lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-dependent 3'-5' DNA helicase, unwinds 3'-overhangs, 3'- flaps, and splayed-arm DNA substrates but not 5'-overhangs, 5'-flap substrates, 3-way junctions or Holliday junctions. Not highly efficient in vitro. Requires ATP hydrolysis for helicase activity; the ATPase activity is DNA-dependent and requires a minimum of 4 single-stranded nucleotides (nt) with 6-10 nt providing all necessary interactions for full processive unwinding. The ATPase prefers ATP over CTP or GTP, is almost inactive with TTP. DNA helicase activity requires ATP or dATP and only acts when the 3'-overhang is >20 nt. Capable of unwinding a DNA:RNA hybrid if the 3'-overhang is DNA. Also catalyzes ATP-independent annealing of complementary DNA strands; annealing requires Mg(2+).
Domain:
Removal of the N-terminus decreases solubility and/or structural integrity of the protein.
Sequence:
MTDGPLIVQSDKTVLLEVDHELAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAEQVVDALVSYSRYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLVSLDRAVLEEVLRNKKIAPMLGARIDDDTVVVHPSERGRVKQLLLKIGWPAEDLAGYVDGEAHPISLHQEGWQLRDYQRLAADSFWAGGSGVVVLPCGAGKTLVGAAAMAKAGATTLILVTNIVAARQWKRELVARTSLTENEIGEFSGERKEIRPVTISTYQMITRRTKGEYRHLELFDSRDWGLIIYDEVHLLPAPVFRMTADLQSKRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECVEVRVTMTDSERMMYATAEPEERYRICSTVHTKIAVVKSILAKHPDEQTLVIGAYLDQLDELGAELGAPVIQGSTRTSEREALFDAFRRGEVATLVVSKVANFSIDLPEAAVAVQVSGTFGSRQEEAQRLGRILRPKADGGGAIFYSVVARDSLDAEYAAHRQRFLAEQGYGYIIRDADDLLGPAI
The following text describes a protein:
Function:
Member of the two-component regulatory system PmrA/PmrB that plays a role in the regulation of resistance towards polymyxin B and cationic antimicrobial peptides in response to limiting concentrations of Mg(2+). Also autoregulates its own pmrAB operon under Mg(2+)-limiting conditions. May function as a membrane-associated protein kinase that phosphorylates PmrA in response to environmental signals leading to activation of specific gene promoters (Probable).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSRAAVPSVRRRLLVNLLVGFVLCWLSVAALTYHLSLKQVNRLFDDDMVDFGEAALRLLDLATEDQAGEDGSITEIIERSREAIQGLPLLRRESALGYALWRDGQPLLSSLNLPPEITAQGPGFSTVEAQGTHWRVLQLNIDGFQIWISENLIYRQHTMNLLLFYSLFPLLLALPLLGGLVWFGVARGLAPLREVQAEVQQRSARHLQPIAVEAVPLEIRGLIDELNLLLERLRTALEAERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELSLHQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSIGLGKGLEGKGLEVQVFLPKTQPDATRPPARGPDSGRSHI
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TAF7 is responsible for the recruitment of BDF1 to TATA element containing promoters.
Miscellaneous:
MISCELLANEOUS: Present with 1100 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MAVIRIKKPRGPGEKDQPLEGEPKLKRIRIKTKVTDEDIKPKPKLKINLKKKKESADGKEKKNSLKLKLNLKKNEEPVKKIHKAPKLRLKPIRIPGEAYDSEASDIEDDPLIESGVILRILPDIQLEFVKNSLESGDYSGISIKWKNERHAVVTINDVMYGAILVDLPTVIEVNKSVDRKNLLKTFDVSQMLLCIRPIQEEEEVYALEAPDTEDLVVKHFEGIEDEIWENKETFLKGYNGAPLSDMEAKHLKEIALKGYDYKHGISPPLYNVRNRRFRRKMDPNEIDYVEKVVDMLLKQDKQAEEVSYDLVDKSELQARQERVSSWENFKEEPGEPLSRPALKKEEIHTIASAVGKQGAEEEGEEGMEEEEEEDLDLGAAFESEEEGSGAEGDKEQQQEEVGDEVDQDTGGEDDDDDDDGDIEAAGGESESDDEKDENRQHTELLADELNELETTLAHTKHKLSKATNPLLKSRFIDSIKKLEKEAELKRKQLQQTEDSVQKQHQHRSDAETANNVEEEEEEEEEEEEEDEVDEDEEDDEENDEDEDNVHEREHIQENKVVRELDEAPAEETLDQNDLDMMMLFGAEGDE
The following text describes a protein:
Function:
Plays an important role in regulating the size of autophagosomes during the formation process.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MNVTNVVKRRKKLSYFHSLLLIIFSFFLSCARGMDYYKRLGVKRNATKEDISKAYRQLAKEYHPDIAPDKEKDFIEIANAYETLSDPEKRKMYDMYGEDYAQGGMGGGSPGRGEHAHGFHFDQDVVNEIFKQFAGGGGAGASGGRAGNFHFKFTSGGPSFNHFEDEYEDIYKNEVLKINSKNIESVLNDISFSLIINFYSPTCSHCISFKKKYLKLRKKFDGYITFAVVNCQEENMLCRKYNVKSLPQLILMRSDKTYETFYGNRTDENLTYFIKNNIPSAIIECNNQKKLDNFLTQNIEIPKVLFFISHNDNIVMLKALSLEFKKRINIGIIYNTNYSVMKLFKKKNIKTPSLLLVDDIDSLSGDLTQLKNFDFNILSLKLSHIVAQNRLKNNLYGHVTSYQELTKKKYESGQCHEKDSQICFFILKLLKKNYKSFDEDIKKVANKFSSDPLKILYINIYQQPYILDSFGLSNNIQYSNGLILVAFRPKRQKFKVYDGDVNVENVHKFVDNVVSGGIPINQNIKRSLKFVHVEQYDDEL
The following text describes a protein:
Function:
Transcriptional activator. Binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes. BBF-2 may play a role in fat body gene expression. It binds the consensus sequence 5'-T[AC]NACGTAN[TG]C-3'.
Subcellular Localization:
Nucleus.
Sequence:
MEFYDGDLKDIWDSDLDPESLKISPDHDMHDWLFDRDVKDPTVILNDKLISDALLNGTQPIKTEHSYSLSSDVDSLPDSPKSLQAKIEDMDDECFPAISPKTATNGRVTIDPKYLTFHVPPTHATPISRLSSNPALNTSVADLTRSSGLQSLQAHQPHHGSGSSHVVVANLEHFQLPQHLYDNDCSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAHLQSEMLFEPKHCGLLLTASSNSNNSLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSHAHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESSVRVSRTAASITRSSSGSASASGSSTSSTVTTTRQPIHTPLISSQPKGSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLKKIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQALVSKHNVKKS
The following text describes a protein:
Function:
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Subcellular Localization:
Cytoplasm.
Sequence:
MQKIIKELSELENKTVAVVGLGKSGIAASKLLCSLGAKLIINDKKSKEEILKDLITVNGKIERIIGEGHPPEALENADIVVVSPGVPLSTPSIVSAVYKGIPVIGEIELSWQILSLIKENVKIIGITGANGKSTTSTLTYEFLKRDGKKVQLAGNIGYPMAEVVLKLLNKEIDMEYLVLELSSFQLEGIKTFKPDFAAILNITPDHMDRYSDMKEYIEAKAKIFQNQNGDDYLILNMDDENTISAIEYLRNVYLKKGKLPHVFYFSRVQNVYGAYLKNDSIYFNAREEVSDDIKKEMENTVLSVSTFKIKGIHNVENIMAASLLALCSGCKGQSIKDVVQQFPGLPHRMEPVREIDGVIYINDSKGTNVDAVKKSLESFPGNVILIAGGRDKDGDFSALKSIVKEKVKALLLIGEAKHKIADALGDLVPCYLESDMKSAVIKAKEIARAGDVVLLSPGCASFDMFKNFEHRGEVFKDIVNSL
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
KIRRTFTFWNDKGVPYQTFWQYLRVVYDLYTKPLHEVVRKNYETYGRVYGSYQGIVPTLVVGDPDLLSDVLVKDFKSFSDRTEAQKVGNEVWKKLIMNLSGEEWRRARNILSPAFTSTKLKTIFFKLYHIAGRAVTRMENAAMGEQPLAVNEVFENCAMDSTAALMYGIDLDSFGDLDHPLLHCCEKLFSSVASWQLVMLFTMPSVYKLLLPGYPPKESTEALRKFVSLMIEEKQKKQSKDDDILQMLLDTDCGEGDRKESGAKGDILGKGAMTLDEITAQALLFFVAGTDTVMSSMTYATYFLALNPQCQERVLAEIDAAVEKRGVMYESLQDMPYLEACIKETMRLYSPDSVTMRMCTNETTVAGVRFKPGMNIDVPIAGVHYDPEFFPDPEKFQPERFLPENKGNLKPLTFLAFGAGPRNCVGMRLGILQVKVALACILEHLKVFKLLKPHVP
The following text describes a protein:
Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPVHVSTSSKVLFKKVRKIVPPLLEKFHKGQHGRVAVIGGSLDYTGAPYFSSMASARLGMSSNHVICEKSAATVIKSYSPNLMVHPLLPSTDSVSNPGSIDARALASPIVSMLSRLHALVIGPGLGRDGVTLKVVTEVMKEARSRSIPFVLDADGLLLVTEDPNLVKGYKDCILTPNVNEFSRLAKALGIEVPSQAQIAAQTDESDKTSKESQACEQLSQALGGVTIIQKGPHDVISNGVTTLISDLKGGLKRSGGQGDTLTGSLGTLLAWRAAYHNKSWDSGEQENPKEAQSKQDVLAELESENKRMSPATTLLLVAWAGSGITRECSRRAFNAKGRSLQASDLTDEVHESFLELIGEPEASRTHL
The following text describes a protein:
Function:
Core component of the SMC5-SMC6 complex that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with chromatin.
Domain:
The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer.
Sequence:
MSERRAKRPKISRGEDDFLPGNIIEIELHNFMTFNHLVCKPGSRLNLVIGPNGSGKSSLVCAIALCLGGEPQLLGRATSVGAYVKRGEDSGYVKISLRGNTREENLTIFRKIDTRNKSEWMFNGSTVSKKDIVEIIQKFNIQVNNLTQFLPQDRVCEFAKLTPVQLLEETEKAVGDPQLPVHHRALVEKSRDLKQLERAVAKNGETLNQLKALVDEQEKDVERVRQRELFLTKVDSMKKKLPWLKYDMKKAEYMDAKKRMKEAEKKLDEAAKNLNSMKEPIEKQKKEKAETDSKCKKVKNLMDANGRNRCHLLEKEDEADARVVATYKELEELKKQEEHRQERILKATEDLVAAERELQNLPVYERPVAKLEELSSQVTELHHSINGKKNQKEDNEKLLSQKRYTLRQCVDKLKDMENANNKLLKALANSGADRIFDAYQWVQQNRHEFKREVYGPVLVEVNVPNRENACFLEGHVSFYIWKSFITQDPEDRDLLVKNLKRFDVPVLNYVGNSGNQKAPFHISDQMRSLGIHARLDQIFDAPDAVKEVLNSQFGLEDSYIGSKITDQRAEEVYKLGIKDFWTPDNHYRWSSSRYGGHSSASVDSVYQSRLLLCGVDVGELEKLRSRKEELEDSILFMEETHKSLQTEQRRLEEEAAKLHKEREEIVNVSYLEKKKRRELESRYQQRKTKLESLEQEEDMDASVAKLIDQASRANADRYTYAINLKKLLVEAVAHKWSYAEKHMASIELERKIRESEINIKQYEKTAQQLSLAVEYCKKEVEGKQQRLATAKRDAESVATITPELKKEFMEMPTTVEELEAAIQDNLSQANSILFINENILQEYEHRQSQIYTISTKLETDKRDLSICMKEIDSLKEKWLPTLRQLVGQINETFSHNFQEMAVAGEVSLDERDTDFDQYGIHIKVKFRESGQLQVLSSHHQSGGERSVSTILYLVSLQDLTNCPFRVVDEINQGMDPINERKMFQQLVRAASQPNTPQCFLLTPKLLPELEYSEACSILNIMNGPYIAEPSKVWSLGDSWGSLNRRRTEASQCS
The following text describes a protein:
Function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MNMVSSSKLRRAEKNTKQFTPYMDKMQDAITAVAGASSNTNHPMLRPRKITRSGYLVITSDKGLAGAYSANVLKKLITDIEAKHQDSSEYSIVVLGQQGVDFLKNRGYDIEYSQVDVPDQPSFKSVQALANHAIDLYSEEEIDELNIYYSHYVSVLENKPTSRQVLPLSQEDSSKGHGHLSSYEFEPDKESILSVILPQYVESLIYGTILDAKASEHATRMTAMKNATDNATELIDDLSLEYNRARQAEITQQITEIVGGSAALE
The following text describes a protein:
Function:
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
Subcellular Localization:
Cytoplasm.
Sequence:
MTSSHNNLLQNFQEYLSVEKGLSDNSIYSYGYDLNKFKNFLEKEHIDFLKVQADDIMRFLNEEKDRKISSKTIAREVVAIRQFYKFLKDEKKLDTNPTEKIETPEVMRSIPDYLTQDEIEELFASIKEDNLYELRDKCIFELLYSSGLRISEACNLRLNDMDLEGMTLTVEGKGGRQRLVPFGEKSLDILNRYLKQSRPFILKSRNCEYLFVSKKGSYINRKSVWRLLNHYIKRTSILKKVTPHTLRHSFATHLLENHADLKSVQELLGHIDIATTQIYTHMANKTLREVHKKFHPRG
The following text describes a protein:
Function:
May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity.
Miscellaneous:
MISCELLANEOUS: The TMEM238L transcript is unstable, and this instability is partly mediated through a conserved region containing AU-rich sequences in the TMEM238L 3'UTR. Cancer cells lacking this conserved region display decreased proliferation and clonogenicity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLLGSLWGRCHPGRCALFLILALLLDAVGLVLLLLGILAPLSSWDFFIYTGALILALSLLLWIIWYSLNIEVSPEKLDL
The following text describes a protein:
Function:
Involved in the biosynthesis of momilactone A and B phytoalexins. Catalyzes the conversion of syn-copalyl diphosphate to the phytoalexin precursor syn-pimara-7,15-diene.
Miscellaneous:
MISCELLANEOUS: 9-beta-pimara-7,15-diene is a precursor of the phytoalexins momilactones A and B. Phytoalexins are diterpenoid secondary metabolites involved in the defense mechanism of the plant and produced in response to attack (by a pathogen, elicitor or UV irradiation). Momilactone B can also act as an allochemical (an antimicrobial and allelopathic agent), being constitutively produced in the root of the plant and secreted to the rhizosphere where it suppresses the growth of neighboring plants and soil microorganisms.
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MASPMEAVARSSLVLAPRRRRALGLLPAAAAAAPFVLDCRRRHNGGMRRPHVSFACSAELDTGRRQLPSTGTRAVMSSCPGYVEGRMVGENTSQINMGWEARILRHLENPEFLPSSYDIAWVAMVPLPGTDHLQAPCFPECVEWILQNQHSNGSWGVNEFDSSASKDILLSTLACIIALEKWNVGSEQIRRGLHFIAKNFSIVIDDQIAAPIGFNLTFPAMVNLAIKMGLEFPASEISIDQILHLRDMELKRLAGDESLGKEAYFAYIAEGLEESMVDWSEVMKFQGKNGSLFNSPAATAAALVHRYDDKALGYLYSVVNKFGGEVPTVYPLNIFSQLSMVDTLVNIGISRHFSSDIKRILDKTYILWSQRDEEVMLDLPTCAMAFRLLRMNGYGVSSDDLSHVAEASTFHNSVEGYLDDTKSLLELYKASKVSLSENEPILEKMGCWSGSLLKEKLCSDDIRGTPILREVEYALKFPFYATLEPLDHKWNIENFDARAYQKIKTKNMPCHVNEDLLALAAEDFSFCQSTYQNEIQHLESWEKENKLDQLEFTRKNLINSYLSAAATISPYELSDARIACAKSIALTLVADDFFDVGSSKEEQENLISLVEKWDQYHKVEFYSENVKAVFFALYSTVNQLGAMASAVQNRDVTKYNVESWLDYLRSLATDAEWQRSKYVPTMEEYMKNSIVTFALGPTILIALYFMGQNLWEDIVKNAEYDELFRLMNTCGRLQNDIQSFERECKDGKLNSVSLLVLDSKDVMSVEEAKEAINESISSCRRELLRLVVREDGVIPKSCKEMFWNLYKTSHVFYSQADGFSSPKEMMGAMNGVIFEPLKTRGN
The following text describes a protein:
Function:
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Sequence:
MDCTSPSMLIGANWPKEILDNPLTLDGDTLSAAATETEFSHLDHHNGKRNVYKFGGTSVGSPARLCGLVQIVREERERVLAVVVSAMGHTTDYLLEAVAFAAKGDADKALKVVDKLQDLTLTNAHDTQKELEVEQVEDMTDMIIDHFKPLRELLFGICLLQEQTAAATDTVLSFGERISATIVAKLLTKAGVEAFFLDARDWLTTDDTHGCAKVFFDESKENLQALAKQWKPNTLPVITGFIARTRSGRTTTLGRNGSDYTATFVGASLGADYVLINTDISGVMTADPRIVDRAVALSHLNHHEALELAVYGTRMFHARTMVPLIKGEVTMLIRNTMDPNGHGTYISGVGRSGTRETCTTSLENLAIIEARTRILQDGSNDHQQENIGARVTKVLEELKIPVWLSIRGAHGQAISVVVPRSAEEQACAAINAELSAEIESHEVDPLNSESPVTMLSVVAEDLSKVPYNQTKFFGALADAGIEVLAVGQGTSSRSLSCVIRGLDTKVAVRRVHDAFNVDYLVTNMVLLGCNHITLGVVRQLKKQQELYRYQHKTRVNIVGFGSNCCDFLYNPKGFTFEELITRLESCKSTNAVVSAAPQPAASSTYSGAPSLEQLDQLQDLAIPILVDCSGQGNTQDLYSACIERGIHVVASNARSVCRLPPTSSRESVATTRAKTGRTFFMYTSTIGASLPVVDTLGNILRTGDRVLGIETSLSGSMNCVANEVMKGKKLSEAVGEVIRKGYCERDPREDFTGTDMVAKIVVLARALGVHLNPSAVQLEPLIPQSVLDTIAWSDDMEVDDIVAGLEAYDEAFREKYYVPAVAEGKRLHYVASIDLSKFPSIQAKIQPVLINEDHPAFFTKDNEIAFGFSSLQYPNPLVLKGSGTGAAASATGVLRDVLTILNSLNGKNVHV
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Sequence:
MRFWNSKIIHSGDEMRVRKLKVSSKTIFMLFALLIIQFSLFSGVHTAGAASEESEIDALIKGLNASDVNVKADSVKSLVEIGEPAVEPLIQVLGTEDPDIRENAAITLGKIKDERAVQPLAELLTDEVWEVEKAATDALISIGEPATEPLIEILQNENENVFLRTKAIEVLAGIKDERAIRPMIQALKEEPELQADLGYHLGLMGEPAVEPLIQLLDDEDSEVRARAAEALSRTGDERAIEPLTDALNDEDERVRLSAKKGLDKIEAQKKSMLIARYGMKREFYIEGQRQEWFEQLHTICDLSRDNMRLYFYPQGPVISYGCSIENCVTVGVLVGSEVNNSTLDNIYNIFDQAGKEIGVNDVPVVFSYEGFVQEDMETLQEMENLEITEETAGTEEYNVTEESAKDSRVSVSTPGLGAIFTLLGILISVCIINRR
The following text describes a protein:
Function:
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.
Subcellular Localization:
Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein.
Sequence:
MYAFYSLLVYIFYTVFKKEEEETLQGEHDASPDEPGPVTMETRSKRSDGHTPRMGKKACAHLSESSSSSDGDELSDEDEEDDLVKPACTPLAAFLSFKQEAEKRRTPPLQTTSLTESPLVAVMSHLLSFLEQYSHFQQLQQQADQYRVQLKRHRVQHRRQMKALRSSYRQRLRDKNNIISSLEEAVSQQQSPSPLSEGESSSNIGTPAGVHRLVESLYGLQGERSKLRGELHLLHSQLEQKEQDRHSHIRAFQQQIDELKSCIEEREEELSRLRTATGATDSEKRVLCLSAENESLKQSLSVTQGLLQQLSTIPSQSSNMLIKENENLRSRVQQLESSLQQRAEQVSQLERRSEQSEWRRAEELRKREDRMRELQLELDREKGKEPVVKYVTQTVEVESAATVKQLNKARQRNEVLAERLSNQNEHCRQLEEQIRKSDEYSCNLQHKIAAYEREITKLREELLKEIGHLEERKEEAVRAAASCSADHFQNLQDQFFTLQKRLTALPPTLRSMKTDYASLRSQVRNFSEFYGSAINEAKKQIAAAINQMSEANKDLLEKYRKEVALRRKYHEQLVELKGNIRVLCRVKPVLKEDQHEEGQSVVVAIDPNNESSLTVLTKGKGRVFELDKVFQPQATQEEIFQEIEPLVTSSIDGYHVCIFAYGQTGSGKTHTMEGTVENPGINQRALKHLFHEIEERKDMWSYNVSVSSVEIYNEVLRDLLSKDGEKLDIKINPDGTGQLHVPGLRVIEVNSFQHIKKILATARRNRITFGTQMNQHSSRSHALLCITVQGTDLATGSKTTGKLNLVDLAGSERVWKSGAEGERLKEAQNINRSLLALGDVIQALRARQTHVPFRNSRLTYLLQDSLGKGSKTVMVVQVSALESNVGETLCSLKFAQRVCKVELGPAARKIESGVGQCD
The following text describes a protein:
Function:
Transcription activator that acts as a flowering master switch in both long and short days, independently of the circadian clock. Promotes flowering upstream of HD1 by up-regulating FTL1, FTL4, FTL5, FTL6, EHD1, HD3A and RFT1. Seems to repress FTL11 expression. May recognize the consensus motif 5'-TTTGTCGTAAT-3' in target gene promoters.
Sequence:
MSHTSEEESLSSFQQQPKLEVGAAGPSRGDPAAMPVVKKRRGHPGNPDPDVEVVALSPKTLVATNRYICEVCHKGFQRDQNLQLHRRGHNLPWKLKQRSSTDAKKKVYVCPEVTCPHHDATRALGDLTGIKKHFSRKHGEKKWKCERCSKKYAVQSDWKAHTKICGTKEYRCDCGTIFSRKDSFITHRAFCDVLAEDNSRVNHSLATMVGSLHGQHDMYSHGVPSPTDMVANMSSNDHNSDMHLRSLSPYALITRNTALFSNQIPPKDPGFPLDGSASGYPYMSMNSPYMSATALLQKAAEMGAKTSQDPISPLLLKGFANNFTSARDHMGISSGSQGDSMGNSAANSVCMKAAEDESMNGHNNILINSAWTSGMMTPTTVPLIGLMNNPFSMRQEKESPQIMPDIQTQHNRQENISEVGDAGLTQDFLGLGGNGNLDISSGTYNTDVTALSYSDDQQKNQEQMYSYHESSLDSTALDKPMWDS
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MSRKSKHRIHHITVNKKSKTGRRRQYSDERELFREDYVVKKPCNPCPKQVNMKPREPQPNKYDEEQIKELVKLAGENQQLLNEMTLDARITKAKQKKTDSIVKTFDIWGTPLPEKRTIDFTGKPIPVPHKLSARVPGVDELQGKGSSAVELPQTAVSYNPTYLSQQQVIEKLAKKYVSEDKVAMKLKAIRPSSFTPEEVHEEHVNAILQYIIERDKAQAAQPDQQDGHASEFDASEQSLSVADTAASRLPLTDEIRRLLEEHKLEEVHMTQTDRRLKRRQIREMSQELKVLDELIKQVHISKLAASIDAGTFDINNLANQSIETELGRIEKKIRQPTDRPVPEEEPPVPLTEDCKGTMRLVKPVGSVLQDRWVSAQRRNLVEIGVPNNPNKQNATREWKVIVH
The following text describes a protein:
Function:
As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding; In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP; Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane. Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.
Subcellular Localization:
Cell projection, neuron projection. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Postsynaptic cell membrane; Single-pass type I membrane protein.
Sequence:
MLMRLLLPWSYLKYSCEMPVYIFSFSLLYSCMNGCKVKQVAWKARHMLLFTKALRTYPTKHSALALCTDPLNPWLLNCCCFFSFWEHKDGEGRGQCVDSWGRNSNLCCFDSLGEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTSVKKSHKATVHIQVNDVNEYAPVFKEKSYKATIIEGKQYDSILRVEAVDADCSPQFSQICSYEIVTPDVPFAIDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKRRAAEDVLVKVSIKPTCSPGWQGWNNRIEYEPGTGTLALFPNVHLETCDESVASVQATVELETGHIGKGCDRDTYSEKSLHQLCGAASGTAELLPSPSGSSNWTVGLPTDNGHDSDQVFEFNGTQAVRVPDGIVSVNPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKKYKPAEFHWKLNQVCDEEWHHYVLNVEFPSVILYVDGVSHEPFSVTEDYPLHPSKIETQLVVGACWQGGDLHMTQFFRGNLAGLTIRSGKLADKKVIDCLYTCKEGLDLQVPEDSSRGVKIHTNPSQLALTLEGDDVGELDKAMQHVAYLNSRQFPTPGIRRLKITSTVKCFNEAACISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESPEGVFLFPELRIISTITREVEPEGEGDEDPTVQESLVSEEIVHDLDTCEVTVDGEELNPAQESLEVDMARLQQKGIAVSGSDLGMVFTGVDTMASYEEVLRLLRYRNWHTRSLLDRKFKLVCSELNGRYVSNEFQVEVNVIHAASPMEHASHMAAQPQFVHPEHHAFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEHGDQQNVNRQQQLEWDDSTLSY
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKAGKQEQRHFQVSPSHKEPMGMWEEASDTGMKGKKKKKDKNEEEEEERGKKERMVNLTLEMIYLLTGETLENLIKDTARITEQMKETLQQLSSDGENNSKVDVQSMMPCNDEPRTNVSSTSAPKTCVSSSTNTENYPTNDIKDESDSWEGGNQSDCSIAPQIQGTETAAPILESSSAADALSHGIKEELAEWEGAELSDYNITRVAEEQETDALSPIMGCNPNNNLSDDFKEEPISWEEGNHSDSSMNPLILAQGIDTSVSLSAWSEINEYGISINTKPTFTSPPSTDSMQGMYNCYKPFQSKTSLHEHQRKSRRKEDPSSPPDCGKSLVHEPDHKIPQNNRSEEKRFTCSDCGKSFKQRSKLYIHCRTHTGEKPYACSVCGKRFIQVQELTIHYRIHTGEKPFSCSECGKCFTQCSHLSMHRKVHSGDKPFSCAECGKCFKQRSDLHKHHRSHTGEKPFACTECEKRFLHRSDLTAHHRIHTGEKPFPCSECGKSFAYRSALKRHERGHAGVKPFACSECGKFFRSLSDLHRHYRCHTGEKPFSCSVCGKCFRRCSALTSHLRKHTEQEAHSPNANVFDKDASWTLQTSLPNKNSDQKV
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAAHLKKRVYEEFTRVVQQQPLEEPSAKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDTSVRLKIASLLGLLSKTAGFCPDSIVDDVINTLQNEKSHQVLAQLLDTLLEIGLKLLDIVSHRMRLVDVACKHLSDTSHGVRNKCLQLLGCLGSVEASPAKEVENAVAKDVQKIIGDYFIDQDPRVRTAAIKAMLQLHERGLKLQQAMYNQACKLLTDDYEQVRSAAVELSWVLSQLYSESIVPIPSSNEEIRLVDDAFGKVCHMVSDGSWVVRVQACKLLGSMLQVSPHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEELDTGAVNLIDSGACGAFVHGLEDEMYEVRIAAVESLCLLARSSAPFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISDNITLREDQLDTVLAVLEDKSRDIREALHELLCCTNVSTKECIQLALVELLKNLSKYPTDRESIWKCLKFLGSRHPTLVLSLVPELLSTHPFFDTPEPDMDDPAYIAVLVLIFNAAKCCPTMPALFSDHTFRHYTYLRDSLSHLVPALNLPSVRWSWIPDVITEAPPEDPSQQFLQLSLERVHNLQHLGSQGTQELLEFTIRDLQRIGELQSDLAGMADFSATYLRCHLLLTKALNEKLWNLAAPLFLKNSLTTNAVKQILEETYKMEFMYSGLETRQVAIIHHMRLQAKALQLLVTARTTKGAEPLFGMCEEFLQEVDFFQRCFISELPHMQDSFVDKLLDLVPRLVNSKPLEMVKILQTTLRQCTFLRLTLPEQIHRASSHIIEPAEESDNPIRFTSGLVVALDVDATLEHVQEPQSTVKVQVVYPDGQVQIIHPKPADFRNPGPGRHRLITQVYLSHTAWTEPCQIEVRLLLAYSSSRSKVMSRASNSTWGESTETVPSTESSTEGTIPFSKPVKVFLMPKPARR
The following text describes a protein:
Function:
Putative FAD-dependent oxidoreductase.
Sequence:
MAPKPRVLIIGGGFAGVTLAKKASAFADVTLVDSKSYFELTWTTVRGIVDPEVASRSAISYKDIPGMGRFVQATVTSLSAKSAVLSNGETLSFDYAALATGSSYSDTAFKSTASSSREQRLAELKALTEDIKASKSIVVVGGGPAGVEVAAEIVEAHAGKQVTLVHPGAQLLNGTPPKAGAAAKKWLESHRVTVLLNTSVQGKPEGRGPVSLTLDGKEGRTLAADVVLWCAGARPNTAFLQGGELAGCLDERGAVKVLPSLQVEGHPHMFALGDVNNVPEAKLGYLATEHGKLVAVSLKALISAKPGASPKLGAWKPGMGNQVMIVSLGRGDGVCRMNGNVCGGCLPASIKSKGLFVDDYRKQLGV
The following text describes a protein:
Function:
Probable transcriptional regulator.
Subcellular Localization:
Nucleus.
Sequence:
MDGYQNFLPIPPENNTWLLLLDDFSQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQFPQQYTNDGINVQSIESNNYLNNNNFNFNERLESLQKQQQEQQTQIQQQLQNYQQQYQDQYQQRQQQYQDQYQKPYELPSQYIDQCNQIFSNYNNNNNITSINYNMNNNNNSNNSNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKTTDNINNVNSINNLNNINLGANNVNNNVNSNVVSNVNNNAISQNKPIFPPFNDNPINIQQQQQQQQQQECYKIPQYKISLDNTNNPIITPTITPTLTTFPTITPTLITPTTIAPITPTPTPTPILTTTTTKTTKINLEETNEKTKIINETKKQEKSTESIKKMNQNKASRNYRQKKKDYIKEIEDKLSLLEMENSKIQKENQTLRKTGSVDLMKPSNDIMKMMTDCKTITNQLKLSLERNDDRSLIYLLHQYHRVIEERYSHIEYEAEKVANPYVQLRLSIVGYTPGQFCPFVLNIFNDNNDDGDNQKVTNDHNWYNTFKKEANITPEQSNKLDSIRFQHTKVSASMFKEIQMLDLEIKSFFYKFIFSYPSDPLSSLNPTELVYNSTTTTPIDSYSLPAIDKQLELAGKLESLKNKLTLNGGLMLDTFSSISSLLTPRQEAIFLVGVDPYAFINFSHFDIINDVWSNIINKPFSGPVHMAQSLNKMFNHS