lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers.
Sequence:
MMDREQDQRPKDSPVELRQMQYFLCLAEEKNVTRAARQLNIVQPALSMQIAKLEAELGQKLFDRSVRGMTLTSAGEALVRLTAPIVRDAEYARQEMAQLGGRISGRVSVGLITSVAQSTMARSSATVASRYPEITLSVCEGYTETLVDWVNTGQLDFALINVPRRRTPLAAHHVMDEEMVFACRKDGPIKPPARLRFDHIANVDLVLPSKRHGLRLILDEHAAAVGIDLRPRLELDTLPALCDVIATTDFATVLPTIALRQSLASGAIRAHRFNEQRIVRSIAWVHHPRRTVSVAAKAVLDVISRDLAQAAAVAKEFVEPTSGGTSSSSRKRRRTPRRKTIS
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has antibacterial activity against the Gram-positive bacteria B.megaterium and S.warneri. After a 45-minute treatment with this protein, B.megaterium have no visible pili and are smooth. Has no antibacterial activity against the Gram-positive bacteria B.thuringiensis, S.aureus, S.clavuligerus and B.anthracis, or the Gram-negative bacteria E.coli and A.tumefaciens. Has no hemolytic activity. Does not inhibit the proteinases elastase and cathepsin G. Is not toxic to mice.
Miscellaneous:
MISCELLANEOUS: A D-omwaprin has been synthesized to permit cristallization by using a racemic mixture containing equal amounts of L- and D-omwaprin. This D-omwaprin provokes B.megaterium lysis (after 45 minutes of treatment), but fails to inhibit growth of B.anthracis.
Subcellular Localization:
Secreted.
Sequence:
KDRPKKPGLCPPRPQKPCVKECKNDDSCPGQQKCCNYGCKDECRDPIFVG
The following text describes a protein:
Function:
May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity).
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
Sequence:
MSLFFLWLVTYYVGTLGTHTEIKRVAEEKVTLPCHHQLGLPEKDTLDIEWLLTDNEGNQKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGEPTEGSDLTLQCESASGTKPIVYYWQRIREKEGEDEHLPPKSRIDYNNPGRVLLQNLTMASSGLYQCTAGNEAGKESCVVRVTVQYVQSIGMVAGAVTGIVAGALLIFLLIWLLIRRKSKERYEEEDRPNEIREDAEAPRARLVKPSSSSSGSRSSRSGSSSTRSTGNSASRSQRTLSSEAAPQPGLATQAYSLIGPEVRGSEPKKAHHTTLTKAETTLSTMPSQSRAFQTV
The following text describes a protein:
Function:
Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MVGRGSFSSTSSASSINWIPKNTKTSIESVSNTISLSENGQNQDLETVTTKESNVGDSDTTENIKSPFNGQWPFSRRSSQSSSHPVFEETHWSKHSKRPGKLNVLTPTSPSNVNAEVQSISTKTQLSLLNLSPHKHKKPKDGLDLSALQKTLNGSRNFLRGRRDAGGIFGASIPQSLVTNQIINGFGAASLAFAKLGKVRSPLEGRFNLVPISADETWLIVESEVCSLYSGEALHYSLEDLNGILILHLQALIRDTKMNEFVGHLETLFRKATKCLSDSLSPVPEELFLNRIIETWLFFFSSVLPYVQGVFLPIKTKLFDEQEKTQLPYEVNEFCSTNREKLNVHRLALMTFRDYMVLPIANRIQICIGRAESAENALDNAGEVFARLFQILSLLASVRTNDSKEQEITNLATKVRCLLIAS
The following text describes a protein:
Function:
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids.
Sequence:
MLKQKALVDVLGQVNTSGVDGSWLFNKEGLLLAYVGSEQKAVASNVSSALIASVWAALERRANDLKETILVLENGVIGCTLVARTMLLAVKADKSADLGMVRAKLHTLAAYLEQPILSISHDLG
The following text describes a protein:
Function:
Positive regulator of basal resistance.
Subcellular Localization:
Cytoplasm.
Sequence:
MVDMDWKRKMVSSDLPNSPKLSSKLHVTIPSPFKIVPVSSPISCSAPALCSAYELYLRLPELRKLWSSRDFPQWTSEPILKPALQALEISFRLVFAVCSDTRPYINHREWNRRLDSLITKQIQLVAAICEDEEEEGISAEAPVGGGRSSLSLLPQLATWRRSEALGKKILYTIDNEMSRCKYTLGLGEQNIAGKPNLRYDAICRPNEIYSLKDNPYADHIDNHENQTLYIIHQILESWIYASGNLLNRIVSSIEEEKFGKASNDVYLLEKIWKILAEIEDLHMLMDPEDFLKLKKQLQIKSTGKNDAFCFRSKGLVEMMKMSKDLRQKVPAVLAVEVDPTGGPRLQEAAMKLYARKTECDKIHLLQGMQAVEAAAKSFFFGYRQLVAAMMGSAEMNATASQESCDSLSQIFMEPTYFPSLDAAKTFLGEFWSHLG
The following text describes a protein:
Function:
Neurotrophin which may function as a ligand for the Toll-related receptors Toll-7 and Tollo. Binds to Toll-7 and probably acts as its ligand in promoting motor axon targeting and neuronal survival in the central nervous system (CNS). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons. In larvae, involved in the negative regulation of the tracheal immune response to bacterial infection perhaps by acting as a ligand for the Toll-related receptor Tollo. May be involved in the normal development of specific neurons at the neuromuscular junction.
Miscellaneous:
MISCELLANEOUS: 'Spaetzle' means 'noodles' in German.
Sequence:
MKAGRAFGCLFWALLYCVLYLDLVSGNSADDELMDFDFADSNDAAMEDWQLDDLEEAKKAEQAEKKLESNMLDFSVDLDEPEPEKQLPPFDWRERVLRNALAKALADEGLRQKFAEVLPILRMLSSQQRLALSALISAQMNAKKGHELKFEQVRMMFGNEKKLLLPIVFDIANLIKSSTRKYINLGSDLASSALYHTPINRREDDLTPEESQQDDQLGTIAVEVEPKKVSTEEVQLESLEDFFDEMGSEVLDPQMINEALTGDLHDNKTKTFKPENHGQRVRRSANEFVHKLTRSVPASVTEQQLLGGIAGRTIKLNTTAFQQPSSQEEEKMASSNGGQSYSEVEDLAFAGLNGTEIPLSADERLDLQRNSAEETEEPLPSPEELIAGPRYRLGKRPLPGQKSGSPIKRKRVTSSLRGRPKTAASSHKPVVTPPNKKCERFTSNMCIRTDDYPLEQIMGSIRRHKNAMSALLAEFYDKPNNNLEFSDDFDDFSLSKKRREDEGSAGGMCQSVVRYARPQKAKSASGEWKYIVNTGQHTQTLRLEKCSNPVESCSYLAQTYRSHCSQVYNYHRLLSWDKVRGLHVDIFKVPTCCSCQVDGYRQQFPPLSSIQAKDYSPQSPVINHSHNGYSTINEEDLDYAEESEEDELGLRYPSFNNRETNELYSSSNKVRVKLPGISSSVGPYLSPPDDDEDRYGGYKSSSSSSKKYYSQVSRRRPQHSEARLDLDLAPSETHSDQEPPPPQHHQHHHLQYHRPQEELPSAYDFHRPQVYQPEREQLPLVRDPALSPVSAPVLASPAPPLPMPPMPIKQVPSHHQAHHQQPHHHLHQSTGKVAANRDPASMHHQPPRRPTQQWLPGQRRPFRPSAPLSGSGISRRHYHNRRQSIQ
The following text describes a protein:
Function:
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
Subcellular Localization:
Nucleus.
Domain:
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Sequence:
MQVIGRGGANILIDYGDPTWLWRCCIRWPDLLSSNNSYTIKNISYIKDYVEPLLHGLLCPMYLIDVDIEAIRPILSDFILNLDDKVVKVIKIKNLTNNTSNLILNNHFLKSYCSQNLQTVILELKPKWLYYDTDYCRNCTHNAFKGRGTKYCYNQLLMNPAHLELIFGECNIFPVKFKDAMHEYLRNDNNIFKILYDLQKKLTKNTTPISDIKSINDVNDEHLLLMTLRDVTCFIEWNSAENALHVNIIDVDLKPKEKWTHWTKTYSQLTSSQKIYHTSNK
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MLLKSSASFSLSSSASFIGDRKNAYSSTVLQFPWRNENVFGGKFVIKASKESGKASTLGAWFDPFEEVKKERLVVPTCPQDSLARLKFSSPCETAINEQINVEYNVSYAYHTLYAYFDRDNIALKGLAKFCKESSTEEREHAEKLMEYQNKRGGKVKLRVIVRPPSEFDNDEKGDALHAMELALALEKLTTQKLLDLHKVAVENDDPHLVDFIESEFLTEQVESIKKVAEYVAQLRRLGKGYGVWHFDQMLLNHGVAA
The following text describes a protein:
Function:
Regulates cell fate specification in the postembryonic mesodermal M lineage and body size, probably by positively modulating BMP-like Sma/Mab signaling at the ligand-receptor level. Promotes ventral fate specification in the M lineage, probably by positively modulating lin-12/Notch signaling.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Specifically localizes to the basolateral side of intestinal cells. Localizes to cytoplasmic vesicles in the M mesoblast.
Sequence:
MIDLKSIWNDKRKITYFFLANVCFLISGLSSLIVGVWLYSSKNNFIELTPTSYSALSAAGLCVFTGVTIFIIVAVGYLGVSWSNKSLLYSYIGFVILLILVHGIARITGSLHKEEAKENLRKSMLHNINTTAVVTKIGREIKLSLTWDHLQRELQCCGVDNYTDWHYSVHWPNNLYTPDSCCDPQHFDAENGTENCGKLPDEQSLLYQKGCFPKFSDWLYHHIILVNWVTSILFVVEILLLILSLVVLRVLKNSRHKTRRSHRERDPETTSENMRLNSMDRIADARLETDTVEDGMSINSR
The following text describes a protein:
Function:
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEYCTYEKYVFKKQLETLKSKNGRSTELISLYIPPDKQISDVTKHLREEHEQASNIISKLIRNNVQEALHSLLAKLRSLHKIPENGIVYFTGTVDTGANRTGMVNEVLFPPEPVADYIYRCDSVFYLEPLEEMLRECTTYGLLLLDLREATIGMLVGRQTEVIKHLHSTVPGKQRKGGQSAHRFEQLRRIAIHDFYKRIGDATSEAFLELDPAELKGILIGGHSPTKEEFNEGGFLHYELQKKVLGLFDTGYTDESGFSELINAAEETLQSIDLLKQKKDMEIFFKEIATESGKISYGEDNVRANLEIKAVDVLLLSEELRAERVTLKCRVCGYENKRTRKWKTGEAVPAIGHCPECDSELEVTDVIDTVGELSELADKGDARIAFISTDFDEGSQLMIAFGGIAAILRYNTGV
The following text describes a protein:
Function:
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
Sequence:
MPKVGMQPIRRQQLIEATMAAVNEVGMHEASIAQIAKRAGVSNGIISHYFRDKNGLLEATMRYLIRHLGEAVKQHLAALSVNDPRARLRAIAEGNFDDSQINSAAMKTWLAFWASSMHSPQLYRLQQVNNRRLYSNLCAEFKRCLPREQAQLAAKGMAGLIDGLWLRSALSGEHFNRQEALLIIHNYIEQQLNIKYKC
The following text describes a protein:
Function:
Methylates caffeoyl-CoA to feruloyl-CoA and 5-hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers.
Sequence:
MTSPSVNKNILQSPAFLKYILETSSYPNEHEQLKQLRETTEQKYQENMGYLLSIPAEEAQFISILHKILNAKKTLEIGVFSDYFLLATALALPLDDKITAIDMDREAYEIGLPFIQNAEVEHKIYFPVVMHYQPSMILLIVKNGKIKWSKFQDRQTESFGYVLVDTNKEEYIKYYELVSKLVKKGRLIAYDNTSWHGSVAISEDVKEDIIRKNRKPLIEFNNLIANDSRLESAIISIGDGLTLCRRL
The following text describes a protein:
Function:
Synthesizes cyclic GMP (cGMP) from GTP, after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MMFGNLPDVRKPKEGYKKYLEYFDLRFPRIQEEKHFQSYYYYTYLKQIRISIIFLTSVLFIGTMTAYISPLDISYLPYYDSKNIYYFNYVQPNVTTTSSSTTTTSSTTNSIDSTVENNNFTEADGHLTNYYFPYLANKARDTFILRMITIGLLLFYFIFTFTAKFKRLWKLFTTITLFLVSCIVLIFESDIRTIPGRMVLLFIIIAISSGMTFLPSMLASGGLCLFFFFYFMFYSQIAGKQMVLLSLVLLISWIILMIISRFKEQLFRDKFRTLENLKIQTIRSEKIINQMLPTVVVQRLRLQSSKDQSLETTLENDKELSIKKDEESNLTGKKQSKVVVSPPPPPTAAAPQQQDNEISTPQNSRKIVDPQSPSSLMPGQYSVTDLIVDSYDPVTVLFCEIVNFNALVEKMSSTQVINLLNEVYNSFDRLTDVYGVTKVEHIGNVYMVVGGCPELCPDHAQRVAHMSLGMLSVIRRFGIVQVRIGMHTGPVVGGIIGKKKLSWHLFGDTINTSSRMASHSSIGRIQVSHPVQQLLRPYFLFEDRGKIQVKGKGLMRTFYLVKTKQLDKRYTSIFSSLHREKPYIPPVDISEVSFENQNNTIGKGDDIASGSATGPTHPNIPNSMLSAIPSRVSIEMNPLGGSGSIQKRERKGSIFANVMPPKVLNFLQTGSLTSPQQQPLPQQSNSEETISNSPRLSSTPQSTSTLQHSSSTGALGSLINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLPVSLISPISQNTTPTGSLSLPVTEKKKQTVQFGSISRSSSISKGTVGRSPSPALFDGGIEMDDNGGGAGDDFNTMEPNLDLGKGIHGSNVISTNNSKLNKLEKDLTKHYTLDKFKLSFISRGNLVEKEYRNEYILKNWNRILASMLMIVALFGLSGLVDYFFLKLSSISSIVKVEPMPSSSSSSLSSSSSNSMTSSEEKFITLHTIRSEENLIYDIITGVRYGFVFFCLIVIYVVSKFKTFSIRKWIQEVVMVFFIVLAAVLIVLTSVPPLNKIPLDSVILSIEIMFITICYNFSGIKFWYSNIVCAFCIIFIEISKTWKQAYHSRDIYLSHNYYLITAVLINIITSYFEELFNRLNWVHGRLLDKDQRETESLVAEILPADIVKSMKSGRQLIVDEFKNVTIFLSDIVGFTEMAARMSPRQLVETLNQIYSTFDEIAQEFGVLKIATIGDAYFCVSGCPDKDQTDHAFRVANMAIKMLESIKSIRTVDNIPIRMRIGIHTGPVIAGVVGIKMIHYQLWGESVQITQQMESTSRADMIHVSEDTFNILKSKYLFEERPDGIIKKRKIKTYFLLRALTENDPQPEVKTRSVSVSKSNFGGSLQYNQITPTLNLPVSQLIIKDQNEIKNQNDHDNDDENGNENGNESSSSNINEEEEDDDNSNNNNNNEDDESSYEDDQEMNQYLNNSENNKNNNNNSNQINEEDGNWAKNYDGSSESS
The following text describes a protein:
Function:
Involved in the degradation of ectoine, which allows H.elongata to utilize ectoine as both a carbon and a nitrogen source for growth. Probably catalyzes the conversion of L-2,4-diaminobutyrate (DABA) to L-aspartate beta-semialdehyde (ASA) by transamination with 2-oxoglutarate.
Miscellaneous:
MISCELLANEOUS: DoeD and EctB both catalyze the same transamination reaction between L-aspartate 4-semialdehyde and L-2,4-diaminobutanoate coupled to the 2-oxoglutarate/L-glutamate pair. This reversible reaction is part of both, ectoine biosynthesis and ectoine degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MTTHKDLIDRDRKVTFHASTHLRDFAHGDAPGRVITGGKGIKIVDKDGREFIDGFAGLYCVNIGYGRSEVAEAIYQQALEMSYYHTYVGHSNEPQIALSEKILELAGPGMSKVYYGMSGSDANETQLKIVRYYNNVLGRPQKKKVISRMRGYHGSGIASGSLTGLKAFHDHFDLPIETIRHTEAPYYYHRAAEQEGMTEREFSKHCAAKLEEMILAEGPDTVAAFIGEPVLGTGGIVPPPEGYWDEIQAVLTKYDVLLIADEVVCGFGRTGSDFGSHHYGIKPDLITIAKGLTSAYQPLSGVIVGDRVWEVLEQGTGEYGPIGHGWTYSGHALGCAAGLANLAIIEREGLTANAAETGAYLQERMKAAFADHPVVGQVRGVGMMAALEFSVDPAARRHFDPSLKVGPRMSAAALEEDLIARAMPQGDILGFAPPLTTTREEVDEIVARTERAVNKVTDALTREGAIQAA
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDSFVLDAQNPNPKNLKNLLKYEEQLERQHVSLDNILGALDVRNHSLGQLLVLKAKGSDQGKNRSVFIDQCNNFFRNCNVEQVRLAPAQLSQLSKFYTEALYELKQPIRGVAVLKDALNILSDNKPTTTLTPIHTDFLQLCILSKCYHQALPLIESNITHINPEQSSIAIKDILCYFYYSGIIFTAFKKYKKAIEAFKFVITAPASALSAITVEAYKKYLIVYLIQFGSVQHFPKCTPAVVQRNIKSHCKPYTEFVQSFSNGNINDIMNKASSGAEFFQKDSNWGLVKLSIKSTYRRNIKKLTQTFMTLSINDIAEKVSLPKAKAEQFVLKMIEEGEIFATINQKDGMVTFDECFEDFSGPTILNDLDRNINNIVGLESKIKEMDEKISLSNNYLKKLASGKNTGQLSQYEDPMEDIS
The following text describes a protein:
Function:
Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVGKARSSNFTLSEKLDLLNLVKPYVKILEEHTNKNSVIVEKNRCWDVIAVNYNAIGVDRPPRTAQGLRSLYKRLKEYAKQELLQQKEAQSDYKSSISEPTKKVVEMIPQISSFCLVRDRNHIQSTNLDEAAQAGTSSLQVMVDHHPVAITVEVKQEEDIKPSPALVSSPQHNDALEQQEEHELMRVAEGSVSPSLSSVDMRMTSSPSSVPRRDVFHQESGEHLRSLLRCDPQVLQMLKEEHQLILENQKKFGLYVQEKRDGLKRRQRLEEELLRAKIEVEKLRASRLRRDLPEYSSF
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MNFNLNLEYLNSDPNSIIEYLTQIWKEDESLGYYKEFLDVCLKIVAGTDQPETFFKELTDKKLLNFGACETKWSFGDSAYKCRTCQLDPTSALCIACFKEGDHEGHDYALQSVGGGFCDCGDPAAFRPNGFCIKHKEQKIDINKYPERFILALSFVIQFMLKRIYVFYDKNNRVLFEMLIEWLLKLAQRGDIIKVVVIKYISNTDIGNTNLLPPSPFAVPLIQLFYSPDLHESVSRSMKETIANFCVFLRGSVEFIESFISLMLPIYKKCIIECKKHILLSSFSIFSSTAVGPLLLSTNAAEIVMDTITEYFSKHFYIRDEFISPSSSDSKSKKKRSLRFKDPYLYPQFKQLTKLHETPLATQVLRTDISFILGNQPVAKSVVESKHLLSLWINMIAIAQGMNPNVKYKITSPDDWSPAFNVDFSFSNTIFSIVNSISQDKLSLDQILLFSTQYLGKWILGWLEYRNNYQVEKLKRLEEKEKEEKEKEEKEKEIDSKELKTTTTTTTNTTQQQQQQQQQQQQQQQQQQQSIPHYLTNIKQLLSLHLKREGFSFHLPLHRLVSAILFKCLNNVELAKQYKDDGGLKSLFTQIIGSDSLISISDYARGTTYHPFKIIASLGEIKSGMWRSHGREEDMTLQTVVYQSLHYQKYFDLDIFLIQIGAAIMGSNQFIQHAINIYNLEDWFEIEPFNGSLNKSTEGTPTTTSSQPPSTPSKQTSLRNSAGTVPTTPSQSSSTIVPTLDTIGETTTTTTTTATTTTTTDGIITEPKKETKEEKKIRKEKQKIQEDLQKRKGLAEDFLQNVIMFSTNKLMCGMTEDQVIRKELIHRLCLGDNTHSQLTRAIKKKLVNHENFETILKEISVYHQPQKTEQGKYQLREQCWSEFDPYFSHYNTQDLQTAEERYSEFQSKTKSNIARGTYINYQTSPCFEEIDQLLCSKTLHQIVFTILQNQLVDGAKSTDTIFTHCLHALELCINQTLANPELKAEAISSAIVVQTPSKQTPLVKPSSATPPTSIPKNYSEIELPSKKNIFLNAFVDVPVSEQKRFSLIILLVKLTTSQQINADHKQQIQNIINILMENNVNCKQTIENYWAAIKAKKQPQSARKEDPEEEKKRLARARQAAILAQMKTQQSAFKFEDGEDDEDYEDDYEDASTKGSSASAAHKDKKQKQKESNALVVDGHESITTCALCREPGSLDRPMGRVAFIQPSSIIMLSKLTPEERKKRMTEAIMKELYQGVKGRETIISNNDNIINLNNNNNNNNNNNNVNNNNNNNNNNNNNNVNSINNNIGGIPIVNNGNDGGVNGLTDYIHPDMDEMDGDDMGDVDMGGMAVEDDGEDDSEDEVNKAISFLNRVSHSNDFMGGFGDFEDGMGMDIEGGDDDDDDDDDAEDDDMMMGELGGVRHHHHHHHGEEDEDGEEDEDGEEDEGSDSDSDLDLEDLNGSDDSDDEFDFGDEEGSDEYILEDGMPRLRRLAGTSTQQGTTSTNNTTATSTNDIAQTLLRALERIPTGTGNVNSRNIISQLTTQLSQGNARVHIQARDNNGRAFSEINFDQLLSQLNNQTNVPISVHDNGRNRASVTLQLNSTPPTTTTTTATSPATTTTTTTTTATAPKPNDNGGSDDEDSDDMGDIDGDDEDDLFGDDDDFFFDDDEANDDVFLKFDAATEPVTGKPWSNKFSKQEIFRNIEESVNLNLSFCGHQIHESCFSEYSWSLLKNNEGVEYVDPEKNEFLCVLCRRIGNAIVPVVPDSGFCSHEHTASPQPIITPAMARNNKNKDVQCYSEFYQALGNRLMGKDEEHKKALDAPNPQPLRNIRQAIDQFSSRVYGVRYDLNFYKSKSDATVIPFLCSSLASTIASTELSIRVHDPEQQQQQQQQQQQSSLYPLFSMSDSNRVDLRSLFRYMIVHSHMYPSLAYQGQLLWKSISGSQHTQLLPTEEELEEIERKENEEKEKLSKAKLDQKEKEKEREKEKEKNERERTQKLYPEVYDQGVYGEAFPPLLSLDLFNTFIQVFLRYSDTNLSLNVEKFYMVARMFYDASITQSILQHFKTTDTTFTTDDTYVSTINNLITTTYETVTPILSIPPVHLTAIKTNSLIFLRRLSIFLFSCLKIDPISSNQTTLDGEIDYLVDYLNLPSFDQHCLSVLNAITSHTENIVPLVSTWTEQILFISAITSSVEDSKNNVEDLSNNNNNNNNNNNNNNTTTTTTTTTTSPNDNQTVVSSPIKQSILPNPSIPNPFLLIQLPEQYNIVSQYYSSIPCLQCKTISNNQALCLVCGTLCCLGGCCKRFFDQKSEAVLHAEKCNAGTGIFLLIKTSSTLLIHLPRKTLWISPYLDDHGEEDPNLRRGRPLLLNANRYSQLNSLLVKHQIDQDSKIAEMSQR
The following text describes a protein:
Function:
Maternal RNA in oocytes remains in a dormant state as masking outcompetes eif4g to bind eif4e, thereby preventing translation. During oocyte maturation this complex dissolves and eif4g binds eif4e to allow translation of maternal RNAs. Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome (By similarity). Involved in microtubule assembly during M-phase. Involved in spindle pole assembly by recruiting and regulating ckap5 at the spindle pole leading to microtubule elongation.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle.
Sequence:
MSLQIINDENAGNDITAEKFDLLLNPQTTGRPSILRPSQKDNLPPKPALKSTKVTFQTPMRDPQTLRIMTPSVANKPENVFLLEDCTQALEQLHLSLPSSCGPNPVEINVSVSNNQPDSEELPVRTTGAYSIDFDNFDDINPFKSKTQMLNSPIKADLPSLTENIETTTPVVPADEASKQMVSLNLSAANLDSPVTVQFSSESGSIGVSEKTALDDTLPLSESGIKDLQGLNASSNNIEEPVPLDKDICSNNEKDDATMADSTCEGTSDAHTSSNNIEEPVTLDKDICSSNEKDNAAVADSTCEGTSDAQSPLPIPKSSYSFDPDQFDMMNPFKTGGSKLQNSPAGKKQTPPSADLNTAKTEPVKLEFNFGDGDVSERKPPPKKLGKRPLLKTAAKKPSPKPEIASEKQEQQTAKPSEDEAIVPKASYKFDWEKFDDPNFNPFGCGGSKISSSPKGQKIANEQPSACTQGSKPEAECTASDMAPAENADEKDHGEIEPSQDSGAAEDRSQAEDQSVALSKVEVPHEQTTDCSPVENETQPEVSLINEEPSQKEVEHTSSDMTPPEINGTDSEFKLATEADFLLAADMDFKPASEIFSEGFRQPVEIDYLENFGTNSFKESVLRKQSLYLKFDPLLRESPKKSAAGINLLPSVPLKCSSDLFGAIPEANFPLIPSIENEEKPKGLDLLGTFTVADTALLIVDAPSSVAVPNPFLSTSDAIVEMLKYSQKDMDAAIEAVRLEVQEKDLEVLEWKTKHEKLYLEYVEMGKIIAEFEGTITQILEDSQRQKETAKLELNKVLQEKQQVQVDLNSMETSFSELFKRLEKQKEALEGYRKNEEALKKCVEDYLVRIKKEEQRYQALKAHAEEKLNRANEEIAHVRSKAKSEATALQATLRKEQMKIQSLERSLEQKSKENDELTKICDDFILKMEKI
The following text describes a protein:
Function:
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.
Subcellular Localization:
Nucleus.
Sequence:
MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVPGATTTSSAATETMENVKKCKNFLSTLIKLASSGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFIQQSQQQPPPPTSQATTALTAVVLSSSVQRTAGKTAATVTSALQPPVLSLTQPTQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTPQQIQLNPLQPVPVVKPAVLPGTKALSAVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMAGVNLSEESARILATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKVDCPGPGSGAEGSGPGSVVPGSSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLYKAFLK
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
VLTSLLEWEAKEEGKEVTQQWEDDWDDDDVNDDFSLQLKRELESNTEKK
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTAIDVMWVGLGGGIGSLLRWWIGLSIGKVYKGNFPLGTFLINISGAFVIGYLSILFSVDWRDRYGDLMNTAVLTGILGGYTTFSSMQLDAAKLATARGRAIAAGYLIISVLVGLAAAAFGAWLAY
The following text describes a protein:
Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Sequence:
MVRRLCYMCALAVVILTGLMLWHETGTVRKINYTQKSKSPKSKALIQARKSIFGSSIAKVYDHVNTFVVFIGYPRSGHTLVSSLIDAHPHAIIANEFDIIGNWLAWNDEQRNKYFLFDQLYKNSRTEAKTGLRSSVKHMFNYSVKGQFQGKFKGSLKVIGAKKGGKLTKQLTKQKQADVMDQIMKTLNDTSALEREIVRYFDLVARNQILIRKYKHNLHEIQSTDLISKPRETLRRVCSFLNLTCSKKYLDDCAKIVYKRPSRTRYSVVWTDTQIRRTLSTLKRFAFLKNFTFTS
The following text describes a protein:
Function:
May be signaling molecules that resemble neuropeptides.
Subcellular Localization:
Secreted.
Sequence:
MRLLPEWLLLLFGPWLLRKAVCGQIVESGRPQYLDLRPAMAGGGARGQQLPAPASSEGLGMARSWSWAWPANHTGALAKPGTAGGPSVPRTKRKPSIKAARAKKIFGWGDFYFRVHTLKFSLLVTGKIVDHVNGTFSVYFRHNSSSLGNLSVSIVPPSKRVEFGGVWLPGPASHPLQSTLALEGVLPGLGPLWGWRGRGWGATLGAHLPAHSEAR
The following text describes a protein:
Function:
Plays a role in plasma membrane repair in a process involving annexins. Does not exhibit calcium-activated chloride channel (CaCC) activity.
Miscellaneous:
MISCELLANEOUS: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Colocalized with CALR/calreticulin. Shows an intracellular localization.
Sequence:
MVEQEGLTAKEIDYAFQQNENLGSKETSFLIPEDLQSPPEKRFNLFLRRRLMFQRSEHSKDSVFFRDGIRQIDFVLSYVEDLKKDGELKAERRREFEQNLRKTGLDLETEDKLNSEDGKTYFVKIHAPWEVLVTYAEVLGIKMPIKLSDIPRPKYPPLSYMLGAVKLPSSVKYPTPEYFTAQFSRHRQELFLIEDEATFFPSSTRNRIVYYILSRCPFGVEEGKKKIGIERLLNSNTYLSAYPLHDGQYWKPSKTTRPNERYNLCKNWARFSYFYKEQPFHLIRNYFGEKIGIYFVFLGYYTEMLLFAALVGLACFIYGLLSMENNRTSTEICDPDIGGQMIMCPLCDEVCDYWRLNTTCLHSKFSHLFDNESTVFFALFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHKKMNPVTKEMEPHMPLCHRIPWYFVSGTTVTFGMALLLSSMVSILIYRLSVFATFASFMESEATLQSVKSFFTPQLATALSGSCLNCIVILILNFFYEKISAWITKMEIPRTHQEYESSLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTTQLTIIMIGKQIFGNIHEAFQPLIFNWWRRRRARTHSEKLYSRWEQDHDLQVYGHRGLFYEYLETVIQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDILFGMAIVSVATNAFIVSFTSDIIPRLVYFYAYSTNSTEPLSGYVNNSLSVFLIADFPNHTVPMEKKDFVTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLFKFLLAWLIPDVPKDVVEKIKREKLMTIKIIHDFELNKLKENLDVEYGNIMKNVLVDEDNSLKAKTTV
The following text describes a protein:
Function:
Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. Involved in intracellular lipid transport.
Subcellular Localization:
Cytoplasm.
Domain:
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence:
MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNVSWWCSERVAPSA