The following text describes a protein:
Function:
Highly reducing polyketide synthase; part of a cluster that mediates the biosynthesis of a yet undetermined secondary metabolite (Probable). With esterase AN6793, produces a pathway intermediate compound with molecular weight 258.
Domain:
Multidomain protein; including a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a dehydratase (DH) domain that reduces hydroxyl groups to enoyl groups; a methyltransferase (CMeT) domain responsible for the incorporation of methyl groups; an enoylreductase (ER) domain that reduces enoyl groups to alkyl group; a ketoreductase (KR) domain that catalyzes beta-ketoreduction steps; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.
Sequence:
MQSAGMHRATAEPIAIVGLSCKFAGEASTPDRLWEMLAAGRSAWSEIPPSRFNLKGAYHPSADRTNTVCFNSLCRGNPTEEKKVHVRGGHFLEQDLGLFDAQFFSFSAETAASMDPQIRLQLESVYEALENAGITLPDVAGSNTAVYAAVFSRDYRDGIIRDEDRLPRFLPTGTGDAMFSNRVSHFFDLRGPSITLDTGCSGGLVALHEGVKSLRTGESDMALISGEGLTDEGRFFSPDGKSYAFDSRANGYGRGEGIATIVIKRLSDAIIAGDPIRAIVRESGLNQDGKTETITTPSEEAQVALMRDCYRRAGLDYADTQYLEAHGTGTSTGDPIECRAIATVFKDSRSSEQPLRIGSVKTNVGHTEAASGLASLIKVVMALEKGKIPPSINFEKPNPKIALDEWNLRVVTTLEDWPAGPGGVRRASINNFGFGGTNAHLIVESQAAQPLPWQADGYGASATNLDSQIFVFSARDKQACVNMVNNLKKYLRQNAATDSPDFLLQRVAYTLGQRRTRFPWVTARPVPVQNGFREAIQALEVNMPVPRRTTGIPRIGMVFTGQGAQWYAMGRELIAAYPVFKASLKETDRHLAALGARWSVIEELNQDIPASRVHDVEYSTPLCVAVQISLVRLLRSWGVKPVAVTSHSSGEIAAAYAVGALGCQDAMAVAYHRALLATRSSLGSKQGAMLVVGMSLEETETYLARIDAQIGIATVACVNSPSSITVSGDQDAVNALEALARNDGIFTHRLKIHTAFHSHHMNPIADLYRSALQGALSPNHDKVESDITFSSPVTGRRITNLSQLSEPDHWVDSLLKPVQFVDAFTDMVLGASGASSANVDLILEVGPHTALGAPIKQILAEPKFAGLDISCLGSLVREVSAVRSMHSLAASLVAEGLPLDLDAVNFPHGRPPSVRALSDLPSYPWNHQTRHWYESRFNKGLRERAQPPHDLLGSLVLGTDPNSPTWRHILKLKDAPWLREHVVQEDILFPGAGFICLAIEAIKMLPELQSKAPQAAAGYRLRDVDLLQGLVIPDNDDGVEIQTSLSEVSDKEMGNRGWKRFEVSSVSADNQWSTHARGLITMEPEDAPDKTITKSRPADLSGYTRRFGPSDLYDMMRERGIYHGPAFQIITDIEQAGNNQRADSSLFIPDTAIPADSPYQTLIHPITLDAAFQTVYAPLLGGKEWDDAIVPRTLGSLWISNSISQAAGHRFKAFAILHHSDARTMRSDIYMADNNSDASPVLMVRNAVFQSVGRSAAPQQVKAQWESEPCTNVVWGPDMSLLSTPMRAQLKQQLSHPPEAEEARLLADLRRACLYFIYDALSSLRPFELRKLPSHHAKYHSWMQVQVSLAAECRLAEDSARWSSDTQEQRQSLIERVGRSSVNGEMVCKLGPHLAAIIRQEKMPLELMMENNMLNHYYQNALKCDRILSQAAHILQNLIHKNPRARILEIGAGTGSFTRYALPKIGTAATGGPLAELYHFTDISPAFFEAAREEFAAWDDIMVFEKLDIEQDPASQGYDMESYDIVVAVQVLHATTSMSKTMSHVRKLMKPGGHLLLVETTHDQLDTEFAFGLLPGWWLSEEPQRALSPSMSVPLWDETLKAAALSGVDFEVRDCESDEWYMMSVITSTAVPAHQLTLNPDSIVFVERKDAPCRQRWLEILRSNFAAAGQSPPVVEFETATAESYKGKWTVFLGEVDKPLLYDLDATGLKNIQTMIKHSRSLLWVTRGGAVKCERPELSLATGFLRSIRHEYAGRRFVTFDLDPHESLWSDTSTADIAKVMTTSFGSAADNAQTPPPYDFEYAVREGVILVPRLFRDSARNQAINPASVCWASPEALPTESFFQSNRTLALKVGVPGLLDTIAFDDDPAALADCTQLPPDLVEIKPRAYGVNFRDVLVAMGQLEERVMGVDCAGVITRVGCQAAAHGYAPGDNVFALVRSGYSSRPRVEWTNAMHIPQGLSFEQAASVPAIFTTVYLCFYKIARLQRGQTVLIHAGAGGVGQTAIQFARHIGAEVYTTVGSAEKRELLIQRYGIPADHIFSSRDASFADGILEATNGRGVDVVLNSLAGPLLQASLNILAPFGHFVEVGKRDIEQNSHLEMRPFSRHITFSSFDLLALSQHDKRSIHSSLIEIRRLLEEGAISPVYPVSTYPLGDIGKVFRLLQVGKHSGKVVLSISPDEQVRVVPQARTAKLRSDASYLLVGGAGGIGRSMAHWLAAHGAKNIIVLSRSAGTSPAVAELVAELQPLGCHVKPISCDASVKADLAAALSSCSAELPPIRGVIQAAMVLQDSVLERMTFEDWQTSLNPKVRASWNVHTQLRDADLDFFVFLSSMSGIYGYTTQSNYSAGNTYEDALAHWRVSQGLPAVSMDLGPVKSVGYVAGVAGVADRMTKLGHFPVTEEQVLRVLETAVLSPFDKQVAMGINQGPGSHWHPVGPSPLGRDARFRSLQYQKSTQRQATNGYSNASTSLASRLSDAKTRQQAEKLVVEAIASKLADIFMIPVAHVDAAKHLSEYGLDSLSAVELRNMLALQAAADVSIFSIMQSESLAALASEVTRKSTHVPASLSVM