lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serine/threonine-protein kinase. Involved in regulating endoderm precursor cell movements during early gastrulation; activates apical myosin and thereby increases actomyosin contractility and tension in the apical cell cortex, probably as a result of recruitment of mrck-1 to the cortex by a combination of interaction with active cdc-42 and membrane binding. May phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation. Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation.
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Note=Enriched in the apical cell cortex specifically in the gastrulating endoderm precursor cells (EPCs), but not in the apical domain of other early embryonic interphase cells. Endoderm cell fate specification is necessary and sufficient for mrck-1 to localize apically. Forms parallel punctate bundles in dorsal and ventral epidermal cells.
Domain:
C-terminal region, including the diacylglycerol (DAG)-binding, PH and CNH domains, mediates interaction with membranes, with a preference for di-phosphorylated phosphoinositides (PIPs).
Sequence:
MAEPPPDDSAPVRLKTLENIYMDGPSKKPEALSFETLIDSLICLYDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFFEGIDWNTIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCLQETQPPRVLAAFTGNHLPFVGFSYTHGSLLSDARSLTDEIRAIAQRCQGDAELMEKSVDGFMVELENEKAELVQKLKEAQTIIAQHVAENPRSEEDRNYESTIAQLKDEIQILNKRLEDEALAQQQQKPKDEIVAESEKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIETEKIALIKKQEEVTIEARKSVETDDHLSEEVVAAKNTIASLQATNEERETEIKKLKQRMDEERASHTAQSEQEMKQLEAHYERAQKMLQDNVEQMNVENRGLRDEIEKLSQQMAALPRGGLNEQQLHEIFNWVSEEKATREEMENLTRKITGEVESLKNNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLKAELKNSQEQYLTSAARLDDTEKRMASLMREVAMLKQQKNIENSSDSAFSSTMGRGDLMISMNNDYEMSNSSLMRQEMISRQSTPSYENAILLHDHQVPKRVDDLRYKQKPMKTASGIFSPVSISAMERGHNFERMKIKTPTKCGHCTSILIGLDRQGLFCQSCQYACHVSCAERVSQSCPVPEEERRPLGIDPTRGVGTAYEGLVKTPRAGGVRKGWQTAYVVVCDFKLYLYDCTVDRQNKMQDVKNEIRLVLDMRDPDFTVCGVSEADVIHAQKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLFMAETEEEKRKWVVALSELKTLLRRSKLADRKAFLVKEVFDVTTLPSIRVAQCCAIIDRSKIVIGFSDHGLYCIEISRQLLIPVGGEKENKQRCVETVEYDEAEQLLMMIVGPAKDRHVRIVPSAALDGRDLKWIKVNDTKGCHLLAVGTNNPGGRAGFFAVAFKKSVTIFQIDRSEKRHKKWKDLAMPGTPQSIAIFNGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTSLQFLNQQTSYEAKLIVNVPGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFSENEVDIFNVTLAEWVQTINLRSAKPLSGDGILSTCLCNDSPIFVLLQNVLQDQDSIEVPVNLASGSTDGRKVTRRKFTFRTIGKDDRSASERRSHIQISTPSDFMHIVHMGPAPVMELQQNFIDLQSNHSHTSSDKDSLNRSVNND
The following text describes a protein:
Function:
DNA polymerase II participates in chromosomal DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSGDGRRRDRRDNRASKKRKLNRTPEEELEAKLGFDLFSEGEKRLGWLLTFASSSVDDEDSYKVYSCVDLYFVAQDGSSFKTKFRFRPYFYVATKDKMEIDVEAYLKRRYEGQIADVEIIEKEDLDLKNHLSGLRKSYLKLSFDTVQQLMDVKRDLMPTVERNKAKSDAAEAFLSVSTERREHRPQDFLDCITDVREYDVPYHVRFAIDNDIRCGQWYDVGVSSNNGVTLEKKTDLLQRAEVRICAFDIETTKLPLKFPDADYDLIMMISYMVDGQGYLIINRECVGDDIEDIEYTPKPEFEGCFKVTNAQNEIELLRLWFSHMQEVKPGIYVTYNGDFFDWPFLERRATHHGFKMSDELGFKCDMNQGECRARYACHLDCFAWVKRDSYLPQGSQGLKAVTKAKLGYDPLEVNPEDMVRFAKEKPQMMASYSVSDAVATYYLYTTYVHPFIFSLATIIPMSPDEVLRKGSGTLCEMLLMVQAYKANVICPNKHQSDPEKFYNNHLLESETYIGGHVECLESGVFRSDIPSSFTLEPSAYQQLINNLDRDLQYAITVEGKMDLEFVSNYDEVKNAIMEKLVKLRDAPIREECPLIYHLDVAAMYPNIILTNRLQPPSIVTEEVCTACDFNRPGKTCLRKLEWVWRGETFMAKKSDYYALKTQIESEFVDDSEKNNKALTHYSEKSSKSFLDLPKAEQQSRLKERLKKYCQKAYKRVLDKPVTELREAGICMRENPFYVDTVRSFRDRRYEYKGLNKVWKGKLSEAKASGNSMKIQEAQDMVVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLVEKIGKPLELDTDGIWCALPGSFPENFTFKTKDPKKKFTISYPCVMLNVDVAINNTNDQYQTLTDPIRKTYTTHSECSIEFEVDGPYKAMILPASKEEGILIKKRYAVFNDDGTLAELKGFEIKRRGELKLIKVFQAELFDKFLHGSTLEECYSAVASVANGWLDLLDNQGKDIADSELLDYISESSTMSKSLADYGQQKSCAVTTARRLADFLGDTMVKDKGLRCQYIVASEPKGTPVSERAVPVAIFETDAEVMKFYVRKWCKVSSDVGIRSIVDWSYYKQRLSSAIQKIITIPAAMQKVANPVPRVVHPDWLHKKVREKEDKFRQRKLVDAFKSMNRNEHSKRHDDSTRVPLVMDGDIVNELEDFGNKDRSSTCRPRPIIRHYEANNEQHSRKVNDQEDVEQQHNKPLQQNVYRSVDYQGWLQIKKRTWKDILERRKKQRLENSKKSDRVSSVLEQMNGKGNQGRSHVSSYLKRLEVDLTKRHWQIIQLVPSSLIGQFFAWVVVDGSMHKIHVSVPRVFYLNSRSAITEGFMGKRVNKTLPHGRHSYNLYEVSINEIQYGEASQKLAALLADPDVEGVYETKVPLEFNAIVQLGCVCKVDKTANKRSLQEPWNLSELHMKTTAECAYLEQSISFFYFYHSISEGRAIYIGYFPASKTMTVVVVNPYQNKDLSPVFLERHFHDACQSLSIEPPPRNGINFKVDYVAHVKDAEAVMQRAINGHSHGRENHMPMVAVIECPNVQLVKLGIRALDNFPCLSVPYNARDSQYQILGWQQVAAKTGMQRCAASVQWLNQRIALSRYAHVPLGNFELDWLIFIADIFFSRALHDNQQVLWISDDGLPDLGGINSEQNCFVDEVQQPALTYPGAYRNVTVELKIHHLAVNALLKYNLVNEMEGGTLLRFGHELDSGAFSTNDQNGFDESTSCVQAFRVLKQLIQRCLADAVTSGNVYADSILQHLYRWLCSPKSKLHDPALHQLLHKVMQKVFALLLAEFRKLGATIVFANFSKIIIDTGKYDLSRAKAYCDSLLRTIQSRDLFEWIELEPLQFWCSLLFMDQYNYGGIPTKSDEAVNNESQVDIISSWNIAEYLPKKIQDHFVFIVSQFMYIPWNYAKKQAQIRASLQNGDSCTPSINIGAAEAFESEITEFTKEQIGSYFTHKLLGIVHDIGLHMKGMNRLENNQSTSGLPPLTGDVHRGDASLEFIKHVCAVLALDQSVQHEVLVLRKNLLKYVDVKEFAPEAKFHGPCHSFILSNVICSYCNDCRDLDLCRDSALLTEEWRCAVPQCAQPYDREVMENALLQTVRQRERLYHLQDLVCTRCHQVKAAHLAEQCACAGSFRCKEDASEFREKMQIFLNIASRQKFQLLQECTSWILELR
The following text describes a protein:
Function:
Component of the transport system for branched-chain amino acids.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKKLTFKENMFIGSMLFGLFFGAGNLIFPIHLGQAAGSNVFIANLGFLITAIGLPFLGIIAIGISKTSGLFEIASRVNKTYAYIFTIALYLVIGPFFALPRLATTSFEIAFSPFLSPKQITLYLFIFSFVFFVIAWFFARKPSRILEYIGKFLNPVFLVLLAIILLFAFIHPLGGISDAPISKQYQSHALFNGFLDGYNTLDALASLAFGIIIVATIKKLGIENPTDIAKETIKSGTISIIMMGIIYTLLAIMGTLSIGHFKLSENGGIALAQITQYYLGNYGIVLLSLIVMVACLKTAIGLITAFSETFEHLFPKMNYLAIATVVSFISFLFANVGLTKIIMYSVPVLMFLYPLAIALIVLTLFSSKFHHSKLIYQCTIFFTMIAALVDGLKASPEFISSTSFSQTLINFSQKYLPLSDIGMGWVVLSLIGFIIGFIIYKIKHRKIPQA
The following text describes a protein:
Function:
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity).
Subcellular Localization:
Secreted.
Sequence:
AAETVVSGAELSLTANSGGEKTPPHAPGLLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPGHIAPYGLGGPFRSKRSLKELFPTKATEHRNRCQCANQKDKKCWNFCQAGKELSSQDTMQKGWDNHKKGKDCSKLGKKCISQQLGNGKK
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Miscellaneous:
MISCELLANEOUS: Present with 36900 molecules/cell in log phase SD medium; MISCELLANEOUS: There are 2 genes for eL24 in yeast.
Subcellular Localization:
Cytoplasm.
Sequence:
MKVEVDSFSGAKIYPGRGTLFVRGDSKIFRFQNSKSASLFKQRKNPRRIAWTVLFRKHHKKGITEEVAKKRSRKTVKAQRPITGASLDLIKERRSLKPEVRKANREEKLKANKEKKRAEKAARKAEKAKSAGVQGSKVSKQQAKGAFQKVAATSR
The following text describes a protein:
Function:
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy. The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins (By similarity). Acts as an upstream master regulator of the transition from G1 to S cell phase: ambra1a specifically recognizes and binds phosphorylated cyclin-D (ccnd1, ccnd2 and ccnd3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (By similarity). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (eloc) component of CRL5 complexes (By similarity). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (By similarity). In normal conditions, ambra1a is tethered to the cytoskeleton via interaction with dyneins light chains (By similarity). Upon autophagy induction, ambra1a is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (By similarity). Also acts as an activator of mitophagy (By similarity). Required for skeletal muscle development.
Subcellular Localization:
Endoplasmic reticulum. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome. Mitochondrion. Cytoplasm, cytosol. Nucleus. Cell junction, focal adhesion. Note=Localizes to the cytoskeleton in absence of autophagy induction. Upon autophagy induction, ambra1a relocalizes to the endoplasmic reticulum to enable autophagosome nucleation. Partially localizes at mitochondria in normal conditions.
Sequence:
MKLGQRNSVCILSSRERGAPGLASYRVLQQLVEEKTQRMKWQSQKVELPDSPRSTFLLAFSPDRSLMASTHVNHNIYITEVKSGKCVHSLVGHRRTPWCLTFHPIIPGLIASGCLDGEVRIWDLHGGSESWLTESNSAIASLAFHPTAQLLLIATNNEVHLWDWSRKEPFTVVKTASETERVRLVRFDPLGHYLLTAIVNPSNQPNDDDPEIPMDSVEMPHLRQRSFLQSQPARRTPILHNFLHILTSRNSVPQAGGAHSASTDGSSDSSGPYTLMCVQPLGMVCFCSRCSAARVPSPPDEDPSDSASLEAQAHTFSSARTEPLQMSRFSVESRAANRSSAFSSVYGGGSNMRNHSSSSGRRGVTGMAPVPHFRQHPPGREGGGRHPGADWTVSGLNGQSSSMTPQRTGASSVSLLSVLRQQETSFQSPVYTSASDRWGSTPGTSSSRHRPPEEEGQSSSSSIHSVLRCNLYRYFMDYEGTQDTVQPLDGSRQDQQTQEMLNNNMDPEQPGPSHYQSPYSGENPPHSHMNRCRVCHNLFTYNQGSRRWDRTGQPSSTERNTPWQPSSSAFHSVAPVSQSNEHLLEHRPIESTPNTPEPHVPFSQRTDTGQHEEQAVGLVFNQETGQLERVYRQSASSRSANISQGALNQEMPEDTPDNDYLRRLSPAAYYAQRMIQYLSRRDSVRQHSHRPPSRPRPLSSNPSSLSPSPVPNAESSEVDFEEFEENGSRYRTPRNARMSAPSLGRFVGTRRFLLPEFLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVPNCKIYNDASCDISADGQLLAVFIPSSQRGFPDEGILAVYSLAPHNLGEMLYSKRFGPNAISVSLSPMGRYVMVGLASRRILLHQISDHMVAQVFRLQQPHAGETSMRRVFDVVYPMAPDQRRHVSINSARWLPDPGLGLAYGTNKGDLVICRPVDVHSDGSSTSEHSERMFTINNGGGVGPSSSRSGDRAGSSRTDRRSRRDIGLMNGVGLQPQPPAASVTSQGTQTQNQRLQHAETQTDRDLPDDPQQPSTSQGSQVTDATESLDFETLPEDSGSEVVPETPPHSRPQEDEGSDPSEPSTDSTGQAEYVSRIRRLMAEGGMTAVVQREQSTTMASMGSFGNNIIVSHRIHRGSQTGADAQNRTRLSPIPGPSSGAPESLAAASYSRVLTNTLGFRGDTAQGIDLTEQERLHTSFFTPEFSPLFSSAVDATGPSSSIGADSVLEGEDFHDFASLPPSLLSSSPSLSPVNNSNYSNSDSSYLGDEYGR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MAEEANKDADISSLSLSLDPEIIGGQNNFLENNLQQIFQKIIQERGPFRDLKEEDLQKELQKESIKDESSAKSSETENVLEFATLDSKRNVNDTEVESMDSQAYKKELIEQIMIAQTECSLALDMTSLLLSKFKENSIETISPFLKSTVPPSSLQFSRSQPPESKESDATLAKCWKEKSLTSSCKFLFEAKERLTSVVETEHEYYTELVKVKEASWPLFNSQGSNHLSVQYSCLGGISLGLGLIRMKPESKSFEVQSSLLYSQAALKISILNKDRDEIGSSTWSWPSQNCNSVLLKDIYKLQEILFEMDIWNSLLQEAQSCGNQGVNFTGDEILVPISDDHVVRITLETSSKNTESGFTEDKKSNEDTSTNFVTIKQEKELLKCLCDTLNAIAHILFLKHCRKSDRRSQQPELYMAIDANAPLILRPLIFYYNLNQESLEFQRWLKQRDISFKFMPNYPWEKAKDFLELENSLSINRLSISWRIMVSNFEPAIFIQHTPTLHGTDKSVWRCKDQYSSNQFSSLKNVCQYIEHHINSLSRRSKKTE
The following text describes a protein:
Function:
DNA-dependent ATPase and probable 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for replication of kinetoplast minicircles. Involved in the segregation of minicircle progeny.
Subcellular Localization:
Mitochondrion. Note=Localizes to the antipodal sites flanking the kDNA disk.
Sequence:
MLRRLLQPAYNVALSGTSASTLPRKSASVGLVRTALMPVDYNAGALFCAMRFTSGTEKERKREPKRGSKRRSKATTTLSTPTDAQTSVTGAREGVALPQENMPDAIQPPATLEVRAAEVKEEPLAATPPQIQPQEETMGPIDGEPQLPLHSTLVYNALTGRMTSETSPSFLCLKSIGFGVNNKRQLYVEKPDVLRDLAQRMRKGTATLPSNWPVTIIRALGVILRNRRVEDPAEAIQQMMQVKINNLTHSRYAAVVNAVGDTDLQNILDGGLADEFVAVDLNEEQEKVINLALKGHLMYIGGSAGTGKTVLLRALCRRMQAEGLRVAMTATTGVAGCHIGGSTFHHAMGVSAQGDFVRKNHLLSYDAIIIDEVSMLPKKMFEEFDRVLREEAGAPDVPFGGVQIILCGDFLQLGVINEPPIIHSTTFREKFVKIRLETQVRQAKSSLFADALQQMRVGLVPESLTASVEQLPPGTMVPAAVNLLPTNKEVNTANEEELKRLPGDAVTLTPETGITALRCDTTATLLMRTTKDFKVEEFTKHLRGLLQATVDIPRASMVSAYRIYEDGHAVRVYLPQSESVAWRDAIRERFLEVAGLINDLDIGATVTEIIPSGDGLHTPEHEECLQRLMAKHPIAQPLTLKKGCRVLLRTNLTSRLVNGSIGTVVDFVECSMENIPVALRCERVNRCVDRYRIYCTMECGMPVPLLPVVKFHSGETIVVPPWEFLVGGNPITQYYSLSSVSLPLSLAYAFTVHKVQGLTLVGRVHLELSRMWPCEHLLYVAMSRVRNPEQLSMSSFDPKMVLANEACVKFDRELNTVDNLPSLAEYPVSSWKRCNDMVYHLRRQGTSLDRYLQNGAAKEGGSVPVQQLGLSGPVKGSLEHSMVVSRRLRKLIKQTERTIRMHERRQKKMAVEGAKQTDTTKASSGESLE
The following text describes a protein:
Function:
Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).
Sequence:
MNNSKIISKVLLSLSLFTVGASAFVIQDELMQKNHAKAEVSAEEIKKHEEKWNKYYGVNAFNLPKELFSKVDEKDRQKYPYNTIGNVFVKGQTSATGVLIGKNTVLTNRHIAKFANGDPSKVSFRPSINTDDNGNTETPYGEYEVKEILQEPFGAGVDLALIRLKPDQNGVSLGDKISPAKIGTSNDLKDGDKLELIGYPFDHKVNQMHRSEIELTTLSRGLRYYGFTVPGNSGSGIFNSNGELVGIHSSKVSHLDREHQINYGVGIGNYVKRIINEKNE
The following text describes a protein:
Function:
May be involved in recombination.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MWFKNLTLYRFNKPFSIETEALETALADFTFSPCGSQDVSKFGFSNALGKKGSTLVHSANNRHLICVTKEEKILPAQVIKESLEEKVAQIEDEENRKLAKKEKDALKDEIITSLLPRAFSRRSQTRALILPELEMILVDSSSATKAEELLALLRKALGSLPVIPLSFKAPIESQLTEWLKNGSAPLPFEMQDEAELKSAADEGGIVRFKQQDLKEDEVLAHLETGKEVHKLALHFGQSIALLLQSDASVKRLKFSEEFRAGNDELGNEDPMARLDADFALMGSELVALMHALVSALGGIEETQA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLKEHPGMAEDPQQQMGVPVVKLEKELPWGRAREDPSPETFRLRFRQFRYQEAAGPQEALRELQELCRQWLRPELHTKEQILELLVLEQFLTILPREFYAWMREHGPESGKALVAMVEDFTEGALEAKAVPCHVQGDQEETALCRGPWEPGVHLGPVEVKPEWGMPRGEGVQGLDQGTEEQLNQNPGDGMQAFQEQALPGVQAGLGLPAVSTRDQEMAAGFLTAGSQGLGPFKDMALAFPEEEWRHVTPAQIDCFGEYVDSQACGVSPPGVGSGEKEPKTQLADLKGALARVPSERFGEAALQSPELGRTCEQEAGSSVGSTLGPPPPPHGVAPLPRDLKTPSAFWKPFQCPECGKGFSRSSNLVRHQRTHEEEKSFGCVECGKGFTLREYLTKHQRTHLGKRPYVCGQCWKTFSQRHHLEVHQRSHTGEKPYQCGDCWKSFSRRQHLQVHRRTHTGEKPYTCECGKSFSRNANLAVHRRAHTGEKPYGCQVCGKRFSKGERLVRHQRIHTGEKPYCCPACGRSFNQRSILNRHQKTQHRQETPGQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MSERAGMLHFRLENHGDSMLDRMNSLRQQNKFCDVTVHIDETEVPGHRVVFAAGSPYLRDQFLLSNSHEVHISILQNSQAGKQLLLSCYTGILEFPEMELVNYLTAASFLQMSHVVERCTEALWKFIKPSQVSERKDDGQESSVDKRGAEQEGVEDTMQPESPASTPSDDSLDNDDIQIVKIESIGDVSSDKTKVCQSQYNSSEQTALHSLEPQHSLINSTVENRTGDTDNPLHSYTMSDNSSDNMGPPAKELFGPGNRIVDKTLQWHHQCPKCTRVFRHLENYANHLKMHKLFMCLLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKTFSQKCSLQDHLNLHSGDKPHKCNYCDMVFAHKPVLRKHLKQLHGKNSFDNAHERNTQDIGLDFDTFSNTHDSSEIISQSIHK
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cell projection.
Sequence:
MKKGVTYPLKIDTNLSTVSSSVNYNDIECVDIKSNGHYIVKFMYREWVGPLNLMTTQKTSIKISIDLKEQTVTCTHTDKKKTVYRWGEFPNKKETEQNKKEDNPVQYETFLSSNFNSEKYVNDLFTHKTDQQATVHLQYLENRKLGCIDHLKKDVYKNHLIFIGASKEIANSEVDMLDFRNLISDYGNVMSSLQNISISWDHYKVKKSGKIDFEPLSPATEPIQWLTTAPNELSVSIEQREFEVAVGLVEKINKIYESNPKVEIVMQTHPLKDQIENKVKILTDKLMNELRSPLLKANQIKDTISLLVRLSQNDKAKSIFLESRSHSINQAIKKIVFSGDLNRFIGELARVIFNSINSTCNDFTNSFPSYMNSGLVSWIIEELVLISDIFNRQVFILDNFYSISQAIRIIESHCEMMDQTGLSIGFYWNLLLQPHVEQLIVNYEIKIRDSMLHQLMDEKWNGVSNWDYEVKSQLNSLPSSLKNSGTPNSGGSGISNNNSNNNNNYQSPIINNNFNSGGGNKKIGLTFQQMHQDNLNNMEDIDQGRLKLTSSTIFLNTIIQKFAIDICQIITIDLIPVISQSLGSIFKDYMSYLKNEIQKEYLSDTQCLAIISDSVYIVDDLVSRIATRFEDATGEKLNNLTQLSSLLYSYFESIRDQYSTRKALELVDNSMNWEEQEYQVEEELDPFPKNFIVLSEALDRLAESIQTNVNVESVLPIASRIISEIVNIISNRFESTSNLVFGYGGLQHFILEMKYLATFAGKYPVEDSTFELINTMIRNHKEIYLNNTSDPKPLKTEEYFTSIIDNLVYQKAVYN
The following text describes a protein:
Function:
Possesses quercetin 3-O-glucosyltransferase activity in vitro. Involved in stress or defense responses.
Sequence:
MNREVSERIHILFFPFMAQGHMIPILDMAKLFSRRGAKSTLLTTPINAKIFEKPIEAFKNQNPDLEIGIKIFNFPCVELGLPEGCENADFINSYQKSDSGDLFLKFLFSTKYMKQQLESFIETTKPSALVADMFFPWATESAEKLGVPRLVFHGTSFFSLCCSYNMRIHKPHKKVATSSTPFVIPGLPGDIVITEDQANVAKEETPMGKFMKEVRESETNSFGVLVNSFYELESAYADFYRSFVAKRAWHIGPLSLSNRELGEKARRGKKANIDEQECLKWLDSKTPGSVVYLSFGSGTNFTNDQLLEIAFGLEGSGQSFIWVVRKNENQGDNEEWLPEGFKERTTGKGLIIPGWAPQVLILDHKAIGGFVTHCGWNSAIEGIAAGLPMVTWPMGAEQFYNEKLLTKVLRIGVNVGATELVKKGKLISRAQVEKAVREVIGGEKAEERRLWAKKLGEMAKAAVEEGGSSYNDVNKFMEELNGRK
The following text describes a protein:
Function:
Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHC II trafficking MARCHF8. Also inhibits MARCHF1 association with MHC II and ubiquitination of MHCII (By similarity). In addition, acts as an important modulator of protective responses against acute infections.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MSQGLQLLFLGCACSLAPAMAMREVTVACSETADLPCTAPWDPQLSYAVSWAKVSESGTESVELPESKQNSSFEAPRRRAYSLTIQNTTICSSGTYRCALQELGGQRNLSGTVVLKVTGCPKEATESTFRKYRAEAVLLFSLVVFYLTLIIFTCKFARLQSIFPDISKPGTEQAFLPVTSPSKHLGPVTLPKTETV
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MVVSPPIKLLIIGITTRLAYYLWMVMSSSILPPYDLQTYLLSENVSPYLAPFASWDGVHFLSIAMHGYVHEHQHAFFPLYPLTIRLFSFICSTSGFNEANIYIVFGLFISLVSFLVSLLTLYAITKNLMGEVYAFKTGVLFCFAPASVFLTSVYTESYYGCFSLLACYYLLSKNNILLSCVFFALASFIRSNGLINMGFVLYYFINTMIPFSSFPHVQKRISVKHIINTILLTISNLGPFMIYVYLASSQFCNLDPLPPYCKSKFPNVYSYNQSRYWNQGFLKYWRVKEIPNFLLCAPAAIISLVSTVVYLKKYFERHPLFHSIVKTSEHSNTKKFMLQNDALVYVVHLFVLVVFGLFCMHTQVITRFISACPAFYWGLLWLTEQKQFGIIRYLPIFYSTFFTFFGGVMFGSFYPWT
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.
Miscellaneous:
MISCELLANEOUS: Present with 1790 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MLKIKALFSKKKPDQADLSQESKKPFKGKTRSSGTNNKDVSQITSSPKKSFQDKNIVQYPSVVADDHHMKSLTDELVTTIDSDSSPSDNITTENVETVTSVPAIDVHESSEGQLSSDPLISDESLSEQSEIISDIQDDSTDDDNMEDEIPEKSFLEQKELIGYKLINKIGEGAFSKVFRAIPAKNSSNEFLTKNYKAVAIKVIKKADLSSINGDHRKKDKGKDSTKTSSRDQVLKEVALHKTVSAGCSQIVAFIDFQETDSYYYIIQELLTGGEIFGEIVRLTYFSEDLSRHVIKQLALAVKHMHSLGVVHRDIKPENLLFEPIEFTRSIKPKLRKSDDPQTKADEGIFTPGVGGGGIGIVKLADFGLSKQIFSKNTKTPCGTVGYTAPEVVKDEHYSMKVDMWGIGCVLYTMLCGFPPFYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVAKLLELEPSKRYDIDQFLDDPWLNTFDCLPKEGESSQKKAGTSERRHPHKKQFQLFQRDSSLLFSPAAVAMRDAFDIGNAVKRTEEDRMGTRGGLGSLAEDEELEDSYSGAQGDEQLEQNMFQLTLDTSTILQRRKKVQENDVGPTIPISATIRE
The following text describes a protein:
Function:
Involved in the curing of prion [URE3]. Nuclear localization of this protein may suggest a role in transcription regulation, so it might exert an effect on [URE3] through known prion-curing chaperones or BTN2.
Subcellular Localization:
Nucleus.
Sequence:
MAAACICQPNLLEINVSDGPLDMIRKKRKIQQPQLRPPLRENKCQPHFSVRKVNQSYIISLHKEITCQLIAEIVKQKLSRIWEKVYIPSYELISDKDGNQIYVEQSVDENRLTSEIMEKLDPNNIDIEAIEILFDDYHLELSRLTNGIIISSANDHFYREFSFNNIIDDNFKICGTSMSADSFDKIYGVMWIEVPFNGNGLQNDSAVNRVSTSHNQIEELNDIEQEIRAFNISRSNQESIIKKEVSRRLNGR
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MLVLKLLLWSIISGLSLAEQVWRNSNAIRTIDLRSTYTKTLTSLIIVNEGDEPQNTYRYFQQTSPGESVLSLSVSIKEEEKKGTNPIKVNNNVYDIPLQPPVKPGESRTLLIQAGLDGGVRPLPAAVDQDEEQYLVYLTTLYLDSPYTTDLQRTRLILPSAKIDTYTTYNIDGAELPNRVGNTLVYESRETITGEDNDLGEIYVRYEHTVPIPRGADLYVQIDMHEYRKMLEVSERVVFENHAAKLKSNFDRAKWYMGNFYNPVSTAINRVVYSLPRNSKDVYYTDEVGNITTSHMRVEPHQTWIELNPRYPVFGGWNYLFQLDWKMPYEEFRSSKNRREYLDIPLAWSPGDMIYEKAVWSYVFPEGATNIEIEMPVEISNSNVTKIHKFLDTLGRQVFTYEALNVTDGVPSDIVHISYEYNSSAFFLRIAIITTLLILLAAAAYMIWAP
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAKSLPLNSRSKTTALKQPRELFSYARDIDGKYVYDDPENSLSYYYLPDSTIDTGIDLQGGYSKFKKIPDEQNLADFNSLLKAIIKYETSEGKKISSDIITFREIMTKILSLPYNLTDPIDLYVVPFDGQLFIKSDDELDMKRRKEQEVRMKQTNTVERYDYMKRCEYVGYKFETIATIPKPWSQVSRSQIENRNKKVVNNYEQYLSVIRTGIGNVKLVLAGEIDCCWDYLPDEQNKKLNHYVELKTSRIIENNSQVVSFEQKLFKAWCQCFLMGVTKIIYGFRDNNLILKNVELFNTEEIPILIKNNPLTNAATEKKINCTNALKWYGAVVDWLNTTVDKKDETKSYRLKYDPVRKSFTLSETESETNEKLRNGELLTPEFTEWRQSLKK
The following text describes a protein:
Function:
Catalyzes the NADP dependent reduction of L-sorbose to D-glucitol. Can also convert fructose to mannitol, but less efficiently.
Sequence:
MSEEIISFTNPALGPLPTKAPQLPSNVLDLFSLKGKVASVTGSSGGIGWAVAEAFAQAGADVAIWYNSKPADAKAEYLTEKYGVKAKAYKCNVTDPNDVSKVINEIEKDFGTIDIFVANAGVAWTDGPEIDVQGYDQWKKIVDCDLNGVYYCAHTVGQIFKKNKSGSLIITSSMSGTIVNIPQLQAPYNAAKAACTHLAKSLSVEWASFGARVNSISPGYILTDIADFADPEMKKKWWQLTPLGREGLPQELVGAYLYLASNASTYTTGSNIAVDGGYTCP
The following text describes a protein:
Function:
May act as a soluble regulator of keratinocyte differentiation.
Subcellular Localization:
Secreted.
Sequence:
MKLQGSLACLLLALCLGGGAANPLHSGGEGTGASAAHGAGDAISHGIGEAVGQGAKEAASSGIQNALGQGHGEEGGSTLMGSRGDVFEHRLGEAARSLGNAGNEIGRQAEDIIRQGVDAVHNAGSWGTSGGHGAYGSQGGAGVQGNPGPQGTPWASGGNYGTNSLGGSVGQGGNGGPLDYETNAQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFSNSGGSSNDGSRGSQGSHGSNGQGSSGRGGGQGNSDNNGSSSSSSGSNSGNSNSGNSGNSNSGNSGNSGSGSRDIETSNFDEGYSVSRGTGSRGGSGGSGGSGGSGGSGGSGGGNKPECNNPGNDVRMAGGSGSQGHGSNGGNIQKEAVNGLNTMNSDASTLPFNIDNFWENLKSKTRFINWDAINKGHAPSPSTRALLYFRKLWENFKRSTPFFNWKQIEGSDLSSLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSSSASRAQPGLLKWLKFW