lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Iridoid synthase that catalyzes the first step in generation of the iridoid ring scaffold using the linear monoterpene (6E)-8-oxogeranial as substrate. Reduces 8-oxogeranial, generating an unstable product that is subsequently cyclized into several possible products, either non-enzymically or by dedicated cyclases. Iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities.
Sequence:
MSWWYRRSIGETEQKRIEINGVSPTYQSVALIVGVTGIAGSGLAETLSFSDTPGGPWKVYGVARRPCPKWLAKLNVNYVQCDIANTDETYSKVAPLTDITHIFYVSWTGSEDVALNTLMFKNILDSVIPNAPNLKHVSLQTGIKYYWGNMAEMDSTNQPHECPFYENMPRLKQDNFYYNLEDLVYDSAVRKNGLSWSIHRPALIFGFSPCSMMNTVSTLCVYAAICKHENKPLVYTGTETSWTCLWDAVDSDLLAEHFLWAATVPNAKNQAFNINNGDVFKWKHMWKVLAKEFDIEAIGYEGKEPVLLEDLMKDKDSVWDEIVKKHDLVPTKLRDIAAFWLADVVFRNKETLCSMNKNKEFGFMGFRDTTKSFVSSINKMRDFKFIP
The following text describes a protein:
Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Sequence:
MSTKRVLCKFFMHGACLKGEYCEFSHDWNDQPNNVCTFYQKGSCSYGSRCRYDHVKVSRNPTVAPPPSSSTTTRASSSLQPLSFGRPHHVGYQADSSNPRQQISMDVLAHSGSKPVWRNDFQHESVLEDGIDWSISPTVQNQTTLSPADLPICSFAAGGNCPYGEECPQMHGDLCTTCGKMCLHPYRPDEREEHTKLCEKNHKRLESLKRSQEIECSVCLDRVLSKPTAAERKFGLLSECDHPFCISCIRNWRNNSPTSGMDVNSALRACPICRKLSYYVIPSVLWYFSKEEKLEIIDNYKAKLKSIDCKYFDFGTGTCPFGSSCFYKHAYRDGRLEEVILRHLDADDGSTVIAKNIRLSDFLSRLHL
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MALVVEQADRNKSFAEHEDLWSAILGEVLDASKTKLSGNKSVLVVGHDGSGKSTLISRMKNIEEKEKYHCSGLDYRYIDVDDEDSDEIYRFGVWILHGNAEHKSLLKFAINNDNLRDTAVVLVVDLSRPWEVMSCLTGWTKVLKEHMQSLNIDKNVIEEMKSNIVNQFQGYSEVADDADKSLKEEEKVYLPLGEDGATLAYTTLKEKKNVDILLRYLLHRLYGFSFKYPASVVEKDTIFIPSGWDTMKKIGILYEHMKYFSPDDAYEERIIKPPSTKAISESVQVVAEDDQIFLSKQQSILGVAKPSVASLLNRPPLGAAAVGGVSAATSTAITNAATAGNNSADTVGSTIAAKVASAASISPRAGGQSPRTNLSSAAPKVPLAIGSTAGATTNKTALSALMKKPGDTAKAGAAAGSSEGVLANFFSSLLNKKSGAGGSAGTTSANTPTPTSPPATTTSASRPTPPATSGSSTTSKASSSERASVLVKDLMAKRIAVRQNGNS
The following text describes a protein:
Function:
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. Is also able to catalyze the reverse reaction. Octanoyl-CoA can also act as a substrate although very poorly. Does not display lipoate protein ligase activity, despite its sequence similarity to LplA.
Miscellaneous:
MISCELLANEOUS: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. The reaction proceeds via an octanoyl-thioester enzyme intermediate.
Sequence:
MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGWNPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEMPATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELVVEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVAINELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNYKR
The following text describes a protein:
Function:
Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs and coordinating socket cell recruitment and differentiation at trichome sites.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MASSSSLTRSGSVHLDEKWKLSKKDGGASRITRSSSTSSSSFNGKKQGRCAFTRKCARLVKEQRARFYIMRRCVIMLICWRDNYSDS
The following text describes a protein:
Function:
Sodium-phosphate symporter. Active in early growth phase.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MALHQFDYIFAIAMLFAFLDAFNIGANDVANSFASSISSRSLKYWQAMVLAGLCEFLGAVLAGARVSGTIKNNIIDSSIFTNDPAVLMLTMTSALIGSSCWLTFATAIGMPVSTTHSIVGGTIGAGIAAGGANGVVWGWSGVSQIIASWFIAPILAGAIAAIVFSISRFSVLEVKSLERSIKNALLLVGVLVFATFSILTMLIVWKGSPNLHLDDLSETETAVSIVLTGAIASIVYFIFFYPFYRRKVLDQDWTLKLIDIFRGPSFYFKSTDDIPPMPEGHQLTIDYYEGRRNLGTTVSVEDEENKAASNSNDSVKNKEDIQEVDLVRTETEPETKLSTKQYWWSLLKQGPKKWPLLFWLVISHGWTQDVIHAQVNDRDMLSGDLKGMYERSKFYDNRVEYIYSVLQAITAATMSFAHGANDVANATGPLSAVYVIWKTNTIGAKSEVPVWVLAYGGVALVIGCWTYGYNIIKNLGNKMILQSPSRGFSIELAVAITTVMATQLGIPTSTTQIAVGGIVAVGLCNKDLKSVNWRMVAWCYSGWFLTLPIAGLIAGIINGIILNAPRFGVEYQMT
The following text describes a protein:
Function:
Binds the poly(A) tail of mRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MIATGTNMMHPSFSTASLYVGDLNEDVTEAVLYEIFNTVGHVSSIRVCRDSVTRKSLGYAYVNYHNLADAERALDTLNYTNIKGQPARLMWSHRDPSLRKSGTGNIFVKNLDKSIDNKALFDTFSMFGNILSCKVATDEFGKSKSYGFVHYEDEESAKEAIEKVNGVQLGSKNVYVGPFIKKSERATNDTKFTNLYVKNFPDSVTETHLRQLFNPYGEITSMIVKMDNKNRKFCFINYADAESAKNAMDNLNGKKITDDGQIDETYDPKKEEATASTSGAANQTTGTDADKTDKNDKNNKADKNEKGDSSNANNNATATGATTTDTTTTPGETTTTTANADSTGANNNNGLSPNTNTSNTTTGSSNNSINLNENNNTAGNNNSTNNNNNSGSSMNNAGSAKKDETAASDCADTPNILYVGPHQSRARRHAILKAKFDNLNVENKNKHQGVNLYIKNLDDGIDDIMLRELFEPFGTITSAKVMRDEKEQSKGFGFVCFASQEEANKAVTEMHLKIINGKPLYVGLAEKREQRLSRLQQRFRMHPIRHHMNNPLNTPMQYASPQSPQLQFSQNTLSYGRPVITAFNQNNLISWRHQQAAQQQAVHQQAVHQQAAQQQLNFNTNLRGQINQMRLYTQNNMMNNNLNQNKPNAQLHHNQQYVPNALAQNGQQQPNLNAAGQHNAQQLQQQGNNQLLNNNMRNMNNRANRNMGNLGNMNNQKQLPLNINNKQQNAASQANQMNHQAQPQGAQAQQKNPQQMQQVPQGNNFKFTAQARNRMELPNKNANKVNTMNNNMNVNFNNNSTLTAAALASAPPSMQKQVLGENLFPLVANYHPTLAGKITGMMLEMDNSELLILLENEEQLKKKIDEALVVLQKAK
The following text describes a protein:
Function:
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39.
Subcellular Localization:
Cytoplasm. Cell projection, cilium. Note=Localizes to cytoplasm and motile cilium.
Sequence:
MMDAEKVSTDGEAISEGEVGSNGETPPETEVEFIGETAPDTDVEFIGETSPGTDVEPTGESIQETEVESIGEATPGMDVEPIKKTMTELNVESIGEETSETDVDSIRKALRGIDLESITVAYPPKKAKHRKVRPQAEVESTGRAAPEGELEVSDHEKVEALLDELDELSEIVSSPEVSYSDISPLEMGEDDTNVSATSTDTFQQGIYEPIEPIEPTEPPEPAEPPKPAETPEDSTVRAPAHPYQRDFPMGARHRFRLSIMGSLTPSDTDDLPLETDEPPQQESVQSTPRALEETRIQFLDQVQSLSPEALLDRATEGSDEAEEEGSQLIVLDPDHPLMIRFQEALKGYLNRQMDKLKLDVQELDVATKQTRSQRQELGVNLYGVQQHLARLQMQLEKSHDRHSLVACERRRKEEELQCARSVYNKTCQTANEERKKLAALQTEVESLALHLFYMQNIEQDVRDDIQVMKQVVRKTETEKMHAEVEKKKQDLFVDQLTERSHQLEENIALFEAQYLSQAEDTRVLKKAVTEAITEIDTIAVEKKRILQQWTTSLVGMKHRNEAYKTVMDALRECQHQVKSTDSEIEVCKKSIMQEEEKNEKLARLLNRAETEATLVQKMTAQCLSKQEALQTEFNTYQLALQDTEEMLNKGYVEHSAVLSELQATRQAFHQEQELRQKMDMSMVDKLQEQGTSSKMTKYFHQLLRKLQKENTNLVTHLSKIDGDIAQATLDITNTNCKIDMHKKTLAEMDKEVKRFNDLITNSESEIARRTILIERKQSLINFFNKQLEQMVSELGGEEAGPLELEIKRLSKLTEEYNTGVAEAQMTWLRLQQELVQVTHEREEQLVSVDQLKKEVHIMEQKKLRIESKIAHEKKEQKIVSRHMRDLDNDLSKLNMLLDKNRCSSEELEQNNIATETEFLRTLKDSERETIQMQEKLMELSEEKATLLNSFMEAEHQIMLWEKKIQLAKEMRSSVDSETGQTEIRAMKAEIHRMKVRHGQLLKQQEKMIRDMELAVARRETIVVQAEGQSKIDKKVITKTEFHYQQRELQKKVREMHKATDDCTNTISELEETQKFLSSSLQEKQQLLSEMQATTDVLEEEINQLTALKRQNLLEIVTLQTRGKHLQAAIEGKYVFLHRNSRSQLMERKRLSVRLSQLNKVLSSVQEDYPQYQEVLQSIQQKIATKLETPEPS
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MTVTDEFKKQVSKTFGPKTDLSDDEYIKLQTLLDLFNKSMDDIFVEWESFNITEVKEDLDLNLSNLIRFQGYLQTKLAKNSTPVSKKTRDTIGSTSNRKQFRTVDNHHLTPQLKKRKFEDNTPEFKTPAGIPVSSPTTDYETANNTFVGLTTNGTPTTTTAKTTPSNSLLETLNPQIDEITIDQLPEGKTFRLSTNFDASKFKFRTMQMKLLESADVLDDQIDRMISLYQDQNKTADLQFGNPCMSTQSDILCCGRIVPDNPLYDKEILNSTSLFLETSRISGIGQRIPLDLSNLSNYSFFPGQIVVLKGKNPSGKSFIVEQNMPLPQLGAPVTSSEELKEFQTLQNNQGLKVLIASGPFSNSNKLNYDKLDKLVDLINTKILPQVVILNGPFLDIGNKVVESGEIIIDSDQSQPQPKTLDDLFKAIVTPVLKKIDSKIQVILYPNLRDTCIKHCSYPQDSFDRKKLGLPKNFKVFPNPSGFSINEVLIGNSNLDIFKDLRDIYKEDTAIISNNRFERIVKHIFEQRRYYPIFPGSIKTEPKQKCTELLNGAQGEYLDGIAVGGSSLETPYLGLSELGDSLPDVLILPSELKYFAKVIQGVIVINPGIFIKPSKDPNREEGSYAVVNIQPPNFDAEDNIEAIDDTNTLYYHNVNKRSRVDIYSS
The following text describes a protein:
Function:
Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MLRPIANRKNVTLMSDSLPLSVQPPAHVVLYQPEIPQNTGNIGRTCVAVGAKLWIVEPASFQFDEKRLRRAGLDYWQYLDWEPVPSWDALCERLNPERFFFFSKFAKRTVWEAEFALGDVLVFGRETSGLPASILKPDDPRSLRLPMREQVRSLNLSVTAGIALYEHQRQTIDLLPA
The following text describes a protein:
Function:
Binds to 23S rRNA.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MKKIEDNNTLVFIVDLKADKKIKAAVKKMYDIQAKKVNTLIRPDGKKKAYVKLLMHGRRL
The following text describes a protein:
Function:
Plays a role in the stress response to heavy metals such as copper, probably in a fos-1/kgb-1-dependent manner.
Sequence:
MSYYGNGGYNPYGAYGNVPPPVYGTPGLAPPTVHVHTDGGHHHGHHHHHHSFLHELGHALTGHHHHHHGHHFGHHHHHHHGHH
The following text describes a protein:
Function:
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly. Recruits NIN and CEP170 to centrosomes. Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Cell projection, neuron projection. Cell projection, growth cone. Endosome. Note=Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells. Recruited to subdistal appendages by ODF2. In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas. Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells.
Sequence:
MEVKGQLISSPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGAGPQLCKPEGLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEALLVDRAAGGGAGSPPAPLAPSASGPPVCKSSEVLYERPQPTPAFSSRTAGPPDPPRAARPSSAAPASRGAPRLPPVCGDFLLDYSLDRGLPRSGGGTGWGELPPAAEVPGPLSRRDGLLTMLPGPPPVYAADSNSPLLRTKDPHTRATRTKPCGLPPEAAEGPEVHPNPLLWMPPPTRIPSAGERSGHKNLALEGLRDWYIRNSGLAAGPQRRPVLPSVGPPHPPFLHARCYEVGQALYGAPSQAPLPHSRSFTAPPVSGRYGGCFY
The following text describes a protein:
Function:
Involved in the synthesis of fatty acids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MKVTVISGSSSEVVELPSNAGLTDLKKVYKPRVDIHRKSFKILRSGGDKNDKSAYITLDAKRALTEQGVKDGSEVVYKDLGPQVGYRTVFVVEYAGPLAIMLAYAARPSFIYGSSIVKEYCYTQKLYIALFCAHFIKRELETFFVHKFSHPTMPRRNIIKNCVYYWTFALGIGYALCSPYYTEPASPTLVNASAVAMVIFELLNFAVHVQLSGMRKGDGDATRPVPKGILFSLVSCPNYLFEILSWVAFSLGTSMLTSWGFTFAGLVQMAEWAVKKHKNYIKTDPSVRNKKAMLPFLL
The following text describes a protein:
Function:
As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Acts as a light chain for MYO7B and is required for efficient targeting of the IMAC to the tips of border brush microvilli.
Subcellular Localization:
[Isoform 1]: Cell projection, microvillus. Note=Enriched at the distal tips of enterocyte microvilli.
Sequence:
MAKFLSQDQINEYKECFSLYDKQQRGKIKATDLLVSMRCLGASPTPGEVQRHLQTHGIDKNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMKLGEKLTHKEVDDLFKEAGIEPNGQVKYDTFIQRITIPVRDY
The following text describes a protein:
Function:
Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation.
Subcellular Localization:
Cytoplasm.
Sequence:
KSSVAMEADVVQGQFDDADSADEAAERLRSLTCQARLGGAEQKTSKSSDDLDEEGTNDDDDDDMFDDWDDDECRSLQHPGGSHPNAQGSSLSKYQNQSKLLSGRYGSKINLEPYGGPRVPSGAANVLHEANRRQDSDRVRLRDKGERATAEQVLDRNTRIILFKLLNKGVVGQINGCVSTGKEANVYHATAADGTDRAIKVYKTSILVFKDRDRYVTGEFRFRNGYCSSNPRKMVRTWAEKEMRNLSRIYAVGLPCPKPVVLRSHVLVMNFVGKDGWPAPKLKDVPMSASKSRELYLDCVVMMRRLFHDCRLVHADLSEYNLLYHEGKVVLIDVSQSVEHDHPNALEFLRKDCTNITDFFGRKDVRTMSVRQLFDFVTDPTVNEGNMDAYLERASEEAGLRESGGMDVVEEEVFKRAFIPQRLDQVVDFEKDVARVQGHKEEVLYHTVTGMKSDLSGPAEKPSLLEGSESSEGSQDEGSSCEEADDDETDEKTSKFANAARPKGETADERKERKKAVKDAKKEKRQTKLPKHVKKRKEKQGKARKK
The following text describes a protein:
Function:
Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
Subcellular Localization:
Cell projection, dendrite. Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MEENKAKHSDLSLAGVQRLQEEQAKEAEDCQQNIQQCKKLISDYEDLQSTLETLPYKRSYDIMVPFCGELAFFPGNLVHTNEVTALIGDNWFADVSAKEAQDIANRRKLELNETLSKLEQQRQNLSERLKLNSEFERDLVEKDGDGVIEIKEELTEKDEDLLYPVKRISRLKSNENTKSNISTANEKTKVNTSTSSIETDDAYWDRLEKLEAENEELSDEFTSQYDVQDDTTIRFHHSQKTPKENVPSLAQEISSHSSIERPDQVQKLISQGSHTANESKIVNTATKSFTGEIVEKQSPTTKPAPVTAKTIEKSSTPVSSEVDLKFTAISDGSISFACFKD
The following text describes a protein:
Function:
Binds to SIN3.
Miscellaneous:
MISCELLANEOUS: Present with 211 molecules/cell in log phase SD medium.
Sequence:
MQLEATHQKENHLSPLASFIFPDFRALFNIGFNLYSNINYKEVDINGFEIYIVEQWAAQRKISTLITSYTGNLQDTISAVEVALPEDPEEWPCCLKKYHEELLKFSSPKKTAKGTLFVTNLSSFKSTLNLLHVECGNLKKIWKNFKTNYDLKRLHCGGRSAQLLKKTPSASIAKFAQLYKFPNSAFSHEITSDFQQPSLQNDNSSISSIENIPVNHCPVVELTTLVQISLSYFALFEYKKERDGLLCNGTKQSLEKWWEIYGKRYHGIDKPKNETILGPTTVASLLSLVLTCYFKLMVEDCMSAKDPFDEEEFYSGLYAFQKKYGLSKNNKQTSLDELTIDKLFEVSSKTSNKDIFKFKKVVKSTVQDMTGKGNFMHLSNEILTTDLDTLVKNIHGGSLGKLWKGRSASRKETCMVWERKTFLSFKFERGDPSLQLENNELFYGTSVPSEQLTTSNKEDSDTQPTKRNSIYDIANGSKSSLSISSMFCNYDETRYKSTNNLNRAYRGEYFRRNSIPFCNDGIHDTKKISADLNKIDGLYRCNSYSEVQNAIELWSLPFDSSVIRLARDLLKIQSLMSVQRQLDEIRDGYLGKNSQRSYQNDLMFRQSLNKLQEMCERCKRGSNEFHWEYGNMQNKQQILESEKKDMKSLSSKLKYNVRILDRRVRDVEASVDHFDRKLEDVRKKLLEQNNSKDISMALESPCDKFEFDSFMDSIVQSQQTKYEGLCFKILDKKSLRKLKKEFWKWSTWTFDTFLYKNRPNKEKDTL
The following text describes a protein:
Function:
Sodium-phosphate symporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSHYYAGDSTVIWIVVISFIVAFVLAMGLGANDVANSFGTSVGAGVLTLYQACVVAAIFETAGAILLGYRVSDTIRKGIFDPLLYNGRDELLLIGNLCALSASGIWLFTATILSVPVSATHSIVGATLGFHMVVYGGVGVNWNTVVAIVISWFVSPVLSGFISSCIYGLLYFSVIKRDDPLKWGIYTVPMWYFFLIFINFFSIFYGSSVLFGFDELWIVMVISIGGGLVVAGFGFFFIIPWIKKRVYKLKKQEKLEKAEEGHTQIDQEQETELKGLPNAHNAGDAASLEKKNPDDPDAILVPEPPMTNGIGNGMTSGMTNGMSTGMSNGMGNGAVPDYDRAIMVEMTVNDEGEGNSDKWLVKKGSKEWDSVKDTTEVRAICSPLQVVSACFAAFSHGGNDVSNAIGPLISIWTIFTTGSVDQETLTPIWILLYGGVGISLGLFLFGRRVIKTIGEDLTPMTPSSGFCVELGSASTVLLASNLGIPISTTHCQVGSVCGVGWLRTRKAVDWPLFSGIFFAWVVTLPATMMLSSGLMGFLQHVVPGGCELVPIPLDNSTAMATTLGLV
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEYGITPAGGFRWRSYRDLIRDVFIAGDMYCGPAKLLFPQITGSAGEDQARCGWSSASSVASSPVVSSSYMSSSGSPAWSSASSSPVHKLRVIAQQMVGDGYIQELIRAFGRRRPDELIFQRWFSQLDVDFVLVLHTDGMVRADSFSVEDLMALIKRWIRALLTMVQVLNITLLELPLPVAGSTERMAAAADHAQFTGFAEESILRMLAFVDAVTLSALNVNDDHRHRTPELLPGMLQLYACVSEACDLLVSAGMGKDEITKMQALDAMNNGILMQSRRKLSDAIWVMMEKVRALFLMDACWQVSQEAAASGTHETTELTMNYITLLWRNHTMLDYFSVFVSDADSFSSVARLIAEMITCLECKLEETSLSIPDLGLRFIFLLNNWHRVLQRVESLRDLPAAVRQERILLLHASDSKIKRYIDDYLNASWSPLLRCLLIDKPFVALGRSHESKIETQLQTTYATQKFWKVPNPQLRQRLRRAIMSKVIPDYSKYIEQMDRQNKINRHLVVTSPEQLEQQIEELFEG
The following text describes a protein:
Function:
Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MALAVFFGCTFVAFGPALSLFILTIAADPLKVIILVAGSFFWLVSVLLSSLIWFISVQISNKNDANLQYGLLIFGAAVSVLLQETFRYAYYRLLKKADEGLATISEDGRSPISIQQMAYVSGFSFGIISGVFSVINILADAIGPGTVGVHGDSQYYFLTSAFLTMAIVFLHTFWGIVFFAACEKRRPLHIVGVVLSHLVTSGLTFLNPMYEASLIPIYIITLGMALWAFVAAGGNYRNIRKCLACAR
The following text describes a protein:
Function:
DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6A.
Miscellaneous:
MISCELLANEOUS: Present with 4590 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAATKEAKQPKEPKKRTTRRKKDPNAPKRGLSAYMFFANENRDIVRSENPDVTFGQVGRILGERWKALTAEEKQPYESKAQADKKRYESEKELYNATRA
The following text describes a protein:
Function:
Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes like catalase ctt1 and components of the cellular thiol-reducing pathways, including the thioredoxin system (trx2, trr1), ABC transporters involved in multidrug resistance like bfr1/hba2 and pmd1 as well as the gene obr1/apt1. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress induces nuclear accumulation and as a result pap1 transcriptional activity. Required for sty1/spc1-conferred staurosporine resistance.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Oxidized pap1 is found predominantly in the nucleus, while reduced pap1 is continuously exported to the cytoplasm by crm1/exportin 1.
Domain:
Contains two cysteine rich domains (CRD), referred to as the N- and C-terminal CRD's, n-CRD (Cys-259, Cys-278, Cys-285 and Cys-290) and c-CRD (Cys-501, Cys-523 and Cys-532), respectively. Cys-259 and Cys-290 are not conserved in orthologs in other yeast species. A nuclear export signal is embedded in the c-CRD, with which the nuclear export protein crm1/exportin 1 interacts only in the absence of disulfide bonds (or otherwise oxidized cysteines) within the c-CRD or between the c-CRD and the n-CRD.
Sequence:
MSGQTETLSSTSNIPIAKAEPEQSADFSASHKKRGPVSDRSSRRTSSEEVDLMPNVDDEVDGDVKPKKIGRKNSDQEPSSKRKAQNRAAQRAFRKRKEDHLKALETQVVTLKELHSSTTLENDQLRQKVRQLEEELRILKDGSFTFEMSLPHRNPSLSSLPTTGFSSNFAHMKDGISPQSNLHLSPNSIEKPNMHQNVLHNDRSADNLNHRYQVPPTLVDSNSAQGTLSPETPSSSDSPSNLYLNYPKRKSITHLHHDCSALSNGENGEDVADGKQFCQKLSTACGSIACSMLTKTTPHRASVDILSNLHESTVSPPMADESVQRSSEVSKSIPNVELSLNVNQQFVSPFGGTDSFPLPTDTGLDSLFEPDSAIENSHLKNVVMEPELFQAWREPAESLDKEFFNDEGEIDDVFHNYFHNSNENGDLITNSLHGLDFLENANESFPEQMYPFIKHNKDYISNHPDEVPPDGLPQKGKHDTSSQMPSENEIVPAKERAYLSCPKVWSKIINHPRFESFDIDDLCSKLKNKAKCSSSGVLLDERDVEAALNQFN
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.
Sequence:
MRKFAYCKVVLATSLVWVLLDMFLLLYFSECNKCDEKKERGLPPGDVPELVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYSDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHILEEIILVDDASERDFLKRLLENYVKKLQIPVHVIRMEQRSGLIRARLKGAAASKGQVITFLDAHCECTVGWLEPLLARIKADRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRLGLRHKLQCKPFSWYLENVYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVVSLFMTGIQDVKRFCEHNCVLIWVCELGSCWLEMGDRIIAILCNKEPRFVLCSN
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of short and medium chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain.
Sequence:
MLTYRPDRVQRKAGPRLIEEDDRLSLPLSYLPLQRKEYDLENRKKLSFAVSQPLSSTRKMHCIRSSILQHLRLRVPVRSVLLLEKENVLISKMNFTSGGGQDQVLSKVIELVKKYDTTSASKVTETADFKKDLSLDSLDRVEIVMAIEEEFSVEIPDEKADKLTCCADIASFIVSETQSKAPESCLYFLSSLFC
The following text describes a protein:
Function:
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular Localization:
Peroxisome membrane; Single-pass membrane protein.
Sequence:
MAAQQDGSGGGGSSENLVFQAPQVAREDYIQNAVKFLEHPKVKGSPVSYRYSFLEKKGLTKEEIDEAFRRVPDPPTNSTDAAAVGSQQASNPNQSARVQPYAPVQSPQAPTGSVATGHIIPQTQTQFSWYHTLLGAGIFLGVGASSVLIIKKLFLPRLKSWTRRVVSEGDENADNELKSKLYDEIKDAMEASSSAFSAIAKTNQELLASKDEDKKILVKLTEALDSQAEVLKSLSETLHHTRENRFSPYNMLEEHAQPGPWNGPTTNSWRASQQTNMYTTTPNGDFDSGRQSFMPLPAEPTSGSFPRSYVDPRVPRSGYGFQPQMGYDRSNPGTREGYYGSPPYYPGGSNTVDAPAPAPAPVAAPAPAPAATPVAQESPFQRHWVPPQPPGVAMPEAAAAIRQPRSLPRQEPQPAADSADATRLADSAMNEQMDGVSSAVTSDESRSSSAAMGTMAGAANGENGEGPGAA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MIHPKLVAPVQWESRFKKKKFRSSTRRHCHGGVLKKTTGLVGLAVCNTPHERLRILYTKILDVLEEIPKNAAYRKYTEEITNEKLAMVKAEPEVKKLEDQLQGSQLEEVIL