lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.
Subcellular Localization:
Nucleus.
Domain:
MBT repeats have unique discriminatory binding activity for methylated Lys residues in H3 and H4; the MBT repeats bind mono- and dimethylated H3K9Me1, H3K9Me2, H4K20Me1 and H4K20Me2 but fail to interact with these residues if they are unmodified or trimethylated.
Sequence:
MNPSELRMMWMSSQYNSERITLEDAATLLGHPTVGLSVMEDLSAHQPTLDMNPMMSLMGGDFTGQAAATAAALGVQPGTLIATNSNNLYGFAHMGGLQQQLLQQSAAAAVFQNYAEAMDNDVENGMVGMAMEAVVDDDDQVYGQRDNNFDDNGSELEPKQEIINIDDFVMMNEDNNSYDGTDFMTSSDKDISQSSSSCMAQMPGSLGVPGVEHDLLVPLPDGLLHHKLLGTTLVPAMGTLNGNAFGNIMVSTENTSSKQMQRTYSTAKGANSTATTATCSASTSSALRSQRKTRKIEPVNRPGLVLKTPIAYRGNIDPSVIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELYSLVLNTKMEGDQATTSSPDPGAGSESADLPGDQQQSQSDIELDLHAAHIKNANYRFRITDQSKITQLNSFGEPMSMGGDAAANNVQMAADETIAALNGGAVGDATAPGSTEEGASTPNSYLSAAPTPKALRLFKDIYPQDDLPQIPKYERLPVPCPQMEKIISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGMKVEVENTDCDSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWCATRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQSRFRLGLNLECVDKDRISQVRLATVTKIVGKRLFLRYFDSDDGFWCHEDSPIIHPVGWATTVGHNLAAPQDYLERMLAGREAMIEVHEDDATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGPPRVAHQQAPKPAPKPKIQRKRKPKKGAAGGKTPTDNNTQSVKSRTIALKTTPHLPKLSIKLELKPEHHNAAFYENNQPEEEGDEEDPDADGDGDGSTSHISEQSTTQSSSDLIAGSGSGSGSASLVTLATGSNKTNSSATNNKYIPRLADIDSSEPHLELVPDTWNVYDVSQFLRVNDCTAHCDTFSRNKIDGKRLLQLTKDDIMPLLGMKVGPALKISDLIAQLKCKVNPGRARSHKTNKSPFL
The following text describes a protein:
Function:
Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone atx1 and incorporates it into trans-Golgi vesicles (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MYTTTLSVQGMTCTSCVASIQSMLEGVEGIEQFTISLLLERAIAVHDPSIISPDQIAEKIEDCGFDASVISSTEGEHGVMANYLLLSPMQAEQWTKVHNHINELQGVLSVNCSSSPDAAIRVIYDSEITGPRSIMKEILSMGVKCTFQPVDSSTSRILSLQRGSQIRVWKIRFIISISFSLAVMFLPQIFDSCDSMRAAFLVPHYFGICAGHIISLVLSLPVQFGVGRVYYSAAYHALKRGTANMDVLVSLGSTVAFAASIFFMILYSARHADNPAPIFFDTADMLLTFVTLGRYLESKAKGSTSAALSQLLSLAPSSATIIEDNEQIEILADLIERGDLILVKPGEIIPVDGTVVEGSSYVDESSVSGEPVPVHKTIDDELLSGTANGNGRLLVKATKSPRESQLAVIVDLVQRAQISHAPIQQFADRVAGIFVPVIVALSISTFTFWFLFTKYSSKYPSVFDDPMGKFAVCLKLTISVVVVACPCALGLSTPTAVMVGTGVGALNGIIIKGGEILERLNQVDTVVFDKTGTLTVGKLSVTDISIVDNLEELLDIPKNIFWAFVKASESSSEHPIGKAITEKASEFTDVSEIGIESFNAVPGEGVDVVLRWKERTFHALLGNSLLLEHNNVSIPDDFDSKLKLSSSSGLTCVRIAIDGQFVGFLGCMDQVRPDSYQTVSALKQLGKKVCLLTGDQKATARRVAQGLEIDFSDVYAEAVPSQKAEIIQKLKDQKHCVAMVGDGINDSPSLVLADVGIAPINGSGIALESADVILVRKGVLLDTAVSFDLSRVIVKRIKMNLVWACIYNFVMIPIAMGFFLPWGIYLNPMWASAAMMFSSLSVLASSLLLRRWKKPKSLIFSEADDVETESSTNSSVLQKVYTATRSIFGRNKSSNKYQPVANEV
The following text describes a protein:
Function:
Plays an important role in the immune response against parasites by acting as a receptor of IL9.
Miscellaneous:
MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MGLGRCIWEGWTLESEALRRDMGTWLLACICICTCVCLGVSVTGEGQGPRSRTFTCLTNNILRIDCHWSAPELGQGSSPWLLFTSNQAPGGTHKCILRGSECTVVLPPEAVLVPSDNFTITFHHCMSGREQVSLVDPEYLPRRHVKLDPPSDLQSNISSGHCILTWSISPALEPMTTLLSYELAFKKQEEAWEQAQHRDHIVGVTWLILEAFELDPGFIHEARLRVQMATLEDDVVEEERYTGQWSEWSQPVCFQAPQRQGPLIPPWGWPGNTLVAVSIFLLLTGPTYLLFKLSPRVKRIFYQNVPSPAMFFQPLYSVHNGNFQTWMGAHGAGVLLSQDCAGTPQGALEPCVQEATALLTCGPARPWKSVALEEEQEGPGTRLPGNLSSEDVLPAGCTEWRVQTLAYLPQEDWAPTSLTRPAPPDSEGSRSSSSSSSSNNNNYCALGCYGGWHLSALPGNTQSSGPIPALACGLSCDHQGLETQQGVAWVLAGHCQRPGLHEDLQGMLLPSVLSKARSWTF
The following text describes a protein:
Function:
Hydrolyzes both GDP-mannose and GDP-glucose. Could participate in the regulation of cell wall biosynthesis by influencing the concentration of GDP-mannose or GDP-glucose in the cell. Might also be involved in the biosynthesis of the slime polysaccharide colanic acid.
Sequence:
MFLRQEDFATVVRSTPLVSLDFIVENSRGEFLLGKRTNRPAQGYWFVPGGRVQKDETLEAAFERLTMAELGLRLPITAGQFYGVWQHFYDDNFSGTDFTTHYVVLGFRFRVSEEELLLPDEQHDDYRWLTSDALLASDNVHANSRAYFLAEKRTGVPGL
The following text describes a protein:
Function:
Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric oxide since cytokinin breakdown products synergize with NO to kill M.tuberculosis. Shows a slow AMP hydrolase activity, but is not able to hydrolyze ATP. Displays no lysine decarboxylase (LDC) activity (L-lysine conversion to cadaverine).
Sequence:
MSAKIDITGDWTVAVYCAASPTHAELLELAAEVGAAIAGRGWTLVWGGGHVSAMGAVASAARACGGWTVGVIPKMLVYRELADHDADELIVTDTMWERKQIMEDRSDAFIVLPGGVGTLDELFDAWTDGYLGTHDKPIVMVDPWGHFDGLRAWLNGLLDTGYVSPTAMERLVVVDNVKDALRACAPS
The following text describes a protein:
Function:
Essential for normal male fertility and for progressive motility of spermatozoa.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme.
Sequence:
MASKSKHVKVVIRTRPTSSFAQDIINFGDDKLSLHIHIPKNEEWGFINNQQENWDFKFDNIMHNASQEAVYDHCGGPIIKSLLDGYNATIMAYGQTGAGKTFTMTGASENYKHRGLIPRAISHVFHEIAQRPNFSFNIRISYLEVYNEQMIDLLASISGNLNNESLAVVEEKSGSTYVKGLNIQNANNEEEALNLLFEGETNRSRSEHQLNKCSTRSHCIFTLYIESRSNIESSEKIITSKLNLVDLAGSERLSKTETKGKSLKEATYINRSLTYLEQVIIALADRKRDHIPFRQSKMTHVLRDSLGGNCNTLMIANIWGEKEHIEETISTLRFATRMMCVSTTPEINVHYDPQALIKKYEREVKELKQELSMHDTLCNRSHVQYEPFSEAQRHELSKLVKAYIDNEADEIEIVNLRQIREILSIFRLMYRNMEAEMDDAVQRTHKQTTFNVTNVRDPAGEQHSDVGGGAGRKQGVYEPDRDDGVGEIESSGFGIGLAPSGTKHLPGSGSAALLRSGQPLNPQSRLAGTVTAKRDRKATMLSVGNRDTDEIAQDVLPISEDVECNPRQDESIINFESGQGANIGVGSVVTDSGGIVRDRRYGSTPLSRADEFESFKRGRGLEMNHILTDNKLALKEKRRMAKELAESANQIKRKIDEIKEHLEQKKDAHVRDGEDIIIDEDEYTLTNTLKRFKEQYKEKFDSLRVTRTEVEYCTRMTDQSRQKLMTEFEQWYESIYGAQITENGNGGVEDALDIGEKFDRLQLERMSQEDPDSLPYYNALKNTERRSQKGAIKRNTNNALSPIVGMRSGGMLLKQLPPVGIRSSANSTLMIRKS
The following text describes a protein:
Function:
Associated with the mammalian reproductive process. Plays an important role in the formation of the seminal coagulum through the cross-linking of specific proteins present in the seminal plasma. Transglutaminase is also required to stabilize the copulatory plug.
Subcellular Localization:
Secreted.
Sequence:
MDSRNVLIIYAVNVERKLNAAAHHTSEYQTKKLVLRRGQIFTLKVILNRPLQPQDELKVTFTSGQRDPPYMVELDPVTSYRSKGWQVKIAKQSGVEVILNVISAADAVVGRYKMRVNEYKAGVFYLLFNPWCSDDSVFMASEEERAEYILNDTGYMYMGFAKQIKEKPWTFGQFEKHILSCCFNLLFQLENNEMQNPVLVSRAICTMMCAANGGVLMGNWTGDYADGTAPYVWTSSVPILQQHYVTRMPVRYGQCWVFSGILTTALRAVGIPARSVTNFESAHDTEKNLTVDIYLDESGKTIPHLTKDSVWNFHVWTDAWMKRQDLPHGYDGWQVLDSTPQEISDGGFRTGPSPLTAIRQGLIQMKYDTTFVFTEVNGDKFIWLVKQNQEREKNILIAVETASLGKKISTKMVGENRREDITLQYRFPEGSPEERKVMAKASGKPSDDKLNSRTLNNSLQISVLQNSLELGAPIYLTITLKRKTATPQNVNISCSLNLQTYTGNKKTNLGVIQKTVQIHGQESRVFLTMDASYYIYKLGMVDDEMVIGGFIIAEIVDSGERVATDTTLCFLYSAFSVEMPSTGKVKQPLVITSKFTNTLPIPLTNIKFSVESLGLANMKSWEQETVPPGKTITFQMECTPVKAGPQKFIVKFISRQVKEVHAEKVVLISK
The following text describes a protein:
Function:
Probably forms vertices in the bacterial microcompartment (BMC) dedicated to ethanolamine degradation (Probable). It may be involved in transporting positively charged molecules into and out of the BMC (Probable).
Subcellular Localization:
Bacterial microcompartment.
Sequence:
MKLAVVTGQIVCTVRHHGLAHDKLLMVEMIDPQGNPDGQCAVAIDNIGAGTGEWVLLVSGSSARQAHKSETSPVDLCVIGIVDEVVSGGQVIFHK
The following text describes a protein:
Function:
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus speckle. Note=Shuttles between the nucleus and the cytoplasm (By similarity). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (By similarity).
Sequence:
MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDVKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPPSGRMRPY
The following text describes a protein:
Function:
Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Negatively regulates primarily iron-dependent mitochondrial processes including respiration and amino acid biosynthesis.
Sequence:
MMPNVAPNSYYLNIPNANSTSTTTSSIFSDLNKEYESKIKEIEEYYIKTLLNENTDNDDSSSSEGHNINETDILSEYSPRPSPWLPSKPNCYHPLGDFKDLIISDSRPTNTLPINNPFAGNNNISTLATTEKKRKKRSLEVEINPTYTTSAFSLPLTAENLQKLSQVDSQSTGLPYTLPIQKTTKLEPCRRAPLQLPQLVNKTLYKTELCESFTIKGYCKYGNKCQFAHGLNELKFKKKSNNYRTKPCINWSKLGYCPYGKRCCFKHGDDKDVEIYQNANDGRSKDTALTPLPTSLAPSNNDNITNLSKPRNLHTSVKALQRMTW
The following text describes a protein:
Function:
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Membrane; Single-pass type I membrane protein. Mitochondrion.
Sequence:
MVAYTTATATPNLSHVFFWLLIFAPFPPPLTRWGQAEASVQEEKLSVSTSNLPSWLVEEFVVAEECAPCSNFQSKTTPECGSPGYVEKIMCSSSKRIEFNSCCSALMEQHLFWKFWKFEGAVVGVALVFACLALEKVRQQTESISLPSPLFIRVSETLSQRKRNGLTCAPGSLEPCDGTPFHPPSSAKSLNE
The following text describes a protein:
Function:
The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MDFYTPPTTAGPPTRGSPESVPTTAASTFPLRKRTRAHLRARDKSDGPAPSSRGTSDRLWSWVFLKQPLSLPEHNYQAHLGNNVFLIGGRFLSARQKPLNIAVLCVILILGGLYYGFVAPWTWNHISPAIPAVFTYIFLLCVASFLRASFSDPGILPRNIHLTDRIADGSIPNEYSVEPGIDAFDPRKNTTSLSCFKQPESSENLVYLKYCSTCKIWRPPRASHCSDCDNCVDFHDHHCIWLNNCVGRKNYRYFVAFVMTGGLCGLYIVGNSIAHVICYKRHMHMTIAESLRHRPMPLVMIFLGFLGAGYPLALVGFHLWIASRGESTHEFVSMNPVTKHVVDGHVGVTLSKCKVMGSHDGFKRFSDAVLAVVCARLCAHVSPHSNPVTKQTTPQGVQKSTFRHWKRF
The following text describes a protein:
Function:
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By similarity). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDSRLQEIRERQKLRRQLLAQQLGAESADSIGALLNSKDEQREIAETRETCRASYDTSAPNAKRKYQDEGETDEDKMEEYKDELEMQQEEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR
The following text describes a protein:
Function:
Promotes the eIF4F and eIF4A RNA-dependent ATP-hydrolysis activity with different efficiency depending on mRNAs, thus providing mRNA discrimination during initiation of translation.
Subcellular Localization:
Nucleus.
Sequence:
MAKPWGGVGAWALDAEREDEEREHAAAFPAPDPPAAAGGAASFPSLKEAVVAGGGKQKKKKGTTLSLSEFTTYGAAGAPRRVAPAEPKGLTPQEMMMLPTGPRERSEDELDRSRGFRSYGGDREPRGGGFDDDRRSSRDSDLDMPSRADESDNWGKNKSFSPAPTDSGRRDRLSGPSPLGRSDDIDNWSRDKKPLPSRYPSLGTGGGFRESSGGGFRESSGGGFRESSGGGFRDSPGPSDSDRWVRGAVPAPMTNNGDRPRLNLNPPKRDPSATPVPAAEVARSRPSPFGAAKPREEVLAEKGLDWRKMEGEIEKKTSRPTSSHSSRPNSAHSSRPGSPGSQVSAVGSEGAPRARPKVNPFGDAKPREVVLQEKGKDWRKIDLELEHRAVNRPESEEEKNLKEEINLLKVDLKEIEAIAGDGSEQAKEVSEKISQMEKQLDLLTVELDDKIRFGQRPSSGAGRAAAFPPASEEPHVAVAHMDRPRSRGGVETYPKPVEERWGFHGSRERGSFGGGGSSDRSSTRQGW
The following text describes a protein:
Function:
Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Nucleus envelope. Golgi apparatus. Cytoplasm. Note=Weakly expressed in the cytoplasm.
Sequence:
MMQGEAHPSASLIDRTIKMRKETEARKVVLAWGLLNVSMAGMIYTEMTGKLISSYYNVTYWPLWYIELALASLFSLNALFDFWRYFKYTVAPTSLVVSPGQQTLLGLKTAVVQTTPPHDLAATQIPPAPPSPSIQGQSVLSYSPSRSPSTSPKFTTSCMTGYSPQLQGLSSGGSGSYSPGVTYSPVSGYNKLASFSPSPPSPYPTTVGPVESSGLRSRYRSSPTVYNSPTDKEDYMTDLRTLDTFLRSEEEKQHRVKLGSPDSTSPSSSPTFWNYSRSMGDYAQTLKKFQYQLACRSQAPCANKDEADLSSKQAAEEVWARVAMNRQLLDHMDSWTAKFRNWINETILVPLVQEIESVSTQMRRMGCPELQIGEASITSLKQAALVKAPLIPTLNTIVQYLDLTPNQEYLFERIKELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSAIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCIYQSAINPPHYELIYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE
The following text describes a protein:
Function:
Transcription factor required for the development of the heart and the spleen. Implicated in commitment to and/or differentiation of the myocardial lineage. May regulate the expression of genes involved in cardiogenesis and play a role in the formation of gut and the pharyngeal region. Binds to the core DNA motif of promoter.
Subcellular Localization:
Nucleus.
Domain:
The homeobox domain binds to double-stranded DNA.
Sequence:
MFASPVTSTPFSVKDILNLEQHQSGLSPMDITSRLENSSCMLSTFKQESYPGTPCLSELTEEMSQRDTAKGPSSFPGSFFVKNYLEMDSKDPKDHKKDICPLQKTLEHDKREAEDPERPRQRKRRKPRVLFSQAQVYELERRFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRRYKCKRQRQDQTLEMVGLPPPRRIAVPVLVRDGKPCLGESSPYNSPYNVSINPYSYNTYPAYSNYSNPACSGSYNCSYSSMPSMQPTSAGNNFMNFSVGDLNTVQTPIQQASSVSALHHGIRAW
The following text describes a protein:
Function:
Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals (By similarity).
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MKKILNFIVEINLAIIISLFTSDFILWFAIILLLILAWHHINEYRLLKYLNLKQDNKFSLLQLGTFSQTEAYHRHQIYKEKCASLRLLSQINKNIKYLPDAIIICQHNGNISWCNSIAPQMFDFCWDKKVQENIFDVIFYEQFKHYFFSPKKRRPLVLLTYNQRYIEVQSHAYNSHMILVIARDITDMIHLLNSRQKFLSNINHELRTPLTVLQGYLEILADNNIQNPLQKKAIXAMQEQSQRMEHLLQQFNFLAKIETTSDKDFRKFDMSAMINSLRKDTDILNTYNHHIEFIIQPNIIIFGNESQLRSAVSNLIYNAIKHSGKQCHIQIQWETCEQGIKFNVIDNGVGISPQHIPHLTERFYRVDESRSHLTGGSGLGLAIVKHTLLQYHSHLNIESTETKGSSFSFIIPKRFVISKNNKEIQ
The following text describes a protein:
Function:
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Subcellular Localization:
Cytoplasm, nucleoid.
Sequence:
MFGKAGLGGLMKQAQQMQENMKKAQAKLAETEIEGEAGNGLVKITMTCAHEVRKIDISPDLIQEAADDKEMLEDLILAALKSARGKAEETANKTMGAFTQGLPPGVGDFFR
The following text describes a protein:
Function:
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Sequence:
MSASETTPQSNHGIGILGGSFDPVHVGHLWMAESALEQLPIEHVRWIPAATSPLKPHGPVASNEHRLQMLRLALSGQSGLVIDDWELRQDSVSYTLLTLEYLQEQFPDRPLYLIIGADSLASFDRWREPEQILKRCHLAVIARGGDPPPDYSILDGMTDETQIQRIRESQIQMPQIEISSSDLRNRIATGRSIRFRVPHPVATLIDNEKMYRVR
The following text describes a protein:
Function:
Plays an olfactory role that is not restricted to pheromone sensitivity.
Subcellular Localization:
Cell membrane.
Sequence:
MRDFASLFGSQYQTIFGGSPSCAGGSLGGSSSGSSSSGDCCSSSGGGGSSGTSQRRRSVSLGPFRRRIRSEFSLLDYFFHQPKHGRHTRYPNRTFMLMAAGFMFIICGALIHILDPYLLIFKWKLIFQEGSEIFNLWRTPPVDLYIKIYLFNVTNAEDFMAGRAEKMQIEEVGPYVYRELMSHDNITFNDNGTVSTRPHHPLIFQKGMSGNLREDDVFMMPNIALLSIAHVAAKQPYFIRWPINLLIRQTKVQPLERQTAREFMYGYPTTLTTLGYTFLPNWISFDKVGLIDRMYDFDDDFETFYTGETTASVSGLYDTYLGSPDLAQWNGSHCSNIRNASDGTKFKSFIEPDDQLLFFRKSMCRAQILIQNGTDYEVDGLKATKFVFEENALDNGEYDPRNKCYCRKGNCLPRGLIDVTSCYYGFPIALSYPHFLDADPKVRSHVNGSRPDPTAHRSHFMINPISGLPLELSVKFQINMVLDDLSSMAHCEKFSKLVVPALWFEIMMPGLPPTLLSRFLFYLKILPFGDQVVKHSLLAFGGILLLVAITKVSLTLSSAYSSAYRISNELRESLW
The following text describes a protein:
Function:
Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.
Subcellular Localization:
Nucleus.
Sequence:
MAACVAGTPRRVKSLLSSFLHSSSTNDHQRLYQIPVAKTCLQLKDSLVAGHTKFCPWPDNPCPESFLGLPTNTPVQWKEDFRMRCQALLDLGASLPLLDSLTYKDMDEVTEDGLEQLQKAFQSCDQGMMDEEDMEQAVRTSCVVALCGWKYRPSDTDADGHTLFCTMCRREVGLWNFKSLTSPSPSASPCSSGRLDDPSGPLEAMSMSDDIVTDSSSLPGSERLMPQDSMEVAKKGFIRSPIGLKRSRDTESSGQEHEIDTISDSEEHKMEMEMKHRLQGEEESPQQDSTQGLTHATREETQDMRTTDWAMVVGDNQSKEGLTRELLQLPLHVRPLSGRSSPISGRYGSENLSYRSPLHHSLSDLSDKGHCESLCVEVEDESLTEKLQAVESELEFMSGGNDSSDRGEYTPERKRIRLQDIEKGTFNPISEHRSWCPWVTCSVKDRGRSSNDQGTNVGWKMLLHTILPNLGSGKEHSYVESPPQDAWKSVRRVLNEGSSSTSSRSDNHSK
The following text describes a protein:
Function:
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Sequence:
MKTALLLKTKSQPFDPYVEAFEKYGRDTAFIPVLRHKRVHEEQLRDKLKNVRKTYCGLIVTSQRVSETLDEALKQEDETERQKILMETPIFTVGPATDDSIRRLGFQQTHGKDCGRGEVLADLIEEWYTTTKQHKPLLFLVGEKHRDIIQRKLGDDRVDSLIVYATQELENTETQIKDTIRKHPTIDWIVAFSPTSICSLLNTFELKIATIGPTTGDYLKKLGTQPNVVSPAPNPESLASSIVAFDEENSS
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
Miscellaneous:
MISCELLANEOUS: Present with 2170 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTISEARLSPQVNLLPIKRHSNEEVEETAAILKKRTIDNEKCKDSDPGFGSLQRRLLQQLYGTLPTDEKIIFTYLQDCQQEIDRIIKQSIIQKESHSVILVGPRQSYKTYLLDYELSLLQQSYKEQFITIRLNGFIHSEQTAINGIATQLEQQLQKIHGSEEKIDDTSLETISSGSLTEVFEKILLLLDSTTKTRNEDSGEVDRESITKITVVFIFDEIDTFAGPVRQTLLYNLFDMVEHSRVPVCIFGCTTKLNILEYLEKRVKSRFSQRVIYMPQIQNLDDMVDAVRNLLTVRSEISPWVSQWNETLEKELSDPRSNLNRHIRMNFETFRSLPTLKNSIIPLVATSKNFGSLCTAIKSCSFLDIYNKNQLSNNLTGRLQSLSDLELAILISAARVALRAKDGSFNFNLAYAEYEKMIKAINSRIPTVAPTTNVGTGQSTFSIDNTIKLWLKKDVKNVWENLVQLDFFTEKSAVGLRDNATAAFYASNYQFQGTMIPFDLRSYQMQIILQELRRIIPKSNMYYSWTQL
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Subcellular Localization:
Cytoplasm.
Sequence:
MPYYRTWEEFTRAAEKLYQADPMKVRVVLKYRHCEGNLCIKVTDDVVCLLYRTDQAQDVKKIEKFHSQLMRLMVARESRSAAMETD
The following text describes a protein:
Function:
Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKIISKKYRLELYSMLVDLLNDNIPLYDALNKIQNEGVGIYDKNFIKSIELIKDRMKSNSSLTDALTGLIPDKEVLMINVAENSGKISSGIAAIRKNIIDADEIKSKAISSMITPSVMLIVTMVVIAGYSVKVFPTFESVLPVSRWPGVTQALYNLGFSLYEGLWIKVLIFVAIFITILVFMSKNITGNFRDGFLDKLPPFNFVKHIAATEFLANMSMLLDSRVPFKEGLDIVDHKTTRWLSSHLQRMKANMQEGLDYKQALDTNLLDKKMLLTMAVYSELPNFSDVMQKLAIEANINLHKKIATLAGVMKNISLITLALSVIWIFGAIFSLVDKLSSSL
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Cytoplasm. Mitochondrion matrix.
Sequence:
MIDDNIENNEQTINDIAEEIVETANPEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKPANSDIEVTNIIAGVQMTKDELDKIFHKHHIEEIKPEIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLLRPATVQVAKKS
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD2.
Sequence:
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAIDILAVRHGMENPNAVEAEISGRTFE
The following text describes a protein:
Function:
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
Sequence:
MFGLEKPPGQQKLGRSGGFPNMASVGDFNVLSSSIPATKVELSVSCRNLLDRDTFSKSDPICVLYTQAIGNKEWREFGRTEVIDNTLNPDFVRKFIMDYFFEERENLRFDFYDVDSKSPNLSKHDFLGQMFCTLGEIVGSQGSRLEKPIAGIPGKKCGTVIVTAEELGCCRDSVLMQFCANKLDKKDFFGKSDPFLVFHRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFNVYEVINPKKKGKKKKYVNSGTVTLLSFLIETEVSFLDYIKGGTQINFTVAIDFTASNGNPSQPTSLHYMNPYQLNAYGMALKAVGEIIQDYDSDKMFPALGFGARLPPDGRVSHEFALNGNPQNPYCHGIDGVMEAYYRSLKSVQLYGPTNFAPVINHVARYAASVKDGSQYFVLLIITDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMEELDGDVVRISSRGKFAERDIVQFVPFRDYIDRSGNHVLSMARLAKDVLAEIPDQFLSYMRVRGIKPSPAPPPYTPPIHVLQTQI