lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Sequence:
MIRAFFPLKKMRRNYRYFLLGAILLVGAVAVYNEFIASSVWRSDSNSGIEDSTWQRPILDQTDEGKMQLASVEDSDVWSSRFNPQTWKPEFIGQANLHVFEDWCGSSIADLHKNMHYPLYPHSRTTVKKLAVSPQWTNYGLRIFGYLHPFTDGDFVFALSSDDNSEFWLSTDDSPLKLRLLAWVGKTGREWTAPGEFDKYASQTSRPVWLSSHRRYFFEVIHKQNDRGTDHVEVAWQLLNQDFSFTVIESNHISLYVDESAFLMSDVSHIPQTAASHQLAPTKQHSAEADMLREDPRDELYRVNLMNSEYLEGVLPDCSYKPSYIIKDFPLMRYQGLQFVHLSYVFPNDYTRLTHMEMENSCFYSESPEYMRMYGFSRYMNIDHPFGQRQDDMDFANLVSNEEEENLHNYIDETEKKSNLKKTKDNALYPDYGDNYDNSVLKQRRHLLSFDNQEQNSTKGKPSVARLHTQGLQDTQGNHATPQLPLLLSKVALKHQQQNKTEIKQNSSLKKDKKKHLKVHQEKKQKVNFQRKIDPQIKNDKKPAKSEGLTTSPLEQLPLKQNLSLISSEKNRSKIQKIKGTQAQNTAGQTLVTKRADQKKLVTRKREVLPANTKHFTAFRDDAVNSDRVESNPGNHIRAKEIELNMLVNGEEMKNFHKNVKSSQRRTYKKSTKTAREEGLERTEDNPYKSTEIKTQANKEERQPAWWEENHYNADYDNSETPAPVFDVQVNWNQTFKVNPLNLQRLRTDWIDLQCNVSGNLVLQPSDALPIVKAFIDSLNDKHYGQFTLERVVNVIKRVDMPQGSRYLLELVLKDAKGQRLRLSHYIYGLKKYSKKNSWDFGFHASQSKTILCNPVGFRWNPSATVHFIVPVKNQARWVRQLIDDMEQLFRETGDFNFNLIITDYSSTDMDVRNALEKSSLPRYQYVKLSGNFERSAGLQTGIDLIKDDNSIVFLCDLHIHFPPSIIDTIRKHCIKGHMAFAPIVLRLDCGTTASEAKGYWEVNGFGLLGIYKSDLDSIGGMNTMEFKDRWGGEDWELLDRCVFCVSPHERNFFFFFVVFRISLETGFS
The following text describes a protein:
Function:
Essential in controlling the S-M checkpoint that couples mitosis to the completion of DNA replication. It is also required for the response to DNA damage (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MKFKAKISKASILLKTVQNIMKIYNECICHITPDKLRFIIQSDFNDGMQVFCEIQRSLIFENFTIESLSDNEIQFQLDLESLRRVLQSATSNGVSDIFTNLTKVRGGPVLHFIIKSGTSGTVIFQDIPIVLLTAQQMAQINEPTLPDPLVHILLPNLKNLQKVIDKMKNISDCLKIMIAMNNRLSFEVETSSGSISTFYSGLDHPQFGDHVLSPDLQATVCVDIKKFAKVLHIHQLKPSEVVLCLYERSIIVHVVLTDIMITYYLPVLIKN
The following text describes a protein:
Function:
Specific inhibitor of cysteine proteinases. Probably involved in the regulation of endogenous processes and in defense against pests and pathogens (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MESKTFWIVTLLLCGTIQLAICRSEEKSTEKTMMLGGVHDLRGNQNSGEIESLARFAIQEHNKQQNKILEFKKIVKAREQVVAGTMYHLTLEAKEGDQTKNFEAKVWVKPWMNFKQLQEFKESSS
The following text describes a protein:
Function:
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.
Subcellular Localization:
Mitochondrion. Nucleus.
Sequence:
MRQPTYPLGTVLAYGSCGKERIALDSRPAHKGKLCRYPHRQCLRKPITGYSYCVRHILRDKNSPYVQCSYVGKVGKNSGKQCFFAALKNPQHKSQLCKFHHQQQQRKQTKKLPCKGKKKKIAIGEMILNHLQSCYDPTTSTNANNKSNKKRNKNPTPLTPSNKRNDSQSQFSDDEIVINNDNEASSTFAKLPVEDVWRGDADSEAESDGMDEDFQLLKNANVYTEKEACKIYCQKLSKLKELYNDQLDWMQSLLRKKRKQYLASVKGVEDLTGVKSEGETIRSYATAAYRRYQTKFGKEALLLKHTKEKDGKVTSYKGLTQRCIYNKNGVKCSRRCLPLTKYCSRHICFDSEQVLFRKCSFIGSNQHSCSYSVSLISDISTCPLHTQPKIEDKGNQSVDGDVTSTNNTLGNNINTVHSISNVNNDNEQDEIVVDDI
The following text describes a protein:
Function:
Required for assembly of a normal spore coat. May be a component of the innermost layer of the spore coat that aids in its adherence to the prespore.
Sequence:
MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYVSIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKVSHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEELSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESVASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAEPAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYALRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNADLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIEVRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYLTKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILYIPQYKNSHA
The following text describes a protein:
Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
AKYIALVLAFLEMALSFYMLSGLDFAATIDSQNLQYQINTPESSFLKTSLHLGVDGLSMLFILLTTILTSLIILSSFSQTVKYKNTFYGLILLMQFGLIGVFTSLDGLMFYAFWEVTLIPIWFICGLWGQEDQKLRFTTKFFVYTFIGSLFMLGGLIYVYNHSASFALLDMYNSDLNVTQQTIVFWFIFVAFAVKLPVFPFHTWQPDTYTYSPTEGTMLLSGIMLKMAIFGVLRYLLPIAPGAIMGISGQIVLTLAIIGIVYGALIAIVKNDIKRIITYSSLSHIGLIVAGIFASAILTLNGRFTTEGAEGAVIQAFAHGINIVGLFYCADILYRRFKTRDIRQMGGLAKVAPKFAVLFLIIVFGSMAVPLTNGFIGEFILLKSISDYNTTAVIISGLTVILCAVYMLRMYGKAMFGKGDEVLLANMKDVSGVEFSVLASLVVFVILFGIFPNSILEM
The following text describes a protein:
Function:
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Preferentially uses NADPH over NADH as cofactor. Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4 and may promote neutrophil recruitment at the inflammatory site. Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MVRAKSWTLKKHFVGYPTPSNFELKTVELPPLKNGEVLLEALFLTVDPYMRIAARKLKEGDMMMGEQVARVIESKNAAFPTGTIVVALLGWTTHSISDGKNLERLLAEWPDTLPLSLTLGTVGMPGLTAYFGLLDICGLKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAAGSDEKVACLKKYGFDVAFNYKTIESLEETLKKASPEGYDCYFDNVGGEFSNAVTSQMKKFGRIAICGAISTYNRTGPPPPGPPPEVVIYNELCFQGFIVTRWQGEVRQKALRDLLKWVSEGKIQYHEHITEGFENMPAAFMGMLKGENLGKAIVKA
The following text describes a protein:
Function:
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. Is essential for phosphatidylserine (PS) biosynthesis and PE seems to be the most plausible substrate. Plays an important role in microspore maturation.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Note=Mainly localized in nuclei and ER membranes during pollen development.
Sequence:
MEPNGYRKERRKEQHLGRMNGGGGDVETDLDPWTAWAYKPRTISLLLIGACFLIWASGALDPDSTTSDDLVTSVKRGVWAMIAVFLAYSLLQAPSTVLIRPHPAIWRLVHGMAVIYLVALTFLLFQRRDDARQFMKFLHPDLGIELPEKSYGADCRIYVPDHPTNRFKNLYDTVFDEFFLAHIFGWWGKAILIRNQPLLWVLSIGFELLEVTFRHMLPNFNECWWDSIVLDILICNWFGIWAGMYTVRYFDGKTYEWVGISRQPNIIGKVKRTLGQFTPAHWDKDEWHPLQGPWRFIQVLTLCIIFLTVELNTFFLKFSLWIPPRNPVILYRLILWWLIAIPTTREYNSYLQDRKPVKKVGAFCWLSLGICIVELLICIKFGSGLYPTEMPLWVVTLWGSVGLGLVAFLLSWTWKIQKILAQKRR
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MLGFKWAVVVILASLEKLIKSRFARKTLGAPGLQGNTKQEQRQEFQHRPAIFGFPVVNQGRLCNRAIAVAARALDKMSSLAKQLKQLQIPAQLASPATQTQKQKDSLLFTGREAADIDNETVFSIARNGLDELELIEAGFKNYEETLFNEVFKKTERSIQSKEFNERLNLQIAKFLKLLSPYFLLKPAQKCLEWLIRRYRVHIVNVDELVACALPYHETNLFVRVVQLLKIRDSSSKWHWLLPLQKSGSPLARTTLLNRCISDLSFLAQICEMVTSGVESGCPISCLRVLFSFYASTLVGVLEIVDKVSEGIITRLLPNIIEGLKSRISEYRAASYMIVAQLCLKCTLDRKLLKSLMEHLCKHLGPELVNEGLLCLTAMCQTQDLIELSRRSFKSLTRTPNLPQHLHGLTSSHNMTALLQIVIPQLVSGVVAESLDVDNAQKCPLMDILICLLKDLQLESHIVKTASRKLLEQYCEERSKHNDKSSIKRLNNKLKALPQILEKRYPSELEKAIEEYLEDLKATGEGSEDEKYPKWTLELMSLALSGLQSQINPDSRTTLTLSLHHPNTDIRAKAVDHLYQMLKEHKGVSQDKDFLRGALLSRLEDDEPSVASAVLDIGKTLLDCVPTSDLVEKLFQLVSKTGKEWKEVSKKAVSILCGPYLTADNATLLDTVVFGQISLFFSHPKSHQSPVDLALTISKSDVAKRHLLLTDLKTLIKEKDWKAAKDSSDHDAHAVANRALASWLGDQLVKLTQKQQLEMVTKLIDYSKSHPADFAFKVTLGNSLGRLVFKATLTDNDLSLCETILSFVKECLKGVMELKPSQQKFHLDIHLSDDGMVPKILLSEYMSLMRRNKSKKMANIRASMNLWVLGNLIRNMPVFKTTAKGAWWNIEEESSSELMYSKILLSVFEMLAPASGTTLPIAHQDIFRQLLQVFIQHHLPDKLTLLHFLANVWSSKTVASPATLQVQSLHIGAVCLKVMGSSDVTHILEKTDTVVVSLLVPLSSMVAPIRKAAVECVRGLYSTAEKNLSGPVGVLIALLAENAEEIQADHAQIKRLFGSTLSLPESKSPKGKSKKKAEQKTALLEYVVRHAVSANTPVHVQIALLIVLTEVVSQEMVHLCLPRVQDLMKKAQEKRSLNSDESICLQHLTKKFTYVAAPLLESDPLCLQLLEGLFSLGVTLCPGHPAPAMSILDQLDDKFFQVIPAGVVQQKVLGMLLDLHLSSTDVQLTAKTKDVLNVIVLKAEQVIEELSQLKAQPKTPKPKKQKRSATQEETSAKELKSWQRITTILELLQHKSNITDREHMVPVLFALLARCVEREIPEEAIPDYITQLVLAEILNICLILLSNKTPDAVPESQFNVELVVQCIRVSENPQTHHQALLLLSTAAKLYPEKVLHNVMSIFTFMGANLLRQDDSYSFQIISKTVDTVIPALIQAGEKQKLLKLQSKGTPPATLNDIVVMVIRVFVDASPHMPEHRRLPVFTHLISTVGAERHLHAAVALLLESYIVHPAQPDDEGVKHSPLDIDFCISLCQEFDPSVQAEGMLKLVKYLAQLPMEKPEGHHYHPRRRKSAPLFSGPTPLFDVHVHSAKHFRQFKFTVLGLVPTVLGNDNFIAKIAEFEGSTSRQMDGIYLGLIEELLKLVTTTAQYSEQQTQETAKKFWRALLHKAYDIIDKVNQLLPTSVFIGVIQRLLVNDNVTVRRKAMELLNAKLAHYTIQPNQVNELLDLVNDLVAFVEGRCSGEETAVNRQTALYSLKLLARLLAEQEPAIFTKVLELSIKIFTAKDENILVASNALLCLAEVCSGLKANAISYLPQFMPNLIKMLQPSKEQKSALLLCCVVTLHKVISTLPHFMSPFLVDILVQVCLQSVRASEETEDEDVPNQSTMQAQVLDRLAAVRKDLANAITSRVLLPAVSQCYYTLLDTQQQPAVTPLLDILSGSITAMSTKDVMSHHDQLFKVFLVLLDFRVTQHQCGQGLVEKIEGGVIDSLLSLVMKMSEATFRPVFLKLVEWATRGNAHKRRLLVFYRLCVSIAEKLKGLMTLFAGYILKNCASLLDANNSSKTDQLFFEEEGVEDQRGSSVQLVKFILDCLQKCLLYSTKGFIDKERFDCLMQPIVDQLENQSDKDKFQQLVTGHVVPCLAQLAVASGSDVYWKPLNYQVLLKTRHTSSQVRFAALKALEELHRQLGEEFIVLLLPESIPFLAELMEDECFEVEQQCQHVVSEIESVIGEPLQKYFEP
The following text describes a protein:
Function:
May play a role in neurotransmitter secretion.
Subcellular Localization:
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
Sequence:
MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGKKTSWRENREAVAPEPRQLISLEDEHKDSSAYKTEEGTSVLSSVDKGSVHDTCSGPIDELLDGKPEEACLGPTAGTPEPESGDKDDLLLLNEIFSTSCLDEGEFSREWAAVFGDDQLKEPAPMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MCPGGRYAGLDLPAAAGAGNLRPAFDVLDADHDGRISRDDLKTFYANAGATDERFDDDDIEAMIAAADADLDGFVQYHEFEGLLGRAAKAGADSGCRSAMEDAFRLMDRDGDGKVGFEDLKAYLGWAGMPVADDEIRAMISMAADGDGGVGLEALARILAVDFDAIV
The following text describes a protein:
Function:
Catalyzes the transfer of the terminal amino group of L-lysine to alpha-ketoglutarate to yield L-glutamate and 2-aminoadipate 6-semialdehyde ((S)-2-amino-6-oxohexanoate), which is spontaneously converted to the dehydrated form 1-piperideine 6-carboxylate. Probably plays a role in persistence (Probable).
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target. Various compounds targeting the LAT enzyme have been identified as potential anti-tuberculosis agents.
Domain:
Contains a Glu-243 'switch' that allows the enzyme to change substrate preferences in the two half-reactions. The unique substrate L-lysine is recognized specifically when Glu-243 maintains a salt bridge with Arg-422. On the other hand, the binding of the common C5 substrates L-glutamate and alpha-ketoglutarate is enabled when Glu-243 switches away and unshields Arg-422.
Sequence:
MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT
The following text describes a protein:
Function:
Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.
Sequence:
MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQLVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRELWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.
Subcellular Localization:
Cytoplasm.
Domain:
The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain; In contrast to classical PTS systems, the fructose-specific PTS has no requirement for HPr; FruB combines a IIA domain with two HPr domains.
Sequence:
MLELSESNIHLNANAIDKQQAIEMAVSALVQAGNVENGYLQGMLARELQTSTFLGNGIAIPHGTLDTRLMVKKTGVQVFQFPQGIEWGEGNIAYVVIGIAARSDEHLSLLRQLTHVLSDEDTAAKLAKITDVAEFCAILMGETIDPFEIPAANISLDVNTQSLLTLVAINAGQLQVQSAVENRFISEVINNAALPLGKGLWVTDSVVGNVKNALAFSRAKTIFSHNGKAVKGVITVSAVGDQINPTLVRLLDDDVQTTLLNGNSTEILTALLGSSSDVETQSVEGAVVGTFTIRNEHGLHARPSANLVNEVKKFTSKITMQNLTRESEVVSAKSLMKIVALGVTQGHRLRFVAEGEDAKQAIESLGKAIANGLGENVSAVPPSEPDTIEIMGDQIHTPAVTEDDNLPANAIEAVFVIKNEQGLHARPSAILVNEVKKYNASVAVQNLDRNSQLVSAKSLMKIVALGVVKGTRLRFVATGEEAQQAIDGIGAVIESGLGE
The following text describes a protein:
Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MMDVPSSWDALRKQARKLEAQLDEQMNSYRKAVSTKVPAKNDTSENNLESGIDRLLKQLQQVNSQMQAWVSSGGTEMVSHTLTRHQEILQDLTQEFYRLRSSLRAKKEHASLLEDFREFDRTRLDLEEGVGSGEQALLKEHASISRNTGQVDTVISQAQATLGALVIQRSTFGGINSKLSNVSSRLPTVNSILSAIKRKKSMDTIILSLVASVCTFLIFIYWLSK
The following text describes a protein:
Function:
Choline/H+ antiporter, mainly in mitochodria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Note=Mainly expressed in mitochondria.
Sequence:
MSSEDLQDHHEIGNEVIKKKGVYTKKKCQDCFFLILFLLFWAGMIVVAAFGVKNGKPDRIVKGTDQYGNICGVNNIEQGILNETQARDTTNEPYVYFIYYPDLIGINYRVICIEECPNSTYTDLNDPNQLICDYGTVPATNQISPNGTCMGKIKSKLIFNRCIPDVTNTSVVLNSIVDEIYQFVNNQLTSDLSVEILTDLTNSWRYLIYGALIAMGLGLTWIFLLRFFAGFITWLTVFAAYACLGLLTAQVYFQWQDSKDAYENTIPSQRLVMQEKNILALKVIFIILCVVCGIFALILLALFSRIRIAIRIIKECSRAIGIMPSIFFFPIFIFLLLCGFTVYWVYIGVYLATAGSPTYDDQYRFTGYEADSKLQKIQIYHFFGYLWTFAFILALNQTTIAGAISSWYWVQDKKDTPFFPVWSSFFRVIRYHLGSIALGSLILAIVQFIRWVLRFLEKKFKGKEAYLARFIVRCLNCIFGCFERFIKFLDKNAYIMVSIYGYSFCQGAKRGFQLVLTNILRVAAVNLVSSFLMFLGRVFITAATVGISLYLLKEHENLSFYIIPVILIGFIAFAISTGFMSVYDMSIDTMLLCFCEDCERNDGSPERPYYMSKSLRKFVDGKGRSKCC
The following text describes a protein:
Function:
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures.
Domain:
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence:
MNSFRESDEEDNNPFSGTNHLYASGIGAVPEGDDDFLSAEVDTADETVQETREQMMSRLFGECEGPRESSAGGWTSGSMGSIGAPDGHSDEVTEFGIDTVLVEGEVRTPGRARVPASYPDAEGSLGALRIVDAGQYKDTFGNYAIGYTIAYEGRQVTRRYSEFDSLRQALARLLPTVIIPPIPSKHPLIRYFLNPLNAENDIRIIEKRRRLLSRFLNNCHDITDIREHTVFQKFLNPEYIWSEVLLTPPVSILPTNNLLAPPLNPTKPSPLHLLLPTPPRRTTSYGSPKTNNPEYDIRFTELESLLLRYHKCLQPVLASSRQKKIHFKQLASSLADLGAYYNAFSLEDNVINLPHQMDQIRDLSRAIEKIGQAVDVNYVSSELLVENIMILLEEPIGEMLQFVQEGREVLRFRMQKQQQFHIIDTTIKKRRGRIEELRNFQAQLARLEAALKQNAEESPTIARAVQRLDAQHLHKQRKSPSGELQWTGLFKSRSGSVRTHDSLTTRPVTGDVDVDLLSDEERAREIARLEGDLEKLNECYKLIQRDMLQVNESMARSFDWFIMYLHDTWALVLRNYTRTLLNWLKDCLTAWKNARVTIDTIAV
The following text describes a protein:
Function:
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Subcellular Localization:
Endomembrane system.
Sequence:
MSDGQYGPISAGIIRSITDKSYERRKAAALDVEKLVRDLFNNNQLSQLDKCLSVLGELINSGNSNQRKGGLIGMAAASIALGNKNAPPYTAKLVEPIIPCFHDADLQIRYYACESLYNIAKICKTSVLAHFEDIFDVLWRVTADSDQNVRGGAELLNRLITEIVLSEQEFDIAILMSLIRDRIYTQTSSNRRFILEWLNTIDSAPFFSFCNYISEISDGLFKMLGEQAPAVRDLCETVLGNFLTAIRSKPESLSLEDRIQMINVLVVHTHENEPFLARKLSLIWLEEFVKLYKTDLLVMLSTCLVGILPSIVETELKADAVNRLLMALVGEAKLEQDILDKTIEVLLKYIKYDVVETRVTVLNWIRHLHSSMPGQLFVHMHQIFPVLLNTLSDTSDEVLLLDLFLISNICQSESAPDQVDVSTFGLNETELKQVSHISPFLIKFVLSLLEMFRTEPTLLRERGVLIIRQLCLLLEPAHIYRVICVLLERESKHNFAQEMVSTLHGVLLTATELFILRDELRALSNESSRSLFECIFRVWSNRPIALLGLCLLSQHYQQAADIALLLSQVDITVDVLLEIDKLVNLVESPVLAYVRMDLLSSIHRPPLCTVLSALLMLLPQSEAFVTLHKRLQAVPALVSIDNSPYAPKVPPCRIDFPPLMLHFKAALARRQTEVRSRHRDLLSGVVTQMKNVKI
The following text describes a protein:
Function:
Reduces benzil stereospecifically to (S)-benzoin.
Subcellular Localization:
Cytoplasm.
Sequence:
MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLTQHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHYQLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRTFGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDFIAGTLLSLLEKGTENGRIYDIKEFL
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MPSLALGSEKTEKRRSTRISQMVVPVVKKTNTRSSRSLHLKGAPQRQEVSDSSASSSSGSSDEDEYQPTENDVQDEADDHMDYKEFSPEIDEDFSDSPPVRSLRSRTNSDSSDKENGRRRTRSTKRAANETPSKILAEKLSKTSLTTPKKNSARDLRSSKTPTKRKDETPRENMQKSRGRPRKVFLESDGDLSEEEDVSNKRENQTPRERLTMKIPKNMIKPRITPVVISKTPGGTLRTRRRMRQNSEELDDVVDPLDSNSAKTLKELASRLHLSKVPEQLPCREAEAREIESFIREVIDRKRGESSAMYISGVPGTGKTATVRAVVNAMKKNAKCPKFVYVEVNAMIFKKTVFVEIHNGIQEEFNISKKSQTRAKISASTARQELNDIFKKQDSKRPPIVILIDELDSLCNRKQDVLYDIFEWTALPQSKVTIIGIANTLDFPERMLCQRNASRLDKRRLVFQPYRHEQIQEIVRARLQGSNLVEKKAVELVAKKIAMNTGDLRQALDFLCRSIGVAVEKKAEKLEVVHVLEAQKAVLESLKYRLVKGLRLHQLTLFRAVENLTRENEEVIFAEIYKNYCIICSKLSGIEPASDNFAYGMLLELATTSLVTLARGDQGTMNRRVKLGMTTMEAERAIKEATEKHKSIYSV
The following text describes a protein:
Function:
Calcium-dependent cell-adhesion protein.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MESLLLPVLLLLAVLWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDSRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQMELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYSVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNAGIGYLVTIVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLTITCLLGCFIKGQNSKCLHCISVSPISEEQDKKTEEKVSLRGKRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVSSVIREAGNGCEAISPVTSPLHLKSPLPTKPSVSYTIALAPPARDLEQYVSNVNNGPARPSEAEPRGADSEKVMHEVNPILKEGRHKESPGVKRLKDIVL
The following text describes a protein:
Function:
Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival.
Subcellular Localization:
Endoplasmic reticulum. Golgi apparatus, cis-Golgi network.
Sequence:
MADDALFDFLFMEMTNSLYSQNDPAERDASVTKLEQIGFSTGYRLVEKLTKDWPRFKTELDVIKFICKEFWSAVYKKQIDNLRTNHHGVYVLHDNRFRFLTQLSNNKQYIEMAPKYLAFTCGLIRGTLANLGINSVVTVEVTVMPACKSPARTFSKYKLTVV
The following text describes a protein:
Function:
May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (TcpA) (By similarity).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MIKKIISVFLLLACIITLAFTAFFYHSKLSDQTKSISSLSSQQAQERLQSYQDSLDFYKKLNTSLSVAIANSLRDKAVEELNAIALRIQENHGFIGVTFASLDGTMFTDIGTLDWNAKTLRRDWFVKTVELGTKHYTAFDIDKTTGQHVLTIATPVYVGNDIVGSVALDIAGDQIASPNGSGMFMMTDRNFNVFASDLTHSTLIGKDLTKEKPLFKNLVSGQYVTFSDADSHWFAVSQTEIDGENKLFTIIDIQQIVQTYKRDIQLIIAGFSGFSCVMLIGLYWVLSKELSGVRQIREWILALSDGQIKERRPIKFHNELDTIAQSLENLQFRLLDVVRNSHRTMNDLSIKQTDITYSIEGNTNNSQQELGLIEQVATATTQLSCTSFDVMQQAQSAELNAETAQKLIAESHDIIDSSSKQTEMVTLSIHESQQIINQLREFSDNISSVTDVINNISDQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLAVKTQQSTIDIQGIILKLQEQSQLADQVMTRNVSLIHETQVANRALIASFNLISDKVLEISNINSIVSTAANEQKIVTEDVAKQMEDIRYLVQENLSAMERTKQANQNISDLTTNLNDALSFFKIELTS