lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.
Sequence:
MTLGIFANCIFCLKVKYLPRQQKKKLQTDIKENGGKFSFLLNPQCTHVIVDSADVLSRCHLNSIQKNDVQIANPAFIQDSVRQRRLLDVRNYDPLSPAPAAPPAERSRSEVQSEYLPSDNTPEKENTEVTEVSAENVEIPPFLQDFEVVKYNILEKVGGPETVVVELQSSQDPESCPFVITAHFLLADQKTRRESTGKQTSEGAIEYYESYVEDLKRQGFLLQEHFTAEATQLASEKLQALLLEEVISSGALSQEVSDLLEVIWTEALGHLENTLLKPVNSMSLNDVSKAEGILLLVKTALKNGDSPGQLQKTMAEFYRLLPHRHPASEEVNLRLLAQKEDLCQLVRDMVNVCETNLSKPNPPSLAKYRALRCKIEHVDQNTEEFSRVRKEVLQNNRSEQPVDILQIFRVGRVNEATEFLSKLGNVRLLFHGSPVRNILGILSRGLLLPKVAEDRGVQRTDVGNLGSGIYFSDSLSTSIKYAHAGETDGSRLLVVCDVALGKCVNLFKKDFSLTEAPPGYDSVHGVSETTSVPTDFQDDEFVVYKTNQVKMKYIVKFCTPGDQIKEFHPHENTEVEEQRAEPSSVPEAGDFQLPDIKPFTNIKAGLQDASANPVPLDSVHIKGRVIDFVAQVIVFQTYTNQSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIVGEIKEKEEARQEYREAVSQGHGAYLMDQDTPDVFTVSVGNLPPRAKVLIKITYITELSIQSPVAIFFIPGTVAPWQQDKALNENLQDTVETIRIKEIGAEQSFSLAMSIEMPYMIEFISSDTHELRQKSTDCKAVVSTVEGSSLDSGGFSLHIGLRDAYLPRMWVEKHPEKESEACMLVFQPELADVLPDLRGKNEVIICLDCSSSMEGVTFTQAKQVALYALSLLGEEQKVNIMQFGTGYKELFSYPKCITDSKMATEFIMSAAPSMGNTDFWKVLRYLSLLYPSEGFRNILLISDGHLQSESLTLQLVKRNIQHTRVFTCAVGSTANRHILRTLSQCGAGVFEYFNSKSKHSWKKQIEAQMTRIRSPSCHSVSVKWQQLSRDAPEPLQAPAWVPSLFHNDRLLVYGFIPHCTQATLQAFIQEKEFCTMVSTTELQKTTGTMIHKLAARALIRDYEDGILHDDETNHEMKKNIMKSLIIELSKENSLITQFTSFVAVEKRDVNEIPFANVPNISELVAKEDVDFLPYVSWQEKQPEASISQTEIDSSRLKHNKLSDGHGVLQPVSVSSEVNEKPSLLLAAKKRKIKTIKKCSLDISEDFEDRTAVAQSPATAQSLNFHLPLSVRPQLKAVEQQLHGNRLEPKQRGGFRKLLMAKKCRNVPDSLVSSAPAVTAEFSYLSACSSSSAFLSPLCDIPSSLPPHPLGGTHPPPPLPLPDGTHLPSPLFGSTHPPPPLFGGTLIPPPSSLFGGTHLPPPPPLPGGTHIPPPPPIPGGTLIPPSSSLFGGTHLPPPPLLSAGTHIPPPPLLSAGTHLPPPPLLPAGTHIPPPPPITGSTHPPPPSSLFGGTHLPPPPPLPGGTHIPPPPPIPGGTLIPSPSSLFGGTHLPPPPLLPAGTHIPPPPPITGSTHPPPPSSLFGGTHLPPPPPAGTQFSLSPIGFIPPKLGPPKLSHSHKLVGDTNIHDSEPPLLGFKDLCSRDMGFSCGTAFSGSFASSKDFDPGKFSQGPNNISFSPKAPEMGVLHQSPFCSPPKPPSAPPLVTNVLCSEAPQSYFLNLQSAAVHQSPNNRVSEIIMESVESSLPSDYSSRDASSYLALEGAEDSLLGGSSFETDTDEAAAFIANDLLTSIETSSDEECAFCDEDQESPVPWASLFALQTENGFWKLTPELGLILNLNVNALLTSLEEKGIRSLGTKGRERLLDLIATLLVLQFLYTKLEQEGMVAKSLIKMDDAFISRNIPWAFENIKKAREWARKTEGQYPSICQRLELGKDWESATKQLLGIQPQANTSLHRILYYSQG
The following text describes a protein:
Function:
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Subcellular Localization:
Cytoplasm.
Sequence:
MRLYLIIESGKSTKLRRKEMNIEYRGVDVNISEAMKAVIESKLNRFKRYLKEVGEDEVEAVVAISSTRSRQKDYAGDSLPTFYRVDLHLYLKNVPHGAIHAWEEDTDVFTAIDKALDELEKQLVKLKERRHEYIREARKFKEKLHEAELAPEERERPEIVEEELVVDKPMSVEDAKAELEETHAYFIPFVDIADGQLKILYRKRGGNYGLLSTGCKYL
The following text describes a protein:
Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Miscellaneous:
MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.
Sequence:
MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNXERSVYLSAFFVLCFMFLDSSSLWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNINEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
The following text describes a protein:
Function:
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Subcellular Localization:
Nucleus.
Sequence:
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
The following text describes a protein:
Function:
May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction.
Subcellular Localization:
Secreted. Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit.
Sequence:
MTRRGCWPHRIIFSLILLTWTHVTLAALIRSHTFSNWPKPPCKMYYPIDPDYEANCPDVIALVCATNGLNYKNECFFCIDRWEFGPHIEFVKYGKCE
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MDDDNGLELSLGLSLGGSSGKAKARDAPLEPKAEPQVEESSSKGGSQTPDAPFGKFYQKSAENQEQNSKQRHSPVAQQFGNFWGQPGSSSGPVVDGSIEPVSHQPQLSSYQDGRMPNNSGNNSEEQKPVSSNRKLSEEMNFQKKHQTASDQPDAFSKSSDGGAKNAPISISTDDGSTGENEDVAESEAEGSNSWLVAQREDSAKGSVVNKGSDRKRSADDAAVGFQGKRQPSFSGSESSSGKLTPGNPLSMQASNAVAVPYQVPAQVSGPPTITNAPNFHPVCTVQLRPPTNGGLTVQTMGNASQVAFGYPAVQLPTLETSSSWAFGAPPQAVSSFTAKEQTGTKQADDGKKPQEAGASSSAHAEDEKKADRGLSLMGSAIRPGIAPNVKFGGSGSYPDLPWVSTNGAGPNGRTISGVTYKFGRNEVKIVCACHGTHMSPEEFMRHASADAPAQENSATLPAFPVGNQATSAEN
The following text describes a protein:
Function:
High-affinity Na(+)-coupled choline transmembrane symporter. Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry. Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion. Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release. SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials. Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity.
Subcellular Localization:
Presynaptic cell membrane; Multi-pass membrane protein.
Sequence:
MAIHVEGLVAIILFYLLILFVGIWAAWKNKNSGMAGGIDRSESIMVGGRDIGLFVGGFTMTATWVGGGYINGTAEYVYLPGYGLAWAQAPFGYALSLVVGGLFFAKPMRSKGYVTMLDPFQQMYGKRMGGLLFIPALMGEIFWSAAILSALGATLSVIVDININMSVIISALIAIFYTLVGGLYSVAYTDVVQLFCIFLGLWVSVPFAMLNPAVKDIGITAVTDVYQDPWLGTINPSDIWMWLDNFCLLMLGGIPWQVYFQRVLSASSATYAQVLSFLAAFGCLVMAVPSVLIGAIGASTDWNQTTYGSLQPMQKEESDMILPIVLQHLCPPYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLAFRQTASDREIVWVMRITIFVFGALATAMALLTGTVYGLWYLSSDLVYVIIFPQLISVLFVKGTNTYGSVAGYVFGLILRISGGEPYLRLPPFIYYPGWYTQVKEHPLTGEIEQLIVQKFPFKTMSMLSSFLGNVVFSYLMKYLFESGTLSPKYDFLEAVVARHSKENMDKTTLVNSDNIVLSELASVNPRLSTTLAGTFTNKEALSDEDTSPETSNNENDE
The following text describes a protein:
Function:
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Domain:
The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.
Sequence:
MPLVPALWVAKAGHCSSSGVEDQPGQRGETLSLQKKKKKKNSLAWWYVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRVEMGFHRVSQDGLDLLTFAGITGVSHRVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD
The following text describes a protein:
Function:
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.
Subcellular Localization:
Cytoplasm, cytosol. Lysosome membrane.
Sequence:
MAANFRKAYYSSLGVKTLEVKPSVENALQGKLLSIDRLNKLCLWIRIPHFYRPVVWKLLLGVTPVHKEAWGFVAEQRQQHFEILKESVLLLTRQSLDRIDEDLTPLLLAQMIQLELIQDTPRTISQTITNEEPPEHLLAISAAFLEISDSSDQDAFWICLHFIKKMHIDISKSPKSGSQYLKTAFIGNNPVADLIAKSAAVYPGPEQPLLVSADQPFINDIRSSIDTMKYLLSLHNLQLFTYIQRLNVAWHDVCSCWFRCCFANVISSHAIESVWDIVIGGAPGILPYLGLCLLLSARRKIEACRSAKEFAALIPQISKFVDVDSVANMSIDMWEIPVLERMSKETRKLLGYRF
The following text describes a protein:
Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA).
Miscellaneous:
MISCELLANEOUS: Present with 1600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL
The following text describes a protein:
Function:
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MATLSLLSTGVGAAITNRTPSASLTFITGSRTTNKRVSFNGGSARSGSLHCSFLAPSSSLSSNFSGLSLGLDLTSNTGVSTDRCRRFVVRAGKAALCLTKRSRSRKSLARTHGFRLRMSTTSGRALLKRRRAKGRKILCTKTNPSSGKRASP
The following text describes a protein:
Function:
Member of the two-component regulatory system CrdR/CrdS that induces the transcriptional induction of the copper resistance determinant CrdA. Upon phosphorylation by CrdS, functions as a transcriptional regulator by direct binding to promoter regions of target genes including the crdA promoter or nitric oxide-responsive gene promoters.
Sequence:
MQKKIFLLEDDYLLSESVKEFLEHLGYEVFCAFNGKEAYERLSVERFNLLLLDVQVPEMNSLELFKRIKNDFLISTPVIFITALQDNATLKNAFNLGASDYLKKPFDLDELEARIKRFFNDDPIEIMPNIFYHQNCLSVRGKKEILPPKTAQLLEYFLEHKGQIISSQALENNLWEQAIDDSTLRTYIKVLRKLLGKNCIETHKGVGYRFNPL
The following text describes a protein:
Function:
Specific inhibitor of cysteine proteinases. Probably involved in the regulation of endogenous processes and in defense against pests and pathogens (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MLRRRGFCCCSGAPAAAAAALLLLAVAAAAPRAAGFHLGGDESVLVRGMLAAIRREQAEAEDAARFAVAEYNKNQGAELEFARIVKAKRQVVTGTLHDLMLEVVDSGKKSLYSAKVWVKPWLDFKAVVEFRHVGDSQSQSATAADDNAGQDTADPTVASRNDLHNTENNKVSVVLSTFSQTYSV
The following text describes a protein:
Function:
Catalyzes the depolymerization of both polygalacturonate and pectins with low (20-34%) and high (90%) levels of methyl esterification, with an endo mode of action. In contrast to the majority of pectate lyases, displays high activity on highly methylated pectins. Does not show xylanase and cellulase activity.
Subcellular Localization:
Secreted.
Sequence:
MKKMLTLLLSAGLVASIFGVMPAAAAPTVVNSTIVVPKGTTYDGQGKTFVANPSTLGDGSQAENQKPVFRLEAGATLKNVIIGAPAADGVHCYGNCNISNVVWQDVGEDALTLKSSGTVNITGGAAYKAYDKVFQINAAGTINIKNFRADDIGKLVRQNGGTTFTVNMTLDNSNISNVKDAIMRTDSSSSQGRITNTRYSKVPTLFKGFASGKTSQSGNTQY
The following text describes a protein:
Function:
Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.
Subcellular Localization:
Nucleus.
Sequence:
PVLQFHNTRGEHVRLSADRSTARRVDSFCKGIAFSQRTVRPNEKVYLRVAECSTSWNGVLRIGFTSCNPASFSGVLPKYACPDLTSRPGFWGKALPERYVESGVLFSFHFTASGDVMLNVNGQDKGVFLTGVDARTPLWIMVDIYGNTTAVQFADLLVSMNALNLNRGPHQIPSLPLPPIPGSMAGHHHLQQQQLQTNNTIQPPAPPAVLQNFPPPPPLRHYRHHSFQPLTFHPRTHGINIRMGSDCRTAVRHDAEFCNGYVLSSRPISPGESWVVQIVQTESIYVGGMGFGFTTCNPASLSSTDLPDDADQLLDRPEYWVISKDVAHGPILGDEIEFHLSHSGEVTMMRNRGSATLLMHVDVSLPLWAIFDVYGSTRAVRLLGTISPPQSVPEPPAVIYQAPPRMSPPRPQQQQQQPIYQSIGSATHMMQPTIPAGVLSSGTASSYVETLTQSLNCQTASGGASSECTVCYERSVDCVLYSCGHMCLCYDCALTLYHGGRTAGGQGLCPICRAPIRDVIRAYRS
The following text describes a protein:
Function:
Forms the helical nucleocapsid (NC) in a ratio of 1 N per 6 ribonucleotides, protecting the genome from nucleases. The encapsidated genomic RNA serves as template for transcription and replication; encapsidation by N is coupled to RNA synthesis. Forms the encapsidation complex with the phosphoprotein protein P. Before encapsidation, the newly synthesized free N protein, so-called N0, is chaperoned by P (By similarity).
Miscellaneous:
MISCELLANEOUS: Most abundant protein in the virion. Since the viral RNA genome consists of 15,383 bases,there are 2564 molecules per encapsidated genome.
Subcellular Localization:
Virion. Host cytoplasm.
Domain:
Ncore is globular and carries regions required for self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain in the C-terminus.
Sequence:
MAGLLSTFDTFSSRRSESINKSGGGAVIPGQKSTVSVFVLGPSVTDDADKLFIATTFLAHSLNTDKQHSQRGGFLVSLLAMAYSSPELYLTTNGVNADVKYVIYNIEKDPKRTKTDRFIVKTRDMEYERTTEWLFGPMVNKSPLFQGQRDAADPDTLLQTYGYPACLGA
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose. Is Required for swarming motility.
Sequence:
MPVRAQRIQHVMQDTIINFYSTSDDYGDFSNFAAWPIKVDGKTWPTSEHYFQAQKFLDEKYREEIRRVSSPMVAARMGRDRSKPLRKNWESVKEQVMRKALRAKFEQHAELRALLLATAPAKLVEHTENDAYWGDGGHGKGKNRLGYLLMELREQLAIEK
The following text describes a protein:
Function:
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.
Subcellular Localization:
Nucleus lamina.
Sequence:
MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSMSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEMAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM
The following text describes a protein:
Function:
Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro.
Subcellular Localization:
Cytoplasm. Mitochondrion.
Sequence:
MTSKLKRVAVAQLCSSADLTKNLKVVKELISEAIQKKADVVFLPEASDYLSQNPLHSRYLAQKSPKFIRQLQSSITDLVRDNSRNIDVSIGVHLPPSEQDLLEGNDRVRNVLLYIDHEGKILQEYQKLHLFDVDVPNGPILKESKSVQPGKAIPDIIESPLGKLGSAICYDIRFPEFSLKLRSMGAEILCFPSAFTIKTGEAHWELLGRARAVDTQCYVLMPGQVGMHDLSDPEWEKQSHMSALEKSSRRESWGHSMVIDPWGKIIAHADPSTVGPQLILADLDRELLQEIRNKMPLWNQRRDDLFH
The following text describes a protein:
Function:
Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
Subcellular Localization:
Nucleus.
Domain:
Contains at least 4 autonomous repression domains (RD1-4); Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors; The Ligand-dependent nuclear receptor binding region is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB.
Sequence:
MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAINKKSAGHKEEDQNFNLSGSAFPSCQSNGPTVSTQTYQGSGMLHLKKARLLQSSEDWNAAKRKRLSDSIVNLNVKKEALLAGMVDSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHESLKVEKDLRCYGVASSHLKTLLKKSKTKDQKSGPTLPDVTPNLIRDSFVESSHPAVGQSGTKVMSEPLSCAARLQAVASMVEKRASPAASPKPSVACSQLALLLSSEAHLQQYSREHALKTQNAHQVASERLAAMARLQENGQKDVGSSQLSKGVSGHLNGQARALPASKLVANKNNAATFQSPMGVVPSSPKNTSYKNSLERNNLKQAANNSLLLHLLKSQTIPTPMNGHSQNERASSFESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRIEKPEAERPVSLENLTQSLLNTWDPKIPGVDIKEDQDTSTNSKLNSHQKVTLLQLLLGHKSEETVERNASPQDIHSDGTKFSPQNYTRTSVIESPSTNRTTPVSTPPLYTASQAESPINLSQHSLVIKWNSPPYACSTPASKLTNTAPSHLMDLTKGKESQAEKPAPSEGAQNSATFSASKLLQNLAQCGLQSSGPGEEQRPCKQLLSGNPDKPLGLIDRLNSPLLSNKTNAAEESKAFSSQPAGPEPGLPGCEIENLLERRTVLQLLLGNSSKGKNEKKEKTPARDEAPQEHSERAANEQILMVKIKSEPCDDFQTHNTNLPLNHDAKSAPFLGVTPAIHRSTAALPVSEDFKSEPASPQDFSFSKNGLLSRLLRQNQESYPADEQDKSHRNSELPTLESKNICMVPKKRKLYTEPLENPFKKMKNTAVDTANHHSGPEVLYGSLLHQEELKFSRNELDYKYPAGHSSASDGDHRSWARESKSFNVLKQLLLSENCVRDLSPHRSDSVPDTKKKGHKNNAPGSKPEFGISSLNGLMYSSPQPGSCVTDHRTFSYPGMVKTPLSPPFPEHLGCVGSRPEPGLLNGCSVPGEKGPIKWVIADMDKNEYEKDSPRLTKTNPILYYMLQKGGGNSVTTQETQDKDIWREPASAESLSQVTVKEELLPAAETKASFFNLRSPYNSHMGNNASRPHSTNGEVYGLLGNALTIKKESE
The following text describes a protein:
Function:
N-acetylglutamate synthase involved in arginine biosynthesis.
Subcellular Localization:
Mitochondrion.
Sequence:
MKPPIRPQVTLRSLKRTPNPTPVVCHVRQRHHESKILQEIKDEDNAFILSILQASPSARDSRSYLSSFAPPQPADIATATPAATPSDGAQPPAQNPLVNALLNPILRRPALVKIQGPFTDAQLESICRGMAHLQKLGLVSVIVVDRDDLPSTESSDRYEAQRQRAIVRHEVERVVHFLSRHRAAARPVFSTVARIADPELEPEEAQKGVFVEEEGLDHVRRAVGEGEIPVLLPVALDSGCRSRRIPANRVLLALASAMSTHTSSPVDLTPRRLLVINREGGIPSYARQGLPHLYINLASEFSYINRTFQPQWNDSHPTALSNLFLANGCLAHMPREASALIVSHRSPAALIANLITNKPAHSASLPHALLVESEGRITRDTPTLIRKGLPVRVLRSMEEVDQDKLTHLLETSFKRTLDREGFYNRLKNDLDFVIVIGDYAGAAVCTLEGKPVSDSFAYPPNHPEPICYLDKFAVHPSHQGDGTVDFLWVALRDETYGLGQLDASNPSIGSLRGVGRGRDLVWRSRSDNPVNKWYYERSSGFLKTRDEKWKVFWCDAEQRLGEIWREREFGGGRLVRVVEKEEKGRVKWWEEVIGAIPSAWSA
The following text describes a protein:
Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MVSNASALGRNGVHDWLLLRASAIVITLYVFYILGFVVIVPDITYEIWRGFFASHITKVFTLLTLLSILAHAWIGLWQVLTDYIKPLAIRLVLQLVVVITLLVYLLYGTIVVWGA
The following text describes a protein:
Function:
A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Cell projection, rhabdomere membrane; Multi-pass membrane protein. Note=In the dark, there is 20 fold more rhabdomeral trpl protein forming plasma membrane channels than in the light. In the light, the protein translocates to an intracellular compartment. Protein levels remain unchanged in light and dark conditions.
Domain:
Binding of calmodulin to binding site 1 is Ca(2+) dependent, whereas binding of calmodulin to site 2 is Ca(2+) independent.
Sequence:
MGRKKKLPTGVSSGVSHASSAPKSVGGCCVPLGLPQPLLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKVDINTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYDPQMSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQATEIARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVIRIFRKSSKTIDRQRSKKRKEQEQFSEYDNIMRSLVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEMLEIFENSGMDVSSANKKERQPRPRRIKVWERRLMKGFQVAPVQNGCELDAFGNVNGQGEMQEIKVESIPSKPAKETAKERFQRVARTVLLQSTTHKWNVVLRAAKDSQIGRCTKNERKSLQNLGRAIEEAKRLIMLNPGCPSGRESPIRIEFEDEKTSTLLELLNQISAEISDSEKPKIRPIWRPPLKTVPARAMAANNTRSLTAPELKISRKSSPAPTPTPTPGVSHTALSQFRNRELPLCPSKLIANSAPSAPTAPPKKSAPTAPTPTYKPTTHAPFSVEGGNRENTRASDGVRSDNSNFDIHVVDLDEKGGHLGRDNVSDISSIASTSPQRPKHRN
The following text describes a protein:
Function:
Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1.
Subcellular Localization:
Nucleus.
Sequence:
MQNCGGGPVGGVGSVGTRRAFDSICPNRMLDLSSRQLRKPGKLEKKFAPPRKFFGSSSPISVYTDPPEAELAGLPALTTIDWQDFADCCSLLHQGSSPSCDAAISQNHGPQTEPEFDLQDFRDAVDNLISDPSSLMSSPMGPEDFSFPSCDVSPFGSCISPRPEHPMPPVSIQDVPHPEQYWKEVADQNQKALGDALVENNQLHVTLTQKQEEIASLKERNIQLKELASRTRHLASVLDKLMITQAQDCLAAPEPFLLKASAKRSLEELLTASGQDGAEVDAMLRAISEQCDAALQSRDTKRPRLQPGAPDTDSTPAVPLHGAFRGLQADLPQRSLNLSHSELEDGDSFSTPIRDHSTIRTLAFPQGNAFTIRTASGGYKFRWVPS