lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Invertase that cleaves sucrose into glucose and fructose.
Sequence:
MDFMSTIITQDDGYSISKGKGAETKSSSSSRKKMNHNFNINNNSNKEKMKTSSSCNDKSVSEIFKQKPVLQKLLLQGNLMLLMLVTGIVILPHLADGYGAETEAEPSRLKWPIKLLKLFVPLLRFLITSWLLLMLRSLSPIGGSGSFLEGDDNNIRLNAKAIRSALNEMDQLLPLWTPHYPMEMEVKYRLIGLVSHIGSNIQCGHCVAHVYKEGRWLTVASIKMNRPEIVENAVKVAERRIERDKWPKYYDTKRGRFIGKQARLFQTWSIAGYIIAKQLLANPDAANSMIMESRAVSIESLCVISGKLMSIVVQCKSFGDKDLDLRLANPLHLQNLLKDPRFLDSRIVLLHASYPFSREASHLASIYH
The following text describes a protein:
Function:
Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.
Subcellular Localization:
Mitochondrion intermembrane space.
Domain:
The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of chchd4/mia40 in mitochondria.
Sequence:
MSYCKQEGKDCIIFVTKEDHEAPSNAELVEDDPNDPYEDHGLILPNGDINWNCPCLGGMASGPCGQQFKDAFSCFHYSKEEIKGSDCVENFRGMQECMQKYPELYPQEDDNDSAPSGGANTAPTDSLPASSTDSTAAAATENPATS
The following text describes a protein:
Function:
May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex.
Subcellular Localization:
Nucleus.
Sequence:
MSSDESDAASNKEEDTTLSDDDGSDVEIKNSKKDRKRKLASESEKSGSDDDDDDDDDEDENVTSKKSKKQKRKNKAPSGRDFLAWDVEVDDEDEDDDNDYDDEDDPSMNAMNEREEAERAMKEMELSQRNRDRYKFQNMTEDEVQKYFENKYKGDKNDSQYDDEDSAMDDISKNSHLPSTKDPNLWIVKCRMGEEKLVAMHLMRKCLAVEHTNEPFQIKSVVVKEGLKGMIYIEAFKQSHVMSAIEGFSALNQFTITMVPIKDMVDVLRVVKDIPQLKLGSYVRLKRTMYKDDLAVVDLVDIAQNRVNLKLIPRVDYQKRRGAMRTDADKNYKLKRRPMPKLFDQDTIKEVGGEIVTDGDFLVFEGNHFRRGFLYKYFPINAIQADGVKPTLGELEKFQESSDDLKRELETASLKDTENPFVPGDIVEVKAGELVNLRGKVMTVDGTKVVMMPDQEDLKEAITLNAHELRKYFKEGDHAKVISGRYEGHTGLIVRVKDSTAIVLSDLGMEELKVRVRDLQLCADVTTGVDSLGQFQYHDLVQLDHTGNVGVIVRLEKEHLEVLNMHGVVNRIKPQAIIAKKDVRFAKVLDSQNNSIEAKDLVKVIGGPNAKERETDEDPVGEVLYAFRGTVFVYSRKVTKNGGVLVCKPKQLILQGAKKTTSTPMVSRMASPNPMASPRHSSGGMTPRSPQDGMSSRGSSGGQTPRQGGGGGRGGHFGTANQQKVRRDLTLIGKNVRIIKGPMKGHFGIVRDATEDTVRVELHTQCRTISVDRARVMVVGDTGITAGSGGGSSFYSSSKTPMRDSGKTPMYGSKTPMYGAQTPMYGSMTPAYDGGRTPAYGEGGRTPAYGSKTPAYGDLDEHSSSRTPAYGNDSSRTPAYGSADGARTPAYGSTEGGRTPAYGSMDNSRTPAYDDSGRTPGYESMPSRTPNYDSSSKTPAYPESEHSARTPAYNNDYDIPLSPAYEPDAPEAYDNAPARTPAFVSRTPGYDTYENSSPTYEPDAATKVEEDIGDTSSPTYDSPPHSYVVPTPGAMLNPATPGAYHVDTPGFAAPMTPGSGGAYDQYVAPSPFAGYDSNNYNNADGAIEQIPDHFLAQGVWIVQNLCVQIKDHEGRFNGREAIIKDVTDGKVDVYMPDHKCNLEVDFDQLTPMKPQPGDDARVIFGQDAGHSGQLVSMDGFEAVIRSQEDMSDMRVINIGLCCKMHSET
The following text describes a protein:
Function:
Hydrolyzes alpha-1,2-linked fucose. Also active on fucosylated xyloglucan oligosaccharides. No activity with 3-fucosyllactose, p-nitrophenyl-alpha-I-fucopyranoside, lacto-N-fucopentaose II, lacto-N-fucopentaose III or alpha 1,6-fucosylated chitopentaose. Involved in apoplastic xyloglucan metabolism.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MAEKSSFFVHFSCLLLLLTIIITCGEGVRNPVRPRSSERRALMDGQDLSRPLKLTFGGPSRNWTDAIPIGNGRLGATIWGGVSSEILNINEDTIWTGVPADYTNQKAPEALAEVRRLVDERNYAEATSEAVKLSGQPSDVYQIVGDLNLEFDSSHRKYTQASYRRELDLETAVAKVSYSVGAVDFSREFFASNPDQVIIAKIYASKPGSLSFKVSFDSELHHHSETNPKANQILMRGSCRPKRLPVNLKKSINATNIPYDDHKGLQFASILEVRVSNGGSVSSLGGKKLSVEKADWAVLLLAASSNFDGPFTMPVDSKIDPAKECVNRISSVQKYSYSDLYARHLGDYQKLFNRVSLHLSGSSTNETVQQATSTAERVRSFKTDQDPSLVELLFQYGRYLLISSSRPGTQVANLQGIWNRDIQPPWDGAPHLNINLQMNYWHSLPGNIRECQEPLFDYMSALAINGRKTAQVNYGASGWVAHQVSDIWAKTSPDRGEAVWALWPMGGAWLCTHAWEHYTYTMDKEFLKKKGYPLLEGCTSFLLDWLIKGKDGFLQTNPSTSPEHMFTAPIGKPASVSYSSTMDIAIIKEVFADIVSASEILGKTNDTLIGKVIAAQAKLPPTRISKDGSIREWAEDFEDPEVHHRHVSHLFGLFPGHTITVEKSPELAKAVEATLKKRGEEGPGWSTTWKAALWARLHNSEHAYRMVTHIFDLVDPLNERNYEGGLYSNMFTAHPPFQIDANFGFAAAVAEMLVQSTTKDLYLLPALPADKWPNGIVNGLRARGGVTVSIKWMEGNLVEFGLWSEQIVSTRIVYRGISAAAELLPGKVFTFDKDLRCIRTDKL
The following text describes a protein:
Function:
Involved in positioning the proximal bud pole signal.
Miscellaneous:
MISCELLANEOUS: Present with 3250 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MPSESSVSIYKLDQLEYQYHYLTKSLQKFEPRYPKTAKLYNCIGKKNKKKIEKLLNSLELKTLDKELDESYSKLLNNKIHYYETHLSKCIKEQIQKISKKNSSKVKDAQKNKSPSIDIEKMLATQLSLDDLALFMTRFRLIKILHQRIKQKSKKIEGDTNNKTWLNNNDYSGYINDKTSKWNPSNIWNEVITKLPSCEKLNALIGQSKIVQNLTESFDLSICLIFGFDVSAMKAKKYGAREKTANANQTHSNIDYDTDDGNEKNAIDSKSNAIGAQTQSNKETTSDNEDLLIKEYEGMLGSSGDEGEGGGYLNPNINYNEVTDEEPSEASSDEDDSDERFSDSEENEPRRKKPKLHNLPELMAGYYSGNDTEEESDEDNKNVKGKKKKRDTAEDRTAREQMSNEPKRKNRRGQRARRKIWEKKYGSQAKHVQRELEKEMEDRKQRQIEYEARVAKREAKAASLEASRSREREDRRTETNNKKEKESASTGEEHPSWIAKRLAEEKLQKAKFEGKKIKFD
The following text describes a protein:
Function:
Required for underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes. Functions by promoting the localization and retention of Rif1 to active DNA replication forks where Rif1 inhibits replication fork progression. Controls chromatin organization in polytene chromosomes.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to the DNA replication forks and heterochromatin in amplifying ovarian follicle cells. Binds to polytene chromosomes from salivary glands. Localized at late-replicating intercalary heterochromatin and pericentric heterochromatin. Colocalizes with many Polycomb Group proteins binding sites on polytene chromosomes.
Domain:
The SNF2-like region is essential for localization to DNA replication forks and for promoting underreplication. It is not required for localization to heterochromatin.
Sequence:
MYHFVSEQTPEVRLTDEALVTSHVTQYLKSFQLDAVRFVYDRLAKREFCILNDESGLGKVATVAALLSALPPAKKTLVVLQNDEQLLTGWRFHLDTLTDLQVYIIQGVQDTTDSPHSVYLAKWSQLRSIGDLSRLKFDYIMVDNRGHSLNNSFCTSMLLKQFEGRVNVLISSVDVTSDVRLLYNVLRLGGRLEHQYKSFASFDRKFHLPDPKEVFSKRIDLEEYYKQRGFLSEYIKDFRLRRFRHQFDKSLPLVAPEQYKHNLNLWLASKNSQSTISGSDVCSTIASIDNNPAQQNKTGLFEETDRLSEHSVDDVAMSPLIFEYSESDDEPLTVEPDADQNPVLVVSSDDCEIVTPPSTPQNRTPSLNESPRTKSKKKFSKKTSPRKKADLTDSEEDDEATDNMPPRKRTRAATVHLTPKTRRLNVRILRVSLDTLSTPPPSRTTTAIVTPKTEPTARRKNLKKRTVSPVDVGRPATRGMQRLTRSAETKINSKYLKHRSLDDVKRSFPRRVKLEGNQTPRSSKQIVKQEPKSKVGQEKKQKTVDVPAQGTAKRKPGRPRKCQTKTEDLGKTKTKPNSKHLPPTPQVLSGSSLSSEYMQCAQRIPDNLDAIESPAFRVPFTPQQTPMLLTLPSTHNLLNDSEVVSIPLYKDPVETVVINSSHDECSPQDPSQSRRTKALKRKRKPVTSVNSSFGGGLGLPPAKRSANKSPDLFSISSEHSQIPLAQPRPSSPFEGFKIFGSEVKQFQQQLAKVNISVPKKKRDRSCLDILEQMFEPRQQQSAKTSPKVLPTLPLTQKDDAESTITQRRRTLLEDDFFEITNNGQFGSRMRLNSSGEVSPVQPDQQSVRPSQANKITNYLIGSGITQERTQPSNGNRNSILASLRKSPKSPKQGAKSTQATKLTRWFGSVFGGGASQTSSVESVSAPSTPVNSSTSAAACQTRSARSGGASGPTKRKRLELFK
The following text describes a protein:
Function:
RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
Sequence:
MVGVKRPVDAGDERNGKRTKTKTVSATTKKSKAAPVKKSAPQKSSKKDVKSGKKDKKSKRKVEEEEDFDDDDEDDFDIDDIADSEDDEDEDVEMGSSASDDDEDGDIQQEKKQNTKDSVASTKAEPLKNTNSSREAHAKQKTLLQERKAAKPNADIIARSKQLWERLRRKSHVPLEERKKLIAELFEIINGRVRDFVFKHDAVRVIQTALKYANIDQRKQIAHELKGHYNELAQSRYAKFLVGKLLVHGDTEVRDLIIPEFYGHVKRLIRHPEGSWILDDIYRTVATKQQKATLLREWYGPEFSIFKDEQASADLSEILEKNPEKRLPIMHFLHEMINQLVQKRTTGFTMLHDAMLQYFLNTKPGSSEANEFIELLKGDEEGDLLKNLAFTKSGSRVMCLSLAYSNAKDRKLLTRAYRDTIKMMAADLHGHMVLLAAYEVIDDTKLTSKLIFPELLNQGMEEEARNEELLYQVNDLTARIPILFPFAGDRVKWLVPEVDQEVLKEIREIRKETSKKEPAVRRRELVKAASPTLLSFIAARAESLLETSFGCQFIAEVLFDADGDKMPALSAVASAAKVKSDMKDSPFFGRLLKSLVQGGRFNPAEKVVEKVQPPLNFHALLYEQIKDEIMTWATGPNTFVVVALTESDEFAKKDELLKTLKKGKKALEQAAAESGKDEKKKKAGPTSSGAKLLLEKIR
The following text describes a protein:
Function:
Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity.
Subcellular Localization:
Secreted.
Sequence:
HALDTPHFPQELTSALSKNICITFFSGMFKNVESVAEIFDSLGPSFKQDQA
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in E.coli and M.smegmatis inhibits translation, cell growth and colony formation. Its toxic effects on cell growth and colony formation are neutralized by coexpression with cognate antitoxin VapB11; the effect on translation has not been tested but is probably also neutralized.
Sequence:
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAAGIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR
The following text describes a protein:
Function:
May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. May resolve the topoisomerase II (top-2) DPCs. Limits replication stress and DNA double-strand breaks.
Subcellular Localization:
Chromosome. Note=Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase. Colocalizes with top-2 on condensed chromosomes during embryonic cell divisions.
Sequence:
MPTPFRDLHNKSNASASSYETAWSSSFSSRRSTNNDSKSNLKEIKDEPISNLDESISILENNISMMSVSSPTPAYRTPARVIAREAPMTPGDRLLQKIEKEDERDMLRQLYPEMFDSNQKPRQKPKEVKKALKVESLSDYENDDKENVPPCGKPSKEKEEKKQRTKKIVISSDSEDDGNFENYLKTLREKPTEPAKPERKIPVKKDFVVDDDYISEESSEEESEEEEEDVDDEEYRESSPEVEAKISYSDRKQKKRPTDEEEWFLLSLSEKFSGPIHEDAKVYIKETSLRYKKHRESLLTRLQDILVRRIFSAIPSEKLKVIWNARLRKSAGQCRNHSNGNSTVEMSPVVCTTAERVRDTLIHELCHAATWVVDRLHKEGHGPGWKRWGARCSSVFKSLPFIERCHSYEIEAKFFYVCEKDGCDVEIKRQSKSLDTSRKACGRCFGRFILYRYCRRTNTRIRIEDPKAKPVGPILSNSSKPSPPAPRRIVSEHPEGFKEYSEEHYWKYTAQGLKHSDVMGKLLKEFKELKQL
The following text describes a protein:
Function:
Transposase responsible for transposition of the IS200 insertion sequence (IS) element. Transposition occurs in 2 main steps, excision from the donor DNA 'top strand' into a single strand circle and its subsequent reinsertion into the DNA target. This increases the copy number of the IS.
Miscellaneous:
MISCELLANEOUS: Belongs to the IS200/IS605 insertion sequence (IS) element family.
Sequence:
MGDEKSLAHTRWNCKYHIVFAPKYRRQAFYGEKRRAVGSILRKLCEWKNVRILEAECCADHIHMLLEIPPKMSVSSFMGYLKGKSSLMLYEQFGDLKFKYRNREFWCRGYYVDTVGKNTAKIQDYIKHQLEEDKMGEQLSIPYPGSPFTGRK
The following text describes a protein:
Function:
Component of the plant cell wall polysaccharide acetylation pathway. Does not directly catalyze O-acetylation of xyloglucan but exhibits weak acetylesterase activity in vitro.
Subcellular Localization:
Golgi apparatus membrane; Single-pass membrane protein.
Sequence:
MLGAIHLGVLAACFVLFVPMAMAGWHLSRNKMLFFSGALFISLAVCVHLTPYFPSVSDIVASVSSVVVYDHRISCINEVNQIVWDVKPVPNPESVRRNNGSTKLDYFVKNWDWMKSRKVLSCEFQKLDKFDVSDLLNGSWVVVAGDSQARFVALSLLNLVLGSDSKAMDSVRGDLFRRHSDYSIVVKEIGMKLDFVWAPYEKDLDDLVVSYKKMKKYPDVVIMGTGLWHMLHVNNASDFGFRLRQLSSHVESLVPLTPKEQEGGGSVSGRSVHLFWIGMPVLINGMLNTDEKKEKMSDTVWHEYDRSLGESKILRQMGGPLILLDIQSFTWNCGPQCTLDGMHYDSAVYDAAVHVMLNALLIESHQSL
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAQAVEEWYKQMPIITRSYLTAAVVTTIGCSLEIISPYHLYLNPKLVVKQYQFWRLITNFLYFRKMDLDFMFHMFFLARYCKLLEENSFRGRTADFFYMLLFGASVLTGIVLVGGMIPYLSASFAKIIFLSNSLTFMMVYVWSKQNPFIHMSFLGLFTFTAAYLPWVLLGFSVLVGASAWVDLLGMIAGHAYYFLEDVYPRMTGRRPLKTPSFIKAMFADESVVVARPANVRFAPPADELHRD
The following text describes a protein:
Function:
Involved in oxygen transport from the lung to the various peripheral tissues.
Sequence:
MKLAAGSIHSPSYRLRKQSWCSLQMTKPTSRTAGGRLVAMVVNMARRPYRGEIRTLFFKDSRIQTGPGTQWAAPKCAFPWPQLISPSHRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR
The following text describes a protein:
Function:
Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in sporulation.
Subcellular Localization:
Secreted.
Sequence:
MCHKMMNKFQQRLHHTTSTPLFKTCVYFSNWSVYQKKHFPQDIPIEYYTHIFYAFILIDEQTGKLKFSDEWCDLQMPQPSPNQSITGNLQQFYEMKKKNRHLKLIMSIGGWGTCHLFESVVSNDTKFDNFVNSTIEFAEKYGFDGVDIDWEYPKNSTQAAKLVELLARLRNKLNSKYIITVAAPGGSDNIEILKIQEMDKYLTFWNLMCYDFAGEGWSSKTAFHSNLFGNNGDNSLNASDVVQTYINKGVHPTKLILGMPMYGRIFHGVDRPEIGIPFTKERKSGCIEADVVDYNKFGDTFDYEDFDPRKVGALKYDSHSKQLITFDNLQCARIKASFIQSRQLGGGMWWDSAGDVSVTNDGCLVKNFVDQLGGVEVLEKSANNLHGC
The following text describes a protein:
Function:
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MSSIPTPPDANGNPLIALAVAVIYAILYVLQGVKYGVSLLTIGIPSCIVRMLQYSLTISLGFPHLLALFAGALLALFFLIRYRYLTRYAQLKESALPPPSPPALASRLLPLDGDGLGLPDSRSQTSSFHNYLDDFLSAIRIFGYLEKPVFHELSRHLQTRRLAAGDTLEIGGGEFWCVVEGKVQVFAPDASSQGTPTPSSDTNSPTRPSFNGYHLLNEVSTGGTLSSLFSILSLFTEDIKLSWKSSADDEGEEEQIFEGAPEQSSAKLRVRRANSDVSQLGPDSIGVRAMDPTPLPESIDSHGDSSVPQRRRERSSSIDAAGETVREREGIFASASLPISSTEPPSPRRSQSLRSSPRLNSATNLLSSQSEHLRSSVPRKAGIEIGSKALKGTIARATEDTTLAVIPAAAFRKLTRKFPKASGTIVQVVLERFSRVTFMTAHKYLGLTREILQTESSLNLLVTHPLPRSFYTGGGMQALRARFQPEALAKESVHYDSLKSSPNARVSSKDYFNYVPASPTVKAPSLPAMTPKPLSPIIHKSSLGQTATTTVKNEPLNGGSSPLDETRDKVPSFGLSTAAATNPDASFRHASPFIRRTSAMRQQVAAGDLAMSVHNLPDESGQAYYRPTAITPGLSKMDTWQRRYSSSWNLNDSPHTDGQPVDPQRDDESLLNESFDLKEAVLNSIAKSIGLYQEAESNSDMIARSSMAPSVSALSTPNSPMFPPNAGTPLQGSTRSRPPHFGNVLDLINASSQNEGVIGGMLREAAFNSRPDDEASSISMSLHDSQGGASGVDRKIMKDLERHVEILFFKKGSVLVKEGERSPGMYYVIDGFLETSLPFRSTSSNQENPNSTPGSKHRQSSFGSSNERPFKTALGLDTSKGKELDDGSKKDEALFTVKPGGIAGYLSSLCCTDSYVDITAKTDCFVGFLPHHTLERIIERRPIVLLTLAKRLLSLLSPLVLHIDAALDWQQLNAGQVLYEKGDKSTDFYIVINGRLRAFTEKNDNMHVLREYGQNDSIGELDVITAVDRSETVHAIRDSELVRIPAALFDAISIKHPETTVQFMRLIAGRVRRALGDEMNGRVPGLPTTDMNLKTVCVLGSTRNVPVTQFAGKLKNALEEIGASTSYLDQGIVMRHLGRHAFARIGKLKVAGWLADQEQHYRTVLYVADSPPASQWTLTCIRQADLVLVVSMGDDPSLGEYEKLLLATKTTARKELILLHDERTVAPGSTRQWLSNRPWIQTHYHVELPGVVTPARPIPPVHDAAAIAAFKHLREQVETRIKKYRGLRPFTRPRRPPHMNDFARIARRLCGQQIGLVLGGGGARGISHIGMLQALEEFGIPIDAIGGCSIGSFVGGLYARETDLLETAGRTKQFSGRMGSMWRILSDVTYPFVSYTTGHEFNRGIYKAFYNTHIEDFWIPFFANSTNITHSRMEVHRTGYAWRYVRASMTLAGLLPPLSDNGNLLVDGGYMDNTPIQPLRENGIRDIIVVDVGSVDDTSPRDYGDSVSGWWIFFNRFNPFYERRVLSMTEISSRLTYVSSVKTLEGVKATPGCHYIAMPVQQFDTLGGFKRFSEVMEIGLKAGRETLKKWKEEGKLPTGLVDEAKGSKAVQRGNRLRRMSI
The following text describes a protein:
Function:
Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MPRRRGGGGGGLRQAPAAFVPLASPSYYERVGQLQQALRDSEKKRLDLEDKLYEYNKSDKCRAKLKCAKLKKYLKEVCESERRAQVRNQGYLKKFECVQSLVEHLTTNTEKLQKLKDAMQAGINSGTAMSRGLYQPATIFMGRQMSAISSIEDFSTEQKSNQPTKNFSISDPHSHQQTAQSSCVTDSCVVQTNGDTQCLNKSDKIHGKTSLQTGEKTPVTSCVLSEEEQTHCLEIGSTTRHSKSNLSEGRKSAELHSLLQERLSPENRITDLKYDSSSRSEGSDREILTQEHIEVEEERANPLVPMISVSEHCISANKWTGEKLSAWEAFSDDLDHGDPKSQKSFLKIQEEQEEDSSCSSSDLTVSVSEDDLILENLEALLNPGAKMAGKDVMQASPSVRTEPRQDSIFTEYVLQTQSFPDSKREPSPDSARQAEAVPGCHLLKTQGQCTKEHDDSLKEATTLLKKVLTEECDHRSAIHSNESSCSMPSILNDNNGIKEAKPALRLNSVLTREQEVSSGCGDESKEEGTAAVPVTGGYGTEGHREADLVPSELFPFSLGAAMKETKAYQLLKKSTLQDNSNQAEERFESQFSSLDIGGSTFKTKTAHKIASEASFSSSEGSPLSRHESKRDPVTTIKSNAFWGESDDSNSEIEAALRPRDHDTPDDFDDFYDT
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MEGGGGFGGCHDMISLLENSNNTSLWHPSSSAHHANVMNFDHEPQLGRIANPKMNICDGILGRRTDAEDAGGENSKNSEKKRRLTVQQANFLEESFELDNRLEPERKENLAKQSGLQPRQVAVWFQNRRARYKTKQIEKEFDSLKANHDNLMVDNKALKIHNDSLHKENDNLKIELEVLRKKLAQYEENEIYLDPDNITQTYEPPTNMVTGQDGVVLQGMKQVEGASSGKSDVFDYESPHCVDGNQSTAPLENCSTLIRDPDDNLSDFAQDEHLMMTRTLLLPQTPPTFNNFLNVAADDDNSNNYNYDPNAANSNNLSLGFDQTFWSWG
The following text describes a protein:
Function:
Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence:
MLWKSLIALCVIGAAVAEQTPVFLWGANSVAKPSLKTVSQVEFAEQLAALLEDHMVVAFEENGLSSKDFLCSNSQAQSCYAQLQGVSPKTYYTSVENPSEALRSVAAKREHNSIDASGKLTTPAKCAVGTALFVTFEDAAESREASLESHDAAIAAISKQFECKVAYLYLAAPSTAPVVQRRTRRDTAATTGGIMWKSTNQFQIFYTALLYNGNPITVTDLKLTNSSSTKLSVVMDTSVADKPITFDVVYNGGYFSLSNLVYDNNNFRSSGVNAPTTFSYSCGNLTLESAAVNNMYNTLSFKSLQLQAPFDGTYKEDFPFGDSWDCVGFVTPGILMGLFVVALLLVIMFVGVCWMMDINTMDRFDDPKGKTITINAAAE
The following text describes a protein:
Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.
Sequence:
MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR
The following text describes a protein:
Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.
Sequence:
MANNRYVAHTIDYCMRGMAMLGVLVMEFWPRVTASPMDFEADPELVFGEEFCFPATAYYPTPYAPAGTNLPAELYEPQEIWDQYLQYSGQQAEGSSCSYYVVPDYGITHSPIGPYPSEPSVIADGRFVGAQGYLASTTDSTYHQPVPTTPYDAHPFAAQWGPATTSQTLTYTDSLFIPSGQDQSIPVAPNKNITWNPSAQSTSVSSKKFQRNAMLPKVQLHSSDPWKQDPATRTMVPAKLRHIPQASRQYLQGGVPSVTSSPQTNPSCNSNASYDGSDLRKMAVAEKFKPSSKPRSCLYGSTGRLSCQNLGNGKTAIGSSEIVVKSYTSSLHIGDPEGKIIIRPDQFNRNDFQVVYPNAKFFVIKSWGEANVHKSVKYGVWSSSIQGNKKLDRAFGDAQLIAASSSTTCPVFLFFSVNQSNHFCGVAEMVGPVDFRKNMDFWSQDRWVGSFPVRWHIIKNIPNVALQYILLQNNEYRPVTFSRDTQEIHYGPGTSMLKIFKATRVNECLLDDFTVYEEEEARSIKCTTSKLRGDAPRFIPFPKLYGRGACVPRQPKADKVLVDRIIRESHNLADRLRHVNLDMHQGSWEKPGNLIRDCATTYAQKDIHCYGIQAPENVVKAVEFQPLASNMLAAFDGELTREKVQITPLGKEYPRTVAKVSPKAPEEYQTEDKITLVHSASAAPDTIYQEKKIIREQCSHPIKSQVSEACSRCSIDDVIRIGSMLLPMKMSS
The following text describes a protein:
Function:
In blood stage parasites, phosphorylates translation factor eIF2alpha in response to amino acid starvation. During the asexual blood stage, involved in the response to the host hormone melatonin which is used by the parasite to modulate its cell cycle.
Sequence:
MTSEDKTALCAENILNDIYILTINRNIDIDIIQEGLLRKVMDEEESNSILFLEDSSFSKNDISILNVHLKIEDGKNKYNNYYEFKYADINVTIDFYQKECKYSIEKSNMHKCHYFKMMNKINYITEQKMDFKDSILYLYNTINDKNFFKCPCWLNDNKNIKLNNIINDHQQKKKKKNLYDKSVQVTNDVTNIMVNEIQEQKMKKPIFFDNKNDLNNSDDEFNSAHSSLIKINKLLNVEENDIFHNLKGHVYEEYFDKHEDNKNQKDNIESNIIVKDKKDRANNIISEQMKEDYIKNVEEVLSKHINNNKNNNVEDSVSLYSLDEEISEQIDKQHFFSIDKRQDEISNFIQMEENINDHMNDNINKMGKKKHGKENRVVEDEKYIQDDKKKKRFYRNVNDNIPLTVQLANKGNEICKEIIEMNSRYYRDFFEEKILGCGGFGYVMKVKNKKFNITYALKIIRLSNSKYNTQTNNKHINEKDNNSYIMEEAIMIAKLQHENIVRYYDAWVEENVDFFLYKELQNEFKNIKIKIKNEKMKNEKMKNEKIISGKIKNENIKSENIKSENIKSENIKSENIKSEKVKNLYIEEIKYFWNHYKKNKDPNVNDKYLYILMEYCPGKTLREAIDCGFICRNEKLIWELIKQILKGISYIHDMKIMHRDIKPSNIFLQITDNILIAKIGDFGLTTRIGDTQINPSAGTIHYISPEQLNGEPFNEKADIFSLGVVFFEMFHEPFSTSMERSITLSNLLKGIYPEYMKADNKKFQFLSSLLAINPQERCCAYNLLHESVLFTFEKDFTDIYNLIDNKRNCEEVHTIISTLFDKFEYLNSDKILKKEDFSTFQNAKIFTDDLEMRKKQKIIKKKILISLKKRGAIFILTPIILLNKYYINLENTYMEEYNIYYNINKKKENKINNIYINTNKNKNIDNLIYMLDIYGNSITLRNSFFLSFAEYIYESIDSYNKYNEDNLFYKFYTYGYTYKNQIIKSNKHIKKDTINNNINTTINITTTTCNTTTGTSTNNNNNNNNNNMGNNNIGNNMGNNVSNIISNNNINNHMISNNPFYFYNIYPDENEKMFYCILSSSKNVFGNEELNYLSIFSNADIMVSIYTLYNHINYFNKLLFVWSYIDLLEIILKECLDIPNDISYHLSIDLKKNSTLLVNKSFVMSLLQKYKIKDMSKISDHILSLFYIKCESNKVDDYLNNIYNFVDDLLNKKSSLQLKRNTSITPKEVPYVRSRSNNISTSASKIIKYDIQKNVGTKEKGNQNDNEKKKMQIYSILDRIKKINNFICTNTVINNTCFDLFLNYEESIFCNEVIFYVICESKNKEIIAYGGRFDEIIRNMANEVKYKNHANYKYVYNNIKDIYNNNNNNNNNDNNIMNIKAYGVEIYLDKIYSKVIESNEKISIHLQYNPSTDKSQLFKNFVTSCQQNDFACTSHIIQQPLLNDDYLNYSSTKILIQVYEISNLLIAYDLSKKLLTKNISSYTHLSINNVNIKKKIKNFKPHKIQFFITIKSNNTDNSFDALKPINFDNVVYKIVNYDDQDCNFMDQAELINYLIKYF
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MKRLSNSDSMCGLISNSTDEQNPRGYGHNFHSMLNGYEEDGTTVEEYSGNHHMGQSEKKRRLRVDQVKALEKNFELENKIEPERKTQLAQELGLEPRQVAVWFQNRRARWETKQLEKDYGLLKSQYDSLRHNFDSLRRDNDSLVLKISELKAKINGEEDNNNNSKVTAESDISAVKEENVPSSPPEFIEHSTGFDYRRSFTDLCDLLPNSTALDGGSSDSCDSSAETSSENGRLTPPPTVTGGNFLQFVKTEQMEDHDDFLSGEEACCFFSDEQPPSLHWYSASDH
The following text describes a protein:
Function:
Transcription factor. Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C. Positively modulates transcription of KDM5C. Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. Required for normal brain development. Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain. May also be involved in axonal guidance in the floor plate.
Subcellular Localization:
Nucleus.
Sequence:
MASAALGAEPAAPGAAPPLHLLTSYFLDGLLGRSAQPGGSGGCGKGRRGGPRTGRPLAGKLAGGGGGRSPAPPQPPLTNPGEPPGPRRPGAEEEEQDREEEEEEEEEERSGGRRRRRGPLGAAAEPPGPAKRKQRRYRTTFSNLQLEELEQAFRKSHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKTEILGNVPGISLTHPLSLYLDVPLSSSALLDPVWRSLPLSTMPLPPVTPAFSPATLGPFGLSNLTWTSLFRNPILSPHFGRFLNALNPLVTTASVLMKAPGPPSDPTLTAFSDPAAVERKTSSIAALRLKAKEHSAQIPQLNLISSLTNTDKELG
The following text describes a protein:
Function:
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Sequence:
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAAETGRQTE