lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence.
Sequence:
MSYNIISHFAAKLTVCADGGANYVFELLDDDRNKYIPDVICGDLDSVNSNAQNYYKDKGTIIVHKSDEDENDFLKCLRLVLQTEPYRNIQCDYIIALGAVHDRFDQSMASIHALYVAAKISRIQIILLSVKSYICLLTPGQHKVLVNTEMEGNWCSLLPIGNKCNNLRTTGLKWNLPGIEFAFGSLISTSNAFDGSNEVTITTDDNVIWSMEINYTLN
The following text describes a protein:
Function:
Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Eliminates the production of nonsense-containing RNAs (ncRNAs). Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding.
Subcellular Localization:
Nucleus, nucleolus. Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
Sequence:
MKEPLQKKKVVVRHLPPSLSQSDLLSQIDPRFADRYNWVSFRPGKSSYKNQKYSRAYVSFKAPEDVYEFAAFFNGHVFVNEKGAQFKAIVEYAPSQRVPKPSDKKDPREGSISKDPDYLEFLKVIAQPVENLPSAEIQLERREAEQSGASKAAPIVTPLMEFIRQKRATVMGPQGLSDIRRGGRRTRVVSANKPSPRPSKRNSEKKKYVEKESSKNVPRKTTADVSSSKPDYRQSNSSGKELPGNETAAIIDSSPPGIALTMDSGKKKILLLRSKDRDNPDNPPPQPEQHIDTNLSRNSTDSRQNQKSDVGGRLIKGILLRNDSRPSQSSTFVQSEQRVEPSEAENYKRPSRPANTRAGKDYHTSGTISEKQERRTRNKDRPDRVMWAPRRDGSEDQPLSSAGNNGEVKDRMFSQRSGEVVNSSGGHTLENGSARHSSRRVGGRNRKEEVVIGEGKTSRRGSGGGPSSHEKQMWIQKPSSGT
The following text describes a protein:
Function:
Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Involved in the maintenance of the centromere and in telomere length. Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats.
Subcellular Localization:
Nucleus.
Sequence:
MNQANFLQELPNVLKRLETGLIIPQLKDILRVFGLRLSGTKAELITRIKQLIERIAIENNTTSWEALKKAIDGDVTSAVCILKYNTYQIYSAAAPIAPPSSASGNRSYSRPFAPVVHSRIRFRKSPFYDILEQFNAPFVVPACVGTRNTISFSFHVTPPALSKLLNDPKQYRVYLFSTPSETIGFGNCLMEFPTPQMELRINNQVAHANYRRLKGKPGTTNPADITDLVSKYAGPPGNNVVIYYMNSTKSYSVVVCFVKVYTIENLVDQIKSRKAESKEKIIERIKNDNQDADIIATSTDISLKCPLSFSRISLPVRSVFCKHIQCFDASAFLEMNKQTPSWMCPVCASHIQFSDLIIDGFMQHILESTPSNSETITVDPEGNWKLNTFDEPVESSEDEFVPKEKVIELSDGEGISTMANKSNDQPTRRASTHNSGPPAKRKRESLVIDLTISDDDENVATSTTESPSNATKENSLSRNVQSPNIDTAISNRSTNVRHGHPGFKDYTVENSPASRERSTSESAQSSVHMGYAGEGGLLSGALRAPSQQNNNNSNTQHSINLHTIVPSPYEPPLSVTPSTAITNLSIPESNRTNSSASSKSFTMNDLILPPLHLKNTTQTNNAHEDAQSSNLSQNHSLFYERIPQRPSYRIEKQNKGIYEDENEQSISAMPIPRAHPQLPKNLLSQTAGPLWDEQQDAQVDWNSELQSNNSYHNSGFEGTGNTFQSID
The following text describes a protein:
Function:
Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Subcellular Localization:
Cytoplasm, myofibril, sarcomere, M line.
Sequence:
MSLPFYQRCHQHYDLSYRNKDVRSTVSHYQREKKRSAVYTQGSTAYSSRSSAAHRRESEAFRRASASSSQQQASQHALSSEVSRKAASAYDYGSSHGLTDSSLLLDDYSSKLSPKPKRAKHSLLSGEEKENLPSDYMVPIFSGRQKHVSGITDTEEERIKEAAAYIAQRNLLASEEGITTSKQSTASKQTTASKQSTASKQSTASKQSTASRQSTASRQSVVSKQATSALQQEETSEKKSRKVVIREKAERLSLRKTLEETETYHAKLNEDHLLHAPEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMHTLEINGCDFEDTAQYRASAMNVKGELSAYASVVVKRYKGEFDETRFHAGASTMPLSFGVTPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTEEEPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIGGGVSPDVCPALSDEPGGLTASRGRVHEASPPTFQKDALLGSKPNKPSLPSSSQNLGQTEVSKVSETVQEELTPPPQKAAPQGKSKSDPLKKKTDRAPPSPPCDITCLESFRDSMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAGPVVAETRPGTKEVVVNVDDDGVISLNFECDKMTPKSEFSWSKDYVSTEDSPRLEVESKGNKTKMTFKDLGMDDLGIYSCDVTDTDGIASSYLIDEEELKRLLALSHEHKFPTVPVKSELAVEILEKGQVRFWMQAEKLSGNAKVNYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQLQDGKATNHSTVVLVGDVFKKLQKEAEFQRQEWIRKQGPHFVEYLSWEVTGECNVLLKCKVANIKKETHIVWYKDEREISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELMMEVCKKIALSATDLKIQSTAEGIQLYSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGEQIWLQINEPTPNDKGKYVMELFDGKTGHQKTVDLSGQAYDEAYAEFQRLKQAAIAEKNRARVLGGLPDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARMAALESLKGGKKAK
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MGKTVNVSGFPPEVNAMEVRQLFESITGSGTIHAIRLKKTKHGEKFYALFQFAQETHANKLLTQSTEVNTPYRLNFHEWKYEIDSKDKASMEHYIDGLLMHFGFLATPEKFKYLYSAGCSFGSGNQNLHFSAHLSEDYRMELPYENIGQISWHLSQEKDSKLLLIQLKGGPKIYENQNQHVDPEYEKLNFCRGGFDNEWIRTTDFPSSSLIGQSSAIVFKFPRELKVDFKNIVINSSLLHYLTLELGFSYSSNTNSLAPVVDPPPEFDLVKITPTRVYFSGPKPHESNRVLREYAKHINNFIIVSFVDENLKTLSCNDLSPRSSVNRKTKPFLSMMLHYIRESKLAELRTKTRILIPKGRSMMGCMDETNTLEYGQVFVRYPTLTLDSKPPYNIIGDVVVAKSPCLHPGDVRVLKAIAVTDLNHMTDCIVFPQKGHRPHPNECSGSDLDGDLYFVSWDPELIPPNTYEPMDYTAEEPQALDHEVTIQEITKHFTNYPLNNNVGTISNLHKVFADKEGEKAGSKQCLELAKMFSAAVDFPKTGVEVKIPPHLYVKEYPDFMQKQDKPMYVSNSVIGKLFRELKKLGPPSILSTSSPPLSHDEDLVFDGFENHIELASDYKKSYNSKLRQLMDTFGIETEAEIVCRGMGMSEPFNESGKMIENAFQSLTKEALSWFNGDEEADELAKASAWYIVTNHKDYVSTDCLDSNQLWSFPWCVYDRLVKIKTETARNKKEEVCKETH
The following text describes a protein:
Function:
ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Note=Forms an intramembrane hairpin-like structure in the membrane.
Sequence:
MPNNDILRPLAIPAKYVGSFLVFLYNGLYFVFVVNLWSRLFGKATKTEVPPLPKIRKLGKDMASRAPPRRGQSSEDNEDGLPAEIFNVRRHHKQAYAYIARALEVDEGQGSLETKKRAVEFYNRGIEEMEAGLLIPCIDEGEEWDKARRLQEKMEANLENTRERMDELVIIFFIIVVALLVSAGMMDDQPLLSARKTSSEPSQAWDVSKPTGPSYKQSKSYKNSTTVTTKRSQASPSFSSSSSSVNSTAGSSRTKPAKPAPMAAPRRYNPQVRRTKSTKPAMMAKQSCVDEQKKKISHLKGIDPKLANIIMDEILESGPAVHFSDIAGVDNAKKALQEIVILPSLRPELWRGDPTLVLFQVLPYPPGSSHITLPRASTATSFTSCFFSISKRSSLVHPVVASFFVKSLEDLASILTTSLFTIDEVDSLLTERREGEHEHSRRLKTEFLVSFDGVVADPEERILVMGATNRPQELDDAALRRMVKRIHIPLPDKETRKVLLTKLLAKHHNPLSGAEIDRLARMTEHYSGSDLTALARDAALGPIRDLNSDQLKSMAANEVRNITFQDFVNSLQIIRPSVGPETLKAYDDWNRLYGSNA
The following text describes a protein:
Function:
Glycosyltransferase involved in the formation of rhamnogalacturonan I (RG-I) oligosaccharides in the seed coat mucilage, which is a specialized cell wall with abundant RG-I. Transfers the rhamnose residue from UDP-beta-L-rhamnose to RG-I oligosaccharides. Prefers RG-I oligosaccharides with a degree of polymerization of 5 or larger than 5. Does not act on oligosaccharides with a degree of polymerization of 4 or smaller than 4. Does not require metal ions for its activity.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MCKMEKFLYHRKLWEMNVKLLGESKVEKLKNSFVSRPRMSLWMIRAVTVLLLWSCFVHLMALGEMWGPRLFKGWPSCFNHHQLSTAAEMTSLPTKIALPPKRVYVNNGYLMVSCNGGLNQMRAAICDMVTVARYMNVTLIVPELDKTSFWNDPSEFKDIFDVDHFISSLRDEVRILKELPPRLKKRVELGVYHEMPPISWSNMSYYQNQILPLVKKHKVLHLNRTDTRLANNGLPVEVQKLRCRVNFNGLKFTPQIEELGRRVVKILREKGPFLVLHLRYEMDMLAFSGCSHGCNPEEEEELTRMRYAYPWWKEKVINSELKRKDGLCPLTPEETALTLTALGIDRNVQIYIAAGEIYGGQRRMKALTDAFPNVVRKETLLESSDLDFCRNHSSQMAALDYLVALESDIFVPTNDGNMARVVEGHRRFLGFKKTIQLNRRFLVKLIDEYTEGLLSWDVFSSTVKAFHSTRMGSPKRRLVIPNRPKEEDYFYANPQECLQLLDEPLRVI
The following text describes a protein:
Function:
Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
Miscellaneous:
MISCELLANEOUS: HIU and OHCU are unstable, they spontaneously decompose to form a racemic mixture of allantoin.
Sequence:
MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSDLHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFLMLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLADIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCEIGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHMDTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYSEIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARYVAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEEIPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Sequence:
MMCLFPSGAHTIGYARCLTFKRRLFDSQGSGRPDPMIDFSLFLRLQNRRPNNDASNSNLAPLDAATILTFDSVYYRNLLSETGLLESDQALIRDSRTASMAYFYSTDQSSLYNDFAASMVKLSNVGVLRGIQGQIRRTCGSLNYYVLDIFNFLAKPQQYN
The following text describes a protein:
Function:
Multifunctional regulator of the expression of viral genes that mediates nuclear export of viral intronless mRNAs. This immediate early (EI) protein promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP (By similarity).
Subcellular Localization:
Host cytoplasm. Host nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Domain:
Binds viral intronless RNAs and SR proteins through the Arg-rich region.
Sequence:
MALSSVSSCEPMEDEMSIMGSDTEDNFTGGDTCAEATRGLVNKSAFVPTQTVGTVSALRNVVGNPPKSVVVSFSASPQRAQPSNPKSERPAFGHGRRNRRRPFRRNNWKQQQRGWEKPEPENVPARQSAGSWPKRSSLPVHMRLGQRGGDSSSADSGHGGAGPSDRWRFKTRTQSVARVHRNRRRGNANHGSNTPGRSAGDRLNAAAARSIADVCRRVTSSRIGEMFHGARETLTTPVKNGGFRAENSSPWAPVLGFGSDQFNPEARRITWDTLVEHGVNLYKLFEVRSHAAEAARSLRDAVMRGENLLEALASADETLSWCKMIVTKNLPMRTRDPIISSSVALLDNLRLKLEPFMRCYLSSSGSPTLAELCDHQRLSDVACVPTFMFVMLARIARAVGSGAETVSRDALGPDGRVLADYVPGACLAGTLEAIDAHKRRCKADTCSLVSAYTLVPVYLHGKYFYCNQIF
The following text describes a protein:
Function:
Could be involved in the secretion of the yop virulence proteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNPHDLEWLNRIGERKDIMLAVLLLAVVFMMVLPLPPLVLDILIAVNMTISVVLLMIAIYINSPLQFSAFPAVLLVTTLFRLALSVSTTRMILLQADAGQIVYTFGNFVVGGNLIVGIVIFLIITIVQFLVITKGSERVAEVSARFSLDAMPGKQMSIDGDMRAGVIDVNEARERRATIEKESQMFGSMDGAMKFVKGDAIAGLIIIFVNILGGVTIGVTQKGLAAAEALQLYSILTVGDGMVSQVPALLIAITAGIIVTRVSSEDSSDLGSDIGKQVVAQPKAMLIGGVLLLLFGLIPGFPTVTFLILALLVGCGGYMLSRKQSRNDEANQDLQSILTSGSGAPAARTKAKTSGANKGRLGEQEAFAMTVPLLIDVDSSQQEALEAIALNDELVRVRRALYLDLGVPFPGIHLRFNEGMGEGEYIISLQEVPVARGELKAGYLLVRESVSQLELLGIPYEKGEHLLPDQEAFWVSVEYEERLEKSQLEFFSHSQVLTWHLSHVLREYAEDFIGIQETRYLLEQMEGGYGELIKEVQRIVPLQRMTEILQRLVGEDISIRNMRSILEAMVEWGQKEKDVVQLTEYIRSSLKRYICYKYANGNNILPAYLFDQEVEEKIRSGVRQTSAGSYLALEPAVTESLLEQVRKTIGDLSQIQSKPVLIVSMDIRRYVRKLIESEYYGLPVLSYQELTQQINIQPLGRICL
The following text describes a protein:
Function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
Subcellular Localization:
Cytoplasm.
Sequence:
MMKKGIAASKGYAIGKIFIKEDINIEVVEKSIDNIEEEKERFKSALSNTRDQLERIKDKAQKEVGAEKAAVFDSHIMLLDDPEFAGAVEMNIESNKVNSEKALQEVIDMYSSIFASMEDEYMRERGADIKDVGKRIMLNLMGKSVNSMDDLDKDTIIVAQDLTPSDTAQLDKEKVIAFLTNIGGRTSHSAIMARTLEIPAIVGMKDITESVKNGDVVIVDGIEGIVIINPDKETIEKYEESKRTFLKEKEELKKLINVETITREGKRVEVCGNIGKPQDVHQVLENGGEGVGLFRTEFLYMDRDNMPSEDEQFESYKYAVEKMEGRPVVIRTLDIGGDKKLPYLEMPEEMNPFLGYRAIRLCLDRKELFKVQLRALLRASAFGNLKIMFPMISSLSEFRAAKELLKECMSELKSEGKEFNENLETGIMVEIPAAAICADELAKYVDFFSIGTNDLIQYTLAADRMNEKISYLYDPMHPAVLRLIKMTIDAAHKEGKWCGMCGEMAGDENAIETLVEYGLDEYSMSASSILTAKKIIMNS
The following text describes a protein:
Function:
Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Dubious isoform produced through intron retention.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAAEVLPSARWQYCGAPDGSQRAVLVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQRILAAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSVESELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSALGPGVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQRDLKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKIT
The following text describes a protein:
Function:
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.
Subcellular Localization:
Secreted.
Sequence:
NAAAGGSASDAISRRPSGGARVAERRNLKLVSIVTLKTICWRCQSQKRQETSAYSRGVLRRDTHKSEIAHRFNDLGEKHFKGLVLVAFSQYLQQCPFEDHVKLVNEVTEFAKKCAADESAENCDKSLHTLFGDKLCTVATLRATYGELADCCEKQEPERNECFLTHKDDHPNLPKLKPEPDAQCAAFQEDPDKFLGKYLYEVARRHPYFYGPELLFHAEEYKADFTECCPADDKAGCLIPKLDALKERILLSSAKERLKCSSFQNFGERAVKAWSVARLSQKFPKADFAEVSKIVTDLTKVHKECCHGDLLECADDRADLAKYICEHQDSISGKLKACCDKPLLQKSHCIAEVKEDDLPSDLPALAADFAEDKEICKHYKDAKDVFLGTFLYEYSRRHPDYSVSLLLRIAKTYEATLEKCCAEADPPACYATVFDQFTPLVEEPKSLVKKNCDLFEEVGEYDFQNALIVRYTKKAPQVSTPTLVEIGRTLGKVGSRCCKLPESERLPCSENHLALALNRLCVLHEKTPVSEKITKCCTDSLAERRPCFSALELDEGYVPKEFKAETFTFHADICTLPEDEKQIKKQSALAELVKHKPKATKEQLKTVLGNFSAFVAKCCGAEDKEACFAEEGPKLVASSQLALA
The following text describes a protein:
Function:
Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MWKIRCVCPFEDDDGFTIQCESCEVWQHAVCVNIDANNVPEKYFCEQCQPRPIDADKAHKIQLARLQREEEQSRILSRSRSSNNKRRTSFGKNGASPTHSASPRQGNNTGANGALFSQSTNSSNSGSYRNSVTGATLPNAHAPHSQNRRRRSNHLNNPPEAPITEASNEYVYSFHLEYVPLESNTFSASALEYSKNLDLKNLDESEVLMDGCQVVPISSSKFCCSRFGLVSTCEIPPNTPIMEVKGRVCTQNEYKSDPKNQYNILGAPKPHVFFDSNSQLVVDSRVAGSKARFARKGCQSNSVVSSVYMNGSNSVPRFILYSTTHIAPETEIIGDWTLDISHPFRQFAPGMSRPSFNMEELELLSEVLSTFLSFNECASQDKKNCVFSRVTKYIKAARRASTANRVSVAKDRLSLTPSSTPSTPSPAESLPQPSNPTSVYAKSLKEFWLDKYRLSILQKWPAVKSLPTESVGIDVVMEPKLQPSVKEKKPTKDLQSPLPSVEEDSSNRDKKTDIADLHTDSKVGIADVLSPISPDAALQSDGPLKKAKEPEESSITPTTPPSFNVGESLSRRSASPLQHPRTSPDMLDKTSPCKRGLGTITTVHKKHGSVDHLPSVKRRRSIANDFHGKPDYNKRSLSIERKPEAFKTKGDRPHKVHPSFHRNSDSKLKLEPSSKEKSGSMFFNTLRTVKDKSHVHDTQRSSDVNFSRQNGTRSHSPSVSPVGFSFDKSPVTTPPLPTAPAPVITSRHALVNNQFPTNNPNILDHKANNGDDISNALNTSRSENKPNSNLVQGSVVKPSNTSASALPTSAPKKLSLSEYRQRRQQNILHQQSKDNQAHGDTARPHTVPAATVSNPSFTR
The following text describes a protein:
Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Sequence:
MAAGEDGALSREAVLDYLDSHPEFAGEYVSRARATQGRDGVPIVNWQAQQLFSRRRGSRHFDQHPETALGVSTFFPRRPLSPARRYNLRKRSPRKQPSLEKLSKLNELDLMLELIRDIANELDMTNLCHKILTHVGILTNADRCSLFLVKGSRDNKFLVSRLFDVTPDSSVEQAMNATGSHEIRVPFGCGIVGHVAKTKETVNIRNAYEDPRFNRTVDQRTGYHTHSILAMPICSADDEVLGVAQIINKATGGHEFTDKDEEVFRNYLTFCGISIANAQMFEMSITEYKRNQILLQLARNIFEEQTSVDKVVHKIMKDAQDLLKCERCSVFLTEDLHEQFSLLFESQRRRRQSLDLSAHPSTEPPRLSAGIPKTSAQGVDFSKIFDLVSGNDADKGVQSPSASTVAWLLESGLAKHVASTGEVLNLQNTGEDSRFQFTEEAETGFRIKSALCLPIYNRERKIIGVAQLLNKHNNELFDENDEGMFEAFAIFCGLGIHHTQMYENVCRLMSKQKVALEVLSYHATAREEDVGKLLSTISQTAQMPAATKIGLYDFRFNDFVMSEDETIQGAVRLFLECDLVNKFRVPYDVLCRWVLSVKKNYRPVTYHNWRHAFNVTQTMFVILKTAPFSSMFSDVEIFAMMTASLCHDLDHRGTNNAFQSKIESPLGRLYSTSTMEHHHFDHSIMIMNSEGNNIFQSLSDEDYRQAMSILEDSILSTDLALYFKKRGSFISRAQGGATDWTVEDNKSLLRAMMMTACDVSAICKPWEVQKKVAELVYSEFFQQGDIERTKLHQKPIDIMDREKKDELPKMQVGFIDSICMPLYKVMAEKWPSLHPLYEGCRTNRDHWQALSQQKTTIVLPEQTDTTSTGKRLASTSSTDDNHSETSTSDTGHSTIQTSEINLSGKLAVSSRECSTTDIVDKSADFTSKKTPLEHLILANKPKVAQDTDIQRICEEKRKEISWKRYTPADSKGQRIVQEAALKPRHAREEIVSHGQRTSSQPQQLCKKISRISLHCTDLEDVPREHIHNSRVCAIL
The following text describes a protein:
Function:
FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Oxidizes thioredoxin in vitro. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space, and can act independently of the oxidoreductase MIA40. Can oxidize the cytochrome c oxidase assembly protein COX19, a typical substrate of MIA40.
Sequence:
MPENPLQALFHNIEQVSSFVQHHLSNFIGIHFQPSGPHSGSLLSISSSTKAPLAKTASSVQLGDTAVKGKSAAPVTKEELGRATWTFLHILAAQYPDNPTRQQKKDVKELVQMLPRIYPCGECRDHFKEVLRANPVQTGSHAEFSQWLCHVHNVVNRSLGKPIFPCERVDARWGKLDCEQNACEIIGSTSIFRKIWKKST
The following text describes a protein:
Function:
Protein disulfide isomerase of ER lumen required for formation of disulfide bonds in secretory and cell-surface proteins and which unscrambles non-native disulfide bonds. Forms a complex with MNL1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MKFSAGAVLSWSSLLLASSVFAQQEAVAPEDSAVVKLATDSFNEYIQSHDLVLAEFFAPWCGHCKNMAPEYVKAAETLVEKNITLAQIDCTENQDLCMEHNIPGFPSLKIFKNSDVNNSIDYEGPRTAEAIVQFMIKQSQPAVAVVADLPAYLANETFVTPVIVQSGKIDADFNATFYSMANKHFNDYDFVSAENADDDFKLSIYLPSAMDEPVVYNGKKADIADADVFEKWLQVEALPYFGEIDGSVFAQYVESGLPLGYLFYNDEEELEEYKPLFTELAKKNRGLMNFVSIDARKFGRHAGNLNMKEQFPLFAIHDMTEDLKYGLPQLSEEAFDELSDKIVLESKAIESLVKDFLKGDASPIVKSQEIFENQDSSVFQLVGKNHDEIVNDPKKDVLVLYYAPWCGHCKRLAPTYQELADTYANATSDVLIAKLDHTENDVRGVVIEGYPTIVLYPGGKKSESVVYQGSRSLDSLFDFIKENGHFDVDGKALYEEAQEKAAEEADADAELADEEDAIHDEL
The following text describes a protein:
Function:
Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria.
Miscellaneous:
MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
Subcellular Localization:
Peroxisome.
Sequence:
MEISERVRARLAVLSGHLSEGKQDSPAIERWCTSADTSVAPLGSLKGTLTIVDERTGKNYKVPVSDDGTVKAVDFKKIVTGKEDKGLKLYDPGYLNTAPVRSSISYIDGDEGILRYRGYPIEEMAENSTFLEVAYLLMYGNLPSESQLSDWEFAVSQHSAVPQGVLDIIQSMPHDAHPMGVLVSAMSALSIFHPDANPALRGQDIYDSKQVRDKQIIRIIGKAPTIAAAAYLRMAGRPPVLPSGNLPYADNFLYMLDSLGNRSYKPNPRLARVLDILFILHAEHEMNCSTAAARHLASSGVDVYTAVAGAVGALYGPLHGGANEAVLKMLSEIGTVENIPEFIEGVKNRKRKMSGFGHRVYKNYDPRAKVIKNLADEVFSIVGKDPLIEVAVALEKAALSDDYFVKRKLYPNVDFYSGLIYRAMGFPPEFFTVLFAIPRMAGYLSHWKESLDDPDTKIMRPQQVYTGVWLRHYTPVRERIVTDDSKESDKLGQVATSNASRRRLAGSSV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MATTDSMQGLDDVRRGAAGGSADSVLTWQGDRHEESGEESGGRDKGVRVYRCEECSKEFSKLCNLKTHTRTHTGEKPYRCEECTKQFSQLSDLKTHMRTHTGEKPYRCDECNRQFSQLGHLKSHMRTHTGEKPYRCEECSRQFSKLSNLKTHMQTHTGEKPYRCEECSRQFRNLSNLKEHMRTHTGEKPYRCEECSRQFGVLSSLKRHMRTHTGQKPYRCDECTRQFRQLGDLKTHMRTHTGEKRYRCEECSRQFSELGNLKKHMQTHTGKTEGVRDGTESSVNFIPDIADMATTEGMQGLDDVMRGAAGGSADSVLTWQGDRREESGEESGRRDKGVRVYRCEECNKQFSKLSNLKRHMRTHTGEKPYRCDECSRQFSQLGDLKSHMRTHTGEKPYRCEECSRQFKRLSILKTHMRTHTGEKPYSCEECSRHFSDLGHMKRHMHTHTGEKPYKCEECSRQFSQLSDLKRHMQTHTGEKPYGCEECSCQFSRLDSLQTHMRTHTGEKPYRCEECSRQFSVLSNLKTHMRTHTGEKPYSCGECSRQFSQLSHLKSHTRTHTDEKPYRCEESAAGSSVC
The following text describes a protein:
Function:
Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the stereoinversion of O-ureido-L-serine to O-ureido-D-serine.
Miscellaneous:
MISCELLANEOUS: It employs a two-base mechanism, with a thiolate-thiol pair in the active site.
Subcellular Localization:
Cytoplasm.
Sequence:
MIRMRTPSTLPFTKMHGAGNDFVVLDLRDGPDPSPELCRALADRHKGVGCDLVLGIREPRSARAVAAFDIWTADGSRSAQCGNGARCVAAWAVRAGLARGPRFALDSPSGTHEVDVLDADTFRVALAVPRFAPESIPLFGHDGEQDLYEADLGDGTRVRFAAVSMGNPHAVIEVDDTATAPVARVGRAVQASGLFLPTVNVGFARVESRDRVHLRVHEYGAGETLACGSGACAAAAVLMRRGRVDRNVSVVLPGGELRISWPDDAADVLMTGPAAFVYEGTFLHASV
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection, neuron projection. Midbody. Golgi apparatus.
Sequence:
METVSLVPLEGLDDLSAQSAAIKKIEQNFSNIDSLASVTNHKISLIQQKKTIEAQIKNEVHSELEKSKKGLETLYKSYNRINRMDESFSDTVELCSETSNLIGHYQLIKKVNTVRVNLINILKEVDRLLTIPEKAAEIEQLLSDDLNLLEIHSKLRELERLHQKALKQFESNFEELEAIKEMFSSVPELSHRFENKIWNIVSNSIDIAQIKPAVLVKVAQIIEREKLHEQKQKEKKSQNSLISSEGIHDDDDDDDDTEVNLNNSNKQQNNENENSSSNNNNNYDINNEDEGYDRNRSNYGDRFLEVLIQSISGKFEPMFLNSHNDLVQTLKDVNKMVDELFIVMDIVQECYPPSYDLFNFYVDQYHTKFYSLFGSFSNLMESSHVNNNYQVVVTKNIPSAHILMLVEWVVKNYSRDLSRLGIQDISPPLLDSLDPLIKIYKMHIKQLMREWCDNIINNDNQNKPEVVDGQYCSLAPIQLFESVASQLDIAAATKCQKLVVGVMEEVVSALMYFQVQSITLLQERNHEIKLENVIAYVNNNSKCYDHTQTIVDKVSNILDSEHMGYLDFDPVLEGFLNVSKVATQAISSVIFRDLDECIHKFYTVEWYQEDLMQPIINTFEDYVTNDIQKYILENYLKRLALLLLDTLIEQLLAQLIGGKNKFNENTYKILSNDCDKLLDFFKKYLRLSVVTAKVQILEDFKQMITSSIDMVPVYFRSVINFHKDINERVVELVLYQRTDISKSEITEVLGQIKTIVETVHTDPTNPPTGIFSRMNIYQRGWFS
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSSAQRVEHLQKIQSAYSKCKEYSDDKVQLAMQTYEMVDKHIRRLDADLARFEADLKDRMDGSDFESTGSRSLKKGRSQKEKRSSRGRGRRTSEEDTPKKKKHKSGSEFNDSILSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVDLTTKPKGKWFCPRCVQEKRKKK
The following text describes a protein:
Function:
Sterol 14alpha-demethylase whose physiological substrate is not known. Accepts electrons from the iron-sulfur ferredoxin Fdx encoded by an adjacent gene. In vitro, catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol, to produce the 8,14-dienes stereoselectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV