lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MADGDSDRSEDEMRARYKDENEFHLTDEQKKAARKLTQMPDGVNSNAIYKERSEIREHYYTMSNKVQEATRELAENGKTDLLDTEEGYNEVEGMLTKAHGFYNKIGASTKELACDAHFMKNISQLMLASIQKLHKAHIEKTLRPKDFVEKILETSTFYNDEPIKLISSDPSTSDLLDDSDDEEEFRPNNAKKRCMELFVLVPDGVENDGVMPATQWASFGRRFGSFLKIAPTLTYFRPLLQETAPLPQQPKAKRERLPKDDKSKAKAVVLCEKDKNHDDPDQSVTRELDCIRKSLRREMRKQKSRIIPYYWFVIDPTDFSKSVENMFYTSFLVKDNHIRIEIDQQKGLPMIVLQAAEGDDEFPLSATAAPSTIDAAAEVAGENCTATQQAIVGFAYDIWEGMIECLNITEPVIRR
The following text describes a protein:
Function:
Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: Incomplete sequence.
Subcellular Localization:
Secreted.
Sequence:
MLSLDVLLLCAISGFQLLISADGDPMIEVFKWKQLDFYNRGDGYKDLWNRICIPDSHFYNSRKCLGSSSSGSFIQYNNVPQGVTHFRGRLFVTVPRRQPGIPSTLNYIDLAKDGWSQSPHLRAYPNLAVNQYNASEQNLVSVYRTSVDVCGRLWFVDTGMLEFPNNRQQIRHPSIWVIDLANDRLLKRFEIPQSIVEIGRGLASITIDVGARRCNDAYAYIPDLVNRRLHVYHLRSDRIWSFEHSFFNFDPLSDNLNIGGQTFRWDDGIFSATLGSYKPDGSRDVFFHPMASTNEFVVSNRVLQQEFNAARSDHGDDFHLLGTRGPSTQSTMHKYDPRTGVIFFAEVQKSGVGCWKTSKPFSTENHGSVYSNSSEMIYPSDLTIDEEGYIWVMSNSMPIFVYSKLDVEKYNFRIWRQSTLLAKRGTVCE
The following text describes a protein:
Function:
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous:
MISCELLANEOUS: The reaction proceeds by a bi uni uni bi ping pong mechanism.
Subcellular Localization:
Cytoplasm.
Sequence:
MTKVIEALSDWQSIRKTINDLSVGFVPTMGNLHAGHLSLLERSKCENTITVLSLFINPTQFNDKNDFKNYPRTLAQDIAMAEENGIDYVLAPTDDALYPDQYAYKITNSTINNQEAEFRPRHFDGVLTVVMKLLLLVKPTRAYFGEKDYQQLQLVKGLAEAFFLDTEIIGCKIVRNEFGLPLSSRNRRLTEDQYQLAQRFSEIFHSDLSCDEIKNALIQEGIIVDYIEDYNERRFAAVHVGDIRLIDNIPFAKDKKC
The following text describes a protein:
Function:
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape.
Sequence:
MSVTTATSGALIFSGASLLVSLFAAASIYSQVSSIWTELDNEIDSFKLLTNDIWGDMINLGAGSASNRIRRQAYGGYGATGTNAPEPQFPQGDKGPLPVPGLPFGPNVSGGSDRCQCTVENTCPTGPDGEEGEQGPDGQDGVDGVPGFDGQDCPDVEQQPSQGCFTCPQGLPGPQGSQGAPGIRGMRGARGQPGYPGRDGQPGMPGEMGPTGAPGDDGAPGASGMKGDDAEKPVGRQGQRGQPGEQGPDGEEGPAGKDAFEGPPGVEGEVGVPGYQGSAGPDGEEGPRGPSGLPGKDAEYCKCPTRDDGGNSHRAWRRKHKRVY
The following text describes a protein:
Function:
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MALSLEEFIHSLDLRTLPRVLEIQSGFYFEGSIYEMFGNECCLSTGEVIKITDLKIKKIMAEICEHVEGCVSPQSFELPMNFPGLFKIVADTTPYLTMEEITKANHIRPSRPNHPCFYHQKDIKLENLIIKKGERIMLNSVEEINGEIMVNCSVLRNHQNHSFTLPLSQEGEFYECEDEHIYTLKEIIQWKIPKNRTRTVILTGFSAKWDSTNPFPRGFYGAVILKPVYEIQAVMKFRKDIVRILPSLDVEVKDITDSYDANWFLQVLSTQDLYEMANKQFPIVAEVIEAPQGNQLPISILQPGKTIVIHKKCQASKILASEIRSNSSKRHFLIPTSYKGKFKRRPREFPTAYDLEIAKSEKEPLHVVATKAFHSPFEELSSVSVGDEFLVHHSQTTEVLCEGIKKVMDGLACEKILKNSREVALLPLYMDGGFVEVIHDKKLYQISELCAQFRLPFNVKVSVRDLFIEKDILAAIPGLQLEESITNSYLLISDLANPKKCWEIPVGRVNMTVQLVNNFSGDTGSFLVSTLVEEITEEQYYLIRRYEKSFLHPPPRPPKHPSVEKIELTPLSLAKQKTVNLPKSPKSVHVDRSKKLYSNQAGLDSKVPAGCQNDLADLEKEKRKTEATAVTEIFKTEEHKK
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Sequence:
MKTNLHDITKKALWNVSTTKGGYEISAMFDGSNETFWQSDSVPPHYIIAQFSKKTYISKLSMYISIQNDETYTPVEVACYIGSDPNLMQQYSREELSILQGWVDIPLGISTIFLKIEITKNHQGGKDSRIRQIKLWGLPQSLTFDTSCFVTSNATQFLTIR
The following text describes a protein:
Function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Subcellular Localization:
[Phosphatidylserine decarboxylase 1 alpha chain]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain; [Phosphatidylserine decarboxylase 1 beta chain]: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
Sequence:
MGLPIETIKDDLKREKGQVQVMSTLPLKAMSRIWGRFNELEIPYYLRVPGFKLYSFIFGVNLSEVAEPDLHVYPNLASFFYRTLKPGARPLHPNPNALLSPSDGRILQFGVIESGEVEQVKGMTYSLDALLGTSKPATTPNPADPSNIFTPPQDTKPKQSKARYSDGDEEIIKQDEKFATVNGISYTLPNLLSGPPQEQPGKSTSDASTTPKAASEAEVRADLALGEKPWYSRLTSENKTALYYVVVYLAPGDYHRFHSPTAWVVEKRRHFAGELYSVSPYLQRTLPGLFVLNERVVLLGRWRWGFFSYIPVGATNVGSIKINFDRELRTNSLTTDTAADRAADEAAKRGESYSGFAEATYEAASPILHGHALRRGEEMGGFQLGSTVVLVFEAPKGERPSLDEGWMGQKRKGGWNWAIEKGQRVKMGEQLGWVDGA
The following text describes a protein:
Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Domain:
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
Sequence:
MSVFLGSSAQFSQATIDPEKIKLADIQFSAMAFTFNKLLRRCEQKCLLREYGEGELTKGEQECIDRCVSKYVKANVIIGEHLQKQRLDPFNSMPEYRKVQDILASSVKS
The following text describes a protein:
Function:
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.
Sequence:
MLEENIKPYQIRVYEEAIHHNVIAFMDSNDYKTLVSIMLIDAITEKLPLVHVQPSQQTYSTSENNLAVSTYHIQNSETLNSRKTIVCVGTKGAVKEKANEIHQYTDLVVRGYSGEESSSISHLDYNHWQKEFSNSQVLVMPQQLFVNLLTRKYLDLSKHICLIIFDECHHSRNAQEHQAIMNGFYCHIPVRSPRPKIFVVSSIPIHSISMNLKDLEKNLKDLMVMFSCQTVVVPDRRQDNIQPRNTDVTVLEYDSTTNDFNSLFTFHSTDSHDRKELQSYFCKLPQARDGGNAFSDESYTVSTQQLDDEIAAAQHFIQLQHDTVSIDSKRLIVTEKQLKRIRATFSELGVWCTIKLVKEILGVTHAAASKKRKAVHLDDTFTDTDWQSSLKSSSTNSLPSQNDYTSISEIPTADISIKVHTLLKTLAKNHNQSTDTINFGKQPFQSLVYVHDDQTAEKLCNLIQCSAFQKYPFIRCGFINGSTIHMMNTESPSYSVSHSVVDHAFEKGTNSTQNTLQRFKSRELNVLVVSNFGQNRCHLPKCGLVILFDWPRKQLCYERLKGYTGGVPGSQFIVMVAKGHSKLKKAIAKAESIASFSCSVVQKLYRFKKSSHQEDLQNDMVPFLTLVKTTHVDDLVGPLLFGKRKSVFRTRKGTILARADAKRVLDFYLVSKSNSEQLDWPTSIYQTVKNGYKSISNYMPWDEYLLKISQQYLEKVYATSESDPKHENSTIIHGAGINADGLLYSGSTRFDIDLSDSEMVAKMCPKEPNIGYICVVKIPQWLTLKIDTIIGMWQLTEKLACEDSALEACRVLYNMGELDERLQPRTPVKSLSKSTIDATKTVHSNIVLPDSHSNQLPQNHTNHETGHHRSIPHSFSNFSSKLGTTNKTETHSRFVTVIDINTTHSNASLVLQSAAALLTDSSSDQLQTDSTLALLTTGALPGNALCATELWCDLSFSYTPVDIHPWSKSGKVTTATETKFSAQEYEQILRFQHQFWNLVLQNHDRCNCVFDESLSASTSKKNDCSNNDSNSNLYYEVVPMYRQSGCDWAINWDLVELVNSRREVSFSEWVSLCTTVLEPHSLITVQNVIDSGITPPNACFPSHQSLYRIFSDPRYDHSSLRKLVNEISPLHNLPGKYSTCFSAPIVDLTKDIIVYTPHNNIKYQIKCWSENCNAYSELTIGKGKGQHITTYQAIASSQGYTVDHPNANLLKCVRIPHIKDYRRSCQATKNKHNCVDDNQNLDNLPQLVPDAFRVSPISAKLTMVAHYLPSILYSLHTACLAAEFDQKYGLYPKQIPLSTLMSAFTTPAANSITNYERLETLGDKVLKFGVAHYLHSSYQSYEVGQLSTILSGLVSNKNLFEIAQQHSLTGMLNTAPFQSNSWTPPSFCFETRIFVAPTASVDCLDNRVFCGKKQSDFIEALLGAYFLECGVEAALHLMRTFRLINEIPPHCFRHGDTNKLHDHQISSMQNPILSRLDQETVDHVQQKLSYNFHNPELLLIALMTPFYFVKSKFERLEFLGDAIMDILVARYFYRHYKHADPCSLSKMIQATVCKPAFCKILVSLKLHEHLLQSSQLSQHSKEAIVLYANYIQNSHSQHAFKQADKAIDGPKVLCDVFEVIVAAIFIDTGYNLERTRLVIFPYVHSFIQSNINLETITEPPIRQLFAFVQSQGFSSEKLELSDESNADGFHKASVVFYGTVLATSQATTLKLAKQHASIKALNVLKHTKKATLKDMVNLNSCKQSTL
The following text describes a protein:
Function:
Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
Sequence:
MTSKVARTQPYRVGESISKAKMLPRPRTLTELVAGLHHIFEDNDIEVEDVKNYLSSYVAKDEEWKHLAKFDPHRYTRNLIDEGNGKFNLILICWGGGQRSCIHDHSDAHCFMKVLQGDLIETKFEWPENDQAPMTPCGNEYVHRDEVAYINGTL
The following text describes a protein:
Function:
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous:
MISCELLANEOUS: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MESIDIVRKQVAESERVKAELSKNEEVIAAIAKAADVCTEAYRRGNKTMFAGNGGSAADAQHLVGEFVSKFYFDRPGIPSIALTTDTSVITAIGNDYGYDKIFTRQLQAQGVAGDVFIGISTSGNSKNIVDALPICKEKGITTIALTGMKSCKMDDFDIVIKVPSAETPRIQECQTLIGHIICCIVEENIFGEEYNK
The following text describes a protein:
Function:
Involved in microtubules reorganization during spindle and phragmoplast development.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Preferentially localizes to microtubules minus ends.
Sequence:
MQSLSSSAPTPEAILEWLQKEMGYRQLGPYNGSSKSHVPSIDAIRKICRGNMIPIWNFLINRVKSEKTVERIRRNITVHGGSSNASIGSSVNPGKEESKSKGRRKDKTVTGESSSYAEDREAALQERELAAKEVERLRNIVRRQRKDLKARMLEVSREEAERKRMLDERANYRHKQALLEAYDQQCDEATRIFAEYHKRLQVYVNQANDAQRSVNSSNEVLSSLSANSEREAVYSTVKGTKSADDVILMETTRERNIRIVCDLLASRMIERIRNSFPAYEGNGICSLPELETAKLGFEYDGEITDEMKTVIVNSLRGPPLLLQAIAAYTLRIKTLISREMEKIDVRADAEMLRYKFENNRVTDNSSSDVSSPLSYQFNGNGKIGTDTHFQGSNNQLLERQKAHVQQFLATEDALNKAAEARDLCHKFINRLHGSADTATHSFVGGTTQSGSNLRQFELDVWGKEREAAGLRASLNTLLSEIQRLNKLCAERKEAEDSLKKKWKKIEEFDARRSELETIYTTLLKANMDAVAFWNQQPLAAREYASATVIPASEVVVDISNSAKDFIEKEVSAFFQSPDNSLYMLPATPQGLLESMGANGSTGPEAVAYAEKNAALLTARAGARDPSAIPSICRISAALQYPAGLEGSDASLASVLESLEFCLRVRGSEACVLEDLAKAIDLVHIRQDLVESGHSLLDHAFRAQQKYERTTNYCLDLASEQENTISDQWLPELRTAVQNAQASSEHCKYVRGLLDEWWEQPASTVVDWVTVDGQSVAAWQNHVKQLLAFYDKESLRT
The following text describes a protein:
Function:
High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK
The following text describes a protein:
Function:
Stabilizes the ATG5-ATG12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Also recruits ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.
Miscellaneous:
MISCELLANEOUS: Present with 573 molecules/cell in log phase SD medium.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MGNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAIGGNIVSHDDALLNTLAILQKELKSKEQEIRRLKEVIALKNKNTERLNDELISGTIENNVLQQKLSDLKKEHSQLVARWLKKTEKETEAMNSEIDGTK
The following text describes a protein:
Function:
Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.
Miscellaneous:
MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium.
Subcellular Localization:
Preautophagosomal structure. Note=Also localizes to other perivacuolar punctate structures.
Sequence:
MIMNSTNTVVYIKVKGRRPQGFLDPPKFEWNGTKERQLWTMVSNLNYSQDQIDWQNLSKIFETPEFFLKKRTYKLFAEHLELLQLQLEKKRDLEKYSNDQVNEGMSDLIHKYTPTLQNDNLLNVSASPLTTERQDSEEVETEVTNEALQHLQTSKILNIHKKTSDSENKPNDKLDKDGINKEMECGSSDDDLSSSLSVSKSALEEALMDRLQF
The following text describes a protein:
Function:
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). Lesions in the gene coding for the enzyme cause dwarfism.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MAETVHSPIVTYASMLSLLAFCPPFVILLWYTMVHQDGSVTQTFGFFWENGVQGLINIWPRPTLIAWKIIFCYGAFEAILQLLLPGKRVEGPISPAGNRPVYKANGLAAYFVTLATYLGLWWFGIFNPAIVYDHLGEIFSALIFGSFIFCVLLYIKGHVAPSSSDSGSCGNLIIDFYWGMELYPRIGKSFDIKVFTNCRFGMMSWAVLAVTYCIKQYEINGKVSDSMLVNTILMLVYVTKFFWWEAGYWNTMDIAHDRAGFYICWGCLVWVPSVYTSPGMYLVNHPVELGTQLAIYILVAGILCIYINYDCDRQRQEFRRTNGKCLVWGRAPSKIVASYTTTSGETKTSLLLTSGWWGLARHFHYVPEILSAFFWTVPALFDNFLAYFYVIFLTLLLFDRAKRDDDRCRSKYGKYWKLYCEKVKYRIIPGIY
The following text describes a protein:
Function:
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell projection, axon.
Sequence:
MRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQRQEAEAAARALARFAQEAEAARVELQKKAQALQEECGYLRRHHQEEAQAEARDALKCDVTSALREIRAQLEGHAVQSTLQQEEWFRVRLDRLSEAAKVNTDAM
The following text describes a protein:
Function:
Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator PleD, leading to its activation.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGRHGGPAAAGPTAPSAVRAKAVNAPSQVFVRIAILAALLLLAVYTAFGVHRLQREAMAQPGGAPLAAKADLIAGRVDANLAAQRAGLSAAADLLKRDPGATMDAAETTLRAAGGEAAAVAVVSEAGVVAVAGRDDGADWKAAALAAGASGRTNWVGSVGETGRLYVATTTSLDRARAFVIASGDASRLVADPEKGESGALALPDGKLIAARGRGVQGAGALREAFALSIEDLGDGPAAVRGQAADGALLDVAVRPVAQGALLAVAAAPTRSVANLDRQVMEGAFSLLVPLGVGIALALLLMIQSRKAEVAHREFIDSERRFRLAVEAARCGIWEWDLNGDQVYLSDVTGAMFGWGGGGVVSGQDLLERISIDHRERVRQALANAAMYGAFDVSFRVPASEQGARSLWIDARGQGFGKPGSEGHARIIGVALDVTEERIAQARAQAAENRLRDAIESVSEAFVLWDRQGRLLMCNRNYRSVFSLEPKILKPGAARAEVNRFAALAIKQDHPAPDGAKGVREAEMMDGRWIQISERRTAEGGLVMTAADITAIKTQEEARRRNEEQLQNAVAGLERSQEQLAELARKYETEKVKAESANKAKSEFLANMSHELRTPLNAINGFSEIMMNEMFGPLGDQRYKGYSQDIHSSGQHLLALINDILDMSKIEAGKMNLKFESMHLEDVAEDAVRLVRNRAEAAGLKLDIDFPQLPEIEADYRAVKQVLLNLLSNAIKFTPRAGSVTVRAEVRRDPFGDLIKVSVTDTGIGIAKEDLARLAKPFEQVESQFSKTTQGTGLGLALTKSLITMHDGVLEMHSTPGEGTTVSFTLPVRHSDQKITRDFVAA
The following text describes a protein:
Function:
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.
Subcellular Localization:
Cytoplasm, Stress granule. Nucleus, nucleolus.
Sequence:
MAHEAFGPPLRETLSRWKREQAQLKASVIDHDTEAWQQKTDFTGLFRVGGVDISFIKGDDVRACASLVVLSYPELEVLYEEHRMVNLTAPYISGFLAFREVSFLVDAIQRLQKKKPDLMPQVLLVDGNGVLHHRGFGVACHIGILTDLPCIGVAKKLLQVDGLKNNDLHKEKIQHLKTGGDTFPLMGDSGSILGMALKSHNKSSKPLYISVGHKVSLETAVHLIQACCRYRIPEPIRQADIRSREYVRRTIELANSQEAEKERLKEIAGYDLGNSERSGEQATKRSESLPGFAASPASVPQGERRLLMEKQSYLWVRICWDRWYIECDLRQSPFSLQ
The following text describes a protein:
Function:
May be involved in environmental stress response.
Sequence:
MKGKPHANYGRLQIHHNTTTGAVCVWVAAGGGSQSYHLFIFPISPFSFSFFLQFLFTIFHLHHHISLIIHDSRISTPFIYQLIQNCRDPNSHETQDKTIEMGSDANKMNDATSFQPSEPALCANGCGFFGTAATMNLCSKCFRDLRIQDEQVASAKAAVDKLVNKVVSFPPQSAASPSSSLSPASVPETASQPSTAEEVKVSNRCLTCKKKIGVMGFKCKCGESFCGSHRYPEKHDCEFDFKRSGRDAIAKANPVVKADKVNRI
The following text describes a protein:
Function:
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg(2+) and to a lesser extent toward Cl(1-) in ASE left (ASEL) sensory neuron.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MIGVYLRSVIFPLLFVIQTICQPPGNVFHLGFLHCDVLENNVEGSTTYINYRTSASAASIAIDKIKREGLLLGYDFKFTILYDQCDENIAAGNAIKLFAEHNVDVLFGPTTNNAAMPVFILATYYNIPLITWGITSSATLDDESRFPTAGMLSIGSRSLAVTFREVMKEYGWDQFVFAYSLEMNDEKCETLRDDFQNMVAYYGDIVLSYAVQIMDHSEEGLLAILKDVSTRGRIIVPCFHEGNSRGLHRRWMLVAARNGFVNDEYVYIFPSLRSRGYAVPQADGTFRYPWTEATGPQPGDQEALLGFQKSIFIVDMQGQGNVGSNYTQFEHEIIQRMKEPPYNCTDACASPEYQTAATYAGQLHDSVYIYGVVMDQIMKTVPNQYKNGTAFPRKMAGVFNGVGGTVAIDEGGGLQPTLFVLTLDSNNNSSLIMTVDVDQQEAVVTKHYTNEATALWSHRKGIRPPDQPICGYTGSLCPANVFFQYIGWFIAAIIIIFFTIMGAILAFIYLCHAKQQEVERQNALWQIPFKSMMTVTKKGKGEHSMRSISSVPSTISSTRSSTLSEVGETRNYLFFQIQNDVEMERVAAKKHSIRMVFDNKTCATMRQMRLIDHANLNKFIGMSLDAPQLYSVWRFCSRGSLADVIRKASMQMDGFFIYSLMKDIINGLTWIHESSHEFHGMLTSKNCLLNDRWQLKITDFGLRIFRTHDQYNKSDRLWTSPELLRTDDILGSREGDIYSFGIISAELITRSSVFDLENRKEDAEEIIYMLKKGGLQSPRPSLEHDESIEINPALLHLVRDCWTERPSERPDIKQVASQLRSMNTNRNDNLMDHVFNVLESYASTLEDEVAERMKELVEEKKKSDVLLYRMLPRQVADKLKLGQTVEPETFDIVTLFFSDVVSFTTLAGKCTPLQVVNLLNGLYTIFDGIIEQHDVYKVETIGDGYFVASGVPRRNGNEHTRNIASMSINFVKSLADFSIPHLPGEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNSKPGQIHLSEEANQMLMRLGGFTTEPRGEVIIKGKGVMATYWLLKMDESAAPKILKKKQD
The following text describes a protein:
Function:
Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.
Subcellular Localization:
Nucleus. Cytoplasm. Preautophagosomal structure.
Sequence:
MELMSHILERYLRMFPTNHEPSGTFIWSLGHSYATETGKWPEAFVQDTYDLLSLTYRKCIAGMECFSSDAGWGCMIRSMQTMLANCLRRVQPSLPVHKILHYFADEANAYLSLHQFVDAGHTLCNITPGNWFGPATVSHCAAHLCSTHPQVGLNVCVSHDGAIMYRDQLRNTPYPRLLLFTLRLGIDTIHTSYYEQLCHVLTIPQAIGIVGGRPRAAHYFYACQSQWFFYLDPHTTQTAHTFDNPAPNSSFHVTTLRRLRINELDPCMVLGFAITSEECQTDFEQRIVKLDKLVHIADTMPDNDSVDEDSVWEF
The following text describes a protein:
Function:
Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGSQEVLGQAARLASSGLLLQVLFRLITFVLNAFILRFLSKEIVGIVNVRLTLLYSTTIFLAREAFRRACLSGGAQRDWSQTFNLLWLTVPLGVFWSLLLGWVWLHLLEVPDPNVVPHYGTGVVVFGLSAVVELLGEPFWVLAQTQMFVKLKVIAESLSVILKSVLTAFLVLWLPHWGLYIFSLAQLFYTALLVLCYVTYFTKLLGSSESTKQRALPVSRMTDLLPSITRSGAFVNWKEAKLTWSFFKQSFLKQILTEGERYIMTFLNVLNFGDQGVYDIVNNLGSLVARLIFQPIEESFYIFFAKVLERGKDATLQKQEDVAVAAAVLESLLKLALLAGLTITIFGFAYSQLALDIYGGAMLSSGSGPVLLRSYCLYVLLLAINGVTECFTFAAMSKEEVDRYNFTMLALSSSFLVLSYLLTQWCGSVGFILANCFNMGIRITQSLCFIHRYYRKSPHRPLAGLYLSPALLGAFVLSGGITGVSEVFLCCEQGWLARLAHVAVGAFCLGMTFGTAFLTETKLIHFVRTQLRVSRLADKTS
The following text describes a protein:
Function:
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGIEVLYIAIGGAIGAVFRGVICILFDKCYKKKFPLAVFIINITCCFLYGILSKITFRKHYPEELHVALTTGFCGGYSTWSTFASQTFKLGKNKDYMIAVLNVVANHVVGFFFCWLGQLIGKKI
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MESRPDTKGMCHATVAATVPVLFMTLMRCGMAQTVTEPSSDKVTNLCTEAKYTEYLASRIVAVAERQEREISDMQIYSEAWNLLAASTNQTDKRAATYALATYMSTAAETARRAHAGKYKAAVATAKLLHRRSALTRTLLTMRIRGKTIVGISKEANGIGICPGEATPTLSGDSSCAHRTNDSNQPEGIAVNLKAATHIKLLNSSALRPRGLTHLVEIKETKWPASREALVERCGGLLGGDHYVKFEASTTGEDSKIIVEPIKIFEGDDAEKNCAVVQKESMKSEKDNDLLINKICTYITILDPQIITISSLTPAMLANTSTVQMAFKSFVHAATGKAPSDGEIELQLKSLYGGDKQNFTRDFVKILWTKNVTYHTGAGFKTETLLDAVRNKNAQRALIYLEDQRPAEESKQTQTDESEINGPVCGGEGQEECKLDEKKDPEKPNGTQMRKWPKALQWMITRQGGNCKTIQQEDCKEDCTWDEGACDGAVGISASMNISLFMAFLLLA
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLSKKMKICRPSLVLIYLWYLVDCTSFSMNSVTCLRLMQLLLAKYYQIPIDLVGEKLSIVSASSCLLQYLVALVVVPFYSTIIKKLTPWFTVFTTWVGEEYFFFASTLSILYMDDFPTCAYFVIFSISFLLGISGTGPSLNASYKSLCKLYSYENSFIVVLNSIFVVSSCIGPFLGSILLLRVSLLQLYLISWTIHFINFVFHSLLAVFFSSKYTSYAQKEGQPILNATENLEVEYNALNTTPSSFEEQPLLNGLNDSPRNPVSRTNAEGFKALNASFDGSYKFPIPIVLLCFFLYSLLTPFFDIHLQFQLIVMHMSIVQVGFINSVKTFGSLLTCSVCLFLTYVGGFSVHMMKTTMLIGLTATTLIIFILYFATAQTLPCLALFYGITSSIGPSIHGLVAAYVPNDKPHRYWKFTALLEASATFISYPFQSLAFIVCLKYCSFYFFIGPICICLLGSISSYLLLGYH
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein.
Sequence:
MSWFPGFGAPKSNLPAVTPLQAQRSKQIDSLRALNPNVVELKRDEEYRVGFTCGVNHVTFTISLPADFPQTKPIITVAPPMRHGFLDESMQVVRYLPLINFNVQTDLGRLVQNMVQEFCKAPMFIQPDASQQRAVPTVPQYQHFMPQPTPTQQQLPPLQHPVPSHNPLQQHQTPPHSHQPTPPHHSSPHMTPPHPSMALPHSSMTTPHSSMATATPPNQYTPQMPAPHPPSSASSYPLTSTVPVATSSASSSARVAPVNGLDVEPNIPVPGMLGIRGLNDGHHYNMPAIPPSFNDLFKDYTKEQLQDLIEDDDKLDVIFRNVPQLSKMHIDRTELYQSCEEIAKLNLSYQPEIERLRREVEETVKFRNDLKNNFDMKCLQQQSLNEQCSLSHLMDNMRVSAADAEHQSDDLAERFLQDKVTLDEFLKLFSEQRKLLHIRKVKEEKLSQLIEGQGRY
The following text describes a protein:
Function:
May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor.
Subcellular Localization:
Lysosome membrane.
Sequence:
MSGPIGLEVQHPETEYRLKKVSEKFIESIHLMVNEPSVGLYRIQEHVRRSLPQLVDKKMELRSCQNQINGVCYDLDYSIKTVQSMQHIPHFTIIQECLRSAIASKKNLDAAKLERRSKKVDEGSGAQSADAVSEVSIETQDVEGFICPNCMQVLTSQDELLEHWQSQHETANDTRQGYNDDANNDQD