lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a low-affinity sodium transporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
HKT transporters are proposed to contain 4 pore-forming regions enclosed by transmembrane segments with each containing a potassium channel-like selectivity filter motif.
Sequence:
MHPPSLVLDTLKRIKLYIAMKLLLPNSEVPRIYWEKAQHLCGFLSMKLISRARCVASSVKQSYSFLVCKSNPLVVQLVYFVIISFAGFLALKNLKPQGKPGPKDLDLLFTSVSTLTVSSMATVEMEDLSDRQLWVLILLMLMGGEVFTSMLGLYFNNANANRNENSQRSLPSISLDIEFNSPANNGDHKITECGQSEETMSQNQVQQNKSITYNPCAVLVRIVTGYFVATVISSSVIIIIYFWIDSDARNVLKSKEINMYTFCIFTAVSSFANCGFTPLNSNMQPFRKNWVLLLLVIPQILAGNTLFSPLLRLCVWVLGKVSGKAEYAYILQHPGETGYKHLHVRRNSVYIVLSVTGLILLQVMFICSFEWNSESLEGMNWLQKLVGLLFQSVNTRQAGESILDISTLSPSTLLLFAVVMYLPSDASFLTANADNQPLTDKKTNSISRALWRNFTVNKLSCLAMFTFLACITERKSISSDPLNFNIFSIVFEIISAFGNVGYSLGYSCQKLLKPDATCKDASYGFVGRWTEEGKLIVILVMFLGRLKEFILK
The following text describes a protein:
Function:
Na(+)/Ca(2+) antiporter that couples the energy of a Na(+) electrochemical gradient to the movement of Ca(2+) against an electrochemical gradient across a membrane, which contributes to the regulation of cytoplasmic Ca(2+) levels. Mediates Na(+)/Ca(2+) exchange in photoreceptor cells and involved in controlling Ca(2+) levels during phototransduction, affecting magnitude of the photoresponse, activation kinetics, signal amplification, response termination, and light adaptation. Light induced depolarization of photoreceptor cells, resulting in Na(+) and Ca(2+) entry through trp/transient receptor potential protein channels, is essential for photoreceptor cell function but may result in toxic levels of cytoplasmic Ca(2+). Na(+)/Ca(2+) antiporter regulation of Ca(2+) levels protects photoreceptor cells from light-dependent retinal degeneration.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, rhabdomere membrane; Multi-pass membrane protein. Note=Localizes to rhabdomeres in a pattern similar to trp/transient receptor potential protein.
Domain:
Contains 2 Calx-beta domains. Calx-beta domain 1 binds two pairs of Ca(2+) ions. Binding of Ca(2+) induces a conformational shift that inhibits the Na(+)/Ca(2+) antiporter activity. Calx-beta domain 2 does not bind Ca(2+). Calx-beta domain 2 contributes to the cooperative binding of Ca(2+) to Calx-beta domain 1.
Sequence:
MQLLLKSIFTCALFVIFVYATAQSLLKVQETEARQAYLNVTSSSSSNLSQDDGHFLSRRLRQVSHGEEGDEGAPSQMDDELEQMTKVHGEAPDAEELRECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPKQPMVTSARGNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDELAAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVIRV
The following text describes a protein:
Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSDKPDLSEVEKFDRSKLKKTNTKEKNTLPSKETIQQEKECVQTS
The following text describes a protein:
Function:
Beta chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The beta chain is an electron transfer unit.
Subcellular Localization:
Periplasm.
Sequence:
MPKAFLIDTTRCTACRGCQLACKEWHDLPANVTKQRGSHQNPPDLNPNNLKIVRFNERMNEKGVVIWNFFPDQCRHCVTPVCVDVADMAVPGAMIKDKKTGAVLATEKSAKLSPADAKAVAEACPYNIPRIDPKTKRITKCDMCFDRVSAGMQPICVKTCPTGTMAFGERDEMLALAEKRLADAKTRFPKAHLVDVEDVSVIYLLAEEKEHYYEYAGFM
The following text describes a protein:
Function:
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Mainly nuclear. Relocalizes to the cytoplasm following interaction with PAK4.
Domain:
Contains 2 Inka boxes (also named iBox or inca box). The Inka boxes bind and inhibit PAK4 by binding a substrate-like manner.
Sequence:
MDMHSARLDSFLSQLRWELLCGRDTGSPSMPGPLQPTSQTGPDVQPSHQLRASGALEEDSVCCVEEEEEEEEEAVVTEDRDAALGGPREHALDWDSGFSEVSGSTWREEELPVSQRPAPSAQPLRRQCLSVSGLPMPSRAPVASVPPVHHPRPKSTPDACLEHWQGLEAEDWTAALLNRGRSRQPLVLGDNCFADLVHNWMELPETGSEGGDGGGHRARARPPQFLLGLSEQLRRRLARARRTAMAGKRLSCPPRPEPELPADVSRFAALMSCRSRQPIICNDVSYL
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MAPWQLFIFSLFCVGAAQQQAVVSVLFDPATGNITTVAEKKVAGAAAWAELTDSIQENGWAVLEVQTNDSFNDSIQAYAAGVAEAAVSQKLIFMHWMNTMMGYCGPYKYQAPFCEKLRSYLEANLAWMQDEMEKGQDQEYWHQIRLALLQLKGLEDSYNGRISFPQGRIHLNPFGFLFFQIGGDLEDLEPALNKSEPKRVLGSGSCSALVKLLPGNKDLFVSHDTWNTYQSMLRIIKKYTFPFRTTENGGPTVPGWVQTFSSYPGTIFSGDDFYLLSSGLVTLETTIGNSNDALWKYIKPQDSVLEWLRNIVANRLATGGQEWASIFKKFNSGTYNNQWMIVDYNKFSVGKTDIPSGLLTILEQIPGMVVVADKSDVLYKTGYWASYNVPYFPEVFNASGLPALVEKFGDWFTYDKTPRALIFQRDHSKVKDLESMVNLMRYNDFLHDPLSRCSSCDPPQNGENAISARSDLNTANGTYPFGAMSQRQHGGTDMKLTSYEMAKKYQMMAVNGPTWNQVPPFKWSTSPFSGLMHMGHPDLWKFSPITISWN
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MSGIPRSLLGQCAVALLGANARSGLTLHHAFAAYSSAAAPAQSAALIKQLRERSGAPIADVKSMLVEHGWDMDKAYEALRKKGLAAAAKKASRHAAEGLVGASFAASAASSGGSSSSEASTSGGGRGSVVVVELNSETDFVARNELFQKLLREVMGAAHALGPAAAVGPDHAMDLDQLMSARTASGPSVSEAVTALAVQVRENVRLRRAFRVDSGAGGLVFPYVHQAAAPGLGKLASVVVLAPEPDDKAQPLDAAGRGGAPLLAAGGGLAMHVAGMRPLYLNRAAVPAAALERERELLRQQLAADADFAGKPAKVLDKVVEGRLGKLLSDWCLEAQRYVLEDELTVDKLMARLKKEVGQPVRVASFLRVQCGEGLGAKAGGGDFAAEVARIVSEA
The following text describes a protein:
Function:
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAGIWAGYLGAHLAGLAFDGEGIGASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKTVGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVTLAPVLFVLFCVVIVSAWSNAVNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAGACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQILTFRTTGRRMFRMAPFHHHFELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA
The following text describes a protein:
Function:
Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.
Miscellaneous:
MISCELLANEOUS: [Isoform A]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform D]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform E]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim.
Domain:
The NTF2 domain heterodimerizes with NXT1 and NXT2; The RNA-binding domain is a non-canonical RNP-type domain.
Sequence:
MRRNTQDENMRKWFKVTIPYGIKYDKAWLMNSIQSNCSVPFTPVDFHYIRNRACFFVQVASAASALKDVSYKIYDDENQKICIFVSHFTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKITERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQSNLCKYFKDSRNIKILKDPYLQRKLLKHTKCPRNVDSLSALPETQHDFTSILVDMWYQTVNTCFLPRAGPESQRWWCLLSLKWKDGLRVLILPSCGPSSLPLAAIPVCAS
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDLQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGGDQSLQQGEGSKKGKGKKKK
The following text describes a protein:
Function:
Negatively regulates early endosome maturation by binding to and repressing the activity of 14-3-3zeta which prevents the 14-3-3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing.
Subcellular Localization:
Early endosome membrane; Single-pass membrane protein.
Sequence:
MDCFKVFEVVFQSEINPLLLIPAVATIALTLCCYCYHGYQWIRDRRTARIEEQQAQLPLPLSRISITPGCSMVATTKLTHSRNSVDIY
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MFVTPIEHAVQKRKKQKQRSVVDPVTRERQLKRNLADLEKDNFSDIRFEIPKDLLQRRVLPISVRRILSSRKTFVNYLDETPNSRYNTCVAKPSYKPPRKFCNVCGYWGKYACQNCGTSYCSKGCEVIHSETRCMKVYA
The following text describes a protein:
Function:
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
Subcellular Localization:
Peroxisome.
Sequence:
MLLKIRHALLEVTSPPAAKQSAIIINNELIISSGSILQPHLAVDGDKGAQNKAIVARLQRGQLLDVQNEEQEEDAQIRSLHFVATFDPQQRRPRPIAAPGSRQPHILSRFTAHPLYVFCANEVCRNLHHILLTADSGDAGEVLRSSFVVLGLRKPEKEKSFKRFLAHIANYLRYLQPMHTLDDVLVMCSPFGLENFYKTISIGKVSNVMGRSGCLFAISNALPLGCEGSAVFNNKLRLVGIVICTSFQRHHENVNLTLAANFGYLLRNFMEQLGMSTTAFQLSREPSSFAWERTIVVIESAGQQGTGTFIRVHNKRFILTCAHVVGQNIETVNCRAADREFQSEVIWCNPDSDKPFDLALLTAPQDVPEQCCVRLARSPATVGQMVYNAGFPYYVNFSFRHDFNPSIFQGRVIKCDTGAIMSDGSVQAGQSGGPMFDQNGCILGVCVSNIKLDDVVYPNINTAIPICDIRNTLQQFARTNDLNVLSNLVASPDVHRVWSLEMPPIRSKL
The following text describes a protein:
Function:
Involved in the biosynthesis of ascorbic acid.
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MRRLLLAGILRRASSSPSSHHHLHLVRALSASSPLPASDADLRKYAGYALLLLGCGAATYYSFPLPPDALHKKAVPFKYAPLPDDLHAVSNWSATHEVHTRVLLQPDSLPVLHDALAAAHGERRKLRPLGSGLSPNGLALSRAGMVNLALMDKVLDVDAKKKTVTVQAGIRVAELVDTLREHGLTLQNFASIREQQVGGIIQVGAHGTGARLPPIDEQVISMKLVTPAKGTIELSREKDPDLFYLARCGLGGLGVVAEVTLQCVERHQLIEHTFVSSADEVKKNHKKWLSENKHIKYLWIPYTDTVVVVQCNPPSRWRTPKFTSKYGKDEAIQHVRDLYRESLKKYRTKAESNDPEVDQLSFTELRDRLLALDPLDKDHVIRINKAEAEYWKKSEGYRMGWSDEILGFDCGGQQWVSETCFPAGTLAKPNMKDLDYIEELLQLIEKEDIPAPAPIEQRWTACSRSPMSPASSSQEDDIFSWVGIIMYLPTSDARQRKEITEEFFNYRSKTQTNLWDGYSAYEHWAKIEVPKDKDELTELLARLRKRFPVDAYNKARMELDPNKVLSNAKLEKLFPVTEVQHVK
The following text describes a protein:
Function:
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle. Early endosome. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.
Sequence:
MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGGGGGGGSPPCLVVREPNFL
The following text describes a protein:
Function:
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.
Miscellaneous:
MISCELLANEOUS: The active site is a redox-active disulfide bond.
Subcellular Localization:
Cytoplasm.
Sequence:
MDYDLIILGAGPAGYIAAEYAGKHKLKTLVIEKQYFGGVCLNVGCIPTKTLLKRAKIIDYLVHAKDYGITINGQAKLDWKQLLKQKQEVVDKLVAGVKTIIKGAKVESIEGEATVIDKNKVQVNNTTYTTNNIIVATGSRPRYLTLPGFEKAQQAGFIIDSTQALALEGVPKKFVVVGGGVIGVEFAFLFASLGSEVTIIQGVDRILEVCDSDVSELISKTLKNKGVQIITNAHVVRAENNQLFYTVNGVEQSVIGDKILVSIGRIANTECLDQLDLKRDHNNKIVLNEKLQTSTTNIYLIGDVNTQMMLAHYAYQQGRYAVDQILNQNQVKPAEKNKCPACIYTNPEVAFVGYSEMELQKEKIDYVKSSLPFIYSGKAIADHETNGFVKMMFNPKTGAILGGCIIASTASDIIAELALVMENNLTVFDIANSISPHPTMNEMVTDVCKKAIFDYFS
The following text describes a protein:
Function:
Transcription factor which regulates the expression of genes involved in lipid metabolism in response to nutrient availability. Binds to the E-box motif 5'-CACGTG-3'. Under well-fed conditions, binds to the promoter and represses the expression of lipase genes lipl-1, lipl-2, lipl-3 and to a lesser extent lipl-5, thereby preventing lipolysis. In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation by up-regulating transcription factor sbp-1 expression. Under well-fed conditions, acts remotely in the intestine to up-regulate the expression of chemoreceptor srh-234 gene in the ADL sensory neuron, possibly by regulating the insulin signaling pathway.
Subcellular Localization:
Nucleus. Cytoplasm. Note=In response to nutrient levels, shuttles between the cytoplasm and the nucleus. Localizes to the nucleus in response to high glucose levels.
Sequence:
MSAIVEDMYLLSSSMKMEKQFRKRHHSDSSDDDSSSPKSASPSMDDDRRAHHNELERRRRDHIKDHFTILKDAIPLLDGEKSSRALILKRAVEFIHVMQTKLSSQGKAIEDLTRKNELLEERLLERESSGSPSSSRLPALAVSSSQMQLTMPIIPQMQNIAQLSQYPQQANIIAQSTNPAQLDGLIALNNDAILALLGSFQSVSPSLLDSAPGTPPSGFYPCAFSPVDQQMAVKI
The following text describes a protein:
Function:
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.
Subcellular Localization:
Cytoplasm. Nucleus, nuclear body. Nucleus, nucleoplasm.
Sequence:
MAADIEHCNWLDISLETFTNFTEKPVKILLSDNRTIEGWVFCVDPVSKSVILSQNTEGAWSNSVVLGHAIKHMEIQQELEYQKPDFEKLYPYRQLEANGHDLEKRKSNVVRWLEKNRLSVTVEDELVCVLGVLCIEPPYNQESCRSSNVIILQRIQKLIQNMPVPEETV
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGKNKSSRKGKKAWRANISTEDIEDFFDNSTKDALSGGSLAQVPSDSLFYVDKSRVLSFFVGESFFSDQMTSFYVYNPDLSVKRKIEKHREKVLRYDSILQSNAFVEPVPSSTGKKSKKKSKLQIAKDTAQQGQKDSSGGDSGMVDIWNDKDELVIKTKKKPKTSVIPAVEVEPPGCSFNPPSESHQDALACAVADEMQKIYRNELGPEPIPLVVPGEVVNEEDVSLSCYFLVSTFDHGCCRCIMGYVFLYWVKYALKIHLPQMYFLEADSGSDTENENLVEDGKTDLDKRPQKPKMLTQVEKNRRARRKEQLKAEAEATKAAQLSKEIDSLPDIIQEIEREEGEKQKRHLRRVTAIKEKLKSCPPRLGKRNVDKKIIDLCDFRFVPAPAQVLLSEEITGSLRKLKGCCTLARDRFKSLEKRGLVVPSKKSSSVCEPCDTETIAE
The following text describes a protein:
Function:
The terminal oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex; Subunit 2 transfers the electrons from caldariella quinol to the bimetallic center of the catalytic subunit 1 that is formed by heme A3 and Cu(B).
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MDIKEHAEEVWFIVMLVLVLIFFSWNVYYLSTGKSFSLDYGLPTYSGLPEQAQKAVQYFDSHPPSPGQYSEVINGMLVVNLTATQYKWTPDLIVVNKSEPVVLIINSPQVDTGFYLRTPDGVINLNNVAGITSYAYFVINQPGNYTWRDAEYAGYNSSYMTGTVEVVG
The following text describes a protein:
Function:
Involved in the maturation of autophagosomes into autolysosomes during starvation-induced autotrophy. Specifically, involved in the clearance of apoptotic cells by promoting the delivery of engulfed apoptotic cells to the lysosome.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially localizes to the phagosome membrane of engulfed apoptotic cells.
Sequence:
MAELVRPKKPKHRERAQSDYTPPIPDRPAIVNGLRLPAAPSHTIEDLPERSASPEPEDQDISLTEDSLKREEASEPLKDVRSSPVRPAPPPPRVSQEREAPPIPPRSMIFPRSTSMVAESRKESTTAVAPKRSVAVASYPAVPELAELPSYTDALQHPQVYPSINGGLQHSHSATAIPEKTRFSAPVERERVREGEAPPMYPSIKTYERNEHGLMTEENLVTFYHNPLYEHAEMFVDQFIKTEEVPTQSGSLFPLLARLRTVCDLMTVSEVKGKENTEELQKCLRECWVQQSLSVDAKGKCGDNNDGTGRASYFSFELQQAVLDQMKKLLSTNRSNLMDHSVCEETSFRSIALQIQWQVIIINNNFMAENGLSTNCPPSLIASVPMTPGRVALRTALSDIFYHLRYPRLSKRFIDTLVGWIKELTCVLNMRQSCDDGIFLLCHLLRLPSPIDQWASPFVQTFIQSQSAPKLKLDYCVALLTHLLNPIKARESFLRHVAQSEKEESTWEILADDDDGEANEFSFVTINESDLTAFLDQFPISELYSIAYLAFTSYSDKGSQFTAMIAFQLLLMKILDNGLTSYSQPGYKMFCKQIGISLKHSVRELCSNWRLIRDQVRPGEEHHLQKEVDRVVLLALNYLIHQDTLGLFQFVVSLPYAVVSEECRSRCEYALRSNKKMSIHEIYDTPICEVRARISSQGISKRIGALGAQDSEFLVNSLASIGSYSNSDVSQLLKELIDVCFCDEDTRDDLYKCGGEAIGQILIKRPETLHQLLTIIDRNLQHMDSYAINVLSSSRLFECRLTEPMISIIGKWLINNPPEHGANRLARRVLSGLHWGLAVDGHNLWIDVDVHTIAADTVVKAHSVHCSRSNSMISKSINKISKLASKVGDAESLFQQFCWDLLVKLKLPTIPSSLVQNDLTAHYVRIVQNCEDDVVVYLEKGVPLLSDLVTSGSSVASVVLLSRLIAQHYQNVNLMAADKNFMTTFERLLHIDQLPYAVQWLSGPSSTPTPIVKLICSAISYYSAKLPPRDYLRAWITLLCAARTGWNEDAVTYQIVGTIARIAFVNDTHKLYEITGIIFQAYQQQLAAEKNQSKGIMSMFSSDNTVSPLIPDSMLSISPFASYVMLRVEQKSFNTFYGHFFETLTKKDKYTLDNAVKKASSKCSITVPVERLAIFRWAKLVTVCNDHQLLPILLQQLSGSAYRLRKANNLNLCYARRLIDDPQMQDVMAACRKAIEESTIETKGLSKAVVGWLFTKHEVTRTGFDFSVFDLDYLLQLILAGDKNMWLDFVNMPYFNSEEFSERKLYSVTCQLSPKNRESPLPPEIGSPRSRSSAKPFPVLPVHSGLPQAPLIDPSILFQQHTVLQLASPFINTIKQLSKQFAQSGDRMSMDDDSYCKQIKALYQPTQQTIPVEIRCSYCSKPKACTMSIKPNVLNSEIDLQMTQNRTKRFEFWNELYASIVDKAAVATASIEHLSVLVAKMTSALHPGTRNNVQLTGHSLFYLITSSVGENELLFSVASDSFCNSLRSLGEEYVKFRPEEQMDVMQLALDGFVLSEPLVEVFTPEVLNSDDLCTAYRKLSDAVRMPERSKMALQLLGRLGMQQAAAGLPPHQFAALLPIAFANLASQPDPSSPLHALCLQHVIFFVFHHFPDNIVNGLDLTLDGCNTNSTPASLLDAIVDKLDANDYLKKKNSFDLGAAKADECARILSKRLDEARTKLPNFYGIWSRYLDSVTRLAQLFLFVPIRDGYEPNKSVSVLQRECYEYFTRVAAVFSPLIAPYSPTHPPFSTSHEAQAMLVLDRFVDFLSALHFNSSIPPGMQNIQSLVWQYYCEKLSILTHGTQHYYDVIERQLVRLNWQALWPSRLAITAMENCLDTRSQDCASFISQMVARIPWSNILQTMHEDSRPSYLASLFGVLVRLAARPRNYDKVRASLLELCKSFSLRSDWNKIYPEDAAGIASAVTKCLPSDSLSNPVEMVSVIQVIWRKICCFVVREPFSEVSLQKQKLWIQTESSLLLKAESSQIPAAYNSLISDVNALALNHSNLREFRVVTRELTAMWKNITDAKLGEALVSIWSEYLAANPTSPLVLTSVNTLVDSLNIDQLTTALKVIEKVICAYFLRTDSNWAELLHWIQFPTGSLKSIKSYLMTVPSSENKVQMLPLTLKIFMDYGGVDENKFFDLHHYVISIRPKHVASESGFICLLARHLQWMANRSSALPAHFAPSDDLLSSLIKYLGKASKDESSFLTALISSKKTAYSQKMRVTLHILELYLTQQTLGEGKRPRCDANSPVLNSRISTLKDLAQQKSNQNMSNAFNKATAYFVQIETHRIQSSPKLLLEIGRSAFGDLFLTD
The following text describes a protein:
Function:
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Sequence:
MRIFISTGEVSGDLQGSLLVGALRQQAEEQNLELELVGLGGEKMAAAGLTLLANTAAIGSVGLTESLRFIIPTWQIQQRVKRYLKTNPIDLLVLIDYMGPNLTIANYLRKTYPNLPILYYIAPQAWVWSPTKRETAQIMAVTDRLLAIFPGEAEFFQKQGLDVTWVGHPLLDRITKEAPSRGSAREKLGIDHNETVITLLPASRIQELRYLLPSICGAAQQLQSQLPNVKLLLPVSLKDYQPQIEQTLKEFNLTVQLLEGKETLTAIAAADLAITKSGTVNLEIALLNVPQVILYRVSPLTMAIARRIFKFNLPFVSPTNIVLNRGIMPELLQEQATASNIAQAGLELLLNGDRQAKIAQDYQELREALGEPGVCERAAQAVLEFANGQQKSRA
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells; Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVMANNKPSQVKIGVVLDLDDDNCCGKIGLSCITMAVSDFYTIHSHYKTRLVIDIRDSNRDVVLAATAAMDLTKNVQVQAIIGPSTSMQANFVAQVGEKSQVPIISFSASRPSLTSIRNSYFFRATQNDRAQVNAISAIVQSFGWREAVPIYVDNEYGVGIISHLVNALQVAGTRVPYLSAFSPLASDEQILEELYKLKTTGTRVFIVHMFPSLGSRIFNKANEIGMTSENYSWILTDGMSNFLSSIDHSIFNSMSGRVLGVKLYIPNTKKLENFQARWKEKFNQDHQGMFNAELNIYGLWAYDATMALAMAIEKAASTATFGFETKKFSSNSLDLETFGVSQNGPILIESLANTSFKGLTGDFIFVNQQLQSSNYQIVNVNDVGLREDGLWPPKKGFVSKLSLASSLQAVASTSVSKKLRIGVPNRAFNEFMNVERDAKTNATIYVTITERRSFYVDFTLPYMEHGGVSIIVPIEDHRTSRSWVFLKPLTWRLWVTSICLYVFIAAVLWVLKNRNEELQGSPSRQTGTRFSCSAIVFPHKEKVARNLASITVVIWCILGFVLTQSYGAALSSFLTVQQLQPTVNYVTELIQKREKVGYQNGSFVFGVLKGLGFHDSQLVSCSPAEQCERLLSKGSKHGGIGAAFDEMPYTNLILAQSCSKYSLVQPILDIQQFKTNGFGFVFPKGSSFAVEVSRAILKLKESYQMKKMEDKWFGKQKHCSLHASDVSVSTKLDLDSFQELFWIAGVASSLALVIYTGLFVHEHRQVLTPPYSSASILSIVQDLLRIINRKDSNFNSAEHDLAFGKIFNQKENHTSGKNAVDIERDLNLPDSRATNAPTVSITAESPGEQGATSSENPDPSLNWKTPTDVVPHIELRNPNQERQTSSKTIQENR
The following text describes a protein:
Function:
Participates in the breakdown of the egg envelope, which is derived from the egg extracellular matrix, at the time of hatching. Thus allowing the newly hatched fish to swim free. HCE binds tightly to the egg envelope while it exerts the choriolytic swelling action.
Miscellaneous:
MISCELLANEOUS: In medaka the hatching enzyme system is composed of two distinct proteases, the high choriolytic enzyme (HCE), of which there are two isoforms, and the low choriolytic enzyme (LCE).
Subcellular Localization:
Zymogen granule. Note=Stored as proenzymes in the zymogen granules.
Sequence:
MNLASSACLLLLFLLGIAQALPVQNEEGHEEGNKEGHGEEGVEEGDEDDFVDFTTRILTSNNNTDQLLLEGDLVAPTNRNAMKCWYNSCFWKKASNGFVVIPYVISSQYSRGEVATIEGAMRAFNGRTCIRFVRRTNEYDFISVVSKNGCYSELGRKGGQQELSLNRGGCMYSGIIQHELNHALGFQHEQTRSDRDSYVRINWQNIIPASAYNFNKHDTNNLNTPYDYSSIMHYGRDAFSIAYGRDSITPIPNPNVPIGQRNGMSRWDITRSNVLYNCR