lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The N-terminal region is required for orexin signaling.
Sequence:
MSGTKLEDSPPCRNWSSAPELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTMLPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQQTKSRISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLARGRTSTESRKSLTTQISNFDNISKLSEQVLLTSMSTLPAANGAGQLQNW
The following text describes a protein:
Function:
Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes. Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP. To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation. Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes.
Sequence:
MRLESVAKFHSPKSPMMSDSPRATASDSLSGTDVMAAMGMAQSQAGFGMAAFCGKHELSQNDKQKAINYLMQFAHKVSGKYRGVAKLEGNTKAKVLQVLATFAYADYCRSAATPGARCRDCHGTGRAVDIAKTELWGRVVEKECGRCKGVGYSRMPASAAYRAVTMLIPNLTQPTWSRTVKPLYDALVVQCHKEESIADNILNAVTR
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKIDLMVTVIGVWKYIIRHENMYDVINLHLIALKICGELFVCRNRSTGQLYVSWKSFASFVAQLICLIMLVVGGYFAQRSYGKEDATYLHRGTSILIRFSGVFAVVIAISNAIVGRRIWAILDCFDRFDKRMQILNAPVDHRTQKLVIVAWTLMFVVGVSSFMLGFVFAISTNYSNMLLRIVTITQIIIFVMVIVSILCQIVIVMYLGSYRFYHLRRFYEVNFLPWKTGSILLSELTSVNQFRRLADSTSFNTVMELYGTLREAVRLMHRAYSVQLLSMTVSNFPTPTLALFGMYRSFMTSNYDMQNLIITMAASSMMYLMAYFLLIFLSTSIKYETQRLIECFHHFTNLNNVEFESMIKVSADEVNRDNVALHVGPVELNWKLAFSMIGTIISYLVILIQFDRSSAG
The following text describes a protein:
Function:
Catalyzes the sulfur transfer reaction from thiosulfate to cyanide, thus converting cyanide to the less toxic thiocyanate. Contributes to P.aeruginosa survival under cyanogenic conditions, and thus provides the bacterium with a defense mechanism against endogenous cyanide toxicity. Is the main cytoplasmic rhodanese in P.aeruginosa, accounting for 90% of total rhodanese activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MSVFSDLPLVIEPSDLAPRLGAPELILVDLTSAARYAEGHIPGARFVDPKRTQWGQPPAPGLLPAKADLEALFGELGHRPEATYVVYDDEGGGWAGRFIWLLDVIGHHHYHYLNGGLPAWIADAQALDREVPAPVGGPLPLTLHDEPSATREYLQSRLGAADLAVWDARNPSEYAGTKVLAAKAGHVPGAINFEWTAGMDPARALRIRADIAEVLEDLGITPDKEVITHCQTHHRSGFTYLVAKALGYPRVKGYAGSWSEWGNHPDTPVEV
The following text describes a protein:
Function:
One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
Sequence:
MNYSSLLKIWVSFIFALVRHQVQPRELMYPFWQNDTKTPKVDDGSSSEIKLAMPIFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFIAPFWADVHNGIRGEIYYRETMDPVILKRATKDIRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTNFFSLPGSRTPDIVNIQETTNVNVPGRWAFKIDGKEIDPANGCTSRGQFLRRGEVFWDDLNCTIKCRCLDFNNEIYCQEALCSPYEVCEPKGKFFYCSPVETSTCVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELLVEVNGYKILIPKGSYGKVKVNDLVASLPITLDLGAVKIYQSGMSTAVETDFGLLVTFDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCDSGCVDNCTQCDPATEALYFGSDYCGFLNKTDGPLGECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGCVSTVQCPNFSHYSVCTSSCPDTCSDLTASQNCAVPCTEGCECNEGFVLSTSQCVPLHKCGCDFDGHYYAMGEFFWATANCTVQCLCEEGGDVYCFNKTCRGGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPAEFSYTLLKTCPEGPEYLEIDINKKKPDAGPAWLRGVRILVADQEVKIGGLGAAEVKLNGQEVELPFFHPSGRLEIYRNKNSTTVESKGIVTVQYSDVGLLYIRLSTAYFNCTGGLCGFFNANASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGLINDPSNSSFLECHSVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTHDFCPLECPENSHFEECMTCTETCETLALGPICVDSCSEGCQCDEGYALQGSQCVARSECGCNFEGHQLATNETFWVDLDCQIFCYCNGTDNSVHCETIPCKSDEYCLEEGGLYYCQARTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSRPSSDTFPKFIVTAKNEDRDPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNSERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVVYDWKTFLSVTVPRSLQNSTSGLCGRYNGNPDDDLELPMGVLASSVNEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVHQLCSLIPSQNSGFTKCHSKVNPTFFYKNCLFDSCVDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTSCSVTCPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLNGKSCILPHSCGCYSDGKYYEPKQLFWNSDCTRRCRCFRRNLIQCDPRQCKSDEECALRNGVRGCFSTKTSYCLAAGGGVFRTFDGAFLRFPASCAFVLSTICQKLPDISFQLIINFDKWSSPNLTIISPVYFYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSREGFLVIDTSPDIQIFYNGYNVIKISISERLQNKVCGLCGNFNGDLTDDYVTLRGKPVVSSVVLAQSWKTNGMQKRPLAPSCNELQFSQYAAMCDNVHIQMMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNQKKFQLCGSLAAYGESCRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELENGGELCGCIEPPPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRVNDRQCTGIEGEDFISFQINNTKGNCGNIVQSNGTHIMYKNTIWIESANNTGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLYVGVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIGIEENGVSLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKINCPQNSRIATDYTKEPKEQIISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLCSCVTGTLQADGKSCRASNSSIELQIWTLLLLMTQISLWRFVYKSGMTS
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTTVDFSNQTDHTTVTHHNNTHTHSFSLTINTSLSLAAIFTPVMFGDVLCDRPKPWFLCPSLFTCHYSSVAHRLHGSDCGFPIKLLGPANGFCDMILRDGHDYCSSPVGEGSWNVAWDMRPARWLHRPHTAWLLFGICAYLAPPPVDFTDAVLKSVDINDERVDGSVLEDSANYRVTGVPADGRCLFRAIAHMVCLRKGEDAPDENRQKELADELRVQVVDELVRRQKEIEWFIEGDFDAYVKRIEKPFVWGGEPELLMASHVLKTTISVYTFERGSNNLSKIATYGEEYEQDEISSIKVLFHGYGHYDILEDKF
The following text describes a protein:
Function:
3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MKSEIEIELGADDPLSKSTARLSICQADMEEETEGNQNPRLQVRELLQREKESIQRRDSAVSLNSFLEEDEENDQQQSQSQQQHLSPKKKSRSKKAAEKRRRSSAHSFSIAQQQPPLKREKVHKRKLKKRLQPPNIELLLDKSEENSNKDSELKRFPFRNLRSLILKVFNVPGTNNLKWCNIENSEKIPTVCVCLVPGLQLEENLAETADNGLQSSKEKSKQQCAISNLKRIDQLSFIFDNFTNFIKSSSPGSKDSIFSSLQTLLNVPLTKNEKNSLLRKSKATKITIKDLLLTEQQLKTYNYPTTLVDSTWKATKDLYNTDSNNNEKSDSETRKSRIYALDCEFCKAGAKQVLTRISLLDFEAKVVMDELVKPKEEITDYVTKYSGITEELLRDVTTTIEDIQNLFVNTVSQQDILIGHSLESDLNVMKIKHDNIVDTSIIYEHNRGPPSKPSLKSLAEKHLNRQIQAGEGQGLGHSSIEDAKACLDLVKLKIIEGKLFGVNVGEVSIFQRLSENPNYNAGGEVNPSSDTDGNNTFKSLLVSYGQTREYDINPDEKYDLTKINVTNDDEAVENFVKEIHSKNFAVINLRDSEFNNKWNTPPDYYKGDLDYNQMESYKRTNQRLEKIYQSLPDHSLLICYSQSGDPREMFKLQGVRRNFQKCEKEGIVDVTKLPEEESWTFTKSEKLLEQTSLARESLMFIKIKPSSDTGSYSINNLSTETITSVTPEISGGGGGSSSSNKDIE
The following text describes a protein:
Function:
May bind RNA.
Sequence:
MKRVSSSMSSDDIVLEDLETEGERQLRSPLHHQLDTSVSIEECLSKRQCFAPAALYKPFGEVAAGALTLSQFQALQESDRETASLRELGLTDAEISLWKNRASEAKSAGLGAAPEATLERLRNIEEKISERQRILSLPQRFAGSKQLNRREMEIENALFQGTDRHSFLRALYYQDEARQRVQKDPMSDLETVYQEILTQTPQEPHDPTQVASASRSAAPEAPGTPGRGREAAEDTSEPRRQDGRAAQDEAPGLPGPETPQHASAAPRKVTEPVAFVPEDEIRRNRLSEEEIRKIPRFSSYSPGEPSKVLYLKNLSPRVTGKELVSLFAQFQEKEGPQIQFRLLTGRMRGQAFITFPSTELAQQALLLVNGFNLLGKTLVIEFGKNKMQPTGLLSAPLPAEATSGLEKPRSS
The following text describes a protein:
Function:
Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKLLENSSFEAINSQLTVETGDAHIIGRIESYSCKMAGDDKHMFKQFCQEGQPHVLEALSPPQTSGLSPSRLSKSQGGEDEGPLSDKCSRKTLFYLIATLNESFRPDYDFSTARSHEFSREPSLSWVVNAVNCSLFSAVREDFKALKPQLWNAVDEEICLAECDIYSYNPDLDSDPFGEDGSLWSFNYFFYNKRLKRIVFFSCRSISNRPGVGSPKTSSHTSPSGSTYTPSEAGNELDMLLGEEEEEEEEEEEEEDGGGGGSEGGPEETSAMEEDRVPVICM
The following text describes a protein:
Function:
Essential for normal male fertility and for progressive motility of spermatozoa.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MSKNSRVKVVVRSKPTANFAHEFMKIEPDHKTIVLHDEKATDNSFINNKVHDWTFNVDKVLHNASQEAVYDECGKDTVSKALNGYNSTIFAYGQTGAGKTFTITGTTENYKNRGIIPRAIAQIFQHVKEHTDTAYNISASYLEIYNETMFDLLSTLPEQKLYQHEQLQPMSVVEDPNGSTSVKGLRVQCITSEEEALNLLFEGETNRVIASHALNKSSSRSHCIFTVYIESRSRVDSMAKVISSKLHFVDLAGSERLGKTGSRGDTQKEAVYINKSLTFLEQVIIALADKKREHIPYRQSKLTHVLKDSIGGKCNTLMIANIWGESSQIEETSSTLRFAARVMCVPSEPALNIHYDAAQLILQYEKEIKALKLELAMHSTLANRGKISYDPISELRLQEIRREVRAFLSGQLETIEIESVRQVKAVFQEFKNQMR
The following text describes a protein:
Function:
Probably plays an important role in intracellular peptide degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVALTGEGWDTERCWAFWAGYKGPKGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEELGPEQLAQRAVDLLCSVACDSVTYRITKGEDLREQNYMGLHTVGRGSERPPVLLALDYNPTGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLIIDMATLTGAAKTALGNDYHALFSFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSATYRKAPVEQWAAGATGLGVRTIANLLTA
The following text describes a protein:
Function:
Recruits the lipid transfer protein Vps13 to mitochondria thereby promoting vacuole-mitochondria contacts. Involved in mitochondrial lipid homeostasis.
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MIKLHEVPPEPVDPASLPHDVNAHSPEGDGNPDKRKKIFGIPYPFSRSSCRRFLWNCQKISVLPMALYFPLHAANTLITPAVSPDSAPDDVLMMVREILPSITTKLLVAGITLHVSAGVLLRIVNNWNKPRRNRHRHLKISAEQDLSQDSIGLTGGISGYLFGLYKTFRIPPQVISGYILVPVLIYHLLIMKWVPNSISTEVDFASIKQLLSSKNRWWKWLGGLVPLAILLESGVYHIGSGLCRYFGVRKMTSRKKWSTAINLLTLVGFVSLIRLMKEDSTKLGPNQFESIFKKIRLLLHVN
The following text describes a protein:
Function:
Forms a receptor-activated non-selective calcium permeant cation channel; [Isoform 2]: Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The cytoplasmic portion of the protein is required for channel assembly and gating.
Sequence:
MSTKVRKCKEQARVTFPAPEEEEDEGEDEGAEPQRRRRGWRGVNGGLEPRSAPSQREPHGYCPPPFSHGPDLSMEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
The following text describes a protein:
Function:
mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2.
Miscellaneous:
MISCELLANEOUS: Present with 538 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGSETKHSAKVKIVTRESPPSAKEHMRPTKTQILVPPTQSLPNGKKPNFGKSTKQRREPRERTSKTGHEDDKATMVTVNIDAFLHDKAPKKKSCKYKKKKTRQYQDRAAASIDSKPHVAGHTAFAGASFTTDIPHEAALPKPSFV
The following text describes a protein:
Function:
Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Subcellular Localization:
Fimbrium.
Sequence:
MKKSVLTAFITVVCATSSVMAADDNAITDGSVTFNGKVIAPACTLVAATKDSVVTLPDVSATKLQTNGQVSGVQIDVPIELKDCDTTVTKNATFTFNGTADTTQITAFANQASSDAATNVALQMYMNDGTTAITPDTETGNILLQDGDQTLTFKVDYIATGKATSGNVNAVTNFHINYY
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MSSDTAKENASVVDSSVTEWKQDMGNSDDPESFSYKGNEGSYPSRAEKAGNSCDLLGISTTNKKGRLYNTRYFIIKSLNHHNIQLSIEKGIWATQVMNEPILEEAFHNSGKVILIYSVNMSGFFQGYAQMMSSVGWRRDNVWSQGNGKSNPWGRSFKVKWLCLNDLPFQKTLHLKNPLNDYKPVKISRDCQELSPDIGEALCELLNAKSDVDDSLSSLYRNDLPSKRLCVESPCSLGDEDYNVPQMHMSWSRTPILYPSLLYPHQVEANRIDLANQSSTGVTFSKNSPMTTGASKVERMKRSHISGDFTNLRVEMDMSPRFDSWGLSAESPHASTLTEDDFLEMSYEEYLEHTRSSKQLCLPVAGPSGKMKESSRSKKHDENMKASFSLRKVLLFSGVSPFPARQ
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in the positive regulation of brassinosteroid (BR) signaling and plant growth. Phosphorylates both BSU1 and BSL1 in vitro.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MGWIPCSGKSSGRNKTRRNGDHKLDRKSSDCSVSTSEKSRAKSSLSESKSKGSDHIVAQTFTFSELATATRNFRKECLIGEGGFGRVYKGYLASTSQTAAIKQLDHNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEYMPLGSLEDHLHDISPGKQPLDWNTRMKIAAGAAKGLEYLHDKTMPPVIYRDLKCSNILLDDDYFPKLSDFGLAKLGPVGDKSHVSTRVMGTYGYCAPEYAMTGQLTLKSDVYSFGVVLLEIITGRKAIDSSRSTGEQNLVAWARPLFKDRRKFSQMADPMLQGQYPPRGLYQALAVAAMCVQEQPNLRPLIADVVTALSYLASQKFDPLAQPVQGSLFAPGTPPRSKRV
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MGHRHVFLVSLALLVLVATTHTGGHATQAATDGVVVGVGSSSMVAGRSMVGSTPPNCEGRCGWWCVGRSCGAVLVPVEPPPHQPHNTQSRRHGSGGTGDDSTASAAAAVRQRRLSPYDDADYSNYKPVTWTCKCVGTS
The following text describes a protein:
Function:
Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MLTEVMEVWHGLVIAVVSLFLQACFLTAINYLLSRHMAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSDSLYRHDSDTPSDSLDSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPAEYDQVAM
The following text describes a protein:
Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Subcellular Localization:
Nucleus.
Domain:
The BC-box, which mediates binding to the elongin BC complex, has the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Sequence:
MPETDEEKVRRYTECLMNGIDPKRALKRLYDLNVSPEVFKSADTYQCVKRYESSPELAKYAKRVRDKLLGGRKREKGGGEDDADIEHTALKKAKKEEVNLDEEFAEAMKSGVSAQASSAPRATVDYSKYKVVKRVEVKVEPKPEPVDVHEQQASSSSMSYQREHQKDYAPVVPTCKPSGQPKKAIPQSKSLHADENMFKPRKERQKVFAGRRKRVGEGVSTLVSLCQTVLMSHIDMIDHVGIVPFDLLKPVLDHASTDQLRHILDVNPMLVEDADEMFHEMVSREFPKYANREKSGWTWREMYDRLVEKKQKKENDKLEMLTSRIGKSNSAQSQGRQTMVIDMAHTRVRSKSFFNTVKDSQVKMSATPSALQLSQARKNVKIEGKAQLRTITPRGGGVPSTSRSRSNNNNNMNNGLVVKKTAPLMAKCKKMLKR
The following text describes a protein:
Function:
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
Sequence:
MRIVVAAISFGVLGFSCRKGVKLSKRRTFRVLSNELSSYHRPFSTLLYPQKPVNMSDKKKRKATATAGDAEPSAKQPREDKPTKAAGWLHSLIRQQREDKKDMKFSKKRQRFISETQKVRQGSGGVLYWMLRDQRVQDNWALIRAQQLAAKESLPLHVCFCLVVPKSELSTLRHYSFLLKGLEEVQKECKHLNIQFHLLHGAAGDVLPGFVTGHNFGAVVTDFSPLREPLQWLEAVKKGLPEDIPFIQVDAHNIVPCWVASPKLEYSARTIRGKITNLLSEFLTDFPLVDKHPFSATKTAKAVDWDKTLASLKVDRTVGEPKWAKPGTEAGLAMLESFIDVRLKLFGTQRNDPNAAALSQLSPWLRFGQLSAQRVALQVRKNSSPSVPAFIEELVVRRELTDNFCFYNKNYDSVTGAYEWAQKTLKDHAKDKREYLYTREQFEKAQTHDKLWNAAQIQMVTEGKMHGFLRMYWAKKILEWSTSPEEALSIALYLNDRYELDGQDPNGFVGCMWSICGIHDQGWAERAVFGKIRFMNYKGCLRKFNVAQFERKYCSKKV
The following text describes a protein:
Function:
Participates in mitochondrial biogenesis and stress response.
Subcellular Localization:
Mitochondrion.
Sequence:
MRMEKTTDKPLSAGDMNDEYSRGPIDDIDCLNFFERAVQDPCCEACDTEDADEELRAKLSSFNFQPDSSPCNAKCQQTLNPLCKIDEALPAESELAPSRNGSVSEANSDTNSIASTVHDPVDSKYGGMPSLRKAKTTSYFTSSSSNNTTMRNPLKKCNTNINGLLVNGRSSSSSRQSIPELFSGACTKKKNNVLLKSETPNSEFSSNSLQHCNSRSFSLPRSRSRSSAIAIPTHLYGLEKYVSPGLDTLTADPEESIERFSNNRPREISSCCPNDTGDTSSSLSHSNTSSSLNFPLGTNTNQFHQPRQPVQQQQSSKPNFGAGRKKSFIEMSLASSFAG
The following text describes a protein:
Function:
Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Postsynaptic density. Synapse, synaptosome. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity).
Sequence:
MTSLKRSQTERPVTADRASVVSTDGAPKVHTDDFYMRRFRSQNGSLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIETSSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTSGDSFFDLLKGYKDDRSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESALSSHCTNAGVAVLEVPKESLMLHLDRVKRYTVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRAHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAKDYNKAMEFDCLLGISSEFIVLIEQETKSVAFNCSCRDVIGWTSSDTSLKIFYERGECVSVESFISGEDIKEIVRRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYQMNEGISYEFKFPFRNNNKWQRNASKGAHSPQVPSQLQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDISGSGKSTPSWQRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGPSHGSTASLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKAESSLSLDIHSKSQGGSSPLSRENSTFSINDAASHTSTMSSRHSASPVVFSSARSSPKEELHPTASSQLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLQASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHALSSPQSPFPTTPTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPIPDPGLMPLPDAASDLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSKDPSPTLASKVDQLEGMLKMLREDLKKEKEDKAQLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS
The following text describes a protein:
Function:
Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQLDTSTWFTTILSTSFSIIHRLQLKLTTHIFSPNPTPKDLKTLKHHNPWDKKWTKSYLPLSLHQH
The following text describes a protein:
Function:
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPKRGCPFADAAPLQLKVRVGQREVSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGIVSIACSSCVRAVDGKAVCSQCERALCGRCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET
The following text describes a protein:
Function:
Enhances the high-affinity desensitization of human P2RX3 purinoceptors. At 50 nM, the toxin decreases the IC(50) for ambient ATP from 2.67 nM to 0.77 nM in human P2RX3.
Miscellaneous:
MISCELLANEOUS: Negative results: does not affect mouse P2RX2 or P2RX2/P2RX3 purinoceptors. The toxin (and its derivatives composed of N-terminal or C-terminal domains) are inactive against a number of bacterial strains.
Subcellular Localization:
Secreted.
Domain:
The toxin is composed of 2 domains: a highly rigid N-terminal inhibitor cystine knot (knottin) domain and a rather flexible C-terminal linear cationic cytotoxin domain that forms amphiphilic alpha-helices; The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
AKACTPLLHDCSHDRHSCCRGDMFKYVCDCFYPEGEDKTEVCSCQQPKSHKIAEKIIDKAKTTL
The following text describes a protein:
Function:
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MSFLTYGSQILFHYLEPGPLGRKEMVVFNMCAGAMMWCYFRTCHVDPGEKGWVDRVMIDGVEKENLGKVVREGQGEEIEEKNVRWCKKCDAVKPPRAHHCKRCKRCIPKMDHHCPWTNNCVSHTTFPHFVRFLFYSVVSIIVLSTFLFTRLSYVISESTLPSYLGPSTTSLTMLFIIFCSNGLSLFAMSLLLMRTIYSLATNTYMIEAWEIERHDAIIERSKTRNMRGYVYANGGRKVRVEKVEFPFDIGIWENIVQAMGTANILMWFNPFAGGPSVQSAGKWEENGFNDKEGMWPPPDPDKLGRRAGCHGVETYPLEEKVYGSVEEERDAFRKRQEADLKRWKKDHLNTASNGGDGFYEEDDDEDEDEDEDEKYVSEYEEGLDGKEGWTNSEGDRLRDYGVDEEVDIMDEDDIPLGELLRRRKARNFESA