lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Alpha-ionylideneethane synthase; part of the gene cluster that mediates the biosynthesis of abscisic acid (ABA), a phytohormone that acts antagonistically toward salicylic acid (SA), jasmonic acid (JA) and ethylene (ETH) signaling, to impede plant defense responses. The first step of the pathway catalyzes the reaction from farnesyl diphosphate to alpha-ionylideneethane performed by the alpha-ionylideneethane synthase aba3 via a three-step reaction mechanism involving 2 neutral intermediates, beta-farnesene and allofarnesene. The cytochrome P450 monooxygenase aba1 might then be involved in the conversion of alpha-ionylideneethane to alpha-ionylideneacetic acid (Probable). Alpha-ionylideneacetic acid is further converted to abscisic acid in 2 steps involving the cytochrome P450 monooxygenase aba2 and the short-chain dehydrogenase/reductase aba4, via the intermediates 1'-deoxy-ABA or 1',4'-trans-diol-ABA, depending on the order of action of these 2 enzymes (Probable). Aba2 is responsible for the hydroxylation of carbon atom C-1' and aba4 might be involved in the oxidation of the C-4' carbon atom.
Sequence:
MQQVITQTLVDDRFIQISDSKKSEGLATDSTKRQSQEQPIHDKDPIKAATAAMAATPLVKEHQDTWYYPPDIANDLQSINLPAELKGEIFACAWEYTRCVIPNYTNWNRYVAFMRIIIMGIIAEFRGEMVDVTASNNLLGYDLDATLAALFEGTPGHKEMAREYKTFLLITADKASERRDGELFRRYVNALAQSPRHWFRMRDCDALARFTIASALACNDLDDIWFTEDQFEILTEIGDTLYDAVAFYKHRAEGETNSTFAYMPEDLRIKAYSECREILWALDAAWARNPKLANVINFVRFFGGPIHMMMRRYRFVEENLTIGKSETDKVVDQTRKNFKLWNRVDANKRSVLNTQRYKALIARSEELMFPGLAEFLEMGGDGICDKCKYRESYGAELSHQFGGVELCSECRLSWRKYLECFVERATKVFPELKTHFEVPV
The following text describes a protein:
Function:
GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MYFTTLLSALSLMAAAASALPHQLSSRASGAQNVVYWGQNGGGTVENNDLASYCTSTSGIDIIVLSFLYQYGNGNTIASGTIGQSCYISPSGQPQNCDALASAIKTCQSRGVKVILSLGGAVGAYSLSSQAEAETIGQNLWEAYGNTQGNGNVPRPFGSTFVNGWDFDIESYSGNEYYQYLINKLRSNFASDPSNQYYITGAPQCPIPEPNMQVIVTKAQFDYLWVQFYNNPGCSVNGPINYDQWVSNLANTPSANAKIFIGVPASPLGATGTSSGAQYYLQPSALASLVAEYKDNPAFGGVMMWSAGFSDANVNNGCTYAQEAKRILTTGSPC
The following text describes a protein:
Function:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Sequence:
MNVFNNNSSDELPQNLEDLKANSEWILGIFEAGRGPLIGPIIIAGCFWPITNHNYIVKQCSLSLNKQFYQNQVESSEIISKLKGKALQFETIEISAQKLSTKILAYTPSDVNEISLNYTLQLIKNILSKGYKIIECYINPIGFKENLNEVLKKGLGLGNNDLKFIVGMHQTIIAAQIVSLQERNTRLLQIQQDIYPSGQMGSGYPSDALTREFLSKVSIPVFIYPQDIRFAWQTVSASLKQKAINIEYLSEENWTRQTKEQFLENPSFLEYGGLHFENYYL
The following text describes a protein:
Function:
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The histidine cluster (His cluster) and Cys-125 mediate zinc-binding.
Sequence:
MESKEERALNNLIVENVNQENDEKDEKEQVANKGEPLALPLNVSEYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
Miscellaneous:
MISCELLANEOUS: FMN1 is essential for growth on rich medium; MISCELLANEOUS: Present with 830 molecules/cell in log phase SD medium.
Subcellular Localization:
Microsome. Mitochondrion inner membrane. Endoplasmic reticulum. Note=90% microsomal. 10% mitochondrial. Found to be present in the inner membrane of mitochondria. The C-terminus is located in the matrix.
Sequence:
MFTWTIYVSLLLVLAGTFLMNRNTNTDIIDTFKREVDLPIPAQPGPPFPLVTDYCDIVCGFGRGSAELGIPTANVPINQLPKGINDLDLGVYFGFAHIKTVDGQELSVETRRDGRTVVYNYGQYLSEANDDLSVLPMVLSVGKNPFYGNDFKTMELHIIHDFKNDFYGARVKFNILGHIRPELNYTTKEALIEDINIDIRTAQTVLATPPYQVFKQQL
The following text describes a protein:
Function:
Required for light-regulated photosystem II (PSII) biogenesis and grana thylakoids formation by binding to the 5' UTR of PSII subunit mRNAs (e.g. psbJ, psbN and psbA) in a light-dependent manner through a redox-based mechanism, and facilitating the association of HCF173 with target mRNAs, which encodes PSII reaction center proteins (e.g. J, N and D1), thus regulating its expression by modulating ribosome loading.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Plastid, chloroplast stroma. Note=Predominantly present at thylakoid membranes.
Sequence:
MQALSILPLKSGLLVGSRLEFELDCSCFVVSPKTTRKRLCFLEQACFGSSSSISSFIFVSSNRKVLFLCEPKRSLLGSSFGVGWATEQRELELGEEEVSTEDLSSANGGEKNNLRVDVRELAFSLRAAKTADDVDAVLKDKGELPLQVFCAMIKGFGKDKRLKPAVAVVDWLKRKKSESGGVIGPNLFIYNSLLGAMRGFGEAEKILKDMEEEGIVPNIVTYNTLMVIYMEEGEFLKALGILDLTKEKGFEPNPITYSTALLVYRRMEDGMGALEFFVELREKYAKREIGNDVGYDWEFEFVKLENFIGRICYQVMRRWLVKDDNWTTRVLKLLNAMDSAGVRPSREEHERLIWACTREEHYIVGKELYKRIRERFSEISLSVCNHLIWLMGKAKKWWAALEIYEDLLDEGPEPNNLSYELVVSHFNILLSAASKRGIWRWGVRLLNKMEDKGLKPQRRHWNAVLVACSKASETTAAIQIFKAMVDNGEKPTVISYGALLSALEKGKLYDEAFRVWNHMIKVGIEPNLYAYTTMASVLTGQQKFNLLDTLLKEMASKGIEPSVVTFNAVISGCARNGLSGVAYEWFHRMKSENVEPNEITYEMLIEALANDAKPRLAYELHVKAQNEGLKLSSKPYDAVVKSAETYGATIDLNLLGPRPDKKNRP
The following text describes a protein:
Function:
May function as an adapter protein.
Sequence:
MDRVLKRVGLSKRTQSEIKVQEQTASEEKTKIRRRRRSKSRRRSSQESKKTRGLFNIDWESVKDCKSCKSRAITRRFCSKRCDNELYRSNSFKFERFIRGSEEASTLGKKISLCDDYSLPVDNLGNRRRPNSIAVPSFTEWNIASPNEEKGSSEPSSDDEFFGHQHISVTKPQELNSPDSIAEAILPQLSAHSPNRSDIKRHPSPYYYADLYKNKVEESKTCPAKFRKEPVLQPKPSQDVLESNQLSQKIKSSHRKYRKSFSLDNPNLDKPIRARSHSRLKYKKSSSVDTQSTDSRDAPNEAVMPPNRLTSPCACLTPDDGLDDEMTRQRHVYETAFDCRISKSDDDLDQIDKVSNHPVLVQLNNARENRPGPSADSNTPQNRRKVTLLCPKPSQEDNNSVGAISQKLQEMRLPEEASVVSGALSLPLRGYTPSPPSTAPLPTKFPGKELVMNSIRSAPNLPSHPKSRLKDLHLPVKSLRGRSPNSSSGSLQIQRSAFDIEFGNSKLISEFKGRPSQPKEMKEWPLKRHKGTKDNILEFKGRRRRHKYSSTESMTASSSGGSMESIKSSTSEGNRSTTSSDSRQSSSLSSHSSDSGGTKAYCGTQNSSFLAHANKLHILSPISDKSSQEPISETSDNNRNNNSQKCSPEEAATPETMKVKRRLPQNKNLLNLGFHAGDLEIQGSDSGISIQSREGIKSRATSVDLRDLPFDMPKLRRRLRIQPSTESSVSQASSSQSVIEADRQVSSFRPKLTLNLGELDLRQRPGLGLSLVGLGMNLNNPENPPTADVIDVNLPLEKQGWFHGAITRVEAENVLRMLREGSFLVRNSESTKQDYSLSLKSARGFMHMRIQKDGNDECYILGQFSKPFHSIPEMIRHFCINRLPIRGAEHMCLLQPVIAQLL
The following text describes a protein:
Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MGACCLDPGLVSGGSGERRVGPWKETWAWGGRRGLQPVRTRGRGWEVAWLSGYRAGAPSVLRTEMRADPSNCGQQPPHAGLGLPRESASPHRWKGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWRNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGINWVCKNVSAKKK
The following text describes a protein:
Function:
May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.
Subcellular Localization:
Cell projection, cilium, flagellum.
Domain:
This protein has four EF-hand domains, three of which may be functional calcium-binding sites.
Sequence:
MGCSGSKNASNPKDGAASKGGKDGKTTADRKVAWERIRCAIPRDKDAESKSRRIELFKQFDTNGTGKLGFREVLDGCYSILKLDEFTTHLPDIVQRAFDKAKDLGNKVKGVGEEDLVEFLEFRLMLCYIYDIFELTVIFDTMDKDGSLLLELHEFKEALPKLKEWGVDITDATTVFNEIDTNGSGVVTFDEFSCWAVTKKLQVSGDPDDEENGANEGDGANAGDGVPAAEGSA
The following text describes a protein:
Function:
May be a virulence determinant.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MKKSFLLLPLSLVVLSACTSNFPAPISDADGNFSPSVIQSVNGSNVGGAWQPEIQKNSLPTTGNMVTPQQNFQPINQQPTMPTAPAQPAFQPSPKTVVSAPTVQTKTVTKTVADCVDGQHINIPRNPNTNAPDYSKISKGSYKGNTYKVNKGDTMFLIAYLAGIDVKELAALNNLSEPYNLSLGQVLKISNCDIKTVTTTVSVKQPAVTASTATPVKPAVTYTPGANGTQIGSDGTIIGPIKSEAGTSPSVPVATSSTQVTSSVNNANSTPINSNVVAPIASNVVWQWPTSGNIIQGFSSTDGGNKGIDISGSRGQAVKAAAAGRIVYAGNALRGYGNLIIIKHNDDFLSAYAHNDKILVADQQEVKAGQDIAKMGSSGTNTVKLHFEIRYKGKSVDPVRYLPRH
The following text describes a protein:
Function:
Specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) to the related monophosphates, thereby cleaning up the nucleotide pools and preventing misincorporation of 8-oxoGua into DNA and RNA. It prevents replicational errors by removing an oxidatively damaged form of guanine (8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP can be inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT may also ensure transcriptional fidelity, removing 8-oxo-GTP from the ribonucleotide triphosphate pool. However, due to the lower efficiency of RNA polymerase 8-oxo-GTP incorporation, MutT is probably not a major contributor to transcriptional fidelity. It also hydrolyzes 8-oxo-dGDP and 8-oxo-GDP to their monophosphate form. In vitro, can also use dGTP, dGDP and other various nucleoside di- and triphosphates, with much lower efficiency. Works cooperatively with MutM and MutY to prevent accumulation in the DNA of oxidized guanine residues.
Sequence:
MKKLQIAVGIIRNENNEIFITRRAADAHMANKLEFPGGKIEMGETPEQAVVRELQEEVGITPQHFSLFEKLEYEFPDRHITLWFWLVERWEGEPWGKEGQPGEWMSLVGLNADDFPPANEPVIAKLKRL
The following text describes a protein:
Function:
Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.
Subcellular Localization:
Vacuole.
Sequence:
MEVQSIAVKSFEIIKPKDSSKPYVLYTIEIGTKLKSYTVCRRYSQFERLSEDLKLELDSAVSRRWLPILPPKSTSLVGYLTGSGSLINQPSKIAERQAGLERWLKTVIVHKELKDKTSKSRALMDFLEIPSSLNSTSSSATHKSSHMDDHSANPFTSQSWLAEHNEIRASVREMYDLLSRRDELLHQSTSTSVTLTKLNQINVDGKRNLENITARLGRLTESLKLFTQPDTPKGRGTLTEGETSRRMQLISTLQDDCERLSKKILARAEIGTGIRQANQVLSSESASRDRAELLGTHSNGSNSRPTTRVLGGGGPTGSASRNLPAEETVETRQRDNRRLMDHQLNHVIAQTQDDKLKSLTQILSRQKLLGLMINQELAEQNEILDDLDRDVDSASRKLKEATKKINRLT
The following text describes a protein:
Function:
May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.
Sequence:
MENFVLYEEIGRGSRTVVYKGRRKGTINFVAILCTEKCKRPEITNWVRLTHEIKHKNIVTFHEWYETSNHLWLVVELCTGGSLETVIAQDQNLPEDVVREFGVDLVTGLHHLHRLGILFCDLSPGKILLEGPGTLKFSNFCLAKVEGESLEEFFALVAAEEGGGDSGENTLRKSMKTRVRGSLIYAAPEIVTGTEFSVTSDLWSLGCLLYEMFSGRPPFFSETMSELVEKILYEDPLPPIPKDSSFPKASSDFINLLDGLLQKDPQKRLSWEGVLQHPFWKDALRREDSDSVSEDSTFSSRNVMECSGPHDSRELLQSPKNGQAKGQKGAHRLSQSFRLENPTELRPKSIMGGQLNESIFLLSSRPTPRTSAMVELNPGEGEDPSSPQKTSPLSKMTSGHLSQGALESQMRELIYTDSDLVITPIIDNPKIMKQPAIKFDPKILHLPAYSVEKLLALKDQDWSDFLQQLCSHVDSSEKSTGALRAKLNLLCYLCVVATHKEVATRLLHSPLFQLLIQHLRIAPNWDIRSKVARVVGMLALHTAELQESVPVIEAITLLTELIRENFRSGKLKQCLLPTLGQLLYLVATQEEKTQHSRECWSVPLAAYTVLMRCLREGEERVVNHMAAKIIENVCTTFSAQAQGFTTGEIGPVLWHLFRHSTVDALRITAISALCRITRQSPTAFQNVIEKVGLNAVISSLASAICKVQQYMLTLFTAMLSCGIHLQRLIQEKDFVSTVIRLLDSPSTPIRAKAFLVLLYVLIHNRDMLLLSCQARLVMYIERDSRKTSPGKELQSGNEYLARCLDLLIQHMVQESPRILGDILNALANVSGRKHPSTVQGKQLKMCLPMMPVVLHLVMSQVFRPQVVTEEFLFSYGTILSHIKSIDLGETNIDGAIGIVASEEFIKITLSAFEAVIQYPVLLADYRATVVDYILPPLVSLVQSQNVEWRLFSLRLLSETTTLLVSQEPEDGDEEASCDSDSGLLALIRDELLPQYEHILMEPDPVPAYALKLLVAMTEHNPAFTRLVAESKLVPLIFEVILEHQESILGNTMQSVIALLNNLVAYKDSNMQLLYEQGLVGHVCNMFTETATLCLDRDNKTNTEPAATLLASLLDILLGMLTYTSRIVRQALQAQKSGSRGDTQAAEDLLLLSKPLTDLISLLIPLLPSEDPEISEVSSKCLSILVQLYGGENPESLSPENLVTFADLLMAKEDPKDQKLLLRILKRMVTSNEKLLESLRNTGSLLQALERLAPAHSSPVDTVVASLALDLLQAVGH
The following text describes a protein:
Function:
Acts as a GTPase-activating protein (GAP) for SAR1. Contrary to its SEC23 homolog, NEL1 does not associate with SEC24 and its homologs, nor does it associate with the COPII components, suggesting that it is unlikely that NEL1 functions as a structural component of the vesicle coat machinery. May function as a signaling molecule.
Miscellaneous:
MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Is diffusely localized throughout the cytosol, and does not accumulate at ER exit sites (ERES).
Sequence:
MCSPTNFLYEPFSSDAVTQNYDQNLKCTKCGAYYSMACSLREQNVWTCLFCNQSNSNAELPLVPSNTYTLTSAKKEILSRRTIMIIDAICDPHELNYLVSILCNNYITRQQEPLSIITIQQSGHVILHNAVNHRRDAVFSINEFMTKYNLDKLNASYFEKKISEINQESYWFDKSTQGSLRKLLREICKIANKVNISSKRDKRCTGLALFVSSVLASQCSLSAYCHIVSFLNGPCTKGGGKVMSRERGESMRQNHHFESKSSQLQLSKSPTKFYKKMLEKFANQSLIYEFFIASLDQIGILEMSPLITSSMAVSQFDSFNDERFAMSFQKYLNLRDHNAIYNCHSKIMTAKNAIVVKDFPKYSLNPKNLSLPLEISLGHNSAEAPIQFQTTFENQTEKYIRIETLLLPKANRSFGAQNEIVFSMKKIASRIIDSFAYSSKHTKELMKQLFLLPNQIRGKDVDMVNLIQWCYHIYRSPILSVRNTSPDERYLFLHRIINASKDTCLSLCKPFIWSYSDLKHDWIVLDVPLTRAQILQDDKTTICVDGGSYLVLRRGKLLEKEGRELCCKLLNDLQRFPQPLYVETKTGGSQDRFLKSKIIPLDITDKETLGTEDMTFNEYFNLFTDLSGSK
The following text describes a protein:
Function:
Transcription factor involved in abscisic acid (ABA) signaling pathway. Transcription factor activity is fully activated by ABA. Acts as a positive regulator of the expression of abiotic stress-responsive genes through an ABA-dependent signaling pathway. Acts as a positive regulator of ABA signaling and drought stress tolerance. Plays an important role in ABA and auxin responses. Involved in ABA signaling and stress responses by directly binding to the ABA-responsive element (ABRE)-containing genes, especially WRKY family genes. Modulates response to auxin. Suppresses auxin signaling by targeting ABRE-containing genes related to auxin metabolism or signaling.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing BZIP46 display increased sensitivity to abscisic acid (ABA).
Subcellular Localization:
Nucleus.
Sequence:
MELPADGSALARQGSIYSLTFDEFQSALGSAEKDFGSMNMDELLRNIWTAEESQAIAPAAAAASAAAVVGDAQQQQQPIQRQGSLTLPRTLSQKTVDEVWRDIMGLGGSDDEDPAAAAAAAAPAQRQPTLGEMTLEEFLVRAGVVREDMGQTIVLPPQAQALFPGSNVVAPAMQLANGMLPGVVGVAPGAAAAMTVAAPATPVVLNGLGKVEGGDLSSLSPVPYPFDTALRVRKGPTVEKVVERRQRRMIKNRESAARSRARKQAYIMELEAEVAKLKEQKAELQKKQVEMIQKQNDEVMERITQQLGPKAKRFCLRRTLTGPC
The following text describes a protein:
Function:
Transcription activator of genes involved in the regulation of meristematic competence, such as CUC2. Positively regulates axillary meristems (AMs) formation and development, especially at early phases of vegetative growth, probably by specifying a stem cell niche for AM formation. Modulates the negative regulation mediated by gibberellic acid on the timing of developmental phase transitions.
Subcellular Localization:
Nucleus.
Sequence:
MGRAPCCDKTKVKRGPWSPEEDSKLRDYIEKYGNGGNWISFPLKAGLRRCGKSCRLRWLNYLRPNIKHGDFSEEEDRIIFSLFAAIGSRWSIIAAHLPGRTDNDIKNYWNTKLRKKLLSSSSDSSSSAMASPYLNPISQDVKRPTSPTTIPSSSYNPYAENPNQYPTKSLISSINGFEAGDKQIISYINPNYPQDLYLSDSNNNTSNANGFLLNHNMCDQYKNHTSFSSDVNGIRSEIMMKQEEIMMMMMIDHHIDQRTKGYNGEFTQGYYNYYNGHGDLKQMISGTGTNSNINMGGSGSSSSSISNLAENKSSGSLLLEYKCLPYFYS
The following text describes a protein:
Function:
RNA-binding protein that associates with the RNA exosome complex.
Subcellular Localization:
Nucleus. Note=Colocalizes with the nuclear exosome and ribosomes.
Sequence:
MSSKLLSMKFMQRARGIDPKQAEEELSKNIVTDEHWSLAGKVDFLPQKMTRNVEYESGYGGLIEENDLESHSNEPNLVQGRASFGLFNKELGEENVDEKDVSKNEEVDVNGTKITDTSELTERERRKQELVSKKAEASRKMEVKAPAKESKKRKVNELSQDVISLHSPKESNARKTKKNKNKKKKKRN
The following text describes a protein:
Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
Subcellular Localization:
Nucleus.
Sequence:
MDTLQEEEEGAVAAGGEGSDDQGGQEAEDVGTAGAKKVKNVVRKPQPKLNLEDLDTILGVLDHWAHRTFPRFHSEFFYQRLESLGKKRQLQVYLRRLRLGLEDGVPLVGTVQDADDNALEEVREDPFSSLLDGPRDSAADDGETERPPSPQLPVHTSTTKPIQARPVGAKTVRTTTASARAKPIQARPVGARTVRTTTASARLILPCLVEPTRVNPDLGKLQRVKLASGEPVGIVPTPRKPTQAWHIWVESAQTKAVPVMLVRVDLAQFRPIPIEPLETVQTGLVQA
The following text describes a protein:
Function:
Tumor formation by A.tumefaciens involves the transfer and integration of a defined segment (T-DNA) of Ti plasmid DNA into the plant nuclear genome. The virD operon encodes a site-specific endonuclease that cleaves at a unique site within both 24 bp direct repeats flanking the T-DNA.
Sequence:
MSQGSRPTSSDIAVNQRECVKVEGFKVVSTRLRSAEYESFSHQARLLGLSDSMAIRVAVRRIGGFLEIDAETRHRMEAILQSIGTLSSNIAALLSAYAENPTMDLEALRAERIAFGKSFADLDGLLRSILSVSRRRIDGCSLLKDAL
The following text describes a protein:
Function:
Proton-selective ion channel. Biphasically modulated by acid and alkali, mediating proton influx and efflux in response to extracellular acid and base stimulation, respectively. Sour taste receptor, which carries inward currents in response to extracellular acidification (By similarity). Sensor for ammonium chloride (NH(4)Cl) in taste receptor cells. NH(4)Cl acts by increasing the intracellular pH, thereby generating a driving force for proton entry through OTOP1 channel. Might also participate in alkaline sensation. Plays a role in the regulation of Ca(2+) flux in response to purigenic (ATP, ADP and UDP) stimuli, leading to increase in cytosolic Ca(2+) due to influx of extracellular calcium. May play this role by inhibiting P2Y purinoceptor-mediated Ca(2+) release in a Ca(2+)-dependent manner and promote an influx of Ca(2+) in response to ATP. Through this mechanism and possibly others, plays a role in the formation and function of calcium carbonate-based structures in the vestibular system of the inner ear, called otoconia, that sense gravity and linear acceleration. In obesity, may attenuate adipose tissue inflammation, through the negative regulation of IFNG signaling, hence may play an adaptive role in the maintainance of metabolic homeostasis. Following alkali activation, may also be permeable Na(+), K(+), Cs(+) and Li(+) (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, microvillus. Note=Found in the gelatinous membrane overlying the inner ear macular epithelium. Also detected in the apical microvilli in inner ear supporting cells.
Domain:
Residues involved in the gating by extracellular Zn (2+) and pH are located in the extracellular loops between transmembrane domain 5-6 and transmembrane domain 11-12.
Sequence:
MLEGLGSPASPRAAASASVAGSSGPAACSPPSSSAPRSPESPAPRRGGVRASVPQKLAEMLSSQYGLIVFVAGLLLLLAWAVHAAGVSKSDLLCFLTALMLLQLLWMLWYVGRSSAHRRLFRLKDTHAGAGWLRGSITLFAVITVILGCLKIGYFIGFSECLSATEGVFPVTHSVHTLLQVYFLWGHAKDIIQSFKTLERFGVIHSVFTNLLLWANGVLNESKHQLNEHKERLITLGFGNITTVLDDHTPQCNCTPPTLCTAISHGIYYLYPFNIEYQILASTMLYVLWKNIGRKVDSHQHQKMQFKSDGVMVGAVLGLTVLAATIAVVVVYLIHIGRSKTKSESALIMFYLYAITLLMLMGAAGLAGIRIYRIDEKSLDESKNPARKLDSDLLVGTASGSWLISWGSILAILCAEGHPRYTWYNLPYSILAIVEKYIQNLFIFESIHREPEKLSEDIQTLRVVTVCNGNTMPLASSCPKSGGVARDVAPQGKDMPPAANGNVCMRESHDKEEEKQEESSWGGSPSPVRLPRFLQGNAKRKVLRNIAAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMHAAASLFEVYCKI
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAEEIQKERREDGTSMWLYKGLPPDVGEDETLVQSTSNPQKFISSFMKRHTPENRSSEVQRILKHQDVIMDGIKKKKKKQKGKKGGVKEGRGGIPQGRGKKRLSYREKRKLKLFDIPEDQQRYELFEPLHQLWLDYMREAVLAHNPEMKNKNMLESRLLKCELHGCILTVTRSKCPAYVGISGILLQETRNTFKVITKENKMKTIPKSQCWFMFTIDQYAITIYGQHFCQRSSMRAAKKFKAKTTIEL
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MVTSASKFFLSPAKAAAIMFMLLLLNPACQAQLSSKFYDKTCPKALTTIRTSIKTAIARERRMAASLIRLHFHDCFVQGCDASILLDETSSIQSEKSALPNKDSARGYEVIDTAKSAVEKICPGVVSCADILAVAARDASAYVGGPSWTTYISLPKQRPKCSGHGCFIRFPYSRTAQCFTFRERIYSNGTKIEAGFASTRRRRCPAIGGDANLAALDLVTPNSFDNNYFKNLIQKKGLLQSDQVLFSGGSTDSIVLEHSKNRETFNSDFATAMVKMGNLINPSRGEIRRICSAVNK
The following text describes a protein:
Function:
May be involved in the CpXpG methylation and in gene silencing.
Subcellular Localization:
Nucleus.
Sequence:
MLSPAKCESEEAQAPLDLHSSSRSEPECLSLVLWCPNPEEAAPSSTRELIKLPDNGEMSLRRSTTLNCNSPEENGGEGRVSQRKSSRGKSQPLLMLTNGCQLRRSPRFRALHANFDNVCSVPVTKGGVSQRKFSRGKSQPLLTLTNGCQLRRSPRFRAVDGNFDSVCSVPVTGKFGSRKRKSNSALDKKESSDSEGLTFKDIAVIAKSLEMEIISECQYKNNVAEGRSRLQDPAKRKVDSDTLLYSSINSSKQSLGSNKRMRRSQRFMKGTENEGEENLGKSKGKGMSLASCSFRRSTRLSGTVETGNTETLNRRKDCGPALCGAEQVRGTERLVQISKKDHCCEAMKKCEGDGLVSSKQELLVFPSGCIKKTVNGCRDRTLGKPRSSGLNTDDIHTSSLKISKNDTSNGLTMTTALVEQDAMESLLQGKTSACGAADKGKTREMHVNSTVIYLSDSDEPSSIEYLNGDNLTQVESGSALSSGGNEGIVSLDLNNPTKSTKRKGKRVTRTAVQEQNKRSICFFIGEPLSCEEAQERWRWRYELKERKSKSRGQQSEDDEDKIVANVECHYSQAKVDGHTFSLGDFAYIKGEEEETHVGQIVEFFKTTDGESYFRVQWFYRATDTIMERQATNHDKRRLFYSTVMNDNPVDCLISKVTVLQVSPRVGLKPNSIKSDYYFDMEYCVEYSTFQTLRNPKTSENKLECCADVVPTESTESILKKKSFSGELPVLDLYSGCGGMSTGLSLGAKISGVDVVTKWAVDQNTAACKSLKLNHPNTQVRNDAAGDFLQLLKEWDKLCKRYVFNNDQRTDTLRSVNSTKETSGSSSSSDDDSDSEEYEVEKLVDICFGDHDKTGKNGLKFKVHWKGYRSDEDTWELAEELSNCQDAIREFVTSGFKSKILPLPGRVGVICGGPPCQGISGYNRHRNVDSPLNDERNQQIIVFMDIVEYLKPSYVLMENVVDILRMDKGSLGRYALSRLVNMRYQARLGIMTAGCYGLSQFRSRVFMWGAVPNKNLPPFPLPTHDVIVRYGLPLEFERNVVAYAEGQPRKLEKALVLKDAISDLPHVSNDEDREKLPYESLPKTDFQRYIRSTKRDLTGSAIDNCNKRTMLLHDHRPFHINEDDYARVCQIPKRKGANFRDLPGLIVRNNTVCRDPSMEPVILPSGKPLVPGYVFTFQQGKSKRPFARLWWDETVPTVLTVPTCHSQALLHPEQDRVLTIRESARLQGFPDYFQFCGTIKERYCQIGNAVAVSVSRALGYSLGMAFRGLARDEHLIKLPQNFSHSTYPQLQETIPH
The following text describes a protein:
Function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
Sequence:
MIRPDVVGPEQPQSPYPVQLSGIVSKGFGRGGKQLGIPTANLPENVAQTAGELLETGIYYGWACVGHDASSAVLPMVMSFGWNPFYKNEKRSAEVHIIHEFPKDFYGADLRVIVAGYIRPEQNYTSLGNDVCKLDALIQDINTDIKVAIQSLQRPAYLALQSHPLFTDST