lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point by about 1.1 degrees at a concentration of 0.1 mg/ml, and by about 1.5 degrees at a concentration of 0.2 mg/ml. Binds to nascent ice crystals and prevents further growth.
Miscellaneous:
MISCELLANEOUS: The concentration in blood serum is about 0.2 mg/ml.
Subcellular Localization:
Secreted.
Domain:
The polypeptide has an alpha-hairpin structure. Two subunits dimerize to form a four-helix, rod-like structure. Each subunit is composed of a cap structure and of tandem 11 residue repeats with the sequence [TI]-X-X-X-A-X-X-X-A-X-X. Each repeat forms three helical turns with an average of 3.7 residues per turn, as opposed to 3.6 residues per turn for a classical alpha helix. Contrary to other proteins, where the protein core is stabilized by hydrophobic interactions and contains little water, this protein contains in its interior over 400 ordered water molecules with a semi-clathrate structure. Most likely, the interaction with the surface of ice crystals is mediated by bound water molecules that protrude between the helices.
Sequence:
MALSLFTVGQFIFLFWTISITEANIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP
The following text describes a protein:
Function:
Required for pantothenic acid biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 2400 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKIFHTVEEVVQWRTQELRETRFRETIGFVPTMGCLHSGHASLISQSVKENTYTVVSIFVNPSQFAPTEDLDNYPRTLPDDIKLLESLKVDVLFAPNAHVMYPQGIPLDIEEQKGPFVSVLGLSEKLEGKTRPNFFRGVATVVTKLFNIVMADVAYFGQKDIQQFIVLQCMVDELFVNTRLQMMPIVRNNNGLALSSRNKYLCPESLKISENLYRGLKAAENAIRRLAPGGRLSRSEIIDTVTQIWAPYVDSHDFKIDYVSLADFKTLDELSDVENTSEQQPIVISCAVYVTDREKPDTVVRLIDNIVI
The following text describes a protein:
Function:
May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.
Sequence:
MGHGGEGMSLEFTPTWVVAGVCTVIVAISLAVERLLHYFGTVLKKKKQKPLYEALQKVKEELMLLGFISLLLTVFQGLISKFCVKENVLMHMLPCSLDSRREAGASEHKNVTAKEHFQTFLPIVGTTRRLLAEHAAVQVGYCSEKGKVPLLSLEALHHLHIFIFVLAISHVTFCVLTVIFGSTRIHQWKKWEDSIADEKFDPETALRKRRVTHVHNHAFIKEHFLGIGKDSVILGWTQSFLKQFYDSVTKSDYVTLRLGFIMTHCKGNPKLNFHKYMMRALEDDFKQVVGISWYLWIFVVIFLLLNVNGWHTYFWIAFIPFALLLAVGTKLEHVIAQLAHEVAEKHVAIEGDLVVKPSDEHFWFSKPQIVLYLIHFILFQNAFEIAFFFWIWVTYGFDSCIMGQVRYIVPRLVIGVFIQVLCSYSTLPLYAIVSQMGSSFKKAIFEENVQVGLVGWAQKVKQKRDLKAAASNGDEGSSQAGPGPDSGSGSAPAAGPGAGFAGIQLSRVTRNNAGDTNNEITPDHNN
The following text describes a protein:
Function:
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function. Required for sperm cilium basal body elongation together with Cep135 and Ana2.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Component of the centrosome.
Domain:
The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
Sequence:
MWPPGSEDSYSAKMDYGKSVVNILPSVEMLVNFNGEMTRSSKRSCLLYAERVDFKELLQLRLTEKSDQRRMYITTVDSASFQDLKQDQSLNVSFSGFIDNVVRMLKDCQSGKLELHLTTRDQNLSSGREVHDYYLQFVEIRSFKNLVHLSLPCRSAPLNTVLFYINSMLEASHKKQYILEQSMQQMQAEINAQRAHAERLTTENTNIREALAENTRILEEKHAAEVHQYQEKLSKINEQRSNELERNRRAISGFQAQLDKASLEKAELKSAQEQAEKRCQTLSEELSCCKARVCTLKEQNDKLHGDVANIRKHERKLEYKIEDLKQHTVELQEHIQKGNKEKANIAAELEAEKKILHTKRQALEMASEEISKANQIIVKQSQELLNLKKTIAWRTEVALQQEKAVQAKESLLSLRENELREARITIEKLREEIPQQLQSMRNFAQGLEQKYSKQILILKERLAIPTGKENRR
The following text describes a protein:
Function:
Acts as a component of a SCF E3 ubiquitin ligase complexes.
Subcellular Localization:
Nucleus.
Sequence:
MANNEKDACSSFTDFPEDIQVCILSFLGPPEIATLACTSKRMGSLCATDSKLWFSMCERRWGSYTRITQWAQGKNPTLSFKHLYNTLHRWENLLGFWRRSGTGIPSLLFFEWGPSFISASRVSPSASDSNSVTYGVTKTPFLWMSLSEEGHVVTYLDPDGRSDFKPEIRSELVAVDVSFMGKTHLVVEEKRVRGGACHDCGDDVVVVESGSPPEKLMAEIYQHFANPRSPGSDRSRRQRRREKERLAGRKWEPQHFVKIVNCSPTPARPLQGLWKGICGDMSLAFYLVGYDDIGGIACRRIGDPPDRFSGHAPVFWTSNATFLESPFSPEEESLYDSRVHLRPLQPGNEVLEQFPFSDSEVVNQIQQFQLSDNVVDRILHISSSYDLVVPDLAGTLNPRSAEGRIWQYRNGTFGFGFLSDNFVIDMKHIVHNGCIVDTVNSSAN
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MYFHKNVDTRRRGSNVNRLATPAAVASTATDNDDNNNQNINSSEGAGKSTLSRSFGLTSEKLSGLQLKFGFVNKWDDEKYFQDLNSSKLSIWSITGSSSDGEYCDITWQLKQILTPSNLECSIVLLVEPMDQSRNMIRNFEHYVQCLVGHLSKLDVDHEITRKKFEAVYRALHSRDSNPHPSSECNCGRVSVSKYLNVPIITVVTKTDIKLDGSEMKNASGQPDSENLKKYLALSLRKFASANGSSLVCTSSRSSVNCVLLFDYISNLCFGTSYRVIPETNVLEAMFIPNGLDNVKEVSDLYSAFVASLENKSHSSADVQMEMDRRLLNKFPPHKPMQLPPLTGCDDNATYLQLLLQIMKEPLVRETNVKIKDPNELLEDCNTPTTGGRRSSMTPRRQPTTPHRNLICDSNNSVVLVTFFSSLINSPRPSLNSGPPSPAPPTRPVRDP
The following text describes a protein:
Function:
Oocyte-expressed fertilization factor that mediates sperm-egg binding and is essential for sperm entry into the egg. Necessary and sufficient to mediate species-specific gamete recognition and fertilization, which is essential for vertebrate species performing external fertilization. External fertilization cannot guarantee that only conspecific sperm reaches the egg by precopulatory mate choice: proteins such as Bouncer can therefore support the selection of conspecific sperm.
Miscellaneous:
MISCELLANEOUS: Zebrafish oocytes expressing O.latipes protein Bouncer can be fertilized by O.latipes, but not zebrafish, sperm.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MGSLRTRQLFHAALLWLCLPLPLLLCENLHCYYSPVLEKEITFELVVTECPPNEMCFKGLGRYGNYTALSARGCMLEKDCSQVHSLRLLGTVYTMSYSCCDWPYCNRAVALEPLTAMLVAAAVVACSFCLT
The following text describes a protein:
Function:
Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Binds 20(S)-hydroxycholesterol (20(S)-OHC).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MLAALLGGAGARTGTLPGALLCLMALLQLLCSAPRGSGLAHGRRLICWQALLQCQGEPDCSYAYSQYAEACAPVLAQRGGADAPGPAGAFPASAASSPRWRCPSHCISALIQLNHTRRGPALEDCDCAQDEHCRSTKRAIEPCLPRTSSVGPGAGAGSVMGCTEARRRCDRDSRCNLALSRYLAYCGKLFNGLRCTDECRAVIEDMLAVPKAALLNDCVCDGLERPICESVKENMARLCFGPDASNGPGSSGSDGGLDDYYDEEYDDEQRAGAAGGEQPLDDDDGLARPGGGAAAAGGRGDLPHGPGRRSSSSGSGGHWANRSAWTPFACLLLLLLLLLGSHL
The following text describes a protein:
Function:
Possible tumor suppressor which may play a role in cell growth.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPCACNRNNWRKWIRPLLILLYALAILVTVPVCIWEFQKLKVGIHTKVWFIAGIFLLLTIPVSMCGILQHLVHYTQPELQKPIIRILWMVPIYSLDSWVALKYPKIAIYVDTWRECYEAYVIYNFMIFLTNYLTIRFPNLMLHLEAKDQQNHLPPLCCCPPWAMGEMLLFRCKLGVLQYTVVRPITTVTSLVCEILGVYDEGNFSFSNAWTYLVILNNLSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVLIALLVKVGVISEKRTWEWQSAEAVATGLQDFIICIEMFFAAIAHHYTFSYKPYVHEAEEGPCFDSFLAMWDVSDIREDISEQVRRVGRTMRGYPKKKCFPGDPDHNEHSSLLSASSQDSSKPSSPVGLYQGFGQTITSQSPISIANLYEEILNEIPEEQQRLYSGQDITMDIPEEQPRHDTGQDVVHLPYRQELPYKNHYQDHIQTVTSRYLLSSPKPSDDIVIDFSDSPEGSDSSTDS
The following text describes a protein:
Function:
Responsible for microtubule translocation. May be important for the organization of phragmoplast-specific arrays of microtubules. Plays an essential role in stabilizing the mitotic spindle. Required during mitotic cytokinesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MESSQSQQQRRGGGLILQTPPRSSDKAAARDLRSGEGNNNMSGKHDKEKGVNVQVILRCRPLSEDEIRLHTPVVISCNEGRREVSAIQNIANKQIDRTFAFDKVFGPTSQQKDLYDSAIWPIVFEVLEGYNCTIFAYGQTGTGKTYTMEGGGRKKNGEFPSDAGVIPRAVRQIFEILEAQNAEYSMKVTFLELYNEEITDLLAPEECTKYVDDKSKKPIALMEDGKGGVLVRGLEEEIVSTANEIYKILEKGSAKRRTAETLLNKQSSRSHSIFSITIHIKECTPEGEEMIKCGKLNLVDLAGSENISRSGAREGRAREAGEINKSLLTLGRVINALVEHSGHIPYRDSKLTRLLRDSLGGKTKTCIIATISPSVHCLEETLSTLDYAHRAKNIKNKPEINQKMMKSAMIKDLYSEIDRLKQGLYFYLPLFLYINIYLALINYLITYFVCSILMPTEVYAAREKNGIYIPRDRYLQEEAEKKAMSEKIERMELDFESRDKKLLELQELYNSQQLLTAELGDKLEKTEKKLQETQHTLADLEEKHRQAITTIKEKEFLISNLLKSEKALVEQAFELRAELENAASDVSNLFAKIERKDKIEDGNKVLIQKFQSQLTQELEVLHKTVASSTTQQEQQLKGMEEDMQSFVSTKTEAVEELRGRLENLKTMFGSGIKALDGLAGELDGNAQSTFDRLNCEVSKHSSALGELFKEIASEADILVNDLQKSLHNQEEKLIAFSQQQREAHCGSITMSRSISQITGNFFKTLDMHVSQLGEIVEEAQTVSDQKFSELENKFEECAANEERQILEKVAELLAGSNARKKKLVQTAIDDLRESASNKTNRLKQEMSTMQDSTSSVKVEWSNYMEKAESHYLEDTAAVENRKKEMEEVLQNCVEKAKLGAKQWTNAQQSLLNLEERNVAFVDEIVRGGMDANQALRMRFSSGVSSTLEDTDAASKHLLSSIDHSLQLDRDACANLDSTIVPCCGELRELNSGHYHKVVEITEYTGKCLSQEYVVDEPSCSTPTKRPFNLPSVESIEELKTPAFEELLNSFWDGKSSKQANGDVKHIAEVAPLRDSRVALTALN
The following text describes a protein:
Function:
Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MNEATLPRHLSSSSASNIGYDVLYPGHIPTNTFQKFLLAFGSSAITLFNPSRGDMLALFGETSGACALQRMKKRMEQDEEGRLILREKPVINTGTVDLNKLKELSDGTFGRVYHDWLKPNQAHPDERLPVQFVDDAELAYVMQRYREIHDITHVILGMNTNMIGEVTVKLFEGIQTGLPMCVTGGIFGTWRLGPKHMKLYFDTHFKYAIKQGFNAKSFMNVYFEKYWEMNIDELRSLLNVDKPPYTPKKKNIYYQKSN
The following text describes a protein:
Function:
Essential for the first active step of germ cell migration: transepithelial migration of germ cells through the posterior midgut (PMG) epithelium.
Miscellaneous:
MISCELLANEOUS: Overexpression of the Tre1 gene restores the taste sensitivity to trehalose in a Tre1 mutant. This experiment cannot be explained given that other authors demonstrate that trehalose sensitivity maps to the adjacent gene, Gr5a.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDQDMGMATGYFQDADMQMDEPAAATQSIYPHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREHATTAFVISLSISDLLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQIYKPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRSIKKTLFVIGFLLPCLVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSSSSGGGSYMTTTCTRKAREDNRLTVMMVTIFLCFLVCFLPLMLANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNYRVAYYKIFALLKFWGEPLSPMPSRNYHQSKNSKELSGVIRSTPLFHAVQKNSINQMCQTYSV
The following text describes a protein:
Function:
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.
Sequence:
MVFIMLRSILIITGCLAITVLIGIFLLYYTGTFGPHFSLVKTSFNSLPEWKQDNQSQALIAFQKSCAEILKRNPHESFNGLSQAGLVQNWQVICNAANKVERQNPQMARNFFEHWFTPYSIKNNFNPRGLFTGYYLPLLHGSLKKEKPYIFPVYGLPKDLIKIDLGLFRPELAGRSIVAQLKKRNALLPYPDRAAINQGAIQSSAPVLVWCDSVIDLFFAEIQGSAIVKLPNKKQLLINYAGDNGHPYTPIGKILVERHIMTKEEASLQGVRKWLLDHPTEVNALLNCNASFVFFKLINNSGPLGTEKIVLTPERSLAVDKRYIPLGAPIWINTTSPTNHSQEKATPYRHLLIAQDTGGGIKGVVRGDIYWGAGDKAEFIAGHMHNVGKYWVLLPKMPQSEQLN
The following text describes a protein:
Function:
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
Miscellaneous:
MISCELLANEOUS: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKWKRANPNGTRDYLFEECTLIEEVEQKLRLTFLERGYEEIRTPTIEFYDVFAFQNRPIDEEKMYKFFDEKGRIIVLRPDMTIPLARVIGTQRWDTPLKVTYSGNVFRANESHSGKYNEIVQSGIEVIGIDNVRAEIECVISVIQALQKLKVQSFTIEIGQVQLYKCIVKKLSIQDEEERVLRTYIESKNYAALSNFIGEKKLDRCDETVRLLEKLPRLFGNLEVIEEAEKLASSNEMKMAIARVKEMYETIEMLGYGSYISIDLGMIQHLDYYTGVIFKGYIYEIGEEIVSGGRYDELIGNFGEMLPAVGLAVQVNQIVKALQEQQEPYERNQIDIVIHYELNRLAEAERLRNLLRKDGKNAWLSLFSNLSDTFQFARKNKIGTVVEAQNEYLVEYVWNEKWVVQKEGEASCVTFKLR
The following text describes a protein:
Function:
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition.
Subcellular Localization:
Nucleus.
Sequence:
MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLKNRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRLELDALRGKCEALQGFARSVAAARGPATLVAPASVITIVKSTPGSGSGPAHGPDPAHGPASCS
The following text describes a protein:
Function:
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
Subcellular Localization:
Cytoplasm. Nucleus. Preautophagosomal structure.
Sequence:
MSLQRALQYLWDAEPHNTDHVTPLFCLGQVYDADTSLKEVNDDTEEDGIVVPLDTSNDTSWPPDFLADVQSRIWLSYRTGFPLIPKSDGSGTIHLGKLKNMIRGGGFDPRGYTSDVGWGCMIRTSQSLLANALLFRHLGRGWRWNKGDDFVYLSEGNTESRGGESRNGGANKEQETAVSEETAVSEETIISWFLDSPDSPFSIHKFVRHGEKACSTPAGDWFGPSAAGSSIYALCNEFPDSGLKVYYNGNGGGDVYEDELLETGFPLLVLCGLRLGIDNVNPIYWDSLRQMLSLPQSVGIAGGRPFTSHYFFGFQGEQLFYLDPHQPKPAVKTTDKDTTSFHSSRIWKLHLKEMDPSMLVGFYITSEADWETFKGSLTASKEKTSSQIVHIHPSRHNIPSFDEEDEYVSIGGASDDDFVDVTKRARKVAAMTGNTGSGRSSPSILDSHLVTETRDIIESVPPRKRVDNDLTSAPVDVPKPVQKRSQSHGDWEKVEEPEEEMVEVESMKGMQDNGCSAEYGSLVDRDAEADDSTLSTETTDRDWVV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MEYQRAIDSIEECLNKQLRLSSEKVDQYVLIENWTSLVGHLKTLHSLISNYTNGRELQNEISSLLKQDKELDLQIQDCMREMTSIYDTHLPKTVSGRKRQKVNAETLLDYGRKLSKFSSAPPGYNPETGQDAKAPVHYPWPSEDQMRKTLLFQFSTSMVPNLSATASQLFSEQPPKTNEPTETETEIDANKAVEEKTKMNYPASPTFTTQEENKEVESPANKDVFAGFDLFDPEMEEDF
The following text describes a protein:
Function:
Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 2930 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRTNMDTRHAHSALLAAPQSATANSRSSNSSSESSSNKNNINVGVGDDSGNVSAVSIDDGPHFRDIFHYGHEENYKLASSGITNLNSSSHAHQTLSPISISNASTPESFPEHPLGLERETEPALEAEMEAEELPPHQSKYLLSSIKATKRLKDARPFLKPVDPIALNIPHYFNYVQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAKRIQKYFEKKLSAMPPRVLPASALKKTSRNRKKNEDMDSPLVIRRSVSTTNDNIGESGNREGVSGGRPKRTIHPPKSKDLFDIYENSKPKSKTLQKKFRTCLKILKVLMSKKNSDINFPFLQPVDPIALNLPNYFDVVKNPMDLGTISNNLMNWKYKTIDQFVDDLNLVFYNCFQFNPEGNEVHSMGKKLKELFNFHWLENQDILNEIETDSDLEEDNYSSSYSSDDEYDDEDINENDITNPAIQYLEQKLKKMEVELQQLKRQELSKLSKERKRKHLGKTLLRRKAMKHSVDDLKKSITDKINELSDLEMNGMIRIIKNSLPADEILTSNEDEIEIDLDILDEATIARIYERYFEKKNNNNSKRKLSGNYSTAPTNKKKKTLKFLEKDEIINNNNYSDSEEDSSDSSDSDSD
The following text describes a protein:
Function:
Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.
Sequence:
MEKMTNIFVYGTLKRGQPNHTVMTCYKHGKAVFKGMGKTVEKYPLVIAEEANIPFLLNIPGTGRRIIGEIYSVDDSMLQFLDDFEGCPNWYQRTSQGIEILEWDGTDDSPEERPAVKSIITCFLYSTTCYQPHWLQLPYHKCYDTFGNHGLPYLKHRDIN
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRTENSENFKDKINVVTSVMAAVYGGDPSRRTPQAICICPTREIAQQVLMQADMFLTKLTSMCKRSTEKGSMWVTMKRCERPPTLTAGLCGVGCRFDGFNNSDVMSCSMCAVSMKCQARLKKMTSKGEPVEYRCLVCATDGKRNISTSVLFTFSLLLVRHYVCWMCFALILCLMVIRLPLFSPLVCYDLNYRSNICIFPSCICCMN
The following text describes a protein:
Function:
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.
Domain:
The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.
Sequence:
MAQNSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPEDNRMNRNRLLHINLGIHSPSSYHPGDGAHLNGGRTLVHSSSDGHIDPQHTAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIFIRQTSQSSSGRQTPQNAPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSVYHSPPPSQCPSPFSSPQHQVQPPQLGHPSSHVFMPPSPSTTPPHLYQQGPPSYQKPGSHSVAYLPYTASSLPKGSMKKIEITVEPSQRPGTAITRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCAPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGNHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKAEVNSMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSTNRQLQINVDCTLKEVDLLQSRGNFDPKAINNFYDHIEPGPVVPPKPSKKDSSDSCAIERKARRISVTSKAPVDIHDAQAAAADEHLSICKQSARTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT
The following text describes a protein:
Function:
Critical component of the membrane-bound oxidase that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNEKKELQQELELQEFQTPKNQQLEKLQEPNGEISSTGNETSESGISSPPISQNDNSNNENESLNITPNKPFVSMQEELQNLDIENIPIPPTIQTPKIYKNTNNLIHSKNNLSLPISLSQENIVKLDKVDIESNDQVNSNTDNNNNTNNNNNTNNNKNEKIGLRSKIFKSKIFIKIRGWWWHRGISTYIMLFYIALNIGVGVHMFYNMYHSDIFKFLGLSFCFSRTAARLINLNSAVILLPVLRNFLSWLRGTIVNNYIPIDKHLNFHKLCAFMLFCCTIIHCVGHYISFKKINDDVLKIDDGKSVAGDYLNININNFPDEKYLFFKSVPGITGHIMLLILILIVSSSMWRIRRPMFEIFWYVHHLFIPFYILLCFHGYSKILKKDPQSWMWIIAPFILYSIERLIRIARSKKRVILEKAIMHPSKVLELRMKRDNDNFNFKPGQYLYLNCPSIAYHEWHPFTITSAPDDPFISVHINIVGNWTRKLFKLLNPDNKLGLIQEDLKSTQNRGKRRILKIDGPFGAPAENFFKYRNLVLIGAGIGVTPFSSILRHLKNQNDKQTNADENHLKINKIYFIWISRQKNSFQWFTDILAELENDERIDSILEIHIFLTGALELDDYAKIKNAQKCHITNLHSKTLFGRPNFRSIFNQLTQLHQREKIGVFYCGNKALGKNIIKNCNKFNGKNNCHLIFHKENF
The following text describes a protein:
Function:
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLPLTYVVKAFSIGLFFSLFLMKPLISWLKKQGFQDHIHKDHCEKLEELHKDKAYIPTAGGIVFVFASVLAVLLLFPIQLWSTWFCIGTILLWGALGWCDDQIKNRRRVGHGLSAKHKFLIQNCLAAGVVLPIMFAYKESFLSFHLPFLGIVSLPHHWWSYLLSFAIATLAIVGTSNSVNLTDGLDGLAAGAMVIACLGMLVVACTNGAPWAFICCVLLATLAGSCLGFLRYNKSPARVFMGDTGSLFLGAMLGMCAVLLRAEFLLLFMGGIFVLESLSVIVQVGSYKLRKKRVFLCAPLHHHYEYKGLSEKAVVRNFLIVELICVVVGIIAVFVD
The following text describes a protein:
Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Sequence:
MQSGISVSQELHDAFSRFASDTSIFCLPVTITAERLTPLSTLPFSGFGENAFYASLSQLTSVLEPKTPIYLLIRRTGSNLIALTYIPSNAGVRAKTLFASTRATLVRELGSEKFSETIFATDEEEVIGENAWKEREAEKNGTSTGGYRREDLMGEKERELEAVRRAEEAARSGTPGRDIGIGGTFARGPSRMKIEMQVDEDAKNALGGLQQGGLVQMAIDVSTETFKLTAAESGVDANSVQNHISASSPRYTFYHYPDSDTIIFIYTCPSGSSIKERMLYASSRMHALQVAEEQGLKILKKIEAGAPDEVTGERLQEEVNPPQNNGLRQGFAKPRRPGR
The following text describes a protein:
Function:
Required for chromosome pairing and genetic recombination. MER1 may function to bring the axial elements of the synaptonemal complex corresponding to homologous chromosomes together by initiating recombination. MER1 might be responsible for regulating the MER2 gene and/or gene product.
Sequence:
MSNQHSPQPFCLDTKLVKLLEELQEGKQFNNKNIFPEKALYLKLALDYSFFRKNLLEFCVHLDKIKGVIRPNYDTIYILCLLEVDLLNLVFTDNILEICLPRFVSREDLRVFNNTFYTYHDNRLRILQEDFSQLFKKIKTKASVLCFTVEEIFLTNQEILPQNSTVAELQKSTNKVQTNGPQRHDFIVTLEIKLNKTQITFLIGAKGTRIESLREKSGASIKIIPISDKMTAHERNHPESVQQTILISGDLYSIALAVTSIESALITLDL
The following text describes a protein:
Function:
Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody.
Sequence:
MESGPRVEPGPGAPAAVLARIPQEPRPSPEGDPSPPPPPTPMSALVPDTPPDTPPAMKNASTPQQLPLEPVSPTGQVSPQPAPPPDECPSSEAKSRGPTPTATGPRDAKPSQRSSQPSPTAVPASDSPSAKQDVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHNSPGRKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGSGPGRRPTRARAGASLAPGPHPDRTHPSAAVPVCPRSASASPLTPCSAPRSAHRCTPSGERPERRKPGAGGSPALVRRRLEATPVQKKEKKDKERENEKEKSALARERNLKKRQSLPASIRPRISTGAELSTKSKARPTSPSTTWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRIRRKEEAKESPSPSGPEDKNHSKSRTAEEKEPAAPASPAPSPVPSPTPAQPQKEQSSTQIPPDTAVPAVPTVPTFPTAPPTAAPSVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERKLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQKEEQERQERRKRLEEIMKRTRKSEAAETKKQDGKETMANNSGPDPVKAVETRPSGLQKDSMQKEELAPQEPQWSLPSKEMPGSLVNGLQPLPAHQENGFPAKGTAGDKSLGRAAEGLLPFAEADAFLKKAVVQPPQVTEVL