lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
May be involved in the transport of sterols.
Sequence:
MHGDKEDCDSGYPQIERRKKLPDPVLREKGVSLWSLIKDNVGKDLTRVCLPVYFNEPISSLQKCFEDLEYSDLLDRAYKYGKEGNSLQRILNVAAFAVSGYSSSEGRHCKPFNPLLGETFEADYPEKGVRFFSEKVSHHPTLIAFHCEGKGWKFWGDSNLRSKFSGRSIQLDPVGVLTLEFDDGETFQWSKVTTNIYNLILGQVYCDHHGLMQIRGNSQYSCKLKFKEQSIIERNPHQVHGFVEDHSGKKVATLFGKWDDSMYYVNGEVKGSGKPKVCCPSEATLLWKRNEPAPNPTRYNLTSFAITLNEITPGLQEKLPPTDSRLRPDQRHLESGEFDRANSEKQRLERRQRMSRKLQESGWKPRWFRKDGNGSYHYVGGYWEAREQANWDGCPDIFGEFNEETVDSSG
The following text describes a protein:
Function:
ATP-dependent specificity component of the mitochondrial Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Subcellular Localization:
Mitochondrion.
Sequence:
MSGLLRWRRLVSAATRAASTLTAAECCPAAATAAGAVAPSPPPHRRLQERRKWESSSSGSGGSSSSTDEPEPRRIRAEAHCPRCSKHMDILFSHRGPPAAAAGAGYQALNLCPNCRSAYFFLPHVLTPLQGTFVEIGRVRADLLDHPAARARDPIFWEAIRASSSSRDDGEGGGVAVHVPPGPPFHPNLNVVRVAGSGGGGGGAGDEGAGKEGWGGSNLGRDLPTPKEICKGLDKYVIGQDRAKKVLSVAVYNHYKRIYHQTLQKGSGADLGGFNGEADDDDNVELEKSNVLLMGPTGSGKTLLAKTLARFVNVPFVIADATTLTQARYVGEDVESILYKLLTVADFNVQAAQQGMVYIDEVDKITKKAESLNISRDVSGEGVQQALLKMLEGTIVNVPEKGARKHPRGDNIQIDTKDILFICGGAFVDLEKTISERRQDSSIGFGAPVRANMRAGGISSAQVTSSLLESVESGDLIAYGLIPEFIGRFPILVSLAALNEDQLVQVLIEPKNALGKQFKKLFSMNNVKLHFTDGALRIIAKKAMSKNTGARGLRTILENILMDSMYEIPDAKSGEKRIDAVVVDEDAVGSVDQPGCGAKILYGDGALDQYLSQIKVSGDGVGSEMDGEAELSSSRAIGM
The following text describes a protein:
Function:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.
Subcellular Localization:
Nucleus.
Sequence:
MCLRVEEWYYCYSQSCPGCGSKGCNSRGWTAAINIRLELALPTTPHTISPSNFTRLVSPLHALGQDGCAGLPKPLLSNTIGLWTLISPVARPVNLETMGSKKLAIDSSIWLYQFQKAMRDREGKGIVNAHILGFLRRISKLLYYGIKPVFVFDGGVPTLKKQTINERKKRKRGVQENLAKTAEKLLAAQLRQAAVIEAQKRSQVKATGELITPDAVYFDHPIAQDFSEKNAARKKRQSDPMDPTTTTSTTTTTPIPSPTKKSRFVPKDQYQLPPIEKVPSVTENDSDHRLATEMELKQFIHEFTPEDLDINSPHFQSLSTELKYEIIGDLRIKSRQPNRTRVEAMRKTNDHEFSQTQILNLKKRNDLTQKLLTVTDMVAKANLTIPIKIAAQRNKEYVLVKASEGWILGIENDDQKDTGSATNPVKVDAESEDEDVEFEEVKMDTPKRDKQLSKDSDDELEFEEVPLPAAPSKPKPTREQQEADWREAIRFHYGTRDPDSAVEVEETSAPKSKDEVELFRQSDEEDEVMRDIISELVAHDTSNQSGPNRDLGEGSSKGTRTMTPQNKPTETPKQQFNTLASTTSPTKSQPHVASKEMINSILESVELEEDDNFLIPSTIPPLPETQTASQANPTQTVTSNPEESPILSTEKADRQNKQISQESDLRSNETVTMPDDDTPQVTIPSIANTSTLGEAASEAPKRDQDEPPSLDSSENRTKSCPSTVLERKDNLPPEELPKSTDTSSNDPSKPSNLSPSPSSLPEGQTLPSTSIGHVPISQSKLSTSEANSNLLPSPTISTSKETPSQDRAVHFASDTTELDKASPDKIEDDRLVPQGDKSPQQGEAKRSDLGNNNVRSESPEISIPWSRTPTPERSIEKEAEAIGSDEEEFNRVIEAEEKAIDANLAMESNEWESFLSGLEDQEKLEGIRQEADSEVQRLKEQKAKDRRDADDVNLQMSQDIQNLLKLFGIPFVVSPMEAEAQCAELLKLGLVDGIITDDSDVFLFGGHRVYKNLFNQNKFVECYLMNDLDQELGLDQQKLIQLAFLLGSDYTVGLNGVGPVTAMEILSEFDPAFSAGVATAHHNPNLSGLLNFKNWWEKVQVGKDTELESRTSFRKKFRKKKDKIWIDDHWPNPAVAEAYLHPTVDHSTEKFVWGLPDLDGIREFLYDHLSWSSIKTDEVIVPLIKRQTQRLNGTVQTQGVLDDFFDYSVESNKTNRLAPPRIDSGISSQRLQKIVQNWREKKKKQQANKNHGKEKTTEQQQEEDEGSLSEEVVVRPSGKRPKRAKPIKPTAAENPPRKVRKTQPKKKIAPVDKPSATSRPATRQPARSKQKEPSAQVVQTTTYRSSKRIKSNPSKKSTTKSDDQESGETDIELLPVLGSSSGLDDSQSDFDFSSSCSDGEDEE
The following text describes a protein:
Function:
SOSEKI proteins locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes.
Miscellaneous:
MISCELLANEOUS: 'Soseki' means cornerstone in Japanese.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localize to polar cell edges in roots.
Domain:
The DIX-like oligomerization domain is required for polymerization, edge localization and biological activity.
Sequence:
MVLVGQGMEPEEAFTKVQVVYYLSRGGQLQQPHLIDVPVSTHSNGLYLRDVKRRLTSIRGKGMGDSFSWSCKRNYKNNFIWQDLADDDKILPLSDGELVLKGSELYTGFQEKAEFMDGQFDPENASQLPNKIKKLASKKFDFEAVKRSLDMESDKLQEQSDLAAALSLSLQLMSDPHMKRFSKDKSMDLNQQVMNSLSQAKSNAAEECMLDHSVTDISSETLHSEESTVQKFSFNETIRERSKSTASASSSGTDREHSYGPPRKTESMGRERSLPRDLPRSREVSRELPPQVPREAPREKSREMSRELPREAPRELQLPREAPRELPREVPRETSRELPREAPREISRELPREGPREVAREQPREVVVPREVVREVSRELPRDVSRDSSKAVKDTAKTRQEKPEELPTIKTKKSPTCSESGDSTPFMLSPRRLMAALSSPSPEKKFGKLVHSSSTRSSTPSTSAASTQCEDSLPNINIRLAKQATCLSNFRLCGNANPHATDSRPDSPEHPLAAAAQPASGAVPQSPNTRGHQGGPYWPRWRSGRKPRTSSEGKEGPEPPTPPRGPMTKPVTVAKPDPPLKKSFEFDMNVSGVNSAMATPFLQTENNSPSSSESSSAAVSSGKKPASISLSGTSDASDGGNGASSTASSSSEVQNNVSVKEVITQQLPSPSSSEGRPSLNIDTASLPRVSISEAISDVRETVKTTRPDSPESPMKPNPPSSPVRTQLSSSPSFNKRIEDARARARSLVSKEIRSGESRSSKDLLKENDRVKTSSGSMRSGSTRTPNNKNGTTGAGSKTLSGTFNRSPPRINSIMWEDAPLTPTKKEFVNRDDRPLTAGRTNLDWEKTLQEAASLSLPPPDFGQILQECGQCGRTFKPDSLKVHMRGCHALRRSKDFQPFNGTSVAIRTRLQ
The following text describes a protein:
Function:
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity).
Sequence:
MQQALEQALDRAEYIVESAQQRPPKRKCLSSGRKSIFQKLYDLYVEECEKEPEVKKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLVCDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSVAVACTANRLLYNRQKMNTRPMKRCLKRYSRSSLNRQQDLSHCPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNLAVPSEVDVEKYAKVEKSIKSDDSQPTMWPAHDVKDDYVFECEGGNQYQKTKLTILQSLGDPLYYGKIQPWKADEESDSQMSPSHSSADDHSNWFIIGSKTDAERVVNQYQELVQNEAKCPVKMSHSSSGSASLNSGEEGEPETSSIQSSVLGKGVKHRPPPIKLPSSSGNSSSGNYFTAQQASSFLKSPTPPPPSSKPSLSRKSSVDLSQVSMLSPAALSPASSSQRHES
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Also has a role in nuclear tRNA export. It acts between the steps of tRNA maturation/aminoacylation and its subsequent translocation out of the nucleus. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
Miscellaneous:
MISCELLANEOUS: Present with 16800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Note=Associated with ribosomal chromatin, even in the absence of transcription.
Sequence:
MPSLSQPFRLATLPKIASLSNFSLQADYVQVADGTFNESTNNITLGISGSSISQYIINPTPKLTFDYPIPSTNIITACNAEKGQANIDGNIEASTDDEANNEKTINTQKKRNVEIWAFGLMVNKGNYTLNVITKALEDTTDTSNDHLSESDIDNKAYTGSDEFLSQYKIKAKAKVMSIKIDTKNSLVIAILQNGLIEIFDFKLTLLHSFDISYDNLKYAKWFTENGTEYVFVLCPLQDDKVCYKLLELTDCGSGESSPIKELSSTIIEGFSFENSKLCYQFGKLYKLNQGKIYIYSLPHCQLQQVIEFPMVDKLSPGDDLISFQPVSVNRVLLTVNNVIYLLDLLHCSTLSQRELTHVKTFQLLKSAVINSEKSHNSKTIAIGISTKNGPNPTSSLEIINIDVGTNTLKDSLGKSFQVGNNDSSVILKPLFDDKDINDKRVKCNDVSGDSSVPVLHCNEVIEKLSALQDNDITSFDDIFFKELKIKEEHYTEKDRYISDPGFLNKVLDLIFGKFSGNDYPKTLTFLLTHPLFPLSRTRNLLSLLRDQPRLFKQAIVTCPNLPLNELLEELFSIRNRELLLDISFRILQDFTRDSIKQEMKKLSKLDVQNFIEFITSGGEDSSPECFNPSQSTQLFQLLSLVLDSIGLFSLEGALLENLTLYIDKQVEIAERNTELWNLIDTKGFQHGFASSTFDNGTSQKRALPTYTMEYLDI
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MEGQRCKMSDNIFEELGNGYRYTDRDFILTECTAAEKDDRLHVSIMEEHGFGIAYIKEEEEEKGILEEADPSDFNVGRLPVLEGSSAISYDSSQVLPSVENSSQSERELDESINDPTNSPPTHDEDSTGKQGFDCTKCKKRFSVESDLGSHVMMCCGNLSTQCPVCKKIFASKSYIEKHMRLHTGEKPFQCGECGMRFTRKHHLVHHQRTHTGEKPFKCTECGKGFIKKSDLKVHFRRHGGNEPFQCSYCDRKLNSKRDLIRHERTHTGEKPYPCSSCSKRFPRKQELLVHERIHSGENPFQCSYCNRKLNSKSDFMRHERTHTGEKPYPCSSCSKRFPRKHQLLRHERKVHLKAKSPETSKDSNDNSAVSFQKDLDKRKTCSDKSSYQCPECNKKFKTKLSFTQHMKEHTGDKIYQCGECKKGFTSESGLKRHMRIHTDIFCSSKNASDDLAYQEKISESQLSEDGCSEDDSEGASEGEHLEKEDHEDSESGWLPASEGISAVSQDSSQVLPRLENSSQSERELDESMNDPTNSPPTREEDSTGKQGFDCTKCKKRFPVESDLGSHVMTCCGDLSTQCPVCKKIFRSKSNLGKHMRLHTGEKPFECGECGMRFTRKHHLVHHQRTHTGEKPFKCTECGKGFIKKSDLKVHFRRHGGNEPFQCSYCNRKLNSKRDLIRHERTHTGEKPYPCSSCSKRFPRKQELLVHERIHSGENPFQCSECGKGFPRKQELLRHERKVHLKAKSPETSKDFNNDSAVSFQKDLDKQKTCSDKSSYQCPECNKKFETKMSFTQHMKEHTGDKIYQCCERKKGFTSESGLKGHMRIHTDEPVNSREEQLKVQIESGFEIYLIKEEEIEETSLQQNDVCCSSKNASDDLDCQEKISEAQLSEDGCLEVDSEGASEGVHLEKEDHEDSESGWLPVLEGISPVSQDSSQVLPSMENSSQSERELDESMNDPTNSPPTCDEDYTGKQGFDCTKCKKRFSVESDLGSHVMTCCGNLFTQCPVCKKIFTSKSNLGKHMRLHTGEKPFECGECGMRFTLKQHLVYHQRTHTGEKPFKCTECGKGFVEKSVLKVHFRRHGGNEPFQCSYCNRKLNSKRDLMRHERTHTGEKPFKCSECGKGFSQKSNLTLHFRKHGGNEAFQCSYCSRKLNSKSDFMRHERTHTGEKPHPCSSCSKRFSRKHQLLVHERTHTGEKLFLCSECGKRFSRKQELLRHESKVHLKAKSPETSKDFNNDSAVSFQKDLDKRKACSDKSSYQCRECNKKFKTKMSFTKHMKEHTGDKIYQCGECKKGFTSESGLKGHMRIHTDEPVNSREEQPKVQIESGFEIYLIKEEEIEETSLQQNDVCCSSKNASDDLDCQEKISEAQLSEDGCLEVDSEGASEGEHLEKEDHEDSESGWLPVLEGISPVSQDSSQVLPSMENSSQSERELDESMNDPTNSPPTRDEDSTGKQGFDCTKCKKRFSVESDLGSHVMTCCGNLSTQCPVCKKIFTSKPNLGKHMRLHTGEKPFECGECGMRFTQKPHLVYHHRTHTGEKPFKCTECGKGFITKSVLKDHFRRHGGNEPFQCSYCDRKLNSKNHLMGHERTHTGERPHPCSSCSKRFSRKYQLMVHERIHSGEKPFQCTECGKGFITKTVLKDHFRRHGGNEPFQCSYCNRKLNSKTHLMRHMRTHTGEKPFKCSECGKGFSQRSHLTMHLRKHGGNEPFQCSYCNRKLNFKSEFINHERTHTGEKPYPCSSCSKRYSRKDHLLIHERKVHLKAKSPETSKDSNDNSAVSFQKDLDKQKTCSDKSSYQCPECNEKFKTKMSFTKHMKEHTGDKIYQCGECKKGFTSESGLKRHMRIHTGERPFQCSQCYKQFVSKKQFKLHTLRHKRATLSCSYCDVKFLARGDLNRHIRTHTGEKPFQCDICKKRFNRNSDVNKHLQKAKASGQGPYPCADCDEIFCLKVGLTNHMITHIQPMPYQCSECLQKFKSSSELESHDMNKHKGKRIQFLSNL
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNLQIKNWPNKEKDWGIFAAGYRLVPFGSEISNKNRIRTGGFSAIQGLHHNLDKIQSPTARLPSPYNECGRSSNQKYSKHKRSSALNETTERNTNKQGRYGLRKIKSSQNRKSLNSGLKSLSRKMTPHSRKQNIVAKISSPVKPFICPKCKRRFCSNRNLLTHQRIHTGRRFVCSKCGKCFSHKMILIAHRWLHTGRKPFTCTECNKGFLWNKDLQKHKKLHEKGKMDISDLGAHSEGNPYIYTENRTSCRNNNMSETEFKTHTKDKSFTCTECEESFSLKSRLIAHLLIHTGEKPFVCNKCGKGFRRNQYLKEHLSTHREDRPHVCTECGKTYKYKCGLNTHLHSHKVNKRFPCSECGKILSSKTSLTIHLRYHTGKTFPCTECDKTFREKKTLKMHQMIHTGEKPFECTECGKRFREKRKMKLHCLIHSGVKPFECLECGQQFRLKHGLKFHQLSHTGERPYECSECGRGFRSSSELADHIRSHTGEKPFICNECGKSYRNHSGLIYHLRTHTGEKPFICNECGKSYMDHSSLVCHLHTHTGEKPFVCVECGKRFQKVSLLRIHLETHIRVKGFECVECGKSYVSEKGFKTHLLTHTT
The following text describes a protein:
Function:
Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development. Not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes. Binds RNA in a sequence-independent manner.
Subcellular Localization:
Nucleus. Note=Forms subnuclear bodies. Sop-2 is required for nuclear localization.
Sequence:
MTINIKYSSKFSSSKTSSSEELKPKTYIPAYYQPPVSMPKYYVNWLRIKLSLNKLKNIRAIYLFDQCQNFNQYQESSRKFSAGQVSSLTPWYSNFSNYSTVILRMKDTSLPPLENPSNGGTYLFNLITVFPSIALSFNYSWRGDTGPSISIFSFSLSVLFFSLFPQHKNICARAWCRPFRRSLSFSLRFIMSSEPASSSTEKVPEEPHPHSIKHKFQGPQFVIPRALSDYVLNVNNQTPESYEKALNAKYGRDDYITLCLHVTSLCTEYGPLDDGPEYVLLCDSRARVDKLIEDLVKLLEIDTDYVQLELHGGKRLHLQKPDAVLRDIAYKQSNEGSDKFFLEMKLVPSESMKAKIMKQEEEEEKARKHGQYQQYQEYHQQHQAMNDGQSSSSVPSTSSPSCSSEANRKEMETVREPAGPSELMRAINAPVAPAPVVIKIETPVALPEEDETLMDDDEMPSLTVEAPSEEASFEAEQPSPQVPQASIEGPSQQQQIPGTSQQKRQVARGSRTNMISYHDLPPGTGNAPPMACPQVTLKLEKNVPFEAKIRAVAGYTRKPISEVQKMRPSDLESIFHSICIASVQRIKRRNELVQQLQEINAQSCKSPTMTMNKKFTLAKAYQRVQNEIEKIDREQILPQQYMNMPPMPPQGQQRLPPPAYPPGILPPQQNRQQGVPPQFQRSPQFMIGPDGQRYAHPYMQLPNSNQRARILNTSSVQPSEEVRNRLVKIEAMAMNMAQLNPPRPPPPQPPHRALQGELQFLRPGAPDPCNFRPDSKQTYNNTYVTVASPATLTNSIIPWHFPPYEKSGRLNVSNTIKAINEYRLLCNSRQADPASFLEFYFLGDPMPHFNKILSIADYNMYLSRRRCDEADVKIHRMSHSDQLQLYLLELQSDESNVEKWKTFYRIMQWDLPLNNEFPRILLPSSLDIGRPVVDRKKKSIDQVMNHIHRMHSQRPPSMGNSSTSSEASSTSPTNAATATSSPASNRPTTSTAQPPTLNPT
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MVFILGVNFNEHKLVQKALESFYGLGQQASARILAKYSIHPRAKMGTLPPKIVTALTAELSTMTIENDARRLVLDNIKRLRDMGTYRGRRHAMGLPVRGQQTRNQIANARKLNKIERHG
The following text describes a protein:
Function:
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
Subcellular Localization:
Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.
Sequence:
MAECGRGAAGGALPTSPSPALGAKGALKAGAGEGGGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARTSPGRGPLGVALARTPSPAAGPVPRDSKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGLGHITLCHAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENVEQPNHVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDMMMQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENSEAQKPRRSLEAIPEKASDENGD
The following text describes a protein:
Function:
Segment polarity protein which functions in hedgehog (Hh) signaling. Regulates the trafficking and the release of cholesterol-modified hedgehog protein from cells of the posterior compartment (P cells) and is hence required for the effective production of the Hh signal.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLCFDSERMNWYYHVLARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETDHHGALFSNPSDLWERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVAQKMMQFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEEHQQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFVVQRIGPNATDSLFDLNGLLAMCQLQDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLLLGCYEYFHDLKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMIFIPVAQSNRLLPLFHEWEDVELINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPLWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVELANSETHELESLNSNSLIKTISGIESAHALSSLPRDFEHSFQTMHECKYQTYPSTSN
The following text describes a protein:
Function:
Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
Sequence:
MVKLSAEDLNDYLNPGVACVKPVKVQKKQDNQQNIKVNGESYYEVTKDTGEVEELGIASISLNDCLACSGCITSAESVLINLQSYHEVLKFVNAKEADDFFILQMSPQARASLAAYYNLSVQEVQLWIQSVFTNELKFNVVVDTGFSREISLRQAAIEFCQSWVAANAAKTVYNSKSGEVAPKPLPVLSSSCPGWICYVEKTHSSLIPHISTVRSPQQVAGRLLKDWFSYQLGISRKKIWVLSLMPCFDKKLEASRNDFVNEQVRDVDCVITPKELVELLKTKNISPQSMDLDSLSISEQTPCLPSWYEPVQFEQQNGSSSGGYLHYIMTFAAKALFDINDLTNRINVSQKNADMIEYELTSPDTGETLLRMATCYGFRNIQNLVRNVGRKSAPRRGRVLLKRMKNMSTSPSTGTGKQKLDYVEVMACPGGCINGGGQLPPPESSADFSGISREWMRQVEAHYFQPGVRQVDNAAVDAAVEHWLPSYSLQQSILHTKYHAVQNDTENPVALANTW
The following text describes a protein:
Function:
Probable transcription factor. Modulates lifespan and also recovery from the developmentally arrested larval state known as dauer, perhaps acting upstream of phosphatase PTEN/daf-18. Regulates expression of genes involved in cell division, cell-cycle regulation, and sexual reproduction, including daf-18.
Subcellular Localization:
Nucleus.
Sequence:
MPKVIQSSMSDYRSVPYNQTPKSASERKRRNITNELINECKTIVQKSEEEHISQEVVLFRIVKLVTGVNLESNFSSNDLSESTRRKFDTESERRKVKTEREKIRRKKQDDCYAELKFFILNKQMGSYEQRLKLERITILEIIIDYIKHNSDLLYPETIPQILPLLAGKSTATCENKENEKPKTRMEVKDLFPRLTFQEVQESPTSTSPLLTFPCIPMIPTTQFNVLSNYNTVPSIFSAPLRFILPSLQILTPETSDEEENEETLDIIN
The following text describes a protein:
Function:
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MAESSAATQSPSVSSSSSGAEPSTLGGGGGSPGACPALGAKSCGSSCAVGLSSLCSDEPPSKIMTSSFLSSSEIYNPDPTTPLGSETLGSHLVAKDGKDPLVLLDKKTLDSPQGTNKDRVDTPVSLAADIPCSHPSIPDSFPEQPTFLSKETDPTEEWVVKNQEPKNPSEVPSGEDRSALDLGQRKAEHICTHSLSPSEPAVASVEKDSPESPFEVIIDKATFDREFKDLYKESTDDLGGWAAHGDRESPADLLEMNDKVFPLRNKEAGRYPSSALLGRQFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQAKQQADKSPCTTESTGLDRSEHRSEIPVINLKTSPQQKMPVCSFNGSTPITRSTGDWTETFTEGKPVKGYLSSTKEAGGKGVPDSSQPISGSGAATVEVTLPDLRGTWPNSVLGEVTEVDSSGESDDTVIEDTTENPSVKNNKVLPEKSDSLPSAAVKTSERENKETTSHETVRSEMYENSEQQQAHAETPTQRSLEGQMSPQVPNMLNEVIPENLAMTDTTRVCSAAPPSVLSETGFSLTVPASAKSESLLGKNVEDTDGSSPEDLMAALTGTEEKGTVDKEKGDVLEAVLEKIANVKNTLPVELLHENKLSSSETKNTKSKYSEHSRETNGGAPKVSSDLEQEQLTIRAIKELGAKQVQAERMSPGGKLKRTFDPQSGPQNSSDILEHTDITTGSDLGIPKKPTIIKDTRIDSISSLTKTETVNKHVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHSYMNAAMVHVNKALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE
The following text describes a protein:
Function:
Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis.
Subcellular Localization:
Cell junction, adherens junction. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lateral cell membrane.
Sequence:
MDKYQEQPHLLDPHLEWMMNLLLEIVRDRASPPVLVHLAFKFLYIITKVRGYKIFLRLFPHEVTDVQPVLDMLASQNPRDYKTWETRYMLLLWLSVTCLIPFDFSRLDGNLSSEEGQTRMSIMDRILHVAETYLVVSDKARDAAAVLVSKFITRPDVKQKKMADFLDWTLSTLSKTSFQTMEGTIIMDGMLQALVSTFLNFKNHVLHLTTTSVVLTCLDNCRLSESNHTLLRKLGVKLVQRLGLTFLKPKVAMWRYQRGCRSLAANLQLSSKGNKPPSMGNVAANSEEDYDVPEEVENVIEQLLVGLKDKDTIVRWSAAKGIGRLTGRLPKELADDVVGSVLDCFSFQETDNAWHGGCLALAELGRRGLLLPSRLSDVVPVILKALTYDEKRGACSVGSNVRDAACYVCWAFARAYEPEELRPFVHQIASALVIAAVFDRDINCRRAASVIIFLLSPHLQGTFPHGIDILTEADYFAVGNKANCFLSISVYIAGFPEYTQPMIDHLISMKINHWDGVIRELATKALHNLTKQAPEYMIHSVFPRLLPSAVGPDLHTRHGAILACAEITYALYKLAAENKRYQGEITRRTGSFRMQAVLGTPLFNLNSCRAPTGSWQCLINDSLKSLHLISSSARQQIKVQAKPMFTSFWGDRFVPDELVQHFLSELQSAEEMTRCGFSLALGALPGPLFRGRLQQVIEGLKKVTHISPKNVSFAEARRDALKAIAKVCRSVGVKADGSPAEVVCAENVALIYSTLLGCMNDYTTDSRGDVGAWVREAAMTSLTDLTLLLGKAQPELIEADVCQRLLCCVAQQASEKIDRFRAHAGSVFLTLLHFDNPPIPHVPHREELERIFPRSEAATLSWKAPSQAYPYITQLLDLPTYRYHVLLGLVVSVGGLTESTVRYSTQSLFEYMKKIQNDLPALDNFCGTLLQVFEANLLNPRVSVPLLKMLDQMLANGCFDILTAEENHPFPLKLLSLCKEEIKKSKDIQKLRSSIAVFCGMIQFQGELRKKVFFQLFLLLCHPFPIIRMATASQVYETVLTYSDVVDAAVADEVMAVLSDTACASALLVMPHPSLRPPATRAGICESCVYPLHCILYSPTCSAYSKHSIIPIDGLVGDGRALY
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MAELETAAEHERILREIESTETACIGPTLRSVYDGEEHGHFMDKLELRIKNHDREIEKMCNFHYQGFVDSITELLKVRGEAEKLKNQSTDTNRRLQLEGAELISSMKELQQCRIQQRNIATTVDKLNMCLPVLEMYSKLHAQMKSKRHYPALKTLEQLEHSFLPQVSHYRFCQVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSERIGETAMKQAQQQRTLDNILSVQGKRGLAKRPRKCPSPELNGTSPMSEQDSGILDVEDEEEEEEAPGTQDLVDFSPVYRCLHIYTVLGSRETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFHQIIGFFVVEDHILHTTLGLVNRAYIDELWDLALSKTMAALRTHSSYCSDPNLVLDLKNLIVHFADTLQGYGFPVNQLFDMLLEIRDQYSEILLKKWALLFRNILDTDNYSPIPVTDEETYRKLVGQFPFQDSEVEKQQFPKKFPFSEFVPKVYCQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNCLQNVIKRKNVGLTELVQIIINTTHLEVSCKYLEEFITNITGVLPDTVHTSKLYGLTTFKDARQAAEEEIYTNLNQKIDQFLQLADYDWLVSDPSTQASDYLVDLVAFLNSTFAVFTHLPATSDTHSRMPGKVAQTACMSACKHLSTSLTQLLLEAEVKQITMGALQQFNQDVKECERFARSGPVPGFQGDTLQLAFIDLRQLLDLFIKWDWSTYLADYGQPTCKYLRVNPTTALILLEKIYRVMKDPSRKNNVFAQFRKNERDKQKLIETVAKQLRSLINSHHS
The following text describes a protein:
Function:
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity).
Sequence:
MTSLTFYIIIAFLSLATPSIDGNQLSLSSSDLVVDGYKNFINVIRQRLTENTLKLYDIPILESSLPPTQRFMNINIGNQNDETISLAIDRVNLGVVGYRSNNNSYIFLDAPKAALDVVFPETCRVVLGFNSDYESIEKASGTTRLQTLLGLEPLNSAISNLFHYRRADIPGSFLVILQMVLEGSKFKFIEQSVIQSLKYGYNFKPGLAIVSLEDNWDKLSSQIQASPSLQGLFGEAIRLYDSNDKFIDVDSIYYVIITTNIAFQLHHCNVSTNFIRMPSDVDDSCNVQTRTAMISGQNGFCVDSSRILDYNGNPIILYRCINQLNQEWTFLSDKTIRYSNKCLTFETSRYVVLYNCSEVEEKGNIRWNVAIDGTISNPSSGLVLTTDPSTNRSQLIVEVNKFTTSQGWRVGNYVKPIIGSIIGMEEMCLEATNNNTNMWLEKCVKNKAEQYWAVYSDGSIRVNRKRNLCVSSSSNRSGALLIIDECKGTSNQRWNFLANGTILNPETKKVVDVYGSMVSAKRIILYPKTGLANQQWTLFY
The following text describes a protein:
Function:
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Sequence:
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
The following text describes a protein:
Function:
Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
Sequence:
MSFATISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDTINRGEIHIVEPDLASVVKTAVEGGFLRASTTPVEADAWLIAVPTPFKGDHEPDMTYVESAARSIAPVLKKGALVILESTSPVGSTEKMAEWLAEMRPDLTFPQQVGEQADVNIAYCPERVLPGQVMVELIKNDRVIGGMTPVCSARASELYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINVWELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDHKPFWVIDQVKAAVADCLAATDKRASELKIACFGLAFKPNIDDLRESPAMEIAELIAQWHSGETLVVEPNIHQLPKKLTGLCTLAQLDEALATADVLVMLVDHSQFKVINGDNVHQQYVVDAKGVWR
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly.
Subcellular Localization:
Nucleus.
Sequence:
MGEDKDDRKVDRERDRDRSRDKEKDKERDKDRERDRDRDRRRSRSRDRKRRSKSKEKEKEKKRSKSRERERKRSRSPVKKQRRRKPSIYWDIPPIGFEHITPMQYKAMQAAGQIPANIMTEVAPQVQVPVVGNTITRQARRLYVGNIPFGVSDVRAAEEEMMDFFNQQMHLSGLSQAPGHPILACQINLDKNFAFLEFRSIDETSQAMAFDGINFKGQTLKIRRPHDYHPTPGGGGGGGGGGGGPETTPGMSSGGITEKRAGGGGGGGGGTMSTIVPDTPHKLFIGGLPNYLNEEQELLMSFGQLRAFNLVKDTATGLSKGYAFCEYADVTVTDQAISGLNGMQLGDKKIIIQRASVGAKNAAAYAQMPVQIQVPGFNLAAGPGQPTEVLCLLNMVTPEELRDDEEYEEIVDDIREECNRHGAVRSVEIPRPLEGVDDVPGVGKVFVEFISVSDCVKAQQALTGRKFANRIVVTSFYEPERYHRRDF