lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Serves as a base for tail tube protein polymerization and acts as a template for tail length determination. Exolysin involved in host peptidoglycan digestion necessary for viral DNA entry into the host cell.
Subcellular Localization:
Virion.
Sequence:
MSQNLKIILTPQADTSSKTVEQLNQQIKSLEKKLNSLKLNTNIDSTTLKALQEFSSAIDTYQKNLKSYNQTVKETSTVIKNADGSVEKLTQQYKKNGEILQRETKIINNRNTALKQETQEVNKLTQATEKLGQVQKKTVQRNLQGQPTKVVQKNRHGFDDIVYTTDPKTNSTSSKTTTNYDQQRRAIEQLKQDLEKLRQQGIVTDTTISSLGRKINTAQSAQQIEALQNRIRMLDDKSAAVAKNNELKKTIELYQRQAQVNVQNLNTRYGSSMGSSNRQAVQDYLNAVNSLNVSTGSNNIRSQIQSLNMQFRELASNAQTAANQASSFGAELTQTFKSMSTYLISGSLFYGAISGLKEMVSQAIEIDTLMTNIRRVMNEPDYKYNELLQESIDLGDTLSNKITDILQMTGDFGRMGFDESELSTLTKTAQVLQNVSDLTPDDTVNTLTAAMLNFNIAANDSISIADKLNEVDNNYAVTTLDLANSIRKAGSTASTFGVELNDLIGYTTAIASTTRESGNIVGNSLKTIFARIGNNQSSIKALEQIGISVKTAGGEAKSASDLISEVAGKWDTLSDAQKQNTSIGVAGIYQLSRFNAMMNNFSIAQNAAKTAANSTGSAWSEQQKYADSLQARVNKLQNNFTEFAIAASDAFISDGLIEFTQAAGSLLNASTGVIKSVGFLPPLLAAVSTATLLLSKNTRTLASSLILGTRAMGQETLATAGLEAGMTRAAVASRVLKTALRGLLVSTLVGGAFAALGWALESLISSFAEAKKAKDDFEQSQQTNVEAITTNKDSTDKLIQQYKELQKVKESRSLTSDEEQEYLQVTQQLAQTFPALVKGYDSQGNAILKTNKELEKAIENTKEYLALKKQETRDSAKKTFEDASKEIKKSKDELKQYKQIADYNDKGRPKWDLIADDDDYKVAADKAKQSMLKAQSDIESGNAKVKDSVLSIANAYSSIDISNTLKTSISDVVNKLNLKDDLDPEELEKFSSSLGKLQEKMQKALDSGDEKAFDNAKKDLQSLLETYSKSDSSIDVFKMSFDKAQKNIKDGDKSLSSVKSEVGDLGETLAEAGNEAEDFGKKLKEALDANSVDDIKAAIKEMSDAMQFDSVQDVLNGDIFNNTKDQVAPLNDLLEKMAEGKSISANEANTLIQKDKELAQAISIENGVVKINRDEVIKQRKVKLDAYNDMVTYSNKLMKTEVNNAIKTLNADTLRIDSLKKLRKERKLDMSEAELSDLEVKSINNVADAKKELKKLEEKMLQPGGYSNSQIEAMQSVKSALESYISASEEATSTQEMNKQALVEAGTSLENWTDQQEKANEETKTSMYVVDKYKEALEKVNAEIDKYNKQVNDYPKYSQKYRDAIKKEIKALQQKKKLMQEQAKLLKDQIKSGNITQYGIVTSTTSSGGTPSSTGGSYSGKYSSYINSAASKYNVDPALIAAVIQQESGFNAKARSGVGAMGLMQLMPATAKSLGVNNAYDPYQNVMGGTKYLAQQLEKFGGNVEKALAAYNAGPGNVIKYGGIPPFKETQNYVKKIMANYSKSLSSATSSIASYYTNNSAFRVSSKYGQQESGLRSSPHKGTDFAAKAGTAIKSLQSGKVQIAGYSKTAGNWVVIKQDDGTVAKYMHMLNTPSVKAGQSVKAGQTIGKVGSTGNSTGNHLHLQIEQNGKTIDPEKYMQGIGTSISDASQAEAERQQGIAQAKSDLLSLQGDISSVNDQIQELQYELVQSKLDEFDKRIGDFDVRIAKDESMANRYTSDSKEFRKYTSDQKKAVAEQAKIQQQKVNWIQKEIKTNKALNSAQRAQLQEELKQAKLDLISVQDQVRELQKQLVQSKVDETLKSIEKSSSKTQGKIKDVDNKISMTEEDEDKVKYYSKQIKLIQQQQKEAKKYIKQLEEQKKAAKGFPDIQEQITEEMQNWKDKQKDFNLELYNTKKSIKDIYKSLADEVVSIYKEMYEKMRDIELEAHQKATQDLIDEIDKTDDEAKFQKELKERQDSIQKLTDQINQYSLDDSEFGKSKVKELTEQLQKEQLDLDDFLKDRESNKRKEALQDQLEKDEESINNKYDNLVNDERAFKKLEDKIMNGKITDIAKQLNEFSKFINTNMESIGKSISNNLIDKLKEASNALNTAVKGNTTGKKVSSFASGGYTGTGLGAGKLAFLHDKELILNKTDTANILDTVKAVRETAVDDSPKWGQGVKLADLIKKGITSIPSLVPNVNQSMLTNSLIPNLKKIEIPSKTIASSGDKTINLTNTFHIDKLIGGESGARSMFESIKNEVVKLNGSM
The following text describes a protein:
Function:
Hydrolyzes cytokinin glucosides thus liberating free cytokinins.
Sequence:
MAEDNLCALFFKLTVQGVTCSDGLKKHMENAEDELKPLLEHGPQGESMDIDEEEVSGAKRLLYLYVDCPTMMRCFFGRSMPYNCRGGTLLTDLPPYHADASPHEVSRGLGKATDFFSYEDAIRSAYFAAFSFSGPVRKLDQQLELTSTRGEPLTFSLYARSPGRLEPGELVRHGECKFAG
The following text describes a protein:
Function:
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin.
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLSKPIEGPVYGFIFLFKWSEERRSRRKVGPSMEESFVVDEDIVNDMFFAQQLIPNSCATHALLSVLLNCPQISLGSTLTRLKYFTRGMGPESKGWAIGNVPEIARAHNSHARPEPRHLPEKQTGISSVRTAEAFHFVSYVTTNDRLFELDGLKPYPIDHGPWGEKEDWTEKFRRVISERIGNATGGENGHDIRFNLMAVVADRRQQYETKLNTLKTNRQIVLEALQQVGGVNTKKSIQYAEVSHVCLHPPKFVPCSDDCAIWDALRYSSALRCSLIQHGCEHPSIPRSDGSTLVSWPSCVTSVNIVVSGHLKYVLLCFSIILDHKLEKLVPARLDPIKVNEPHLTSLIPSAFGRESHHKSKASSTVTSSSAAASSSAAGTDGVQPAEMKPDEFLHPDASRRVGFLEMPWRSDEARPLSIHTGYSKIPSPAPSNESTDTASEIGSAFNSPVRSANRSALQTIPEGSITKQEGDTKTDANIITVCLKRSLSGEGGGPPAKRLHIGDPDMALQRLGSGDSVEGDPMALQGGSGTGDAQQDQHALQAGGARPNMAHAFAPKDLLALLKNVETEIQICEQHLKDEIEKRKKYKVDDCRRTHNYDDFIRTFLRMLAEQGQLSKLVDQHVLVRRRQGVSVGRLHKQRKPDRRRKRARVSDKYRRKKQ
The following text describes a protein:
Function:
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody.
Sequence:
MATGDVRGNFERLKVQLRSISYPHALDIQGCNEGLPAAILPLIHYALLGYSRHVARYLSVNGYVLYAKSDLRFVECVMKLLRKEFEYRCPLTIAQIFGRGFAEKKFLFVHDLIQMCKRKHNDLLRVVRNSEKKTPVCRPKAFGTLLHQSQRRPILRNKHLSSKFDRRCELDLLPDIKCREVRQRSSCQDNTWFVPPEGRTRLSGVAEEDEDDIRAQSLQRAKQRGLRVLTRVKDHNIDATCHIPHMHIGTGSSAIMGAQMIHRDRGCGSMSSDPAFQGRDREHEETSPRSSSDFTRPKHGNTSMSFGDYPVPLEEPVTNKKFESQSQTPTTPENNCPLDHLHKNHLASSKACGRFDIPTLITADDPPQAMWQKIIDLASKIDSCFCSLDNKIAQSFNSLDEKLETKFKYLDEGVASTRETLQEKLIVLENRIENLERTSQISPMSLQSNVTYNDSHPIRDITNTFNSSIDNRSWRNYPGLPLRDPLIYYPNLFQQQDTQSIQNIPMHAGLLRTNTQDFIACVKARFHQTKEMLNVNDTLSF
The following text describes a protein:
Function:
May be a proton symporter involved in the uptake of osmolytes such as proline and glycine betaine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDTEAPAPPTRRPVRQLLAASVGNAVEWYDWYAYTFLATYIADQVFPKGADNSLVPLLSTFAVFAVGFFMRPVGGLLMGAIADRRGRRAALTVTILLMGGSSLLVGLTPTYAAAGVLAPVVLVLARLLQGLSVGGEFAASTTFLVESAGPGRRGLFSSFQYVSTTAGQLVASGIATLLVDTLSEDRMNGWGWRLPFVFGAVLSLVGFWIRQGAQETRSTEQQRAPRPALFEALRRHPRESLLICGITAGGTIAYYTWTSYLPTYAELNAGVAKSDALLAGTISLAFFGLLQPLGGLLSDRFGRRPLLLFFGVGFALLSVPLLHSLRDSFAVLLLVQCAGMVLLTGFTSISAAVNAEVFPPRVRAAGIGFPYSLTVALFGGTAPYVGTLFKDLGHSGIFPWYVAVLCLLSSLVYLRLPETAHKELRR
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. Can use a range of NTPs; has highest affinity for CTP (KD is measured as 17.2 uM or 0.160 uM in 2 different papers) while KD for ATP is 331 uM or 75 uM in the same papers. Gly-169 plays a role in NTP discrimination.
Subcellular Localization:
Cytoplasm.
Domain:
While ADP, ATP, ITP, TTP and UTP can be crystallized in the enzyme in approximately the same place as CTP, it is their phosphate tails that anchor them to the enzyme, their nucleoside moieties do not bind in the same way CTP does.
Sequence:
MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
The following text describes a protein:
Function:
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination. RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends. MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR. The MRN complex is also required for the processing of R-loops. The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation; MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA).
Subcellular Localization:
Nucleus. Chromosome. Chromosome, telomere. Note=Localizes to DNA double-strand breaks (DSBs).
Sequence:
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Plays a role in regulating the entry into the dauer state. In hermaphrodites, may play a role in modulating the rate of defecation.
Subcellular Localization:
Perikaryon. Cell projection, dendrite. Cell projection, cilium. Cell projection, axon.
Sequence:
METAERISAAASAASSRRAKRLAQQAHKTHPVIQAKQNQMYLITTLSPAQVDNSLINRVLPKEVLLKVFSFLDTKALCRSAQVCRSWSILALDGSNWQRVDLFTFQRDVKTAVVENLARRCGGFLKELSLKGCENVHDSALRTFTSRCPNLEHLSLYRCKRVTDASCENLGRYCHKLNYLNLENCSSITDRAMKYIGDGCPNLSYLNISWCDAIQDRGVQIILSNCKSLDTLILRGCEGLTENVFGSVEAHMGAIKKLNLLQCFQLTDITVQNIANGATALEYLCMSNCNQISDRSLVSLGQHSHNLKVLELSGCTLLGDNGFIPLARGCRQLERLDMEDCSLISDHTINSLANNCTALRELSLSHCELITDESIQNLASKHRETLNVLELDNCPQLTDSTLSHLRHCKALKRIDLYDCQNVSKEAIVRFQHHRPNIEIHAYFAPVTPPTDQVVNRGGICRCCVIL
The following text describes a protein:
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MTDFPVFPSNDPTEWKFLAEGSDSILFGYVGTSIDSLKGKAMRLFKKSLLPNKVYITPEERKHKLQLHVNYIKRFAGSVLQDIDLGDIYTVTSEFIQKLAEITQPLRSERRVKESVIDVATTICCLHTNHCPMGSLTIEIKPKWGQKPVFPLIPADSVKRTVSRFQLLQRLKLAKGEIKSISEYEPEDLFSNDRQRITRAMEAMIKNPQGNLKFFVDNQQVDVDEKKALKFVDVLLQIPHLNQLLKIQSLDVIDIEGIDMILDRAGQLSWENLVEDQYVIDGVKKMLNGEIKVPETAEEMKKYLENLDEKQCRLLVAAFLIATAAKDCSFMFTFDNPEELKNPAISVIDFDMKYPENLRKYYLDIDRKIVATYLKSIGK
The following text describes a protein:
Function:
Essential protein required during embryogenesis. Believed to act as a core component of the putative HOPS endosomal tethering complex and of the class C core vacuole/endosome tethering (CORVET) complex. CORVET is required for vacuolar transport of SYP22. HOPS is required for the central vacuole formation. Involved in root development. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (By similarity).
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Co-localizes with VPS39 at subdomains of the vacuolar membrane, and with VPS3 and RABF2B at punctate compartments in the cytoplasm, with faintly dispersed distribution in the cytosol. Sometimes observed at the vertex zone, the ring-shaped edge of vacuole-vacuole contact sites. Co-localizes with RABG3F.
Sequence:
MDQGRQVFSVDLLERYATKNRGMITCMAAGNDVIVLGTSKGWIIRYDFGVGSSNDIDLAVGRTGEQSIHKVFVDPGGSHCIATVTGVGGAETFYTHAKWLKPRVLSRLKGLLVNAVAWNRQQITEVSTKEIILGTQDGQLFEMAVDEKDKREKYIKFLFELEELPEAFKALQMETANISSGMRYYVMAVTPTRLYSFTGIGTLESVFASYKERAVHFMELPGEIPNSELHFFIKQRRAVHFAWLSGTGIYHGGLNFGAQHSYPNGDENFVENKALLDYSKLSDGTEAVKPGSMALSEYHFLLLIGNKVKVVNRISEQIIEELQFDITSDSVSRGIIGLCSDASANVFYAYDQNSIFQVSVIDEGRDMWKVYLDLKVYAAALANCRDPLQRDQVYLVQAESAFTDKEYLRAASFYAKINYVISFEEVTLKFISINEPEALRTFLLHKLDNLSKDDKCQITMISTWATELYLDKINRLLLEDDTAIENRDSEYHSVIQEFRAFMSDCKDELDEATTVKILESYGRVEELVYFANLKEQYEIVVLHYIQQGEAKKALEVLQKSSVSVELQYQFAPELIMLDAYETVESWMANKNLNPRRLITAMMRYSSGPHAKNETHEVIKYLEFCVHRLHNEDPGIHSLLLSLYAKQEDDGALLRFLQCKFGKGRENGPEFFYDPKYALRLCLKERRTRACVHIYSMMSMHEEAVALALQIDPELAMAEADKVEDDEDLRKKLWLMVAKHVVKQEKGAKRENIRKAIAFLKETDGLLKIEDILPFFPDFALIDDFKEAICSSLEDYNKQIEQLKEEMNDATRGADNIRNDISALTQRYAVIDRDEECGVCKRKILMMSGDFRMAQGYSSAGPLAPFYVFPCGHSFHAQCLITHVTSCAHEEQAEHILDLQKQLTLLGSETRRDINGNRSDEPITSTTTADKLRSELDDAIASECPFCGELMINEITLPFIKPEDSQYSTSWDLRSETNLANQRTISLPV
The following text describes a protein:
Function:
Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow. Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MDKDLFQNVLIKVLILVLMVLNAGFCYSVRTDDHVNFPEQISAWTGSCVLIPCYEKDNRRINNFLWYQNPEYDDDKKQWTRTVVYDNKNTKKVDSHFEGRVKPYVGQGNGACGIVLHNVQEGDSGYYRLRTIDGNDQWMTKKNVSLTVSDSGPELMIRPVGVGREYQKLTLSCYVHYYCPDYDIKLSWDGDVRGETKTTVPRLEWSVRNKKPIMTEAEFTFTPTWEDHNKTIQCALTKGDSEVTKTGPVVLNIQYSPKGVRIRPETSPVTISKGEEVALECTAESSNPPIDTYRWYKSANNIVGSNSHYSARESGTYYCEAENTIGRTRSKGVAINVLYAPTVTLKIPSREIREGSQYTLTCSVDANPQLVNITWYKDYEKILNKNRDTLTFPYIREQESGSYHCEAQNIIGSESSADVYVDVVYAPKNPEVVVEPKKPSFVEGSSLRFSCNVNSSNPGVSQITWYKNEKVMASERKNYIIIDTIKEEHHGNYMCKAGNKIGATSSQAVSINVLYPPKGVRVTPQAQIITEGDRIRLACSVDKSNPTVTEFRWYKDSALQPHRNKEITFPGIKRTDSGKYTCEARNGIGNVTSQPITLNVQYAPVGVMVSSIPSNLVTEHTKVTLTCTAQAYPNTISYAIYKDGVLLKYSQSLVLDYIQLSDGGEYYCMATNSIGSGTSRTIDIHVSYGLTSIGKYIGIAVGIFTLLVLLIVAIHFKIWKMVFRFKADDSESHFIVMKKTHPELPDNAARQSPPVGSHLDQLNYSIIQFPPQPEGGAASRTNPNDQGVIYSVLQKTSKAHEYENTTSGTQEENSDEIHYSTIANLPRGGMVPSRTSEVEYAMLSTQQNINSTQQNIYS
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MQRLMFLLMLTQSCADNPAFKALLSEKALTDLSQMMPVWIQSKMKSTAIPDIHDQVDIGIGWVNYVLSHMRVVQCETAEPSLVFVEGTGLYLEVRELSLAVSGRWRTKFGIITDSGSFDVEVYNIYIRVVLGVGDKDGHLSISSESCSNDVGNVYIQFHGGTSFFYQLFEDYFSGKASDMIRQKICPAIQQAVTNMETILQERTVNIPVDKYVYLSAPLTSAPAVTDQSCRLEVKAEFYSRRSPSEPPFSARAFDLQYSDKHMLTLAASQFTVNSAAFAYLRSGALQTNITDDMIPKGSPLHLNTSQFGVFIPQLRTLYPDMKMQVLLYASDMPLFSFTSGLMNIHVKMAAKFSAVKADDALVPLFTLNVDSRFSGIAQISNQKLTGAFKVNNITLTVGSSEIGDFKTDTIRQVLVIAVNTIILPKLNARLRSGFLLPTLQGFSLSNSQLLIKNGFVVIFTDIRLPDGLNAP
The following text describes a protein:
Function:
Catalyzes the final step in the metabolic pathway of hydroxyproline.
Sequence:
MAFVANSLRTLSKLGTLAVHQRTFPVGGVRVLDCVHRGMASFKKVDLSGVFPPLPTPFDQDEKVNHEHLRNNVTKWNEIDFRGYVVQGSNGEYTYLSDEERVELVRTVKQAAAPGKLIIAGSGCESTQATIAMTQKMAEAGADVAMVITPFYFKGRMTSQAFKNHYEKVASASPIPVILYSVPANTGVDLPADVVAALSQHPNIIGIKDSAGDVSSWNTLTVVKASVFCPVVEIELYLNTHTVVLVAGAVGCVAALANTLGNEVCQLHKLCKEGKMDDAMKLQHRLIAPNSAVTRKFGVPGLKVAMEWFGYYGGPTRSPLLPLTPEEEESMRADFQKNGFL
The following text describes a protein:
Function:
Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
Subcellular Localization:
Endosome.
Domain:
The OCIA domain is necessary and sufficient for endosomal localization.
Sequence:
MSSTSTGFPEERRRTAQLGVDYVPTEEEKGVLRECNQESFFYRSVPFSVISMAVTQALVSRGTLSPSPRFGSLPKVAFAGFCGYLAGKLSYMKTCQEKFKQLENSPLGEILRQKSGMTPPQSEMSNPDSQSFGTMFQAAEAPRFPSPSSKDYESGLDPPEQVGRMGDFSAPTQSYLDEEEPRRKPVLYEDLRLKNRENYEVTLIQKADTMIKTPQEKEPERPKKQGKQQRHGVTLHL
The following text describes a protein:
Function:
Bifunctional effector protein that is secreted and delivered by the type III secretion system into eukaryotic target cells. ADP-ribosylates several eukaryotic proteins including CT10 regulator of kinase (Crk) proteins. In turn, induces atypical anoikis apoptosis by transforming Crk adaptor protein into a cytotoxin. Affects host cell morphology by disrupting the actin cytoskeleton. In addition to this activity, acts via its N-terminal region as a GTPase-activating protein (GAP) for host Rho GTPases including RhoA, Rac1, Cdc42 and Ras. The bacterial Rho-GAP domain activity induces mitochondrial disruption in the target host cell by activating host caspases 3 and 9 that execute cellular death. This activity also causes stress fiber disassembly.
Subcellular Localization:
Secreted. Note=Secreted via type III secretion system (T3SS) and delivered into the host cytoplasm.
Sequence:
MHIQSSQQNPSFVAELSQAVAGRLGQVEARQVATPREAQQLAQRQEAPKGEGLLSRLGAALARPFVAIIEWLGKLLGSRAHAATQAPLSRQDAPPAASLSAAEIKQMMLQKALPLTLGGLGKASELATLTAERLAKDHTRLASGDGALRSLATALVGIRDGSRIEASRTQAARLLEQSVGGIALQQWGTAGGAASQHVLSASPEQLREIAVQLHAVMDKVALLRHAVESEVKGEPVDKALADGLVEHFGLEAEQYLGEHPDGPYSDAEVMALGLYTNGEYQHLNRSLRQGRELDAGQALIDRGMSAAFEKSGPAEQVVKTFRGTQGRDAFEAVKEGQVGHDAGYLSTSRDPGVARSFAGQGTITTLFGRSGIDVSEISIEGDEQEILYDKGTDMRVLLSAKDGQGVTRRVLEEATLGERSGHGEGLLDALDLATGTDRSGKPQEQDLRLRMRGLDLA
The following text describes a protein:
Function:
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Sequence:
MDQPLPTHEDWMQMAIALAEEAGNVGEIPVGAVVVNAMGEVLATGQNRKQRDQNPIAHAEMLAIQTACRRLGHWRLNECTLYVTLEPCPMCTGAIIQARLGLLVYGTPDPKTGTIDSVFDLAASAASNHHLQSLGGVCQEQCREQLQDWFAQHRARKKQQSLVS
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFATLLVILTIFAIIYTACSSDLNDGVANEYVLEELNDNFGFLAIVCCIGLGLSVIALFCFRYFVNIFIWTMLIVTVLLTCALAGFVWYISAQPVSHNQISFKIAAIILTAFSLITATCILVWNEQIKLLIKFYEEAIKIVFAMPQIFLVSLLTSISVLGLIVTAICGTPLCQSSVRGATLVDSNFLSAVAKSSAGTFVFSTMQLLVFNITAIIGFFMIHSVQSVLIGAVFALVCAHCIFVVFQIAVDTLFICYCEDYCLNNGINEPFYATAELRQKKTFHDKMYIKLQKMVPSDLFINLGLCQKRKLTDVPMLIIFAICVAILMIIAMIYTISSSDINRGTNGHVLRVLINNSGSLAIGCCIGLGLSLIALFCFRYCVNVFIWTVLIVTVVLMFTNVGFSGYFWYCSGELYLNYEITKLITFIISTFVFLISTILVLVLREQIKLIIEFYKEAMKILFAMPLIFLVPLLTFISISGIFALFCYITFPRIPMNDAGEFYHVIWTSCIFGVVRITVDTVFICYCEDYRLNNGTNEPFYATVELHQKLKKVQDFTKGIEEKACVL
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MVTLLWSGVYFFLVIEIIVLVILLFPLPSFIAKKVPFFLRHVLKNKTLFIVVLSILTLCFCESIRSQIKCSHELDELGVDNPLLNKVTISSNKFRSERNMYLSGFSLFFIFVIWRVGVLYEQIDQKAEKERSSKVESKETTPVEETERPKTD
The following text describes a protein:
Function:
Could impart immunity to carnobacteriocin-B2 to naturally sensitive host strains.
Sequence:
MDIKSQTLYLNLSEAYKDPEVKANEFLSKLVVQCAGKLTASNSENSYIEVISLLSRGISSYYLSHKRIIPSSMLTIYTQIQKDIKNGNIDTEKLRKYEIAKGLMSVPYIYF
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Sequence:
MKRQFAKIKIAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPALSGGGGSGSGSSEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRLKNILDKEIQEISTLKRNVSRTLQEYTSLKRSHEAAIRLEEPAAKVNHIKSQQEECELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEKPAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQENGETNGTREVSSTTKENNHNHDPPATAADQNQQQAQPQVTTPISPNSFQTPKRPTVPAPPPPTNWKSSD
The following text describes a protein:
Function:
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MIKADNALLLEEPLLRVPYEMLRKNLKTVHKHMTQESTMVEQTLSKLQQSTQHVAAEYGEKQQEEARESLDQLISRVRGLKRKIATLKDEQNETLTTTKARVEHLNVIFDNEKETDPEKQKETEKKWLRTRLERLLTDYFLRQGFSETAKSFAQNRGITSLVDVTILDQCISVETSLRQRHSTAECLAWCSENRSFLRKTRSSLEFEVRLQHYVELVKSGRVEDALKYCQRFLSKNADIHLREIQQAAGLLAFPPGTEGSPYKDLYACERWNQLSRKFVQTFADVHGLSDGSSLLYTLSTGLSVLKTHSCRNFGAPAELPITADKDEDMDPSLTSSARPYARRSENLPSVFGSGFSIRMYGSDEIRGLDTLPVIPPRALANLSSMRRDIAMQNNLDLEESIEDDNEESEERTSGDGERDSDGAVPVEELEELPDAPPELLSAEYLARRIEEATKENTDIIPKTTLDMFNHFYPGCCTSHQLSRADACPVCSVELNSLAENLPYAHHIRSHLDADPVVLPNSRIFGRAKLMEYSHKMMKAAPNTVVDPTSFECFKIDELITAYPS