lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MVRAQETVYDLITKCSVRRVPPKQFVNFYNEFFNERYDSVLENGNPAGESRPTAPVYEEVAQDLVRILNDSRVNLVADYVLEIVLINLNVDLLRLFLPKLHHVRNVMLLVHLFSRATAFISGLDNKLLAEQISDTVYTDVTPAVLSFNMQAIDDQLVIVLAKFLHAVLRLPEGQQKMGSVPTKQKAATLLQRLSTIDRLLYKRFIADLDGKLRLSGAPADMSFPLPPSNMPSPSVTSPKYETSSVGVMKRSTSMSNEAKYQDIKLARYYKNLWLNNKIHYCTVSDPLFLEKYDSILELATGGGLSADRPVKAKIADLVETAFTCFAQFVSNKLYHQSNSNFSLLERKWTVFVTKQLPLIIKSSIPDKTDIVLRTLENIDDKVIKAIKSYNTEKEEVKNRTEDLFDDYPVNSLDIRHEFLKNLIMMGLQPPTVLNEYLREDQMVDLKSLVTSEHLIIDNSQGVRETILNVRNFITKSIESLEFENLFDDGNQLLVTNDHGIIQIAHNLETISPTKQLEIANILYDLLSAAIESLDHKTISKVLTILTLNVGHLLTNIFCLTGYEKFARAVIRFIDVIWESNKSKSNDMVSDDSEFENINSAMAYTLSLCFIIHVVDIYGVNVEALVENPSKSTVLRFLSKLGEIPEVFVAPEGDLESSKTLLQQWLRELFVKNLISDNLMKSADVKVMGFMIPFIFKQTLLNVEYGIISDISSFVNGFEYFLQPFLSVGLINIVFWLEKYLLALKTTESFPKINGALFDILGAIIAPKSIGSDAKAIHSVVLKLKCVGLLKELKSFQVPSESNYGIYSSQTRQDPRLEALISKLELIAQSSALYDVDPRIISAVNNNYSQKHISYNKVVLTSDIPINKIMTNQINSFWNLHSSTYYNFDYLLELIDLVTPFKFVQDVFQTLKYKVTAYGVPGSATKPSSAALDQVLGYVFYFMVLRDIKCPEEKSLLLEYLDSGRFPSSISATVLTSDPTTISGMPPVSMPYDVKSEQDAMEGVDEDFDMLFGESFSGLPDDVQKSADMKPDTGIKEDDSEKSSYVSAARLTESFGVIFSKMKKDKLEAYQAGQISEERYQCFMGLYDKYVQTLRHSVI
The following text describes a protein:
Function:
[Polyprotein pp62]: Essential for the correct assembly and maturation of the core of the virion; [p35]: Component of the core shell. Binds to phosphatidylserine, which may enable the core shell binding with the inner membrane; [p15]: Component of the core shell. Binds to phosphatidylserine and DNA, which may link the core shell to the inner membrane and to the viral nucleoid; [p8]: Component of the core shell.
Subcellular Localization:
[Polyprotein pp62]: Host cytoplasm, host perinuclear region. Note=Found in perinuclear cytoplasmic viral factories during assembly; [p35]: Virion. Note=Located in the core shell, which functions like a matrix between the DNA and the inner envelope; [p15]: Virion. Note=Located in the core shell, which functions like a matrix between the DNA and the inner envelope; [p8]: Virion. Note=Located in the core shell, which functions like a matrix between the DNA and the inner envelope.
Sequence:
MPSNMKQFCKISVWLQQHDPDLLEIINNLCMLGNLSAAKYKHGVTFIYPKQAKIRDEIKKHAYSNDPSQAIKTLESLILPFYIPTPAEFTGEIGSYTGVKLEVEKTEANKVILKNGEAVLVPAADFKPFPDRRLAVWIMESGSMPLEGPPYKRKKEGGGNDPPVPKHISPYTPRTRIAIEVEKAFDDCMRQNWCSVNNPYLAKSVSLLSFLSLNHPTEFIKVLPLIDFDPLVTFYLLLEPYKTHGDDFLIPETILFGPTGWNGTDLYQSAMLEFKKFFTQITRQTFMDIADSATKEVDVPICYSDPETVHSYTNHVRTEILHHNAVNKVTTPNLVVQAYNELEQTNTIRHYGPIFPESTINALRFWKKLWQDEQRFVIHGLHRTLMDQPTYETSEFAEIVRNLRFSRPGNNYINELNITSPAMYGDKHTTGDIAPNDRFAMLVAFINSTDFLYTAIPEEKVGGNETQTSSLTDLVPTRLHSFLNHNLSKLKILNRAQQTVRNILSNDCLNQLKHYVKHTGKNEILKLLQE
The following text describes a protein:
Function:
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MASDMVFEFWQQLCQEHGISQDGNLEEFATEGGDRKDVFFYQSDDTRYIPRAILIDLEPRVLNGIQTGPYRNIYNPENFFVGKNGSGAANNWGDGYQTGESVHEEIMEMLDREADGSDSLEGFMMLHSIAGGTGSGLGSFLLERLNDRFPKKIIQTYSVFPDTTNSGDVVVHPYNSLLSMRRLTQNADSVVVLDNGALSRIAADRLHVQEPSFQQTNQLVSTVMSASTTTLRYPGYMHNDLVSIVASLIPTPRCHFLMTAYTPFTGNNVEQAKTVRKTTVLDVMRRLLQPKNRMVSTIPGKKSCYISILNVIQGDVDPTDVHKSLLRIRERRLATFIPWGPASIQVALTKKSPYIPMNHRVSGLMLANHTSIATLFKRIVRQYDGMRKRNAFMEGYKKTAPFSDNLNEFDEAREVVTDLISEYEAAEDADYLSPDAGNAAPAGEASDRRLP
The following text describes a protein:
Function:
[CLE20p]: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular Localization:
[CLE20p]: Secreted, extracellular space.
Sequence:
MKNKNMNPSRPRLLCLIVFLFLVIVLSKASRIHVERRRFSSKPSGENREFLPSQPTFPVVDAGEILPDKRKVKTGSNPLHNKR
The following text describes a protein:
Function:
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Synapse, synaptosome. Note=Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity).
Sequence:
MYLTPSEKRINLSKVHPTDKLADQIFAYYKEGERDGKDEIIKNVPLKRIRK
The following text describes a protein:
Function:
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It can also use NAD to oxidize shikimate.
Sequence:
MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELGFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQICDKIKGIALECGAVNTLVVENDELVGYNTDALGFWLSLGGEGYQSALILGSGGSAKALACELQKQGLKVSVLNRSARGLDFFQRLGCDCFMDPPKSTFDLIINATSASLNNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELETPFQDGKDMLIYQAALSFEKFSASQIPYPKAFEVMRSVF
The following text describes a protein:
Function:
Receptor-like protein kinase required for cell elongation during vegetative growth, mostly in a brassinosteroid-(BR-) independent manner.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MGIEKFETFILISTISILLCICHGFTPVDNYLINCGSPTNGTLMGRIFLSDKLSSKLLTSSKEILASVGGNSGSDIYHTARVFTEVSSYKFSVTRGRHWVRLYFNPFDYQNFKMGSAKFAVSSQSHVLLSDFTVTSSKVVKEYSLNVTTNDLVLTFTPSSGSFAFVNAIEVISIPDTLITGSPRFVGNPAQFPDMSMQGLETIHRVNMGGPLVASNNDTLTRTWVPDSEFLLEKNLAKSMSKFSTVNFVPGYATEDSAPRTVYGSCTEMNSADNPNSIFNVTWEFDVDPGFQYYFRFHFCDIVSLSLNQLYFNLYVDSMVAATDIDLSTLVDNTLAGAYSMDFVTQTPKGSNKVRVSIGPSTVHTDYPNAIVNGLEIMKMNNSKGQLSTGTFVPGSSSSSKSNLGLIVGSAIGSLLAVVFLGSCFVLYKKRKRGQDGHSKTWMPFSINGTSMGSKYSNGTTLTSITTNANYRIPFAAVKDATNNFDESRNIGVGGFGKVYKGELNDGTKVAVKRGNPKSQQGLAEFRTEIEMLSQFRHRHLVSLIGYCDENNEMILIYEYMENGTVKSHLYGSGLPSLTWKQRLEICIGAARGLHYLHTGDSKPVIHRDVKSANILLDENFMAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTDKSDVYSFGVVLFEVLCARPVIDPTLPREMVNLAEWAMKWQKKGQLDQIIDQSLRGNIRPDSLRKFAETGEKCLADYGVDRPSMGDVLWNLEYALQLQEAVIDGEPEDNSTNMIGELPPQINNFSQGDTSVNVPGTAGRFEESSIDDLSGVSMSKVFSQLVKSEGR
The following text describes a protein:
Function:
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
Miscellaneous:
MISCELLANEOUS: Has been reported to be involved in cell division regulation, but it was later shown that this is not the case.
Subcellular Localization:
Cytoplasm.
Domain:
The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.
Sequence:
MHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMATTLAALTLPQMVKLAETNQLVCHFRFDSHQTITQLTQDSRVDDLQQIHTGIMLSTRLLNDVNQPEEALRKKRA
The following text describes a protein:
Function:
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
Sequence:
MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDARLARLDWSREQRLALVSAVAETGVRVPSMCLSAHRRFPLGSEDDAIRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQQANDETRCRFRDGLKESVDMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAENPAAEVAKARDWVKARMASAGLVEAA
The following text describes a protein:
Function:
Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of lanosterol to form eburicol.
Miscellaneous:
MISCELLANEOUS: In Neurospora, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Neurospora, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
Sequence:
MPSTIALEKEDHQRDAEFKKVMHGDSAKAAGGVAALLKKNTEAQQIAVDEYFKHFDNKTAEAETQADREARTKEYATLTRHYYNLATDIYEYGWGQCFHFCRYSPGESFYQAIARHEHYLAAQIGIKKDMKVLDVGCGVGGPAREIAKFTDAHITGLNNNDYQIDRATHYAVRDGLSGQLKFVKGDFMQMSFPDNSFDAVYAIEATVHAPKLEGVYGEIYRVLKPGGTFGVYEWLMTDNYDNDNVEHRDIRLAIEVGNGISNMVTISEGLAAMKNVGFELVHHEDLADRNDPMPWYWPIAGELRYMQSYLDFFTVVRMTHTARRILHGFAGILETVGLAPKGTKKTADALARGADGLVAGAKKKLFTPMYLMVGKKPLN
The following text describes a protein:
Function:
Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Promotes keratinocyte differentiation via activation of TGM1.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPGAGSSSVFSVLSNSAEVKRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQKMKYSIVSRNCEHFVTQLRYGKSRCKQVEKAKVEVGVATALGILVVAGCSFAIRRYQKKATA
The following text describes a protein:
Function:
Plays a role in the regulation of Wnt signaling pathway during early development.
Subcellular Localization:
Nucleus envelope.
Sequence:
MAAPSGTVSDSESSNSSSDAEELERCREAAMPAWGLEQRPHVAGKPRAGAANSQLSTSQPSLRHKVNEHEQDGNELQTTPEFRAHVAKKLGALLDSFITISEAAKEPAKAKVQKVALEDDGFRLFFTSVPGGREKEESPQPRRKRQPSSSSEDSDEEWRRCREAAVSASDILQESAIHSPGTVEKEAKKKRKLKKKAKKVASVDSAVAATTPTSMATVQKQKSGELNGDQVSLGTKKKKKAKKASETSPFPPAKSATAIPAN
The following text describes a protein:
Function:
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Sequence:
MAAQSSSYIPLIIIVAFCWFISNSNGRLLSEKLTWKRLITVDQSGEGNFITVQDAIDSVPSNNVDVTLILIKPGMYKEKVTVPEDKPFIILTGRNAENTTITWDDSGDIYTSPTLSVFASDFTARYLTIQNTYGAGAKAVALRVSSERAEFYACRITSYQDTLLDEGGSHFYSNCYIQGGTDFICGNAASLFQKCHIHSISDGNGAITAQRRMKPEEDTGFYFTDCRVTGIKSCTLGRPWGPYSRVVFVNSYMSNVVNPYGWDDWGKPSTHSSVYYGEHKCYGPGATRSKRVEWSQSLTNQEAATIFTKTTMISAKSWIIKP
The following text describes a protein:
Function:
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding; The box 1 motif is required for JAK interaction and/or activation.
Sequence:
MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTENSSLSSITLLDPGEHYC
The following text describes a protein:
Function:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKKWLVIVLIIAGIRCDGFSDQVFRTLFIGEGNACYRTFNKTHEFGCQANRENENGLIVRIDKQEDFKNLDSCWNSFYPKYSGKYWALLPVNLIRRDTISQLKSSKCLSGIVLYNSGESIHPGDESTAASHDAECPNAASDYYLQDKNEEYCERKINSRGAITRDGLMKIDWRIQMVFIDNSTDLEIIEKCYSMFNKPKEDGSSGYPYCGMSFRLANMAAGNSEICYRRGKNDAKLFQMNIDSGDAPQLCGAMHSDNIFAFPTPIPTSPTNETIITSKYMMVTARMDSFGMIPEISVGEVSVLTSIISVLAAARSMGTQIEKWQKASNTSNRNVFFAFFNGESLDYIGSGAAAYQMENGKFPQMIRSDRTHIHPIRPNELDYILEVQQIGVAKGRKYYVHVDGERYQQNKTQTDRVIDRIERGLRSHAFDLEKPSGSGDRVPPASWHSFAKADAHVQSVLLAPYGKEYEYQRVNSILDKNEWTEDEREKAIQEIEAVSTAILAAAADYVGVETDEVVAKVDKKLITTIFDCLITSNFWFDCDFMQKLDGGRYHKLFNSYGFNQKSTYISMESHTAFPTVLHWLTIFALGSDKETLNVKSEKSCSHLGQFQAFQMYTYTWQPNPYTGNFSCLKSAIVKKVMVSPAVDSQTPEEEMNTRYSTWMESVYIIESVNLYLMEDASFEYTMILIAVISALLSIFAVGRCSETTFIVDEGEPAAEGGEPL
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MALQQLGQETVPLSVLVKRAAEAAYTGLKEVCEAAPEQSDAEKKISLLKFILKTRQRLLRLLVICKWCRQIPLVERCQQLMGTLSNHDMSFTQAADSMFYLHESLQQSRAPMYDVASAMDVLFTGGFPRMPKCIEDLNVQPVLEGWKKDNVLQKLDTLLRSKLLDIAIPKEFTSVSVRDGRLTLRVDGEFEVELTLGYRGNASLWRVLHLKLLVGESSRPAKFSDMQRLALSDDLERRMSALENPFGIIYTVLHEFCAALVMDTLWRQVRALRHGRWKDAIRLDLSFETAASGNPATQAPADAEADPSKSRVHGVKITYWLDLAKGGESLLPSLRIEPGSDQRISCQHQPPLTDPGTGNDAEFVLDQSRLDVEKLILRVINCNIHSRLVEVQKSLKANTYIHRVEDDVDKAYILGVPNGFCVSFPVQDTSDIGEDSLHVRAYGDLYICLSISIRNGRFVLRAPSTLLSLSLVQEMEEAINQGTSVVDVFINLRNQSIIHHYASLGGSMNLKVFEKGAITLKFPEDGPKLGSDVLVLGFPNTGDLYFLAVHLDPAFMPLFVLLEAQKLVPLPNRTTVAAKHLVIRRYMSIDISKFSLAGNDENLSLLSDNVKSGGRSLVPKTAEVRNGFDRMDNQVVKLEKAEQQPNFAMGQLQRYHASPSVSLGSPSSRASFGNHNRKSSSSNNLLALVSQAMGSPARNSFSRMSPSTKLPELEYGRLKSPLLPVDNPASPDLDDDHLSKLIESISTGGPATDNMASTGLRQVHSSPSSRTVKSASKNSLKSLHLVPRKGLPDGLGSPLAKDMDRSPYLLPAPSRQLSSLKRKPESDIFSSLPSLQRLSLGARKKQKVEAPSNALEVFSGQPYAAVVAAANQGKAPPVTHMAVLLHVVKRSWLVIKHARLTNQMDSLGISYVEEGRLSSSAGLIFRLATSRMRGDMGKYCNAWQRISLSLGQHGSDGWEVKVRDSHYKSLWSLQKQKVADWGAGVQLAALSEADAHIKCSQEGLILSYSTVEDDSIKKLLADLERLRSARAFAHCMKKLLEDRMDEGDEGASRTDTKWEAITRAFKVEALGLTSLWFSYTGSMPGILARFVVEWASDQEGCIVHVSPEQLWPHTKYLEDLINGGDVELLLDAIRITAGPLHALAGAIRPARMTAPVSSIVASAISPPGQVSPPNSSATPQSRATGLSIQIPTITSGPGRGPGPGIVPSSLLPTDISVLMRSPYWIRIVYRKQFSVDMRCFEGDQVWLQPAPPPQGAGPDAGGSLPCPQFRPFVMENVLNSSETVVTGVQQNGPASANPRSNASATRNTPSSAASGRNLVIGGPGYPSYRGELNSAFCGVSDDGGYSGAWVPLPALKKVLRSTLKYLGVLWLFAQFPNIIREVLGSVMNGRDGTLLHLDPEQPALRFNIGNCMFAVNMHRHQLYLQGLNVKKFQQPPPELQTDPPGADADLTNGEMLEITEFFAQRVASEPYDASRLASFVTILTLPIAVLREFLGLISWMKEAQKNQAVEATPRPRIELCLENRLVINTTMKEEAGSSTSVKSSILHDREREIVEFALTVFLDLGPHVNVNVAGGAGWLPQCVSVRMRYYYNKGGRRVLLVGLEGSHGGRACWSRGDEWERLKERTKVLEAAAAGQESSGRLRAVAESVQLTLQSALQQLRAV
The following text describes a protein:
Function:
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAWSPAAAAPLLRGIRGLPLHHRMFATQTEGELRVTQILKEKFPRATAIKVTDISGGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIKEMHGLRIFTSVPKR
The following text describes a protein:
Function:
Negatively regulates tyramine beta-hydroxylase tbh and thus the conversion of tyramine (TA) to octopamine (OA). In tyrosine decarboxylase 2 (Tdc2) neurons, acts in an amine-mediated signaling pathway to negatively regulate acute ethanol sensitivity probably via tbh-mediated depletion of TA.
Subcellular Localization:
Nucleus.
Sequence:
MSAATEQQNNGDVAVEKVAADDVSAVKDDLKAKAAAEDKAAAADAAGDAADNGTSKDGEDAADAAAAAPAKESVKGTKRPAEAKSAESKKAKKAAAADGDSDEEEALEEIIEGDSEIESDEYDIPYDGEEDDIECDDDDDDNDDGSGSDDQA
The following text describes a protein:
Function:
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (By similarity). Acts as a regulator of necroptosis (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSAAQGWDRNRRRGGGAAGGASGVSGAGAAGGGRGTGQLNRFVQLSGRPHLPGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQELIERLK
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Subcellular Localization:
Cytoplasm. Nucleus, nucleolus.
Sequence:
MAKQRQTTKSSKRYRYSSFKARIDDLKIEPARNLEKRVHDYVESSHFLASFDQWKEINLSAKFTEFAAEIEHDVQTLPQILYHDKKIFNSLVSFINFHDEFSLQPLLDLLAQFCHDLGPDFLKFYEEAIKTLINLLDAAIEFESSNVFEWGFNCLAYIFKYLSKFLVKKLVLTCDLLIPLLSHSKEYLSRFSAEALSFLVRKCPVSNLREFVRSVFEKLEGDDEQTNLYEGLLILFTESMTSTQETLHSKAKAIMSVLLHEALTKSSPERSVSLLSDIWMNISKYASIESLLPVYEVMYQDFNDSLDATNIDRILKVLTTIVFSESGRKIPDWNKITILIERIMSQSENCASLSQDKVAFLFALFIRNSDVKTLTLFHQKLFNYALTNISDCFLEFFQFALRLSYERVFSFNGLKFLQLFLKKNWQSQGKKIALFFLEVDDKPELQKVREVNFPEEFILSIRDFFVTAEINDSNDLFEIYWRAIIFKYSKLQNTEIIIPLLERIFSTFASPDNFTKDMVGTLLKIYRKEDDASGNNLLKTILDNYENYKESLNFLRGWNKLVSNLHPSESLKGLMSHYPSLLLSLTDNFMLPDGKIRYETLELMKTLMILQGMQVPDLLSSCMVIEEIPLTLQNARDLTIRIKNVGAEFGKTKTDKLVSSFFLKYLFGLLTVRFSPVWTGVFDTLPNVYTKDEALVWKLVLSFIKLPDENQNLDYYQPLLEDGANKVLWDSSVVRLRDTIDTFSHIWSKYSTQNTSIISTTIERRGNTTYPILIRNQALKVMLSIPQVAENHFVDIAPFVYNDFKTYKDEEDMENERVITGSWTEVDRNVFLKTLSKFKNIKNVYSATELHDHLMVLLGSRNTDVQKLALDALLAYKNPTLNKYRDNLKNLLDDTLFKDEITTFLTENGSQSIKAEDEKVVMPYVLRIFFGRAQVPPTSGQKRSRKIAVISVLPNFKKPYINDFLSLASERLDYNYFFGNSHQINSSKATLKTIRRMTGFVNIVNSTLSVLRTNFPLHTNSVLQPLIYSIAMAYYVLDTESTEEVHLRKMASNLRQQGLKCLSSVFEFVGNTFDWSTSMEDIYAVVVKPRISHFSDENLQQPSSLLRLFLYWAHNPSLYQFLYYDEFATATALMDTISNQHVKEAVIGPIIEAADSIIRNPVNDDHYVDLVTLICTSCLKILPSLYVKLSDSNSISTFLNLLVSITEMGFIQDDHVRSRLISSLISILKGKLKKLQENDTQKILKILKLIVFNYNCSWSDIEELYTTISSLFKTFDERNLRVSLTELFIELGRKVPELESISKLVADLNSYSSSRMHEYDFPRILSTFKGLIEDGYKSYSELEWLPLLFTFLHFINNKEELALRTNASHAIMKFIDFINEKPNLNEASKSISMLKDILLPNIRIGLRDSLEEVQSEYVSVLSYMVKNTKYFTDFEDMAILLYNGDEEADFFTNVNHIQLHRRQRAIKRLGEHAHQLKDNSISHYLIPMIEHYVFSDDERYRNIGNETQIAIGGLAQHMSWNQYKALLRRYISMLKTKPNQMKQAVQLIVQLSVPLRETLRIVRDGAESKLTLSKFPSNLDEPSNFIKQELYPTLSKILGTRDDETIIERMPIAEALVNIVLGLTNDDITNFLPSILTNICQVLRSKSEELRDAVRVTLGKISIILGAEYLVFVIKELMATLKRGSQIHVLSYTVHYILKSMHGVLKHSDLDTSSSMIVKIIMENIFGFAGEEKDSENYHTKVKEIKSNKSYDAGEILASNISLTEFGTLLSPVKALLMVRINLRNQNKLSELLRRYLLGLNHNSDSESESILKFCHQLFQESEMSNSPQIPKKKVKDQVDEKEDFFLVNLESKSYTINSNSLLLNSTLQKFALDLLRNVITRHRSFLTVSHLEGFIPFLRDSLLSENEGVVISTLRILITLIRLDFSDESSEIFKNCARKVLNIIKVSPSTSSELCQMGLKFLSAFIRHTDSTLKDTALSYVLGRVLPDLNEPSRQGLAFNFLKALVSKHIMLPELYDIADTTREIMVTNHSKEIRDVSRSVYYQFLMEYDQSKGRLEKQFKFMVDNLQYPTESGRQSVMELINLIITKANPALLSKLSSSFFLALVNVSFNDDAPRCREMASVLISTMLPKLENKDLEIVEKYIAAWLKQVDNASFLNLGLRTYKVYLKSIGFEHTIELDELAIKRIRYILSDTSVGSEHQWDLVYSALNTFSSYMEATESVYKHGFKDIWDGIITCLLYPHSWVRQSAANLVHQLIANKDKLEISLTNLEIQTIATRILHQLGAPSIPENLANVSIKTLVNISILWKEQRTPFIMDVSKQTGEDLKYTTAIDYMVTRIGGIIRSDEHRMDSFMSKKACIQLLALLVQVLDEDEVIAEGEKILLPLYGYLETYYSRAVDEEQEELRTLSNECLKILEDKLQVSDFTKIYTAVKQTVLERRKERRSKRAILAVNAPQISADKKLRKHARSREKRKHEKDENGYYQRRNKRKRA
The following text describes a protein:
Function:
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MAGGYIARVNMKGHYLSWSSDNTYPWQNIQPTQNTKLLGLQDIGFTTDPVRRLRQHNSEIGGGAVRTTRAKGSWDMAAIVYGFPNKVAALRFEWAWQHPLKSRRLRDAVRSDLPASRAAQMQLTAKLHTLAAMLYTVPWSDQPLTLCWLQPDIADKWSNIWQRHCQCQSALPPFLTTRSGNLQDPLFQLNNAAAAASTIQRAALAADHHAWRLAAAAQAQAPDFFTGLGRLDLAAPSVEESGAGPHPSSCSVPPSTGSSAAPTPGALAPQPTKQNKFGVDPRLDSDDRDDNHQFESPDNHEAAAVNVDVVDDSADDGTTDGNEDGPDDVAPHQEVTARHVHGAIGETCGHCHQSVYQELCIVCLNATCTYRAHLLCAAQAAVHPLGQSSPSETRLVPLRHSCPRCAHQAHWASWIAEVTL
The following text describes a protein:
Function:
Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides. In venom, it may participate in the degradation of the extracellular matrix thus allowing a rapid spread of other venom components during the envenomation process.
Subcellular Localization:
Secreted.
Sequence:
MTQNIQMTEMYQIILFASILAAISATSADFKVVWEVPSIMCSKKFKINVTDLLTSHKILVNQEETFNGDKIVIFYESQLGKYPHIESHGDINGGMLQVSDLANHLKIARDNISKFIPDPNFNGVGIIDWEAWRPLWKYNWGRMSEYRDRSKDLVKAKHPDWSPAQIEKVAIEEWENSAKEWMLKTLKLVEDMRPNAAWCYYLFPDCYNYGGKDQPSEYFCKNDIQEANDKLSWLWKQSTALCPSIYMQESHITKYNTSQRAWWIYARLRETIRLSHPNTLIYPYINYILPGTKKTVPSMDFKRVLGQIGSLGLDGAIIWGSSYHVNTEEMCKEMKTYVKDVIAPVASTVIQNVNRCSQQICKGRGNCVWPEEPYTSWKYLIDPKNPTFKHTNISCKCKGGYTGRYCQIAP