lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli.
Subcellular Localization:
Nucleus.
Sequence:
MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPGGQLLESGCGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEEEGLPPMDLSNHLFFTAGGEAYLVAKLSLPGGSELLLPKGFPWGEAGIKEEPSLPFLAYPPPSHLTALHIQHGFDPIQGFSSSDQILSHDTSAPSPAACEERHGAFWSYQLAPNPPGDPKDGPMGNSGGNHVAVFWLCLLCRLGFSKPQAFMDHTQSHGVKLTPAQYQGLSGSPAVLQEGDEGCKALISFLEPKLPARPSSDIPLDNSSTVNMEANVAQTEDGPPEAEVQALILLDEEVMALSPPSPPTATWDPSPTQAKESPVAAGEAGPDWFPEGQEEDGGLCPPLNQSSPTSKEGGTLPAPVGSPEDPSDPPQPYRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPPEASLPPSAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLMGPGPPPPPGATPTSPPELFQYFGPQALGQPQTPLAGPGLRPDKPLEAQLLLNGFHHVGAPARKFPTSAPGSLSPDAHLPPSQLLGSSSDSLPTSPPPDDSLSLKVFRCLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGAMGTPSPASLGDGAPYGSVSPLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLLDMEGAEAGAELGLYHCLLCAWETPSRLAVLQHLRTPAHRDAQAQRRLQLLQNGPTTEEGLAALQSILSFSHGQLRTPGKAPVTPLAEPPTPEKDAQNKTEQLASEETENKTGPSRDSANQTTVYCCPYCSFLSPESSQVRAHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFTTKVLSAPTLSPLDNGQEPPTHGPEPTPSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDVAPPPTMAEEEEGTTGELRSAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSAPARGEAGAPPTTTAATDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEKKGPDTSGFISGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLTLAGPAPVLSLPAATPPPPPQPPKAELAEREWERPPMAKEGNEAGPSSPPDPLPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPEALGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPLAEPPKPPDGSLDSPVPHLGPPFLVPEPEAGGTRAPEERSRAGGHWPIEEEESSRGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGSMPTGGGTGGASGCRRCHATFSCVFELVRHLKKCYDDQTLEEEEEEAERGEEEEEVEEEEVEEEQGLEPPAGPEGPLPEPPDGEELSQAEATKAGGKEPEEKATPSPSPAHTCDQCAISFSSQDLLTSHRRLHFLPSLQPSAPPQLLDLPLLVFGERNPLVAATSPMPGPPLKRKHEDGSLSPTGSEAGGGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPSPAVKPPATATPASLPKFNLLLGKVDDGTGREAPKREAPAFPYPTATLASGPQPFLPPGKEATTPTPEPPLPLLPPPPPSEEEGPEEPPKASPESEACSLSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAAGSTGGSSEGLLAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAPPALKAPPATTPASMPLGAAPTLPRLAPVLLSGPALAQPPLGNLAPFNSGPAASSGLLGLATSVLPTTTVVQTAGPGRPLPQRPMPDQTNTSTAGTTDPVPGPPTEPLGDKVSSERKPVAGPTSSSNDALKNLKALKTTVPALLGGQFLPFPLPPAGGTAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPMIPQTLIGLLPNALLQPPPQPPEPTATAPPKPPELPAPGEGEAGEVDELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGGSMPPPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPQGGPPISITNAATAASAAVAFAKEEARLPHTDSNPKTTTTSTLLAL
The following text describes a protein:
Function:
Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MLAWLRHRIRSYNTSTYSSILPSASFGKVYKIGTKLNFTLLALCLLLACSVFFNYFYLADNNGLDIDTKGEEEENVFKDRKMVIFPNNFEITDKNLLEYYLKTLEEPLHPQDTIYRNRFIYKVPDVSYTSQTINLFSGLSQNSQSSKCEDLSSSYSFDVSGPQNKNCDLYKVLGKFLNDDSEYFQEISPLFPKLKEMLVKKEIEKHWFQLIGSSVWLEQYGVHLMTSRIFYSSTGDKVKPVVSLTYVQVFDHEWREIENVELIVPDGEGKYKPMTYPTFLPMSVYHNEKQQQGRFYGVEDPRITLVRNKLGYDEPIIVYNSHHRKITDAKSDNDGESNIHFKAYRSIFMAWLWQNQKGKNNVEEIETGKMKNRVYVKSKELIKPNNKREDKEKNWAPFINYQQRLQQGFDSHVYFMYQFQDLKILKCSLLDEEDCVWEYQFNDKNGAGRLRGGTELVNINQLLTTFDHPEIKRVKDLMPQNREIWIGVARAALEKCGCGDKMYRPNIVILIKDGDDQYRLSHVSPFVGLGIPILPWWPDKGLCDGKNLIIPNGISSWHLNKDEDNSVQDYLTLSISRADSTVDLLHIKGLLKSILFDDPNSKLLELNDYGFNNKNIECAVKSSDAFCKKYGSEYKLNNNKEEDKANGNGKGSSS
The following text describes a protein:
Function:
Probable transcription factor required to initiate organ founder cells in a lateral domain of shoot meristems. Involved in leaf formation.
Subcellular Localization:
Nucleus.
Sequence:
MASSNRHWPSMYRSSLACNFQQPQPQPDMNNGGKSSLMSSRCEENGGRNPEPRPRWNPRPEQIRILEGIFNSGMVNPPRDEIRRIRLQLQEYGPVGDANVFYWFQNRKSRTKHKLRAAGQLQPSGSGRSALQARACAPAPVTPPRNLQLAAAAPVAPPTSSSSSSSDRSSGSSSSKSVTVTPTTAVALASPAGAAPAAVFRQQGVMPTTAMDLLTPLPSSSAALAARQLYYQYHSQIMAPAAPPMPDTVIASPEQFLPQWQQGGQQHYYLPATELGGVLDGHSHHTHEPPAAIHRPVSLSPSVLFGLCNEALRQDYCADISVVPTKGLGHGHQFWNSTTCGSDMGNSNSKIDAVSAVIRDDEKSRLGLLHYYGLAGATTTAAAAVAPAPLAADAAAGTATLLPSSAASDQLQGLLDAAGLLMGETPPTPTATVVAVARDAVTCAATATAQFSVPASMRLDVRLAFGEAALLARHTGEAVPVDESGVTVEPLQQDTLYYVLMQATNN
The following text describes a protein:
Function:
May serve as docking site to facilitate the association of other proteins to the plasma membrane.
Miscellaneous:
MISCELLANEOUS: Heat stable and remains soluble at temperatures exceeding 90 degrees Celsius.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MPEEESIDIKFRLYDGSDIGPFRYSAASTVDFLKQRVVSDWPKGKTVVPKGINEVKLISSGKILENNKTVGQCKTPFGDIAGGVIVMHVVVQPSLAKSKTEKKVDKAPKAVICTCTIL
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAHPVCVECGASVPELVRDYGKGNLRLAICSACNAVADKYVEYETVLLFLEVLLLKPQVYRHVLCNLPAPVSLRTTLKLFVILVMLDMNVKAYLVDRDAGVTFRSESMYRSPDMSSSGARIGEFSLHLVCLALVENIVYFASVFAVIWMDPFRRGWRGKLLTSEEGLWAAWTKYGSAMCISSFGKLFALLTVIWEFHWSFVHVIGALVLVSNVLALQLLLGEGDPAQAKSLRVVAVVVVGLVARGAAQLALYAMGSSVLFHVLV
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MNSGIQLQAPKMPLLLKKSGDLIETSFKILFLCCAMAGVISVSTIGWFVFSEGLPALKEAGVISFVLGKEWLPPALYGILPMIIASLISTTGAIIIGVPIAIFTAIFLAELAPKWLANLVRPAVELLAGIPSVVYGFFGLVIIVPGIEAIFDIPAGNTLLAGIIVLAIMILPTIITISETSLRALPSVYKEGALALGASHIYTIFNVLVPAAKSGILTGVILGVARAIGETMAIIMVMGNAPAMPGSLLEPARTLTANIAMEMSYATGIHSSALYATGIVLLAFIVLLNGSLLYLNRKKAY
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MDNSPWFNQAATEMNGQNNDNNNAGNSRVDLTLKLGLPLFDSLQNPALYHNIQQGPVNEGAMAEAPQQHFNGSQYAAWLSPDQIGNSSSAHNMNYPNVFNNFSGPSVEFPPYDTINSYNYVPPPPPPPLHELPPNSYTLLDVPPRRAAQLQQREFESSSGWGLGRGQRGYGLYNDPNKRCTNYNCNTNDTPMWRKGPLGPKTLCNACGIKYRKEEEKRKTKEGRDGEQQFDLNE
The following text describes a protein:
Function:
Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall.
Sequence:
MVRIGSSLLLATLAATTVSAASDPPKCSQDSHCPEEWPCCSLYGQCGTGAYCLGGCDPLMSFSLDSCTPEPICQGKTYKDWSNLDNLASNTKYLGDASKSDWVYSGYPKVEDGNLLLTMPKNSVGTLIANNHYIWYGKITAKIKSSRGAGVVTGFILLSDTKDEIDYEFVGADLTNVQTNYYFQGVLDYNHGGNASVSGGNTFGDWHEYTIDWKPDAITWSVDGEVKRTLKKESTYNETSKQYMYPQTPSRMQLSLWPAGQASNAPGTIAWAGGEIDWDSEDIKDPGYYYATFGEITVECYDPPSGADIKGTKAYIFKDKAGLESSVQITNNKTVLASFGATGLDMDVGASSSASGSANKTSSSANTVPSGNGGSGNEPGNSHSGSSGSGTSTSDGSGSSTGFSQGSETSASSNKNAAPSQNERVLNGSFFAVLVAVVALVTL
The following text describes a protein:
Function:
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKSCSRSSSVRLCVRCTGLSLWCCIGHATSVIKSVRNMQSVIGNGYKRSPTGKESRMTPLTSDFLSSSVVFLSAAVIAVPLAQRAGLGSVLGYLLAGIAIGPWGLGLIRDVQAIMHFAEFGVVLLLFLIGLELNPKKLWNLRGPILGLGGAQVVVTTAVLSSVAYLLGVSWQSALVIGMALALSSTAIALRVIEEHGLTRTEAGQSGFAVLLFQDIAVIPMLALLPILAGNSSGDWLNALWMTGGIAALLLGGHFLLNPLFRYIALSGVRELFTVAALLLVVGIALLMQKVGLSMALGTFLAGVILAESEFRHELEIAIDPFKGLLLGLFFISVGMAVDVGLLLVKPLQIMLAVLGLVIVKGLVLYLLARLSGTVAKARSKMAAILSQGGEFAFVIFTAASAEGLLTASQVSFLLVVVSLSMVTTPLLLSAQKYWFARQLNIEENPLTPDVENKEPRVIIVGFGRFGQIVGRLLYANKIKVTILESDASQVRLLRKYGYKVFYGDATNLELLRAAGVEQAEALVVCTDDPEQVITIVELCQQHFPNLKLLARARSRVEAYQLMSLGVQNYTRETFLSALDLGRKALVQLGMHPYQAKRAEEHFHRLDKTMLKELLPQHNEDKQLELRAKEARTELEEIFSREMDSDQLSRRYWEKE
The following text describes a protein:
Function:
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
Sequence:
MSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQINDYYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLLEHTEGE
The following text describes a protein:
Function:
Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization. Protein produced from maternal transcripts that binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3. Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MQDPRHPQGLPLSPGLPKRQRQDRTIYNWKQQEVLENHFKEEQYPDYDTRQELAEMLNLREYQVQVWFKNRRAKRSRERWFQKQLQQLQKHPQQQHPQQQHPQQQLQQQQPQQQPQQQQPQQQPQQQQPQQQQLHQQPQ
The following text describes a protein:
Function:
[Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (Probable). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity); [Isoform 2]: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.
Subcellular Localization:
[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence:
MAPDPVAAKTPVQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYDISEFTRRHPGGSRVISHYAGQDATDPFVAFHSNKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVEQMGLMKANHVFFLLYLLHILLLDGAAWLTLWIFGTSFLPFLLCAVLLTAAQIQAGWLQHDLGHLSVFSTSKWNHLVHHFVIGHLKGVPASWWNHMHFQHHAKPNCFGKDPDINMHPFFFALGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALVPFFFQWYVFYFVIQRKKWVDLAWMITFYIRLLLTYVPLLGLKAFLGLYFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQLQATCNVHKSAFNDWFSGHLNFQIEHHLFPMMPRHNYHKVAPLVQSLCAKHGIEYQSKPLLSAFADIIHSLKESGQLWLDAYLHQ
The following text describes a protein:
Function:
Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.
Sequence:
MASSSSVADSIERLQDEVSCSICLEYLRDPVTIDCGHNFCTVCITDHCKRGADPTIGAALCPQCRAGFLLNNSRPNKQLANIVEGIERLALRPSKLSAGSEALCEKHGKKLRLFCQDDSEPICLVCDKSREHRMHTVLPIEEAAYDYKIKIQEAVALLKKVLEEAKKLEAQEEEKTAQWKEKVEECRVLIKSGFEKRRQAMAKEEQLLLRQLHEEEQVTVRVANKLGFPCWQCAGLQQLILEMEQKSQQPAAFFLKDVKNTLIRSEGISLQGLQPISMDLQESYDVPGLLESLRKYRVPITFDPDTANPYLHLSEDLLRVQVGDRKQDLPKNTSRFETCTCLMGCQKFTSGRHYWEVCVEGKTSWTLGVCQESVSRQGIFTPSPASGFWTVWLRNGDEYAALTSPLTELTLKTPPRIIGIFLDYDTGEVSFYNADSGSHLFTFADSFSGSLQPYFYPGVKAGGNDAPLIIIQPAGHEDNLVLSTTETFSGSYMPLSLAEDKFVSNS
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane.
Sequence:
MQQATEALNHPYFGVFVLLVFTFWVFNLTLRIQRFLSRKMAQKKGEKLKLAPYECGPVALKQPNRVSHHFYIMAMLFILFDVEIVFMFPWAIGFKKLGLFGLVEMLGFVFFLTIGFIYALKRNALSWQKLEVK
The following text describes a protein:
Function:
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression. Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation. Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway. In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor.
Subcellular Localization:
Secreted.
Sequence:
MPLLWLRGFLLASCWIIVRSSPTPGSEGHGAAPDCPSCALATLPKDGPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDMGDEAEEMGLKGERSELLLSEKVVDARKSTWHIFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEVDGDGKKKDGSDGGLEEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
The following text describes a protein:
Function:
Probable GTP-binding protein that may be involved in cell development.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAQIIDENAKVCETLEGYLDSIGITTAGLNYHTLSIIGPQSSGKSTLLNNLFHTTFETMNDQIGRQQTTKGIHAAFNNQNVLIFDIEGSDSRERGDADALFERKAALFGLALSEVVMVNMWEKDIGRYNASSIPLLRTVFEVNLQLFSSSQEAKCHLLFVIRDSTHPGEIIENQVRRDLDMIWKDVILPQNLQGKKFDDFFVFHFFQLPHLKLEPEKFKEQAAKLASMFTNKDEPGFFFAQPMGKLIPGDGLAQYIHSVWDAISENRELNLPSQRKTLSNFRCEEFANQAYKEFETNATEQIVSKIDAKPFTEFKEIGQKLFETAIHNYNQQANKYVRDIANEKRQSLQERISSFLAPSFQRNCTIFKESAEKKFTEYIEKLPTELEESNEWEQNANKKLEETIKSIDEFVKSTMIPEFKWQFDVSDIEDNLHTLITNKLDTAISEMEQRVFERRNIEYKERINAILDSAEPNMWERLRSEMRNEITQTTSEINNILKKNTVDRHPSPKIANMYYRSTDSQITSASQFIQQKMIIRFEEKFLQDEEHKSRVWKPDDDISAIFESARENGLHILNMFTNSQLREPGTPVPLNDILTRQILTQIRREQILTEFNDTIEKSYISAVQIRESLIVRNTVPLWMWIVIAIGGYQQLVSVVEHPWKTLFLLAAIGLVYWLWSNQKLDKVIKVVKNYITRVLCIIVKLLQSTTQEMEVAPSILQASKKSAANDMELIKKGLDDKKIEDEKTLETADTLDTMTTEVSESNSTSASTNSPSKSEDSKEPAPAPKPRHRKRVSTSNNPYATLQPNRINQAELLKMKEMIQKRQAEKH
The following text describes a protein:
Function:
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MGRRFVVTVRIRRTGRSPQVRVFLVQFLGSSRPRSANGTRGFVALVLRPERIARRGPQPHPGPGDDDGQRQSGSSPALLWCRFELRGPHHPLPTGARRSAGGLPRHSGSTAPGRGAAGCARCLGSPAARPGPRAGTSRRRAVFAVSTLLRWERFPGHRQA
The following text describes a protein:
Function:
Putative Notch ligand involved in the mediation of Notch signaling.
Subcellular Localization:
Cell projection. Cytoplasm, cytoskeleton. Membrane; Single-pass type I membrane protein.
Sequence:
MQFSILNHFHLKSTNGDGHFELDVISYVDPRGELADGSCCDPPSSSSSSSSADGIQECVNECDVAFRACLTNFQPRTTYDGRCVFGEGSTDVVGGNTLLSIVDGDIDTRSASVNSTPPAEKDTTIKFPFDFAWPTTFSLILEALDVDGNGVEKSQKPPSTKSSLPSSSSSSSPQQSHTPTMPFIIPMPIPVTTETASLTNAFETTTSTLGSRNVTFQLIERAYHSGILVPSSSWVALRHDGATATVLYRVRLQCDDDFYGKTCLNYCTPRNDQFGHYTCDDDGGRVCDHGWTGSHCMISICKKGCHATYGFCDSPDECRCRHGWQGELCDQCMPYPGCKHGGCVSPWQCNCEYKWGGLLCDQAQGACYSNPCMNDGQCEEVDHGFVCYCSPGWTGIACNSNIDDCLHSPCLNGGSCSDLVDGYECHCTSQWQGPVCQYDSNECTGQPCVHAFRCRNRFGDYLCDCQPGWTGRNCDVNANDCLGHCLNGATCMDLINSFICVCQPGYTGIECETNVDECSSDPCMHGGKCTDLINGYQCECKPGFSGTRCQYDVDLCNPNPCGHGANCFNLFGDYFCACPESHQGKNCSDAKTLCKGSLCQVIDSCTVTAGATSTGGPTQQPSNVCGPHGACISLDNNGGFSCICDTGYTGLYCHERIDYCESDPCQNGGTCINTVLSIQCVCTPGWEGLFCHISTDECSATPCRNNGTCVDLHADFTCVCPKRWMGKTCNSLESHCDSSTCRNNGVCEDAGQSFMCLCPPAWEGISCRIAIQDRCTGSPCENGATCIPSGESYTCICKDGFEGVNCEKNVDDCRLNPCHNGGKCVDGINWFLCQCADGFAGPSCRININECLSSPCAYGSTCVDGMASYTCHCPLGRNGTTCSQVIGYDPMPRSCQSGRHLRVHDETWQQDCNRCRCDDGHIVCSKIWCGPSSCLAVADETFSMYEPDDQSVFSCSQGFFCRPIQEHECFTPPCHPWGVCEKTASEASSDGYRQEHGYLTGRVDNLKDGRDLSLSVDHTGMIGCESGGNNDLSGTCIRLLLTFDLWIMPVGMTVEAVCNDIRQLPHIHDAAQDAAIFIICRKAPQETDTIDLTVSTDGNANAITANNVSQALISGLQGRSGNSPVVLNAITSIQQMSPSLVVSARFNARFLILAYMVVLVAISLFGCTVIAFGRRRHGCLNSQPPPPPPSLPLHVLTGSDQGIAESATTITTITTTMHQALNDYIIDENKTSDKSSTSRTSSSFRDDVHHYENDARRNQPTSTGYLVPDFERLNHSNKGSNRRVARRPRSRSEKEPT
The following text describes a protein:
Function:
Plays an integral role in secondary cell wall biosynthesis by the polymerization of cinnamyl alcohols into lignin and by forming rigid cross-links between cellulose, pectin, hydroxy-proline-rich glycoproteins, and lignin.
Sequence:
MTVIVGDSKEEKSPRLELNFYRNSCPNAEQVVKDEGCDGSVMLSYSNGSLTETESDMNFGVRKLDLIDGIKRSLERICRQTVSCADIIQLAARDGVHLAGGPYIEILTGRRDSKLSRKERADKQLPAADISVDKFIKLFQQKNITLQEGVALIGAHTLGIGHCRNFEKRLQPPGDPTLSTSFKLTLLVICSDPFLSNVTFATNDATTFAFDNRYFTDILNGRGLLKIDSEISSDQRTKPYVLGFASDQQQFFNSFTSGFLKLSNHKVLLGKEGEIRKDCRFVNN
The following text describes a protein:
Function:
GTPase-activating protein for Rac involved in streaming and development.
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein. Note=Accumulates in cortical regions of the cell and on phagosomes.
Domain:
The membrane association is mediated by the calponin-homology (CH) domain.
Sequence:
MQPKDYMSSSHANWENIQIDSFTSWINQHLSERGLSVKDLSVDFQDGVLLLNLLEILSGKKIARYVRSPKFLQHKIDNIMIAFNFMEKAFDIKVFGCNAKDIVDGNLKQTMGVIFLLIQKIKVNLHLDHLQEQQGETTGTTTTITSTNTTTTPTKPRFYRASMQVNAANRFSHISPNKDQSSSTVATTTTTSTSVVQPQPQPTTATPTTTTATTLTPPVASQQPVSTAPATVTPSTVIPTVTPLNTTTTTTTATSTSTNVPTATTNVPPTATTTTTGTRISPTTGVSVSTIRSKFLFEGGTGNTTGGNEKYNTYSPGSGNTSGVVGPSTSSSLNISSERVLKRTESGYLISGGLSLSGSGSGGIHEPLQRTVSLIEIKLNDHQSKFYDLKKIIFMQSVIRGYLVRSKWRNVLEKYKQHLNEYKKHFMNNKKAYRGLIRVQAIVKGKIQRKKLFKMFPLYRRNEIVKEILSTEDKYVTSLAMVTTHYLKPSEAFLSTQQVRSIFSQIEIIHRYNSLILEKLVSRNKIWYSSGQKIGDIFIEMSAFLKVYTIYVNNYNNSIQTITECMEIPKFASLLEKNRNQFGLDLSAFLIAPIQRIPRYILLLQDLLKNTKESHPDHQDLSLALKKMKDVAEYVNEKKREAENLNQVLTIQSSLTGKFNNLAEPHRRYVKKGTLISNDKIHLYFLFNDLLVKTENKIVSKIRDSARLSNNNSSDKNSKSTFHSPKEIINEGKSKYLNSYFLAGSSLVDSNPDGFTFQIIGVGDANELNSQINNQINNQNNNQNNNQNNNLNNNNDDSPILSFSPFSSSFASTITNSLSSIGNSNNVNNNNNTSSNSGFVNSSNNNINIVNSNGSSPLTNSGHGLNSSFGISSNNNNNLTMPTTSIQLEALSLNEKMTWMGELDECIFQLLEKSKSKKRSLITDADELTTVPFDISVVKDSEFSNVLEKKHSEISWRSKKFYLKNTHLYYHRYSSTESPKEPTKIKCINLILCSVKLAQVVDHPHCFQLITPSRIYFFSCEDSTVLFQWISLIRLSIKKKLESLKDENNNINNFTSIASATSPTSSSSNTTPIVVPIASHSNATGSLSASLGSSFLNQQQRSLEQQQHLNTSNSNLTPLALSSQVLYHINNFISTSTSTSASQSQSQSPSPSPSHSINQKQKIRKLSFYQSRSNTLININNDEDRLNSFPTSTLSVSCLLNNDNHGNNDFDGKSFTNNIDITTTTTTNDDNNNNTTTTQVKKGKDLSCSKELNCSISHDDNSKGSSGYGNNSCGDNINNDESNNNCAECGASDPSWVSINYGVVVCLDCSSIHKNLPEGNVKSVRSLSVAFSDIVKKQEGNIKANNKYEKNIPSGLTKPNPKDSYEIKLSWIKAKYINNNNNNNNSQNGDSTTPTPTPTSTTIHVNNDSTPTSPNLNSQSSPPPTATTTQTENVKLDNGRSSPTPTPTQTENNNNNVLTPTTTTTNTTTSTTTGSRPTTPTILNNEEEHIQGINLKDSTDTSNGKGTWSRGSSHAITERKTSFLDKPRVPVKKEHQGYLFKTSSPTSNNSSDWKKYLFVYKNDVLTYYKVSKKNKRKEKGIIDLFHSVKQESRPKQKYSFTLVTSQRLYFLASETEEEMKIWLDVLSSHTTH
The following text describes a protein:
Function:
Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.
Sequence:
MSSANYISDEVPPDMVSPHDHRPSKDEPLKHLDTVIALYDFPGTQSSHLPLNLGDTIHVLSKSATGWWDGVVMGNSGELQRGWFPHNYVRSVNYVQPVLKKLKDNKDLDSITAANTAANVVMPSLTNLIQKSLQESERNSPANSTRKNSVVSFASSETSMPSDSKYTQQQTNTNQNSPEYQSISLPSTRDHSTVEMQLPSQQSSISHTLTGFGIGDDEIIPMEVEEAEKLVEEYRLKYNKTVTWIPRTSTKGDIIFYCEQLDVYCESLPLILFDGEASSPNLEYPGSDVIMDPTPISVQGSQSMENVLDTREGSAAGSFDSTKRDSNVSMSTQSSGSSYHRFSRPFFSVDNLFYKHSSDIGTWNELKEQCNYILDLMLKAIKDQNRQFFSTHFSRLNKLVVALCAAVRLNQEDYIDTKYENTTRRKLKRVCASFAQIYINGILHLSVLHYSLEGFNEGRLFGYDMGKLNRSSSSSAFQSPASSLSTIRQGSDDSTRFAQKLSQDRNSEGNGDMNYINQLVYEIDNLRENVNSIVKIFLKLSANKKIKNSDYDSSDASDDEGEDRFDILPQVYPRFLVDEFNGGNWCNPFFSTKNTVLNVSGDDLKNRYHTKIIIDHSAYDSLSQYVDKIVDACENILEALDPKVQNTFYYNEMLRNERNTQILRLTYKSLYHCSAMVDLIESFDFTVFCSVKRHTGNAIDTEDESYENPSVWGDHYDSNLSFDYPVVLEFFRLKQELHDLVAKIIMATQSLTLEDPEVFKGLKEEDPLFYNREISKIPKEKAALLLSSILKEQLSFKDGGAISLNPDTLLSGYLVEIAKTTKTVLLITQQLIEERETIINYATRVMQDNFDVQLLLVERNNTSSSEKADDNSYYVGGHKKSTDVPWYLEGDDEYELLLDVKGNIKGGSKEALVSHLTHHLSLDSNFNAVFLLMFSSMMSLGELISLLIARFNIEPPEGLSYEEYNLWVSKKRNPIRLRVINIMKLLLEKNWSMSYYNEPVLRRWLTFAHSDQVQTYSLGNLLVNYLERLLRGERIYVERDPVIPNTKPPAPLTKGSSLSKKPRVMDIDYVELARQLTLREFKLYCKITKFACLAKVWGKKSGLSESIDSITQFIKASNQLTNFVGYMILRKADPKKRVQIIRYFIQVADKCRQYNNFSSMTAIISALYSSPIHRLKKTWEYMNADALSNLKNMNKLMNSSRNFNEYRDVLKFIGSEPCVPFFGVYLSDLTFVYHGNPDYLYNRTRQVNFAKRAKTSEIVSGIDRFKTTGYNFQEVPEIQKFLDAWFEKCPTIDEQYQISLNLEPREQAVGASNSNSTTNATTNIKSFKPFSLK