lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. Required for proper pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body.
Sequence:
MLLKVSSCEPLVPIKQWIHTSQLDLSDSSSLVADLLYNIIKFNFSGLEDKRAIFTGYESIKRYTIGNEMFLQLAKDGFALPVSMSYGLFLEETDTLELRALPRSEGLHRGCEVLVLRLDSPNELKENIREWSSKFMNSKASQKQQMLSPETMQKVDLAGRASPRYQANDSWISKKRNAPLSSISQYANMPENYALNTKKSKISNENDTIFKANFQQNKYESLHAKQISASDLSLHQEFVSASIVQQPELNSLLTSQSKNSTPSESDSSSSESSSSVSDSSDLSSTSDSSSGDESSDTARQSSSDTISSNNVSVSVSLNTANEFSFPQGTFKAENEAVESEVAPSSSTPPTVEEISYLHYDEPSQYYFSSPSKLSSETTKVHRGCENTEKPSEEGKNFTTPLSDSVESENTWSNTLRSSVEDDNTGVSDDNKKSKLNAEFDGHVNNISVRPPGSGSSATKARNLRRKKARILKRLMQESNDTFSANESTVVANVPDSYLTKNDEEDSASLASLKVAPKYVSHPVSLSSNSFHTEFPIGSLMRFTVMDLNPVTCTPEISEKTGRVVDCSEEKVKIQLDLGDRLDLKFDVNGEVIRNRYGTTPDEELIEGIATYEWSSLSNVHKLELTN
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MMPSHATMSSPPAGTKLDLSKKLSELRASRRSHSGPSPREPTPVTPPLPSPPDLSTHTYTRPVRRILSRKDHETFLASSTYTLVVSFTFSLSDSVRGRAVTDNKDQPASPNISRILSVIDTIRQLVDKHPSIDQGGSRFGNPAFRDLFDDVAAQNATWHREIIGLQNADAIEEVSSYLVHSLGSRDRLDYGSGHELNFMMWLLCLRQMQMISTADFPMIVFRVYLEYMRLMRQVQMTYYLEPAGSHGVWGLDDYHFLPFLFGAAQLVDHPYITPLAIHNTAVLDEEGDKYIYLDQVRWVDSVKTVKGLRWHSPMLDDISGAKNWLKIEGGMKKMFIKEVLGKLPIMQHFLFGSLLPADPSMGERSDDAQEDDLHDHGNGNPHARHTDHFGDCCGIKVPSTVAAGAEMRKRIGGTGLRPIPFD
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MVLSNIFRLTGYERLHWVLLTPEAGGPAGGTEAANLVLEAFLKLLNLGHLTTWRVIPSDDTKTGGGVQTSPLELWHFETVSSAPSDDPNKELLMLLPGFQVTATGTWSPQSRQPSVSDALSQAIANKLERAFKDLSYHKFGDVFIRTGRQDPSVESPLLACEVRLLSSPDSLYLQANVSRRNVRRLKLSDLSASRPLKVICSPSGEPAFLLGSCSPELVARLTQPDLTQPLDFEPRSEDLDSREKHRAAKKSEKRRGKHEGRAEGIGQHVEVQFDGSSHAGIKAGVTRRPSETLRNPLELDKVEVEQRPAGILEDESEENREADTQTGRDSDHPPAGGPATAEESDRGFQVLNKASVAQSLSALDCPKQSPDQLNPAGRTSAGRNSAGPDRLILPVERVLVSLPNLRQCAAELRIGMGLETVSGVGVTNGFENPQVASLAGWPSEQEASDDDSGSESGSLVDTDAEDEPAEGQLPEPGVKAEVAGHKRDRSEGLRKDDGPPSKVQKTEGGAQSLELLGSGAGEGGAGTGAGWWQDDGMEVGLLADFADFGDAFADVGGFGELPGTSPKGSPEAATEAPILEDVISPSASAAEPLPGARDGTASHFSAGASEVDPSEPLKVLLDDLFLEPTTNERPLSKGLQEGSPSPTYSLAQTKPSGGVAEEDDGLLLVPPEYRAAQLSLPARSDSSHEDATRVRYRPEETKVDFIRAVLGQGKGTAYEALPAGTSGLDEGPAEEVQLRGKYPKPRVRKTRKGELVVAERSGEHLEGSGKPNDGNGSEPRDAQEEVGRAGERKAGKRNSEGKGRPFEQKEEGLSGQRFSARLRSVVATDLVLLQREAARLTRRNGLLAAASNDGIGSETGFLQPSADALAGIHSEWAGSASAPNQQQPGLLLRGSVEGSSDKGFQKATPDWGAGVERKRRLLSPLLLQQAVSGCHNIEAGFRTGPWDEPELAAVGPVSAVAVAEVLASDVSEAFRAAFGEDKFCGPLTVDELCQEKSFGGVLKPPLAMQIGSPAIEHPVTPPQLWAVTLKPSGGVGSAGKSVPPLENPDVTDAETVETDVGIFKLLSAPPFLVGYQEDWLRIPQGVLKQWEKAPLEPYAAPKSVVYYAFCPATSELVSLCGRYLKEVGSTYEMCQLGSHVAASLPPDLATASAPGIASVAIASDPTVGNEATLKSGGERVEAFVEGIRTAATRLRLVGGNGREGREGSEDPCVVVYVVLPLCTDDQAKTATATIASILSGDRTGHRTSGTSGISLGVTQTSLADTRLTLQVISERDVTRAGFQTGAQEAFKRVAFDVYTKARGTNRKLPRGINIDGSSKGKAQEEGAGSGDPGGDGPLLFEPLVVLAEHPPICPVGPTGRSEERETGELEAGEHDLGAGSSVHCCYVWANDGATLVSVWTDGQGELLDAYVQTLAGDNALRSRRTDVAEIGGSLSAGMAELLQPGLAEGDGPELSQSGGVQRRAGPLENDLNLEPPQKDTHLEVEGACSHQALEALLGGLLDQCEYLLALVEAAIPEGEISPPCHVIMSRLGGIPHEESLVWARLLGGRQHDVSKMLRPVLHAGRSPPSGADMAHDERFASGGVPGHGRNLSLEMGGDALPPDMERFPFLEQQCLSPVSPGAFGGRFGGGDERGFQSPPETGRREPRGSLASVTLVVLERERSLQLVHGGDERQGSGSNPIAGMSARAVPPNRNDQLFIPSKPLQRLTRGLSQDGQVEPPLTPVASGYLLGDVRDETRAVCDVMSGVGSFVAGDDWPAAVRVDLISHFAVCVDNVNTLTPVENGQQGAKLLESIIEGFHALSWLNATDTGGCRSSVLPMHAAMVERIVDSVID
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGVEYPSPEDVMEEQEANKPLLVGPSFQQFETNPKESRISVNPEASGSGGFGFKYEPRPYRDKFFSYLFVATVLVTYIFGFLAIKNAESESAIEAKVQFARYDPDSGQCKPIQHAYVGSTPIHVSPSHGRRAYEKDADPVNAAAILVPVIGTLALILPVSLGVFWLLRYHTRQLVTAILCLLCIIPISVAVLASTVCLLSKDVCSQAPVSWIITSVVLGFLALLMLLQFFGMLKRRSRVDLAIQIIQTATEALKHNLYLLLVGPILSLVVVLISGPMAVFIWYAIFIGKVSPNFDAIRDPANMCDQATGAPCCEYQPAGFVFAYIMLVGIAVTWVVMVASQVKVLVVTGTIAQWYFAPAGSSTVGSTKRSLRNALGPSFGTACLSSLIITIMAMLRSLTNTEAGKLGSSILACFIRACFSWLFQIVESFTLFTNNFAAISGDSFCTSARATLNLLRRNFLSTVMVEIMAQTVLSGIVLTTAFINFGVVLGSMYYFTSAGPTYSLLIANACFIIWLLGLGLTIHVLSHVVNTVYICYAMDKDVGAVTKPEVHDVYMLLPPASPGDNAMLAVQQQPHSEP
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MLGAFNSTLARFGGLVHKVPWRLSQRRKYRHRQRLRAVDEVVDVLRTALQEKNQSCKRIESFVANHQPESQMSPKDKYTMFTRKTQGAGLQGFRKGVHKSPKWTRSTNRVNPTGF
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Sequence:
MSRSPQQKTIMWEQDSSLNSASLSSKPQDIVQQKNGLSDNTPQENASPKRTTFPPITIVQRKKVVTNSPLLSSSPRLRDIVPVENNSSTRKKSVPIVIVQRKEIPSNSSVSSPRQKETSPRKDSFSKSAAASSPRAIAQRKNVVSNSPSASPRQREIVERKNSLSNSPFSTPRQKTIAQQKNALSDSPLASPRQSNRTASSPRAIVQQKEVLSNSPASSPRQKAIVQQKNLSDSPLASPRQSNKTASSPRAIVQRKELLSNSPASPPRQQEIVQQKNASSYRTGSSPRAVVQQKVLTDSPASSPRQREIAQRKNVLSDSPASSPRQGGYFPELREGYKEAAGIIKNLEDMADSQELSRKDSGFSSVSSAELLRDEEEAALKAKELEKTEENLKELGKLAKLFDKQGLEFTDAQPKKVEAPSEEEVPLLVQLKMQREKEKVMRMEDGAMPITLETALALRKLLFGTGNYTFNIEWKRTRFTFKEVKSNFPYGLFMEKHGSRGMTMCVQAYILKHLLYRDGCLLEEKGNSNNLLVERFNMGFFEDQRADALLHALADILWKAGEGKYAAVTIVGEKMCLTPNPELRFDGYTEKILIYEFTDFEALLKFLRRNLDQFQGDFSPGGILMVYSAMLSRTFPKLIQDMDEHKTPTMLTPAEGCTTALVNLFLTGRAVSYLFNGKVVYDKKRKPLAYPLIGQKERAELGFLFWDKTEFEVQDKTEVGSMLKTPKLPIWLTSVNDVYGILFCTVPDLLSHWRKEHRFSLFYFTGQASQIQGTKLTIDNRSGRNDAEGDDEEQKIPSLERCILTKWPDAVVNWNGTSPFV
The following text describes a protein:
Function:
Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MEHSELIQEMPHIEQMPTQERLILARKRRNQQLKLWLQKEKEFNRKTPKQQKSNKRSIFFNDSVVLLEAAARNDIDEVRRLLMKGVSPDSCNEDGLTALHQCCIDNNEAMLLLLLEYNANVNAEDSEKWTPLHAAATCGHLKLVRILISRGANLLAVNADGNMPYDICEDEAALDYIEGEMAKRGVTQQLIDDTRAATEKQMLADCRKIASSGGDLEAYDSQGATPLHIAAANGYLTVVEFLLDHNVRTDVRDKDDWQPSHAAACWGHVEVLEMLAQAGADLNAKNKHDETPADICEDPEIKERILELRTEQEIKRQAEAKRKVRRSQSNTRTQSVRRTSLRDKGLTARRDAVEEARLRLQAENKGLDTSEPSPPIQPPVNNNKSPPYSTNNNPEPVKEDSTALQIIENRKAPEGKDNDSMLENHVMDTKENSYTTDVNGKVTVHVVVTINGNGTLADLKKQRMQIRNNSSDVNSITSPMGSITDETSPSPVTADIVRFTGETAEENVGYAKSKRCCVVQ
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWRLLAMMTLYFGSGFAAPFFIVRHQLLKK
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of UMP to UDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MALVIKLSGRVFEDEELVFKYAGVIRNLSGKVAVVTGGGEVARRYIAIAKRGGASNTFQDLLGIYASRLNALLLISLLKDAYPRVPANIEEFLEAWSGHRIVVTGGFQPGQSTATVAALVAEAVGASALLNAANIDAVYSDDPRRNPNAQRLRELKYDEFEKIIRSSSLPGGYELMDVWSISILKRNCITTYVFDGRRPDHVVAAARGENPGSKITC
The following text describes a protein:
Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Subcellular Localization:
Nucleus.
Sequence:
MASQQQPKRKSVGKKAGSNVRRKLKMGEQPKQQVCMVEGQQQQQKKKQKQEPCLNDTLDIDDLLTMMESSVQNQPPPVESAHSSTLPSTVSNVGMYGVEPIAVPVTGVGSFGRNPNPQPSSSSSSGGGGGSHAVNSIGTSRNPPLSYDTPWLTSVVNHGGTNSVSAPEPIAIPSTVSSVGAFGVEPIPQPKTVNGGFYTAQSPNCEEVRLPIHDNVFISCTVFNSRPLISVRQFYTTKDDPTTLKPGKRGLSMTPDQWNKLKESPIYGAIIDCTFPSLPQAATQKPRMFPLGSLRYAVVENANGKPSVGLYQYSSGGGGGGYNNNNSTNLYRTEKGITLSLQQWEALEARKSTVDWIMGAVANGKSPLAWEVIEGIPV
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MTIHTVPQLAAVDSLGNKESNANWGNEAHLKLSQVCPEDSLPPAGQRDNLCQTTVLANPIPQATASQGTEMVDSSVSDKPALGNVNQTKSVTGGEQHLLNLSLTGQCAGETGGNQGDSNANTKMLSPATEKDVCKAGLSAVVTSASKVDMQNNGFQRKEPSKAKEEKWTSSAEATVQMTSEKNVSANEKNELNNAAVAPQQEFKSILVPDSATPQKTEEPVHFQSDSFAKPTPLHGSESLTPHTSTNPLCTSENKDSTSTSNTSCSAHSQAPPTKTAGNTATKSDPTKKKALLKAAQSKKEKTEPEGNTDEEDQSEKEKGKGVHDVVWDEQGMTWEVYGASVDPESLGFAIQSHLQCKIKEQERKLIVQTSIRKSISGVDSPRHDKKNKRRQQNIFRSMLQNVRRPNCCVRPPPSSVLE
The following text describes a protein:
Function:
[Isoform 1]: Catalyzes N-methylation of phosphomonomethylethanolamine and phosphodimethylethanolamine, the two methylation steps required to convert phosphomonoethanolamine to phosphocholine. Unlike NMT1, NMT2 cannot utilize phosphoethanolamine as substrate in vitro. In association with NMT1, involved in the production of phosphatidylcholine in roots, essential for root development. In association with NMT1 produce phosphocholine mainly for leaf growth maintenance; [Isoform 2]: Catalyzes the N-methylation of phosphoethanolamine to phosphomonomethylethanolamine in vitro.
Subcellular Localization:
Cytoplasm.
Sequence:
MATPYKEERDIQKSYWMEHSSDLTVEAMMLDSKASDLDKEERPEVLSLIPPYEGKSVLELGAGIGRFTGELAQKAGEVIALDFIESAIQKNESVNGHYKNIKFMCADVTSPDLKIKDGSIDLIFSNWLLMYLSDKEVELMAERMIGWVKPGGYIFFRESCFHQSGDSKRKSNPTHYREPRFYTKVFQECQTRDASGNSFELSMVGCKCIGAYVKNKKNQNQICWIWQKVSVENDKDFQRFLDNVQYKSSGILRYERVFGEGYVSTGGFETTKEFVAKMDLKPGQKVLDVGCGIGGGDFYMAENFDVHVVGIDLSVNMISFALERAIGLKCSVEFEVADCTTKTYPDNSFDVIYSRDTILHIQDKPALFRTFFKWLKPGGKVLITDYCRSAETPSPEFAEYIKQRGYDLHDVQAYGQMLKDAGFDDVIAEDRTDQFVQVLRRELEKVEKEKEEFISDFSEEDYNDIVGGWSAKLERTASGEQKWGLFIADKK
The following text describes a protein:
Function:
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
Sequence:
MESSQAYFPPSANKKHVLLTWAQSINGRIGYVVESPSLGQLRLSSKESFVMTHLLRTKFDGIMVGSRTAENDNPSLTAKLPDPANPDCLLPLNKQPIPIIVDSNLRLDYASLKVIRLARERLGKPPLIIVAPSIWQQVQHDSKLKEAVKLIQSVGGRCIIRNEDSPDSWSDYVALDKLLQNGVNRIMVEGGAELLAKAFGSTDIDAYVVTIVPKIFSCSNTTEIKNLNNLNLTTNSHWYPCGPDVIFTNYSDEFYESYKSLLTNSDAI
The following text describes a protein:
Function:
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MTTPKPLRIAFIHPDLGIGGAERLVVDAAIGLSRLGHSVKIYTSSHQPERAFIETTDGTIDVKLLGNNLFPRSIKNRFITICAILRQLHLTFNLIVSRLFSDEDSADLYFVDQLSASIPLLRYATRTRVLFYCHFPDLLLSPSNINSNSFGTKGWILSKLKSTYRIPLDWLEEYTTANADTILVNSHFTAEVFGRTMTSIKKKPQVVYPGVDVNIYDCPKPDQPDQKPSVIHSDRPTILSINRFEEKKNINLLLQAYIQLRKSDSAPGASSLVPRLVLAGGYDERLMDNRRTLKALQESVPKDLVQLTLSTEDVGGAERMPDVLFLLNVSQEHKLALLHGRSTKLLGYTASNEHLGIGPLEAMACRLPVLAVDSGGPKETVSDTRTGFLVPPDPEKWAQSIRNILAMDDQQRRQMGDAGRDRVLELFSTEVMAKHFERAIQDILGPVRQTDLWLEQGFFHLLAFILVPFLTIWVGTWKFI
The following text describes a protein:
Function:
Probable RNA methyltransferase.
Sequence:
MDIRNNDPGAVQYGNFFNYYQFSSAAERVKLLPDADIWLPALEDGETQKDKPYFILDVGCNCGVLTQLMHKYLEERLHRSVKVLGVDIDPRLIQRASEENESPKDVSYACVDVLDDEAFESVKTYMEVNNLEKFDAICCYSITMWIHLNHHDQGLRFFLQKLSNLAELLVVEPQPWKCYQKAERRLKKAGEIFPLFLELKWRSDVDLQIQKYLEESLDRRKIFKSAPTKWQRKICFYR
The following text describes a protein:
Function:
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.
Subcellular Localization:
Cytoplasm, cytosol. Early endosome membrane.
Sequence:
MNSLRKWLYKPKKHDTSLLAQFYYADEELNAVATELDSFDGRKDPERCASLVYQLRQCQDKVLTICSQLMDEVMPIDRACRDFRSKFPDDVLQENLAGQLWFGAECLAAGSSILNRETESAVMRPLAKALAKSLETVREQLREQCLRNSMEFPDKLRESLCLFDRLFAEFELSYVSAMVPVKTALEYNHQQDIIVLFSETLQRALSLGLLSQDLVDACDPALMFTIPRLAIVCGLLVLPDGPLNLQRQLSELFRPFRNLLCKIRDLLWTLTSQELQLLEKALCSTDPTPTSDSSGTYPMCKTDEYITKFHQDYPTTQSQHCRSSFRVAGKLSQKNNSSSNAAPAEVANADQGRTGHTVERRTNDEGDTSSCSSTTSSACGTNSDSSSVTSAASECQDDEEIALALQAAEIASRNQIRGRFKSSEDLIHRLFVCISGVADQLQTNFASDLRAILKAVFLINASPFQQETSEEERRSSLPSNVPFRLSQSTPSPDGSPVDDDDSGLLQPDHAETDSLDQTPPSSLSQTSDGTPPLTMHRATTVAPYSGSPSSTFPLDGQLSTPPAWIPDESAPHCMSCQSVFTVVRRRHHCRNCGKVFCGKCSANAVPLPRYGHVKPVRVCNRCFMFHVTHFAVTEASLS
The following text describes a protein:
Function:
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MTASQPLDQADQDSESSSAGSSAAETEHVSVMPNEIVQWVREINPTTIIDGTYGGGGHTRLLAEVLADAGSDSDTPRVIAIDRDPAVVRRDEQKSWIKDDPRIELFLGSYESSPKALDALDLTHADALVLDLGLSSDQLADRNRGFTFTIDDAELDLRFDPENGVPAHRWLQQHSEKEIADAIYRFGEERFSRRIAKQIFLRARERNPVTKVGELVEICRRCVPRSRNHDIHPATRTFQALRIAVNDELGGLTRTLQSAPDWIAPGGRVAVISFHSLEDRIVKNAFREDHRWEILTKKPLRPTDEEVQANPRSRSAKLRVAKRVE
The following text describes a protein:
Function:
Probable methyl-accepting taxis protein. May be the receptor that senses the torque generated from the interaction between the magnetosome dipole moment and the external magnetic field (Probable). Overproduction interferes with magnetotaxis, cells respond more slowly to changes in the magnetic field; requires the MamK-interacting C-terminus of the protein. The effect of magnetic sensing is to control flagellar rotation; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through variation of methylation levels. Attractants increase the level of methylation while repellents decrease the level of methylation.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 20 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: There are over 60 methyl-accepting chemotaxis proteins in this bacterium.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Note=Found predominantly at cell poles or at septa where divison occurs.
Domain:
Only the C-terminus (residues 321-436) is necessary to interact with MamK; its addition to MCP25 confers the ability to interact with MamK.
Sequence:
METTLGSYARTLSLGMLVPSAICLLAGTFGLLGGSSIALWVVIAVSLLGVVGGVKIGGSARRMAGDLSTAIHVLSRSASGDLNARILDVRGSGGIGALQHSINRLLDLAEAFGKEAFAAVESANHGRYYRRIITTGLRGDFVLYAKTINQALKRMEARDAEFIAFANNQVKPVVNAVAAAATELEASSGAMSAQSTDTSHQAMTVAAAAEQASVNVQAVASAVEEFSASIKEISTQVHRAAAVASEAAGVASRTDTTVHGLSDAAQRIGAIVSLINDIAAQTNLLALNATIEAARAGDAGKGFAVVANEVKNLANQTARATEDITSQVAHIQEVAAEAIKAIQEITRTVSQIEETSSAVAGAVEEQNAVTVEIARNVAEAATGTSSVSSAIITVQATAAEATESAGQVADAASELSRQSENLSREVDGFIARIGGR
The following text describes a protein:
Function:
Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase and promotes the transcriptional activation activity ZNF541. Required for the organization of chromosomes during metaphase I.
Subcellular Localization:
Nucleus.
Sequence:
MEEPGGLHESAEDLFHFNVGGWHFSVPRSKLAQFPDSLLWKEASALTSSENQRLFIDRDGSTFRHVHYYLYTSKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGRHHLRVRPADIPVAERASLNYWRTWKCISKPSDFPIKSPAFTGLHDKAPLGLMDTPLLDTEEEVHYCFLPLDLVAKYPSLVTEDNLLWLAETVALIECECSEFRFIVNFLRSHKILLPDNFSNIDVLEAEVEILEIPELTEAVRLYRMNMGGCSRTSCPPLSPGKGGRTASVESVKPLYLMALGLLVKYPDSALGQLRIESTLDGSRLYITGNGALFQHVRNWLGTCRLPLTETISEVYELCAFLDKRDITYEPMKVALKTHLEPRTLLPVDVLSEEWTAEVTIYSPQQIIKLYVGSHWYATTLQTLMKYPELLSNTQRVYWIAYGQTLLIHGDGQMFRHILNFLRLGKLFLPSEFKEWPLFCQEVEEYHIPALSEALAQCEAYKSWTQEKESENEEAFPIRKLHVVTEGTGPMAEFSRDAKETTACMPVDFQECSDRTPWNKAKGNLTRSSQMEEAEQYTRTIQVSLCRNAKRGGNPSTYSHCSGLCANPRHWGGHSESPPKKKCTTINLTQKPDAKDPPVTPMQKLISLVREWDMVNCKQWEFQPLPASRSSSVEEASLHVPSGSEAAPQPGTSAAWKAHSITSEKDAGPQTGPGAGVKDKGPEPTFKPYFPTKRAITLKDWGKQRPKDRESPAPEQPLPNANGTDNPGAILKVAHPPVVGNDGSCMFFEDSIIYTTQMDNIKHTSLTASPQLREVTFLSFSLSWEEMFYAQKCHRFLTDIILDSIRQKDPKAITAKVVSLAYRLWTLNISPKQFVVDLLAIAGFKDDRHTQERLYSWVELTLPFARKYGRCVDLLIQRGLSRSVSYSVLGKYLHEG
The following text describes a protein:
Function:
Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSSESTTFIVDVSPSMMKNNNVSKSMAYLEYTLLNKSKKSRKTDWISCYLANCPVSENSQEIPNVFQIQSFLAPVTTTATIGFIKRLKQYCDQHSHDSSNEGLQSMIQCLLVVSLDIKQQFQARKILKQIVVFTDNLDDLDITDEEIDLLTEELSTRIILIDCGKDTQEERKKSNWLKLVEAIPNSRIYNMNELLVEITSPATSVVKPVRVFSGELRLGADILSTQTSNPSGSMQDENCLCIKVEAFPATKAVSGLNRKTAVEVEDSQKKERYVGVKSIIEYEIHNEGNKKNVSEDDQSGSSYIPVTISKDSVTKAYRYGADYVVLPSVLVDQTVYESFPGLDLRGFLNREALPRYFLTSESSFITADTRLGCQSDLMAFSALVDVMLENRKIAVARYVSKKDSEVNMCALCPVLIEHSNINSEKKFVKSLTLCRLPFAEDERVTDFPKLLDRTTTSGVPLKKETDGHQIDELMEQFVDSMDTDELPEIPLGNYYQPIGEVTTDTTLPLPSLNKDQEENKKDPLRIPTVFVYRQQQVLLEWIHQLMINDSREFEIPELPDSLKNKISPYTHKKFDSTKLVEVLGIKKVDKLKLDSELKTELEREKIPDLETLLKRGEQHSRGSPNNSNN
The following text describes a protein:
Function:
Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import; Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus envelope.
Sequence:
MEEQVQMVGRAFVEHYYHLFDSDRSSLSSLYHQSSMLTFEGQKLQGVDDICSKINQLPFDKCHHLISTIDSQPSSFAGGIVVFVSGSLRLSCEEHPLRFSQMFHLIPTPQGSFYVQNDIFASITVKITFVLFFN
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MGNFFSKKNDTFEKQLLDMESKILNMETKINSSKAFHKDIIRKIVIYSFIVEFFIVLFSYVKSRSSNTFSEKSMCYLYSLLFPILILTLTKSYGFVFQYSIKNYENKLEKLKVGLEKKLDDRKRETDFENTKKLLDKYENIIKKKKNNNNNSNNSNSNTILPTLNGKSNILANNTNRNSRAQQQNPQQQYQRAQYSPPSHPQQQQPQQQPQLQLQQQQQQQMLNPRAQQLQPHYTQQPHHRVQSTSQIRATPQNPKDKWWFDKLIDFLVSDGPTHGSPLICENCGTNNGYVPREEIPSIQFRCIACKFFNSKSENNGHNNGLTKNNNIDGNNNNNNNNNNNNNNNNNIDNNIDNNIIDNNNIDNNNNNNTINSTDNSIDKIDNNIDDKKNKNTNRNINFDSESKEKNSLERDNADKSNNSLNNSLDTSLNNEDSFDMNDTSMESTSSSSKGKKNFIQINFDGSLKGRNKNIRPDYVVDNETGERYKFISYNGDEKINVRKEDNSKYSPSTKDKKRFSYFVVNRGDSSDESDASDYENDDQETNAELQADLDIMISEFKEKLMMPLDKKLKEKDIEIAKLSKELEKYVKKENQIKEVIYKQKEKDQKKDKYR
The following text describes a protein:
Function:
T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.
Subcellular Localization:
Nucleus.
Sequence:
MYHPRELYPSLGTGYRLGHPQPGADSTFPPALTEGYRYPDLDTSKLDCFLSGIEAAPHTLAAAAPLPLLPSALGPETAPPPPEALHSLPGVSLSLENQELWKEFSAVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVVPVDGARYRWQGQHWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRATQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPVATEACGSGDTPGGPCDSTLGGDIRDSDPEQAPTPQEAASASAPPCGGPSAEAYLLHPAAFHGAPSHLPARTPSFAEAPDPGRPAPYSAAFLDLQPGPGGSAYQAAPSVPSFAPHFIQGGPFPLPYPGPGGYLDMGSKPMY
The following text describes a protein:
Function:
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Sequence:
MDILRKVAEIHGTPTYVYFEETLRKRSRLVKEVFEGVNLLPTFAVKANNNPVLLKILREEGFGMDVVTKGELLAAKLAGVPSHTVVWNGNGKSRDQMEHFLREDVRIVNVDSFEEMEIWRELNPEGVEYFIRVNPEVDAKTHPHISTGLKKHKFGIPLEDLDSFMERFRSMNIRGLHVHIGSQITRVEPFVEAFSKVVRASERYGFEEINIGGGWGINYSGEELDLSSYREKVVPDLKRFKRVIVEIGRYIVAPSGYLLLRVVLVKRRHNKAFVVVDGGMNVLIRPALYSAYHRIFVLGKQGKEMRADVVGPLCESGDVIAYDRELPEVEPGDIIAVENAGAYGYTMSNNYNSTTRPAEVLVRENGRISLIRRRETEMDIFKDVVM
The following text describes a protein:
Function:
RNA chaperone required for proper U12 intron splicing and for normal growth and development of plants. Mainly responsible for meristem activity. Plays a role in regulating cell division.
Subcellular Localization:
Nucleus.
Sequence:
MKKRKIHHSDDEEDDTFYYRYSSVAAPPPSNPKHQPSSSAKSSAPGGGSGGLAPSKSTLYVSNLDFSLTNSDIHTLFSTFGKVARVTVLKDRHTRQSRGVAFVLYVSREDAAKAARSMDAKILNGRKLTVSIAADNGRASEFIKKRVYKDKSRCYECGDEGHLSYECPKNQLGPRERPPPPKKRGRRKEEEGEAEEISWSAAAPSLAVAEEEFEEENWASVVDNEAGERLRKREAEEEEERRMKRKEKKVSYFSDESDDED