lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for morphological differentiation of postmitotic neurons during postembryonic brain development. Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage. Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye-antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis. In the adult testis, maintains the male identify of adult somatic cyst stem cells. Represses expression and alternative splicing of transformer pre-mRNA, resulting in the production of the male-specific isoform of transcription factor dsx which ensures male-specific transcription of target genes. Plays a role in actin nuclear localization through its involvement in repressing the expression of the kinase Cdi. This maintains the cofilin/actin-depolymerizing factor homolog tsr in its unphosphorylated state which is required for actin nuclear import.
Subcellular Localization:
Nucleus.
Sequence:
MDPQQQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQQHMGDLSPLDSPTGRRSVRNSLSGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGMAAGGGMAAAANAAASSLSTLAASANIVDRCGSAGANIISGSAAGIGGSHSGGAGNGSGTVGIGGNGVGSGGGNNGPISLGSGAGAAHHLGGSTGILKQECDSLMHPGGSSSSSGMGYTHVPPIYRPINYEPPRKRAIVRSPYSEQEQRGSVLRDGSKSSECPSPINKPPYHRPSSSASSTAPTEADTMHSERASPQSSRYENHSPSTTAGNGNATSSLERIVKSERNNGSANEANDDDRELMDESTDNGAEDLRVKLENLKYSPPPPPNSNTSSTTPNTLLENLKADGTLSSNLAASIAPADMLNVWNATKMNNKNSVNTADGKKLKCLYCDRLYGYETNLRAHIRQRHQGIRVPCPFCERTFTRNNTVRRHIAREHKQEIGLAAGATIAPAHLAAAAAASAAATAAASNHSP
The following text describes a protein:
Function:
Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MASSPTPGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCAACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAMHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWHRARRRRTFCLLVVVVVVFAVCWLPLHVFNLLRDLDPRAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLLAWPRKIAPHGQNMTVSVVI
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMDPRQETCGDIVSTRKRRLEELYYVSLHPRYPQGLDAKQKLKQFQDQFDLTQNRLFDENKLPKAVEEPKPVPTLQTSTPDAGSSPELKRRRTSSIAQLSPTFSRTSLKTNEQQLQEMLLFLVPSNIPEPTTETKSLAELYYTTQTLPLSKLIPSAHKTLTTDSYHLALLEGKLAVAHARIEELKRAGKWGPRQPKRFQDPIRRKTHWDHVLDEMEWMSTDFREERKFKQAMACEIAFSVLEYHKYGKEACCVKTKPIKFLPEEINESEDTESKMDIDTSMPPPSINPVEVTNISAADSVTVVDYDTLLSQPRTLSSTEESEDKPEEPSTDSEEVVGGEVPKRPAAPKLPESSPFKLYASVDKLDPLSKALFDNLPVTTPPGSAVNALQVPYSDPLDNSKLAPVTHLLAAPPEQDDWWSVCLEDSPADEDPLPLRSNTRSTLFNSETMRRHVVIKAPQPPQTKYLDFRTPTMWLLADDSQLLRLVKEYSYNWDIVSAHMLPQKTYGFTANIERRTSWQCFERWFQLNPTFSLTDLRGPYAQAAQQWMAAAAKAQAQSKRRISPLGVSNESIQRGHRKLRWASMFDGIRKSMRKRETTPRPNPQPPRKSQLSESNKKDIASPLDLCKMKFEQDKNLAKAYAQQRMMPGQMPGQMPPVPSNIPANRQFPGQRPPPPQTAAQIQAHTQAQARAAAAASGHMQQRMAGVGMNRMPGQMNDQHQMMQFDRQRQLMEQQKMLQQQQQQQFMRTQGQVPPQPGQVQGQVNQNVQGAQVAAGQAGMAQRPAGQIPQGQMPAQQGQVPPGQAGNQAQMMRPNMRMRPGGPQAAAPNEHLNALIRQLQNQNPALSLEAATKLAHVQVQRFVQKQQRVARQAQGQTPPQGQMRPGQPQGQPSPQMRSGSSTPMNMQSPQLMNVQLQQQQQQRSASPGQSPAQQHAMLMRMNQQQQQQQQQQQNQGQTQGQNQGQGPSE
The following text describes a protein:
Function:
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Subcellular Localization:
Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes.
Domain:
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Sequence:
MSEVRPLSRDILMETLLYEQLLEPPTMEVLGMTDSEEDLDPMEDFDSLECMEGSDALALRLACIGDEMDVSLRAPRLAQLSEVAMHSLGLAFIYDQTEDIRDVLRSFMDGFTTLKENIMRFWRSPNPGSWVSCEQVLLALLLLLALLLPLLSGGLHLLLK
The following text describes a protein:
Function:
Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine. Necessary to ensure correct procapsid size during capsid assembly. Once the capsid is packaged with the DNA, the terminase complex is substituted by the connector proteins gp15.
Subcellular Localization:
Virion.
Sequence:
MADIYPLGKTHTEELNEIIVESAKEIAEPDTTMIQKLIDEHNPEPLLKGVRYYMCENDIEKKRRTYYDAAGQQLVDDTKTNNRTSHAWHKLFVDQKTQYLVGEPVTFTSDNKTLLEYVNELADDDFDDILNETVKNMSNKGIEYWHPFVDEEGEFDYVIFPAEEMIVVYKDNTRRDILFALRYYSYKGIMGEETQKAELYTDTHVYYYEKIDGVYQMDYSYGENNPRPHMTKGGQAIGWGRVPIIPFKNNEEMVSDLKFYKDLIDNYDSITSSTMDSFSDFQQIVYVLKNYDGENPKEFTANLRYHSVIKVSGDGGVDTLRAEIPVDSAAKELERIQDELYKSAQAVDNSPETIGGGATGPALENLYALLDLKANMAERKIRAGLRLFFWFFAEYLRNTGKGDFNPDKELTMTFTRTRIQNDSEIVQSLVQGVTGGIMSKETAVARNPFVQDPEEELARIEEEMNQYAEMQGNLLDDEGGDDDLEEDDPNAGAAESGGAGQVS
The following text describes a protein:
Function:
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
Sequence:
MKQEKLSLHDVLIRPIITEKALILREQRKYVFEVNPLANKNLVKEAVEKLFNVKVEKVNILNMKPKPKRRGIFEGKTRSWKKAVVTLKEGYTIKELEGEH
The following text describes a protein:
Function:
Required for renal function.
Subcellular Localization:
Cell projection, cilium.
Sequence:
MGASVLAMAARGGHTHTVKLLLENGAFVDDCEHACVSEGNTNTHCSAGSVQEARALLEVRALLAAAQHGQGAAVALLLDWGSDARVCHTGTGWSALMLAAAGGSLSVCQQLVERGADPDHTNVLGNTALEVALQLRRRDVQKYLDNITSVRPRPDDEKKRPDVFHALKLGNAQLVKEIVEQDAAQVDVCNADGASPLMMAAVSGQLEVVQLLVEKRADVDRQDSVHGWTALMQATYHGNKEVVKFLLSQGADVQLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMLVDKDKSKQRGKSALRRRASAGTPSPPEDKTGLKSWWNRMSNRFRRLKLTHTLRHGLSTNRLAPFPDAADVPLDATMRAEEGGAEVASPTAPPAGAQSTACSRTEDCGLNGTGSGKEDFLITTMLRNGAPLARLPSEQLKAVIPPFLPPSCFEPWSSERCGSLRDARSTHTHSQRPGRSSAGSDTASISRVVNRSIKFPSITKGPSPSNSGSYNSAHSSGGSNGVGGVNRHSDTHNRSGGSAADSVLSQIAAQRKRAAGLMDSRSPAVETPSPAHTPLPDSRPKLELQKRPQSGNSSRSKSTSPTLTPSPSPTPAHTPAPAHTPAHRPTGASADSQGSASTQQRSRSSGGSSSGTITDEDELSGILRKLSLEKYQPIFEEQEVDMEAFLTLTDGDLQELGIRTDGPRQQILAAISELNAGKGRERQILQETIINFQSSFGSSASTPRAATHTH
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVALAEKMNRAVTCYNFRLQKSVFHHWHSYMEDQKEKLKNTLLRIQQIIYCHKLSIILTKWRNRARLKSKKKEDELILKHELQLKKWKNRLILKRATAEESNFPEQSSSEGSLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAHCRNLQELNVSDCPTFTDESMRHISEGCPGVLYLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRGFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGITHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDRTFKALSTCKLRKIRFEGNKRVTDASFKYIDKNYPNLSHIYMADCKGITDSSLRSLSPLRQLTVLNLANCVRIGDMGLRQFLDGPASIRIRELNLSNCVRLSDVSVMKLSERCPNLNYLSLRNCDHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSKHKKLKELSVSECYGITDVGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSVAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNSNDPPRWFGYDREGDPLTELDNVTPSKGASELTVEKSTYSSEEQAA
The following text describes a protein:
Function:
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MFGSVRASLLNKRTVYSIQPISTRSYYRLFSCTRAIQSDSLTAIAVPIHRKSAAAYSTNTTAESTKGSAAIDNNSDVKHSHTGAAIDDPTEHDQDFIVAIPTGPMENPNYHKGTVWFDNIFPFHLGLLDPRTYWVKYYSKRFILHQRWSRLIPPWFPSGAEFQFREAEPNLKEGGLYLKFKYKGGTIEEAIEAIQAHVHSTGIRSIFNFGRINAFEVKGRPWVEDMVFRIPSRRLHVEFHGPDLSVEQLYREFRSFGRIMDITIQPSSIKDLPRFASVEFVNKRSATSARNCIHGELIDGTRVHIGYEKVKSSFSFWNWAISNLRISIPILLAVTAALSYIVFDPLRVFSIVSKLTDRFSFEKYTETAGAMWNGAQSSISALISATGYSSMDRSKIKNVRSTNQGWDERETEAKRLELHYKQAPETLVIVHGPKGSGKSELVRKSLEHHKKKLFIHCEDLVGQPEYVLITRLASQVNFFPSFGFMSQITTFMDAIITATTGAKAGLGTTKETEIRKILDCVTKAVTDLTLDQREARQKVLDELVDKNDEYNHSLSVPEIEYPVIVIDGFLGKENARGHFLYDMMAEWAAVTATQYKVAHVIFISDNPAAVREIGKVIPTKSVETFILNDATPETALAYVHRRLPELDTKSLWPSIEPLGGRLHDLDLLIQKIHAGLTPTDAFDDILHRSVTELRKIGLNEEADKSKHEWNDVQFWKIVQMLSKFDEVPFDHLVMHPIFKGDTQALSQMERNGLITLIHSHGRPYTIRPGKPIYRSAFTLMTQDTRLVSTMGILTAKQLISDEEKKVRVMEEEMCQLGLLQAHDGISTASFWTGGSNHIQSRMDYLASKLGDSAKKISNWNNEEARYRKELKLIE
The following text describes a protein:
Function:
Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Involved in NAD1 pre-mRNA processing and maturation of introns 1, 3 and 4. Necessary for mitochondrial biogenesis during early developmental stages. Essential for respiratory holocomplex I biogenesis in mitochondria.
Subcellular Localization:
[Isoform 1]: Mitochondrion; [Isoform 2]: Plastid, chloroplast.
Sequence:
MFRKRNLVLDLLRRCYIETLIPRGLWSRTISTFPKSALLATDNAEMASKETGMFSLAGELASLVEESSSHVDDDSKPRSRMELKRSLELRLKKRVKEQCINGKFSDLLKKVIARPETLRDAYDCIRLNSNVSITERNGSVAFDSIAEELSSGVFDVASNTFSIVARDKTKEVLVLPSVALKVVQEAIRIVLEVVFSPHFSKISHSCRSGRGRASALKYINNNISRSDWCFTLSLNKKLDVSVFENLLSVMEEKVEDSSLSILLRSMFEARVLNLEFGGFPKGHGLPQEGVLSRVLMNIYLDRFDHEFYRISMRHEALGLDSKTDEDSPGSKLRSWFRRQAGEQGLKSTTEQDVALRVYCCRFMDEIYFSVSGPKKVASDIRSEAIGFLRNSLHLDITDETDPSPCEATSGLRVLGTLVRKNVRESPTVKAVHKLKEKVRLFALQKEEAWTLGTVRIGKKWLGHGLKKVKESEIKGLADSNSTLSQISCHRKAGMETDHWYKILLRIWMEDVLRTSADRSEEFVLSKHVVEPTVPQELRDAFYKFQNAAAAYVSSETANLEALLPCPQSHDRPVFFGDVVAPTNAIGRRLYRYGLITAKGYARSNSMLILLDTAQIIDWYSGLVRRWVIWYEGCSNFDEIKALIDNQIRMSCIRTLAAKYRIHENEIEKRLDLELSTIPSAEDIEQEIQHEKLDSPAFDRDEHLTYGLSNSGLCLLSLARLVSESRPCNCFVIGCSMAAPAVYTLHAMERQKFPGWKTGFSVCIPSSLNGRRIGLCKQHLKDLYIGQISLQAVDFGAWR
The following text describes a protein:
Function:
Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL10, negatively controls glycogen accumulation under favorable growth conditions. Involved in phosphorylation and negative regulation of glycogen synthase GSY2. Also has minor GLC8 kinase activity.
Miscellaneous:
MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MANDQDPNKSLINDALTRSMSEFYDDDDDNDSDMCRANDEGEDVFDLPLKVGVSQSRNFSEVNDVLDPLSSLHGPSKKVRFEQQKQQQQHQQLHNDFNTDFNLKSPSSKKMGVEQLIQSANEINDYLANNIDKVNSFNSELLSGSGKLPGRVKSDTATQGTGRLDSMSNFALSDTELDNDDDNYLLDPLANASSTTPTVEHHGYSLLDKALSTSDKEKIYTNKVNSNSQIDTDNHSHESGNTTNNETDENESSEILDYTKFDSFPYPPSSAPNGEPPDLKVLSIECEQENEKELRRISLLLDHYESIPKIPELSDDEALSKFRENIELILQLSKKINDNANTLAISSEDPQKFVNFVMKNPPSLSFRDFIDRIQNKCMFGAVVYLGATYLLQLVFLTRDEMDGPIKLKAKLQEDQAHRIIISTIRIATKLLEDFVHSQNYICKVFGISKRLLTKLEISFMASVNFDGLMITCEKLEKTLHILDDTRQALGNT
The following text describes a protein:
Function:
5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
Miscellaneous:
MISCELLANEOUS: Present with 3310 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MSMSNIVVFGGDSHPELVTKICENLDIHPSKVELGKFSNGETNIALRESVREKDVYIIQSGCGQVNDTFMQLLILISACKSASASRVTAVMPYLCYSRQPDIPYTAKGAPIISKPKENYTFESHPGTPVSSSLMTQRPGAESSLKSLDSAIRSTINLENPQPIRTPNSSATANNNFDIKKTLSFSRIPMIPGGKLQNTSNSTDAGELFNAQNAGYKLWVVQAGTLIAHLLSAAGADHVITMDLHDPQFPGFFDIPVDNLYCKPIAQNYIQHRIPDYQDAVIVSPDAGGAKRATAIADALELSFALIHKERRSQLLKGPPDATLTSGGSLPVSPRPLVTTLVSSQNTTSSGATGVAALEMKKTTSTSSTSSQSSNSSKFVQTTMLVGDVRNKVCIIVDDLVDTSYTITRAAKLLKDQGSTKVYALITHGVFSGDALERIGQSSIDKLIISNTVPQDRTLQYLGKDRVDVIDVSCIIGEAIRRIHNGESISMLFEHGW
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MTSSRKTSSAYIVPFFPHQKMPVINIDDLTEKDKAKMEVEQLKKEVKLERQLVSKMCEEIKTYIEDKSGEDPLVKGIPEDKNPFKEKGGCVIA
The following text describes a protein:
Function:
Regulates planar ovule integument development by suppressing aberrantly oriented growth. Maintains planar growth of integuments by repressing the developmental regulator and transcription factor KAN4 which is involved in the control of early integument growth and polarity. Restricts growth in stamen filaments, petals, and cotyledons.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
METRPSSSSSLSPATNLNLDRLKVLKLLGKGATGTVFLVHDSVSDSSVSSPFALKLVDKSSASSLRRARWEIQILRRLSDDTNPNPFLPKLLASSESSEFIAWALPYCSGGDLNVLRQRQNDGVFSSSVIKFYLAEIVCALDHLHTMGIAYRDLKPENILLQESGHVTLTDFDLSCSLNKPTRPEFYHLSDPEPDPNPESNLSHNKKSLRIFRQKKKKTKSARVNPITRRRLSFSGGERSNSFVGTDEYISPEVIRGDGHDFAVDWWALGVLTYEMMYGETPFKGRNKKETFRNVLVKEPEFAGKPSDLTDLIRRLLVKDPTKRFGFWRGAAEIKEHAFFKGVRWELLTEVLRPPFIPLRDDGDLTGKVTEESGFGIKEYFEKLKTPPLPLPHECSENNPFVDF
The following text describes a protein:
Function:
In vitro, catalyzes the formation of 1,8-cineole from geranyl diphosphate (GPP). Can also accept neryl diphosphate (NPP) as substrate to produce 1,8-cineole.
Domain:
The Asp-Asp-Xaa-Xaa-Asp (DDXXD) and Asn-Xaa-Xaa-Xaa-Ser-Xaa-Xaa-Xaa-Glu (NSE) motifs are important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
MPAGHEEFDIPFPSRVNPFHARAEDRHVAWMRAMGLITGDAAEATYRRWSPAKVGARWFYLAQGEDLDLGCDIFGWFFAYDDHFDGPTGTDPRQTAAFVNRTVAMLDPRADPTGEHPLNIAFHDLWQRESAPMSPLWQRRAVDHWTQYLTAHITEATNRTRHTSPTIADYLELRHRTGFMPPLLDLIERVWRAEIPAPVYTTPEVQTLLHTTNQNINIVNDVLSLEKEEAHGDPHNLVLVIQHERQSTRQQALATARRMIDEWTDTFIRTEPRLPALCGRLGIPLADRTSLYTAVEGMRAAIRGNYDWCAETNRYAVHRPTGTGRATTPW
The following text describes a protein:
Function:
Involved in cell cycle. Involved in formation of flagella, regulation of flagellar length, and formation of median bodies during interphase (By similarity). Regulates flagellar length in all eight distal flagellar tips by promoting disassembly of the microtubules. Disassembles microtubules at the distal flagellar tips in a length-dependent manner in order to maintain different equilibrium lengths of the four flagellar pairs. Regulates interphase and mitotic microtubule dynamics. Regulates microtubule disassembly dynamics of the dual mitotic spindles and the median body.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum basal body. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes and accumulates in a length-dependent manner to the distal regions of flagellar tips. Amount at the distal flagellar tip increases during de novo assembly possibly as a consequence of its transport along the flagellum. More of it is present in the caudal flagellar tips than in the longer anterior flagellar tips. Amount decreases sharply immediately proximal to the flagellar tip indicating that it does not undergo directed retrograde transport on the axoneme, but likely diffuses from the flagella tip toward the base. During diffusion, it may be recaptured by anterograde intraflagellar transport (IFT) trains to sequester it to the tip region. Localizes to basal bodies in interphase (By similarity). Localizes uniformly to the median body and unevenly at distinct regions of all eight flagella, primarily localizing to the distal flagellar tips, in interphase. Localizes to the cytoplasmic axonemes in interphase. Localizes to the ventral disk in interphase. Localizes to the plus ends of interphase and mitotic microtubules. Localizes to single spots on chromosomes during mitosis. Localizes to the plus ends of microtubules and kinetochores in anaphase spindles. Localizes to the growing flagellar tips of the posterolateral and ventral axonemes during mitotic telophase. Also localizes to kinetochores during flagellar duplication.
Sequence:
MSDLVYQWLESANLQQYYPAFEQQGITPQRFITITIQDYGALGIQALPDKQKLFRLITTLKSRENILEQQPSAPNTGATPQSVPSSHVSPHVAQGDRFVGDKQKQNDIQQAQDMSLYESYDGGYEPPYVSAQGSGPANGDDYVIPTIPYHPNAPNPPNPRGIPTVNRTVVPPVDLFLNQIQSRIRVVIRKRPINPKELSQNQRDVVTADGWNQVSIHEPKVKVDLTKYTDLHTFKFDHVFNEQSDNQEIYQYAAKPLIRSVFEGKNCTVFAYGQTGSGKSFTMMHKDNGIYVLACFDILEYLRVYNGSQGNNSKFLVPVVSFFEIYGGKLFDLLNNRQRLQALEDGKGNVQITGLTEKQISSVDAMLNLIDSGLTLRAVGATGANADSSRSHAILQIALKYTKSGKEYSRISFIDLAGSERASDVQNSDRQTRMEGAEINKSLLALKECIRAMDKSNDSKSGAHIPFRGSKLTMVLRDSFIGNSQTVMIANISPNDKSCDNTLNTLRYADRVKELQHGKGGIIKFNVLKMGQNAADVILGTARDDENDVYKAGIVGVNAAPSQQARVPPASQAPITARQIQQNLPQPHYNPNYNPPNSKPAFEPRVETTDEDDMVRTHCDLVDSIYEQEDLIVRAHRRQVDSMMQLVKEEVALLHAIENDQVSIDDWLVKLSDILSRKEEAITTLKGNLSAFKQALQKEEELSHSIDLNKARKK
The following text describes a protein:
Function:
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm. Note=Associates with the nuclear pore complex cytoplasmic fibrils.
Domain:
The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
Sequence:
MATDSWALAVDEQEAAVKSMSNLQIKEEKVKPDTNGVIKTNATPEKTDEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPAERYPQCLCLSPTYELALQTGKVIEQMGKFHPELKLAYAVRGNKLERGQKISEHIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNIIKLKREEETLDTIKQYYVLCNSRDEKFQALCNIYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMVVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN
The following text describes a protein:
Function:
Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. P-granule component involved in germline development. Together with the P-granule component pgl-1, is involved in the formation of P-granules. Together with pgl-1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules. In vitro, binds mRNA; this interaction is required for the formation of liquid-like droplets that resemble P-granules. Most likely recruits pgl-1 into P-granules during autophagy. Associates with adapters such as sepa-1 and is required for the accumulation and degradation of P-granules by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. In addition, may act redundantly with pgl-1 to protect germ cells from excessive germline apoptosis during normal oogenesis and development of the two gonadal arms. This may in part be through regulating the localization of sir-2.1 which is involved in germ cell apoptosis. May protect somatic cells from excessive apoptosis during normal development.
Subcellular Localization:
Cytoplasmic granule. Note=Localizes to P granules in germ cells at all stages of development except in spermatogenesis. Localizes to the germ precursor cells Z2 and Z3 in embryos. Co-localizes with pgl-1 in P-granules, but localization in P-granules is not dependent on an association with pgl-1.
Domain:
The dimerization domain also acts as a hinge; changes in its structure probably impact oligomerization and RNA-binding; The RNA-binding RGG-box is required for the recruitment of some P-granule components such as pos-1 and probably mRNA, but is dispensable for granule formation.
Sequence:
MEANKRQIVEVDGIKSYFFPHLAHYLASNDELLVNNIAQANKLAAFVLGATDKRPSNEEIAEMILPNDSSAYVLAAGMDVCLILGDDFRPKFDSGAEKLSQLGQAHDLAPIIDDEKKISMLARKTKLKKSNDAKILQVLLKVLGAEEAEEKFVELSELSSALDLDFDVYVLAKLLGFASEELQEEIEIIRDNVTDAFEACKPLLKKLMIEGPKIDSVDPFTQLLLTPQEESIEKAVSHIVARFEEASAVEDDESLVLKSQLGYQLIFLVVRSLADGKRDASRTIQSLMPSSVRAEVFPGLQRSVFKSAVFLASHIIQVFLGSMKSFEDWAFVGLAEDLESTWRRRAIAELLKKFRISVLEQCFSQPIPLLPQSELNNETVIENVNNALQFALWITEFYGSESEKKSLNQLQFLSPKSKNLLVDSFKKFAQGLDSKDHVNRIIESLEKSSSSEPSATAKQTTTSNGPTTVSTAAQVVTVEKMPFSRQTIPCEGTDLANVLNSAKIIGESVTVAAHDVIPEKLNAEKNDNTPSTASPVQFSSDGWDSPTKSVALPPKISTLEEEQEEDTTITKVSPQPQERTGTAWGSGDATPVPLATPVNEYKVSGFGAAPVASGFGQFASSNGTSGRGSYGGGRGGDRGGRGAYGGDRGRGGSGDGSRGYRGGDRGGRGSYGEGSRGYQGGRAGFFGGSRGGS
The following text describes a protein:
Function:
May play a role in controlling magnetite number and size (Probable). Coexpression of mamLQRBIEMO in a deletion of the 17 gene mamAB operon restores magnetosome vesicle formation but not magnetite biosynthesis.
Miscellaneous:
MISCELLANEOUS: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)); MISCELLANEOUS: Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
Subcellular Localization:
Magnetosome.
Sequence:
MIWTAVIKGSALMTFVQGAMALVDKVFGEEILPHRIYSSGEAAQLLGMERLQVLEMVRAGTIKAKKVGDNYRILGSNLVEYMNR
The following text describes a protein:
Function:
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
Subcellular Localization:
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Sequence:
MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLYVHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLIEYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKVLKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFLAVLELMKNQLVLIEQEHNFSDIYITGSESIHGA
The following text describes a protein:
Function:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular Localization:
Nucleus.
Sequence:
MPPILKGDVPETYVVILPKCVENSTLTVFQLPHPSNNRSKSPVRLFIHDGLVYQLQTQKFSRGCPYNRADDEVNERYHYTADGQAYKSAIYLNEEDPSQSLVLESGEFDYHTKYDLAFSLCRYYYRNNVVNTEAECLEPSRQAVRPSSNFLAVRDFHDELVSVDNPNWSHVPLDVLEAALLRVSDVVEEAGDRYFRISPQRITQWLSTKVERMLPVFPSSLPLPSGIPDEYLRDVKTAWSTNLLLSLIPQLAYWELRNYEGENLNIKQAFARQDKYKTDVLEKQKENDILIKGAMSVGLQQDVKREGPPRQTTNLKSTVKKKVATGKGAIDSFFKKR
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Can also transport lithium. Contributes to the survival of V.cholerae during the stationary and exponential growth phases in a saline environment.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSDMIRDFFKMESAGGILLVIAAAIAMVIANSAMGEGYQAFLHTYVFGMSVSHWINDGLMAVFFLLIGLEVKRELLEGALKSRETAIFPAIAAVGGMLAPALIYVAFNFNDPAAIQGWAIPAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVVVIIALFYSSDLSTIALTIGFIMTGVLFMLNAKHVTKLSIYLVAGLILWIAVLKSGVHATLAGVVIGFAIPLKGNKGEHSPLKHLEHALHPYVAFAILPVFAFANAGISLQGVSLAGLTSMLPLGVALGLFLGKPLGIFSFSWAAVKLGVAKLPEGINFKHIFAVSVLCGIGFTMSIFISSLAFGQANEAYDTYARLGILMGSTTAALLGYSLLRLSLPLKKA