lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The MBT repeats specifically recognize and bind histone H3 di- and tri-methylated at 'Lys-9' (H3K9me2/3).
Sequence:
MLKLVILCFALFYNTVSSTRFLFGVEVKCDFDEVFQLTVSHWEDDGNTFWDRDEDITGRMTMFARKKIFFYQDGHHGFEFGKLEPYGWFLHNCTKNGNFREYRHGLSSTSGSNGLEYIEYTMSEFLKIVRANKKSDRKLDKTYLWESYLHQFEKGKTSFIPVEAFNRNLTVNFNECVKEGVIFETVVHDYDKNCDSIQVRWFARIEKVCGYRVLAQFIGADTKFWLNILSDDMFGLANAAMSDPNMDKIVYAPPLAINEEYQNDMVNYVNNCIDGEIVGQTSLSPKFDEGKALLSKHRFKVGQRLELLNYSNSTEIRVARIQEICGRRMNVSITKKDFPESLPDADDDRQVFSSGSQYWIDEGSFFIFPVGFAAVNGYQLNAKKEYIEHTNKIAQAIKNGENPRYDSDDVTFDQLAKDPIDPMIWRKVKVGQKFELIDPLAQQFNNLHVASILKFCKTEGYLIVGMDGPDALEDSFPIHINNTFMFPVGYAEKYNLELVPPDEFKGTFRWDEYLEKESAETLPLDLFKPMPSQERLDKFKVGLRLEAADMCENQFICPATVKSVHGRLINVNFDGWDEEFDELYDVDSHDILPIGWCEAHSYVLQPPKKYNY
The following text describes a protein:
Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAGDRHHISCSSHEAGRGASHRIWPSTISKSSSSSISRSSAMAADGSMVRRLYLSIYNWVAFIGWAQVLCYMTLALLDKGHEAVYAAIERPLLFTQTAAILEVLVTRYSFYGMKESFGFTPSWLLWLRYSTFIACFPVGVVSEICLAYTVLPFMKASEKYCLRMPNKWNFSFNYFYANVFFMAFYVPAPAAHSGSSSGRAATTAERRNRVTSGCNERYTHA
The following text describes a protein:
Function:
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Sequence:
MTETCVLITGGAGFVGSHVVVELLEAGESVVVIDNLSNAASDKDNLPPAIKRIQNIVNASQRKRLYFRKGSYGDRNIMDSIFNEFKIKAVIHAGGFKAVGESKELPMKYYKNNVKEALTLVKAMNDHDVKNIIFSSSATVYAEVPPEKLPLTEESPVGNCSCPYASTKLFIENILRDVTVSDGQWKVMSLRYFNPVGAHHSGMIGEDPKGIPNNLMPFIAQVAVGRRKALNVFGSDYPTPDGTGVRDYVHVVDIAKGHVAALKALPNMKQGFQPINLGSGVGTSVLEMVQAFERASGVVIKTVMQDRRPGDVASMYCQPTLAFEELGWKTEKTVDEMCEDLWRFQNQNPNGLHPSGESN
The following text describes a protein:
Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular Localization:
Cytoplasm.
Sequence:
MSCMSSEADGGGCGSGNSCSASAPVTAVVAGAPRLCIKCKDGVPAITVGNQTEPMCARCLHVSILSKFKTAVNNHGLITPADNVLVAVSGGPSSRVAVEMLKEIRSKAQNDADAAKDHVLKVFGLGVVYVDETTVLKLPRTDAEAAVVAIKEIYEGIPVHVVQLESVFETESSLVHENGGDNFARLQLVEDTADPKSKLSKLFESVQDATGREDLLESLRMQAIQVVAQSQGYTKVVLALTATRVAARVVAATTKGQGYSLPAYIQYLDGRWPVPVVLPLRDCVARELALHCHFSKLSTTFVRGLTTMTDPRSSLNNLAHHFITLLQEDNPAREHTIVRTAAKLTSFRFNAEVVPPSRRRRNPRNHDTSQEKSNREPEFLCSICRAPLKSSDMASAVGTPHQTESVEQNEEDTSGQYGDMKSTCCPSCLFQIFPEEGTQAAEKFLLFPKTTRDTASSNFHQRQQWIRSQIEDFLIPEGDDSS
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MTESVADTASAAVAQKIVMDYFMSIMTDRENVPVFYARDAVLSWENQNYNGQQQIKELFSKLPEQVTFKISGYDVQPVIRTDLLTTVIVFGTYQVSGFKLQDFHSVFYVYVRRNEGIAYIKYQVFTTF
The following text describes a protein:
Function:
Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein.
Sequence:
MLTGSTSAPPVRSLVLSPRDSSELLSPTGPLTPASTKGAGTSALSSKIASVLSTSYADTEFREALFLLDERGLQNVAENRRKLRLDLQKEVIDSNGEIIHEFGKVAEQLKRIGYTIGKLNESYNDMRTQIHAAHASTASTLGEASQLMTQKRQIESKQKLLSTFKTHFILTQDEVDALTLTSEPVDDLFFTVLAKAKKISRDCEVLLGFEDQTLGLGIMEQVTRNLNHGFQKLYRWIQREFKSLNLENPQIGSAIRRALRVLAERPTLFQNCLDFFAEAREHVLSEAFYTALTGSSAAGLEDPSVKPIELVAHDPLRYVGDMLAWSHSAAVGEREALEVLFISEGDEIAKGIQVGREAEVWRLVAEDGEEMNIFDPVVALNQLVDRDMSGAVRILRQRVEQVIQTNEETILAFKLANLINFYKSTFSRLVGPASILVEAMGTLETEALRQFRSLARDHVATLQTEFQHTPPDLRPPDFLTDALEQLSAIMKTYETSLSSSGDDPEAEFASIMAEAFDPFMAGCINMANHATPPSKSIFLINCFVAARTTLSGFTFVRKYAADIQTKIEEEKARLVIAQYELFRAESGLDSLIEALDGLDIRKKDDVGKVATLEEVQPEALRQSSQKLDDFLPSALIDATEKLKNLQDSKLASSVIEEAAERFCVDFEHVEEMLLSADELEEQRRVEEDGDEEHSQSFRALFPRTSSEIRVLLS
The following text describes a protein:
Function:
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
Subcellular Localization:
Cytoplasm.
Sequence:
MERLKNFVHSVVGCDAHIEYPCCVLGTIQREPQQLDEHLENSFYLFTYRRYFDPLPYSTLTSDKGWGCLARATQMLLACSLRRHSAQDCKLQYFADLDDEQVAPFSLHCMVRHILKQGESLRPVYWAPSQGCEAISGCVKRATERGILSSPLSVVITVAGAVPAEEVSCHLKESRNVLILAPLRCGASRYMSQKMFLSLEHLLLAPESVGMVGGVPNRGYYIIGTGAQELLLYLDPHCKTQDALLSSEPGETGVVKPTSSNLRSVPYGQVDTSFFLGFFVDSQSRWESLQKRIEGLSKQKLHPIVSVYRGGPHTPVDSLVMEWPTEP
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Membrane. Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MGFVAGVTGGATLTLGLTYLAISAHQRNRTHQSDLLRAQTRFVNTLARDTLPTNLRTRYPVNDEDLAYFPPPRSELVERARHRFVESVKDRWNQEIQNAVRWAQTKDWSSVREKAEDAVASLFGYTIDRSEYAAAKAKEAAKEAARIAAERMRYAAEEGKETGKIMAREAHARSEEMRRRAAETARLWSQEAREEMQVAKGVAQRVAEEVRHDADVVRGVVNSVVDKAVEKGRHGIEKVEEAVGMGKAAVELAEEKFEAAMDRKLLHVSDIDKALQERYTKREEVMKKSVQEVLAERYIPMDKRDNTRLRSLI
The following text describes a protein:
Function:
Ligand for members of the frizzled family of seven transmembrane receptors.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MLCRSIIGRLSPAHHYFCLRHHDVTEVAILGLRIALSECRYQFKNELWDCTNVMYHRALGKQISDPKKGFKESSVIFALLGASVSTQISRACSAGDLQYSLKKMAIVRCKCHGVSGSCQLKTCWKVAPDFRRVADVIKTKFKMAVRVGAFATNTIEYKIKNLSPKKFKDSLIYTQNSPNFCNPEPKLKILGTTGRQCNASSLDDNDCGSICCGRGFDIVVKTIVKKCLCKFKWCCAVVCRKCFVRRWVAICK
The following text describes a protein:
Function:
Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.
Sequence:
MERIVSRVRRLSPLHTFSDALLISLLSESDFQPDSIQQGVVLFEKDEPTEYWYLLLSGEVQLYSKTYTGDFNHLKTLRCGALFGDLSTLTHSCSCLVTRPAQLIRIAQNHFLSVYNKHGDHLQPFIIIMHDILTDETPSDPIHPHSSGLFNGQRSMDLISTEINPSEIVSVSTNGMLSKMILPSIPNQREKPMNRVVVNQQKNEERNFIEFHNPTGIEKQIRDSGGILHRKMLTDNHQVIRDITTEHTRVQNCMIGAEMIDWLLTLFVSTSTTCSSLSRIQMSAIWQVLLNNGLISHIDGEHQFLDKTNSYYRWVQQFRSRNKVAPSIEEVSKSITLLSSVAPETLFLMIVSKPGFERSPEELEVVYEELTFIKALSHLSTMVKRQLSNFVKVEQYVHAGSVVFRQGEIGVYWYIVLKGAVEVNVNGKIVCLLREGDDFGKLALVNDLPRAATIVTYEDDSMFLVVDKHHFNQILHQVEANTVRLKDYGEDVLVLEKVDIPRGAALENSNSCNFNCGYSVMAGKAEKILEYVLETRIDALGDDISELDVFVEDFILTHDAFMPDNTVCNFLKSYYFRTPYRATRDSITDSCTEEVRCKRRVVQFVYVWCSLLRVNFFLNPVTNSFVEELFCHVIDDRKRLGGMEDILTRIGSIRSTRENMQLVLARHPAIVLDCGVLSAHTPCPVLPSDVCNQIIYLADTTCFVLPIRVDKTAEEICELSRRRMSFSAEPLNLVEVKSNGEKLIFSPNDRAIPTVLSLNSKLYVVNREEIPLLVPMEDQNGPTPSSHSSILHLIDSQELAHQLFLFHLQLLRSTDSNELLYQVIGRESFPLSMPFNLDLLVRRFNEVQHWSTTEILLATEENRMEILKKFISIATIAREYRDLLTVFAITLGLSHTSISRLTLTWSKLPPASLKTFSELENLLDPTRNHRMYRLLVSKMSSPYIPFVPLILKDLMFIHQGNKSFYNGLVNFEKMHMFAKIFRSFRQCKSQMDNGAEHEFIEPQSLIRNLRVIDNQKKLMQLSYEIEPKSAPKRNVIFH
The following text describes a protein:
Function:
Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
Subcellular Localization:
Cytoplasm.
Sequence:
MQRGIAWIVDDDSSIRWVLERALTGAGLSCTTFESGNEVLDALTTKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVDRAISHYQEQQQPRNAPINSPTADIIGEAPAMQDVFRIIGRLSRSSISVLINGESGTGKELVAHALHRHSPRAKAPFIALNMAAIPKDLIESELFGHEKGAFTGANTVRQGRFEQADGGTLFLDEIGDMPLDVQTRLLRVLADGQFYRVGGYAPVKVDVRIIAATHQNLELRVQEGKFREDLFHRLNVIRVHLPPLRERREDIPRLARHFLQIAARELGVEAKQLHPETEMALTRLAWPGNVRQLENTCRWLTVMAAGQEVLTQDLPSELFETAIPDNPTQMLPDSWATLLGQWADRALRSGHQNLLSEAQPEMERTLLTTALRHTQGHKQEAARLLGWGRNTLTRKLKELGME
The following text describes a protein:
Function:
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.
Subcellular Localization:
Apical cell membrane.
Sequence:
MAVFHDMLLQPLGMFLCLSLQLSSATFIRYSSTCFTFDEYDPVTLDIKASSHIYEIFVPVNDSVYAVVMKTLDENSDSAGLWQRADENCYSNSTYYVKDQYTTVLEAQWQAPEPENITEVEIQAFTVQIRALPILSTLKLREKLSTLALAAKIPQSSAFKPFFMITPKSIRLEGLANQVFSSPITDAIYILLAFLTSTLLPKGKPGKQLFLPPLHSPTFSSKLVLGTECV
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MEPGSYIPYKYLPVLIAMIFATVFGLGGLIVNKIVAPRKFNPIKFIAYESGNPPSGEPKERFYIGFFLLAILFVVFDVEVIFLYPWAVAFDAISLEGFWMMIIFILLIFIGYIYEIFMGALTWHRK
The following text describes a protein:
Function:
Aminopeptidase.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDPEAGSRARGLKGVHRVSANSGGIGGVPGPHNGLTDVPGVRVGHAGRTGDGWLTGVTVVLAPPGGAVAAVDVRGGGPGTRETDALDPRNLVQTIDAVVLTGGSAFGLDAAGGVAAWLEEQGRGFPVGADPSQVVPVVPAAALFDLGRGGTWRARPDAALGRAAVEAAAARPEGDPVEQGGVGAGTGAVVGGLKGGIGTASVVLDSGATVAALAAVNAAGSAVDPATGVLYGARTGLPGEFAGYGVPDAIGADTHARARARLAEAAEETARRRAGGAATLNTTLAVVATDATLTRAQAQKLAGTAHDGLARAVRPVHLLSDGDTVFALSTGRRPLLPDRPDATAARAFGVHLEAGALNEVLAAGADVLTRAVVHAVLAATGVDTPGGVHPSYRELYARP
The following text describes a protein:
Function:
Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the hydroxyl group of 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde (HBC) to yield 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC).
Sequence:
MTLTKQDAVNQMMGFFQSKTLITALSLKLFDHLRDQDRNAKQMAALLNCPLRSSEQLLIALQAMGYLEKQDGLYHLPQEHRAFLVSDEPQWLGWLGRHIDTFLYPLWGELKAAVENDTHQRQTVFGDDRSWFDILYQNPDDVTDFQEFLGKFAAPFIDGFIQDYDFSQHQAFLDIGSGIGSLPIAVANAYSGVNLAICELPQTSTFLRDKLVQQGYGQRIQVLEGDVISGDLPIGDYDLIHLGWMLHDYAPETQLIILKNIYDAMPVGGRFIASETPLNADKSGPEFTALLSLNMLVSTDGGIESSPQEYLSRFHQAGFSNARIMDISGPRTLIVGEKTTHNNGSSQC
The following text describes a protein:
Function:
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MDASSRRPDRGLLLISNLPALQNLIKRDPDGYAAEFATQWDHYQSLRSVILLGLSVAGGGDLIGAGSTTQTGASGNNKGRRETEDKFREVIGFLAQTAPCFATKQNPIRSVKSLPSELSSLLLERHDRLHPDTRKALVQALVGIRRKDPSNCMLTNLELLHVLFGLLPLTTSPTLRASILKTILTDIKMANKKAKNQKLNRSIQGLLFSMVENGINLPSGIGGSALEGTGLKKTKSKSQNPEAKTSGREAMWAVKLASELWRKGIWNDSKTIRILADACFHFNTKVQSAAIHFFLADPESSAACADDQDSDNDQPQEINVRQVKHVQTINKKRKSTEKKTEKKIKAAAKLQRAKEAGASRVDSNFSALHLLQDPQHLAEQLYEALMRNDKVYTLEHKVLILRLFSRICSAHKLQVLPFYSYVLKYIVHHQLEVTSILASLAESVHELTPPDVLTPCLRKLANEFVHPGVASTVIAAGLNSIAQICRRQPLAMEPDLLADLIEYRKSKDKGVIAASRGLLGLFREVNPTILKSRDLGKKAAMEKQKARSDAPPSELVPGLSHKVVRYGEIRGQVSSIAGLDLLESVISSENRDRQDGDEEEGDELEGWEVASSDGDDSDSDRSGGWIDVSSDGASDLDVSDSSDEDTDDETESPRSKKRRKTAKANSKRNSKSTGSDDEADDVESDEDDDTCSQAATNAPKPLSESLAATKILTPADFARLNELKISAIEEAAKAAGSKNANSVHQKLLKELRKRAYHDPQGLTTFDGDLAGAGGQQAHVTEGDIIGKQKKAKQDYEERMASIQAGRQGREKFGSSKVRGRKGLKNGATGSSTNEAKSRQKAFAMTQNSNKVRSKKGASLRDRQKVLRAHIDRKKRGGRRGNN
The following text describes a protein:
Function:
Plays a role in metal homeostasis. Confers tolerance to high zinc (Zn) and nickel (Ni).
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Subcellular Localization:
Nucleus.
Sequence:
MCALVPPLYPNFGWPCGDHSFYETDDVSNTFLDFPLPDLTVTHENVSSENNRTLLDNPVVMKKLNHNASERERRKKINTMFSSLRSCLPPTNQTKKLSVSATVSQALKYIPELQEQVKKLMKKKEELSFQISGQRDLVYTDQNSKSEEGVTSYASTVSSTRLSETEVMVQISSLQTEKCSFGNVLSGVEEDGLVLVGASSSRSHGERLFYSMHLQIKNGQVNSEELGDRLLYLYEKCGHSFT
The following text describes a protein:
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Sequence:
MPQQPVSKKPPPLAPIPIQILRHEPIEPNPISSPHAISHLSFISFFFTDNKDPIDRSPAAANSPAGLEMKVDREMEILLNEIPLLHHGGLLGGSGEAGADDDADLSFLIHELAAMGVVDGDDEPPAPGAANGFGFSSMMIYPKKGGENLVSLHPFSMAGHCAHMPSLFDPVTFAAADGWDIRCSPPPSVSVSPPPATPRARCKNVRRKNGGCGAVTATSPKKCGAAAAAAAAAANKSHGESLAGLRGVMSHIARDQHGCRLLQQRLDDGKREVDHIFAGVSRHAAQLMVDPFGNYLMQKLLAVCDAGQRMALVLTLTADAFVLVRISLNVHGTRAVQKLIESLRTREEISLVIDALRPGFLELIKDPNGNHVVQKCLQAFEADDNKAIFDAAALHCLDIGMQCHGCCVLQRCIARSRGEHRDKLVAAIAGNGFKLAQDAYGNYVVQYVIDLKIPNANSSLAQQFEGKYIHLSMQKFSSNVVEKCLKVFKEVDKAKIILEILATPHLEQLLQHPYANYVIYSALQNSKGSLHSALTNAIRPHVELLRTSPYCKRIYSRALLKK
The following text describes a protein:
Function:
An efflux transporter able to transport Hoechst 33342, ethidium bromide, doxorubicin and a number of other drugs in vitro into inside out vesicles. The endogenous substrate is unknown. It has been suggested that NBD dimerization induced by ATP-binding causes a large conformational change responsible for substrate translocation. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
In BmrA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. This is considered to be a half-size transporter that undergoes homodimerization to be functional.
Sequence:
MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSLLIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLRELLWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILFIMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKASNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSGELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQIENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYSPTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEKAAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSSLDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMASHGLYRDFAEQQLKMNADLENKAG
The following text describes a protein:
Function:
Probable phosphomutase that may have a function related to the manipulation of phosphate groups on carbohydrates. Reduces trehalose-6-phosphate levels when overexpressed in TPS2-deleted cells. Reduces 5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR) levels, a metabolic intermediate at the crossroads between AMP and histidine biosynthesis pathways, when overexpressed in a ADE3-ADE16-ADE17 triple deletant.
Miscellaneous:
MISCELLANEOUS: Present with 3250 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSLRAVPGYFAAYPSEGFQGLDSTKYDHLELINHKNWKELYHAIPRNTKNRHYKLLILARHGQGYHNAAILRYGMEKWDAYWSLLSGDEHGEWLDSKLTPLGKDQVRRTGSNVLLPMAKQLGMLPHVFFSSPMRRCLETFIESWTPVLAETQELPAGTKISTRIIEGLRETLGSHTCDKRVAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNQLSSEEKFISLTCHSGVIQSVLRNLQHPPIYNLDTGKVVAVVVEVPVNTADRGRL
The following text describes a protein:
Function:
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Subcellular Localization:
Cytoplasmic vesicle. Golgi apparatus.
Sequence:
MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNAAVERQKHLEIERTTKWLKMLKGWEKYKHTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIEQLQISMAELKRAKLDLPEPGKEDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQSRTGTPERAQPARRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIRKEFVPKWNKPSDVSATERTAKYTMEGKGRAAHPTLAVTVPGPAEVRVSNVRPKMKALDAEDGKRGSTASQYDNVPGPELDSGASVEEALERTYSQSPRHALYPPSPRKHAEPSSSPSKVSNKFTFKVQPPSHARYPSQLDGEARGLAHPPSYSSPPVYHGNSPKHFPTANSSFASPQFSPGTQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNGKLIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAVSVDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MLDHVLLLTYCLVSTVVRSQPSADVFRSFAGYIPEDHRVTHHEWQNSGKFQGDIDGVDPNLLKLPEGPVLFNALKNKQLTWEGGVIPYEMDTAFSPNEIKILEKAFDSYRRTTCIRFEKREGQTDYLNIVKGYGCYSQVGRTGGKQEISLGRGCFFHEIIVHELMHSVGFWHEHSRADRDDHIKINWDNILPGMKSQFDKISAVLQDLQGENYDYKSIMHYDSTAFSRNGRNTIETVENGFTQVIGTAMDLSPLDIVKINKLYSCKTKKKEKVKPATTEEPHQLIPQVVDKNSVDSGEKCVDHFADCPHFAQYCTRASFFFVMKSYCPFTCKHCPGDRKLKKSG
The following text describes a protein:
Function:
Amino acid transporter involved in vacuolar uptake of basic amino acids for storage during nitrogen replete condititions. May function as an amino acid/proton antiporter.
Miscellaneous:
MISCELLANEOUS: Present with 1420 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein. Note=Localizes to the vacuolar membrane both under nitrogen replete and deplete conditions.
Sequence:
MGRTIRRRRSNSSLSEAISVSLGINQDSSVNKMHRASVSAMSPPLCRSYMSGFFTGGNSPMINNLSDSKLPISNKQHPKVIHGSENLHRQTAQLSNEFCSSSVEENSPTIKDYMDIIGNGDRKDDQSMRTIEENIDEEYSDEYSRLLLSPASSNVDDDRNRGLQNSSLPELEDGYAGGYQSLRPSHNLRFRPRNLWHMCTSFPSKFAHYLPAAVLGLLLNILDALSYGMIIFPITEPVFSHLGPTGISMFYISTIISQAVYSGGWSSFPSGIGSEMIEITPFYHTMALAIKEALAGNDDEIITTTIFCYVISSMLTGVVFYALGKLRLGKIVGFFPRHILIGCIGGVGYFLIITGIEVTTRVAKFEYSWPFFSGLFTDYDTLAKWLLPVLLTVVLIGTQRYFKNSLVLPSFYILTLVLFHFIVAIIPTLSLDALRQAGWIFPIANSDSKWYDHYRLFNVHKVHWSLVLQQIPTMMALTFFGILHVPINVPALAMSLQMDKYDVDRELIAHGYSNFFSGLLGSVQNYLVYTNSVLFIRAGADSPFAGFLLIALTICIMIIGPVIISFIPICIVGSLIFLLGYELLVEALVDTWNKLNRFEYLTVVIIVFTMGIFDFVLGIIVGILIACFSFLVDSTKLQTINGEYNGNVARSTVYRDYVQTKFLDGIGEQIYVLKLQNLLFFGTIISIEEKIERLLQISNKDATKRRIKYLILDFKNINADNIDYSAAEGFNRIKRFTETKRIKLIISSIKERDRIYNAFNNVGLLNDVELFADLNSALEWCENEFLFQYKQLRKKAKERLEEGKQNNVVSAVIAATKNKKIDTIGNGLNRGSNGDTARNLMSLPTNTPRNYQILSVAQNVFVNDEQAVKNFKKEYKDDEPVLPILLFALKQYRPDIISEVQKVREKEIKFWAQLCPYFTRRRLASQSHLLHADNIFFLVETGMLKATYELPQGTLYEIFSNGTCFGKIIAPGNAMPREQKLTIETETDSVLWVIDSSSLNKLKEDNLALYVEVALMVMCIKDTRFKELLGYTLVSA
The following text describes a protein:
Function:
Plays a role in the establishment of transcriptional silencing boundaries, preventing the propagation of heterochromatic silencing.
Miscellaneous:
MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
Sequence:
MIENKVELVAELVLESIGKTEVVSRHTEGTKSCQVSFRIKDSPSEKGSTSFLSELVVIQTLDDNDKYTVVIRHGTSITMACVVGYSDFKLPTELKWPLERESLPVEPDLKPIMTQLKRQTAGSADMPKFDDEYQAQARQNQGTAPLNPYPGLTVTEPSFANPAGGYADGDLYPVGTSHPDWSGGLPNPLGNPSSQGGMIFDPNRRPAPRREDMPPGWMPGSKYDEPFGPGSGGFGGSGSGGFGGSGSGFI
The following text describes a protein:
Function:
Involved in the uptake of non-siderophore sources of iron and the siderophores ferrioxamine B and ferrichrome. Has a role in the retention of iron in the cell wall and periplasmic space.
Subcellular Localization:
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Domain:
The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
Sequence:
MKLSSAFVLSAITVAALGESITTTITATKNGHVYTKTVTQDATFVWAGEGAAVTSAVTEASTVAATSAAAETSVAAETSIVEPSTSAQGTSADEGSGSSITTTITATKNGHVYTKTVTQDATFVWTGEGERAPASTVATVETSVAAETSVAEPSTSAQGTSADEGSGSSITTTITATKNGHVYTKTVTQDATFVWTGEGERAPVSTVATVETAASPVTSVAEPSASTDEGSGSSITTTITATKNGHVYTKTVTQDATFVWTGEGERAPASTVATSSISAIEIPSTTEASIVEASSAVETSSAAETSSAVETSSAVETSSAVETSSAAETSSAAETSSAVETSSAVEISSAVETSAVETSSSSSTIETTSVKSLSPTQTSLSSSVQASSPIETSSAAKTSSVVPTFSSTTTENSSNSKSTSAVVASTTTSSESSATIVTPTRIGQAYTESSSRDAQSVRTHESNNWSSSSSASTKMVSSITRVQTTTAGIFTNGKSSTTPQIVNYTGAADSIAAGTGLMGAALAAVIFL
The following text describes a protein:
Function:
SAM-utilizing methyltransferase involved in nod factor synthesis.
Sequence:
MTQDENHQLLERELAVDDPWRLDTSAFEQQRYAQMLRMSRRDGDAASALEVGCAAGAFTEMLAPLCERLTVVDVMPQAIERTRLRTGKWSHISWVTCDIQRFSTTEQFDLIVVAEVLYYLRDVVEMHAAIRNLVSMLAPDETLIFGSARDEICQRWGHAAGAETVIALFNESLSEIERRHCCTGSASEDCLIVRFLKPGGASAQSNAGH
The following text describes a protein:
Function:
Binds to 23S rRNA.
Sequence:
MDGIKYAVFTEKSLRLLGKNQYTFNVESGFTKTEIKHWVELFFGVKVVAVNSH
The following text describes a protein:
Function:
Probable transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondrial morphology, which is balanced between fusion and fission (By similarity).
Subcellular Localization:
Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence:
MEKSARQLSVAEQNGESGRLNNGYTSNNIQQYKDETNRHQFEYNQNRNQLLRSIHIIQNLLNELDNYVDRSDCLFHSVWRTDKEKSKFSGNYYPFSPSKMNVITIDLSLRSSSTADEKLISQLGEEAHESLLKVHIEKANKHLFSLFSRVEDTSSKILITGDLNAGKSTLCNALVHKDILPEDQQPCTEVFCEVHDAELNDGKDCVHAIPHGLTYSHTDSSTYKVFPIEDLKRLVYETENWSMLIVYVNDGRPAHESLLHNGITDIALIDAPGLNTDSMKTTSVFACQEEIDVVVFVVNAENHFTLSATDFLRNASTEKSHIFIIVNKFDNIRDKERCKRLILEQIHTLSPGTFADAKDLVHFVSCRVARDPNNREDALYSSFFQMENSLRSFILENRSKSKLAPVRRYLSGLVGDILNICEYNIKLIDFDINHLQQRLTDLSPKFRKVKHEQQFTYQKNESLVEATVQSISQHTHSELEDAIDSLGSFASVKYSGFFFAYQYAISVRDAMQQYLEEKLLESEDYARKRTEEAVLCIQKDVKDNFDSAVLPVFHANQMFIKKHRLQLQKHFRFELGLLDFIDLDLTERLGTWSASLSTILLVLGKTTPSFTTLGAFTGNLGYPIFKYFQNNSLQHLLVPVLGLASICVFGYVIYDIPRALPLKVAEKIKKSLRETDFCHNASIWIGTESRKVLNIPLNDLRRMFHQQWDKQRETISVAENDLRICQKARKFFGEIESRTREAKKKIMMVQLEGCDINY
The following text describes a protein:
Function:
Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.
Subcellular Localization:
Peroxisome.
Sequence:
MTEANTKTQTQLDSEHFSPYRADGKLPVGKAIVTELAEPYSELADAVNAQFPNTKVIGYPYNITSEEATLALIDDVLNSWGRLDIWTSSTSHLGPPSIQSTSPNDLLNAFETNAMPAFFALKYAPAAMQKTTPKGSYPNAAPKDAPYGSIIVVTSVAGTYGGCWSPAFSMASHAALGCVRSGVLVLKGTGVRINAIAAGQIDVGVDLAGGEDMEKGQFPPAQLQGEDAQRRLIGLERAGRPEEVARAVGFLASGFSSYITGSEIRVDGGAGVMNPIMVPV