lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Specifically methylates the guanosine in position 745 of 23S rRNA.
Sequence:
MSFSCPLCHQPLSREKNSYICPQRHQFDMAKEGYVNLLPVQHKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIVAQLRERLDDKATAVLDIGCGEGYYTHAFADALPEITTFGLDVSKVAIKAAAKRYPQVTFCVASSHRLPFSDTSMDAIIRIYAPCKAEELARVVKPGGWVITATPGPRHLMELKGLIYNEVHLHAPHAEQLEGFTLQQSAELCYPMRLRGDEAVALLQMTPFAWRAKPEVWQTLAAKEVFDCQTDFNIHLWQRSY
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.
Subcellular Localization:
Nucleus.
Sequence:
MERQQIIESLRRIIPTESTEYNERLISLGESFLEWSKYKHNLKATEELCRPYMAAHLACELLSNDLNLEINLLATPIPKKKYYKLFTYFQEILSPLTKSLAAKDDLMETITYLCTKLGGSTAIPYVKQLVKAVVTNDMRIEHKRGIIIAAYLLVSAKAFGKDELHINHTERRKAQSVLQDTSSALQIQYWMHVLSESWQYKEIPLNGIEGYESQKQRIKPWSGIASMIQIDYEKRLQNYPIWKACIEERIQYYKSQLEKDGTAS
The following text describes a protein:
Function:
Involved in the degradation of cineol (eucalyptol). Catalyzes the reduction of cindoxin (CinC).
Sequence:
MSKLQHHSIGEVEPSIAIVGSGPAGCYTAQTLHKQWPSAQIVIFERLPVPYGLLRYGVSPDHQGTKAIARQFDRLFAEASVHFIGNVEVGKHISVEELQDAFDVVVLAAGLGADRPLPSLAGDAVYGAGQVMRWFNSHPDEQSFAPGFGATTTIIGNGNVAMDVVRLLAKHRDSFTGSDLDPQLIEKQPSRIHVVGRSPASAAKFDSMMIRELAEIDDAVFDVDVVDEPGHEDKRIHAKTKALLDLTAARAVPSPRVHVSFHFGWTPESLEPTGDGRTLRLVNTESRLAVKLIETDSVITAVGFGSGLRHEIDRVRFESAASDLDNGLLDTGLYCSGWFRRGPTGGIPANRLDAKMVCTRIIEDVASGAITPKKRGLEELATHLHPDTVDFTGWQRIDAVEASRTEHGRCRTKLPDIATMLDFARNRTHERTTDDTYRKQITDTVGHKEKR
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAANNNRSDQESDENTRLYNPYQNFEVPIKSQYLYKLPTSPEYLFTEESLKQRRSWGENLTFYTGTAYLGGSVSGATVGIFTGVKNFESGDTTKLKINRILNSSGHTGRTWGNRIGIIGLMYAGIESGVVAAMDRDDVWTSVVAGLGTGAVFRAARGVRSAAVAGALGGLAAGAVVAGKQVVKRYVPI
The following text describes a protein:
Function:
Ribosomal protein required for normal mitochondrial function and normal larval development. Thought to have a role in insulin/IGF signaling.
Subcellular Localization:
Mitochondrion.
Sequence:
MLKLASSLRTGLISRSIRTLAPTVNPAEQQQVQAVLPDKLYSSVEIEYRGHDKAVLKSYTSFLQQVCQHLEIPQGRLEVLPYIRWVQPALRSKFVHKKYKLHYETRTHISKLEILNVTGSTASTFLEYIQRNIPEGVGMRVGFTELQPLPLTIQKN
The following text describes a protein:
Function:
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
LEAVSHASDTHYGYGDSAAKEIGGDVLKHAEMVHTGLKEYKDVDKXGPVAKELSGLPSGPSAGSGPPPSALFAQIHQGESITHALKHVADDEKTHKNPADKAQSGPVRXGPKPFSASKPGISPSPKPVTKKWRXENXENVSNLVIDDTELKSVNSTLQIKXXINSISVDNYKVPXISINKXDGRHIYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQXKXIWNGQK
The following text describes a protein:
Function:
Transcriptional repressor for the exu locus which is required for galacturonate utilization.
Sequence:
MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLNYTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDDLKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDKEGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQYDMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGFSQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT
The following text describes a protein:
Function:
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The N-half (TM1-TM4) and C-half (TM5-TM8) domains are connected by an intracellular loop. Each domain is formed from four-helix bundles and they align in a pseudo twofold symmetry manner. The N-half domain is the substrate-heme O binding domain and the C-half domain is the cofactor heme B binding domain; The cysteines of disulfide bond Cys-35 and Cys-42 may be involved in transfer of reducing equivalents from quinol in the membrane to the active site of the enzyme.
Sequence:
MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHGRFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFLQALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKKMQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRAAALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFALAHSFFIACLFGVLCYFLLLIARFRYESRQS
The following text describes a protein:
Function:
Serine protease that degrades the two-component response regulator ARR4. Regulates ARR4 stability by targeting ARR4 in the nucleus for degradation. Acts upstream of ARR4 and regulates the activity of ARR4 in cytokinin and light-signaling pathways. ARR4 mediates the cross-talk between light and cytokinin signaling through modulation of the activity of phytochrome B.
Subcellular Localization:
Nucleus.
Sequence:
MKNSEKRGRKHKRQDASSAENAGGEVKEASANEASLPQSPEPVSASEANPSPSRRSRGRGKKRRLNNESEAGNQRTSSPERSRSRLHHSDTKNGDCSNGMIVSTTTESIPAAPSWETVVKVVPSMDAVVKVFCVHTEPNFSLPWQRKRQYSSGSSGFIIGGRRVLTNAHSVEHHTQVKLKKRGSDTKYLATVLAIGTECDIALLTVTDDEFWEGVSPVEFGDLPALQDAVTVVGYPIGGDTISVTSGVVSRMEILSYVHGSTELLGLQIDAAINSGNSGGPAFNDKGKCVGIAFQSLKHEDAENIGYVIPTPVIVHFIQDYEKHDKYTGFPVLGIEWQKMENPDLRKSMGMESHQKGVRIRRIEPTAPESQVLKPSDIILSFDGVNIANDGTVPFRHGERIGFSYLISQKYTGDSALVKVLRNKEILEFNIKLAIHKRLIPAHISGKPPSYFIVAGFVFTTVSVPYLRSEYGKEYEFDAPVKLLEKHLHAMAQSVDEQLVVVSQVLVSDINIGYEEIVNTQVVAFNGKPVKNLKGLAGMVENCEDEYMKFNLDYDQIVVLDTKTAKEATLDILTTHCIPSAMSDDLKTEERN
The following text describes a protein:
Function:
Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP.
Subcellular Localization:
Cytoplasm, cytosol.
Domain:
Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Sequence:
MAPQQNIMKQLQQMQSSPYPSSSPSSTTVSQNNDNLNHNVHSLNNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSINEKNKINDNNNRGNSDDGNNNNSNNNSNNNNSNNNNRDDEEEEGDDEDNNNNNNSNNNKIRGYNDNNDINDIFSINFSSWSKSKDNLIENGVLIFEESGLYKELNLSKSSILNFLSIVASSYRNNPFHSFNHAIAVTQTIFLILLKTNLFNILSPIEKLSIIIASICHDLDHPALSNRFQINMKSSIAVLYNNKSVLENHHLSICLGILESKIGNELLSTLTVEEKKQFFRRVKILILATDMENHFTYKKQFDDIISTFSWDNSEHRDLLLIMFLKSADISNELRSFDISNKWANALMEEFFNQSDLEKLNNLPLTPFMEREKVVLHLTQVSFIEKFLLPSYQSLQNLLPSLEDFVQRIIENKEIWSNNGSSSSTTSSSPN
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MAVPTGVEDFAEDLRCSICLELFLDPVMLECGHNYCQACITRYWAEIPVNGGADVPHPTCPECRREIPEGKFTANRVLGQLARKAMESLSAHASDEDAETEQNDDEELQGDRLFCTDDGCLVRSLQLEHWGHPCLPLDEAVEHYKEILTAAQASLETRAQAARLLQEQSAQKIPEITAQRLRLEQHLSAQFIELHQWLQEKEAAMKRTLRHEEELLVSELERNQRNGQEQMHMAEEHMAKIQTRLEEHQDPETFLKIPPFSSNIEPYITMSISKVKISRGFNLGQFKGPIQYMVWKEMLPALRPSPCFITLDPATNHPNLVLSKDLDTVRLEDNPEEEVPDGPERFSKSVCVLGAQGFTSGRHYWEVKVGDKTSWDIGVAKESVNRKEAKVTVKPSNGFWAIWLRNGNEYKALDSPSKQLYPKVKPQKVGVYLDYEGGQVSFYDADTMDHIFTFLDIFTECLYPMFSPGVNKNGLNGEPMCLLTPLV
The following text describes a protein:
Function:
Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis. Required for polyadenylation of neg-1 mRNA during embryogenesis.
Miscellaneous:
MISCELLANEOUS: The deletion mutant gld-3 (q730) makes no detectable GLD-3; it is predicted to generate an mRNA with a premature stop codon, which should be subject to NMD. The deletion mutant gld-3 (q741) removes the fbf-binding site from isoform A, but leaves the gld-2-binding site intact. Animals homozygous for gld-3 (7q41) enter meiosis, but are feminized. In addition, gld-3 protein that retains its gld-2-binding region, does not have the dramatic mitosis/meiosis delay seen in gld-3 null mutants. By contrast, sex determination was not normal; gld-3 (q741) males produced oocytes. Therefore, promotes meiosis primarily via its interaction with gld-2 whereas the sperm/oocyte decision relies on its interaction with fbf.
Subcellular Localization:
Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region. Note=Localizes to P granules. Found also in particles near but not coincident with P granules.
Sequence:
MGEQSHEKDHDEAHSYNPFVRSAVEYDADTRLQMAENAASARKLFVSSALKDIIVNPENFYHDFQQSAQMAEDANQRRQVSYNTKREAHIHQLKAQGLPLPSNIPMIEINPTRVTLNMEFESQYYSLMTSDNGDHENVASIMAETNTLIQLPDRSVGGTTPDPFAQQVTITGYFGDVDRARMLMRRNCHFTVFMALSKMKMPLHELQAHVRQNPIQNVEMSFVDAPEKNGIVTTYLRITAREKNQHELIEAAKRLNEILFRESPAPENNFTLHFTLSTYYVDQVLGSSSTAQLMPVIERETTTIISYPCYNNRNETRGNIYEIKVVGNIDNVLKARRYIMDLLPISMCFNIKNTDMAEPSRVSDRNIHMIIDESGIILKMTPSVYEPADLLSGEVPLNCASLRSKEFNIKKLYTAYQKVLSKKFDFIAPQPNDYDNSIWHHSLPANFLKNFNMPCRGELSDGSNGRRHRSSSIASSRSKHSYMSKGKQFSESSGGPSRSHTRVSSFSENSSTVPIMQFPTPHFAPPMLTPHHHMLKYVYLQQHQQAQTFLKGAAGLHPGTHIMFPPPIIVDGSFVSALPFADPVVFDGFPYVHGLFPVNEAEQHRNHRESSPSLRSTQEIRKPSRNMGNRPSSSTGSYYPSTTPRQRVYEQVREDDLRSHIGSRRTSVNGDDQNVESMHDQGYERQYPRQHQRLQKDDQQRWKTGSRGDIHSSRTINVHRDVRNSNEYDFHVGNSGPAKRSPSLEQVQLQMTHHLKLKSNDVDLDHEKLYMHESPHNDSDTTVSASGFGNDLMDGDFVQRFLSNANINESGRRPRTVSCFTEKDGQSARYIDSDGAYSVVDHASTHQSRSYDSFRKVGDNGVTKTILEPRARVEKDYGKISLEHKTKYSNEYGDEEKSAENDTSSLGSRQYRIDPMKLIASVRESSEQLPRIHERQFSDVLNEKEKEIADKSIESTVTQDLSLDETSTY
The following text describes a protein:
Function:
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRLPRQSPYEILLLVLVALLVLLLLLTSKSPPSCSAPERSKEPEDNPGWATGHPRTHPARCRANLSVSSHPDFAGLPLHVRDFLFYRHCRDFPVLREPRVTKCAEPVFLLLAIKSSPANYGRRQMLRTTWARERRVRGAPLRRLFLVGSDRDPQQARKYNRLLELEAQKYGDILQWDFHDSFFNLTLKQVLFLEWQLTYCTNASFVLNGDDDVFAHTDNMVTYLQDHDPDQHLFVGHLIQNVGPIRVPWSKYFIPALVMAEDRYPPYCGGGGFLLSRFTVAALRRAARVLPMFPIDDVFLGMCLQQQGLAPGTHSGVRTAGVFPPSPRVSSFDPCFYRDLLLVHRFLPFEMLLMWDALNQPQLLCGRQSPAY
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MPTNVESPPCKKSNVEVMTPHRLTVAILIRDYCLFRDSDRFSCEDDGVLKARYRRDFCVLILKLLQSPDLSLEELRNILVSTKYEVHQSVIEAFDETLASLYTNGTGTMLDIIDSFNRIMTFNENIAAGIEPNCFVSKSSIVGYYLRRLIVNFDKLTFSEVTSVYLTFKRYYEDWQKSLTTRDQIAIEVNKVICPDDWSANRNQWSRRQAELFIATQAALLTNNEEKALPPQELHNRISNLLQSNRSLAEAHFLSYLNYLRVKEFCGAIDSLYHCFDRSTLTDTKISSEDKSKVYRFAALNLAILHHHFGHKEEALASLREAIKSSQVANDNVCLQHALCWLYRLTPVNKEKLLEHSVAKSFELNLSYTASLGIQTFVQYACLISGHPHQIFETLTKGDLINCQHILRDLISNSYAVKSALWQFYGKTEMSSLWSQLLFYLNIDNGRSNDGKAVYGEGFCLAICNVANHLLMQGNYNLVNTVLNFAKDRFPNEPNSHIWMLCENLFIFVRALHHENWSEAEAAAQKILVVDKWEGYLRLAELYYYKQDYTEAHRFVDILINRFHSDNKYKLKIFYYVRAKILLAEIQFSSCYPDKVSPEIMTLLSNCLLDTDKHNLDYHSALIHLHIANIQLSLGMTSQALKILDRCLVQILAHGGNFDRARAVLLYVKCLVAHSAQLEATERREIILNAAQMLEKVKEDFRAVEAYSRVKDVLYLQAQLYNSVDLRSERNRCALEFRQLDEERTTKNYYTLVRFL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MQLHPVSASLSGLTLSAYSEDDIRKLATCRVVTEQGLDNVGLPIRGGYYDPAMGPRLFYDVCETCGLRWKHCPGHAGYVELPVYCYNHFFFRYTLQLYKLVCHSCHRFLITELQALTIETGLLLLDAGLVCDMHQIFSILRGTSHTSLALTLAKLRQKAYDYLSHSRPVQYTSSIIMLRNQLQTFLLQLKPPAACPHCASPFTQAVKRSAFNIYLIPPKTRQLRSSSRKQKKQVPAETKPVAQGQDSTEDKEISKPDKQVVLSDMLYCTPIMVLRELNAAVAKNQHLFDLLFGEPIYHSSEASADRAGATTPNYDPDYAFMRSVAIKNIIGDAGCELSFPQYRKKFLPSTLFIKTLLVPPNRQRPSLMLNQAFIDHPMNTHLLAILTICNTIEQLRSSPELAEFVSKHALDDINVRASHVPSSVTDGIDELGGIGMFRTDRYNFVKDPELLANGMVELSTSQKPVPEALVEAMLILQLHVSRYLDGTVLSKTIFSSGIKQLLEKKEGLFRMNIMGKRGNYAGRSVIAPDANLDTDEIGLPEYFAKKLTFPEPINEYNVELMARLIINGPTYPGASLLIDESGSRVLLTQLSYEQRKALAHTLLVDFSREPVAPTVEESEEVQAALDTNPALQNMRSYDLRGMKTSFADTLKPPKILLRHTLPNDFVILNRQPTLHKHSMIALRVRVLPSNAQTLRFHFASCKGLNADFDGDECCVLKPQTHEAASEYANLVHADAHFISVTSGEPIRGLIQDHVIGGIFLCSMGTFLDFGSLCEYIMVATGSNKLSSFEQSSLQSRSKEQLLGLDLISKQTTTENVFGSLSDMKYMGVAKNKTVMRAKSDVNIALGRKYGASKLQSERPIDVGSLVSSAQPVSRHPASFFEDYPLSDATSVPQLTDMGAYDGFHTHLTPAIKPSARSEEVNAFSTCKVTVIPDQHLFTKENEDFMFVPQPAIVYPVARWTGKAVISSMLHKVSCQREPINYTGSIKIPTDIWGPFRETEARLVIINNTLLTGIVDKQHIATVPHGLAHAVFELYGHNRCGWFLSNFGRLATYVLQRHGFTCSVEDMVLRDTAEKARYKLCDDVLASGAIRTAEFLCEYLTLTGLLGNLEASDASFLMKFAEKGSVGLKALSEKDRLRIYSILRDSLSLDTTIEARLDNHISNEANLITTNLMKICSPSNLTLKMRSSISGNNPYGTPRIVTPSRAYLCSRNMASQKSINCLAYMVLSGAKGSTVNLQMMTTCLGQQNLEGRRVPSTQTGKTLPSHIPYEHCELVQGGYVIDRFLTGIRPSSFFFHCQAGREGLIDTAIKTASSGYFQRVLVKNLEGLVVAYDGTVRRSDNMLVQLLYGGDGVDTTKTSYLQEFEFMYQNQKLYIDRFIPDMFYDGRYLSDSEAVTSLAKQVRHDMKHGKQPTDKWQALRGLYERYTGASLRTSFENLIHNSNRLASALRERHEVHNSNLARSHNLISTLNSKACELVEKYVTLYKKGLDEANLVTETHILQPTNKERDKLVKYLKAIYLPETSKHNKDTLFDHMTIQDLAEMYTAFQEIPIHMILSPYLYLGSTSPSFSKALNEYISQKQSEKQTQAMGGLSFDSAYFKLLAYTKFIRSLVAPGSAVGVIAAQSTGEPSTQLTLNTFHLAGHGGVNATMGVPRLREIIMTRNTSSPIITMSFKDKHRVSVLKGDSLHHKTVSLGPNETMRACKSLQQQLRKIYLRDVLRSFVLRECPISDGSVRYELTMKLLTLSELLHEFNFNVVVLKKLFAVAIPKHLARVLTKEVLAHKATIQSLQNKLPSDTSFPEYVEKVAGPRNSTGKEDSDAQEDTSKENSSVSNPTDSEPNLDTDASDTTDSTQHAQEQHDTEESALHAETDPSLNDIDQHRGHEALSLIDSNINLSAKAKDFLKEWVFPDIDKLIEVAQKAVNTTCITLKRISFTLEDTALGVSPDQLPLSVTIQFVNSDPSHVIALATIEKAIRSLVLKEVRGITRCFIRYELPADRYVMDIEGGNLRALFYLSNPFINFDNIYTNNISQIFEIYGIEAARNAIIEEIHRVFSTYHIEVDERHLSLIADSMTLSGCVRGLNRLEMRHQTEELLKASFESACTSLAAGALTSGFDSLRAPAGAVTVGQYPSQGTGSFDLLTQL
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSFAFGSSGTSFNSGVSFSYITGVPDTKAVTPPARTVLFKNLLKRDASTREKAISELLTQLQAKNPETLDKTTYYAWIQLYAKLAIDISRVVRDKAHRCQGYICSILGPQSVPHLGDAICPWLLGTVDSDRQVAMAAMQSLDIAFPDPEKRGKFLKTFRKSCVTTLVEALRTETKDSLSDDRFVTKEEADAKFNRFRSSGIALLGNLLPFKQSELDEGCEDILHDDKLWNSVTSDDSALAQAVITLASKMITDDSLHETFSNTLLRKGLGSINPGCISTYTKLITKLTVTNPEIWSMAKKPLTPQLSKYLRTSKAWNEIPVLIEAINRTSLATDMDKLMADFLSGVTSDESPGAWICFFDTIAKIANTSQLGAALSQLGKLKEIIRPRGLCNATLTPTGQMYPYVSNLARACHSEFETAYNAAITRTTEKKDFLTFEKLMQLTAFLMEDEPLRPILGPGIEAIFTFPVEKATKALLYPVNKFHLLSESLQNKFIEFTMALPLHFTADNVGLLLDLAQDMARKMPAEDVDKFFAITTDNIAKVEDTETRQNLLHAFVSSHWPTTLPDSVVTLLEGTLDHSSTALLLKGSFTDEQKKALFSHFEDDLLGDPTALEDLSDGVLTRLCDGFLVDNRSILFEDVMFEPFIEKLLGKIEELEYTNKELASKLAEQCVKAGLKDYLLSSGVRDFIADLSKRVAVPWLFEACQLFLTKLQNLLQYDLSPSLTVTSKFGGAVLFEQFVGPDELAGVKPEPRLIDEALGLFGFMFTLDKIKPVDDTLVEYVTVAKKYTELNSVTTDFDFDRYAAFASMNALSNDLKTKFEDNSKLNGPAAFYYAQIVADTTVPVGTVNVRKLVQEEKYTEALIDIVSRSEEDFQQTLSYLASEIPSVSALEIEAKSGFNRLVLINCIFECSEYELDIPLQRLSMMTNTLFDWCLEAENAFELDFIPIRAEIAKLILHLEDQDVSRDLYEKFLSFVIEGLNILSSLDKDTIDGDIAEIVDGFRLQLFKILATYFNNKETNPVLAEVWKEEIDSVWEDLAGHFCTYVTSPSPLAVKVDRLLGRIAVHVPIKYFELDKLFGVVARSSPDCQFAATKLALKMIPDQQEELSINVELAKTKVASEHDDEDHNIDVTLSPELRSVVESAEPGSSRFLLAWILILDHLDASSYAIKQVYLDQLKSSDAVNDMLTCISEMVQTNPSTKNHTAFPKTLDLSVLAAHLYYRALVHLGSITRLWFADIKKRSVALAVKETTKKHFSPQLIEDEMERVEELLNKASLDDSMSVRFNKQTHEVRATYLVDEQKMEISIVIPDDYPLSAVTVEGAVRVGVRENKWRAWLLASQAIVANKNGTIVDALELFKKNISLHFSGVTECAICYSILHQDKSLPSKTCGTCKNKFHSDCLYKWFKSSNSSTCPLCRSTFSFRVGK
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate (By similarity).
Sequence:
MARLDYDALNATLRYLMFSVFSVSPGALGDQRDAIIDDASTFFKQQEERGVVVRGLYDVAGLRADADFMVWTHAERVEALQATYADFRRTTTLGRACTPVWSGVGLHRPAEFNKSHIPAFLAGEEPGAYICVYPFVRSYEWYLLPDEERRRMLAEHGMAARGYKDVRANTVPAFALGDYEWILAFEAPELDRIVDLMRELRATDARRHTRAETPFFTGPRVPVEQLVHSLP
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MQPQWNSCPQSNMPISSPGMQPRYANHARNLTSPVLFSTSDNLDAYSNDTRGQTLVHDTIEAEISTDDDFSGTEDLLESSEASSEENSEGQSDFDLPSNRPGTDVVLEPDYLSALSFIDDGLLQKQKFPQDEISCSAEYVSCKSCRRMEISSTDVSNSERAACDSSLPYRSGEQSTLQDLDNRITNSCHNTCCLSDCFPGNLLNIDRRSSQSTWSHEVEIEPEVGSCKFGVQLPNNVDSSGSVLPRNPSLPEAYEKDQHPYRACTFLSSTSLPSWKLKHNSDFLSMNPILARSSLVNPKREPEQMFSRDSRQSFPFFNFTSIRDPCEVYIEKFAANSRDQLGAGVSVLTGTAATAAVLTSCQHNLKDHSDKNLEKKEELSHTCSPVGSEAHIQKISSLENAAGGSGWERLLANSSKIASTTARFPKTSLVTVLEMPLDHIIKKCLLEEILLQYKYLSKLTIQLLDKGFSLHEHLLALRRYHFMELADWAHLFVSSLQHHKWYTVEAEKRISAIQGILELSVQRSSCEGDPYKDRLFVYVKGSMTNISVSGRGTFYGIHSFDCLGLGYRVDWPLSIILSPGALKMYSDIFSFLIQVKLAAFSLSDIWRSLKDLSKLDKKNQHFAFGNAEPKQLSILIETSNMYNHNYLMCPGADSCILLRIRFGAPSDLGFNEFHLFPLYLLFGL
The following text describes a protein:
Function:
Molecular chaperone that binds nascent RNA polymerase III transcripts, stabilizing these RNAs against exonucleases. Required for the 3' endonucleolytic cleavage that matures tRNA precursors and for efficient folding of certain pre-tRNAs. Cooperates with GCD14 in the maturation of a subset of RNA polymerase III transcripts. Functions also in the assembly of certain RNA polymerase II-transcribed RNAs into RNPs. Binds and stabilizes newly synthesized U6 snRNA as well as precursors of U3 snRNA from degradation. Facilitates efficient Sm protein binding, thus assisting formation of the U4/U6 snRNP. Required for Ty3 normal transposition frequency.
Subcellular Localization:
Nucleus. Note=Imported into nucleus by the nuclear transport factor SXM1.
Sequence:
MSEKPQQEEQEKPQSRRNSFAVIEFTPEVLDRCLKQVEFYFSEFNFPYDRFLRTTAEKNDGWVPISTIATFNRMKKYRPVDKVIEALRSSEILEVSADGENVKRRVPLDLTAARNARIEQNQRTLAVMNFPHEDVEASQIPELQENLEAFFKKLGEINQVRLRRDHRNKKFNGTVLVEFKTIPECEAFLKSYSNDDESNEILSYEGKKLSVLTKKQFDLQREASKSKNFSGRSRSFNGHKKKNLPKFPKNKKKNGKEESKEDSSAIADDDEEHKE
The following text describes a protein:
Function:
Involved in pre-25S rRNA processing.
Miscellaneous:
MISCELLANEOUS: Present with 5910 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSAIDNLFGNIDEKKIESSVDKLFSSSCGPINKLEVKSKTRTVLPDSKKRERAAEADQEEKEASKPDVSDEQTEEVALPKVKKAKKSKRNDEDEDLEARYYAKLLNEEAEAEDDKPTVTKTDETSVPLTSAAKKVDFKEDELEKAERTVFIGNILSTVITSKKVYKEFKKLFGTNPIAETEESGNEKEEESSKKSDNNEFAIESIRFRSISFDEALPRKVAFVQQKFHKSRDTINAYIVYKNKSAVRKICSNLNAVVFQDHHLRVDSVAHPAPHDKKRSIFVGNLDFEEIEESLWKHFEPCGDIEYVRIIRDSKTNMGKGFAYVQFKDLQSVNKALLLNEKPMKSQKQEDENTKKPTKKARKLRVSRCKNMKKGTTIGTGLDRNGLTDSQRTRAGRAKKILGKADRATLGQEITIEGLRAKKGEGSTHLKKKKQRSATGRVTKRSIAFKKAQAEKSKK
The following text describes a protein:
Function:
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (By similarity). PatO acts with patJ in the vacuole to convert gentisyl alcohol to isoepoxydon (By similarity). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable).
Subcellular Localization:
Vacuole lumen.
Sequence:
MRLSIYSSILLLRAMCLVRPTFGFPATTCRCMPGDSCWPSSTDWAHFNASIGGRLIATQPLAQACHDPYYNETECQYLQKHWTLPALHDISPSSIMAAAVAKDTCDAFTPRSKPCAPGDMVVYSVNASSPDDFSRTIRFSQQRNIRLVIRNTGHDYLGKSTGAGALSIWTHYLKDIEFVNYTSSSYTGPAFTMAAGVQGSDIYNVANGRGLVVVGGECASVGPVGGYTQGGGHSALSSRFGLAADQVLEWQVVDGTGRLLTASPTQNPDLYWALSGGGGGTYGVVYSMTVKAFPDFPVTGVVLQFDTKNTSSKDFFQAVSYYHRDLPTYTAAGGMAIAQITRSSFLLTPLTLPNKTTEEARSLIAPFIHELETLHIPYQLNITQSATYLEHYKKLIEPNPTQLVQNGQYGGRLLPLNVIESNNTQLTEAVKTITQDGVVFVGIGLNVSSSVVGDVWNSVLPAWRTAALSVLLSTDWPAGANRSTMKTLADRMTSKWVPILTALSPDSGCYMNEADPQQPDWPQTFYGRNYETLYAIKKRYDPFDTFYASTAVGSGDWQVKTDGRLCRVKGNT
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Sequence:
MAIDEQKPVYELQKELDALREDYLAGMSPEHAATLQRTATELVLSGIVGHAATIGDRAQDFTLPNAVGRQIRLSEVTAQSTAVVTFYRGAWUPYCSLQLRAYQAVLPRLRELGGELLAISPQTPDKSQATLLKNFLQYEVLSDVGNLVARSFGLVYPLGEEMRRIYLGFGVNLADYNGDESWELPLPGTFVIDGTMTIRYSFVDADYTRRLEPATILDVLERIREERGRDDNQAS