lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis (By similarity).
Sequence:
MAHYFKVDLDEEFERFMKELSDDSFENSNKTPRQPNEDNKEMKKKDPVPWWIAEDDFEDDGLLGTNVSYLKTKKTYQPVMDTEEESAEKVQFLKSSGTSILSVDSLEANELVVSEPHHSTLGLGLDTLEEQEEKEQFFARLEKGLTSSIDYSKLNQELDSDDSAQLKALHRYPRNTEPAEDGCENESEQEELPETYSDDFEDAEDADDPLITKDEETHPKENSESGKDSFPKQEEEKTGMLANVVLLDSFDSVEDVGLSSQEKATPKAKAPPEITDDGPAETGVPYGQSSGDTEALHQAYCHVAHSLGDTGEPRIEASTVQTVRSSIKDGLQENEESSKNVSTTESDLPTVEELMQPIRIDSYGIRAFDLQPISLKKATDSKEAESVGSLPLKTNTNTVSQDTRHAIQFPHKHDESVVLHRTADEGMGSSCPATEEHLDKMYLEILKKKTSVNPSLLPQDDKMNQTSRSQLGAGEEVPVIGKQVPCKKARSTPSLPKRKPQSGLYASARSSGYGKPSSPLQLFSALEKKTSKDNTKTKSVRSIPTSNQFRKREILSGTKLIKPAASNKPSPHREGSPATPKRPEDPSDDSFVQLQTEPLGSYGGNREKELLMLKRAQDAEEKWTGAQALMEQMKMTFCEKEKELENTVESLKRQQERELFRLNQENYILQAKLSSFEETSRKQRWLQFGETSDPLTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQNLFSELASLKEQMHKNHFLSQAVENTEPTKNQSFTDLLAELRAAQKEKNHLMEDIKRLKQDKQALEVDLEKVKRERDQAKDQIAYATGEKLYEIKILEETHKQEVSRLQKRLQWYAENQELLDRDAARLREANEETEKLRLEIEKLKTESGSPATQQRLRSKERALDAKRIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDSVDRNTVEFMERRIKKLEADLEGKDEEAKKSLRTMEQQFQKMKIQYEQRLEEQEQLLAHRQKEAPQSQRNSSSRLKALETELGDIKEAHQITVRKLEAEIDVLKHQNADLEHKKNDKGDQGLQSIEFQVEQAQARAKLARLNEELAAKGREIQDLTKTVERLQKERRMMLSRQIPRSREETAAKRLKKDPNRGHGNAFPETLDGKLYHPHTFTDSHISEVLEENYRLRSELEGLILERSKLKMESEAAVCQLENSMKRVKDDAAAHIASLKASHEREIEKLLCQNAIENSSSKVAELNRKIATQEVLLKHFQGQVNELQGKQESLAVSQVREEILQKQITKLLEELKEAKENHTPEMKHFMGLERKIKQMEMRHRQREQELQQIIQQTRQVVETEQNKEVEKWKRLAQLKNRELDKFRTELDSILDVLRELHRQGVVVPMALAGEENTAEF
The following text describes a protein:
Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Sequence:
MFVRALRLINPMGFQCRTFRFCSTTQNKELLEEVTAKVLQVMKSAAKCKVDKLSDKATFEELGFDSLDAVEMVVALEENFGFDIQNEEAERIKGVNEAIAVFYKYVVQRNQTSVKQ
The following text describes a protein:
Function:
Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase.
Subcellular Localization:
Nucleus.
Sequence:
METPTGSGRPSRMATPRLSERKRQLFGSPRSRLRQINDDEDDADVDSLGVLPLKTHVAANRKGRSLFAAVPGKSSSSANSSPETNKENKKTRGGVMTATAEQLPQLFTATMRLNSNSSSNSRNSSPRQTRVQRKRADSSMSSPTSSSEGTPSSRARNSIRRSPRTFSAQKDPDAFSSPESFQTRLSKVAAMLMKGQDSRSMLEKSKKKHNHSLKTTAQVHTTKPKKTSPAEESQSDDEKPSSSKNSRKNTEVRETRSSQIISPKTRNRRRPFTSADINCKTLKAAAHLHENMRSYDEEKTAAVKLENSRSRSKSPVEVFKSNDDAVKRNTGNTNNKTAKSSEVATAKRPESPGSSMKIDVEVPESDEEASNHKPQKRQHPETSTPVAPSADADSGSPQSKMRKVTLSSSIPTMAFYSHSGEAVTKSRRRPSISKNSLKQPTKISPTSRPLLGINKGVHHKIRKRHGFANRLPATDMDNILNSLSNERLKNLITTKREERAKVEEVHQILRNAKDPIKMAKPLSVIEADDANNNNNLPATAWQETSADFSDLSDVEDIDPIIEVEPIIPIIRHEPVQKSPTAEPADLSKRKFFKSGRRSSTCMEVRITDNIRASVSQGKIELVQTIRRKPRQVRVKSATIFSAEQATVDAILKNLDDTVVDEIVEANPVVQATPIDAEETTMETESLPDIIEYAPEANDVEIDPFAEFRQRLPYQTDDPNVVEQQQILLEFLISNNICTEKNFEIFIANPDDYKDEANQIVDNLYMVVNSEEAAQLAQMETVENTAVAIAPKQDAPAVEEVQPKLFPIFTQRLQPVVQKSLRRRPDTSMRLLTAAGGSNQYQIDAGQKAFGARQCQQCGLVYTVHEPEEELLHREYHNSIHVLRFKGWIDEDIVSVYPEWASDGRIIRINERAPTARLDRLRDLIGVVDKELGYSSYIVPKIFVAFIAVRKQQIVGFCLVQPLSQAHRFIQVDGTDYFSEESYPASCGVSRIWVSPLQRRSGIASKLLRVVQCHTVLGQEIARECIAFSTPTDDGRALARQFTGLDNFLTYDQ
The following text describes a protein:
Function:
Polynucleotide 5'-kinase involved in rRNA processing.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAETDLNALAYKDSDSTDTSSSSSSDEEYQAEVKVSNQNEKQVDYDSDTDLNTDNKVSSVDAYKPCVGENLIIRDSNIIILLRAKEKLCLSGLFDLKIEKGGLLYNDIHFNASSKTYHYWHPLSNSIPEIKSSFYAGFEDVDISAFYAAYDISPNNDYETVLKISNHKSKSLIDGEILMPSLKSLWITKEDFLQKNGYTNFSFDIIMPATLQEITTLNISKSWTNCLQKLKFINQNSIHDTRIMVIGGKNSGKSTFLRSLVEKVLYSHDISDKSVSEMLYLDLDPGQPEFSHPDCISMTRLTSNDMNFGQSFGQASPEVLKQYYIGSPSPQEYPTRYLNMVNKLITEFEDTMFAGISCINLPGWVKGFGLNILQKVLEIYKPTDIVYLESPSTVRHFSELRIPKSFSSTMMTEYSPRSYRIPAEFSNAAINNSPEIKFAPSDIRTYKLLCLFHRSDTSNVPTFDFRPLIAKSPKKISYGRAGIHTIIINIEFALVPSHELIQALEGTIVAIYHEENTDDEHDSSSDIRVLSNDDLETAKFITLGLVHSVDEERKYFNIYVPENMVATLKNLGNRFMIERLSTETPFCELSPPNKVLKTDQTSPFISFKTRKKYEHVWKIRKNIKRKGHHL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Miscellaneous:
MISCELLANEOUS: Present with 6900 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MSLRILAKRSSSIWMKTRVTPALISPITITTRFNSTTTTAPSHKDDVRPVDPKISKIVQDISQLTLLETSSLINELKTVLNIPEISMPMGGFMAGAAGAGAGNVPSSTGEAGSGAEEEAKPEAKTVFTVKLDSFDTKTKAKVIKEVKGLLGLSLVEAKKFVEAAPKVLKENVAKDDAEKIKKTLEDLGAKVSLE
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLTRYQIRNEYALADPDLYKAADKDDPEALLEGVAMAGLVGVLRQLGDLAEFAAEVFHDLHEEVISTSARGHSLMIRVQQLEAEVPSIEKAFLSQTNHTSFFTSTGLDWHPNLQSEQSHVARGDLPRFVMDSYEECRGPPRLFLLDKFDVAGAGACLKRYTDPSVFKVERSNIEPQREKKTRKVKKKGPRWRNGGTPEIGPASHTKLHQLFMEERIESCFNDPSRLVKLKKRQFNGCIDSKNGKSYMEKFLETPSPEHKMVYEASVAAPTLHSMSDNTNDLGLRILDITTVSPASKSPGRGSTCSSCLAHEEELKRPINGDVSGDEIFKMPESTADDEIETTSNLQMVVVENHLEYGEGKAGSSIDGYRSDEVISEVDNYVDALATMESEIETDNEPRSKTINLGRHRGESDANAECLETQAQLSDSQSFVNSSGSDNGISSFKRERSSFSCSDTLSSLVDNIQFDTEETAKVLPSISKACMVDIENMPCNTDYTSLSHENHADENGVLDDTSVDEERKSKSEVSEDSRFLDSISPQPRSDPESCSSPSLLVKPKLYKTSSTDLVNSLQTSSTEIDLDCDEDVHLDVPSKAVSSANHTIPSEGIKDRKGVDVDATSENSLHFPNVLWQAVEIQAVEKVEDTMRQKEYQDDRTIDKQEIESSPSSLLPSETSCVSTNDSSDNKYDAIALKGDDNVVIAEAKCENSSLAVDLLQTQDLKDDNIVAGTKYEDLPLAADFSKTQDLKDQVKNAADDVLLFEGDTTETDVTYSVRDPNVVDITRADDDGKVTIFTHTDDTSEEKQLCYPNDTVREHLNSRDLVETVNHEGVTLSSTSVSSHDEITSPGDLDHEASVNYSNFATGKVQANEVVDSGNYSDIVTEKVQADKVVDSVACSDIGTEKVRSEKVVDFVNYSDIMADKVRADETVVQGAEVIPKNLSQSGDEENISIDKLPTGAHEAHGFAFNADRTTSNDMNGIVGTSLNDILSTSDNIRSDLSENHLALENSSDLLENHLGLENSYPNQNGFKDASDYSGDKVNHREVASAPLESKDGSISDHQDSVKDVLSFGPKYLELRNLESNPRSYHQGDLKEGIELISPPPLCVSSAIETSSRPSPDLQAKHKEMELMQADIDVSTSALIGQRSTSQLDEEKVEVAQSSDPFQQDQSFKGKADGVTIEAGHSLSELYKQHPIGEHNVTGRTTNTLQPVLPSNYMLLPEVPQVSLNEMPPLPPLPPMQWRLGKIQQAFPAPPRSDDPLQSILPSSITPPLQPENPYTFFQDNNLMNISGNMVHNTMQPPPFSLQSSVISNENFQYSSAIMEKQYNNPFLNLPPMARETPKHDSLKSDEQELHSDPKLPSLEPTNDDANCNNDNESSYLQSFQPFSYSASEVVLKPQDFEGGQRTSHAMMVPPSLMKNEQSRDDLPNTEEEVASSSNTAPMPSTYGVDMPNGNLPISSKLLRPRSPLIDAVAAHDKSKLRKVSDRILPEMGPKVDERDSLLAQIRTKSFSLKPAAVTRPSIQGPKTNLRVAAILEKANAIRQAFAGSDDEDDNSDSWSDSE
The following text describes a protein:
Function:
Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKGLFCRAEIRVREKLNRIDLNICERMATTKLLNFNVGVLGHVDSGKTSLAKALSTTASTAAFDKNPQSKERGITLDLGFSSFSVDVPDHIPASDYDKLQFTLVDCPGHASLIKTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACEKMFVVLNKVDMLPPEKKKQQIEKMTKRMLKTLESTKFANCPVIPVAAKPGGPDAPEEGAEGIQTLIEELKRQTYVPKRDSSGPLLYSVDHCFGIRGQGTVMTGTVLSGKINIGDNVEVPSLQITRKVKSMQMFRKPVNSAIQGDRVALCVTQFDPKLLERGLVCAPGILPIISAAIVSVHRIPYFKGTCATKAKFHVTMGHETVMGKVSFFGPAPGHQYQPHAQASEFNFEPEYLYEEELHTVDSTGKQEHNKENIPGATSEGEKETLPTQQWALLEFEKPVACPRNCLIIGSKLDTDIHTNTCRLAFHGKLLHAITDKNYVETVLPQLKIYKTKLREGLIDRMTDEYSVIGRSLFKKETNLQTFTNLKVQLSTGEEGVIEGGFGQSGKFKVRIPNGLQSETVQMLSALGGKKKGKKAKAESVPEPSAAKESHEEHQPIKISLRFKRYIYDTKKQMIQK
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLKNLSKGFPSLINKRSFSTINENPLTRIHHGSRTQTTGLVATVFGATGFTGRYLVQLLARTGIQVVVPYRCEDEGFRDLKVLGELGQIIPVRFDIRDSESIERAISHSNIVINMAGRDYETRNFSLDDINVHAASRIADLSKNVEKYIHVSTLRASEDSPSHFSRSKAIGEKLTREIIPNCTVVRPSIIFGDEDKFINKWSKVSQNWPFIPRYNQQHKIQPLHCYDLASGILSILETPGTSGKVYEFAGDEVFTWDEFLDMIIDGTAQYSKLNIPVSNDFMKFISEHLLERFARNPNFIKDQIDYHNQDMTTTVGALTLKDLNVTTTPIQEKLIRLSRMYRPGKFFNAIANPQNK
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MPCQVSWSEAESLLSSAVKSGATTHTMFHSVTALNNLGKPVPKDVLNLLTEALKTEDSPFAYANVFYTASLLTGDLKKVHDLIEDIVAQADEINEEYLQFESGLRPTASVIYSSHLLSVVANLKPAIADDKIIKFANYLLARKHTTSIIDASLVICAVHSIATSKFYTPIAVALTSSVSVSDKSPVISVKVVDLLGGAVEKLTVVAETARHITDNAVILSKKTLTPSKTDVTQHELDLYQLKPAIGFYRIVLSATSAREDVKLLGNQDAEVKVKVITRMAIKNVEVLIQDREQGTVLKSHKLVQPNKVTLEADYHQKFVVKFSIVDSATDKFLHAHQTFVRLLNQKTNHEVIYVAEEDGQETYKFDLNIGLKGKDFNGLSGRYLVDLIVGDAIIENPLSWTLADVKLTFSDDATPPASDPYLYSAKPEIKHMFREPEKRPPSTVSAFFTGLVLLPVLILLVLWIMIGVNVSNFPLSLFALMFHIGIGAIFVLYGLYFLRLNMFETLKYLSIIGLPTFICGHRTLSSIAARRK
The following text describes a protein:
Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLQASYGTAPSTRNEALQQVIDRDENGHFCAVYDFALCATTEVGVSPCGKCLAYPNSACRVVRERWLCAFCGSWNAAAGVGARRRGAHYAVGLGTSPAAAQLVFVVDLTMEAAELQALKTHVAALVGSVSGRFGLVTLTDGAVTVCGGRGRAAAVPTDEYRKFQLERLDPQPLLKRHLGEMSELWLTAEELLVAVGALEAQPCGAAQEERPRRGTGIAFFVAALFNMHRVGFALKVLAFLAGPCTQGPGKVVSKSYRNHMRGHSELQNRKARYSSQAADYYRSLREFAPAVSYDVFITSLDQTGVWEMAQCLNHVVQYDTLVEDRFHLDMHAYARRLRNEIVPHQVNLITSDTVLVDGCFGPVRKLPPLRNNYSDTERGVGSTTTWAYNGTLLSADELSLCFSLCLAPSVRQSSKESAAPNITLQVEFMYEVHGELCVAVTTLVLPTTSDPAALSLPQSFNATICCVSFMKRIAWEILNGHWHSYKLHDWCTALDDLCVRHLDSGSFNASQLVQLSYYLQRSALLRLAQTSPDEWAVYLLAILRRDSTQCLHICRPLITMLTPERQQLRLNPDVLRDVRPMVVDASNYVIVRYSDPNDSALHAVRAMAQQLQLSRWPVPWYKDTPIGKSQDRYVLSRLGVSTASNLPSSEVSLDAYITYIHSKL
The following text describes a protein:
Function:
Translocates preferentially neutral amino acids from the vacuole to the cytoplasm.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MGFQNEASSSSYTLKIPPPAREDSPLLGKGPPLSSQFKTFANVFIAVVGAGVLGLPYAFKRTGWLMGVLLLVSVSVLTHHCMMLLVYTRRKLDSFNAGISKIGSFGDLGFAVCGSLGRIVVDLFIILSQAGFCVGYLIFIGTTLANLSDPESPTSLRHQFTRLGSEFLGVSSKSLYIWGCFPFQLGLNSIKTLTHLAPLSIFADIVDLGAMAVVIVEDSMIILKQRPDVVAFGGMSLFLYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISLIYIAFGILGYLAFGEDTMDIITANLGAGLVSTVVQLGLCINLFFTFPLMMNPVFEIVERRFSRGMYSAWLRWVLVLAVTLVALFVPNFADFLSLVGSSTCCVLGFVLPALFHLLVFKEEMGWLQWSSDTAIVVLGVVLAVSGTWSSLSEIFSVKV
The following text describes a protein:
Function:
Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.
Subcellular Localization:
Periplasm.
Sequence:
MTTKIFKRIIVFAVIALSSGNILAQSSSITRKDFDHINLEYSGLEKVNKAVAAGNYDDAAKALLAYYREKSKAREPDFSNAEKPADIRQPIDKVTREMADKALVHQFQPHKGYGYFDYGKDINWQMWPVKDNEVRWQLHRVKWWQAMALVYHATGDEKYAREWVYQYSDWARKNPLGLSQDNDKFVWRPLEVSDRVQSLPPTFSLFVNSPAFTPAFLMEFLNSYHQQADYLSTHYAEQGNHRLFEAQRNLFAGVSFPEFKDSPRWRQTGISVLNTEIKKQVYADGMQFELSPIYHVAAIDIFLKAYGSAKRVNLEKEFPQSYVQTVENMIMALISISLPDYNTPMFGDSWITDKNFRMAQFASWARVFPANQAIKYFATDGKQGKAPNFLSKALSNAGFYTFRSGWDKNATVMVLKASPPGEFHAQPDNGTFELFIKGRNFTPDAGVFVYSGDEAIMKLRNWYRQTRIHSTLTLDNQNMVITKARQNKWETGNNLDVLTYTNPSYPNLDHQRSVLFINKKYFLVIDRAIGEATGNLGVHWQLKEDSNPVFDKTKNRVYTTYRDGNNLMIQSLNADRTSLNEEEGKVSYVYNKELKRPAFVFEKPKKNAGTQNFVSIVYPYDGQKAPEISIRENKGNDFEKGKLNLTLTINGKQQLVLVP
The following text describes a protein:
Function:
Involved in the biosynthesis of terminal alkyne-containing amino acids such as L-beta-ethynylserine, that are produced as antibiotics by S.cattleya. Catalyzes the hydroxylation of the dipeptide L-gamma-glutamyl-L-propargylglycine, leading to L-gamma-glutamyl-L-beta-ethynylserine. Cannot use L-propargylglycine as substrate.
Sequence:
MSGTTHHHATFPAVEAAAFTRRHLDDLAAGLLGTVRVPGFFGRPALDTMLTSLHRVPVVSFDLDRMHHPMARFGTALNDYRTPELALDADRYWHDADTARRQWAGIGMTPDPLELALDALGRAWGVRPAPATIGGRPAFVGMLREVNDGTFIHYDDINREYRGGLFDQKIVAQLAFNAWLAAPREGGTTTVWRHRWEPADENRRHGYGFQPTAVADDPYVTVAPAAGDALLFNANNYHVVHPGAPGQRRIALACFLGVTAGGELVVWS
The following text describes a protein:
Function:
Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell surface. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane. Melanosome. Membrane; Multi-pass membrane protein. Secreted.
Sequence:
MAMEGAANCIKYMVFLFNFIFFLGGVGLMGVGIYVQLKIGDYVELQSVKYITGSIIIIAVGAFIALVSFFGCCGAIKEHRCLLATFFALLFIILAVEITGTALGYVYRNKVEEQLGKDMNDTIVSYGEKGKEGITDAYDAIQKKEKCCGINGFKDWQRSYYTKGNHSIVPDSCCKTVSKGCGINFKENDIYTKGCFDTVKTLLKDNLIIIGGIGIGVAVIQILAMIFAMVLVCKIGAQSEYA
The following text describes a protein:
Function:
Plays an important role in the regulation of rRNA transcription. Binds to rDNA promoter fragments.
Subcellular Localization:
Nucleus.
Sequence:
MATKTQLELFTKLTSNDKAIRLSSAAQLIDSLSNEEELKYSLNRLTKGLSSGRESARIGFAVALTELLTRTKDIRATHVLDLLVKHNTASGNLKGQDERDFYFGLLFGLQSIVYSGILTHKESTIEDFQRVVDLLLQLSGKKNWLQDVCFYVIYKLVEQIPEISFSSNAFLAVNKLLQTPAVSKSTEGVGLFLCLTRVPDNVKSEEVAMANWEPAHPLHKSNLVTLSKIMRQADASETGGQNSAWKQKIPMVWKYIFEEYQRKTYSGLAPFHDFWAVVVDEGIFSSTSSLERKFWGFQIMELALDYVSSDNIGDIFSKNFLHCLINHLSDEDRYLYRAAKRVTSKLEKVSKQNPTLVYPIAIHLLGERGSLNFDRVTNTKLVEHILPLADEQGILQLFQLLLSYVKRCPEDIASDTKAVEWRRQWATDTMLSILRSKRSIKQEPWVRELLEIFIAYGYFEVPESEEVIPKFSEGTQNMFRLRLMSALSYLSSSAFQQSQTDHQLGDKNWPYVALNYLLELEKSPKNNLLISMDESVIEIVQKSLSVLHKVTKKIDKKAQHLQQLNAFQLLYSLVLLQVYAGDTDSIDVLEDIDNCYSKVFNKKSKRESTSNEPTAMEILTEVMLSLLSRPSLLLRKLVDMLFTSFSEDMNRESIHLICDVLKAKESVKDSEGMFAGEEVEEDAFGETEMDEDDFEEIDTDEIEEQSDWEMISNQDASDNEELERKLDKVLEDADAKVKDEESSEEELMNDEQMLALDEKLAEVFRERKKASNKEKKKNAQETKQQIVQFKVKVIDLIDNYYKTQPNNGLGFEFLIPLLEMILKTKHKVLEEKGQAVFRNRLSKLKWTEEKPSSKNVLEALKKVHVLCGKKASLGSTGSSISQLLLKLLADTPYLKEGVEVYLKSFLLWIQEPSKSHYNANIFHDFINWGAQQRLKHQQTSTAASSPQKTGHHENEKTNH
The following text describes a protein:
Function:
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier. Activates at more negative voltages, exhibits fast prepulse-independent activation kinetics and deactivates much more slowly, but shows no inactivation.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLGNAQVHRGFPIVYCSDGFCELTGFARTEVMQKTCSCRFLHGAETSEHMSQQMEKALESRQEYQVEVRFYKKNGTPFWCQLDIVPIKNEKGEVVLFLFSFKDITETRGKGHHSGRKEGTEEKRRNKKSGSSHFTAARKRGHAVLFHLTSQFSKKSKSEVTLNNRGGKGDADLYFHIHSHFLRVFLQNVFENKPSVPEYKVATVQKSRFILLHYSMFKALWDWMILLATFYVAVTVPYNVCFTAYDDSDSASRSTIVSDIVVEMLFILDIILNFRTTYVSQSGQVVYDARSICIHYAATWFFVDLIAALPFDLLYAFNITVTSLVHLLKTVRLLRLLRLLQKLDRYSQYSAMVLTLLMSMFALLAHWMACIWYVIGRKEMEHHDITTWDIGWLHELGKRLETPYINSTLGGPSIRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHTRMKDLKDFIRVHRLPQQLKQRMLEYFQTTWSVNNGIDANELLHDFPDELRADIAMHLNKDILQLPLFESASRGCLRSLSLHIKTSFCAPGEYLIRHGDALQANYFVCSGSLEVLKDNMVLAILGKGDLIGADLPGQEQVIKTNADVKALTYCDLQYISLRALREVLELYPEYASKFTADIHHNLTYNLREGSKAEGLSRFARSPRLSQNRLENISTSDHKLPLIVEDEDEPEEYFHLSPATKSRRKLMLPSLSSPVRRGSLGNLLGDELRQFSALRRCRSPVRGSRGRSPSPQHQREEPQCAAPSAEACASRKPAKLLIPSLNCFGPPDLSPRVVDGIEDNGRTSEAHTFHFNVQHGEAKASEESFVKEASPVSATLLLETEEVRQSISRLNQEMSHLNQEVSQLTKELHHMMHFLQAHMAVQHYTSALSSYPYGVQMVSNPPSSSSIGVSEWQPRVSYNLAAGMHMHHEPVNMEPLSHGKPWSYSGAPGGRGSTMDAGRTMNPGAEGKQNLCQPSGSTTAPQQPQNCPSLLNPSGVFAGFATAPQAGYSGASPHSGQQLRSSVNLSQSHPTLCQPAPPNPEYNYSKSNTPTPVHSALITPSSGPKHEQFACLSLSPRQNDPVGSSPLHVLEVGSLEIRGPIPSASAPSQNSRKPSLGSQDSNVSGTETSDSGHPLCDTGSADHIGLECLSTKSGATEGIDMEASESRRSSIGTQTQDNEVFWSLEMAD
The following text describes a protein:
Function:
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MMLCSLSGQVPMEPVASLKSGLVFEKRLLLKYLAQNQQRCPVTGEQLDADKDLLALRPTPSATKAQAGASTVAPEAASIPQLLSAFQNEWDAVMLETFTLKQHLEQTRQELSHALYQHDAACRVIARLNAENATLKERAVAPEQDDVDMGAGQDGAALAPEVLATVEAKQKELAKKRKEFKKKDAPLRAARLSGLDTWKVASSHTLHDSDKPGVTCVAVDCKRPTLVATGGVDKHAKVFDTDKQQLVATLTGHAKKLSHVEFHPTADMVLTASHDKTLKLWTPQDEGYSVGYTLDGFDDAVASASIHPTGNYVLSGSLDATWAIHDVRRGQLLSRYTLNGELAMPEVTSGKPKKAANEARCARFHPDGGIFGTAAKSKLVQMWAVNSLSNVVTFEGHAAPVTALGFSENGYHLASGSEDGVVKLWDLRKATSFFELDLKKEQPKLKLGAIHSVNFDASGSHLAVASAQTVQVLKEVSKNQWEVVKTLSDHKAAVTGAQFAPDSSFLASTSMDRSLKIYR
The following text describes a protein:
Function:
Deubiquitinase involved in innate antiviral immunity by mediating 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization.
Subcellular Localization:
Cytoplasm, perinuclear region. Note=Localizes to perinuclear region in response to herpes simplex virus-1 (HSV-1) infection.
Sequence:
MISLKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKFIRIFQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFLFIDKLSYRDAKQLNMFLDIIHQNKSQQPMKSDDDWSVFESRNMLKEIDKTSFYSICNKPSYQKMPLFMSKSPTHVKKGILENQGGKGQNTLSSDVQTNEDILKEDNPVPNKKYKTDSLKYIQSNRKNPSSLEDLEKDRDLKLGPSFNTNCNGNPNLDETVLATQTLNAKNGLTSPLEPEHSQGDPRCNKAQVPLDSHSQQLQQGFPNLGNTCYMNAVLQSLFAIPSFADDLLTQGVPWEYIPFEALIMTLTQLLALKDFCSTKIKRELLGNVKKVISAVAEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKECGDENSSPQMHVGSAATKVFVCPVVANFEFELQLSLICKACGHAVLKVEPNNYLSINLHQETKPLPLSIQNSLDLFFKEEELEYNCQMCKQKSCVARHTFSRLSRVLIIHLKRYSFNNAWLLVKNNEQVYIPKSLSLSSYCNESTKPPLPLSSSAPVGKCEVLEVSQEMISEINSPLTPSMKLTSESSDSLVLPVEPDKNADLQRFQRDCGDASQEQHQRDLENGSALESELVHFRDRAIGEKELPVADSLMDQGDISLPVMYEDGGKLISSPDTRLVEVHLQEVPQHPELQKYEKTNTFVEFNFDSVTESTNGFYDCKENRIPEGSQGMAEQLQQCIEESIIDEFLQQAPPPGVRKLDAQEHTEETLNQSTELRLQKADLNHLGALGSDNPGNKNILDAENTRGEAKELTRNVKMGDPLQAYRLISVVSHIGSSPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEARLHSGYIFFYMHNGIFEELLRKAENSRLPSTQAGVIPQGEYEGDSLYRPA
The following text describes a protein:
Function:
Snake venom VEGFs may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. This protein activates the vascular endothelial growth factor receptor-1 (VEGFR-1/FLT1), and consequently promotes the proliferation and tissue factor production of endothelial cells, the neovascularization in the chicken chorioallantoic membrane, and increases vascular permeability. Also stimulates tissue-factor production and human monocyte chemotaxis.
Subcellular Localization:
Secreted.
Sequence:
MAVYLLAVAILFCIQGWPSGTVQGEVMPFMEVYDRSACQTREMLVPILKEYPNEVSHLFKPSCVPVLRCGGCCSDESLTCTATGKRSVGREVMRVDPHKGTSKIEVMQFKEHTACECRPRSPGDVNDGRNPKEGEPRARFPFV
The following text describes a protein:
Function:
Regulates the coordinate transcription of structural MAL6S (maltase) and MAL6T (maltose permease) genes.
Subcellular Localization:
Nucleus.
Sequence:
MGIAKQSCDCCRVRRVKCDRNKPCNRCIQRNLNCTYLQPLKKRGPKSIRAGSLKKIAEVQMVSMNNNIMAAPVVCKKVPKNLIDQCLRLRLYHDNLYVIWPMLSYDDLHKLLEEKYDDRCAYWFLVSLSAATLSDLQIEIEYEEGVTFTGEQLCTLCMLSRQFFDDLSNSDIFRIMTYYCLHRCYAQFADTRTSYRLSCEAVGLIIKIAGFHREETYEFLPFGEQQLRRKVYYLLLMTERFYAVYIKCVTSLDATIAPPLPEVVTDPRLSLESFLEVIRVFTIPGKCFYDALATNCVDDSCTEDSLKRIRNELHTTSLDIEPWSYGYIDFLFSRHWVRTLAWKLVLHMKGMRMNFLSNTNNTHIPVEIARDMLGDTFLTPKNLYDVHGPGIPMKALEIANALVDVVNKYDHNMKLEAWNVLYDVSKFVFSLKHCNNKMFDRFSTKCQGALITLPISKPLQLNDNSKDEDDIIP
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm.
Sequence:
MTVTNEQFLSELTKLFEESTSKHSVYVSSKKAPASAAKDDDVDMTPSSSCGLTDAILFRATNGVSGSGKVKISTLVPASKLASFQGAYLPLLRTHLSNGLKKRDKARERKMDKAREQSRKKLIETVDGRDKIITNKMGSKRGAGRRKRQRALKKGLALRKEKSKEAKRKVQAAKTA
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Sequence:
MSKPNVLLFGLGGIGGIYASILQLSGKCNVHVVARSNYQKVRNQGFKIISPKFGNHDGMKFAGVWKSTDEAAASGAEFSYVLCANKALLDAKPSLPDHLRPIISPATSIVLLQNGVGAEVPLHEAFPNNTIISAVVWTGGKTLPDNEGVEQFNREGLTIGVDYREGGDRKEEDEKLETLVGLLEAGGGDCIVTKDIQSERWVKVIWNCCWNTLTASTLLKTGPFFQSSDLALPLCYSIMNEVVAVAKAKGLTVPDGTTEKLIKQCTDVPYPGLPSSMMADVKAQRPTEVEVILGTPVREGIRLGVPVPTITTLYTLIKAIDYRNQNPDAANA