lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSENEVVGSPTTNGDKNEDGYPAENGEGTNVDDNNNEEEKDGIPLDNDNDENDSSEESATDEEAERQVREGFIVEDEEDEVPQEIRRKKKRKKHAESTADQDMLDEEDLELVMENTGQGSRFSKLRRLKRGRDQEETLENIFSEEEEEEENEVDDEAPNRTQGHRAGVIDEFADFIEQDEFEDEERQEEKYETGPPIESVRPEALGISDDDYIQIYEVFGDGTDYAFALEDEDAEDELEESVSLKTIFEPSELKDKMLTEEDEIIRITDEPERMQLYMKRNIDCSEDEFREQVAWIIDYLLKNRRDIDAELYEPFQTAVRYVVHFFIRDSLEVPFIWQHRRDYIVHNNRERNTITPLLSQNDLWNIFFLCTKFWSLHSKKQDILKLYSDLGINDDLVVPFCEAASSLDAIDDLNDYIHFTYSEQIRDRALLMGTGLRRPQGSKYSFFEKFRKSSLYNLVKEFGMSAKDFSFNVAQGARLRFVEDNTLSPEELSRTYVTNELSSPEQVLQKARRVLAEEIIHDPQFRKSFRDKLYNAGVVTVLATQKGVRKIGSEHPYYEFKYLKRKPLGSFELEPILFLKMLKAEEEGLIQLSIEFEDPDDVFKGLLELFVSDNFSENAMQWNAQRELVLKEVFKRFSALAPDAIRETLRSRYLDELGMRCRNQLFSRLDQAPYEPSTKNFDRGTIPSVLAVSNGKGESSDAIICVFVDDVGEPTDSLKLADLRDLANQAMFAEFVEKVKPDVIGVSGMSVSAHKIRQHVQDSLTSHEPVDLIMVNDEVARLYQNSTRAVDEFPTLPTISCYCVALARYVQNPLFEYAAMGRDLMSLSFDPWQHLLPPDVLWKYLETALVDISSLVGIDINEAVTNKYEANILPYIAGLGPRKADYVLKKIAATGGRIDNRSDLISKQIMSRKVFINCSSFFIIPNDEYPNMDILDSTRIHNEDYELARKMASDALELDEEDIEELETNRGVVYHLLEENETGKLDELVLEEYADQLEREFHQKKRNTLEKIRLELKDPYGEQRNVFHKLTPSEIFLMLTGENPEELQADAIVPVNVRRVTNRFVAVKLDCGIDGNIKADEVSDDFIPPPQLLQVGQTVEGVIISLDEANFMVDLSLRNSVLQSANSKRQTSSHRTSYWDTEAEKRDTERMQAETQAEQRVARVIKHPLFKDLNASQAEAYLSKMQVGDLVIRPSSKGSDHIVVTWKVAEGSYQHIDVLELEKENEFTIGQKLLVKGRFEKMTYQYSDLDELIVLHIKAIAKKIDEMCIHDKFRKGTQAETEKWLESYSEANPKRSCYAFCFDHQHPGYFILCFKASVNSPVTAWPVKVIPNAFFLQGNVYGDMTALCNGFKLLYAARTKNFRRM
The following text describes a protein:
Function:
Catalyzes the stereospecific oxidation of D-lactate to pyruvate.
Subcellular Localization:
Mitochondrion.
Sequence:
MRTLLSGWRALQSGTIGQRSSRTSRTNTSIITVSGAVSRGLRHQSNHHQGSSFGSNQHNGSVLQGRQRMAEQKWSTSMVFLTSTLIGSIMYVVGINVQLKQADGLASKTADEKFPSVPQPSPEDFRTALEKIQKILPVDCVSWHREDLLYHGTSPWTYHHPDCLPGAVLYPRSTEDVSKIAKIAYKYGIPIVPFSGGTSLEGHFNAPSSNPQSTVQNNQPDGDHTQLLQPGHSFTLDFSRNMDKIISIHESDLDVVVQPGISYENLNDQLKRTASSHKLFFPVDPGPGAQIGGMIGTGCSGTNAVKYGTMRENVINMTVVLANGEVIKTRQRAKKCAAGPDLGKLFIGSEGTLGLVTEVTLKLQPVLPTSVGVTHFKNVDAATKTVLELIKEGVSLACIELLDDQMMKAINHSSSGLNWDEKPSLFLKFTGTLEQIKSDEELTVKILKRSGGSKMRIAKTDAEAEEIWHARKVCLWSTLDYMPGHRAWTTDVCVPISHLPRLISETKTDIEARNLKATMLGHVGDGNFHCIILFKDEEELARVRECVHQMVELAQDLDGTCTGEHGVGIGKIVHLERELGKGTIGVLRNLKKTLDPKNILNPGKLIPPPP
The following text describes a protein:
Function:
Possesses E3 ubiquitin-protein ligase in vitro.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MELPWLDLPFTLLTLLLATRLAYDYYGVVAATFTGSFSLQIFLFYCFARWYRHTIAARAAADADGDGGGGAVADEEAAPPVLIPLLEGRGGGGGGAGAASSLANRCFAVVFMVFVPLVIVVFERSQADVVAYALCLANILVMVVWLSPDAAADPASAAKSFLRLSDDEDEGSCSGSGHGAAEDKCCVCLAGMREAQALRDLPRCGHRFHAKCIGKWLTAHPTCPVCRTTAVPPPAPLPASGDHADDAITPV
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEIKKDTSTENKETEEISYEGSAIEDKPRDVVENLQNELSQQKEKYLRLYAEFENYKRMIQKEREELVNYANEKLIKDLLPIIDNFELAIKHAGSDLNSDWLESMKKGVENTLKEFLRILEKYGVKQIETVGQVFNPEVHHAVSTVETEDIEDNIIVEELRKGYLYKNKLLREPLVAVSKKAKPSEEGGSSSHPSGVQNDRIEKED
The following text describes a protein:
Function:
Inhibitor of PPP1CA.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MADSGTAGGAALAAPAPGPGSGGPGPRVYFQSPPGAAGEGPGGADDEGPVRRQGKVTVKYDRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDELLDMESDDARAARVKVRGLGGDGLPEALPRETHPRRSEGPRPRRTVAPTGQSLPPNLVATAIPGNPAARPGAMSRAPRAPGPGVSSPAPSVFHFWGFLLLLN
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNITETAILICKIWGFTGLPQFKFENGKFEYKKSKSSIILIFIVILSIVFFIKSLHTTKDLLFYLTILQTGSLYLLVTGLGIHSYLKKRQIAIILNDLIMVTKMVCQFSRNNDLLRNSVSKPLFWYLIVQVAITGNKILGAVLTISPDAEVYLNVLFYNFAELFSYNINILIFFYLIIFQNAYTSYFKAITRKNTYNDPKIVVQIFYKFYEISNNINETLQVPILLRIFTDFVFTISSMFYLSVFLYIIPELSFFVLAKMVLWLVNTLFAIFIMAYFFDQMTEKRNTIMETLEDLPSSHTLISKFHSSYKRKELLRLRLKHERFCFNVCGFFPLNNSFIYLMIAGIVTYTTYLVQFGKAANAKQ
The following text describes a protein:
Function:
Plays a role in maintaining the mitochondrial genome. May have a dispensable role in early maturation of pre-rRNA (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MASPSSRLLKFITNGSKLHSAKNNNMIKNKNIISPTITKLFSTSKISNEIGNIRNFNNKISTNLINSNINTKPFFEIPKLFEKKYYSYIPPTWEEKDKEKQFNSITSTREEGGDNEESNRMGNGSIKDAIVWVNHLYPIKVSRLDFRSLFFHIPITKKLNSLFPNDVKIISIEKRIKEGGAYIHFQYDSSNPEYKSIEMVMSKLKSIFAQEKKHFHFASRPAKCKLVYGRPFVEDIDYRFPSTTLKITFKGSEMSPDDLFRLMRPYGHIKDIHYSSPIPSKDGPRQATITFKRMEGAIATRNCLHNKYFPEFNTSLYMDYEQLMRINKLKEQFSKHPKIMIPLLGILATLLTLLLFNPLREYFINKKLSSPCYFGEQEEDDWQERSEQKVLQTHFNFPPNSIVMISAPKGSGKSSLIDKVLENRINTLLIDCNQEVNNNDEEFIESFSKDIGFSPSYSLYSSFGSVIDAIIPTGKGAFHSTTNYQMQTILKLLDEVLAKKAKQFPVDPHQPYEYPLIVIDGFFGMIQAMESKEKANIIMDSVIQWAITSTQRGHAHVVFLSSDSFAGDIIKKYLDNRGGGQISTIQLGDVQPSMAINYIKKRIGPNTPITQHDMELVVDNLGGRYYDLNVLSQRMIAGDSVERALSNMISKAVSEIRAEGFGLSKRNDDSKIGGTKLKWSRPQLWETIKKIAENDFVSYDDLLFNVFLGDESSLNNLISSNLLRFQNVDNERKVTAYSPLYCSAFKQMVNDLEFNVGMDVLVQKARIEEELSKLSKVEDELLKIKNLTSKSWFEPLSIKKRRILLEDKLKDHVAKIEHRENILKKHSLFQKFLREEQMIQMELIKKQREQSKFERQQQQLLQQQQLQQQQQQQQQGSI
The following text describes a protein:
Function:
Assists in the loading of diacylglycerol, generated from triacylglycerol stores in the fat body through the action of adipokinetic hormone, into lipophorin, the hemolymph lipoprotein. It increases the lipid carrying capacity of lipophorin by covering the expanding hydrophobic surface resulting from diacylglycerol uptake. It thus plays a critical role in the transport of lipids during flight in several species of insects. Has antibacterial activity against the Gram-positive bacteria L.monocytogenes (MIC=6.5 uM). Lacks antibacterial activity against the Gram-positive bacteria B.circulans, M.luteus, S.aureus, and S.lutea, and the Gram-negative bacteria E.coli D31, E.coli ATCC 25922, and S.typhimurium. Lacks antifungal activity against S.cerevisiae, P.pastoris, Z.marxianus, C.albicans, C.wickerhamii, A.niger, F.oxysporum, and T.harizianum.
Subcellular Localization:
Secreted. Note=Secreted into hemolymph.
Sequence:
MAAKYVFVVAACSALAQAGIVRRDASTPLQDLEKHAAEFQKTFSEQLNAFTNSKDTKEFNTALKEGSDSVLQQLNALASSLQKALNDANGKAKEALEQTRTNLERTAEELRRAHPDVERQAGALRDRLQTAVQATVQETQKLAKTVGANLEETNKKLAPQIKSAYDDFVKQAQEVQKKLHEAASKQ
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGKKRRFIMAKMDVQKIIAPMMKFVNMRGIIALKDGMLAILPLTVVGSLFLIMGQLPFEGLNKSIASVFGANWTEPFMQVYSGTFAIMGLISCFSIAYSYAKNSGVEALPAGVLSVSAFFILLRSSYIPKQGEAIGDAISKVWFGGQGIIGAIIIGLVVGSIYTFFIKRKIVIKMPEQVPQAIAKQFEAMIPAFVIFLLSMIVYILAKSLTNGGTFIEMIYSAIQVPLQGLTGSLYGAIGIAFFISFLWWFGVHGQSVVNGVVTALLLSNLDANKAMLASGNLSLENGAHIVTQQFLDSFLILSGSGITFGLVVAMLFAAKSKQYQALGKVAAFPAIFNVNEPVVFGFPIVMNPVMFVPFILVPVLAAVIVYGAIATGFMQPFSGVTLPWSTPAILSGFLVGGWQGVVTQLLVLVISTVVYFPFFKIQDRLAYQNEIKQS
The following text describes a protein:
Function:
May be involved in cell wall biosynthesis.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MEARRQAVSRASCSFYTTLTTLFVLLWIVAYGARYGVPSVRNLKSTIASYNIYTPLGSSPSHVVPAALNSVDDLIAAIQKAAAAAAGGRALAEEAAALGKRERAEWHNNNPCRSRSELQGMYDRRKFARDVSPNSRWETVMDEYAKLHRTCLRLVRNSTEYFLNRSSSTGCKFVILDTPKVGLGNKLLLKASVLLFAVLTQRVLLIPSDNQNGLEQLCEPFVGSSWKLEKDSAIQNYAHLWQSTGAFQKWVDRNEIRSERSPRTPDQFFAANLIDPYQPMVRFYCNTEQAYLSKVTWISIGGCVYFLPKLFAIPAFRPALEQLFPDRMVLTHIMRSMLLPADHVWERIRNVEDVYLDTSHKRVGVQLRFFGLQSQYKHKNDIVNEHVLQCGNENGFLPRVLPPRVSSSRYPQNAEKPRNITKVLIASLFPGLHDYLSPIYLQQMTETGEGVGVVQLTSENEQHFGSEVDVQAFVEIMCLSFSDFLVVTPWSTFGGVAQAYGALKPWFVNYDSDGPACDRAQTVDVCFDQARDDFLCPHDPELHGKSLLSHVPYIKRCLRNDADGVQLITDHESNAPLIPTK
The following text describes a protein:
Function:
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Does not have cyclase activity (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPPIAQEGNCLIYRGSNFLKQRLILACLSGKPVKISQIRSEDETAPGLREYEISLIRLLDKITNGTKIELNPAGTSVMFSPGLLHGGQLNHDCCVQRGIGYYLDALIALGPFCKSPLQCTLRGVTNSKDSPSVDHIKGAALSLLKRFLLVDEGLELKVVRRGVAPLGGGEIIFRCPVRKSLRAIQFQSQGMVKRIRGTVYACKVSPAMANRTVEAAKGCMLKFLPDVYIYTDQNKGKMSGNSPGFGICLIAETTDGVCFAADCCSNTREESEDTPSIPENLGKEVALRLLDEIYRGGCVDSSYQWLAALYIALGQKHVSKFLTGALSNYTVHFLQHLRDFFSITFKLENPEAEDEDEAENVRGAQKVLMACVGIGYTNINKRVI
The following text describes a protein:
Function:
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Subcellular Localization:
Cytoplasm.
Sequence:
MPKHRKQSKIKIYRITSYKKDKRSELDSDKFELEQQDKHDIQDKQDKQDEQNKQDKQVQSENVTIVPTDSHSLDVWDEISLKEIQAGEHTSLFEEKSNYQNINLVQVNDVRLYLDKQLQFSSVDEQIYHEALVHPIMAKVIDPKRVLILGGGDGLALREVLKYETVLHVDLVDLDEAMINMARNVPEIVSLNKNAFFDNRVNVHVCDAKEFLNSPSSLYDVIIIDFPDPATELLSTLYTSELFARIATFLTEDGAFVCQSNSPADAPLVYWSIGNTIEHAGLTVKSYHTIVPSFGTDWGFHLATNSAHVLDQIEQLYVVPTPRTLPALLFPLFQFKEEHLEQRNLALLNSESNLILHQCYKQEMKF
The following text describes a protein:
Function:
Binds DNA; this binding is disrupted by nitrosylation upon exposure to nitric oxide (NO) and also by EDTA and iron chelators. The 2Fe-2S cluster is stable in the presence of O(2).
Sequence:
MRLTKFTDLALRSLMRLAVVRDGDEPLATREVAEVVGVPYTHAAKAITRLQHLGVVEARRGRGGGLTLTDLGRRVSVGWLVRELEGEAEVVDCEGDNPCPLRGACRLRRALRDAQEAFYAALDPLTVTDLVAAPTGPVLLGLTDRPSG
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
STVYESYDHTFVACPEHLRFRFLYTFLKKNLDKKIMIFFSTTNSAKFYARLLKHFHITVLTMHGKQKREQFINTFFKFSDLEEGILCATDAAGKDLDIPPSVDWVIQFEPPDDPSEYILRVARISCDSDRVGRSLLFLNPGEQGFLKYYHAAAIPVSEFEIPKLADIQAHIEYHVNENERLLNYARDAYGSYLIAYASHSYRDVYNVHDLNKDDVAASFGLVSLPAIDDDSDEDVSDASDDVTRVRASSRERKERNKKKGWKSEKKEKKKTWMKSEKSWPHCQIKVHPKFRDGYVPREEFKE
The following text describes a protein:
Function:
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Subcellular Localization:
Nucleus.
Domain:
The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.
Sequence:
MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPPLLSRPLPLGSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKSAH
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Cytoplasm.
Sequence:
MEPCEDKCKRGLSLNFFEEDGPSLRLNSDSLDFLARDFKVEGMSQDNFDQKTKLYITEESLQKEVNIFLTKIYIRESEREPPQSHNSVFQLLSKIRNSVPNVSAFRNNLSILSKELSFFSFARHIHNRRLCWAEFIYCIRRGIKAIFKTTVQFLPTRLAKIFEKKASEVLKDNLLQTCNSKREGEVCDVKEPAVASSESSDCFNDMQELNNIVDLRDYSNSRFQQNRLLDRNLKGWIQGESEKALKGRRTTKRNDKENYNYPDFSNDNELLFSLATLIVENNPKKENIIPKYYLRYLQRLSRTEINKEIIEIEKLELEVVQFQMSIANLINTQVEVTNTIEELGLRCRPLPNENE
The following text describes a protein:
Function:
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTVDMSTAKEVKLLTLLNVSAVKRPRELDLPGGHRSSPSLKGTSTQQNSEDGESKKRRKSVVWGGEVGPSGSHYLKGSGKREKGKAKEKTVEMNENSANGDAAEIVEDDDEQSDKEEEAITSDLFNIHFSAAPPILTSEALSSAEGNQWKSERKSLKGFGRVVELTPEKSAFGFVENQKTRITPSLLPAIKDSSATIPLLSTYLSHLGTYKDYYLHSLDGEADGSETQLIGQHKEAMRKAAVIHSVNHVLKTRRRIIRNNEKLAHAASSDNSTSVAEPPRDQSFIRPKVLFLLPTRSLALSYIKTHLFPLAPAGTQIENQRSFVSSFSLPQDEEDPLANPSTSADFPIDHLVNFRGNSDDNFRFGIKITRKAWRVVMMPANEEKLIDCDILISSPLGFKMAAEREDSTDLLSSLEICIVDGVDVMQMQNWEHVQFIFNNINQIPKSPHGCDFSRVKPWYLESQAKYLRQTIIFGRYDTVEARALFNRSCHNLQGKVRSERNDFGGVMDRVRPGVRQVFERFDLEGPKGMNGEAAVDEVEKRLKFFTENTIPALLRAAISRQNTLIVIPSYFDFVRVTNYLRKADKVSFAAISEYSSNAEISRARTLFFKGKKAFLIVTERFHFYRRYKIRGAKTIVFYSLPDHAQFYSEFMDTPFLASKNKSEDEVDIDEAEVSSRVLYSRFDALKLERVVGSENARKLLKTSESRFEFI
The following text describes a protein:
Function:
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTGAAKEQSLPSVMGSIPEGILEDIKVRTCFVSDLKRGLNIQAAKFNIDGNTERPSPPPNVDYPLDGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLATKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKDYYNQTGRIPDWCSLNNPPLEMMFDVGKNQPPLMKRAFSTEK
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MRFSRRPRVSSVLTAYFMWSWSALLASAAWWLLTVPPMTERYENTSARGAKVYCDSLRYLKPYQYQRCLRQPTLMAVISDGIKSGIRECQYQFRNSKWNCSTYPGPPGRHAFHPILKARGREKAFVYAILSAAVSYEITRACSNGAMLSECGCAKINPHDRKRGGNFVWGGCSDDVKIGDEISRSFLDGDIVTAKSMKKQLRKHNSEAGRMVVTSNMRKVCKCHGITGSCAQTVCWRSMPTLRFISHRI
The following text describes a protein:
Function:
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MKLFKPPWITHDDKPIFSIDIHPDESRFATGGQGDGGSSGKVIIWNMTPVVNQKDEVNDKIPKVLCVMDNHLACVNSVRWSCNGRYLASGGDDRLIMIWQFAGYGGAGVFGGQPTLKTSTGERWRCTHTLKGHTGDVLDLAWSPGNQWLASCSIDNSVVIWDVEKFPAITTVLKGHTSLVKGVTWDPIGSYVASQSDDKTVKVWKTLDWKLETTITKPFDECTATTHVLRLSWSPDGGILVSAHAMNNSGPTAQIIDRDGWKTDMDFVGHRKAITCTRFNSCMFSKLKTEGESKPYTCCAVGSRDRSLSVWLTSLQRPLVVVHDLFDNSVMDISWSFSGYSLLCCSWDGTVAYIQFTPQELGQTLTQEEKNKLHKETYGKTSTMVSQPLIIENPAMLAIQEKKNDSSVNDQNEKLKPPTTPIKYPCRFVLLNNRNICDWTKQIETRTPSGKRRIIPVFVAPQEALGLSFQTPFFMHQVDKSKTSPHQNSSDKNPTTLKKNENESNIQPNAVQSSVTGKEKTQESFSSPAKLDNDTAHQVYIIRLCEKTLPSVVKEKLVPRSVHFNEQLEPANYFDIEFSENSPSPFFPPSITFHHQTNRLPSSCLPTETWETSSASEEEAGITARITWEEETQNWKRIWRTSEQDMMNMKRKYFHKICIQPVYKSFCNINIFYPPLSVFAFIFKLNININHLSILCYCSGSPSTHQNNSNTSTHDHHQCITSFKIICCVDKDEVWTSVMSAPATAVSLSRLIVCIGCSDHTVCVLSTKSGRQMLPQICFASSSSPLALLQCRGHFVMAVDALCNLSIWNTQNGSVVIDNKSFLNQIISNQNKPTSNSSEAMLQKCSLTDRGLPLITLSNNKALTYDVSLAAWIFVSLPGDSIEQFTDHITVTHDHSHDEDDINGLLSKKFSSGMGCQAGRTFHATASAQRDATLVSLERKLSASLLLQSASHYKRWLLAYVRYLVQGNYDLRLREVCDDLIGPPADRTISDNHVSWKPYILGLSKRMLLREEVLPVIGANLSFQRMYTEYHDQLELA
The following text describes a protein:
Function:
Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSSGTSGDQISHFGKTLTTTASLVFGSQSMEDTILSYSSPYKKILHDTITSSGGTSSLMKVERSGRMFTPFRTRNSAFQDIFHASSGRGYFKNGFSDTRTSFQVLSYLSDAMLADIPSSESAAATSGKLVTEKGEKGKKKRAETAHARGPSLYQGFEASLPTINQTITTHQKKQIMNRDIKSIRESDATPEDVGQDVDIEKGEEETTHDEFTLPKGIKPEHLSNSYSIKNLKGAVQTITDNLDLLEIQKNLAASEIRELDLKMEKLKLMRDLVFRRVAKIEQNELFLEKHLMNIRERIDMIEEYNLDNDTDAEKAYEEATSAPEDTKDQYSELPDANTAESGETVVQEPQVNLASAQKSLKKRSKQTGYSHKNHEKKVQQHEFRHLRKTYPTLQQYYEPGANILSFDSAHEDNVTCLDFNLPFGTLCSAGKLDPTIKVWNLSKNKHVASITGHLATVSCMQMDQYNTLITGGRDALLKMWDIQKAIDNDSIPSDEVCIYTFDSHIDEITALSFEANNLVSGSQDRTIRQWDLNNGKCVQTLDINFATGGNLSRSMIGSGFLNTNNDHPIIGAIQCYDAALATGTKDGIVRLWDLRSGRVVRTLEGHSDAVTSLQFDSLNLVTGSLDNSIRIWDLRTGTLADTFSYEHPVTCLQFDLNKIVVANQEGTVKVYNRQEKKHWFCGGDEHSENAVEYVRYKDGYLVEGRANGDINAWAI
The following text describes a protein:
Function:
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
Subcellular Localization:
Nucleus.
Sequence:
MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQSHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAGLQGQVSSLSHLNSSGSDYGAMSCSTLLYGRTW
The following text describes a protein:
Function:
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MLPNTPRRAVYAGSFDPPTLGHLWMIRQAQSMFDELIVAIGINPDKRSTYTVAERQDMLCDITKMFPNVRTDVFENRFLVHYAREVDAGFIVRGIRSASDYEYERSMRHINSDLAPEISTVFLMPPREIAEVSSTMVKGLVGPEGWTETIHRYVPQAVYEKILAEHQHEN
The following text describes a protein:
Function:
Guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP. Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis. Binds the Rab GTPase YPT32, but does not have exchange activity on YPT32.
Miscellaneous:
MISCELLANEOUS: Present with 13200 molecules/cell in log phase SD medium.
Subcellular Localization:
Bud neck. Bud tip. Cytoplasmic vesicle, secretory vesicle. Note=Localizes to sites of polarized growth, namely to the bud neck and to the bud tip of growing buds, and associates with membranes. Colocalizes with secretory vesicles at exocytic sites. Proper localization is dependent on the actin cytoskeleton, MYO2, the kinesin-related protein SMY1, the Rab GTPase YPT32, and the production of post-Golgi vesicles.
Domain:
The N-terminal domain (1-374) is sufficient for the exchange factor activity.
Sequence:
MDASEEAKRVSIQVTSLSTQLIESVDKQSHLEEQLNKSLKTIASQKAAIENYNQLKEDYNTLKRELSDRDDEVKRLREDIAKENELRTKAEEEADKLNKEVEDLTASLFDEANNMVADARKEKYAIEILNKRLTEQLREKDTLLDTLTLQLKNLKKVMHSLDNESTVTNNSNRYSTILSDSATSSSTSLNKVPTSYSLASQDIYSGIVYSPSISSIRYDISLYNEFLKFVAALPRCENIKATSTESKLIRRLVNDEIQPILKIDNASGIGWLVKKTLLSLIIDGLVVVEPLSGVNATYQIGYNSSSPAKQATSNMPKMFKFPLDSPPVAVHAACSFCGESRDDIIEHARMYILKTLHKTDDGKEQVTNTYPLCHWCLLKLRQTCEIFAFLRSLKVGAWHLEKLTTQNITKEDLEKFSEVTKHTKRDGRVSSQDKKTKRLSFMAGLGINSSTKNKPKMEIFSSETNAKPGQPTTNIQRAWLQLCKLRCILHWTHIGIWAVDDSISSKIGPLVEDDSDEDQNDAISVRLQDKALWKQDAKRPFSSSSAEESQKSDAFDFESGDMENEITGESSSDESSSDGSSTDNSTADSSSEDESSLADSTTSSADSSSPESIDNGEGDDTVTKDDKSSIKSANNNEENSDCGDKKGRSIIKKKAPQRKIQKKKLLQDLDDLEEQFREESAIDQTEFENAESNVKQNISSKRASSGDENSKKDNNEKTLKTNLTIGDKTQEQIGENSPSSGLHASSSNDDNFDDAQEQQ
The following text describes a protein:
Function:
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Domain:
The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.
Sequence:
MMMDCDNVLDERIDPYELERLRDQYETQVRRGQPSHLAKFSFAHGLIKSTKNDVHQGIAILEQLLRENGQDISMRDYIYYLAVGHARIKDYDRALAYIETLLHAESTNRQAMNLKELIEKKMRNDGLLGAAILGGGAAIAVGSLLALIFAGRK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEDFNNDDPMNFDKDDMINNNNDNNNNNNDNDNNNENNEDSNNNSNLENMISDTSTPRILEEEPDLTQVMWRDPLWLQMYPLNPQTILQYFSYSQFYDKNCNNEQLKMQRLDLSALKNMDGLEYELIKFVEPSFFLIAKQTRISPTDVLINTLYYVINGNIYQAPELHVVFKSRVSQSISHLSEAFNSISSIVNWDIVNGYSLNLDPSNQQEKSKLAAYSRKQIEDTKRLDQLINSLFIKFPAINRPVENPQQMGGGITPQQQPSQP
The following text describes a protein:
Function:
Transcription factor that acts as a transcriptional activator (By similarity). May function as a switch in neuronal development.
Subcellular Localization:
Nucleus.
Sequence:
MVQQAESAESESNLPREAMDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKMDPSAKPNAGQSPEKNAPGGGSKSAKSSGKKCSKLKAAAASPPKPGAKAAPHGDYAGDEYVFGALKVSSKAVKCVFVDEEEEDEEDEDELQLRIKQEADDEEEDEEPGPQQLRRYNVAKVPASPTLSSSAESTEGASLYEEVRGAAGGGRLYYSFKNITKQGPPPPQPPAGLSPASVPLHLHLVGRQRGGGRPPVRPQPQLLAAWPRRRRAGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPELSEMIAGDWLEANFSDLVFTY
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MDLSHRLPYPDPDVYLNIFSDGNIKSCYRDLYAKYGKKITIAMGKITKEIQNLDETEVFACFNAARICIFNNSPKIRRDALFLIAEISKTYLTEHTLPYFLILAHDDNAQIKQDASKALAAISRKIGGLKKAKEIVISALGSMGATAFNRENLIDPEEILGKSRIAGSVCLSSSQILGVMMDDLKQNEKAELLQYIRKATEGLYDTLNDIQNSSNDTLFYSPRLRSALYKLHYEALPIPKCPHPLVEKLLLEIDPQCMKVAAQLIPKLCKEDQWKLFIQNPLYLNEFYKEFLANCDDSTINISLSRNLSQENMTNAINLLIKNNFQNIDVVAICNNPYVWSILPEKLIRDVIKCANTINPKNVILYSKYFDNIQQIRFPDKSLPEEMAAALISVAKTTDINYIEQQWPNATNNCIRIWNKSPKTDWWSDILKENLRYYIEDDCGAISMAVPVSESSNFANLVAEVVIDRLNKGQEVTDDMWYATAITDPLIDVIIKLNPNIQIEATKKQDIYTAIYQNIIINTDESEAGELIGHISLSSQTSLMEFPNSYDFLSHFFKVVSIADVPEDIELQYLKDYFEISYSDFLLHVFLGKFDASILDSSISKFVYSIPFERRQNLLSQSIRNQFIENSVILLISADENDRNKLKIDECDILAPYLSMMNIDYDWKSDFAKFCRGEKIDISNFKGSMEELLWIATKENCPQYISNICASIFPVSLSINFHLFISALLNTDIETTKFRELLDTALQSLDNLTPLDPQTVLILSDCFAKMSLLQADELISFCSSVSSLLASQHVPSIVSCLHHSIPFFLQKVTREKWIELRNSLSQGPVSGLIEFDSIISEMFSEDDLSMFRDFPSAASRFYANFNKKDELKDLLSGLSHQMIEDELKKAQNYTIENILISVDVNSHTIHAESISTDDPFTLDVIIPDIYPLETPLFRVSSIGKEKLTQDARDEVKKECMRQDGIFAAISTWAARIDSVISKVEVCPICLSLLDAGMNLPKMKCSTCHKCCHASCLEKWLRNSLKKNCPFCRTKWHRQK