lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTSPAEVEGKELASLSPVDFIQLQQYIDYCGLKVKDVLKDFYGDKALAKHRNGEWIDEEGFQLFLKTYLEVDDLPANLSQRLFRSFQNSEKDGASDGSGQVCLKDVSCYLSLLEEGQPQDKLEFTFKLYDKDGNGLLDSSEVDRIIAQMMRAAEYLGWDVSELRPVLKDMMTAIDSDGNGTVSLKEWIEGGMNNVPLLVLLGLQMTQKDGQHLWRLKHFNKPVYCNVCQNMLLGLRKQGLCCTCCKYTVHDRCANKDVSPCARTYVKSKKDTTVKAHEWVCGNCDSSKCDKCQKKIKSYQGLTGQHCIWCHLKLHNECVSQMSLQCDCGPLRDHILPPWAIYPIIQEHSTLKNGAPSATSPDDNGLYHTTPDGQVLRISPIPDTHPLLVFVNPKSGGKQGERVLRKFQYLLNPKQVYNLSNGGPGLGLHFFRDLLDYRILVCGGDGTVGWILDAIDKANLLVRPPVAVLPLGTGNDLARCLRWGGGYDGMDLRRILKDLENSTQVLMDRWSVTVIPEDSREKGDPVPYEIINNYFSIGVDASIAHRFHMMREKYPQKFNSRMKNKLWYFEFATSETISASCKKLKECLTIECCGVPLDLSNRSLEGIAVLNIPSMHGGSNLWGEPKKSDGKASANQEPPPVITDPEVLKVSVQDLSDRRLEVVGLEGAIEMGQIYTGLKSAGHRLAKTSQITIRTKKALPMQIDGEPWMQPPCTIHITHKNQANMLMAPPPRSSSFFH
The following text describes a protein:
Function:
May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGIGAPRGRYGPPSRRSEYRVIVSGLPPSGSWQDLKDHMREAGDVCYADVFRDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSNSRSRSRSYSPRRSRGSPRYSPRHSRSRSRT
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MGQKHSISLNKHYTITDLLMDKRNVLDNRKYECSICLELLYNKQVFQCREGHYSWTDAITTSSKCPVCRVTVKSIEELSRNRFVEEEFAELQVVCPFLFSNILDITNIDERVLESDEKNGCKKIMKAGELEEHLKKCEHRYVNCLNSDCPVPVRSNETKQHAEHCDYSPLECIYCSNKFTTGSIEKHYLECQNIVLSCEQCCTKLKRSELSNHIDNECPNSIVFCKYKSTGCLGQFKRTNEATHLNEINHTVFMTKYICGLEKKLEESNVKNEEILKTLSSMLEQLKHNNSLLKKE
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSGRSNTIKDIRSRIKHENTSLGSGTAASTFSTARHQVPNVGEAFGNHPGSASFGGAPSAPNNAGALGAGPSFVSLAPSDSISNFEGRSSHGYSASTSQAYDANYNDASGGHHQYQYNAQRQQQQSTGVYARPTSPTHQSTASFAMEPTFSASSSNAGAAAAAASHGRKPSRQDAYDPSTPNSPLRPARSMRRPTQAPEVQRGLASISSSSTVRDRTREGPQRPQLQIPPVGSVSRSSASPSSPVRNSPGRDLLTASRSHGGSHLHNPSAQSTGSGGGPLGSHATPSSDRHTRSAQLMAQMARSGTPSSQPDSEDHEDLYGGLSPIDAPSDSHGASLYSNHTGFNVLSVPGQRPQRDPRRESGAPLGSLTEDNQPAALDSVLSALTSAGRKRQAARIMRGTTAEEESRRRRNEKEISQTSRQQRKPLSSYVDASDPRAFQSINAVLRKVQVEWPFVANDQFNSVALALSMLDESSLGASRFEFDQVKQMIETALQGTVDDHYESFASAITTHNSVLQSLTVAQTSVSGARRRLRDSREALGAKRADLVQMWQRSQAVKEALRLLDLVEHLKSVPDKLESLMAEKRFLESVNLLVRSLKMIDKPEVVEVGATNDLRAYLKGQEQAMLEILIEELHNHLYLKSYFCDARWKVYSAGQDELPVVKFGSDYRGISNPADADASTETGAPSKHSNEPLQLTQYLQSLRTRPTFDPNLASDIPESTLMISTKSVSALTGELSGGAASAAAAMDGGSTGSDISASRSGGRYGADFDQNPEADSFLYIEMLLESLSRLGKLGAALDIVSQRLAMEIHQLVDTTIDEVDARNEPLRRFSVALRPESVLLASSSALARSFTESMRTSCSSFNISKRPVSTMLRISAGETWALQRDGETMRDLFWTLFSKLDAVLQGHRVVYEVAGMIASRSGFKDEIASKKLSGVAALLQVWKPVQQEVRTLLHDYLMDDEGANSARNAVISVNDVLRDHRFGRDRAKPLFKLADAGVKRVAGRREMGLVQRHQVAVTQALKASVPGLVSSVDAAGMSGARAGSQIIVASSAVGTTMSSMASSAVTATGMGNAYRTGARKLDSYTGAGHRLLVKPDAFNVSVLFEPALVFVERVAAVMPREAAGETSRGFGTFLEEFVQDIFLPQLEDKVQTLFNSATLHADSFAADPASRQLTGTRAARAVVKSASNVIVLIDSLYSMLRMTPFHRESYSRLIVTLIVQFYQRCAERFRDLVSITDAERGASSGANRANEARYALSASWAQRPEMVACLAEMRESSTSDTRKAELLEQEARFQLGYAKASEPIGVYELTTSRKKLLAMGCLQHSVDWFATNIARLKAVEQANDVGAREKRARARLSVVDPLAFNAGPRFDLDPGATASSDEVDLDGEQLALPLTEDLVARYSAIGGVYHALSSSLLFTLRLELRLRIISLLHSSITESSYMINDTAIEPSPHIVELNSELANLDDIFTETLSPSDRLWIWSGLSGLIDACFITQVHTIRGVNRQGVGKMVRGILAVQQNLKNILGAGEVSLERCRKFYELLYARTPKELLGSMARFQPTFRAAKAGQVKAVGFAEFQAILELALGIEPSSSGSKPSSAVSGDRLTLVQPNAGTLGLSDGVTRQKLNEYLIELHEIAGEHEHDSDSDSDSN
The following text describes a protein:
Function:
Serine protease involved in capsid assembly and maturation. Cleaves the major capsid protein, the decoration protein, the portal protein to yield mature procapsids competent for DNA packaging (Probable). Acts as a trigger for assembly of the capsid protein.
Subcellular Localization:
Virion. Note=Present in the prohead I.
Sequence:
MTQAAIDYNKLKSAPVHLDAYIKSIDSESKEGVVKIRGFANTISKDRAGDVIPASAWKTSNALTNYMKNPIILFGHDHRRPIGKCIDLNPTEMGLEIECEINESSDPAIFSLIKNGVLKTFSIGFRCLDAEWDEATDIFIIKDLELYEVSVVSVPCNQDSTFNLAKSMNGHDYTEWRKSFTAISSKAVPAQERNLSELEKLAIALGYVKE
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain (185-210) is required for interaction with COI1.
Sequence:
MAASARPVGVGGERATSFAMACSLLSRYVRQNGAAAAELGLGIRGEGEAPRAAPATMSLLPGEAERKKETMELFPQSAGFGQQDAITADSAADAREQEPEKRQLTIFYGGKVLVFNDFPADKAKGLMQLASKGSPVAPQNAAAPAPAAVTDNTKAPMAVPAPVSSLPTAQADAQKPARANASDMPIARKASLHRFLEKRKDRLNAKTPYQASPSDATPVKKEPESQPWLGLGPNAVVKPIERGQ
The following text describes a protein:
Function:
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis.
Sequence:
MSVELETSEGVDESEKKSSGTPEKENHTRMADLSELLKEGTKEAHDQAENTKFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPLELHRKEALTKDMEYFFGEDWEEQVQCSEAARKYVERIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNLKTKEKIVEEANKAFEYNMQIFNELDHAGSLLANETLEDGLPLHDGKGDMGKCPYYAAKQDKDINERDEKETPQTKIVAPGIEAWQPQSSEARLSFIILFFLKQPEGICILLA
The following text describes a protein:
Function:
Regulates lateral organ growth. Functionally redundant with NGA2, NGA3 and NGA4.
Subcellular Localization:
Nucleus.
Sequence:
MMTDLSLTRDEDEEEAKPLAEEEGAREVADREHMFDKVVTPSDVGKLNRLVIPKQHAERFFPLDSSSNEKGLLLNFEDLTGKSWRFRYSYWNSSQSYVMTKGWSRFVKDKKLDAGDIVSFQRCVGDSGRDSRLFIDWRRRPKVPDHPHFAAGAMFPRFYSFPSTNYSLYNHQQQRHHHSGGGYNYHQIPREFGYGYFVRSVDQRNNPAAAVADPLVIESVPVMMHGRANQELVGTAGKRLRLFGVDMECGESGMTNSTEEESSSSGGSLPRGGGGGASSSSFFQLRLGSSSEDDHFTKKGKSSLSFDLDQ
The following text describes a protein:
Function:
Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase.
Subcellular Localization:
Cytoplasm.
Sequence:
MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIREKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTYEQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAELLHVLLAALENIGVRESVEGAVQA
The following text describes a protein:
Function:
Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation. Essential for testicular stem-cell differentiation and sustained spermatogenesis.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MDVDGSTTCPFDKQGYSSTFKRKRTVEDFNKFCTFVLAYAGYIPYPQEEAHLRNSSSPPNSTGSTADSDGWDNQQLSCSLSSPDEPPPKNRKSFAGFKRPTSEDSEPQKRPKSAGLLLEGRKKADKVKKKKKLRKCKDEDFRNFAPFTPPRVEGEFSSLGRSIKEEPEDYISIPVPSTGFDHPAHTCSKPVSSSQSSAVCKEEPDIEHSCWGGSKSSDQEFEDVKKPSKLEREAMVLKEESFSAKRTVVRQGKQVVFRDEDGSADDEDIMVDSDDDSWDLVTCFCMKPFAGRAMIECNQCNTWIHLSCAKIRKSNVPETYICQRCKDSKFDIRRSNRSRVGSRKHLLD
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MKGILVAASAAILAGGASANRLHHRHLHQPLFEKRVHNDTEICVPGCTTIWTTITGPAGLYTPPAPPSTAVPATSSAITTSEALPTLSSSLVFANSSSTVVPSTSSIAIPSTSSIAVPSTTEVVVVPTTTSQGPVTVPTPIQQTCPTPGTYTFPATTVVLTETKTVCGASSTVVPSGTHTLGGVTTVVETATTVVCPVATTKTAENGVVTSVVELTTYVCPSAGTYTIAPITTTVTDSEPVTVRVPVVETYNPGTYSAPAVVTTITETDVVVYCPFTAVEPPVTSTQAPVVPTTSVAPPVVSVAPPVVSIAPPVVSEAPQEPSSTSSAVPVVSAVPSSSTSSVVPQPTAPTGNLGGKGDKWAMTYTPFTQDGQCKSAADVMTDIKAIANAGFTTLRVYSTDCDTLPSVGAAAEATGLRLILGVFIGTAGCENGSPNVSEQIAAIKSWGRFDMVDLVVVGNEALFNGFCTVGQLRDLITRVKSELGSAGYSGPYTTTDVVSAWQSMDMTDICNVIDVVACNSHAYFDANTAPEQAGTFVAGQLAIVEKVCNKPGFVMETGWPTAGECIGKACPGREQQKTALAAIKQEMGKKVVFFSFSDDHWKQPGSCNCEQHWGCGEIFGVTL
The following text describes a protein:
Function:
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Subcellular Localization:
Cytoplasm.
Sequence:
MRSSYFKIIGKTPLHGTVVPQGNKNEALPLLGAVCMVPGTVRISNIPVISDVLMLMEVLRHLGMEITEEEPGTYIFKHDGNLKNQLPEELCSRIRGAVTLAGPILAMTGRVFLPKPGGDKIGRRRLDTHLLALQALGASIEVFPDGYEIKADQLKGTDILMDEASVTGTENAVMAAVFAEGTTILRHAASEPHVQRLCHFLNSAGAKISGIGSNILTIEGVTSLKPPAKEHKIGSDYLEVGSFISLAAVTGGELMIRDVELEDIRMIRMVYSRLGIEVRPHENGILVPSDQKMEIIPDYHGATPKIDDSPWPGFPADMTSVALVTATQCKGTVLIHEKMFESRLFFVDNIIAMGAQIILCDPHRAIVIGHSRLYGQKVASPDIRAGMAMIIAALCAEGTSYIHNIGQIDRGFENIDTRLRALGARIERVNAD
The following text describes a protein:
Function:
Essential component of nuclear pore complex. Required for the anchoring of Nup214 and emb on the nuclear envelope and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with Nup214, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome. Nucleus, nucleoplasm. Note=Is recruited to non-active chromatin sites. Localization to the nuclear rim is promoted by Nup214.
Sequence:
MSLTDVLELNKTELFAKIRNGLPVVQRTQNLLDCKDDLLFAWHAKDSCLLVRNWRSSLAAKVNIQFQTLIPSSLVSLEVDRVLASNEGSLVALSGPRGVVIMELPRRWGPDGYYKDGKPVITCRTFGLDTQLFLKNPHLEVRQVRWHPHSVSDSTLLVLLNNNTIRVYNHSKLRHVWQVGPPVLRSGANNSLCDFGELAVDFDIAPAAKPRVTEPETAGNNETTLDKSNKTLVAAKSLPKQERIEWPMVVLRENGNIYILMTGVDSENTRLQGPVTITPQAHDNYGLESCALMIIPSLPPTIVIAESNGKLHHALLMEAEATEHSFNEVDDSVLIEPAEYVVHVLETVELELGISAPATGKEGGNCPIYLKRDLINELRYFAYHNAGLHAVTVSFIAELQRYLESESDEDRLELAVSASAEYILCTKFDSSETVNAVFGLALLQIPAGIVLLLGSGQVISLKLVIDAQLLVTPNENKPVDSEVSQQESGPPFVDTIKSLLQRSVNQPILADKLSSPSAQESFELLNQAIEVLREQYLKRHDLVRAAFTRHINQIQLKKEQQLQEIQDLEQERELISERAHKLAERFEEISYNQELLVRKCNALMQRANASLPNSVIAEREFSQEVIRLNKVTQSLAAGLETAKKTFNKQRYHIAQSQEDLKKNAYELPEKQHRTITEILTQLTGEIDRQITDVKRINKIVGI
The following text describes a protein:
Function:
Salivary chemokine-binding protein which has chemokine-neutralizing activity and binds to host chemokines CCL1, CCL2, CCL3, CCL3L1, CCL7, CCL8, CCL11, CCL12, CCL13, CCL14, CCL15, CCL16, CCL18 and CCL23. Binds to CCL8 with 1:1 stoichiometry and disrupts CCL8 homodimer formation.
Subcellular Localization:
Secreted.
Domain:
The N-terminal region is required for binding to CCL8.
Sequence:
MAHKIAIGLVCVLYALHIMSAVCEVSEQEGVGEDNATEDEDYEDFFKPVTCYFANSTVGPLRPPNCTVVCTNNTAWWNDTKSDGGHCYSEYRPEKRTHSREIYNCTIGVCGNGTCIANHTYADCW
The following text describes a protein:
Function:
Required for fertilization. May be required for cell adhesion and/or function as a signaling molecule.
Miscellaneous:
MISCELLANEOUS: Removing the EGF-like repeats in any combination completely abolishes fertilization; MISCELLANEOUS: Modifying each EGF repeat by changing a central cysteine residue to a tyrosine disrupts the secondary structure as the specific disulfide bridges responsible for this overall structure are not formed. The cysteine to tyrosine mutation when located in EGF-like domains 1,3,4 and 5, causes a complete loss of function. The same mutation in additional EGF-like domains leads to a temperature sensitive sterile phenotype.
Subcellular Localization:
Cytoplasm. Membrane; Single-pass type I membrane protein.
Sequence:
MNVILVLVVLFFAGDCAKIRKIIDFLEKDAPNDIEKTPNYNEESLAVKRNKNFNPCLENPKICSNRGKCLHENGNFYCICPVTHYGKTCEHVSDQTNCEKHLCQNNSTCVSIKSLRTIVNTVLLRQIRVQRKVNGSKAALTNEELAEIDLEVNYECICQKGYFGGLCDESEADRTCQEVYCLGRGKGAINATGKCECECENQFFGDRCEQISACFDTQCDNGGICEDVVDWKTKTVTATCKCPSAIELIGGTVTGENCETLQIPSTAPKEFIPCAEGSNSTMFFKKFIANISLEYMDDISELEAIKNDYNDGKNVNGTMTDGWCRNDGKCVPEVVRVNSSRAYYIYRCECTNPLTDGYYCEYKRHDSCSLTREEVARGDRWDEKCTDSQHGACVDISGVAHCVCKPDYTGEKCEIFDPCARQPCKHGDCIPIPNTADVAFGTSRYQCLCPLSAKLNPESQACMEINEKKCAPGACGNGRCVPCESDADDLMPLCNDNDNRQGFRCLCEAGYLPPFCKVHTNPCYQNLCQNSATCHIDPKQRSYDCQCVNGTRGSLCENVDDSCDAFGNKICVHGTCINDEYFHRGFSCECDDGFEGLDCNVEIAWSSVMTNRLMKNYEFSLPLVACFVSLAILLPVIVISRRRQGRVEEAKKTSEVKTENP
The following text describes a protein:
Function:
Sugar transporter involved in the transport of CMP-sialic acid from the cytoplasm into the Golgi. May transport important nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-octulosonic acid) in physiological conditions.
Subcellular Localization:
Golgi apparatus membrane. Membrane; Multi-pass membrane protein.
Sequence:
MEYRRVKDQESYDAISQKDIESPDGRSLSSTAATSPLGTAGGSKGKNSWKQKSIVTIALTLLTSSQAILIVWSKRAGKYEYSVTTANFSVEALKCLLSLLALYRTWNSQGVTEDNRLSTSFDEVSVYPIPAALYMVKNLLQYYIFAYVDAPAYQILKNLNIISTGVLYRIILKKKLSEIQWAAFILLCAGCTTAQLNPSSDHVLQTPIQGWMMAIVMALLSGFAGVYTEAIIKKRPSRNINVQNFWLYIFGMLFNLVAICVQDFDAVMNKGFFHGYSFITLLMILNHALSGIAVSMVMKYADNIVKVYSTSVAMLLTAIVSVFLFGFNLSLAFFLGSTVVSISVYLHSVGKPQQQK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates. Has a threefold preference for the hydrolysis of ATP and UTP over ADP and UDP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFTVMTRQPCEQAGFRALSRTPAIVTLVVLLVSIVVLVTLTLIQIRHPQVLPPGLKYGVVLDAGSSRTTVYVYQWPAEKENNTGVVSQTFRCSVKGSGISSYENNPQDAPKAFEDCILKVKEQVPEHLHGSTRIYLGATAGMRLLRLQNETAAREVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANYIMGNFLEKNLWHMWVHPHGVDTTGALDLGGASTQISFVAGEKMEPNASDTVQVSLYGYTYTLYTHSFQCYGQNEAEKKFLAMLLQSPSTEANISNPCYPQGYSTAFTLGHVFGSLCTEKQRPESYNSSKSVTFMGTGDPRLCREKVASVFDFNACQEQDACSFDGIYQPKVQGPFVAFAGFYYTASALNLSGSFSLTSFNDSSWDFCRHTWSELPALLSRFDETYARSYCFSAHYIYHLLVNGYKFTEETWPQIRFEKEVGNSSIAWSLGYMLSLTNQIPAGSPLIHLPIQPPVFMGVLAFFTAIALLCLAFLLYLCSSFRTKERSENAFDQAVDSD
The following text describes a protein:
Function:
Able to hydrolyze geranyl diphosphate (GPP), farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) to respectively yield geraniol, farnesol and geranylgeraniol.
Sequence:
MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGWLNGLTIDDAFVETQPISEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEEARRRGLKVGVLTNNSLLVSARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEGARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP
The following text describes a protein:
Function:
Inner nuclear membrane protein that specifically binds to heterochromatic regions and promotes the tethering of centromeric DNA to the SUN-KASH complex. Couples centromeres to the nuclear envelope, thus contributing to their association with the microtubule organizing center attachment site and to the positioning of the nucleus at the cell center by microtubules.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein.
Sequence:
MESSRLFTLGLGNSDDGLKSTFGDKTVTCFYCNKKKEKIRDGTSTWTCSICEATNHIDEKGDILDYRPPTPTQDKGVGPFYAIRDFPSSSSFQSPFCEKCQMNQLIVNRMLADYLPDSSHPDYQAYEKALPEYKKSIEEKFPIVCSECYDSVQDQLDANDYEAKNQVLGYWLQKSKEQLNAKVPHHYPKASFVLWLLRGFGFSFFYLQSIVWHLYHSMIISLLPDGIRNLFLKAISYFLLDGSSSKIFYFNWLGFFVVFWNPYWYKMMDNPSWELFGRDQYIQCQALYLIIRLTCLYLLSCYESEILNLSSDTNLESDFLLRQIHAAFFFVTICFTWISISCLKPSPPPEVHLTGEILKPRKKRQESTSSVHRIGKESSDRKDGISGQNKLQQFATISILNNTNATSHLGNQSVRERAPEESPMTFLQKKMAALPTSSPVRPMLKPTLQLQNSPLSKLVPQEVGNKVNDSIHTTSNQPSKFSLNPSISLKGDNVIEKNLPFSVSTLKSTAKKDTGKAGDGQNREIQNEPVSLESHFSKSLALQNDPTEVIQVKNVLHRNRRNAKLLIAFTILFLVGLICGWRLNRFTMFIYYLCILVLATYYVMKHNFYPLRKVA
The following text describes a protein:
Function:
Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MVVARRRSFRIPVTTPPRGYGSRIGARLRRACPGRRSWVWRHCCIPSQDALAMAMISDAPALQRSSEPAEGAAAPSRIARYARPVLGVLLPLALALGWELVVWSGWSNGRLVPPPSRVFVTITDLARSGELVRHIAATLWRVGLGFAFGVVAGTLLGAISGYWSLARRLLDPTVQALRAIPSLAWVPLFILWLGIFETSKIALIAVGVFFPVYLGVMGAILSVDRKIVEVGRTFRLSGPAMIRRILLPAVLPAYVVSLRVGLGLGWMFVVAAELIGASEGLGYLLLDGQQLGKPAQILAAIVIFAMLGKLTDWLIEVGSAPFLRWQDGFGRPRGA
The following text describes a protein:
Function:
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Subcellular Localization:
Cytoplasm.
Domain:
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Sequence:
MDYKSTLNLPVTDFPMKANLPQREPEILAAWQQGDLYGTIAKAGKGKPRYVLHDGPPYANGHIHIGHALNKILKDIILKSKRMQGFDAPYVPGWDCHGLPIELQVEKNLGSKKHETTKLQMRKQCREYAEKFVHVQRAEFERLGVLGDWDRPYLTMSYDYEGITARELARFAENGGLYKGKKPVHWCSSCVTALAEAEVEYADKTSPSIYVKFLLQDDIGGAVPALAGKRVSLVIWTTTPWTIPANLAVALHPELDYVALETGGEVLVVAEGLKDAFMAATGVQGDVIATFRADILYRKRCKHPFYDRDSIVLLGEHVTLDAGTGCVHTAPGHGQEDYELALVEGLDIYNPVDNRGRYIQSLEFFGGMFVFDANAAVMEKLREVGALVGQGSVEHSYPHCWRCKKPIIFRATEQWFISMEKNDLRQKALTEIDRVSWVPKWGRERIHGMIENRPDWCISRQRSWGVPITAFYCTECGEILADGKTMHHVADLFMAGGADLWYEKEAAELLPPGTVCPQCGKSAFEKEMDILDVWFDSGVSHAAVLENRPELGSPANMYLEGSDQHRGWFHSSLLASVGTRGVAPYREVLTHGFVVDGSGRKMSKSVGNVVAPEEVIKKYGAEILRLWVAAQDYRDDVRISQEILTRLAEAYRRIRNTCRYLLGNLNDFDPDVDMVPYDRMTELDRWALHQLEVLKEKVAAAYNEYEFHILYHAVNGFCTVEMSAFYLDIIKERYTSRKDAPERRSAQSVMYLVLESLVTLMAPVLSFTADEVWGYMPKRSESSVHLATFPEFRPEWKDESLVERWARIMAVRGDVSKALEQARVQKTIGHSLDAAVTLAAEPGLLSFLQEYAGELSTIFIVSRVDLVEEGAGDYPAAEGVSGLRIGVSAAPGEKCERCWHYDEEIGGDSEHPTLCPKCAAAVK
The following text describes a protein:
Function:
Involved in resistance against the herbivorous insect brown planthopper (N.lugens, BPH). Member of the BPH3 (BPH resistance locus 3) cluster which contains LECRK1, LECRK2 and LECRK3.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MASTILVLSLLLSVSSAVVGVQDENPNLIKLGSSLSPTIQPSSWSSPSGRFAFGFYQQGNGFSVGIWLVEDPVNTVVWTAKRDDQPVSSDATLNLTTDGWLVLRTGQGEETTHIINASKPASFASMLDSGNFVLYDYNNSSEIIWESFDSPTDTILGGQILMSRNKLVSSESETDHSSGRFYLIMQEDGNLVAYPVNTTKPIDAYWATGTFAYNYNHSLYLYPNGTLMLGSISDFNASSSPSAGRNGTIFRATLDPDGIFRRYSHNFGGNGSRANTTIRWSALHDPCEVKGVCGFNSYCSLVGTKHDCVCLPGFDFIDPNRRFRGCERNFTEEGCLDLKDTVVQYKIISVENLILVDHPFSTEFKDREDCEKSCLDDRNCAAAQFQIDSCKKQKLPLRYLKMNPNVSSTVFFKVSSGFIQSRNRTSESDGNKRLVLIVTVSLGSLTCLFAAIAISSSLIYRRRKVQYTRLLQNGNMGLSEEFTLRLFTYEELEKATNGFKEELGRGSLGAVYRGVLSQDNRIVAVKRLEKIDEGEREFKAEMSAIGRTHHKNLIRLLGFCIEGSKRLLVYEYMSSGSLAQILFNAEGRPIWRERIRIALDIARGILYLHEECETRIIHCDIKPQNVLMDEFWTAKISDFGLAKLLMPNQTRTFTGFRGTGGYVAPEWQKNVPITVKADVYSFGIVLLEIVCCRSNMEVNVSSADEIILSSWVYNCFVAGELDKLVGYEEVDMKALERMVKIALWCIQDEPAHRPSMKTVILMIEGIVDTSIPPSPCLSFVNS
The following text describes a protein:
Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Subcellular Localization:
Nucleus.
Sequence:
MSSEHQTTEHSHNSIIKKKKGIKPFHRVHAHRNPLADSPSTNPITPQSLDWKLYFPNGKPAEMLDIGCGWGGLVREVGMIQEKNVLGMEIRDPAVQYGLEKIQAAREKNELKNVWIIQCNCMKYVDNYFVKGQLLKIFITFPDPHFKNSVKRRRIINPHFAAMYVYLLKPGEGMLYTASDVKELFDWNTQSLDQQPLLERMPDDYTDDYLNIVMFKTEEAKKVDREQRQKWGACYRRRIEEPF
The following text describes a protein:
Function:
Binds to the pentamer sequences ATTGG and CCAAT with highest affinity in single-stranded DNA, and also to other sequences. Has greater affinity for ATTGG than CCAAT. Can act as transcriptional activator of cold shock genes by recognizing putative ATTGG-box elements present in promoter regions of genes induced under cold shock conditions.
Subcellular Localization:
Cytoplasm, nucleoid. Note=Shows transcription-dependent localization at subcellular sites surrounding the nucleoid.
Sequence:
MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEGQAVSFEIVEGNRGPQAANVTKEA
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
ARREADFPLARSALIGAERPGWPPPPPAETEPSPPPPPPPDPLPLLHLPTSLRRLGEGKGEKLSHGRASRPEGPGAPLLRSLVGGGGPAVVPPPCFPFSRPLPLRAASWKPRALPPPPGTRPRPPVRQQAAAAMSNNMAKIAEARKTVEQLKLEVNVDRMKISKAAAELLAFCEEHAKEDPLVSPVPAAENPFREKRLFCVLL
The following text describes a protein:
Function:
Binds cAMP regulatory element DNA sequence. Plays a role in RNA splicing.
Subcellular Localization:
Nucleus speckle.
Sequence:
MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN
The following text describes a protein:
Function:
Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR).
Subcellular Localization:
Membrane.
Sequence:
MEGTGLVALVAKPVLYNCTTIFEPALPLARTTTGRRKKPWINQRPMAFTLYALLEAALLCINAIAILNEERFLAKVGWSSSQPQGYGEEEGVKSKLMNVIKSVQTLLRSEYKE
The following text describes a protein:
Function:
Involved in auxin biosynthesis.
Sequence:
METVVVIVGAGPAGLATSVCLNQHSIPNVILEKEDIYASLWKKRAYDRLKLHLAKEFCQLPFMPHGREVPTFMSKELFVNYLDAYVARFDINPRYNRTVKSSTFDESNNKWRVVAENTVTGETEVYWSEFLVVATGENGDGNIPMVEGIDTFGGEIMHSSEYKSGRDFKDKNVLVVGGGNSGMEISFDLCNFGANTTILIRTPRHVVTKEVIHLGMTLLKYAPVAMVDTLVTTMAKILYGDLSKYGLFRPKQGPFATKLFTGKAPVIDVGTVEKIRDGEIQVINGGIGSINGKTLTFENGHKQDFDAIVFATGYKSSVCNWLEDYEYVMKKDGFPKAPMPKHWKGEKNLYCAGFSRKGIAGGAEDAMSVADDIRSILATLKNN
The following text describes a protein:
Function:
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Subcellular Localization:
Peroxisome matrix.
Sequence:
MAESVELPSRLGILPFRNKVLLPGAIIRIRCTSPSSVKLVEQELWQREEKGLIGILPVRDAAETTTAIGPVLSQDVGSDSSERSSRVHVGASDSHRLDVKNQQENMHWHTRGVAARALHLSRGVEKPSGRVTYIVVLEGLCRFSVQELSTRGTYYTARISPLEMTKAEMEQVGQDPDFMTLSRQFKAAATELISVLEQKQKTEGRTKVLLETVPVHKLADIFVASFEISFEEQLSMLDSVDLKVRLSKATELVDRHLQSIRVAEKITQKVEGQLSKSQKEFLLRQQMRAIKEELGDNDDDEDDVAALERKMQSAGMPSNIWKHAQRELRRLKKMQPQQPGYNSSRVYLELLADLPWQKASEEHELDLKAAKEHLDSDHYGLVKVKQRIIEYLAVRKLKPDARGPVLCFVGPPGVGKTSLALSIAAALGRKFIRISLGGVKDEADIRGHRRTYIGSMPGRLIDGLKRVAVCNPVMLLDEIDKTGSDVRGDPASALLEVLDPEQNNAFNDHYLNVPFDLSKVVFVATANRLQPIPPPLLDRMEVIELPGYTPEEKLKIAMRHLIPRVLEQHGLSSELLQIPEAMVKHVIQRYTREAGVRNLERSLAALARAAAVRVAEQEQAVPLSKDVHRLASPLLENRLADGGEVEMEVIPMAVNNHEISSAFRIASPLVVDEAMLEKVLGPPRFDDREAAERVATPGVSVGLVWTAFGGEVQFVEATATVGKGELHLTGQLGDVIKESAQIALTWVRARATDLKLAASEGISLLEGRDVHIHFPAGAVPKDGPSAGVTLVTALVSLFSQKRMRADTAMTGEMTLRGLVLPVGGVKDKILAAHRCGVKRVILPERNLKDLVEVPTEVLANMEILLAKQMEDVLEQAFEGGCPWRQHSKL