lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane; Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Miscellaneous:
MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage. Is probably proteolytically processed to yield IL-16; MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. Is proteolytically processed to yield IL-16.
Subcellular Localization:
Secreted; [Isoform 1]: Cytoplasm. Note=Colocalizes with GRIN2C in neuronal cell bodies and neurites; [Isoform 2]: Cytoplasm. Nucleus.
Sequence:
MEPHGHSGKSRKSTKFRSISRSLILCNAKTSDDGSSPDEKYPDPFETSLCQGKEGFFHSSMQLADTFEAGLSNIPDLALASDSAQLAAAGSDRGKHCRKMFFMKESSSTSSKEKSGKPEAQSSSFLFPKACHQRTRSNSTSVNPYSAGEIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDYPILGTARPTRSLSTAQLGQLSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDSSPFSLESPASPASTAKPNYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEINDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVEGVKFGKDRHQWSLEGVKRLESSWHGRPTLEKEREKHSAPPHRRAQKIMVRSSSDSSYMSGSPGGSPCSAGAEPQPSEREGSTHSPSLSPGEEQEPCPGVPSRPQQESPPLPESLERESHPPLRLKKSFEILVRKPTSSKPKPPPRKYFKNDSEPQKKLEEKEKVTDPSGHTLPTCSQETRELLPLLLQEDTAGRAPCTAACCPGPAASTQTSSSTEGESRRSASPETPASPGKHPLLKRQARMDYSFDITAEDPWVRISDCIKNLFSPIMSENHSHTPLQPNTSLGEEDGTQGCPEGGLSKMDAANGAPRVYKSADGSTVKKGPPVAPKPAWFRQSLKGLRNRAPDPRRPPEVASAIQPTPVSRDPPGPQPQASSSIRQRISSFENFGSSQLPDRGVQRLSLQPSSGETTKFPGKQDGGRFSGLLGQGATVTAKHRQTEVESMSTTFPNSSEVRDPGLPESPPPGQRPSTKALSPDPLLRLLTTQSEDTQGPGLKMPSQRARSFPLTRTQSCETKLLDEKASKLYSISSQLSSAVMKSLLCLPSSVSCGQITCIPKERVSPKSPCNNSSAAEGFGEAMASDTGFSLNLSELREYSEGLTEPGETEDRNHCSSQAGQSVISLLSAEELEKLIEEVRVLDEATLKQLDSIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGATHNDALAILRQARDPRQAVIVTRRTTVEATHDLNSSTDSAASASAASDISVESKEATVCTVTLEKTSAGLGFSLEGGKGSLHGDKPLTINRIFKGTEQGEMVQPGDEILQLAGTAVQGLTRFEAWNVIKALPDGPVTIVIRRTSLQCKQTTASADS
The following text describes a protein:
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular Localization:
Nucleus.
Sequence:
MFVDHLNKSPGRKSSSSSSSLSSSSYSGNPTNSKANVGFEMRQAKKYSGILSGGIPKRHGPHLLPLARIKKIMKKSSVDVKMISGEAPLVFSKACELFIEELTKRSWNMTIQGKRRTIHKEDVASAVATTDVFDFLIDLVRPNTSNHVDLNEDLEKTQ
The following text describes a protein:
Function:
Small heat shock protein required for the establishment of auxin gradients and for patterning of the apical domain of the embryo. Involved in the specification of the cotyledon primordia. Also required for normal inflorescence and floral meristem function, normal developmental patterning and thermotolerance. Acts as a molecular chaperone.
Subcellular Localization:
Cytoplasmic granule.
Sequence:
MQEEKPSLPFNASFDPSNPLGLLDKVLDFIGKESYFLLKDTADKEIASAVTAAKKRLREAEEEEESLTPLEKKLKGKSPTEPIEVEKLRKEGLEPTEPIEVEKLKKESLKPTEPIEVEKPKEREFTFGAIPNKWNVTLGEVPNKGNGLDFEKYSWTQDHEEVTITIPVPSGTNPRYVTCEFNTYRLKVCLQGGQHTIIDGALFGAVNPNDCFWYLEDEKVIWVLLRKQDRCGWWKYCMKGEPEIDTQKVDRKSSKLDDLDPDTRSKVEKMMFDERQKHDLKKKSTSQNHSLRMQGEPWFWRNLTNKRK
The following text describes a protein:
Function:
Deacetylase involved in the biosynthesis of neomycin by mediating 2 steps of the pathway. Deacetylates both 2'-N-acetylparomamine and 2'''-acetyl-6'''-hydroxyneomycin C.
Sequence:
MGEPTWEAAEDPDRTLRERLRRGRTLLVSPHPDDVAYSCGGLLAAVGRPAHATLLTVFTRSAWALPRRLRRAGARVVSERRREEELRYCRLRGLAEYRPLGFADAGLRGYDDETELSSPAEADGVRGAVEEAVAEAIRDAGADTVLAPAAVGGHVDHLLVHGAVRGAVGPGGPLTLFYEDLPYAGQRDAVDVERTLREARGLVPFASVDISGVVQQKVRGMYVYGSQTDDECVRETLRHARRGAPRRWTGGTAGAGHAAGRRGAPHTERVWTPAPAGAR
The following text describes a protein:
Function:
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.
Subcellular Localization:
Cytoplasm.
Sequence:
MSPCSRVALVTGGNKGIGFEIIRDLCQKFSGDVVLTARDEARGCAAVQKLQAEGLNPRFHQLDIDDPQSIHALRDFLLKEYKGLDVLVNNAGIAFKVDDPTPFHIKGEVTMKTNFFGTRDVCKEMLPLIKPQGRVVNVSSMVSLSALKDCSPELQQKFRSETITEEELVGLMNKYVEDAKKGVYVKEDWPNSAYEVSKIGVTVLSRILARKLNEQRRGDKILLNACCPGWVRTDMTGPQATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKTVEPW
The following text describes a protein:
Function:
Catalyzes the biosynthesis of agmatine from arginine.
Sequence:
MQEVHDYGIKFWSNNEFKIEKGLVKVCHGKNPSLLEIVQSVRDKGYRGPLLVRFPHLVQKQIKSLFDAFSSAIKEYQYSGAFKAVFPLKVNQMPSFVFPLVQGAKGLNYGLEAGSKSELIIAMSYTNPKAPITVNGFKDKEMIELGFIAKSMQHEITLTIEGLNELKTIIAVAKQNEFLACPKIGIRIRLHSTGTGVWAKSGGINSKFGLSSTEVLEAMRLLEENDLLEHFHMIHFHIGSQISDISPLKKALREAGNLYAELRKMGAKNLNSVNIGGGLAVEYTQHKHHQDKNYTLEEFSADVVFLLREIVKNKQEIEPDIFIESGRYISANHAVLVAPVLELFSHEYNEKSLKIKENNNPPLIDEMLDLLANINEKNAIEYLHDSFDHTESLFTLFDLGYIDLIDRSNTEVLAHLIVKKAVQLLYVKDHNDILRIQEQVQERYLLNCSFFQSLPDYWGLRQNFPVMPLNKLDEKPTRSASLWDITCDSDGEIAFDSTKPLFLHDIDIDEEEYFLAFFLVGAYQEVLGMKHNLFTHPTEFSVVFDEKGDYEVEDICEAQTILDVLDDLDYDTKEIERLLKQKIEDNNQLDMEEKKEIMGRLYVMLSENGYLRTIS
The following text describes a protein:
Function:
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MLYYPHIDPVAFRLGPLKVHWYGLMYLVGFAMAWGLALYRARDPKRHWTAQQVGDLIFYGALGLIIGGRLGYMLFYDFSNFIANPLTLFQVWRGGMSFHGGLIGVIVTTWIFSRRTHKRWMDVTDFVVPLVPLGLAAGRIGNFINGELWGRVTTVPWGMVFPNAGPLPRHPSQLYEFLLEGVLLFIVIWWFSAKLRPRFAVSSLFLLCYGLFRFTAEFFRQPDPQLGFVAFGWLTRGQELSLPMIIIGGFALWWAYRHKER
The following text describes a protein:
Function:
Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Sequence:
MASTKRNTIRVGILTVSDTCSRKEAVDKSGPNLKKLAEDTDGLDGVIVATGIVPDEISNIKETLLEWSDVKELDLILTTGGTGFADRDVTPEATKSVLEKEAPGLAMVMLMGSLKITPLAVLSRSVCGIRKRTLIVNLPGSLKGSQECFGFVQPSLSHAIQLLKGERACVKATHKELAASGPQPGPLPGPQPINMVSNLPTVSHGHHNCQKIRHHDVEKVARRPRDSIYPVIPLKDALKIVMDHTPVLQPEVVDINDALARIVAEEIKAPISLPPFRNSIKDGYAVLASDGPGVRQVMSDAIAGDAPDLELIPGHVIRITTGAPIPKGADAVVQVEDTELVEEADDGRREVSIKILSTPTTGQDIRPIGSDLQEGTMLVGPGSKLSPPELGLLASVGITKIKCYRRPVVGVCSTGNELTEPSEELPPGHIYDSNRITMLATLLEMNVPTVDVGITPDTVQATKDVLLKAASQSDVIVTTGGVSMGEKDLLKYVLSEELKATLHFGRIFIKPGKPTTFCTFEYEGAKKLFFSLPGNPVSGIVTFNHFVLPCLRRMMGYTNPHLKRIKCRVMADLKLDPRPEFQRAHLDWQSAEDGVPLASTTGNQISSRLISMLQANALLALPSQSDQQKMIPKGSLVEAVVLRL
The following text describes a protein:
Function:
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity; Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDYKIKNKKRERSSDDDDENSSGNEKIVNKKQHKIETITKPTKPLSTLAVSTGCNKNQKLTDIITELSIFEKNKGLQHKYSAYRKAAQSIRAHPKEITSGIEAQKLDGVGKKIAKKIQEIIDTGELKKLNNQLKDETLTSIGEISKVSGIGPKAAQKFYDEGIKSIKDLWKIKDRLTHHQQIGLKYFNEIEQKVPRNEIEQFEELVRQALLKIDKKIIYETCGSYRRGLPSSGDVDILLSHPNYTLKMKDKKETFHIVEKLVDSLKKSGIIIDDLSLGPFKYMGICKLPSNIKLDNIDCKKEKNDHYSDNDDDEKEEEGNDNDDDDDDDCSTKKINSNNEEDATSDGEEFEDDSDATEPEDESKRLPPKKILKKKTLKLEKENIKKPKTTTKTTTSSKNSENNNNNNNNNKTINNNNNNFNTHIARRIDFKLIPIESYYFGLLHNTGSDEFNRQMRAIALSKGYTLSEYSINKFSKESGKDDQIIPVNSEEEIFKIIGMKYYPPQERKL
The following text describes a protein:
Function:
Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MQSSAASVTNLSRSNSKITYRAGSPSILAPSSVQAPASNDPPETTVREYRAYWLYGAGLAASGGIGRLVGLFLIDDLVKGAGVYEQTSLPCSGPSPVNGTTPNCVLPIGGSYINTVSYLGFVATVAVIIQIFVLLGLSAFGDYGFYRRSLLIITGVVGAGASIIIPLAYTPSLYWLAGLLLIISTSFQGFSTVFLEAYFPLLVRCDPLVKFHQIPAKSNGNPSDTSTRTKNSQERQINDFGQVIESVVLKTMPYHERANWVQMYNNVYGFATSFIFLSVGGGLISVVGNGIGIKEGVICATGVFWLIVGVIAIRYLNARPGPKLSHGTSRVIFFSWKKALQSFKNRKEIKHTFRFLASYFFFGGGMNTLGVVSALYLRDILQLSDFHTLTIGNLIPVFSILGSLACVQIQNKSHISTHIMLLVSVSMFALIPVYALIGAFTHTFGLVHAYEAYILSAWGGFFYGSSVAFTKVMYSELIPAGQECEFFGFYVLTDRVSTWLSSVIIGFIAQGTSARYGMIWLIVFFLVSLPLLWMVDLDQGRHDAKILSSGSEQEVVIMQDFVPQGAEYDREFPEQEDKNDFPMKVDPYPSNSQPSRANSPSPYAASTRSRTPQPHDSPNANTSYAKENSSSRDTLYTSHPNMSDQPPYPTMPTSIATSTAFRPPPSNYGTAGGSIRSDTLSTTAAKGTLPYAQSQVPAIQMPPSVHASSLDLSEFPYMENRPSSRPVNS
The following text describes a protein:
Function:
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLGSAFWLTLATLLGLCLGFAREWLLVASWGAGERSDAFLIALFLPEALRMSLAGGVLSAAALPLFLERQGERRLDWLAAILPALLGIAVALSLLLLAAAPWLVRLLGPGLAETASAQAAANLRVLAWCVPGLMLHALFSIPLQAAERFVLAGLGSLLFNLPPVLYLALHGQASQPEQLALACLLGSLLMPLVLLPSLWIEGWRPWHWRLSGVELGELGGRIAPLLLSNAASQGLALVERLVASLLGEGAVTWVNLARKLMNLPLIALMSLNQVLLGMMSRRQGGERLALLRRGLETASLLTLPAGVGLVAAAPGLVALLLPRQTAGSPLPALLAWFAVPLVFGAWNALLARYAYAAGDTRLPLRCELLGSALNAALLAVLPLIFGLPGIPLAALGGVLCTALLLMRRQALLGALPWARLWLLNALAMALAAGLLFRIDGIWLQLGLGTVAGCLALLGMALWLRPWRTD
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MIKNTVRIINKNSNTFINIRNNNNNNINSSLKSGFGTIKRFNTTLNHNSSNSNIQTPISINSTIINNNNNSNNNNSNNIINNDLNVVKFSTISTPNSILDTLNENHSNQTNNVNNKNYNNNNNNFEKDDKFGPPNNQNNNKLDLDTSKLYVSKSTGELFFTFMILKVCSINFISDNSQKFLNLFEKLGLSKPLNFFIKYSFFKQFCAGETIRETEIFTEKLNKLGIGTILDYAIEELAGSSEGFDSVAENICETIRVAAKNPTNSFSCVKFTGLVTPSVLEKMNTLVSNVTTNVSELPIESFNSPLDFYLNQSSSLMKQGSEPLLTSKDIKEIKEFFNRMDKIFQLCHQRGVPILVDAEQSYYQVAIHHLTMSYSIKYNKEKPIIYNTYQMYLVNGMNVLKQHFELSSSQKFNFKLGAKIVRGAYMVTESERSQRLSTENPVLPTIQDTHKSYNTALDFLLNQIKSDPNSIGLMIASHNEDSINLGTKLIKQYKIDPTNPNIQFGQLFGMADFLSFNLVDQHQRIFKYVPFGPVEEVLPYLIRRMHENKGFIGSNSDKELFYLKKEIKRRLF
The following text describes a protein:
Function:
Involved in protein export. Participates in an early event of protein translocation (By similarity).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYQVLLFIYVVVAIALIGFILVQQGKGANAGASFGGGASGTMFGSAGAGNFLTRTSAILATAFFVIALVLGNMNSHKGNVQKGTFDDLSQAAEQVQQQAAPAKDNKNSDIPQ
The following text describes a protein:
Function:
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MIVCCGIAMNEGLKIFTDCEFPLVVDLSGTMEPAFSRGDLLMLSNYTDEPIRSGDIVVINIHRISMPIAHRVIEVNEEEVGSTKYLTKGDENVVDDRGLYEPGQKWLERRHIVGKVKGVVPYLGKINIFIHTNVVLKVQKEQEKLKRQSSSACSLSVAVYFPRSGSCQAARLWVGEGGI
The following text describes a protein:
Function:
Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L-gulonate. This protein specifically binds 2,3-diketo-L-gulonate. Is not able to bind either L-ascorbate or dehydroascorbate.
Subcellular Localization:
Periplasm.
Sequence:
MKLRSVTYALFIAGLAAFSTSSLAAQSLRFGYETSQTDSQHIAAKKFNDLLQERTKGELKLKLFPDSTLGNAQAMISGVRGGTIDMEMSGSNNFAGLSPVMNLLDVPFLFRDTAHAHKTLDGKVGDDLKASLEGKGLKVLAYWENGWRDVTNSRAPVKTPADLKGLKIRTNNSPMNIAAFKVFGANPIPMPFAEVYTGLETRTIDAQEHPINVVWSAKFFEVQKFLSLTHHAYSPLLVVINKAKFDGLSPEFQQALVSSAQEAGNYQRKLVAEDQQKIIDGMKEAGVEVITDLDRKAFSDALGNQVRDMFVKDVPQGADLLKAVDEVQ
The following text describes a protein:
Function:
Structural component of the gap junctions.
Subcellular Localization:
Cell junction, gap junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MHVRKMMSTPAKEGHSHADQGVQKLKSVRLRQLDGSNSGADRRSSTATGKRFIRPRSRFAGVIDRLRWRTFTKVSNYCSLIDALISANSAAAWFKASEQGEILLLNLKQNGLIGAMSVPIKLLWQLGEKKGIEQPRESIGSIDVSDTLNWKATPVLLAICAFIIGGSQAFGEPISCIHPLEIKVWYKYVSTYCFLEGSYSMGPNNNLSTVAGMHKMDRKVLQMENPVEFYQWVPFFLSLQLIMFLSPGLFWKWARKRQSLDLDSIIEHAEAIRDSMGDPDARDGKMHDIVEYLDENLRASTDRDRCSLTILLLVVKFVTLMNAAYQFIFLVHYIGEGDAFFGYEIIQSFMAGSMTSRFFPLQVLCDLSFSIKLAQSQDYTMQCLLSLNYFHDKMFGLLWLWYIFLITYSIVTFILFTFSLLPFESSIRPQFSTSLYETNKNSIREFYHKMLLTDGIVLLKFISKLKGHNLSSEIAGRLFTKYEQIEALSAWVYPHSLKTKPMNMKTYNEYQN
The following text describes a protein:
Function:
Probably binds to the cytoplasmic part of the holin during lysis inhibition and stabilizes the holin-antiholin complex thereby resulting in a robust block of the hole formation.
Sequence:
MIKQLQHALELQRNAWNNGHENYGASIDVEAEALEILRYFKHLNPAQTALAAELQEKDELKYAKPLASAARKAVRHFVVTLK
The following text describes a protein:
Function:
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Sequence:
MWTDRLYRVEPYRMLFQWVKDEGNGIYSVGMASILAALAYPLYSIKIKPVGTKLEYDEALAIIEAGKRVATFPTPLSGIVVDVNEEVIKNPELINKKPYSSWIAKLKATNLEEVKNLQSAKEIVKTVKDFIILEDVDCSIVEE
The following text describes a protein:
Function:
Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level. Catabolism of gibberellins (GAs) plays a central role in plant development. Converts GA9/GA20 to GA51/GA29 and GA4/GA1 to GA34/GA8.
Sequence:
MVVVSKPAIEQFSSYLKNNKPTTLFTQIPLVDLSKPDSKHQIIKACEEFGFFKVINHGVPMESISMLESEATKFFSLPLCEKQKTGQPQPYGYGHKRIGMHGDVGWVEYLLLTTNQDPSLHSFQTFRSVKQNTKRNGNSFCFLGVFQFYLLFFFFRVALNSYMKSVKKMACEILEMMADGLKIQPRNVLSKLLMDEESDSVFRVNHYPPCPNVQPLNGNGNGNGDVIGFGEHTDPQIISVLRSNNTSGLQISLREGSWISVPPDQTSFFINVGDSLQVMTNGRFKSVKHRVVTNSVKSRLSMIYFCGPPLSEKIAPLPSLMRGDQQSLYKEFTWFEYKKSAYNSRLADNRLIHFEKIAAS
The following text describes a protein:
Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.
Subcellular Localization:
Secreted.
Sequence:
MRTWACLLLLGCGYLANALAEEAEIPREVIERLAHSQIHSIRDLQRLLEIDSVGAEDPLETSLRAHGGHGAKHASEKRPVPVRRKRSIEEAIPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECTCTTAGPTPDRREEEAGRRRESGKKRKRKRLKPT
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
METAKDNTARTFMELMRVPVQFYRTIGEDIYAHRSTNPLKSLLFKIYLYAGFINFNLLVIGELVFFYNSIQDFETIRLAIAVAPCIGFSLVADFKQAAMIRGKKTLIMLLDDLENMHPKTLAKQMEYKLPDFEKTMKRVINIFTFLCLAYTTTFSFYPAIKASVKFNFLGYDTFDRNFGFLIWFPFDATRNNLIYWIMYWDIAHGAYLAGIAFLCADLLLVVVITQICMHFNYISMRLEDHPCNSNEDKENIEFLIGIIRYHDKCLKLCEHVNDLYSFSLLLNFLMASMQICFIAFQVTESTVEVIIIYCIFLMTSMVQVFMVCYYGDTLIAASLKVGDAAYNQKWFQCSKSYCTMLKLLIMRSQKPASIRPPTFPPISLVTYMKVISMSYQFFALLRTTYSNN
The following text describes a protein:
Function:
Catalyzes the formation of unsaturated digalacturonates from polygalacturonate or short oligogalacturonates.
Subcellular Localization:
Cytoplasm.
Sequence:
MSIFTDLNTSRKWQIDQWLSAVNSHIEKIQQYGHSVVNPTPLLADGFEIKTQSPVVWQFPDGHDAPISNFASQQNWLRLLISMSVITETEKYRHLAFCQSEYFLNRFVDENSGLFYWGGHRFINLDTLASEGPESKSMVHELKHHLPYYEFLHQVNPEKTRHFIQGFWNAHVEDWSCLDLGRHGDYARQRDPDVFLHSRHDVVTPANWPELPLTKGLTFVNAGTDLIYAAFVYARHTGDAHAAAWGKHLYRQYVLARNPETGMPVYQFSSPLQRQPVPADDNQTQSWFGDRAQRQFGPEFGAIAREANVLFRDMRPLLIDNPLAMLDILRHQPDAEILTWVIAGLKNYYQYAYDVNSNSLRPMWNNGQDMTDYCFKRDGYYGKAGTVLKPFPLEGDYLLPLVRAWLLSDDDDLHTLIVTMLSRLEKQGIHQSASPFLLLAITELAHAKQSAQWAEYAWQMAEILFKRYFHHGLFVRSEHHRYVRLDDPFPAILLTLIAACRNKWSEVPAVLTQGGYIHGDYRINGESRVIYDTEFIYPEKLIH
The following text describes a protein:
Function:
Could be implicated in synthesis of very long chain fatty acids.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDIVKNYLIAFDQYTANFRWESGVTPLSSYVFPFSTSVIYVLVIFALQAIMKNKKGMVLKGFSIIHNINLIILSFSMMSGVMYAAYQQYLEQGAFSLVCEQSSQSVQGRIGFWIYIFYLSKYYELVDTVILALKKKPIIFLHIFHHMAMVPVTWQWLHDQWLVGSWWCTLVNSFIHVLMYYYYLQTTLGNPCWFKKYITKAQIVQFLTGTAMVSYWFVIRDSEKCQAPLSPAIVSNTINSFFIILFGKFYYDSYKSNSRRQEKLNKVE
The following text describes a protein:
Function:
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDQKARIKIDGVIVCEGKTDQAKLQQIFDVDVITTNGSALKKETINLIKKISEKQTVILLLDPDQQGKKIRSKLEQHLTNYYNCYVDMNARLKNAKKAGIAEMETSALIAALNNRVAITKNANQSILWDQYLSLKLNDKKKRLLLCNNLNLPYFNHKQLFKKLNLLNLTFQDVWKHLK
The following text describes a protein:
Function:
May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity).
Subcellular Localization:
Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
Sequence:
MAAGQGGWLRPALGLRLLLATAFQAVSALGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLPLDPVCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI
The following text describes a protein:
Function:
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Sequence:
MITAEQFQRQAAEGHTRIPVVREVLSDLDTPLSVYLKLADGAYTYLFESVEGGERFGRYSIIGLPARRVYSFRGHTLEVSEHGEVLETREVADPLAEVDALRAEHSVPQLDGLPGFTGGLVGWFGFECIQYIEPRLGSGEKPDELGTPDILLMLSEELAVFDNLKGRLYLIVHADPRQPQAYVRANRRLDELAHRLRQGGAGYPQAQISDAIDESDFHSSFTREEYHAVVRKAQEYVRAGDIFQVVPSQRLRVPFRARPVDVYRALRALNPSPYMYFLDVGGTQVVGSSPEILARLRDGVVTVRPIAGTRPRGATPELDKALEEELLADPKERAEHVMLIDLGRNDVGRVAEPGTVKVGEQFVIERYSHVMHIVSEVTGTLKAGLNYSDVLRATFPAGTVSGAPKIRALEIIRELEPVKRNVYSGAVGYIGWHGDADTAIAIRTAVIQDGYLYVQAGGGVVYDSDPDLEWQETMNKGRALFRAVAQAAKGL
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MSWLFTRKSEEKQKPDGEHEATASELLSGTEFDPAVLHPLANLGGSLDYLNIEEDTLSNLPGDSHAIPSRGWQDDLCYGTGTMYLGGLAVGGLWGLKEGLKKTENLQVKKLRVNGILNSVTRRGPFVGNSAGILAMMYNSINSFIGYKRGKHDWTNSVAAGAITGAVFKSTRGVRAMGISSAMIAGAAGAWCLLKRAFS
The following text describes a protein:
Function:
Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.
Subcellular Localization:
Nucleus.
Sequence:
MGVPAFYRWVLEKYPKCVVDCVESRAVVLEGERHFELTDTTGPNPNGFEVDNLYVDMNGLIHPCAHPESGEAPKTEEEMYRRVMAYVDRLVAAVRPRRVLYLAIDGVAPRAKMNQQRARRFRAAQEAEQRVEVEKEALEYMSAMGHKVPSKQEKPWDSNVITPGTKFMAKLAKHLRFYIRDRVNNNATWKSIKVVLSDAGVPGEGEHKLMEYVRVQRSQPDYDPNQHHVLHGLDADLIMLGLATHEVKFSILREEVLFGKQKYERERQKEQQMVLDANGVSGKRKRGEFGEHDADLVASDLKPLQYLHIATLREYLQVEFEPLSRVLPFEYDFERVIDDFVFLCFFVGNDFLPHLPSLDIRDGALDFLILIYAKLLPAMGGYIADGGHVNLSRVDVILAEVGQVEDVIFQRRAIKQAENERRRKSRLSNEKRDQIGAAAAKDSATEILKKRRIDKDTIAADKKYGGLTAEEAVKARVKESVEKKLEQYREEVQDIVRLGEPGWKTRYYSDKLKADDIEVGGGRERVFHAYIEGLCWVMRYYYTGCASWQWFYPFHYAPFASDLRNIDRFEIKFEEGLPFHPFEQLMGVFPAGSGHAIPKPYRWLMSDTESPIIDFYPKDIPVDPNGKAMPWLWVVLLPFIDEGRLLEAMKEPNQKLTEAEQKRNARFGKEVVFFHSKCPVTANPPTTELAEAQADPRISQSFNGTLVYIEALYFPIGGIVPSPEKAQRYLVDIPNNQCYSFQYRLPPTLPHLSKILDNAQPPSPVLITENDKRITIPFFGKANINIVDLAGDPTHHTNVRQNYMSRHNGGGGGRGGFGGRGGRGGRGGQQGYQQGNQRYNNNLNVDRYGGPPQQQQYNQYMANGHGNWGSQEPRNKRGQYNDSYNQYNGGQSSYGRPSSDYRGGYNGGGNSGRGYQGGNGGRGYQGGFGGRGGRGAPIQSAFGGSLQPAQAYPSNHIGSAAPAAPAPRGLEALKAGLRSMHQQRQGNPNGPPGRDTTRYDR
The following text describes a protein:
Function:
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma.
Subcellular Localization:
Secreted.
Sequence:
MRQRGRATLLVALLLLVQLRPESSQWSPAAAAANVVQDPNLRWNPGVRNQGGGVRALLLLLAERFPRRAGSEPAGERQRRDDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK
The following text describes a protein:
Function:
Transforms N(2)-succinylglutamate into succinate and glutamate.
Sequence:
MTKSLFRQSFLFDSLDLDHPMVAQTVRTEQGVTLKLHQRGVLEVIPAQTDAATKNMVISCGIHGDETAPMELLDKWIDDIVSGFQPVAERCLFIMAHPQATVRHVRFIEQNLNRLFDDKPHTPSTELAIADNLKVLLRQFFANTDEHSRWHLDLHCAIRGSKHYSFAVSPKARHPVRSRSLMQFIEQAHIEAVMLSNAPSSTFSWYSAEHYAAQALTLELGQVARLGENLLDRLLAFDLAMRDLISRHKPEHLPRKSVMYRVSRTIVRLHDDFDFRFSDDVENFTAFMHGEVFGHDGDKPLMAKNEGEAIVFPNRKVAIGQRAALMVCKVNTRYEDDQLVYD