lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MSLQRRTTLGTLEASQMNSRQSTGPARVSQTAAAKNKRLTVGPGSFSTRAPLQDASNQARLSAGQPRGSMVPRRSSIFGSRPQAKNDPRPLADKGFQKACIRSLITYLTNHGYNHAISEKLLSTPTSKEFLHIVQFLFHKVDTNIKFGPKIEDEVPLVFKRLRYPFQISKSALQAVGSPHTWPALLAALAWLVDLLNYEERAIAAKERDAFDESGQRLFLEYVEQSYRLFLEGEARDADASLLDEQLAQQFEVRDAETGVDIERLEAANTALRAELDAARTQPAPLEELERKRENLISDVGKFRKLIENLQAHGDMLRKKVDEKTADLAAKRTELAAVAAENQDLTARVAAQSINAEDVARMSKEKLKVEEVLRTVTAQKDRLEKDVWQAEVQLSRHLEELEGAVRSYHAAGDRLKVLPSDAKRAGGLQFELTLHARAARPEDMLSGDLKGVIKPALAAIKDAYTSKTRAAQAEVLGLAEAQDGSEEAVSEKQDAVAQREAALRKVEAACRAEKERGEGEVRGMAAEVAATEELLQQLGSSTGADLHHADQRHQALVAELAEVRAGAAAEREAVTGQVLAALDLLMSHKAYIQETLARVHGIANAMVRDLQPEAA
The following text describes a protein:
Function:
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVKRKVDDRIKTLIDDIARHKHRGLILLVGDRAKDQVVNLHLMISRANHNAKVNVLWCMREDPDFGSTGKKQQEKRARLEVKGGLSTEASKEAFQTFLAQTNIRFCKYKETHKILGQTFGMAVLQDFEAINPNTLARTMETVKGGGLIVITFRAMRSLRQLYTIAMDVHARYRTETQRDVVPRFNERFLLSLADCDTAMCVDDDLNVLPITHKMKSYGKSCKSDAYNADLAVQGRLQHEVDLANVKETLRPSEDVGPLMQLCQTMDQAKTVLSLMQTVMEKRLDSTCVVTAGRGRGKSAALGMTIAGAIAQGYSNIMCTAPTPENVQTLFEFAIRGLKELGYRERTDFEALQGVSEEFAKCFIRINVFRGHRQTVQFVSATDTAKFAQAELCVIDEAAALPLTLVKRILGPYLVILSSTVSGYEGTGRSLSMKLVADMRRGSSSGAADARHLKELSMSDPIRYGPGDPVEKWLNKLLSLDATMENTPLTTSPHPSACELFYVNRDALFSYHPLAEELLQRIQSLLVAAHYKNQPNDLQLLSDAPGHHLFVLCADSVESSAASAPTSSTSGAARQQVPDIFCVIHACEEGQVSAQSIKSHLSHGLRPSGDLIPYTLSQYYLEEGFAKLAGLRIVRIATNPALPRAGYGSRALSLLHQYYSGSISLTAAEPKTAIATHRRGDSEADAREQAGKEHEGDDDESSAPTAMLAPRSHITNLLTPLVDRPYELVDYLGVSFGLTTELLNFWKKASYIPLYVRQAPNELTGEHSCVMVRPMGFDLRPLQREFQHRLLPLLAMPFRHLPTELALSLVGDFEAHDPHKLSAATDLSEVDHHVVRVDGVVQATTDDIAATFTAGDVQRLRLVSTTFIEGGNVLDLVPTLAKLYFGKRLFRCPDGTDGVVLSHAQAAVLLAVGLQCQTTEELAAQAAFTGVSTQQLRGLFLKALSRLSEHLVALQKIPQRAQRDGHNAGVVAGKRARSLSDGAVGDSAADEDVEDAEEVYDSHGNLKGLKVARKVKVQVCTDRTLLRDASLSVSGNASAASTGRDSLQDVFYRPTKKASKRR
The following text describes a protein:
Function:
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Miscellaneous:
MISCELLANEOUS: Very high plasma levels of CHIT1 are found in patients with Gaucher disease type 1 (GD I). Can be used as diagnostic aid and to evaluate the success of treatment that brings levels back to normal; MISCELLANEOUS: [Isoform 3]: Duplication of 24 bp in exon 10 leads to the use of a cryptic splice site. The normal splice site is still present but not used.
Subcellular Localization:
Secreted. Lysosome. Note=A small proportion is lysosomal.
Sequence:
MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
The following text describes a protein:
Function:
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
Sequence:
MEPPVKINCPTCGRRFLSDETPAMPFCSKRCQLIDLGRWMNEEIGLPHEGDPGDAPVEYLDDRDLTQPSPERQNESFHRYSE
The following text describes a protein:
Function:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
Subcellular Localization:
Lysosome.
Sequence:
MNSGQRLMCCTLTSGQSPLLQAVLQLPEPLVSGTAPGDWLLTRHHWPTGLLLWWWKKLGSGLRKMSLRISALQRLWLAGDSIHHHTVPHRIPGRKTTLEQTPVFAAWRAGIKSGGARPYEETARWKHVTLVWSRKLPIWWAASRVPGAAMTSALTQGLERIPDQVGYLVLSEGAVLASSGDLENDEQAASAISELVTTACGFRLHHGMNVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV
The following text describes a protein:
Function:
May be involved in transport vesicle docking to the plasma membrane.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MVLSVPVIALGATLGTATSILALCGVTCLCRHMHPKKGLLQRDPDPDPEKARGGVLRPAQQFNVQKSAEPVQPRALLKFPDIYGPRPAVTAPEVINYTDYTLRPTEEPAPASPQAPRDSRLKRQVTEELFILPQNGVVEDVCVMETWNPEKAASWNQAPKLQYRLDYDRQKAELFVTRLEAVTSDHDGGCDCYIQGSVANRTGSVEAQTALKKRQLHTTWEEGLVLPLAEEELPAATLTLTLRTCDRFSRHSVAGELRLGLDGASVPLGAAQWGELKTALKEPSAGTGEVLLSISYLPAANRLLVVLIKAKNLHSNQAKELLGKDVSVKVTLKHQAQKLKKKQTKRAKHKINPVWNEMIMFELPDDLLRASSVELEVLGQSAEGQSCTLGHCSLGLHASGSERSHWEEMLKNPRRQIAMWHQLHL
The following text describes a protein:
Function:
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors (such as IF-2, EF-Tu, EF-G and RF3).
Sequence:
MLTRQQKELIVKEMSEIFKKTSLILFADFLGFTVADLTELRSRLREKYGDGARFRVVKNTLLNLALKNAEYEGYEEFLKGPTAVLYVTEGDPVEAVKIIYNFYKDKKADLSRLKGGFLEGKKFTAEEVENIAKLPSKEELYAMLVGRVKAPITGLVFALSGILRNLVYVLNAIKEKKSE
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSSSRQFLSSALRQCRAAGQRTAQFSTTSPAAAIRDIPTTSFQNAPRTNTNTSSPSSNNNNNAGSSQYKSDMFNLLNSGAGSRGGRDSYNNARDVDGGQRYGSNSQKVQELLQSEVTSNNYMRMMRRRWNNGDVYAPRDLSPYEMKGRNGGWVEAADVVDELGFSPLDNYRNFSLISDYITPFGRIRHSKETGLKPVNQRKIAKMVRRAIGLGIHPSVHKHPEILKNSNGRHLLPLVVPKGQKANKTKNFDGEDEN
The following text describes a protein:
Function:
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAEKLPPEVQAQLAKFQQLKDQLDRLLLEKSTIENELREINKVLEELSVLNADATIYKIVGNLLVKSDKTSVEKELNDRKELLELRSRTYQKQESILRKQLEDLQAKINDMLSKYYPQGGQTGIKA
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSRIRIEGLLAAFPKLVGAGKQHTYVETENVRYVYQPIEALYLLLVTNKQATFLKIWIPLGFSPSLYPSWKKENVTVAQVKQYCEMESHKEKLHKLVVHLHLSVPSKGLGIQLGKTQRTHQFLESLKAEGEEKINVTTKRDGGSNFDLQGTLSLQILNQEDGLTQQKQKLLHLNWLLLHSLIPSLLTVEEKINVTLKRDGGMSNFDLQGTLSLQILNREDGLTQIKTRGNPGSLFKAHPNINEELFNSESILSLEDPNRPFPTGQAGDAAGVGLPKWRMQSTDESSSMFDLRNVVISVPLPALREAPNVRQIDGEWR
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MKCKRCTTSEGCLVSRNETFCGECFSRFVLLKFRKQMMMDEYCQQVFKVLYADKHRTAVEADEQNKRSVVLVPLSLGSSSLAMLDLLNQTLSEQRAAHNRTGFQVKVVLCGFSADMDELKRLAESLQTERLAMNSDCIKLYLLDLDRSFSTCEIHKLLLANDNHGSRKIATRENATLSSILDQFSRRSSRDDMLWFARQHLIKKFASQHQVKVIMWGHSVTRLADEVMSLVIKGRGAQIAATLDSTGMDVEYGALFKNLYPLRDVLLSEIDAYCSLSKLQRYIYNYSLQGSLFIKSQDEAAQANRAVPMAKNMTINELTRQYFDAVEKDYSNVISTIVRTASKLDYPISNGTEVIYCSICNNRVYVDPSKWLKSITVNNCHPPASDEDMSMLQMWESSSKGKETLARNQARSNIWSTAAEAPLCYGCVVTLNETKDRELNWPSREHDVSQVLAEFTLTDEE
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Also involved in protein secretion processes. It has an overlapping, although partly distinct, function compared to SpoIIIJ(MisCB).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Found uniformly distributed in both the mother cell and forespore following sporulation.
Sequence:
MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYLIEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQVDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIRSTPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAKLMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK
The following text describes a protein:
Function:
Forms the portal vertex of the capsid and plays a role in governing correct capsid geometry. This portal plays critical roles in capsid assembly, genome packaging, head completion protein attachment, and genome ejection (By similarity). The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel (By similarity). Binds to the terminase subunits to form the packaging machine (By similarity).
Subcellular Localization:
Virion. Note=Forms the portal complex located at one vertex of the capsid.
Sequence:
MGFKSWITEKLNPGQRIIRDMEPVSHRTNRKPFTTGQAYSKIEILNRTANMVIDSAAECSYTVGDKYNIVTYANGVKTKTLDTLLNVRPNPFMDISTFRRLVVTDLLFEGCAYIYWDGTSLYHVPAALMQVEADANKFIKKFIFNNQINYRVDEIIFIKDNSYVCGTNSQISGQSRVATVIDSLEKRSKMLNFKEKFLDNGTVIGLILETDEILNKKLRERKQEELQLDYNPSTGQSSVLILDGGMKAKPYSQISSFKDLDFKEDIEGFNKSICLAFGVPQVLLDGGNNANIRPNIELFYYMTIIPMLNKLTSSLTFFFGYKITPNTKEVAALTPDKEAEAKHLTSLVNNGIITGNEARSELNLEPLDDEQMNKIRIPANVAGSATGVSGQEGGRPKGSTEGD
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MGSEPQSILPKWASKPCIMGIDEAGRGPVLGPMVYGCLYCARSYEKTLSTLNFADSKTLKEEKREELFENLKANEAIGWAVDVIDPKELSAKMLKKNKINLNEISHNSATGLVTRVLNMGVLLTEVYVDTVGDSEKYRVKLSERFPSIKFIVAKKADSVYPVVSGASIVAKVTRDRALREWALDETAEGINRSFGSGYPGDPETKAWLEQHKHHIFGFPTLVRFSWGTCNSYFKDIVEVLWSVLISLSIAISAQVHTNSYGLHLYIICVYVQFKLWLYML
The following text describes a protein:
Function:
Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step.
Subcellular Localization:
Nucleus. Cytoplasm, cell cortex. Note=Localizes at eisosomes, large, immobile complexes that mark sites of endocytosis near the plasma membrane.
Domain:
The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
Sequence:
MYFDKDNSMSPRPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSNRNVGDLLLEKRTAKPMIQKALTNTDNFIEMYHNQQRKNLDDDTIKEVMINDENGKTVASTNDGRYDNDYDNNDINDQKTLDNIAGSPHMEKNRNKVKIEHDSSSQKPIAKESSKAQKNIIKKGIKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLDRRLTISQIKEHHFFKDLNFKDGSVWSKTPPEIKPYKINAKSMQAMPSGSDRKLVKKSVNTLGKSHLVTQRSASSPSVEETTHSTLYNNNTHASTESEISIKKRPTDERTAQILENARKGINNRKNQPGKRTPSGAASAALAASAALTKKTMQSYPTSSSKSSRSSSPATTSRPGTYKRTSSTESKPFAKSPPLSASVLSSKVPMPPYTPPMSPPMTPYDTYQMTPPYTTKQQDYSDTAIAAPKPCISKQNVKNSTDSPLMNKQDIQWSFYLKNINEHVLRTEKLDFVTTNYDILEKKMLKLNGSLLDPQLFGKPRHTFLSQVARSGGEVTGFRNDPTMTAYSKTEDTYYSKNIIDLQLLEDDYRIEGGDLSELLTNRSGEGYKCNQNSSPMKDDDKSESNNKGSSVFSGKIKKLFHPTSAAETLSSSDEKTKYYKRTIVMTSFGRFLVFAKRRQPNPVTNLKYELEYDINLRQQGTKIKELIIPLEMGTNHIVVIQTPYKSFLLSTDKKTTSKLFTVLKKILNSNTNKIEKELLQRNQKVIERRTSSSGRAIPKDLPTSKSPSPKPRTHSQSPSISKHNSFSESINSAKSNRSSRIFETFINAKEQNSKKHAAPVPLTSKLVNGLPKRQVTVGLGLNTGTNFKNSSAKSKRS
The following text describes a protein:
Function:
Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.
Subcellular Localization:
Nucleus.
Sequence:
MAPVAVETKVDAGLTSPSSASPNKLISSLSPTTPTDAMASTSKRTLEGEEADMETNSTLSNVPQSPQYKKRTWAPSLHLTEAPQPPQPDPRTVSEMAAQSAATALGYEGRRIKKFMQRRTVDYFGALSHLRLRQRLSTTTRPDGLRGGVYPTPHAIPNFLLPAGYDNLSTNVAKQLVHTSTNKIRCPVNVVRWMPDGRRLLTGSTSGEFTLWNGLTFNFETIMQAHDSAVRAMAWCKSGTFLISADQNGTVKYFQSNLNTLQSFTAHTDSARGLAWSPDDSKFASGGDDSLLKIWDFDSSKQIRELSGHGWDVKCLDWHASKGMLISGSKDNLVKVWDPRATPGGTCLATFHNHKNTVQACKFSPDGLRFATASRDMTVKLYDLRMMAEQTTLRGHNKEVCSLDFHPLHHDLLVSGGSEGSMLFWDLSGATNQALSGYNWGESSMIGGGGDGMDVGEGRKSGDELLYRNETAHESNVWSLEWHPFGHLLCSGSNDHMTRFWQRARLGDASTSAAPSGGGFDAINASFLGAGGADDSFIPGLGGAGSKSFIPTFTNDHMQQDGASFTAPTADDDLAIPGLGFTATANQSFPPAPTPAFTPATGANAPLQGTSSQNFGWNSRSQQQPPRPGGTYGSLY
The following text describes a protein:
Function:
Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
Sequence:
MEEPRVHNLEKLMDEGVAGIEQLQILTAFKTHVKKELVRDDSIERYFDALVRFLGQPVEDRKVQQLGHSSLCYLIKRVAMQQPGRFQGARIRDLVRVVLLQEQLQERKVWGSAVKSLEAIYLCKPQAFEAELASICAATRGSDRTKCLLFMDELIQLQQMNNRNPMEVVNRFVDLWVDVLNESDPGCSKRDIELIHDILKKYFNEAMLQQFAERVVNTRSLKHFMHTEHAAPSSAQTTSSMPSGPFDVDEELTRVMEELPPNVVNSNIGEARDYLSFEHVVKDLEHITVAFQAIKETEHNWKQRQEGIITLRKIVNGNVSRQFPDEFIQACRDLNIADCISKAALSLRTTLSSHSCHLIKEMAFKLGPLLEPLLDVLFVPLRSLLSATKKISSQTAFATAAILLCTAPYHNRLFQQCIALSRDKNVSPRTFAAVFLRIYIIRFHRRLEHSSVLVEEWLHKGLTDPQTQVREAMRVTLWYWYVPNAQSAKKVLDSMPHQMKRIIEGSIPTYLNIEYHVTASVSSNESSRRSSFGVRRYPSYAAPTQSSNLQKLAANSLGGSANVRSLSENTNRHLTTYTSLAKKSLATRHESLSPRVASSGLISSAGAANLSSENLELTEELTSNHSNTLLKKYLNTNEPAVIRKSEGEPTGDLESMYSHLSSTTLQEKQQGLLFLKNLLLLKAPLDIAKLNPLLVQLSIQSPKSFKDLLTLASFHPLIPLANLIELFAINDLPTNVLLDEFSSTDLLETVIHSFQTFFPDHHDQLFLYYVKYRSVIFNYCFGIMIDLLSGDFAFSEGSTLFREVCTRIIEACGNDFNMEKYYTLISILYRADKSQFVELLRDAPVSSKFKIANELQRCDSTFNLHSIMSRESTAESHHSDPNQQYKDGAHGGDARDANGTSNSSSDSDNEPDLESTKHLLEMTMVNPIGLGCVENVLQSHIHAYKQDQQHQDPIAEKSLSTVAEVNDEDGDGSTTTQMKLMGANTTEPSNESDKDKTSDIVAESMRGTDDPNYAKLCAIDSALIDSEDEPELNNFGGLKGLTEMTKVVSIYEKLDGDEDVEMVDDEKFKDPVEQENQETGLDEIFRDEKHDQSVKFNDIPRIIDVNKSWDRYDGESIEDTSGNTSHGTDENRPASFGTVSELVRKEMEKSPTLPLNEEDSKLLSDGINEIELKHKDDPFVRDSEDCENGTPQDRSNFLSCKQHIDILGALPDNSLTAFELGLLEILDVSDMDANRILETVNTIQNSRLRSADVSRIVGAIVSHCTDPLLHWLTDSNGLQRLWSMLTALSTADGFSDSYKCVVLYTALLIANSQLSSSHLSTDELSDAWAFALRELSKLSSYNNETYIACCELRETLIEHYSSSYLPQLLESAIKELNVAEDRVRITFLLQTLSDALDHMNTLLSLEVLGSMSSLLQQFVTNDFTEWRYHSIKLLAQIYGILVARNSPASYIRSMFSILRQPEFDLVKSYYTMDHN
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MNKLQFSIPPIDFVGQRIVNKNISTLIPIITILGFIIGFITQNVFVMLSIYGIGLAFCLLAFGLPMPYLRANYIEWQKVGTTVSRSSKKAKNE
The following text describes a protein:
Function:
As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. Also functions as a component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex.
Miscellaneous:
MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis; MISCELLANEOUS: Present with 2100 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPPKGWRKDAQGNYPTTSYIKEQENITIQDLLFPKSTIVNLAREVPQQSGKKLLINKDASLALQRGATVFVNHLLLFAREIAKSQDKKSCSVDDVLSALDHIGHSALKGPVRDKLDEYQAAVEQRKKEKLDSGEVDADGDIDMGEDKENVPVEKVKEHDEIEEQGDALQDVEESSEKKQKTESQDVETRVQNLEQT
The following text describes a protein:
Function:
Could mediate calcium influx.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFPTLSSYLHHHRPGEDILADLHTDPGLGLTAEAVAQRYEQYGRNELKFKPGKPAWLRFLLQFHQPLLYILLIAGTVKAFLGSWTNAWVIWGVTLVNAIIGYIQEAKAEGAIASLAKAVTTEATVLRDGQNLRIPSQDLVIGDIVSLASGDKVPADLRLLKVRNLQVDESALTGEAVPVEKAVELLPEETPLAERLNMAYAGSFVTFGQGTGVVVATANATEMGQISQSMEKQVSLMTPLTRKFAKFSHTLLYVIVTLAAFTFAVGWGRGGSPLEMFEAAVALAVSAIPEGLPAVVTVTLAIGVNRMAKRNAIIRKLPAVEALGSATVVCSDKTGTLTENQMTVQAVYAGGKHYEVSGGGYSPKGEFWQVMGEEVDNVLLDGLPPVLEECLLTGMLCNDSQLEHRGDDWAVVGDPTEGALLASAAKAGFSQAGLASQKPRLDSIPFESDYQYMATLHDGDGRTIYVKGSVESLLQRCESMLLDDGQMVSIDRGEIEENVEDMAQQGLRVLAFAKKTVEPHHHAIDHGDIETGLIFLGLQGMIDPPRPEAIAAVHACHDAGIEVKMITGDHISTAQAIAKRMGIAAEGDGIAFEGRQLATMGPAELAQAAEDSCVFARVAPAQKLQLVEALQEKGHIVAMTGDGVNDAPALKRADIGIAMGKGGTEVARESSDMLLTDDNFASIEAAVEEGRTVYQNLRKAIAFLLPVNGGESMTILISVLLALNLPILSLQVLWLNMINSITMTVPLAFEAKSPGIMQQAPRNPNEPLITKKLLHRILLVSLFNWILIFGMFEWVNRTYDDLALARTMAIQALVAARVIYLLSISQLGRSFLGYVTGKRQTITKASILLLGIAVAIALQIGFSQLPFMNVLFKTAPMDWQQWAICLLPMIPMVPVAILANRLDP
The following text describes a protein:
Function:
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVVVTSFKPPESPIRLEQSNVVVILDKRDLGTGTLFVSERTLSWQKDGTTGFSIEYYNVSLHAVSKDPNVCERECIYILTDPHINLFGETDQRPANDDSDVESEPDLSELILAPENPTHVQSIYEAIKICQELNPDPADVDDEDDDNLFADAEEEMFIEAESEQIGDAVVDSLAERLQNNSVDVQYSYRNGNEDEDFEDAD
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MSNPAEKKLQARSSIKWMINNDVRSMSSVDDGDESQHRPRNRDYLTSLDSVNSCFDECSSVVHSDMEDVVASRSQDEVKKHLETEIPENFLCPISYELMLDPVIVSTGQEQLQALILTPNFIMRKLIYEWCEEHNVKLEEGLTNKKLKKCRSFEDDCRRTPLPINTLVRHLSFGSVQEQKTAVTEIRQLSKSSSDHRVEIAEAGAIPQLVNLLTSKDVITQENAISCILNLSLHEQNKRLIMLSGAVSYISQVLKVGSMEGRECAAATIYSLSLADENKAVIGASDVIPDLIEILDIGSPRGQKDAAGALLNLCMYQGNKGRALKAGIVKPLLKMLSDSNGSLVDDALYIMSILCGHPDAKATMGNANSLLVLTDVLKTGSPRSKENAAAVLLAFCKGDREKLEWLTRLGAIAPLMKLGENGTGRARRKAATLLDQLGKS
The following text describes a protein:
Function:
Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes. As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites. Also plays a role in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.
Subcellular Localization:
Nucleus. Chromosome. Note=In interphase cells, diffusely distributed in nuclei before the onset of dosage compensation. Associates with chromatin after the 30-cell stage when dosage compensation is initiated. Specifically localizes to the X chromosomes of hermaphrodite (XX) embryos, but remains diffusely distributed throughout the nuclei of male (XO) embryos. dpy-26 is required for its X chromosome specific association.
Domain:
Consists of two putative central coiled-coil regions flanked by putative globular regions at the N- and C-termini.
Sequence:
MQPFKRRALTSDDDRPYADTDSMPEVDLDVDRRRQYMEQLNIFDDVSSGAYMLELEAAENGVKYDEKEDLLNVQIPPKYEDQISDPDGNRMIILNIYVENFKSYAGKHILGPFHKNLTMILGPNGSGKSNVIDALLFVFGFKAGKIRTKKLSALINSGGNYESCSVTIMFQMVKDMPVENYDKYEVLTDNCVCITRTINRENNSKYRIDDKDASQKDVQELLLRAGIDMTHNRFLILQGEVEAIALMKPTSKNPNEEGMLEYIEDIVGTNRFVAPISKLMHRVSLLEHKSSQYGASVRRHEGHLKVFEKAMVIGMAYLNTFNNLNYLRGIRVKHNLCRYAETMRDAKMSLVTRTGELEENKDIMLEAKDEVRKKETHERSLNSIVTELENKRIDWQSKKNDWHARDAKRKQGLKSCTQDLGKLMKERDEARREKFEIETAPENARISKQNMQLEWDQLKEQENVCQRTATENLIKYDQKSSADRAKHDDLEKKLSDELLQSMRAKAELDVSESELKDMTIMMEQGQKRVDELKGTLQTMMAENIRDNTELNAVTTELQDRKLKFDKAVEKLPHLKSTEQLLRSKKYELDQEVIEASNTQEVTYRHQATAKLHELKEAGLFPGFKGRLGDLASIPIKFDTAISTVFFAQLDYHVVQTSDECRIGIGFCHEYKLPRTTFVFLDHLKDTDTSGMDSTMKFPAERLFDKIHCVNPEIRREFYFLIHDILVVDSLEEATRIDKKYPGRHRYCTLNGSILNRSGALTGGGKPTTGRIRNDNNPNMSGVKKVDLSKLRAAQEKHNHALEAHLKLQLKQEEIRADNGPIIKQLEIRKRELIMSTKEQKTRIAELKSSIAAHERRMVNYREVTVEDLDEKRAQIADLKRQVEESQKSSAKIKQQIEQYKRKMDRMFMELVQKNKDSIEQAKDRMGQLEQDIARQTAIIENNPSHLEQAEKKLSELEHMCLEKRSEADALAQLEVGEDVKGIDIINAQLQTSTASIDAQRARYTEAVAARREADAAYQTTVDNYNMVKQTYDELMRIIDDLENKTMADNAELDIIESAWMQPEKLYPPGKFVRYNDPDIAAKMTDGHVVLPYECISMIEPHREAYEEHEARMLEDDVFEDTANKICKLEKDVDKFRREFDNKGVRDYAMIVSLLMNEVTSAKKFSDKLKAHREKLNELRMARFNEFSEALAFLGTTTQMLYQLITNGGDASLKFVEEGKSTDPFDGGIKFSVRPAKKSWKLIENLSGGEKTLASLCFVFAMHHYRPTPLYVMDEIDAALDLNNVSLIANYIKHSERTRNAQFIIISLRNQMFEVGNRLLGIYKIDGKTYNIMVDPIAVEIKNRPILKIFEEEIKRREKLRRAEIEPEIDLSNGLSNVVIAPKRKQRRLEMLKLSDFGLDDDSDLPEFNRFPPATRRELSVEDSDEDDEPVRRRPRRQVEEEDEEDELIEEATPSPPPIVVQRRVRRSRH
The following text describes a protein:
Function:
The FliJ protein is a flagellar protein that affects chemotactic events. Mutations in FliJ results in failure to respond to chemotactic stimuli.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MAEHGALATLKDLAEKEVEDAARLLGEMRRGCQQAEEQLKMLIDYQNEYRNNLNSDMSAGITSNRWINYQQFIQTLEKAITQHRQQLNQWTQKVDIALNSWREKKQRLQAWQTLQERQSTAALLAENRLDQKKMDEFAQRAAMRKPE