lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity.
Subcellular Localization:
Nucleus.
Sequence:
MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNAQKRQHGEGIAGSLKTVNGLLGNGQSKGLGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQDEEDVEEEDDETEDVKTATNNASSSCQSTPRKGKTHKHVHNGHVFNGSSRSSREKEPVQKHKSKEATPGKEKHSDHRADSRREQASATHPPAAPSPGSSAKGLAANHHHPPLHRSAQDLRKQVSKVNGVTRMSSLGTSATSAKKMREVRPSPSKTVKYTATVTKGTVTYTKAKRELVKETKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAACAEAPSRKAAAAPALAPAPADRALLSGPGKKDVPERSAERTRPKRATAGKSTPGRQAHGKPDGASCENRSTSQSETLHKPHETSARPEKGGGRAGWAAMDEIPVLRPSAKEFHDPLVYIESVRAQVEKYGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLRSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPKTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTEHDYNKFHPLPRFEPKNGLINGVAHRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLSDFHKCIYKGRSVSLTTFYRTARNIMNMCFSKEPAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEESKLEDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVADGKKKPRKWLQLETSERRCQICQHLCYLSMVSPAPELGPLPAARNSPRRGWERSKALALCCPLLSLSHSHMAGRSGPPSVPLLCHPLSLGPAFPPSHPLARCWASLFLLPLTRCGGPTFFPCFQFPFQLCDQSHCPRGHWNLSLVKTNVSPQQHSAVSSLPASGRGCFSGAPMAPAEGSALASLSQLVLLPLHLPTQLVRLPSFLVCSHSALQGLLTCQPVFSGLPAPPSLGLITSILPPLTLIAGQWQPEKPWLSGQLDWCSPLLCFFQLVSYLPLGQLP
The following text describes a protein:
Function:
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (By similarity). May be required for lung development (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass membrane protein. Note=Detected at growth cones in thalamus neurons (By similarity). PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus.
Sequence:
MKWKHLPLLVMISLLTLSKKHLLLAQLIPDPEDLERGNDNGTPAPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYICVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESKVADVTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTFGWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTVTNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTLTLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLESGVLQIRYAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSKNTVTLLWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETFAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTTQGVDHKQVQRELGNVVLHLHNPTILSSSSVEVHWTVDQQSQYIQGYKILYRPSGASHGESEWLVFEVRTPTKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEERPSAPPRSVTVSKNDGNGTAILVTWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGPGVKSEPQFIQLDSHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLSSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPATQPWLADTWPNTGNSHNDCSINCCTASNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQANLINNMNNGGGDSSEKHWKPPGQQKQEVAPIQYNIMEQNKLNKDYRANDTILPTIPYNHSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKAPKQGGMNWADLLPPPPAHPPPHSNSEEYSMSVDESYDQEMPCPVPPARMYLQQDELEEEEAERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEDLGHMPHPPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVIQKARPTKKQKHQPGHLRREAYTDDLPPPPVPPPAIKSPSVQSKAQLEARPIMGPKLASIEARADRSSDRKGGSYKGREALDGRQVTDLRTSPGDPREAQEQPNEGKARGTKTAKRDLPPAKTHLIPEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNMAEMQVLGGFERGDENNEELEETES
The following text describes a protein:
Function:
Binds to the tail domain of the KRP85/KRP95 heterodimer to form a heterotrimeric kinesin-II complex and may regulate the spindle vesicle targeting of this complex.
Sequence:
MQAEDARYLKRKVKGGSIDVHPTEKALVVNYELEATILGEMGDPMLGERKECQKIIRLRSLNSTTDIAALAREVVEKCKLIHPSKLPEVEQLLYYLQNRKETTQKAGAKKGELTGKLKDPPPYEGTELNEVANINDIEDYIELLYEDNPEKVRGTALILQLARNPDNLEELQSNETVLGALARVLREEWKHSVELATNIVYIFFCFSSFSQFHSIVAHFKIGALVMGVVEHELKKHLSWNEELLKKKKTAEENPASKRDFEKSTKKYHGLLKKQEQLLRVSFYLLLNLSEDPKVELKMKNKNIIRLLIKTLERDNAELLILVVSFLKKLGIYVENKNEMAEQQIIERLAKLVPCDHEDLLNITLRLLLNLSFDTDLRGKMIKLGMLPKFVELLANDNHRLVVLCVLYHVSQDDKAKSMFTYTDCIPMIMKMMLESPTERLEIELVALGINLACNKHNAQLICEGNGLRLLMRRALKFRDPLLLKMIRNISQHDGPSKAQFIEYISDVARIIKESNDEELVVEALGIMANLTIPDLDYEMIINEFGLVPWIKEKLEPGAAEDDLVLEVVMLVGTVATDDSCAAMLAKSGIIQSLIELLNAKQEDDEIVCQIVYVFYQMVFHEATREVIIKLTQAPAYLIDLMHDKNSEIRKVCDNTLDIISEFDEEWARKIKLEKFRWHNSQWLEMVESQQIDDGEGGLMYGDESYSPYIQESDILDRPDLFYGQTGYEDGEMYDGQVTPEYVDEYGNVQNGEYLGRPASAMYGNRYQSEYESLRPGSRVAYLTEDGQPLDEYGNPIEVYAESVDQYGRPVTPTYQYGSQAQQGPGYPY
The following text describes a protein:
Function:
Modulates cilium assembly.
Subcellular Localization:
Cell projection, cilium. Note=Localizes to the ciliary transitional zone in head and tail neurons.
Sequence:
MDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSNWILRIRQDESTPTGLTSKRSPNYLPLLNGNSNNLVSKNFSLQGGNHGNNNNNGNGINRNFLPTIS
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate-mannose synthase complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MASQLIIYSAHVVLLVLVWLLAYTEVVPVLSYIPECAHCLVYYIYAAFNVIYGVATFNDCAEAKVELLQEIKQARAELKQKRIID
The following text describes a protein:
Function:
Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton.
Sequence:
VALRVRPINATELNVLGSSEIIHCLDENLVVLRDPNEDTDDILRVNRSREKQYVFDHAFGPTASQVEVFSKTTKPLIDGVVSGYNATVFAYGATGAGKTYTMLGTDSEIGIMGLTLNNLFSQMDETNDDMAYKVTMSYLEIYNEMIRDLLNPSSGYLELREDGKGVNVAGISEVEAKTTSEVLGMLHMGNKQRTSEPTAANKTSSRSHAILQVTVTQESRVKNIIREMRVGKLFMIDLAGSERAAQTKNRGKRMIEGAHINRSLLALGNCINALSENRGHYVNYRDSKLTRLLKDSLGGNCHTVMIAHVSPASRMFEESRNTLLYADRAKSIKTKVKRNQFNVSYHIAQYTNIIADLRKEIFRLKTKIADQDINELTEGKAASKRSTYSYPTFFLIDKDHAEMTKLRSELVSTFREQMEIRRKLMDLEDTAMQIALDTNRYMLTIDE
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MFLLYEYDIFWTFLIISIFIPILAFLISGILAPIRKGPEKLSSYESGIEPMGDAWLQFQIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSVFIEAFIFVLILIVGLVYAWRKGALEWS
The following text describes a protein:
Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAPAFLLLLLLLLLWPQGCVSGPSADSVYTKVRLLEGETLSVQCSYKGYKSRMDGKVWCKVRKKKCELGFARVWVKGPRYLLQDDAQAKVVNITMVALRLQDSGRYWCMRNTSGTLYPLMGIQLDVSPAPKTERNTPFTHLANILKSGTVTTGQAPTSGPDAPFTTGVTMFTPGLLTLPRLLASTRPASKRGCSFTATSTTSQGPRRTTGSQTVTTSPSNARDSSAGPESISTKSGHLSTRSPTTGLCLTSRSLLNRLPSIPSIRHQEVYSTVLVVLTLLVLMLIMVYGFWKKRYMASYSMCSDPSRGDPPRRPEPHVEVCLI
The following text describes a protein:
Function:
Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover. Regulates the release of fatty acids from lipid droplets.
Miscellaneous:
MISCELLANEOUS: Present with 15361 molecules/cell in log phase SD medium.
Subcellular Localization:
Lipid droplet. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MFKRFSKKKEAPEDPKNLINIDKPIKELPASIAIPKEKPLTGEQQKMYDEVLKHFSNPDLKVYTSEKNKSEDDLKPLEEEEKAWLTRECFLRYLRATKWVLKDCIDRITMTLAWRREFGISHLGEEHGDKITADLVAVENESGKQVILGYENDARPILYLKPGRQNTKTSHRQVQHLVFMLERVIDFMPAGQDSLALLIDFKDYPDVPKVPGNSKIPPIGVGKEVLHILQTHYPERLGKALLTNIPWLAWTFLKLIHPFIDPLTREKLVFDEPFVKYVPKNELDSLYGGDLKFKYNHDVYWPALVETAREKRDHYFKRFQSFGGIVGLSEVDLRGTHEKLLYPVKSESSTV
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MMTDNRNTILAVILSGLVLIAWQYFYNVPAMEKQRAQQQAQAELQKTTPQPTASATPGATPQSGGAAQPSTPAAGQQAQPVVARDAAIAASPRVKIDTPRIAGSISLKGGRIDDVALVQYRETVDPKSPPIVLYSPSGTAEPYYAEFGWVPATGVTAKLPDAQTLWQQDGSGSLTPTTPAVLKWDNGEGLTFRRTISVDDHYLFTIKDEVSNVGNAPVTLYPFALISRHGTPQVSGYYILHEGLIGYLDGLQEYAYKKIDEAKSVNFKATNGWLGMTDKYWASALLPDTSAQLQARFSSNPVGNVHTYQTDYLLDPVTVAIGGSATANARLFAGAKEAGVVGINFPLAGHGGYNKELNLNHFDLLIDWGWFYFITKPMFLGLDFFYRFFGNFGISILLVTVIVKLLFFPLANKSYASMAKMKSIQPQLQALKERYPDDKVKQQQEMMEIYRKEKINPVAGCLPVVIQIPVFFSLYKVLFVTIEMRQAPFYGWIKDLSAPDPTNLFNLFGLIPLDPTTIPVFGHYLALGIWPIIMGITMWFQMKLNPTPPDPTQQMIFNWMPLIFTFMLAGFPAGLVIYWAWNNTLSVLQQSFIMRRNGVKVELFDNLKATFARKAT
The following text describes a protein:
Function:
Probable helicase that may regulate RNA molecules involved in nucleolar organization and pollen tube guidance.
Subcellular Localization:
Nucleus.
Sequence:
MAIDNGKLQEEEASSVTRFYNIILGWDYKQLTKENERKNRKDSKEKLNVVKNTYKDVDDYFETFEPLLFEEVKAQILQNKDGEEASVCKMRLVMECNEGEGFHFLLVTYEHEEDEYLAQNDLLLLSKEEVKGNSFPSSYGFAVVEHRQNNLLRLRMYLAEDIVQITKNTKSSRTKSFIQALSNMRSLITSSASPIDKRVFSLKLCGLSTIIREYIALRSVSSLPFKDLIFTAAEKSCGFGDEAWKISGPLNEFFNENLNKSQKEAIDVGLSRKSFVLIQGPPGTGKTQTILSILGAIMHATPARVQSKGTDHEVKRGIQMTIQEKYNHWGRASPWILGVNPRDAIMPEDGDDGFFPTSGNELKPEVVNASRKYRLRVLVCAPSNSALDEIVLRLLSSGLRDENAQTYTPKIVRIGLKAHHSVASVSLDHLVAQKRGSAIDKPKQGTTGTDIDSIRTAILEEAAIVFATLSFSGSALLAKSNRGFDVVIIDEAAQAVEPATLIPLATRCKQVFLVGDPKQLPATVISTVAQDSGYGTSMFERLQKAGYPVKMLKTQYRMHPEIRSFPSKQFYEGALEDGSDIEAQTTRDWHKYRCFGPFCFFDIHEGKESQHPGATGSRVNLDEVEFVLLIYHRLVTMYPELKSSSQLAIISPYNYQVKTFKDRFKEMFGTEAEKVVDINTVDGFQGREKDVAIFSCVRANENGQIGFLSNSRRMNVGITRAKSSVLVVGSAATLKSDPLWKNLIESAEQRNRLFKVSKPLNNFFSEENLETMKLTEDMEIPDAPLYEDESLPVAPYGGDDDFGDGDADQDDVAMAGED
The following text describes a protein:
Function:
Chaperone involved in RuBisCO assembly process.
Subcellular Localization:
Plastid, chloroplast stroma.
Sequence:
MVSAWFVVGSPVMDSSSSPCLCLDAHTTGTIRRKKILGKARNLELGSSFTGSRIVFRLSPKRVSRIANRKSKKLLIVNEDVAGNYDDTFGDVQKQIVNYFTYKAVRTVLHQLYEMNPPQYTWFYNHIITNRPTDGKRFLRALGKESQELAERVMITRLHLYGKWIKKCDHGKIYQEISDENLALMRERLMETVIWPSDDTNSR
The following text describes a protein:
Function:
Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Membrane; Peripheral membrane protein. Cell projection, podosome. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments. Localized to the myotube podosome cortex that surrounds the core (By similarity).
Domain:
The PH domain mediates the binding to phosphoinositides.
Sequence:
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
The following text describes a protein:
Function:
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots; Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSVSEIFIELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGSGFQDIPKKCLKAREHFDTVKTQLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDRERGFHLDIEDYLSGVLILASELSRLSVNSVTAGDYARPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKEAAAACAEK
The following text describes a protein:
Function:
Fumigaclavine A dimethylallyltransferase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. EasL also shows tryptophan aminopeptidase activity with preference for linear peptides containing a tryptophanyl moiety at the N-terminus. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde. EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline. EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine. Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A. Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus.
Sequence:
MTKTDAQGRHPQETATHAATTDEEVQDQWRAPFEVLSRTLVFQHEDHRLWWERAASKLATYLRLAKYSVGSQYQHLLMFYSVYAPNLGPWPNDKRDNVHWVCGICPGGENLEISMNYQQGAKCTVRIAAETITPAAGTDKDPFNLTAEKKMIEDLKALQPNLNFTWFNHFQREVLVPEEVALNNDEIISKVPFKNQRLHGLDLSEGAFMLKSYFMPAIRSAITGVENTQIMFESIRKLNLKNANFISALSTLEDWMVPTNGRFMEYWDGISYDAVDACKARIKIYTGIRMKSIEHARDVWTLGGRLQGEDIEKGFDLVARLWRRLMDEEPSTCEMKYWMQWVWELRTDVPFPVPKLYFSVAAAEDHYVSDTVVEILDYLGWDDLVQTHRALMDEAWSLGQTTKSYLAFSYISVTFHSIKGPYITTYGNPSGPRPVF
The following text describes a protein:
Function:
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Sequence:
MPSAQKTVLFLSATLATLFMSLADPVPVFSSMGELSEISGDEVQDVDVKSLLGDRQKWHLMARDLYKDVKTLRDEQFERDFREMVNMTAFEGVRISTPLLKPSDRCLSKNFSTERCLTRIYSVLTWYKDNWNYIEKENLTSVLVNDIKHSTKRLLEAINSQLQVRDGEMDQTSSTSLSFKSAWTRKTTVHSILFNFSSVMIDACRAINYMSRRKRGKDPKRTGDWGSADKN
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Sequence:
MTNAHTLKLKDIAGKDPGVIRVLDQGFIQLVDYMPSDYPFGQVVEGATAGDIAIVAAARVSYGTVTKGTDADRKLIEFLLRHGHTSPLEMVEFKFIVKAPVVMWWQHVRHRIQEMNFQSGRYTPYPENEFYLPEKLRAQDKVNKQGSVLVDFLSSDEERALLEELRAHYEAGFSLYKKMLAKGVAKEMARLALPGWALYHTAYVKMNAHALMHYLAKRTEPDAQYEIRVYAQAMERIFAEKLPWVHDTWRNSRGAAM
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Sequence:
MSVTETVSLDVLSLTNDARSTYGLRQQDYQRYREYCARRIRRVRKNTDMIQGKKRYEKKPVTPTSLVDPRSLQILLFEAERSWAYAMQLKADSQYEPRKKHHSIKRLCRAVSSANQLHELCQLESIDHQTSLETQAYALRLAAYVHFERQEWQSALDVFASSRSIYDKLAHVAVTASHATLCQAAMDEIDPNIRYCAYNLKFKGNQTDDIESLLELRKTSGGPGNDLLSAKIDLLVTERMHVKARAIHTMEWHGYSMDIHNEDLMAMIMEMQEISAKINGEVQGNGIVVDGRVDESQFAGIMAEYDKLLGLGWDAAKLSERDIKEDLVAVMKVKSSKSDMHSAMLKLIKEYVTYTRLEHTFDRDILLEQATSMRLKNLVHSSGSVEKRPSQRREELIQLDITMLQVVNEMKELDIIETDLALGHLVSSKGFFVVAQRLAHTADIYTADQKYAEALVLLNKAMEQVHLSRTSVVEFKRKIIKHDQQMAVNMTKLLDVLSQSICNRSLITKAKVYFENDDKVPYVSLSKTVQDMSIGTHKINQMGVGRAEHMKVFFQPSEGVIPVVQSIPPAFEPVSFKPMFYDLAYLGMEFPLWNISELAQGRSRMDRITQEIEGVNAVQTEDVYMESTRSDAENKSDSPYNSSEATGQGLLGMLGGLWGGRK
The following text describes a protein:
Function:
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly-polypeptide.
Miscellaneous:
MISCELLANEOUS: The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the substrate-binding cleft: the two negatively charged residues Glu-399 and Glu-430 that are blocking position P4 limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus.
Subcellular Localization:
Cytoplasm.
Sequence:
MFNRFRLVHKQLRLYKNFGLLGQKASVGLTLPIISLSRPYMAYMGTERSVVMITAPATKEFAESSERSNSSKKTTNKEQSDKSAESRMATSGIVESFPTGALVPKAETGVLNFLQKYPEYDGRDVTIAIFDSGVDPRATGLETLCDGKTVKVIERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMALNTDPEKAVRVGLKSFSDLLPSKVRNNIVAQAKLKHWDKPHKTATANASRKIVEFESQNPGEASKLPWDKKILKENLDFELEMLNSYEKVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHETRNVDDFLSISVNVHDEGNVLEVVGMSSPHGTHVSSIASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNVEKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPKDKFNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLFEIPVTVVQPHVLESDQNTPVFEPASSKGDNSVEFQPNTIQRDFILVPERATWAELRMRITDPNRGEDIGKFFVHTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLRFRGVEAHNPNAYVMHAGRGIHKLEIEALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRDVIPDGRQVYQNLLAFNLNVAKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAHSHTSFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIVGGRKYVSSPLRLSTRVLYIAPITQERLTKANLPAQCAWLSGNLVFPQDEVGRRVAQHPFTYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTNPAAGDGISVQNDPPVDSSGSPASPKKGKANADDYAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPKHLQANLLLIQNIESNQLKSQLPLTFVNAQKTSPPEAGESADKQKEDQKKVRSALERIVKLADKVIQETDSEALLSYYGLKNDTRADAAKIKTNMDKQKNTLIEALSKKGIAVAKLAVLDDCIKDSLAEINELYTEIIKFVDANDSKAIQFALWHAYAHGHYGRMYKYVVKLIEEKRTRDHFVELAAINGALGHEHIRTVINRMMITAFPSSFRLF
The following text describes a protein:
Function:
Negatively regulates expression of bdcA.
Sequence:
MVTKKQSRVPGRPRRFAPEQAISAAKVLFHQKGFDAVSVAEVTDYLGINPPSLYAAFGSKAGLFSRVLNEYVGTEAIPLADILRDDRPVGECLVEVLKEAARRYSQNGGCAGCMVLEGIHSHDPQARDIAVQYYHAAETTIYDYIARRHPQRAQCVTDFMSTVMSGLSAKAREGHSIEQLCATAAMAGEAIKTILEE
The following text describes a protein:
Function:
Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTSAFYGGDEVSAIVIDPGSKWTRIGFSGEDIPKCVLPSYCGEFSDGRRLFGEEYIYKSNPGMEIKNAIRNGWVENWDVTVDLWRYGLEQQLKTNPLEHPILITEPFDNPPENRVKTLETMFESLRCPATYLAKQETCAAFASGKGTACLVDIGAERSSVSAIYDGFVLQKGYQVQHFSGNAINDILAQTLRDKNFEVMPKYLVKSKNPVEIGQPANCELRPRDTTDSYHQFQVQRVYDEWKEECALISDVPFSSETTIAESEFEFPDGSRMMFGAERYQIPEHLFVPGSDEEMNEEPSKPIEQTENNEVSQQDSSVTNTSSRILGIPQLFQNCISECDVDIRASLLNNVIVCGGTSLMQGFSLRLQNELSKLYPGSRLKIHASGHVVERSYASWLGGSILSSLGTFHQLWISRQEYEEHGSDRLALIEKRCK