lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MELFKRTRILSFMRYSNYGVIVSAILALLALGLLFFKGFSLGIDFAGGSLVQVRYTQNAPIKEVRDLFEKEARFKGVQVSEFGSKEEILIKFPFVETAENEDLNAIVANILKPSGDFEIRKFDTVGPRVGSELKEKGILSLILALIAIMVYVSFRYEWRFALASVIALVHDVILVASSVIVFKIDMNLEVIAALLTLIGYSINDTIIIFDRIREEMLSQKTKNATQAIDEAISSTLTRTLLTSLTVFFVVLILCVFGSKIIIGFSLPMLIGTIVGTYSSIFIAPKVALLLGFDMDKYYENETRKIKKAQEKEKMRRLYESGQV
The following text describes a protein:
Function:
Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane. Elicitins are able to load, carry, and transfer sterols between membranes.
Subcellular Localization:
Secreted.
Sequence:
TACTATQQTAAYKTLVSILSESSFSQCSKDSGYSMLTATALPTNAQYKLMCASTACNTMIKKIVALNPPDCDLTVPTSGLVLDVYTYANGFSSKCASL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MATSGAFAGGSPGRGFAPRGRAEYRLDCAASIIESQFGPIVASVFRVLAIQPCHVRRLYVLCKGTSHKNIRKAVTVLIQHGMLEYEEAEHPIFYAKIEDVLLRLHFPAYAHVIGTMYGTLAERIFEQLFLHGLMRLSRLMGTVVQLTGGQYSQTEILELFRTLVQDARVIQLHGAKDSELFTFPDECKNLDKLISQEDGATNNISADQHRYWTICHTQLLDKLQTRWGVTYIRAKISDEAAIIVEALAALRQSASPEEVATQLKRMGAKQLSREHIAEWLQVLISEGEEIVVQAGMYAYMYNHSAVATVSRTRAVEKTIEERYGIESMRIYNILCEKHYLEQDQLSKIAIAANFKATRLLINRLWKAGFVQIYEAARAQDRTTGRYMHLWTADPEAGRHLILDECIHIATNLIQRELKERQQHERILSQQEFLSQELSAEDAEYEEESVKADRKQLKKVLAGISKLHQQLLYVDRLMLQLRDYA
The following text describes a protein:
Function:
Involved in the development of the organizer region in the gastrula (Hensen node in chicken).
Subcellular Localization:
Nucleus.
Sequence:
MPASMFSIDNILAARPRCKDSVLLPPSAPVVFPSLHGDSLYGAASDYGGFYSRAVAPGSALPAVGRSRLGYNNYYYGQLHVATSPVGPSCCGAVPPLGAQQCSCVPPAGYEGAGSVLMSPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARKVHLREEKVEVWFKNRRAKWRRQKRSSSEESENAQKWNKASKTSPEKRQEDGKSDLDSDS
The following text describes a protein:
Function:
Probable transcriptional factor. Binds to the promoter of the SQUAMOSA gene.
Subcellular Localization:
Nucleus.
Sequence:
MENGGWNFFSNSIESCSSNNGGNGEQNSNSTPAWDFWQLGTTTSTSSQSQLIQWNYNNSSNIFNQDPITYTCPLNGSELIARGVNKSREYFIQREKDHNLMCLNLNLGKRHCIENYEARPHGGGEVVGFVMNKRKKHHFPGGDGAAEAVVPRCQVEGCQVALVNAKAYHRRHKVCAMHAKAPKVVVLGLEQRFCQQCSRFHLVSEFDESKRSCRRRLAGHNERRRKSSQDHYTNTRNPSQAGNYRNLAVNEGRAHSLLSPKNDSWISKGNLPARCSATINELIAESRATRLDQQLIIDKDWHRHQHYPMENLSIQLKNRSSTDHNREHVVLKSNGWGRANDAAGNLTLDFMHVRNSEFGFLSEQEQLKEEGDEEGCPEHWN
The following text describes a protein:
Function:
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver.
Subcellular Localization:
Nucleus.
Sequence:
MSSSGYPPNQGAFSTEQSRYPSHSVQYTFPSARHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRPQERRSGYEQFHPGPSPVDHDSLESKRPRLEQVSDSHFQRISAAVLPLVHTLPEGLRSSADAKKDPAFGVKHEAPSSPLSGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQQIARPSQEEKVEEKEDDKAEKTEKKEEEKKDEEEKDEKEDSKETTKEKDKTEGTAEEAEEREQATPRGRKTANSQGRRKGRVTRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKPGEDRTEPAAQPEAPAPGDGGEQAPAGDLAAAAAEPMDAGPEERGADAAPAPGPPAAEPADPEPRAPGSPGRVDGDTVQPEPREDGAPRPEPASDHDSSATCSADEDVDAEPDRQRMFPLDSKPSLLNPTGSMLVSSPIKANPLDLPQLQHRAAVIPPMVSCTPCNIPVGTPVSGYALYQRHIKAMHESALLEEQRQRQEQIDLECRGSTSPCGASKSPGREWEVLQPAPHQVIANLPEGVRLPTTRPTRPPPPLIPSSKTAVASEKPSFILGGSISQGTPGTYLPSPNQASYAPEAAKPPAGSISLGLPRPQEAAKPAAVPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGSTGAIAEGSITRGTPSGKLPVESVPSLRGSITQGTPALSQAGIPAEALVKGSISRLSVEESSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGALKQGLPVRESPGSTPLEGLICRALPRGSPHPDLKERTVPSGSIMQGTPRATADSFEDGLKYPKQIKRESPPIRAFEGAISKGKPYDGITTIKEMGRSVHEIPRQDALTQESRKTPEVVPGARPLVEGSISQGTPIKFDSSSGQSAIKHNVKSLITGPSKLPRGLPPLEVVPEGAKAVERGKYEDVKAGEPVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDEASARRTPGSYASPASRGSPMLGRAPDVTIASGKSTNHERKSTLTPTQRESIVAKSPVPGVDPAVSHSPFEPHHRAGAPGEAYRGHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQMQVSLRPDVARGLSPREQQLGLPYPATRGIIDLTNMPPAILVPHPGGTSTPPMDRITYIPGTQISFPPRPYNSASMSPGHSTHLAVAASAEREREKERERLAAAAAASSDLYLRPGSEQPSRPSSHGYVRSPSPSVRAQETVLQQRPSVFQGTNGTSVITPLDPSAQLRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKSLEAEKRPGQGLYTSSALPSGKPQPHPAVVYSEAGREKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIASDKDGRERGSQSSDSSGSLSSHRYEAPSDAIEVISPASSPAPPPERLQAYQPEVVKASPAENEATRQYEGPLHHYRPQQESPPPAAPQAEGAGQVPRTHRLITLADHICQIITQDFARNQVSAQPPQQPPTSTFQNSPSALVSTPVRPKTSNRYSPESQPPSVHHQRPGSRVSPENLVDKPRGSLRPGKSPERSHISSEPYEPVSPPQVPAAHEKQDGVLLLAPRGPEPPEQRSDSRSPGSISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGAVSSRGHTFADPASNLGLEDIIRKALMGSFDDKVEEHGGVLPQPGAVVPGGAGTSVVSSGEARREEGDPPPHAGAVCKPKLISKSSSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTLRMLSSTPPTPVACAPAATAAAPAAPHQQSRIWEREPAPLLSAQYETLSDSDD
The following text describes a protein:
Function:
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
Subcellular Localization:
Secreted.
Sequence:
MPRLFLFHLLEFCLLLNQFSRAVAAKWKDDVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETIIIMLEFIANLPPELKAALSERQPSLPELQQYVPALKDSNLSFEEFKKLIRNRQSEAADSNPSELKYLGLDTHSQKKRRPYVALFEKCCLIGCTKRSLAKYC
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Miscellaneous:
MISCELLANEOUS: Present with 11900 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MRQVWFSWIVGLFLCFFNVSSAAQYEPPATWENVDYKRTIDVSNAYISETIEITIKNIASEPATEYFTAFESGIFSKVSFFSAYFTNEATFLNSQLLANSTTAPGDDGESEIRYGIIQFPNAISPQEEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWETNRLPLSAYDTKKASFTLIGSSSFEEYHPPNDESLLGKANGNSFEFGPWEDIPRFSSNETLAIVYSHNAPLNQVVNLRRDIWLSHWASTIQFEEYYELTNKAAKLSKGFSRLELMKQIQTQNMRQTHFVTVLDMLLPEGATDHYFTDLVGLVSTSHAERDHFFIRPRFPIFGGWNYNFTVGWTNKLSDFLHVSSGSDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFDIDSPVPFTNVSIETQKSYFDLNKGHVKLTFSYRNLISQVANGQVLIKYDYPKSSFFKKPLSIACYIFTALMGVFVLKTLNMNVTN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers. Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes. Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation.
Subcellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells. Co-localizes with SAMD7 in nuclear polycomb bodies.
Sequence:
MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAVAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASGQFTVSICQ
The following text describes a protein:
Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MILMLSEMSVESQIFYSVLLFSWIVYTWEAYLASRQRKIYRTTTHVPAELGNIMDAETFEKSRLYQLDKSTFSFWSGLYSEAEGTLILLLGGIPFLWNIAEQMLYRAGFSAEYEIIHSLVFLLLATLFSAFTGLPWSLYNTFVIEERHGFNQQTLGFFFKDAVKKFLVTQCILLPVASLLLYIIKMGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGDLKESIENMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEDYSPLNKEGTEDTSGNENTELKAKVKQNLNKKQGCNNQEVLAVLGHELGHWKLGHTVKNIVISQVNSFLCFFLFAVLIGRKELFAAFGFYNTQPTLIGLMIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFARNLGKAKDLYSALIKLNKDNLGFPVSDWVFSMWHYSHPPLLERLQALKVDKQN
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. The DASH complex mediates bipolar kinetochore-microtubule attachments and facilitates the formation of additional interactions between outer kinetochore components and spindle microtubules. During chromosome movement along the microtubule, it is required both for the sliding of kinetochores along the lateral side of the microtubule and also for microtubule end-on pulling on the kinetochore. Modulates cytoplasmic microtubule dynamics by tracking the plus-end of shortening microtubules and slowing their depolymerization.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Note=Associates with the mitotic spindle and the kinetochore. Kinetochore association occurs only during mitosis. During metaphase, localizes to the plus-ends of intranuclear microtubules (INMs). In the cytoskeleton, localizes to cortical microtubules.
Sequence:
MEKYQKATQNPLENVDNVKIESENAIPSNLQAFTKSLAVLDDNVSEFRKRMNHLSATKQILDNFNESFSSFLYGLQINAFCVDYENAPLSESFLLQAKKDQFKATLMTRTGHSISDPPYDGGVISHDPNFATADETFATNDTSFIERPETYSASR
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSAPLPCGALYPEPHDSCQGPRQWSGTELGWADGGRVGGRARPHRRGTRPLAGRFSAQPAGAGRRAGAGPLDPRRAVPRAHLRDGAQFAHPEQPDEFTERVSIFAFPPRTDSPHGAVLTHSRSGTRALGTVWALVGRETVNTAQEVTYELLDQTADGFFLAADALEAQVDALEEQIFRSPRFNPVEPVFDLKHLLGQARRLTTDAREASALLGRQASTAAEQVRYRDVQDSFTRVGSRLDGLRESLSSLLDLHLALQGQRMNEVMRTLTSVSVVFLPLTFLAGVWGMKFQHMPELATRYGYAFAWLTFLLIGGLLTYWFKRRGWW
The following text describes a protein:
Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subcellular Localization:
Secreted.
Sequence:
MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVEKEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYNAPCSKDLGNA
The following text describes a protein:
Function:
A probable transcription regulator, probably involved in carbon metabolism. Binds and probably regulates expression of bidirectional hydrogenase (hoxEFUHY), probably activates its transcription. A possible regulator of redox-responsive genes. Binds 2 direct repeats of the DNA with sequence 5'-CTA-N(9)-CTA-3' in the upstream region of both its own gene (includes the transcription start site) and crhR (includes the initiation codon) in a sequence-specific manner; does not bind crhR RNA. Binds to the crhR gene, represses its transcription.
Miscellaneous:
MISCELLANEOUS: This bacterium is considerably more resistant to UV and gamma irradiation than E.coli; the E.coli-like SOS regulon model is not an appropriate model for DNA repair in this cyanobacterium.
Subcellular Localization:
Cytoplasm. Note=Localized in the innermost region of the cytoplasm, associated with DNA in an evenly distributed pattern no changes are seen when cells are grown in the dark.
Domain:
The N-terminal fragment (residues 1-88) binds hox promoter DNA.
Sequence:
MEPLTRAQKELFDWLVSYIDETQHAPSIRQMMRAMNLRSPAPIQSRLERLRNKGYVDWTDGKARTLRILHQKPKGVSVIGELKGGELVEADAEEVEKIDFAPLMKKSSVFALRVMSNDLVDDFIVEGDMLILRSVTGEEEIEDGELVAASIKGGKIAIKRYYQDGTKVVLKASNNKGPGQELKASDVEIQGILMGVWRNFQGV
The following text describes a protein:
Function:
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins. During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response. May act in an autocrine and paracrine manner. Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance. May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane.
Subcellular Localization:
[Isoform 1]: Secreted. Cell membrane. Note=Localizes to cell membrane likely through binding to heparan sulfate proteoglycans; [Isoform 2]: Cytoplasm.
Sequence:
MRLALLCGLLLAGITATQGGLLNLNKMVTHMTGKKAFFSYWPYGCHCGLGGKGQPKDATDWCCQKHDCCYAHLKIDGCKSLTDNYKYSISQGTIQCSDNGSWCERQLCACDKEVALCLKQNLDSYNKRLRYYWRPRCKGKTPAC
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MAYLLNGSKQVASSKLVNVFERDHQKGEELVHELCDQLLDPSKFGERSDTIEWLKALISGDEDFTKFCTRVKNMDSSPLCGCVWTANFVAYRCRTCAASPCMSLCAACFERGNHDGHDYNIFRSEAGGACDCGDPSVMKKSGFCSHHGPNRVPPELAPPGFLSAGKVMLDRIILAMVHILRKFSSHASLHETFIVNFTTEIEEFFAFILELVKLGSPIRTHLTQLLLNEKLYQGLMRYKGYKSIENPDTSIRNYHKNSISWFLHSVAKNTEFIYLRIPVQCVKQPIIPPDIPDRGQFKRSEEYKNYVDEITFWIVRYEFPEPVILIILNLLPDPDMKREFSKAFARHYSRIATSLANSTKVDQLSTRVVHISVQLFSNDDLAYMLAVEEHLLQIFVVSTYNIIDPSLQASNTTEKDFHQCVFFVGTDPGTNAYWPIVSDFVNVLSHPRVAMMFLADNNLVSSWVQQLTCFSGMNLIRRAISSHIEYEPSNALIAFYTEREACASPLWTMLDVLQDRESSNLSINVIRILLDALTEFFDALGFEGKPPLPYDQISFHYPLHRYLAHFLCNAIKNQAVEISDIGVDHDEAVKLMAHPLQVLACMHEIQVGMWVRNGAYISTQALAYKQYFFCSFFFDADLYLLQFCASIISPDLFIASIFERCRVTNHLTVSDHNPSSSDSSPDEDRAPKMMEAAFNILLSVLGIQIHLGLPDDEVIRSETVVLLSSQSCTYSKLSDHIPQCHESHSGLRSRHYMSLFSDCLSQLAVKKEEHYNKGEAMDQTTYILNNTAWKYYDPVFTEHRTLYKKVVQQASNHLRDNSLIPQQGITESTIWPPYIPISEPPHSYKGLTRILHCRTTHAFIYVILYKALHDHAAVTETTLAMALHVLEAALSLRNNHTEDVHGLSSPDLKRSKVEDSWHKLFHSWFESEDILINIRKTIDMVQAPLWKKMDTSHDMDVSQEQNNENSGNSQTTGQSATFVATGMTKIYVIYTKLEFIKHWLKKPKLQKNFHSFVILTQKKTLFLKGKESMLSMLIKLHDKFHGNAGSFHLDINKLFGRERTTVIPSTPTNVISNVLHVAASKSSELQMTIQVIMKSLSPSTSSSTSPMNSQDGGGPSVDYEKIKRRKQAREARIRMMQQLAEKQKQFMELGLQVLEPPFNTSPLSDDTEPPAKYECVICGTVETEMEAPSVVNAPNREQKLMGIICLAQATSVLGEILLFIATKKRNSWLRLSSYKRIVLWLTVIALIDQNTSPVHLFFKNKIFAETETADIAVGAHISTCGHHVHFSCHRDYTDSVSQHESSQISRDMPHGFQCPMCRQVSNIILPCNIRYRRTSEKNIKLILNFKKKLNFTKPDVPSDTNIVNACSTTATTISLTIQTTLHVIMMVRLNLEQHLLQLGNTLLASSTSYGSPRGANSCIQRKLPIVQRINIGLHKSSTSKTIKDLLSNLEFPTSGLNSKQELPLLLQDPISLLIKIFKLYACPVTRQPYFLSHVQLLYNLAYVQSLIQVCTQFSHDERRAWKSNVSASLGGIPFSPTDMNCLLGLVIQTLDAKTFKTDESHLFSSSGLGYLNTVFSPQSVVTNVEQSLLSYLRIAALLQSHIFSQHPIPIQSESGNEFLELVKILGDLTSLFEGKDSVSATKCLKWRSPRSVITRWCDALNNFVRTDVVISRQLINARKEWFPPKLVELPHEYSVLFQRYRQVECDKCKTIPKDPALCLVCGSYICYKSKCKRLRQDNAASRHSKTCGAGTCILLLINSSIVVVIRGSRACIWGTLYLDAHGEEDKGWKRGKPLFLKRERLELLERQWIQHSFDNSCKNWAAHRQTL
The following text describes a protein:
Function:
Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions; P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B. Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEDDPYLGGHEQMFHLESLNHTMFNPELFTQEVSLPTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKHTHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACVRGYNPEILVHPDLRYLQAEGGGDRQLTDREKEVIHQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGIWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGGGGGGGGAGSTGPGYGFPHYGFPTYGGITFHPGAAKSNAGMKHGTIDTSCKNDPEGCDASDDREAVNLSGKGTETTARKESGGGADAIAPAPPAGAEEGRSCCQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLVSDDIINMRNDLYQTPLHLAVITKQEAVVEDLLRAGADLSLLDRFGNSALHLAAKEGHDKILGILLKHKKAALLINHPNADGLNAIHIAMMSNSMPCLRLLVTAGADVNAQERKSGRTALHLAVERDNISLAGCLLLEGEAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEENGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLTEDAKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIKELVDALRQMGYTEAVEVIQAAFCTSGTAAPSPVTTTSQAPLLPLAPASTRQQIVGSTRPAVGTMTSIWSDLVTILLSFLTAPSMSQPTTPSCFKQAPLGSSTAHSPRCLLHAHLLKSQPCLLLTHEGFLIPHLNSELTVSIRSARTPGDELREDSVCDSGVETSFRRLSFTESLTSGSSLLTLNKMPHDYMQEGPIEGKI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
FQCQHCDKVCSNKRQYVKHLRYHQKSFKHKCPCCPEKFNDPSSLALHVACHVKSKGFLCGQCNKCFTSDRQLAEHMVQHSGIKPFICHFCRSGFTHSLALSRHVILHLNEQSCRCNYCKKSFKGIRELSVHILTHMDSQKCNKCDKIFSSSSELVRHFHHHMDVYQCTKCDKTFARECELKMHLIMHDSKPTLTCPKCDKTFIHSHGLNLHLRVHTGEKPFTCKHCGKAFAHSGNLTVHLRTHTGEKPYQCEYCHQAFNHSSNLKNHMRLHTGEKPYKCRACDRTFSRSSHLRNHVISHSLGKTETPMHRCEVCDKSFPELDLLTEHLKTHNDMRPHQCRFCGKAFTVPSGLAVHLRTHTGEKPYRCEYCSRAFSHSSNLKVHVRTHTGEKPYNCPTCKITFARSSDLRRHVYL
The following text describes a protein:
Function:
Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MAHVLCNRARLVSYLPGFCSLVKRVINPRAFSTAGSSGSDESHVATAPPDICSRTVWPDETMGPFGPQDQRFQLPGNIGFDCHLNGTASQKKSQAHKTLPDVLAEPLSTERHEFVMAQYVNEFQDSDAPVEQEINSAETYFESAKVECAIQTCPELLRRDFESLFPEVANSKLMILTVTQKTENDMTVWSEEVEVEREVLLEKFISGAKEICYALRAEGYWADFIDPSSGVAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATADSSIMRKLSGN
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Mitochondrion.
Sequence:
MICKYIYLAIFVFGTARIPKPSACLPGDFWKTKQEIEVQKKIDEFNQYRISALWSMVSKMEDPTLSGLDGRYIVVDQNQLYLSPISKKSEKLIFRFNLNHRGYLEVKSGFRAFIENKYSPLVFHATSWTNGFSIDVQKTNPISSYTPFVMQYLNSPWFSACRVESGNWQVFVGRMNMNEHEHCYPMSLIMKREDTWLRYYHKNNRNPIDWKLVQDCAMWPDGYPGTGRESEKGSNLEAITR