lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation.
Subcellular Localization:
Nucleus.
Sequence:
MGVRGLQGFVENACPGARVEVNLRDVAEEYRSNHPGRTPVMVVDALGCLRYWYSPESWVCGGQWREYFSVLRGFVEAFTAAGIKLVFFFDGVVEQTKRNEWVKRRLKNDKEIARIFQAIKRDGQQPGRAMFFLPSGLATFTRFALKSLGQDTLCSIREADYEVAAFGLQNDCLGILGEDTDYLIYSTCPYFSVRNLRLDRLTTVMFSREQLCRRLGLHKTDLPLLACLLGNDTVPEGACAALRERCLAYRSCTAQPAADGRSAAVLAVASFISGVLRGQQGARDLGAMVPSGPDPSLLCRGVESYLLPGQDSPWLLQGPNRATAGAEGGATPCSDPEILQVAKERHVRSESYLVYNVLSCGEAECSNTLEDALDAELPAQALVYRPARQRLYWVMLGAGRDPCEARPAVKEWFVHARNPLRHPELIQPVQPDIPGGTPSLRTLWLLQEPGARAQRYSTFLACFGLPTMAPEAEELQALEGSLAATCCLLSYLLLQVGSLSLEDLNAFIAQTLCLRGKSAVQLADLQLAYVDSRAVHLGSLFIRGLSTLVLANSTCGGPFRMDDLMPWQVFDGKLFQQKYQQSHSGQSPHELLEGNKLWLTEFQHLTSLICKTCNMKNRTVLSRQRGVVFNTGVQERMWESHAQLSWQPHSAPPRHRPDRSLPGRGPLPSPAGSPALHPGRGFRSQERGQRRKRFPFAPW
The following text describes a protein:
Function:
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and theiler's murine encephalomyelitis virus (TMEV). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
Subcellular Localization:
Cytoplasm. Nucleus. Mitochondrion. Note=Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis.
Sequence:
MSIVCSAEDSFRNLILFFRPRLKMYIQVEPVLDHLIFLSAETKEQILKKINTCGNTSAAELLLSTLEQGQWPLGWTQMFVEALEHSGNPLAARYVKPTLTDLPSPSSETAHDECLHLLTLLQPTLVDKLLINDVLDTCFEKGLLTVEDRNRISAAGNSGNESGVRELLRRIVQKENWFSTFLDVLRQTGNDALFQELTGGGCPEDNTDLANSSHRDGPAANECLLPAVDESSLETEAWNVDDILPEASCTDSSVTTESDTSLAEGSVSCFDESLGHNSNMGRDSGTMGSDSDESVIQTKRVSPEPELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMASIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNDSDKSDDEASSCNDQLKGDVKKSLKLDETDEFLMNLFFDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYALSQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKALQKKFADYQTNGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCLYSDED
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MGSENPDDFEPAVVLVDDDQQEIGGLINSDGEEVEFADLRLNALSGVVHSDVSSKKSDPIDNDKPLHSCLVCGKDFPYASKLQRHLRTHSGERPFPCSMCEKRFPEKGLLMIHERVHTGEKPFPCTFCEKRFASQGELRLHRRTHTGERPYHCSICLKSFSRHWHLKTHLEAMHSEIVEGFTRKKFPCSECEKSCNSAAELRDHQRTHTGERPFQCSFCDKRFALSGTLVRHERLHTGITPYHCSDCGKTFAQQWTLTTHMRTHTGEKPYSCTQCDKSFVAPGELRRHVRIHTGEKPYTCADCGRHFSLAGTLRNHKRSCTHSKSDPVEASVKESTQQDLESNISCKVPDDQHLPRIDEPPSIESLNSSKDAESEVQHGEEAEKAANSPSTPQMNVIVKEEEEDELLCAEESPQQVSDDQNDSISEETEEQHESSTEIRIAVKEEEEEHDKVSGEDPDCQKDRLPDSPVQKQSHSHPKKTYCCGLCGRDCHKMSALQIHMRIHSGEKPYQCTVCGKQFTQKGQLKGHFKVHTGEKPFSCPECGKSFAHSGAMNRHRLTHTGERPFHCSVCDRRFNQSGRLREHEKIHFGEKFDCPECEKSFTRSSSLKNHFRLHTGERPYHCDLCGRGFSRSQSLRLHRRKHQQVQSDMDSSANVTNDDFSHSDNNSPVNMCTTDRRD
The following text describes a protein:
Function:
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin (By similarity).
Subcellular Localization:
Cell membrane. Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MPYEIKKVFASLPQVERGVAKIIAGDPKGNNFLYTNGKSVIIRNIDNPAIADIYTEHAHQVVVARYAPSGFYIASGDTSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGSVFLWDTGSSVGEIIGNIKVINSVDIKQTRPYRLVTGSDDNCCAFFEGPPFKFKFTMSDHSRFVNCVRFSPDGSRLASAGADGQIFLYDGKTGEKVCSLGGSKAHDGGIYAVSWSPDGTQLLSASGDKTAKIWDVAANSAVTTFNLGSDVLDQQLGCLWQKDYLLSVSLSGYINYLDKNNPAKPFRIIKGHNKSIQCMTVDKSDGRSTIYTGSHDGHINYWDAETGENNTFTGKGHTNQVSSMDLDGSSQLITCSMDDTLRYTNLISKDYSSSESVKMDVQPKCVAVGSGGYVVTVCIGQIVLLKDKKKVFAIDSLDYEPEAVAIHKGSGTVSVGGADGKVHLYSIQGNSLKDEGKTLPAKGAVTDLAYSPDGAFLAVTDANKVVTVFSVADGYSEHNSYYGHHAKALSVAWSPDNEHFASSGMDMMVYVWTLSDPDTRIKMPDAHRLHHVSSLAWLDENTLATVSHDACVKQWTVTFK
The following text describes a protein:
Function:
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
TETPVTGEQGSATPGNVSNATVTAGKPSATSPGVMTIKNTTAVVQKETGVPESYHQDFSHAEITGIIFAVMAGLLLIIFLIAYLIRRMIKKPLPVPKPQDSPDIGTENTADPSELQDTEDPPLTSVEIETPAS
The following text describes a protein:
Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MADIDRQWEDLRRDARKIEGDLDVKLSSYAKLGGMMSHGSALGTSPDLASDGSWKSMEMEIESLLTRLLDINESMSHCVAAATSTASLAQKLARHREILHDFSQEFKRTKNNINSMREHAELLSSVRNDISEYKAQGGPTSGVGGLLRERGQIHSATASADEVLAQAQATRSALTAQRGLFVEIGAKLKHLGDRFPVIRSTLTAIRRKRSRDTYILGSVIAACTVFLLLYWLSK
The following text describes a protein:
Function:
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLKFQEATKCVSGSIAVSTCPRPLIARRYALLQKLGSGSFGTVYLVSDKKAKQGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDYKIQEYKEAGRTFPESQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFTGSNFLSIVLKIVEGDTPSLPERYPRQLNTIMQSMLNKSPSLRPSAVEILKIPYIDEQLQHLMCRYSEITLEGKNLNCQKEAAYIINAVQKKMHLQTLRALSEVQKMTPRERMRLRKVQAADEEARKLKKLVEEKYEENNKRMQELRSRNFQQLTVNVLHEFDDRASENLPESQPILFPDLGALGSSMEDTAADLGDHEIPEDPLVAEEYYTDAFDSCSEESEEEEENMVFSAGEEEVQDEGSQPAYRTNQQDSDIEALARCLEHVLGCTSLDTRTITSSAPDTSSGPTIFNSAVARTKMKRMRESAVQKLGAEVFEEVYTYLKRARQQRASEAEVRAALETVVPRASDCFEVDQLLYFEEQLLITRGEGATRQNHQEGTIRDKQL
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MTDMDSVHLLEISFESENKLEPERKTELAKKLGLQPRQVAVWFQNRRARWKTKQLERDYDLLKSSYDSFRSSYDFIAKENERLKAEVASLTEKLQAKEVVESSFHAKNPDPFLEDQLLVPVVQQSIKIEDHHSCRSNGSAVLDEDGPHLLDSGDSYILSNDYDGCVLPTFGVNSEEEDVSDDGQGYFSDVYTTVDQQTHEGEPLTWWDWTS
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTEEEKKRLQVLERDAETAYPFLASDEKSSTFKTAEDLESGINPLVSIATTNESQQKLDNVSSISTTTNEKPKPKPKPWVHFVAGGIGGTVGAVVTCPLDVVKTRLQSDVYHSMYNKIPKSGNPIIQAWQHLSETGSVLRGMYINEGASSLFKGLGPNLVGVIPARSINFFTYGATKEFLLGNFSPTNSIQGPRQEETWIHLVSGINAGFVTSTATNPIWLIKTRLQLDKSKGKNYKNSWDCFKHIIKHEGFTSLYRGLSASYLGGIESTIQWVLYEQMRMFINKRSLQIHGNDPSNKTTKDHILEWSARSGAAGLAKFMASLITYPHEVVRTRLRQAPLESTGKPKYTGLIQCFKLVIKEEGFGSMYGGLTPHLLRTVPNSIIMFGTWELVVRLLSEW
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MSWHFVERWLQKVNQHSTLIGKFWITFLIVFRIVVVSSVGDRVYSDEQSEFKCNSMQVGCPNLCFNKFSPISHIRFWSFQIIMVTTPSIVFMVYSAHQLYSSKRKMRKRKEKSNFGFYKLVEMFGEEKAAFSQHYVLYTSSVLMRTLVEILFIVLQYRLFGFRVSELYKCTGDPCPNIVDCFVSRPMEKTIFLWFMFVIAVICLALNVGEMYYLLWQFGVRRSRLERKRKRYRRSTISEVRGANLADAEILDGGVFPVPGAPP
The following text describes a protein:
Function:
Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species. Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity).
Miscellaneous:
MISCELLANEOUS: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency; MISCELLANEOUS: This protein is inhibited by dicoumarol.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MAVRRALIVLAHAERTSFNYAMKEAAVEALKKKGWEVVESDLYAMNFNPLISRNDITGEPKDSENFQYPVESSLAYKEGRLSPDIVAEQKKLEAADLVIFQFPLYWFGVPAILKGWFERVLVAGFAYTYATMYDKGPFQNKKTLLSITTGGSGSMYSLQGVHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARVQVLEGWKKRLETVWEESPLYFAPSSLFDLNFQAGFLLKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK
The following text describes a protein:
Function:
Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.
Subcellular Localization:
Cell envelope. Membrane; Lipid-anchor, GPI-anchor.
Sequence:
MRLSLSVVASLAMSVMAQTYTDCNPLHETCPADKALGTSKSFDFTQGPSDDFPPSFKPHRITYSNDTGVSLAVVEQGDNPTIQSDFYIMFGRVEAVVQAAPGQGIISSVVLQSDDLDEIDLEWIGGDANNVQTNFYIQGNTTTYDRGAIHPVANSNSEFHTYTVEWTKDDLTWFIDGEAVRTVPSTFSQGYPQSPMNIRIGVWAGGDPTNNAGVIEWAGGETDYTKSPYPMYVKSVNVQDYSTGSEYSYSDHSGTWESIVAKDGEVNANAPVEEVPEETTSAVESSIPVETSAAVESSAVESSAVESSAVESSAPITSAPAPVSSAPAFTNSTISTGVSSGAVVTVEATEHVESTLTKTVTHCEDNKCVSKPQPTVTVTKHCTLDKCVSKTIPVEYVTVTATTTKVVTEICPEAKCHKISSVPVRPAPTEAPLKPTNLKTTQTVTKTGTVVVKTDTPKSEPASEVSKPTTESKPTAESKPTAESKPVAKPTGSSPVEVPAEGKSTQTIHLTQIVTIGTQTVQTVIPQSDIPTAAPQTSPVVQVNNGTVPQVPQAPNTFPAQANGAASKAVSVVAAMVAMVALLI
The following text describes a protein:
Function:
Master transcriptional regulator of the unfolded protein response (UPR) that recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes. In the canonical UPR pathway, the ireA RNase splices the cytoplasmic mRNA hacA, which alters the reading frame to allow translation of the bZIP transcription factor hacA. Induces the expression of pmrA, scrA and spfA in response to UPR.
Miscellaneous:
MISCELLANEOUS: [Isoform I]: Induced and active isoform; MISCELLANEOUS: [Isoform U]: Not translated. The unspliced HAC1 mRNA is stable, located in the cytoplasm, and is associated with polyribosomes, yet does not produce protein. Translational attenuation is due to basepairing of the intron with the 5'-UTR of the mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MEDNFASVVESLSGTSASALPLLTVSPADTSLKAPETKVQETKTEEKKPPKKRKSWGQELPIPKTNLPPRKRAKTEDEKEQRRIERVLRNRAAAQTSRERKRLEMEKLENEKIQMEQQNQFLLQRLSQMEAENNRLSQQLAQLTAEVRNSRNSTPKPGSPATASPTLTPTLFKQEGDELPLERIPFPTPSITDYSPTLKPSSLAESSDVTQHPAVSVGGLEGPGSALPLFDLGSGVEHDAANDIAAPLSDDDFHRLFNGDSSTEPDSSVIEDGFSFDILDSGDLSAFPFDSMVNFDSEPVALEGIEPAHGLPNETPYQTSGLQPSLGASTSRCDGQGIAAGC
The following text describes a protein:
Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MFPVAPKPQDSNQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSRQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLNRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQQETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELISHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQSKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWHNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPNFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYARLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFRAFTNDLLEILEIDDLDAIVPAVKKLKVLSY
The following text describes a protein:
Function:
Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MGDKFSVPTNQSKERQPIVKKKKKKKRTNIYSYILIISFPVIDQFQMSESLNIQELTDNSSIIPIPTESTDVQDVTSVSNKDTTTTTTTTTTTTESTTRVRKSSPSPSANENDKKRLKKEFQPRQKIEYTPLVDENGQPIPKAPRKPKRKVAVMLGYCGTGYNGMQVQNDPNVKTIEKDIYDAMATAGAISAENAVDLKKSGFQRAARTDKGVHAAGNVISLKMIIEDPEIINKINDLLPKQIRIWGIQRTTKGFDCRKCCSSRIYEYLLPTFSLLPPKPKSVLSELVKEKKLENPDLFEDDQEGIDWWENVKSKILASGITQEQIDSITSSYDEQQQQQQQQQQQQADEEERDISELSFTKLIKQIKTIENQSRRSYRISSSRLQHFREVMKQYEGTHNFHNFTVGKPFKDTSANRFMIKTIVSDPFVIEGTEWISIKIHGQSFMLHQIRKMIAMAALVVRLSLPCGIINNFFQSTKINIPKAPALGLLLENPVFDGYNIKLTKSDYEPIDFTKFDKEMNEFKMKYIYDKIYAEESKENIFYGFFGYIDAYRGNKNEDGEPIQNGASIFDFLFNYTERVENTKNKDAKNTSKTEESKPEESKPEESKSEQS
The following text describes a protein:
Function:
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVSDPAGPRCFCRDCLVDLDMGVRRCSACGSPRLVRHRALSSLTIAHIDCDAFYATVEKRDNPDIADKPVIIGGGKRGVVSAACYIARTYGVRSAMPMFKALDACPHAIVIRPDMAKYVRVGREVRQAMQALTPLVEPLSIDEAFLDLSGTERVHGMIPAKVLARFARNIERDIGISVSVGLSCNKFLAKIASDLDKPRGFAALDQEEARLMLASRPVGFIFGVGPATQERLVQRGFRIIADLQKADEIEMMRQFPSDGRRLWRLARGIDDRRVEPDRGAKTISSETTFETDIRDFATLEKILWRLCEKTSSRLKSSELAGSTVTLKLKTADFRQRTRSQSIAAPTQLAAKIFSICREMLAKEIDGTAFRLMGAGVSALREGSPADDTDMLDRRAAHAERAVDSLRKKFGNSAVIRGIAYDGPETGQQE
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDYSQFLHMREELSLVAVLLLLFLADLFMSPDAHKQKGTRPVLNTMLPVILMAIHTAINLVPGTAADIFGGMYHYVPMHTVVKSILNIGTLIVFLMAHEWMKRDDTSFKQGEFYVLTLSTLFGMYLMISAGHFLMFFIGLETASIPMAALIAFDKYRHNSAEAGAKYILTALFSSALLLFGLSMIYGSAGTLYFDDLPAHIDGNPLQIMAFVFFFTGMAFKLSLVPFHLWTADVYEGAPSTVTAYLSVISKGSAAFVLMAILIKVFAPMIHDWQEVLYWVTIASITIANIFAIRQQNLKRLMAFSSISQAGYIMLGVIGGTAQGMTAMVYYILVYAAANLGVFAVITIVALRSQKFTLEDYAGLYKTNPKMAFLMTISLFSLAGIPPFAGFFSKFFIFMAAFEAGFHLLVFIALVNTVISLYYYLLIVKAMYIMPSDNPIPTFRSDRCTKWGLALCTLGIIGLGIASIVYQSIDKLSFGI
The following text describes a protein:
Function:
Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression.
Sequence:
MLNNIGLKYFVGVAKVGSIRKAAEQLHVAASAISRQIQLLEDEIGAPLIERHRGQKTIKLTASGELVLEYARLMDNELDELRAQVRAIDSLQRGSVRLGVSEGFTRAFLPGFLQRFRTQYPGITFQVTTYGAVRLAEMLVEDIVDIVLAYGVPESLDVRVAKQVFFRPCLLVPVSHPLAARRAVDLSECADLEFAFPDETLSTRSEYVRMFAKAQVKPRLVITTNSYELTRAVAAAGGCVAIVNRDPGREQPPRGTRYVPLKGDGVEQWPLKLCVHTGRSLSVAARLCVDQLSAAIDAEHCD
The following text describes a protein:
Function:
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
Subcellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein; [Isoform 3]: Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MAWALAVILLPRLLAAAAAAAAVTSRGDVTVVCHDLETVEVTWGSGPDHHGANLSLEFRYGTGALQPCPRYFLSGAGVTSGCILPAARAGLLELALRDGGGAMVFKARQRASAWLKPRPPWNVTLLWTPDGDVTVSWPAHSYLGLDYEVQHRESNDDEDAWQTTSGPCCDLTVGGLDPARCYDFRVRASPRAAHYGLEAQPSEWTAVTRLSGAASAASCTASPAPSPALAPPLLPLGCGLAALLTLSLLLAALRLRRVKDALLPCVPDPSGSFPGLFEKHHGNFQAWIADAQATAPPARTEEEDDLIHPKAKRVEPEDGTSLCTVPRPPSFEPRGPGGGAMVSVGGATFMVGDSGYMTL
The following text describes a protein:
Function:
Involved in the presentation of foreign antigens to the immune system.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKNREPWVVVLLLLLVTMDLTQYCAGSRWLQTFNTVIAEPRKSAHQFIQVSYVDSIQFQGFDSQAPNAKMRPRAAWMEQEPPEYWEKGTAQAPRLSLTNQRVLQFLVIENKHSKNEYHTLQELFGCNVANDGSFLRGQYRLTYYGYDNIILNEDLSSWTTEGSAAQDLMKYSETGGMAEMPPKTHLTHQVRPDGNVTLRCWALGFYPADITLTWQRDGKNHTQDMELPDTRPAGDGTFQKWAVVIVPSGEEQRYTCHVHHEGLPEPLTLKWEPSTTIPIMAILTGLILGTLVMGTVVYLLVWKK
The following text describes a protein:
Function:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
Subcellular Localization:
Nucleus.
Sequence:
MSLSLEDFKQEFAEWDLVFPVNLYDKIKEVCEKYDLSAEDFVSSWQAHKQNHKIKVNLNLEHLDFFAREEFEKKFVKKSSKVRSIPKTPIVNNHEANTPASSKKRPIDITPEMANKKIILSEEDQFVGTPSRAPSSLNGMTPSAKYSSRKNKGEVVASNCENSLNDRRLWRRQDVNRLVTVLDYEEAREMKPHCKYMFHRASEKYYTLNFMISDMQQRLLSTGVVEEFTSIGNVFQDPQIVIGRVNFDVMDKQLSLEEENTGLTVPLSLNSLADYFIFTGQVAAFECTNPTGKCLNALRFIEPVYPPQPPLKDFKDLSVLVACGPFSTQDSTMYEPLNDLITQIEQNTPDLCILLGPFIDTEFAELQINEDLGSLQQNCFNKLKEMAASLHCHVVIIPSQRDFLHEFVYPQPPFKLSSSSFVSYMSDPCTLDVDGLVIGVTSTDVLMHMSKDVISKSQKNVDRFTKLVQTFLGQHNFYPVNPPSNEVNVDLELFDVYAKLTVTPHLLILPSELKCFVKTVNCCTCVNPGKLSKKEAGGTYAHIKIRANAPAVNVGENSPGNIENNVTCEVKVVKI
The following text describes a protein:
Function:
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for the translocation of the multiple pectic enzymes.
Subcellular Localization:
Cell inner membrane.
Sequence:
MNISKLPPLSPSVIRRILFYLLMLLFCQQLAMIFWRIGLPDNAPVSSVQITPAQARQQPVTLNDFTLFGVSPEKNKAGALDASQMSNLPPSTLNLSLTGVMAGDDDSRSIAIISKDNEQFSRGVNEEVPGYNAKIVSIRPDRVVLQYQGRYEVLGLYSQEDSGSDGVPGAQVNEQLQQRASTTMSDYVSFSPIMNDNKLQGYRLNPGPKSDSFYRVGLQDNDMAVALNGLDLRDAEQAKKAMERMADVHNFTLTVERDGQRQDIYMEFGGDE
The following text describes a protein:
Function:
Negative regulator of cell proliferation in the adaxial side of leaves. Regulates the formation of a symmetric lamina and the establishment of venation. Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV. Interacts directly with ASYMMETRIC LEAVES 1 (AS1) to repress the knox homeobox genes KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3, KAN2 and YAB5. May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis. Required for the binding of AS1 to the KNOX genes. Involved in leaf polarity establishment by functioning cooperatively with RH10 or RID2 to repress abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial development in leaf primordia at shoot apical meristems at high temperatures.
Miscellaneous:
MISCELLANEOUS: Gain-of-function mutants iso1-D and iso-2D (T-DNA tagging) show completely curled up hyponastic rosette leaves.
Subcellular Localization:
Nucleus.
Sequence:
MASSSTNSPCAACKFLRRKCQPECVFAPYFPPDQPQKFANVHKVFGASNVTKLLNELHPSQREDAVNSLAYEADMRLRDPVYGCVGVISLLQHQLRQLQIDLSCAKSELSKYQSLGILAATHQSLGINLLAGAADGTATAVRDHYHHHQFFPREQMFGGLDVPAGNNYDGGILAIGQITQFQQPRAAAGDDGRRTVDPS
The following text describes a protein:
Function:
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MEFLSKYTACLSNWGLNLEPGLQTVGAAVLLTTGTLFIASRVLTFVRVLLSLFVLPGKPLRSFGPKGSWAVVTGASDGLGKEFSLQLARAGFNIVLVSRTASKLTTLAEEITTKHSVQTKTLAMDYAANNDADYEELKAIVDGLDVAVLINNVGKSHDIPTPFALTPEDEMTDIVTINCLGTLRTTQLIIPGMMQRKRGLVLTMGSFGGLLPTPLLATYSGSKAFLQQWSTSLGSELEPYGITVELVQAYLITSAMSKVRRTSATIPDPRAFVKAVLSKIGRNGGSPGYAYSSSPYWSHGLMAWFLTCVMQPMGKLVVGQNKSMHEAIRKRALRKAEREKGKKST
The following text describes a protein:
Function:
The imp locus inhibits the extrachromosomal maintenance of the Streptomyces plasmid SLP1.
Sequence:
MAPKAPKWRELADRFAEQIRTGDYGPGEQLPQIRDLVEAGEGSKETVHRAYKALETEGLVAMSRGHGTVVRRKAPLKRLGIGRYDKAKWRDGDEVAFIADRVASGRSYRRNEQTQTVSRVKASAAVATALGLPEGADVYARARLVKEGTQPTHTLTSYYRPEHVEGTRIVDPTPGPAGRGGGFRVLYDAGYEIDHMTEEIFARVPSAEEAQLLQLAPGEWVVELHRTTRTVDGTVVEFAIGVHAGTRFAWSYDFKVPDSAMTEAEDESK
The following text describes a protein:
Function:
Together with CGF1, essential protein which supports female gametogenesis and embryogenesis, probably by securing local energy supply.
Subcellular Localization:
Plastid, chloroplast membrane; Multi-pass membrane protein. Plastid membrane; Multi-pass membrane protein. Note=Present in chloroplasts on green tissues as well as in plastids of roots and seeds.
Sequence:
MDRLLQPPSSHSIAPSKFQSRPSPLLLHRLHSTNLSTFPSSRRLESRRISSISCFFRQNPSPDTSPGLNQSSNFLIASSQTDASKPNPGFIQRIVSSFEQRKTISAGMVILVSAIAALLLNPILVPPAFASFQTATNSGGAAVVGGKLLRTEVLTSAWTGFFAGCLHTLSGPDHLAALAPLSIGRTRMESAAVGALWGCGHDAGQLIFGLLFLLLKDRLHIEVIRTWGTRVVGLTLLVIGAMGIKEASEMPEPCVVTLENGETDEKSLKKKKIGFATFATGIVHGLQPDALMMVLPALALPSRIAGASFLIMFLIGTVIAMGSYTVFIGSCSEALKEKVPRITEKLTWASSLVAIGLGLAIIVSQFFGFSLY