lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MADQPQTTTTTQSNRIINQSANVSDLDISLHPLPILNISDHFTRTRLQAERQDIDIFGALIGTQIGKKIEIVNCFELLTDSDGKVNDGFLKTRREQFQQVFPTLDLLGWYTNGPEPREKDLAILNQVSECVDLSSPILLLYDLLPTPSSSSGSTTAAKELPVQIYEFTQATTGADGEGFVKCTFDVQTSEAERIAVDCVAKPDVGSNESGLVSNLITQRNAIQMLHNKLGSIVDYLAQLMADLEPENPTATATKIDHGLLREISSLVASLPKPDENASFKKEYMTEFNDALLTSYLSSQSKVLTETNQLIDRYLYLNARDNNLKFGSSSASHSVGKSLKMPK
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (By similarity). This cyanobacterium does not encode bioA (which catalyzes the formation of the precursor for this reaction in the cannonical pathway), instead it encodes bioU, which replaces bioA and also performs the first half of the cannonical BioD reaction. Thus in this organism BioD has a different substrate (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAGVLVSGTDTGAGKTILCAALAAWWLAHRRTPAAILKPVQCGPGDREYYRTVFGDALSVLNPLYFEAPLAPPLAAAREGQTVDIGLLWKSYCEAAAGHALVLVEGVGGLGCPLGWDYTVADLARDWRLPVLLVAPLRLGVVGQLVAHTGFARAQNLDLSALVLSEIEPVSAEQRAQWADVQLIENLCHLPVLGVLSHLEAATDRAALAAAGSGLWLEAAGTLFTAERG
The following text describes a protein:
Function:
Binds to 23S rRNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MDGIKYAVFIDKSIRLLGKNQYTSNVESGSTRTEIKHWVELFFGVKVIAMNSHRLPGKGRRMGQQIL
The following text describes a protein:
Function:
Probable transcription factor that binds to acetylated histone H3.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The NET domain could serve as an interface to localize different proteins or complexes to chromatin.
Sequence:
MASGPIAGGGVSKTKHKWSDSGNKSQKRSKPTVANSNSLGLEDNHQMMKISLSSISKLEVRNLKRKLQAELEEVRSLIKRLEPQGNNFAPVPNKKLKTANGGKKGGVHGAAADKGTVQILKSCNNLLTKLMKHKSGWIFNTPVDVVTLGLHDYHNIIKEPMDLGTVKTRLSKSLYKSPLEFAEDVRLTFNNAMLYNPVGHDVYHMAEILLNLFEEKWVPLETQYELLIRKQQPVRDIDFHAPVSTNTHNVEALPLPAPTPSLSPPPPPKVVENRTLERAESMTNPVKPAVLPVVPEKLVEEASANRDLTFDEKRQLSEDLQDLPYDKLEAVVQIIKKRTPELSQQDDEIELDIDSLDLETLWELFRFVTEYKESLSKKKEEQGLDSERDAESFHNSVHESNTLVTGLESSKVTELGHVASTVRQEVNVGGSSSSNSSSSGSGSGSSGSDSDSSGHESDTGN
The following text describes a protein:
Function:
Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLISSQNKIAHPAVAAERQKKIEAMKERLKMKKELEMKGHSFVEFLSINQHITEDQLSSMLQLLFVQQYDDVIEERTISSFCGYPLCPADLIEVPKKKYHIYQKTSTVYNIEERKKFCSNKCFLYSKHLRKQISAEPLLERSKNATKFSFLKDHSKFNISDGLGDVILQPPGRSLANEIKKLNSAHDDDVDDDDDDLDDDDDVRNDNNFNRDDYDGFNYDDDDNEENNKKIPPKPNVVQKRKIEARQTVILQADWELPPMASSKTSEAGEATTISSSSSSAAASSSASSIATTTSASVTTTNECDEHLLKKVHNYMLEWRSESTYLFNEEMETDDADEVSTNKSDGQVLVLPATDHKDIMLIRRGVVLEKLEPVLKKYSEILKVNLSQVMTSVRSLVLTFNFSSTNIIMKPLEWMVAGLILLHVVSKKDEGLRRKLNQTNMHNTFMKKFNITVRQFDEIATEILSKPSEYQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGDMSNSDFYSKNQRNEANHAADFGCDLMELRSLMELRGSEAVVKIKECYGDTDGLCKRLKTSPTEGLPGTVADLEKRREIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYRPPGGETEGCGGTAAGAEDEGEAEAGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRGSQVIQIPVAEMVVGDIAQVKYGDLLPTDGIFIQGNDLKIDESSLTGESDQVRKSIDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGASEVEDEKKDKKVGSTHPPSHPPAATDGAAGANAIDNANASLVNGKMQDGNVESIQNKAKQQDGAAAMEMQPLKSAEGGDGDDKDKKKSNPHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFAIDTFVVNKRQWLPECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAFVGDAHYKEIPDPDGLPAKTLDVLVHAIAINSAYTSKVLPAEKDGGLPRQVGNKTECGLLGFVLDLKRDYQVVRNKIPEEKLYKVYTFNSVRKSMSTVVKLDDGSFRMYSKGASEIILKKCSRILNEAGEPRIFRPRDRDEMVKSVIEPMACDGLRTICIAYRDFPMSPEPEWDNENDIVTDLTCLAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCIDGKEFNRRIHNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTQVEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAVYQLTLIFTLLFAGETMFNIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFLGFGELVWGQVISSVPTSRLKFLRGAGNLTQKEENQEEELNEDAEEIDHAERELRRGQILWFRGLNRIQTQIEVVNTFKSGASFQGALRRQSSTTSQNQDVTNISSPSHVSLSNALSSPTSTSAAAAGHPRREGIP
The following text describes a protein:
Function:
Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Subcellular Localization:
Cell junction, tight junction. Endomembrane system.
Sequence:
MKVTVCFGKTGIVVPCKDGKMSVRELIQQAAQRFIKAKEKEPGYWVKVHHLEYQDGGILDPDDIVADVVEDKDKIIAVFDEQEASEIKNRNEDSVNVIDRTSPDPLEAELSAQLSAFQPLKGEIDVTSSALKIGTPLLVRRSSDPTVGPAVDFHPSSSQSADQNVNDASQGLSRVLPPDEQTDQNTGLQKPLYKIREITRKVEISGSGGPLGIHVVPFYSSFSGRALGLYIRGIEESSRSKREGLFQENECIVKINNVELIDRSFAQAQDIFRQAMKQQNVLVETVLPEKRELYEKSVISSLFVLDDDIDEVPDIKPPPPPVHVNRSIKMPEQVNGIDPTGTKIQQPPLSPNLISSESKFSSPSLSPLGFGNKKNGKKLRIDLTKGAEGLGFTVVTRDSTVHGPGPIFVKNILPKGAAVKDGRLLSGDRILEVNGKDIAGKTQEELVAMLRSTKLGESVSLVVARQDETFLPRELKGETENLVFPPDNTAQMTFEIPLNDSGSAGLGISLKGNKSRETGADLGIFIKSIIHGGAAFKDGRLRVNDQLVAVNGESLLGKSNRDAMETLRRSMSMEGNIRGMIQLVILRRLDWQTEERSETFQKNTIENLAVSEQNGVQEKLKVADESNIGSLREHQSGSPGKDFGPRLGLKKSSSLESLQTAFAEVKKNELPFYRPRPHMVRGRGCNESFRAAIDKSYDGPEGEEEDALSDLSSHSGRESPNSELTPLGNQEMEDTDKSKKEKKKKDVKKEKAKAKGKEKKKKDDAEEHEKKAKKKGFGVLGRLIKKKEEKGNQKQGTLKEEENEVEKMKEERERINIKHQELREQQAKNLLGYNWSHDMEDDDMDPNYAKVNHFQEAPLNHNAHRPYSPPTTLPPSYPRETQVLSSEREDLYAKINKKQQAPDKSDSGRSTSGTADRIQQLRMEYHQAKQEGFLMHEDDDELGRHLEYEQTWIPIRSPEASRLRYDGMERQYASLPRHGPFQPEFMPGPSTGYNEREPPYYYDVAHITQSPKGAYSQTQAHHKASYRIPPYQPPQAKGPIRQDVPPSPPQNYRLPGYNAVVRPGQEEYQYDPRQKNPLTAAV
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDHQSRGGSWNLVPSASQTLIQDEQQRFHSLPSQFHLLPIIENLADAIEGGTRDQHSDALVSELSTQFDKCQQLLNSISASVNVKAMTVEGQKRKLEEYERQLNQRRELIAEYRRSVEEFTKSDCNR
The following text describes a protein:
Function:
Component of sequence-specific heterotrimeric transcription factor (nfya-1-NF-Y and nfya-2-NF-Y) complexes which specifically recognize a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types. In association with the components in the NF-Y complexes, represses the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues. May act to repress txb-2 expression in conjunction with tbx-2 itself, which has an autoregulatory role (Probable). In association with the components in the nfya-1-NF-Y complex, negatively regulates the expression of the homeobox protein egl-5 to spatially restrict its expression in tissues such as the head. May regulate egl-5 expression in association with the mes-2-mes-3-mes-6 complex.
Subcellular Localization:
Nucleus. Cytoplasm. Perikaryon. Note=Localizes to the cytoplasm of secretory cells and cell bodies of the small ganglia surrounding the pharynx.
Sequence:
MSQFPEVLDNNLLHAENNETAEYIQNDGTNQSEVFMEHPYTPNMHPINMPSIVEGAVHPYNNLIHHNDAIPPAKYASMRQMTEDFWREKKQKMTEISEEDMLNKSKNMSVPMARVKKIMRIDDDVRNFMIASDAPIFMAQAAEFFIEEMTAMGWQYVSEARRRILQKADIASAVQKSDQFDFLIDFLPPKTVPTTSTNGPGHMSEDSFQDPNMHSDFHQRTSNSSVNRSHHN
The following text describes a protein:
Function:
Transcription factor involved in the regulation of root hair development, possibly through auxin signaling. Its endoplasmic reticulum membrane localization is not compatible with its transcription factor activity in the nucleus. May be cleaved to target the nucleus.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus. Note=Its endoplasmic reticulum membrane localization is not compatible with its transcription factor activity in the nucleus. May be cleaved to target the nucleus. A truncated form of MAMYB (amino acids 84 to 309) lacking the 2 transmembrane domains is localized to the nucleus.
Sequence:
MDFFDEDRPRFVFQSRPSSSHTAEEEEEARIPNKLFISISVSISLIILSLSFFYFESEPAKSLLLWLSLSFLVGPFAPSSLTGGKIRVGYGQILEPEQIHDESSTDNERESRRKSVNKRSKGSTKSDNPPENASAVTEVSRKVVIPQSKESGSVNETKDWTAEEIEILKKQLIKHPAGKPGRWETVASAFGGRYKTENVIKKAKEIGEKKIYESDDYAQFLKNRKASDPRLVDENEENSGAGGDAEGTKEIWSNGEDIALLNALKAFPKEAAMRWEKIAAAVPGKSKAACMKRVTELKKGFRSSKTPAN
The following text describes a protein:
Function:
Involved in formation and maintenance of cell shape.
Sequence:
MHRKIIDGKNKNIWRIILFLLFLTIILWSAGYLESIAFRIQYSFNRFFYNLQRTFDDIKSYITMTESLQKEIAELQTEILSLYKENQNLKLILENIKKREDYIPWLKDLADKNIEIIYADIVGRDPIKWNLELKVNKGYLDKVKVGMPVLYKDQVVGRVVRTEKHYSIVRTIYDPNFVLGVTVLETKDQGILRGGYDHMEMAYLFSDHGIKEGNTIITSGTEDNIPYGLKIGYIADLKEKAIFSFSNMKILPFEDISNIEGVAICVKF
The following text describes a protein:
Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Sequence:
MTIKLYQYQTCPFCTKTRCFLLAHGIPFENIEVHPIFKKEMKFSKYKKVPLVTVEKNGEVLELRDSSLIISILSSYIINEGMNITELLKRYPTTTVVGEDGKSKQETLNKHWLISDEADLATVENDARKEEAEWRFWADDYLVHLISPNVYRTYREAYQAFDYHVKQGRFNGTWEGVVAKYLGSIAMWGIAKRLKTKYKLDENVRLDLYKACNKWTEAIGKGRTFMGGSKPNLADVSVFGVLSVMENLDSFHDVLTHTNIKKWYYKTKQAIEDHGGQTLNLRTTT
The following text describes a protein:
Function:
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
Sequence:
MLKTCLLYCSIYPENYGFNMRHLVMRWVAQGFIYEEAASEGYFKELACRGLMLPDGQGTYQMNPMMRNFLRCKSCEDDFFTCSSGITSESACPVHLLCIDEYPVDDGGVRVIDLDWSQVRTLVVFKGAGSLPFEKLEHVRVLDLQDNYVDPESEEAFWDDHVKDICGLLRMRHLFGLGGVGVSKIPLEIGRLQYLETLEVVGTSIRELPVEIGALKQLKTLDMSINRRLTELPMEIGGLQHLETLRIRETNITKPPWEIIGMLKKLKNLDVSVNEWIRELPREIRNLHHLETLDLSRNRGLTNIPGEIGKLQHLKTLNVSSASITRLPSEIGRLKSLETLDLSYNKRLTELPREIGNMQNLKHLLLCGTMVGKIPREIGGLKKLKILILDGTIIALVWEVGQFSELEGVPECIRQAWKNGDLVSELAGETMSYNKGDLTVGTKHMHIPPWIKQYFNNLLNLDIRICKLEEPDLKILREMPNLCLLRLRFVVVPRKPISISGKGFPSLMVLVVDSRVPRLTFQEGAMPKVQYISFEFRFYGGLPNEDRLSIKHLRSLGWLEFTCNKWYRGAGSSPFISAMVDVARKEAQEHPNQISFRVSGCEDENFPANKSAQVGEASSSGTGEIPRVLHCQK
The following text describes a protein:
Function:
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the antitumor fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts. The simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from anthranilic acid (Ant), tryptophan (Trp), and alanine (Ala). The trimodular NRPS fmqA is responsible for FQF formation. Modules 1, 2 and 3 of fmqA are predicted to activate and load Ant, Trp and Ala, respectively, providing for the assembly of an Ant-Trp-Ala-S-enzyme intermediate that would undergo double cyclization for chain release and generation of the tricyclic 6-6-6 product fumiquinazoline F. The presence of an E domain predicted for module 2 of fmqA is consistent with epimerization of L-Trp to D-Trp during assembly to generate the R-stereocenter at C14 of FQF. The FAD-dependent monooxygenase fmqB and the monomodular NRPS fmqC then maturate FQF to FQA. FmqB oxidizes the 2',3'-double bond of the indole side chain of FQF, and fmqC activates L-Ala as the adenylate, installs it as the pantetheinyl thioester on its carrier protein domain, and acylates the oxidized indole for subsequent intramolecular cyclization to create the 6-5-5-imidazolindolone of FQA. The FAD-linked oxidoreductase fmqD introduces a third layer of scaffold complexity by converting FQA to the spirohemiaminal FQC, presumably by catalyzing the formation of a transient imine within the pyrazinone ring. FQC subsequently converts nonenzymatically to the known cyclic aminal FQD.
Subcellular Localization:
Cytoplasm.
Sequence:
MKLPAAAGDAIVIGPNAVRLIKSWGEQLCEEIEPHLSNATHAEMLDHHDRFIVRHELAGRGKGWFTNRGRLISILYEHARKLGIDIRLGSRVTKYWEEDGRAGVIVNDRERLAADCVICADGVHSAARAWLTGQVDTQQHSGWANFRAHMTTEQLAKDPEASWVLQGTREKDRVYVWFGDGINLAIMTMKRGQELAWALMHTDKFNAHESWAGGRASIDDALATLSPWPGRLRPSSVIRHTLPEKLVDHALIYRPPLDTWVSAGGRVMLIGDAAHPYFPVVGQGGSQAIEDGVVVATALELAGKENVPLALRIRATLTEENNVLMEAGNSRYPRATVIQLGSSTLQEHLFWPDWEAVAKDPSVFAFPNPEWILGHDCREYTHQVFDTVVRAVRGEGEYIPRNIPADGAYRVEDTYSPE
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKEKIHISIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLAFTLGVKQMICCCNKMDATTPKYSKGRYEEIVKEVSSYLKKVGYNPDKIPFVPISGFEGDNMIERSTNLDWYKGPTLLEALDQINEPKRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFGPTGLTTEVKSVEMHHEALTEALPGDNVGFNVKNVAVKDIKRGYVASNSKDDPAKGAASFTSQVIIMNHPGQIGNGYAPVLDCHTSHIAVKFQELLTKIDRRSGKELEKEPKFLKNGDAGMVKMMPTKPMVVETFAEYPPLGRFAVRDMRQTVAVGVIKSVDKKDPTGAKVTKAAAKKGVK
The following text describes a protein:
Function:
Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRQGGGGGERMVSVLFLLLIHLALCQAKCVMTECDGEEDSNHPPCKTNKSTYLPITVTRSLNPTYMARFEKYCSYLVQEEDKAQVCCTELQLKGMTDRISNAATILGSCPSCFDNFAKLWCQFTCSPDQSKFMKVMETTGPKNVVVKMEFKVNRDFVEGLYESCRHTWFANGLALRLMSLGGKVSFENFYGFMGTKNLAQSIPINTEFQFSRMKNAMNIPTTPCHKSAGPKVPACGAIDCPTNAHQLVDISKVEHLGTKVFHPHFPDFEWLLKICGCLALTVLLVFILKYSCHRRSAPNGEDGCYVDLGKGNLEVQFEGLCARYANAVIKHPLIFVSLGLIVAAACCSGNFKFHSLTHSVDQVSAADGETRRNEKKFIHSFGPNHRIEQIFINLPPTTKSMFNMPLFEEMFQLVGNIQNLTACYGNSSVKLDDICYKPIGKNHGCAIMSPTNYFQNKWTNFENAGPPTIDDEIFDDQHWEHLKYCIRNPLTVSTYSEMSCFGEFSGPIDPILVFGGSNESIKGAEMYYTARTIMITVLIRGPEDQAIAWETAFLNMMSRYEMKHANFTFMTETSVAEEIHTAVETDKIVSVIACAAVLIWVITMLGINHWPESSILSALVHHKLLISISAVMISVISVWCSIGMFSLFGVHATDNAIVVLFFVITCLGINRIFVIIRTFQANGHCYGLPNISYREMNHRISNVMRRSIPIVLTNSLICSTCLFLAGGVLPYVSVSMPAVEVFARHAGLAILMDTAFYLLVMLPLFQYDARREMSGKCEIWPWYELSNESKINLCMEAVDGNLRSPVDWFKLAIAPLLLKKICRIWIATFFFVSLIIACYCTLCLEFGFNQVMAFSETSYLTKHFQNMNENLNIGPPLWFVVEGDVKWHDPKMQNKFCTLAGCDDNSMGNKIRSLAYAENYKGNYLHGDVNIWLDSYLQFMHPRGSCCKMDGKQFCDPSNATHCSSCSSSSVASLTTTEYEFYRNLHHFLETPPSIQCAHGGMALAKPAINLTRNGKIQSAYFSTFFKKLNLSDSIQLYDAWRFAKYLADDIERELEIPGVKVYVYSTFFPYYEQYLTLSTTVYTLVVLVLFVAFVTISLFLRVNLAGSLVTVFVLLSSYLHLMEWMYLLGITVNVVSVINMAMSLGIAVEFFGQMLHGFYNSKKPKREERAFAALVSNGSTTLSGIFPAIMITAGCLSFADSRVLITYFCNQLVGIGLVCAVHGVVYMPTLLAIFGSDFYQNVSSEEESTDEAELQDTPPSTTSSTSSTSETSV
The following text describes a protein:
Function:
Involved in 20S proteasome assembly.
Sequence:
MSHLTGAERSRDSWWPHGRQESMATLVLPLVSAGNVPQLCADVLLHSTPGEFRFVRELDGQWLHPFVGPLDYVEGQESLLYRDAPGKRVTTPLELFYCEQRQLYLVQQRSPVVQGYENEFCKEVLLPLLEELAPQRVVVLDSVGEFETEVPVHTETMESRFSVATCNVTSISDVAKEFAEGLQLDEQNDLSVNSTLFSFRQGSFQRGISTEQFIFKFSYHLLHSPLARSADFAELSYVSIFIHEGDNNEDALLLCTELPTFVEVFPRLETLRTPISWKGVYGSRRIPDGYDEGLYI
The following text describes a protein:
Function:
[Isoform 2]: May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.
Miscellaneous:
MISCELLANEOUS: [Isoform 10]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm.
Sequence:
MSEQGGLTPTILEEGQTEPESAPENGILKSESLDEEEKLELQRRLAAQNQERRKSKSGAGKGKLTRSLAVCEESSARSGGESHQDQESIHLQLSSFPSLQEEDKSRKDDSEREKEKDKNREKLSERPKIRMLSKDCSQEYTDSTGIDLHGFLINTLKNNSRDRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSVIINKTSSTRIPEQRFCEHLKDEKSEESQKRFILKRDNSSIDKEDNQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDSVCSQESLFLDNSRLQEDMHICNETYKKRQLFRAHRDSSGRTSGSRQSSSETELRWPDHQRAWSSTDSDSSNRNLKPTMTKTASFGGITVLTRGDSTSSTRSAGKLSKTGSESSSSAGSSGSLSRTHPQSTALTSSVAAGSPGCMAYSENGMGGQVPPSSTSYILLPLESATGIPPGSILLNPHTGQPFVNPDGTPAIYNPPGSQQTLRGTVGGQPQQPPQQQPSPQPQQQVQASQPQMAGPLVTQREELAAQFSQLSMSRQSSGDTPEPPSGTVYPASLLPQTAQPQSYVITSAGQQLSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQMSVYYYPSGQYPTSTSQQYRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQQGFQGMMGVQQSAHSQGVMSSQQGAPVHGVMVSYPTMSSYQVPMTQGSQAVPQQTYQPPIMLPSQAGQGSLPATGMPVYCNVTPPNPQNNLRLMGPHCPSSTVPVMSASCRTNCGNVSNAGWQVKF
The following text describes a protein:
Function:
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
Sequence:
MLKNDTVFTKDISCTAITGKDAWNRPTPQPITISLSFSTDFQKASELDNLKCSINYAVITRNVTEFMKSNEHLNFKSLGNIAQAISDIGLDQSRGGGSIVDVTIKSLKSEIRAESVEYKINRNTLGQPVPLDIFQVNKLRLLTIIGVFTFERLQKQIVDVDLQFKIAPNSNLYFHQIIADIVSYVESSNFKTVEALVSKIGQLTFQKYDGVAEVVATVTKPNAFSHVEGVGVSSTMVKDNFKDMEPVKFENTIAQTNRAFNLPVENEKTEDYTGYHTAFIAFGSNTGNQVENITNSFELLQKYGITIEATSSLYISKPMYYLDQPDFFNGVIKVNFQNISPFQLLKILKDIEYKHLERKKDFDNGPRSIDLDIILYDDLQLNTENLIIPHKSMLERTFVLQPLCEVLPPDYIHPISAESLHSHLQQLINDKPQETVQESSDLLQFIPVSRLPVKDNILKFDQINHKSPTLIMGILNMTPDSFSDGGKHFGKELDNIVKQAEKLVSEGATIIDIGGVSTRPGSVEPTEEEELERVIPLIRAIRQSSNPDLSKVLISVDTYRSNVAEQSLLVGADIINDISMGKYDEKIFDVAAKYGCPYIMNHTRGSPKTMSKLTNYESNTNDDIIEYIIDPKLGHQELDLSPEIKNLLNGISRELSLQMFKAMAKGVKKWQIILDPGIGFAKNLNQNLAVIRNASFFKKYSIQINERVDDVTIKHKYLSFNGACVLVGTSRKKFLGTLTGNDVPSDRVFGTGATVSACIEQNTDIVRVHDVKEMKDVVCISDAIYKNV
The following text describes a protein:
Function:
Molecular chaperone. Has ATPase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTSDSAVHTQPFQAEVSELLHLMVHSVYSETDIFLRELVSNASDACDKLRYEAIESPALLGEGDALKIRIIPNKTAGTLTIADNGIGMERQELIDHLGTIARSGTKAFVSKLKEAKDGLGLIGQFGVGFYSAFMVADKIIVVSRRAGESDVWSWTSSGGSGFEIARASEEDAARVTRGTEIVLHLKDDAKKYLETYEIERIVGAYSDNILFPIELVPEEGEPRQINSASALWQRSKSELSAEDYKKAYQQIASAFDDPAMTLHYRAEGRYSYAVLLFAPSTKPFDLFEPSRKGRVRLYVRRVFITDDADLLPGYLRFIRGVVDSEDLPLNISREMLQNNPQLVQIRKAVATRVVSELEGLAEKDAENFAKIWDAFGAVLKEGIYEDFERREKLLALSRFTTTTGEKRSLKQVVADFKPNQTEIYYLVGDSIERLKSNPRLEAATARGIEVLLLSDPVDAFWTSMPTEFEGKPLKSLSQGDLNLDLIPRVDATDEAKKDEPEADEAATIAVIKAALGERVSDVKASTRLTSSASCLVADSQGPSRELERILSQQNRGMRAKPVLEINLRHPMVGAITKAQAGSKAVDDLSLLLLEQAQILDGELPEDPAAFAARLNRLVLQGLGG
The following text describes a protein:
Function:
Required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. Involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. Regulated by transcription factor esg. The longer hdc protein is completely functional and the shorter protein carries some function.
Miscellaneous:
MISCELLANEOUS: Readthrough of the terminator UAA occurs between codons for Ala-650 and His-652. Readthrough is not always suppressed as the shorter protein is more abundant.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPRRNSNISSSGNSTQQQHQQQLQQQHQTQQHQLLQFYAENVNSSGVLMAPMQGTGGVGGVGGGGMVHCCLPSGDCRKLDTLIHLNELSLADCIRVLCNNENCSAGQYMHRECFEWWEASVLQALKANGRARSWSERQRLQHLWTKKGYELVQKACSCKCGRGQLRKDLDWVPPSSQGVIYLNGSGNRPTLANGSLSEDDDKKKAKKKRNRNNNNNNGGGGGGGAGVNGNTKTPLSNNNGNSYAGLTPNPNVGVIGSGLPHNNGNTASNGSSGNNGSSGVLQTSALATFSNILNTNNVLGLDLRARAGSLSSSGAGSGSTSPSDSQSSGEISVSPVQQLLPQQQQQQQQSLLIQPLGPAFGSNLLQNGLGLSKNLLIAPQQQQQQQLQQQQQQQNNLPALANISNFKPLASYEQQQLVQQQKNKEVELYSDRVRSTSGCNGIFSRRLDFSSFNLLPKTRLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKYEGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQQRLSFYSDYSHGVTCPYCNTQDTHFVKPLTFCYAKTTATRLPTLAXHEAPLESPVGTGATTTQVPNAQGSPTASGCSSNTIASKQPPKQPLYNAAIDYSAPLQQQINPDLIGAHPHAQQHQQQVRQQQQQQQQQQPQQQQQQQQQQTQQQQSQQQQQQQQQQHQPVVSTFQRGNFPQQSHKTMNMMAMADVMSKYQQQQHQQQQQQRQQQHNLQPQQQHATQKGLEGLLLTNTNTSNNNSSSSSSSSISNLIISHNSASNTGNKMQPTWGQSDAISALWGCSSSSSGCSSGSGSQPSLSPTASSNGNDGSKMMLWAAQSSPQNAATLRDGFKELQRQQPPQQQVPQQQPHAASPTASLTSSSSSSNGWSASHYGKPNIWELPGSTGQRTPASSHDIFTDLLCNLSISQDNSSQQASSKADASDVSSNSSSSAGELLEAANIWRFPEYASSQLYMEEPTGGAAACMQLFNDYLNMN
The following text describes a protein:
Function:
Metalloprotease.
Sequence:
MNRCSSNVGRTGGAQPVSLGSGCVYVGIVIHELMHAAGFWHEQSRGDRDEFITINWDNIIDGMAYNFQKYNLDRIQYLGAPYDTGSVMHYDAFAFAKNRERPTIITKKQGTELGQRRGFSDVDVMKLNKLYECGKNGGVSTVSTTMAPLVSTELPGKCEDSHKHCKIWSATGECDKNKAWMEWIATTSTCTAINGKHPKFIPPPDGKAARKERVSFSRDMGKLTRVIGCYTSRVQSLAKTGECDKNADYMKLYCSKSCKFCGSASSAACVDHNRYCGAWSERGQCKANADYMKLNCKKSCGLC
The following text describes a protein:
Function:
Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate, leading to folylpolyglutamate derivatives.
Sequence:
MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAFHVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVNQMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEPLLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHAAPFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEWLNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRFANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSWSEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK
The following text describes a protein:
Function:
Vesicle trafficking protein that functions in the secretory pathway (By similarity). Together with SYP61, regulates the post-Golgi trafficking of the aquaporin PIP2-7 to the plasma membrane, thus modulating cell membrane water permeability.
Subcellular Localization:
Cell membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein.
Sequence:
MNDLFSSSFSRFRSGEPSPRRDVAGGGDGVQMANPAGSTGGVNLDKFFEDVESVKEELKELDRLNETLSSCHEQSKTLHNAKAVKDLRSKMDGDVGVALKKAKMIKVKLEALDRANAANRSLPGCGPGSSSDRTRTSVLNGLRKKLMDSMDSFNRLRELISSEYRETVQRRYFTVTGENPDERTLDRLISTGESERFLQKAIQEQGRGRVLDTINEIQERHDAVKDIEKNLRELHQVFLDMAVLVEHQGAQLDDIESHVGRASSFIRGGTDQLQTARVYQKNTRKWTCIAIIILIIIITVVVLAVLKPWNNSSGGGGGGGGGGTTGGSQPNSGTPPNPPQARRLLR