lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cell surface proteoglycan.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MALPRLHPLLLLLLITPATLSSLTFTDTRSCTDTDRELRDRGLGGTAGVRAPISGEHLRICPQEYTCCTSDTEIRLSEESMSDLVRIVNESLSFPWGALTTGKKKFHKFFLALLDASEHSLSSMFVLSYGRLYSQNAALFSTLFSELRAYYMGGGASRVADALSEFWAGLLERTLRLLFPQYQLSADYMECAAHKAEELRPFGDSPRRLRLQITRALGAARTLVEGLGTGSDIVSRAAKAAPPPDCLQAVMRMWYCPLCRGHSNLRPCHGLCLNVLKGCLAHQADMDDDWNSLIDGLQEVAERLAGSFNIELAMESIAVKISEAIMSLQEESVQLTAQIFQTCGTPPPGRSRRSPGEDPRQRFRVYSNDEKPTSADGTNIDRLVSEIVGKLRPLRGLWKLLPLSLCSDNRVSAGLSNQEKCWNGQNRGRYLPQVTGDGLVNQINNPEVELQMSSVNPKARSLGLQLRVARSKLRAAYSGQDSDTQDVYDDGSGGSGGGDIATDKPVIRTVAGGTQLKDRTGKNKKQNNRGAGRGGKRGGSGLSNVGRPITPSGLALTVTLLLGALMRV
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAETIVTFQSQLSGVMETVFKAAMFEITRLVEDSFLEEVTRCREQVESLRKRLRWAESRSREKQDDTRDTCAKCGRAGPNKPAAAEFSSPEKNLKQESVIPEEEAGSLENSAQVHNQDMEEAHCTGNAMHPLNAQDDHFGGQFKEEPLQTMTEINEVQEWDMRSQEADPSSLQGSSKRFSEPKIAKWETGFEQGAEPSQEGHSAYSSEALFQSRYGMDQLGGVEEAANENTSMMGMASFSHMQGSSSHLGGDLADLNQCTDKNAMEMAERADHHCYQTVIPQKRRLAPSPPAASPEKANLNEKEAFTCLLIDEEGYLQDTNVPHASSDAGILLGFRGQGIPFNQSSSQGLYESSNACSGTLNLSDTLQHQTASKGGRRDASNSCSASFPNSVSLKTHKRTQKSTKQGVPFSRNQSTKSFSQACNLQAHQKTHSAQELHLCSHCGRGFSSFEDLRSHKCGQIGDKPYCCTVCGNKFSRLWNLKLHQRIHTQEKPHRCNMCDKSFTRADILKIHQRTHTGERPYCCSVCNLSFKRLDHLKSHQRKHINL
The following text describes a protein:
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, telomere. Note=Associates with major heterochromatin, centromeres, sub-telomeres, rDNA and the mat locus.
Sequence:
MLASNSDGASTSVKPSDDAVNTVTPWSILLTNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGRLHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFEDWKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSLLVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISKNIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLVFVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ
The following text describes a protein:
Function:
Pheromone that is regulated by the circadian clock. Expression is mating type specific and under the control of the mating type locus. Involved in conidiation.
Subcellular Localization:
Secreted.
Sequence:
MKFTLPLVIFAAVASATPVAQPNAEAEAQWCRIHGQSCWKVKRVADAFANAIQGMGGLPPRDESGHQPAQVAKRQVDELAGIIALTQEDVNAYYDSLSLQEKFAPSTEEEKKTEKVAKREAEAEAQWCRIHGQSCWKKREAEAQWCRIHGQSCWKRDALPEAEPQWCRIHGQSCWKKRDAAPEAAPEAEANPQWCRIHGQSCWKAKRAAEAVMTAIQSAEAESALLLRDTTFSPVDRVGKRDPQVCNMRLHPKKVCWKRDASPEAACNAPDGSCTKATRDLHAMYNVARAILTAHSDEN
The following text describes a protein:
Function:
Is essential for the biogenesis of the T-pilus, which is required for virulence and T-DNA transfer to plant cells. When is associated with virB7, might function as a nucleation center for recruitment of VirB proteins during assembly of the T-DNA transfer machine (By similarity).
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MTKKAFLTLACLLFAAIGARAEDTPTAGRLDPRMRYLAYNPDQVVRLSTAVGATLVVTFGANETVTAVAVSNSKDLAALPRGNYLFFKASKVLPPQPVVVLTASDAGMRRYVFSISSKTLPHLDKEQADLYYSVQFAYPADDAAARQKAAQEKAVADRIRAEAQYQQRAEGLLEQPATTVGAEDKNWHYVAQGDRSLLPLEVFDDGFTTVFHFPGNVRIPSIYTINPDGKEAVANYSVKGSYVEISSVSRGWRLRDGHTVLCIWNTAYDPVGRRPETGTVRPDVKRVLKEVRG
The following text describes a protein:
Function:
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Subcellular Localization:
Nucleus.
Sequence:
MANIMIPSKRPRAPSFSEKHPKYVGSSDWLPAEKDKAQVQLTNFLELCRFCKKNLRHDEDVFMYGYLGAFCSKQCRAKQMACDVFRDFSRQKANVKKGRTSKDEGLDRISSSPSSSSSSSCFYI
The following text describes a protein:
Function:
Probable transcription factor that regulates lateral organ polarity. Promotes abaxial cell fate during lateral organd formation. Functions with KAN1 in the specification of polarity of the ovule outer integument.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing KAN2 develop elongated and pointed cotyledons, and do not produced subsequent leaves, resulting in seedling lethality.
Subcellular Localization:
Nucleus.
Sequence:
MELFPAQPDLSLQISPPNSKPSSTWQRRRSTTDQEDHEELDLGFWRRALDSRTSSLVSNSTSKTINHPFQDLSLSNISHHQQQQQHHHPQLLPNCNSSNILTSFQFPTQQQQQHLQGFLAHDLNTHLRPIRGIPLYHNPPPHHHPHRPPPPCFPFDPSSLIPSSSTSSPALTGNNNSFNTSSVSNPNYHNHHHQTLNRARFMPRFPAKRSMRAPRMRWTTTLHARFVHAVELLGGHERATPKSVLELMDVKDLTLAHVKSHLQMYRTVKTTDKAAASSGQSDVYENGSSGDNNSDDWMFDMNRKSRDSEELTNPLEKSNGLWTNSSGEARLHGKLIDNVAEIMLPSEKELDGKCSSYERISSEEMSSSSISGTSPFKPNLEFTLGRSH
The following text describes a protein:
Function:
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Required for proper pollen function. May stabilize the interaction of TFIID with selected promoters. Not redundant with TAF6B.
Subcellular Localization:
Nucleus.
Sequence:
MSIVPKETVEVIAQSIGITNLLPEAALMLAPDVEYRVREIMQEAIKCMRHSKRTTLTASDVDGALNLRNVEPIYGFASGGPFRFRKAIGHRDLFYTDDREVDFKDVIEAPLPKAPLDTEIVCHWLAIEGVQPAIPENAPLEVIRAPAETKIHEQKDGPLIDVRLPVKHVLSRELQLYFQKIAELAMSKSNPPLYKEALVSLASDSGLHPLVPYFTNFIADEVSNGLNDFRLLFNLMHIVRSLLQNPHIHIEPYLHQLMPSVVTCLVSRKLGNRFADNHWELRDFAANLVSLICKRYGTVYITLQSRLTRTLVNALLDPKKALTQHYGAIQGLAALGHTVVRLLILSNLEPYLSLLEPELNAEKQKNQMKIYEAWRVYGALLRAAGLCIHGRLKIFPPLPSPSPSFLHKGKGKGKIISTDPHKRKLSVDSSENQSPQKRLITMDGPDGVHSQDQSGSAPMQVDNPVENDNPPQNSVQPSSSEQASDANESESRNGKVKESGRSRAITMKAILDQIWKDDLDSGRLLVKLHELYGDRILPFIPSTEMSVFL
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. The NSL complex also acts as a regulator of gene expression in mitochondria. Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA. Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells. This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA. Plays an essential role in spindle assembly during mitosis. Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly.
Subcellular Localization:
Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle pole. Note=Concentrated in the nucleus during interphase but displays a marked relocalization to the spindle poles during mitosis.
Sequence:
MFRPGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWNAHPDASSARPTRMLFVTPRRQPEASGDSDMSIDVETVTPTPMPLYDNQKARSVMNECDRHVLFARTVADGPPPPDDWEEHINKTGWSLAQNKLFNKVLKALQAERLGRLANDGACNEPVLRRIAVDKCARKVRHALSSVSWDIKLTHWLHNTLLESLSLAMLAAYLDVLQTLKSKVPSLIDRMLLSSSVKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIAPSGPTNPAFPTSRRMRFWQSQLSCLGKVIPINVHVGSGANVGITQCLEHMIGTVRGKVIEVHSHFPHKPIILVGWNVGSLMACHVSLMEYMTAVVCLGFPLQTISGPRGDVDDPLLDMKTPVLFVVGQNALQCSPENMEEFREKIRADNSLVVVGGADDSLRINSTKMKTEGLTQTMVDRCIQDEIVDFLTGVLTRSESHGHGSGETRDLDAEKKKPRRELPFDLDRSRPSSPAVRDMSSVCSSPTASPKPKTVGLSPAQKSSLITATQLLKTHMQRSGTVLTHKQAQAQFAAFMKHNMLVRKSIPPGSPSCLFVPVPSEQVEGLERDDMRVHLKRRQTPSPTPTKASKRAKIKVTIVSHGDAAGNTPGSTAQEVGLSGKPLGLTVGQTTVSGAKELSELLSAQRSGGLAEVSGALASSEGSFHSLQGSVISRSSSPVQAAGTAQAPSASSLLQGLSLSLQEINTKSPGVPSTTQVSGGKPQGQGQVLSSLSPGSGTLVRAVPMVSTGSGMTKTTAIHQLLTNGGLAKLANSLPGLAHVSSQSSGTSSTPRSKQRRPR
The following text describes a protein:
Function:
Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.
Sequence:
MSYEKVWANNEKLNQTEKNKLEKDGLEIFNDIPYYAENGFESIPKEEWDAFKWAGLYLQRPKEAGYFMMRVNIPSGIITNAQAEVLASIAEDYGRNVIDITTRQAIQFHWLEIQQIPDIFKRLARVGLSSAGACGDITRNITGNPLAGIDANELFDTTHIVKEVYDYFQHNEEFSNLPRKFKMSISSNIYNSANAEINCVAFTPATKEIDGEKKVGFHIKVGGGLSARPYLADELDVFVLPEEVKAVAIAIATIFRDFGYREKRHLARLKFLVADWGAEKFKEKLIEYTGPLQSKGESALKGWNAGYFYGVQDQKQKGLKYVGFNVPVGRLHAEEMFEIARIAKQYGNGQIRTCNSQNFIIPNVPPENVKGLLSEPLFEAISASPKSFIGHAVSCTGIEYCNLALVETKERLRKIAEYLDTQIALDVPVRIHMVGCPNSCGQRQIADIGLQGVKMKTKEKGIVEAFEIYVGGTLLDGGAYNQKLKGKIDGEDLPDVLASFISYFKENKLPAETFYDFVGRVGVDTLQIALNNVLEEVIAS
The following text describes a protein:
Function:
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular Localization:
Nucleus speckle.
Sequence:
MSFQATTKVHVKSGVVMWGTTSPPLPIGFPFVMDQAAIMALVMSASDATNGRDSERSRRSSTDSDMAIPQTPIDAPSDPFDFKLVADMPDEDMVSKFMASMKSSATKRCSKREMSAVSPREERIKRPMNAFMVWSQQRRQQISATGQKFHNSDISKMLGVEWRAMADEEKVPFVERAKQLREEHFITYPDYVYRPRRRKRIVKSTGSFESAPSDELGDFPNNNNSLVCSMMLQQLMCCLKTMQKSVDSEANNLI
The following text describes a protein:
Function:
Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MPLSKVEHYLSYHTRLLLPHVLSLQSSHRVAYIFSLLSAVSTGFITLISLYSQPWQKHLNYSSWQINTIASMTNLGMYLTPPILGMIADSHGPITLSLLAIIGFIPSYSYLAYVFNHPELSLGGNGDSSFNLSIICFVFIGISTSALYFSALLTCTKLYPHTKLLSISLPTTCYGISSVVGSQLLRIKWFWSSNASSSSSNSDLNLGRVFQTFALVYVVIGLLAWIATSVVSLLHFNEEQDNQKRLDDQTDVEQSPLLERSNHVQEKFTQTMLRIFSDPVTYILAVSILLSLGPLEMFIANMGSLTNLLVQLDAPTLSTKLLSTYALSSTFTRLLTGIVADFFAKKKISIKWILLTFLSLGVCAQLFLLKMTSSASPWGLVPTGSLVGIVYGGLFTVYPTLVLLVWGERSFGTVYGSLLIAPAIGSMIFCMLYAKFYDSRCMSGGGDLRNPSCISAVYKYSSIAFVVSAVLSAVVFWKLKSRKLRI
The following text describes a protein:
Function:
Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MRYAFNESLKDDDSGDHDQDQSSPKDSETIKIEDDEKEQNTTKKKMVVPGAGEHPLQYNYTFWYSRRTPGRPASTQSYEQNIKQIGSFASVEQFWRFYSHMIRPGDLTGHSDFHLFKEGIKPMWEDDANKMGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQGTTARIRDTLRRVLNLPPNTIMEYKTHTDSIKYVCLLSLLFSLHLLL
The following text describes a protein:
Function:
Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The first fibronectin type-III domain mediates a specific interaction with Hh protein, in vitro. The second fibronectin type-III domain is additionally required for in vivo signaling activity (By similarity).
Sequence:
MTLLTSSLLLFSLLTSRLEAIPVLEKSPAHPAHSAHTAHPAHPSPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLRTGTAKANVSQEAAISRLRVLVRPDTLGEYRCVGWFGPLVVTSTTARLELASTSLVDAQESEAPLQWRVSAGNSVLWSCGQQVQSNPSASWSYFRNGVEIKPEFIGTNGNLFLSNVSSESSGIYSCQATNPASGERIQLPGSMQLQVTPEQRSQSKSPHLLKGQPSSQEITIREGSSLLLQCPGVGSPPPTVVWSSPDVVGAVKNKRSKVFGHALEISNTRVHDAGTYICFQDNGVRPALEHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECEATGVPTPEIYWLLNGHSSVDDTEAELSNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSKQKQMYPPTPPNVTRLSDESVMLRWMVPRNGGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTASVTDLKPEHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWSLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAVSASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVLILLLISTCLCVCRRRTSRSRGNNPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHITLNPLAQQQQQALEEKNDTDQDAPYYQRPSSYDYDPTLRRMSSSSLRRSQRTLERAGGSNGSNNGNNNNLNQSAEAGAVENPGKPGRVLMKRPRLSSRSENLSSGSLNSVGV
The following text describes a protein:
Function:
Chaperone necessary for the incorporation of Rieske iron-sulfur protein UQCRFS1 into the mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPLSDFVLALKDNPYFGAGFGLVGVGTALALARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGHISTKFEFVPSPGNHFIWYQGKWIRVERSRQMQMIDLQTGTPWESVTFTALGTDRKVFFNILEEARELALQQEEGKTVMYTAMGSEWRPFGYPRRRRPLSSVVLEQGLADRIVRDIREFIDNPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAAENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHVDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAEAFAERVLQATTQISPAHVQGYFMLYKNDPAGAVHNAESLRR
The following text describes a protein:
Function:
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity).
Subcellular Localization:
Cytoplasm, nucleoid. Note=Localizes in tight foci on the nucleoid; targeted to the nucleoid via the 35 C-terminal residues of SSB (ssbA).
Sequence:
MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSILDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEMKVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSLKGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQAEKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSMQKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAWRQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELETVTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEELNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQHTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIKRTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYEAFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESIISELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHEAQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDLKLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSITRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETVAALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVFKGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVSSLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQSDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM
The following text describes a protein:
Function:
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Cell projection, neuron projection. Endoplasmic reticulum membrane; Peripheral membrane protein. Lysosome lumen. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein.
Sequence:
MGSRHFPARTVLFERETSGVTYRVPALLHIPCVAKLLAFAEERLSVDDAHANLLVLRRGSFYKNFVEWEDMRALETATLPHHRSMNPCPIYDELTGMVFLFFIAVLGRTPEAFQIITGENAARLCYVTSSDQGISWSHVTDLTQHVIGRAIDDWATFALGPGHGIQLKSGRLLLPAYAYHIDCRECFGKLCKTTPHAFTFYSDDHGQSWQYGEFIPNLQTVECQMVSVDEEDGTNLLYCNARSPLGFRVQALSTDDGAVFHAGQLVQRLVETPHGCHGSIIGFPAPLYYMHGNVCRFQKTTWSAKGTSFVLQPETDERPKPFCSPPTISLCSQPIGCQQQQEMFALPRTCSPKHSIIPGHITSDTADINQNNQEGRTISQSGIIFQIPTWVLYSHPTSSRSRVNLGVYLSTFPRDADSWSEPWIIYEGPSAYSDLAYIQLPYSEVSITGIPAIAFACLYENGVRTPYEQISFSMFTLHEVLQNIPLATSSARLKKPEGRKRKKRSCVLF
The following text describes a protein:
Function:
Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. During development, specifically regulates the migration of HSN neurons, the left Q neuroblast (QL) and its descendants and the distal tip cells of the gonads. Positioning of Q neuroblasts may be both dependent and independent of hox gene mab-5. Involved in establishing ALM and PLM neuronal cell polarity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note=Traffics between endosomal cell membrane and the Golgi apparatus membrane and the cell membrane to mediate wnt/egl-20 secretion. Co-localizes with snx-3 on intracellular punctae and early endosomes to facilitate recycling and wnt/egl-20 secretion. Localizes to the basolateral cell membrane of intestine cells, but not the apical cell membrane.
Sequence:
MAGGAVIENLSNRKLFVIFAGLLVIQIMFFLIGAWYAPSPSSYMEFEMITCRDETKGLSGEWIHRDNCQQISELSEYTPSSFDLREIVFIAKMPHTRDGIELEYSPWFQFLLGVLHVDVEYSEHFKYVAHAPLELEVRMGYRDKESKKNEWKELVTSNVTRILECTIAEDEKKAGGTYDCDMLDLFELGSSSYPFYLINIRIPINQQACQFDNKSANCQIGKLTGLRLIEIHQNGGFTLVWLWTKTFMTPVVAICLWWYYNRINQLARNPLLLERAILLLGLSLVILDFPIEWISLTYRIPFLLLISDLRQGLFYTVLFSFWLIFAGEHLIDDNTRNNLKSYRFNLSFIITASLGLLIYDLIERGIQLYDPFYSVWSSPTGSQIAYFAIFISAISTVAYFIFLFFKIARVWSTIKSKRSAQIYQTSENRRLKVEGVIYRFKFLMLFTLLCSAFTIAAYFMKQYGEAQLHGDEARDGFLTGSTSAFFTGAFGMCNIYVLLLLAMYAPSHKHYRGASQLIDENDDDEIMEDPSNQHTESNAMTTFLKPSTD
The following text describes a protein:
Function:
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Domain:
The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
Sequence:
MVRTSSQTRGQNSGIRPGNLWKGLGETGAGQETGASDYAQEGRSPSGTLLGQPIGELETGQGPGQDSCPHSGIGQQPEAGWEAGFWATVPFLWQCRHIYHSEKAPVTGIFLLSSASQLRVSFYQRPTVPGVTPSRAHSLVESILALSHSFKYSSLRIYPLSLLPQALMQLEMNETIEQMLIQSYEFEKLRDFRPIVSEFWSISLVLALIYLGVIFMGQRYMKKRKGFNLRLPLTIWSFTLAIFSILGAMRTWRYLGAVMMWGGLKNSLCHIGFVTNPTVRFWSLLFVLSKIVELGDTAFIILRKQKLLFLHWFHHSTVLVYTSFAYKDAVAGAYWFMTMNYGVHAFMYSYYTVKALGLTPPRFLPMIITTLQITQMFVGAFVSILSYLWGKDCACYTSTQYLFWTFAMYLAYFALFLHFFYKAYFRTAQTKAKAKSQ
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MEIIPAPTMPIPMLMLFVFFVRGNRVGIAEVGEKLRSRYVFMAAFVTGGCFAPRFHPGSIAVPTASKNAAPMKLRSLRDVPAILDEKVGLGEVLSRKPKGSAKRKTKKSDDSVSLAFSGVWGGIRGLLAAALTRHHPHVLVLLPQAVDADIVAGDVSSFGIEDVVALPLSAGDGTGSSIRDADYAARLQVLQRLRARDQHSPKPLVVTSYIGAAIQRVPSVTSLEKATRELAVGDIVDPEVIRRWLAEAGFAAVTAVQVPGEFASRGGLLDVYSPDQPQPIRIEWFDDEIESIRRFDAATQRSSETLSKVELAAIGTQPVKSPFAEEENNDEPLDLVVDDTVGAEATIVDYLPEDTVVLVIDPSDCHQSSNALLARVAKTERFVSMRELLSELKSHKVVTGTSLAEGAPSDVVDLHTASADSFATSLDETKSKVDSVAAGHEVIVVGDTPADGQRLTELLEDTDAAKQGRLHMTVADLSGGFRLTDAEILVLTGAELFHRSPVRRAKTRTRGKPIDSFTQLTPGDLVIHLSHGIGLYRGLNSIEKNGQHQEHLTIEFDGGTKIHVPASRIQLVQRYVGGTKNRPKLAKIGGISWTNQKKAAEAAVTDMADELLELQAKRATRLGIPMSPDNEWQRQFDASFPYLETPDQLSAIEALKIDMEAPRPMDRLICGDVGFGKTEVAMRAAFKAVSSGYQVAVLVPTTVLAEQHYQSFRERMAEFPVEIRKLSRFCTPAEQRETVKEIRRGKADIVIGTHRVASKDVEFNNLGLVVIDEEQRFGVAVKERLKTQHSNVDVLTLSATPIPRTLHMALVGVRDISNLETPPAERMAVETKVTRWDDKMLRSAIVRELNRGGQMYFVHNRIGDMDDLAARIKAIVPELRIGIGHGQMEEGALEQVMVDFIDHKFDMLLATTIIESGLDIPNANTMFIDDGNRYGLSDLHQLRGRVGRYKHQAYCYLLVSPNKRLTPEASKRLRAIEEYSQMGAGFAISMRDLEIRGAGNLLGSQQSGHIAAVGYEMYCQLLEDAVRQAQKLPPKLSADVDIDLPIEAYLPEDYVPNLRHKIDLYRRMTRIEKAADVKAIREELEDRFGSPPPPAIRMLELCELRLDAASWGLVSLTTNDRFIVLQYSNRSRMNQLAKNSSIPIRIVDHEKAYIPIKDYDMSDPAGKAWLQLARAALWIG