lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity). Can complement the growth defect of a yeast mutant lacking REI1. Required for leaf growth under cold temperature conditions.
Subcellular Localization:
Cytoplasm.
Sequence:
MPGLTCNACNMEFKDEEERNLHYKSDWHRYNLKRKVAGVPGVTEALFEARQSALAQEKNKSNEAPMLYTCAICAKGYRSSKAHEQHLQSRSHVLRVSQGTSINGEEDIAIIRQLPRRVQHRGSIDDDSEDEWVEVDSDEELAAEEASDSLSKLNVNESGSAEDMDDDGDADKYELDPTCCLMCDKKHKTLESCMLHMHKHHGFFIPDIEYLKDPEGLLTYLGLKVKRDFMCLYCNELCRPFSSLEAVRKHMEAKSHCKLHYGDGDDEEDAELEEFYDYSSSYVDEAGKQIVVSGETDNTVELVGGSELLITEKSENTTTSKTLGSREFMRYYRQKPRPTSQDSNQIIASLSSRYKSLGLKTVPSKEETLRMKVRKEMSKRGETMRTKIGVKSNVIRNLPNNVPY
The following text describes a protein:
Function:
Required for 60S ribosomal subunit synthesis. May be involved in assembly reactions occurring within late pre-ribosomal particles.
Miscellaneous:
MISCELLANEOUS: Present with 2170 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDSVIQKRIFVGNIFHNADDCYSELLDRFGKFGDCQDFQFEKHNHFAFIDIRFNDEADFNKLRKSFNNVKFKGNILKVDEAKPNWESTWAVQHAKDLKEDIILNAKMKKKNWQHYKKMENVAKSWKDHKEVIAGRMREAPRKRSQLRNITFRINVNGSLKVYKCYKTKLWGYERNKELNDLVYKFTNNFWKNGYNHIVDRLDYSRAVKTVRFKNGLKQLTVSKDENVCSGEMDSDENMSEEEKEKNNVILNDLLKDFDFDKPMTLNDSDEELLTEQRKGEEEEEEEEEKEVNAPEYENVNKTKDQSTLPQEKPEERKEQDEGDGQEDNEFIPTFTKEIGQGTISNTETLRNLFNPNEAEPVSQFKLIEDSDNDIDHAKDVDVNQLEEEVSKSSDTLGLTSAPVPHVSRDKDNKNFLFFPHLQSPFLVGQTQLSKVRAPGRETMLSNWDEEFWANRGNWTRDMRRKMKDALKHRKRKQSKSGLLL
The following text describes a protein:
Function:
Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA. The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC. Can complement, at least partially, the absence of the Hha protein in hha mutants.
Miscellaneous:
MISCELLANEOUS: Expression becomes maximal as cells enter the stationary phase but decreases later in the stationary phase.
Sequence:
MTVQDYLLKFRKISSLESLEKLYDHLNYTLTDDQELINMYRAADHRRAELVSGGRLFDLGQVPKSVWHYVQ
The following text describes a protein:
Function:
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity). Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The velB-VosA complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Required for full virulence on seedlings.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nuclear localization is mediated by veA (By similarity).
Sequence:
MSRSDTDGRDTSFASRNGVGGSQLSEPPSQRRERPDYGYAVEETHRPHTAQERFPDSHGQRSAPDLYSRDSDRFSYHRGDTLTPAQERSYQRELELMKARGEQERSYGGASASRSSRPLEADHHYGGMPLTRGLVDDFAPEPMASSGRPNLEGFSRVENGRRYRLVVVQHPSRARMCGFGDKDRRPLSPTLIVKLIITEEATGEEISPCEVNTSLFLLATDLCHPDDLMLAPRNILVHHHASSLSSNPIQHGGAGGYATDEFGHRSGSSLGNFAADGGGPCDDGYRSSTHPQHASESTGAAALPLSSSSMNPYDRSPHASSSIQFGGGGNFAQQSQAESYTRNLVGAAVASASVLKDEQDKWCTFFVFQDISVRTEGVYRIKLMFVNLEVSGRVGTGVADALAETYTDAFTVYSPRRFPGMLDPTPLSRKLASQGIKIPVRNDKKKQRRRNDEGGDGMGDYDGASGGDEDDE
The following text describes a protein:
Function:
Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MALTKTIQRHIYSCLSSRYGITLSIVGFILALIFSFELGELAIKWSKVQYASTFDSFYDNLAGQSYQDRICTPMPIDVVYTWVNGSDPKLIRELTAIKRQMQQEVQEMQINMFYEECPHLKNIDLSKLRNFTLLGDCAKYLPDTTVVEISHKHETASSGNSSSWCSFVNCIPSTIIVLEGSQLATDVTLLSIRELHESLSSVRWIANVTNAMYKKLSYAVDVEKVENVRFAFKSKIEMHDEQLAVSKAYLTSNKVEPLGVALERHILVTGLPIRYLMDETYLRKRIKVILKKYLRNETLPKIKAYATQGTILVELSEKYSGSKLSETKLIKFNGHLIKVYQAYLVWAPRRSISDGDDNDADPDINMASNRFSDNQELRFSIRSVERYAPWVRKIFIVTNGQIPSWLNLENPRVQIVTHEIYLTWPVPNCNEGCPPNWIRDGYCDKACNTSSCDWDGGDCLGGTEAGQATLHGIGQNAGLHQPAIISYCNLGCADSWVGDKYCDQSCDVASCGFDGGDCGTARYSMLYRVDLHNTTTSVIVPHGLEAMYINLTEVFQYATITDAEYDGKSCAIRTAVVSEKAKVLTFLFYEASKMACNDTQIKVTLVSSSDTATRKPNKTLSLTMQNFWKDNPNLKRYRPSLAPRSLSWDNITISDLDDISTSLNRSLITLKNDYNSGYLTRKGYEIRKSQLLISYVKARLDKKRNVNEPRKSKAVHSSPRRLLSYSGRGSFPWEKQRMFDSLIETKEKLEAIEQLRPKPVIGRKLLEAFKGSLQHVNRIYNKMFGYVVRKIPAHISHMMDKDILQELHDVLPQEFEKTSAHRLRSPDDMQFSFSYYYYIMGKMEELNVSKFFKDIDTDNSGVLSDRELRTLVSRILPLPVSFQALSNVEKTLINCSVALNMSTTASTEKLAKEMYFEAKLPPITLELISSCDPIVSLINESYTPTNKHKFETVDDENVAFKMLRNNVTTVMIQLDSIRRDRKKFICLNDDIDHEHENAILIKGLLIELYETLFPTPSQFELPRNYRNRFLYVKDLEEWARKKRILRMWAYTIFYIILLFTLFSFIYGRIVAYKRRYARRQRSDSSSEERLLDVYMCKLKDSNCVIKYRSCFRLNPTEQIMPDATMEAS
The following text describes a protein:
Function:
Participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria). This plastocyanin-docking protein contributes to the specific association of plastocyanin to PSI.
Miscellaneous:
MISCELLANEOUS: Plants lacking PSAF have altered thylakoid structure and are not viable.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein; Lumenal side.
Sequence:
MSLTIPANLVLNPRSNKSLTQSVPKSSARFVCSDDKSSSSTPQSMKAFSAAVALSSILLSAPMPAVADISGLTPCKDSKQFAKREKQQIKKLESSLKLYAPESAPALALNAQIEKTKRRFDNYGKYGLLCGSDGLPHLIVNGDQRHWGEFITPGILFLYIAGWIGWVGRSYLIAISGEKKPAMKEIIIDVPLASRIIFRGFIWPVAAYREFLNGDLIAKDV
The following text describes a protein:
Function:
A receptor for the FMRFamide peptides. Reacts with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. By stimulating intracellular calcium signaling through the inositol 1,4,5-trisphosphate receptor, Itpr, in dopaminergic neurons, may be involved in the maintenance of neuronal excitability and in the regulation of flight bout duration.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGTAVARLLLRLELPSPGVMPPPPTDYDYGGPISDDEFLASAMATEGPTVRYDLFPQNNSQPTLQIVLNHTEVQTDLQYPHYEDLGLDPDPNWTRICEDVYNPLLENNRIEFWVCGVLINIVGVLGILGNIISMIILSRPQMRSSINYLLTGLARCDTVLIITSILLFGIPSIYPYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVRPSRLRRSETYINIYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQRLSRSEKREIGLATMLLCVVIVFFMLNFLPLVLNISEAFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLSRDQPDLIHYESSISNNGDGTLNHRSSGRFSRHGTQRSTTTTYLVATGGPGGGGCGGGGGNNSLNNVRLTQVSGSPGLVKIKRNRAPSPGPVVYFPAREMQRSASTTNSTTNNNTSIGYDWTLPDSKKLGHVSSGF
The following text describes a protein:
Function:
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Domain:
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
Sequence:
MRIDQSIINEIKDKTDILDLVSEYVKLEKRGRNYIGLCPFHDEKTPSFTVSEDKQICHCFGCKKGGNVFQFTQEIKDISFVEAVKELGDRVNVAVDIEATQSNSNVQIASDDLQMIEMHELIQEFYYYALTKTVEGEQALTYLQERGFTDALIKERGIGFAPDSSHFCHDFLQKKGYDIELAYEAGLLSRNEENFSYYDRFRNRIMFPLKNAQGRIVGYSGRTYTGQEPKYLNSPETPIFQKRKLLYNLDKARKSIRKLDEIVLLEGFMDVIKSDTAGLKNVVATMGTQLSDEHITFIRKLTSNITLMFDGDFAGSEATLKTGQNLLQQGLNVFVIQLPSGMDPDEYIGKYGNDAFTAFVKNDKKSFAHYKVSILKDEIAHNDLSYERYLKELSHDISLMKSSILQQKALNDVAPFFNVSPEQLANEIQFNQAPANYYPEDEYGGYIEPEPIGMAQFDNLSRQEKAERAFLKHLMRDKDTFLNYYESVDKDNFTNQHFKYVFEVLHDFYAENDQYNISDAVQYVNSNELRETLISLEQYNLNDEPYENEIDDYVNVINEKGQETIESLNHKLREATRIGDVELQKYYLQQIVAKNKERM
The following text describes a protein:
Function:
Transcriptional activator involved in the unfolded protein response (UPR) pathway. Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes such as KAR2, PDI1, EUG1 and FKB2. Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway.
Miscellaneous:
MISCELLANEOUS: Present with 8970 molecules/cell in log phase SD medium; MISCELLANEOUS: [Isoform I]: Induced and active isoform; MISCELLANEOUS: [Isoform U]: Not translated. The unspliced HAC1 mRNA is stable, located in the cytoplasm, and is associated with polyribosomes, yet does not produce protein. Translational attenuation is due to basepairing of the intron with the 5'-UTR of the mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MEMTDFELTSNSQSNLAIPTNFKSTLPPRKRAKTKEEKEQRRIERILRNRRAAHQSREKKRLHLQYLERKCSLLENLLNSVNLEKLADHEDALTCSHDAFVASLDEYRDFQSTRGASLDTRASSHSSSDTFTPSPLNCTMEPATLSPKSMRDSASDQETSWELQMFKTENVPESTTLPAVDNNNLFDAVASPLADPLCDDIAGNSLPFDNSIDLDNWRNPEAQSGLNSFELNDFFITS
The following text describes a protein:
Function:
Regulates arginine biosynthesis genes.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVSRHAKILEIINSKDIDTQEELAEELKKMGMNVTQATVSRDIKELKLIKVLGNTGKYKYATINHTESYMSDKLINIFAQTVINVENIDKLIIIKAISGSAPAAAEAIDTLGFDGVAGTIAGDNTIFVMARTNEKAQEITMKLKKIITA
The following text describes a protein:
Function:
Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup. Note=Enriched at the sites of contact with apoptotic thymocyte cells. Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11.
Domain:
The EMI and EGF-like domains work in concert to promote self-assembly.
Sequence:
MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLKNVNPGKRGPVGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSNCSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVFSNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAPVKTTDFVGLAVCENPHERLRILYTKSLDVLEQIPKNAAYRKYTKQITNKKLSMVKIESDDKKLDQLQGGQLEEVIIQVENELSLARKMI
The following text describes a protein:
Function:
In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.
Subcellular Localization:
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MDRDTEAGSNDGTNDNNDTTIPPHTPESNIEAVDHVPPVPRRPSPKLSDDGASGALHVAAASRPTTQVSTIDISTLSFPDGSRGTFSTSATSATSATSATRSVASPQSSASGYTSPRTDLVETVSVASYPATLRPPGDLADLVTGEFNRRSRAWSMLRTQSSSVQPFEASRTGACDSLTGFEKEFDNIPELGEKGITDEQRLSLWKSKMKHYMILSSAGKPIWSRHGDTSLINSYMGVVQTIISFYEGAKDPLLGFTAGNARFVISTQGPLYFVAISRLGESDAQLRSQLDALYMQILSTLTLPTLKNIFVHRPSTDLRKPLEGTESLLSSLADSFTKGSPSALLGALECLRLRKSHRATINNAFLKCRSDKLLYGLIVAGGKLVSVIRPRKHSLHPSDLQLIFNMLFESGGIRAGGGENWVPLCLPAFNNRGYLYMYVSFFDSVETAEENNSNNTNNPEQPPQPPPPKPVTSPDEEIAIILISADKESFFELKSMRDKLALQLAKNGSLALIQSAARQGRPRIETILNTKPLSKEAGQGQGQGQLSHFLYKSRANVQFCQSSLSPAFETSSPPLPSSSPSENGSSQKTTEKLVSRRRLMTLYHHLHASIHAKHSHLKVLHLVSEDAASLAWITPVFEFYCVAGPNMSSGIMTQCANKVVQWAKREEERLFIIGGGVF
The following text describes a protein:
Function:
Plays a role in the flagellum-specific transport system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MKRTQRLNLTSWLTTGLLTWLLSGLLGFTSLAFAEEPLNTAIPSTAAGASSVTVTALEKEQGNAKTIALGSSSGGGGIPAFTMTTNSDGSEDYSINLQILALMTMLGFLPAMVILMTSFTRIVVVMSILRQAMGLQQTPSNQVIIGIALFLTFFIMAPVFNQINEQAVQPYLNEQITARQAFDLAQEPLKAFMLKQTRVNDLETFVEMSGAQVTAPEQVSMAVLIPAFITSELKTAFQIGFMLFLPFLIIDLVVASVLMAMGMMMLSPMIVSLPFKLMLFVLVDGWNLILSTLAGSFAL
The following text describes a protein:
Function:
Required for meiosis I segmentation. Probably acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage.
Subcellular Localization:
Nucleus.
Sequence:
MAPRKRFRLLELGSPTHSKRKVQKPLQEKTPNLRVSPLAFKIGKEIKNKEIRKTKKTESENIFNSKHVDLRLESPHPGLNFVSDAQQYSKAGDVRYLKNKSSNTLKNERQTIERPSFDNSLRFEDIEQPPKSTSTPVLSQSSQINVEREAPMFPVPYYIAPSPMYNFSPYQNFVGNPTFLTPSHNPNLNYAIPIQRPELLYPNVNVYDSPLFKKTRLPHQTKSLDKEKNYQYLPIYPVSISNNGDFVGQETPRAAPKLSKKRLSNTLDVNCSDYESSGQNATYNDSESSLN
The following text describes a protein:
Function:
Plays an essential role in chain termination during de novo fatty acid synthesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MVLTSAPPTLPMPRLLSTIPTNKSISCCVGINYGCSQSKPNSIDFQAKVFPKENVITSPKQDDKTVTPAEKIPQHLNWESRKFHWVYDTFGGKLGQEGLVFQQNFSIRSYDLGPDGKATIGCLMERLLETSVQHCRSLGLYAGGLGSTPEMTKRGLVWVLCKLQTVVEKYPSWAEVIQIDTWTGASGNNGLFRDWIVRDYSTGQILIRATGLLMLMHMKTRKFSKGTAEITDELRSALMDSDPLIDINNAKLRRLDIDARNYFQTSVAKPGWSDLDVNQHVSSAKYIDWVFKSIPFSVLETHELSSMTLEYRSECRRDSAVQSLTAVARDGTGDSTHNQGVEFDHLLRLETGSEVLRARTVWKPICDGFLSTLKIPATNGCT
The following text describes a protein:
Function:
Involved in the recombinational repair of double-strand breaks (DSB) in DNA during mitosis and meiosis. Has DNA dependent ATPase activity. Promotes D-loop (displacement loop) formation with RAD51 recombinase. Modifies the topology of double-stranded DNA during the D-loop reaction to facilitate the invasion of the homologous duplex molecule by the initiating single-stranded DNA substrate. Required for adaptation from G2/M checkpoint arrest induced by a double strand break, by participating in monitoring the extent of single-stranded DNA produced by resection of DNA ends. This role is distinct from its roles in recombination. Promotes colocalization of RAD51 and DMC1 during meiotic recombination. Involved in crossover interference.
Subcellular Localization:
Nucleus.
Sequence:
MSNGLSLPKYANMPFRPPRMAKQGDKRRGGDSTAGGETAVVREGGLGKSVKDQEQTGDGLKRPKRETKIFMVTYRKASNKKNKTWDGDGYGVLRSGEQLRVYNGDGKALGTYHWQADRAMSDVVFRCGAGWECQLDYEIKDEREFSAALDTVKGALAPEKKSPCRTTVQPGPGAGGNNTPTRVPLSKLFVGAKNTKFKPVMRSADAAIAAGSAASGRHCALFDKTQIDDPLVMNKAGDDEVEVVVDPILSKKLRQHQRTGIKFMYDCVRGLARSEKDDDRTVMILEYDSDVKGCLLADEMGLGKTCMTIALIWTLLKQHPRPSSVPCSQLGVALQGICQKVLVVCPVTLIGNWKKEFIKWLPMNRIGILTLSSKNTPEKDKNDVRNFLRVQRTYQVLILGYEKLLNVFSELDQAKSKLDLLICDEGHRLKNSSSKILKCLTDLEIERKVILTGTPIQNDLNEFYTIINFINPGILGTFAHFKRVYITPITRARDVNNKHNDQIVSLGESRSQDLIEITKKFILRRTSSIIADYLPPRTDIVVFCKPTQHQLDAFNQVLVGTRVDFQNMSFNSSLGLITLFKKICNSPSLVSSDSYFQSKVNGGTPALRIAQSTTSGKLKVLMSLLHQIAHRSDNEKVVVISNYTQTLDIIGNLMSSASLSYLRLDGSTPTKERDAIVNDFNRSQTIFGFLLSAKSGGVGLNLVGASRLILFDNDWNPSVDLQAMSRIHRDGQKKPCFIYRLVTTGCIDEKIFQRQLMKNNLSKKFLDDHCDDKSSDNVFEQEDLKDLFSVQSGTLSNTHDLLCSCEGSGEEFEDTNTPPPSSENTEGGKAKMTGWMRALDVKNIMDNSQKQQSALKATIMKKCLVGYRHINPRLMSDFGDHILERTLEEYPDSVTFAFVKRNK
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Sequence:
MTSKKFSWPKTIIALLLTLGLWLGLADLPTYALGGIQPELDQPAPLFTLPSTTGEGEVNLTDYRGQWVVLYFYPQDFTPGCTLEAQRFQRDLTKYQALNAQVIGVSVDDLDSHEAFCDAEGLKFPLLADSDGAVIKTYGSWLSGMALRHTYVIDPEGILRERFLGVRPATHSEEVLARLAELQA
The following text describes a protein:
Function:
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Subcellular Localization:
Cytoplasm.
Domain:
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Sequence:
MSGFGDVPDQYDPAGVEERVFSYWEAVDAYEQTVDHRADAETFFFVDGPPYTSGAAHMGTTWNKTLKDAYIRYHRMQGYDVTDRPGYDMHGLPIETKVEEQLGFESKKDIQEFGEEAFIEECKRFADDNLDGLQSDFQSFGVWMDWDNPYKTVDPSYMEAAWWAFSEVHDNGLVERGQRSISQCPRCETAIANNEVEYEDVTDPSIYVRFDLDDREGSLVVWTTTPWTIPANQFVAVDEDGDYQQVRATTPDGETDVLYVASECVEDVLSAGGYSDHEIVADHSGSDLIGWSYTPPLADAVPANPTDADGTHEVYHGDWVEADRTGLVHSAPGHGEEDFERGAELDLPVFCPVGEDGVYTDAGGKYAGAFVRDANDDIIADLEARDAMLASQTVEHSYGHCWRCDTGIIQIVTDQWFITITDVKDELLANMDTSEWHPEWARDNRFRDFVENAPDWNVSRQRYWGIPVPIWTPEDWSGDAEDVLVVGTREELAALADQDVDPASVDLHKPTVDDITITEDGTEYTRVPDVFDVWLDSSVASWGTLNYPEQEDDFDELWPADLIMEAHDQTRGWFWSQLGMGTAALGDVPYEEVLMHGYANMPDGRGMSKSKGITIEPNEVIDEYGADPMRMFLLSVTPQGDDMSFSWDETENMQRDLNILWNVFRFPRPYMALDDFDANVPAAFGGDDAGVGIADADLETVDEWLLSRLQHVKADATAHWEDFEQHRALDAVLEFVVEDLSRYYVQVVRERMWEDDASASKTAAYATMQRVLLEVVALLAPYAPFVTEELYSHLTGDRGYDTVHMADWPTVEESLRAPALEADVAVLRAAEEAGSHARQQAGRKLRWPVTRVVVDAAEDSVVDALDAHGDLLADRLNTRAIEVVEPGAAWDELAYSARADMSELGPAFGDDAGAVMNALNDARVTDRDIDALAEQVAADLGRDDIELTTEMVEFVEETPEHVAGAAFETETAAGTVYVDTELNEDVESEGYAREVVRRVQEMRKEMDLAMDAEIRLDVLVFDERVGELVARHEPLITAETRARELGEVEDGHREEWDVEGTTMILEVEAV
The following text describes a protein:
Function:
Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
Sequence:
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHESKKVQLVLSGEELLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEYKPNPVEEGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDDEAAKASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVPLKNNRYRISKSRYDSIDSYLSECGEKYNDIDLTKDEEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMIAAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKATGSAEQAAVAAAAEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLLLKCNQIANELCECPELLGPAFRKVKYSGSKIDASS
The following text describes a protein:
Function:
Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs). Does not bind nucleic acids. May participate in antigen presentation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The cytoplasmic tail appears to be dispensable for TLR7-mediated signaling.
Sequence:
MAWRYSQLLLVPVQLVFLASVCCPGVWGSTVSEELHRMVGQSLSVQCQYKPKEESYVLKTWCRQTAPSKCTRVVTTSEPRKAARELQHTIWDDPEAGFFNITMTQLTEDDSAFYWCGPYYPSLREVTVLRNISLVVSPAPSTLPSQTIAPLPESTATIFMPFPVLTTSPEETTDSSINGTGHRNQSSSSPGWTSPGLLVSVQYGLLLLKALMLSVFCVLLCWRSGQGREYMAETMELSKLPHISKSLDTVSHISGYEKKANWY
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MNLDSAADFCPQCHFMLELPEVMDIMECNRCGYKCSITDYQPKYIISTIKMEPKSWLSNQQDSKLSDQSHRAQEAYFSTAQLRSADEGSTVFYECVKCQFRYQLNN