lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol. Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (By similarity). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity (By similarity); [ANGPTL3(17-221)]: In vitro inhibits LPL activity; not effective on GPIHBP1-stabilized LPL; Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration. Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling. May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS (By similarity).
Miscellaneous:
MISCELLANEOUS: Was suggested to inhibit LPL through a direct mechanism; however, the necessary concentration to achieve in vitro inhibition is at least 30-fold higher than ANGPTL3 plasma concentration.
Subcellular Localization:
Secreted. Cell projection, lamellipodium. Note=Colocalized with HSPG2 and activated ITGB3 on podocytes.
Domain:
The fibrinogen C-terminal domain is sufficient to mediate endothelial cell adhesion.
Sequence:
MFTIKLLLFIVPLVISSRIDQDNSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELRRTTYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSSKPRAPRTTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHFNCPEGYSGGWWWHDECGENNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE
The following text describes a protein:
Function:
Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Subcellular Localization:
Nucleus.
Sequence:
MTDHEETSTQKAVSLTDTNDLFQLLNELESRFLPMRSREKKEVDIGRIQQRPHKIGEYPGSVYIEIPIEIKNKIMEETNQFSQDFKPIQSLHISLTKEFSLREHQIPLFVQEVRKKIKRLPTFTITFGQLELLLNPEQNTEFLSIQVTSPEILSLIDLLDTVMMSFNLEKYYEERKIHSSLMYRTEHLKEPYELSSFNKCLLSFKPATIKIRLGEIVYTCVLGGYSM
The following text describes a protein:
Function:
Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular Localization:
Cytoplasm.
Sequence:
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPEMPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
The following text describes a protein:
Function:
Transcription factor that regulates CIT2 gene expression. Binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (UASR) in the CIT2 promoter. The core binding site is 5'-GGTCAC-3'.
Miscellaneous:
MISCELLANEOUS: Present with 1050 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Domain:
The 9aaTAD motifs are transactivation domains present in a large number of yeast and animal transcription factors.
Sequence:
MMNNNESEAENQRLLDELMNQTKVLQETLDFSLVTPTPHHNDDYKIHGSAYPGGETPAQQHEKLSYINTHNSNDNNNLMGSQARSNSQTPTASTIYEEAESQSSYLDDMFRTSQGGRPVTQNSISSIGQGPLRSSYSMAYDSPVDRAMNTPLQQQEGLKAELPHDFLFQHGTDDTMYNLTDDLSSSLSSSINSDMMTPNTYSSSFSYNPQSLGPASVSSTYSPKVRSPSSSFRAGSFLSSSFRHGSINTPRTRHTSISSNMTENIGPGSVPKILGGLTSDEKLRRKREFHNAVERRRRELIKQKIKELGQLVPPSLLNYDDLGKQIKPNKGIILDRTVEYLQYLAEILEIQARKKKALLAKIKELEEKKSSVAALSPFTNNHHASSGQNNSENSEERIIDIRSVPNALMNEQNSKAELHNWEPPLYDSVGNHNHAGTMESHPHTNIHEELKEFLSGDLIEAEDNAKLMFGDDNSNPADYLLEFGSG
The following text describes a protein:
Function:
Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.
Sequence:
MGYRLSALTYVQGDLFEESPRPAVLAHACNCLGSWGSGVAAGFKQKFPGAFVEYKRHCDKYSDDNSALLGTCQLIETHDAQTGELVYVACLFTSVRFGARVDGPEQIVKQTKLAMQDLQKQLAKMSGPIDGNSTVHMPKINAGLFRVPWRDTEKVLEEVGQPCTVYVID
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MGILLSRFRSKPSTKEVLEGIDKELKSIDEFQQDTIERQRRVARRLLVIFILVYIIAIASFIFITSIQKFKLYYFTGLVTFALVTWSSHRGIKWYFTRQMVSNSEKSVELRKKKKKILEEVMDTETYKIAKEILDRFGDKPQNTPFEVKPAQSPSMNVRPSAPGTELRHRQVEQSIPRANGPLQPNPAIVGSAMKLNQQAKQQQQQQQQQHMLSTQRPVGMNYGPAPTRPLPRPILARERGVLDRMMDLFVGDGPHQRYALICRHCSGHNGMALQEEFEYVSYYCCYCYQFNPPRKMRPMGPRLPVPPSPAPVAASSKVPQEKKPDEKSEKNEESDEKGERTDDRENISDNSDESTGDDASSDEESEVAPIVKTENNHEASEDMEIDSPEGDKAISADEAGQDTSSLR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEVTFKDVAIFLTQWEWGSLADAQRELYTSVMLENYGHLRSLGAGRPKPQCIRQLEKGEDPWVPEPPAHHKWIFLKEAWTEEIREEQLPDTVFAESHGNVSHLPRRGRSLKNQWRSRRKRDRPVERRKAQKPVPVKEEPFERFKCGNRESFVTHMRLHTGEQPYKCGVCARSFRQKGYLTCHMKVHSGDRNFQCPDCQKSFKTKGKLNKHKRVHTLEKSFECLECGKAFREKYNLTRHEKIHKGIKPHMCLQCERRFSEKSSLIDHIRVHTGEKPFQCPECQRYFKRKGSLRVHMRVHTGAKPYKCLECGKAFRQNGNLKKHKLRHRDVKPWVCLQCGRSFRGRGRLLTHMRVHSGEKPVQCPECQRYFKRKGSLQVHMRVHAGVKPFESLECGKTFQEKGNLRKHEGRHKDLKPCTCLQCERRFRDSDRLITHMRAHTGERPFPCPLCQKKFKTRGCLRKHMRVHTVAKPFKCLQCGMTFCQKGSLRKHERRHKDIKPCVCLHCERSFRDKDHLITHMRIHTGERPFLCLQCQKKFKTRGSLRRHLRVHTGEKPFECLECGKAFNRNSNLTVHKKIHMAAKPHVCPRCKKSFRFKCQLVAHKTLYAGGKPCEYTDGKLAAR
The following text describes a protein:
Function:
Cytosolic alpha-glucanotransferase essential for the cytosolic metabolism of maltose, an intermediate on the pathway by which starch is converted to sucrose in leaves at night. Metabolizes maltose exported from the chloroplast and is specific for beta-maltose. May play a role in freezing tolerance. Temperature drop induces inactivation of DPE2 that leads to rapid accumulation of maltose, a solute that protects cells from freezing damage.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MMNLGSLSLSTSKSSKPMVSISFWIPYFTHWGESLLVCGSAPGLGSGNVKKGLLLKPSQQDDQLIWSGSVSVPPGFSSDYCYYVVDDSKSVLRSEFGMKRKLVVPETLTGGESVHLRDLWQSGDQALPFRSAFKDVIFHHSFDVKVEKPLGVFMNKSDQDDSVVVQFKICCPDIGEGTSVYVLGTPEKLGNWKVENGLRLNYVDDSIWEADCLIPKADFPIKYRYCKVQKEDSIGFESGGNRELSLHSIGSKQEYIVMSDGLFRAMPWRGAGVAVPMFSVRSEDDVGVGEFLDLKLLVDWAVDSGLHLVQLLPVNDTSVHKMWWDSYPYSSLSVFALHPLYLRVQALSERLPEDIKEEIQKAKNQLDKNDVDYEATMETKLSIAKKIFDIEKDQTLNSSTFQKFFSENEGWLKPYAAFCFLRDFFETSDHSQWGTFSDYTDDKLEKLISKDNLHYNTICFHYYIQYHLHVQLSAAAEYARKKGVVLKGDLPIGVDRNSVDTWVYRNLFRMNTSTGAPPDYFDKNGQNWGFPTYNWEEMSKDNYAWWRARLTQMGKYFTAYRIDHILGFFRIWELPAHAMTGLVGKFRPSIPLSQEELEKEGIWDFDRLSKPYIQKKFLEEKFGDFWPFIASNFLNETQKDMYEFKEDCNTEKKIVAKLKSLAEKSLLLENEDKVRRDVFDILRNVVLIKDPEDARKFYPRFNIEDTSSFQDLDDHSKNVLKRLYYDYYFQRQEDLWRKNALKTLPALLNSSNMLACGEDLGLIPSCVHPVMQELGLVGLRIQRMPSESDVKFGIPSNYDYMTVCAPSCHDCSTLRAWWEEDEERRQQYFKEVIGVDGIPPSQCIPEITHFILRQHVEAPSMWAIFPLQDMMALKEEYTTRPATEETINDPTNPKHYWRYRVHVTLDSLLKDTDLKSTIKNLVSSSGRSVPANVSGEDINKSRGEVIANGSTKPNP
The following text describes a protein:
Function:
Binds directly to 16S ribosomal RNA.
Sequence:
MANSAQARKRARQSVKQRAHNASLRTAFRTAVKKVLKAVEAGDKAAAQAVYQESVKVIDRIADKGVFHKNKAARHKSRLSAKVKALA
The following text describes a protein:
Function:
Plays a major role in chloroplast RNA editing. Acts as a site-recognition transacting factor involved in the edition of the site 2 of ndhD (ndhD-2), which encodes a subunit of the NDH complex.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASLPFNTIPNKVPFSVSSKPSSKHHDEQAHSPSSTSYFHRVSSLCKNGEIKEALSLVTEMDFRNLRIGPEIYGEILQGCVYERDLSTGKQIHARILKNGDFYARNEYIETKLVIFYAKCDALEIAEVLFSKLRVRNVFSWAAIIGVKCRIGLCEGALMGFVEMLENEIFPDNFVVPNVCKACGALKWSRFGRGVHGYVVKSGLEDCVFVASSLADMYGKCGVLDDASKVFDEIPDRNAVAWNALMVGYVQNGKNEEAIRLFSDMRKQGVEPTRVTVSTCLSASANMGGVEEGKQSHAIAIVNGMELDNILGTSLLNFYCKVGLIEYAEMVFDRMFEKDVVTWNLIISGYVQQGLVEDAIYMCQLMRLEKLKYDCVTLATLMSAAARTENLKLGKEVQCYCIRHSFESDIVLASTVMDMYAKCGSIVDAKKVFDSTVEKDLILWNTLLAAYAESGLSGEALRLFYGMQLEGVPPNVITWNLIILSLLRNGQVDEAKDMFLQMQSSGIIPNLISWTTMMNGMVQNGCSEEAILFLRKMQESGLRPNAFSITVALSACAHLASLHIGRTIHGYIIRNLQHSSLVSIETSLVDMYAKCGDINKAEKVFGSKLYSELPLSNAMISAYALYGNLKEAIALYRSLEGVGLKPDNITITNVLSACNHAGDINQAIEIFTDIVSKRSMKPCLEHYGLMVDLLASAGETEKALRLIEEMPFKPDARMIQSLVASCNKQRKTELVDYLSRKLLESEPENSGNYVTISNAYAVEGSWDEVVKMREMMKAKGLKKKPGCSWIQITGEEGVHVFVANDKTHTRINEIQMMLALLLYDMGTGSK
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MRCSVAVRASSIYVKNPQLRKSFLHSNYVQLIQESPNFLILQHNNLLPREAKSLRTELKAKVPGSKLQVIRGSIFHHALKVYESIDRLSNGCVDMQKVNLIETHKKAQKIKLDIDNLFVGPLAIFTLGPKLSPEAIRGFMSVLKGYQNKILLLGIRAESKGMDPFEVENLSKIPSLEFLQSSLLSVLSSPASQLRRILDLSKANVAYTLERREPSE
The following text describes a protein:
Function:
Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
Subcellular Localization:
Cytoplasm.
Sequence:
MLAGGAGRFASTLPLTERGGGDPVLIAINCRPFCLSVFLLRAVVLAHSLRDNGTKAKLVALYTPDTLQYATIKELQTVYDEIIPVQTATNRTPANLWLMDRPDLIATFTKIELWRQTQFRKIVYIDCDVVAVRAPDELLTLEEDFAAAPDVGWPDIFNSGVMVLRPNLQDYYALKALAERGISFDGADQGLLNMHFRNWHRLSFTYNCTPSANYQYIPAYKHFQSTISLIHFIGAQKPWNLPRQVLPVDSPYNQLLGRWWAIYDRHYRPVVTVSETQHDQHLASSSEEALGTLYETSFKSESPSLQPHTVRSHSHAQVEQAPHEEVFYDQGSTPHGLEVSHADHAQAVPEEHHPIQSEAALVRSAVPQYVRGEEHVSAYVLPHSSQPAFTIQSEQPTCQAASAPSPPSEPSAANEIYQAHLKPEPVIENQQQPPAPSVPPDKAETFEAPKAEWDAVREPPPLNSKPEGFALAERTYTMSDDQRLFQPPASYPEAPKNMWYQVPETKPEPEKITQIFPWESRAPKPTRVFLEDQPSTVSTESALASTREESRSSIGSRTSCTAEGPSTATWETYSRSNAWDEVPEINKYIQSIQHGRKAKVQVISGGPSPGTEPSSWKTIDHGPMGMRVTDFPTEVERPSLPVTPAPIRRSFAQASGDEAADEQLPIAEGVPKQEDWVGLTVDAFLHLLRATYLYWKFTESVGTPRRASPAPVRNLGKGRFIT
The following text describes a protein:
Function:
Cell wall peptidoglycan (PG) DD-endopeptidase essential for cell growth and elongation. Hydrolyzes peptide cross-links which covalently connect adjacent PG strands probably to allow insertion of new glycans and thus cell wall expansion. Degrades purified whole PG sacculi in vitro. Releases predominantly short glycan chains from the PG. Cleaves D,D cross-linked muropeptides specifically preferring dimeric tetrapeptide-tetrapeptide (D44) substrates and has only little activity on dimeric tetrapeptide-pentapeptide (D45) substrates. Also converts more than 50% of tetrapeptide-tripeptide (D43) to product as well as more than 50% of D43M, which contains D-Met instead of D-Ala in the fourth position of the acceptor moiety. Cleaves the D,D bond between diaminopimelic acid (DAP) and D-Ala of the PG substrate in vitro. No cleavage of L,D bond connecting two DAP moieties.
Subcellular Localization:
Periplasm. Note=Localizes to the lateral cell wall. Localizes uniformly to the periphery of the cell with no distinct pattern in the absence of an osmotic challenge. Not observed at the division site at any time point.
Domain:
N-terminal domain I (1-160) inhibits catalytic activity by blocking substrate access to the active site present in domain III (266-430).
Sequence:
MISKSIILRFSELSMRKKATLVGLPLLAVAAISSSLNSPTRQQRIELSLPESPLVQFSSAEHTVEVVKVGHPDYEYEIKPGDNLSTIFNQLGFAYTELMKVMETDLNYLALDTLRPGNVLRFWKGSDNTLAKMELEFSLVDRAVYTRLNDGSYEFEERKIPGTWKVEPLIGEVDGSFSLSANRAGLGAADVDQIVTLLKDKINFGRDLRRGDRFEVVLSRQLVGEKLTGNSEIQAIKIFNRGKEITAYLHQDGQYYDKNGDSLQRAFQRYPVDSKWRISSNFDPRRLHPVTKRVAPHNGTDFAMPIGTPVYTSGDGVVVMTRNHPYAGNYVVIQHGNTYMTRYLHLSKILVKKGQKVSRGQRIGLSGNTGRVTGPHLHYELIVRGRPVNAMKANIPMASSVPKKEMAQFIAKRKELDQMLARQESMLAAQ
The following text describes a protein:
Function:
Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase.
Subcellular Localization:
Mitochondrion.
Sequence:
MATVPEIKIMRSESLGHRSDVSSPEAKLGMRVEDLWDEQKPQLSPNEKLNACFESIPVSAFPLSSDSQDIEIRSDTSLAEAVQTLSKFKVLSAPVVDVDAPEDASWIDRYIGIVEFPGIVVWLLHQLEPPSPRSPAVAASNGFSHDFTTDVLDNGDSAVTSGNFFEVLTSSELYKNTKVRDISGTFRWAPFLALQKENSFLTMLLLLSKYKMKSIPVVDLGVAKIENIITQSGVIHMLAECAGLLWFEDWGIKTLSEVGLPIMSKDHIIKIYEDEPVLQAFKLMRRKRIGGIPVIERNSEKPVGNISLRDVQFLLTAPEIYHDYRSITTKNFLVSVREHLEKCGDTSAPIMSGVIACTKNHTLKELILMLDAEKIHRIYVVDDFGNLEGLITLRDIIARLVHEPSGYFGDFFDGVMPLPENYRV
The following text describes a protein:
Function:
Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by promoting decapping and leading to accurate 5'-3' mRNA decay. LSM1A and LSM1B are essential for the formation of the cytoplasmic LSM1-LSM7 complex which regulates developmental gene expression by the decapping of specific development-related transcripts. Required for P-body formation during heat stress.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MSWAGPDEILLSTSLAGFLDKKLIVLLRDGRKLLGTLCSFDQFANVVLQGACERVIVGEQYCDVPLGLYVIRGENVVLIGELDREKDELPAHMTCVSEAEIRKAEKAEREARDLKGTMRKRMEFLDFD
The following text describes a protein:
Function:
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Required for the biosynthesis of D-biotin that prevents light-mediated cell death and modulates defense gene expression, probably by avoiding hydrogen peroxide H(2)O(2) accumulation.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome. Note=The cytosolic localization observed in PubMed:16299174 is probably due to the lack of PTS1 domain at the C-terminus of the reporter gene construct.
Domain:
The C-terminus PTS1 domain (474-476) is required for biotin biosynthesis activity and peroxisomal subcellular localization.
Sequence:
MADHSWDKTVEEAVNVLESRQILRSLRPICMSRQNEEEIVKSRANGGDGYEVFDGLCQWDRTSVEVSVSIPTFQKWLHDEPSNGEEIFSGDALAECRKGRFKKLLLFSGNDYLGLSSHPTISNAAANAVKEYGMGPKGSALICGYTTYHRLLESSLAQLKKKEDCLVCPTGFAANMAAMVAIGSVASLLAASGKPLKNEKVAIFSDALNHASIIDGVRLAERQGNVEVFVYRHCDMYHLNSLLSNCKMKRKVVVTDSLFSMDGDFAPMEELSQLRKKYGFLLVIDDAHGTFVCGENGGGVAEEFNCEADVDLCVGTLSKAAGCHGGFIACSKKWKQLIQSRGRSFIFSTAIPVPMAAAAYAAVVVARKEIWRRKAIWERVKEFKELSGVDISSPIISLVVGNQEKALKASRYLLKSGFHVMAIRPPTVPPNSCRLRVTLSAAHTTEDVKKLITALSSCLDFDNTATHIPSFLFPKL
The following text describes a protein:
Function:
Orphan receptor.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
SENYTYLYPDWHELLDCPQKSLPWQSVIIPTLYFLIFFTGFIGNLCVIVIMASKHKNRRLVDTFVINLAVADLVFVCTLPFWGISAAKENQWDFGDFLCKFSSYVIAVNRFSNIFFLTCMSVDRYLAVVRMLDSRYLRSNQCVRLTCCVIWLASIALGVPSLIYRRVEENGAARLCTEIADSAVFNGISLVALFLAFVLPVVIIVACYCSILVKLRNPPGLQNPKTEQRRRHSLKIVLVIIVAFVVSWLPFNVFKTILIACQLQFASLSCASQTTLARGLTLSSCFAFLNSCANPAIYIFLDHHFRHRALRFCLGWFGPQIKRRSGAPAASSSGLTIDSYSVS
The following text describes a protein:
Function:
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Subcellular Localization:
Nucleus.
Sequence:
MAGQVTAGAVEYLKKNIPPSEKGFPDGFVVQMLELEKTQGKIAKYRFLANDGQSRIRGVLPSTMTSDVETSKTVQNFGLLRVKEAVCNVVHGEEVILCLKCEVAGPSLGQELRSGPQPAPAALKPEEMTPTKVSQTPSFSFNTTPPPASPPLASPMFTPEAKPFPMSTPKPASKIMEAERNKAAASNRMASSGSRRVYPLVSLNPYQGNWTIQVRVTNKGPMRTFKTARGDGNVFSVELMDEEGTEIQATMWREAADKFWEVFQLHKVYYISGGQLKMANRKFSTVKNEYELNLGANSRVEEVEDTAGSPSSIPTAKYNFVHFDALGPYVGGRELIDVVGVLKSAAPTTSIRRKINGEELTKREITLADQSEKTVAVTLWGKQALEEGAQLEALQDSAPVIAVRSLRVGDYQGVSLSTTGRSLVLINPDLPETQAIRKWYDGEGKTAALTSAGAGLASASKGAGGSRSIYDDRAFLKEVTEPTVGDGKMEYFNVRCSTTWLKPDQAMWYLACPSCTKKVSEVSGGNRWWCEGCSKEYDSFKRRYIVSVKVGDSSGEAWVSVFNEQAEALLGMPADQLADIKDQDEKKYEEALKGALWKEHVARLSVTVQEYMDQKRQRITVRSLQPVSWAGESKYALEQIAKLQGHPVAT
The following text describes a protein:
Function:
Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes.
Subcellular Localization:
Nucleus. Chromosome. Note=Disperses from heterochromatin at the G1/S-phase transition.
Sequence:
MKKGGVRSYRRSSTSKRSVIDDDSEPELPSMTKEAIASHKADSGSSDNEVESDHESKSSSKKLKENAKEEEGGEEEEEDEYVVEKVLKHRMARKGGGYEYLLKWEGYDDPSDNTWSSEADCSGCKQLIEAYWNEHGGRPEPSKRKRTARPKKPEAKEPSPKSRKTDEDKHDKDSNEKIEDVNEKTIKFADKSQEEFNENGPPSGQPNGHIESDNESKSPSQKESNESEDIQIAETPSNVTPKKKPSPEVPKLPDNRELTVKQVENYDSWEDLVSSIDTIERKDDGTLEIYLTWKNGAISHHPSTITNKKCPQKMLQFYESHLTFRENE
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3438 (m5C3438) in 28S rRNA. m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (By similarity). Required for corpus callosum and cerebral cortex development.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGLYAAAAAVLAGVESRQGSLKGLVYSSNFQNLKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLQESSRPGQAYQVPRFVRVNTLKTRPEDAIDYFKRQGFSYQGRASSLEDLRALKGQHFLLDPLLPELLVFPAQTDLHEHPLYRAGHLILQDKASCLPAMLLSPPPGSHVIDACAAPGNKTSYIAALLKNQGKIFAFDQDAKRLAAMATLVARAGVSCCELAEKDFLTVSPSDQRYSQVQYILLDPSCSGSGMLSRQLEEHGEGTPSKERLQALAGFQQRALCHALRFPSLQRLVYSTCSLCQEENEDVVQEALQHNSGTFRLAPVLPTWPHRGLSTFPGSEHCLRASPETTLTGGFFIAVFERAEVVPTPAPQTDAMDPEPLSQVPKRKRRRKAAVGASMQPST
The following text describes a protein:
Function:
Acts as a negative regulator of seedling photomorphogenesis.
Subcellular Localization:
Nucleus.
Sequence:
MRILCDACENAAAIIFCAADEAALCRPCDEKVHMCNKLASRHVRVGLAEPSNAPCCDICENAPAFFYCEIDGSSLCLQCDMVVHVGGKRTHGRFLLLRQRIEFPGDKPKENNTRDNLQNQRVSTNGNGEANGKIDDEMIDLNANPQRVHEPSSNNNGIDVNNENNHEPAGLVPVGPFKRESEK
The following text describes a protein:
Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLCLLFLLLGLTGLQTDDNSERLRVQFTVPEKIRSTSSGGVETHVSYIILIEGKTYTVNLMQKAFLPHNFRVYGYSGTGSMKPLEHEFQNFCYYQGYIEGYPNSMAIISTCTGLRGLLQFENVSYGIEPLEPSIGFEHMVYQIKPRDSSSSVYTEREIELREKPYKIQNVEPLPDFSQYIEMHIVVEKDLYNHMGADTTVVIQKIFQLTGLTNAIFTSLNITVILSSLELWIDENKIPVTGDANELLHRFVKWKRSYLVLRPHDMAFLLVYREKSNYIGATFQGRMCDKHYGGGVALHSSTISLESLAVIIAQLLSLSMGIPYDDINKCHCPGDVCIMNPAAVHSSGVKLFSNCSVEDFLRFISKPKSQCLQNQPRLDPTYKSAVCGNGKVEEGEQCDCGNKKACDALPDTCCVADTCRFQPGSACDTGLCCESCAFIPKGHICRGSTDECDLHEYCNGSSAACQEDVYVQDGHPCGQNQWLCISGICVDGIKQCFDIFGEGTSYAPAECFQRLNSMNDLSGNCGVTPTGFTPCTSENVRCGKLLCTYDKREVISVENASVMYSNINGKICIGLHYEYGNEDEGMMWVKDGTVCGESKICQNKQCVDSSFLNYDCNPEKCNNQGVCNNKKNCHCNPSYLPPNCEHSAPGWEGGSIDSGNFPPSEPPTGGPAFTDVGTTPLAESRYIENVYRSKPTRWPFFLFIPFFIILCVLIATLVKVYFQRKKWRTEDYTSDEQLESESEPKD
The following text describes a protein:
Function:
Catalyzes the addition of a mannose residue from GDP-D-mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)-glycerol(ManGlcAGroAc2).
Sequence:
MRYAIVTETYPPEVNGVALTVHGLETGLRARGHQVDVVRPRQAADSTPADTVLVRGASLPRYPGLKFGLPATRRLTRHWATTQPDAIYVATEGPLGWSAMRAARRLGIPVATGFHTRFDEYLPDYGAAWLQGTALRWMRRFHNQAEATLVPTRELQQFLRGSGFERVQLLARAVDSLQFDPSRRDAALRAEWGIEGEGFAAIYVGRIANEKNLPLAIRAFRKLQQLRPKARFVWVGDGPAREKIAHENPDFIFCGIQRGDALARHFASGDLFLFPSRSETFGNVTLEAMASGVATVAFDYGAAREYLRNGQTGAAVEDDAAFVQAALTLTENDDVRQRMGHAAAQAMKKLHPDNVVSDFEALLLGITAARGRYVVDAA
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Subcellular Localization:
Nucleus.
Sequence:
MPSGSINGHGREEDSSEPVAIVAFGNALLDMSISVKDDSLIQKYGLPCDAQIEVTNEQQGLFSEVIQNYPVEYVAGGSAQNTVRILCRLIKNQWPSYVIGKIAHDPAGIILQKLLAQDGVRTRYVFDEKLPTGCCVAIVRPGGTRCLAANIGAAREFNKENFVADMMDLIDRARILYVEGFFASHSPDVAMAALSRGHSRGGSTEAWDWSKLNERLAVVTCGASGVVCATRSESWLFPAEKLQPHLVKDTTGAGDAFLAGFFSQLLVGRPLDVCVATGQQTARIVITQTGCRLPV
The following text describes a protein:
Function:
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytosol.
Sequence:
MLIEAQAEQCTFVTRGLCAAAVLCQVEPVGRWFEAFIKRRNRNVSASFQELEDEKESSEESEDEEFQLEEFPLLKTLDPKDWKNQDHYAVLGLKNLRYKATQRQIKAAHKAMVLKHHPDKRKAAGEQIVEGDNDYFTCITKAYEILSDPIKRRAFNSIDPTFDNSIPSKSEGKDNFFDAFSPVFERNSRWSNKKNIPKLGDMNSCIEEVDGFYSFWYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRAARAQRKKEEMIRIRTLVDNAYSSDPRIKKFKEEEKARKEAEKKAKADARRKEQEEKERQKQAELEAVRLAKEKEEEEARQQALLIKKEKEIQKKAIKKERQRLRTSCKNWNYFSDNEAESVKMMEEIEKLCDRLELASLQSLNESLAVSSKEEGKSAVEKQIAEVNAQLKREKEQEEARMKQSTKGAENSAIGGGSGSKSWSEDDLQLLIKAVNLFPAGTNARWEVIANYMNLHSISGIKRTSKDVINKAKSLQKLDPQQKDDINKKAFDKFKKEHRVVPQSVDNAVPSERFEGPAADMSPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRSKKDCMKRYKELVEMVKAKKAAQEQVLNATKIKK