lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release. In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung. Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense.
Subcellular Localization:
Secreted.
Sequence:
MSPGRASSVSLMLLLLLSLAATVKAAAIIPQSSACPNTEAKDFLQNVKVNLKVFNSLGAKVSSRRPSDYLNRSTSPWTLHRNEDPDRYPSVIWEAQCRHQRCVNAEGKLDHHMNSVLIQQEILVLKREPESCPFTFRVEKMLVGVGCTCVASIVRQAA
The following text describes a protein:
Function:
Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.
Subcellular Localization:
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.
Sequence:
MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARPVGCKWENPPHCLEITPPSSEKLVSVLRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVFGDGPYSTFLTSSPIRSRSPPA
The following text describes a protein:
Function:
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKGEEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKEKKKDGEKEDSKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGLGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCEEEEEEENDGETPKSSHEKS
The following text describes a protein:
Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MAPGWPRPLPQLLVLGFGLVLIHATAGEQAPGNAPCSSGSSWSADLDKCMDCASCPARPHSDFCLGFSWSGDDAAGEKSLLPP
The following text describes a protein:
Function:
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, tight junction.
Sequence:
MFDKQHYDSPPVYSPPFTPPSNNGFGPPGSFHGNQSDFNAYPPPPGSYYIEDRPQHFYKWRSPPGIVKAMMATVIIMCVGIFACVASTLMWDYQYGYGAGMGYGSGMGYGSGYMGGSYGSGYGGYGGYGGYGGGYGNYYGSNISPYSAKMTMIAMAGINFVGAISFFIASFSKSNIVRSRKFYLAVLISCIIMSILQAIINIVYIVGVNPMAQSSSNIMYNPMLMMCQNLYQTSYSQMGGMGGFPIYNQYLYHYCFVDPQEGVAMVCGFLVVLALGVAAFFAYKTRGKIWRYGKPNIYWEEPLVGGKASEGRDVEDWVNNVEESHSIQDAPTLLVSEKGGGPLNASANSVISYSPVKVDGTSYTGDDNQYSERTTSRPSEVFSYPEGISSSPSDETSGGRRPSAHRGKRRRRNPELDESQYETEYTTGGETGNELDMEEWESMYPEITTDSQRHDYKREFDADLREYKWLCADMDDINDQLNKLSRQLDTMDDTSSKYQAVADEYNHLKDLKQTPDYQSKKKECRRLRRKLFHIKRMVKQYDKNH
The following text describes a protein:
Function:
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR.
Subcellular Localization:
Cytoplasm.
Sequence:
MTCQSSQTIEGGPQEADGAAAADTDQNRIASAMKELRSTGWYWGNLTANEAKAILQDSPEGTFLLRDSSQRDYLFTISAMTSAGPTNLRIEYKHGKFKLDSVVLVKPKLRQFDSVVHLVDYYVQLSRSTDKAASNPQAVATGPNGTVQLLLTKPMYTAMPSLQHLCRIAINRRTQQTHHLPIPNRLKDFLTNYTYNV
The following text describes a protein:
Function:
ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
Subcellular Localization:
Nucleus. Note=Binds to myogenic gene promoters.
Domain:
The CHD1 helical C-terminal domain (CHCT) may bind DNA and nucleosomes.
Sequence:
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKKERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRPVPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSRLGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDVEYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNSKTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVVPLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESEPQEMDIDEILRLAETRENEVSTSATDELLSQFKVANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQTNDSDSDTESKRQAQRSSASESETEDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADLKRLGELIHNSCVSAMQEYEEQLKENASEGKGPGKRRGPTIKISGVQVNVKSIIQHEEEFEMLHKSIPVDPEEKKKYCLTCRVKAAHFDVEWGVEDDSRLLLGIYEHGYGNWELIKTDPELKLTDKILPVETDKKPQGKQLQTRADYLLKLLRKGLEKKGAVTGGEEAKLKKRKPRVKKENKVPRLKEEHGIELSSPRHSDNPSEEGEVKDDGLEKSPMKKKQKKKENKENKEKQMSSRKDKEGDKERKKSKDKKEKPKSGDAKSSSKSKRSQGPVHITAGSEPVPIGEDEDDDLDQETFSICKERMRPVKKALKQLDKPDKGLNVQEQLEHTRNCLLKIGDRIAECLKAYSDQEHIKLWRRNLWIFVSKFTEFDARKLHKLYKMAHKKRSQEEEEQKKKDDVTGGKKPFRPEASGSSRDSLISQSHTSHNLHPQKPHLPASHGPQMHGHPRDNYNHPNKRHFSNADRGDWQRERKFNYGGGNNNPPWGSDRHHQYEQHWYKDHHYGDRRHMDAHRSGSYRPNNMSRKRPYDQYSSDRDHRGHRDYYDRHHHDSKRRRSDEFRPQNYHQQDFRRMSDHRPAMGYHGQGPSDHYRSFHTDKLGEYKQPLPPLHPAVSDPRSPPSQKSPHDSKSPLDHRSPLERSLEQKNNPDYNWNVRKT
The following text describes a protein:
Function:
Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MAAVALPLLLLLASLVTPTPARDPFAPQLGDTQRCQQRCRQHHPGSPPAQPEPEGPSESPNNKAILISACERGCRLFSICRFVAKSSRPNATETECEAACTEAYVKAAEQRACSEGCWGQIPEPETQLEQKDLALDPPRGRLSLRYLFSMLCSDLMSSAQGFLSSSWTYSLQTDNRKVVVFQTQPVAENFAFQGSHLQRVEVTWRRSHPKALELHMDPVGPLDKVRKAKPRVKTSKAKVESEDQQESDFLSCMSRRSGLPRWVLFCCLFLSILIMLWLSCCTLVTTPGQHLKFQPLTAEQHKGLLVESDWPLYPPLPPPAYEDSTPPYKLKLDLTTL
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MSVVRCTVVYRSLNRGLSVNRFKNSQTRSKSENTSSDVNNLSIPEKSYANESITKKRARLHWQSRKRGISENCLIFSTFAAKYLNSFSPEQIEIYDKILNKPNNDWDVYYWMVGTKNVPNEYQSEIMDMLQEHCRNNKKEERFIQPALEYEPVPAKES
The following text describes a protein:
Function:
Metabolomic profiling of different yfcC over-expression and deletion strains suggests that it may affect the glyoxylate shunt.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSAITESKPTRRWAMPDTLVIIFFVAILTSLATWVVPVGMFDSQEVQYQVDGQTKTRKVVDPHSFRILTNEAGEPEYHRVQLFTTGDERPGLMNFPFEGLTSGSKYGTAVGIIMFMLVIGGAFGIVMRTGTIDNGILALIRHTRGNEILFIPALFILFSLGGAVFGMGEEAVAFAIIIAPLMVRLGYDSITTVLVTYIATQIGFASSWMNPFCVVVAQGIAGVPVLSGSGLRIVVWVIATLIGLIFTMVYASRVKKNPLLSRVHESDRFFREKQADVEQRPFTFGDWLVLIVLTAVMVWVIWGVIVNAWFIPEIASQFFTMGLVIGIIGVVFRLNGMTVNTMASSFTEGARMMIAPALLVGFAKGILLLVGNGEAGDASVLNTILNSIANAISGLDNAVAAWFMLLFQAVFNFFVTSGSGQAALTMPLLAPLGDLVGVNRQVTVLAFQFGDGFSHIIYPTSASLMATLGVCRVDFRNWLKVGATLLGLLFIMSSVVVIGAQLMGYH
The following text describes a protein:
Function:
Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Sequence:
MAAAAGVAAGTGRGSGEGEELLPNAVEGDGGCGGGGTCAGDRPWRLNFDGLRRPEAHQEKPPRRFHDRLGGLVQSPGDDVAEYYQQQSELLEGFNEMDTLTDRGFLPGMSKEECEKVARSEALAIRLSNIANMVLFAAKVYASIRSGSLAIIASTLDSLLDLLSGFILWFTAFSKKTSNPYRYPIGKRRMQPLGILVFASVMATLGLQIILESTRSLFYDGDTFRLTKEQEKWVVDIMLSVTSVKLLLVVYCRSFTNEILAIYTIRTWSMTVLENVHSLVGQSASPEYLQKLTYLCWNHHKAVRHIDTVRAYTFGSHYFVEVDIVLPCDMPLQEAHDIGEAPQEKLESLPEIERAFVHLDYEFTHQPEHARSHDTL
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSWYKQLGNSVKELRFVFCQSCGRSEGVRNLVTKNYWQWKETNPKFPFVVRECESIDPYILVRYKYGVEKKALIGNLNEAELEQVLGQLVAQSNKVNSTI
The following text describes a protein:
Function:
E3 UFM1-protein ligase that mediates ufmylation of target proteins.
Sequence:
MDAELLELQRQLEAAQSARSSVRLSERNVVELVQKLQERGIIDFELLHTTSGKEYITSDHLKHEIKMEIKKRGRASLVDLSDILGVDLYHVERQSQKVVADDPSLMLINGEIMSQSYWDTVTEEINEKLQERSQIALAEIAAQLHIGSELVVNILEPRLGTIVKGRLEGGQLYTPAYVSRITAMVRGAARGITVPTNLPSVWNSLQLQLQEMHGASGVSVEGSFFQSIFNGLLKEGVVLGSVRAGVQWTPAVFAHAQKESVDAFFSQNSYIGYEVLQKLAIPQPKQYLEARYPDGIALEAVFVHPSVVDMLDAAVGDTIENGQWIDALSVLPSYITGPDATKILSLCPSLQKAIKSSKAVVFGESCVFSNAFIKGIFDRLEKEMDSFGIKHSAGQGKPSNMSSEHRIGSDGKDLGDNDTSSIGASSDKGPKKKRGKVSGSAKGAAVEKDDDNEESIPVKGKKAHRKNKDAGSSGDAKHGGKKASEKTKEDNTNIFPDDLIEQKVLTVAPELEELGGSDDLNGPLKLLSSHLRPMLMDAWMKKRNTMLSENAERRRRLLDNLQKQLDEAVLDMQLYEKSLDVFEDDPATSAILHKHLLRTMGAPVVDKILLTLHKDNKLKNGMDVEDSEENVQLSTADRTSLAKDLPGSLSVKAQALAETLEGKRFDSFMDALRDTAEESGLLFKKLDKRLERSMLHSYRKDLTAQVSSENDPISFLPKVVALLFLQAYNKALQAPGRAVGAVIALLKDKIPAPTYKVLADYHSTTVKVLALQAAATEDGEDCATDRMLERKEDLEERLMPELKSLVLGTSKE
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSLGGQQLLEYLEKLPGTAFRRLYQSPATALAIFRRMLSYHAKVIVRGLLYMPDPFPLTSLDIWFPPEGGGKIHRDRTIAALRSLHILQVSPPSKDRTQEIQITASFKKGLQLAFEGGGEDGSFGVPSSLPVDPSIDIAYLDRYARKKWDDILHYVVNSLGVHGSSEGVSGPKASVKELLLAGRLVERRPDTRTGIGITQAGFTFLLQESNAQVWTLLLLWLEAADHTADSGMDSIDMLSFLFMLSSLELGTAYDTSALTETRRNMLPSLVDFGLIYFPRDTRQFFPTRLATTLTSTASALRTVSSAFTAATANPSGEPGTTTSTSGGPAATPDKTQTAAKGIIIETNYRIYAYTTSPLQIAVLALFCQLNMRFPNMVSGRLTRDSIRQAIGFGITADQIISYLHAHAHQQMVREATVTGKPVLPPTVVDQIRLWQLENERMQTTAGFLFKDFESTEEYAALSRYAEEIGVLVWKNDKRQLFFASKHEQLRDYLKSRKKGE
The following text describes a protein:
Function:
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
Sequence:
MAYVPAPGYQPTYNPTLPYNKPIPGGLSVGMSVYIQGITSEHMRRFCVNFVAGAHPGSDIAFHFNPRFDGWDKVVFNSHLGGKWGSEEKKRSMPFRKGTHFELVFMVLAEHYKVVVNGNPFYEFGHRLPLQLVTHLQVEGDVELQSINFIGGTQPLGQGPGHTQQQPSSLPTMEGPPVFNPPVPFRKRLQGGLTVRRTVIIKGFVPFTSKSFVINFMVESSGDLALHINPRLTEGLVVRNSCLNGSWGSEDRKLSYNPFIPGQFFDLSIRCGMDRFKVYANGQHLFDFSHRLLALQNVDMLEINGDVTLSYIQV
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MTENTTPYYKKQASYQDKRYTINKSNLIEPIIRHRIQDSLFYKQHLYLSNEATILPIIIEHVHYIGGTDSSNRPSTFISCLFRLLELEPSKEIIKTYLTQLDFNEFKYLTALTLIYIRLTYPSQEVYSIFDQYFQDFRKLRIKLKTPVFDSQKLPIHYKITFIDEWVDTLLVNERVIDLMLPRLIPRTTLVERGQLAPRQYYIDVSDEEEKDAGEEEKDAGEEEDNDYESDSD
The following text describes a protein:
Function:
May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.
Subcellular Localization:
Secreted.
Sequence:
MSCKFAALSTWSSGNQDSRGGCLRPQKQCGRVRKAAAGARPEVAMRIPRCAPLLLLLLLPPLLLTPPAGDAAVITGACDKDPQCGGGMCCAVSIWVKSIRICTPMGKVGDSCHPMTRKNHFENGRQERRRRKRRKRKKEVPFFGRRMHHTCPCMPGLACSRTSFNRFVCLARK
The following text describes a protein:
Function:
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.
Subcellular Localization:
Chromosome. Cytoplasm. Nucleus, nuclear pore complex. Nucleus, nucleoplasm.
Sequence:
MKTSLFGQPFGQQNPSSQGLFQPPAFGQQPVMNQSAGHGNPIFGQTPVFGQSQPSSTVSSAPAFGQQPLGTFGNTNASSFGQNSVSNQGSVLGPGSGFGQPPAFGVTSAFGSNPTLGQPQPLFFGQTSFGQTSSTSSSTSVFGQTPNITQSRGFGSSEFSFKPANDAIFKPIFSASPEPTNPQITPVSGSSFCAAGSQVSSSTNAGFSFLTGSKAGPAGFNLSQPAPVSSSSSQNNSLTTACGDQTKTLPFSFSHFSLKNFQTQPTPLSVGAGFDQLSAFGEPKSKVETSLDKNDSNLSGQGNSNIFREFSKGTKRKDPAMPVLGIQKPATDQDAPSRAESPRQPSKRPLIRSRGQPGGLLSRALNAIRKDQSSSVRNEGPKENPQQAGTWEETERKAAQPQEDDLPETKAEMSTPASRGERSESLDSLGGMSPSELTNIMCRNIPQELNKRNKIEKHFARFGKVCKVLCRPAKNLAIVYFNDHAAAAKAKKRGKQLSRLKSQVSFLKSLCTFNMKCIGGILKKNVEGIRLFSSGVSSSFSSPVRRASPAKVLQFDADSQKEIKTESLSSERPVPSSLLPLIGQVAETAEEKFRLLEQRDKILRQGRSKRTDLDLAFVGTCPDMCPEKERYMRETRNQLSVFEVIPNTEMVNHTAAIKEYSRSSADQEEPLPHELRPLPVLKMTMDYLVTQIMDLGQDNYRDWYDFVWNRTRSIRKDITQQRLCCPQTVSLIEKCTRFHVHCAHHLCEEHMSSFDPKINTENMTKCLQSLKEMYEDLAAHQTFCPSEAEFRQYSVLLKLNDGDILRSVQQFRDEVRNSPELKFAVQAFAAVNSNNFVRFFKLVKGASYLAGCLLHRYFNQVRAKALKVLNMALTVGPRSTPLPVEDVARMLMFPNSAEATDFVQQFGLNVTDGMVELSRVVYQEPEIPPSPKRSAVIIAKKTVLNGEVVNGGPLPIPPHHTPQCSFDLQNKYRGELPTSNFIKGINSFAGVLVLTFTINISVSISHLHRLGAAFTMLFLTFLKATLTFPALISQLFPFISQPEPVKPPSPPPEPQPMYSDEDIMAELDCVIEEVVKAEVKEVTDEGAAYIAAALQVFALVYIFVLSGRWRDVVAVRRQLKRQMRGFPAAPCCVDPCFKLKALAPSAPTQPSLADLARGMVNLGNAGSLTLSSTRLLEMRQEVTHQMRVHYYFQQLLEKHVWAPLDLVSLVTENIPIAHDRIFWKALLLLPSDQESAASMANRVLSDWLEAKLGGEQQSEEHLDGSLWTLCVTNALQESGRRTQKVHIAVKASRGPLTDNNLSRVERCSELQGTGALILLVPALPVFEPGLQDQGVPDSLLSALLQLKQLQQVNTWHCPLPLVILVPGPDGGASYTNNQALSWLLARATPPLSLSCQTLMQLIETSLGRELDPRVFAIRQERATAHLLPQEPAPIIRLYNAILDHVADTVASQHLCRLSWPPGEFSLPHTRSFVPHLAWNSVEHLAWLRKAILSLQLPEWEPLPPTDSWSELCSFIFHYAAKIPASHLSQPLLKSRLENLLERVRVKTHLTQTCGFRGNMEYNSRAQSQSISQIPWDDVVMICIDHKLKDWQRPEESVCEDALTAGGDILVYFSAESLKDFRAPEDWTEAVRKTHEEKKQEKNW
The following text describes a protein:
Function:
Probably involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATFVSELEAAKKNLSEALGDNVKYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPEGAGSLPWTGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRLRDGHFKYAFGSNVTPQPYLKNSVVAYNSLIESPPAFSAPCAGQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERVIMKLWHPNHEELQQDKVHRQRLAAKEGLLLC
The following text describes a protein:
Function:
Probable ATP-dependent zinc metallopeptidase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MALRLAQSKAAMHLARRGLAHVICNAPASFRANAATGAGSIVRRLHSGAASRLRDLNRMGLHSGAASCLTHLNRRGLHSGAASRLTDLNSSDLERVIYNFESQPSLYSKPSALSEYVKALVSLEMQTQGVEGSQLLSKDGALGTATAPLHMVTMEKGKIWKLLWPTFGTIVAAGLATGLATYGGKALGDKVSEKVTEAADQGLVVFAGKIPSELLGELEDEYSGVEEAGGKFSGQKTKAGNFGSLKEVTSTTTKFRDVKGADEAKADLEDIAHYLRDPKRFTRLGAKLPKGVLLVGPPGTGKTMLARALAGETGVPFFACSGSEFEDKYYGVASKRVRELFSEAKKRAPSIIFIDEIDAIAGPRNTEDPMWMRHTLNQLLSEMDGFKQNDGVIVIAATNFKESLDKALVRPGRFDRHVLVPLPDVEGRRQILESYISKVKAKGVDVLTIATGTPGLSGADLANLVNEAALTAAKDGAKAVTMHHLEYAKDRIMMGSERKSAVIPDHSRKMTAYHEGGHALVAIFTDGADAVDKATIVPRVGALGMVMQLPGEDAEFELSRKQMLATLDVMMGGLVAEELIAGEGGVTTGPSTDLSEATQLATDMVTKYGMGKRVGFVTYSNGGDASSGKATNMSERMSELVDEEVKDLLDNAYKNAKAILTDRRKELDALANALLKDETLTGDQIKKLVTGGGSKWF
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MSNTKYVNFARRNKCNVFKVNNNRISKHDAIGDANEKCFPHKTKLKRSIMHITVTEEEEEIQMLRRRYNDKFSVSKVIETFQDFPLSKKTLAGLAEADFTRPTVIQRESILPAIFGKDILAAAKTGSGKTLAFIIPILERLFVEKWTRMDGLGALIITPTRELAVQIYETMTQVGRHHDFTIGLLIGGQNLKYERNRLHNLNIIIGTPGRLLQHMDQNPLFDTTNLKILVLDEADRCLDMGFSATMDSIIENLPEVRQTVLFSATQTNSVRDLARVKLVNPVQIAPHEHEQIATPAKLQQSYVVVDLANKLTMLWSFLQTHPKQKVIVFFSTCKQVKYFYQVFKKLRPTSLLLPLYGGMNQEKRNKIYGDFCKKKTNVCLLATDVASRGLDFPKVNWVVQIDCPEDVAQYIHRAGRTARLNTSGENLLVLLPHEVDPMLDSLEKNKIPIKQIKIDERQLFSPLLKIQSLLAQSPELKESAKRAFVAYIKSIALMKNKEVFQLHNLNLDEFANSLGLSNTPRVRFVSRTLERKRSKILNTSDSESKIKITGIETKDSSDEEQDLDDFLRIKHIHNSSHCFASDDLQASNVTTESEDVKKIQKKRISKVKLVKKSLHMSKRIVFDEDGAPVNTNGEQSNKFYDFKDARFRLEQQDADDKKRYKALKKAKRMIIKEKERKRQVDDSCVLADDFGSESENSVSLDWLPDPDKVYGKRNHNGKQVDYKHASGSYDFKDTVKRIRVLQNAQALSLNDTEQLAINLLK
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
Miscellaneous:
MISCELLANEOUS: Target of the inhibitor of GPI biosynthesis YW3548/BE49385A.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MFGRLLLLGILFHVVFLKSIFDIYFVTPLIHGMKQYSAGEAPAKRLFLIVGDGLRPDKLLQPHSEKVIGEEQTYAAPFLRSIIQNNGTFGVSHTRVPTESRPGHVALIAGFYEDVSAVTKGWKKNPVNFDSVFNQSRHTYSFGSEDILPMFSEGASDPSRVDTFMYSSELEDFSSNGIVLDEWVFDRLDELLAQSLEDKELWDMLHRDKIVFFLHLLGIDTIGHNKHPDSVEYVENIQYIDGKIQELVDKMNNYYNNDGASSWVFTADHGMSDFGSHGDGNLDNTRTPIIAWGAGIQSPTHEKNYGHDEYSLPWNLTEIKRIDIQQADIAALMSYLVGLNFPVNSVGQIPLDYLDCSSRRKAEVALMNALEIGEQYNLKSASKDQTSIFFRPYSPLRNYTEVQASFYNSVIADIESGEYEIAIEHCFHFSQTVLSGLRYLQRYDWLLLRSIVFFGYLSWIGYVICFVFSLNIEPSSKIVKPVSVVKRVAFNIPFLLICIFFYIQSSPPFYYGYALFPTIFLQLIHSIFPNTKLGFKNFLTVAKQKHGFSLLKILFISLCILCLLQFIVYSYFHREGFSVILMGLAAWPWLLHADYAFSHKTISVSWSVLTSLLCFFTILPVNKKESLLFIFAGGFAMSVAGVFYILYRRNQAFQYSSTVTNKQLVLQVLIIMATVPVTLKIADSLQRNIAIPPILRLVAFGLFITSYIIPSHHIRSCKHYFLDRLAILFLTFSPTMCMLSISFEALFYVVLFITLGLWMELETELQKYTEQLHPEYSRKKDAKFHLSLSHIRISLFFYIFINVAFFGTGNVASLSTFALDSVKRFIPVFNPVTQGALLMYTILVPFIALSAAFGIMNKRLGGIQQVTFFLAVGMADIVTINFFYLVKDEGSWKDIGVSISHFCISNFLILFITALEHASAILCKNITYTIHEKVN
The following text describes a protein:
Function:
May be involved in DNA replication and thus regulate cell proliferation.
Sequence:
MMDGRRHSVDIPVSRALVAIMRSRSLRDPDTNSLAKFSAKKTIWEGCSIDEDEQQEGASNNKTTYGRHSFSYNAYDHLQRRREEFGDSLRSGRLADSPINIIKANAMAKAVLHNQSCCSAISGMSSRGAKDRSFGLVGDGEELGRRGEASTFQESSRSLLQKYRPKSFSELVGHGVIAQSLSGAVLKGKLAPIYLFHGPHGVGKTSMARTFAAALNCRSPGGNQPCGRCDECVAIFSGSSSSVVEIDASKLDCKSRVAALLRNACEVPASSHFKVMIVDDCQHMDKEGWYSIYNSLEGIPESTIFVMITSDIDKLPSNSIGWCQSYRFCKIDDAEIARRLIKICTKEGMEFEAEALDLLARKANGSIRDAIQMLDQLTLLGKRISKSVTHELIGDVSDEELLDLLNLAMSSDAATIVRRARELLSSKVDPLQLLAQLANLIMDILAGKHPSDSSEVRRVNGKHTSADVDVHKLRNALEILSETEKQLKTTKNQSTWLTAALLQFNMREPYCLDDTAVSSMFTESQTDDGTAVLKDESLDTSSHLCSQNKVSSLDMNLGDPDVLETIWMKALENCSSPPLQNLLRKDGKLSSLYTTQGVAVAELQFCHPEVVPTSESFWKPLCASLQNLLRCNVDIRINLSPISGSRAGSKDSSVSLVMESREDRQAQDPVTSNCRTVVSSRRDCPSPLVGQAKEKPPHILGCLHGGADGDTVDTEPRILSYQKISVVPAASTPGNAPLKATAGDTSKVDEGRVRRGCCSLLLPCSVCAPLRKSRTREKRRAKLFSCCFCKIGPDCKTKAEAG