lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.
Subcellular Localization:
Mitochondrion. Mitochondrion intermembrane space.
Sequence:
MVKYFLGQSVLRSSWDQVFAAFWQRYPNPYSKHVLTEDIVHREVTPDQKLLSRRLLTKTNRMPRWAERLFPANVAHSVYVLEDSIVDPQNQTMTTFTWNINHARLMVVEERCVYCVNSDNSGWTEIRREAWVSSSLFGVSRAVQEFGLARFKSNVTKTMKGFEYILAKLQGEAPSKTLVETAKEAKEKAKETALAATEKAKDLASKAATKKQQQQQQFV
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAEDLKLIRSEFCPYCLRIVLAVVMKRLQGRVEEEDLSNKSALLLESNPVYKKVPVLIHNGKAIAESLVILEYIDETWPEPPLLPKDPQERANARFFAKFVDEKIVPTADKVLTAKEEEKDGILKELHEQMMFIEKELIRLESVGDGRLGYFDIVVYFIFYEFLLIKQVTGIELIDFDKLPAITQWMGLLGEVSTISMYCLPPEYKYIDSIRARIEAAKSASE
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MAFYIFLRTYNYYDGKEGVKRVEVSNDSKINVLKNYVPPMESPIVFFKGTNKLNLHKYFQDYSIQQDDIIDSTLFPIESTILGYIGKLIVEEHRGILHKPPPQAIAQIPQLRKKLRVLDFEEYFDVDTTYTRLKLLLQKHKISTGKHFEKEISEYSNQDEQKQDPLDSFICRVYNRNPFNINNYSQNNNNNGYRNINTTTTTTTTTSPNKNNYSTTYNDEVMLSQPKTIFTQSDCIIIDDNEENIDSKKSNNKHSLNIPSDDSFNSNSGLKSSKNSLNNSFNNSLNSSLNSSLNSSLNSSFNNSLNRSLNSSLNSSFNSSFNNNFNNFNIRNSINLDDDDDDNYDYFESKTQSQSQSQSQSQSQSQSQSQSQSQSQSQSQSPKLQNNIKQLPIQSKLSIESESDEIFSYQNLSLNSSAINKRKQISNSSSSFFSDSSVNGSPIMPTSPLYNISPIKHDNNSKPINKIQKIDSILNRPLFSDKVYNEKKKLKQNYLPPLLKLEAPLPQRFKVRSRYADWSDSAFGLQYSLLLGLKELKTTINKKVSLSTIEKHSQKYTSIWDLRDFEFTISNNRPIIALTTQLVDRNLVEEADIEEDNLPEEDQEKFYIRDLGYRYACILEDFHKDFQEFCNINNFKTNFKQTSITIVVDSAEKKRSSFRNNFKEFGVDAIERTLPSGDFVFLKTSNKDEMYPYLFERKTWSDFLGSIKDGRIVTQTIKMKAYTKLVGRFYIIEGDEENYSGLLKLFNIPIETLKKEIDFLTGFGFIVIRSQSIYDTSRILSIIAKIISDDIGLSCLTFPYQDFCQAVGLAKGDAYTAKIKSSERSKLEELANFNKGNKRCYFELTHEQLKGYILSNSYRNKVNETLRVSKREKIGIILAIRDFNQFIQNFVANHTEILSEYLQARLDSRDVNNLEKSYRSGVLKLADYLEINTVTYHLLELVIKNGLQLISNFTRSEKDNLEFIAEFSSTISQNLELDNQEKLNLLVNPKKISKFKTKKNNFINEIININ
The following text describes a protein:
Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
Subcellular Localization:
Nucleus.
Sequence:
MAAMAAGPGGGEGEAGAVSVELRRERRLVCVEYPGEVRDVAKMLLTLGGEEGVSRIHADSAKRLELYFRPKDPYCHPVCANRFPTTSLLLKVKRKKSRRRRLEGEGATVQEVKFDMEILGIITTIYKFQGMSDFQYLAVHTGADGQHTSMYDKVLLHKPEKEEYFNQELPLYIPPPIFSRLDTPVDYFYRPETQHREGYNNPPVSGENLIGLSRARRPHNAIFVNFEEDEVPTKPLEAAVQMWKKVCTNPMDRKVEEELRKLFDVRPIWSRNAVKANISVHPDKLKVLLPYLAYYMITGPWRSLWVRFGYDPRKNPEAKIYQVLDFRIRCGMKYGYAPNDMPVKAKRSTYNYSLPITVKKTPSQLITMHDLKQGLGASGTAKKSVSSKYKLKDSIYIFREGALPPYRQMFYQLCDLNVEGLQKIIHRNDGQEAECTERDGWCLQKTSDELRDTMSLMIRQIIRSKRPGGYRGAPGGSARGRVSGLGAGWGQFSQRPPAREPTHKRACDIGLAPWRRAGPSRSPGSWLSGGRLSPAARASLDPLPPRLSP
The following text describes a protein:
Function:
Suppresses the mitotic cell cycle in oocytes, forcing them to undergo meiosis II to produce haploid gametes. Acts as a MAPK kinase kinase (MAP3K) that acts upstream of MAP kinase in oocytes.
Sequence:
MPCDTADNWARYEGQDNAIMVARRGSVNSAFVTNSSQYHQAEDTNGNCFINARNDNWDNRDCNACVGHSDFSIDGVIGSGGFGSVFLGRYCGRRVAVKSVRQCSRNKEASRQSFQAEFNALLLRHDNIVSVLATTAYEDFDSGAFIIMEYAGRNLQQIVNDPGSSLSPTRRTKYALHIIRALHYTHSQGIAHLDVKPANVIVDSNTDVCRLADFGCSQRVSEGEGRDSFTSRSYLTGTFAYRAPELLRGRPPTTKADIYSYGVTLWQMLTRETPFAGENHHVVIFGVVAQNLRPSLPENANDAWYESLVTRCWEGRVADRPSAAEILLALERRTDDTENLPRDLKRRHGTT
The following text describes a protein:
Function:
Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage.
Subcellular Localization:
Cytoplasmic vesicle. Cell projection, axon. Cell projection, dendrite. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites.
Sequence:
MAAAQGPVSCEPDTRVLGTYLSSVPIGSMGSVGSLVEKQDLSPLELRAPLGGTRGLRQPDGLLRKGPSQRELFGYLHGAKKETRSERKHQASAACYKRDYESDRENRSPERCSREHHRGADFSKSSLPERGRFDKCRIRPSAFKAVTGKGLVSMQGLSSSKGQKLSKSNGSLHTLLSQSTTAAPQHGPLRTHLLHAISLDEASDSSHNSIQSFPSYGSRLKPAQSQFSASMGHINHIGGSLDRVSRSPRDPLAPEKAPLSCKSMATLSRLQSPGEPPPPYEFTYSLEDAVKQLEDRLKETGGELRQLKRSLSETEDPFAQAFEDKQRLWLDELEDLKQMYMARLQQVTQQAQRGQRALQLQLYKAQQEKKRLQEELSMQQCQCEETKLRQSQGERVSPKLEETKWEVSPLLSLSVATLQAVQPGWGSGSLL
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MALTGKMGSHERAGTAQYERAGSYKKSKRHTKDKKLNSKLQRIDRQYKEAIQSAAGTDLLLQEEQGFLEAENDMEKTFKFKQDEIADAVDSSTANKKFELKLPEFGPYTIDYSRTGRDLLLGGKKGHVASIDWRKGKLGCELHLNETVHAVKYLHNDQYFAVAQKKYTFIYDNQGTELHRLKQHIEATLLDFLPYHFLLVTAGHTGFLKYHDVSTGQLVSELRTKLGPTQAMKHNPWNAVTCLGHGNGTVSMWAPNMPEPLVKLQVARGPIRDLAIDREGKYMAVAAADKTLKIWDIRKFKEVDNYYSQTPASSLDISDTGLLSVGWGPHVTIWKDILKGKHQSEPYMNHLIPGSKIEKAKFVPFEDILGVGHEEGFNSIIVPGSGEANYDALELNPYESVKQRQQQEVRSLLDKLPADTIALDPNVIGTVDKRASTVRLKPGEITELADKTQQSKDKMEIKAEVKGKNSALRRHMRKKTQNVIDQRKLRIEKNLKMEKEARQRRRNLEQGIPEEKDLLGPALARFK
The following text describes a protein:
Function:
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.
Subcellular Localization:
Periplasm.
Sequence:
MKTKLIKILTPFTVLPLLACGQTPVSNANAEPAVKAESAGKSVAASLKARLEKTYSAQDLKVLSVSETPVKGIYEVVVSGRQIIYTDAEGGYMFVGELINIDTRKNLTEERAADLNKIDFASLPLDKAIKEVRGNGKLKVAVFSDPDCPFCKRLEHEFEKMTDVTVYSFMMPIAGLHPDAARKAQILWCQPDRAKAWTDWMRKGKFPVGGSICDNPVAETTSLGEQFGFNGTPTLVFPNGRSQSGYSPMPQLEEIIRKNQ
The following text describes a protein:
Function:
An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MNGIEWSALLKRIQEITAFFSITVNFLLIYLIVTKSPKNLGAYKYLMVYISVFEIVYGILDVILAPQHYSHGPTFLVIVGTQDKMFGPETLTILNACWWGFFGASMAIFDVHFVYRWLVVSEHHLLESFNDWRVVLWFSIPLWYGLTWVCTGYFLSAANESTSRFIKDNIKQKFGWDFNDYIYLGPYLYEVLEDGSYDFHWMAFLGQGIITATIISSVVIVLVFGYRCYDRISHLVATSSSSARFQKLQRQLFYALVIQTFIPFVLMHIPGAIMVAFVFMNIDLGVYSAVLSMTIAIYPAVDPLPTLFIVESYRKALLRFLRCQKKTKPNVSSVATISSRF
The following text describes a protein:
Function:
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Subcellular Localization:
[Isoform 2]: Cytoplasm; [Isoform 3]: Cytoplasm. Nucleus.
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
The following text describes a protein:
Function:
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
Subcellular Localization:
Apical cell membrane. Basolateral cell membrane. Cell junction. Cytoplasm.
Sequence:
MEGNGVPWGSEPVSGPGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCPSSPTSGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEITDSSTRRTESERSLLYRQLIDLGYLSSSHWNCGTPGQDTKAQSVLVEQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMDRLCKSNSEQPNRGLDDST
The following text describes a protein:
Function:
Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Domain:
Can be divided into a N-terminal domain with significant homology to S100-like calcium-binding proteins, a central domain containing a series of short tandem repeats, and two flanking segments with low homology to the consensus sequences of the central repeats.
Sequence:
MPQLLNSILNVSKVFQDYAEYHGVGASLSKKELKQLLLTEFGDILRRPNDPETVETILEHLDRDRNGYVDFHEYLLLVFQLVQACHHKLDSKFYGSRTSSQKEHDQEGTRSHKFSESTGRQHRQRYEGERRNSHHNQSEGQHQNVQHDQSQRQDKDSERHDTDPHCGQSETFHGDSHYGHSERQDTDYSSDQSESDNESSSSSQRLGYKSSHEQPKGQGYVFALSQSKNPEQAFHYGQSKTSGQQSSHGQSGRFRKDSYSSQTSQQESDSYEQYGSQHQKSGNSQTERQGQNSQYGQTNKKGHSSYHEQTEGQGQSFHYGQKGRKDQSFQQGQKGRKDQSPHLGQKGRQDQSPHRGQKGRQDQSPHQGQKGRQDQSPHRGQKGRQDQSPHQGQKGRQDQSPHLGQKGRQDQSPHQGQKGRQDQSPHQGQKGRQDQSSHQGQKGRQDQSSHQGQKGRQDQSSHQGQKGRQDQSSHQGQREGQDQNSQWHRTDSQGQSFHYGQTGGHSLSSHQGQTDSQGQNSNWHRTDSQGQSFHYGQTGGQGLSSHQGQTDSQGQNSNWHRTDSQGQSFHFDQAGREVQGSHHGQTDRQSQNSNWHRTDSQGQSFHFDQAGKEVQGSHQGQTDSQGQSSHWHQTDRQGQSSQQGHKDRQGQNTHQGQKGRQDLSPHQGQKGRQDQSPHLGQKGRHDQSPHQGQKGRHDQSPHQGQKGRQDLSSHQGQKGRQDQSPHLGQKGRHDQSPHRGQKGRQDQSPHQGQKGRQDQSSHQGQREGQDQNSHWHRTDRQGQSFHYGQTGGQGLSSHQGQTDSQGQNSQWHRTDSQGQSFHFDQAGREGQSSHHGQTDRQSQSSHCGQSEIGKTENQGQNRHSLGTDRTRRDSYVEQSGRSVKLSQQNSREEVRQTQSQRSHDRREQQIQQQTWKPKEDNQHKLLAQVQQEPYSYEEYDWQSQSSEQDHCGEEEYQDWDRHSVEDQENLYEMQNWQTHEEEQSHQTSDRQTHVDEQNQQRQHRQTHEENHDHQHGRHHEDEHNHRRQDHHQQRERQTHEEKEKYQGGQDQSRSFPNREKSHMSEDDQCEGPQGRRFHPTHGGGKSQRREKSGNHPTKPANYSSPLYDYVQEQAAYQY
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MEKDTEELELENAVFGNINNFSSFLDKENETFDVMMNEAPELSEDNDAQEDELEKLEDAELFMFDTGSADGAKDSVPLDIIAGDNTVKEDEEASNEIPSIWEDSDDERLMISLQDHSRLRKLRQYEDEDMVNGLQYARRLRTQFERVYPVPEWAKKQDVTEEEDEFNALSEKSVIPKSLKSLFKSSVSYINQSSKLLAPGTINIKRLKDANFQAPSHSGIRCMSIHPYFPLLLTCGFDRTLRIYQLDGKVNPLVTSLHLRSSALQTALFHPDGKRVIAAGRRKYMYIWDLESAQVQKVSRMYGQENFQPSMERFHVDPTGKYIALEGRSGHINLLHALTGQFATSFKIEGVLSDVLFTSDGSEMLVLSYGAEVWHFNVEQRSVVRRWQVQDGVSTTHFCLDPSNKYLAIGSKSGIVNIYDLQTSNADAAPKPVTTLDNITFSINSMSFSQDSQVLAIASRGKKDTLRLVHVPSFSVFRNWPTSATPLGRVTCLAFGKGGELCVGNEAGRVGLWKLAHYD
The following text describes a protein:
Function:
Transcription factor (By similarity). Involved in activating or repressing transcription of genes in neurons. Regulates expression of nuclear hormone receptor odr-7 and LIM homeodomain protein lin-11 in AWA and ASG chemosensory neurons. In concert with lin-11 and forkhead domain protein unc-130 plays a role in specifying AWA and ASG cell fates. Plays a role in modulating dendritic morphology and functions of AWA neurons. Involved in regulating GABAergic motor neuron development, acting in parallel with nuclear hormone receptor unc-55. Required to maintain the functional and structural integrity of the amphid organs during larval development. Plays a role in anterior hypodermal morphogenesis. Required for touch sensation. May act as a transcriptional activator in touch receptor neurons (TRNs), forming a positive feedback loop with transcription factor mec-3, thereby restricting the variability of expression of target genes such as mec-3. Positively modulates expression of H3K4 demethylase rbr-2 in early embryogenesis and during larval development.
Subcellular Localization:
Nucleus.
Sequence:
MPELKKEDSSKDEKDLDMNCPPLHRPNGADLNQYSKSLMEQLQAQLFANPALQFPSFPPAFSIAALTNNQHELKEDDGKKTPTGDNILEAASVLDNRENGSPSDGTNSPDDNGKRKQRRYRTTFSAFQLDELEKVFARTHYPDVFTREELATRVQLTEARVQVWFQNRRAKYRKQERSSTHHPYQAPMSIPNSNGDNPYQMMLSQEAIFAAINQQAAAHLLNEQVRIATSDRRSQSPSVPVTTSSPILPTSVTPTFQNADALNMLFGGITPVTQQLLYVQQFSRAMDAFRTQLLGSVPAGATAEVTDVVALKTEDSKSNSRAGSSSPTPTESSGAAATSTSPTNFADMNSLISDVKPKEESS
The following text describes a protein:
Function:
Transcriptional regulator which plays a role in the expulsion step of defecation by controlling enteric muscle-specific expression of exp-1 which is required for enteric muscle contraction. Not required for exp-1 expression in the PDA neuron. Also involved in controlling the length of the defecation cycle.
Subcellular Localization:
Nucleus. Cell projection, axon. Cytoplasm.
Sequence:
MNPHTNLNNVFDFPDLPMLLPKSEALSVTTDFSVPPVQQGAQQFHPPRNLGPQLARRWSCGDSQHADEPPASYYHNLGVALHNHFQMSNQHYLSDFDCPTTVSPISSAHETGQLPQLSPYDHIGNQDPHMFSPHAYGNSMIPDNSYFENASRSISAPNVGNSTLNPSLMSSDNAQSCGGRRRFRTNFTELQSTFLEDSFKESHYPDHKAKKYMADFLKIPEDRITVWFQNRRAKWRRKEHRQRDRTRNESFSGGSNSFDFACFSAQHPDDGPNAKHPNSFGIPNQPMSLDQFPMNTEQDFPEFPSLQEHQ
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MSLLRPRHHLSTLTAFTFLVFFSASATTVLLSQLGSGSLQEGGEDKGKGSGLGAFPRVLTQKRHGGPGSSPPSCRSKCDKCSPCEPVHVPIQHGWRMPLEYYPEAWRWSFGNVSCCRGEVTIPRGQDTSLSLSLSP
The following text describes a protein:
Function:
Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Subcellular Localization:
Secreted.
Sequence:
GIFSKLAGKKLKNLLISGLKSVGKEVGMDVVRTGIDIAGCKIKGEC
The following text describes a protein:
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence:
MMMNKIVLISLFLPTAFQLTWASCNNSLITQKAYFDVAIGNEYWGRIVVGLLGDTTPITVLNFATFASNHNNKGYSGTIFNRVYTNMAIQGGDILFNNGSGSTSIFNGGEDFPDENFYFSNDRGFIGMANRGANTNGCQFFINLAQNTFLNNIYVVFGKVLSGLDVVDKIASLPLDDKGVPLVPATIVGSGTFHPKEPFPVPIGTYF
The following text describes a protein:
Function:
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLSATPLYGNVHSWMNSERVRMCGTSEDRKIPVNDGDASKARLELREETPLSHSVVDTSGAHRIDGLAALSMDRTGLIREGLRVPGNIVYSGLCGLGSEKGREATPSSLSGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAESLGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYGLAQPLYSPVCTSGERFLYLPPPHYVNPHIPSSLASPMRLSTPSASAAIPPLVHCSDKSLPWKMGVNPGNPVDSHSYPHIQNSKQPRVTSAKAVNSGLPGDTALLLPPSPRPSARVHLPTQPAAETYSEFHKHYPRISTSPSVTLTKPYMTANSEFSTSRLSNGKYPKALDGGDCAQSMPGHTRKTTVQDRKDGGSPPLLEKQTVTKDVTDKPLDLSSKVVDADASKGDHMKKMAPTVLVHSRAASGLVLSGSEIPKETLSPPGNGCSIYRSEIISTAPSSWVVPGPSPNEENNGKSLSLKNKALDWAIPQQRSSSCPRMGGTDAVVTNVSGSVSSSGRPASASPAPNANANADGTKTSRSSVDTTPSVIQHVGQPSSTPAKHGGSTSSKGAKANPEPSFKASENGLPPTSIFLSPNEAFRSPAIPYPRSYLPYAAPEGIALSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLHTSRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRSRFSEMLEASSTKLHPEVPTDKNLKPNSSWNQGKTGVKSDKLVYVDLLREEADTKTDAGAPKAGLVAENVGQDTEATKPSADPVIQQRREFISLREELGRITDFHESFTFKQASSQPVFSLGKDSGAAGTNKENLGVQVATPFLETALGSEGPAVTFGKTQEDPKPFCVGGAPPNMDVTPAYTKEGTDEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSELEMKEREGSHPATKDSEVCKFSPADWERLKGNQEKKPKSVTLEEAIADQNDSERCEYSTGNKHDLFEAPEDKDLPVEKYFLERPPVSEPPSDQGVVDTPHSPTLRLDRKRKLSGDSTHTETAVEELAEDPLKAKRRRISKDDWPEREMTNSSSNHLEDPHCNELTNLKVCIELTGLHPKKQRHLLHLRERWEQQVSAAESKPGRQSRKEVAQAVQPEVTSQGTNITEEKPGRKKAEAKGNRGWSEESLKSCDNEQGLPVLSGSPPMKSLSSTNASGKKQTQPSCTPASRLPAKQQKIKESQKTDVLCTGEDEDCQAASPLQKYTDNIEKPSGKRLCKTKHLIPQESRRSLQITGDYYVENTDTKMTVRRFRKRPEPSSDYDLSPPAKQEPKPFDRLQQLLPATQATQLPRSNSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRSEDDTSGAWEFYGSSVCEPDDESGYDVLANPPGPEDPDEEEDTYSDLFEFEFAESSLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRSNFPNLEIVTIAEAEFYRQVSTSLLFSCPKDLEAFNPESKELLDLVEFTNELQTLLGSSVEWLHPSDTGHENYW
The following text describes a protein:
Function:
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA), the second step in tryptophan biosynthesis.
Miscellaneous:
MISCELLANEOUS: Present with 1760 molecules/cell in log phase SD medium.
Sequence:
MSEATLLSYTKKLLASPPQLSSTDLHDALLVILSLLQKCDTNSDESLSIYTKVSSFLTALRVTKLDHKAEYIAEAAKAVLRHSDLVDLPLPKKDELHPEDGPVILDIVGTGGDGQNTFNVSTSAAIVASGIQGLKICKHGGKASTSNSGAGDLIGTLGCDMFKVNSSTVPKLWPDNTFMFLLAPFFHHGMGHVSKIRKFLGIPTVFNVLGPLLHPVSHVNKRILGVYSKELAPEYAKAAALVYPGSETFIVWGHVGLDEVSPIGKTTVWHIDPTSSELKLKTFQLEPSMFGLEEHELSKCASYGPKENARILKEEVLSGKYHLGDNNPIYDYILMNTAVLYCLSQGHQNWKEGIIKAEESIHSGNALRSLEHFIDSVSSL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MATERIIENKPESHKHQKKNDPFMSILTFHCRLLRCVSRCFTATTTTSYPATRHDGYTKLTKHTNTKRTIILDLDETLVHSTTQMPGVKYDFMVMVKMESEIMPIFVVLDKLDKKGVISQRLYRDSCTELNGRYVKDLSLVVGKDLGSALIVDDNPSAYSLHPENGVPIKAFVDDLKDQELLKLLEFLEICYVYEDMRDAVQDLLPNRLM
The following text describes a protein:
Function:
Probable component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The PCI domain is necessary and sufficient for interactions with other CSN subunits of the complex.
Sequence:
MHLNKYSEVVERLENEEFEQVELGAEVYQQLLAIYLYQNKLADAKLLWMRVPANLRDDKELIQLNLLNIALQNNNYADFFKHIKYEWSERVKSPVEDLLNKQREELFKLMGSAYMSIYQHNLLELSLMSEDELKHACAALNWTEELDGDRVILKPKVQEAPPARGNDDQLLKLTEFVTFLEN
The following text describes a protein:
Function:
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLIATLAEK
The following text describes a protein:
Function:
Required for the assembly of dynein arms in the distal portion of flagellum axoneme.
Subcellular Localization:
Cell projection, cilium, flagellum. Note=Localizes to the distal portion of the flagellum.
Sequence:
MKKSTVLDARPTGPLPRRPQQPSPVEVRNSSQVEKNNARGSWRKLSPLGRQQEEQGGLIHSQSQSLDTSFAPNTNTTLGSTDVNLNSGVRDRPSPRHSIMHRRETRPLLPSNPTDSGVYASEDCGSSSAGFPRFSSMGNIDKSRDNGQLPDGLCTGGSEVTHSSAVHGEAITDELLRRLTRCSDLKSVSSAQFQLDFGTLRCVESISARMPQLNSLKLNNSRITELRVLGTNYANLRRLWISNCLVSSVSGVGACAPVLEELYASFNSISDIDALTEVSSTLQVVDLEGNDIRDTDMLKRTLPQLKKMKHLVLKGNPVASSETIVELSHSSEEKGTRQRKVSYSKLIGHLMPDLQYLDDAEISNTSLQKSARVQKKHHSAHVDPLEICIRDEYLFVQECIRECGFDALGASGADEMHGSCSRSNVSLISSRSHQLKQNRPSYDRNRPSVAVRSLRKNSQSTASSGDSTNQGCDGGKPRPSCQRWGPTQRTSRLFTGRVTSVGAPKARCRQLPPLKETPASPSTEGLGNEPGNDGQRQQESGAMMQLALKPVPPDANSTRGERKQQNTTSPICGLTAAKGNVYAFDVCDDDDDELEKSKESLMHRVRLGNSATSQQATFMGSGTAKSTNSELADSGLSFLLHRLSTCTHPSGADPPDQRNEQQQEQPTTAGATSRCLDDLETPGDGPLESLNGTPEKDWEWRRELMQSVVDIRKMTSEAALKERVQGSKEVDGGGLEKVESEDEEDVSPVVF
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPITRYQIRNEYSLADPELYRAADKDDPEALLEGVAMAGLVGVLRQLGDLAEFAAEIFHDLHEEVLATAARGHGLMVRVQQLEAEVPSIEKAFLSRTSHSQFIYNRGVDWHPNLRMDQNLVSRGDLPRFVMDSYEECRGPPRLFLLDKFDIAGAGACLKRFSDPSFFKAELTSSESKKAEIQRDKRARKVKKKGSRWRNGETPEALPVPHTKLHQLLLEERRQTENNAPGHRAKLKKRQSNQFPFGSTTGKSYMEKFVEMHSPECKIVCESSLTYTNLQMASKETSELVPEIHEIGTADPPYKLLQGKRSLVMSHIKQEKELEPSMKELHEDAVERGILKKLPEPITYTEIEKIPYTFYKPQDQKESSENEKEPVVDMGRKLEAIGDGYRSDDILYTFYKPQDHKESSENEKEHVVDMGEKLEANGDGYRSDDITSEVDNYMDALATMESEMETDTESKTKKERGIFSIERQGIDSDTNEEQLELQNQFLDSHSVGESSSSDNGKTSFRKGRSSFSNLDTLSTSANNAPSDGDVAAKVYPSIDTCLGERADVSSKMFSVDGDSLAIESSENVIRNGSCNEVSEVPSYKSEFSQRSSSSVTDQSQLSINLGELHLQQPELDEISYDSLKAGTKGSSIDTFLAGLADVSSKKHGNDLEIKSSENMILNGSCNELSDVPSYKPEFGQASSSSVTDSASISSHLSINLTELHLQGPESDEISSDCLKAGTKGSSSTIEDDRKNSIMDLSCPTNVSDLSSEVRDSFLHLGSAKGEPVEELDGVKNDFLHSVSDKKQLMEELDGGALGRSPAASLNLSYISNLAPEREDNGTSFEEVHPTGYPEDGSTENLDSQNSVILPTEEQVHDLVGHDLEANIDTVQPEYLPCTTCDDLEDVNPESKVVETDTVVLLTGKNSRYCEDSSAGSSDSPYAVLPTEEHFEGLSGGDVEASACSAPLEHACTTLEHLPASIAAGSVEIAESDVDRVTLSTAVNSEYLKPELYILSDAESDIPRIGHFVEDDVLERKIKVPPLELVQEADGKDHSEVKMNSNNLEEQPSTCDIMLKDEARLDVPGSTDWVPSVESDQEKYGNEHSYVKTSSNNLELLSDTSDIRIKDEPRSGMVHLSPCDSMGISALCLGIPSICDVPSSPKPALNETHLDDLTTETVHAETDGYDDADKDDAVSEAVHADINDYDDDDVHPNLIGSPSSNQIKLQEEYICNGNSEQSELEVTEACGTKHILEPDDQKEVNQLEIITEDLKFEHCRMEFHDTYSSELTASAHDSLKSNNLSSTSESLDVHDHALLVEHATSNLYLNDGLCAPTPSNKTNQECEPKPTNQRNLSESAEDVIPSSTSLLPEGGIPSEQVLELQVDKPSIDSSHDGENSRSSYLQCEQTQSPNHIDYNGCFTVPSESSSVDSFNQYTEPVLSPQPTTQNFNMSKQAMDPLDSILPSFGMFVEATHQKLLQQHPSGPAMDFPVPDPNALQSKLEMPPLPPLPPIQWRMGKYRNSPLTLEGAMIQSSFNPFLTPIAATSEEQANEGFPTLREGLTLPSNPFLSSPVNEDEKPQHGDEMSGGEIVQSSLNPFSSQLVTVDDENSKHGFQTFEQKMSNLNPFLPLPSPDDEKPQHSLALGGELGQPSLNPFTSPSPIEDVNSGHACISLQGEPTEPLKLLVAKQNIEDEMPQQSSLSPGRASLHLDSSVLPVTIPDEKPQHGSFSLEGEMTWPVSTSTQLPKVGDGKVNGKLMEPLNLSAAKPNIEDEMLQQNSLSPGRGASQNLDSSVLPMASDVEKLHNGSFSSEGEMMWPMSTSAQLPNLEDWRINGKPWRQPRPRNPLIEAVASHDKSMLRKVTERVRSLIEPKKDERDSLLEQIRTKSFNLKPAVTTKPSIQGPKTNLNVAAILEKANAIRQALAGSDEDDDDWSDS
The following text describes a protein:
Function:
Promotes slightly the tolerance to zinc (Zn) and to oxidizing chemicals (e.g. diamide).
Subcellular Localization:
Nucleus.
Sequence:
MDCVESYLSGDNSDESPVMHTWFSPSPSPSDSSSSPSSSASSSIGRNSDDGEKSSEDGGDDAGENEVESPYKGPLEMMESLEQVLPVRKGISKYYSGKSKSFTNLTAEAASALTSSSSMKDLAKPENPYSRRRRNLLCHQIWENNKTTPRGGISKKHVMSSSRSALTLAMAVAAGVMTGEGSSSGGDSSPGSSPTTSGSPPRQLHHHQHQMKKLPPLYPRSQGSFGNLTSSQSSLGFCAWRSFSVADFPRCFPATASGIGFNDS