lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Flavoprotein monooxygenase required for N-hydroxylation of lysine. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced by the organism under iron-stressed conditions.
Subcellular Localization:
Cytoplasm. Cell membrane.
Sequence:
MKKSVDFIGVGTGPFNLSIAALSHQIEELDCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKRRLFLVQTSQGEYFARNICLGTGKQPYLPPCVKHMTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLEEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWKLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFVVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT
The following text describes a protein:
Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MPRSKRSKTVVLAKVEKKTREAKQEIIKQIREAFDTYDTVYVIDSHNMTSSSWQQLRTSMKGYARIFMGKNQLMRYALGKTEEESYRTKTWQLGRLLKGMTGLLFTSAPEEKVRSALASVARPCLARGGDVATKTIVIPQGPLDRDKYSFALEPELRKLGLPTSLQNTVIHVLCDHVLCKEGDVLTSAQARLLKHFDHVLSESSVTLRGVWHKETEDLDVLDPNCLYLLDTAPAEEDEQSD
The following text describes a protein:
Function:
Extracellular metalloprotease that contributes to pathogenicity.
Subcellular Localization:
Secreted.
Sequence:
MKLQLPTFQYFLVFAATVFSTVNAKYLRFDNHQLWRVMPTTPAHSTIIFDLQESNVIDVWSTKSQGGMILMRVPPTSIDAVKTLLDNSGISHTLVVPSVQDLIDQEKQEFIPMDTTLNEFTADFTRVQHEQQQVLGLPENTVSSDMSDSLLSASFFNKYHTIDELHEYYRALAKTYPDLVETFSIGKTYQGRDILGVHIHAKHSVNRVAEPKEIVFHGGMHAREWIAPAVVTFMATQLVEQYNKNTDVTTMLDTFIYSIIPVLNIDGFVYTHKKDRMWRKTRQPNRFACVGTDPNRNWEYAWGTGGSSSNPCSEAYMGPKPFSEPEPRQMAAYVQSRAPNVISYIDFHAFSQLWMYPFGNICNHPAPDSAKLMRVGKAAVGALKSVHGTSFQVGPICDIIYQASGSSVDHIYARANVTFSYAVELRDTGNYGFILPPKYIIPSGQETFAGIIAMSLQIIKEISNQVL
The following text describes a protein:
Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Sequence:
MWVFGYGSLLWKIDFPYEERVIGYIKGYQRRFWQHSTDHRGIPEKPGRVVTLIKEPESTVWGVAYRIPENRVQEVKKNLDYREKGGYTAEYVLFHPRDQGLQPFSLMIYIGNPGNPDFAGPAQLKDIADVISSSVGPSGRNTEYLFNLAKYVRQHIPEDKDSHLFELENLVKIAQQDHFPHNHI
The following text describes a protein:
Function:
Catalyzes the introduction of a C-3,4 double bond into 1'-hydroxy-gamma-carotene and rhodopin (1-hydroxylycopene) to yield 1'-hydroxytorulene and (3E)-3,4-didehydrorhodopin, respectively. Can also 1-hydroxy-all-trans-1,2-dihydro-neurosporene, 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene and 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene. Probably involved in the synthesis of myxol, a gamma-carotene derivative (Probable). May use FAD as a proton acceptor (By similarity).
Sequence:
MKKAIIIGSGIAGLAAALRLKKKGYQVSVFEKNDYAGGKLHAIELGGYRFDLGPSLFTLPHLIDELHQLFPDVEIDFNYIKKKTACHYFWEDGTSFEAPADLENFAVKAAEIFDEKQNTLSKYLQNSKMKYESTKSLFLEKSLHKSNTYFSKQTLKAILKIPFLGINNTLDQENKKFSNPKLNQLFNRYATYNGSSPYLTPGIMSMIPYLELGLGTYYPQGGMHRISQSLFELAQKVGVEFRFRKNVKKINHSNNKVTGVTTEKGTHDADIVLCNMDVFPTYRQLLQDIKAPEKTLKQERSSSALIFYWGIKKSFPQLDLHNILFSENYKAEFEAIFNNKSLYEDPTVYINITSKQSPQDAPKGCENWFVMINTPGDYGQNWENLVIKAKKNILSKIKRCLNIDVEELIDVEYVLTPQGIEKNTSSYRGALYGAASNNKFAAFLRHPNFNKTIGNLYHVGGSVHPGGGIPLCLLSAKITADLIPNTNA
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
Sequence:
MANRVQIPTSNSALIAMIADEDTVVGFLMAGVGNVDLRRKTNYLIVDSKTTVKQIEDTFKEFTTREDIAVVLISQYVANMIRFLVDSYNKPVPAILEIPSKDHPYDPAHDSVLSRVKYLFSAESVASGRR
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MSPNSGIGSSFVLGVLILCRGRMSRSNFELEVKVESRVEYQGRVSGLNFGSSPGSATGVGYQVLSQGRVLGQVSKLGPDWVLGSSSRMGVGVESRVSSVAETAGCSSPDFVVEVISIFFKDAEKLLNNLAMSLSNSSSFMPNQPGLVSSFGMYCGYLYRQQQVVDFKQVDAHVHQFKGSSSSAGAERVKNVLVTFRNFCEEKCHDSSKGLSRDGYPELYIW
The following text describes a protein:
Function:
Transcription factor that may act as negative regulator of phyB-dependent light signal transduction.
Subcellular Localization:
Nucleus.
Sequence:
MSDGNDFAELLWENGQAVVHGRKKHPQPAFPPFGFFGGTGGGGGGSSSRAQERQPGGIDAFAKVGGGFGALGMAPAVHDFASGFGATTQDNGDDDTVPWIHYPIIDDEDAAAPAALAAADYGSDFFSELQAAAAAAAAAAPPTDLASLPASNHNGATNNRNAPVATTTTREPSKESHGGLSVPTTRAEPQPQPQLAAAKLPRSSGSGGGEGVMNFSLFSRPAVLARATLESAQRTQGTDNKASNVTASNRVESTVVQTASGPRSAPAFADQRAAAWPPQPKEMPFASTAAAPMAPAVNLHHEMGRDRAGRTMPVHKTEARKAPEATVATSSVCSGNGAGSDELWRQQKRKCQAQAECSASQDDDLDDEPGVLRKSGTRSTKRSRTAEVHNLSERRRRDRINEKMRALQELIPNCNKIDKASMLDEAIEYLKTLQLQVQMMSMGTGLCIPPMLLPTAMQHLQIPPMAHFPHLGMGLGYGMGVFDMSNTGALQMPPMPGAHFPCPMIPGASPQGLGIPGTSTMPMFGVPGQTIPSSASSVPPFASLAGLPVRPSGVPQVSGAMANMVQDQQQGIANQQQQCLNKEAIQGANPGDSQMQIIMQGDNENFRIPSSAQTKSSQFSDGTGKGTNARERDGAET
The following text describes a protein:
Function:
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence:
MSEPSAVSVAVGEPTTQWAYRAQKSIGLNTGSPSYTSVSGFDQVTGATRVFQYSPDGSTFAAAMDDFTRLVDTRAASTSSVKRDLPVPKVVDLQFSPRGAFLSTWERPSKLDDGSNARNLKMWDTETGETVAAFERKSQEGCFFQFTANEQYCVRQVSTELQIYEPRHITDKGVIGRLRLEGITSFEVGPGDKPSIAVFCGEKKGAPASVRVYSLASLIPCPESPPAPVSQKTFFKADKIQIKWNKAGSALLFMTSTDHDKTGKSYYGETNLYLMSVRGDFDCRVALDKEGPIHDFEWNPNSKEFIVIYGYMPAKAVLFSHRVNVIAELGTQPRNFVAFNPQGRLFCIAGFGNLSGTVDVWDRQELSKGKIFSMDASNSSVCQWSPDGHFLLTATLSPRLRVENGVKIWHCTGQLVHVDMIDELYQAGWRPGSNAGLVAFPAQIPSAPAASAAAASYLATKAATKRPTGTYRPPGARGQGTPDIYKRIDEGGSGASTPDLARSGSQNGTYQAPGSGNRKRAIPGAPGSAPRTNGNAATNQKDGKKKGGKQQQNGKNANAASASVTVVEESAGTASSGAAEVGGNSSAANLEKKVRNLNKKLKAIEELKLRQAGGEKLEAMQLAKIAAEQEVRRDLATLE
The following text describes a protein:
Function:
Out proteins are required for the translocation of pectate lyases and cellulases across the outer membrane.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKNTPEVKASPQTGYRIPGYLLVVYALLLFTLGWFGHQRWADISPIPLSTSAAAIAAPPTKVGMVPASTAVTADENHPGSLHAAAENSATQTAASGSQTSASSQEATPDTKPAKLVTGWQTAKPGELPYIAFSAHVYTSAPDKRSVTLNGERYREGDSPYQGLVIEQIEQDMVIFSFNGEPFILDSLQDWPGGKPGDDAAQGNEQEPTSKPEQTVRTTKK
The following text describes a protein:
Function:
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs.
Subcellular Localization:
Cytoplasm, P-body. Cytoplasmic granule.
Sequence:
MENDPFLRQYQPSELKIASEFLTNWLPFLSKDLCKDCNHLLSNRIRSLDPAHCSNNTDKVDGECKTGSCSVVENMGSERASNNVDDNYDEKSENGEDCDNHSLGSWKGSEIVFGSFPEDFSSVLQSRPAVVETASPRMRWADMAQEDEFDEEEEEEEEERDSSRKGFDASSMKTPEKPKLSRDQRENLRLINVKRKKDFICLERVKGKIVNVLDGLELHTGVFSAVEQKRIVDQVYQLQEKGRRGELKKRTFTAPHKWMRGKGRETIQFGCCYNYAPDRAGNPPGILQREEVDPLPHLFKVIIRKLIKWHVLPPTCVPDSCIVNIYDEGDCIPPHIDNHDFLRPFCTISFLSECDILFGSNLKVEGPGDFSGSYSIPLPVGSVLVLNGNGADVAKHCVPAVPTKRISITFRKMDESKRPVWFTPEPDLQGIEPLPLDLNRSGSTSRFSRLNNHNGTNQRGHGRRGGGNGYDSRGYYNPERSSEHNDSGDWPSSQRRGMPRPSRRNYG
The following text describes a protein:
Function:
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Domain:
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
Sequence:
MLSFVDTRTLLLLAVTSCLATCQYLQSGSVRKGPTGDRGPRGQRGPAGPRGRDGVDGPMGPPGPPGSPGPPGSPAPPGLTGNFAAQYSDKGVSSGPGPMGLMGPRGPPGAVGAPGPQGFQGPAGEPGEPGQTGPAGPRGPAGSPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGVKGHSGMDGLKGQPGAQGVKGEPGAPGENGTPGQAGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGELGPVGNPGPAGPAGPRGEVGLPGLSGPVGPPGNPGTNGLTGAKGATGLPGVAGAPGLPGPRGIPGPAGAAGATGARGLVGEPGPAGSKGESGNKGEPGSVGAQGPPGPSGEEGKRGSPGEAGSAGPAGPPGLRGSPGSRGLPGADGRAGVMGPPGNRGSTGPAGIRGPNGDAGRPGEPGLMGPRGLPGSPGNVGPSGKEGPVGLPGIDGRPGPIGPAGPRGEAGNIGFPGPKGPSGDPGKPGERGHPGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGTTGEVGKPGERGLPGEFGLPGPAGPRGERGTPGESGAAGPSGPIGSRGPSGAPGPDGNKGEAGAVGAPGSAGASGPGGLPGERGAAGIPGGKGEKGETGLRGDTGNTGRDGARGIPGAVGAPGPAGASGDRGEAGAAGPSGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGEKGTKGPKGENGIVGPTGSVGAAGPSGPNGPPGPVGSRGDGGPPGMTGFPGAAGRTGPPGPSGIAGPPGPPGAAGKEGIRGPRGDQGPVGRTGETGASGPPGFVGEKGPSGEPGTAGAPGTAGPQGLLGAPGILGLPGSRGERGLPGIAGALGEPGPLGISGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGSDGPPGRDGQPGHKGERGYPGSIGPTGAAGAPGPHGSVGPAGKHGNRGEPGPAGSVGPVGAVGPRGPSGPQGIRGDKGEPGDKGHRGLPGLKGYSGLQGLPGLAGLHGDQGAPGPVGPAGPRGPAGPSGPVGKDGRSGQPGPVGPAGVRGSQGSQGPAGPPGPPGPPGPPGVSGGGYDFGFEGDFYRADQPRSQPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWNSDYYWIDPNQGCTMDAIKVYCDFSTGETCIQAQPVNTPAKNSYSRAQANKHVWLGETINGGSQFEYNVEGVSSKEMATQLAFMRLLANRASQNITYHCKNSIAYLDEETGSLNKAVLLQGSNDVELVAEGNSRFTYSVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFRVEVGPVCFK
The following text describes a protein:
Function:
May have a role in hematopoietic cell differentiation.
Subcellular Localization:
Secreted.
Sequence:
MLFMAGPAASWSLRPLGLHGVPQALCAVLLTVLVMKTLVLGDTKLEDLHPQSLPLNKYLNCYRCLLETEELGCLLGSDTCLTPLGSSCVTLHIKNSSGFNVMVSDCYSKEQMVHCSYTRASPVFGFWIFYQCCFLDFCNNPDNRKNSMH
The following text describes a protein:
Function:
Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
Sequence:
MYSEWASLQSSVLSDAGSASVLHTFPEGVGRDVACSVVRHLSHGLSHGGGEDGQKLDSEQQVNWTMEVLCYGLTLPLSDHETIRDCVNVYNDWLTVLTTPKTSVPRPILEEPNKYAQRMFKHLHNLFLPRSEGNTYVDKQVIMCHRILRTSQTIAKESPIMTQQTWEGLLLFLLGVNDTLLAPPTAQGSIADQLCDRLVSVLFEIWLVACARCFPSPPLWKTLREMCITWRHHAAMVDQWNRFNVLLTSKVLKIMYGPDFPELKIAEEDISMVPADMQNECVVQTWFRCLHVLGNPVDLSNPNVISQTPRFIHMAMISDVVIDPSHHPCLKRLPAIFLRAMKGISGLVDAFLGMSSPREIEEIDSAPTTPQVFRGSASTTPPGSRKNVRSFMPSISGKDKAEFRKSAPAILPRQPSASSVTLFSSDQHTVPSPCRPKVNSVLHLFGAWLFDAGLAGCELEPTHKRQGSFSSMGSRRSSAAFPSSSQDVAAAVDSPEYPESYESGRAEACGTLCRIFCSKRSGEEILPAYLSRFYLVLAQGLQVGRYCSREVMAKIVVNCTDLLRSDLKGVDVLLPRIVDALEIILPDRELIKFRRSSSSVSPDLASSGQSAFPFPHEQEPPVCPYVNQIELRRSAIQLLLSILCLPLHFRDLQIQDILRTHETDEQPEHNTFLSLKLRMVNLLIGSLQCEQDSDNTQMILGGMLLCVQDAALLEEAELQAAEQAEREQQNEESENAEKAADQEQKGTVDAPDHETPASKLAQGLYSEYDSAYGLFVRCIHLVCQRLMSAWKTDLNVSLAALELLSGLAKVKIVIQDVLECKRAVKWICDYIGYQCSRPPPNHSRDLHSMIVAAFHCLTVWLVEHDDLMNDKECLQHVLETVELGISGSKSKVKASDQPKYKGDKELKPASMRVKDTAEATLYVVMSQVGSFPPTSGPASLCTLLNEEAIMKYARGSTSEGSLPFRYFVLDKNIIMGILEQPLGNEQDPMPTVTVLIRTPYGRHAWTMQHRQLSWQDRLGSRSALNDPGRPVPMSDVGLHHDVTHRNFPEEVDRVPPTKADLSIPTLQQITGEKLQQELDKLRALMDVQVKYETAINVLTEKRIASTTFPNSDTECKPPKIVQEFHPSRLFLSQLGFLSLDGLKSAPNSPLPALIALDSKATTFHLDLELLDSIPVRSFDTVFVFYVKCGQKMATDILNNVEAAENVQPQFLEFLRSLGWPVEVGRHPGWTGHVSTSWKLATDDDVFDDSTPVADGTGGSLFNGDKQVLYYGDISSEVAFVVPSGSRQGNCRDQLPDKQAVDRTSTQGDAMATGPGPSRNLTLELAGVDPSPGAVGPSPDTPTCHGRKRHLPSRANMHVGPDTKVLVIWVESYDDIEDFPLEDLLSECATGMDYASSTSSLGSRPGMEAFVIFIHPLKTGLFRVNMHGPAGRVSKAIPLVDGMVVSRRALGALVRQTAINICHRRRLDTDTYQPPHIRRKIKIQEVVTKYRSQMSEPEFYTALFHDM
The following text describes a protein:
Function:
Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity).
Sequence:
MGTQPSYSIHTLRAPPKAKQNQIPPSTTRRAVNVNKLGRQFRYPSVGMFTPEMAKRLAALVKMEKDLLRSYENVAMERKECANQLSYWGEDCDDDISDISDKLGVLLYEIGELEEHMVDRYDQYRVSLKTIRDIEASVQPTRVKKEKLLNSIYDVRSRDPESPKLITMEQELVREEAACLVAEAQLTNITRENFKRAFTLHIGTLLEHSEKVAILCGYAKKILDLLDDTPIVPGEPRPIYDGYNITRDYIVEAERELANWQNPFQTPEPLTDIDGLPSQSHYQTQFQASVVPRTDVINEPPRRYSHANGVTTSGTTHSYTSTGSKRYSQMGTEDYQPSFQPNILQSTQVVDNFEIGEEDDEEVGSQGVAETSMPSTSAQPIAA
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
Subcellular Localization:
Endosome. Late endosome membrane; Peripheral membrane protein.
Sequence:
MTEYYDLNLLEKETSEENNFHTKNQQVREDLSILYSILVALEQLEKAFTKDAVSTSDFNSTCELLIQQWESCFSDERVTQAFGSFEDFCSKYRLQCPRAIKRIQEGISDERSQSNSTFSNAISTTAEPSIAMNDTTPQTVNPTKAPSNPSASIAKSIAGLVQNFITTLDAIRLNFIAKDQLHPLLSELIVSMDDLTESLKIQVSCRNKLVQWLIKINNMNITDQLNDVEKRELLYDLEQAYAECYSLL
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP.
Sequence:
MAEADPGLPTQAIWDIPFESLEFNEKIGKGSFGSVFRGCYLGLDVAIKKIEKADDPEYLKYIDREVSMLQSLRHPFIVNFSGICVHSSGLYIVTEFVSGGDVRQLLKKTPPIGWDKRVSIAVDLAKAMVFLHAKKIIHRDLKSKNILLDEFQRIRLCDFGFARMSEQTKKSRHMTMCGTEGWVAPEILLGMSYDTSCDVFSYGVVLAELITGRKPGVDLWVRSPETCFDINPEELKQKSIPGCPSELISVCVECCLYEPLTRPKFDEILSQLKVCQNNLKVATAAAAAAAAAAAAAAAVVSTPTIQTPIIQTPNISFSPNNSNNNNNNNNNISNISPDITTGIQQINLSSSGGSNNSSPSTPPQGSQLVSLAQSRRNTMSLHRKSMELNLVDGQLSTTPPPTSPIQSRPHKPSDSIWKIAAKPKHVGYQTLKRKQGPCYAALTSHITKMIERATSDYYYDTSYIQDFLLAYRCFAPPQQIFELLLSRYIANSPDNFTNDINGWKKVQRVIQLRVIIFFKRWIDYYPQDFLEEAMEDNLNEFDKISAQQNSSTALLLGTTISNNELLIDPKLMTELQKKRSELELLIQINSPSDFINNNNNNNNNPVNNINNINNNNSVNSSSSNNNNNNNNNNSNNNNNNNNNNNNNNNNNNGLNIINIAAANQSKMMLQNGNNRYSVLVTSNGIGNGEEPYPVSIIPPPTTSEYLDVKDIHSTELARQITIINSFYFNRIKAREFIEYIWEKCGEESTTTPYVGTSFVEVVPAENIHKFVRKCNNLARFVSTEILKQTKLQKRVATIERFIEAAEKCLANNDYAAVFSIVEPLVDQSIERLSDTWRNVSQRNLATFEHLKSIVSKENDHKKYRELLPDAKPPCIPNIHLLLDELSFIETSSPRLLPGGIVNFFHYRQLSRKILQSQQLQSHCFRPIPSIQKVLTKPPSELFDDELIKNNSLKCEPPVSL
The following text describes a protein:
Function:
Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT.
Subcellular Localization:
Nucleus.
Sequence:
MDKIVTPDPSHLNSTDSHNVDEPAEDSFLMLDALESEIHFIKSLKPTICLEIGSGSGIVLTGLAKCLGSCCAYYFSIDINPHAAQVLEVIQNKVDVLVFNPPYVPTDENEIDPLSLIAPSWAGGFRGRTVMSCHSASYVSRKLCLLVNDEEDILNVMKSFSWRGSVIIERKAGREFLKVLKFECVKV
The following text describes a protein:
Function:
Participates in transcription elongation, termination and antitermination.
Sequence:
MVIGTDFLMDSARKPEQPEPHWYFVQVASGCEKKVKTNLEQRIQTMEMSERILKVEIPERQAVRIRQEGSRTASAEKIFPGYVLINMVMDDESWQVVKNTPNVINFVGTEERRRYGRGRGHVTPRPLGSAEVNRIFRAAEQEEPVIKVDLEPGHKIEVTAGPFQDFNGEVVEVNPERGTLKALISIFGRDTPVELGFNQVRRLDE
The following text describes a protein:
Function:
Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes mainly to the cilium basal body and in primary cilia.
Domain:
Although it contains a rhodanese domain, does not display phosphatase activity, suggesting that the protein is enzymatically inactive.
Sequence:
MSLRRHIGNPEYLMKRIPQNPRYQHIKSRLDTGNSMTKYTEKLEEIKKNYRYKKDELFKRLKVTTFAQLIIQVASLSDQTLEVTAEEIQRLEDNDSAASDPDAETTARTNGKGNPGEQSPSPEQFINNAGAGDSSRSTLQSVISGVGELDLDKGPVKKAEPHTKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAHGKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLITGSLPASCQQALPPGSARKRSSPKGPPLPAENKWRFTPEDLKKIEYYLEEEQGPADHPSRLNQANSSGRESKVPGARSAQNLPGGGPASHSNPRSLSSGHLQGKPWK
The following text describes a protein:
Function:
Calcium-permeable cation-selective channel conferring a broad-spectrum clubroot resistance by supporting cytosolic Ca(2+) increase in root pericycle cells. Triggers immunity toward fungal pathogens such as Plasmodiophora brassicae (Pb) and induces defenses. Also permeable to sodium ion Na(+) and possibly other cations.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
METVSAVNQTLPISGGEPVKFTTYSAAVHKVLVMINAGILGLLQLVSQQSSVLETHKAAFLCFCVFILFYAVLRVREAMDVRLQPGLVPRLIGHGSHLFGGLAALVLVSVVSTAFSIVLFLLWFIWLSAVVYLETNKPSACPPQLPPV
The following text describes a protein:
Function:
Required for anchoring microtubules to the centrosomes. Required for ciliation.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Sequence:
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTFQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKALTSGEGALDLSDVHSPPKSPEGKTGAHTPPSKIPRYKGQGNKKTSGQQPGAKKASNDASHSDTSISSSEPKSRSGLHLLAHETKIGSLLSNNSLDVNAKAGPGPEEDDLEGDSFFDDPIPKPEAAYGWRSEPSKQAGSLASLSDAPPLKSGLSSLAGAPSLKESESKRGNTVLKDLKLVNDKIGSLGLGTGEEDDYVDDFNSTSHRSEKSELSIGEEIEEDLSVEMDDVNTSDKLDDLTQDLTVSQLSDVADYLEDVA
The following text describes a protein:
Function:
Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C). Plays probably a role in gene silencing.
Subcellular Localization:
Nucleus. Chromosome. Note=Associated with heterochromatin, and particularly at perinucleolar chromocenters.
Domain:
The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.
Sequence:
MSNGTDQAQPPPENPATPVDSKSRKRATPGDDNWLPPDWRTEIRVRTSGTKAGTVDKFYYEPITGRKFRSKNEVLYYLEHGTPKKKSVKTAENGDSHSEHSEGRGSARRQTKSNKKVTEPPPKPLNFDFLNVPEKVTWTGINGSEEAWLPFIGDYKIQESVSQDWDRVFTLVTSQNAGKTMF
The following text describes a protein:
Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MSLFQQWAFIVKEALDKSFLVAKFFCSVHVANTYLCSTALVQGPSMLPTFSLTNELVLLERISTRNGKAGTGDVVILQSPENPRKFVTKRIIGMEGDKITYIVDPKNSDSTETVIVPKGHVWVQGDNIYNSYDSWNFGPVPYGLLQGKVFWRIWPTSAFGSIGRRPETVDPALKVLEQANQS
The following text describes a protein:
Function:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays a critical role in B-cell development in the bursa. Plays an important role in BCR-induced apoptosis.
Subcellular Localization:
Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction.
Sequence:
MDKLNKLAVPAGEKFRKLQKMVHDIKKNESGIINKFKKFQNEQVALICKTGKDTWDRLKKKPPPSLPRRDYASEHADNEEEQWSDDFDSDYENPDGHSDSEMYVVPSEENPDDSYEPPPSEQEKKKIPSSFPISRGEYADNRTSHHQLPPINKPLPSTPSSALPRPKKPSLPSPAAKPKLPLKPRECSDDEDNYIVPVDNDDDNYIEPTESSTPPPAKPPVNRFMKPPAKSALPTPPKPSLASDMQEVYEVPEEEEELSPPPVTRFTKPLPATRAQNAEHSHMHSMTRESPKLDASRNILPLPRNRLHPKTDHEANNNDENHSFSNTQESKFPPGAAPSPLPRALKKTSNAVNPAKPCLPSRDTFTVNEDKPTAADRRRGSSHEFPLPPLPSGTPKSSLQKPLVLPKVPEAPSRALGTSPHSSISSISSTADQDAGVHSKAWYAATCDRKTAEDALYRSNKDGSFLIRKSSGQDSRQPYTLVVFYNRRVYNIPIRFIESTRQYALGREKCGEERFDSVAEIVENHQHTSLVLIDSQNNTKDSTKLKYIVRVS
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MGGGKYETQMCVIMVEDIFGKIVAKVLETVLKESCHLPTLLLKLKGQMSSVLNRNFKVRKALSTLINFGFVSFSLDTNNRTTYVADADQIQYVISAPRACLIAKTLHGPAAESICVELISQGRLTVSETIRRIRSTDESVEFSDIKHSFEELARAQFLIRVPAVESNLYGCPQLTVNFNQFEMPKNIMEKKEPQTRGSSFNDASSRKRKADASPEDMDAGQYWRINWARFNGYLRDELIIDYLIGGGSTATMTHLNVRKNSEEDVPQQDRTQYITQNVAHLMFKSNELRANPLSMDSITVSITDLQKLVRENELDLSKPDIELACQILVDESDGIVRKVGDSNGGLYTVDIRHGIRQICRHHCESLIREQFEGRAIRVMRLLESRHYLDEEQVEKLSMMSGKEAREMLYALVEEGYVFNKPVGRSNDFQPARTFYLYYVDLPRTIRGLVEYTCKLVRNLILRQRHERTENKALLDKDANVQPIIENIRASDQLDEASKLAQIAEVEEMYLPGPDRAQLNRFRKAQATLLAAQDQSIRVLLAFKLFLASGQS
The following text describes a protein:
Function:
Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention. Binds transporters associated with antigen processing (TAP) and acts as a tapasin inhibitor, preventing class I/TAP association. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Subcellular Localization:
Host endoplasmic reticulum membrane; Single-pass type I membrane protein.
Domain:
The lumenal domain binds directly to the peptide-binding domain of class I molecules; The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Sequence:
MIRYIILGLLTLASAHGTTQKVDFKEPACNVTFAAEANECTTLIKCTTEHEKLLIRHKNKIGKYAVYAIWQPGDTTEYNVTVFQGKSHKTFMYTFPFYEMCDITMYMSKQYKLWPPQNCVENTGTFCCTAMLITVLALVCTLLYIKYKSRRSFIEEKKMP
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKLVEGVQVLLDRGDIPWKKVIAGLNIAQFGFETYLATREYKKLNELSLPSELEGVIDKETMQKTQAYERAKLRYRMVRDLVFLGLNLVMIKYDWLPRMWNLGVAVGQRMPAMLVPVSTISQSLYFLIVYLQLNWWQGLFGSYYYNFVLEEKFGFNKSTVKLWLTDQLKVFMISSMITTPAAYALLKVIEKFSTGFVSYVSILMLFFYLVLTALQPVFTALFNKLTPLEDGELKTSIVEISKRVNFPLDKIYLSDGSRRSAHSNAYFTGLPFFSKRIVLFDTLVNDSTVEEVVAVMGHEIGHWKLNHISYRLLLLWATSGFTVSLFSAIYMNTSLYEAYGFFIGNNASSDPARVVVSTVPVMIGFMLFNDLFQPAGAALQFITNWYTQYQELQADQFAKELGYQDALGSSLIMLARGNLHTPEGDPLYTAYHDSHPSTIRRLRALQYKPAKKQ
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MTRYKATISYDGYAFAGFQRQSHARSVQEEIEKTLTRLNKGQTITVHGAGRTDSGVHALGQVIHFDLPYQMDEEKLRFALDTQSPEDIDVISIELVADDFHCRYAKHSKTYEFIVDRGRPKNPMRRHYATHFPYPLDVERMQIAIKKLEGTHDFTGFTASGTSVEDKVRTITEASLIVDETGQFLTFTFSGNGFLYKQIRNMVGTLLKIGNNRMPVEQIDLILEKKDRQLAGPTAAPNGLYLKEIRYEE