lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Postsynaptic cell membrane; Single-pass membrane protein.
Sequence:
MVLKEIPTENITRPLGRNEVIGLLFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMRQIGVQNVKLSEYEMSIAAHLVDPLTMQITWHDIAGLDEVITELKDTVILPIQKRHLFEGSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGFRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDYNCQVIIMGATNRPQDLDSAILRRMPTRFHINQPNVRQRKDILKLILENENVESAVELSEIAKQTDGFSGSDLREMCRDAALLCVRDFVHQESPEEDFIRPIRQEDLQRAIEKMKKSKSAGVHEAFMQVPLD
The following text describes a protein:
Function:
Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Note=Outer membrane-anchored.
Sequence:
MFGLPQQEVSEEEKRAHQEQTEKTLKQAAYVAAFLWVSPMIWHLVKKQWK
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDTLIGLRGNNFVVLAADTYSINSIIKLKNDDNTKFYDIHGNKCLLLGGSIGDRLQFGEFIRKNVHLYQYQNNTDMFVKSFAFFTRKNLAYYLRRNPFEVNCLIAGYDKKDGYQLYWCDYLSNMDSVNKGAHGYGAYLVSAILDKYYHENLTVDEALDIFKLCFEELKKRFLLTQINYELRIMYDNKVETQYVTV
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
MEFSVSDWLRADQAAGPNAPHVAMSMPHQVFCWSRQSEAEGGQYLYGDAGALRTLRPDVDTGLAGADLNVGYPEAWVRKSDPDDAVPVEVIVYGAQYGGVPMDRTSVVTFRNNLNKLLLTPLQPKDPWVIDAVWCGSCLYLDIVKRPGQQQHTPGTDPDRFTYYGYKFEALATEAPDQQSGGVVDSTGEFAIMVQMRLGRHCVTMAAETDAWDPPPPGLAVPEDGSADYVGYVELKTFVIPLGERAHERLLRDKYPRWWLQSYLAGVPTLVLGGRDRGGVITEVSRLPVTRLPAMAAEAGVPFDAARMLRFGDAALDRMCEAAASRPGEHWRFEYDPARCVITGAVVPEGKLPERVMLALSGGGGDGGDGGGGEVEAGGAGGEEGGGEEGDGQHEGQHEGGGGGEYDEDEGY
The following text describes a protein:
Function:
Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel-dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria.
Sequence:
MSTKDLFAEPNLKQITVWARGVVMNKDARDIVVALTEAAAKEGKYVQAWENYVDLPDRIYVPVRAYARISSDPIESKYIYENETPDIVVLVEESLIKGVPILKGIRPGSTLVVNTKRSIDTILEFLGDTGNLAQIVTVDANSMAEAVMTLSGAEGATDATGIGAGIAAPIAGAVVKATGIVDVENLAAVVKNPAAMRRGYAEAQVRQLPPHEAVEEAAVSATELLRQMPFAGTVPSPVTENEGMVTGNWRIQRPIIDREACTECYTCWIYCPDSCITRTEEGPVFNMKYCKGCGLCTAVCPSGALTNVPELDFKD
The following text describes a protein:
Function:
Probable phosphatase.
Sequence:
MPSLKMKMKSTMGCLREKNGLHVCQRSSKIFKNSSLQAKSFQEEYQLESFTSNKKDDCVCSEATAQDLRSDETSCCEFFDEESIQDHTKANCSSTVETIFSPIPQSTDNNSEATPSCDGGSEKDLVAPSLEDKDSDSINKNSCEYQSCNVSDFFISDMIVSSSPVDEPTCLPDYGCDESSIFLDDEYMVLTFLADSNDCDDRIKNSSEPIMASEESNLYLAIHQLTSCNQEPDVNNYPDWDPAECLDPQMFIKLPDLSEVETNLSPWKRKSVTLVLDLDETLVHSSLEHCDDADFSFTVFVDFKEHTVYVKRRPYLKEFLERVSEMFQVVVFTASQSIYANQLLDILDPDGKIISRRAYRESCIFADGSYTKDLTVLGVDLAKVAIIDNCPQVFRLQVNNGIPIKSWFNDPSDCALITLLPFLETLADAEDVRPLIAKRFGNKE
The following text describes a protein:
Function:
RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (By similarity). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (By similarity). In addition, also controls telomerase holoenzyme complex localization to Cajal body (By similarity). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (By similarity). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (By similarity). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (By similarity). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (By similarity).
Subcellular Localization:
Nucleus, Cajal body. Chromosome, telomere. Chromosome. Note=Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies. In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM.
Sequence:
MKTSEERLLAPDSLPPDLAPAPVPQGSPAEKNTDFEPVPPPCGGDDQPQLATDPVASLVVSQELQQGDSVPLEVEFNTSSELSPGIEEQDVSEHASLPGEETNLPELESGEATEGVSEERAEVDEGDTFWTYSFSQVPRYLSGSWSEFSTRSENFLKGCKWAPDGSCILTNSADNVLRIYNLPPELYSEQEQVDYAEMVPVLRMVEGDTIYDYCWYSLMSSTQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTSRPGRDCEVRATFAKKQGQSGIISCIAFSPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARKDAELLCWDLRQPGHLLWSLSREVTTNQRIYFDLDPSGQFLVSGNTSGVVSVWDISGALSDDSKLEPVVTFLPQKDCTNGVSLHPTLPLLATASGQRVFPEPTNSGDEGELELELPLLSLCHAHPECQLQLWWCGGGPDPSSPVDDQDEKGQRRTEAVGMS
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MATPIAIQFKPSILSFLSPNSSSVTTKAHFLQPNDKFLVSSPLKQIVPSLSSRHFSFLQQQQLSSTRFVASAAPGVADTVEKDKLPADIHVTETQEPNSRVRLTVEVPTVVCEDCYGRVIREFMKHSKVPGFRPGKNVPEDILVGYVGKQNVQKAAVESILKRTLPHAMSSITGKALEDSIRIATKFADMEKTYVSTNSLRYDVIVDVAPEIKWKPDNAYKNLKVVVELDSDMDAQTASEKEFKRRHKSLGALKIVTDRGLQVGDVAVIDISATTIEQDGSDAKSIPAAESKGFNFDTEDGDNVLPGFLDSIIGIKRGETKSFPLVFPDSWKQEDLRGVHAQFTVECKELFYRDLPEVNDSIADKLIPGCSSIEEVKQALLQRCLEVEQAAKDQATDNAILDQLYKMVEVDIPQSLFEEQGRQLYGAQLLQLQANMKLSEQQLASLSSPRAVNEFLEAQKENITSIIKQNLAVGDIFIRENLQFSTEELVKEVQNSIEEFQKSQQEYDEDRVKQQVQEVLEGAKVLEWLRENADIQYITR
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MSHGKVKELVDNQLESELSSAGKKLVVVDYTAVWCPPCKAIAPIFAQLSNEYPDVVFLKVDVDQCRSTAQSQGIRAMPTFQFFIEKQKVHEFSGADKSQLKNSIDRFKPQISFASQGQALGGGGGGGSGGGFQTYLDSLQKKQEEQQRQYQQQVGTTTPSSNPLNSLMGGSDAPKTKPAPKNTVPDPVMLRDLIDMGFPEFRAKKALVLTNNSSSQTAMDWIFENMDSETIDDPIEGIDLSTPTPAAPAATTPSQPTTEQSSTSSTTTTTTTEQPTTIHSALCDVCQEQIIGYRYKCDVCPNYDLCQKCKDTTKHNPEHQFTQHEKDIENYQMTPEERAEQKRKLEARILEIRAKKAEDEAKREIEREISRRQGGKMSQQALTKWQEDQLKREAEKDRKEKEADRIAKAKIKAKVEADRLERIAKKNAAAGNGAEAPKPTPAPVAPVVHTPAKTYTDSLIQIRLSDGSTIKGTFPITAKLIDVHTFISKNTSQHGKFTLSTTYPRKIYTQAELSTTSVEEAGLVPNGTLVCTKQ
The following text describes a protein:
Function:
ATP-dependent kinase whose specificity is not yet known.
Miscellaneous:
MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCDKSKTVLDYTIEFLDKYIPEWFETGNKCPLFIFFSGPQGSGKSFTSIQIYNHLMEKYGGEKSIGYASIDDFYLTHEDQLKLNEQFKNNKLLQGRGLPGTHDMKLLQEVLNTIFNNNEHPDQDTVVLPKYDKSQFKGEGDRCPTGQKIKLPVDIFILEGWFLGFNPILQGIENNDLLTGDMVDVNAKLFFYSDLLWRNPEIKSLGIVFTTDNINNVYGWRLQQEHELISKVGKGMTDEQVHAFVDRYMPSYKLYLNDFVRSESLGSIATLTLGIDSNRNVYSTKTRCIE
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MISPSTKLYGLIGYPLGHSISFYIHNAAFRALSIDALYLNIPIEPEFFSKAILGIKYLPIYGLNVTIPHKESIIEFLDEISEISNILGAVNTVYRENHKWKGDNTDFGGFLKTLEDLNLSSDFSCLILGAGGAARAVIYAVLEYGFKEVYLTNRTYERAEKIAVEVKKNKNFEIKVIPWEDREKISEKVILINTTSIGLDGKETPWNGDFKKLVFVYDIIYNPKETPLLKLAKENNVPYKNGLDMLIYQACLSWEKWFGFVGPFEVMKREAEKLL
The following text describes a protein:
Function:
Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDSLSPEEKLSLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLRFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRIHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYLDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPAVKGPAKNSEPEEVIPSRLDIRVGKVISVDKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASVEGVNRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISDEYIAQWKQTNFMTKLGSVSCKSLKGGNIS
The following text describes a protein:
Function:
Involved in the detoxification of the Fusarium mycotoxin deoxynivalenol by the transfer of glucose from UDP-D-glucose to the hydroxyl group at C-3, forming deoxynivalenol-3-O-beta-D-glucoside.
Sequence:
MADSDGSVHVLLLSYPAQGHVNPLLQFGKRLAAHRRVRCTLAVTRSLLNSCCRAPPSPGGGGGVHVATYSDGCDARGYDELGDEGAYLSRLESAGSATLDELLRGESGEGRPVRAVVYDAFLPWAAPVARRHGASCAAFFTQACAVNVAYAHAWAGRVELPLPTSAPAPPLPGVPPELEPADFPTFLTAPAAGRSAYLDLLLRQCQGLEVADHVLVNSFHELQPKEAEYMAATWGAKTVGPTVPSAYLDGRLPGDASTTRRTEVEGQKRNFACNNRIGRDGRAARTLEALGFLIDRRRRLLEVNSAVAAAASGKDDIDAATVAGNDKFAAAVACFNVAAATVAGKDDIDAAAAGKEDIDAAATGNDEFATAAAYFNTAAARKDEFVAAAAACFNACRNPPLAAT
The following text describes a protein:
Function:
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Sequence:
MAVTVAVGTSNPIKYRAVLRAFSRYYDVRVVMVSVDSGVGPQPSGVADVVGGALARAVRAVEKADSYFGVGVEAGPIEFPASGGYVETQVAAIVDRDCRATIGMSPSFEVDRRVLALMLDGVEMEKAVGVERHGGLGESVGFVGVATSGAVTRQDLTEHAVIMALIPRLMGYGSIATVEEIAAQAGASVECRSTRAI
The following text describes a protein:
Function:
Involved in assimilation of trans-aconitic acid. Preference for cis-aconitic acid is 14-fold higher than for trans-aconitic acid. Not active on intermediates of tricarboxylic acid (TCA) cycle including citric acid, succinic acid, fumaric acid, and 2-oxoglutaric acid or on other dicarboxilic acids including itaconic acid, formic acid, citraconic acid or maleic acid.
Sequence:
MFPRLPTLALGALLLASTPLLAAQPVTTLTVLSSGGIMGTIREVAPAYEKATGVKLDIAAAPSMGDTPQAIPNRLARNEPADVVLMVGSALDKLVASGQVAKDSRVDLGQSFIAMAVRQGAPKPDISNMDAFKQTLEKAQSVAYSDSASGVYLSRILFPRMQLDKSFMAKARMIPAEPVGAVVARGEAQLGFQQLSELKAVPGIDIVGLIPDQAQKMTLYSGAMVSKSQHPEAARALLQYLASKDAAKAIEDSGLKPVPAQP
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Sequence:
MTANDPLSDALSGIDNAESVGHLTHTVAPASNMVGSVLEVFYDRGYIDGFEFVDNGKAGRFEVELKGAINECGPVNPRYSVGADGFEQWEKRYLPARDYGSLVVTTSHGIMSHYEAREAGIGGQVIAYVY
The following text describes a protein:
Function:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
Subcellular Localization:
Cytoplasmic granule. Golgi apparatus. Secreted.
Sequence:
MKFTIVFAGLLGIFLTPTLADYDISVNDNNNSGGSGQQSVSVNNEHGVANVDNNNGWDSWNSLWDYGSGFAVIRPFKKKSCIVHKMNKEVMPSIQALDMLAKKNKLQGRGPEGPPPKSLIYSVKPDKVNNLDQFGKFIVTMCKGIPTYMAEEIQGANLILYPEKCFNVDILWILNISLCEEAMEN
The following text describes a protein:
Function:
Male-specific peptide with moderate activity against Gram-positive bacteria.
Subcellular Localization:
Secreted.
Sequence:
MKYFVVLVVLALILAITVDPSDAVFIDILDKMENAIHKAAQAGIGLAKPIENMILPK
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSLILSQINKDNVKVGKGCCIALGVQIISEIGEIIIGDYTIIEEGCIIRNNQFKKMVIGSYNVFEIGCKVENANIGDCNVFEMRCIIESGCTIENNCRFGINSRIPPKQNFPNFSRVYYPFNCLKVPPYDSSQHKEEISELCAALFQMGSKK
The following text describes a protein:
Function:
Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MASKTVKTSDEILCEGELEKRSDSLFQVWKKKRCVLTADRLRLFSGNSDRPKELYFHSILKVDCVEHTSKYVYFTIVTNFYKEIDFRCTVESCWNAAITMALIDYQNRRALEEFRRFRYQHSASETQSSPGGRRALGP
The following text describes a protein:
Function:
Probably involved in the biogenesis of the COX complex.
Subcellular Localization:
Membrane. Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MLLFRSGIKFRNVFQRSVTTLKKQRTGSSPIGKFLVVVPFLCLGLGTWQVKRLKWKRGLIRSMNESLDNDAVPLPSHITQQALKGLEWKRVWIEGQLQHHQEMLVGPRTVDGFTGYHVVTPLIMGDGRRILVKRGWIPRELKDQKSRDPASMPQGKVRVEGLLRTHSDRPWYMQKDRLSKDEFFFVDVNEMSTLTGSEPLLLVQLAEPNETTAAAQNAAKDGFPIAEPREVKIFNSHMEYIITWYSLAAVSAVMLYYFRKNGRKTFQQDALNERIEAMKRL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MADAGNEDQNRRMDLNLYLGLPRSPRRRELDLGSDLALGSLPVSGEAEVRGSTEMSGYAGLSDSHAPYSPSHASHSPSPQAVEPLDRNENSSFTYPDYSPPSPSFPSASQAMQPGVESLVGVSRSHPEYSPYSPSYDPVIPTAEARLEPAGQGVNDPIDHAPYSPSYAPVSASEHEDTETVVHEGGNHVEYVPYSPSYVPASLSPPGPSSEPLIQEENPHVPYIPVSPSDQTHHGQSSGLVPEVTGFGAEQVTAQGRDTPVGDGSLQRELLQYPEFRIRRLIELSRRWGVRRFRSTVPYNLSPNLDAISSESHAFRTMATTEESNEANGENEKTSLEGSAAQDIKDGTKEQSSGTTSFDCNICLDVAKEPVVTSCGHLFCWPCLYQWLYLHCDHKECPVCKGEVIESKIIPIYGRGNSEMGVEQKEQEVGNSNLKIPPRPRGHRFESLRQQIRRPLSRRLEEIGSWRLIFGEETHSGNREGQEEPSTQRIVDGVRRSRRIARFMETQRFHMGDGLESRFNLRGNETSRNAIEMALNYTQSGNLPPEGLHGSESRSTPPAIARHGISFWPGHPFYSVPISERLAALAADVAGRIQDSSNHSGASASVDPQDSNANVQSTREATVAADQVSASSTMAVIQGDAGVPVDAPSEPNSGSSSRSFRRRRRNSVSGSLDVDGGVHHVRKRRRLN
The following text describes a protein:
Function:
Probable transcription factor. Plays a role in regulating heme-dependent expression of heme transporter hrg-1. Modulates lifespan in a daf-16-dependent manner.
Subcellular Localization:
Nucleus.
Sequence:
MDNNYLDASHRKRLVCSNCNGTNTTLWRRKAEGDPVCNACGLYFKLHHVTRPIPMKKNKKHAVLPAPGISKL
The following text describes a protein:
Function:
Needed for flagellar regrowth and assembly.
Sequence:
MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEAKAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAKKVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECRLGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE
The following text describes a protein:
Function:
Probable zinc protease.
Sequence:
MLTRDEARSQTPSAIRRVSSLEQPAIKAPSRTDRVDHLSHFDITFTIRDKKQRIKLELEPNYDIIADDAYVQYLGADGKVHTEEPIARDKHKVFKGRTLIGRGKGQGMWEPVGWTRIYVKEDGPRPLFEGVFNIRGDNHHVQLQSTYLQRKRPQDVDIPRQDGEYMVFYRDSDMLRAETPARVDLKRSLSTDDSHELESRWDMVGSTCQADKLDFNSDPNHPVLHSFTETKSSWASMPMADLFGLGFSKRDDINTVTGNGGGVNLQATIGDTSGCPSTKKVALVGVATDCSFWEKFDGRDDVQQSVVSMVNSASDVFESSFNISLGLRNLTITDRECTETSSAVQWNMPCSQGNITQRLDLFSDWRGEQSDNNAYWTLMTDCNTGPEVGLAWLGQLCNNKASGSVSGTNVVVSTGAAGWQIFAHESGHTFGAVHDCTSQSCSQNQQSSSTQSGCCPLSTSTCDAGGDYIMNPSTSSDVTKFSQCTIGNVCSALGRNTVNSECLSDNKGIVTITGAQCGNGIVEEGEDCDCGGSEGCGDNKCCDASTCKFTEGSVCDDANDGCCTSCQFSSANTVCRASTGVCDIEEKCTGNSSTCPTDTYKADGDSCGNGLQCASGQCTSRDEQCRTMLSSEIGSNDTTACDDSKFPSCQIYCSVSGGSSFGVIQCMTNAQNYIDGTPCENGGRCRSGICEGGKSWLEAHKNIIIPVVAGVGGLILLAILVCLFRRCRRTRYTMKPIPPVATAYSPWPRRMPPQPQQTPMRRLSRSPGSGYGQVPQAPYPSPYGHYPGPGPQRGPGPIPSPYPGYSGPGMYEDPPPGYTPTVRYA
The following text describes a protein:
Function:
May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking. Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Note=Appears on coated vesicles in successive transient bursts, immediately after the vesicle release from the plasma membrane. Recruitment to clathrin-coated vesicles depends on temporal variations in phosphoinositide composition of clathrin-coated vesicles.
Domain:
The J domain mediates interaction with HSPA8/HSC70 and is required for basket dissociation.
Sequence:
MKDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVTSYTKGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPLTIKSITVSPIPFFNKQRNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVVVSMYHLRSTIGSRLQAKVTNTQIFQLQFHTGFIPLDTTVLKFTKPELDACDVPEKYPQLFQVTLDVELQPHDKVIDLTPPWEHYCTKDVNPSILFSSHQEHQDTLALGGQAPIDIPPDNPRHYGQSGFFASLCWQDQKSEKSFCEEDHAALVNQESEQSDDELLTLSSPHGNANGDKPHGVKKPSKKQQEPAAPPPPEDVDLLGLEGSAMSNSFSPPAAPPTNSELLSDLFGGGGAAGPTQAGQSGVEDVFHPSGPASTQSTPRRSATSTSASPTLRVGEGATFDPFGAPSKPSGQDLLGSFLNTSSASSDPFLQPTRSPSPTVHASSTPAVNIQPDVSGGWDWHAKPGGFGMGSKSAATSPTGSSHGTPTHQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQGGAYNWQQPQPKPQPSMPHSSPQNRPNYNVSFSAMPGGQNERGKGSSNLEGKQKAADFEDLLSGQGFNAHKDKKGPRTIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTMHTVLWAGETKWKPVGMADLVTPEQVKKVYRKAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGQKPLY
The following text describes a protein:
Function:
Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the 21S rRNA gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Specifically recognizes and cleaves the sequence 5'-TAGGGATAACAGGGTAAT-3'.
Subcellular Localization:
Mitochondrion.
Sequence:
MKNIKKNQVMNLGPNSKLLKEYKSQLIELNIEQFEAGIGLILGDAYIRSRDEGKTYCMQFEWKNKAYMDHVCLLYDQWVLSPPHKKERVNHLGNLVITWGAQTFKHQAFNKLANLFIVNNKKTIPNNLVENYLTPMSLAYWFMDDGGKWDYNKNSTNKSIVLNTQSFTFEEVEYLVKGLRNKFQLNCYVKINKNKPIIYIDSMSYLIFYNLIKPYLIPQMMYKLPNTISSETFLK
The following text describes a protein:
Function:
Probably involved in biosynthesis of the precursor for C25 (sesterterpanyl chain) moiety of C25-C25 diether (2,3-di-O-sesterterpanyl-sn-glycero) membrane lipid. Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield all-trans geranylfarnesyl diphosphate (GFPP). Geranylgeranyl diphosphate (GGPP) is the preferred substrate, however methylallyl diphosphate (DMAPP), farnesyl diphosphate (FPP) and geranyl diphosphate (GPP) can also be used as allylic substrate.
Sequence:
MLIDHYIMDFMSITPDRLSGASLHLIKAGGKRLRPLITLLTARMLGGLEAEARAIPLAASIETAHTFSLIHDDIMDRDEVRRGVPTTHVVYGDDWAILAGDTLHAAAFKMIADSREWGMSHEQAYRAFKVLSEAAIQISRGQAYDMLFEETWDVDVADYLNMVRLKTGALIEAAARIGAVAAGAGSEIEKMMGEVGMNAGIAFQIRDDILGVIGDPKVTGKPVYNDLRRGKKTLLVIYAVKKAGRREIVDLIGPKASEDDLKRAASIIVDSGALDYAESRARFYVERARDILSRVPAVDAESKELLNLLLDYIVERVK
The following text describes a protein:
Function:
Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection.
Subcellular Localization:
Nucleus. Note=Localized in the nuclei of daughter cells.
Sequence:
MHWKFSNFRKYHLSFHLNLFDLSLFFISFYCFPILYICFFNQVHSFRSTQPSLIMNKFDLFDDYSTKGSTIPLPNENFDQLFLSSEANDMEFLFNETLMGLQDLDVPSGYGIPQNTINNDFQHTPNKSKSHSRQYSGTAIFGFADHNKDLSINGVNNDLCKQSNKAINTQSVSPGELLKRSRGSQTPTPTSALPDTAQDILDFNFEEKPILLLEEDELEEEKHKQQQRMMTQSSPLKRVTTPSQSPFVQQPQTMKQRKPHKKTNEYIVANENPNSYKFPPSPSPTAKRQQYPPSSPIPYNPKSDSVGGNSYSAKYLQSLNKTQQIEYVDDIEPLLQEDNNNMKYIPIPVQEPMSYQKQKPVTPPLQSQNDSQQLEPLKTPQPQPKQQQQQQQPNNEQDKEFTANFNFNTFLPPPTPPNLINGSPDWNSSPEPHSPSPGRLQPPQQISPIHQNLGAMGNNINFYTPMYYELPVQAEQPQPQPQPHQQQHQQQQHQPELQNTYQQIKHIQQQQQMLQHQFHNQNNQLRQQHPNQFQNQNQNQNQNQTKTPYSQQSQFSPTHSNFNLSPAKQLNSNVGSMHLSPLKKQLPNTPTKQPPVTIEWSPVISPNSKQPLHKQIKESSPRRRIKKTSLLPPGELDNYWTGPDEDKIYTCTYKNCGKKFTRRYNVRSHIQTHLSDRPFGCQFCPKRFVRQHDLNRHVKGHIEARYSKCPCGKEFARLDALRKHQDRNICVGGNKNVISKPTKKKGTNNTQQQLLKTDTVVERIEKQLLQEDKSVTEEFLMLQ
The following text describes a protein:
Function:
Required for the processing of the 27S pre-rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVRKMNSLAKRLAANSKSRQPEPESDSDGSDFDFDNAIEEKTWEKPLDAMEVEEAESDGDDDEKELQAAFAAGLLKDGLNIQVAKKRPIINKSAEMKEKLAEITKDLPWVETLEVVTPHAEMDMKVENDDFQRELNFYKQAEKAVQTAYPRLLNLGIKVLRPSDYYAEMAKSDSHMQKVRKRLLGIQEMKERQEAFRRIREEKKFAVKVQKEAIANKNNEKKKLAEAVKKHKKGMKQQLEDMLNNVKRHGLDQDDDGPSSAYGDRRGGRGGSGRGGSMRNAGELKRKLKSDKFGYGGKKKGMKRNNKESFNDLFGAPRGGFGRRGRGGGRGGRGGRR