lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
Sequence:
MHETAVICEVVDIVLKTAKDNFLEKITKVILHIGEFSCIQEDQLKFSYRIISKDTLLESSDLIIEWVKPLAYCSHCNETFPVSFTHKECPICHKVSEKIVSGYDTYVYSIEGD
The following text describes a protein:
Function:
Protein transport. Probably involved in vesicular traffic from ER to Golgi.
Sequence:
MNSNSDYHFLFKVLLIGNSGVGKSCMLMRYSENQFTNNFYNTIGVDFKTKTVAIGEHNVKLQIWDTAGQDRFRTITCSYYRGAQGIIIVYDITDRESFENVKTWIAEIDKYASESVNRMLVGNKADITERREVSYEEGLELSRQFQIPFYETSAKSSINIEAAFTHITKNILNREIHNTKAVVRKTSNMRLQTRQQQQQQQEKKKQEDLCC
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MRQNLTLQQSQQFAILTILTLFDRRITMAEKGDHSAGAGEEEEEVEEVADSPDVFQCQNCREILADSLAMKDPLTGPKACIEMSYISFTAVSETVTVGKTITHSEKQTDRDYGCSYLPLSCAGCGAEIGVMYRGTHSEFDALRDLYTIDINKVTTYSLGSGIPKCSLGGIVSAQEKIDNGLAKIRHVLMTLSKRLSVLEQAMMEEEEPDTKENLTPAPRVKHEVKNERPSGTPSRGNKSSQRPSQSSYGSPVPARTHVRKKARIQLSDYESD
The following text describes a protein:
Function:
Catalyzes the liberation of D-alanyl moieties present on wall teichoic acid (WTA) and lipoteichoic acid (LTA) (By similarity). Affects the methicillin resistance level and autolysis in the presence of Triton X-100 as well as the cell wall structure.
Miscellaneous:
MISCELLANEOUS: Inactivation of fmtA results in reduction of the methicillin resistance and in a modification of the cell wall structure.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKFNKVKLVIHACVLLFIIISIALIFHRLQTKTHSIDPIHKETKLSDNEKYLVDRNKEKVAPSKLKEVYNSKDPKYKKIDKYLQSSLFNGSVAIYENGKLKMSKGYGYQDFEKGIKNTPNTMFLIGSAQKFSTGLLLKQLEEEHKININDPVSKYLPWFKTSKPIPLKDLMLHQSGLYKYKSSKDYKNLDQAVKAIQKRGIDPKKYKKHMYNDGNYLVLAKVIEEVTGKSYAENYYTKIGDPLKLQHTAFYDEQPFKKYLAKGYAYNSTGLSFLRPNILDQYYGAGNLYMTPTDMGKLITQIQQYKLFSPKITNPLLHEFGTKQYPDEYRYGFYAKPTLNRLNGGFFGQVFTVYYNDKYVVVLALNVKGNNEVRIKHIYNDILKQNKPYNTKGVIVQ
The following text describes a protein:
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE).
Miscellaneous:
MISCELLANEOUS: Present with 300 molecules/cell in log phase SD medium.
Subcellular Localization:
Membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MNIKDRTSEFQQSVLSYKKRNKNFREQQRERLQEKESENFANNTTGNGKSVSEFQKKASGIAHEISSTAQLLSKLAVLAKRKPMFNDNPVEIAELSFLIKRKIYAIEQSLVQLSQLKKTDVNGNTSNQSSKQPSAVQHSKNVVNLLNTQMKNISGSFKDVLEERQRLEMANKDRWQKLTTDTGHAPADDQTQSNHAADLTTYNNSNPFMTSLLDESSEKNNNSSNQGELSFPQNDSQLMLMEEGQLSNNVYLQERNRAVETIESTIQEVGNLFQQLASMVQEQGEVIQRIDANVDDIDLNISGAQRELLKYFDRIKSNRWLAAKVFFIIFVFFVIWVLVN
The following text describes a protein:
Function:
Didemethylasterriquinone D synthetase; part of the gene cluster that mediates the biosynthesis of terrequinone A, an antitumor agent. The first step in the biosynthetic pathway for terrequinone A is formation of indole pyruvic acid (IPA) from L-tryptophan by the aminotransferase tdiD. The nonribosomal peptide synthase tdiA then immediately converts unstable IPA to didemethylasterriquinone D (DDAQ D), via condensation of 2 IPA molecules. The symmetric connectivity of the 2 IPA molecules is thought to arise by head-to-tail dual Claisen condensations facilitated by the TE domain. TdiB then catalyzes reverse prenylation by transferring dimethylallyl diphosphate to carbon atom 2' of DDAQ D, to yield asterriquinone C-1. Finally, tdiC and tdiE enzymes robustly convert asterriquinone C-1 to terrequinone A via a transformation involving regular prenylation at carbon atom 5, which requires elimination of the hydroxy group on C-5.
Sequence:
MAPSKTEIAPLRAAKYPFGNIVDALRHAAAHTDEGIIVYHPNSISTSSPPQTVSYKDLLHQAEANATRLLQQKLCSPKSIVLVHFESALDSIVWYWSVLLAGGIPALTGPGMFSQNPADRERHLRHLSETLNSPVCLTRPALLAPFEEQTADDRIKARTVDEILAAPEIADVADAPLPALTPSSTDMLALMLTSGSSGNAKAVPLTHQQLLAAFRGKSTAASLRFPRSPFLSWVHMDHVANLVHCHIFAIVSGISQIQVPAPDLLINPAQLLNLISRHRVSRTFMPNFLCAKLRRQLESGSPEYILDPGLNLETLYIDTGGEANVTEVCIALQSLLSRYGAPDNVFKPSFGMTETVAGCIFNSHCPSYDHAQRHEFACLGKPMPGVRMRVTRLDTPSEEAAPGERGSLEVTGEVVFKGYYNNPAATAEAFTSDGWFRTGDLAFIDSNGNLHLDGRTKEMININGVKYLPYELDAALEQAQIPGATPSYFCTFSSRDATMDTEVVVVLYLPSYVESDDEARFSTQSSIIRVVAMHTRSRPRVVPLRPQDMPKSTLGKLSRAKLKTALEEGQFATQQQINDEAIRRYQQKTRASPETPDEAVILDIIKEQLEIRSDDDSFGVNDSILSIGATSMDLVAIIHRINKCLQPSQPLRLTDILKDSTARGLAVALATGAAPRSQDQSSTHVYDPVVTLQPHGTKSPLWLVHPGVGEVLVFVNLAHHITDRPVYAFRAKGFNAAAGLPETPFTSLEELFTTYRDAIKERQPHGPYAIAGYSFGGMVAFEVSKLLEQDGDEVRYCGSWNLPPHIKFRMRELVWEECVIHLFYFVGLMTELAAYTHKPTLQEFNRANRRLDAIRYLRQHCDAARWDELGLSEEYYLLWVGLASNMQSLAVDYEPSGSVKCMDVFVADPLSHVAKDRIDWVEGRLSAWKEFVREDVRFHDVQGAHYTMLNREYVEAFAGTLKNVLRERGL
The following text describes a protein:
Function:
Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. Also has the potential to transfer a second alpha-1,6-mannose to the Man(8)GlcNAc(2) core oligosaccharide.
Miscellaneous:
MISCELLANEOUS: Present with 9490 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Is recycled between the trans-Golgi network and a late compartment of the endoplasmic reticulum.
Domain:
The conserved DXD motif is involved in enzyme activity.
Sequence:
MSRKLSHLIATRKSKTIVVTVLLIYSLLTFHLSNKRLLSQFYPSKDDFKQTLLPTTSHSQDINLKKQITVNKKKNQLHNLRDQLSFAFPYDSQAPIPQRVWQTWKVGADDKNFPSSFRTYQKTWSGSYSPDYQYSLISDDSIIPFLENLYAPVPIVIQAFKLMPGNILKADFLRYLLLFARGGIYSDMDTMLLKPIDSWPSQNKSWLNNIIDLNKPIPYKNSKPSLLSSDEISHQPGLVIGIEADPDRDDWSEWYARRIQFCQWTIQAKPGHPILRELILNITATTLASVQNPGVPVSEMIDPRFEEDYNVNYRHKRRHDETYKHSELKNNKNVDGSDIMNWTGPGIFSDIIFEYMNNVLRYNSDILLINPNLNKNDEEGSESATTPAKDVDNDTLSKSTRKFYKKISESLQSSNSMPWEFFSFLKEPVIVDDVMVLPITSFSPDVGQMGAQSSDDKMAFVKHMFSGSWKEDADKNAGHK
The following text describes a protein:
Function:
Has a role in cellular detoxification of alkyl hydroperoxide.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSVIEIRSYQHWISTIPKSGYLAVDCYADWCGPCKAISPLFSQLASKYASPKFVFAKVNVDEQRQIASGLGVKAMPTFVFFENGKQIDMLTGANPQALKEKVALISSKATGTGALASSSSAPVKGFASLQGCIENPQLECLNQQDDHDLKSAFNSNPSSFLESDVDEQLMIYIPFLEVVKVHSIAITPVKGETSSAPKTIKLYINQPNNLSFEDAESFTPTQVIEDIVYEQDDQPTIIPLRFVKFQRVNSLVIFIYSNVGEEETTKISRLELFGEPVGDSSKGKLQKVEA
The following text describes a protein:
Function:
Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity.
Subcellular Localization:
Secreted.
Domain:
Consists of 3 PA2-type domains.
Sequence:
MIAFLLTSVLMIPHAGGHPLDTPHLPQELPPGLPNNINITFFSGMFKNVESVAEIFDCLGPHFTWLQAVFTNFPVLIQFVNGMKCVAGLCPRDFEDYGCTCRFEMEGLPVDESDSCCFQHRRCYEEAAEMDCLQDPAKLSTEVNCVSKKIICESKDNCEHLLCTCDKAAIECLARSSLNSSLNLLDTSFCLAQTPETTIKEDLTTLLPRVVPVEPTDTSLTALSGEEAGHDQEGVGAARATSPPGSAEIVATRVTAKIVTLVPAGIKSLGLAVSSVENDPEETTEKACDRFTFLHLGSGDNMQVMPQLGEMLFCLTSRCPEEFESYGCYCGQEGRGEPRDDLDRCCLSHHCCLEQVRRLGCLLERLPWSPVVCVDHTPKCGGQSLCEKLLCACDQTAAECMTSASFNQSLKSPSRLGCPGQPAACEDSLHPVPAAPTLGSSSEEDSEEDPPQEDLGRAKRFLRKSLGPLGIGPLHGR
The following text describes a protein:
Function:
Stress-responsive protein that may play a role in regulation of cell cycle.
Subcellular Localization:
Mitochondrion.
Sequence:
MFSILKQGVISKSLLAATSLKATASRFSFSTSVASRVDGTKNGWSFTASNVADQTTDIGINSESAMSCNDQEQPLSFYVQTVRDDLNSPNWGAEQRKGAFDWEVSA
The following text describes a protein:
Function:
Involved in endocytosis.
Sequence:
MSKLKGSRLEAEIDRVRADANWKRLSELLPSVKSKNSGLEDCYEMFQAEIVLETYLDHLGEIIRPSHDHMDKLSSAEQLLHEALKGHSDNYTVKIEANILLAKCLYACLEFRKALQCISNSEMENGKTPFRTLRTLRLVAEGYAIKGLCIESMEEVPTTRPHSNSTTSTSSSASSKDQRALYVFEKSAELAIFYINELEKSINSSSQAAKPVGTVTPNSQAAGVRQQEKIGELLERIMERVAIIRAKDTAAKKVSSGTEGIEWYRKIITCLGDKFTGERLKQKLSRQFAELLIRATVPIEEKSMSEAMHTKAMNMKLYHGSNKTFYTPKSKIEEIILLLLINEVLSTREVILSRTDDLSSSRTLSLQNAKSSFNLLTLVLSTINQYQLLAQIYERAMKFANNDSFLWQQFALSAICCGRFSRAIRVFEQSILASTIASESLTSSASSTSSISSQNSTSKAQNLHQNRRPKSPDSAMFSSLKLTNNPSCALSVISEYMMISQVLIERFGNYEPAIEYASKAVDLCSKEGQLSFLKARCQLLHAIAYGFRASEEPSWDLKKAQLAKTVQLIEECVSIDAHDYLSLYYAAYFHAISRDLESAKDRCSRSLALNGDQPAAIMLLALIFTAYGDLKGALDLVINSLAEFEHNYGLMVLRLHIETKFGRIEESLDTCSHLLDFWKKQPPVQQQLAYSGGILDEERSQRTINGAAEQLFGGGGATPSQKTGTPSLGRELSTPLATTPLIPMNFPLSSALPVISAIPSNASTMDLSGAAESIVGGGASEVGGAASTNSDSLNSGIGDAWSKFRTQADVWMCLAELYINEGRHADLTKVIEQAITMFPSSPQALYLKGRLLVSRCQKLADETLVSRIRGEAKSAYLAALALAPGHFQSMSALAKLYEEEGNQKMAEHMLREMVRVDPLNCEWWQQLGCSLMKRGDSDRATECLTAAAQLDRSTPLLPFSVVPMVFPANFR
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MAPFLLALLAVLLPAAPPSLGAGYGEGGAGTINITKTLAGFPEFSVFSAMLTETSVALAINSRDRATVLAPNNTAVAAAFGGLPHIPRSFLADLLALHVVLDYVDEPRLGALERGRTGRGSVVTTLLQVMRAVPRGTGFLRVYAGRDGRATVSSAAPAGLRNATVERVVAAQPYSLAVLQVSGFVVPPGIRVPKPFPPPRARHMAAPPGQAPVAAPGPQQEPFVGSGPLVPSPIRPVPTPNLTNTPPALGETGIIPIPSVHGGMAAKVPSPAGRSATSWWNGVAVAFGIMTCLNLHL
The following text describes a protein:
Function:
Catalyzes the exchange of ADP and ATP across the membrane.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVGGDGEEPGLQRQAKRALGDPLPLDNEMESEAPNDFSNDPSDNISVQSLQVACVQKCCLCTIVAPLDRIKFVMQCQKELQRTGVLDRTFRSSWHCFRCIHSIEGIRSFWRGNLVQVGSLLPVTAAHMLLGGPMQMWVYNNFPRGFPFGHSAATYASILCGALAVSAVSYPLEFARFRLAVDLRRSPCDLYDYRHSLAFFAQSVFSEAPHLLYAGFGLYVTGSIIYGVMYTGLTQQVLSRLPSEPGGYTATVVQVGAGVGVSAVSTLGLHPLDTMRRRMMIAVTMDGLRYASARHCFHHILSTEGIAGFYRGAAFTMVRMVYISSLYMWFLPAA
The following text describes a protein:
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Sequence:
MDNGNNEILYSVKISEPRDKNSTGIYRHPEYKDKLCENFDDKKFNNMWEVFDRVSTKFKERDCMGVREKLEDNKRGAYQWKNFGEVKELIMKVGSGLLNMNACPLIMCDDQRIPKARFLGLYMPNCPEWNICDLGCNAYNIITVPLYDSLGPQSSRFILDQTQMETIVCDKTCARNLFKSLETCEEIYLKTLILVDEIDDEIKKECSKYNLKIILWEELIKQGEKKIVKVPQGALNNIFSICYTSGTTGYPKGVIMTNRNFIGILAAAYIGPSRLPDLCINENDIHISYLPLAHIYERLMIYLFMAHGVKVGYYSGNVQTLLEDIQELKPTLFISVPRLYNRIHERIFNSLKKKSGLVQSLFNKGLQNKIKRLSSSGSTTHVLWDKLLFNKAKKILGGHVRAMLNGSAPISVDVVKKLRTIFCVPMFEGYGMTESLGASFITHSQDRNIGHIGGPVPCIEFKLVSVPEMNYLVTDNPPKGELYLRGPSTCNLGYFKLEKETNELLEKDGFIRTGDIALLSPNGSLTIIDRKKNIFKLAQGEYVAVEKVEASYKQSLFISQIFVFGYSYESVLVCVICPSTDSIDIWRTQKKIKATDEEVIKLPEFKADVINDLTSIGKKDGLKGFEQIKDIHFTLEAFTIENDLMTPTGKIKRHEAKKRFKKEIDEMYEKLKQ
The following text describes a protein:
Function:
Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MANRKRDAGREALEKKGWWRSHRWLVLRRLCQFFVLGMFLSGPWFGVWILHGNYSSSLLFDTVPLTDPLMTLQSLASGHLPATVALTGAVIITVLYALAGKRLFCSWVCPLNPITDLANWLRRRFDLNQSATIPRHIRYVLLVVILVGSALTGTLIWEWINPVSLMGRSLVMGFGSGALLILALFLFDLLVVEHGWCGHICPVGALYGVLGSKGVITVAATDRQKCNRCMDCFHVCPEPHVLRAPVLDEQSPVQVTSRDCMTCGRCVDVCSEDVFTITTRWSSGAKS
The following text describes a protein:
Function:
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Subcellular Localization:
Nucleus.
Sequence:
MERTKKSACRSLFGPVDHEQLRQDLQQELREMTERDSQRWNFDFQAGTPLPGGFQWEDTPADRAPALYRDSLTCPSGGEKSADTNQENCFNISNKCAEEKTPVQRRRKRRPLSKPGAKRKADARNWFILTCKRRKGKKKQSILHCFKGTVSVMFQSMIKLSSGSRRFHSFQLTSTI
The following text describes a protein:
Function:
Binds to cytosines in base mismatches and opposite chemically altered guanines. May be involved in repair of DNA damage.
Subcellular Localization:
Nucleus.
Sequence:
MVFAIRIRQFHTTLVSAEKNGLQKLIPPRLKTIWNQMLVETKGAGNGPERFEMIRQKYKALTADEIQKYKNKLQEQFDAEKKRFMETLRSFTPTEIDSENRRRSKEAHSTGSRYYRLRHPDVPKKPSSAFILFYKELRNNPKLRQELGIPEAISTLVEETQNASKAWKELAEDKKKPFIDKSKALKEQYDKFMKEAGFR
The following text describes a protein:
Function:
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTSGPVFFYILIIGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYSKMTSPYPFEAETPECSFHFFLFITLLFLAPCHHALPLPLDSVVSSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINYLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIQNRVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHQFWYNYRQRRSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
The following text describes a protein:
Function:
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSVNVTLSGPPPWGFRITGGRDFRKPITVSKVTECGKAAQGDLRPGDVIVSINGESTSEMLNVEAQNKIKQSSGRLQLLIDRTPQFSLSQTNGESSPEMLSIQFQGALRTRDDGQNSVRSSFSSPASISPRPSSPFSPPSPGGRSGSPYSPRRTSLSGEGREDPVANNRSFQSLVSPARVSEERSPPLQGQQYSSSRQERRSFTPPSGPPLPSLPPLNGSPSSGSYTLCNPWEIRKEQNRSPSSPFHRSYSLDSEAAMHRLEGDSEVYKMMQENRETRAPPRQSSTFRMLQVALELDEKDGTATHFPSQLSPNNAHKPVNSSATGSSPKMHTCEKCGGGITNQAVRIQENRYRHPSCYTCTDCGLNLKMRGHFWVGEEMFCEKHARQRYQGPAGGSIATAVYSQS
The following text describes a protein:
Function:
Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region.
Sequence:
MHNMSDIIEQYIKRLFEESNEDVVEIQRANIAQRFDCVPSQLNYVIKTRFTNEHGYEIESKRGGGGYIRITKIENKDATGYINHLLQLIGPSISQQQAYYIIDGLLDKMLINEREAKMIQAVIDRETLSMDMVSRDIIRANILKRLLPVINYY
The following text describes a protein:
Function:
High-affinity low glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell. The transporter-like sensor generates an intracellular signal in the presence of low levels of glucose to promote low glucose-induced expression of HXT2. Binding of glucose to the SNF3 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (By similarity). SNF3 is involved as well in the transport of mannose and fructose. Even though SNF3 is similar to glucose transporters, it appears to be unable to transport glucose.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The C-terminal cytoplasmic domain seems to be important for SNF3 regulatory function.
Sequence:
MDPNSNSSSETLRQEKQGFLDKALQRVKGIALRRNNSNKDHTTDDTTGSIRTPTSLQRQNSDRQSNMTSVFTDDISTIDDNSILFSEPPQKQSMMMSICVGVFVAVGGFLFGYDTGLINSITSMNYVKSHVAPNHDSFTAQQMSILVSFLSLGTFFGALTAPFISDSYGRKPTIIFSTIFIFSIGNSLQVGAGGITLLIVGRVISGIGIGAISAVVPLYQAEATHKSLRGAIISTYQWAITWGLLVSSAVSQGTHARNDASSYRIPIGLQYVWSSFLAIGMFFLPESPRYYVLKDKLDEAAKSLSFLRGVPVHDSGLLEELVEIKATYDYEASFGSSNFIDCFISSKSRPKQTLRMFTGIALQAFQQFSGINFIFYYGVNFFNKTGVSNSYLVSFITYAVNVVFNVPGLFFVEFFGRRKVLVVGGVIMTIANFIVAIVGCSLKTVAAAKVMIAFICLFIAAFSATWGGVVWVISAELYPLGVRSKCTAICAAANWLVNFICALITPYIVDTGSHTSSLGAKIFFIWGSLNAMGVIVVYLTVYETKGLTLEEIDELYIKSSTGVVSPKFNKDIRERALKFQYDPLQRLEDGKNTFVAKRNNFDDETPRNDFRNTISGEIDHSPNQKEVHSIPERVDIPTSTEILESPNKSSGMTVPVSPSLQDVPIPQTTEPAEIRTKYVDLGNGLGLNTYNRGPPSLSSDSSEDYTEDEIGGPSSQGDQSNRSTMNDINDYMARLIHSTSTASNTTDKFSGNQSTLRYHTASSHSDTTEEDSNLMDLGNGLALNAYNRGPPSILMNSSDEEANGGETSDNLNTAQDLAGMKERMAQFAQSYIDKRGGLEPETQSNILSTSLSVMADTNEHNNEILHSSEENATNQPVNENNDLK
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MSTIPEIRTLPVPDGLEGERVDAAISRMFGFSRTKAAELAAAGKVQVDGSVVGKSERVHGGAWLEVEMPQAPAPVQVVAEPVEGMEIVHDDEDVVVVVKPVGVAAHPSPGWSGPTVIGGLAAAGYRVSTSGAAERQGIVHRLDVGTSGLMAVAKSERAYTSLKRQFKERTVDKRYHTLVQGHPDPTSGTIDAPIGRHPQHDYKWAVTAEGKPSVTHYDLIEAFRAASLLDVKLETGRTHQIRVHMAAHRHPCVGDLTYGADPTLAKRLRLTRQWLHAVRLGFEHPGTGDWVEYASEYPDDLQQALDLVREETYG
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAKTALIMPMKEMCKTSQWILILLHVQQSQTLKGVSHSLMQHRSWMQIVTMAAESDVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEFQGHKVILAACSTFMRDQFLLTQSKHVRITILQSAEVGRKLLLSCYTGALEVKRKELLKYLTAASYLQMVHIVEKCTEALSKYLEIDLSMKNNNQHTDLCQSSDPDVKNEEENSDKDCEIIEISEDSPINIDFHVKEEESNVLQSTVELTSERKEMKSPELSSVDIGFKDNEICILHVESISTAGVENGQFSQPCTSSKASMYFSETQHSLINSTVESRVAEVPGNQDQSLFGENTEGSHGTVNEMQNLDDAYSLRHQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMGIRPFQCTVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSVHGRSSSEKLPRHDLKRQNLL
The following text describes a protein:
Function:
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
Subcellular Localization:
Cytoplasm.
Sequence:
MMVLEGASALSPFRRARLETRLQTLVPALRLTGAWHVYFIRADAGRTPDQATLQRILQAEPAPAPRDEAASSRYVVPRLGTLSPWSSKATELMRGAGQPIQRVERGTRIDLAGWPEGEADQAAVAKLLHDPMTQSLLGSAAAAEALFNVPDPGQLERIPLDALEQANGDLGLALAQDEIDYLRERFAALGRDPADVELMMFAQANSEHCRHKIFNASWTIDGKPQERSLFRMIKHTHQQTPQHTLSAYSDNAAVVEGVPAARFRPDPATGEYRSEAVVPSAFAIKVETHNHPTAIAPFPGAATGAGGEIRDEGATGRGGKPKAGLTGFSVSHLRIPTLPQPWEAPRALNPRMAPALDIMLDGPLGGAAFNNEFGRPNLLGYFRSFELAEGQGLTRAYDKPIMLAGGLGAIDRNQVEKLRLQPGDAVIVLGGPAMLIGLGGGAASSVAAGDSAEALDFASVQRENPEMERRCQEVIDHCVALGTDNPIRWFHDVGAGGLSNAIPELLHDSGVGGVIDLARVPSDDPSLSPLELWCNESQERYVLGVPQARLDEFAAICARERCPFAAVGVATAEERLVVGYGVFDAANRESGIGNRNSALPAAEAASAHSLFPTPDSPLPINLPMDVLFGKAPKMHRDAVHPAAPQWPVLQTGALDLQEAGLRVLAHPTVASKSFLVTIGDRSVGGLTAREQMIGPWQLPLADCAITLAGFETFDGEAMSIGERTPLALLNAAASARMAVGEAITNLCAAPVQTLDSIKLSANWMAAAGHAGEDALLYDAVRAVGMELCPALELSIPVGKDSLSMQAQWQVGNGESGIGNGETPAPSASAIPDSRLPIPGETLKSVSPVSLIISAFAPVSDVRTQLTPLLQREDESELWLIGLGGGKQRLGGSVLAQVYADDSALPAFGGETPDLDDPQRLRQFFELIRDAREGGLLLAYHDRSDGGAFAALCEMAFASRQGLDITLDAWGDDAFRSLFNEELGAVVQIANEDRAAFADLVERHALTECAQRIARPTGTPRVRVSGQGRVLAEWRWEALFDAWWSVTHAMQKLRDNPDSADEERAVARNFQAPGLRPKLVFDPSEDVAAPFVATGARPKVAILREQGVNGQIEMAYNFERAGFRAFDVHMSDLIEGRVDLAQFAGFAACGGFSYGDVLGAGRGWATSILERAALRDAFAAFFARSDTFALGVCNGCQMLSQLKDIIPGAEHWPRFLRNRSEQFEARTALLEVVESPSILLRGMAGSRIPVAVAHGEGRAEFDTAVDQAAARVALRFIDGDGAVASQYPLNPNGSPDGITGLTSTDGRATILMPHPERTPRSVNLSWHPAGWGEDSPWLRMFRNARVWCG
The following text describes a protein:
Function:
Potential ligand of the IGFLR1 cell membrane receptor.
Subcellular Localization:
Secreted.
Sequence:
MVPRIFAPAYVSVCLLLLCPREVIAPAGSEPWLCQPAPRCGDKIYNPLEQCCYNDAIVSLSETRQCGPPCTFWPCFELCCLDSFGLTNDFVVKLKVQGVNSQCHSSPISSKCESRRRFP
The following text describes a protein:
Function:
Acts in signal transduction. Negatively regulates the pak1/shk1 control pathway.
Subcellular Localization:
Cytoplasm. Note=Localizes to the cell ends during interphase and to the septum-forming region during cytokinesis.
Sequence:
MISSFSNGFWSKDYATGVKKLFDCLDNGVEENEQVKNLLKLYKEANEEFGEKLQEITKECLKGKKPENTEDGATSNKAFEGLRSEIANQGKQHIRIAKDLETLIIAPFSKMSIDHSQKLQTSQQVLTNQIKSYEKKYYTLKKTKSAYYNKCRNLEDYEEESKESNETTSEAITDLTTVSSPQQQSLLENDDDLIQLGFMEFRPEELKEVLAQVLQEIPLQDYRVPILGTYPNTCSGNIIVSWLQENLPVPTLVAAEAFGQDLIAQGFLRHMGVGGSFVNSTNFHYQWKDKAFQFAGLNSVDSLVENAKALPLVGEYLSDYISHRKLYSSETQSQRLKREVLDANKIYSESVVDLDKCRTLVEETIADHLQFLQKCETDRVLYYKDFFMDLSTIISNFLPSMKLLADQIVVYQEIIQPESDIRYILESAATGPFLPRVEIYEDYYNDIKDQIFGVDVEFLSHRDKKRVPIIVSTILSYLDLLYPTLASDEVRQNIWLVNSPLSSVHQLREALNHSSSVTKEVLSQYTPSVVIGVLKLYFLELPDSIVPSSAFELIRSIYMNHSNDTPYRLRLLQNLLSQLRRVNLATLSAIITHLNRLITLTPNKETFTINLANSLSLCISRPATWNLGIQHDKHPTKFMEDLLTYGPSIFEELRKLNSSKRVSDRVLYQSSATPRSTDVSPTRPDSISSVRSHTAVESPRSSFEELQPSEIPAESEFTLENVPTSLIRSSYALNTRKTRRNFSHSSASNESAAIFIDQDAKIVNEAVASRDSSLSGS
The following text describes a protein:
Function:
Probable transcription factor. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Inhibits neurogenesis.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Nuclear export to the cytoplasm is promoted by btbd6a.
Sequence:
MDLTKMGMIQLQNPNHPNALLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKVEDLDDLLYAAEILEIEYLEEQCLKILETIQSSDENDTEVNMNDGGTEDDEERKGRHGRNLVGSKKHSTEESGYVSAAQQALALPGMVDQSPSVSTSFGLSTMSPTKAAVDSLMSIGQSLLQSTMHPGVGAEQPLHGNSHPMMGEIKTEMMQVDESGEHESPKAMESIASSNGERSGEPDKNRDGPGTPTRSSVITSARELHYVRDEGLGDQQAEVSQMGLEAMAGMTEKHLASLYGIPSNHKNEAMLSMPASMASSLHMSPALAMSMDFSAYGGLLPQSFIQREFFSKLGELAAGIKPDGRSLNERCNVCGAELPDNEAIEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLSHSAGEKAIVCDQCGAQFQKEDALEAHRQIHTGSDMAIFCLLCGKRFQTQTALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTAGDHPFECEFCGSCFRDESTLKGHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICLEYCPSLSAMQKHMKGHKPEDIPPDWRIEKTYLYLCYV
The following text describes a protein:
Function:
Telomeric DNA-binding protein that negatively regulates telomerase and telomere length.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome, telomere.
Sequence:
MNEKIRSQSVLNTLETFFIKENHYDMQREESSIVNACLRYLGYSKSMCHEKMPIFMDIAFIEYCFNLSLDPSSFQNLPITQTQPDSQQILWEYSLISNALERLENIELERQNCMREDGLVKYTNELLLNKETLNNEALKLYSCAKAGICRWMAFHFLEQEPIDHINFTKFLQDWGSHNEKEMEALQRLSKHKIRKRLIYVSQHKKKMPWSKFNSVLSRYIQCTKLQLEVFCDYDFKQREIVKMLTSNIN
The following text describes a protein:
Function:
Promotes dephosphorylation of tyrosine 3-monooxygenase TH which decreases TH catalytic activity and leads to reduced synthesis of catecholamines including dopamine, noradrenaline and adrenaline. The exact mechanism of activity is unknown but may act as a phosphatase or promote the activity of phosphatases or may inhibit phosphorylation by acting as a barrier to interfere with protein kinase access.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVESGSAQERGILLESLSTLLEKTTASHEGRAPGNRELTDLLPPEVCSLLNPAAIYANNEISLRDVEVYGFDYDYTLAQYADALHPEIFSTARDILIEHYKYPEGIRKYDYNPSFAIRGLHYDIQKSLLMKIDAFHYVQLGTAYRGLQPVPDEEVIELYGGTQHIPLYQMSGFYGKGPSIKQFMDIFSLPEMALLSCVVDYFLGHSLEFDQAHLYKDVTDAIRDVHVKGLMYQWIEQDMEKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQADKPSFFTDRRKPFRKLDEKGSLQWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLNYRVDFTFYPRRTPLQHEAPLWMDQLCTGCMKTPFLGDMAHIR
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MGAGKTTIGKALSQELQMDVVDTDQKIEEKQEKAIRNIFAEEGEMAFREYESEMLRALPVHNVIITTGGGIIERAENRKWMKENGTVVYLYCDPHVIAERLREDTTRPLFQKKDIDAFVTKFESRRAYYEEAHIHIDTTNKSVKQIMNELKEKINV
The following text describes a protein:
Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MVVGSLKLWTNLVVEGFQKSLSIAKFLCLLHATNAYICTPITPYGPSMLPTLNLTGDLVLVERVSTWLGKVDRGDMVLLRSTEDPRKVVIKRIMAMEGDTVTYLVDPKNSDASKTCVVPRGNIWIQGDNIYNSRDSRTFGAVPYGLVEGKLFWRIWPLKSFGSLHGEAKEDS