lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus.
Sequence:
MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAEVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH
The following text describes a protein:
Function:
Has antibacterial activity, mainly against marine Gram-positive bacteria like C.maltaromaticum (MIC=50 uM), C.mobile (MIC=50 uM), C.divergens (MIC=50 uM) and C.funditum (MIC=25 uM) but also against C.glutamicum (MIC=12.5 uM). Has very little or no activity against Gram-negative bacteria.
Sequence:
MGAAKVLLVVLAVMVAVPNLAEGRSPPQCQYTNCAAVLCPAVYCANAYTPPCGCCDICPPQKYGGGYRPRG
The following text describes a protein:
Function:
Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope.
Sequence:
MPKGPKQQPPEPEWIGDGEGTSPADKVVKKGKKDKKTKKTFFEELAVEDKQAGEEEKLQKEKEQQQQQQQQKKKRDTRKGRRKKDVDDDSDERVLMERLKQLSVPASDEEDEVPAPIPRGRKKAKGGNVFEALIQDDSEEEEEEEENRVLKPAKPEKNRINKAVAEEPPGLRSKKGKEEKSKGKAKSKPAAADSEGEEEEEDTAKEKEPPQQGKDRDKKEAEQGSGEEKEEKEGDLKANDPYANLSKKEKKKLKKQMDYERQVESLKAANAAENDFSVSQAEVSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLRLLEEERRLQGQLEQGDDTAAEKLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDTQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEVLTRKQQKCRRKNQDEESQEPPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYEGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTNGEMRKNHRLKIGFFNQQYAEQLHMEETPTEYLQRSFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINDYKGAVIVVSHDARLITETNCQLWVVEEQGVSQIDGDFDDYKREVLEALGEVMVNRPRD
The following text describes a protein:
Function:
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MEGKKIKIAVFGSGSWGTALANVLCEKNYKVVLWGRDKEKVKKIEELRENIYYLPGYKLAPSLEITSNIDYATKDTDIAILSIPIQGLREFLKGNNTYLKRAGFFVNTGKGIEILTLKRPSEIIKEELDVDFNQIATLSGPSFAKEVMEKKPLAIVIASSDLNTAKYLQDILSLSFMRIYRSDDIVGVEIGGALKNVIAIAAGISDGLGFGYNAKASLITRGLVEINRMAILYGAHPFTILGLSGLGDLILTSTSALSRNWTVGKLIGEGLSLEEAMNKLNGMVAEGVYTAKSAYYISQKTNVYMPITQEVYKVLYENKPPHEALSSLLSKELKHEIDEDFQFNLL
The following text describes a protein:
Function:
Hydrolyzes intracellular trehalose to glucose. The disaccharide trehalose serves as a storage carbohydrate that is mobilized during nutrient stress and spore germination. Together with tps1, regulates the level of trehalose as a protectant for cell integrity during heat, osmotic and oxidative stresses.
Subcellular Localization:
Cytoplasm.
Sequence:
MPSKFSSKYVDTEAISNDDDNPFATAKSYYSKDTDLSTRVSAGRPRTLSTSMEASAAPTIPELKNLRRRGSLDEHKQPRKFLVDVDKTLNALLESEDTDRNMQITIEDTGPKVVSLGSASSGGYRLYELRGTYQLSNLLQELTLAKDYGRRYILLDERRLNENPVNRLSRLIKGTFWDALTRRIDASVLDVICRDTKDRSGSHVNRIYVPKAEQEMYEYYVRAAKERPYLNLQVEYLPEEITPEWVRDVNDKPGLLALAMEKYQDDEGNTHLRGVPFVVPGGRFNELYGWDSYFESLGLLVDDRVDLAKGMVENFIFEITYYGKILNANRTYYLLRSQPPFLTDMALRVYERIKNEEGSLDFLHRAFSATIKEYHTVWTATPRLDPKTGLSRYRPGGLGIPPETEASHFEHLLRPYMEKYHMTLEEFTHAYNYQQIHEPALDEYFVHDRAVRESGHDTTYRLEKVCADLATVDLNSLLYKYETDISHVILEYFDDKFVLPNGTIETSAIWDRRARARRAAMEKYLWSEADSMWYDYNTKLETKSTYESATAFWALWAGVATPRQAAKFVDVSLPKFEVAGGIVAGTKRSLGKVGLDNPSRQWDYPNGWSPQQILAWYGLIRYGYEEETRRLVYRWLYTITKSFVDFNGIVVEKYDLTRPVDPHRVEAEYGNQGVNIKGVAREGFGWVNASYEVGLTFCNSHMRRALGACTTPDVFFAGIKEESLPAFENLSIHKN
The following text describes a protein:
Function:
Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MGGGSPLLPETEKQARALETVLAQRLPSDTVKAFVAMRYWDPLTGETAKAVKAWKPDEVVLLPLYPQYSTTTTASSLKAWNKAYRKGPGRSTTVCCYPTADGFVQAHADLIRAEYVKAGSPKPARILFSAHGLPEKVITAGDPYQRQVEATAAAVVAKLGDILGEGVDWKISYQSRVGPLKWIGPPTDDEIKAASEAGLALIVTPIAFVSEHIETLVELDVEYRELAYEHGGSIYARVPALGVAPAFIDCLGTLVTQALADPSSLICEDDQPCPGAAA
The following text describes a protein:
Function:
Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (By similarity). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (By similarity). Can also act on valproyl-CoA, a metabolite of the valproic acid drug (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MERATVRLLRGGALLRRNFPSCLSSWKTPPHALNSSQSEAQLKATSNGPPLAPLQTFTDEEMMIKSAVKKFAQEQVAPFVSKMDEDSKMEKSVIQGLFQQGLMGIEIDTKYGGTGASFFSSVLVIEELAKVDASVALVCDIQNTLINRMIGKYGTEEQKATYLPKLATEKASSICISETGAGSDSFAMKTRADKKGDYYIINGSKMWISSAEIAGLFVVMANADFSAGYKGITCFLVDGDTEGLHVGKPENKLGIRASSTCPVTFENVKVPKTNILGQVGHGYKYAIGSLNEGRIGIAAQMLGVAQGCFDYTIPYIKERKQFGRRVFDFQGLQHQVAHMATQLEAARLLTYNAARLLEAGRPMIKEASMAKYHASELAGLITSKCIEWMGGVGYTKSYPVEKYFRDAKIGTIYEGTSNIQLNTIAKCISAEY
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MSATPDPRLKAETLTIRTLTGFDETVRVLGSKSYTNRYLAIASLSGQETVIDNALLSDDTVYFSRAIETFGHVTCDIDHATARIRVTPTGRPMRAPSEDIFVGGAGTPLRFLISMAGHADGTTIITGNARMQERPMGDLLKALPALGVDATAVRGNGSPPVRVVGGSFKGGATSISGAVSSQFTSSLIINALRAQTDTEITISDDLVSKPYVEMTLAGLAEMGVSVDRDGYRRFTVPSGQQARGGQVTVEPDASGMSYFLAAAAILQSRVVIPGIGAGSHQGDVHLVQALERMGCRTEVGDDSITVTGGPLRGIDIDMEAMPDVVPSLAIVAAYAEGTTRITNIASLRVKECDRIAAVTTELRKMGIDVEEHSDAMYITGGTPHGAVIDTYDDHRIAMTFAIGGLRTEGVVIKDPGCVAKSFPAFWQTLDTLHPDLESTK
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MDTDVEFSDASSDDDCSESDGDSLSDDEVVVPYAVLTEQEIGQRLSQEVAATAELFSVPADWALALLGHYRWNPLRLQDEWFADQDRVRDAVGLGDAAVGSVPGAGGEELMTCAVCTEGKPVEEMASAGCAHYYCHDCWRGYVAAALDDGARCLVLRCPDASCSRAVLRGMAERFATGAGRDAYARALARAYVEARHLWFKPCTAPGCGCAIEISRSGGDGDLACRCGNAFCWRCGGSPHWPASCAAVARWAREADEASADWILLNTKACPRMVCAKPCGYFFCWGCLGQTAVSRMGEHDMCGKDEEWTATGEEVRAEQALDRFLYYQDLWMAYLRRRRDAERELRRLRDERLPRAGGPAVRGYLEAVAAAWEQVAEGRRVLGNACAHGQSLRAAADPAARELFEYQRGEADEALERLRLRAIKWPQQEDLVGFGAELAKLTGVTRQCIENFAKAVEEGTPELCAPVSCGESGSG
The following text describes a protein:
Function:
Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. MlaB plays critical roles in both the assembly and activity of the complex. May act by modulating MlaF structure and stability.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNWDLQKNNDKITLFLFGELSRSTLLPMWQQRGVFLSASTLDKTIVEWNLSDLQHIDSAGFAALCDFLRECQKLNKTVRLVYPPKQLLTLADLFGLSDWIANFI
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MADDGVNETQRMDLNLYIGLPLMPHTGLELESVPVPLLREDTHVPIDTIGLSDSSRSVNATIQQPLSVDGSRSSVQMNSSEYSVDSPVTHRHRWRRWPRPYRRIDFHEMDSNALMVTLDEIRNSLDEDRDTIRDILPLERSTGTSETLKKVMEEAEVQDLGGKLNKQNNAAANFECNICLDLAREPVVTSCGHLFCWECLYQWLHVHSDSKECPVCKGEVTEANITPIYGRGSSTNNGSEKKCEEEGGLSLNVPPRPRGQRIESARPRLHRSFNRRLGEDFRYWHGLRHWSRAVGQEGILDDSLIDHIRRPERDLSGNDVAESLLEPQSQRDGVDGGSRGSALVRNGLDLWNHLSLTRIRRSGRLAALSARLADMESMLERLARINNMLISSGASPSVNPENSRDLGTQGTSLHEDQVSVSSTVAILQVENGVVDASNEPSSSGSSNLLRRRRAGASGSSDVDGEVYHARKRRRLN
The following text describes a protein:
Function:
Might be part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. This subunit may play a central role in organizing the structure.
Subcellular Localization:
Cytoplasm.
Sequence:
MNPFLNTAFKAARRAGQMMIRAAGNLDAVKTDSKAFNDFVSDVDRNSEIILVEALKEAYPHHKITCEESGSHGKAAAEYEWIIDPLDGTTNFLHGHPQYAISMALLHKGVLQEALVYAPERNDVYMASRGKGALLNDRRIRVSNRIELNRCLIGTGFPVVDQSMMDKYLAILKDFLAKTAGGRREGAASLDLCAVATGRFDGFFEFNLKPWDIAAGALIVQEAGGIVTDMSGEDGWLESGDIVAANPKVLAQMLKIISAHV
The following text describes a protein:
Function:
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.
Sequence:
MSQDDGAAEAEATVRVPMNIALVKYWGKRDDLLILPLNDSISLTVDRLTAETTIRMVPGVGKHTVEINGKSVELSSNKRYQTVFDEALRLQRKRKEAEASSADSNGNDPPPIFYHFHVTSTTNFPVAAGLASSAAGFAAIALAIQRILRLDDSQANRLARIGSGSACRSMYGGLVHWRKGEMDDGSDCLAVRTEAAANWEDLYCIILVFDDGRKKVGSSEGMRRSRETSQLLKHRIESIVPQRIQQIQEAYTSRNFEQLARVIMADSNQFHAVCMDSTPPIRYLNEASWQLIDTVEEFNIGGIRAAYTFDAGPNACVIVQKENASQFLKAVLQTIQVPSEDLQVIGKELAEQFDVPAEPTTKCSKLIMSPMGGGPQE
The following text describes a protein:
Function:
Spore specific glycosidase involved in spore wall assembly during sporulation. May be involved in copper import (By similarity).
Subcellular Localization:
Spore wall. Note=Spore wall envelope.
Sequence:
MSKRIIQLILLSAFARANYVEPFKSNPYIACSEASHCPKEWPCCSQYGQCGSGPLCISGCNPKFSHSPESCVPVPALLPQLEIVASDDKGVYLEMSGQPALVTKFQRKSSAQLLEVHHEEQQYGVSALEQDLNSRGLIHFPDYMITSKPKVAREMLEQYDFIHSGFISVDGKSESLILGMPKKTTGSLISSSKVFLYGRAAVTMKTSRGPGVITAIVFMSSTQDEIDYEFVGSELHTVQTNYYYQGELNHSRMRRHSLPSNSHEEYHIYEVDWDAERIHWMVDGEIVRTLYKRDTWDPVHKIYKYPQTPMMLQISLWPAGTPDAPQGTIEWAGGLIDWENAPDIKAHGQLAAQIQRVAITPYNNDFCPEIHESMGQWGAQNSEEEPFRVAYGYESNNGRFDPKKLKWYTDARLHLSSWHATGIKPTAAQRQQHHRRSLPHVEAPPITNTM
The following text describes a protein:
Function:
Involved in transport of phospholipids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MTKCRRRRLHLSNIYAFKGRKSNFQEDHSHIGGPGFSRVVYCNEPNSPAAERRNYVGNYVRSTKYTLASFIPKSLFEQFRRVANFYFLVTGVLSLTALSPYSPISALLPLTFVIAASMVKEAIEDWGRKKQDIEMNNRKVKVHDGNGIFRREGWRDLKVGNIVRVEKDEFFPADLLLLSSSYEDSICYVETMNLDGETNLKVKQGLEATSSALHEDSDFKELKAVVKCEDPNADLYTFVGTLHFEEQRLPLSITQLLLRDSKLRNTEYIYGVVVFTGHDTKVIQNSTDPPSKRSRIERKMDKIIYLMFGVVFLMSFIGSIVFGIETREDRVRNGGRTERWYLRPDNADIFFDPDRAPMAAVYHFFTAVMLYSYFIPISLYVSIEIVKVLQSLFINNDILMYYEENDKPAHARTSNLNEELGMVDTILSDKTGTLTCNSMEFIKCSIAGTAYGRGITEVERSMAMRSNGSSLVGDDLDVVVDQSGPKIKGFNFLDERVMKGNWVKQRDAAVLQKFFRLLAVCHTAIPETDEATGSVSYEAESPDEAAFVVAAREFGFEFFSRTQNGISFRELDLASGKTVERVYRLLNVLEFNSARKRMSVIVRDEDGRLLLLSKGADNVMFERLAKNGRKFEEKTREHVNEYADAGLRTLILAYREVDENEYIEFSKNFNEAKNSVTADRESLIDEITEQMERDLILLGATAVEDKLQNGVPDCIDKLAQAGIKIWVLTGDKMETAINIGFACSLLRQEMKQIIINLETPHIKALEKAGEKDAIEHASRESVVNQMEEGKALLTASSSASSHEAFALIIDGKSLTYALEDDFKKKFLDLATGCASVICCRSSPKQKALVTRLVKSGTGKTTLAIGDGANDVGMLQEADIGVGISGVEGMQAVMSSDIAIAQFRYLERLLLVHGHWCYSRISSMICYFFYKNITFGVTVFLYEAYTSFSAQPAYNDWFLSLFNVFFSSLPVIALGVFDQDVSARYCYKFPLLYQEGVQNLLFSWKRIIGWMFNGVFTALAIFFLCKESLKHQLYNPNGKTAGREILGGTMYTCVVWVVNLQMALAISYFTWLQHIVIWGSVAFWYIFLMIYGAITPSFSTDAYKVFIEALAPAPSYWLTTLFVMFFALIPFFVFKSVQMRFFPGYHQMIQWIRYEGHSNDPEFVEMVRQRSIRPTTVGFTARRAASVRRSGRFHDQLNKNFIAF
The following text describes a protein:
Function:
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. Antagonizes the action of wpl1 which stimulates cohesin dissociation from chromatin (By similarity). Cohesion ensures that chromosome partitioning is accurate in dividing cells and may play an important role in DNA repair (By similarity).
Miscellaneous:
MISCELLANEOUS: Named sororin after the Latin word 'soror', which means 'sister', because of its critical role in sister chromatid cohesion.
Subcellular Localization:
Nucleus.
Sequence:
MDSDDSFVKTAHVIETSTPENKKLSHRFKSVEIVPPSSSNDDPFGFSSTKGIRLSSINSNDLVNTLSKGFNETSNMSYNRILPSSPPTLEIGEIDYNEALQIRSADENQQSVPTVSIASPSTPELPPSSSPLLPPNGSESSSPIPLSLLSTSSLQQRKITPSNLSNTSKPMDSKQLERLIPVPHGHHLTRLRKKRRRDDDIDLSGLYETKSSSPPAIHSDEDPSYSDSIARSPVKSAFNLRKRRKGVKEKKILKTYHSQDKDTASDNDNNTGSSDEENDNLKELTPGKKEYLKSIKKYFQDVDDYQLHVVNEG
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate-mannose synthase complex.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQRIHKVILYYVSLTILYRVTYLFDLEEPWSTLRPYTPYLFILAFGSYLGITLLYNVATTNDKPEAYVDLVKDIKEAQDALRSKGMTIED
The following text describes a protein:
Function:
Required for vacuolar protein sorting. Component of the retromer-mediated endosome-to-Golgi retrograde pathway. Required for efficient cargo export from the endosome, promoting Vps1-mediated fission of retromer-coated tubules that bud from the endosome.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes throughout the endosomal system binding to phosphatidylinositol 3-phosphate (PtdIns3P). Enriched on retromer SNX-BAR-decorated endosomes.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate, which is necessary for peripheral membrane localization.
Sequence:
MGDNVFLEPDPWASSSNWGSPVKPLNYKTAIGNSSIPLQYRNYWDVFQANNVLLFPEEESYSDIFHVPQDVMKEFFTLIESSSNQPLRQIQFFVLLALVACYQLGVPSTLEQIFKQRNVLPILQRFNPELFNRSSDNETPLFPNNSPPASTTALNLSSNIVPSINESKILEQEDDDVSNKSLPHAQQSIIRSFPDIQKQPKGFFSYPSSTVSSIAPSTLEAGNLHSQQPPKFSVDSSVDDNAITPRKPFSKIPNRLSPSTQPLLSNSRHSSFRLASSSTSFPASLEMNVDIDLEPSGYFFYRHNNYIISDSSNTREVLRRYSDFFWLHSYLMKKYPFRRVPLIPLKKFHFAKRNASTQNSFLEHRRQELSDFVNDLSHHPIFSNDEVVRVFFTEPNVFKNWRRENQKRIDQEIEQFLVVPQSQVPDASETVKERLLKLNMSTTTAINNQLNIFRIFEKMIFTLQHFHEDFLRLQNSFNCLLDSGLYHQVFTSTFAQNESKIMSMASGHFYNIDSLLHQQNDAVKHTFLLGLSKEIKILISLRLLIERISEVFSTDLTKVRHTISNDENLLRETANSDESGRNRTFLNRSSKKRAENSLKSKKELYLKNLNQRYQIAHELEQELSYLQDYVFSLGNPYVEYCKQHVKLEEESLKIWHTLESDFSRLET
The following text describes a protein:
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
Sequence:
MCLVTQHYCPLLILATDFGSVDPSFDRLKVFCVRTSSRRVVSSKMDFEQGAFVHRSGVANARNFYAWNYRTYLLAFFRFSPSRLIAAVCMYILKANEQTRGEELDDTTDMIDTNFKSYSVLHNRSALLAKLLSKKASGKGVVLGEEYELVHQTIFTDPDDRSGWFYHLWLLDQTVKTHLHHLVSSWPPRSLNVALSRTGCLDDHTLSHLVVSFRIQENYSSFFTLINLFKESTHLQ
The following text describes a protein:
Function:
Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. TOD6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif.
Miscellaneous:
MISCELLANEOUS: Present with 830 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTLPKLSSVSVSSGHVSANSHGFSILSKHPHPNNLVHSHSLSHTNAKSHLPISSTSTKENSTNKEEAESLKKNNPSSWDPSDDIKLRHLKEIKNLGWKEIAHHFPNRTPNACQFRWRRLKSGNLKSNKTAVIDINKLFGVYATGDATPSAGTPSAEEAVKEEAVEDEDITAGSSAIEDSPPDFKPLVKPKYMDRKLITQRSTSTFSDHEPQHTKPRKLFVKPRSFSHSITTNTPNVKTAQQTNLSLYNTTSAKTNKAVNSNDYENIGLVPKIIIRSRRNSFIPSTQIPHSTTKTRKNSHSVISSRRSSFNMMHSRRSSFNSHAPTEPISRRASLVVSPYMSPRRLSTSQSVHYHPQHQYYLNPIASPNCKTDHANDKITHTRTFLDMQKFANKHPWSREDDEVLLNNTKDKQNHLSPLEISIVLPNNRSELEIQQRMDYLKRKGRVSGFHTNEGCKDEEEEDDIDPLHKENGINTPSQQSQNYGMLEAKHDNPKSSELSSMTSANDIRNEQDELPGINSIFKNIF
The following text describes a protein:
Function:
May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1.
Subcellular Localization:
Cytoplasm.
Sequence:
MSITRPTGSYARQMLDPGGWVEADEDTFYDRAQEYSQVLQRVTDVLDTCRQQKGHVFEGGLWSGGAANAANGALGANINQLMTLQDYLATVITWHRHIAGLIEQAKSDIGNNVDGAQREIDILENDPSLDADERHTAINSLVTATHGANVSLVAETAERVLESKNWKPPKNALEDLLQQKSPPPPDVPTLVVPSPGTPGTPGTPITPGTPITPGTPITPIPGAPVTPITPTPGTPVTPVTPGKPVTPVTPVKPGTPGEPTPITPVTPPVAPATPATPATPVTPAPAPHPQPAPAPAPSPGPQPVTPATPGPSGPATPGTPGGEPAPHVKPAALAEQPGVPGQHAGGGTQSGPAHADESAASVTPAAASGVPGARAAAAAPSGTAVGAGARSSVGTAAASGAGSHAATGRAPVATSDKAAAPSTRAASARTAPPARPPSTDHIDKPDRSESADDGTPVSMIPVSAARAARDAATAAASARQRGRGDALRLARRIAAALNASDNNAGDYGFFWITAVTTDGSIVVANSYGLAYIPDGMELPNKVYLASADHAIPVDEIARCATYPVLAVQAWAAFHDMTLRAVIGTAEQLASSDPGVAKIVLEPDDIPESGKMTGRSRLEVVDPSAAAQLADTTDQRLLDLLPPAPVDVNPPGDERHMLWFELMKPMTSTATGREAAHLRAFRAYAAHSQEIALHQAHTATDAAVQRVAVADWLYWQYVTGLLDRALAAAC
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Subcellular Localization:
Cytoplasm. Mitochondrion matrix.
Sequence:
MEPKSMEAASVVLSQRCLARLPEVLRQAATRCSRLYVAVHPELPLQSTLDSIYARASEHAPQLDVRVMLKSALPHGVSPLRAEDGSLPPRVCLGGTFDRLHNGHKVLLSRAALISSEAIVCGVTDGDMIIKKTLWEMIEPVERRMRAVEEFVKDVTDVSCLLYPITDPFGPSITMADLNAIVVSDETYKGGQAVNSKRAERGMSELVIEKIGLIEADDTLLKETKLSSSSRRKEALGTLLKPVNTQTRFRPYTIGLTGGIASGKTKVAEDLRSMGYTVLDCDKIAHGTYAAGSDLVKQIAVAFPSVVNEKEEVDRRALGNIVFNDTAKRLQLNALVWPAVLRAVQTELEKMPSDSVVFVEAAALVEAGWPKDLHETWTVFCARAEELRRVQQRDKLDEQQAEARVSSQISNRERLAASNVAICSDWEREVTREQVKKAVELLEKRRK
The following text describes a protein:
Function:
Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Sperm acrosomal crescent and flagellar principal piece.
Domain:
The IQ motif is involved in calmodulin binding.
Sequence:
MDPTCSSECIYNLIPSDLKEPPQPPRYISIFKATVKDDMQKAKTAMKTMGPAKVEVPSPKDFLKKHSKEKTLPPKKNFDRNVPKKPAVPLKTDHPVMGIQSGKNFINTNAADIIMGVAKKPKPIYVDKRTGDKHDLEPSGLVPKYINKKDYGVTPEYICKRNEEIKKAQEDYDRYIQENLKKAAMKRLSDEEREAVLQGLKKNWEEVHKEFQSLSVFIDSIPKKIRKQRLEEEMKQLEHDIGIIEKHKIIYIANNA
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Sequence:
MRLRHKPYAMDRINEYSHIVIGNPEERAGSWKEVFGNEQPIHIEVGTGRGRFMYDMAKANPHINYIGIEKFTSVVVDALDKLIEEELPNLKLINKDAEDLTVFFAKGEIDRVYLNFSDPWPKKRHTKRRLTYKTFLRNYEEVLVEGGEIHFKTDNQGLFEYSLMSMAEYGMLLTYLSLDLHNSDFEGNIMTEYEEKFSSKGHRIYRVEAKYRTEPMQ
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MDNNAQPQGQLQLQSQMDIDIHEPFTTAEHIQQLSNIDNDIVSLLELTSNALRCLASPPPTSSDTQNQTEAEQQKQQQEEQDQEDATTRFTQIQSTFLSTLDRVDKQLRRQIYAMEEAGIINLRSSSSNSNPNNPDDDGTGGPGEPSASNKPGGYAAASAPKNPGELTRPAKIETHRGAKWVRPVVARLDPDGVGRYGNLDVGRMNMAIDTVERDMERELWLRAREHAERVVKEKGVPAAGVGPLGAGGVIKKEEEGADRMDED
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MAEESSSSCSAQATKKISLKTADGHLFEVEEPVAMEFEIVKSFFDENDDASEDTVVPLPNVSAAPLSYIIEFCRAHVEFRKKRSPKQEVKTFNEEFGKSKSNDELKEMILVANYLNIKDMLDYLTETVANRIKNKSVEYVRKFFGIENDFTPEEEEAARKEYEWAFEGVDPDDDDV
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of UMP to UDP.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKRIVIKLSGRVFAMDNVKLLKDWAEFLVKISKVCQPIIIAGGGNIARHYINHARSSGADESTLDELGIEISRLNAKLLIYALKNKAYSHPPTTLQEVRHAVDDGLIVVAGGLHPGQSTNGTAALIAEKVKAEQFLNATDVDGVYDMDPNKFKKAKKFKRIELKNLKNMLVHEDSVAGGYDLMDIVALKIIERSKIKTRILKASPKIIEKAIKGGNLGTEIIIPTK
The following text describes a protein:
Function:
Possible regulatory or functional link with the histocompatibility cluster.
Sequence:
MPARRKPFSHKQKKEQLKEKRQANIAKEHDATSREQKKLPSTKAKQDPSHFFLRFINDSDAVVQKNKEAAYVPFNTTGDSFSLDQHVYLLPSCCADIPRRPEGVLKMSKDELLQAETAVFEAFFKGISPDLDVIATEYCVFECNENVYRQVWRVTERSNLMCIVVDARFPLAHLPVSILRYAKICVRPVIIVLNKIDLAEKDSVDAWVAFLNKYVGAVLEEVNGQKQFAIMTCNSMLLKENKEEHKHFMEAFVSASRALSGISTPKRITIGFFGQPSVGKSSLINGIYGKKVVSVKLTPGHTKHLQTHYLPLSGVVEGETDRSFVLCDCPGLVFAVKGSPRPLQVITGVFPLARTREFLTPLRLLVECVPGFKEDIVERLNLDSLYTRYPELNQKKPDSPGEILELYAYMWSYFSKGLTPNINRAGMELFKLIVNGSIAYTVYPSQDLDKNLNSVLENLPSICPAIYVNAEEARDESESDTEYEEDTSGVEEL
The following text describes a protein:
Function:
Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. Required for localization of ctn-1 near dense bodies in muscle cells.
Subcellular Localization:
Cytoplasm.
Domain:
The coiled-coil domain mediates the specific interaction with dys-1 and ctn-1.
Sequence:
MLWSNGGGGPREPSSAPSPDHHRAMHSVPPIVASEMQQLIDEMRLQDFDSIRFATYRAACKLRFIQQKTKVHLVDIWNMIEAFRENGLNALPLHTVIKTSRAELLLTTVFHNLNKRLVASQHVDTDVSISLLLAFLLGAYDKQNTGRLTVFSIKVALATLCAGKLVDKLRYIFSQIADSNGLMDHIKFTDFLQQILSLTTAVFEAPTFGFSENAVNQCFHKDEKVSLNVFLDTFLSDPCPPCIMWLPLLHRMASVSNVYHPVVCDACQVRSFTGFRYKCQRCANYQLCQSCFWRGRTSQNHSNEHEMKEYSSYKSPTKQLVHSIHKSLQCIPATSTVGDANIDIFNAKIGGPVSSKPARPLNLNNIVPATPTTIRRQHAATSSADWPTSPVLLPGQASHGGVIDDEHKLIARYAAKLSGRADYPLSNGRSMNSSMVGDERTLIAQLEEENSMMVREMARLESQTTSDDGLAGLRDRKMELEEKMFEMQQRRRELMMQLEHLMAQLNTGPQPSGGVSSASLSQLPFTASDQQLTGVNSTVANAFRAGSLPATSLQGDLLHAADQITTNMSDLVRQLDLAQSDENGVTINGF
The following text describes a protein:
Function:
Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGKKRSREEAQKEVVQNDPTVDKMDEDSDSSDSDEDMDIINVDFELFNYDKDIDFHGVKTLLRQLFDADAQLFDLSGLSDMIIEQNTIGSTCKVDDKANDAYAFLTVLNAWEHREKKPVAQLIEYLSDKAVKAGDSSLSVLPELFTSGKAQVGIVLSERLINMPAEVIPPMWNMMIEEIQDAVDDKEPYEFTHYLVVSRAYVEVESSLDQEEQKRKRLRDEKGLQYFHPEDEEMRKHAVGAGTYTFTKEGDSADSKRAFQELGVKSQGFMMLIEAGRFKQAVKAIGDCIGAAN
The following text describes a protein:
Function:
Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator/promoter regulatory region of this operon. Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex.
Sequence:
MTQNPAQVSLRPNNRLSDMQAIMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNILVLQVFRKDDYAVKYAVEPLLDGDGPLGDLSVRLKLIYGLGVLSRTEYEDAELLMALREELNHDGNEYAFTDDEILGPFGELHCVMALPPPPHFDTSDAALYAMQIQRYQQAVRSTMVLSLTELISKISLKKAFQK