lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays an olfactory role that is not restricted to pheromone sensitivity.
Subcellular Localization:
Cell membrane.
Sequence:
MGLHKNYFKVGQNASNQLFGLPPSPGGPTPLSMLISQGAKFNSNRVAVIIFGIVTLIAGVILSSVPWLNIFIMKNLRLWNGTISFHYWQRPGVTRLTKVYIFNVTNPEGFLAGEKPKLVEVGPFVYREDMEKVNIKFHDNYTVTYQHKKILQFVPELSVDKNLRITTPNIPLLTISTQSKYLSFFVAKTISVILTATKYKPFISLTADELVFGYDDTLVSLAHRFYPRNRRPMEKMGLLNGRNGTLTEYATMHTGHTGMDKFGYFDKLNGLDHLPHWDGEPCRSIQASEGSFFPPRDITQKDTVYIYDKDLCRTLPLVYREPVEKDGISADLYTLAEDAYGPPNENNSCFDHSHYKKYYGLQNISPCQYGAPVYISNPHFYQSDPQLLDAVEGLEPNAEQHKTYFKIQPKLGVPLEGQVRVQLNLLVEKAPNVMATKDFRDFVFPIMWLEEGVSELTPPIRRWIYLATVFAPTALPILSYGMILTGAFAMIYVFVRAYKNFVFTDDPTTELLEMGRRSLRRGSHLISNGQHRILHRDSYILLKANGVVAAAGGESDIAGTGTEVVTSGNGSSNNNNHLLHNHNLLHSHHHHLYIQPKDQSLLAEEDSPA
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MTSESDEKIMAAADDANDGGNNPLKKGPWTSAEDAILVEYVSKYGEGNWNAVQKNSGLARCGKSCRLRWANHLRPNLKKGAFSPEEEHLIVELHSKMGNKWARMAAELPGRTDNEIKNYWNTRIKRKHLEFKNPEMNHHHHLYPPPPLLDHNVPAKRLCGAGSFFPDYLSADIGSHFQTDNCLQIAQSFIQSCSSCSSSSSSSEPSDWPMMKMELPSLQTHVGGAMWGPPPSPTLPPLESVDTQTLLCDILPENRNSGLLDAVLYESRIMKNSKNQDFHETAYCDYSSPSLFSEGSTPTSGTSFDEPEYLENITGCEVKGGFETTKQMNFNRPDFLLDSDYIDPRQDFIEDVLLTEDAVGNFLWS
The following text describes a protein:
Function:
Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEEPKKIDIKGKGRAIEDLIPDIDDEEDDVDFQDLSSSGESDDSDDSMQEDYDDIHDEEPEDYSAIDPTNIMCSTRTRRKKIDFTKVLEEGQNEDDFEEEDEDYIPPQDKTM
The following text describes a protein:
Function:
Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MRAGFSDFQLIRDQVLFLQDQAQRLTEWLQLSGFENPVSESTTLCLREREKRIPTCVAVCVPSPGTVHTALLHPTTLSQSRSSSEAKMLIIHTA
The following text describes a protein:
Function:
Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
Sequence:
MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPPGIPAQTLTTVKHTVKIEKDAVLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQINDKFAEDLSYERAADILREAGDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLVSGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIIVTVKEKLSIRSTEYFALALEEQYNISRLHLLHEEELIQQVVEREETHDYRCLFRMCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGKIFNATLMLQDRESYIALLVGAKYGISQIINSKLNIMSTLAEFANISRVELTEESEKVSMVKVYLQDVKVLTLLLESNSAKDLACLIAGYYRLFVDPVTSIFLWPGNKHQGHRVSAEEGYESRACSDSEESSEVDCMPEPRSDGRLPKPGPCRPLVQEQQPPGDSPAPEVARRGPSTCGASSTTDSAESEASDSANTESRGCRTSGSSESVDALEEDDLDACSSSRSGFFPFSSPGFLESLDSDSQEERNRIETSGFLCLLDLAQRANAQGQKTEFPESPAPETFSWGPELSAVPLDPRLYEGSQTAYYSLCSSVSPASHLSDSSENTASRQGGGPPAWGQQGWTEPQPSSTLEALAPHLPLAFEDGSSDEEYYDAADKLTPPDALSGPRAVSAADPSATSLQNTARTCSLEDSLNPGLDGRQPSRRGGVKKYAKTLRKRRSFLQTDYTCQVSFPLVPSASLESVDHVCYYDREPYLALGAPSLTVSSLQDVQAEPGLLETKALGLLASLGETKNKNPASRVMEMEPETMETKSVIDSRVSSISAVRLRIDPNHRENSAAVAGSPASTPRCSNPGLSGPDTAQAGPSQTLPPFQDSEGSAREELAIELGDSTSSLCSADLNPDRVCLTVSPGPHSVSPGDTLELGGVQLEMGLGSLFTNHMQEPAPKSTEPLLSPQDRPRSGECGTNSGEMMASFPTKEEQRGQLSLEDDGEVRNENGTNLFHDESGKDSGDAEGDAFNAIPQTVGVSDPASGAIASFSMETPVTGTEQTPAHSPMDRQAQSREPLGQACQTQEQRLLLAELDLDPDFLLRNQIIPLACPLEGVKAEPLNHVTGEDAAHRDTSQQVSFNPGPLLPKPPPCPQEEPHLESSNHGSLSESKDKSPSICFPAENAFLCLAPESHPKISANLRTATSLGFAGVNETAAPRFGMEQCSCQFSYATCFRGLQPETQEDDRDLEAHLTAPLTSPPSAGSRLAQPWRRTRAHSCSAEPLSRNNHTWPEYCSKALRQLKAAPTSTPEGFIQLTESLLELQDILDAAWGNANKHPPEKCTWHFSESRSRLCMGSQKLLSSCQHVIRMDQSAEEMQGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVDTYHQFVEAAKLTCERGYQDLSVKLLARQCTALTAAVFCLTQKFRASTAL
The following text describes a protein:
Function:
Acts on leucine, isoleucine and valine.
Sequence:
MKLPLSKYVWFDGKYVLTEKAQVPITTHAIHYGTSIFEGIRAYWNGKNLHVFRLDEHVKRFRRSGQFYNISLNFSDKEITEAIIGICKKNKIKKSCYIRPFYFVGDYGINLHVTEKAPTNVAMFTFPFGDLFNKNGISAGIVSWRKFSDMSTPPQAKMGGNYLNSIIATQEAKRNGVDEAILLDHNGNVSEAPGENIFIVREGQMATPSLASAALEGITRDAVIKIARDLDIEIVERDITRSELAMSDEVFLTGTAAEITPIISLDGKKVSNGKPGDITKKMMEEYTDIVMNKNDDYSHWLTAVY
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
MQSVTSPLSRRHMFDDSPSYKRKLVSPACMAGDLTAAAVHIETPTLPTPRRSLFTAKTPAFLNLPPPNDSSTPCGVPMKKSMSMMEPMSPLSAGSDGSTTFGSSTSSNTSSNTSTSSIQMHRLRKNNRSTSSLRLTSAGVSFDPIDEEGSLRKPFRFSLELDSPANTRFTHSMNEADSSMDTDEDGLGSLSQNFRLGGSTSHSNTHSLNFNGFTLGGAADESAGAVAAADVTADDINDTPSARPVRPSLNPLCKRSYNSSSTPFAAKFKRPRRTHSMFQDPKELMQEELDEEKEMVRRLSLSPDVNNNVDSFLVSADCTLESFSVEGDPFRRIKRETLVQILDGHYSHYYDRHVVIDCRFEYEYDGGHIDGAININSKDRLEELLSNEEGILGNNCNNMMRPGKRGGDSRKRTLLIFHCEYSAHRGPRMAMHLRNRDRRLNMTNYPHLNFPDVVILQGGYNHFFEQFHTRCYPPQYVEMNDSMHKSTCEREMGRFRRHMKLRSESSINKQQGVICSPVGLSRSLSENVDYHRPKRVVSCQLWR
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Mitochondrion. Plastid, chloroplast.
Sequence:
MATLVGSQWIRIRAFPEVSPPYFRHSSLSTLRRSPLRRISSISGSSIPSSGVDTPKRAEGEVRVRFAPSPTGNLHVGGARTALFNYLFTRSKGGKFVLRIEDTDLERSTKESEEAMLQDLSWLGLQWNEGPDIGGEYGPYRQSERNALYKQYAEKLLKSGHVYRCFCSNEELEKMKEIAKLKQLPPVYTGRWAKATDEEVEEELAIGTPYTYRFRVPKEGTLKINDLIRGEVSWGLDTLGDFVIMRSNGQPVYNFCVTVDDATMAISHVIRAEEHLPNTLRQALIYKALGFPMPHFAHVSLILAPDRSKLSKRHGATSVGQFREMGYLPQAMVNYLALLGWGDGTENEFFTLEQLVEKFSISRVNKSGAVFDSAKLRWMNGQHLRSLPSEDLTKLLGERWKSAGILTESEGLFINDAVELLKDGIDLITDSDKALSNLLSYPLHATLASEEGKSVLEDKLSEVAASLLAAYDNGEFLCAIEEGHAGWQKWVKSFGKSLKRKGKFLFMPLRVLLTGKLHGPDIGASVLLLHKAGKCNLISSQAGFLTLDERFKMLKEVDWEKFNKDQCHLSTVLASQ
The following text describes a protein:
Function:
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular Localization:
Cytoplasm.
Sequence:
MKIGVYGASGRIGKLLLEELKGGYKGLALSSVFVRQKCETDFSSFSHAPLVTNDLKAFVRACECVIDFSLPKGVDNLLEALLECPKILVSGTTGLEKETLEKMQQLALKAPLLHAHNMSIGIMMLNQLAFLTSLKLKDADIEIIETHHNLKKDIPSGTALSLYETCAKARGYDEKNALITHREGLRSKESIGIAALRGGDVAGKHTIGFYLEGEYIELSHTATNRSIFAKGALEVALWLKDKAAKKYEINEMFG
The following text describes a protein:
Function:
Inhibits the enzyme activity of ATPase.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSNKVIATAAFSLARRSAVYSVIPSASYSGNIREAGGGFSRRESAEEERYAHEQELISIRKLKADLAKREASIHTKLGLPVVEEPHQEVSPETFGSAGQHSSYAGGGSIGKRGAAAEERYIREHNAERVRILQEKNKK
The following text describes a protein:
Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Imported to nucleus via interaction with KAP122.
Sequence:
MSNAEASRVYEIIVESVVNEVREDFENAGIDEQTLQDLKNIWQKKLTETKVTTFSWDNQFNEGNINGVQNDLNFNLATPGVNSSEFNIKEENTGNEGLILPNINSNNNIPHSGETNINTNTVEATNNSGATLNTNTSGNTNADVTSQPKIEVKPEIELTINNANITTVENIDDESEKKDDEEKEEDVEKTRKEKEQIEQVKLQAKKEKRSALLDTDEVGSELDDSDDDYLISEGEEDGPDENLMLCLYDKVTRTKARWKCSLKDGVVTINRNDYTFQKAQVEAEWV
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSNFKNIIPKRTYLERGQAKHRLHLGELEKKVDYGKRREIYKKKKKIENVLKEKIMTKNPDEFHTGMVHSRVTEDNVLVREEKVLKKEVQLKNKRQELKEQTNDLYNKLKKINKRLSNYQMNIPLRYVFNNSHELYNENEIYTLKAENKKLKKRGDLIQKKYNGLINMKKNLLDQIRKLDNKYITTYHKVDGYNIVTDKGKTPYRLYQPRLK
The following text describes a protein:
Function:
Atypical and probable non DNA-binding bHLH transcription factor that acts as a negative regulator of cell elongation and plant development. Binds the transcription factor ILI1 and forms a heterodimer of antagonistic bHLH transcription factors that function downstream of BZR1 to mediate brassinosteroid regulation of cell elongation and lamina inclination.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing IBH1 show erect leaves with reduced angles of inclination.
Sequence:
MDAKRTPPPPTPPNPNPSVIGSGAAADGGGFGRGEAAAATKHMLAFHFLRALSRIHRATPVTRRTRTIRRAAYSSMARAASPRRAWSRALLGQVRARRSRTLMRRAAVLVRRRVVAAPAPSPASARGVRIIAAGETSAAARAVPPPPRQQGEPPRAEALRRLVPGGAGMEYSSLLEETADYLRSLRAQVQLMQGLVDLFSYQ
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Can also mediate cobalt and nickel uptake. Plays a key role in the adaptation to the low magnesium conditions predominant in the gastric environment. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Domain:
The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg(2+) binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway. Co(2+) binding also induces a conformation change. Low Mg(2+) concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex.
Sequence:
MVNVFFKQQKFVIKKRFNDFNGFDIEENEVLWFELINPTPNELATLSQEYAIHYNTDHSQRVSSVTKYWEDSSSVTINAFFTNQDENETFHTEMATFILSNNILFTIYYGTLEIFDSIQKKVLASPKKFEDGFDILTKIFEVYFEKGVECLEWINKQTSLLRKNIIFKETSTHDDILVRLSNLQEFNVTLRDSFFDKRRIITALLRSNKVDSDTKNNLNIILTDFSSLVESTTVNLNSLDNIQNLFASQVNVEQNKIIKLFTVATMAMMPPTLIGTIYGMNFKFMPELEWQYGYLFALIVMAISTILPVIYFKKKGWL
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MLLGNSSNMGHGHEHGHGKVELPDYKMWKIEGTRLEEVQERLARRGLKDPWLRNEAWRYMGGFAKPVSFMDVMSKGFKWGFAAFVVSIAIEYAFFPPKKDGGHH
The following text describes a protein:
Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Sequence:
MPDVEPAAPDFAASGRVGRRNALPDILGPSATAGAPDLPAKLAGLAGAEGNVGHRRGVLLPGVGAACQEFDSRLCHLSAA
The following text describes a protein:
Function:
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MKTDDKDREGGDSHGAIGAKLMEYALKVRKVFVTGGVDEKMAKDVVQQLHILASISDDPIYMFVNSPGGHVESGDMIFDAIRFITPKVIMIGSGSVASAGALIYAAADKENRYSLPNTRFLLHQPSGGIQGPASNIEIYRREIVRMKERLDRIFAEATGQTPEKISADTERDFWLNAEEAVQYGLVNKIIVSEREITLPGQ
The following text describes a protein:
Function:
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.
Sequence:
MHDAMAVLPKLQTGLDVNVKFTVVRDFEYTPECIIFDLLRIPLFHGWLVDPQTPEIVAAVVLEALVIENFLERSASQLTYHGLSELTTSMEDDQIGVLFRNNHFSTIYKRQKELLQLVTDQGFLGESSVVWETLGSIDGDGQFVDSHFRTDPPKPELASSGDSASPHPTSPHSASPHPLN
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MKTRGKTLTERYEMGKLLGKGVFGKVHYARDLESNQGVAIKIMDKDRVLKAGLSEQVKREITTMRLVEHKNIVRLHEVMATRNKIYIIMEYAKGGEVLDKVKRSSRLTEADAHRYFQQLIGALDHCHSRGMYHRDLKPENLLLDENGDLKEIKESTWFRKGPREISAVNEKVLSKNATTTNVVPVLPSRRKEIAHEDMKSLVATNLNAFEIIALSAGLDLSGLFIKECRKETRFTSDKTTLAIISKLEDVAKTLNLRIRKKENNTISIQGRKEGAMVSFSLTRRSLRSHHPVILFR
The following text describes a protein:
Function:
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Sequence:
MNKQRSQTPPIQNLPTTLTGMLMKFPRCAASLARSGMLSVQPAMPNVVTAAQSVGSQLLLSTMRRRNGIRPKSHVLFRRENAFSTRIQAVVTETSSGESATEVKAVITIRRNMKESFLEKLQENWESFSNSIGKGVLLQLVSEDIDPDTGKGKVSAVAAVRGYSSDNSPDRPDYLQEFAADFKLPPGFGIPGAILVTNPQKTELYLLGIIVNGLQSGILNFPCNSYVHTRIHNPDPRIVFVNKPYLPANTPGGIKDLRESDKASLQGKGEGQRVEADRIYDYDVYNDLGNPDAGVNRPTLGGELHPYPRRCRTGRPPLNSDPTVESRVESPETIYVPRDEAFEEVKDATFSGGNLKAVLHNIIPTLTSVLKSGDGPFESFDDIDDLYKEGVNCGNKLGEEKGSWRLLISNILGTFLDVDEYFKFNLPQMIFQDKFSWLRDAEYGRQTLAGINPSSIERLISFPIISKLDPAVYGPAESAITKEVLEKSMEGMTVEDGIVQKRLYTLDFHDMLLPYIDRINSLEDRNAYASRTIFFLDSKNMLRPIAIELSLPSKTAAMRGRSQVFTPGNSGTEHWIWKWAKAHACANDSGIHQLVNHFLRTHACMEPYIISAHRQLSCMHPVFKLLHPHMKYTMEINALARQDLISGDGVIESCFTPAKYSMELSSAAYGANWRFDKEGLPADLLNRGMAVEDDSMPCGIKLVIEDYPYAADGLLIWSAIKEWVGDFVGHFYRDDQTVVEDVEIQAWWDELKNKGHGDKKNEPWWPSMKTRGDLESALTTMIWTASGQHAAVNFGQYPLGGYMPNRPTVMKELIPEIDEPEYEKFLKCPQDAYLASLPSVLETTKVMAVQDSLSTHAPDEDYLGKVDESHSSWIDDDKILNLHEKFAGKLVEIEEIIKARNNDKRLTHRNGAGILPYELLMPSSGPGVTGRGIPNSISI
The following text describes a protein:
Function:
Component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. AIR2 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1.
Miscellaneous:
MISCELLANEOUS: Present with 1800 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MEKNTAPFVVDTAPTTPPDKLVAPSIEEVNSNPNELRALRGQGRYFGVSDDDKDAIKEAAPKCNNCSQRGHLKKDCPHIICSYCGATDDHYSRHCPKAIQCSKCDEVGHYRSQCPHKWKKVQCTLCKSKKHSKERCPSIWRAYILVDDNEKAKPKVLPFHTIYCYNCGGKGHFGDDCKEKRSSRVPNEDGSAFTGSNLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVSSISENMYGSRYNPSTYVDNNSISNSSNYRNYNSYQPYRSGTLGKRR
The following text describes a protein:
Function:
Catalyzes the formation of N-succinyl-2-amino-6-oxo-L-pimelate from succinyl-CoA and tetrahydrodipicolinate, a key step in lysine biosynthesis via diaminopimelate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MQQLQNIIETAFERRAEITPANADTVTREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIEGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
The following text describes a protein:
Function:
Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
Miscellaneous:
MISCELLANEOUS: Present with 22400 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The first transmembrane domain is not required for stability, membrane association, interaction with LCB2, or enzymatic activity. The second and third transmembrane domains are required for stability and interaction with LCB2.
Sequence:
MAHIPEVLPKSIPIPAFIVTTSSYLWYYFNLVLTQIPGGQFIVSYIKKSHHDDPYRTTVEIGLILYGIIYYLSKPQQKKSLQAQKPNLSPQEIDALIEDWEPEPLVDPSATDEQSWRVAKTPVTMEMPIQNHITITRNNLQEKYTNVFNLASNNFLQLSATEPVKEVVKTTIKNYGVGACGPAGFYGNQDVHYTLEYDLAQFFGTQGSVLYGQDFCAAPSVLPAFTKRGDVIVADDQVSLPVQNALQLSRSTVYYFNHNDMNSLECLLNELTEQEKLEKLPAIPRKFIVTEGIFHNSGDLAPLPELTKLKNKYKFRLFVDETFSIGVLGATGRGLSEHFNMDRATAIDITVGSMATALGSTGGFVLGDSVMCLHQRIGSNAYCFSACLPAYTVTSVSKVLKLMDSNNDAVQTLQKLSKSLHDSFASDDSLRSYVIVTSSPVSAVLHLQLTPAYRSRKFGYTCEQLFETMSALQKKSQTNKFIEPYEEEEKFLQSIVDHALINYNVLITRNTIVLKQETLPIVPSLKICCNAAMSPEELKNACESVKQSILACCQESNK
The following text describes a protein:
Function:
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Sequence:
MPNYLLRLAFVGTNFYGWQVQPNLRTVQGEIQKALSQILCEDVKVTGCCRTDSGVHALDYIANFKTQKDFPEEKLLKALNGILPKDVGVYAVKKVSEEFNARYSVKGKVYLYKIWNSEVRNPFLYPFSWQVKREINTEVLRNILKKFEGTHDFRALTKLEEERNTVINLEEVSLNVEYPLIEIRLKASHFLRYMVRRIVGTAVKISLGLYSEEVLEELLQGKGNSPYTAPPQGLHLEKVLL
The following text describes a protein:
Function:
Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis. Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis. Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSGVNVADLLATTMTLPITAAAGAATSQAAATSATNASHLQPATLTGHISTTAAAKTTTTPTSSLPITSQFVDASLTSLSLTATSSDASYSSPFSSYLSSDSTFELLSTVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQLSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTGGTIISGPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGFNILSLLSKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQHSDTDSTPNKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGESPQQPATPPPSLSPPELPEPSGLLIASSSELAEIFRSLSFPLGRPAGAPQRLSTLSDQVCANYLMSPPNTPAPPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVTSLPMPVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVSGNGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVSTSSAKHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTANATATANADSTIDTTVTTSSKRSIHEQTPDLGQRPASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATGGSVRPAKGWKAEHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVVLFWIGYFNSTLNPLIYAYFNRDFREAFRNTLECVLPCLEKRNPYNAYYV
The following text describes a protein:
Function:
Component of a polyphosphate synthase complex that utilizes ATP to synthesize and translocate polyphosphate to acidocalcisomes in epimastigotes, insect-stages of Trypanosoma brucei. Catalytic subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as a vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation. The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen. PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase. The VTC complex also plays a role in vacuolar membrane fusion (By similarity). Essential for infection and parasite survival in the mammalian host.
Subcellular Localization:
Acidocalcisome membrane; Multi-pass membrane protein. Note=Localizes to acidocalcisomes of procyclic (PCF) and bloodstream (BSF) forms of T.brucei.
Domain:
The SPX domain has very high affinity for inositol polyphosphates. SPX domains may integrate inositol pyrophosphates (PP-InsP)-dependent signaling to adapt cytosolic phosphate concentrations to different metabolic situations.
Sequence:
MPFSKAWRSAVYPDFREQGAYINYKATKDTLHRMKEDIANPATPDELYNSLLMQKATVYKWCENKVKELQMMAEALMKASDYLSEEETPTNMSMVFSMVGSSEAKYLPPSDARRVADAITYELLRFVECRNLNTDTIEHIIARMYRYAVLGPTGDRWKNINKEYDYHALSIDEIFFMLSKVYEHVNEVESMRRDGRSSIPCGTVGSQVFDRRSVKYWVHMQDLPFVIARIIPHLPLSTFQDTYAMSKERGVPFTLGSPISSVYYDNDKFLLYHRRLERLDGATLIRMRWYGRPLDSDWNKLESKDSVFMEIKVHHEAWSGERSNKRRFALKEKDVDAYIRGDLSLKPALEKLRSKNASEAEQEKFMSLATEILTKIHAYDLKPVLRTQCQRAAFQCGLDQSIRISIDTDLRVVAEDFGLSHHWRYNGADAPLSHFPYAVVEVKLQCAENERIAPWIEELMNCRYMESVPKFSKYAHGIATLYGHTPFIKMVPYWMPQLDIDIRASTKPEYNQWDPTIGIASGCWERTTDRVIFGTGHAQTQTVGASEARFLPRTDCLRTYQRVLKAIKRGAHMNSVAPTMSPTDRPPSDEKKLTEQQELAPVVQYDTDRRHKAYTAFHLYPYCEDGVESLCFTSTGGKHVAAEVFSGLIPWQTGKRIRVPQKYDPKTLLTSERFMVKWAEQATRVGVVGLAVIRFGNSMSLPNDMVAVHSFWRANFHIVLGSLMVVVAECVLVYAYVTFKSRSRRVYARRKIRYDDRRGPVALTFVILAVILITVMMHVMVRYGPMLTGSDTF
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane.
Sequence:
MAVEVRDLTFRYANKEEPALRKVSMRIEEGETVLLAGRSGSGKSTLIKAINGLIPNRYEGHYEGEVEVLGTLVRGASLSHLSRLVGTVMQEVGKQLVLPNVEDDVAFGPCNLCFPRDQAIARVESSLRSVNALHLRGRDVNELSGGEKQRIAIAGILALDPPVILMDEPLANLDSEGVRLVQEQIRMMKDRGKTLVIAEHRTEEILDVGVDRIIFMENGKILREMREERELKDLFGVIKVPSRVLIEECGELRVRSERRELGQISIKMEGVSFDYDGKEALKDVNLEIREGERIALLGNNGAGKSTLAKLILGILKPRRGRILVYGMDTREREVYELANYVGLVFQDPFSMLFARSVEEELSYGPRNLGVGSDEVRERVMEASAKCGLEHLLKYSPFATSHGEKKRISVASILTMRPKILILDEPTAGQDYASYTQFMDFIMGLFGSVKTLIIITHDTDLAVEYTDRTIILSNGRIIADGPTRSVLANEDYLRAGKIRETSLIEMGKRITGGKMVLSLREILESCS
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSSQLASQLQKLQHRPVDDKRLSGSFLFSDGDSRNFSREQIHQLAVHGLQTLIAVDNRFHFFVNRLFDPHGTRAERKQLRRDANQELNEAVEQFLTLLSPHIFLTAAHQVFEYLVRVHEVHVYNVSAVLRAFLPYHDHSLFSRVLLLLDLRDTGLEFLAANQETGSPLLREHLVQACAVSRKVLQLVCLTVAISVRMRVHNSAAHALFAGVAVQLASYPNAEATWRVLLPFVVEFITVGRSTEKLSNSELQEVNEGDESPWIGEDLDGSGVSRFSPSREAACSALVALVAWSNEVKLSSATLRAVVKPIYHLLTTGVDGSASFTVSVVDLLAVLDVLFHTQREAVLDVTFSPQLKFMLSFPWGHWVRFIDSSEARICDTLVSVLLRDCLYRLKSTHSLQSVSSDVLVFVQCAVEFLPLNDALVAETIATLVSCNVEETATMANHQNGENEEEVHLGVKQLQSGRGGSKHGQSSTGRKCVTMWIQALERRFCHVFDTTLSQLLNDVTTQNAAARFLARHLSGARYELLEVRGSSGSTEQLPLFACLLHPVAEVRRFAAERMREMSIGQLTTSSLSTLDGSRGNERGNTLLDLLGHVAQYEQSPEVAMMFLEVAGAASNKLIRVILSSGAGAGETPSRSFSDETQGSGNPVDDAIGILRRLFRCFWTMTVTQGCVAIQERFYQLILLPLMQQVDEQRGVFLGGSKKKLKVPEMGDACRIGWGLLLYYATLLYVHAIDLLVRERSVNGGSAKERLCAGESTDAELTKLVMKLEKHLVETVPGIGRTATLFTPALYPGCDPLYEFADCDASTEGGKSAAAFMGGVTSLLDDEQGEEGFCLSVFECTPLLLALYHEASVQVRPTLERLLCLREANEDDRPSARAIMLECCVGCAALLSTAYDSELADVTHMLFQFFVSGRNGGVRTSKYSIGMRGGYLMNLQGSQRAAAGGMRGRVGRGAANDGSSPFLPKNLFTRIMGATIRISMETRLARNSEVGSCVEGEKMAFNSTNTLAYMGRLLGYLDAPLPAAAVSPMWLPPAYLHMLELCNTASDVAGDDWNVQLPVDWFRLVYRSVFESPVTLKSNCGSYFSLSGLFVAVTSPLAAPAGRREDVLTTLQGLILSAADDVKRSTRDAKKRLTITNMSSAQLFLEAALRQGSISITTLNALVEAIALEDSHAHLTHTASELLCRMIVDGVGNGGNEETTAPFSFLNLVVEHFYPLRARKSGIVVNALLPLLISLLEAGGDGGEGTVSPEAANFVQAICNRAQICAEMATISNEEKNALLQLNLALVRHPFLRVSGRRTRLVYRHALSTFASVLSRGCDVSSANPLVFVPKPTRNTSQGTNNLLEKSDDEDYAKRVASVVSEVVLDDAVCLSRMGADALSLLVGTVGGYQRLFLPLVSQKLKQRSPDLSIIADALEAVAAASPSSPLPGSEGEGGDTVDAWEPPSWCTLYDPLKSTDVESILQLCAKSLSRADGGEEIVWRREGNTLPALRILCAIFESSHLIRFDGDDVGKREGEGGEDLGDSSLFNLVREVLNSFPLASLLPLLEDNDSADVGASGNSLYRLALSFIRCLVNLCLSSPGALNDGQPDGAAVIRQEVVRQSVILMAGLFTPDLPSSSGAQKPASASEAARPNSVFSGRTIGTVTELLRIVSPLFTPAVTPMHSNDFSVGGRVALHIPVVALLIRLESVNFESGKHNYTSAMEVCRHLLVSFDVQTQLLCLTGMMELLVDPHKQLSLSSPKVGGNRRGKVEGMDTGDVGCSENDDDYTMKRLFRKLLKPNQVVNRQEEIMYLINDTIKSEEFLAGFVALQHSTAVLCLDTAHADGGVQRDDTSGTKYGESSLFEGIDKSNECMALLVASLKLFAYYTELNTATENDAGTAAASQHSDGGFVGAPAYGEKKAFVMLLELLAGNTLACVLAGINEPTFVLCMKNLLTDHRAAVQLKGLEMLLDRLHNALPTVEQILTKEEVERGRQKLRDPKSRLTLTDVVRLKARPFATKRSFTLFSHIFALMMSAAGVQVGKAERVDNLRLLTLSVACMEELVRIIASGGSQHAEAALLNVNRTARVTEDRLNKLFGNHSRVEEVHRWVDSMVSVLPRVIRSCRNQDEEHTHGSKEDCLFAAAALLTALGTVSQVMGTAFTVPHSNVTLQVVVDAAVFAAAGVPPTVSRGEVGSVLRQSSLNCLLRTFPSSWLMCQPYLSRIIYVATHLQNVDDTETNYLSVEVMSMLEVALEPQLFIEASAECVRGIVEQEVAADESGKRSKRVLRVRVDTHSLALLYSSIQRRVTSLGREELKHLSLFVGGTTARDNFWLSSMQTLASAPTLPSPDAVQPVLEAYTMFFLKFKAKHCTSFISTMAEWAFGGAAEGFVKSTEKQQAKESAGKESEDVRERDDVASVPRVIVHRWLLFYALCNHLLERLGSIMDFAFPVLLPYIVGTLASYCSSTTHAARHAADLIARTLEGALNSIRIIASAQTAPPHHDHSIPVDNYLATHEVFSAVMPAVVRQLTNLVYLADSTHDYAFRAEQCVIPAVRALFLSLTSSKQQSDTQREVLRSLRHPSRHVRRVALLCLDRIYEDGGGELAARLMAEMLPSVAELTEDRDDVVVEQARRLCGHLSSITGQDVLYAMGS