lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the assembly of microtubule arrays in the germline acting redundantly with ptrn-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, and morphology and integrity of the epidermis. Required for microtubule stability and anchorage by binding to microtubule minus ends. Recruited to hemidesomosomes in early embryonic elongation to direct the nucleation and growth of non-centrosomal microtubules; [Isoform b]: Required for normal nuclear migration in the embryonic epidermis; [Isoform h]: Directs the assembly of non-centrosomal microtubule arrays that determine the position of nuclei within intracellular compartments in the epidermis and this is independent of ptrn-1 activity.
Subcellular Localization:
Cytoplasm, cytoskeleton. Apical cell membrane. Cell junction, hemidesmosome. Cell junction, adherens junction. Note=Isoform h: Co-localizes with gamma-tubulin to the apical cell membrane.
Sequence:
MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDRPKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNSSTPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLSQRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFSVDNRMSKYQKNQSLRQFLNSPVRLRKRGDTSRRDAVEAGFEPRDTVPRCHSTQSLRDVQRVRSYNNSQFQASDLSLNPNGSIRAACDSTSGSVAPTAVVNPARNHVISHRQQHHTSYEKDLIPHHNIDVDRRRSLQALNGSSALYQLNNGGSPNGVRSQFSPSDLSIHTPVHHVGSRVRVSSVNQICDSNSAPQFSIDQRRSVHNIGNPVRNSFVDGIKTTSTPKNQIAVAPLAHKSRHLSESRDEMRGGAERRGSGGQMNLPAYTNYLIRHSGEERLVDGPVTNASDARIAYLEKRIRELELTQKEQSSHSTPSQSRHSSSKSSHFNGSSNLSTSEQLRLQEMSDELANKDRKVTSLESKLLKAYQRIERLNEEYDGKIKNLMYDSERARDDLTRCVDKIQQLENELDETRAAVQNGDHANEQEYHELRDKIWKQERELQESRTLLTRLREKEAEFERMRSEKGYLELKNENLNKKLEAKKRAVEELERSVSTLRLEQTICQQSCSSGSTPLADEMEIMSDIRPSLARPYTKAHSTLGSHNMSPLSHSKSSGLTKSFSNFALNSSKQRDDITANMSRSIREQNRHITMCRAMVVCLKDTVDRMARGENPDVARLLGVKLNVMSESEMEDDEDHEADASQPFSMMSAESALSKQCGKLADLDKDLDTIRCQLADWHGQTNAEGDGDRDVCRVQ
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSFSTLYNTLFRRNSVFVGTIFASAFVFQTAFDSGITAWYEKHNKGKLWKDVKLQLQNGEDDDDDE
The following text describes a protein:
Function:
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MRPADLLQLVLLLALPGDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSFLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTRNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMQDVYELLENSHLTPKKQGQISEEYMQTVL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MQSARQRGPQLINLAIRFSNELASCGGVIGALRQGDAIRQGLAQQQRLISSALASHYGGLAQQLAESPIGLQGLRSFAAAASAQQQPQQQQPGGQKDKYDSLELTQERIDSITDKIPQRPVGVVEGTSYTVIILAAFGVLAFVLYQVLSSLIFEPTAITAFNATLERLKSDPRITVRIGEAGDIRAWGSNSESRVARQQIPHQIYKDQNGVEHVRIQFYIKGPSGTGQVNADMYKDPTGLWAYTYLLVDAYPASGAGSGPQRLTIVSPPR
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Sequence:
MAKKSSIEKNNRRKRMVKNAAPKRERLKAIIADKTLPMEERFAATLKLAEMPRNSSATRVRLRCELSGRPRSNYRKNKLSRIALRELGSKGMVPGLVKSSW
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Sequence:
MDVYGLIGNPVGHSLSPPLHAAAYDECGLDARYVTFEPAPDDAAAAIRGAGALGVAGLNVTAPFKQSAASAVATDSMAARVGAVNTIDFSGAAPRGYNTDVAGVKRAFAHHDVSLSGAQAVVVGAGGAGRAAAFALADAGATVRIANRTRAAADELAADVGGTAVGLGDLPRSLADATVLVHATTVGMDDPDTSPVSADALHDDLAVLDAVYSPVETRLLRDAAAAGATTIDGAWMLLYQGAEAFERWTGLDAPVAAMRAALRARL
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MAGEYGSVIGLVLWHRKFVCISGHQAVADALSNPALSGRPLSFDFLLRTKGLSRGVLMTEGELWKEQRRFTIKHLKDVGVGKSSLEGIILDEIRDLVTDINCSKDGNIMLDDVFTTSVINILWVMVSGTRFKRGDPQMDRLTSCMNGFMRYSNGGPNLLTVVPFIRYIAPELSGYNRLMQYIGPIRSYIEELVAEHRKTLQINAPRDFIDLYLENLIEKESSNNSSFHKEELLGIIFDIFVAGSETTSHTLGFALLFMIMHPHIQNKVQEEIDEVLHGGTPSLTDRGRLPFTEATLQEIQRLGVVAPLTVPHVAQQNTKCQGYHIPKGTLMFINLWSTNIDPQVWPEPNTFLPERHLNDAGKFVKSEKLLTFGLGKRSCIGETLARSTLFLFFVSMMQHFRFESPWNDVDLELQPSLEPIPGLTLAPRPCLARVVKRAL
The following text describes a protein:
Function:
Transcription activator that recognizes and binds to the DNA consensus sequence 5'-CACGCGC-3'. Activates the expression of FHY1 and FHL involved in light responses. When associated with PHYA, protects it from being recognized and degraded by the COP1/SPA complex. Positive regulator of chlorophyll biosynthesis via the activation of HEMB1 gene expression.
Subcellular Localization:
Nucleus.
Domain:
The FAR1 domain is involved in direct DNA binding, the SWIM-type zinc finger is essential for transcriptional activation activity and both the MULE and SWIM domains are essential for dimerization.
Sequence:
MDIDLRLHSGDLCKGDDEDRGLDNVLHNEEDMDIGKIEDVSVEVNTDDSVGMGVPTGELVEYTEGMNLEPLNGMEFESHGEAYSFYQEYSRAMGFNTAIQNSRRSKTTREFIDAKFACSRYGTKREYDKSFNRPRARQSKQDPENMAGRRTCAKTDCKASMHVKRRPDGKWVIHSFVREHNHELLPAQAVSEQTRKIYAAMAKQFAEYKTVISLKSDSKSSFEKGRTLSVETGDFKILLDFLSRMQSLNSNFFYAVDLGDDQRVKNVFWVDAKSRHNYGSFCDVVSLDTTYVRNKYKMPLAIFVGVNQHYQYMVLGCALISDESAATYSWLMETWLRAIGGQAPKVLITELDVVMNSIVPEIFPNTRHCLFLWHVLMKVSENLGQVVKQHDNFMPKFEKCIYKSGKDEDFARKWYKNLARFGLKDDQWMISLYEDRKKWAPTYMTDVLLAGMSTSQRADSINAFFDKYMHKKTSVQEFVKVYDTVLQDRCEEEAKADSEMWNKQPAMKSPSPFEKSVSEVYTPAVFKKFQIEVLGAIACSPREENRDATCSTFRVQDFENNQDFMVTWNQTKAEVSCICRLFEYKGYLCRHTLNVLQCCHLSSIPSQYILKRWTKDAKSRHFSGEPQQLQTRLLRYNDLCERALKLNEEASLSQESYNIAFLAIEGAIGNCAGINTSGRSLPDVVTSPTQGLISVEEDNHSRSAGKTSKKKNPTKKRKVNPEQDVMPVAAPESLQQMDKLSPRTVGIESYYGTQQSVQGMVQLNLMGPTRDNFYGNQQTMQGLRQLNSIAPSYDSYYGPQQGIHGQGVDFFRPANFSYDIRDDPNVRTTQLHEDASRHS
The following text describes a protein:
Function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Sequence:
QDFSDCAPSVALASVTVRPGSCPSTSPGWSPFSSRVFPPNVIMSVSNGAVKTPHKKARTSPYPGSKVDWQVEWPEYQPVAYTSDSILTRPKWADPLVGERNFSPKFNEKDGQVERRSQNGWYKVKNGRPRNPVGQTGLVGRGLLGPWGPNHAADPILTRWKKDGKGNKVTHPVSGRNILQFVAIKRKDCGDWAIPGGMVDPGEKISTTLKREFGEEAMNSLQKPRAEIQALEKQLHKLFSQEHFAVYKGYVDDPWNMDNAWIETEAVNYHDETGEVMDHLPLEVDINDKLKLYASHSQFNRRVSEKRGAHWREDVYPDCYG
The following text describes a protein:
Function:
Cargo protein of a type 1 encapsulin nanocompartment. A ferritin-like ferroxidase that mineralizes iron inside the encapsulin nanocompartment. Converts Fe(2+) to Fe(3+) that is released to the exterior of the decameric complex for deposition in the encapsulin nanocompartment. In solution the decamer binds 10-15 iron cations; in the encapsulin nanocompartment the decamer can bind up to 48 ions, perhaps via its internal channel and on its exterior. The empty encapsulin nanocompartment sequesters about 2200 Fe ions while the cargo-loaded nanocompartment can maximally sequester about 4150 Fe ions. EncFtn retains ferroxidase activity when encapsulated. Flux in the active site di-iron metal center is thought to be controlled by the 'entry site' of the protein, which both attracts metal and controls the rate of iron oxidation (Probable). Encapsulation in the nanocompartment does not alter either function of this protein.
Subcellular Localization:
Encapsulin nanocompartment.
Domain:
The decamer has negatively charged patches on its exterior, and a negatively charged tunnel at the center, that are probably metal-binding sites.
Sequence:
MAQSSNSTHEPLEVLKEETVNRHRAIVSVMEELEAVDWYDQRVDASTDPELTAILAHNRDEEKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAIEAADTAGEGSGGDAAKGATAQGDGSLGIGSLKGEAALARPPRL
The following text describes a protein:
Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Rescues alpha-factor maturation defects.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Punctate localization pattern. Localization affected by loss of SVP26, a membrane protein, and is shifted to the ER.
Sequence:
MSSQPSFVTIRGKAISLETQTESLLSKYSTFAQTTSSEQTGQEKKIDKQLEGILGQRQDVIDSLTQICDSNPAISASKLSQLHRHKEILQDHWKSFRNIRSSIQQERNRLNLLFSVKNDIANSTTDAPAPIGDADEYIQNETRRIDQSNNVVDRLISQAWETRSQFHSQSNVLNTANNKVLQTLQRIPGVNQLIMKINTRRKKNAFVLATITTLCILFLFFTW
The following text describes a protein:
Function:
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
Subcellular Localization:
Cytoplasm. Cell projection, lamellipodium.
Sequence:
MLGEGSSRGDSTPPSKHKGSKFSTLGKIFKPWRWRKKKSSEKFKETSEELERKMSTRRTRQELIEQGVLKEIPDNGGDAPNLKQSYVKNGHTLPVRVGGEVVSSVKSPSKPPTEPDYRKKPSWLSQPDDRKGHSPSDGVRRGALATRGTGLQEDGWRLGVMGPRSHAEGEWKSNLAWQGQIHRQMEEGRRGGRLHPEDGQRRPGLQKAPSEDGRRSRPTEGDWKPTLPRHASAEEGRAWRESDSHFLPDPEGVQDTLREPLPPKQSVIPPKWLISSTPEPGSEGSTRTLSNHPTTQYSSLSAVTSKPVRLVSSAGTSTQQVTLTSTSQAVKQPPVPPPKPMNRGNAGTLVSALQGGENAQLPLYWSCWKRECDYDVYLSLPVYLCRRAGGLRSGDFTQTTGGASHVAKPSPPMPPKRTTPITKRGIEDSALSPSPHSLEDHSSLSVGFQMPPPPSPPLPTHIPPSPPRQQIHSHHLHHQHSYPHPLPQPIPMLFDLPSPTNESPQHPAPVPLHIMIQRALSSPGPAQPHPDGLQRAHALLFETPPDYQGERGRPLPVSIQPLKLSEDDYSEEEDDEEEEEYDGEIPQPELEPRSRLCLIGDAGVCFLPGENGSEGEEVEEDEEEEEGEHHMREDDSDTDGPMLHKDEDEEDEPPPSALASKVNRKDTLALKLGSRSCVPDRDRFVQDGSSRDEQPHGQGLTWQSREQWEAIRTQIGTALSRRLSQRPTAEELEQRNILQPKNQADRQAEVREIKRRLTRKLSQRPTVAELQARKILRFHEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNDYKSTEMEVHEESRIYTRFHRP
The following text describes a protein:
Function:
Channel protein that mediates glycerol entry under ethanol stimulation. Does not seem to mediate glycerol uptake under standard conditions.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MSYESGRSSSSSESTRPPTLKEEPNGKIAWEESVKKSRENNENDSTLLRRKLGETRKAIETGGSSRNKLSALTPLKKVVDERKDSVQPQVPSMGFTYSLPNLKTLNSFSDAEQARIMQDYLSRGVNQGNSNNYVDPLYRQLNPTMGSSRNRPVWSLNQPLPHVLDRGLAAKMIQKNMDARSRASSRRGSTDISRGGSTTSVKDWKRLLRGAAPGKKLGDIEAQTQRDNTVGADVKPTKLEPENPQKPSNTHIENVSRKKKRTSHNVNFSLGDESYASSIADAESRKLKNMQTLDGSTPVYTKLPEELIEEENKSTSALDGNEIGASEDEDADIMTFPNFWAKIRYHMREPFAEFLGTLVLVIFGVGGNLQATVTKGSGGSYESLSFAWGFGCMLGVYVAGGISGGHINPAVTISMAIFRKFPWKKVPVYIVAQIIGAYFGGAMAYGYFWSSITEFEGGPHIRTTATGACLFTDPKSYVTWRNAFFDEFIGASILVGCLMALLDDSNAPPGNGMTALIIGFLVAAIGMALGYQTSFTINPARDLGPRIFASMIGYGPHAFHLTHWWWTWGAWGGPIAGGIAGALIYDIFIFTGCESPVNYPDNGYIENRVGKLLHAEFHQNDGTVSDESGVNSNSNTGSKKSVPTSS
The following text describes a protein:
Function:
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Sequence:
MENGEWKMENAMQQDGAQPTPNSRLSILDFSNFLIVANPLKALQKLAEAHRENFKIPVIGITGSNGKTIVKEWLHQLLSPDRCIVRSPRSYNSQIGVPLSVWQLNEEAELGIFEAGISEMGEMGALKRMIKPTIGILTNIGGAHQENFFSLQEKCMEKLTLFKDCDVVIYNGDNELISNCVAKSMLTAREIAWSCKDIERPLYISKVTKKEDHTVIAYRYLDMDNIFCIPFIDDASIENALNCLAACLYLMTPADQITERMARLEPIAMRLEVKEGKNNCILINDSYNSDLASLDIALDFLVRRSEKKGLKRTLILSDILETGQSTATLYRRVAQLIKSRGINKLIGVGAEISSCAARFEGTPERYFFPDTDALLRSGIFKTLHSEVILIKGSRVFNFDLVSEELELKVHETILEVNLGAMVANLNHYRSMLRHPETKMICMVKAAAYGAGSYEIAKTLQEHHVDYLAVAVADEGSELRKAGITSSIIIMDPELTSFKTMFDYKLEPEVYNFHLLDALIKAAEKEGITNFPIHVKLDTGMHRLGFSVDEIPLLIRRLKSQNAVIPRSVFSHFVGSDSAQFDFFTRQQIELFEKGSQELQEAFSHKILRHICNTAGIERFPGAQFDMVRLGIGLYGVSPIDNSIINNVSTLKTTILQIRDVPGEDTVGYSRMGHLTRPSRIAAIPIGYADGLNRHLGRGNAYCLVNGKKAPYVGNICMDVCMIDVTDIDCREGDKAVIFGDDLPITTLSDKLGTIPYEVLTSISNRVKRVYYQD
The following text describes a protein:
Function:
Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn2 kinase activity; impairs gcn1-mediated gcn2 activation, and hence gcn2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis. In normal conditions, it resides in a actin complex and has no activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MENNEEFQDELLALESIYPSCLLPISEQSFTYTLSIPDSSVRLNIQFPLDYPNSAPTVLDAYGIDKTLAEDVLLSVATGDVCIFSYMDLLKELVDIDAEQAAAERESKLQEESDKETPVMLNKSHYVAKTPEIQDEPWKPKFDWKESEPITDRKSTFMAHATRVYSTEEVREALEDLYMDKKVAKANHNMVAYRIISPNGNVIQDNDDDGESAAGSRMSHLLTMMSAENVFVCVSRWFGGVHIGPDRFKHINSSAREAVLLTDAAPSQKKGTEHGKKKKK
The following text describes a protein:
Function:
Intracellular G-protein coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine. Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine (By similarity). Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin (By similarity). Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand (By similarity). CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity (By similarity). T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (By similarity). TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes (By similarity).
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes mainly intracellularly. Partially colocalizes with the endoplasmic reticulum; also found at lower lever at the plasma membrane.
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
The following text describes a protein:
Function:
Essential virulence determinant; cytotoxic effector, involved in resistance to phagocytosis.
Miscellaneous:
MISCELLANEOUS: N-terminal is important for export, C-terminal is indispensable for virulence.
Subcellular Localization:
Cell outer membrane.
Sequence:
MKISSFISTSLPLPTSVSGSSSVGEMSGRSVSQQTSDQYANNLAGRTESPQGSSLASRIIERLSSVAHSVIGFIQRMFSEGSHKPVVTPAPTPAQMPSPTSFSDSIKQLAAETLPKYMQQLNSLDAEMLQKNHDQFATGSGPLRGSITQCQGLMQFCGGELQAEASAILNTPVCGIPFSQWGTIGGAASAYVASGVDLTQAANEIKGLAQQMQKLLSLM
The following text describes a protein:
Function:
May be involved in inflammation.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDSSSYGLLQYFQKLSDEEFQRFKELLQKEQEKFKLKPLSWTKIKNTSKEDLVTQLYTHYPRQVWDMVLNLFLQVNRKDLSTMAQIERRDKQNKYKEFMKNLFQYIWTSETNTYMPDRSYNTIIDRQYKALLDIFDSESDPATAVVLGTRGKGKTVFLRKAMLDWASGVLLQNRFQYVFFFSVFSLNNTTELSLAELISSKLPECSETLDDILSNPKRILFVLDGFDYLKFDLELRTNLCNDWRKRLPTQNVLSSLLQKIMLPECSLLLELGESSCSKIIPLLQNPREIIMSGLSEQSIYFYCVSFFKIQLGVEVFKDLKKNEPLFTLCSNPSMLWMICSSLMWGHYSREEVISSSESTSAIHTIFIMSAFKSIFGLGSSKYKRFKLKTLCTLAVEGMWKQVYVFDSEDLRRNKISESDKTVWLKMKFLQIQGNNIMFYHSTLQWYFATLFYFLKQDKDTYHPVIGSLPQLLGEIYAHKQNQWTHAQTFFFGIATKHVITLLKPCFGNISFKTIRQEIIRYLKSLSQPECNEKLVHPKKLFFCLIENQEERFVSQVMNLFEEITVDISDSDDLGAAEYSLLRASKLKNLHLHIQKKVFSEIHDPEYGSLENFKLDQKFSAINWTMLSILFCNLHVLDLGSCHFNKKVIEVLCNSLSPTPNMPLTVFKLQRLLCSFMTNFGDGSLFCTFLQIPQLKYLNLYGTDLSNDVVEMLCSALKCSTCRVEELLLGKCDISSEACGIMATFLINSKVKHLSLVENPLKNKGVMFLCKMLKDPSCVLESLMLSYCCLTFIACGHLYEALLSNKHLSLLDLGSNFLEDIGVNLLCEALKYPNCTLKELWLPGCYLTSECCEEISAVLTCNKNLKTLKLGNNNIQDTGVKRLCEALCHPKCKVQCLGLDMCELSNDCCEDLALALITCNTLKSLNLDWNALHHSGLVMLCEALNHKKCKLNMLGLDKSSFSEESQTFLQAVEKKNNNLNVLHFPWVEDELKKRGVRLVWNSKN
The following text describes a protein:
Function:
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Plays a role in the senescence-associated cell size enlargement via SFK/PI3K/Rac1 and thus promotes senescent cell survival. Also participates in the innate immune response by acting as a ligand for the receptor TIGIT to inhibit NK-cell activity.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Colocalizes with AFDN at cadherin-based adherens junctions.
Sequence:
MPLSLGAEMWGPEAWLRLLFLASFTGQYSAGELETSDVVTVVLGQDAKLPCFYRGDPDEQVGQVAWARVDPNEGIRELALLHSKYGLHVNPAYEDRVEQPPPPRDPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARMRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTQSSRSFTHPRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDRRITHTLQVAFLAEASVRGLEDQNLWQVGREGATLKCLSEGQPPPKYNWTRLDGPLPSGVRVKGDTLGFPPLTTEHSGVYVCHVSNELSSRDSQVTVEVLDPEDPGKQVDLVSASVIIVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRTEEDDDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV
The following text describes a protein:
Function:
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (By similarity). Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (Probable).
Sequence:
MINLKELKILHTSDWHLGVTSWTSSRPVDRREELKKALDKVVEEAEKREVDLILLTGDLLHSRNNPSVVALHDLLDYLKRMMRTAPVVVLPGNHDWKGLKLFGNFVTSISSDITFVMSFEPVDVEAKRGQKVRILPFPYPDESEALRKNEGDFRFFLESRLNKLYEEALKKEDFAIFMGHFTVEGLAGYAGIEQGREIIINRALIPSVVDYAALGHIHSFREIQKQPLTIYPGSLIRIDFGEEADEKGAVFVELKRGEPPRYERIDASPLPLKTLYYKKIDTSALKSIRDFCRNFPGYVRVVYEEDSGILPDLMGEIDNLVKIERKSRREIEEVLRESPEEFKEELDKLDYFELFKEYLKKREENHEKLLKILDELLDEVKKSEA
The following text describes a protein:
Function:
Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. Plays a role in regulating dopamine-mediated locomotion behavior.
Subcellular Localization:
Cell projection, dendrite.
Sequence:
MALPRLRVNASNEERLVHPNHMVYRKMEMLVNQMLDAEAGVPIKTVKSFLSKVPSVFTGQDLIGWIMKNLEMTDLSDALHLAHLIASHGYLFQIDDHVLTVKNDGTFYRFQTPYFWPSNCWDPENTDYAVYLCKRTMQNKAHLELEDFEAENLAKLQKMFSRKWEFVFMQAEAQYKVDKKRDRQERQILDSQERAFWDVHRPVPGCVNTTEVDFRKLSRSGRPKYSSGGHAALAASTSGIGCTQYSQSVAAAHASLPSTSNGSATSPRKNDQEPSTSSGGESPSTSSAAAGTATTSAPSTSTPPVTTITATINAGSFRNNYYTRPGLRRCTQVQDTLKLEIVQLNSRLSKNVLRTSKVVENYLAYYEQRRVFDPLLTPPGSQADPFQSQPNPWINDTVDFWQHDKITGDIQTRRLKLWEDSFEELLADSLGRETLQKFLDKEYSGENLRFWWEVQKLRKCSSRMVPVMVTEIYNEFIDTNAATSPVNVDCKVMEVTEDNLKNPNRWSFDEAADHIYCLMKNDSYQRFLRSEIYKDLVLQSRKKVSLNCSFSIFAS
The following text describes a protein:
Function:
Required for the maintenance of phospholipid turnover within the photoreceptor.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MQQQQQPSIDQLPEPTASTSNSATTKPTIATATTSTTTTSGNNFHQQLQATTAATMQRLRTTFTRSRTPTGAEMKMQNSLEVPKQVRSASFDEMQLESQRASSSLLKQQSSSSASADERSSEAGFLQVPLAAHQQRSHSFDSATASAGSDDSGTFLEVPRRLKARRSSSTKTPPPCIHCHYLEEYERRMTAEQRYFIDHRELTALSYSNTSSEASEDEDEVEGHNAEEEEEGSAAIEDAEEETTEAATEEADEDPRTEVESEHDHDPDDDAALEMDIRIGNMSQGSSIEESRARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQPTTPCGITFTLSPTNGDYPSPPHLPLDPGSPPISPCSSNSGRLPALAPIISTPCSSADADDAGAAMGLPVRARRRSISRQEAIFVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEASTMATCGSPGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYWKPTSASGDLCCLNEECIKSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDSFGASKPSIDDGLMEVVGLTTYQLPMLQAGMHGTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRGDVQVNPLEKMQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEESISYPKVSQDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILDHEAATMPQTPDQERSFAAFSQRQAQNERRQMDQAQGRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYNHRDIVKYIIASATRRLINMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNANEIATYLESKQGTQPVDGWLDD
The following text describes a protein:
Function:
Probable transporter.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSLSSLEHKLTYHVRNWLHGSGFAWNTLHMSAFLVALCACIPAGFISQISLYSEPWREHLGYSVVEVNVLFSAVNLGGYITPPLLGLLSDAHGPVMLSWLSFVGFVPTYAYAAWVFASGEPHFYASVLCFTLIGISTNALYFSALFTASKLYPASKLCSISLPATFYGMASVLGSQLLKIPWFRNGLPYLDLSRVFRTLAVAYTLISFCMWFATSIVTMLKVKAATLTFAGMQSPTEPLLPQDIRRRLRNFFHDPAAYFMALVLLLSLGPMEMFLTNMGSLSSLLGQASVLPEFAIASTCSRFLSGLIIDLCIHNGVSTMSVQWAVLLLGVVGQWIVVLATRASDGPLLSLASALSGACYGGLFTVSPILTLAVWGDAVFGTAYGSFMITPAVGSILFGLTYAHIFDANCTPSGVLPVCIQHVFWSSTSALAIALLFSVLMYLVFWRRKV