lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors. Competes with ethanolamine ammonia-lysase (EAL, the first enzyme in the EA degradation pathway) for adenosylcobalamin.
Sequence:
MKKTRTANLHHLYHEPLPENLKLTPKVEVDNVHQRQTTDVYEHALTITAWQQIYDQLHPGKFHGEFTEILLDDIQVFREYTGLALRQSCLVWPNSFWFGIPATRGEQGFIGSQCLGSAEIATRPGGTEFELSTPDDYTILGVVLSEDVITRQANFLHNPDRVLHMLRNQSALEVKEQHKAALWGFVQQALATFCENPENLHQPAVRKVLGDNLLMAMGAMLEEAQPMVTAESISHQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQSMTVKDAAMQWGFWHLGQFATDYQQLFSEKPSLTLHQRMREWG
The following text describes a protein:
Function:
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MPGKRIMVVGAGVSGLGAIKICLEEGLEPICFEESNDIGGLWRYEEKTERGRPSVYKSVISNTSKEMMAYSDYPFPDHFPNYLHNSKIMEYLHMYVKHFHLLKHIRFLSKVCSVRKHSDFSFTGQWDVVVGLFTNPFMPLQKFPGIMRFKGQYIHSWEYKSPEKFQGKKIIVIGIGNSAIDLAIELSHVAAQVFLSTRSGAWIWNWVWDSGMPMDTVLFTRFNSLVKKIFPEFLIHRWAENKLNVRFNHDIYGLLPQHRYVLGFFGDDLPNYIITGRVRMKPNVTKFTETSAIFEDSTEEDVDVIIFATGYTCSFPFLENNSTVLDIQRSMYKFVFPPELEKPTLAFIGILQPVGATIPTSELQSQWAARVFKGLNKLPSVSGMLADIRKKRTKLEKQVQYVDYMDEIASEIAVKPNLFSLFLWDPKLALELFLGPCTSYQYRLQGPGKWAGAREAILTQRERIIKPLRTRTLICAQAPCCVPLWLKSICVALLLFVLTFIIIKG
The following text describes a protein:
Function:
Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MHPFKRLSWTHLFFKPFWSSPRISCASIVTCTHQSFSSPCTRACKHTSRRQEVPSTGNSVFIVHTLSLKQTFRMSFARRPITPIEILRNCRGKEVSIELADGETVNGTVMRTDRAMNVVIKQCTRTGADGESFWKSRECFIRGASVKNVRMTDSALVAVPVLSKRKAAGSKGADTRKEKSVAGGKRPRR
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MAARKQGKTNFAVTCNLLSQYIKEKGRIADLGLGMAPRPQDATKGKSEAFRPPTTMSLLPGADVSSGEGEQEEGVFMEPFPERAGFGPSLAAVPENAREQERAPLTIFYGGKVLVFDNFPLEKAKDLFQLASRGNSTAQNFGNLPRTAQPNLSYLPIARKVSLQRFLEKRKDRIHSRAPYQVSSSPGMVTPVKQENRSWLALGPQEAKL
The following text describes a protein:
Function:
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
Subcellular Localization:
Cell projection, ruffle membrane; Peripheral membrane protein. Cytoplasm, cytosol. Synapse, synaptosome.
Sequence:
MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNSSSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPLELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMVLSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVRGRAHTPGPVFTQACGLGLGFFVLVKKPRPSLGPRVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSVAKPKLDQALLVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYFLRSSSVLGGRMGFVHNFHESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAHSPSPTHTHHRAFSFSLPRPAGEAPGLQRSERRRFRRWRMASSTSTCN
The following text describes a protein:
Function:
Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.
Subcellular Localization:
Virion tegument. Host cytoplasm. Host nucleus. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.
Sequence:
MASRRRKLRNFLNKECIWTVNPMSGDHIKVFNACTSISPVYDPELVTSYALSVPAYNVSVAILLHKVMGPCVAVGINGEMIMYVVSQCVSVRPVPGRDGMALIYFGQFLEEASGLRFPYIAPPPSREHVPDLTRQELVHTSQVVRRGDLTNCTMGLEFRNVNPFVWLGGGSVWLLFLGVDYMAFCPGVDGMPSLARVAALLTRCDHPDCVHCHGLRGHVNVFRGYCSAQSPGLSNICPCIKSCGTGNGVTRVTGNRNFLGLLFDPIVQSRVTALKITSHPTPTHVENVLTGVLDDGTLVPSSKAPWVLLRMSDYFSRLLIYECKKLKALGLRSY
The following text describes a protein:
Function:
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MIQTWTFYTLTPLLTTHTFMIGKELEPIFAIIACSRAGLTSFYMFRIYLLVFEGYLNVHFQNFNGKKNSSFYSISLWGKEEKIKNKIHLLALLTTNNNERFANDNENDITEATLRNAVSATEEGFLDFAKMNYMHQPNLGYVGSCCLAGIIWKETLHVANLGDSRVVIGTMVNKKIRAEQLTRDHNCNDEAIREELRAMHPDDPNVVINDNGSWRVKGFITVSRAIGDAYLKRSEFTLRESFPKLEIVPEPFTRGVLSAEPEMHTRVLTDNDKFIIFASDGLWDFLSNKKAAEIVQKNPRNGIAKRLLSTALAVAAKRRKVTYRKIQAAATGRNNVSRRSFHDDISVIVVFLDKTSFPRQPVLNLSYTGSSDMPVQSDFAQFGLTTSRLQSLRHRSLKDIIQFESGSSHASSSQGPRTPLALNPQTLEGESSRAQSNR
The following text describes a protein:
Function:
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MCPAVRPWALLLLGGAWAAACSAAAPLRTFPVSDWSLTHLVVHNKTGEVYVGAVNRIYKLSSNLTLLRTHVTGPVDDNEKCYPPPSVQSCPHGLAPTNNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVLIEVPGGHDKLFVGTPIDGKSEYFPTLSSRKLMRNEENAEMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFSSEQFVYYLTLQLDTQLTSPDSTGEQFFTSKIVRLCVDDPKFYSYVEFPIGCVQAGVEYRLVQDAYLSKPGRALARQLGLAEAEDVLFTVFAQGQKNRVKPPKESVLCLFTLQKIKDKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKEDGMTSVAAYDYQGHTVVFAGTRSGRIKKVIDSLVSGPVGRDGIGRASDPQDSPTPAQEAPEKRPEPTPIGRSVDERSQSVLVARAELWSRGKGATLRALTLGHGSLRHVHLSDLSEEHSSHQPSRFFLRSCLSCVNGSFPCHWCKYRHICTHNAADCSFQEGRVNVSEDCPQILPSTQIYVPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGNPARVTALRFNSTSIQCQNTSVSACPCAQLSRAQWDGARRAWDREDVRACTNASAFPRIVCEIGDASPGRAHDALVEVCVRDCSLHYRAVSPKRFTFVTPTFYRVSPARGPLSGGTWIGIEGSHLNAGSDVTLLASPDLCPLFFPRRNSREIRCRTPPGQSPGGANIVININRAELSNADVKYNYTEDPTIQRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGSAERENTCIVYNDTTMMCQAPSIDNPSRSPPEMGDRPDELGFVMDNVRSLLIINSSNFLYYPDPVFEPLSPSGILELKPSSPLILKGRNLLPPASGNSRLNYTVLIGSTPCVLTVSETQLLCESPNLTGQHKVTVCAGGFEFSPGTLQVYSDSLLTLPAIIGIGGGGGLLLLVIIVVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVLKEMEVGAPPGDGRMEGIFWSSILWQMAPGSRAADAHVIRMIFERECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKMLTLNCVNPENENAPEIPVKVLNCDTITQVKEKLLDAVYKGVPYSQRPKAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQNSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDYDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYSDIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYITKYKDEILAALEKDEQTRKQRLRSKLEQVIDTMALSS
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.
Sequence:
MIKVFFSNENYFIWTAEDACKVRKVFRIVGNMVGCLPSSPLQNAQMGLPLLLMQCEARLLVEKGFACIVDEFSIKKSKNHIQLIAQKRKQVFDEQVALCKKEKHHQMEINMQKIIDGKRKKIFNQNDEISAADLSKQIEEELLVERKRIDCLKLSQSSALVQTHTSRYPSEKIKDNKAQYAWKSSIDFHLDKKYYVFKYFWEQNYFITSGLKFGGDFLVYPGDPSRYHSFYIVLCVQHDEAINLLQLIRMGRQATTVKKTFVLASVDFNNTYNVNCVSIQWPKA
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVGIDEAGRGALIGPMIVAGVVISDTKLKFLKGIGVKDSKQLTRERREKLFDIVANTVEAFTVVKVFPYEIDNYNLNDLTYDAVSKIILSLSSFNPEIVTVDKVGDEKPVIELINKLGYKSNVVHKADVLFVEASAASIIAKVIRDNYIDELKQVYGDFGSGYPADPRTIKWLKSFYEKNPNPPPIIRRSWKILRSTAPLYYISKEGRRLW
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the second step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MHNMESLCIGSRISVTGDSATVKYIGTVPPTKGEWLGVEWDDPTRGRHDGTKDGVAYFKCRNRHKTSGSFIRATKANFGVSICDAITDRYTLPTESGDSHMNDMYLGNIKIMKKIETVGMDQVQKQFGKLNQLKQIILRDQIISSAGTVGQLATLTPSLVELNLSKNLISSWDTVCDIVKQLPCLKVLNLSENIMQVTDKALSQPEVFANIDTMVLNKCSLSWEELLTCTTMWPQVTELHIEANNMTHLSPPGDKLNHVKLLHLSGNPLNSWHEVQQLSQLPMLSCLLIKECELSDLFIKPEEKGCLINKIQFISPLLLVMQQVHDLNPLNNLPEFIELHFRKNPALNQDRYDAIHDIIVAKIKRLQRLDRLSVTQQSRFTAEMDYLRKYGVEWRESGGHQDPERNQPSQEFIENHPRYMELIAEHGAPDDKQFMKMSSALKGNLLELIIEAPVKPDFKPVTKKLPKSMSIGSLKLLIQKLTKIEIRNQRLVYISKENPDHVVELDRDHETLHDVSIDPGDTIQVLSGYHWAKKTSRRKPRH
The following text describes a protein:
Function:
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
Subcellular Localization:
Nucleus.
Sequence:
ARVPDDDMNSLEDSDSMESCFAGEEEFYSSTLTPPTPSEDIWKKFELYPTPPLSPSHNPDDKESDRHPRHHQQDGDGSPSRSYQHLMDDDDLPLVNPQVPLLDLSSAPPIAALIQDCMWSSIIAEERRKLFMKSEKKHAEERATKKASTPSSGVMLPPLVPASEYGTSDCVDPSAVCPYPLSETRLDLFSSGTNTPSDSEEEIDVVTVEKKHHSVHKINTTRPYHKQSTKVRHQLHHRPISVALVGSLRGRPSTATILSIPIKKLKTEGNLEEVKQILQKSNLIRSSSGSSRGSSRGCSRNSSSRRVNQVSHPSSDSEDTEKRACHNVLERQRREDLRTSFLLLRDEVPELGTCDRAAKVVILKKATDYVSSLRDREETLRMDMATEKNRNLQLRRRLEALLAPLTL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains. HEL2 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs. Acts as a ribosome collision sensor: specifically recognizes and binds collided ribosome and ubiquitinates the 40S ribosomal proteins RPS20/uS10 and RPS3/uS3. Catalyzes 'Lys-63'-linked polyubiquitination of RPS20/uS10, promoting recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides. HEL2 also acts as an activator of the No-Go decay (NGD) pathway by mediating polyubiquitination of monoubiquitinated RPS3/uS3 and RPS7/es7: RPS3/uS3 and RPS7/es7 are first monoubiquitinated by MAG2 and MOT2/NOT4, respectively, and HEL2 mediates formation of 'Lys-63'-linked polyubiquitin chains on monoubiquitin, leading to activation of the NGD pathway in a CUE2-mediated endonucleolytic cleavage. Polyubiquitination of RPS3/uS3 also triggers degradation of non-functional 18S rRNA. The RQC pathway and the integrated stress response (ISR) antagonize each other: HEL2 prevents the activation of GCN2, while GCN2 suppresses RQC activation. The RQC pathway functions as a preventive quality control in the secretory pathway: HEL2 binds preferentially to the pre-engaged secretory ribosome-nascent chain complexes and prevents mistargeting of secretory proteins into mitochondria. Independently of its role in RQC, also involved in the polyubiquitination and proteasomal-degradation of excess histone proteins.
Miscellaneous:
MISCELLANEOUS: Present with 1960 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSESVKENVTPTRNFRRTQGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTSSADDTDEENELCVICARKLTYVSLTPCHHKTCHICGFRQRALYNKKSCLICRTENEEVMFTDRIDGDISDKYNFCEKNEKYGINFTSEEVATETLNLLKFFCPLSKDEQVCDFGSFKKYNEHLKSEHNRMICLICATHKHAFPCELEIFTQNQLRNHQTKGNSEGFKGHPMCAFCSGKRFYSDDELYIHMRNQHEKCHICDKMNPASPQYFKDYNQLFDHFKHSHYVCTVQTCLDNKFVVFKDELELQAHILQEHGNILKGKPKFFQSELSTFISAPSRVIRERDDYDLPSISSLPGSSSGSRTDVRSASSPEESRLRLAERAKYYLENSKEDFNKFSSYNEDYSKGRLSAEKLLESYKLLFTKPNADVYLLIHNLAETFPKNSSKYNNLNAIYEQREQTLARQTSLPSLSSDSSLSMSIGRGHWGGTNDGGSAGAALGVRNIKNLPTLKSPSASYDPFATTVKKNTLRPVQNIKRTTPQSVSYRTSTNTVAFSPTYLESKKGSSSTSLNNSKDKLKSLNLPQLPPPKPKVQIPGLNRPQIADPKQWGKKSSTQDTNVHDNLRELNTTSGGNKKKGKQKQLLFHIGV
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.
Sequence:
MNAIRKPNPRLYIRVNTLKTSVEKILERLPHFKPDEDFKEAIYVEIKGPNEINIHENKVIVDKKTAESAMLGANVYKPGLKSVVINNAKDKRVTVYSDNGIPVAEGKYYGMNTNLVVEVTNSLYTSPKLADLPELKNGLIYVQGKASMYVAHLLDPHPNEKIVDMTAYAGGKLTHIYQLEPRVKLIGFDHTEKKVEKLRDLANKMGMRIEIYKADSRYLYEDYKIGDVDKVVIDPPCSALGIRPKLYDHKTKQDILNFHKYQKQFLNSAYKILKKNGVVIYSTCTVTTWENEKVINDPRFSVEYEIRFHPHIHEITGFFIAKLIKKG
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEPNEGVQLFSAFPPPPPYYKLFTRENIEKVISNMEKEAKHEDDANTLQPKTEEEIESLAKLFKKPSCLTSGTYQMFGDTWRLDEAIPSLKEFGIPELYKDIKDGEDEIEVVEYDPKSNAIVGTSFTRVHDYDKNSPIENEKILEDDQHTAMKEKDNESDKTMKDVEEKTEPSLKKEEEDIQMKEPLDSQDTGAVSASSVNEGFRADQKSKDGETSDLIKIPRRAYELRFLSRSLMLNFLELLGIMAKAPEQFPSKVENIRVLLLNLHHLINDYRPHQSRESLIMLLEKQLKHEESQVELLRTHNRQMTETLEKYKSLDFNMEKEGDVIQQLKSSIKKPLSGAEDEQKSRSMFSKNDEKLKKSLELMEDVIKRDLS
The following text describes a protein:
Function:
Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His-860 and Asp-733.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNLTLTRRLWMGFALMALLTLTSTLVGWYNLRFISQVEKDNTQALIPTMNMARQLSEASAWELFAAQNLTSADNEKMWQAQGRMLTAQSLKINALLQALREQGFDTTAIEQQEQEISRSLRQQGELVGQRLQLRQQQQQLSQQIVAAADEIARLAQGQANNATTSAGATQAGIYDLIEQDQRQAAESALDRLIDIDLEYVNQMNELRLSALRVQQMVMNLGLEQIQKNAPTLEKQLNNAVKILQRRQIRIEDPGVRAQVATTLTTVSQYSDLLALYQQDSEISNHLQTLAQNNIAQFAQFSSEVSQLVDTIELRNQHGLAHLEKASARGQYSLLLLGMVSLCALILILWRVVYRSVTRPLAEQTQALQRLLDGDIDSPFPETAGVRELDTIGRLMDAFRSNVHALNRHREQLAAQVKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATAIADDMPCALMGDPRRIRQVITNLLSNALRFTDEGYIILRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATAPVPKTVNQAVRLDGLRLLLIEDNPLTQRITIEMLKTSGAQIVAVGNAAQALETLQNSEPFAAALVDFDLPDIDGITLARQLAQQYPSLVLIGFSAHVIDETLRQRTSSLFRGIIPKPVPREVLGQLLAHYLQLQVNNDQSLDVSQLNEDAQLMGTEKIHEWLVLFTQHALPLLDEIDIARASQDSEKIKRAAHQLKSSCSSLGMHIASQLCAQLEQQPLSAPLPHEEITRSVAALEAWLHKKDLNAI
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC32.
Subcellular Localization:
Secreted. Note=Following 6 weeks of nutrient starvation.
Sequence:
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
The following text describes a protein:
Function:
Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (By similarity). Required for proper circadian rhythm.
Subcellular Localization:
Nucleus.
Sequence:
MTESIDLNRSESESDNNTDDVTPIFAIDDSSKGRVSGPTRRSTKGGWTAEEDQILTNVVKKYQGRNWKRIAECLPGSEENRRNDVQCQHRWLKVLDPSLQKGAWKKEEDELLSELVKDYMENDRPPWSKISKELPGRIGKQCRERWHNHLNPTIIKSPWTREEELILVQAQRGNGNKWAEIAKLLPGRTENNIKNHWNCSVKKRLEQFPSNLFSGVVYGSKPSSGFEYNFFNQRNTMVESCITSQIKEAAKSPQRDFLDLTLGLNWRSISSSTSSLRGEESVSSSVDSVCARLNACLETPQNSNNDTVCVKEVREMKERLRMAARTFDTPSIISKTSSPASGLKRLRQKYDTPFPTDARSHMSSEEDHSVSASPSSKYRFVKRNTCSGSKPLERRLDFDFLLWDEHGRRNGIVNFSVRILPQKSDLKSGLVRPFWLR
The following text describes a protein:
Function:
Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity).
Sequence:
MRVAALISGGKDSCYNMMRCIAEGHQIVALANLRPDDNQVESDELDSYMYQTVGHHAIDLYAEAMALPLYRRTIRGRSLETGRVYTRCEGDEVEDLYELLKLVKEKEEIEGVSVGAILSDYQRVRVENVCKRLNLQPLAYLWQRNQEDLLREMIASNIEAIIIKVAALGLDPDKHLGKTLGEMEPYLLELSKKYGVHVCGEGGEYETFTLDCPLFKKKIVVDTSEAVIHSADAFAPVAYLRLSGLHLEEKVSSVPGDDETTSYIHNS
The following text describes a protein:
Function:
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MHPPRPTTDLPEDFYIPMALDAPNITALSPFLVPQTHLGSPGLFRAMAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLGGMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWSRYIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRAVARQQEQSATTQKADREVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQFRSCMLKLLFCGRSPFGDDEDVSGSSQATQVSSVSSSHVAPA
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATSSGKTKNVGKSNRLNDGKRKEELLVGARKRVECEKKAMKIVERLLEESISESFFEDCGKYITSNQFEDVAVERAIEKLCGYPLCTNKLTSIPRQQYHISLKSKKVFDITERKNFCSQRCFQAHAYYQTQLSDEPVWAREHKNIPPIKLFENDASAATNAPLKHPHEIPLKHKITMPDVDTVSERTAEGAGEGEKGLHLGVSGLSLDRSNEGVDGGRKDKDKRREEMLRRVAESVERPARDGQREEVQSSGSHVEGSSYAVEPSSSVTVGQEDMKHTVTPEELHLSNQVKPVQTCSASNIVNERLVMPNNGNTDGDWKDEPNQINPVQIGSEESKDTDVALGESGRKDNVGDLTAQPDDHGVTVKKEEADEIQQEKTVSSTDTRTSKEKKKTKKKKKKVPVAENTMLVILQHIQQCLMEWRTVETLRYIYGRSSSQSGNQGCIDEPVPDTVPETDPNLERKKMALKEFEKRAGDRLDREEIKEGAFPAPSKPLPDFESLRREEEEKYALKVKEYFMGREMKTPSKPATEEKEEEPNKLVENTVDRTGGLPPVDSRAQVTIRRRILLDKLTQILPGIAVSLQLSVHEVSPMMTDLVRTFHPGSHNIVFKPLAWNLMTLILIHM
The following text describes a protein:
Function:
Primarily acts as an independent SigF regulator that is sensitive to the osmosensory signal, mediating the cross talk of PknD with the SigF regulon. Possesses both phosphatase and kinase activities. The kinase domain functions as a classic anti-sigma factor-like kinase to phosphorylate the anti-anti-sigma factor domain at the canonical regulatory site, and the phosphatase domain antagonizes this activity.
Sequence:
MTEHPTSFDRPSTGADPTDPRGALLPAPVPPRASGSALPAQGRTGETPPTAGEDSPGVFEHSQPGAEQAAEPDTHRPRPGAEGVPVQPDGGQPDGGQAGGGQPGGVPAGAAPRVAPSDGSALDGMPGGGQAAEVRPGSEVPAGATDRRDAPAEPDRRTGQPTAPGQPTPMRRDGDRLRFVGAATRRIARGMDLDEIVMGLCRATVPTFADAILVYLREPLPVGDERPTGPLVLRLRRTDRIPAERDTEGGFAPAAQPEPSELETVGAELCEVRPGSALAEVLRGVRPVFTDTPAARAALPELLGEERDFALPDGRRAILAPLRGRRRVIGAALFLRGPERIPFEADDLLVAAQLATHSALGIDKAVLYGREAYIADELQRTMLPENLPRCTGVRLASRYLPAAETARVGGDWYDAIPLPGSRVALVVGDVMGHSMTSAAIMGQLRTTAQTLAGLDLPPQEVLHHLDEQAQRLGTDRMATCLYAVYDPVSHRITVANAGHPPPVLLHLGGEAEVLRVPAGAPIGVGGVDFEAVELDAPAGATLLLYTDGLVESRLRDVWTGIEQLRERLAATAQLTGPDHPPPLEALCDEVLDMLGPGDRDDDIALLAARFDGIAPSDVSYWFLDPEDAAPGKARRLARRALARWGMEDLTDAVELLVSEVVTNAVRYASKPVTLRLLRTDVLRCEVGDDVPQLPRLRQARATDEGGRGLYLVNRLARRWGATRLSTGKVVWFELNRG
The following text describes a protein:
Function:
Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway. Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (Probable). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity).
Subcellular Localization:
Peroxisome.
Sequence:
MAEYLRLPHSLAMIRLCNPPVNAVSPTVIREVRNGLQKAGSDHTVKAIVICGANGNFCAGADIHGFSAFTPGLALGSLVDEIQRYQKPVLAAIQGVALGGGLELALGCHYRIANAKARVGLPEVTLGILPGARGTQLLPRVVGVPVALDLITSGKYLSADEALRLGILDAVVKSDPVEEAIKFAQKIIDKPIEPRRIFNKPVPSLPNMDSVFAEAIAKVRKQYPGVLAPETCVRSIQASVKHPYEVGIKEEEKLFMYLRASGQAKALQYAFFAEKSANKWSTPSGASWKTASAQPVSSVGVLGLGTMGRGIAISFARVGISVVAVESDPKQLDAAKKIITFTLEKEASRAHQNGQASAKPKLRFSSSTKELSTVDLVVEAVFEDMNLKKKVFAELSALCKPGAFLCTNTSALNVDDIASSTDRPQLVIGTHFFSPAHVMRLLEVIPSRYSSPTTIATVMSLSKKIGKIGVVVGNCYGFVGNRMLAPYYNQGFFLLEEGSKPEDVDGVLEEFGFKMGPFRVSDLAGLDVGWKIRKGQGLTGPSLPPGTPVRKRGNSRYSPLGDMLCEAGRFGQKTGKGWYQYDKPLGRIHKPDPWLSTFLSQYREVHHIEQRTISKEEILERCLYSLINEAFRILEEGMAARPEHIDVIYLHGYGWPRHKGGPMFYAASVGLPTVLEKLQKYYRQNPDIPQLEPSDYLRRLVAQGSPPLKEWQSLAGPHGSKL
The following text describes a protein:
Function:
Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome throughout cell cycle progression. Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP.
Sequence:
MATVAELKAVLKDTLEKKGVLGHLKARIRAEVFNALDDDREPRPSLSHENLLINELIREYLEFNKYKYTASVLIAESGQPVVPLDRQFLIHELNAFEESKDNTIPLLYGILAHFLRGTKDGIQNAFLKGPSLQPSDPSLGRQPSRRKPMDDHLRKEEQKSTNIEDLHVSQAVNR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MANERLRVLEEVEKEIAMVLQCAGNIVLELSKDKQIANWKEVERQLLQFQSSTNRVESELSAQIRYLTQVPEPEPSVTSSFWPGTTEEQGERFPFSTKSHQSMKQRLVHVPHYEKQLYVSTDLH