lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALNKSMHVRNRYKDKPPDFAFLASKYPDFKQHVQINLSGRVSLNFKDPEAVRALTCTLLKEDFGLTIDIPLERLIPTVPLRLNYIHWVEDLIGHHDSLKNTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKVPQKTLLMDALKEESEIIYDFCMCNPPFFANQLEAKGVNSRNPRRPPPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRIQGVPKVTHTEFCQGRTMRWALAWSFYDDVTVPSPPSKKRKLEKPRKPITFLVVESVMKELAVKALALGLDAVGGIAVVTTWIEKILTDLKVRHKRVPCGKEEVSLFLTAVENSWVHIRRKKRDRVRQLREVPRAPEDLIQAMGEGRNLPKEAESCCPEEEPRQEENSPADPRGTAGDQVSPRGSSPEDKDSPAQEISEKALKEEEEEEVEEGSGGGDAVQEGPDALGRSRVSGDAAEEPEAPEEVGDSAAGREKRPEGGGNGQFLFKCLINVKKEGEAATVEMHWVEGQNRDLMNQLCTYLRNQILRLVAS
The following text describes a protein:
Function:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Subcellular Localization:
Secreted.
Sequence:
MRAQPPPRTLLSLALALLFLSMSWAKRGCSSSSPKLLSQLKSQANITGNTASLLEPYILHQNLNTLTLRAACTEHPVAFPSEDMLRQLSKPDFLSTVHATLGRVWHQLGAFRQQFPKIQDFPELERARQNIQGIRNNVYCMARLLHPPLEIPEPTQADSGTSRPTTTAPGIFQIKIDSCRFLWGYHRFMGSVGRVFEEWGDGSRRSRRHSPLWAWLKGDHRIRPSRSSQSAMLRSLVPR
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Sequence:
MQTYIDYRKAQKPLNLDNFIVEIGFGSGDFLIALAERNREEIFFGIEKSWIPVNKLLKKCKLREINNIYCTRLDAYWAFQLLFKDKSVKMIIMNYPDPWFKKSHVEKRLTKRENLFIYAKKLIPNGEIKIRTDDYPFVEFTLQESNFLKCFSTSISNPSINEPLTKYEKKWLSMGKSIWDIVLKKEKEPALIEVKKITEVKELFPVKVFNKELNINAISHKEFKIEEGLYLKCFSVWKRNQDYAIEVVLSEKDFLQAFLITAKKKDEYFIIDVSQFSEILKTEGVQKTLNFLANLFVEAL
The following text describes a protein:
Function:
May control G2/M (mitosis) phase progression. Plays a role in regulating seedling growth in darkness via regulation of hypocotyl cell elongation and cotyledon cell development. Plays a role in stomatal development. Required to suppress endoreduplication. Together with CDKB1-2, promotes both the last division in the stomatal cell lineage as well as the number of stomata. In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage.
Subcellular Localization:
Nucleus.
Sequence:
MEKYEKLEKVGEGTYGKVYKAMEKGTGKLVALKKTRLEMDEEGIPPTALREISLLQMLSTSIYVVRLLCVEHVHQPSTKSQSTKSNLYLVFEYLDTDLKKFIDSYRKGPNPKPLEPFLIQKLMFQLCKGVAHCHSHGVLHRDLKPQNLLLVKDKELLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTGVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTEQQWPGVSTLRDWHVYPKWEPQDLTLAVPSLSPQGVDLLTKMLKYNPAERISAKTALDHPYFDSLDKSQF
The following text describes a protein:
Function:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTKSKPPRISLPFAAISRKSDFLLGASFSCIHVLLTTIVYHYVPEPYMDEIFHITQTRSYCSGNYSWNPLITTPPALYVISMPLCGGNERYANSILLFFAIPAFCRFRRMFVRQDVWLTASIVGMLPILISSSILFYTDLLSLTSVIWGFSIGNPIASAFLFLISILTRQTNIIWAAIYAFSVIASRIDKSRSKMENLKIIISTAFSLWPFITLAIGFAMFIYFNDFQIVLGDAKAHQPKFHVAQFFYMVAFCAAHTWTQIIPNLLSHLRHLTDMKSLVLQAVVAVLVYYYSYDHPYLLADNRHFTFYIWRRFLANPTMRTTLAPLYVFSLRFMTTSTPSVHIFHKILFIIASLLVLVPAHLFEMRYYIIPYVLWRLSTVNNSRKSLLFLEIISQAVIFAAVFVLFLFKTFEWSNEPGVKQRFMF
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MDETTNGRRKAIVTKQPHGDADSIELRNWATPSSSSKEGSASNHNRRIQRALQDLQGVDEINIRQTLETIGSSCTGSNAYHLVTREGDVLLNAFEETTCCSRCWCGPARSFRMSIQNAESEEILQVVRPHRCDACCCPCCLMKSMVQTPGGYVLGYTKQNWSLCGAVFTIINRNGHRIAGMESPCCPCRCCTNIDISILSRNGEEGAVTKRWGGRKHNTNMDHEFFVLNFPSGTDLQTKGLLLGSAFLVDYMFFEMT
The following text describes a protein:
Function:
May only reduce GSH-thiol disulfides, but not protein disulfides.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKVMRMSSEKGVVIFTKSSCCLSYAVQVLFQDLGVNPKIHEIDKDPECREIEKALMRLGCSKPVPAVFIGGKLVGSTNEVMSMHLSSSLVPLVKPYLC
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MGNSSSITKPEELVRFRKLNTSFDDVDIPARPENRTLTDKKGFVIFGICILLLLPFVIYALTKSDLRHLDSGYDDCGNFCGYQNEKIEGISCSGKDYTAQPFSDNLKCVTQCPKDSLAGVCVDEEAQLDDIVEDSDFTETGSIVWRFIVSILITISLSIVVLVLLRFIPAIVVWSCLVLTVLMLIAITFILWFSVARAKDVNKGDFEEFSRNGVKFDVLTPLTALASIWTIIALVLIIIIAVVFKKIKLVILLFKEATKALAAMPMLMLIPVTVTIIQFIVIVLFIVTTIYILAARQLVRLENGLYYYEVNGVIIFAFVFNLVMLNYVARFFAGINYMVISGSVSSWFFTRNKEYLGSPILTSVSNTFKYHLGTVAFGSFLMLLFGFVKMIIKPLCRNACCRCICMMCCTYVDILFQFLSENAYIETGIHGQSYLRSAKRATKLLLKNAKSVIAINCVGDFVLGIIVFLLAIVTSVISSTLFASSGPIYVYGPICFIINLIIVVITFGVFQIIIDTLFICFCEDSVINDGISRPFYMTRGLMEFVEHSKKLYGEKY
The following text describes a protein:
Function:
Catalyzes an anti cycloisomerization.
Sequence:
MPSHITESRIHGGAYSSPAFAAIFSDTNQVRRWLDVERALAATQAEMGIIPHEAAREIDRAAQVERFDLTQLGRESLETGHLLVPTIRALARSCEGSWGEYVHYGVTTQDILDTGLMLQVKEAWGHALGLLHSIRGHLLALALRHQHTPMVARTHGQQALPTTFGYKVAVWVDEIDRHLARFDEARERVLVGNLTGAVGTLASFGAQGFELQRRTLARLGLGAPSTSWHSARDRVLEVAGLLVQVSVTLGRVANEIYHLQRSEIDEVREGSRPGQVGSSTMPHKRNPSSVDLVSALSRLVRAQMVALTDAAFQLHERDGTAWRIEWAALPELFVYAGALLTRMEAVLAEGLEVREERMRANLDLLGGLILSERVMLALAGQFGKQTAHELLHEITQASQRQGVPFREALLGQPRLRGCFSAEALEELLDPVGYVGLAAEMVDLVADKPRTGASGDRPEGAASSQGNPGQSQYVMEDR
The following text describes a protein:
Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subcellular Localization:
Secreted.
Sequence:
MALWTRLRPLLALLALWPPPPARAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCASVCSLYQLENYCN
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MKVTKPNWVEHTVGEKKAKTAIYSISVHPDGTRLATGGLDHKVKIWSTLPILDVEAEKEEENPKLLCTMSSHTGSVLSVRWAHHGRFLATGSDDQVIMIWGLDPDGGGRLWGSDEINVENWKALTRLVGHVADVVDLAWSRDDTMLASVGLDSTVWIWDGLTFERLRKLDLHQGFVKGVCWDPVGNYLATQSDDKTVKIWNTEDWSLAETISKPFETSPQSTFFRRLSWSPDGAFIAASNAMNGPVFVAAVIDREGWASDISFVGHENTIQVAAFNPRLFFPEGEPKGRATASSMLALGANDFSISIWRNTLYKPLVVLKDIFGADLMDLCWSNDGYVLYGSSVDGSVCAIQFEPSEFTDLADFSATELVLREYDYKPKRAHQPLAVHSSAASITNGFGPSTTTSTHVNVLQPKKGKAKRRVDLSNGNINAGPSAGPSRQALRPPPPVDPFSGPIQGFASPSTAQASTARMFEDAHRAFGPGSGSISGTSPRAGDKRKASGSYEDPTRGVRGRGMPVQQPIQQFEVQIIRAPMVAPSPSDAGPSKAYLPYPQVQSILRAQAIGNESRSIYLEARNTSDPKGENVLCYFADGEQRWMDYLPKAALAVTVTKNFCAAACEDGSLRVYSPAGRLILNMKLSGLVYDLQGEDKMLLIITMDCQVRVINVRNGKAFSPPSSIHHLLFPGSSSFHSFDIISCTVRPNGVPVIITSEPQAFAYDASLHEWSTIASPPIAGIQPLPSGPSGPLSVVDQIVAKSAPVTTTEKSNAPWIEESYVMSQFEMKLRGTVLLDSKEEHKHWLLGYMKYLGDENFAERAGEVMKDLIGPVYHQSKPTGWEPKLLGVDKREIAAEVLDVLSKTLQGKNVASVWYDVLDKMKADEGSW
The following text describes a protein:
Function:
Virulence factor that regulates vesiculogenesis. Acts by regulating the production of mycobacterial membrane vesicles (MV) bearing Toll-like receptor 2 (TLR2) ligands, including the lipoproteins LpqH, a major host TLR2 agonist, and SodC. By restraining the release of most of the material that activates host cells through TLR2, VirR reduces the immunostimulant potential of M.tuberculosis and increases its virulence. May contribute to cell envelope integrity; When overexpressed in M.smegmatis, it modulates the production of IL-10, IL-12 p40 and TNF-alpha by RAW264.7 macrophages and it decreases the killing of M.smegmatis.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Subcellular fractionation and topologic analyses suggest that VirR is located in the cytosol, where it is associated with the plasma membrane without crossing it.
Sequence:
MLVTVGSMNERVPDSSGLPLRAMVMVLLFLGVVFLLLVWQALGSSPNSEDDSSAISTMTTTTAAPTSTSVKPAAPRAEVRVYNISGTEGAAARTADRLKAAGFTVTDVGNLSLPDVAATTVYYTEVEGERATADAVGRTLGAAVELRLPELSDQPPGVIVVVTG
The following text describes a protein:
Function:
Required for cell cycle progression. Has a role in the completion of START.
Miscellaneous:
MISCELLANEOUS: Present with 1940 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRLPRLYQRYLLYLVVFVVIALFYFLQAPRVEEHIGFDLALPISHVDNLWFQNKGLEGFSNDDKLVVNIGYDECFHIGRFYEGCFNRHELKSTLTDGHQYLQRKRIHKDLRGSFGRRWFGKSEYLYYDVLYPALVDYFGSNLEKLNVEAVTGISKYPKDKSLPFMDVSITFEPISIELLQKRSYISDINILFGVDCIQPIANWTLQKEFPLVKYRYSEPAYLTYKFVGTRPVDTGAQRLQETDEGKFKIVQLADLHLGVGESECIDEYPKHEACKADPKTETFVQQVLDIEKPQLVVFTGDQIMGDRSIQDSETVLLKAVAPVIARKIPWAMVWGNHDDEGSLTRWQLSEIASVLPYSLFKFSPHDTHDNTFGVGNYIYQIFSNNDTEVPVGTLYFLDSHKYSTVGKIYPGYDWIKESQWKYIEDYHDVNLKFKTGLSMAFFHIPLPEYLNIESKTHPGEKNPLIGMYKEGVTAPKYNSEGITTLDRLSVDVVSCGHDHCNDYCLRDDSTPNKIWLCYGGGGGEGGYAGYGGTERRIRIYEINVNENNIHTWKRLNGSPKEIFDFQSMLDGNSPESV
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSQHINNTKKKDSLCNNLFNQYVDNFDINLFSTSQISKSNGGTTTTSSTTNNQLNQVKSAKGLPNEIFITKKGIFVYKNNNNSGNFKNTTPTNTELCGECMNTAGPSTYTPVCTHKKSVVQHQTGYGNFDTINFSKDQSRQKPITSDSYKHIIIGGFTERFIKKFNLNSKCVTFTLKELTEEYFSNPLQWLKKAIDELLNYLGNDFQPEDIIGITMNNESFPQKPLGISFRKFSEISSDVILNVIGAVLQSNSTFFSNDQLEIRVDRVRLPTGRGFSALDGKCVTLSKAQKKKKGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
The following text describes a protein:
Function:
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
Sequence:
MAAAEQEKVVVVFRATGGAPILQQSKVKVSLDSRLSKLVLFLRKQLKTDSVFVYLRESFIPCMDDEVALLTQAYGIEGKLHVSYALTPAWG
The following text describes a protein:
Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination.
Subcellular Localization:
Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell junction, adherens junction. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Colocalized with SIRT2 in internode region of myelin sheath.
Domain:
Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization; The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids.
Sequence:
MKVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASFTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALTGLSTSVSDNNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNARSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRARVIWFHVVPAANKEQYEQLSQREKNNYSPGRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPAAPALAPPSVLSTNVGSVYNTKKVGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQTPKETKAEDEDVVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVARRISRCNELRSPGSPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNAALSRIMGKCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSSSSHDDVGFIMTEAGTWAKATISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLVADETKLNTVDDQRAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSYSLERQMNGDPEKRDKTERKKDKAGKDKKKDREKEKDKLKAKKGMLKGLGDMFRFGKHRKDDKMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELLYGGMSSYEGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPGDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQSGRHSVSVEVQVQRQRQEERESFQQAQRQYSSLPRQSRKNASSISQDSWEQNYAPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQLKKQPPADGVRGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
The following text describes a protein:
Function:
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
Sequence:
MAAHLLIVDALNLIRRIHAVQGSPCVETCQHALDQLIIHSQPTHAVAVFDDDARSSGWRHQRLPDYKAGRPPMPDDLHNEMPALRAAFEQRGVRCWASDGNEADDLAATLALKVTEAGHQATIVSTDKGYCQLLSPGLRIRDYFQKRWLDAPFIEKEFGVLPRQLPDYWGLAGISSSKVPGVAGIGPKSATQLLIQFQNLEGIYAHLDEVPEKWRKKLETHKEMAFLCRDIARLQTDLHIDGNLQQLRLAR
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MSESLSYCLDQIKESADSIATLYFKPPGIFQNALVHNSKTSYAEIITRLIRDADPVDEMSLYMTDKGGKLRRKDGKQGVYDHLTERAATLKRARLLGAPEETPIVHVPKEFYLKQHDIITKKKQRQNRDFLFDEFSKESGGMFEVLIKKFAGDQQVRNLLLALQNGSVITGEDASSRRKTMFVEDFSVELILRLLREIVTQWPLNEHRTKYEHLLQTYHDISDATNKLRAQIADQEHRLQSQDALSEEPDADDDDVAHPTSGVSYLIQQELDEIDALERELEQLRRDSRT
The following text describes a protein:
Function:
One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. confers responsiveness to glycerol and is required for feeding preference for beer and other sources that have fermenting yeast.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MARTTGDPAKRRRCMSRIKFWRRSRVGSEVVEKDTKRFKLSLIKAWLLRIRQEDYKYSGSFQEAIKPVLIIAQIFALMPVRKVSSKFAEDLTFTWFSVRSYYALVTILFFGVSSGYMVAFVTSVSFNFDSVETLVFYLSIFLISLSFFQLARKWPEIAQSWQLVEAKLPPLKLPKERRSLAQHINMITIVATTCSLVEHIMSMLSMGYYVNSCPRWPDRPIDSFLYLSFSSVFYFVDYTRFLGIVGKVVNVLSTFAWNFNDIFVMAVSVALAARFRQLNDYMMREARLPTTVDYWMQCRINFRNLCKLCEEVDDAISTITLLCFSNNLYFICGKILKSMQAKPSIWHALYFWFSLVYLLGRTLILSLYSSSINDESKRPLVIFRLVPREYWCDELKRFSEEVQMDNVALTGMKFFRLTRGVVISVAGTIVTYELILLQFNGEEKVPGCFEN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MYQFPGNFRTMSKNNRQKAGVKSASSHMAADLLSHGNMVTFDIFSGGATSMIDTEDAVSIKKLAKRDSSTREKALRELIDRCTEENANTVSSTFFNFSSIFERIIFDPSPIVRQLAMKLVSKQVNLLKKKAEKDLFNMLHWIVFATCDPYSQVSQEANTFITNVFPKDKWEEIMKRLTEKIIKILEEILVSGESTILIPSKLMNNDEDDCKEKRMNRLSEQSYGVLVTIIKGEKREEAQNILRHKLSNIKKNEMTRGLLNAVYNCIDPVSIISSCSLFDRLLSLFSSSDQSSLLPLSSDLLLLYLTSTTIILNDNQKKKVENTLISFLKKCGVCEWNCIGVRLLPLFSSLCGMMDESSRPIFISNWFNAIQSNGILTKECILYIGDCIKYVLALLENPSPQEISTALSMIFFLISQCSSSDPFTLHSLIIWTIPRLNQSKIPYFLEEVLRKCVESLPSSRPLINSLLSLHSDHLFFAWKFLHSSGMQSLPIHLLQNAPDNVLISLNESMNLIERIEEMGDASLSPLYIRLSSLIPSSSLERDITLPYSPLIHAVLTSINDDSQFIQLAGQLSDIDDYVEELTKKELTLPITRLHKLMNENERKKIERKILSIDSSFQFLANVAVSSKFSDEFDREVAIRVFNGYLAKTFDETKGIYMSEESRSIVNRLDITSILRIITDHVINSSRPIKVSFFHSIATLLYDVIEHGMNILDESLFFPHVISLLSCANEELTHYSLLSHFWPCCNELPYGPDPSSNLSIIMGRLNKMLALFLALYVHRSSDCSSSILLLSITMLSSSIKLARSYPLSFIAPSETENELLSYSNEMIENGGEFVKSEDVVSLLSYSTPISRPLIIYSLRPLTQSLKIGSLPYEADTPFSSLPTQSFNLHLEMARQLYYGRNVDIALETILSHSQLEGTPSNDQLFTLECDEAHFSLSISALTGANELMSGKRYGELERERDDDSRRSFSDPVIDFLRCAIVTALNSVDCYCPSQSKWEEGRRRLLAAASIQLAIRMNEMRAEEWVHFFLPSITPIILKIYGEIDVVDGSCLSRMVNIFISSHPSLEWNQSWNGQCDKKSFRYNMEMDEAGIPSAIQTMVVRAQNALERANEDKGEVIVAASILIGMCASFTISFSQDEENGIKVVLPPFMKSLASQDGDGWSRCAVLVAAIKLIDSEGKKEEEKDKKGAEKSIICDAMAPIITKCLTTIVSKTEHNSQHINSRYYIDKAIPSNDYLLHWLAYLLRETFSTFPSIVKMWYTALPKSAATLVNGFVCCHLSSILIDDEITQVMEGNLQEKYKNDQATLTIRRHANEILLDYILEDTRMRLCIKMPIGWPLIAPFVSVEGSIVGVEDGRKWMLQLNTQLHRNASVLSALTAWLIHAGKKVEGADSCTICMMLVAPTTKQLPKARCRTCHNKFHSSCLYKWFESSNQSQCPLCRADFTAPP
The following text describes a protein:
Function:
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Sequence:
MKRPYDALMPLPKAELHLHIEGTLEPELAFALAARNGVSLPYADEDALREAYRFADLQSFLNLYYELMAVLRTERDFEDLADAYLARAAAQGVRHAEIFFDPQAHLARGVEMGTVVEGLWRALGASRENHGVSTRLILCFLRDESAESAMRTLDAAGPYLDRITGVGLDSAEVGHPPVKFREVYEAAAALGLRRVAHAGEEGPPAYVVEALDVLGVERIDHGLRSVEDPALVERLVRERVPLTLCPLSNVRLRTVDTLADHPLPAMLDAGLMCTVNSDDPAYFGGYAGDNFDAVRQALGLTGERLRELARNSFLASFLEDDEELRARYLAEVEAYRFPAA
The following text describes a protein:
Function:
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains. Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular Localization:
Secreted. Cell membrane.
Sequence:
MEFGLSWVFLAGILKGVQCEVQLVESGGGLVQPGGSLRLSCAASGFTFSNSDMNWARKAPGKGLEWVSGVSWNGSRTHYVDSVKRRFIISRDNSRNSLYLQKNRRRAEDMAVYYCVR
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MKNIKLKLEYDGANYCGWQKQKNEKFITLQGTLEKAISNITKEKIEVIGASRTDSGVHARGYICNFFTNTKIPPENLQKVINNILPPDIVVLSSEEASSEFHSRFCSKGKTYEYTVLNSSKPIAIGRNYIFQFKDKLNIDNMKMASRYFIGTHDFSAFKTKGSSIKTSVRTISKFEINKKGDFIKFIITGDGFLYNMVRIIVGTLIEIGLNKREPEYIKYVIKSKDRTKAGKCVPSSGLCLKEVFY
The following text describes a protein:
Function:
Catalyzes the production of hydrogen sulfide (H2S) from cysteine. Can accept both D-cysteine and L-cysteine as substrate.
Subcellular Localization:
Mitochondrion.
Sequence:
MKVQRSTFLAVTGKSNLHHFHSSSQRIPITSEIDSREFVSKLLDRKWGLQCPASPIQQISVSSVKGIDKFSFLNNTRPHLGDEMSKSKQGSSFYILRDDLLHPLVNGNKARKLDALLPLVEDHKVTDLVTCGGCQSAHTAAVAVSCAERGLRSHLLLRGEQPDVLTGYNLVSTMYGNVQYVPRSRYANREEMLRTYADLVAGEDGTVLWAKDIVEGRDTMNVAKMDDFSSMKTSRRKVLIVNEGAGDALALLGMFRLVQHLSQDHLLGKKRPVKFVVDAGTGTTAVGLGVAAMSLGLPWEINAVMLADTLKNYKRHEDHLIAEFSRQFPGSVFCSGLDMNQMIKWIDRQHPRKFGKVLEGEVEMCRKIAQETGVLVDPMYTLAAWETATELVQDEKSSIVVMLHTGGTLGMFGLAQRYKTCFTNLKD
The following text describes a protein:
Function:
May have a second function in addition to protein synthesis.
Subcellular Localization:
Mitochondrion. Cytoplasm.
Sequence:
MPLSLWRLAIGSSRRHSLLKITSTRVLPVPRPYSTYSNNKKVIMPGEDQPAAAPAAAPAAQDAPGAPAPKKNDKKEKAKADKAAKFAAKQAAAKAKQPAAQSAPKEKKEKTPALPPYEDSTPAGEKKVIQSFEHPHFSAYNPSAVEAAWYQWWEKAGYFKPESCRKPSAGKFVIPLPPPNVTGALHCGHALANSLQDTLIRWYRMKGYETLWVPGCDHAGISTQSVVEKMLWKKEKKIRQELGREKFTDLVWEWKGEYHQRINNAQKLMGGSMDWSREAFTMDKNLTAATMETFCRLHDEGLIYRSNRLVNWCTHLNTALSGLEVETKEITGRTLLDVPGYDKKVEFGVLTHFKYQIDGSEETIEVATTRPETMLGDTGIAVNPEDPRYTHLVGKFARHPFVDRLLPIVTDNYVDKEFGTGAVKLTPAHDFNDYQLGQRHNLEFINILNENGTLNDNAGPFKGQKRFDARYTVVEELTKLGLFVKKEPNPMKIPLCEKSKDVIEPMMTEQWWVRMKEMGEAALQVVEEGKVKISPESATKSYKRWLADIQDWCISRQLWWGHRIPAYRVIFEGEEGQRENEKSEWVVGRTQEEAQAKAEAKFAGRKFTLEQDPDCLDTWFSSGLWPMAILGWPNTENLDFKKFFPTSMLETGWDILFFWVSRMIMLSLKMTGEVPFTEVYCHSLIRDSEGRKMSKSLGNVIDPLDIIRGIELEDLHAKLLVGNLKEEEVARATKYQKTAFPGGIPECGADAMRFTLLSYTTGGGDINFDIRVMHAYRRFCNKIWQASKYVLGKLPQDFMPKGELDTANFSVPEKWILHRMNVAVKGMNEALEAREFSRATKVAYQFFYDELCDVFIENSKGILSDGTPEEQQSVQQTLYHALDVALRLLHPIMPYITEELWQRLPRKQGDGETIMLAPYPAFESQLEFATEAEDYELGLKCAGGIRSLAADYNIKSDGRAFIKATTADSLATVSAQLAAIRTLCGKGVKEVNVLGADEELPRGCAVYVINAEITVLLQVGGSISDIDAEIKKITTKLQKTDLTIKKQQELLSKDGFEKVSEAVQESEKQKLADAQAAKENYQRTLEEFSKLKI
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MGLKITKGQLRTKDLNQSSSKSSQSSRIGVDTCIFTRMLPRINTAINLTEHLLRRSFHSLTNLQKTQVKERLHELERHGFILNKTSKQLERINSKKRRQLKKLQKTAYPKDQAFHILRKFHKINNEALADTKLGPTSQSDLKFLSLTKDKRLFYTILGVNGEQLRDSKLIANDVQKFLKRGQLEKAVFLARLAKKKGVVGMNLIMKYYIEVVQSQQSAVDIFNWRKKWGVPIDQHSITILFNGLSKQENLVSKKYGELVLKTIDSLCDKNELTEIEYNTALAALINCTDETLVFKLLNKKCPGLKKDSITYTLMIRSCTRIADEKRFMVVLNDLMNKIPDYCVDSKLLFEYCEVICSQKSPKIEKQGMGLWALCEYFQFDKTIFKKYLTQSDFPTLVPLSHWNINKPFPLNKHVVGLFMNYCLKNKEYDLAMEIFKTLEAQNNQMLDQSIYHKYMETVITTRPITCGDECLDIYERVASSAQISITRRTLILVYNAFQRQSLKAVINKDASNAEATLHKIRGFIDSVEATYSSKLNGKVYRFNSWKFLFPIVKNLNMNDKVSTVELKSILDEYLKSLLNGEFGKEFKASIEDKRFVTLEGIRLVKVLTERIKLPSLDSEEIASLKGTERKKFLARRHLLRLKQILLEDLADIEGNSRRKGDSENTSTSEERIMEDLAELILETSYDKF