lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Cell adhesion glycoprotein which is widely distributed in basement membranes. Involved in cell-extracellular matrix (ECM) interactions probably by connecting the laminin and collagen IV networks. Required for permeability and mechanical stability of basement membranes, and ECM dependent neural plasticity. Not involved in assembly of the embryonic basement membrane.
Subcellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix, basement membrane. Note=Secreted in the hemolymph. Localization to the basal membranes depends on laminin.
Domain:
The NIDO domain (also known as globular region 1 or G1) contributes to the localization to the basal membrane probably by binding to vkg; The EGF-like 1 and nidogen G2 beta-barrel domain (also known as globular region 2 or G2) contribute to the localization to the basal membrane probably by binding to vkg; The EGF-like 2-8 domains (also known as the ROD domain) is necessary but not sufficient for localization to the basal membrane; The LDL-receptor class B 1-4 domains (also known as globular region 3 or G3) is necessary for cell-extracellular matrix (ECM) interactions. Also, contributes to the localization to the basal membrane probably by binding to laminins.
Sequence:
MPTFGSKLLACLLLSSVILVSGQFEHYLDSLRASELYEFEDGSLGSIHLLPKGDSETIVLQLEQPIHFYGEQYEQLYINTNGILTFNSEFPEYLNQPFPLEYASIAAFYSNVDTSFSDEGTSISLFESKEQSILDRASSLVRYAFSSQSEFEARQVIVATWRNVGYFDSKTDRLNTFQVALIANEQSTFVQFIYPDGGLNWLQGETAGLGLPDIRAQAGFVAEDGRFYTLNGSGSENARFLSESTNLGVPGVWLFEVAPIENEQNVRSPDNAESLTESPALALSCQAHAHQCHEKAECHDKAEGYCCVCGSGFYGNGKSCLANDQPIRVTGTLTGELNKQPVSEEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQLTGGVYTHVSRLQFDSGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGELKSVQVLNINITEEQRVLGLQVEQRILYRSCLRDDEADPSATKVLQKISKVALDYVERDQALRIGAMSKVGVTPESNACNDGTADCVENSVCVPYEDTYRCDCYHGFAAQLDERGVEVCLDIDECATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRCLSNSTADNIEYPPAVEGQAEPTSEPSPNPSPYPDQGQDQEREREDDQYPQPNPYPYPEEQIPQHPDECYRCSKDADCYQGRCTCHEGFDGDGYTCTNICGHGEVWENGRCEPLLLERHDVDPLCDALGECRCPYGYELSEDSQRCTYVQEFDGERNADLIPCDVDENCHINATCNWYGQELRHICTCQPGFRGDGYNCDPISDDSCAIRPDICDVHADCVYEEHLGKSECQCQAGYTGNGFNCQLAAECQSAEHCGENAFCDDGVCRCQADFERDVSDRCVPAGRCGSVFCGSNAICKWDSAEGVQYCDCLDGYQGDALTGCTSKPLSCHVLNNCGIHATCEPTEDPANYECQCIAGFKGDGYVCIEEQNCLNNPTLCDMNAQCRSTNSGLVCVCNQGFFGNGSLCQERQHQDSDFLIVSQGVMIARVPLNGRNVRPISVAQMAIGLDKDCVEGRVYWGDISTKKIVSTKYDGTDLRPFITTDIESPEGIAIDVISRRLYWADSAKDTIEVASLDDPSLRAVIINKQLVNPRGIAVDPYREKLFWSDWDRESPKIEMSNLDGTGRELLLGKDDVTLPNSLVVLENSGEVCYADAGTKKVECIEPQNRQIRTISNELSYPFGITFTHDQFYWTDWTTKKVEIVDSLGARQTPIQPPFFGSHKMYGMTVVEQHCPQYQSPCQISNGGCTDSRLCLVNRQAPSGKSCKCTSASTGCTVLAPGY
The following text describes a protein:
Function:
Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), drought-induced resistance and rhizogenesis, response to glucose, high light stress, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as the actin reorganization in guard cells in response to ABA. Involved in the resistance to the bacterial pathogen Pseudomonas syringae pv. tomato. Controls negatively fibrillin expression that is involved in mediating ABA-induced photoprotection. May be involved in ABA content regulation. Plays a role in the Pro accumulation in response to reduced water availability (low water potential). Required for the ABA negative regulation of the ethylene-induced hyponastic growth. Involved in acquired thermotolerance of root growth and seedling survival. Activates/represses SRK2E/OST1 in response to ABA-dependent stimuli, especially in stomata closure regulation involving SLAC1. Represses MAPKKK18 activity and promotes MAPKKK18 degradation by the proteasome pathway upon abscisic acid (ABA) treatment. Represses KIN10 activity by the specific dephosphorylation of its T-loop Thr-198, leading to a poststress inactivation of SnRK1 signaling. Restricts MAPKKK20 activity by dephosphorylation.
Miscellaneous:
MISCELLANEOUS: Enhanced ABA signaling repressor activity by the proteasomal inhibitor MG132 accompanied by a cytoplasmic localization; MISCELLANEOUS: Plants insensitive to ABA (abi1-1) are more resistant to P.syringae.
Subcellular Localization:
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Associated to the plasma membrane when in complex with PA, subsequently to ABA signaling.
Domain:
The 'lock' site stabilizes the complex made of PP2C, ABA and PYR/PYL/RCAR receptor by keeping receptor 'gate' and 'latch' loops in closed positions.
Sequence:
MEEVSPAIAGPFRPFSETQMDFTGIRLGKGYCNNQYSNQDSENGDLMVSLPETSSCSVSGSHGSESRKVLISRINSPNLNMKESAAADIVVVDISAGDEINGSDITSEKKMISRTESRSLFEFKSVPLYGFTSICGRRPEMEDAVSTIPRFLQSSSGSMLDGRFDPQSAAHFFGVYDGHGGSQVANYCRERMHLALAEEIAKEKPMLCDGDTWLEKWKKALFNSFLRVDSEIESVAPETVGSTSVVAVVFPSHIFVANCGDSRAVLCRGKTALPLSVDHKPDREDEAARIEAAGGKVIQWNGARVFGVLAMSRSIGDRYLKPSIIPDPEVTAVKRVKEDDCLILASDGVWDVMTDEEACEMARKRILLWHKKNAVAGDASLLADERRKEGKDPAAMSAAEYLSKLAIQRGSKDNISVVVVDLKPRRKLKSKPLN
The following text describes a protein:
Function:
Pseudouridine synthase that catalyzes pseudouridylation of mRNAs.
Sequence:
MCACSGVLQRGTAHDPGRESQWEDRHAGKNASPTLHYQRKRINRAATRKHTEQGMIRAQSARRLVTLDCRSLAALMSEGSLKRKEPNGEPEEGTRKRRHKKHKGAGDGDRFVPPPVKRKVGVSFGDEHFRETESYLENGLRKVRPYYFDFETYCKGRWVGKSLLEVFAKEFRAEPLEYYEQAAQAGRLRLNEVLVRDLNVVLKNNDFLRNTVHRHEPPVTAQLLRILAENDEMVVVDKPPSLPVHPCGRFRHNTVIFILGKEYNLKELHTIHRLDRMTSGVLMFAKTLDVSKKIDEQVRQRQLEKEYVCRVCGEFPEEEVTCEEPIFVVSYKIGVCRVDPKGKPCKTVFQRLSYNGKTSVVKCFPYTGRTHQIRVHLQYLGHPIVNDPIYNTEAWGPNRGKGGEVNRTDDELLWALVEVHKSKQSLDILDISEEDLQPIVGNVGLKSSTEPVQKEPRVPADPQLKDEPQQLTLTENVSFEKTDGSAACRSTEEPRQDSRDSLCGECKIVRADPSPTDLVMYLHALHYKGAEFDFSSEMPDWAQDDWQED
The following text describes a protein:
Function:
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Sequence:
MAADPTLIFLHESFVTFSDALTTEADTWASEVNNWESRKAKLQQLQAGWQARGFHGPEALSTISRYQGHINWQTMPPDQFSRFYRFMFHVCRDPGKRNISMELAVAAWRLVLAGRFRLLERWCTFAAGQQGTKVVTEDTWRQVLDFSRTIHEDLSNYDSAGAWAVLLDEFVDDMRTSRGGGNGGCGRAGLALGGGVSEFGLGGVVAGGMLCGSGGSRDMYLESHRSGSAAELARCSSGGGAGLSGLGGGDGMGFGGGPGGLLGIEGMTAFVSCLSPRCGNKRREPDVDTVAQQLSAIPLGGSVGAAPGQGLAGSGLPPVPLAAPGGGSDGSGWLQGHGAVAMPCDHHTGPKRQCFERPSAEAPPQLPLQPQQPTAHFPTAAHPGVACVHGGSEAPCGPGGFLLGAAPVAPGLGAFAPGPGFGVAAGLGGGSGCLGAAGGGDRAAGGGLCGGSGGATPMSSSGGAGHGGGHMSCCSAGSVDSDCGTAGPAGSAAAMDGLRDASGLCTVATAHSQLLHHHHHHHHHQQQQQMGGRRAVKARRSGVSDIVRSAVSDALGFQ
The following text describes a protein:
Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLYTENEITQAPVVEERTLRSILAREYGIVTGIVHRLTGYEDCNFRLSECRWEERSDGPNEVIVKITNPIEAKDVSVIDAQYEVFSLLRSARIPTPEGIKTKAGEWWTLQELGMGVRLPVRVFRLLPGVNLENFDFTPDLVTEIGRTLASVHRTLDGFPHDISHVPFISPENVQCMRRETEILYRRKLIDDQKKALVDKTFADLDENIFRRRNLFDEGIIHSDFNETNLLVKDGKISGVLDFGDMHISLRVFDVAAAILYLHLSDRLGQRLDDLAAHFVAGYRSARAFVVPNDSLLVAMRARMACSLIYGLRTARINYRGGSIDYVLKTQSNGWETLQRMSARYVLKY
The following text describes a protein:
Function:
May be required for cell division and may have a role during G1 or S phase.
Subcellular Localization:
Nucleus.
Sequence:
MQHVLRTRGNSAQDKNKKHVPNVPPIIYDDMQVPYEKGAFLGEGGFAHCFEFRKLDCNDRLAVKVVPKVILLKSTAREKLTREVEIHRQLSHRNIVQFHHFFEDSQNVYFTLELCSKNSLMELNKQRGPLTEHEARFYTIQVAEGVKHLHNLQIIHRDLKLGNLFLNEHLQVKIGDFGLATFCEKNEKKMTRGGTPNYIAPEVLNETGHAFEVDIWAIGCILYVLLFGSPPFESRRVQETYVRIKNNDYVVPENASPTANRLIRSLLDPVPDRRPTAEAVLLDQFFKTTIEPTYPPVHQQLHKEQDVKYFAPINPVLPHVEEPISPIYQEVANEETSEIRRFVKTEQASSFGDELSQLQAQISHILQNVVASKNKSSTRFGLNHSPEATPIFWVSQWVHFPNHGIGYRLCENSSGMLFNDNTQMKVNSAGNQLTFVDENNTEQFYTMNDQVPMNLQTKINIFSNVQSYMNTHLEADTHLEAEDQCVNKVPPLRNFARLPTIQNWFETKSAVIFHLSNGTVQINFLDHVKMVLCPLLKSVTFIEENKRVSTFTFANILTNSCPKKYLSRIEYAQAKIKLLRPTNNQEHVVYVDSPCRPTTSNTAHGAPLASSRYLA
The following text describes a protein:
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated eif4ebp1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis.
Sequence:
MSVSVHENRKSRTSTGSMNISLYHKLSHSECVLNHLNTMRKQRLFTDMTLWAGNRSFPCHRAVLAACSPYFEAMFSNGLRESLDNTVNFHNSLHPEVLELLLDFAYSSKIIINEENAESLLEAGDMLQFHDVRDAACEFLEKNLYPSNCLGMMILSDAHQCQRLYELSLRMCLSNFATLHNTEDFSSLSKDMLLDLISSDELEIEDEQVVFNAVLHWVKEDLDKRKDYFPELLRNVRLALLPSELLKEAVVCEDLIIADERSKLIMDEAVQCKKKILQNDGVVTSLCAKPRKAGHTLLILGGQTFMCDKIYQLDHKAKEIIPKADLPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTIHEEWSKSAPMLIARFGHGSAELDNCLYVVGGHTAVAGVFPASPSVSLKQVEKYDPLPNKWTMMAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDRVSKVQFYDPHENRWSIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNLWTRIGDMTAKRMSCHALASGNKVYVVGGYFGTQRCKTLDCYDPTSDSWNSITSVPYSLIPTAFVSTWKHLPA
The following text describes a protein:
Function:
Important for the overall degradation of proteins in lysosomes.
Subcellular Localization:
Lysosome.
Sequence:
MAWLLLLAGAALLAPAAASEVTAEEEQLFKAWMLQHGRRYGVGEYERRLRVFVGNKRHIEGHNAGNSSFQMALNQFSDMTFAEFKKLYLWSEPQNCSATRGNFLRSDGPCPEAVDWRKKGNFVTPVKNQGPCGSCWTFSTTGCLESAIAIATGKLLSLAEQQLVDCAQAFNNHGCSGGLPSQAFEYILYNKGLMGEDAYPYRAQNGTCKFQPDKAIAFVKDVINITQYDEAGMVEAVGKHNPVSFAFEVMSDFMHYRKGVYSNPRCEHTPDKVNHAVLAVGYGEEDGRPYWIVKNSWGPLWGMDGCFIAGGGAGKAPEPLL
The following text describes a protein:
Function:
Probable component of a branched-chain amino-acid transport system.
Sequence:
MRDTMEILRTENIVKYFGEFKALDGVSISVNKGDVTLIIGPNGSGKSTLINVITGFLKADEGRVYFENKDITNKEPAELYHYGIVRTFQTPQPLKEMTVLENLLIGEINPGESPLNSLFYKKWIPKEEEMVEKAFKILEFLKLSHLYDRKAGELSGGQMKLVEIGRALMTNPKMIVMDEPIAGVAPGLAHDIFNHVLELKAKGITFLIIEHRLDIVLNYIDHLYVMFNGQIIAEGRGEEEIKNVLSDPKVVEIYIGE
The following text describes a protein:
Function:
Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex. Associates with ints9 and ints11 in the cytoplasm, stabilizing the ints9-ints11 heterodimer and blocking the active site of ints11. Brat1 then joins the complex and plugs the active site of ints11, leading to wdr73 release and nuclear import of ints9 and ints11.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow.
Sequence:
MDISSDESDDWFMESLNAYRDLHLFQLEHPTKVIEWMGDKSICVAGYTGARSEILELLLPLKLYAGDNQGLCAERDFKVKHGGFSEEPVECLIHIPGTRCLVTSGNSNTLQIWDIGGDDSDVIKMTRVINLKSPSAKGSKITPGFTDSPTVLHGSCISDIQLTEIATGRVLHTVGKESSDSVSGLQFVNAFVFLICSTNGALLLGDTRDPSTCHYPLEESNSGLRWSFGLRSDSSQSEPSCCKVARLSSSGHMLLSDLRDLKSPFCQTQIKVPQSASKNHFMNISWAPVLDKCLSVSGFDGTVHIYNTNNWSTESSSPQPIFSHRGHEMSQEAKSSTSPAVVTAHSWHPSRPKTLLSAATDGSLHVWDWVDKITDR
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MPGAMKIFVFILAALILLAQIFQARTAIHRALISKRMEGHCEAECLTFEVKIGGCRAELAPFCCKNRKKH
The following text describes a protein:
Function:
Nucleotidase with XMP as the best in vitro substrate. Low catalytic efficiencies of YKL033W-A observed with XMP and other substrates suggest that these could be secondary activities for this protein, and its primary substrate is not yet identified. May possess pseudouridine 5'-phosphatase activity and together with dTTP/UTP pyrophosphatase YOR111W might constitute a pathway for the detoxification of pseudouridine 5'-triphosphate (Psi-UTP) and -monophosphate (Psi-UMP).
Sequence:
MTHPVAVKACLFDMDGLLINTEDIYTETLNETLAEFGKGPLTWDVKIKLQGLPGPEAGKRVIEHYKLPITLDEYDERNVALQSLKWGTCEFLPGALNLLKYLKLKNIPIALCTSSNKTKFRGKTSHLEEGFDLFDTIVTGDDPRIAKGRGKPFPDIWQLGLKELNEKFHTDIKPDECIVFEDGIPGVKSAKAFGAHVIWVPHPEAHAVLGDTEALLAGKGELLSSLEKLEMSKYGL
The following text describes a protein:
Function:
Transcription factor required for yeast cell adherence to silicone substrate.
Subcellular Localization:
Nucleus.
Sequence:
MKFAKTLERTLEEDEIPQEWVEAAIQYKALKKCINKVVNELEFLGLQKNTLKILLNDKVVEVNEQETNPSNPIIAEYILSKTSTDAHNIKPMLKITLDYSSEDYTKDHIVELGKELKQKIEALLNDSDTEYEEDKIIELKEDDGGDLQIVTSREGSLSPPASRMASPPTSPTLKVVDSLNTNIDEALLSPDDHHKKHEIFIMLNSDSKFFEMLNDELNSLDTLTQQEESKIIEEVKKIAKYVNELKLKQSELYKWRELFKVYLDSEVYFKYNETALPSQQKSSEQIKSNLDLFVTNLNKSGIMTRFKKKQSLETFNQFMEMNYHLLKILQFQTINNEALRKILKKFDKQTSLGIQKTFPKLISNDHIFMSGSSLAQSICYIIQESIIKVIPQLDDYSCPICMNIAYKPIRLSCGHLFCVRCLVKMKQDDKTSCPLCRKENAILYADSSNLDLESMELMKKYFPREVKEKLRERDKERYNELRKNANSGEKCIVM
The following text describes a protein:
Function:
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence:
MLLIWLLLLTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNRFESADAGDPMGALTLPLAKYHHWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGNLFYSLNVGGLRRGRSELITKTKELFNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMRHLVDDHHEPTKGDLINQLQHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLRFCRSSL
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MKRSSFSTGAAGRQSMQALRSQDFNKQGFYTPQTKERTTFGKLNTNRRTPGTSERKISFFGKRTSGPGSRNSLLGVFGGTEKMKDPRPLNDKAFIQQYIRQLCEFLTENAYAYSVSMKSLQAPSVKDFLKIFTFIFDFLWPSYELPVTKFEEEIPRILKDLGYPFALPKSSMYTVGAPHTWPHMVAGLNWLIDCVKLYFSRKESSPSFDDGQPWGPESEDGIMHNKLFLDYTVKCYENFMTGADTFEDLDTELHSKLKDLFNIDDFQVESLVLENKRLNEEIARLERERENEPNRLVSLRKLKTSLKADVQKYQAYMKNLEAHSAVLHQKSSSLNGEVPAAELELEAIKQENARLQNIIDIQKYSVADIERIHHERNEFQQTIKKLTTELEAEQKQLWNEELKYARTKEAIEAQLAEYHKLARKLKLIPKIAENYKGYDFEIKFNPETGTNYPVKYRTQIYIPLKELLNQNEEGISKVLHKKMGSEETLEQVNTMVTEVKRNVKMLNDEVQKLKDLKQQKIKEAEEKEGKCSTEMESLEKHKHLLENGVHEGLSEAMSELDDIQQRQLVLQTTTEERRKVSNNLQRLLEMVATHVGSVEKHFEEQIVRVDKECEEFIAEISLENIKEIVDKYKTKASIISSSE
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Sequence:
MVGSNENSQGVVRPSILRGVMGNNRRALSTINGNIVEAPQYPCKLRKKNGVTDKYVDGEMNPIHRLVTRSDFDSWLRLQIALTVKYFYHFVCFSCNITVDSCLRKYAAQVADKRQQPSLEVTKPVVETAPNGNELEGAINTDVEDYKATSDYVVPMSVQHTEAMMEEIDRMDEEIEMEEIEKALIVDIDRADKKNVLAAVEYIDDIHAYYKKIESSACAPPNYMEQQFDINERMRAILIDWLIEVHYKFELMEETLYLTVNLIDRFLAVQPVVRKELQLVGVTALFLACKYEEVSVPVVQDLILISDKAYTGMEVLEMEKLMINTLQFKLSVPTPYMFMKRFLKAAQSDKKVELLSFFMTELCLVEYETLRFPPSMLAAAAIFTAQCTLGVAKEWTKTCEKYSKYTRDQLLECSKLMVTFHQKAATGRLNAVHRKYSISKYGFVAKMFPPASFLLEASFF
The following text describes a protein:
Function:
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.
Subcellular Localization:
Secreted.
Sequence:
MVTGTPGPCVGNIAPIERLGFSGLCLQDGPLAIRQAVEASVFPAGLSVAASWDRALAHQRGVYMATEFREKGSHIALGPVVGPLGRSPFGGRNWEGFSPDAYLSGVLVEDSIIGMQSTGVQACVKHYILNEQETQRNPSTSNGTTIEALSSNIDDKNSKTLNGLLKEELGFQGYVMSDWAATHSGVASIEAGLDMDMPGGIGFFSGTSSFFGGNVTTAVLLIMDMFRNNGTLSVQRVDDMVLRIMTPYFYLGQDANFPPVDGYTPKLGFFPSENYVSNFTLGPVVDVRKEEHERLIRELGAAGTVLLKNTNGSLPLRQPKRIGVFGNDAADVTEGQYLQSDYDIGTLAVGGGSGTGRFSSLVSPLEAIKTRARSYRAQVQYITSNDVIVSGAMSSIAPLPLDVCVVFLKSWASEGEDRTTLIAEWNSTKVVEETAKVCNNTVVVLHGAAPNTLPWRDHPNVTAILAAHMPGQDTGNSIVDILWGDVNPSGKLPYTIANNETDYAKNLVTSAPLASATNPDAWQADFVEGNLIDYKEFDAANTSVAYEFGFGLSYTTFNLTNMTSSIVVANASRTPNPAAPILPGGNVELWATLATVDVTVNNTGKRDGATVAQLYLSFPDEAAAPVRSLRGFEKVTLPAGGSTRIQFDLCRRDLSYWDVVAQTWRLPQGGVKVSVGFSSRDLVLQGTLAV
The following text describes a protein:
Function:
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity).
Sequence:
MSDDTPHPEWQLVPQGNFVRLSLTLPTVTTAPDSPSLVFSHQQLEQSLGNYLRIMAGRWQDQTLVRLAVNNQLLDARQLQAIAAGLKEQNLTLQWVETNRRQTAVAAASAGLSVDQTMADKPLVDPSETPSLPKPLVVRHTLRSGGEIRHGGDVVIIGDVNPGSSIVADGDILIWGCLRGMAHAGAKGNDQAVIMILRLAACQIRIGDRLARVGADAVDRREPEIAYITSEGIRLTPVRQFQRSALL
The following text describes a protein:
Function:
Involved in de novo DNA methylation. Involved in RNA-directed DNA methylation (RdDM).
Subcellular Localization:
Nucleus.
Sequence:
MVKVEDDVEGSGINASVGDLRDAAVNPQPALLRATVKEEEGQPSSSSSHVRSQFIGMGFSPMLVDRVLQKHGDRDSDTILEALLSQSALQKSGSESGSLGDLFDSDNEENSSHFAPRKEVIQDIKVEADSSSEKRSYLLSTMNFSQREVDLALNQLGEEASLEQLVDFIVTGQVSGCSGGNENGDASNEVKDESLFGVMDKTLHLLQMGFTEEEVSSVIDKAGPEATVLELADTIFARRIASSIEQKEVKVEPDFLDETETSYSAYHPSNSGLRYYDDDHDNIRIKRAKHMFIDDSAGSSSRAGNQPNLDPWLKDHRATTSDGSVKEEFDAMTPGIRRNVRSDVANPPYFLYGNVVEIPKATWRQLSEFLYNVEPEFVNSQFFSALSRKEGYIHNLPTEGRRNLVPRSPMTIEEAFPFTRQCWPSWDTRKQLNSVATEVAGIEQLCERLGKMVRDSGGYLSQEKKTHIMHQCKLANLIWVGPDRLSPLDPQQVERILGYPRKHTNLFGLNPQDRIEAMRYSFQTDTLGYLLSVLKDLYPDGLRVLSIYSGIGGAAIALHRLGIPLQCVVSVDQSDTNRKILRRWWSNTEQKGQLRQINTIWKLKINVLEDLVKEFGGFDIIIGGNFSSCKGGTTVNSSMGMDSNQFFEYVRVVQRVKHIMGRLQVRAHESARHRHRSPSN
The following text describes a protein:
Function:
May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.
Sequence:
MDGKTGDSLIKSMYSDGTLREPSDILKTLKEFTLGARESSFRETLTLHNVRFLTDYFQQCVEALTSQQVFNVECCTECLRCLRNACAQCVENQEAVLRSLAIPAVRQLLRYLVETVSLEEQYLVLLRCCIQFLTNLASGHEAGQRAVWKDIIHDLIHPLLCVPDGKLNQYSCMLLQTVLQCSDNIISFAETVDASESMEAVLAACSEESEHDFCLQLVKLMLQSSVITSSLFDKLSISSQILLLHIAGACVSSESRQQHPEADNAISDSTLSCFAKKFKSTAHCILALAMKDRDEEDQNPQLVMSLLEVLCAASAETDLQPFLQDMDFVLETSLGLLDMVEQVGRSSDNAFSVRQDGAGTGDDASLAAEPGYGFKRNLVQLIGNMCFRHRGNQDRVRELKGIPTILQQCNIDSKNAFINQWAILAIRNLCENNLENQAFLLSLKSQGVADNEALGRLGYEAALREDGQIYLKNLKK
The following text describes a protein:
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Sequence:
MLLSTSCAVSAVSSRLDSGRAGRWPRAAAAAPSATGVRRGVLQTRRALSDSEGREPAREDPVIARAREQVQSGLVFQPMGEVQPLVAAMDQQLMDPKAEPGLAATYSLARSNYSPDLESGINEQINIELNMSYVYTSMYNFFARDDVGLPGFAAYFRHNSDDEREHAHLLMNYQTQRGGRVRLLALAPPETEFWHAEKGDALHATELALSLEKLNFQKLRDLHTVAQTVGDADATHFIEDYLLHEQSKDVKEAAVLVSQVRRAGRGHGVFHVDTLLAQEYGDKGAGGLDGNGAGPLAG
The following text describes a protein:
Function:
Peroxidase; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins. The first step in the biosynthesis of sterigmatocystin is the production of hexanoate by the fatty acid synthase (FAS) units stcJ and stcK. The polyketide backbone is assembled by the non-reducing polyketide synthase stcA by condensation of the starter hexanoyl-CoA and 7 malonyl-CoA extender units followed by cyclization and release of norsolorinic acid (By similarity). Norsolorinic acid is the first stable intermediate in the biosynthesis of sterigmatocystin and is converted into averantin (AVN) by the ketoreductase stcE which reduces the hexanoate ketone to an alcohol (Probable). Averantin is then oxidized into 5'-hydroxyaverantin (HAVN) by the cytochrome P450 monooxygenase stcF. 5'-hydroxyaverantin is further converted to 5'-oxyaverantin (OAVN) by the 5'-hydroxyaverantin dehydrogenase stcG. The next step is the conversion of OAVN into averufin (AVF) which is catalyzed by a yet to be identified enzyme. The cytochrome P450 monooxygenase stcB and the flavin-binding monooxygenase stcW are both required for the conversion of averufin to 1-hydroxyversicolorone. The esterase stcI probably catalyzes the formation of versiconal hemiacetal acetate from 1-hydroxyversicolorone. The oxydoreductase stcN then probably catalyzes the biosynthetic step from versiconal to versicolorin B (VERB). The next step is performed by the versicolorin B desaturase stcL to produce versicolorin A (VERA). The ketoreductase stcU and the cytochrome P450 monooxygenase stcS are involved in the conversion of versicolorin A to demethylsterigmatocystin. The Baeyer-Villiger oxidas stcQ and the reductase stcR might be involved in the biosynthetic step from versicolorin A to demethylsterigmatocystin. The final step in the biosynthesis of sterigmatocystin is the methylation of demethylsterigmatocystin catalyzed by the methyltransferase stcP.
Sequence:
MLLKSIQNIVCGLVPTFFLFGSAAAELDFEQWHPAGLGDLRCGCPAMNSLANHGFINHNGSNITVNEVIPLMQEVFHLSEELATIVTGLAVLSADDPASGIFNLDMLNRHNIFEHDASLTRKDFYLGGDGHTIDQPTLDEFLSYFDGKEWIDLNDAAAARYARVLDSREKNPSFLYQDQQLITSYGETIKYFRTMVDPRSNKTSAEFVRILFTEERLPVREGWQRPREEISGFSLASDVVQLALRTPEKFIGMPFDQRPFAEQAFDPLPWQRPPIWTPPNYPGFSKRHFSELVGRFAKKALPFRA
The following text describes a protein:
Function:
Zinc-dependent metalloproteinase. Proteolytically removes the C-terminal three residues of farnesylated proteins (By similarity).
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDVGGALDLYGCSVNVYNAILIFIWVLFLWETYINLRQLKVAKRVTESPEEIKCLMNDVDFDKSRRYAIDKMNFDIVSGFYNILSLSAVLYFQLIAWAWHKSQEHMLFVCSYAPRSFGTTEGSEILFSLLFTVYVALFQFFESLPWSYYRHFVIEERYGFNKQTIGFFIKDRLKSLAVGLVIGLPIISMLVWIIKAGGHYFYIYAYGFTFVVSFIIMFIYPEFIAPIFDRYEHFPDCELRKKIEELAASIEFPLKKLYVVEGSKRSSHSNAYFYGFGKNKRIVLFDTLIKGFKMPGVEADSSANADESSDETQNRGCGDDEEILATLAHELGHWKLKHMTFNLIIAQINIFFMFFAFGQLINVDQLFVDFGFPPSTAPILIRLIVVFQFIFMPYSSVLEFLMTMLSRKFEFQADAFAVSLKSGEKLKSALLVLTKDNLSFPVYDWLYSMCNHSHPPIIERLAAIDAKMGKEK
The following text describes a protein:
Function:
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis-aconitate, isocitrate, and citrate at lower velocities and affinities.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLAFPRLFIVARRME