lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain (By similarity).
Subcellular Localization:
Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity).
Domain:
The cytoplasmic domain is required for SH3GL2- and SNX9-binding; Disintegrin domain binds to integrin alphaV-beta3; The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence:
MRLALLWALGLLGAGSPRPSPPLPNIGGTEEEQQASPERTQSRSLENQVVQDSPPINLTEVLQTGLPETLRIGLELDGENHILELQQNRDLVPGRPTLVWYQPDGTRMVSEGHSLENCCYRGRVQGRPSSWVSLCACSGIRGLVVLSPERSYTLELGPGDLQRPLIVSRIQDLLLPGHTCAPSWHAFVPTEAAPDLLLEQHHLRRLKRDVVTETKIVELVIVADNSEVRKYPDFQQLLNRTLEVALLLDTFFQPLNVRVALVGLEAWTQRDLIEMSSNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDSPGNSCPCPGPAPAKSCIMEASTDFLPGLNFSNCSRWALEKALLDGMGSCLFEWPPSRAPMSSLCGNMFVDPGEQCDCGFPDECTDPCCDYFTCQLRPGAQCASDGPCCQNCKLQPAGWQCRLPTDDCDLPEFCLGDSSQCPPDIRLGDGEPCASGEAVCMHGRCASYTRQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRSPSGSYMPCNLRDAICGQLQCQWGRNQPLLGSVQDQLSEVLEANGTQLNCSWVDLDLGNDVAQPLLALPGTACGPGLVCIGHRCQPVDLLGAQECRSKCHGHGVCDSSRHCHCDEGWAPPDCMTQLRATSSLTTGLLLSLLLLLVLVLLGASYWYRARLHQRLCQLKGSSCQYRAAQSGPPERPGPPQRAQQMPGTKQANVSFPVPPSRPLPPNPVPKKLQAELADRSNPPTRPLPADPVVWRPKPQGPTKPPPPRKPLPANPQGRPPLGDLPGPGDGSLQLVVPSRPAPPPPAASSLYL
The following text describes a protein:
Function:
Important for breakdown of endosperm starch during germination.
Sequence:
MQVPIEHNGGEQTLLVPFRAHRPPRPLLQLGSRASPVSGFQLGVVEGEWRVVQPAYGQARWTTSPPPASPTSGSLRRPTLSASKATCWGGCTIWTRPIIEAFHGKGVQVIADIVINHRTAEHKDSRGIYCRLPPRLGPAHDLPRRPLRRRHRKPGHRRRTSTTSTSASSGSSSAGSTGSRWTSASTRGASTSPRATPPTWQRSTSMPPSRASPWPRYGRRWRTAGTASRTTTRTRTGRSWSTGSIVSAAPTAMPRRSTSPPRASSTSPWRAIELWRLRGEDGKAPGMIGWWPAKATTFVDNHDTGNPCIFYDHFFDWGLKDEIERLVSIRNRQGIHPARGRCCWLLPS
The following text describes a protein:
Function:
Involved in the intranuclear transport of ribosomal precursors.
Miscellaneous:
MISCELLANEOUS: Present with 29000 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKVSKSTKKFQSKHLKHTLDQRRKEKIQKKRIQGRRGNKTDQEKADAAGTREQQQLKKSAKEEVFKDMSVETFFEKGIEIPKENKKLKKKTTKEQSDEDSSSSEEEEDMGQSMAKLAEKDPEFYKYLEENDKDLLDFAGTNPLDGIDSQDEGEDAERNSNIEEKSEQMELEKEKIELSLKLVRKWKKQLHDSPSLKLLRNIISAFKVAVNLNKEENIEDYKYAITDEKAFHELMFMVLKDVPQAIQKMAPYKIVKGARTLPNGGNVSRVSSIVKSHAGSLLILLNDITNTETAALVLHSVNELMPYLLSYRRILKELIKSIVGVWSTTRELETQIASFAFLINTTKEFKKSMLETTLKTTYSTFIKSCRKTNMRSMPLINFQKNSAAELFGIDEVLGYQVGFEYIRQLAIHLRNTMNATTKKSSKINSAEAYKIVYNWQFCHSLDFWSRVLSFACQPEKENGSESPLRQLIYPLVQVTLGVIRLIPTPQFFPLRFYLIKSLIRLSQNSGVFIPIYPLLSEILTSTAFTKAPKKSPNLAAFDFEHNIKCTQAYLNTKIYQEGLSEQFVDLLGDYFALYCKNIAFPELVTPVIISLRRYIKTSTNVKLNKRLSTVVEKLNQNSTFIQEKRSDVEFGPTNKSEVSRFLNDVAWNKTPLGSYVAVQREVKEEKARLMRESMEEQDKERETEEAKLLNSLESDDDNEDVEMSDA
The following text describes a protein:
Function:
Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP. Plays a crucial role during embryogenesis.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
MLNLAALLWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRDRNLLQVQDREQPIPWKVQFNLGNSSRPSNQCRNSVQGKHLLTDELGYVCERKDLLANGCCDVSVPSTKQYCCDGCLANGCCEAYEYCVSCCLQPSKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA
The following text describes a protein:
Function:
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
Sequence:
MANDSGISVITKIVESEQKNQILHDSILNKMPCYDKYEEINILSVEEVGLLKKFHDFSKKEKYEYFKENDTIVSILFNCLQTDFNLHLMQYVLTIFYEIIRNDGSSYSYILGILHDKDMYGYLMKLCTHSDTYIADKSSFLLSGSFCYNNNYFTEVQIKEFIIKIDFFNVSEEGKMDIYINILKIDNFRKDIYELEQFTSIIKKNLELSNNNANKQYKSVFCVWLLTFKDYFIKQLYKNNIIAIVINLFKKCRVEKILRVSLNIIKNIMHIDDCFEIIVDNNIIQTMTVLQYDKWRDNDIYDTIVQLLNKLDQRIKNYSNFERYCHELSNGKLKWSVLHTEKFWLENVMQFEKDEFKAIQQLADIIKLYAHNIIQKSETGESKEEIDAVTVAVACFDIGEFARLYPNGKKICQKFKIKENIMILIATKDRDIVREALLCAQKIMLNNWQSISNSK
The following text describes a protein:
Function:
Required to maintain the structure of the rachis, the central cytoplasmic core of the syncytial adult gonad. Failure to maintain the rachis leads to premature dissociation of oocytes and thereby impedes oogenesis.
Sequence:
MYRRENINFSHPPQLKSPPPMSSPLDSNRSYRWTSLTAANNSKFADTPVKETPQKPDMSWWSPSRGDTWRLNAPRGRTLDLVAAFDQCSRQDQLDSPRYANLGRYRRNSEPMQDNEKEVVTTNFIDDSMIEDHEEYEEHDIELGTDFYDPHMIRHHRSSERFEQSLGTGQQIETIHISTRLVPQLKRVPNSDYANDGRGDMKEYGSISKKNETPILDGTPKRPSPLTTRNIHKVDINRMDHLMKTENTVAGFITLTPQVSKVTHKSDFSKHFGQEESVRASPMSRRNRRGTQTIVLPSFDSPASVRKSIPSPGLPTKTDIRSPSSLVKSIANDFEKADFGFHRKIDAAEEIAQLRKRADNSTFDENQNMVSDSAEDNVSNDFVPRISHLEMHPSVHMGISGYAKKNHVPYGESNEEVLYSLPIKKQSRNVDREGMDQTDEILLTPRAITMRQSLPFSDIPEERTCDKIDEMFDFVEVPTGDYDDKTTLERTVDGYAEVKSQKSPNKMIRNRLDLSTNTYQEIEFEKDTTPYMQEFEEDGTGYSASSSGPQFTRSPTLVTPHAGQSVAEYRVSDKEGCAKTEKVVVQKMSQPSALATSTPKGTFAWRNKNQSNAADDSFVSSISNFSAADKINDSKRQISKLIETIEKTRKHIQLAEISLIDAKRAQMVVQELASQRVLLICRERLKLQLDEVRRLQALSVVRHPPPPINRHFKSAMVISNIAIHLNKNFNCRGSFAFIVALKCRTEIEATGVVTLLAHYQTRMHVIHFGEHMHFSNLPVDFVIAMEVYMMRVPEYKAPEKTCAAVLAAKFRNLLVPNSAHRRARNNSVLSNRTVLSMPGYQAPDCDFRFCGKLTLDRDSAGDRQFYLDDVTYPLEGTVKLQSHCSSLPEAIDVEYRGFLYLFDERSPNGEAAWDRYWAMLHRGIIFFWKNPIDEKNQKVPLSQIDLTKCTNQSVEETRNGRDHEFHIELLIDQTPSLLEKRRVVLAAESSDHLASWLNAINDTLFVLRS
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MINVMHSVVNQLEKSLNPQLWHACAGGMAQTPPLNSGVYYFPQGHAEHAAGNLDSGEFSKIPPLVLCRVLSVKYLADAESDEVFAKIKLVPLGANDEFDSNFDKSGVNEVSISKSNSFAKTLTQSDANNGGGFSVPRHIYRGTPRRHLLTTGWSNFVSRKRLVAGDSVVFLRAENGELCIGVRRAKTGLGVGAEVAAYGWNSGGRDFLGVGERGESVIEAVDLASCGRPFEVVYYPRASTPEFVVRASVVRDAMRVRWCGGMRFKMAFETEDSSRISWFMGTISSVRVDDPIRWPNSPWRLLQVAWDEPDLLQNVKRVSPWLVELVSNIPAIHLSPLSVPRKRPRLPELSGYPVSMPTFFSNNPLSPLCCFSDNNISYSGIQGARHARILLPSSNFHYNKPQPFDFKPLVDYTSPSQKTENFEESNEAKKSPLFLLFGQPILTEEQIIASNLSDENRENVGDVSNGSVSGVIQNFPLEASSDGEFSRFEEQKLELGVETTHCKVFTEPEDVGRTLDLSILTSYEELYGKSESVFCMERSETSNNVVCSDSSGTTKHTGDECRVD
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MTNAPENSAEDSLIARYFKPLATDPGAFGLVDDAAVLSSSGDDIVVTTDAVIEGVHYLATDPPDTIARKALRVNLSDLAAKGAVPAGFVLTLALRSKEDAWLGPFADALGEDAKTFACPLLGGDTVSTPGPQMISITAFGRVPRGRMVGRTGARPGDRILVTGTIGDAALGLDVLTGGAAAAALASDPAAREALVSRYRIPQPRNVLARAVRDHASAAMDVSDGLAGDLTKLCAASGVSASVDVANVPLSAAAAGLIVRNAVCVETLLAGGDDYEVLCTVPPAQSDALIAAGRAAGVAVTAIGMIVAGSARPRFLDGQGQELALKRLSYSHF
The following text describes a protein:
Function:
May play a role in plant defense against pathogens.
Subcellular Localization:
Endoplasmic reticulum. Secreted.
Sequence:
MKMCNGSSFLASLPLLLLLLSFILASFFDTAVGQIGVCYGRNGNNLRPASEVVALYQQRNIRRMRLYDPNQETLNALRGSNIELVLDVPNPDLQRLASSQAEADTWVRNNVRNYANVTFRYISVGNEVQPSDQAASFVLPAMQNIERAVSSLGIKVSTAIDTRGISGFPPSSGTFTPEFRSFIAPVISFLSSKQSPLLVNNYPYFSYTGNMRDIRLDYTLFTAPSTVVNDGQNQYRNLFHAILDTVYASLEKAGGGSLEIVVSESGWPTAGGAATGVDNARTYVNNLIQTVKNGSPRRPGRATETYIFAMFDENSKQGPETEKFWGLFLPNLQPKYVVNFN
The following text describes a protein:
Function:
Dynamin-related GTPase probably involved in membrane remodeling. Lipid and nucleotide-binding are thought to induce a large intramolecular rearrangement, leading to assembly on lipid bilayers and possible membrane curving. In the presence of the non-hydrolyzable GTP analog GMP-PNP self-assembles on a lipid bilayer; this does not stimulate subsequent GTPase activity. Does not bind lipids in the presence of GDP; perhaps GTP hydrolysis disrupts membrane-binding.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Note=Probably inserts into the outer leaflet of the membrane only (Probable). Forms foci localized in the cell periphery, and occasionally in the cell interior.
Domain:
The GTPase domain dimerizes and forms the BDLP tube surface, the middle and GED domains are elongated and involved in self-assembly, while the paddle region inserts into the outer leaflet of the membrane, possibly promoting membrane curvature.
Sequence:
MVNQVATDRFIQDLERVAQVRSEMSVCLNKLAETINKAELAGDSSSGKLSLERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDFQNFKYKYTIDPAEAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDTEARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIKGRGLTVFFLVNAWDQVRESLIDPDDVEELQASENRLRQVFNANLAEYCTVEGQNIYDERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQDVNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQPELNLFDFLSSGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQYGASYNQITDQITEKLTGKDVKVHTTTTAEEDNSPGWAKWAMGLLSLSKGNLAGFALAGAGFDWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLGVGFLQADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYS
The following text describes a protein:
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
PFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDAVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAPPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEKEATEKEATEKEAEIVEADKEKELRNHQPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQTPDPNTIVHIPVMLTGPPGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVHTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAAGPGLAPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDHWC
The following text describes a protein:
Function:
Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance.
Miscellaneous:
MISCELLANEOUS: Present with 19600 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MQQDDDFQNFVATLESFKDLKSGISGSRIKKLTTYALDHIDIESKIISLIIDYSRLCPDSHKLGSLYIIDSIGRAYLDETRSNSNSSSNKPGTCAHAINTLGEVIQELLSDAIAKSNQDHKEKIRMLLDIWDRSGLFQKSYLNAIRSKCFAMDISNNTANTASQQLSLDPKQRSKQILSNLKKSPPLNLNISLPTDLTSTDPAKQQAALFQVIAALQKHFKTLPSHTSVGTVAPPQAHTITEYGSRRERERERERYNSRRNRSRSPPAPFSQPSTGRKDRYPSVAQDQYSIGAPNTTFGTNNHHLYPDELNVSNNPHYRPKPVSYDSTLPPDHIKVYSRTLFIGGVPLNMKEWDLANVLKPFAEVQSVILNNSRKHAFVKVYSRHEAENVLQNFNKDGALPLRTRWGVGFGPRDCCDYQHGYSIIPMHRLTDADKKWSVSAQWGGTSGQPLVTGIVFEEPDIIVGEGVSSKAISQKMPTDSGRNGPRSGKPNKSGSISSISPVPYGNAPLASPPPQQYVQPMMQQPYGYAPNQPLPSQGPAAAAPPVPQQQFDPTAQLNSLMNMLNQQQQQQQQS
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRSPCCEKAHTNKGAWTKEEDDRLIAYIRAHGEGCWRSLPKSAGLLRCGKSCRLRWINYLRPDLKRGNFTEEEDELIIKLHSLLGNKWSLIAGRLPGRTDNEIKNYWNTHIRRKLLSRGIDPTTHRPINHDPAIIINNNISFSGTASSKDEDRKNMSGGGGGGGGLIVGKEEKMISSPVNIITKERCPDLNLELRISPPTYQEPILMMMKSDSDEDVSSTVCFACSTVPQKSKECGCGNSVIITGSSSNSGYDFLGLKTAVLDYRSLEMK
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MAPKVLKIKNSVADSGDSGSSEENTGENEAGTSLNISMDRVNIGSKKKLLVIPLRGIFVHRAHRLWPETIPRNCRPDFRYKNLLVYKRPYCVDFLKFCFERFHVGLWSSFKEQNLQGILDNVIGDLKNKLLFTWDQEQCTDSGFMCLEKQDKPLLLKELSHIWDKKYPNLPWSDGEYSASNTLLITYPEKAILNPLYTAIFPPSYDPESKKDDLLGPNGELRVFLAGLAEAEDVPTYVEDHPIGDPEIMPSHPDWDHYCKIICCINKKRLGCCISSV
The following text describes a protein:
Function:
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MWSMGLIRRTAMSNAIRASSQRTWLGHGGLRSCVTVKTPSEDEEEKKKEITIAEAKKLMRLVNVEDMKKKLVGVADRDVVSYSTLLEASQGMGIARSPDEAHVFARVLDDAGVVLIFRDKVYLHPDKVVDLIRRAMPLDQNPEEDQIKEEFNKLRIMKEEIDVLAHRQVRKILWCGLATSMVQIGLFFRLTFWEFSWDVMEPITFFATATGIIVGYAYFLMTSRDPTYQDFMKRLFLSRQRKLLKSHKFDCERFKELERLFKMTSSCHAAASIRNRVGLELDLEDALQSRRD
The following text describes a protein:
Function:
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRVGEAQETTEEFNREMFWRRLNEAAVTVSREATTLTTVFSQLPLPSPQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRGATLDIVDGMAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNDEDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRILVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMCHLTVRINVSTGFEGIATEQMGRISLITSISSKL
The following text describes a protein:
Function:
Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGKRRVDEESDSDIDVSSTDSETELESTQQQQQQQEGATTIQETVDVDFDFFDLNPQIDFHATKNFLRQLFGDDNGEFNLSEIADLILRENSVGTSIKTEGMESDPFAILSVINLTNNLNVAVIKQLIEYILNKTKSKTEFNIILKKLLTNQNDTTRDRKFKTGLIISERFINMPVEVIPPMYKMLLQEMEKAEDAHENYEFDYFLIISRVYQLVDPVEREDEDHEKESNRKKKNKNKKKKLANNEPKPIEMDYFHLEDQILESNTQFKGIFEYNNENKQETDSRRVFTEYGIDPKLSLILIDKDNLAKSVIEMEQQFPPP
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II GmuABC PTS system is involved in the transport of oligo-glucomannans such as cellobiose or mannobiose.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIB type-3 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-3 domain.
Sequence:
MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKEDMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVNQ
The following text describes a protein:
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions. Can release ethylated and propylated bases from DNA in addition to 3-methyladenine.
Sequence:
MTLDIEEKEEIVTSLTKAEIHLSGLDENWKRLVKLVGNYRPNRSMEKKEPYEELIRAVASQQLHSKAANAIFNRFKSISNNGQFPTPEEIRDMDFEIMRACGFSARKIDSLKSIAEATISGLIPTKEEAERLSNEELIERLTQIKGIGRWTVEMLLIFSLNRDDVMPADDLSIRNGYRYLHRLPKIPTKMYVLKHSEICAPFRTAAAWYLWKTSKLADYTKPVRPKKH
The following text describes a protein:
Function:
Probable transcription factor which represses gene expression in a subset of ventral nerve cord neurons. Involved in regulating programmed cell death and determining cell fate during development, acting in a partially redundant manner with lin-39 to repress the BH3 domain-encoding gene egl-1 in the VA and VB motor neurons.
Subcellular Localization:
Nucleus.
Sequence:
MTTIFGSSNAMFLNIEANKENIPPGTEFKKESFVLPEPRVNRTTDPDHENLLPSPVPRPSPAMSQLSDASFLSQDGGAVNTSADEADDDLEVTSRKEKSLGLLCQRFLIAINEETVGSSTREVHLETVARKMNVEKRRIYDIVNVMEALDAMQKTNKSYYQWQGLESLPKLMFDLQNEAVEEGLPERVLRVEQAMCSFTELSSPRGKQGFKDIVGSFVSCTSTPTTPSTSFDSVTVKMEPAGLLEKRSRVDTRDRQGRNSLAQLCRRFLMVLLSNPKNIRKVSLDVASTVLIKDPETEGFEPPSRSRCRRLYDIANVLVALGLIKKVHYLFGTKKIPLFVYCGPEPDQTGSFDVFQSVERLLSSSQNVPQTPIIKAQTDKIVQQIAGFGKRTLSEQNLTKPSGNTPKIAKIKSAAVRSSPMYMENNLFMFAEVVTAEAAAEKMRYDAFAQLSRTILGSVASINSLNAPLTSSQHPMTSRLPPLPMAPLQLPKLPEIPKPQAQKQFTFPATSRPRFNFPDYTPVQSTIRPLVSQMTFPQESSQLHNLDVKPKHLMSNILGESKKFKNNQNTFEHTTSSAFQVVKKGETRPKKVFGEIQNLQ
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVLPKNLQGNLMPSEITFLAENELITILPRYSIKKIDLIGTSIPNLRAMRRELVPLWVALILKSQDKCSIVPPKWLTVAYLKERYEDEIRKPLQFSDLPWNWLELSKILLEKAPDDLSDPVDQLRSVIQDLRETRLVKSKKGLKELNESNIQLNGLSLLEINELRPFVIPVMNKLRQLYDTTQSNTINADDQDMEDASDDEDV
The following text describes a protein:
Function:
GTPase-activating protein for Rho-type proteins.
Subcellular Localization:
Nucleus.
Sequence:
MVKMDVVRTTGFFLRSEPTTCRITTFAYSAEIIYFHAETTFLFEKIMKEGNELEKYSKIELNSEIWEDEEEEDNSGIVSQNERLMKLVNKQREIIYELHKDLEKVKKDNTSLRMRLSKYESTDSFPSSQPSRANSPQSDSYSSPYEKGKLFPKISLKSSKDVPTASAHISSSDHEKSSSVSLSALNNYNKTTDIKARSLDRLSDMTRPKLLLNTKRSHRSSEEPGASSPVTSPILKDSQKERIQALRNKAIKTYSVSTESAERIDSIRSDNLSPLSLNTSSFRRPITKPTPFNSDSNISIDPKDNNSNKQDHFAEIEDELRQQFLDIKVGRANASSPRRKSISIVKPHGISSPKHSTNNLSSKSGKFHSDFRVVSENVLLQARSETNSPIIENKEANNFLAPTSNVPAYSTPARPTESPPPPPISSSSTTPRPDDKPSLPPRGLSEDNDSLSLQKTGSSDTRRSSFSTLKIPDSDICFTRRRSDSNRTWTVIDPHHSQSFDNDILAEIPTSKLDNSSQKSPGKLSSKGLLNSFSPISPFSKSKSHNHHPSSQVEKSTSNSKGSMLPLDTLYNNKLSFRLDESLVRYLRFELMKTSLASLSPDFDCIGLQFVVGVSASSHLASQWKDEVWSFTRSIGECRSFATSFVLDIGAPPFPTLDWFTNDSSVIQNELLRRSVDTYFRYIFQTDLKLEQRIKLLEFLSSDTLREYLHDVFFLPPEHAQKEGVLLKYIENSGLVSRYFYLKDNILYFAENRNSPVLGTIHLKDAQVNRYNANLPIFSIIDPPHEFLTGENYQSAFVIQEKQTETRTGTATVHVLLARDVEDQKSWLRAILRQVPGSTSPLNASPFSVLSSDFPGSSRYRDQSSPIRFYGKADSRPVSQEAILSQDISSSPSPVLPPSENVASYADDSLVSNLTMSPKLRDSMEQVPLENHREFEISDRVSELSFDSSTGSVLEIADTRRNQDAPEKHVPVIEIQSSRPSLEKTDQSTPVELLIDSHSQNSQNEEKRSRMKFWAFPHHKAENYEQISDTNIPVIETNVMLSPSSTTSAEPLQKHIVRKSGIFGLPLNEAVNISTQFNDSGLPIVVYRCIEYLESCRAEKEEGIYRLSGSASTIKHLKEQFNEGVDYDLLSSDEEFDVHVIAGLLKLYLRNLPTNLLDTSMHKLFELLPNVPNDSAALGELCDVISKLPPENFALLDSLLHHLRRIIAFEKVNKMNIRNVCIVFSPTLNIPSDIFMMLILNYDHIFTDISRQTNGAQNESDSDVSDDNGEDNEFF
The following text describes a protein:
Function:
Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nucleus and/or cytoplasm.
Sequence:
MSAEASEAHEAQVKMEVSADQESEIAAVQQIASVGVSADADADADADADADADADADADADADADADADLDADADADADADADADAEADVDHDDKPDAEGDVEVQTDSIAADVKAASENEPAQSANAKMDESQATPQPMAESKLDDHQQQDSQLVSPQAGSSNQPPQPHKYMTVEQRKQLFEERIRIDPRDGEAWLNLIEEAQSREDMAATRALYDRFFKVFPNQARQWLAYLDLELAHSNFAQVEAIFNQCLRTTPSVDLWKFYLSYTRRVNPLAPSTGAEEDPAREQTRRVLEGAYEFALRFIGNDKDSGSIWTDYILLIKEREARGGWKEGQKMDDLRRVYQRAVSVPLTNIETIWKDYDAYENGLNKLTAKKFLAERSPAYMTARRVLRDLKAYSDPLVKPLLPRVPVWTTSALAGDAAQDPAQWQRERQQADAWIEYLKWEESNPLLLEDVAILQARVTSAYRRATMYLRFYPEVWYLASRYLVSILRVDEAATWLKNGMEACPGSFLLHFAYAELGEARKSTSDCAAVFDGLLDHVHAQIDARQAKLQQDLKTVDLEADRTKAQAATRRANEGDGDVDVDGEERERERKAGELLQIRKQELQAAAKPEIEGLKEASALVWIKYMHFLRRTEGIRPARSVFSRARKSPHCTWQVFEASALMEYHCSKDAVVATKVFELALKTFGSDEAFVVRYLDFLISMNDDSNARALFERVIGTFAPERARPIWERWAKYEYNFGDSVAIQKLESRLAETYPDEPATKRFIARSSYMDLDLVGPRDLGIRAAMAGASAADRAVEAAKDGGAEEGPRRKTMQEMKRLAAESAQDDTSGDWARPGASSSAGGAGGPPVKKFKRDSASPAPAAFNNQAVGQQVAGPRDAWNEFPESVLVFMEMLPSAQLFDGPMFKPEDIIDCIRSANVPVGGGARRGAAGYGGAGRGRYR
The following text describes a protein:
Function:
Vital role in embryonic development.
Sequence:
MSVVPLMFRDWWDELDFPMRTSRLLDQHFGQGLKRDDLMSSVWNSRPTVLRSGYLRPWHTNSLQKQESGSTLNIDSEKFEVILDVQQFSPSEITVKVADKFVIVEGKHEEKQDEHGYVSRQFSRRYQLPSDVNPDTVTSSLSSDGLLTIKAPMKALPPPQTERLVQITQTGPSSKEDNAKKVETSTA
The following text describes a protein:
Function:
Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.
Subcellular Localization:
Nucleus.
Sequence:
MAGPKRALEDAPDFHSNGKKPHGGTTVNREVCCVIVRNLPKNFNNRKIERFFHQCGEIRCVDTIMVKEKDAKIARIEFTSYNEVLAALTMSLKTVGCKEIVVEAMQGCTLWVTNFPPRYDGRELRRFFEDLGFQCLSVRLPSLRYNAGRRFAYVDLPSPQSADAAANTLNGMDLDGYNLVVKLSDPESRAQRSDAGTIEKREVLIRGLDFIKVTIEKLQGLVEPFGEVEKLIMPPSSDSADGRHNRGFAFVTYKDAAAAEAALALHNTVFEDRRLTVAMADRKPYLERQKVKQILVSRKPQPNILGLFPISDTLSKECIRSLVKEKAPFLEDNMLEDILLVSDHEGALLIFCDEKTAAKVALALHMSTYGKVILNCSDVRSLKQHSPQLAPTRNKVKSEEISSSLTRPDTTKRMTNDDFRKFLLHR