lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Involved in host defense at the body surface. Causes agglutination of the Gram-positive bacterium S.difficile. Possesses calcium-independent hemagglutinating activity.
Miscellaneous:
MISCELLANEOUS: Binds beta-galactoside inhibiting its haemagglutinating activity.
Subcellular Localization:
Secreted.
Sequence:
MDFVEVKNLIMKSGMELKVNGVFNANPERFSINVGHSTEEIAVHVDVRFSYLSDKRQLIINHKTGDAWQEEQRDARFPFTAGQAFQVSVVFNFDTFDIYLPDGQVAHFTNHLGAQEYKYIFFVGDATVKNISVNVADKPTKR
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MATRVVPQKIIKNLRFKTTTKPLNSYHPSATATVASILEREQPSPPQPSHQQPSYLDLNDGERLFSAVPTSTLIRSSAVLHATAIGPVVDVGIWAMQSKLLQTGILKDAVMAVTKRTFYEHFCAGEDAITAGKSIRSVNEAGLRGMLVFGVEDAHENDGCDRNLKGFLHTVDVSKSLPPSSVSFVIVKITAICPMALLERISDLLRWQQKDPSFNLPWKQDSLPIFSESSPLYHTTKKPEPLTPQEESDFQLANQRLQQLCKKCVEANMPLLVDAEHTTVQPAIDYFTYSSAIMHNKDDNPIVFGTIQTYLKDAKERLFLATKAAEEIGIPMGFKLVRGAYMSTESTLAESFGSKSPIHDTIEDTHNCFNDCSSYLLEKFANGKGSVVLATHNIESGKLAAAKAYEIGMGKVNHKLEFAQLCGMSDALSFGLSNAGFRVSKYMPFGPVEMVMPYLLRRAEENRGLLAASGFDRQLIRKELGRRLKAAIF
The following text describes a protein:
Function:
Carboxylate--CoA ligase that may use 4-coumarate as substrate. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
Domain:
Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.
Sequence:
MIRIINGQTYFTSKYPNIIIPEKPIPHLILKHIRYKPDQVLLVDGLTFKEYSSHFVADTIEKVACGLNKLNIKKGDVLGVILPNLPEYVPIFHGTLLMGGITSLVNPDYTIEELSHTLATVSPRYLAVTLAVYEKIKNDLKRVFPSVEKVILVDIAGQTLKEIDQLTLSSDGIVMSFNQLTNNNGKDYPIVRIDLTKDTAIIPFSSGTTGLFKGVCLSHYNLVSNTYQTQTIETSTYKKNDSVIGVLPFFHSFGLMLHIMLMVKQGYRIVTLPKFEPVRFLELIKKYKVAMSFIVPPIAIMFAKSPIVDKFDLSSLRTLFCGAAPLGSEIEDLIKERFKGRLVIKQGYGATELSPCCFVTPNGLVKSGSSGTLLPNLLAKIISSETGENLGMGEKGEICIKGPNVMLGYYNNEKATNEVIDKDGFLKTGDIGYVDEDGYFFIIDRSKELIKCKGFQVPPAELEALLLSHPKVADACVVGLSKGDMGEVPRGFVVIKQNESLTEKELLDWAHPKIANYKHFRGGIFFIPAIPKSATGKLLRKNLKDFNNLKL
The following text describes a protein:
Function:
Mediates calcium-dependent cell-cell adhesion during the early stage of development.
Subcellular Localization:
Cell membrane.
Sequence:
MSTMATNNNNSENLGFNKKDEMIYATLYPNDNNEDSALTIFTDTSKTNEKTHYKRCFVSKDTILLVWTDNNFNPRDDDDLSKGKYLVFNPNSCNILPENQFKFKVKEIEKNTFFANIKLQSSKKQYSLSITPLECDIQTYQSGNDYAPLIIHTLHEDEFVDCQISLKDSTGSVITHGKIFFKYNHNDGIVDYNEAIGFPEKLQINCFDKNCFIFVVNE
The following text describes a protein:
Function:
12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities. The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA. Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B. The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively. The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B. Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties. In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
Sequence:
MTIPTEISCPEEDAFQLLDKFSWFPSDDQRRWWEYTGPYLLKLLRDAKYPQKDQVPCLYLLQQLLVPYLGTFPVVGQAPLPWWSNVTTYGVPFELSWNLLHNIVRIGFEPLSHLAESGVDAFNKTAPEECVSRLACLDNTIDLARFRHFQHHLLVTPEEETWLLREKAPLPKSGRGQQTLAVEFQNGGISAKAYFFPGMKSLATGLSPGKLILDSIERLALPGLKEPVHHLRSTLGLQDDGHPTDTAIAPFLLGVDLCTPERSRLKFYVTDQVVSWDRVADMWTLRGKRLEDPQCADGLALLRKLWDLLAIPEGYRSNIRPDFAFGTPPPEDYRPVMMANWTLSPKKKFPDPQIYLLTVGMNDAVVMDALVAFYEVLGWTDLASTYKDKVASYFPGPDFTKTNYIHSGVSFSYRHSKPYLSVYYSPF
The following text describes a protein:
Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
Subcellular Localization:
Nucleus.
Sequence:
MSTTAVFIPPQIMVTSNVEKVPISIITHSSDSNFIAYRLNNKLNIFDNKLNKLGELESGSQHTGIIRSIEFTKNNQSLITSSSDKFLKIWDTTNNFKNIKSINTNKKIICSILNKDDSEILVSDKCGDVFKYSLIDDSKNKIEVSGDKSAKHDEKESDKNLVFGHYSSIVDIKFSPCFNYLLSADRDEKIRVSHYPNCFDIESFCLGHTKYVTEILLVPGRDDLLISGSGDGTIKLWNWKQGKCLQTVDFNSKHENAITIPQVVFKVDATTTTNQLIFSIENSNNIYILPMNVEKGEFNQSELKTIPLTQSSPISIDLIDNGKTILASLLPTTKEVDVAIAFDSTTLSQQSDNKVVIAINSVDASTTLKPAELKSVLESIEKKQYRKHVSYSKQMMNSTDNKNKEDDDLSLDEQDIDDTTDINNNNKNKNQETIQDSRPLKLRKMTIEGDKEIQKELEEKESKKQEE
The following text describes a protein:
Function:
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTGKRGTAAGTDGSGNKKGKREFKAKLSGLLAEQTCRDSVKEAWEGNQGGQFGSVALDSVPFPHGVIHPFIHNSDFLEELKEELLNLNFQPKSNDLYQFKQSEDLKNRKESHIKALRHVLFEDFRQWLSNITNVELEKTVDISCAQYGYTDTLLCHDDELEGRRFAFILYLVPEWSKSDGGSLDLYGMDDNGQPGPIVKSLVPRWNSLVFFEVSPVSFHQVSEVLSDGKCRLSVSGWFHGCSLERPPRGLDHPPVRSPHIPHDDQILYEWINPSYLSLESQAQIQEEFEERSEILLKDFLKADKFQAICAALETQSITLEKCGPPNKRCYDRAHGDFPGVIGSCMELLRSEAFFLFLSNFTGLKLHFLASNNEESDEGEGPSEPNTVSQQGASSEDDKVPSCSGELRHWQHSYYTMIHDLDPERHEFALDLLLFCGCDDWEAEYGGFTSYIAKEEDEELLTVYPENNCLALVYRDKETMRFVKHINHKSQQRDAKNTKHKGFWDFAFVYYE
The following text describes a protein:
Function:
Involved in peptide utilization.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MHALPLIGIAFLLYAFGYFVYSKYLAEKIFQLDDSRPTPAKEINDGVDYVPTNKWILLGHHFTSITGAGPIVGPAIAVIWGWLPAFLWVVLGAVFIGGVHDFTALVTSIRHKGKSIGTILGEYAGEKARVLFLLLLLALAILVNAVFAYVISLLFVKYPSSVLPAWLVIPLAVIFGFSVYRLRVNFLILTVIFLSILYFGIYLGSVSPIDVKPLAESLGLSPIMLWIIVLFTYAFFASSLPVWVLLQPRDFLNGLQLLILLILLYIGAVIANPKIVAPAVNLNPEGAPPIFPFLFITIACGALSGFHALVSSGTSSKQLEKESDARAVGYLGFMGESSLALAVIIATTAGIAMFSAEKFQELYSSWSSIKSSSLVAVVDGGANLLGAVGIPVDFGKTVIATLVVLFAATTMDTSVRIQRYILGELGEIYGVRLLTNPWVASGVAVLTSMALVLSKEGGKGGMVFWPVFGAANQLLAGLALLIGYLYLKRVNRPTLPILIPMIFVLFITSLAMAMNAWNNLMKGDLLLFSVSFIILLLEMFIIFESFRAVRRAPAF
The following text describes a protein:
Function:
Member of the two-component regulatory system CssS/CssR required to control the cellular response to secretion stress.
Subcellular Localization:
Cytoplasm.
Sequence:
MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTPSPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISKPFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKEFDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGFGYRMMSS
The following text describes a protein:
Function:
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. msd1 is required for microtubule nucleation from within the mitotic spindle and for localization of Grip71 to centrosomes and mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle.
Sequence:
MSDAVDKMLAGMAANRQTMNRQLAKIDEIMERSNNTLLHIESNSKAFSQNVALSETQKMYNLRPEAEMTLSKILENFKLLMSSSDQREETYSALEGCLAYRHRVEHLGSSVRKLVALYDTVGQMKNSQEEQYASEDSP
The following text describes a protein:
Function:
Component of the NuA3 histone acetyltransferase complex. The NuA3 HAT complex has 2 functionally distinct forms. NuA3a binds H3K4me3, through the PHD finger of YNG1, and acetylates H3K14 at the promoter region of actively transcribed genes to promote transcription initiation. NuA3b binds H3K36me3 at the coding regions of actively transcribed genes, through the PWWP domain of PDP3, and coordinates transcription elongation.
Miscellaneous:
MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
Residues 156 to 543 compose a region conserved in chromatin associated proteins.
Sequence:
MNRGSLDDGPKLREEKHFQDFYPDLNADTLLPFIVPLVETKDNSTDTDSDDISNRNNREIGSVKSVQTKELIFKGRVTTEPLVLKKNEVEFQKCKITTNELKGKKNPYCVRFNESFISRYYHINKVRNRKSYKQQQKEFDGVEAPYFTKFSSKEAPNITISTSTKSAIQKFASISPNLVNFKPQYDMDEQDELYLHYLNKRYFKDQMSHEIFEILMTTLETEWFHIEKHIPSTNSLIARHNILRDCKNYELYGSDDGTGLSMDQACAVCLGTDSDNLNTIVFCDGCDIAVHQECYGIIFIPEGKWLCRRCMISKNNFATCLMCPSHTGAFKQTDTGSWVHNICALWLPELYFSNLHYMEPIEGVQNVSVSRWKLNCYICKKKMGACIQCFQRNCFTAYHVTCARRAGLYMSKGKCTIQELASNQFSQKYSVESFCHKHAPRGWQTSIEGINKARKYFSLLSTLQTETPQHNEANDRTNSKFNKTIWKTPNQTPVAPHVFAEILQKVVDFFGLANPPAGAFDICKYWSMKRELTGGTPLTACFENNSLGSLTEEQVQTRIDFANDQLEDLYRLKELTTLVKKRTQASNSLSRSRKKVFDIVKSPQKYLLKINVLDIFIKSEQFKALERLVTEPKLLVILEKCKHCDFDTVQIFKEEIMHFFEVLETLPGASRILQTVSSKAKEQVTNLIGLIEHVDIKKLLSRDFIINDDKIEERPWSGPVIMEEEGLSDAEELSAGEHRMLKLILNSG
The following text describes a protein:
Function:
Major alcohol O-acetyltransferase that uses acetyl-CoA to synthesize acetate esters from various alcohols, producing ethyl acetate, isoamyl acetate, isobutyl acetate, butyl acetate, hexyl acetate, heptyl acetate and octyl acetate. The alcohol acyltransferase activity is promiscuous with regard to alcohol but relatively specific for acetyl-CoA since ATF1 does not use any other acyl-CoAs (C3, C4, C5, C6, C8, C10, C12). Acts also as an efficient thioesterase in vitro with specificity towards medium-chain-length acyl-CoAs. In natural environments, the production of aromatic volatile metabolites promotes dispersal through insect vectors.
Miscellaneous:
MISCELLANEOUS: Present with 1990 molecules/cell in log phase SD medium.
Subcellular Localization:
Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Traffics to lipid droplets during the stationary phase.
Domain:
Segments of the N- and C-terminal domains (residues 24-41 and 508-525, respectively) are predicted to be amphipathic helices and are essential for endoplasmic reticulum and lipid dropplet association.
Sequence:
MNEIDEKNQAPVQQECLKEMIQNGHARRMGSVEDLYVALNRQNLYRNFCTYGELSDYCTRDQLTLALREICLKNPTLLHIVLPTRWPNHENYYRSSEYYSRPHPVHDYISVLQELKLSGVVLNEQPEYSAVMKQILEEFKNSKGSYTAKIFKLTTTLTIPYFGPTGPSWRLICLPEEHTEKWKKFIFVSNHCMSDGRSSIHFFHDLRDELNNIKTPPKKLDYIFKYEEDYQLLRKLPEPIEKVIDFRPPYLFIPKSLLSGFIYNHLRFSSKGVCMRMDDVEKTDDVVTEIINISPTEFQAIKANIKSNIQGKCTITPFLHVCWFVSLHKWGKFFKPLNFEWLTDIFIPADCRSQLPDDDEMRQMYRYGANVGFIDFTPWISEFDMNDNKENFWPLIEHYHEVISEALRNKKHLHGLGFNIQGFVQKYVNIDKVMCDRAIGKRRGGTLLSNVGLFNQLEEPDAKYSICDLAFGQFQGSWHQAFSLGVCSTNVKGMNIVVASTKNVVGSQESLEELCSIYKALLLGP
The following text describes a protein:
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
Miscellaneous:
MISCELLANEOUS: E.coli produces two separate class I enzymes. This one is the functional enzyme during growth; MISCELLANEOUS: A substrate-binding catalytic site, located on R1, is formed only in the presence of the second subunit R2.
Sequence:
MAYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSNFQL
The following text describes a protein:
Function:
Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro).
Domain:
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence:
MGISFSNNNRRRDNNNRRHLHHYPPPPPYYYLDPPPPPPPFPPHYDYNYSNYHLSPPLPPQPQINSCSYGHYHYHPQPPQYFTTAQPNWWGPMMRPAYYCPPQPQTQPPKPYLEQQNAKKVRNDVNVHRDTVRLEVDDLVPGHHLVSFVFDALFDGSFTITFFAKEEPNCTIIPQFPEVYSPTRFHFQKGPGQKFLQPSGTGTDLSFFVLDDLSKPLEEDVYPLVISAETIISPNSISEQSSVHKQVTQAVLEKDNDGSFKVKVVKQILWIEGVRYELRELYGSTTQGAASGLDESGSGTECVICMTEAKDTAVLPCRHLCMCSDCAKELRLQSNKCPICRQPIEELLEIKMNSSDEQH
The following text describes a protein:
Function:
Required for microtubule stability and anchorage by binding to the minus ends of microtubules. Acts redundantly with noca-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, morphology and integrity of the epidermis. Promotes microtubule stability and polymerization in neurons. Involved in the maintenance of neurite morphology in ALM and PLM neurons. May play a role in synaptic protein localization in the PLM neuron. May act upstream of dlk-1 in neuronal regeneration. Plays a role in postembryonic epidermal tissue integrity and wound healing.
Subcellular Localization:
Cell projection, axon. Cell projection, dendrite. Cell membrane, sarcolemma. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Perikaryon. Note=Localizes to puncta throughout the dendrites and axon of neurites, within the cytosol of muscle cells and at the sarcolemma. Expressed in puncta along the dendrites of neurons and in the perikaryon. Localizes along microtubules.
Domain:
The CKK domain binds microtubules. Might be required for microtubule stabilization; The Calponin-homology (CH) domain might negatively regulate the CKK domain; The coiled-coil domain contributes to microtubule binding and might negatively regulate the CKK domain.
Sequence:
MDFPLPALLAIEDYDENEGKLAASIRWLISRVYEEKRDMPDKLRDGVQRDENGHFQIDEAVVGALCNGSLYAQAAAKIFKESALVTKGHGAVLAVLTDYGIDVLHDGNELVEEAQLVASAPFNMSAHLAIIDALMMAHLRDVIPVSRVVEAVSRHTAVEPSEKPIDSVDALLFWINKICLLVRDDVEREDSNTNIPEMEDLYEDISDGQCLCALLHWYRPHEMPVADISFNDSATTRDCQYNLMLLQLFCRHHLAVDPFHFEIEDLLYLRDSLQMNVNAFLADLFVQFEPPVTPEPVETPRIGPSPRRFVPASAIPDLRAANAAARSSMHNRNRPRMYNPPPAVSHSQGPSRSVSRMSQDSLFYSRPASIALQRRSMDQDSVTDFQTIRQGFENQAGTAQLNRYDGSVTASVRLAMEEKRRKHDQQMAQMSFSSANETERLEKSKAAFFALRKNDNDQTSKGKEEWYDHFEAKLRALELRVGLEEGEDGTQSARLNRASSQPSVVQAGQTYPANYMTLPMNAAAQMTQSYIQHPQTPHDYYMQQQMQQQQQQQAQAQSNYASPSQLRNSLSNGMINHAGYIVQSMYPGDYQQQQQQMQMQQGQMPVQPVGAYTPEGYFIPHHMQPIPVQQGYQQMPQPGMGFNGMPATSQPGFNMEGSPAQMGYIQTANKPLDMEMPMQQQPPQQPPQQMLPPNQNAFHLHSKSDDATQVQADPPLEINRNLTNWGMTYKQEMPARSIPSRRTWQNETFIKNELDLVNSKESVPHITDETTTQPEEAARRFPDLMLDNHSENLAPGRGFSRQNDRDDLSTGRKSDDSPTDTPGRTFDDDEGSGENMEKIANERRIAKKAALIAKTMKRKEEIETKVDLAEQRNAERRQVENEKKELALRKKVEKEQQRQKILDEYKRKKLEKELGAELSARSTGRGHSQPPFIRTKSQMSEVTESSRQNTPRMRGQSSVEQRVSVSSLAEPTHKLYAKTVTKSNRGLINNALQFSVFPGAVNNATRQATITQMASSSSKHFLILFRDQKCQYRGLYTWDEISDTAVKISGQGPPKCTEAMMNSMFKYDSGAKNFTNIATKHLSATIDGFAILDQYWQKARIPHSGTPAHKNN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MIFSDNEESKPINCDMCKKRFRDAHSLQKHNNIHLSDDDPRKIRFECDICHKFLTERGALLTHKRIHMDDEEERFPFKCDECGKRFTQSSNFKRHKIQHHSKTERESFECDICGKRVTTKGSLVAHKLTHVVVSRLYLKYRYIEDENMLENDFEFAFQIIQESSIQVLRNSNLKTNNICNKKEIIVIFEIVTLEPVIDRPYKCDMCTAAYTMPWALKMHKQKDHVNNGKQTTNGTDNLSKWPNSRIGEATSRKFQCVFCNKIKRSLQSHCRTTHDNDEEAKRPFKCEQCGQRYTQSQHLQKHRNTHLATEDPQKITFQCDKCDKKYHWKEALMRHKRSHLEDEEARKPYKCQECGKRFSSTGGLQSHLNKHLCEFCRTFKMEDFVSAADDPRKQKFQCKICGIFLTDRSGLRRHLITHNDWKNAESRNTGNFK
The following text describes a protein:
Function:
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body.
Sequence:
MDRADNNRDLNAVSNRLAAQTEHLQGHLQQQLNLNGAGQARNMFASRPAGLASLGEDAEATSDSAQTPSTFHRQGGPRFAGNAAFQSALARHSNQTGNSINSSSAADFRANLSHQRQLSLQSRFADLGYNVGSGLGAAPSEADDMTDDGSVGYGASAFDPTRGQRSHASDFSFGSSGTAGSHRRTGSDMSGMLSNRGGHQPAASVGGNSNSLSAQSQMLAEQQIALQQQIEMLQLQQQQLMHSAGLGQQGSVGNSLNGSSHSFGGHRRIQSHAPRSGPMGSFSTAGAFNGGALANFAPSQPATPTPSLPRGHGRRHSVNVLNKANQQQQQQQQQQQQQQQQQQQQQQQQQQQPSQRQADAQQQRNSPNAEPMQSNGPVMHANPDFSFPSTASAQRTAQAAYQATQPTAGHYSRPSAQLTDLSADYLMAGGGLVSLNSFNVSSSMNDLADGFGGAGAGGPRPGHARGNSTQWRINGGVQAPQLVDLAQAQAHLAMLHQFRESAAVTGHYRAPSLGGAFNSMAAGFGANQFGMGATNGPGAIQRKALFGNYLPQGTLPTLLAHGKIVVGVLRINKRNRSDAYVTTEVLDSDIFISGSKDRNRALEGDLVAVELLDPLEVWNVKKEKEDKKKRKEEQSGQFSRKPDKAKDDLEVEGAQLRLIEDEEENEQSPPQLAGHVVAIVERSPGQLFSGTLGLLRPSSAATKEKQQAERVQREGASALAPEVKPRPKIIWFRPTDKRVPLIAIPADQAPEDFWAEEGQESFNSRLFVACIKRWPITSLHPFGALVEEIGVIGNVEAETQALLKDTLSSATEAFTEGALKCLPPLPWKIPEKEYKTRRDFRSHRVFTIDPETAKDLDDAVHVVRLDNGNFEVGVHIADVSHFVKLGSSLDREARKRGTSVYLVQRAIPMLPPTLSEELCSLVPNVERLAFSAVFTMNKDAQVISSWFGKSIIKSCAKLAYADAQKVIEGGQLSKEKLEAHRPKEIGDDILILHQLAQKMRARRFKTGALRIDNVKLSFKLDENGLPTDASVYCSYDAHRLIEEFMLQANMAVAQQIAAGLPELALLRRHEKPLDRRLDGFLRRAKSMGYDIDTSSGGALHRSLAKIKDDSARQALQALVTKSMMQAKYFCTGMVDIAKYHHYALNVPLYTHFTSPIRRYADLMVHRQLEAVLVEQDKFGVDREAMAKIAQQCNVKKDAAKMAQEQSAHLFLCLLIHDLTMRYGPVVRSATVMGVLDAAFDVIVPEFGIEKRVHVDQMPIENHTYDEQTNALSIYWKDNVDVIAWLAENSDDVHVKKLQEVAQQHQMMELTSQSSHDEAALFADDDDDESCTAAILRQHNIDAAKDSRQRAKSLQKVALQFDGVEHHTRVQKINELMKVPVIVTSDMSKSPPVLKVFSVNPFASG
The following text describes a protein:
Function:
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MKKTEDATDDNLDCEADEFSDEASAESLYNTFPTSISRQMKRMSSKNQWNNTGRPVGHFTFNEKMSRPNPSPHKESSKTTGNVEDHNYKQEKKNRATLRMTERDQKKNVQCSFLLDPGSGPLTKKSIPDVDLNKPYLSLGCSSSKLPVSVPVSLARTTRQSSRTDCPADRLKFFETLRLLLKLTSVSKKKEREQRGQENTSSMGYNQSNELFWLELQAWHAGRSINDQDLYLYTARQTIPDIINEILTFKVNYGSLFSDADNINGTFRERPFIVSPGSFAFGHSSYHEHIQKQKISFEQVKQIMDLLEYIEALYPSLNALQRDYEKYAAKDFQARVQALCLWLNITKDLNHKLRIMGSVLGIKNLSNIGWPVFEISSPCPSNCPEDEHDNIEHEGQIHDGAPRMCREEREEEELTINNLDLRQDFNSKLTVNFFEEDYSSSNKLDKIMSEDDFSWGNPECNDSDCNRHCSTSIYRPFVDKALKQMGLRKLILRLHKLMHGSLQRARRALMMADRTFDFSEYPDLMLCSDYLPDLLKQSRSTVQSSEPACDPVSWEELKSMDLPSFLPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLREVLDDLQKLDCDIDSFEDDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITPLIRGGEAQAGKLFCDIAGMLLKSTGKFLDSGLLDSCDEFWASTDDSSISDEIRRSVIETSRALKELFHEARERASKALGFAKMLRKDLEIAAEFTFASTILELLAFLKAKDYAKVLIPSVENLHVFIPGNLSREKIIVQQLLGTAAGIDCSKDCEDMAYDQFLLMTKHIDKDKPQEDWNSWDGCCIKSMPPVETADTLRSMQTDNLLLVVMQSAHLQSQRKAFQHSTEGLLSLRLEQTSSHPMIAEALFQLKSEALQLCNEISSAIDRVDKMFTNESEAEIDESESSTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKTGDKYINFARKWMNFVLTKCESGRGTRPRWATQGFDYLQAIEPVFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYIATHRNSPRPVKVPRCHSDPPNPNLITPTPEGFRGSSVPENDRLASVASELQFRSLSRHSSPTEDREEPSYPKGELWGSTRRSWELQTFISQTRDIAARHRPMNAIQESVKQFEDERYRQMRNKNIVGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISIDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYTKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITQAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIPDRLSPEGKDFLSHCQESDPKMRWTASQLLDHAFVKVCTDEE
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKTKKGKGRLDKFYHLAKEQGFRSRAAFKLIQLNRKYNFLGKCRTLLDLCAAPGGWLQVAAKTMPVGSLILGVDLAPIKPIRGVKTLVQDITTQQCRTAIKREAGGAKMDVVLHDGAPNVGGAWASEAYNQSSLVLDSLRLAVETLAPKGTFVTKIFRSKDYNALLYAFNQLFDKVEATKPAASRNTSAEIFVVCLGFKAPAKIDPRLLDSKILFQEVAEPKKVMGPEALLRQKIKQRRFREGYDEGFSTSQRITSALAFLVSDGPVEMLGNFTEMALEGPHSWVVAEGLGEGAAEPKELAAKIRSHAATTAEIRTLCKDLQVLGRSEFKQLLRWRLALRKDLKADLATEEEAAKGGHKKAKGADAKAGKDGEAGKEGEAVDPEEALMADMAALKDKMAREAKREKRKRREMKIKAKLRAAQAVQSEGLGEDPHQGGPEQLFNLKGVEAGLGDADVPDDDMMDVLEAGSDDEDSDAASGSDADSDMDSDLAYEMDLEDALDNSYKEYLERKGVRAAAERERRKRLGMEGELDEDDEGGAAADRSDDEDDDVERLEDDDGEDMEGGLLVSLDEDRAGVAKSGSAMAAQWFKQDLFADPNLLDDDDEEAGAGEDAADKRPAKKARTDGAEAAPAKGKKAVAAHAEEDEEPASARARSGLGAGTSAAALAGGKGRRGGADFEVVPQEPSGSGSGSGSDSGTDSEDEFDMLDDQGKAEVLALAKRMLRRKEKESIVDAAYNRFAFHDTGLPRWFAEDERRFMRPIPQVTKADIEAEKERLKAIDARPIKKIAEAKARKKQKLVKRLEQAKQKANVVADQEDVPMKSKMREIEKIYAKAHSSAKRKSKKGRKGPPLDKRLKKDKKSIKRAEQKMKKGGRKGKGKGR
The following text describes a protein:
Function:
A probable DEAD-box RNA helicase that plays a role in ribosomal 50S subunit assembly. May be a non-specific RNA helicase.
Sequence:
MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDVIAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELRAASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVLPEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVKHQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAKKMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRAGKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK
The following text describes a protein:
Function:
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
Subcellular Localization:
Nucleus.
Domain:
Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA (By similarity).
Sequence:
MADELDVVDIEGDECDEIVGDLSSAEILQDQYLQSAWRTNSSVLPWTLDSSISDENRQVIESMLLEEQYYFASKKAPKVAWTNEKTKVKKPLVKSSAAQTRWAEEEKELFEKGLAQFGRRWTKIAKLIGTRTVLQVKSYAKQYFKNKPKAEPAAEVTSANVTSVSSIQPHVSALTNAVRIERLSDDEDVDITDDFSDSELQSKKQPERSVSPDCNHHGELRPSLSDALLHLPSESTAADGQADPDFSEDTEIHHSEIDSEAVEESGNPFINLDSPSKHSLTGEEETELADKCESAECLEEEVEDQEEDEEEELRAPEQEVELDLNTITEEEKQAISEFFEGRPSKTPERYLKIRNYILDQWRRSKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFNCDQAIYNRPRLVDRSRLKESKDSLEAYHLAQRLQSMRTRKRRIRDVWGNWCDAKDLEGQTYEHLSAEELAIRREEMKKKGPRPSKLPKQRGSFDPFQLIPCKTFGEERQEPYSVIVCAEALIVMDIHAHVSMGEVIGLLGGTYEEEDKVLKICSAEPCNSLSTGLQCEMDPVSQTQASEVLGVKGLSVVGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAPFIGMIVSPYNPSNSSPQSQSTCLLVQEEPGPSGSHKFPYQFNMQCSAEPPDWSEVMRRAEWVVFKYRLCHGSVPMDRLFRRDSSLTCLEKMLLSIRTVLERLSEVDIETFLVQLESLFNTHFLSETGSSSTHLYETATQPQLLSFLSSEPISSSATEETSDGHDEPNTTGPDKLEQSCVEEEHDETVMQSTSAETV