lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MSKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVKLNKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIASREDEIKNFKAQTYYGIEAQTMEKLKLTWQDANGNSRSFNKEKIDGIVKRLDKQNATVVEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPFAHKVLQKPIKPNKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPHIEKGDTLAVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGNKADKRDVQKYMKQQNKEEEPLNNPFAEALKKLKFD
The following text describes a protein:
Function:
[Venom peptide 2-long]: Antimicrobial peptide with strong activity against the fungus B.cinerea (MIC=0.5 ug/ml), and poor activities against the fungus C.albicans (MIC=100 ug/ml), the Gram-positive bacterium S.aureus (MIC=125 ug/ml) and the Gram-negative bacterium E.coli (MIC=125 ug/ml); [Orancis-protonectin]: Antimicrobial peptide with strong activity against the fungus B.cinerea (MIC=0.4 uM), and poor activities against the fungus C.albicans (MIC=16 uM), the Gram-positive bacterium S.aureus (MIC=20 uM) and the Gram-negative bacterium E.coli (MIC=79 uM). Shows cytolytic activity against insect cell lines. Has potent hemolytic activity against ovine erythrocytes. Has potent hemolytic activity against human erythrocytes (EC(50)=31 uM). In vivo, peptide injection in the vicinity of the head and thorax of lepidopteran larvae induces feeding disorder followed by death due to starvation.
Subcellular Localization:
Secreted. Target cell membrane. Note=Has an amphipathic alpha-helical conformation.
Sequence:
MKQSIIIALFATIAVMACLQMVAAVPAPVPEAAPGPVAEAEAYASPEALASPEAEPILGIITSLLKSLGKK
The following text describes a protein:
Function:
Polyglycylase which modifies tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of tubulin. Polyglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin.
Subcellular Localization:
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Note=Mainly present in oral cilia.
Sequence:
MFSIDIQGKSMSLCDPTSKIKQMQQQQQQLQQGTNNGIQKDQQLPNMIINGNSNSYLNNGSNLQQQAVIQQSNHKQSQIKYNSPLSHQQHHQFKIGHQNKLEYLRQQQAQKYNQIYQLDPQLQQQNQMFQQHQYMQNVQMQQQLLYQGNQEVFPPFNQIANGSAQNSILLQQYLSNNKGQTNNSNRENGGNFHSEQSPKSAAGSVVSGNGSNTQFAANILRNSNIIQQQNEFRFQQIQQTHQLLHSLVQQQPQPLSQQHSNQSSQSSNPQSQSPLPLSISSQQPVISMANYFNQPSQQSNSLFNGQQPTMFNSSENFQQKNILYSCVGNPNNPYNHHINNPYLQEKRYYKSSKLPKIKKENKPQQAFSDIRPSSREKSARFHLAASINTILNQNGSTSVNTQNNENMVQTLKGHSYSAVTEKSNIGQQEVNIPTTSKTQTLIKEHSLTNINSASKENNQVTLASNSNQTSKKAYENLMSAENDEEDKLKCIRYFRYNLGQLLHILGKKEIYFSNLNSKKPIKTFASITQQLGQKHMNLLSKNTINIINKVKKIVATKGKYKYRERFNFLHSAQLKSINYDVRKRLNQIQDKKVLSNTKSKDEEESSDDDETPVKSKSNNQNAVQQTDLAKWKKYNRLDPKTKVFIIKGGYGDLRKALQERGWVENPDYFSPCFDLKWTCKVQDIDYDNLQENQVVNHFDNNQTFTSKYGLARNLRTLIHSENIDVYKFFPRCFDLGDLQEFEDFIENFKVAKAESLVHRFKDMLKNGIESIDDKLELKIRLCNEVASRKFIDFYETVDFIFNYDVLPCVSPEEWEIISKDEFQLDNKKIEFYLERLRSHPTFKHLYYSNSQSQKQHMNKRKNSHRISVNHNHNDPIEEESAQSSTSLKQDSLQRFSSKSQELLDLCNQTLKKSSEKDPQHHLNGYRNIWIVKPNFLSRGRGIKCFNSLDKIMDYVVGKETQFVVQKYIENPLLINNKKFDMRQWAIVQDFCPPRIWFFEECYIRLCSVEHNIDDLNNRFVHLTNNIVQKYNKDAYADKDDLMMSQEQFAQYLKETEGRDVFYEEIQPKLKQMVIQSLKSCQDQVGARKNSMEFIGYDFMIDSNYQPWLIEINSSPSMEYSTSITEELVQRVLQDTTKVIVDYSMAKKGTKKNVDTGGFKLIYKGEKQTKNNKVLASYKK
The following text describes a protein:
Function:
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Sequence:
MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDIGDAVVGGNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSLSGKSCQLYRHDLVALHSKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMIITPELEYPIVCTGVRKAMNGCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY
The following text describes a protein:
Function:
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor.
Domain:
The CRIB domain mediates interaction with CDC42.
Sequence:
MSEFWHKLGCCVVEKPQPKKKRRRIDRTMIGEPMNFVHLTHIGSGEMGAGDGLAMTGAVQEQMRSKGNRDRPWSNSRGL
The following text describes a protein:
Function:
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytoskeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity).
Subcellular Localization:
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis (By similarity).
Sequence:
MDRVTRYPIFSNPRSARVTSLVLDEDTSYTVELVGVGPEAGWSQGDLQAWSTEYQTRPDVKRTNVSSNRRVFLGQQSPRSLYLEDEDEEIKSYHLDDSSDTLCRQRRELEAERWAVIQSQAVRKGGTVATLQAASDHGDLRIARQPQSTVTEEILVDTEQIDFLAARQQFLSLEKANTNPVPCGLTARETFPRTPPGINQAPKASTGPHLANGYTTAVTSPMKEVTLEKSFHVSPARSIHIVNDPGSQTQAESPETPKETPIEREIRLAQEREAELREQRGLGRAAGHQELVQIPSRPLLSKMSLTETPPRRDRGRPSLYVQRDMVQETQREEDHRREGLQVGRASTPDWPSQDPQPGLQRSLSSDCILSPDARATDPAPEARKVNRIPLDAYQPYLGPGTPKLEFSAFGVYSKPSGVSTEDTKATVFQKATESPRHVSESSGRSLSSKQEWSKPPGKATNVGVVRLGNFHLRPLRFKVPDVPQGTETPHTWGWEVAGGPILRLQKSQSSDLLEREMESVLRREREVAEERRNAFFPEVFSPVPAEDESHEQDSRSSSRASGITGSYSVSESPLFTPVHLNSGLVWKVEAPEDSAPPGQKTRKEMWYAGINPSDSVNSEVLGATRVKRHKNLLAERWEAHIYASEDEN
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSGSAEHLKDEGSKTQSMIAGATAGLIARFVIAPLDVVKIRLQLQSHSASDPLSHRDLRGSLIYKGTLPTIKRIFREEGLSALWKGNVPAELMYVSYSAIQFTTYRSVTLALQDTVGEHRMPAAAESFIAGASAGAVATTATYPLDLLRTRFAAQGVERIYTSLRASIRDIAVNEGPRGFFQGLGAGVGQIIPYMGIFFATYETLRVPLGTLHMPFGSGDATAGVLASVIAKTGIFPFDLIRKRLQVQGPTRERYVHKNIPVYNGVFRTMRHIIQNEGYRGLYRGLTVSLFKAAPASAVTMWTYERVLRLLLKWEKAQESPT
The following text describes a protein:
Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Sequence:
MFHSRALKLSSQIANNSPRKFSTSTIRTGSHQLLKNLPYERSKIYSVIVDVQSYPEFIPYCLSTRIIEPVTQLDQKKENHKEQDSQSTRSNLINHQFEVFTRIGYKGFETDYHSQVICEPFESVRVIAKPSSTFTNLTTTWTLSDPPCSSTSSTTTSNSKPVTQVGLDLSFKFKNPIHEYLLTDQAIWKKFSTLIIKSFEDRLASLN
The following text describes a protein:
Function:
Transcriptional activator that functions by regulating chromatin structure. Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors. Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones. Involved in zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization. Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3'. Binds DNA as an oligomer. May also act as a transcriptional repressor, maintaining the repressed state of genes including lolal, and down-regulating its own transcription. Required for dosage compensation in males and may be involved in oogenesis. Also has a role in nuclear division.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The N-terminal BTB domain mediates protein oligomerization. The C-terminal glutamine-rich region is required for transcriptional activation activity.
Sequence:
MSLPMNSLYSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAPQTVTKDDYTTHSIQLQHMIPQHHDQDQLIATIATAPQQTVHAQVVEDIHHQGQILQATTQTNAAGQQQTIVTTDAAKHDQAVIQAFLPARKRKPRVKKMSPTAPKISKVEGMDTIMGTPTSSHGSGSVQQVLGENGAEGQLLSSTPIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQGATGSSGGNTSGVLSTPKAKRAKHPPGTEKPRSRSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKPGVKKEKKTTSGKKSSSGSSGSGSGALSSSGSVPQVQTVQSLHTLQGVQVKKDPDAQQQQQQQQQQQQQQQQAMTVSGATGGQVQQQVQQVQQQVQQQQQQQQQQQQQLQHHQIIDSSGNITTATTSAQAAAAAQQQAAGQQQQLVAQSDGSESGAPLSIAQVQTLQGHQIIGNLNQVNMTDFQQQQPQQQQQQQQQQQQQQQQQQQTQQTL
The following text describes a protein:
Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Sequence:
MNHIKKKYKEMKNIKPFQVKSFIKIFLNCQIVNPAFDSQTKETLTTKAQKFGSTFEVSEKFLDEIIKKTEIIDNVILQAKSRLNKQLSKQLSAKKQQRLLGIDKLEDANDAGTKNADLCTLILTEGDSAKSLAMAGIEIVGRDRFGVFPLRGKLLNVRDASIQMIMKNAEIEQLVKIMGLQFNKNYENTKSLRYGSIMIMTDQDHDGHHIKGLIINFIEKFWPSLFKMKGFLKQFVTPIIKVTKGKEFHSFFSIGEYKKFIAENPREDYKVKYYKGLGTSTDSEAQQYFSNLTLHRKVFTYSDQTDSDYIDLVFSKTKADQRKDWLSEYSWKQVEDTLDYSKPNVRYRNFVTDCLAMHSISDNLRSIPSSIDGLKPTQRKIIHTLLNHSKQEYKVSSLSGLVTTYAQYHHGEQSLQQTVVAMAQNFTGSNNINLLLPIGQFGTRSMGGKDAAQARYISTKLSSLTTKLFNEDDLHTLNYLDEEGYTVEPFWFTPILPLVLINGAEGIGTGWSTQVPNFNPREICQQIKRKLRGEEFEELVPWYKGFTGSITAGTNQYIAKGSFIQHKNHLYITEIPPKKSVKEYQAFIQSKMEVAEGKSEPEILDMKEYHAGNKVCFELKVTDEVLKQDIEKYFKLQTTIAMTNLVLFNEKGLLKRYSNVSEILDEFYQTRIKFYQLRKEYLLSKYQNELELVQSKSKFIEGMIDNSIQLRGLKKMEMCKKLQSLGFKGISKMEKVKSTRISKDFDADNLEKQYDYLLSMPMWNFSEEKITAFKQQIKQLQDQITALNKKTPQQIWSEDLDEFLEELTKVEEQETQEMIKRVEKNAEKLLKGGANYLKAVVLKGKDDFAQQEDYDSESDGDGPSRDPKVLKKVIKEFANFGIKSQRDVPQSKFKLQIEKQAKKKDSKENQDDNKSEKPISMDLEDDSPKRNKKVVDSQSEDEIINVKKNTRRIQKQNDVEEVQVQTKDSKTNKVDTKPSKAESKLEKAESKVTKTNKSKRIVPQMDSEKKASEIKRKAEQEKAEEDQKLIEQEKEELEKQRVPVDSLKVPNQDKEEMDLFQKYGFGDFMKYLTPANGKDNNPIPSLADRIFQRTKQGEINFDQIIADKKQESALKERKDSDNEIEDFLQLDLSEDSDKKQKVAKANQKTTAERKSGKKSTEKQQQQMTATPAKRKQRKQIIESSDEEPLNKKPKKK
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MVGGKVCGIVSNVSVLSQNERLPFSSEVLEPLWTPSSNPSLHALKSMVNYENFSGGNTAAARPFFQRLDKDEHVDEDYDVGCFHQPGKKRRLTADQVELLERSFEVENKLAPERKIQLAKELSLKSRQVAIWFQNRRARFKSKQLEKDYDSLKACYDKLKVDYENLLKEKESLKIKVNSLKDKLLIRGKEMGNAEPLDVIKLLKSEPKETIRNPISENMSNVPKLVCKQEDVSSAKSDVFYSNSPRRTDGKNYSSLLAPADSCQVFEPDQSDFLHDEDDNRSQTLLPQPFFLKLEDGCHDPPANYCNFGFPAEDQPFCFWNI
The following text describes a protein:
Function:
Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth.
Subcellular Localization:
Cytoplasm. Note=Septum. Localizes to cell tips during interphase and the septum in mitotic cells.
Sequence:
MDYRHPNALGVNESSRAYEEIFGAPRKREPARTVSTPAFMEPAPVSKKPLPPPTRRLPRKPLPFRSTSLQPPSSQPPAPPTHQREASPVKNIEHSESFPSVFGTSNNHQIVPLTLKDGNDFGALYASLNTTPHFPQVSNHAPNNSNSPSLTWHTSSGDDSNQNPFFVRRQSQSSTSPVSDSVDENLLSAVSSVTESVETNLHLDQNYPYGSPVRSSKNPFLSSNSRLPTDDSSHTVGSHSFTSGTHPPIVSSNSAFTLPNAVTPAAQAPLIRSVSEYPANVSPPAQSLQLPKSTSNPADLHLSIASASSHKNIFSGLDVFSNVFHGPSTTLRDREHDMRNRSFDHSTLAHYEAVKQQRLGVEPTARSFTLSSYKSRASGNSLINDRSSTTTPTFVNSEASSPVHKNKRRRRIYAALLSRVASELLDRLQLGDITKDGLIYSNAFTGDHAVTVLMGIIHTSDRNLALLVGRSLDAQKFIHDVTYDHRLRDSHREIYQLQGTGYRPFLRANDNASINNKNHHKELEDNESGTRISPSTLGDTSFPNGIFTLLTHCYSPTCAKDHPCYSISCPRRLEQQHRLFAKMRANTEQSSSLAFDDKEQKLWIHSVPQEIAYSVSDRERKRQEVICEVIYTERDFVKDLEYLRDYWIKPLWASSCIPERKKEKFIRTVFLNALEVQAVNSKLAEALTKRQNYKPIVDNIADIFLEHVPKFEPFIRYGAGQLYGKYEFEKEKSSNPAFAKFVSDVERLKESRKLELNGYLTKPTTRLARYPLLLEAVLKYTDEGNPDKQDIPKVINIVRGFLSRLNVESGKAENKFNLFHLNQQLVFKPGEHYDLHLLDANRQLIFKGPLKKRSAGSTSSESASDVTLFLFDHALLIVKPKTINKRELLKVFQRPIPLLLLQLFLVDDNGLRIPYSSKQQLAAVSKAANGKPPSRFYPFSLQLLGRRGYEITLYATTEVSRDKWLEHIDNQQTLLQHRNQWFESVTICSNFFVGDNKVNAIGVYDSGRRLLYGTDTGVYVSLRKANSPLQFKPVRALNIPNISQLEVIEEYSLLLLLSDKVLYSYPLEMIDADTTQAPKKARKVSGHTTFFRVGICLGKVLVCAVKSSVLSATIKVFEPVTNYSKTRNMPSLKKFLTVNQDPLRIVKELYIPTESTSVHFLKNKLCVGCTRGFEVVSLDNLETQSLLDPADTSLEFVEKKENVKPIAIYRMNGGEFLLCYSQFAFYVNRDGWRSRPTWFVVWEGSPQNFALSYPYILAFEPTFIEIRHVETSELIHVISGRNIRLLADGRGKLGDGGEIFYACDQRGENCETSVVCSLRLTSAAAHAKEQHVDK
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity. Enables the organism to utilize D-amino acids as a source of nutrients (By similarity).
Subcellular Localization:
Peroxisome matrix.
Sequence:
MHSQKRVVVLGSGVIGLSSALILARKGYSVHILARDLPEDVSSQTFASPWAGANWTPFMTLTDGPRQAKWEESTFKKWVELVPTGHAMWLKGTRRFAQNEDGLLGHWYKDITPNYRPLPSSECPPGAIGVTYDTLSVHAPKYCQYLARELQKLGATFERRTVTSLEQAFDGADLVVNATGLGAKSIAGIDDQAAEPIRGQTVLVKSPCKRCTMDSSDPASPAYIIPRPGGEVICGGTYGVGDWDLSVNPETVQRILKHCLRLDPTISSDGTIEGIEVLRHNVGLRPARRGGPRVEAERIVLPLDRTKSPLSLGRGSARAAKEKEVTLVHAYGFSSAGYQQSWGAAEDVAQLVDEAFQRYHGAARESKL
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Miscellaneous:
MISCELLANEOUS: Present with 1254 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MDFTSDTTNSHDTSNSHLSLEDAVGTHHAGEADVNIDGDEKQQLSLLDDDQVRALKLQEEKDALLTRRNTLLQEIQTYQNILMKENNSKTKNGDILQNDITQDFLNLISISSSNPNSAISDRKRVERINGLTNLQKELVTKYDTLPLLNMNLRLSYLRDHTYPHLQVSVQSRDRVHNDGIEVLVVNYKFCRNTMNPFEIQFKMFYKFEDSTLLKWEILRISTNVRLKAKQLLATRNFQKCLLSLYEFDKIKSKKTGIFQNLINLLKRKTRCYLMNNSDSLIVERVIREGRLTTIKLQINFIITMPGERGKPRNCFLPMSKISIALWKGGERFNQIDLDEICYGLIKEYGVKTGLKEICNVCLFPDMYAR
The following text describes a protein:
Function:
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Subcellular Localization:
Cytoplasm.
Sequence:
MTHLFEGVGVALTTPFTNNKVNIEALKTHVNFLLENNAQAIIVNGTTAESPTLTTDEKERILKTVIDLVDKRVPVIAGTGTNDTEKSIQASIQAKALGADAIMLITPYYNKTNQRGLVKHFEAIADAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIVALKDATNDFEYLEEVKKRIDTNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTLLSALSVDINPIPIKALTSYLGFGNYELRLPLVSLEDTDTKVLRETYDTFKAGENE
The following text describes a protein:
Function:
Viral movemement protein which is responsible for cell-to cell spread of viral genome. Increases the size exclusion limit (SEL) of plasmodesmata by forming tubules structures, thereby allowing viral ribonucleocapsids to spread directly to neighboring cells.
Subcellular Localization:
Host cell junction, host plasmodesma. Note=Colocalizes with viral nucleocapsid aggregates in host cytoplasm.
Sequence:
MLTLFGNKRPSKSAGKDEGPLVSLAKHNGSVEVSKPWSSSDEKLALTKAMDASKGKILLNIEGTSSFGTYESDSIIESEGYDLSARMIVDTNHHISNWKNDLFVGNGKQNANKVIKICPTWDSRKQYMMISRIVIWVCPTIPNPTGKLVVALIDPNMPSGKQVILKGQGTITDPICFVFYLNWSIPKMNNTPENCCQLHLMCSQEYKKGVSFGSVMYSWTKEFGDSPRADKDKCMVIPLNRAIRARSQAFIEACKLIIPKCNSEKQIKKQLKELSSNLERSVEEEEEGISDSVAQLSFDEI
The following text describes a protein:
Function:
Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid.
Sequence:
MLVFIDDGSTNIKLQWQESDGTIKQHISPNSFKREWAVSFGDKKVFNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPLTEYYDRNNQPNTENIERKKANFRKKITLNGGDTFTIKDVKVMPESIPAGYEVLQELDELDSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLADDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGGGAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN
The following text describes a protein:
Function:
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKGGNYTSLGTCSGINVSGNVAGTRKMSLGKSIKMYLTIFILTTCIYMALYQYHISREPFAASEVVKHQEKSSSYIASYLWSPISLLMANSSSNTNNNSTTTSTTTTTAPTTPTTTTTTTVGSVGQKLGASSISSIRMVSLAATIPSFKSTLSESRSVSLGGHQKTATVKTSTTITTRTTASGLATTKLSATTRTTAKTSAKLSAATTPTASHMENGYKTRPTFVAASLPPPLYIITPTYRRPEQLAELTRLGYTLKHVVNLLWLVIEDANKTNPLVGHTLDRIGVPYEYMVAPMPEKYKQTKKAKPRGVSNRNRGLEYLREHATEGVLYFADDDNTYDISIFEQMRYISKVAMWPVGLVTKTGVSSPIIQAGKLVGYYDGWIGGRKYPVDMAGFAVSVKFLKERPNAQMPFKPGYEEDGFLRSLAPLDDAEIELLADECRDILTWHTQTKKNAPAQALNRTRYKNTNLEHIDRLLVRP
The following text describes a protein:
Function:
Brassinosteroids (BR) acyltransferase with acyl-CoA ligase activity toward brassinolide (BL), castasterone (CS), typhasterol (TY), 6-deoxotyphasterol (6-deoxoTY), and 6-deoxocastasterone (6-deoxoCS) and thus converts them to corresponding lauroyl esters. Regulates BR homeostasis and promotes BR-mediated cell growth regulation. Involved in vascular bundle development.
Subcellular Localization:
Endoplasmic reticulum. Nucleus. Note=Localizes in the endoplasmic reticulum in young tissues and the phloem of vascular bundles.
Sequence:
MPMLMATRIDIIQKLNVYPRFQNHDKKKLITLSNLDRQCPLLMYSVFFYKNTTTRDFDSVFSNLKLGLEETMSVWYPAAGRLGLDGGGCKLNIRCNDGGAVMVEAVATGVKLSELGDLTQYNEFYENLVYKPSLDGDFSVMPLVVAQVTRFACGGYSIGIGTSHSLFDGISAYEFIHAWASNSHIHNKSNSKITNKKEDVVIKPVHDRRNLLVNRDAVRETNAAAICHLYQLIKQAMMTYQEQNRNLELPDSGFVIKTFELNGDAIESMKKKSLEGFMCSSFEFLAAHLWKARTRALGLRRDAMVCLQFAVDIRKRTETPLPEGFSGNAYVLASVASTARELLEELTLESIVNKIREAKKSIDQGYINSYMEALGGSNDGNLPPLKELTLISDWTKMPFHNVGFGNGGEPADYMAPLCPPVPQVAYFMKNPKDAKGVLVRIGLDPRDVNGFSNHFLDC
The following text describes a protein:
Function:
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MTIDRTYPIFTVRWLAIHGLAVPTVFFLGSISAMQFIQR
The following text describes a protein:
Function:
Binds ATP/ADP in vitro. Possesses low ATPase activity but high affinity for microtubules.
Sequence:
MGAIGGDEVVQWDKMDGGEVVNGGGGGGVGKLERILVSVRLRPLSDKEIARGDPSEWECINDTTIISRSTFPDRPSAPTAYSFDRVFRSDCDTNEVYKQGAKEVALSVVSGINSSIFAYGQTSSGKTYTMTGITEYTVADIYDYIGKHEERAFVLKFSAIEIYNEVVRDLLSAENTPLRLWDDAEKGTYVENLTEVVLRDWNHLKELISVCEAQRKTGETYLNENSSRSHQILKLTIESSAREFLGKDKSTTLVASVNFVDLAGSERASQALSAGARLKEGCHINRSLLTLGTVIRKLSKVRNGHIPYRDSKLTRILQPSLGGNARTAIICTMSPARSHMEQSRNTLLFASCAKEVVTNAQVNVVMSDKALVKQLQKELARLESELRCPASYSSLESLVKEKDNQIRKMEKEIKELKLQRDLAQSRLQDLLQVVGDNHVHVSKQSSVSGRNFTFDVPQTCEDEQSTTESSEVVDSVQNFRFQGRRVAQREHKPQQAENNVQFTTPSRYSVSSPPFSGMLPTNRSDHLSQISNEDSDDICKEVRCIETNETGGNECLESSAVGSNSLQDPNAGSSMHINNDSNSSMNSRLRDESPVTLEQHLENVRKPFANIVKDLGSSTRNSSSSKVLGRSRSCRSLTGSSLFEDLEKDDCTPPNRSFIDFAGRPQNCQRRGSALNYDAESETLSRAGSMLSEITTTRDGLKANSSVAGDTEFTGIGEFVAELKEMAQVQYQKQLGHSGNGDLAEGTIRSVGLDPITDALQSPSRWPLEFEKKQQEIIDFWHACNVSLVHRTYFFLLFKGDPADSIYMEVELRRLSFLKDTYSNGAIASIPNTSLVSSAKKLQREREMLCRQMQRRLSIEERESMYTKWGVSLASKRRRLQVARCLWTETKDLEHVRESASLVARLIGLLEPGKALREMFGLSFAPQQFTRRSYNSWRYGRSSLN
The following text describes a protein:
Function:
Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (By similarity). Involved in collagen secretion.
Sequence:
MSSVSPSPLIALISSECSQKHAHNRGFKSLSHFIFPFTSHECQVREPIDNLKASQRIRLDIRDISSDGHLLTLSVLPYVLIQALKTCTDVSQSIKLFRDVLARCSEPSEHESFGHYLACIFVVSTEDENPLGEFSKMIQTQQTLYNTTSTLMIPGHCSTPKWAAPHAKTPRHYILLHDSRSPRSSTERRDELLAQMCATYGNDNCQMLQLDSDSESAEMKGVWDEIDEFNDVLEKGLEEAHQHSTDAIAPGPNGASNQQSPSSPTSSVATISSTMPAVGSVSPNSHPNSTVVWKSSKKLASLADAKAVQAILSKFLDVCLIPYVEKEMRFLYETAGQKKGIGKSFTSMKRWFGSGTALSNMATPITYAWDSSEMQTRRLADLLLMFGFPNSAFEQYRGLKRDLEADKAMAAHAVALEMCCVALHSAQPQLNANQFMIKYLETPVSLLIEHAKFRRYPSILRCAFNIADIYSDLGLHKEAALNLAKVSSIEGDHLVAVAQTLAAEQFEKAGMGRKASFHRVLAANRFSNAAIPALSFDCYRLALPAFDKKHWGVLDEHLAVRLLEEGQKAGVMTTDIASECIRRLVAVCPKLSPSLQTERLRTIVNALDIYFPHRNEPVEMLTDIPKVEMETVKAIYGERPLWNEIDENEHQSVSSDGWITVERAAHHALFGASAPYRGMQLVSDEHSDNQKIRETPAGERFRVMVDLTNPLKIPIHLQNLRLSVSDIHNQSGIEGSEKSIPELGALEHLQLDPEETKTIELYVFPRVGCLKFRVDGLLFQLAVDQKDVEARVPLKCRGKRLNKTAKQQKSKIYTNDERLSATVAQKPWPLVEFRVIKSPHQWSYCDQAQRYQLEIENIGHENVMSMCLATNAFDRVAAGSIDENEHHQQFKMNLAANNAKVATFRFEEGSTSSTDSFLKIGEKKRIFFDVRSSDEPTGSTVAPKQSNTVILIAYRSSNGTMRQWRRVIDGERRRLIALTAEILDLDTKSFSIHLKNCVAVSQAALSRVEILRIRTDRNEASTGIKNDCSTTVLPSVNRRVEIESEQTDTIVARLVPLSQGETIKESWLTTTTSVTPPKWPCPAEIHSTMDDEFASKIAEKIGILWKANIVNNEGLVTSFIGESFIDDPFVKLKTLKKDDSVLSSLRISCETTAKEISHNFSASHICELPITLLIQNKDLQRRPVSVSIKLSSKVREPVDGIHLVAPENRHQMWIDRPVRKQTIGIDDEAKLEMKWKITHAAVYDVGGANLSIEAIFEGSNDAVIFKVPSVLSVVKSSSYTVV
The following text describes a protein:
Function:
Required to initiate and then maintain lateralized gene expression in the ASE sensory neurons. Involved in determining cell fate in the ASE neurons.
Subcellular Localization:
Nucleus.
Sequence:
MEIDDCVIDMIQVFSKINREVPEKAKKAIVEIERLDILAKKEMEVAKKHKIEFFANYEEMTAEQKTKAFTFMQKKMAKVSEYSDQKIEIASGLKVLLKDVYGKFMEEEQKFIENLNKIPKAPETPPSSSPSVRSHRKKKLSEGDDDAPSSVDEKKRGRKKKPESEKAVAAAEPPKMYCWCQLDKNDTMIECENPGCKYGWFHFTCIGMITAPAGDWYCTNECRAQGLAAVAEAPQKAPQRKGLKKKK