lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with AceAa, they could catalyze the formation of succinate and glyoxylate from isocitrate.
Sequence:
MTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA
The following text describes a protein:
Function:
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Required for normal cell morphogenesis, cell wall synthesis, and actin organization.
Subcellular Localization:
Vacuole membrane; Peripheral membrane protein. Golgi apparatus.
Domain:
The phosphatase catalytic core motif (or RXNCXDCLDRTN motif) from the SAC domain is found in metal-independent protein phosphatases and inositol polyphosphate phosphatases.
Sequence:
MAKSENSTTSTFSSFANKIQPSNDAESDPDSYALEKFKLYETRARFYLVGSDRNKRFFRVLKIDRSEPSELNISEDPVVYSPQEIKSLLQRIAEGNRATGGLAFVAKVYGIAGCAKFMESYYLVLVTKRRQIGCICGHAIYAIDESQMISVPHATIQSDVANSKTELRYKKLLSSVDLTKDFFYSYTYPIMQSLQKNVLSSGEEGMPYDNIFVWNSYLTQPIRSRCNNTIWTLALVHGHFKQIRLSIYGRDFSVTLVSRRSRHFAGTRYLKRGVNDRGRVANDVETEQLVLDDEAGSCKGKMSSVVQMRGSIPLFWSQEASRFSPKPDIFLQRYDPTYESTKMHFEDLVNRYGNPIIVLNLIKTVEKRPREMVLRREFANAVGYLNSIFREENHLKFIHWDFHKFAKSKSANVLAVLGAVASEALDLTGLYFSGKPKIVKKKASQLSHANTAREPSLRDLRAYSAELSRGESANDILSALANREKEMKLTQQKKDEGTNSSAPRYQSGVLRTNCIDCLDRTNVAQYAYGLAALGRQLHAMGLSDTPKIDPDSSIAAALMDMYQSMGDALAQQYGGSAAHNTVFPERQGKWKATTQSREFLKSIKRYYSNTYTDGEKQDAINLFLGYFQPQEGKPALWELDSDYYLHVSGIGDDIFPDIGVQSIAKPMSGIGVNLAPVPAFRDDFSRKKLTSFDKLIEQTCSSIKNVRLCSETDQRPGGNTGSTGVAPDAAEIQLKSPNWLFGSRKPEESSSATKSGADDSEKGVTSTERVNDFCNLDWLSKSDRHQGDIFQRYLSITSTNEANGWYGGTLLGDQDENSEIYRHYAQFCQCPAMEPFENDHEFEQNFAEVLRMNTIDVMDIEEEETEMESDFNEYTQIGSDLGIIPMQCKHFASDPCWLARWLVGDDKVPKVI
The following text describes a protein:
Function:
Essential component of a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited by Ttk88 and probably acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. May serve as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval.
Subcellular Localization:
Nucleus.
Sequence:
MVLAERNTTDVVRNGRRSRGPSPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTKRNGKSKAKQSEYEEKIRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDNDDKIQKNRQVMEQLDKECETINVDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESGAEEQTEPAVDAAAAGAATASAPSAADSTSAASATADRKQSTENSNNGVETMQESLPKKEDPKKPELAAAVLKIGVAEAADAVATVASSTASGVIGAATSASKPSTSATITIIDESDTATNSSSDVVTTGLATSTGSSALSSTTSAPASKTQTSSEELSAQKSNPASGIAAIGAATGGGQTANSSGSKRDSSVLPVAEQPPAKKIALSTGGGSSVAEFLAN
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MERTHDDHLPPYLMVENHSDFSSYNHSPETLNLSLNLNQLIPSPSHETHFLWQNQLPQNRIPSSQSRATTVYQTLNPQNPLLQTHLFQNPSSQNHLLVQESHHQHQLPNYHQMNDFGSGLDSGLPINPSFAEPVRMQNHHHHHQLSLEDAFSRVNISAATSNHQFHQLLDENYLTNRGILSAYSQQQHSLNRMRSISAGLGLLRANSNSAIDRYYQNGSNNLAALGQSFSNYSNNNRQNFQRRTPSYDGLNYGHIVRPNPNRLDSSSSQFISRARSINGLDSENSRQLLSPLCYGRQIVQAGKHGNYSSLEQVRGRMAMVARDQDGCRFLQKKVEELIPEQTEMIFLEVKDHLYDLIVDQFANYLVQKLFLACNGVQINQLLLSLVQNGERLKNICIHMHGTRAMQKIIEIINNYPEQKASLVSALGNITVYLAKNHNGHHVIQQCLKCFEVEYTQYLLAEIAQSCIEIARDKSGCCVLQKALDSSYGELKECFITTITANASVLSVDPYGNYVVQYVLQMHIPHAEATILEQLRGQFVNLSMDKFGSNVVEKCLKECNEINAAGIVQELADSPSILRVLQHPFGNYVAQSALEVAPEDLYQYLERVIIFFERELHSHLHGKKVLARTRSGKRNNRVRAINVDY
The following text describes a protein:
Function:
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=Vacuolar and perivacuolar punctate structures.
Domain:
Contains a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2); The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway and for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium and in both its recruitment to and dissociation from the PAS under starvation conditions.
Sequence:
MKVLRFNQDASCFSAVSRPHSMTIYNCDPFGKCFELENSVVTSESCDTECLTKAQGDQCSNFVTEMLFATSLIAVVNRDQGLQKARKLRIVNTKRKTTICELTFPHEVVDIVMNRKRMCVLLSSDQIFIYDISCMKLLQTISVLEDKLKMAVSDQGHVSTSVVGRQLQGETSMVRIALCSDDKSILCYTAYCRTNKNSYILNDLVVYDALNMTPLNYLNTVHKGNVACLCISNDGKMVATASDKGTIVRIFSTGDENTLQSGNTLLHEFRRGTRPCSIYEMKIDPTRRYLACVGHTDTIHIFDLERQGQQNKSLSDSQSTALLREGKLSKESTLQFASFLSKKVISKIPNQNMERHFAHIKVDDSVRHCLGFPDEFSDRVYVASNNGEFQVWNIPQSGGECILVKKSKF
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MSKKITLKSSDGVSFQVDEAVALMSPRIKRMIEDDRTGNGITIPNVNSAALAKVIEYCKKHVEANADDTELKAWDLDFARALEGLDKDAFFAVASAAHSLNIGGLFDLTCKSVAEMVSGKTVDQIRDIFHIKNDYTDAEEAKMRKENAWAFE
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
EKRKNGDACSLCGCEKLLFEPPVFYCNGLTCRSKRIRRNSYFFVGGNNQYHWCQPCFDDMKDNQKLELADMTLTKNQLDKKKNNEVPEESWVQCDRCERWIHQICALFNTRQNKDQRSEFVCPSCTIEDREKKNKLEPSSTTPMAEDLPRTKLSEHLEKHVREKFHEEMARMAKERSEKEDITYDGGGEIYIRQVSSMTRTLDVRERMRKRYSFKNYPSEFKYRCKCIIVFQNLDGVDVILFGLYVYEHDETNPMPDQRAVYVSYLDSVHYMRPRRMRTFVYHELLISYLDYVRNKGYSTAHIWACPPLKGDDYILFAKPEDQKIPKDDRLRQWYLDMLKDCQKRGIVGKLTNAYDLYFANPKNDATVLPYMEGDYFPAELENIIKDLEEGKNLSKKPDGSGKKKGKKEKKTKKAASGILAEGVDVKSLQAGGRDAVMKKLGETIHPMKESFLVAFLDWEGAKEEDRVVPKDVMEYREKHGINIRKSVVPPSGMDIEELEDSPKEKPDDEMDCEFLNNRQLFLNLCQGNHYQFDQLRRAKHTSMMVLWHLHNRDAPKFVQQCAVCSREILQGNRYHCPTCADYDMCQECMTNPGVPRHQHPLKAIPVGNQQNNLTAEQRKERQRSIQLHMTLLLHAATCKSQKCASANCAKMKGLLKHGSSCKVKANGGCHVCKRIWALLQIHARQCKEDNCPVPNCMAIRERFRQLTLQQQAMDDRRRQMMNQTYHQQAR
The following text describes a protein:
Function:
Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.
Sequence:
MQASQSIYKSPNDHRQYRYLQLDNALRVLLVEDLDASQAAASMAVAVGHFDDPADRPGMAHFLEHMLFLGTEKFPDSGEYHAFINQHGGSNNAWTGTEHTNFFFTINADVFADSLDRFSQFFIAPKFDLELVDRERQAIESEFSLKLKDDIRRTYQVLKETVNQQHPFSKFSVGNLVTLGGEQAQVRSELLTFYQTHYSANLMTLCLVAPMSLDALQALAMQYFSEIRNLNIVKQYPQVPLFSENELLKQINIVPLKEQKRLSISFNFPGIDHYYKRKPLTYISHILGNESKGSLLSYLKEQGLVNNLSAGGGVNGYNFKDYSIGLQLTDKGMSNIDDIVCSCFEYIELIKTQGLEDWRYLERANLLKMAFRYQEQVKSLDLASHLSINMHHYEVEDLLFGDYRMDGLDVAETLELLALMTPQNMRLQLIAQSVATERKASWYHTPYQVLPIKPESLARWQVTDIRPELQLPAANPFIVADSIARPDKSEVAVPVIVAESAGYRIWHKKDDEFNVPKGHMYLSLDSEQASKTPKHAALTRLYVEMLLDYLTEPTYQAEVAGLSYNIYPHQGGITLHLSGFTGNQETLLALLIHKARERNFTEERFALIKSQLLRSWQNLAQAKPISQLFTSLTATLQKRSYEPARMAQVLEDITLNDLHNHVRAFYEKIYLEGLIYGDWLVSEAQALGKRLEHILSLVSSPSAESTRELINLTGQGTLLRELAIDHQDSAIIVYYQSATATPEKMALFSLLNHTMSSTFFHELRTEKQLGYMVGTGYLPLNRHPGLIFYIQSPTTGPLSLLEAIDEFIADFNYAVMQITNEEWESTKQGLINQVMEHDANLKTRGQRYWVSVGNRDYQFNQRELVVAEISKLTRPDLLKFMMQKMRTKHSDRLVLFSTGSAHTAQSALTSDNMITDLKVFKQNTEKFNF
The following text describes a protein:
Function:
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Sequence:
MSLETALQSLKRGEFVLLFDSAGRENEIDMMVAAEFVTPEHVARMRQHAGGLLCIAIDNQFANSLELKYMHDILADSSISNKEMIMGLAPYGDHPTFSLSVNHYQTYTGITDNDRSLTIREMANIYNVENKQKKFASSFKTPGHVPLLIASKGLLAARQGHTEMSVYLTQIAGLTPVSAICEMMDAETYTALSVDKAEKFAKQNGIPLIDGKELLEYAKVH
The following text describes a protein:
Function:
Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cell cortex. Apical cell membrane. Cell junction, tight junction. Note=Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells. In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis.
Sequence:
MAGAAMAERGRVPPPAPAPSTEGLPRAFLQSLRTLFDILDDRRRGCVHLREIESRWQGTDARELPRGVLEGLRQVAPASGYLTFERFVAGLRTSLLSADGGPRDPTRAPARPGDQPPPPPQRLVFAPADEPRTVLERKPLPLGVRAPLAGPSAAARSPEQLCAPAEAAPCPAEPERSQSAALEPSSSADAGAVACRALEADSGDARRAPRARGERRRHTIASGVDCGLLKQMKELEQEKEVLLQGLEMMARGRDWYQQQLQRVQERQRRLGQSRASADFGAAGSPRPLGRLLPKVQEVARCLGELLAAACASRALPPSSSGPPCPALTSTSPPVWQQQTILMLKEQNRLLTQEVTEKSERITQLEQEKSALIKQLFEARALSQQDGGPLDSTFI
The following text describes a protein:
Function:
Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates 'Ser-2' in the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation. Required for normal reproduction.
Subcellular Localization:
Nucleus.
Sequence:
MEISPGSSTHERDRKGSYGHRERTRSHSGSPSRFYSKDKRGSSRQGVRPRDRDSKDSISPQYKQRNWSRGGGGGGRDRGRNDFSYRKKGKDYNKRRDKRSRSRSRHRSPKRSGSSKKSKRRNSSGSSSSDLMDTSLMSELKKHGDYGSSSKSKKKSRKRRKHSSSSSSSSGEAMDLPVSSNGMNVTAIPPPPSFNINPFQPMFSQPPPPPLPPNSQFMTPPPRPPPAPFSIPPPSVDIHFAATASFSLSSIPPPPPQTDGGASSSKRQDPLPMPPDSKRIATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFRMKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEMWSKKQKKSARLGRQAEGSSGSGHSIRATSHPRAPTQPSTTTTKSNGSSNHHHHHHHSHHHASSLPPSGGHAPPPPPPPTQASSTSHNNHQPVPQSQYQSVFFK
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDVWEIPRDCVTLGDRIGEGQFGIVFAGTVKIGEDTIKAAIKCIKDVDDRYDMKDLKLEMEMMKEIGYHPNVVSLIGTCTIETPLYIITEYVSGGNLLDQLRQSRRTDSKYVNVNSTLTSRDLLRIALDVSRGMRHIAMKKFVHRDLAARNVLMTDTLTAKVADFGLARDIYCEGKYVKTGGGRLPIKWMAPEAIRDQVYTTQTDVWSFGVLLWEIVTLGRSPYPGVPIAMLLEKLLYGYKMPCPSHCSEEVYSVMESCWQLEPSARPGFGELSKILTEMLS
The following text describes a protein:
Function:
Required for YwqD kinase activity. May bring YwqD and its substrates into contact. Probably involved in the regulation of capsular polysaccharide biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIYENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQELNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKAEVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLGTVSTIANEQKTAKTLQGFQSEKTGSGHFGA
The following text describes a protein:
Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Subcellular Localization:
Cytoplasm. Mitochondrion intermembrane space.
Domain:
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation; The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters; The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Sequence:
MSNLLVFDNSVVTDEALVANIMAQNQGASHQLLERIGTQVQLPANTYASIQVFTKSPQPVTLPASLLETLSGALAPGGALFGAVDGSQVMDFIMAGLAQDGDKWVKPAATGTTLLKKSGGGPKKFAFKRASPATAAPSTNGTNPAATVNLNSVVTLSMDDDDLMDEDDLMEDDTNLSMPIKIPAKCDPGPGKKRRKACKDCTCGLKEMEEQAKDAQLAAQNTVTLSAEDTAEIDFTVQGKTGGCGSCALGDAFRCDGCPYLGLPPFKPGEAVSIGGASDL
The following text describes a protein:
Function:
Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MVLSYSAIAKPTADTPKVISMTASKQVFPEAFEALPAPAAEESQELESQPEALAQASSSTIEAPISSEDRKVIQHLILDAGPLLSLTPLRHLATSFHTTPMVLAELRDPKAREHWERLALTGVNVKVESPTAEAMAQVTAFAKKTGDFAVLSQTDLSVAALTYQYEVMVNGVKRIRTEPPQAKKPSAKGKEKEKDTKQAEKKDEEVQENKNEKEGKPEEEDVEVEEAIQSLSQIIIEPSTKSELSVNDVSTTNRSHTQTSVPASAHAEDPESEGEWINPTNLSTHRSRDLGLITPSGSTAKPPAVACMTGDYAVQNILLGMRLGLVGEGGKKIGKVKSWVLRCHACFKVCKDPSKRFCPSCGNATLLRTSVSTSAKTGEQRVHLKQNFQYRTRGTIYSIPDPKMGRAKGQQKGGSGLILREDQREWQDAMRGDRIKKEKEERKAAKGALEGWNDPDWLPEMITVGMSGKGRSGGHNMPSIGHGRKNPNQAKRRR
The following text describes a protein:
Function:
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Subcellular Localization:
Secreted.
Sequence:
MYRMQLLFCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
The following text describes a protein:
Function:
Functions as an activator subunit for the DBF2 protein kinase. Binds to DBF2, which is required for the phosphorylation and activation of DBF2 by the upstream kinase CDC15 in late anaphase. DBF2-MOB1 is part of the mitotic exit network (MEN) signaling cascade, which regulates release from the nucleus and activity of phosphatase CDC14. Required for inactivation of mitotic cyclin-dependent kinase for exit from mitosis, cytokinesis and G1 gene transcription.
Miscellaneous:
MISCELLANEOUS: Present with 5020 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Bud neck. Chromosome, centromere. Note=Localizes predominantly to the cytoplasmic surface of the spindle pole body during anaphase and to a ring at the bud neck during cytokinesis. Translocates to the nucleus during mitosis and associates with centromere DNA.
Sequence:
MSFLQNFHISPGQTIRSTRGFKWNTANAANNAGSVSPTKATPHNNTINGNNNNANTINNRADFTNNPVNGYNESDHGRMSPVLTTPKRHAPPPEQLQNVTDFNYTPSHQKPFLQPQAGTTVTTHQDIKQIVEMTLGSEGVLNQAVKLPRGEDENEWLAVHCVDFYNQINMLYGSITEFCSPQTCPRMIATNEYEYLWAFQKGQPPVSVSAPKYVECLMRWCQDQFDDESLFPSKVTGTFPEGFIQRVIQPILRRLFRVYAHIYCHHFNEILELNLQTVLNTSFRHFCLFAQEFELLRPADFGPLLELVMELRDR
The following text describes a protein:
Function:
Histone methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MLASRIPPKRCTAAVPYELEPPAAAAEGMPPAKRRRERVLPSRFRDSAVLLPPPAKKACKAPAPPKVEDRDGQVYEVEVRAVGPKGSAFGAVQTEVWTGEPAQTEEELYRACRNISRSGSSGCFSGSVVTSVSNAGEKCAPEKTPVVGAVVPSTSNAGTGNVGLEGRSPVVECKPKQEAEVRREDFYWPEDFVLGDVVWARSGKKSPAWPALVINPLQHAPEVVLNSCVPGALCVMFFGYSAGGQNRDYGWVKQGMIFPFVEYLDRFQGQSLHKLKLKPSKFRAAIEEAFLAERGFFELQMDGVCSLDKSVNEQSVTDGAREVTGSNNEQECQSHSQVVVKLAACCDSCGNRLPSKISKKKKQETEQLLCRHCEKLLQSKQYCGICKKIWHHTDGGNWVCCDECQIWVHVECDRTCSDLEDLENTEYFCPDCKSKRKRVMKVEQTSTSNSSEFASTSKEKLPESIPVCCSGMEALYLPEKHMILCECRSCKKKMMTLNEWERHTGSRKKNWKMSIKLKGTGEPLIDLLHDIPGGNFKSSTPGIKKEELLSLQANSYSPVYAKWTTERCAVCRWVEDWDYNKIIICNRCQIAVHQECYGARVVQDLTNWVCRACELPQQKKECCLCPVKGGALKPTDIDQLWVHVMCAWYQPKVSFPVDETMEPAVGILSIPSEYFKKTCIICKQMHGACTQCYKCSTYYHATCASRAGYRMELQYSERNGRKVTKMVSYCAFHSTPDPDNVLIVKTPDGVFSTKFLLQNNEKQSPARLAKSENHQEVFPAEVSDCPAARCLPYEILKNKKQQGEAVAHRIMGPRHHSQDLIEALNTYMQDQKGDRPFATFKERLQYLQRTENKRVSCGRSGVHGWGLFAVRKIQEGQMVIEYRGDQVRRSVADLREARYHKENKDCYLFKISEDVVIDATERGNIARIINHSCMPNCYARIVSVGDNKSQIILIARRDVSAGEELTYDYKFDPDESEDRKVPCLCKAPNCRGYMN
The following text describes a protein:
Function:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEATRSDDPSLNPIRNRNPNPNPNPNPLSTIISSAQVWPTIDGPLGLTEEASVDYARRFYKFGFALLPWLWFVNCFYFWPVLRHSRAFPQIRNYVVRSAIGFSVFTALLSAWALTFSIGGEQLFGPLYDKLVMYNVADRLGLSGLA
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MIHSELEAMSRYASLMTPAVCPHLTVLLSAIGIFTAWSSAYDVTSTKDTWDICVELLTSLVVSLLPGSETTCCSAVLGWPLHISSQGFQPGSFTESHLWQINFFFFYYCQKRPTYCSQ
The following text describes a protein:
Function:
Binds to histones H3K4me1, H3K4me2 and H3K4me3 in GST pull-down assay. May facilitate the recruitment of effectors to mediate gene expression (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The CW-type zinc finger domain is not required for nuclear localization.
Sequence:
MPSNGGIIPGPANAASLPAPVLIEDNWVCCDMCHKWRLLPYGTNTSMLPKKWICSMLDWLPGMNKCDISEDETTNALNALYVTQIPAAGVSSGGPHTAHASVAASSTYNISGQLGQSRKRKNALKDENCYEHDQQAPAKMTLTSNQQAPAKNREVVDSEHYTNDRDPVSTHDLVPQSKSASERHKSKHKSRSSHSDGGDLTEKSKKHSKSKNRRGIDRDEHKTSKKTKKEDRHYFNKDWKNEYDLAGNKVRDETKALSAKAKMSKDSCEQDEFSLRKEKASRFDILEKTKRINDDDVAFHEKMKEHRAGIETLDLSGKKKTVKEWEDNRLSSMDHTSKGGDNENLNERLSKIKKSEARPEEVQDANALFSSAGRRQDNELVADNKFVTCKEGPSELWDNQPPRQVLNLAEPTRRDVACLQSSTVATSSSSKVSSSRRNKNSREAKGSPVESVSSSPLKNSNTDKISKARKTGKDGELNADSSILHTPMKYPTHEVGLLHTGQQAVGEAILRGSTNNSGMGRVDNQLYPGDKKILDMHGPTLQPDQQDCFNPRATADSTGHKSKNSAPSRQGRNGSSNLISEGNKQIEMSSRKEKLRPSIDNQDMQKSIGQDNHSHMKEGKSEVHTTRVKPGASKNHTQLRSNVENGDSASPIRRDGNMIAFALKEARDLKHKANHLKEKGLELESMGLYFEAALKFLHVASLWETPNLDNSRSGDVAQSMKMYSETAKLCSFCAHAYERCNKMASAALAYKCVEVAYLKAAYYKHPSASKDRQELQSVVQIAPGESPSSSASDIDNLNSHGLSKALSTKGGNSPQVAGNHLPLAVRNQAHLLRLLAYTNDVNCAFDATRKSQVAIASAASSQERGKTVDDGLASVRTVLDFNFNNVNELLRLVRLSMELINT
The following text describes a protein:
Function:
Probably functions as a manganese efflux pump.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEVQELFLLALAISLDAFGVILCIGINKGITLKSSMIFVFSFGFFQFFLSFLGGYIGTIFNKYIVPIPTIVGGLIIIIVGILMITEGFKEKEESIFLNKIMYLILGVSVSIDALVIGFTTLSYINNLFYLFMSSLFMGLIATIICSLGIILSKYIKKISIISSYADYIGGIILILFGLKMLFF
The following text describes a protein:
Function:
Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation.
Miscellaneous:
MISCELLANEOUS: The DNA sequences encoding comQ, comX and the N-terminal two-thirds of comP show a striking polymorphism, which determines the specificity of the quorum-sensing system in the different pherotypes of Bacillus.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQFMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHLKDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISIAYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIFNLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLILTNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILGRMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFRLKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKVIFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINTPRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEKQRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVISMTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLYRIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGIKERVRALDGRLRIETSEGKGFKADIEIEL
The following text describes a protein:
Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAVAPAAGQGSHNQQKKTFFLGDGQKLKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELIAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASAATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEHIYQRRPEYRHLSAGDVAAQKQLRSSLNCKTFRWFMTQIAWDLPKFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLESCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAVSHTSPVTLYDCHSMKGNQLWKYRKDKTLYHPVSGSCVDCSESDHRIFMNTCNPSSRTQQWLFEHTNSTVLEKFNRN
The following text describes a protein:
Function:
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Subcellular Localization:
Cytoplasm.
Sequence:
MPIIIDKDLPARKVLQKENIFVMTKERAETQDIRALKIAILNLMPTKQDTEAQLLRLIGNTPLQLDVHLLHMESHLSRNVTQEHLTSFYKTFRDIENEKFDGLIITGAPVETLAFEEVDYWEELKHIMEYSKTNVTSTLHICWGAQAGLYYHYGVPKYPLKEKMFGVFEHEVCEQHVKLLQGFDELFFAPHSRHTEVRENDIREVKELTLLANSEEAGVHLVIGPEGRQVFALGHSEYSCETLKQEYERDRDKGLNIDVPKNYFKHNNPDEKPLVRWRSHGNLLFSNWLNYYVYQETPYIL