lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Sequence:
MASSPRPTTPNSQKKRSGRRQSHRSSGAYNILPQSPKIHYPVDPDNLPLEAPGNTEKFESLSDALEELDVNMTNLQSIHEAISDGFNESFASFLYGLSITMWCVDFPGCPSRNQWEKLKLVEGLDDRISELAEKIRSHREENERLKNRLASNVVESTEEVENHSDSHENRKPQHSHRVGKGPTRQVDEGDDTYMTNEGSFVVNPSAPSATRIPQPVKTAPRRFTKHTPPPPPPPPPADTSMHSSYRGPNLNQPPRYMRGLFDSTNRPTTPSNNRSKRVANPNRIQKATGRPPFR
The following text describes a protein:
Function:
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform 1; MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform 2; MISCELLANEOUS: [Isoform 5]: Produced by alternative splicing of isoform 1; MISCELLANEOUS: [Isoform 6]: Produced by alternative splicing of isoform 2.
Subcellular Localization:
Nucleus.
Domain:
The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.
Sequence:
MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE
The following text describes a protein:
Function:
Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Concentrated at cell-cell borders. Localizes at membranes in a microtubule-dependent manner.
Sequence:
MVADIKGNEQIEKYSWREACDTGSSRMDRKHGKYILNVEHSENQPPITHPNDQEAHSSICWCLPSNDITSDVSPNLTGVCVNPGILAHSRCLQSESCNTQVKEYCRNDWSMWKVFLACLLACVIMTAIGVLIICLVNNKGSANSSIVIQLSTNDGECVTVKPGTPSPACPPTMTTTSTVPASTATESTTSTATAATTSTEPITVAPTDHL
The following text describes a protein:
Function:
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
Sequence:
MTETQFGGDEYDVSVSVSEAAVERALDVRPADVAPASSLTFARNVFVPLTTACRYTCTYCTYYDVPGEASLLTPEEIREQCRVGADAGCTEALFTFGDQPDDRYTAIHEQLGEWGYDSIHEYLRAACEIALEAGLLPHANPGDQTRAQMATVADVNASMGVMLETTADVQAHGGPRAKSPEQRLHTIDVAGDLGVPFTTGILVGIGEDWRDRAESLLAIRALHERHDHVQEVIVQPVRPNARWQGEPPGAETMRRVVAMARAVLPAEVGVQVPPNLTDVRGLVDCGVDDLGGVSPVTKDHINPDYAWPALDELSAIADHAGVPLRERLPVYERFLPADGGTADDGWVSQRIWRAIEDGDRYEAVRAE
The following text describes a protein:
Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Sequence:
MHVDVPHDCFPGCATPLEAFAIALRSQPRGFGWDCSAISALDGRGEVVAGFVLGLPRASPCDKISGPSFVCVSLGSGTRCVGYKPVEFTVEADLMLRDGHAEVMARRGLVAFLLDAAAYLSRGDDRLHFAVERHHCFPQFSGGDASCDAVGECFRLRPGVSVHLVCTEYPCGAMSTPFGGAHVLLSTPSGRSLFDGGLDSNPLLVGEEHVSRCDGKTLPEFVDARVFDGPGSFTVCYGHRVAAHRCWPVDDMPFVARVKPGKGRQNLCMSCSDKLLRWHCLGIQGRRRTRLFPEPIRLAAVWLPRKVSIVSDNCVAVNAFSPLEKAREGLNSRLHCFCPRLRPGELGAPSEGTNEPVRGGSPFPQVDVCDFESSALRLILVGMSGDDTPLGNGGAPKRKDESCWSRAAWATVEDGNQVVPCSAGAKRRRGELEGLVVRCVLRWNEESTAALNTKAGVPRGVTKQSMNRTVQQLLQLQSDVYSGAKPPDPDTAALLEGIASRFPLSRLWMALRQREIARTVSGRYHQSCRRLQAFPPTEGEADHETRRVGNYSLYIPQRVVSVGDMAEIGRNIASGDSVHCWLQGSQRAGESVLDEVWKEGLGRKLPLLWVEKREQRVA
The following text describes a protein:
Function:
Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23. Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane.
Sequence:
MFAKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHMIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERARAADQTTAEQGMRQLEQENAALKESRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEAGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENMLKETLEYKMSWFGSKPAPKGSIRPSISNPRIPWS
The following text describes a protein:
Function:
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress.
Sequence:
MTRGFAPILPVEFHKMGSFRRPRPRFMSSPVLSDLPRFQAARQALQLSSSSAWNSVQTAVINVFKGGGLQSNELYALNENIRRLLKSELGSFITDYFQNQLLAKGLFFVEEKIKLCEGENRIEVLAEVWDHFFTETLPTLQAIFYPVQGQELTIRQISLLGFRDLVLLKVKLGDLLLLAQSKLPSSIVQMLLILQSVHEPTGPSESYLQLEELVKQVVSPFLGISGDRSFSGPTYTLARRHSRVRPKVTVLNYASPITAVSRPLNEMVLTPLTEQEGEAYLEKCGSVRRHTVANAHSDIQLLAMATMMHSGLGEEASSENKCLLLPPSFPPPHRQCSSEPNITDNPDGLEEGARGSQEGSELNCASLS
The following text describes a protein:
Function:
Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIQPLVKASRPRLWVCSDCLLRRTLSPLLRQQRRRFTGFTAHAPKTLTGTIPVTHKNGDTKHDDSLLRSIFDSPETWKQFSGDKHGRNVGLFRNAYLTSPHGFLDFAHVSLGKARALVDKVLNAQSLDEYRAIVRHLDRLSDILCRVLDMADFVRVTHPDQQIQRTASMAWDMMYEYMNQLNTMTGLYDQLVQAMDNPQVSTTWSEEERMVAEVLKLDFAKSAVHLPKDARDKFVHLSSAISQTGTNFIQHMEPKIPYTTVEKSRMMGMDPVEVKRMASMGKVYVQTLSPQASIALRTVRDDHARHQLFMASRTASRRTVHTLEELMLLRGESAKLSGFESYGHLVLHDRMMASTPESVRQFLQALSENTRPQAQQEVADLTAAKRAHKGGDATLEPWDKDFYAESIRQAIKSRQKREDLSSYFSLGTVMQGLSRIFTRLYGIRFVPREPMPGETWHPDVRRLDVVSDVEGHVAVLYCDLFYRPLKSPNPAHFTLRCSRELSPHEIAETAHTQAENPHVLIPSFESAEFAANDGMAYSRSQDGAIKQLPTIALVCDFPQQSHNRPALLSFFQLETLFHEMGHAIHSILARTSFQNVSGTRCATDLAELPSTLMEYFAADPSVLALFARHYETDNPLPYEWVDNKIREARRFEALDTENQIILAMLDQELHSSKAVQGHIDSTEIFHSLQRQFSTAPPDPQGTAWQGFFGHLVGYGSTYYSYLFDRVLAQRVWNVVFNSGQGGAALQRENGERLKENLLKWGGSKDPWKCLAGALKDERLEGGGEKAMKLVGSWGGQRGTKSDQAV
The following text describes a protein:
Function:
Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNSSTDPTFSELNASFTNTPDTLFATSVSSDPSHGFGEEDYACGTFNCSPKEFVAFVLGPQTLPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLHLYAMVGFKRAIRIITALWIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCSMSPKIVNEIPVFEVSFCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVITFFVCWFPFHLQRLIFLYAKNMDNYLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRYRVAFRELLCGKAVGAYYNSGFARDHSSFRESSAYDRVHSVHVRASQHPNKFETDSSSANRVLIKKTYSLPLPKNADSTVLSTTDIVIVLENSHTVCEEPKVENDIWIENEETCI
The following text describes a protein:
Function:
C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A. Triggers degranulation in a SYK-dependent manner and stimulates SYK phosphotyrosinylation without recruiting SYK directly.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MENEDGYMTLSFKNRCKSKQKSKDFSLYPQYYCLLLIFGCIVILIFIMTGIDLKFWHKKMDFSQNVNVSSLSGHNYLCPNDWLLNEGKCYWFSTSFKTWKESQRDCTQLQAHLLVIQNLDELEFIQNSLKPGHFGWIGLYVTFQGNLWMWIDEHFLVPELFSVIGPTDDRSCAVITGNWVYSEDCSSTFKGICQRDAILTHNGTSGV
The following text describes a protein:
Function:
Required for nuclear membrane fusion during karyogamy.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MFEMRYVYLFAICIKFVSSSELGKINNLLQGRLIYTDNSVATNVLESKFPFLKSTCVKDALKLFLPQCIANGLESIDAETRVETAIKLSICEFQASGLGEIPENCMVDDLGSMMDCMFELESSSQWWTTYSGNYQRLSSICYENLLPFEKEQILKLFLNITELYDSFGDDVDTKLNHLMFQMEQDSQNFLDDLARMFRNYDNELRNATESNRIILENDLSFFRNKVNDVLYETSEQLEVQIIEKNSQLMNEVDTVHHIMSDLADELAKNDIKSKINDLKDDSLNNLQDLVEMSNDVKEYYSRNNKLVNTELENFSMGLKKQLGGMSKDLSESQMEAIELLQGFNSILHDSLLPSMTDEIVPEMTNFKNTLLQEWTAITSTLNGDFALWNEEIFSTFNDISEKLNGTKKKLDDIEIRVSLVHKNVMTMMRVLDFMWKTSKMIIRCGYLAVKNKYYWLLCSVVWIWSKYRTSRVNVKMIPIKRYYQWAALLLSIYLGAKTGSLIDF
The following text describes a protein:
Function:
Involved in chlorophyll synthesis and chloroplast protection against oxidative damage.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MGPSSTFLCSQESSVIRGGTKGFLVGKPASWKAQRVPGTAIKRNQCDLSSASNWSRRQDSVIKFKSCSSSIISSSRWRAISRVQQGSIKSHEIQVVYRRGYRRAFCSGCHWLRGDNEDEIFSGRPRMNRASSSRKKLRCLAYDGDSGEPPSVDWTALASIEQAIQFQAREESRLFWFGPPTGDLAEIEAFCRLHRHAESLHTTVMDALRSYSAIASSDVGAGPDRGDVSLVEENVAAGLAHIMSLLHIRKTDLLCSTSVGRPQEEAPLDEPPPFAKFRSEVRECCRPLETALESLLPADSVQRLAVRRSMLKLKNACLDSGFMRPDGLPKHADIPNLAVVRLRPSKNARALHKDEDVAFWRGGQVTEEGLEWLLTKGFKTIVDMREESAQPIAQSAIENAVASGKISVVRLPVERGEHPTKEQVEEFAGLVADAKNKPLYLHTRAGVGRASAMVSCWREHVLREKARERREKKVLTNGTAVNRAETVKENELEKEKAVDLTFEVRAKERDAVESSTGTNMNGQVNAMLGSQVKDVPEVSASNQIVVKDSSSSEVRSVNGKAATTPRDAQVEEMPAFVLKNAFEAQRPPSALSRPALSRFMKQKKNTSMFLSGREKAASKSSYADGRETLDMFGNLAGPAGRWGLASPGIPRAENKAFAEAKEAKEAEEKSALGTSTRDETAVVGGEKQNGYAKADKVYEREDGRDAKNDQEQNDEETEQPSTETKGRNGALFQLHSDQVIPEEGEEPVVVEGDMCASTTGVVRLQSRKKAEMFLVRTDGYSCTRERVKESTLAFTHPSTQQQMLMWKTPPRTCLILKKLGDELLPAFQQVASFLHHQEGMNVVVEPEVHDRLARLPGYGFVQTFYSRDTSELHERVDFVVCLGGDGVILHASNLFRSAVPPVVSFNLGSLGFLTAHPFKEFKEDLRAIIHGHSEMMTGVYITLRMRLRCELYRNGKAIPGKVFDVLNEVVVDRGSNPYLSKIECYERNRLITKVQADGVIVATPTGSTAYSTAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPDSALLELKVPRDARNNAWVCFDGKKRQQLSKGDSVRICMSEHPLPTVNKNDQTDDWFQSLVRCLNWNERLEQRPLNTPS
The following text describes a protein:
Function:
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. May be involved in lateral roots and nodules formation.
Subcellular Localization:
Cell membrane. Endomembrane system; Multi-pass membrane protein.
Sequence:
MGEVADEGQYFRSEIALLNYSDATFKPPLSSLLIHIDPLIIPNGHTCSASESDPSPTSQHHQQEQHPKDAWLPITESRNGNAYYAAFHILNSNIGFQALMLPVAFATLGWAWGTVCLSLAFVWQLYAIFLLVQLHESVPGIRHSRYLFLAMAAFGGTCVMIIITGGGTLKQLLKTLCDNDDHVHEQITCNAHALSGAEWFLVFTCVAILIAQLPNLNSMAMVSLVGAVTSVTYCTLFWVLSVKNGRPNNVSYSSSLQSQEHTPVAKINDVLNAIGIIVLAFRGHNVLPEIQGTLPSNFEQTSKRPMRRGVSISYVLISMCMFPLAIAGFWAYGNQRQITKFSMGAIYVLVIIHCLTSFQIYAMPVFDNLEIRYTSIKNQRCPRLVRTCIRLFFGGLTFFISVTFPFLPRLSALLGSMTLVPITYAYPCFMWLSLKKPRPRGFVWCFNVALGCVGMLLSALLVAAAIRTLALNGLDANFFKP
The following text describes a protein:
Function:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Sequence:
MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNAGLGMNGMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAAGSGKKAAAGAQASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMGPVTNKTGLDASPLAADTSYYQGVYSRPIMNSS
The following text describes a protein:
Function:
Functions in nuclear protein import via a substrate-importin alpha-beta transport complex that passes though the nuclear pore complexes (NPC). Mediates docking of the substrate-importin complex to distinct nucleoporins (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus envelope.
Sequence:
MSEWVPNQDGLKQLVYVLNLSNSTSREVHDQIREELDKFHSVPDYNNYLTLIFKSNELQPHIRSVAGLVLKTNIKQYFEKMPREVQNYIKREILPVLSDPDASVRHTVGNIITNLIKKSCFSEWPELLPALNLALDSNSQDLIEGSLYTLSLLCEDSTKKLDSDDSGRALNQLIPKLIMFFKCNNADFRKKALVSISYFIISMPGALLINMEAFLKGIFSMSEDPSEAVRTNVCKTLVTLVETKIEFLLPYIKDVIQYMLHATKDKSEEVALEACEFWTAISQAEGCRDLLRDYLPVLVPILLNGMVYTEQDYEYLDQGDDSMTPDRPQDIKPFIASTKSHGSGSSGGGQDTGFVNPDNNNNSNNNNSSNNNSSNNNNNNNNEDDEEYNDDDDDDDDDGFEDEAWTIRKSSAFAIDVLSGIFPDAEYLSVTLPLIEQRMNEQNPWPVRESAILALGAIADGSKNGLAPHLSKVIPYLINTLNDPKPLVRSITCWTLSRYSYWIAQADGRDYLHPLVVNLLNRIVDNNKKVQEAACSAFATLEEEADLLLIPYLQMILVTFVNAFGKYQAKNLLILYDAISTLAKVVGNELNKPELINILVPPLLQKFNALDDSNKNLLPLLGCLNQVCSSIGAGLQNLISLFFNRSIKLIEGSLQAHYKYNNQDQKGSSSSSDQDFIVAALDLLQGLSEGIGTSIESLIPNSNLPHLLLQCMNLRGSDVLQSSFALLGDMSKFCLIHFKQYIPDYLNILTNNLYPEYLSVCNNASWAIGEIAIRMPDEVKPFVVAIRDRLISNINKVNLNRGVLENTAVTIGRLGIVSPADISPFVDKFIQCWCMAIRRKTDDIEKDSAFRGMWLIINNNPNGALRHLVYICDAVASWDKMQPDLYEAYFKLLHMYKTSMGGVWAQFYNQFPEQLREILNEKFKLNQDISQ
The following text describes a protein:
Function:
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
Subcellular Localization:
Virion. Host nucleus.
Sequence:
MSNMDIDGINTGTIDKAPEEITSGTSGTTRPIIRPATLAPPSNKRTRNPSPERATTISEADVGRKTQKKQTPTEIKKSVYNMVVKLGEFYNQMMVKAGLNDDMERNLIQNAHAVERILLAATDDKKTEFQKKKNARDVKEGKEEIDHNKTGGTFYKMVRDDKTIYFSPIRVTFLKEEVKTMYKTTMGSDGFSGLNHIMIGHSQMNDVCFQRSKALKRVGLDPSLISTFAGSTLPRRSGATGVAIKGGGTLVAEAIRFIGRAMADRGLLRDIKAKTAYEKILLNLKNKCSAPQQKALVDQVIGSRNPGIADIEDLTLLARSMVVVRPSVASKVVLPISIYAKIPQLGFNVEEYSMVGYEAMALYNMATPVSILRVGDDAKDKSQLFFMSCFGAAYEDLRVLSALTGTEFKPRSALKCKGFHVPAKEQVEGMGAALMSIKLQFWAPMTRSGGNEVGGDGGSGQISCSPVFAVERPIALSKQAVRRMLSMNIEGRDADVKGNLLKMMNDSMAKKTNGNAFIGKKMFQISDKNKTNPVEIPIKQTIPNFFFGRDTAEDYDDLDY
The following text describes a protein:
Function:
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Sequence:
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLSEKLGKLTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPEEHLVRVKSRDGRTLSEEDIIHAMEDDIALILLPSVLYRSGQILDMKRLTTEAHKRGIHIGFDLCHSIGSIPHHFKDWDVDFAVWCNYKYLNAGPGSVAGLYVNSKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKDAGIERLREKSLHITRYMLNLIGHELKDFEFTIGNPLEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWKSVQILKKIMKNEEYKQFENKREVVA
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MMAEVGITDLFTQLCKSHYKVDARQPRIVRPKLSKQQISSRLRNTLFNTLFEDTLARRNGLAEKGGVEKQEKLSEKDKMLVFVYELRLERRFDDAARLEHLVDMLYSEADPDADIKAVLRLFLGLARSGSQPDIPPIGYHDPQLPMKNLKRHEMNGWLCPCGPVFYGDSKYLEDSFHGYMQYDRSLFEHGLPASMITMYSTGQPQPGLSWKLFEATPGQDLLGNGLFQLKGMKNDQYERQTNSTLYGALVHSHTRSIDIKLGLPELPDETDTQALGLKIYPYTELSEDEGFTEPSDTESSLTTPSPDLLVEEDIWEQALTYKPSQHRTWETIGCVPGPTEKPYLTEAGREVFDAMYTMVQRQVQESGLDSSTVQKPVSYMVQERDLVRDARNVLIGVPSHTFILDQVTQSFSVREGIHISGTTPGAMRQTLRRFAEIGTNYRRLATFAAPPIMDSFYQGGLIFQAFTGGLRKYLQYYRYYVLSGSTSVSLLNLEMLYRKLGTQIKYLAELCMCSSSSQFNPAGRKGVPEGFPTGVKLLTYLYKESLDACNTDNYPALLSLLQHSTGPYITFVQDWVFDGICRDIYGEYTIEVNDEFLCFRDKHYWTQGFTVATATVEESVPLFLADLANNIFVCGKSLNLLRLCCPGHHLCTRDVPVPRLALTFSMEDLSNIEQRCAEYVGKMEGIARHKTVSREEMEKRAVQARQDLVVLARQTASKEIDRIQSERQKALEEADAKKRQQFQELKEQMEQDLQRRASEKEKEAEEDVAFIEGLKRRESEEAEAEAELERQAREQVVEYYAKLGEEASKREQRALWKIRRHRLDQARLNFLLKEEKNLKKGAGPNSGEEQGGRSGSPNVADQTGMLVSFAESPEQSVETGKLVSFIAEPSAKPPMVLHSILEGRNLLDLSIEEFLPKSQSTVEEAQEDASGAKLDEVLLEIGSDLPHEERKSSDTSVPAQTIADLQHGYSSLSSVFSEEEITSPAGGDGIKKSHPSDSVFTSDGGMGDGAEEKAGIQVGKRGHHSDSVFTAGGEMKEGESHKALIRVGKHGHHSESVLTTWGEVKEDTQKRVVRRGEHGHHSDSAFSPRGEIREEDVKKPLIRVGQHGHASDSVLGDLISGEQDQDSTRQVARSQHGHPSDLSEVPDNARPQRSKHGHASDMSLEPDSAKPRRSKHGHASDLSLQPDAAKPRSSQHGHASQSTAQDILYPATQLEPDGIAKPQSQIPVLPTNAQHGVPKSSRGKIPHGHSSDSTVEGILYKEAIDSTWVVKRSRFKERNVHGHHSDSSVQRLLYPQEKKDSDAQKALVVSKARGTVSANIAKKVWADQQVEPLPDNFDMLDNPPSVDLLGNLGVIPYAMFGDYGSTTSDEVDSVDIVSLPVLIKRSITSPLTAQITLVNKAIVDYFIVELKAQRHFKALRTYLLMEDGEFGHAISDQLFDKLAQGLSPQELLSPLVLNSVLTRAIQTSINRDSDYTANFSFALKWLPEHFKLNAHDTLDCLELRYKVDWPLNIVITDTTINKYNKIFSFMLQLKRISWVLKDIWFHLKRCAITNRAGNSSQYRQLQLFRHEMQHFVGVMQGYVSNQIIHVSWQEFCKELRENVHSLDELHQRHAEYLNKAIFRSLLSRKAGPVMKVITDIFTVILKFRIQLVSHSWQFDETRNEAIHLAYPNMASSFHAFQKYSEFLYRVVKKLVARGYQPHLEDFLLRLSFNNYYQDV
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MSTKKHLVSLIHVYAAASIKESNAAAGEGKNIREFHILCSLVELCKKTPINLPGSSLLDDDVRAIELVNMSGSTDEWQSQFPTTDKVSGEKSIDCEKQPKQISCHEKYDKWRATRKALEAEPNKEIKQTPAKGIQNTAYGRRIHIQINDIAKEAQVIYNNYKAETAPVLNGINDKLRIHFGDALYGKQDRPLAGAPADKWQASGTRNNDCKGAKAGISPRGDLFCLCAQDTTIAEHMCGDTVTAAGSNWLLATVAPLIDGMASKCAGKAKPTITASYIRHALETFDSALKSHTQGTKDAVVLGTPHSSGVCGGQASVACVDYTAAVMPKEQGKHNDIKWYNELTDASKALDNYAAAMAEEKAAQTKIQKLKQEANRLFQTLKVQEPAAIPPISQLPRIDPLELKKKCEQFHNKSKECTENGCKWKGTDETTGTCDVDETKVTSQTNAAGTGEASNEETATSGCAKHKDKTECDADKKDDKQNCAFRKGKDVEDDKDTEKCRSSGFLVNNKLVQSIAAVFVSLVPS
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MCHACLELSVRGKVRALKTHKLLLPGDNIAVALSGGSCSLTLLSNVLPMRKDASTPRKERGKIEFGLTVIHVNEATAHGAAAAEAEAHSRDVVAAARQCAAVAAAMTTAESGGSSTAASTSTSMGNASPGLDVWVVPLRDVFLLGDAEALRREAVRSWRQQQQQQQQPAADGTPVWGGEAGGDSDYVGEAAATASGAAEREARLQQLLQAVQDPTGREDLIRHLRRRLLAAAGAVAGATKLLCGDSATALAARVIAETAKGRGFALPSDIQLVDARGTGAGEPTFLYPMREVTVKEAVFVCRLRGLHLAELPAPLLLARLSSASTGLHSHPPRRSINSLASAFVDSLQANLPSTIFTVLRTASALRPFPFNSPDAMPSTFPATPNNELKALHGRSTEGASGANGDGVAVGCRPAAVPCCVLCRAPLSARELRAIHAAAASAADAGKQEGAGSVEVVQAEQEEGDDEEDAAAPFCGSCRGQILFRPGHHEARGREEAGGSGNVDGPSLVQGLLPEALAA
The following text describes a protein:
Function:
The terminase small subunit binds to the packaging initiation site and regulates the ATPase activity of the terminase large subunit. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging 'pac' sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities (Probable). Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging). Once the capsid is packaged with the DNA, the terminase complex is substituted by neck proteins.
Domain:
The N-terminus contains a helix-turn-helix (HTH) doamin that is involved in viral DNA binding.
Sequence:
MEGLDINKLLDISDLPGIDGEEIKVYEPLQLVEVKSNPQNRTPDLEDDYGVVRRNMHFQQQMLMDAAKIFLETAKNADSPRHMEVFATLMGQMTTTNREILKLHKDMKDITSEQVGTKGAVPTGQMNIQNATVFMGSPTELMDEIGDAYEAQEAREKVINGTTD