lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNLRLEDGRSEERSGGKASNSTNHIIIINDEMPSFSATDVEESKSEMLPVKTEKGQPGSEDHLKQKKSSVLNFSAGRTQVLALRDKKLENETLCPKEHHTSANTQRCSLTVPEIFPPRSEKDHPNSEGYLDTMENTGVTFIDENGLEIIPPGVKINDLKILQIKIEEDDPEDSWSSGSEDSDSPETVTTPKEPFVCTYCGKEFNKKFNFQIHQLVHTGEKPFTCSECGKSFSQKRILQTHLKVHTGEKPFTCTECGKCFAQKIHLHTHQKVHTGEKPHTCPDCGKCFSVKSNLRKHQIVHTGTKPFTCTECGKSFSEKGSLQRHLKVHTGEKPFKCTECGKGFTRKIHLTKHHKLHIGVSKGELPVPEEEVCWSWLEDGCAIISDIGQLPITNMDPHSPLRQFRENPLDCRRHGTAIKTENGAEPEILQVKIEKSDSEDEGDDGESLKERKQGNDKLDSAPLIRIKTEMHSSSLSDCAPEIINIKIEKDESDCEDNVSTEGSAAHMHPDGEADSKCESRTRAEGGAKSSHFICCKCGESFAPSSDHTHICAPTGERLFSCAECGKSFSTKGSLHRHKTVHTGEKPFACVKCGERFSRKSYLHNHQRAHTGEKPFNCTECGKNFSRKGSLQRHQIVHTGEKRFTCTECGKDFSEKTTLHIHLRVHTGEKPFTCSDCGKTFSQKSNLYTHYKVHTGVKQYSCTTCGKSFAEKTTLNTHLRVHTGEKPFTCTDCGRSFSQRGSLNTHRNTHLGAKALSIPEHGEESSS
The following text describes a protein:
Function:
Required for normal Golgi morphology and function.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGTLHGEKTMFASPNTFYIDESKLCFNKTHFNREDFNVERFMNLARQKSDLKTIQQDLRLYLKSVQNSMIELINDDYADFVHLSSNLVSLQDSLNKIEQDINRIWDEFKESTRESVGMAERIEQKCDELCSNREKQIEIRDRIYFLVAIEKLSEMLLHPPRKCSALWLQKAASFASELKGSTFPHSEEENAAEKIILSQLEAVLCAEGVRSAAGDCQNLPLIYSILSLTESTHSLTALLVSDLLYAEFVNEKHDESNQLKLLKQVFESVKKMRETWAEKMGTEHFRGNIRRFLDETLLTFILTFIDKCMGAVAVPSDTRLFHECFLLTQEFIDNWPSSHTCRAMLKSIRDKFNLLVYFKLETHRFGKQCDQLMSPEMFAEPETSENRENTPQLHCGVSRAIITAIEHVWSDDVYLPPIVDKLWDFTLKLLLKHFSWSQTMKNYFMEEKRDWTSMVTLRSDTGNLHQLVFDFALESIWGKFHDITVDTAPFGQCLTKHGRSIDSLCVQIDDSIIEMFSEVLHQEIAQVSDVPKQYRWTKKSPPTTHSKYVVTAIEMVENLKEKLCCEEHPHTDEIVRKVNLSAFNYFVGKGNEVLDSVEATGSSLSRFKRKTTTDSGSTVTDDDKIKQQIYHDAKYFLSYAENLVFSQADLTGLQEVVNRFDKDARSAIVQEKNQNEEAGNA
The following text describes a protein:
Function:
May play role in regulating embryonic neurogenesis.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MENEEWKVSVWICQEEKLVSGLTRRTTCADVVRVLLADHNEKQAEEGSMLMGEEGSMLLGPPQCYCIVEKWRGFERILPNKTKILRLWTAWGEEQDNVKFVLVRSEASLPNIGPRSAEAKVVLSKESPCHQRTLSKTSTGPTQDKQRRVVRKAFRKLAKINRKRHETLPKESSSVEKMETLVHLVLSQDHTIRQQVQRIMELDREIERFEARTHFDRMKMHGVNYVQETYLVGTVSEKGSASDSNPPSDQSSQEELFADYAQKCDEVLLLQEQISRQEEAMEQMTVQIQEELNKRWMERRQEELSSKEQESSLSDSGADQGGDESQLLLEQEQVKTELSASLYIGLRLNTDLEAIKADLDYTQKMWDDKEQELQSLLHSLNDLETSGCQDLAEISCEDTSLGVTTTGSPTDSWVEKDLGRPTNCEANDEDSDTGLSSMHSQDSDSGPVCESLV
The following text describes a protein:
Function:
Channel-forming component of a multidrug resistance efflux pump.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MRKPAFGVSALLIALTLGACSMAPTYERPAAPVADSWSGAAAQRQGAAIDTLDWKSFIVDAELRRLVDMALDNNRSLRQTLLDIEAARAQYRIQRADRVPGLNAAATGNRQRQPADLSAGNRSEVASSYQVGLALPEYELDLFGRVKSLTDAALQQYLASEEAARAARIALVAEVSQAYLSYDGALRRLALTRQTLVSREYSFALIDQRRAAGAATALDYQEALGLVEQARAEQERNLRQKQQAFNALVLLLGSDDAAQAIPRSPGQRPKLLQDIAPGTPSELIERRPDILAAEHRLRARNADIGAARAAFFPRISLTGSFGTSSAEMSGLFDGGSRSWSFLPTLTLPIFDGGRNRANLSLAEARKDSAVAAYEGTIQTAFREVADALAASDTLRREEKALRALANSSNEALKLAKARYESGVDNHLRYLDAQRSSFLNEIAFIDGSTQRQIALVDLFRALGGGWDEGRSLVVHRGGRS
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity). May have a structural role in maintaining the cell envelope integrity.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MQNAKLMLTCLAFAGLAALAGCSFPGVYKIDIQQGNVVTQDMIDQLRPGMTRRQVRFIMGNPLIVDTFHANRWDYLYSIQPGGGRRQQERVSLFFNDSDQLAGLNGDFMPGVSRDEAILGKEGSTTVTQPADQQKPEAQKEEPPKPGSTLEQLQREVDEAQPVPVPTPEPLDPSPQ
The following text describes a protein:
Function:
Required for normal microtubule organization.
Sequence:
MSWRYSILTVDGSFKIFIPWEIFLTWNFLSAAWLNSTESNTYIHYSTCWGTSDYTLNISVIEATTEKLVDTRLLTTLENATAWINSNSIDEDEDDMPHATNVADRLDGLSLSKRVYSICHYEF
The following text describes a protein:
Function:
Regulatory protein involved in autolytic activity, multidrug resistance and virulence. Controls autolysis by inactivating LytM, LytN (autolysins) and SarV (autolysis activator) and activating ArlRS, LrgAB and LytSR (autolysis inhibitors). Acts as a dual regulator for resistance to multiple drugs by inactivating NorB and tet38 and activating NorA. Positively controls the expression of virulence accessory gene regulator (agr) to promote alpha-hemolysin (hla) transcription and down-regulates staphylococcal accessory regulator (sarS), leading to repression of surface protein A (spa). Binds directly to hla promoter to augment its activation. Binds to sarS promoter to down-regulate spa expression.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVDLIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK
The following text describes a protein:
Function:
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Involved in the fusion of the mitochondrial inner membranes by mediating cleavage of OPA1 at S1 position, generating the soluble OPA1 (S-OPA1), which cooperates with the membrane form (L-OPA1) to coordinate the fusion of mitochondrial inner membranes. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1, leading to excess production of soluble OPA1 (S-OPA1) and negative regulation of mitochondrial fusion. Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization (flickering) by catalyzing cleavage of OPA1, leading to excess production of S-OPA1, preventing mitochondrial hyperfusion (By similarity). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity). Binds cardiolipin, possibly regulating its protein turnover (By similarity). Required for the stability of the respiratory supercomplexes (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Domain:
The stress-sensor region regulates proteolysis and activation.
Sequence:
MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS
The following text describes a protein:
Function:
Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.
Sequence:
MGKLLLWVGLVLVLKHHNGAAHKLVCYFANWAFSRPGPASILPRDLDPFLCTHLVFAFASMNDSQIVAKDARDESIFYPEFNQLKERNEKLKTLLSIGGWNFGTSRFTTMLSTFTNREKFIRSAIGLLRTHGFDGLDLFFLYPGLRGSPRRDRWNFLFLLEELLLAFRREAQLTMRPRLLLSAAVSADPHVIQKAYDVRLLGRLLDFINVLSYDLHGSWEKVTGHNSPLFSLSDDPKSSAYTMNYWRKLGAPPEKLLMGFPTYGRTFRLLKASKNELGAEAVGPASPGKYTKQAGFLAYYEVCSFVQRAKKRWIDHQYVPYAYRGKEWVGYDDDISFSYKAFFIKKEHFGGAMVWTLDLDDVRGTFCGTGPFPLVYMLNDLLLKAEVSSTLSPGFGLSTTVNSSRTCPESLAVTKDLTTDLGILPLGGEAVATETHGRSDNMTVTPGGGLVAPTRPTLSFGKLTVAPEGKTESPGEKAMTPVGHPSVTPGDMSVPPVPIQTGDRITPPRRQAVAPEKMTLPSGKRSD
The following text describes a protein:
Function:
Transport of uracil in the cell.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVLFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTIIISITTLAVTVLGSVLFRGFLAIIPILIGVLVGYALSFAMGIVDTTPIINAHWFALPTLYTPRFEWFAILTILPAALVVIAEHVGHLVVTANIVKKDLLRDPGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFAILLSCVGKLAAAIQMIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGAAELKGMALATIVGIGLSLIFKLISVLRPEEVVLDAEDADITDK
The following text describes a protein:
Function:
Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.
Subcellular Localization:
Apical cell membrane.
Sequence:
MPPSGVQVGPVYDGIGDPTTPGWPSTGECERLSDKEVENKGNVPLIPSLPISWADGDVIIRTISGKVANVYWKGGEDSPIYRVGPGPAIANLSYEGQQVIITIQNVIAVIEGEEEPDRFVILGNHRDAWTFGAVDLNSGRATLLVIAQRLEKLRKIGWKPRRTIVLCNWDAEKHAYKHICVQAKFTSQIGSVEWVEENREMLAARVAAYLNVDCAVQGGPFRASAIPQLDDIIIEAAQKVQDPDNSSQTIYQSWLASDNDTTLGRLGGAGSDYAAFVQHIGTPALDMSFGNGYPVYHSMYDDFVWMKKFGDPMFHRHAAVASIWDLVALRLADDEVLPFNYLSYAIELQVSLNHNGISLVPLYASIEKLRKAAKKIRDDIKVQYERSLAKRRRASVREVRELNDRLIMTERTFIDRDGLSSRTWYKHLIYAPTRHNAYVSNSFPGISDAIERAKSLNTPDSWRSVQHEVWRVARASHKPH
The following text describes a protein:
Function:
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Subcellular Localization:
Chromosome.
Sequence:
MTPKANLHVDCYFVLLQIRIQVSLVDGPGAGQMEEDRTNHDEGNRLSPTLLYSASACQNKNGALQNGNLPTDKDHLQVNGDICLPTKNNYSVAYMKGSQEHGASDFIHENTAYSNHVQNGGIKRTFSEPLFSELHQLKKVRTDEINGENKGDQNNIQASVSEFCNEDRSGRLFQPVNSDSSALQVPNEQKQDLNYINRDIVSCHNDKTVPMCNGATASVSSMETVNNELLEKMPSQYYPEHVSTVVHNNTSLVDAINTLNDASNGLSTLATHSSHTSGQITPQQTLNPVLPQVSDVIVDEAHNSDHGSEPVVIPGSYSLNRQEQKPLVQESLHYNSHNLVGGKGDARESMGQMSTQCLDDSGNSSFHIQNSSSNEIPSGLEAIKKDPLPSLQINHIMDNKQKEEPSISETHDRHHLNLTKTSESCHSHDPRVSPHHNEQQLQNERKGMFPLTRLPALHSSVTEILAKHKFKSILEMQNEHLGQNKVMQNCNGTSKDDSFIKATKDFKSNPFLKSGWLELRPNQRLKEGSSENSCEDLLNLLLQSQSNNKKKLRQYPGKHNITNRKCNSQDSEATPLQQNIPEQQPNFLKHFSQDSQFQPYIQKSNADLMSFQSILEQASEGLQLSDAQQFLQAQPNEYIDELLRQHFEQSLRNCNQNRDSPLNHLKLEDSAQAANQYLKHHQYPLASQQFETELKQSLSNINSPFSQNQENNTVNPNHSYADKQVYLSQKTENSCGFAENKPDPLQYMQYYQPNSTQQQEINNYEHDLSSRIAKQTHCLPESFSPSPHLQDKMRYYSKFSNQIDCIPKHAALRNHLLQRKEQASRPVKAEKSSHSNACMHTPMESKIKKNTDKKIKQETHHSSTEAGQQKSIIETMEQKMRHYPGKSQFHRQVSSIKSPKHVKVESAGPVTVLTTHTTLDQQTIPPYEKTPTKRAAGSALHNFIESPSNLLSTPVKNLFDTPIKTQYDFPSCSCVDQIIEKDEGPYYTHLGAGPNVAAIREMMEERFGQKGNAIRIERVIYTGKEGKSAQGCPIAKWVIRRSGTDEKMLCLVRERAGHSCETAVIVILILVWEGITNSLADRLYSELTETLNKYGTLTNRRCARNEERTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKVPRKFRLTSDDPKAEEKLEANLQHLSTMMAPIYKKLAPDAYNNQIEHEHRAPDCRLGTEEGRPFSGVTACLDFCAHSHRDLHNMPNGSTLVCTLTREDNREVGKNPQDEQLHILPLYKVSNVDEFGSSENQEEKKRNGAIQVLTSFRRQVRMLAEPVKTCRQKKLEKQEAKKAAAEKLNSALENGHSKNEKEKPSRHKNVHVEASVQEKQQAEFSRMPAMHQNPILNMNQGNSLNHYPASVPTNPYTQIPNLPDPYQNSFPLYHGSRDMNIFQAAASASVSCANSPMNSFQGSFNQGNSCPPYPSNGNASLDNCSPYLDSSQQQSMDYYKFKNQDPVAKLGVPPNQSLYQQGFSNSQAYGHKMFSYGNQRVQADDFSGCNAYPSPQADSHVMGPATNSRPIISNGEYPLPHSFQSHESNMSSSILGDRAGSLPFLGKQSEMHSQASNGTSEMLPGLNHDRTNFGGLGRTNGANVQGKLPYTLPPVPEEPAEVWSDSEQSFLDPDIGGVAVCPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALWEAKMAGKAREKEEDCERYGPDYVAPKSYNRKAKREPMEPIHEPAEPTYLRFIKSLTQRTMSITTDSQVTTSPYALTRVTGPYNRYI
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Sequence:
MARDEHDSRYLTAELPGTGGLFKETPEDFLVEEISLYLPCGEGEHTYAVIEKRGITTLEAIRRLCRATGAPERDTGYAGMKDARGITRQTVSLPRVTPAEVMGLNIPGIRILSADRHRNKLRLGHLAGNRFRLRLRETVPDAADRARAILDVLARRGVPNRFGEQRYGIQGNSHLVGRAMLAGDWRGAVDLLMGDPAKVEGERWRAAIEAYRQGDLAGSLSLFPGHCRTERDVLQRLAKRPDDFERAVHGVHPRLKKLYLSACQSALFDRVLETRLQTIDHVMEGDLAWKHDNGACFLVTDAKAEAPRAERFEISPTGPLFGCRMTSPEGEPAALEKSILDAAGLTPAAFNLAGGLRMEGERRPLRVPLEGPELSCEEEDLVLRFSLPRGSYATAVLREVMKRPGNGA
The following text describes a protein:
Function:
Pseudouridine synthase that catalyzes pseudouridylation of mRNAs.
Sequence:
MFHSLSYINSHIGFCGTIKNYPSDFIVTEIDAQGRSVSQARAESRDDFREIPAEQRSSGQYNHKKPRSVPQKLCWEDGGNEEFTSLDKQSGPEEILKFAGEDEDSIALGVGDWECDKDDILDSSLNVAANESLNQFACDVKDTWNAKAERTDGSTELSLGAIIDKKQRACLHSAIRQKFPFLITVTRNQEIVVKPNGDYKELGRLVSEEEVNDFFRYLDAKRENSKFTFKPDSDKEHRKAVHHFVNQRYGKLVETKSFSVAESIAGDQSVVITVRFREKTFRGKKRPLSESQDKQDEYTAFTLRKENLETFEAIGYLSSELGVLPSDFSYAGIKDKKAVTYQAMVVKKVAPERLKEIRSAVEKKGISIYNIHSVHQPLRLGQLTGNHFDITVRDLKRQTSDSSAKPKESIVEAIENVKTRGFINYYGPQRFGQWQSVQTDQIGLALLNNEMVKAVKLFFTPEDLDDPVNRAKKHFFQTEDAKGTLALLPEYKLRERMLLRALNRYGVTEEGCTRGWLSIPHSMRIFYVHAYCSKIWNEAASFRLETYGSKVVEGDLVSSEEKGREHLPLSDRVHVISAEEEAANVYAIHQVVLPMVGHSIVYPKNKVGQWYRERLGRDGLQTCRFRVSALQLNIPGCYRQILKYPRNVSYHLPEDGDVDGRMEASLSDEPSASLHISFDLDASCYATVCLREIMKCDL
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Also regulates the sphingolipid metabolism. Required for growth during anaerobiosis and sterol uptake. Plays a role in pathogenesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MICIECGYSNIDCLYSKYKSDYIKLSVCPECNKIADKYIEYDSVILFLDILLLKRQAYKHLAYNLTEMEMEIGSSTNFHINDNTNFKFFHTYRKLMKLIFMILSFEVYLTWANEEKLLIHSQLINLIFNQSVVYQYLFFIIKSSLENLILNLSLQLILRLGYKWGQGPQKINGNIRDKELFGYKTSVLLVTTMVSGSIRLFPILMFIWPYDNISITKPLINLIAFINIVEALRVVTSLGYVELILSLAFSIVIRNIVSKSLLVLIVRLFLDFNFTEVYYNEMYQLYSQIQTYIRWI
The following text describes a protein:
Function:
Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Plays a non-essential role in ciliogenesis.
Miscellaneous:
MISCELLANEOUS: The N-terminal 3D structure (head domain) resembles that of NHEJ1/XLF, PAXX, SASS6 and XRCC4.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Localization at the centriolar satellite is dependent on intact microtubule network. Localizes at the centriole subdistal appendages and proximal ends. Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2.
Domain:
The coiled-coil domain is involved in microtubule-binding.
Sequence:
MEEPRCLQANCFFRGKEHSIQLSVSQAVLEVEVEERRSTKRWRGHFDAASVEDLTRKTGNFKQFGIFCSMLEAALMKSSEAVSLELLTYGDLEALRCCKVGVATRVPPSTSPLSSKRYLILVYCVEFDRIHYPLPLPYIGEADMAALRRLVQEQQDELAQLRDELRRAQQEVWRLEDERLRDKAWHQQEQRRMTKELTEVKAAEKMLRAHVKTLTAELAVCRKGRSTSATAPGCPQDRRRSNSRDSRSSSQGRLPPRSPSPAGSRPPRFNPTAFVRSREQRRQEAELRRQKLPRGTVSSGDNCRRRGRRSSSAESLQSRRSAQSSGSEADTCPQRRRGLGGPSTRSPLSASSCNSTSVASHPNRGCKQHGKENLGTEPSATLSEIDARLQALQAYISTLGTHM
The following text describes a protein:
Function:
Catalyzes the specific dephosphorylation of phosphoarginine residues in a large number of proteins. Counteracts the protein arginine kinase McsB in vivo. Can dephosphorylate CtsR-P; thus, can restore the DNA-binding ability of the CtsR repressor by reversing the McsB-mediated phosphorylation. Is the only active pArg phosphatase present in B.subtilis. Exhibits almost no activity against pSer, pThr, or pTyr peptides. Appears to play a role in B.subtilis stress resistance. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
Sequence:
MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPNGKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKVFTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR
The following text describes a protein:
Function:
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQPSSTTSLKPGVVLVAPSPPADENPKKNSFQKDEADKEDDQQQDEQGKSRQKSTYGKTMDGTVFKIPETHNMISSLFDPRLPKSSLDLITLSTLIAQTIPLMIFPRKKLKTFYMLSFLFWRLTYNVGLGWVLKKQSENKFLIKIIKNLNLFNSKFNPRLSNWIEKQLKSKMSTNNLNYDLNQYPIEFNVWLLFRQLVDIILLNDFFSYFCLSYCSLNLPNQQQSQQDPLPNQSNLSLFLIRCTAGVILVGFNIWVKLDAHRIVHDFAWYWGDAFFLSLQELVFDGVFEMAPHPMYSIGYAGFYGASLITGSQSVFFVSLFAHLCQFGFLVYFENPHIQRTYGPQARPLTAASPRHALRSRSHPRKKIQPLNFNSPNENPKAVSPDYRDTQHDTSSVHGSNTFHDPPQNPVDPAEVREELEHRLFRRKEMILIDNFDKFRSIDFVTVLVIGYNFLILFIKEEDPSHIKKIYNNKGLLISSLNAIAWRLWFSFGLGFRLKQQSQNKMMVKHFLTNYYYPIGKFRHSQQKNEDEINDDDQNDLIDELKFEVIEECFQNWKGIYNLSLIMTYVSFAIMSIKFHKLGDQWELSSEVIRITFGLCLVGIHVWTAISTYEVLGKFGWFYGDFFVDDYPMELTYAGIYRYLNNPERSMGGAGFVGMSLMSGNKFVFALALGSVLCHWWFLSFVETPHMKKVYGDRIRKEAGLTKVLKQNAQKLAARRKKLDLRIDRESCSSMGGGKSDEREGKGFERRFKEVQGTFEFIYDETVQALDEFLEKSAPRLSGVVRDTKVLLQSSGERLILTRIANDLSSYDTTQYRLAIQESRYHRPRDPASNRLRFHMGEPIRLQWNSPWNHSRADWVGCYRRGSNKSGLVTEVTSSGRWCGLFKEEWEGDMHIGKRRQEGDAELDDAGKELKLENEAAKPRKTGWVEFKGERLPWEEGVYEFRYHHDGKYNVMAVTEPFEIYVERIEQDVGNMKEIEDKLRNLVGYGLGMEANLIPMILRKETARILKDEFTKPSQNGIHAANGHQPATEGKVGENGLSDEGSQEEEDRFTVMSLDEAKRIQRLIGIGIGIELGIEIILEDCEINRLAKRIVFVKSLLKPFLNK
The following text describes a protein:
Function:
Involved in G-protein mediated signal transduction and in the regulation of polarized cell growth in pheromone-induced cells.
Miscellaneous:
MISCELLANEOUS: Present with 1240 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MQSSLPQFTFKWPKGPEAIILTGTFDDWKGTLPMVKDPSGAFEITLPVTFDSPSSKFYFKFIVDGQWLPSKDYKVNIDEGVENNFITEEDVIKQRENGSSTLVPESAGLAVSKNAPLIEPEAEKRAKKLRKFKIKRVIKTNKQTGERSIFSQEVVELPDSEDETQQVNKTGKNADGLSGTTTIIENNVGVNEEKAIKPYEENHPKVNLVKSEGYVTDGLGKTQSSESRLYELSAEDLEKEEEEEDEDKGGGKDTSTSADAEASEDQNKEPLSKSAKFEKPEEKVPVSSITSHAKETSVKPTGKVATETQTYETKQGAPTAAAKKIEAKKATRPSKPKGTKETPNKGVQKNPAKNGGFFKKLAQLLK
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing; Probable common Sm protein, is found in U1 and U2 snRNPs and may be part of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MPKIAPPELKRFMDKKLSITLNANRHVSGTLRGFDQFMNLVLDATVDEKLKVDIGMVVIRGNSIQTIEALEPIATGN
The following text describes a protein:
Function:
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MELSQLAVPSVYVLIFFLGYPSQWLLTQLEPRPLTKNELIFANVILVLIFITYTKSVFVDPGRIPKDWAEKQELGLSEEKKKKITRKWCRKCEAPKPPRAHHCKACKRCIPKMDHHCPWTSSCVSHTTFPHFLRFLVSTTVGLSFLQLLLFTRLSHLWNSRHLPASLGPSPFLLFHLFATTLANSLTLFAVGILALRNIWVLAINVTTIEGWEIERHRTLLRRARHFGGYLETPDGQAIRIKKQEFPYDIGILRNICQGMGSANPLMWFNPLAPSPSVQSALQFEVNGFEDEGTVWPPPDPDRSYKKVERGAEGEAFVFGGEGEGEDTIKAFRARQAQDVVRRRKPFVERLEERVDRDGYEDEYEYGEEASDGEEEEKESYGEGEGEEGWRNSEGERLQDFGVDEDVEFYDEQEDEIPLAELMARIQAASSGASYP
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MAVEVVQETLQQAASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGKSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENGFNVSLEKRQYATVA
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSDVEDVPETQLEIDVSDGAGLEDEDDDDMEQITAQKVLEIIETAWINEMCAPEILPSQTDMLELMVSQVAHMEEQMRDLDKNDFRAVVHSMELERVRYIMASYLRCRLQKIETFTQHILNQEESREPDDKRLSPEETKFAQEFASNVDEYFHKVATQYMPNQQRGEAEQRIVTPNLMSHVFLKANVAVPAVIVGVDDEEVDMAAGSQHIIPYQLVADLIQNNQAQLI
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MITPIHTQHSLILVYINIYSPPILSKLRTGFILWTNTQKTNKKRNMEDQFPKIETSFMHDKLLSSGIYGFLSSSTPPQLLGVPIFLEGMKSPLLPASSTPSYFVSPHDHELTSSIHPSPVASVPWNFLESFPQSQHPDHHPSKPPNLTLFLKEPKLLELSQSESNMSPYHKYIPNSFYQSDQNRNEWVEINKTLTNYPSKGFGNYWLSTTKTQPMKSKTRKVVQTTTPTKLYRGVRQRHWGKWVAEIRLPRNRTRVWLGTFETAEQAAMAYDTAAYILRGEFAHLNFPDLKHQLKSGSLRCMIASLLESKIQQISSSQVSNSPSPPPPKVGTPEQKNHHMKMESGEDVMMKKQKSHKEVMEGDGVQLSRMPSLDMDLIWDALSFPHSS