lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis. Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol. First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by SRD5A3. It then catalyzes the NADPH-dependent reduction of dolichal into dolichol. May also acts as a positive regulator of starvation-induced autophagy.
Subcellular Localization:
Lipid droplet. Secreted.
Sequence:
MRAVHCMASRGVFQDADCGGICKTGFRCDAQSTLGGCGCEQVPVVGDGRRLGMNEPRKEVAGRCPHLTQLLSRIFFFKRWKRFVAEMNVEFLYCDLASMQSIRQFVQKFQRKRIPLHVLVNNAGVMMVPQRKTVDGFEEHLGLNYLGHFLLTNLLLDTLRDSGCPGRSARVVTVSSATHYVGELNLADLQGSRSYSPHGAYAQSKLALVLFTYHLQGLLAAQGSPVTANVADPGVVDTDLYKHVFWPTRLVKKLFGRWFFKTPEEGAWTSVYAAVAPALEGVGGRYLYNEKETRSLAVTYDLKLQRQLWARSCQMTGIPDGTGGVFPASLPRREE
The following text describes a protein:
Function:
Probably functions as a GTPase-activating protein (GAP) for RAC1 and/or CDC42. Required for optic stalk formation.
Sequence:
MSDKVSTSLAAQLHSHALASAEAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAISAQLNFKIVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSSARTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQGTFTQPGQKQESSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTPARSPRYSLLLCDTESSDNSSAVNTPQYDMEPLMLTSAMSGVSGVSSNVQQQQLLLGVDASSSYLGSSHESLGQNINNHHDAEQRDMNALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPVYEDFEQTPVKMVPSPIKSTISITYKSPEKEKKPSAILETNFDENTVYEQVKLFRNSVTEVNQMLHERSSLKQIAEEEQHDGGAYKAAEMTQQLLQLEQEHHDHEEQQEKEPEDEEQSQLLYENIELRKPKTVYENLRGEEMKFITEEQKPNVDRIELDSLDSLPDNMEHEQSSPSKSPTFSVKELANKFESSPVEQLPNFDFSVRGGSMKKPNELSVPKTMPAPVPLKKLNSSAQKITRSLDENAFVREFGGKQLQDLSLSNKLPEVMSEVNSRRKSFDFTRPKTLNPPKRLPGMSITEEICQKRVGEMEAITPTTENRISLIQQNNMPKEQQSSANQFLPPAGRKNVLTGVVLDRERIDKIKEERRQQLTQKYYGDTLKSRSRTELNSEDNFPAAESLRIKSKSRGDMHALQKDIDMNLKQLSRVTGGGSECTLHTGLSQGNGQEHLGQQRVRRISDEKNQNCDTSNGGVSGITSTSLLSVKTTAQKYGSTSKTPANKFERSQPMPRDRLQRNSLAESNAGTNNREKISPQFSIRDVTAMFESRSQNQ
The following text describes a protein:
Function:
Involved in the modification of secondary bile acids into iso-bile acids (3beta-bile acids) via epimerization of the 3-OH group through a 3-oxo-intermediate. Catalyzes the reduction of 12-alpha-hydroxy-3-oxo-5-beta-cholan-24-oate (3-oxo-DCA) and 3-oxo-5-beta-cholan-24-oate (3-oxo-LCA) to yield isodeoxycholate (isoDCA) and isolithocholate (isoLCA), respectively. Is also able to catalyze the reduction of 3-dehydrocholate (3-oxo-CA or 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate) and 7-alpha-hydroxy-3-oxo-5-beta-cholan-24-oate (3-oxo-CDCA), into isocholate (isoCA) and isochenodeoxycholate (isoCDCA), respectively. Accepts both NADH and NADPH as cosubstrates. The conversion of the abundant bile acid deoxycholate (DCA) into isoDCA by the gut bacterium E.lenta favors the growth of the keystone commensal genus Bacteroides, since isoDCA is less cytotoxic than its parent compound, DCA; iso-bile acids have thus a potential role in modulating gut community composition.
Sequence:
MSEARHNPVLAGQTAVITGGASGIGKSIVQRFLEAGASCLAADLNEEALAALKQELAEYGDKLDVVKVDVSNRDDVEGMVDRAVQTFGQMDIIVNNAGIMDNLLPIAEMDDDVWERLMKVNLNSVMYGTRKAVRYFMERGEGGVIINTASLSGLCAGRGGCAYTASKFAVVGLTKNVAFMYADTGIRCNAICPGNTQTNIGVGMRQPSERGMAKATTGYAGATRSGTPEEISAAAAFLASDQAGFINGETLTIDGGWSAY
The following text describes a protein:
Function:
This protein is responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Subcellular Localization:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Cell membrane; Single-pass type II membrane protein. Cell projection, filopodium. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Sequence:
PGATLQXAXXLLVAVXAXPPPPLGVXPKPXPG
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MKVTIGGQHKPMFLIYFKGTLGKTFPISNAKHIALSDESCGRWIAYSDEKDPILRPSDCYKRRWLEGRQKNACKKNFDMVESIKIGARQSIDQCQKQFVGRRWNCSVVKKGNVFGKILNFGTRESAFVHALSAAGLAYSVTKTCSSGQLDRCGCDNSNHRKFDHQLQSVVRRTQYNRQQHQRFKHPHSQQQQQQHHQLQQQQQLRPHTQQQPQLHQQQNYQKRVVDIQWSGCSDNADFGTAISRLFVNGRENITGRNPMRALINLHNNNAGLKVN
The following text describes a protein:
Function:
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MSGGRFDFDDGGAYCGGWEGGKAHGHGICTGPKGQGEYSGSWNYGFEVVGVYTWPSGNTYEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQNVSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGIAAVVRNPLRTSLTSLRSEHSNGTLLQHDSPTANLENLPMTPTITRGGFALSLYADADAAKLKKGGLFRRSSLFGKLKKADSKTSLTSQRSRLSFLKSESGMSSTGSDATSTASLGEGAEGEDFAPFDADIDATTTESYMGEWKNDKRSGFGVSERSSGLKYEGEWLDNVRHGYGCTTLPDGKKEEGKYRMNVLIKGMKKRVIPLKSAKIRQKVDRSVEGAQRAAAIARQKSEIAASRTAHAKAKSEGAEQAALAANNESTLARSMARELSPDFYQPGPEYLKRRLFQELLENEENLEEEAPPMEEPLPPASPEGPQVDKQDSTKSKESTAQTPSPHGTPPQAKRVKQGSQKESFRSPGSWNGDHGKERSHTGSRPNTPSNALSAPVEKSASDLRPASQSPSRHGHTKSPTEQMEIKPLQRIHQGGDVELIKGYHSYAVRTSPVTPPIDYEEESFPDSKLPVEPVSPEPKADVKATEQKMEPQKREDTPVSHHEPAHEEKKAHKAEPKHEPRQLPPPEHKVEEKAEAATEGKPEQKTETKVVAKVEPKAVMKKVPPPEAATKEVEEHEEVMLCGQHSRGRKERGLSLSVLKKGLGWEMQAEGNLPVLIIPFLMFQLFFCSHFSEVFFM
The following text describes a protein:
Function:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Sequence:
MFALTFLGTSASVPSAERNHPALLVEAAGKRILIDCGEGTQRQLLRSGAGFRRLDRILLTHAHLDHVLGIPGLFSTLGLRQSSDVMTIHGGPGTLDIVIRMLAGLWGAGRAPIPVEFAALSEGQVIDAGGFTIDCFPVRHRDTDSFGFVFQSPARRHLLPDRLASLGVPDGPLRGELAQGRPVVIEDGRTIDPEDVLGPATGGRKLVVIGDTETTEGLSQYVADADMLVIEATFLDRDASIARDYGHLTAAEAAAFAAANNVGQLVLTHMSGRYEDEEILAEAARIFPNSRIAADFDHIVV
The following text describes a protein:
Function:
Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities.
Miscellaneous:
MISCELLANEOUS: Present with 2360 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MTERIPIKNYQRTNAKALLKLTEKLFNKNFFDLYLTSQQLVVLEYLLSISSEEDKLKAWDYFLKGNIALNVEKSFPLTQEEEHHGAVSPAVDTRSDDVSSQTIKDNNNTNTNTSISNENHVENEIEDKGDNAIANEDNFVNNDESDNVEEDLFKLDLEDLKQQISGTRFIGNLSLKIRYVLWQCAIDYIYCDRNEFGDENDTEYTLLDVEEKEEEEIGKNEKPQNKEGISKFAEDEDYDDEDENYDEDSTDVKNVDDPPKNLDSISSSNIEIDDERRLVLNISISKETLSKLKTNNVEEIMGNWNKIYHSFEYDKETMIKRLKLEESDKMIEKGKKKRSRSDLEAATDEQDRENTNDEPDTNQKLPTPEGSTFSDTGNKRPKQSNLDLTVNLGIENLSLKHLLSSIQQKKSQLGISDYELKHLIMDVRKNRSKWTSDERIGQEELYEACEKVVLELRNYTEHSTPFLNKVSKREAPNYHQIIKKSMDLNTVLKKLKSFQYDSKQEFVDDIMLIWKNCLTYNSDPSHFLRGHAIAMQKKSLQLIRMIPNITIRNRADLEKEIEDMEKDKDYELDEEEEVAGSGRKGLNMGAHMLAKENGKVSEKDSSKTVKDEAPTNDDKLTSVIPEGEKEKDKTASSTVTVHENVNKNEIKENGKNEEQDMVEESSKTEDSSKDADAAKKDTEDGLQDKTAENKEAGENNEEEEDDDDEDEDEDMVDSQSYLLEKDDDRDDLEISVWKTVTAKVRAEICLKRTEYFKNGKLNSDSEAFLKNPQRMKRFDQLFLEYKEQKALESYRQKIEQNSIMKNGFGTVLKQEDDDQLQFHNDHSLNGNEAFEKQPNDIELDDTRFLQEYDISNAIPDIVYEGVNTKTLDKMEDASVDRMLQNGINKQSRFLANKDLGLTPKMNQNITLIQQIRHICHKISLIRMLQSPLSAQNSRSNPNAFLNNHIYNYTIIDDSLDIDPVSQLPTHDYKNNRELIWKFMHKNISKVAMANGFETAHPSAINMLTEIAGDYLSNLIKTLKLHHETNSLNRGTNVEMLQTTLLENGINRPDDLFSYVESEFGKKTKKLQDIKQKLESFLRALLRPTLQELSERNFEDESQSFFTGDFASELTGEDFFGFRELGLEKEFGVLSSSVPLQLLTTQFQTVDGETKVQAKKIQPEESDSIVYKKITKGMLDAGSFWNTLLPLLQKDYERSKAYIAKQSKSSANDKTSMTSTEDNSFALLEEDQFVSKKTATKARLPPTGKISTTYKKKPIASAFILPEEDLENDVKADPTTTVNAKVGAENDGDSSLFLRTPQPLDPLDMDDAFDDTNMGSNSSFSLSLPRLNQ
The following text describes a protein:
Function:
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation.
Subcellular Localization:
Postsynaptic density. Presynapse. Postsynapse. Cytoplasm, cytosol. Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons.
Sequence:
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKASQAHVRIGDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVSVQKGEPKEVVKPVPITSPAVSKVTSTTNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHAATSSHASPTPVAAATPLHLSASGLHVSANLSADQCSSPPNTGKPAVNVPRQPTVTSVCSESAQELAEGQRRGSQGDIKQQNGPPRKHIVERNTEFYHIPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLTESENDNTKKANSTQEPSQQPASSGASPLSASEGPESPGSSRPSVAGLRSAAAFKPVGSTSVKSPSWQRPNQAAPSTGRISNNARSSGTGASVGPPQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICRGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MTEGAMMKENILQEKMDIVSEMITMLAAGEQAEELERVTEVWAKTNQLREKQEEDVKKTIQALLAMNEDEEQNVKSISQSEGGIQQKEAELEAEKCQAEKQRQQTEQGVQSLMGKLEKLKEEKEAVGKQKESVTQNTTEALPDVRYLATLYTNVTKLKWDFSCGPDEIKGFVTCKSDVKPFSLNSKQNSQFFVANYLWDLMDETFD
The following text describes a protein:
Function:
Polymerase that creates the 3'-poly(A) tail of mRNA's.
Subcellular Localization:
Nucleus.
Sequence:
MWNSEPTHRQHHQHNGNSTSGGPPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFLVFSRWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTKKVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVESKVRLLISNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSMWFIGLEFERSENLNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYLDSDFLKRERKSMESHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEENSNASSDMGAGTPTTPTTAQLSAPSFKSSGKNGSEIDVVEQEPTQPHNNGNASSNTTTTEVACS
The following text describes a protein:
Function:
Could have a critical role in early developmental decisions in the sea urchin embryo.
Subcellular Localization:
Secreted.
Sequence:
MDVSKVLILTLIWLLTADSAPPDYVTLTRKMESKILRVMGLSERPRPKPNATAPQYMWDLYRQQMAATEGAAASRGGETEIGKEEEEDGRPCSETKLSSNIIRSVSHTGGDLRASNSTSLQQILLFDVASIPHAETIEAADLRLEIPALPSATDVPSLAVRIYQLESRTRLNSIVSLKDKRLRLLDVVLADLSQGYAGTIDILSTVNSWRSKKTSNHGLLLHVELMSTSGNNRRGSQVIKELGAISKKCTANLIVTSSEYRQCSKRNRRNKRQAESEAPADISSFPTASLTNLCQRHRLFVSFRDVGWENWIIAPMGYQAYYCDGECPFPLGERLNGTNHAIIQTLVNSIDNRAVPKVCCAPTKLSGISMLYFDNNENVVLRQYEDMVVEACGCR
The following text describes a protein:
Function:
May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MNLNKNNNSVEDSVSSDLIDLECTFESMGLDNRILRALKKMGFQNPSLVQSKSIPLSLQGKDILAKARTGSGKTAAYSIPIIQKVLMAKEKSNIKGVKAVVLVPTRELCEQVKNHFNQVSYYCQQLVSVVQLGNDKTLDEQKGLLRDIPDVIVSTPTRLVQHLENKTIQLQSTLDILVIDEADLVLNYGHQNDINIIKSFLPKVCQCFLMSATLTKEVEELKKLVLHTPAVLKLEEDKAIQTNLSEYSIKCAEVDKFLLVFSLLRLRLMQGKILFFVNDTNNCYKLKLFFERFHIKCAVLNSELPINSRHDIILQFNKGLFDYLIATDESFKSDSNKKEEQELEDNENEDDDDDDDEMTDVKKEDDEENEDEEENDEENEEDEENEEDEEDEENEEDDDEEENEEDDDKKNKNKKINNSKGDKEYGVARGIDFRNVDIVVNFDFPRTIKNYIHRIGRTARGTNKGIALSFVTYHNEELLKKVSKTRGDAGYNLKPFEFKMNAIEGFRYRVEDVLRTIGIRAIKEAKKTELKQELLNNEKLKSHFSENPQDLLALKHDTTLIKKQVPLHLRVVPEYLLPTQFKNHADQKLEIIPSRPQSGHHGTTGRSLGVNKKLEQKKRKKDILKTLSIKKNTTLTGEELAQARSKSLIKRLKIKEGNISADGSYKTVKVQKKGANNNRRKLIVD
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MALNPQTPSKHNQMITRFIKHPKSTNFDGDKDRPAKRQKTGNSPRKQPPHTPRKFANREILDSDVEDDGRDVKTEEKEEDVHKTDLESALPQVKVDDEAIEAYEAFKASQEDNADVAGERIEKRAWVRGKSSLYVDAFNLALDTVLEDESHLFDEAETDVFRIWREMSYEAQFLYVRLFLRKTSAWHRVKNLGYHSDISDLEGAAQILQQTHILPTSSAEVESHPGELEAPTGATLGTSFTFADRSEEEITTLEEASSLLKLDELKLLARDAKVQGKNKKDLLKALRRTSRKQTGLGHVGLKRSDSEMSRRSSASAPGSRHETPEVEPSPVDDLSDDANRDAHFTRKIMNETGPCIRLSLPTLKLFERVHLVFYRSTEWTEKSLTTIILAKIARWNFPEYIVSRSANIFASRSLLLEYEASVRTQFRIDNILEFNGRPTEKDFDEIMDTFEQVHSRWQALCQEEQRKEDSIYHSGEGSYLRRLSPAWVYTRIIHKALYVLGRRKEHKREHALLTELLGQRLFHHSRRGAWYQRKALLEEHYMASLNEAEKRSEDQQKKHWKRIALQTCQDGLQDRFVHIIHHYDLQKRITKLEKSLNIPKRSQHDFGHVRLTKPAEVTMEGIRIERDRPVLSRRNSSPHPNPSRRGGKTIWIDPREDGECSVEAMCLSHYRNQGWKGYHSEGGIVRTLFAYLFFDVLFTYIPNVFQTPYQTCPLDLHTDAFYPSRISEINARLNEISNGDAPSIMRRIYDDHHERRTCVVGLDWSFDINDLIEIAQCFDGEALATVCKVMAQEYGQRGGGVPDLFLWKVADEEGAKGEVKFAEVKSENDRLSDTQRLWIHVLSGAGVKVELCAAVAKEVRVVS
The following text describes a protein:
Function:
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
Subcellular Localization:
Cytoplasm.
Sequence:
MADETELKRLYWHSRRGMLELDVLLVPFVQEVYPGLDAEDQARFRKLLECEDQDMFGWFMQRGEPEDADLRRMVRMILDRVQPD
The following text describes a protein:
Function:
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton. Note=Associates to cortical microtubules (MTs). Recruits calmodulin (CaM2) to microtubules.
Sequence:
MGRSPASSCLRLISCSGGDDTSADPNSTALENKSSGDKRGWSFRKKSGKQRGLITSVVSETTPASRTRETLESALLKSPSPDNNNVSEKQQQSFSVDEKKSQLPVVTYVAEPVDEKKTQSVIEEKTELLSVEEQIDHRTEVSPVIVESKGTETEEDDLIGTELQGPSAADAAKIEEDVTSEVEMASKVEPEESESDDVIIVRKESDEKVDEKLDESVIVVIQAAVRGFLARRELLRSKKVIKLQAAVRGHLVRSQAMGSLRCVQAIVKMQAMVRARHSTKDGSRVSATSDKSEPNAAAQKLLENKFAKHLMESTPKTKPINIKCDPTKPSSAWNWLERWMSVPKPEKTSKANLTTEEQNLEETQNVKISPQADFVNSDSTVENKTETDMPSYEASKVEGQNVELSETEKMSQYDSPEASAEVYYDSIQSQPLAAKPDSLLEEPEYVDGQIKHSLKRKVSNPSFIAAQSKFEELTSSTGSNKAMTLSSKDDVLGEEGKTDIDSPDTTNTIKDHSLEDVTPAELSGSECGTELSVTSSLDTLEKKSDAEGAEPRVEAKLLEDDTFKTDQAELIEIDVKDATSMGTVEDPKEKVENAKDEVEISATHHEPVISTPDSKKRRAEDESGPQAYALSEGALTPMTITESQATPASQASSSVKARKGKSEKSGSSQKRKVSKKITSSPKQEIGTGEATEQEEGKEQKSGRRTSFGYDQEARESSGGKNSLPRFMQPTQSAKAKVQEHNSPRSSPDLQERDVVSAKKRHSLPGVTNGKQVSPRIQRSASQAQQGTKDRKWQR
The following text describes a protein:
Function:
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MASVGLEKVNILGRDSIHVGYDLRAHIARTVFESCVSSTYVVVSDANVARVPYHEALCAALEEGLPARSRMLRYVVQPGETYKTRETKGEIEDFMLAEGCTRDTVVLAVGGGVIGDMVGFVAATFMRGVRFVQVPTSLLAMVDSSIGGKTAVDTPAGKNFIGSFWQPEFVFVDVKWLETLPRREFINGMAEVIKTACIWNAAEFMRLEMHASMFLQVVNSSKQVKVDTKGGPTSLSYTNITQILDHVFQLVLESIKVKAHVVSSDERESGLRNLLNFGHSIGHAYEALLTPQALHGECVSIGMVKEAELSRYLNILSPTQVARLTKVLSAYGLPTSVNEGWFRELTLGKRTPLEVLLRKMSIDKKNDGSNKKVVLLETIGKCYGTSAHVVSDTDLRFVLTDEALVYPFTDVRSSTGHTIVPPGSKSISNRALILAALGKGKCRIRNLLHSDDTKHMLEAVQQLNAATISWEDNGDTVVIDGHGGRTLTASDLPLYLGNAGTASRFLASVASLVCPEGNRDSVILTGNARMQERPIGPLVESLRLNGVRVDYLNREGSLPIKVHAESKFRGGRINLEASISSQYVSSILMCAPYAEEPVTLSLDGKPISELYIEMTIRMMEKFGIKVEKSNDELYTYHIPRGQYVNPAEYVIESDASSATYPLAFAALTGTTVTIPNIGHDSLQGDSRFACDVLKPMGCTVQQTATSTTVTGPEPGTLKPLEHVDMEPMTDAFLTACVVAAAAHSPESKCKNIITITGIANQRVKECNRILAMVTQLSKFGVTAEELPDGIQVHGVEQLSQLKVPDAVETYDDHRVAMSFSLLAGMVNYGQAPSSCRPIKILERRCTGKTWPGWWDVLHSRLGATLDGNEPLPEKENDIRKSVVLIGMRAAGKSTVGRWCAEALGYKLLDLDDEFQTYFGMGTVKEFVAQNGWESFRSKETDLFGHVLNKYSRSGYVISTGGGIVETASSRKLLQDFAATGGVVLHLYRDIDETIKFLRTDPTRPAYIEEVRGVWDRREKWYHLCSSYSFFSPHCSTTAEFEGLRRVFSKFIRRITGMLPVEVPVKRSTFVCLTFQNLLPEMERIKEAVYGCEAVEVRVDHLENYSQDFVLKQLTALRLATDSLPIVFTIRTKKQGGKFLDNDYSTLEDLLTVGLKAGVEFLDLELTLPSPIHQRILNKRYKTRIIGSHHDFSGEFSWEHPEWEHRYAQALAMQVDAIKFVATAKGFGDNLSLEEFRSKHTDKPLIAINMRECGKLSRVLNTILTPITSDVLPQAAAPGQLTLRQINELYASIGGLRPKKMFVVGSPIGHSRSPILHNTGYNSLGLPYTFDKFETDSAEIVKKSLLSREDLGGIAVTIPLKQDIMQYLDELTDSAKCIGAVNTIIPKKDGRFIGHNTDWLGIKNSLIANGVPEHVNTAGLIVGSGGTARAAAYAFHEMQCSTIYMINRTTSNLTELQKSFPQEFNIHVIESLEQIEQLSEPVGIAVSCVPSDKPLDDALSQKLSAFLSRPSATNFIPTILDAAYKPLVTPVLKLASEVHGWRPVSGAQMLVHQGVAQFEIWTGFKAPFAPVYDAVTQE
The following text describes a protein:
Function:
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
Domain:
Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
Sequence:
MPANLSSALETFKQQRDAAEAHYLKANRVSVFFREYTAAVETLLAALWAEYFQNSALCLMAVGGFGRGELYPCSDVDLAVVSPAPLSDGIQEQIARFVQTLWDCKLMPSVKSGSVDELCESVRNDITGDTAFLEARFLFGNRQTVDKLAEKMNAQRNVAAFVEAKLVEMEHRHAKSQGSGAVLEPNIKSCPGGLRDIHTLLWIAKAQGLATDLPDLLKQRILTRAEAGMLSHGYRRLAHIRIHLHLNAKRAEDRLLFDLQPQVAESMGYEGLNLRRQSEELMRVFYRAIKTVKQLGGILTPMLQSRVSSTPLRVTLRIDDDYIQVNNQIAARHTDIFFRRPEHIFKIVEIMQQRNDITALEPQTLRAWWGATRKINRSFYQNPENRRRFAGFFRNGNGLTQTLRFLNLYGVLGRYLPAWEKIIGLLQHDLFHIYPVDDHILTVVRNVRRLALDMHSHELPYASALMQSFEKQDILYLAAFFHDIAKGRGGDHAIQGIADARQFAADHFLTGEESDLLAWLVENHLLMSAVAQKEDIQDPSVLDAFCKRVQTHERLSALYLLTISDIRGTNPKLWNAWRASLLESLFHAAGRYLTGNGGNPHTLFGRRRQEAADLLTRAAVPEKQQKKLWNALGSAYFARHQSREILWHAANLVHDFETPIVRSRILPKSDSFQVMVFMPNGPRLFARLCRIFSRHGFDILAARAFITEHDYILDTFIVQIPSQHAPEDYPDIQSALEAELNSFIHGHTVAETQSRSRRISRRSRYMPIAPSITITPEEDYPDWYSVEITAVNRPFLLADMAEVFFAHNVSLRYAKISTLDERAEDSFTVFSPDLKNPKIQSSLKQTLLEQLS
The following text describes a protein:
Function:
Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage. Interaction with rad4 via its phosphorylation sites in the N-terminus couples the DNA checkpoint apparatus to chromatin via interaction of its C-terminal BRCT domains with epigenetic modifications on histones H4 and H2A, respectively, in the G1/S phase of the cell cycle, and facilitates recruitment of the checkpoint kinase chk1.
Subcellular Localization:
Nucleus. Note=Recruited to sites of DNA damage, such as double stand breaks.
Domain:
The Tudor-like region mediates binding to H4K20me2.
Sequence:
MEVNDTSLHKGFGLDINSQRVFGAQAAISRNNYSKVNASINPSPPRSNDNSNKEFSYSKDVNNNGAVEELSLTQLFEVPSQAAFAKQSSQDISDDELIQHDSRKVISSPYSPKQTHTVLKRLYDRQSVISDHEKLLTPQNVSNSSQILSPFTSLLPSTLSTLKDTPLSVSQNEKNLETVGEVLVPETVAQHRTKFYDYTLDEMENETESGQVETTPTRLATSLGSPVLYGRVESTPPAFLPETSEKQYKRKFSFTEPSSEKVDNTETKFSKKTKNINDENFPNPFNVISSYETSASPSTVIDQSSQVSSIFVNKRLRKSVNNQAISRSDSLSLDTPKIDSLFTRASIKPLKPSQSPNSRRSFKNRVLAFFKGYPSFYYPATLVAPVHSAVTSSIMYKVQFDDATMSTVNSNQIKRFFLKKGDVVQSTRLGKIKHTVVKTFRSTNEQLSLIAVDALNNDMVILAHGEIEVTVPISTIYVAPVNIRRFQGRDLSFSTLKDMKFEETSFLPSHDSQRNRSSLKERDSSFVKKNLDSESNQLIFDDCVFAFSGPVHEDAYDRSALETVVQDHGGLVLDTGLRPLFNDPFKSKQKKLRHLKPQKRSKSWNQAFVVSDTFSRKVKYLEALAFNIPCVHPQFIKQCLKMNRVVDFSPYLLASGYSHRLDCTLSQRIEPFDTTDSLYDRLLARKGPLFGKKILFIIPEAKSWQKKIENTEQGQKALAHVYHALALGADVEIRPNVAHLECDLILTMDGNIVDETNCPVVDPEWIVECLISQSDIST
The following text describes a protein:
Function:
Involved in translation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSFLYSHPPGASQVGTTVTLARDRHRPKPLVSDLVLTCDFPDSERGAQTSADSARQNLVHQICMFHHLVPTSIIGCLDLQTHAMFKKFSHENINSKANVKSSSQRALKAKLVAQFPDMEPVVDQIIPKKAQLVHVKCQDRISLYTIDGKVMFFQHFDDELVPSLHLVHQFPQYFPSIKTDRGAIKFVLSGANIMCRGLTSKGAELPDEPMEKDQIVIVNAEGKEHALAVGKLTMSTKEIEEVNNGIGVELLHYLGDGLWSHHE
The following text describes a protein:
Function:
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes; Regulates also the sphingolipid metabolism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MREHDQFDPSIIRLGILLLLFDVYLTWARIEKQTTAPVSAPIETDNTNFLRLAKQPIVFQYIFFLLLCALSTLSFHLSIRFLTSSPFSPLVFLGLLPKYTRPNSVSTALLVSSSTKLFPILMVIWEYDVPAAARSLGWAVVANNVEALKILLDCGYGTAAILATVGAISRWMVGRGILWAVGLDGVDTVGDSGVAADGKALWAIVELGREWGGRLGLG
The following text describes a protein:
Function:
Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MDATNGNGGASKYITLVSKDGFEFVVLREATLCSDYIRGMLRNNMTEARTGRCELQDINGVILEKVVEYFHYWYKYRDREDVPDMEIPVENCLELVVAADYLGMDSKPH