lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probable cyclic nucleotide-gated ion channel.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.
Sequence:
MFDTCGPKGVKSQVISGQRENFVRLDSMDSRYSQSSETGLNKCTLNIQGGPKRFAQGSKASSGSFKKGFRKGSEGLWSIGRSIGLGVSRAVFPEDLEVSEKKIFDPQDKFLLLCNKLFVASCILAVSVDPLFLYLPFINDKAKCVGIDRKLAIIVTTIRTVIDSFYLFHMALRFRTAYVAPSSRVFGRGELVIDPAQIAKRYLQQYFIIDLLSVLPVPQIIVWRFLYTSRGANVLATKQALRYIVLVQYIPRFLRMYPLSSELKRTAGVFAETAWAGAAYYLLLYMLASHIVGALWYLLALERNNDCWSKACHNNQNCTRNFLFCGNQNMKGYAAWDNIKVSYLQLKCPVNVPEDEEPPFDFGIYLRALSSGIVSSKNFVSKYFFCLWWGLQNLSTLGQGLETSTYPGEVIFSITLAIAGLLLFALLIGNMQTYLQSLTIRLEEMRVKRRDSEQWMHHRMLPPELRERVRRYDQYKWLETRGVDEENLVQNLPKDLRRDIKRHLCLALVRRVPLFENMDERLLDAICERLKPCLFTEKSYLVREGDPVNEMLFIIRGRLESVTTDGGRSGFYNRSLLKEGDFCGDELLTWALDPKSGSNLPSSTRTVKALTEVEAFALIADELKFVASQFRRLHSRQVQHTFRFYSQQWRTWAACFMQAAWRRYIKRKKLEQLRKEEEEEEAAAASVIAGGSPYSIRATFLASKFAANALRSVHKNRTAKSTLLLSSTKELVKFQKPPEPDFSAEDH
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MAIKIGITGGIGSGKSVVSRLLEIMGIPVYISDIEAKRITHTNDVIRRELCALVGQDVFLNGELNRPLLASYIFGSPEHAKKVNAVIHPQVKEDFRRWVKGKGDIAMVGMESAILLEAGFKQEVDFVVMVYAPLEVRVERAIRRDYSSRELIMKRIEAQMSDEVKRNHADFVIVNDDETPLIPQVLKFISLLSKNNHYLCSAKK
The following text describes a protein:
Function:
Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Nucleus outer membrane; Single-pass type I membrane protein.
Sequence:
MQGAVARVFVVVAAAILNHPLLFPQENTTLPEQDEELMARMREHEEKLEMELAKLESEILELESKQEEGTSRDAYMWYFWSSVSFVIFFVIEMCRVELAETEIRNLEDEEDGGSITPRMMVLDKDILRNFCDKCSYSSAHENWKVREFVEGLADDLLESLRSVCDRDTDMEVGDFVGIGSMFESWKVCGPLVCDLMVPFSPPHPHFFQSQMWCSSDQIPLDMQGSGRIRATRFGENDEGCLCSAANMGDDMLCLLHSTADRQNAGPNPDELLCLKNTDILSKDQVMKWFQISVTKAWGRISHKYDFQVLFRNLDAAGALKVRFRSGKVILLNLIPVVQLEDTDAYFVSHFPSGWDSPPDPFWPLSLAVYERNLLKYFAKRLPQDSCHSHCLQIAAFLNRKQTELTGKSFLSSYHLKTVLLHVLLSTKTTAWRAGNMEHRLRDVLGLLHQSLLEKRLHHALVGNRKVPEVLQVPGVIRKAEPINLFRSLVLQRQLYAATVRHLQEILKNASIVIQEYVPRPSNNGFNLSLDEGFNC
The following text describes a protein:
Function:
Involved in fertilization ability of sperm.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (By similarity). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity).
Sequence:
MKPVVLVALLWLWPSSFLAYPTATVLPDEEQNLNHYVQILQNLIMSVPTKEQGFGRKFRSSRTVDGAEARSLSSEMLLTPGLVSAQEVTTPETEVMLTSMVEKTTFPSSGFTMESEKRRTHSKAFWSIQPNNVSIVLHTEEPYIEKEPEPEPELETEEESRRLATEPEPEPESESAPETETRQTAESEEEVETSTAQNKVRTGTSRMSTVITQTTNTQGTPNTVTVKTINNLDVSTESEDVPQLSGQSEILNVEDLPGHHSLSTRHENILRKISNINSQIHQGLLSDHSSPAYKEFIKASREHLKRSLALAAAAEHKLQQMYGSNVFLDGHTSDPDDDMEVIINMLYNSRSKLSDYFTINHVPSELREKATVVIAVLKKILCVDQVEMQSLIRKLLSNNMKILNILNVP
The following text describes a protein:
Function:
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASQASLKLQPSNQSQQAPPNITSCEGAPEAWDLLCRVLPGFVITVCFFGLLGNLLVLSFFLLPWRRWWQQRRQRLTIAEIYLANLAASDLVFVLGLPFWAENVGNRFNWPFGSDLCRVVSGVIKANLFISIFLVVAISQDRYRLLVYPMTSWGNRRRRQAQVTCLLIWVAGGLLSTPTFLLRSVKVVPDLNISACILLFPHEAWHFVRMVELNVLGFLLPLAAILYFNFHILASLRGQKEASRTRCGGPKDSKTMGLILTLVASFLVCWAPYHFFAFLDFLVQVRVIQDCFWKELTDLGLQLANFFAFVNSCLNPLIYVFAGRLFKTRVLGTL
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGKAAKSSRKGKKAWRSNISTDDIDEFYEKQTRDAHAGAAAIPSLPSGSLFFVDKPASASTSSAANASDPAPKDVPVKRKIEKNREKVLHHESVLKRNPYIQTIPSSLMSKKDKKKFKKHAKKKELQESREEKSVPMEEDSAEKNLDIWGGDAKGAALPKKGMKRLKKNKSTTSVIPAVEVEPQGCSFNPPHEAHQDALALAVADEMRKIYTKELGPTPVPLTVLGQAVAEEDKFFLDAADDGDAAVDGDVDAAEGDKDQDADALTGERKKTKRVTRVELNKRARRKERLRTEADAKKLEVFSKQIDSLPNILEEIAKEDKEKEEKRIRLTVAKQERLKSAPRRLGRHKFEPAPVQVLLTEEISGSLRKLKGCCNLARDRYKSIEKRGILAPNKKLSKRPRR
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of the 2'-O-methyluridine corresponding to position 2791 in S.cerevisiae 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Subcellular Localization:
Mitochondrion.
Sequence:
MFGSKTLFSWAAKRSKDFYRKKSKIDNFRSRAAYKLIELNSKYRFINKEDVVIDVGFAPGSWSQVAKKLVGNKGKVIGIDIQHIAPPEGVLPIYGDIRDPNTLTKLFEALRLLHEPNTNDSIDCRVVDAVISDMLHKATGIRIRDHALSMELCASALHVALTFLKSNGSFICKFYMGDEDADLQNLLKSHFRFVQVMKPKASLKESREAYFVCLERKP
The following text describes a protein:
Function:
May be part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTINTDDQYGDAESKTTISSSRRYSSSSYQDQSMDDALNTTLTNDKATLIQVWKPKSYGSVKGQIPQCERLTYTWKEIDVFGEAPTDGKPREPLCTRLRNCCTRQRKDFNPRKHLLKNVTGVAKSGELLAVMGSSGAGKTTLLNALAFRSPPGVKISPNAVRALNGVPVNAEQLRARCAYVQQDDLFIPSLTTREHLLFQAMLRMGRDVPASVKQHRVQEVLQELSLVKCADTIIGAPGRIKGLSGGERKRLAFASETLTDPHLLLCDEPTSGLDSFMAHSVLQVLKGMAMKGKTIILTIHQPSSELYCLFDKILLVAEGRVAFLGSPYQSAEFFSQLGIPCPPNYNPADFYVQMLAIAPAKEAECRDMIKKICDSFAVSPIAREVLETASVAGKGMDEPYMLQQVEGVGSTGYRSSWWTQFYCILWRSWLSVLKDPMLVKVRLLQTAMVATLIGSIYFGQVLDQDGVMNINGSLFLFLTNMTFQNVFAVINVFSAELPVFLREKRSRLYRVDTYFLGKTIAELPLFIAVPFVFTSITYPMIGLRTGATHYLTTLFIVTLVANVSTSFGYLISCASSSISMALSVGPPVVIPFLIFGGFFLNSASVPAYFKYLSYLSWFRYANEALLINQWSTVVDGEIACTRANVTCPRSEIILETFNFRVEDFALDIACLFALIVLFRLGALLCLWLRSRSKE
The following text describes a protein:
Function:
Potential transporter for phosphate.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVGAEAATFVVAAVASLFMAWAIGAGSSGSTPFAPAVGANAITVMRAGFVVGILGLAGAVFQGANVSEAVGGDLIVGMPLSPLAATIALSTAALLVAAGVFAGYPIATAFTVTGAVVGTGLAMGGGPAWPKYQQIATLWVLTPFVGGGTAYVTARSLRDTAHERVLVPALAGGVGAITANIEFAFLGGPDAARSIAWSLASVAGTPSLVGRGAATLAVAAAVAGALYCDSAGNASRGQRHFLLALGGLVAFSAGGSQVGLAVGPLLPLIGGEIPLPYVLSGGGVGLLVGSWTGAPRMIKALSQDYSSLGPRRSIAALIPSFAIAQSAVFFGIPVSFNEIIVSAIIGSGYAAAGGGGGGVSGRKMAVTVLAWVASLVVAFAASYGVFAAVSAVM
The following text describes a protein:
Function:
Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MIVGTAGHIDHGKTSLLRALTGIEGDRRPAERQRGITIDLGYLYADLGDGSPTGFIDVPGHERFVHNMLAGASGIDCVLLVVAADDGLMPQTREHLAIVELLGIRRALVALTKIDRVEPQRVQQVRTQVEHLLASGPLARSPIFPLSSSTGEGVEALREALGGLAGEVRERSREGYFRLAVDRAFSVAGSGIVVTGTAFSGQVAVGDELLLGNAGRPVRVRGLHAQNRPAQQAWAGQRVALNIAGERLALEQIQRGDWLLQAALHAPTTRVDIDFRLLPDELRDFTHWTPVHLHLGTQDVTGRLALLEGEQLEPGHRAFAQLVLNAPIQALHGDRLVLRDQSAQRTLGGGRVLDGAAPARNRRTPARLAQLQALRQESLEEALPTLLGAAENGLDPQRLVQSFNRPREHWRLPEEVVEVQTRLGPRLFAGERWFALVEQLLAGLRRFHEELPDELGPDRDRLRRYALPQLERPVFIALLDAALAGGDVHSSGPWLHLPGHEVRLSDSEEQLRARLWPLLEAGRYDPPWVRDLARELRQDEAVMRNLLRKLARLGQLQQVVRDLFYPEATLRQLAEIAVQVRDPAGLIRPAEFRDRLGIGRKRSIQILEHFDRIGLTRRIGNDRRLREGSALAEQLLGGVSP
The following text describes a protein:
Function:
Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates. Acts on propionate 3-nitronate (P3N), the presumed physiological substrate. Probably functions in the detoxification of P3N, a metabolic poison produced by plants and fungi as a defense mechanism.
Sequence:
MKKSIFSHMVGIKYPIIQGGMAWIADSSLAAAVSNAGGLGIITGNAPVEWVRQEIRKTKELTDKPFGVNIMLLAETADEIAQMVCDEGVKVVTTGAGNPGKYIKKWKEHGIIVIPVVPSVALAKRMEKSGADAIIAEGCESGGHVGELTTMTLIPQVVDAVDIPVIAAGGIGDGRGIAASFMLGADAVQVGTRFLVAKECTVHQNYKNKVMKAKDIDTQVTGRPTGHPVRIIRNRLSRKFQILEKEGAPLEEFEKLGRGALSKAVIEGDIDNGSVMAGQIAGLINKEQTCSEIINEIFDEAYTLLDYK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes. Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC.
Subcellular Localization:
Postsynaptic density.
Sequence:
MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSLACSKDLTLLWIKQIKSILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQMLCYCQKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
The following text describes a protein:
Function:
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity); Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway (By similarity).
Subcellular Localization:
Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity).
Sequence:
MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIENRWIAFQILTAVDQAHKPGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKTEEEPKENGLVILVSVITSCLQTLKYYDSKLAALELILHLAPRLGVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFVTVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEDEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSPQVPEVTTIQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIRNSQKMEGKTTTTRSILTYSRVGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK
The following text describes a protein:
Function:
Participates in fat metabolism regulation by recruiting FOXO and the TSC1-TSC2 complex to the cell membrane, which positively regulates TOR activity and negatively regulates the expression of FOXO target genes. Involved in R8 photoreceptor subtype specification. During early embryonic development, may be required for ectodermal patterning.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain:
The PH domain is required for membrane targeting.
Sequence:
MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRVLSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIALPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPEAVTPHAPLLMPLLPQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILLKLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHLPTQALLQQEATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSLNSSSPSPPLKPVPVGAPAINTTIVQPASVVSATPTPPPSSASAPIASSTPVSAATPTPQHAGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLSNSQINQQPGGSSNGNVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPVTSGGVTVTTSPSKVRPHSQGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPALPQSASNGHAKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIRGPHCLYSKTCFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCENRSFTELVTSQFPQVKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSCKGSSGGESIDVNQIRSVKVSRGARNIPKAFEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKTNSLPARSIGSSKPSF
The following text describes a protein:
Function:
Catalyzes the attachment of tryptophan to tRNA(Trp).
Subcellular Localization:
Cytoplasm.
Sequence:
MKKKRVLTGDRPTGKLHLGHWIGSIMNRLQLQNDSRYDCFFIIADLHTLTTKTRKEEILQIDNHIYDVLADWLSVGIDPEKSAIYLQSAIPEIYELNLIFSMLTPLNHIMGIPSIKEMARNASLNEESLSHGLIGYPVLQSADILLAKAHLVPVGKDNEAHVELTRDIAKTFNRLYGEVFPEPDILQGELTALVGTNGQGKMSKSANNAIYLSDDAKTVQEKIRKLYTDPNRIHATTPGRVEGNPLFIYHDLFNPHKEEVEEFKTRYRQGCIRDVEVKARLAEEINLFLNPFREKRSELVAQPKFLEEALQQGTEKMRTVARETMEEVHDHLGLSRKWRTILASSK
The following text describes a protein:
Function:
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. May also be involved in transcription regulation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADSDVKKVTKGEKKTREAMKKLGLAPVSDIFRVTIKQKEGVLVVVAEPEVYASPSGETYVVFGDHSFDDIASRLQKAVPKANVDDIVKAAMPAPTAVKESEESEEIVAQAVDSFDYKGVNPKDVEVVMKETKASREKVVETLIATKNDLVSAVLELTTN
The following text describes a protein:
Function:
Polymerizes as an extended helical structure around the baseplate-tail tube complex. During ejection, the sheath shifts to a contracted form, thereby making the inner tail tube protrude through the host cell envelope.
Subcellular Localization:
Virion. Host cytoplasm. Note=Tail.
Sequence:
MSDISFNAIPSDVRVPLTYIEFDNSNAVSGTPAPRQRVLMFGQSGSKASAAPNVPVRIRSGSQASAAFGQGSMLALMADAFLNANRVAELWCIPQGNGTGNAAVGEISLSGTAGENGSLVTYIAGQRLAVSVAAGATGAALADLLVARIKGQPDLPVTAEVRADSGDDDTHADVVLSAKFTGALSAVDVRWNYYAGETTPYGIITAFKAASGKNGNPDISASIAGMGDLQYKYIVMPYTDEPNLNLLRTELQERWGPVNQADGFAVTVLSGTYGDISTFGVSRNDHLISCMGIAGAPEPSYLYAATLCAVASQALSIDPARPLQTLTLPGRMPPAVGDRFTWSERNALLFDGISTFNVNDGGEMQIERMITMYRTNKYGDSDPSYLNVNTIATLSYLRYSLRTRITQKFPNYKLASDGTRFATGQAVVTPSVIKTELLALFEEWENAGLVEDFDTFKEELYVARNKDDKDRLDVLCGPNLINQFRIFAAQVQFIL
The following text describes a protein:
Function:
Transporter for the intake of S-methylmethionine.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQTTQQNAPLKRTMKTRHLIMLSLGGVIGTGLFFNTGYIISTTGAAGTLLAYLIGALVVWLVMQCLGELSVAMPETGAFHVYAARYLGPATGYTVAWLYWLTWTVALGSSFTAAGFCMQYWFPQVPVWVWCVVFCAIIFGLNVISTRFFAEGEFWFSLVKVVTIIAFIILGGAAIFGFIPMQDGSPAPGLSNITAEGWFPHGGLPILMTMVAVNFAFSGTELIGIAAGETENPRKVIPVAIRTTIARLIIFFIGTVFVLAALIPMQQVGVEKSPFVLVFEKVGIPYAADIFNFVILTAILSAANSGLYASGRMLWSLSNERTLPACFARVTKNGVPLTALSVSMLGGVLALFSSVVAPDTVFVALSAISGFAVVAVWLSICASHFVFRRRHLQQGKALSELHYRAPWYPLVPVLGFVLCLVACVGLAFDPAQRIALWCGLPFVALCYGAYFLTQPRNAKQEPEHVAE
The following text describes a protein:
Function:
Cell wall formation.
Subcellular Localization:
Cytoplasm.
Sequence:
MYQYKRIHFVGIGGIGMSGIAEVLHNMGYTVSGSDIKESDTVRRLKKLGIKVFIGHSSDNIDNTEVVVFSSAVKPDNPEIIKARSLGIPVIPRAEMLAELCRLKYSILVAGAHGKTTTTSFIATILSDAGFDPTIVIGGKLKSIGTNAKLGQGEFLVAEADESDGSFLKLSPAVSVITNIDREHLDYFKNLKRIKKAFLEFANKVPFYGVSVLCRECRHIRDLIPHLTRRYVTYGFDEASDFCAKNIEYSSSKVLFDAFFRNKFLGRFAITVPGNHNVLNALATIAVAKELSIPIEKVRESLENFTGISRRFEFKGEKNGVKFYDDYGHHPTEIKAVIKTALWLKPQRLCVIFQPHRYTRTRDLMEQFIQVFKTTLRKNDVLFLMDIYAASEPPIEGVSAEILYEKLKNVGVNVIFNPDKEDIKIDILRELKEGDLVFTIGAGDVYKVGESIKEKL
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MIPREVIEEIKEKVDIVEVISEYVNLTRVGSSYRALCPFHSETNPSFYVHPGLKIYHCFGCGASGDVIKFLQEMEGISFQEALERLAKRAGIDLSLYRTEGTSEYGKYIRLYEETWKRYVKELEKSKEAKDYLKSRGFSEEDIAKFGFGYVPKRSSISIEVAEGMNITLEELVRYGIALKKGDRFVDRFEGRIVVPIKNDSGHIVAFGGRALGNEEPKYLNSPETRYFSKKKTLFLFDEAKKVAKEVGFFVITEGYFDALAFRKDGIPTAVAVLGASLSREAILKLSAYSKNVILCFDNDKAGFRATLKSLEDLLDYEFNVLVATPSPYKDPDELFQKEGEGSLKKMLKNSRSFEYFLVTAGEVFFDRNSPAGVRSYLSFLKGWVQKMRRKGYLKHIENLVNEVSSSLQIPENQILNFFESDRSNTMPVHETKSSKVYDEGRGLAYLFLNYEDLREKILELDLEVLEDKNAREFFKRVSLGEDLNKVIENFPKELKDWIFETIESIPPPKDPEKFLGDLSEKLKIRRIERRIAEIDDMIKKASNDEERRLLLSMKVDLLRKIKRR
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MCDFIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDKTILVVTITLKRAAMQRAEEQSWQLANALNCHVQTEDV
The following text describes a protein:
Function:
Involved in the biosynthesis of the lanaridin cypemycin.
Sequence:
MNVEKFEGAELHVHVTGSISAALVPWWIHWLREFQPELVVNVSVTPAASRFLAVRALRHLANGKVWVDSWDDPDVPPEVNSGKSGASECFLVFPATLDTVMRLAQGRADSPALMMLQLTDAPLVIADTFPGSNEIVENNVQTLKLRPNVEFAPRVNGVRASNRQTAEVGFNLPGALAAANRMRKEGRSGE
The following text describes a protein:
Function:
Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon. May act as a direct hypoxia/oxygen sensor. O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation. Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation. Binds a number of gases; O(2), NO, CO. May be a secondary sensor for CO. Donates a phosphate group to transcriptional regulator DevR (DosR).
Subcellular Localization:
Cytoplasm.
Domain:
The isolated ATP-binding domain (residues 451-573) crystallized as an asymmetric, domain-swapped dimer without ATP.
Sequence:
MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR
The following text describes a protein:
Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKMLTRLQVLTLALFSKGFLLCLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLVIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKHNHRRPCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFIANKGVDSIVKFDTFGDGMGQYNVFNFQYVGGKYSYLKVGHWSETLSLDVDSIHWSRNSMPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGLGQWPTADLSGCFDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFISKPSPVICALRRLGLGTSFAVCYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVVVSVWLILEAPGTRRHTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYMPTVCNGREVLDSTTSSL
The following text describes a protein:
Function:
Involved in the glyoxylate assimilation cycle used to regenerate acetyl-CoA and produce pyruvate as universal precursor for biosynthesis. Catalyzes the reversible dehydration of beta-methylmalyl-CoA ((2R,3S)-beta-methylmalyl-CoA) to yield mesaconyl-CoA (2-methylfumaryl-CoA).
Sequence:
MSAKTNPGNFFEDFRLGQTIVHATPRTITEGDVALYTSLYGSRFALTSSTPFAQSLGLERAPIDSLLVFHIVFGKTVPDISLNAIANLGYAGGRFGAVVYPGDTLSTTSKVIGLRQNKDGKTGVVYVHSVGVNQWDEVVLEYIRWVMVRKRDPNAPAPETVVPDLPDSVPVTDLTVPYTVSAANYNLAHAGSNYLWDDYEVGEKIDHVDGVTIEEAEHMQATRLYQNTARVHFNLHVEREGRFGRRIVYGGHIISLARSLSFNGLANALSIAAINSGRHTNPSFAGDTIYAWSEILAKMAIPGRTDIGALRVRTVATKDRPCHDFPYRDAEGNYDPAVVLDFDYTVLMPRRG