lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Chromosome.
Domain:
The CXXC zinc finger mediates binding to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides; The JmjC domain mediates demethylation activity. It is also required for repression of ribosomal RNA genes (By similarity).
Sequence:
MEAKKDSARRLRSIDRTRYAEHEDLSDVEDMVSIRGFSLEQKVSCNAYRGNFVRYMEGKDFTYEYVQREALQTPLLFSTKEGLGIKMPEQDFTVRDVKLLVGSRRVVDVMDVNTQKSIDMSMSQFVRYYETPEMEREKLYNVISLEFSHTKLERVVKRPTVVDAVDWVDNMWPRHLKEQQKESTNVIAEMKYPKVKKYCLMSVKGCYTDFHIDFGGTSVWYHVFRGGKVFWLIPPTGHNLQLYEEWLLSGKQTDIFLGDRSEGCQRIELKQGQTFFIPSGWIHAVYTPADSLVFGGNILHSFNIPMQLRVFEIEDRTRVNAKFRYPFYYEMCWYVLERYVCTLTKRSHLIKEYQRESMITDRKPSLDSHSSDSWLEMEEESCDIHIKEEKGNLVEKPSKQSGDESSTTNSTHSNGKDAAEKKQKATLMQQLKRTLSNDSDESSKSIVHSDFPKTPTGSPATDMPCKLTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEDMKTVLKEHADDDNNLAISGVPVVMWPKKPSKNRAVGRPKGKIASSPAVKLSANRTSAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDCVEGQEAKFNVMLMECSICNEIIHPGCLKTKESDGVVNDELPNCWECPKCNHAGKTGKVYKQKRGPGFKYASNLPGSLLKEQKVNRDNKELTEIVKKKVEREETPKQIPEEQPKKKPTEGIIKKKPEDGHVRKKRKFEKPPDPSVRKRLKLVKEEKLLRKKRRSWKTPDERAMMAKTLRRIKQEPDDDLTEAAPKAKESDQSRSSSPTAGPSTEGSEPKEKKKIRRKRRVSNKELSKELSKELNQEIQKTESSLASENHHPIKSEPESDNEESKKCISTNGERMHNFSKGLNGTPKELRHELFPSLKTTPRANNRPPPSLSPPKCMQMERHVIRPPPISPPPDSLPLANGAAHVMQREVWMAIFSYLSHRDLCICMRICRTWNRWCCDKRLWTQIDLNRCKSITPLMLSGIIRRQPASLDLSWTNISKKQLSWLINRLPALRDLNLSGCSWIAVSALCSSCCPLLRTLNVQWVEGLKDAQMRDLLSPPTDNRPGQIDNRSKLRNITELRLAGLDITDASLRLMIRHMPLLAKLDLSYCNHVTDQSINLLTAVGTSTRDTLLEMNLSDCNNVTDQCLTFFKRCGNICLIDLRFCKQVSKESCEQFIAEMSVIVQFGQTEEKLLQKVS
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.
Sequence:
SVNVLINLISPLEVSKISLNEDSFQIIVDEHVHTVSCKNLKIVVNSLSSLIVTQTYISFRFATVNSSDDWGSFKTEVLKTAGSNVPTNLQNIFLKVAVPYVLQCKNCSQNLSENVKFERVLPLPSENSDSSDWFCHSHGGSNVAVLNPKETDVFYGSCYCHLSKPLVRNVIESEKVVVCKRCLSWLGLLKISETFKFWFNTVAFKDGSVVHSTSPLGDTFAALREVLNSILFNTAKIVLCCQSGKKQNDYILLWILEKQLNVQLGVKDCKVAKVLFKYENNKNEIVKKWMEDSNVVSIDISKPMTVELLKHLYKFNKIFPKEFSESNNFYISYLMMYEHGEK
The following text describes a protein:
Function:
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSNEQNEEVVECPLCMEPLEDDLNFFPCQCGYQICGFCWHRIRTHENGLCPACRRDYGFGFQKGSELIIISTTYSEDVVKFKPLSEEQLSDKGLTLIKSMKKDKKKKDHQKKQKQDESRKHLEKMRVIQKNLVFVVGLSPRIATEEVLKSKEYFGKFGKITRVAINSNTSYAQSQTPSLSAYITYTRNEDALEAIKNTSGLIIHGRTIKTSHGTTKYCNYFLKNIPCTKSDCPFLHELGDESCVFTKDDVQQRSKDLISVRVISEQISTKVVTEVSENYEEELEMKSDVQVEKPTKGTISQNSYDKAVGSGAPNKLYNPPYMNIRATDAVPSHVNLYANNTDEDLDFDPWNESNKGFADLLLLGSNNNVNNKLPVTVEHERNGNLYENGTTSMLGNTYSNIVDSLDNTNTEMASGNPYNNTGYANRKQNIFPQSNQSYFQNAQNYAHFGNYYNPGDGFNMSKYIDSSSNNIDAGSSYSNVGIDTESFGIKSGFEGNSSSANNFGGAKVPNTAIKAEHNDKNTSTPCVSNNGMLQNVREWQAGFRSLLPNVNITFGFGNTLQGTEISGKDLSHKENDDQSKPHHIMESDVKHGIESKSKILLNIGINDCFMCRDEIGNTENPSFIKTEETVVPVNKMKEMNIKHEVEDITGNKYRIHANKNDNVTRTNYLPSVNSQLGDRKLAQSYKHKHKNNVKSGIRSNVYPNSPGRDRASNTLPARKAENRNQSYSTNTNSTKAPKLLQTEADTSDDKSSKVRIVKKDWKTNVDVAGTAIKPKTNVINNNVPSKAHETKGKDDNDIDETDNKVIKSLSKNKKKRQRKLQSKKPTDDNDLAKSEIATYVKSTTESLNLGFLPAKFSESIAVDYDKDTDPDTIVNHLEVEIENTKKEVQDCEAKLHAVIRKNCSISNTNYEKSIHNQE
The following text describes a protein:
Function:
SNARE required for protein transport between the ER and the Golgi complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MSATVVYSNAIKLKTELHHFISTLDSGQGSPALQSKVRAGLNNLQRSIDDLEMLSRREVTSVKREITSGRASTLRDEHCQIQSAFDRYCSIESARIASEQRQELLGLDNSLQQRNSGANHFNHPEEQSTILMMDGLINERNVLEGAEQSIEQYLTMGRNALHELYEQRSMLKSTQKRLLDVANSLGLSSSVIRFIEQRTAADQWILYGGLAGTCLILWAIVHYFG
The following text describes a protein:
Function:
Functions as a transcriptional repressor for PRDM1.
Subcellular Localization:
Nucleus.
Sequence:
MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELAEFEIGASSSSSTEALISAVMAGRSISPWLARRTSPANSSGDSAIASCHDGGSSYGKEDQEPKADGPDDVSSQPLWPGDVGYGPLRIKEEQVSPSQYGGSELPSAKDGAVQNSFSEQSAGDAWQPTGRRKNRKNKETVRHITQQVEDDSRASSPVPSFLPTSGWPFSSRDSNADLSVTEASSSDSRGERAELYAQVEEGLLGGEASYLGPPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPRGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGSRRHGVCTDCAGRGMAGPLDHGGGGGEGSPEALFPGDGPYLEDPEDPRGEAEELGEDDEGLAPEDALLADDKDEEDSPRPRSPPGGPDKDFAWLS
The following text describes a protein:
Function:
Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.
Miscellaneous:
MISCELLANEOUS: Present with 638 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MVLETLKQGLDSSQIHEALIQLDSYPREPVDLDASMVLIKFVIPVYPSLPERSKVILRRLASKSFTFLCQIVTFSRTISGRDGLQEIRIYQEILEDIISFEPGCLTFYLKASTTSKADRDSIKALFFGSKLFNVLANRIDMAKYLGYLRLQWKFLLESNETDPPGFLGEWLVSSFLLNPVLAADMLLGELFLLKESYFFSFQKIISASSLIDQKRLIAKFLLPYIQVIVTLENLNDVRKILRRFDLDKIISLSVLFEIQSLPLKEVIVRLMSNHSSTKFVSALVSKFADFTDEEVDTKTCELLVLFAVHNLNHSQREEIAHDERFLNGVTKHLGSNEREARERAMFIAKLLSGGHLKYESDFKINIPNVKFESNSDDKIIDFQSLKNPSICNTQTDVGKDKITEVSGHVQSLTLDCSDSDDEDENDEREIVKRIVFLKDLMKEYEKTGESRKAPLIPLLKQTVKLIRQKADFQLEVGYYAQGILSSIVCLNNEFDEPLFEQWRINALTSILVVLPEKVNGAINILFNSELSLQQRMSLLSALGLSARELRGLDDPTIVKPKFDFPTNRLPWDDQSHHNSRLVEVQESTSMIKKTKTVWKSRKLGKDREKGTQNRFRKYAGLFFYPLAHGWLNGIDVGTYNQLFKSHYLTTLRIIYSCANPVHDFESMTELMNHIISSAIEEGISLNKG
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MHHPLSGEMEEFFEDSEIFVTGGSGVVGKALVEKLLRSCNVRRIYVLLRPRKQLTAEQRLVRLRQATVFHVLAVQKPEELDKIVAVPGDVSLPGLGIDPSMMQRMKGVSLVYHCAATVRFDEPLREAVRLNVGGTLEALKFAETLPQLRAFIHVSTFYSNPYLTRVEPKYYSSPMDWRLCLRMIDDVADDGMLNALTRKLIMGFPNTYTFTKNLAESLVNDYRHRLPVIVYRPSIVLFAVEDPSPGFSPSLMGAMGLFALVGAGILKTVYLGKDIRLDITPQDIGIKSMLCYTKMGYDIYRQGPPADLPVFLSSSCTHVPHTFTQIAEQMDTLDLWRDVAFEKNLMIPGCHYTDKRWAYQFLVFTKQILPALILDLLLRIFGQKPVLMSAVRKAYQTLEVMQPFMFNNWDSPGVSDMETLSKHGEGSAFNFDAFNHPDIHGLVIQSCSNMLHSIRTHLLREDPKTLERSKRILRIKVFLYRLLRLFLLYKLILWLWRSYLAHLF
The following text describes a protein:
Function:
Neurophysin 1 specifically binds oxytocin; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).
Miscellaneous:
MISCELLANEOUS: 'GKR' has been placed at positions 10-12 by homology with the complete sequence of the other precursors.
Subcellular Localization:
Secreted.
Sequence:
CYIQNCPLGGKRAALDLDVRKCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCLADPSCHDEAAFSQ
The following text describes a protein:
Function:
Transcription factor that binds to the site II motif (3'-TGGGCC/T-5') in the promoter of PCNA-2 and to 3'-GCCCG/A-5' elements in the promoters of cyclin CYCB1-1 and ribosomal protein genes.
Subcellular Localization:
Nucleus.
Sequence:
MDPKNLNRHQVPNFLNPPPPPRNQGLVDDDAASAVVSDENRKPTTEIKDFQIVVSASDKEPNKKSQNQNQLGPKRSSNKDRHTKVEGRGRRIRMPALCAARIFQLTRELGHKSDGETIQWLLQQAEPSIIAATGSGTIPASALASSAATSNHHQGGSLTAGLMISHDLDGGSSSSGRPLNWGIGGGEGVSRSSLPTGLWPNVAGFGSGVPTTGLMSEGAGYRIGFPGFDFPGVGHMSFASILGGNHNQMPGLELGLSQEGNVGVLNPQSFTQIYQQMGQAQAQAQGRVLHHMHHNHEEHQQESGEKDDSQGSGR
The following text describes a protein:
Function:
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity).
Subcellular Localization:
Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells. In a minority of cells, homogeneously detected in the ER lumen. Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium.
Sequence:
MRATDRMGARAVSKLRLALLFVLVLGTPRSGVQGEDGLDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEEDSVYVFKGDEVIEYDGEFSADTLVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYFKSKDSEHYKAYEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPDKPNSEEEIVSFVEEHRRSTLRKLKPESMYETWEDDLDGIHIVAFAEEADPDGYEFLETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSIWMEMDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDDDDDDDDDDDD
The following text describes a protein:
Function:
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate, which would allow P.denitrificans to grow on t4LHyp as a sole carbon source. Also seems to be involved in an alternative catabolic pathway that degrades trans-4-hydroxy-L-proline betaine (tHyp-B) to alpha-ketoglutarate; this pathway would permit the utilization of tHyp-B as a sole carbon and nitrogen source.
Sequence:
MTQYIFPCIDGHTCGNPVRLVAGGAPRLEGATMLEKRAHFLREFDWIRTGLMFEPRGHDMMSGAILYPPTRGDCDVAVLYIETSGCLPMCGHGTIGTITMGIENGLIVPRTPGRLSIETPAGKVDIEYRQEGRHVEEVRLTNVPGFLYAEGLTAEVEGLGEIVVDVAYGGNFYAIVEPQKNFRDMADHTAGELIGWSLTLRAALNQKYEFTHPEHPQINGLSHIQWTGAPTVPGAHARNAVFYGDKAIDRSPCGTGTSARMAQLAARGRLGVGDEFWHESIIGSIFKGRIEAAATVAGRDAIIPSIAGWARQTGLNTIFIDAERDPFAHGFVVK
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.
Subcellular Localization:
Nucleus.
Sequence:
MHLYQLEDELKKNVFCREDQIKKLSCLLFNKDCRVPSIVLYGVASTAKTFLLRTAFDLSKEENVWINLQDCFTVAHFWYRILIKVGVDKDIALKKGINISGFIYLLEQAMSKRDYHTFLVLDQIDDFAEASTILFSQLAQLPIVANIPNLSIIFVLHSHPAQYLGTLSIAVIFFPQYTQAEILEICQKTPPNLDFLDRSGDSVFEDEIELSVWMQYCSFLWSVFGVQCLNDYRSFRSVLDRYWPKFIQPIVEGDIHPADYAQLHKLAKNFLVSDATVTKRLHIINPTEIKNLLDSKSINLSLVSKYLLVSAFLASYNPSRLDAQFFSFSKTSKRRGRKRKQIQDEGVLFSKIPRTAGSKGRSAVKISQLTLGPKPFEVERLIAIYYAISSPVEKVLTADVFVQIATLASLKMILSASKGVLRSLDSPRYIVNVSREYVLKIADSLSFPLDSYLAG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Sequence:
MDVMVDVYTVECLYKRFGCPTSMAYHSVADHAASCRHAPCYCFDCRFDSSPVSLVGHLTARHSWPVEKIQYEVAKSFVVPASEEDKRRLLVAEDNCVFLLAVGAGRDPGGRRPVNVVCVRGNAKPLYTGVLWVDGPPAAPGQPLTSSFQLKATVASCSVPGEVDMEQGWLHAHVDPNMMHGESGELHLRLCLTKLS
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein. May be involved in host intracellular survival after infection (strains H37Rv and CDC 1551). A role in the SOS response is controversial; it has been seen in strain CDC 1551 but not in H37Rv.
Domain:
The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain 2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity); The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA (By similarity).
Sequence:
MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAENSGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFAGKSSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPDVTDDPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTSTVAVNSLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTAEAIWEMPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVHLPFQLHVLDMAADRVSHVVAFLDTTLFPKFGLPDSL
The following text describes a protein:
Function:
Regulator of RHO1 signaling that acts as a cofactor required for the efficient localization of the TUS1 GTP exchange factor (GEF) for RHO1 to the bud neck during all phases of cytokinesis. RHO1 is a key, essential hub protein in the cell wall integrity (CWI) pathway in which activated RHO1-GTP binds directly to and activates multiple different downstream effectors required for cell wall synthesis and actin assembly during cytokinesis (Probable).
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Sequence:
MTHPVISLKPSYNSVIRGCPGLPDTLPRIECQLRVRSNNSLPFKLVKIEIVLKTIEIYFNKNLYSSNNSSFTPFNRPSDPSNGHSDTSNQNISIHYKKNIVLSHPTHDGDDLNNDLIGIDIPLTIGLPDDIKETNYNPKFGKTQTFLDCTVFYTEVGGGSSNKKRNFLYPVNVERYTYLPSPSYFRPINRSNITSPDQKFLISYSIENPCVSMNNDTLKLSISIRLNPFPNNATTPSSNDFDVSTPTLFSTKKKFKSKLKLKSITTQILEYLEILKNQSEFSSTQTTNILQTSVRQVDQIISMNSMIFQFNLKIFTKDKILQSFRSSESSCPETKVLINKIDDIPLQYHSSITTIGQHFNVSHYLSIRFKFNKSLKNFEINHPLIISFWSVSQLPLIENLILQERQTAKFAKKFYKNFGRIKNTSNNNNSSNCLEYPSLPPIIYNFNDPETNNRFNILYSQKDPSRTDPSKLRRVPVIQ
The following text describes a protein:
Function:
ATP-binding RNA helicase which may be involved in the ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MVKPNNVKIKNKGNLKKSNESQNDYMKGKKLETKSYQKALLSKNSNNNNDGAQAKRLKKKEEFKKKLEKRQNTIVIKDKLKEPSTFLKEDQSFFDQNIFNDQDDYKHQQMNRININENFETNLFGDMMNEFDGDLNEDLDLLDYNDEVIDNSNFDNNGDQFNSEDEEFYDDEKQAKKSNKNKNADADNKKSKKSNKKEEIESSEKFESFPMDENNEQEEETTSKKKKKTGGFQSMDLTKNLLKAILKKGFNVPTPIQRKSIPMILDGHDIVGMARTGSGKTGAFVIPMIQKLGDHSTTVGVRAVILSPTRELAIQTFKVVKDFSQGTQLRTILIVGGDSMEDQFTDLARNPDIIIATPGRLMHHLLETGMSLSKVQYIVFDEADRLFEMGFNEQLTEILSKLSENRQTLLFSATLPSLLVDFVRAGLNNPKLINLDTDTKISENLSLSFFTLRHEEKLGVLLFLLKDIIYKKPQLPTTETTTTTTTNNESNQQQQKKSSTIIFVSTKYHVEFIHILLERAGIASTYIHGYLDPVARKINLAKFRSHQVGVMVVTDLAARGIDIPLLDNVINFDFPPKEKIFIHRVGRVARAGRSGIAYSLVSPDEVPYMIDLHLYLGRKFLNKFQYEGQTINDPKYSFYGTIPQTIIDRETEFVNVQRKECIELLSLTKTIHNAHKKYLSTRPGASHESNRRAKLMDKSKYHPMLSDHLNSNDQIRNDFIQSLKSFRPPQTVLELDARKNNVQVSIMKDKRKVHTNVIESQQKKLYLQQSETNLGPENEEFDYSKLDTRKRLLQLTENITEEMLRSNKSNDNNDNNKDIKMNENDDENDDDDEEGENDDDEEEENEKDEDDEEDENKNKFNIKIESSDKNDNNKKKLKSRSSSRDPNFFISATPENLIQERAMSISNRFTKDDEVNLVADTDRKQKKSMVWDKRKGKFVSSQADADRKNSKKLVRNEAGKLVEAKKSHKGYEEWKKKTHGRIQRVGEDENSKYQPNQKEYLPQKWRGQGREKEKKDNKASHAKGSHGLKGRPSELKDKNQISKNRSEKERKMRVNKTKGNPKGSKSKSGGGGGGKGSKFGSGKSKGGKSRK
The following text describes a protein:
Function:
Possible regulatory or functional link with the histocompatibility cluster.
Sequence:
MELEQARREAALHARRREELDTLKQQRKERDKTSVTANFSGKQKKQQLRARKQRLASRRDEEAAQNLQSAQYEAFYADKPSAIEKEDADDEVEAFHAEPDFFARNNDLDNDLSSRLKLTVALGKNNKDTVGKELSSFFVKETKEQIQLRLMEGQRPLDLAKRETPLLATVSGRDPILDHPKRPKWTYMDNNESLMFDQWLTKIHDKYDNEHLNHFEHNLEVWRELWRVTERATHVVVVADVRNPLLHIPASVYDLVTKELKKPMVVVLNKVDLIPTTVVQLWKRYLAGKFPLAQLVCFSSRSNAVHGDNDVSTRRRVLSKKLEVGDASAVKGAVDILVACGIDSAEAQQLAEELNASLSEQETLQQQFDAVQEKKKAGGKRRTCMSCTSGSRPSKADANVKDESDAIARGYLLCARCDREEHTELKGHFQIRLQSALAAVSTDPTVPGSAGAIGQANTPKVTIGLIGHPNVGKSSVLNALAGKKIVSVSHTPGHTKRLQTILIAPEICICDCPGLVFPFAGVPKYLQELSGLYPYSQIREPYSAVRFLADHVVLESILDLKPRTQLFDGLEEELEWTPWTLCEAYAEKRGYRTDRRGRPDHQRAGSELVRDTVDGILPLFFLPPDYTGKDITPASIAKYCEEEDALLKAGDEGDADADDEDEEDSSNEEDEDDSSAAQPAKRKIQQSEPANAFSLLDSDSSDEDSEEED
The following text describes a protein:
Function:
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Involved in the expression of nuclear genes for components of mitochondrial complex I. Promotes cytokinin-mediated leaf longevity. Involved in the ethylene signaling pathway in an ETR1-dependent manner and in the cytokinin signaling pathway.
Subcellular Localization:
Nucleus.
Sequence:
MVNPGHGRGPDSGTAAGGSNSDPFPANLRVLVVDDDPTCLMILERMLMTCLYRVTKCNRAESALSLLRKNKNGFDIVISDVHMPDMDGFKLLEHVGLEMDLPVIMMSADDSKSVVLKGVTHGAVDYLIKPVRIEALKNIWQHVVRKKRNEWNVSEHSGGSIEDTGGDRDRQQQHREDADNNSSSVNEGNGRSSRKRKEEEVDDQGDDKEDSSSLKKPRVVWSVELHQQFVAAVNQLGVDKAVPKKILEMMNVPGLTRENVASHLQKYRIYLRRLGGVSQHQGNMNHSFMTGQDQSFGPLSSLNGFDLQSLAVTGQLPPQSLAQLQAAGLGRPTLAKPGMSVSPLVDQRSIFNFENPKIRFGDGHGQTMNNGNLLHGVPTGSHMRLRPGQNVQSSGMMLPVADQLPRGGPSMLPSLGQQPILSSSVSRRSDLTGALAVRNSIPETNSRVLPTTHSVFNNFPADLPRSSFPLASAPGISVPVSVSYQEEVNSSDAKGGSSAATAGFGNPSYDIFNDFPQHQQHNKNISNKLNDWDLRNMGLVFSSNQDAATATATAAFSTSEAYSSSSTQRKRRETDATVVGEHGQNLQSPSRNLYHLNHVFMDGGSVRVKSERVAETVTCPPANTLFHEQYNQEDLMSAFLKQEGIPSVDNEFEFDGYSIDNIQV
The following text describes a protein:
Function:
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MIVLTQVAIPTENVFCKQENCKAVLNHQDYGTGTLYIAASMLTWSNNEGNGLNLEYPSISLHGVSKDLSVYPHPCIYCMLDLQLKDENGDEQSVGELILAPEDEASLEDIYNAIADCQALHPDDEDEDLEDALNIYLITVEEEDEDINEEGNGTSSVDMPSQQEFQHMIEDQSTSGYQDGNMVSTEQSNQNNDGQFDDADDH
The following text describes a protein:
Function:
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion. Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons.
Sequence:
MRKYVLFFISGNNDSQIWATTPNTPRVIARGGLERNIHTRTLARMVNEDAPGTSTPAAQSRLQTTASPFHRTHLTQMCRRGDTNASLLRDFTRMIRDTPRNFSKNTQHGNDRDFGDLERDPDVDLLLSKVCLECVYVEPKEGAIPKANKIFISNFLSDMYINLVSVTGEVMKIIPIWKNAETTRKNLLEKGKHEPCVVDCVDAAFVMKSGITVVLGSDFTTAMFGGNERIAPIFIKEMSNQRVGRKFRLFSFAENRIFAVNEMRCIVVEIPETVTCKSATELMRTCFLHLDRDLSRKLLIKWRSVKRDVDTERLDLDRKEMIDVAIFMLDNVGVRVTNVVAQERADSPEGHGGKQMRPRMSDSEVLSMMRQFFEEMTFRPKSEVITEDGYKCHLSVELDPNGEGFVHTQDLLHAFHSQCEDWSINTMMHSILLELIPYAYLLAKVMNYRAFEEYYVQLFKHLLSQIAIEFKIPPEIHEKFVGAIHIPKPCWSLNNVIAHIICERTTPETMESIPKFISKSSVRLLTILAVGRKFIGMGTNIDMDCERWLGKDWKRRIGLSGDILKSFRRIMNGKSSNSAGRASQLIELFEIGSITIDFMVLAVKVLMLKFQTDAFAGAQSIEPKKCIYATADEMISIAHLRWKNDIRMHNVQLMLNSSRPILIATNILRKNEDDNMKELQDRFLTQTSYRTFSQPFGRAFLDFRTAVPSLLTSIYIPRLNVGGMIYPSRVTCDPPTTEIFKLCTEWGNFYNSLASALRIGSSETVRIDNEWIVMVSKNIKSTAVIGGMTLGFGLNGHLAPFNMYHAHQMLSTFDKFHSVALLIGLSASNFTTCDVQIHKILATYLSFLMGPTPLEIKLDFTIQTAAISGLGLLFADSGNMTIAKKLVNEIGRAPNRDEEPVTDRNAYKLSAGFSLGLIMLGKGNGSASTVIPFKQNIPPMSQRLIYMMNGMRRDKCVFLPQVAPPVVNDVPNLPFSNGGMMTSSQVANHVKESEYINIHQSAEPAAIALGMMFMKMNNEFIANALALPGTITELERLKPDSMYSRVLAQCLVMWDSIEPTHDFVKSLIPPVIREYATAALHFGVPIRRDEDGEEVHEAINDAEEKYWAEIVDKGTVSQTFLYAVSAACMAIALKFSSCGGPNEKNIVNTAFRIIEYYTKIVMPDGKSNKDMGSIRMCIYSGAYTRTSCLSMLITAMAILRVGTGDLEVMRYARLLRLCDKPESDWIATGKKHFEQMVAHQALGILMLGEGRYAFKKDDLSIALTIISTFPTIPQSVSDNSHYHQPLRFLWSMAVEPRLLVPFDIAESCVVEVDVTIVMKPKDGNEPIVYKEKAPYLLPPLEDLQSISIGGGNYQLVHISLQSEDQVKVMKDIMTIGQGRVMLKRYGVDSSEMKIKEATTLYDDTPSLMSMFNNEDTAVELDEYEIQCMMEKIDEGINLNSSDEYPNVQIELSCVRDVTERTTMDLAQLQKRSLKLLSESLDLWQDEVNVSNTINGLADAVQDMQI
The following text describes a protein:
Function:
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach (By similarity). Binds to cobalamin and to cobalamin analogs such as cobinamide.
Subcellular Localization:
Secreted.
Sequence:
MRQSHQLPLVGLLLFSLIPSQLCQSCVVSEKDYSHLRLLISAMDNLEQIRGIYGASILLSQRLAGIQNPSLEEELSQRIQDDMNRRDMSNLTSGQLALIILAFGACKTPDVRFIHDHHLVEKLGEKFKEEIKNMEIHNSNPLTNYYQLSFDVLTLCLFRGNYSISNVTHYFNPENKNFNLSGHFSVDTGAVAVLALTCVKRSISNGKIKAAIKDSDTIQKYIESLVHKIQSEKMVVSLETRIAQEKLCRLSLSHQTITKMNQIAKKLWTRCLTHSQGVFRLPIAAAQILPALLGKTYLDVTKLLLVPKVQVNITDEPVPVVPTLSPENISVIYCVKINEISNCINITVFLDVMKAAQEKNSTIYGFTMTETPWGPYITSVQGIWANNNERTYWEHSEQQQITKPRSMGIMLSKMESI
The following text describes a protein:
Function:
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
Subcellular Localization:
Chromosome. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
SAHQQGPARPGPAAMPRMLRTYSRRGGYLRALPQPDRWISPPQDRRRLFSSSSAASSALSSALSSAPSATSDDPDFSPPRKRRQKPLGERPARPRYLRSRRGAEKENRAPAALSSPSPSPVEGGSALQCSPELFSSHDASLGSAANSPGTPRGGSERLPLVPRASVREPPHGAAAVAPLDGEPRRSAVRGAAGSEGPRGDAKGDATAGSPGRHGGAAERRLMPVVVLDRGEVPLWLSGRKAASPPGRRGAAKYQRKSTKLIPGEGSTCRKACISGFSASRWGRQPRLRPHRHKNKRQQQAGSSFLRPPLRRRARRKGVQMSAGTQDAECSFLNNSHHWGRFRASLSFHKRKKVVSDDSSYASILCNPFVNSQLSGHQATLSSSKAESYALSASSVILLAPMSSSSVLEVTLTDAEKVFRECQQEGPITFEDCIPLDKMKDCKKIGEGVFGEVFQVDSERGPVALKIIPIEGTERVNGEAQKSFGEILPEIIISKELSLLSEESMNRTVGFISLYSVHCVQGAYPKYLLKAWDTYNKVTGSENDRPDLFGEEQLFMVLEFEFGGSDLENMRKKLSTVASAKSILHQVTASLAVAEQELHFEHRDLHWGNVLVKKTDAKELNYVLNGSTCTIPTAGIHVNIIDYTLSRLEKDGLTVFCDLSTDEELFQGTGDYQFDIYRQMKMENSNSWTDYHPHSNVLWLHYLSDKLLKDVVYKKKESSSAMRKIKQQLTKFHKEVLTFGSASEVLDRSSLFQ