lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for transcriptional activation of glucose-repressible alcohol dehydrogenase (ADH2).
Subcellular Localization:
Nucleus.
Sequence:
MANVEKPNDCSGFPVVDLNSCFSNGFNNEKQEIEMETDDSPILLMSSSASRENSNTFSVIQRTPDGKIITTNNNMNSKINKQLDKLPENLRLNGRTPSGKLRSFVCEVCTRAFARQEHLKRHYRSHTNEKPYPCGLCNRCFTRRDLLIRHAQKIHSGNLGETISHTKKVSRTITKARKNSASSVKFQTPTYGTPDNGNFLNRTTANTRRKASPEANVKRKYLKKLTRRASFSAQSASSYALPDQSSLEQHPKDRVKFSTPELVPLDLKNPELDSSFDLNMNLDLNLNLDSNFNIALNRSDSSGSTMNLDYKLPESANNYTYSSGSPTRAYVGANTNSKNASFNDADLLSSSYWIKAYNDHLFSVSESDETSPMNSELNDTKLIVPDFKSTIHHLKDSRSSSWTVAIDNNSNNNKVSDNQPDFVDFQELLDNDTLGNDLLETTAVLKEFELLHDDSVSATATSNEIDLSHLNLSNSPISPHKLIYKNKEGTNDDMLISFGLDHPSNREDDLDKLCNMTRDVQAIFSQYLKGEESKRSLEDFLSTSNRKEKPDSGNYTFYGLDCLTLSKISRALPASTVNNNQPSHSIESKLFNEPMRNMCIKVLRYYEKFSHDSSESVMDSNPNLLSKELLMPAVSELNEYLDLFKNNFLPHFPIIHPSLLDLDLDSLQRYTNEDGYDDAENAQLFDRLSQGTDKEYDYEHYQILSISKIVCLPLFMATFGSLHKFGYKSQTIELYEMSRRILHSFLETKRRCRSTTVNDSYQNIWLMQSLILSFMFALVADYLEKIDSSLMKRQLSALCSTIRSNCLPTISANSEKSINNNNEPLTFGSPLQYIIFESKIRCTLMAYDFCQFLKCFFHIKFDLSIKEKDVETIYIPDNESKWASESIICNGHVVQKQNFYDFRNFYYSFTYGHLHSIPEFLGSSMIYYEYDLRKGTKSHVFLDRIDTKRLERSLDTSSYGNDNMAATNKNIAILIDDTIILKNNLMSMRFIKQIDRSFTEKVRKGQIAKIYDSFLNSVRLNFLKNYSVEVLCEFLVALNFSIRNISSLYVEEESDCSQRMNSPELPRIHLNNQALSVFNLQGYYYCFILIIKFLLDFEATPNFKLLRIFIELRSLANSILLPTLSRLYPQEFSGFPDVVFTQQFINKDNGMLVPGLSANEHHNGASAAVKTKLAKKINVEGLAMFINEILVNSFNDTSFLNMEDPIRNEFSFDNGDRAVTDLPRSAHFLSDTGLEGINFSGLNDSHQTVSTLNLLRYGENHSSKHKNGGKGQGFAEKYQLSLKYVTIAKLFFTNVKENYIHCHMLDKMASDFHTLENHLKGNS
The following text describes a protein:
Function:
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.
Sequence:
MDLSEVRDTFISESEELLSSMESNLLILEKDSKNNEGIHSVFRAIHTIKGTSGMFGYEPIEKFTHEVESFLDRIRSNKQSLTKEGIEFLFLACDHIRNLLQGVGETLIVDSQTSRNQVNLLSLAKKLTLDDTSNPQKDEVLVQNQSTSSNLLDSHSSSTFWQITLIPNIHLFESGLDPSTFIKYLSQSGKVKHIFVYPESIPNWSEFNPEHSHLGFEISYESPSKGEEIYSTFQFLKEGSYLKILSPGCSLNLFMENCNDFPLGKKAYLNALEIQKVLTPEEIQKLSYTSENLNVLSTTQTEQTTTSIENQKESDSIKIQTKTLRVDSSKIDTLIALVGELITQEANLSRKISDSENLQLIESSESLYRLVTEIREFALSLRMIPISDLFEKYKRVVRDLSKELNKQVELEIIGGETELDRSVIEKISDPIVHILRNALDHGIETSEERIKKGKHATGQLKIQASHGTGSILIEIKDDGKGLDCDKILEKAISKGLITRDQNLSESEIYSLIFQPGFSTADQVTNLSGRGVGMDVVLRNIESLRGTVQIQTLKDQGSSFQIRLPLTLAIIDGFLVKASSLYFIVPMQMVRETVESKVILNGSSSGTMNLRGELLPVLHLSEFLCLESTYFEKENILVLEYEDKSFGIIVNDLHGEVQSVIRPMAEIFKNIKCFSGTSILGSGEIAFILDVPGLYNSIRDQELNKNKDLVTKTG
The following text describes a protein:
Function:
Torulene dioxygenase; part of pathway that mediates the biosynthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigments and leading to orange pigmentation. Cao-2 mediates the cleavage of torulene into beta-apo-4'-carotenal, the aldehyde corresponding to the acidic neurosporaxanthin. Is not able to use gamma-carotene (that it is not desaturated at the C4'-C5' bond) as substrate, which suggests a high specificity of cao-2 in cleaving the C4'-C5' double bond. Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene. Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene. Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta-carotene by an additional al-2 cyclization reaction. Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSPHEVIGTVPKNSTTFRTQADEHDDHEEALQNLRTGKYEDWPNEAAFDGLTEERGPIKIAVTGNIPTWAAGSLYRTGPGLYKIDTDAGTTFEMSHWFDGLAHTHRFDIIPNEEGSVDIFYSSRRQAEEMMDVIKKQGTWPYYSFGQKADPCLGFFAKAMAAFKGLREPSGEKWHNNVNVAVHVNPPGLEAVRNIVGTRKPAVAENDANVLGHRPELPKSIWVSTDNSTMKQIDPQTLEPIGWATQDVLHPELTGAMSCAHAQRDPDTGDFFNFNLEFGPKPTYRVFRVDASSGKTEILATIREPSVSPAYIHSLFLSPSFVILCIPTSHFGLSGTQIPWERNLVDAIKPYDPSRKTQWIVIDRKHSKGVVARFETDGRFFFHTVNSFEEKAGSDSSDINLYCDVIDFGSHEFIHSLYLDVILNRDSAAKKFYEDEQRARNSLAHLTRYHFIINPDSPTTNLPVTPTPDPKNHEAFRIPAPHAGEIPTINPLYATRKHRYVYSLPFRGRGTITDAIVKTDTVTREALFWDNPKGHTPGEAIFIPRPGGEEEDDGVLLSLVLDGEKGKSYLLCLDAKTMAEMGRAEVDFAIALGFHGAHVPSGRTLTRVEGPEY
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MDSNKPSTATSSASKENRTADPTAGLPYYEETRRKLKQLLEQKKSLDRILALSEDSIFRKETEYLDETPQGNIINGFDGYAKGAGVGGVGRGAGTGRKSAAAGGTDRPFSGSSYSWRVNVDSPAPSGASTPVAAMAPTPLSMTFQKNGESSSNHPTPTSATSGKGKKNKKMAGGDDSETDTKDSTGNKKARTNFGATRK
The following text describes a protein:
Function:
Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein that acts as a component of a complex regulating the turnover of mRNAs in the nucleus. Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs. May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucleus (By similarity).
Miscellaneous:
MISCELLANEOUS: Plants over-expressing UB2A1 display severe growth defects consisting of premature cell death and chlorosis.
Subcellular Localization:
Nucleus. Note=Mainly localized into nuclear speckles.
Sequence:
MDMMKKRKLDENGNGLNTNGGGTIGPTRLSPQDARKIIERFTTDQLLDLLQEAIVRHPDVLESVRLTADSDISQRKLFIRGLAADTTTEGLRSLFSSYGDLEEAIVILDKVTGKSKGYGFVTFMHVDGALLALKEPSKKIDGRVTVTQLAASGNQGTGSQIADISMRKIYVANVPFDMPADRLLNHFMAYGDVEEGPLGFDKVTGKSRGFALFVYKTAEGAQAALADPVKVIDGKHLNCKLAVDGKKGGKPGMPQAQDGGSGHGHVHGEGMGMVRPAGPYGAAGGISAYGGYSGGPPAHHMNSTHSSMGVGSAGYGGHYGGYGGPGGTGVYGGLGGGYGGPGTGSGQYRMPPSSMPGGGGYPESGHYGLSSSAGYPGQHHQAVGTSPVPRVPHGGMYPNGPPNY
The following text describes a protein:
Function:
Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Required for collagen quality control in a LIR motif-independent manner.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The LIR motif interacts with ATG8 family proteins.
Sequence:
MASSGGGNTGAGGTSGLGLGLGLSLGMGEATGDAEEEAAAAEAVGRLATSLWLRLRGWEAVLAAAQRLLVWEKPLHSLVTAATLNGLFWLLSSSSLRPFFLLSISLLTYFLLDLWHPRFLPDVSAPPPEEPHSDSEGAGSGAQPHLLSVPELCRYLAESWLTFQIHLQELLQYKRQNPAQFCARGCAACAVLAVLGHYVPGVMISYIVLLSILLWPLVVYHELIQRMYTRLEPLLMQLDYSMKAEADALHHKHDKRKRQGKSAPPAGDEPLAETESESEAELAGFSPVVDVKKTALALAITDSELSDEEASILESGGFSVSRATTPQLTDVSEDLDQQSLPSEPEEALNRELGEGEETELASPEDLLSAPPALSKQALDTEEEGAADKEALLQLSSPLHFVNTHFNGAGSPQDGVKCPPGAPVKTLSPEAVSGDLMAPSSTLSPQLCLAESGPVTPLSPSVLPSLPQDSPQPLAAPEEEEALTTEDFELLDQGELEQLNAELGLGPEMPPKPPDVLPPPPLGADSHSLVQSDQEAHAEVEP
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MAVQPKETLQLEGAAEVGFVRFFEGMPEKPSTTVGLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKTLQTVVLSKMNFESFVKDLLLVRHYRVEVYKNKAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMATSIGIMGIKLSTVDGQRQVGVGDVDSTQRKLGLCEFPDNDQFSNLEALLIQIGPKECILPGGETAGDMGKLRQVIQRGGILITERKRIDFSTKDIYQDLNRLLKGRKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAAFLNKCKTAQGQRLVSQWIKQPLMDKNRIEERLNLVEAFVEDSELRRALQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGVKQLPNVIQALEKYQGRHQALLLAVFVTPLTDLRSDFSKFQEKIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLISAARGLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSGYVEPMQTVNDVLAHLDAVVSFAHVSNAAPVPYVRPVILEKGKGRIIVKASRHACVEVQHDVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATNIGAFCMFATHFHELTALASQIPTVNNLHVTALTTEETLTMLYQVKTGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQSIGTSQGHDETQPAAKRRCLEREQGEKIILEFLSKVKQVPFTDLSEESVSVKLKQLKAEVLAKNNSFVNEIISRVKAP
The following text describes a protein:
Function:
Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular Localization:
Nucleus.
Sequence:
MKKWLGFSLTPPLRICNSEEEELRHDGSDVWRYDINFDHHHHDEDVPKVEDLLSNSHQTEYPINHNQTNVNCTTVVNRLNPPGYLLHDQTVVTPHYPNLDPNLSNDYGGFERVGSVSVFKSWLEQGTPAFPLSSHYVTEEAGTSNNISHFSNEETGYNTNGSMLSLALSHGACSDLINESNVSARVEEPVKVDEKRKRLVVKPQVKESVPRKSVDSYGQRTSQYRGVTRHRWTGRYEAHLWDNSCKKEGQTRRGRQVYLGGYDEEEKAARAYDLAALKYWGPTTHLNFPLSNYEKEIEELNNMNRQEFVAMLRRNSSGFSRGASVYRGVTRHHQHGRWQARIGRVAGNKDLYLGTFSTQEEAAEAYDIAAIKFRGLNAVTNFDINRYDVKRICSSSTIVDSDQAKHSPTSSGAGH
The following text describes a protein:
Function:
Transcription factor; part of cell wall integrity (CWI) signaling pathway composed of pkcA, the bck1-mkk2-mpka MAPK cascade and the downstream rlmA transcription regulator. The CWI signaling pathway regulates cell wall integrity and pyomelanin formation. CWI also controls oxidative stress response, gliotoxin production, iron adaptation and asexual development. Finally, CWI is constitutively required for A.fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection. Positively regulates the phosphorylation of mpkA. Involved in tolerance to oxidative damage and transcriptional regulation of genes related to oxidative stress adaptation. Directly regulates the expression of regulators of conidiation, including flbB, flbC, brlA, abaA, and rasB, as well as genes involved in cell wall synthesis and remodeling. Specifically associates with the target fumiquinazoline (fmq) cluster genes promoters at conserved motifs (5'-TAWWWWTA-3') during conidiation to supplement mature conidia with fumiquinazoline C. Also controls the DHN-melanin production via binding the promoter of pksP.
Subcellular Localization:
Nucleus.
Sequence:
MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELAVLCSVDVAVIIFGHNKKLYEFSSCDMRETLGRYQYYGPPHEHKGPEDFNGKRDDDDDEDETTPAPEEMQPTTQNPPAVVPAHIPSHPGFQHVNHAPSASPPISNGIPFDPRHGTPQPQGASRPSSRNHLRRVSSNLGPQQHHGTPPPPPQNGFAYIPNPSMYHPNANPNIAQQPRPPQFAHYGPQQPLPPHAIPPHPMPQPVPPHHQAPQHLPQHPHPLAQQTPAMGLSQPPHASIPQVAQPFLPEQGRNSIPPAFPTEQSQPPRPVSLPDVSSADQMVGPLKVETSPSPPHQRSLSSKSRSIFTPIDDRGSVLARHFGLGPPTCESPRTESADVKAEAKQNDSKEIKPPAQPVAPPPPPRTTADAARSQSAPDIKPPPRTNSGQLPSKRPQLKVQIPSENSDRGSATADSSSSTGNQTVTPAKANPDTNHSGVVLPPPSPSAGAILSAGATGPPNPFARPPPPGTASQNSNAYNSNNNIETPISALPSRFVSDALLPSPSSFFPEWGFGRSGPDTNMLPSPLTFPTPAVQTGPGFAREDEQEKKRKSPDSGPSIEGTAKKSKT
The following text describes a protein:
Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Sequence:
MTLLPGYPAPAFKLPGDDGRWWGLPDLRGQAAVLYFYPLAHSRDCALEAMAFEVLLGEFAAAGARVLGISTDSRAQLARFRHAQGLTFPLLSDAGREVSRLYGARRSPWGLVGRAGRQTYLLDERGRVVHHWPQVDPAWHAQAVLDTLRRWRDGQDGAVTLGA
The following text describes a protein:
Function:
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Sequence:
MKKINKQALIDAVEQKQLKEYVPEFGAGDEVNVAIKLREKEKVRVQNFTGTVLRRRGRGISETFMVRKTTDGIPIEKNFQIHNPNIDIEVKRRGKVRRAYISYMRERSGKSAKIKEKKS
The following text describes a protein:
Function:
During inflammatory stimulation, plays a role in retaining Cxcl13-expressing cells at the site of the inflammatory response.
Miscellaneous:
MISCELLANEOUS: The human orthologous protein seems not to exist.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=In unactivated neutrophils, the majority of the protein is contained in intracellular granules and is released to the cell surface following inflammatory activation or induction of necrotic or apoptotic cell death.
Sequence:
MLGQCTLLPVLAGLLSLESALSQLCTKDNVSTCQDCIRSGPSCAWCQKLNFTGRGEPDSVRCDTPEQLLLKGCTSEYLVDPKSLAESQEDKERDQRQLSPRNVTVFLRPGQAATFKVDFQRTQDNSVDLYFLMGLSGSAQGHLSNVQTLGSDLLKALNEISRSGRIGFGSIVNMTFQHILKLTADSSQFQRELRKQLVSGKLATPKGQLDAVVQVAICLGEIGWRNGTRFLVLVTDNDFHLAKDKTLGTRQNTSDGRCHLDDGMYRSRGEPDYQSVVQLASKLAENNIQPIFVVPSRMVKTYEKLTTFIPKLTIGELSDDSSNVAQLIRNAYSKLSSIVVLNHSTIPSILKVTYDSYCSNGTSNPGKPSGDCSGVQINDQVTFQVNITASECFREQFFFIQALGFMDSVTVRVLPLCECQCQEQSQHHSLCGGKGAMECGICRCNSGYAGKNCECQTQGPSSQDLEGSCRKDNSSIMCSGLGDCICGQCECHTSDIPNKEIYGQYCECNNVNCERYDGQVCGGPERGHCSCGRCFCRYGFVGSACQCRMSTSGCLNNRMVECSGHGRCYCNRCLCDPGYQPPLCEKRPGYFHRCSEYYSCARCLKDNSAIKCRECWNLLFSNTPFSNKTCMTERDSEGCWTTYTLYQPDQSDINSIYIKESLVCAEISNTTILLGVIVGVLLAVIFLLVYCMVYLKGTQKAAKLPRKGGAQSTLAQQPHFQEPHHVEPVWNQERQGTQ
The following text describes a protein:
Function:
Probable membrane-associated metalloprotease that may be involved in chloroplast development.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MSSLPPSQAAAAAYGCFHRLLLASTTVPARSGCVGRARRLTLALRCLPIAGHRLRSRKVACQAMTETESEGDGDKEEKKEFGDDASSPSVDSVAEANGPAESDSSIDNKKDETANAELLSSSDTVQNVDGDATSTNDVQENVEVIEVVSGSPLPGMKQQLDDSVRIPKATIDILKDQVFGFDTFFVTSQEPYEGGVLFKGNLRGKPAKSYEKITNRLQNKFGDEYKLFLLINPEDEKPVAVVIPKQTLQPETTALPEWFAAASFGIVTIFTLLLRNVPVLQDNLLSTFDNLELLKDGLSGALVTALIIGVHEIGHILAARESGIKLGVPYFVPSWQIGSFGAITRIVNIVRNREDLLKLAAAGPLAGFSFGFVLLLLGFILPPSDGLGLVIDPTVFHESFLVGGLAKLLLGDVLKEGTELSINPLVLWAWAGLLINAINSIPAGELDGGRIALAIWGRKISSRVSSLAIGLLGISALFNDVAFYWVVLIFFLQRGPIAPLSEEITDPESNYIGIGVAILLFGLLVCLPYPFPFDPSQLTDMDFNF
The following text describes a protein:
Function:
Specifically hydrolyzes gamma-D-glutamyl-L-lysine bonds in murein peptides, releasing L-Ala-D-Glu.
Sequence:
MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDERLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKTKPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQSDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRDAGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEILTLTETIYEKELCAVRRCFSE
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
PLFLVFLFVCVGGMACIACYSFLYGSPFRYVYGADSWGNVCGRKGNVQVMGVQHSGMDMSETKMAAFEDAGNRCVVSKVKLVELAELVELADLVELAELVELAELMELAESVELAESVELAELVELAESVELAEVMELAGSVELADLVELAESVELAESVELAELMELAESVELAELVELAETFPRAAIILTLANFVLVSAACTAFLIYRTILAWPTHTVVIMGTIADPVITDDTSAAKDQHVGYVTLIPLHIRLLIGSIVCGLFSLTLLSILIWSRKTISFLIDLNIEVSELLQEILTIYTQPLVTLLFQLGIFFYFVAVSLYLLTIYTPRPDADGMVLYVPEPVLQTVGLLILHLILTWWFLSFVDGCNQCIVSGALSWYIFYYATASDCSLCFPTVKPFVHTLRSSLGSITLGSIIEPITRLPRLVLSSLSSVAKPAQVRPAGLTLEYLSQLSYIRIGMYGEKFLQSGKVGFTVLHSIAPQLIPLLRKNRFCLYLGKVAAGILTAVGAISLMYFYLEVQITENYGEVVTLIVPACVLAYTVTSCFFNFYNTAAETMFMSYCHDRQIND
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MANSNRGKPIVVENIATFRRSQSPLDVFVIPELSQKRKLTDVPFLITLAICVVVLMIAMIYTLYYSDMNRFTNGYDNCGNVCGEKNSHVDGIPCSGQDMTNKPYLVGGKCVERCADADCSTSDVWNEFNEKLGPMAIVCCIGLGLSIIALFCFRYFVDVFVWTMLIGAVLLMCALTGYIWYCYANQSSEQGSGLLIGAIIFTFISLIFAVFILVLKDMIKLIIRFYEETIKMVFAMPLILLEPVLTFISIFVIVGLCVYTFILMNHAGKLQETGDSSYPYRIKASRYTKDSVLPVVIGAVFAFLCIHCIFVVFEIDVDAVFICYCEDNCLNNGTTEPFYATVEFYQQVKKAQAVTKSIEAKKKKK
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MASRLFFKTATPLSFAAIAVASAPVAFAESPRRSIYDNDKKEEEIAPVPGTVETGKAREGDIEKFEKEHGVSVENVGGVTIKSPKALESNIKVAREWFADKVQQGNQYIDEAFNKYLAVENSVTKTVADLKSPQEDILPAGIYITVAALSGSILTRNRNILFRSAIPLAFGVAAFSYFLPQTAHNTGALVWKYEQKVPEVAKAHVDAKESVDSFAKNVRKALDDGKTSLESGVHSTRKFIADSTGLQLPDVDENDKKK
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MKVAITGKSDMKMNNANDDGDSKSMLACKQPMQVQHYNMVTTVCGAACCKEAHAFQPHIRCTCTPSTEISVKVKCPKLDGDIYTKELHCLYCNRHHSIFEEAFAACCHPQPIPTPSQLSPQMAKNDPCLKVQRALTPPPTATHLTPPRLISSVSETDLNCKFQMHCCNSKCNWLRSLSPCQETQPPKQLKWQEGCNQSLVKVTKHDVGTMTIQRVLKNAGVQTRQTSSHGFPQLSVANERKNKFFNSLNSNKDERVGNAKSPVKDVKWDAEGMTWEVYGASVDPEELGLAIQRHLELQIKETASRVTKLMRQNTNTSQQSMNVSSNRKNSRMTAPFRRMTCCSYSTAVND
The following text describes a protein:
Function:
Receptor-like serine/threonine-kinase required during the endosperm development in seeds.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKNLCWVFLSLFWFGVFLIIRFAEGQNQEGFISLDCGLPLNEPPYIESETGIQFSSDENFIQSGKTGRIPKNLESENLKQYATLRYFPDGIRNCYDLRVEEGRNYLIRATFFYGNFDGLNVSPEFDMHIGPNKWTTIDLQIVPDGTVKEIIHIPRSNSLQICLVKTGATIPMISALELRPLANDTYIAKSGSLKYYFRMYLSNATVLLRYPKDVYDRSWVPYIQPEWNQISTTSNVSNKNHYDPPQVALKMAATPTNLDAALTMVWRLENPDDQIYLYMHFSEIQVLKANDTREFDIILNGETINTRGVTPKYLEIMTWLTTNPRQCNGGICRMQLTKTQKSTLPPLLNAFEVYSVLQLPQSQTNEIEVVAIKNIRTTYGLSRISWQGDPCVPKQFLWDGLNCNITDISAPPRIISLNLSSSGLSGTIVSNFQNLAHLESLDLSNNSLSGIVPEFLATMKSLLVINLSGNKLSGAIPQALRDREREGLKLNVLGNKELCLSSTCIDKPKKKVAVKVVAPVASIAAIVVVILLFVFKKKMSSRNKPEPWIKTKKKRFTYSEVMEMTKNLQRPLGEGGFGVVYHGDLNGSEQVAVKLLSQTSAQGYKEFKAEVELLLRVHHINLVNLVGYCDEQDHFALIYEYMSNGDLHQHLSGKHGGSVLNWGTRLQIAIEAALGLEYLHTGCKPAMVHRDVKSTNILLDEEFKAKIADFGLSRSFQVGGDQSQVSTVVAGTLGYLDPEYYLTSELSEKSDVYSFGILLLEIITNQRVIDQTRENPNIAEWVTFVIKKGDTSQIVDPKLHGNYDTHSVWRALEVAMSCANPSSVKRPNMSQVIINLKECLASENTRISRNNQNMDSGHSSDQLNVTVTFDTDVKPKAR
The following text describes a protein:
Function:
Binds anionic lipids and gangliosides at acidic pH.
Subcellular Localization:
Lysosome lumen.
Sequence:
MAGRARLWLLAGLWVCALGGLGAPGTPRPCRAPQQWEGRQVVFRQSSGRNSRALLSYDGLNRRVRVLDERKALIPCKRLFEYILLYEDGVMFQIEQATKQCSKITLTDPWDPLDIPQNSTFEDQYSIGGPQEQITVQEWSDRKSARSYETWIGIYTVKDCYPVQETFTRNYSVLLSTRFFDIQLGIKDPSVFTPPSTCQTAQPEPMSENCSWQ
The following text describes a protein:
Function:
Important for the biogenesis of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations. Required for efficient incorporation of the eisosome component PIL1 into eisosomes.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to eisosomes.
Sequence:
MFRRRTTAPEMEQADPTAVAAAASIGKLLMKKGNQSDNEQRPTYRSASMTNLRKPSAPKRMSSISSISSESRRSDGKGRPGKINSLTQRSSMGKGDSLNSPLTKEPQHKTRSHNRTSSLPNQRGQQSRNSSGLQRQKSKTHQRISYDEAQRTFKDFGGPQARGILTGQHRTENPSGSIPLRTTRKYIPGPNGLVAIEVPVEKPSNANTSKLLRRSNSAHSALNARNGSLLRKKVSQESLHSQPKKTSSLGNTSSTQAKKGQKAVQERNLAKKHPINSNVPLIETQVREETDQELKLDNSNSSESETVVNSENNLEKPSSLNIEKDDLSKLIHENIELESFIEEKGKEKPLNSDQEDVFISEKTVKGDVQWPKNNRQASTLEKTFNYDNEEKREGNKPVAEHPLPEAEVDDKSVEQLNNISSSGSYSAQGSVENSKPENGNKNLENDTTSSPTQDLDEKSRSIEEKDTLEGTESSKKVEKPDNCCEKISGANTSSKKGNVGDTKDEFFDTVEESDQKTSKSNSSKNTDHSNQTEPTPSLAQYLRTSNTYLSRKNQSKQAEQEKFHKPEAPMVPVTKVVTPIKSALKKSSGSSNHDSSMYSDNSPANGAYLSLTTAENTRLNAQMTMSDSVSRRASLKRSSIKRPQSVGQFRSIRSNSPSPPEKINNKRHSAIPLGTPEKGKPKRNSVMASLSKNSQQIQEPASVYESNGPNKPKNQINKNIKRGSQIAQNNKPSTKDMNSILYPKEPPPRKSSFEKTRSNESHLGFKKLSLRNGNFEEALSESYNGQASQNSTNVNRTDTAQEFFKYLGHSSRFADSDSEDESQFFNQGPSKYNTETEGNKTSGNKNSNGGNGAFSLFKSKSKQKENNVVSPGVSSPNHTTTDPAITSKKVDKKFSGLSLRAASEAEPAKNSNPSMTNRLRFSSNPENGESRLPQAQEVSVTKEKKGSFGKKLKKIFGRKK
The following text describes a protein:
Function:
Required for the maturation and activation of urease via the functional incorporation of the urease nickel metallocenter.
Sequence:
MATGKVVVEKVGGRSTATSCFSKYPLKFLLPSKAAPAGTDVVWIYSITYGGGIVSGDSISCEFTIGDGCTAVITTQSSTKVYKAIGSKCSEQILEARIGSEALLVVIPDPVTCFSTARYYQKQIFRLLSDSNLVLVDWITSGRHANGEKWDFEFYKSINNVYLEDDHPLFLDTVLLEKRSIQSIAERMQDYQAIAMVILFGAKLKEIQKQVQENVKNMMSEQLQLSYSSRRHKSESSSRNRFMKPEFIASCSTFGPEGKGVVVRIASDSTESVYNFLRQQLAELEPVLGQAPYA
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MIINFVGNTLIIFNEDIPCDLLRKKYKELFVPTISVLDFKKKRLYRKYNNIFLYTYKNYSFLWELENNILHKVQKCLNKNGILKLIIYLNKNDVITPDKHENKNNNDIKVNIDQKDYCENYINDIFKNIKKECLYNGFINIVNETSVAENGIILNITAENPDFLSNEDNDVSSDDEDLYNNEDDKKKVVNRVCDNCTCGKKEKLLNSENKVLINEKDGEYITENVVSSCGNCYLGDAFRCASCPYKGLPAFQPGENVKLNLNNESN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
IHIWTLPKPPLTLPHGFTTTKAAPARGPRPSKPRHRCSECGQEFSRPSRLADHVASHSGVKRHSCSICGKRFTKKFNLRIHQRVHTGEKPYSCPDCSASFCGRGFTQRRYLVQHERTHTGEKPFSCLLCPKRFASRNGLVDHHKTHAEQKLFSCSLCQKAFSSASSFRDHVRLHTGQKLHPCSLCSRSFNRPSKLRGHLQRHADEAAGAVSGGGGGGGGGGDPHLTRLTPQGEAAPHCFLCQEDFSSIEQLQEHRRLQHPAPRFACSVCGRTFTRTTRLKVHMKSHSAGGPQQNPEGRRRGLKAQGKPKKNLAQGCSGTATPPQVRGRQGGKSPRQTGGLGGGANKGNPLFEHLCPVCGRDCFKASALQKHLRIHSGERPYQCPTCSKSFVQQVHMKEHQRIHTGEKPFTCPQCAKSFTFSSALRRHQRLHDDARPFCCHVCKKSFKQRSVLKSHLLTHSGVRYQCPLCSRSFSRALELTYHVDVHSEARPYFCSICNLDLSGARIFRNHMRKHESAGRPAGSEETM