lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for proper chromosome segregation during mitosis and error-free mitotic progression.
Subcellular Localization:
Chromosome. Nucleus, nucleolus.
Sequence:
MDTPLRRSRRLGGLRPESPESLTSVSRTRRALVEFESNPEETREPGSPPSVQRAGLGSPERPPKTSPGSPRLQQDAGLESPQGQPEPGAASPQRQQDLHLESPQRQPEYSPESPRCQPKPSEEAPKCSQDQGVLASELAQSKEELTPGAPQHQLPPVPGSPEPYPGQQAPGPEPSQPLLELTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKRKGSSSQALASKTLNKEELPVIPKGKPKSGRVWKDRSKKRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHLEEEKERRRQEKKQRRAENLKRRLENERKAEVVQVIRNPAKLKRAKKKQLRSIEKRDTLALLQKQPPQQPAAKI
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Subcellular Localization:
Cytoplasm.
Sequence:
MSARSRSSSPEFDPLAFDQDFTPLPEYKAPTDTALDFGGLLPEPLKLHEDLKTGCGGQLWPAGMTLAKHMLRYHGDKLQKARILEIGAGGGLVGLAVAKGCSFETPMYITDQLEMEELMAYNTTLNGLNDKVKSMILNWGEPLPEEIVALKPDTILAADCVYFEPAFPLLLQTLKDLLALEPSATVYFCFKKRRRADMQFLKAARKTFKITELEDQDRPVFSREGLFLYAFTRK
The following text describes a protein:
Function:
Putative thioesterase. Does not bind pectin, and has no pectinesterase activity.
Subcellular Localization:
Cell outer membrane; Lipid-anchor.
Sequence:
MNTFSVSRLALALAFGVTLTACSSTPPDQRPSDQTAPGTSSRPILSAKEAQNFDAQHYFASLTPGAAAWNPSPITLPAQPDFVVGPAGTQGVTHTTIQAAVDAAIIKRTNKRQYIAVMPGEYQGTVYVPAAPGGITLYGTGEKPIDVKIGLSLDGGMSPADWRHDVNPRGKYMPGKPAWYMYDSCQSKRSDSIGVLCSAVFWSQNNGLQLQNLTIENTLGDSVDAGNHPAVALRTDGDQVQINNVNILGRQNTFFVTNSGVQNRLETNRQPRTLVTNSYIEGDVDIVSGRGAVVFDNTEFRVVNSRTQQEAYVFAPATLSNIYYGFLAVNSRFNAFGDGVAQLGRSLDVDANTNGQVVIRDSAINEGFNTAKPWADAVISNRPFAGNTGSVDDNDEIQRNLNDTNYNRMWEYNNRGVGSKVVAEAKK
The following text describes a protein:
Function:
The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules.
Miscellaneous:
MISCELLANEOUS: Transcription is induced by mei4 transcription factor.
Subcellular Localization:
Nucleus. Chromosome, centromere. Note=Localizes to the central core of the centromere.
Sequence:
MSTISTSTDSKLDNLGLSVTSRRNQILFYLSKALNLAHLLRSDSLQKSFLDALKQSATDSELLHKNLDEIKFLQNEKLNNEKLLEQEQNEANDYRLKVERLEHKISDYVQEINSLNSQLQIQKSNPEKHEDAVSQNRLRGSLDTVSSPSKTHKANKDEKATRLHLIIANLKKALKEKDAEVLNLQSHVSSKESELDRFKIKLETEESNWKVRLQVLESKLATQDRKLRMQKKSTERKSLLVSPRVSSPKLFSPSKQAIMGTRQPNATSGSPLSVTPFLQKTSTSIGLSSSPPQSSPSAQSSQPFSRDKYPHSMTVSPSNARYLKKHLDDTIPSNVSDINHNDHLKIPQSPSSLSPSKIPIRKKRKLKDTVSNCEFTEEDSESSFLLETIQPTKSTLRRSISPLKKRNDEINELKKGFTMKK
The following text describes a protein:
Function:
Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MGKDSKKHKKERRRERSPSTSDSDEERLQKRLAEQRSLKKDEKRRQKEEMKKNESAEEKRARRMEKKMRKDAKRKDADAEDTLIPPELNYTNLNNPFNDTKLTQTFVWGKKLEREGKSGLTQDEITKQTSQRIRKNLHEAAEFKRIRDSRAAAKEDMEMMKRDADLRAGQISDTKEREFQMDQIKERTRIRIDQGRAKAIDLLSRYARFADENPHTAKIPDFELENPMEYLKASCKSVDDYEDLIEDIKTYREVDGWAKNETWWMDVTRIAEDEIQKKAAQNRGDVHASVQTEVQNMFKNKSIDELLKLEDQMDAKIRGNSGNKGYWQDLDDQLKVFIARKRLREHHGRVLRLQLAIIKEEQKKEIQQQESEELLPVAEVPPQVKIQKEEEEEEEEDEDDEKISKKVRRKIDVQTLDDPELDEPERERKWRALTGDQLDDVTRELYRIGCYSPTYISADDTMPGIEILDEQADVDNLTERRNRNRGTLPSSSAASSGAPQGASSKMMAIAREGMEADESIFGAEEQLAAQRHLWSDKYRPRKPTYLNRVQTGFDWNKYNQTHYDQDNPPPKIVQGYKFNIFYPDLLDMTVAPRFGLTSCEDPDFAIIRFKAGPPYEDIAFKVVNREWETLHKNGYKCQFQNGVFQLWFMFKKYRYRR
The following text describes a protein:
Function:
ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (By similarity). Involved in nucleotide excision repair (NER) of damaged DNA. XPB-R is a paralog of XBP, but is not a component of the TFIIH basal transcription factor and is dispensable for RNA polymerase II transcription.
Sequence:
MQCLFLEERIKKEGCVVLFAEAFRPSFANIQGFLTTIAEPVSRLSLMHEYRMTYFSLGAAASASISVSEVIQFLDDHVYFFRDKCFASYRESVCAFAEMYMSRCNLARVVIDESRTLLECKDIVTAKTLLKDRVVRSLCCQPKETVGEDACPHFLLKSRAAARVVAERCVLLGYPLQQQYEYEKDTSIRNVNIALKSQTRPRPYQIAAVDAAASDGALRSGCIVLPCGSGKTLVGIMLLCKVKKPTLILCAGGVSVEQWRNQILEFASVCAPANNEEGDPSNSTTGEKVRTAAVGAARISCLTGKQKDEITDETDIVLTTYSMLVTAHKAQARCQVEGFEMNADGRGRNPRRANPKERLFQPYGLLIMDEVHMMPADAYKDSLGFINAKGVVGLTATYVREDSKIRDLFHLVGPKLFDISWERLASSGYLAHVTCIEVLTPLARRFSLEYLERSSELTSPQHGTPLLVMLAAANPNKMLCVMEIVKRHVAESSKILVFCDHIMLLKEYSKLLGAPVVCGDTPHRERLMIFSDFQSTSKVNVVCLSRVGDVSVNLPSANVVVQVSSHGGSRRQEAQRLGRILRPKEKASNGKPTDAWFYTVISTDTVEMSYAAHRTAFLVDQGYTCSVTEFNPDGAPEAAVEGVDDTAPGDVVSIRQAKLRGTFKKQELKCSVASPTAQGSVNPRSLDYQEKLLCRVVASWELDYQNATSQQNEPGVANDTATGLIDKKMKRARDETAEDIKREWNSGAQTTQPRGDFCRLPLQRLVGANDDVVYHES
The following text describes a protein:
Function:
Has a role in meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MSEEDNRLNELFANDLGVQPPCERSLKEGRRFLNDFEIAAKKKLLELERKALEDKEKNLNFVVESERTLFNSKKRAFDNDECYNDRCKLFRGIVNEWGRSERTLDSLDEPPAWFRREMGEWKKAREEDKAEWKKAREEDKAEWKKAREEDKAEWKKAREEDKAEWKKAREEDKAEWKKAREEDKEWRNSMDEWRKSMDEWRKSMDEWRKSMDEWRKSTDEWRKSTDERLENLLNIVREILDVQRDMRNDLSNLTRKVDRMDMRLSRNNNMIMRSFAQPITEVPFFNGDIPDPNLPRITRIEDIDSLSEENCTRYLKGYGVSYDENDQSLWKRQLAKAVGLTAAYDESYTFSPFSSSE
The following text describes a protein:
Function:
Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins. Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair pathway by interacting with FANCI component and subsequently mediating the formation of FANCI homodimers. Also plays a protective role against ER stress-induced apoptosis.
Sequence:
MIEVVCNDRLGKKVLVKCNTDDTIGDLKKLIAAQTGTHWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ
The following text describes a protein:
Function:
Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Required for faithful chromosome segregation during mitosis.
Subcellular Localization:
Lateral cell membrane. Apical cell membrane. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm, cytoskeleton. Note=Colocalized with microtubules at the base of cilia. Gradually accumulates on the apicobasal microtubule bundles during epithelial cell polarization (By similarity). Colocalized with the apicobasal microtubule bundles running beneath the lateral membrane. Colocalized with microtubule bundles in the spindle pole in mitotic cells and in the midbodies at the end of cytokinesis.
Sequence:
METLNGPAGGGAPDAKLQPPGQHHRHHHLHPVAERRRLHRAPSPARPFLKDLHARPAAPGPAVPSSGRAPAPAAPRSPNLAGKAPPSPGSLAAPGRLSRRSGGVPGAKDKPPPGAGARAAGGAKAALGSRRAARVAPAEPLSRAGKPPGAEPPSAAAKGRKAKRGSRAPPARTVGPPTPAARIPAVTLAVTSVAGSPARCSRISHTDSSSDLSDCPSEPLSDEQRLLPAASSDAESGTGSSDREPPRGAPTPSPAARGAPPGSPEPPALLAAPLAAGACPGGRSIPSGVSGGFAGPGVAEDVRGRSPPERPVPGTPKEPSLGEQSRLVPAAEEEELLREMEELRSENDYLKDELDELRAEMEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLEMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRLMDISPFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPNRGHNGGGPDLWADRTEVGRAGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGLRVLHSPPAVRRVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYVEGARRPLDSPLCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMACQTNGSRTMGTQTVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLRSRQVAPAIEKVQAKFERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSESAWARSTTTRESPVHTTINDGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGPGQETGTNSRGRSPSPIGVGSEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSDSHSLGDTAEPGPMENQTVLLTAPWGL
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol and 2-heptanone.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEKLRSYEDFIFMANMMFKTLGYDLFHTPKPWWRYLLVRGYFVLCTISNFYEASMVTTRIIEWESLAGSPSKIMRQGLHFFYMLSSQLKFITFMINRKRLLQLSHRLKELYPHKEQNQRKYEVNKYYLSCSTRNVLYVYYFVMVVMALEPLVQSCIMYLIGFGKADFTYKRIFPTRLTFDSEKPLGYVLAYVIDFTYSQFIVNVSLGTDLWMMCVSSQISMHLGYLANMLASIRPSPETEQQDCDFLASIIKRHQLMIRLQKDVNYVFGLLLASNLFTTSCLLCCMAYYTVVEGFNWEGISYMMLFASVAAQFYVVSSHGQMLIDLSTNLAKAAFESKWYEGSLRYKKEILILMAQAQRPLEISARGVIIISLDTFKILMTITYRFFAVIRQTVEK
The following text describes a protein:
Function:
Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSATEEENVLVFDTTMKKKKKSKDSAAQTEEEKKKLKSKTLAMMSQQEDEQEQEDEKKEKRKKKKAALLASTEGENSEAIEKLENEGAHDEDIEAEFMGEKKKKKKSSKSSTTTTTSTTTTTTEPTETEPTEDGESKEKTITTSDGDTFVQGTIPWAGTDRDYKYSELTYRIYHLLQANNPDLISDQKRTMKPPQVMREGTKKTIWANFAEICGTLNRKVEHVYNYVFAELGTNGSIDGNQRLVIRGRFKTSQIEIVIRHYISEYVACRNCKSPNTVLERNNRLYFLCCNACNSKRSVAVIKKGLEGAGKKAPKEQS
The following text describes a protein:
Function:
Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
Subcellular Localization:
Lysosome.
Sequence:
MSAVVLVLFTIGAFISPVRSLDNGLALKPTMGWLHWERFMCNVDCDTDPNNCISENLYMQMADVMVTEGWKEAGYEYVCIDDCWPSHQRDAKGRLQADPKRFPRGIKKLADYVHSKGLKLGIYADLGTFTCGGFPGSLGYYDIDAQTFADWGVDLLKFDGCYMKWTLLGEGYTNMSIALNQTGRSILYSCEWPLYEWPYHQPDYAAIRKACNHWRNFADVYDSWDSVKTILDWTADHQDVIVPAAGPGGWNDPDMLVIGNFGLSHTQQESQMALWAIMAAPLLMSNDLRDICPRSKQLLQNTRIIAISQDPLGRQGYRTAKVDSFEVWERHLSGGRLALAVMNKQEIGGPRGFPLTLATLPSWKICHPQCNVTQVLPSYKELGVQTLLSELVVVVNPSGTALLTVTPI
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MNHQVAADEMVLISQYYPDIYTQLVPQQGESKPRRRRKKKQGEGSGSGIMRKRKLSDEQVNLLEQSFGSEHKLESERKDKLASELGLDPRQVAVWFQNRRARWKSKKLEEEYSKLKSDHDTNVVEKCRLESEVLKLKDQLSEAEKEIQRLLLERCDGVSSNTSPSTSSFSMEAAMEPPFLGEFGMEGLDNVFYTPDNTYVQGLDWVNLYI
The following text describes a protein:
Function:
Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. Probably undergoes several conformational states in order to translocate the substrate across the membrane; keeps the substrate accessible to only 1 side of the membrane at a time by opening and closing 3 membrane-internal gates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSSQGNESPALVRAVSRWQIVGLSINDVIGSGIYLLPAATAALLGPMSLWAVMLAGLAVALLVLCYAQAASYFDTPGGSYLYTREAFGPFTGFQIGWMIWLTRISSAAALSNGLADAVARFWPAAGSDGWERLLVVVGSLGLLTAINVIGVKSAARTGVALVIGKLVPLLLFVAIGLFYVDWSWAFAGSTPDLRDLGNLGEAALLLLFAYAGFENIPAAAGEYRNPRRDVPFALITMIVTVTLIYAAVQVVAQGTLPNLAASPTPLADAASRFGGEALALILTVGATISILGTTSNTVMLGPRFLFALAQDGYGPALLARVHPRFHTPAAAVLTQGVLSLALALSGSFTQLALLSMVTRLFAYIGTAAAVIVLARRYRARTDALRLPGGPLIPIAALLLSLGLLASASWQNLAAAGLALLVGCVFYLFPRKPA
The following text describes a protein:
Function:
Digests cleaved signal peptides in vitro, its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Domain:
A tandem duplication in the protein fold creates an intact active site between the repeated domains of each monomer.
Sequence:
MRTLWRFIAGFFKWTWRLLNFVREMVLNLFFIFLVLVGVGIWMQVSGGDSKETASRGALLLDISGVIVDKPDSSQRFSKLSRQLLGASSDRLQENSLFDIVNTIRQAKDDRNITGIVMDLKNFAGGDQPSMQYIGKALKEFRDSGKPVYAVGENYSQGQYYLASFANKIWLSPQGVVDLHGFATNGLYYKSLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSRWIGELWQNYLNTVAANRQIPAEQVFPGAQGLLEGLTKTGGDTAKYALENKLVDALASSAEIEKALTKEFGWSKTDKNYRAISYYDYALKTPADTGDSIGVVFANGAIMDGEETQGNVGGDTTAAQIRDARLDPKVKAIVLRVNSPGGSVTASEVIRAELAAARAAGKPVVVSMGGMAASGGYWISTPANYIVANPSTLTGSIGIFGVITTVENSLDSIGVHTDGVSTSPLADVSITRALPPEAQLMMQLSIENGYKRFITLVADARHSTPEQIDKIAQGHVWTGQDAKANGLVDSLGDFDDAVAKAAELAKVKQWHLEYYVDEPTFFDKVMDNMSGSVRAMLPDAFQAMLPAPLASVASTVKSESDKLAAFNDPQNRYAFCLTCANMR
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MFSIGFCWLLAICGCTFAYIEIPEAYLTAIRQDRADEQAAGEYNYDEQGDDWTGTCQSGENQSPIDLIFEDSKIVAIPRLRFNNYDQPLQTPLVITNNGHTANMVIPQTRGGQRPSINGSLLPGNFEAQSVHFHWGSREAKGSEHAINFQRYDVEMHIVHKNTIYETMGEATMHPDGLAVLGVMFRAVDRQTSQHYGLNKIFNQLPRIVQYNSNATITGRLTVGQLLGNIVTGEFFTYNGSLTTPDCAEAVTWTVFPDVLDYPRRQITKLWNLRDSRQRPLINNYRSIQDTNSRDVYYRTIQ
The following text describes a protein:
Function:
Phenolic glucoside malonyltransferase that neutralizes phenolic glycosides in host plants. Catalyzes the transfer of a malonyl group from malonyl-CoA to the phenolic glycosides, leading to their detoxification. Phenolic glycosides, which are among the most abundant plant secondary metabolites, act as plant defense compounds: they strongly affect growth, development and behavior of insect herbivores. Has malonyltransferase activity against flavonoids kaempferol 3-O-glucoside, kaempferol 7-O-glucoside, isoquercetin (quercetin 3-O-beta-D-glucopyranoside), apigetrin (apigenin 7-O-beta-D-glucoside) and prunin (naringenin 7-O-beta-D-glucoside). Also has activity toward non-flavonoid rhaponticin, but with lower efficiency.
Miscellaneous:
MISCELLANEOUS: MAT1 protein-coding gene was acquired from plants through a plant-to-insect horizontal gene transfer event.
Sequence:
MSISSSVAVLNVVQVSPPTAPVNNAFQDRISLTHFDLLALRAPPNQRLFFYETHLPISAFAETVIPKLRDSLSLTLQNFRPLAGTLIWSLHSDEPYIRIKDDDSVPLTIAETDADPQKLFDDPFQQETDLQQLLPPLRVSETEASLLALQITLFPSGDICLGITFHHAAQDGASLALFLKSWAHICRHGDDPPLPQNLIPIFDRDFIDDPKNIKQLFLDHLLTPLTPGGPRNRSVKPMEKPFNDRMHGSFRLTVDDIENLRRRITSLQVQNTSQEPPVRMSTVVVTCAYVLTCFVKAGLTKKHVRFILPADLRKRLQPPVPDNYYGNCVFGCTVDMSSDDLAGQDGLVVAAKTISSVVSELDANDHRTFFENFLLNNTISQEETKVGVGGSIYFSLDEKDFGWGGPKHLKNVPPWPNHIYLAERRDGDKGVDFCLMLAKQEMAEFESKFLDDLKLLEKRSC
The following text describes a protein:
Function:
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.
Subcellular Localization:
Secreted.
Sequence:
MPIGIFPWVSTCKSEEMAFRAICVLVGAFVCSLCVKGSTQPQARVYLTFDELRETKTSEYFSLSHQPLDYRILLMDEDQDRIYVGSKDHVLSLNINNISQEPLSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQAFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNSRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSVYPVHRRPLLVRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPSNSSASGELILEELEVFKNRSPITTMKISSKKQQLYVSSNEGVSQVSLHRCDIYGTACADCCLARDPYCAWDGHACSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIATSQGLLIRAVQDSDQGLYHCIATENSFKQTVAKINLKVLDSEMVAVVTDKWSPWTWAGSVRALPFHPKDIMGAFSHSEMQMINQYCKDSRQQHQQGEESQKMRGDYGKLKALINSRKSRNRRNQLPES
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Subcellular Localization:
Chromosome. Note=Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers.
Domain:
The zinc finger domains (C2H2-type and C2HC-type zinc fingers) bind DNA and mediate recruitment to double-strand break sites. They show strong preference for DNA with 5'- or 3'-single-stranded overhangs, while they do not bind blunt-ended double-stranded DNA or poly(ADP-ribose) (PAR) polymers.
Sequence:
MSEELSAATSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFLTAMRESGIHCPLCRGSVTRRERACPERALDLENIMRRFSGSCRCCSKKIKFYRMRHHYKSCKKYQDEYGVSSVIPNFKISQDSVRSSNRSETSASDNTETYQEDTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNM
The following text describes a protein:
Function:
Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex (By similarity). Plays a role in microtubule-based retrograde axonal transport to promote neuroinvasion. Also plays a role in the inhibition of host immune response by acting as a viral deamidase. Deamidates host RIGI on two asparagines which becomes unable to sense viral dsRNA. In turn, its ability to trigger antiviral immune response and restrict viral replication is inhibited. Also deamidates a critical asparagine on host CGAS which abolishes cGAMP synthesis and downstream innate immune activation.
Subcellular Localization:
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus, host trans-Golgi network.
Sequence:
MADRGLPSEAPVVTTSPAGPPSDGPMQRLLASLAGLRQPPTPTAETANGADDPAFLATAKLRAAMAAFLLSGTAIAPADARDCWRPLLEHLCALHRAHGLPETALLAENLPGLLVHRLVVALPEAPDQAFREMEVIKDTILAVTGSDTSHALDSAGLRTAAALGPVRVRQCAVEWIDRWQTVTKSCLAMSPRTSIEALGETSLKMAPVPLGQPSANLTTPAYSLLFPAPFVQEGLRFLALVSNRVTLFSAHLQRIDDATLTPLTRALFTLALVDEYLTTPERGAVVPPPLLAQFQHTVREIDPAIMIPPLEANKMVRSREEVRVSTALSRVSPRSACAPPGTLMARVRTDVAVFDPDVPFLSSSALAVFQPAVSSLLQLGEQPSAGAQQRLLALLQQTWTLIQNTNSPSVVINTLIDAGFTPSHCTHYLSALEGFLAAGVPARTPTGHGLGEVQQLFGCIALAGSNVFGLAREYGYYANYVKTFRRVQGASEHTHGRLCEAVGLSGGVLSQTLARIMGPAVPTEHLASLRRALVGEFETAERRFSSGQPSLLRETALIWIDVYGQTHWDITPTTPATPLSALLPVGQPSHAPSVHLAAATQIRFPALEGIHPNVLADPGFVPYVLALVVGDALRATCSAAYLPRPVEFALRVLAWARDFGLGYLPTVEGHRTKLGALITLLEPAARGGLGPTMQMADNIEQLLRELYVISRGAVEQLRPLVQLQPPPPPEVGTSLLLISMYALAARGVLQDLAERADPLIRQLEDAIVLLRLHMRTLSAFFECRFESDGRRLYAVVGDTPDRLGPWPPEAMGDAVSQYCSMYHDAKRALVASLASLRSVITETTAHLGVCDELAAQVSHEDNVLAVVRREIHGFLSVVSGIHARASKLLSGDQVPGFCFMGQFLARWRRLSACYQAARAAAGPEPVAEFVQELHDTWKGLQTERAVVVAPLVSSADQRAAAIREVMAHAPEDAPPQSPAADRVVLTSRRDLGAWGDYSLGPLGQTTAVPDSVDLSRQGLAVTLSMDWLLMNELLRVTDGVFRASAFRPLAGPESPRDLEVRDAGNSLPAPMPMDAQKPEAYGHGPRQADREGAPHSNTPVEDDEMIPEDTVAPPTDLPLTSYQ
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence:
MPVPFEGLLPYAIMTAFFGLAGHGVQFIRYWDNGWKNDRYHLDEWDDKMMARDLLLTGVKRGQTSEAVAPESFKTAEKIEQRYWTPYRDEYFTLRERLFRGYAFGEWELS
The following text describes a protein:
Function:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MAPNSTPPPTFFGRIVFHLTSDDVFRTAIFAFIASFTVIAAVASVTGSFLVGLLASVIVLLVAYAVGESCEFINNQILMPAAFLGCAVAVNLVYTVAHEGELWEYFSRYFLFLSVFHFSEFVFTALTNRRTLGPDSFLLKHSFGYWLAASIGWIEFLIEANFYPEIKMYSVLWIGTFGCIIGEIVRKVGMVHAGLAFTHLMARTKRSGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNPISFVIYTFVTWRFFANRIEIEEKDLISFFGDDYAEYQRKTWSGVPFARGYQKP
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MFAVPGWSVSASALKKQSEPQPQTKASQSSKPEADSNANAKSNKRKRDDNVTKKNVDLMYRRHIEGSTAQAKATKPNSAKPKPEKKPWERKREEKNDAAKRDQDKDQAAKATETVVAGADGSAEEKKTVLTPLQQAMRQKLISSRFRHLNETLYTTPSTQALELFTSNPELFEEYHAGFSRQVKESWPSNPVDGYINAIRTRGAISPAPKKGSKPDQKSRGLALPRRPNGTCTIVDLGCGDAQLHRALLPSAKKLNLKLHSFDLHAPKDSPITKADISDLPLEDGSADIAIFCLSLMGTNWVSFVEEAWRVLRSDGKGECWVSEVKSRFGKTDISAFVEVFRTRGFVLKSETLDKSNKMFVKMEFVKAGGAPTKGKHVSASGAPGSGKKKFIEKTVAADNGMTPEEEAAVLKPCVYKIR
The following text describes a protein:
Function:
Molecular adapter that stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport. Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers.
Sequence:
MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETMYLRRPGGIERQYRKKCAKCGLPLFYQFQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAEREAKKAKMKGTLIDNQFK
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MDLSDKVMGSEEVITGLAMEIATPEVISSEIQVKAAEVISSEIQVKTPEVISSEIQQKTCVDCGAIKTPLWRSGPAGPKSLCNACGIRSRKKKRDLLGLNKDDKKTKKSSANSASSSGDSASSSNVEKKKKAPVKRADSISLHWSKLDEVERAAFLLMSLSCSSVRA