lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASLTRDVADFPVPGVEFKDLTPLFADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYRAYGAATLEILAEGIEVAGRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MRMHSKSRGAMMVEAAKKNKDAQKSPVRSTKSSLPLVPSTPQKRKDPRPSQLIQYGKEKPDNNLDALFKRRKEQQQSISGFRGMENLGNTCYMNAVLQVLTSLDTFASDMQNKQLLDASMPEDGVYKALLQVTKEKKLTGMSRGINPVALKRSVAKNSSRFEGARQQDAHEFLCNLLDQVQEEVFHHYEKKLLPQDSSKLQLQDTRCPTSLNFSCIVEHELVCDSCGESSEVRELFRHLSLDIPERKPGEANGPPNLQELLELYFKDEPLEKTCEKCGCLTCTVKHRVRRLPRVLVLHMKRFCVKIDGPVQRYVKRQDPVRIEPLLNLRPVCCPLTKGPIPFGDQARPSPSQNKAPKTPQSPRRTLADVSNTWQAAAGESPAKSARRASISASSGAFLGPEAVGRIRGGFSVASDGSSGSGIREGSDVDSGETSGERNEGSDVRMDEANAEGDACPEEDTASSMEGVEQEPRRCFSHAELASIEPQRLRGGGAEPDSDPYALEPTASELLEQSMSEALERTMRDRAAEMEAVNSGRIAERKRASAEAGLSARKPDSIYTRASPYETSDNPYEAYKNLPPGARFGTATALKVAERSQTPGTQTPRLSATAGKRGEPVIRKPGKSISTVKNLFKSAGEKREEEAAMLFSPGSKRPKTRAERAESRIASVVDLEPDEDAELARVLAESEKEFAAQRGGDAGQAGADVSREQEQLDRAIALSLQEAAAAIEREDVPTPAPGLDRAAPSSPTVEIADDAMSGPEPPEPFSTAYRLHGIISHLGTLASSGHFIADVYDTASEQWVRHDDSVVTVVSRSTVLNEKREVDGYMFFYVHEPLVKQQKLGYQQARDSSKLKLEGRF
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase.
Sequence:
MSQKQKPIRFQDYQFTATKDEAYGRSDRYVKQFLNKNLLKKKDGTLGTAEELLTLIQQSNINVVTASTGGAAMGAMLNHTVSTINLTGSGSVPTYNPSDNRNSGSHVITSTNSVISNSSISSTGVINNNINNNSNINSNTGTTTTTISLPNNTEIKTALVSTGSQNASDTAQIDIEFHLSYTQLVTLPPSIFSLIWIQKLVLTHHNIKTLSEDIGKLQQLQVLVLENNRLINLPQSIGDLVNLKRLEVDNNHLVSLCSLERLSKLEVLSVNNNKLTLLPTSIASLSSLKTLNIKSNPIITPPSTVVSKGLKDIVSFLRELETGARPCLRSKLVVLGDPGVGKTSVVQCMKGKKKKTNVTSSSINIGGSSGSEVGIEIDQYDFDVVFDEDDKKRRVITLSTWDIANQDVYFASSQLFDSERSVYIVVFNLNNDDFSAIEYWLHCIMSTSPNSPIVLVGTHIDAFENLNVVNAVLESVASRFQKRFTNIQAIISVSCTTGYDVDKLRQLIEDIIKTQPYLKEKVPSSFFTLEEALIEVKKKRIPPVMMWQEYINLANICNLKDSVQIQRATEFLHNIGSIVYFNDLNSSTVGKMVILDQQWIINCMSSLITSKLLINNCNGIVRQSDLELVWKAPTYPEHLHPALLSIMQAFEICRSLSPSDLVRPEEVNEKEVMGDRNLVPNLLSDNTNIVAQWDDFIDPDTILLNRQYHLPFLPEKFFGKLIIHLMNFTKVESCQKRAVILRNQDNHEALIELKTIKDNKDGTFKKILTVDVRGLVSPVSLLRIVTDTIESLFSQWYKLDIKRYISCYECAILYDRNPTLFTIEECELAVIDGKTVLTCNQKSDSDRVSTSHRLKLDILAPDISMVDIPIPRFNLSEVKINKEVGRGAFGIVYEAEWMSEWIALKKLLLPSSTDTTNLNGNGEVMVYDDPDQLIEDRLRVFREFRHEVYYMSGLNHPNVMKISGFCIQPLCMALEYVRYGSLYSLLSNSSIEISWGLRLQIASEIAKGMQHLHSHNPPVIHRDLKSPNILLNGITEGQNSVATIIDFGTSTALYGGAALIRCVDQPLWLGPEVLAGTAYSEPSDVYSFGIILWELYTRAHPFDEFQFGQWMSKLEDEIIRGLRPTIPPTCPPEYVELIQSCWTHEPNSRPTFTSIVEILGQIKKKFAPLPFTHPPHIRNMMRKSRSSSISEAMLPSNLLHLNLNGINNNNNNSNNNNNSIPVTTISLTSSGTSPTNSPVGGLLSQSLTQPITSGGSTSGILSTSVNRDNSSLVSASSLGNNTSTSSLASLVSNNSGLHHSPSASDGLNDYYGADNNNNNNDSTMDFFQDIFTEEENEQPYPFADDDQQKGILFGFDEEQTNPSASSVSIIIAATMAKMIEMMTKGESSATLKSEHISTRRRSDTAGKNGVPPHWRNSVPLSTNSSTTLDETFIDDFIYVYRSFTTPRNIFKLLVRRFFGPRHTDKVDTFTIKKFEQKKAAIRQGIAVFLRKWVADITELEFRQEEFWLYHNTVAFTKQFIASEFPTIATQIYGTLTTHEDEVNLTNQRFLQIAFSESEIQIDRAMSSMQLTTPKPFRSQKNLANSYNSQSGGGDSSFYYQPSSNDVSRVFLNLATGMRDPLLGITVKEKKFKKDKVSTLCCSGSEIIDWITKCMPIKREEASILVLDMLMKQFFIQISDDGIPISNQKGTNPTFSDSPTSFYMFLEDDPELIARQYTFLELKYLQNIHPRELLGFSVGLVMPNENEKDPEKWRQSNFPHIYDYFRWFNKMTMLVSTEILRQRDIKQRASIIEKYISIALEYLSLWNFNGIMQVLSSLHSEPISRLSATWAKVSQRSMDCFYELSRLMLPESNYLPLRTALASQKPNTIIQASPLYPNISAYMVHTVCPTIPFLGALIADLSQTCTENPTFISSGGEKMINILRVKRLSKKMKMFKEYKEMPTQYLPALTTIPLQYYEHYVNDLKALDSLQIDRLSDIERKLEIICEKNGTTNDDKEKGDENGGGLTSSNFFGNGSDELTERDWTILLTNASVIAYNRGDVVMEENAINTHLYRIKSGAISVEKKDKEGINCKVATMFAPKMFGEMSFLGNKTTARLTVDEESDLYVMDIPFLNNLFNGHPRLGAKFYKIMANQLAIRLKNLPWSKPKNTTGGSSSSNQSAGPDNILGTTPTGISSSGGGLTSLLNQNLSSIMSLSNSNTPPASPRVMTTPTLPSPPAPLQSPPTSGISSPTTTTSTTTDQQKINNTIFQNVHPTINVHRTSSSANLVSPHGRPSNSGFGHSSGGERTINKDPHQRDSGSMDKPILSLGSGGTPRGDGARSGSISYLGRTQTSTSPLNEGLSGGQQPVMKKNDQEFCQRFALVDEIVIKDYPCSLNRSGRLYISQQHVCFYSKFFGYKTKKVIPFKNIDKLICINVNQIELTRLKNTVPSNYRLTFQTGKDREDAFSMIHILWDSSKVSNSSSDEIKNKLAAERKKVNNLTLKTRSNKNKGDELTKEDWELIGCEGSRSSTFKKDEVIIREGERMQKIFQIGKGVCRIEKSVPVAPGSSEMKKVVLGTMKQDDTFGEITYLLNGETTADVIADTDQTEVYTIEGQFVNILFDLNPALASKWFKYLATALNKTLIERESQLYA
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAIDDLPPLREVIRQHALSARKSLGQNFLLDLNLTARIARAAAPLDNSTIVEIGPGPGGLTRALLALGARRVVAIEHDERAIPALQDISARYPGRLEIVHGDAMTFDPRPLLNGESAKIVANLPYNIATQLLINWLTTEPWPPWYDMMVLMFQREVGERIVAREDEEAYGRLGVLANWRCETKILFDIAPSAFVPPPKVTSSVVRLVPRAEPLPCDRKMLEQVAAAAFGQRRKMLRQSLKSLGVDPARLAQAAGVDATRRAETIPISGFVAMARELADIRSEG
The following text describes a protein:
Function:
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
Subcellular Localization:
Cytoplasm.
Sequence:
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRKETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTATETQCSVPIQCTDKTDKQEALFKPQAKDDINRGAPSITSVTPRGLCRDEEDTSFESLSKFNVKFPPMDNDSTFLHSTPERPGILSPATSEAVCQEKFNMEFRDNPGNFVKTEETLFEIQGIDPIASAIQNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDHNALYVNSFPLLDPSDAPFPSLDSPGKAIRGPQQPIWKPFPNQDSDSVVLSGTDSELHIPRVCEFCQAVFPPSITSRGDFLRHLNSHFNGET
The following text describes a protein:
Function:
Catalyzes the conversion of ureidosuccinic acid (USA) to dihydroorotate, the third step of the de novo pyrimidine biosynthetic pathway.
Miscellaneous:
MISCELLANEOUS: Present with 12700 molecules/cell in log phase SD medium.
Sequence:
MVQEIDLGLTCDMHVHVREGAMCELVTPKIRDGGVSIAYIMPNLQPPITTLDRVIEYKKTLQKLAPKTTFLMSFYLSKDLTPDLIHEAAQQHAIRGVKCYPAGVTTNSAAGVDPNDFSAFYPIFKAMQEENLVLNLHGEKPSVHDGDKEPIHVLNAEEAFLPALKKLHNDFPNLKIILEHCTSESAIKTIEDINKNVKKATDVKVAATLTAHHLFLTIDDWAGNPVNFCKPVAKLPNDKKALVKAAVSGKPYFFFGSDSAPHPVQNKANYEGVCAGVYSQSFAIPYIAQVFEEQNALENLKGFVSDFGISFYEVKDSEVASSDKAILFKKEQVIPQVISDGKDISIIPFKAGDKLSWSVRWEPR
The following text describes a protein:
Function:
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
Subcellular Localization:
Cytoplasm.
Sequence:
MTAENGAQGAVSPSLNILAQYIKDLSFENPGAPRSLQGRENAPAININVNVNANPISGSDFDVVLTLNAEAKDGDKILFAAELVYGGVFRIAGFPQEHMLPVLFIECPRLLFPFARQIIADVTRNGGFPPLMIDPIDFSQMFAQRVAEEQAKAQVQAVPN
The following text describes a protein:
Function:
Important for the overall degradation of proteins in lysosomes.
Subcellular Localization:
Lysosome.
Sequence:
MWAALPLLCAGVCLLGAPARGAAELSVNSLEKFHFKSWMAKHHKTYSREEEYHQRLQTFASNWRKINAHNNGNHTFKMAVNQFSDMSFAEIKRKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGHFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNNGIMGEDTYPYQGKDSDCKFQPGKAIGFVKDVANITIYDEDAMVEAVALYNPVSFAFEVTQDFMMYKRGIYSSTSCHKTPDKVNHAVLAVGYGEENGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPVPLV
The following text describes a protein:
Function:
Transcription factor which negatively modulates activation of the mitochondrial unfolded protein response (mtUPR). Plays a role in response to infection by the Gram-negative bacterium P.aeruginosa.
Subcellular Localization:
Nucleus.
Sequence:
MQPSYDADDFMRRGFFGSFIGFRKRSSSKPEPPVPPKFAPPAAPSVAPNFRASDSAAPHLLSVPSNRTEYDIYREIVSEAEYIERSSPASPDFSCPTTPQPSNYYTPLPLPQQPPTFDPSTLMPQQQMMFHPGQYHMVMSPIAPHPIPVDTNGVPLGTQCPMAPPPYSSFAPQSSSSGMLQQQPQDLVIPQDIPFDVKREIQEHLVLQNGKKQMSIEEIVKLVVVALKDSQIEEGREEEESPEEILRRKRIQNNLAAARYRKRQREARESAESELGDLTRRNDELRDQVSRMEREIDRLKQAVLGRQ
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MALHLTFLCAKAFFCCQSPVKKATSMDSSLTAAQIREKFIDFFRRHEHQYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMARLRRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKHLACKMALELLTQEFGIPIERLYVTYFGGHADAGLEPDLECKQIWLDLGMEESRILPGSMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNMDDPNVLEIWNLVFIQFNRESETVLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARAYTGKVGAEDTDGIDMAYRVLADHARTITIALSDGGRPDNTGRGYVLRRILRRAVRYSHEKLGAQRGFFASLVDVVVKSLGDAFPELRKDPDMVKDIINEEEAQFLKTLSRGRRILDRKIQSLGESTTIPGDTAWLLYDTYGFPLDLTALIAEERGMGVDLLAFEEEKKAAQLKSQGKGSGDEDHIMLDIYAIDELRNKGVAATDDSPKYKYTSDDNGNYEFEQAVGTVLALRRERMFVDEVITGQECGVLLDKTSFYAEQGGQSFDEGYMLRENDSAEDRMEFTVKNTQVRGGYVLHIGTVYGTLKVGDRLTLHVDEARRRPIMSNHTATHILNYGLRSVLGEADQRGSLVAPDRLRFDFTAKGAMSTDEVRRTEEIAAAMIADAKGVYALDAPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVEELLADPNSPAGSLTSIEFCGGTHLQNSSHAAPFVIVSEEAIAKGIRRIVAVTGAEAQKAQRKADALKLSLDALAEKVKAQSIPNKDVQKEIADMTESLGTAVISQWRKDEMRESLKGLKKIMDDLDRASKADVQKRVLEKTKEIIDSNPNQPLIVMEMESGASAKALNESLKMLKTNSPQTAAMLFTVDNDAGKIICLCQVPQDVANRGLKASEWVQEVCPLLDGKGGGKDMSAQATGRNTQCIQEALQLASEFARLKLGEN
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Sequence:
MSSRRKRAPPVRVDEEKQQQLRWNMHEDRKNEVLILDDDDQPVPGPSSSSVPFVVLDDDSPEEEVTPKIKRRCSKSVSSLTDEEETACILPSILVKLNVVISPFHIDSSWKAFLGELTLQLLAEEILIESFHERKFTLMTADSSDQLQICVHPKCKEVEDQQKGLEELISVSEKSILVESSFSNEMLEDLRWLQKKRIIELYHRPEGIQTIKVGIYLLEAGLAKPDFLSDGSGRIKKANQLIQKLMEKFYNFIIPDVLEEDEEESDSELERQNIEELYDFVRHTHQQEAQHLQENVQHPALIPVLRPYQSEAVNWMLLRENFRNSPANENALHFLWREVITTEGMTFYYNPFTGCIIREYPNAGPQWPGGILADEMGLGKTVEVLALILSHTRQDVKQDVLTLPEGKLVNYFIPPQPAEGSKKKKPKKMEFQSKEKIQYPSLRVMILAAVKEMNVKKGASIIAIFKYVSTIYRYDVQRNRRLLKRNLEKLIAEQVVEQVKGHGLAGSFKLGKNYKEQKKCDRTKKQTTKSPRKSLNKFSDEEKHQSESKDTVSENKEEKSLSSNITEEEHDYCEVSRDHGRLRKKRDQHSNEKLQPKAKELRSADLQRSSDLPSTHVTVSKSEPNSEEDNMKDQVSESQDHAGSEIPHANSISPFNTSDYRFECICGELGLVDYKARVQCLKCHLWQHAECVNYKEENLKIKPFYCPHCLVAMKPVSTGATLIISPSSICHQWVDEINRHVRSSSLRVLVYQGVKKHGFLQPHMLAEQDVVITTYDVLRSELNYVDIPHSNSEDGRRFRNQKRYMAIPSPLVAVEWWRICLDEAQMVECTTAKAAEMALRLSGINRWCVSGTPVQRGLEDLYGLVLFLGVDPYWVKHWWDQLLYRPYCRKNPQPLYNLIAKIMWRSAKKDVIDQIQIPPQTEDVHWLHFSPVERHFYHRQHEVCCQDALAKLRKISDWALKLSSLDRRTVTSILYPLLRLRQACCHPQAVRGEFLPLQKSTMTMEELLTSLQKKCRTECEEAHRQLVCALNGLAGIHIIKDEYPQAVDLYREVLRSSEEHKDKLKTDSLQRLHSTHNLMELLLAKHPGIPPTLRDGKLEEEAEQLRQHYMSKSNAEVAEAHQALQPVLQIIRELQRKTHAGSPWWLDVIQSAIQYAIDEELVQRVQNEITSNYKQQTSKLSMAEKFRDCRGLQYLLTTQMEELKKFQKLVREAVKNLEGPPSRDVIEAATICHLRPVRLPLNNCVFCKADELFTEYESKLFSHTVKGQTAIFEEMIEDEEGLVDDRLPTTSRGLWATSETERSLKAILSFAKAHRLDLRLIEEGNTSMELFEAWKKEYKLLHEYWMVLRDHVSAIDELAMATERLRVRHPDEPKPNPPVLHIIEPHEVEQNRVKLLNDKAVAKSQLQKKLGQLLYLTNLEKSQDKTTGGVNPEPCPICARQLGKQWAVLTCGHCFCNECIAIIIEQYSVGTRRSSIKCAICRQTTSHKEISYVFTAETANQEEDIPVKGSHSTKVEAVVRTLKRIQFKNPGAKSLVFSTWQDVLDIISKALYDNNMVFAQINGINRFQENLSAFKYDPKINILLLPLHTGSNGLNIIEATHVLLVEPILNPAHELQAIGRVHRIGQTKPTIVHRFLIKATIEERMQAMLKTAERSHTSSSMKQSEASVLTVADLADLFTEETEELE
The following text describes a protein:
Function:
Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes.
Subcellular Localization:
Secreted.
Sequence:
MKGSCETTMVKSLLLLMLGFAIISSGAARRNPKVGLSALQKAGNCPPLEDNSVRVDIRIFNQNQGISVPRDFQNRSSSPWDYNITRDPDRFPSEIAEAQCRHSGCINAQGQEDGSMNSVPIQQEILVLRREPQGCSNSFRLEKMLIKVGCTCVTPIVHHAA
The following text describes a protein:
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein.
Sequence:
MRPGHAVSGGADLLSVCLFSQGSDGARRSTLLDSDEPLVYFYDDVRTLYEGFQRGLHVSNNGPCLGSRKPDQPYEWLSYKQVEDMAECVGSALLHKGFKAAPDQFIGIFAQNRPEWVIIEQGCFTYSMVIVPLYDTLGTEAITYIINKAELSLVFVDKPEKANLLLEGVENKLIPCLKTIVLMDSYGSDLLERGKKCGVEIISMKAMEDLGRANRQKPKPPVPEDLAVICFTSGTTGNPKGAMITHRNVVSDCSAFVKMTENTFIPTSDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKALQPTIFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTVAGDWTAGHVGPPMPCSIIKLVDVEEMNYLAAKGEGEVCVKGSNVFQGYLKDPVKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYQRSEPIAQVFVHGESLQAFLIAIVVPDVETLGTWAQKRGIVGSFEELCRNKDVKKGILEDMVRLGKESGLKPFEQVKGIYLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDELYSTIKV
The following text describes a protein:
Function:
Has a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MDSFGNQKHPMRQQQQQQSPGYPDQSSWGGTQQNAMLEIGMQYGQNVLQEKSQGFMSYISVVTGFRRYFRVDNQYVKRKLTMLLFPFLFSMKKTEGYSNNDYEERRYPSGFGGDSPPPMQGGSWSPTSTQSTEQVPPPTEDVHAFDLYVPLMGAITYVILSGFLYGLHHNSVPNEQLVGPAWSLLFWLQVEVFILKLVCHLLRTTPASTILELTALCSYKYITICLAVLLREVLRLEGETVYTWAILLYVVLANATFAAKTLMRSHQREQRVPYNAKVFAYVTALLQAPMTLWLAIRPFQ
The following text describes a protein:
Function:
Required for the formation of DNA double-strand breaks during meiosis together with narya and nenya.
Miscellaneous:
MISCELLANEOUS: The name 'vilya' derives from the fact that this protein contains a RING-type zinc finger and vilya is the mightiest of the three rings of power given by the elves of Eregion in J.R.R. Tolkien's books.
Subcellular Localization:
Chromosome. Note=During early pachytene, colocalizes with narya to the central region of the synaptonemal complex (SC) in both linear stretches and discrete foci which correspond to recombination nodules. As pachytene progresses, found mainly at recombination nodules. Double-strand break formation is required for recruitment to recombination nodules but not for linear localization to the central region of the SC.
Sequence:
MAKSQAGQTVEPEASKLWIHCNSCCALFCDKKHTFFLLACHHVFCERCVKVSAGRTPSDAPIFECSTCRRSVRGRQLTNSMPNHFKQLFHPEPFTIGNDFVETFQRGNHRHFDKYKERKELEMDKLFKDIEVAKSVCQKRFLEAQMLRVERKKLMQRSRYIKAEVANRKAEMHRMAQAYRSRSLTSQSSSSAQRSARGRPRGRGTATQSSSRRRSTESAKRQQITSFIHPPNNSFDL
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
PDAFPELSELSVSQLTDMNEQEEVLLEQFLTLPQLKQIITDKDDLVKSIEELARKNLLLEPSLEAKRQTVLDKYELLTQMKSTFEKKMQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKMEIDDFLSSFMEKRTICHCRRAKEEKLQQAIAMHSQFHAPL
The following text describes a protein:
Function:
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes.
Domain:
The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site; The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
Sequence:
MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTSGTLSTHMDQQFFQT
The following text describes a protein:
Function:
Involved in the uptake of the purine ribonucleosides inosine and guanosine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITWFMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVTFFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVLSNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPEDEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHGLTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHTVAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIVGLFVW
The following text describes a protein:
Function:
Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.
Subcellular Localization:
Secreted.
Sequence:
MRATAIVLLLALTLATMFSIECAKQTKQMVDCSHYKKLPPGQQRFCHHMYDPICGSDGKTYKNDCFFCSKVKKTDGTLKFVHFGKC
The following text describes a protein:
Function:
May play a role in cellular stress response.
Subcellular Localization:
Cytoplasm.
Sequence:
MAASTKRRGLTEPTVIKDITKSWPCFRWDVEDLSELLGDDKIRFRLGRKNVEGSGFEFEGDCIYEEATMKDFCKWCRQNSTEADDLPQTISCMSPSIESDSDCIDDPKVHGLKHSEESAHPTSEGSSNPLMFYDRSRYWCYADYKHMKQLFKNCPSVLEDVRWRDLGFDRDGGQSTIWIGSEGANTPCHQDTYGFNLVAQIRGRKKWHLFPPSQTELMYPTRIPYEESSVFSQVNVRSPDLQHHPKFGRATPYVAVLHPGDILFVPKSWWHFVESLDTSISINCWMDLESDHVSRVDEAIARTLVCGLMSLEGHEADDQESVARWLNPTEEATSASTNLALLGDAVDAAFTHYSKTSHEMEENMPEALINLKEGDPSLRHCQASKRNTLKEQFQRNVDSDEKNGGDASVNMGEKASHVEAMNLGNTKGMSSYQQTSHSYYPSTLSTPPITTDPIDDGRSTQGLLVDSDSTCVKPGGGQSGMEGKDRGQNQSNSVKRIKLCDNVTIPGSGMMVARQSVFPVPCHGSVTQLTASRRANDCANLKIEQETGVPSSATLETSDSFVDVTMATLVECLTQPNIIALLREGLLEKVRDKQQTRTPDD
The following text describes a protein:
Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Sequence:
MSIFVPESPGLLLAANSTIPTMIKQILAKLPRKSSKSNQNYSDGSNATAAADLTNNGSFTNTCNVISSRLNVVKKMSSSIFPTSNGDMIQPHLSFKDVQSSEKSRLLISKLNLCSIVYDFNDQDKDNVEKDQKRQVLVEILDYLGSDSVKLSEPAMSAICKTCGNNLFREFPPKYSDSPRGETEDEDPWFDPAWSHLQLVYDILLRFVSLTSLDPKVAKQYIDHPFLLKIYGKFMVHRSFIRMAVSNIMYQFVYETEKHNGIAELLEIFGSVISGFTLPLKKEHKAFLSRVLIPLHKPKSVGSYHHQLTYCVVQFIEKDPKLTSVVINGLLKYWPVTSSQKQLMFLSELEEVLEIIRTDEFEKIMVPLFRRVKCCLDSYHFQVAERAHFLWNNEHIRHLIMCNRQVIMPIVFSSIQQNSKKHRNRTVLNLAQNVMKMFNDADEQLVLSCQGKAEEDKSATTMVAERRRLTWERLETVASGGFGFQHIVGSVSVLEKTDTTTCVSCQ
The following text describes a protein:
Function:
Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
Sequence:
MDRYDRQKRLWGASGQQGLRHAHVCVIGGADGGLWCEVAKNLALSGVGAVRIISTGSSDDSYERFFQPAELCSLNTDVGWSFSSWKGAAVAAEQWSECSALIVTTGAPGVVEEVTAKWRERKMPVLLSAHCASVYGYVRLLSPETHCVIEAHPQHRVPDLQLYAGWGELDELCGKTAVSQLDPEERQDVPFAVLLRSAVRSLGRKPASREEARAALDDLYTPNHSGATIEDMNFLEAVKYAHLALAPTEPVLPRVAEAWAAMPPDLEQVGDPFNRQFWVLVRALKQYFTAYGSLPLSGELPDMESSTVRYYELKDCYEQKARADRKRLAGFLSSTIPDAVIDAFCRNLRYLRIIRPSKLIGLDESLSELKRVNTDGAMLLSALLSIQYGIQEPTVNKKGSEYLNNINRFSGSNFYPTVAFIGGVLAQEATKFLTHQYVPIENTFVYDGLLNTTETIML
The following text describes a protein:
Function:
Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme.
Subcellular Localization:
Nucleus.
Sequence:
MEGASNGGMLYHEVQESKLCAVHCVNTVLQGPFFSEFDLAALASDLDRRERQMMMMPVPGVGGVGGGDFLSQESHNVSLDGDFSIQVLEKALEVWDLQVIPLNSPVAEPAQIDPELENAFICHLQDHWFCIRKVNGEWYNFDSLYAAPQYLSKFYLSAYLDSLKSSGWSIFLVRGNFPRECPISSSEAPSGYGQWLSPEDAERIIKSCNTTQPPPPPQRSQTDHTLSDMEAEELEAAIAASLMDTPAATPQVSEVATPQASEAATTQAEKETR