lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cytokinesis by recruiting INN1 to the bud neck. Cooperates with INN1 to stimulate the synthesis of the primary septum (PS) by CHS2.
Miscellaneous:
MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Bud neck. Note=Found in association with the actin ring and the cortex at the mother-bud neck.
Sequence:
MATNLTSLKPPFKVKARYGWSGQTKGDLGFLEGDIMEVTRIAGSWFYGKLLRNKKCSGYFPHNFVILLEERLNSSTENGRQPSKIVESFEKSNKVVIPPVPSRYSDERPRPKKKLSSSMPNSPKKPVDSLTKARKAKSKEMVNEKNIYNTQSSRHHNNSAPNLPLASHSKPQVRNFEESMNNPLPPLPPLPDLDNMRKTDKRAPKKSYSANDLHMARSSREYNYYKDNQKFYDGFIPEKRYSLEEDSISSGLFSNSQYLNDSACSSENSFALMSDFSATSAGSFARHKYAQSFSDSLQRSQNANGCSTKINDSQEFGDSNASSRNGKMGDILRKIIIPKRNTNIYSSSVSSPKSPKAYPKLPDIQNLNLSATPDEARDWIAVKCHLNRARTLTKYDKHPRYMRALEENRDLILHPQDSIYNGLNTNEVKGNTKPGLVDVELAELNIEYIDKMTWKRCIRDGTMTLDSWAQTTFSARYSTVLEKLRGIYIFCTEMFALTDDNGTSDFSAEPQNLEKILYRKHCTPYELTWLFKKLANSLGITCEIVIGFLKTPSAINWEFKYNHCWLRILVNKEWRFIDVILGNVTNPIHEFVNNRKIKKAENSYFLMAPLEMIYTHIPPREFEQHIVPSIDQLSALYLPLVFPSFFKNELKLYKFSTALSFLEDSEIYECSLEIPNDVEVFASVVIPTDNEEASSAYRNMELALTQIKKQKAESGRRIALIKAVLPPNVNKGSLYIHSGVRGTQTSIANIHPLSMMVPLTHKGSNMKYEFVIKIPSESIQKIELYIVEPQSRYLFVGNEYSFEVIQSPSDGIVYSSDEGPNQNRKQPMAIKSPSGRVHELVKSDPHFPYGTWKGSIKIKEPGVWSALVIADSGIGWSVFAEWLCV
The following text describes a protein:
Function:
Acts as a co-chaperone for HSP90.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MCSRQPKVLWAQRSEKVYLTISLPDVKDVSLKCYPDGVFNFSAVGVNGDSFSVTLQLFGNISPEV
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MFRSLAKLRCFASSLGLSSHKNIKSVPLIRNIHYIPDNPSYFTQNARFNEIYLHLENILKFAPKIIAAEEDVPKKWKTLEQYQKEFSDPKTTKVGYRKITRLLNELNEIVPEYRTEAVQKALEKFIRPDIVVKTTLKSQMLDENGMSITKGKRKSSKATVKMLPGTGKFYVNGSPFDVYFQRMVHRKHAVYPLAACNRLTNYNVWATVHGGGPTGQSGAVHAAISKSLILQEPSLKQVIKDTHCVLNDKRKVERKKTGQPKARKKYTWVKR
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSFSEDQAMEEAKLRNDETEEQDPVVRTYPVFFSPGLRNNLLLNQFPLRPKNRTYSDANGEAPIDVRVKPKTGWMEVDVPIPTTKYYNEDKAMKYGNGKKPIQTQTLSGRLQKPRTNLMVGLIRDGQFHIVPLRGLTQLRPSMKHVNEYTQKLKAAAGPSNSSSGTSTPRGPIRAVQVTAKQNTEAPKVSTTHIVRATEEEEWVELDCRPERESESILKQLECPIEHQPNECAAVDEDYSFI
The following text describes a protein:
Function:
Type II nitroreductase, able to reduce 4-nitroquinoline N-oxide (4-NQO) into 4-aminoquinoline-N-oxide (4-AQO) via 4-hydroxyaminoquinoline (4-HAQO), using NADH as reductant. involved in the oxidative stress response. Plays a possible role in the metal stress response. Involved in negative regulation of fatty acid metabolism.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSPTGNYLNAITNRRTIYNLKPELPQGVGLDDVKRTVHVILKNTPTAFNSQVNRAVIIVGDTHKRIWDAVASAMPTAEAKKRPESCRDEAYGSVIFFTDEGPTEKLQRDFPALAAAFPTCAAHTTGAVQIQSWTALELLGLGANLQHYNDYVKSALPQDVPIAWTVQSQLVFGVPTALPEEKTFINNVINVYH
The following text describes a protein:
Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.
Subcellular Localization:
Cytoplasm. Melanosome.
Sequence:
AEGEGQRDLLKAVAHILGIRDLAGINLDSSLADLGLDSLMGVEVRQTLEREHDLVLSMREVRQL
The following text describes a protein:
Function:
Catalyzes the hydrolysis of ester bond in chlorophyll to yield chlorophyllide and phytol. Does not seem to be required for chlorophyll degradation during senescence.
Miscellaneous:
MISCELLANEOUS: Unlike CLH1, the expression of this protein is not dependent on the presence of a functional COI1 protein.
Subcellular Localization:
Cytoplasm, cytosol. Note=Associates with the tonoplast and endoplasmic reticulum.
Sequence:
MSSSSSRNAFEDGKYKSNLLTLDSSSRCCKITPSSRASPSPPKQLLVATPVEEGDYPVVMLLHGYLLYNSFYSQLMLHVSSHGFILIAPQLYSIAGPDTMDEIKSTAEIMDWLSVGLNHFLPAQVTPNLSKFALSGHSRGGKTAFAVALKKFGYSSNLKISTLIGIDPVDGTGKGKQTPPPVLAYLPNSFDLDKTPILVIGSGLGETARNPLFPPCAPPGVNHREFFRECQGPAWHFVAKDYGHLDMLDDDTKGIRGKSSYCLCKNGEERRPMRRFVGGLVVSFLKAYLEGDDRELVKIKDGCHEDVPVEIQEFEVIM
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.
Sequence:
MRLIRAHDGVAFEFSQQHLQAIDGLAAFFQLIAETIQIEASQIILMNPLGSQLTQNLLNSIIHQSTQDQSSSNSSDTLLYAFDRQFLSADPSEALNALACQPEHLLQLKPPPFEPNNTTHLDPEELEQLTLNYHQVGANHLRTSLLLLTHVRAQKSALEVALNNLDKCREPPQGALEAYETFAQPLVQDYGQLLEAFGPSFALAKRVKIHPALLPSNALLKSNSSQSVSNTATNATTTSTGMMKVKYMGDYVMEDKILQIRDKCLKVYEDFRNRFEMIRARSTEVNEGATKLREELNGGDCDLDDLYELEKDADDGFRRIEDLTAQIAQLARDVDPIDGLIDCFNELIVLDEDSRERIACLIERKNFWLHYLVDGLNQISRLQSIIPSIGVELQALNSDLKTRTDPFRYLARLKDFVTAYASTVVEVVRRREYARHLADYASALNNLVSKLANDERRRRGVYRTEYAGKLPFAVEGLDDKSVPTIEFEIRYIGGGGAIVPKSKDTSSKATPITGADLPPLTRADVDELVAGLQNIEDSSDNSSTDNYSPKVPAREVRLLVEKQFSRLEAMENAFAAAVEKFVMSESESCIAGQPVDAEEVSQLKARVAELEATQANLTERLRAESTAAITASRKAQQETQIHIRKTEDLKLQLLSVKEEARHEKERLTQDQQPLITELANASETIERLNERIGQLEDELKSRTKSLQDTERQVTSARATADDATRELHDLEARHRDHVSDHEIVLNRLQQSRDRCTELERGLADCQSRNQTLSSQVEDQTKLMASRASEAEELRERMEKEISELKARLEDEKQQNCNLQNKVTQQEIEIGHITQQSKLLAEAHTAAESRWKDETMTATSCLENHCRNAVQALKSYQKVHRTVKNKIINMPRPGSSQKSAVTPGASNASHPTGEATGSDSPAGVDPGSNCVREEEEELPSPLSPEFEALLQSLLQFDHESMVDLVHQKLDQLSGSIRKWMKDCKGYRERANRSQEQAQVKITFRDFAKGDLALFLPTRNPSAQVWAAFNVSFPHYFLQANETVAPIIKSREWLVARIVSLTEKMVDPKEPETNPYQLPAGTRYFLLEVEPWSVEKTSRKMAQSMIGGDSPARPKMQNQMRSTTLPSQTAPQAASSALSKRRSFVAEADNTPQPITSSARVEEGHSGASEITKPSSDPLDSTSNTQASSNVDLTQSEYTVIDRASSPGATEPSSDSPFRTSLSSSIIPTRSSLSGLTLSLKTYQKSPLGAVPASSHSPLRPLTETDNASIEGAPEFKPSESARPAFLASLSHASPSSSSSAPRKMPGAFQPPSKPRLRPVPKAHNASRSSSRAPSIASSVNLNPAVKALLMSGSPSSKGPSTVSTTFTSMEKDPTSIHPSRSPSGGSEQQVTGLAQIIKPRSGGSPGGMSMFEIARRRLSFSSPTNNYPISSIHHSAGGGPSGSAGASGSQNSVGSSSGSALIIGHPPHTPINRLEAQTIPEPSRSSPVTHNHHQHHNQQSVILASPSSVGATATGGLTGSGFFSAWRRRKESLSNPPSIPSSSSLPPPPHPPPSSSHANTLPSVQSPSSSSSVAASDLLKRLSGAVHPPNS
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MTPLSKLCAGAVTQNVLKSYFLTPSQFRSFSRTITALEKSQKSPSKQEHALQRSILEEVLVHEKAKPTTFGGKVAEKASNTFMYTAVVAGIGLIGAFIYVLAGEFFAQDSPQTIFNKALALVRDDGRCQEIFGASIAGFGEETSRGRRRHVAHHKYEKDGMQRIRVLFHVKGDRDEGIAQAEMEQRDGDWQWRFLYVENKRRPKTTHVLIDNR
The following text describes a protein:
Function:
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNDGGVPITIEFSGGLEILFGNQKKYALSVPEKDESGAPANVAFLVRYLCDNVMKDTRKELFVLDDTVRPGILVLINEADWELEGEDKYELQKVLLKGKHSLQCKNSLYDHIPSTVQACDCLHKIMICNFLGNLGQAYCGNRQK
The following text describes a protein:
Function:
Carries out a dual function: signal transduction and activation of transcription (By similarity). Required, in concert with transcription factor elt-3, for up-regulation of the vacuolar H(+)-ATPase and acceleration of lysosome maturation at molt. As part of the innate immune response to molting and injury of the adult epidermis, positively regulates the expression of epidermal antimicrobial peptides, such as nlp-29. Through positively modulating the expression of epidermal antimicrobial peptides, such as nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment. Functions cell autonomously in the epidermis, in concert with sodium-dependent transporter snf-12, probably acting at vesicular membranes, downstream of a p38 MAPK/pmk-1 pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Vesicle. Note=Translocated into the nucleus in response to phosphorylation (By similarity). Localized to vesicles, which may be a type of endosome.
Sequence:
MSSVVSDQMDIESSSAFSPAEPVVDGAFVSKHNLSAEAYQGFKECADSLLSGKIAQNEQLPFIQRTLQICENVILNFEDEKQHLMSDVLLVWAMKQQKLSIATLHTQQLHYKELDLINLQFEYFGELLQQTLSGLDYLKQYYPNVGFEEVHSKVRNLTHYFLYYSIIVSRQPPSVIVKCGEAENHRRSRFWFNTEIRILGGSAFGIDTNNENSNVNCYLITDETAKQLLNNAYLDIFESEEFCIEPNTSTFQKKDARGIKAKFDDMKVAKKVALRRDSVATKRYCLCYNIQLQTNCGIELVGKKVSLPFAVLVGPKADVEAKLFLERSFADLVRHPLSDIPTHVSCAEMADALEMKFQAIIETPQKNTDGPSVVQPRKFNMQTKQHLVMRMKPNNQGFLPLDNFMKLPVAEEFQHKKSASAEGDWKLVPFYDWFFKLAEITNKYLYSMWYDGLVYGFCSKEDAENILRCIPRSVLLVRFSDIEYGKIKISVKNRNGEIRHHWYEHADLNARSLNSELLSNHKFSDVDLIYPDIDLEVALGGRNKPRIRLPRNLAPDEIYFDNQGAAT
The following text describes a protein:
Function:
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
Subcellular Localization:
Nucleus.
Sequence:
MRLPFSLIYTQTCTVSRSCARAKLATPCPTEDLSMDDESEDAYDLFSGYDSYREYNSSELSDDISSGIGDSSFDEEENEESSSLQQSSSVTNKANEENSAEPAICEMCGIVGTRGTFFSKTKRFCNVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKASWSAKIKAFLNSQSTGQTADGTPAGQDALTLGFDWGKYITEGNFEAAPVTCFRHVPLCNQWDDVVEGIKVESLNTDAVLPSRVYWISSVVKIAGYKALLQYEGFEDDSSHNYWCNLGTVEIHPIGWCAVNSKILVPPQSILSKFTNWREYLMKKLVGSHTIPVDFHIKMTESFRCPFRQGMRVEAVDKMKMSRVRSAVVDTVIGGRMRLLYEDGEKNDDFWCHMTSPLIHPVGWAQKVGHNIKPPDLKRFEMSSHPTFRKVYCDAVPHLFKQMRVAYPEGTWFEEGMKLEAIDPLNLGNICVATVCKILLDGYLMVGLDSTPSADGSEWFCYHASSPSMFPVGFCNKYDIELTPPAGYSKEAFSWDEYLEKTGSRAAPARLFNNDCPNHGFEPGMKLEAVDLMEPRLICVATITHVARRLLRINFDGWDVEYDQWVDCESPDIYPVGWCELIGYQLQPPVEDEPKEEPKPKEVKRKKKTAFGKRRKKNPQGKKSAKKTKSATNTKNISNQQHEEPKRKYCKKAKAVKETPLTDNRENPDLSRPEDKNDLANKLGVEVLPSTSTGKSLDLLPADPEMEENCSRENICSPKSEEEEIFTVQIKEEEMEVCELEQVKSQDMKKEIKEEEEVNI
The following text describes a protein:
Function:
t-SNARE found in various SNARE complexes involved in multiple transport pathways. The composition of the t-SNARE complexes is specific for a limited number of v-SNAREs and therefore allows only the vesicles carrying the matching v-SNARE to fuse.
Subcellular Localization:
Prevacuolar compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Note=A small portion is localized in the Golgi apparatus, the majority is localized in the PVC.
Sequence:
MSSLLISYESDFKTTLEQAKASLAEAPSQPLSQRNTTLKHVEQQQDELFDLLDQMDVEVNNSIGDASERATYKAKLREWKKTIQSDIKRPLQSLVDSGDRDRLFGDLNASNIDDDQRQQLLSNHAILQKSGDRLKDASRIANETEGIGSQIMMDLRSQRETLENARQTLFQADSYVDKSIKTLKTMTRRLVANKFISYAIIAVLILLILLVLFSKFK
The following text describes a protein:
Function:
Has a complex stabilizing activity in the assembly of the mitochondrial F1-F0 complex.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MAAAVVQMSMGYRGLLAVRNRGTGPLALGVVSSQLRAFSVRKEPELDENPYYGKYRDKIQQLRRTNPSAFDARLDKRKELKQQPLGYSKQAEFAKTVEEKVGTASGKGFSKNKTLDSILNIELIKDKDADEIREIWKQYFSLRNSVYAVIPGESFELIWRRAKTCPSFLYALPRKEGYEFFVGQWSGSELHFTALINIQTAGDAAPSQLILYHYPEFQKDKGIVLMTSEIDTKFLNVQDAQCLANQVQLFYGSDGAETFGLVEKFNHKSDEFKYMAVVSFLEQSGLGKSFLNEQGHNKEDKLE
The following text describes a protein:
Function:
Required for RNA 5'- and 3'-end processing and splicing. May act on the RNA processing enzymes directly, or it may act on other regulatory molecules, which influence the activity or synthesis of these enzymes.
Subcellular Localization:
Mitochondrion.
Sequence:
MMRPSSRQPYVCWQCLSRKDSGQHIALNTRKARVASLSSLASWPISSASIAPRPTRQWDRTLRLFRERRQGLSTSTSLLGRKIPEISNEALEDFALPLEPDLQHLQDSQPKTTKRSAHLSIRQRLKQWEAENPEPFHSIPSDFALPDRPINAFTSKRSEHMLEIENIDNDNATAQVHDQDLIDTQVTPRVQAGDLVELKSEDWNIGVLAVCLGSFNGIDHFYAVTGKWFASSNFKSGFIVKNFITNSADLQPVIGALPSTVGDMSILVELQKLRAGPTREHGAGLITKMLDFQNTSRQIYQSNLERLSNPHRHLPEEEQLMTLGEIAEFLLPPKLKQSSTGFPPAALYAVYNNIRTFFDDFFHPLGQGTAGPSSIIFHVAARSDIENVARVERMVRDHYSPELLDRKSRREHDRLEPVLRQARLAIDHSRKMREWSSHGMLGPTTRVLPASTYSWSQDALTVIGVIHMWAASDVFPRSSKYQWIGAAVLRALGRYQDADVLDATVGWTFLQEIGWLMPWEIHARHSLRLPGLQVNRAGGLLPSPEEQQPAELDEDVLAPLRQDFYTSTVYCIDAPNAKEIDDGVSLEKTDKEGEYWIHVHIADPTSRIRPDSSLAKRAALMTQTSYLPGHVDKMISDEAVVAEFSLAPGRPSLTFSARLNEEGTLLDHKVTPGRIGDVVYITPQDVATAVGPVDAGIPKVSTPDVVLEVGTPPSAEDEAPTRKMTKPDELSEQNVKDLEILSRLAAAIHKVRIQKGSVPIFLPSPSADFSLVNARIEHTPSGFLACTNDPYISVKYSVSGGLHPIVDDLMGTANQIAALWCYERGIPIPFRTNLLAAQNEEALRAYTQDVIYPQLIAGKQPSLEEMRTLRNLLGGHDIAATPTFIYTMGVDIYTKATSPLRRYSDLLVHWQIQAALLEEHKRLAQGSQSLVIRKFDKYHLKPPMDDKQAARLGLPFTASHLENKVFPHLRVRERHAKTLANIDGRNELILQALVRAWRFGEGKEGQVPEKFTYTVVNVQNTCVRGRIDYFDLWAEIDLDNLAGFSLLSNMRAGDVLTVQLADVNVHMRKIVVKPVEFVQRGPERGRLFAEEQEGEGEVENGGEYIDVEHEVLQPQGR
The following text describes a protein:
Function:
May function in the process of apoptosis.
Sequence:
MADPELEAIRRQRMSELQSKHGDAGNDQSQQEAKQREDDMRNNILAQVLSQAARARLNNLALVKPEKAKAVENYLIQMARFGQLGGKLSEDGLIEILEKVSQQTEKKITVKFNRRKVMDSDEDEDY
The following text describes a protein:
Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA). TRIT1 is therefore required for selenoprotein expression.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MAAAAAARAVPVSSGFRGLPRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQKMCRHHMISFVDPLVTSYTVVDFRNRATALISLRKLSTHPWRVPSGDIFARDKIPIVVGGTNYYIESLLWKVLVTTKPQGMGTGKAVDRKVELEKEDGHELHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGVSHSEFLHRQHAEEGGGPLGGPLKFPNPCILWLHADQADERLDKRVDDMLAAGLLEELRDFHRRYNLKNVSEDSQDYQHGIFQSIGFKEFHEYLTTEGKCTPETSNQLLKKGVEALKQVTKRYARKQNRWVRNRFLSRPGPSVPPVYGLEVSDVSKWEEFVLEPALSIVQSFIQGSKPTATPVKIPYSETENKRSYHMCDLCDRIIIGDREWAAHTKSKSHLHQLKKRRKLDLDAVSALGSQSNSPDSELERKEGESSGQRDQELKASV
The following text describes a protein:
Function:
Proton-dependent uptake of di- or tri-peptides.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEDKGKTFFGQPLGLSTLFMTEMWERFSYYGMRAILLYYMWFLISTGDLHITRATAASIMAIYASMVYLSGTIGGFVADRIIGARPAVFWGGVLIMLGHIVLALPFGASALFGSIILIIIGTGFLKPNVSTLVGTLYDEHDRRRDAGFSIFVFGINLGAFIAPLIVGAAQEAAGYHVAFSLAAIGMFIGLLVYYFGGKKTLDPHYLRPTDPLAPEEVKPLLVKVSLAVAGFIAIIVVMNLVGWNSLPAYINLLTIVAIAIPVFYFAWMISSVKVTSTEHLRVVSYIPLFIAAVLFWAIEEQGSVVLATFAAERVDSSWFPVSWFQSLNPLFIMLYTPFFAWLWTAWKKNQPSSPTKFAVGLMFAGLSFLLMAIPGALYGTSGKVSPLWLVGSWALVILGEMLISPVGLSVTTKLAPKAFNSQMMSMWFLSSSVGSALNAQLVTLYNAKSEVAYFSYFGLGSVVLGIVLVFLSKRIQGLMQGVE
The following text describes a protein:
Function:
May function as a signaling molecule by regulating the trafficking of other regulators.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cytoplasm.
Sequence:
MAANKDEFSVKQISPKLGGERGARNPYGPTSLHDLVEQMEFLYVDVIRAIKNSDVDPGPCDPVVEITLGNYKSSTKDLPVGPNMDWNQVFAFDKTKGDVLSVTLKDRLTNTVINKSNFKLASEIPTRAPPDARIAPQRYPLRNTKTGFYLMMSVWFGTQVDEVYPVAWFSDASEVSTCVINTRPKVYLAPRLCYVRVTIVSGHDLISTDRNRTPSVYVTATLGQVTLKTEVSSGTNPSWNKDLIFVASEPLEGTVYIRLIDRVDDQHEERIIGKLEKKLSEMTPLKVPSSAPALFYDIEVEPAGDSRRFASRLKMKLATDQAYHVAEESIQYSSDYRPFVKGLWPCLLGKLEIGILGATGLKGSDERKQGIDSYVVAKYGNKWARTRTVVNSVTPKWNEQYSWDDYEKCTVLTLGIYDNRQIFKEDQANDVPIGKVRISLNRVESDWIYACSYPILKLGSSGLKKMGELQLAVRFVYVAQGYARYSAPFRWLLPKAHYKSPLSVYQIEEMRAEAVKINCANLARTEPALRNEVVWDMLKPKTNTRYSTCDMRKVAALAFFDLFLYWPSLIVWLAIYLVVVPCIVLVGLSGLHKFLTRKFWNKRENPRSPLIVNDLKLWKLESPNLDELEEEFDSFPSSVSDVNILRMRYDRIRMVCQRPMILLGDAASQGERLYALLTFNGDDQLASFYCWLICVLVALCWYNIPMWLWSLYPIAYWLNFTPLRNDMPCGVSNFFRRLPTNEVLF
The following text describes a protein:
Function:
May be involved in iron transport and iron homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPASISMPKILSSSSSSSSISRRKPAPAAFTRSPGCRVTPPPSLRSNTRFAGSCHTVASSGTSLAEYSGEGASAVGYQDGGLPFVNLSSSNIQRTEPILPKDESTPSLLLAALPAPQKGNGPEGHLESTPAYPAAMKALFGACLAGNATEHLWNFTWPAAVATLHQSLLPVAVLGFFTKLVVFVAGPLVGNLVSSLPLIPTYRSLTVIQTAAHFVSAAMITYAFTFPRASTAPELLLQPWFAVLVASTAVDSLSRVSLGIIAERDFVVQLAGEGRRIALAQANATLSRVDLICECMVFHAQTAGASVFAFLLSKNDPLTCIKLSCLISLSALPLHIFLGGAMNRLADGVFDHSDHRSLHAASTFDVRMIVVDAVATIRRGWSEYISQPVLPASLAYVLVCFNVALAPGALMTTFLIHHGVSPLVLGVFAGSSALMGILATFMTPNLVKELGILNAGAAGLLGQSALLGAAVLVYLTGSISRRGALFTFLGLIVVSRLGHMAYSVIGLQVVQTGSPIGKAKLIGATEIAIASLAELGMMAVAVAAKDVSRFGAVAVLSAAAVAAAAWLYCAWLANSTQHLKTLFPS
The following text describes a protein:
Function:
Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
Subcellular Localization:
Nucleus.
Sequence:
MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN
The following text describes a protein:
Function:
Catalyzes the asymmetric reduction of o-substituted aliphatic and aromatic aldehydes and ketones to an S-enantiomer. Reduces ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate.
Sequence:
MAKIDNAVLPEGSLVLVTGANGFVASHVVEQLLEHGYKVRGTARSASKLANLQKRWDAKYPGRFETAVVEDMLKQGAYDEVIKGAAGVAHIASVVSFSNKYDEVVTPAIGGTLNALRAAAATPSVKRFVLTSSTVSALIPKPNVEGIYLDEKSWNLESIDKAKTLPESDPQKSLWVYAASKTEAELAAWKFMDENKPHFTLNAVLPNYTIGTIFDPETQSGSTSGWMMSLFNGEVSPALALMPPQYYVSAVDIGLLHLGCLVLPQIERRRVYGTAGTFDWNTVLATFRKLYPSKTFPADFPDQGQDLSKFDTAPSLEILKSLGRPGWRSIEESIKDLVGSETA
The following text describes a protein:
Function:
Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution.
Subcellular Localization:
Cell membrane. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Localizes to endoplasmic reticulum-cell membrane and some endoplasmic reticulum-mitochondria contact sites.
Sequence:
MMLQLLLFCLALFIFVYWVLPTGISWYLVKRFRVKVRIGRISLPYLSLKNVHISKSGFSVQIEEVCLRSSFFTTEVTKLLSIYIRDIRINKDIHSRQDDSYDQDSYELRRTQTLAGKASEAKGVPDFRQTKVPASIITFAQFMAVHVNNISVVLMNNDFDPGWFIHATAKELHLDGSIVQNARVLLVNAALSEAQAKMLRHCSSRRQSLENLNKIRPCLGEVSFDMTLDASLFAQGPLSMDTLSLVINNAKSVIHGGLYEFLSEAKRRTSTGQPSRRSTQGLAPSKRSYDNDNYEKLAPIIPKNFNFSIKAATFSAVKENSQNDFSAKLQSFQISGKFNSKVTDEKTLLPSMLAKLGFHHLDIDTKYEKLLFVEQFTIDSVLEKDIFNLYVKLKTFQIIYNHSEIYDFVNNNFLARQRSSEAQPMQLIHKQKSLPDHLDLDTAVQSNLRANQRREGGVLEWIMQRIVVKGCAELFNVSLLMKLEDEHIAMSVSHTRFLLEQIEEKRSNLYENKFLNLLLNQRQWSMELMVETLWSNLGNSINDTNNLKKTHSPGSPFFLGVSLVKLCSYANTTKLDISVHTFRTEYSMQLAEFVVKSMECLRQYRGIKPKNMSGQSHARPNAGLTLSVQPSQSSTSLRVSVKVKDITAYFVNHHNVYSLLSFSELNLSRSQSLTTLKLEEFQMAIMRSMTASSLCLTDFSDVFATCKMIRLEHEQVEGTMGKLSIYIPGNMEATWNSNLHMHLLTLVRDMQDLKTELAIPASSVKKTTPKEGFIVELSAERSTIFEIKFSDRHSIQIFVESLFFSQKERCIIYAENVFVKIDDQHIFTVKELDLQSVPRLEVLTQERQNFPGFQLPSNKVWVTTIGSFKAIFPYDHDFYNAVNGECTSHFKWLKMVHNYKKKPFTVDSPLPCDLVIKIKEFLLEISDDPFEVKLRDNYVLLVDEYLESLKRKALFDKKIGELCSERLLLPSGTIEGLYANLVKKNSEIYIQRSKKIRESGPVRTRLLAWIMTDVNIMAMADTSIHGYNNVTRIMREIDHESPWPEEGLEFSTLWCRGVNISCTEWKFMLRDFPQPMFCVKSMRLYGNLCGAEQMGSKRAKRDVFIDVGEPFGTDVIQRSMPSLKFYHDFDCELESCSYAFGACWEPVMAQCNLSFEKISAPSKDPSPPLPFWDKLRLLLHGRLTLIAKQFTILLHASLDPYNTTEEMELTWNNCGIVLTNAKIMFKGELNVTVRTASRYDDCRLLHFPNLKLTIKLKWVCLANPNDHHAVMPCAPDKLPEYSSNQVHDSFRAFRSLNLNIWISFETKPKAGEDLEVDIPSLVLYGSTLRWFESLQLILSGVTRPTRRGPVFNNVRPRKKPLSRHYKKANLQMCLHKFQVLYWMSHALQKGFQLNGRRVSFSSEHSLTLNPIDDGLIHRPRADWSTIYMNCELNDAEIWLKSILTEKMDSSSENLASAADAFKIVRFYFLSVAKVSYGREALIPTTATSTEEDVKAQSTTPTHKLVVYDLKGAWTKSNRDVAFALFDSFMKSQKLKNNLSTEAVKSYRKEGPNSAVLKHKRSDSTITLSSTNNEVLPISNPNASMKKAPAQIHATAMLQQLIAEADHKFNVYSDDHSTQSRELQLQGLQACSAQDIIHENWSISLVNSQVLLKGCETSGYVIISAAKAEILQREHRPVWRERSLISKTTWKGLLECMQYYATVSAGDNNSLLEKEIMWLTVDNIQDKDETVINNLPDISHLVGSGRSVGGVVSETVGAFLSDNSGGAQPVQLQRIVSKCKCEFFYVSYGDAIDPNSITEVPPPPSEELQSPWEKQDDPVDAFTLMHHDLDVCTNSLQYAMILDIVNNLLLYVEPQRKQAAEKLTRMRFQLQLHSTEDQKRPIQQKQTVIRSLLMKIRSLEKDTHMISKERIEDGDSLELRQEYDHVQQMIRESKEELNTFSEDLDMMLLCYKETQLSQLSKISNVRSDESVTMVRTNEICFKRAQWRLTETDGQIGIADLVLSAFLYTKKSKSDDSVEHLLELGNIRMENLLPREIYRDVLLATEIQKDMPVDTHKRVLRIFCREKAPVGGISVKEHFEINVAPITIAITKKFYSTMLKFCFPDRDASETEVSDELDDNASTSSASTTNLQAKSSTSSSTKRSGKGKKGAKDSEFYVKIEKDDVEKMKERAEKNKLFIYIKIPEVPVRVSYKGNKEKNLEDITDYSLVIPTLEYHNVTWTWLDLLLAMKSVSRRVIFSQAIKQKLHIHQRQPILSAGERATPQEAEDKAVMLFGNRLLNENRNQKKGVFKFASSGKRSGND
The following text describes a protein:
Function:
Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.
Sequence:
MAASWSPSVTLRLVQTRLRGRCVGCGARAAALAPPAAAPGNSFRKAYTVQTPEISSSTAATKVYSKALAICHGPLDHYDFLIKAHELKDDKHQRRVIQCLQKLHEDLKGYSIDAGGLFSKLFSRSKPPRGLYVYGDVGTGKTMVMDMFYDYVEMKRKKRVHFHGFMLDVHERIHRLKKSLPKRKPGFMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKKYCNTVQLDSGIDYRKRDLPAAGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTVADCTFEELCERPLGASDYLELSKNFDTVFLRNIPQFTLAKRTQARRFITLIDNFYDFKVRVICSASTPIASLFLHQHHDSELEHSRILMDDLGLSQDSAEGLSMFTGEEEIFAFQRTLSRLTEMQTEQYWNEGDRSKK