lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. In addition to ssRNA and dsRNA, binds dsDNA, but not ssDNA.
Subcellular Localization:
Nucleus.
Sequence:
MGEVKDNDAYEEELLDYEEEDEKAPEAINGKPGSETVKKGYVGIHSSGFRDFLLKPELLRAIVDSGFEHPSEGKVLYFFLFSFISSYRLSRDFYLRRISFASSVQHECIPQAILGMDVICQAKSGMGKTAVFVLSTLQQIEPVAGQVAALVLCHTRELAYQICHEFERFSRYLPDLKVAVFYGGVNIRTHKELLKNECPHIVVGTPGRILGLARDKDLGLKNVRHFILDECDKMLESLDMRKDVQDIFKMTPHDKQVMMFSATLSKEIRPVCKKFMQDPMEIYVDDEAKLTLHGLVQHYIKLGEMEKNRKLNDLLDALDFNQVVIFVKSVSRAAELNKLLVECNFPSICIHSGILTRYKGFKEGLKRILVATDLVGRGIDIERVNIVINYDMPDSADTYLHRVGRAGRFGTKGLAITFVSSASDSDVLNQVQESAGIRSGWLSLRMDGWMDDMIMSKISHCLNDWNKTSQSYITSKVKHISNELKLLKGTLAFQVIG
The following text describes a protein:
Function:
May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
Sequence:
METNILLESGTGEVEIIEFLVNNKHYAINVIKVKEVIEVDNVTKVPQSDPAIEGLILCREKIFPLIDLSYILGQKNTSKKKFKTIICEFNRVSVAFKIDEIVAVHRIGWDKILKPDDIAANPLVIGNILLKDKIILLLDFEKIVTDINPSTGISEERIVNVDYKDRSHIKVFLADDSSLIRKLLKDTLTKAGFKKLTIFDDGKQVLDKLLELVEKKGEDFTEDVQILITDIEMPQMDGHTLTRKVKEHPILKRLPVIIFSSLITKDLKHKGTSVGADEQLSKPDIGELVNIIDNYIE
The following text describes a protein:
Function:
Protein involved in bud formation. Functions redundantly with BOI1 to promote the fusion of secretory vesicles with the plasma membrane at sites of polarized growth. Acts as an abscission inhibitor during cytokinesis in response to chromatin bridges.
Miscellaneous:
MISCELLANEOUS: Present with 688 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud. Bud neck. Note=Localizes to the periphery of buds during much of the budding cycle and to necks late in the cell cycle.
Sequence:
MSNDREVPTLSQLNTTVSRDKDVSDTLSPDFDSKGSATGRDGGNFPMYIAINEYFKRMEDELDMKPGDKIKVITDDEEYKDGWYFGRNLRTNEEGLYPVVFTQKITVEKAPTLMRAKSTKRIYSPLTNEDPLLSSTFISENDSNSELPTPQPIETAASISRTANGKIERNLSLKNTMSDIDNALLEFKDDSIGPPDRFINSGRDEEHSITHETILSATDGLDVVESNSKPTTSSSTGFLNGDLENQATLINGIDTTKLNPVEAEFWSPEEITAYFIMEGYDVQSASRFQKHKISGKILLELELVHLKELDINSFGTRFEIFKEIEKIKEAIRTNGRSLNRASKTNNANIYNQLMPPANVDQRASYRGHVRKTSQSLEDLPSQQNFIPTPRNTRNSSASKHRPKSLVFDSQEANANIAPDVQIPQVVEEMAGNENLFVSPRRAPKPPSYPSPAQPPKSPLLNNTRTSPSPAQLYSWQSPTLSFSGPKRTSYIDQYSSSDSNFNSRSALPKNNQGGGKALSPIPSPTRNSVRNEDSEGKLTSSSKRNSVPYYGYAPESSSDRKSSCSSHEEEQFQETMNTFERPTSSIYADGSTIASISNDKLAHEKEGKKKPTRHSSSLSSKSKSDSRRNSSLKRSSSASRTSSFKKSSFMLSPFRQQFTDNAARSSSPEENPITSMPSEKNSSPIVDKKSSKKSRSKRRSVSAKEAEIFTETVKDDKNKRSASEAIKGETLKGKSLRQMTARPVAKKKQTSAFIEGLRSISVKEAMKDADFSGWMSKKGSGAMSTWKTRFFTLHGTRLSYFSSTTDTRERGLIDITAHRVVPAKEDDKLVSLYAASTGKGRYCFKLLPPQPGSKKGLTFTQPRTHYFAVDNKEEMRGWMAALIKTTIDIDTSVPIISSYTTPTVSLSKAQEMLAEAREETKLREQQMLENEEDEDQFLWDQQQLQQQQHDNNQGQADRTISASTQRTSDEDNTISTPNLSSANNTTIGSNGFSSPFLLASGLLSPGVARNSSMRGTEKKGKFSTEEDYFGDNSKHKTDKI
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSELNKEVVDLVWGRTSDGGVSASIFRRWTQGFVFSEYEPTALEQFEGGPCAVIAPVQAFLLKNILFNRESSNWRQLPEEEQKTALCSTLSEILESACASLSTGFCIVTWAKGHSPDTGKLTATEPESQVQTQDKPESSKPLQEQQPTYSVAEDLSFERFHSVLHKRTILSASDLREEVLSLYHSWRGCCGVLLFLYSVILTKGIENIRNEIQDPTEPLIDPVHGHGSQSLVNLLVTGHAVSNVWDGDRECSGMKLHGIHKQASVGFLTLMESLRYCKVGTFFKSPKFPIWILGSETHLSVFFTKEMSLVGPESPSEQARRVFQSFDPEDNGFIPESLLEDVMKALDLVSEPEYVSLVKTKLDPENLGVILLGPFLLEFFPDQDSGIPDSFPIYHYNGLKQSNYKEKVEYVEGTALVLGFEDPMVRTDDTPVKRCLQTKWPYIELLWTTDRSPSLN
The following text describes a protein:
Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence:
MSVAAQFEIEYLQYMDADGQLVRDDLPADAANPQQLLALFKRMLFVRTFDSKSIALQRTGKLGTYAASLGHEATHVGIGASMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGAALSFKLQGKAQVAVACCGDGGSSKTDFYAALNSAGAYTLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLIAVLEAMRQARARALAGDGGTVIEFLTYRLTDHTTADDARRYRGEDEVKQAWTREPMLRLRRYLTAQGLWDEAQEEAWKAECGARIDEEVNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVIALEARHG
The following text describes a protein:
Function:
An ATP-dependent DNA helicase which unwinds DNA in a 3'-5' direction. Requires between 2 and 5 single-stranded nucleotides on the 3'-end to initiate unwinding, is not active on blunt-ended DNA. Can target DNA replication, repair, and recombination intermediates; is active on forked, gapped and 3'-overhang DNA as well as 5'-flaps, Kappa joints, synthetic replication forks, and Holliday junctions. Prefers ATP over dATP, is not active with other nucleotides. Only unwinds short partial duplexes in vitro; SsbA enhances its activity on longer substrates. Has ss- and dsDNA-stimulated ATPase activity. Binds forked DNA strongly, ssDNA less well and dsDNA poorly. Required for DNA repair and intramolecular recombination; probably has overlapping function with RecS. It probably acts to help generate ssDNA from dsDNA breaks.
Subcellular Localization:
Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double-strand breaks. Another study finds it localized in tight foci to the chromosome replication center at mid-cell during most to all of the cell cycle.
Sequence:
MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGGGKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLNGLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEILFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKDRFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERFLNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLFSPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACGQCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLSTYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEALKAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKGVGEQKRAKYGRLFLQEIQAYARMTD
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MSQLYRDPWAKREAWRKHPVFSHRFFARNIFPGFGLGLGAFAVYLAIDTITHPSNIEKLKEDARKQTGRDH
The following text describes a protein:
Function:
Membrane-anchored myosin receptors that define a distinct, plant-specific transport vesicle compartment.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein.
Sequence:
MDSNLIFDQKVINGFAPVLTYAACEWFLILLMFIDALLSYLLVWFARYCRLQMPCFLCSKLLHPLHWRFLLCRNHRSEVSSYMSCQNHGNNLADCRGMCDDCLLSFTKMTGPNPDMNRLLLGKLGYDLLSRSHFAHPRSCSCCNKPWRTRHHTQRLIRLGSRGRNSSSKPNIPAPRHLTRRGSGGSLKKMRDHIATSGSEYVDVGSRDGMAHVGYTELKIHSDSESEFLFSDDDAFLHITDFNVEPSEKRTHKSRRRKSFDDKKMSNHKQPVLQDNQYKKIHVEDNETVESSMLGYNLENRTRQKQPVKAKEHDDVLSELITMSEARPFLLGSPRKYAAGVVTQNENEAEVSGSSSPSGGEFLSPSAENGASREIRIQEHDDSSDFSQNITSSAMEIEEFEAAIEQKESDHMDVSGSVANEPSSDEENEVEGDSKPLISNNMSDSLEQEQSGEEESEVNENNVAEEYFSNEEEDEVNGHTEPLTSKSESGSFAEEQSSEDEDGSNIYSVAKDHSSNEEDVDNEESEPMTSNNVTGVVKEEHSAKEEHGDHEETEPLTSLNISKEEPSLEHSDKDSLKITETRNTSNGSPELKHSASVESFVSISSDIEGESLVEVLKQQLEHGRKSLRDLNKEFEEERNASAIATNQAMAMITRLQEEKAALHMEALQYLRMMDEQAEHDMDALERANDVLADREKEIQDLEMELEYYRVKYPDEPREEILASMGILGNTEETNVTSPTDETSIKDSTDTKLTGSPSAEN
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLRCIQCNAAVYRIVQPENEVVEKCGTCGRRCDRYYEFSNCQKWISITLLEKPAWIHVLFNKKDIRATLFCTALLSRLIEAYVVRTSLVYGALRMLRSKGPVSNVSSVATLQLFRNVNPKIEPLMAYQDTLPNIFICACGEYLLCLLVTVIFALHSWRRGGSALWDVVLTWMTCVNLAYSAKLCFVVFLIWRIPIALVSLVDLISLLWAARGFSLVENRYPPLFTSVVVLICTAATRYLFRSVTQWSPQLLV
The following text describes a protein:
Function:
Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
Subcellular Localization:
Golgi apparatus, trans-Golgi network. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Sequence:
MAAAAAGPGPGSGTGDSPEGPEAEAPERRRKAHGMLKIYYGLSEGESAGRPAGSDPLDPTDLNGAHFDPEVYLDKLRRECPLAQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIRKMKNDFRKMEDEMDRLATNMAVITDFSARISATLQDRHERITKLAGVHALLRKLQFLFELPSCLTKCVELGAYGQAVRYQGRARAVLQQYQHLPSFRAIQDDCQVITARLAQQLRQRFREGGSGAPEQAECVELLLALGEPAEELCDEFLANARGRLEAELRSLEAELGPSPPAPDVLEFTDHGGSGFVGGLCQVASAYQELFAAQGAAGAEKLTAFAQELGGRYFALVERRLAQEQGSGDNSLLVRALDRFHRRLRAPGALLAAAGLAEAATEIVERVARERLGHHLQGLRAAFLGCLTDVRQALAAPRLAGKEGPGLAELLANVASSILSHIKASLAAVHLFTAKEVSFSNKPYFRGEFCSQGVREGLIVGFIRSMCQTAQSFCDSPGEKGGATPPALLLLLSRLCLDYETATISYILTLTDEQFLVQDQSPVTPVSTLCAEARETARRLLTHYVKVQGLVISQMLRKSVETRDWLSTLEPRNVRAVMKRVVEDTTAIDVQVGLLYEEGVRKAQSSDSSKRTFSVYSSSRQQGRYAPSYTPSAPMDTNLLSNIQKLFSERIDVFSPVEFNKVSVLTGIIKISLKTLLECVRLRTFGRFGLQQVQVDCHFLQLYLWRFVADEELVHLLLDEVVASAALRCPDPVPMEPSVVEVICERG
The following text describes a protein:
Function:
Involved in strigolactone (SL) signaling. Required for responses to SLs and the establishment of arbuscular mycorrhiza symbiosis in rice. Strigolactone-dependent association of D3 with D14 and D53 (a repressor of SL signaling) triggers D53 ubiquitination and degradation. Controls tillering by suppressing axillary bud activity. Tiller is a specialized grain-bearing branch that is formed on the unelongated basal internode and grows independently of the mother stem (culm) by means of its own adventitious roots.
Subcellular Localization:
Nucleus.
Sequence:
MAEEEEVEEGRSSSSAILDLPEPLLLHILSFLTDVRSRHRAALACGRMRAAERATRSELSLRGDPRSPGFLFLSHAFRFPALEHLDLSLVSPWGHPLLSSVPPCGGGGGGAPSASSSSGMNVYHPEAISEQNAFIAARLAGCFPAVTSLAVYCRDPTTLANLTPHWQASLRRVKLVRWHQRPPTLPDGADLEPLLETCAALRELDLSEFYCWTEDVVRALTTHPSATAALTHLDLGLAAATDGFKSSELGPIAASCPNLRKLVAPCLFNPRFSDCVGDDALLSLATSCPRLTVLRLSEPFEAAANIQREEAAITVAGLVAFFAALPALEDFTMDLQHNVLEAAPAMEALARRCPRIKFLTLGSFQGLCKASWLHLDGVAVCGGLESLYMKNCQDLTDASLAAIGRGCRRLAKFGIHGCDLVTSAGIRRLAFTLRPTLKEVTVLHCRLLHTAECLTALSPIRDRIESLEINCVWNTTEQPCSVANGTTTECDPEDDELGEVYESAAKKCRYMEFDDLGSWEMLRSLSLWFSAGQLLSPLISAGLDSCPVLEEISIKVEGDCRTCPRPAPRTIFGLSDLAGFPVLAKMKLDLSEAVGYALTAPTGQMDLSLWERFYLHGIESLQTLYELDYWPPQDKDVHHRSLTLPAVGLIQRCVGLRKLFIHGTTHEHFMTFFLSIPNLRDMQLREDYYPAPENDLMFTEMRAESWLRFEVQLNSRQIDD
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Sequence:
MERNNRKVLVGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKKYKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEEAVII
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Sequence:
MIGVLLPYVRKFQRSAESNDIADRFSYQYTSTLLGFSAIMMAASQYVGRPIQCWVPAQFTRTWEKYAETYCFIKGTYFLPGAFASEGEMSVTSPDDAVTATPQVGYYQWIPIVLVLQAFLFYLPSIIWRTFNESCELKIKELAAVSEASRKIKSNMSDDQVKATKFGRYFFKKLNFRNESPVFKETGSVVASGKFLPALYLLVKILYLANIVLQFWILTYFLETKSWMWGWQTFQDLMAGREWETTGIFPRVTMCDFSIMDLTSVHDHSIQCVIVINMLAEKVYVFFWFWLLFVGLLTVCSLAYWAVIYMLQSVGRNFIYSYLQQTPEFQTEQERGSFVPANFVDKCLTPDGVFISRLVQQNSGDLFTSIMLGEMFSLYRAREAEKAHKKDDDSALPASAPVDLQEDDDDDTPFPPPTKAVAETLTSDDEEEETDVDSPDTTATLPR
The following text describes a protein:
Function:
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol.
Sequence:
MFIISSKNMLQKAQHAGYAVPAFNIHNLETLQVVVETAAEMRSPLIVAGTPGTFSYAGMGNIVAIAGDLAREYNLPLAIHLDHHESLADIESKVMAGIRSVMIDGSHFPFEENVALVKSVVDFCHRYDTSVEAELGRLGGIEDDLVVDSKDALYTNPQQAREFVARTGIDSLAVAIGTAHGMYAAEPKLDFERLAEIRALVDIPLVLHGASGLPESDIRQAISLGVCKVNVATELKIAFSDALKEYFLQNPKANDPRHYMQPAKQAMKEVVRKVIHVCGCEGQL
The following text describes a protein:
Function:
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MAARVDFGDRELFQQLDAEADEAALDTRFGESDGEDCEELRQRLSESQEAVRALQAENRELRRKLNILTRPSGLTIDDAKVDGPLLQILSMNNNVSKQYHQEIEDFIVSLVQRYEEQQRAEPDKTYFSLKPQPSSFVLEEDPKVTSANMSKKIKEAFSVIGSVLYFTNFCLDKLGQPILNENPQLTDGWEIPKYQQVFTQILSLDGQEIQVKPKRPKPHCFNCGLEDHQMKDCPQPRNAARISEKRKQFMDACGEANNQNFQQRYHADEIDERFGRFKPGIISEELQDALGVTEKSLPPFIYRMRQLGYPPGWLKEAEMEKSGLTLYDGKASPGDEAEEEDDYNLSRRVTYDISKLINYPGFNMSTPNGVSDEWRLFGSVPLQPSQQKDIFAHYLSTYRSAGSKSNSKRLSSHQSSHRSKRQKGNNAEVSSADMEMDSDFEMVQNSPNYDGFQFQPPLPPGSPLNAIPPPLPRGTPPATPPNFTPPRPPMSVSSVLPRNASALATSNNSPAVRAEGSAMDEDTLTLEELEEQQRLIWAALEQADGTNSDSDLPGGTPLTGNSVSSSPSRAEPEVLLEEVTHKNVEVLEPELSDDMELKPKVEESENKATVIEKLIDLTEEHGDNKPISAEELVDLTKEEELDGVDSEKMAENCLSTSVNEVNHEKGGGDNPVAHGADMALKITSPIPDMSKFAAGITPFEFENMAESTGIYLRIRSVLKNSPRNQQKNKKSSL
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAKQHQKYEGVPVAEAAAVVFPVHTAVSDATTAFEDSSLPTATPVSNKHHNAEQEDGITVTWEKGELQPSEFRDKLFAVVFGLHLLALTSTAIVLTPAWLKEITDTASGSEEDEASDSSVNESSASPAFLATVFAIAIVAAPALSLFAMFVMQKNAKVLIKASLWASVTLCGFLAIICLVTVPPAGIVYGIITAFLFCYARRVEHKIPYAACNLRCGISVLTSNLGLVLIAFGVMIGLIGYTCLWAIAFGASMSKDEMWEDVQQVDEYSSDGKTLSAFGGTVAALFGLSFYWTHQALKNVVRVSVAGVTGTWWFSPSEAASFCSVAVRDSFFRSTTYSFGSICFGSLIVAVLHMIRSMLRSSANGNGNGGNVLRCIAVCILSYIEALVEYFNKWAFIYVGLYGYDYISAGKRVMSLFKTRGWDAIIADNLVNRLLGITSLTIGLLTGLCTLFVAFCFEENSAGMLGAGFLIGLVIGLVISGITFGLLSSAVDSIIVCYAEAPSEFNESHPVEAQDMHETWTSAWPSHNLNTLVVIGLGGGMGVV
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEIVFLMLLVLSLLLFPNGICKSLATGPPVVNIGSILQFDSTTGGVAAVAIHTALEDINSDPTVLNGTTLKVQMKDTNCFDGFLGMVQALQFMETDVIALIGPQCSTISHMISYVANELQVPLMSFASDATLSSIQFPFFVRTGPSDLYQMAAVAEVVDYNHWKIVTAIYIDNVYGRNGIAALDDALTLKRCKISYKVGFPSNAKRSDLINLLVSVSYMEPRVIVLHTGAEPGLKLFSVANQLNMMGNGYVWIATDWLSAYLDANSSVPAETISGLQGVLTLRPHIPNSKMKSNLVSKWGTQSKKYNYSDLRVNTYGFYVYDSVWAVARALDAFFDDGGRISFSNDLHDGIGGTLHLEAMSIFDMGSKLLEKIRKVNFSGISGQVQFDAVGNLIHPAYDIINVIGNGMRTIGFWSNYSGLLSTVSPEALYSKPPNISLADQHLYDVIWPGETAQRPRGWVFPSNAKQLKIGVPNRFSFKEIVTVDNATGSMKGYCIDVFTQALALLPYPVSYKFVPFGNGTENPNYDKLVQMIESNEFDAAIGDIAITMRRTVTFDFTQPFIETGLVILAPVKEHITSSWAFLQPFSLEMWCVTGLFFLIVGVVIWVLEHRINDDFRGSVCQQIITIFSFSFSTLFFAHRENTMSALGRGVLIIWLFVVLIIVSSYTASLTSILTVQQLDTSIKGIDDLKNSNDPIGFQVGSFAQDYMVKELNISRSRLRALGSPQEYAEALKIGPKEGGVMAIVDERPYVELFLSTYCKIAVAGTDFTSRGWGFAFPRDSPLQVDLSTAILSLSENGELQRIHSKWLNTGECTTDNSEFVDSNQLRLESFLGLFLICGVACVLALLLYFGIMLCKYLRHEPRKSLRRFISFVHGKEPPKNMERRSMSLPGSSTPTTPMGSFSSLDMERPARPVRNGSVIDMES
The following text describes a protein:
Function:
Major component of the type IV pilus (T4P) that plays a role in cell adhesion and motility. Not produced when grown under standard laboratory conditions.
Subcellular Localization:
Fimbrium. Membrane; Single-pass membrane protein.
Sequence:
MDKQRGFTLIELMVVIGIIAILSAIGIPAYQNYLRKAALTDMLQTFVPYRTAVELCALEHGGLDTCDGGSNGIPSPTTTRYVSAMSVAKGVVSLTGQESLNGLSVVMTPGWDNANGVTGWTRNCNIQSDSALQQACEDVFRFDDAN
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MPPAKKVGAGAATAPASSQQRSIASFFESGSKANTASKPTASAKNTKPSLNIPSVNESSPAVKRARNGSQSKSPPPADGNSESKLEVPVSPEMNGSKKASPSKKKVTDGVQTPSPTEAPCPAKSVTKFFGRRGKNATKAEGTADLPALESAKAGNGRGSPNRGDSVVGMRLRVWWPLDRVWYPGRVKAFNTENGTHVIAYDDGEDEIVTLSKEKLDWLDENEALEGLQKLAGARTKRRGLKADEDLPANGKRKKSSSEERTLDSPRMQQPEEDGGSPDKLARRNKRARTTADADSPVKLTVTADLFDEVDMAMPKEEEVKVRRRLKKKVSPTELEPKVEEVEMLDVEDLEVATTLAEHKLKESMVVGKRPGTSARRLQLEQLAALQHSSSEEEQEEEEDSPLNETLADLASKKIPSKTEKSLVSQKTAKEFFSEKLSGARAQKCSADTHPGRLKPVSEVKQDSAEKKVKSAPIDKQTLREALSGGLKGVTSLEKAEVCKSPQEIEAQRLARGELHAALVGEPAARFLGRVEEKFKFLGRNRKDASGRRPSDPNYDPRTVYLPQDFTKELSGGQLQWWEFKSKHMDKVLLFKVGKFYEMFEMDAHIGAQELDLQYMKGDQPHCGFPEKNYAVNAEKLAQKGYRVLIVEQTETPEQLEQRKRKTGSKDKVVRREVCAVITKGTLVDGDMLVARPDAAYLLSITERDFPFKEVSENGLPIARSKSEAQACIIGMCTVDTSTSHIMLGQFCDDMARTRLRGLLAEIRPVEVIKPHGLLTDATERALKDHTRQPLVTSLAPGKEFWDAKRSIREIMTIFASFKPAERASQNLQENGMAESEAVTENNCLPEALQRLVEADELGELALSSLGGALFYLQQALLDQTVLRLGRVDLLPGTDSFNMTKPSATCEGLIESNGGLSPIKRSEGIAGSDLEPYLLMDATALENLEIIENNRDGGTRGTLLGHLDYCVTPYGRRLLKQWLVRPLMRVDSIVKRQEAIHDLKTVASEAATSFRKELRSQPDMERFLSRLHAYSDESGRNAQKVVLYEDAAKKLLQELLATLRGCQALLQAVKSFEVVLPELSSDRLKQLISPDGGLSEMFSIIENFETAFDWDEAETTGRIVPSVEGVDAEFDEADSTVKSVSEKLSDYLSKQRKKFGNSSEINYVTVGKEAYQMEVPEELHAKVPASYEVRSSRKGYRRYWTPEIKELLQDLTAGEQQREQALQGILKGLVKRFCGHYQKWLFLIKSVAELDVLISLAEASEYAAPTCRPSFVSADPNSSASYQTPMISARSLRHPTLRLNGGGTVVPNDIELGGSHTSFMLLTGPNMGGKSTLIRQVCLAVILAQIGANVPAEQFEMSPVDKLFVRMGARDHIMAGQSTFLVEMSETAAMLRGATSNSLVALDELGRGTSTADGQAIAHAVMERLVSDVGCRGMFSTHYHRLSTHYSVTDSKVGLYHMSCTVGTEAGGLEEVTFLYKLAPGPCPKSYGVNVARLAGIPEPVLERAAARSAELESSWAEKDGSRTEDKLDVEVQGSTPSDSKFPTEVLAFIKKLLDDLDKGGNPDEFMSSQEAVHLLLKLNNKELL
The following text describes a protein:
Function:
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MNKKCTIIYATESGTSQEVAEKLSRDLVLYEIKPRLIDVTNYNKLELPMEKIVIFVLSTTGHGEVPDPMKPLWNFLLIKSLPSNSLANTKFAILGLGDSSYTTYNFAAKKLYQRLQSIGGTPLLRRGDADDQHDLGIDYEVEKWSQELISKLLTIYPLSPNFNINNIKNQLNKSKYNIKIDKINENNKEIKYEIPTQFYKSKLKVNKRITVEEWEQDVRHIELDISECKELQVPIKYQSGDVAYVLPKNPIKRVNEFIELLGLHSNWIIESIEPIDKEITQSPTLLKLPITIYDLVRCYFDIMGSPRRYFFELLSHFVTNPIEKERLEFFSSTEGQDDLRTYNQKEKRNYIDVLKEFPSIEIPFEYLFDLIPPIKPRPFSISSSSLLNPNTIHLTVGINTYTTPFRRLFRTGLCSQYFSSFLNDNDNNIVPIFIKESGARLPKSNEIPIIMVGPGTGCAIFRSFMQERLYFKNNSDNNNKLGDALFYFGCRSESKDYYYRDEFESNLEKGIISKLSVAFSRDGKDGKKVYVQQYIENDSDLIWDIINNRNGYFYISGSSGRMPKDVKQSLLTIIKSNLLKNNNNNNNNNNNNNNNNNNNNNNNNNDDENNIDEIVNNYFEKLEVEKRFITETW
The following text describes a protein:
Function:
Necessary for the transition from vegetative growth to stage 0 or stage II of sporulation, but sporulation subsequent to these stages is unaffected at 45 degrees Celsius. This ts effect is probably due solely to the E-79 mutation. Required for expression of early sporulation genes, further suggesting a role in the induction of sporulation. Depletion effects on sporulation can be partially suppressed by missense mutations in spo0A. Strains depleted for obg stop growing after about 3 hours and do not induce the sigma-B factor following ethanol stress. It cofractionates with the ribosome and upstream stress response regulators RsbR, RsbS and RsbT in size fractionation columns, suggesting the ribosome might serve as a possible mediator of the activity of obg and the stress induction of sigma-B. In glycerol gradients partially associates with ribosomes; this is stabilized by a nonhydrolyzable GTP-analog and to a lesser extent GTP and GDP; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Miscellaneous:
MISCELLANEOUS: Estimated to be present at 6000 copies per cell.
Subcellular Localization:
Cytoplasm. Note=Cofractionates with the ribosome and stress response regulators RsbR, RsbS and RsbT in size fractionation columns; binds to ribosomal protein L13.
Domain:
A mutant in the N-terminal obg domain (Asp-92) impairs growth and ribosome association but has no effect on sporulation or the general stress regulon (GSR). Replacing the last 22 amino acids has no effect on growth or ribosome association, but eliminates sporulation and reduces the GSR, showing for the first time that growth promotion and the GSR phenotypes are separable.
Sequence:
MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDVVFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQVIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLADVGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIEGAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERPQIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEFPLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKRFARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID
The following text describes a protein:
Function:
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
Sequence:
MNGPALQPSSASSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAVAPGTPGEAAETPARPGLAKKLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRRCTQLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSELGLPHLSSTGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLRHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
The following text describes a protein:
Function:
May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.
Miscellaneous:
MISCELLANEOUS: 'Sentan' means 'tip' in Japanese.
Subcellular Localization:
Cell projection, cilium. Note=Expressed exclusively at the cilium tip where it localizes between the cell membrane and peripheral A-subfibers.
Sequence:
MGGCMHSTQDKSLHLEGDPNPSAAPTSTCAPRKMPKRISISKQLASVKALRKCSDLEKAIATTALIFRNSSDSDGKLEKAIAKDLLQTQFRNFAEGQETKPKYREILSELDEHTENKLDFEDFMILLLSITVMSDLLQNIRNVKIMK
The following text describes a protein:
Function:
Glycine radical enzyme that catalyzes the dehydration of the non-proteinogenic amino acid trans-4-hydroxy-L-proline (Hyp) to produce delta(1)-pyrroline-5-carboxylate (P5C). Is involved in the anaerobic degradation of 4-hydroxyproline.
Sequence:
MARGTFERTKKLREESINAEPHISIERAVLMTEAYKKYEGSVEIPVLRALSFKHYIENRTLSINDGELIVGEKGDSPNGAPTYPEICCHTMEDLEVMHNRDIINFSVSEEARKIHKEEIIPFWKKRQTRDKIINAMTPEWLAAYEAGMFTEFMEQRAPGHTVCGDTIYKKGFLDLKKDIEARLKELDFLNDLDAYNKKADLEAMAIACDAMVILGKRYAEKARQMAEEETDEAKKKDLLLIAETCDVVPAHKPETYHQAIQMYWFVHIGVTTELNIWDAFTPGRLDQHLNPFYERDVENGILDRDRAQELLECLWVKFNNQPAPPKVGITLKESSTYTDFANINTGGINPDGQDGVNEVSYIILDVMDEMKLIQPSSNVQISKKTPQKFLKRACEISRKGWGQPAFYNTEAIVQELMEAGKTIEDARLGGTSGCVETGCFGKEAYVLTGYMNIPKILELTLNNGYDPISKKQIGIETGDPRNFQSYEELFEAFKKQLHYMIDIKIEGNAVIENICAKHMPCPLMSTIVDDCIEKGKDYQRGGARYNTRYIQGVGIGTITDSLTAIKYNVFDKKKFDMDTLLKALDANFEGYEAILNLVSNKTPKYGNDDDYADEIMQEIFNAYYNEVTGRPTVCGGEYRVDMLPTTCHIYFGEIMGASPNGRLCAKPVSEGISPEKGGDTNGPTAVIKSCAKMDHIKTGGTLLNQRFAPSVVQGEKGLDNMANLVRAYFNMDGHHIQFNVFDKNVLLEAQKNPQDYKDLIVRVAGYSDHFNNLSRTLQDEIIGRTEQTF