lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFLLCLFLDYELCVDISIKGEIVSNQFCKMCVVRIENKDLFADLHILYIGVYTPLRVVFALQARRLVQSGCKRYLNVVIETRMKELMIEEIPISKALYSMALMESKEATQRDLAVRLYMQVHVLLPMLNGKSSCNAQSRNLILHLAKRIISSPKACPILVNGAVRKGKRLVPPSTLKLLMRIAFPAPLARVKVIERFKAIYLTLKEVTFVDSPKSKYLIFNSIAGVCDVFIWCLTQNPKCYKQWDAVMMEVIVLFSWKRSISLRVLYRLMMQGVMMLV
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase.
Sequence:
MLIRAPSYIFNSKTRTIYSAAMELQQHQQEQARKTVADKWLKPHGPPVGATFGARVLKDEDDVFNHNAWDHVTLPEDFKERAEKVMELHRSSPVAEEKRDEYNDKPAHYWDKFYSQHEDGFFKDRGWLRLEFPELVACSEADAGPKTVLEVGCGAGNTVFPLLMRNENPELNVYATDYSATAVKVVKANKMYPKAEHGLGTMHASVWDITSTPPPPLVSSSSTSTSPEDQLSSLSIEEQPTYSLPEGITPGSVDVISVIFVLSALHPREWKQAIHNLYTALKPGGLLLIRDYGRHDLAQLRIKKNRLLDPETPNLYIRGDGTRVYFFEKEELEGMVLQPPEGRVEGRAKNMFEIQQLGEDRRLLVNRKERLTMYRIWMQVKAKKLT
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATSEPKVPVYSINDLKSTTDDALVPYLCTLPQPYTFKQDHSKSNVRFLLGYSAVAIAAFTFYADRKLGWEATTSPWVIAAVCSYFILNTGLTFWIWAVEAGEVFRGKRESGETISIRSSVKKHSPLYKLRVQYTSPSNKILQEKEIDAPFMNWFSADGTFHPEPLRRWLSTEIEVLRLAAKETERKTGGVGSVVGVQDTKNKK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein. Nucleus.
Sequence:
MDFKISISIPPDNPPVAQVDHAGVEYPSIQISKSDKFIQILNQAKHQKEIEQIKLNDNKNNENNNLQDKEKEKEKEKERQLQIQQQQQQVNPMISFHEHKNMARIELEQLIYLIDMLRNSDQIQLNGNTKTPQKPIEQIWEITHRISHKQQSLNNVASKLKLGATKMKDTISTMSGWWNDVSQLRTKWRLKGKEQTGLSSAIANSMSGGGGGGGGSGGVGGVGVGGVGVGGIGGVVGGGGLGNVGGLGGGIVGGVGGVAVGGVAVGGMVGANGGGMVGSGGIQPGLNKSNAKRLSIDYGYYSSGSFIEQTDADLSRGPNGEINIDFPHLPYQGSINKRLYINVKSSDSKTFFNHSSNLKKLPSIPYQQLLNSATNSNNNSNRVNTPKTPTSSFPSTSSSAFNKLRQQQLQQLQQQQQLQLENSDDPEEIHRKFIINCTNQLNKAQKYQFNYEIFEQLSKEVSTINTSNSQNLIGGGIGGVNIGGGNVGVGGNVGGNVGGGGGGNTNYQTSPNIPSNQQVGTFQVGGSGVGSNLITMNPSLNANTSSENIMLTEKEIRIECGNFNLFIGMDTKVKEDNNNNNNNTNSNTNTNCKIKNNTSKNIIYSDEEKNRLLFVLKTILKKISVMQLKRSQKQLTFNLSRRTPKIIFGKKSIIGYNDDIIFKITSIVKHMDTYLRVYKVLEIFERNLPIRLKSTPAAESASSLFILTLIDSSQNLKNPMVPIEISINQNKIEVIQGQNRSFSNKDEIILGSFIINLLKSYFLNNNIHPSHLDIVGFDENDEQDQNNINNNINNQPKRYKFSNDQSSIILANNNNININNNNINNNSNFDDNFIKSNRNYQIEKFFKGLVDEISNK
The following text describes a protein:
Function:
Canonical brassinosteroid (BR)-biosynthetic enzyme capable of converting cholesterol to 22S-hydroxycholesterol via sterol-C22 hydroxylation.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MEGLLLLLPTAIIALYLYISLIRRSRKKHNLPPGSDGWPFLGETFSYLKPHSAISIGRFMEDHISRYGKIYRSNLFGEPTIVSADAELNRFVLQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRDMRMISLNFMSAARLRTRLMPEVERQTLLVLRSWREGSTFSAQEEAKKFTFNLMAKHIMSMDPGEPETEMLRREYITFMKGVVSAPLNFPGTPYWKALKSRSSILAVIERKMEERIGRRDRGDGGVEDDDLLGWAMNQSNLLKEQILDLLLSLLFAGHETSSMALALAIYFLESCPEAVRDLRDEHLAISMSGKEGECGLSWDQYKQMEFTHCVINESLRLGNVVRFVHRKAIQDVQYKGYDIPCGWKVLPVFAAVHLDSTLYSDPHRFNPWRWQSSSSKTTAANFMPYGGGLRLCTGSELAKLEMAVFLHHLVLNYQWKLAEPEQAFAYPFLDFPKGLQIKVRAIT
The following text describes a protein:
Function:
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Postsynaptic density. Synapse. Note=Postsynaptic density of neuronal cells.
Sequence:
MGTAQVLPGILQKHCCILPDRNTESQCTLCGEPEEEEGGDLAQPGLSFPGPAEEDIDQQYSWSPTQHFNEERYSPAPRNMKGLTGSRNQPQLCAGHTCGLSPPDDCEHPHDHMHHGSDVRQPYLLSPAESCPMDHHRCSPRSSVHSECMMMPVMLGDHVSSSTFPRMHYSSHYDTRDDCAMSHTSTKVNRIPANLLDQFEKQLPLHRDGFHTLQYQRASAATEQRNESPGRIRHLVHSVQKLFTKSHSLEGSSKSNINGTKSDSRVDDHHQSHLSKHSKRSKSKERKPESKHKSGMSSWWSSDDNLDSDSTYRTPSVAHRHHMDHIPHCYPEALQSPFGDLSLKTSKSNNDVKCSACEGLALTPDTRYMKRSSWSTLTVSQAKEAYRKSSLNLDKPLVHPEIKPSLRPCHYLQVPQDDWGAYPTGGKEEEIPCRRMRSGSYIKAMGDEESGESDSSPKTSPTVAIRPEPLLKPIIQRPLGDHQTQSYLQAATEVPVGHSLNPSINYNSPKFRSRNQSYMRAVSTLSQASCVSQMSEAEVNGQFESVCESVFSEVESQAMDALDLPGCFRTRSHSYLRAIQAGYSQDDECIPVMTSSNMTSTIRSTAAVSYTNYKKTPPPVPPRTTSKPLISVTAQSSTESTQDAYQDSRAQRMSPWPQDSRGGLYNSMDSLDSNKAMNLALETAAAQRHAADTQSSSTRSIDKAVLASKAEELLKSRCSSIGVQDSEFPDHQPYPRSDVETATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQADLELEGFPGHVSMEDKGLQFGSSFQRHSEPSTPTQYGALRTVRTQGLFSYREDYRTQVDTSTLPPPDPWLEPSLDTVETGRMSPCRRDGSWFLKLLHTETKRMEGWCKEMEREAEENDLLEDILGKIRSAVGSAQLLMSQKFQQFYWLCQQNMDPSAMPRPTSQDLAGYWDMLQLSVEDVSMKFDELHQLKLNDWKIIESPERKEERKIPPPIPKKPPKGKFPITREKSLDLPDRQRQEARRRLMAAKRAASFRQNSATERADSIEIYIPEAQTRL
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MAVEQRDTATVRVSNIPRSVTAKDLLDFLERHTGKSTVFACEISSDHKNWKSRGFGRVQFETLGSKSKAMSLSRQGALCFKGFNLSLSHSLDDVIFRPVDPHNRFEQGFLRTGLLPKMDCMCVLESWEGVKTYVLPERKSLEFWVTHSGDFYRLELQFSDVLEASPCCIDSEEPIAVLLKLKHAPKLYQRLSGSKVSPRFTSDRYHICKEEFEFTWVRTTDFSSKKSIGQSSTLCLEFKHGSPALDSFKTLPFYIKDLIKLSMREGQQFHTSSDIVPLIKCPPELNLPYEILFQLNSLVQTQKLSLPSVDHDLIEFIISQDSESIMTILKRMHKSHVTCYNPIEFIKEKLDTKGKTVKIPDTKSTNQNKIMSIHRVYITPSKIYCLGPELEASNYIVKHYSEYSSDFLRVTFVDEDWGKIQPNVISINLQQGIFAKSHHTKVYHRTLDIMQNGVTIGSKHFEFLAFSASQLRSNSVWMFASNKHVTAESIRKWMGCFTSIKSVSKCAARMGQLFSTSKQTIEVLPHHVEVIPDIEVKTDGVDYCFSDGIGKISLSFAKEVASKYGLKHTPSAFQIRYGGYKGVICVDRNSFKKLSLRKSMLKFDSKNRMLNVTKHSESQSCYLNREIVTLFSTLGVKDDAFLALQDLQLKVLNAMLYSREDALVVLDGLGNYDVKDILVKMLLQGYEPNQEPYLSMMLLSHHDNLLSDLRTRCRVFVPKGRILVGCLDESGVLDYGQVYVRITLTKSELRFRDQKFFKKMDEATSVVMGKVVVTRNPCLHPGDVRVLEAVYEIALDEKDYKDCIVFPQKGERPHPNECSGGDLDGDLYFVSWDESLIPPRTVTPMDYTGRRPRLMDHDVTLAEIGKFFVDYMTSDTLGAISTAHLVHADREPEKALSSKCLQLATLHSMAVDFAKTGAPAEMPRGLRPHEFPDFMARWDRPMYISQGPLGKLYRATKESEHLKNSASAYSTESIQDSYDQDLEVNGFKELTEMALMHKEMYLDALTSLMNYYEAETEDEILTGNIRNKSSYLQRDNRRYGETKDRILVAVKSLHREARGWFEGACKAEDHQKLAAAWYHVTYHRDYCNGSVKCLGFPWIVGHILLEIKSINGRNMLM
The following text describes a protein:
Function:
Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Involved in disease resistance pathways.
Subcellular Localization:
Nucleus.
Domain:
The AP2/ERF domain binds specifically to the 5'-GCCGCC-3' motif. The affinity of this binding is higher if the seventh amino-acid of this domain is basic (By similarity).
Sequence:
MYGQCNIESDYALLESITRHLLGGGGENELRLNESTPSSCFTESWGGLPLKENDSEDMLVYGLLKDAFHFDTSSSDLSCLFDFPAVKVEPTENFTAMEEKPKKAIPVTETAVKAKHYRGVRQRPWGKFAAEIRDPAKNGARVWLGTFETAEDAALAYDIAAFRMRGSRALLNFPLRVNSGEPDPVRITSKRSSSSSSSSSSSTSSSENGKLKRRRKAENLTSEVVQVKCEVGDETRVDELLVS
The following text describes a protein:
Function:
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
Subcellular Localization:
Secreted.
Sequence:
MKVSLSFLLTILIVIITIKVNLSQEIKISPFFANNLKFEPIPDYIEYDSDSDAGEALFLSNYLDDHKTAKQKSCVDIGAPFQSCDKLLEIDSNLRDTEDFFTFTGFITVNETYNSNTFFWFLESQNGDKNSPLVIFLQGGPGGASTFSLFVETGPYELLDNFTLVQREITWNSEFAMLYIDNPVGTGFSFTDSQEGYSNNEDEIATNLYTFLQQFYKLYPEYYTNELYITGESYAGKYIPAFSYHIIQQNQNSNNPNINLKGIAIGDGLCDPITQVTQYANLAFYTGLADLQQQEVMFEYQDKIVEAINQEQWSVANDLFTDLINGPPDYFQNITGESDYYDIRKTVEPTYGGDFTAFLNQSSIRAMIHVGNNYFQNNNDVYIHLEQDIPKSVKQLFPTILDNIKVILYNGQFDFIVGPSLTETMIRTIEWEGIQPFLESPKIIWKIPSDNVDVAGFVRQWNSFTQVVVRQAGHMVPLDQPARAFDMIDRFINNEPFPSG
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MESGENKNISEMLTLSGSYGDEQDSSGHSPRTSGVISDWSEVNRQLRHHGFHAVMVLPRQHISEIPAGAVILEEHTSQHLRHTLESLMSDCDRRQALVQELISASNRLQKDNKENAEIIYSYETEIRGLEQQLETERIKVQEYEDRHMSELHRHGEEVQDLQLGKDEVAVMYKQMEQKLQKKDEETSRLQKRCHDLVHKEEERLERQRLMFKHFKNRSPRKQSDVDQSENGLLGHLKIVLGQSEWLFYWILDIVDSYEAQIDELKEEMEQIKKENKALSASYIGTYGDVNDDNRAMHKDVSDVSDLASGETSEDDNARHSRSPLEAGSRTGMAGKWRSSQSSSPASSSPRRVKELTDKNLVSYHNSLCFCVFAKPKGCGDDFRFYERQLKDAKKLIRLLENENTNLKVDLQSRPRTEEWKKTRKYNKKLEKLLAQNNLSPPRKRHLLTDRDVPVETKRCSTNVGDIEFLPIDVCREYIKAHRFLLFCDRDPCCKASDVVNAVGKLSKARHLLKVDDLPGLIQRLEQYDEFFPAFQEMVTELCRLLSKSSLQYKNEAHCAVTCLVTPSKMATTKQNEVCSRLEVTDLKQLTDRLDSIDVMAEAYPSMEKLISDILSLTQEKGALVVSAEDMSQSVDSHALYCQRAWQNILPTLRLWHKELKHMKDLQTAVDHLAVSLMPWKPDNMFRADDRKPLRMRDLRARIESLAYQGTRALPSELRGSDKPSAEQLQSIVAHFQKLFDVTSVSGVFPRMNELYLRVGEVYNAMNTMRELLNLDPCCKASDVVNAVGKLSKARHLLKVDDLPGLIQRLEQYDEFFPAFQEMVTELCRLLKTGSNVFLSSNKVTIKTGTVLMFYFFSLAVEKMDEIVTAVRALIKFPQY
The following text describes a protein:
Function:
Involved in cell adhesion. Thought to play an important role in cytokinesis B, probably by providing substrate adhesion and traction forces. Required to organize and polarize the tip epithelium during cytokinesis. Required for the normal distribution of myosin in the tip epithelium. Involved in the localization of ctxA, ctxB, dcsA, exoc6 and rgaA. Thought to form a complex with ctxA, ctxB, and rgaA which regulates myosin accumulation to the apical plasma membrane.
Subcellular Localization:
Cytoplasm, cell cortex. Cell junction. Note=Localized during interphase over the cell basal surface with levels decreasing at the basal surface when cells enter the mitotic phase. At this time, there is intense localization along the polar edges. Also found at cell-cell contacts in the slug and fruiting body and in columnar cells of the tip epithelium.
Sequence:
MDEVLEMIADAVSSLVVAITDSEEKNTLFGDMVPGVELIQQAVNGMAEAAEETVSLIDEEFIGQLESTSKQLKNSAGQLYVHAVRAREDPWNRVPQKDAIKAAKQILQNVVLLVLIEEQSNIKVLVNIAKKAAEGVRRIDEIENIKQLDVMIGDVNQLQNELVKRSQRRSEGSHNPELRSKLEDIATMVNILSEQHQASARDVCRNPREETLRSKRSELSSKLLSAIDDLIYTIKLIFENNTKFVDLAFKWKPVRTMAEDEVTRASAVLIDNLRTLPKSIEAGNGPAAAREIVNAANLQISNAIIVANRCQDPVKKKMLLKQIEELKKLTPMLISAMKPVLENPNDQEAQKHLESVIYSTQKASEALATAVVSSPAEIVAASGVSLARDLDSLEEAIASGDKKRAQVILSHIPSAIDKHIELANALLETITDPGQRHQIKQSIERLQTLKPRIIENANRAIANPNDHEARKNLSSDIKEAKKAIGQISQPYEVVSALNTKIHNDLDSLIKCIDEGGPDMQVKGVQYAKDIANSIKKQIEAAEAYAQTITDPDRKKQVLDSIEQLKKLTPQLLEAIRACLANPDDKEARKRLDDVVRRVKEASSNLSQVIQPTADELKEEKRKRNEEIARIEAEEKAKARALLKAAELARIEAEEEKKRLAIIEEEKKRLAAEEEERKRAPKLVVPEGPVNKAVFGAAADVAQALESKVRDGTPLGILVQLSDEIAQQMALIASFAMNGDVKGMITAARKIADTIKQVQTQAKHIADNCTDPRLKQNVLTYCDCGGNFSTQLKILCAVKSNDFNDPTAEEQLVTCAKGLSGAVINLVKSSEAASIKQRKVPQQ
The following text describes a protein:
Function:
Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.
Subcellular Localization:
Nucleus.
Sequence:
MSCQAFSADSFTTLAGDSLPLLMHHASAADCLPSSASTHTHNMVSAVPSGLSLLQSSKRSHMHLSTSTLGNALSNGPPGLHYPVTPCHYSNQQTTYGMMAAQEMLSASISQTRILQTCSVPHPNMVNGANTLQGSLAPCLYKFQEHGLGGGSCSLSHSFPPLPPAVLSEESPLGGNKDLRLRSRPPDDPPNMDSPQIRELEKFANDFKLRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACTLKAILAKWLDEAEQAGALFNEKMGMNERKRKRRTTISLGAKEALERSFGEKIKPSSQEIVRMAEGLHLEKEVVRVWFCNRRQREKRVKTSLHHSSYLTKDSPTYR
The following text describes a protein:
Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor.
Sequence:
MNGDEQNKKKLRSDAMFGKINQFVTLQKDETAKYNSLFTKVTESIVSILKEKDEVFKKYYRNTMYAGSFYKQTRVGQPKEFDLNLILCLPDIDSVKIEKGRPGFAKIKFDERKISSVWTEHKVLNKWLDSEGYLDNGKLRGWFEGMVKKSLNPSEKNSNKFRIYSKDSSSPLCEAEIKKSGPAFTLIVNDGSMEFAVDLVPVLEFSQSPPLSNFEKLKEPWHLVPKPLKNGDVPNQNWRYCFYHYEKEMLKKNGKVKPIIRHIKKLRDTQNWSILASYYIETLFFHVLSKNDFDQNESQTRLLVYMLKELSKAFKSGLLNYFWDKTFNLFGELTEDQIVGVQNRLDKIIKEIEADPTTMTQYFLTKEEQKKLKEIEEKEKTQPKKEVNVDKTNGLSSTFPLIRETKSEKNKKIIQESENRETSKNEIKALKEMVLSLKAEFKDFKNSIKQKPIDQTPETEGTDEKEMKKLLLLLINEVKQLKLNVGRLETKIDQTNEQIKNIKSQSTFFDVMETGVPLLN
The following text describes a protein:
Function:
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity).
Subcellular Localization:
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Sequence:
MSNLSFFQTLSGLAENAKQIAKSSSLSFEENELSHSDLLRLLNSNSDAGKLEAINFILAQMMHGENMSLYFPDVVKLVASENPEIRRLVHIYLLQYAEFNPDLALLSVNTVQKTLYDKNPLTRSTAIRVMSSIRVPAINGIVLLAIQQCITDTADRVRQSAALAITKCYSLDPSYKSQLEEHIKTLLSDNSPIVVPAALFTFEVVCPEKLEIIHPYYHRICTLFPQMNDWDKVVALKTLVRYARLTLPEPSTPSTHSDLKELLESIKSCFFSLLPSTIIAGARAFYYLAPSNQMHLIVEPLLQLLLEKPIVRTTTLRYISQIVYKTPELFKNHIKSFFLIASDSDDTCLLKINILSRLLDAQNSSQILPELLYYINSHPNPSVASTAVKALGDFASANISMAPSCLNTLLLLLKSHNSLIVTEAASSLRLLIHNDPKEIYLQYLAATYETLEVPRAKSVTLWLISEHILIIPRLVPDVLRIAVKTFADETLEVKYQILELSVRLYVLSHSEEKQNDLESRDDVVSLLFNYVLSLIHFDMSYDLRDRARFYKELASTPSSEFTRRIVLESKGNSQKEIIASRDYCIGTASLCLNEDVMGYEPIPNWADVSDLPPDSVREGIKDVLPINPHTGNIYSNNSPGVKALSSDNFKRDFGDTNAINRPKFVGQQTLEEFYASETSESSEGEYETSTSESEDEETDDTSQEEDNEKNSTPDEDTENNNTSSISTKSIMDRPLTEPEPNYWQS
The following text describes a protein:
Function:
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
Sequence:
MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDVRVRDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNTKNNARTRKGKAVAIAGKKK
The following text describes a protein:
Function:
Matrix metalloproteinases (MMPs) or matrixins may play a role in the degradation and remodeling of the extracellular matrix (ECM) during development or in response to stresses. Can cleave myelin basic protein as well as fluorigenic peptide substrates, McaPLANvaDpaAR-NH(2) and McaPChaGNvaHADpa-NH(2) 4-fold more efficiently than McaPLGLDpaAR-NH(2) (QF24). Active on myelin basic protein (MBP) and, to some extent, on McaPLGLDpaAR-NH(2) (QF24) and beta-casein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Domain:
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MSRNLIYRRNRALCFVLILFCFPYRFGARNTPEAEQSTAKATQIIHVSNSTWHDFSRLVDVQIGSHVSGVSELKRYLHRFGYVNDGSEIFSDVFDGPLESAISLYQENLGLPITGRLDTSTVTLMSLPRCGVSDTHMTINNDFLHTTAHYTYFNGKPKWNRDTLTYAISKTHKLDYLTSEDVKTVFRRAFSQWSSVIPVSFEEVDDFTTADLKIGFYAGDHGDGLPFDGVLGTLAHAFAPENGRLHLDAAETWIVDDDLKGSSEVAVDLESVATHEIGHLLGLGHSSQESAVMYPSLRPRTKKVDLTVDDVAGVLKLYGPNPKLRLDSLTQSEDSIKNGTVSHRFLSGNFIGYVLLVVGLILFL
The following text describes a protein:
Function:
Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (By similarity).
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
Sequence:
MLQVVLGAPQRLLKEGRQSRKLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFKDSNSSLHRGPSVSSQQALTSPAFSTIFSFFDNTTTTVEEHVPFRVTWTNGTIPPPVTEASSVPKNNCLQGIEFLEEENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQLCILWPSKVSPESAMGTSLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVQVIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEKRAILSQECPTETQMYTFQKPTKAFPLGENSDDPSSGE
The following text describes a protein:
Function:
Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSAKSRRPGTASSQTPNECVQVVVRCRPMSNRERSEGSPEVVNVYPNRGVVELQNVVDANKEQRKVFTYDAAYDASASQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDDLMGIIPRTFEQIWLHINRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGVYVPNLHAINCKSVDDMIRVMKVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIAPQQQQRSEKQGTIKKQRVKKPKKEPISQELIGSALQASSADLQVDEDRDSDGDGAESESDKENEAEVAKSNEELERERVENAKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKHDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSFPLPLPPSGGDGRQGYRRPVSHPQRRRPTSEHALQEAKSNAPSSLRFKSENIVSYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIVDSHTNSLRSRLENIINANSSSNGGPGSGAGPLAANTAGSGVGSMPNVRNIKSSRGLPSAGTALDSNRRPPTGRIPAKKPASAYPKARGLVNK
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MKRKEKLPSETGFEGWGDYMDAKIAKLEDQFRHSSANVGEKQSDLFAGVSIFVNGYTNPSADELKRLMMMHGGVFHHYKRPNTTYTIATILPDVKVRSITSEIIISPRWVVDCLKEGKLLDYSRYLLYTQHKPSQPKLAFSKLLAPSTSRTTDITKPVVKNDGDPNDISRTECLNVLGMLKNFSNMAPEPTVSFESEEQTKSCDIPVDTTPTKAVPANVASPQSTSNGQETSSQPSPQCSPDVFAEEEPPPAESSVQSSATVKSPHKATTSKQSLTATDPNFLTEFFNNSRLHHIATLGAGFKQYVAELREKATGSFPARDTLVERLCPAGARDHPECDFSNESNARYIMHIDMDCFFVSVGLRKYPHLRGLPVAVTHSRGSEARVPSHPGQNRALEIELYHKRLEERYKAPDIPIESRLAAIDEHNSLSEIASCSYEARQCGVKNGMFVGAALKLCPELKTIPYDFDGYREVAHQLYDTIARYTLDIEAVSCDEMFVDLTELLQSTGVGVMEFVTYVRNEISTATGCDCSAGIGANRLQARMATKRAKPNGQYHLVPGAVEEYMKVIPIAELPGVGPSTSHRLRKMTYVTCADLQTIPKNVLQTEFGKKFGETLYNACRGIDERPLVYDRGRKSVSVDVNYGIRFSTEQEVERFMRQLTQEIHRRLVELRQRGKLVTVKLLVRSPEAPVETAKFMGHGLCDVVTKSQPLRQHTDDRGMIEGAVLGLMRMLAIAPSELRGIGIQISKFEGTKHAANSEAGNRLKSMFQKVEDKRKPAEETVTMVTNDGAMVAESSRQQHGAFYQPDDQQPCTSRSNSAVQAIPPAVRQSYITPTKSDYSGPIISPKRTDNATYSPSRKAAGASKPSTRGRRGRPPKWASLSGRKDPAKTTQSVGVMRKFLIGAAGSSSSGGSELPAGLDPEVLAALPEDIREEAIRDYRRQQQQQQQQLLATNNRLQPAVEKTPVKVSPARDTARREWQSPVTPQHTASADTESDQKIKVDLKFLQALPLHLRLEVEKQIELNKDNMVVTCNEPEFEEPLLVTPDSSPAKELRTPTKGVVVAAAPDVASTEPSRDPNILRRKNWRELVEEWINSAEEPYEYDVLLLAENGLELLSDNKSLDQLYLFLRYLHRLVKETASCFWHRAYCSVVRPIQEQMLTMYGRRLAVPGNIDCELCNEND
The following text describes a protein:
Function:
Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass type II membrane protein.
Sequence:
MSFNKVPNIPGAPALSALLKVSVIGGLGVYALTNSLYNVDGGHRAVMFNRLTGIKEKVYPEGTHFMVPWFERPIIYDVRARPYLVESTTGSHDLQMVKIGLRVLTRPMGDRLPQIYRTLGENYSERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTERASNFDIALDDVSITTLTFGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDRRSAVIRAQGEAKSAQLIGQAIANNQAFITLRKIEAAREIAQTIAQSANKVYLSSNDLLLNLQEMNLEPKK
The following text describes a protein:
Function:
Transcription factor that specifically regulates the neosartoricin biosynthesis gene cluster.
Subcellular Localization:
Nucleus.
Sequence:
MEKSNRRKRPSTPHLSCELCRERKIKCDKVDPCNNCVSAGVVCIPVHRPRLPRGVHARRARPMSPTFVPPRAPTPVAGPVPSEKKQTDHSSGAVAAVDDDLRRRVHRLEAVVNSMRAAMQDSSPATVKQVSCEYWGIVGRADEEKSVLNDSYPAPTSSLACNASIPMTVQGQPPFESRPDCFWNNMVGEIEHFGGDVGSSSETKSDDHSSLAPNMPRMGDGGLRFLGLSGNNPTLTWTPVLEGKEMTRQLCQIYLQQVDPIIKILHRPTVEKWMLHGERYLDYPERHVAVDALRSAICYATAASLTDDQCSAIFQRSRSSGIVEDFRRECETALERSGFLVSPSITGLQAFVLYLIARRSEDRGQAAWTLTAVAVRLAKALGLHRERDETFFNQQMRRRLWLTISLMDLQASFSQASEPLISTEEATSTFFLPKHINDSDLDPTMTHEIPDREGLCDTTFALVTYHIQLAGRALNFGTTASPQHKASQQQHAQRFEENALRLLHFCDPESSPYAWFTWHGTQCLVSGARLSALRPLQLPQPSNGSSQPPSSPSPRPQEHNHELLRLALNVLEKAHLMHTDPRGEGFRWYVTMPWHALAVAINECSLSPDVVRIQSAWPTIEACYQLLRRKGVAGQEEAIQRPLEKLICQARDKASPLLQLARSSPTFSLGSSTGTSAAPTPRSRASSTPSDTLSDLSWPTAFSHAPSQLGMELAPVGPVQPFAKLDLDSLLSQFDIQGQPLLAGQIPPVDAELSLRTWEQLMSDIDAESNQLLP
The following text describes a protein:
Function:
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.
Subcellular Localization:
Nucleus.
Sequence:
MTGTERKVFQKYYPPDFDPSKIPRAKGQRNRQFVQRVMTPFNMQCNTCHEYIYKGKKFNMKRETAEGESYLGLKIFRFYFRCPNCLAEITFKTDLENCDYQNEHGATRLFEAVKLYQDQQKQADEQEAEDAKDPMKMLEKRTMQSRQEMEEMGNLEDLQESSRTKECVDTIGFLSSTDPHLAQAQRIKMMEDEDDRMARELMGITSDGRIERRIKDYDDDEDDDKDEEKDVPGPSTWAASMLKPAIPALGMEEATNSRKRFDQKDRFAGIKLIKKVKPTEPTTSSATTSSAPTTSTTPSASKPSTSQPAPSGLSLLAGYGSDSDSE
The following text describes a protein:
Function:
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
Subcellular Localization:
Nucleus.
Sequence:
MRVKIKCWNGVASWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWLNSQQIQQHCPMCRQEWKFKE