lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in cell wall, plasma membrane, and cytoskeletal organization. Plays a role in endocytosis and hyphal morphogenesis. Required to restrict septin proteins to the bud neck and prevents intracellular growth of cell wall. Contributes to secretion, biofilm formation, and macrophage killing. Essential for resistance to stressful conditions and for invasive growth and virulence.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.
Sequence:
MKVVFTFFNLFFLAGTVLLLIFTVLSGSSKHFPLNKFYWLEADTSGIKNAPANRSAWTFWGVCDKADYSNCLLGPAYPISPEDNFGTTADIPKDFVDNENTYYYLSRFAFAFCLIALAFSGLAFIIDILGFCFEIIDKVVIFLITIGLLFLAGFASLQTAVVVLAKNAFKNDGRYAHIGAKSMGIMWAAFACLLICWLLIFAGTISNSYKKHIARVKAEQGQYSQPTHGPAGDESSFTRAAPPTKDEENTGGIRFFKIKRNQKVSDDESV
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MLSNRTLTEEQTLIRRHFIDFFESERYEEKYHQLVQEMMAASGSRLLLDMGDLLDFTPTATGFDTTAGLGLNQSASLGACIIREPGKYVPLLELALHDVVLRQQPEYLKVDYRSRAVHVGFEGPVGTVRSPRELYAQHLNTMVALEGIITRQSSNRPRVLETVHYCPETNKFSRKEFRDQLTPMIDSRHLPTVNVMPKTDMEGNVLRTELGLSTFMDSQCAILQEAPERAPTGQLPRTVELRFDDDLVDIVKPGDRVTLVGVYMAYTTSDNKSFQSIVLVNHVIPVQAFTMYRRVPSIEEKLFAFAAKCTQTDGPAGVLNSLSMAVAPTIYGMTNERKAVLLLMVGGVERVAHQSHVRGDINVLLVGEPSTAKSQLLRFVLGVAPLALSTTGKGSSGVGLTAAVSIDAYTGERSLSAGAMVLADRGILCIDEFDKMSAQDRVAMHEAMEQQTVTIAKAGIHASLNARCSVLAAANPIYGFYSVHHRLAFNVGLPESLLSRFDLTFIVLDKHSSEHNRRIGRHILRNHMTAEPVEIDQNITKTVVDSVDSVWAQSGRQGGGAGGGLDFRMTTTSSGETIVGVDFLRAYVQLAKLGRPTLTEASQQLVSQHYVQLRAEQQEGSKDGFFVTARTLEAIVRLATANAKLRLSSTVDEDDVKSAMELLRASVHAATAASQQRAEDNKATAMEKRQGAKRSAEGLTNGAGVDIISGAGNTRRQRQEVEETAAGAVASPAEEMALTTAESSKEITLSRVSNMLRLIQRQDRQPAVRLSDVHARLGGSLSMEELRQAVSELQGDSFVYEAIGEDEWVQFI
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity).
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MGLKLLHPPKPYAMTSDPESYASVCVMKKWPIIATNVIDEVSRNISKALEAGMSDKAAYVTQGKEIISLLNQLKYDLQHNRPLKPLVGQGPDIDDYNEELEQVGPLTWGDAPWLYAGCYFYRIMSLFFQARSEWNRHDPFFEQKDFTLRSSKSAIEEFAKRYVHLNSELASIQENKDDKAAYMIFVEMAEISLWGNAIDLGLLVNATYEQLQSLQGQKAVEESQKNILVNDFPKIWSKLSKVRHGRIDFVLDNAGFELFVDLLFATYLLKTEIAETIILHPKDVPWFVSDVLVNDIPHLFNSLTSYFSGEGVQKLASDLAEFHAEGKIVIRPNPFWTTAHYFGRLPDVAPKLLSDLEQSDMVIFKGDLNFRKLTGDCEWPHTTPFAEALGPIAGKFNILALRTIKADVVVGLGKGVYEEIAKDNPHWERTGKYAVVEFCPKD
The following text describes a protein:
Function:
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MNYTGYLLAFQLCIILGSSSCYCQADLFKEKYKLRNIFNASDSDVADGGLFLDILKNWKEESDKKIIQSQIVSVYFKIFDNLKDNQIIQKSMATIKEDLIAKFFNSSSSKLNDFPQKLIRTPVNDLKVQRKAVNELFKVMNXDLSPKSNLRKRKRSQSTFHGRRASI
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSGSGHDQSTDIFSADGRVFQVEYACKAVDNGSTAVAACCKDGVVVAVEKILTSRMLEEGSNNRIHAVDRQAGICVCGVLPDGLAVVSRARGEAENSRDIFSTPILGSLLASRIGEFMHVYTTHYAYRPFGCSVIIASYADDGPQLYVADPSGAVAGYYGIALGKGKTVAKTELEKLDFATLTCSEAVEKLTNILHEVHDKSKDKIYEVEVAWVCDKSDRTFVHVPKEMVPHPTPAS
The following text describes a protein:
Function:
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Plays a role in outer and inner dynein arm assembly.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Localizes predominantly in the cytoplasm and weakly in flagella. Transported to the flagellar matrix in an intraflagellar transport (IFT)-dependent manner.
Sequence:
MTAFVPVSLPSTSALNDAYVKSQLTKWDLLRNLRCVAVRYTKYYHKLQGQELLADLFRDEKVQEAFQVLRKGGAWGQLGGPVTKVDATLLASSLTRMDLFDKLTETSPPIVRSNGDIGKCMEDNREGFQVSDQLRELILVEESEHAALFSEAERDELLWRLFEHVVLGGACCQFEDKVEPYVETSKRLYKELVCAQKDPATGKVQTVSAVYKINSIQGDSGPLELYPSRSRQNFCYAAVDPVRRIVKILYHAYVPYW
The following text describes a protein:
Function:
Bifunctional enzyme involved in flavonoid metabolism.
Sequence:
MASEAHAAVHAPPPVAPTVCVTGAAGFIGSWLVMRLLERGYNVHATVRDPENKKKVKHLFELPKADTNLTLWKADLSVEGSFDEAIQGCQGVFHVATPMDFESEDPENEVIKPTVRGMLSIIESCAKANTVKRLVFTSSAGTLDAQEHQKLFYDETSWSDLDFIYAKKMTGWMYFVSKILAEKAAMEAAKKKNFDFISIIPPLVVGPFLTPTFPPSLITALSLITGNEAHYCIIKQGQYVHLDDLCEAHIFLYEQPKAEGRFICASHHAIIYDVAKMVREKWPEYYVPTEFKGIDKDLPVVYFSPKKLTDMGFQFKYTLEDMYKGAIETCRQKQLLPFSTQSTADNGRDKETIPLSAENYASGKENSPVANGTGKSTNGEI
The following text describes a protein:
Function:
Not essential for flagellar formation and function.
Sequence:
MRTLLAILLFPLLVQAAGEGMWQASSVGITLNHRGESMSSAPLSTRQPASGLMTLVAWRYQLIGPTPSGLRVRLCSQSRCVELEGQSGTTVAFSGIAAAEPLRFIWEVPGGGRLIPPLKVQRNEVIVNYR
The following text describes a protein:
Function:
By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed.
Miscellaneous:
MISCELLANEOUS: The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MNKKTRQTLIGLLVLLLLSTGSYYIKQMPSAPNSPKTNLSQKKQASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIVNGNKTNLDAKVSSKPYADNKTKTVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGHLLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRVRYRVTLYYASNEDLVPSASQIEAKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ
The following text describes a protein:
Function:
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (By similarity). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
Subcellular Localization:
Cytoplasm. Synapse. Nucleus. Note=Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). Enriched at synapses.
Domain:
Binds three actin monomers via the three C-terminal RPEL repeats.
Sequence:
MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEDDSLTNGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVLICMPVGGPELSLASYAAQKSSQQAVAQHHHTVLPSQMQHQLQYGSHGQHLPSSTGTLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSSDGVTKAGPLGLPEIRQVPTVVIECDDNKENVPHEPDYEDSSCLYAREEEEEEEDEDDDASLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP
The following text describes a protein:
Function:
Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.
Sequence:
MVFTFGIWDGWHLKSNIMAAPCVPHVQEMLRETGHCALFYKDNGLETLSAVVLSLQKYAEASVKRCKDKHLEEAFRHLGSTENVLGTLSDAEVCPLIKCVVACQTEACHSTSLFQKLEKMIAKLSEVRPGLVSQQVESLLSQLFQRKETGDENYQVLHVKDLQTVCMYLEGSYMGRKYFKQHLHLLLSKVSATFSLLLQNQAKQREDSCYLTVKVCLQMFRELGEDITPLVWIPACTTSPLQSIFSSLLKVITSQNVCPDTRLLAGTAVASLAIIGPDAVLGAHACLTLMQQLRKESYEQIRFGELHVSITRPLLDELSLVVLLRGLLTCSSADLLTSELPAFNQNKTTLELLLPFVVSVCEGKKEHYYSFQVFCLWLQRLRELTAHILKVRGICALAADQESLCLVTRLLWSGAEMQVDGMSDLVLSCFQHFFHIYHTECQFLGLPVEPMFQEMLKKITEISWQSRSRYIPLCALLPFIGPKKVLEFYPELPTDLFRCLCINYLCPPAAETYRVFISLQHAEWSRNGQQDEKEMARLWAINWLAPLCDALTSIKRSLQTNSATYFLPCTLRCFPGSTALLANHLQSSDPTEMRGWVSLLQCQKIVLGSVTDEINVKLQLCLESGDDGVRLSALNFLCCSPRSCQPPAPHELKMIKKFLPFNLGCDSPGFRQQLQAVLKKVTERLRDVALAALRKKRTKEEEISQVVDFVEWLLQLSVSSLSPAGNYQRCCSGLLLLSGLLESCTDSWTPQRKKGQPPSDMPVLLNYAREKGCWDFFSPPNMQALLGCMQDSTNEIRELASDLLVRFFPAAPESLTLAMFDLGQEFICSPRVSVAEAGALLLKTVMQRLDRGLPFPSDAPCSAMSFIIYLTNKLEDHYHCAQKNMLHAATCKPLHGVLSALRLCLLDVPSVKKSLSDPDLADRWLCLFEDLVSSLKDITSFILSVLYGTHGEEGSEAAAPSFADMGKAVSALIAQGQGLDEVRGDVFLSEEHSLIMTCCWVSLKEIGLLLGPLVEKLICGQTALLSTSAVHKSVEMYQDICFRCRHWGAVDGCSAGFTRLCSVLLNHEDPTLRAIPKDMIEQALARCRSQNSLSVTRRAAGFPVLLQCILCAEGTLQPLLTYSVQNLLELAQEPLPSHWDQTRDLPQVAAVHALQTLMRSAGLRSSLLVYAVPLMSLALCSLRSPCWAMRNAALQLFSALTSGILGISRSDADSSVQSTLSLGTLLRRFPGMQDVLLKELGTAQHADKMLHPSVHPPLALLAKLQAGGDNDASCFLDPLLKLAGNPIYAVRVMAARALVPVVQVMNYHALLLQLVGKLPQDNESVSHNSLHGNLLQIHALLVPAVKERCLTQDVREMVQQKLLAVLWLLSPAQKCPLVRAAFLDILSVLVPSCGKDFARLVREAILNTLKVQSLEVGSAVFHDACVAYLCNEAASSSDATFYPHVIFFLRAGEPAALKWVNEYRECDLPLNLARIVRDTLQAMLCSKLLSEDPSAGLMLYLESFVHIHTTCTQLADLPPSETPDMQCIHVLLSLLESHKVTPQLRSCALSTVGLLLKHWSMKDIVSLVSIWLSAIFRCANVSCEKLRLGAAQALQLAGTQLVRLALNEREPSVTSLAVRAIACGVDLLQDEDRSVREAAAKFAASVLGHPAKLTMQSNWALLHLFKLLSESFQDSEESLNALLLRLPPFDVDAALSSLSERSVNLYEEDQPNVFADSRQLTLLLLPQISSIMNSASLSSAVLPWIASTLAPLRQQIQRCLHWCTEQGSISQLWLKASGCPRLHVAVLGLLVRSELVLKALQTLSKSEVLVTNLDISLSCLKDELSELRAQLTLHGIGLNVESL
The following text describes a protein:
Function:
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
Sequence:
MAKWKCIVCGYIYDEDEGDPDSGIAPGTKFEDLPDDWVCPLCGAPKDMFEKIE
The following text describes a protein:
Function:
Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.
Subcellular Localization:
Nucleus.
Domain:
Homotrimerization occurs through formation of a three-stranded coiled-coil structure generated by intermolecular interactions between HR-A/B regions allowing DNA-binding activity.
Sequence:
MPPTNGEGGSQQPQQQQQQQQQQQQQQQQQQQQQQGGSGSSDFVRKLYKMLEDPSYHSVVRWSDDGDSFVVLENEKFTKTILPKHFKHSNFASFVRQLNKYDFHKVRHNDENGESPYGRDAWEFKHPEFRADRKDNLDNIRRKAPAPRKQQQSEEAFNASQQQIAALSESLQATQQQLQALQQQCYELEKTNRLLVSEVMTLQKMVKAQNQASNEIINHLGSMEDRRRNNRGATQAAPNFHAGAMSFLTDGAEEPAPELRRARELLSVVGPDLQANRELERLYMTYNQNGAPAEPAATNSSAVMFTQAAAPGTQATAPGMPLVHNPLNDPQNMMYPVAQTPSIDPSFHTDQMHNMPYSRPLSNPAVVAETSSSQITPSQITPPPKDQMSSMWRDKKPRVLLVEDDKTCARIGAKFLSTLDCGVDTAGDGLEAVERINQDSTRFDLIFMDIIMPNMDGVSATAMIRMVSPHVPIIAMTSNIRGEDINTYFQYGMNDVLAKPFTRDNMSRLLRRHLAHLLKDPQSAASTGIVLTTDDLTLAGQTAGPATTGVGVGVAGAPSGGAHGPGPPAQHQQGYAMAPPTTMQPAPPQVKFEQSPTAAPAPGLDPSSAAAAPTWQSTNPAGVQLQPPPPPTPTQPSPTSAAPPAGLDPASAVAAAAAAAAAAAAAAASMTPGGYLAAAPPPPPPPGAMVLTPAGTPTGVGHPAPSGAGSAAGARGPPGPGPVGPGSVVDDSRPEKRQRLMQGGYASVSGHGHGHPGVGVAGFVQ
The following text describes a protein:
Function:
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.
Subcellular Localization:
Lysosome membrane; Peripheral membrane protein. Secreted.
Sequence:
MNVKTTICCVLLLLFSTSSAKDVDLRVKGVTSIATTDENFICATLDWWPPNKCDYNDCPWGNAGILNLKNDGLFGFSKGCLPKKKWDEINHFFNKTGVKLTFGLNALSGKKPSKEDKKNWKGDWDPTNAIDLMEYTISKGYNIDSYELGNELCADGVSARIDSVQYAKDITQLRKTVNLLYQDANTRPKVLGPAGFYGKEWFDSFLQNVGHGVVDGVTHHIYNLGSGNDKDLINKIQDPYYLSQVAQTFKDVSDAVKEFEPSSGPWVGESGGAYNSGGKDVSNTFVNGFWYLDQLGMTSTFNHKVYCRQALVGGNYGLLDTTTFIPNPDYYGALLWHRLMGSKVLSVSHEGSPYLRAYVHCSKTESGIAVLLINMSNSTTFEVSLLNDMNLYPEVVFKNTQREKYHLTPQRWYLDQLGMTSTFNHKVYCRQALVGGNYGLLDTTTFIPNPDYYGALLWHRLMGSKVLSVSHEGSPYLRAYVHCSKKESGITVLLINMSNSTTFEVSLLNENLYHPEVGLRNRNTPREEYHLTPKDGNIQSKVVLLNGTPLVLTQSLHIPEMNPKLVDPSSPIKVKHDSIVFVHSKSFNAPACM
The following text describes a protein:
Function:
May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDEEVENKVILHGSFASPYSKRIELALRLKSIPYQFVQEDLQNKSQTLLRYNPVHKKIPVLVHNGKPISESLFIIEYIDETWSNGPHILPEDPYRRSKVRFWANYIQLHLYDLVIKVVKSEGEEQKKALTEVKEKLSVIEKEGLKEIFSDTDGEPTVTNETMSLVDIVMCTLLSPYKAHEEVLGLKIIDPEIVPGVYGWINAINETSVVKDLSPPYEQILEILRAFRQMSLSPVLETYQS
The following text describes a protein:
Function:
Probable transcription factor.
Miscellaneous:
MISCELLANEOUS: Assigned as a member of the MYB-related gene family, I-box-binding-like subfamily; MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
Subcellular Localization:
Nucleus.
Sequence:
MASNSRSSISPWTFSQNKMFERALAVYDKDTPDRWHNVAKAVGGKTVEEVKRHYDILVEDLINIETGRVPLPNYKTFESNSRSINDFDTRKMKNLKI
The following text describes a protein:
Function:
FliN is one of three proteins (FliG, FliN, FliM) that form a switch complex that is proposed to be located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Sequence:
MSDMNNPADDNNGAMDDLWAEALSEQKSTSSKSAAETVFQQFGGGDVSGTLQDIDLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVADKYGVRITDIITPSERMRRLSR
The following text describes a protein:
Function:
Required for micropylar pollen tube guidance. Plays a role during early embryo patterning.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MVAFRFVYIPLPFFFFFFFFFVFFSGVSQLQDQTATKKSVRILSKILIGDDGRVYACSDNDFFSFESNGSIAWSVHMNFKCNTDFAPVYSGFNQMLLLAENRILRVIFPRNGTKSEPELFFDPGETILGFAVSVSSSSVYITVKNHGLYAYNMFRQQLWIAEPKIERFGYRLGCRKDFDNCTFNSRPVIDSCEGSIYISNNEGELYSLSLRGTYYQWIQDFSLVDRFFTVTPGNNGLVYVVFPIKSLVFALDSFSGDILWQKTIGPLAETSASDPVIDSNSWASIGSLDGTLYSFSRTGDLYKIPKNAETDSVIQIEPLLDCSGYAVYVSQTKFEGMIDRVIEDYTYVSAKKPETAVFSLVVPETRSIYWSQSYSDQIPGLLLDEDLQHFVLDERIALAFVAASSSGNPFRCRSKHEKLSSSCSFAEPEHLDIYIGNERAIIWFLLFEFVIMVLFAALVRFCFIFWKKKKLQDRPFSTFLDKRRLLHRKSREIDKTITRLQNESTANESAVDKIGDLIQKRENVKRKLSSTYSLGRDIDESKSKLKDYVLPLYGGSSRSFSYRNRENESITIFQTPSDESSSEESYRDEHYDDVADDEHDEDDLDRKQKGKLLAHSEGSSNDGDGIASSRRSIYLKHIFDD
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTRVLKVDPLFPDEKVLKEAAELLRNGEVIIFPTETVYGIGADAYNEEACKKIFKLKERPADNPLIVHIHSFKQLEEIAEGYEPHLDFLKKFWPGPLTVIFRKKSEKIPPVVTADLPTVAVRMPAHPVALKLIELFGHPIAAPSANISGRPSATNVKHVIEDFMGKVKLIIDAGDTPFGLESTIVDLTKEKPVLLRPGPVEVERLKELFPELVVPDFVRKGNFKGRPLAPGMKYRHYAPLKPLILVEDLTKMEEVLKKYPDHVVICVEERKELYDDRIVVGSLKNPYSIAQNIFSALREAEKMGKEYIIVEGFEERGILFAVMNRLRKAATEIVR
The following text describes a protein:
Function:
May be involved in drug clearance in the placenta.
Miscellaneous:
MISCELLANEOUS: May be involved in the development and/or progression of nosopharyngeal carcinoma.
Subcellular Localization:
Basal cell membrane. Note=Syncytiotrophoblast in placenta.
Sequence:
MSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKDEWTEVDRKRVLNDIISTMFNRKFMEELFKPQELYSKKALRTVYERLAHASIMKLNQASMDKLYDLMTMAFKYQVLLCPRPKDVLLVTFNHLDTIKGFIRDSPTILQQVDETLRQLTEIYGGLSAGEFQLIRQTLLIFFQDLHIRVSMFLKDKVQNNNGRFVLPVSGPVPWGTEVPGLIRMFNNKGEEVKRIEFKHGGNYVPAPKEGSFELYGDRVLKLGTNMYSVNQPVETHVSGSSKNLASWTQESIAPNPLAKEELNFLARLMGGMEIKKPSGPEPGFRLNLFTTDEEEEQAALTRPEELSYEVINIQATQDQQRSEELARIMGEFEITEQPRLSTSKGDDLLAMMDEL
The following text describes a protein:
Function:
[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
Subcellular Localization:
Secreted.
Sequence:
HSDAVFTDNYSRFRKQMAVKKYLNSVLT
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLLKFMYIYGIGCGLMPAPLKKGQFLLGYKQRWYLIYTACLHGGLLTVLPFTFPHYMYDDSYMSSNPVLKWTFNLTNITRIMAMFSGVLLMWFRRKRILNLGENLILHCLKCKTLDNRSKKYSKLRKRVRNVLFQMLLVANLSILLGALILFRIHSVQRISKTAMIVAHITQFIYVVFMMTGICVILLVLHWQSERLQIALKDLCSFLNHEERNSLTLSENKANRSLGKLAKLFKLFAENQRLVREVFRTFDLPIALLLLKMFVTNVNLVYHGVQFGNDTIETSSYTRIVGQWVVISHYWSAVLLMNVVDDVTRRSDLKMGDLLREFSHLELVKRDFHLQLELFSDHLRCHPSTYKVCGLFIFNKQTSLAYFFYVLVQVLVLVQFDLKNKVEKRN
The following text describes a protein:
Function:
Catalyzes the transamination of p-hydroxybenzoylformate to L-p-hydroxyphenylglycine as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics.
Sequence:
MEILVFMDSYGLSTQLSMETLHGSLTDPAISSMNLLNELIDEYPVAISMAAGRPYEEFFDVRLIHEYIDAYCDHLRHDRKLAEAVVTRTLFQYGTTKGIIADLIARNLAEDENIDAAAESVVVTVGAQEAMFLILRTLRADERDVLLAPAPTYVGLTGAALLTDTPVWPVQSTANGVDPEDLVLQLKRADEQGKRVRACYVTPNFANPTGTSMDLPARHRLLEVAEANGILLLEDNAYGLFGSERLPSLKSLDRSGNVVYIGSFAKTGMPGARVGYVVADQRVAGGGLLADQLSKLKGMLTVNTSPIAQAVIAGKLLLNDFSLTKANAREIAIYQRNLQLTLSELERTLGGLPEVGWNTPTGGFFVTVTVPFVVDDELLAHAARDHGVLFTPMHHFYGGKDGFNQLRLSISLLTPELIKEGVTRLAALITARLRWPRA
The following text describes a protein:
Function:
Mediates sugar transport across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MDWGVVEIVSFVATVTNVLLFLSGIQIISKIYTRGSSQGFSVLPFIVCFVSSTLWTKYGLLSEDSIMILVNFIGVVIEGFYTAVFYLNTKQKQKKLQMTIFSLLAFMFAVLIYTKYFVNQDLALKHHGFICAAFNIINYAAPLSSAAVVIRKKSTENLSLLLSVVYFLVSVEWFFYGYLHQDNFIMIPNTLGILFCSFQLSLFVFYPSKRTISDHKPDIVTF
The following text describes a protein:
Function:
Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Can also reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide (By similarity).
Subcellular Localization:
[Isoform Mitochondrial]: Mitochondrion; [Isoform Cytoplasmic]: Cytoplasm.
Sequence:
MNLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGVRILAFPCNQFGKQEPGSNEKIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
The following text describes a protein:
Function:
May be a cell surface adhesion protein.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MPVTAGAPSTLVALFVTAVVLAATSAPACYAAHNITAILSGRRDLAEFSRELAATGLADDINGRNTITVLAVDDAHMAPLKARGLPRETLRHVLSLHVLVDYYDDAKLHRLPGGSADVSTLFQASGDAPGSAGMVKVAERRGGRVAFVPQDDDAGSTAVFYVRSVHETPYNISVLQVSGVISSPAAEAPAATADPSRRNVSDVMSKNGCGRFAGLVATTGDAAATFEKKAHDDGGFTFFCPADKAVEAFQPTFNRLSADARLAVVLYHGALGHYSMQALKAGDQDLGTLASLDGGNSNFDFAVRNVRDKLTLVSATHNVARVTRTLAYEEDVAVYMIDAVLVPCDLTAAQGTGGTEHGELSSGSDGRSGGKDGGGGHQTSGSTASAPTPCWLPREWFATSALLFTLLAAFASG
The following text describes a protein:
Function:
Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator. Also represses its own transcription.
Miscellaneous:
MISCELLANEOUS: Neither GlcNAc-6-P, GlcNAc, anhydroMurNAc, MurNAc, nor muramyl dipeptide have an effect on MurR binding to the operator site.
Sequence:
MLYLTKISNAGSEFTENEQKIADFLQANVSELQSVSSRQMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALLDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHFTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK