lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.
Subcellular Localization:
Cytoplasm.
Sequence:
MAVGELYSQYTRVWIPDPDEVWCSAELTKDYKEGEKSLQLRLEDESIREYPIDVQSNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQAEDERNYHIFYQLCAAASLPEFKELMLTCAEDFFYTSQGGDIRIEGIDDAEDFEKTRQAFTLLGVRESHQISIFKIIASILHLGNVEIQAERDGDSCSVSPQDEHLNSFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARNALAKHIYAQLFSWIVEHINKALYTPLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEEIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSGSQHFQKPRMSNTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDSVSATTTSGKGSSSKINIRSARPPLKASNKEHKRTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLVKKRELTSTDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADRFRAATIMIQKTVRGWLQRVKYRRLKIAALTLQRYCRGHLARRLAEHLRRTRAAIVLQKQCRMWRARQAYQRVRGAAVVIQAFARGMFVRRIYQQILLEHKATILQKHLRGWMARRRFQRLRGAAIIIQCAFRMLKAKQELKALKIEARSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKSLSEQLAVATSTHATEVEKLKKELAQYHQSQGGGGLRLQEEVENLRAELQRAHCERKVLEDTHTREKDELRKQVAVLEQENALLKDEKEQLNNQILCQAKDEFAQNSVKENLLMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDALQQVEDVGLEKAAMDMMVFLKLQKRVRELEQERKKLQVQLEKREQQDSRRVQVEQAKNDLDVDQDADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQDNSSHCSPDGYSLLLNQLKLANEELEVRKEEVLILRTQIVSADQRRLTGRSTEPSINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQGREHEAEVEALRAQVEALKEDLDRQQQTFCQTLLLSPEAQLEFGVRQELTRLTNDNLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERRRHELNRQVTVQRKEKDFQGMLDYHREDEALLIRNLVTDLKPQMLTGSVPCLPAYILYMCIRHADYINDDLKVHSLLTSTINGIKRVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMVDGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLQQSGAVQTLEPLIQAAQLLQLKKKTPEDAEAICSLCTSLSTQQIVKILNLYTPVNEFEERVTVAFIRTIQAQLQERNDPQQLLLDSKHMFPVLFPFNPSLLTMDSIHIPAYLNLEFLNEV
The following text describes a protein:
Function:
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Subcellular Localization:
Secreted.
Sequence:
MPRLCVCMLVLVLALATFSEASWKPRSQLQDASSGPRTNGALEQHQLEKLGPASHHRRQLGPQGPQHFIADLSKKQRPPMEEEEEAYGWMDFGRRSAEEEDQYN
The following text describes a protein:
Function:
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Sequence:
MFSFLCLVELALPMSKTLVDSYGRRIRKLRVSLTDQCNLRCHYCMPVDAIFLEQSSYLSCQEYGEIIGELIALGLEEVRLTGGEPLLRRNFTEIVRAIGQLKLKKIGLTTNGIVLDRHLDTLGENNVLDLNVSLDSLNAKTFSEITHRNCLNTILRNLELASRQGFKIKLNTVVMREINDREIFDLIEYAKRWEMEIRFLEIMRIGYACRHQEKTFISAQELLAKIQQKYSLKPIQSALDATAFRYSTSCGGIIGFIASESQPFCGHCSRWRLSVDGTLRACLLKNEGINIRNFSSLERQHVYQQLLGMKPYLRPPEVSHAMHQIGG
The following text describes a protein:
Function:
Probable transcription factor (By similarity). Seems to promote cell differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MSQSNMVPVANNGDNNNDNENNNNNNNNGGTDNTNAGNDSGDQDFDSGNTSSGNHGEGLGNNQAPRHKKKKYNRHTQLQISEMEAFFRECPHPDDKQRYDLSAQLGLDPVQIKFWFQNKRTQNKNQQERFENSELRNLNNHLRSENQRLREAIHQALCPKCGGQTAIGEMTFEEHHLRILNARLTEEIKQLSVTAEKISRLTGIPVRSHPRVSPPNPPPNFEFGMGSKGNVGNHSRETTGPADANTKPIIMELAFGAMEELLVMAQVAEPLWMGGFNGTSLALNLDEYEKTFRTGLGPRLGGFRTEASRETALVAMCPTGIVEMLMQENLWSTMFAGIVGRARTHEQIMADAAGNFNGNLQIMSAEYQVLSPLVTTRESYFVRYCKQQGEGLWAVVDISIDHLLPNINLKCRRRPSGCLIQEMHSGYSKVTWVEHVEVDDAGSYSIFEKLICTGQAFAANRWVGTLVRQCERISSILSTDFQSVDSGDHITLTNHGKMSMLKIAERIARTFFAGMTNATGSTIFSGVEGEDIRVMTMKSVNDPGKPPGVIICAATSFWLPAPPNTVFDFLREATHRHNWDVLCNGEMMHKIAEITNGIDKRNCASLLRHGHTSKSKMMIVQETSTDPTASFVLYAPVDMTSMDITLHGGGDPDFVVILPSGFAIFPDGTGKPGGKEGGSLLTISFQMLVESGPEARLSVSSVATTENLIRTTVRRIKDLFPCQTA
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSDLNKELVDLVWGRPSGSSMPNTVFCRWTQGFVFSEAEHTALEQFEGGPCAVIAPVQAFLLKNILFNSERSNWRECSEEDQKAVLCYTLSEILETACFNKSKSYCLATWSKGKVSEDNSSISESSPESSQQSEDEQHCLAALATEELGFERFHTIIQKRILKTSGEMKEAVLDLYDTWRNKFGVLLFLYSVILTKGIENIKNEIEDATEPLIDPVYGHGSQSLINLLLTGHAVSNVWDGDRECSGMKLHGIHSQATIGFLTLMESLQYCKVGAFLKSPKFPIWILGSETHLTVFFAKEMSLVAPESPSEQARRVFQTYDPEDNGFIPDTLLEDVMKALDLVSEPEYVNIMKNKLDPEGLGIILLGPFLQEFFPDQDSGIPDSFPVFHYNGLKQSNHNEKVMYVEGTSLILGFEDPMVRTDDTPIKRCLQTKWPYIELLWATDRSPSLN
The following text describes a protein:
Function:
Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism. May act in a common pathway with retinoblastoma-like protein homolog lin-35 and hpl-2 to influence the ER stress response in the intestine. Plays a role in recruiting chromobox protein homolog hpl-2 to specific chromatin sites.
Subcellular Localization:
Nucleus. Note=Localization to nuclear foci overlaps partially with chromobox protein homolog hpl-2.
Sequence:
MDEFELFQQLNQTAPLVKTEEPEVPDEFQQANNNQSAPLRTGLSDLSHEIAAAKQREEEEAQRLADFMQKDMKEPAVKRKRGSEEYKKDPLESKAPLSTFGHSSRPRRSVNYASIERGDEAQAQSLVTDFGSRGNRKKPKRTRDELDENYMEENEGNSGRKKKPNAKGASRQFQVPGLPTYASQYSRPPKQEDVFKTIVPLAEDARAEGERVIGFRLDSQPAVRRASGGFRRFCAWLSDNQIFSIMQTVDKLCIVGANNEDHDEILLKSIRHVYNAMPPTFRRDWEYAARKDVFDSRLFVQNMPMPLSEISVTDPRHPPSPIARGTTVRPNCCENQPLFLNMCETIEHYLGHHDVVHLFGCDICYRVYPSRYELTKHDCKEFAEYLRQLTFKQQTLHLEAAYMYLCCSQCGLWLSVKPSGEGKKGWTYFATALMNHSCQPLVPVVAYFPKPLKDEGKGIRIQFQVMSELNIGLPLSCSECNIEEFHSVVEIEEHFKEKHEANHTCIKCGKTFGTEFMLKHHAQSHTTQTAQFANYLQMSATYQPPPSSGRLPYVGFGSSIPAIGGLTSGEVQALEASENKKSEFVEPDEYTIRKKLLRWKHAKTKKENRNITDSNEKEFSYEPGESSGEEDFQKSLLEQDNQSSSSSDSDSDSDDFTSSKQKKKRNIKIRGDLGYEHINRNKFFERPESEKEARKRIEKVYKKHVLLSRERLLDPEEALRILEESRMVHLNSIQSTLADDIAMSCIRTISLPASNCIDPLKDLLLVNKIFYFCTKCNYIFSKDPVVHCLSCEVTEDDLIEVYHAASGPHAGVRCIDPECKAHLCSVISLKTHLSDVHSKQATLELVSGELDNFSENRFDRSLMLMAKHFTQLQFDERTYLARFTDIECFMPFSGLLEAKDQPRPMPIRQQPQQIKPAYSLVRPDIIAPNELMRPYTLTPAIRPGQRIKPYKVPRTSRWYSCSWCDREYESLNQFVDHLTRFHTHPCPSCGKAFSSQNTRRTHVCSRLFAEIKGRGATLCGQCPSCPEIHQVERIFVHMLNRHFSTIEYVLATGELLPPARDVGIRYNHGENGGYGRSYESLRAIEQSVVDPRSPDYRLKQVKISALPIHGVELNRLPARDPPMGSFTVCPPKDKNIDPRLMCYMCELTFDSYDELTHHMDDHPEKWANCPFCAANTPTHFDLQKHLIQEHVVQISGQACCAFCQEHHRFMSSHILFRCKRVSRCTICGVKSNDPLANRVHIQRSHALTLRRFQCAYCIKVFVSVGEYYEHECASGGGRVYSCTCSPNKFFNSPIEFCDHFDSVHILRNKCQLCSYDAPSQDGMVKHRKTHMRSGCPKEQTKKLFILMKCLFPKHNSGYMRFIEGGPVPASYQDVDRSQMNYLMCNMGTVSPSCHKSYAQAPRTLLEALEGVASDSRSGGLQKVVNVTTRMNEPSSSDVIMLSDDEDDDCVVFEKAVPNGVAQGSSTSTPNPESSINCEVRVETSQAGYGGAQQPGYVDEDDTDLEVAQGGKSPYGEPVVKEVVDENGDDELAVVAEVENSTGTLPSSISAGREKKFKCQKCSLAFYTNGSLESHMRDHRQDAGAQLCTETYGIPVVTKASWLCRNCCVVFENQPKYQKHMAIHGDTCLTCIHCSGIAFNHTAIQNHMKSHEEKKVRYSCGTCLCTFASDLALFDHLSVAHGVSLYYFCKVCGFGSTSADSVFQHISIHNGHNYSLVQRFGACPAQLLNYDPTDELEFRSQILNKTIQLVSPSDCSHRSMLLQCETVVSCKTCHCTQAWFNYMAFNNHSEETGFPQFKNVDLANDYRRDFPLSRHLNERNALSMSQFGNAKHGSANHSHGQAQPNKRTFRHEVPYRTAAPRSSLQTNGSSMGSVTTNGGRVVRPSPPNSMNVTLRRAPPQQAPPRRIVIANSAPNNTNVLRNHVAVTTKCQFKDCDKVLHSEFDRQLHSMHSSNSSWFCRQCGHSPKSEIDLFLHYIQVHLKPAYDKHQSNSFKSNVFHLKCPIRSCTSPEFQSPKAFEKHMRTAHAAELPFEASCCDARFASKALCVKHDQEHASFLDSNGTDASCCPICGSLSMWSLPKDPHTDCLQSHIIRHGLDYRSSCRQCLKQFPADVNQDQVIAHILDTHGMSMHGNTFHCNLCTTGTKTVEEFAEHCRKAHVFHILVKSSHSTRGELVVTTGQEYENYVGLKSVTRASLNSISSQRASNAGETAQPSVLCAGSGNAALLTIAAAIGEPETSNNTAEVLTLD
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MSNFSTPPFDPRFPNQNQTRNCYQNFLDFHRCTKIMKRRGKDSSPCDYYRKVYHSLCPLSWVQRWTDQIREGTFPGKI
The following text describes a protein:
Function:
Epithelial intermediate filament protein.
Subcellular Localization:
Cytoplasm.
Sequence:
TSKISTTYEEEGRQSKIQPRAFVITRSGPTSRSSSYSARQSYGSRSSITPGVYQQLSSSGITDFRGTREKEKREMQNLNERLAGYIEKVHFLDAQVKKLEAENEALRNRKSESLQPIRDAYENELAQARKVIDELSSTKGVSEAKVAGLQDEIASLRELIGTYENQSKDYRKKIESLGNQIGEYEGELHTLRIRCGSLEDENAKVRELLDKIQDQNRRLRADLDTETSAHIEADCLAQTKTEECEFYKDLLDQLELLKPEPMQIKGMDYAEFWKSELSKCVRDIQSAYDEKIDIIQQDIEAKYSSQINSLRSGNVKDGMQLQHVQEEVKKLRTQAGEKNAAYAELAAKFASLQAERDAIGRQCSELERELEELRIKYNQDIGDLSNELSAVLAQLQTLTDVKITMELEIACYRKLLEGEESRVGLRSLVEQAIGVQGRGTASLKDTIQQS
The following text describes a protein:
Function:
Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway. However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
Sequence:
MKKGFLAAGVFAAVAFASGAALAEGDAAAGEKVSKKCLACHTFDQGGANKVGPNLFGVFENTAAHKDDYAYSESYTEMKAKGLTWTEANLAAYVKDPKAFVLEKSGDPKAKSKMTFKLTKDDEIENVIAYLKTLK
The following text describes a protein:
Function:
Transcriptional regulator that causes a severe detrimental growth effect and reduces cell viability. When expressed, it alters expression of a variety of bacterial regulons normally controlled by the transcriptional regulatory protein RcsA, resulting in deficient lipopolysaccharide biosynthesis and cell division. YdaT has no effect on Rac prophage excision. Overexpression of ydaST reduces growth and leads to loss of cell viability. May contribute to toxicity and morphological defects.
Miscellaneous:
MISCELLANEOUS: Encoded in the Rac prophage region; MISCELLANEOUS: The ydaST locus was predicted to encode a toxin/antitoxin (TA) pair in a genome-wide prediction of TA pairs, however it was shown in subsequent studies that it does not form a toxin/antitoxin pair. Whether or not the YdaST-RacR module forms a toxin-repressor combination or an atypical toxin-antitoxin system, or whether they are actually essential regulatory components of the prophage genome, has been debated.
Sequence:
MKIKHEHIESVLFALAAEKGQAWVANAITEEYLRQGGGELPLVPGKDWNNQQNIYHRWLKGETKTQREKIQKLIPAILAILPRELRHRLCIFDTLERRALLAAQEALSTAIDAHDDAVQAVYRKAHFSGGGSSDDSVIVH
The following text describes a protein:
Function:
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MLNEPLPSSMEDNPQFKEETSLQKFRRRLKEEPLIPLGCAATCYALYRAYRSMKAGDSVEMNKMFRARIYAQFFTLVAVVAGGMYYKTERQQRREFEKMVEQRKAQEKRDAWLRELEIRDKEDKDWRERHAAIEAAAKEAGKRPAPKKLPEQDAARSAIEPADERSIGVLSAVRDLWMQQK
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MESAARRSGGGVLEGFYRLVMRRTPVYVTFVIAGALLGERAVDYGVKTLWEKNNVGKRYEDISVLGQRPVDE
The following text describes a protein:
Function:
Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic condition uses ubiquinone as an electron acceptor.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MKTLILFSTRDGQTREIASYLASELKDMGIWADVVNLHRAEEPDWDSYDRVVIGASIRYGHYHSAFQEFVKKYATRLNGMPSAFYSVNLVARKAEKRTPQTNSYARKFLMSSPWRPDYCAVIAGALRYPRYRWYDRLMIKLIMKMSGGETDTSKEVVYTDWEQVAHFAREIAHLTNKSSAK
The following text describes a protein:
Function:
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.
Sequence:
MSAPVADAPAAEIVYKIISSDGVVSKMSEKAVQQSKTLSNLIENLGYTIENIETRDPIPVTNVNGKTMAKVAELCEKHKADAIPEDNMNVLKTLTIPEWDQKFLKIEDEALFDLILASNFLDIKGLMYYGCKTVSNMAKGKTTAELREIFGINTDEQDAAEETAQKAAAEVA
The following text describes a protein:
Function:
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface.
Subcellular Localization:
Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Nucleus.
Sequence:
MAAVELEWIPETLYNTAISAVVDNYARSRRDIRSLPENIQFDVYYRLYQQGRLCQLGSEFCELEIFAKVLRAIDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQIGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQSYMDKLAKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITVGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLAREHFGAKHPKYSDTLLDYGFYLLNVDNICQSVAIYQTALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSVGNYEKVFEYHNILANWNRLRDRQFSVTDALEDVWLPYSRDVRKIHSRKLAYCEPRSSDRGELFNHLNWTSVYLTVWLKFKMWVDPSVGKCCVGERRPDLIKSRNF
The following text describes a protein:
Function:
ATP-dependent RNA helicase that associates with the RNA exosome complex. Required for proper rRNA biogenesis and development. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and also in the removal of rRNA maturation by-products.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGSVKRKSVEESSDSAPPQKVQREDDSTQIINEELVGCVHDVSFPENYVPLAPSVHNKPPAKDFPFTLDSFQSEAIKCLDNGESVMVSAHTSAGKTVVASYAIAMSLKENQRVIYTSPIKALSNQKYRDFKEEFSDVGLMTGDVTIDPNASCLVMTTEILRSMQYKGSEIMREVAWIIFDEVHYMRDSERGVVWEESIVMAPKNSRFVFLSATVPNAKEFADWVAKVHQQPCHIVYTDYRPTPLQHYVFPAGGNGLYLVVDEKSKFHEDSFQKSLNALVPTNESDKKRDNGKFQKGLVIGKLGEESDIFKLVKMIIQRQYDPVILFSFSKKECEALAMQMSKMVLNSDDEKDAVETIFASAIDMLSDDDKKLPQVSNILPILKRGIGVHHSGLLPILKEVIEILFQEGLIKCLFATETFSIGLNMPAKTVVFTNVRKFDGDKFRWLSSGEYIQMSGRAGRRGIDKRGICILMVDEKMEPAVAKSMLKGSADSLNSAFHLSYNMLLNQLRCEEGDPENLLRNSFFQFQADRAIPDLEKQIKSLEEERDSLVIEEEESLKNYYNLILQYKSLKKDIREIVFTPKYCLPFLLPNRAVCLDCTNDDEEPQSFSIEDQDTWGVIMKFNKVKSLSEDDDSRRPEDANYTVDVLTRCMVSKDGVGKKKVKAVPIKERGEPVVVTVPLSQIKSLSSAIMNIPKDLVPLEARENALKKVSELLSRHPDGIPLDPEVDMKIKSSSYKKTVRRLEALENLFEKHKIAKSPLITEKLKVLQMKEELIAKIKSLKKTVRSSTALAFKDELKARKRVLRRLGYITSDNVVELKGKVACEISSAEELTLTELMFSGIFKDAKVEELVSLLSCFVWRERLPDAAKPREELDLLFIQLQDTARRVAEVQLDCKVEIDVESFVQSFRPDIMEAVYAWAKGSKFYEVMEIARVFEGSLIRAIRRMEEVLQQLIVAAKSIGETQLEAKLEEAVSKIKRDIVFAASLYL
The following text describes a protein:
Function:
May play a key role in egg organization. May be a transcriptional regulator having a role in chromatin remodeling in concert with Hira, a histone chaperone. Involved in chromosome segregation by affecting kinetochores function in the first meiotic division.
Subcellular Localization:
Nucleus, nucleoplasm. Chromosome. Chromosome, centromere, kinetochore. Note=Abundant in the nucleoplasm. Only a fraction of the protein is associated with the chromosomes. Localizes to the chromosome arms and coexpresses with cid at the centromere.
Sequence:
MSKGGEHKRVTLTSIIQGDAGFSRFGSNILEPDAASAAPDNSSKPTTKTAKCIRIKLDLFETDSNKYPEFNYSRLLYLEKKKTKKLKQVSTTNGSASTDPFADNDDDVARIVKELEAKYGNSYATGRGKSKKDDYRDIGMGYDESDSFIDNTEAYDEIIPEEAETLEGGFYINCGALEFKNLTKKSYTTRTDAIIKMPERSRKRMVSSSSESSSSSSGDDDENDDGNNEEDDESDSEDDSEENDESDSEDDSESESLEDEDSAATAKSSSKYKDNHQAKRAKVIVTGKSKPSSSSLTSGKKPPTKPITTSSSSNSPRPSTVEISDTEDGQDPIQTQPSSQLQSLPQSQAQAQALKKVVKTTTVKDMLKAKRDSFLKSQSGTAAVKGVGNGELKCVSTDVSSSDSSDMESEHGRADRQAGQHGKDGQENLRTADTLLPTTLDADIVTAVNSFKEAVKSRDMCGKKFNLDVKLSPLLLRVYEAVLCTDRNERNMVFSHIEYQLQLPKYYMLRKGKQVRAKEEKRKSTIMLEKLRRAVAVVMPKAVANYETELRTFAEQAAADVNSELPPKMPRKKFQWTSELRHLLYDVYQARWTSYAFLAKRKESLEEFINWYLKEKVVELWPPGWMRLDELQREITRYKNAKLKAKEKPKAPPASASPKPVGVVSAPEQMPPASSYLKAVEDPRSRGNSDTDSATSASSNSLKRKLKEMPKQTSKPPKKKVAKQVPLQPQLTPHPQFQLAPAATAAVSIPAISNNNNHLPHLDTLLSMPSTSAQAAALNAAAVAAASTVLDLASPSRKIDLNTSNNFYNLITAASLAASGNPSPHSGDGQAKVIVGARPSPHVINLDDYQCTSDILQTSKQLAATTTVITAISKAAQTTSVARESSSESDGVEIVGVFPASKPQKKVQSKPKNKTQNRGRSSLGAVGQVNGSLGYSANNMYIYNSPRTLGPVYDLTDPHIMKTMSNLKEMEKQFIQAAFSPNSVKGASGGMGSSAPSTPTRQ
The following text describes a protein:
Function:
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell surface.
Sequence:
WSSKVLMSSGNEDTKSDLLLTSMDLKHLSVPTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTMHYRYKGSDNNTFQECSHYLFSKEITSGCQIQKEDIQLYQTFVVQLQDPQKPQRRAEQKLNLQNLVIPWAPENLTLYNLSESQVELRWKSRYIERCLQYLVQYRSNRDRSWTEQIVDHEPRFSLPSVDEQKLYPFRVRSRFNPICGSTQQWSKWSQPIHWGSHTAEENPSLFALEAVLIPVGTMGLIITLIFVYCWLERMPXIPXIKNLEIWLL
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPQLIPFYFMNQLTYGLLLITVLLILFSQFFLPMILRLYVSRLFISKL
The following text describes a protein:
Function:
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens.
Subcellular Localization:
Secreted.
Sequence:
MELCRYPGGENSKYKGSRAGTRRPVPAGEDCQTHPAARPTRARPASHAGTGARSHPTAGRGGRMARAALRLVLLLLVGDLAGSSRSQPGQLSKYRRPNCNKYNLPACTRDFNPVCGSDMSTYPNECALCLKIKEGGHDIKIIRDEPC
The following text describes a protein:
Function:
Mediates the anchoring of the endoplasmic reticulum to microtubules; High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.
Sequence:
MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTRRRRRESMAAAVVRVKRCQTDDPVEALLVSCKRLKAADGQATATVTAEDIREVFKFVGTVAKQGDNLPKHIKDSISKTRPHAKKQAKPVTSKRHEQNRDAFRVAQRASRYKVVASHRDIDVVLEREENKDTEKNGPKVAEGGEVEAGQLFGVFDAVEENSKEDEERKKKRAERKMQELSDPDAITCNSVRMIREKLTLSDSPAAPQQSPQFVYDIYYSDSLDPTHLQHIVEVTDCHQMELVHEDADDEGGDMYDDEDDSNDESNWRNDYPDEDEASSRDIDYYDPDYEWKDTFGDLSSDDDDYLGPRRMPGSVRSAESGAMARFKAHPLADLDDGYCYTVQDGGSDSDKGGDFTY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MAMEPNFFEQEANFESDGDILLKQKWNQISAPTKDSEKDAGGFDCNICFDSAQDPVVTLCGHLYCWPCIYKWLQVQTSSLDADQQHQNCPVCKANISSNSLVPLYGRGTSSDSESKNPHSDLVIPQRPPPSGLNSIISSSHQSQPLRENFFHSQSQSFHHQQYFPHGGYATLASSNLGGIAMTNFFNPMIGMFGEMVYARIFGSSDTGLVAYPYQASYPFFGNNNNLRMRRQEMQFDKSLSRVSIFLFCCLILCLLLF
The following text describes a protein:
Function:
Required for tolerance to DNA-damaging and cross-linking agents such as UVB irradiation, gamma-radiation, aphidicolin, ionizing radiation and hydroxyurea (HU), cisplatin (CDDP) and mitomycin C (MMC). Involved in cell-cycle G2/M arrest in response to DNA damage. Required for aluminum-dependent gene regulation and root growth inhibition in an ATR-dependent manner by halting cell cycle progression and triggering loss of the quiescent center (QC).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSGNDEEFNDEFLLAIDSIETTLKKADMYRPLPPPYLPTFLPAPPPSTKISSSLSHPMQLQSSAGQQRKQIQVPDPFLSYSPPRELSQRVVSGFNDALMDYSNSTVVTAAKPISPTTSNRRCDSEKDLEIDRLKKELERVSKQLLDVEQECSQLKKGKSKETESRNLCADDNRGQCSTVHASKRIDLEPDVATSSVNHRENDSRMALDDKRSFKTTGVQADVANHSDLSKKLLDIWRTSNYQDPRKNLISELLLACSTDLQILFSFMKISTPPQELNKQEAKTSSDRQSSKALESEKVYQLYSAVTKISYGFVNLKTLVEPLLDLCKAETAVLVHRSLRVLHVLLEHICGDEKRFEASWDANWHSLFKLMNQIASKRTEQDVKQEALSIMNIIVMSTDAYTARESFVSKEVFESISLLLRKEGGLHVRKEAIHLFYLLLNCPKLYDTFDSLHEEKNSSDTENDSEGNFFALEAFGKIFEGLADCLTSPRKTSEDLELCRNVIMILALAASSGNSGYELLSSHKLPQDSSFLMLILHLLVAEIDSESTEFHPKAEIFKARTLLMREILILLNRLVSGLSSSATILKELTTSRDMASLTVDAATRLSRKRNLLGKPESSVERMRNTEIMDLARIFKKRVFAFLGDNTI
The following text describes a protein:
Function:
Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) (By similarity).
Sequence:
MQSKEDFIEMRVPASAEYVSLIRLTLSGVFSRAGATYDDIEDAKIAVSEAVTNAVKHAYKENNNVGIINIYFEILEDKIKIVISDKGDSFDYETTKSKIGPYDKDENIDFLREGGLGLFLIESLMDEVTVYKESGVTISMTKYIKKEQVRNNGERVEIS