lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) (By similarity). The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro).
Sequence:
MVTMENSDEIMQILERFTDLKQKEIPKELEEYLQYVAKTGDTIFKWSSLKYLFREKLLSVIKHFNEDSPRLEEIPNYPNVDPFNYETMKSSLLERLDLFNAAPFTVQRLCELLIDPRKQYSRIDKFMRALEKNILVVSTIDPGRKRTESENGDSLDSVVNGDLSMEVNIDIEMENNNGNADEGSSPGAGSAGCAQKASCPRSDDNDQPKAKKAKLEIDGEERSEASDETDTEVATRVKNEKDEKNDNDETDSPHEAAEIEEPDEEVDEADQETKTTKQPAYGSQKEGEQEESFPSSADDEAEDPMVSKSIEAEKELVAQEKKREEDKKVAIEPKEEIVKKEEVVESDKPDGKVAQLGDKAVVKKSTPPADGENQEPVKVKAENEKEEKKHAPIKTEKQDDIDSTETDDAPSAEKPAEEKIASSESKPKTKSEDDPEAETKKSQPEKTETEAAEKSVSDEKQAAEPNAESENRNDLTTSKATEAAQESVEKSPVEDASSPAVEDLAAATTPQSPLGAADSAAETPPAETGDDSQASPLVAAVTPPVLALNDQPMEDTPAEEEARVSPSATVEEVVMAESANAGAMATEEAAKDDPAAMEIDDTSQEVMMQ
The following text describes a protein:
Function:
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
Subcellular Localization:
Endoplasmic reticulum.
Sequence:
MATTQSAFIFALCILMITELILAAESYYDILGVPKNASDRQIKKAFHKLAMKYHPDKNKSPGAEAKFREIAEAYETLSDENKRREYDQFGHAEGRRSNGNTFQQPFNFNFDDLFKDFDLFGQNHNTRSKKHFENHFRSHQHAHSRQRRSFPEFSFGTGLFDDMFEDMEKMFSFNGFDTHQQTMRTGSKFHGSSKHCRTVTQRQGNMVTTFTDCSGQ
The following text describes a protein:
Function:
Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization.
Subcellular Localization:
Cytoplasm, cell cortex. Cell tip. Note=Found at the cell cortex and the growing tips of interphase cells. Localized to the septum region during cell division and upon cell division begins to localize to the new end, with some remaining at the older end.
Sequence:
MASKMPEGSPPTSRSIQSRNSSYSTSSNERIGTPSTISLSENSDLSKLQSTNDFESREDLSLTSDDNNDPEYVMCYNTVYHQKTKINDKLLSETEQLRKIYPLESRVFPKPTIVKEITNERTKRYTFYDDDAPLTNQHTVLDEATYNRILKRIDFFIEKVVEVPPTYHFLSLLNVQLRIQPIWWMDEFAERNGIESLLSALRNLGHYPERASKTPLESQIIQSLFHCLNSENCRRRYQSSAKCSVPGFNALGTIAETVLSKSLNSARMATFLLKFLCNKKGLSYFKAVIRAFEWLVEQKLSKTRFSAWMHSFNDVITGVRVCADSSPQAIVHMDEFEDTDCLIDYLVATLALIRDLCAAPPDLQLRCALRHELLSAGLQKAIDSLLKWRNRHVRDALQLLIKEHNADARRFRSGSDVNNVDRKCVKKQMNYREESHTPHGNTTRKTSTPVSNNRPTTPEQQAVWDVFQRIYTRFTGSEGSKESFIKLLEYFVTEPDNGKIQKSMQLLTHTLEALEGFKTAKADTNVGLTILSQRLLDKLGTAEEIAEYKTKYNGAMLENKHLKEQVESMLSQLNVGPRDPMQFLKKQLDELKAELNLRDNLLASMQREFETRYRAQIQAYNKLQSQMEHVQNSNEQHLQPGLLNKVSKSFDSVHRRNLSQDSLDAMTEQFSYHVEPNILSGSGIPVRVHTPSKTEDLDESFSGSEISSSPSPLLPDVSDTVEEQQKLLLKSPPPPPPAVIVPTPAPAPIPVPPPAPIMGGPPPPPPPPGVAGAGPPPPPPPPPAVSAGGSRYYAPAPQAEPEPKIDETSLTEEQKIQLEEARKQRKAADDAARAAIEKYTSIPSLRDLHKPTRPLKRVHWQRVDPLPGPNVFTKFCLNFDITAKVFIDNGLLDFLDEKFDNTPREDFVAVEISDQRSSLLPDTVEQNMAIILRSVSNMPVEDLVQKFLVEPDFLPASILYFDRASLASTNAYTDPFIPYSTDYTKKNPKEPTADVNSLSYFEKFFVLFVVNLRHYFQERMKALKFRSTLFGDLEILEVRMKEVIDTSDSIMEDKNFAEFFQVLLIIGNYFNEPYDRASAFSLYMIYRLETLRDSSSALTLMHYFDEIIRTRFPELLQAESTFKKIQSVSGYNIDAMVAGVDGAYDEFCDFQTSLKDGALSKCDQHHPDDKAYDILSEWLPEAKERIRNIKKLKTDMLTKLENTVKYLCEYDSIDKVRNSFFKNLNSFYEMYSIAKAENEERFEKEKRRIMSEDRDKLIRGRQKTSIVAKYRNKRELPEDSDDKQDTASKDKNSLETIDEKMEDASKIEGDAKTGDDNEMEDLDKMEDLEKPDYAEEKDPYITVMSELRSRIQNVPKRTVTVYSDEGVATLEPGAQGDDVVDKAKMILEKMEGHSQLLTSSANPDEEVLRAKLKAAERLQKPAIPRTRRKGHTEPKSAKSLLAELTNGSNASNLVENDRQKQ
The following text describes a protein:
Function:
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Sequence:
MPKEKYDPPDPRRIYTIMSAEEVANGKKSRWDELEISGRVRSLSMSLWSLTHLTVLHLSDNNLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNVVSLRELLLNNNLLRVLPFELGRLFRLQTLGLKGNPLSQDILGLYQEPDGMRKLLNYMLDNLSVHPEQLPQRPWITLKERDQILPSVPFTVMCFNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVSCDADIISLQEVETEQYYTLFMPALKERGYDGFFSPKSRAKIMSDQEKKHVDGCAIFFRTEKFSLVQKHTVEFNQIAMANSEGSEAMLNRVMTKDNIGVSVLLEVHTDFSGAGMKPHHSSEKQLLMVANAHMHWDPEYSDVKLIQTMMFVSELKSIIEKAASRPGSPTPDSNSIPFVLCADLNSLPDSGVVEYLTNGGVADNHKDFKELRYNECLTNFSCNGKNGTPDGRITHGFQLRSAYENNLMPYTNYTFDFKGVIDYIFYSKTHIDVLGVLGPLDPQWMMDNNIAGCPHPHIPSDHFSLLTQLELHPPFLPVINGVHLPSRR
The following text describes a protein:
Function:
May be involved in protein sorting and cell wall formation.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MNSIINAASKVLRLQDDVKKATIILGDILILQPINHEVEPDVENLVQHELTKIIQGYPIQDNMIINSKKGTVEDDLCELNNYTCFALSKSFDLCHDSRNFNIAQPKRWIQLLETLTDSVSFAVIVQIILTLSNISLINKQTLGKLKKLRIRIFEILSNKNDSWKSTLLQKNLIEWYIFMLSVDCTPLELQNLYLHKELKFCNGILNSLTLQVSDPRSQNYLQFENTYKLFQIQKSSRINNSFLFYIEFNSVTSNRIMTIERHIYLEIKEGQFCISNDNYIIGLFENFEFEAGTLYFIGVLIDHNNRITLYVDGSMINQLTLFENSICQLSTCELGSMICSIKVYRFYLWDGLLTEFAINILQAIGTNYQYTFSKKKEGPEVLSLCQDFLIAKAHLMARPTTEISSTKYIDEIELLEMENIIIDVNPNDILQDFTESSNFTVKFEESTNSKNIPEVGKCYFYRSSNLVSKFVSIDSIRLAFLNMTESGSIDDLFHHVSHLMNLLRNIDILNWFKKDFGFPLFAYTLKQKITQDLSQPLNIQFFNLFLEFCGWDFNDISKSIILDTDAYENIVLNLDLWYMNEDQSSLASGGLEIIRFLFFQISSLMEASIYSKFNSNKFNDMNILEKLCLSYQAVTKRENQNSKFNELSSDLISVFVTLLKSNTDKRHLQWFLHLSYYFIKRKDVRSTEIILQAVDQLFSFYLDQGSDENAKILSEIIPLKLILMIMDQIVENNESNPITCLNILFKVVLTNKPLFKQFYKNDGLKLILTMLCKVGKSYREEIISLLLTYSIGNYTTANEIFSGAEDMIGGISNDKITAKEIIYLAVNFIEWHVINSNASDSSSVLDLNNHILRFVEDLKSLSAVPINESVFDPKKSYVMVSLLDLSIALNESEDISKFKSSSKVISELIKGNIMCALTKYAAYDFEVYMSTFFCHSTEYKLVYPKTVMNNSSYLELSFIVTLLPEILNDLVDSNNNLNLMMLKHPYTMSNLLYFLRKFRPDTSQIVMPKDFYFSSYTCLLHCVIQIDKSSFYHFKNVSKSQLLQDFKICIMNLIYSNTLKQIIWEKEEYEMFSESLMAHQEVLFAHGACDNETVGLLLIFFANRLRDCGYNKAVFNCMKVIIKNKERKLKEVACFFDPANKSEVLEGLSNILSCNNSETMNLITEQYPFFFNNTQQVRFINIVTNILFKNNNFSPISVRQIKNQVYEWKNARSEYVTQNNKKCLILFRKDNTSLDFKIKKSISRYTYNLKTDREENAVFYRNNLNLLIFHLKHTLEIQSNPNSSCKWSSDFAEDFDGMKRRLLPAWEPKYEPLINEEDANQDTITGGNRQRRESGSILSYEFIEHMETLESEPVGDLNENRKILRLLKDNDSIATIWNCSLIIGLEIKEGILIHGSNYLYFVSDYYFSLEDKKILKLSEVSQESRDMTVSLINGPDVKRVSTFLKHEVFVWKLLDITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDVLRVLNKIPKHLPADPIFSSVLQEINDRGNSIVARNGIGKASIASKFTSVFSANNSLIDGFEISKKWVRGEISNFYYLLSINILAGRSFNDLTQYPVFPWVIADYESNVLDLENPKTYRDLSKPMGAQSEKRKLQFIERYEALASLENADSAPFHYGTHYSSAMIVSSYLIRLKPFVESFLLLQGGSFGPADRLFSSLERAWSSASSENTTDVRELTPEFFFLPEFLINVNSYDFGTDQSGKKVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEWIDLIFGYKQKGDIAVKSVNVFNRLSYPGAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPEKIACNVQQLTTEVWRKVPMKPIFEKTIFNLNEKNRSVDYVIHDPSYFDSLYWRGFAFPNLFFRTEESLVSLRIVHKNWLKIGLDIFKKTHMAQITSFAYWKLGEFITGDKNGLIKVWKYRKDKHSVSGNLENKKTMFGHLCELKEMRCYHDYNTLLTLDISGLVYVWDMINFELVRQITNDAQKVAISQHAGSIMVLTKNNAISIFNLNGQIYTSKKFEPAKIVSSIDFFDFTKLDAGYRKHIYWKEMEILLVGFEDGTIEIYELFLNFHNEWAIKLLKQLCTEKGKAITSIKGQGKTYLSQKRRKDTAEPHEIEVIAGTLDGRLAIWY
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Sequence:
MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG
The following text describes a protein:
Function:
Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
METEAADESGFTSVASKRGRRKRRAAGAEPMEAAESAEAAGPQPSKRPAFPPLPAAALGVGKGEVRKVPVPANRYTPLKENWMKIFTPIVEHLQLQIRFNLKTRNVEIKTCSETKDLSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEVTDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADSKIHILGSFQNIKMARTAICNLILGSPPSKVYGNIRAVASRAAERF
The following text describes a protein:
Function:
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKATTAPGRKPRGRPKKLEKEEEEGISQESSEEEQ
The following text describes a protein:
Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments.
Subcellular Localization:
Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. At metaphase, detected at the kinetochores and kinetochore microtubules, and in late anaphase and telophase accumulates at the spindle envelope midzone.
Sequence:
MSASANLANVYAELMRRCGESYTITYGAPPTYLVSMVGAAEAGKKIVLVFKEDRNGAVARLRTTPTRAAPKKEGSADLDLTGSPLKDDCLVDAIADLSIDLQLDHSNPWKLEEEYQRGIPVDKARSIVCSEFLQLAEGLGSVWFLCDGSDLGQTQLLQYEFNPTHFSRGILSYQGVRPAYLVTSQALVRHHGKTPDETLIENSYQVNPHMRLRCSWTSSAALPLLVNLNDCDVALNHTFRVGDCGPLTQDFMNQLRILVYIREDIVSYHTDVKQGVSRDPTYRCGSGIDMDELRESINQTMTDVSGLIGRYSISNAEFDIEDVVQRAKVRQLTDLTDKLWELLKCCHSYKDLKIAFSMLFQCAARCNIVNTPTNKNRLAKIITELANRRLAMPCLSGAEPLELLLEIGLEKLYKDYEFIYTESKMCSTNLLKDDSSGASMDDGSPQNLPQLRKSLHNAVRGDPTPGAGMRKTLLHHHGAVNSRSTKYAGSDDDAGFKNSHFDEHESTERISKLFQIHCTLEHLLMMHIHLNLANVYNDVCSELLKKPPKLVESIDDQLSDVMDIRLSAHYVRDHLDGKDPYSRHITMRSHNKFRELKTTFYFNSENICPPNLAQCFQCDDKEMVKERTYHSWIYHKIRSLK
The following text describes a protein:
Function:
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center.
Miscellaneous:
MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Peroxisome. Note=Peroxisomal localization is dependent on PEX5.
Sequence:
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR
The following text describes a protein:
Function:
Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance.
Miscellaneous:
MISCELLANEOUS: Present with 6960 molecules/cell in log phase SD medium.
Sequence:
MNTVSPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLTNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSMLEREDSQKHTSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLK
The following text describes a protein:
Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
The following text describes a protein:
Function:
Forms pores that allow passive diffusion of small molecules across the outer membrane.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MKKTLAALIVGAFAASAANAAVVYNNEGTNVELGGRLSIIAEQSNSTVDNQKQQHGALRNQGSRFHIKATHNFGDGFYAQGYLETRFVTKASENGSDNFGDITSKYAYVTLGNKAFGEVKLGRAKTIADGITSAEDKEYGVLNNSDYIPTSGNTVGYTFKGIDGLVLGANYLLAQKREGAKNTNKQPNDKAGEVRIGEINNGIQVGAKYDANDIVAKIAYGRTNYKYNEADEHTQQLNGVLATLGYRFSDLGLLVSLDSGYAKTKNYKTKHEKRYFVSPGFQYELMEDTNVYGNFKYERTSVDQGEKTREQAVLFGVDHKLHKQLLTYIEGAYARTKTTNGGVKTEKEKSVGVGLRVYF
The following text describes a protein:
Function:
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.
Domain:
The N-terminal domain is sufficient to bind to viral RNAs and promote their degradation. The second and fourth zinc fingers are involved in binding to specific viral RNAs. Contains a divergent PARP homology ADP-ribosyltransferase domain which lacks the structural requirements for NAD[+] binding. It is therefore inactive.
Sequence:
MADPGVCCFITKILCAHGGRMTLEELLGEIRLPEAQLYELLETAGPDRFVLLETGGQAGITRSVVATTRARVCRRKYCQRPCDSLHLCKLNLLGRCHYAQSQRNLCKYSHDVLSEQNFQILKNHELSGLNQEELACLLVQSDPFFLPEICKSYKGEGRKQTCGQPQPCERLHICEHFTRGNCSYLNCLRSHNLMDRKVLTIMREHGLSPDVVQNIQDICNNKHARRNPPGTRAAHPHRRGGAHRDRSKSRDRFLHNSLEFLSPVVSPLGSGPPSPDVTSCKDSLEDVSVDVTQKFKYLGTHDRAQLSPVSSKAAGVQGPSQMRASQEFSEDGNLDDIFSRNRSDSSSSRASAAKVAQRNEAVAMKMGMEVKGKKEAPDIDRVPFLNSYIDGVTMEKASVSGIPGKKFTANDLENLLLLNDTWKNVAKPQDLQTTGRITDSGQDKAFLQNKYGGNPVWASASTHNAPNGSSQIMDETPNVSKSSTSGFAIKPAIAGGKEAVYSGVQSPRSQVLAVPGEATTPVQSNRLPQSPLSSSSHRAAASGSPGKNSTHTSVSPAIESSRMTSDPDEYLLRYILNPLFRMDNHGPKEICQDHLYKGCQQSHCDRSHFHLPYRWQMFVYTTWRDFQDMESIEQAYCDPHVELILIENHQINFQKMTCDSYPIRRLSTPSYEEKPLSAVFATKWIWYWKNEFNEYIQYGNESPGHTSSDINSAYLESFFQSCPRGVLPFQAGSQKYELSFQGMIQTNIASKTQRHVVRRPVFVSSNDVEQKRRGPE
The following text describes a protein:
Function:
G-protein coupled receptor for the nlp-40 neuropeptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Plays a role in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. Specifically, acts in GABAergic neurons, such as AVL and DVB, to control the expulsion step of defecation. Required for fatty acid uptake and metabolism by intestinal cells and therefore regulates the levels of triglycerides in the intestine.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell projection, cilium.
Sequence:
MNSTDIIANVTKPFVENLTLGETAFYISCGIVGTVFNALVLWIALTYINTEDKPRQIIVINMTVADLLMCIVYMKTRPWLSHFNLWLCHPYYVIIWTCQMCSCLNLVWLNVDKLIYIQFPLHYYQIVNRKRLLWITAATWGGLYAMNIALVTFLKITRGSCLGVSLNPYVYLLSPIFYVVMILTSFSLSALIYCIAHNLTHMEERQRSKLFRRLFFLFSSTLWTFFTCLPYRLLYLFSIFCGETCQINNYYKTATNLFFRLLIVGIMINPVITIWTQRIYRLRLMRMFGRLRENSSTEVLMVSNRRASERPPEHTPLRCDM
The following text describes a protein:
Function:
Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.
Subcellular Localization:
Cytoplasm. Mitochondrion. Note=Lower abundance in mitochondrion than in cytoplasm.
Sequence:
MVTLLPIEGQEIHFFEILESECVLYTGWIERASGSSIYPEAKARLPLEALLGSNKEPMLPKETVLSLKRYNLGSSAMKRNVPGHVLQRPSYLTRIQVTLLCNSSAEAL
The following text describes a protein:
Function:
Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity).
Subcellular Localization:
Nucleus.
Domain:
The PNT domain acts as a transcriptional activator.
Sequence:
MILEGSGVMNLNPSNNLLHQQPTWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDVNGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTDPSIMNTWKEENYLYDTNYGSTVDLLDSKTFCRAQISMTTTGHLPIAESPDTKKEQDHPTKPHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGIFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN
The following text describes a protein:
Function:
May play a role in ribosome biogenesis.
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MADTEAAPAQYKQPSRKGKKAWRKNVDVTQIQSGLEDVRDQIIQGGVIAEKTSDELFAVDTIGSADIQKAVSKRHKPLKVDQILAQRSAVPAVAARKRLSELDNEGKRKKAKISGKEYDRLRQIAYGGEQVNKDVVQTGGDADHDPWAVQEVKKDPKFSFLEEKKAKREPVTLKHAPISQVKSGKTVPAVRKPTGGKSYNPKFEDWQNELMRESDKAVETEKKRLQEAQEEAERMERAAAETESDSGEESVWESEWEGFSEHEDDKLKKKRPERKSLSQRNKIKRRKEAERLARHEAKVKAKEQQVQEIKKLAKSVEAKEKARATVREALENKTLDIASDDDGDEELKRRTIRGQHPIPEAPLEVVLPDELRDSLRLLKPEGNLLKDRFRSMMIRGKVESRRQIPYAKQKKYTESEKWSYKDWELPKARQ
The following text describes a protein:
Function:
Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
Miscellaneous:
MISCELLANEOUS: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).
Sequence:
MVIRRLYQFCASHVVRNCSSLKCAQNIHGHNYEVEVFIETNRLDNANMALDFGLMQQEMQVFIESFDHAHHFWDKESLEFQRFIENHCVRYVKCSFNLSAESYALMFLYYLTKILQKSVFSNDEGELKVSSVRVHETKNGYAESFLKDLENPHFKSLVHDHCVSFSQGIQNLWHDKDFFNKIISDEKQCFFHAKPLHQIP
The following text describes a protein:
Function:
May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC.
Subcellular Localization:
Nucleus.
Sequence:
MSLQFSIDNILGGKMSHSNTTQESAPISPISTSTSMTPYMRAWLSAAAAASYPSSSLAACYSSYLYPYVTSPPSLYNAASAPLLTPYAFAAASSGAQAPMIHPAMLGAAAAPPPPGFFYRLPAKRKRRHRTIFTEDQLEALENMFQKTHYPDVVMREQLAEKVELKEERVEVWFKNRRAKWRKQKRERELMKAETGSSGSAASDHPPSSPERAQSVSPCPRYGVSGGSSCDEMEFGVGAGVLPRIVVPGQNLSVSVE
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MAGKTRKSEASTSSSSGDNNNNRGETVVSDCGRRRSSCGYCKSTSSTSVSHGLWAHSITVDDYQDLLDRGWRRSGSFLYKPEMEKTCCPSYTIRLRASDFVPSKEQQRVSKRIQRFVDGTLEVKKSVEATKDPSISASACSEASSSGTKESLSNKNKEKNVGDHITNYLSEQVDNVIRTCSESGQFPCSVQLPKASVKKVSQAKRKLLVEGAEDLMYSSNIAFQIAATIRQARSIAKDASRSAEDNPLSPKIIAEKLAASLDQLANTNGLAIRACNGHINFYTATTQVSSNEDSHIALGAQESATERKDFSLRKSSVHPQGKRLRLEIRLKRSSFDPEEFALYRRYQINVHNDTLDLVSESSYRRFLVDTPLVPVQPTGDSRVPLCGFGSFHQQYVIDGRLVAVGVIDILPKCLSSKYLFWDPDFAFLSLGKYSALQEIGWVKENEVHCPSLQYYYLGYYIHSCSKMRYKAAYCPSELLCPLRYQWVPFDIAQPLLDRKPYVVLSDFVLLQNGESSQPLVPENVMEVQGDENHNEDSNDVLIDGDDDEEDDDDDEFESDDDDSGPDSFGQTSVEIENGNVSDILIGLKGSRLRYKDLQRAIGPGERLESQLRRYKRVVGEKLAERMVYSLG
The following text describes a protein:
Function:
Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
Subcellular Localization:
Nucleus. Note=Nuclear localization depends on pafo-1, leo-1 and ctr-9.
Sequence:
MDPLEALQKHVQRPEEFPLREVTVSGISYVAFGDYAYKKDTETSLQIYGKSDEFYSLESLVVFLKYSHENHGVYVKEAAAAGVRAVTRIDRKNVTEYLQGDRTDFPALMNQVNPLSLRQLLHSSEPEAKKPRLDGEAAGEPMDTSTSDEPQESAVSAAKKEVEIRALNDNLTKDRIAEMRRKRQSHREKGIVTIDESLSTLTSASLPKTRIHKTRENVMLGARDLSNVLDIITSAQRQWDLNEKKEKVAAVHATNLSKDQSGAAGGQQQRSGYSRYAQEAFAHEKTKEIQTEGSFIGSNFSSIKQGHHAVQKAPDAPPGRPPLAKPIQLLTSSTATSSGSSAAQNGSKRTSRSPIIIVPSAMNTMINLYNVRDILQNFSYVPVDQRRKETNKKPVDLAIQRQKNGVTYNIRVIDNAEKLANDDWDRVIAVFVMGVAWQFKGWKWNGNPTDIFTHIPAFHFHVDQDKPVAQVMQWNVHKIPVSATKRHMDKARFSQVWETIENFVRKNKPHLTARLGL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MRKFTPKFVPRRKNGPVEEKDVDERVKIEFDVESQKKWKASRPKPEIKLTASGPFALGPNASSSGTGRPIGSVYVPPPNVKNEEKDDALSKLAASSGHDEGHDEDMVDILKLRELNGQEQGKTDIGGKDLLVPIITDRMLPESNDEKLKHHAESAIHTTVINKEDEEQERVALDLQSLAQHLGLTEQEGMEDHFKDQMVLMQFPDKLPRFMGDADVDPVWPSSEVKEEEAGEKTDVEEKKDPDKHGRENGNIDDLTSLPYPAFHPPAGQIGVLRVHQSGKTTLEMGGVNFVVQSGSDCLFLQEIAVVDYDSKRIWNLGSFERRMIVSPDF
The following text describes a protein:
Function:
Binds preferentially double-stranded DNA. Modulates general plant growth and stress tolerance. Confers sensitivity to salt and genotoxic (methyl methanesulfonate, MMS) stresses.
Subcellular Localization:
Nucleus. Note=Displays a highly dynamic speckle distribution pattern in interphase chromatin but does not associate with mitotic chromosomes.
Sequence:
MKTAKGKDKVKTTKEALKPVDDRKVGKRKAPAEKPTKRETRKEKKAKKDPNKPKRAPSAFFVFLEDFRVTFKKENPNVKAVSAVGKAGGQKWKSMSQAEKAPYEEKAAKRKAEYEKQMDAYNKNLEEGSDESEKSRSEINDEDEASGEEELLEKEAAGDDEEEEEEEDDDDDDDEEED
The following text describes a protein:
Function:
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Sequence:
MSEKGETLIEDTAEIEFEQTVDKTQQWGRLKNAAAFSLFRDLHMNESLQRKHARSDYKVYDLNNRVIFHVINTTAMPITKDGPFCLKVMNKDKKSVAKFLRNEPKRSYKQTGLASLFGCCSDTEDTMEVLDDNGLIIATSFLHHDQFRGILITMKDPAGKVLIGIQASRDQKDVFAVSGPDNRYLGEIRQKIISSGNSTDNYKGVACWFSTEVSLNVKVFFMAAAFLIEIDYFSETKSRQAPFRTPEADYLNPIIKTPPHNERVPKMKTNISKTRKKKGKVSDASKDSRPSETKKETLMMPEIHHTKHFDSIGGEEQAFAKKEKVEEFKPTEAVKEEVDVNGMSRDQFRNAAKKVVDYLMKQDESIRAARCSPALKPGYLKALLPPKAPQKAEDIDDILEDYHKLIVPGLSHSSHPNFHSFYPAGNSFHCLLADLLGGHIGDAGFYWTSNPALTELEVLMMDWLGEMMALPKEFLLFPEASRGGGCMQRSDTESNFLVLVAARTDMIRRMKQRDKRLRSSDILARLVAYTSSDARRSIKMKMAAEVAMVKMRVLPTDQNFILRGDTLHAAIMADIERGLIPFFVGANFGTSGPCSFDHLHELGPVCREHGTWLHVDAAYAGTALICPEIRGLMRGIDWADSFCTTPSKLIIAVCDVCCLWVRDRHKLQHASLENHPDLPFKGLPTSQRVGALKIWFMIRSFGVENLQNQIREHIRLGQVMTKILQKDLRFEVCNKVVMGLICFRAKSNDMFNKALLYRCNETGNVSLASCVLQNKFVIRMCINSPKCSEEDLDSAYKLICNEYDILKPFQYRIEVMNQAELETFIRDPAKIHSSAEVSRRFPVVNPLEPCRSLAQISSQMHTAEYADPPGKSNKSPQVAAKGELPSAAPPSSRTPNSDISEKSDR