lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine haspin-like protein kinase involved in cell cycle regulation.
Domain:
The KEN and D (destructive) boxes are required for the cell cycle-controlled ALK2 degradation by the anaphase promoting complex (APC) pathway; The protein kinase domain is predicted to be catalytically inactive. However, weak kinase activity was experimentally demonstrated.
Sequence:
MNFDAVADQQMTDRRYFALEVAESDDADSSLNSSSMGSPAVDVGRKVYKITSHKGSAEDESQSFFTSSDSPTSKTRPVGKTIENDDYYGKRSSTGSSLKQLFNKININDTAHSSNKENVSQSVLSENKLLSPSKRLSKQGLTKVTNSKFRTPLRPISNQSTLSRDEPVKDFRSLKFRSGSDFKCWGDEKTSSHVHSSSVNSVNSFTSTTSSSKWKFWKNDNLLSRSLSSRSVNDQDPNFVQPKPTNSLQKKSSISSFHNSIFGGGKHTEKKRNSGFIMPDHQSTKELNHKHSSSNLSFRSLKHKTSHSSLNKLKVRRKGNTQELNHPIKKTCQISLPVPDQVSKDKIQLKLKNSTSLASLSSEVTPINTLDYNDSILQQILQLCDVKYILHDLREAQSLGLFTLNTRSVQLSHNFWQTYHSDMQTSLICKKVCLGALSDLTTSNLISLHELKSLRLIQGTSGVANLLQAYVVPSNQCENDQNLILYLFFKYQGTPLSRCSNIDYSQALSIFWQCSSILYVAESKFQLEHRNLTLDHILIDSKGNVTLIDMKCCRFLNIDNNKASYTRLDHHYFFQGRGTLQFEIYELMRSMLPQPISWATFEPRTNLLWLYHLSSSLLKMAKKAVVSGALNREENILIELTHLLDPARKHSKTIFKKELVIRTCGDLLSLKGEIMQ
The following text describes a protein:
Function:
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Sequence:
MKLAAALLISASAVNAFAPAATHVRSSALNMATETAEKAFAKLPATVKPGVVTGKALTDLLDAAKEQGYAIPGVNIVGSNSINACMEAAAKYGGPIMVTFSKGGGQFIAGKSLSNEADSASIAGTIAGAKHVHEVAKLYGVPVVLHTDHCQKAWLPWIDGLLAASEEHFAATGEPLFSSHMLDLSEEPLEENISICKTYLEKFAKVGILLEFELGVTGGEEDGVDNSDVDSSRLYTQPEEVFYAYEQLSQVEGGAFTCAASFGNVHGVYAPGNVDLQPIILYNSQKYIQEKIGSDDDKPMKFVFHGGSGSSVEDIQYAIGAGVIKMNIDTDTQWAFWDGVRAYEAKYHDYLQGQIGNPEGDDKPNKKYYDPRMSLRAGEESMAARLVKAAEDLKCVNVLN
The following text describes a protein:
Function:
Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as an osmoregulator that prevents loss of water and turgor of the cells.
Miscellaneous:
MISCELLANEOUS: Present with 807 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Peroxisome.
Sequence:
MSAAADRLNLTSGHLNAGRKRSSSSVSLKAAEKPFKVTVIGSGNWGTTIAKVVAENCKGYPEVFAPIVQMWVFEEEINGEKLTEIINTRHQNVKYLPGITLPDNLVANPDLIDSVKDVDIIVFNIPHQFLPRICSQLKGHVDSHVRAISCLKGFEVGAKGVQLLSSYITEELGIQCGALSGANIATEVAQEHWSETTVAYHIPKDFRGEGKDVDHKVLKALFHRPYFHVSVIEDVAGISICGALKNVVALGCGFVEGLGWGNNASAAIQRVGLGEIIRFGQMFFPESREETYYQESAGVADLITTCAGGRNVKVARLMATSGKDAWECEKELLNGQSAQGLITCKEVHEWLETCGSVEDFPLFEAVYQIVYNNYPMKNLPDMIEELDLHED
The following text describes a protein:
Function:
May be involved in pectin and/or xylans biosynthesis in cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLWITRFAGLFSAAMAVIVLSPSLQSFPPAAAIRSSPSPIFRKAPAVFNNGDECLSSGGVCNPSLVHVAITLDVEYLRGSIAAVNSILQHSVCPESVFFHFIAVSEETNLLESLVRSVFPRLKFNIYDFAPETVRGLISSSVRQALEQPLNYARSYLADLLEPCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHANFTKYFTGGFWSEERFSGTFRGRKPCYFNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGDNVRGSCRDLHPGPVSLLHWSGSGKPWIRLDSKRPCPLDALWTPYDLYRHSH
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAQPPFQQQPYYGGQPVYQDQGNPMMHPTDPNDLGMENLQISNQQPAPRKKKKDRHAYHVVEAQGSSQAFNGIPQGGVPPSAFLNADPSLIPSPGGQFLNSPITPQMSQFPAPVNAPFNPTNPATPAEFAARTGPGDAFSANVQTSAQGRVDPDQIPSVPRSRDAIAQYYLKNVYPTFEHHLPPPATVPFVAYDQGNASPKFARLTMNNIPSTADALHSTGLPLGLLLQPLAPLQPGELEIPVLDFGETGPPRCHRCRAYINPFMVFRSGGNKFVCNMCNYANDVPAEYFCATTPQGARVDREQRPELMRGTVEFLVPKEYWSQEPVGLRWIFLIDVGQEALNKGFLEAFCEGILAALYGGDDSTEEDGSSKRKIPEGSKVGFVTFDKDIHFYNMNPALEQAQMLIMPDIEDPFVPLSDGLFVDPYEAKSNITSLLSQLPQLFSQIKNPEPALLPTINAAMAALEKTGGKIVCSLSALPTWGPGRLFLRDDGKQHGGEQDKKLFTTEHPGWRKAADKMVATGVGIDLFLAAPGGGYLDIATIGHVAAATGGETFYYPNFVSPRDNEKLSHEIVRSVTRETGYQALMKVRCSNGLQISSYHGNFIQHTFGADIEFGVIDSDKAMGVLFSYDGKLDSKLDAHFQSALLYTTASGERRVRCSNVIASVSDQPKECMNFVDQDAIYSLIAKEAASKMLAHSLKEIRGALSEKNVDILAGYRKNFSGSHPPGQLVLPEHLKEFSMYILGLIKSRAFKGGQEPSDRRVHDARMIKSMGALELSLYLYPRMIPIHNLAPEDGFANEDGHLRMPPSVRASFARVEEGGVYLVDNGQNCYLWMHGQTSPNLIVDLFGEDKDNLKALDPYLSSLPVLQTHLSAQVRNILEYLKTMRGAKALTIQLARQGLDGAEYEFARLLVEDRNNEAQSYVDWLVHLHRHVQLELTGQRKKDDSGDNSSITSNFAGLRPPYW
The following text describes a protein:
Function:
Probable regulator involved in a circadian clock input pathway, which is required for normal oscillator function. Regulates the expression of clock-regulated genes such as CCA1 and TOC1. Involved in both the phytochrome B (PHYB) and PHYB-independent signaling pathways.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
METTVKNSSSDGEWKVVLPSKGRQGRRRKPKPKGQAEEEEQPWKSDDLEIDPQRQARLKQKMEISLKKIESSSFYTAFLEQLKSPEVSNQIRLVLGSETQLQMVMYGIGSIESYESPRFQLSIAILMKREFDWVGDNIEVFDPVLSATESSYLESLGCSVLSVNEQARREALKPTLFFMPHCEANLYSNLLQANWRMDRLSKIALFGNSFQMYEEQVSFDAEVICATKRIIAAQRVTSEFAIETESDDYFAAFHDSSWHFFSSGIDSELPLFVSD
The following text describes a protein:
Function:
May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair-rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes.
Subcellular Localization:
Nucleus.
Sequence:
MHGYRTYNMESHHAHHDASPVDQKPLVVDLLATQYGKPQTPPPSPNECLSSPDNSLNGSRGSEIPADPSVRRYRTAFTRDQLGRLEKEFYKENYVSRPRRCELAAQLNLPESTIKVWFQNRRMKDKRQRIAVAWPYAAVYSDPAFAASILQAAANSVGMPYPPYAPAAAAAAAAAAAVATNPMMATGMPPMGMPQMPTMQMPGHSGHAGHPSPYGQYRYTPYHIPARPAPPHPAGPHMHHPHMMGSSATGSSYSAGAAGLLGALPSATCYTGLGVGVPKTQTPPLDLQSSSSPHSSTLSLSPVGSDHAKVFDRSPVAQSAPSVPAPAPLTTTSPLPAPGLLMPSAKRPASDMSPPPTTTVIAEPKPKLFKPYKTEA
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MSSDIDELRREIDIVDVISEYLNLEKVGSNYRTNCPFHPDDTPSFYVSPSKQIFKCFGCGVGGDAIKFVSLYEDISYFEAALELAKRYGKKLDLEKISKDEKVYVALDRVCDFYRESLLKNREASEYVKSRGIDPKVARKFDLGYAPSSEALVKVLKENDLLEAYLETKNLLSPTKGVYRDLFLRRVVIPIKDPRGRVIGFGGRRIVEDKSPKYINSPDSRVFKKGENLFGLYEAKEYIKEEGFAILVEGYFDLLRLFSEGIRNVVAPLGTALTQNQANLLSKFTKKVYILYDGDDAGRKAMKSAIPLLLSAGVEVYPVYLPEGYDPDEFIKEFGKEELRRLINSSGELFETLIKTARENLEEKTREFRYYLGFISDGVRRFALASEFHTKYKVPMEILLMKIEKNSQEKEIKLSFKEKIFLKGLIELKPKIDLEVLNLSPELKELAVNALNGEEHLLPKEVLEYQVDNLEKLFNNILRDLQKSGKKRKKRGLKNVNT
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Subcellular Localization:
Secreted.
Sequence:
MSSGGLLLLLGLLTLWEVLTPVSSKDRPKKLGLCPPRPQKPCVKECKNDWSCPGQQKCCNYGCIDECRDPIFVN
The following text describes a protein:
Function:
High-copy suppressor of mutant alleles of ATP-dependent RNA helicase DBP5, which is involved in mRNA export from the nucleus. It may also play an important role in a late stage of NAB2-mRNA export.
Miscellaneous:
MISCELLANEOUS: Present with 2733 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MPLESIWADAPDEEPIKKQKPSHKRSNNNKKNNNSRWSNESSSNNKKKDSVNKVKNNKGNHESKTKNKIKETLPREKKPPHSQGKISPVSESLAINPFSQKATEISPPPVSPSKMKTTKTQSKQDTASKMKLLKKKIEEQREILQKTHHKNQQQQVLMDFLNDEGSSNWVDDDEEELILQRLKTSLKI
The following text describes a protein:
Function:
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, cilium axoneme. Note=Located in the proximal region of respiratory cilia.
Sequence:
MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP
The following text describes a protein:
Function:
Sex differentiation protein controlling female somatic sexual differentiation. May act by promoting the formation of a splicing enhancer complex (By similarity).
Sequence:
MEQTSMGKDSSKTAIAKFVPDDDGVLKHTIKVHQQPTSATEKKGPSMIARSNDLIEEIQIKRRFGEGTKPLFERDDVKVNTVADGESISSKKIKSHKASSPSKGVNGLVKQNSPDVTQKFTKKYGSSENPDFRRHSSYEKDNYHKSNSKSGVHLEGHEGNYRPYFSDPIRERDRLRRLYGSPNERRSRSHSPSSNRRRSSHRSRRGSGSPRSRRYTSRHRRRSNSQDRTSWKHNPEHRTSRRSRTRSPRGNRSRRRSSTSSNEDDEREYRHRHHRSQERSYQNVLPTLPPALTNYPCHYHVAPMLALPGVQHRPFLPMVASVRHLPPQALYGGLAGAMPFIPMPMTAYRPHLGHRYPPPRHKINKKN
The following text describes a protein:
Function:
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MIARILAALADSMEMPVAAGGGSVLGTIKIAVMPIAKVFTMCFLGLLMASKYVNILPPSGRKLLNGLVFSLLLPCLIFSQLGQAVTLQKMLQWWFIPVNVVLGTISGSIIGFIVASIVRPPYPYFKFTIIQIGVGNIGNVPLVLLAALCRDTSNPFGDSEKCSIDGTAYISFGQWVGAIILYTYVYQMFAPPPEGFDAEEENLALKTLPVDAAPEQVPLLTQNFPKDFSPTQDLLPVQSTEPRGRGVSRKGKIAQIFVFLYEKLKLKQIVQPAIVASILAMILGAIPFTKKLIFTNGAPLFFFTDSCMILGDAMIPCILLALGGNLINGPGSSKLGFKTTAAIIIGRLVLVPPVGLGIVTVADKLGFLPADDKMFRFVLLLQHTMPTSVLSGAVANLRGCGRESAAVLFWVHIFAIFSMAGWMVLYINILF
The following text describes a protein:
Function:
Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation.
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Sequence:
MMSLSVRPQRRLLSARVSRSQSFAGVLGSQERGPRSFPAFSPPGPSRKPPALSRVSKMFSVAHPAPKVPQPERLDLVYTALKRGLTAYLEVHQQEQEKLQGQIKESKRNSRLGFLYDLDKIDELYEAYCVQRRLRDGAYNMVRAYSTGSPGSREARDSLAEATRGHREYTESMCVLESELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIEGSGKQVWDSEETVFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVTWSPFDKDDQPSAASTVNKASTVTKRFSTYSQSPPDTPSLREQAFYNMLKRQEELENGTAWSLSSESSDDSSSPQLSGTARHSSAPRPLVQQPEPLPIQVAFRRPETSTSGPMDEEGAVAPALANGHAPYSRTLSHISEASVDAALAEASVEASGLDSLVWGPNLPVHPDPTHGEHPGPVPPALDPGHSATSPTLSTTDPVPSAHLDSVHKAINSSSPELPDPTHSTKSSTSSAISPTHSAPSLTHTTTGSTHKPIVSPLTTAGLTPSTTSPVQTTTSPTQKPVLSTLTPVAPTPSTTGPVQTTTSLSHTVTNLTHTVTSPINKPMVSSLTTSGPSPSTTGPALTTTSPTHTPATPAHKASMSTHPTRSPTPNAEGLVQTTMSTTRPVTSPTLITVSPSTFLDLATLSSPSANTDPTLPGTDPLSCSYPASTPCSQADPIASSTSHPSPTCSSWEPLTSPSPNPPEAICQSPGPPPTPLSPVPQQSDPSLARAAQVPLPGAARGAGDRRLEEALGALMAALDDYRGQFPELQGLEQEVTRLESLLMQRQGLTRSRASSLSITVEHALESFSFLNEDEDENNDGPGDRPSSSPEPGAEESLDSPGARPLSTECAALDAALVQHLYHCSRLLLKLGTFGPLRCQEAWALERLLREARVFEAVCELSRRWDIPATSAQEVVQFSASRPGFLTFWDQCTEGLSPFICPVERVLLTFCNQYSARLSLRQPGLAEAVCFKFLEDALGQKLPRRPQPGPGEQLTIFQFWSYVEALDSSSMEAYVTETAEEVLLVRNLNSDDQAIVLKALRLAPEGRLQRDGLRALSSLLVHGNNRVMAAVSTQLRSLSLGPAFRERALLCFLDQLEDEDVQMRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEAGEWEIWVKLSSGTSWLLGVGVRCGQGWEDKDGARTTPDLILIHYRGRGSVCPSTVGGVTGCPAPHLWARQHGQHSILKFPPTGPQCPFPPTFRAYEALAGRVRAGSRHPSLTDSYQ
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MPLRLLESTNFNFQSNPPAEVRIHGQKVLGTFSTDADRGYCNDDRNRRVFLEPDNEVDFDYTKGFEEHVAFGEDPRVTSLMNVLSWMRDHRSLLIKSGTLDTTVSRLNVDFVGRRGLFRNLLEAGGDKDLDIRLLVTLYRGTYFISGIWKNDRKLTRDQQMDGCNPDTPTPVDENASFYAMMSANCGRHRLLFSSEVQAERKDEITPPQRNYLNIRTIPKE
The following text describes a protein:
Function:
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MASSALRSCGVAAVFPSALSSSRSKFATAIALPGVSSNASSRFTMSAEWMPGQPRPPYLDGSAPGDYGFDPLRLGEVPENLERFKESELIHCRWAMLAVPGMLVPEALGLGNWVKAQEWAAVPGGQATYLGNPVPWGTLPTILVIEFLGIAFVEHQRSMEKDPEKKKYPGGAFDPLGFSKDPVKFKEYKIKEIKNGRLALLAFVGFCVQQSAYPGTGPLENLATHLADPWHNNIGDVLIPRSIFP
The following text describes a protein:
Function:
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH
The following text describes a protein:
Function:
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate.
Sequence:
MKAIILAAGEGLRCRPLTLTRSKVMLPVANRPILEHVISSLEKNGIKEIILIVGYEKERIMNYFEDGLNFGVNITYVEQKAQLGTAHAIEQAKKLISPEDSEFLVLNGDNLVESKTIADLLNNYKGDASLLTVRMEDTAGYGVVLKENKRVTRILEKRPGDLSHIVNTGIYIFTPQVFETIEKTPISENGEYAITDTLQLMIDEGKIVTSIPTESKWLDAVHAWDLLKANSTVLNSSRNLKQEGELEEGVIIRGKVAIGKNSRIRAGTYIVGPVVIGENCDIGPNVVILPSTTIGDNVSIRSFTEIQNSIIMNDCRISSHGQISNCIIGSNNTLGPGFTAEEKENLEININCKIHSAPKLGTIFGDDNRIGGRVLVKAGVMIAVNCQVESGNTIYRDLPRDSVVL
The following text describes a protein:
Function:
Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as itraconazole, posaconazole, and voriconazole.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAMQPSYPAPFGAAAISSSAGQEVASTIRRQFTDADADRIVETPLGEKADSSDTAGPDSEDGIDQEGHDKITALARSLSQISQKSAGPTNTFLDPSSDPELDPNSDKFSSRKWMKNLLHIKTRDPDRYPRRTAGVSFRNLNAYGYGTAADYQADVANMWLKGFGWLRSILGCRNRVQIDILRNFEGFVRSGEMLVVLGRPGSGCSTFLKTIAGETHGLWLDEGTHIQYEGISWDEMHSRFRGEVIYQAETEIHFPQLTAGETLLFAAQARTPANRFPGVSREQYATHMRDVVMTMLGLSHTVNTRIGNEYIRGVSGGERKRVSIAETILCGCPLQCWDNSTRGLDSSTALEFVKNLRLSTDYTGSTAIVAIYQASQAIYDIFDKVIVLYEGRQIYFGKASDAKRFFIDMGFDCPDRQTTGDFLTSLTSPSERLVRKGYEALVPRTPDEFAARWRESAERQRLLADIEAFENESPLGGSKYKEFTVSRAAEKAKGTRAPSPYTLSYPMQIRLCLRRGFLRLKGDMSMTLATVIGNSIMAFIVSSVFYNLDQTTNSFFSRGALLFFAILLNAFASSLEILTLWQQRPIVEKHDKYALYHPSAEAISSMIVDLPSKFLVSVVFNLILYFMTNLRRTPGHFFVFYLFSVTITLTMSNIFRWIGAISRSMAQAMVPSSIFMMILVIYTGFTIPVRDMHPWFKWLNYLNPIGYAFESLMINEFSDRRFPCAQYVPAGPGYEDVPLSSKICSQKGAVAGQDYVDGDAFINTSYRYFSSHLWRNYGIILGFFFFFLAAYIICSELVRAKPSKGEILVFPRGKIPAFVKKSRRDGDLEGAPTFEKQQLDNAGHDSTAAIVKQTSIFHWQDVCYDIKVKGETRRILDHIDGWVKPGTLTALMGVTGAGKTSLLDVLANRVTMGVITGEMLVDGRMRDDSFQRKTGYVQQQDLHLETSTVREALIFSATLRQPASTPHKEKLAYVEEVIKMLNMEEYAEAVVGVLGEGLNVEQRKRLTIGVELAAKPALLCFFDEPTSGLDSQTAWSICTLMRKLADHGQAILCTIHQPSAILMQQFDRLLFLAKGGKTVYFGELGPNMETLIKYFENKGSSKCPKNANPAEWMLEVIGAAPGSHADQDWPEVWNNSPERAQVRAELARMKEELLQRPPPPRTKEYGEFAMPLWAQFLVCLQRMFQQYWRSPSYIYSKAATSIIPPLFIGFTFWREPTSLQGLQNQMFAIFMLLVIFPNLVQQMMPYFVTQRALYEVRERPSKAYSWKAFMLASILVELPWNILMAVPAYFCWYYPIGLYRNAYPTDSVTERGGTMFLLILIFMMFTSTFSSMIIAGIEQPETGGNIAQLLFSLCLIFNGVLASPSALPGFWIFMYRVSPFTYLVSAVLSVGLAGTSVKCSDIEILHVPPPQGQNCSSFLDAYVQMSHGRLLNPEATSDCQVCPVADTDTFLAQVSISYSDRWRNVGLLFVYIVFNIFAAIFLYWLIRVPKKRSRKIKEE
The following text describes a protein:
Function:
Cell wall hydrolase that cleaves gamma-D-glutamate-meso-diaminopimelate bonds in peptidoglycan. LytF is necessary and sufficient for vegetative daughter cell separation, and also seems to play a role in cell autolysis.
Subcellular Localization:
Secreted, cell wall. Note=LytF is localized at cell separation sites and cell poles of rod-shaped cells during vegetative growth.
Domain:
The N-terminal domain contains LysM domains that are thought to be involved in peptidoglycan binding, while the C-terminal domain is endowed with the catalytic activity.
Sequence:
MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTYNTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSLWLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSKSSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTKSSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLYVGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREKNNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGGTTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHVGIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKNLTLKGCQGHLLQSGDVKGITVDSSIDAVFVAVGLSENNPGLTIYKIAQGKEPREFITYDDPRLLSENQEPILIRDMKFLSESSSICIVLSNGEILMIRTEVSPDEDVVESIGDVENGILAAQWSPDEQVFALVTGNSTILLMSKNFDTIAEVDMLEKDLTEFNKHVSVGWGRAETQFRGKRVRAKLRDPTLPEKVDEGKLSPYDSSEVTLSWRGDGAYVSVNRIENGVRRAIRVYNREGALDSISEPVDFMEGQVGWRPSGALIAAVQRGEDDRKTQVIFFERNGLRHGEFTLRDVEDQPVSDVSWNISSDVLAVCYSSMVQFWTRSNYYWYLKQEFRFDSNIKFQWHPEKAYTCYIYSKDKVEILDFENVYSNDTCLPPNDLGVMPVIDGNVLKITPLSLVNIPPPMSLHEYELPFNCRSVSVSSNSDCIFAMGPDQLHRLFVDNWDITSAGNWDIASYAPGLIFKSVVCLSSTEVLLLADDADTTTVIFFNVKDDDLVMQDVHQYEKRIIKATTAVKENVFYLQTIGGDILRYDLATCEMKDVGVKFPAECYSFQACMANEIPVFIGLSRAGRLYADTRLLAQGCTSFLCVGNMLAFTTNKHILKFVCLKGYVDDFFVVDDSAIKDHDERCRNVERGSELVTLLPSKMSIVLQMPRGNLETIHPRLMVLNGVRDNIVKLDYGKAFIISRTHRIDLNLLFDYDPEKFFSNITLFVEQVKRTDYLDLFLSSLKSEDVTKTMYADTFSSRGSSATTCEDKVNKVCEAIRRTLQTSFSKTHLQTVLTSYLCQQPPDVTAALSIVSDLKVENEGKAEEAIKHISFLTDINMLFDFALGTYDLKLALMIAQQSQKDPREYIPFLRAFQKETPLRRKYNIDCHLKRFESALQNLSEIENAFDEVKNFVVSHKLYSEALKLYRYKKEQRKELLLLYANYLKDNGKAKEAAIAFESVGEYDRAIDAFKSAGAWRECLSIMESQSYPKHKIEEAATDLLALCLEKREYNDAGYLNVFYLRNKTEAIQNFCKGTMYAEAIRIAHGSNENLYEAVLLSSLNESFVEASETIADYKGQVKAQTERLQVLRTKKQENPAAWYEGIVDDGTPDDISLASTSMTSNPSLYTRYTGTSQSSRMTRNTARNRKRMERKRARGKKGTIFEEEYLVNSLRRLITRVNETRDEQQRLIEALMRCDMFAQANEIQHGFSQVIDTLREKATFIFSDPVKPVSSNEGLPEQSKSENLPIPQISPFEKFGILA
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MAFSISSSSSSSSSIACCAPPRCVSRACRCGTCLDAFIATSTSPPPSSSSAHAAPSRLAPLTTPFARRSVAIAVDSHARQHQTLSVLQEMEFDVVVVGAGIIGLTVANRILEETRFSVVVVDAKRPCAGATGAGQGYVWLNHRNPASKTWGLAHRSKLLWEQLVADLADAGSDPLSAIGWQNTGSLLVANSVEEARGLQAHVGAMATAGVDAEFLTASELQKIEPSLKVGHEGGAAFVPGDSQIDAALAVEFFRKRNLAYRVEGRYMELFDSPVEELYRSSADGSIEVVQTSRHKLRSREAVIVAAGAWSPNILTRAAQEWRLPLIPPVKPRKGHLLVLEGLPSLKINHGLMEFEYTANYTTAHSTQCSQPEDVSTPSLVTDPTVISHDSFRVAMTASTDKSGRLLLGSSREFSGFSTAHHYEAIEGILSRASEYFPALKDISVEDVLEKQTIRTGLRPYAFGGVPLVGPVPGVERLMLATGHEGSGLCMALGTAEMLVTRLLGKETVFDVDPYLPASRLCHSQTNAQTLA
The following text describes a protein:
Function:
Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. Also inhibits the activity of ATP2A2/SERCA2 and ATP2A3/SERCA3.
Subcellular Localization:
Sarcoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MSGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVITS
The following text describes a protein:
Function:
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MLQRLAASSRWRAAVLATSAARCLSSGSVTITDPLNYWAGRRKAGQEKCSTENVYEPATGRILCHLELCGGDEVNQAVKAAKSAFGYWSKMSGMERARIMINAAHIMESRREEIAEMEVVNNGKSITEARLDVDSARLCIEYYAGLASTLAGQHVQLAGGSFAYTRREPLGVCAGIGAWNYPFQIAAWKSAPALACGNSMVFKPSPVTPVTAVLLAEIYAKAGAPEGLFNVVQGGQETGSLLCHHPDVAKVSFTGSVPTGQKIMEMASKGIKPVTLELGGKSPLIIFEDSDVENAVKGALMANFLSQGQVCSNGTRVFVQKDILPEFVDVVVKRTKAISIGDPLLESTRMGALVSRPHLDKVLSYVQQAKAEGATVLCGGEPFVPSDPKLRGGYYMSPCVLGDCTDDMTCVKEEIFGPVMSVLSFETEEEALQRANDTTLGLAAGIFTRDVKRAHRVVEHLKAGSCFINNYNVTPVEVPFGGFKMSGIGRENGQVTIEFYSQMKTVFVEMGDVDSLF
The following text describes a protein:
Function:
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal glycosyl residue.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MSAKIKGEYSSRSFVSRKWTILLCLGSFCVGMFFTNRMWNIPESKGMSHPSVTEAERLKLVSEGCNPKALYQKEVKRDPQALFGEVANTHIALQTLDKTISSLEMELAAARSVQESLQNGAPLSDDMGKKQPQEQRRFLMVVGINTAFSSRKRRDSIRATWMPQGEKRKRLEEEKGIIIRFVIGHSATTGGILDRAIEAEDRKHGDFLRLDHVEGYLELSGKTKTYFSTAFSMWDADFYVKVDDDVHVNIATLGETLVRHRKKPRVYIGCMKSGPVLSQKGVRYHEPEYWKFGENGNKYFRHATGQLYAISRDLASYISINQHVLHKYANEDVSLGAWFIGIDVKHIDDRRLCCGTPPDCEWKAQAGNICVASFDWSCSGICRSADRIKEVHRRCGEGEKALWSATF
The following text describes a protein:
Function:
May be a transcriptional corepressor with KLF4.
Subcellular Localization:
Nucleus.
Sequence:
MSRRKAGCTPRRIDPAPAANPDDETEMPDLVICVKPEPDARPLQAPGLGPFNPKEVPAPGLSEGESRHPHGPVPAAGLIHALGLRSQCAAWTPLTPNPQDRQPWTDKHPDLLTCGRCTQTFPLEAITAFMDHKKLGCQLFRGPSPSQGSERDDLKALSCLRCGRQFTGAWKLLRHVQWDHGLSIYQTEPELPEAPLLGLAEVAAAVSAVAGPEAEAKGPRVGHPRRSPTCPMCAKTLSSFSNLKVHMRSHTGERPYACDQCPYACAQSSKLNRHKKTHRQLQPQSPCSAGSSQELASAAPPEPAAHAAAPASALPCSGGEGAGAAATAGVQEPGAPGSGAQAGPGGDGWAVATKEQRTDPTKTQKTSPKKAPKAVGKSRGPGPGGSCEFCGKHFTNSSNLTVHRRSHTGERPYACELCSYACAQSSKLNRHRRMHGLGPGGPRFECPHCCVPFGLRATLDKHLRQKHPEVGGDA
The following text describes a protein:
Function:
Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MHHIELLLTLLALMFTRTLETCTSRFNITAVRGEPFYLKYCPSASEHKNEATAIKWYKSNESHGRIELNSRNSPRITLHDYILEFWPAELEDSGSYFFQMGNDTREWKLNVIARRKYSCFAEKQLISKIVEVQKSLHINCEHTYYQKLSNRTSLYKNCEKIENNKNPALQKNAEFNDQGYYTCVFFIHHNGKLFNVTKTFNVTVVGDRSKIIPVLLGPKLNHVKVELGKDVELNCSALANEKDAVYWNVWEENGKEPNVHEEDITRIRTLEGKLYASRILRIENINEKNLLFSYNCSVASEGGTDTIHFVLLKKEDMADISGYVFTRGMIIAVLISVGVVCLVIIGVIYRVDLALFYRHCMGKDETLTDGKTYDAFVSYLRECGPENGEEYTFAVKILPEVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVSDFTFFPQSLKLLKSHRVLKWNADKPPSYNSRFWKNLLYLMPAKMVKPCRAESEDLTVLSKF