lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MAPARFRLGITVLVLILPALSNGQFWKDWLWTGSKETTASPRTNPVIPETSSVETTAVQQHSLDASPTTLHHTSDALLSAQHTSAPAEQHSSEKDNLPEATSADLETASLSTPKKPTPSAKPYTELSPTASSAAVPEASTVILSTEGKNVSTETAGVTRPLETTESTTSARSQEEKQIWNIFSVQKGKQNVVPGTVATTPTVTPVAMDVTSGPSLSEAPKPHKLESEHNIAGVGAEILNVAEGIRNFVHGWEDKVTNATKQTPTPDTEMVIATTIRSLTINDTATLSHKDTEQSENTTENHTERPVSGPHKLISSHNKPLLPGISSFPVDTVVSAPLSNSVSEVSTENVEPVSPSSLLGLGGAALIPGTADAQTLLTDHTGSMRSAIPLKVTSLSSGLSHDVLNSSQLNGNNIGKQSAYPSNQVYKSPELLKHSGIAATLHGVSAPNYYVTSLKGHPHPSETDLLTSTKSPIPSFRHNSSRTAFILPRLTPSNARCFPTPTSLSFCKRLGIDSFLLPNFLNHSTVLEIQAALHDWEGLFKSQCHQYLEWFFCLLLAPSCNTGTLAPPPVPCRQFCEVLQDACWNLLEGSHLPVSCDSLPENNSGVSCVYIHFYAGSKTQVSASSELTDGFGTEVGLLQLIGEPVPNEITKVFGPDKTPAYVFDKEANTGQVAQYHLPNPMYRDFSLLFHVQPSTNKAGILFAITDASQSIVYIGVKLSEVKDGKQDIIFYYTEPGSQDSYVAATFNVPSLVNRWSRFAISVEDEEVVLFMDCDELERVRFERSPDEMELEDGSGLFVAQAGGADPDRYQGVIADLKIVANPRAAERQCEDDSDDDDGISGDFGSGIAENDLVTTSPPVVIKVQPPITVPPIQRTPVEKEIVVTGQGQQGIKGEKGDHGEKGERGLTGPKGDSASVSPASDSNGEKGQKGEVGVKGSAGFGYPGPKGQKGDPGTMGPRGPAGPPGPSILQKSDGTTVRQVTGPPGPQGLAGPAGKDGEPGDPGEDGKTGEVGPQGFPGTPGDPGQKGEKGDTGVGMRGPPGLPGPPGPPGPAKTDKLTFIDMEGSGYSGDLEHVKGPPGLPGPPGPPGVPGLPGVPGTFGMNSTGLPGPSGLPGLPGKEGIPGPPGLPGPPGKDGLPGASGVAGIRGEDGEIGLPGAPGAKGNPGEQGQPGAAGQPGLAGLPGPMGPRGQPGPPGPPGPVSRGSAIGFDDMEASGLGFGLREGAQGLPGLPGAKGEQGNPGLPGLQGVKGDSGPPGPEGRQGLDGFPGPEGLRGEKGERGERGETGHDGVGIPGPPGPPGQVLYVPSDDKSVVGAIPGPEGRQGIAGLPGPRGPKGDQGLDGFPGTHGAKGEKGEPGLMMRPDGTLYTDPSKGEKGDQGLRGPAGSVGPYGQKGEIGFPGRPGRPGMNGMKGEKGECASSGSGLRGPPGPPGPPGPPGSVVNGDQNIPGAYPGQKGERGFPGPQGDVGPAGPPGSFPYDLSTFASVLRREAGLKGEKGESGGGAYGQGIPGPPGNPGYPGLPGAKGESVQGPPGPVGPPGPSGIGYEGRQGPPGPPGPPGLPGASSSYPGPHRQTISIPGPPGPPGPPGTSGGTSGATVLQTHQTMINLAHRLQEGTIVLVQERAELYVRVREGFRRILLGEYTTLSGPGQDNEVAAEQAPVVPYPHRNKDSDYLQSTEENSNNANVPSGARPWSDPRLPEPPRVDPPPPDHHQHGNPRPLEPSPVHTHQDFNPALHLVALNAPISGSMKSIRGVDFQCFEQARKAGLHGTFRAFLSSRLQDLYSIVRRADRQSVQIVNLRDEVLYDNWDSLFSGSEAQMRSGARILSFDGKDVTTDPTWPQKMVWHGSDAKGRRLTESYCETWRTDESAVTGQASSLTSGKLLEQRPQSCNKNFIVLCIENSFMTNNRK
The following text describes a protein:
Function:
Splits dipeptides with a prolyl residue in the C-terminal position.
Sequence:
MDHLAHYYHAHIDELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQLIFYRPVDFWHKVADVPDMFWTEHFDIKLLTKADKVAELLPTDIANWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTKTEYELECMRRANQIAVQGHQAAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLSFLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHGKVAQMLLDFDLATGDAQGLVEQGITSAFFPHGLGHMLGLQVHDVGGFAFDERGTHIPAPEAHPFLRCTRILAPNQVLTMEPGLYIIDSLLNELKQNSRGKQINWNSVDELRPFGGIRIEDNVVVHQDRNENMTRELGLA
The following text describes a protein:
Function:
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles between the cytosol and the nucleus.
Sequence:
MFRRKLQALDYHNPAGFNFKDETEFRNFLVWLEDQKIRHYKIEERGNLRNIHSSEWPAQYEKYLNDVNCPFKVQERQESIDWLLGLAVRLEYGDNAAKYQNAKPYNSDVSKSAEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLMMLKAIRILVQERLSQEAVAKSNSAKEGLPVALDKHILGFDTGDAVLNDAARILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MHGLPRKVPTAEEAAASAVKAEKLRCLQSQVLSNHHHKIYTKEAVEASAKLLETNPECYTAWNYRKLAVQHNLSQSDSDPDIVKSILDQELRVVQSALRQNFKSYGAWHHRKWVLCKGHSSIDKELKLLDKLFTIDSRNFHAWSYRRFVAQLMNRSEKDELDYTECLIGKNFSNYSAWHNRSFLLSNLVKKSVEGFSEKNEVLTREYELVRDAVFTDQDDQSGWFYHLWLLKQTVNTEGPMLVSSWPAHRSDIILLIDSCLEDCASSPFSTFQFDSGTFPLILFFNQAVEGINSSTVKVASGFNSNEDLTWKPVSTHISQAAQVWVTELSFPDVNLHSLESYPVEVSFGQYQGIVSSTGSYYSHPSHLAFTVRVQSVKTGLAEGASVARISWTDNNFHLCEPHLLESDLVASLDNLSIKSKNEPAAATWQEKIIAEEIKLFRELSDCKIGKLTLARLLSAHDALVSSDKSAHSEEVLRLYCQLIKLDPTHARYYKDVHSLALLQQVTSSQESVLSRCFHYRDVTSLSSGYPICLRLNNLSLSRIGAVEKLLWVQMLDLSCNELQSIEGLEAMQLLSYLSLSRNKLSSFTSLEPLRQLKSLKMLDISYNEIGLHSIDTTRYLCSSPLSHSVGNEWEQDKTVIYGIDMTNYWEAFFVLKGLNLTQLDVLGNAIADEKFTSFLVKVLPKLKWLDGVKLN
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSDSPAVEIDFFRLNEEASSKKLSPRKNIQDVISKINPELLKSAFANNGFVANKLSYASHPHLQTLPVYNQECSRVNTAATATPLTIIYNGVVSVFDVSPNQADNIMKLVDAVNPVSKTSVEPVAVKNENNQTPVIAGGVSKDLPLSRKKSLKRFLEKRKERKESISPYASLH
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MGEYKKEVINYSFQESSKMNDLISDSKRDKMLNGDSLEELISKKCSEDIESASEKNTSSSRKGFVLLLIGVVCLFSTVLLLLLLPLSNGCLRMRADPLPCSTCPQTLGNTNLVDGQCAVHRTCVSCTSTQVAYSRSGQCLIASVTCPNVLPSNSPRVRLLKADNTYVDIAYTSALSLSCTSGSSWTYIDGTGTPVTNIKKAICFGKMENTQESPIDLNTNTAVHTSLYNASQFKVSYGSGIIDHISVARTYGGFHAVMKANANAFFTASHLDARYRLVQYHGHWNMDTLMRGSEHTIDGIPFNAELHFVHMREDFTSFQQAVAEGGVAVIGILLHV
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity).
Subcellular Localization:
Cytoplasm. Note=Displays a punctuate distribution and localizes to a submembranal ring. Localizes to intracellular bacterial pathogens (By similarity).
Domain:
The coiled coil domains interact with the SB domain of TSG101; The PTAP motifs mediate the binding to UEV domains; The LRR domain is necessary and sufficient for localization to bacterial targets; The RING domain is required for ubiquitination.
Sequence:
MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLVTIKVLDLHENQLTALPDDMGQLTVLQVLNVERNQLTHLPRSIGNLLQLQTLNVKDNKLKELPDTLGELRSLRTLDISENEIQRLPQMLAHVRTLETLSLNALAMVYPPPEVCGAGTAAVQQFLCKESGLDYYPPSQYLLPVLEQDGAENTQDSPDGPASRFSREEAEWQNRFSDYEKRKEQKMLEKLEFERRLDLGQREHAELLQQSHSHKDEILQTVKQEQTRLEQDLSERQRCLDAERQQLQEQLKQTEQSIASRIQRLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETENLRQREIAAAMQQMLTESCKSRLIQMAYESQRQSLAQQACSSMAEMDKRFQQILSWQQMDQNKAISQILQESVMQKAAFEALQVKKDLMHRQIRNQIRLIETELLQLTQLELKRKSLDTETLQEMVSEQRWALSNLLQQLLKEKKQREEELHGILAELEAKSETKQENYWLIQYQRLLNQKPLSLKLQEEGMERRLVALLVELSAEHYLPLFAHHRISLDMLSRMSPGDLAKVGVSEAGLQHEILRRAQDLLAVPRVQPELKPLENEVLGALEPPTAPRELQESVRPSAPPAELDMPTSECVVCLEREAQMVFLTCGHVCCCQQCCQPLRTCPLCRQEISQRLRIYHSS
The following text describes a protein:
Function:
Essential in pre-tRNA processing. Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.
Miscellaneous:
MISCELLANEOUS: Present with 3730 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSSAEMEQLLQAKTLAMHNNPTEMLPKVLETTASMYHNGNLSKLKLPLAKFFTQLVLDVVSMDSPIANTERPFIAAQYLPLLLAMAQSTADVLVYKNIVLIMCASYPLVLDLVAKTSNQEMFDQLCMLKKFVLSHWRTAYPLRATVDDETDVEQWLAQIDQNIGVKLATIKFISEVVLSQTKSPSGNEINSSTIPDNHPVLNKPALESEAKRLLDMLLNYLIEEQYMVSSVFIGIINSLSFVIKRRPQTTIRILSGLLRFNVDAKFPLEGKSDLNYKLSKRFVERAYKNFVQFGLKNQIITKSLSSGSGSSIYSKLTKISQTLHVIGEETKSKGILNFDPSKGNSKKTLSRQDKLKYISLWKRQLSALLSTLGVSTKTPTPVSAPATGSSTENMLDQLKILQKYTLNKASHQGNTFFNNSPKPISNTYSSVYSLMNSSNSNQDVTQLPNDILIKLSTEAILQMDSTKLITGLSIVASRYTDLMNTYINSVPSSSSSKRKSDDDDDGNDNEEVGNDGPTANSKKIKMETEPLAEEPEEPEDDDRMQKMLQEEESAQEISGDANKSTSAIKEIAPPFEPDSLTQDEKLKYLSKLTKKLFELSGRQDTTRAKSSSSSSILLDDDDSSSWLHVLIRLVTRGIEAQEASDLIREELLGFFIQDFEQRVSLIIEWLNEEWFFQTSLHQDPSNYKKWSLRVLESLGPFLENKHRRFFIRLMSELPSLQSDHLEALKPICLDPARSSLGFQTLKFLIMFRPPVQDTVRDLLHQLKQEDEGLHKQCDSLLDRLK
The following text describes a protein:
Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKLSIRMLDQRTITLEMNESQEVRALKQKLGNLPEVAMPAENLQLIYSGRIMEDAMPLSEYRIAEDKIIVLMGKKKVDKSSPEEKVAPTPPLAAGPNVLRTEDVVPSLAPNDQWVSDLMSMGYGEEEVRSALRASFNHPERAIEYLINGIPQEVVSEQGLAAIPSVQTSDQLQQLMADLNITRMREMINQNPELIHRLMNRLAETDPATFEVFQRNQEELMNMISGGASRTPNEIEHLQITLTAEETAAVGRLEALGFERVMAVQAYLACDKDEQLAAEVLIRQSEEDRD
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MEQKKNNKNNGGRIKEESNTPSEVFASCSFSSLGLHPTLCDQLKERMGFDAPTLVQAQAIPVVLSGRHVLVNAATGTGKTVAYLAPIIHLLQKFDQRVQRSDGTLALVLVPTRELCMQVHEILQKLLHRFHWIVPGYIMGGENRSKEKARLRKGVSILVATPGRLLDHLKNTASFVHTNLRWIVFDEADRILELGYGKDIEDILNFLGTIKNKDADPEVRMQNLLLSATLNEKVNQLANISLENPVTIEEPGKLNSSEKEYRLPSQLVQRYIKVPCGSRLVVLLSILKHLFEREASQKVVVFFSTCDAVDFHYSLISGFLWSAMPQSEKEQRTKFLGCKTLRLHGSMNPEDRKTTFQTFKTEKSALLLSTDVSARGLDIPKVRCIIQYDSPGEATEYVHRVGRTARLGEKGDSILFLQPLEIDYLKDLEKHGVALSEYPVLKLLSSFPSYSSKNQANKFVSIEMHPWLVALQRGLESFISSEPKVNKLAKDAFSSWVRAYTAHRGELKQIFTVKKLHLGHVAKSFALKDQPSIVNKSIQKQLKRKRDDKQKIKSKKRFISKSRVVSSE
The following text describes a protein:
Function:
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
Subcellular Localization:
Membrane, coated pit. Membrane; Single-pass type I membrane protein.
Sequence:
MASCWSAKGSLAWRSAQLLLLVAAASCRGNSALAEHSENVHISGVSTACGDIPEQIKGPSGIITSPGWPLEYPVRLNCSWYIRANPGEIITISFQDFDVQGSRRCSLDALTIGAYKNMENYRVCGSSIPSPYISSQDHVWIRFHSDDSISRKGFRLAYFAGKSSETSCDCNQFHCSNGKCIPESWKCNDMDECGDNSDEEICVKAGPPTAAAFQPCGYNQFQCLSRFNVYTCIPESSKCDGNLDCLDLGDEIDCGVPTCGQLLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPRKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKDEFPCSRNGACYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSIRLPIAGRSSNIWNRIFNFARSRHSGSLALVSSDGDDIASQNTNRESERNGSHRSLFSVESDDTDTETERRDAAGAVGGVAATLPQKVPPTTAVEAPVVCGTPSVQNTSSNADHGREAASIEPPNSSPGRHQFSNALSRMTQGLRWVRFTLGRSSPANQNQSPLRQLDNGVGGGRDEDDDVEMLIPVSDVASDLDVNDCSRPLLDLTSDQGQGLRQPYSSSHNGVRSCNRDGPCERCGIVHTAQIPDTCLEATLKNETSDDEALLLC
The following text describes a protein:
Function:
Involved in the establishment and dorsoventral patterning of germ layers in the embryo.
Subcellular Localization:
Nucleus.
Sequence:
MMSARSVSPKVLLDISYKPTLPNIMELQNNVIKLIQVEQQAYMQSGYQLQHQQQHLHSHQHHQQHHQQQHAQYAPLPSEYAAYGITELEDTDYNIPSNEVLSTSSNQSAQSTSLELNNNNTSSNTNSSGNNPSGFDGQASSGSSWNEHGKRARSSGDYDCQTGGSLVMQPEHKKLIHQQQQQQQQHQQQIYVDYLPTTVDEVASAQSCPGVQSTCTSPQSHFDFPDEELPEHKAQVFLPLYNNQQQQSQQLQQQQPHQQSHAQMHFQNAYRQSFEGYEPANSLNGSAYSSSDRDDMEYARHNALSSVSDLNGGVMSPACLADDGSAGSLLDGSDAGGKAFRKPRRRLKRKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQQIIPTLPSDKLSKIQTLKLATRYIDFLCRMLSSSDISLLKALEAQGSPSAYGSASSLLSAAANGAEADLKCLRKANGAPIIPPEKLSYLFGVWRMEGDAQHQKA
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Sequence:
MPFSRGRKQATSKLPHLRGKGPAMENALHKQEEGTQVKRSPSSPQGAPKKRSAFVDITNASKGLPTQNKKKKNEANLKKMSVANNGKKQALCSHIYSMEQLIVILTSRSGSITPEEKPEKPQEKKAIEKEAVKPQVEEQCSQIPEEFDIDKDHLQDSFMTAEYAKDIFDYLKAREEKFILQNYMDKQPDLNREMRSILVDWMVEVQENFELNHETLYLAVKLADHYLSHTVSARETLQLIGSTTMLIASKFEERCPPCVDDFLYICDDAYKREELIAMEMDVLQTLKFDINIPVAYRFLRRYAKCVQADMETLTLARYICELTLQELEFVPERASQLASACLLLALHMKDLGGWTPILQYHTGYTLADLVPLVKRLNFLLTYPTDDKLKSVRSKYSHKVFFEVAKIKTLDMMQLHEALC
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
Sequence:
MSRSTDPGHFFQTDASESTRARRAAKSGNKNGNPIVLQSKLLSLIPDPFSSQCVYIAESAGCVRRVNIETRDTKTIYRGPTAPVTSVAIGGHGGNTVFAGCWDKQIWSWDRESKVLGKKFKGHSDFVKAIVCVNIEGTDCLISGGADAKIMVWNTTTGERLHTLRDKSESMMAVQHLALDPEDSTNTEVVLVSSSSDPHIRRWRVSLSSASQILDTTEEISEQSKPIRDTILEHETSVYQVLFAGDEEETDLWTASADGTAKCLSRAKHWSAEETYEHGDYVRTVAVTDTWVVTAGRDEDVKVWDKATGKLWHVYDGHYEEVTGLTVLQGGKQAISISIDGTVRTWGLGKVELEKARLENEEKAKGIVKEEKVEPKKGLMTAEEEAELAELLDSDDD
The following text describes a protein:
Function:
Endonuclease that cooperates with the MRX complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of SPO11 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for proper recovery from checkpoint-mediated cell cycle arrest after DNA damage. MRX complex and SAE2 remove a small oligonucleotide(s) from the DNA ends to form an early intermediate which is rapidly processed by EXO1 and/or SGS1 to generate extensive tracts of single-stranded DNA that serve as substrate for RAD51. Plays a transitional role in the dissociation of MRE11 from, and the recruitment of RAD52 to, repair foci. Ensures that both ends of a DSB participate in a recombination event and impairs the formation of palindromic structures in the genome. With TEL1, promotes microhomology-mediated end joining (MMEJ) but inhibits non-homologous end joining (NHEJ), likely by regulating MRE11-dependent ssDNA accumulation at DNA break. SAE2 and MRX are particularly important for removal of hairpins, bulky adducts and other irregular end structures. Facilitates telomere length reequilibration and subsequent checkpoint switch off. Involved in homing efficiency of VMA1 intein VDE and in repair of transposon excision sites.
Miscellaneous:
MISCELLANEOUS: Present with 1030 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Accumulates in foci at the precise time when MRE11 foci disassemble and RAD52 foci assemble. Remains associated with DSBs along with MRE11 in nuclease-deficient cells.
Sequence:
MVTGEENVYLKSSLSILKELSLDELLNVQYDVTTLIAKRVQALQNRNKCVLEEPNSKLAEILCHEKNAPQQSSQTSAGPGEQDSEDFILTQFDEDIKKESAEVHYRNENKHTVQLPLVTMPPNRHKRKISEFSSPLNGLNNLSDLEDCSDTVIHEKDNDKENKTRKLLGIELENPESTSPNLYKNVKDNFLFDFNTNPLTKRAWILEDFRPNEDIAPVKRGRRKLERFYAQVGKPEDSKHRSLSVVIESQNSDYEFAFDNLRNRSKSPPGFGRLDFPSTQEGNEDKKKSQEIIRRKTKYRFLMASNNKIPPYEREYVFKREQLNQIVDDGCFFWSDKLLQIYARC
The following text describes a protein:
Function:
Component of the atg1 kinase complex that activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phase and has a role in meiosis and sporulation.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure.
Sequence:
MPRLNTQLPRMYSAPPGHSKAVSTELNKDLSSVGGRSAKLGQVIHHCFYKTGLIILESRLNVFGTSRPRESSKNNKWFNLEIVETELYAEQFKIWKNIELSPSRKIPPMVLHTYLDISDLSKNQTLSVSDGTHSHAINFNNMSTMKIVLERWIVNLDGEALSTPLELAVLYKKLVVLFRSLYTYTHLMPLWKLKSKIHKLRAHGTSLKVGCALSTDDVLSNDFLPISAPISSSLGSSIATFSFSPVGTPAGDFRISVQYRKNCHFEVHDSDALLSNQLLSADKHQLAASNNSQDFEDGKQYDQPPPSFATRLAKQSDPNSLLQSEIQHLASIESITAQAAPLVTIHPFKSPSLSASPGSNFDNMSISPKVAVNRYIHRGPSATSLNKFSMISDAASKSRAKLPPLTSGSLKLNTLDISNTPNLRRFSSSFGPRERKESFSSRNRLPLVNHPIRSIFKHNVSENPITDHSEHAVYDSEFASKDDLSGFIQLLDSHAHHLNASEGSKSSGSFPGKVQTLTSGISPVAHPHNSLGSSNEIFDIDTYNHSIDNSGSRFTEAVKHNLGNSSHSIMRHHTLGTLRSRPSFSEKSTFPAPLTSISQASTFQGDNRSPSTVIPHTQTEVPSANDTSKQLASLHDMRKSQSPICARSATSAGLPRFEYHTSLSKSLEHSSTPASLQATKTPSPSFVLEPGIPQEYKKHFDNLSEERRQCLTPSTPTYEYYNEHNPNYDDDLLFTMTDMTLEPHDVSAIRLGSPKSDD
The following text describes a protein:
Function:
Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor.
Sequence:
MQWRAMEINPEMLNKVLSQLGVSGAWKFVDVLGFEDESLNNVLTPVCALLLLFPLTPQHENFRKCQIKELQEKNANNKVYFLKQTIGNSCGTVGLIHAVANNKDKFNFAENSVLKGFIEQTAALSPEERAIHLEKNEAIKSAHNSVAAEGQCRENSDVNFHFILFTAVDGHLYELDGRLPSPVEHDPTSEGTLLKDAAKICRQFTEREQGEVRFSAVALSKSA
The following text describes a protein:
Function:
Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Miscellaneous:
MISCELLANEOUS: Present with 5240 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MRFLSKRILKPVLSVIILISIAVTVVLYFLTANENYLQAVKDSAKSQYASLRESYKSITGKTESADELPDHDAEVLDSIMDRLHEPLYEKDTFDPNEVLAENKQLYEEFLLQEISEPKVDNLVRSGDPLAGKAKGTILSLVRNSDLEDIISSIQQLEEEYNKNFGYPYTFLNDEEFTDEFKDGIKSILPKDRVVEFGTIGPDNWNMPDSIDRERYDQEMDKMSKENIQYAEVESYHNMCRFYSKEFYHHPLLSKYKYVWRLEPNVNFYCKINYDVFQFMNKNDKIYGFVLNLYDSPQTIETLWTSTMDFVEEHPNYLNVNGAFAWLKDNSQNPKNYDYTQGYSTCHFWTNFEIVDLDFLRSEPYEKYMQYLEEKGGFYYERWGDAPVRSLALALFADKSSIHWFRDIGYHHTPYTNCPTCPADSDRCNGNCVPGKFTPWSDLDNQNCQATWIRHSMSEEELEMY
The following text describes a protein:
Function:
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood.
Subcellular Localization:
Cytoplasm.
Sequence:
MKQILVVDDDRHILKLVGHYLRAEGFHVLEASDGVEAEKIVETEQVHLAVIDVMMPNMDGFELCQKMRASYPDIPVIMLTAKDALADKSRGFEVGTDDYVTKPFEPEELIFRIRALLRRSNQASEVKINIGNITIDQKSYGIKIGNQERMIPVKEFELLYQLASYPGRIFTREELIERIWQRDYDGSDRTVDVHIKRLRDHFDEEKDGIRIVTVRGVGYKLEETR
The following text describes a protein:
Function:
Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins (By similarity). Involved in the degradation of several hypomodified mature tRNA species and participates in the 5'-processing or the degradation of the snoRNA precursors and rRNA processing (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, P-body.
Sequence:
MGIPKFFRWMSERYPLCSQLIENDRIPEFDNLYLDMNGILHNCTHKNDDHSSPPLPEEEMYIAIFNYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRFRTAKDAHDARLKAERNGEDFPEEQFDSNCITPGTTFMERVSRQLYYFIHKKVTNDSQWQNIEVIFSGHDCPGEGEHKIMEYIRTQKAQPSYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGPASRNRSKELAHQKFYLLHLSLLREYLEFEFQECRSTFTFKYDLEKILDDFILLAFFVGNDFLPHLPGLHINEGALALMFSIYKKVMPSAGGYINEKGVINMARLELILLELENFEKEIFKAEVSETKNNGNSDKPSFDFLKYITESTNDIKAMTGEQKNYFLQIKKFLSSREPFIDFSANISSVDQRFLRRLCNDLHLSFSKIIKVDGTHLLRITFRDLEFNDEDEDEIEQDEIERVLQKYDNIPLLNEEQALKEKNVEKDFIQWKDDYYRSKVGFSYYDEEALKAMAERYVEGLQWVLFYYYRGCQSWGWYYNYHFAPKISDVLKGLDVKIDFKMGTPFRPFEQLMAVLPARSQALVPPCFRDLMVNSESPIIDFYPENFALDQNGKTASWEAVVIIPFIDETRLIDALASKDKFLTEEERKRNSFNAPTVFSLAEDYTSFYPSSLPSLFPDLVTRCIQKPYSLPSMEGKEYLVGLCPGVFLGAFGMVGFPSFHTLKHKAELVYHGINVFGNESRNPSVIVNVEDVKSALTSEQIAMQYVGKRIFVDWPYLREAYVESAMDESYMYLASNSTIEKRDLAEIEKSQWGRKCSHKIREYSKRFGVLFGDISLLLQVRPIKGLEYTREGALVKIFNESVLEDYPAQLVVEKIAIDDPRFTEREAPPVEVEYPPGTKAFHLGEYNYGRPAQITGCKDNKLIIWLSTAPGLDAQWGRVLVNDSKSKEKYYPSYIVAKLLNIHPLLLSKITSSFLISNGTKRENIGLNLKFDARNQKVLGFSRKSTKGWEFSNKTVALVKEYINTFPQLFNILTTHATKDNLTVKDCFPKDDTQQLAAVKHWIKEKGINSLTRVSLDEDALDSDIIKLIEEKASTIDSTYQVPKKVFGVPRYALLKPSQTRGILHSQEFALGDRVVYVQDSGKVPIAAYGTVVGIMLHHLDVVFDLPFMSGTTLDGRCSPYHGMQVEVSMVLNVTNPQFVVNTRAGKNRKTNVSANNVSQGTDSRLVTKPTSTFPSPPSPPSSSVWNKREHHPKPFSLHQVPPPESLIHKSKSKFSKGNHHSTNGTQSIRGRGGKRGKPLRSKELNRKHDHIVQPMGKLQIN
The following text describes a protein:
Function:
Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MNLNNFSLIRDLAKNKHIFKFKTDNINKNILPFSTKYEPKSKFKNNESIIKVLNNNNSNSNSNSNSNSNIIRNNEKIKKQIISNKITSSSSSPLNKIQPIFSTSLISNNINKFNSLINNTNIQSQRFYCGIWGGGKNNKNNQNKNNNDSNENKNDSNNNNSSSSGSNGNKEEKNNENKQTKYSYKEGIFAFIQKLVEKVKYFLTRNKPLTSDQRIAIISWAAFGTGTLILIGTTSLVSFILFFANTFEFSEFLANKVGKYLTNNTGITITFESARGDMKTGYIRLENVNISRTPRSDDRVSSIQLSIRQIDIKLNFLWFLEGKGLIQECLVNGVRGLIDRRTEGINWNKNMVYPRRKKMSGDFEFEKLEVRDLFVTMYLPDKSYRPLPISIYHLESDRFRKQWMLLDLISCKSIVGKFDNSLFTLTIPQHHRQFNIEQEDLLSMKLKQLTSNNNQNFRNHDNYYNYITEPSDNLFLTQSNSQIDNYNSNNNNNSNFIDNNSEINNNNFGEKRLSKNKLTKKKRDEKIEYRELKIDGLNTDILSRNATGPLGWIKEGTFDIDLLILLPNHMDDNEKELLSTEQVEYGIIPPSSENPRMNLHLDFKVQLNHLYSVAPLYTPEISYISNALAHPIVAYINSHSKHIPLSFKFAMNVRQFNGSWTPSQACFWEMISASVYAELLKKVQETKNVTTLKKVASDLVNDLVQWIAPHLQAIHYQQKEKEEQEKLLLLQKELKEKHKKRISQNNNNHDETILYNENGEIISNEQENIEDNNNNNNNNNNEKLENVKENQSDNEQDEDNQEEEEEPINQQLVYYQEMQKLLDNQQQKQYY
The following text describes a protein:
Function:
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Perikaryon. Cytoplasm, perinuclear region. Note=Co-localizes with rab-2 to perinuclear puncta in the perikaryon.
Sequence:
MEEPTTSELKLSDNVMNEISDMCITEYCKPNMSLMAQINELFPTEQSLTQLDSIIASVEGEIGELDNELAYLVETNANVSERGEEALKHAQDAMIELEKSIGSIRERTKSSDEIVREMTRDIKQLDIAKRNLTASITTLHHLHILLTGVESLGAWVDKKDYSSIARQLPAILNVLQLFDAYKESDQIANLSGQLDKLKASLTIQLAKDLKNAFQTGQLSDRITDMCRVAAALEGNVKENFVKWFIEQQLSEYVIIYADNEEGAWLDKVDDRYKWFVRKLTDFERAGLSNIFPADWHMGRRLTSEFCTVTRDILYRIMTRRRQDLDWKLLGHAIQHTKMFEALLTKRFPEKDGISFEKAIWSVFDTFLDVFINAQEKTLNEFLDTCASKIRSGEEKPSRESSTHAVPFPSSADMFLLLKKVITESSKLSSEPDALIRDVIGVVRVCLRGYATSCLVAFLPSLGSQQSGAANLFSLIREEIAYPRLTPDQQFLVCCILATADWCAETSIQLQEKLSQRIPGVDISQETEAFYSITNQSLQVLVQDVESTCDAALQSISKVNWTAVDCVGDESPFIGSMRAHLRQAVPLIRDMLSDRRKYFAHFCLKLATQLAHKFVGSLFRCRTISTHGAEQLLLDTHSLKTFLLSVPSIDSIINSKPPTAYVTSVNAALTKAEMILKVVMCSLETVDEFVEQYIKLLPASDAAEMQKVLEMKGVKRQEHSAVLNAYRLKIGASGSDPIQQSNSLTSRIGGALPTVGSAASVSEAFNAVVSMAADGLSDQAVTSSIDKLKRFERLVKRQL