lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8G, together with C8A and C8B, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity.
Subcellular Localization:
Secreted. Target cell membrane.
Sequence:
MWTSGLCFLWHWTVDSDLEQCTPPPPCPITYCHRTAMLSPGAVLFFTLILMASSLGQRTRKPYGSTSPISTIQAQANFNAQQFAGTWLLVAVGSACRFLQEQGHRAEATTLHIAPQGAAMAASTFRKLDGICWQVRQLYGITGVPGRFLLQAPRARGPVHVVVAETDYQSFAILYLEQARRLSVKLYTRTLPVSDSALNAFEERVRGANLTEDQIFFFPKYDNTYKREHRPLLHSFITLFKLRDNSEFQVTNSMTRGKHCSTWSYTLIPTNKPGQFTRDNRDVSKMAPDSLQDWTDDWLAA
The following text describes a protein:
Function:
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (By similarity). Essential for embryogenesis (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAPRPRKRVSRPKPRATSRGRGGGDEDPFFESEPKRRRGGGRDEDIESEDSDLEGVAAAAAGGVGDDGEEEEEEEEEQETAGEKKMRIAKELLKKVTDAARRRREDDEDEDEGEEAGRRRVADILLKRQFEESGRKRMELADRILQPDPEDGFKMLVKHRQPVTAVVLSKDSDKGFSASKDGVIVHWDVETGKSEKYLWPSENVLVSHHAKPPLSAKRSKQVLALAVSADGRYLASGGLDRHIHLWDVRSREHIQAFSGHRGAISCLSFGPDSSELFSGSFDRKIMQWNAEDRTYMNCLFGHQNEVLTMDALSKDRLLTVARDRTMHLWKIPEESQLLFRAPATASLECCCFIDDKEFLTGSDDGSVELWSIMRKKPTHIIRNAHPVFRNNLNSLENNVEENGIHKPESVSSAQSWVSAIAARRGSDLAASGAANGSVRLWAIEPDSKGIRPLFSLRLDGFVNSLAIPKSGRFIVAGVGQEPRLGRWGRVRSAQNGVVIHPIRLKEESEDL
The following text describes a protein:
Function:
N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein.
Sequence:
MTSKSSSWKALLKNWEFKVAAFIGIYFLISHVVLETTDVVNEKGLKSHLKVLPEEVIDYYGKQPFSNVDKYAYMQYATNYDYLNLAIINFIHLRKANTKIPNLVIIYDEVLHYYASDKWSELYQVANQYKITLKAAPLIKASYQDDSNWAASFTKFHIFNQVEYDRIVFFDSDSMLVDIPNEIDFDNMESRFNHIDELFKIPQELSFASPQAYWLNNVVEGKSPRPRKNVEIPNKKRYSLRMKKLVNDLSIYQDFNLLPSLIYENHYFDNANHFFANHIMVITPSKNTFQELMRYIHNPWWWSITNRGSLRKPNDYDMEILNKYLNNELQRKRINVGILPHRVYGVLTGEFGEEWHERFVVEPQYLPFINKKSNKGWSPLEFFKKIKVVHFSDSPIPKPWEEENNEEHYNIKKIYCDKGDMEKFHKDYPVYKPRLTDDCDSVSIWNWFREQFYKERSGYWFA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MRPEQRRSDVMFRITKVEPSYGQNELEPTDYPTDWTAVEEKPDITRITIGEKEEAEHPTNDWETDEGFSDGWKPCKLQQGKMDKENLFLGFDMVKNAKHLRQLLVKPVNTAVPKKNKANKGFASQSNTSFPPSLPNGGHEGRLPEQSSSRLQPVLSRRHCLCNVCGKSFMWLSALNIHKRIHTGERPYKCSTCGRGFSQKTNLTRHQRNHTGEKPYGCTVCERRFTQKQHLSKHAKTHERLQNYQCTDCGKSFFNRQQLIKHQKIHRDPKIFLCKECGMCFPLKSNLKMHQKMHVKEAAFERKKSLKEKMLDKLQTRVKLERDSPGPPKRCETAFSWRSVGHPKIHPRERRFICNECGKSFSWWSALLMHMRMHTGEKPYKCSECGKGFRGCQSLTIHQRTHTGERPYKCMQCGKSFSQRPNLVRHQRKHTGEKPYVCPHCGKGFTQKQHMTKHLHVHSTDRQYKCKECGVVFKDLVTLSQHRKVHVKEQVCSCTVCGKNFIWLPKRTTSQKRPVKGKRKKCPQCEKVCKSQVNKKRSQGRAARNQALSIQREKVGPLQKQIKVKPFHCDQCGKSFGWWSAFNIHQRRHTGEKPYACTECGKNFTWWSALIIHQRTHTGERPFKCQSCGKSFSQKPNLVRHLRRHTGEKPYQCNECGKRFTQKQHLSKHQNTHGQGGDLRRGSRAGKKTTARRDLPRHLVESEALYNALPAVDFSQPLMSLPTESHALPKLFYHTKRPS
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MAAALRRLYGVSRLVMTNSQSWLLTMRAPPAASMVRPYTSGKDSSKPPSNPPMDRLDIVMSMEPAIPTYAPKQNEPFETRRARLLYQSRKRGMLENGLLFSTFADRYLNKFDEQQLKLYDRLINEPSNDWEIYYWVTGVKPTPEEYNNEVMDMLKQHAQNKNMEQRFRQPDLKEP
The following text describes a protein:
Function:
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway.
Subcellular Localization:
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Sequence:
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPLEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPVLESSLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERSRVRANSKSEGSPVLPHEPSKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGNNEQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGAEYGIGSSTKASFTPFVDPRVYQTSPTDEDEEDDESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
The following text describes a protein:
Function:
Endonuclease that specifically degrades single-stranded DNA and which is involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Required for double strand break-induced interchromosomal gene conversion.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
METKVHLPLAYQQQVFNELIEEDGLCVIAPGLSLLQIAANVLSYFAVPGSLLLLVGANVDDIELIQHEMESHLEKKLITVNTETMSVDKREKSYLEGGIFAITSRILVMDLLTKIIPTEKITGIVLLHADRVVSTGTVAFIMRLYRETNKTGFIKAFSDDPEQFLMGINALSHCLRCLFLRHVFIYPRFHVVVAESLEKSPANVVELNVNLSDSQKTIQSCLLTCIESTMRELRRLNSAYLDMEDWNIESALHRSFDVIVRRQLDSVWHRVSPKTKQLVGDLSTLKFLLSALVCYDCVSFLKLLDTLVLSVNVSSYPSNAQPSPWLMLDAANKMIRVARDRVYKESEGPNMDAIPILEEQPKWSVLQDVLNEVCHETMLADTDAETSNNSIMIMCADERTCLQLRDYLSTVTYDNKDSLKNMNSKLVDYFQWREQYRKMSKSIKKPEPSKEREASNTTSRKGVPPSKRRRVRGGNNATSRTTSDNTDANDSFSRDLRLEKILLSHLSKRYEPEVGNDAFEVIDDFNSIYIYSYNGERDELVLNNLRPRYVIMFDSDPNFIRRVEVYKATYPKRSLRVYFMYYGGSIEEQKYLFSVRREKDSFSRLIKERSNMAIVLTADSERFESQESKFLRNVNTRIAGGGQLSITNEKPRVIVDLREFRSSLPSILHGNNFSVIPCQLLVGDYILSPKICVERKSIRDLIQSLSNGRLYSQCEAMTEYYEIPVLLIEFEQHQSFTSPPFSDLSSEIGKNDVQSKLVLLTLSFPNLRIVWSSSAYVTSIIFQDLKAMEQEPDPASAASIGLEAGQDSTNTYNQAPLDLLMGLPYITMKNYRNVFYGGVKDIQEASETSERKWSELIGPEAGRRLYSFFRKQLKDYE
The following text describes a protein:
Function:
[Isoform 2]: Protein phosphatase specifically required for efficient dephosphorylation of the light-harvesting complex II outer antennae (LCHII) and transition from state 2 to state 1. State transition plays a central role in response to environmental changes and allows to adjust to changing light conditions via the redistribution of light excitation energy between photosystem II (PSII) and photosystem I (PSI) in a short time by relocating LHCII proteins (Probable). Mainly responsible for the dephosphorylation of Lhcb1 and Lhcb2 but not of the photosystem II core proteins.
Subcellular Localization:
[Isoform 1]: Membrane; Single-pass membrane protein; [Isoform 2]: Plastid, chloroplast stroma. Note=Associates with the stroma lamellae of the thylakoid membranes.
Sequence:
MALLRPHLHRFHSNTLRHSAYPSADAGGGLVVYPTYGRHRCSAIAIDAPSSLTGVTPIRWGYTSVQGFRDEMEDDIVIRSDAVDSFSYAAVFDGHAGSSSVKFLREELYKECVGALQAGSLLNGGDFAAIKEALIKAFESVDRNLLKWLEANGDEEDESGSTATVMIIRNDVSFIAHIGDSCAVLSRSGQIEELTDYHRPYGSSRAAIQEVKRVKEAGGWIVNGRICGDIAVSRAFGDIRFKTKKNDMLKKGVDEGRWSEKFVSRIEFKGDMVVATPDIFQVPLTSDVEFIILASDGLWDYMKSSDVVSYVRDQLRKHGNVQLACESLAQVALDRRSQDNISIIIADLGRTEWKNLPAQRQNVVVELVQAATTIGLVTVGIWMSSHLS
The following text describes a protein:
Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MGLSSRCGCRCECVTSTTHGDVVRNRSNRNNNDAPDAVLEGLAMAGLVAILRQLGDLAELAAEVFDDMQHQVMAASARGRRLAVRAKRLLETDLYLPPTTSTHNSAAAALSLTIATSSSGRLGCRAHPRRGGGGGGGGGTPPIMMPRLVVQRIRRCRGPPRLSLLDKFDAAGDGACLKRYTDPSFFFRTHSARLEQGTLGVRANRGPYLKSMSMETSRPKFQTAFNSEPPESADTVTDCKSESETERDASEAPSPGFLSMLRQLKQHRHRHRQAAGAGSLFRVQQTVDRVQSSPQLDMEKKLQGSGTAQPSPSPSELERTSSFEAWLSPDARRFPTTAAAAATHHHEHEEIITQEPPHPHGASATACSGSVSDVVTTSIGAALSSSTMLKAKQNSADAEIPCSKSSRRYKDSVEMIASRVSSLPRKLFINIKHHNDCSRSDRAGTTNLRISQATGTGDCSPELEAIPTPREAFLPTLVHSDPVYSSMHSLLLPENDKCYSYLQHHESIPCNVSVDAERHHQQEDPSTDRCSNSNSNSSTPETCTTPDSRNLLLPGSLVLKRASALPENPCSEDAKLDTTPPLPPIPPMQWLSERVHTGTRTRAPSPKHRALWKKSLEVTEMIQAIRQAHSHSIQTSPVDTEETLVSNEHTSANASHRDEMKCSESEETGHPQPFRAREDAVQASEGNVLKAGEFPVPAILSDEAGSEIYLRTQAQADTCFQQQGRQQFGSSGHSDHGSTEKRSEEHEDLQNESVFFSAVQELANMSPPPSVPRPKYPLLDAGSHGRIMLRNGPSPIHPSRNILDSRSLLIKQIKDIAMDGNPSFKLKSVSGASSPQSSVTGSPTNSKVATILQRLDDIRKAHANNNEVHSEESWSDGSE
The following text describes a protein:
Function:
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MGAARGGRRSLLWAAVTAVILVVDASYVHDLDDSFKENRKDDIWLVDFYAPWCGHCYTLEPVWNEVGKEMGGTGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKEDIVEFANRVAGPIIRPLPSQQMFDHVQKRNRVFFLYVGGESPLKEKYIEVASELIVYTYFFSATEEVLPEHITLPEMPAVLVFKDATYFVYDEYEDGDLSSWISRERFQGYLNVDGFTLYELGDTGKLVAIAIIDDKNTSTDHTRLKLIVQDVARNYRDHFNRNFQFGHMDGNEYINSLLMDDVKIPSIVVLNTSNQQYFLPHKPIESTEDMVQFINEILEGTAEAQGGDGILQRIRRIIYDAKSTVGSVFKSSPLLGCFLFGLPLGVISIMCYGICTADTDGGSDEAEMPKRETGRDLTDEGTEEEQEEESGESHVEYTDALEVKNVDLNCAENSISHSTHLFNVNKLIVRRGQPFGFYLHFQNREWDDENDKITFTVETGPKPCESLGTKSIFPLGGCPDHNHWNASFKLQNERCLCVDIFSPANACIGCYSLTMCLVSCGHKHSQNVGDFYMLFNPWCSDDAVYLDSQAHRGEYVLNEDGIIFKGLPKHITTHPWHFGQFQDDILDICLKILDTNTNFLRDPGMDCSCRNDPVYISRVLNTMVRLYCMKNNVGYVFFHLTFLKKCGVVHMF
The following text describes a protein:
Function:
Decyclization of 6-oxo-1,4,5,6-tetrahydronicotinate to form 2-(enamine)glutarate, followed by hydrolysis to form (S)-2-formylglutarate.
Sequence:
MSKTIIKNIGKIVSGDIKSPVLQADTIVVEDGLIAAIGGEELMKDAGDATIIDAAGSTVTPGLLDTHVHVSGGDYAPRQKTMDFISSALHGGVTTMISAGSPHFPGRPKDAAGTKALAITLSKSYYNARPAGVKVHGGAVILEKGLTEEDFIEMKKEGVWIVGEVGLGTIKNPEDAAPMVEWAHKHGFKVQMHTGGTSIPGSSTVTADDVIKTKPDVVSHINGGPTAISVQEVDRIMDETDFAMEIVQCGNPKIADYVARRAAEKGQLGRVIFGNDAPSGTGLIPLGILRNMCQIASMSDIDPEVAVCMATGNSTAVYGLNTGVIAPGKEADLIIMDTPLGSVAEDAMGAIAAGDIPGISVVLIDGEAVVTKSRNTPPAKRAAKIL
The following text describes a protein:
Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MRERCAAWDKDPVFGNLMKTNPEALKRVVPCGGDCQEPDLGLSNSDRQVLIDEVQIVIHTAATVRFVEPLHIALAVNTRATRLMIQLAKEMSHLESFVHVSTAYSNCVVEHVSERFYPEHLTCPAEKILELLESISPELLDKMAPALMGKYPNTYTYTKALTEQVIQKEAKDLPLSIFRPGVIIASYKEPMPGWIDNLYGPIAVLYGAAFGILHITLLNLKAQAGIVPVDYCVNMVLTCAWNTARDTSIKLSPEPPIYNFTPNNDNLITWGGFRDKAARLRYTYPLTKMMWLPFLHCTTIPWLFRFTAIFYHLLPGYAIDLALRLWGKKPRMIKLYDKIHKNIDILAPFVITSWSFDTVNTRKLWAKMSVEDQKLYDFNMSSVDWDDYFLQALAGVRIYLAKEEPGQEVVERGRKIYKRFEFLHRLLQFTLCGGAALILWSILKRLLGSFV
The following text describes a protein:
Function:
Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and inosine, as well as purine bases guanine, adenine and hypoxanthine, and purine base analogs 2,6-diaminopurine, 6-mercaptopurine and 2-fluoroadenine. Therefore plays a role in maintaining the cellular purine base pools and protecting cells against toxic purine base analogs. Modulates expression of the purR and G-box regulons.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLISVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAAMSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILFLGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTLYAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFAIIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQVGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL
The following text describes a protein:
Function:
Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal; KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules; KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MAVFKTTLWRLISGTLGIICLSLMATLGILLKNSFTKLSVEPAYTPGPNIELQKDSDCCSCHEKWVGYRCNCYFISSEEKTWNESRHFCASQKSSLLQLQNRDELDFMSSSQHFYWIGLSYSEEHTAWLWENGSALSQYLFPSFETFKPKNCIAYNSKGNALDESCETKNRYICKQQLI
The following text describes a protein:
Function:
Odorant receptor.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVNQSSAPGFLLLGFSEHPALERTLFVVVFTSYLLTLVGNTLIILLSVLDPRLHSPMYFFLSNLSFLDLCFTISCVPWMLVNLWEPKKTIILLRCSCILLTVMAFDRYMAIFKPLRHATIVHLCLCWQLASVAWVIGLVESVVQTPSTLRLPFCPHQQVDDFVCEVPALIRLSCEDTSYNEIQMAVASVFILAVPQPHPCLLWRLTAKGQRKAFGTCSSHLTVVTLFYSSVIAVYLQPKNPYAQERSKFFGLFYAVGTPSLNPLIYTLRNKEVTRAFRRLLAKEMGLIQS
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGHIWWGSPMSRQVGFYEYGVSPYHLKPLKGVINPGATLFLKRTGKQLLYIAPPVAFFYSIAVWADNKYEYNCRKAGIKAAAEASGH
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Sequence:
MVVTEYELKPQNFPRFPLDWSEIFGRKAKIVVEIGFGNGEFLAELARRHPEKDFVGFEVSITSFVKAQKKFKRYNLKNVRLVKVDARFGLRELFPDNSVEKVYINFPCPWPKKRHESRRITSYDFLQTLSAVLEMDGTVEFATDEEWYAREVLDTFESSEYFVVDVFEENFKRDVETRYERKWKSQGKKTFLIVARKVKNGTVKRLMEGENTMAHSVFEGNVTWEKLKELEGKVFKDKNKIFVVKKVYRDGDYLLKVISTDEGGFQQVYYLNLSGRDGKWVLKLDEGSDPYRTPALKWSLRRIPEELTAQGSP
The following text describes a protein:
Function:
Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. Encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. In this role, it may bind, possibly as a chaperone, to PhoR, PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB, or inhibit formation of the PhoR-PhoB transitory complex (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDSLNLNKHISGQFNAELESIRTQVMTMGGMVEQQLSDAITAMHNQDSDLAKRVIEGDKNVNMMEVAIDEACVRIIAKRQPTASDLRLVMVISKTIAELERIGDVADKICRTALEKFSQQHQPLLVSLESLGRHTIQMLHDVLDAFARMDIDEAVRIYREDKKVDQEYEGIVRQLMTYMMEDSRTIPSVLTALFCARSIERIGDRCQNICEFIFYYVKGQDFRHVGGDELDKLLAGKDSDK
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Sequence:
MVLFEAEEKAAAYKRASPTFRIRDNIHRRPHRLNPEEIRFDTHLRSSGKNFHFGVTDTGTAGHRQYDLKLKVIQDEGPWSPPLSPGSEDTEQSPTRIENGSYDAKRQHEIKTYLHYIKNGHENIKNLEAFHQYRDGDKLMMAQFFRICDGGNLKQLRMGYKEDKKIPPEQFIWRIYSQLIEALAFLHNEHPKYQNDPKHLNRPSILHPDLAAENVYLVWPFMQPRDGVYPDVRLGDFGKSLFVPIGKGVVIDDPDDNPKYKPPGINFISAKSDVWRAGSIMYSLTRLRGSTSTKIPWNTAENKSFADLTKEHQQAILMDPRRVHPIHLNYSEDLNVMIQKSLVLDHNKRPSAGELLKVLENPAKLRKNAEWMYRALPSWMVDKVISPDNTFSQERLNILTQPDQMALERKAHKKAKAAKRKMMREEEERKRAEDLKEQEHLEAADRYFAWEARESDLRRMTVVMDDDECDAFVDRFAVVRAAGLKAGTWVDPGPTYEEFLRLEKIYLAVQDAASQPK
The following text describes a protein:
Function:
Involved in the assembly of the cytochrome c oxidase complex.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAWWPFSRNNKPGVPEQDQVAAAPVQQRPAEPLPTNYTPGQRLLLEDTRPRFDTQSSASQQAVQRERATLADAWKTVRWEDFSLERMAGIPCFRDAGMAGFSAMVVAGSVTFLFHKNPVRAANWGVGGLLLGSIVGWEQCRMQRRRSFQVAEMARQTVAAKEAPMLRKPDNAQKAGAVSQASELPPKKPWYRFW
The following text describes a protein:
Function:
Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division.
Subcellular Localization:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Located to the spindle apparatus in a cell cycle- and microtubule-dependent manner. Located at the centrosomes throughout mitosis, at the kinetochore microtubules in metaphase cells, and at the spindle during meiosis. Has enriched expression in the posterior cortex of 1-cell embryos at anaphase, dependent on csnk-1 regulation of pkk-1.
Sequence:
MSVSTSVVKSMLQLTNYFGSNFTPKTETISSLAELWERHGSMIASMMSCDTREFGTADKFYEVIFRKIATTSLSFMTDSLEPKLAASGDSLEICKFYALFLEYMRKDHSGMLTRALEQASSENRVDTAVLLDMFLFFDNVYSESTADDWWACLRRDDEDQEASSGFRTPKRNNYSLTSLQTPTATARRLRTASSTARRSPIAEAVDSPTMKFMRSERELKQSKARIFGLEQMLGDLEDDKTKLSAENRTLKLSNSDLKSDIAKLKGIAEEAQFRAEELSCDLEAKKDEVHNILQQLNESRMTLRSEQRSLEEADIKKENLTAKLKTVTEDNGKLMKQARELRDLNDYEFARFRQQEQELTETLRATQDQMADLQEQLTGVEKIRASLKSENESLSASVEELSVASLRNKQDADNSKTMLSEELARFEETVDKLRQEKLEALSMANSRIDALRLEHSEREKMMKSTNARLQADLDEERNEKKRLMNLWNELNEKSLNVDKAVHKSNEEFQSMGSCLQNAKRQIEQLEVACKSKDDIIKFQEEQNKRAANLIKNEKAIRDQASAQFAEKLAILKNSLAEKENETVTLKENFASVVMKHKAELEEKELFLQSRVDLIQRLEHEVADLREKESAEIKKSTWMGERIKIFQQAPMRGSRIRCGSPDSLPDFLADNGPTITEEELRAQLATFPRKSIAPSVDDNEFDKGTPIGFKSNMYDGRESICSLDFFDRSSLQRSSMRSESIQLASPSSAGEFKQPFTPSGVTKERVGVLTARNEKVKPHLKCSYASEVGSTNSPSADEENIKKSKKKNRRDSIFSAFSSKKQ
The following text describes a protein:
Function:
Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif.
Sequence:
MDAAGLDSEGRGFASAREMWREEIGIGEEGEEAENGAPCKRRDWYQKGIAYWEGVEASVDGVLGGYGHVDDADVKGSEAFLKPLLLDRFGSGARHPVALDCGSGIGRVTKNLLLRYFNEVDLVEPVSHFLEAAREKLATDKDNSDHKAINFYCVPLQEFTPEVGRYDVIWIQWCIGQLTDDDFLLFFKRAKVGLKPNGFFVVKENTARSGFVLDKEDNSITRSDSYFKELFKQCGLHLYRTKDQKGFPEELFPVKMYALVTDRRQGSNNGRGKTRQHKPAVIKS
The following text describes a protein:
Function:
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission (By similarity). May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L (By similarity). May be involved in peroxisome organization.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MAALSKSIPHNCYEIGHTWNPSCRVSFLQITWGALEESLRIYAPLYLIAAVLRKRKLEYYLYKLLPEILQSASFLTANGALYITFFCVLRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPETAYAKVEQKREKHRGTTRAMSLIALVRSLVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTEPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIVAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPQADTIIYSISTAICFHAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKALDVFGTGASREFHNFIPRLDPRYTVVTPELPIDFS