lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane.
Sequence:
MLSRIALKPVRSAIQPIRMTQTLATSNAASAATTESPERYLVNFPRPVCQEYPGKVRMGFIPDEWFQFFYSKTGVTDGNYIFVTLKSGPYTFGLGLATYLCSKEIYIMEHEFYTGLSIAIMGIYALKKLGPATAKFGIS
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MEDVSPFLCPPEENKNPKWDEIEGGLTISAKTEVQISSLRKLIQYSVSGEKIPEAALMGVITNLSASKNHDVKKLLYLFYEICETRDRKGNLKPEFRLICDGIRKDLTHPNEYIRAAALRFMSRFHEKELINTLVPFVTKSLDHHNAYVRRHAVVAIGRIHQRWPEIAPDAQEDIAELLKTEKDPACMRVSFLVLCDISRDLAATFLNEILDESVLHLSQPMQLTAVTLIKSLCNDSRKGAYLPALIELLDSPSTAVKIEAAITLLNLSTSATASQTSFSVLCQIMQTIPNSTLQLSLAEQIERLIPAHPSIAQLMVGELIVAMKSKGIRATVLNMIKKLTNATNVKTIVQGLINHYKTQELLRQKENEAKDAYEFMALILTTLRSISSTYPATLSMIYDAVKTTLIENNLAISYESLMLVRDYMFANPDQADRVCIQIENILPFVQSPRILRGLSYLISLSTTRPESAEAIIGAYFAREKAALDPETEQSAPQTSTMIGSDGTYVTVEQSAAPSKSGSKHLIWFEKGINIFVGASLAMVLARICIRFPDQAPIEKCLGFIESILLRKNAVTQEKHLLLAHAAIFHRNDPEYKIALLDNVKHAFADIIDNDKKEFEDKSPKANQKIFTSPDQRLSFSSLLGRKFDQAGPAAANAKNASLKIQEETQEEKSKKSLVVLSGTCDPIFSECTMKPGKFDILLEINLLNQTLSNLLNVKVELYCSGKLELVDKPSTITLPAQQSDQIICSIKATSAEAGRIYGNILYDIENVEERQLIPLSPITITPDNYMIPLKVDSIKYREKWEMFEWEKKITISSTLSIKEIITRYQEKGKMHLMNEFDDNASWATVNLCATSMFDEDVLLNISLEKTDNGTTEGYMRLRCASQPMAIAFSRLLMSINLNQ
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAAVRKMAQAAFSTTLRGAGARRTLLPARGARRFASTEGDASQSSSEASSMGGWVMAAMGIAGVGGPTTLEEAQRPMNLNEVQNYVTRATKRARQLYQDFTDPEPELLLPEPLPPQYRPTDYTIVLDLEDTLLHSEWTFEHGWRTKKRPFLANFLESCVMELGLELVVFSESQVAEAMLLIDKMDPKQCIQYRLYKPHMRYVDGEPVKDLDWLNRDLSKVIVIDDKPEQVRKHKDNVLRVRPFKGTPEQANDRELLDVLTFLANIVQSRVPDVRDVLRSYEGEESVAEAFQERQRLLLQQQLQHQQAVNEQNANQPRRKRFFGLLG
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSAIFNFQSLLTIILLLICTCVYIRSLAPSLVDRNETELLGIFWKCVRIESYLSLKSTRSLE
The following text describes a protein:
Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
Sequence:
MRIYEKGDFQGQMMEFFDDCPNTYDRFSFRDIHSCNVSDGHWMFYEEPNYRGRQYYLRHGEYRRFSDWGASTARIGSFRRVHHMV
The following text describes a protein:
Function:
Binds GTP and GDP.
Miscellaneous:
MISCELLANEOUS: Estimated to be present at 2000 copies per cell.
Sequence:
MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKNYNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVGNKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGKDVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPGIINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFICYMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVFSGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ferric enterobactin (Fe-Ent). Hydrolyzes Fe-Ent into three molecules of 2,3-dihydroxybenzoylserine (DHBS) still complexed with ferric iron. Iron reduction is necessary to obtain complete release of the metal from DHBS. It can hydrolyze salmochelin S4 (diglucosyl-C-Ent) but is not involved in iron acquisition by this siderophore.
Subcellular Localization:
Periplasm.
Sequence:
MRTSLLVAALGLALAAALPGGAPLAQPDPEATMDRSLLQRQDLPYRFSAVDLDSVDGQRHYRLWLGRPLQAPPAAGYPVVWMLDGNAAVGALDESTLRRLADGDAPLLVAIGYRTPLRIDRAGRTFDYTPASPGQADQRDPLNGLPSGGADAFLDLLRDGMRPAVAAQAPLDTARQTLWGHSYGGLLVLHALFTRPGEFARYAAASPSLWWRDGAILGERAGLEQRLRGKRAELLLWRGSAEPASPRGSLKAEPGQAMARLVDDLRRVAGLTLDFQPLDGLGHGETLGASLRLLLARPAVERQR
The following text describes a protein:
Function:
Confers resistance to puromycin, tosufloxacin and norfloxacin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLGSFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQLIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIITDSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALELGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFLYGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLMLISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRGTANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEIFQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMTKKAN
The following text describes a protein:
Function:
Required for the degradation of mRNA in mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MLIYKKKNFGRRSVYNLKKCLHKGFQINSCNIKAADNVLHSKASAFEKVNVVDKESIGNLQHHLDTVLPKKKFQFLRDPKTNDYKWDEYLSKILPVDKFNFGLLSKFRPPSEDEQLQKVANSIGAEFVGSTSSLTGLMSQLHFFISKWKFPNFSDLSKGFYISPNERNFTRLCRSASSVHISYQNGLYCIDKDKSLTKEPSVNIILMNVGKSLETFFTVDKDQFLLYKKPPSSNGVLKPLKDVFQYGRCSSLLVRSQLDCYDKKIPESGVFDLKTRAVFGVRMNQTQPELFKSYKLTHYYGNRISFEREYFDLIRSAFMKYSLQARLGYMQGVFVAYHNTSDIFGFQYIPLVAMDRAIHGSSEIGEAEFNLNLQLLEKILQYATSIFPKRSFRVMLSTTEDVPNPPLKVYLEVADDKENRGFDLLDGQKNLEAKTVSPSNFCALEVCALQFVNGVHKSVVKHLDEKETWSIKYHFRKPRDQDNLLRNYIRLRDDIKRRESKISNPPESLLHDYYACSEQYYKRN
The following text describes a protein:
Function:
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular Localization:
Nucleus.
Domain:
The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.
Sequence:
MEEEKRLELRLAPPCHQFTSNNNINGSKQKSSTKETSFLSNNRVEVAPVVGWPPVRSSRRNLTAQLKEEMKKKESDEEKELYVKINMEGVPIGRKVNLSAYNNYQQLSHAVDQLFSKKDSWDLNRQYTLVYEDTEGDKVLVGDVPWEMFVSTVKRLHVLKTSHAFSLSPRKHGKE
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLFYRFKSWYRLQAKKSPFIYVGLPFLSSVLLVWSCLIPISQVKFNRRDEQVKSLSRDAELDIIKRRRKVDVNEEYYRILLDQLNLQNEEYENKRVKRLKGEPTWEGNSSDKE
The following text describes a protein:
Function:
Plays an important role in meiotic recombination and associated DNA double-strand break repair.
Sequence:
MEALRSLKEAIIVYLDRSGGLRKFIKDCNDFKGAQQMEAVYRFSLDVNPSDVLQLDALLGDCILHDPIKAVSLFQSVCFLSIKTLSLIDHIETESQVNVVLKPTHLPPFPNYCLDLSEFPRGYGPMRPLALQGLVIAMTRVTKYTQGARFLCSEDACPCSRGFHHIRVHAPGATESATVRNDFTCFLCFSPLKEDVKSRVLGEKQLVELIHVRAVDVLGVHDPASLRYQSVTLFLRDELCNSMRIGHLYRVVGIPAHVHQWPNVTWSVEACSVQPWIPKCPSLVSNNFQNLHTASACSPWRFAAIVANSFGSPVIPPGLYNTLKLGLLLSLLQTEDNTDSPNHLDVLALTSDSLIIDRLMRYSLQLASRGIHHALTGELLASLSRDEHGASTANIHAGSALLASGGVCLLGDLTCYKKDKMDMLQSALESRTVSVFIPAKKYGDDTDQQLSFPIQCNFWALVDIASPSKRTARCDNALLGSGEMGSVPLQLTGAFGLVVQCRETSNNHPILSMTVHTLRQAMSPGEPLYPACMQFTTQDYKELLAHARQLKVDLSLDAERMIHGYYMGSRRFRSDSTQRSSVTSIKLLIALAQAHAKLSLRTEVLEEDAVIAVLLCESSVTLKHGASALIFPPDAAFPCALHDLDSLNQRDLELEEHRKQILNFVHTYAPHIEE
The following text describes a protein:
Function:
Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MELEGPWARVLHLHDACEWGRAVRARAVAPALEAAAWACLAMSVMLVLEVCYMSVSSFVAVNLLRRTPQRRYSWEPMPSGTARGDDEEAAVGDGGGEAYPMVLVQIPMYNEREVYKISIGAACALTWPPDRIIIQVLDDSTDPFIKELVEFECKDWASKKINIKYEIRESRKGYKAGALKKGMEHSYAQECDFVAIFDADFQPDPDFLLRTIPFLVHNPKIALVQTRWEFVNYNICLLTRIQKMSLDYHFKVEQESGSSVHAFFGFNGTTVRETVKSNSWSLQSYLTEAFTGTAGVWRVSAIGEAGGWKDRTTVEDMDLAVRASLKGWQFLYVGDIRVKSELPSTFKAYRHQQHRWTCGAANLFRKMAGDIVISKGATVWKKLHLLYSFFFVRRVIAPILTFLFYCVVIPLSVMVPEVSIPAWGMFYIPTAITIMTAIRNPWSIHLVPIWILFENVMSMHRMRAALTGLLETTYVDEWVVTEKVGDHVKDKLEVPLLTPVKPTECVERIYLPELLVAFYLLLCASYDVVLGAGHYYPYIFLQAFAFLVLGFGFAGTVTPCSCS
The following text describes a protein:
Function:
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Subcellular Localization:
Cleavage furrow. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring.
Sequence:
MESRCYGCAVKFTLFKKEYGCKNCGRAFCNGCLSFSALVPRAGNTQQKVCKQCHTVLTRGSSDTASKWSPPQNYKKRVAALEAKKKSSASQSQGLTHKDQAIAERLARLRQENKPKSIPSQAEIEARLAALKDEVQGPIPSTQEMEDRLAALQGRAPPPHTMRPVHQAPDTRTQAQQTQDLLTQLTAEVAIDENWQPRVSAAPPQNSLNKGGTRNQHTDSQGQASLEEEKNKLLAEASVELQEENTRQERILALARRLAVLKGQDPSRVTLQDYHLPDSDEDEDEETAIRRVLQQLTEEAALDEASGFNIPEEPAPASQAQPHKAKTEAEEEELPWCCICNEDATLRCAGCDGDLYCARCFREGHDNFDLKEHQTSPFHPRPPCREH
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). May also acts as a positive regulator of the Wnt signaling.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAESDVLSEIEVLQSIYLDELNVTQNDEGGWTVSLVLHPSTAEDCLSQFVRLTLTMDLDSQYPYSSPYISIHNPRGLSDDKLLSLQKSLQMEAEECVGTPVLYQLIERAKEILTDSNIPHGNCVICLYDFKEGEVFTKTSCYHYFHSHCLGRYITHSEMELKDRERELEEDKTRDRTEEEELAVVCPVCRESLTYDLDALLSSPAPVLCQQEDAVIGGEFKKKWEALQKILERQKEKGGVIDPEAESNRFLIHINEAPVNLSDTPGMTDSSGAESSQSLPSSSPDSTSTTQTSQNQHTAGQPQRKHTGDFKRGRRGRGAGRGGPARHMVPAPGEERLGKHIQSSDKINSANSGPTNTTSQVESTAQRQACELSENTAQLRQPLTNEENKPVSQDMLTSEPKDGQEVSQQKECISKEVTQTILQEGHPEREHVGRGDKRGSRGSARHHGHWQDRNYKGPGHWDNSGSAGHRGGAYRTREGGAGRGHRGGGAYRGGGRGMHQRVEKEFRKEGVL
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MESGSILDFIDNKTILVTGATGFLAKIFVEKILRVQPNVKKLYLLVRATDDKSAMQRFNTEAVAKDLFKTLKEKYGTNLQSFLSEKVTPIAGDITYENLGIKDSNLIQEMWKSVDVVVNVAATTNFDERYDIALALNTFGARNVYNFAAKCVKIKLLLHVSTAYVSGETPGLILESPYRLGDALNGVDGLDINVEKKIIEEKLKELSADETSTDKSITLAMKDLGIERANKFGWPNTYVFTKALGEMVLGHLKGDMPLVILRPTIILSTYKEPFPGWIEGIRTIDSLAVGYGKGRLACFLGDPESTIDVIPADMVANAMIATMAAHANQPGETIYHVGSSVSNPLKYKGIQKSGYNYFSKNPWINKDGTPVIVSEVKVLSSMDSFRRYFNLRYLLPLQGLQVVNSALCHAFSGTYSDLKRKINFVLRVVELYKPYLFSKSFYDDMNTEKLRQLVKENEVEANIFYFDPKTIDWEDYFLHTHLPGAVKHVFK
The following text describes a protein:
Function:
Negative regulator of pollen germination. Prevents pollination in moist environments by inhibiting jasmonic acid synthesis. Stabilizes pollen tube growth.
Subcellular Localization:
Nucleus. Cytoplasm. Note=The nuclear protein is functional.
Sequence:
MFTEADSIPRAKYANMMHSDPNLSSTMTQQTEEEYGIRNSSASAVGTGMYDRMSCEGSPMMMSPWNQATPFTQTQWSTVEENLPQNGLIGSLVREEGHIYSLAATKDLLYTGSDSKNIRVWKNLKEFSAFKCNSGLVKAIVISGEKIFTGHQDGKIRVWKVSPKNQSLHKRSGTLPTLKDIFKASLKPRNYVEVKKHRTALWIKHADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLESIPAHDDAVNSVVSTTEAIVFSGSADGTVKAWKRDQQGKYTKHTLMQTLTKQESAVTALAVSKNGAAVYFGSSDGLVNFWEREKQLNYGGILKGHKLAVLCLEVAGSLVFSGSADKTICVWKRDGNIHTCLSVLTGHTGPVKCLAVEADREASERRDKKWIVYSGSLDKSVKVWGVSESFIDMNQMSMMQQQQQQHVISHSEPFMSDGSFSSSAGGASSHRRH
The following text describes a protein:
Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome.
Sequence:
MWESICLTLAATAGNNIGKVLQKKGTIILPPLSLKLKVIRAYAGNKPWALGFLMDIFGALLMLRALSLAPVSVVQPVSGCGLAILSVFSHFYLKEVMNVFDWIGITMAGIGTIGVGAGGEEQVASLISVFQLLWLALVVAFLFVLLNAWLHIYKRQRREQELMEYEVVEEIIYGLESGVLFGMASVVSKMGFVFVEQGFSAMFIPMCISISICCSGTGFFYQTRGLKHGRAIVVSTCAAVASIVTGVVAGMFALGEKLPTSPSGRLLLLLGWLLIMLGVVLLVTSSRLIRHLPRSFRRSRQTSLERGFSTRRTASHVQKDTNPSAVIQAATLHHLLTTPSKEKD
The following text describes a protein:
Function:
Transfers electrons from cytochrome c551 to cytochrome oxidase.
Subcellular Localization:
Periplasm.
Sequence:
MKLLSTIAVLALVSLAPSAWAKTCAVTITGTDQMKFDQSAITIAPDCTEVAVTLKHSGKLAATVMGHNWVLTKSDDFQAVANAGVRSTIADSYLPKADPRVIAHTKVIGAGETATVTFPTSKLSKGGAYTFFCSFPGHWAMMKGTLRFG
The following text describes a protein:
Function:
Possesses activity on acetaldehyde and glycolaldehyde in vitro.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MASRRVSSVLSRSFTSASLFSAGRSSSVARGIGKYSTDASFEAPIIPSVKVNYTRLLINGQFVDAASGKTFPTLDPRTGNVIAHVAEGDSEDINRAVSAARKAFDEGPWPKMTAYERSRVLFRFADLVEKHNDEIATLETWDNGKPFEQAAKTEVPMIVRFFRYYAGFADKIHGLTVPADGEYHVQTLHEPIGVAGQIIPWNFPLLMFAWKVAPALACGNTVVLKTAEQTPLSALYVATLLQEAGLPPGVLNVVSGFGPTAGAALCSHMEVDKVAFTGSTDTGKKVLELAAKSNLKTVTLELGGKSPFIVCEDADVDKAVELAHFALFFNMGQCCCSGSRTFVHERVYDEFIEKARARAEKRIVGDPFKGGVEQGPQIDSDQFEKILRYIDYGIKSGATLETGGGRLGTKGFYIKPTVFSNVKDDMPIAQDEIFGPVQSILKYKDLDEVIRRANTTRYGLAAGVFTQNIDTANTLTRALRVGSVWINCFDVFDAAIPFGGYKMSGHGREKGIYGLSNYLQVKAIVTPLKNPAWL
The following text describes a protein:
Function:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGTRKRLISPTEPSPDPKQTTTQDKPLQQQTTDPPIAPPKWGFLFKLSLFSIPYFYLIFFHFTIDSHLRRSIIINAGLSLAGFFVTVRMIPVASRYVLKRSLFGYDINKKGTPQGNIKVPESLGIVVGIVFLVVAILFQYFNFTADSNWLVEYNAALACVCFMTLLGFVDDVLDVPWRVKLLLPSIAALPLLMAYAGHTTIVIPKPLVPHIGIEILDLGWIYKLYMGLLAVFCTNSINIHAGLNGLEVGQTVVITYAILIHNIMQIGASTDPEYKLAHAFSIYLVQPLLATSLALLSYNWYPSSVFVGDTYTYFAGMTMAVVGILGHFRTGCPYPISLLLGSIFFLFVFYCAIYDYLMDLDQIYISCIISLNQISSPSSLNLIQIFSSFVDSPPNEILSAVDSPSYEILSAVDRYEILLASSFYVDLDSLIVIDYLAPPRIFCPIIRSELSHLYANGSL
The following text describes a protein:
Function:
Zinc transporter that mediates zinc uptake from the rhizosphere and may be responsible for the translocation of zinc within the plant.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing ZIP4 show decreased zinc concentration in shoots and seeds, and increased concentration in roots.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDAMRQSTPRAMLLLCAVLMLAVAPPGAATAAAVAGCECGNAAAAAVAGEDARGALRLKLVAIASILAAGAAGVLVPVLGRSFAALRPDGDVFFAVKAFAAGVILATGMVHILPAAFDALASPCGGGRGGGGGFPFAGLVAMAAAMATMMIDSVAAGYYRRSHFKKPRPVDDPADAARAAGVEEGGAEHAGHVHVHTHATHGHAHGHVHSHGHGHGHSHGSAPAAATSPEDASVAETIRHRVVSQVLELGILVHSVIIGVSLGASLRPSSIRPLVGALSFHQFFEGIGLGGCIVQANFKAKATVIMATFFSLTAPVGIALGIAISSSYSKHSSTALVVEGVFNSAAAGILIYMSLVDLLAADFNNPKLQTNTKLQLAVYLALFLGAGMMSLLAIWA
The following text describes a protein:
Function:
Protein kinase that functions as a regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3. Diminishes transcriptional induction of genes in response to pheromone signaling.
Miscellaneous:
MISCELLANEOUS: Present with 1510 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEYSSIYSQPKTPRLKQEGFPDSIGDQHEKALIDENGEEDKKMASTEGTTGDSRSTPLTVSIPTFENVQALPTPMTYTPLSPGNLSMSPIDQSSLNIPKRRSHARLLDDMLSVTQPNQRVVSELIAPANLSPQRVVSLPTVTEEALVNDSVDSDNYTKEPYFPESSSSTEKCDDDIFQGFLLDHWDRPLLWKKVRPIGSGNFSTVLLYELMDQSNPKLKQVAVKRLKYPEELSNVEQINTSLRYKETLSRLENSLTRELQVLKSLNHPCIVKLLGINNPIFVTSKKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVMARNGRLEAWLIQRIFTEVVLAVKYLHENSIIHRDLKLENILLKYSFDDINSFRDSPIYCKQNFIELADFGLCKKIENNEMCTARCGSEDYVSPEILMGVPYDGHLSDTWALGVILYSLFEDRLPFDPPPNASARQRSRATSHRIARFDWRWYRLSDYKTNVGKQIVENTLTRKNQRWSINEIYESPFVKTIADTLSFS
The following text describes a protein:
Function:
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Subcellular Localization:
Cytoplasm. Nucleus. Secreted.
Sequence:
MAKVPDLFEDLKNCYSENEDYSSEIDHLSLTQKSFYDASYDPLPEDCMDTFMSLSTSETSKTSKLNFKESVVLVAANGKTLKKRRLSLNQFITNDDLEAIANDPEEGIIKPRSVHYNFQSNTKYNFMRIVNHQCTLNDALNQSVIRDTSGQYLATAALNNLDDAVKFDMGAYTSEEDSQLPVTLRISKTRLFVSAQNEDEPVLLKEMPDTPKTIKDETNLLFFWERHGSKNYFKSVAHPKLFIATKQGKLVHMARGQPSITDFQILDNQF
The following text describes a protein:
Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MSDPVADFMAREQEMMAALEGDVPPPPVPVVADPIPDLADEFGALAAAPADPVFINGGDSGVDLSAMDIPAAPVMAHNDDLADFVAVNGNGFGGSHSSSASNGPSPVPSMPRIEAENIRKWREQQAARLEKKDEAEEKKKQELRAQGKKELSDWYAQREAALKVASEANRKAEAEHLAAFAKAQGDGAQWDEVAKLCGDGKTAKGGKDVSRLKSMLLHLKEQHAK
The following text describes a protein:
Function:
May play a role in mRNA transport.
Sequence:
MPNQGEDCYFFFYSTCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRRVCRFRHMEIDKKRSEIPCYWENQPTGCQKLNCVFHHNRGRYVDGLFLPPSKSVLPTVPESPEEEVKASQLSVQQNKLSVQSNTSPQLRSVMKVESSENVPSPKHPPVVINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLHFGIKTLEEIKSKKMKEKSEEQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLGLTETLGKRKFSTGGDSDPPLKRSLAQRLGKKVEAPETNTDETPKKAQVSKSLKERLGMSADPNNEDATDKVNKVGEIHVKTLEEMLLERASQKHGESQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEEEHRQQEAERQKSKKDTTCIKLKTDSEIKKTVVLPPIVASKGQSEEPAGKTKSMQEVHMKTVEEIKLEKALRVQQSSESSTSSPSQHEATPGARLLLRITKRTWRKEEKKLQEGNEVDFLSRVRMEATEASVETTGVDITKIQVKRCEIMRETRMQKQQEREKSVLTPLQGDVASCNTQVAEKPVLTAVPGITWHLTKQLPTKSSQKVEVETSGIADSLLNVKWSAQTLEKRGEAKPTVNVKQSVVKVVSSPKLAPKRKAVEMHPAVTAAVKPLSSSSVLQEPPAKKAAVDAVVLLDSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLTWEISGGKLEAEIDLDPGKDEDDLPLEL
The following text describes a protein:
Function:
Catalyzes the addition of a phosphorylinositol group onto dihydroceramide to form phosphoinositol dihydroceramide (PI-DHC), an essential step in sphingolipid biosynthesis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPSKKETLTVIVIMALFLLLTAACIGLRSEHLLMAALYLVLFFAGLPTRKLAVALLPFAIFGISYDWMRICPNYEVNPIDVAGLYNLEKSLFGVMDNGVLVTPCEYFAVHHWAVADVFAGIFYLCWVPVPILFGLCLYFKKERKTYLRFALVFLFVNLIGFAGYYIHPAAPPWYAINYGFEPILNTPGNVAGLGRFDEIFGVTIFDSIYGRNANVFAAVPSLHAAYMVVALVYAIIGKCRWYVIALFSVIMAGIWGTAIYSCHHYIIDVLLGISCALLGWLFFEYGLMKIRGFRNFFDRYYQYIK
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MSMTASNAEDSEMEDLSQCSQEDEESRRRQLRRAYRDLINRTVADPDDETAVPPTETLDEAKQLFSKVTRTQEAVLDSKLMVLMASKGRKCASLLPINLHTFDAEEFAGRALSIMGTSAPVGQKLDLAAWAQLGSFAEEPLKRSAPFWYLYGAAGEVPPRVRQARRTVVEVPDRPETVAKKVSSGDRTNKETTTEHVGHIHGLLKALHSRLGGPLSYHEFVIHPTSFSKTCENIFHLSFLINEGHARIIEEDGLLLVEPVDRTSSSAASQAANRNGVFVKTLTMTQWREAVRGLGTREPTIAD
The following text describes a protein:
Function:
Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPAKKIRSSPREAKNKRRSGKNSQEDSEDSEEKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLVEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPLEKKASSSPPPEKSGDEGSEDDAQSGED