lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Sequence:
MAKNKTIEERYQKKSQIEHILLRPDTYIGSVEMHTQLLWVWNKEKNRMVQKNITYVPGLYKIFDEIIVNAADVKAREKEKSENPMTCIKIEINKENKRISVYNDGEGIPVDIHKEMNIYVPHMIFGELLTSDNYDDAEDRITGGRNGFGAKLTNIFSKEFIVQCGDSSRKKEFKMTWSDNMSKFSEPHIKNYNGKDYVKVTFKPDLNKFGMTEMDDDIESLLFKRVYDLAGTCSVRVYLNGQRLAVKDFKSYVDLYLKDNSNDNKNNKGQNDNNNNNNNNNDENANQNNDNLDVSLSNEPADGTPTKNNNNNNNNNDEDEIVKIHEKQHRWEIVVSKSDGSQFQQVSFVNSICTTKGGSHVNYIVEQLLSSLSKKANAKNKGGMEIKSGHIRNHLWVFVNCLIVNPTFDSQTKETLTTKPVKFGSKCILSDKTINNVLKSPILSNILLWAQAKAQVELKKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLILTEGDSAKTSCLAGLSIVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFRIMGLDITDKNKDDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQKGSQEYSFFTIAEYEQWKENTNLLGWKIKYYKGLGTSTDREFKQYFSDIKNHKIMFLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKDFKGRIESNGKTGYETIGIINKIDNDTLEITELPIKKWTQDYKEFLEELLTDEKHQLILDYIDNSSHEDICFTIKMDPAKLQKAEEEGLEKVFKLKSTLTTTNMTLFDPNLKLQRYSTELDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKKKKKVLVEELYRKGYDPYKDINKIKKEEIFEQELLDAADNPEDNEEIIAGITVKDYDYLLSMPIFSLTLEKVEDLLTQLKEKERELEILRNITVETMWLKDIEKVEEAIEFQRNVELSNREESNKFKVARKQGPSSMKKKKKKKKLSSDEESEGGDISDSSEFLVNTLNIKKNTNKKTTTSSNNVNNSKKRLRKADDLNSNELDNTLSVSKTFDDNNNLTDNTPLINRLNDENNEFSSNNVDNKSTNKNSRKKKPKIADSTNDNNSELNSSIQINDNVNDDINITISPNKTINVNEFSSIKNKLLELENKKKPRLTLSEKVKMKNNDKKDTPNKGSAGKRTPSKKLKGTLIGDDSKSRQDSNFDSDASSKNNESYGDSDSSYNI
The following text describes a protein:
Function:
Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac-bound GDP by GTP.
Sequence:
MISGSGSRTPSNRLYLSPVRPTMQNKRRLLREYRSYDDLSEHYRMFGSQSLDSLQDRVDMNPSGCDGLSTDGLDFCSQSHSGLLREHNFKIKSYYYNVGNCVHCRKRIRFAMASLRCRACPLRCHIGCCRQLTVNCIPQPQIGTKRGCLSDYAPRVAPMVPALIVHCVTEIEARGLQQEGLYRVSSTREKCKRLRRKLLRGKSTPHLGNKDTHTLCCCVKDFLRQLVHPLIPIYHRRDFEEATRHEDRLAVEMAVYLAVLELHQAHRDTLAYLMLHWQKIAESPAVRMTVNNLAVIFAPTLFGDLDLTLENVVTWQRVLKVLLLMPAGFWSQFLEVHPLPTSLGSTYDFEDRYNHRHWDSSSNLGWSSVKTYFRSMVNLSSTHL
The following text describes a protein:
Function:
Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Sequence:
MTGGYFEIQNISGGYGSGRVVRDVSISIGRGEVVCLLGRNGVGKSTLAKLSCGFLRPMSGGVRLAGVEITGKRPSENLTQGLTYCPQERVVFDDLTVAENLSLMRTDRRLDEFEPYFRAFPRLSERRGQHAGTLSGGEKKLLSFVRGLSEGSAMAIIDEPTEGVQFENVVRMAELMLAQKEAGASFLVVEQNLTLVDRVADRIVIMDHGEIVLSAAASELDRRQILAHLTV
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTLPRQDKQRTTARLKIILLITSQLIGAGLFARGFFPAHKPPSGYGAPPHPTGKAPFDRLVFVLIDALRSDFMFGTDSRMNFTQSLVRDGKALPYTAIAQAPTVTLPRLKAMTTGMNPQFLDAVLNIADSTDQGALLEHSDSWLRQLLFSSQVASPTSPLVMQRKAIFYGDDTWLRLFPSSWFAEVDGVSSFYVTDTEIVDYNVTRHLDHALSEKQQQEWDIAILHYLGLDHVGHLGGSKSILMGPKQEQLDLAISRIFDGISKHDLRSKKKTLLLVAGDHGMTDAGNHGGSSKEELSTALLLASPSFNRVGSLSAQKDEPERVQQVDIVPTLAMLFGTGIPPASIGVAIESALELSFGDQKPHNVHLEAALRNHAVQLTTLLQQVFGGLSPVKAFLHLDDLGTENENLEAIISRLDVDRVRTILHRSQQYLLTRFSGYHLPSMVLGLIFLTIAVVGFIFEAFRGRGRRLNNREIMVVVLAAVQLASFGSTSFIEEEHEAWFFLGASSLSILAFLAPTTRKYHYLLGVVLIRVLRGWSHNGQKAGVDNSISNFVHGKPWLCHLLDPLGVYYLVSSQTRSGPGGGHYSSMGMLLIIGAGVFSLTPMDRPFLYLSRDIGVLQDRETRPRLLYGLLVSGLGLSFFRDMSKQSFRGALRIAILVLLRSLTKMENYPVLWLSFFAGDLCHFLTSNIKSIDSREGEVEQEGPILSTWIQLVFFKSTFFALGGSNSLATVDLSNAYNGLRSFSLPMVTLLTFLSNFSGSMIVGLGGLIQSSMRREETGREEIGCRQATTLVRSAYFSLHFLLISILSTHFSDHLFVFSVFSPAVLYAFVWFFGFHTLLSLLEILSSFL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MVKVYNLQRRTETLPTVRRTAPNAEELEYQSHLSRPAGAGDGEPTRRVETITFDMDNVSPPVANMFRRLMLTEVPVFAFDRILIEHNDGVVPDELLAHRIGLVPLAGPVSSMQYITDSASVGFDNLDPERVLLFELDVTAKRDVPTTSVYSGHLKWQPIAKQEELAARSEDDRVFLVHPDIVLTRLGPGQRLKLRAIAIKGIGAVHAKWTPVAACFYEMKQAKAGAEDSDGRASGRGRSRSGRGRVDANEEESNATRPRSASGNHSHEPHRETVNEVIAKRDTSSVRFTVESIGQLYAVDVFRQALILFAERIRDLAVRIRSTEPRMTGAAATAFTE
The following text describes a protein:
Function:
An RbcL-specific chaperone. Required for assembly of the RbcL8 core, acting downstream of the major chaperonin (GroEL-GroES). Acts on newly folded RbcL, has a transient dynamic interaction with RbcL and is eventually displaced by RbcS. The central cleft of the RbcX homodimer (RbcX2) binds the C-terminus of an RbcL monomer, stabilizing the C-terminus and probably preventing its reassociation with chaperonin GroEL-ES. At the same time the peripheral region of RbcX2 binds a second RbcL monomer, bridging the RbcL homodimers in the correct orientation. The RbcX2(2)-bound RbcL dimers then assemble into the RbcL8 core (RbcL8-(RbcX2)8). RbcS binding triggers the release of RbcX2 (By similarity). Required for optimal reconstitution of RuBisCO into its RbcL8S8 holoenzyme form upon expression of rbcL-rbcS subunits in E.coli, and probably also in situ. A frameshift mutation that replaces half the protein reduces accumulation of both RbcL and RbcS subunits and halves activity of RuBisCO in situ and in E.coli.
Subcellular Localization:
Carboxysome. Cytoplasm. Note=Most protein is cytoplasmic, but some is in the carboxysome. This cyanobacterium makes beta-type carboxysomes (Probable).
Domain:
The homodimer has 2 functional domains, a central cleft essential for production of soluble RbcL in which the RbcL peptide binds, and a polar surface which plays a role in correct RbcL subunit arrangement.
Sequence:
MEFKKVAKETAITLQSYLTYQAVRLISQQLSETNPGQAIWLGEFSKRHPIQESDLYLEAMMLENKELVLRILTVRENLAEGVLEFLPEMVLSQIKQSNGNHRRSLLERLTQVDSSSTDQTEPNPGESDTSEDSE
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Sequence:
MANEDDGKSFDIFDCESDFSRDCYASMHTPPSYSVPREDFLPPTSNWTVLSSLHQSAILGEQKAKMPLLIRVRGSRVLAGAAAFVAALMLLVGIFMNGVSVGSRDSVASVNDLNEYNFYTGTVAAMLAKPFEMALAVFVPVLSLVLSPRNSLQNGSVAWRALLFCSQGTLVALLTGVFSTLNVQQLDPLVVPVIVASDLSSSPTVSGSTSVANDVAFSLRQTDDTLLRTAILPVYVKATASLCQGRGGWPNIATTYAFFANDWLVDLLPEGCEASLLLNTRLGEEVSTTSGSGNGTISDWSSDNDLSAGFNASLSANLLLYAMFFSQTLLAWNGLSYLVNSSLAQFQDEISLWRGMDGVTESDFKVAASTMLRRTLDEQSSRLGLAFDTASTSFNASHTALSADIVFDAVTIEIPFDEHAVANNGSASTSASGSSRSLLHNFNSVTDCGETACLIPPPGRSFSATAMLGDTSYTQWNVEPQIQAFAACIFEGGTEFLTADYLHGASCTRRSTTSFLVYSFARRVVADDLTVDSSSSSSNSSRVVTVTNLQRTHTITLGRLSWRTKDLATSFNATCGVGDGGSSCSGISFPLTNGNSSASPARHLIVGESHLPIQSLGEFDGLYSRWTPLAMVTTPSDMQGDLLFQRNVRNQWQEDLDGLCSTGVDVFATQVEQNRWYMSYGLQESYTAALFLLFQNAVVREEQRSVDGSRTLDFAGSSARVTLEARIPLPSALISIVGCVMVLTGALCIAAAGRRKGGVIQRDVGVEDVAKVLLVNGRFPRLFLDCTLDDRSLLTRVDRGPPRKGKGAPARGEEESETSYRRRAFPVTLRMWDFQQCDSKRCTGRKLCRLGYIKSMKPGAHFRGLVLSPAGEHIVSPADRGLVEGTGVSAIDCSWARVQELPYKQLRSGVHRLLPFLVAANSVNYGRPHKLSCAEAIAATLYIVGLKQEAVQLMEEFSWGAEFLKINADCLEAYAACESSEQVVEAQNAYLAACQTENEQRLHRMMLPSLESDEEEEEEEEEEVQLDRFGNIIPREKPSEEEAGEEAGEPTKEQQLYKSKTYAYQSEEADSDEEVAKLTKNLHVATDSVKKTQEMREDLRTARGLDGEREAYAFSSMEDVHQQQVATVCLERTAVAVSGDAVLQLPESVFHQWAKDAETKPTEDDTEA
The following text describes a protein:
Function:
Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Sequence:
MPSVTQVRPLSYKRIISWYSGLVKAKPPEAPFKHVVQIGDPTLRTVSDVIPRDLIKLPEIKFLINRMKNVMKNHNSVGLSAPQVGVPLQLFLVECNAKHLNEYSPQEQKVKEMKVVPFKVVINPQIKITDYTKLTFVESCASVKGFHAEVPRYKSLKLEAFDEENQKFEMELTGWPARIVQHEVDHLNGKIYTDIMDRKSLACSCWQEINERGGKIELPYGPQ
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MHAWGDGALNAAGDWRYKGEGASNVVLDYRGSDSQLLGTVLRIRKAPLRENGGGCAPVLSDLERNLWKDWPAVASSSNEEELRHVYVRDVMRPLLGEDYVDSGVCVIVPVSRKFLEDVSQHIRANRPAWRAEEADLDFSSKNVLAVCDHTLFPGLANESDSPTLSIEIKPKWGYLPQSDAISTENHVKKVVSRFAMHQLLKFVQGKIRSSSSYCPLDLFSGTRDGIIKALNALFKSPQNNLRVFKDGNRIFTGSVDGAQDSTDSSASRDLLERSLVDFTDSVTGQRLDVLEKLIAEILHSSETLRKLLQTQQLDSLDIEGVIHLYYSFVGLHCPECGSDKTGCSIDSDVDKRSVLFASHHSMPADEQRRNLCKFLIAATAKDCSLMVTLKPLDDSIVASSVTRSIISCPTTGRSYVYKISFLDLDLKRLDKIPHYFRLDQSIVKFYAEHTT
The following text describes a protein:
Function:
Participates in the control of the reentry into the cell cycle following pheromone treatment. Involved in vacuolar protein sorting.
Miscellaneous:
MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MVELEKRRRPPPQLQHSPYVRDQSNSQGMTKTPETSPPKRPMGRARSNSRSSGSRSNVDIDQYTIPPGLDLLPTASSPPSVHQVSQQQQLSPILANKIRSPFENQSQDQNDNSIDPTPAGQVTIPVEAVSPPALDELSKFQNGSTETLFRTGSPRKKHTHIIILKSLNATFETKFLVVPFKPDGLKLGRPVTNSVNKNNSGSKRDLFSQQVRPDNGNFDSRVLSRNHACLSCDPTSGKIYIRDLKSSNGTFVNGVKIRQNDVELKVGDTVDLGTDIDSKFEHRKISAYVEEISVIPLMNTVSDPTNLVMKKQDHTNKNNGNSTNINGIKIDRGHHNQHIPIRSHLKENYTEAGVTSATTAQRAAFEAAMFGDINNSELDDDILGPETEVLSGIFINNSAGTSINLINMIKTLTTELSLEKQELEKLHSMQNFMQNYTINLDFINKHMIDMNEKHLLKLSTALQKTLSENNDALLKESEDQLKEIKQQNNKVKSACSLKEKQNHEKLQELESELRELNLQIEEERGKNLVLTQSNFNGGINNDNNAKVKQNDSREEKKDTEDTLISTEELGVVEGKRTRVSKGMLFGVVAISFGLVATAVKQLPQ
The following text describes a protein:
Function:
Catalyzes the attachment of tryptophan to tRNA(Trp).
Miscellaneous:
MISCELLANEOUS: Complex locus in which transcription results in the production of one large primary transcript that gives rise to two functionally distinct proteins, wars-2 and prx-10.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIFSGKFTSHLLNYGFKPNNLRLLSTSTHPTIYFTGIQPTGIPHLGNFFGSIEPWTELQNSVDKNILMMLSVVDQHAISLGPLPANELRQNTHQMTASLIACGVDPNRTLLFRQSDVPQIAQISWILGSLQTTSKLARLPQYKEKKERFKKGDIPVGLLTYPLLQAADVLTFKATTVPVGEDQSQHLNLLGGLAYAFNKTYETEIFPIPKQLTRESHARIRSLREPEKKMSKSSGGPRSRIEITDSRSTIIEKCQKAQSDNAGKVTYDKENRLAVSNLLDLYSAVTKTQTSEIDFSNWTTLDLKMNLAEAVDKRLAPIRQKFEELQNTGEVDKVLTENGEKAREIAEKNLEEIRRTIGFL
The following text describes a protein:
Function:
Hydrolase highly specific for thiamine triphosphate (ThTP).
Subcellular Localization:
Cytoplasm.
Sequence:
MAARAGTGRVRREPDRGRGQRLLPAFLAGVAWAPFPHLQVPREGDPRALRMAQGLIEVERKFVPGPGTEERLQELGGTLEHRVIFRDSYYDTPELSLMQADHWLRQREGSGWELKCPGAADVSGPHTEYVELTAEPAVVARLCEVLGAEILGAGHVAAVLGPLGLQEVASFVTKRSAWKLVLSGADEEEPSLRVDLDTADFGYAVGEVEALVHEEAEVPAALEKIHSLSSMLGVPAQESAPSKLIVYLQRFRPQDYQRLLKANSSGDKPPGTTDPDSSLG
The following text describes a protein:
Function:
Positive regulator essential for the expression of allD operon. Binds to the allD promoter (By similarity).
Sequence:
MFDPETLRTFISVAETGSFSKAAERLCKTTATISYRIKLLEENTGVGLFFRTTRSVSLTAAGSHLLSQAKDWLAWLDSMPDELRQVNDGVERQVNIVVNNLLYSPQAVASLLSWLNARYPFTQFHFSRQIYMGVWDSLLYEGFSLAIGVTGTEPLANTFMLDPLGSVQWRFVMSADHPLAHVSGPLTEAQLRRFPAINIEDSARTLTKRVAWRLPGQKEIIVPDMETKIAAHLAGVGIGFVPQPLCQTLIDKNELVSCTIPTMRPPSPLSLAWHKFGGGKAVEDIVKLFTQRQPEIAGFLSIFNTVRC
The following text describes a protein:
Function:
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Subcellular Localization:
Cell junction. Cell membrane; Single-pass type I membrane protein.
Sequence:
MFCPLKLILLPVLLDYSLGLNDLNVSPPELTVHVGDSALMGCVFQSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQSTEVKHVTKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGSIMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQLVIIVGIVCATILLLPVLILIVKKTCGNKSSVNSTVLVKNTKKTNPEIKEKPCHFERCEGEKHIYSPIIVREVIEEEEPSEKSEATYMTMHPVWPSLRSDRNNSLEKKSGGGMPKTQQAF
The following text describes a protein:
Function:
Upon expression in E.coli has a weak triacylglycerol synthase function, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Also functions weakly as a wax synthase, as it incorporates palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MSPIDALFLSAESREHPLHVGALQLFEPPAGAGRGFVRETYQAMLQCREIAPLFRKRPTSLHGALINLGWSTDADVDLGYHARRSALPAPGRVRELLELTSRLHSNLLDRHRPLWETHVIEGLRDGRFAIYSKMHHALVDGVSGLTLMRQPMTTDPIEGKLRTAWSPATQHTAIKRRRGRLQQLGGMLGSVAGLAPSTLRLARSALIEQQLTLPFGAPHTMLNVAVGGARRCAAQSWPLDRVKAVKDAAGVSLNDVVLAMCAGALREYLDDNDALPDTPLVAMVPVSLRTDRDSVGGNMVGAVLCNLATHLDDPADRLNAIHASMRGNKNVLSQLPRAQALAVSLLLLSPAALNTLPGLAKATPPPFNVCISNVPGAREPLYFNGARMVGNYPMSLVLDGQALNITLTSTADSLDFGVVGCRRSVPHVQRVLSHLETSLKELERAVGL
The following text describes a protein:
Function:
Involved in starvation response and aggregation stage of the life cycle. May be involved in fruiting body morphogenesis and spore formation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MIAKVFKSITPESYILLVNAGLISAYGVRIIFQSVKNDEGKVDEKAHIGIGHFFKKRGAQLVDGKNLTDILKEKKKKKKKKKKINISNKLIIFKISRQLYSKLKLK
The following text describes a protein:
Function:
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Vacuole and punctate structures.
Sequence:
MGSSMPPPHVRAWYSYAFAAEVFSACALAIFLPITLEQMAREVGYYAPELTETCVINDSSSDVTGRLCKARILGVWIDTASFSMYVKSIAVACQAICIISIGPLADIAYWRKRLLLTFAYSGSLSGILFLLFPPLPYAWTPIMAAILNIVGNATYSTSIVCSNAFLPGLAKEDVDVQKAWEEATSEGLQDGLRDVHEDTDEENTGSVSREDEATHLLPDRLIPAVCAISTQDLALSDPLAKLIEPSNAKKHYESRLSLTTSRLSSTGTAIGFFSGVSVLTLLLIPVTALGGSTFSMRLAIGLSGVWWALFTVPTCIGLPGGAPGHGSDFSASQVKKAWVKIGKMVAPKQIHQLPNLYIFLLAWIFLSDGFHTTTYAAILYASSVLSMSAPKIILVGILVQLAAVVSSVLVPRVQRRLSTTSSKPVTNYKVLLAGVVAAAFIPVYTCAGLVLPFGGLRSEEEMYVLAVWFGLVFGPFLSYSRAVYAELIPPGHESTFFSLFAFTDKSASFIGPAAVGLISDLTGNIRYGFLFLLVMLVVPIPVLGRVAVERGRREAVEWAERSRKEMSDERV
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MDEEIKHEIRKMALQNAFEHGGQTQDKIILGKILGTKPEFRTKVKEISGEISEIVASVNQLSPEEQQKEMEEKFPEALAPKEKIEEREGLPELKDAIQGKVVTRFPPEPNGYPHIGHAKAAIINSEYAKMYGGKFILRMDDTNPEAERMEYHAAIKVGLEWLGIEFDQVKSTSDDMEVFYEKGIELINSGKAYVCTCKREDISQNRRERKACKCSMEDVGKNNKNWEKMQNKFKPGEAIVRFRGDMKADNAVMRDPVLLRIIDEKHYTVGDKYRIWPSYDFAVAIEDSIDGVTHAFRSKEFELRKELIDAILDALGMRKPQQGFFSRLEFKGMPISKRIIKPLIEEGKVSWYDDPRLPTLEALRRRGIKPEAIRKFIMSLGLTKANTLAPFDALEAFNRKFVDADSMRLFMVKNAKKLKIKNLQSTIVEVPNHPINDLGKRKIEITEDFYISGDDSEAIKEQSTIRLLGLGNVKITKIGNELEGEFERDGDSSNILKIQWVPQKTAHEIKMIIPKILFNDEEFNEDSLEELDVYTEPQYLQLKEGEEIQFVRFGYCRKDSQNQAIFTHK
The following text describes a protein:
Function:
[CLE43p]: Extracellular signal peptide that regulates cell fate (By similarity). Promotes pollen tube growth prolongation in a SKM1 and SKM2-dependent manner, especially under relatively high temperature (at 30 degrees Celsius), thus conferring tolerance against high temperature probably through the maintenance of mitochondrial activity.
Subcellular Localization:
[CLE43p]: Secreted, extracellular space.
Sequence:
MGCRDILLTFSVALLLISLFQIWLFREGRQVPELSDDQLGKDRNTLMTSKNKNKNEDVQRLFQRYFKGRSFGLNNTNSRFEDSNRRIPSSPDRLHN
The following text describes a protein:
Function:
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). It recognizes the wobble base of tRNA(Met), thus distinguishing between tRNA(Met) and the structurally similar tRNA(Ile2). Could use an RNA helicase motor driven by ATP hydrolysis to deliver the wobble base of tRNA(Met) to the acetyltransferase domain of TmcA (Probable); Also functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription. Can specifically catalyze the 2-hydroxyisobutyrylation (Khib) of the DNA-binding protein H-NS. Hydroxyisobutyrylation of H-NS decreases its DNA-binding activity, promotes the expression of acid-resistance genes and enhances bacterial survival under extreme acid stress.
Miscellaneous:
MISCELLANEOUS: 467 endogenous Khib candidate sites significantly regulated by TmcA were identified in E.coli using a quantitative proteomics approach.
Subcellular Localization:
Cytoplasm.
Sequence:
MAELTALHTLTAQMKREGIRRLLVLSGEEGWCFEHTLKLRDALPGDWLWISPRPDAENHCSPSALQTLLGREFRHAVFDARHGFDAAAFAALSGTLKAGSWLVLLLPVWEEWENQPDADSLRWSDCPDPIATPHFVQHLKRVLTADNEAILWRQNQPFSLAHFTPRTDWYPATGAPQPEQQQLLKQLMTMPPGVAAVTAARGRGKSALAGQLISRIAGRAIVTAPAKASTDVLAQFAGEKFRFIAPDALLASDEQADWLVVDEAAAIPAPLLHQLVSRFPRTLLTTTVQGYEGTGRGFLLKFCARFPHLHRFELQQPIRWAQGCPLEKMVSEALVFDDENFTHTPQGNIVISAFEQTLWQSDPETPLKVYQLLSGAHYRTSPLDLRRMMDAPGQHFLQAAGENEIAGALWLVDEGGLSQQLSQAVWAGFRRPRGNLVAQSLAAHGNNPLAATLRGRRVSRIAVHPARQREGTGRQLIAGALQYTQDLDYLSVSFGYTGELWRFWQRCGFVLVRMGNHREASSGCYTAMALLPMSDAGKQLAEREHYRLRRDAQALAQWNGETLPVDPLNDAVLSDDDWLELAGFAFAHRPLLTSLGCLLRLLQTSELALPALRGRLQKNASDAQLCTTLKLSGRKMLLVRQREEAAQALFALNDVRTERLRDRITQWQLFH
The following text describes a protein:
Function:
Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAGPTVFEDVAGEFALDGVGQLFEGKKFWVAQRVPSRVRLLDDIKANGGEVVLLEKRADYKIADHFRKDCPPGTISYEFVTKSIQDGRLRDPEDHPAGPPEGDARAPGDLHRPAKGSRTPYTPEEDAICCKWVRDCVARGGSASGNEIYKQLEEKYSRHPWQSWRDRYLKQLRNRPPSAFNIPDNAPPSPPSDHPSEQPARATPVPNPANQATEKVTGHGTARDTKSAVPPNYTLEQLAATFSSEDWEELYANVDVINAIDGDDKSNYEKAWKKWAEAQDNQTAEQWQQYYEKVVRPQWMRDPESKREQVKQKVDKKHEAQSQSQTADQQQQEDLHEDASTGATSTGAESNKISKEAPVAAGNERFQGEASKLPSENKMMSSSTAQYESPKYIKAMYQNVLKRARGDDTEEQQPGQQIPREQSPPPKRQRSLSPITRTTSTVPVQAGTSKQPVEIFSSDGSSSDEEGMQLNNQIMEDVKQPQHDRHVLAQGEVEEDIERVEPEDLVDIEQSPAPPEVLGERSEDELPSNTPTPRPPRHRTNNFDTQAILSSPSQDARISKLPRPIDFTQAMETQDEQRSSSLAPHLDSDNSTTQSLQEFRRSLNGEEISQLSYPALQPLPRAPSFSPTPFNSSDDSDDPDPPLAADELDDFFAAQNAVGLSDAFVARALKRTRCRPGLAEIVLDAWKDGKPLPWQRGIWSLEDDEAAESGDGVELAQLERKHTLDGWGGITERLRFLEGYRSR
The following text describes a protein:
Function:
Hydrolyzes both the R- and the S-enantiomers of mandelamide, and phenylacetamide. Has lower activity on 3-phenylpropionaide and lactamide. Does not hydrolyze benzamide. Hydrolyzes esters and amides with little steric bulk. Preferentially hydrolyzes aromatic substrates.
Sequence:
MRHPVDMPEKVGTDAKRLFAQPEHLWELTLTEASALVRHRRITSRQLVEAWLSRIADFSELNAFISVDAAAALKQADSYDHYLEAGGDPLPLGGVPIAVKDNIQVVGFANTAGTPALSKFFPTCNARVIEPLLKAGAIVVGKTNMHELAFGTSGYNTAYHIPGVIGVRNAFDHSCIAGGSSSGSGTAVGALLIPAALGTDTGGSVRQPGAVNGCVGFRPTVGRYPVDGITPISPTRDTPGPIARSVEDIVLLDSIITGALPAEVPAAESIRLGVVDQLWADLSEPVRKLTEDALRKLEQQGVQIVRVSMSEIFEMSHAVSMPLALHECRSALTEYLSANETGVSFDELVAGISSPDVRTIFEDYILPGRLGELEGQSVDLEQAYATAMKDARPKLIQSFEFLFKEHQLDAIIHPTTPDLAIKSNPAATSFEAFARMIRNADPASNAGMPGISLPAGLSQQEGLPVGIEIEGLPGSDARLLSIANFIESILGRGPTPTRSGVESKISM
The following text describes a protein:
Function:
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis (By similarity). Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex.
Subcellular Localization:
Golgi apparatus membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Note=Recruited to the midbody during cytokinesis.
Sequence:
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFQRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKNKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSKAEAMKPPELKEKLEESEKLIKELTVTWEEKLRKTEAIAQERQRQLESMGISLETSGIKVGDDKCYLVNLNADPALNELLVYYLKDHTRVGADTSQDIQLFGIGIQPEHCEIDIAADGDITLTPKENARSCVNGTLVCNTTQLWHGDRILWGNNHFFRINLPKRKRRDWLKDFERETSSAEHDLDAASEASSEPDYNYEFAQMEVIMKTLNSNDPVQNVVQVLEKQYLEEKRTALEEQRLMYERELEQLRQQLSPERQPPSSASDRLAYSSQTAQQKVTQWAEERDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQIPAANLSANRKRGAIVSEPAIQARRKGKGTQVWTIEKLENKLIDMRDLYQEWKENVPEAKRLYGKRGDPFYEAQENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVTRITGTIPERMAEDDSSENSSESGSLEVVDSSGEVIHRVKKLTCRVIIKEATGLPISLSNFVFCQYTFWDQCESTVAAPVVDPDVPSPQSKDAQYTVTFSHCKDYVVTVTEEFLEFISDGALAIEVWGHRCAGNGSPIWEVDSLHAKTRTLHDRWNEVTRRIEVWISILELNELGDYAAVELHQAKDVNTGGVFQLRQGHSRRVQVTVKPVQHSGTLPLMVEAILSVSIGCVTARSTKLQRGLDSYQEEDLNCVRERWSDALIKRREYLDEQIKKVSNKKEKTEDDMEREARLVEQWVGLTEERNAVLVPAPGSGIPGAPADWVPPPGMETHIPVLFLDLNADDLSANEQLVGPHASGVNSILPKEHGSQFFYLPIIKHSDDEVSATASWDSSVHDSLHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLRKRIAANIYNKQSFTQSLKRRISLINICYSCGVTYEIVSNIPKATEEIEDRETLALLAARSENEGTLDGETYIEKYTRGVLQVENILSLERLRQAVTVKEALSTKARHIRRSLSTPNVHNVSSSRPDLSGFDEDDKGWPENQLDVSDYSSSYQDVACYGTLPRDSPRRSKEGCPSENPHALTVSPFKAFSPQPPKFFKPLMPVKEEHKKRLALEARPLLSQEDSEEEENELEALSRKLMLTQPYVPVEFADFSVYNASLENREWSSSKADLTDSRALEKAVSRSPTTSSLTSGYFSHSASNATLSDMAVPSSDSSDQLAVSTKEVECAEPPGPSLAPDVRRASNQELTEVGRGSGKDETIAVPLEENSALPKGTPSPQSIPEESSRMPCRTASCSELDVGPSKDGHQAREFCPGEVTIEHTTNILEDHSFTEFMGVSDGKDFDGLADCSVGEPSRRRALTNETDHKGIPERPPDADRLHPKIENDQEATATR
The following text describes a protein:
Function:
Involved in the biosynthesis of the stress protectant 2-O-alpha-D-mannosyl glycerate (MG) which is produced in response to growth at supraoptimal temperature and salinity, and protects several enzymes against inactivation by temperature, freeze-drying and osmotic stress. Catalyzes the condensation of alpha-GDP-D-mannose (GDP-Man) with D-glycerate to produce alpha-mannosyl-D-glycerate. It is specific for GDP-Man, but it can also use alpha-GDP-D-glucose (GDP-Glc), beta-GDP-D-fructose, alpha-UDP-D-mannose and alpha-UDP-D-glucose as sugar donors. It is specific for D-glycerate, but it can also use D-lactate and glycolate as sugar acceptors. This reaction occurs with a net retention of anomeric configuration; the newly formed glycosidic linkage has the same alpha configuration as the sugar donor.
Miscellaneous:
MISCELLANEOUS: The biosynthesis of mannosylglycerate in R.marinus can proceed via an other alternative pathway, in which a mannosyl-3-phosphoglycerate synthase catalyzes the conversion of GDP mannose and D-3-phosphoglycerate into a phosphorylated intermediate, which is subsequently converted to mannosylglycerate by the action of a mannosyl-3-phosphoglycerate phosphatase. A noticeable feature distinguishing the two enzymatic systems involved in the synthesis of MG is their dependence on salt; while the mannosylglycerate synthase reaction is salt-independent, addition of NaCl or KCl is required to achieve full activity of the mannosyl-3-phosphoglycerate synthase/phosphatase system.
Sequence:
MSLVVFPFKHEHPEVLLHNVRVAAAHPRVHEVLCIGYERDQTYEAVERAAPEISRATGTPVSVRLQERLGTLRPGKGDGMNTALRYFLEETQWERIHFYDADITSFGPDWITKAEEAADFGYGLVRHYFPRASTDAMITWMITRTGFALLWPHTELSWIEQPLGGELLMRREVAAMLYEDERVRRRSDWGIDTLYTFVTVQQGVSIYECYIPEGKAHRLYGGLDDLRTMLVECFAAIQSLQHEVVGQPAIHRQEHPHRVPVHIAERVGYDVEATLHRLMQHWTPRQVELLELFTTPVREGLRTCQRRPAFNFMDEMAWAATYHVLLEHFQPGDPDWEELLFKLWTTRVLNYTMTVALRGYDYAQQYLYRMLGRYRYQAALENGRGHPVPPRAALSTA