lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MALITLRRMLQGISSDVIAIEARITQSIGRILFTRHELAPVGCSIDDEKDISQREGFLLMAVPKRKTTPSKKKLRHQHKWLKNRTDIEVCAVCGNHKLLGHLCGQCLEKVNVDTREYRKNKNPDDSHWPIPEVLKKFRLY
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MNIMRLLPRSKALSSPTAVAPAFRGRGAGVYSPSSQTVYMCPTSAVSLMHCSPCSTSAPLRSSQKSVAQTSANNDSLSDKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTDA
The following text describes a protein:
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MPLIKREVEPVLVSQVDIGKDVKNELECVTNYTLASIIRQLGNLGKHAEDIFGDLLHEATSLARRAGSVQDRLDKLNKTFDKLDPQTDSVSLRDINTRLAFQSSLILDAEVVSSPTMPSAMKATYTRCEQTPPLSKLNQFRQDGKDGLKMYTDPKFFFERWKNEQHKDIDKKKKKKKKRPHSSNMSKPKKVLTTKEKYKDRALGEEFAAMEREKRAQEKASSGTTSIAKDDNSGEEEKSSKGNSHLAGPTKTRKKETPESIRKPGMAPPPAPGPPPAPISKGGVQNSSEMSLPPPPPPLDYDNPYSEVGDMPPPPPVSGYVAPPSSGIPGAPPVPAPPPPLPSSAGPTPPPPPPLPAAGAPPLPPPIQRQTSVTTNPRPTTAVSQVTGARDDLLSAIKSGMKLRRVEIKVRDRPNEPENNSVEAILRRRIAVELSSDEETGSDVSDDSDWDDEEDD
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MATTKDSINAAQLKKNILKLCLCHLSFQEPNQRALIIESQHILDAGGLKMEEDAILQKSLKWLRDLSKGNISHELEALTLEGLQIVHAQKGSIRCNFVVPTRASDPDGNWHVGAMATLIDDVAATAIYSVVDHVKLSLDFSISFYSTAKIQEEVEIEAKVIGEKGSLTQVVVEVTRKGNRELIALGKQWMASDKKGMKPSQVSSKL
The following text describes a protein:
Function:
Essential sperm cell-surface protein required for sperm-egg fusion and fertilization.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Multi-pass membrane protein. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm.
Sequence:
MPKVMKDVVHPLGGEEPSMARAVVRSVGGFTLGLSLATAYGLLELLVEGHSPWGCLVGTLTLAAFLSLGMGFSRQVRATVLLLLPQAFSRQGRTLLLVAAFGLVLQGPCANTLRNFTRASEAVACGAELALNQTAEVLQRAKQPLVSALNKIKAIARKTKEVADRVRKFFRSIMDGVKHIARALRNVWQWLLHIGDVCNSELGNPYLKCARVFDDAKDSCMMVIPQAYHLCYVLMPFKLALCGLASLVQVFCVIPKYIQPFLRQTIGTPVIQLLNRVRQEFEFNMTATHHFSVDLNASRSLSQVAMDLHEAVSMKLHRVREALALMGFTTPLLLVLLYLQALFYRYCYLNWDHYDNIYITSRFLRMEAVRSTAGLPTVLPLSAHEARRYIPPGSIFLSQWEKFFYILETFNLIRHLLLVLFLVFLDYAVFWVLDLARHQLQGEIVARSPVLVSLTVEGTGYAGNIYRDLVSAFDVLQQGNISILSRRCLLRPSEPDSTGYIVIGVMYGLCFFITLFGSYVSRLRRVICASYYPSREQERISYLYNVLLSRRTNLLAALHRSVRRRAADQGHRSAFLVLASRCPCLGPFVSHFWLHQAYCLGCGQPQDEGDMENTVSCSTPGCQGLYCLTCFRLLDNTCSVCASPLSYQGDLDLELDSSDEEGPQLWLAAAQRKDPEQAWLLQQQLQEVLGRSLSMESTSESSDLDEEKGPQQRKHGQQPLPEAHQPVSILTSPEPHRPPETSSATKGAPTPASEPSVPLSPPSLPDPSHPPPK
The following text describes a protein:
Function:
May be a component of the oxygen-evolving complex.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Sequence:
MASMTMTATFFPAVAKVPSATGGRRLSVVRASTSDNTPSLEVKEQSSTTMRRDLMFTAAAAAVCSLAKVAMAEEEEPKRGTEAAKKKYAQVCVTMPTAKICRY
The following text describes a protein:
Function:
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MNEYHPDSHGRPRRSKWDTPLSMGMAPAPGPAPPAPSPYPTAAAAAAAAQMLDGQVSSLEAASAAAARINAMLISKGKLKLPPGIVPLEPDTKQQKQVKLPVKEEKGKNETLVAEVEINEVPIQCRNMLTKGSTQEEISRLTGAAVSTRGRYMSYADRATNNMGERPLYLCVQGPTRESVDRAVEHIKALIEGGMQGKQGGAPTVNRTRSRFSAATTGPAGAVNTRPQGVPIFSHPPAPGLGAQMRGPALGGGDVRGPGVAGGAGGLRGPVPHPMVPPPAIQLAIQTAQSSGHYLQDKVFVGMEHADPSFSIKDKILGPAGSFLHHIRAETGANIYLRGRGSGFMEPTSGREAFENLYIYVTHPKVDGLQAAKKLCENLVVTIQAEYMTHQSQIFQRSAPAMAAAHMIAAPPRPPQQPLAQQAIPQQQQPPPQHQQQQMHHPAALGLYSQAQPTVPAAASTVMSQTLAAQQQAQAILGAAQRPVVSAAVSIQQGIVYPHLSAQPQLGLPGQPGLALQVRAPQPVPAPAPVPPPQRLPPPLPPVGVPAASQAQLYVTHVAVSQGQQNLVQAHAQGQQSLAQAHAQAAVQAAHAQVQAHAQAQLAQAQAQIQLPVQQQPAGGGLAMGQPQQVLQQPLGPPPQQQQQQLQQQQPQPPQPQQPVKRRFREDLPAERPEHHPPPMTNLGVSPPGHSPLGIAGAMAAGHGSLLRMPGRPPEDRRLMPPPPNPQAMQEAARKRLMLPPGLDIHGGRIPLPDEPRLKRGRGLVSYDTSGDSDEDEEAAGRARTRFDAGPHFQVPSAGGYMAAPPPPRGLLPPSSLSTSTATSSAAYYNVERREPGPGGSPFWMARN
The following text describes a protein:
Function:
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Subcellular Localization:
Cell projection, ruffle membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Early endosome. Nucleus.
Sequence:
MELAAWCRWGLLLALLPPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPADASLSFLQEIQEVQGYVLIAHNRVSQVPLQRLRIVRGTQLFEEHYALAVLDNGDFLESAAPAAGTAPGGLQELQLRSLTEILKGGVLIQRNPQLCHQDTILWEDIFHKNNQLPLKQIDTNRSRACAPCSPACKAPNCWGESSQDCQSLTRTVCASGCARCKGPQPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSKPCAPVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFAGDPDSNIAPLQAEQLKVFESLEEITGYLYISAWPDSLPDLSVFQNLRVIRGRVLHDGAYSLTLQGLGISWLGLRSLRELGSGLALIHRNARLCFVHTVPWDQLFQNPHQALLHSANRPEDECVGEGLACYPLCAQGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVKDRYCLPCHPECHPQNGSVTCFGSEADQCVACAHYKDPPFCVARCPSGVKPDLSFMPIWKFPDEEGICQPCPINCTHSCVDLDDKGCPAEQRASPVTSIIAAVVGVLLVVLVGLVFGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVAEFSRMARDPQRFVVIQNEDMGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAAGTAHRRHRSTSTRSGGGELTLGLEPSEEEPPRSPLAPSEGAGSDVFDGDLGMGAAKGLQPLPQHDSSPLQRYSEDPTVPLSPEADGYVAPLTCSPQPGMKSGSS
The following text describes a protein:
Function:
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit sdh2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MALSGLQRQVIHFYRRCLHAAKAKEQPYNERWMAFVHQEFRKNQTISKRDFFYIEHLLRVGQRQYEAYSRPEVKDIHFS
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MANVQQRYGITEPISLGGPTELDVVKTRELEKYLQDVGLYEGKEEAVRREEVLGRLDQIVKTWIKTISRAKGLNDQLLHEANAEIFTFGSYRLGVHGPGADIDTLCVGPRHATREGDFFGELQRMLSEMPEVTELHPVPDAHVPLMGFKLNGISIDLLYAQLPLWVIPKDLDISQDSILQNADEQTVRSLNGCRVTDQILRLVPNIEVSGFLGGINWALLVARICQLYPNALPNMLASRFFRVYTQWRWPNPVLLCSIDGGSFGLQVWDPRRNPKDRLHMMPIITPAYPCMNSSYNVSASTLRIMTGEFQRGKDICEAMEANKADWDTLFEPFAFFEAYKNYLQIDISAANVDDLRKWKGWVESRLRQLTLKIERYTYDMLQCHPHTHDYQDASRPLHCSYFMGLQRKQGVPAAEGEQFDIRRTVEEFKHTVNGYMLWIPGMEIGVSHIKRRSIPSFVFPGGVRPSHASKGTWDSKRRSENRITSTASAATATTTNEASSESKGGSNSSGDGKKRKRGDDETLTDQLKNSKRLSVSVPVENGEGGSPDPSGGSVCSSPPKDCCTNGKSDPVIKDPPESVVVFSKDATESHPIEKIATPQARSQETEELEDGFDFGNQVIEQISNKDTFLAASATILPSETNTSNGSPFSNEAVEELEVLPMPQPEVMHRASVQQRKPIIKLNFTSLGKTNGK
The following text describes a protein:
Function:
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular Localization:
Secreted.
Sequence:
MARLGSFVAVLVLVCAASFVNVADSAGLVNNFYRKSCPNAEKIIRDSIYRMYEKKGNIATSFIRFGFHDFFNGADASFFLLSAPGKTSEKDSHSMVGMRNEKYVNNIKAEVEKVCPGVVSCADILAVGSAAAVQVLGGPYIHVKTGRKDTRNSMKSSADTIPRPQDGVTKVLTFYKNIGINPREAVALMGAHTIGRAHCTSFIERIFPKVDPKMDPVFAEKLKRRCPAKPTSVHFTYFRNDEPSPMAFDNNYFKNLVTKQGLMGIDSALYWDGRTQKYVIEFSQNEAAWREVFTVAFKKLSEYKVLTGRQGEIRKRCMYVN
The following text describes a protein:
Function:
Involved in protein precursor import into chloroplasts.
Subcellular Localization:
Plastid, chloroplast inner membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Sequence:
MSALLSQASGFSGLALGSSASSKRLCKPLCRRPAVCVQAAHRPASAVSSGVPSTGFGPVSPLQRRPTLPTRKLVVASSQSGGRAEDAEKQDWKFGRNEGPMTWPWKLMCAILYMLPWVDVTEKTVYFVERFPAFVWTEYFSEPFEHWYNIHEYAPLFIFFATYLGIVRNKKIPHVARYHVMMGVMLDIVAMILIVTEENLPTGVLWTPWSDLFYALMFWFIFLLVIYCLFFCFLGWYCEIPLISEGVYLQIEQAEQLGQ
The following text describes a protein:
Function:
GTPase required for the nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of Nmd3 from the 60S ribosomal subunit after export into the cytoplasm. Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exerts global growth control.
Subcellular Localization:
Cytoplasm. Note=Punctate distribution.
Domain:
In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Sequence:
MGKKNKGGAPNLGRQLIKDRFGHTQRRKVDNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAFLRTAELAGTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKIPRRPKWTKETSAEELVRAENEAFLDWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARNPLLFRSADLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKREAEECLDSFPEVQQLRRAVEEIKQSLDSVEDALNVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELIEFLRNIYTGPRHTEQHVTVGMVGYPNVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKADMLLNGILPIDQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSEELLLAYGYNRGFMTSNGQPDQARSARYVLKDYVNGRLLYAMSPPSVPQTEYHTFPERQRRVIEESQLPGQQQRAMRINKSTSKELDNQFFSDKPTHAHVKGRTNFPNVRLANDGSLVAGNDPAAKPWRHVKKERREKLRKKFSHLDEH
The following text describes a protein:
Function:
Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation. Inhibits root growth and regulates root meristems. Promotes ROS production and MAPK (e.g. MPK3, MPK4 and MPK6) activation in a MIK2-dependent manner, thus leading to the up-regulation of immune-related marker genes (e.g. WRKY30, WRKY33 and CYP81F2).
Subcellular Localization:
Cell membrane. Secreted, extracellular space, apoplast. Note=The precursor of SCOOP10, PROSCOOP10, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP10 in the apoplasm.
Sequence:
MERKKFSSKFIHLLIVFLLLCTFLSRTESALPYHHELFLGRKRMNYYKPNSAIGTPSSTSDHAPGSNGRKLMSIYRPNGDIFTGPSGSGHGGGRTPAP
The following text describes a protein:
Function:
May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.
Sequence:
MGTTQEAGEKTLDLGAMEDAEARKPAGSLRLGELELREEWQDEDFPRFLPEEADPSEDPDNPERDSQAAPGTPSTLALCGPRPMRKRLSAPELRLNLTKGTGGDGTCPTHSVPSSPDGSSDLEVDELETPSDSEQLDSGHEFEWEDDLPRAEGLGASEAVERLGRACMRDVAGEDGRHWRVFRTGQREQRVDMTVIEHYKKVLSHGGYHGEGLNAVIVFASCYLPSSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLGWMRQCYHTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLNSLGELAQLISLDQVHIPEAVRQLDRFHGSGGT
The following text describes a protein:
Function:
Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.
Sequence:
MTSLAGNLLPDGDQTQGGSWLDDLGTQSSATKEADNIAPQSPLPGSQGRRRAQGALDQQSLHHHFFHINPSPPNSRTKRSSCQRRGKPSWTGGAGYIGSHVLLCCLLTRKYKVITIDNFHNSFPPAIERVSRIALSELPNDASEEDKLFTNVTLYKGDITCKADIEKVFETEKVWGVIHIAAHKAVGESGEKPIQYYENNISATINLLDVMNRHDCHHLVYSSSATVYGAPTTIPIPETTPLAPESVYGRTKMMSELIIKDLCDSQPTKWKAISLRYFNPAGAHPSGLIGEDPVGRPGNLLPLLAQMAVGKIPHDLKVNGNDYPTRDGCCIRDYIHVMDLAAGHINALDGLTKESTWSTPCAGFKSAFGTSGGKYKAYNLGKGRGQTVFEMIEAMRKATGFDFKYEIISRRAGDVPDLTADPTLAMKELGFSAPRELDEMCRDLWNWQSKNPKGYA
The following text describes a protein:
Function:
Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Transcriptional regulator of circadian rhythms with poly(A)-degrading activity that affects the expression and rhythmicity of the clock core oscillator genes TOC1 and CCA1. Deadenylation may be a mechanism involved in the regulation of the circadian clock. May play a negative role in response against oxidative stress. Possesses magnesium-dependent poly(A)-specific exoribonuclease activity in vitro and is almost inactive with poly(U), poly(C) and poly(G) as substrates.
Miscellaneous:
MISCELLANEOUS: Plants overexpressing CCR4-4 exhibit retarded growth phenotype and severe reduction in root length that is attenuated over time; MISCELLANEOUS: [Isoform 4]: May be due to intron retention; MISCELLANEOUS: [Isoform 5]: May be due to intron retention.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MFSSTTLHHLPRPNLLLPRKVISRRMSTNPAIEPKVRKFESVEGVDIGSRNKSDGFFAIPLYLSKLVALYNCISLSRIGTSNENFVFSGIRFRLVSYNILAQVYVKSALLPHSPPACLKWKARSHAILSVLKNLQADFFCLQEVDEYDSFYRNNMDSLGYSGIYIQRTGQRKRDGCAIFYKPSCAELVTKERIEYNDLVDSIKADSVSCSEQKIETSNEGKDSRKDSRDLNDPLVRLKRDCVGIMAAFRINKPFQHIVIVANTHLYWDPELADVKLAQAKYLLSRLAQFKTLISDEFECTPSLLLAGDFNSIPGDMVYSYLVSGNAKPTETIEEEEAPVPLSSVYEVTRGEPKFTNCTPGFTNTLDYIFISPSDFIKPVSILQLPEPDSPDVVGFLPNHHHPSDHLPIGAEFEIRRE
The following text describes a protein:
Function:
Required for tolerance to alcohol.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Accumulates in the nucleus specifically upon alcohol stress.
Sequence:
MLKHISSHIAMGCPQDECSICWESMPSGVGRLMPCGHEYHLACIRKWFHLHSGNRSCPVCRTEASVLVDTDHEVKIDLSVGQLLDFYGLLDEIGSQLLAITLQDHSTQDDEVNEEGLAEQRAQLTLVQCGICGEMNGDIDTCCNRCHHMYHHSCLGQLLVEVNAEREQGWSHCIFCYEQLVPLYISGARRVLSLQDRGVHRGRVRNNRSILTELIYERSGVLVHGIEDQHASQHDINDIEHSWHLLEQNRQRKQLEYQDKCKIQAHVRRILDHYYHCAKVTKAQYTFINKKVSQTLYALSRGVYPAVDLDYDGIAKTLILDEMEKLSS
The following text describes a protein:
Function:
Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity.
Subcellular Localization:
Secreted.
Sequence:
MATMIVLLMVSMLTIPCVGGHALDTPNPQELPPGLSKNINITFFNGVFKNVESVTEIFDCLGSHFTWLQAVFTNFPLLLQFVNSMRCVAGLCPRDFEDYGCACRFEMEGLPLDESDSCCFQHRRCYEEAVEMDCLQDPAKLSADVDCISKQITCESEDPCERLLCTCDKAAVECLAQSGINSSLNFLDASFCLVQTPETTSGKAVTPPPRGVPEKPTDTSQIAQSGEVAGERRADTLTTLSRTKSVQDLQDIQASRTTSSPGSAEIIAIAKGTTHGSAGIKSVRLEVSSVDNSSRETTGKACGRLAFLHLGDGGSMKAMLHLGEMLFCLTSHCPEEFESYGCYCGREGRGVPRDTLDRCCLSHHCCLEQMRQLGCLHGRHSRSSVVCEHHTPKCVGQSLCEKLLCACDQMAAECMASAFFNQSLKSPDQPECQGEPVSCEDGMLGGTLASSVDSSSEENSEEAAPQMEPLRSRLQEKPSGPLGIRTLGGR
The following text describes a protein:
Function:
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain.
Subcellular Localization:
Nucleus.
Domain:
The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.
Sequence:
MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASSASSSAAATVTSPGGGGGGSGGGGGSGGNGGGGGSNCNPSLAAGSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGSSGGSWDKETLHSPPSQGSQAPVAHARMPAAFSLPVSHPLNHLQHSHLPPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRIHIEKDETPLSTPTARDSIDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASADSLRVLNDSLTPEIEADRSGGRADAERTIQDGRLYLKTTVMY
The following text describes a protein:
Function:
Structural component of gap junctions. Plays a role in maintaining gap junction activity to promote phayngeal muscle contraction.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Note=Partially co-localizes with F-actin at gap junctions between EA and EP endodermal precursor cells in embryos.
Sequence:
MLGVPFIDRWLSETFKPKTFDDAVDRLSYVTTATLLAFFSIMVSCKQYVGSAIQCWMPMEFKGGWEQYAEDYCFIQNTFFIPERSEIPGDVEDRQKAEIGYYQWVPIVLAIQAFMFYLPSWIWSSLYKQCGLDFPSVISEAEALRSQDSETRTKGVNKLVDFIGDILDTRSKNEYGRFYCYRFGKGLGSMTSMLYICIKLMYLANVFVQFIILNKFLGNETFLWGFHTFADLYAGREWQDSGVFPRVTLCDFSVRKLANVHRYTVQCVLMINMFNEKIYLFIWFWFVFVLITTFINTLCTIYRLSFDSSRHNYIRSLLSGPVNNFKDEKAMIASFANNGLKQDGVLLMRFIDDHAGAMVTKEICEELFKKHGENLQHNRDFHHGHSTKSTSPGLEEGHHEHLYTPEKMKLMAPDYPIKHA
The following text describes a protein:
Function:
tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the two cytidine residues to tRNA.
Domain:
Adopts a seahorse-like shape and consists of four domains: head, neck, body, and tail.
Sequence:
MENIEIVSSGKHTLHGLNFYLSYFDDVAKVLPREHYCFIVGGWVRDRILGEPVGYNIDVDFLTTADPVELAKNFAKRIGGHFFVFEKRGFLIKRPTIASVVLHLPPYRYRFDFSPLKGKDLEKALIEDLKERDFTANAIAVNLDDVLSIGAKQTIVYDPTGGIKDLEQGLLRPVSIENLKRDPVRVLRGFRIAIEKNLQLTEDFYEFVKEDPRIVLKSAVERITHELFKIMKEKTAHKVIRELYEYGVLEAIIPEIGRLREVKDQGEHHIYPLDEHTLKTLEYLEQVIEDRAKYLSAELLENFGKKRVLGEFTDVELLKWGALFHDIGKPQTFAVREGKVTFYEHDKVGAQIVREIGERLRWGDEATEFVAKLVRHHLRPFFLREAFKKGELKRRGMANFWRECGDIAPHLFLLSIADAMASGDEEEDIKALMETIAELESFNRNEMKEEIQKPLLNGDEIMEILGIKPGKIVGILKKALLEAQIDGKVETKEEAIEFIKRSTKNLKPLDEG
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Subcellular Localization:
Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
Sequence:
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
The following text describes a protein:
Function:
Acts as a receptor for cephalotocin.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MYQAMEVESTSPSGFFLDFYTQSTIPTTDFLNNTNSSHPIRDEKLVKIEIAVLGTCFTLAIINNLCVLLVLLWRRKKVRRMQMFILHLSIADLIVAFFNILPQLIWDITFRFMAGDAMCRFIKYAQMFSLYLSTYILIMTAVDRYRAICHPLSNQTWTPCMVYCKIFIAYAIATIFSIPQAILFQMQEVNEGSGIYDCWVHFEPAWVLTAYALYIFFALYLIPILILFFTYGSICYTIWAKYRHAIKTKKDANTRYPQRRKKKGVILRTHSVHGFSKAKLNSVKLTFAVIVTYIICWSPFFVSQIWWLFDETVVGNAGVVVILLMACLNSCTNPWIYLIFNRNYISNVLPCKCLRRHRVEVAATTETERLSLGSVRRDSRKTSDPKRISESRRISDARRISGKTQKNNSSSPRKTSDQFIYSDKTT
The following text describes a protein:
Function:
During meiotic DNA recombination, binds to and may help activate DNA double-strand break (DSB) hotspot sites.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Note=Localizes to chromosomal double-strand break (DSB) hotspot sites during the meiotic cell cycle.
Sequence:
MVKGSVTNTSSIVKQFEKSSIKHETETIAFAKQFINECIREFQEQKDNVVEEKNTDQNHQNQNQEGVIIEIYQELLQKVDLISSELRQNLSSLQLRFQEVERDTGHDLLNVLNSLSQEARLAQKVLEEDGSQQGSQLIQGLLTCFQSTGN
The following text describes a protein:
Function:
Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
Sequence:
MSVFSKVRNFFSRHRNKFIVGGVIIGGSIFLTRYAQQKLREWQEKEALEFLDRNRKHQHFESIGRTCNQTILNLALALNETISKNINTEEVIERLKTNPENKLALWNELKVLVFNKAACTIYANVMLVVTLKIQLSIIGGYLYKDPTSLSSEMQERYLSLCQNLMDAGFSRLSRLVETNCRKVLEPVNLTKQLKLSDLEALFWSIQTAVATHNDNPVENLRQYVLPELPVSDGIYEKMVKETAELLNSDEVKALVTHCTTRGFMVLAEQLSEFYTSNGVKENGKLPEGDEFTNPFNVKKPMAKVLPIMNGLFSKKSLPDQFLQQLIVYEKLQLLSANVYESFLS
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MREALEADLRAVLNGALNMLGTVERMLPVAAEVLLHERADLLGEVRSLDREVDAQEAQLEAECLRIIALHQPVARDLRLVALILKSLSDIERMGDYVVHVAEDGAELAQAPALKKYVNLSRMLSRLTEMSQNLRTSLADRDVTRAENTTRMDDEVDELYEQIQRELVTYMLEDPRNISKALMLMRVGRSLERVGDHMENVAERVRYWVTGSRE
The following text describes a protein:
Function:
Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion intermembrane space. Peroxisome matrix.
Sequence:
MGQGLSQPAQAVEEPSPPAVEAAPSSSPSPAPAPSSLEALAAEAMSFDEDGNESIDVKVQKALDCPCVAELKNGPCGSQFVDAFSCFLKSTEEEKGSDCVKPFIALQDCIKINPEAFSKEILEEEENDEEAEKSNLKVRAPAWSRESKPKL
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MDFNSSSMELPKSSSALSSDMQRPVHMQKSMPSDKKIQQDEDERDPRFMLKEELSCFWKRQKEEILHSDLKRKHELPISRIRRAMKSNDQVKMVSAHSTVLLAKAIEMFILELTRRAWMQSEQEKRRTLKRCDIARAIRNEELFDFLSDIVPLQNYKVQEAANDVQGNELHPAHQMVKPNNNSVHAEANDGQGNEFRPTHQLVQPNNIPVQQQTNDGQGNMFDPAHQFVQPNNIPYQFQVKEAANGGQGNEFHPVYQMVQPNNIPASFTSTQGIPAPLMSPPLFNFSPEDEFIIDGFLMDYKEGL