lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Sequence:
MVSSSNLGFPRMGENRELKKLVENYWQGKVEETQFQKELKEIRINHWKLQKEAGIEIIPSNDFSLYDQVLDHIHLFGAIPKRYTPVVESEIEDGSNGLRTYFAMGRGYQTSKAATQVSETNTQGAFASKVEKSIDVGSMEMKKWFDTNYHYIVPEFEDSQQFKLTNYGGYSEPKPIHEFLEAKSIDIETRPVVLGPISFLLLGKSSDSSKPYSSKFDSLVHLNALLGVYEELFKQFEKIGVKSVQIDEPVLCFDLFETELIKNAYTTAFNVIHKAAPNINILIATYFGEIRENIDLITSLPVNGIHIDTIRSSSSEVESVLTKIPTSWTISIGIIDGRNVWKNDLTKSLVTLKNIIAKTGSDRILLAPSCSLLHCPHSLTREIGRVESQVLDWLAFSLEKLKEISFLTYALNKCTFTTENTITFPEDTCSKIKEYYQLNKESNQKRRESKLIHNDIVKKRVTEITPSMLKRENPFPVRREAQRKRLTTLPALFPTTTIGSFPQTKEVRLARSNFKSKKITPEAYDQFIRDEIRKCIKVQEECELDVLVHGEFERTDMVEYFGEYLAGFVFTQNGWVQSYGSRCVKPPIIYGDVNRPVPMTLEYTTFAQTLTTKPMKGMLTGPVTILQWSFVRDDQPRSETCFQIGLAIRDEVTDLENKGIACIQIDEPAIREGLPLRLSDWNQYLKWAIDSFLLSSTGVKDSTQIHSHMCYSDFNDIFESIQRMDTDVLTIENSKSDLKLLKAFEKYGYTNEIGPGLYDIHSPRIPSVEDMKDRVEQMLKYLSTNLLWINPDCGLKTREPETTRLALINMVKVAKQFREIYANKE
The following text describes a protein:
Function:
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (By similarity).
Subcellular Localization:
Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1179 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
Sequence:
MWGRKRPNSSGETRGILSGNRGVDYGSGRGQSGPFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMTHPEGVASLLPPDFQSSLNRPELELSTHSPRKSSSFSEEKGESDDEKPRKGERRSSRVRQAKSKLPEYSQTAEEEEDQETPSRNLRVRADRNLKIEEEEEEEEEEEDDDDEEEEEVDEAQKSREAEAPTLKQFEDEEGEERTRAKPEKVVDEKPLNIRSQEKGELEKGGRVTRSQEEARRSHLARQQQEKETQIVSLPQEENEVKSSQSLEEKSQSPSPPPLPEDLEKAPVVLQPEQIVSEEETPPPLLTKEASSPPTHIQLQEEMEPVEGPAPPVLIQLSPPNTDAGAREPLASPHPAQLLRSLSPLSGTTDTKAESPAGRVSDESVLPLAQKSSLPECSTQKGVESEREKSAPLPLTVEEFAPAKGITEEPMKKQSLEQKEGRRASHALFPEHSGKQSADSSSSRSSSPSSSSSPSRSPSPDSVASRPQSSPGSKQRDGAQARVHANPHERPKMGSRSTSESRSRSRSRSRSASSSSRKSLSPGVSRDSNTSYTETKDPSCGQEAAAPSGPQLQVLEPKEKAPTFSASVRGRHLSHPEPEQQHVIQRLQPEQGSPKKCEAEEAEPPAATQPQTSETQISHLLESERTHHTVEEKEEVTMDTSENRPENEVPEPPLPVADQVSNDERPEGGAEEEEKKESSMPKSFKRKISVVSATKGVQAGNSDTEGGQPGRKRRWGASTAATQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEKEPEAELPAPPQVSVEVALPPPVEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKAEEQGAPRPLHPPPPPPVQPPPHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTESQIVQKEAEQAERAKEREKRRKEREEEEQKEREKEAERERNRQLEREKRREHSRERERDRERERDRGDRERERERDRDRGRERDRRDTKRHSRSRSRSTPVRDRGGRR
The following text describes a protein:
Function:
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
Sequence:
MSSLLERVRGHSRASSGSREFLEATKRDALNLLEKELDKLLSTAPDNEKEKIRKEFDGFAALFGRFLEETGPSVDWDKIEKLPNDAVRDYSTLETPTADTIHNMLNKLVVVKLNGGLGTSMGCHGPKSVIAVRNELTFLDLTVQQIEHLNKTYKVNVPLILMNSFNTDEDTQKVIRKYKNLQVEIHTFNQSCYPRINRDTLMPITKKIDIHNDLESWYPPGHGDFYQSFKNSGLLRKFIQEGREYCFISNIDNLGATVDLNILNMVLNPKDKVQHEFVMEVTDKTRADVKGGTLIQYENKLRLLEIAQVPKEHVDDFKSVKTFKFFNTNNLWAKLDAIERVLAQGSLSLEIIINNKSLNNGLNVIQLETAVGAAMKSFEAGIGINVPRSRFLPVKKTQDLLLVMSNLYSLKNGSLVMSPQRMFPTTPLVKLGDNHFAKVKDFLGRFATIPDLIELDHLTVSGDVTFGRGVSLKGTVIIIANHGERIDIPSGANLENKIVSGNMRILDH
The following text describes a protein:
Function:
Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MSSGRRSEGAGCITWWGFSPALDLLSLGPEGSEEEIKVLLVGSGDPRHILKTIAGLQEKRLHVYVIETHMELVARQLLLLYIALIPQEIMGISEKTEVFLEVFGNSEIRSQTEEIVRQAASQLHLFVTETIETSPHDCLNTTYLKFKERDELAKILKSWTRPSSPQHPAPISMSKAWDYRVRQHLGTRYDSPEGCFDWDLNMKLHKKGCGVINKQQYEQWRKRGLAFEMREGIYQIPNPTLLSSRVLSRTGDSVAYRGYWGDIVSSPYLSFGVETDDKSLLKTQNGKHIKTAQDISFANVQGLFQTLSSRRSCPATSEPEKETEKPSMQPDLKSLRIKDLMHLTGVSLTILPLESVHKLPDKQKYSNFFNFMYFSVSCVHQLGPMMGQIAAPDAVLVVELAKYILDLSKEQEAGVAKKAASLALEAGFEARHDGSIDDVHAVFVQQKECF
The following text describes a protein:
Function:
Hydroxynaphthalene reductase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA. The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening. 1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone. The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN. 1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone. Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN. Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin. DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize. DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins. DHN-melanin also plays a crucial role in fungal virulence, including a protective role against the host's immune defenses. DHN-melanin also protects conidia against amoeba predation.
Subcellular Localization:
Endosome.
Sequence:
MVNTCTYLPLSGKVALVTGGGRGIGAGIALELARRGASVAINYGHSAKSAQEVVEAIQAIGRQAVAIQADLTCVPNIESLIQEVVRHFGRLDIVVSNSGMEKFKPLEETTLEDFNEVFNLNTRAQMFVARYAYDHIQPGGRVILMSSIAAGLGVPGHALYAGSKAAIEGFTRCLAADFGRKGCTVNAIAPAGVKSDMWRENAWRYAPGCDKSSSLEEIETALASGSPLKRCGVPEDIGKVVSFLASPDAEWVNGEFFSPPPCKGPLPGGDLEC
The following text describes a protein:
Function:
Functions in the late secretory pathway. Required for the generation of secretory vesicles as well as for actin polarization and polarized growth.
Miscellaneous:
MISCELLANEOUS: Present with 7500 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Sequence:
MDEHEEAVIFGICLVDFHHKRGPEIEYWYGLPEGTQSAELWPNLPFQALPDGSHSFEETFTYFTLLYDERRQRSPPNGATDLSDDSINDNTTLFAISCSRQIKSDELVTKDKDVTRSTVQKAIVVISRQPIFGQIKDKLSIVTNAFFLQHDFGDRKIIQSLYENLKSIYTPASLVRNAENRLYIGLCLRKILHDFKRNALVLLKAIMLEKKIIVYGNDVEALCNLQFGLISLIPDLMSNLQDSGSPQLFQDISKLNVVDSFKSSNRESVLRFLGFPLPIFEKGGLFSPYTPLQQMNDIRSERTLFFMIGSSNTLLAEQKEELCHIFVNTDNSTVDILDKTLNPVLQLSSHDKKWIESISGIVSDTWNENDDETPKNSQFEGSEDFIRWQFEDYLTGLLSSVKLSDYLDLHKENDQALKTIPEDMLNSNPVHLFNLNWVQSWKETQNFLIFNSRTDDRLFDLFPPKHIYNGADTLSLLQQRFLATFHNLKRSSSNSSSNKNGHQSEEDIKDQESIESKKSVSQISVNPGKNTDKPAANLWNSWKEYFNKPKNTANEDVTESTEDLKNRSKTSNAIQKAMMGLGLHYKPDAETDQQSEEVGNSEDNEDDDTDEDSEDDDDDGGDDDDSEDDDDDDDGEGDENGDDGEGDENGDDGEGDENGDKEDSQDFSNGFTDVTNINTDHDKENEQNFEGNAENFNEDETVADKDIEGGPESNKNSDSKTDIYENDRNVEDSSKTRNTVKKSNEEGGANDAAIGNCVQDEEKL
The following text describes a protein:
Function:
Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-64' of small ribosomal subunit uS12 (RPS23A and RPS23B), thereby regulating protein translation termination efficiency. Part of a messenger ribonucleoprotein (mRNP) complex at the 3'-UTR of mRNAs. It associates specifically with components of the translation termination complex and is involved in both translation termination and in regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.
Miscellaneous:
MISCELLANEOUS: Present with 8910 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus.
Sequence:
MKRKTAEVKGEKERNSKQISLEEDKIKGMFNPKIWDKTFQDGLKKEIEDSQPYNWGTIHELVNDDLLRAVRKEIETEIHFTKKETDIYRVNQSGDLANLSGLDWDDLSRLPNLFKLRQILYSKQYRDFFGYVTKAGKLSGSKTDMSINTYTKGCHLLTHDDVIGSRRISFILYLPDPDRKWKSHYGGGLRLFPSILPNVPHSDPSAKLVPQFNQIAFFKVLPGFSFHDVEEVKVDKHRLSIQGWYHIPQVGEEGYIPGEEEAWVRNNTSTLAQIESNVLEDFEFPKDERNILSFHEVKHFEKMLKGDAGAKTDNTPKESMTSVISDSVKLSEAEFTYLSQYISPEHLSSKGIEKLQKQFVENSSLQIESFLNDDKSELLKKVIKQKELEQECPYHSKDVKAPWKTAIPPHKARYLYIDGKEYRNFQTEADILEALNNNDLPNFQFTKDAIKIISDASGNSRENNFDAELALIDLAVFHKSTIFKKYLALLTSLCPVSEQILIRRFRPGMDFTLATKCRFNELLKSNPDIIDAVLEGTLCLTPSAGWESGELGGYELYMMDDDEDNKQYLKEDVEDASVYRADDSGDSVLINDPPAWNTFNLVLRDESVLEFVKYVSWSAKSSRWDVKMKWDVKSCDEDGQEDEA
The following text describes a protein:
Function:
Transcription factor that binds to 5'-TTGAATTGA-3' elements in the promoter region of target genes. Functions as a repressor of the ecmB gene. Regulates the differentiation of prestalk cells during development.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic in growing cells. Translocated into the nucleus in response to cAMP-induced tyrosine phosphorylation. Nuclear at the tight mound stage and in the upper, prestalk region of tipped aggregates and in cells at the tip of the slug. Subject to crm1-dependent nuclear export.
Sequence:
MSSAEFSMDDFEDTFDSNATISTKDLFEGSDRLPLNQSINTTIQNLYLPNGGFAIGDQSQQQYYQAMPPLNQSDQFNLGRSNNLTPRTNQLQQLQQQQQQQQQPQQQQQQQTYGTQSPIHMSQTPSSPLSSPLPSPTPFSRQQSYNNNNSNNTSSSQNYNNNNININNNNNNNNTNNNNNNNNGNNSNGNNGNNNNNNNNNNNNNTNNNNNNNQQQQQQQQQQQQQQQQQQQQQQQGNPNLSSPQPILDTIYKLLSEQEQTLVQMIHEQSLLLNRLPPTLDENSLAPLKSLSQKQITLSGQMNTEMSALDATKKGMILEPTDLAKLFALKQDLQIQFKQLSLLHNEIQSILNPQHSAPKPNVALVLKSQPFPVVISKGKQLGENQLVVLVLTGARSNFHINGPVKATMICDSHPTNKNNPTTPLEMDSQPIYPATLTAHFPLKFLAGTRKCSVNLKFGVNIRDLDNVTTTVESDASNPFVVITNECQWEGSAGVLLKKDAFDGQLEITWAQFINTLQRHFLIATKQDPVRPKRPLSSYDLKYIQTHFFGNRSIIHQQDFDKFWVWFGKSMQTLRYQRHISTLWQEGIIYGYMGRQEVNDALQNQDPGTFIIRFSERNPGQFGIAYIGVEMPARIKHYLVQPNDTAAAKKTFPDFLSEHSQFVNLLQWTKDTNGAPRFLKLHKDTALGSFAPKRTAPVPVGGYEPLNS
The following text describes a protein:
Function:
May function in growth cone guidance.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MRRILTLLLLFNVVRSSEAITGGVVNLRPKQIINSVGIGDRFGGIGTSSDESDHFKLLAADGDSLLVGARNAVYNLSLSTLSVNHKIDWKPPAEHIEECIMKGKSKTDCQNYIRVLARKSAGVSLVCGTHAFSPKCREYTVTEFGIRNTRQFDGQGISPYDPKHNSSALYVPGTNQLFVATVTDFVGNDALIYRKTIDETPSSKSAANIRTQSYDARVLNAPNFVATFAYKEHVYFWFREIASEAIDNNEEPQIYARVARVCKNDKGGARPANERWTSYLKARLNCSLPSGSSPFYFNELKAVSDPIDAGNNNHVVYTVFSTPDSDVRMSAVCKFSMKKIREEFDNGTFKHQNNAQSMWMAFNRNEVPKPRPGSCSPDSTKLPENTVSFILHHPLLHRPIPSVAAPLLVEGADRADLTQITVLPRVRAVGGHNYDILFIGTSDGKVLKVVEVDGNATVIQSATVFQRGVPIVNLLTTKESVVIVSADEIASLPVHNCAQQTSCSKCVQLQDPHCAWDSSIARCVHGGSWTGDQFIQNMVFGQSEQCPEGIIVREVFDDNESEAQPEAVSRSGYPKEHSTITVVLVAAVASLISLIIGAFIGIRVNRWAATSEPHRSASSTSGSDYDSFGRARLTRHDSLTTATKVDHGFVPQSKQSVDATSLVMSINATHHPMSMSQHGSGINTPSRDKNAIVTSINQNTLPRDYKVKKVYL
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles (By similarity). Involved in the regulation of ciliary length (By similarity).
Subcellular Localization:
Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the apical cytoplasm.
Sequence:
MPSETLWEIAKAEVEKRRSHGSEGDGAEIGEKSVFFIGSKNGGKTTIILRCLDRDESAKPTLALEYTYGRKTKGHNTPKDIAHFWELGGGTSLLDLISIPITVDTLRTFSIVLVLDLSKPNDLWSTMENLLQATKSHVDKVIMKLGKTSSKASAEMRQRMWSVVQKDHPDRELIDPFPIPLVIIGSKYDIFQDFDPEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSLCQIGSPPVPDSDIGKLQAHSPMELWKKVYDKLFPPKSTGTLKAVQDPARDPQYAESEVDEMRVQKDQELEHYKRSSSKTWKQIELDS
The following text describes a protein:
Function:
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
Subcellular Localization:
Cytoplasm.
Sequence:
MRVKIAVLPGDGIGPEVVKQAIKVINVLSKKFHHQVEIKEGIVGGAAIDKFGDPLPEETWKICEESDSILLGAVGGPKWDNLPGDKRPEKALLKLRSGFNLFANLRPISIFDELIFSSPIKEEYLKGVDFIIVRELTGGLYFGKPKETRIENGEEIAIDTMIYRTSEIRRIAHVAFKMAQKRKKKVTSVDKANILECSRLWRKIVEEVAKEYPDVALEHMYVDNCAMQIVRNPKQFDVILTENTFGDILSDEAAVITGSIGMLPSASLGETKKGLYEPIHGSAPDIAGQNVANPIATILSVALMFRYSFDLEEEAKLIEKSVRKVLSLGYFTKDLYANNPYAQKMVTTEEMGDLICSVIEGGA
The following text describes a protein:
Function:
Serine proteases that hydrolyze many proteins in addition to elastin.
Subcellular Localization:
Secreted.
Sequence:
MLRFLVFSTLVLYGRSTQDVPETNARVVGGTEARRNSWPSQISLQYLSGGKWYHTCGGTLIRQNWVMTAAHCVDRTMTFRVVVGEHNLSQNDGTEQSASVQKIVVHPYWNSNDVSAGYDIALLRLAQKVTLNSYVQLGVLPQEGAILANNSPCYITGWGLTKTNGQLAQVLQQAYLPTVDYAICSSSSYWGSIVKKSMVCAGGDGIRSGCQVNARGKGQKSHPRSFPLCLPPPTFFLTPFSTPTPTPMHRLDFLLWGLSENESVPVTLYSQHLKVERNPKIHPAPCPDLKSLCVAPHWCVDVCACSLEAVSHLGLSRPRVVVVIVYKEALLPSTSAFLVAPPPLPLYLCSISRRIYR
The following text describes a protein:
Function:
Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
Subcellular Localization:
Nucleus.
Domain:
The N-terminus is required for dimer formation, association with RFXANK and RFXAP, assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y; The PxLPxI/L motif mediates interaction with ankyrin repeats of RFXANK.
Sequence:
MAEDEPDAKSPKTGGRAPPGGAEAGEPTTLLQRLRGTISKAVQNKVEGILQDVQKFSDNDKLYLYLQLPSGPTTGDKSSEPSTLSNEEYMYAYRWIRNHLEEHTDTCLPKQSVYDAYRKYCESLACCRPLSTANFGKIIREIFPDIKARRLGGRGQSKYCYSGIRRKTLVSMPPLPGLDLKGSESPEMGPEVTPAPRDELVEAACALTCDWAERILKRSFSSIVEVARFLLQQHLISARSAHAHVLKAMGLAEEDEHAPRERSSKPKNGLENPEGGAHKKPERLAQPPKDLEARTGAGPLARGERKKSVVESSAPGANNLQVNALVARLPLLLPRAPRSLIPPIPVSPPILAPRLSSGALKVATLPLSSRAGAPPAAVPIINMILPTVPALPGPGPGPGRAPPGGLTQPRGTENREVGIGGDQGPHDKGVKRTAEVPVSEASGQAPPAKAAKQDIEDTASDAKRKRGRPRKKSGGSGERNSTPLKSAAAMESAQSSRLPWETWGSGGEGNSAGGAERPGPMGEAEKGAVLAQGQGDGTVSKGGRGPGSQHTKEAEDKIPLVPSKVSVIKGSRSQKEAFPLAKGEVDTAPQGNKDLKEHVLQSSLSQEHKDPKATPP
The following text describes a protein:
Function:
Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.
Subcellular Localization:
Nucleus.
Sequence:
MGVHALWDILGPTARPVKLESLSNNRMAVDASIWIYQFLKAARDKNGNRLKGAHIIGFFRRICKLLYFGIKPVFVFDGGVPPLKRETIRQRKERREGKRESAAVTARKLLALQVQQQGDTAFKGNSRSKSEGSVTFRPSDEYELPNIPGFLYDERDERVMSTEEYKAVFEHLDELDGIDLESINPASKEFDELPNATQYLILSTLRLRSRLRMGYTKEQLEEIFKDSMDFSRFQIEMVKKRNFYTQKLMNTTGVHDGGLSKLDLEHSRSRVAGQRQKEYTLVKTEMGWAMSLGEYDGSEASKAIPLDDAAIAPTRPVQSSWSGNDVEDSDEDNLEWEDIDIAPKKEKKVADYSLKASAIPTTIVEGSSTGSQSFLDRPFRNSGKLRQPERAIQFVDDNSTDSDREYLDYVEETTNMEELKKTRGNLAGVEHRVSKHNPYKTAPDNATSEESLKDLSEVEEVPRKPGTRNDAQFPLQHKGTHNIMTDKINSELNDRMIPDVHTLPSINLGKGSFLFDIKTSKEESSSSGETKPEQRKINQDVPLWFNSVPTTNPHTATGFVSDKETSTFTEDEKLGIFSGVAATELMRQNVSSTDLESLEKELDGDSNDLEELTQLNKEHTEPTRAPDIPKGYLLKDTTQRSKEESTFAYDFPEEEEEVLVEQLRKEHADYNRFKHTLDPSIATTAFIEDELYEQNTKDKRDADEVTPEMIRDIQQLLSIFGIPYLTAPMEAEAQCAELLRLKLIDGIITDDSDVFLFGGSKVFKNMFQEKNYVEYYNTETISAELGLDRLKFIALAQLMGSDYTNGIKGIGPVSGIEILANYNTLEEFRTWYNEGQFRKSLLDKESLFQKNLRKKLTKSGVVLGDDFPSAAVSDAYLNPEVDHDTTKFVWGLPELDSLRTFLGSTLGWPTEKADEVLIPLIRELNKRRSKGTQSTLVEFFPTKFIDADKGAKLGRRIRDATVMLKKRRTK
The following text describes a protein:
Function:
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Sequence:
MDAVLSRLKGLTADELREEIIKANLKCGPITATTRAIFERKLARALVESAGLTEPDASGDNSATLDRSVVPSSAASATPDAITGEDGDFGYGMGLNPPEEEALSGTVCACNVENTQTPSKTAQVSPTFYGVCPLWEDVLARNERAHVYTDKKEALQAVKMMKGARFKAFSNREDAEKFAKGICDYYPSPSKSTPCVSPVKPGLVFSKDHPSMIEADTINREKANSFKSPRTQDLTAKLRKAVEKGDELGFTELVWSNPRYLIGSGDNPTVVQEGCRYNVMHVAAKENQPGIVQILLDTLENPEFMRLMYPDDLESMLQKRIRYIVDLYLNTPDKAGFETPLHFACKFGCPEVVNILCSHPDIDKNCKNKYNQKPCEVICERMKEKGKVQEVKQKINEYLEERLYIPLLRATDNSSQAVIGAPWSPEPMESLSPWLPRSPKDPVMAVRAFAGPLSPSKADEFRRAWKTPPRERADHFHNILKSDPDRGAERVGRDLAHELGHPWAEYWDFLDSFVDLQSTEGLKMLEEYLSKKDFRERAHEEAGENETSNRFKTPSPGKLKKFCNSISVGAFLDEGDDISLEEIKNRQNAALTSISSVCSKDGLQGAVGGLEFHILPVSHSADLIEAAAEQDLLLSEKSMISSSKNGLCEQGSGDRTPNGDKVSPRICGSSNSCMLSPISNLMAEFERMSLLDEPDRTNRERRRSGGKRQTTELTSGLGRLSLSSEDDSVFEKDRTSALRAAENDGTERRNEVDVRSSASSDEYFLASERLEPINQQTIDTSGCERMICARSKSWDHGGRDLSSSGSSSSYRSLDSSQDFILRTPPRVTKGLFIEGDSPTKLDREVLSALGVSDFDPLKFPSIHKWKSTIQTYSQSEMQSWLTPAVHKSHLRALSATPGSPVSGLMSPVSRFSPARHMGSPDNCSPGRYSPAHSTYSPAHPNYSPVSYIQRIRLKHFGDTPI
The following text describes a protein:
Function:
Tethering factor involved in vesicle fusion at the trans-Golgi network (TGN) thus being required for efficient protein trafficking to the vacuole. Implicated in resistance to salt and osmotic stresses. Modulates the cell morphology (e.g. epidermal cell file rotation (CFR) and cell expansion) in mature regions of roots and the base of hypocotyls as well as root skewing, a process leading to root movement within the soil in order to maximize anchorage and nutrient acquisition, probably by regulating microtubule stabilization independently of their orientation.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein.
Sequence:
MHEKDDLPQDSIADGIENDDESNGQEEEELDPDQGTAFVDSKEDMFVDAPEELNFDTPSKEALTTDDDDNDDLGTHFNIEKGDWEKELAGLQEQFKLLTGENDLTGEDGNTTVDIVSRFSKFLKTAKEERIQHEVALKELHGVISGRDDEIADLTTKISELSSSQPVSEMGDQAQNLEHLEAATDRIMVSLSNVFGEGELQYGSSISEKLAHLENRVSFLGAKYTEFYYGADQLRKCLASDVLDLSFQEDFGSALGAACSELFELKQKEAAFFERLSHLEDENRNFVEQVNREKEMCESMRTEFEKLKAELELEKTKCTNTKEKLSMAVTKGKALVQNRDALKHQLSEKTTELANRLTELQEKEIALESSEVMKGQLEQSLTEKTDELEKCYAELNDRSVSLEAYELTKKELEQSLAEKTKELEECLTKLQEMSTALDQSELDKGELAKSDAMVASYQEMLSVRNSIIENIETILSNIYTPEEGHSFDIVEKVRSLAEERKELTNVSQEYNRLKDLIVSIDLPEEMSQSSLESRLAWLRESFLQGKDEVNALQNRIESVSMSLSAEMEEKSNIRKELDDLSFSLKKMEETAERGSLEREEIVRRLVETSGLMTEGVEDHTSSDINLLVDRSFDKIEKQIRDSSDSSYGNEEIFEAFQSLLYVRDLEFSLCKEMLGEGELISFQVSNLSDELKIASQELAFVKEEKIALEKDLERSEEKSALLRDKLSMAIKKGKGLVQDREKFKTQLDEKKSEIEKLMLELQQLGGTVDGYKNQIDMLSRDLERTKELETELVATKEERDQLQQSLSLIDTLLQKVMKSVEIIALPVDLASEDPSEKIDRLAGYIQEVQLARVEEQEEIEKVKSEVDALTSKLAETQTALKLVEDALSTAEDNISRLTEENRNVQAAKENAELELQKAVADASSVASELDEVLATKSTLEAALMQAERNISDIISEKEEAQGRTATAEMEQEMLQKEASIQKNKLTEAHSTINSLEETLAQTESNMDSLSKQIEDDKVLTTSLKNELEKLKIEAEFERNKMAEASLTIVSHEEALMKAENSLSALQGEMVKAEGEISTLSSKLNVCMEELAGSSGNSQSKSLEIITHLDNLQMLLKDGGLISKVNEFLQRKFKSLRDVDVIARDITRNIGENGLLAGEMGNAEDDSTEAKSLLSDLDNSVNTEPENSQGSAADEDEISSSLRKMAEGVRLRNKTLENNFEGFSTSIDTLIATLMQNMTAARADVLNIVGHNSSLEEQVRSVENIVREQENTISALQKDLSSLISACGAAARELQLEVKNNLLELVQFQENENGGEMESTEDPQELHVSECAQRIKELSSAAEKACATLKLFETTNNAAATVIRDMENRLTEASVALEKAVLERDLNQTKVSSSEAKVESLEELCQDLKLQLENLRVKEEKWHEKEVELSTLYDKLLVQEQEAKENLIPASDMRTLFDKINGIEVPSVDLVNGLDPQSPYDVKKLFAIVDSVTEMQHQIDILSYGQKELNSTLAEKDLEIQGLKKATEAESTTELELVKAKNELSKLISGLEKLLGILASNNPVVDPNFSESWTLVQALEKKITSLLLESESSKSRAQELGLKLAGSEKLVDKLSLRVKEFEEKLQTKAIQPDIVQERSIFETPRAPSTSEISEIEDKGALGIKSISPVPTAAQVRTVRKGSTDHLSINIDSESEHLMNNNETDEDKGHVFKSLNMSGLIPTQGKIIADRVDGIWVSGGRVLMSRPQARLGVMVYSLLLHLWLLASIL
The following text describes a protein:
Function:
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSASAGGGGGGDSGGSSSSSQASCGPESSGSELAPAAPAPRMLQGLLGSDDEEQEDPKDYCKGGYYPVRIGDLFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLRWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLATEATEWQQSGAPPPSRSTVSTAPQEVLTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAAQAEDAGSRLEGGSGSTSSSGCFSGSLFSPASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLNP
The following text describes a protein:
Function:
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Subcellular Localization:
Nucleus.
Sequence:
MGVEPEEEGGPAEEEDFSRAMEPSDSGAAGGSRAVCDQGAPSRIASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSDEVPSVTMSGHVYNNQSVNLHSSTHVRLAVGSQIAAEMREAMHNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEMPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGISVAQRIRKLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKTKIEELLSSLLNRVCHDGRKPHTIRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNYDAVPPLMEILMKLFRNMVNVKMAFHLTLLSVCFCNLKALNSAKKGPMDCFLTSSLSTTACSGKRSFKVKDIHMEDSYKEKEANWDCLPSRRIESTRRGESPSDATCFPKEKDTSDLPLQFLPEGVDQEVFTQLPADIQEEILSGKSRENLQGKGSLSCPLHASRGVLSFFSTKQTQAGCLSPRDTLLTGKQASAVSPCEPGTSGLSTSSSSHPSCGKDCSYYVDNQLKDERMSQGPTESQGFHFSNTNPAVSVFHSFPNLQSEQLFSTHRTADSHKQTATTSHQGLENREQDSADEKLTFPSDIDPQVFYELPEEVQRELMAEWKRAGAEFPSVHNTGTLPPRSQHESHTQHTRMAPLFAAQSLPRSVFRTRRRAPLQDKPEQRF