lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters. It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes to the distal part of the subdistal appendages of the mother centriole in interphase. Also found at the proximal ends of centrioles and along microtubules. The centrosomal localization is dependent on centrioles. Dissociates from centrosomes during M-phase without proteolytic degradation and reassembles at the centrosomes during late telophase and early G1 phase. Dissociation and reassembly is regulated by phosphorylation.
Sequence:
MASSETEIRWAEPGLGKGPQRRRWAWAEDKRDVDRSSSQSWEEERLFPNATSPELLEDFRLAQQHLPPLEWDPHPQPDGHQDSESGETSGEEAEAEDVDSPASSHEPLAWLPQQGRQLDMTEEEPDGTLGSLEVEEAGESSSRLGYEAGLSLEGHGNTSPMALGHGQARGWVASGEQASGDKLSEHSEVNPSVELSPARSWSSGTVSLDHPSDSLDSTWEGETDGPQPTALAETLPEGPSHHLLSPDGRTGGSVARATPMEFQDSSAPPAQSPQHATDRWRRETTRFFCPQPKEHIWKQTKTSPKPLPSRFIGSISPLNPQPRPTRQGRPLPRQGATLAGRSSSNAPKYGRGQLNYPLPDFSKVGPRVRFPKDESYRPPKSRSHNRKPQAPARPLIFKSPAEIVQEVLLSSGEAALAKDTPPAHPITRVPQEFQTPEQATELVHQLQEDYHRLLTKYAEAENTIDQLRLGAKVNLFSDPPQPNHSIHTGMVPQGTKVLSFTIPQPRSAEWWPGPAEDPQASAASGWPSARGDLSPSSLTSMPTLGWLPENRDISEDQSSAEQTQALASQASQFLAKVESFERLIQAGRLMPQDQVKGFQRLKAAHAALEEEYLKACREQHPAQPLAGSKGTPGRFDPRRELEAEIYRLGSCLEELKEHIDQTQQEPEPPGSDSALDSTPALPCLHQPTHLPAPSGQAPMPAIKTSCPEPATTTAAASTGPCPLHVNVEVSSGNSEVEDRPQDPLARLRHKELQMEQVYHGLMERYLSVKSLPEAMRMEEEEEGEEEEEEEGGGDSLEVDGVAATPGKAEATRVLPRQCPVQAEKSHGAPLEEATEKMVSMKPPGFQASLARDGHMSGLGKAEAAPPGPGVPPHPPGTKSAASHQSSMTSLEGSGISERLPQKPLHRGGGPHLEETWMASPETDSGFVGSETSRVSPLTQTPEHRLSHISTAGTLAQPFAASVPRDGASYPKARGSLIPRRATEPSTPRSQAQRYLSSPSGPLRQRAPNFSLERTLAAEMAVPGSEFEGHKRISEQPLPNKTISPPPAPAPAAAPLPCGPTETIPSFLLTRAGRDQAICELQEEVSRLRLRLEDSLHQPLQGSPTRPASAFDRPARTRGRPADSPATWGSHYGSKSTERLPGEPRGEEQIVPPGRQRARSSSVPREVLRLSLSSESELPSLPLFSEKSKTTKDSPQAARDGKRGVGSAGWPDRVTFRGQYTGHEYHVLSPKAVPKGNGTVSCPHCRPIRTQDAGGAVTGDPLGPPPADTLQCPLCGQVGSPPEADGPGSATSGAEKATTRRKASSTPSPKQRSKQAGSSPRPPPGLWYLATAPPAPAPPAFAYISSVPIMPYPPAAVYYAPAGPTSAQPAAKWPPTASPPPARRHRHSIQLDLGDLEELNKALSRAVQAAESVRSTTRQMRSSLSADLRQAHSLRGSCLF
The following text describes a protein:
Function:
Translocates protons across the thylakoid membrane and transfers electrons from photosystem II to photosystem I. It receives electrons from the Rieske iron-sulfur protein and passes them to plastocyanin.
Miscellaneous:
MISCELLANEOUS: This polypeptide is nuclear encoded in Euglena gracilis, but is chloroplast encoded in other plant species.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MASLQTPVMVGTVVGCVAGVVGFLAMSSNAATSLSVAPASTSTQIIANPSVIAPQYQGSVTSEDVAMEASQTDFAEVAEISSPVQVQSWSMIFSAMLAVPLAAAAMFFMKKSTTEERRPLVSIDDLLSVGKKAVVASAVVGAAAGSANAYPIFAQQAYGNPREATGRIVCANCHLASKPTEIEVPQAVLPDQVFEAVTKVPFSGPSGFFNVVDPSTVVGSVTFAGTQPVGFIQESGVPVSQALVDIATPGTPDTVFKATIKVPYDESLKQVAGNGRAAPLNVGAVLILPEGFRLAPPERIPEKMKEEINGLQFIQYSKDTPNILVVGPVPGKKYAEMTVALLSPDPRVDKKAEFGTLPIYVGGNRGRGQLYPTGEKSNNNIYNVEHSGKIADIQLNEKKRIYTVAVQQKDGEIINEDLPAGAELIVKVGDVVEAGQAISTNPNVGGFGQAESEIVLQNPGRVQAFLFFSFTVLATQTLLVVKKKQYEQVQLSEMNF
The following text describes a protein:
Function:
Component of the HIR complex, which functions as a histone chaperone that cooperates with cia1/asf1 to promote replication-independent chromatin assembly.
Subcellular Localization:
Nucleus.
Sequence:
MSLLSGDQRIICLEIPLQGKENVHINFAKEVEKLYGPSVQENSKKNDLSDSADSEGESTHVDEQQAANGAADGTQTIKKKKRKRRYADEYYDRTDPFIDDAELYIEEKAAATKDGFFVFSGPLVAEGDTVKIERSKKTKKKKKTSLSNATHPAPAVSAVVASADASFDDSRDIESEDEQPLRTLSIEMAAKNALKEAKRENAKVPKDVSKKEAKTTKSKEKATKKTSSSVPKQSTGENTKKAVKLETPLTSTPPIPPLSEPKHSPATVNEHISPPSALTNPSTEELKPSTSLPIDQGNASVVSKPTQQVSIVLSQNASLPVDEHQAEPEKSIPTSSIP
The following text describes a protein:
Function:
Protein kinase of the mitotic exit network (MEN) essential for late nuclear division in the mitotic cycle. Promotes mitotic exit by phosphorylating DBF2 and directly switching on DBF2 kinase activity. Involved in the localization of DBF2 and DBF20 to the neck which is necessary to undergo cytokinesis. Plays a role in segregation of chromosomes during recovery from spindle checkpoint activation. Required for spindle pole localization of CDK1 and inactivation of CDC2 kinase activity at the end of mitosis. Required for spindle disassembly after meiosis II and plays a role in spore morphogenesis.
Miscellaneous:
MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle pole. Bud neck. Note=Localizes to the spindle pole bodies at late anaphase and translocates to the cytoplasm upon DNA replication stress. Localization to SPBs depends on CDC5 and TEM1 and is inhibited by BUB2. Accumulates at the daughter SPB after anaphase onset when the daughter SPB begins to penetrate the bud neck. Not found in the mother SPD during early anaphase. As anaphase proceeds, continues to accumulate on the daughter SPB and also localizes to the mother SPB. At the end of telophase, a portion of CDC15 localizes at the mother-bud neck.
Domain:
The region between residues 360 and 702 is essential for function and is required for self-association and for binding to spindle pole bodies; The region between residues 751 and 974 is an auto-inhibitory domain which inhibits MEN signaling.
Sequence:
MNSMADTDRVNLTPIQRASEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWINSTENVKVDKLNKFKEDFTDADYHWDADFQEEKLNISPSKFSLAAAPAAWAENNQELDLMPPTESQLLSQLKSSSKPLTDLHVLFSVCSLENIADTIIECLSRTTVDKRLITAFGSIFVYDTQHNHSRLRLKFIAMGGIPLIIKFEHLAKEFVIDYPQTLIECGIMYPPNFASLKTPKYILELVYRFYDLTSTAFWCRWCFKHLDISLLLNNIHERRAQSILLKLSSYAPWSFEKILPSLIDSKLKKKILISPQITYVVFKSINYMITTNDDKIHKSAIPSSSSLPLSSSPTRNSPVNSVQSPSRSPVHSLMATRPSSPMRHKSISNFPHLTISSKSRLLIELPEGFFTWLTSFFVDMAQIKDLSVLKYFTKLCYLTVHINSTFLNDLLDNDAFFAFIRNIDTIIPFIDDAKTAAFIWKQITAICVEMSLDMDQMSASLFSTAMNFIRKKNNTSISGLEIILNCLHFTLRNVNDDVAPTVGSSESHSVFLIKVNNDAAIELPIDQLVDLFYALNDDDVNLSKLISIFTKICSLPGFENLTINIIFHPNFYEKIVSFFDTYFNSLLIQIDLLKFIKLIFSKSLLKLYDYTGQPDPIKQTEPNRRNKATVFKLRAILVQITEFLNNNWNKDVPKRNSNQVGGDSVLICQLCEDIRSLSKKGSLQKVSSVTAAIGSSPTKDERSNLRSSKDKSDGFSVPITTFQT
The following text describes a protein:
Function:
Involved in biosynthesis of mugineic acid family phytosiderophores.
Sequence:
MATKQSNGNGAFAAANGNGKSNGAAHHAMNGKSNGAAAPEPEAVDWKFARAKEGVLAISGAKMSIRAVRYKISASVREDGPRPVLPLAHGDPSVFPAFRTAIEAEDAVAAALRTGELNCYPAGVGLPAARRAVAEHLSQSLPYKLSQDDIFLTAGGTQAIEAIIPVLAQPGTNILLPKPGYPNYEARAAFNNLEVRHFNLLPEKGWEIDVDSLESIADKNTTAMVIINPNNPCGSVYSFEHLTKVAEVARKLGILVIADEVYGKLVLGSAPFIPMGVFGHIAPVLTIGSLSKSWIVPGWRLGWIAVCDPKKVLQETKIATSITNFLNVSTDPATFIQGALPQILENTKEEFFQGIIALLTESSEICHREIKENKFITCPHKPEGSMFVMVKLMLQLLEDIDDDIDFCCKLAKEESVILCPGSVLGMENWVRITFAIVPSSLLDGLQRIKSFCQRHKNKNLINEVNCKLD
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in autophagy. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome.
Sequence:
MAQASGRSGRVVGDYLVGRQIGSGSFSVVWHARHRVHGTEVAIKEIVTNRLNKKLQESLMSEIFILKRINHPNIIRLHDIIKVPGRILIVLEYCEGGDLSMYIQRHGKVPEAIAKHFMQQLAAGLQILRDNNLIHRDLKPQNLLLSTSDNNAVLKIADFGFARSLQPRGLAETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQLVTGKTPYTGNNQIQLLQNIVKSAELQFPFDNKDLSAGCKDLCRKLLCCNPVERLTFEEFFNHPFLSQRKKDELLRSSRSVDGFPFSGSNPARNADDNSQEDCLPFLLDDDSSCPEGSPSVSKRMSPMKSTYGFSLDSRIGGRDATSNVFNNVDLTSRYSSARQNLENASFRPGINKASDENLNEPPKSIDQRSVNIRSRVVDSLDLIDQDYVLVSGPPLNVSSSTASTYKPGNAPYKSEGPSQAFTYTNTRLSIPVPIIDTANNNPCRFGSLEIPASAPGTSEGSLDMGDALEQPSTHCMTRIKSLQHCASAIMELVVEKIKAGRQLEAFSIQLVILAIWKQVLHICHTQAASAIEGSPSQESSRLRRSSSKKHGNPDTEDCPDVGPENMSTQIEAEFLQEVERAEELAKAIETGSTEMPDAMEMIFQSALSLGRHGGVDELMGNMENAALLYSRAGCLLVFLLVEAPSLILNPPFSLTNSDRYRLRSYIDILNNRQDHSRSQRMALLKCEDQRWSP
The following text describes a protein:
Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MERCSRDGNLIPKCMRWSKANIPDSQNKTQSKHSQGYESWRELAKVLADPNVPGGDLSLPFYYSQKVGHQNQEHQRSGRNKSNYAAMNNPVPWMPEFQGQANLHVFEDWCGSSTEQLRRNLHFPLYPHTRTVLKKLAVSPKWTNYGLRIFGYLHPFTDGEFQFAIAADDNAEFWLSSDEKTSGLQLLASVGKTGKEWTAPGEFGKFWSQQSKVVRLSAAGRYYFEVLHKQDDKGTDHVEVAWKLNDPDAKFKVIDSQYLSLFANETLLKMDEVGHIPQTLASHKRRATDSTGSKAHPADMLKPDPRDTLYKVPLLSKSRLRRALPDCPYKPSYLVNGFPLQRYQGLQFIHLSFVYPNDYSRLSHMEKENKCFYQENPYYLERFGFYKYIKMDRRKQSLDSEEKTEQPGFQEGNLDDLQYGEQDVESTVSPAHPNMQRAEPADTAPGTVVGSHRVYEDYSLREHRRLLSVGDIGEVTQRRRTKKSGVKTALLAPANQSLSRAGPERNPATKRPHLKAGVKDNSRSPPQHARAAQGRAPAKKENPPSRSRSQREQPLSSPRDSGVRIPKGNRGDLSVMEDGLQPAGTEQARRADAASSKTSRHLVDTAGPSKDPPRLEQWLNQVEAYVAEQKRAAGGDAGKEETQVASLAKGKSRPDKMAAEEEEEEVDGEPEEEDEEGFDYVPVFDQLVNWEQTFSASNLDFHVLRTDWIDLKCNTSGNLLLKEREALEVTRVFLKKLNQRIKGRFQLQRIVNVEKRQDRMRGSRYLLELELLEQGERLVRFSEYIFARGWQGVGGDEQEERNMRNLAWGRRRHLMAVAKEPELCWPQGFSWNHRAVVHFVVPVKNQARWVLQFISDMEELFRVTKDPYFNVIITDYSSDDMNVETALKRSSLRSYRYLKLMGNFERSAGLQAGIDLVTDPHSIIFLCDLHIHFPPGIIDSIRKHCVEGKMAFAPMVMRLHCGMSPQSPDGYWEVNGFGLLGIYKSDLDKIGGMNTKEFRDRWGGEDWELLDRILQAGLEVERLSLRNFFHWFHSKRGMWNRRQLKTL
The following text describes a protein:
Function:
NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome.
Sequence:
MMENYEEIRLGHIRSKDLGNQVPDTTQFYPPTKFDFGAEILASTSTEAEAEAEATATTTEPATSELAGKANGEIKTKTLAAREEQEIGANLEHKTKNPTKSMGEDEDDEEEEEEDDEEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIKSNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAEAAAIERIKTDILVELNETTALSCDRLGLEGPQTTVESYRHLSIDSSKDSGIEQCDNEATPSYVRPSNLVQETKTVAPSLTPIPQQRGKRQTAAERLQPGTFYSHTNNYSYVFPGAQVFWDNDYSDDDDEEEERSHNRHSDLFGNVGHNYKDDDEDACDLNAVPLSPLLPPSLEAHIVTDIVNGSNEPLPNSSPGQKRTACIIEQQPTPAIETEIPPLKKRRPSEENKQQTQIERSEESPPPGQLAAV
The following text describes a protein:
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
PYFQTYIVVNDQGSIFRFSKAESLFLFGQESRLRNAAINLFIKPMFSNFIMLVILFNCACMVLENPPHWVDDYLEYVFTAIYIAEATVKITARGFVLHSFSYLRDPWNWLDFIVIVSALATEILKAIVRSTMLGQIAVLRTFRVLRALKTMSVVPGLRGIVKALLRSIHALKDAVALTVFCVSVFALIGYQLFHGTLRQKFFDNGERNNNKITRIMELGAKIQSLKHEISYIYSITYSISMFSDMCPLGYGCYEAGGNPDYGYTSFDHFFLAFLTSFRLVALDSWSRLYYLTLHTIGKTYAIFYIVVVLLGSYYLVNLILAVVYMAYEEQQAVVEEEELEAKEREAEKREQERAYTIDATSSDTCTCSDDSSMYQHGDMQRPKRRRSLSKSRRRRYRRKSPVNLKSLEENKKDKHEDKPSIRLIVTEIESEAESGHRMLKNKQENHHEKNANFLSVNEALRRGRMSSLSSETSSCCCNSKFSSTEFSFRRLSDSSSMWGDNESEQGLYFPERTQERRQRQLCELAHYPIIQRFKLKLILSSTIIGMGPAEYFQTNNNLLSPVNPSPVKTTGDPAADDINIDEDQTIAVISEDDISPTSRRARWKLKNKKMTDRYQKFSRAFVNLFCKWRCCPAGWSKIQRKVRRIVLNPFTDLLITLCIALNTLFMSLEQHPMEAWFAKILDNANVFFTIVFTVEMLMKIIGLSPYTYFNERWNVFDAVVVLFSLLELLLNSTQGLSVFRAFRLMRILKLAKQWPTLNKLLRIIGKTLGQLWHLTLVLFLVLFIFAVVGMQLLRESYISHYLEHNQGKLPRWNFIDFPHSFMVVFRIQCGEWVENMFTCLNVAPPGICIPLFILVYIIGNLVILNLFLALLLNSFSGDVLQQTEPSKSRNDSVCAIVQESNDLLNNPNKETCKEKRSRSVTPEGRCSSRVSRRRNSMTSRASESSSIPLSPTSSSHRRRKASVSARDRYRGIRSSVGEGSGGEGIKENGREDKLTNKNHVRRVSRRFGILAMQNLNQVQDEDKTESVEEENEVNETENEKTPNSRDGLKDCLIQHTINSPTFPFLKFQSKLQPCFSCWTREPLSGPWFEMREFMHKIIIHRYFENIVIFCILLSTVTLAMEDIHIDKRPAMKKVVHIIDIFCCIFFTVEMLMKWIGKGLRSYFTNPWCCLDFFIVLVSLVNIFMASNQRADFSALRALRTFRALRPLRALSRFQGMKIVVDALIRAVPSITHVFFICMIFWLIFSILGVNIFGGRFGRCVSLMTGDIMLLPIIRNRTECELCANMMNTTLINWQIPSVNFDSAPRGLLALLQIATFTGWIEIMGSAIDITGIESQPRYENSFYNYLYFCVFIIFGAFFSLNLFIGVIIDNFNQQKIKTKGGEDGVFLTDEQRRYYNAMKRMASKTPKKPIPRPNSRFANKIYDIVTDRKFEIAVMGLIMLNLVVMAIEHHDMSPEMYKLLQNFNLGFICVFLLEAILKLIGLRLYYFTVPWNVFDILVVVVSLIASGLHDVMTQYFVQPTIFRIIRLFRVTRILRLIREAKGIRTLLFALMMSLPALFNIGSLLFLLMFIYAIIGMSQFPYIQKVAGVDDLLNFETFPNAFLVLFQISTSEGWDTFIDPVLRDREPYCDESPADGSPSNCGNATVGVIYFVTYVMITFLIVVNMYIAIILENFEVATRESAEPLTADDFEQFFEVWQRFDDRLTQFVTYEQLKLLLHQLDFPLRVALPNTAFISQAHMKVTLDGRIHCLEVIITLIKKVLGDSPELNNLKDSMLQSFKLKCPAKESLEDQETIDSEEFTVQLRAVIIIQRAYREYR
The following text describes a protein:
Function:
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
Subcellular Localization:
Cell projection, podosome. Cytoplasm.
Sequence:
MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPRQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADTNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYASQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKIKDDLPARKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGPEAPIAKKEISLPILCNASNGSALGVPERTVSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPAGTGENQDSPLKLKYEEPEYDIPAFGFDSEPELSEEPAEDSGSGDRRPAQPHRPSPASSLQRARFKVGGSAEDVALEEETIYENEGFRPCAEDSLSARRSSRDSDSPGGSPLSLARKNSPKSGSPTSSSLLKLKAEKNAQAELGKNHSSASFSSSITINTTCSSSSSSSSSSLSKNSGDLKPRSASDAGIRGTPKVGVKKDPDLKAGLTSCARAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSRSEDSELPPQTAFEGPSEGSRRGSADLITLPASTPPCPTKKGREGQATSYMTCSAYQKVQDSEISFPAGVEVQVLEKLESGWWYVRFGELEGWAPSHYLVLSEDEPPDHPGKEPDTVAAKSKQNEGKSDSLEKIEKRVQALNTVNQNKRATPPIPSKPPGAFVKTSGAGAVKMRNGVRQVAVRPQSVFVSPPPKDSNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDPPLLPTQRNGIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN
The following text describes a protein:
Function:
Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.
Subcellular Localization:
Secreted.
Sequence:
MLYLLTIFSLLLPALAINARSNSNVAVYWGQNSGGSQQRLSYYCDSDAVDIVILSFMHQFPSPIQLNFANACEGTYTANGILQCQTIAEDIKYCQNKGKTILLSLGGAAGSYGFSDDATAKQFAHTLWDLFGNSKNLATNDRPFYDAVLDGFDFDIENNWSTGYPALATELRTLFQKDTSKNYYLGAAPQCPYPDASVGPLLKQSEIDFVFIQFYNNYCNLGSSSFNWDTWLNYAETDSPNKNIKLFVGVPASSRAAGSGYNDPSAVSQYLTSDILNSKYFGGISMWDVSAGWSNTNSNGNFVENMKAIVKKASPGEETTSSSTTTTTTTTSTTISSSSSSSKTSKTSTTSTTSSSISSTTSSTTSSTSSSSTSSSTSSTTSSSTTSSQISTTSTAPTSSTSLSSSTISTSASTSDTTSVTSSETTPVVTPSSLSSAITIPGDSTTTGISKSSSTKPATSTTSALSSSTTTVATIPDDKEIINTPTDTETTSKPPAIITESDATTITQNLTPSTTTKNVKTTSTNIVTEWVWAPTTLRTLTTTYQILTTRTHIETVFAEPSTVVIYN
The following text describes a protein:
Function:
Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus. Further polymerization triggers pseudopilus growth.
Miscellaneous:
MISCELLANEOUS: Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MRATDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYKLDNHHYPTTNQGLESLVEAPTLPPLAANYNKEGYIKRLPADPWGNDYVLVNPGEHGAYDLLSAGPDGEMGTEDDITNWGLSKKKK
The following text describes a protein:
Function:
Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor. Essential for viability of the cells at low temperatures and at elevated osmotic strength.
Sequence:
MSRLVVVSNRIAPPDEHAASAGGLAVGILGALKAAGGLWFGWSGETGNEDQPLKKVKKGNITWASFNLSEQDLDEYYNQFSNAVLWPAFHYRLDLVQFQRPAWDGYLRVNALLADKLLPLLQDDDIIWIHDYHLLPFAHELRKRGVNNRIGFFLHIPFPTPEIFNALPTYDTLLEQLCDYDLLGFQTENDRLAFLDCLSNLTRVTTRSAKSHTAWGKAFRTEVYPIGIEPKEIAKQAAGPLPPKLAQLKAELKNVQNIFSVERLDYSKGLPERFLAYEALLEKYPQHHGKIRYTQIAPTSRGDVQAYQDIRHQLENEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEYVAAQDPANPGVLVLSQFAGAANELTSALIVNPYDRDEVAAALDRALTMSLAERISRHAEMLDVIVKNDINHWQECFISDLKQIVPRSAESQQRDKVATFPKLA
The following text describes a protein:
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular Localization:
Nucleus.
Sequence:
MARLANLETEYPVLDSTVRNFCASHGIFSVEDFLIHDLYMLAAFAEQNDSSERLKEGIAQVLSVIDDMHQPWLNGMELLEDAKRNKHVFPTGIQGIDLLLGDGIRVGQLTELVGPSSSGKTQVCLRTASNVARNHMVLYLDTGNSFSPQCIAYFLGKTISPSSAQAKNQFLQKVMSNISCHSVFDIFAMFDVLHQLESYLRCQDGRGGCQMRLLIVDSISSLISPVLGSSSTLGVINSKLMDTARALMTSAGYLLKKLAHQHNLAVLIINHTVGGEGGSSKPALGDSWKCIPHSRLFLSCDRGSNTYNVSILRHPSMASGKAARFVI
The following text describes a protein:
Function:
Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Miscellaneous:
MISCELLANEOUS: Present with 2190 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDEVLPLFRDSHIPQIKDYQLELQNDLTKTNEAFQKNLLKNYNKILSLTDSVNDLSLNLKNVDQDFKSLCFNDEKFQLNKLTPLPYQTTTHISPPRDEEKVSIPSQNILVISNWTISINNFCNRIVTSTTPSRIFDELLLNFHELSLIPVPSKFEALVKDKCCRLQKFLVDSMKTLNLTLLQWVKLYNLLNTEFSSKWDDDLLSIFNESLFETLFNDNVQALLISSANSKDHQYHSNQQYKDAIVVDFVNSSTFRDHLIRRTVKEINTHLDTLSTLRAKLKEPETLHKLDIFHDNDTNLNDGTVSPLDDDALKQYIDTAVFYSKGLTNDTTLQIYQTVQPTIEILQNLELYKCPQETLTDLRNKLITQLQEFKTQISSRLPSPLENSTSVVDDFITSYNNHNLLQLVIDQITQLRQQ
The following text describes a protein:
Function:
Metal transporter that transports the trivalent cation aluminum (Al(3+)), but does not seem to transport divalent cations such as iron (Fe(2+)), manganese (Mg(2+)) or Cadmium (Cd(2+)). Involved in Al tolerance by taking up Al in root cells, where it is detoxified by chelation with organic acid anions and sequestration into the vacuoles.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEGTGEMREVGRETLHGGVVQSVSETDEYKEKTIDSEKDGQFRVQPRWRKFLAHVGPGALVAIGFLDPSNLETDMQAGADFKYELLWVILVGMVFALLIQTLAANLGVKTGRHLAELCREEYPHYVNIFLWIIAELAVISDDIPEVLGTAFAFNILLKIPVWAGVILTVFSTLLLLGVQRFGARKLEFIIAAFMFTMAACFFGELSYLRPSAGEVVKGMFVPSLQGKGAAANAIALFGAIITPYNLFLHSALVLSRKTPRSDKSIRAACRYFLIECSLAFIVAFLINVSVVVVAGSICNANNLSPADANTCGDLTLQSTPLLLRNVLGRSSSVVYAVALLASGQSTTISCTFAGQVIMQGFLDMKMKNWVRNLITRVIAIAPSLIVSIVSGPSGAGKLIILSSMILSFELPFALIPLLKFCNSSKKVGPLKESIYTVVIAWILSFALIVVNTYFLVWTYVDWLVHNNLPKYANGLISVVVFALMAAYLVAVVYLTFRKDTVATYVPVPERAQAQVEAGGTPVVDASAADEDQPAPYRKDLADASM
The following text describes a protein:
Function:
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).
Sequence:
MASIPEERSAEHRARSYQLEMFEASLKGNIIVVMGTGSGKTQIALLRIIHELENSDGKLIWFLAPTVPLCLQQHRVISQHIPAVKSRTLLGSDKVELWTEQAVWDAVLEGLQVIVSTPAVLHDAMTHGFVRISRLGLLIFDEAHHCIRKHPTNMIMRNFYHPALQEYGPGAVPRILGLTASAGSSREGLQTIEMNLNSVCTTPQAHRQELLEYTHMPELRRVLYTPLMKENASLWEGSTLQKLLERDNTYCSGQMKTFVCKAVHIFQELGIWAAEYFIRASVEELLSHAYVHSKIDLDYDEREYLVNILSKSPVPDIDVHSTDPKDFPVSPKFEALISFLMSTEDINFSGLIFVEQRAAVTVMSYLLSTHPSTRDRFRTGSFIGMSNSTNRKTMLGDLLSAKMQPDTLDDFRYGRKNLIVATDVLKEGIDVSACSVVICYNIPKGFESFIQRRGRARRQNSTYSMMLSTEDDGSTLDKWQKFEKIMEEACLEDRRRTEELRALGSLDEDVCTRFCVRSTGAILTAEYAMQHLVHFCDTLPRQNYVEDKPEFSFERNDGGLLRAKVILPSSVNPKVRRAEGKAWWKTERAAKKEAAFYAYKALYEHGLVNDNLLPLTKSREFTRKDISLLPAVQKVSEQYDPWVDWAHLWSSTNLYQNRILVRQNEEDTSMKFITPTATPPIAPMKLCWDSETTYTLEFEAAGAVSLTAENIERMRAATSLYLQATTSTPLAGNKDYIALFGPDLPWDELETWLKKNQGHEPAIQVFSSQRPLDRMGVVRDRSRYGELLIFKRWLNRSGDLELECDPYPSKRRNLLQRQTLAKKRPAEDEILGSPTKKRILSASHCTIDRLPASETVFGRFIPVILDRLEAALVATRLCETVLRDIQFQDLRHVITAITMPLAQAPTDYQRYEFFGDSVLKFTVAASLFYNNPNWHEGYLTETLHALVQNARLTRAALDQGLDAYIISNRFTPRKWSAPLISEKLYASASTRSMSAKVLADVVEALIGAAYIDGGLHKAQSCIVRFLPEIELPETKLPRPESMPMSKDHKKPHLIQQENLENHIGYTFKDKTLLMEALTHPSCPYDTSIQSYQRLEFLGDAVLDMLIVDLIRAHHVECQQGEMTKIKHAIVNGHLLAFLCMQFKWAMPSPLTPSIDTGTETETEIISPPPKTLSLYSYLRYSPSRPLPLHVEPESGSSNALTRHNLLCPSILHALNNTTAYPWSLFSAIHADKFFSDVVESIIGAIFVDSGGDLGACAGFIERLGLVRIAKRILDERVDVTHPTQRAQIELQKLAARLGCNDGFRFECRTVRDLSSGKRKTLEVDINDHYGDEDPAVLGAEGPELTYTCTISLATLRTNQDFGRDLDDIVVTGCLSKEDAEIQAANLVIELVGRLESGRLYKKNMDLDIDTGVQVDLDLDMNLDPGITTG
The following text describes a protein:
Function:
Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2); Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Secreted, extracellular exosome.
Sequence:
MADPENLEVMVKTLDSQTRTFTVEEEITVKEFKEHIASSVNIPAEKQRLIYQGRVLQDDKKLKEYNVGGKVIHLVERAPPQTQSPSSGGPSGVGSSSVPHNGAGPRGTGPTVHDRNANSYVMVGTFNLPVSIMDPQPPTQSDGSSVDVHINMDQAPIQSEPRIRLVMAQHMLRDVQGILNRLEGRTNGQAPSGSEEMPSASPTEREPMEGAESEPSSEPTAAEETPPSGTEPPPAPDAATPNHPSPSEYVEVLGELRGVENRLQPFLQRYEEILGTAGSADYNNNTEGREEDQRIINLVGESLRLLGNTFVTLSDLRCNLSCNAPRHLHVVRPMSHYTAPMVLQQAAIPIQINVGTTVTMTGNGSRGAQTSSEGSTASQTSPPAQPGTSTPPDAGRPTEGSPPAASSPGAAPTQTQGSQTGHPRVIRISHQTVEPVVMMHMNIQDSSSPMGGSGTGGAPPAGTPGPIGHTPGMGGAPHMPLPSLPPEFMQAVAHQITQQAMAAAASAAAGQQVPSFQSAPTRVMIARPSAPSVRPTHPGSPQAPGQGPPSLGGNASLAQMISGLVGQLLMQPVIVAQGSGTTASAPSSVNTQATFSTSNSASPPTASASAGTTNTATTAAGGSSAGAPGGPIPSSQPPTAGAELQLSQLSQLLGNFFGATGSTMAGMAGVGSPTITVAMPGVPAFLQGMTDFLQATQMGAAPPHPPEQSPPPPPPQPEATPPPPPPPSAPQSGTEAPSGSVGGSGVRGGASSADAPPPEFFTSVVQGVLSSMMGSLSAQQCSTESIADFIQRLSGTSNIFEPGTEGALGFFGDLLSLICQNFSMVDMVMLLHGQFQPLKRIQPQLNRFFREEYLHGQEPTDRNIQMATYNLINGLEDYIRESFASVRVRDGVDITRTNLEFLQEQFNRIATHILRCTDNTFGYRLLELCNQGLFECLALNLYCLRGEQGALTAVINDRIRRMSADMNPSLVSWLTTMMSMRLQVILEHMPVTEEQVLQYVRRVGDPPQPAPEEPMDLQTVEQAPETLQRDSVASPAPATTAEEAMPQQRGEPEHEEPQQAEPPAPEAEPWAAAVPPEWVPIIREDIQTQRKLKQQPPLSDAYLSGMPAKRRKTMQGDGPQLLLSEAVNKAAKAAGVKPLTSTESLSRDLAEPALQEGYRQQLKSDLQKRLQADPSFTPQRFPNAQQVFVAEDP