSAEVQSFLDNHPEYVREGVNRSQFSFQIPKPLDDNYVKKRTRPVKRRKSSKDNNCEKGKK
The following text describes a protein:
Function:
Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development. Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF. Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism. Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts. In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production. However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1.
Subcellular Localization:
Cell membrane. Golgi apparatus membrane; Single-pass type IV membrane protein. Lysosome membrane. Mitochondrion outer membrane. Note=Accumulates on the mitochondria after virus infection.
Sequence:
MISPDPRPSPGLARWAESYEAKCERRQEIRESRRCRPNVTTCRQVGKTLRIQQREQLQRARLQQFFRRRNLELEEKGKAQHPQAREQGPSRRPGQVTVLKEPLSCARRISSPREQVTGTSSEVFPAQHPPPSGICRDLSDHLSSQAGGLPPQDTPIKKPPKHHRGTQTKAEGPTIKNDASQQTNYGVAVLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSWKGQLNEDKLKGKLRSLENQLYTCTQKYSPWGMKKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQGLLQNQSLQLQEQEKLLTKKDQALPVWSPKSFPNEVEPEGTGKEKDWDLRDQLQKKTLQLQAKEKECRELHSELDNLSDEYLSCLRKLQHCREELNQSQQLPPRRQCGRWLPVLMVVIAAALAVFLANKDNLMI
The following text describes a protein:
Function:
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA; Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MSLSRIVYVLLLFIASWSLYYLLGQEQDSKIQVAPNLELPMFSGENLENISYDEQGIRNYVITSIHLDHYAKSGNTLFKAPILKVYREGTLQEWEITARRGILSKDQVLTLYDDVLAKNLLPDSGFDTLTTSEMSIQLKSRDFWADKPVELRGPQFETHGQAMKGNFADHSAELYNQVQGRYETLTP
The following text describes a protein:
Function:
Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.
Sequence:
MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFSDPLVELLSDHPESQYDLLETRHALEGIAAYYAALRSTDEDKERIRELHHAIELAQQSGDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFELLYSRREMLPLVSSHRTRIFEAIMAGKPEEAREASHRHLAFIEEILLDRSREESRRERSLRRLEQRKN
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MIDKLELLLALAKERHFGRAAEACGVTQPTMSTGLKQLEEILGVMLVQRGSRFQGFTPEGERALDWARRIVGDARAMRQEINSLKDKLSGEIRIAAIPTVLGMVAALTTPFRARHPEVRFRIQSTTSSEVLGLLENLEVDAGLTYIENEPIGKVRTIPLYNESYRLLTAPDAMFGDRETVTWTEVGQVPLCLLTPDMQNRRIIDRALRSVGAEATPTLTSNSLLVLFTHVKTGRWASVMPAKLAETLGLSDTVRSIPIVDPEVNYSIGMVIPQRDPMTPLIAALVNVAREVAPTLQL
The following text describes a protein:
Function:
Involved in RNA editing event in chloroplasts. Required for the editing of a single site in ndhD transcript, which is a plastid-encoded subunits of the chloroplast NAD(P)H dehydrogenase (NDH) complex. Not essential for the activity of the NDH complex of the photosynthetic electron transport chain.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAISSASLISSFSHAETFTKHSKIDTVNTQNPILLISKCNSLRELMQIQAYAIKSHIEDVSFVAKLINFCTESPTESSMSYARHLFEAMSEPDIVIFNSMARGYSRFTNPLEVFSLFVEILEDGILPDNYTFPSLLKACAVAKALEEGRQLHCLSMKLGLDDNVYVCPTLINMYTECEDVDSARCVFDRIVEPCVVCYNAMITGYARRNRPNEALSLFREMQGKYLKPNEITLLSVLSSCALLGSLDLGKWIHKYAKKHSFCKYVKVNTALIDMFAKCGSLDDAVSIFEKMRYKDTQAWSAMIVAYANHGKAEKSMLMFERMRSENVQPDEITFLGLLNACSHTGRVEEGRKYFSQMVSKFGIVPSIKHYGSMVDLLSRAGNLEDAYEFIDKLPISPTPMLWRILLAACSSHNNLDLAEKVSERIFELDDSHGGDYVILSNLYARNKKWEYVDSLRKVMKDRKAVKVPGCSSIEVNNVVHEFFSGDGVKSATTKLHRALDEMVKELKLSGYVPDTSMVVHANMNDQEKEITLRYHSEKLAITFGLLNTPPGTTIRVVKNLRVCRDCHNAAKLISLIFGRKVVLRDVQRFHHFEDGKCSCGDFW
The following text describes a protein:
Function:
Hydrolyzes cellobiose 6'-phosphate into glucose 6-phosphate (Glc6P) and glucose.
Miscellaneous:
MISCELLANEOUS: Is a retaining glucosidase as it hydrolyzes glycosidic bond with retention of anomeric configuration. Reaction mechanism includes redox steps involving NAD and stabilization of intermediates by Mn(2+).
Sequence:
MRIAVIGGGSSYTPELVKGLLDISEDVRIDEVIFYDIDEEKQKIVVDFVKRLVKDRFKVLISDTFEGAVVDAKYVIFQFRPGGLKGRENDEGIPLKYGLIGQETTGVGGFSAALRAFPIVEEYVDTVRKTSNATIVNFTNPSGHITEFVRNYLEYEKFIGLCNVPINFIREIAEMFSARLEDVFLKYYGLNHLSFIEKVFVKGEDVTEKVFENLKLKLSNIPDEDFPTWFYDSVRLIVNPYLRYYLMEKKMFKKISTHELRAREVMKIEKELFEKYRTAVEIPEELTKRGGSMYSTAAAHLIRDLETDEGKIHIVNTRNNGSIENLPDDYVLEIPCYVRSGRVHTLSQGKGDHFALSFIHAVKMYERLTIEAYLKRSKKLALKALLSHPLGPDVEDAKDLLEEILEANREYVKLG
The following text describes a protein:
Function:
Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.
Subcellular Localization:
Nucleus.
Sequence:
MSSGAGSRRPREPPEHELQRRREQKRRRHDAQQLQQLKHLESFYEKPPPGFIKEDETKPEDCIPDVPGNEHAREFLAHAPTKGLWMPLGREVKVMQCWRCKRYGHRTGDKECPFFIKGNQKLEQFRVAHEDPMYDIIRENKRHEKDVRIQQLKQLLEDSTSDDDGSSSSSSGDREKRKKRKKKEKHKKRKKEKKKKKKRKHKASKSSESSDSE
The following text describes a protein:
Function:
In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MSFKELVEPECGGANPLMNLGRQVRKDVALQDEGLAGGRSSFAGGDRELVNEFMGQIAPVPQTFRMNELLQEMREIDAQNHRQQQIVGAGRSIEFAPGDAAWADQFRGEMMVESKLSSVWSQSNMAPIQTNTAHPLQRPANQEFLNSYERNQMPSVRMAANEMMYQSMAGQQMMGNPNLQQSQFVRFMNNVSTGNVLINDGQVSSSVWENRFDELEASSSKGKQEQQEQKGQEQAQKPEDDWAKAFEAEKQEQDEASDSYNKQFWERLQDEWRTLAEGEGKHPWLSEFNDFYDPFKEYKFDEENPMADVENAFEKGKAFLAQGDIPSAVLCFESAVKQDPENPEIWEQLGFAQAENEKDPNAIAAFNKALSFNPNNMPVLMALAISYTNEVLQNQALRMLIRWMKCNPKYEQLVPPEMLQAQESPVASSFMGGPKLQDVQELFIKAVQQSPTEIDADIQEALGVLFNLSSEYDKAVDCFQAVLQVRPDSSKAWNRLGASLANGNRSLEAVTAYQRALDIQPGFIRARFNVGIICVNLKAYKEAAEHLLTALNLQATSATRSGLKVNSMSQQMSSAIWTLLRMVLSLMSRQDLHTAIDNRDLEVLNREFPMSND
The following text describes a protein:
Function:
Exo-fructosidase that can hydrolyze both levan and inulin, leading to the production of free fructose. Is also able to hydrolyze sucrose and to a small extent raffinose, but not melezitose, stachylose, cellobiose, maltose, and lactose.
Miscellaneous:
MISCELLANEOUS: Levanase cannot be detected in the wild-type B.subtilis but is mostly secreted into the culture medium by SacL mutants, especially at the end of the exponential growth phase.
Subcellular Localization:
Secreted.
Sequence:
MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEANWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKGTIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNPVIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSHGGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPPNKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPRELKLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKVSPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKPVNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHPLKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITIKDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNKKYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (By similarity). In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). Essential for diploid cell cycles, organ growth and development. Regulates mitosis by binding to Xpd and thereby competing with the Xpd-mediated repression on the Cdk-activating kinase (CAK) complex. Regulates the centrosomal localization of the MT regulator tacc, a downstream target of aurA kinase. Binds to microtubules (MT). Regulates spindle and astral MT growth, MT stability and bundling. In neuroblasts, necessary for timely and coordinated spindle assembly and orientation which is necessary for mitotic progression. In young embryos, the maternal protein is important for progression through mitosis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm. Midbody. Note=Localizes to the nucleus at the beginning of metaphase.
Sequence:
MTTPTRATLEKALKSDQKLVNSATQIAKDLTAKAYDISALAEALGFALSSPDMEERVAGTNLLSAVLIALPQDLLQERQLEFLSTFYMDRLRDHHNVMPAIIDGIDALVHMKALPRAQIPQILQSFFEHTTCQSQTRSDRTKLFHIFQYLTENFQDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFMPEFLSTYPLLHLAEEMFEIFACYFPIDFNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLVAKLDSIELLHQAAVKFPPSVLEPHFDQIWQALKTETFPGNDNEEILKASLKALSALLERAAHIPDISHSYQSSILGVILPHLSDVNQRLFHPATGIALVCVSGDAPYAADKILNSFLLKLQAADASSEQRIKIYYIVSQVYKLSALRGSLQKLDTTIRESVQDDVIASLRLIEQEEFDAKKEDLELQKAALSVLNESAPLLNEKQRALIYKALVQLVSHPSIDIDFTTLTVSLGALQPVEVQSNFIDVCVRNFEIFSTFVKRKIYTNLLPLMPQIAFTQRILDLVMTQTFNDTTAEPVRLLALEALNKLLLLADQRFIVDVQQESNLLHKLIELGQKTEGLSMQSLEQIAGALSRITQQLPLSEQSAIVSEYLPGLNLSQSADLYITKGLLGYLHKDITLDDHFERLLTDLTQLSLNSDNEQLRVIAHHLLCSMVNKMESNPANLRKVKKITEQLKVAIKKGDVRAVEILAWVGKGLVVAGFDEAADVVGDLSDLLKHPSLSTAAALGFDIIAAEYPELDLPVVKFLYKQKLFHTIMGKMGSKLANYCVHHLKAFVYVLKATPQAVIKLNIEQLGPLLFKSLEEHNEAQSLCIALGICEKFVAQQDTYFQGHLAHLIPSCLELSKYKAQHTMQVRIAALQLLYDVTKYPTFVLLPHKVDVTLALAAALDDPKRLVRNTAVKARNAWYLVGAPSPN
The following text describes a protein:
Function:
Regulatory protein of the TOL plasmid xyl operons. XylS activates the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m-xylene and p-xylene.
Sequence:
MSHANTPRDWVRRAPQHGAVERIEAYFAGHGYDPHRHDTYAIGQTLAGVQSFRYRRSQRHSLPGGCLVLHPDELHDGEAGSQEGFRYRMLYVEPALIQQALGGRPLPFVRGGLSDDPRLIAASRALLQAMDTPLEPLEEQDALFELAHALDAVAGNRARGRRHFDFVAAERARQYIHAHLERPLGLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLMLGGQTLAEAALAAGFADQSHMTRHFGQSYGLPPARWLRMLGRA
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSKRRKLDSSIKPQLSAVSAFAARKAQAAAHSTGSPEKETTSSEDHPKKLSQDVKIDFPSRSLNRGKSSQVGNDFPSISAGFIAEGSGLGEDIGNHVMRTLVLKLAPGERLVILGQCNLEVAEGQITILGSILKASKTKYQVYAAASHSLPVIRCPDGELNPAVLRLHQSDCGLRSLDSLSPLFGKLWNEDTRAFKSAHSRLSAKLGKSTFQIVHKSYLQPITSPPEWNKTLSKLSGTPGATKRIMLCGPKSSGKSTFAKFLVNRLLSASQNDAQSSTPNSRKGPGVALLDLDPGQPEYSHPGQVSLIHIQEPNFGLSITHPVPGIKSRLIRAHALGAISPSMDPSLYMSCALDLFAHYRNLSSLHFNCPLVINTPGWVLGTGLEILVDLIAKVHPSEVIYMSKEGPAEVVESLQDAAKTTPLITLPSQTSEFMTRTSAHLRTMQSMSYFHLDSTNKNELAWSSTPLTSIPPWEIKYSGENAGILGIMCYGEQPPPDLLAETINGSIVSVVVIEEAAAIPGYTSFQQEKDEQSDPETLHEFNSPLTLDPIKTPLIIPTPHERLPYFNPLNAITLDPQFSHTIGTALIRGIDINRQRLQVLTPISPEVLEELNDENKKIVLVSGKLDTPGWAYTEELMKRMWLEKEKRRNELHGNDDDDEVEVEKDEDEDEEEDKEEDEEDLPTPNSTSSSSSSSSSSSSNNTTITFRHHTPWVEKLTGSQGRGIGARVWRVRRDLGKMDA
The following text describes a protein:
Function:
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Sequence:
MELVAVKEGLARILVPKAERIYDAPVFYNPVMSLNRDISVLAVKVLGPKRVLDALSATGIRGIRYALETPAEEVWLNDISEEAYGLMKKNASLNIDGELYEEGDRSYLWGEKLVVINKGDANRLMAENFRYFDFLDLDPFGSPVEFLDTALRSVRRNGVLAVTATDTGVLCGAYRNACLRKYLAEPIRGPLCHEAGLRILIGTVVRYAAKYDLGVEVLLAYHRDHYFRAFLKLKSGAKKADKSLSQLGFLWADKSGRFEYRRGFLPDKPGASGPLWLGPLKDESFVEELLESARDHPLAHKKTLSFLQLISEELDVPFHYDTHTLARACSLTPPKLDVIIQRLRELGHSATKTHFSPTSVKTDAPFGVVAEVMKNV
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Sequence:
MVMPTKISHADENTLSTVKEMALNTENAIALAGDAAPVVLGAGGKPLPPPYKSTGNEALDTLAFLHMLEQLKIQKRSGWIREGVKQAESISDHMCRMALMAMMLPNSSERPLDIPRCVMMALVHDLAEAYVGDITPVEGVPTHVKHQLEEQAMDTFLNEMLGGKGNKDARERFRSLWDEYEARETPESRLVKDLDRIELALQAVEYERSQDIQTLDPFFKGSIPNLEHPVTRQWAATLMEERRQLWTSRGRTHEGLGDWET
The following text describes a protein:
Function:
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MGRSMLPEQQEDVSRKSKKEKKSKKDKKRKLEAEAEVVVVEAAAATSTDEATKSSKKKRAKGDLGQGEEAENGGGKVVAVTGKGSADAKYAPLSSFAATALPPQVLDCCKGFERPSPIQAYAWPYLLDGRDFIGIAATGSGKTIAFGVPALMHVRRKMGEKSAKKGVPRVLVLSPTRELAQQIADVLCEAGAPCGISSVCLYGGTSKGPQISALKSGVDIVIGTPGRMKDLIEMGICRLNDVSFVVLDEADRMLDMGFEPEVRAILSQTASVRQTVMFSATWPPAVHQLAQEFMDPNPIKVVIGSEDLAANHDVMQIVEVLDDRSRDSRLVALLDKYHKAQRNRVLVFVLYKREATRVETMLQRRGWSAVSVHGDKAQHDRTKALSLFKEGSCPLMIATDVASRGLDIPDVEVVINYSYPLTTEDYVHRIGRTGRAGKKGVAHTFFTQENKGLAGELVNVLREAGQVVPPALTKFGTHVKKKESQIYGSHFKEIKADAPKSTKITFGDSDED
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MVLKLRLARFGRTNAPFYNIVVAHARTARNSKPLEVIGTYDPVPKKDTYDTTGKLHKDIKLDVTRAKYWIGVGAQPTDTVWRLLSLVGILDPKYKKPQPAQEQKTKA