lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Major extracellular chitinase, which is essential for chitin utilization.
Miscellaneous:
MISCELLANEOUS: Western blot and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses suggest that ChiA could be proteolytically processed into two GH18 domain-containing proteins. However, it could be the result of non-specific digestion.
Subcellular Localization:
Secreted. Note=Translocated across the cytoplasmic membrane via the Sec system, and across the outer membrane via the type IX secretion system (T9SS).
Domain:
The C-terminal region (CTD) is necessary and sufficient for secretion by the T9SS. The CTD may be cleaved during secretion.
Sequence:
MKHYYRLLFLLLFPLLASAQPAHGKKVVGYYAQWSIYARDFNVPKIDGSKLTHLNYSFYGTTYDPAHPENTKLKCLDTYADFEHMEGGIPWDAPVKGNFYDLMKLKQKYPHLKILISVGGWTKGQDLSPIAASPVARAALAADMANFIVTYPFIDGFDIDWEYPLSGGTDGTEIVNGMPVPPQKYSPDDNKNLVLLLKAMRQAMPNKLVTIAAGNNVRNVSKQYLGPNNRAQYGMTEDISTYCDYITYFGYDFGGNWYDKTCYNAPLYASGNPNDPLYGATQSESLDELTNQYLNVIGFPANKLIMGLPFYGKKFDNVAANSTNGLFVAAPRYIVPGCTNPQNPTGTWDGSGACEKSGSIEICDLVGNPVTNSHAYLDPNTMMVTPSAASAGWVRYFDNTTKVPYLYNSTLKQFISYEDKQSMDLKVQYIKSRNLAGGMIWELSQDTRGSIPNSLLNQVDTSFGSVVPGTVSISGSVKNGSALVTDVTVELRNASNAVIQTVVSANGNFAFNNLTSGQNYSLTALKATYTFTPVTLVNVTVNQTAVVINGTQPTYTVSGTVLDGSTPVSGVTVTAVSGSTTLTAVSNASGVYSIAGLTAGLNFTVTAAKSGFSYAPASTVYNAIDSNKTLNFTQGAPVVNYTVSGTVLNSTTPVSGVTVTASFTGGSYAAVTNASGTYSLSLPSGGNYTVTAALTGQTFTPASTVYSNLNANKTLNFTQDVVVSTSKISGTVKNGTNPVAGAKVELVLPWTDNTHNWKSVIATTDAQGKYSFDNSVVDGYTQVLSLKLNSWQNGEVAYYPNNLANFAVPANPTVYNFNTSSTAKSALAAAANLISGTVKNGTTPVAGAKVEIVLPWTDNTHNWKSVLATTDASGNYSFDNSVVAGYTQILSLKLNGWENGDVTYYPNNLANFAVPTTPTIYNFNRQAVVATKPVVTITAPTASAIAINLGSAINFVASVGLSAVDATTISSVVFSLDGQSLSTANSSGTYTAAWTPAANQFSLSHTLTVTATASNGTTDSKTYSFTLTCSGANCPNALPVITWNSPSNTTVYQNTFQVVPISVTAVDSDGTVSGVTITINGGTFNMTAGTNNTYTYNFTPSAYQDYPVVIKATDNKSGVTTLNNTIKIATVSTNRFIPLPSKIILGYAHSWENAGAPFLYFSQMVGSKFNVVDYSFVETVNRDGYTPILTTNDTRYLTNGVFNKQLLKNDIKSLRDSGVPVIVSIGGQNGHVVLDNVTQKNIFVNGLKAIIDEYQFDGVDIDFEGGSMNFNAGGLRDISYAGISAYPRLKNVVDAFKELKAYYGPGFLLTAAPETQYVQGGYTTYTDTFGSFLPIIQNLRNELDLLAVQLYNTGGENGLDGQYYGTAKKSNMVTALTDMVIKGYNIASTGMRFDGLPASKVLIALPACPSAAGSGYLTPTEGINAMHYLRTGTTFSGRTYTMQPGGPYPSLRGLMTWSVNWDASSCGNSSELSKAYAAYFASQTAAKTLVLDDISAKSNATIAYFKNNALSVTNENEDIAQVDVFNVLGQNLVSHRNVQNNKEVLLHNQSFSSKQLFLVVVTDKAGNKKSFKVMNFLN
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has a role in the activation of stress-induced mitophagy by protecting PINK1 from OMA1-mediated degradation and facilitating its accumulation at the outer mitochondrial membrane in response to depolarization.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MEGGGGSSNKSTGGLAGFFGAGGAGYSNADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGALNGLRLGLKETQSMPWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDFNTVAAGTMTGMLYKCTGGLRGIARGGLAGLTLTSVYALYNNWEHMKGSLLQQSL
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGRELQKRKKRSSRAKVQTHTIKKKVLNPQGSGIVAKAWNKKETLSQNYSRFGLVAKLGTAAGGMAKKSAAANYAGITKDDPLAVKSADRGLFEVREVKVERDASGKIVKVLRSDNPLNDPLNEIESDSESEEPKPKNPTHDIEWHGISDDRQEMIAQSSRPEVVRMLEEEASRPVEKTVRYQSERELEWLQRLVAKHGDDVAAMVRDIKLNPMQQTKGDITKRLRKAGLLQ
The following text describes a protein:
Function:
D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
Sequence:
MKFLLIASNKDLASKNIANHIKEYFDVFETDKELLSLTAEDLEYADYYIFLSKHKSIANKPSLTVHTPGNLTEDNTFGGNPKEVCPCDAVLNTLLLKNIYKNYKTYYEDGKIGEFDVSFEVVHHSPTGLKAPTVFVEIGSSEKEWILKEAGEIIAKSVLETIDAMKSKNYDKKVRAIGFGGGHYAPKFTKLALEDKYYFGYLVPKYASVSEDVLNQLISKMEVDKALIDWKGCRGDDKRRYIEFFENNGIEWERV
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSTPGDYYRSLPPVSKTYGVACLMTTAALYLGLYNHWTIALEYELVFKRFQVWRLITNFFFLGPFSFPFAFRLIIIAKYGVSLERGPFDKRTADYVWMFIFGALSLLVMAAIPPLYIPFMGPSLVFMIVYIWGREFPNARISIYGVVSLKGFYLPWALLALNLIFGNPLMPDILGMVAGHLYYFLTVLHPLAGGRNLLKTPRWANKVRLLILSAVMALYNTLGVNHVCVQSLNVRSHKVVAYWGEGFQVNAPVPSDPSAGIAFRGRSHRLGGMATRGRSPEQAQTRDQGPVQQPMPAAEGVAFRGRSYRLGGR
The following text describes a protein:
Function:
Immunity protein that plays a role in preventing early activation of toxin Tse6.
Sequence:
MTPIEYIDRALALVVDRLARYPGYEVLLSAEKQLQYIRSVLLDRSLDRSALHRLTLGSIAVKEFDETDPELSRALKDAYYVGIRTGRGLKVDLP
The following text describes a protein:
Function:
Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MTQPRICFLVGALILSCTCVSCSKDKCAVNEHNPNSNTSYDFVPHILHALAIHRPCVIGDPKCLCHVATIQRDLEPYVDKGITPEMMAQSKRLGTFYQIIRGRIYRQQKCLHPKRCADVEDLLLDMASGVADLEFVLNVRDWPQVHFLSGLSGPVFSYSITNRHLDIMYPAWSFWTTTGPILQHYPHGVGRWDWMRKHLVARASELPWSAKRAIGFFRGSRSSPERDSLVRLSQRRPDLVDAQYTILATDADPVEKMPLVEHCQFKYLFNFRGVAASFRLRHILLCRSLVLHVGDQWQEFFYSQLKPWVHYVPVASDADVDELAELILYLREHDDLAEEIAERGQQFIWLHLRMEDVQCYWSKMLQEYAKLLTYKVQREPGLLEVSNKKAVQLYRGK
The following text describes a protein:
Function:
Required for normal levels of gene conversion events during meiosis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAGVSPVVNHPYTTNSGDFIELGMEPAQKVQVDLDEAFNQMLHDGKVEEVVEAINGSPDLLSESDVENAKNNEHTYDIDNKNFNFEPKNSVNKTETIREELDQAASKILIETLDLHQKEGFEETIVTEEATDAVDLEAKGTTHGENDLDEVPTELNELANEVVDVDDVVSPSSELNAQSVNNILPISDDPKDSTSEAETRDFNWLSKGIVIFPNSSECAFYGNNNDEGMYLYSNGDDLNENTIEDFFGLVRARLESLNLLDSDSELLCEFPDLSLKINEDNVYASQIHLVDILEILTVHCDLEESFSIVFSTQPRFIARYNELVQAVSSSSNSEIDEVEDAETIDSKILEKRNDLNNEEPNSVVAEDGSEIITLDENDQSPNEATEKLRDNDLEESLIKDENLEDVEDENVKLDNYNIDGSLNNADLSQEPITNDGENVDWEATSEDVLERGYESAFPESEGTINSSKRRLSVTTDTENIELSDELASAGTPKKSKLMPSDD
The following text describes a protein:
Function:
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Sequence:
MNAIDPREIAINARLEGVKRIIPVVSGKGGVGKSLVSTTLALVLAEKGYRVGLLDLDFHGASDHVILGFEPKEFPEEDRGVVPPTVHGIKFMTIAYYTEDRPTPLRGKEISDALIELLTITRWDELDYLVIDMPPGLGDQLLDVLRFLKRGEFLVVATPSKLSLNVVRKLIELLKEEGHKVIGVVENMKLRSEQLDDEKDVEKLAEEFGVPYLVGIPFYPDLDAKVGNVEELMKTEFAGKVRELAGRL
The following text describes a protein:
Function:
Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.
Subcellular Localization:
Cell outer membrane. Note=Localization to the outer membrane requires InvH/SctG.
Sequence:
MKTHILLARVLACAALVLVTPGYSSEKIPVTGSGFVAKDDSLRTFFDAMALQLKEPVIVSKMAARKKITGNFEFHDPNALLEKLSLQLGLIWYFDGQAIYIYDASEMRNAVVSLRNVSLNEFNNFLKRSGLYNKNYPLRGDNRKGTFYVSGPPVYVDMVVNAATMMDKQNDGIELGRQKIGVMRLNNTFVGDRTYNLRDQKMVIPGIATAIERLLQGEEQPLGNIVSSEPPAMPAFSANGEKGKAANYAGGMSLQEALKQNAAAGNIKIVAYPDTNSLLVKGTAEQVHFIEMLVKALDVAKRHVELSLWIVDLNKSDLERLGTSWSGSITIGDKLGVSLNQSSISTLDGSRFIAAVNALEEKKQATVVSRPVLLTQENVPAIFDNNRTFYTKLIGERNVALEHVTYGTMIRVLPRFSADGQIEMSLDIEDGNDKTPQSDTTTSVDALPEVGRTLISTIARVPHGKSLLVGGYTRDANTDTVQSIPFLGKLPLIGSLFRYSSKNKSNVVRVFMIEPKEIVDPLTPDASESVNNILKQSGAWSGDDKLQKWVRVYLDRGQEAIK
The following text describes a protein:
Function:
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Sequence:
MAAEVPEPRVEFPLQGGYHNPTLRAWHATSAQLAKEHLMYPVFVSDHENSDHVEAIGSLPEQNRYGYNAVVKALEPLVQKGLASVLLFGVVDRKDVRGATADDSDNPVVKVLPLLKAAFPQLTVACDVCLCPYTDHGHCGIFMDTQPENESQQRFDPVASAKRIAEIAVAYAEAGCDIVAPSDMMDGRIQAIDAGLKAKGLRNRVAIMSYSAKFCSCFYGPFRSRKHSRAWSTHETYSDAAKSAPKTAPADQAEPATKVARRLVTPKGRHNYQLPPGSSGLAARANEISVREGADMLMVKPGIAYLDVLRDTKRLHPYHPLAVYQVSGEYAMLWHGAAQGAVDLREGVLESMTAFRRAGADIIITYYAPRLLQWLDE
The following text describes a protein:
Function:
Transport into the cell of 7-keto 8-aminopelargonic acid.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNRVGAVFLFVYERNFFLSIVPDRHRTEIRMSSSERSEVKFDKHFNWWSLLGIAFSLSCSWVGISASMAVGIASGGPLLIIYGLIIAAFFSLMCGISLGDFAAILPNSSGGSFWVLKMLEQESVTLKTPEYEDPSDDDEEVFLENYCQTFNVEVSSKFQKVSSMVVGLLNYFGAIFTTASICSSLSMSCIGIHKLLHPDYELKHWHVFVGYECINAVLTLFNIYSTPLPYISQFGLYTSLLSFAMTFIICIVSRSDNTVDPWPKASNIFGSFDNQTGWNSSGMAFVVGLVNPIWAFVGIDSATHMIDEVGYSKSRFLVPKVIITTIIVGFVTSFIYCVGLFFCITDQTAVVESILPIVEIFYQATGNRNLSVFLQCMCITTGFVSGIASGTWQSRILQSFGKSYAPFYKEGSLGNKSLKKLAVLTPGFKSPLYAHFLSQICVTIIGCIFMGSSTAFNAIITACITLLLMSYAVPSFIFLFVIKKEKFIHRIESDVNCVSRPNRRRMSMIPHIICILWTLFCLVFLSFPYTLPVTAGNMNYTSVVYAVVFCIISIVVFPTCI
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Subcellular Localization:
Nucleus.
Sequence:
MSHERADPTHLLEPPLKIYVSYLKERARLRVHLNDNSKMYMEGNLLGFDEYMNLVLGDSYEVYPKENTRVPLGTSLLRGECVGMVHPIPNIHI
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MKKFNQTFSSVKDLIGNKKETLTEFPDYIYKTKSLEDLKGYTRTLNLKLTKHSKTNQLLIEENKQLSEQILLYSNLFINNEESSLNVCEPLSNVFKIVGEMINEIENYRQTFEQSISQKWLQQLNEYGKSDCKDGQLAKNRFDKARLSFDEASEQFKQLRKKQNNINNEKLLEAEEDLDYATQQFSDIASESLQTMDDIIVKHNLDSFESASSTIQSYKDFFQKGLDHCLSVQSDLEIQKHAMSKYKQQLLEKKKLRSTVVQFEQTNSSRTISLPPPPPPKPTSSTPSSSPSPSPSSSIINIHNNYIAMPKGNTKVFGMALSTITEREKSDIPMIIDKSIQFLLLEENITQEGIFRVSPNQKQLTDLKNNVNAGYITTLDGIDDAHLISSFVKAFLREMPIPLFTFDLYHSLVDCVINEEKYDCDKIKISNAIVLVLQKLPKPNFLLAKSLISLLWKISTKSSQNKMTTSNLAVTVAPNVLYPKLLDIRSLTNANATIEFIISNFNNIFNNQLISNLYNNSCGVSGGSSGGGGGGGSSGGVANPRHSVLPPSLPARPQSVMFKNTPLSVNTSSSQSSSSSSSSSFASSASPPPTPTKPPSSSSSPIITTTSPNSNTNINSNTSVNTNINPRHSVLPPSLPPKKISSSSNSLPSPPPPSSPSIPEKSQNNITPTILSSSLSAPTSPTTTTTTNPLRSSTGSPKPISNRVSMYLQNSNTGVPLPSQKPQRVISNNNTTTNSRPLSNSLDLPPPLAPVGMPLETLEPIQRNLTSNEAITISEVNWN
The following text describes a protein:
Function:
Probable transcriptional activator involved in meiotic prophase and synaptonemal complex (SC) assembly.
Sequence:
MSDTTEVPRQSSENDQDNNLERTNSLKSPDVTNNIPSLFKLAAEWQINNPQETFQNHILENDVLKKINEITHLIRESYKDLSSQDGMMSKQQQEKMDWDLFCTVPVNIIEQYTKDMDEIYEKMERLAKQQRLWCESAFQIDVERCGDSILNAETWMKKKERHLEYKNIEMERSANEIKETIQRLTDDR
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MDPNMMAGLNGLAEEDQAKMASMIDQLQLRDSLRMYNSLVERCFVDCVDTFTRKTLQKQEESCVMRCAEKFLKHTMRVSMRFGELNQNAPTQD
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MTHIPCIRAGIEADDRCQMSDIIVQGQSVRVGIILTPQQVHFLSLLFTPSAADIMWTESIPAFAVIIGGMASSGLIIGGIQSLFHSGHTRKHGLDSFSRAMMQRDEAITGKQYAQNADLDFVPSA
The following text describes a protein:
Function:
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MGVLRLLVLCTLAACCVARSPPAPPLPNAPFAPLRPLGCNDSEVLAVAGFALQNINRVQKDGYMLTLNRVHDARVHRQEDMGSLFYLMLDVLETGCHVLSRKALKDCGPRIFYETVHGQCKAMFHVNKPRRVLYLPAYNCTLRPVSKRKIHSMCPDCPHPVDLSAPSVLEAATESLAKFNSENPSKQYALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQDSCSLQASDSEPVGLCQGSLIKSPGVPPQRFKKTVTVSCEFFESQDQVPGGENPADTQDAKKLPQKNTAPTSSPSITAPRGSIQHLPEQEEPEDSKGKSPEEPFPVQLDLTTNPQGDTLDVSFLYLEPEEKKLVVLPFPGKEQRSPECPGPEKQRTP
The following text describes a protein:
Function:
Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
Miscellaneous:
MISCELLANEOUS: The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.
Sequence:
MRKTFLTLLCVSSAIAHAADEDITFHGTLLSPPTCSISGGKTIEVEFRDLIIDDINGNYGRKEVPYELTCDSTTRHPDWEMTLTWTGTQTSFNDAAIETDVPGFGIELQHDGQRFKLNTPLAINATDFTQKPKLEAVPVKASDAVLSDTNFSAYATLRVDYQ
The following text describes a protein:
Function:
Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity. Required for cell homeostasis. May be involved in transcriptional regulation.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MEREASPWGLEPRDMQSPDEMGSPEGSLKGNMSENEEEEISQQEGTGDYEVEEIAFGLEPQSPGFGPQSPEFEPQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESDSQSPDFEPQSPRYEPQSPGYEPKSPGYEPRSPGYEPKSPGYEPRSPGYESQSPKYGTQSPEYEPQNPEFKTQSPEFEAESSKFQEGAEMLLNPEEKNPLSIPLGVHPLDAFTQGFGEQPAGGMPLGPPFEMPTGALLAPPQFEMLQNPLGLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR
The following text describes a protein:
Function:
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates. Type II pseudopilus confers increased bacterial adhesive capabilities.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MRLQRGFTLLELLIAIAIFALLALATYRMFDSVMQTDQATRVQEQRMRELVRAMGALERDLTQAVERPVRDELGDNRGAFLSEGENDQIVEFTRGGWRNPLGQARSRLQRVRWSLSGETLERRYWLVLDRAQDSKPRVQQVLDGVTALSWRFLDKEHNWQGHWPTDEGSEEERLESLPLAVEMTLEHRHYGKLVRVWRLLDPPLKQDQPQGQPGGENGENGEGGVPQPPEGMPGAPE
The following text describes a protein:
Function:
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxyde radicals into hydrogen peroxyde and oxygen.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein; Extracellular side.
Sequence:
MRLLSVLVFLISVISIAKADYQYAFCKFNELSIGGVEGIAHLLSTDGTTLNITFDFTTSYAQNTQFAAQILTYGYNPSSMTNLGSVFDPTNVKTAGCPSGTPRAGDIGNIQANGGNVEAQTISLNIPNIKDDANSIIGRSIAIYGGSYDCSDPSKSVIGDMISFCTIGVGNIDYSSFDKSKLTGVNTASSYSNLENAIGLAVVYNTTITKGDYIEGRVLFKALNSSFIQVSAKVSGLSYQAHGFHVHQFGDVSSDNGTSIGGHFLKTGQEHSLPPSGTRHYGDFGNFCAFSQDMMDTGYYYYETDHVTAALVIGRGMAVHNFTDKGNSDVGGSRCGQGVIALIQDADYSLNLPMDWKWDVICANGSYYGDMSTSMNSESYNDNEPGSSSTVIPFFALIIFSIIFALL
The following text describes a protein:
Function:
Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing. Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules. Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10. Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs. Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEIPTVNPVAIKPGTVAIPAIGAQYSMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVIPTVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAAAVYGGYAGYIPQAFPAAAIQVPIPDVYQTY
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
Sequence:
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFILSHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKPEISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEKNTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKIIGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKLIEDMLILNNPYTCPHGRPTMIKFTLKDLEKKFKRIQ
The following text describes a protein:
Function:
Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MDISAYQHMNIRMSTRGKRPLRNLTPNDKVRAIQRIHNGETKASVSRDLGVPESTLRGWCKNEQKLRFMCRQLGPDHLGIDTHTPPEKRAKFDLQLLPPKLATLPNYDDLGLSNFLFSATEFPTQKESLFEKLSLVEFVKKNGLHPSAIRELGDTHSLNAAANAVSGVDYSTNNMINQLTLLAQLNSKLSYQMGESADTDIKSPQSTTDITDTAREENSTKTSCPLLTVKNWAKDPAKRAHFNQATQLNPNNDKNNNAVDPSYSNLTTMKYPLIMEPVKSIYPETTVSAIPPPPFSTYSDLASAASAPTTDNDCQGAALLDWCKLFNASLNFLAFAAAAASMQPAGGTIPKSTATQLPATEADETYPFNNNLVKRLSPLAHSDASNESYFDSEPEDLSVRSCASVSSRNNSRSQTPDKSTATSIACLSDGEQ
The following text describes a protein:
Function:
This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.
Subcellular Localization:
Nucleus.
Sequence:
MKFTLGLGSRAWRVSWERAAAAAAGPGAGGALGSGSLRVSSRRGPRLARALPLCLSGGGGARALPDCAGPSPRRSGARQLAGPRAMEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEASKQPPPQPALPYNHIYQYPYPSPVSPTGTKMGTHPGVPGSAGHVSIPRSWPSAHSVSNILGIRTFMEQTGALAGSEGAAYSPKMEDWAGVNRAAFPTSPAVNGLEKPALEADIKYTQSASSLSAVGGFLPACAYPASNQHGVYSAPAAGYLSPGPPWPPAQAPPLTPHGAGVAVHGGELAAAMTFKHREGTDRKPPSPGGKATDALGSLHGLPIPASTS
The following text describes a protein:
Function:
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.
Subcellular Localization:
Secreted.
Sequence:
MTPPKLRASLSPSLLLLLSGCLLAAARREKGAASNVAEPVPGPTGGSSGRFLSPEQHACSWQLLLPAPEAAAGSELALRCQSPDGARHQCAYRGHPERCAAYAARRAHFWKQVLGGLRKKRRPCHDPAPLQARLCAGKKGHGAELRLVPRASPPARPTVAGFAGESKPRARNRGRTRERASGPAAGTPPPQSAPPKENPSERKTNEGKRKAALVPNEERPMGTGPDPDGLDGNAELTETYCAEKWHSLCNFFVNFWNG
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNKYKEQAQDILTAVGGVENIVDATYDTKCITIHMQHTIPSTANEVKQIVDVTSVAENDTQLVIKLNGNVDEVYQQLQRLIKNANVEESENTDNINSQDTSYTPQVKVTTPILVKAPIAGRRILLKEVRDSIFREKMVGEGLAIKAHEESKVIAPFNGLISMIVPTKHAVGIQSEDGVDIVIHIGVNTVDLEGKGFKCFVKQNDHVEAGQTLLQFDQQYIQQQGYNADVIVVISNSADLGKVELTMNEIITTEDVIFKIFKN
The following text describes a protein:
Function:
Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (By similarity). The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity (By similarity). Despite being highly expressed in brown adipose tissue, not required for thermogenesis (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MQALRVSRALIRSFNTTARNRFQNRVPEKQKLFQEDNDIPLYLKGGIVDNILYRVTMGLCLGGSAYSMYCLGWASFPRN