lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSNLTVNVIEEKNLGDNKPCVLKFSQGLPPLSFIEKEPEFISMSTKNKRHRVVLTNTDQLEYESEDKDSKYAKYAIGIFDKNTKQLKIVPTKIQTMNQSVIGYTLTLDSSSVISREERYDKIKKLADSFGSKITKKKMQKMEMENVENLDYEKTTKSIDAVKNELADIESNEKPFDLPDFDAETNDVRKIYNIEAILPPRIFFGLNHQPFLDIISKTSEAPSYLPEYFKDQLKRFEDIKDEEKVVYNCKLLTFMWYSMILMKSKGGHEPLIKEGCTSEVINFLVSIFGSKINHKKYNISQDDKLKIYNYLAIFALKLEDFQITDIKSLAQSLSLTSSSFEKHFTRVGCKVVRIGSEKRSVRLEAPLKLPKARFSN
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGKVIRSDRKGVQRIRARDIVPGDIVEVAGMPGGSSFYFIFFLFYFIFEMESCPVAQTGVQWRNLGSLQPPASQVQAILLPQPPIGASFFYYMGLGAPSLSVPPSFGLYAQRGWPSDPSKALWPKPCWTDETVGQRDRGPPERSQLSHSTPSPSLGSWEPFWLFPAGGAQSHSQPSHSPRTVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAISDPRAVNQDKKNMLFSGTNIASGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGNLPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNAVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPAGQGSKMFVKGAPESVIERCSSVRVGSHTAPLTPASREQILAKIRDWGSGSDTLRCLALATRDVPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCHQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVVGKAYTGREFDDLSPEQQRHACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRNPREALISGWLFFRYLAIGVYVGLATVAAATWWFLYDAEGPHVNFYQLRNFLKCSEDNPLFAGVDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLAAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVVLLDEAFKYLSRNHVDGILRTVSQAWSRQPMTASWTSDHTGARGTASSRCQSHSEREEAGVSSRSWDLRRGSGCVAELRCGGLGWAGQ
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MENDSEKPAVGPLRRKPPTSPIGPPIPIYVSNGEAYIWAVDQVERLRIDYQISGLLTGTLPQLAQQNVFLGLPLQLMPEEVVVLVELGIAVLVDDLKAHRPATVEESTEYQARRDQEIAEERRLTAIREGERRAAAQEVYRSQIAAADQKRRARQQKPPSRTEDGGEGSEEIQQGMLVPDGLDEKSKPAISPVQVPYFVPIHLQSHTPTHTPDHPDVVHHQLDSARRAGLWTFPDNQFQRARSAVFSALWRQGMFLGIGLKFGCDFLVYPGDSLRFHSHFACTVVQDPHKPIAPLSLVSYGRLATAVKKSHLLACWDEHSQAVRFLSLEWARDGF
The following text describes a protein:
Function:
Probable transcription coregulator. Required for asymmetric cell divisions of the T hypodermal cells, and cell fate determination, in concert with homeobox proteins nob-1 and ceh-20. Acts downstream of the Wnt signaling pathway, and of ceh-20 and nob-1.
Subcellular Localization:
Nucleus.
Sequence:
MTSEPSTSSEAGSSSLLDADKTNLLQEALVRAGVIRSQRQGISPTATNIKSPKKSALFEKIASHPLMPIVELLLEKCETAATTFDRKAFETDDIKRLFQSLEQRGVQLSSNRDEVDELMETAILALRTCMVELERVYSLMESFKAKYLATLRRTVCHEALVGNNGDSDDELSDNPLMPVLEMSEAAFQAQNKAMESALATLQSVSGSLSLPLQFTHQSITAAQIERNLEFLKQCGFPTQLPPNFLKPSNEKSPEKSEEEKSQKPSSSPKSPSLSD
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity.
Sequence:
MKPSLAADEMFSEGPGYMEMDESGGATGMMMDHLPSNDKHVHADFYNDFDDLFDEDNWAKMKTDGKQ
The following text describes a protein:
Function:
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MLTAPLNLPKWLEENSHLLKPPINNYCVYNKDVTVMIVGGPNARTDYHINETAEWFYQYKGAMMLKVVDEGEFKDIIIGEGEMFLLPPNTPHNPVRFANTVGIVLEQPRPKDSLDRLRWYCTNCREVVEEAAFHCTDLGTQIKEAVNSFKDSEERRKCKKCGTVAESAPPPGSIQDPNLS
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC41.
Sequence:
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALLDQEAQWWSGHDDAAL
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
AMKFVVCGGGISGLASAYYLNKALARTTSKPYKIFLIEKSTNVGGWMKTNVRNVYQGAINERGPRSVRTAGLVGNNTLQLISDIGMESNVIPVRSDDIAAKQRLLYVNKKLHILPNSLLSACKKQQPFSNSLARSFVGGLLKKVPPSYETMSEICSERFGREVADYLVSAFVRGVFAADSKQLSMKAAFPPLWGRLGPREVCQHYIKRAKREKWTQWGVDNGFSYLTDNLEQQLAQVDNIEIIKYTNIDEIMMQNNGKMMMSTTTIRRVDHTISALPSYALSRILKNSNKQSLGIMLSHIKWVDVGVVNVEFSGKPNEILPHVGFGHLVPSSEPSSVLGIVYDSCAFPQHDRVNMPTTRMTCMMGGSWFRELFGEPNLVSNQTLESAALGSISQQLGIHEDPMNVDTTLCKKCIPTYRVGHTDLVENIEDFISEHDVPLSLVGASYWGVSINDCIFNSRVAVNNILKKY
The following text describes a protein:
Function:
Involved in the transport of maltose and maltodextrins.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKVSVIAAAVAATLAAGSAFAVDFNGYFRAGTGISGNGNADQAVNKAGTGRLGNENDNYYEFGFAEELKTGEQTWKVESMIAQGNSGANGWEDGDFNVAQFNVQAKGLLASDQEAVMWAGKRYYQRKDIHITDFYFLNTSGTGGGIENLSVGNQKLSVALVQDGDNTNSSGYIFDARLANIGLWENASLELAMAYNFATEKDSKNEVADDGVLVSAILHQGLSNGFNQTVFQYGTAGYGAQAANFWGAGSYYARGTEAFNDASGFRLLNWGVINLGENWEMGHQLAYLAGSDIGGQFGGDGANKNTYTGKSFDIDQYSVVVRPMYKWNDTMRTVFEAGYNAGEKISNGGLATEDFGNAKFTVAQAWAMGDSFWARPELRVYGTYLLDTENDKAFGDDDTEFVVGIQVEAWW
The following text describes a protein:
Function:
Possible non-essential role in spermiogenesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MQLLPPPLRTGTKTQMDAKKPRKCDLTPFLVLKARKKQKFTSAKVGSKPSVQVQKPPSNIKNSRMTQVFHKNTSVTSLPFVDTKGKKNMVSFPHISKKVLLKSSLLYQENQAHNQMPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDMAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVERIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDMAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDAKGFPKTITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGRHHSSRKDEVTKETTEKTKDGPTKHVQHSGDQQDCLQHGADTVQLPQLVEAPKKSEAAVGAEVSMTSPGQSKNLSLKNTNILPPIV
The following text describes a protein:
Function:
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Sequence:
MTAVNVALIRDTKWLTLEVCREFQRGTCSRADADCKFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKTAAAMFAQQMQLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRGNCTRGENDCRYAHPTDASMIEASDNTVTICMDYIKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLKF
The following text describes a protein:
Function:
Participates in the assembly of the viral procapsid in the cytoplasm. Forms first a 12S pre-assembly complex with protein H, and F and G pentamers, then twelve 12S complexes are joined by the D protein to form the procapsid. Internal scaffold protein B is released from the procapsid upon genome packaging. Autoproteolytic activity cleaves protein B and probably facilitates its removal through the pores of the procapsid.
Subcellular Localization:
Host cytoplasm.
Sequence:
MEQLTKNQAVATSQEAVQNQNEPQLRDENAHNDKSVHGVLNPTYQAGLRRDAVQPDIEAERKKRDEIEAGKSYCSRRFGGATCDDKSAQIYARFDKNDWRIQPAEFYRFHDAEVNTFGYF
The following text describes a protein:
Function:
Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis (By similarity). Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2.
Subcellular Localization:
Secreted.
Domain:
The His-rich (HRR) region contains approximately 12 tandem internal repeats of the 5-residue G[H/P][H/P]PH consensus sequence. HRR binds heparan sulfate and possesses antiangiogenic, antibacterial and antifungal properties through binding Candida cells, and preferentially lysing the ergosterol-containing liposomes at low pH. The tandem repeats also bind divalent metal ions and heme; The cystatin domains can also bind heparan sulfate. Binding is enhanced in the presence of zinc ions (By similarity).
Sequence:
MKVLTTALLLVTLQCSHALSPTNCDASEPLAEKVLDLINKGRRSGYVFELLRVSDAHLDRAGTATVYYLALDVIESDCWVLSTKAQDDCLPSRWQSEIVIGQCKVIATRYSNESQDLSVNGYNCTTSSVSSALRNTKDSPVLLDFFEDSELYRKQARKALDKYKTDNGDFASFRVERAERVIRARGGERTNYYVEFSMRNCSTQHFPRSPLVFGFCRALLSYSIETSDLETPDSIDINCEVFNIEDHKDTSDMKPHWGHERPLCDKHLCKLSGSRDHHHTHKTDKLGCPPPPEGKDNSDRPRLQEGALPQLPPGYPPHSGANRTHRPSYNHSCNEHPCHGHRPHGHHPHSHHPPGHHSHGHHPHGHHPHSHHSHGHHPPGHHPHGHHPHGHHPHGHHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGYGPPHGHSRKRGPGKGLFPFHHQQIGYVYRLPPLNIGEVLTLPEANFPSFSLPNCNRSLQPEIQPFPQTASRSCPGKFESEFPQISKFFGYTPPK
The following text describes a protein:
Function:
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNKLFKSIYTQTKLNIYEFLFAISFLVNFILGRFIHFSAPDEEVYNYYNNKRNILNQWFVKKGWGWTTLVIILFYSNIIYKQYNSKATTNTTTTNNNNNNKQGVIVQTIRNAVINYIVVTIWWIFFTQWCFGLPIMDKIFVLTGGKCSIDTNSMAHFNPNHHHVHANFVQKLENIWESTGITSYNCRRIKGSQWIGGHDPSGHVFLMIHSSLYLFNEMINYWPGWTYIKHNLSQILTSGNDNGNDNGNGNGNGTRSLSIGDKLLLLWNTPQLIIGGLIGLWWFMLLMTNIYFHSSLEKLVGLGFGYIGVAGLYWIPRWLL
The following text describes a protein:
Function:
Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MILIIYAHPYPHHSHANKRMLEQAGTLENVEIRSLYHLYPDFNIDVAAEQEALSRASLIVWQHPMQWYSVPPLLKLWMDKVLTHGWAYGHGGTALHGKHLLWAVTTGGGENHFAIGSHPGFDVLSQPLQATALYCGLKWLSPFAMHCTFICDDDTLQAQARQYKQRLLAWQEVNHG
The following text describes a protein:
Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Sequence:
MDINLANRIARECLAQFAKLPKTGKPNESFEWTILSAIVLVTPAHHAASSDIRVVALGTGTKCLPGDELSPRGDRVHDSHAEVLARRAFVRYLYEQIEQALLVEGGQPKESIFERQTVDGGGCGKFVLKNGHSFHFFTTHSPCGDASIYKREEDALLPAKRARRTDEACSDRADEETTVGCCIGEDRTAVGMTGGKLLDPEAHGDLMAQTIGAVRTKPGRGVRTASVSCSDKLARWNVLGVQGGLLMMLLGRPIYLDGVVVCDGTDHSVVALERAIWGRFERWKEPALREPFERHHRPVVIAADGGELFAYRKNRPHPTKEAGGKFQPSPCGIVWCDVKERPHEVEVAGRRHGVTKRKLATPAARLQISKIELFNRFARTYRRAEREALHNLTVPSSVEGATQPNIAAADDVGKLSYADAKARSVAYATQWASVRATMFGRWPVKPTSLGAFLSDAS
The following text describes a protein:
Function:
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus, nuclear pore complex. Nucleus, nucleoplasm.
Sequence:
MNPVNPFSGQQPGAFAVSSSATGTFQTKSPFRFGQPSLFGQNNQASKSLGFSQVPSFATPSGGSHSSSLPAFGLTQTSSVGLFSGLESTPSFAATSGPSSSSVPGNTAFSFKSASSVGVFSSGPTFGPETGDVAGSGFRKTEFKFKPLENAVFKPILGAESEPEKTQSQIASGFFTFSHPVSSGSGGLTPFSFPQVTNSSATSSSFIFSKPVTSNTSAFAPALSNQNIEEEKRGPKSVFGGLNSSFSTFPMASPGSLGEPFPTNKTSIRQGGEEAISQVESHPALMKGLKRKEDQDRSPRRHCHEAAEDSDPLSRGDHPPDKRPVRLNRPRGGTLFGRTIQEVFKSNKEAGRLGSKESKKDSGFVESGESDHVAIPGGSQSTLVTSRLPAVNKEEETEGRDEKEDSLRGTSVRQSKRSESTDSLGGMSSLELTAIQCKNIPDYLNDRAILEKHFSKIAKVQRVFTRRSKKLAVIHFFDHASAALARKKGKGLHKDMAIFWHKKKISPSKKPFSLKEKQLGEGEASQGIEDSPFQHSPLGKPIVRPATGSLLNKSSPVKKPGLLKIHQFEADPFDSGSEGSEGLGSCVSSLSTLIGTVADTSEEKYRLLDQRDRIMRQARVKRTDLDKARAFVGTCPDMCPEKERYLRETRSQLSVFEVVPGTDQVDHAAAVKEYSRSSADQEEPLPHELRPSAVLSRTMDYLVTQIMDQKEGSLRDWYDFVWNRTRGIRKDITQQHLCDPLTVSLIEKCTRFHIHCAHFMCEEPMSSFDAKINNENMTKCLQSLKEMYQDLRNKGVFCASEAEFQGYNVLLNLNKGDILREVQQFHPDVRNSPEVDFAVQAFAALNSNNFVRFFKLVQSASYLNACLLHCYFNQIRKDALRALNVAYTVSTQRSTVFPLDGVVRMLLFRDCEEATSFLNYHGLTVADGCVELNRSAFLEPEGLYKARKSVFIGRKLTVSVGEVVNGGPLPPVPRHTPVCSFNSQNKYVGESLATELPISAQRSGGDSAGGGRGEEVEAEVDVPPLAVLPQLPPAPSATPVPHVQPLTQAVTPSLFQASTQPEVLLPKPVPVYSDSDLVQVVDELIQEALQVDCEEVSSAGAAYVAAALGVSNAAVEDLITAATTGILRHVAAEEVSMERQRVEEEKRRAEEERLKQERELMLTQLSKGLAAELTELTVTECVWETCSQELKSAVETDQKVRVARCCEAVCTHLVDLFLAEEIFQTAKETLQELQCFCKYLQRWRGAVAARKKLRRQMRAFPAAPCCVDVNDRLQALVPSAECPITEENLAKGLLDLGHAGKVGISCTRLRRLRNKTAHQMKVQHFHQQLLSNAAWAPLDLPSFVAEHLPVKQKRIFWKLVLVLPDGEEQTPESPGRILENWLKVKFTGDGSLVDDTRDNAGDIQTLSVFNTLSSKGDQTVSVNVCIKVARGTLSDSALDAVETRKDLLGASGLMLLLPPKVKSEDVAEEDLYWLSALLQLKQLLQAKPFQPALPLVVLVPSSRGDSTGKGVEDGLMLQDLISAKLISDYIVVEIPDFVNDLHGTVKVSGAVQWLISRCPQALDLCCQTLIQYVEDGISREFSGRFFHDRRERRLGSLASQEPSAIIELFNSVLQFLASVVSSEQLGDISWPVTEFAEVGGSQLLPHLHWNSPEHLAWLKQAVLGFQLPQMDLPPPAALWLPVCSMVIQYTSQIPSSCRTQPVLRSQVESLLCRTYQKWKSKSLCPGQQSGPSVAEIPWDDIITLCINHKLRDWTPPRLPVTLDALSEDGQICVYFFKNRLRKYTVPLSWEQARMQTQRELQLSQGCSGIKSFHPTSSFPTPLLHGRHKGKKKEDGGREGSLSTEDLLRGASAEELLAQCLNNSLLEEREENKRFEDQLQQWLSRDSQAFTESARLPLYLPQTLVSYPDAIKTQTKVKTSTSPQNAGTGDHVRFSEASDTSLTEKLKHLERLIQSSRAEEAASELHLSALLDMVDI
The following text describes a protein:
Function:
Involved in the biosynthesis of cis-abienol, a labdane diterpene that can be used as synthesis precursor of ambergris substitution fragance products.
Miscellaneous:
MISCELLANEOUS: The expression of both CPS2 and ABS is necessary and sufficient to catalyze the biosynthesis of cis-abienol from geranylgeranyl diphosphate in a heterologous system.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MVLGLRSKIIPLPDHKLGNIKLGSVTNAICHRPCRVRCSHSTASSMEEAKERIRETFGKIELSPSSYDTAWVAMVPSRYSMNQPCFPQCLDWILENQREDGSWGLNPSHPLLVKDSLSSTLASLLALRKWRIGDNQVQRGLGFIETHGWAVDNKDQISPLGFEIIFPCMINYAEKLNLDLPLDPNLVNMMLCERELTIERALKNEFEGNMANVEYFAEGLGELCHWKEMMLRQRHNGSLFDSPATTAAALIYHQYDEKCFGYLNSILKLHDNWVPTICPTKIHSNLFLVDALQNLGVDRYFKTEVKRVLDEIYRLWLEKNEEIFSDVAHCAMAFRLLRMNNYEVSSEELEGFVDQEHFFTTSSGKLMNHVAILELHRASQVAIHERKDHILDKISTWTRNFMEQKLLDKHIPDRSKKEMEFAMRKFYGTFDRVETRRYIESYKMDSFKILKAAYRSSGINNIDLLKFSEHDFNLCQTRHKEELQQMKRWFTDCKLEQVGLSQQYLYTSYFIIAAILFEPEYADARLAYAKYAIIITAVDDFFDCFICKEELQNIIELVERWEGYSTVGFRSERVRIFFLALYKMVEEIAAKAETKQGRCVKDHLINLWIDMLKCMLVELDLWKIKSTTPSIEEYLSVACVTIGVPCFVLTSLYLLGPKLSKDVIESSEVSALCNCTAAVARLINDIHSYKREQAESSTNMVSILITQSQGTISEEEAIRQIKEMMESKRRELLGMVLQNKESQLPQVCKDLFWTTINAAYSIHTHGDGYRFPEEFKNHINDVIYKPLNQYSP
The following text describes a protein:
Function:
Catalyzes the formation of undecaprenyl-PP-N-acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to the peptidoglycan of B.subtilis; may also be involved in teichuronic acid biosynthesis (Probable).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRKVHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAKVKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDGLDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTGSLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDKSHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIAEVTGLVNEKFKPFTKFYKRLVKRN
The following text describes a protein:
Function:
Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAEQKSSNGGGGGGDVVINVPVEEASRRSKEMASPESEKGVPFSKSPSPEISKLVGSPNKPPRAPNQNNVGLTQRKSFARSVYSKPKSRFVDPSCPVDTSILEEEVREQLGAGFSFSRASPNNKSNRSVGSPAPVTPSKVVVEKDEDEEIYKKVKLNREMRSKISTLALIESAFFVVILSALVASLTINVLKHHTFWGLEVWKWCVLVMVIFSGMLVTNWFMRLIVFLIETNFLLRRKVLYFVHGLKKSVQVFIWLCLILVAWILLFNHDVKRSPAATKVLKCITRTLISILTGAFFWLVKTLLLKILAANFNVNNFFDRIQDSVFHQYVLQTLSGLPLMEEAERVGREPSTGHLSFATVVKKGTVKEKKVIDMGKVHKMKREKVSAWTMRVLMEAVRTSGLSTISDTLDETAYGEGKEQADREITSEMEALAAAYHVFRNVAQPFFNYIEEEDLLRFMIKEEVDLVFPLFDGAAETGRITRKAFTEWVVKVYTSRRALAHSLNDTKTAVKQLNKLVTAILMVVTVVIWLLLLEVATTKVLLFFSTQLVALAFIIGSTCKNLFESIVFVFVMHPYDVGDRCVVDGVAMLVEEMNLLTTVFLKLNNEKVYYPNAVLATKPISNYFRSPNMGETVEFSISFSTPVSKIAHLKERIAEYLEQNPQHWAPVHSVVVKEIENMNKLKMALYSDHTITFQENRERNLRRTELSLAIKRMLEDLHIDYTLLPQDINLTKKN
The following text describes a protein:
Function:
Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk.
Subcellular Localization:
Secreted.
Sequence:
MLRHLLRHENNKVFVLILLYCVLVSILKLCTAQPDSSVAATDNDITHLGDDCQVTPVIHVLQYPGCVPKPIPSFACVGRCASYIQVSGSKIWQMERSCMCCQESGEREAAVSLFCPKVKPGERKFKKVLTKAPLECMCRPCTSIEESGIIPQEIAGYSDEGPLNNHFRRIALQ
The following text describes a protein:
Function:
Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton (By similarity). Plays a central role in renal ciliogenesis and kidney development.
Subcellular Localization:
Cytoplasm. Golgi apparatus, Golgi stack. Cytoplasm, cytoskeleton. Synapse. Cell junction.
Sequence:
MEAGSVVRAVFEFLPSVSEELPLFTGDVIEVLSVVDEFWLLGNKDGVTGQFPTTFVESVTIPGTKAGENLYVCINDFNSAEAGNLPLKRGDVVAAESSMDSVWMRGHNAWGSRGLFPVSCIKELELSGRSRQLSERSAAVQASELPPHALGQARALMNLHAQLDEELDFREGDVITIIGLPEPGWFQGELDNRTGLFPEGFVELLGPLRSPLEEPEPQTLEQYPDYSNEDEERRAEEEKDEEPPEMEIQQCQEDEEEEEGAIYGIALYEFRALEPGELDFDVGDRIRILASMDDGWLEGQIHSRRGVFPHRFVKIEGQLQTVPQTETLINEISVPKREEECYTPDYTSAEEDHTVPEYGQELSIQQDHTVWDLDYFERREEEQKENNGHNVHSDQSSQERRMTQNQSQVQPQERRRDRPPPPQTQPNRGSSSAHRSVQINRRSSPNMGRPQLPPRPSLHALSNRKYSTGSHASLRQPPPAPITMNQSLNPPNKTSPNSTWTRNNGKYASYNSRNPLSSKSSGEKNRQKKLTRHASVNDADIISGGSSEQQAWPQVQGSNGFPTSQTMGTLALSAKDLEAKLSQQLIEFEKSLPSHSNEATEQSRWEEVSGRLGNKVSRHFSIMDYSDENDIIRGSSHSSIERLLPSTSSPSGSASSSLERRKNLRPPPPRPRVLRPPAPTNTHWSQTNGRITPQPYRPARPAPRPPPPCPHTNAVTPPTTSNPFYNSPDEEEIVEEMEEPEDVLEAEKEMEREQEQYRLLLRLEEVEREIDMYSNTAQELQAMLDEEQDETSRQQALENLEFCSYTMETLTLEQQQLQEMTLLASQPKSLESSPASAANSEDPELRMLEKRTKVIEELLQTEHDYIKDLQMCVKEIIQPLQKKQVQGIDFDGLFGNISSVIDLSRRLNKTLQDTDSIGQVFLSYKDQLEDVYKIYCQNHDDAISLLETYEKDENIQKHVLECLEKLRGIYREWGKTNYINLGSFLIKPVQRVMRYPLLLMELLNTTPESHHDRQQLSEAVMSIKEINVNINEYKRRKDLVVKYRKGDEDRLIDKISKLSMHSIIKKSNRVSSHLKHLTGISPQIKDEAFDDAEKRFRLQERLIKSFIRNISLYLQHIRESASVKVLAAISFCDIYTERQQQMDPERFQRAHRCISDKQFTEFKERTEALVITPLTQLLNMFTGPHKLIQKRRDKLLDYDNCKERAERLKDKRVQEELQTARNNYEALNAQLLDELPKFHRAAEDLFTSCVRGFVQAQRDFISLTLGELTPLLQLSGLGGTEGNLVSLFQEEHTRVLDLLQSFSFFPENLPTTVRKTFEKKTLEKQYTKKPQAPPNYVLQTDEHRAGLLVRYGPENLYQAERNFNAAQDLDVSVLEGDIVGVIKQQDPMGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSQSDVSIESQSSNESGYGGSSPMFSRQNSNSTLTFNQETSTVSFTTATTQNQSNTRPNNESTPRKIRETSSNQRDSLEPGFRNSPNHKEVSETAIRNSREYSEPSHRSSTNHRDSVDSDQNTPTNSRDRLDLSETDSSSSRNSRYEPSSRYQDSKASYGSHQRQNGDYSGQQRRPQYTPEEYIEPEPEPEIDGHQIYYALYSFSARCANELSISANQRVRILEFQDMNGNQEWWLGEAGGRRGYVPSNYIRKSEYT
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MISTHLAPPFQYYAPNPVAPPIPTLDEKYKPFPHYNLEVVQWSLIFGVCLILGVGMGANDIADSFGTSVGTGILTVTQAFILATVVEMMGSVASGFSGDGQQLQVVNTESYEDNPDELVIGQIAMLVGCATWLMVATFYSMPVSAIHSLLGATIGFSLVLRGLDGIVWDRVGMVMAVWILSPIVSAIFTLITFFLVDVAILRAKNPVKRGIFLLPGIYAIVVFSNVFLFLQDGSKVFRIDEIPFLYTVAASLIIAVLAGFLALFVVGPIMQRKLKKKTEKLPRIASSLSYTFPIVPRGWLRRAVYWAFPPMRNDDQKAVRLFSFLQILTACFAGFAHGANDISNCVGPVRDLVHMYNEGYREDNTKLNITVYILLLTTLAVVMGIWTLGVRVIRTVGKFSKMNPATGFSVQFGAAITALVNNMYNIPESGTHCLVGSIFGLGLVRSGPILEWHTVKYVFVSWILTIPGSGLISAAVMYLLQAVLG
The following text describes a protein:
Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSSGEPLAADEVTCTSASEGLEEGEVEGETLLIVESEDQGSVDLSHDQSGDSLTSDLGEEGEGGWACEDMSFYCERCHKWTPAAQLRGEQPSYLKGDNFFKFTCCSCSEDGKESFERMRLTWQQVVMLAMYNLSLEGTGRQGYFRWKEDICAFIGRHWNFLLGTKKTSTWWSTVAGCLSVGSPTFFRSGAQEFGEPGWWKLVQNRPPTLRPDVDKSAAKTKASKPVLDPIITVEGLRKRGARNAVENAMQLKEKRSRTQEAKDIRRAQKEAVGGYPDRSASSTPVKLGGGRGGGAGRRPDLVLEKGEVIDFSSLSSSDRTPLTSRSPSPSPDFSAPGTPASQSATPSLLSEADLIPDVMPPQALFHDEEVDGMIDPGMEYAPPPSATLIGRKKVCSAPPHIKREADSEEDDCPERHEDFEESGGRKEAPPSPSGGAERRRAPAAADIVASPRCVAVSLYEERLLLRRLDACPLALAVTPQARRLRRKLLVRQAKRQRGLPLLDVDRAISATLSLVGGIYGGSEGGPNAGGGAEEKYRTSSRELQILDRFQTRTSGRRGVPLHSVSFWHRLMGAEGGLEQSIKSPYTSRVLKRDYESRPLKLRLLAEIRAYPHRKDPAWVPEADAPIDYCYVRPNHIPSVNAMCHHGFWPVDLSECLQYPDFSVVVLYKKVVVGFGFMVPDVKYNEAYISFLLVHPEWRRAGIGTFMIYHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKAEEYILDFYDKFYPVDSAECRHAFFLRLRR