lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIARLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTSIVISVLLWAYPSNPYVWCVLVVLIGYGIIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLVGKDTPATQLVVPFFKDVMPQLGLFYILLSYFVIVGTGNAVNLTDGLDGLAIMPTVFVAAGFALVAWATGNMNFANYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
The following text describes a protein:
Function:
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSSSFSDDEVWVQVAPQRNAQDQQGSL
The following text describes a protein:
Function:
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MFPLMLGVDGGNDGPMGDGEGPTSALQLTTTILRSHFQALLDILRDANLAFVMSPVPPADESDSWKWTPDSKLCFVTTGATAPFTALIESVLSIPTIETLLADGYTHLLVQYGSAKDVFTKSSHAAHAHLKQAGHEARLVIDGIDFSPEGLQNQFKLVQQSKGLVISHAGSGSILEALRYQIPLIVVPNTALLDNHQEELAVAMERSNYLIRGDVGDLTPAIQKSNDFRVKMAQFPPVTSGKHRETKSFAAIMDDTVGFLD
The following text describes a protein:
Function:
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNDEVKPQHLYLTGYRGCGKSTLAKLLAQKLSLPSVDLDDVIETTAGKSIAEIFANETEVGFRDREEAALMEVSRRPQHVIALGGGTILREANRNIIANSGWCVWLDAEPDVLVARLAGDATTADRRPSLTDQSVFDEVQSVMSHREPLYRASADLRIDTSHRNMDEILTEVLKAAPSSIGQADLS
The following text describes a protein:
Function:
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Subcellular Localization:
Nucleus.
Sequence:
MPSTQTVLRLPVRKAAHLDGKTGSCKKLLSASVCDENDSQQRASRRATKRPSPRKSSTDDDDGGDHRRSDRLRHDASKPGTPGKVPDETDLRQEKYRRVNKKLFSCDEESDAEPSKDGRTPRQQPDSPVGAPLLCLAKADTSLYQKAKRTLTAERDVTIVGRQKEVELIGSFLRRHLEAGSSASMYISGAPGTGKTACLSRVLEAVKATYKFECLFVNCMSLKTSASIYEKILTGLGVPIKGSGHLDAIRARIGDKGRPVVIVLDEVDQLDSKNQAVLYSLFELPRLKGSRAVLFGIANALDLTDRTLPHLQACGSRPDLLHFAPYSKNEIAAILADRLRDCAAVVHPQAVEFCARKIAACTGDVRKALDACRRAVELVERGSRAQQLLVPRPQHGYNPGSPKKLPSLWAVDVAQMARVLAEVLGSRATGGRDLHATLPLQQKLLLCALVATLKKRKQRDVGLGGLQEAYGRICRKQQCATDQMDCQSLCTLLESRGLIRVKRHREQRLCKVALQIDEQEVVYVLQDKALLAACLDDAS
The following text describes a protein:
Function:
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus. Nucleus.
Sequence:
MDFSELPSNIITSLNDLNANLDIVESKYNQFYDRSLSEEHEKMTPLEKAKSEIVAAHTINSLFFIYLQLNGQDVSKHPINYELNRVSKSIARVKEIEDKRLAPKLDISASKRFVKSALWDKDQQAKKPKLDVEKRP
The following text describes a protein:
Function:
Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, septate junction. Note=Nrx is required for its cell surface localization.
Sequence:
MLAKIGLLASILVLNLVGQITPQFSENLPDPDPQSGQQPQNYQPSYNKDYSPRYNPLYTGQQSADPNQFDNTLVDGQSPNTYKGYYDGRAGGGGLGGNVVGPGNNLGGLGPQYDPFNRNSIGSAGVSYRDAYTDEDNFCPEHWVSFRQTCYRFIRSPKRNWAEAKKICKAHNADLINVDNVEKHSFILKNLILQNQRQNRFFISARQTGPLNWVNDDNTQLVQIEDSFSMDEQVPLENEDLHDNRFLVQNDLNNQNINNPNQFYNSLPGTVNQRNQNNLRGFIGPNQPYGDNRYVRDRVVYAFSKKRDRWMFMPAYEIELNLFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERIPRGPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEMNWGKSIFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTRQGLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQMGKTTRNGANTRHGHNINTALILSTLLLISTFLYTSQ
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm.
Sequence:
MDAGKAGQTLKTHCSAQRPDVCRWLSPFILSCCVYFCLWIPEDQLSWFAALVKCLPVLCLAGFLWVMSPSGGYTQLLQGALVCSAVGDACLIWPAAFVPGMAAFATAHLLYVWAFGFSPLQPGLLLLIILAPGPYLSLVLQHLEPDMVLPVAAYGLILMAMLWRGLAQGGSAGWGALLFTLSDGVLAWDTFAQPLPHAHLVIMTTYYAAQLLITLSALRSPVPKTD
The following text describes a protein:
Function:
Putative phospholipase.
Sequence:
MFLSLVNTVLSAETIYKSCSINKTGGVDIVDGKNDALTAWASWEDSIEEVGWYKFHVHTNPKQPSEDQFRCAGALDGYLGQHRIYQRLLLYKDQMNINRTVNFDQKWEDWMEKNLEWTRNQVKANSSDPYWKSVGLILNQFDGLVEGYKLAAPVYEPLRMMDLLFIQSVGDVYDLETYWSKGKIYDEFHHLECTGLITITPDFKELIFGQAAWSSFLKMHQVLKEYEINAPEHPNKHVIISTRMGALASSDDFWLNDNGLMILETTNNNFNQSLYDRITTESLLTWIRVLHATWFSTSGKQWTEEFINHNSGTYNNQYVVVDSKKFVKGQKPTTDLLWVIEQLPGQYKSADLTDILAERRWFPSINVPYFEEIFNTAGYPQKIKDTGEKGDYYSYYNSSRFLIFNRNAPKVNNTDDFKKLIRYNHYLTDEYGHKDPGQQPLSRYDLRDDTCIYGKAAAFGGLDTKVTTSDMMMKNLSIFAIGSPEHDTNAPWSFGEGKFKDIKYDGLPKVWNFSWINYSADSYSRCENFVHEKDCTAVERCGWCAYDLRCYYGAKDGPYDAVCDDGWRYKEPMPDYAIPVIASVSSAMFLIVVGIYIAAFIYSRNNK
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSYNGIGLSTPRGSATSGHIQTNISNRAFQSTNHRGEFAHHEMTDEQDKRLNKKLDRDYAADRQADVELLEHERKRKVEVACMELQDKLEEEGQKGEEEIEEEVNTLRRQLTLKMARELDVRTTIVSADREALRKNYHKAAVIKQQEMDRMRDAFDTTKNLDDRGRDRPRNRQRQNREKSPVRDTRRSRSARERSPSRRGRRPRRYSVTEDVRTSEVISERQGSGSPCRRADSRSRSRSPERGSRRKSYRERSRSRSRERSERRGRRDSVREREQDRSRSPLPY
The following text describes a protein:
Function:
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
Sequence:
MMGIRNEHTIASCCEISGRGYWSGKDVRVTCCPAPAGTGIVLVRADLPGQPECPATTQYATGISFRTNLANGPATFEMVEHLMAALAGLEIDNCRVEITAEELPGLDGSSLAYVDALQEAGLVIQAATSQPLVIRESFRIEHSGGYVDVSPSTNNESTFEYSLDYGPDSTIREQKFRCVQTPLTFARQVASARTFVTAEQAQQLRASGVASHVTHQDLLVIGDNGPVDNQYRFRNECARHKTLDLIGDLSLAGVGLIGQFSSVRGGHQLNGMVAVRLAQLAHQQRLTHHSIPFAGQRRNRAA
The following text describes a protein:
Function:
Transferred from male to female during mating and may affect egglaying and behavior after mating.
Subcellular Localization:
Secreted.
Sequence:
MKITSALVLLFAGVAFAQSADPNTNENKNVIHINSPSAAK
The following text describes a protein:
Function:
Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQAKATDSRQEPTLNMDTNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKIVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSSDWEIEYRGSPGNLLQFEDILFSNKEVLVGNSIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPSIEGEYSAVKTLLDRNGVMITMPKKSGDNDLLQDLNRLLRFAKGQQEDATGLKELQLQLASNALKTAIKYLDLVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDNSTIESVICAPFKSFLKDLTGLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLTQLVTQFTKDIEQLDSDYFKSVLATSEA
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MDIRNEFLQFFQNKGHAVYPSMPLVPNDATLLFTNAGMVQFKDIFTGIVPRPSIPRAASSQLCMRAGGKHNDLENVGYTARHHTLFEMLGNFSFGDYFKEEAILFAWEFVTKNLGFKPKDLYISVHEKDDEAVKLWEKFVPVDRIKKMGDKDNFWQMGDSGPCGPCSEIYIDQGEKHFKGSEDYFGGEGDRFLEIWNLVFMQYERSNDGVLSPLPKPSIDTGMGLERVQALLEHKLNNFDSSLFAPLMEEISELTSLDYASEFQPSFRVVADHARAVAFLLAQGVHFNKEGRGYVLRRILRRALRHGYLMGLKEAFLYKVVGVVCEQFANTHAYLKESKEMVVKECFEEEEHFLETLESGMELFNLSLKHLNENKIFDGKIAFKLYDTFGFPLDLTNDMLRSHGACADMQGFELCMQEQVKRSKASWKGKQNNADFSAILNAYAPNVFVGYETTECSAKVLGFFDSDFKEITDANPNQEVWVLLEKTPFYAEGGGAIGDRGALFKDNGEVAIVLDTKNFFGLNFSLLEIKKALKKGDQVIAQVSDERFEIAKHHSATHLLQSALREVLGSHVSQAGSLVESKRLRFDFSHAKALNDEELEKVEDLVNAQIFKHLNSQVEHMPLNQAKDKGALALFSEKYAENVRVVSFKEASIELCGGIHVENTGLIGGFRIVKESGVSSGVRRIEAVCGKAFYQLAKEENKELKNAKTLLKNNDVIAGINKLKESVKNSQKAPVSMDLPVEKIHGVNLVVGVVEQGDIKEMIDRLKSKHERLLAMVFKKENERITLACGVKNAPIKANVWANEVAQILGGKGGGRGDFASAGGKDIENLQAALNLAKNTALKALEG
The following text describes a protein:
Function:
Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway. Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (By similarity).
Domain:
The PB1 domain mediates interaction with SQSTM1.
Sequence:
MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGYHVVDEALPKNVVENQAAARTGKKPLAHYSSLVRVLGSDMKTTEEPAPEQCSSAPCDTDQPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPLLSSSPTEVSMPISEETLFLPENQFSWHIACSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYTHDTNHVLLKLRRPVVISSEPFFYSKYSAPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWNTDTKLKFMWGNLTLASTEKKDVLVPCLKAGHVGVVSVEFIAPTLEGTYTSHWRLSHKGQQFGPRVWCSIIVDPFPSSESPDNVEGDRISSSKADDFSCEQEEAFLLAEEEIPLGEVTKQTEGTGASASQKTRRAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDMTPCMSPLPHDSPLIEKPGLGQIQEESEGAGFKAPPDSTVSAKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEGQQPLVLPGFCRKDSSLKFALPEEGPRGDEREEIVHIVEEEVVEEEEEVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGLEPTEARERLPERESQPQEQSISDILTTSQPLDTVPLVPEVAGLPAALSRSAPCGQCESSGVDSPGVDSPATMHEVPPAPDDIRGEPRGSTGLANSRQRSCDHSRHHNGSSIAGGLVKGALSVAASAYKALFSGPPVTAQPIVSEDQTTALMAHLFEMGFCDRQLNLRLLRKHNYNILQVVTELLQVNNNDWYSHRY
The following text describes a protein:
Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MKKGVRGKKEPFAAQRIQSPNGIMFQAARVMQFSSSARAADENFDYLFKVILVGDSNVGKTCVVQHFKSGVYTEAQQNTIGVDFTVRALEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESVPHWIHEIEKYGAANLVIMLIGNKCDLWEKRHVLFEDACTLAEKYGLLAVLETSAKESKNIDEVFVLMARELIARNSLPLYAEGALSSLPLDSSPVLTVSPREKTQCTC
The following text describes a protein:
Function:
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges.
Domain:
The C-terminal 30 residues are probably required for function in DNA repair.
Sequence:
MDQKILSLAAEKTADKLQEFLQTLREGDLTNLLQNQAVKGKVAGALLRAIFKGSPCSEEAGTLRRRKIYTCCIQLVESGDLQKEIASEIIGLLMLEAHHFPGPLLVELANEFISAVREGSLVNGKSLELLPIILTALATKKENLAYGKGVLSGEECKKQLINTLCSGRWDQQYVIQLTSMFKDVPLTAEEVEFVVEKALSMFSKMNLQEIPPLVYQLLVLSSKGSRKSVLEGIIAFFSALDKQHNEEQSGDELLDVVTVPSGELRHVEGTIILHIVFAIKLDYELGRELVKHLKVGQQGDSNNNLSPFSIALLLSVTRIQRFQDQVLDLLKTSVVKSFKDLQLLQGSKFLQNLVPHRSYVSTMILEVVKNSVHSWDHVTQGLVELGFILMDSYGPKKVLDGKTIETSPSLSRMPNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTRASSPISHFLDLLSNIVMYAPLVLQSCSSKVTEAFDYLSFLPLQTVQRLLKAVQPLLKVSMSMRDCLILVLRKAMFANQLDARKSAVAGFLLLLKNFKVLGSLSSSQCSQSLSVSQVHVDVHSHYNSVANETFCLEIMDSLRRCLSQQADVRLMLYEGFYDVLRRNSQLANSVMQTLLSQLKQFYEPKPDLLPPLKLEACILTQGDKISLQEPLDYLLCCIQHCLAWYKNTVIPLQQGEEEEEEEEAFYEDLDDILESITNRMIKSELEDFELDKSADFSQSTSIGIKNNICAFLVMGVCEVLIEYNFSISSFSKNRFEDILSLFMCYKKLSDILNEKAGKAKTKMANKTSDSLLSMKFVSSLLTALFRDSIQSHQESLSVLRSSNEFMRYAVNVALQKVQQLKETGHVSGPDGQNPEKIFQNLCDITRVLLWRYTSIPTSVEESGKKEKGKSISLLCLEGLQKIFSAVQQFYQPKIQQFLRALDVTDKEGEEREDADVSVTQRTAFQIRQFQRSLLNLLSSQEEDFNSKEALLLVTVLTSLSKLLEPSSPQFVQMLSWTSKICKENSREDALFCKSLMNLLFSLHVSYKSPVILLRDLSQDIHGHLGDIDQDVEVEKTNHFAIVNLRTAAPTVCLLVLSQAEKVLEEVDWLITKLKGQVSQETLSEEASSQATLPNQPVEKAIIMQLGTLLTFFHELVQTALPSGSCVDTLLKDLCKMYTTLTALVRYYLQVCQSSGGIPKNMEKLVKLSGSHLTPLCYSFISYVQNKSKSLNYTGEKKEKPAAVATAMARVLRETKPIPNLIFAIEQYEKFLIHLSKKSKVNLMQHMKLSTSRDFKIKGNILDMVLREDGEDENEEGTASEHGGQNKEPAKKKRKK
The following text describes a protein:
Function:
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Subcellular Localization:
Cell junction, tight junction. Lateral cell membrane; Single-pass type I membrane protein.
Sequence:
MARPQVLACGLLLAAATAAVAVAQRACICENYKLTTNCSLNINNQCECTSIGAQNSVICSKLATKCLVMKAEMTGTKSGRRARPEGAFQNNDGLYDPDCDEKGLFKAKQCNGTTTCWCVNTAGVRRTDKDTEISCTERVRTYALKETLKNRYQLDPKYITNILYENDLITIDLMQNSSQKAQNDVDIADVAYYFEKDVKDESLFHSSKMDLRVNGEQLDLDPGRTAIYYVDEKPPEFSMQGLQAGIIAVIVVVTLAVIAGIVVLVISRKNRMAKYEKAEVNELLYFKNPFLIFTPDNHCTFLDTDRTQLYWSPFIVYSP
The following text describes a protein:
Function:
Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity).
Miscellaneous:
MISCELLANEOUS: Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MAKATTIKEALSRWEEKTGQKPSDAREIKLYAQIPPIEKMDASLSTLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHVMRKLKILYISNNLVKDWAEFVKLAELPCLEDLVFVGNPLEEKHSAEGNWIEEATKRVPKLKKLDGTPVIKEDEEEES
The following text describes a protein:
Function:
Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1.
Subcellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein.
Sequence:
MTNIREDENIFMFLCEKWILINKNHIWNRINQRINIIADFDRYQRARTISEGQRTENIHRNIYGAVPYDYNLVNLTSTQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDFMAFYNTMKEVGVPLLAVMKNNCMSSFFKKYHHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQLRHLEKYLEAHANTVRMIDSTNTEDVDKFIKPRDWIVDFDERDRLIGKLQFRKRLKIEKDQVSEQKLVHLKSQLHLFQDTYKYESYVLQ
The following text describes a protein:
Function:
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
Subcellular Localization:
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Sequence:
MISDKIKLTAKDILEKEFKTGMRGYQQEEVDKFLDMIIKDYEAFHKEFEQLKQQNARLKRELEEQKLAVTQVPQQPVQTPVAQPVYNNTNTDILKRLSNLEKAVFGSKLYE
The following text describes a protein:
Function:
A 5'-3' exoribonuclease with a strong reference for 5'-monophosphorylated RNA and no endoribonuclease activty.
Sequence:
MVLLKFHGGCQQIGMSCVEVETQKGRVLLDCGMSPDTGEIPKVDDKAVDAVIVSHAHLDHCGAIPFYKFKKIYCTHPTADLMFITWRDTLNLTKAYKEEDIQHAMENIECLNYYEERQITENIKFKFYNAGHILGSASIYLEVDGKKILYTGDINEGVSRTLLPADTDIDEIDVLIIESTYGSPLDIKPARKTLERQLIEEISETIENGGKVIIPVFAIGRAQEILLIINNYIRSGKLRDVPIYTDGSLIHATAVYMSYINWLNPKIKNMVENRINPFGEIKKADESLVFNKEPCIIVSTSGMVQGGPVLKYLKLLKDPKNKLILTGYQAEGTLGRELEEGAKEIQPFKNKIPIRGKVVKIEFSAHGDYNSLVRYIKKIPKPEKAIVMHGERYQSLSFAMTIWKTLKIPTFVPVRGTILPI
The following text describes a protein:
Function:
CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.
Subcellular Localization:
Endoplasmic reticulum. Nucleus. Note=Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus.
Sequence:
MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKSKRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKTRHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDNYVRDFKALIDWIQLQEKLEKTDAQSRPTSLAWEVKKMSPGRHVIPSPSTDRINVTSNARRSLNFGGSTGTVPAPRLAPTGVSWADKVKAHHTGSTASSEITPAQSCPPMTVQKASRKNERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLLPDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHILQAVVPATNVNTVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLTVYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPFNNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKENYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQAWEEARQFFLKKEKK
The following text describes a protein:
Function:
Involved in rRNA-processing and ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MRVKRRSRHRKVVKFYSTCFGFREPYKVLIDGTFVHHLLVHKLLPADDALRELLSASRAPPLLTSKCVVAELRRLGKSHSEAFDAAQLVATASCEHDKVVSAVDCILSLVGDKNPEHYFVATQDSGLRAKLREVPCVPVIYGLKNSLFIEQPSVQQRQFAQLDEEKRIHMEKSEFKKLLKASSEGKTSINGNTPGVVEKSKFKRNRAKGPNPLSCKKKKPKPQPSAPQNQGPKTDGDAKRKRVRKRKRSAKGSSQAETAS
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MAIATLFCVLFICMFLGMPIAIALGFSSMLTILFFSNDSLASVALKLYESSSEHYTLLAIPFFILSSAFLSTGGVARRIIDFAMDCVGHIRGGLAMASVMACMLFAAVSGSSPATVAAIGSIVIVGMVKAGYPEKFASGVITTSGTLGILIPPSIVMLVYAAATEVSVAKIFMAGLVPGLLLGFLIMVVIYIVARIKNLPSIPFPGFKKLGVSSAKAIGGLALIFIVLGSIYGGVASPTEASAVACVYAYFIAVFGYRDIGPLKNVAWRNPNEAIPSAIARNLGHMVLGLIKTPIDKEIRHVVRDGAKVSIMLLFIIANAMLFAHVLTTERIPHIIAEYIVGMGLPAWGFLIIVNLLLLAAGNFMEPSAIVLIMAPILFPIATQLGIDPIHLGIIMVVNMEIGMLTPPVGLNLFVTSGITGRNIGWVIQSVLPWLVFMLAFLMLITYVPQISLFLPELLDKLNGY