lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, cilium. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus.
Sequence:
MSANRQNEISALGKAAAHVPDLIVYGDFSQEVPFIESFDGVLLFVDISGFTALTEKFSTDTKMDRGADELTQTLNHYVGDIVEEVLVFGGDVLKFAGDALLALWKVERCHISDIITLAVKCSFSIQQEYGVRDTEVGLELRVKIGLSAGHISKVILGDNKYRYFLVIGRAVDEVRLAQNLAKASEVILSPNCWELCDRNLIEVDRIPDERAVKVSVSSSQNTVLRNASILAPNEELEKNLRKFVMRNILRKIDDNQPLEYLSELRPVTIVFVNLQFDDSANTHHLCKAIQDAYTMIIRVIHPLSGKINKLFMFDKGCTLLCIFGLPGDKQADESANALDSAHEIHAFCSRALMKVKIVSIGVTSGPVFCGVVGHRVRHEYTVIGRKVNLAARMMMYYPGIVTCDAITCAKSKLPLHFFEELPLIEMKGVLNPGTVYHFLGVSEKAMIYKAYLTRERSEYYPLLGRKKETDIFENLLMDFKVIRKSHIIMYEGPMGYGKSQLMAEMAYLGQWAGQKVVAMELAKINMCQNFFTIRTFMAMFLGIDTCKTYDARQYILLAKIHDIINEEYLCLLNNLFHVKFPTSEKVCQMNKDARNEEMERILVKILENAVEKEILILVIDEAQFIDSASWDFLDNLLKKVPIFIVMSSSPIKSKGRLPCQTAAKILNSPDTTYIHLRELTPSVIIQKACQDLGVVTIARELETFLIQRSHGNPFYCEELLRNLHLNNVLQFHLVEEDEEKEDEWDSLFSKLLIVNWSHGIAFCIRNPQLDNMNPSEQMVVKCASIIGATFTTDLLHYILPEWSKMKMYQTLAALVDSNIFQCFIERKDLKANSIPFLSKCGTLTSFSLSDIGIAVSNRLNQEERVMGCKIMTFCTPLLQEAAYELWLKNQKKALHLKCASYLEKHAHRCKCCGGGDFISFHRFAVEGMLENIHTWEAKGEQVIENELNQTVLMLVSETLKKLEPSKREGTSLSRMDEIIFLTGMSKKNDKNVACCECEEIVESVIVPLSQHCTALGNYTRAFYYLLECASGYVHLSNNYMHKLLCYYISYVLQVSYNMGQINLAKKLLKKALSLLNRSFPITIVGAFFMSMVETSRHLSHQKKQTFWQISSGKQKKLAVLHLQGNCLSLLWQLFSLDLARSSKKFSRLAALMKVNCAEESHDDSQIISSYMEFSLCCQLLGYQHDWMKYELMAIRRSSFLRVVGEGLLIITKLASSLAYMKLCLGNLPLAIQLGSEHETVKFQLCSSLPKLTRDISSIFHYFFCRFQDAVQVLSWLEELSIQHNNIIGQACFISSCLNVMLYAGFSFRSFDHCLEFVLANETNCILMSQNNIMLGLYSSLAIWFARIQEWSNFVQPFEQARRLMRRTSASLYANHGFCKFVECEVLLLRKYIEEKPDKARDLRNKVLKNFDLVMAQCSTSPIFYARVYHLKAYVQLMLDHDENSQNFLENAFQNSELYGNFLEQSWLEISKQGRREGKLQFSLPTPSWLSHREGCGP
The following text describes a protein:
Function:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
Subcellular Localization:
Cell projection, filopodium. Cell projection, microvillus. Cell projection, ruffle. Endomembrane system; Peripheral membrane protein.
Sequence:
MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKMGQFIRLVESGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDERLQKLGVQIREELLRAREEPGQAEAPAAAEALGAGGDNEPQAAAPEPREAEKSPPERGDLGAQPGWGGKLSLPWWWQLRELRPRLCTMKKGANGYGFNLHSEKSKPGQFIRAVDPDSPAEASGLRVHDRIVEVNGVCVEGKQHGDVVCAIKAGGDETKLLVVDKETDEFFKKCKVIPSQEHLNGPLPEPFTNGEIRKENSREALAETASESPRPALARTTSSDTSEELNSQDSPKKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL
The following text describes a protein:
Function:
Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from vacuoles/endodomes.
Subcellular Localization:
Endosome membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MVSLDDILGIVYVTSWSISMYPPIITNWRHKSASAISMDFVMLNTAGYSYLVISIFLQLYCWKMTGDESDLGRPKLTQFDFWYCLHGCLMNVVLLTQVVAGARIWRFPGKGHRKMNPWYLRILLASLAIFSLLTVQFMYSNYWYDWHNSRTLAYCNNLFLLKISMSLIKYIPQVTHNSTRKSMDCFPIQGVFLDVTGGIASLLQLIWQLSNDQGFSLDTFVTNFGKVGLSMVTLIFNFIFIMQWFVYRSRGHDLASEYPL
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell inner membrane. Cell membrane; Single-pass membrane protein.
Sequence:
MKKLLSACLILFTVVCSAYAADEKEAAPAAEYAYYGFEPEIVTNYISNRKKLGFVKISVELMVKSPDDLVIVERHDPLLRAAIIEVLGNQAEEKVKSLTGREEIRRECFDMVNNLLTKEAGKPLVVNLLFTSYLYD
The following text describes a protein:
Function:
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MAFRNWFSLPAVRADDEEDLVDPQAVLREKCQAKGHIESLYNKYQECNDRVNGRSKTTETCIEELFDYVAELDHCVSHSLFTKLK
The following text describes a protein:
Function:
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Sequence:
MFNRNSNIENLENKLSGINESITNGKLDISKKSQFFIDQLMKFDTSSKRLDIVASFISNKKYSTFQELKQSYQDQMSRSICGKVWNSESHIYKCLDCQIDDNCAICIDCFEEDKHVGHRYRLIVGFNGCCDCGDFSAWKKEGCCSVHVKREGQEKGDDTKVKQPLPESTEFIMIDIFLTRILTDLSINRYTVTTESLLDILNKFIDVLGDDFTLLITNFISKLNQSPLIITLPKRISSSASVILPKTTTSSSTTTYKVTLTERHIFNGLSLFTSKGIPTLEKFVISLFISTDFRDTLAMSIAEAFSCPTYDSSLTVQLFTVDSTALKIVETGKFKYMLNTFLRSLLNEEDDKDKIILLREGEVIEQVLEEDHNYYDDDDDEEEEEEGQQENEKEEERVDNGVNQEVQQQQLTQQQEGAVPMSTSPPPVNNNSTTTSNKTKQNIYQILDPKMTKFVARLYFKSLISIAYILKTKSSFLWLIDNPTLLYKSLLSLALAQGMNPNTRLTTRHIEYEDQTWVHCFYFEIYLTKYITHAIFDQFKDNEKLITKESQIVNIRDFIFNHIIDYYKYESVHEVGGNTTSNSDVSGYKNTIRLPFKESDSGDKDIIKWKMGIRDTVIPEYRVSKQPVSIHIPLHRAFTSAVYFQSIKFNTTPEEVLKILSKKNSIYQSVCSAVIEHVFRAFSMSFQFLAGMWVRNGDPMKNQIANYFRVKDQNSTVDLYLMQYVSLAMEPKIFFSQFLDRCELCSWFYLDGHIFIDEQNQTSKNNNNNNKNNSNNNNNNNNNSGISIVNEVTNKSPSVSPLSSFTSAVQSTFSSTFSSTSSTPNHQHKSESDRANTIIAENFLETIIWLFTDRTKLANLEGSNQLLRKELIHILSVKPQKFSDIYSKVSNQFQDSLELDSILRDISTFSNATGTESGIYQLKPSSWNEWDYYYPYHKKTDQQKSEENYVIQCKREKKSLIEQNTKPIVPLEEVLPAFTGIERILQCEILHTIIFAIIHNSLTGSVKSSETLLSTALHLLYLAIDTYYLNSKNQIFKKYGFHRSTMETKPYPLPHSENPRTYRSPLGLAHDILDIGFTLDNILNNMVQPIKQTTSFISVLSPPTITLLSLLKQMQSTPKFEIHFGSISRILSHPTLVHSLNINNDNSRNKREILNTAGDQTVYANRIRNTPTISTTPTIPTTSTTSTTSTTPTIPTIPTTPTLPTTSTTSTTSTIPTTTTTTTTTTTTPITTSTNPLKESTSPVSSQMKEIAMKRQKELMRLMQEQQKKFMKTNDIEDKKSEKDENEFDGVDNKKKIKNSTDDIMQTTGEVDIFNFQISDEQQQQEEEEIDFGSCAICRDELDVTKTQHPFGYVASLQKNSLLPYCPLLVSDPLMSNEDRRRAKLIKNSSLEETKDIDQNAPLYVDVNDTNGSFITFCSHLIHINCLNTLNDNSAGGVLRNQNRLKNFSCPVCRRSSNIIVPYSKQKVSSSIRTRVNFDNTIESIKQSFNNWFTQVYNDSTTTTTTTTTTTSDQVSTELNELNKSSSSLLSSSSSSSITSGTNKTTTTQEYDQFIKTVYDSTTIQDLSF
The following text describes a protein:
Function:
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MVAADTSHPYLETTMDLSTLPDFCQSISAQWLAQTDAAVANEVSKGISIEQFLTLLSAAAVLILPFIVGNFLAKSLKMPTYGTRFGFILLAITASGVTLANKLPSLGIDLSGGTILVYELDPEKQAAVIESGGQRITSEDLVGPLTRRINPAGTQEIVIRPYGEQQIEIIIPEKDPDAVERIKGLVEEAGQLRFAILANQFDHQTLINEAIEQAESTQPGVATKDMVGSPEDSLYGIWARIGFEEKETDGIRPMLVPISGALARNPRTGAILNVPAEARVGDETVSVARWLQTQDFDNIEVLMVINPKLDILGEDLAYAASTFDEKGAPAVAFTLTDMGSGRFRALTTNNAPDGSRTRQLGIVLDDELLSAPSIQEPMNKNGRITGNFTRDQVDSLVQILKAGQLPATVTKQPIAENEVGATLGADTRTKGLYSIAISLGLVLVFILVYYRFAGVVACIALIMNMAMILATMVFINQPLTLPGLAGLVLTVGMSVDANVLIFERIREELSKGAKARMAIRNGFARATTTIIDANLTTLITAIVLYAIGTDQIRGFAVTLILGILYSMFTAIYVSRTIFDLAERRGFLSLGMSDGVNSIRSAFAGGGQFNFISKGKVTLTMSAILVVCGLAALFARGQSILDIDFAGGSSVQFRVDEPTKADEIREIMNKAVAASDNSSVQFTVNGVSMEGTEEGTVFKIDSSVERVEDLKRVIQEGFAASESVGLVTYSVDITPADLPGATPEDAAPEAEETSSSDPAEPSETSTSQWQSVDNGVMLVVAQADDDEEAAAEETNAEEAPETEADAAESDGPKMEAREFPGLAFSTSDISLGIKGADGVAVKNEEGLVDSIVAAAESAGVPINKDGIVVKPLGEDIEAWSPGSTLAFPKWRVQLPLGGDNAIKVMAEMEKQLDSDPVWISSSAVGARVAGDMISRAFGALFASLLCIIGYIWFRFQRVIYGFAAVVALLHDVAITLGAIAISYWVADALGFLLIDPFKISLTVVAALLTIIGYSLNDTIVVFDRIRETKGKAPRLTGEMINTSINQTLSRTLLTSLTTLIVVVLLYAFGGEGIHAFAFALVIGVIVGTYSSVFVASPVLLWLVERAEKKAANA
The following text describes a protein:
Function:
Activator of G1-specific transcription factors, MBF and SBF. Promotes both the timing of G1-specific gene transcription and cell cycle initiation. Associates with SBF- and MBF-regulated target promoters and this binding is maximal during the G1 phase, prior to maximum budding. Affects cell cycle initiation by advancing the timing of transcription of G1-specific genes. Overexpression advances the timing of SBF-dependent transcription and budding. Depletion delays both indicators of cell cycle initiation.
Sequence:
MDKSMIKKRGRPPITKDYPNPLQSPMAHSSMQVQKQGPHSFAKPLMKVGQSSPSPNKRRLSIDHHHNLAATTRKGRYRGVLLSTPTKKSSTNGSTPISTPSSNDSYNNTVFSETRKTFLQSSPPIMTSSPAFQKKNDYMFPSQEQFKLSLTITESGKAVIAGSLPFSPSSKSSHLMNNNNKKIMQNEKIHKGSKKNAPKFEKRRILSLLKQMKNEKYCDTDTLPEAPPAKPSRSDIIDTELPTIIETSASPIGSARNNNILLSQPPQSPPSSAQLKPPSTPKSSLQFRMGFTPNVALNSVSLSDTISKSTNAVGASNNNNQNGNSISNIADANTLLTLTNSPGVFLSPRNKMLPKSTTASNEQQQEFVFKFSSGDPLLLTDDADGNWPEMLFNVSNTPRRQKCFNTPPSWINFGSPGLFSPPRSSNVMVNGTTVATASDSGNVHRQLQAQLEAQVQVQSQSNSPTQRQQQQRQFQIPPPHINMNSSPPQINIASPPHQSMSRVSSIYFNKEKTTTGVANMLGNTKSENLQPPANLFTAAHGPSTPRNQEFQLPTLIECTPLIQQTMNGSLGTKYIPGTSISNSATPNLHGFPVGTGKAPSSFDDSLKQNPYSNKQDDARTALKRLIDDQ
The following text describes a protein:
Function:
Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.
Sequence:
MSNQIYSAKYSGVDVYEFIHPTGSIMKRKNDGWVNATHILKAANFAKAKRTRILEKEVLKEMHEKVQGGFGKYQGTWVPLNIAINLAEKFDVYQDLKPLFDFSEENGDAAPPPAPKHHHASKASSAKAKKAGRSVSSPAMNDSKTRASTRKANTPSSNDITSDSGAVVNPVVTRRRGRPPNSTLTNKRKLGTGLQRSQSEMAFLKPEIPNDLNSNDIANIQQVNSGDLLRNEKIQKNIQLKEIDLDDGLSSDVEVQETDTFQPNHQSSLLGAEGHELRNNDSPLSPSSSSSLPTSPANLNDSNPFDQRLGGGGTSPIISLIPRYSVQSRPQVTDINEKVNDYLTKLVDYFISNEMKSNKTVPQELLHPPTQSAPFIDAPIDPELHTAFHWACSMGNLPIVEALYETGTNIRAANANGQTPLMRSAMFHNSYTRRSFPRIFELLSETVFDIDSMGQTVLHHIVKRKSSTPSAIYYVNVLLSKIKDISPKYRIELLLNTKDANGDTALHIAARNNDREFFDILIKNGSLSTISNNDGQTPTEIMNQHYQDLHLQAQTNIAGSNTSAYTDSFSSFGGKVKGSKLHSISELDDDKNTQNPENTVTNIVSNLHFSSNAAINLVKNIPAFTDSMKHLAEKFDGSYKNHEESCRSTEKMLGSIKRTVHSTDNRIREILETDADADISSAILAQEKDITELKIEAENHLRKLKNQFEYLQKQRLLKLTEYHNGEHNDTDNTLDNKIEICKQISVLQIERKRKISELISHYEDSRKIHKYRRMISEGTEMKTEEVDGCLDIILQTLINNSS
The following text describes a protein:
Function:
Inositol phosphate kinase with a broad substrate specificity.
Sequence:
MSDLHPPEHQVVGHRASASKLGPLIDGSGLFYKPLQAGDRGEHEVAFDEAFSAHAAVPARIRDTFFPRFHGTQLLPTEAQPEEPHPHLVLDDLLAGFEAPCVADIKIGAITWPPSSPEPYIAKCLAKDRGTTSVLLGFRVSGVRVVGPEGAVWRTERPEVKAMDTVGVRRVLRRYVSSVADEGMDCALAAAVYGGKGGVLSQLRELKAWFEEQTLFHFYLDLI
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
Subcellular Localization:
Nucleus.
Sequence:
MSNNGSQKRKDLEKFTVNDDFEGQPLKKKLKLGTESSIAMKLMSKMGYKEGRGLGKHEQGISQPIEASKQKGKRGLGLNSNKKGLQPSEVQWNFDAEELGKCEVIDWLTNPSFISEISPNWLENGPVKLALDNETKFCSEETLTSILEGKTIFDSVEPEDMMKARTRSNPYETIKSAFFLNRAAMKMANMDSAFNYMFTSPTNPDNKNESLIARDELLTFADICAGPGGFSEYILWRKKGMCKGFGFTLKGNNDFKLEDFSAGPPEMFEPHYGVKGADGDGDIFQMDNQKEFEEFVRWRTNGRGVHVVLADGGFSVDGQENIQEILSHRLYLCQFLVALSILRAGGNFVCKLFDLFTEFSVGLIFLMAHCFHRVNIFKPVTSRPANSERYLICEGLLQTDLTSDILDYFRLINSKMAASYLGDKSSNWMIRSIVPCRDLTSSETFFNYIVRSNNFLGEMQKISLHKIKIFVQNVNLHDHRQADVRRECLSKWDIPDETKTKNFDEQISAHKCYCSLVRNTYDLPTTALTSRNIDDIKCLRVVKTTVAASTQRCLLLAVERNQVFMRNKTTWERLEYVTSIPKNTLLDVEMVEEQRGDLSRLNRGGMKVKVIHVYDVITWFGNDVTGLNFEERHNLLRLLISASTKVTRPHVTPLHVKQYHNLADVGENIFNRLHYGLVKGGGQHAPKLLLPITDPEDNLPAPASSTFTNNRRDRYMIPHGIYLTVICPLPWIIGHSKSSKKDYYYHVHDRVSRYDMPDDARATYEVCLKNTFYWTWADEVKMLEKQEVKSKQTNNTLVTKEMFLEFVHKLSRL
The following text describes a protein:
Function:
Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity (By similarity). Affects plant morphogenesis. Required for the formation of wax layer that ensure cuticle permeability. Implicated in abscisic acid (ABA)-mediated stomatal closure. Involved in both biotic and abiotic stresses. Promotes salt resistance and defenses responses toward pathogenic bacteria (e.g. P.syringae) and against the fungal toxin fumonisin B1 (FB1).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MADGISSFWGPVTSTIECCEMNYAYSSYIAEFYNTISNVPGILLALIGLVNALRQRFEKRFSILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHYRSTMPTFLFLYGAAFAIVHAYLRFGIGFKVHYVILCLLCIPRMYKYYIHTEDTAAKRIAKWYVATILVGSICWFCDRVFCKTISQWPVNPQGHALWHVFMSFNSYCANTFLMFCRAQQRGWNPKVKYFLGVLPYVKIEKPKTQ
The following text describes a protein:
Function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Subcellular Localization:
Cytoplasm.
Domain:
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Sequence:
MNWTTDKVRQTWLDYFAKKDHLVLASKSLIPINDPSLLWINSGVATLKDYFSARKTPPSKRLVNAQICLRVNDIENVGFTSRHQTLFEMLGNFSIGDYFKTEAIDFAFDLLVNYYQLDPKRFYITVYEDDETTYKRWIKHKIDKNHIIKCDKSRNFWDLGLGPCGPCTEIYYDRGEKFDPKKIGEKLFFEDIENDRYVEIWNIVFSQFNNDGNGNYTELAQKNIDTGAGIERLVSVLQNSPTNFDTDIFLKLIKIIEAFCPFKYDPNSYFTFDPQKVKEQSYFRIIADHFKAITFTISEGVLPGPNERNYVVRRLLRRALIACKKLQLNLAFIEKIIDEIIASYENYYQHLKAKNETVKQVVLKEINAFNKTIDLGLVLFEKSVKNNTLTPQLTFQLNETYGFPVEIIRELVNQKGLTIDWTVFDQLMAKHRSISKQNNQTINFEKQNINLVNFKTKSTFFYHKNKINAKVIGLFDENYLPVKELNNQSGYVVFDQTVLYATSGGQRYDEGSCINHSNNNDQKISFQGVFKGPNKQHFHYFLVGSFKLNDQVTLSHDETWRKLAANNHSLEHLLHAALQKEIDPLIKQSGAFKSAQKATIDFNLNRHLTRNELEKVENKIRSLIKQKISSKEIFTDFEGSQKLNAIAYFEEEYSQHEILRVIRFGDYSVELCGGTHVANTASIEDCFITDFYSLGAGRWRIEIISSNETINNYLKAENQKLIQLKSELEKVLSLIDSSIFKVELKELQQRLDKFILPEKITQLRDASDTLLALKNDINQLKTKNYKVSQQALALSIKKQLLSLVDENKSYVIATFNDVEPKLLLQTLHDVFNQNQTKNFLIINQFNESNSFIVIGNKTTTIIEKLRNSFNLKGGGNDKLFRGSFQDNVTPQKLNELFQNK
The following text describes a protein:
Function:
Involved in astral microtubule organization by binding SCP72 to the outer plaque in a cell-cycle dependent manner. Required for the mitotic exit by facilitating the binding of TEMP1 to CDC15. Also involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation.
Miscellaneous:
MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus envelope. Note=Localizes to the meiotic outer plaque of the SPB, at the end of the meiotic spindles.
Sequence:
MDMDTQEAELSSQLENLTINSPRKLRSNAHSNSGKVFKEYESNHDFQDSNFTSQVVEPAISDSVKKPPTMTVLNNYSTVHQKVPSGFSGTTATSHQEAQWKQYFPGIGSGGGTNFGGAVGTANKVPESDLIVSDLVKDLSGVLETNTFKRHLDMKNKTTTMQTHENHDTISISHSKDFFNAEKVSSSFSDDSDSGPAAEAHDVFDGILQKQKSNYLVGSYPSNSNNKNNNNNNNNNNNNSININNKDNARTKEEDEEDTSNSFEFSSSSSMSSSQTQSGRKSKVLKKPPLNTISPGQLGYQFNHTHGAWDPPLNQGLDVSSSHSLDNTSSNQSQFATMVPTGDNHTNGKAPSILDKKAYELTSTKPGDVGYRQKKIQEEENLANSDDTPLDTPKFNDLFTKNGTRAKVKGQMRTSRSISNSNLLEAHKKLKTFPAERVEDITSISEVNTSFNETEKQLISILTSKLSGSPSYDSDWEKILKVDLSRGKLKNMFGMQRLLPNVLVLNLSDNEMNTLEGIPSNVVQLFCSNNKITSAHCSLAGFHDLECLDLSYNLLNTSLKFLSLCHHLQEVNLSYNSIQSLEGIGSSRMKKLNLSNNEINGIIDFEQLILTNNSVVGGWLTVEVLDLSNNNIIGVRNINCLPRLKVLNLNGNPLVSIVESSKMENGTLRALSIKNTGGALSKLQNYKLDDQFTFPYQNLKILKLDGFAQLSKWQKWPATLQILEINGGLASSLPRFSSLKSTNLYSLTIANVRDFTHLPVDLSKELPFLQELHLPGNNLQNAHKLTKTLPRQSVKFLDLRNNPITTPRHDRASTSLHYRQLLQLAGLCQQQCPALATLWLDDTPAPTATNL
The following text describes a protein:
Function:
Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Domain:
The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression, including both translational inhibition and mRNA degradation.
Sequence:
MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTISSSNNGKRASASGQQPAASRYLPREVPPRFRQQEQKQLLKRGQPLPTGTLTSVSPTQGAGPAGVSPPPLPGAGTQHHPSKLQPDLSHSGLADHYENSHWGQQPTYRSEANCSWDKVIIDRTDKEAWPSITGTETESASECTTDTDSASNCGSENSSMATGSAQGNFTGHTKKTNGNNGTNGALVQSPSNQSALGAGGANSNGSAARVWGVATGSSSGLAHCSVSGGDGKMDTMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVATGNPSSICSPVSAIGQNMGNQNGNPTGTLGAWGNLLPQESTEPQTSTSQNVSFSAQPQNLNTDGPNNTNPMNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVSGGSAEGISNSVWGLSPGNPATGNSNSGFSQGNGDTVNSALSAKQNGSSSAVQKEGSGGNAWDSGPPAGPGILAWGRGSGNNGVGNIHSGAWGHPSRSTSNGVNGEWGKPPNQHSNSDINGKGSTGWESPSVTSQNPTVQPGGEHMNSWAKAASSGTTASEGSSDGSGNHNEGSTGREGTGEGRRRDKGIIDQGHIQLPRNDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQASNSGGKNDGSIMNSTNTSSVSGWVNAPPAAVPANTGWGDSNNKAPSGPGVWGDSISSTAVSTAAAAKSGHAWSGAANQEDKSPTWGEPPKPKSQHWGDGQRSNPAWSAGGGDWADSSSVLGHLGDGKKNGSGWDADSNRSGSGWNDTTRSGNSGWGNSTNTKANPGTNWGETLKPGPQQNWASKPQDNNVSNWGGAASVKQTGTGWIGGPVPVKQKDSSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPVIQSSTTTNTTTTTTTTTSNTTHRVETPPPHQAGTQLNRSPLLGPVSSGWGEMPNVHSKTENSWGEPSSPSTLVDNGTAAWGKPPSSGSGWGDHPAEPPVAFGRAGAPVAASALCKPASKSMQEGWGSGGDEMNLSTSQWEDEEGDVWNNAASQESTSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDHNGMAAKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTPSPFLPSPSLKLPLSHSALPSQALGGIASGLGMQNLNSSRQIPSGNLGMFGNSGAAQARTMQQPPQPPVQPLNSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGSMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKQPPPPPPPPHLSLHPSAGKSAMDSFPSHPQTPGLPDLQTKEQQSSPNTFAPYPLAGLNPNMNVNSMDMTGGLSVKDPSQSQSRLPQWTHPNSMDNLPSAASPLEQNPSKHGAIPGGLSIGPPGKSSIDDSYGRYDLIQNSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVAGKLSDIKSTWSSGPTSHTQASLSHELWKVPRNSTAPTRPPPGLTNPKPSSTWGASPLGWTSSYSSGSAWSTDTSGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGNAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQSSSASSQPRLSAAGSSHGLVRSDAGHWNAPCLGGKGSSELLWGGVPQYSSSLWGPPSADDSRVIGSPTPLTTLLPGDLLSGESL
The following text describes a protein:
Function:
Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (By similarity). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity).
Subcellular Localization:
Nucleus. Note=Localized to the perinucleolar region.
Sequence:
MSKKPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPLERPSLRKEGLKDEEDLFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQVKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKAAAAAAAKNKTGSKPRTSANSNKEKERDGGKWFKVPSKKAETSTCIVTAEIEKKEELPTSSEPFGLHIDSVPKIVFPQPESTLTNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKEDCSATAPVLEQAISPKPQSQKKNEAVISSSANTQKPALLSSTLSSGKARSKKCKHESGESSGCIKAPKSPLAPELIQAKDLTLVSQLSSVINKTSSPQPVNPPRPCKHSERRRRSQRLATLPMPDDSLEKLSSSSSATDGKVFSISSQNQQESSVPEVPAIAYVPLQKLGPCLPLDLSCGSEVTGSQAPDSSYPGGECPREEKEETPLFANPTSKVVSDVKGAAAATGILKTEKKVKLEEKTSTAFGKRKEKDKERKEKRDKDHYKPKQKKKKKKKKKSKQHDYSDYEDSSLDFLERCSSPLTRSSGSSLAPRSTFTEKTTTYQYPRAILSVDLSGENLSDVEFLDDSSTESLLLSGDEYNQDFDSTNFEESQDEDDALNEIVRCICELDEENGFMIQCEECLCWQHSVCMGLLEDSIPEQYICYICRDPPGQRWNAKYRYDKEWLNNGRMYGLSFVKENYSHLNAKKIVSTHHLLADVYGITEVLHGLQLKIGILKNKHHPDLRLWAYSGKRKDQDQVVAGAERKVILQDTANSEGRKYVQNHKEPPLKMEETYITSEHSYQKPQSFSQDCHSLTDPGSSDDDDVSSFEEDGELHVADNSHLLYSVKERGVSEKNPASENKVFVYNDKKGMEGPGDAHLQWQLNLLTHIENVQNEVTSRMDLIEKEVDVLESWLDFTGELEPPDPLARLPQLKRHIKQLLLDMGKVQQIATLCSV
The following text describes a protein:
Function:
Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MAAGVWLLLSVTMFEAMSERGVHMEAPPLTPPIRNLSIDPAQRRLTWEWGGGGTRAEGGALGPRFLCRKEGRDPVRADPAGHSCSFPALSHCHVTNFTVFPEGQEKDAAHLCFQPRDPNRAAAARNLHCWVHDVDWLSCRWGRGPGATRDVRYRMFLRDARHSPDHDRECPRYEVDSQGSRVGCAVGEAGTLASLITVTVNGSGGAHGVHAPVSCTDADIDMAAVEVLAPPVLTAECESTGARVRWAPQSRFQTAFVFTLQINQSSQTEPKLEMVYETEFKVPTLDTVSVRVKATALDSGVESDWSKAWSLDCGPTATLATPMTSLLLAGAGAVLTVMAVLLLCWRKSLLSRLFPPIPRMRVLPGPEMVAWVEAPENCEVTLVTDN
The following text describes a protein:
Function:
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular Localization:
Cytoplasm.
Sequence:
MKDDIVAIATPLGFSAIGVIRLSGPNVINIVKRVFSPRRNKDLEKVSSHTLHYGNIIYKDEIIDEVLVAIYKAPNSYTGENMVEIFTHGSPIILEEILKILVEEGARIAERGEFTKRAFLNGKIDLLQAESINEIIRAESKTALKRALSKLKGEVSKSLRELKSKVEHLRIYLEASMDFPEDVEEREREDWLRRLEEIKREVSYLLEKAERGDWIKGGYRVILVGRPNVGKSSLFNALMKEDRAIVTPIPGTTRDYIEGELYLSSGHLVKIYDTAGLGIPKDILDKMGMEKTEKILEKSNLILFVVDGSGEISEEEINLFEKIRSYQNKEIILVINKVDLPQKVELSVFSEDIEKIFVSAKEGIGIEDLEKAIERHISSQELEDGIFLNVYHREKLKEIYQFCEEGISVLINLPQSLDILGDILYDMEKAFGEILGEEVSLDIADKIFANFCVGK
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-3 plays a role in development. G alpha-3 mutants fail to aggregate.
Sequence:
MDFNPVPPPRETLRAYLSKKGHVVKNWKLRLFVLKPGSSYMEYFVDETKEQQHLPQGRVPLYGTRVMEYVYNSNNNPREFCLSVETENKNWIISTGSKAQQLEWIEAIKHAIESAVETDEIKLQKHKSIEKQLQLDGKNKNKIPVLKLLLLGTGESGKSTVVKQMKILHHKGFSKEEEEFYRNLIYINLLDGMALLIHVIKENNIEIPQETLSAIKNYSSWYRVYIEKRNKNGIRNNPIGSMIPISILNNNKDNNNSNSSSLKNNSGGSSSSELDKKMTHLSLDGSTCINSNSASPNGPSSSTTTSTINTHNRSNSDGSSNNIFNVQDFGIPPIITNYISTIWSDPVVQSEVMLQAQKYHINESTQYYLNEIKRIGKPTYQPVNLDILKSRATTNGVVETDFNVNGEVIFRIVDVAGQRGERKKWINFFDDVTAIVFVAAINEYDQKLVEDNCTNRLHESLNLFDSICNDSTFPKTSIILFLNKIDLFREKLKRTSINICFPDYNGDQSYEKSSNYIKNNFLSKKKGGNGINSQNFIYFHFTCATDTKSFETVFNSVRDIIISKTLEFYC
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MTIQSAIDEARAACYKTRAIKSTYPNVPGKSLWGSCVDYFDRTAFTLNMVLNTHHDLQPTPLDVQTWLRAGLTYITVCHKGFELINMTNTMLPVITTSLTELIVNSLAISVIFPSCNTNGLVNVNFSDEYKLADLANEKPDVVVAQHGSGDFKSIQKAVDYAMIHRMPKKRFVIYVKAGIYKEYVEIPETVKYITMYGDGINKTIITGNRHCGGDMLKTSKVGDLQGSATFKVWSRKFITRGITFRNTAGPQGEQALAVLSSSDKSTFYRCSFEGYQDTLLTMAYTQFY
The following text describes a protein:
Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
Sequence:
MNSLFPKTLIPSTSLSSSTRLTLTPNSLRHFKLHLPRLMSSDSSHRLFQLKLDPLTGNSEWVVIEDNDDLPDCSKEPLLATTSYLDMLNDSFRNKAFRSGIERTVTKPCHVLDIGAGTGLLSMMAARAMGLNGTVTACESYLPMAKLMRKVLHRNSMGKAISLINKRSDELEVGVDIPSRADVLVSEILDSELLGEGLIPTLQHAHDKLLVENPLAVPFRAVTYGQLVESTYLWKLHDLSGIEAKVSDGIHLVPTGSDSIIHVKSRQYPMHCDAIREEIKPLSEPFKIFEFDFWKRPESNGETKVQVQVIDDGNIHAVVSWWVLQLDREGTVFYSTAPRWINSPANIGYRDWCDHWKQCVWFFRGKGMSVSQGEEVLLEATHTETIVSYNLNVQVPKTDTRQHDHNIRDFQLLLSPERIAIYGDSKWRSSVLAAVRNALQGRVNPLCVVVDDSIFLTLLAANLSKTSHVLSLFPGLREKGAQYLENVVKANSFSMDRVEVREKRKPCLTLHDTHGKKVDMLIGEPYYYANEGMLPWQNLRFWKDRTLLDPILSEDALIMPCKGILKACAMSLPDLWSSRCCLGDVEGFDHSIVNTTLGACGELPAPKEGPFLPFSIWQCGEIKELSEIFTILEFDFSKPISSCHGTAQVKFIEGGTCHGFVLWVDWIMDTDNSIVISTGPEHRYWKQGVKLLSKPVAVGINGCNSNSEYGSTIVEALFEPSSSELILKHAFL