lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (CaaX). Seems to exclusively prenylate CaaX substrates with leucine in the terminal position. The beta subunit is responsible for peptide-binding. May negatively regulate abscisic acid (ABA) signaling in guard cells and auxin-induced lateral root initiation; Negatively regulates ABA signaling in guard cells. in negative regulation of auxin-induced lateral root initiation.
Sequence:
MSETAVSIDSDRSKSEEEDEEEYSPPVQSSPSANFEKDRHLMYLEMMYELLPYHYQSQEINRLTLAHFIISGLHFLGARDRVDKDVVAKWVLSFQAFPTNRVSLKDGEFYGFFGSRSSQFPIDENGDLKHNGSHLASTYCALAILKVIGHDLSTIDSKSLLISMINLQQDDGSFMPIHIGGETDLRFVYCAAAICYMLDSWSGMDKESAKNYILNCQSYDGGFGLIPGSESHGGATYCAIASLRLMGYIGVDLLSNDSSSSIIDPSLLLNWCLQRQANDGGFQGRTNKPSDTCYAFWIGAVLKLIGGDALIDKMALRKFLMSCQSKYGGFSKFPGQLPDLYHSYYGYTAFSLLEEQGLSPLCPELGLPLLAAPGI
The following text describes a protein:
Function:
Involved in RNA-directed DNA methylation (RdDM).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAQQEASPSPGAEVVGRAFVEQYYHILHQSPGLVHRFYQDSSFLTRPDVTGAVTTVTTMQAINDKILSLKYEDYTAEIETADAQESHERGVIVLVTGRLTGNDNVRKKFSQSFFLAPQDKGYFVLNDVFRFLEEKEVTAQARSVPINGTTRDVQAPIEPERVVVSHEPEVEPEPVASIEEEDLDNVAEVYDPSDKDEGVVVDVEPIEPPTQISHNEILSVPQGDAPKHSYASILKQMKSSPAPTTHVARNKPRPAPVNQKLTAPPAEPAARPEASAHENVPNSSHVDVEDDGHSIYVRNLPFDSTPTQLEEVFKNFGAIKHEGIQVRSNKQQGFCFGFVEFETSSGKQSALEASPVTIGDRQAVVEEKKTNSRGGGNNGGSRGRYFSGRGSFRNESFKGGRGGGGRGGYGRGGGEFSGRPKSSNPRNGGEGYQRVPQNGGGGRGGRGEGGRGGARGGGSS
The following text describes a protein:
Function:
Bifunctional nuclease with both RNase and DNase activities. Involved in basal defense response. Participates in abscisic acid-derived callose deposition following infection by a necrotrophic pathogen.
Sequence:
MTSIIQTAAHIGLHLHCSASLQQNSSMAVLSSRGPVTNSSKLNQSSSIVLANVGLGTSSERRSWQMRNSSMSFNNGLSIDEPFSENEDDCVDSTVLEALEVKSRPEGFVIKMRDGRFLKCERNVPDSGCLPDYGPQPAIVLQLNKCSKLLLPIIVLELPCMMLIEALRNVPVIRPTVYDVMKDMIEVMGYQAKMVRIMRRVHEAYCSRLYLTKVGSDSGDVLTMDLRPSDAVNLAVRCKVPIQVNKWLAEGDGVFVVDETAKLQSRTPLSLAASLTMTNLDRPDSTSCVAAEEFALVRGMMVAALEERYSDAAKLRDELRHLRSRKKLSRQFKQI
The following text describes a protein:
Function:
Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations. Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor Gid4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MTSTPKNLEKQPINFDNLPLYLQGTNYGENVLRSDPRWLKWEKYLREFDMTREGNVTNTPKAIPSSWNPNDKSDSLELMNNNMGVYFFGPEAGTEHDAASVKADHAIPSNTSIYYYEIQILSRGKEGKMGVGFCRKSMQTNRLPGCTAESWGYHGNSGEKFNCSKTGEAYGPEFTTGDIIGCGVNFINRTIFYTKNGAYLGVAFKKVSDVLYPVIGLKSHGEHVEVNFGQNPFLYDIDYAIQMEKNKLFEQATKSPKQEELKQRQEFLNELISSFLLNNGFVETAKKFCPENTEVSDASIRKEISSMLANGQLDLAMTKIDCQYPVAIQECPDLIMSLRFLRFLQLVKVTHDQRLTKSKGTKQISQEEDLRILQPLMNYAQELSNDYEHTKSSNLQAMIKLSMGLLAYFDPFSSPLSFFMSSDFHKYMAEQINCLLLELTGHSPDSELRRFLQHTVCLNDLLCRNGCRSNTLFNVQSDFLSPY
The following text describes a protein:
Function:
Positive regulator of protein phosphatase SIT4. Involved in directing expression of TOR-repressed genes and in dephosphorylation of NPR1 in response to nutrient starvation. Negatively modulates K(+) efflux of the cell by the Na(+)-K(+)/H(+) antiporter NHA1.
Miscellaneous:
MISCELLANEOUS: Present with 5960 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFWPFGQNLNHSNINKILDEYFHVLHELERINPSVGKAIPAIFNNVQERGTSDSLDSIPEEYSHGDEVKTARGDQKSRFEKDDQQERYEKEEEERSMNSSESSTTSFSSGSTSKTDLDEEDISNATAPMMVTTKNLDNSFIERMLVETELLNELSRQNKTLLDFICFGFFFDKKTNKKVNNMEYLVDQLMECISKIKTATTVDLNNLIDYQEQQQLDDSSQEDVYVESDTEQEEEKEDDNNSNNKKRRKRGSSSFGNDDINNNDDDDDANEDDESAYLTKATIISEIFSLDIWLISESLVKNQSYLNKIWSIINQPNFNSENSPLVPIFLKINQNLLLTRQDQYLNFIRTERSFVDDMLKHVDISLLMDFFLKIISTDKIESPTGIIELVYDQNLISKCLSFLNNKESPADIQACVGDFLKALIAISANAPLDDISIGPNSLTRQLASPESIAKLVDIMINQRGAALNTTVSIVIELIRKNNSDYDQVNLLTTTIKTHPPSNRDPIYLGYLLRKFSNHLSDFFQIILDIENDANIPLHENQLHEKFKPLGFERFKVVELIAELLHCSNMGLMNSKRAERIARRRDKVRSQLSHHLQDALNDLSIEEKEQLKTKHSPTRDTDHDLKNNNGKIDNDNNDNDDESDYGDEIDESFEIPYINMKQNIKLRTDPTVGDLFKIKLYDTRIVSKIMELFLTHPWNNFWHNVIFDIIQQIFNGRMDFSYNSFLVLSLFNLKSSYQFMTDIVISDEKGTDVSRFSPVIRDPNFDFKITTDFILRGYQDSYKFYELRKMNLGYMGHIVLIAEEVVKFSKLYKVELISPDIQVILQTEEWQYYSEEVLNETRMMYSKILGGGSYIDDGNGNIIPQLPDNTTVLTPNGDASNNNEILDSDTGSSNGTSGGGQLINVESLEEQLSLSTESDLHNKLREMLINRAQEDVDNKNTENGVFILGPPEDKNSNSNINNTNHNSNNSNNNDNNDNNDNDNDNTRNYNEDADNDNDYDHE
The following text describes a protein:
Function:
Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development, especially heart development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
Subcellular Localization:
Secreted.
Sequence:
MGLQALSPRMLLWLVVSGIVFSRVLWVCAGLDYDYTFDGNEEDKTEPIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQSPFGKLGHITGGFGDHGMPKKRGALYQLIERIRRIGSGLEQNNTMKGKAPPKLSEQSEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFTERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESSGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIMVSEGYHVGLTFQAFEIERHDSCAYDHLEVRDGASENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVIAPSQYRISVKFEFFELEGNEVCKYDYVEIWSGPSSESKLHGKFCGADIPEVMTSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYTCQCRNGFVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWVISAIPGHRITLAFNEFEVEQHQECAYDHLEIFDGETEKSPILGRLCGSKIPDPLMATGNEMFIRFISDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQLDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEVFDGLSSKAVGLGRFCGSGPPEEIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPETMHAKN
The following text describes a protein:
Function:
Required for promoter sequence element PCB-driven, M-phase-specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15.
Subcellular Localization:
Nucleus.
Sequence:
MNFNSTNPYYFTHEKNLNNASKYSELPIAYQEIPLQSLPPYPKVASKLKGVVAGGKENNIASFQKPSSKATRPYIPSYTRLTYSVPPLPIPPPSEQSLDTIIYRNPSVSSSQSQEPEEFFLPLDDGKKPPYSYAMLIGMSIIRSPDRRLTLSAIYDWISNTFSFYNKSNNGWQNSIRHNLSLNKAFMKIERPRNLPGKGHFWSIRPGHEEQFLKLKLRKPGVNSRPAPPVQDVTSSTKYGSSTGSSGFNTFNTSPHIFNQRHQYLQNYYTASLTNIPTISNVNATNFHPLHSQQPYVDTPGIDAPSDLEAKFSDLGVSSVVSVTSPLQSCTNSPSPPLSSPASSASPSESLRNESLGIKSAKSLGLNKDDAPVEGPPVSHLEKDVETPSVHDSVLGFNDTVTNLGKKGLKDGTTNTLQIPAVRLPSLPSSPTIKNPSGLLLKRSNSIDFPTPPKALCPKLFCFRDDIVADDYTKFSLLSPIRSDMSGISASPNTNLKEHRTRILQMLATPDAKQLSSLTSSDAEFWSVTPLKSSILRNGDASKQVTLSESPKGDSLLDGGSLSYFTNNISSVAGLETPSKLPMSKSFDTFEDDFLDPMDMLSFENHFSDFNSNRKVSPVKREVRRKYISSATTIHSSAAQDDTYLPSPTKRKMPLLRQTSTLF
The following text describes a protein:
Function:
Lignin degradation and detoxification of lignin-derived products.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MATTTRGPVTMRLCFFSAAALFLLCFLVPAAVAEERFYEFVVQETLVKRLCNTQKIITVNGQFPGPTIEVYDGDTVAIRAVNMARYNVTLHWHGLRQLRNGWADGPEFVTQCPIRPGGSYTYRFAIQGQEGTLWWHAHSSWLRATVHGALLIRPRPGVPYPFPKPHSEFPIILAEWWRRDPIAVLRQSMITGAPPNVSDAILINGQPGDFLECSAQETSIIPVAAGETTLLRIINAAMNTELFVSLAGHKMTVVAADAMYTKPFETTVVLLGPGQTTDVLVTAHAAPGRYYLAARAYASAQGVPFDNTTATAIFQYKGGAGCPTTAGGAGAAGAVAGAGVGAGAAVLRRQPWASRAGANAAVPAGVQRHEHGHGVLEQHPEPGAGEGARAGDPGGVHHGGVRPLQLHARPVLPGTQQHPVRREHEQRVVPAPQHRLPPAGALPPHPRRVHRRLPADATRVLRLHLPERPPRAVAAGEGHQAVPRQVRRGGADRLPGHRHLRRRGASHAHPRLPLLRARHGVRQLRPGEGRPQVQPRRPAQPEHHRRARRRVGRRAVRGGQPRGVAGALPHRRASHRRAGHGAAGGGRRGGAGGHHGAAAGPAVVRPVEKNFSFLWVCVVVYVRTWWRFEEGCVHCTCRWYTLCVCV
The following text describes a protein:
Function:
Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
Sequence:
MKNSQNHLAQIVALLNDRRFHPGTAIGQALNISRTAVWKTVQKLKKYEIPITADKSKGYRLERPFLLLDPQKIKNAVQAEPVRIDLFEQINSTNEYLKRVNHPQQLNICLAEMQTQGKGRFQRAWHSPFGQNIYLSLKYPFHKDVSELAGLSLVCGLAVCNAIEENCPLTKPIFVKWPNDIICEDKKLAGILIEIEAETHGFCSAIIGIGLNVNMEKEQDKINQPWISIKNLTATDQDRNQLCAALINQLVNCIDCFEKKGFNEFLASWKTKDYLLNKQIQLKSGRQELQGKSLGINPQGYLTVQLSDGSERIFSSGDTTLLK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation.
Sequence:
MIPLHKDNQEEGVCPICQESLKEAVSTNCGHLFCRVCLTQHVEKASASGVFCCPLCRKPCSEEVLGTGYICPNHQKRVCRFCEESRLLLCVECLVSPEHVSHHELTIENALSHYKERLNRRSRKLRKDIVELQRLKAQEGKKLQALQFQVDHGNHRLEAGLESQHQTREQLDALPQQWLGQLEHMPAEVARILDISRAVTQLSSLVIDLERTAKELDTNTLKNAGDLLNRSAPQKLEIIYPQLEKRVNELLLQPSSEALTCSSLGHLTSGSPQPPLSPFSNLSRPPLDLPSTSSGLPAPEHVPISSCPLSSPDA
The following text describes a protein:
Function:
Leucine-rich repeat receptor protein kinase that acts as sensor of extracellular hydrogen peroxide. Required for intracellular calcium influx in response to extracellular hydrogen peroxide. Mediates hydrogen peroxide-induced activation of calcium channels in guard cells and is required for stomatal closure.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSSRTGASLLLILFFFQICSVSALTNGLDASALNALKSEWTTPPDGWEGSDPCGTNWVGITCQNDRVVSISLGNLDLEGKLPADISFLSELRILDLSYNPKLSGPLPPNIGNLGKLRNLILVGCSFSGQIPESIGTLKELIYLSLNLNKFSGTIPPSIGLLSKLYWFDIADNQIEGELPVSNGTSAPGLDMLLQTKHFHFGKNKLSGNIPKELFSSNMSLIHVLFDGNQFTGEIPETLSLVKTLTVLRLDRNKLIGDIPSYLNNLTNLNELYLANNRFTGTLPNLTSLTSLYTLDVSNNTLDFSPIPSWISSLPSLSTLRMEGIQLNGPIPISFFSPPQLQTVILKRNSIVESLDFGTDVSSQLEFVDLQYNEITDYKPSANKVLQVILANNPVCLEAGNGPSYCSAIQHNTSFSTLPTNCSPCEPGMEASPTCRCAYPFMGTLYFRSPSFSGLFNSTNFSILQKAIADFFKKFNYPVDSVGVRNIRENPTDHQLLIDLLVFPLGRESFNQTGMSLVGFAFSNQTYKPPPIFGPYIFKADLYKQFSDVEVSSKSSNKSILIGAVVGVVVLLLLLTIAGIYALRQKKRAERATGQNNPFAKWDTSKSSIDAPQLMGAKAFTFEELKKCTDNFSEANDVGGGGYGKVYRGILPNGQLIAIKRAQQGSLQGGLEFKTEIELLSRVHHKNVVRLLGFCFDRNEQMLVYEYISNGSLKDSLSGKSGIRLDWTRRLKIALGSGKGLAYLHELADPPIIHRDIKSNNILLDENLTAKVADFGLSKLVGDPEKTHVTTQVKGTMGYLDPEYYMTNQLTEKSDVYGFGVVLLELLTGRSPIERGKYVVREVKTKMNKSRSLYDLQELLDTTIIASSGNLKGFEKYVDLALRCVEEEGVNRPSMGEVVKEIENIMQLAGLNPNSDSATSSRTYEDAIKGSGDPYGSESFQYSGNFPASKLEPQ
The following text describes a protein:
Function:
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Sequence:
MRLSNADLERLKSMANALRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYSLLHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASQYAQNLLDKEAISHKVYCLCGDGDLQEGISYESASLAGHLRLDNLIVIYDSNQISIEGAINISFSEQVKTRFVAQNWEVLECDGHDYQAIHNALEEAKKSTKPTLLIAHTIIGKGAVGLEGSEKTHGSPLNKEVLKQSKENAQINPNESFIISPKNKMHFEEVKVRGVSLEALWEKSLSPKIKEKIHALKDFDFSAIHYPTFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTQLKHSGDFPLGQNLHFGIREHAMGAITNALAAYGLFVPFCATFFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLNHLRALPNFYAFRPSDAFENTACMQIALSLNAPSGLILSRQNLPVLDEVSKERVLKGAYVKHHSKDPIITLVASGSEVSLALESAKILERENIQTQVISAPCFDLLIEQDESYLKELFKGKVLVIEASRAIEWYRFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLNA
The following text describes a protein:
Function:
Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
Subcellular Localization:
Secreted.
Sequence:
MKFLVFAFILALMVSMIGADSSEEKFLRRIGRFGYGYGPYQPVPEQPLYPQPYQPQYQQYTF
The following text describes a protein:
Function:
Negative regulator of transcription elongation.
Sequence:
MSAPASASEATDLAPSLQDESSSGVGSAADGIDDTSAAVEPRRGSRTRKPTSRAAGLEPTEIASASHGAQQKVTRSLRKRKADDVGAEQEETTEHEVATVFEKESTEGVQEDADEKRYCICHGRDDGTFMISCERCQNWFHTKCIGITQKAAKKLDEYICEACSSTAAASDKAAAPKQIKRYKSSRAQQASRIAKACTEESDSEHEDKEVDDFEEESASDDDYIGEVEDDASNHEVAASPNVTQPTPSARPQQRKQVSSSIAILKANTAASDSANAGRVSQRRTSDASRRASASSKPAAASKKGASRKPTGPTDASTEEARSRARKVLATALEMIFSSATEKKKSTGAADEDEESDEQRAHSFASLLEEDLFDSNADTHGSIRVVGSKYKDRFRTFLFSLKDAKNTTLHSRISSGQLQPSELGKMTNEELANDSIRQATEKARLEALQRSTLRSEDAGPLRKMTHKGEIEIESDAVIARDQTDKFERALDAKQKGRSQRPPASRVSESEPVIPTSMHAAEDEDEQGTADSLAKDDPERRSAPAPKLAQASPSRLNFGDVWIKSEGDASSDNHSKEPQESFGFGIGSPHEEEYDQSIGVDQDGAATAGVDDFIDSFLDGAADEIDSAARIVSEQEVQRSTTPGVDPPGSTLHRYRSVIWNGLIDLPDVFAFQGHVKQIAGRSLTSAATVWPRFFPERALLIAGRLPSKAAVDYLLQVVNAPRTEILAFTMEPGVVKDSAVKQQESDLFSFDGMFQHFKNADRWGALHISSSVKGSLIKDFYLVPLQKDEEVPLWLDMVESDCLGSDWHAKRDRDLLVLVAVVIRDAMQNELSKAERSPTRPRSATNENRRNGHGQTASVPEEPYNPSAGLHLGLDQSGMDHTGAVSGAAPSVGAFGSDALQSLLRTLGKTTAPPAPGSVQAALPTGLSSSVPILPAVSPSGPPPGPPPGPPPVLSGVSPPAVRSPMAGSWSPYPTAGALGDAATPTQHWQQQQPYLGYHQGYVPVADPPAYGQGGGWGQQQSWHPPPQTSAPPAPQEMPEEEYPGQYNPDFLAQAGAGTQRGGEGRGFGYGHGQGQGRGRGRGGWSRGRGW
The following text describes a protein:
Function:
Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.
Subcellular Localization:
Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes at kinetochores in meiosis I but undetectable in meiosis II.
Sequence:
MDKIWHMGPRGDYTRKKRAGERLNLTPKPDLALPGRTEALPGLKGKGKEQGLRKITEKKELSRLTGSSSQRPSLLSVTGGEHLQENSPGQETPEEKTPPCETVTDTFEMDSLLSSTELVSGPAEQDDFSSCLPSCSNAELHTESTDERGSSFPSPELFRGSDCLDWEHPKLEDYMFYKNSTLLDTSKAVVIEKAPQFANLSAVLSSSSKNYEKRHRKIGMTLAAQHLSPEPKYASNLASVVDNAASEVVFAEKTGPPTTEKTQKKPENESEDSGPLVQTKLSSGHPDNKALCSPLSSALESTAVRYTLLPQPLEPVLKKGCILPDKQSKALLTSTPSSDIAEFVIDLSPVQNVSFEELFPNVSNYVNSSEVVPVSSLQESSSNEFSPNTSEICCIIRSSPGTRQMRRKDPAVKNRCSPPKDVPLDIIMKTNGRT
The following text describes a protein:
Function:
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIIQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKMELDALRSKYEALQNFARTVARSPVTPVRGPLTSSMGPLVPGKVATTSVITIVKSKTDARS
The following text describes a protein:
Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Sequence:
MEKMNEFSNNNNNNNNDDDDRGSLKLKQLRNSIKGKKRKHDSITKDNDIINASKVIIKKNVMTTQLFDDINKLSYVYFLLKYYFDNNPLKILNENFYLKDDVLYITEILIGHILWVFDEKQNKLYGSRIIELESYNGVNDKASHAYNNRKTNRNMSMFEKGGISYVYLCYGIHNCLNIVTNIQNIPDAILVRSTEPLYNIEYFLSNKFEKISQYLLSNSIFIHKNIKEQQKNNSTPKNKRNQQGNISNKDGNIINETNYLTKIDELINIFKMIKKKQLLKLCSGPGCVTKSQDITRQDDKQYFFVGTNIEKENKTNTINNNNNNKRNNCSNLQKNSKYFNNNDYIKKNNNKSNNIHSDNDCSIDISNCTKENKQTNHCKNEYIQDHVNYNELMEYYYFLGNIHEIHKSRFFITLCPSINDIMLFFENLNNPTYQNKHNYIYNIFNEHKNVLLQYFHFMKWDKENFIVQKDKRIGISYAQEAALYDYRFLLKNHPSVSIFPK
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MWPFQLFIDICWAAQRSPAMHYKQRDMSCGNVRRSRLLSCRTLLLVIGLLVTIARDTVADQQGTKVDMLPVELEASMQSSVLSELQAAASSVGEGPPTAIPDYSAKTEGAHTNIPDSSAIVGQVFQLKLPPGKTHASCNVHLTELGKKSLPSWLCWDKESCSLKGLALDRDKGSYRILVSEEGLAENTSSQVYPSTVFSIEVYPEDRADTEPALFTLQSDSSLQPFTCMSEEPVTVLTVILDADLTKMVAKQRVNLLSVMKKFSHVPLEHMRVVPVVNNRLFDMTAFMAGPGNAKKVIENGALLSWKVGCSLDHDSIPDISSVQYSAKDGTMSAKLGYPVVGWHIVNKKTHVVKRVRRHLNNTPTPVPSLLPPTVSQEPLSRPVPTPISPFIAPATDISAPPVRGPLPLPVKPTMRVRDQIAHTPVFGPPQPTRVLGTTSTLPIQPATTRPTIAEPTAMPTAPSTTKKPKPSSTKKPKKSKSSTPAPRQPKSTTVKTPKIRIESNTTPVIRNSIDHVIAWVGTYFELKIAADTYYDIEDGTTDKLRLTLLKSSKEPVSETSWIQFNSTIQLLYGLPEDEGNHEYFMMATDKGGQSIMDAFVVQVNRWSNNDKPSVMFAARFEGDHKSLNGDVNKKILLIKKLAYAFGDRNSSTVTLRNIRSGSIVVQWTNNSLQQNPCPKDQITVLSNRISDSQGKPKPAFIKAMEPEFITINISVFGTNECQRYTFIPPGEIPVPILPTPSPSPGTDRRSSDDVYLHTVIPAVVVAALLLIAGIIAMVCYRKKRKGKMTTEEQATFIKKGVPIIFADELDDSKSPPSSSIPLILQEEKPPLPPPEYPNMPGPHSSLLNQDLMEDFLIYQDDDPNAPPYQPPPPFTVPIEGKGSRPKNMTAYRSPPPYVPP
The following text describes a protein:
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MTLPSPLSATYWSTWSPVRPSATVIESVQRDQGEEWIGSWDAVGLYEANDKQPGYQTISLHITTHRLILIPSDSHSPHVPSLQTHLSYVRNTEYYSGFMRSSPKLTLTLGNPQSRDNDPAVESAGTWTCRVCGYVNERKGLGKSGKCGLCGVPYAQAVASPSVSATPSRAGTPNSSGFTPPSSTADDKEGESKVACPACTFLNSALLRNCEICATPLPRLPQLNTIREKPEKQQVVRLSFRKGGDKEAYKKLSSVLGDKAWEREGRSSAQTTSSNGERSGAGIDGILQSIDLSAKAQDTHMQTAFADLEALMLRAGEMVRLAQSLNQKLSSQQQAGASSPTGSPQGQTTEEEATMIRTSLVQLGLATPALTKEMVKNERAYHEGLAKELGGLLTGRDGESGLMVGEGGRGVVALDEVWGLWMRARGVALLSPQALIDTLPYLPNYTSPSIHSLRLPSSLMVLHTPTFSTLSILSRTLSRLEPSFPNSDPFEKSFSLLEFASTESLPIGLAQEFVGLMESQAGLVRDDQAGQGDGGVRWYRDIISP
The following text describes a protein:
Function:
As part of the exocyst, may play a role in regulated exocytosis of insulin granules.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle.
Sequence:
EVDGNKEKKDGQKNGEWPEAAKAEQLARGAALKWASGVFCRAGKLEGLAQYWVRETQRNSSIQSRIKSTLQSYLDGVSMGLEQLRSAITDLQRVQKELGSIQQDLASNAISFQNLQRIQEVMVEHAQLGSVVQRLPKLFSVPQLFSESLDLLRSDHLLEAHARLMELESLQSDILFQLRNRNLLSPEHLASVQSYFGGLLELNDALAQHLWHIVGHGTKLVSEDPALFVSALRIIEREEGIDAALLQRARPPDFLPPGRPKCWRQKFFQVIQDSIVAAHFKAVPGSIQDHHLTREYLASLQSSIRTELHIVKDLMVQCCPPHYNIFMTFATMYHQSLANHLHHLLTWDLDKQEIFALLHWTLHVYPSSEMMAHPDLLPEVDTSALGPLLPLDKIEYLEDTYLEKVQASISEWMQKTLALEFKEWFSKEEPESDYQGCFQTSLPNIIMKMLDENIQIASLISDTLREKMCNMTLGELETFLGSLYEDLVEFATEHQQEPKASKCYTQYLLSALNNCLALSASLSALYSGSSLEPPKVPPSLDLALEKVQKKACRLLLKEMLEELKPLFKQLPSHQWLSDESQLMSSICAVIEKHAKYFCRTREPTSTHLLSETEHLIRSQYLRALLQKRMVCQRMEERRQMASRMLQDASQFKELFCNLGLEEDKQTFKVIADLQELISLKDHSILILEVLGFVTKYPDVSDDHISMLLDLRGDISKEIHKNVLEVMAQNPQVLPENYEPIFSNILVPAPEPPFCLGKSKCA
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Subcellular Localization:
Mitochondrion. Cytoplasm.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MIVYSFSFLIFLYFCLYLNIKESIILGNCKIILSRPFKEEKKKKDIYFFFNSGKNLLKRKKSTFDLLPLHSNKRRRINLFINNDKKKKIKSNSNNNNSNNNSNNNNSNNNNSNNNNNNSSSIKRECGEPFFSFYSYENILTVHNNKILKDQNNNYVLLHLCKKIKKKYKKEKNKKREYCNHYKFMYLNSIKRKDIFIKLNKINNKSHFYKDIHKSNKCIKTFIYSSSHNFHNSNYSSLNAFSFKSLFTKNTYNRSFLNFLKYTTKNNLKEKKNIKDFFSFSIKLGKDKNINLDNLKKGYYKDINTNNRSNHNKHNNNKYNYNNNNCSSNHFCSNHFCSNHFCSNHFCINMDMNDKLNNRNNWSNTNNPKDDNIKNTNCSTNDEGQKKYMSAEEVRNNFINYFHKKNHTIIESSSVVPYNDNTLLFTNAGMNQFKKIFLGNADKNSDLGKLKRAVDTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKEESISFAWDLLTNVYKINPDRLYVTYFGGDENLSTCPADHETKKIWMKYISEDRILPFGLKENFWEMAETGPCGPCSEIHYDRIGNRDASSLVNKDDPSVLEIWNIVFMQYNKDENKNMNKLPFPCIDTGMGLERITSILQNVDSNYDTDLFQPIFKQIKELFPYLPNYEGKINEQDVDKIDTAYRVISDHIRCVTVAISDGCLPSNEGRNYVIRRIIRRAIRFGKQVFNIKSNVLWFYKLVDSVCFILGNTFKDLQNPDKINFIKNTIKQEEMVFNKTLEKGVEQFHKIIKKNTKNNIFSGKDAFDLYTSFGFPIDLIQIMCEEKSFNLDLQEFNDLFKKHQLVSDTNNFKINKFFDIPVEKSHELKNVHNINPTVDHFKYEWNNNCANDGDNKDIKFETYVQVIYDGNNFLDNFTLPSNNDEQVLEKEKSIEENKKKYALILKETNFYYENGGQIYDTGIIQNDNMKFQVLNVQKINEYVLHIGVFLKGYVSKNDKVQTIVDFDRRKLVACNHTATHMLNFMLRKVLTEKYTNSGKSSKTHEGNNEKHEMSENDINSNNNYDNNKEEKGFSIFTCEQKGSLVDDEKLRFDFSFIENINIDAITKIENEINKLIKEELNVTVKTMDLDESKKIKGIRAIFEEDYADKVNVVFINKDVNNILNNMNIDYTYLHSIELCGGTHIGNTKLIRKFLVTSEESIGKGIYRITAVTNKKADEIEKTFNDLYDKYKHVLQEPNENKLADVQNYKRTLKENKFLPYIKKYHILQELEQIEKTIVEKTKNMQKELFNKATNIGKDYAVQDKNNILLDIKFFDEIKGNQKVLEKIVQSYSKNNKNLSYFFIICDENNTYCVLEVKEALKNKNVQADLFMKEIMKSVLGHSGGSKNKAFGSVEKDKGMVIKEHAEEMLKNINK
The following text describes a protein:
Function:
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations. Selectively binds single-stranded d(GT)n and d(GTT)n microsatellite repeats. Has much higher affinities for the homologous RNA sequences (GU)n and (GUU)n. Does not bind double-stranded DNA. Has a role in meiosis.
Miscellaneous:
MISCELLANEOUS: Deletion of both tsn1 and trax results in slightly stimulated cell proliferation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNKSIFIQLQDQIDKEHSIREKLTAEVDLLDEKLRVLQLLLANCEQNLENQEEILEALEIIKSKTRGLAELASNFPYYKYNGVWDRSIQKVVYLYLLASWTGRLDKSLRPTYSLLSLSEVGQILQVPVFPEESTFHLSIEQYLHAVLSLCSELARQSVNSVISGNYHIPFEALNTIQKVHSSFQVLSLKNDSLRRHFDGLKYDLKRSEDVVYDLRIHKLV
The following text describes a protein:
Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MGLLASITAATQTEYSHMDTSVKRAHNASLLWGTYRPNLYFGARSRTPETVLAGLMWFGISNLASKPWDNIRHSCEQDAGLAGYAWNKHSGRNFGDQTIIDKTNNVSIRTQFLKSADGTDWTVRISGTPLPDSTTADISLLFYAGLDGQGEITLDSYKTPSHQSDTDEDHHNRIARPLPLMVNGHTPLLGNFGLVFHQDPASKNAPPPISSTAAAMNLPDLRDPVLIKLALPEDQVWNIKDHVRNLLIQNAQTLISTYSKTQQSNIPLQNLLHLGKNSPLDAPGNIALYQQTFRSPFSIDIAFLSNPDTSHKSPISREDIDSSVGSKLSHSLINAESQFDVRFENTFHLAERGFSESEIGFGKMLLSNMIGGMGYFHGTSMVDRAWMDLDDGEEDDYFEGSVSQAPRPNPKLEGPTSLFTDVPSRPFFPRGFFWDSGFHQHLIGVWDNDLSLDVIQSWASLIDEDGWVAREQILGDEPRSKVPEEFQIQYPHFANPPTLITALMRYMNRLKTGRNSMESGVELDNPLFLANYHITSKHAATTYLGTIYPSFKRQYQWFRRMQWGQITEWGRSSTSQEAYRWRGRKGIHTLTSGLDDYPRSTEPHAGELHVDLLCWMALYSKTLGAISQELGMDEDAALFDKQHKDMLLSLEELHWDESSQTYTDLSVNAQGQSYHVVHKGYISLFPMMLGLLEHDSQHLGAILDLVESERDIWTPYGIASLSKSDPYFGTGENYWRGPIWINMNYLTLQSLFKNYMNKPGPYQQQAQRIYKNLRANVIKNVHEEYVKTGYVWEQYGATHGEGKRSHPFTGWTALVLLIMSEDY