lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May organize microtubules by mediating spindle positioning and movement in the budding process. Required for cytokinesis and the maintenance of polarized hyphal growth.
Subcellular Localization:
Bud neck. Cell septum. Note=Localizes only at septal sites in both yeast and hyphal stages.
Sequence:
MNEPPPKRQSVFAKGMKKLQRSKSLLNFAEQAKPPTPENFSSLDPKSNLNSIGLSLVGYGLSSDHLPPPRLDTDSESVSSRTSSPTLHVTTKFNPKQRVESFQTATNFKNQIPPEEIVDQLFEKLLSIRVFPDEAVYSLKKQPVERKWELLLREHETNHHFDLKKLSEQATDKFLTNRDRFQEHEFLIMSRSTTQEPKPKLKPLRIVSGGEDYDDEETPTVTKLVHDDSSTSKLSIESGGSSGAPTETESLLGLVNKKLKIRDGSPDWYVSRIMANKLSLKDCKKLERKLVENNVVKNSGVTWTQGFINAQGETALSVVLTKINKKSIKSNEEFDKEYLIVKCLKHINSEKRDETSSLKEKVYVVKALVFLLVSPRLTTRILVTEVLVMLMLLRDKTLWKSALDGLSSLQDRNGDYVIFQPWLNAFEETIIKYSWSQNKAGELSNLKNYATITLILINSMVDMCSSLKRRISIRRDFGNARILNIFEKLAQIEDTRIDNEIEKYEMYAEEDYNEYVEGKKKRNSKQLPNIPQSKLKLLQVSDFVTTPEANTSLEEDELTPELEDNLSGTESSFDEKSFMTKLKEAEDIESDGAMKSVLQRLMKLKQSERSTEDVHKMLVLVDSMLQHVTNESRVIGTDAHSVLNITIQKLMDRLSTEDMARRAVAESKMLSRQLELVKEEKELLEKELETNKIETIRELKKENYYQAELIATQERQLSKLQQKIEQLQSPNNTALPVVDVGQQGFGNGTVASLKDTSSSSPSKRPPTPPGLYSMQKGSLRGGISAPPMLDFKDARPVSDLQDSRPVSDLQDAPRLVESSAPPLPESKDPVAQPPPPESKDSVAPPPPPVPDFIKSAAPPPPPLPGFMNASAPPPPPVPEFIKSSAPPPPPLPGFITTTPPPPPPLPGFITTTPPPPPMPGMLQPGKVKELGTLFKEKHKQEPQKGITKTKADVVPSIRPKNKLKQMHWDKLENIEKTFWNNLEDSVLSNKLIEQGVLGEVEQVFAAKTATIKKKTAVESQQQPTKKSFLSRDLSQQFGINLHMFANLSEEKLVLKVLRCNSEILENHSVLEFFNNEALVELSDSLFRNLAPYSTDPRTRKKPMKNPEELERADRIFLELCYNLRHYWRSRSRALLFSQTYKKDYIDLMRKLNIVDEANAALKKSESLQNVLGIIRTVGNFMNDDAKQALGFKLDTLQRLKFMKDDQNSMTFLHYIEKIVRHSFPEYGSFVDDLNVLSTLHNISIEQLETDCEEMSRSVKNITDSLERGKLSNKKDLHPEDRILTTISSPMLNAKNKNAMLQSHLKRTAGELNSLMTFFGENPKDATARNTFFYKFVTFITEYKKAHVENIQREEEQRTYEIRKKILEDKIAKKEKLKEESAEPEAVVDTAEESSAVIDSLLEKLKSSTPITTNRAKTKNRRSKALSFYSENPLEIVADTKYESVNNLKRRMTTRKRTTDGETSPKSEQFMSRAQAMLHQLRNKEE
The following text describes a protein:
Function:
Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKDSWSSNSTTSTAIRLVGSPYGTDSPFQPTFTYPIYGEAETIYGYEGLAIKLSVASGSLVPLLEVTYRAKNEATTAEIDDVEGKIKEFLAPDFLSTSSPSAMEEFETVVKADKEFRPLGDKVHSYTRGKVDKGKAKSSTASLASSTLSASDPNARVFEIYRSTWHTPGFREYHRRMQLFTLLFIEGASYIQEDETNWEFFTLYEKVSRDDKQTWHFMGYTSLYKFWCWPDSSRIRLSQFVILPPFQKQGHGGALYTTVYDQIRERANVTELTVEDPSEDFDRLRDGNDLRRLLAPGGFADSAKAQNKLHAPLDKEWIESQRLQHKLAPRQWSRVLEMVQLMNLDTTDHEQVKQYRLQVKARIYRQNKDILMQLEKQQQRSKLQETFEGVVEEYGDMVGVDVEDLLDDGPSGTGALYGADEEEDQEQGQGDRHYSNGNGPPRKMARLA
The following text describes a protein:
Function:
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLPFLAAAGHDPTDHAIPHALHDSPLLKIPFGGEDTNVPALGIRDGYYEFFLTNHLMMTAVVGLLLIITGVLCSRKISIFHGEGLGRYQTRGRLSQLFETICAFIRDEVAYPNLHGLTDKYIHYIWTVFFFILFANILGVIPFGYMLQLITGNDAFSHWGGSATGNLSLTSMLALTSLIAIIFIGIRETSAKDFFNHFNPIGWDGGILMLPIALMLYVLEWLSLLVKCFVLAMRLFGTMMAGHLVLAAFVGLIFAAGEASKGMGYAVSVPVVLVATSLTLLELFVCCLQAFIFTFLTVLFIAAMATHEHDEHLDDDPHAMTDANQMDPDKIFDPSRISPAVGASHPAGV
The following text describes a protein:
Function:
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MSSFPELYFNVDNGYLEGLVRGFKAGVLSQQDYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDKLKEKMVMEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGKLYPEGLAQLARADDYEQVKTVADYYQEYKLLFEGAGNNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF
The following text describes a protein:
Function:
In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes. Plays a role in stress granule formation.
Subcellular Localization:
Cytoplasm, Stress granule. Nucleus speckle.
Sequence:
MSAAFPGASLYLPMAQSVAVGPLGSTIPMAYYPVGPIYPPGSTVLVEGGYDAGARFGAGATAGNIPPPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW
The following text describes a protein:
Function:
Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
Subcellular Localization:
Nucleus.
Sequence:
MGPVMPPSKKPESSGVSVASGLSQFYQASSITRALQEAEEMDLALPTIKLEKGSVEDEELTNLNWLHESKNLLNSFGDPVLRSVSPVQDLDDDTPPSPAHSDLPYDAKQNPNCKPPYSFSCLIFMAIEDAPSKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPYSQVFTTPPTSPQAYQSMSSPPIWPGSPFYRKNKGVLLQVPQGVIQNGARMMSQGLFPGIRPLPINPIVSRTAAVRSVLGYRITSDTEPTQNSPLATSDPKEDHTYSFAKSSGSDAEEEAQCDGSELNFHTNETGSDAEDDDKSKIKKEPKEWSVDALALAQHKKRQLLTKVKQRVASDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGVRACLNNITNRTAKGQKEQK
The following text describes a protein:
Function:
Has a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MQTPRTPTINFGPTGGSGSPGGGTAFFGRSDPNAMMLQMGLSYGQNILQKHVQQGEAGLAYYMPFIRAIRNYFAVDNTYVKRKLIMLTMPFLTKYVRKSPVGGESDFGSTGGGAGEATGDQVFGGPAGSPASMYPAVLSSTLAGHDGGGSTFAGPLLPLNDVFASDLYIPLMSVITYVVLAAYIFGANSPTSSVTAASLISTAWVIGIWFFLEVVVLKGVAYALLVAPNPPLLELLALCGYKYVLLCLGLLASQCLPPSRLYSGLFMLYAVLAHSFFTVRVSGMQYMRNDGRVPPRPRVFTYMAALAQVPGSVWLFVRLL
The following text describes a protein:
Function:
Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase.
Sequence:
MGSKKILLVEDDPNFGTILKDYLALHDYNITHAKDGIEGLIEFKNNDFDLCILDVMMPRKDGFSLAADIRATNKEIPIIFLTAKTMKEDVLKGYQAGADDYLNKPFDSEVLLFKIKAILQRKETDKSKESDEFEFTIGKFFFNSKLRHLSYQDNEPQKLSPKESKLLKMLAVHKNDLMPRELALTKIW
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular Localization:
Nucleus.
Sequence:
MAPKRKPAVAAERDPDGIFRGVSAFIVPHGVQARRLEVWKQRLVQMGGRVVEKPPKGELAGFNHVLAMDAKALLRELDAAWLHRFRGSVVSFEWMEECLKSGERLPNHKFAINYEEELKPKNAVGTENLGALQPAKRTKMSSEYPGDCQRVSGGDRESELAAAGSPGASAHMVEGSSAGKQPNQYASSQSSSADSKDTVGSHGTFGIEEASSGGPSIYAPADLNRNITKIFGRLIDIYRALGDDRRSFSYYKAIPVIEKLPFKIESADQVKGLPTIGKSLKDHINEIVTTGKLSKLEHFENDEKVRTISLFGEVWGVGPATALKLYEKGHRTLDDLRKDESLTNAQRIGLKFFDDIKQRIPRHEVSEMEELLKDVGTDILPGVIIVCGGSYRRGKASCGDMDIIITHPDGESHVGFLPKFVQRLKEINFLREDLIFSIHSVDGSDSGVDTYFGLCTYPGRELRHRIDLKVYPRNRYACGLLAWTGNDVLNRRLRLLADSKGYVLDDTGLYLATRGSGGKHAGRSDAIVNCDTEKDVFETLGFPWLEPHERNL
The following text describes a protein:
Function:
May act as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus speckle.
Sequence:
MKLIKKLLEDEEDSFFKNKIVFKNFVIKKVFKKYLQFINVTTGNNENSSVDLQSLCTQLINEFGHLELSVQKAQTISETCTDETLYYQQLSKQREIEIENEKKEIAILKETLDYEKKQRQYKEQYLALYKAINEKPSTEQTEKEIEKAQKELNEITDQTNKTTSKLELRTKQFQLLLHTLNELEKNLDESIPFIENSNNNNNNSNSDQSNTPMES
The following text describes a protein:
Function:
Inhibitor of serine proteases chymotrypsin, papain and trypsin. Has strong antifungal activity against C.albicans and R.solani. Has antibacterial activity against the Gram-positive bacterium C.michiganense, but lacks antibacterial activity against the Gram-positive bacterium S.aureus. Lacks hemolytic activity against human erythrocytes.
Sequence:
DICTNCCAGTKGCNTTSANGAFICEGQSDPKKPKACPLNCDPHIAYA
The following text describes a protein:
Function:
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions.
Subcellular Localization:
Cell projection, cilium membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MLNDHLVTIQLFLFLQIKTLNPLSKQLFQNTGPLRTVHFKISSFLNSSGSAQHTMSAYPKNYNPFDDDVDDEDLKPVKWKNEEDFSDKPREPLDRQQYLRQEVLRRTEASVESTNRSLSSIYESEKVGIASSEELVRQRGVLQRTEQMVDKMDQDLKTSQRHINNIKSMFGGLVNYFKSKPADATHPQNGVADSQPNTRLKEAIVTSKEQEENYQASHPNLRRLQSSDAIMGGTSSSLSTDGYPKNQHLRAYHQKIDSNLDEMSKGLGRLKDIALGMQTEIEEQDDIIDRLNTKVDKLDINIKSTDKKVRQL
The following text describes a protein:
Function:
This protein is a positive regulator for the gene expression of the galactose-induced genes such as GAL1, GAL2, GAL7, GAL10, and MEL1 which code for the enzymes used to convert galactose to glucose. It recognizes a 17 base pair sequence in (5'-CGGRNNRCYNYNCNCCG-3') the upstream activating sequence (UAS-G) of these genes.
Miscellaneous:
MISCELLANEOUS: Present with 166 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif (residues 862 to 870) is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSIDSAAHHDNSTIPLDFMPRDALHGFDWSEEDDMSDGLPFLKTDPNNNGFFGDGSLLCILRSIGFKPENYTNSNVNRLPTMITDRYTLASRSTTSRLLQSYLNNFHPYCPIVHSPTLMMLYNNQIEIASKDQWQILFNCILAIGAWCIEGESTDIDVFYYQNAKSHLTSKVFESGSIILVTALHLLSRYTQWRQKTNTSYNFHSFSIRMAISLGLNRDLPSSFSDSSILEQRRRIWWSVYSWEIQLSLLYGRSIQLSQNTISFPSSVDDVQRTTTGPTIYHGIIETARLLQVFTKIYELDKTVTAEKSPICAKKCLMICNEIEEVSRQAPKFLQMDISTTALTNLLKEHPWLSFTRFELKWKQLSLIIYVLRDFFTNFTQKKSQLEQDQNDHQSYEVKRCSIMLSDAAQRTVMSVSSYMDNHNVTPYFAWNCSYYLFNAVLVPIKTLLSNSKSNAENNETAQLLQQINTVLMLLKKLATFKIQTCEKYIQVLEEVCAPFLLSQCAIPLPHISYNNSNGSAIKNIVGSATIAQYPTLPEENVNNISVKYVSPGSVGPSPVPLKSGASFSDLVKLLSNRPPSRNSPVTIPRSTPSHRSVTPFLGQQQQLQSLVPLTPSALFGGANFNQSGNIADSSLSFTFTNSSNGPNLITTQTNSQALSQPIASSNVHDNFMNNEITASKIDDGNNSKPLSPGWTDQTAYNAFGITTGMFNTTTMDDVYNYLFDDEDTPPNPKKE
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB17 (By similarity).
Sequence:
MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVVRPGFQACELSRGR
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Sequence:
MAEVAETAQPLLERATADELKHYYYQMLLLRRFEERAGEMYVKAKIGGYCHLNLGEEATIVGLMAALTPDDYIFTNYREHGYIIARGVPPGPVMAELFGKETGVSGGRGGSMHLFDRKTNFMGGYAIVGGQVPLAVGAAYALRYQNKPGVVVAQMGDGTTNIGAFYESLNLAKLWKCPVLFFIVNNGYGMGTSVEAGSSEPDLWKKGASFRIHGERVDGTDVLAVRDVVRRLRARAEAEGEPAIIDAVSFRFRGHSVIDSDRYRDPEAVRRGRELYDPIRKFATLLLDHGVVDDAWLKGIAEQVEREVQEAIDFANNSPDPKFEDLYKYMYATPVPNTPTAEDAIRAVKINRGEFDV
The following text describes a protein:
Function:
May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton. Note=When overexpressed, localizes to the cytoplasm where it associates with acetylated alpha-tubulin.
Sequence:
MDGQALRKVERSRSCSQERKEGYSKDMVTDFDEKHDEYLILLQQRNRILKHLKAKDPVQLRLEHLEQGFSVYVNGANSELKTSPRKAVHTDFSRSASQAEGSQDYGRRTLFREAEEVLRRSSRTAPGKVQRRGWHQKSVQIRTEAGSRLHIEPPLDCSEDFESQEDVIGKHEDATGEHTQELRKGLGLSTSLQTQEDGSSDEYDSIEEDVLSETETEDPVLPVHNRDECPLPSHDAVQKDVPKDQELEGRHPQATDTLVVMEFNPASKGNKMDRILSAKRKENAEVFIPSKPDSVLNPQPPAVFPEQERACSRSGSRRDRPLSATRKAYAAEDREEDASAVLKAIQVENEALQQVFLSHDPELHTSPQQDTKEPPAKSWSSLLKAKEDIPELLPATPVTTDPELCRAAAGAKAVSQAMDGMSPLGSRQQHKLVGVLQTMESDTTHLSQVAIPTEKPVPNSEEKWKARVDEIEDAIYVTMEILSNWGNASWVGLTEVQFFDLNNIKLYVSPHDVDIRNAVLPGELGCLVNRDLVSKKDPPVWTCPFHPPLQLYFIIHNMRQLRDFGLTMIKVRNYWTADGDLDIGAKNVKLYVNKSLIFDGVLEKGGGEAPSDCTIPVDLQRERNESSDKALSTGWKESKGALKMAALSDARELGLSCSQPAESLDMTVSSQGDFLGEKVNSTSGLKNSLSKLQEDVRLLATPASMGDGPSVPSSSSPGKCLPLEEEPSLIQQLESLRGRKIPEPTGKTPHWLQPSLAGMGKKQTVRKPKPLWLSPEKDLEQKSRFPSEDVMGDTPGEVETREKGPRREQGRTSSWNVITEERAPKAFSKACGDDLDIFSQLPNRDRPASGRRALKKEASSSHGDDRPASKEDTQASQTLPWLQWYGEQEHALHASWDSLTAFDRAHRGRISALEPQGDILDEFLKQQRSSRHEEFPAPCREEEPEPSTEMGGDSDFKIPVLPYGQHLVIDIKSTWGDRHYVGLNGIEIFSSSGEPVQISSITADPPDINILPAYGKDPRVVSNLIDGVNRTQDDMHVWLAPFTPGMTHTISIEFTHPCQVALIRIWNYNKSRIHSFRGVKDITMLLDTQCIFEGEIAKASGTLMGAPEHFGDTILFTMDEDILEAIFCLDDTFDMDAESLCGLQPEEALRRPSTADGEGQDERPFTQAGLGAQDQVPGLELQTSPPVSEVTTPEPGIFYGLCLRLNLTASWGDLHYIGLTGLEVVGKDGEALPIQPHQLSASPRDLNDLPEYNDDSRTLDKLIDGMNITTEDEHMWLIPFSPGLDHVVMIHFDRAQSIAGLRLWNYNKSPEDTYRGVKIAHVSLDGLCVSPAEGFLIRKGPGNCHFDFAQEILFGDYLQTRLPPAPTRRLDAKSLERASMDYEAPLMPCGFIFQFQLLSSWGDPYYIGLTGLELYDEHGERIPLSQNNIAAFPDSVNALEGVCGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYTKTPQRGVKEFGLLVDDLLVYNGILAMVSHLVGGILPTCEPTVPHHTILFAEDTDFCHQEKHAIISKPEEDQDIQMMNENQVITTSRRKPGTADPALRPKTCIREKETSRRWRC
The following text describes a protein:
Function:
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MPKGRQKVQPWSAALEPSLGLPACLWLVVTGFLLLVPLVMTLELTETVGPKAQGPRGLSWAVLLDRMEGEGKEESEEQQADALAQAAGLLNAGRIGELQGHYLFIQPPGHIGVQQEEAARKQAEAVFSRHEAVRWHSEQRLLKRAKRSVLFNDPKYPLQWHLNNRRIRGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIEPNYCPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSKIAGIRVLDGPLTDSLEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRRGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGHMPFYAEECASMLAVTFSGGDKLLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATQYEDRCADWDTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYTSPMLKENKRIPVSPNFLEVLWNVSKSDLEMSGLRTLEHVAVTVSITHPRRGSLEQKLFCPSGMMSLIGAPRIMDTDPNGFNDWTFSTVRCWGERAQGTYRLVISDVGDELLQAGILQQWQLTLYGSVWSLTDIKDRQRQLEDAMSGKYLHDGFSLPCPPGLEIPEVEGYTMTPNTLKTLMLLGCFAVFWTIYYLLEVYLSQRDVTFDVACGRGHCWWLQRSRKAMEEGTELESVPLYNGKDVSEADTESEDHSSTSGLQAPDLLDQGNWGLIEDIEKPSESSRRNPPPDLLQGEQEQQAC
The following text describes a protein:
Function:
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Binds to the URS1 site (5'-AGCCGCCGA-3') and recruits the RPD3 histone deacetylase complex to the promoters to negatively regulate the expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. Also recruits the ISW2 chromatin remodeling complex to promoters in a second gene repression pathway. Associates with the master regulator of meiosis IME1 in order to activate the expression of meiosis genes. Has both a positive and negative role in regulating phospholipid biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 217 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MLDKARSQSKHMDESNAAASLLSMETTANNHHYLHNKTSRATLMNSSQDGKKHAEDEVSDGANSRHPTISSASIESLKTTYDENPLLSIMKSTCAPNNTPVHTPSGSPSLKVQSGGDIKDDPKENDTTTTTNTTLQDRRDSDNAVHAAASPLAPSNTPSDPKSLCNGHVAQATDPQISGAIQPQYTATNEDVFPYSSTSTNSNTATTTIVAGAKKKIHLPPPQAPAVSSPGTTAAGSGAGTGSGIRSRTGSDLPLIITSANKNNGKTTNSPMSILSRNNSTNNNDNNSIQSSDSRESSNNNEIGGYLRGGTKRGGSPSNDSQVQHNVHDDQCAVGVAPRNFYFNKDREITDPNVKLDENESKINISFWLNSKYRDEAYSLNESSSNNASSNTDTPTNSRHANTSSSITSRNNFQHFRFNQIPSQPPTSASSFTSTNNNNPQRNNINRGEDPFATSSRPSTGFFYGDLPNRNNRNSPFHTNEQYIPPPPPKYINSKLDGLRSRLLLGPNSASSSTKLDDDLGTAAAVLSNMRSSPYRTHDKPISNVNDMNNTNALGVPASRPHSSSFPSKGVLRPILLRIHNSEQQPIFESNNSTAVFDEDQDQNQDLSPYHLNLNSKKVLDPTFESRTRQVTWNKNGKRIDRRLSAPEQQQQLEVPPLKKSRRSVGNARVASQTNSDYNSLGESSTSSAPSSPSLKASSGLAYTADYPNATSPDFAKSKGKNVKPKAKSKAKQSSKKRPNNTTSKSKANNSQESNNATSSTSQGTRSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYDAFKPDFVSDPKKKQMKLEEIKKKTKEAKRRAMKKK
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFSIPPPVIPAPATVVGRLQIVSVGASNFMEELDRIGLLLQMFPYVAIDTEYPGTLHGAPAGPALTTAARYYAFVKANVDELPALQLGLTLCDEGGKLPEAIDDYGRSLQLAWEFNFSDFDIARGRHAPESVQFLMSQGFHFDVAREYGVPSAYFADWLAGVLARLPHWCQPPTWVAFGGAFDFAYMVKMLSGGQPLPDTPEELVARARYLLRGSVFDAKCMAEHCGRPELCGAGLRTVAAVLGVPQLHPAPPRLAGPKSHTACRIYTVMRTLVHGGDGYAYAYEGLIDGIY
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MLILRKDSKFDRKSIEELKELAEVLYNPVKTIVQIRKADPKYQIGSGLVERIAENIKEENIEIVIVGNILTPSQKYNLAKKFKVEVIDKIELVLRIFYKHARTKEAQLQVRLAELQYELPRAREKVRLAKMGEQPGFGGYGDYEVEKYYQKVKREIATIKRKLEKLREHRRVARKGRAKFDTVGLIGYTNAGKTSLLNALTGENKESKNQVFTTLTTTTRAIKGIKRKILVTDTVGFIDDLPPFMIEAFLSTIEESADSDLILIVVDASDDIEEIKRKLKVNHEILSKINCKAPIITVFNKVDKITKEKKRKILEELDRYIVNPIFVSAKYDINMDLLKEMIIEHLNLSIGTIETDNPRLISYLYENTEIIEDILEDNKHIITFRAKERDVNRILKLHKSAV
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRQRRAKLYRKMLHAYQLQFGFREPYQLLIDDTFSLALSRYKISDPLNQFSNVLQSKKIKPLITQCCMQALYALGKQAQSTVDMAKQWERRMCNHRDAIDPQRCIKECVGDKNKHRYIVASEQGELRRDLRLGVAGLPMMHFTQAVMVLEPMSPLTKSKIEEKEEQKLSLPLSEAALLKSVPNVELDIVGAAANDAAETDAVEAGQAEANQEAGSRRRKRKAPNPLSVRKPKTPRLSMDDKLKREQELKKQKQRAAARARLQASSSNADNAQGATTHSARKKRRRSSTTKNRATETAQSGSSTPAPATDKKSQSEQKLVAAETNGQPRNKRRTRSHNAANNAKPVDGAPAEPVSA
The following text describes a protein:
Function:
Has antibacterial activity against Gram-positive bacterium S.pneumoniae Serotype 14. Is also active against Gram-negative bacteria M.catarrhalis 1857, and non-typeable H.influenzae strains 86-028NP and 1128. Has antifungal activity against C.albicans. May have a role in maintaining sterility in the middle ear. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity).
Subcellular Localization:
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles.
Sequence:
MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Sequence:
MEDAPPSLSCSDCQRHFPSLPELSRHRELLHPSSNKDSEEADSIPRPYRCQQCGRGYRHPGSLVNHRRTHETGLFPCTTCGKDFSNPMALKSHMRTHAPEGRRRHRPPRPKEATPRLQGETVSTDSWGQRLSSGEGWENQTKHTEETPDCESVPDSRAASGTWEDLPTRQREGLASQPDSEDAADGWGPSTNSARAPPLPTPASSLLSNLEQYLAESVVNFTAGQEPTQSPPAEEERRYKCSQCGKTYKHAGSLTNHRQSHTLGIYPCAICFKEFSNLMALKNHSRLHAQYRPYHCPHCPRAFRLPRELLEHQQSHEGERQEPPWEEKGMPTTNGHTDESSRDQLPSAQMLNGCAELSTSGELEDSGLEEYRPFRCGDCGRTYRHAGSLINHRKSHQTGVYPCSLCSKQLFNAAALKNHVRAHHRPRQGVGENGQPSVPPARLLLTETTHKEEEDPTTTLDHRPYKCSECGRAYRHRGSLVNHRHSHRTGEYQCSLCPRKYPNLMALRNHVRVHCKAARRSADIGAEGAPSHLKVELPPDPVEAEAAPHTDQDHVCKHEEEATDITPAADRTAAHTCSICGLLFEDPESLERHGLTHGAGEKENSRTETTVSPPRAFACRDCGKSYRHSGSLINHRQTHQTGDFSCGACAKHFHTMAAMKNHMRRHSRRRSRRHRKRAGGASGGGEAKLLAAGSWTRELEDNEGLDSPQDPSGESPHGAEGNLESDGGFLQAESEGDKCGLERDETHFQGDKESGGTGEGLERKDASLLDNLDIPGGEEGGGTRFCDGLTGVDEDQKPATGQPNSSSHSANTVTGWQAGATHTCSDCGHSFPHATGLLSHRPCHPPGIYQCSLCPKEFDSLPALRSHFQNHRPGEATSAQPFLCCLCGMIFPGRAGYRLHRRQAHSSSGMTEGEEEEGEEEGAAEAAPARSPPLQLSEAELLNQLQREVEALDSAGYGHICGCCGQTYDDLGSLERHHQSQSSGTAADKAPSPLGVAGDATEMVVGSVLEDIVTSVSGEGGDAKSQEGAGTPLGDGLCMQGGESLLEAQPRPFRCNQCGKTYRHGGSLVNHRKIHQTGDFLCPVCSRCYPNLAAYRNHLRNHPRCKGSEPQVGPIPEAGGSSELQVGPTPEGGSSKPQHMAEEGLGQAEVEKLQEKLKVEPLEEVAGVKEEVWEETTVKGEEIEPRLETAEKGCQTEASSERPFSCEVCGRSYKHAGSLINHRQSHQTGHFGCQACSKGFSNLMSLKNHRRIHADPRRFRCSECGKAFRLRKQLASHQRVHMERRGGGGTRKPTREDRPFRCGQCGRTYRHAGSLLNHRRSHETGQYSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRSAVRCALCGRGFPGRGSLERHLREHEEETEREPANGQGGLDGTASEANLAGSQGLEAQLGGAEPVPQLEDGVQRPGELSQSPIRAASSEAPEPLSWDAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSVHRSPCHAGDCQLNGPTLSHMDSWDNRDNSSQLQPGSHSSCSQCGKTYCQSGSLLNHNTHKTDRHYCLLCSKEFLNPVATKSHSHNHIDAHTFTCPDCGKAFESHQELASHLQAHALGHSQVPAQMEEARDPKARTGEDEVVLPGQGKAREAPSETPGSPGESVERARGGQVVTSMAAEDKERPFRCAQCGRSYRHAGSLLNHQKAHTTGLYPCSLCPKLLPNLLSLKNHSRIHTDPKRHCCSICGKAFRTAARLEGHGRVHAPREGPFTCPHCPRHFRRRISFVQHQQQHQEEWTVANSGAPVAPATGRGDLSLPPPPTPTTPLLDPSPQWPADLSFSL
The following text describes a protein:
Function:
May serve to lubricate the movement of the cellulose microfibrils during cell growth and wall extension and/or may serve to maintain the fluid state of the slug cell wall (By similarity). Overexpression shows aberrant stalk formation.
Subcellular Localization:
Secreted.
Sequence:
MRLLGSLILTLSLIASAFSSSVPLTLCMSGRAQGTESLNKSGSCEYGAYNGPTGPGTLTATLNEYFYSSGVKCGDCFEVSGPKGKTVVRVVNFCSAGTCPSERPLFMLTPDAFQEISSDPLSVVYDAGFRKVSCDASGPIKAQVSEDSSKYYVKLLIFNNEVGIQSVTIKGKDMSAPVTMVRQGSAQFVWSQAGKEMMFPATVVVSSQYGGSVTMTMNSLSMDILKFSGNFVAPKSSIIKNAPASCSLSASPLAIYQNGLTEGWNYWSSRSYSQINTTDSSSHSVGSTKSLSLVLMGSSSALTLARSGDFETTYFTGIKFNMKANTTMSGLRVYFPNEQNKYWTPSSPITTSWATYTVPFTSLQHKTIESAFTFANTENINVHINIDNIHFIASPSSVTTGYANGNETANSGLATTTVASGGSGASGVATSSHTGVSSSSSTASSTASSTASSIASSTASSSASSTSVSSTTAGGKTTSGGSGISTSGITGSGDSMAASTSKTTSNPTGKTTGMTGSSIDHSESHSSDEHHSSSSIIKASLLLVSAALAFASL
The following text describes a protein:
Function:
Plays an important role in membrane trafficking through the secretory apparatus.
Sequence:
MEVEVPGGSEAADTGSEASYKVSQVEIEDVEENLKNADVIFEHLEQLPFQVFILSEFGKPIFVNNDRNEGEIVSLVALICAFVSRCQSWGDSLMTMTSQDNHIQFLHKSPLIFCVVSKYPEQLDQQLEVLFEQICSILSKSQLENVYKKKGDNYDLRKLLRGTDRLIDSSISSWRASPINLVDSSISAIPMNPSDREFLSTTMASCLGAAKLDGALFGIMIARRQIAAMVRFKKYMIHPRDLNIVINLVSDNTLQTDSQNWVPICLPRFNDTGFFYAYISYPWCNKEQDIPVCIVLLSVKRDHFDGLKEVRQQIVTKLENNQKFFVNFAQAMKTPNLYQISQIGSNSESLWSFLYLNHSSKQVCMSASKIPLITRDERWIARSEMRRSSSLSSLHPHLRTLFVRGTKHCLFVWVTDLFSLYCIFGPFVTATIAFQVVEKLLKSLKSHEQRYFIINSTSF
The following text describes a protein:
Function:
Catalyzes the deacetylation of N-acetyl-L-citrulline to produce L-citrulline. This is a step in an alternative arginine biosynthesis pathway. Is also able to catalyze the deacetylation of N-acetylornithine in vitro, with almost equal velocity. However, this reaction may be not relevant in vivo since Xanthomonas does not possess the canonical argF gene and cannot convert ornithine to citrulline via ArgF'.
Domain:
Consists of two domains, a catalytic domain (formed by residues 1-166 and 286-365 from the N and C termini, respectively) and a dimerization domain (residues 167-285).
Sequence:
MTDLLASTLEHLETLVSFDTRNPPRAIAAEGGIFDYLRAQLPGFQVEVIDHGDGAVSLYAVRGTPKYLFNVHLDTVPDSPHWSADPHVMRRTEDRVIGLGVCDIKGAAAALVAAANAGDGDAAFLFSSDEEANDPRCIAAFLARGLPYDAVLVAEPTMSEAVLAHRGISSVLMRFAGRAGHASGKQDPAASALHQAMRWGGKALDHVESLAHARFGGLTGLRFNIGRVDGGIKANMIAPAAELRFGFRPLPSMDVDGLLATFAGFADPAAAHFEETFRGPSLPSGDIARAEERRLAARDVADALDLPIGNAVDFWTEASLFSAGGYTALVYGPGDIAQAHTADEFVTLAQLQRYVESVNRIINGSH