lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus.
Sequence:
MDGARWSEVYPSNIMGCKMSTLQLQIQLEMKKTADVSDLWIQHQRRNTKTTQSWSCIFCLERKICLSETDLWNHAEKDHRDKFPTDQDELKRFRKYYESESALKRTTKDDSQPRKPSNIETPAAGSTTPTLHLQSKRPLNSTQPSRSLSSLQALNLGPNEGNTMEDEETTAYKPRKRAAVGDGISAGSASPFREESESPPPRRSLARPTSGQIPVSDTETRRQATKGQLWTPDQDSPFTRSSFDPSNIASTQASKSRAQMFKPANRRPLKTSTPQTSSRPALHANQQPQQQHHTQANTPSVILPNRTVSETESRSQSEEYSIILQPETRPISQDQLVAEVKGIYAGLVMVEAKCIEVDNKQATLTQGNPPTQPKLNNEQWQALIALHRTLLHEHHDFFLASQHPSASAPLRRLASKYAMPARMWRHGIHSFLELLRHRLPASLDHMLAFIYLAYSMMALLYETVPAFEDTWIECLGDLGRYRMAIEDDDIRDREVWTGVARHWYSKASDKAPTTGRLYHHLAILARPNALQQLYYYAKSLCVVVPFTSARESILTLFDPVLNAENGQGQYRLPPLDTAFIRAHGHLFTNRTMERFEPAVQEFLALLDSHIGRVTKKFMEQGCHIAVSNNVAMLGFASKENPLMKAIAPSSEEKAADADMDDALDESSPSMTTFKHAQNLSNAALEIVLQRIGDPNVLPFIHVSLVFMFRRIEDKKFPLPEKDDVRPFPEDFGIRGLLWAEKYFPEKWFLNEKTDEEEKYHELPSMFEQRKERILWLACRIADAGPWINFDVSKPEFSVQSSDADLEFMESQSVTFASASTNDANRSWPSVKAYPDAEEDITSLTMLAANTSTHE
The following text describes a protein:
Function:
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MRNLLLVAAVALSTAGCGIIYKQPIYQGNLIKQTAVEQLQVGQSKQQVSALLGTPSIPDPFHAQRWDYTSTQRVDRLARTDVKNFTVFFENEQVVRWEGDYFPAQDEQLAKSAPKQFGRNLARDKKKQRGR
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. Probably unwinds dsDNA templates, thus providing substrates for CRISPR-associated endonuclease Cas3-HD. Unwinding is strongly increased in the presence of ATP, implying the helicase uses ATP to unwind substrate.
Domain:
Proteins of this family have an N-terminal nuclease domain and a C-terminal helicase/ATPase domain. In some CRISPR/Cas systems the domains are swapped, in others they are encoded separately.
Sequence:
MDIINFFKQITDHEPYDYQIRAWEKINKIMELGGRVVIEIPTAGGKTEAAIIPYLYQFISNDWKVPRLIYVLPTRSLVEKQVERIRNYIKKILEIKGYSKDKVEELAKKIVQVEYGLEETHAFLGFVVLTTWDTFLYGLAAHRTVGDRFTFPCGAIAQSLVVFDEIQMYQDESLYMPRLIGLVVKRLVEANVPLVFMTATLPTELKKILGIHDEEPITVNPEDTKKPERGEVVVEFKEKLSDEELSNEIKKAINEGKKVLIIKNTVNSAIEVYEKVKQLGNSLLLHSRFTVEDRAEKEKDIDKAEIIVATQVVEAGLDLTNVGLVITDLAPLDALIQRIGRCARRKGERGKVIVVLPNFNEKINEDHREKVILGFKNIPFENAYVTLVNNKDYGRVIELTIETIEEKKGKSKIVPKKFYIGDLGNKTIRKLIENNKILKKKDLYFIPYSTQPYDPLIMIKSFDEVESVSEYLYDIIKAREALDRVYKEYYENNIVPKDYYSAYIYFRELKLFSTPPEYELKARPEMFAILYPLENAEEKVKNKEIIEFNPKYVIRVSYNWLKNKWEKFDKKFELIKEYDEKGWICSLKKAGKLQPYKIYIIDDKYYSKETGIII
The following text describes a protein:
Function:
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVLVSNDDGVDAPGIKILADALRNAGHEVMVVAPDRDRSGASNSLTLDTPIRAKQIDMHTYSVAGTPTDCVHLALTGLLNYDPDIVVSGINNTGNLGDDVIYSGTVSAAMEGRFLGLPAVAVSLVTLYREGQQAPQYETAAHAAINIVAQLKTDPLPADTILNVNVPDVTWQQMRGFKVTRLGNRHRSAPCLTQTDPRGHTIYWIGPAGPEQDAGPGTDFDAVRNTYISITPIHVDLTRYQALENVTRWTDRLTAHMDWPT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MEGEGDSRVHFSEVSDPWSSSRHVEVLQALDSVEKKLVTALRTAATAMSLMAPRVSSEESSSLAFNSACTEFLQLVKEIHTELANHIHLVSDYRTFARSTYGAEKDVEISREKVKVVSEQLQTLSRFLEDHYTPEES
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSCGDNDTQEQEQLMPRRRQVRRVDKSICQKCRQTKSMYIIRNVTFCKTCFEAAVFSRFTKSLHPPLKSPTSSRSAASSGYRPPAQSGSALIALSTGCGSTTLLDLLLTRRYIGKGDDRVVDKTKGEKEPVWRKGWVCYVDFSSVVGEIERQGEGQGQREGSRMEEVKKWVEGRENGLGWVGLRAEDVFDRGLRNRLRLLAGLPIRDDKQEVAAQWAVDLKDHALPLSSPSSSSSPSPTPLTHLRNLLSSLPPSSRPQLLSHILSSLLTTVAHTLPHISHVLMGETSTRQAERLISGTALGRGWQLPLELAAVRAEPALSSLEHLITSAEAEAEGENKENIGFTWLKPMSDLTAKEAAIYCHLRSLSSFTYNARHWDSAGPPPAAGKTKGGVKSLEMLTENFIAGLGASHPATVSTINRTGAKLVFPGKEEDRPYCPVCQMPVDPSALEWKSRTALTFLSTKTEPTAISKQQQPQHGETEALAPLLCYSCLTTLTPPTVVSKAKAKAQTAGLTVNGDEPVLLPVWVNEGVKRRQMGRREMKDEIKEFLIEE
The following text describes a protein:
Function:
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). May be involved in the biosynthesis of menaquinone (By similarity).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MRALHVPAGSATALLLPALQRVLGGSDPALVAVPTQHESLLGALRVGEQIDDDVALVVTTSGTTGPPKGAMLTAAALTASASAAHDRLGGPGSWLLAVPPYHIAGLAVLVRSVIAGSVPVELNVSAGFDVTELPNAIKRLGSGRRYTSLVAAQLAKALTDPAATAALAELDAVLIGGGPAPRPILDAAAAAGITVVRTYGMSETSGGCVYDGVPLDGVRLRVLAGGRIAIGGATLAKGYRNPVSPDPFAEPGWFHTDDLGALESGDSGVLTVLGRADEAISTGGFTVLPQPVEAALGTHPAVRDCAVFGLADDRLGQRVVAAIVVGDGCPPPTLEALRAHVARTLDVTAAPRELHVVNVLPRRGIGKVDRAALVRRFAGEADQ
The following text describes a protein:
Function:
Regulates cell-type differentiation and spatial patterning, required for the proper induction and maintenance of prespore cell differentiation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Note=Localized predominantly at the periphery of the cells, possibly in the cortex or the plasma membrane.
Sequence:
MSWLNNPSQNFVDPFIRIKCILGDDIRIIKFNSNISYGGLMNQLEQDFQCPISIHQYEDYEGDKVTVKSKDDIMEALTMYFELKALNPTKIISTKFFLKQLPPQSQPLSSSLSPTQSLILNNNNNNNNNNNNNNNNNNNNNNNNIIQHTDFPSLIINEHEELISNHNIKWQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQSFLSVFLEYIPGGSISSLLGKFGAFSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSKSFSGIVSQFKSMQGTPYWMAPEVIKQTGHGRSSDIWSLGCVIVEMATAQPPWSNITELAAVMYHIASSNSIPNIPSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFIMNLDDNIQLPTISPTTTLSTNTTNTTATTTTTNNATNSNINQQQQQQQQQPPTRTQRVSISAGSSNNKRYTPPISTSTSSSSSSILNNFSINIILPINLIILIFREIKPNFVNTLSRVCKHWKQIIDDDELWNKYCSDRLINKSKFEESITWKSNYIKIYKQQKVWFHNKLNHSTLKGHDKGVFCVKLIDDQGMVLSGGEDKKLKVWDISGNHHHNHHSGIVGSISKKSGLNIINNNNSNNSNSSSNSSSSNSRYLFSLKGHSGCIKSVDYQRQSGSDVSRVFTASADFTCKIFSLKTKKTLFTYTNHQEAVTCINYLGDVENKCITSSLDKTIQLWDAETGSCLSTLRGHTGGIYCVKTDQVATHGNGYNHLVVSASVDKTSNVWDTRSSSKVRSFTQHTEDVLCCYVFDQKVVTGSCDGTIKLWDIGTGKTISTFIPSETRQKNYVWTVQFDQSKIISSGKTGIIRIWDIYNERDSRSIGGHHETIFSLQFNNQKLITGSLDKLVKIWSID
The following text describes a protein:
Function:
Chloroplast chaperone required for RuBisCo complex biogenesis and translational regulation of the RuBisCo large subunit (RbcL). Stabilizes an end-state assembly intermediate of eight RbcL subunits until the small subunits (RBCSs) become available to produce a complete stable RuBisCo complex containing eight small and eight large subunits (By similarity). Involved in the differentiation of bundle sheath cells, especially chloroplast structure.
Subcellular Localization:
Plastid, chloroplast stroma. Note=Associates with chloroplastic polysomes.
Sequence:
MAATASLTTTAPSPPALLKASAPLLISFRPVSRHCKNLCIKTKATENDQSAKKHQKVKSILCQDCEGNGAIVCTKCEGNGVNSVDYFEGRFKAGSLCWLCRGKREILCGNCNGAGFLGGFLSTFDETAQ
The following text describes a protein:
Function:
Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.
Subcellular Localization:
Vacuole.
Sequence:
MLFAVLVVAVLSTPFYSPHLLKYLNKKENKLWEAGIPAKFANRTHDEVTKMFFPHAFLRPNIPRYYGVNITEDDLYPPAGSPDRLDYRQTHPECFFEPEDQKECSCCYAFATLGALSTRRCIAKLDPQAVSLSVQHMVSCDSGEAGCQGGEFESSWAFLETEGAVKSDCLPYTSGETGKSGECPTTCQDGTPVESAFHYKAASASRLSNYNEIMVSLLADGPVQTGFYVHEDFLYYVGGIYHKVYGTSLGGHAVLIVGYGSMNNHDYWIVRNSWGSDWGENGYFRILRGTNECGIEKNAWQVAVK
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MAAAEEEDGVPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFNTHEPFRRGTDTLFSSPVPCLPLSP
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
VEAEEAPEEEIATEVQPEVKEKKKKKKKKVVEENEEGEEENGEGTKQEEDYQKEFKVLGHHDFTEVKKIRVVSGWIKNAREFPAGIDSDNLGPLAEITPHLPKSLVKRIEAELKHWFPVQRAVIPELLDSIVNPPVLRRRDLAISAPTGSGKTLCYVLPILATISNPGEFISTLIVVPVQALVKQIINEIGRFNGIGAKVVGLSGSDPYDKERRRLINAEGLIDADIIVATPSRFMEHFLDPSASFDLSRLRYIIADEADRMLNVRQEWLELVEGESGGLGGATSIMDLATKRNSPQKILLSATLSRDIEQLEKWNLHRPRLFRASAEKAEQVDTSAECVLPSGISHLILETPLKFHPLVLFNDIIESECKRILVFTNHKDSSVRLCKLLSILSDGSFQVEQLTADLFGKRRHKVLDRFRKGTTRVLICSDYLSRGVDVEGIDCVVNYDLPQATRLFIHRAGRTARAGTKGRLVSITEKEPKRLYVKLLKKGNLWNDASEKKIEEEELEESKEKYTKALEKMKKEMEEETKKDGGKEEKKEKENGNGGRGGGAMMRGGSRGRGNGNRGGGGRGGGGGMGQRNGKRNGT
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/mutY triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo-dGTP). This suggests that MutSL also functions to repair mismatches due to oxidative stress in both growing and stationary phase cells.
Sequence:
MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIEIDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPSIASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYMKTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAKKMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLPIGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSAQVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPPLQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQHKQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREEAAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFKRVM
The following text describes a protein:
Function:
Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEPRQLFSDPTADPISTAGAASNALSCASFNLPEGGILQLPNGEIITLSAPAAFKPPSCNLALRSVPNIIASGGVVGGTASGTMGLKADDDSHFSDWRDPFYASTFPQCYALAATTIIAYTLVIMLFITPRSFLDGGVVVLGRKGFTNGGGGTSIGGRPWLQKVAALSVAISLTIANAATFRAAEQQYSWGVQNAKQLQEDVLGGAELKIIRIISDTFLWLAQAQTLIRLFPRQREKVIIKWTAFALITLDVIFQSLNSFKYGGSDLTRPKFTEAVPALSYLFALALGVLYAAWVLYYSIMKKRYAFYHPLMKNMILVAVLSVVSILVPVVFFILDISKPDFAGWGDYVRWVGAAAASVIVWEWVERIEALEREEKKDGILGREVFDGDEMLEASQSEHAWPKMKRKGSGGSDSQDTESGGGGKDGGPSLSRFGAWSKISTLTSKHRTEPSSRNEPNEGSSPVAETTNDDERPRFLSPPLWPARPTPAATPVSRTDTTSAASTMYAVRYHTMTELTSYGTPPPTRNMGRLSGSESRGSSRHRDYGSASPGSAPAQDARSTQNSHVGAKASSAGSRWHALTPTVSSRDFVTRSEPRSSKMQRDENSRWDLRARVEEFAATQAENLREKFRPTLDTNNLPVTVIPAPPRRGAAIAQLCEEEELNHSSREGTVREESRNSNASGTVIAVGGAQTPIQTSFSPPPRAANSSMSTAQMPRPQLSPIVTQGSFTNNRYNHLPVTVIPAPPRQDPARAPSQPQSPSLVALGKQPARSDSSTTPSP
The following text describes a protein:
Function:
Transcription factor. Represses gene expression, probably via binding to DNA consensus sequence 5'-[AT][CT]TTCC[AC][AG]-3' in promoter regions. May play a role in pharynx morphogenesis.
Sequence:
MNCESLLTALDVSTLLSTLSSPEKEHRRKRRRGEVANPSNTLDALVARKADDQPFEKRYLSEQEAIEGPDDEIEMKKMELDPDVSTRTCSTCGYQGKWVSEMIRHKRVHTSERPFKCRYCSRTSKWKADLIRHVAKTHGIRVVSKYSRSKVFDATNSSMDSSCSSDSDRCIISEKRTVFYRCQLCSFEDERVSVLNSHVSHLHNTSPCVCRCGAKFEDVQGALAHSNGPCSHVDMIYNVMPTYEKASPLSPCRSESSSDSGIQTDPEEEASIITSSLPTPQLGSSPLLLSPTLPVTPSFLPDIQSALLSLQPNPLMSLYLASLLQSSLLNSPTIPTSFPQIIPTTILTPSQQDEMVDVEM
The following text describes a protein:
Function:
Involved in the control of the cell shape. Target of the inhibitor staurosporine.
Subcellular Localization:
Cytoplasm.
Sequence:
MVQLDDALQDAYKKVEREESLILGAKAMVASTKNPEVKRRLESNIAVSENNIKYLRERIDALKVESGSERESQSDKDSSKKYSDSAKSTNSDDHLLSYNRSAFDLFNSEKPLSPEKISTMLQHLQMRLSIEQQCVSGIEKIMSLYSKEQKDKTDVIIKLKEGKQKVNLLKRSLKRYNELHIPFDISTPSSEEKQQASGLNFRGLAKPISGTLKVTIHSLRNIEHTSFLQTHSFTMPSYAVLYVDDAQVAKSRISQTDTWDETFIFDVHRAKEFQIIIYEKKKDFDIPIALILIPTTIIAEELRRKRNIQEMSETSWKPSIAESASRSDEKGSKSDPINAPNSSSSISTNSPLAPTAYYKLLSKSWLSLEPVGQICISLSFSKRTTKRQFPETGLGRQGAIRQKKEDVVASQVGHQFVQRQFYQIMRCAVCAELFSYSPGLQCENCSFVCHKKCVTKVLASCIAQSNSEKSDFGGLRYRIPHRFEPFNSLGAQWCAHCGFFLPLRRKDCFKCVECGITCHGQCAHLIPDYCGMSNDLKHQLLTELEVSKRPKKPELPNQENKTTNEKVYRKPLSSQNTFDTLPTISQGLLAATQPVTSVLNTSPLPKTPEKDRSLNVTPSSSTPTPASVLAPPSSASLSSSKDANRSVPESPRREKKNRVTLDDFTFLAVLGKGNFGKVMLAEYKVNKKFYAIKVLKKEAILKNEELESLKTEKHVFEVANKEKHPFLLNLFASFQTSTRVYFVMEYILGGDLMVHIQRQQFSVKRARFYGAEVCLALKYFHENGIAYRDLKLDNILLCPDGHIRIADYGLCKENMLLGNTTSTFCGTPEFMAPEILLEQQYSKDVDWWAFGVLMYQMLLGQSPFKGEDEEEIFDAILSDEPLFPINMPADAVSLLRGLLTRDPNQRLGSGPKDANEVMAHPFFASIVWDDLYNKLYEPSYKPLINDPRDLNNFDEEFTSACPTLTPVNTVLTRQQQECFRGFSSFATE
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MGRRKIKMEMVQDMNTRQVTFSKRRTGLFKKASELATLCNAELGIVVFSPGGKPFSYGKPNLDSVAERFMREYDDSDSGDEEKSGNYRPKLKRLSERLDLLNQEVEAEKERGEKSQEKLESAGDERFKESIETLTLDELNEYKDRLQTVHGRIEGQVNHLQASSCLMLLSRK
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.
Subcellular Localization:
Nucleus.
Sequence:
MDIDQFLNDPSEDALRPKNSNTPEVDLQALTRAWINERGAPEILPWPPNNLVERVTERIKKQIEKVEELTGDMDPKTNFGLICIQTELERWKYLIRGLVRARIAKIDAHTLHYLSNEGLRSRLSETEIAYATRHQQLLHSHYLSSFLGSFPATLQNLNDQAGGISMISGPDEDTAVFARGTGSYEEFTGDGGSISVLGRGRDGDDVKDVGRGEVVIARWSDVREHVEKGEMELV
The following text describes a protein:
Function:
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Domain:
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence:
MHSADLTSHTDVTETTNLAAIEQLKEQRFNEKNLIIYNPPGENDELSARFLRSLAFATFKRRSPAFLRDLITFLQDREADIIEQCGDYAHFDLKRTIWSLELLRDDIINNREFQIIRVKSPDTDSWNSFLKGLGEDRRQWFSAIWLHADCYMYRRIWSIFQRSETLKNYDYFGDQKTSIVTNVAPLMRDILVSTKGIKRSQEDFQYLLKLSTWSNHGDLNITRRGAHDKIYKQIAKYDIDLLADQSFDVWQDLIEASAPVYVDIVCDNAGFELFADLLLGEYIIESGLASRVRFHVKAIPWFISDCTHKDFNWLVKFLRKHEFQELNAFGKRIRGYIRDRSFILCDKSYFWTSGHDYSQMKRVQPCLYVYISQASLVIFKGDLNYRKLLGDINNKPTTQFSDCLRGFQPSSVCALRVIKSDIYCGLPICTVEKLSEENPEWMVTGDKAVVQVAIKHRLSSDIIV
The following text describes a protein:
Function:
Decarboxylase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC. The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC. The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone. The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodin anthrone to emodin. Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin. Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity). Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH. Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin. Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death. The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway.
Sequence:
MGESSRKPSRYLCLTICGYRKPGMSEEDYRRYMTEVSAPMTKDLMVKYGVKRWTMVHNTTATRALMAELCDSQMTNVVDFDCFSQVVFESLEDYKRMKQDPWYKEHLFHDHENFADTKKSMMTIGWIEEFVRQGVAVDGMDN
The following text describes a protein:
Function:
Putative serine protease.
Sequence:
MMNFLRRAVSSSKRSELIRIISVATATSGILYASTNPDARTRVSLAIPESVRESLSLLPWQISPGLIHRPEQSLFGNFVFSSRVSPKSEAPINDEKGVSVEASDSSSKPSNGYLGRDTIANAAARIGPAVVNLSVPQGFHGISMGKSIGSGTIIDADGTILTCAHVVVDFQNIRHSSKGRVDVTLQDGRTFEGVVVNADLQSDIALVKIKSKTPLPTAKLGFSSKLRPGDWVIAVGCPLSLQNTVTAGIVSCVDRKSSDLGLGGKHREYLQTDCSINAGNSGGPLVNLDGEVIGVNIMKVLAADGLGFSVPIDSVSKIIEHFKKSGRVIRPWIGLKMVELNNLIVAQLKERDPMFPDVERGVLVPTVIPGSPADRAGFKPGDVVVRFDGKPVIEIMDDRVGKRMQVVVERSNKERVTLEVIPEEANPDM
The following text describes a protein:
Function:
Transcriptional regulator.
Sequence:
MRTMEKEKNSLMRFSVSLQKNLLDNLDARLTNQGYASRSEVIRDLIREKIVQESWEKDDNSEDKVAVFVIVYDHHQRELNQRMIDIQHSADTEILCTTHVHLDHHNCLETIIFRGKSADIHQIALEIAGLKGVKFSKLTQTGHFPKDL
The following text describes a protein:
Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSDSQTPSMGQIAAYRAMKFAEESRESCWKRSVVACVAGAAMGVGLGTFLGTFEGAHGDLVGRNMREQLVNGFSKSIKAGYVRSVYFSKEFALVGSIFAGVECVIERERAAHDILNPLLAGGVSGGALGAWAARSSGAKLLVQNTAKGAAGFAVMAVVFEKGIEFMTN
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MFETIAFYFFAILTLSMALVVITTTNILYAITALASSMVFISAFFFLLDAEFLGVVQITVYVGAVIVMYAFGMMFFNSAAEVVERKQSPKILCILSFGVALLLTLILSAPSIGENLSNQVNSNAIDAQIPNIKAIGYVLFTNYLIPFEAAALMLLVAMVGGIATGIQKIHGKNHTQFIKESL
The following text describes a protein:
Function:
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Sequence:
MRKMKRLTWDETKITAFQEALVSWYEANKRVLPWRENTEPYRIWVSEIMLQQTKVDTVIPYFNRFMTQFPTMESFVNADEADILKAWEGLGYYSRVRNLQTAMKQVMADFSGEVPTDLTTILSLKGVGPYTAGAILSIAYNQAEPAVDGNVMRVIARVLEIGEDIMKASTRKIFEEVLYQLIDKKNPAAFNQGLMEIGALVCTPTKPMCMLCPLQPFCEAHKNGVETNYPVKIKKVKMKTKELLSIIVISEDGKIAIEKRPENGLLANMWQFPTIEISKKENDEVAKLQFLHNYGLEVLLEDEPIAHIKHVFSHLVWKMDIRVAKLQSAIPNENWYFATEEEMKRLAFPVPYQKMWQAWKDFKGE
The following text describes a protein:
Function:
Involved in pre-mRNA splicing and cell cycle progression.
Subcellular Localization:
Nucleus.
Sequence:
MNDSNDVLVDVSLIEAKDEPFELELLRNPFSLKAWLRYLTANESSSFLKRVFLYERACNDLPGSYKLWKQYLELRIQHITQVPVFGFVDDYEAVNNCFRKALVLLHRFPVIWEMYLKFLMLQANVTDTRKAFDEALRALPVAQHDRIWELYKDYAISIGGPFCVHVLRRYVCVEPRAIEDFIEELVHMEMWNDAVHEYLNILNRPVFLSTKRKSNYQIWSEFSELLVKHPREIQNINVEEVLRAGIKRFTDQAGRLYTTLARYFIRMGLYEKARDIFMEGITTVVTVRDFTFVFDAAVEFEEQWVTHLMERAETNNVNDVELDFQLLRLENLLNQRPFYVNDVLLRQNVHNASEWQRRVELHGEDAEAVLSVYTKALSSIKPSQAVGDFVGLWTNFAMFFEKLDDLENARIIFEKATKVPFKSVNDLAQIWIDWAEMELRQNNFDRARSLVAQATKGPKHSTVSFFDESLSPQARLHKSAKLWLFYLDLEESVGTLESTRALYERMFELKIATPQVVVNYANLLEENQFFEDSFKVYERGVALFSYPVAFELWNLYLTKFVQRYKGQRLERARDLFEQALDNCPEKFAKPLYLLYAEYEETYGKARKSLSILEKASTAVVPEERKNVFDIWLVKATVNFGIAAARPIYEKAIEILPDAQVKEMCLRYAELEIKLGEIDRARAIFIHGSQYCDPRVESDYWEKWQDFEIKYGNAEETVKDMLRIKRSVLAKFNSDVAFIAKQAAVLSTSSDAVASNDAMEQLNNAVVRDKPLAGFVASSTGPQGGNVNDQSPSKQASPANPEEISLDI
The following text describes a protein:
Function:
Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin (By similarity). Does not seem to be involved in actin-based lamella protrusion during cell migration.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MAVSFEKNRAQIVAAWKDVLDDKSDTNWSLFGYEGQTNELKVVATGDGGVDELNEDLNSGKIMYAFVRIEDPKTGLNKYLLINWQGEGAPVLRKGTCANHIRDVSNLLSGAHLTINARNEDDIDLDRLLKKLSTVSSAYSFKEPRGAMEEQKAPVGTNYTRVIPTKELNASVMQDFWKKEEAEEKLRQEAEKESKRLELQKLEQEQRSREEKEHKEREKLVISTTKLQPAHVPIKTSPQPLSPEKTAPGFANNLTDAERMRQARNQEARELIGSRVGAAKAMFTKHTSEGQLQSKLNTQPPAKPARNSIAQRINVFNQNQPQDAPVPSPPRAASPAKPLPVEAPEPVVPAPAIAPAAPVAAEVVSTIAEVEESQPVDDLPLAHESEQFSTIKRSPHSKSNSLQSQSPDETTSSNETDTAVSQEQEEEVRTKVSVTVQQSQSVKSSGMSTLERNALTDLVNEDDFICQETLGDLGQRARALYDYQAADETEITFDPGDVITHIDQIDEGWWQGLGPDGTYGLFPANYVEIIN
The following text describes a protein:
Function:
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular Localization:
Membrane; Single-pass membrane protein. Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Sequence:
MTIDRTYPIFTVRWLAIHGLAVPTVFFLGSISAMRFIQR
The following text describes a protein:
Function:
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
Miscellaneous:
MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MSNFGRRTWDREEYAEQARSGYDDRSLKATLTPIELQALKSKYTNYDHLIKGSLKDLNKRKLTANTESLSSFKRGKKFGFYCDICNLTFKDTLQYIDHLNHKVHAIKFENLFDEPLIIDIRDNDDVPQEEFELCYHNLIKDFVEVRSMETQSKRKRLLDTDVEKAKKVATKPSIESESKVSQMMGFSNFATSKK
The following text describes a protein:
Function:
May be involved in sterol transfer between intracellular membranes.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes to intracellular puncta representing endoplasmic reticulum (ER)-mitochondrion membrane contact sites, nucleus-vacuole junctions (NVJ) and other non-NVJ ER-vacuole contact sites.
Domain:
The VASt domain bind sterols.
Sequence:
MSDVDNWEPVSDNEDSTDSVKQLGPPFEHASNNDNAGDTEAESLQEVPLNTETNDVRKNLVVITNQSAADEHPTEIKHDQSRTSSTSSFFSGMISSFKSNVPSPVSRSTTPTSPVSQPSIISHRREPSMGSKRRSSRRISNATIAEIGSPLQQVEKPDEVKTRLTPSQMKEDNYDHRRFVEERYMDTPYHYASEQRNKDFHETFKSVPKDDRLLDDFNCGLNRELLYQGKLYITETHLCFNSNVLGWIAKVLIAFEDVTFMEKTSAAGLFPSAISIETKMGKTLFNGFISRDAAFGLMKEVWSRTLLQKDMASENINTKAEKSGNGKEIDDAINSIDEENNDKDANDNDTNENDDENISTNETTPNSTSSSPDKEKEKAYKLRADSSYQYDGPIYHHSTSFPAEPMANNEFVLKELPFDCAPGILFEIMFNSEQNEFLLDFLRGQEGSQITTIPNFTSIDGSSMTLKREYSYEKALHFPAGPKSTTCYVAEVIKRKDPDTYYEVISSIRTPNVPSGGSFSTKTRYLIRWNDEITCLLRVSFWVEWTGSSWIKGMVENGCKNGQLEAAQLMERILSKFIKNNVEECQITISKEEEEQDDKEVKNKLKEVDLEQPREAVVTAPAIAEQQGLKVTMETWLFLYLIVVVLLLFNLFYIRSIAVSLHQLVKLQLVELKL