lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MSNDIQGFILHFLNEEPFNLNLSSLQFDQLPPQQLLQILSNVLSWVSDTDRIDIKREAAEETAIRILNMLRILRYRPPQDQDEQEEWRAGIVEGRKTSLYPLLVFLFENSEGLKERAYLSKYLMKTDVPGEFFDYDIEELQNEIGELTMEFKEIHAEMKGIMADVLLLDDIKEDLKSMEKEKQILLRKIEKTEKKVQNIPYFDKQMQLALQLRGEKTRYADFAIEKQQERQKVLNIEARINRMKINLTEAQAVADTLDEQALMEKLEDEVATNTYLVNGKLFQEIESKENKLKELTAMARSNSVREEDVSRMNSEIEEMSKRIRKLEDERDHKEVDIDENMSVFRHQTSLLERKKETAVQKLQELRQELAKIEKDVDERKTNLKDKVGGEVVSNVQYRKYLEQYRVKSEEQKKKRKEIELMHTEVAVLKRTIDIVSKRYNKLETHIESIGGEIVEVLNVPTKYDRPKTAAPQTNNAEDIKSDMKDMMAALDERKDKITDQRTKRDEVKYVVQQKMSQLATIKMEADQFMAELERDNKRLVENVKELETTVRDCDDRIPELKNELAILLDDKNKMEGVSGENLEELLSKAAEKEQRIDTEIEEMGDFDESRMQAELWKGLLTIFETKIEIFKERANSRN
The following text describes a protein:
Function:
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Sequence:
MTSYRPEFSASEQSQIDAEFSRLASNKSVYLDHAGTTLYAESQVTAAAEQLQRNVICNPHTCRLTGDFVDQVRFKILEFFNTTAEDYHVIFTANATAALSLVAENFDFGSSGEFHFCQENHTSVLGMRERVRENGIYMLRENEISGGKHKANGKVHEVSGKTGNSLLTFSAQCNFSGYKIPLEVIEQIQIDGLAKPGKELWSSLGEKKKNMHNDYYICLDAASFVATSPLDLQKYRPDYVCLSFYKIFGYPTGVGALLVSRRGAEVFQKRRFFGGGTINYAYPHAMDYQLRETFHQRYEDGTLPFLSIVGLLEGFRTLERLVPRTDEFSTMERISRHVFGLAKYLEDQLRQLHHPNGEPLVKLYNKVGYQDKSRQGGIVAFNVRTESGSFVGFGEIACVAALHGILLRTGCFCNIGACQYYLGLDEDALDAIYKRAGRICGDYFDLIDGQPTGAVRVSFGYMTTIQDVDKLLQMLRSSYLATKPLQRIQFIEEQAEQLPPLLKERVQLLRPKLLQMAIYPVKSCAAFKIELPGSWPLTDQGLKYDREWMIVDMNGMALTQKRCTELCLIRPVIKVDQLELQFGENSTISVPLSLDDQAADTAKCVSKVCRQPVEGLDCGDRVAQWLSENLGMEGLRLLRQSGQRNSSKDQQKLSLVNQAQFLLLNKSSVRSLQFEEPLDETVDRFRANIIIDTGSAFEELTYKALSIGGIQFQVEGPCQRCDMICINQRTGERSPETLTTISRLQKGRMRFGIYITRIPQDTKELEPKEQHMTCGDVVLVE
The following text describes a protein:
Function:
Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MVSVIEAHNTQWSELHRAQHPNILSLSQYLILPIDVRKREKSSARHNSSERGRQLSIAMQPLTRLIPRFAIDSGSASISRSLRISPRPSLKSSICLQCRIYSPSLRRHFADDQRPIIEPPPHLRPKVTPPEDPKPQPQPEEEKPASIPEYSKQDDSPSPQLERDRELPSTLESRRLAMTKKLSHLMDHMQGNIFIASQRINDLTGYSGIEALKNKITNLEAQVASSKELVRSTRLHYKTTVADRASSQREVTTLLARKDTWTPADLERFTHLYRMDHTNEQAVQEAATRLADAEREAEKAAGELSSSILSRYHEEQIWSDKIRRMSTWGTWGLMGVNVLLFLVFQFGFEPWRRRRLVAGFEEKVREALEQEKTLAMSTAIRGAEIGGGEGSEVSLDEIVAAEVQELKEEALVEGLGEPAVEAVAATIEGEVPHHESNNEPAQEIGEAAAAMDTAELNIPYSRPPPFDYRNIESWKEKMEAGKAAAIDLWSTRQVSITKKDITIIALEGAAGGAVLAGAIFTFIIRRS
The following text describes a protein:
Function:
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MSSSLFLCSSQVRYASLPAPLRQPGRHAARLPPAAAAFVSLPRHRAPPLHWTGSGVRMISSCFVVKRRRRRNGIYASLFGVGAPEALVIGVVALLVFGPKGLAEAARSLGKTLRAFQPTIRELQDVSRDFKNTLEREIGLDEDPPSMSYRPPPPMNNSQQPAVDQDVKPETTVPYTSEELMKVTEEQLAASAIAAWNAQQPPSSEQQEAAAATTPSESTDSALSVGSDGPGAVPEESTSGNAENAKPRDEA
The following text describes a protein:
Function:
NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.
Sequence:
MTSASLENGVSRLNIYRTTSNTSSQVSLKHDYIDSPFSGKKDQFDQVLDVLDSTGFIPESLIESEAKWFYESLGIDDVFFARSSPEDIASHIHALYSCKVQAYSSFGEQPLISYKREAEDHAVFFDTVDAESYKRNQFEERIDDKYIDPSSTTTNSYRTEYFSAPLNYQSDPILSGVYQQNKELRDQYVRLFFVYKNNYTISEAAANETDLEKIGDKTFLKIASDNTKQLYTSIVKDVINTTGPVIKHFPLEDSEEYRVVIGYKQKTSARYNSALSDLANYYKLQVTRKYVEQFSNGVTIISMYVTSKSRKSPVDLSIYQVIKEASLLYCIPHNYFHDRFIQGELSLQESIYAQSGVIFVTHFLNRLGPEYNKLSSLLDPSKSIEHAEVLNSLKKRLRAETYTQDYIKEVFDNRRDIVRKLYRQFADVHYIRSSMEKTLSYQRLSQITPVGSEEEFEQLLSRECSQNEHHAIVLRALYTFNKSILKTNFYTSTKVALSFRLNPSFLPESEYPERPYGMFFVVGSDFRGFHIRFRDIARGGIRIVRSRSLDAYNVNARNLFDENYNLANTQQRKNKDIPEGGSKGVILLDPGAAQERPQACFEKYIDALIDLLLKQNIPGVKDNYVDLYAKPEILFLGPDEGTAGYVDWATLHARERGAPWWKSFLTGKSPELGGIPHDEYGMTTLSVRAYVNKIYEKLDIDDAKIRKFQTGGPDGDLGSNEILLSRKENYVGIVDGSGVICDPQGLDKQELIRLAKERKMIEHYDKTKLSPQGYVVLVDDMDVKLPSGEVVTSGVAFRNTFHLKLKQQFGVDGVDLFVPCGGRPAAIDTNNVHDLIDEKTGKSVVPYFVEGANLFITQSAKLILEKAGIVIFKDASTNKGGVTSSSLEVLASLSFDDKGFLENMCVDPETKAKPQFYQDYVKDVQKIIVGNADSEFEALWKLKAETGTPFTILSDKLSVAINKLGDELANSKELWNDDIEFRNAVLLDSLPPLLLEKVGIENVLSRVPEAYLKAIFATHLASKFVYSRGIDSNPAKFLEFISSIRKDFIQKGLLKY
The following text describes a protein:
Function:
Involved in the degradation of 2,4-dinitroanisole (DNAN), an insensitive munition ingredient used in explosive formulations as a replacement for 2,4,6-trinitrotoluene (TNT). Catalyzes the removal of the methyl group from 2,4-dinitroanisole (DNAN) to yield 2,4-dinitrophenol (2,4-DNP) and methanol.
Miscellaneous:
MISCELLANEOUS: Unlike other known O-demethylases, it does not require oxygen or electron donors.
Sequence:
MTGRQRTTVVAPDRPVQDATISQLTTRVWTVAIDGYRTIVVEGETGIVAINSFGTPSAQTKYRELITQTFGDKPVVAVVASIDHLDHTGRLGPFANGAEVIGHELGQAIAFGRGLPEQKLADTVVTGPVTEIERAGVRLVLRYPAPTVGTGNLAVDLPDDDVVFMVGLQSGARYGIFPDFHFKHFLRATSEIAALGRRYFVPGRSEVMDAGQVRQALEYVNDFQNACQRCLAGGEVPHWLLEPTTAYLHDELSSKWSHLEGYDPVAVGLGGLRVVCHYYMGGWWLDDTDHHELLYDHLTVRTYREYRERLATAGTGRA
The following text describes a protein:
Function:
As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Presynaptic cell membrane; Single-pass membrane protein. Synapse. Cell projection, axon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Postsynaptic density membrane. Cell projection, dendritic spine.
Sequence:
MAASSSQVSEMKGVEDSSKTQTEGPRHSEEGLGPVQVVAEIPDQPEALQPGPGITAAPVDSGPKAELAPETTETPVETPETVQATDLSLNPEEGSKASPSPSPSEARQEPASKPDVNRETAAEEGSEPQSTAPPEPTSEPAFQINTQSDPQPTSQPPPKPPLQAEPPTQEDPTTEVLTESTGEKQENGAVVPLQAGDGEEGPAPQPHSPPSTKTPPANGAPPRVLQKLVEEDRIGRAHGGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK
The following text describes a protein:
Function:
Involved in defense response to geminivirus infection.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MEGVRFVVWRLGFLVFVWFFDISSATLSPTGVNYEVTALVAVKNELNDPYKVLENWDVNSVDPCSWRMVSCTDGYVSSLDLPSQSLSGTLSPRIGNLTYLQSVVLQNNAITGPIPETIGRLEKLQSLDLSNNSFTGEIPASLGELKNLNYLRLNNNSLIGTCPESLSKIEGLTLVDISYNNLSGSLPKVSARTFKVIGNALICGPKAVSNCSAVPEPLTLPQDGPDESGTRTNGHHVALAFAASFSAAFFVFFTSGMFLWWRYRRNKQIFFDVNEQYDPEVSLGHLKRYTFKELRSATNHFNSKNILGRGGYGIVYKGHLNDGTLVAVKRLKDCNIAGGEVQFQTEVETISLALHRNLLRLRGFCSSNQERILVYPYMPNGSVASRLKDNIRGEPALDWSRRKKIAVGTARGLVYLHEQCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLLDHRDSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQKALDFGRSAHQKGVMLDWVKKLHQEGKLKQLIDKDLNDKFDRVELEEIVQVALLCTQFNPSHRPKMSEVMKMLEGDGLAERWEATQNGTGEHQPPPLPPGMVSSSPRVRYYSDYIQESSLVVEAIELSGPR
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MSLLSAHLEQISISCQGIDSLPFPPPKIFTNALLSNPDITSLIRDTEAHERALFSVPPPPPRQTTLTAEQQQQQKPSNRRQTVFNVTGGEIRTGGVGSASTARRNTAVAAVLGGDLHAQIMRGTRARPGQQPGSGDIDMEVLLRGVEKLCAVYPLPGALERVPVIRQKWQAQSNTLAYYEAKIAEQQEMLDRIAQERMMNDGDGDVEMEDVEEVGMTEEDLRREEEEVRELDKRKRDLQARLRALDADLGGLLNV
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MNIPFNSVSKIQWRNPSPVSDTSCLVCGDPHGKRHYGAMSCNGCKGFFRRSIWEKRTYKCSFNNECIIEFKYRNRCRACRLKRCLHVGMDANAVRSERTRKIKTEIDGDVKLEIKEEPADSEDADDECPLDIKPDIAMAWQTKEIIAHMLYEEDRVLNWEEPYNKLRYYTMDSEVLQAIKDPSQVCARTKINWNSHSRPLITIEALRFNWCRTFTLTIDWFETLPEYRALIDDDKELLVKFSLMPVGWLWYAYKSYEYRCDGIVFVDGSWFPRDKTIQQQVCPTCVLYYGRITESFMADVVNSMKELEMDETEMVLLKAICHLQPDYRLTRRGNDVISTGREKYKRALCEYIRMKSNGFMDASFRLCKLMQILPVVDILGKYEDESALLVSLGETEFNGSGGGLPYDIHASDSHFARKNRRKSDNQYHQQHVPLHIQ
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
METLDEPLYVNAKQYHRIIKRRQARAKLEAEGKIPKVRKKYLHESRHQHACRRKRSNGGRFVTKPGEESDESQDASEKQIEVQPQHTGSMTHGQEGQLPSEQTTEGVE
The following text describes a protein:
Function:
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity; [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding; [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
Subcellular Localization:
Secreted. Golgi apparatus, trans-Golgi network.
Domain:
ProSAAS(1-180) increases secretion of enzymatically inactive PCSK1; The C-terminal inhibitory domain is involved in inhibition of PCSK1. It corresponds to the probable processing intermediate Big PEN-LEN, binds to PCSK1 in vitro and contains the hexapeptide L-L-R-V-K-R, which, as a synthetic peptide, is sufficient for PCSK1 inhibition; [Big LEN]: The four C-terminal amino acids of Big LEN are sufficient to bind and activate GPR171.
Sequence:
MAGSPLLCGPRAGGVGILVLLLLGLLRLPPTLSARPVKEPRSLSAASAPLVETSTPLRLRRAVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRAWGSPRASDPPLAPDDDPDAPAAQLARALLRARLDPAALAAQLVPAPAAAPRPRPPVYDDGPTGPDVEDAGDETPDVDPELLRYLLGRILTGSSEPEAAPAPRRLRRSVDQDLGPEVPPENVLGALLRVKRLENPSPQAPARRLLPP
The following text describes a protein:
Function:
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAETAIAFRCQDYVMVAAAGLNAFYYIKITDAEDKITQLDTHQLVACTGENGPRVNFTEYVKRNLMLNRMRQHGRHSSCDSTANFMRNCLASAIRSREGAYQVSCLFAGYDMPVSEDDNGAVGPQLFYLDYLGTLQAVPYGCHGYGACFVTALLDCLWRPDLTQQEGLELMQKCCDEVKRRVVISNSHFFVKAVTKNGVEVITAVH
The following text describes a protein:
Function:
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MGLLSVDLLVTLQILPGFFSNCLFFVLYDSIVLVKRVVSLLSCSGSTGEWQRMLTTAGVRSIWNSFLLDAYKQVKLGEAAPNSKVVKVTGINRCWSISGKTHNQCHLLDFESPDRPLVVNFGSATUPPFISQLPVFRRMVEEFSDVADFLLVYIDEAHPSDGWVGPPMENFSFEVRKHRNLEERMFAARTLLEHFSLPPQCQLVADCMDNNANIAYGVSYERVCIVQKNKIAYLGGKGPFFYNLKDVRRWLEKCYGK
The following text describes a protein:
Function:
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein. Acts together with NFU1, later than BOL1 and GRX5 in the [4Fe-4S] cluster insertion process. Not required for [2Fe-2S] cluster insertion into mitochondrial proteins.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MKLPQTMLRSISVKHVRWPRILTGSKLWYSTQMAMTPEEKMITDKLQQELEPEVCKVQDVSGGCGSMFAINITSKKFNGLSLIKQHQLVNRILRDDISRWHGLQLTTKKSTGKGPASS
The following text describes a protein:
Function:
DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.
Miscellaneous:
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSSSENTLLDGKSENTIRFLTFNVNGIRTFFHYQPFSQMNQSLRSVFDFFRADIITFQELKTEKLSISKWGRVDGFYSFISIPQTRKGYSGVGCWIRIPEKNHPLYHALQVVKAEEGITGYLTIKNGKHSAISYRNDVNQGIGGYDSLDPDLDEKSALELDSEGRCVMVELACGIVIISVYCPANSNSSEEGEMFRLRFLKVLLRRVRNLDKIGKKIVLMGDVNVCRDLIDSADTLEQFSIPITDPMGGTKLEAQYRDKAIQFIINPDTPHRRIFNQILADSLLPDASKRGILIDTTRLIQTRNRLKMYTVWNMLKNLRPSNYGSRIDFILVSLKLERCIKAADILPDILGSDHCPVYSDLDILDDRIEPGTTQVPIPKFEARYKYNLRNHNVLEMFAKKDTNKESNKQKYCVSKVMNTKKNSNIKNKSLDSFFQKVNGEKDDRIKESSEIPQQAKKRISTPKLNFKDVFGKPPLCRHGEESMLKTSKTSANPGRKFWICKRSRGDSNNTESSCGFFQWV
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
Subcellular Localization:
Cytoplasm.
Sequence:
MIQVMIVEDDPMVREINSKFLKRVEGFVLYKAVSNLYDAKKFIAMKKPDLILLDVYLPKENGIDLLKWIRKQDIDIDIILITADKSIERIQEAFRSGVVDYLIKPFNFERFKESLIQFKGRYYEFKKNNVIEQKDLDKIICSSNISQNEDDFAKGLNKYTYKSIWNEIEKSNDKDFTAEYLAEKLGIARVTVRRYLEYMEKENKVYKLVEYGKVGRPQHKYHKI
The following text describes a protein:
Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.
Subcellular Localization:
Cytoplasm. Cytoplasmic granule.
Sequence:
MGNILYCCRKVSEYITTKGAADQTEEHSALLSQENSDGESVSPSRTSADLLDSPVLDQDHLLFPDIVLSSNLHIRGDSTEALELLLATSGQEASREDGFDESNPRNGGERNRGLVGPPSTNITGTNQSRSIEDEWPLLSSLYQAPAAQNRICTHGLEADTCKPVFAHGTDVSSMFAASSLDVSKCDFDISQREDGTTQTEQYNELKTPKEQLHAEKKQDKKKLNESGPNSAAQAHLDAIKMQPAYGIPTEWPLLQKSQREAQTSELTAQPDEKLDFKIDAQASEILEMRIIKHEHATEKETSLVEQPDIADMSSGLEEQEFGEMKQSPSQIDQGFVWNKEVEQTQWDLEVLKQSSGLSLQHSEQTTLAVTQVERKEDQTERFTLFVVDKLFLATPNFTASSPDTMTSGNVLDGPAEGTAEQVSAVPDIDPCEDAGFTVKIQAPGTEPRDFQVSPLATVQEIKQVLMDQEETSRRTCFSLQLNGVTLDNFTHLRSIPDLQEGSVLSVVEEPYSVREVRMHLSHIRELLKSLDLTDGYNGVEGSSPSFLSCVTEEIMEESSKPKRRGDGMKQINCCPPDHLLPGCKERLLVPLQPHSAFGKSSECLKVLASSSWNPPPGNRKMHGDLMYLNVVTMEDRHFSITASTRGFFINQSTTYSFNPKPADPSFLSHALLDLLTQISPVFKKNFSALLKKRGSTHPFERIATPFQVFSWTAPALDHTLDCVRAEDVSSFRLGYEEHLPVQARDWNEELQTTRELPRKNVTDRLIRDRAIFKVNSDFVSAATRGAMAVVDGNVMPINPSEEPRQQMFVWNNIFFSLGFDVRDQYRELGGDSAAHAAPVLDLNGVKAYWVMDQEDLYLIGTAVIDYRGYRVTAKTIMPGILERDQEQSVVYGSTDFGKTVVSDDRYLELLDKPSKKLRVQRHRVLNKDDTTVELCSSVEHKGIVGNDGRHYILDLLFTFPPDLNFLHVEGEHLNPVCQQLGFPRLHPHRLVCLRQELLDAFVEHRYQMFMKTVSQSSDDDRRISQSDGTSVIKSDLSTAPQLPLNTVRIPEQKPKQPHQITNIQQSSSIKQIFSSLRNTFDLQFNPNVFCPGVRFPKESTEEIQKQKQQLKDAASFLISYQIPAFMKNCLEHTSMPTDGVTLTEALHQHGINIRYLGTVLEYIEEIPLKERLDHVYRIALCELITRCAKHLFKTYLLAVEPSALSASVSHFLNCFLSSFADAGVIQQSDRLASRRRSRRRRSQVSEGGTVTIWSTLTPSDLWRAISTEALEYYHYCLCCVSVEEAVDKCRLQRITLLRETAIKTGIQILLREYQFDSGQNVVFTEEDILNIFPVVKHISPRASDALYLLHRGQMKVQQGCLKEGCELICQALALFTNVYGALHQDVCVCLRLLGRIHYILGEYAEALSHQQRAVLISERVLGIEHPSTIQEYRLLGLYCFAGGQTVTALRLLYRARYLMLLVCGEDHPEMALLDSKIGLVLHSMMACELALKFLENALLLTSKYQGPSSLKLAQSHHLLAKVYESKGDFRVALKHEKERYGIYKKQVGEAHEKTQESSEYLKHLTHQAVILQKTMNWIYKTGSDTNISPLNLNSPSRVWIVEQLNLVTGIVLIPLSNSDLEKLRTGAQKTSQLTQNQDQSTEDLPEDHNISQAIIQED
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
HSPSPCRLILAPPVQAGAACNEPSTSCLVLSTLGAYSELTKHLFSIIENPSLSSKTIVDASAGKMWNVNDITGLLSALQEVDQLFNSRLEIAHQHAINQRRIEALQEQAKRRDRETRQAILELSRIQSELAEMARLSEEEVASIEKAEKQPIGHSTLLGYAQRLARYTSAPPGYKLPRVASAAATQKDDVAGVKSEQRADGEPVEQISLGADYNQYAKRAAAYYDPAIPSMPQEMPFPSDAMMRQGILNSQQMLDGAAPAEQPADETMDDSEELPLTDFAASYSHLRQQQQRHDEEDEDAFDLDLN
The following text describes a protein:
Function:
Member of the two-component regulatory system PfeR/PfeS. May activate PfeR by phosphorylation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRRHPLLWKLALLQVGFCLLLTWLIYTWGLSVERSTYFLAPADRHYLADYARQAEDAWRREGAAGAERFRKELSAKEDTWVALVGPHLESLGSTPLSAEESSHLTFMRKLDWPMSRRLQDELPYVSIEFPGHPEQGRLVIQLPERLLPGGLTPWTHLVTHGIVPTLLAALLGLLLYRHLVVPLNRLRDRADALRADELESTPLAAPLAARRDELGELAQALEHMAERLRLSLAQQRLLLRTLSHELRTPLARLRIAHDSELPPEQLRQRLDREIGDMQRLLEDTLDLAWMDTERPQLPTEPVLALSVWEALRDDACFESGWDPARLPCRLGVDCRVEVHLDSLAQAMENLLRNAIRHSPEDGTVSLDGEREGDFWHLRLQDQGPGVAEDQLERIFLPYQRLDDSAGEGFGLGLAIARRAIELQGGRLWASNGKPGLCLHLWLPAAA
The following text describes a protein:
Function:
Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on growth and on alkaline phosphatases production in the presence of sodium, by affecting the transcription of the phoP/phoR two-component regulatory system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVMLSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALSFIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGACFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAASTDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFVPYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIGLISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQRKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGFVKK
The following text describes a protein:
Function:
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
Subcellular Localization:
Cell projection, dendritic spine. Cytoplasm. Postsynaptic density.
Sequence:
MQLSRAAAAAAAAPAEPSAPLSPAPAPAPAPPGPLPRSAADGAPAGGQGGPGRRAEPPCAPLPAASGPGPGAGMDGPGSSAVVVRVGIPDLQQTKCLRLDPGAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLREYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLENATDLLKVLRNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHARLGTTDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNYNSQTAFQVAIIAGNFELAEVIKTHKESDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGEVQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDGDQENDISGPTAGRGSQSKISPSGPGGPGGPGPTPGPGPAPPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQYDTRHETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAILQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLIMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEILAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDTAREGRGIPPPPQTAPPPPPTAYYFDSGPPPAFSPPPPPSRAYDTVRSSFKPGLEARLGAGATGLYDSAAPLGPLPYPERQKRARSMIILQDSAPEAGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPSGLDYGPGDGPGLAFGGPGPGKDRRLEERRRSTVFLSVGAIEGSSPSTDLPSLQPSRSIDERLLGPGATPGRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTPVHSPDTDRPGPLFVDVQARDSERGALASPAFSPRSPAWVPVPARREPEKAPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSGLGAEEEHPGTPELAPAPTQSAVVAEPLPSPRAQPPGSTPTDSGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLPGPGPSPTTVPGPASGKPSSEPPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPAGGLGGLLDPAKKSPIAAARLFSSLGELSSISAQRSPGGPGGGASYPVRPGGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPAPGPGPGPGAPGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERALRQLEGS
The following text describes a protein:
Function:
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
Subcellular Localization:
Cytoplasm, cytosol. Cytoplasmic vesicle, autophagosome. Mitochondrion.
Domain:
The N-terminal region is essential for activation of the IFNB promoter activity.
Sequence:
MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLHAMVLLKLGQETEARISLEALKADAAARLVARQWAGVDSTEDPEEPPDVSWTVARLYHLLAEEKLCPASLRDVAYQEALHTLSSRDDHRLGELQDEARNRCGWDVVGNPGSIRTLQSNLDCLPPSSASPSGTRSLLRPIDGVAGWSQGRSLRSTDSPASLASNLEISQSPTMPFLSPHRSPHRPSKLCDDPQANLVLEPVPGGCQEPEEMSWPPSGETAGPQELPSSPPPALPKVAPDTTSTGLPETPTAPETSTHYPVECTEESAGAQSLPSPIVEPVKNPCPVKHQSPLQLSVEDTTSPNTKPCPPTPTTAKTSPPPPPPPSSAPCSAHLTPSSLFPSSLESSSEQKFYNFVILHARADEHIALRVREKLEALGVPDGATFCEDFQVPGRGELSCLQDAIDHSAFIILLLTPNFDCHLSLHQVNQAMMSNLKRQGSPDCVIPFLPLESSPAQLSSDTASLLSGLVRLDEHSQIFARKVANTFRPHRLQARKAMWRKEQDARALREQSQHLDSERMQAAALNAAYSAYLQSYLSYQAQMEQLQVAFGSHMPFGTGAPFGARMPFGGQGPLGAPPSFPTWQGCPQPPPLHAWQAGTPPPPSPQPATFPPSLPFSQPPAFPTASPAPPQSPGLQPLIIHHAQMVQLGLNNHMWNQRGSQAPEDKTQEAE