lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Sequence:
MADVDPDTLLEWLQMGVGQERDMQLIALEQLCMLLLMSDNVDRCFEMCPPRSFLPALCKIFLDETAPDNVVEVAARAMTYYLDVSADCTRRIVAVDGAVKAICNRLSLRLSDDRTNKDLSEQCVKVLEFICTREPGAVFEAGGLSAVMKFVCNCGSIIHKDTLHSSMFVVSRLCGKVEATSDSLPECIQSLSSLLHYDDAHVADSALKCFSSLADRFARKGVNPEPLDAFGLTDELIKRLGNCGNRVPGTPFSKTKQTGGTPNATPDSKANFGITTVVNLLCTLCRGSSEITHKVLRSDLSQAIEDALKGNERCCLDTMRICDLLLILLFEGRQAIPKHYLGLFGAPRCLNLSNRRMETMDGERSHRQLIDCIRSKDTEALIDAVESGVYDVNFMDDVGQTLLNWAAAFGTQEMVDFLCDRGADVNKGQRSSSLHYAACFGRPAVVKTLLLNSANPTLHDEEGKTALEKAKERNDDGHKEVVKLLEDPGILQCVKFQEQTKDAEKKSKEEEKQNLIKGDSPVASVFINKLLPLFLDTYQVTVYPSVAQSALSLLHKTVKYVVEQQLRDAVLSAQNIPEKFANVVSTALDQEDNDEGHLAALEIIQNLMDKCYDLFACSLNHEWIANKIRDMFAPHEDKEDDGAVGGQAEGIYLFLYINIPVAQESSNKLEECMPTSVEDATSMKPGSLYSWKKTWTFARGKGCLYLWSSATAIELSHGSNGWFRYILDGKLSTMYSSGSPEGGTDSSESRSEFLEKLQRAFMEASTGEVMLPVLSKPDSVRITAGNWTIVSNKEDELLITNSDGQQATILKKEMSGFLFESNRGTRHAFTPESLLSMDFLNKSVDKKTTQPSMNKEEELKDKIVVLSRSLYDEYFTSKKQAFKNVVTDLKKIAQKIEEFSSRDSDINRKCIFYVVTRIVQQSSLTQLRTLLEEDKGVSAFDLYNSGLIQAMLKALLTNLNACPIVCFKGTCSGRDDRIEKFKLVFSKATSDAVQVLVRKLISVLESIERFPVQLYDSPTSFNRGLHLLSRKFSFKMEYQCCADDSNLVDYTGRTLKMETLSSVDDLEQHILKMASKQWYDHDVSNHAYVMRAREGEVNFKYSSDFDENGIIYWIGTNAKNEYDWTNPASYGLVHVTSSDEGGLPYGKLEDILSRDTTPCNCHTSDNEKAWIALDFGLQIIPTKYSLRHSRGYSRSALRNWLFQASNDGKNWTTLVTHTNDKSLNQPGSTASWSIPVDEDEKRGWHQFRIQQNGKNSSRHMTYLSISGFEIYGAVKGVSHDPPGCAYKKERKGLQVQVTTGANKQMVPGTRVVRGVDWKWRNQDSRSVGTVSSPIQNETSSANRSRYNLNHKSFTHTNNEKSQRSVLSMMRAFHSRKDSKRSQKSGKNLPDVGRSDPAVVRSESASSSSSYGDDFLYLDEDTEEEKKQERSCAPELDGRTCRLGVYKSSPAPSLVQRRIRKLLNEVGVILKTSRTGVDTNRPSAAFTTTPTGNSHLLPPGEPVSASVSVPNLSSSEAASRMMESFVRSITRAPAILNVNDLSNIDEFQYEHNSPSLGYKGRFSVSSPLTSAQSVPNLSAPVTVASNSSSPSIVSSHSVLQAITQALVTNANNESEAVSDLFRCLVEDLPTCDPTSSSHSDIFTELDDENDEDENEEDEEFDQLMMQQAEEEVTVAISSYTWDDDHVIKRNLPALIPAFDPRPGRMNLLQTVDLEIPPPGSNETKDNTKNVLPTNQPKKLQLYLKGINLNKETIQIPLEKGCTMLNGVQKLMLNHSSSTKSSNLRKLWDTTYTIVYSEVKNSSKFNSCIKVQQWTPDFLVSHLTSGKLTKHEVLEYLKQNATKAFISRWNLSKDSTAAQIMQAFNEFYWDPTNQLKPSNHKTTICAKDVHDVLELLKTLYAMYGDDDIILTEDLICKKLNTKLYQQIEDVVCLSCHALPEWCNFVMKNYSFLFNFDVRNKFFSSTAFGPSRSIVWMQNSSSSQLDRSMAAASMRRDDPSGFHDLMQLGRLRHERVKVPREEETLLDWAINVLDLHAEKKSMLEVEFIGEEGTGLGPTLEFYSLVAAELQRKELGMWLVDDNFIQVDPPEVHGMKRFDYYVQKSGGLFPSPLPQNNIDQVVKLFHFLGILLAKCLQDARLIDLPLSKTFLKLMCSEQQSSAVEQSRFPTFLDILEFCLNDVSTSCSGHFHQIKMNLIKFGYQCILKFFISNIKNMKIITFVILLVIFLLIKLFRHTFLSKLLELCDVRDSILCDLSLTDVEKTSQLNELYLEYNGTKCKVEDLGLTFQFLPSSSVYNYTSYPLTKEGANIDLNLENARQYVNLTLNFYFKVGLEKQMAAFTEGFNRVFPISNLLLFTPDELHLNLCGDQTPQWSRDDVLAYTEPRLGFTKESSLNSRGFLHLVNVICDLTGHERKSFLQFATGCSSLPPGGLANLSPRLTIVRKVDSGDGSYPSVNTCVHYLKLPDYSTEAILKERLLAATREKGFHLN
The following text describes a protein:
Function:
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
Subcellular Localization:
Chromosome. Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MNARGKNGPVFIKTYSKRMRKLEPWISPDLRKAAFSFSSTFSSDQSIQETPKPKKRKIKETSSRTAKTKVMAAIKENKSDEENYSPSLPSRKKIHAKPSVKTTAMRKPRTTKRAKKSTQLNLSSSENDDDSIMINHVSSKTAANECAGNDKKVLNPPYLGKFVTSRRRPLPPIQTKQIAVLHHTLNSSDDFLPSSFQNKRRKTVCMKNYDSNKHAARKCLQNRVPLAEVSFNDSDDQHLPSKCPLLSSTPSVVCRQLKNLPEPSISEISSLSFDESGQPAENNNNSNGLDYVKECDIIPQANTKQQLQNPGVSSERVIELKEGEKDVTEKRKDDYREMVQHKRGFSVAMSAQTHTGFGCVSPQSQLQSLEEELKERCHKVETAVMLKKINISDHSSLLGCSKKQEERTALNSLESIMPAEILNSQTYVTVSSSCSTPSKASIYFSSSKSLSPSHLPEANQSLIERLKAECLLSSLAVCIPRLDLGMYSFIPHGVTKAPCTDKDSATSPTLKKAEHVMPDSPINHRTPGNLKAVVQHLFLPLQLPTVSPPASVANSKTRPPVVTKERAGTGTGRKVCVSGLNVSRWSKKGAGEFQDKRRKREGRTKAASGDYSSWGSMLSTGADTFVKESACGMVQGTSGMSLAVTPLRLEQMNLSSFLANFTPDNLTTHSWGRLKAALSLHKKKTAFPTPRRFAQSHLKSPGIGFPADNSLDLFASPFCTPSRMKSSQMLQSTMNTPMTTFQEDISDAEKVYQECQQSGPLSFSDCIPPARMKHLNKIGEGTFGEVFSTINDSNESVALKIIPVEGSQQVNGEHQKTFGEILHEIIISKELSSLNLKEFNKSDGFIGLNNLHCVRGCYPEALLKAWDKFDHQKGSENDRPDFFDDEQLFLILEFEFGGSDLENMNGKLSSMAQAKSVLHQVTASLAVAEQALCFEHRDLHWGNILVKNVKHKHNEFILNGTVHCIETRGVHVNIIDYSLSRLEIDGLTVSCDISSDEELFMGQGDYQFEIYRLMKKENKNCWSAYNPHSNVLWLHYLADKLLSMNYRNKTQSSQQRTLKSALNAFKSEIMNYPSATEALMKCSFFQ
The following text describes a protein:
Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MPAEKRSSQPRIVRTYEFPTKPEKQTLGQYLYNSQDGKILGRTSKGWAQLLFFYACFYTVLAALFAICMQGLLVTLNHQYPKWQLDESRIGTNPGVSYRPQPVEAEGINSIQYVAANKSDVAVWVNMLNDFLAPYADHTLLPGGGKNQVICDFNTPPTAGNVCAFDVKNLGPCSAAAGYSYNRSAPCIFIKLNRIYGWQPEFYEDVDDLPTDMPDDLASHIRSLPAPDRRQVWVTCKELTTTDENQLGPIEYLPSQGFPAYYYPYMNIDGYLSPLVAVHLARPKPKTTISIECRAWAKNIIYRGGSRDRAGSVQLFLRID
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MQSSYQSMRKTQEMSGDRSRDGERRLSLPEDIPLPVEAGIGTQSDSSERESCPSGDSRMQSSHQSMRKTQEMSGDRSCDGVRHLPEDFPLEAGIGTQSYSSERESCPSEYDSCLIPSQVAYFHEKQAADRETLDATTSSHEPGGMDIDRNEDITMEYDEMINQSSQICAKGSDQNDPSCSLTKEKTFLCCVCSKGFAHSPSLYRHKRTHGGEKPHECTFCKKRFLYMNSLKEHLRIHTGEKPYRCTVCDKGFHTSGNLAQHMTVHTGKKRYECKFCDKKYRRSNGLVEHMRTHTNEKPYQCKLCDKKYSHNSSLGLHMRTHTGEKPYQCMYCNVSFSRVEQLSRHIVTHTGERPFECSLCSKTFSERGYLTEHQRVHTGEKPYFCSICEKRFTSNSYCKRHMRIHTGENPFLCSVCGKSFREKSTHTKHMTTHSGEKPHVCLICNKAFSNTSGLSRHNKIHTGERPYECSFCKKTFSQTHHLSRHIKIHTGERPFECSVCSKTFSERGYLTEHQRVHTGEKPYFCSICEKRFTSNSCCKRHMRIHTGEKPFPCSVCDKSFREKSTCKVHMKTHT
The following text describes a protein:
Function:
Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions.
Sequence:
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKTVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALAAMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCNAQTEAFAEWVKASPHDDDKPILLPGEWEVNTRRERQKQGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS
The following text describes a protein:
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Localization:
Nucleus.
Sequence:
MMKAANNGAAAFGEVERPDDKEGGGGGGGGRGRKNNNADDDEGNVSYRGEEDEDEEFARKNRLGLNKRGGDDDEECPRGVDLDFDDDDIEKGDEWEHEEIFTDDDEAVGNDPEEREDLLAPEIPAPPEIKQAHKSIGFFFNLILKTPKTCYAYIHKLISLCGWEPRWLPNIQDCEEHSAQSAKNGVSFNPSKHHNPNKKTISKDSSKKETRSPLLDCSLCGATVRILDFIHVNRPSRFSPNNIDVPEASKNIVITHGISAATGINGWVEAEQQTEDIDEAATT
The following text describes a protein:
Function:
Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function.
Subcellular Localization:
Lysosome membrane; Multi-pass membrane protein.
Domain:
The di-leucine motif mediates lysosomal localization.
Sequence:
MKTGGLSDFADFGEEDANCTQGIQWIKDVFTDCVDTDLKLLGFIIGLISLALWLIPLFPQLWQNYKTKKCEGLSLAFLFFWLVGDTCNMLGAILTNQQPIQKIIGVYYIIQDLVLWTQYGYYLKIYNRPTTSSARSNTIVVPVLALASVGSFFVFESALPPVGDHRVKRSFLESLNHQEGLPLEGILKMWPIFTSYTDMLGYIIGSMAAVCYFGGRIPQIIKNYRHSSCEGLSLTMFYIIVAANFTYGISVLLATTSWLYLLRHLPWLAGSLGCCCFDAVIISQYYLYRPKTPLAEDTERAGLLNSQDDSD
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Sequence:
MNSNMTVTKRCGARETIDLDKIHRVITWAAKGLKNVSVSEVELRTHLQFFDGIPTEAIHETIIKSAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPPKLYDHVTKLVELGKYDMHILQDYTREELDIMDTYIDHWRDMNFSYAAVKQLEGKYLVQNRVTHEIYESAQFLYILVAACLFARYPKETRLQYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINATASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLNKLMYQRLIKGESISLFSPSDVPGLYDAFFEDQAEFERLYLQYEQDSSIRKKTLKAVDLFSLMMQERASTGRIYIQNVDHCNTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPNGEIALCTLSALNLGTITDLAELEPLADLAVRALDNLLDYQDYPIKAAQISSMNRRTLGIGVINFANYLAKNGMKYSDGSANNLTHKTFEAIQFYLLKASMNLAKEKGACPLFNETTYAQGILPIDTYKRDLDKICSEPLHLDWEALRSDIKEYGLRNSTLSALMPSETSSQISNATNGIEPPRGLISVKASKDGQLKQVVPDFDTLKNNYELLWQMPSNEGYLQLVGIMQKFVDQAISANTNYDPARFEGRKVPMQTLLKDLLNAYKLGVKTLYYHNTRDGASDQHDDITNIEKEDDGCAGGACKI
The following text describes a protein:
Function:
Inhibitor of fungal polygalacturonase. It is an important factor for plant resistance to phytopathogenic fungi.
Subcellular Localization:
Secreted, cell wall. Membrane; Peripheral membrane protein.
Sequence:
MDKTATLCLLFLFTFLTTCLSKDLCNQNDKNTLLKIKKSLNNPYHLASWDPQTDCCSWYCLECGDATVNHRVTALTIFSGQISGQIPAEVGDLPYLETLVFRKLSNLTGTIQPTIAKLKNLRMLRLSWTNLTGPIPDFISQLKNLEFLELSFNDLSGSIPSSLSTLPKILALELSRNKLTGSIPESFGSFPGTVPDLRLSHNQLSGPIPKSLGNIDFNRIDLSRNKLQGDASMLFGSNKTTWSIDLSRNMFQFDISKVDIPKTLGILDLNHNGITGNIPVQWTEAPLQFFNVSYNKLCGHIPTGGKLQTFDSYSYFHNKCLCGAPLEICK
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Nucleus.
Sequence:
MSDLSQTIRAFIVGSFQQLPPSIVDDLANGSVSLLGIVRLLGEYLTSQEEDTRTRAVQLLSYITCHFLDTSAPLPPSKQPLASIFTIQAVRTLSSFFADKIADGVLISDNFVRSANAPEVVPDTASSARKNEAEQKTLQGSAMLVSSLNALTVLSACKATTAASADTAPTSPPPVKGFGQEQAHAVADALFSHVIATNHPQSLRFIIFRLLDSLVAHHRDALKAYRSSTSSAADEQPTQSTSATPHPMQVDPVADADALISGSETCQGKDFLQGYVKMVQGEKDPRNLMVLFGVDKVLLTEWVMDREMTERFFDITFCYFPITFRPPPDDPYGITSDDLKVALRAAICASPALAPHGYPLLLEKLSAAGGAAKLDTLRTLIAAMPVYGRAAALANATKLWEGLKIEIFHATDDETGDLAVDTLTILLHVLYHGVDPPEGIAPRMVHDCLVELEEPGKSLAKAAIRVLSCLVRASASTAYLAVYGFMDQMIKMFADPEDLAQRTPILAGIGELLDALAKVYRHAELARANEDGNTKTKPSSAASEIGSGQLLPSTAPGRSYTGDNRPLDPFLSELLSCLSNGLRSTSYRRSAMLVFSSIVSISILSSNGNGTGTGTTGTQNDEVSLSKSIKPLLDFDELSFLTRQVASLLTSSIGDDVREEALCAIEVISNERTASTLAAINPTAKIIEQVVLPVLLEKLPDRIQLFDDPEQRTTGNAMDDTAAELDLIKASIRRSLGALSRLCVAPFLFEAVVVKLFTKLELCCRTGVHDGPSSERDIVLGVTKTNEEGKSSSMLNEQLSALHEANLGYARGLILTLQTMVDLKKQNGHLDLVKYAHTLPSRLVSLTLSSLGSATDQANAEVSIAAHPAVVADSAALLGTFVKLLDTSRQREFLASLNQTFVQRQSTFVESGENVEGASLIAANSPLEQSFAPFLPSPASQNDHFAMASRNAVALFAAAIVASGPAAGVVVLSASADATMSKHDAALASLSLLLDWTLAAASSNADKGSTNYTMGQTSQALQLNSAFWMAVSLTNKFIDETQPAFLDLLDTFWGTHIKNPSTTACSARQRRVALQMWMWLSRALVIKSSKLSEAMLNRVLIEIFDDVASGIAGQKRATQLVATASQPAKTEESVDWKFARAAARDLSTIVGVGEDGITTKENGFTVRLLWKQKLFSLLLPRLLESYSSAAKLAHRHNHVDGEHCSHSHGEADVDAKTIYLVSLAGLLPSLPSTMLVERLEGVFPLLIQALALPDSKARSAAANAITVASEVGKKLAPPSSLPPSAPQFDPTALIAAHLNSIVTKLLCNIEPTPYTPPATRIAALRTLTSLAAKVPEDDEATHSTQRSDSGLQHHHLHPLRNLVLKHLGKHKIGIDDKIRSVRSYAVDARDAWFAISET
The following text describes a protein:
Function:
Class B beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, cephalosporins and carbapenems. Acts via hydrolysis of the beta-lactam ring. Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities.
Subcellular Localization:
Periplasm.
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
The following text describes a protein:
Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Sequence:
MSRILKIGSRKSALAKLQTYLVLGALKKKFPEIQVELFFREASGDQDLQTPLWKMGTKGVFTQDLTADLVEKKVDIVIHSWKDLDLEGHPDTTIIGVLDRADQRDVLLWKKSSLSKYSPSVLKIHTSSPRREYNLRKFLSFSLPSRYTNSSLVFLPIRGNIQTRIRKWKESDSDGLVLAKAALDRLLSEDFFNSDELEYQEIRKFLKDSMDESVYQIFPLSLNPTAPGQGAIAAEVRTEDNWVLDRIRTLSKSEVVLAVEEERKILKRFGGGCHQKIGVSILQKAYGKILYQRGLSDSGEVLEVEEQFSEIFAPPADSVSKVYPVPGEAVKQKRTPLDSSNGLIFSEDGQNNKTIFPTELILKDWLVTRGNAFPNLSPALEHTGLIWTSGLKTWFQLAQRDIWVHGSLDALGEDELPKHSIFGKPLDFIKCTHLGSTEIASGLGRVLTYQTQAMEDHPDLSEKTHFFWMSASQFDKALSIFPQICNGFHACGPGITYSHIRKVLGESANLSIFIRYESWLASLGLEEFKGKKIGNQTEKNSP
The following text describes a protein:
Function:
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
Subcellular Localization:
Cytoplasm. Secreted.
Sequence:
MTSLLLLLFLPFSMLLSQGESFLGIPHRPHKKELEDTSSNEEPCHFPFRYQRQMHYSCIPGNFIIPRHWCATTENYDRDHKWKYCREEERPQRHCDPNPCQNGGICEARKIGFHCICRPGFHGRNCERESCFGAQRPPHIGMKDTWLRYHQPAGLEECHCFGKDIACRPVHGKDCATNPCLNGGLCLELKSSWVCGCPEGFSGSLCDIDHNQTCYNGNGELYRGTARNGVTGALCVPWDSPILHSEYSSNMNNAVSLGLGAHPFCRNPDNDNQPWCYVLHNMQLTWEYCNVTRCLPPPAGSMVQQQENEPTVSVQMSLNQTVSSSSTVSEPITITPVCGRRYTKTTSSLKRVVGGMVALSGSHPYLAALYIGDQFCGGSLIASCWILTAAHCLEFRPDVSKISVVLGQTLYNRSTKGSVKLHVQGYRLHEHYSVLTKQHDIALVQLKEKIPGHCAEFSHSISPICLPSSMKSTYDTSKQCQIAGWGHMYEGDDKLSLLLQEADIPIIPHEQCTSQQIHGNRITEGMLCAGYLDGRADACQGDSGGPLVCEEQNGATVRGIVSWGTGCAQENKPGVYTNVADYLDWIQSNMQ
The following text describes a protein:
Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular Localization:
Cytoplasm.
Sequence:
MAAPGPALCLFDVDGTLTPPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLVCKQSIQGHLGEALIQDLINYCLSYISKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFHELDKKENIRQKFVADLQKEFAGKGLTFSIGGQISFDVFPEGWDKRYCLQHVEKDGYKTIYFFGDKTMPENIGNFMRRPRTFLQCLGSWDVPPRAVGLGLPHRLGAHRLGTSQQHGRVLPGTGPYRSLAPGPRRHTVRNTENWEAEVGAGAGPAAASWGPHLDAIASVASPRGAAGGVPHCPILQEGSCGSTPPAGGGTRVSTRPPPQAPATWGSLNLDESE
The following text describes a protein:
Function:
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKVRRSRGPQGGGGRREVLETLVTRVLHDVRGLKTARWAPTLPAGTAPGGGRAGSAWSLAWGRRGERLWCGGGESLCPLQTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ
The following text describes a protein:
Function:
Involved in pharynx morphogenesis probably by remodeling the basement membrane; [Isoform a]: Plays a role in embryogenesis, the second phase of distal cell tip migration and is required for distribution of the metalloproteinase, mig-17, during organogenesis; [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MRLLLFSAALLLCSVPTWAFSLSSFFGSDVAQKPYLHPNSPPERDPASSRMKRQAYQVYVDGDVSVTVDKSGQKETGNWGPWVPENECSRSCGGGVQLEKRQCSGDCTGASVRYISCNLNACESGTDFRAEQCSKFNDEALDGNYHKWTPYKGKNKCELVCKPESGNFYYKWADKVVDGTKCDSKSNDICVDGECLPVGCDGKLGSSLKFDKCGKCDGDGSTCKTIEGRFDERNLSPGYHDIIKLPEGATNIKIQEARKSTNNLALKNGSDHFYLNGNGLIQVEKEVEVGGTIFVYDDAEPETLSAQGPLSEELTVALLFRKGSRDTAIKYEFSIPLEEEVDYMYKFDNWTPCSVSCGKGVQTRNLYCIDGKNKGRVEDDLCEENNATKPEFEKSCETVDCEAEWFTGDWESCSSTCGDQGQQYRVVYCHQVFANGRRVTVEDGNCTVERPPVKQTCNRFACPEWQAGPWSACSEKCGDAFQYRSVTCRSEKEGEEGKLLAADACPADEQEKFDTERTCNLGPCEGLTFVTGEWNLCTRCNDTEETREVTCKDSQGRAYPLEKCLVDNSTEIPTDTRSCATQPPCEYEWTVSEWSKCTTECGHGHKTRRVICAIHQNGGLEVVDEGHCQAEKPEGKTNCTNEEKCTGTWYTSSWSECTAECGGGSQDRVAVCLNYDKKPVPEWCDEAVKPSEKQDCNVDDCPTCVDSEFGCCPDNSTFATGEFNFGCSNCSETEFGCCADNVTVATGPNSKGCEEFVESPLNLEADVANADAEASGDAPELCSVTNENGEAVDVECATIAPITALLGDGELIGNDTDASNETIHCSKTEFGCCPDWYTAASGKGNEGCPSFTLGGCNETQFGCCHDDVTLARGANLEGCGEPSCAASLYGCCKDRKTIAFGPHYSGCERSSFPCELSDFGCCPDGETAALGKNGTGCGENCLTTKFGCCPDGKTTAKGSHNEGCGCEFAQYGCCPDGKSVAKGAGFYGCPESCAQSQFGCCPDGKTRARGENKEGCPCQYTRYGCCPDGETTALGPRNDGCDNCRYAKHGCCPDGETKALGPDGAGCPPTTTPPFLMGGTVAPHKIAACNQTQESGTVCGAGYKLAWHYDTTEGRCNQFWYGGCGGNDNNFASQDMCETICVEPPGKGRCYLPRVDGPLRCDQLQPRYYYDHSKKHCVAFWWRGCLGNANNFNSFEECSMFCKDVGPYDAPTTAAPPPPPQQNAQQYLPTPEVQQIEIQSAEQPQPQQPQQQQQQQQQQPQQPRQSMEDICRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRCFFVHGAQPSAARQEQAQPAAQPAQPAQPSNIVSPPQQSASPVVVPSNSKQRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVKPASEAASAGIDGAAGINSVCDEAKDTGPCTNFVTKWYYNKADGTCNRFHYGGCQGTNNRFDNEQQCKAACQNHKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCPKDDQTTTTSQPEELPSLPLVQEDPQPRPAFSLKQSFAHSRRRDAPFARSVSARHHTPDSEEERVDCYAVPDPGSCGDYRLVWHYSATSNSCRQFYYGGCAGNTNRFETRDKCETSCVAKIEERVESVSEASKSLEEVRLTDPRMDSHFGYHDPEVDQIEEEAEYVIVDTGALPELCMLPEQRGSCYDNILRWRFDSEKSQCVTFMYSGCNPNANHFTSQETCERACGKWRNVAVCELPAEHGDCQLAIPRWYHDPKTSQCQMMMWTGCGGNGNAFSSKADCESLCRVETLWSNNTDFCTLERSAGPCTDSISMWYFDSTHLDCKPFTYGGCRGNQNRFVSKEQCQQSCRPGDTKSEDICTLRPEPGPCRLGLEKYFYDPVIQSCHMFHYGGCEGNANRFDSELDCFRRCSSVKVEASESERVGQLTSASTPVIYIVNKTAIFVGNTFRIRCNSYGVLPITWYKNGGLLQFGSRITEENDDTLEIVDALTADAGVYTCIAGQDSTMSEGVEVVIKRLPGHRTTSRPMLTPSKNFSLGTPPTPSPSTVSTTPFRIYTPGSAPSDARVSRPTSNSCMDVGNASTCDLIVKNGLCGKKRYGTFCCHTCTRVHNFKF
The following text describes a protein:
Function:
Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).
Sequence:
MGVSQNEKSVILTHESGCSAEIYFYGATVVSWKQGGKERMFVSSKSAMDGSKAIRGGIPVVFPIFGPPPPSPPEYASLGQHGFARTSTWKFDSVVMDRPEGVSVRFVLPSAPPTFLHEFKLSYVVTLAPHQLSTDLHVVNSGKEKFSFQALLHNYLAVPDSSKIKITGIDKGTTYKDKVLGGKMDEWDGSTLVIDREIDRVYQKVPSREITVDDGAGSGYKVRFRGFEDCTIWNPQEATGSKMADMEDKGWDKYVCIEPGYVREFKTLSPSQELILAQTITVL
The following text describes a protein:
Function:
Involved in the assimilation of dimethylsulphoniopropionate (DMSP), an important compound in the fixation of carbon in marine phytoplankton, by catalyzing both the hydration and the hydrolysis of 3-(methylthio)acryloyl-CoA (MTA-CoA) to acetaldehyde, CO2, MeSH, and CoA.
Sequence:
MTQDVTSGYSNLDLDLRDNGVCVVTLNRPDKRNALDVATIEELVTFFSTAHRKGVRAVVLTGAGDHFCAGLDLVEHWKADRSADDFMHVCLRWHEAFNKMEYGGVPIIAALRGAVVGGGLELASAAHLRVMDQSTYFALPEGQRGIFTGGGATIRVSDMIGKYRMIDMILTGRVYQGQEAADLGLAQYITEGSSFDKAMELADKIASNLPLTNFAICSAISHMQNMSGLDAAYAEAFVGGIVNTQPAARERLEAFANKTAARVRPNS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (By similarity). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MENPLCVSIFLFYCILIQSSAHGQSLGPESFGRRSRAAETNKTPQETRTKFLLFRGETDKGCQILLNHSDTLQQCGFNSSLPLVMIVHGWLVDDILEDWVWEMVAALKSQLAQSVNVGLAEWVTLAHNHYTTAVRNTRLVGQEIAALLQWLQESVQFSPSHVHLIGYSLGAHVSGFAGSYMSRKHKIGRITGLDAAGPLFEKASLSDRLSPDDANFVDAIHTFTWEHMGLSVGMKQPIAHYDFYPNGGSYQPGCHFLELYKHFAKHGLNAITRTVKCAHERSVHLFIDSLLHADMQSMAYLCRDMDRFSQGLCLSCKKGRCNTLGYHTRQERQSKKSKSLFLVTRAQSPFKVYHYQFKIRFINQTENPVEPTFTVSFLGTRGERQKIPITLSKGITSNETYSFLITLDVDIGELIMIKFKWENRMVWSNVWNTVQTIIPWGRGSLHSGLALKSIRVKVGETQQRMTFCSENMNDLLLHPAREKTFVRCEANSETLKRKIR
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MSAALREIRFHLCQNGSSSAPLRQFVKNQIGAFQKANPSTKVLVREANGVKPIVFARFDHGHESKIGLDVSSEKEVAERVKSLIEAK
The following text describes a protein:
Function:
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDCHRFTANSQESEKFTERSCAILGGPAQIAGVQASLIRNNSDGTFSLDELRDRIRKNPDCHEPYTTLVIIENTHNMCGGKVLPLDWIEKVKNISKEYNIPVHMDGARVINAAVYLKVPVERVVRDVDTVCFCLSINKFPFLKSLYLSSLPEAFPRNRRPQRSSALAAAALSRIPPPPRLSNATRNPVPVRMQQTIGAHMDQEDQHLAEEYVQDFVLDHLESVTVKSEDKRMEEWVQRDDRCRQWDDRRIPPLSPPPDSMYPQQPMLVSMAVMNAPGTPPQTPPSNSPDNCRPPMMDEMMWFPQTVRSEPLDLRPLHCMGGEPDWERREYIPSGMIMDNGHHIIHQRPQSVCSGASTVSPRLNHNTTSGYSTCSDDLGLDDQMLMTLSVRELNKRLHGCPREEVVRLKQKRRTLKNRGYAQNCRSKRLQQRHDLEQTNRSLQSELHRIKIELARVSQERDLLKQRLNLGRQQVQHLNSEGQSSPEFYL
The following text describes a protein:
Function:
Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating myog levels. Binds to a huge amount of mRNAs (By similarity). Required for embryonic heart development, sarcomer and M-band formation in striated muscles.
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The RRM domain is necessary for mRNA stability and mRNA translation regulation.
Sequence:
MHTTQKDTTYTKIFVGGLPYHTTDSSLRKYFEVFGEIEEAVVITDRQTGKSRGYGFVTMADRSAADRACKDPNPIIDGRKANVNLAYLGAKPRVMQPGFTFGVPQIHPAFIQRPYGIPTHYVYPQAFMQPSVVIPHIQPTATSATASSPYIDYTGAAYAQYASAATAAAAAAYEQYPYAASPAATGYVAAAGYGYAMQQPLATAAPGSAAAAAAAFGQYQPQQLQAERMQ
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MPPRNAAQAAAPAAAMAMERPRRGKANYAAPTKLKEASSSSSDSDSDSEVEVIEDKQARCARPPAAGKAAAAPATRGRGRGAAAASTRGRGAAAGGRGRGQQVAPQEAEDVEASECEEDNEGEDESNEQEEEEEGEEEEEEAEEEEEEPKDKAVAAQRERRAAAATAAMAARGRGSGRGAAAAASRPTRGRRGAAAAANNSSDDSSDDEDGGEDSEEEEEGSSSGEEEEQEQAAAPAAARRGRGRGAAGAAAAAGAAAGGGGRKRAAPLVAPTAAESRKRLFDLLERRIGGATAGGGHGAGCGEGGSGGGAARLQYVDVPAKNPAKKAKLLEDLKKQFDEWHSRMRSNFSVLLYGFGSKRALLDDFARRLAGPLNRGDAAVLVYYGYNPRCTAKDVVTGVASALLQRSFRHLTSGAGAAAAAAAASSAAAGAAGAAAPAPAGGGGGVLGALRGLVEEVRREAADRHVFVVIHNLDGPGLRGDVSLLSALASCPQVHLVASVDHAMSPLLWDSADAARFRWQYINATTFQPYIAETAGAQSVLMGAFKSGVVTAGAGTVLRSLVLGAQEVFKVLAEYLLEDDQCEGVAFAHLYRMCRERFLVRDERVLRQHLVEFVDHQLVRYRSATDNSGELLSIPMERPDLQAVLDDLAAARAE
The following text describes a protein:
Function:
Tubulin-folding protein; involved in the final step of the tubulin folding pathway.
Sequence:
MSNNNNNNNNNNDEENSKLDIVKKQFQEKEKQRLQSKLEKREISNKEQIDQSSSNIASETLLLINNLSDDIENRLNEISNNTNENKAEDLKESYNQMEESLSEINSITTMSSHILTSYDVKSILENIDNLRKQIDKSKEKYMPKQKLSLTRKKTKTTTVSTKTTSSKEDTNETFNNNNNNNNDNDNTDNNNNKISTEPIFNLINIKGFKNKELFYPPKKEEEIGNQDINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNSINDLFISDLTDCTVILDMKVLTALKINNLVNCKIRANSPIDGSIFIDNCINSIFSLVSRQIRIHYCTDCQFNIFVKSNPIIEGSKQIKFSSYLQNLKQQQQQQQQQEQEKVLSSFDNKRFKEYSFDLESNNIDSDKWKLVNDFDWIQQKQSPNWSLVEY