lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cytokinesis.
Subcellular Localization:
Cell tip. Note=Also at the division site.
Sequence:
MSIPKQLPCMVRALYAWPGEREGDLKFTEGDLIECLSIGDGKWWIGRHINTNTQGIFPSNFVHCLDIPTVRPGSSMSRTSASSFRYSSPQKSSIDTPITSSDQGLTPDLVGSSNALNKPTRESDSLKHQKSHPMLNSLGSSLSLKKSVSRPPSSMSRTNLDVSSRWDNTADNDSQIDAQDLSRSTPSPLRSAMENVLQSLNAMGKKSFSRANSPLLRLTKSTTTSKETDFIPVPPAHGSTSMTSRSKLDDSTDNSSKPRTSLQPGESPMKSSRDISRKPSMASSVLSPSDYFPQHRRFQSAPAPIPRPVSTLIPLTQVRTTASNVIKPRPQTTERPSTAQSFRKGGGFLKKTFKKLLRRGSSKRKPSLQPTPPVSYPAHNVPQKGVRPASPHTLKSVKDDLKRTKTYTKAEFAAKREEIFNKLSMPVYEPLKDLSECIGNVLADGEPVQFSVGTNIHNMNFSAIDKQIRSIIPQRVQVSPAVLAKNYLAPGQTTALAQMRAVFIYISERITFTNQTLDNDELRTSTQVISEGQGTPFEVALLVKEMLQALDLWCEVIEGYLKSPDDIYYTRDININHAWNVVTFDNEVRLIDASFASPTHPQQALKSSSSNDFYFLMKPNECIFTHVPENPDQQFIMPDLSMPIVMALPWVSSVYFTLGLKLRKFNTSILHLNDLEVLQIEFLAPKDIECVAEVDALSALAPTADVSQCYKYTLTQAFWETPDIRVMRVKAVMPANNRAAVLRIYAGRLGVSSPVRTAPHPMAMSLPFVHHGKNKALEFVTRHPVPHCPSVDLYINSPQCGTLHSGVEYKFNVSAYACQPSTSISNTRLAIQTPTGNIVRLREERSGNGVIFFSLSLTINETGEYRALILAEKIGRWVVYATWQAV
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MDRGKNKDTHTFAKMATSDIVGFYRDRSVFITGATGFMGKVLVEKLLRCCPGVKTLYLLMRPKAGNDIRTRLEELISTKVFDNLRRDSPELMNKLVPIAGDMSLPSLGVSATDIKMLSDNVSIVFHSAATVKFDEALKSAVEMNLKGTMRLIELVRKLERLDALVHVSTAYANCDKDEIAEMIYPPPADPHKLMECVDWMDEELLKGITKKLIGKRPNTYTYTKALAEHLLMEECGGIPLAIVRPTIVTAAMKEPIPGWVDNLNGPTGLIAGAGKGLLRTLWCHTTMVADVIPVEFPINLMIAVAWHTATHKPNNIIVYNCASGYHNPLTWGEIERQGRVALLKYPMSDVLWYPSGSFKSNLTLHKIDVVLYHYLPAYFLDFLARMSGNPAMLVRLYDKAHRAMSCLNYFTTHEWRFISENPIQLLEKMSPEDRRVFYFDVRTIDWPSYIETYALGTRRFILKDDPSTLPAARRHMTRMFWIQQISRVAILLLFWRAVVSRSETARRVWNLAFTMLVSMMRRMSAGAGIGIAKRREKKDEEKSRDMSKASVDVNNSSTPSKAVSMSIAPIK
The following text describes a protein:
Function:
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Subcellular Localization:
Secreted. Golgi apparatus. Endoplasmic reticulum.
Sequence:
ESWEVDLDIKEVIVRPNYTKSTSDNDIALLHLAKPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDETKKNRTSILNFIKIPVVSYNACVHAMENKVSENMLCAGILGNPRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGCGRLNNYGI
The following text describes a protein:
Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MGNENSTSDHQRTSSVQSPRSLQPPGKSQSLQKQQGDLPGSCAGSIPGTDDVIQPAAPVDPGHPPLAGIGSNQGEVCTSLQLSYTIVTVQSASPSAARASPAPLAPEHTASAPSAAGPGVEVTPTGSPQHLAKNEPRSSDSEEAFETPESTTPVKAPPAPPPPPPEVTPEPEVIDPPAPEEPGCISEPPVVVPDGPRSSESVEGSPFRPSHSSSAVFDEDKPIASSGTYNLDFDSIELVDNFQSLEPCSADSKGQECKVSTRRKSTESVPPSKSTLSRSLSLQASDFDGASCPGSPEAGTLTTDACGTGSNSASSTLKRTKKTRPPSLKKKQATKKPTETPPVKETQQEPGEESPVPSEEHLAPETKTESATPEGAGCTLSDDTPLESPAVPTATCPLTLESAEDVSPLVSGGGRVQNSPPVGRKSVPLTTASEAVEVTLSDSGGQEDLPAKGLSVRLEFDYSEDKGSWESQQENAPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPTEPSDTPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLSQQSYNFDPDACEESLDPFKASSKTPSSPSKSPASFEIPASTTEADGDGLNKPAKKKKTPLKTMVEDVMSVCSLFDTFRVKKSPKRSPLSDPPSQDPTPAATPEAPSAISTVVHATDEEKLAVTSQKWTCMTVDLDADKQDFPQPSDLSNFVNETKFNSPSEELDYRNSYEIEYMEKLGSSLPQDDDTPKKQALYLMFDTPQESPVKSPPVRMSDSPTPCSGSSFEDTEALVNAATKLQHPVARGLPSSQEPLLQVPEKPSQKELEAMALGTPAEAIEITAPEGAFASADTLLSRLAHPASLCGALGYLEPDLAEKNPPVFAQKLQEELEFAVMRIEALKLARQIALASRSRQDTKREAAHPPDVSISKTALYSRIGSTEVEKPPGLLFQQPDLDSALQVARAEVIAKEREVSEWRDKYEESRREVVEMRKIVAEYEKTIAQMIPGTERKILSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKKCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAYQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS
The following text describes a protein:
Function:
Plays an essential role in virion assembly and morphogenesis. Also plays a role in the inhibition of host immune response by dysregulating mTOR. Sequesters host RICTOR and RPTOR, thereby disrupting mTORC1 and mTORC2 crosstalk. In turn, blocks the host antiviral response in part through mTOR-dependent degradation of cGAS, the primary poxvirus sensor.
Miscellaneous:
MISCELLANEOUS: Originally annotated as the product of the F18R open reading frame (protein F18), it is now referred as protein F17 since there are only 17 open reading frames in the HindIII fragment.
Subcellular Localization:
Virion. Note=Major component of the virion comprising about 10% of the virion mass.
Sequence:
MNSHFASAHTPFYINTKEGRYLVLKAVKVCDVRTVECEGSKASCVLKVDKPSSPACERRPSSPSRCERMNNPRKQVPFMRTDMLQNMFAANRDNVASRLLN
The following text describes a protein:
Function:
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MIRTTTRTTRIGIRIRGRIKEHDLRKFHSSVSTASSEHSTPINLSNFTPDLIRSFSIIAHIDHGKSTLSDRLLELTRTIPQQPIPSTSSSSGHSNPNQAPTRNQQVLDQLAVERERGITVKAVAVSMFYTSPSGITYLLNLIDTPGHVDFTTEVLRSLSATQGAILLVDATQGVQAQTLAVLQAARRRRLTILPVLNKLDLPSAEPEKVALQVGRLVTNEGSAPGEIIKISAKTGLGVEHLLEALVNKLPPPVADPNRPLRAFVFDSWFDHFQGVVSLVSIADGKIQKGDKIKSFKTGKTFQVADCGIMHPHQLSLPSGLHAGQCGWLTCAMKNAKEAILGDTFYAAKTPLTEIEPVNQSIETRQSMVFAGLYPIDSNAFDRLADAIQRLVLNDRSVTVNKESSVALGQGFRLGFLGTLHMDVFRQRLNDEYASEVIITRPFVPLQLISKGKTSMIEKPVDFPNVRNRADGVKVFERIIDGTIIVPDRFTGPVMELCSSHRGIQQTFEYIAAPSSEASKKGGEVVLEGDERWVEIRYKIPLSEIVTTFHSTLKSLSSGYATFDYETPEGHEGFVEADLVRVDIVVNKSSPIDAFATVVHRDHALREARAVLARLKSVIPRQQFEIALQATIGSKIIASERITAVRKDVTAGLYGGHYERKMKHLQKQKEGKKKLRSLSIGKVEIPQEAFSAVLSVDGKVSSTVAGNKRK
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAKTIDFLASDGEDNFAARTISATSKPNRNDATASSSKPQKRARRSTKGSDDDGNDDFDIASSLLASAAEPAAVGMLSSSQQASQKAYASRVSAKDDDDDDARFIASVMQHANIKAGLEVAKKALSGKNKGKNKLGSGVVTGGGSFQSMGLHPSLLRSLLIRGFTTPTPIQRQAIPAIMSQPPRDVVGMARTGSGKTLAYLIPLINRLNGRHSPTFGIKSLILCPSRELAVQILRVGKEIARGWKADAGEGQDSRGEAIRWAIIVGGESLDEQFGIMSNNPDVVIATPGRMLHLTVEMNLDLKSVEYVVFDEADRLFEMGFAEQLEEMLLRLPPTRQTLLFSATLPKKLVEFTKAGLQANPKLVRLDADSKISADLRMAFFSVKPSEKEAALLVLLRDVIGVPLGEQAARDLDEEAQFNEDASDNQADGQRSRGYGNRRAEFKGKTKDKHLGNKRKRGGPGGALELLPHQTIIFCATKHHVEYLLLLLTTTGYACSHIYSSLDQATRGIQMSRFRRGQNSLLIVTDVAARGIDLPVLEHVVNFDFPPQPRTFVHRVGRTARAGRNGWAWSMCTNAELPYLCDLQLFLARPLVSSHTAIAALANGRDVASADALGLHDSLILGTLPREALDLETEFISSSLTNTSSSTAHDFPALRAVADRAQQKYEKSIAKASQESHRRAKEMVKLGSIEQINIRTASGREGQVPEWTLAGSPLEEMAVHDVVKRPEVYGLNRANKADAVTSALGSDRMDDKVKRGTDNALKEADEAAKRAALLAKVNAFRPQETVFEIGIRGDATPLGALMRSRRQTMQVKTKRAEALEARKRAIEGGGDAMEDDEEVTKPKVAARNKGKKKATAGKADNDEAVVGDAMVDMEQADEADILAAFDTTKPSKAQVQREALTDSETDASESDRDAASARHTKRARTKKAAPTSYRDPNFYLSYEQQGSTSERGYSLNNARSHTDSFIQQASAVSFDLAGDDATLGTQSQRPNVTRWDSKKKNFIQATVGADNKKMIRTESGVRLPASFRSGRYEDWKREKRIDMPKTGEIESNNHRVHERSPPETSVMGLKRFRHTKLSAPKTAGVFGNRRPGQPKRQAAKDEVKSARQIQKDRELKEKRREKNARPSKSDTNRRAKRGAARRGRGGHGPRGASR
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MCLSLSSPAMASEEPMDAPPAPNLLSETLSAAELVADLGGDYALFPPGGGSTEFRQLDDDVSSSLWSSALVSNSRVSAVAPESWIAPQGNWLLPENEGSDNAESASEVVPSKMGAGLVNLGNTCFLNAILQCFTHTVPLVQGLRSSTHPIPCSGHKDGFCVICALRIHVERSLAASGGTFSPLEFVNNLKYFSSDFRRYQQEDAHEFMQCTLDKLERCFLGLKKSNLNFEDVNLVEKVFGGRLISKLQCSTCDHTSNTFEPLIDMSLEIDNVDSLPSALESFTKVENIDDNLQCDNCKEEVSMEKQLMLDQTPSVAAFHLKRFKTDGILVEKIDKHIDFPLELDLQPYTIKVMEDPGAENDVPLKYDLYAIVVHTGLSSTSGHYFCFVRSAPDTWHKLDDSMVTEVSVETVLSQEAYILFYARQGTPWFLSIMEEKTQCLNPNIMSTSPKSVLDVGDNMSKSNPILLPNIERSVAEESKEYSEPQFDYYCQEDHGFLEINDTEDVTHGSGQLLSGSNQEIFYSNTSKDVDAQKLFSSRGGHKVATHGCGQLLSGLNQESVGLNSSKNVDAQQLFRNWTTLDDSAMFDIGNSYIENGSLDNDNTFQEAVDFLEKAGFHSLTLPSLPPDDAPDKFHISCDNLKRENHRSCKRSSNKLTGDSEERREAVKYLCKNRSRRGALLKFVTPNKVLDKKRKNMDSLQCKKSTKKPSHTSVTPPVAAGSSR
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is YafQ (By similarity).
Sequence:
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEASENYSAEEFTKRILNGGQ
The following text describes a protein:
Function:
Probable transcriptional regulator (By similarity). Required for nucleolar dominance that consist in the silencing of rRNA genes inherited from one progenitor in genetic hybrids.
Subcellular Localization:
Nucleus.
Domain:
The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.
Sequence:
MENTDELVSIELPAPASWKKLFYPKRAGTPRKTEIVFVAPTGEEISSRKQLEQYLKAHPGNPVISEFEWTTGETPRRSSRISQKVKATTPTPDKEPLLKKRRSSLTKKDNKEAAEKNEEAAVKENMDVDKDGKTENAEAEKEKEKEGVTEIAEAEKENNEGEKTEAEKVNKEGEKTEAGKEGQTEIAEAEKEKEGEKAEAENKEAEVVRDKKESMEVDTSELEKKAGSGEGAEEPSKVEGLKDTEMKEAQEVVTEADVEKKPAEEKTENKGSVTTEANGEQNVTLGEPNLDADAEADKGKESKEYDEKTTEAEANKENDTQESDEKKTEAAANKENETQESDVKKTEAAVAEEKSNDMKAEDTNRSLEANQVQQQQGAAASVSC
The following text describes a protein:
Function:
Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron.
Sequence:
MGMEAKPTPAAISEDESALVQKITKLATAIGDLPSLHPSPEVNSLFTELVTACIPPSTIDVDTLGPEAQSMRRRLITLCADAEGHLESHYSDLLAAHDGDPLDHLEIFPYFGNYVKLSQLEHGLLSRHVSESFSRVAFLGSGPLPLSSLVLAARHLPDAAFVNYDISPDANARASRLVHADADADAGIGIGARMEFRTADVTDEAVAGEMGRYDVVFLAALVGMAAEEKARVVAHLGRHMAPGAALVVRSAHGARGFLYPVVDPEDVRKGGFEVLCVHHPEDEVINSVIIAQKKMLEVDDEGCVRAENGSGIKGCAAAASENGSGMKGCAAAANGDVLCAAAAAVVSRPCLGCCEMEARAHRKLEEMAMDQELPS
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli.
Sequence:
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
RAEPSEGEGLQPGSPEAETPTDARPPTRHVTSGGAPAPSRTSHPPLRAPYLSPASRFPASRDPAAQRFVRPEEVRPEEARPGTLFSGSPLPAGRFCRCASLSIPVRAREGGKEGAASGARGRLGAGRPPFRLTPSTYSRRSRAAATSKMSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTILRTMRNFSSMNIAASILLFVAAIAAAIIANSPVAPVYQEFLLHELHLQIGNFNLLSHGGENLRMIEFINDGLMTIFFLLVGLEIKRELLVGELSSFRKAALPFIAACGGMLFPVIVYMSICPPGSAGSQGLAIPMATDIAFSLGVLSLLGSRVPLSLKIFLTAFAVVDDIGGILVIALFYSSHVSYGYILIAALLYVLLYFIGKRGTTNKIFFLVIGVVIWYLFLQSGIHSTISGVILAFVIPAKPRLDVGKYIEHIRHTIAGFPVVESGSIVLTNEQIAKLKEVESASDRVISPLQSLEDNLHGAVNYLILPLFAFVNAGVVFSGGGELVGSVGMAVAAGLLFGKFAGIYFFTWLAIKIKLTPMPPGMTWKNLSGIALLGGIGFTVSLFIANLSFGANYPVLLNQAKFGVLSGTILSGLLGYIVLRIVLPVRKRK
The following text describes a protein:
Function:
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
Subcellular Localization:
Vacuole.
Sequence:
MSILTLLVKIAGLLGTITVGANAVSYSRFRRRNLRNFRSPIDESKEVLADFTSQEHNEGKFFFGLATAPAHAEDDLDDAWIRFAKETPCSAEDEEDKKAKRKKKVKLAVGAITKGLAKNTQGKEDNTVADSTPTKNVAAWHNTPHAEVRLKFWSDPDQEVKLAKDTGVTVFRMGVDWCRIMPKEPTKGIEEAVDYEALEHYKWILNRVRSNGMKVMLTLFHHSLPPWAADYGGWKMEKTVDYFMDFTRLVVDSMFDLVDSWITFNEPHVFAMLTYMAGTWPGNTPDFLEMATSTLPMGVFHRVMHWMAVAHSKAYDYIHAKTSLEKPLVGVAHHVSFMRPYGLFDVGSVTFSNSLTMFSYIDSICEKLDFIGINYYGQEAVCGVGLKLVETDEYSESGRGVYPDGLYRVLLMFHQRYKHLNVPFIVTENGVSDETDVIRRPYMIEHLLALYAAMLKGVPVLGYIFWTISDNWEWADGYGPKFGLVAVDRANNLARTVRPSYHLFTKIVKSGKITRNDRSLAWEELQKAAKAGKVRPFYRAVDNHGLMYADGLDKPQGRQFVDRDWRFGHYQVDGLQDPLSRLARALLIWPAITKKKIRKVKVKHTDESGLALQPA
The following text describes a protein:
Function:
Probable transcription factor that may function in the maintenance of the proper function of the central cell in pollen tube attraction.
Subcellular Localization:
Nucleus.
Sequence:
MTMRSSSPSSSSSYSLAFTSLSNRLETIFKKASELCTLCDIEACVIYYGPDGELKTWPKEKEKVRDIALRYSLLNEALRRKKSVNLHGFLNKKKNKGLKNPNKKMKTSLKNVNILKYPLADHYPPDQVSPLIQSLELHVSKFQERLRFLESQKQNQTKPDHQSLTPSSLNHYTQSLNPSQFSLFMYNHGDNTLSQIPVSASNFNQDYFSALLEESELKNQLMKPEICGYDQNQNMSMGDITNNKFQDPCVSNKEAVQESVNNFGLNQLMYKEFYGCDQNMSMGNINSNSFQNPCVSNTQHYSAVEESVKNPWLNQLMQNELYGYGYAGFC
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MASDERVVRRQIGRKGSMARTWLLMGSEGQRQMVEASRQLIMQRTGLTARDFRILDPMLSYSSTIVGRDRAIVLNLEQIKAIITAHEVLLLNSRDPSVIPFVDELHAQILHHHTTVTDHPQPQDKGEMRQDSSRKKILPFEFVVLEACLEAVISSLENEANILELEALPALDKLTSKISTLNLERVRHIKSRLVALTARVQRVRDELENLLDDDGDMAELYLTDKLAQKKFENSSTFSSMNNNGDDMMMNRVLQPNIVDRTGHEISLERGGDSTCDHGDYENVVGEEISGTQAGTVYSGVTNVSELEMLLGAYFVQIGGTVNKISALSDYVEDTEDYINITLDDNQNRILQTGVQIGTASVILNCFVAVTGVFGMNIHIQLFDDGGMKEFLGTIFGCTGACVILYFLAMLWYKKMRMLE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase (By similarity). Functions in the OLL neurons in the anterior ganglion to inhibit avoidance to microbial pathogens such as P.aeruginosa although worms do display avoidance behavior, vacating a P.aeruginosa lawn within 24 hours. Likely to act by inhibiting the neuropeptide receptor npr-1.
Subcellular Localization:
Cytoplasm.
Sequence:
MGDEFPFHHLGYVCLNEIYKHLTLKEIFQLSFSSNQIKRSLGIASIPVKSIFVNFDSQYPKIKLIGESSQLEWVFGIPDGLEYTDVGVYKIGHFKFQCKTSGTAFYTEHYDLENAMLVVIRYMISIFKCSNSIITYLSIDLGVIEDSRAICENFVAFKKVERLSIFQTNYGVERNTLNFAQSFDWICDNLEIKNIHIGADVLEPKMVQKTNGEFDIKLCARRFEQVLTMDHIYLQHADWITSEDLLNLDVQTAMLIENNLTEQDLNAFIKQWLRSDSDKLWWLEVKGKMMFNREEVLKDLDVQDDAYRSLNTRWYVARRSRANPSGNGCARKKMGSLRPKLTELWPFKVYIIFGSILIVFGPAALNRMITLRRMDVETDRPSGSETGIFVSKSAVYPFGNKNEVVKVWWNIDKPENCLDWIGLFDNNDSSFYLDQKSLRQHISPVVFTLTSKNLLNASEVYFGLIDGMTGRLLAKSENVEICKSASLVVHEVKKPENINVYLNTNHGRIEIPKKRSFSRKNGSFRSSFEFDFDVEDLHISLVENSEKLNFDHFIASNQLQNNYIQSKSFSHSHVVEIVFSIEPKTSKKSAPDIMEIASSSQTPPESHWKTYLDAKKRKFYVNHVTKETRWTKPDTLNNNHIEPETPVHKRLSDRSASPRNSFITPRRTITVRSAGCPKSDLIQFFQRDEFKTALYENQDAMQIYNECSVVRHAIHRIQKDLDPPSKFENQPLFVRFVNLFADITQPLPSGWECITMNNRTVFLNHANKETSFYDPRIRRFETKTSRRGRSVPSRSSTAHKGKIDHALISKCEDLRKIAQDNFPQIAERISKKLMLIERFGGLAVASLANDLDITLALSMLDSNTEKLAGEGDNIKMFYEDMKKEKLGKGPSRLCWKVSRDRLLDDAFRIILNVDPFVLKKSRLHIRFEGELALDYGGLSREFFILLSRELFHPKNGYFEYEGNDYHLQLRPRGCETEKEKKWLILCGRVLALAVIHRCYIDVFFTNVFYKSLQKRPVTLMDFKESDAEFYKSMNWLLENDVVDLEMSFVYSSMVNGKLAEQELVPGGESQMVTEANKAEFIDLMCQKKAIRGVEKPLEILLTSFNQILNDNLLNSLESSDLKRILSGSLELDLNDWRTNTIYKGGYSDCHIVVEWFWEVIETMTNQERFDLLLFVTGSSSVPFEGFSALRGNEEISKFCIEKWGDATSFPRAHTCFNRLQLPSYNTKQQLKSKLQQAIVNGMSYSIE
The following text describes a protein:
Function:
Effector that interacts with Rab GTPases in their active form (GTP-bound) including RAB15, RAB3A-D and RAB34. Controls downstream signaling such as cell proliferation and cell migration. Also regulates transferrin receptor recycling from the endocytic recycling compartment.
Subcellular Localization:
Early endosome membrane. Note=Colocalizes with RAB11 and RAB15 to the endocytic recycling compartment.
Sequence:
MGQKASQQLALKDSKEVPVVCEVVSEAIVHAAQKLKEYLGFEYPPSKLCPAANTLNEIFLIHFITFCQEKGVDEWLTTTKMTKHQAFLFGADWIWTFWGSNKQIKLQLAVQTLQMSSPPPVESKPCDLSNPESRVEESSWKKSRFDKLEEFCNLIGEDCLGLFIIFGMPGKPKDIRGVVLDSVKSQMVRSHLPGGKAVAQFVLETEDCVFIKELLRNCLSKKDGLREVGKVYISIL
The following text describes a protein:
Function:
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MLLAQINRDSQGMTEFPGGGMEAQHVTLCLTEAVTVADGDNLENMEGVSLQAVTLADGSTAYIQHNSKDGRLIDGQVIQLEDGSAAYVQHVPIPKSTGDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSSLQAVQLEDGTTAYIHHAVQVPQSDTILAIQADGTVAGLHTGDATIDPDTISALEQYAAKVSIDGSDGVTSTGMIGENEQEKKMQIVLQGHATRVTPKSQQSGEKAFRCKYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHSGCGKAFATGYGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPIEGCGRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGDDVLKGSQITYVTGVDGEDIVSTQVATVTQSGLSQQVTLISQDGTQHVNISQADMQAIGNTITMVTQDGTPITVPTHDAVISSAGTHSVAMVTAEGTEGQQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTETRPLTLVATSNGTQIAVQLGEQPSLEEAIRIASRIQQGETPGLDD
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MEISDKEILNEIITCNELRKEWNFDEIGIICIGYDEFIKKYPTNEIQNKVIYIHKNSIGLFFELIGQTYRVAMKNIREYPLECSTICLMINGDCSIAWNKRFELKINEISEMRFTECLSKRFKKGFLIYYYREMIYSKRNRLLKQEESKYEFNFITKAIAKYSRGYHLYKHLLWLIDHSHINHIYLDIMKWCEEGIINDSSDYSLMNIRKKVIETYYCIKLVNGSYTIKLNEINQQIKDFFILEYVWVSTLIHLNPQHESLWLYHYTISQLIKCIEPKLTKESKQQFNFTNYIKLIYEQKGCIKVSREFTELNISFINQYSFIPINSIEFQFLNYEKNRVSNQKVMRLVERRLTSNLD
The following text describes a protein:
Function:
Component of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Binding by the elongator complex stabilizes microtubules and promotes their growth. This induces central spindle asymmetry, promoting polarized signaling endosome trafficking during asymmetric cell division and cell fate assignation of sensory organ precursor cells.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During asymmetric cell division of sensory organ precursor cells the elongator complex preferentially binds and stabilizes microtubules on the anterior side (pIIb daughter cell) of the spindle.
Sequence:
MLSNLVVTKQKVVLVIDELNRERIAPKFIGSLLHEQGQGADTIKALPTGVSLKHVATFEALIDKYANNNTGSTTDSNSTGFNVILPTLADLLCYQTPAFIFGFLNRLRRSDNVRRVFLWASPQHLQDPHADYILAGCEYLAELVLRLESDKLLSLISRKPGGGVSNRRYSCEVSKTQFKVTPLDGGLPAGASPKQPSPEAEQTTEPASSTFKIELDEDEVLARNALTLPYERTSEPSEGNIIYTPDADDDFDEEDPDEDLCI
The following text describes a protein:
Function:
Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Subcellular Localization:
Nucleus.
Sequence:
MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR
The following text describes a protein:
Function:
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEGEQSPQGEKSLQRKQFVRPPLDLWQDLKDGVRYVIFDCRANLIVMPLLILFESMLCKIIIKKVAYTEIDYKAYMEQIEMIQLDGMLDYSQVSGGTGPLVYPAGHVLIYKMMYWLTEGMDHVERGQVFFRYLYLLTLALQMACYYLLHLPPWCVVLACLSKRLHSIYVLRLFNDCFTTLFMVVTVLGAIVASRCHQRPKLKKSLALVISATYSMAVSIKMNALLYFPAMMISLFILNDANVILTLLDLVAMIAWQVAVAVPFLRSFPQQYLHCAFNFGRKFMYQWSINWQMMDEEAFNDKRFHLALLISHLIALTTLFVTRYPRILPDLWSSLCHPLRKNAVLNANPAKTIPFVLIASNFIGVLFSRSLHYQFLSWYHWTLPILIFWSGMPFFVGPIWYVLHEWCWNSYPPNSQASTLLLALNTVLLLLLALTQLSGSVALAKSHLRTTSSMEKKLN
The following text describes a protein:
Function:
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers. Required for normal cell growth, plant development, cell organ expansion and flowering. Essential for root-knot nematode infection.
Miscellaneous:
MISCELLANEOUS: Plants silencing ADF2 show net stabilization of F-actin that blocks cell maturation and root-knot nematode development and reproduction.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MANAASGMAVHDDCKLKFMELKAKRTFRTIVYKIEDKQVIVEKLGEPEQSYDDFAASLPADDCRYCIYDFDFVTAENCQKSKIFFIAWSPDTAKVRDKMIYASSKDRFKRELDGIQVELQATDPTEMGLDVFKSRTN
The following text describes a protein:
Function:
Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow. Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKNFFVLFLIHGSLCNGNLLSINPENLETWKGSCVLIPCQINETLHFAYLPHASVAWYFRPSLADALFDYNVQPLFDSSKTLEDHVNLTSPNFQGRVRFVGDLTKRDCSLMITELHMNDSGTYNAKVAILGENNERLHLLFQSAKIHVRETPPEPKVETQRIQTPGLWAMKVICSVSYHCPNEPMMLTLRGLEKHPQKRNIGNRTIQTIVSFEPTWEEESKKVICLLTNKDGSHKSKTTLQLDVKHSPLGVQLVLLNDLPIKEGDNVRLNCSVSRSLPNDNWYNWAKSDSHTVELRYSGPKLLTFPASPGPATSYKCEACNWLGCTSSQAVTVDVHFAPKDVNIWKGAPEYIIEGSVVQLRCQVGMANPRNFAYTWYHDGQQLNATDEMLIFPDIAFAQFGNYWCEVSNSVGTNISPRVLLDVICDQCYKTPLSIRLNSRASWKGSCVWIPCYINEAPHTVISISVLWYFEPDILEDYYDHLLYDSSKTPMNQMNLTSPRFQGRVHFIGNVTLANCSLMITQLQTKDSGTYHARVLASIPDYPWPLKRFMIAPVNVTETLPEPKMETVPVEIEERKTAKVICSAPYHCPEENMTLTLSGLEEDRLSSQDTTIENGVIRTVLNFEPSFGDHGKVLKCLLKSETGSQRSRNTMKLDVQFAPRSVIALPETKDVVMMGQSLQLRCEVGKANPQEVTYAWYKKEQELVAEGALLIISKASRKHSGIYHCNATNKMGSSRSSQIELSYFCSSSQPKDCYLKVWSQ