lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGSTMLPLLENLTASTTMDPNSMMMELYSFIHDWTLEHELELEDRSLVPRDVVRRMSKKDSQCGTVIDMNIDCLVKVLGTNLFLPRVNSKELYNIWPIMYGDYIAYDFWLGKVYDLKKQVVLKLSNGARCSMSTKDASKLCDVCPHASDSGLSFDDSYGFYPGQALIGPSKVFSRVQWLSGVKPVLSVKSKFRVGVEEVQVTELRVTWITKSLGGTDCMDPPPAVITQENLSRVKRLGSFDHTQRQLGERCLYIFPTKVEGTKNLCESFEKNCLLGEVTVTRKQVDKLREKQKVKIISRIASSTTSFQSGSGTGRKKSIPLSIRNLKRKHKKKKKSKVFIEFKHGDRVAVEIITTVTTADVMWQDGSVETNIQSNELVPIQHLYTNEFFPGDFVVDKRIRFCFAPIARAAQDPSIYGVVQCGDHKGRTCVVKWIKLNSEGDDTEVVGEEENVSVYDIVDHPDFQFRATDIVICIGSSDPEAFPDARQPSVGQVACVDVSSKVEVIWADNSRTMVLPQHLYNVESELKKNFYVDSSSSGASSDEWEDMSDSWETDNGLKDSSSSGASSDEWEDMSNSWETDNGLTDSSSSGASSDELEYTSDSWETANGLTDSSSSSASSDKLEYTSESWETANGLTDSSSSGTSSDEWEDMSDSWETDNGLTDSSSSGASSDEWEDMSDSWETNNGLTEDVFPLAAGEEAAATQNENTPAEPLQEPVQDEPEQSAVRSEWPSDTLGTIFTSAKGEVISLLETAPESHAFKKLEFQAPKAKKFLSTVYKEMALLATSLPDGIMVKTFEDRMDLFSAFIKGPTHTPYEDGLFLFDMQLPSSYPAVPPLCRYLSQCRGNLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSNLLQVLISIQGLILVNEPYYNEAGFDRDRGLQEGYENSRCYNEMALIRVVQSMTHLLRRPVEVFQVEICEHFKSNGWRLAHRIENWLETNSMVERGDKLTNGQEHPCIVPYSSTEPECTPDPTLDSKDLDDSGCGASTMSPGESQQLSDLQSTSKGAMGGVTLSEEPRGAAGGGQPSVKPKKHRKSYRSFLPDKLGFPDVGFPLFPLSKGFIKRIQRVLAQYKASLLEVGISEPRGGRLTLPL
The following text describes a protein:
Function:
Required for the maturation and activation of urease via the functional incorporation of the urease nickel metallocenter.
Sequence:
MDREHSALKKMRLEDAEDSAISQVPATASSMHQQLFWSQWQLLDSILPTGGFAHSYGLEAAMQSRIVNNQEDLRLFLIQVLDNIGSLLLPFVYCASRSPEAAAWVKLDQLLDATLTNEVGRKASTSQGSALLRVAASVFTEIQPLQDLRRTFLGSMSVSLHHAPIFGLICGLVGFDSETTQRAYMFVAMRDVISAATRLNLIGPLAASVLQHQVAPDAEKMLQKWKDRDVSEASQTAPLLDALQGCHAYMFSRLFCS
The following text describes a protein:
Function:
Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSANELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDRVLSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEALLAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVSGFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYGMADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVERAIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLLGQLVGSMAPQ
The following text describes a protein:
Function:
High-affinity, proton-dependent glucosinolate-specific transporter. Involved in apoplasmic phloem-loading of glucosinolates and in bidirectional long-distance transport of aliphatic but not indole glucosinolates. May be involved in removal of glucosinolates from the xylem in roots.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MERKPLELESTDNHQNPSSAVYGGSVTAVDSVEEDVQNQKKVVYRGWKVMPFIIGNETFEKLGIIGTLSNLLVYLTAVFNLKSITAATIINAFSGTINFGTFVAAFLCDTYFGRYKTLSVAVIACFLGSFVILLTAAVPQLHPAACGTAADSICNGPSGGQIAFLLMGLGFLVVGAGGIRPCNLAFGADQFNPKSESGKRGIDSFFNWYFFTFTFAQILSLTLVVYVQSNVSWTIGLTIPAVLMFLACLIFFAGDKLYVKIKASGSPLAGIAQVIAVAIKKRGLKPAKQPWLNLYNYYPPKYANSKLKYTDQFRFLDKAAILTPEDKLQPDGKPADPWKLCTMQQVEEVKCIVRVLPIWFASSIYYLTITQQMTYPVFQALQSDRRLGSGGFVIPAATYVVFLMTGMTVFIVVYDRVLVPTMRRITGLDTGITLLQRIGTGIFFATASLVVAGFVEERRRTFALTKPTLGMAPRKGEISSMSAMWLIPQLSLAGVAEAFAAIGQMEFYYKQFPENMRSFAGSIFYVGGGVSSYLGSFLIATVHRTTQNSSGGNWLAEDLNKGRLDLFYFMIAGILAVNFAYFLVMSRWYRYKGSDDEVTTYETNENIIKQQDKNVA
The following text describes a protein:
Function:
Putative hydrolase with unknown substrate. Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (By similarity). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase. Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (By similarity).
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Translocates from cytosol to mitochondrion upon IL1B stimulation in chondrocytes.
Sequence:
MGTPGEGLGRCSHALIRGVPESLASGEGAAAGLPALDLAKAQREHGVLGGKLRQRLGLQLVELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVTSTSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGQPGLPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHN
The following text describes a protein:
Function:
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The coiled-coil domain is required for assembly into the NuA4 complex.
Sequence:
MSSERVRGIQVHRPIIFGSHARLLTEAEKQLAPAGHTHKWTVFLNSAASPPLKQGEPPDYEDIDYLPGGADDLSYFIRKVTFKLHETYATPNRVIDKPPYRVSETGWGEFTVQIRIQLIPESSEKPLGLQHNIKLHHWGAPVEPLPVVSGAPTPTPVPTESNTEVKLEPDTPAPLEESVTPAPTIQRPASEPATNEPGSNQGTPAPPGGDSTEQIKVDVATPALEVIEPSATPAPLSLAARLPIHAWQYDEIVFSDPPRQFLDILNAHPPTPLPAKSRRPRDQREDYEARKKGKSAARGASVTASARASRAGTVDTAAAGTPAPAQIGIPGEPGSADVPLEFTQEMLKGEHNAMLDARVKIVEQMDRWRERLIALEKELAKAKEDVKATAAM
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the second step of the tubulin folding pathway.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton.
Sequence:
MSNENEKSIVEYFYIGERVKGDDGSVGTIRYQGKVDGFEGNWYGIEWDDPKRGKHQGTVKGKQYFKCINKGSGSFMKYEKLIKGETFMKSISDKFHQKIDNYDDLYVDSTKEDIKIQIQMIGMNQTRENQKKFIAQTLLSASYLPISEIDESPLIYNNFKNLIELNLSNCLLNSWTQIVKLLKQLPNLNRLHLCNNRLSFNIDEFKKEVNSNNEYGNSIDDCNVKDLILVNSNLSNWSIVSSICKYLFKNIESICLSSNSIENINLFKSILNNDNENENENENEIVEQQQQQQPQYLFPTLKSLDLANNNIKSFNDILSSLGNLPQLTELNLNNNQITDIEFNGDVDDGNKSNNGKTNQFKNLKRIYLSNNKINDWKYLDKLDELQSLDELSFRNNPIVDSLLISNSNNSNTNENEIENDIENNNNNIKKDNNNNNKNNKNNKNNKTIFLNRLNIIPRLSNLKKLNLSDITLLERKDAELYFLYENYNSIDKFKNNKKLNYLISIHGEPVYTKMSLQLEKEENGK
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MAEEGDCANLLLNITCNPSPMVTTADPTRKKDKSKGSKRVRTNKMVTKQQDVAKTRTTIDTSNFKRKLTDNSSREDMNKGTVQSTKWISSLFTNNPEIPQVQRSKKLKTHHQVFTDVEFTNVALSPRLVSHLEQHFHYQKMTCVQRKAIPSILNGRDCLIQSQTGTGKTIAYAVPIVNKLQELEPKIQRSDGPYALILLPTRELALQTMTIFNKLLKTFCWIVPGCVTGGEKKKSEKARLLDLGFKEDINTMLTALNAGSGQRQTILVSATLTAGVQQLARLALQDSCYIDATSTIPEDEYNATTIPSDSVHQIPSELQQHYVVIPAKLRLISLISFFIHSHKKNKKTKSIVFLSTCDSVNFYYNILNEFLPRFLTNEIEISKLHGNISQKDVAARGLDIPDIDWVLQYNPPIQVTDYLHRIGRTARIGYKGKSLLVLLPSESYQLAASDLQMSIENFVNSSAERKTQAISAYQSYIRAYGTFSKSLKFIFHVRNLHLGHLAKSFGLQEAPSKIKHQIITNPIVVIGLLECFDGLLYTIYE
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin (CaM) calcium sensor proteins to cortical microtubule arrays, thus being a potential scaffold in cellular signaling and trafficking. Binds to microtubules (MTs) and promotes MT assembly and dynamics to modulate pavement cell (PC) morphogenesis via cellulose deposition-dependent anisotropic cell expansion triggered by cellulose synthase complexes (CSCs). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Localized to microtubules (MTs) arrays in dynamic pattern, including cortical MT in leaf pavement and hypocotyl epidermal cells (in a discontinuous and punctate manner corresponding to indentation regions), as well as preprophase bands, mitotic spindles, and phragmoplasts of mitotic cells in root tips.
Sequence:
MGASGRWIKALVGFTKSDKSRSSKKDENVKVATKSRFGRKNSVDFDFEKFQDGFEDSNTRSMVDTGVSTSTSLQSYGGVAYDEQSRENRAATRIQTAYRGFLARRALRALKGLVRLQALVRGHAVRKQAAVTLRCMQALVRVQARVRARRVRLALELESETSQQTLQQQLADEARVREIEEGWCDSIGSVEQIQAKLLKRQEAAAKRERAMAYALTHQWQAGTRLLSAHSGFQPDKNNWGWNWLERWMAVRPWENRFLDSNLRDDAKLGENGMEQSENVPKTQIKSVSKMPNTSNLVSGVSSQMTGPCQSDGDSSSPGISSSIPVVSKAKSKPAKDDLAVEVNSRPGAGPRSHSNPKERSREPNRSSKERLSLPNSGKSLGSQSTKANRAGKLTPASQKVVEEKSAQNQRRRNSDPIKQRLA
The following text describes a protein:
Function:
Plays a key role in the degradation of rhamnogalacturonan in the cell wall. Involved in degradation of pectin.
Subcellular Localization:
Secreted.
Sequence:
MKSIALTSLSLLPSALAQTIYLAGDSTMASSTPGWGDYIADSVSVEISNQAIGGRSARSYTREGRFQAIADVLQAGDYVVIEFGHNDGGSLSNDNGRTDCPGDGDETCETVYNGVAETVLTFPAYIENAALLFLEKGANVLISSQTPNNPWESGTFSYTPNRFVGYAELAAQRAGVDYVDHGAYTASIFEALGADTVNSFYPNDHTHTNAEGSSVVADAFLKAVVCSGVALNDVLTRTDFDGECL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MASAAAPLPVPKVEDAAAQEPSNEVVSPADALYDKCAERPQGTVFFQRDLSNMQVAETMAELTMLLQDLCDRHLLKLMTLEGEPCWKLRSRTDADKLRRLTPDERLLYHHIDQVQAEGIWSKALRMRTNVTQQVLTKCLKSLESKDLVQSVMSVKFPNRKMYLLKHLKPSEDIAGGPWQSEGDFDTALIDAISSVIAQHIENETCVKVPGNWNDYGQHDRAAEIARKKAQVQGVRDIEEAPAVKPYSRDPSSSKLVHKNSPTYPTAASVATWLNSKEVLRGKTCREDDMEQLLEMMVLDGRLEKISGTNYRTVLTAVDSKVYNGFVDAPCGNCPVFDLCGDEGEISARTCVYFGQWLETQSEEI
The following text describes a protein:
Function:
Involved in HMR and telomere silencing via the recruitment or stabilizing of the SIR (silent information regulators) complex.
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTEIIDLDLVDDFIKKPMVKQQKNQSSKPRVKRRGQLTFDDFRNIKIVEEPVVLSHNSSIDESLDAATQNTKKREKYEGTCDEEMKTKEMEANMASKYSNIKTHSNDTNKVESISEHTTSNNRPLNTLNWSPNIPLRYSDFAKFMSDETVTESNWAPPLCTPLPYAGDVMKILSFIVKFKWVFSDDLLNLSFQDVEIGLELKVAGHSAKNIRICQDKMNLLFCSLLRLLFCSEKRADNQTHRNFTLKRFLSLKNPYGKLVGKLRSLIQEWGLPKEWRGNSDILSTLNFNGGGLLTMEPLDRIILLRCMIDWNCSYSALFHNEIQRLTHLKGDTGFNHQTFHASRFAMCGANNILDSCEVLCSLMSQKLENRKKRKPSDKGKLSKINSQMKFLKGVRKSLSEKVTTDRLRAAVKINEEWGEYFANEFTHTPIDDPTVDEIYKLRTSEFMIARIPRVGDFYLPPFWIGNECSSVNTSYSFNDMSTYLNYFVKFKEEGTKILPAKTAQNENKCQLKLIYRNTPACIRNLQFNDVHFAEVPHWFEVAGDSNSLSNFIEYLESLSSLTENDTDDTKKGIDNLIEFLKIFSIFINETIQRITAAPTGSTEGRHLRTSSQRRTTVHYSSDVNGDVSEESENEVDIDVSDDYDSEYLSEENTLTRKGEDRTDKSFGKRELHNGAKDCDRNCDDIEIFSEPVRQLQDNSREKRSLRRNARKGL
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MISLCQIIHNSKNTDLIKISKRLSWLLRHGAHKSGVLMTTDGYVYIDEILALESFKNVKLDQIKEIVDTNEKKRFVLNKDCEGKLKIKACQGHSIEVPDLELTPITKSSDVPVVLHGTTKQAWQSIKDEVGYRGSSNVLISIDLDKALKDGLQFFRTPNNVILSPGNEKGYISPSYFKFVNFI
The following text describes a protein:
Function:
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme.
Sequence:
MALRCPDLPFLPGYTFNPMLGKTKFNMDPKFDFIGDGVPALVEKVRPNMFGPLSDKYPSLYPRGEVLELPSWIAFDKQILCFDAFFKETLQEVRGAPFSLRRVKIYFFLEDGTIQVIEPKVENSGIAQGTLICRHRIRFPAPMDDNFYEVVDLNVGKEVEFYGRVFKITDCDKFTRNFLNRCGIHVPDSLNIPGDPFLELRNQENARIKKRGKKKDDSLGKFLENDRKVLRFYGYWDDQETVFGYLHRLEILYYLADDTIEIREVSTEDCNKKTTFIFLHRDKIPKTYKELPMPGANCASTVLNVLGPGLQGGRFIKDPLSCGVEVTEYYCEKDLFIGSVINCYGRKLVLTDCDPYTREYYRSMYGLNSLDAIAFPEDKHAGVKVEQKERELPPWNGYGSYEDSAQNCITVEPKAPHRDFKKFLNLDRIGIDSHILRFEARMLSKIPENCTRHFVISYYLADDTIAVFERGIRNSGFDTKEFFARRSVALPNQGVYTSKPPITYKSQDMYVGATLIINSFKFVLIDADEYALRYMEIHDHQYPKANIKVIMGKIREKLRPTYKDFVAENMPKESTTIPYDTLKAKLLGILGDDFTEHEMITIARAFPGDVDLTEKYDREKIRAITLTELKRGLWDDLARLREYFLMRDPHKSGVLPRNECYIVLRACRLPLEKELVDKILQVIQKDNEGNLCYEDILNFVNRDICKLPDVEPISLKHELSCIKVIEYEKYKLINWCEFNKFLDLEDTFKEQPVNNTIERLQKNK
The following text describes a protein:
Function:
Acts as a component of the outer kinetochore KNL1 complex that facilitates microtubule-kinetochore interactions and the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MADDPTINGLELQLNAAEEHATALTEEALQNQDLHYKEVVEQLKRSVEQLVEDNESLFTAVDLPPEVDPTCISGRILDLAQLTQQLKSTHLQQETLDNFLRYTISSTDILQLESESDERYASVSRAVSQLQDNDIIQLDSEVDQIKQDIRKAGQTIADQREALNELCLETGNLADECHTLLSELEEATRTREMVEKQAAVEVTNDHPVEEMYASWQSLKEELQQESHLRRHLNQLKQSKASLEAILGTKNGNEHKDTNVMQEYASYDAFIRFWISKFTNKEMENLEVFPRSNKFQFTHRGTDVVISLGPRGISRVELYGKGIPLEKIAAARKDVNEEASRGEELYMSINRIIDKIKEHTTVS
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Subcellular Localization:
Nucleus.
Sequence:
MATTSSFSKGCFVFKANPHKSGRSPRKKTKKSAIVDTHDDLNASSLFAKSDKSSMEIRLDSYKKIWSATKKKSEEIISNSHKQLLHDVKTFVSENACTGQSSIPTALISLGVNLPDHAAFFSLLDTTLKTNVSPFVAMLNSKECPSLKNMVLKTIQKITSCDSIDDELENDEEDDEDDEIVPIKPRSKVKTFANLATWYSNVVMKTPLIIILQDLESFGTQQLQDFVLLCRENRVRNKLPIQFIMGIATTVALQQQLHHRTSVCLATKSFQSRPSVVLLNHLIEQLFMKSSVLKLGPRLMQLLLDGFLYHDLSLNSFMMRVHLIIMQHYITLPVSSLCCSVSELKNRIKQLRAADLDLYRQLPSFMKFIENNRSKISLLTDDKEFRLFLQKSLEALNTYSKNFSLSCRIIHSLSDGMPDALFGKSLREVYVNLLIGGESEDWEQFIRLLNVSSAHELRTRIEAALTTLKECDSSGSLSDFSTSLVLFSEELLRLEESKKSDAVTSPKSQNVFVPQGKKLDKFELKALMATAKQVRTTSEFDEVKSEIITWLNSELASRLKSPSTLVFHEIFYAGSQVQSNWDIVPWIRRQVQPVPRVAISKALSNPASYLGCSCCSLTGQETQVLSSMPDLCIVYKLHTECGRLINLYDWMLSFNAIQKKDNEDDNEEIEPIIQARFIRAVAQLQLLGFIQSSKRKTDHVARLTWGV
The following text describes a protein:
Function:
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
Miscellaneous:
MISCELLANEOUS: Present with 26000 molecules/cell in log phase SD medium.
Sequence:
MPNASQVYRSTRSSSPKTISFEEAIIQGLATDGGLFIPPTIPQVDQATLFNDWSKLSFQDLAFAIMRLYIAQEEIPDADLKDLIKRSYSTFRSDEVTPLVQNVTGDKENLHILELFHGPTYAFKDVALQFVGNLFEYFLQRTNANLPEGEKKQITVVGATSGDTGSAAIYGLRGKKDVSVFILYPTGRISPIQEEQMTTVPDENVQTLSVTGTFDNCQDIVKAIFGDKEFNSKHNVGAVNSINWARILAQMTYYFYSFFQATNGKDSKKVKFVVPSGNFGDILAGYFAKKMGLPIEKLAIATNENDILDRFLKSGLYERSDKVAATLSPAMDILISSNFERLLWYLAREYLANGDDLKAGEIVNNWFQELKTNGKFQVDKSIIEGASKDFTSERVSNEETSETIKKIYESSVNPKHYILDPHTAVGVCATERLIAKDNDKSIQYISLSTAHPAKFADAVNNALSGFSNYSFEKDVLPEELKKLSTLKKKLKFIERADVELVKNAIEEELAKMKL
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGGNEITVVMELKLEEDEDEFRSCCADEEELDVEEITKQGLKFCTDDEFLDEFSVRMFFKGVSISNHGNNCFNVSGIGVVMEGANKVPVIQVQKKLDFFVDESVADYLALMEGLLEATQNNIKRVFAFTDSTILFHQITTEKTLENPLHMALKQRVLEHVTNLDHFVLKYIPNVLEALHLAKVAIGMIHLPIKGDNSVQKCSICLEEKPTPITITMKCSHKFCSSCIKSHVEEKLESSQLPVKCPCVNCRYYISTPEFKSFLPVVSNTLLEDTMNSIGGDKFYCPFSDCSVLLDPCCDLNDNNNCVECPVCRRFICVKCGVTWHASMSCDEFQDRPPVAVDGGGGADIGRWRRCEMCERMIELTRDHMTCWCGHEFCYSCGAQYIDSEQTCECAILGSDGGGENDEFTLTQNIGSSTAIEEWAWDSCGSLSNLMDAYSDQERSQLALIQRFLAGGFSLGDHHTSMYQSQSQSQSQSPPHQCTDSGSSYLDNTMKDLHQLPWLERFVSVISDNYYEEYTQ
The following text describes a protein:
Function:
Catalyzes the reversible oxidative deamination of L-glutamate to 2-oxoglutarate and ammonia, thereby playing a key role at the intersection of the carbon and nitrogen metabolic pathways. Shows a high preference for NADP(+)/NADPH as the acceptor/donor over NAD(+)/NADH. May function in vivo in the synthetic direction. Also catalyzes at very low rates the oxidative deamination of L-2-aminobutyrate, and the reductive amination of 2-oxovalerate and 2-oxobutyrate.
Sequence:
MSQNGQFLEYTLQVIRRGVEMGGFPEDFYKLLSRPKRIIQVSIPVKMDNGSYEVFEGYRVQHNDALGPFKGGIRFHPEVTLADDIALAMLMTLKNSLAGLPYGGAKGAVRVDPRRLSRRELEELARGYARAVAPLIGEQLDIPAPDVGTDSQVMAWMVDEYSKLAGRNAPAVFTSKPPELWGNPVREYSTGFGVAVAAREVAKRLWGGIEGKTVAVHGAGNTGAWAAYWLEKMGAKVVAISDTRGTVVNKAGIPGEQILKVYMEKKRDKSATVLALEGEKIADSNASLYQDVDILVPAAIENVVREDNVGLVRARLVVEGANGPTTPGAERRLYERGVVVVPDILANAGGVIMSYLEWVENLQWLFWDEEETRRRLEAIMSNNVARVYARWEKEKSWTMRDAAVVTALERIYNAMKTRGWI
The following text describes a protein:
Function:
One of the few identified sugar gustatory receptors identified so far with glucose being its primary ligand and which mediates acceptance behavior.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSRTSDDIRKHLKVRRQKQRAILAMRWRCAQGGLEFEQLDTFYGAIRPYLCVAQFFGIMPLSNIRSRDPQDVKFKVRSIGLAVTGLFLLLGGMKTLVGANILFTEGLNAKNIVGLVFLIVGMVNWLNFVGFARSWSHIMLPWSSVDILMLFPPYKRGKRSLRSKVNVLALSVVVLAVGDHMLYYASGYCSYSMHILQCHTNHSRITFGLYLEKEFSDIMFIMPFNIFSMCYGFWLNGAFTFLWNFMDIFIVMTSIGLAQRFQQFAARVGALEGRHVPEALWYDIRRDHIRLCELASLVEASMSNIVFVSCANNVYVICNQALAIFTKLRHPINYVYFWYSLIFLLARTSLVFMTASKIHDASLLPLRSLYLVPSDGWTQEVQRFADQLTSEFVGLSGYRLFCLTRKSLFGMLATLVTYELMLLQIDAKSHKGLRCA
The following text describes a protein:
Function:
Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (cob) gene, containing its own coding sequence.
Miscellaneous:
MISCELLANEOUS: Encoded from partially processed cob mRNA that terminates with the in-frame coding sequence of the third intron.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MRLLKSHPLLKLVNSYLIDASQPSNISYLWNFGSLLACCLIIQIVTGVTLAMHYSPNVLEAFNSIEHIMRDVNNGWLVRYLHSNTASAFFFLVYLHIGRGMYYGSYRAPRTLVWAIGTVILILMMATAFLGYVLPYGQMSLWGATVITNLISAIPWIGQDIVESKIITLIINLSFIAILFSIVVVYYYILLHVNFSSNLPTIGVIHQNALKKSNKALRLDKQEYISIPSSFLAFLAGLVDGDGYIQVTKTSKGFIAIKLVISLHLEDLSILEYIHSVLKIGKINIYKDLRSPTCKLVINKTDLQEILFPLLMYNKIFFLTNTRADQFNLAMYIFKNDIKMYNQIPDNTPAVFEIPKNPIDYTLLPFFKNWIVGFTCSEGSFFIKSNNDGCFQLKQRIHTNLFEAFKLMFNTNRKIDTTNNFNQFGVSSKSDIQKVINFFSFSGLHPLVGLKYIQYIKWLNNLRESLRYSTLNYPDAK
The following text describes a protein:
Function:
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Also displays oxidoreductase (thioredoxin) activity (By similarity).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MPVREVSRLPELNEILEKSDSNRLIIVDFFANWCGPCRMISPAFERLSMEFGNATFLKVNTDLARDIVMRYSISAMPTFLFFKNKQQVDSVRGANESAIISTIRKHYSSTPANPNAASDEEKKFLERFVGYTELRKMHTDEVFKALARSVMPDGISDRLENGEDEKKVLQELLDWFKNDFFTWFDRPTCLKCTLKCTTEGLNGTPTKEEKEGGAGRVEVFICNGCNSEMRFPRYNDPSKLLQTRTGRCGEWANCFGLILSAAGLENRFVLDTTDHVWNEVYLKKEQRWIHVDPCENTMDRPLLYTRGWKKQLKYCIAYGHDHVTDVTWRYVFDSKKLVTQERVRQGVLENFLGKLNARQMAGATEERKRELAVRRVCELMGMMVQEAKNQRIGWEKLGEDMGGRTTGSKEWRRARGELGDNPEAQVLGKPIEFRIQNDANHVEFSYDVNRDSYSQTPEKGFVAQTFECNNIQRKVENDWKMVYLCREDGKKEGNISWHFNLAPLVATDSKKTIEKVEIRMAGIRKFENGNILIIACLGDTCMRIPASGNLTIEDPKPEVLKITVTLSGGERNQAFQHAQLFRTEKDDVAEATESMVVRVYMK
The following text describes a protein:
Function:
Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes; Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage; Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus.
Sequence:
MLNCNNNNGMGAAPKPFPGGTGPPIKAEPKAPYAPGLPTHPSKKRKHSESPPSTLNAQMLNGMIKQEPGTVTALPLHPTRAPSPPWPPQGPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESDSDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDTTEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANGKTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGSSGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSVVSMSTLYVLSLRTEEDLVDTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLRQSPLTTGLPGIQPSLLLVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSLGPSFNPGHVLSPSPSPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLASPAVPFPGGQGKAKNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQVLENSMSITSQYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSKEEPCEEGSLPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPATDYHFHFYRLCD
The following text describes a protein:
Function:
Has deoxynucleoside triphosphate (dNTPase) activity.
Sequence:
MNNTFKYVNEDVSGTEGEESDYDPSEFIRGYHESPRSPRLIDYEMGRGLMGNFKGLGINKVRQSNEYDNDTDYSSRKSSKIINDVIHGHMEVPDYIMDFIDTEQFQRLRDLKQVGTTSFVFPCASHSRFEHSIGVSHLAGKYIDRIKVTQPELEITEREQKFVRIAGLCHDLGHGPFSHAFESWVDQLGGSKRFHHEDMSIKMLNWIIDDHGLDEYDSDDIKFISSLIQGKHRPKERAFIYDIVANNRNSVDVDKFDYLSRDSYYLGRSTVCDFQRLMEFSKVIDDQICFLSKEIYNLYELFHTRYSLHKLVYTHKVGKSIEFMIADAFTEADQFLKISDQLEDPKEFINLSDSLLRRIETSKEPELEKSRKIIKNIRNRNLYKFVDEIIVSTDKIRWSADSLAEDIAKVGNGILESDIIVQNLKLNYAFKDKDPVQSTRFYTRYDSTQSFTIKKEETSHLIPNQFQEERIRIFCRSKEKCEQVQTAFRKLLKNHNLSPNPSFTVSPARNIKKI