lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCFNLPLPHLPPYLPFITSSFFFFSFFPFSLTNTDAPIEFETTIIDPAEQTSHHVSESRPTHLSFSSSSESPRDQSREQSSRDVSASPVFPKRQQSLLRLDEHMAGGAGESRDEPHGEPSDDAHKSRASSTSSSSSFGQSWNQSSASQRASVSSMGGVDVAQKRPGPSSGGLTGASAASGMPPAPTSQAPAIPPITPQMQTGAFEQYTPQTAPPIPTQSQLGQDGRKRAATLDRQQQYVPSYGYSSPANGERGGPTGGTPGGTPMSPGGVAHVTSPGGGPSAASVHRSFSTTTPHAPTKNSRRIVSTSAAPMRKQIDDANAALGRAVDPSRDSQPMQSRDKRSKSISSRGGMKGVFSNLVSSMGTLSRKNTTVRRSESDTSAPSTPKISGPYDAKHVTHVGFNFDTGEFTGLPKPWQKLLSESGISKVEAEQHPQAVMDIMAFYTDQKDDGVWQKFGGANQAGSGATATTPYNAQNGFSPIASPGATTPTLGALNLGTPLSVDLDTEGDTSTSTGGGGGVGGGDYFAKPRSAPFPPAAGGGSASSSTATLGTGATASGGATTATPAIPSRDRTRESSLSSGTSNQGPPVTPLALSQSRQNLREEAPATPEEKPLAHFVASRKAPRPPSASPKKTGGAGASGDSGAGAAPPSAAPKSPPPRPPPAPPLGVPSVHAPNSEYRQKMITQLEAFNAKRQQERAERHAQKQKLAAAHAQAVQRQQRQQQQQQQQQQQQQSAQQGAMPSVMPQMQHGSMQQAQQSVSGGSSGLTPQQKQLIQQKQLLELQKATGGQVGGPVTSSTQQVLSNPAAAAAASQRKREQRLRKDQQVVARLNQICTPGDPTKLYRNLVKIGQGASGGVFTAYEVGSNLSVAIKQMNLEHQPKKELIINEILVMKDSKHKNIVNFIDSYLHGGDLWVVMEYMEGGSLTDVVTYNMMTESQIGAVCRETLLGLQHLHSKGVIHRDIKSDNVLLSMRGEIKLTDFGFCAQINESNLKRTTMVGTPYWMAPEVVSRKEYGSKVDIWSLGIMSIEMIEGEPPYLNESPLRALYLIATNGTPQLKEPDALSTIFKAFLAWALQVSADQRASASELLKHEFLLTADDVSTLAPLVKAARMAKIQEKNEKAQR
The following text describes a protein:
Function:
Binds to the CRE motif 5'-TGACGTCA-3' and acts as a repressor of transcription of the SUC2 gene and most probably other genes.
Miscellaneous:
MISCELLANEOUS: Present with 504 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSSEERSRQPSTVSTFDLEPNPFEQSFASSKKALSLPGTISHPSLPKELSRNNSTSTITQHSQRSTHSLNSIPEENGNSTVTDNSNHNDVKKDSPSFLPGQQRPTIISPPILTPGGSKRLPPLLLSPSILYQANSTTNPSQNSHSVSVSNSNPSAIGVSSTSGSLYPNSSSPSGTSLIRQPRNSNVTTSNSGNGFPTNDSQMPGFLLNLSKSGLTPNESNIRTGLTPGILTQSYNYPVLPSINKNTITGSKNVNKSVTVNGSIENHPHVNIMHPTVNGTPLTPGLSSLLNLPSTGVLANPVFKSTPTTNTTDGTVNNSISNSNFSPNTSTKAAVKMDNPAEFNAIEHSAHNHKENENLTTQIENNDQFNNKTRKRKRRMSSTSSTSKASRKNSISRKNSAVTTAPAQKDDVENNKISNNVTLDENEEQERKRKEFLERNRVAASKFRKRKKEYIKKIENDLQFYESEYDDLTQVIGKLCGIIPSSSSNSQFNVNVSTPSSSSPPSTSLIALLESSISRSDYSSAMSVLSNMKQLICETNFYRRGGKNPRDDMDGQEDSFNKDTNVVKSENAGYPSVNSRPIILDKKYSLNSGANISKSNTTTNNVGNSAQNIINSCYSVTNPLVINANSDTHDTNKHDVLSTLPHNN
The following text describes a protein:
Function:
May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation.
Subcellular Localization:
Nucleus.
Sequence:
MAELKSLSGDSYLALSHSYTATGHAYAAARGPETTRGFGASGPGGDLPAAPASRVPAATVESSGEQSGDEDEAFERRRRRRGSGVAVDARRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQGLAAPVAAAPLTPFGQAAIYPFSAGTALGPCPDKCATFSGSPSALCKHCGEKP
The following text describes a protein:
Function:
Catalyzes AdoMet-dependent formation of m5C in tRNA. In the presence of protein archease, specifically methylates the cytosine at position 49 (m5C49) of tRNA. In the absence of archease, catalyzes the formation of m5C at many locations in tRNAs or rRNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MDYKEEFKKINKKLVERYSKLDDSEEFWAYLYKPLRPSIRINTLKGNLKEIKALLEEKFELEPIPWTKGEGFYIKSYDVNYGQLIEYSLGLIIPQEASSMIPPVVLDPKPSEVILDMAAAPGSKTTQMAQYMENEGCIIANDAKRDRANILIANLTRAGVLIAKVTVKDGAYFARYENTFDRVLLDAPCSSVGMIRKNFKFARTWSIGKVYYHSRLQKRLILAAYKSLKPGGVLVYSTCTVDPLENEEVVDFLLQKTDAKLEKVKLPLKTSEPVIEWEGRKYSDEVRKTIRIHPQDNDTEAFYIAKIRKPR
The following text describes a protein:
Function:
Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).
Subcellular Localization:
Cytoplasm.
Sequence:
MATIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPDEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVNRLSFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHEATRYYQLSLRGCRLSLQVDGKPPPPVIANAEDGPPYYRLAEEEETAGLGGVTGSGSFFREDKAPGMQRAIDQLDDLSLQEARRGLWSDTRADMVSDMLAPLKVATTSHRVPDSGPEPILAFYGSRLTGRHKARKAPAGSKSDSNFSNLIRLSQASPEDAGSCRGSGWEEGEGHTTSTEPSAIPQREGDGPSIKDRPMDAERSGPELFDPSGCPGEWLNEPEWTLEGIRGSRAQGLPARHPHPHGPPRTTSFLQHVGGHH
The following text describes a protein:
Function:
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MRPDRKKEKMVCYNTVPPPDALSSRNGTAMSVGGVPSSSVSVKHEKPSYNMCPPPPNLYRSSLPSVSFDKVKGLVHGTGNPSDVEKKSRRRPGRKSRQVADSSSYTSTSASEASLAPGKGDGNVPIGQLSQELSKLAVSSSHMPSSSPNPVSMPSPSFRVKPVHDMSSSVYSKSNGTAESSNGDAVYHDLIPTKSTQSEDRSSFASRSAAVSTSLVSDTTAAVDSGGFSKPKTPPIGIPRARGKDGSKNGKIQGGPCMKRSASLVDSKQPAHKGWRMSPSSVTTSSSTGSLEAQHVSANSAQSVDKSGSAPSSGSNSDGGLLQNPHSWPGSSVLGSPGRTVHMPSGKVSNGASNGTSNGQSTSRSSHFSDHLSCEDAAHAIETGRAFRGVLRVNPHYRSEAYVTLEGVPLDILIDGLCAQNRGMEGDVVAVQLNPSSLWPRLKGSNKQQNSSSVVEESSVKAGAQTDDQQTRENPIFLEEHVSGVCDDITSSSATGVFEGNGWDASVQSSPEDVVDPSAWTSHLISLQDFRSSGTSKASESKESFQASASSVEMNGKQNKSSKVQVLPRAEIVAGPENSCGGAQICASLMSIAAMVSSMPSKRPTGRVVAILGKSMRREAVIGFLEVQGHNSGARASVPGSDGTSQKSGRKVSARSTGSILTFVPVDNRFPKMIIFGSGIPEHLSKRQKEGDPTLSSELVVTRVEEWKADSALPRASIKQSLGPGGTIEAQTAAILFENAIHSADFPQSCLACLPEVPWSIPEQEVRKRKDLRGLRVFTIDPPTAKDLDDALSVEQLGDGVLRIGVHIADVSFFVRPDTALDKEAQNRSTSVYLIQRVLPMLPPLLCEELCSLNPGVDRLAFSVMWSMDSSGNVLDQWIGRTIICSCAKLTYGHAQEMIDNSLSSSDGGIGGPGFSGFEGSAPLLYGEHSWADVVEDVRTLHEIAKRRRESRFDGGALKLENSKLVFFLDDDGEPCDSMMYQHQDSNFLVEEFMLLANMTVARVISGAFPERALLRRHPEPSVRKLKEFEDFCNKNGFQLDTSSSGALHLSLESMRESFHDDPVLFNILMLYATKPMQLAKYFCTGELKGKEDDWGHYALAVPLYTHFTSPIRRYPDLVVHRTLAAALEAEKVLARDGVFHGKAENQLGNADGASLRCFTGPKVDRNMTDSDAVQEALVVAAERHKIPEVAELSLVAAHCNERRMACRNVKEASDKLYLWSMVKKKQGVLSNARVLALGPKFMSLYVCKIGMERRIYYDEIEGLNAEWFEATGTLVLNLCSEKVPYRKPGPARGRPHRTVADVALLVNPTDSISSNSEQESYEDLIREVEDRLAGKIITEEDEYATTEKEDSGSEVEVEPAVLPLTLRWFSSVPVSIHAIGGESRPLDIAVRLYVSSYAT
The following text describes a protein:
Function:
Adenylates FMN to FAD.
Sequence:
MDELERVYQSIKNIFTHSAPSEKLVGLQNRLSISLRFIEYAFETYQPERLAMSFNGGKDCLVLFLLCIYYLKEKYKEQAQAKLSNIPFVFVRPRDEFPEMDDFVNECQSKYRLNIIKISLPMKEAFCKFLKEHKHIQAILIGIRRLDPHGLHRIAFEVTDKGWPKFMRIQPILDWSYTEIWDLLLETNTKYCSLYDRGYTSLGGVSDTSPNPALKNPDGTYSPAYLLSDGSLERAGRNNTVPFSRTNSRFLYDSGASSYASSEVS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MGLERDGILSQDLHFNEVFVSLWQNKLTRYEIARVISARALQLAMGAPALIDINNISSTDVISIAEEEFKRGVLPITIRRRLPNGKIILLSLRKS
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MQNFDSVMAMAAATQQQSQQQQQTADQQQQTATPNGWFDLTIKSEPLDYHPHHHHPLQQHHHHHLHHHRPGGVQQDTTTHLASDSHSNPTSPQSVDSMDSLSGKSGFFEAKGANSLMSGGYNPLGFNPLTPPGYSGLLIPPPPAQLAAQQQQQHQQHQQRLATPNRMYGNGTGKVELPTSLTPTHTPPMDVTPPKSPKESLETPTKEEDAGSDCEDGSYDGSEDEDGIRKPKVNSHGQVKKFRCKQCEFVAVTKLSFWEHTRSHIKPEKMLTCPKCPFVTEYKHHLEYHLRNHQRSKPFQCPKCSYSCVNKSMLNSHMKSHSNVFQYRCADCNYATKYCHSLKLHLRKYAHKPDVVLNLDGTPNPLPIIDVYGTRRGPKAKPQKNADKHLLKQEQAQQEQQSQPLKQQELTNSGDQSPAPLTPLSQQGMATAPTTPFTPPGSGQTNGLMRNLFPHQLFPNPLAHMFKSAAANGSLPLFPYLNLNFQMFADQQAGLQQQQQQLSPRTFQQNLMNQLAGEKLNGSATSSGSDQDNDLSVRTSSSGSTLGEELLKHITAAAADSSAAVGRNALSQEDSESETTQATPLQASFDEFPASVSSNPRTPSTTGKGERSRRKGRAFKLERLTEPATSSGGSNEMDTHYEHAEEAAVSTPVTVAVTRESPAPPKERSLECKYCDIAFRDDVLYTIHMGYHGYDDVFKCNMCGEKSDDRIGFFLHIARKAH
The following text describes a protein:
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex.
Sequence:
MKPKCDQNNSSIIENLQTSPKGQLVYDHDWHTNPQRMKDILTKASQVSDTFVHFKRCNQGLHSTNDINSHDMDIDKQNNIKSYNKSYGLLPEYLVSGEEDDDDDEGLSREENLIDAKLIEFATWMTKMKEMKRSLYERSKIAVELKRKDRLQREMLANNRAQQLEELRNQQIKSRQLQQSHQQEEHVKMLESVASKGLEFSEYIEKQKRKLLEHMRTTVYQIVQIEEKINQIFNTYEKSKILHHLPKSTEDITSILKNLHLAAEQALTQADSNSRSIDERSVATVQNCLSKAKVLQQLIEKASNIIESEIKQTKAKELEAEKILVAKQKEAAAADQTNEKLPKNLAAGSHSIFQNEDGKNETTKAKTSSSGNIYVPKFISKNAWKEYIAIMQSHKEYEQTFSNLVNDSKAKKYRFDLLIAITTPINTIASQSAEHLLDKIRRLHNLLSGKQVTCKGKVVTSTAHPEGPLFCRDIMASKFIKQADQQISASHASAFPIALTALGVWCEYPEMGNLFLAHFYSLCPYTVPFNIPRLADQNDIEYFKYDYICTNLAARKLGYHVKDGNIEDEDQYLKRMSGIIRLYAAIIQSTPPQGPTHAHPHGIEYGWRWLARIVNMPPVPNVTATLIFDFLQVAGNKLNLTYGKQFGKLITLICKEYYPKLEAVTPKSKRGPLSRLLLFLQDCLKNRHIPKAEGHIDKSFWK
The following text describes a protein:
Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular Localization:
Secreted.
Sequence:
MVSTLLLSLLLLIPAAAGTEWIDGQCPACGVPGSDPERQREILLNLAKQNILDKLHLTQRPTLIQPVSKATLRTALRRLHGLQGGRIVPGSTLGGSGTGVEEQEYEIISFAETGYSTTNRTVLDFQLSPDQSSGSLEVLQARLGFFLKIPPNGTWTMHVRVLGPGPRDTNLTLTTQHQLEVDASGWHQFLLGPEAQAAYGQGHLTLELEAKGWGAQGPVFLEKDAHQPFIVAQVRIGEKHRIHRRGIECQGGSQMCCRQEFFVDFREIGWNDWIIQPEGYAMNFCTGQCPLHVAGMPGIAASFHTAVLNLLKANGAPGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS
The following text describes a protein:
Function:
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKLIPILEKIPEVELPVKEITFKEKLKWTGIVLVLYFIMGCIDVYTAGAQIPAIFEFWQTITASRIGTLITLGIGPIVTAGIIMQLLVGSGIIQMDLSIPENRALFQGCQKLLSIIMCFVEAVLFVGAGAFGILTPLLAFLVIIQIAFGSIILIYLDEIVSKYGIGSGIGLFIAAGVSQTIFVGALGPEGYLWKFLNSLIQGVPNIEYIAPIIGTIIVFLMVVYAECMRVEIPLAHGRIKGAVGKYPIKFVYVSNIPVILAAALFANIQLWGLALYRMGIPILGHYEGGRAVDGIAYYLSTPYGLSSVISDPIHAIVYMIAMIITCVMFGIFWVETTGLDPKSMAKRIGSLGMAIKGFRKSEKAIEHRLKRYIPPLTVMSSAFVGFLATIANFIGALGGGTGVLLTVSIVYRMYEQLLREKVSELHPAIAKLLNK
The following text describes a protein:
Function:
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MRREAAGGPLQSLRPRAGPGPLPGGVSCPALPPRPLPAPSPGRSLYGLGAALSPPPPSLPLRVVPPRLARSCSGPGRRVRGLGAEAVIRDAALTLLPAPGLTMAAPRPPPAISVSVSAPAFYAPQKKFAPVVAPKPKVNPFRPGDSESPVAAGAQRAQMGRVGEIPPPPPEDFPLPPPPVIGEGDDSEGALGGAFPPPPPPLIEEPFPPAPLEEDIFPSPPPPLEEEGGPEAPTQLPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFVPKPSTKPAPVGTAPLPPWKAPSSSQPPPQPQAKPQVQLHAQPQAKPHVQPQSVSSANTQPRGPLSQAPTPAPKFAPVAPKFTPVASKFSPGAPSGPGPQPSQKSVPLEAPSSVGTGSPQPPSFTYAQQKEKPLVQEKQHPLPPPAQNQNQVRSPGGPGPLTLKEVEELEQLTQQLMQDMEHPQRQSVAVNESCGKCSQPLARAQPAVRALGQLFHITCFTCHQCQQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGQPITDRMLRATGKAYHPHCFTCVVCACPLEGTSFIVDQANQPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKALSIEADDNGCFPLDGHVLCRKCHSARAQT
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Sequence:
MRPRITFRPLHGILLLDKPAGLSSNNALQAARRLLRAEKGGHTGSLDPLATGLLPLCFGEATKIAGLLLGSAKAYDAEIVLGVTTDTDDADGQPLRERSVPALSEAALQAALAPFIGRIQQQAPIYSALKQGGEPLYAKARRGEVIEAPVREVEVHAITLTSYASPRLRLRVTCGSGTYIRSLARDLGEVLGCGAHIAALRRVWVEPFRTPEMITLEALTALVESGADAAQLLLPVAAGLSDFAQITLDATLAARFRMGQRLRDPAFPEGQVAVFDADGSPAGLGLVDADGRLSPQRLFNGLNAAAAC
The following text describes a protein:
Function:
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.
Subcellular Localization:
Nucleus.
Sequence:
MSYFGLETFNENQSEENLDEESVILTLVPFKEEEEPNTDYATQSNVSSSTLDHTPPARSLVRHAGIKHPTRTIPSTCPPPSLPPIRDVSRNTLREWCRYHNLSTDGKKVEVYLRLRRHSYSKQECYIPNTSREARMKQGPKKSKIVFRGIGPPSGCQRKKEESGVLEILTSPKESTFAAWARIAMRAAQSMSKNRCPLPSNVEAFLPQATGSRWCVVHGRQLPADKKGWVRLQFLAGQTWVPDTPQRMNFLFLLPACIIPEPGVEDNLLCPECVHSNKKILRNFKIRSRAKKNALPPNMPP
The following text describes a protein:
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Domain:
The PAL motif is required for normal active site conformation.
Sequence:
MEKGILDVVGGEIVGIVTPVSICMFLVVTLVHILDPRGEDAPVSNIAMMVYNEQASDSFSEKLGGALLNAIVFVVIVTLVTFMLVALFYYRCTRCLRVYMGISAFTVLAWMGGIVAVQIIKLYSIPIDVITFLICTINFASVGVAAVFFCRMPIMVTQGYLIVIGMLVAFWFTKLPEWTTWVLLLAMAAYDVVAVLTPRGPLNLLVELAIERDEDIPALIYEARPTVSGRMQMPPSPAQMGSDAERPRVRRWNRRASRSSNPSPDTELGESPMSSGNASQRDSTLTAAVDDSQNLITGPPTEPEVGIIGSRLISSTGEGGALHAVSIILHENSHMDDDTVPLVQQQTNSPSSPATLGRSEAEFDHRSRPMNGATQHSEDGDEETGIGLSGAIKLGLGDFVFYSVLVGRAAMYDLMTVYACYLAIVAGLGATLILLAVWQRALPALPISISLGVIFYFLARLVMDPFVLDMSTNLVFF
The following text describes a protein:
Function:
Has antiviral activities.
Subcellular Localization:
Secreted.
Sequence:
FATQDPWLTAIPLATHRLRLQPPSPQDATFSHDSLQLLRDMAPTLPQLCPQHNASCSFNDTILDTSNTRQADKTTHDILQHLFKILSSPSTPAHWNDSQRQSLLNRIHRYTQHLEQCLDSSDTRSRTRWPRNLHLTIKKHFSCLHTFLQDNDYSACAWETRPPATRALSPKRTSHPLSYLSIYSTIYTNAYLFFYLFFYLFRQNKALLFNLA
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MDIFKVLSRGIKAQPKKNQPGAPQLLPSAGAKVNPQFFHDNVGGANAKRGKKRKRKGAQANNATESGDEDDDASDVDYFAPKPTPEELAAKKDAELKADEPKKQKPKLLEENECRQILKSHRLKFTVLAGRVPQDEAATEEKPPKKQKKQKEDRKKQEEEEKKKKKKDEDKKQIYPQPLNSFGELKYTYGIHPVLADNITRQGFRVPTEVQMGSLPLQLRPEMALEKATDVEDVKVEKGIDFLGVAPTGSGKTISFLIPAIDAIIKRRAEDYTPETDEHVLQAIVVAPTRELASQIVNEGRKLAIGTGVRVVLMKRTLRLVAESNEQEETEQEAKEEVQDSDSDSEAESEPEEVMKIDEEEEEEEESDSDAEKKTESRAKGDQKFKKERPITRVDILVTTPKILLNFLCGGEKEKGKPRIIKKTLPTVQSLILDEADVLLDPIFRKQTMGIWRACTHPNLGMTCWSATMASNIEALLTKHIDKRAKRTPEQTPKPLIRLVVGLKDTAVPNITHKLIYTATEPGKLLALRQLLHPVSSADSGPPLRPPFLVFTQTIERAQALHDELKYDIPLEAGGSARVAVLHSSLPDSVRSKIMARFRSGEVWVLITTDVLARGVDFAGVNGVVNYDVPVSAAAYVHRAGRTGRAGREGGVAVTFYTKDDIPFVKSVANVIAMSEKQAGKDIDEKDTVKAAQGSVQKWLLDALPKVAKEDKRKLKVRGVESRRTGGKATITTKSSWERRRENNRREAIEASKRRKREAQKAQKEGGAAPEKAEEEWTGLD
The following text describes a protein:
Function:
Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.
Miscellaneous:
MISCELLANEOUS: Present with 11300 molecules/cell in log phase SD medium; MISCELLANEOUS: In contrast to metazoans, where the CBC complex is involved in the nuclear export of capped U snRNAs, it is believed that in yeast, U snRNAs are not exported from the nucleus and U snRNPs are assembled in the nucleus from RNAs and imported proteins.
Subcellular Localization:
Nucleus. Cytoplasm, perinuclear region. Note=Predominantly nuclear, is able to exit the nucleus in an RNA-dependent manner.
Sequence:
MFNRKRRGDFDEDENYRDFRPRMPKRQRIPPVVQLCKEMMPDIRTIGESVKAFEDDIKFLSEAIMNEYGHEDYFNNALLSTLNAVVVEQPQKQAAIALLTMVVNSKNNVAGKSIINYFFEELQKWCKQTYNDEFKSTSNETGPWNKIKLILRFLSILSPMFLVDELINIYKSLFELSIELNNLDPGNRVPLSEAIYTNTLLNIPYLFFFNRNNDGLRTKVEELLAYVEQNYLVKTTDINLLREYNGEPPYEMVELVRVVLPNVKKALINNLEQLNELFPDWNHLLTPQTGDEGFNDALTLPSVDDLKSFVRLNKNFGSVDSMWKTPRYAFHVYLPNSAGNFETVVPISTYAGQLFNDIIIDLVESLEFNRKEVARQVITLDLFFKAGIFTEPGESIAQLIATYEENPLAPTFKIEDLAIETILGLIFKLPSVSQPFAYFYTLLVDICQNSPKAIAPVFGRAFRFFYSHLDSLDFELKLRYLDWFSIQMSNFNFSWKWNEWEDDSIKFGKYFYNPKVNFAKNLIQKELRLTSNFSEVEDSLPQEFTKYLDTSYIPRDQLINYYQSLFTGYTVEEDSVRKNDLYFRQEGVPMENTVRKILDYTHKANNSREVTELESILGELKNEYGSIISDFNRFVIILLVQAVTDSGSRSLSHANKYINDLKEDLKTIFAKIELDIETKEYIIIEAVLTFWNANPQTGFLVADAFKYAGLLTSRTIFTFIFNETGLKNNGLIEATAIEAVFRNLSQQISEENESGNNFEFVFERLCTIANSTIDLLDVNADEDIEIPKVNGEMDIDDIEDDKLDLKWKYFTVIGFIKSILRRYSHEYRELADKFIANIDNAIPHESTRRTISNWIQETKEV
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MIVFISLFTLFLTLLSILTNNVIVWWSIFLLMTVVFILLNKSSKSYTSIFNYFVIQESLGLLFLLCSGGLLQFFIILLKIGVAPLHFWIFNVTNNIFNYGLMWFLTFQKLPFLTILLQIFWLSSVYILLFGLLICYVQIFVMKSYKNLLIISSTESFNWIVLGVFFSMFNTFYLFIYYFVLMVLLISKFSKTSGYNFINWETTLVFLNIPFSVSFFVKIFSLSEIFKYDSFFTLFLLFTMFLSVLAFSFWLINLSMKNNEETSNNNKMNYFIIFPLMVISII
The following text describes a protein:
Function:
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
Sequence:
MKKWEHYEHTADIGIRGYGDSLEEAFEAVAIALFDVMVNVNKVEKKEVREIEVEAEDLEALLYSFLEELLVIHDIEGLVFRDFEVKIERVNGKYRLRAKAYGEKLDLKKHEPKEEVKAITYHDMKIERLPNGKWMAQLVPDI
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs.
Sequence:
METPLDVLSRAASMVETDNGKNEEERDKSTLQNGNCASRPPPSPQHSPVLKEQPSKVERHRRSTERRELSHVLGMDDEQRAKVATMKCAGTQTHLTSVKETANLTDEALETINNMEASDRERLLMSMASKPMLIPMSSIHSPLPHPPQRPSVITCAPAFSRVSPPPAGNGVSTTVQGAARREIITTGVVDPVIEEHFRRSLGKDYKVEEPPVEPPRAASTPPDPNNVSITGSVDDHFAKALGDTWTKIKARKESVSSNKSTPPPSPHLPASHSNQPLLST
The following text describes a protein:
Function:
Functions as a receptor binding protein (RBP) and probably mediates the attachment to the host capsular exopolysaccharides. Displays a depolymerase activity that specifically degrades the K2-type polysaccharides of Klebsiella pneumoniae capsule, which allows the phage to reach the host cell membrane and bind the entry receptor.
Subcellular Localization:
Virion. Note=Tail appendage.
Domain:
The N-terminus contains an extended triple helical bundle. The central part is a beta-helical domain, which forms a negatively charged cavity at the interface between neighboring monomers. This cavity may contain the active site. The C-terminus is formed by 3 four-stranded beta-sandwich folds.
Sequence:
MALYREGKAAMAADGTVTGTGTKWQSSLSLIRPGATIMFLSSPIQMAVVNKVVSDTEIKAITTNGAVVASTDYAILLSDSLTVDGLAQDVAETLRYYQSQETVIADAVEFFKEFDFESLQNLANQIKADSEASESSAAAAAASESKAKTSEDNAKSSENAAKNSEVAAETTRDQIQQIIDNAGDQSTLVVLAQPDGFDSIGRVSSFAALRNLKPKKSGQHVLLTSYYDGWAAENKMPTGGGEFISSIGTATDDGGYIAAGPGYYWTRVVNNNSFTAEDFGCKTTATPPPNFNVLPAELFDNTAMMQAAFNLAISKSFKLNLSTGTYYFESSDTLRITGPIHIEGRPGTVFYHNPSNKANPKTDAFMNISGCSMGRISSINCFSNSYLGKGINFDRSVGDNRKLVLEHVYVDTFRWGFYVGEPECINQIEFHSCRAQSNYFQGIFIESFKEGQQYGHSAPVHFFNTICNGNGPTSFALGATYKTTKNEYIKVMDSVNDVGCQAYFQGLSNVQYIGGQLSGHGSPRNTSLATITQCNSFIIYGTDLEDINGFTTDGTAITTDNIDTIESNYLKDISGAAIVVSSCLGFKIDSPHIFKINTLSTIKLMNNTYNYEIGGFTPDEALKYNVWDANGLATNRISGVIHPRLVNSQLGINSVAFDNMSNKLDVSSLIHNETSQIIGLIPSTGSNVPHTRIMWSNGAMYSSTDLNNGFRLNYLSNHNEPLTPMHLYNEFSVSEFGGSVTESNALDEIKYIFIQTTYANSGDGRFIIQALDASGSVLSSNWYSPQSFNSTFPISGFVRFDVPTGAKKIRYGFVNSANYTGSLRSHFMSGFAYNKRFFLKIYAVYNDLGRYGQFEPPYSVAIDRFRVGDNTTQMPSIPASSATDVAGVNEVINSLLASLKANGFMSS
The following text describes a protein:
Function:
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSFTVAQRQRAIGLYKRLLRTSRKTFEGDSVAISAARDETRRRFKAAAQETDASKIDEGLKMGDEIISVLRQNVVQGKWRQERDAYELRMTKDTELGNNDSIKEARAKQIADLKAGKKPERKSCREMAAQYQAAAASPSSSMATSSSSAFNTVRAFSTSTRPTTSTIAAHACGFRSQRSGFASSASNASRDPSAMAQTPLPRPVPKFSSTTILADGSSIQISTTSPRRLTRLTRDPTNHPLWNPGQERKVGGDADDDSGRLGRFRRRFDGLDGASASGKPAEANKDAREVSFGQEDLDWMSVGGREARAGSPIAAKKAGKGKGRK
The following text describes a protein:
Function:
Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.
Sequence:
MASSVLTVGEYLIERLYSHGVHHIFGVPGDYVLGFFKQLCDSPIKVINTCDEQGAGFAADAYARVRGLGAVCVTYCVGGLKVANTTAQAYAEKSPVVVISGAPGTNERHKNPLLHHKVREFDTQLKVFEQLTVAATVLDDPQTAFCEIDRVFEAALRYRRPVYIELPRNVARATGSACHLRELPQETSDPATLGEAVKEAVARINASRQPVILAGEELHRFALQPLLAQLIEKTNIPVASTILGKSVFPESHPRYLGVYEGAMGREDVRDYVEASDCLVLLGALMTDMNLGIYTANLDPRRSIYCATEKLTIGYHSYEDVRLQDFAAGLLAGEIERRVDGPTPHPLPLAQFQPVQDRPMTVLRLFQQLNAFLDDETIVVADPGDALFAGADLFIPGKTRFLAPAYYASLGFAVPAALGAQMADARLRPLVLVGDGAFQMSGLELSTIARFGLDPIVVLLNNRGYGTERPMQDGSFNDVLNWNYSRLPELLGTGRGFEVSTEDQLAAALHEARRHRGSFSLIDVHLEPGDLSPALRRMTDSMGQRVRPAAV
The following text describes a protein:
Function:
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MTFARSSRSGLQDTIAAVATAPGSAGVGIVRVSGPRALEIADGLFRGKRRPSATPGGRFLFGELHADEELLDEGLCLVFRGPRSYTGEDVAEVQTHGSPAVLSRVLARTLDLGARLARPGEFTLRAYLAGRLDLTQAEAVLGLVEASTETARRQSALGLSGALSERVAGVARALTRTLAAIQALLDYPEEGVPDEDRAAPLLGAQSALEELLASAHAGRISTRGARLALIGRPNAGKSSLLNALLGYERSIVTPLPGTTRDYLEAGLELAGVPVTLVDTAGLRETEDLIEAAGVRQAVALAGNADLVLVLEDGSQPREPLPTELPPTATVLRLRTKADLPAAWTDPAALDVSAVTGAGLPALREAIGAALLGDATRGEAWLTTERQTDTVRRALTHVQAARTLPDDLAGYELEEALHALAELTGQDVQEDVVDAVFRNFCVGK
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MDFGAGTSRCRMVGDYIIGPKIGSGSFAVVWKSKHRHLGTEFAIKEIDKKHFNDNLRKEISILRNITHPNIIRLFEAIETEERIFLVLEYCEGGDLGAYIHRHGRVSEDVARHFIKHLAAGLQVLRDNNLIHRDLKPQNLLLSGREVTPLLKIGDFGFARYLTAQGLADTLCGSPLYMAPEIIQNQKYDAKADLWSVGAICYQLVIGKPPFDGNSQLQLFQNILRSTELRFPEGALQVLHPDYVEFCRSLLRRNPVERLTFEEFFNHKFLMDPRVEVDAEFSSQISRVKSLVLTDDHGPLFDHDDKIAPKESVKRRVEVDAEFSSQISRVKSLVLTDDHGPLFDHDDKIAPEESVKRSSVNDEKREFEKDHRNTSGGRSVDGVMPDILTDKTRHSDEDGPQSLSQTRVACSLDSIEGEYVLVHSNFASMEILTSSLGTSLKKCSATKACELAPKNIDKQLPTMPEMNELAPRLVSGSDSVLQSEEQDLPILHPSTRLQLINQYVGVLSDLAQEKFNAGFFLESFSAELVVLALWKKALRICNSWLLESGLPESSSANEFGEGAASSSSQLKNTTDFTNPSSVSAWAEQGFLNAYDGTEKLSKYLQDVDGAAEMPDAMEIIFQTAIAAGKDGAADEFVGNRDSASMMYSKALMLFSFIVTEAPSLSLNPPFFLAPESKQQILKYIKSLEYHLSHSQTSVKQLPDFGIK