lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Endosome membrane. Midbody. Note=Accumulates transiently at the abscission site before abscission occurs. Colocalized with GRAF1/ARHGAP26 and GRAF2/ARHGAP10, RAB8A, RAB8B and RAB10 on endosomal tubules.
Domain:
The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab13 and Rab15 (in their GTP-bound forms); The C-terminal coiled coil part contains the plexin-interacting region.
Sequence:
MASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEPGGGLPQYHKIKDQLNYWSAKSLWTKLDKRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVELALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVTFTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGKFVPEGFKVREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKATGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDWPDTNRLLGSANVVPEALQRFTRAAADFATHGKLGKLEFAQDAHGQPDVSAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAESLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVRDLYDVLAKEPVQRNNDKTDTGMPATGSAGTQEELLRWCQEQTAGYPGVHVSDLSSSWADGLALCALVYRLQPGLLEPSELQGLGALEATAWALKVAENELGITPVVSAQAVVAGSDPLGLIAYLSHFHSAFKSMAHSPGPVSQASPGTSSAVLFLSKLQRTLQRSRAKENAEDAGGKKLRLEMEAETPSTEVPPDPEPGVPLTPPSQHQEAGAGDLCALCGEHLYVLERLCVNGHFFHRSCFRCHTCEATLWPGGYEQHPGDGHFYCLQHLPQTDHKAEGSDRGPESPELPTPSENSMPPGLSTPTASQEGAGPVPDPSQPTRRQIRLSSPERQRLSSLNLTPDPEMEPPPKPPRSCSALARHALESSFVGWGLPVQSPQALVAMEKEEKESPFSSEEEEEDVPLDSDVEQALQTFAKTSGTMNNYPTWRRTLLRRAKEEEMKRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQSSSPEQQKKLWVGQLLQLVDKKNSLVAEEAELMITVQELNLEEKQWQLDQELRGYMNREENLKTAADRQAEDQVLRKLVDLVNQRDALIRFQEERRLSELALGTGAQG
The following text describes a protein:
Function:
A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection. Required for aha-1 nuclear localization. Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression. Role in life span extension is dependent of temperature. Not required for survival in anoxic conditions. Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3. May be involved in manganese homeostasis by repressing divalent metal transporter smf-3. In a low oxygen environment (hypoxia), induces fmo-2 expression in parallel with nuclear hormone receptor nhr-49.
Subcellular Localization:
Nucleus.
Sequence:
MEDNRKRNMERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLENNLDNEITNEVWTEDTIAECLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLTGRALRDFLHPSDYDEFDKQSKMLHKPRGEDTDTTGINMVLRMKTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFMQGITIPAGQGTTNANASAMTKYTESPMGAFTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKSMKELFAKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSMPAGMQVDIKKEVDDTRDYIGRQPEIVECVDFTPLIEPEDPFDTVIEPVVGGEEPVKQADMGARKNSYDDVLQWLFRDQPSSPPPARYRSADRFRTTEPSNFGSALASPDFMDSSSRTSRPKTSYGRRAQSQGSRTTGSSSTSASATLPHSANYSPLAEGISQCGLNSPPSIKSGQVVYGDARSMGRSCDPSDSSRRFSALSPSDTLNVSSTRGINPVIGSNDVFSTMPFADSIAIAERIDSSPTLTSGEPILCDDLQWEEPDLSCLAPFVDTYDMMQMDEGLPPELQALYDLPDFTPAVPQAPAARPVHIDRSPPAKRMHQSGPSDLDFMYTQHYQPFQQDETYWQGQQQQNEQQPSSYSPFPMLS
The following text describes a protein:
Function:
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Sequence:
MQGTACASAYARYNCRQKQYHGMRNAVQFVFPLLRKVLSFARTPPREQLLSMLVGAPYSLAHEGPLTCTHLHAFVNTPEGELLRMFEGCIAERLAAPPSQHVMKMWSPDLQEYYKRATAKACVDASGERKPQRFEAGLSACSVFSLGVQNHTVESDLWGEFGSGHTHQGTYLNPFGDQAAREGEEDIASDWCRLIDMYSLFLPDRSPLHELENLPQEIGIGELLLSLLKHVYMTDIDIKTIVDVGGGNGFLAAQLAERLGCESFVVDPFTPKHAIDNANFPHWTVGARVRQRRERRYPLHRISKRLQDVDWGNTHIDFDSCAVVAKHLCGTSVDSCLRHLMASNKLPRVLVVVPCCFNKGRYAEYCNPGFLSHVADVEGELSWEQCTRLTDWNKSCYQQAGNPLSCSSCCSCCNGSYDRRAGEKKVSRKRKMEHFLPCMDDIATLVEVIINYGRVLWLREMGYQTSVVEYVPRCVTPKNRAIVAVRRERSSDASLEITMSDTHPSLPAFQ
The following text describes a protein:
Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. As part of the Notch signaling pathway, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm.
Subcellular Localization:
Nucleus.
Domain:
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG); The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
Sequence:
MAVQGQRFMTKTQHYRKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANPQSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQLGHQLKDMKQEEEIIDMAEEPVNLADQKRSKSPREEDIHHGEEVWRPW
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVYWMIKLYFRYSLAIGITSQQFSNRKFFSTLFSRTYALIANIVTLIMLPIVMWQVQLVFQQKKTFPKLILITNNVREAVSFLVILYTVLSRGFRDTAFKEMQPLLLTLFREEKRCGFKGIGGVRRSLRILLFVKFFTLSWLCVTDVLFLLYSTDALIWVNVLRFFFKCNTNNILEMVPMGYFLALWHIARGFDCVNRRLDQIVKSKSTRKHRELQHLWLLHACLTKTALNINKIYAPQMLASRFDNFVNGVIQAYWGAVFTFDLSTPFFWVVYGSVQYHVRCLDYYLIDNMCDVAVEYHDSAKHSWSEVRWTKEISSYVIYANSTKLQLWSCGLFQANRSMWFAMISSVLYYILVLLQFHLVMRK
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MAEIQPPHHILHPHQPQPQQPSYQAVKAATAATAGGSLLVLSGLTLVGTVIALTVATPLLVIFSPVLVPAAIAVFFLVLGFLASGGFGVAAVTVLSWIYRYVTGRHPPGADHLDSARMKLASKAREMKDRAEQFGQQHTGQQGT
The following text describes a protein:
Function:
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
Sequence:
MVEFGVVRSTDEAVEEIMRIHRSLPPRPAVDEVLAAKALIRNVEKEDQARLEAITRQTKSPNVPEELFLILLEMQKNCVYFQSKEQKREAFKLLDLESVHALFDEFIQRASNCLSSTSSKLNDKTTLSNALPHTAATPPPSNNSFTAATPSSFRELASERPLFSRDDSYVKKAKSSFYANSTDGLGISMSSSPHILDSSLKSGGATAAVQDDEKLSLIKLASIIEVSSKKGTRDLNLQGKLMDQIDWLPDSIGKLCSLITLDLSDNRIVALPDTIGGLSSLKKLDLHSNKIAQLPDSIGDLLSLVFLDLSANQLSSLPATFGRLVRLEELDLSSNHLPSLPDSIGSLISLKKLNVETNDIEEIPHTIGHCSSLKELRADYNRLKALPEAVGKIETLEVLSVRYNNIKQLPTTMSSLANLKELDVSFNELESLPESLCFATTLVKMNVGNNFADMRSLPRSIGNLEMLEELDISNNQIRVLPDSFRMLTRLQVLRVDQNPLEVPPRHIAEQGAQAVVRYMADLVEKRDVKLQPEKQKKSWAQICFFSKSNKRKRNGMDYVKA
The following text describes a protein:
Function:
May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MKPPSSMQTSEFDSSDEEPIEDEQTPIQISWLPLSRVNCSQFLGLCALPGCKFKDVRRNIQKDTDGGTPDITSCCEIMEELEICLKNNRKTLIHCYGGLGRSCLVAACLLLYLSDTVSPQQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRNSLSRSVSR
The following text describes a protein:
Function:
Has a role in eye development; Calcium-regulated non-lysosomal thiol-protease.
Miscellaneous:
MISCELLANEOUS: Although homology to other calpains is high within the protease domain, the lack of calcium-binding sites suggests that this protein is a protease that may not be activated by calcium ions.
Sequence:
MGTISSVLQWSCTKCNTINPTESLKCFNCGTVRKVFPQQQQQQHRSSSITASWTADDALEQEQAEKGQERDKEKGRAAVARSEYKHVYKSLLRGCLKRPQRNSQNLPANCVDCEDTRKYIKSSIELYRHFSNPALNRRWVCHACGTDNSSVTWHCLICDTVSYLAPIYKDAIAADRGQDLAGSLGNRGELLAADHSHPHHHHHYLHQELEEQHQHQLHSQHLHKRHLKGRSASGSGSGPGSGSGLRRTQSLSTAIDKSASGRSCHICYANNQSKDIFNLPQIKPAPQLTGIPPVAACSNSRFAIANDTFCRRKQNNNNKNQNHKVVRESGAKRKYNFTITTLSRSAAKDAGHGQMKPLRQVVNLNLNLQQEPQQKSPANPQQLQRKTQREPAAVSMNPTQFTIPRNGVFIAVNEWSEPMASSSSVSSSSNHHHHHHSNSNSNSSGNSNIINNNSSSSSGSNKLYENECVALAQQQLRAAAAQAAQAAATAVAIASSPSAKAMAEPAPTATMPIYAQVNKQHKLKKKQQIASESQTNNNTGSGEIADAVSESLTAGLGTSTDGSGEASESESQVEEHSIYAKVWKGPRKATESKIMHDPGSSSRLSGAASAAAGTASAGAIAAAVGAAAASRHDNKTQLGNGSRSKMWICIKCSYAYNRLWLQTCEMCEAKAEQQQQQLQLQQQQQQQQQHHHHHLQQQQAEAPRDEPWTCKKCTLVNYSTAMACVVCGGSKLKSISSIEDMTLRKGEFWTCSHCTLKNSLHSPVCSACKSHRQPQLSMAMEAVRERPDGQSYEEQDAAAVGGGGGSAHQSGANEVKAPTALNLPLTSVALPMPMLQLPTSTAAGLRGSRSPSPRMQLLPSLQQQRNSSSSGAIPKRHSTGGSIVPRNISIAGLANYNLQQGQGVGSASVVSASGAGSGAGAVGASTSTKKWQCPACTYDNCAASVVCDICSSPRGLASAVLGEALGRKSVRVALTPADIRQESKLMENLRQLEETEALTKWQNIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQGAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVYSQAKRKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQGHRLLKLRNPWGHYSWRGDWSDDSSLWTDDLRDALMPHGASEGVFWISFEDVLNYFDCIDICKVRSGWNEVRLQGTLQPLCSISCVLLTVLEPTEAEFTLFQEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLVEHSKRQVRGFVGCHKMLERDIYLLVCLAFNHWHTGIEDPHQYPQCILAIHSSKRLLVEQISPSPHLLADAIISLTLTKGQRHEGREGMTAYYLTKGWAGLVVMVENRHENKWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSRGLHDWGPPGATHCPPIENVHGLHAPRLIT
The following text describes a protein:
Function:
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit (By similarity).
Sequence:
MFWKFDLHSSSHIDTLLERDEVTLKELMDEEDILQECKAQNRKLVEFLLKAECLEDLVTFITEEPPQDMDEKIRYKYPNLSCELLTSDVSQINDRLGEDESLLKRLYAFLLNDPPLNPLLASFFSKVLSILISRKPEQIVAFLKQKDDFVNLIIKHIGTSAIMDLLLRLLTCIEPPQLRQDVLNWLNEEKIIQRLVEIVHPSQDEDRHSNASQSLCEIIRLSRDQMLQVQNSSEPDPLLATLEKKEILEQLLSNIFLKEKNESAIVSAIQILLTLLETRRPAFEGHIDLCPPGVNYSAFSVNKNVLAAIQERLPSFHQLLLDPPKTGVMKTTWGILDPPVGNTRLNVIRLIASLLQTNTHSINEELIELNTMGVILDMFFKYSWNNFLHTQVEICLALILASPGDSPEHSTISEQNSTGDHVLLKHLFLKCHLIDRILEAWAMNEKRQSEGGQRYGYMGHLTRIANCIVHSIEKGPNSVLAHQLIKDLPTDAQERWETFCTSSLGETNKRNTVDLVTTRHIHSSSDDEIEFKDPGFSQDSAIQQFGFNDEKFADQDDIGNVSFDRVSDINFSLNANESANIALFEACCKERIQQFDDGGSDEEDIWEEKNIAFPQETQRRSSSGSTDSEESTDSEEEETVKQGLFESSTVNHEDKMEVDANEASNWTANFDIPMETAHVASLDSVGSDAWSTEEPLSSKETGWASFSEFTSPINTKETIRSSSPVEMETSTEPVDPLSVNASAQTEVTVAMDAVSDGDEEGENADQMTETVMNGSMKETLSLTVDAKTETAVFKSEEGKLTTSHDSACKYGVVENFDSAMENAPPTQPSSSSQEQRTSEQIVLDGASANGPV
The following text describes a protein:
Function:
Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MREPSSAVAGAPQFVLVQEMTELLSLVSVKGPAKVSSVVPVSTRWLVRGAFALALVAAAAWLGYMVTFRRGLDHLHAAAQQRLTVEAARLDGYLSRFEYLPSLLETSPSVFRLLEAPSDPALQQNVSLYLKSINLLAGADNLYVLGVTGATLAAADFDQPGTPFGENLSYRPYVSEALSNGRGAFFGVGITTARAGYYLSYALKDGGTTKGIATVKVNLDSFERAWRSTDNDILLVDERKVTILAARDEWRYRPMAPLSVPTRDDIARFKPYGNHDLVPLGWTLVDQSENGTARIIAENGTAYTVSEVPINRGLWKLVLLDDEAPTRQTALIIGIISGLAALVALLALGLVEQRRREIKQRLASQAALQAANDMLETRVQERTAELRAAQDELVHAGKLAALGQMSAGIVHELNQPLAALQTAADNAVLLVDRGSIGDARGNLTRIGELVRRLGRLTSQLRVFAYKSSSPLGAVSVEHAVAESLKILAGRVKEGGVAVATEIDAKLFVVADQTRLEQLLCNIVANALDAVEGVERKSILIRAGREEAQTVRCRIVISNSGPTIASDVLQRMFEPFVTTKPAGKGLGLGLMLSNHIARSFGGELHARNLTPDGAEFVVTLPLAEIAEAASHG
The following text describes a protein:
Function:
DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSSNEQICLDEDWIQKFGDREIEFVDEAQKSEVDETEKSIKRFPLSVLQRKGLALINLRIGVVKTGFGGKTIIDFEKDPAFSNGEELPANSFSPGDVVSIRQDFQSSKKKRPNETDISVEGVVTRVHERHISVALKSEEDIPSSVTRLSVVKLVNRVTYERMRHTMLEFKRSIPEYRNSLFYTLIGRKKADVSIDQKLIGDIKYFNKELNASQKKAVKFSIAVKELSLIHGPPGTGKTHTLVEIIQQLVLRNKRILVCGASNLAVDNIVDRLSSSGIPMVRLGHPARLLPSILDHSLDVLSRTGDNGDVIRGISEDIDVCLSKITKTKNGRERREIYKNIRELRKDYRKYEAKTVANIVSASKVVFCTLHGAGSRQLKGQRFDAVIIDEASQALEPQCWIPLLGMNKVILAGDHMQLSPNVQSKRPYISMFERLVKSQGDLVKCFLNIQYRMHELISKFPSDTFYDSKLVPAEEVKKRLLMDLENVEETELTDSPIYFYDTLGNYQEDDRSEDMQNFYQDSKSNHWEAQIVSYHISGLLEAGLEAKDIAVVTPYNAQVALIRQLLKEKGIEVEMGSVDKVQGREKEAIIFSLVRSNDVREVGFLAEKRRLNVAITRPKRHLCVIGDSNTVKWASEFFHQWVDFLEENAIVMDIDATMFE
The following text describes a protein:
Function:
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQLYWYTCGEGDCDLVLLHGWGLNSGVWHCIIDRLAPHFRLHLVDLPGYGRSQDYGAMSLADMAERVAQQAPKQALWLGWSMGGLVASQIALSQPECVRGLITVSSSPCFTARDEWPGIKPEVLAGFQHQLSDDFHRTVERFLALQTLGTESSRQDARLLKSVVLQHQMPDVEVLTGGLAILRTADLRTALAGFTLPFMRVYGHLDSLVPRKVASLLDSAWPQTQSVVMQGAAHAPFISHPNDFAKLILNFAEENKK
The following text describes a protein:
Function:
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MPCREIFLLWILVPIASSSDHITFFGRYACNVDFKTDYCTPDTYVGRAFYYGLEDGGGITTNGTFVNSDITVEFFDPTVQGNFSIGRQDGNYMSSMLDIMLADTKKNDGLLGVVGVENDCKEIAALAQAYDASSLLVNCEDQVGESQMPSSTALQMSSTQGGKYRAFAKLAKSVGWNNLAVINFVEDGPADISYHDQLLDALSAESISLDFVKKGGFSSTITSAMFTGLESVIDVILETYMKTRIYVIVLDLPVSGTFFMNAMSTMGLLETGKYFVVMMSSIESDAANYFGFNVNRGNMIFKTIDYGISDADIRQYYRSFMYFTDVPHYTKDFSDEWTSFQKRVDGDASKTFCPPMCNTKAKGIANNDPWSDDAYWYSESPSIVDAYDLGRLLSETVKVHGASLLRDPESLVQTMSGRGVTSLLGYVTKFNTNGVSQREYILWAPQQASSSNGPIPLPEWATLAARMLPDGKGNYSIIWKNLTQLGIFNGELPQSKPECGFNNELCPAGIRNLSELEIIVIAVCVVAILILVGVIAYIARWIAYERRLESSYFLVHRKHVQLVDMTKFGSSRGGSMIQSAMSMRSQYEDSGPVGGATMNFYTNGIRKAAIRRNQMQRSDKGPAANRDEWLEIVDWHLAKYENTLVTVRKINKTQLKLTREMKQEIDLLMNETHENLNRFFGLINESDLIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESKPDDLLWFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAPYPLASVVEKCWVEDPASRPSIKKVRELLKPLSKGLKGNIADNIMNLLDRYRNNLEDVIKERTEQLEDERKRNESLLLQLLPKSVANSLKNGQPVDAEFYDSVSIYFSDIVGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNSYLHAGEVASASLELLDSIKTFTVSHCPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQISSDAYELILKCGGYVTEQREKIVLKNKLEVMTYWMNDYSKDARLARLVAHQEKFPHLEHLIHKFNKGVR
The following text describes a protein:
Function:
Involved in the degradation of prenylcysteine. Cleaves specifically the thioether bond of S-farnesyl-L-cysteine and has no activity with S-geranylgeranyl-L-cysteine. Also recognizes N-acetyl-farnesylcysteine and may have a role in deprenylation of farnesylated proteins.
Miscellaneous:
MISCELLANEOUS: Plants with decreased levels of farnesylcysteine lyase exhibit delayed germination and hypersensitivity to abscisic acid.
Subcellular Localization:
Lysosome.
Sequence:
MKDFPIAISLLFALLSPVLLPCSGDSTGGVEDDSPATVCIVGSGIGGSSVAHFLRNYSVSTGLNQAKILMFERHEIVGGRMRTVTVAGDTFEAGGSILHPKNYHVKDFVERFNLTVRLPTPIEESSAIGIWDGKRFVVKTFGSGTKFPFLDTIVSWVNDLYLFLRYGLSLLRMSSFIENTVDNFLKYYESLESRPIFDNVEGMLKWSGLYNLTKLTLQEKLSEAQLSPLLVNELVTVITRINYGQSVLISGLAGAVSLAGSGGGLWSVEGGNWQMAAKLINHSDVTLHLNEKIESISYLENHYELKSTKGNSYKCDVTVVATPLDEVDIQFSPTISIPKRELQHTHTTFVRGLLNPGYFGMKSLSDVPALVGTLEDPLIPFSCISILRKYSKTDMTYKIFTRQPASDSLLDELFSRRTETVRIDWGAYPKYHAPEVFAPFILDDHHLYYVNAFENAASTMETSAVAGENIARLIISRFMTKESLSSSDKRSCSSGLHSDS
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MITMNNTATANTLGGITFSDLTGATTATGQGTGGLQLVQLSQVMPDQNSQQLFMQSLQQQLTGGAPAIQVIPLGALPQQTLSLAQGPHPGATLQAAPQQQQFVQYTLDGQTLLYQALPTPETAYQSVNLPIVQLPATQTLGTAGTVPTYGNISSLQGGPITFTQIPTVTQAIPQHHHPQQHLQQQQHHLQTAATLDASAFQNIVTGPVTLTPTATVVPVSQPQQLPLSGPVTTVTIGQPPQQQIGIGVANLPSSNSSSNTTPTTVVNSPAIVTPPECTVLATTSGGGGSGSGLEMEQEPLYVNAKQYKRILKRRQARAKLEAMGKIPKQRPKYLHESRHRHAMNRVRGEGGRFHSK
The following text describes a protein:
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Together with other chaperonins, contribute to the regulation of gene expression by modulating the spliceosome function on pre-mRNA splicing post-transcriptionally by acting as a co-chaperone of Hsp90 to control levels of LSM8 (By similarity). Required for the biogenesis of tubulins and for subsequent microtubules (MTs) organization and dynamicity. Necessary for tolerance to NaCl salt stress. Involved in the process leading to microtubules dissociation in response to gibberellic acid (GA) probably due to the DELLA proteins-mediated translocation of the prefoldin co-chaperone complex from the cytoplasm to the nucleus. Prevents cold acclimation (e.g. 7 days at 4 degrees Celsius) in a DELLA proteins-dependent manner by promoting nuclear proteasome-mediated HY5 degradation, thus modulating the expression of several genes and reducing anthocyanin biosynthesis, but seems not involved in constitutive freezing tolerance. Contributes to the GA-dependent regulation of PIN2 trafficking at the plasma membrane, thus influencing auxin flux.
Subcellular Localization:
Cytoplasm. Nucleus. Note=In the presence of gibberellic acid (GA) and at room temperature, the prefoldin complex stays in the cytoplasm and is functional. But in the absence of GA or in response to cold, the prefoldin complex is localized to the nucleus in the presence of DELLA proteins, which severely compromises alpha/beta-tubulin heterodimer availability, thus affecting microtubules (MTs) organization. This changing subcellular localization follows a daily rhythm coordinated oscillation. Interacts with LSM8, a specific subunit of the LSM2-8 complex, which is core components of the spliceosome.
Sequence:
MASSSSRGEMEKMGIDQLKALKEQADLEVNLLQDSLNNIRTATVRLDAAAAALNDLSLRPQGKKMLVPLTASLYVPGTLDEADKVLVDIGTGYFIEKTMDDGKDYCQRKINLLKSNFDQLFEVAAKKKSVADEAGMVLQAKVKQLTAATTS
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MFFALFGYGQPATHYVSSVANTRRDFYGKLDFHRQGLFDHLIGSSAQELLYFSGGGGGSTGSSSMKTALNKIFDQYREDPKAEPDLVGIEGTMKYFGDLNVDLEGLESFAAHEIVQAPAMGELSREGFVNGWQERNCDTIEKQKAYIKNLKSELPGNRELFDRVYKYAFTIAKAGNSKQAALEQAIAFWDLLFASPLSAIKWSSASTPWLDWWKDFLTTSFKKSVNKDMWNETLKFAKLTLADEAMTFWTEESSWPSVIDDFVEWVKTEKRGGSKEEPMDEEY
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MKRQASCNDSPSQEASQSKRLAQARLSFENTLVLPSADIQRFKSIDDQINTLPPSQLELTVEPTSDFTPEYSNSIQDGSVYGVYEESIEEDMDDLTTISQRSYSEQLQHMISNVLPEESHLLDDQHMSVLRWFDRLSEGSQIVMFRLLNRRTRKYVYINKIKLHEDEDINQILAELVNADYIVLDGPSTLEEWVDLLKKDQLVDLAKHHRVATSGKKLAVLRESFLATVNNQLNLDTFTKLGRISTLEKAHERLIKLIQEIVGPLLKVTELARSAFYRLFVIYNRTTMWPKHDSFLTNSILCNLSASNESKKSFAQYTVHRTSLVWSDKAEFELYFTSLKVEHEMAELIADKPAESQLVEFCNKAAILFDLWLLIIAEHPSHVTGIPWFMVFTHGKLPAVLTRIVASYASILIQLKKPHDAIQVLDGLLSQRILYQRRRGSWYDELVKLLERHLTPNYDLAHRSSILRRLCRISGSKQAGIPALWNIDSLRAVPSSRMSAYKLSNETGGKAIYLDENHTPMHVEELVLQHYAKQGWKGIHAENTAPLDLYTEYFFTARQESIETRIQAIKSGEFPLIIRQVVDKEQPRNTQCVGK
The following text describes a protein:
Function:
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Sequence:
MNFKLYLISDRKIFPNKETFFRAVEIALKAGIKALQLREKDLTAKELYNLAKKLREITKRNDAMLFINDRIDIALAVEADGVHLPQSGFPPRIVREVWKDRFLIGVSTHSIDEAKEASEWADFITFSPIFHTPSKAHYGEPQGVEKLKEVKESVKCKVFALGGIKLENVHELIPYCDGIALISGILAQRNIEGTVKKFKEILGENI
The following text describes a protein:
Function:
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Domain:
Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).
Sequence:
MGRRKGKKSAKETGVLLRRHLRYRLREGCFILALAFSAFLFIALLSYHRSDPGWSHSIVVKHVANLTGEAGAWLSDFTLYMVGYLAYIFPLMVAFAAWVFFRNRHEEQDIPTKWPLLILRAVGFLLILLAGSALAAIHLGTLDANLPYNGGGIIGVVMAKSLFPIFNTAGTSLILIAFLLIGITLFTGLSWFQFLELLGKNAIKFTKFCAIRLGAISWKDLFLSLLPSQDKREAVTVPKIKRVEPDLVPDALDMISTPKIAERPKLEIIDHEFKTPRFKGSAILPELSLLDKPSQDHTLSYSEEELQQKSREVELRLADFGIQAKVVAVHPGPVVTRFELQLAAGTKASRVTNLAKDLARSLSVISVRIVEVIPGKSVIGLELPNKNREVVTIYEVLATKQYQNARSSLTLALGKDIGGHPVIVDLAKMPHLLVAGTTGSGKSVSLNAMLLSLLYKSTPQQLRLILIDPKMLELSVYEGIPHLLTPVVTDMKDAAAALRWCVVEMERRYRLMASLGVRNILGYNAKVKEAIEAGAPLLDPLQAAAEGKPPELQELPQLVVIADEFADMMVVVGKKVETLIVRLAQKARAAGIHLIFATQRPSVDVITGLIKANIPTRVAFQVSSKIDSRTILDQQGAEQLLGHGDLLYLAPGSGVPVRVHGPYVKDEEVHRVAEYLRESSEPNYVEGILDEMGAQDLSGFVEAALGGGSEEGGESDPLYDEAVEAVIRSRRVSVSSIQRRFKIGYNRAARIVEAMEAAGVVSPMENNGAREVLAPSKE