lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates basipetal PIN proteins (e.g. PIN1) polarization to establish inward auxin transport from the L1 surface of incipient organ primordia; this process is essential for the progression of flower organs development. Recruited to the plasma membrane by PINs (e.g. PIN1 and PIN2) and, in concert with AGC kinases-mediated (e.g. D6PK and PID) PINs phosphorylation, maintains their cell polarity (apical or basal) through limiting lateral diffusion-based escape. Influences cotyledon development by regulating auxin distribution mainly in the provascular tissue. Plays an essential role in auxin-mediated organogenesis and in root gravitropic responses through the control of PIN proteins (e.g. PIN1 and PIN2) polarity in the root tip endodermal cell layer and in shoot epidermis.
Subcellular Localization:
Cell membrane. Cytoplasm, cytosol. Note=Observed in the cytosol and in apolar aggregates close to the plasma membrane in root epidermis and lateral root cap cells when PIN2 is absent. PIN1- and PIN2-dependent polar localization at the cell periphery almost identical to PIN proteins polarity, in the upper side of the plasma membrane towards the tips of cotyledon primordia in the protodermal cells and in root epidermis, and in the basal side of provascular cells, root stele, pericycle, endodermis and cortex, and in radicle tip cells; this localization is enhanced by PID. Weakly observed in the cytosol of root tip quiescent center (QC) and columella cells, sometimes close to the basal side of the plasma membrane. Apical and occasional cytoplasmic localization in root epidermal cells.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MKFMKLGSKPDSFQSEGDNVRYVSSELATDVIVIIGDVKFYLHKFPLLSKSARLQKLITTSTSSSNEENQIHHHHHEDEIEIAEIPGGPASFEICAKFCYGMTVTLNAYNVVAARCAAEFLEMYETVEKGNLVYKIEVFLNSSILQSWKDSIIVLQTTRALSPYSEELKLTGRCLDSIASRASIDTSKVEWSYTYSKKKNLDNGLRKPQAVPRDWWVEDLCDLHIDLYKRALATIEARGNVSADVIGEALHAYAIKRIPGFSKSSSVQVTDFAKYRALADSIIELIPDEKRSVSSSFLTKLLRASIFLGCDEVAGLKNRVGERLDEANLGDVLLYDVELMQSLVEVFLKSRDPREDDVTAKASVAKLVDGYLAEKSRDSDNLPLQKFLSLAEMVSSFPRQSHDGVYRAIDMFLKEHPEMNKSEKKRICRLMDCRKLSAEACAHAVQNERLPMRVVVQVLFFEQVRANNNGSSSTGNSTPEVIPASRSTNTTDQEDTECWDTEDIKALRGELANLRLAKNQQESHNQGKLMKGGGLGVSRVFSKLWSGKERSGDMISSSGTSSPGSVNDDSKSSSSTSKKH
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQVQQPQQIQQQHLQQQQAQQHQQQQVQQHQQQQQQQQQQQQIYQQIVNQPVNNVHQLPSLQQQQLLEQYDELLKQVSLIRSNVSDFFNSFIEDAKQQQTIVNKEEMKQKLKKSMDLVLGSISSIDKVSKRISSYSFQIASSNFSTQEASWAYSTGIYDNRNIKVQLEIRNENYWRSQTSYKSSLASSNLENKLKDLFPIIFQEDEESSSLSKKRKQISSLTSNSLSTTTITTTTTPSPLFKLPSTPPTLLLSGTISPFYDYFAQIERVIHSIRQESALEIFEIQKQSSGAPKGLFVECPDVFKCLICFGIPNDRKDCFTIDRISFFGVKENFDSLWASSKYNIFKKISENSFEAISYYSANPNGGSILKCILSWIWSFRGLFLEECKGCQDILHLDSPQYMYLPPSFRTFDNYTPYHPSCYQNHLLSCNSFSSSTSSSIQQSPFSPLNK
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere. Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MAEGARVRNRHQQVMETVRSARSRFEAWERSCEKRMDELQEMSRSVSRGGHEESEQLKQHLREISEQKIHKEKEITARKQQHETLKKMIEQANEKKIYLAKRLELLKERREGCAHVAEESLKDLEERVRRVQQKVNAQKIARKFYNDILGIRADFASGIKITFTKVNAKNPDHEYSCTIRLDKHTNKYAMLDCVPYVKRSVDLLDDLNITNEFFEFLRLMRREFERLAEESDARSVRLKDLHTFQSVHGGHGARFLRAAATLVPAANLWIPARDPGLGFSPGEAMQLKRAYDKIYDKYERDKARRIENAEKLFEEHKLRTAAYSKATESLVETLREENEMLRHLVKESQVEETMVRLKELEKENALYRNQLLMAQARDCHSDRTREDRYKFLQRLFQLLSDMQITEVEDDNSAAFVFLHQSTGLKFSLEPVVDPDTARICGGDREVKFTSLALGSLRYIAPEWMRESITFSISQAPVFFRRIQTVTRGRS
The following text describes a protein:
Function:
Seed storage protein; (Microbial infection) Involved in tobacco mosaic virus (TMV) replication. Required for endoplasmic reticulum (ER) aggregations mediated by TMV main replicase (P126) upon viral infection.
Sequence:
MAITNKLIITLLLLISIAVVHCLSFRVEIDEFEPPQQGEQEGPRRRPGGGSGEGWEEESTNHPYHFRKRSFSDWFQSKEGFVRVLPKFTKHAPALFRGIENYRFSLVEMEPTTFFVPHHLDADAVFIVLQGKGVIEFVTDKTKESFHITKGDVVRIPSGVTNFITNTNQTVPLRLAQITVPVNNPGNYKDYFPAASQFQQSYFNGFTKEVLSTSFNVPEELLGRLVTRSKEIGQGIIRRISPDQIKELAEHATSPSNKHKAKKEKEEDKDLRTLWTPFNLFAIDPIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPYKFQRGQQQWPGQGQEEEEDMSENVHKVVSRVCKGEVFIVPAGHPFTILSQDQDFIAVGFGIYATNSKRTFLAGEENLLSNLNPAATRVTFGVGSKVAEKLFTSQNYSYFAPTSRSQQQIPEKHKPSFQSILDFAGF
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MHVTLVPLKTLVSLIHLFFFQATSFSFATFSATTTTMADHHHHPTSLSQTQTTPRTTTSSSLLRKLRHHVANSNQLFGVLTLLITGSILLLLTGLTIVGSVLGLILFAPLIIVTSPIWIPLCAVLFLVTAMFLSMCGFGIVVLAVLTWMYRYFKGLHHPPGSNRVSHALNRVKDRAGNLNSKGLDAAAPGA
The following text describes a protein:
Function:
Clp protease adapter that facilitates CLPS1 recruitment to ClpC chaperones thus forming a binary adapter for selective substrate recognition and delivery to plastid Clp protease system (CLPC).
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MVQSQSLSTLTICGSVKVSSLLRNRLNSVKASSLIGDRCVSCQFLRKSPSFRSHWKSLKQRNLLRVEARWPFQGGGEQGLDPSSERSESANEDILIFFFQLDLATRVQYAMNLEQYDIAQQLREKLTEVEEESIRLQEGKRGSSAKSEAQDKGISIIRLRADLQNAIDSEDYGLAAKLRDEISKLEAESLAVSAKALAFEKAEYAFRLGQKLRHKTFGYRAVVCGMDPICSESSSWMEAAEVEKLPRGSNQPFYQVLVDVRTHPDLLVAYVAEDNLLAPEKPDKERFDHPYISFLYYGADTAGDFIPVKQLREKYNRPRHEVPFDSQDED
The following text describes a protein:
Function:
Intercellular signal essential for a variety of patterning events during development.
Subcellular Localization:
[Warthog protein 8]: Secreted. Cell surface. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells; [Warthog protein 8 N-product]: Cell membrane; Peripheral membrane protein; Extracellular side; [Warthog protein 8 C-product]: Secreted, extracellular space. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells.
Sequence:
MNYLLLVSGLLSVWQPVFGSRCGESTIPFSLEILPSGHPVLGCARPTCFGWHPKGYQLPTTAKFSRLNRKLDGFLRDDSLFTYPFETDSSKIYKVQNSTCEPGFQSSKCDSKDQWVGGIEPETDAFQDVAYQCCTYAPLRESTDRNIATVSAGEIVIGGEVYQNESQYAFDYISNIEKSMDENGEVYYEVNIRRFACLDPHNADRRIDEVWSSENTIRKVNGQKPIAQQAPNVAVNAPIEAGTFDGEVVDGQTVVIEEIIAQQGFIVENETTVAPFAGPFQAQGFQPRFGAPQGFQPAFQQPPPQQFFPQNFQPVVQQPVQFPAQPVGYAPYAPAGWQLHYCFPADAEVNVYEKGVKRMDELEVGDWVQALHGKETTYSPVKYWLHRDPEQEAEFVEFLLENGESFTLTEKHLVFATDCQQNVKNLDDLNPTSTGKINIGECFFMAQPENASKFQKVQILDIQRVRKTGIYAPMTSLGHLLVNQIHTSCHSEIDHHLLQNSFFKHVLKLKNRISKYFWNEESNTEGNIGTSLNFLIEIFELIVPSKMISY
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
CPEFLQQYNHYTSNVEIFKLQPYKPGKELAELVVFMAQNISYCYPAYLSNFPQVVKDLLSCNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLCCHDKLLQKTLYTYIVTDIKNINAKHKNKVDVVLDSNATAAKMSLDVMIELYRRNIWNDTKTVNVITTACFSKVTKILVAALTFFLGKDEDEKQASDSESEDDGPTARDLLAQEESSPNKKKLEKAMKVLKKQKKKKPEVFNFLAVHLIHDPQDFAEKLLKQLECCKERLEVKMILVGIHKLFLFNFYHFLRRFLQPHQREVTKNLLFAAQASHHLVHPAIIQSLLMTVANNFVNDKNSGEAMTVGINSVKETTAQCPLAMTEKLLQDLAQYKTRNDNNVMMSARTLIRLFQTLNPQMLQKKFWGKPTEASVEARVQEYGELDAKDYIPEAEVLEVEKEENAENDEDGWESTSLSEEEDADGEWVDVQHSSNEEQQEISKKLNSMPMEEQKAKTAAVSTNFQKIRMAQMRKELDAKRKYIEIDSDEEPRGELLSLPDIERLHKKPKSDKETRLATAMAGKTDRKEFVRKKTKVNPFSSSKSKEKKKQKNFMMMWYSQNVWSKNKQKQLALRDAF
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRFFVSGYTSDSSSEEEDLLSTSEEELLSSSDEGEDNESDSSFFGEDDDESEESSSDDEDGRPSGPAYFLKKSFLKGAGGDDSDSDSDDEGRKVVKSAKDKLLDDMKSSIEIINSNKYNNNWSIVLGEFDKFGRFLIRCNQTNLGTPKFYIKLLTSLDNSITETSNNERDDKTLKADEARAFNTLRQRIKKQIREFQVYYDLYKENPEEFDENEDEPLESVQAGLNDNVKNEADNSNVGALASNRVLSPIFHTLKTISESRGKKNIDKLEQIATLEKLLEANVSKSSPFELISIYQMLLSVRFDASSNQAFMPLEQWQKNEQDLGKLLDLLEANVDTYQVSELGSTTDDIDIEPVANAQGVKVIFGSITSSIDRLDDELTKSLQHTDPHSTEYVERLKDESTIYNLIVRGQAYVESITPEDVKYKSEQLARIVLRRLEHIYYKPKQLIKANEEEAWRNIEYNSSIVSKGSSVDEVIDQLTEFLQKQQKNKTYGKHAILFSIYYYAVNSQYEKAKELFLRSQFYSNINSAESSLQVQYNRALVQLGLSAFRAGSIEESHKILNEIVNSQRSKELLGQGFNSKFPNQATVLERQKLLPFHQHINLELLECVFMTCSLLIEIPTLAAIANNHKDSKRKNASLKSFKSKLDFHDRQFFTGPPESIKDHIVHASIALQKGDWLKSYNLLSSIKIWKLFPDNDKLLAMMKNQLQIEGLRTYIFTYKSVFKKLSIEKLQQIFQLSKDEVVSILEKMITTGNVSGGEIIDNKFISFTSTTEPQRSKLQELAIVLNEKIQLLTEKNEKTQSNGYGKKQQNKDQQNQQQQNQNQNQQQQQNQQQQQQQQSSQQQSNNILSEESANKFRYANVNSNNDEFQATA
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MIGKVVVSVASVLLLVGVAIGVVVIINKNGNTPLSPQMKAVQGICQGTSDKASCVKTLEPVKSDDPNKLIKAFMLATQDALTKSSNFTGKTEGDLGSSISPNNKAVLEYCKKVFLYALEDLGTILEEMGDDLNQIGSKIDQLKQWLTGVYNYQTDCLDDIQEDDLRKTIGEGIASSKILTGNAIDIFHTVVSAMAKLNVKVDDFKNMTSGVFSPSDKGAAPVNKETPPVVDTPVADPDGPSRRLLEDIDETGLPTWVSGADRKLMANAGRGRRRGGGGARIRANFVVAKDGSGQFNSVQQAVNACPDKNPGRCIIYIKAGIYREQVIIPKKKNNIFLFGDGARKTVITYNRSVGLSSGTTTSLSATVQVESEGFIAKYIGFKNTAGPNGHQAAAIRVNGDRAVLFNCRFDGFQDTLYVNNGRQFYRNCVVSGTVDFIFGKSATVIQNSLIVVRKGNKGQYNTVTADGNEKGLAMKIGIVLQHCRIVPDRKLAAERFTVESYLGRPWKQYSTTVIMNTEIGDLIRPEGWRVWDGENFHKSCRYVEYNNRGPGANTNRRVNWAKIARTAGEVNQFTVANWLSPANWIQQANVPVTFGF
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
Subcellular Localization:
Plastid, chloroplast thylakoid lumen.
Sequence:
MASCVSRFLGLHCGVGFTPPAPRQFRPVAKISVGQRMPPFTLRDQDGTLVNLLDFKYKPLVIFFYPADNTPACTREACAFRDSYQEFKKAGAEVIGISADGQETHKEFRQKHHLPFTLLCDSSDKLRKELEIPGEFFGALPGRETYVLDRKGIVRMVFNDQYAAEQHVEEALKAIRTMTKRGFGG
The following text describes a protein:
Function:
Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds.
Subcellular Localization:
Mitochondrion.
Sequence:
MGPAPRILELFYDVLSPYSWLGFEVLCRYQHLWNIKLQLRPTLIAGIMKDSGNQPPAMVPRKGQYIFKEIPLLKQFFQVPLNIPKDFFGETVKKGSINAMRFLTTVSMEQPEMLEKVSREIWMRVWSRDEDITEYQSILAAAVKAGMSTAQAQHFLEKISTQQVKNKLIENTDAACKYGAFGLPTTVAHVDGKTYMLFGSDRLELLAYLLGEKWMGPVPPTANARL
The following text describes a protein:
Function:
[Capsid polyprotein]: The C-terminus contains the capsid protein. The N-terminal region may act as a prohead protease.
Subcellular Localization:
[Capsid protein]: Virion.
Sequence:
MKTNRAYSTLEVKALDDEKRVITGIASTPSPDRMQDVVEPKGAQFKLPIPFLWQHNHDEPIGHVTEAKVTQKGIEVSVQLTQVEEPGKLKDRLDEAWQSIKSGLVRGLSIGFSAKEFEQIPGSWGLRFLSWEWFELSAVTIPANAEATITSVKSIDREQRAALGIKSVPVVRVTPAGASAIKTKTIKVPKPQEGNDMKTTAEQIAEFEATRVTKAAEMEAIMTKAAEAGETLDAEQSEQFDTLEAEIAAIDKHIGRLKQMQKAQAANAKPVTEEAGAQRMANVKALDFKEVQVRAKNTQKLEPGIAFARAAKCLALGHLEHRDAIGIAKSLYDGQDSIIAATQRLVTKAAVAAATTSDATWAGPLVGDETSVFADFVEYLRPQTILGRFGTNGIPSLRRVPFRVPLIGQTSGGDGYWVGEGQAKPLTKFDFERKTLEPLKVANIAVATMEVIRDSSPSADVIIRDQLAAALRERLDIDFIDPAKAAVAGVSPASILNGVAGIPSSGNTADDVRADIRALFNAFIAANNAPTSGVWLMPATTALALSLMQNPLGQAEFPGISMTGGTLFGLPVIVSEYIPTASAGAVVALVNASDIYLGDEGGVDLSMSTEASLQMDNAPDNPTTASTVLVSLWQRNLVGFRAERAINWARRRASAVAYLTGVNWGAA
The following text describes a protein:
Function:
Voltage-dependent chloride (Cl) channel critical for proton motive force (PMF) partitioning across the thylakoid membrane by anion influx into the lumen during illumination, thus being required for photoprotection under fluctuating light conditions. Influences thylakoid ultrastructure, including lumen size and organization. During photosynthetic response on transition from dark to low light, involved in a sequential mechanism of adaptation; VCCN1 and CLCe first trigger the activation of photoprotection, which is later down-regulated by KEA3 to a low steady state, while adjusting electron transport. On transition from low to high light, accelerates the activation of photoprotection by building up a pH gradient across the thylakoid membrane.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MYQSMNLSVSSNFTHRSLLESRFPIFSTGFRKSVNLKPPRVSSGPESNDSGHETLTDKLIHLLRAVPDWADEIKERGMQQKRSLYTHEKWVEHRSSLRHVRHLLSSFSSRVILSLIPPVFFFTSVAVVIASYNSAVALDWLPGIFPILRSSSLPYQLTAPALALLLVFRTEASYSRYEEGRKAWVGIIAGTNDLARQVICSVDSSGDELIIKDLLLRYIAAFPVALKCHVIYGSDIARDLRNLIEADDLSLILQAKHRPRCVIEFISQSIQLLKLDDAKRDLLESKMLHLHEGIGVCEQLMGIPIPLSYTRLTSRFLVFWHLTLPIILWDECHWIVVPATFISAASLFCIEEVGVLIEEPFPMLALDELCDLVHSNIQEAVKSEKVIRNRIIAKIKLHEFKHSSNGRHRS
The following text describes a protein:
Function:
Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast and occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Miscellaneous:
MISCELLANEOUS: Present with 8530 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MSLPLRHALENVTSVDRILEDLLVRFIINCPNEDLSSVERELFHFEEASWFYTDFIKLMNPTLPSLKIKSFAQLIIKLCPLVWKWDIRVDEALQQFSKYKKSIPVRGAAIFNENLSKILLVQGTESDSWSFPRGKISKDENDIDCCIREVKEEIGFDLTDYIDDNQFIERNIQGKNYKIFLISGVSEVFNFKPQVRNEIDKIEWFDFKKISKTMYKSNIKYYLINSMMRPLSMWLRHQRQIKNEDQLKSYAEEQLKLLLGITKEEQIDPGRELLNMLHTAVQANSNNNAVSNGQVPSSQELQHLKEQSGEHNQQKDQQSSFSSQQQPSIFPSLSEPFANNKNVIPPTMPMANVFMSNPQLFATMNGQPFAPFPFMLPLTNNSNSANPIPTPVPPNFNAPPNPMAFGVPNMHNLSGPAVSQPFSLPPAPLPRDSGYSSSSPGQLLDILNSKKPDSNVQSSKKPKLKILQRGTDLNSIKQNNNDETAHSNSQALLDLLKKPTSSQKIHASKPDTSFLPNDSVSGIQDAEYEDFESSSDEEVETARDERNSLNVDIGVNVMPSEKDSRRSQKEKPRNDASKTNLNASAESNSVEWGPGKSSPSTQSKQNSSVGMQNKYRQEIHIGDSDAYEVFESSSDEEDGKKLEELEQTQDNSKLISQDILKENNFQDGEVPHRDMPTESNKSINETVGLSSTTNTVKKVPKVKILKRGETFASLANDKKAFDSSSNVSSSKDLLQMLRNPISSTVSSNQQSPKSQHLSGDEEIMMMLKRNSVSKPQNSEENASTSSINDANASELLGMLKQKEKDITAPKQPYNVDSYSQKNSAKGLLNILKKNDSTGYPRTEGGPSSEMSTSMKRNDATNNQELDKNSTELLNYLKPKPLNDGYENISNKDSSHELLNILHGNKNSSAFNNNVYATDGYSLASDNNENSSNKLLNMLQNRSSAINEPNFDVRSNGTSGSNELLSILHRK
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLTRYQSRNEYGLADPDLYQSADKDDPEALLEGVAMAGLVGLLRQLGDLAEFAAEMFHDLHEEVMATASRSHGLMARVQQLESELPFVEKALLCQTDHSPFFSNKGVEWHSNLQMEQSVVTRGDLPRCVMDSYEESRGPPRLFLLDKFDISGAGACLKRYTDPSFVRHETSSYEASWDDIQREKKSLKAKRRASHWRNGGTPENALTSHAKLHELFREEHLEAIHSDPARVVKLKTRKLDGYSLISKSGESYMGRFVQTSVNNEAGYENISLNQPELLTWNIDSAKDVVTDIPEISMLDAPEKSHGGTRTDVSLPNQQENAGFIEKDIETVPESTHNGFPGTTLTKDSQTNLNGKQGFLQHRSYSEDLTSEADNYVDAPATMESETETDDEYSRLKHRSDALNDGNHHTYSDVDEKRENPPQFSFLHSVGNTPVSENGQGSFGKRSTCFSYSDTASVSIDDQSDGEKFSGRLPSTSSVKSELVGPSSTATPEANKVSHDSNVQESVSSSNADGQASFISNDSCSSPRSVSQNAESCSLTVQSLAPEVVETSVELARINPVKGGNDGSEVDPVDSRSGASFDVKNSNFPSETSSVSSTSEGSKYDTAVQKNCMVDYSSNVANSVPGPPVFVDSQTGEQLPVADNDVETNSPVAANSGNDTESCDGSSRTGEVLPFSAGMEMEVSPDFASKVCLPGTIDESLFEDTLDDETPSVTVANAVSGVDSRSADVDNEQSCAFGTTAEVSVSESHEDTLENGMPAPTELDSMLTSAFNSGGEKSMGYASPSCSRFDEQISDIPAEFHSSHIHDEGVHDLPGLDNISTDIVPKEDLAVSDNHADISSDDEDHAVSLSSTSMKGSLPWRSTNTSKSSSEATDSCHDTAVESNGILPAKNNSALEKTVQESPLEASSEGLGTSLDNNDLAGSESVSPMISLDQSNRDTETKSSCESIPDENGIDSLPANNLNLLESLTTEPLVKVKTPCVSHALEDEELKQSSVSRGLEFVPQSAGIEWNNPKQELNLDPIFPSFGLIPETTTPNQEDMPPLPPLPPMQWRIGKAPQSFLPNFMGELGETSSSASSAAPPSGSSLNVQLWSTPELSESIGREKSEQLPGESMTSESEKPLHSSIQFPSVATDLNSQYDTDPSIELLAIPNHGSIEDVGSEENNLLADHTSQNQELVYSQESSLQLPQEPSA
The following text describes a protein:
Function:
Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation. Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection. Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells. Inhibits degranulation and induces apoptosis of mast cells. Induces maturation and migration of dendritic cells. Inhibits natural killer (NK) cell function. Can transform NK cell phenotype from peripheral to decidual during pregnancy. Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity); [Isoform 2]: Acts as an eosinophil chemoattractant. It also inhibits angiogenesis. Suppresses IFNG production by natural killer cells (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Secreted. Note=May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation; [Isoform 2]: Secreted; [Isoform 3]: Secreted.
Domain:
Contains two homologous but distinct carbohydrate-binding domains.
Sequence:
MAFSGSQAPYLSPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTRFAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFKVMVNGILFVQYFHRVPFHRVDTISVNGSVQLSYISFQNPRTVPVQPAFSTVPFSQPVCFPPRPRGRRQKPPGVWPANPAPITQTVIHTVQSAPGQMFSTPAIPPMMYPHPAYPMPFITTILGGLYPSKSILLSGTVLPSAQRFHINLCSGNHIAFHLNPRFDENAVVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHLFEYYHRLRNLPTINRLEVGGDIQLTHVQT
The following text describes a protein:
Function:
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
Subcellular Localization:
Secreted.
Sequence:
MKLSVCLLLVTLALCCYQANAEFCPALVSELLDFFFISEPLFKLSLAKFDAPPEAVAAKLGVKRCTDQMSLQKRSLIAEVLVKILKKCSV
The following text describes a protein:
Function:
Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV
The following text describes a protein:
Function:
Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
GGECACAGPSGSRAASAAPPSKEASGDVAAEGTVGRSVGRSVGRSVGGRSVGPLSGEAAPETREVRDGDPPEGLLKRWSRERRPPLPRVSAQEDPDPPPPPPRCIRPPSIPDSGWGRLRALFDRDDTEPVPEELENVCKAAAAGAIVGWAYGGLPAFFQAKQRYIEQSHAEIYHSRLDAVQSAHRVALRGFLRYGWRWSWRTAAFVAIFNSVSTALTVYRDKDALSHSVVAGGESVSRRARASPRASPSPPPALGLSPLEEAAPPARATERAPRRAGGVGGTGPSPDAPPPHPPPADPSLVRLRFRGDGQPVPDAAGPGRPGGRRRVRGPAGVSGAGGEGPGSSAVVVPVETEGPPRAERPGPSLPSSRTPPARLPPPRERPDGPRSRVRPPRPPVTLGAPGRFLANLGTGQRGRHPAVTCPSAVSPTPGGGPRAPVSLGQPSRSPRQRPGRRPADGRAEAVRGDGVGETAEGTAGTVPAQGGRMEVPAAGHPHARRGDGDGPAGEAVGGGHPEDRGAAGAPQEPAPGGGGGRNLAPSRDPVAGPGPCGGGDGTGRRVVAPGPPGAPRQERVQVTPRPGERDGPVEPLGRRGAGSPAGPLPSHRDRNETARPISFMKSLFPVDRRGGGPGGRGAARCVPGRRSGRGGRAPPPGSARPPGGGSEAAGPTRGLGRRGIGTGGGRCPGFSGSADVGAGGKGGGRRGPARRRSSTDIPPPPMDRWDVPPAAGGRPAPPEPTEASFLPPAAGREARGGPRVSGPGPGPESGGGRSDPSVPSARPARGPRSDSFPLLR
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MEYRSSIKRLVVLFCFVCLIAYGNGDNEHEKIKVKTHHDEPEEKHYLKDGQHNPDYDAEMFLGRDRATLFKELPEKEVQERLRSLLHQVDTDHDKIISEREMEQWLRKIDNDRLANDAKVVFEEMDDDKSKSIDFKEISKHTFGDTVDEDIAKSEEFSKYVDRERRKFALADIDNSESLSFDEFVTYQHPERHQHLSDVVVTDVLNEIDKNNDGYVEFSEMIGDSGNSDGKEDDWIKNEKKEFAKYDKDGDQKLSTSELKEWVIPDRKYIDEEVQHLLEGADTDHDGRLTIREALAHQNLLAGSKLTDYGNLNILREEL