lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity.
Miscellaneous:
MISCELLANEOUS: Present with 166 molecules/cell in log phase SD medium; MISCELLANEOUS: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDALREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLSNCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDIDLQDA
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Sequence:
MIMKVKLLEYTPNAEKLIASAAKLCYSSSGIENLQNNLDKEKVDKFLNMLMSYGHESPIEHVSFTFGIEGVSRSLTHQLVRHRIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIKTMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARYVFPNACTSKIIVTMNARSLMNFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVREKYNVKLYKESK
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, nbn acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits mre11 and rad50 components of the MRN complex to DSBs in response to DNA damage. Promotes the recruitment of PI3/PI4-kinase family members atm, atr, and probably DNA-PKcs to the DNA damage sites, activating their functions. Mediates the recruitment of phosphorylated rbbp8/CtIP to DSBs, leading to cooperation between the MRN complex and rbbp8/CtIP to initiate end resection.
Subcellular Localization:
Chromosome, telomere. Nucleus, PML body.
Sequence:
MWRLVAERAGGDTYYILTGTDYVVGRKNCAILIPDDQSISRCHATLSVSYPSASLSQTNAVSVLTIKDSSKYGTTVSGERMQPAVPRSLKPSDEVIFGCFHSKYRVEYEPLVVCSSCLDNTEKNSLKQNLIHLGGHMLNNWTEKCTHLVMTSIKVTIKTICALICCKPIIKPDYFRELINAIQQKRPLPEYRSFIPPIDEPSLNPESLDLSENVKRKSIFKDKVFLFLNTKQYMKLSPAVLLGGGKAHLLESLTDTSVLENSTTCVIDVAMTETQLSETQSTQPWISCTLDLLHSKGLRAIPEAEIGLAVINVSTEIYCNPRRLAASGNEAGNNDFSFPKATVKETSKRTQVLSSTLSQGMTVDETVLPAPALNMTAYVADTEPQDQTDTGMNISGVREVKETPGSSSSHSRSRSCIEKEPKSGSSNDLRQALFQGDKTETRNKNNHPLLPIKPSARDVGKTSQKLQPTKKIDSYFQSLAKKRDRDEDEKEVSSAKLARVEPVSSQNTEEQFRPITEALDKEEDNFDSDLDMELAMSCDQILMGSNKVIPEDPTMKKRKVPDDHVVEESDIDSDEGISANAEQNDTESNLNKTKKRKLDSKIEGVKELTIKPHEIGTKAQAKTNTPEMEPSVKKEIEVKTEFEVKKEPESPQKETKCVPDLAGESDALPSRLLLTEFKSLVVTRPVRNNNTTSNSSNENCQNFKKFKKVAYPGAGSFPHIIGGSDLIAHDRKRNAELEQWLRQEVEEQTQQAKEESLAEDLFRYNPKSNKRRR
The following text describes a protein:
Function:
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Sequence:
MDQAKLARMQASVRIGGKGTPRRKVKKVHKTSGADDKKLQATLKKMNVQPIQAIEEVNMFKEDGNVIHFAAPKEERALTVGCEIKVHASVPSNTFALYGNGEEKELTELVPGILNQLGPDSLASLRKLAESYQNMQKNQAGEKKDDDEDDIPDLVEGENFEKSVD
The following text describes a protein:
Function:
DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. With HSP90, is required for the modulation of the chaperone levels in response to growth temperature, rather than the activation of acute responses to sudden thermal transitions. Activated during infection and contributes to full virulence.
Subcellular Localization:
Nucleus.
Sequence:
MIMNMTTDYRDPLLDLFGTESNSGNETSSPSDIPVINRSGTFNQQQFSPLLTQQSLYNTPNSGSTPNIFDPNYTQMQEEQTSPSSNKLQPEDPPRKKRNTRSQTKIHQQSEGDEYNSNDYKDSIDLDKPPVVEPSPPFFVESDTTPEFVIPTPTSEQQQQQHHELIAQDYQRSNNSNQFGNLTHYEPNLPPLPPLSESILPQTNTFHPLVLPHDPRHAITAGPANNSQQQQQQQQQDSSIPSDGISSKIQQLHAPSLSNNQSASQRKKKESSGPKTRPAFVMKIWSMVNDPANHEYIRWNDDGKTFQVFHREDFMKVILPKYFKHNNFASFVRQLNMYGWHKVQDVANGTLNQNSDKNGQDEIWQFENPNFIKDREDLLDKIVRNKSSSNQDDVSGVSFNGINNSANLSLILQELETIKMNQYVISEDLRRVRQDNKMLWQENYLNRERNQVQGRTLDKILKFLSVVYGNNANKILNGHGFADFNDSNNIMTQYRPSPMGSPLLSRPQTQPPPSNSRFARDNNQTAQPTYESPLSTSDTNNNNNNTFEYQQAVNRPRLMLTNRAHSRRPSMSRTKSTPEGSIEEIIRSYSNDKAAESNVNRMYEQLVGHQPGATTNNNNHSSSTAISAPSPRHSFLQELNLPGTPRNLDDLEKHINKEGQSIQQVQDWIDKLAQEQHEKQQQQQGNDDDDDFDVNEFLKDATTTPSSNVPNGGHYNNGNISFVGSPIAMTPGSNVSSNINDSDGNEKKSKKRSIEEVSDH
The following text describes a protein:
Function:
This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.
Miscellaneous:
MISCELLANEOUS: The amino acid at position p2' (17) appears to determine the specificity of the inhibition of domain I. Inhibitors with methionine in this position interact weakly with chymotrypsin and elastase; those with leucine interact strongly.
Subcellular Localization:
Secreted.
Sequence:
SKKEDSCQLDHAQGPCLGMISRYFYNGTSMACETFQYGGCLGNGNNFASQKECLQTCRTVAACNLPIVQGPCRAFIRLWAFDAAQGKCVLFTYGGCRGNGNKFYSQKECKEYCGIPGDGDEELLR
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MRYLKKNKKQKDGRDDMLSEKDCIRVFDGRNGEWLARVRVSPQHQEDVNSIDMGKRTKRKREITSLMAECIVQLSLQTCQDDAPWVLFVPLKKQPRMKLMIEKCTELGVGRMIPVVSDRSAWMVSSNNDDLDVLYGGNSDEENVFDKLELQAIEAAEQCERLSIPIITNEVSLGVQDDEANDRVWSVESLIEEWCRGWEERDVTADKRRLLVCRERGNDGTEGKVLPVIQALYDNPRVAFLVGPEGGWSPEEEAKFDSTCTKYQGKDSPVQCISLGSSVLRAETACMMAVGAWALVHDS
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MPDMLEQTNALLAALKKPSTNVDQRLQLFSNVKSNIKHNRVPEECQAPIFECIRIAISATTSATLVSTGFSTLSHFIKRLQLQRETAVITSQSSKLCALLLEKLGDARESHRSASLQILADLHPLCPLEVETLIHNAMKGTNARAKDTSMTWVVKMNQTENLPFRAYSAQMIANLEDADAGVRDTAKHAVVDLFTSAPEHAKANLKKQLVSTNVRKAIATYITAHLDGAATGGAHEEMPPPPPAVRERPLPTQRAQTLQPDHGIADALAAEQPPPTEAVTMDPIHIYTQRELEDIFRDMAPPFEGRESEGNWLARDKNTTKLRRILMGNAPAEFPGAFVAGIKSLLEGILKVANTLRTTMSTNGCQLVQELAKTLRHAIDPWVEILLQCFIKMCAATKNIAAQNGNVTVEAIISNVSYNNRILQHVSFAATNALRASWVKTLIRKHKAHVEHSGGLDTLEKIIRKGVTDANPKVREAYRSTYWTFALVWPQRAEAMFETLEKREKTALEKDPNNPNASLASSQSSAVSSFSKSVGAGAARNALKEKIAEQRRAKMAASKVPERPMSAAATYSPVKSASTKSLSARTASTASTASNGPARPPSAMSGESTKSALKNSSGTGSLMSGTVRRPIRRPELNRPATADPYAVRRAGNGKTTPSMTPEKTPAVTTTKKSVAPKSSVRPRAQTQNSPNVSPIRSRSRLGQSTTVQKTASASSRQASPAPSASKDEDLELTIVKPFVRSQSHHDPGTIPFRQRNGLDKSAVFDNETVLSGDEDNFTMVIPNLARPTAQSIHHTPPKTHSPSHLSAPSPRASMLRSPKSMGDINGFGFRSSTRSPRVRSPDRPSTRGTDAQEGVQVFEDPFVGDEPAAVEHEVEKPVLGELPINEKNIERRPSNESISSDTVMGNASEDRPRGHHKTTSTGSVLYSESNDTNNAEVLKNRQLLASGIKKIESRTVESHMFRRMQDMIRSNHEIWGANDENFGCLLLACLDFLEVPTEELKTTPIKVANLKVQALATIRAMLSLYRKETAKYFSRVLCTVLQTKAQYENTSHIAIDLETTAEEIVRYGQTSDCLNAVLALIEDLPSSTPTSSPSSKSSLTSLPGAGQTRTATMALSTLAALIQISGAKNITLSPDQTSRLGKLAVRCMDDQDADVRKSNIEFCIALHERIAAPAGEQENDGFWRAVAGAREQHLNLLTYYLAKRRAA
The following text describes a protein:
Function:
Transcriptional regulator. Acts as a transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide.
Subcellular Localization:
Nucleus.
Sequence:
MEANWTAFLFQAHEASHHQQQAAQNSLLPLLSSAVEPPDQKPLLPIPITQKPQAAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHQSCHTGIKLVSRAKKTPTTVVPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTAMPVPQSVKKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFNITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITSPLAMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW
The following text describes a protein:
Function:
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MIMMGHFALLVFLAFASMQLLCIAADHDAAIFYDSFEEPFNGRWIVSDKDDYKGIWEHSKSEGHDDYGLLVTEKARKYAIVKELEEPVNLRDGTTVLQYEARFQNGLECGGAYLKYLRPQEAGWKPKEFDNGSPYSIMFGPDICGLTNKVHFILKQKNPKSGEYVEHHLIDPPRVPSDKLSHVYTAILKPDNEISILIDGEVKKKGNFLSAQDFDPPIIPAKTIPDPNEKKPEDWDDRVRIPDPNAVKPDDWDENAPMEIEDMEAVKPEGWLDDESEEIDDPEATKPEDWDDEEDGVWEAPKIDNPKCQTASGCGEWKRPMKRNPAFKGIWNPPLVDNPNYKGIWKPRDIPNPNYFELDKPYFDPIAAIGIEIWTMQEGILFDNILIAKDENVAESYRDTTWKPKFVVEKEKQKAEEEAAGSDDLGGFQKTVFDVLYKFADIPFLSKYKLQILDFIEKAEKQPNLTIGVLVSIVVVILTAIFMLIFSGKKQQPRVEKKTEVAADTSNDQGSSGEKPAEEEKEEEKENETGGAAPRQRRRDT
The following text describes a protein:
Function:
Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDRNVYEACSNIIKEFGTHVVSADEVLAEKIDNAVPIPFKTREEIDADVEKDRNEGVFEGNIIPDIDLRVVHYYATQLCLNKYPHLINAFDETSLITLGLLIEKWVKDYLTSIQTEQGRQSKVIGKGPCEFISKHIDYRHAPGNI
The following text describes a protein:
Function:
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Sequence:
MELSCRYLITQILRKLEVYENDPTVKLLILKGQGKVFCSGGDVVAMVLSIYGGHWSFGESFYRKQITLDYLFATSEKTLVSLINGIVMGGGVGLSMNSRFRVVTENTVFAMPEAQMGHFPDVGVSYFLSRLPGFFGEYLGLTGAQLNGTEMLACGLATHFVLSKDLLLLETALSEAASDTSTIPKVINRFARKTFLKQDSAFMRLEIINKCFSAKTVEEILLLLQNEVANGSDAWIIEAISSMKSASPTSLKITLRSIREARMQELEDCLVRDYFICYHIIQGIHSIDFLEGSRTKLFEKGKKPKWEPSKLELVSDEMVDHYFAKVEAPDIEHLRLPARKNIPKALESKL
The following text describes a protein:
Function:
Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.
Sequence:
MLAGPSKDAGKFSSVKDQLQLPQKIPNSEESEKKDTPLDLAADRTLFIDFANRQLTAIPSQILEMKELEEVHLEKNLIETISTDICHLKNVKVLYLNDNNIEALCEELGELRNLLCLDLSSNPLNSSSLHVISQFRALRELRLYKVSLDELPAQICKNLHHLELLGLSFNNLSFLPKEIVNHTQLKEIYLQNNKFESFPRDLCLLFNLEIIDLEQNRINAIPEDIGSLTRLMKFFMASNHLLSVPDSVSHCKKMTVLDVSYNCLRSLPQNFQELTEMTEVGLSGNYLEKMPRQVCKWTSLQLLYMNNNGLRTLRRSFKRLTSVRFLDLSQNVFDCFPEEICVLKNLEILSLDDNKICQLPPEVASLSKLKSLGLTGNEFTAFPEEVLLLQSLEKLYLGQDQGIKLTALPESIKKLQNLKELYVENNHLEYLPAALGSLNNLEILDCHNNLLKQLPDAICQAQGLQKLFLQNNQLSQLPENLDSLQKLKVLLLGGNPMIDPPNEVCRQDNATIWKYLQEKRYKTRMATKIQAWWRGLMVRKGLGPYADLQKSVKKGKKGSTKDKKAKKKEKEKPGTVSKGKKN
The following text describes a protein:
Function:
Catalyzes the transamination reaction between L-asparagine and 2-oxoglutarate to produce L-glutamate and 2-oxosuccinamate. Is not active with pyruvate as amine acceptor. May also use other amino acids as substrates.
Sequence:
MTKLSRRVLEMEESVTLATSARAKTLKAQGRDVLELSLGQPDFVTPKNIQEAAMKSIRDGRASFYTIASGLPELKDAISQYFEKFYGYSVERKQIVVGTGAKFILYALFAAVINPKDEVIIPTPFWVSYADQIKMNDGVPVFIRTSEENHFKATVEQLEAARTNKTKMIVLNSPSNPTGMIYSKKELEAIGNWAVKHDILILSDDIYGRLVYNGARFTPISTISQPICQQTIVINGVSKTYSMTGWRVGYAVGDPEIIGAMSKIVSQTTSNLTTAAQYAAIEALIGNQDTVEVMRQAFEERLNTIYPLLAKVPGFHVVKPEGAFYFFPNVKKAMEMKGYTDVTEFTTALLEETGVALVTGAGFGAPENVRLSYATDMVTLKEAINRIQAFMEK
The following text describes a protein:
Function:
May be involved in head or eye development; development of the clypeolabrum and several head sensory organs.
Subcellular Localization:
Nucleus.
Sequence:
MAVGPTEGKQPPSESFSPTHHQIIAPSPILAVPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNSSGMGCRSRRADGAASPTPSDSSDSDISLGTHSPVPSSLQLQHSPGSTSNGANDREESLSVDDDKPRDLSGSLPLPLSLPLPLASPTHTPPQLPPGYGGGAGAGPGGPLTGPGCLPPFKLDAATSLFSAGCYLQSFSNLKEMSQQFPIQPIVLRPHPQLPQSLALNGASGGPPLHHPAYAAAYSVECVPGGHGPPHPPPKLRINSPEKLNSTAVAAAASVGGGGGNQHHEPTTTGYHHSGQLMLHRPFSTSPELKHSAPEIT
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MAESLIGSAAMKKPGDGFAVPVSSSSNGSLFQRRIEFHPAKKPFSGFSTGNGDFHLETLNPSSDSQRTAATANGGTSVSKGKKSESVDFFEHELDPELSFGITFKRIGAGLENLGNTCFLNSVLQCLTYTEPFAAYLQSGKHQTSCRTAGFCAMCAIQNHVRRALQSTGRILAPKDLVMNLRCISRNFRNARQEDAHEYMVNLLESMHKCCLPSGVPSESPSAYEKSLVHKIFGGSLRSQVKCMQCSYCSNKFDPFLDLSLEINKADSLRKALTHFTAVEQLDGGEKQYQCQRCKQKVRALKQLTVHKAPYVLTIHLKRFGSHVPGQKIDKRVEFGPSLDLKPFVSGSYEGDLKYTLYGVLVHAGWSTHSGHYYCFVRTSSGMWHSLDDNRVVQVSERTVLEQKAYMLFYVRDRKSVAPKKPVAVLPKENTVGNAMQNKECGISVHGPKEKAQNGLVESRLSFSDCSRAVSQGQALCPTKEPLVKETSVLKSNGFITKAAKGPSLSKVAPSKPSLKEPHLKDLAQGQLGAEVSPQSTPSLANGSRNASNLNDVRIASIGAKHNPVNMCDGSKKDLNHNAGIVNEGSKFDLSIPVATQPDCTVLQNSGCEKLIKSNLPHENGYVGAPQEVISNRIIDEQSKENFTPRLSKESNVKIDQNGCGDYTIGISCPKVGEGDRRSTENGSVEISRQVSMDGMSGHVEASDLRHNQKKLKSMKKLLKCRVAGMHLSSSIMFRKSLSLRKKKYKKSKHRKLELKGFTRKDLEENGMSRGFGPSTSEQTRMVALDATHSRKQRARSVMKEGNINMAAKGAKGSKRYSFNNTVDEDFVQRISNNSAVLATNELSEKSLHSNSVANHYDAREPDKLHDKKRGSSQNGLIGMLMRGAETTVARWDGVELPDQILESSIAQSTSIGYVADEWDEEYDRGKRKKVKHQNNCFGGPNLFQEIATMKAQMKKSKMDQTSSGNRPFRI
The following text describes a protein:
Function:
Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.
Subcellular Localization:
Mitochondrion. Note=May be localized in mitochondrial RNA granules.
Sequence:
MPATLLRAVAGSHRVLSKAHQCRRIGHLMLKPLKEFENTTCSTLAIRQNLDLFLPDKTAGGLNKSQILEMNQKKSDTSMLSPLNAAHYQDEKAHLPTMKSFGTHRRVTHKPDLLDSKWFIKILKRHFSSVSTETLVPKQDFPQMKRPLKASRTRQPSGTNLPVVSVNEDLMHCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMEPTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MEAESTKASSKAKVKMKKVLMNEHHGDGLLGCDGGDNSGGSFDGNVKKKKCGHSGGGATSGTRCCQAEKCTADLTEAKQYHRRHRVCELHAKAQVVIVAGNEQRFCQQCSRFHELLEFDDTKRSCRRRLAGHNERRRKSSSEIKGTRKTLACMEADGREMFQGSCERE
The following text describes a protein:
Function:
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Sequence:
MLPTENRLRRREDFATAVRRGRRVGRSTLVVHLRSGATDPHAPGESAPRTRAGFVVSKAVGVAVVRNKVKRRLRHLMRDRIDLLPPGSLVVVRALPGAGDADHAQLARDLDAALARLLGGGAR
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MHNTNLKYFTSPLNSTTLASSAMLYHSTLRSSSPKSAICGRFSGKSQQVITLSSTGNALYLYSHDGDTGTVTLIHTHLTHCQVREIRAFRLPGLKKDYVIASSDSGVISVLEFRHNRFVSLHKEAYGRSGIRRVVPGEFLAVDPKGRACMLASVEKSKLVYVLNRQGADIVISSPLEAHTSCVTYFVVACDVAYENPVFAAIETPVGETSPGKQLVFYELDLGLNHVIRKAPVDIPNSTSHVTAVPGGTDGPGGVLVFSTNAIVHHVAGAAGGASTGAAGSTKIALPKPAAGYDNVIVASALHQSRDLFFYIAQNTRGDLFKISRDSETQHWSVLYFGTMSCVCTSLTILKSAHMVCLSEQGDSHMMFFESLGDDDAPENVYDVISPSPYLTVTQTLFELKPVFDSVVGVNTTSSDHVGPVPNVLSLISATRGGLKLISHALKPSIIVASPLPEPPSKLWTMRDGAGSDKYIVLSYANATLVLEIGDSVVETTSSGLTLDKPTLHCGSVGSSYVQVMTDGMNVIPMSREGSSESLPATKWTAPSGQVICASSSSHQVVLGLTSSLFYFEDTPGSELSAYDGAYELSSPPTAVAVAPVPAGRVRSPFVAVATDDETVRIVSVDPESMFETVAVQGLMATASSLALLSVGQVLYLHMGLANGVYVRVELDPLTGEIVGSWSKFVGLGRLSVVPVTCGGEESILVSSRGVKTCLGHVNATSDTWVPTGGNSAPFFALDAISGEPLDLAHSFHTQDCPHGVIGVAGSTLKIFTVNTAQKWTENEVKLEGTAKRLIQHDATTLTITQNPDRLVSVDNGAVGITKDLGGPPTSICEVMFGDGKRYFAVGGSRDGSPGTSGTSGYISIFSSSSLGHVHTTEVEAPPLALCAYNGLLVAGIGSQVRLYALGLKQVLRKAQIELSKRVTCLAHFAGSNRVAVGDIRQSVTVCVVLEEDSGHVIYPLVCDKISRQVTCLFFVDYETVALGDRFGGFTMLRIPSEASKLADEDHNAVHLRQLEPTLNGPAHFRFDHVASFHIEDVPVAIHMYNDYLVVCGLLGTVSAFVPVVSPKQSRDLKTIEKFVCASDPGLMGRDHGRFRGYYVPVKEVVDGDMLREVLVMDEKRREEVGEKTGLGVEGAVGRVVNVMKCV
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSYNRRKSNKGKSVIIFTLLVVVIAVLAYAGSYGLKVGNYRFKSFGETINKGLDLQGGVSMLEEIQADKVDEKTVDRTIELISMRVNKMGVSETTVTREGQKRIRIEIPGKYNAKEVIDSVGKTGELKFVGPDKSTILTGKDVKDATAYINQEDNSPTVGLDLNESGTKKFADATKKFIGQPIAIYMDEEELTKPVVQAHITNGKAVITGSKSIEEAKRQANIIKSGALPVAVKPVEVRTVGATLGANALDLSVKAGVVGVGLVFLFMLIYYRVPGLLADIALVLYIVLVLATFSTIKATLTLSGIAGFLLTIGMAVDANVLIFERIREELKTGKSIKSALESGYHRALSSILDSNITTIIAGIVLYNLGSGAVKGFALTLMIGIILSMFTAIVVTRLLLKLGYDIGILNSLACFRVKRGEE
The following text describes a protein:
Function:
Exhibits ATPase activity in vitro.
Subcellular Localization:
Mitochondrion.
Sequence:
MYIRGLSRVSAHLSRYNAGHSSIRSKVCYEKISKRYISLTQKSFKNEEKLVIGGVSRKLTESKYVELIPSKYDNIDPDQSTLKKLRWMLQKDALGQDMFLIGPPGPEKFKIAHLYAQLVNQEVEYIALSRDTTESDLKQRREIHNGSAHFEDQAAVRAAIHGRILILDGIEKTERNVLPVLNNLLENREMPLEDGRLLISSSRYDKLLEASRSTDLEKWKLVRVDDKFRVIALGLPVPKYRGHPLDPPLRSRFQALKIDQKPFKDQLLTLTQIAPGVPENSLIELASFAYAINASESKAQGLPDFPIDSLPLAAALMENNPNLSVGSVLQRLYPYKTFLTKDGQKMVEDLMETFKIDNNLQTENIPIPSMSRGTATGDYIPTDYHQQIVKELKESIQIHDICLIGNRGCGKSTLIRQLANVLSLEIEPIMLYQDMTSRDLLQQRSTLPNGDTVWTPSALLKAAIDGKIAVLDGLHRINTGTLFTIQSLVHEREAQLFDGSRILRHDRYDALQKHLNCSDEAMAEKKLLKVHKDFRIVALAEPPNSTGKTSSHWLSPEVLSMFFYHTLRPMNKAEEINILEALIGDKLAISMHPIMKLAQHLRNSSDPTLSGLASSLSTRQLLRLAKRLKEYPSSDPWELVERTCLSKFLPRMPQEALFKAMKSCGMEKATQLESGDSQLTCSVEGGILKLGQTKTKIYEQGNMAKVPDVVFYDTDQHLRVLEALLQDFLLGDHLLLVGNQGVGKNRLIDRLLALMNRPREYIQLHRDTTVQSLTVQPTVFQGIVKFQDSPLVRAAQDGSVLVVDEADKAPTQVTCILKTLIENGEMLLADGRRILPRGVRCDTKESDIVRLHPDFRMIVLANRPGFPFLGNDFFASLGDVFSVHAVENPSFESELELLRHFGPSVEKRTLTSIVQAFAQLRSLADQGMLTYPYSTREVINVVKHLERYPKDGVVRTVSNVFDFDAYSSEVKELITRVFHEHGIPLGASVNNIALAVEQPLAAPICGGDGDLSGPKVGKIDPKNTPHVGGNTWAGGTGGRDTAGLGGRGGPYRLDAGHDVHQVSDEDKAAVPEEIQRAAREMGKKAYQERLKQIRMDPVDAELYQKFSSSVQKQVTALKVILDNIQAKGKERQWIRHQTYGDLDDSKIIEGLTGEKNIYRRRAELHPELGAPAEKPKHLRLLVDVSGSMYRFNSYDHRLEREMAAVLLFMEALEGHSEKWRYDIVGHSGETLNLELVNVGRPPKDDKQRFEVLLNMHAHSQFCMAGDHTLEASKQSIASLSESTDLDEAFVILLSDANLDRYGIPAVHLAQSLAATDNVRSAVVFIGSLGDQANRISQQLPAGSAYVCMDLEKLPQILQQIFTSVLLST
The following text describes a protein:
Function:
Lipolytic acyl hydrolase (LAH); Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Hydrolyzes phospholipids as well as galactolipids. May play a role in disease resistance.
Domain:
The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
Sequence:
MKTILSIDGGGVRGIIPGIILQKLEEQLQDIAQINNKLNPILEKETWNDYDEVNIEKLEDRLHDILSRDKKARLVDYFDVVAGTSTGGLIAIMLVAGRKSAANIATADSQPIFQAKDIKEFYMKHCPEIFPRYRFGILQTLKMIFFGPKYDGKYLRELLQNRFGDTMIKDTKPNLVLTTFDINLMQPTIFTTYDAKLSDNKNALLSDICLGTSAAPTYLPPWSFFSADKSRMYHLIDGGVAENNPTLVALNSLSKEEDGKSKEVDMDDVLILSLGTGSATRSNVPYDTDSVSGWGCLEWMYQSKGNRHPILDCFAESSADMVDIYASTIFRFDSRNKNYLRVQYDDLKVEESSMDNSTPENLKRLVQIGRKVVGSPMVAFDLSNSQRQAVSLARDISHAKGWKILDSFARKLYNARISVVVVRC
The following text describes a protein:
Function:
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MWKLLANVVSNVVSQGWEVFVEVFVVSYRHIPSHTLSVPTDITVDKLNMLANKTLNNISDKEFESVAFDFLISSTILRTTLEEFVQENHVPVESVISIECIVQEPAPEPDSDIALLDWIGAIRCNDKFIASATYGGELVLWNHYGKKLTSSVLHEEAIKCLALLPDQKEDRIVTGGHDQVLMLSDVETHGSSTFIKPTCVLRGHERSVEAIAVNTDGTRTVSGGFDKMLKVWNTDKDDTSTVFEKTRSEKTGKKKRTDIITKIPMVTLSGHKDAIVSAVWSPNSAKEVLTVSWDHTISIWDLELAGQINTLAAKKAFTSISVCCSSGMLITGSVDPVVRLWDPRSHEGTLVKQSFIGHCGWISSVFWNKVKENLFISASFDKTVKMWDVRSNKTPLYDLVGHSDRILCCDWSVNELIVSGGVDCTMKTYRRKM
The following text describes a protein:
Function:
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Sequence:
MAKAVKKEIAKSEEVVSIKAPRKEPGKKIPVVSIVGRQNVGKSTLFNSLLKKKLAITEDYPGVTRDVLSARIYQEEKDLDFYLCDTPGLDIENPDSLSQTILETAYRQLRESDVIVFLLDKNLITTADHGLLNYLRREDKVANKPIIYCVNKADKELDEFDLEEFYRMGLSEVLPISAIGRKNLGLLLEKIQFFLKDKPGKVWIEKISASKKKEAQPLPLAEEDYEFRLAIVGKPNSGKSSLLNAICGYERAVVSDVAGTTRDSIDTLLEFGDRRLLLTDTAGIRKQSKTAEALEFYSYQRTIKAIESSDLVIHLLDAKKGFGDFDKKITSLLQEKGKPFLLAVNKWDSIEDKTDKTFKEYKEKLYSRFPLLNEVPIITISATERLRVQKLMDLSFDLASRSHRKVSTSELNKNLKNWMGLAGRSFSAHQPPKMLYCTQVSTSPFHLILFVNHVEYFKSNLVSFLKKKLTETYDLQGIPIRLEFRSDRK