lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
Sequence:
MNDNDDKPIATTIDNKSHNPIILPVVNPSREPEVLVFNVDDIKTLRNEYNILGVLMGTLQHYPQQNIFLSVPLKLIIWEVIWLLQYNKAILVDHLTYRDAKIKLLKGDIKNNNYQGNLITTPNSDNDYNLELAKQHQLTIYDYITNYLQDSSMSVNQFITYYKYYSYLQNKGYFINPGIKFGGDLVIYPGDPLRYHSYSIVRFEFFDVHDVVVGGRLATSVKKNLVLMGYDQEADKTHQEVNEDVISDLFDESVPLTFSIEWAGFG
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MFNDDASHHVITNNSSNGMNSFTLFNDLTYSDDEDTDNWDGGETGERSFSSPDAAEAAALLDDIQTSIFASSQLPMHPLAREDSHVSDEGSYLAYSVSTVPGEEESKLSSYGSLETQPLEYFKQRTNGNAVVFRPSSLGFDTRHHEQGQQYQHQYQQSNNSATTSCYQSASSTRQHYQLYPPTPLPTTIVEESPVTSGTATDVTISPSTIADQNQKPNPEKERITRLLSEEATKKLRRHKRLKRIKKAAEAREAAVQKVRGTEQTTSCNDAIFAFVFMCHLMLVCVSAVVFGPGNLRDKIYGSLEMQGGRYHEDEDYNPFAGLQSDDVIIMYKPTNTADSSEEMTSVEENSPSISHIDYVNVIQLVCITSGYASLCSLLALGFMMMLSKSLLHVTLIFTIVVSTAWALLGWAFSSYRFIPTIGILALTLSFVYTIVVWDRIPFAATNLSVALKGMRSTLDIPFTGICVLMVSFLWTIWWICAFVGVFDFLNDDAELSDGWMAVVVGFFLFSYYWTIQVIKGTAQATVAGIIGQWWSHEDSLPMCSDAFRRSLRRNLMLSFGSICLGALVLDPCVVFYRVANFIRLAKPKLCHLKQPSLPTTKSSKAQDPATTICGSSFFTNNVMYRNVNQWSYAYIGLYGYNFWDSGNKASQLFEARGWTHVVSDDLILTALSMSSCVIAGSTACLGLIVEEVDGFSFTTLNKPIVTAFLIGLFVGYCLSSAFFSIIEGSVNAILVCYASAPVDFHANHHLLSEEMKSVWKEFWLSRGG
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. Regulates both flower and shoot apical meristem (SAM) development, especially for establishing organ boundaries in shoots and flowers, probably by controlling the number and position of WUS-expressing cells.
Subcellular Localization:
Nucleus.
Sequence:
MGFSMFFSPENDVSHHSSPYASVDCTLSLGTPSTRLCNEDDERRFSSHTSDTIGWDFLNGSKKGGGGGGHNLLARRCANCDTTSTPLWRNGPRGPKSLCNACGIRFKKEERRASTARNSTSGGGSTAAGVPTLDHQASANYYYNNNNQYASSSPWHHQHNTQRVPYYSPANNEYSYVDDVRVVDHDVTTDPFLSWRLNVADRTGLVHDFTM
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MILEQKQSDYLKQWMVQKLKPICDADHEVLSEYVMALLRHDQSENQLRSSCLKQLEDFLQQDTKLFVTDLFDHLRTFGAFNGSYQPPEINLSASVLLRKRSLAVDEPYLLPNNNQLDNQHRPSQSSTAPIPQYTPTQSHPSFLHFPEPQSNLINPLPSFNPSSHTQQPPYNNTNTNQPRNSKRPRRSICRDYHYRGYCARGSSCHFSHDDRDQDASSSSTQSSAYFSKTLPAETQPTTAPPSATCIPLVFSSTSVGQQIPGLGGPLTIPYDLPIPSFSSSNPPEQQSGNDQSNHYNSRHPDRSTRFNGPTSNTRKPFTTLFIENIPQSSLSDRAVREYFSMFGPLTNVTLDVHNSQAQVTFKSTDDAKRAYSSPEPVFNNRFVRIHIKRVVGTGPRRSHGPLRTDASPAAEGFSNNESSYEMNSNGYRHKAYDSPITYKSPPVSSPPQPKADVQVLSQREQELRLKIDAQKRLLEQLSLKKAQKSNGPTQDIEMSGPSKPTAQLDTENQPKQDLPKTDPNSTDLSESATTDTKLLSPEPRLVSPKEALSPLPEPNSFQKRPANFASRAVGRTKLTNSRTSWTPTGSSPTKAFKLDNRSCTLAVQSVPSSTARENLKVYLEQFGTIVAFVPLSEEEDMFDVSVKFSTRTAAEKALANGLDIPDVGKVTMNWVPVGAGSGPSTTAKTTTTTTNNATGHPQHIFIPGLRNSHHHHYPGSFSLVNHRPGAQSKAEDPTTGETGDKKSMAPDSSLTTHTRGGSDNLLVNGADTDDLIDDFCVDDEVDGCWKR
The following text describes a protein:
Function:
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Sequence:
MVDICWEQLHRSAIEVRQNAYAPYSHFLVGAAGLVDDGRIVVGCNIENASYGLTLCAECGLVSHLIATGGGRLLAVVCVDSQDNYLAPCGRCRQVLLEHGGKELQVMTPTGPLPMAELLPWSFGPQDLRRVGGLNTNP
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MREEVLKRILLIIGAILMAIICLFPFIWMIVVSFAEDPTFLGSPLVEYKSTLENYVRVLSDPTLHFPAYLKNSIIIASLVTLTTVSISSLAAYAVSRIEFKGRLLIPIFVLGLSMFPQISLVGYLFKFIEKLGWVNTYQALYFPYVAWTLPLSLWILLSYFSQLPKDLDEAAMIDGASRIKTLTTIILPLSAPALFSTALLVFIAAFNEFMFALLFTTDHRARTVPVGIALFQGVHGEIPWGSVMAASVISTIPLVIMALLFQKYIVSGLTAGALKGE
The following text describes a protein:
Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Sequence:
MGTAEGDNLSPLIPIPTKNVDKKCEMCEQDSSKYTCPRCQMKTCCLSCVKNHKSQRGCSGVRDKTPYVPIKEFTENHLLNDYRLLEDMDRKRYAANGDVKNKPGYLNFRWKLVSKKAADRGVRLRLLPHFFSKHKENSTTFIKKTKLIAWHVKWIFPKSSAEFTDTRLSEEVILREALDKYLHPDRADPVIRQRLKKYCSKGIDDVEVYMKVEDKPANTVRYYSLALDKTLGANLKGKIIVEYPTFHVTLRDDTEQYQLLDHEKMDQSRVAVENNSQSVNTLEQEKEDGEDEGPPEETTSHQIDDAKSQSVNTVEKEMEDGEDETPPEETTSHQIDDAKLQSVSTVEQGMEDEEDETPPEETTSRQIDDLKPQSLSTMEQERKDGDADEGLPEEISSHKMNNTR
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MNAKLSSSGMVLKELPEVALQKISSNYYWAVFAVFLLCAIVFPLVSIFSLPQKQTYHRFFSILSLVSCLAYFTMACNYGLKNVFSSASFFREVSVRMVYYVRYIQWLINFPLIIVMLHWTVGVSILEIAYVVCYVLFAIVCLLAAALTSSPYKWAYYGFSFVGYFIALAHSVVLHKKYASRLETSARLGFLWSIVYLHVIWFLYYACWILSEGLNVISPIGEAIFYSILDLFEFGFFGAAFSWMLDLVGIENFKSPQSIPLGACSPADDKFSMCPDMEAQNQADDLAVETRIQISNLPSSPTKNNC
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MGLKNKIIKIYELNEEERKKVLEFLKKEILNGKIVICGTDTLYGISANALNEKAVRKVYNIKRREFNKPLSICVRDKNEIEKYAYVNDLAKKIIDKFLPGPLTIILKKKPGIPDIVAKDYIGIRIPDEPIIRELSIVPLTTTSANISGKESPTTVDEIDKEVLKKVDYVIDIGKCKYSKPSTIIKIEDDKIISIREGVIPIQKLARC
The following text describes a protein:
Function:
Putative transcription factor that appears to regulate lipid metabolism.
Subcellular Localization:
Nucleus.
Sequence:
MPQQLLITPATEATWVKLKEVSLWEDVTKMFGGEALLSHDANGTQQESLADGTTPGTPAAGSHDGATPGTTATGSHDEATPGTPAAGSHDGETPGIPAAGSHDGETPGTPTAGSHDGVTPGTTAAGSQESLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVAGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWTHKKKRQEGNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCMRARRYPCNVCEKMFKQPIHLVEHMRTHTGEKPFRCKECGRAFSQSASLNTHQRIHTGEKPFACEECGKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHRTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSRHQKIHRRNTFRDDPGHENKRQL
The following text describes a protein:
Function:
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Sequence:
MQTSSEPAASETAALLGKPLADRVMRGVRADLKAWAQLDPPFEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFRVVDLGAAATQEALEQTLRELSADPAVHGIVLELPLAAGLDADAALLHIAARKDIEGLSPANLALIAAGREPEALLPPTPRSVRFLLRHALGDDLRGLRVAVIGPGRTVGRPLLFMLNNKGATVTLCNEHTRDLAAVLAAQDAVVVAVGKAGLLRPEQVQPEHVVIDAGINVQESGDMVGDALPELPVRAQTPVPGGVGPLTSALMYQNLVRGVKLQRGEPVDD
The following text describes a protein:
Function:
Edema factor (EF), which constitutes one of the three proteins composing the anthrax toxin, causes edema in the host. Acts as a calmodulin-dependent adenylyl cyclase by converting ATP to cAMP, leading to dramatic elevation of intracellular cAMP levels in the host, thereby causing edema. EF is not toxic by itself and only acts as an edema factor when associated with protective antigen (PA) to form the edema toxin (EdTx). Required for the survival of germinated spores within macrophages at the early stages of infection.
Subcellular Localization:
Secreted. Host cytoplasm, host cytosol. Note=Translocation into host cytosol is mediated via interaction with the cleaved form of protective antigen (PA-63): following secretion, EF binds via its N-terminal region to the upper rim of the ring-shaped homooligomer (homoheptamer or homooctamer) formed by PA-63 on the host cell membrane. In this PA-63 pre-pore state, the N-terminal segment of EF refolds into an alpha helix engaged in the alpha-clamp of the PA-63 pre-pore. Recruitment to the PA-63 pre-pore enables domain reorganization of EF. Loaded complexes are then endocytosed, followed by a conformational change of oligomerized PA-63 from the pre-pore to pore state, which is triggered by the low pH in the endosome. EF is then unfolded to pass through the PA-63 pore and translocate into the host cytosol.
Domain:
The N-terminal region contains the ATLF domain responsible for binding to the cleaved form of protective antigen (PA-63). The C-terminal region contains the calmodulin-dependent activation domain and the catalytic site. This region is composed of three globular domains: CA, CB and a helical domain connected to CA by a linker. The active site lies at the interface of CA and CB. The metal ion is coordinated by residues from CA; calmodulin probably binds in a multistep fashion first to residues in CA and then to residues present in the linker and the helical domain.
Sequence:
MTRNKFIPNKFSIISFSVLLFAISSSQAIEVNAMNEHYTESDIKRNHKTEKNKTEKEKFKDSINNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIIDEK
The following text describes a protein:
Function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
Subcellular Localization:
Cytoplasm.
Sequence:
MLAGVLLLQIWLKCKYANVQFGEHGFNGDEFYLDFYINENFSTKQFAKIESDLNSLSSKLEGISQKFVSLDEALSFFENDQFTKNLLKKSNLNKFKITFFENKHFWIEDLTLTFIKKSFIKLLNVSVNYFLGDPSQLQLQRINGIFAQSKKELEQLIKENEERLKKDHRSLGKQLELFSFDPLIGAGLPIWLAKGTTLRNIIGNFVHHQQLLFGFNTVCSPVLANIELFKISGHYQHYKEDMFPAIKLDSQAMMLRPMTCPHHCLIFKQKRYSYKKMPQRFSEDSILHRFEASGGLIGLERVRCMTLLDNHIFCRADQIKSEIKNAFNLIQKVNKKFGFIFDRIDLSLHDPKNQSKFIDNPGLWRESESQMENVLKDLNIQYQKEIGAAAFYGPKIDFQFKTIFKKMITIATIQLDFLLPEKFDLTYIDKKNTLKKPVIIHVGIIGTYERFIAALLEKTSGNFPLWLAPVQAVIIPVNIQKHLKAAKKLYNKLLKENIRVNLDDNQDRLAKKVRQAIIEKIPLQLIVGDKEIENLEKLTCRGFKGEKITRISFNNFVKRVRRDG
The following text describes a protein:
Function:
Component of the get4/get5/sgt2 sorting complex involved in the GET (guided entry of TA proteins) pathway that leads to the insertion of tail-anchored (TA) proteins into the endoplasmic reticulum. Get4 and get5 form an obligate complex that catalyzes the transfer of tail-anchored proteins destined to the endoplasmic reticulum from sgt2 to the cytosolic targeting factor which then targets the TA protein to the ER membrane via get1/get2.
Subcellular Localization:
Cytoplasm.
Domain:
The C-terminal region (residues 201 to 272) is involved in homodimerization.
Sequence:
MSTVDQSTVTTALSSSSSNRHQGNDTYSIPKHSGTTSTITITMNEVSFVKSYLSTLDSRPIKLRSDHVFDPEQVGLRVPYTLPRLHAPHPEMPKKTKQPLAPGSSKSITVHLKSARNPALEFSLPNTALTTTSVQDLKDAVRERVTDAQGNKISLDKIKILYKRKPVTGKTIAEVLADEPVRLSGGKEVEFGVMIIGGAQVAVSAGAGERASAEQKESYEPPKPAVGPSGESVVATEAFWDDLQGFLEQRLKDYDEANKLRVLFKEAWRSSF
The following text describes a protein:
Function:
S-bacillithiolation is the formation of mixed disulfide bonds between protein thiols and the general thiol reductant bacillithiol (BSH) under oxidative stress. BSH is an equivalent of glutathione (GSH) in Firmicutes. This protein is a dithiol bacilliredoxin, which debacillithiolates (removes BSH) the S-bacillithiolated OhrR (OhrR-SSB) in vitro and in vivo NaOCl-generated S-bacillithiolated MetE (MetE-SSB). Involved in maintaining redox homeostasis in response to disulfide stress conditions.
Sequence:
MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTTLVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSSPSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV
The following text describes a protein:
Function:
Chemokine-binding protein that inhibits neutrophils' chemotaxis.
Subcellular Localization:
Virion membrane; Single-pass membrane protein.
Sequence:
MLTVLAALSLLSLLTSATGRLAPDELCYAEPRRTGSPPNTQPERPPVIFEPPTIAIKAESKGCELILLDPPIDVSYRREDKVNASIAWFFDFGACRMPIAYREYYGCIGNAVPSPETCDAYSFTLIRTEGIVEFTIVNMSLLFQPGIYDSGNFIYSVLLDYHIFTGRVTLEVEKDTNYPCGMIHGLTAYGNINVDETMDNASPHPRAVGCFPEPIDNEAWANVTFTELGIPDPNSFLDDEGDYPNISDCHSWESYTYPNTLRQATGPQTLLVGAVGLRILAQAWKFVGDETYDTIRAEAKNLETHVPSSAAESSLENQSTQEESNSPEVAHLRSVNSDDSTHTGGASNGIQDCDSQLKTVYACLALIGLGTCAMIGLIVYICVLRSKLSSRNFSRAQNVKHRNYQRLEYVA
The following text describes a protein:
Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MAGKEGDYYKKGETKEGGFLKFLYNPDTKEVFGRTGLSWFKITVFYIIFYACLTAFWTIMLIVFYQTLDTIKPKWVLDRSTIGTVPGMGFRPNPPEQTVDSTLIYFKSGSQGTWKYWVDDINEYLKDYQRQEGDGEHLRNCDFTQQRDPNENKACRFAIENINNNCSASNNFGYEYGQPCILLKLNRIFDWVPEPFENNSFPSKLPKYIQDSYDPRYVYITCEGENVADEENMGPLAYYPSNGIENYYFPYRNTPGYVSPFIFVQFWHAERGVLINMECKAWAKNIHHDRQDRVGSVHFELMID
The following text describes a protein:
Function:
Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system.
Miscellaneous:
MISCELLANEOUS: Isolate N1 belongs to genotype A.
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface.
Sequence:
MLIIFLFFYFCYGFNEPLNVVSHLNHDWFLFGDSRSDCNHINNLKIKNFDYLDIHPSLCNNGKISSSAGDSIFKSFHFTRFYNYTGEGDQIIFYEGVNFNPYHRFKCFPNGSNDVWLLNKVRFYRALYSNMAFFRYLTFVDIPYNVSLSKFNSCKSDILSLNNPIFINYSKEVYFTLLGCSLYLVPLCLFKSNFSQYYYNIDTGSVYGFSNVVYPDLDCIYISLKPGSYKVSTTAPFLSLPTKALCFDKSKQFVPVQVVDSRWNNERASDISLSVACQLPYCYFRNSSANYVGKYDINHGDSGFISILSGLLYNVSCISYYGVFLYDNFTSIWPYYSFGRCPTSSIIKHPICVYDFLPIILQGILLCLALLFVVFLLFLLYNDKSH
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.
Sequence:
MSVINQKIPVGILGATGTVGQRFIQLLESHPRMVVAGVGASERSVGKMYKECVNWKLDTPIPEAAGTLIIQPCDPTFFVKSNCRIIFSGLDAAVAGDIELAFLKAELAVFSNAKNHRMNPAVPIIVPLVNSSHFDMIPHQRSLFSLNRGFLITNANCSTTGLVVALKPLQDAFGPLSRVVVTTMQAISGAGYPGVPSLDILGNVVPFISGEEEKMEEEASKILGTVSKTDFSFVTAQDMRLSASCNRVAVIDGHTESVFVEFKQRPAPTIEQIETVLSQYVSEPQRLGVYSAPEKAVVVTHLPDRPQPRLDARIGKGNAVVIGRIRPCNIFDVKFTLLSHNTILGAAGSSIMNAEIAIARGMISD
The following text describes a protein:
Function:
May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.
Sequence:
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLFRSEQMEFYNLVIPRESAWDVMNTLGYFDSVHIIDYDPTLPQINRPFSNYVKRCDDVMQKIEQIDGEMRNFKIEKRYSPDVIDLLKKRNGTHKQFEELEQDICKVADDLEHQQQTMNSLQEKKNTIRENLEVLRNAVAFQNEDSEEASLLGFQKMVGVILKEDEMRFKRIIFRITKGNIHVDIMDIQEHFIQQDRRIVQKCVFMLIYPNGDLTQKKIQRVIESFSCNKFDIPTSSDQHAQRITMLENQLNEADQLLHLTITQINKRLQDLAEVKYNCSWIEEMRILVTKEKYLYMNLNMLNMTNSVFHGQIWLPQGQDQKIQQALRNLHGNDKQLPSGQIQECQTQLTPPTYYKLNSFTYPFQEIVNTYGIPRYKEINPGLSTIITFPFLVGVMFGDIGHGLLLFVCGLYLTTEDARKSIFSGIVPMRYMILLIGFFACYNGLIYNDFLSIGLNLFGSCYNLVDGEYELQEDCVYKFGIDPAWGSSANQLTFMNSFKMKLAVIIGVTHMTFGIILKGFNTLHFKSYMDFFCEFIPQFLLLLCSFGYMDFLLFLKWSTKFEDTKDAPSVITTMIDMVLRPFDVPEKPLFESGEQQRFIQLLLLTIITFCIPVMLITKPLLFSLKKKNPHQYQQIPSYVPDEDPNPEQLQNDMQKEQSQPHSKVSVQQHNEHDDIGELIVHQSIETIEFVLGSVSNTASYLRLWALSLAHSQLAEVFFSMTIASHIGDGGFFGTLGSIVQFPGFALATFGVLMCMDLMECFLHALRLQWVEFQSKFYKADGYLFKAYSFTNIKSNEQDD
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Subcellular Localization:
Cytoplasm.
Sequence:
MLFSRLILDEVENIVSVRNISKTSQAYQDATELNPVSYLFASYQRLAAEKPTSPPQLLPTLHKCHQLIVRTLVTSILTPEIFEESNIVECLKDVVFQLKSEGTDIQRLFDPMFRKIVRLITQEEVSEIPLLCVKYLLIKTIALCFIHNLTLQVYLQLILFCVYAPYNRSLASIYMVQGRNKLPKSGRSLLYIYLRKSSLVTDPNKPTHPFFNEISTLQQSGVEREEERLQMCMDKFHSHLHVLFRNILRHPSCRTKLLSWINDLMTQHAFCAKLWTHERADPSKSMFTTDGIFINLSSVLVRLSLPFCADSSENAKSSNKFLKIDPTYCAATGCEDRVERDVHLGGLHKETCFLSLPEVDPPTLQLSGTYNFISECFFAAHRSFCLGLHGLLVKLYKLNQMLSKMREVYLDSLASGIEGESEVKQVFEKALANLLSTKATIYNPTFVNNCTRFFATTAQFLTQVALTEDRTKLCEFKLPLSETPPTPLYYIPEFLVQNLIDFLIYLNRENPEQMEDSQKFIPTFISLIAVYMGNKSRMQNPHLRATFSQALEGLLPLETEQSTATVERRKQSFSEFEHSKYLTTCVIHLFIDVEFTDDRDRFEEKFNNRRPLYPILRFLWNDERGEGKEAIRELAIEAVSNIESAKPPLLLTFVNLFLNDSIYFMDEAMNYMGKIKIEEQERDEGEWEQLPPEEKKEKGKILEQYVATARFYNVMSAETIEALSYLSKMEEVQELLCHSLLVDRIANMLNHILLHLVGSRQNMLKVKDFSHCAFKPALLVEGVCRIYSQLQHGDTFCIAVAQDGRSYQPDLFPRAFRVLRKINSLELSLKIHNLSLRIAELGNKEQTEEELFQDAPDEFFDPIMGTLMRDPVILPSSKKTVDRSTIARHLLSDPTDPYNRSPLTMEQLEPDLQLKQKIEDWEKNK
The following text describes a protein:
Function:
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MPHLFYGTAQNGEVIFDEREAHHMRVVRLKEGDVIEATDGNGFSYTCILKSLKKKTAAAKIVKVEEKEKEPTEKLSVVVPIGRWERTRFLIEKCVELGVDEIFFHKFERSQHEISLDKAKIVVREAAKQCKRYLFPKVSFLEKLEFSGNVITLDLDASQNLLDANLEGSITVVVGPEGGFSEKERELLRSSTTIVSLGKKILRFETAAILTVGYIALKKQKI
The following text describes a protein:
Function:
May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
Subcellular Localization:
Cytoplasm.
Sequence:
MERYKALEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINQQQNAESQGKVPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIPERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVVHKEKQVRKKEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRLNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVELSELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSARAQASSPTLSHLDNATEALPTDPGPGPTPDEPCIKCPENLGEQQLESLEPEEPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRLRVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEMDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVDTTHLENVSPRPKAVTPAPAPDCTPVNSATTLKNRPLSVMVTGKGTVLQKAKEWEKKGAS
The following text describes a protein:
Function:
May be involved in transcriptional repression. Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density.
Subcellular Localization:
Nucleus.
Sequence:
MENQRSSPLSFPSVPQEETLRQAPAGLPRETLFQSRVLPPKEIPSLSPTIPRQGSLPQTSSAPKQETSGRMPHVLQKGPSLLCSAASEQETSLQGPLASQEGTQYPPPAAAEQEVSLLSHSPHHQEAPVHSPEAPEKDPLTLSPTVPETDMDPLLQSPVSQKDTPFQISSAVQKEQPLPTAEITRLAVWAAVQAVERKLEAQAMRLLTLEGRTGTNEKKIADCEKTAVEFANHLESKWVVLGTLLQEYGLLQRRLENMENLLKNRNFWILRLPPGSNGEVPKVPVTFDDVAVHFSEQEWGNLSEWQKELYKNVMRGNYESLVSMDYAISKPDLMSQMERGERPTMQEQEDSEEGETPTDPSAAHDGIVIKIEVQTNDEGSESLETPEPLMGQVEEHGFQDSELGDPCGEQPDLDMQEPENTLEESTEGSSEFSELKQMLVQQRNCTEGIVIKTEEQDEEEEEEEEDELPQHLQSLGQLSGRYEASMYQTPLPGEMSPEGEESPPPLQLGNPAVKRLAPSVHGERHLSENRGASSQQQRNRRGERPFTCMECGKSFRLKINLIIHQRNHIKEGPYECAECEISFRHKQQLTLHQRIHRVRGGCVSPERGPTFNPKHALKPRPKSPSSGSGGGGPKPYKCPECDSSFSHKSSLTKHQITHTGERPYTCPECKKSFRLHISLVIHQRVHAGKHEVSFICSLCGKSFSRPSHLLRHQRTHTGERPFKCPECEKSFSEKSKLTNHCRVHSRERPHACPECGKSFIRKHHLLEHRRIHTGERPYHCAECGKRFTQKHHLLEHQRAHTGERPYPCTHCAKCFRYKQSLKYHLRTHTGE
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGREKGGSSRNKSRPSSSSFAAAQVRAAPVGFGGYVGSSLVDSTFSGERETSQDLDGEAALHLKRLSKRDPTTKLKALVALRAIFKEHSVDELSAILPSWVFEYKRLVQDNNRQVRENVHGAMADLTTNAGKGLLPHLRSLMGAWWVSQFDPSREIAEAAQRSFQVTFPDRKKRVDALIYCFKGIMTHLDENLKLTPQALIELGTLPEEVPEKLERILSCSLLALAALLDVLVGSTSSLWKEGAVESISAASAAAGTGEPVKEAATSLFFKHKFFQSFVKNKSSQVRLASYQTLLTYLQHIPEVFTDEENLDNFVKLVLGALGEKVTSCHQSMWDMILLFSKNIPQAWGCSSIRKAVLPKFWEFLRHGCFGSQQISYPYILPFLALLSPQFLAPPQDFFLEFFGSLWQGVYVPALSIADRLSLFKTFQECFVWVVKNSKRYAEATSDKLLQDFLVKEVLLKIVWCQYADLSCQIFAESSQDQDFASAVVKFPTSKSVLPRQICDEVAATIISILIPLSQEGVLHAFWSGFQSSCVGVLLDTSSGNESRLARLGTFFSVLDVKIPNKEESSNTWVLLDVVQPFVGKGFSAIKSSGHPEALRLFGKLISSYGTFAFAMKEQILGDSIRRRFLQEVVPWCLSGDENRPIEPKIELLLSFFEVKEFHSYWKPTIDCVTAWLRPGDKQSELNENDLFQVEVLATLVEKFSDRWVRLVKPGGNASEDGSDPHAFEPWRLPKLDIVGLVVASSNNLIHPSCVRLLRNFLSPVIPKQSLLSPDAIVQLLEKLSTYLLEVLDLHDMPWTRAAPSLILSGKANYNVNKAHSGDVEKVNIFDLAMSALEVVEVTLPSLGAMQLVPTGPQLLSTMFCLYWAFLKPLLRETSEDKLEGSDDERGEEDAYPSVDGGEENTLNQDLTSTQNQIERSRYSFLKCLQNVRRICSPTIYQKLGTECRGCVRRILTEIVRSSLVSEEPSDVVLTSSLCASWVREIVEYFCIGEDEIQATISCTLAPNLFWPNWVAVPPPNDNSFPLVKPSQKTTLIEEEVHQRFCAYTDTLAKYLSPSRVYAGCDSMTSNEVYRVWLVIELLCSWEWPGGSASSHLLEFLCDISRHSTVEKIPLLLDICFRSLLAGSSFTSSGPIDHEGPVESDLIPDIGSPTRALLTLLRALLNGEAAWRRGIAEKFFFEYVAKSSNVTDSADADALKVLPFVLSILMPVMRDSDLGVFDVENFQSLKRIVCDWLNKALSFPPLVDFEKGSTELIGKHWLEVAVACFPLQMPGVSSGIAAAASAKVSLQETSLLLRLLRRQFLVARDAEAKLLSSDTTDVMLELVPELTLAKLVAASVAYCWQDFSVEEWALIMKCLRKWVDSAVIEYEEMTEVVVNFHKGGQEGDLSLQQLSERKILIELATTALSILILLKDINKLETVTALRALGTLRLSNWVAVEDHMMESVLRILLATGLSEAAALEFNAGGDAANTISKHRMAESSLWESLATVALGASSRAREAAARAADLWGVGKGSISALYALLLSPNSSGALQWVAFQFLSTVPIQHLAVTWGGISQNQGEVGEGAEQEAAKGEAALTTAATLRPELVKLLETPARLLLQSSFTSDLRLHYLLGWSLLLMRLHSLSPLSPTRERLLNFVRDSDLSPTLLDCLFQHIALDLTSGTSTSRRRTAPAGAKVSIAATSATRAVSSGTVSFAVENLWPVKEESLVILAGAIYGLLIRVLPACVRIWFTGLRDRSTASAIENFTSSNCSTQLLADEFLQLQASVVPDDTLSIRANRTLREVIAVYKKEEACLDIVIRLPSCYPLRAVEVDCTRRLGISETLLRKWILSMAAFLRNQNGAMLEAIQMWKKNVDREFEGVEECAICYSIIHTTNHSLPRLACKTCKHKFHSACLYKWFSTSHKSTCPLCQTPF