lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in maintenance of polarized growth and daughter-cell-specific transcription.
Subcellular Localization:
Cytoplasm. Bud. Bud neck. Bud tip.
Sequence:
MRSFIKSHRKSNSLESDSDIDFKQLKRKNASTSQLSPPRYNTDYYDPVTSSPKTPTHSHTTSDSLPQKHSPGFESLHRLFNNKLFKKASNSSLNSYLANTDSQSRRSSKDQDPLAPSFHVLKTSSNPASQDSELPVIKGVITHTWGNHSKHNDPHVIVLNDPKTSFETLRSSDLEPPPRLTSKTTRSSVSSERSWSTRDHSMSPPLTSINQDIDIPEDMATRSKNTLINKKKMENRQARIHSNDDLIAMRKNSSDTLPQTAEFFASDKLPGDSTPILEIPESPPPVITLEKYNSSLSDAKELSRSKNVRSNRTSVVSMTQSEESRWSNHLMVNSNHNQNKLRDSDDSDYSNAIDEEDDDDADDDDEASQFSFEYSNLSGRTPSVKYYSKPEPKQMVYIDDLYDDEDFDEDMNYYDENEVSEFLQEEMASNKNNINTDTSVLKDLSSPSINDHSNEKPIYKPTIQMRVNKPKVHRYNDLFALSDEDDPSFNDDDEFDEDEEEGGDDNDEEDEIDEEYDQKVSDECGQSIELQSDDIHSDYGVEYYNDFGGDLNLQNDVQKHHINKEQQYISDEEFDDAITDFNMAKHIIEEEVVLDKAEALRYQKDAEPVQSKTSEDVVNYVDEDSNLRINEKLEKGDVTYQKPTLLTEVKNKQFQKKPVASFADIFNLESDSEEDINNEDGLTGLSDVGLDEDDAVSSPILQSPFESQSLAEGLVSPVICTPGKPNIINKQIIPTIKCEPSSPQEKTIENNKSHTASNFKEYGLNHPLPPPARSQALKFHDLNSELDSELPALMSNLYFIDETEEDAYNELNDVTRDEDEYLDEINTVPEDFNFSDTENDNNAAKRMLRRSNKGSFRSTYSFTDKPQGVTTESSPIKNKLEVNNKTVTFFSSPGWSKSPGSEIGMQRSKSPVKPSSGYRPFGQGSKQFPITPSHEPNYSIEEDRIASTDEILESRTPPTTYMAPSPAFIPNYSLSPIQEASSSVTNSPKR
The following text describes a protein:
Function:
Self-assembles to form an icosahedral capsid with a T=7 symmetry.
Subcellular Localization:
Virion. Note=Forms the capsid icosahedric shell.
Domain:
The insertion domain (I domain) plays an important role in the folding of the capsid protein by acting as an intramolecular chaperone.
Sequence:
MALNEGQIVTLAVDEIIETISAITPMAQKAKKYTPPAASMQRSSNTIWMPVEQESPTQEGWDLTDKATGLLELNVAVNMGEPDNDFFQLRADDLRDETAYRRRIQSAARKLANNVELKVANMAAEMGSLVITSPDAIGTNTADAWNFVADAEEIMFSRELNRDMGTSYFFNPQDYKKAGYDLTKRDIFGRIPEEAYRDGTIQRQVAGFDDVLRSPKLPVLTKSTATGITVSGAQSFKPVAWQLDNDGNKVNVDNRFATVTLSATTGMKRGDKISFAGVKFLGQMAKNVLAQDATFSVVRVVDGTHVEITPKPVALDDVSLSPEQRAYANVNTSLADAMAVNILNVKDARTNVFWADDAIRIVSQPIPANHELFAGMKTTSFSIPDVGLNGIFATQGDISTLSGLCRIALWYGVNATRPEAIGVGLPGQTA
The following text describes a protein:
Function:
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
Sequence:
MQDEYYMARALKLAQRGRFTTHPNPNVGCVIVKDGEIVGEGYHQRAGEPHAEVHALRMAGEKAKGATAYVTLEPCSHHGRTPPCCDALIAAGVARVVASMQDPNPQVAGRGLYRLQQAGIDVSHGLMMSEAEQLNKGFLKRMRTGFPYIQLKLGASLDGRTAMASGESQWITSPQARRDVQLLRAQSHAILTSSATVLADDPALTVRWSELDEQTQALYPQQNLRQPIRIVIDSQNRVTPVHRIVQQPGETWFARTQEDSREWPETVRTLLIPEHKGHLDLVVLMMQLGKQQINSIWVEAGPTLAGALLQAGLVDELIVYIAPKLLGSDARGLCTLPGLEKLADAPQFKFKEIRHVGPDVCLHLVGA
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDILSSSLLPMKGTQHALLQALLSLPPGLALGPTLTQGEGMGLWCVGKVLQCGTLLPPRSSDADGGSIEIMDHLSPNNTNHWLRYIRSSLNEQNVKLCTLSGAVHLQVITTIHPGSELHLHQEGHRFATENDGNPGQHQTDLRQGAQASERLESAPVPVDEQKRKLDSKDAEMLECNCPPTVPLPLIMSVVTPQPNGPSAAGTPETESTASAEPAEQENLNPIITEPEGAKLLISLHHINCSAEPATQQAVPVQYTQVTECLDTTDLRPVEQEKTLQTSQNKNTHVASVAQSEASHEQHKPEGIQEHQKPSKVKLPKEKPKEPGGEAKSAVNVKKARKAPKWKSAASNRRKGAKNTDTSEDARCEPAEQKESPNALLVNKKCKIQPQTERRFPCKDCDRSFFQLGHLKKHSFIHSGLKPFLCTDCGKAYSSEESFKGHLLSHMGLRPFKCQLCDKAYSTQRDLREHAVLHTGQRPYRCEDCGKSFTRRPTLRIHRKNYCTSAASIDYKPSLECPVCRKMLANSCSLRNHMRIHSGDKPFTCSDCGAAFRHKSSLRVHKRLHTGEKPYKCQYCGDAFPQQPELRRHLIMHTGEMYLCTVCGKALKDPHTLKAHERLHTGERPFTCQYCEKSYPLATKLRRHLKSHLEEKPFRCHLCGMGYSSQPSLKRHLRSHKEVAETGYSAATANENLETESTVVFVQVMDSEESPSQGEVLVAEYTDNPEPGLSQNPPAVLLPMHSGIVAVSSEPGQGKGILLQKDNGHVVLLVPQALGFSAVAEEVEVESGT
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Miscellaneous:
MISCELLANEOUS: Present with 8450 molecules/cell in log phase SD medium.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MQFFKTLAALVSCISFVLAYVAQDVHVSFPSTAGKSRVMIGKVEPRIGIDETVPTTITVEDPNEVIQVNFAIESTNKPFQNTLLIGLPNKNLEMAFEPEIKDNGKLSMYKYRIDLAKLDAALLQEASRSPEPIKATLILASSTAKPKENLFREILQLNLNFDVDHSDSSLVDKFGIKPEIHHIFHAEPKRVAKPIAVIFVLIIFITILSLIVTWLNSCAAAFNNIPTGVTAVYFLGFIATIVGFEVIFARYYLGTSIFETLFSSLYLGAPGLLTSTKFLRSFGQTI
The following text describes a protein:
Function:
RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).
Subcellular Localization:
Cytoplasm. Rough endoplasmic reticulum. Cytoplasm, P-body. Cytoplasm, Stress granule. Nucleus, nucleolus. Note=Predominantly cytoplasmic. In the cytoplasm, localizes to peri-endoplasmic reticulum regions and may be bound to the cytosolic surface of rough endoplasmic reticulum (ER) on which ER-associated mRNAs are translated. Shuttle from the nucleus to the cytoplasm requires RNA-binding.
Domain:
The CCHC zinc fingers interact with the GGAG motif at the 3' end of let-7 miRNAs precursors, more generally they bind the 5'-NGNNG-3' consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5' end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members (By similarity).
Sequence:
MGSVSNQEITEGLPKSLDGTADIHKSDKSVIFQGSGVCKWFNVRMGFGFLTMTKKEGTDLETPLDVFVHQSKLHMEGFRSLKEGESVEFTFKKSSKGLESTQVTGPGGAPCIGSERRPKVKGQQKRRQRGDRCYNCGGLDHHAKECKLPPQPKKCHFCQNPNHMVAQCPEKAMQAANLEDQPITEEQELIPEIME
The following text describes a protein:
Function:
The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Sequence:
MNCLATTIIITCKPTLISDMAVAIDPFSDKFPYFNRSSQRCRLQSLTNLDFNFLAQSFNHTFEDDNIHRSVSSPCFSIAASANMEEDLKATTAPRIEILGGQRVPTVRALVAEVTMAMVSGAQPLLLPSGMGGAYLLQTGKGHNIAVAKPVDEEPLAFNNPKKSGNLMLGQPGMKHSIPVGETGIRELAAYLLDYQGFSGVPPTALVSISHVPFHVSDAFSFSSMPYKVASLQRFVGHDFDAGELGPGSFTATSVHRIGILDVRLLNLDRHAGNMLVKRCDKKEAYNRLGTAELVPIDHGLCLPECLDDPYFEWLNWPQALVPFSDTELDYISNLDPFKDAELLRTELHSLPESAIRVLVVCTVFLKQAAAAGLCLAEIGEKMTRDFSKGEESFSLLETLCTKAKASVFGKTSEDSDYSHEGNEVNTELQCGMFKFDGGDTPCEAEISEVFHVSKPPLVPRGPRANTIPNDVTASMSSSQNQRITHQEKSAKEKKRGGKQERCTVRSKSPPISPNHDESKGVSFVDMTTVEWDTFLQSFQTLLQDALSKGSTPRLGCSCEI
The following text describes a protein:
Function:
Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
GRYEGERNNDGERHGYGTALLTSGDTYQGLYNNGKRHGYGIYRFVNKARYEGEYVNNKREGTGTMYFPDGSMYKGEWKNNKRSGNGKYKYANGDTYEGEWKLGRRHGQGVYVYKDLGISYKGNWAFGKFDGKGQVHTPYYVYNGTFYDETPRGPGRFSFKTGCAQTGQY
The following text describes a protein:
Function:
Plays an important role in the biosynthesis of the phospholipid phosphatidylcholine. Catalyzes the formation of CDP-choline.
Sequence:
MEEPKPKDVKDAIVSYSNGRSDDTAPDRPPRVYADGIYDLFHFGHARSLEQAKKLFPNTYLLVGCCNDEITHTYKGKTVMTADERYESLRHCKWVDEVIPNAPWVITQEFLDKHNIDFVAHDALPYADASGAGKDVYEFVKAAGKFKETKRTDGISTSDIIMRIVKDYNQYVMRNLDRGYSRKELGVSYVKEKRLRVNMKLKKLQEKVKEQQEKVGETIQTVKMHRNEWVENADRWVAGFLEMFEEGCHKMGTAIRDRIQERLLGPQSRESTYFLENGNENVEDDDHEEYYDEDDDDDYDEEDYYYYDDQGSIDEKEKH
The following text describes a protein:
Function:
Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPDAKKQGRSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQSGWALFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIGIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEHIERNLMKGRKLREIGAHD
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Involved in salt tolerance by modulating sodium transport activity and repressing cell death at least partially through modulating SHM1 stability and activity. Involved in cadmium tolerance by interacting with HIPP27 and probably modulating its stability.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MLLVLDLGISSLVLVVSLVLPLIGLFVRHKWRVAAQRREEIRRLLIHASEEAARAELEASVEFSSVAVSNVFHCPVCYCLATTRCSRCKAVRYCSGKCQIIHWRQGHKDECHPASIVYDSEDESDSDLRLGEENGQNTPEETLLVGPEPVTIPIGESLLSNRARSPEDGNGDIADNKDDLIDKEEAVSVAETSGSSFSGFSSSPRNDSGDEISRCESFSSSESERSESLLDAHVSVEPEDTCFSTIEDAPSKLLSPKFVHLVESVDNLANLPKLSVHKPEDDAGQNQSQSRSLHSLVTDRHPVSADPSLKSSDFWGTALGSAERVSDSCVKSKSGRPGNSSLHFSFGSGSSRDTSAAKVSEQRSSILKEAPRGTGYISDGVNLRERNAKRFDEAEIALPISSSTDALSPLDSSNLSHVTLPKSKSASSENGSMLAPLKVGEVQLLASKASNTKKCADLMKHSPLGAKSVRVLDHQKQNGAVVQHINSLHGRSGLKASVLKVVDQWTRPKSENEMAGRHGHKGLFPYEVFAKLYTYKIEFQPCGLINVGNSCFANVVFQCLMFTPPLTTYFLQQFHSRACTKKEQCFTCGFEKLVVKAKEEKSPLSPNGLLSQLQNIGIFLGNGKEEDAHEFLRFVVDTMQSVCIKASEYDMTKSSKLEDTTLIGLTFGGYLRSKIKCMKCQVKSELREKMMDLTVEIDGDISTLDDALRRFTRTEILDGENKYRCGSCKSYERAKKKLKITEPPNVLTIALKRFQAGKFGKLNKLIRFPETLDLAPYVSGGSEKSHDYKLYGVIVHLDVMNAAFSGHYVCYIRNQNKWYKADDSTVVTSDVERILTKGAYMLFYARCTPTPPRLAVCTKTEASNKKSRVPLPKANEKSTISRSVSTSSPELSSNTPGGGRSGNIQSFYSSFQRLQKILEEDSASDSSSLFDSNSDECSCSTDSTSMDDFADFIFGDHQGRAHGQSETPSPTSSSSSSSPPFTRRSPLSRSSPETYGTSRHQLPLGGER
The following text describes a protein:
Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation.
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDEDIQ
The following text describes a protein:
Function:
Transcription factor (By similarity). Involved in specifying AVH neuron identity, acting in concert with unc-42. Involved in serotonin-mediated feeding behavior, probably acting by modulating expression of genes involved in glutamate signaling.
Subcellular Localization:
Nucleus.
Sequence:
METNLSEEKQKPSKSQAQQRRQMENYEFSQLANELPLARAISGQHIDKTTMVRLATAYIKLHNIFGQSQRAYSSADYYYGSDSLWTNNHLDLLDGFFVILDRRGDVLYISETISIYLGLSQVEMTGNAMVDYIHEQDINCFNSALNYCDLNWPQMCNVRVKSSLTKRANKDAVRASPGYKVLRLEITMGPNTNTRMIACYPMPTPVLSTVTIPSNSFVIITSIDLHITFADEKAHQLLNNPFYPDSNIKGMSLYSLIDISDSEVISKMHFDIFNLGAYKTPYYRMILNQTSETFYVESNIFRHTSISSKQFNDSITFVSSIL
The following text describes a protein:
Function:
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RpS23), thereby regulating protein translation termination efficiency.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Localizes predominantly to the nucleus. Present at lower levels are also detected in the cytoplasm.
Sequence:
METSSSSPVKPRRKDKDEDGRAEQEDSADQVGEPHRKLLRLGDILETNEVLLNEAYQQPELTKWLQTAWTEEKSQGTKETQTGAQVFSDPFQICLLPGMLEKGQSQALVAEIIQKVQWSRKQMDLYEFYQSADLSNMPACRLLTNFLQVLRKQVRPWLEKVTNLKLDYVSASCSMYTCGDYLLVHDDLLKDRQVAFIYYLSPWEGAEEWTDEQGGCLEIFGSDDQCFPQFPVQRKIAPKDNQFAFFKVGSRSFHQVGEVTTFDYPRLTINGWFHGDTNEAFVADSLRAFPRLNYLQPDGLNRPPLGLFLNNVYLKGATRRSIQKRIEENSEICLYEFFKREKFELARSQLLADSDTLKWRRQGPANAHNYEVLDLTTARGTILELLQLFRSHAMFDLLRDFTDLDLAGTDAESPTCSVELQRWSHGNYTVLGDGLTSEENTLDLVYYLNAAEGAAVITYLAPDAEMPTAKAPTDGRRSDYDDEEEDDSVLLTITPVDNALNIVYRCEGTTKFTKYVSRNTPLEKGPVFVISCSYKE
The following text describes a protein:
Function:
Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis. Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Sequence:
MAAAAGMMLLGLLQVLGQAMEEVTGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLTAGAKSPPYIFSPIPFLGHAIAFGKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAAALLFNSKNEVLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKKHVSIIEKETKEYFESWGESGEKNVFAALSELIILTASHYLHGKEIRSQPNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYEDGRPLTDDEVAGMLIGLLLMGFFLARDKTLHEKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRHPVMIMMRMARIPKTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDPSREKFAYVPFGAGHHGCIGENFAYVQIKTIWSTMLRLYEFDLIDGFFPTVNYTTMIHTPENPVIHYKRRSK
The following text describes a protein:
Function:
Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). Plays a role in regulating Rho-mediated dorsal closure during embryogenesis.
Subcellular Localization:
Cytoplasm. Nucleus. Membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction.
Sequence:
MSDSYYQGEYIKHPVLYELSHKYGFTENLPESCMSIRLEEIKEAIRREIRKELKIKEGAEKLREVAKDRRSLSDVAVLVKKSKSKLAELKSELQELESQILLTSANTAVNSNGQESITACIDPNGGFLVSGAVGGLGGGNTALEGGAPATANDKVLASLEKQLQIEMKVKTGAENMIQSLGIGCDKKLLAEAHQMLADSKAKIEFLRLRIIKVKQNREQADRLKASRQMIDEHGQTIGGNNSSQPQSLETTLEERIEELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQELPADSPAAQQLKTELQIVQLSTSPAPVTYTSLQSGQAGILGGKPYQSVSSLGRCASVTGKLEVRLLGCQDLLEDVPGRSRRDKDNNSSPGDLRSFVKGVTSRSSSKSYSVKDETSIEIMAVIKLDNITVGQTSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEPQGLLFAEVKFLNPMISQKPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNAPNHVHMGSAGSGSSLTGSSPMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDPAASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAPTTAPPPPPVLKATSTTPILDQEVIPQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTAEWC
The following text describes a protein:
Function:
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.
Subcellular Localization:
Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Partly associated with membranes.
Sequence:
MEEPPLLPGETIKDMAKDVTYICPFTGAIRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLEIVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKVYDPIWEYRRQGIPNESWRLSKINEHYELCDTYPAILAVPVNIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSLLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCSSEQQRVKESLPKKTVSLWSYINSQLEDFTNPLYVSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPVHNRYKELLAKRAELQKKVEELQREITNRSTSSSERAGSPAQCVTPVQTVV
The following text describes a protein:
Function:
When expressed in E.coli with Synechocystis PhaC and C.necator PhaA and PhaB, confers the ability to synthesize up to 13% (w/w) poly(3-hydroxybutyrate) (PHB) depending on the carbon source; all 4 genes are necessary for PHB production. Cell-free in vitro coexpression with PhaE gives a heterodimer able to polymerize 3-hydroxybutyrate-CoA. This subunit has no catalytic activity but enhances the activity of PhaC, the catalytic subunit (By similarity).
Miscellaneous:
MISCELLANEOUS: Nitrogen-free medium induces chlorosis in Synechocystis, leading to the degradation of the photosynthetic apparatus and concomitant accumulation of cytoplasmic polyhydroxyalkanoic acid (PHA) granules which in this cyanobacterium are composed of PHB.
Subcellular Localization:
Cytoplasm.
Sequence:
MESTNKTWTELMTPLSQFWLESSSQAWKNWFDLMAKGGAGAMMGSAPQSFESLPQQFLQSQQFYGELLKLSFEAWQSLWPKLDNGSAPGAVQGYLKQLQTQIEQYTATTQALQGDMDGLWQCYIKEVQRFSQLWLSTWQSSVAPLGKLPTGDIHAWLDLNNLYGDALYNKNLSSFMRSPLLGPSREMNGKLLRAFDDWVKLSQAMADYQLLEADIQYRGFAALMEDLLARAKEDKPVKTWKEFQQRWAIAADQVFEEAFCEEKNLKVRGKFINALNRYRIQQQEILEAWLKMLNLPTRSEVDEIHQTIYQLRKEVKSLKKRLGETEANPG
The following text describes a protein:
Function:
Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSINEVFRSFKAQPVNQLAKIQAERPIWFVMVGAAIFLILSAIFYFQLFLAMAPCEKCVYIRFSQSCIVIAGLIILINPRNNILKTLGLLLAWYAMIQGWIWSFELMKIHDAAHMVVDESMDFFAAAGDAAGSACSTEPRFPLGLPLDKWLPFEFAPTGGCGEDDWALFGLNMAHYCMIAYATFMVCLAPLTLGWFASFMTDRRNTIVYQTR
The following text describes a protein:
Function:
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB.
Subcellular Localization:
Nucleus.
Sequence:
MVTSAASMSDMYNLDSQCVTPPCNMSWAMEPANFYDNKGDAKPGENNNNNSSSTGNMMELSNAPAIYDDESAIDFSAYIESMSTVPLEICNDELFADLFNNTVKQEKPDFYMSNTFAHKSAERHLEGFGKGSFCAPIKKEADWSDSEHSSSLPSQIEACAQTSVNFMHTGQPTPPTTPEPEPVAHRRPGKEKGKKNVDRHSPEYRQRRERNNIAVRKSRDKAKQRNLDMQQKMIELGAENERLHKTIDQLTRELSSLRNFFKQMPEASFGSAARAAVDSR
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MGEMEVENQVLMKMRFSDLNPPLSKPVLDDLDSGGFQFCTPVQANSIPLLCSNMDVAVDAATESGKTLAFVLLLVEILRRASHRPKRNQVMGIIISPTRELSSQIYHVAAPFFSTLPNYKSILLVGGFDVRMDLRKIEEEGANILVCTPGRLYDITERIEILNFKTLKVLILDEADRLLDMGFEKKINSIITRLPTQRRTGLFSATQTEVVNELARAKMRNPKKVQVLTSYKTPSTLHIQYCKCEADKKSSQLMDFLKKNTYFMTRACVDYWRFVIPKLSILENCPLIQLHGKMKQYDAPKDPKDFVHRVGRTARMGRPGKALIFLYPKEYPYVEFQKIRGIPLNKMECPNDVLDVVPLIRNVAKDCRDTMEKGLTAWQELEFGKLAMGYGLLQIPSISEVKHKSMGFIPVEDIDFSEIKYRDKSREKQIQKEMAMVDANPKPKKVKNPPSSVVLIPRRKTGHQRRIIQTKEDNEELELEYRLLKKLKRGVIDENEYDKLTGLTQPETDIQKNCTKTAPSSWVGKNKARSKDNGNKRKINGSAYKKHKKRKI
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MDILQQSGFEEVNKRCVDCNTTRTPLWRGGPAGPRSLCNACGIRHRKKKRALLGLDRDSRTEKSKSKTGTDVSRSGVKTLGREMGLHRMVGKQEWKSKLREEEQAAFLLMALSCGPAHA
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MASVIVNVRPGLKLFQSVLTCSSRRAFGSTSVLMNEDPLKLAQLKDAPLKSLNDLLSSSEKNDGLITVENKVDISSLTGVPQEHITTRHVRIWKPVKHAMQSGTNNTHKWKMEFESRERWENPLMGWASSGDPLSNMQLSFGNKEEAIAFCEKNGWDYSVNEVVEKQPRPKSYGINFSWNKKTRTSTK
The following text describes a protein:
Function:
Required for TORC1 to properly control gene expression and chronological life span. Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.
Sequence:
MSNENLSPNSSNPDLTKLNNGESGTIDTSKFSPNEMKLYKMYGKLPSKKDIFKHTMQKRKYFDSGDYALQKAGIQNNDPINYGKNNLPLTNPSKLREDIIKRRISTCPSTASTAGVVDNATLIQKEGSISSGPPSSNNGTIGGGSTSSTPVGNHSSSSSSLYTESPIR
The following text describes a protein:
Function:
Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.
Subcellular Localization:
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Sequence:
MCGPRNAEAVSWRSWLIEVCGFALAALTLVLTLIFASLPEMGFPCFYATVADYDTLNDTSGGVWTRQPLVAPALFLETPTVTSFFGFTATVLLAHALYAVAGAVVLRREAGRLAFQPSVVLYAASTVAAPGTLMLGALCAWTLQAVVLLMAHKQAGLAAAAYITHFVFLALFGACHACKGTGDVRAALAASPPLRRVAVHARAVVTNVVLGAVGLGAAVVGLMLGVLLANSFHISLWKTAEAALAVFTLLALALMVFVEVVVSGYVQVLPTPAFCVLVASAAFGVSAHRYFAKFSEALGETHGVVIGTRAVLAVLSLIALAMIVVRLVRACIAHRARGSRFYANVDKARTTARRYLQKRLHGRGNDEYLLAPGSGDDEFDDGDEVVYENLGFE
The following text describes a protein:
Function:
Acts as an anti-FlhC(2)FlhD(4) factor by binding to FlhD, decreasing its ability to bind DNA, and thus negatively regulates expression of flagellar class II operons, decreasing motility in nutrient-poor medium. Required for resistance to host phagocyte oxidase. Suppresses killing of macrophages, while promoting resistance to hydrogen peroxide. Data regarding c-di-GMP is controversial; suppresses bacterial c-di-GMP levels but neither synthesizes nor degrades c-di-GMP.
Miscellaneous:
MISCELLANEOUS: The multicellular rdar morphotype is characterized by the expression of the adhesive extracellular matrix components cellulose and curli fimbriae.
Sequence:
MIASLDELYHSELFFLPVMDENARLVGLEIIATFAAEDGAVRMPTELVAPRLSVEEQYCLFVEKLALLETCQHFFIQHKLIAWLNLPPAISDLLLLDSELFSRAARFPFLELAINENYPGLNQGKNNETLANLAMHFPLMLANFGAGEASTKAIFDGLFKRVMLDKNFIQQRAEMISFEPFMHAIVAQISSSCESLMIAGIDTEAMFARAAPLGFSAFQGGLWPPVPVSQLIKLVQR