lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular Localization:
Nucleus.
Sequence:
MFEVPLVQGSILKKVLEALKDLINEACWAISLSSVNLQSMDSSHVSLVQFTLPSEGFDTYCCDCNLAMGVNLTIMSKILKCAGNEDIVTLRIEDNVNTLVLVFEASNQEKVSDYEIKLMDLDVEQLGIAEQEYHYVVKMLSGEFASILETLEMENKLSQTSTVNKEEEAVTVEMNEPVQLTFALRYLNFLTKATPLSSMVTLNMSADIHLVVDYKIADMGHLKYYLAPKIEDEEGP
The following text describes a protein:
Function:
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSVLNQSGEEQVECPLCMEPLEVDDLNFFPCTCGYQICRFCWHRIRTDENGLCPACRKAYSEDPADFIPLSQEQVAKLKAEKRQRDQQRKAKLSESRKHLASVRVVQKNLVFVVGLPMRLAEPEVLKRHEYFGKFGKIHKVVINQSTAYAGSQGPSASAYVTYMKSDDALRAIESVNNITIDGRLVKSSLGTTKYCSHFMKNQPCPKPDCMYLHDFGDPEASFTKEQMHAGKHQEYEKKLHEALLQRTNNNNTNVTTTETKPTTKSKEPVAAATPTNGTNKDNWPQLNSEKENSKEKKAEKSTESKDKVTKGKSKEKSKEKKEKKPEVKVAKDKEETKKESGEKLSILDDNTSFFSHNSFQKIVPENREDDDSPNQTSPSLLTDSLPDINTSEDWAAAFGFNKTSETTVRSESSQSPIDSFFRTDDFRNIIEASLTTAKNNGYTKPPQPATTTTTTSENYFGKESGLDQHMSKFFMDFHTKNGQKESNGFTMNHNMNGFQVNNYFINQDRLFLLQQKKIEEHLVNLSLKQQNQSYGGFMNGDVVAQNGYGGGFQGQMYQNPQPVQKSRTHAEDDLGFDPFQETQKALAELIANEQSYKAHSNVRGGMSSSQMNGVVHSQSGKSHLPPPPPGFVQPTTHMNSFGSKILPFLNMSNQQISSSTQQQQQNWPSYNSQVQPPPPPQQQQKNANSCNDWKDFDSAIVTTSRHYPIMGPINNPFRSLQQQLGTQQIPNGSLRSHEFTNNAFSNFTQQLQQQQPSYSNYSSHLNNTTQQQQQNLSWFTSELNTQISSPPGFRTATQTSKQQEC
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MAGIDLNTVEEEDEEAETPLGLREGGTVCLDLWHACAGPVAPLPRKGSAVVYLPQGHLEHIGGDAAPAAVPPHVFCRVVDVNLHADDATDEVCARVSLLPEDEEAERRARARAREDEDAARYGEGGGAMRPLARTPHMFCKTLTASDTSTHGGFSVPRRAAEDCFPPLDYSLQRPSQELVAKDLHGTEWKFRHIYRGQPRRHLLTTGWSAFVNKKKLVSGDAVLFLRGEDGVLRLGVRRAAQLKNVNLIPAPHNQCSNHRNLGNVTEAVATRTVFHIYYNPRLSQSEFIIPYWKFMRSFNQPFSVGMRCRMRYESDDASERRCTGIIIGSREAEPMWHGSKWKSLVDLKLICAPPNSKRLKPCLPQVNPEIVLPYGSVSSDFAGSARFHKVLQGQEFLGFKTHDVTAISASHATEARNLQDSDERSSYINMSNNIFGVPRFGVRSPAGIPRFPYHCSGFGESQRFQKVLQGQEVFRPFRGGALADVHIRTVGMYQPDGTHASSAAYKWPTPQGCDIRHPTKPVLLQASSPSSVLMFPQTSSKIPHLEYEYSCLDEDEDGRRDRAVPTQDMGRSNQALSLWPHLVSGEAIDECTVTEKMHSPVSGAEHESNNESTVENGCKIFGISLAEQVRSCDEADSCNANCNSRLQPSQSQMQSLGTCWATVSAS
The following text describes a protein:
Function:
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MYPLDGSARPHPPGTTRLNSVEPDKQIGFTVLVRPQTGAPRLPDLAQWQAIPIAERQFLSTAGFERTYGSSEDDIVSVASFLEKAGMTIRSRHAGAGTVEVQAKTCQIHSVFAVQLLYYRGQLRPAARKRRDDKQPAEETYIGFEGCISLPAALHDKVIHIFGLDTRTFGASGGYSGDPPRAQRLIVAELAALYGFPAGVDASQQTIGIFSGEGNDDKGQSLSNYRPADVAAYFNNQTVGYNRAPTVVPVSLTVADQTYRNDPDHPTQELSQDIMTAATIAQGCTVNVYFSDLTEQGWLAFLTRVLFPQGEEKRPTIVSISWTMYDEQTYRDRLSFLFQRLAVVGTSVFAIAGDWGANNNIIDGQPHVGWPGSDPWVTCVGGTVVGNVRSSGAFTEHAWSDRDNPDSQFTIDGHLGVTGGGMSRVFATPPYQLSSGISAVTDCNGERWTGGRFIPDITGMVGFRGFIVNGKRNYFIGTSCSTPLYAGLFAALASALGGGGEGGVLFGPLNTVLYQIDRGVYRDITFGHNDSGDMPACAYFAAGEGYDTVSGLGSVDGRRTLEELRRIYWPKTKGFGCFRN
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of toxin ParE.
Sequence:
MPLPGGTLWQSLPSGRCMATMNISLPDELKEFVDQQVLEHAYGSSSEYLRELIRMQRDAQSLRALLLDGAESGPAVAMEADFFDSMRARARQRAAGK
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MVLIAAAVCTKNGKVILSRQFVEMTKARIEGLLAAFPKLMTAGKQHTYVETDSVRYVYQPMEKLYMLLITTKASNILEDLETLRLFSKVIPEYSHSLDEKEIVENAFNLIFAFDEIVALGYRESVNLAQIKTFVEMDSHEEKVYQAVRQTQERDARQKMREKAKELQRQRMEASKRGGPSLGGIGSRSGGFSADGIGSSGVSSSSGASSANTGITSIDVDTKSKAAASKPASRNALKLGGKSKDVDSFVDQLKNEGEKIANLAPAAPAGGSSAAASASAAAKAAIASDIHKESVHLKIEDKLVVRLGRDGGVQQFENSGLLTLRITDEAYGRILLKLSPNHTQGLQLQTHPNVDKELFKSRTTIGLKNLGKPFPLNTDVGVLKWRFVSQDESAVPLTINCWPSDNGEGGCDVNIEYELEAQQLELQDVAIVIPLPMNVQPSVAEYDGTYNYDSRKHVLQWHIPIIDAANKSGSMEFSCSASIPGDFFPLQVSFVSKTPYAGVVAQDVVQVDSEAAVKYSSESILFVEKYEIV
The following text describes a protein:
Function:
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation. May also be involved in the early steps of isoprenoid biosynthesis, possibly through its role as RssB regulator.
Subcellular Localization:
Cytoplasm.
Sequence:
MKWIVIDTVIQPTCGISFSAIWGNMKMIIWYQSTIFLPPGSIFTPVKSGIILKDKEYPITIYHIAPFNKDLWSLLKSSQECPPGESKITNKCLHNSCIIKICPYGLK
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Subcellular Localization:
Secreted.
Sequence:
MAAARRLPVLELVSFVAVLLISSPTAAAAELSVDFHAASCPPLEAIVRSSVQAALQQEIALAAGLLRIFFHDCLPQGCDASVYLRGGSNSEQGMGPNLTLQPRALQLVDDIRAKVHAACGPTVSCADISALATRDAVVVSGGPSYAVSLGQKDSLAPAPVRLVNQLPGPGTSSVQALLDKFGSKGLREAADLVALSGAHTVGRAHCDFFRDRAARQDDTFSKKLAVNCTKDPNRLQNLDVVTPDAFDNAYYVALTRKQGVFTSDMALIKDRITAPIVRQFAADKAAFFRQFAKSMVKLSQVPRTDRNVGEIRRSCFRTNGPRLVDLATGDEAASP
The following text describes a protein:
Function:
Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters.
Miscellaneous:
MISCELLANEOUS: Present with 1900 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere.
Sequence:
MFNRTTQLKSKHPCSVCTRRKVKCDRMIPCGNCRKRGQDSECMKSTKLITASSSKEYLPDLLLFWQNYEYWITNIGLYKTKQRDLTRTPANLDTDTEECMFWMNYLQKDQSFQLMNFAMENLGALYFGSIGDISELYLRVEQYWDRRADKNHSVDGKYWDALIWSVFTMCIYYMPVEKLAEIFSVYPLHEYLGSNKRLNWEDGMQLVMCQNFARCSLFQLKQCDFMAHPDIRLVQAYLILATTTFPYDEPLLANSLLTQCIHTFKNFHVDDFRPLLNDDPVESIAKVTLGRIFYRLCGCDYLQSGPRKPIALHTEVSSLLQHAAYLQDLPNVDVYREENSTEVLYWKIISLDRDLDQYLNKSSKPPLKTLDAIRRELDIFQYKVDSLEEDFRSNNSRFQKFIALFQISTVSWKLFKMYLIYYDTADSLLKVIHYSKVIISLIVNNFHAKSEFFNRHPMVMQTITRVVSFISFYQIFVESAAVKQLLVDLTELTANLPTIFGSKLDKLVYLTERLSKLKLLWDKVQLLDSGDSFYHPVFKILQNDIKIIELKNDEMFSLIKGLGSLVPLNKLRQESLLEEEDENNTEPSDFRTIVEEFQSEYNISDILS
The following text describes a protein:
Function:
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNTDEGIDPARIKLLTLLNVAAAKPTTTTTTTTTTTNNRKRKLGQDRNWLAIAKQATIKPKTPSTTTTTTTTTTITENQVAEEQEEDESNSVDLYHHHFGPQTTLLNPQALQLAQKEDGWKVASNSKTQDHRRIVSFQLDQQQEPDPPSSSNNPTLKIPKALQPVLDRFNPHELRFFDSVNQYQDVWHTGIPYDHHRAHLRTATSLWALQHILKTRAEIIKNNEHLAQLAPKPSTKKSILESDLEGEGLGDEPSEKSKTQKAEREIRDQGFTRPKVLMLLPFRSSARDWLHSLISLASTSTVKGLERFEKEYSLPPGTVDKLEAEDAKFKYPLDHRIIFRGNVDDDFFLPVKFNRKEIRLYSDFYQADLVIGSPVGLRKFIEKEGDADFLSSIEISIVDQLDVMQMQNWEHVEFVFEHLNRIPKKPRDTDFSRVKPWYLDSQAHHLRQSVMFSAHPSAEQHSLFRKLDNLSGKRLEFHETSKTYSVGLVAKVRPGIQQTWRAFDLGPDPLMDHQLRFDFFQKNILGPLQQSALVKEGLAGILVFVPSYFDFVRLENLFRSIEDLKFAAISEYSTPSEISAARSSFFNRHVSYLLVSERFHFFHRYKLRGARQIIFYAPPYHPEYYLEFVNEFPFLPSQNQPKDGAPGDGTFGPVDVKEVSVQVLFSKLDHAKIQPIIGLADSHKILKNLDHAHSFTFV
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.
Subcellular Localization:
Nucleus.
Sequence:
MEVDDFEARTATFSSWLKEMGVRTNPKMALVDLRQEGRGRGVVATGDIDDDEIIFSIPRNAVLNAQNVAPLPVSRRLFEKMPSWLVLTSILMTEAQMENSKWAPYLAVLPERLDSLVFWSDSELAELQASAVVKKIGKKDAEDMFKSYIAPQGLKHSSTEMCHKVASVIMAYAFDIPDPSDAPTSGGKGGEAGDDLVSDDGEDEKTILSMIPLADMLNADADRNNARLICDNEELEMRAIKPISKGEEIFNDYGQLPRSDLLRRYGYVTDGYSAYDVAEISAELIVSLFRNGKVHPSLHKLTQDGLKTRLELAEREGVYEDSFDLVHSSPDEPSIPDELLAFLYLLLVDESHLKAILNSESSIPSRSKLTTELAGQVLATLLQAREKEYSTTLEEDEDLLKNADLPVRHAMAIQVRSGEKKVLRAAMQEATAFSCGNHRMRLVSSQEGMKKNAKRKGEETEQPKKKGRAR
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MRILGTKLALFSILLIAPIFIFVKGGYGSLEGGCSGASDSGSCGSAPQDGGGPSADAGSCGGDAPPSGGPSEGMCGAPPKDEGGSCGGGSSSPGQGMCGAGGGGDGSSASNMPQVSRSMESKIKLRRILRKIDTNKDRKITEQELKDHIKTMIDARLAEEGKKLMELYDNNMDGGVTWDEYANRSGYNSGDLSEPTGDQEKAKLNEKRRFAAADTDKDEKLTAVEIAMMMMPEDSPNMADVVIAEYLDNFDKDNDGKISKKEFIGAGSEDEKLDKEVEEGLATQFDDDDRDSSGFLEKDEIAGMLMPDDASLLFRNTDTDMDGFLTEKEIYKNYMQFASSRITDFGELIKEDKKVTQEDQEPEKKSNESDPQKDQETDNKTSKKESQEELREADETPKKKDEL
The following text describes a protein:
Function:
Required for mesendoderm differentiation. Interacts with glucose transporters and promotes glucose uptake. Probably augments the glucose uptake capacity of glucose transporter proteins to meet the energy needs of mesendoderm differentiation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
AITAGALQPGRLSVHREPWGFSREQAV
The following text describes a protein:
Function:
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.
Subcellular Localization:
Cytoplasm.
Sequence:
MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAWVTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGSQ
The following text describes a protein:
Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines; Isoform 3 does not mediate any NK cell activation.
Miscellaneous:
MISCELLANEOUS: Proposed to be involved in systemic lupus erythematosus (SLE) disease process.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Sequence:
MAGSPTCLTLIYILWQLTGSAASGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGAADDPDSSMVLLCLLLVPLLLSLFVLGLFLWFLKRERQEEYIEEKKRVDICRETPNICPHSGENTEYDTIPHTNRTILKEDPANTVYSTVEIPKKMENPHSLLTMPDTPRLFAYENVI
The following text describes a protein:
Function:
Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MAQEKMELDLELPPGSAAAPSDGGGLRRSNSAPLIHGLSDNSQVFQGSVLRTRRNSTTVMNRHSLFVPSSPIRIPSSRLHQIKQEEGMNLMNRETVHEREVQVAMQMSQSWEESLSLSNNDFEKSSSPKQVDFVPVSPAPSPTRGIGKQCFSPSLQSLVSSSGLPPSPSPSPTRRFSSRRSQSPINCIRPSVLGPIKRKGVTEMEDHPKRLFQGSTNMLSSEALHQPDLGGCLSAHTLDDNRSSAGSSCDSPAEAGASTGSPVSLSDSRSPFLPVDLTAKLPID
The following text describes a protein:
Function:
Has very strong antibacterial activity against many Gram-negative bacteria and the Gram-positive bacteria S.pneumoniae and Enterococcus sp. There is moderate antimicrobial activity against the Gram-negative bacterium P.aeruginosa and yeast C.albicans and weaker activity against the Streptococcal strains and E.coli. Has hemolytic activity against human red blood cells. Seems to disrupt the membranes by adopting an alpha-helical conformation.
Subcellular Localization:
Secreted.
Sequence:
GLLGPLLKIAAKVGSNLL
The following text describes a protein:
Function:
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Subcellular Localization:
Cell junction. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein.
Sequence:
MAVWTRASKSGLLDLLLQDHWLSVQAELTGETLTLTSEPEPSGALNGLSNGTELAPASPRRAPSSHNSPRAGSECGSESALSSPGTRFHLDVPAIDMGCEPVRKVRVVKQESGGLGISIKGGQENRMPILISKIFPGLAADQSRALRVGDAILSVNGTDLRNATHDQAVQVLKKAGKEVTLEVRFLQDVSPYIRKASLVGDLLWDTYDLHSPVHSDISGSPNHHSKDYKVIPLKMCYSARNLSMSDPEGRLVELRSPDGCHSLVLRCRDSASALSWSLALHNNITSLLPQVLAETQSMLGPTGEDIRHLGWVAEQVSQDDGRSLWQPVLAAVSQKDFLLFDAMPRAREEWARPKHRLPLISTRLVHSGPGHSSPSLGLHLTFGSRTGCPQGIDRRVFRVESQRELSTWTRALVQGCNSSAELMREVTVSCTLREQEVSLIIHYDTGFTVCQGGPSGPVLHRYPYEKLRMSADDGNRHLYLDFGGPEGELALDLHTCPKPVVFLLHTFLSAKVSRMGLLA
The following text describes a protein:
Function:
Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSAPVFTCISCRVAFASMDLQRAHYKSDWHRYNLKRKVAELPPVTAVEFKQRLLAQQSKTAEEARDTSTRCGVCGKHFGTENAYTNHLGSKKHKEAEAKIKAASSADNGDEVSVKNEKNKRDQAKVDAYEGQKMMREGAEKKKELKIEDNAASSSSPSSSSSSSRKGNKPAVPAQADDDEVMDDEEREAEWEDVEGEEIPPSDCLFCSRSSSSIEKNLHHMTVSHSFFLPNVEFIVDMEELLTYLGVKVGCDFMCLWCNNKGKAFYSLDSVQRHMRDKGHSKMLYEGDAIYEYSDFYDFRKSYPDFDAKNGGAVGGEVKDGEEEDEEEEMDLGSCEMKEEGFELTLPSGIKIGHRELSKYYKQNLPLERRVAKKNPALIGRLMTQYKALGWHGLKGEASEKMIRDLRYVQKFRSKKHLSLGVRANKFQTYFRCQNPI
The following text describes a protein:
Function:
Probable cellulase. Can hydrolyze barley beta-glucan in vitro. Could be important for the survival of M.tuberculosis in the environment, perhaps in amoebal hosts.
Sequence:
MGTNLPTEVGQILSAPTSIDYNYPTTGVWDASYDICLDSTPKTTGVNQQEIMIWFNHQGSIQPVGSPVGNTTIEGKNFVVWDGSNGMNNAMAYVATEPIEVWSFDVMSFVDHTATMEPITDSWYLTSIRAGLEPWSDGVGLGVDSFSAKVN
The following text describes a protein:
Function:
Negatively regulates salt stress responses and Na(+) homeostasis. Prevents Na(+) efflux, disturbs reactive oxygen species (ROS) homeostasis, and represses the expression of nuclear salt stress-responsive genes. Involved in resistance to abiotic stress.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion.
Sequence:
MAQYHQQHEMKQTMAETQYVTAPPPMGYPVMMKDSPQTVQPPHEGQSKGSGGFLRGCLAAMCCCCVLDCVF
The following text describes a protein:
Function:
Catalyzes the release of inorganic phosphate from 2',3'-cyclic nucleotides through consecutive 2',3'-phosphodiesterase and 3'- (or 2') nucleotidase activities. Also possesses a 5'-nucleotidase activity. Does not catalyze the release of inorganic phosphate from 3',5'-cyclic nucleotides. Probably plays a role in the cellular reprocessing of nucleotides present in the medium, under conditions of phosphate shortage.
Subcellular Localization:
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase SrtD.
Domain:
The N-terminal region (amino acids 35-623) is able to catalyze the release of phosphate from 2',3'-cyclic nucleotides, but not from 5'-nucleotides.
Sequence:
MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVHLSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGNPLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADFPIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEGQVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGIDAIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSWKVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKDDPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIKNVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDVIDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGGGGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLLAKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLDDAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGNHEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQTFTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVKAIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIVAQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELEDVKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAGIDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYTFTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGEDLGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANTPFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADTAIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDRKKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGGSDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILLAGFLISALGTAMYLHQRRKQNRANQA
The following text describes a protein:
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MALTWTHVLRSWIFFSVFLCCWIFTNGQIVYSISEEANPGTAVGNLAKDFNLNVQDIERRGFQIVSESNKRYFDFNFKTGVLHVKERIDREELCEQKIRCSLPLEAIVNSPLNVYRFEINVLDINDNPPKFRTPKTTINISESALPGEQFALPSAFDADVGINSVKSYKLSPNEHFSLDVQSGGEQSVSAELVLQKALDREKQPLIRLTLTAVDGGKPLRSGTMQITVNVEDVNDNIPVFSKSLYKARVNENAPPGTPIITVQASDPDEGVNGQIVYALVNHDNDRNVESFAINPETGEITVKGDVDYERKNAVELRVQAKDKGHKPRAALCKVLLEIIDVNDNVPEISVTSLVNTVKEDALIDTVVGMITVTDNDAGKNGQVILNIQGSSPFKVQNSYKNYYTLFVNGPLDRERASEYNVTISAADEGSPPLSSTSVIAVHVSDVNDNAPRFPEPVINVYVKENSQIGAVLHTVSAVDPDVGDNARITYSLLESSKSGPVTSMININSDTGDLHSLQSFNYEEIKTFEFKVQATDSGVPPLSSNVTVNVFVLDENDNSPAILAPYSELGSVNTENIPYSAEAGYFVAKIRAVDADSGYNALLSYHISEPKGNNLFRIGTSSGEIRTKRRMSDNDLKTHPLVILVCDNGEPSLSATVSIDAVVVESGGDVKTPFRHAPVKEESFSDLNLYLLIPIVSVSVIFLLSLIGLIAVKCHRTDSSLGRYSAPMITTHPDGSWSYSKSTQQYDVCFSSDTLKSDVVVFPAPFPPADAELISINGGDTFTKTQTLPNKEKPKVPSSDWRYSASLRAGMQSSVRMEESSVMQGAQGVLVQNWPTVSSAPDNEGGEVSPPVGAGVDSNSWHFRYGPGPGGPPHLKPGEVPPEAFIIPGSPAIISIRQGQDGDDKSDFITFGKKEEAKKLKKKKKKEKKDKREKGKDDDD
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSDKSELKAELERKKQRLAQIREEKKRKEEEKKKKETDQKKDAVPAQEESDLDKKRREAEALLQSMGITAEPPMAVQPLRIVTEDTCLFHYLVPPPTSPSSKSVSTPSEAGSQDSGDGTGGASARTAVTSKTLHWDTDPSVLQLHSDSDMGRGPMKLAMSKVSQVDFPPRETVSYTKETQTPFLTKDNEGDEDEEETVAPKAVAVQEEDKPEKKEENTEAPPHELTEEEKQQILHSEEFVSFFDHSTRILERALSEQVNIFFDYSGRDLEEKEGEIQAGAKLSFNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVTSAAFARFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSQPQDSMELVHKQSKAVAVTCMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHSAVGAIDFSHLFVTSSFDWTVKLWTTKNSKPLYSFEDNSDYVYDVMWSPTHPALFACVDGVGRLDLWNLNNDTEVPTASITVDGNPALNRVRWTHSGREIAVGNSEGEIFIYDVGEQIAVPRNDEWTRFARTLAEINANRADAEEEAANRIPG