lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSRVARQKTAISLLRQSNGRRLQPSVAGLRFHGNASKPSLLASASVTTPQEQTHRPSFQSNRTLATAADQSAVDQGSYASFDDSHYAPENFYDPSQQWSKLFPSLPAKELDPSSLIIVGESLQTKPKVSRKVRGIGGDEDEMLANLDVSLKVGRFDRAATLINRLGQHYPVGSSEYLAIHNRYLEKMVSHMIVTRQHNMVLPMQRWFELDMPNGGVKADATTYAIMIRMALRMLHGSKRDRAVRRYWQFAKKDNIEEEVLAVPVLSELELGELSEICSSDLQRVAIGSIGSEPAPAVAVSSQTDNLAEVRPVEQKGLGLSSLKQSLSLFLSESSPSVPADPEQKLAFDELKQRQLEADSIRSAMNRWRQEFDNRQKLGLDATAGGKKLGAIMTEWHSSLVARIKEELELVAEAEANPIRTLEQKERCEYGVYLRCLDTDTLAALTILAVMSTFSRGGMEKGLKVSAVVSTIGKDLQDELIAEAALKNEAGTDSRRLKALKELLAGRKKKGGRAKWHALVQKMQKEDATIMWSPRVTAKIGAVLMSLLFEVGKAPVTMEDPETKKKTVTMQPAFQHAYQITWGRRTGYLHLHPAIVQIVAKEPTADLLGRHLPMVCKPRPWKGMKDGGFLLYQSDIVRTTPGESLQPTYIKTALENNGLEDIRRGLDNLGSTGWTINREVLNVMLEAWNSGEAVANLAPLEPDLPLPPKPAPEAGYHAEKEWDTLVREIENRRSGLHSMRCFQNFQMELARAYRNVTFYLPHNMDFRGRAYPLPPYLNQMGADNSRGLLLFSEAKPLGASGLRWLKIQIANLSGFDKASMSEREQFTMDHLDDVLDSADKGLHGRRWWLKAEDPWQCLAACCELRNALRHPDPTQYPSRLPIHQDGSCNGLQHYAALGGDSVGAQQVNLEPSDRPSDVYTGVAEFVKKEVAREAAQGHPIAKILDGRITRKIVKQTVMTNVYGVTFMGAMRQVRKQLIDHYPDLSYEDKKNGSLYIARKIFEALGTMFNGAHEIQHWLGDCASRITTSLSPEQIEQIAKEALTPSSGRSAAKLKDPSEKFRSTVIWTTPLGLPVVQPYRVRKARRITTTLQDLSIVDTNSEDVVSKRKQLQAFPPNFIHSLDATHMIMSANACNQAGLTFSAVHDSFWTHACDVDTMNQILREAFVRMHSDDIIRRLASEFQVRYGQNLFLAKVDAGTKIGRAIRDFRKGGKKKSGKVQELLDEYKRQQLLRSDDPELQAQGRAMVTAGSVFEQLGGTDKDLAIASSLGESAVGHIPEDLAAAERKTPGLGIDTSDPAIESLFSDFQDLEPRGGEADKATGAELEDEMVAEDGAGKKKKKVRQHVWLWLPLRFRDVPAKGAWDLTRIRDSQYFFS
The following text describes a protein:
Function:
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSAAPAPSTHAAKSIRKNGKNWHDNKKPFRPNGGLTSYTKRAAARKEQEAIKEYEKELREEREAERQAHIQRIKERRAAKEEKERYEKMAEKMHRKRVERLKKREKRNKLLNS
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Subcellular Localization:
Nucleus.
Sequence:
MKMRSYSDKNVMPETEIGSTGSPFSWLYHYNPTSKPGFSSLQRTGIHHEPGLIVSPIRTIAATTESGNNNDLGTKTTKVGKQKSSVKGSNQIAPKVLGPKQPMKKPSLPKKGKGASIPETKREKKNPNINLDGTKFDFSGVPSPICSCTGVARVCYKWGASGWQSSCCTINISECPLPMSPTRPGARVAGRKMSNGAYFKLLLRLAAEGYDLSHPVDLKDHWARHGTNKFVTIK
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MRIVQPLWIPKDTLNAVSHAGELLAVAGDAGVDIWSTRFVDDAQTPTTTNVETKERYLITRMTYGAAVYCVRFSPDSKWLAVATGTSTYIYKNNQWTEPVQILPYPALDIAWNRLSRVLAIGMKTIHVFLLLQEEDPDVAGTDAKPPVNVPQNAAEKPAVEPSRELKEQHSVASVVAVSEGPHSDRPFVHVKEITGHQSFVCGLTFDPIGLYLASQSHDRTLKIWKLSTFGLEKSIAKPFEDMTLASRFLRLSWSPDGAHIASVNAVNGLSNVIAIVQRDSWSFDINLVGHQGAIECAAFNPHLFNCPFKSPSLPAVRTMARFAYGRPREPTQQLCFTDYPYSNVFVFVFEEDEFGPRMQLPEMPEQPFPVPPPVVHSAEKETVPPVTSKPLPVTAKTTASLDPSTELPSPHVDTSHLPLKRLKRDTNQTHSQPVHATVAETNAQIRLARPCVRPHWTLPAGINGIYLALHNYEKFSCFEVRTDDGNSSFALASSSWKSYLPSSIVLARASKKCISLACEDGVVHIYSPNGRRLLPPLTLASVACWLECENEFVLCITSTGLLYVWNVDTRRAVHPPVALHPLFHVNAHVGEVKRAASIMHVFVTASGNAVVVLSDGNCFSYDASMQTWIRVSEGWWMIGSQYWDTPFATDALSFLERCTDDEIMKQGRGRFLQRVVKASMLRQGYENYETVVSVRHLESRMASAASNAFAKSYHDALILYAKRIAEEGMKEKLEELCRELMGPPGLRRADEVAVQLGTRVWEPTVASLRKRDLLREVLMAVGRQREVQRITSQYVELLDNLEKS
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
KNVLNFSKKCDKLKVLIHVSTAYVSGEKEGLILESPLKMGETLNGTSGLDVDFEKKLVNDTLKKLKADNCSDDFIKSSMKDLGIQRARTFGWPNTYVFTKAMGEMLLGQLKDKIAVVIIRPSIVTSTYKQPFSGWAEGVRTIDSIAVGYGKGRLTCFLGDPKTVIDAVPADMVVNAMIAAIVAHANDDQGNITVYHVGSSVSNPFELGWLQDYGHRYFSKNPWINKEGRPVIVGKIKILNSMDAFHTYLAIHYLLPLKGLQLVNMACCQYFQGIYVDLCRKIKYVMRLVELYRPYLFFKGYYDDMNLEKLRRAVRESGVERDFYFDPKIIDWDDYFMNTHIPGAVKYVFK
The following text describes a protein:
Function:
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
Subcellular Localization:
Nucleus. Chromosome, centromere.
Sequence:
MEQSMSSEQAERVAGRVEQLGGFQNNESINQRALLLLQRNRQRRQLLQRQEDRTRYIPDDAKRRVVERVAEPAAAESRADGAREEERAARPARPRETRRIAKKPQRYRPSDVALQEIRRYQRSTELLISRMPFARLVKEVTDQFTTVDQQMRWQSMAILALQEASEAYIVGLLEHTNLLALHAKRVTVMRKDMQLARRIRGQFI
The following text describes a protein:
Function:
Necessary for the efficient intracellular multiplication of tobamoviruses.
Sequence:
MATASENSRGISGGDRTAKAVVADQISQAVNSTANLLHLMRQSSSSQAQLAKLPKNLLAKASLTKATGQALAQLPQVISSLDAHIESGLHSGVHLNTVTQLLENMESTQLRALRQSNISPVV
The following text describes a protein:
Function:
Could be part of a sulfur-relay system.
Subcellular Localization:
Cytoplasm.
Sequence:
MKPLTYTLVVNGPQYGTQSARNAYLFAKALIEKGHILKSVFFYQDGVLNGSSTHVPANDEFNLLQGWQSLAQSHQVQLETCVAAALRRGVVSEQEASQHGLASHNLAAHFTQAGLGSLAQALLEQDRVVQF
The following text describes a protein:
Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Cytoplasm.
Sequence:
MMRKLKTLPPTLRDKNRYIAFEIISDGDFTKDEVKELIWKSSLEVLGETGTAIVKPWLIKFDPNTKTGIVRCDREYVEYLRFALMLVSEFNGKRLIIRTLGVSGTIKRLKRKFLAKYGWK
The following text describes a protein:
Function:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Subcellular Localization:
Golgi apparatus, trans-Golgi network.
Sequence:
MAGTEEMDEKAKRMRALLSSFYGEDAGSQPATPVRRDTLQGINLPDFDSDRYMQSLLRRTPLEGLLQKHVEMAAEIKNLDSDMQMLVYENYNKFISATDTIRRMKENVAGIESNMDQLLETVTAVRAKSDGINASLCARRERIEELNGTRSLLRKVQFIFDLPKRLRVCLKSQEYGKAVKYYMGALPILKTYGKTSFAACREESEEIIDSISQKLQVQVADDKLSLETRAEAVRLLQQLEFPVEKMVENYFATHWPRLMAALQVVEPETPGLVGRLQGWLWFGTKKVEVEKLADESDGASPQKSMEVLNKDFIGDFTHTAVTYRALFPDEENRLTEAALKLFHEYFANVQKSLKPKTGKPSIVELTAALNILSQDTGNMQKLVPEAGLPEMTEKAVETAIHQHVVAMFSDLYARIIGSLVIDEPTPSKEGEETKNLKPLRAALDNAKRVILFDSVEILRDLRDLLEKCGDLLEGWKDAYIDLVQASFQELFTNLNDHFLHLCSNSQDQVNAPKFQTASQGLVLMLALLSVYIQQTAVPKITEVVGASFVGGGAMGFEARPAFVPSEICRLFYSSGEKFLHEYIDTQARKVSTLIRKSVETPNWLKYKEPRDVRMFADLLLQEVNRVQLEVEQVLDQGSTRSHRRTDSSGSAGSSRSNAASMRDSTGMRDSGSHRTSITARARSRLLERDVAKLFKQKIELFTKVEFTQSSVMSTIIKMCLKTFQECVRLQTFNRSGYNQIQVDALYLRDNLREKVFDNETVVDSLLDEVCQAAAERCIDPIPMEAAILDRLIEAKRAKGS
The following text describes a protein:
Function:
Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MYFLILFSSNAELGEVLRTMRSVEDRFNKRFHYPWTFYGMDEFTEYFMSTTSTIASGHCEYGTKGITYTNHLQFILTISYLVHWDLSQVKPLVENNRLYQQRADALAQENLSYVYSPLFHSFQDWVVRSLLYHPQLEYDYVWRIEPGLKLVCEEKKDIFSTFKDSDIVFTNHVCERKHSGIYAMEEAIEEYKILNTQGDFSNIWVYSNNYTYCKYWPFNEILSLKQIRHNQTYTNLINYLLGSGGTYYHRWTESDILSAAFGVLRARANHMESVGFFLNDDVHYCPETIPYTGRCACL
The following text describes a protein:
Function:
tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development.
Miscellaneous:
MISCELLANEOUS: The tgrB1 gene is highly polymorphic.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MKVIYIYLLLLLVCKFLFVKSSCSLKVGKIECTKELETFLLYNETVVNVKMDTNGVKYYFNALEFPYKNLLCDLNIDIKFTPEIPSFPNIPTTGGDFGFTFNFPCDYRRRVKRIEIERTILSLSFDTSKNQFVTYLNPGCGPFNISSSGIQILSTTYETGAIPNVPILDDDKGILTIQGSNLYNTSIKIYSNNILKDTNPSGALDASHSSVTFSAEEFLTPNNWTIEVSICGSFYKSYSFPYFPKLDKMEGVLNDNGGNMVFTGKHLRPKHNVTGTFGNKTIECLTSNSSKSITCTIPSRKNYGFLGYDIPVTITIDGEYKSNTIKISYDLPLIQSVSQRGNSQIFDVTGVYFSGVKNMTVITGKNMKTDIIQKKTATLEEPGFFIESNYTIFIFLPNNTQPGFMNLVVGDGGSETFTSPRYNFKITPTITAGQTFNSTTSGNDLEIKGIFMRTVDSDGRDVPLTVNSGSGGLVCNPLKDGDGLLFTCVLGPGFGSSHTMNVYYNLIPIGSFTVSYNPPYLGTSEQEKDGTIKMNGKDLGESVKDSIMTVVYSDGNTVNGTVIKSSHTSLIFRYPIGNRNTASYIFQLGDQKSNKAGPFTLKPIIENTDPAVPCGGGVVTINGHYFFNYTKDTTTITIGKVPCNISSISETTIECVIVPNLRSLSPYYTSGTKPLVISSSNPGTEKVYQLTPAGLNYKFAPPTITNTSAIDQTALITIYGTSFGDANLEILINDKPCTQPEINIHTYSSLTCNVTNYDEMKIYNYSNTKFNISISVDGQYFIADIFQFKYESGIIYSENKSTGFPNEMYLGFVVFVIFIALISFAAKNQIEKYFEERKSRKAFRSLDNLRLKLRQKHATEIAKHYTFGEQSAPKPDKSTFYDIRKKLSRLPLIRRCFKEHTD
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Miscellaneous:
MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYLIEILKSIFFGIVEGITEWLPISSTGHLILAEEFIQYQNQNEAFMSMFNVVIQLGAILAVMVIYFNKLNPFKPTKDKQEVRKTWRLWLKVLIATLPLLGVFKFDDWFDTHFHNMVSVALMLIIYGVAFIYLEKRNKARAIEPSVTELDKLPYTTAFYIGLFQVLALLPGTSRSGATIVGGLLNGTSRSVVTEFTFYLGIPVMFGASALKIFKFVKAGELLSFGQLFLLLVAMGVAFAVSMVAIRFLTSYVKKHDFTLFGKYRIVLGSVLLLYSFVRLFV
The following text describes a protein:
Function:
Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKLLIVNADDFGLCKGQNYGIIDAFRNGVVSSTTAMMNSVDINHAAELSAQYPALPVGMHFVLTFGRPLTAMPSLTDANGELGKWLWQRAGAGTLDLNEIAQELECQFERFSAVFGRPPTHIDSHHHVHMLPQIYPLVAAFAREKSLPLRIDRHEVQQHGLTLDNPRSSEWFNAGFYGENLSEPSFLQLLEHADQQGVNSLEIMCHPAFIDQTLMTSGYCYPRLTELAILTSPTLKPAIAQRGYRLGSFLDC
The following text describes a protein:
Function:
Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA.
Subcellular Localization:
Nucleus.
Sequence:
MPNRENGGSSGSGSEEAAGVVEHICRDFLRNVCKRGKRCRFKHPDAVDVSDLGVQKNEFVFCHDFQNKECVRLNCRFIHGTKDDDEYYKKTGELPPRLRHKVAAGLGLSPTDLTNKDEVPICRDFLKGDCQRGDRCKFRHLQREYEHQYDYPCDMRGGMMNMGVSPGSLSAPTTRAYEHYDRYDGLADTEYYSSYYRYGDRLDDPVMKRRRIGYDGYYSGSPVEYRLLEEENVMLRRRVEDLKKQVSVLAATNEVLLDQNAQFRSQAKVVALSTLSATAPTSEQGVGSVTNYNHGIAQTHTTLSSQALQPRAVTQQELVASTGASASAQSNAPQQLNPEITPLSAALAQTIAQSMAPPPVSMAPVAVSVAPVAVSMAQPLPVITMSHASTPMVSYPIVSQSMRITALPH
The following text describes a protein:
Function:
May have a role in maturation, such as during flavor formation or other metabolite production specific to aging tissues.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MIPFLLLVSLPIILFFLLLKAKIGRNSILPPGPLGLPYIGNLHQYDSLTTHIYFWKLSKKYGKIFSLKLASANVVVVSSAKLAKEVTKTQDLAFCSRPSVLCQQKLSYNSYDIALAPYSDYWREMRKICIIHLFSLKKVQSFSPIREDEVSRMIKKISKQAKNSQITNLSSILVSITSTIICRGAFGIRYDEEAQERRKFDELLTETQALLAGFFFSDYFPFLFWFDKISGKINRLEKNFKYLDEFYEGLIEQHLNPNRPKSMEGDILDLLLQLKKEHSTPINITFDNIKAILMVMIYXDTVAISLVWAMTALIKNPKAIKKVQEEIRKSVGKKGMVNEDDIQNFHYLKAVIKETFRLYPPAPTLLARETIQNSILEGYKIPPKTIIYVNYWAIARDPEYWENPEEFIPERFLNSNIDYKGQDFEFIPFGAGRRVCPGIALSVATLELILSNLVYAFDWELPCDMKKEDIDTDVLPGLTMHKKNALCLVPKYYL
The following text describes a protein:
Function:
Endolysin involved in host peptidoglycan digestion after permeabilization of the cytoplasmic membrane by holin. Involved in host cell lysis and liberation of progeny phages. Displays strong lytic activity against chloroform-treated Gram-negative cells.
Subcellular Localization:
Virion membrane; Peripheral membrane protein. Note=May be associated with the viral membrane via P20 and P22.
Sequence:
MQYTLWDIISRVESNGNLKALRFEPEYYQRRMERGDWDNSIIQNIRAANKCSLGTARMIYCSSWGAVQIMGFNLYLNGAFNLSVAHFMENEAYQVNEFRRFLLKNGLTEYTPERLASDKAARVKFAKVYNGAESYADLILQACQFYGVK
The following text describes a protein:
Function:
Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity. During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion. Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate. Exhibits a low antiviral activity against hepatitis C virus. Also acts as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5.
Subcellular Localization:
Cytoplasm.
Sequence:
MEVTTRLTWNDENHLRKLLGNVSLSLLYKSSVHGGSIEDMVERCSRQGCTITMAYIDYNMIVAFMLGNYINLHESSTEPNDSLWFSLQKKNDTTEIETLLLNTAPKIIDEQLVCRLSKTDIFIICRDNKIYLDKMITRNLKLRFYGHRQYLECEVFRVEGIKDNLDDIKRIIKAREHRNRLLADIRDYRPYADLVSEIRILLVGPVGSGKSSFFNSVKSIFHGHVTGQAVVGSDITSITERYRIYSVKDGKNGKSLPFMLCDTMGLDGAEGAGLCMDDIPHILKGCMPDRYQFNSRKPITPEHSTFITSPSLKDRIHCVAYVLDINSIDNLYSKMLAKVKQVHKEVLNCGIAYVALLTKVDDCSEVLQDNFLNMSRSMTSQSRVMNVHKMLGIPISNILMVGNYASDLELDPMKDILILSALRQMLRAADDFLEDLPLEETGAIERALQPCI
The following text describes a protein:
Function:
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRSIIISTTKVGNIEIKDLMVGDEASELRSVLEVNYPMENGIVRNWDDTQHLWDYTFGPEKPNIDTRNCKILLTEPLMNPTENREKMVEVMFETYQFSGIYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIYPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLQGYTFNHSADFETVRMIKEKLCYVGYNIVQEVYYVSWPVIMVERELKQLYLERVLKDDVEKLPKFKICIEDPSRRKHMVFLGGAVLVDIMKDKDNFWMTRQEYQEKGVLVLKKLGVTVR
The following text describes a protein:
Function:
Possibly involved in cell adhesion.
Sequence:
MELSSVLPCKRCTPWRGLLLTASLLTCWLLPTTAQVSIESLPPQVVEGENVLLHVDNLPENLIAFVWYKGLTNMSLGVALYSLTYNVTVTGPVHSGRETLYSNGSLWIQNVTQKDTGFYTLRTISNHGEIVSNTSLHLHVYFSTLTCGRAATSAQLSIESVPTSISKGESALLLAHNLPENLRAIFWYKGAIVFKDLEVARYVIGTNSSVPGPAHSGRETMYSNGSLLLQNVTRNDAGFYTLKTLSTDLKTEIAYVQLQVDTCFMSYAGPPTSAQLTVESAPTSVAEGASVLLLVHNLPENLRAIFWYKGVILFKDLEVARYVIGTNSSVLGPAHSGRETMYSNGSLLLQNVTRNDAGFYTLRTLSTDLKAKVVHVQLQVNTSSCCDPLTPALLTIDPVPRHAAKGESVLLQVRNLPEDLRMFIWFKSVYTSQIFKIAEYSRAINYVFRGPAHSGRETVYTNGSLLLQDATEKDTGLYTLQIIYRNFKIETAHVQVSVHTCVHPSTTGQLVIESVPPNVVEGGDVLLLVHNMPENLQSFSWYKGVAIVNRHEISRNIIASNRSTLGPAHSGRETIYSNGSLLLHNATEEDNGLYTLWTVNRHSETQGIHVHIHIYKPVAQPFIRVTESSVRVKSSVVLTCLSADTGTSIQWLFNNQNLRLTQRMSLSQTKCQLSIDPVRREDAGEYRCEVSNPVSSKTSLPVSLDVIIE
The following text describes a protein:
Function:
Final receptor of the osmolarity two-component system regulatory system, which controls activity of the sakA mitogen-activated protein kinase (MAPK) pathway in response to changes in the osmolarity of the extracellular environment. Regulates the germination in the airways that drives enhanced disease initiation and inflammation in the lungs.
Subcellular Localization:
Cytoplasm.
Sequence:
MPDRRLSQLLKSKLLRRSSTTATTSPKQNQKPVNAQKKAAVGADPLVDPNSTSDLSCSLPPHLLTSNEGEGDAKSRAYSIISSIPLDHPSSPDEIPGPATGSSAGCEQYFTHFDRSGANSRQEGSQNGSIQQSPTFTRTLRHKQLTEEKDKGKLQSREGDQRGEYGYQRIRNDSNDSDPQYSLTTELANKPSTPQTPAGDDSLHSPSATPLPLSPSLPGPTGASSLQAAYRPVRENSSVPLVESQLTPSLGAVAEDSSGESAFHFVGPSSSSPFPKRPPLGFRRQSLLPASHQHLISGLLGFGPSQNLGQGSGHPSTVNADMIPRKVWVKRPGGSATLVPTMEDSLVDELRDQVIMKYANSLGRTFDSPDIMIRISPREGSNRQSTPERILSPEEPLGVVLDTYFPGGQTVDEALVIDIPQRRTPKPSPRHPVYYHHSEPGEHGEYFPLMPANPNAPTPPTHPSASSTSVNAHHTGPSISILTTDSNMASCPQPPVAAPQVPTPPGPPPESPQTKTHTPPARVASPRPRPTKPKKAGNGQSPNAAFGGLIEGTVPPINVLIVEDNIINQKLLEAFMKRLSVRWKCAANGEEAVRKWREGGFHLVLMDIQLPVMNGLDATKEIRRLERLNGIGVFTKTASGRSSASSLSPEVNQASSEVSLSEEDTLHDLSLFKSPVIIVALTASSLQSDRHEALAAGCNDFLTKPVGFPWLEQKVTEWGCMQALIDFEGWRKWRGFADEPQSSSPTDGGFTSPLQAGANGVSSRTSTSPSSAAVNATARAFATGPGAGKRKSTVPELTKPVDILPEEPPGSGSGEGNETLDSPASPLTSVHVGDPTEPPGDEEQQALDAT
The following text describes a protein:
Function:
Transcription factor that functions as a repressor of flowering by enhancing the expression of several genes that delay flowering including FLC, FLM/MAF1, MAF2 and SVP. Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA. Functions in association with HUA1 and HEN4 in AG pre-mRNA processing. Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression. Acts as a transcription regulator that controls anthocyanin accumulation.
Miscellaneous:
MISCELLANEOUS: In cv. Sy-0, a naturally occurring allele K525E, termed ART1, together with active FRI and FLC alleles causes delayed flowering of primary and axillary meristems, resulting in the distinctive Sy-0 morphology.
Subcellular Localization:
Nucleus.
Sequence:
MAPGRKRGASKAKAKGQLVLGDLVLAKVKGFPAWPAKISRPEDWDRAPDPKKYFVQFFGTEEIAFVAPPDIQAFTSEAKSKLLARCQGKTVKYFAQAVEQICTAFEGLQNHKSNALGDEDSLDATEPGLTKAEIVDGTDHIVIESERTDNFNFRVDPCFPKLDENNGEERKAEIRKLDSSSFLESKVKTTSPVSESLEHSSFDPKIKKEDFDKGTDGSACNEHFGNGQKKLANGKRIKKEAGGSDRKGEDTVHRDKSNNSHVPGGRTASGNSDSKKSKGLLTEKTSSKVSADKHENSPGIKVGVSGKKRRLESEQGKLAPRVDESSRAAKKPRCESADNKVKCEIDDGSDSTGTVSDIKREIVLGLGARGGNFQYDKEAVAYTKRQRQTMEHATSPSFSGSRDKSGKGHLEQKDRSSPVRNVKAPAAQSLKKRRAVCIYDEDDDEDPKTPLHGKPAIVPQAASVLTDGPKRANVCHSTSTKAKISAGSTESTEVRKFPLRKHCEDASRVLPSNAENSTNSLPVVKPINELPPKDVKQILQSPKMSPQLVLTNKHVAGQHKVVKSSVKVSGVVMAKKPQSDSCKEAVAGSDKISSSQSQPANQRHKSASVGERLTVVSKAASRLNDSGSRDMSEDLSAAMLDLNREKGSATFTSAKTPDSAASMKDLIAAAQAKRKLAHTQNSIFGNLNPSFLSISDTQGRSHSPFMVQNASASAAISMPLVVQGHHQQGSSPSNHGHQSLSRNQIETDDNEERRLSSGHKSVGGSLSCSTEAAISRDAFEGMLETLSRTRESIGRATRLAIDCAKYGLASEVVELLIRKLESESHFHRKVDLFFLVDSITQHSHSQKGIAGASYVPTVQAALPRLLGAAAPPGTGASDNRRKCLKVLKLWLERKVFPESLLRRYIDDIRASGDDATGGFSLRRPSRSERAVDDPIREMEGMLVDEYGSNATFQLPGFFSSHNFEDDEEDDDLPTSQKEKSTSAGERVSALDDLEIHDTSSDKCHRVLEDVDHELEMEDVSGQRKDVAPSSFCENKTKEQSLDVMEPVAEKSTEFNPLPEDSPPLPQESPPPLPPLPPSPPPPSPPLPPSSLPPPPPAALFPPLPPPPSQPPPPPLSPPPSPPPPPPPPSQSLTTQLSIASHHQIPFQPGFPPPTYPLSHQTYPGSMQQDRSSIFTGDQIVQGPGNSSRGGLVEGAGKPEYFVQQSSSFSPAGVCSSREPSSFTSSRQLEFGNSDVLFNPEASSQNHRFQPSTPLSQRPMVRLPSAPSSHFSYPSHIQSQSQHSYTHPYPFPPQRDDARRYRNEEPWRIPSSGHSAENQNGAWIHGRNSHPGLPRVTDSFFRPPPERPPSGTMNYQPSAASNLQAVPAIPGHTAPQMLPSRPDIPTVNCWRPA
The following text describes a protein:
Function:
Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPRILAATAGSFVLKAYFHRWRSLVILALLLAPLLWPLQYFAERYYSEQLAEQNRQTLDLYVANLLGTLRRYEELPQILGGLPVLRQALQQPGDPLLQKIANEALADIRRRTGADVIYLLQPDGTTQVASNWAQADSFVHRNFAFRPYYREAMQGRLARFFGLGTTSIKRGYYFASAVKEGSRIIGVLVVKVDLEHIERLWGNSPEQLLVIDNYGVVILSSREDWRFHASRPLSAAERDEIHANIPYPVQDPKPLRLQQSAWLSQSRTLPETGWTVSIYAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEERVLERTRELENANAQLQQEVHEREQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQPAIEDALSMVASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAEKAPPRRLWVIASQDQHGVTLTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHLLPGVPGVAAMPQEETRA
The following text describes a protein:
Function:
Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin (By similarity).
Miscellaneous:
MISCELLANEOUS: The activity of the BasR protein is in some natural isolates, but not in strain K12, controlled at a post-transcriptional level by the PmrD protein under low Mg(2+) concentration conditions.
Subcellular Localization:
Cytoplasm.
Sequence:
MKILIVEDDTLLLQGLILAAQTEGYACDSVTTARMAEQSLEAGHYSLVVLDLGLPDEDGLHFLARIRQKKYTLPVLILTARDTLTDKIAGLDVGADDYLVKPFALEELHARIRALLRRHNNQGESELIVGNLTLNMGRRQVWMGGEELILTPKEYALLSRLMLKAGSPVHREILYNDIYNWDNEPSTNTLEVHIHNLRDKVGKARIRTVRGFGYMLVANEEN
The following text describes a protein:
Function:
Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MPWLSGGRRRRRGQPREAPREPPPSAQPQREPPPAPPAAVPTPPAPSAPPPRARESAELPLPAGWEEARDYDGRVFYIDHNTRQTSWIDPRDRITKPLTFADCVGDELPLGWETVYDKQIGVYYMDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCEDDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLADSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPFVRSGTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQSCRSSLAELMARTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQLRGQTDLPPWVLRDERLRGLLREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEPIQVQTFREKIAFFTRPRINIPPLPADDV
The following text describes a protein:
Function:
Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects; Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.
Sequence:
QRVLVIGAGSSGLVALKECLAEGFSNVVCYEALANLGGLWQYEPVQPNQKVHSSVYKNTVIDTSKQMMAFSDFPIPHHWPIYLHNKSVVKYYHMYAEKFDLINHIEFNTQVTAIDPLKSTTNDLQASKPYNGQWRVEYMQDGNQLTAVFDKVIIASGHHWKPKMPEFPGMNEFKGEMMHSHYYREANPFKDRQCLVVGLGNSAVDVAVELSYHAKQAYVSSRRSAWLMSRFSLNGRPLDQTVSRFYTMLPIFIRNILVRFTTWVQLGDIAQFGLFPKHEPFSAHPTISSELPGRISTGTIVMKPNVKRFYRLADRQMVEFEDKSSVPVDTVIFCTGYEIGYPFLDAEKIVGLNNPGSNVVDLYKLVWPVHYDSIAFVGLFQPLGAIMPGSELQSRWIARTWSGQCSNLPNANIRLEDIYKKRAQVRQRYVTSPRHTIQVDAGTYFDEIAGQFGAAPNLWLLFFSDIFFWWKIVFGCWNAHQYRLSGPGAWTGAKQAI