lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular Localization:
Cytoplasm.
Sequence:
MSASRSRNKQSKLCDDERLDISRDEFNRFQEAFGKEEFRKLFFDYVDEIQDPENRKIYESEITQLEKERGVEVRFIHPKPGFVIKTALDGELKCFINIASCEEIQRPKNEVATDPSSGSRGLSWSIPMAQTTSRDDFDAKNNHCKVFDVVFHPDALHLAMRNKQFRQCLIDTALDAIEREYKVSLDRANLKFPKLDYKGIPRPTVIRKMADNPTAEEQEPHPLAHMFPTKPPAPGKQEPRVLPMKTKPSPVPEFTVPRYTIKHSHDVDLSEYTDELDAKLHVTVPRSLVVEIELPLLRSTAECQLDVTSKSIYLFSERQGAKYRLKLDLPFIVDDKAGRARFDTDMRRLSITLPVVRKSIQEQAQMHETLRHFSREDSGVELHSNSESPVEEDPDGELSDSKADISETSSPSVAPANSPFLKSSVHYQLPSKFDCNVLDNVMAFVLHVPNVQPDSIEQLREQRSLHLKFATIGSGYYPTHYAFYVELSAEHEDSSIESAEAEAWDNNVVLKLCLNSQSETPASYLAGLDATELKEYPVHGQYHVKSKGKVNAKKDNAPLDVKFERNQEGHALKVTIRPGTKEEEEDKENQDQEPESDQQQQQQVQNKKPGKKQRKKNKKERSLSESACADMILQEPLAKTNELQPRATFKLPPQRKQRSYSECNDSTGRSHRGILKRFSRYGPRPSMSDSWSSIDDSSSYSCSVDASGTSLFSQSFGGIPEEDRSDAGLSESCKKTVRFNDHIMKQVFRLDSSILGQRKKNQKRRDLKLRAQQRRLSEGDSVDYEETRGSALKQEENPSRNCNDSGLDLTGAAGAHSNNNESDAKNTMMFEMDD
The following text describes a protein:
Function:
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.
Sequence:
MIRKCTEHGYFRGGSCQQCKRPGRYVLDDSREEKLGRFVSGTLRHFPASAGVKMDEYGWVDLNAFCDVMKKRYNWMRKEYLYALVESDEKGRYQIRGFMIRARYGHSVNIELDYEESDAPYVYYGASPEEVDVLLENGIFPIKQRYVHLSTSYEKAAEVALIHTESPVILQVDAFRAQEDGISLKLATDYIVLAEKIPPEYLYVIEE
The following text describes a protein:
Function:
Essential for male fertility, sperm head formation and sperm penetration through the egg zona pellucida.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MSLHGILASAGTIGAVAAWLMSYKPALFGFLFLLLLLSNWLVKYEHKLTLPEPQQDEILQRLLFSEMKMKVLENQMFIIWNKMNHHGRSSRHRNFPMKKHRMRRHESICPTLSDCTSSSPS
The following text describes a protein:
Function:
Thiol-disulfide oxidoreductase that may participate in various redox reactions. May act as electron donor to the BAS1 peroxiredoxin. Possesses low insulin disulfide bonds reducing activity.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASTAAFLSTLAGSTSLGGATPASGGGSGRSKTARFLRRRRRGGAVRAAVSGTEQAPETTKKKGGGGGGGDERVVQVHSAEELDGALRAAKERLVVVEFAASHSVNSSRIYPCMVELSRTCGDVDFLLVMGDESDATRELCRREGITAVPHFTFYKGAEKVHEEEGIGPDQLAGDVLYYGDHHSAVVQLHSRADVESLISDHRGEGGKLVVLDVGLKRCGPCVKVYPTVVKLSRTMADTTVFARMNGDENDSCMEFLRDMDVVEVPTFLFIRDGDIVGRYVGSGRGELIGEILRYNGVKVT
The following text describes a protein:
Function:
Mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence:
MYFQNSTQLGWWFLAELIGTFILIIFGNGAVAQVNLKKMATSETKAKFLTVALTWGIGVLFGVLTANAIFKGSGHLNPAISLFYAINGSIKSPTALIWPGFVIGILAQFLGAMIAQTTLNFLFWKQLSSTDPQTVLAMHCTSPSVFNITRNFLTEFIATLILIGGVVAASHFLHNNPNSVPPGFMGLWLVAGIIIAFGGATGSAINPARDLGTRIVFQLTPIKNKDANWKYSWIPVIAPLSAGLVLSIIIGFSPAPVL
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIGSISICTRNAVPLNLRTQMGSNICTVLSRRTSTSCCSYGISRPKYADQSVTTISSCSPNTSQRFQAGGCLSTCFSRRSIDFQAFTVKDLITDGGSRGRDVEISLACKGMNVKLSIPNDGTFSKIKYNMRWPERWASAGLVFGWVVCYSTSEPVHAEAAYEKDDNEENSDSSHVKLSHGKKVYTDYSVIGIPGDGRCLFRSVADEFIKRREETEWFVEGDFDTYMSNMRNPHVWGGEPELFMASHVLQAPIIVYMYDKDSGGLISIAEYGDEYGKENPIRVLYHGFGHYDALQIPANQGVGRSKL
The following text describes a protein:
Function:
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Subcellular Localization:
Cytoplasm.
Sequence:
MRKVLVFLKNSKKAFETFKRVERVLKDLNLSYKKFINRKELFKVLKPKDYELFLVIGGDGTFLSAARIASRFGVPLVGVNEGRFGFLTEIKKEEIKKVLPLVLEGRAKLQERLMIDVYLRSRNRLRYLGNYLNDAVISKSSIARIIRTKVFINGEEVLEVFGDGVILSTPTGSTAYALSAGGPIVYPESQNLLFVPICPHTLSNRPLVLPSKFEVKFKVVSENMEAFLTLDGQEGFHLKKGDEVIVKRSRYVCRMYSHPRKSFFGILKEKLRWG
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Subcellular Localization:
Cytoplasm.
Sequence:
MAFGGPKKQLYSETICSLCLNLFQDPVLTHCRHNFCRVCIIRHCQESPAPALCPLCRATVKLRNLRPNQQLANIVETIRKAKRGKKAEGRIGVCKKFFCKNDQVLICVVCDTSMEHWGHDVVPMEEAAQEYKDKFEALQQSLEKKRTTAIERKLAEEEKKQTFLTQIKLEKDEITSVFKEMQKFIKAKERLWLDQLGEMEKETEKSWEENITSLTKEIGRLSTLISEMAKKRQQPPIRLLQVSVNSSFVSWYQEGLLRQVVELSPRPEKRLRSYSQKRPVLLKAMENFEGMYFSVFSFDCSVVNVILDPDTAHPFLILTEGLTSVKWEDRYQDLPDCHTRFNREFCVLGQERFASGRHWWEVEVDEEKGAMWALGVARESVRRKGIFKFTPNEGIWAVGKKPYNSPSPCRLSVLNSPEWVPLNLSHEPRNIRVSLDYEESRLVFFDADTNKLIFAFSSVSFHDERIQPFFWVGSGVRLNL
The following text describes a protein:
Function:
Required for the use of extracellular DNA as a nutrient.
Sequence:
MRVKRWLLAGIALCLLTGMRDPFKPPEDLCRISELSQWRYQGMVGRGERIIGVIKDGQKKWRRVQQNDVLENGWTILQLTPDVLTLGTGTNCEPPQWLWQRQGDTNEAMDSRTTVDADTRRTGGKAAKSDADGG
The following text describes a protein:
Function:
Orphan nuclear receptor. Transcription factor. Modulates expression of target genes, such as Period protein homolog lin-42 and microRNA let-7, by binding to hormone response elements (HRE). Involved in promoting oscillatory expression of the primary transcripts of let-7 and paralogous microRNAs miR-48, miR-84, and miR-241. Plays a role in normal development and required to regulate each larval molt. Involved in regulating both the frequency and number of molts, acting as part of a negative feedback loop with the let-7 family of microRNAs, perhaps contributing to a self-sustaining molecular-genetic oscillator. Positively modulates expression of collagen and hedgehog-related genes. Involved in development of the gonad and associated epidermal structures. Required in spermatogenesis, acting following the sperm/oocyte cell fate decision, downstream of the canonical sex-determination pathway. Involved in regulating formation of the sperm-specific fibrous body-membranous organelle (FB-MO) complexes, acting independently of transcription regulator spe-44.
Subcellular Localization:
Nucleus.
Sequence:
MACKVTGPNRHLTSVLEMSSFVYWPRSRQQAHNFPMQAVEQKLADATRTLHAKSSLQPSLSIETPKSKENDESGCESSNCMFHPHTIKSEPNFCFAREFKSVPDDFRIGGGDLQMGNNSKRLTCVIDTNRVDMAGILPDNMSFRGLPENKSLLVSAQIEVIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSIVNYQCPRQKNCVVDRVNRNRCQYCRLKKCIELGMSRDAVKFGRMSKKQREKVEDEVRMHKELAANGLGYQAIYGDYSPPPSHPSYCFDQSMYGHYPSGTSTPVNGYSIAVAATPTTPMPQNMYGATPSSTNGTQYVAHQATGGSFPSPQVPEEDVATRVIRAFNQQHSSYTTQHGVCNVDPDCIPHLSRAGGWELFARELNPLIQAIIEFAKSIDGFMNLPQETQIQLLKGSVFELSLVFAAMYYNVDAQAVCGERYSVPFACLIAEDDAEMQLIVEVNNTLQEIVHLQPHQSELALLAAGLILEQVSSSHGIGILDTATIATAETLKNALYQSVMPRIGCMEDTIHRIQDVETRIRQTARLHQEALQNFRMSDPTSSEKLPALYKELFTADRP
The following text describes a protein:
Function:
Essential factor involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation.
Subcellular Localization:
Nucleus.
Sequence:
MEEEDDDQRLLHSLGVTSANIDDIERKILSQAKTDPKKGDAEASGPPAGGDQETKLTTPQDDAQAKLHQKLRSVQLEIDAVASTLGGAKQAAGKKSGGGGSGRADAEDKKKKKEKVKEEENADEDAPRGGALQQALAAERLRSLKRAKVQIQREILQSGPGPSGSGNQKDKMLAMLVEDEPRRKKSLKPPGGPKKKSPTRRLKTVTYDDDDDFDAVLDGASAGFMETEREELIRKGLLTPFHKLKGFEKRVECPGTSSRQNDSAEQAQETMEASSIAKVAQAMQNMAQSRPTTKLLDAEFLPKLDAPTAPFQRLGVPLKRPGLPSSDERKNKRLKSKTKRPLPGKKWMKANSKKESLLDVADEDVGDAAASASVSENEDEVIEDSDGLPPVILEGGLRIPGSVYTQLFDYQKVGVQWLWELHCQRAGGIIGDEMGLGKTVQVLSFLGALHDSGMYKPSIVICPVTLLQQWRREASKWYPKFKVEILHDSANSSSKKGKRYSDSESDVSWDSDQEEVTRAKPAQKWDDLISRVVNSGSGLLLTTYEQLRIIREKLLDVEWGYAVLDEGHRIRNPNAEVTLVCKQLQTVHRIIMTGAPIQNKLSELWSLFDFVFPGKLGVLPVFETEFSVPITVGGYANATPLQVSTAYRCAVVLRDLIMPYLLRRMKADVNAQLPKKTEQVLFCSLTQEQRATYRAFLASSEVEQIFDGNRNSLYGIDVLRKICNHPDLLEREQAAQNPDYGNTERSGKMKVVEQVLKVWKDQGHRVLLFAQTQQMLDILENFLTARDYQYRRMDGLTPPKQRMALIDEFNNTDEIFIFILTTKVGGLGTNLTGANRVIIFDPDWNPSTDMQARERAWRIGQKRDVTVYRLITRGTIEEKVYHRQIYKHFLTNKVLKNPQQRRFFKARDMKDLFTLQDDDKNGSTETSNIFGQLSEDVNIGAPDGEERGEGSSALPTSAEAEPSVDGNRKSDLRSDQADEESNILKSLFDGQGVHSAINHDAIMSANDDQKLRLEAEASQVAHRAAEALRQSRMLRSRDDFAVPTWTGRAGAAGAPSSVRRKFGSTLNTQLVSSLQPSEGSSSSSSRVQSLQVGALHGKALSSAELLAKMRGTREGAASDALEHQLSLGSASNQRPGSTENGRTSNSNSSRNMIVQPEVLIRQLCTFIQQNGGSASSTSLTEHFKNRIQPKDMLVFKNLLKEIATLQRGAGGATWVLKPEYGFLEDGVDFELKLHLLWFLLRKYYSGVSLNSGWWQVIVVNNYFRALFSPSSVYIFPS
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Sequence:
MKEACIDGGQDPSGFKVRIHGCGAESDPIIDFEADSMGVAISNTTSPRRSTIEEVQNELCPPPQFYLPIHDHESFTTLEYTIYVENGAGKHVPTTIFIDLKPTVIDEVRNAAYHRLFYPKQLISRKKDAANNFAKGHYNVSKEIVYLCLDRIRKLADNCTALQGFLVFNAIGGGTGSGLRSLLLECLSVDYGIRSLDAGEGMEEVDFSEAPEDLLALEKDYEQVGAKGVDDEKDGEEY
The following text describes a protein:
Function:
Forms chloride channels.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MTVPYSSQVATSSFSCFLKLLFRWKGSIYKLLWKEFAVFASLFYSLSFLYRFILSGESKTFFEKMAIYCNEFSNLIPLAFVLGFYVSIVVNRFWEQYRTIPYPTRMAMFVSALLTGFMLPNEQEILEKMSTTSNKYFVPLVWSASLVLRARKEGRIKDDFSVKTLIDEINDYRGKCGTLFGFDHVTVPIVYTQVVTIAVYMFFMSCLMGRQFLENGRVGDMYFPFFTFLQFFFYMGWLKVAESLVNPFGEDDDDFDINGMIDKNLPMSYLIVDEMHNDHPELIKDQYWDSFNITLPYTEASQKFQKEEHVGSAANIDIPQSKAQFIPPSSSMSTLHEDQVISAFSSRQSSINEHKSPKNKRKKVLRNASKLSNFFRSSSRQTSRLDPTKEDEEANLDIPLNPMNEKTNANNDNTINDDRPAAGDDVVKSAPSDDLMFQMSDDEGPPSPKTDSTDTTTAAATKKRFKITKPLSIKDPSRTNQKSDLTTPTKSPDDKPAASSLNSTSGSVSAAGGHSKLAPPHGVLEAVLEASESPEAFVGSVISQLKEIRMGTSVNK
The following text describes a protein:
Function:
Catalyzes the conversion of chorismate to isochorismate.
Sequence:
MLHFYQAVAQLMEHIRGAKAHDVRFTQPLADKPPFALIDWLDAQPIFPKFYWQSRDTREEVVALGQVYTFTDPAPAYAILGDEQRVWGGRSFDGHTAKNPRCMSSFFFLPQIELIRRDEQWLLAVNINNEPQRTLTALQKLLVEVPTLRSMTAHVTRVEHTPTAANWHDLVEKVLAGITEKQFKKVVLARKTTLTLDAPLSAAQLLKASHAQNHHSFHFLLALDSRHSFMGSTPERLYLRHGQNLETEALAGTIGRGANATQDMELAHWLTHDSKNLNENQLVVEDIIESLAPHAEQIHTQREAQLVRLRKVQHLKKRIDAQLKSGVNGVQLLGVLQPTAAVAGLPRQAALAFIAENEPFARGWYAGSMGYFSHAQAEFCVAIRSALVVDKQVQLYAGAGIVPGSIAEHEWQELDKKLSTLLSLITDRLPLGVAS
The following text describes a protein:
Function:
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKRGRTEEIQFGQPRVQPPTGQQRIITTTQPHNVASSTGTTIQYQIPPNVIKTATPPDSVNSVTNLSTQQQQQQQGTQLVAPQQATSVQYTTTYNTTLGSNLVKTQQTTNPQQQQIHVVNASNQVRGPTHKSTVVNATAVATNAGTANSNSSVVSSGGVTAGGGQQVITTSMSPGVLPGGGGGAAQGPPPPPPQGQAQLQRLKVEDALSYLDQVKFRFGNQPQVYNDFLDIMKEFKSQSIDTPGVIQRVSNLFRGHPELIVGFNTFLPPGYKIEVQANDQGCYLFQVSVSVPPTASSGASVAPQPSPHKYNTIFQGGGQIATGGPGSGAGGTTVVTASSVGNASGTTGAVNLMAYGGGHAATAAPGASVPIHGGTPLQQPTGGTAGGNASPATAQNAQTLTATTTTTGGASGPQVAQNFSSRSDHHRERTISTGSVASNASLPTGVTASTASSTTVVSAVDATTGGGSAGATVVTGQATPSNIHRILTQQIISQQQQQQGTGAAGAGMVPAGMVTAPTQVQHHQQTTMQQVQPPPEAQTATVTTTVVPTPTATANQPVEFNHAITYVNKIKNRFHTQPEKYKRFLEILHTYQKEQKTYKEGAQSGCMTSAKQLTEAEVYTQVAQLFDNQEDLLREFGQFLPDATSHHNQAAMQQHHLASGKNNSHNLVVNASMHDHQHQQQQQQQQQQQQQQQQQQQPQQQQLGVPAGTAGIVGLGSGASGPAVHGGGGGGKKLGNSNLAGVGSGAGMANLKVYNSMQPANMGRLQQERDFSTMGTDGISIHGSGVGGGMPPGSTISVSSGAIRTAGGNIVGTAAVMLEKDRNHMGGVGSGPGSGGVGGVGGGGMNAKYIHGASIATMNATGAMVGGSVLPPGAGPNVVPSVMANLVSANVGGGGSGGGINAIKRSPSYAAGQIGLVGPGGPAGHGNNMSSSRDRGDGSGPPPIKRHKPICRDVSLAEASKYGTLNDYAFFDKVRKALRSPDVYEDFLRCLTLYNQEIVSKMELQTLVSPFLNRFPDLLKWFQDFLGPSTGVGGGAANDCIPLTAAAAAAARQDRDRTQSELAADVDLSTCKRLGASYCALPKSHEGVKCSGRTNLCRDVLNDTWVSFPTWAEDSTFVTSRKTQYEEFIYRCEDERFELDVVIETNSATIRVLEGVQKKLTRMSQDEVSRFRLDDCLGGTSTTIHQRALRRIYGDKAADIIQGLKKNPSVAVPVVLRRMKAKEEEWREAQKSFNKQWREQNEKYYLKSLDHQGINFKQTDIKALRSKSLFNEIETLFDERHEQNDDAAAVPQASGPHMTIPYKDKTILEDAANLLIHHVKRQTGIQKQEKARIKHILRQFVPDLFFAPRQQLSEDEREEGKNDKDTEMEQDEEVSSAGKSSSSGKKSSSNVPSFSGSNSTSNCNPSSNASGAATSTDTSATSTSVSEGTGKDGEGGNGGASKTVSMSSTSADLQSATSSSTTVTSSGAEASRTKEDGNGSSNTASGNDDSSTDKSTTIKIEIKEESDASMMQDPASASSGTTGQQPMSPPLPPHAVSKHIEEAYTLFFTNNSWYLFLRLHAILCERLRSIYERAQIIAAEERAYESTRNNSTATALRLKPKSEIRIEEYYNIFLDMLKNLLDGNMESSSYEDTLREMFGIHAYIAFTLDRVVQNAVRQLQHCVTERGALECVELFQAEQRRGGAGGLCRTANRRIAAELAYQRKAEAALQDENCFKIYIYKIDCRVTIELLDTESDDTANNFASTQAYGSYVNRLSNPAATGTGSDSGGGGGGGGGGSGGGGGGVGSGGGSVAAANAAASGSSVTGGASGAGGVGNSGGGSGVAETGASVNSSSGSSSGGNNNHNSTPAGTTNSSSSSSSNNSAAGGSTGNAEVKTETPDVELKPQQLVGSTRMPVFLSRNARHSRKHTVGKISVNIEGNPATLKELQAGDAGEEISPNSSKAAKASDANSSSSSFSSSSTSNGSKQQQSHSNVGGAEGEKQRALNESTSEATGATGGKVKFSQQEESGATTGKGETNPSSSPAAAAAAASATRDSCGNGGKAASSGNNNNLNNINNNNSICSTNKQLDNPLWFGGSGVKKAPPPERLPCMNGADRNLLYIDDSEQMKVNRTFKTNQVQKKNFTMYRPGALTRARKSHCRVTTRMNQRFKKVVDTWLDQHVTASQRAMCVDWLLGKRQDLMKNTTSVIVQDNGLSRTPYAPYNRYKVDQIEMMME
The following text describes a protein:
Function:
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved stem-loop structure the association within pRNA.
Sequence:
METQNHLSCTGQTPLTNASGLKLLPQSVEPVYTNSTLTSFSQHGKVLNYDLPVNGLISPSLSNNAHGTLLSNEHITHNSASNNFDYLWKKPKSSVHKDSHVSNQFLVNGSTCPITNGPSIKRSPQETLGNCTSNQTASFNVSSHSVCSPNEANVKMVTAANGAHYGFYEASLPVSVSASNMQSVSGDNLVKERTVEENEAGATEERNHTPELAEALEPSDTQTDLNICEYKESVLDPVIQSTPNPLLPPDVSNLDDPSQLPSQLGDSHLLNEDSLEPFGADLIQDPISSTMYDLEELEVGSTKQKDPQLDTSSLDCPTYSLSAAFPLVAEDTNDSSVLFNASSASPVLGDSVMQESASEMGEDPEGSKAEEPVSGPENVSQDEMTIENTSPEPCVAAEHEEEELEPGEVKGTISRRRIATPEQVCFPLQHGWRREVRIKKGSHRWQGETWYYAPCGKRMKQFPEVIKYLSKNAGPFVRREHFSFSPRMPVGDFYEERNTAEGLQWVLLNSEEIPSRIIAITGKRGRPRNLEKAKAKEQKAKRGRGRPPKVKMIDLLSKADAKLLRKLENQDILSDSEKVQLCKLKKKMRRKARNQEAKLEAAKKLKEIKEKEEKKQKIQKAKNQEKAKNQEKKRTRRQPKQKAPVVQKPDRKLLAQQRRLEERKRQQFILEELKKPTEDMCLPDHQQLPDFPCVPGLFLPSCAFSDCLTTVEFLHSYGKVLGLDEAKDIPSLCTLQEGLFNVGDSLGEVQDLLVKLLQAAMINPGLPPYCQSLKILGEKVSEIVLSRENVSEPLRIFLEAYGGDIELCDSLRSHPFQAHAPHIKTAILAFIVNELNASSLIISEIDKTLENMSHYRKHKWIIEGKIRRLKFALSKRKSSEESQITTTEVSLRRRSERNAEENDELDSIDESAIQKDYVQEEVDIPPSTSVVELERQIEKLTKRQMFFRKKILGSSQRLRTVCLGQDRYRRCYWMLPHLGGIFIEGLPESAEPTEEAALGNDIEASSVKTEDKSFGSLCKTSGHPRNSTAEPEQNSTSCHCSDSKDKEPSGVTDQFPNSVPLTNNQQDLSQSVFLSWLTKNQTSIMDSTVLTPESSPPHSESTPIISSEATEKPEQWLPLISRTPCRNHNQGLSTHSSNRLSPPSPTAATSVKQVNEFTEEAQTFATSLPSNSTPCHVCYNSGKSSTASHEITLTSNILHDSEKEKRRGRRPSKLLKQIEQKYYNQLIERPIPAGVRQKWWWIKDPAMLESLLKALHPRGIREKTLHKHLTKHLQHLKEMCARPASDALFKFTPVDGHRVSQETLDRWSVTDLTFQVDLSALQWVEDLEQRVMLSDLQQRGWSPSAPDSVRTDLKYYEHQLEPADDITVKVKREDCRLYRESSNPLDLAVLRILCLEENVERKYLKEPLWLFSEVQHEKVVITNPEDPLSTTEIEYSITSRLRLWRQTVERCRSAAQLSLCLQQLERSIAWERSLNKVTCLYCRKGDNDELLLLCDSCDRGCHTYCHRPRMNEIPEGDWFCPTCISLQSESEFLRSSGSSKRIRKCTVRFTEDSPSKPSRRREHPTASQFSPGESPASKKRRMGTRSQSPDLTFCEIILMELESHEDAWPFLEPVNPRLVPGYRKIIKNPMDFSTMRHKLLNGNYSRCEEFAEDAELIFSNCQLFNEDESDVGKAGLILKKFYDARWEEFSQERNQISL
The following text describes a protein:
Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEETQIDELYFSLMRIFCSQTLRAAGIDRTKVSLLNSFTDITIRYIRLLSETAMAKAEVGRRSCCDLGDLRLAMEEIGLLNGSEEDVKTLVEWFNGPQVAELRRVSGFVQDSETQVKPKDWLTSLIQKQIRVSGPERFYETVFSASNEEEDVKDS
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MASVWVPAVLTVVLLLLGGSYSSTGGPWCYNEAHCGPNTWLSIGHCGGKRQSPINILSHDSILNSKLGAVNLTGYEDRKKLLEIKNTGKTVDVELEDGLSLSGHGLPSSYTAKSFHLHWGDGVSKPGSEHTIDSKRYSMELHIVHTKNNMNVSDAVKDPEGIAVLGFFLEGSEKAKSKGKTAEAWEEFIKNLHKVSEKDKDEDLTSTISLLDLLGTTNLTSYYRYLGSLTTPQCNEAVIWTIFTDPILVPPKVVEAFPSELRSSDSSSGPPIKNNFRPLQKIGDRKVERSAGLGSAASFLSQSATLLLFLSITSLAASFPV
The following text describes a protein:
Function:
Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids (By similarity).
Subcellular Localization:
Secreted. Note=Secreted into hemolymph.
Sequence:
DDKCSIGCKGSATAPTFLNGH
The following text describes a protein:
Function:
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
Subcellular Localization:
Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.
Domain:
The RING domain is essential for ubiquitin E3 ligase activity.
Sequence:
MDPAVLMEAIVEEVNCPICMTFLREPVSISCGHTFCHSCLSGLWKLPGESQNLSYTCPLCRAPVKPRKLRPNWQLASVVDKVRLLGFCMEMGLKTDVCDLHKEQLTMFCKEDDMVTCEACKQSPEHEAHSVVPIKDVAWEYKWKLQQALEHLRKEQEEAWKLEVSEKEQAAIWKTQMERRKQSIRWEFEKYRQLLKEKELPCQQAEEEAAAAQASLEQEKGETASKLELRREAIIRQSQVLWSMIVELEERSQRPVRWMLQGIQEALNRSESWTLQQLEPISLELKTDCRVLGLRETLKTFAVDVRLDPDTAYSRLVVSKDRKSVHYGVTQQNLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCVENVDRKEVVYLSPRYGFWVIRLRKGTEYRAGTDEYPLLPLTVPPHRVGIFLDYEAHDISFYNVTDGASHIFTFPCYPFPGRLLPYFSPCYSIDTNNTTPLTICTLGGEG
The following text describes a protein:
Function:
Antimicrobial peptide.
Subcellular Localization:
Secreted.
Sequence:
GLMSTLKGAATNAAVTLLNKLQCKLTGTC
The following text describes a protein:
Function:
Involved in the biosynthesis of Glycyrrhetinic acid (GA), a natural product which exhibits anti-inflammatory activity. Involved in the biosynthesis of the triterpenoid saponin glycyrrhizin. Catalyzes three sequential oxidation steps at C-30 of 11-oxo-beta-amyrin. Also able to catalyze C-30 monohydroxylation of beta-amyrin to produce 30-hydroxy-beta-amyrin. May be also responsible for the oxidation at positions C-22 and C-29 in addition to C-30.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MDASSTPGAIWVVLTVILAAIPIWVCHMVNTLWLRPKRLERHLRAQGLHGDPYKLSLDNSKQTYMLKLQQEAQSKSIGLSKDDAAPRIFSLAHQTVHKYGKNSFAWEGTAPKVIITDPEQIKEVFNKIQDFPKPKLNPIAKYISIGLVQYEGDKWAKHRKIINPAFHLEKLKGMLPAFSHSCHEMISKWKGLLSSDGTCEVDVWPFLQNLTCDVISRTAFGSSYAEGAKIFELLKRQGYALMTARYARIPLWWLLPSTTKRRMKEIERGIRDSLEGIIRKREKALKSGKSTDDDLLGILLQSNHIENKGDENSKSAGMTTQEVMEECKLFYLAGQETTAALLAWTMVLLGKHPEWQARARQEVLQVFGNQNPNFEGLGRLKIVTMILYEVLRLYPPGIYLTRALRKDLKLGNLLLPAGVQVSVPILLIHHDEGIWGNDAKEFNPERFAEGIAKATKGQVCYFPFGWGPRICVGQNFALLEAKIVLSLLLQNFSFELSPTYAHVPTTVLTLQPKHGAPIILHKL
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MKENKAFTHLHLHTEYSLLDGANKIKILAKRVKELGMKSVSVTDHGNMFGAIDFYTSMKKEGIKPIIGMEAYIHNDDNLSSKETKQRFHLCLFAKNQEGYENLMFLSSMAYLEGFYYFPRINKKLLKEHSKGIIASSACLQGEVNYHLNTNNERNRKYGAKGYDEAKKIACEYQEIFEDDFYLEIMRHGILDQRFIDEQVIKMSLETGLKIIATNDTHYTMPNDAKAQEVAMCVAMGKTLNDKGRLKHSVHEFYIKSPEEMAKLFADIPEALENTQEIADKCVLEIDLKDDKKNPPTPPSFKFTKAYAQNEGLNFEDDASYFAYKAREGLKERLVLVPKEKHDQYKERLEKEIEVITNMKFPGYMLIVWDFIRYAKEMGIPVGPGRGSAAGSLVAFALKITDIDPLKYDLLFERFLNPERISMPDIDTDFCQRRRKEIIEYMIEKYGKYNVAQVITFNKMLAKGVIRDVARVLDMPYKEADDFAKLIPNRLGITLKGYEKNGEFIEGAWELEPKIKELVESNELAKQVWEYSLNLENLNRNAGVHAAALVVDSQKELWHKTPLFASEKTGGIVTQYSMKYLEPVDLIKFDFLGLKTLTVIDDALKIIKTQHKISVDFLSLDMDDPKVYKTIQSGDTVGIFQIESGMFQGLNKRLRPSSFEDIIAIIALGRPGPMESGMVDDFVNRKHGVEPIAYAFKELEPILKPTYGTIVYQEQVMQIVQTIGGFSLGEADLIRRAMGKKDAQIMADNKAKFVEGAKNLGHDGQKAANLWDLIVKFAGYGFNKSHSAAYAMITFQTAYLKTYYKHEFMAAMLTSESNKIESVARYIDEVRALEIEVMPPHINSSMQDFSVAEFKNQKGELEKKIVFGLGAIKGVGGEPIKNIIEERAKGDYKSLEDFISRVDFSKLTKKSLEPLVKSGSLDNLGYTRKTMLANLDLICDAGRAKDKANEMMQGGNSLFGAMEGGTKEQVVLDMIDLGEHDAKTLLECEYETLGIHVSGNPLDEFKEEIKGFKNLVKSIDIEELEIGSQAYLLGKIMEVKKKIGKRSGKPYGIADILDRYGKFELMLFEKQLNALEELDINKPLVFKCKIEEQEEVVRLRLFEILDLESAREVKIPKARYKDPEKQKEEVREIPPMEMLASSSCSLAIVLENDVKKEFLRQIKESALKHQGKRPLYLIIKDKDKQFKIQSDLMVNEKIKDDFKGLEWRDLA
The following text describes a protein:
Function:
Exo-beta-1,3-glucanase that specifically hydrolyzes laminarin and laminarioligosaccharides, producing glucose and laminaribiose as end products.
Subcellular Localization:
Secreted.
Sequence:
MHVPPTDPARSAPPASPHRRRRPKALGLTALAAAMLMAVPTTQAAFGSDVRPAAAQEVVGGGDLGPNVLVFDPSTPDIQGKVDEVFRKQESNQFGTDRYALMFKPGTYNDINAQIGFYTSIAGLGLNPDDTTFNGDVTVDAGWFDGNATQNFWRSAENLALNPVNGTNRWAVSQAAPFRRMHVKGGLNLAPDGYGWASGGYIADSKIDGEVGPYSQQQWYTRDSSVGGWGNGVWNMTFSGVEGAPAQSFPEPPYTTLETTPVSREKPFLYLDGDDYKVFVPAKRTNARGTSWGNGTPEGESLPLDQFYVVKPGATAETINAAVDQGLHLLFTPGVYHVDQPIEIDRANTVALGLGLATIIPDNGVTALKVGDVDGVKVAGLLVDAGPVNSETLVEVGSDGASGDHAANPTSLQDVFVRIGGAGPGKATTSIVVNSNDTIIDHTWVWRADHGEGVGWETNRADYGVHVKGDNVLATGLFVEHFNKYDVQWSGENGKTIFYQNEKAYDAPDQAAIQNGDIKGYAAYKVDDSVTTHEGWGMGSYCYFNVNPDIRQQHGFQAPVKPGVKFHDLLVVSLGGKGQYEHVINDIGDPTSGDTTIPSQVVSFP
The following text describes a protein:
Function:
Peroxidase which is involved in maintaining the cuticle integrity in the hypodermis and pharynx. It thus plays a role in conferring resistance against Gram-positive bacteria such as E.faecalis, S.aureus and C.diphtheriae, and yeast such as C.albicans.
Subcellular Localization:
Secreted.
Sequence:
MNLKPTILLFTILFLKCATFEVNEETERIVEDAVMRALDSRASENSESEQTSQHIIVSQQANSDSKSAQFTGEVLEEATRILVREFGLEILPAANEVIERWRNEEEELLQSSETTTTTEHPDPTRSKRSAIFRSKRQANRRCSSPPINCNNRFHTSIRSITGLCNNRQNSDLGNSVSPLRRILGAASYADGLGRIRTRSVNGGELPSARLISNRIHDDRNNQVFSPSINHLHMIIGQFIAHDVVFMPSSVARDGGALDCSACNSPQRVSPNCAPITIPRNDPYFNTPCMRLTRALNGQENFGVRSQIGQNSHFLDLSPVYGSADCEAETVRSFQEGKMLTFDDLGYTLPPQNANDSNCQSSAPFHCFTCGDFRNSLHPALIPVHTILIKEHNRLAEQVRVARPRFNDEQIFQLVRKIMIGMWQHIVYNEYIPKYLPRRTIRNFALRPLRNGVHRGYSTSVDPSISAEFAGAAFRFGHSQSRFDFPRLTENGRPAGNYDLGNDIFYADQMYLTRIGGWEPVMNGMVRMPAMKSDRYFSFGIRNQMFEIRGRNGSGVDLVSINIQRGRDMGLFPYIQYRQLVGLPTVTSFNELNTTFSQENIQALRNVYSDPADIDLYVGIMLEEPLSGGQLGPTASFMIGEQFRALKRGDRFFYESIAEGTDNFTQEEISELRNKTSLAKIICTNMDFAARINTDIFDHRSRQVACTSLPQLDIDRFLR