lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Participates in the formation of new permeability pathways in Plasmodium-infected erythrocytes enabling the uptake of nutrients from the blood plasma. Required for maintaining invasion capacity of merozoites. Required for parasite growth and proliferation.
Subcellular Localization:
Host cell membrane; Single-pass membrane protein. Host cell membrane; Peripheral membrane protein. Parasitophorous vacuole membrane; Single-pass membrane protein. Host cytoplasm. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, rhoptry. Note=Export to host cytosol is mediated by the Plasmodium translocon of exported proteins (PTEX) complex.
Sequence:
MIKVTIFLLLSIFSFNLYGLELNEKVSIKYGAEQGVGSADSNTKLCSDILKYLYMDEYLSEGDKATFEKKCHNVIGNIRNTFSNKNTIKEGNEFLMSILHMKSLYGNNNNNNAGSESDVTLKSLYLSLKGSQNTEGESEVPSDDEINKTIMNFVKFNKYLLDNSNDIKKVHDFLVLTSQSNENLLPNKEKLFEQIVDQIKYFDEYFFASGGKIKVKKGYLKYNFLDIYKQPVCSAYLHLCSRYYESVSIYIRLKKVFNGIPAFLDKNCRKVKGEEFKKLMDMELKHNHIVERFDKYIISDDLYYVNMKVFDLKNVDKIQVSKIDDINNLNIYEHKETMHLSAKNLSRYIDIKKELNDEKAYKQLMSAIRKYVTTLTKADSDITYFVKQLDDEEIERFLIDLNFFLYNGFLRITEDKHLINADDVSPSYINLYRSNNIVALYILKTQYEENKLSEYRAHKFYRRKRVSNITNDMIKKDFTQTNALTNLPNLDNKKTTEYYLKEYENFVENFQPDLHDIMKLQLFFTMAFKDCNVNQNFTETSKKLWFDLLYAYDKFGWFYIHPNEVINSINKTDFVRHVLVSRNFLLKNNDQLTFLETQVAKIVEIINLSLEVDKSPDSLDFSIPMNFFNHKNGYHVMNDDKLKLLTSYEYIDSIANNYFFLSEYKNDVFRTGNNFKLYFNLPNIYSLAYQLFNELAININVITNVPLKKYLKYNASYAYFTLMNMIGKNHDIYSKGSRFVYASYILGLVFFIESHIDIARLKPKDFFFMKQSLPIIDHVYHKDLKTLKKNCTLLTDFMKINKNSQNYSLTHTEEMIKILGLLTVTLWAKEGKKSVYYDDDVSLYRKLMVSCVFNGGETIQEKLANNIEKSCDISQYGIKSKNLKDMIDINLSIHKWNPAEIEKLAYSFVLSCKMQKLMYKPMNVEKLPLEDYYKLSLAPDMVKTYHCYKLGKQAAELLESIILKKKFVRFRVTDAIDVYDFFYIKKVLSSRIKKEYNEFLQDKRAFEKKELETILNNSPFSEEQTMKLINSYECHWFTSYENFRILWMHASSNLGTGTYLKNFFSELWQNIRFLFKSKLKIRDMEYFSGDISQMNLLDYYSPMVHSESHCQEKMQVLFITLRDSKEENRSEIAQKVKSAYYQCKLDYYKNHHSDFIHRIHPNDFLNNKVYVLKQPYYLMSNVPLNNPKKVSRLFVTEGTLEYLLLDKINIPECFGPCTKLHFNKVVIKESKQRIYDMTINNALVPEIQPYNRRKYMTIYINEAYIKNIVSDALTSEEIKRHDIQKGNIKICMGKSTYLTEPILTEEHFNLTHKPVYDFSSVKHNLKVFHMKNEHLVSEDPNDDCFINYPLATINLDISDPYKEISEDLIKNLYILKSS
The following text describes a protein:
Function:
Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1. Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGKNELKGDSGQRFREWIKHVLNQDLVFQHIKIIYPTAPLRPYTPMNGGLSNVWFDRYKISNDCPEHLESIDSMCQVLANLIDEEVKNGIKKNRILVGGFSMGGCMALHLAFRKHRDLAGVFVLSSFLNKTSAVYQALKKNEDTLPELFQCHGTTDELVLHSWGEETNSILKSLGVNTTFHSFTNLFHELSKSELEKLKSWILEKLPREMEKKQVNKTSILSSNSM
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSYLGLPDNHRTTRRLSVAPRDHSDHAPSPVTRKIDELCRKVDYEWPELGRDNANILEVSLSLMDTSSIGKARFSKDYEKLTSDISNVLKDVVNDNYQGFNSSVGSYRSIAQSIAESHDNVRQLKQQLVESKSALSRNKPILKELGATSQRYKQMIQILEKIKDLKAVPDKLDTEISKKQFLSAQETLHSALRFLDDDGLASISSLEGLKTYLLAQESTIFAHLVEELHSHLYLKSPYCDRRWVGNISNLSSQSLTGARSVGDIEQVIMDKLDHEISKGGKATMTFSGSEELRDFLSDLAEHKDQPFEESTTSQMANPEQNSFIYIQLILETVNNLNRLPSLFEIVDQRLPIEIHKLVDKTVQEVAARFPKSLRDLQEYGGDNTEERGNSNNPSATGYLSDFFGPINGDIGLNVLKDLVWTLYSKLSACLEGHRAFYEVSKAITNRHDGHKKTLEYNFLGVWQTMESEVKMLLRSYITDASNISAPNRLDFDIPAPFRPMTKRSSSTRKPLFKLDNPGGIPDEFNQENDILRGVLEHSVPGLASASGNALHSTSRNAGSPFVTVDTALSHEMLTPPNVFNVRAFLDPTLLFMQKVQNIFPDPKVTGISHPRQFLDEFLSSVFLPQLEDSLENAFSATVESNEAFQITDGLSSKLAAPIFKSAEAFSTLVFQLCRLLNTSSLYREKYTSLILSLISKFVARYKIYFQTLISWADSDKDQSKIRLCARWAEEPKLRTISTEIVRNSLDTNQLIDEETTILLKLQGGLRKIQIPITKQDTLDPKSFRAMCTLVSSLEWSLEQLESLRNVVTETPPTSASGDSMAASGELRKRWTLTDASKLVSSSSESVSGLVKLTLAGQAVDEFDRTMKEYKSLSSQCLVTLRCDIRVRVMHYIEQAMINGDYYLDHPLDERDTFVSQLDADILQCDECMSGLLNPNFRHAVLKGVSKYIDNVFVASTQSLHALNANGVAKLLYNIHIIQQMLKSIMESPQQITFSSSLKYYELFDLDADTILAEVKEGKLKQFSTEDLRTLIKLKFNDVIHQHERLDRHEAVSSARTQLQSALTKLNETKFNDAKKQAVPSLPPRQEPSA
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MAPKSKEKPKTSASSQPPPAIEDLFTTLDRHIQRSEYEQAVKVADQVLSIAPADEDAIRCKVVALVKDDKIDDALSVIHSFHKLPIDLGFQKAYCLYRQNKLDEALECLRGRERDSETLLLEAQILYRLGKTDACVDVYRKLQNSEIETAEVNFVASLVSAGKASQVKGALESWKIKPTSSFELAFNTACSLIENNNYADAEQLLLAARRIGQETLTDDGFADEDIENELAPIAVQLAYVQQVLGQTQESTSSYADIIKRNLADESSLAVAVNNLIALKGSKDVSDGLRKLDRLKEKDSPNFQLSQTLDAKLSQKHKEAIYANRVLLLLHANKMDQARELCAALPGLFPESVNPALLQAAVLVRENKAAKAEELLGQFAEKFPEKSKSVLLARAQIAASASHPHVAAESLSKITDIQHFPATVATIVALKERAGDNDGAAATLDSAINWWSNSMTENNKLGILMPQAASFKLRHGQEEEASRLYEEIVKKHKSTDALVGLVTTLARVNVEKAETYEKQLKPLPGLKAVDVDNLEKTSGAKPMEGAAAAASAMQEEVKKEKAKKKRKRKPKYPKGFDPANPGPPPDPERWLPRRERSSYRPKRKDKRAAQIRGSQGAVTKQEKQEAAPSTSKSNQATTKSAAADPKTKPSSSKASKKKSRR
The following text describes a protein:
Function:
Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
Subcellular Localization:
Secreted.
Sequence:
QRGRNRQRTLSLLGPAGSAGPSPLATTXXXXPGLDDFLRQVERLLFLRENIQRLQGDQGEHSASQIFQSDWLSKRQHPGKREEKEEEGVEEEEEEEGGAVGPHKRQHPGRREDEASWSVDVTQYKRQHPGRRSPWLAYAVPKRQHPGRRLADPKSQRSWEEEEEEEEREEDLMPEKRQHPGKRALGGPCGPQGACGQAGLLLGLLDDLSRSQGAEEKRQHPGRRAAWVREPLEE
The following text describes a protein:
Function:
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKMLVEFRDFALKGNVLDLAVAVVIGAAFGKIVSSLVDNIIMPLVGVLLGGLDFTDLSFKVGKSVIQYGAFIQSIVDFIIIAFAIFIFVKVLTSFIKKKEQTVEETPVPPTEEYLKEIRDLLKEQQK
The following text describes a protein:
Function:
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Sequence:
MSRVAKNPVKLPAGVEIKLAGQQLSIKGAKGALELKVHPSVEVIQDSGELRFAARNGDQQTRAMAGTTRALVNNMVVGVSQGFERKLQLVGVGYKAQAKGQVLSLSLGFSHPVDYELPAGIVAETPSQTDILIKGIDKQLVGQVAAEIRDFRPPEPYKGKGVRYADEVVRRKEAKKK
The following text describes a protein:
Function:
MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.
Subcellular Localization:
Secreted.
Sequence:
MAKMNLSSYILILTFSLFSQGILLSASKSIRNLDDDMVFNTFRLGKGFQKEDTAEKSVIAPSLEQYKNDESSFMNEEENKVSKNTGSKHNFLNHGLPLNLAIKPYLALKGSVAFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV
The following text describes a protein:
Function:
Severs actin filaments and accelerates their polymerization and depolymerization.
Subcellular Localization:
Cytoplasm, perinuclear region.
Domain:
The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers; Regulated by autoinhibition due to intramolecular GBD-DAD binding; The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus.
Sequence:
MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MSNGIVAKRYAVALFKIAKEKHVLEMFEEELRLVQNVYVKNGELHSFLTQPNISKEQKKTFLANVFGSVSESILNTLYILIDNKRIDILPEIADEYVVLANEERNVADATVYSTRLLSEEEKLNIAEAFAKRTGKDAIRVKNVVDEDLLGGIKVRIGNRIYDGSLQGKLARIQRELMKNR
The following text describes a protein:
Function:
Has a crucial role in plant growth and development, possibly by influencing mitochondrial division.
Sequence:
MKALRVLRTLSSITTAQSPNPQKCFTSSSLFNRFYSAQPQHDDPLPPTTDEFHADAVFDSSHFDDLNLNSSNIDNGNQKPTWDDKYRDRVKSQVFQEDISQSRIWKREEEKKKKAGRLAESLLEAALDDDEYDDVEVGEVKDEDQKSLSVGIIGAPNAGKSALTNYMVGTKVSAVSRKVNTTTHEVLGVLTKGVTQMCFFDTPGLMLKKSGFPYSDIKVRNESAWTSVNLYDVLIVIFDIHRHLTRPDSRVVRLIERMGSISNTAQKRVLCMNKVDLVAKKNDLLKVVEEFRDLPGYERYFMVSGLKGAGVKDLTKYLMEQAVKRPWDEDPFAMSEEVMKNISLEIVREKLLDHVHQEIPYGIDHRLMSWKELRDGSLRIEQHFITHKISQRKILVGKNGSKIGRIGVEANEELRAIFKRNVHLILMVRVKS
The following text describes a protein:
Function:
Major protein component of the posterior mating plug. Accessory gland proteins constitute, or are required for formation of the anterior mating plug. Posterior mating plug forms before sperm transfer and the anterior mating plug is formed after the start of mating.
Subcellular Localization:
Secreted.
Sequence:
MVRQLILVLSLILFCGSSHAVVSELARQSESAIQGLADIKMAPLRYLDVLFGGNPGGLRGLDGGNSASLSTLQAAKVANILARGDIASSGYSKISAGVGKGSDLITIIKNTRSYDPYLIPPGIPGYNYPLGWPLRYPLGPYWPNRPPWLPINSPPIRPGGLFPGGPSPGGPSPGEPSPGEPSPGGPSPGGPSPGGPSPGGPSPGGPSPGGPSPGGPFPGGSPPSPGGPLGPWQFPWILGGPRPNRPGRPFPGGILPGHLDGSVVPNSVLNVAGGIFGNGGLFGTGIFGQHGLFGTGFLSGPSLDPFGIFTPIGNFFGSLGNLFGFSSPSQIIPIFGGKFGPLGRGLQGSITLDVGGTVPSVKGILGQLLHPFLGFLG
The following text describes a protein:
Function:
Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (By similarity). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-347 (By similarity). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity. Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (By similarity).
Subcellular Localization:
Mitochondrion matrix. Note=Detected in the cytosolic compartment of liver cells.
Sequence:
MSTAALLTLVRSGGNQVRRRVLLRARGLQDDRWVMPTCHSSTSEPKWSRFDPDGSGRPATWDNFGIWDNRLEEPILLPPSIKYGKPIPKVSLQNVGSASQIGKRKENEDRFGFAQLTNEVLYFAVYDGHGGPAAADFCHTHMEKCILDLLPKEENLETVLTLAFLEIDKTFARHAHLSADATLLTSGTTATVALLRDGIELVIASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMTRSLGDLDLKTSGVIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNTTAVVVPFGAWGKYKNSEITFSFSRSFASSGRWA
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MIMKFKQWIMVMGVICASFFQTLIPVESLPVAHKIKSLPGQPQVTFQQFAGFITIDEQQQRALFYYFVEAEGNPASRPLVLWLTGGPGCSSIGAGAFIEHGPFRPSGNNLVKNEYSWNKEANMLYLESPAGVGFSYSSNKSFYSYVDDEITAQDSLLFLKLWFAKFPEYQNRDFFITGESYGGHYVPQLAHLIVQSNVKFKLKGIAIGNPLLEFATDFNAPDEYNWSHGLISDAVYSLLSKYCNSSQIMREAINGIVSPACTAVYTQLSRELSQSIDRYYVIGDVCVQSSGQSQVETLYHPLKSRFETLSSFHSLSDASSQQAVRQSKEDVCAQENTAQYLNRKDVQQALHARLVGVPKWVLCSKVPNYDARDREIPTIPVVGSLVRSGIRALVYSGDQDSVIPFTGTRTLVHGLAMELGLNTTVPYRAWFEGKQVGGWTQVYGKMELSFASIRGASHTAPASQPERSLTLFKGFIAGKALPAT
The following text describes a protein:
Function:
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
Subcellular Localization:
Lysosome. Secreted.
Sequence:
MSLSRHRRVPAPARLGLALAFAMSQAWAAPPTAVTLDSGWQVRLVPGQEQAKTYPKAAAWLPAQVPGVVQTDLIAAKVVPDPFYRDNEGKIQWAGLSDWQYQTRFTVDAATLAREHVELVFDGLDTFAEVTLNGKPLLSADNMFRQWRVDAKALLKRGDNVLEVKLFSPIKKIQPWLAKQPYALPGAYDSAFGDEPESRHSSTYVRKAPYNFGWDWGPRMVNAGIWKDVRVEAWDAVRVDGLHIAQQRVDADSAQLQAQLELQAGRSGPVQVNLDVLGPNGQRVGQFTQDAVVDPGQNRIDLAVRIAKPKRWFPAGYGAQDRYTFVATVRDADGDSQQIKRITGLRSVELRREKDKFGKSMEIVINGIPIFAKGANLIPLDAFPSRVSQARMRSTLQDARDANMNMLRMWGGGHYQDDHFYEVADELGIMIWQDFMFGGAVPPYDVEFRENTRQEAIEQVKRLRDHPSVVLWCGNNEVQTGWENWGDRVKFKQSVDPEERSRIERGMTTLFGTVFREVVATYDSDVPYWSTSPGTNFDGAADQANDGDMHYWKVWGGPALPVTEYLNVTPRFMSEYGLQSFPDMRTVRAFAEPGDMDPESPVMRVHQKFDKGNGNKRLMLYIRREFGEPKDFESFVYLSQLMQAEGINLAASHLRASRPQSMGSLYWQLNDVWPGASWSSVDYYGRWKALHYHARRFYAPEMIAALRNDKGQTEVSLVSDRTTPLQARWRMRVMSMEGKVLSKREEKATLKPLSSLQVGNFSDKQLLGNADPKRSYAVFELLDGDTVLSREVVFFAAAKQLALPTATIDSQWRADGDGYALTLSSKTLAREVWLSFGDVDAALSDNAFDLLPGEPLTVHVTSKTALAQLQSALQVRDLASTLAGAPPEPAESK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSKRAAKSASSARAASTFGASTFGSSPATATFAVASSQLSYVSEPPDFSAISDPNVVVYFRNLSKKDSTTKAKALEDIQAYVAKESAVEEGLLEAWVASIDNAKAVRQNAHHLHGQIAAWAGKRIAKHMPQSVAAWLCGLYDSDRSVVEATQSSLRQVFNTPEKIQNIRKAYQQPILEYCRDAIDKESTATLSDERNVTPDDAEAKYSRVISACISLLGSLLSNLPREELSKYQTDYEALLGDKKLWEFASSKDASIRRSLHRFLKTCVAKEPEAVKANLETISKSYLSVALNSDQTNSAFEYIDALTALTSDHPTAWTEHYTSKTAVDRRLRQFLKKGSQSGPRDYWARLTALFHAIPSDVLPRNAADSAELLGALQGGMIKKDEPKHNYEVAFGTYLDVVALLNARLDNEDKKKLLDEMVLPLLTQYLQPSVETSQWSLPSSAISVLAKAARIDGMAAALAEQWPTYTKQLVDAIKTSAPEQSKDYEKSQVAVGRHATRLATLQEQALKHEAFAPVQTVFAHASANVVTEALSVIKSRNGKPYGAAEAIAAILKRNSAILASTETQQELELFLHFPEMWSSTLKTILQEPESSARTKALEAILTSPRIPASFDLASRDSELQTFVKSSVRESVESSGEWDSFSRILQSPAKIIASDTTDDILSYLTQSLTISQQAPYSLQVLRHIVRSNPSMLREFVGTPKGSKLLQGLLLASESPSDEIAQSALAVNASIQTMLASGSDSKQSMFELIQQGLREATPTSVSVETLVDLAKQCITAGQEWDVLKNVLPVVHDWEISLAPFLDSPPRPSLAITNPLGGAVYLVDQTASSTLPKVPRDADGYSAAYRITQYVTRLLQETDLFPPEKIPAELRDNYLRLVALTIQLADDNLGLAGANGLWVNYNAEAEADAMTFISDAQPFVTQELKYLSSEWSDNGLLPWATQLLSNVEATTSPRSYYTARAYSVLISDAIEMTGWRNAATPSLQDGLKAARKEKAIMPILAYLSAFKEPLAAAKACERMCNELIADLTGVDIAQKSDEALRQLVQLNSVLGQEGIIESIAKQRLVFFVKHVVPWVQSAEVGRPIRAELCRALTVLIPIMGDMYGEHWSDLLSSLSASWVSTNGLDNETGEDSSIPFVHASLKLYAQLRSLTQIEEPNDDLIDAWKETEQAVADGLINLLKHSQHFPDEFHQPLKMVNDVLSRQIAKVSLKNLESTEELFPLLYVESQPVQQTAFNILHKQIPEAQEQISVDAALEKTTARLPEELLSLIIDAPTVAALAEANFERNVPLPLRGYLLSWLLVFDHLEHASFKVKNDYVEHIKEGEYLPGLLNFTFDFLGHAHNKPVDVSKLNVTTYEPDVEPPKRDLQWLLTHLYFMCLRHVPSLTKAWFIDCKSRATVVTLEPWTEKFISPPVISAALDSVTTWSAQQDDTSPFTVRVAPRAREITASYLIDEATCSMRISLPPAFPLANARIDSLARVAVNETKWQSWLRTSLGAITIFNGSIIDALTTFKRNVDGAMKGQVECAICYSVVGSDKRLPEKKCGTCKNLFHGGCLWKWFKSSGSSSCPLCRNPFNYGEQRN
The following text describes a protein:
Function:
Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity).
Domain:
Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.
Sequence:
MPRSFLVKKHFNASKKPNYSELDTHTVIISPCLYEGYPVPVIPQPEVLRSGAYSPIAVWTTASPFHAPLPAGLSPLSGYPASLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLGKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCSHCSRAFADRSNLRAHLQTHSDVKKYQCKSCSKTFSRMSLLHKHEESGCCAAH
The following text describes a protein:
Function:
Methylation of the methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. It specifically targets the McpB chemoreceptor.
Sequence:
MPTSTPSPVFGNQEFHYTREDFQQVRERLYRLTGISLAESKAQLVYSRLSRRLRLLRLGSFAEYFTHLDREPGEQQLFVNALTTNLTAFFRERHHFPLLADLARRQLQRHRPLRIWSAAASTGEEPYSIAITLVEALGSFDPPVKIVASDIDTGVLDCARQGVYPLERLEQMPAPLKKRFFLRGTGPNAGKARVVEELRQLVEFRQINLLEADWSIAGELDAIFCRNVMIYFDKPTQTRLLERMVALLRPEGLFFAGHSENFVHASHLVRSVGQTVYSPA
The following text describes a protein:
Function:
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus. Note=Mainly located in the endoplasmic reticulum.
Sequence:
MRGSWPRLGFPALLLLLHLLTGSDAAVRNGTAKREIGDSRGSSGTCVKGFLQEILPLPATCPPEVLGMRGAVYILYDVNISEGFNLRRDVYIRMAVFVRRLQRRRRFRHVRLVLPPWPRLYHWHSQGLQQSGLPWSHFFDLASLRRYAPVLDYEEFLAEQRLFGNPGAPLVHVGHAFRLQHYEVMLEQGIFRDKFERVTDKPCSEGSLSGGPLLQQAELRVGRFHCVRFQGSAGLLEKLLREAIDEDTAGPEDVDDMRTYALLSAETVLHDHWGDEHFWQARRSMRFARRLEQVAADFRRQALDTTDASAGVQRPAMWELERPKRNAKGGDYLCAHLRRGDFVRSRDATTPTLKAAAQQVKQLLRGFNMTTVFLATDATPYELMELKELFYRFRLVHFAPESNVQRRELKDGGVAVVDQLVCAYARYFVGTYESTFTYRIYEEREILGFTQASTFNTFCKALGGSCSRNAVWPIVWADGDSDSEEDSDPY
The following text describes a protein:
Function:
Probable esterase; part of the gene cluster that mediates the biosynthesis of asperfuranone, a probable antitumor agent. The polyketide synthase afoG is responsible for producing the 3,5-dimethyloctadienone moiety from acetyl-CoA, three malonyl-CoA, and two S-adenosyl methionines (SAM). The 3,5-dimethyloctadienone moiety is then loaded onto the SAT domain of afoE and extended with four malonyl-CoA and one SAM, which leads to the formation of 2,4-dihydroxy-6-(5,7-dimethyl-2-oxo-trans-3-trans-5-nonadienyl)-3-methylbenzaldehyde (compound 2) after reductive release and aldol condensation. AfoD is the next enzyme in the biosynthesis sequence and hydroxylates the side chain at the benzylic position of compound 2. After benzylic hydroxylation, a furan ring is formed after five-member ring hemiacetal formation and water elimination. AfoF and afoC are proposed to oxidize the R-diketone proton and to reduce the unconjugated carbonyl group, respectively, to generate asperfuranone. Since no intermediates could be isolated from afoF and afoC deletants, the sequence of these two enzymes is not fully understood. Moreover, since afoC deletant still produces a small amount of asperfuranone, other endogenous oxidoreductases might catalyze the same reaction with much less efficiency.
Sequence:
MPALDIASAPAAVYQQQLHLPRILCLHGGGTNARIFTAQCRALRRQLTDSYRLVFADAPFLSSAGPDVTSVYGEWGPFRSWVPVPAGVDISAWAAAGAASRIDIDVEAIDECIAAAIAQDDRAGATGDWVGLLGFSQGARVAASLLYRQQKQQRMGLTSWSRGRDRKRGATSSTNYRFAVLFAGRGPLLDLGFGSGSLAGSSAASSSASASVSGSESAGEEEEDGHLLSIPTIHVHGLRDPGLEMHRDLVRSCRPSSVRIVEWEGAHRMPITTKDVGAVVAELRHLAISRKYESLRC
The following text describes a protein:
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Sequence:
MAERSGKIASGQVYIEVEYDYEYEAKDRKIVIRQGERYLLVKKTNDDWWQVRLDENSKAFYVPAQYVKEVTRKALMPPVKQTTGLPNNSMKTTQSMHLQRSTENVNKMPELSSFGKPSSSVQGTGLIRDANQNFGSNYNSGQTLNLSLDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLDIEKTSFSQEQSCDSAGEGSERTHQDSESGDELSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQVNGEWETHKDSSGRCYYYNRTTQERTWKPPRWARDVSTSRDFQSPGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGAAIEMASKDKSSKKNVFELKTRQGTELLIQSDNDAVINDWFKVLSSTINNQVAEADEAAEEEAPDSPGVEKQDKEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDVDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR
The following text describes a protein:
Function:
Positive regulator of brassinosteroid signaling.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Nucleus.
Sequence:
MDLSVLDRLKWLQQQQMVSPEFLQILGSDGREELKRVESYLGNNNDELQSFRHFPEFGPDYDTTDGCISRTSSFHMEPVKNNGHSRAITLQNKRKPEGKTEKREKKKIKAEDETEPSMKGKSNMSNTETSSEIQKPDYIHVRARRGEATDRHSLAERARREKISKKMKCLQDIVPGCNKVTGKAGMLDEIINYVQSLQQQVEFLSMKLSVINPELECHIDDLSAKQFQAYFTGPPEGDSKQSIMADFRSFPLHQQGSLDYSVINSDHTTSLGAKDHTSSSWETHSQCLYNSLRTDSVSNFFSLK