lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MDFFVRNGEEPYMQFSNFKLRSYFPHEIDKLSVLKITQTKTFDEVGHPIAGGLYDPILGPDNTFDMCMTCNQYERHCPGHMGHIQLAVPVFNPLLFQFTYNLLKGSCVHCHRLTCKGDGVNARMLLAQLRCFELGVEHVAFDLESILRDKIANADLFGDDDSKTFNDVDACIAQLANKPLSELTAFKSMPTKNSVQLKKDIITEFLRSHLFKRLQKCPLCKNRNGVLRNDGARSILIDFTSGARGGGKSKKAIIIIGDNGYNEESSTDEDEEKKGGGGAEVTGDVVDLDEGSLEMQMKNVRTGECDKLAWRGAEVREHFRMLFKNDGKLLLKLFPMLVDELNGEDMICPLDGLFLERILVPPKKFRPIRMFKGAQYEDPQTLNLRKVLEATETISAISLIMKGDTSAQLKELIANRVRGKTINAQMHDAYLQLQLRANAIFDQDLNKGDRDSIAGIKQILEKKQGLFRMHMMGKRVNFACRSVITPDPYLDIDEIGIPDIFAKKLTFTEPVNAFNVNEMKGLLRQGPHQHPGANFFVEPSGKKTMLGDKPEEKKRRMQMAKTLNAATTENLRQTPKVLRHMKNGDMIMMNRQPSLHKPSILGHRARVLTGQRALRMNYAPCKAYNADFDGDEMNGHLVQSHIAQTEVREIANVGSNFLVPKDATPLLGLIQDHVVSGVLLSVRDRFLNKEDFMHLVLASFAQYSKRIEIPPPTILYPKRLWTGKQVITTIVKNCIPDGKPLINLDGKAKTPLSCWIVPGFDAPQFDMSESHVVFRQGELLVGVLDKAHFGATQFGLAHCAFELYGHRCGVQLLSCFSRLFTTYLQFHGFTLGVADILVVKDADGKRKEAVMESRTIGNQVVKTAFGLPDTATPAEIKRTLAATYCNPRGQGTDVKMLDFGMKQGIAKYNDAITKSCVPTGLLRLFPQNALQLMIQSGAKGSAVNAIQISGCLGQIELEGKRMAVTIAGRTLPSFRCFDPSPRAGGYIDQRFLTGMNPQELFFHTMAGREGLIDTAVKTSRSGYLQRCIIKHLEGIRVHYDSTVRDHDGSVIQFRYGEDGMDTTKATFLNKKTMPFLEDNLEAVTLASKPEGVTDADFGIKETEKRYKKIVKWKKKAEKSGKSGTKKSYFSAFTNFSAEHIGMEKKRILAMWFELSLEEREQYARGIPKKCPEAVDERFNPTCKLGALPEKMLDEIEGFCTRRVKKVDDEEPPKEVLKRTLYWKGMRSLADPGENVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMTASKSIATPSASIAVIAGTSRDRIDSIKRELDRVYLKQLLKNFSLEEKITLTQNQSCRRYHLRIDILAAEKRELGARHLKRSQIMEEIEKRFILRVAQAIKKKYHEITDYQQMSHRTMRQGNMAAGIETGGTKNRGLQGPDNGDSSDEEADGGREADAAEARLHRRHRDEGADYEGEDEERVEVREEEEPMDSDSEDVKKEGLDGEDQTTEPLLVNSSRIQSVQRLSENISSYTYDVKSNKWCEVVFELPLRNKTKMDVSSIVEKEVELFIVHQTPGIERCVETTEQKNGKEMTILQTQGVNLAAFFKHADVLDVNSVYSNDLNLILENYGVEACSKAITTEMNNVFAVYGIEVSKRHLSLTADYMTFTGQIQPFNRGAMSSSSSPLQKMTFETTMAFLREALLHGEEDNVNSPSARLVMGALPRGGTGSFDLLLDTKMQSEREEHEAARARKRNAKQKF
The following text describes a protein:
Function:
Required for normal Golgi function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MDFSKFLADDFDVKDWINAAFRAGPKDGAAGKADGHAATLVMKLQLFIQEVNHAVEETSLQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLAAESLQEADKWSTLSADIEETFKTQDIAVISAKLTGMQNSLMMLVDTPDYSEKCVHLEALKNRLEALASPQIVAAFTSQSVDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLATWQELCQSDLPLDRQLTGLYDALLGAWHTQTQWATQVFKNPHEVVTVLLIQTLGALVPSLPMCLSAAVERAGPELELTRLLEFYDTTAHFAKGLEMALLPHLQDHNLVKVVELVDAVYGPYKPFQLKYGDMEENNLLIQISAVPLEHGEVIDCVQELSHSVHKLFGLASAAVDRCAKFTNGLGTCGLLTALKSLFAKYVSHFTNALQSIRKKCKLDDIPPNSLFQEDWTAFQNSVRIIATCGELLRQCGDFEQQLANRILSTAGKYLSDSYSPRSLAGFQDSILTDKKSPAKNPWQEYNYLQKDNPAEYASLMEILYTLKEKGSSNHNLLSASRTALTRLNQQAHQLAFDSVFLRIKQQLLLVSRMDSWNTAGIGETLTDDLPAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDSALELALHAGKLPFPPEQGDELPELDNMADNWLGSIARATMQTYCDVILQIPEVTPHSTKQLATDIDYLINVMDALGLQPSRTLQNIAALLKAKPEEYRQVSKGLPRRLAATVATMRGVNY
The following text describes a protein:
Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MGDRTAPNGHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYNTREHKQKFYLGHNDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSILKDIHTHGIACLAFDLEGQCLVSVGLDSKNTICVWDWRRGKVLAAAPGHTDRIFDISWDLYQPSKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDEVTYSGALNGDIYVWKGISLVRTVQGAHGSGIFSMNACEEGFATGGRDGCVRLWDLNFKPITVIDLRETDQGYKVTRGENCRGLSVRSVCWRGDHILVGTQDSEIFEVVVHERNKPFLIMQGHCEGELWALAVHPTKPLAMTGSDDRSVRIWSLIDHALIARCNMEEPIRCAAVSTDGIHLALGMKDGSFTVLRVRDMTEVVHVKDRKEAIHELKYSPDGAHLAVGSNDNAVDIYGVVQRYKKVGECIGSTSFITHMDWSADSKYLQTNDGSGKRLFFRMPGGKEVTNKEELKLVQWSTWTCVLGPEVNGIWPKYSDINDINSVDANFNSHVLVTADDYGLVKLFRYPCLKKGAKFKKYLGHSAHITNVRWSHDYQWVITIGGADHSVFQWKFVPERKAKDALHIAPQETLVDSNSEESDSDQSDVPEMDSEIEQETQLTYRRQVYKEDLPQLKEQCKDKHRGTSTKKRERAPGSTVRLHFVHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNRQQNTQRFYLGHDDDILCLAIHPLKDYVATGQVGRDSSIHIWDTEVLKPLSVLKGYHQYGVCGVDFSADGKRLASVGLDDNHTLVLWDWRKGEKLSAVRGSKDKIFVVKINPYMPEKLITAGVKHMKFWHKAGGGLIGRKGHVGKMETMMCAVYGWTEEMVFSGTCTGDLCIWRDMYLIKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDTFERCLKTYAIKRSVLAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPHLPLCATVSDDRTLRIWDLSPSHCMLAVRKLRKGGRCCCFSPDGKALAVGLNDGSFIIVNADTLEDLVSFHHRRDVLSEIRFSPGAGKYLAVASCDSFIDIYNVMSSKRVGVCKGAVSYITHLDWDKRGKLLQVNSGAKEQLFFEAPRGKKQTIPASEVEKIDWCSWTCVLGPSCEGIWPVVSDVTDVTAACLTSDKKVLVTGDDFGYVKLFRYPVKGKFAKFKRYVAHSTHVTNVRWTHDDALLVTAGGGDTSLMIWTHEPEGHRESRQGDSEESDIESEDDGGYDSDVTRENEINYTIKALSTNFRPMSGIKPHLQQKEPTVDERQGVVSLLLGRGSRPPVSRALPQPEKLQTNNVGKKKRPIEDLVLELVFGYRGNDCRNNVHYLNEGADIIYHTASVGIVLSLTTACQSFYMEHTDDILCLTINQHPKFPNVVATGQVGDSADMSATSPSIHVWDAMNKQTLSVLRCFHTRGVCSVSFSATGKLLLSAGLDPEHTVTIWKWQEGARVASRAGHTQRIFVAEFRPDSDTQFVSVGIKHVRFWTLAGRALLSKKGVLSSIEEARMQTMLSVAFGANNLTFTGTISGDVCVWKEHILVRIVAKAHTGPVFTMYTTLRDGLIVTGGKERPSKEGGALKLWDQELKRCRAFRLETGQIIDCVRSVCRGKGKILVGTRNAEIIEVGEKNAVCNILVNGHMDGPIWGLGTHPTRDVFLSAAEDGTVRLWDIPEKKMLNKVNLGHAARTVSYSPEGDMVAIGMKNGEFIILLVTSLKIWGKKRDRRSAIQDIRFSPDSRYLAVGSSESAVDFYDLTLGPALNRVNCCRDIPSFVMQMDFSADSNFIQLSTGAYKRLVYEVPSGKQVTEQAVIDRLTWATWTSVLGDEVVGIWSRNTDKADVTCACVSHSGLNIVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSAHVTNIRFACGDRYVISAGGDDRSLFVWRCVHAPH
The following text describes a protein:
Function:
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Sequence:
MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFVKVRSAKSAAIHHIIAEAGS
The following text describes a protein:
Function:
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by Tmem8a modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Released from the cell membrane by GPI cleavage.
Sequence:
MGYFSSSVVLLVAISSAFEFGPVAGRDLAIRDNSIWDQKEPAVRDRSFQFVPSVGIQNSKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASGTPCQTPSVTTTFMLAGACLFLDMKV
The following text describes a protein:
Function:
Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MRRLETLESILERLRMSIKKNGLKNSKQREEVVSVLYRSGTHLSPEEITHSIRQKDKNTSISSVYRILNFLEKENFICVLETSKSGRRYEIAAKEHHDHIICLHCGKIIEFADPEIEHRQNEVVKKYQAKLISHDMKMFVWCKECQESDD
The following text describes a protein:
Function:
Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation.
Sequence:
MSVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSAGEEEDEEEETMDSETAKMACPRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPTDTKESSEKDALTQYPRYKKYQLACTKNVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIKSEPPSEENEEESITLCLSGDEPDAKDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRSVASPSCLRSLFSITKSVELSGLPSTSQQHFARSPACPFDKGITQGDLKTDYTPFTGNYGQPHVGQKEVSNFTMGSPLRGPGLEALCKQEGELDRRSVIFSSSACDQVSTSVHSYSGVSSLDKDLSEPVPKGLWVGAGQSLPSSQAYSHGGLMADHLPGRMRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNQLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLRPMDLPTASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPPWAPSNTSENCTSGRRLEGTDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDYT
The following text describes a protein:
Function:
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Sequence:
MPQQPKNHVEQVCLARRLESSVTVNLLGAAVTSLTMNGVERLFLSKSTVLNNKTPIRSGIPVLLSEDPEHAFFRTSQWILVEQNKYPNGDVNASFVLEDNENTRKQWDQKFKATLKISLKKKEITFDYIIENKDSKPFTCAPMLQNHFLVDDVTNTSVLGLQDADSSDEVNGFF
The following text describes a protein:
Function:
Proposed to be involved in endosomal maturation implicating in part vps-33.2. May play a role in epithelial polarization through stabilization of apical membrane protein content. May play a role in transcriptional regulation (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. Essential for vesicular trafficking during spermatogenesis; required during spermiogenesis or sperm activation for the morphogenesis of specialized Golgi-derived fibrous body-membranous organelle (FB-MO) complexes. Required for the processing of internalized proteins in oocytes and coelomocytes.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle. Early endosome. Recycling endosome. Late endosome. Note=Localizes in both residual bodies and budding spermatids.
Sequence:
MALRRKFTFELPEDSYWNESDSNSSGLFDDLQSKQLQARAAVDNLFGGDETPKPYVRPQNPTPTPTNVPLQIDGRAAAVSDKANIRITDTSPRASGKIVDDFLNMKFAENVNVAPVIQTAPSVVSEASASSLPSEAQRLDLDYNRLRQEHRKLKDQHEVLRHERFQPLTIEASIKRMLQGHTVTLDYYRSLRDKTQLLKQAVATYDNNTIFKIVIFLERTLKENIFCKIMDGQKSACRVYTRHLQITGEWDKMNKFLRSIGQYQHASVIEFEATRKYKRNPDKRVPLLRTMLHGSFSIPEMKFEARQMEALMRNYEIQLQMEKMDAGDKGEHFRKFPKTSSLIGLPALSSLYYSAMYHYDDSPTSAASLPSVQTLIRFNDRLATQTIVSALTRLSRWPDIDKLLQPKTITMTFSAAKSVFKGKKSTSKWGVSINNHNLLTIVKRSHPSPPTDFIYRILKGESDAQERLRLALLFDVPEMVIECLTQKGDRLSLASYAKSLKTNSVESFKAVAALNNPSIKWK
The following text describes a protein:
Function:
Component of the SCF(scon-2) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
Sequence:
MSSVLMSKTVTPFLREHIPSIYAPIGKPGNQETARAENPNSKYCYRHHPDSKCRRAADKAKMVMIQSELDKLTSADQQAVTHVWSLFSAAPARHRDLMLQGILSQLCFPQLSFVSREVNEALKIDFISALPVELAQKVLCYLDTVSLTKAAQVSQRWRTLADSDAVWVRMCEQHVNRKCTKCGWGLPLLERKKLRNYTRQRQLAKGGPQGRVTELADSHDSQDRSVNQHGKRPAAEAEEEDPIKKRQCMAAAEASKAVTQPKTRSWKAVYRDRWQVSYNWKNSRYKLSVLKGHENGVTCLQLDDNILATGSYDTTIKIWNIETEECIRTLVGHTAGIRALQFDDSKLISGSLDHTIKVWNWHTGECLSTFAAHTDSVISVHFDGHLLASGSSDKTVKIFDFNSKETYCLKGHSDWVNSTHVDIKSRTVFSASDDTTIKLWDLDTRQVIRTYEGHVGHVQQVLILPPEYEPDEEVLNGASQDNQDAMSVSSGGSGSPSMSHAQIERAGSPGSHSSSHNLLPSSLPSGDEDVRHLYGSAFVADESRPLPPRYFMTGGLDSTMRLWDSATGRCLRTLFGHLEGVWSLAGDTIRVISGANDGMVKTWEPRSGKCDATYTGHCGPVTCVGLSDSLMASGSEDGTIRLHSFKPCRQ
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MIKVEMTPISPLQPPIPRSIDNRLQWGNLKGDSVSLAISTLAEKNQGPLLLITPDVHSANYLHRSLPFFSSADTPILHFPDWETLPYDYFSPHEDIISERLLTLYRLPRLSSGIIISALPTLLQRLPPADHLEKNTFILSVGEKFSLQENRERLISAGYRSVQQVMEHGEYAQRGSIIDIYPMGSPLPYRIELFDDEVTSIRSFDPESQRSVEKIESVRLLPAREYPLTKEAITHFRQSWRAKFLGNPQEAPIYQQISEGEAAAGIEYYLPLFFETTQTFFSYLPKNTTVILFEKLETVAHQFWQEVEHRYEQLRHDLTRPLCPPSELFLSFEQLRIEIKNHTQIKISDAPIIEKTGQVNFATENFPPLLIDHKASQPFARLKNFLHEITAIQGGRVLFCAETDGRRETLLEFLKEIDTTPQAVKNWRTFLAENTRVGLTIAPLDKGVLLSSPPLAIISESQLFGEQIRQRRLEKERKIDPNLLIRNLTELHIGDPVVHIQHGVGRYLGLQTIKTSDQEAEYLTLQYADNDKIYVPVSSLYLISRYAGADASHAPLQKLGSKQWEKIKEKTQKHIRDVAAELLDIYSRRQAATGFTFSIPEKEYSLFRQAFPFEETPDQSAAINDVIVDMSSKRSMDRLICGDVGFGKTEVAMQAAFIAVQNNKQVAVLVPTTLLAEQHFYNFQDRFADWPVRIAAISRLRTQKQRQQITQELAEGKIDIIIGTHKLLSKDIRFKDLGLLIVDEEHRFGVTQKERIKSLRAHVDILTLTATPIPRTLNMSLSGIRDLSLITTPPAKRLSVKTFVHDYSPVLIREAILRENLRGGQVYFLHNDVATLAATAEKLRTIIPEARLAIAHGQMRERDLERVMSDFYHQKYNLLVCTTIIESGIDIPTANTIIINRADRFGLAQLHQLRGRVGRSHHQAYAYLLIPDQEALTADAEKRLSAISQLDDLGVGFNLATHDLEIRGAGELLGVEQSGQIHDIGFSLYLELLEEAVSALKAGREPQFEKPLHAVSEIDLGITTLLPEDYVPDVNARLILYKRLANCKNKREIQALKEELIDRFGPLPPAAQHLLQSAELRLIANELGIQKINIGSKYGYFHFDKKPAIDLTKLIKLVQTQPQRYQLQGDESLRFILSNPTPQSKLETIYELIKNLK
The following text describes a protein:
Function:
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway.
Subcellular Localization:
Cytoplasm, cytosol. Cell membrane. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex.
Sequence:
MFTSEIGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVTSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLRFTLQFLPELMWCYLAVSASRDVHSSGCIEALLLGVYNLEIVDKHGHSKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYRGVSSRIPISSGFMVQMLTGVYFAIYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGAMKSSKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGDTELTGQEELMDITEVDEGFYSRAASSTSQSGLSNSSHNCSNKTSVGKNQRRSGGSKAGAKERETAGESCRDHFARKQTQRAQSENLELLSLKRLTLTSSQSLPKPSSQGLAKTAATVFSKSFEQVSGAPVPRSPSPAIGCVAGADANRFSACSLQEEKLIYVSERTELAVKCQAGQQGPPSISVTLSAE
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLPGFPSRELTVQVQVEHEPDILLDVRDTLDIGYHADTFNYMAPPSPASPFETLHSCTHPRSPVHGSAEPGTPVEKLVEQALKERQNFYARRKAKIEKTKEDNRKVLLYTKSLQLLIRCRSKEKGHIAAFKMSRNDWEAVASIIDLTKHFTMKDNRGNMINIYKAGTSKSITSRTDLARMHQVLLKLNQSFTEGKS
The following text describes a protein:
Function:
Transcription factor that acts as activator.
Subcellular Localization:
Nucleus.
Sequence:
MRNRMAPENPQPDPFINRNYSNMKVIPPQDPASPSFTLLSKLECSGTVSAYCSLNLPGSTDPPTSASRVAATTAIRRRHKERTSFTHQQYEELEALFSQTMFPDRNLQEKLALRLDLPESTVKVWFRNRRFKLKKQQQQQSAKQRNQILPSKKNVPTSPRTSPSPYAFSPVISDFYSSLPSQPLDPSNWAWNSTFTESSTSDFQMQDTQWERLVASVPALYSDAYDIFQIIELYNLPDENEISSSSFHCLYQYLSPTKYQVGGQGSSLSIFAGPAVGLSPAQTWPNMTSQAFEAYSLTDSLEFQKTSNMVDLGFL
The following text describes a protein:
Function:
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein.
Sequence:
MLPTTFLAVILACWSIFHLLHNFVTGNEYLGPICDRFLKKRSIFVTPFQVRYFTKKLNRYLAHFGRWRKLKVWFDAGILFAALAMLSSTILLIHTLVKSFLDLNIFTTTPAVPSSQTPGFSTNILSPYNITTMYMQVLTVIVPGVNLPLNDLSYLLTAILLSGILHELGHAVAATREGIEVNGFGIFLFVIYPGAYVDLNSTDLNRANARKQLRVYCAGVWHNFILCLIACVLIFSLPFMLAPFYSQGGEGVIVTYQAQNSPLQGSSGIMVGDVVQHIGNCHVQESKTWFKCVNESRTLPQMGSCIKWNELEKLTLKSSAGTLSDGHPDCCGVNPPPTHLCYHYKVSQKKQMFACLPGRTMMSFKDCTNNVDCGRHDQAVGVEGICAFPLLGDTTTRFMRLKILRYPNLPAQHVLYLGEPADLVRFLTISEYRPRWWWLPLRLPAVLLKFLQYMFSMSGALAVLNIVPCYALDGQWAFKSFLDFFYGRHPDLDNFKERVSTVVLCCGTLLVTLNVIFGFLNVFIK
The following text describes a protein:
Function:
Transcription factor that promotes photomorphogenesis in light. Acts downstream of the light receptor network and directly affects transcription of light-induced genes. Specifically involved in the blue light specific pathway, suggesting that it participates in transmission of cryptochromes (CRY1 and CRY2) signals to downstream responses. In darkness, its degradation prevents the activation of light-induced genes.
Subcellular Localization:
Nucleus.
Sequence:
MSLQRPNGNSSSSSSHKKHKTEESDEELLMVPDMEAAGSTCVLSSSADDGVNNPELDQTQNGVSTAKRRRGRNPVDKEYRSLKRLLRNRVSAQQARERKKVYVSDLESRANELQNNNDQLEEKISTLTNENTMLRKMLINTRPKTDDNH
The following text describes a protein:
Function:
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MPELPALLLSIYFRFLLVTVVTMPPSSLSQTPVLSSVRMAAILDDSSVCGRGERLALALARENINSVMENPARARVEVDIFELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKEIPHVKIGPEETPRLPYLRFASVTLYPSNEDLSLAIGSILRSFSYPSASLVCAKAECLLRLEELIRRFLISRETLSIRMLDDNLDPTPLLKEIRDDKIATIIIDANASISYLILKKASELGMTSAFYKYILTTMDFPLLWLDDIVDEQSNIVGFSMFNTTHPFYLEFIRSLNLSWREGCDINPYPGPALSSALLFDAVHVVVSAVQELNRSQEIGVKPLSCTSPQIWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLHILEKHRGGHKEIGIWYSNNTLLMNSTSLDINVSETLANKSLIITTILENPYVMRKINYQEFEGNEQYEGFCVDMLRELSDILKFTYRIKLVDDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITSEREKVIDFSKPFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYNPHPCLRERRDLLENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVVNSKYAFLLESTMNEYHRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKRRWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFVWSTRRSAETDEVRPLSCDRQYHSHTTVSVCQEMLTEFRNAVSCKKSSRLRRRRPLSSSLALRHPTRITLGAPRPLRLVREMRLSNGKLYSGTGPLTGGSGPGGGPTDMGPGPQRLLEDPLGANSTPAVALGPPAVTVPLPRGCTHVRICQECRRIQSLRTTSCTRIPPSSAPLPRLAPPPPHSSSNTDSEGGGGLSPCRIGHSPPAKGCSLPPPQSSNNTDLMGEQK
The following text describes a protein:
Function:
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MPHWITHPSELTERLQLRPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMTDALKDWLIAPDIVKVMHSASEDLVTFKCACGVLPRPLFDTQIAAALAGVGGGMGYQKLVQEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIHDALTAKLTAQDRLGWLAEDGERLLGTVEHDDGDRWPHVSLRTAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILDNELASQLARFPPADLDALMRQFDKFPKAPRKLANAVWEALNTPLPDEDHAPLAQASTDGNKATLKRLQDAVAQRSRELELPDGILASRRHLETLIEQRSWPAALGQWRRDALEADLLPLLDAATP
The following text describes a protein:
Function:
May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels (By similarity).
Sequence:
MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRHVLGERRQRAPN
The following text describes a protein:
Function:
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Sequence:
MQIIEGKLQLQGNERVAILTSRFNHIITDRLQEGAMDCFKRHGGDEDLLDIVLVPGAYELPFILDKLLESEKYDGVCVLGAIIRGGTPHFDYVSAEATKGIAHAMLKYSMPVSFGVLTTDNIEQAIERAGSKAGNKGFEAMSTLIELLSLCQTLKG
The following text describes a protein:
Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1 (By similarity). PAF1C is required for transcription of Hox and Wnt target genes (By similarity). PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL (By similarity). PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription (By similarity). PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors (By similarity). In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription (By similarity). Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3) (By similarity). Required for Hox gene transcription (By similarity). Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (By similarity). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (By similarity). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTNQYSILFKQEQAHDDAIWSVAWETNKKENIETVVTGSLDDLVKVWKWRDERLELQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQMKSIDAGPVDAWTLAFSPDSQYLATGTHMGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCIHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHVYDCPI
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MANRSYYDQKMSTLRDLGTSWESCRRVLSTVTLAQRPLRLAELCVLSGLPQETQAKDIVALCDSFLTINEKDDSVDVDLPTKDYLINEARDEIYPSGVTGAHLSLFSRSLEAMSSTLRRNIYSLHHPGVSVDEDMLLIPEPDPLATIRYSCVHWISHFCDAYESDACHKHQIDPDNAKSVDNFLRSTTLYWLEVLSLIQETASALRSMWRLVLLLRRKSSDSDLLDLVRDSYRFFLQNISAIKCAPLQVYASALVFSPADSLIRKLFGKEEPNWIETKPDVANHWSPCLQALEGHEAAVLSVSYSHDSRLLASASDDRTVKIWDTETGSLQHTLEGHSDLVRSVIFSHDSRLLASASDSTVKIWDTGTGSLQHTLEGHRDWVRSVIFSHDSQLLASASDDSTVKIWDTGTGSLQHTLEGHRDWVRSVIFSHDSQLLASASDDSTVKIWDTGTGSLQHTLEGHRDWVRSVIFSHDSRLLASASDDRTVRIWDTEKGSHKHTLEGHSSLVTSVSFSHDSRLLASASNDQTVRIWDIEARSLQHTFDLDATIEAMRFDKATSLWIQVTVKASIRSAMGMA
The following text describes a protein:
Function:
Transferred from male to female during mating and may affect egglaying and behavior after mating.
Subcellular Localization:
Secreted.
Sequence:
MHGTHFLILLLLCGVLGSNGVTPDIKNVAKAERNMHNMLRCLKKNEPIVKSRILTLPPNCNQYVSAVVETWKPEGV