lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Cytoplasmic granule membrane. Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MFNPSHSRARRSLKMLWVLVMLLGIRTEALAPGIKAEITLKGLDYGKEVGMEFLNSALLKLSIPDLKGSYSIPLVGPVEWAMTGFQVKALNLGESLIAFVPNSGLKLSMGPAEAEVDGHWSVVASLIRDSGTLSLNVRDVTLAVQVGVHWNGAGRLVVSSEGCSSHIGRLEVTFHGGASWLYNIFFEVLEDLIRKQLNSKLCESIGNAVQTLERTLQTIPESRHISPLADLNCSLVAAPLIMEQSIELDFKGEFYSPASHKEFPVPPAPFSLWKQNDHMLLLGVSDFVANSAAFVYYQAGALSRTFNDSQIPKWFPIRLNTKNFKNFVPELQKRFPNTTMALKIFARLPPRLQSQSGALKVVLPGALQAFVLPKGNSAVPVFLLDMDTEASGQVFASGKNIGASLKLTNFSLTLAHSDVGPFQVDKLEMLMNVALKLVILPKINRKLKNGFPLPTLPKASLQDMVINIEEGFLAIATDVHYGA
The following text describes a protein:
Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
Sequence:
MAIEGGERTCGVHELICIRKVSPEAVGFLSAVGVFIILMLLLFLYINKKFCFENVGGFPDLGSEYSSRKNSQDKIYNSYMDKDEHGSSSESEDEALGKYHEALSRTHNSRLPLADSRQKNYAWETRQKYSPLSAEYDGYSSEASIDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCEFSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSESTSSCQSLEHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEEELNHWTEMKESKGQQVCRWHALLES
The following text describes a protein:
Function:
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Sequence:
MLALGQDEIAKYPFLADAGQYLKDKGFTLEQFGTDPDLKELITKAYERIQVAADGKIYKSDLIGDQVSKEAALPREVFSFLLAIVLLKLSGMHTLIKRFALAEARRAEKYLEKDLADISDESKKQLAIRVIDDLFSVQIEKLDDYFVIPVSDYLKHSINFHEREWKLINRHVENGQVFLTPHETVRLIRKELGTYINSKIVNAKTPTMIPGFEDSVNKLVMLSKKFSTFTVTTGEYPPCIKHAIDILEKGENLPHSGRFMLATFLLSKGQSVQQIAPLFKNAPDYNERVTLYQLNHLAGTSGSGTQYSCPSCEKLKTQSLCFATSECDGIITPLQFGKKRK
The following text describes a protein:
Function:
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
Subcellular Localization:
Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Cell junction, tight junction.
Sequence:
MVFLLGFLFLCGVTDHIGSVSITTPEQTIQEVQGETVHLPCMFTLSPEDQGPLDIEWLRLSGPNNEAMDHVIILYAVDKIYSDFYQDMRGRVNFTSNGITSGEASIKIRDVQPADSGTYLCKVKTAPGVAKTTVQLTVVDYIGSVSITTPEQTIEKDQGETVHLPCMFTFISKDQGPLNIEWLRLSGPNNEAMDHVVILYSADKIHDDVYPDLKGRVYFTSNDIKSGDASINITNVQLSDAGTYQCKVKTYPGTVNRNLQLAVTDHIGSVSITTPEQTIQKARGETVHLPCTFTLSPEDHGPLFIDWMQLTGPQNEVVNRMFIVYLADKIYDNFYQDMKGRVQFTSNDIRSGEASINITDARLSDAGTYQCGVSHAFGTAKGTIQLTVVG
The following text describes a protein:
Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (By similarity). Plays an essential role for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion. Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling (By similarity). Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSAQESCLSLIKYFLFVFNLFFFVLGGLIFCFGTWILIDKTSFVSFVGLSFVPLQTWSKVLAVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKAQMLKANESEEPFVPCSCYNSTATNDSTVFDKLFFSQLSRLGPRAKLRQTADICALPAKAHIYREGCAQSLQKWLHNNIISIVGICLGVGLLELGFMTLSIFLCRNLDHVYDRLARYR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MMNQMGMMMQQQGVGVPGGPGGVGGVGMPGPGGVGVAPGMMQSPQMQQAQQQQVQQQQVQQQQVQQQQVQQQQQQVQQQQQQQQQHSQSAQQQAQQTEKVDNISKVKVLVGPLRDALSTTIKTAAQLIQQNTLADAGSKTVDLNNAPRFDKHLEEFYSICDQIELNLKTTKLCMQQCTSSQQYLPIPVATSQPPLPETNALTYNQYLEVVKLQIGYAKDIHDTLICAAQNISPSE
The following text describes a protein:
Function:
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.
Subcellular Localization:
Cytoplasm.
Sequence:
MRTQSPDYIVIGAGFTGLLYSTLAVLEGRSVFLYEKQNRSGGLVGSIQTPFGLVETAANGILNSYQLEELASALGLNILTTEKKSKKRFIWKNGSPRRFPLSFLDTLRVLYGILGISAEIRAGESVYQWGVRVLGKGAVKNVLEPGLGGIYAGNLKDMSAELALGSWISSKGSLLKNIREIKKIKTKNPKQKKGTVSFRGGLGELLNAMEAKIKSSPNSKIYYSQESPTLSSIRKKYPNSKIILSCGLESSLKLLSSGFPVFKKYEKLCKTLGVVTVTRFGNQPLLGKKSGFGILFPSDSGFRALGVLLNSSIFSGRVSKGHYSETFIFGGALDQEIVKFKEKEIINVLEEDRKKITVQNDEPLNHYVTIWKSALPIYDLALLEFNKELDRSLPEGIFVEGNFRYGIGLSSILERAWNVMRNQKGRT
The following text describes a protein:
Function:
NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it acts downstream of CAMKII (unc-43) to regulate specification of asymmetric odorant receptors in AWC(OFF) neuron via the nsy-1/ASK1 pmk-1/p38 MAP kinase signaling cascade. Required to localize nsy-1 to postsynaptic regions of AWC neuron, suggesting that it may act by assembling a signaling complex that regulate odorant receptor expression. Also plays a central role in resistance to infection to a broad range of bacterial and fungi pathogens, possibly by activating pmk-1, independently of the NF-kappa-B pathway. Required for expression of antimicrobial peptides nlp-29 and nlp-31. Its role in immune response and neuron specification may be mediated by the same nsy-1/ASK1 pmk-1/p38 MAP kinase cascade signaling pathway. Involved in the response to anoxic conditions probably by activating the p38 pathway composed of nsy-1/sek-1/pmk-1. Involved in regulation of the serotonergic response of ADF neurons to pathogenic food. In addition, plays a role in the up-regulation of gcs-1 upon arsenite treatment, most likely through activation of pmk-1, to confer protection against toxicity induced by heavy metals; [Isoform b]: Regulates expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury.
Subcellular Localization:
Cytoplasm.
Domain:
The SAM domains mediate the localization to postsynaptic regions of neurons; The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence:
MLPNRKPPRPSPSFQSLNNNNQRFPLRRSLKIAQAHSLPTVPSEDAKDDDLITPELSTDFDFREIQHRYLMALQNEQDGETTSTDDAFFELDDDDDLSSPSVPGSPVDPPSISVPLPPKSAPPCPTQPAPLTNGDLYPTILSNGTPIPNGRITPALSTVSVSLIHEARLQQSLSTPCNGSEEEMHNGQVRKESEYRRFKSEGSTAGASLPAAEKTHMDELSPVDQRSTSGTARFLIQQDSVVNPSTKMSNTEQVAMMHTLKTKLSKYQAMMDKAFEEIAKVEDANIIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNTAACDQVRMECGKVLEECTSSANLEYIVNKSYTKKIMIVAMKLNKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPECPDILRHAALALANILLYTCFEGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNTKEWLERLLPMLQPSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTFTPTGSQERATSTRRKIQPSASTTSDRN
The following text describes a protein:
Function:
Transcription factor that plays a role in floral organogenesis. Promotes the growth of carpel margins and of pollen tract tissues derived from them.
Subcellular Localization:
Nucleus.
Sequence:
MISQREEREEKKQRVMGDKKLISSSSSSSVYDTRINHHLHHPPSSSDEISQFLRHIFDRSSPLPSYYSPATTTTTASLIGVHGSGDPHADNSRSLVSHHPPSDSVLMSKRVGDFSEVLIGGGSGSAAACFGFSGGGNNNNVQGNSSGTRVSSSSVGASGNETDEYDCESEEGGEAVVDEAPSSKSGPSSRSSSKRCRAAEVHNLSEKRRRSRINEKMKALQSLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTMRNGINLHPLCLPGTTLHPLQLSQIRPPEATNDPLLNHTNQFASTSNAPEMINTVASSYALEPSIRSHFGPFPLLTSPVEMSREGGLTHPRLNIGHSNANITGEQALFDGQPDLKDRIT
The following text describes a protein:
Function:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair (Probable).
Subcellular Localization:
Nucleus.
Sequence:
MGVSGLWDILEPVKRPVKLETLVNKRLAIDASIWIYQFLKAVRDKEGNQLKSSHVVGFFRRICKLLFFGIKPVFVFDGGAPSLKRQTIQKRQARRLDREENATVTANKLLALQMRHQAMLLEENNKKATALANASVQNERQMPSSMTLDNSEIKPVLNQRKNYLKPDPYQLPEMDVSFDKLGSSYDPRIMSQDELTQYVSSFTKIEDINLFDFSNIDFDSELFQSLPDTDKYSILSAARLRSRLRMGLSSEQLSEMFPNRMDFSRFQIERLKERNDLTQRLMDFTGMNEFGPSRVVSEKNREYILVKNEGAEGGWALGVISGSTNNEPIIIDDEATKLSSNLIDEDEDEAFYDVPLPSRSHSMNPRELVAAKLKEIKENSFSENQQSDEADYNVTDDLILQLATQQSLEENKKSKELFSLSASEFDKLNSEKKTFEILSTDIPAEDSMNSLLNDEENLKLEHVGDVSNDSLAFAEKKHPENGTSIFMDALPSASREKKTNDLIDPLPFQPMDWGKSIFFEKLKKPTETFMDSKTDIPSEAPDNSKLVEDTNLHTINATVNIESDLDAAKPGIENPIISPLLPVKDDEKDLDLRELNPLEPFENMKEQADDGTVTNPLNVSSDKAMSVYLLSSENAKDTGDIKSESIDAVLPTLETSSPSLSIPTDFQKEASPNKGAAALSSKVEPEVVEKLLDEEEEEMIIRMAEEEKEYDRFVSELNQRHETEEWNQEAFEKRLKELKNQKRSEKRDADEVTQVMIKECQELLRLFGLPYIVAPQEAEAQCSKLLELKLVDGIVTDDSDVFLFGGTRVYRNMFNQNKFVELYLMDDMKREFNVNQMDLIKLAHLLGSDYTMGLSRVGPVLALEILHEFPGDTGLFEFKKWFQRLSTGHASKNDVNTPVKKRINKLVGKIILPSEFPNPLVDEAYLHPAVDDSKQSFQWGIPDLDELRQFLMATVGWSKQRTNEVLLPVIQDMHKKQFVGTQSNLTQFFEGGNTNVYAPRVAYHFKSKRLENALSSFKNQISNQSPMSEEIQADADAFGESKGSDELQSRILRRKKMMASKNSSDSDSDSEDNFLASLTPKTNSSSISIENLPRKTKLSTSLLKKPSKRRRK
The following text describes a protein:
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.
Sequence:
GWGGETGAERGHSSFLSLRGASGAPCSGGARGGGGGAACLLRGTREGGAEDGERRPRPLARAGDDDGAPVRAALRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE
The following text describes a protein:
Function:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Sequence:
MSTPSLEPESFPNKRFHSSTPALELPPTPEEPIPVDPLAQHRAVFFETLENGCLSALQLTLGNVEPEVKAWLTESHNERGETALVVAIRRRDLSFVKYLMDDLKVDTCRIGNLTWNGVEYLDIPPLLMAIICADFYIFKYMLEYQHLNLVDERAGINEILASLQPRQEKINVLELLGAAYIHHDLVHPRNNNQTTRRRGLQYWREAMNLRHHSSVEPPIPKILPPTSDISRKAMGFSFEITTPQQLEQLDNANNNIQLFTQAIWAIQRIMSQLIPEPHSFTLYRLYTYAYEFYDAGQYSRVVNILMLMLEPFRQQPSDCWDINFSIIGALDIMNDSFKRLNKMPPLSQQGLEDFSFDNLMTAFDFAVAVNRQDMREELAPAAKTRLDTCLYDIVLNLTEMLPKLSQEDGHRFKKALYHFIGANHQFNYFDQGDILHVACRRAPISLDLIQLLLDLGADANSVCAKGNTPLHLLAMINCQVWSPTTTDAVQKLLDFGAHIDQPNRSGRRALGILKAKHRQLCLQGLPDVKLQSLLNNNVLPLTCLAAQVVRKNRIPFEDGQVPVDLHSFIRRH
The following text describes a protein:
Function:
Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis.
Subcellular Localization:
Cytoplasm. Nucleus. Note=In males localizes to the nuclei and cytoplasm during tail tip morphogenesis. In hermaphrodites localizes only to the cytoplasm during tail tip morphogenesis throughout the L4 stage.
Sequence:
MNGLLHMHGPAVKKLLGWKIGEDEEKWCEKAVEALVKKLKKKNNGCGTLEDLECVLANPCTNSRCITIAKSLDGRLQVSHKKGLPHVIYCRVWRWPDISSPHELRSIDTCSYPYESSSKTMYICINPYHYQRLSRPQGLNSSMPSPQPISSPNTIWQSSGSSTASCASSPSPSVFSEDGGEVQVHQRPPPFRHPKSWAQITYFELNSRVGEVFKLVNLSITVDGYTNPSNSNTRICLGQLTNVNRNGTIENTRMHIGKGIQLDNKEDQMHIMITNNSDMPVFVQSKNTNLMMNMPLVKVCRIPPHSQLCVFEFNLFFQMLEQSCNDSDGLNELSKHCFIRISFVKGWGEDYPRQDVTSTPCWLELRLNVPLAYIDQKMKQTPRTNLMEPNSMT
The following text describes a protein:
Function:
Intracellular vesicle trafficking and protein transport.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MKLKMKMFTRQDPNSFLHLSHPSKPSLFYTLERERERETDGQQERETKHHKIQIFLMGSSSSPSATPYINGEIKGGWKRSQISPTSYDYSFKILVIGDSGVGKSSLLLSFISSSEDPLQDISPTIGVDFKMKMLAVEGKRLKLTIWDTAGQERFGTLTSSYYRGAHGIILVYDVTRRETFTNLSEIWAREVDLYSTNPDCVKILVGNKVDRDVERAVTVEEGMALAKEHGCLFYECSARTRANVQQCFKDLSLKILDKPGLLEQGSVVVKRQILKEKQLSLKKRSDNCCS
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MFVTEEERETAGNTTVKYHGKWPLRRAFRIEGCGNDMELDYSSAAIVIGFSLIVSILKAFSIKSEATRVMVAAPLIAFVTNHILYLKCYQFDYDLNMKACAMMGVAKVLISGVWARISNHPFEWKIWVVTIGEGLIILFQIYDFPPYKGFLDAHAISHAIVVPVSYIWWSFIHDDSEYRTKTLMRKAK
The following text describes a protein:
Function:
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
Subcellular Localization:
Secreted.
Sequence:
MKFSYSFVQVVTLLLSLSPSVEGFTRSRNDACKPNHPFRPLPPSQPRTKTCHVVSNGHGKDDSKNIMKALHKCNNGGKVVFDANKVYTVGTALDMTFLKHIDLEVLGKIQFTNDTDYWQANSFKHGFQNATTFFQLGGEDVNVYGGGTLDGNGQVWYDLYAEDALILRPILFGVIGLKGGTIGPLKLRYSPQWYQLVANSSDVIFDGIDISGYSSSKNEAKNTDGWDTYRSDNIVIQNSVINNGDDCVSFKPNSTNILVQNLHCNGSHGISVGSLGQYKGEVDIVQNVLVYNISMYNASDGARIKVWPGVSSAMSEDLQGGGGLGSVKNVTYNQMYIENVDWAIEVTQCYGQKNLTLCNEYPSNLTISDIHFKNFRGTTSGKRDPNVGTIVCSSPNVCSDIYAENIDVKSPKGTDNFVCTNVDKSLLDVNCA
The following text describes a protein:
Function:
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Sequence:
MKIIFMGTPTFAVPSLEKIYKEHEIISVFTKVDKPNARGKKINYSPIKEFALANNLKIYQPENFKDNTLIEEIRNMQADLIVVVAYGKILPKEVIDIPKYGVINLHSSLLPRFRGAAPINAAIINGDTKSGISIMYVEEELDAGDVILQEETEISDEDTFLSLHDRLKDMGADLLLKAIELIKKGEVKAQKQDKKLVTFVKPFRKEDCKIDWTKTSREIFNFIRGMNPIPTAFSNLNGTIIKIYETKINDKVYNNATCGEVVEYLKGKGIVVKTSDGSLIISSAKPENKKQMSGVDLINGKFLKIGEKLC
The following text describes a protein:
Function:
Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
Domain:
Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
Sequence:
MKTTISVIKADIGSLAGHHIVHPDTMAAANKVLASAKEQGIILDYYITHVGDDLQLIMTHTRGELDTKVHETAWNAFKEAAKVAKDLGLYAAGQDLLSDSFSGNVRGLGPGVAEMEIEERASEPIAIFMADKTEPGAYNLPLYKMFADPFNTPGLVIDPTMHGGFKFEVLDVYQGEAVMLSAPQEIYDLLALIGTPARYVIRRVYRNEDNLLAAVVSIERLNLIAGKYVGKDDPVMIVRLQHGLPALGEALEAFAFPHLVPGWMRGSHYGPLMPVSQRDAKATRFDGPPRLLGLGFNVKNGRLVGPTDLFDDPAFDETRRLANIVADYMRRHGPFMPHRLEPTEMEYTTLPLILEKLKDRFKKESDVYKAKESIYAKEESQGHD
The following text describes a protein:
Function:
Plays a role in mitochondrial morphogenesis.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSELSVEPKRLSPIDELISPTVRVIREVYEGENAHEMFQSDLNKALFDKVRFIVIEPTRLGEETERWIAVGNCLHKTALISGTASIAISLIWREKLTIYSASFCAVSMFCTSLYAICWTCDPCVEYQVERKQRNLMKIPVPEGASSPVVLVHKGNRLATYSHRIVTTLAASVCVWTIYRALK
The following text describes a protein:
Function:
May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLTAVALESEKMAAAVEKILGEQYYKDAMEQCHNYNARLCAERSVRMPFLDSQTGVAQSNCYIWMEKRHRGQASAPGQLYTYPSRRWRKKRRAHPPEDPRLSFPSLKPDPEQMLKKEGLIPPDGSSLEALLRSDPIEKRIIPDPRDDDSLTEFPTLSRSARKVQAYGERQRYVAKGIITRILEPDDFLDDLDDEDYEEDTPKRRKGKSKGKGIGGARKKLDAAALDDRDKPYACDNGYKLKQTSKFPERVCGKRYKNRPGLSYHYAHSHLVDEEGAGAEDKEDSQPPTPIMHRSEEQKSKKGPDGLALPNNYCDFCLGDSNTNKKSNQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNICGTSENDVCLHPFAGVHPIQTRISCCSVTTVTVVIICIAFPRLLLNHLKEAGVVTCVWIF
The following text describes a protein:
Function:
Bifunctional enzyme involved in flavonoid metabolism.
Sequence:
MEKGNGVIVCVTGGSGYLGSCLVRKLLHKGYTVHATLRNLGEKSKTSLLKSLPSAETRLKLFEADIYNPQEFETAIDGCQYVFHVATPMLHTPYKDTSEAVVAGVKSIAEYCLRSQTVKRLVYTSSVLMAASPLTEDGSCFKEYIKSKTLSEKEILRYNNEKRSEGEMEVVSLACGLVGGETLLSYLPSSLPVVLSQLTSDQIYLRQLRFSQELMGSIPVVHIEDVCDAHIFCIEKSSLKGRFLCAAESRTIEEIAICYQEIYPLCQIQEGFECEPRGGSKCDLWKLRKEGFKFKYRLKEILNDSVQCAKRLGFLQDF
The following text describes a protein:
Function:
May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
Subcellular Localization:
Nucleus.
Sequence:
MKEDQVVQEESGFQDEEESLFQDIDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCGEHQMELLDYVAAKFHEEAGIFKLLIVDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITTGGIGDAKE
The following text describes a protein:
Function:
Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MGSQLKNKRLHLNPNWAQLQQKLKSHDSKPQRRSKGSQTENPKTILGKRKERPNVELDDSPINPLAPINDDISVTDVVAMDCEMVGVSQGNKSALGRVTLVNTWGNVVYDEFVRPVDRVVDFRTEISGIRPRDLRKAKDFWVVQKRVADIIKGRILVGHALHNDLKVLLLSHPKKDLRDTSEYQPFLREGGRRALRHLAAQFLGVQIQNGEHCSIQDARAAMLLYQKNKKKWEKSVKDQMHLKQKQKKRKQKKKIKQGDVTIDSVPTAL
The following text describes a protein:
Function:
Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response.
Miscellaneous:
MISCELLANEOUS: 'Niban' means 'second' in Japanese.
Subcellular Localization:
Cytoplasm. Membrane; Lipid-anchor.
Sequence:
MGGSASSQLDEGKCAYIRGKTEASIKNFSPYYSRQYSVAFCNHVRSEVEQQRDLTSQFLKTKPPLEPGTVLYEAELSQFAEDIRKWKDRYIVIKNDFAVESYESKEAYQRGAVPKSRILPAGGKVLTSEEEYSLLSDKHFPDPTASSEKNSQPFVLLPKAFPVYLWQPYLRHGYFCFHEAAEQQKFSALLNDCIRHLNHDYMKQTTFEAQAFLEAVQFFRQEKGHYGSWEMTTGDEVQVLSKLVMEELLPTLQTDLLPKLKGKKNDRKRAWFGLLEEAYNLVQHQVSEGLNALKEECRALTKDLEGTIRSDMDQIVTSKNFLTGKIRAMVAQPAEQCCGESVQPFLASILEELMGPVSSGFSEVRALFEKEVDELSQSFHATQDSAQLKEGLQQLMKLPLDSVKMEPCYTKVTLLPERLLDLQSRFRFPHVDLVVQRTQNYMQELMENAVFTFEQLLSPYLQGEASRIPVAIEKVKLRVLKQYDYDSSTIRKKIFQEALIQITLPTVQKALASTCKPELQKYEQFIFADHTNMIHVENVYEEILYEILLDETLKVITEAAILKKHNLFEDNMALPSESVSSLTDLKTAMGSNQASPARRVSAILPGAPDNELPSNEVFQEPEEKKEQPGVPGSLAISASSCPSGGDGQVSVDHSAGGPLTVENTAGPLSSHLSEVEAGGTLKDEEPTCQSPEPSAVPGSLKELKKLLTVTVSVESAPVVENDIHNGTPVPQENIKEEESKIHPEASHPAAIQQDSCEEREVREKEAQPLEAEAPGVDLGILPEGRGSTSQSTSGGLTENTSCPGPIEEPFEAQEPAEKVLPAIVSTEDSPQAGGEAEHSVTVTPQEDATLSSNPICPMESNEVAQASGDQEVLGGEDSSALGMDTEQVNDTHEHACQWLVEDTLSTDILAVHDFDVSSPEQPSEEW
The following text describes a protein:
Function:
Magnesium-independent aromatic prenyltransferase that catalyzes the irreversible transfer of a dimethylallyl group to 4-hydroxyphenylpyruvate to produce the ring A structure in the clorobiocin biosynthesis pathway. Clorobiocin is an aminocoumarin family antibiotic.
Sequence:
MPALPIDQEFDCERFRADIRATAAAIGAPIAHRLTDTVLEAFRDNFAQGATLWKTTSQPGDQLSYRFFSRLKMDTVSRAIDAGLLDAAHPTLAVVDAWSSLYGGAPVQSGDFDAGRGMAKTWLYFGGLRPAEDILTVPALPASVQARLKDFLALGLAHVRFAAVDWRHHSANVYFRGKGPLDTVQFARIHALSGSTPPAAHVVEEVLAYMPEDYCVAITLDLHSGDIERVCFYALKVPKNALPRIPTRIARFLEVAPSHDVEECNVIGWSFGRSGDYVKAERSYTGNMAEILAGWNCFFHGEEGRDHDLRALHQHTESTMGGAR
The following text describes a protein:
Function:
Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
Miscellaneous:
MISCELLANEOUS: Present with 6630 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MSEGKVDEFMAITGADDAAIATQFIEMADGNLNTAISLFFENGGAALLSSNNTPTPSNSTPMAPTSVDSDADAQLAERLQREAYQQQQPDQDYVRPPDEARHEVLTETSGFPISYGGIGGRFEPLHRVNDMFDEGRPESIFNQRLDDTNTNTYINDNSSDSLDSEEENDDDEYEYVEEPVIELDEDGNIKEYTKLVRKPKTISKEQKLALLFRPPFSIMSKLDLDAAKQKARAKQKWIMINIQDSGIFQCQALNRDLWSSRPVKTIIKENFVFLQYQYESRNAQPYLQFYHLNNKDDLPHIAILDPITGERVKQWNRVVPIPEQFISEINEFLASFSLDPKVPNPTVNEPLPKVDPTTLTEEQQMELAIKESLNNNSSKSNQEEVPSTGEEQKRVQEPDPFSTIEARVHPEPPNKPGITTRIQIRTGDGSRLVRRFNALEDTVRTIYEVIKTEMDGFADSRFTLNDHQREDLIDKLNMTIADAGLKNSSLLLEKLDPEIE
The following text describes a protein:
Function:
Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
Sequence:
MADHTVTDRLVEANERYAAAFADPGMDARPVQRVAVVACMDARLDLHAALGLKLGDCHTIRNAGGVVTDDVIRSLTISQRALGTRSVALIHHTGCGMETITEEFRHDLELEVGQRPAWAVEAFRDADQDVRQSIERVRTSPFLLHTEDVRGFVFDVKTGLLREVDPA