lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MISAWLWLLCFSVIQTFTAEAQPTESLHTEVPENYGGNFPFYILKLPLPLGKDEGQIVLSGDSGTAAENTFAVDPDSGFLVATRALDREEKAEYQLQVTLESEDGQVLWGPQLVTVHVKDENDQVPQFSQAIYRAQLSQGTRPGVPFLFLEVSDGDAPGTTNSDLRFHILSQFPVQPLPDMFQLDPQLGALALSPDGSTTLDHALEEHYQLLVQVKDMGDQPSGHQAMATLEISIVENSWTPLEPVHLAENLRVAYPHSIAQVHWGGGDVHYQLESQPPGPFEVDAEGRIHVTMELDREAQAEYQLQVRAQNSRGEDYAEPLELQVVVMDENDNAPVCSPHDPTISIPELSPPGTEVARLSAEDLDAPGSPNSHIVYQLLSPEPEQGAENKAFEIDSTSGSVTLGTAPLHAGQNILLQVLAVDLAGSEGGLSSTCEVAVMITDINNHAPEFINSQIGPISLPEDVKPGSLVATLMATDADLEPAFRLMDFAIEEGDPTGIFDLSRESDSNHVQLRLRKNLSYEEAPDHKVVVVVRNVEELVGPGPGPAATATVTILVERVIPPLKLDQESYETSIPVSTPAGSLLLTIQPSDPMNRTLRFSLVNDSEGWLCIKEVSGEVYTAQSLQGAQPGDTYTVLVEAQDTDEPEMSTSTTIVVHFLKASPVPALILASGPSRHLCTPRQDYGVVVNGVSEDPGLANRNGPYSFALGPNPTVQRDWRLQPLNDSHAYLTLALHWVEPGEYTVPVVVHHDAQMWQLQVQVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGVLLGTLAAIGFILILVFTHLALARKDLDQPADSVPLKTAV
The following text describes a protein:
Function:
Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.
Miscellaneous:
MISCELLANEOUS: Present with 1380 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Note=Recruited to chromatin in response to replication fork stalling.
Sequence:
MSTSLLFEQLNFLILVAAEAELPIAHSTRKLLMDNSCNNCQIYELYNENLKDVKTDKDWFMNKFGPQTVHFVISNTINFPFYKIVYFDLLIPVVSHTWVQDSVKTKRHLRTNMYSPNPFHLLRDCQVYISKSSFNKCEYILYSDLLHLLGGTLVNYISNRTTHVIVQSPQDPIIATVSKLTFGSFSSSSTNKHTEKPLREWKFVYPIWILYHFKMAKPLKGELATLCELDMQDTSEEQLFAKWEEVIGDKQTSSSQLTLHPNKTLFKNHHFAISPDLNFFTPLYWFLKGFIEDLDGKVTPLSFSDDLKSVYQAFPDIDCYIGHSANSPILEKTKSIKPEIHVGNVSWLFYMFALQKFTPVSQCKLIHQPFHAKLFTSKELTVAYTNYFGSQRFYIQRLVEILGGLSTPELTRKNTHLITKSTIGKKFKVAKKWSLDPQNAIIVTNHMWLEQCYMNNSKLNPKDSRFQNFKLDDNMGWNIGQIGMDHSSLPTPKNLSMVTYDTQSISEKPPPTNDQMDQINDNTNVLSKKDGTPISSFENSIDEKIDKLQKISGEVAVTHSGDLERSFVSRPSRASFPVVDSKKSNLQKKDSNSDISMETEVFCEGHEKREEKEFTKPITEYDAPKKQEIREQSRKKNDIDYKKEEEETELQVQLGQRTKREIKTSKKNEKEKETNECHIEVDQMTNEKQGEESTGKLISTEDVTSKKDTDKFSHLFEGLSDNDDHINDEKPAVNSKYTTPKTSQNITSGVDTPTTAQTQVFMPSSGNSRLAKTQAAKRLHTDIESLNEFQKNFKRKRIDSEEISLSQDVERSNNNKELATKAEKILARFNELPNYDLKAVCTGCFHDGFNEVDIEILNQLGIKIFDNIKETDKLNCIFAPKILRTEKFLKSLSFEPLKFALKPEFIIDLLKQIHSKKDKLSQININLFDYEINGINESIISKTKLPTKVFERANIRCINLVNDIPGGVDTIGSVLKAHGIEKINVLRSKKCTFEDIIPNDVSKQENGGIFKYVLIVTKASQVKKFTKLINDRDKNETILIVEWNWCVESIFHLNVDFTSKKNVLYQKKNN
The following text describes a protein:
Function:
Transcription factor required for protein utilization and degradation. Regulates transcription of major secreted proteases.
Subcellular Localization:
Nucleus.
Sequence:
MTRTVDEIKYETPSSWEHKSLDVAEDGRRLAPHSDTARPKGRIRRSMTACHTCRKLKTRCDLDPRGHACRRCLSLRIDCKLPETTDRFQDSAAMWPDATSAIPSIEERLTSLERCMREMTGMMRQMLDHSPGFANASVPHLTKSIITDENASMEGSPSSPFLPKPVRLIQDLQSDFFGEAETSPVDSPLSSDGNAKGAIDSKLSLKLLQTFVDHFGACVSIYNLSDIHNDMKAPDSLLYNTACLLASRYVPGIPTSTVHAIYLQVRHAVVNILWEKPPLKYETLQALALLCLWPATAQKEPPMDSWLLSGISINHAIIALDFLNYAPSEVMVDNETAAQLRLWNTYCLTQLHFAVGNARPFHIQQRYLDHCPRILEHPAATLEDARVVAEIQLYLMTLRLQSNSSRMRLADLDYEEIERWKREWAHLFSGESSTLELSLWFCQTLLHRTAMRLQPRSDRLASEVLQTSRLIISRFLQIRYSTALSLVDQVYFIVGYAALNLCDFNLMDPLIEQVQMFLLHLSPNEDHIAYRFSCMVAEFKRRCGSAECNDPSSTVKGSPLSSYGDSRKMSMGQAPFMPPLMDGMIEGYGFEQLMPEVMPSSFPDGILNGMPVTGLAAYRSATL
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Can also use dATP, with lower efficiency, but cannot use GTP, dGTP or CTP.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Subcellular Localization:
Cytoplasm.
Domain:
The C-terminal UPF0157 domain is involved in the proper folding of the full length enzyme.
Sequence:
MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLVDAFGRDILLADGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIAAVSGDAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQASDQQRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKALRVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQDTEKTDARSTVGRYDHTDSAALWHKRVHASADPGRPTNVHLRVHGWPNQQFALLFVDWLAANPGAREDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEWADAVHWRP
The following text describes a protein:
Function:
Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection (By similarity). The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the 6 packaging RNA molecules (pRNA) forming a double-ring structure which in turn binds to the ATPase gp16 hexamer, forming the active DNA-translocating motor. This complex is essential for the specificity of packaging from the left DNA end.
Subcellular Localization:
Virion. Note=Present in 12 copies in the virion.
Sequence:
MARKRSNTYRSINEIQRQKRNRWFIHYLNYLQSLAYQLFEWENLPPTINPSFLEKSIHQFGYVGFYKDPVISYIACNGALSGQRDVYNQATVFRAASPVYQKEFKLYNYRDMKEEDMGVVIYNNDMAFPTTPTLELFAAELAELKEIISVNQNAQKTPVLIRANDNNQLSLKQVYNQYEGNAPVIFAHEALDSDSIEVFKTDAPYVVDKLNAQKNAVWNEMMTFLGIKNANLEKKERMVTDEVSSNDEQIESSGTVFLKSREEACEKINELYGLNVKVKFRYDIVEQMRRELQQIENVSRGTSDGETNE
The following text describes a protein:
Function:
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
Sequence:
MARLNSKAVAAAVVLAAVVLMMAGREASAALSCGQVDSKLAPCVAYVTGRASSISKECCSGVQGLNGLARSSPDRKIACRCLKSLATSIKSINMGKVSGVPGKCGVSVPFPISMSTNCNNVN
The following text describes a protein:
Function:
May act as a modulator of the olfactory signal-transduction cascade.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEDGPQKQQLDMPLVLDQDLTKQMRLRVESLKQRGEKKQDGEKLLRPAESVYRLDFIQQQKLQFDHWNVVLDKPGKVTITGTSQNWTPDLTNLMTRQLLDPAAIFWRKEDSDAMDWNEADALEFGERLSDLAKIRKVMYFLITFGEGVEPANLKASVVFNQL
The following text describes a protein:
Function:
Binds 16S rRNA, required for the assembly of 30S particles.
Sequence:
MTETIKKSGRGVNECKRCGRKQGLVRKYDIYLCRHCFREIAHEMGFEKYS
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MQSATFTVAPHVLEQAYKAIRTTPPEPKDLEQSAKLQSFMDAHFPTESDANITRRSLILAELRSIFRQWVKRVCMDKGVPEDMAADAGGQILVSGSYRLGVNEPGADIDTICVAPRHVTREDFFSSLKDIFLQHPKVSNLVAIEGAIVPILTFDYEEINIDLQIAILPRNSIPENLNILDDHVLVGVDPATEKSLNGPRVTELMIKLTPNRESFIGVLRIVRRWAKRRGLYSNKMGYLGGVNWCILVCFINQLYPTAAPSTLLLRFFMVLNNWKWPLAIQLCKTQDANLGLEIWNANAGHNRYQVMPILTPAYPSMNSSFNVSTHSLTVMKEEFKRGLTIVQDVLSKGGSEWGPLFEPSDFFAVHQHYLAVEVYTEKQDEEQAWCGFCESRMRKLVESLAYNPALCRLRAFTKKYPLNFVTGGEAPANEQSNGGTPAQPSKFGVCFYVGFDIDRRQLRSREVSIDSSVEYFKNNDLYRWNKRTATMDVRVTAVVWKSLPESVFEEMGGRAVARVVRREFMKKKKEEEKKAEEVAAPSPPPSGDEGVHSQEDGVEDLSSSQQAASLATEMANGKGSISQPGSPNPAADGSEATNGTDSVHSTPVKPKKTVSSASPEITGKRDRDGKAVVESGSPDGKSLGAADNSANTSTNGASAQGITSPPAKVVKKPVEQAAAPPAVSSPRKRRKMKITFAKLN
The following text describes a protein:
Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Subcellular Localization:
Apical cell membrane; Multi-pass membrane protein.
Sequence:
EVPRFDGWYNSLASPRRGAAGSWLVRLMPAHYWDGVYQPVQEPVRPNPRRLSRLLVGGPSGLPSTRNQTVLSLFFGYHVTFEMFDSRTPGCPPEFMNIPVPKGDPVFDPTATGKILLPFQRGPSDKDSGQNPSNPRTQVPYPDFNQKKVKEGVVIWTNTCFCFLKHVKVNSATAWIDGSSIYGPSASWSDSLRSFSGGLLASGSEWNMPRQAEGRTFMWSAADPCTGEHGPQGLYELGNSWANENIFTAAEGIIWFRYHNYLASRLQQEHPAWSDEELFQNARKIVVATFQNIALYEWLPAHLGDRELPPYPGYQKFVDPGISPELVAAAMRFGITMVPPGVYMRNKTCHFQEVVNLDGSSSPALRLCNSFWSRRSPNMKTSQDLDHLLFGMASQIAEREDNIVVEDLRDFMYGPLRFTRTDLVAVTIQRGRDFGLRSYTEVRNSLDLPPVGSFDDLNPELSSSDPKVKPTNQSSWEGQRLTNVLGVSLSRPRQLLRDIAELYNGDISKLELFPGGLLESSGSPGPVFSAIILDQFERIRNGDRFWFENRENRYVPLSQTFRANWGSRQSRTLSHCRLFTEEEIQKIRRTTLHHVLVAVTSAEATDLQKDVFFWKDGDPCPQPTQLKESMLHPCANATKLSYFDESKAGFTVFILLLFLFPAVSFLVAYMVAYHRKYRYRKFQRTRKAGDRTAEPAVGVAACEWQGHKKPLLPVRVEVSKGKVQVSECSGSLLRCFNLGSQDHLDVVLSDNRQRRAALLKGSKEYDLVLFFDDEARRAAVVEHLHRGSADVRVKEMAEEELLKEALTREQRAQVVETFIRHAFSKVLEIDKCDAGDMSDVSRKKAKEVLQCELTAGEFADALGLKPDSLFVDSMFTLADKDGNGYLSFQEFLDVIVIFMKGRSFLEISNCTLSKAQAEDGIRAMMQATGFDRKEKITWKDFHFLLQDHEKELQFAQLNVKGMEKRGQRRLSRDQRVSFICPASRWGHWFSIIFNCNDHFNTSCSMSAASARRKYTRFADRKSQFLPNVFVDPKREQYIRSPIRQKIQQFKRFVENYRRHIVCFIVVYGITAGLCLERCYYYGFQAESTGLPETSVVGVAFARGSAAAISFLFPYMLLTVCRNIITLCRETFLNRYVPFDAAIDFHRLMAMTAIVLAGWRSRYEGTHLRARKLTAASPPPVVHTLAHVVNIYIFSMSDLSILACLFPKVFLNNGSELPMKWSWWFFETVPGTAEVKMVNLSSHRKMMPVHPGCRKATRTPILVLLLLGLTGILLLFTLAFMYVFASRYFRRISFRGFWLTHCLYVLVYALTVVHGSYAFIQEPRFHIYLIPPALLFLLDKLISLSRKKLEIPVVRAELLPSGVTHLEIKRPQGFVYRSGQWVRIACLALGADEYHPFTLTSAPHEGTLSLHIRAVGPWTSRLRELYTQDSLQQLGAFPKADGPFGEGHQEWDDYEVSILVGGGIGVTPFTSILKDLVFKSSMKSRIRCPTVFFPNILKVYFIWVTRTQRQFEWVSDVIREVEEMDTQELVSVHTYITQVAEKFDLRTTMLYVCERHFQKVWNRSLFTGLRSVTHFGRPPFLSFFNSLQDVHPKVGKMGVFSCGPPGLTKNVEKACQRMNKRDQTHFIHHYENF
The following text describes a protein:
Function:
Reductase that catalyzes the conversion of GDP-6-deoxy-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (GDP-D-rhamnose).
Sequence:
MTQRLFVTGLSGFVGKHLQAYLAAAHTPWALLPVPHRYDLLEPDSLGDLWPELPDAVIHLAGQTYVPEAFRDPARTLQINLLGTLNLLQALKARGFSGTFLYISSGDVYGQVAEAALPIHEELIPHPRNPYAVSKLAAESLCLQWGITEGWRVLVARPFNHIGPGQKDSFVIASAARQIARMKQGLQANRLEVGDIDVSRDFLDVQDVLSAYLRLLSHGEAGAVYNVCSGQEQKIRELIELLADIAQVELEIVQDPARMRRAEQRRVRGSHARLHDTTGWKPEITIKQSLRAILSDWESRVREE
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MISNAIARRYAKALVQLGAEEGAVDRFGVELGQFTALLDGNADLASVLKSPAYRIEAKREILRDVLAKLNLSGTVSNFLQVLLDRGRIGFTPQIAHSYAVFADELSGIVRPVLTSAFPLDDAQVEGMKSALAKATGKRVELSAQVDSALIGGVVTKIGDKVFDGSVRTQLNRIQDILQKG
The following text describes a protein:
Function:
Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme uchl5 at the 26S proteasome and promotes its activity (By similarity). Plays a role in the transition from growth to differentiation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNRPPQDVEFKAGKAKLTGTTVTSDSRKGYLKFGVTPEGLTCVQWRPRDSSAYEDEFYFAPGESKFIKVPACKTGRMYYLNFSGSDQKEFYWLQEANVEGDAKIEKALKVIESYIPDDDDDEEMVVDTPPPTTTIKQEPPKNPTINEVSLSQPKPTTTPPPSATNLDFIKDLFSNLPTQPKQPQITLGKILTAENLIPFLRENPEIKKDLIQYLPEEYQKDENMINEVLHSAQFLQSIETLDYAIHEGHGPEIVSLLGYEPSIASQRGVEGFLTNIQEGTNKKKNNK
The following text describes a protein:
Function:
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function; Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
Domain:
The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.
Sequence:
MAKTRSQFTCTECGYENVRWLGRCPGCDAWNSFVEETVSPTPAAHRSPTPAAPRPRAAVALDAIDQSQHSRVPSGFGELDRVLGGGVVPGSLVLIGGDPGIGKSTLLLQTACRLSQAQTVLYVAAEESAQQVKLRAERLGVAAPGLFLLAETELEAVLSELESLKPGIAVVDSIQAVYLGALTAAAGSVSQVRECTASLMRLAKRTRITLFIVGHVTKEGSLAGPKVLEHLVDTVLYFEGDRFQSHRLLRSVKNRFGATHEIGVFEMGERGLAEVENPSELFLTSRDEPAPGTATIVACEGTRPLVVELQALVSPTSYGSPRRTATGIEYNRFLQILAVLEKRVGIPLSKLDAYVASVGGLDVSEPAADLGVAVAVAASFRDRIVDPHTVLLGEVGLGGQVRPVSQLELRLKEAFKLGYRRAIVPRGSAIAAPGMEIVPVSRVVEALVAALGGPQNPAPPVRHPAEETDALRPESEFRKS
The following text describes a protein:
Function:
Probable transcriptional repressor that regulates multiple aspects of plant growth and development, partly through brassinosteroid (BR) signaling pathway. Acts downstream of the kinase GSK2, a negative regulator of BR signaling.
Miscellaneous:
MISCELLANEOUS: The gain-of-function mutant ofp8 (T-DNA tagging) shows an enhanced lamina joint inclination at the maturation stage. Plants silencing OFP8 have a marked upright leaf phenotype and are insensitive to brassinolide.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Phosphorylated OFP8 shuttles from the nucleus to the cytoplasm where it is degraded by the proteasome.
Sequence:
MSGRSSRRGSFSLRQPPVVDIGCNCRRPKLFSIFSSSSSSSFRRGGSKPKSPNASSTSTTTAFTATTGGAGTATSTDSSWGPASFTTNSLFEEPAAAQQEQEQLETRRRRRQQRRRRRRAGATSFARGGDVGGHDDEQQQLQEQAPYRRVAKESVAVAVESAEPYEDFRESMVQMVVEKEIYAWDDLNDLLHQFLSLNSPRHHPLILHAFADLWTRNGLFSPPSPCQF
The following text describes a protein:
Function:
Probable methyltransferase required to silence rDNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNLEEAGIGEPKKTKKSKKARMKLKAAAAAAGGGGAGAGPGVAIGGVVPVVMKRKGGGAVESKKMSVMSGAKGNDDGDLGAKKKRNRKKRKKGVRDAGVEEVAEEGNNSHESDVVAATPPKREIAKPLSFLDKMRARLSGGQFRMLNEQLYTCKGEDAFELFQKDEGAFKLYHAGYQEQMTHWPRLPVDVVIDWLKARGPNMVVADFGCGDARLSKSVKNKVYSLDLVACDDTVIACNMANTPLEKGSIDVAVFCLSLMGVDYPRFLKEAHRVLKLGGFLLIAEVKSRFDPANDGASPTQFVDALKRLGFALVSQDEKNKMFCMFTFKKQGEKTGKKPIQWPDLKPCIYKKR
The following text describes a protein:
Function:
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Sequence:
MGPKLVLTNAISEYNPLPCSKYSTPKTGVFSIMPRRWIPYAELMRLDRPAGYWAFYWHFVIGLTLAANMSSPIPSPLTLVSLFLFFAVWVIILRGAVCTWNDTLDQDFDRKVSRTRNRPIPRGAVTTIQGHLFTLAQIALGTAMLLPLPLGCMYRAALMTAILLVYPLGKRVTDFPQVILGIAFGMSIFVCSAALDADPHPLLGTETDDLRLVTALCFYIASILWTAIFDTIYAHQDAKDDAKVGVRSLAVRLGDRTKHTLSVLAATQVMLLFAAGIACNFSAIYFAGSCIGTAISLAALLWFVDLRHSASCAWWFCRGSHLVGASMVAWLLGEYCVKP
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MTSPALDLSAVLPPPRLAQLARDWLAEDVPQFDPAGACVGSREVTATLLCKSPGSVLAGTPFFAAVFAELGCRVEWLFPEGASLGEEGGTFNVQQKGEPPCSGVTIHSLHLGGWEDLLHGQLWACGSVTRAVRDARAVCGFSSKIEVECGSEEEGREAALAGADIVMLDNFKPQALHAAARSLKQQFPLLLIEASGGVTPDSLSQFLSPNVDVISLGCITQGCPVVDFSLKVPRPPGAGPSAPRDGLLPHTNGATSPGDRGSSPSNDIITTLSSPMSRRDFAF
The following text describes a protein:
Function:
Displays RNA-directed RNA polymerase activity. The mRNA guanylyl transferase and mRNA (guanine-N(7)-)-methyltransferase activities are supposedly provided by cellular enzymes. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently three subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. In replicase mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals.
Subcellular Localization:
Virion. Host nucleus.
Sequence:
MSFHASLLREEETPRPVAGINRTDQSLKNPLLGTEVSFCLKSSSLPHHVRALGQIKARNLASCDYYLLFRQVVLPPEVYPIGVLIRAAEAILTVIVSAWKLDHMTKTLYSSVRYALTNPRVRAQLELHIAYQRIVGQVSYSREADIGPKRLGNMSLQFIQSLVIATIDTTSCLMTYNHFLAAADTAKSRCHLLIASVVQGALWEQGSFLDHIINMIDIIDSINLPHDDYFTIIKSIFPYSQGLVMGRHNVSVSSDFASVFAIPELCPQLDSLLKKLLQLDPVLLLMVSSVQKSWYFPEIRMVDGSREQLHKMRVELETPQALLSYGHTLLSIFRAEFIKGYVSKNAKWPPVHLLPGCDKSIKNARELGRWSPAFDRRWQLFEKVVILRIADLDMDPDFNDIVSDKAIISSRRDWVFEYNAAAFWKKYGERLERPPARSGPSRLVNALIDGRLDNIPALLEPFYRGAVEFEDRLTVLVPKEKELKVKGRFFSKQTLAIRIYQVVAEAALKNEVMPYLKTHSMTMSSTALTHLLNRLSHTITKGDSFVINLDYSSWCNGFRPELQAPICRQLDQMFNCGYFFRTGCTLPCFTTFIIQDRFNPPYSLSGEPVEDGVTCAVGTKTMGEGMRQKLWTILTSCWEIIALREINVTFNILGQGDNQTIIIHKSASQNNQLLAERALGALYKHARLAGHNLKVEECWVSDCLYEYGKKLFFRGVPVPGCLKQLSRVTDSTGELFPNLYSKLACLTSSCLSAAMADTSPWVALATGVCLYLIELYVELPPAIIQDESLLTTLCLVGPSIGGLPTPATLPSVFFRGMSDPLPFQLALLQTLIKTTGVTCSLVNRVVKLRIAPYPDWLSLVTDPTSLNIAQVYRPERQIRRWIEEAIATSSHSSRIATFFQQPLTEMAQLLARDLSTMMPLRPRDMSALFALSNVAYGLSIIDLFQKSSTVVSASQAVHIEDVALESVRYKESIIQGLLDTTEGYNMQPYLEGCTYLAAKQLRRLTWGRDLVGVTMPFVAEQFHPHSSVGAKAELYLDAIIYCPQETLRSHHLTTRGDQPLYLGSNTAVKVQRGEITGLAKSRAANLVKDTLVLHQWYKVRKVTDPHLNTLMARFLLEKGYTSDARPSIQGGTLTHRLPSRGDSRQGLTGYVNILSTWLRFSSDYLHSFSKSSDDYTIHFQHVFTYGCLYADSVIRSGGVISTPYLLSASCKTCFEKIDSEEFVLACEPQYRGAEWLISKPVTVPEQITDAEVEFDPCVSASYCLGILIGKSFLVDIRASGHDIMEQRTWANLERFSVSDMQKLPWSIVIRSLWRFLIGARLLQFEKAGLIRMLYAATGPTFSFLMKVFQDSALLMDCAPLDRLSPRINFHSRGDLVAKLVLLPFINPGIVEIEVSGINSKYHAVSEANMDLYIAAAKSVGVKPTQFVEETNDFTARGHHHGCYSLSWSKSRNQSQVLKMVVRKLKLCVLYIYPTVDPAVALDLCHLPALTIILVLGGDPAYYERLLEMDLCGAVSSRVDIPHSLAARTHRGFAVGPDAGPGVIRLDRLESVCYAHPCLEELEFNAYLDSELVDISDMCCLPLATPCKALFRPIYRSLQSFRLALMDNYSFVMDLIMIRGLDIRPHLEEFDELLVVGQHILGQPVLVEVVYYVGVVRKRPVLARHPWSADLKRITVGGRAPCPSAARLRDEDCQGSLLVGLPAGLTQLLIID
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MPLGIPSPDSPVHSVAMDRWRLIHSYLMTESITKHHLDSFNHLLDVTIPAIIKENSLLVVAKHPQFHLRIEKVDVKQVSQGSSKLSSSSAGSGVGLTPHECRQRNMTYAAPITIDVRCKASNKSSVQYYKEICIGYIPIMLRSNRCILTNKSRKQQAFLQECPDDPGGYFIVRGAEKSILLAEQMTMNRIVLGRNADGNVEVTVASNTTERKSRCAVLYKNKKFYLIHNKFNKKPIPIVTVFKAMGFVNDVTVLSLIGTDQLFLDYMSLSVQECSNDKIYTQEQALKYLADRIVVRTYTNANANFSASPVATAAKASVESARDCLAHFVLSHIPVVERLNLQQAAQHVLPQASAPAGSSVSAGADVGTATIGGGRSGSANATAKSVSGGGASTGASTIGSAASLTNTARFNWLPKAVYLATMIRRAILFDFGVIKGDSKDFVGNKKIETAGDLLELIFDDAFKTLLAHMVRKVDSVLRSDRNRGTDLTNYDIVSLVDPSIITRAFNSAISTGNWKIEKIGVDRVGVSQILSRLSYISALGQVTRLSSTFDKAMKSSGPRMLNFSQMGIFCPSDTPEGESVGIVKNLSIMARISKDESTDSISKLLMSIGVEDLASCWSGDTFSLGYGYMVFLNGTIKGVIAKDMLKGFIITLRTFRRRGYISYLTSFHFNDEHQAVYINCDSGRACRPLLIVENGKLMLTRSDIELLVDNQKCFVDLIYEGKVEYLDVNEAKNAYIAMDTKDLTPQHTHCEIESYTLLGYVVGLIPYPHHNQSPRNCYQCSMGKQASGAIAFNQLERFETAMFLLDYPQQPLTSTKILKLTGYERLPAGQNATVCVMSYSSFDIEDALILNRNAIDRGFGRCSIYRSVSTELNSIGSKSVDGIKDILLGPPKDHLKQYEGYHAIEDDGLCAVGAHLKTGDIVINKGRHITNIPGLSDGTEATASLIKAPESLKSPLETITYVDKVLVTTNGDGNMLIKVLTREPRRPEVGDKFSSRHGQKGVCGLIVPQSDLPFTSQGIVPDLIMNPHGYPSRMTVAKLLELLSNKSGCFRGEQTDGTCFRTKTDETFLAELYDSLRVAGFSYSGKDVLYSGLTGDVIPVYIFNGPIYYQKLKHMVKDKIHSRGTGPITMLTRQPTEGRRVHGGLRMGEMERDCAISYGASALLLERFMLSSDDFLAYVCETCGLFSYEKNGVLWCPTCQSGKDVVKIRIPYAAKLMIQELISMGVLVRMQLEDSV
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. Displays ATPase activity in vitro.
Miscellaneous:
MISCELLANEOUS: TsaBCDE are necessary and sufficient for tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification in vitro in E.coli.
Subcellular Localization:
Cytoplasm.
Sequence:
MMNRVIPLPDEQATLDLGERVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTLDNLMVYHFDLYRLADPEELEFMGIRDYFANDAICLVEWPQQGTGVLPDPDVEIHIDYQAQGREARVSAVSSAGELLLARLAG
The following text describes a protein:
Function:
Part of the Zra signaling pathway, an envelope stress response (ESR) system composed of the periplasmic accessory protein ZraP, the histidine kinase ZraS and the transcriptional regulator ZraR. The ZraPSR system contributes to antibiotic resistance and is important for membrane integrity in the presence of membrane-targeting biocides. ZraR is a member of the two-component regulatory system ZraS/ZraR. When activated by ZraS, acts in conjunction with sigma-54 to regulate the expression of zraP in the presence of high Zn(2+) or Pb(2+) concentrations. Also positively autoregulates the expression of the zraSR operon. Binds to a region within the zraP-zraSR intergenic region that is characterized by two inverted repeats separated by a 14 bp spacer. In addition, controls a regulon of genes of diverse functions that may be critical to maintain envelope integrity and cell survival under stressful conditions. The system has no direct role in zinc or copper resistance.
Subcellular Localization:
Cytoplasm.
Sequence:
MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAETPAVTASQFGMVGKSPAMQHLLSEIALVAPSEATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLDEIGDISPMMQVRLLRAIQEREVQRVGSNQIISVDVRLIAATHRDLAAEVNAGRFRQDLYYRLNVVAIEVPSLRQRREDIPLLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIASTPIPLGQSQDIQPLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MAAPSWIQSLLNHRKNVLASMHMKCVSTRLRKYGLRFEDLFDPMEDMDIKEALRRLPREVVDARHQRLLRAMDLSMKHQYLPDDLQAKQTPFRSYLHDMISLIKKEKAEREALGALPLYQRTIP
The following text describes a protein:
Function:
CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
Subcellular Localization:
Secreted.
Sequence:
SCNTATCVTHRLAGLLSRSGGMVKSNFVPTDVGSEAF
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MEDEYQLFASALEALMDNPLELIDRFMDISRDLAAQTAQETEEAMDSENFSNWELEARFWQLTATLSEARERFAETHNDDKMDVEGDSTTTDVFPFSSDASVLQQYKQTHLRVMETFLVNRWLQDNLTPSDHENIEIWGSKWMHTKSDIASKKRLGGGSVGNTSTLVSEMDADAPLRQKKPIAGEDAGYDSKLFRAIFDLIRRRQIKEASQLAEKTGNLSLKMAIGGLAAMEDTDVDPLDDAKAVGTTRTALWRRMCLSVAASPIGDYEKAVYGFLGGDVGTVLEVSDSWETQLLAYTNNMCSDQFEQALNDAHRVSSKTKALIPLVCPGHVSSMQDALELLAESSNIDVKRQAMNPIRTFVGAVINNTIETIASTSSDALRVAASTGQPNAVSESSIILRVLVHLLLALRHGYGGQKELDISHYNIISAYVERLAGEGHMELVPLYVSFLDSEDVTDQYSYYLANISDPSEREQQIHLANQYGVDIKACVKAAVARVFDESMSQYVIPDIIAVKFDNQVEDTDVRLYRAVEWFEDVKMWSETIDASVKLLRRFLLCGKVGAAREAGMRLNVPMLMQQYQADTLGADGNELDELVARELEQLYDLILFLDAVHSWEELMNSPRTHENNTQIAHKVTEIARQSDKLIHDWLIELLQQYTENQEIRPQDYTHLSHLRQIYIPYVILQLLSVYVRSRHIDPRFVTDAIELSVLVADDQQQIYRDFVDSGRLEEFLQCIFQASALMN
The following text describes a protein:
Function:
Creates a 3 um hole in the egg vitelline layer through which the sperm passes. Does not have enzyme activity. Species-specific interaction between the sperm protein lysin and the egg protein VERL exposes a basic surface on lysin that may dissociate the egg vitelline layer via electrostatic repulsion. Plays a role in ensuring species-specific fertilization.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome lumen.
Sequence:
MKLLVLCVFAMMATLAVSRRYQFVQHQYIRKAFEVALKVEIIAGFDRTLVKWLRNHGRGLNENQRKVLYFVNRRYMQTHWQNYMLWIVKKTNALGRPPVVADYRALGAEIGRRIDMGYFYNFLKNRVMIPKYLPYMRRLNNMRPEDVPVANRNPGK