lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Nutrient transporter. Substrate transport is pH-dependent. Can transport arginine, lysine, histidine, peptides, histamine and spermidine. Involved in maintaining the osmotic homeostasis of the digestive vacuole. Required for the normal asexual intraerythrocytic proliferation of parasites (By similarity). Can transport Fe(2+) and Fe(3+) (By similarity).
Miscellaneous:
MISCELLANEOUS: Can function as a drug transporter. Can transport chloroquine, quinidine and verapamil. Drug-resistance-conferring mutations reduce capacities for the transport of the natural substrates. Active transport requires a directed pH gradient and a membrane potential.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Localizes to the parasite digestive vacuole, the site of chloroquine action.
Sequence:
MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIFIYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSKERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYHLYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKIDILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVENCGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAYYFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDSIITQ
The following text describes a protein:
Function:
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Sequence:
MFPISVGWIAFAGVLLTLIALNYFIVKYYSDKHESGKITTIISVIGLTLTLLCVMLIPVDILNVSTMSHSDGTQISPYSISQRTEGVKMLYYILYGSILGVSLILVPFAYFYHEEYDENIPTCSRVYAGCKFTIFFILFTIILLVVGAFVRPGSKPIDDQNVKDWINDEVLNQNAIESSVLFAISCLTVLGFLVFAVYTSYGLSAFPIGLIKGKKRTDDDKSDINKDLWKAKEKSSFYSSKYASGKSLSEKEQSTLSLLRGKERALSKRSERLDNSNKGFRKILVIFRPFAFIFGFIFILVSLLIIISIVLSLVDKISSSVCGSACGFLSTYPQLKNPFDIILTKLAPYFPLDYIIIGGLIFFIYSCTLSGITRIGIRFLWINMFEFGYRKTFPQGLLLASVLLMLSNLCLNMQIVNLAPRYVMYGAQVYLNGTSVIPCTINAPTDLCIMSEIGLLTSRIQLGISFFGIVFYYGTWVIVATFILGLAVSIFKRRPSAALSYSGDSDEEEI
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MHTTTAAALILTLTAAMQRHASATAGDVVKGASWTPLCSITADSEKLAANLLQNLIQNARDGETALQRLLRALVYNEATGGQPLSNATMAVWSLYAEVAGRAAARIQQTEAKAVVTAARNIGRLQGAISEFLESQADASADNKGCLQAAAGTTAVIVGKQQLYREQPTCKMSWDEVKNEKTTTSVITATGIKHTNSGGQENGQTIHSGQGTDCDISQPQSSFKLTYGSRGNDVAGHVPKLAAGYFTVDATGFKIPKHDTLQDATTASPYLGKAIEAVTAVPAKEAATSIKTIAELKAHQDFKGPARRYLLGKKLTETDGDTQLEEKITNAYVNDDNAKKALFEAVDAYQIHDNLRPSPADDTLGKITSIHILMHLYFHYRSAREQAIQNRMQKLQEKAKHASDTISTEEKEKECNTKGKDDEEACKKLAKDGCVFNPKGNEGKKCELKKEVKAEPEKEKENEEKDKKTDSKCTGKEQKDCEKAPECKLENNACKNSIFLVNKKPVLMADAFADL
The following text describes a protein:
Function:
Transcription repressor involved in the circadian clock. Binds to the promoter region of target genes to repress their transcription (e.g. PRR5 and GI). Regulates the timing of floral scent, by restricting the expression of ODO1 and other floral volatile benzenoids and phenylpropanoids (FVBP) pathway genes (e.g. EPSPS and IGS1) to the evening. This scent, mostly produced in the evening and night by the petals, attracts the pollinators (e.g. the night-active hawkmoth pollinator Manduca sexta). Binds to and repress ODO1 and FVBP genes (e.g. EPSPS and IGS1) promoters via cis-regulatory evening elements.
Subcellular Localization:
Nucleus.
Sequence:
MDPYSSGEELVVKTRKPYTITKQRERWTEEEHNRFLEALKLYGRAWQRIEEHIGTKTAVQIRSHAQKFFTKLEKEALIKGVPISEALDIEIPPPRPKRKPSNPYPRKTSIAVPTSQVGTKDGKLSTPFPSICENRNLLDLEKEPIIESVGGNEKLSNVQENQNKKNFSQGFTLFKEGASAASVSLGKSSQTLAEPTDSCTLNESVSVSKGVINHDVANKSFPAVESKGHQQLDILDAKQSFQFDSSCNTSSVGKSCQSNEKWAQGEQKDQPSQPDHFEEFSRNDMQVPHNYPRHVPVHILDGTLGANGAQTTPDMFYHKSVSHQVGGLQGLSDMYTNPASSATSEQHSNAARSSIHQSFPCFHPIFTPIRDPDDYRSFLQLSSTFSSLVVSALLQNPAAHAAASFAASFWPYANMEAPVDSTGNNTASQINSAPSMAAIAAATVAAATAWWAAHGLLPLCSPFHSSLTCVPTSATSMQVDVCQPKEGKSEGREGTHNSPPHVQQPGPECSEALQEQHSASKLPTSPSSDSGESEGRNLKNGLTATDTEQGAAVTETHEPNAEKVRKQVDRSSCGSNTPSSSEVETDALEKDEKGKEEPEEPNVNLLAGDAANRRGRNCISNSNDSWKEVSEEGRMAFQALFSREVLPQSFSRSNYLKTKGNIDFEKFQQKPDEQGPSGSQLDLNDQASNICSSHQAVEENVQFLLGNKEGAEKCQPTMELGEIRLKARRTGFKPYKRCSLEAKDSRVANSSCQDEEKSCKRLRLEGEAST
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Sequence:
MLHKLSILGALVAIFLLSCSAVPIDDKQQEIQPQPQAVPAEKRLDTPEAQPTDKNESDLGPPAEEKSDLDTANTFWGWGGGYYRRPYYGGYGGYGGGWRRGYGWGGYGRGFGGWGGYGGGWGWGGSRYYWEKGTSGAVIMDVKSDIQDFFRDQTIFITGGTGFVGKVVIEKLLRACYDLKMIYVLVRAKKTQSSGERFQKLFDMACFERVKELRPNFREKIQMIQGDCSEPLLGLSSQVREILKKEVTVIISAAADVRFDQDLRQGVNNNVRNVKETLDLAKEVLNLKAMIYVSTAFSNPDHARISEKFYKPLISAENLLHLVEALDNKMLKVLEQSILKKWPNVYTFTKSVAEDLIKREGKGLPLAIIRPAIVISSIEEPVAGWVDNLYGINGQTTGILLGAIRSIYYIKKYPAHLVPCDFLANFLLATTWNLSNQNRSLENPIQIYSCVPDDCIINSDVAVYVEKSKWLYPMGNMFYFPSCSYTQCYYYHKLRLFIFHLLLPLIVDGVLICLNRKPVATKFYGKINKFLELTHYFRTTLFQFENTNLKHLWQQMSEKDKEMFNFDFSGIDWEPYMVESVKWSQHFVFKQTLGDLPKRKRRLMIFAFAHYAVTALIAFLAIHLLYTLFL
The following text describes a protein:
Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Sequence:
MGRRAMRQSCGAQIYRADLWGSTDLWGLRIYGVDVWGSRDLWGADLWGAPHVSASQTKELLATFPARMAELGLMLTAPIFSMGSEELRAPLDIPMPDPNQKKKKGKDEEEEAPPCPPIPSHGSILALLEKLRPLLAEGRIHLAQVELWLKLQVPRIEDGDNFGVAVQEKVLELLTSSHTQLETLQNRIPKYLLERGDAVAKAVKNPHVEDYRAAVHVLDVAELSAARLALTQLRDAYAVLLDAVRKNLDKLQKPRGEPKSIIF
The following text describes a protein:
Function:
Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates. Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain to lysosomes for degradation (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MADFQEQLRQYRAQKRRKETVDNFKDKLRRFWMLGTGANKDTTIEVQQVPTKFEAISENSQDEAVTSSESELVPEEQPTRSTDHHHKENNCLKYTLWTVYLLFWITLYVIAIKLSFGLVFLMFSALFGIYFNTRTEPKKRNEMSAYSVFNKNCESIDGTLKAEQFEREIRYGSGSVR
The following text describes a protein:
Function:
Involved in adherence of spores to the host cell surface and in infection efficiency.
Subcellular Localization:
Cytoplasm. Spore wall. Spore polar tube. Note=Localized to the cytoplasm of sporonts, to the cytoplasm and surface coat of sporoblasts and to the spore wall and polar tube of mature spores.
Sequence:
MSTQPTKTSSTKLRIFKWLFIISTLVAIAIPITRLLMHLYGKIDEKMYARIFMSYRVNSADSFMINGRYKAIKAKAYPTSEERNKFNSIAQEGDKAVLLKYPYPEHFSLEPEWHYTLCDDVFYNLWKIRVNVCEYYKNNKQEDIAGLVTPPKEAKVDRFFRQDPKISDDDYKKLFTGTDENGKGWSSAAVQFIDILLNLINKPEECKLKDGKLNEKFQKDLESLVSQLGYSTEDMKNIANEIPNFFIQFGKAFPTVIHSTVYSRFYYFFLFLTINGNFDFSEVEKTDGMKIEEFNKQTMKVMASVFAQIFAKVYEESYNYEIKDAGFMDKVRAYFSVSDNIDNVKDQTKNINTVKEVLIKNKELLSK
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MKITVNFLLVALIGVPSVLSDRHITRDKRQAMRDYAKWENNKMSLFFYNLPLEMQAMFRDAINYLENHTCLKFEYNENAETAVRIRKGNGCYSLYGMHAGEVQDLTLDYNCASFGTAVHEIMHALGIAHGQARSDRDDYLIVDSTNSNDGIENTENLVPFDYGSVMLYARDPHSDKRIPIDPEYNFTMGSLRVAFYDMVLLNKFYGCNCDNHPRKLDCKNGGYQNPANCEECLCTDGFNGQLCDQHEGVYVLEAKKEWDASGVRNNYRKGIETNTMPEYTYFALTAPEGSTIEVRITKLSGFFCQHTCDYNGVELKYKTDRRIVSPLVCCDNDNLWNKTRSSTNNPFIIAKYGNNRTPHFEFEYRYIPGNATAAPEENN
The following text describes a protein:
Function:
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKSILNDFLLMIQFFTRIPVNKNLQCEKVNFRRGAFFLPVVASIIGGIEFLVYLGLKNFLPPNVIIVLLLLFTAMITGGLHMDGLADTCDGFFSLRDKERIIEIMKDSRMGAFGTIAMIINLLLKYQLLYSLVLKDCSIAIILAPVIGRISILFLCLSKRTAKKNGSGNIFIGNMSKPIIFLITIIALAMNTYFLGLKITIISFIAVLIITYLFYLLCLNKINGLTGDTLGACNELGEITFLLILLMM
The following text describes a protein:
Function:
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular Localization:
Nucleus.
Sequence:
MNMENTEFVHESSPNHPQQFSPEKLKTENFLIDDLLNFPADEMVPAVAENIVSGASTDSSTIVDTCNSPLCGGAEHNSPGDVPRRSFTDAPFTSDLCVPYDDLAELEWLSNVVEESFSCEDLQKLQLISGIKTRPNYTSNNQQFQPETVSKANNPIFNTDMAVPGKARTKRSRAAPCNWTSRLLAVSPTASGTTVTMSSESESDIASSSIRKKIVKAGIKRKEVYDNPSHNGDGRKCLHCATDKTPQWRTGPLGPKTLCNACGVRFKSGRLVPEYRPAASPTFVTAKHSNSHRKVMELRRQNEMHQHQYMHQNQRQHQHQSQHQHHHHHHQQQQQQQLFHHSNMIFDVPNNDDYLIHQHVGPDYRQLI
The following text describes a protein:
Function:
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MATPFIAGLSVAAAAMAGKYSIEAWQAFKARPATARMRKFYEGGFQPVMTRREAALILGVRESAAQDKVKEAHRRVMQANHPDAGGSDFIASKINEAKDHLLGQKRGSGSAF
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Active on long chain acyl-CoAs.
Subcellular Localization:
Mitochondrion.
Sequence:
MKRAAMRLWTLNKGLLTHGRGLSQGSQYKISEPLHIHQVQVKLREIVGISTVWRDHVQAMEERKLLHSFLPKSQKVLPPRKIRDSYIEVLLPLGTDPELRDKYVTVQNTVRFGRILEDLDSLGVLVCYMHNHNHSTNMSLLSIVTVLVDKIDMCKHSLSPEQDIKFTGHVSWVGNTTMEVKMKMFQLHDDETYWPVLDATFVMVAQDSENKRPAFVNPLIPENKEEEELFTQGELNKSRRIAFSTSSLLKVAPSSEERNIIHELFLSTLDPKTISFQSRILPPKAVWMEDTKLKSLDICHPQERNVFNRIFGGFLMRKAYELAWATACSFGGSRPYVVTVDDIMFQKPVEVGSLLFLSSQVCFTQGNYIQVRVHSEVFSLDSREHMTTNVFHFTFMSEKEVPLIFPKTYGESMLYLDGQRHFKSMSTPVTLKKDYPVEP
The following text describes a protein:
Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Sequence:
MEKTLHNWSRGTVTQAAWGGTEHPPSWCWRGALQRLDDRLAGIWSRVKDGTRQGFCICNYVILQGVREEEKGRGRQREKGELMGLGRHQTKQPLTLLALLWLFRKQELANSPDVTIPDRPLSPPLTAPPTMKVSDLGIKLEEQKPGPQKNKIVEKGGPYPLVILPQFGGYWIEDPENIGTPTSSDSSIFEEEEENLSPGMFGYRLECKGEARAYRKHFLGKDHLNFYCTASSLGNLILSIKCEELRSLWLTVPSFSLRSKVKTVHERIPLAGLSKLPSIPQIAKAFCDDAVGLKFNPILYPKVRISKITLEEELFGNNEESPAFKEFLSLLGDTITLQDFKGFRGGLDVTHGQTGLESVYTVFRDREIMFHVSTKLPFTEGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQAENPAGETPSYKVSVTAREDVPLFGPPLPSPPVFQKSPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDDLHIHTQAMLGLGPEEDKFENGGHGGFLESFKVKEHSRNLTQELPGTLSEDVWHVRFSLWYFSWQPPVAAATAKNQSRSPIKRRSGLFPRLHTGSEGQADSRTRCTPKTPDGGHSSQEVKSETSSNPSSPEICPNKEKPFVKLKENGRSSISRSSSSTSSFSSTAGESEAMEEYDIGSSQPSTASPFKQEVFVYSPSPSSESPSLVAAATPVIMSRSPTDLKNRNSPRSNLKFRFDKLSHASSSHEKRIGLRSDLNPILAL
The following text describes a protein:
Function:
Able to cleave dimethylsulfoniopropionate (DMSP), releasing dimethyl sulfide (DMS) and acrylate. DMS is the principal form by which sulfur is transported from oceans to the atmosphere.
Sequence:
MTAMLDSFATDLTAATSLHQPGNLPHPPHAIDAENVPLSGGTDPTYGEVRWRTLINGTEAAPRDMVLGIAEFGPGHQLRPHRHTPPEFYLGLEGSGIVTIDGVPHEIRAGVALYIPGDAEHGTVAGPEGLRFAYGFASASFEAIEYRFTASA
The following text describes a protein:
Function:
Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQRQNTQAAGMPMMPQVPMVGNGVPYVVPIQPVFAPLPPDYRSLYKKLYGQGAFLVDNPVEASSPYDFSQPILKFGKLPIKQVLRDNESQQKDRKNLPRNQKSNEIQEKQTFQTPSSEKSTTERESRPFVPPNSQQMRRMLFIGNIPKELDDFWMDKILRLSGKLASWRRVADADNSMTSFGFAEFESNEQFSRALEALNDFVVPPLYEGGPSTRLSLITDVENEGLYREWQTSRYARNKQKEINILQQIRFNLERICQDIGNFDVRSRIERAARQAREKNEKLLQNVKTSEIPINAADLEGINPELLPVIEEEIRSFRDQSAMKKREKQRSKDEYASLYKEYTRKEQEKLRKQNDDLQNLLSKHRISRIPMSTVNAFLRAEDSIPESFSDEQAYYEEKRRKDQLEAEEYYARERRWMNREKARTAALEREAAREEEERVNNTSFGTYLSEKLASFDDDEEARVSRDEYFVDRAAWIRHRAVARAREEDADALDRKEEERELRTRGEGATVETENYVENGKLVTSEMPQHENGPFKIKIQTKKPAVPSERREFGLPERLLLEEEDEEPQGYSPNPQKPKPAMEENDAEKTKRLRSLIEKIPVEAESLWALPIDWSKVTEDLLKEEMQAFVTKKIIEYIGIQEDSLITFTIDHIRQHKGAEQLVSELDLALAEDAPEFVSKVYRYLHVLLILRSEA
The following text describes a protein:
Function:
Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development.
Subcellular Localization:
Nucleus.
Sequence:
MPATPVRASSTRISRRTSSRSVADDQPSTSSAVAPPPSPIAIETDEDAVVEEEKKKKKTSDDLEIITPRTPVDRRIPYICSILLTENRSIRDKLVLSSGPVRQEDHEEQIARAQRIQPVVDQIQRVEQIILNGSVEDILKDPRFAVMADLTKEPPPTPAPPPPIQKTMQPIEVKIEDSEGSNTAQPSVLPSCGGGETNVERAAKREAHVLARIAELRKNGLWSNSRLPKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREIKEKRKMCAGIAKMVRDFWSSTDKVVDIRAKEVLESRLRKARNKHLMFVIGQVDEMSNIVQEGLVSSSKSPSIASDRDDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATVDMDDFLYTLPPEYLKAYGLTQEDLEEMKREKLEEQKARKEACGDNEEKMEIDESPSSDAQKPSTSSSDLTAEQLQDPTAEDGNGDGHGVLENVDYVKLNSQDSDERQQELANIAEEALKFQPKGYTLETTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLYDDFMSRRSTKENLKSGNMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFVVEKLQLDVPARLFEISQQDPSSSSASQIPEIFNLSKIGYQSSVRSAKPLIEELEAMSTYPEPRAPEVGGFRFNRTAFVAKNPHTEESEDEGVMRSRVLPKPINGTAQPLQNGNSIPQNAPNRPQTSCIRSKTVVNTVPLTISTDRSGFHFNMANVGRGVVRLDDSARMSPPLKRQKLTGTATNWSDYVPRHVVEKMEESRKNQLEIVRRRFEMIRAPIIPLEMVALVREEIIAEFPRLAVEEDEVVQERLLEYCELLVQRFGMYVEPVLTDAWQCRPSSSGLPSYIRNNLSNIELNSRSLLLNTSTNFDTRMSISRALQFPELRLIEYDCGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPKVFCFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQKRRLGELAIDEAGFTPEFFKQSDSIRDLFDGENVEVTAVADVATTMSEKEMEVAMAKCEDEADVNAAKIAVAEANVDNAEFDEKSLPPMSNLQGDEEADEKYMELIQQLKPIERYAINFLETQYKPEFEEECKEAEALIDQKREEWDKNLNDTAVIDLDDSDSLLLNDPSTSADFYQSSSLLDEIKFYDELDDIMPIWLPPSPPDSDADFDLRMEDDCLDLMYEIEQMNEARLPQVCHEMRRPLAEKQQKQNTLNAFNDILSAKEKESVYDAVNKCLQMPQSEAITAESAASPAYTEHSSFSMDDTSQDAKIEPSLTENQQPTTTATTTTTVPQQQQQQQQQKSSKKKRNDNRTAQNRTAENGVKRATTPPPSWREEPDYDGAEWNIVEDYALLQAVQVEFANAHLVEKSANEGMVLNWEFVSNAVNKQTRFFRSARQCSIRYQMFVRPKELGQLVASDPISKKTMKVDLSHTELSHLRKGRMTTESQYAHDYGILTDKKHVNRFKSVRVAATRRPVQFWRGPKALESRNLQSLNGGMPPRHESRLAEFDVKTNIRLDAEDIVTMSDESIVAYEASKKKLLASRQTKPSPRQDVRFHTLVLRPYTVPVTTEYSAAPSRREMRIAVPPLQPSALSTISSVAAAATSGPLPSIQHLQSSSTGLGSQQNLQNSHNSEQRNNVQNMHQNQYNSSQNPPIPIRQIGAASSHQHDQGSQGPGGKPQAYHLVQQGSQQQQQQQQQATLQRRNAAAAAGSNVQFIQQQQQQQQSGKNCGQGQSFVVMGSQSSSNDGQGGASTVGGGGGGSQQPHQQQQQQPQQRIQYIPQVTGSGNNGGGGGRGGYGSTLVMPRGGRVVRPAGTLPGGGRLYVDHNRHPYPMSSNVVPVRVLPATQQGQQRMMTGQRRPAPAPGTVAAMVLPNRGAGGIPQMRSLQRGSYTGGGGQQRINVMVQPQQMRSNNGGGVGGQGGLQGGPGGPQGIRRPLVGRPLQRGVDNQAPTVAQVVVAPPQGMQQASQGPPVLHMQRAVSMQMPTSHHHQGQQQAPPQSSQQASQQAPTSDSGTSAPPRQAPPPQN
The following text describes a protein:
Function:
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor; Cytoplasmic side. Cell junction, focal adhesion. Note=Colocalizes with SDC4 in ventral plasma membrane adhesion plaques.
Sequence:
MGVMAAVGALPAGAGSLPPLPTLGVPGVPELKPLTRYEAMRLGPGWSHSCHAMLYAPNPGMLFGRIPLRYAVLMQMRFDGLLGFPGGFVDRRYWSLEDGLNRVLGLGLGCVRLTEADYLCSHLTDGPHRVVAHLYARQLTLEELHTIEISAVHSRDHGLEVMGMVRVPLYTQKDRMGGLPNFLANSFVGTAKFQLLFALKILNMVPEEKLAEAVAATQKPKKPAIDHAAVAAAKQANELAAAARAGNEYADSGENQAAAHAAAELAEQQAAGLESQAVLEHLAAVPGAEAVVAELHAQPGADAVLEQPVAEAME
The following text describes a protein:
Function:
Immunogenic protein. May be part of an ABC-type nucleoside uptake system involved in the purine salvage pathway.
Subcellular Localization:
Cell inner membrane; Lipid-anchor.
Sequence:
MNKILLLILLESIVFLSCSGKGSLGSEIPKVSLIIDGTFDDKSFNESALNGVKKVKEEFKIELVLKESSSNSYLSDLEGLKDAGSDLIWLIGYRFSDVAKVAALQNPDMKYAIIDPIYSNDPIPANLVGMTFRAQEGAFLTGYIAAKLSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISTQYIGSFADLEAGRSVATRMYSDEIDIIHHAAGLGGIGAIEVAKELGSGHYIIGVDEDQAYLAPDNVITSTTKDVGRALNIFTSNHLKTNTFEGGKLINYGLKEGVVGFVRNPKMISFELEKEIDNLSSKIINKEIIVPSNKESYEKFLKEFI
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MIRPRFSCNKGAVWRLNIQRRPVSQLLRPSRFGEFCNCTVYSIQTRFNSTNSRSSYTAPSHTSNSASSGRKKGSFGWKKIISLTIILGATGYSVGVWYAFKDRHFYDFFSNYFPYGKRLLSAIEDSDFGRKYLNAGLVLVRTVPLPPSAKAKEEESISVQIANTLADMGKTEEKGESRHFKLTHLVPPGDSFVQPAIDIGSDLETGVSVTRMPPVVETLNKAQVAEFNDTKEELGKTSSRIQALEEELQLLKASQEELLEVKKEECEASYKQRLEQAEHEYDELWTKSFDKERERLQNLYKSRLQLELTKSMNIFEEKLQNELREQALELERLNAMKVTMMVETERQGRLGKLQQVQEGLEKVQQLAFASVARAQQLDQAAKLATAIDLLSNDSVHSKHEALKYISGLHWNDPLVQKSVAILQNTFSRGGIPSLAEIHSRFDVLSDELSRTVHVQPNTGLLSHLFHTLLFRLPVIENQVSKNSSVTGVLLRARSALHANNLEAAVYELSQLDPWHRALTKDWVSTCRQRLELQQSLEILMAVSALRACTTSAA
The following text describes a protein:
Function:
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Sequence:
MAQIRIHEVNTRIENEVEVSKFLQEEGVLYEKWNISKLPTHLNENYSLTDENKAEILAIFSKEIADVSARRGYKAHDVISLSSSTPNLDELLINFQKEHHHTDDEVRFIVSGHGIFAIEGKDGKFFDVELEPGDLISVPENARHYFTLQDDRQVVAIRIFVTTEGWVPIY
The following text describes a protein:
Function:
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MVTFMVFGASGNLANKKTFPALFHLFKRNLVDRSSFYVLGYARSKIPIGEFRESIRESVKPDTESKQVFQDFIDRVSYFSGQYDQSSSYVEFRKHLESVEKKADSSKALRIFYIALPPSVYVTVSSHIYENLYLPGKSRLVIEKPFGKNYQSAVKLKEEVHKHWKEEEIYRIDHYTAKDMVNNFFTLRFANSSSIDAVLNRHSIQSVEIHMYETGGCEGRIGYYDANGVVRDVVQNHLTQIFCIAAMNEPKSASASDVRAEKVNLLKATRPASLKESMLGQYTTSEDGKIPGYLDLEGVPKDSKATTFAASTLHVDNDRWKGVPFVFVSGKRMKKGEVYIKYYFRLKDSGIFSDVKRRRYLILHVQPEEFVNLTCTINKPMTTDLQPIDAYASLNYNEQFKDLMKEKRDGYEILFEDAIRGDPTKFIRYDEVEYAWKIWDEILDSPKKPIPYPAGSDGPEGLEAYMKRHLGHE
The following text describes a protein:
Function:
Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin (GA). Acts upstream of GIS, GIS2, ZFP8 and the trichome initiation regulators GL1 and GL3. Binds the promoter region of ZFP8, which may be a direct target of ZPF5. Is not involved in the regulation of trichome branching. Modulates root hair initiation and elongation in response to cytokinin and ethylene signals by directly promoting expression of the CAPRICE (CPC) gene.
Miscellaneous:
MISCELLANEOUS: Plants over-expressing ZFP5 show formation of ectopic trichomes on carpels and other inflorescence organs.
Subcellular Localization:
Nucleus.
Sequence:
MSINPTMSRTGESSSGSSSDKTIKLFGFELISGSRTPEITTAESVSSSTNTTSLTVMKRHECQYCGKEFANSQALGGHQNAHKKERLKKKRLQLQARRASIGYYLTNHQQPITTSFQRQYKTPSYCAFSSMHVNNDQMGVYNEDWSSRSSQINFGNNDTCQDLNEQSGEMGKLYGVRPNMIQFQRDLSSRSDQMRSINSLDLHLGFAGDAA
The following text describes a protein:
Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (By similarity). Stimulates IPL1 kinase activity and facilitates its association with the mitotic spindle. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles.
Miscellaneous:
MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Sequence:
MDWAIKAARKKTQRKPGSTRSIIETLDDLNNLTTDAHSEINQRLYESSEWLRNNVYMNTLKYEDKKMEESLISPENTHNKMDVEFPKMKGEYELSNSQNDAAKDVTKTPRNGLHNDKSITPKSLRRKEVTEGMNRFSIHDTNKSPVEPLNSVKVDANESEKSSPWSPYKVEKVLRESSKTSESPINTKRFDNQTWAAKEEMENEPILQALKKAESVKVKPPPNSGIARSQRRSNMFVPLPNKDPLIIQHIPPTKSSGSIPKVRTVKESPIAFKKKSTINSPAIRAVENSDTAGSTKASSVFDRLSSIPTKSFENKISRGNVGHKYSSSSIDLTGSPMKKVSQKFKSINSTDTDMQEALRDIFSVKNKITKNNSPKGKNSRKSSIPRFDKTSLKLTTHKKLAIIAEQKKKSKHSSDVHKTGSRPHSISPTKISVDSSSPSKEVKNYYQSPVRGYLRPTKASISPNKNKNLTTSQTPHRLKIKEKTLRKLSPNIADISKPESRKSKNYRLTNLQLLPPAEAERDDLKKKFDKRLSGIMRSQQEHHRRKQEKQKRMSHLEQDLKKQTSFSNDYKDIRLKESLAPFDNHVRDTINKNTAFSTDNILATINTVDHREIIGNVTPKIASVNDSLPEINTDSEDEASVTLAAWAKSPYLQEQLIRQQDINPQTIFGPIPPLHTDEIFPNPRLNRLKPRQIVPKRS
The following text describes a protein:
Function:
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
Subcellular Localization:
Cytoplasm. Lipid droplet. Mitochondrion.
Sequence:
PSSAGSTLTAAMARMEQKEEKEKRPHRITGLPLVSSTYDLVSAAYSAHKEQHPYLHSVCGVAERGVLGLAAVAVSSAQPLLTRLEPQIATANEYACRGLDKLEEKLPFLHQPSEKVLSSLPSLPPFSPAGGDLPTISSVVSSARGAVSSGVSGMVDLARRGRRWSVELTSAVVAGGVDAALGTRVGRMVTEGVGAVLGRSEELLDHLLPLSDEELGKAAAPSPRGPTVTSLEEQRRHQTYFVRLGSLSARLRRRAYQHSLGKLRLSKERVQEALAQLHETLELIEYVKQGVDHTFHSSQSKLHQLWQDWSRSRQEDERDGGLRRLQVLTLALSCELTTELQATCETLASSIHGLPPAIQDKVREVRQNVEDLHAAFSAAQSFHDLSGAVLAQGRGQVTQAHESVDELVDYVMQNIPLPWLVGPFAPYLTERPRTPQNLAQQVDEVVPGRRPSVLDGDRWAGMEWQAQAEAWEAEQGLPPQEKKGEEEEEEKSAVAAEEEEEKNPVTPRVVKPRIMPELDF
The following text describes a protein:
Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Sequence:
MERESTCSVEPVSSDRSIDIEHNLISFADVEQWLDDNPECFEDYFLRKGRTESVRKWLSLHHDANEELTAAPVSNKYVQGTTLDSNTSGRPPPSKAHLRHQFARSRTRNVNFATSESGVSVEKEESRDSDRNKDKRIRFRKANSLPPNPSNILSMLLKSNVRLPRVNSKDIEDKRRLKAENEREFFLEIVKDMANDLDLTSLSYKILVNVGILLDADRCSLFLVEGPKGRRELVSKVFDVHAGTNVMPGYVGDNVVRIPWGMGIIGYVAEHGVQLNVPDAYQDSRFCDEVDKSTGYRTRSILCMPIKDSEGEVIGVAQAINKNPDGMPFDEEDVKVFATYLPFCGIGITNAKLFDISMREQERNRVLLEVARDLFEEQTCLDSIVLNIMMKALTLMKCERCSVLFLKNEGDQELSFTKSFNLTSSFSHTSRFSGKMRRVFEPILEDYTLYTVQSSESGSAPLVSNGIMDYVASRGEAVNIPDAYQDPRFDSESDKVLGIRSKSIMCVPIWDNHHEIIAVAQLLNKLDGHPFDEADEQLFKAFAIFCGLGINNTLMYSEITKAMAKQSVALEVVSYHAVVSEEDVESLKLDANPGASSIPVVEDLDLNAFTFNDFLLNRDEMLTASISMFESMGLVNKFQIDYETLCRLMLTVRKNYRNVAYHNWRHAFNVCQVMHALLTNGGMGEDLFSDDPGDQLRQQAGGLAEKMSSMEMLVLLVACLCHDLDHRGTNNAFQQKSQSPLAKLYGTFATMEHHHFNHAVMILNNQSHNIFSNLTNEEYSKVMKMLKHAILSTDLTLHFQIRKEFFSLASSGEFDRNDKKHREMLRGMLMTACDLAAVTKPWEIQKKVAELVTSEFFDQGDKERAELNLEPAALFDRRRKDDLPEMQLGWIDSVCFPLYEALVKVEPRLAPLRDGVMSNRDKWLKLNEERKSSMSVQSDEDRAIAGSTDSGGEDPSSVTAEYREEEALRRSFDSIEEGPSSPKAPPPTPREVKAVHFQEPLFERRGLTSKRHSITGRPFDRRLKVQTSISDRQIIVSRKWRSYEEKGGNGAQS