lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Part of the tripartite efflux system PvdRT-OpmQ required for the secretion into the extracellular milieu of the siderophore pyoverdine (PVD), which is involved in iron acquisition. The system is responsible for export of newly synthesized PVD after the final steps of biosynthesis have taken place in the periplasm. It is also responsible for recycling of PVD after internalization of ferri-PVD into the periplasm by the outer-membrane receptor FpvA and release of iron from PVD, thus making PVD available for new cycles of iron uptake. In addition, can expel unwanted metals complexed with PVD from the periplasm into the extracellular medium.
Miscellaneous:
MISCELLANEOUS: Was originally thought to be involved only in PVD recycling. It was later shown to be involved in the secretion of both newly synthesized PVD and recycled PVD.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MSMKNLSLISACLLLGACGSTPAPLDSGLAAPSQWRYLAAGRSDASDIRQWWKAFGAPELDSLLQRALLNSQDLGAAVARVRQAQASAVIAGAPLLPELNATLGASRQKLLRDSGYSGTDATSDNDAVDSFSAGLSASYEVDFWGGRQAAYRSALESLKASEYDRATVELTLLSGVANSYLQVLALREQQRIARLNLDNAEHVLRLVETRHAAGSATALEVAQQSSLVASQRKQLPLLEQQAHEALITLATLIGEPVQALQVAERPFDSLRWPETGAGLPSELLSRRPDIANAEAQLAAAQADVQVARAALFPKLTLSASLSSGANRAADTFRNPYYNLGANLLAPIFNHGRLRAERDRSLARQEELLETYRKAILTAFADTERSLNSIDGLDRQLHWQQQELEQAQRAFDLSDSRYQAGAETLLTVLETQRTLYAAQDAAVQLRLARLQASVGLYKALGGGWQSDRQGLARKD
The following text describes a protein:
Function:
N-glycosylase that inhibits protein synthesis by depurinating ribosomal rRNA, and thus acts as a ribosomal inactivating protein (RIP). Has adenine polynucleotide glycosidase activity on the poly(A) substrate A30-ssDNA. Inhibits cell-free translation in rabbit reticulocyte lysate system with an IC(50) of 1 nM. May function in the defense response to pathogens. Displays antifungal activity against C.comatus and P.piricola, but not against R.solani, M.arachidicola and C.gossypii. Inhibits mycelial growth in P.piricola with an IC(50) of 2.5 uM. Has cytotoxic activity against the human cancer cell lines Hela, HepG2, and JAR, with IC(50) of 358.8, 489.8, and 926.9 nM respectively. It also inhibits HIV-1 reverse transcriptase activity (IC(50)=7.9 nM) and disrupts mouse embryonic development.
Sequence:
ITFQGCSPARQTVITNAITRARADVRAAVSALPTKAPVSTFSTWFGVYND
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Subcellular Localization:
Cytoplasm.
Sequence:
MPKVIGLTGGIASGKSTVSELLSVFGFKVVDADKAAREAVKKGSKGLAQVREVFGDEAIDENGEMNRRYMGDLVFNHPEKRLELNAIIHPIVRDIMEEEKQEYLKQGYNVIMDIPLLFENELENAVDEVWVVYTSESIQMDRLMQRNNLSLEDAKARVYSQISIDKKSRMADHVIDNLGDKLELKQNLERLLEEEGYIEKPNYGEED
The following text describes a protein:
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
Sequence:
MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILSSCLTMPKLRVLELQGLGWEGQEAEKILCKGLPHCMVIVRACPKESMDWWM
The following text describes a protein:
Function:
Involved in cytokinesis and septation where it has a role in the localization of F-actin.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSWNFFSRFTGASPKKTVLTREEEKDFETEVNKIEVLDEATKRLYKDMRKCIEAMTSLSKHQCRVAHNLAASPILNTEPDIKSLEGISTSISKVDEFTHELNLSATRTMVEPMKKFSGIFPGIYVALKKREQILQEYSRCQTKLEKYQDKERTGPNLAKLEQSKKTLDAAKEEYEKVHQELMEGMPNFFEARINYFQPCFEALIKAQVQYYTECFKIYVEIAASLQHNETVQSDDDFEEELHSKLNDIRALSIVVDD
The following text describes a protein:
Function:
Glycosyltransferase required for the biosynthesis of heparan sulfate. Initiates heparan sulfate synthesis by transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core linker (GlcNAcT-I activity). In association with rib-1, is also responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (GlcNAcT-II and GlcAT-II activities). Required for normal ventral epidermal enclosure during the early stages of embryonic development. In addition, involved in the elongation of the pharyngeal isthmus during the later stages of embryonic development. Involved in the directed migration of hermaphrodite-specific neurons.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MAIKLNGSSRSFVPSLRVSAFLIFIFFVITYIIIYNVSFSEPSWITQDALKQNIENLDDYDASCSGYSIGRILREQKRILASVRLELTESQVKIEEIRTVQEELQRLIPQKQLELSALEGEIEAAQRQLEELRETQNVKVFLPFSPLQIPRELEQPSQISPNQLDDIIDYSRCSISSFMPVYVDIITSGQSEKEWLNVFQEVIPNLVETPDKACIKIHISNGIASPNTTFNSILFNVGSPIINFQSKSIHVQASKIRSFDFPVDVNHIAVEKVDLTPLLPFQRENLISLIVDNTELNFSAFSSLSAEPSRRPIVIVKCSQENCSLERRRQLIGSSTFCFLLPSEMFFQDFLSSLQLGCIPIILSNSQLLPFQDLIDWRRATYRLPLARLPEAHFIVQSFEISDIIEMRRVGRLFYETYLADRHLLARSLLAALRYKLQIPTREVRRNQAIPLFNSSFTAPKGSVVNVQANFDDEYLLGPLESRVESTSYAYNFTEFQLYSYDFWNIIMSPHYTKEFLVNAAELPTEAEFFEDTKIGFRPIEPGSGAEFSKALGGNRQREQFTVVLLTYERDAVLTGALERLHQLPYLNKIIVVWNNVNRDPPDTWPSLHIPVEFIRVAENNLNNRFVPWDRIETEAVLSLDDDIDLMQQEIILAFRVWRENRDRIVGFPARHHARYGDSMFYNSNHTCQMSMILTGAAFIHKNYLTAYTYEMPAEIREHVNSIKNCEDIAMNYLVSHLTRKPPIKTTSRWTLKCPTCTESLYKEGTHFEKRHECMRLFTKIYGYNPLKFSQFRADSILFKTRLPQNHQKCFKYV
The following text describes a protein:
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
Subcellular Localization:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus.
Domain:
The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a C-terminal globular domain with a histone-type fold.
Sequence:
MADHNPDSDSTPRTLLRRVLDTADPRTPRRPRSARAGARRALLETASPRKLSGQTRTIARGRSHGARSVGRSAHIQASGHLEEQTPRTLLKNILLTAPESSILMPESVVKPVPAPQAVQPSRQESSCGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSVFQQGVDQGLSLSQEPQGNADASSLTRSLNLTFATPLQPQSVQRPGLARRPPARRAVDVGAFLRDLRDTSLAPPNIVLEDTQPFSQPMVGSPNVYHSLPCTPHTGAEDAEQAAGRKTQSSGPGLQKNSPGKPAQFLAGEAEEVNAFALGFLSTSSGVSGEDEVEPLHDGVEEAEKKMEEEGVSVSEMEATGAQGPSRVEEAEGHTEVTEAEGSQGTAEADGPGASSGDEDASGRAASPESASSTPESLQARRHHQFLEPAPAPGAAVLSSEPAEPLLVRHPPRPRTTGPRPRQDPHKAGLSHYVKLFSFYAKMPMERKALEMVEKCLDKYFQHLCDDLEVFAAHAGRKTVKPEDLELLMRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAYSGNSVFPAQ
The following text describes a protein:
Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MDPLNLSWYDDDPESRNWSRPFNGSEGKVGKPHYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSVVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNYTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTANSPVKPEKNGHAKDHPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNVEFRKAFMKILHC
The following text describes a protein:
Function:
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Sequence:
MEFGTVKMYYEDNPDSCDEAIPLPNVTSKYLAKVIEYYKWHVEHRAKKAPKPVKIKFLQYEEEEDEEAKAFDKALFNTLDNEGMKQMIMAANYLDAKDLLEMLTQAVADRIKK
The following text describes a protein:
Function:
May be involved in transcriptional regulation. Positively modulates wnt-beta-catenin/ctnnb1 signaling. Required for embryonic neurogenesis. Required for progression through late erythroid differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MFQLPVNNLTRLRKARKKVKRLLSDIGLDYCKEHVEDYKDVDPDDSDDSNESHLDLCTWDPTWTKSQDYRTKQFCCSDCPFASKYFSAYKNHFRNVHREDFESRILLNCSYCTYSGNKRTLETHVRLFHMPHNVMRQGVVGPHGAPVGAKDGMRVDKPMLGDRKELPVYYCKKCTYRDRLYNVVRRHIYREHFQHVATPYLGKNSEKQVNSGEAQANSHGIHCKSCHFTPRSYEALVQHVIEFHERIGHQVTAMIGHTNVIVPRLQTNPIQRGVPITSGVRPQTPQMNRFSMPKVVGLPVGNHFKQSLAGNSVPGQPVRVTLPDKAFVSSAVSHSHSGKHLGGFGVHGAAHLNAQSASFSPSLKSLPLSSSVHAATATLTSLQAKKASANALNTSQTQKWKICTICNELFPESAYSAHFEKEHQAEKVRAMAKYIMKIHNFTSKCLYCNRYLPSDSLLNHMLVHGLSCPHCHSTFHEVEKIVAHNRLAHPNEQGDQPTGSPLTFDLTLQQGNLKNVQLLVTTYNMKETPEAAAAAAAANQLSQNSAMPKPVKVSVRQPDTQSDSLVRNMSQSPVSQKKEVGKTLCPLCFTILKGPISDALAHHLRDSHQVLQTLHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVCQTPKGSKPITTGLRSPGAGSLKRELVTPDPSDPKRRKMVDQSRFYPTGFAEKPEEPIVLALDPKGYGDKSYEVRKAFLTAYFNRHPYPSQREVEKLAASLWLWKSDVASHFGNHRRLCDRDFTSRKPVVLLGFNMRLLSQIKHDMSFDDSCLFEVFDDEKSGYSRTSSFRLKSPIGFPADFIGSKQPLNTGQSSQSNCAFKTCPGSSSEPIAIDSDSDSELEVIPNENVSQHTPALRPSIVQSQTKGALLRESLRCERDVRANRSSPRVGPKVLDGSVSSSSPDEATWSGNMSSEESHYIPAGRFEVKGKKVGLLGR
The following text describes a protein:
Function:
Plays a role in the sugar gustatory response.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MIEVGFGFRMVPGPVRSSNATRHTRSRWHWLRKRGNVTFVRPAAEIDDRKERFYLAIASVLRWARLFGVFPLSNITATDPSAFRFHYFSPYIVLSALSIVGGLFIMAAALVRLNRVGINAMNIAEPIFFGMCTLLQLLFVRLAQAWRGFMVYWAEREEMFFARPYGAINLRRKVIGLAVCILTSALVEHVVYVINQAYNVYQESLTCQYNVTNPLKLYGTLTFGSVYQSVPYHHLLTMYLLYTTISLTFIWTFTDLFIMLVATGIACRFGQLNKRIDSNLQNGSEAFWGEMRTHFVGLIELVERTNRIVGPLLIASCANDMYFLCLQTLNALEDKPYDINDWYFRYSFTFLILRTSVKLWFAADVDENSVRTHKLVQKIRSEHYNDELEILRICSSGGVSISGMGFFTITRRIFLTMAGSILTYELVLMRFHRSSKGVGEDLPCGYID
The following text describes a protein:
Function:
Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
Sequence:
MNEFEDLLNSVSQVETGDVVSAEVLTVDATQANVAISGTGVEGVLTLRELTNDRDADINDFVKVGEVLDVLVLRQVVGKDTDTVTYLVSKKRLEARKAWDKLVGREEEVVTVKGTRAVKGGLSVEFEGVRGFIPASMLDTRFVRNAERFVGQEFDTKIKEVNAKENRFILSRREVVEAATAAARAEVFGKLAVGDVVTGKVARITSFGAFIDLGGVDGLVHLTELSHERNVSPKSVVTVGEEIEVKILDLNEEEGRVSLSLKATVPGPWDGVEQKLAKGDVVEGTVKRLTDFGAFVEVLPGIDGLVHVSQISHKRIENPKEALKVGQEVQVKVLEVNADAERVSLSIKALEERPAQEEGQKEEKRAARPRRPRRQEKRDFELPETQTGFSMADLFGDIEL
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAGEPVVEDQQRQRTLKALERRFEAAQAELDLQKKKTVKRPKTEEAGKKSHIPTSSVVDSSAKSSNASASSSTPSKKGAFTFSGYVNSQDIDESGPTYAKLSQSVHENLLTTNVEVSGRKESKVDKVLHELLQSGDSAQKYMQGSRSKRIDNWILLDNYVQGRGVLTGSRARALQIHSKRSKKCMSIKQLKKHGLFDLPQDFHCFDKFKPMHEMWKDYIVQLLKTTGKNQLAQCLLTADLHGAIISVAECKVTSYTGVSGIMIRETAETFGIITQDDKFRVVPKRFSVFIFQVDCWKITLHGDKLTSRNLSL
The following text describes a protein:
Function:
Isochorismate synthase involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MASLHLSSRFLATNTKKHSSISISHHYSPTPFTRLFSRKKFMSCSMSMNGCEGDFKTPLGTVETRTMSTVLSPTAATERLISAVSELKSQPPPFSSGVVRLQVPIDQQIGAIDWLQAQSEIHPRCFFSRRSDVGRPDLLLDLASDNENANRNGSDRDLVSVAGIGSAVFFRDLDAFSHEDWRSIRRFLSPNSPLIRAYGGMRFDPNGKISVEWEPFGAFYFSVPQVEFNEFGGSSMLAATLAWDDELSWTLENAIEALQETMLQVSSVVVRLRRESLGVSVLSKNHVPTKGAYYPAVEKALEIIKQKSSSLSKVVLARNSRVITDTDIDPIAWLAQLQSEGHDAYQFCLQPPGAPAFIGNTPERLFQRNQLGVCSEALAATRPRAASTARDMEIERDLLTSPKDDLEFSIVRENIREKLNSICDKVVVKPQKTVRKLARVQHLYSQLAGRLRREDDEFDILAALHPTPAVCGLPAEEARLLIKEIESFDRGMYAGPVGFFGGEESEFAVGIRSALVEKGLGALIYAGTGIVAGSNPTSEWNELDLKISQFTKSIESEATTTTLQPIN
The following text describes a protein:
Function:
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
Subcellular Localization:
Nucleus.
Sequence:
MSVISEHQVQLSSFDPIENCVKSTCPGCKSNRKYFCYDCRTPMPGVFTPTVKLPCAVDIVKHPMEKNSKSSALHCKIVAPDQTRVFDYPNVHDYSQDSEDERQGTAIIFPSKSAISVEEFVKTRGPIKRIVVLDCTWFQVGVMQKTPQIQGLQHVSLQSYRTAFWRPQHNVPETGLATIEAIYYSLREYQELGLGRKYSGEFDDLLYWFFHTKHFVDGKQADYLRRKDEERSEEK
The following text describes a protein:
Function:
Part of the ABC transporter FtsEX involved in cellular division.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNKRDQKRFNRLILWIVNHSRACLYGLGELIRTPLASIMTIAVIGVAMALPTGFYLFLQNFQTLSKPWNGKPTISLYLKLNTPDAKINQLITQLKNRSDISNIQYTSAENGLSELKKSMVLDDVINTLSSNPLPPVLTIIPTKNNPAALQQLLLNLKTFPLVDVAQLDFAWVERLHHLITLGQRITDTLAILLSVGVILIIGNTIRLTTDNYRQEITILKLVGATLSFIRRPLLYRGFFYGFLGGCVAWFLVSILLLETASPASLLAATYNYHYVIHGLSIKTGVFIILISILMGLCGSWLAIYRHLNAVERL
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MANWTQEDGAPTPVTNPSEVSQVSGGSVTGGPAVTSCLIPSFAEAVKLLKARYSCLVLDTHRRHISLPPVHLKKKKTGIQEQLNAELLKYSNSLDGVPVAYDNIKVVGQHGNIYDDQGFIHFNIEASFVIFRPKNGSRLMGVINKMGASHVGCLVHGCFNASVMKPNALTSDQWRDSGLCVGQSLEFEVFQLDADAAGVLLIRGRLDRSRVQELVAQFEQKQVTAESSTEADATEDTTDSPKPKKKKKRKKDKNDTESSMEECVNNSSLQETSEHHQTTTEEDCSANGRHKEKKKKKKRDKNDTESSMDECMNNNSLQETALDTTEEDCNANERHKEKKKKKKRDKQQDSAEIVPTSDSSGYISDKTSRKRALEAGDDTETPAAKKKKKSK
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins. Modulates expression of glucosinolate pathway genes. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level. Recruits KLCR1 and calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking.
Miscellaneous:
MISCELLANEOUS: IQD1 overexpression leads to increased resistance against herbivory by generalist chewing and phloem-feeding insects.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm, cytoskeleton. Note=Recruits KLCR1 and calmodulin (CaM2) to microtubules, nucleus and nucleolus.
Sequence:
MVKKAKWLKNVKKAFSPDSKKLKHESVECQDSVISYPVLIATSRSSSPQFEVRVDEVNYEQKKNLYPPSSDSVTATVAHVLVDSPPSSPESVHQAIVVNRFAGKSKEEAAAILIQSTFRGHLARRESQVMRGQERLKLLMEGSVVQRQAAITLKCMQTLSRVQSQIRSRRIRMSEENQARHKQLLQKHAKELGGLKNGGNWNYSNQSKEQVEAGMLHKYEATMRRERALAYAFTHQQNLKSFSKTANPMFMDPSNPTWGWSWLERWMAGRPWESSEKEQNTTNNDNSSVKNSTNRNSQGGETAKSSNRNKLNSSTKPNTPSASSTATRNPRKKRPIPSSIKSKSSDDEAKSSERNRRPSIARPSVSDDETLSSSTARRSSNLIPTTKSARGKPKSQTSSRVAVTTSTTEESSILPEKAPAKKRLSTSASPAPKPRRSSAPPKVEKGVLKAERTP
The following text describes a protein:
Function:
Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSERRVESEPPGHEATPAPSTSETAVSEPIDPESMLDAEVGTPFEHDRLHIVTSTQGVEAVGEIDHFGRMNVQYLRPTADPDVFELDVEPSLNADVQPSDEAEASKDAEEAEASEEVEDADDDGDDELAPLQPSHQSPRRSPRTSPHKRASPQSSRPASELDRDLVDLTDTALVDPSIPISRRDRLLKAAGNEPDFGKHNLHRLFDRDNDGRLSHAEFQSGLLALGMEIDRDNAGTIEEDEFVQFFKRLRMDDITRKLQGFSRRDPVRVKVVSYCASSNHAELNQHVEFDLAQFKDWLDNRHRLQKLGFAFELAAISSSCQRFCSCFRTLLQDSFRVLHHTRPIRSWVTVKGYDPNVADMLSVALDIHEEILQDVVTIQRDKIEIVGPPEKPFAHILASVYAMNNSPIYVPSYGLANVYVKLGPNVKVVTIVRSRWFDVFLLGSGVWDPDVLDSPVYNVVRELEDQIIRRFPDVILGNVKYLAYLFLEAVSELNYDMRDVLKQWLEMIDDGISQTPRPEHRAHLFEYAKVSSLYMREMSALANRLHTLRWDAKVEPFSFFFQNESVQDEQTNNVLLLLTLVTTIFIPAQFLTGLWGMNFEEMPELHWRYGYVMFWSLVAGFTIITILWFRLSGYWQLSGH
The following text describes a protein:
Function:
Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct segregation of chromosomes and for maintaining the inner centromere structure.
Subcellular Localization:
Nucleus.
Sequence:
MKRKPEEQEGFVFVRKGKEKAGSKRRKSSVEDDPDTSQTDGLVELPVSDTPIVKRNKELRKGKGRRSSLDQRGKRASSIGTGFEALPHADVPSHEYYRHISKDLSEPLRIKQLLLWASSKALEEQRKKYGETEEASEAAIARSIVQEVLNELLANKVSVSWYQRPPDAVIPNKPHPQNLKNAQLVDELSAKLTQLHNEEAAWRAVAANSVSSDKSILSFKKAVESIDSKQDLDKQDSPLPPDDAPELPNISKLKPKFHTLLDMLAENIHTLHSLTNAGPEVRSSYGRLAAQDFIAHRKSLLSFSKYVDTMNLLRLLSEASYKSSSNESV
The following text describes a protein:
Function:
Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner.
Sequence:
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
The following text describes a protein:
Function:
Has a role in promoting intracellular monovalent cation sequestration via the exchange of monovalent cations and especially Na(+) for hydrogen ions across the vacuolar membrane.
Miscellaneous:
MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MAKNNHISASGNSTSGDHRLKEEVLTPTTSASTPHRIFSVDDDPKEIQNDIRYLEGLHEGLKFALHANKSKRSVSSQSPIVHSSNNTLHHHEHQQHLPPTLESLSSKSHSVPDLNTATPSSPKRMHSSIRELPHDDNDDEDANDDSRFIIHDSHGHDLLIDEINCQSPSHLENNDQASNASSTESFTLRERQDAINETHPFGIRIWKPALYKKHRSVQRTAAQDIHETQLKTITWEVTCSNVLWFILFGFPIAILFYSAAIVVFLLGGGGLVTNSAKEYSKCLYKLANYFLWPFGKMVYLLQDEQYLQEDKDEGISMQQFYNWVTSYSNRLVFHQSQAKFQQREDHPAPATESSSLMPPANTTATPLNSNHPSYNSIRHEIPHAAAQRRYFGRGKWSWGRVLFYTIFHLVLQPILAVLSLCLWLLVFTIPMSNVLWQIMYHCRRHPLALGFKYVENSSQSHENEITQQQLNKNILLCTFRAAGWHYYKYTVDGTNVIVVNLISIVFFTIFDFYVLKNFLHWKTWFTYESSIFILCLTSTIPLAFYIGQAVASISAQTSMGVGAVINAFFSTIVEIFLYCVALQQKKGLLVEGSMIGSILGAVLLLPGLSMCGGALNRKTQRYNPASAGVSSALLIFSMIVMFVPTVLYEIYGGYSVNCADGANDRDCTFSHPPLKFNRLFTHVIQPMSISCAIVLFCAYIIGLWFTLRTHAKMIWQLPIADPTSTAPEQQEQNSHDAPNWSRSKSTCILLMSTLLYAIIAEILVSCVDAVLEDIPSLNPKFLGLTIFALIPNTTEFLNAISFAIHGNVALSMEIGSAYALQVCLLQIPSLVIYSIFYTWNVKKSMINIRTQMFPLVFPRWDIFGAMTSVFMFTYLYAEGKSNYFKGSMLILLYIIIVVGFYFQGALSE
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRNSEKQGSMLHRFQQQQANAAGLLDVGRTVRPTYISGVESLPQAEKWRSQVMKEISRKVTKIQDPALSDFQLRDLNDEINKLMSERHRWDLQIRSLGGPNYASFGGKKRGYQYYGRARELPGVSEMLQSQKKDDTKKSGDFYIPPKNLNMVYFGYADDNVTGLMEFEKQRESELQDMLAGKPDEDSGFVVGDITVPEEGDLEARLLEERKRRVQALLD
The following text describes a protein:
Function:
Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
Subcellular Localization:
Secreted.
Sequence:
MGWTMRLVTAALLLGLMMVVTGDEDENSPCAHEALLDEDTLFCQGLEVFYPELGNIGCKVVPDCNNYRQKITSWMEPIVKFPGAVDGATYILVMVDPDAPSRAEPRQRFWRHWLVTDIKGADLKKGKIQGQELSAYQAPSPPAHSGFHRYQFFVYLQEGKVISLLPKENKTRGSWKMDRFLNRFHLGEPEASTQFMTQNYQDSPTLQAPRERASEPKHKNQAEIAAC
The following text describes a protein:
Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Confers tolerance to cadmium (Cd) and plays a role in Cd and zinc (Zn) homeostasis.
Sequence:
MGLILTRMILNCGCGSSCKCGDSCSCEKNYNKECDNCSCGSNCNF
The following text describes a protein:
Function:
Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism. Phosphorylates BUB3. Also autophosphorylates. Associates with centromere (CEN) DNA via interaction with SKP1. The association with SKP1 is required for the mitotic delay induced by kinetochore tension defects, but not for the arrest induced by spindle depolymerization or kinetochore assembly defects.
Miscellaneous:
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MNLDLGSTVRGYESDKDTFPQSKGVSSSQKEQHSQLNQTKIAYEQRLLNDLEDMDDPLDLFLDYMIWISTSYIEVDSESGQEVLRSTMERCLIYIQDMETYRNDPRFLKIWIWYINLFLSNNFHESENTFKYMFNKGIGTKLSLFYEEFSKLLENAQFFLEAKVLLELGAENNCRPYNRLLRSLSNYEDRLREMNIVENQNSVPDSRERLKGRLIYRTAPFFIRKFLTSSLMTDDKENRANLNSNVGVGKSAPNVYQDSIVVADFKSETERLNLNSSKQPSNQRLKNGNKKTSIYADQKQSNNPVYKLINTPGRKPERIVFNFNLIYPENDEEFNTEEILAMIKGLYKVQRRGKKHTEDYTSDKNRKKRKLDVLVERRQDLPSSQPPVVPKSTRIEVFKDDDNPSQSTHHKNTQVQVQTTTSILPLKPVVDGNLAHETPVKPSLTSNASRSPTVTAFSKDAINEVFSMFNQHYSTPGALLDGDDTTTSKFNVFENFTQEFTAKNIEDLTEVKDPKQETVSQQTTSTNETNDRYERLSNSSTRPEKADYMTPIKETTETDVVPIIQTPKEQIRTEDKKSGDNTETQTQLTSTTIQSSPFLTQPEPQAEKLLQTAEHSEKSKEHYPTIIPPFTKIKNQPPVIIENPLSNNLRAKFLSEISPPLFQYNTFYNYNQELKMSSLLKKIHRVSRNENKNPIVDFKKTGDLYCIRGELGEGGYATVYLAESSQGHLRALKVEKPASVWEYYIMSQVEFRLRKSTILKSIINASALHLFLDESYLVLNYASQGTVLDLINLQREKAIDGNGIMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPGEPLGAHYMRNGEDGWENKGIYLIDFGRSFDMTLLPPGTKFKSNWKADQQDCWEMRAGKPWSYEADYYGLAGVIHSMLFGKFIETIQLQNGRCKLKNPFKRYWKKEIWGVIFDLLLNSGQASNQALPMTEKIVEIRNLIESHLEQHAENHLRNVILSIEEELSHFQYKGKPSRRF