lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MDRYMDRKLFVQLNGNRKVTGVLRGYDPFMNIVLEDASEELGDGEKNFLGSIVVRGNSIGVLEAIEKVAA
The following text describes a protein:
Function:
General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.
Subcellular Localization:
Nucleus.
Sequence:
MSKNCPECGSSRVVEDDLYSQKQWVCEDCGSVVSEGLLTTTLSEESHSRAVPFFTSTAAFKKPCRNLVSGFSRLRALCRIFRLSSSMEDASANLFERAYNHPNFLHISLSKKQILAGCCMFHICRQNSWPVFMGTIGYLLDADNYQMGTIYQELTKSLNLQTTQVCITRMLESFCYDFKLAPDEVEEVFSVAQQRLVDQTSALLELAADTWILTGRRPFPLFLAAVYVAWQSLNPLARMKYSLMKFCKIAKAPEQLWCKSKDTINKRLNELLEVLCKLGRELPWVRPTDIQMNTVTTLVEDILKHRKALLILAVKHYEKQLEETQTSQYSESELSDSKSSVQTQCKSPPDEEDEGCELPPDHWGKRHLFLPPCVRTQKRQKINEAPLEVTGDEDISDSEIESYIRSEEEIKLFAKARKKICKY
The following text describes a protein:
Function:
May operate as a cation/H(+) antiporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVRYFPSNGQTVLPIHLGFWPDNPSSPGDLIITKAFSAKLPVVCRHVHSKQPFGLFRGENAMNYAFSTFLLEAVIVIFFIKATCFILRPLRQPRIVCEIIGGMMIGPSMLGGSRNFSYYVFPPISNYIFTNLGLMGFFYFFFLTAAKTDVASIAKSPKKHKYIAAISVLVPMVCVGATGMAMREQMDKTMGKPSSVGGIAFALAFSSFPVIYTILRDMNLLNSEVGKFAMSVALLGDMGAILVLVFFEAVVQANVAGAKAAVFYVVSVVIFSAFMILVVKRAFEWVVDQTPQGKLVDQNYIVMILMGVLVACFLTDMLGLLIGTGPIWLGLIIPHGPPLGSTLAIRSETFIHEFLMPFSFGLVGLYTDVHFLSADAWDHQLAPLVYMTTVSFITKFISVAAAAAFFKVPTRDSLTLGLIMNLRGQLDIMLYLLCFRKHVVGLPGFTLLVLHTVVITGVSTPIISFLYDPNRPYRISKHRTIQHTPPSTEMGLVLAVSNQEALSGLITFLDFAYPTTSSSFAIYAIQLMELMGRASPVFIDHKLQKEEEDKEGDEEEGRVDQVQSAFKLYQKKRKECVTLHAYTAHAPKRLMYQDICELALAKKTAFILLPYQRERLEDNAPTELLDPGMLSVNADVLAYTPCSVCIYYGKGRLRNAKVRSSVDQQHSILPSRVRQETYRFVVLFLGGADNREALHLADRMTANPDITLTIVRFLSFNHEGEDVREKKLDDGVVTWFWVK
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MDFSFPSLLLLSPITTVLVSTSAVKNTPSISLDTHLSSLRNFCNNPDACFDSLKLSISINIDATYLLHSLQTAISTNLFVSAGGSNNVIEKQRGTIQECQQLHQITSSSLQRISVPRIQAGDSRKQADARTYLSAALTNKNTCLDGLYSASGPLKTVLVDPLTSTYMHVSNSLSMLPKPVPRKGHKNRRLLGFPTWISKKDRRILQSDDDQYDPSQVLNVAVDGSGNFSTITDAINFAPSNSENRIIIYVKQGVYVENVEIPMNKPNIVLIEDGSDVTFITGSRSVGDGWTTFRSATLAVAGDGFLARDMTVENRAGPEKRQAVALRRECDVAGTVDYIFGNAAVIFQGCNLISRMPMPGQFTVITAQSRETSDQNTRISIQNCSVVAEDVSYSVSTSAKSYLGRPWTEYSRTVILGCFIDGFIDPAG
The following text describes a protein:
Function:
Promotes the efflux of actinorhodin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSVEADEPDRATAPPSALLPEDGPGPDGTAAGPPPYARRWAALGVILGAEIMDLLDGTVMNVAAPAVRADLGGSLSVIQWITVGYTLAFAVLLVVGGRLGDIYGRKRMFVVGAVGFTAASVLCSVAAGPEMLTAARFLQGGLGALMIPQGLGLIKQMFPPKETAAAFGAFGPAIGLGAVLGPIVAGFLVDADLFGTGWRSVFLINLPIGVAVIVGAVLLLPEGKAPVRPKFDVVGMALVTSGLTLLIFPLVQGRERGWPAWAFVLMLAGAAVLVGFVAHELRQERRGGATLIELSLLRRSRYAAGLAVALVFFTGVSGMSLLLALHLQIGLGFSPTRAALTMTPWSVFLVVGAILTGAVLGSKFGRKALHGGLVVLALGVLIMLLTIGDQAGGLTSWELVPGIAVAGLGMGIMIGLLFDIALADVDKQEAGTASGVLTAVQQLGFTVGVAVLGTLFFGLLGSQATASVDDGASRARTELAAAGASTTEQDRLLADLRVCLRESASQQDSERTPDSCRNLQQARPAVAEATARAWRTAHTENFSTAMVRTLWVVIALLAVSFALAFRLPPKPREEEGF
The following text describes a protein:
Function:
Involved in localization of clathrin-associated adapter complex (AP-1) and subsequent AP-1-mediated clathrin-coated vesicle cargo loading. Directly mediates the interaction between LAA1 and AP-1 which is required for AP-1 localization. In complex with LAA1, cooperates with the small GTPase ARF1 and the phosphatidyl-inositol-4-phosphate (PI4P) synthesis to confer temporal specificity to AP-1 recruitment.
Miscellaneous:
MISCELLANEOUS: Present with 1320 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Note=Localization depends on ADP-ribosylation factor ARF1.
Domain:
The ear-binding motif (EBM) is required for the interaction with the clathrin-coated vesicle and its recruitment to clathrin-coated vesicles.
Sequence:
MSDRDQIEPVTNALDAESDSSDDFGNFSDASVENDLYNQNSTLTTSSESVVDNCLNKILPKGEFDLEEETIKNDCFKLSKLIEDERPHVIYEQLVQLDPVLQPFIWNKSHIRRNLLHILRLSDNNGSEGVGTKREEEPLNDELFKRICDAVEKNEQTATGLFLRDNFKIDYTPPMTLKSLQKEEEREQEQHIPQLLMADFTSMDEESLRQYHDTLCQSIDFLVSKSRSLKKQQRDLLKDKTTFENVVTNLTGHTQRLQRDEIALYNKKRNKKKRFSWVGY
The following text describes a protein:
Function:
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both fgf and wnt signaling. Inhibits both wnt and fgf signaling through the regulation of protein maturation and cell surface transportation of their receptors within the endoplasmic reticulum.
Miscellaneous:
MISCELLANEOUS: 'Shisa' was named after a sculpture form, common to southern Japan, with a large head similar to the Egyptian sphinx.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MWLEGSPLAVLAAVSFLLSVLAAAQGSGEYCHGWLDAQAVWRDGFQCPERFDGDDSTICCGKCELRYCCSSAEARLDQGVCNNDRQQGAPDHNRPDKDSPDSTAVPIYVPFLIVGSVFVAFIIVGSLVAICCCRCLRPKQEPQQSRAPGSNRLMETIPMISSASTSRGSSSRQSSTAASSSSSANSGARPPPTRSQTNCCLPEGAMNNVYVNMPTNFSVLNCQQATQLVQHQGQYLHPQFVGYAVPHDSVPMTPVPQFIDGLQGGYRQMQSPYPHSNPEQMMYPAVTV
The following text describes a protein:
Function:
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Sequence:
MELCFYNSKNGYLEALLRGFRSSFLTPEEYKKLTEADTLEDLKSVLEDTDYGTFMMDEPSPIAVTTIAQKCKEKMAHEFNYIRAQAEEPLRTFLDYIAKEKMIDNVISLIQGTLNKKPADELLSRVDPLGYFPQMKAITTMDVQNSYDDVLKVLLIETPIGSYFDQYISANSSNENNNVTTILSDMDIEILRNTLKKAWLEDFYNFIRKLGGKTEEVMGHILKSVADFRVLSVTLNTMNSSLSLELQKDRNDMFPCFGYLYPEGTDRIRKCWNNETVQAALEHYPTYYNLYEECKQFYMKNDNANENKIVDHKIKSLEDILYVKLVKLCETAFDQHCHFGIFYAWVKLKEQEIRNIVWISDMILMNRKDCIDSIVPIFEPHI
The following text describes a protein:
Function:
Found at the monomer-monomer interface of the photosystem II (PS II) dimer, plays a role in assembly and dimerization of PSII. PSII is a light-driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating a proton gradient subsequently used for ATP formation.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MEALVYTFLLVSTLGIIFFAIFFREPPKVPTKKVK
The following text describes a protein:
Function:
Voltage-gated chloride channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVEEDLNQIGGNSNYNGEGGDPESNTLNQPLVKANRTLSSTPLALVGAKVSHIESLDYEINENDLFKHDWRKRSKAQVLQYVFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGHFLTQERYVTGLMVLVGANLGLTLVASVLCVCFAPTAAGPGIPEIKAYLNGVDTPNMFGATTMIVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGTDNHRIKWRWLRYFNNDRDRRDLITCGSAAGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLREFIEICNSGKCGLFGKGGLIMFDVSHVTYTYHVTDIIPVMLIGVIGGILGSLYNHLLHKVLRLYNLINEKGKIHKVLLSLTVSLFTSVCLYGLPFLAKCKPCDPSIDEICPTNGRSGNFKQFHCPKGYYNDLATLLLTTNDDAVRNLFSSNTPNEFGMGSLWIFFVLYCILGLFTFGIATPSGLFLPIILMGAAYGRMLGAAMGSYTSIDQGLYAVLGAAALMAGSMRMTVSLCVIFLELTNNLLLLPITMIVLLIAKTVGDSFNPSIYDIILHLKGLPFLEANPEPWMRNLTVGELGDAKPPVVTLQGVEKVSNIVDVLKNTTHNAFPVLDEAEVPQVGLATGATELHGLILRAHLVKVLKKRWFLTEKRRTEEWEVREKFPWDELAEREDNFDDVAITSAEMEMYVDLHPLTNTTPYTVMENMSVAKALVLFRQVGLRHLLIVPKIQASGMCPVVGILTRQDLRAYNILQAFPLLEKSKGGKTH
The following text describes a protein:
Function:
Positive nitrogen regulatory protein. Required for the activation of transcription of a number of genes (including the allantoin pathway genes) in response to the replacement of glutamine by glutamate as source of nitrogen. Binds the nitrogen upstream activation sequence of GLN1, the gene encoding glutamine synthetase. URE2 may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.
Miscellaneous:
MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Sequence:
MQDDPENSKLYDLLNSHLDVHGRSNEEPRQTGDSRSQSSGNTGENEEDIAFASGLNGGTFDSMLEALPDDLYFTDFVSPFTAAATTSVTTKTVKDTTPATNHMDDDIAMFDSLATTQPIDIAASNQQNGEIAQLWDFNVDQFNMTPSNSSGSATISAPNSFTSDIPQYNHGSLGNSVSKSSLFPYNSSTSNSNINQPSINNNSNTNAQSHHSFNIYKLQNNNSSSSAMNITNNNNSNNSNIQHPFLKKSDSIGLSSSNTTNSVRKNSLIKPMSSTSLANFKRAASVSSSISNMEPSGQNKKPLIQCFNCKTFKTPLWRRSPEGNTLCNACGLFQKLHGTMRPLSLKSDVIKKRISKKRAKQTDPNIAQNTPSAPATASTSVTTTNAKPIRSRKKSLQQNSLSRVIPEEIIRDNIGNTNNILNVNRGGYNFNSVPSPVLMNSQSYNSSNANFNGASNANLNSNNLMRHNSNTVTPNFRRSSRRSSTSSNTSSSSKSSSRSVVPILPKPSPNSANSQQFNMNMNLMNTTNNVSAGNSVASSPRIISSANFNSNSPLQQNLLSNSFQRQGMNIPRRKMSRNASYSSSFMAASLQQLHEQQQVDVNSNTNTNSNRQNWNSSNSVSTNSRSSNFVSQKPNFDIFNTPVDSPSVSRPSSRKSHTSLLSQQLQNSESNSFISNHKFNNRLSSDSTSPIKYEADVSAGGKISEDNSTKGSSKESSAIADELDWLKFGI
The following text describes a protein:
Function:
May be involved in the regulation of dNTP production. Induces the SOS system when expressed in E.coli, therefore, it may play a role in DNA metabolism and/or in genome stability.
Sequence:
MKKTIYKVLVSFYQYVGLGKKFHPSHDTVLIIGGSSNELGIELCETFIEDYHTKVINIDTIDSINGKNARRSEKLYTFISCKDFSDIKCLEESMLYLQNLEIIPTVLINNMQEGIESTLLKEDKFLRLDEESLNEFEKIVRYNLQSVILITKFCLSNIFPKVQAEAQEKAKGFYIVNISSVLTLKPCKSGTHFITSKCGINSFHDGITSELKLKDSNLNVKTLIAYLPSFESEAHWKRLSPSISKHLVHCLLEGRYGDTILESKRSIGDILLITGFKSSFT
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKNSKFIDQFATFAGKLGNQIHLKTLRDAFVTVMPLYILAGLIVLLNNTVFKWIFQGDTLTRFQYWGITIANGTLSISGMIIAVMVGYFLAKNRDFENPLAASMLSLVSLIVMMPNTVSVVPDGAKDAVNISGVLSFNNTGTGAMFAGVIVAIIATELFIELSNVKALQMNLGENIPPAVSRSFSVLLPVMTVISLFGVVSALLFNITGMNLISIITIFIQEPIRHIGTSLIGVIIIYSLGNMLWLFGIHQAVIYSAILEPLLLINITENITAANNGQAIPHIINLSQIQTFALMGGSGSTLCLLIATFLVSRNAVSKNVAKLSFGPGIFNINEPVLFGYPIVYNISLAIPFITVPVLGILISYLATVTGFMSPAFIQVPWTTPVFLNAWLATAGDVRAVLVQFIIFALGVLLYIPFIKVNDKVVEQEMEG
The following text describes a protein:
Function:
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Subcellular Localization:
Cytoplasm.
Sequence:
MRILKKKMKLKGKVKKYLIDKLNDNEKLHFSLIDPFKINSSDELKYITKNLYNAGTDAFLIGGTLGVSKDKLDFVISLLDDYEIPKIIFPSNINLLSEKADALLFMSLLNSDDIYYIIGAQIVAAPIIKMLQMEVIPTAYVIVGHGGTAAHIGKARVIPYDNFELATAYTLAAEYLGMSFVYLEAGSGAPEPIRPEMISFIKNASSIPLIVGGGIRSVEVALKLVEAGADIIVTGNIIESDVNKAIKIIRGIKNK
The following text describes a protein:
Function:
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
Subcellular Localization:
Cytoplasm.
Sequence:
MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQGEHLSDQENAPPILPGRPSEGLGPSPHLVPHPGGPEAEVWEETDVNRNKLRINIGKSPCVEEEQSRGMGVPSSPVRAPPDSPTTPVRSLRYRRVNSPESERLSTADGRVELPERRSRMDLPGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSMQALAEEDLQHLPPQPLPPQLSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQVFSVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQVPLAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEEGSKTLVLVSPGDMKKSPVTAELAPDPDLGTLAALTPQHERPQPTGSQLDVSEPGTLSSVLKSEPKPPGPGAGLGAGTVTTGVGGVAVTSSPFTKVERTFVHIAEKTHLNVMSSGGQALRSEEFSAGGELGLELASDGGAVEEGARAPLENGLALSGLNGAEIEGSALSGAPRETPSEMATNSLPNGPALADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWSKRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQLQTPPGSATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEGRAGAR
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MTPNPMTNDLPDPAAAPDSAPLYSPARVRALLAAHGLKPTKSLGQNFLIDGNILRAIAEAGGAAPGENVLEIGPGLGVLTREVASRGARVTALEKDERLRPVLAETLAGLDVNVIWGDALDFDYAALPAGTRVIANLPYYITGLLLTRFMQAPGVVSATVLVQKEVAQRLVAQPGQDNYGFLSAVAALYGSVKHVRDVPKGAFFPAPDVTSSVVRLDFDRTRPQPDPAFVSFVDNALRYRRKTLRNNLRMMGHSGEAIDAALSDLGLRPDVRAEDVPLSGLRAVAAALGVVR
The following text describes a protein:
Function:
May be involved in BMP2-induced transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSALPPSSSSPAVLALHSATHKDTILHKFDTLRRSELLCDITLIVEDVHFKAHKALLAASSEYFSALFTAEEQVSQSLYKLDGMTANTFSSVLEFMYSAVVLVDESSSEQLMEMARFLVIPDLIKAHEDLQAVDEHMQVKRKRGRPKKNQDLSQKENPESELQAQTSSEIQEVNEEPASPATDGSDGEFNPREERRREGKRKIKQPIRLKGFRMDDLMEGKEPGKRGRRRKYPDTEARCEECGKVFKSHLFLKIHQRTHTGEKPFRCSVCGKEFTQKHTLLVHQRMHTGEKPYICTVCSKALSTKHSLLEHMNLHTENKLFTCEECGKSFSQQRQLKSHNRVHTGKGLPECAECHHKFMDAAQLKKHLRTHTGEKPFTCEICGKCFTAKSTLQTHIRIHRGEKPYVCKVCDKTFSDPSARRRHEVSHTGKKTFSCSICKVSFARKDNLKAHIKTHNKENPPAQAESTDKPPQSAPEQQEQEQQQQQQTSGDKELHSILQLQPFQLPAHGEQEIQLLVTGENLSLDQEQSISIITSEDTEQSLALLTQPSGHVQNLAVVTPDGNAQIQTISVLGGEVNGGDPEQMHVITLSKEAMEQLQVHHGAPQQLQVIHQLSEEQTGPVAGIHISGQSGQAISISQTTEQIPSDQIQGQTFQIQAGTVSYLYTTSMNPQN
The following text describes a protein:
Function:
Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Required for proteolytic processing of GRI.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MDQQGMVKKRLAVLVGCNYPNTRNELHGCINDVLAMKETILSRFGFKQDDIEVLTDEPESKVKPTGANIKAALRRMVDKAQAGSGDILFFHYSGHGTRIPSVKSAHPFKQDEAIVPCDFNLITDVDFRELVNQLPKGTSFTMISDSCHSGGLIDKEKEQIGPSSVSSNISPAIETTNKTITSRALPFKAVLDHLSSLTGITTSDIGTHLLELFGRDAGLKFRLPAMDLMDLLETMTAREKHVDSGILMSGCQADETSADVGVGNGKAYGAFSNAIQRVLNENEGAMKNKQLVMMARDVLERLGFHQHPCLYCSDQNADATFLSQP
The following text describes a protein:
Function:
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Component of several complexes which regulate chromatin metabolism (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSVHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPTSDVLVFDYTKHPSKPDPSGECTPDLRLRGHQKEGYGLSWNPNLRSCLLSASDDHTICLWDISTVPKEGKIVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHAVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGAADTEVQG
The following text describes a protein:
Function:
Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MISAQACGANGKMKDYHYSGPVEHKFSPYAFNGGTVLAVAGEDFALVASDTRLSEGYSIHSRDSPKCYKLTDTTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKSMTSGAIAAMLSTILYGRRFFPYYVYNIIGGLDEEGRGAVYSFDPVGSYQRDTYKAGGSASAMLQPLLDNQIGFKNMENVEQVPLSQEKAVQLVKDVFISAAERDVYTGDALKICIITKEGIREEIVPLRKD
The following text describes a protein:
Function:
Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation.
Subcellular Localization:
Chromosome, centromere. Cytoplasmic vesicle, autophagosome. Early endosome. Endoplasmic reticulum. Late endosome. Lysosome. Midbody.
Sequence:
MSSCASLGGPVPLPPPGPSAALTPGAPTRALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCDNEKICKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKEEAYQLLIEWKVYLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKAHPNAQKNLLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQRIGKEIEEKLRLTSTSNELKKESECLRLKILVLRNELERQKKALGREVAFLHKQQMALQDKGSAFAAEHAKLQLQKESLRELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRW
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MKKGEKEMEGNYYFYNSGEASHYYNQQLPMYDSSFVQPPSNSGFCCPDFVVGSSSSSSSVTNPFDHSRFPTPKSQFVDQFCVGPNVSDSSSSYYRRVNNGVIGGVMVDELGLSRDFQKLNVGNSDVVDNLGFRMSDCSSTNVAENFGVLGSFYNINNNNNGFSGNGGFQSSVYRDEKGVKDSRLGQRGGLNGNLGDSFGSNPGYPASVHGHHNCLINFPLDGMTQVGDDCWGNGGVSPLRGNKYIEPLSVYENGDFQGNVPIPRGGNVGYSDEIPFQMEPGFGPHIVGNGVPLQQYMIDGFTSWVNSQNLSMYNKLGLNEAALLEQYGRQYSEKMRAENLSRKNVLYNSMREKKMRVVEEREVSLMKRTRDLERNSILRDNKGSNNGVIGKSYQLSGRMKNLPSNIEERNFEQLNILFQSVKDCENGSNVVRFDPFVQTLYNSLIEVEGNIYIMAKDQHGCRLLQKMFDEGTFEDVQNIFNEIIHHVVELMMNSFGNYLIQKLLDVCNEEQRMKIIHVVTKDRGELVRVSLNTHGTRVVQKLIESLKTRRQISLVVRSLEPGFLDLTKDINGNHVVQRCLQCLSNDDNKFIFEAAAKFCVEIATHRHGCCVLQRCIEYSSGEHRQKLLHKICSNGLLLAQDPFGNYVVQFIIELKIPSATALLVSQFEGNYVHLSMLKCGSHVVEKCLKFYEDCHARIVYELLSVSNFDQILQDPYANYVVKSALESTKGALQESLLTAARAHSVLRTNPHCKKIFSRVLMKK
The following text describes a protein:
Function:
Plays an essential role in early embryonic development.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MQHDDVIWDLIGNKSFCSYKVKTKTQQFCRNEYNITGLCNRSSCPLANSQYATIREEKGQCFLYMKVIERAAFPSRMWEKVKLDRNYAKALEQIDENLIYWPRFIRHKCKQRLTKITQYLIRIRKLTLKRQRKLVPLSRKVERREKRREEKALIAAQLENAIEKELLDRLKQGTYGDIYNFPINAFDKAMEKQDEESESEEEEEEEDEEESGTREFIAEDEFEESDLSDFEELNNLKDSSDEEVNDEEESSEESEEESEEEEVKSKAKSKGKAPLKGPSRKKRAYVEIEYEQETEPAQKSKAT
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.
Sequence:
MAILKDTIIRYANARYATASGTSTATAASVSAASCPNLPLLLQKRRAIASAKSKNPNLVKRELQAHHSAISEYNNDQLDHYFRLSHTERPLYNLTNFNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFWDSKNRMATLKVLQNLCCNQYSIKQFTTMEMHLFKSLDWSICQSATFDSYIDIFLFQSTSPLSPGVVLSAPLEAFIQQKLALLNNAAGTAINKSSSSQGPSLNINEIKLGAIMLCELASFNLELSFKYDRSLIALGAINLIKLSLNYYNSNLWENINLALEENCQDLDIKLSEISNTLLDIAMDQNSFPSSFKSKYLNSNKTSLAKSLLDALQNYCIQLKLEEFYRSQELETMYNTIFAQSFDSDSLTCVYSNATTPKSATVSSAATDYFSDHTHLRRLTKDSISPPFAFTPTSSSSSPSPFNSPYKTSSSMTTPDSASHHSHSGSFSSTQNSFKRSLSIPQNSSIFWPSPLTPTTPSLMSNRKLLQNLSVRSKRLFPVRPMATAHPCSAPTQLKKRSTSSVDCDFNDSSNLKKTR
The following text describes a protein:
Function:
Binds and inhibits CYCD2-1/CDKA-1 kinase complex activity. Regulates cell division which is crucial for plant growth, development and morphogenesis. Functions in turning cells from a mitotic to an endoreplicating cell cycle mode. Acts cell- and non-cell-autonomously to regulate endoreduplication by allowing S phase progression, but blocking entry into mitosis. Keeps on the one hand the plant cell cycle locally controlled, and on the other hand provides a possibility of linking cell cycle control in single cells with the supracellular organization of a tissue or an organ. May target specifically CDKA-1.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing ICK1/KRP1 show altered morphology (including flowers) with a reduction in plant size, cell numbers, pollen germination, seed production and CDK kinase activity. Trichome cells misexpressing ICK1/KRP1 show reduced endoreduplication and cell size, and undergo cell death. ICK1/KRP1 degradation is regulated by the AXR1-dependent RUB conjugation pathway that is required for the function of the SCF complexes.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Distributed in a ponctuate pattern and in heterochromatic chromocenters.
Sequence:
MVRKYRKAKGIVEAGVSSTYMQLRSRRIVYVRSEKSSSVSVVGDNGVSSSCSGSNEYKKKELIHLEEEDKDGDTETSTYRRGTKRKLFENLREEEKEELSKSMENYSSEFESAVKESLDCCCSGRKTMEETVTAEEEEKAKLMTEMPTESEIEDFFVEAEKQLKEKFKKKYNFDFEKEKPLEGRYEWVKLE
The following text describes a protein:
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking.
Subcellular Localization:
Cytoplasm, perinuclear region. Lysosome membrane.
Sequence:
MELDDAVLYQDDPGSSAVMSERVSGLASSIYREFERLIEKYDEDVVKELMPLVVAVLENLDSVFAVNQEHEVELELLKEDNEQLVTQYEREKALRKHAEERFIALEDSQDGEKKDLQARLVTLQSVVRQMELKTKNYADQIGRFEEREAELKKEYNALHHRHTEMIHSYMEHLERSKHGAAPAEPADPASSARTRRERPLSMGLFQLPGGEGLTSDLHRDPLESPSEPWRFSSLSHPRSNTSLKDELAHFPNGRSKSGSSTNHVSRTGASESKPSSSAVPPSRTGPASSSVIADVSLESLVKPPQDPEPSEQQNLDLNRVFLEGTQTSAARREGGWGQFGSDDQESAHPPLQGDDGSEAAEPSEVQAIIESTPELDMDLEGCRGTSTPTKGGVENPAFNRNTDSLFEELSSAGNDLISDMDDGADLLDEFSDGSYLGMGREVEHLIHENAQLLETKNALNVVKNDLIAQVDDLACEKEVLRGELDAVIQAKTKLEEKNKELEEELKTVRAELEDAKQKVKNENEDDSDVPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASKENPALPEKKKSSLWQFFSRLFSSSGGGGKKPAAAAEAPVNVKYNAPTSHIQPSIKKKSSTLQQLPSDKSKAFDFLNEEAPAESVVTRREQKRAQYQQVKAHVQKEDGRVQAYGWSLPKKLKGNGAQAEKMKNLPVPVFLRPLDEKEASMKLWCAAGVNLSEGKTRDGGLLVGASVFYHDLSGSEGPQKKAGSQSSLEKLDQELQEQQKELQHHDRLSSLVWICTSTQSASKVVVIDANQPGNILESFVVCNAHVLCITSVPGARETDYPAEEEGAPNPEAGPAGDGSSASADSSSPSGDSILGGITVVGCEAEGAGAGPGENLCVDSRAAQEPAGESLRSVHADTSFSDPLGAGEGSLEREGEPPRDGAESNPEQEEQLTMEEAQRMSSVQPTMWLGAQDGHLYVHSSVAHWRRRLHSIKLKESVFCIVHVKGRVLVSMSDGTIAIFRRGADGQWDLGRYHLLDLGRPAHSIRCMTVVHDAVWCGYRNKIYVVKPKAMRVEKSFDAHPRQDSQVRQLAWHGDGIWVSIRLDSTLRLFHARTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMMSCNRLWIGTGNGVIISIPLTETASKASKAAGNLPGAVVRLYGDDSGDRVTAGTVIPYCSMAQAQLCFHGHRDAVKFFAAVPGHAVPPSSSGGEAAGEKSDASCQEGMKSVLVMSGGEGYIDFRIGDEDGEAQEADAALLKLQASPAKAERSHLIVWQVLLSGE
The following text describes a protein:
Function:
Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER). Specifically required for the cleavage of the final glucose. The subunit beta retains the catalytic subunit alpha in the ER (By similarity).
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MVRLNLAVVALAAGALSASASASSSATPLRGLLTDAAKYQPTKDAQSQLRWKCLDGSKELSWSAVNDDYCDCPDGSDEPGTSACPNSSFYCHNTGHMPAYIRSSRVDDGICDPECCDGSDESDGKIRCPNRCEKVGKEYRKKLAELDNLRRAGAKVRDKYIAEGRKQKELLHAEIAKLEIEVQVATENEARFKAELTRAETSDKALIDAKVKTPLYTKLVDYQNAIRALHVKNAALKAELQTLTLLLDDLAKGYNPNYQDMAVKGAVVAYKEWRGIASAAAAATATGEVKEEGENNVDQIAGENTKLNELLDEGDWPWAKLSTLLSDDPLDLMDRGLGGALDDKRVYASETDGGLLFRIHEYLPDGIVPYFEAMVDTLLDVLMKANVITDVKRMRPKSSVGSESEPETVSVARRAHTDAAAHLSRTTHELSSLKQKLSEFSTRYGRSAEFKALENKCFSKDMGEYTYEYCFFGRATQIPNNGGAQISLGTFTNFNPKHDKSADEDAYWLQQIYARGQKCWNGPERSAIVDLECSTENKVLDVFEAEKCIYSIKVATPAVCFPPQQQQAQQTQQDGGHQVKDEL