lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans.
Miscellaneous:
MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD medium.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRRKNRLFILVVLLGIVLVVYYSQLNSLDLVEPVQSSSSGNGGCWSYYEGLTPGWLNDFYDVNQITPNPAKDVIELVTRIKIFFNCLQQVDGHNIQRLRDIEKKLFPYINFEKLETDESAFWHTTTRWNGEVYHASMLEFDPKNHQFLRSKPINFDTGLSFWENWLHTVTQSGSKGIVISASDVQLNETIRLLKVLRFIKNDYPIQIVHNADLSQDSMKSIIKYARSLDTAEYPAQELWFLNVHSLLNPKYSKKFTTYSNKWLALTFSSFEIPILMDSDTVPFVSIEKFYELEEFQKTGVLFFKDRVISDDLFESSELKILREIVYGCIGLDLEDESKIHEQVEDPVVAQVLENMFIKKYKHHLESGLVILHKGKHLFSMLTSIALQFSPIAEYFHGDKDFFWLGELLSNNRFTFHPVDASNIGQLGNVVSKESTGEFYQICSVQLSHTDRDGSLLWLNGGLNICKKTSWEYDYEHRQRLNDMFQNADELREYYASPVKLEGIIIPDTSISGWINSGECFLFNYCTLFKEGEFGKLIKFKEDEKLRLSQIVDIWNKDI
The following text describes a protein:
Function:
Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MNNKSFNCLLYVFFIITILFLIAPLFLLINRGVVYIIPCLRSEEVLFSIKLSLKTAIISTFICLIFSIPTSYILVRHEFKYKKLISSIIYLPMSLPHIVSGIALLLLFGKSSFGNFLYNKLNLDFIFTVKGIILAQVFVNLSFTIKILATSLEESNTRMEFIARTLGCNEFEAFRYITIPKLKKGTITAIIMTWSRALGEFGAVMMVAGSTRMKTEIIPTSIFLNMSTGDLDTAIGVATILIIISLISIITFEIIDKKKS
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Subcellular Localization:
Cytoplasm.
Sequence:
MDLWFSEVHTPDVKLSLRTAKQLYAGKSEWQDIEVLDTPAFGKILILNGHVLFSDADDFVYNEMTVHVPMAVHPNPKKVLVIGGGDGGVAQVLTLYPELEQIDIVEPDEMLVEVCREYFPDFAAGLDDPRVTIYYQNGLRFLRNCEDDYDIIINDATDPFGHTEGLFTKEFYGNSYRALKEDGIMIYQHGSPFFDEDESACRSMHRKVNQAFPISRVYQAHIPTSPAGYWLFGFASKKYHPVKDFDKEGWKKRQLFTEYYTANLHVGAFMLPKYVEDILEEEEGKK
The following text describes a protein:
Function:
Possible regulator involved in a circadian clock input pathway.
Sequence:
MSNSGEDFQVVTRKKWMARKCLRRRDRHKSESDYLIDCPDVNVEKFQPRLENLCTEMCQSDYFLVAMEALQQQLEGIRKPLERIVCLGLGPFSRTYHALHQAAFVIGLHRHHKIREALYFDPVFRDSEKELIRLFDGCIMSKDCAGKHEATVPTLYYLPHCPYALMHNILWSNWKRETLPNVFLISNSFEMLTMTPRNQDDHITRIVEHCTETPLEDDYEHHNVFNDLSLHTFPQESLPGSNDEAFWTRCAPLKVNEDELITETETSLAALKLESE
The following text describes a protein:
Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MITWSIDSIYVVLLLRTLIPYTCLFLSSLIPPHIPVYDKRMGVIRVFLSWDVEWFLRIAGGGYSTEARLAFFPALPFLLREIGIKGVLALNGVLRIINAVLQIKLCWHLNRLAGEAFTPQTIRKLHFLLIFSPIAVFETVPYTETLFGCLSVMFLLVYSSMTLYNKKVQVLGYVALVLIGMLMGLVRNTAVFHAGYFMFGVIFLSRPIGELILSGYYFLSVLLPLKRRLEQYYEMCIPLKNVSKIYSNIQNKYWGVGLFNYWKITNLPRFLLVLPSTFLCLSYMFTESKKWIHSVCRERNVFPRLTSFKFAVATHAFVLTSIVVFLANVEILPRILLSSCPSILAHVPFNRSTIYMVVLVSTLGAGLFGAFLPWT
The following text describes a protein:
Function:
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Non-canonical donor and acceptor splice sites for the last 2 exons; MISCELLANEOUS: [Isoform 2]: Non-canonical donor and acceptor splice sites for the last 2 exons.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome.
Sequence:
MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPAVGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGIQLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSAELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQSPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKVLEEWKTHLIPSLHCAGGEQKEESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQA
The following text describes a protein:
Function:
Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Subcellular Localization:
Nucleus.
Sequence:
MSSSNNQHSTELRSELYFLIARFLEDGPCQEAAQVLIREVEEKELLPKRVDWTGKEHARTYHNLVKYYRHLAPDHLLEICRRIGPLLEKDVPQSVPGIQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPEPPINYGSPPSIANTFFARKLNGNYQFENLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNFENTMIAAGSCDKMIRIWCLRTCAPLAILQGHSASITSLQFSPLCNGSKRYLSSTGADGTICFWLWDAGTLKINPRPTKYTERPRPGVQMICSSFSPGGMFLATGSSDHVIRVYYFGSGQPEKISELEFHTDKVDSIQFSNTGNRFVSGSRDGTARIWQFKRREWRSILLEMTTRPTGVQGFEDKITKLKVTMVAWDRHDNFVITAVNNMTLKVWNSCTGQLVHILMGHEDEVFVLESHPFDPRVLFSAGHDGNVILWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMYFHSDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCRDEQLIPQMGLTSSGMNQVLSQQANNEASPLDSLIQRLQQEQDQRMNAETSSGSNSRTGRASVSSSSEVHSPPNIGLRRSGQIEGVRQMHRNAPRSEIATERDLVAWSRRVVVPELSTGVLSKQEEWRTAKGEEEIRMYKEEDKRKTITNHAVRENKVSYSKNHSLELLLDNGDSKKQSSTSNNCHTRATLEEQAGPTEEVENSSSDEADVESEAIAASGATSEEGEKREWHSDGSSSDYSSDYSDWTADAGINLQPPKKTLKHRTKRAESSSEDEEKSDKFKQKQKKERKKGMDEKDGPSSPKKRTPKERKQKRLPIGELTEQGLSLEEWLPSAWITDTVPRRCPFVPQMGDEVYYFRQGHEAYVEMAKKNKIYRINPKKQPWHKMQLREQELMKIVGIKYEVGLPTLCCLKLAFLDSDTGKLTGGAFTMNCSIYIPMVPVPPNVREEKMIYWYHDMPDVIDFLVLRQQFDEARRRQWSIGDRFRSVIDDAWWFGTIESQEPLHQDYTDSLFQCYNVCWDNGDTEKMSLWDMELVPDNAVFPEELGTSVPLTEGEVRSLLYRSLDGEWGCRSRDEECDRITAGINQLMTLDIASAFVAPVDLQAYPMYSTAVAYPTDLSTIKQRLENRFYRRLSTLMWEVRYIEHNTRTFNEPESPIVRSGKFVTDVLLHFIKDQCCYDIIPLYNNLKKKLLSDSEEEEEKEADVPGTCTRKRKEYQPRRKLRSTAPSYDLLSWKKQCQELLNLIFQCEDSEPFRQPVDLLEYSDYRDIIDTPMDFGTVRETLEAGNYKTPLELSKDVRLIFSNSKSYTPSKRSKIYSMSLRLSAFFEERMSNILADYRSALRFHKRNTKTKSRRKRNRSSSSSSSAASSPERKRRYIKPQTNSENTTVSPASVHQRTVAHKVPNTLVNGKTTESSALARSRSYRRHIESAVPEQPTTSGTPKQLNVKSNHSTVAAKSAMIENATKLHKNQNASPNQASNHLTKNNVPKGKLEKDKPFKQRMKASSSMALPADRKEILNQVSSIQVNGHSSQPLKPIVKGRPGRKPKVILNNIDKCETNTVDQVVPKKRGRKPKYPRNEGLPSAPQEPQNSVVETGKFKDHPAPSTCNSHEALYNKTENEVPKKRRGRKPKVKTEPGNVAAVTPALSAHELEREETIKIQTRSKCRKSDQPEDESLGESLSEDINNTETQIRTRNQGKRTAFYNEEDSEEEQRQLLFEDTSLTFGTSRRGRVRKLTEKAKANLIGW
The following text describes a protein:
Function:
Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes.
Subcellular Localization:
Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein. Cytoplasm. Note=Localizes transiently to pseudopods and nascent phagosomes during cell corpse engulfment.
Sequence:
MSDDEELQLAIEISKKTFKDEQKLRSNDLDLIRFESPDEPARQRKINQIKQLYEANSPGPSSYSGSLATSPIDFRPVYNEPRAGPIPHSQSYPRNYFQDWSAIASTSQPPAFPPPPRPPKPEQYKFPPAPSVPLLHDRYFVPPPPPVPPRHSRVQQSPPVPIHPTPPVSSTPLRHSAPSFASDSQQFLSPIKPFEISFNSTVDTSSNQTGSHDHSIQYQPLTHLYVPYVMHSLNSSYGALLNGDLIDLSAFEDSSNASQDEIRKEFDPLFISTYSTDTPSPDNSMPAVNAYFSKPIDEPECVGGAKLIQENIEFPSSSFCLIDCPNGIEEQVKKLCKRNLIRKDMTPDFFIAPTVDYMVTTASTVKVVVYKDHSWKANKSNGKAMICAIDEKMDIITTQALSLFDSELPTDKEYGLKIYGLNQFLSSDSLLGSNLYTGHCLLNGDDVKLDLGVFAPNSRIYEQTLESWNLMKSQVKYSTVVDKEDVENTLGHLASEMSQYEIAFNDGSTLKLSSSSQRVKQVIMLLCKCLHGIVPEKLYNEMQKYLASTTEDQLVHHRNDFLREIHSFLELYCRCTVSRYNIPPLQIITKPKVEVLSKMDFLQIMLNSVHSIPEHWQSQYSEFYMSLDLYHGTQVLDGFSNKVPKTIKNDHFFPRIPLDLYAKFKRLNLCQYPRETRIVVSISGTVRNSAQAANEYNPDIVMLGYCSVPLYDENLFMRQGPLFLPLTLLKKQPMLKPFGPYPYIKDARDPILIMSFKIWDTEIYFPNVVIDMQCIPQDFATLDIETQEYLLELIENQDTSTLETDDQDLIWQKRLHLTNQPEALPLVLSSLQDWSFGFVMRVYQILEEWAPLRPEIAMEFLLPKYPDERIRAHAVQSLARGSTDFLYHTIPQFIEALRFELYEKSALADFILELSFVSLDFTFEIYWQLQQRVDHCAVDDLPYAIRCQNLQQKMIDEHENPNLKTDIKLQHELLNELDSIQDDLRSKSGDSEIERLHRLRTRLGILDSKLLQNKVRLPICPAFDCTGVRIEECSVFNSNAKPLKIVFRGLNMNYSIIHKRDDDMRQDAFVMKMLNEMDRIWKSNGLDLRMITFRIMPVGYRRGMGELVLNCATLMEIQKEEGLRGVLNDEILRKWLMKHNSDEFAYKEAQENFIRSCAGWCIVTYVLGIGDRHNDNILFTKNGHVFHIDFGKYMGDWQMAAGFRRDRVPFVFTTEMFHVINNGRAPTQYNQKFIDYCCKAFNHLRRNKNTLTNLLRIMACSDIPGINMDSLAFVENNLMLDLSDTDATVQFTAMIQNSLGSAFVRLNFVAHTVAQFISSRPSFSKQDPNKLSFVPELYTENSDGRISRVTVLKFEKHCIPNKIYMYKVEVHRKNVAVSSFIYRSFAEFEELHTKLRARFPMMAVSLNTISNLRSNVRAVAQKRIIHVQKFLIYLFNQVDEICHCDLVYTFFHSILRDNKCDTYIDESLDMPSQCQIYLKIEYNSVKETLSVFIGHAKYLALLQNNQQPDPYVKTYVRPDLRNQSKQKTQVVRGTRHPTFNQDLNYTEFPIEILSTRVLEVSIWNNGGYLVKHKMYMLCIPLLKVKKLAESRKNCRTLEGWFNCEKCV
The following text describes a protein:
Function:
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.
Subcellular Localization:
Secreted.
Sequence:
MRYPLAWSMCAWLLGVVGAVELTDMFGEIRSPNFPDSYPSDSEVTWNISVPEGFKIKLYYMHFDLESSYLCEYDYVKIEAEDQELATFCGRETTDTEQAPGQQVILSPGPYMGLTFRSDFSNEERFTGFDAHYTAVDVDECLEKSDEELACDHYCHNYIGGYYCSCRFGYILHSDNRTCKVECSDNLYTQRSGVVTSADFPSPYPKSSDCLYRIELEDGFFITLSFEDSFDVEDHPEVTCPYDYIKIKAGQREFGPFCGEKSPGRIETQTNSVQILFHSDNSGENRGWKLSYTAIGNPCPLVQPPINGKIEPSQAKYTFKDQVVISCNTGYKVLKDNLESDSFQIECLKDGTWSNKIPICKIADCQAPPELEHGFVTFLSRNNLTTYRARIQYHCQHPYYHMAPNSTATYTCDASGVWRSEELGTVLPSCRPVCGRPVRALPGIIKRIIGGRNAEPGFFPWQALIVVEDMSRVPNDKWFGSGALLSDSWVLTAAHVLRSQRRDKTVIPVSKEHVTVYLALHDVRNKLEAVNRTVERIILHEDFDIQNYNHDIALVKLKEKVTMGNYVMPICLPQFEHELEGPHPNTLGLVAGWGISNPNITVDEIISSGMRTLSDILQYVKLPVVLHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIQDPGTRRWVAQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVEKNTGSSERWTFLDPELER
The following text describes a protein:
Function:
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Activates MAPK signaling following TMPRSS13 cleavage and activation.
Sequence:
FLCRAFAYDRVTKRCHWLSFNSLTNGVRKKQDHAFDLYEKKDYVRNCIIGKGADYKGTISVTKSGIQCQAWNSMIPHEHSFLPSSYRGKDLRENYCRNPRGEEGGPWCFTTSPEMRHEVCNIPLCSEVECMTCNGESYRGPMDHTESGKECQRWDLQRPHKHKFRPERYPDKGFDDNYCRNPDGKLRPWCYTLDPNTPWEFCAIKTCDESIMNSTEMAAETSTCIQGQGEGYRGTVNTIWSGIQCQRWDSQFPHQHNITPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRIGYCSQIPKCDVSNEQDCYRGNGKSYMGNLSKTRFGLPCSTWDKNIEDLRRHIQIFREPDVSKLKKNYCRNPDDDFHGPWCYTDDPLVPWDYCPIYRCEGDTTPITTILDDTAIPCASTKHLRVVNGIPTQTNEGWVVSLTYRNKHICGGTLIKEEWVLTARQCFPSRYKDLKDYKAWLGVHNIKGKGEEKHRQVLNISQLVYGPAGSDLVLLKLSRPAILTNFVDIIRLPISGCTIPEKTSCSVYGWGYTGLIDYDGLLRVANLFILGNEKCNQYLKGKIIVNESEICAVAETIGAGPCERDYGGPLVCDQNRLKIVVGVIVPGRGCAIRNRPGIFVRVSYYSRWIHKIMMTYRKP
The following text describes a protein:
Function:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.
Miscellaneous:
MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MGVHSFWDIAGPTARPVRLESLEDKRMAVDASIWIYQFLKAVRDQEGNAVKNSHITGFFRRICKLLYFGIRPVFVFDGGVPVLKRETIRQRKERRQGKRESAKSTARKLLALQLQNGSNDNVKNSTPSSGSSVQIFKPQDEWDLPDIPGFKYDKEDARVNSNKTFEKLMNSINGDGLEDIDLDTINPASAEFEELPKATQYLILSSLRLKSRLRMGYSKEQLETIFPNSMDFSRFQIDMVKRRNFFTQKLINTTGFQDGGASKLNEEVINRISGQKSKEYKLTKTNNGWILGLGANDGSDAQKAIVIDDKDAGALVKQLDSNAEDGDVLRWDDLEDNSLKIVRHESSNATTAPQKRSNRSEDEGCDSDECEWEEVELKPKNVKFVEDFSLKAARLPYMGQSLNNAGSKSFLDKRHDQASPSKTTPTMRISRISVEDDDEDYLKQIEEIEMMEAVQLSKMEKKPEADDKSKIAKPVTSKGTEARPPIVQYGLLGAQPDSKQPYHVTNLNSKSESVIKRTSKTVLSEFRPPSQQEDKGAILTEGEQNLNFISHKIPQFDFNNENSLLFQKNTESNVSQEATKEKSPIPEMPSWFSSTASQQLYNPYNTTNFVEDKNVRNEQESGAETTNKGSSYELLTGLNATEILERESEKESSNDENKDDDLEVLSEELFEDVPTKSQISKEAEDNDSRKVESINKEHRKPLIFDYDFSEDEEDNIVENMIKEQEEFDTFKNTTLSTSAERNVAENAFVEDELFEQQMKDKRDSDEVTMDMIKEVQELLSRFGIPYITAPMEAEAQCAELLQLNLVDGIITDDSDVFLFGGTKIYKNMFHEKNYVEFYDAESILKLLGLDRKNMIELAQLLGSDYTNGLKGMGPVSSIEVIAEFGNLKNFKDWYNNGQFDKRKQETENKFEKDLRKKLVNNEIILDDDFPSVMVYDAYMRPEVDHDTTPFVWGVPDLDMLRSFMKTQLGWPHEKSDEILIPLIRDVNKRKKKGKQKRINEFFPREYISGDKKLNTSKRISTATGKLKKRKM
The following text describes a protein:
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular Localization:
Endoplasmic reticulum membrane. Microsome membrane. Membrane.
Sequence:
MGLDALVPLAVTVAIFLLLVDLMHRHQRWTARYPPGPLPLPGLGNLLHVDFQNIYTFNQLQHRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPAPIYQVLGVGPRSQEVLLARYGHAWREQRRFSVSTLRNLGLGKKWRTGKATPDPHLPPPGRLFRPNGLLNKAASNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEELGFLREMWSEGPQGLCRMLNVVPLLLRIPGLAGKVLCSQKAFLTQLDELLTEHRMIWDPAQPPGDLTEAFLAEMEKAKGNPESSFNDENLCMVVADLFLAGMVTTSVTLAWGLLLMILHPDVQRRVQQIDNVIGQMDDQARMPCTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGMMLFTNLSSVLKDEAVWEKPFHFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHSRVVGFLVTPSPYELCAVPR
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MAADLCWLSLLLASLALSGAVYEDQVGKFDWRQEYVGRIKFASLESGLGAKKLIAVTDKNIIAALNSRTGDLLWRHVDKDTSEGTVDALMMIGQDAITVSGGRLLRSWETNIGALNWEAALEPGSFQAVSFAGSQDTARYVAVLKNSALSLYFLSNGHLKWSESLPESDTVQYQLLYSPYKGSVHVVGLVPHSHLTILTFSLEDGSISHQVRVLTPWLRTLHGTCGVIGEGVLVCGDVPMASVHIVSLLSGEETTRYSVQSLDIELAEDPTQLDVITAPQNGIGGSLSQFFLQIAPRRFLLMHYHDGVLTPLRDFSQVSLVNFATTGEKTVVAVMQCKTEGNPKSGAESEYLTGQNCAQEPWYCPGHTYSINLYMADSGRRLLETTMSFTLDQICVRPDSFYLQTFLRKDDSVGYRALVQTEDNQLLFLQQPGKLIWLREESLADVVTMETVDLPLTGAQAELEGEFGKKADGLIGMVLKRLSSQLILLQSWSAHLWKMFCDARKPRSQIRNEINVDTLARDDFNLQKMMVMVTASGKLFGIESSSGSILWKFYLHGVHPGSSFKLLVQRTTAHFPHPPQCTLLVKDKVTEKSAMYVFNPIFGKLSQLAPPPLQRPILQSLLLPIMDNDYAKVLLLLDDQHKVIAFPATKYVLQQLQELHSTIFFYLVDVEKGKLSGLRLNKDLSTEEIWEVLLPADQQRITVVKGKRSNEHVHSQGRVMGDRSVLYKYLNPNLLVLVTESTDTHPERCFIGIYLIDGVTGRIIHSSVQRRARGPVQIIHSENWVVYQYWNSKARRNELTVLELYEGTEQYNSTNFSSLDRPLLPHVLQQSYIFPSAIRAMQATITERGITSRHILIGLPSGAILSLPKALLDPRRPEIPNEYTREENLIPYTPDIQIHAERFINYNQTISRMRGIYTAPSGLESTCLVVAYGLDLYQTRVYPSKQFDVLKDDYDYILISSVLIGLVFATMITKRLAQVKLLNRAWR
The following text describes a protein:
Function:
Integral endoplasmic reticulum membrane protein that coordinates the assembly of the ER-associated protein degradation (ERAD) machinery at the ER membrane. Mediates binding of CDC48 to the E3 ubiquitin ligases SSM4/DOA10 and HRD1, and to ERAD substrates. Component of the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. ERAD-C substrates are ubiquitinated through DOA10 in conjunction with the E2 ubiquitin-conjugating enzymes UBC6 and UBC7-CUE1. Also a component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome.
Miscellaneous:
MISCELLANEOUS: Present with 12600 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPVVNHEDSEFHLSHTEEDKLNEFQVITNFPPEDLPDVVRLLRNHGWQLEPALSRYFDGEWKGEPDQMGEPTQTSTPMAETLVPPALGPRPLLFTASLPVVRPLPANFRNDFRTIGLNGRSNTVWSMFESFSYDGNPFLFILLLIPRIINRLSATIFTFFCTLLSLHSISGGGNSGKPKISKVPKAPTRETHIPLAEILGDTKDKDAFCELKSFKPDISFNEALRIAKEEFKFMLLILVGDTYDTDTDTVDVNSKLLLEKILLNKKTLQYLRKIDNDLIIYLKCVHELEPWLVARQLGVRNTPEIFLIANVANKASHSETLPSQRLSILGKLKVNSLNRFLQSLTNVVEKYTPELVVNKTEMHELRMSREIKKLQEDAYKKSLEMDRIKAIEKEKSLKHAQDLKLNSTARQLKWLKACIDEIQPFETTGKQATLQFRTSSGKRFVKKFPSMTTLYQIYQSIGCHIYLAVYSSDPAEWSNALQDKIRQLSADDDMLCFKEGQLETATATTIEELGHIINNELTSFDLERGKLEFDFELVSPFPKYTVHPNEHMSVDQVPQLWPNGSLLVEALDEEDEEDEENEEQ
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Subcellular Localization:
Mitochondrion.
Sequence:
MSGSGLNNNNINNKKIFNVIGIETSCDDTSIGIVNSEGKIMAEYSKPQWSLHKVHNGIVPSIAFEAHQNEIDNAIEKTLDKAGMTMEDIDVIAVTTGPGMGKSLEVGLNKAKQLYREFKKPFCSVNHMEGHSLVVRMENHSIEFPFLIVLVSGGHSQILICNDVSKYQLIGNTLDDSIGEALDKAARILGCPYGQVWDGQSLIENIHGGQAIEILASKGDPNSHHFTLPMKDSNNCDFSFSGIKSSLARLVKEIKSKSSSSSSITNNTTTKTTTTTTTTTIITTETNNLITDENELSFVDKCNLAASFQNVAFNHLEHRIKKSLDWYYNFKTPKQKKNELLASKTKSGKPPAIEIIKREPLKGIVVSGGVSKNNNLRKRIDDIGKRYNLPIYFPRPELCNDNGTMIAWAGVEMFKKGMTVDDPEKVIYLPVWPLDLNPKQIFKSNLKEKDKQIRKGWYDNTIKKYGIQ
The following text describes a protein:
Function:
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.
Sequence:
MASWVFCNRCFQPPRQTACFSLTNCGHVYCEGCLGKGKKDECVICKVPCRTVLLSKHTDSDIQALFMGIDGLCKKYSKETSQISEFQEKHRKRLLTFYREKISKLEDSLRKSVLRIQELQSMRSSQQTVFSTIRNSVSTPSAQPHGCPFLPPDSSASERVESMEVDLTPSPLRKGSPPGPRLQGSLASRPEIAAGPTRISLISPPQDGRMGSVSHGPQHLGLTPGHSSMPQALRIPSLQIPCKGPSHTPAPQAPGRAGSRGSPSLGGPRAPAPRQPISISGLLQRRHAGSAAVRGFAHER
The following text describes a protein:
Function:
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MRYLITTALAYTNGPLHLGHARSTYIPADIIYKYLKLRGEDVIHVGGTDNHGVPITLTAEKEGKSPEEIVEKYHNEIKEDLDLLGVEFDAFGKTHSQIHIETAQEFYLKLKENGYIYEKEIEQFYCPNCKKFLPDRYVEGICPYCGGEARGDHCEVCGRHLEPFELKDPYCVICKGKPEIRKTKHHFFKLSALKKELEEYIKNAKEMPEHVKNMALNWIKELHDWDISRDISWGVPIPGTNQVMYVWLEAPIGYISFTKMLGEIWKKYWLEKDTKIYHFIGKDITVHHAVFWPGMLIAHGSFNLPTAVVSGGYLTLEGRKMSTSKRWVVWVKDFVKNFDADYLRYYLIMSAPLFKDCDFSFDDFKNKINNELINIIGNFTHRVLTFTHRKFKKVPIVDEDRLKEEDKELLKKCEETLEAVDKNIRSFKFRDALVNILHLAIEGNSYFQKMEPWAVDDEERLKEILYTCCKTVKTLVYLLYPYMPKKSLALLELMNEELDLELRGNELKKPKIIFKKIDNKKIEEMKKKLYENKKEETKGGEKMEQIDISYLEKIDLRVGEVVEAEDIPKSKKLLKLMVDLGDEKRQIVSGIKGYYKPEDLVGKKVIVICNLKPAKLCGVLSEGMILAAEDDEGNVSLLTVDKDIKAGSKVR
The following text describes a protein:
Function:
Controls the level of cAMP in yeast cells, together with the high-affinity cAMP phosphodiesterase (PDE2).
Miscellaneous:
MISCELLANEOUS: Present with 1400 molecules/cell in log phase SD medium.
Sequence:
MVVFEITILGANGGPTEYGTQCFILKPARTEDPELIAVDGGAGMYQLREMLVQGRNENEGDDELVPSFYEHDREPIEFFIDSKLNIQKGLSKSLLQSLKRQGEHFESANTMKKTYEVFQGITDYYITHPHLDHISGLVVNSPSIYEQENSKKKTIWGLPHTIDVLQKHVFNDLIWPDLTAERSRKLKLKCLNPKEVQKCTIFPWDVIPFKVHHGIGVKTGAPVYSTFYIFRDRKSKDCIIVCGDVEQDRRESEESLLEEFWSYVAENIPLVHLKGILVECSCPLSSKPEQLYGHLSPIYLINELSNLNTLYNSSKGLSGLNVIVTHVKSTPAKRDPRLTILEELRFLAEERNLGDLRISIALEGHTLFL
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MTHSRTALVLIHPATTTRPELLTAAKQHSSLSGANIEQHLVNKLNDGSLQLQDNSYDVIFYVTPEAADEILFPRRLIGVLAAALRAGGSLHGLYDKYQVDALLSGFDIVREPTYHWQKRAVTASAPVKLAPRQPVSAAGLPRFKRASAPSPAAVTPTLDEVPPAAVDPVKAALLDSAAGDAPIAENDLVVGHDSTPITLLTCGRTQTRRRKACKDCTCGLREENEKEISDTHARQEKLLLGDAVKFSEPELAEIDFTIEGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLSAISDDL