lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of malbrancheamide, a dichlorinated fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2.2.2]diazaoctane core. The first step of malbrancheamide biosynthesis involves coupling of L-proline and L-tryptophan by malG, a bimodular NRPS, to produce L-Pro-L-Trp aldehyde through reductive offloading. This compound undergoes spontaneous cyclization and dehydration to give a dienamine which is reverse prenylated at C-2 by malE. The other prenyltransferase present in the cluster, malB, displays modest activity, suggesting that may be a redundant gene in the pathway. Subsequently, a [4+2] Diels-Alder cyclo-addition catalyzed by the bifunctional enzyme malC forms the characteristic bicyclo[2.2.2]diazaoctane ring of premalbrancheamid. Finally, the flavin-dependent halogenase malA catalyzes the iterative dichlorination of the indole ring of premalbrancheamide to yield C-9 monochlorinated malbrancheamide B, C-8 monochlorinated isomalbrancheamide B, and dichlorinated malbrancheamide. MalA is also able to brominate premalbrancheamide at C-9 to yield malbrancheamide C, and, to a lesser extend, at C-8 to yield isomalbrancheamide C. Finally, malA can brominate C-9 monochlorinated malbrancheamide B at C-8 to yield malbrancheamide D, or C-8 monochlorinated isomalbrancheamide B at C-9 to produce isomalbrancheamide D.
Domain:
The very flexible region (621-646) acts as a substrate channel lid, having two main open/closed conformations.
Sequence:
MAPTPKYTFTERAAAGNLSDAEILNSNNPTGSELPDESDVVVGGAGIHGLIYALHASKYKPNNLKISVIEKNTRPGYKIGESTLPIFYTWCKLHGISAAYLLRLFGLKDGLCFYFLDRENQGQYTDFCSVGAPGLVLASLQIERPMSELLFTILAQRNGVNVYHGREVDFKSTVVQGGGQGNKIAVSRGKYDSTPKTIDSALFVDATGRFRQFCSKKAPRHRFDGWNCNAFWGYFTAPKDESKIPFDLYEGDHTNHLCFPEGWVWVIRLPSWEGSLIANLMDMVTYILECADAGVPGDELPSSEELARMFGLKFQWVTSIGFAVRNDVKYPEDLSAYGTREAEQKFNYFVQKYELLQQFMSNFELIENLYGPGTTWFIRKTLAYQSPVVSGPGWLAIGDACGFTNPLYSPGINVGMSTSTWAAQLSHRIVEIGKSAPADAAESSIRKLLVPYDDYCKSLVPALEQMNRFNYVCYRDTRLGPQVACLWQFFAGIERYLSDVNIETFAHYAIKWVWGAMVPEYQQVAQKCIEHIETVPLDERLPDAMVDELLAFSNRIKSAAVAADDFSLRWDAILRSFDRSLNFVEGKTSRDIYTRQCSGCGAWLQLRPDWKKCHSCGLLGTEPQTAVTFDPPLTAEEEALLYAAWNTAPKYDPSKELKLPTPTRPAA
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly (By similarity); Makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit; This protein is located close to the polypeptide exit tunnel, and interacts with the modified macrolide azithromycin, which blocks the tunnel.
Sequence:
MAQINVIGQNGGRTIELPLPEVNSGVLHEVVTWQLASRRRGTASTRTRAQVSKTGRKMYGQKGTGNARHGDRSVPTFVGGGVAFGPKPRSYDYTLPRQVRQLGLAMAIASRQEGGKLVAVDGFDIADAKTKNFISWAKQNGLDGTEKVLLVTDDENTRRAARNVSWVSVLPVAGVNVYDILRHDRLVIDAAALEIVEEEAGEEQQ
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSSSSSSFKPNPLSLSVPDPALDRWLRDSGYLDILDSSASASASASTSSSPSATTTTAAASSTSTLINPTSAAAAVLAFARTLASVLALNPFARLSTTDLAAPTPSWSLAFLGPPGAASYSWPPTSTQARLRVQENVRRYARNYAALSILVFACCLYHMHCHLPSSLIVALIAFICSQSLRLRNISATAGVSRYRMPMALLGMLAILIVWESVRYCRERWGLATRAPGVGQFLLHSAQIGEVSIANVFLHNKSLERKIEV
The following text describes a protein:
Function:
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MDMAVQQLTELPPVTMTFIGGVFTLGLLQFLGFASEIHYIFLWKGIVQRHEYWRFVTPFFYFGKLNIDLALRAYFLSRHPRMLEEGCYRHNVAEYAWIMLFAAANLLLIAVAFPKISPPFLGSSLLSAITYLWARRNEGVRVSLLGVFTFTAPYLPWVTLAMSYIANDEGPGRDHRGRPIKVSHHDEMHQEPGLSGRDKTLIFELIGMFIGHVIFFLEDVYPKFSGGSRPLAPPWVYVQRWLDNSREQTEDVYVEEHNTDYAAPAPTQRLTDSVSHSETPQAGTSTSAQPTHREGLVNRLGDGS
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in the SLT2 mitogen-activated (MAP) kinase signaling pathway that regulates cell wall integrity. May also be involved in the mating pheromone and the CWI MAPK pathways.
Sequence:
MATDTERCIFRAFGQDFILNKHFHLTGKIGRGSHSLICSSTYTESNEETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHPNIVWLFDTDIVFYPNGALNGVYLYEELMECDLSQIIRSEQRLEDAHFQSFIYQILCALKYIHSANVLHCDLKPKNLLVNSDCQLKICNFGLSCSYSENHKVNDGFIKGYITSIWYKAPEILLNYQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEETLQEIASQKVYNYIFQFGNIPGRSFESILPGANPEALELLKKMLEFDPKKRITVEDALEHPYLSMWHDIDEEFSCQKTFRFEFEHIESMAELGNEVIKEVFDFRKVVRKHPISGDSPSSSLSLEDAIPQEVVQVHPSRKVLPSYSPEFSYVSQLPSLTTTQPYQNLMGISSNSFQGVN
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MGKRKAKAKPPPKKRMDKLDTVFSCPFCNHGSSVECRLDMKNLIGEAICGICQESFSTTITGLFLWDVFGICDIDSE
The following text describes a protein:
Function:
Part of the ABC transporter complex YclNOPQ involved in uptake of ferric-petrobactin. Petrobactin is a photoreactive 3,4-catecholate siderophore produced by many members of the B.cereus group, including B.anthracis. Binds selectively iron-free and ferric petrobactin and the petrobactin precursor 3,4-dihydroxybenzoic acid (3,4-DHB).
Subcellular Localization:
Cell membrane; Lipid-anchor. Membrane raft; Lipid-anchor. Note=Also found in the extracellular protein fraction. May exist in both membrane-tethered and soluble form (Probable). Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Sequence:
MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLDKNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGSLKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIGKIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHDVFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVKNVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK
The following text describes a protein:
Function:
Amino acid racemase that shows relatively high activity toward leucine, which is the preferred substrate, and methionine. Also exhibits lower levels of activity toward phenylalanine and alanine, and trace activities toward isoleucine and valine.
Sequence:
MTPEEVVERYSQVISRASHVTYVPIVPSRAENALVWDIEGRAYIDFLADAAVQNVGHNNPRVVEAVKKTADRLLHFTFIYGFPVEPLLLAEKLREIAPLEGAKVAFGLSGSDANDGAIKFARAYTGRRSIIGYLRSYYGSTYGAMSVTGLDFEVRSKVGQLSDVHFIPFPNCYRCPFGKEPGKCRMECVSFLKEKFEGEVHAEGTAALIAEAIQGDAGMVVPPENYFKKLKRILDEHGILLVVDEVQSGLGRTGKWFAIEHFGVEPEIITLAKPLGGGLPISAIVGRGEIMDSLPPLGHAFTMSGNPVASAAALAVIEEIEEKELLKRAQILGERAKRRLEKMKKKHELIGDVRGLGLMLGVDLVKDRETKERAYDEAKKVVWRAYELGLIVAFLQGNVLRIEPPLTIEEEVLDEGLDKLEEAIEDVEEGRVPDEVIEKVQGW
The following text describes a protein:
Function:
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Subcellular Localization:
Cytoplasm.
Sequence:
MTVNGADDVLLVHGGTPLEGEIRVRGAKNLVPKAMVAALLGSAPSRLRNVPDIRDVRVVRGLLQLHGVTVRPGEEPGELVLDPTHVESANVADIDAHAGSSRIPILFCGPLLHRLGHAFIPGLGGCDIGGRPIDFHFDVLRQFGAKIEKRADGQYLEAPQRLRGTKINLPYPSVGATEQVLLTAVLAEGVTELSNAAVEPEIEDLICVLQKMGAIIAMDTDRTIRVTGVDELGGYTHRALSDRLEAASWASAALATEGNVYVRGAQQRSMMTFLNTFRKVGGAFEIDDEGIRFWHPGGRLKSIALETDVHPGFQTDWQQPLVVALTQATGLSIVHETVYESRLGFTSALNQMGAHIQLYRECLGGSDCRFGQRNFLHSAVVSGPTKLEGADLVIPDLRGGFSYLIAALAAQGTSRVHGIDLINRGYENFMDKLVELGAKVELPGKALG
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Subcellular Localization:
Nucleus.
Sequence:
DDEDNAATEKAEPDFKLSGNLAKDTNTYKGVVIKYSEPPEARQPKTRWRLYVFKEDQSLPTVYIHRQSAFLLGRDRRVADIPIDHPSCSSQHAVIQYRLVDVEKEDGTLGKKVKPYMIDLESTNGTYVNNNRIESSRYVELKEKDMVKFGYSSREYILLHENSQDQLDEPEAEENTDAQE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is involved in the biosynthesis of phosphatidylinositol mannosides (PIMs), probably via a role in the biosynthesis of phosphatidylinositol (PI), a PIM precursor, which is derived from phosphatidic acid.
Subcellular Localization:
Secreted, cell wall.
Sequence:
MSAGQLRRHEIGKVTALTNPLSGHGAAVKAAHGAIARLKHRGVDVVEIVGGDAHDARHLLAAAVAKGTDAVMVTGGDGVVSNALQVLAGTDIPLGIIPAGTGNDHAREFGLPTKNPKAAADIVVDGWTETIDLGRIQDDNGIEKWFGTVAATGFDSLVNDRANRMRWPHGRMRYYIAMLAELSRLRPLPFRLVLDGTEEIVADLTLADFGNTRSYGGGLLICPNADHSDGLLDITMAQSDSRTKLLRLFPTIFKGAHVELDEVSTTRAKTVHVECPGINVYADGDFACPLPAEISAVPAALQVLRPRHG
The following text describes a protein:
Function:
Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Note=Localizes to resolvable rings at the proximal end of centrioles. In mitotic cells, localizes to spindle microtubules during metaphase.
Sequence:
MLPLCSERELNELLARKEEEWRVLQAHRAQLQEAALQAAQNRLEETQGKLQRLQEDFVYNLQVLEERDRELERYDVEFTQARQREEAQQAEASELKIEVAKLKQDLTREARRVGELQHQHQLMLQEHRLELERVHSDKNSELAHQREQNERLEWELERKLKELDGELALQRQELLLEFESKMQRREHEFQLRADDMSNVVLTHELKIKLLNKELQALRDAGARAAESLQKAEAEHVELERKLQERARELQDLEAVKDARIKGLEKKLYSAQLAKKKAEETFRRKHEELDRQAREKDTVLAAVKRAHAEELQTLDAKVLELQFLCETLEGQLRRAECTRAEDAKEKNALTDKFREDAAALKAAWDAQITQMSKETVSKDFQIHTLQEEEMKLKAQVARFQQDIDRYKQQLSLAVERGQSLEREQVQLGLDWQRRCDDIERDQIQKSETLIEGLTKARDQVAAKLQETEKALRQQETLLKAVSLERDQAMETLRTHGLLPGQEAQVPPQQHEGEIRADSPSTEIQRLQEQNAGLRNAVSQMRREMEMLSGHLPPAQPEECSNADPDPKAGGDSTPPDYVLTLEAEMQNLKHKLKALEEQLQSTEEPVKTSVATADPHHGVHSSAAAADAALADQTSTALALRKLGDRVHLLNLLVTQLKRKLRQKPRELVPVQHEVPSEVDQVHLEVLELQKQVAELRKHLKVTPQGEPSSREQLQRQGVADRYPMGMEDQTESPTFPQEGAQPPQTIYVTHLQRKLKDAARKILSLRLEREQLLEMGNRLRAEQGHAKGKPTPCPGPPTSEPQDPQEVPERSLDRGPPLGQLQPYSTTQDPRHTKRRCASEYAGKSQPHSAQVGSKTNTPRGHKAEMASRPAQLSQKQHRIPTETWKPVYQKENRTPKLPQAHEVPEESDHRTHRSSSLASSSLQDIWRLLELGSSPSGVPSQDNSVAECPAPSRPSCFQKVNRSPVPIQKAFAVKGLKMEAQPKATPPRPSKSHPAKPTNCQQQRPSRIRNYNLKD
The following text describes a protein:
Function:
Performs a specialized role during sperm development and maturation.
Subcellular Localization:
Secreted.
Sequence:
MTKPLLLSLIFFIIPAALAVDVDQSKNEVKAQRYFGSISISNANVKQCVWFAMKEYNKGSEDKYLFLLDKTLHATLQITDRMEYHIDVQISRSNCRKPLNNTENCIPQKNPKLEKKLSCSFLVGALPWNGEFDLLSKECKDV
The following text describes a protein:
Function:
Secreted cytokine-like protein. Inhibits cell growth in vitro.
Subcellular Localization:
Secreted.
Sequence:
MKLTTTFLVLCVALLSDSGVAFFMDSLAKPAVEPVAALAPAAEAVAGAVPSLPLSHLAILRFILASMGIPLDPLIEGSRKCVTELGPEAVGAVKSLLGVLTMFG
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase.
Subcellular Localization:
Nucleus.
Sequence:
MDGVVSGAGVRALRDLHHGELIATIPKAACLTLLTTAARDAIARARLGGGLGLTVAVMYERSKGKGSKWYRYLKTLPCQESVPFLWSEEEIDGLLLGTELHKALKEDKLLMKEDWEENIAPLTKEDPLEFPAQDFTFESYLAAKSLVSSRSFEIDAEHGYGMVPLADLFNHKTDAEDVHFMLNASDSDDDDDNNGLIIDDGLANGDCREISSDKSVLEMVMVKDVAAGSEIFNTYGQLGNAALLHRYGFTEPNNPHDIVNLDMDCLLEVLLSRFQKKRVRKRGRVWRKAGFSGCESQGSEYFEISAAGKPQIELLLLLFVIQSPARDCEALEDAAAKVKGRVKKAAKALGWRKETHWGPHPTKKPRLESVESRLERWLLNSTVIDLLLLVIGKRDELYGITFGKEERALGECRQHTKELHAARLRIGERRILRDCKQELLNMKAKQC
The following text describes a protein:
Function:
Forms pores that allow passive diffusion of small molecules across the outer membrane.
Subcellular Localization:
Cell outer membrane; Multi-pass membrane protein.
Sequence:
MNKTLIALAVSAAAVATGAYADGINQSGDKAGSTVYSAKGTSLEVGGRAEARLSLKDGKAQDNSRVRLNFLGKAEINDSLYGVGFYEGEFTTNDQGKNASNNSLDNRYTYAGIGGTYGEVTYGKNDGALGVITDFTDIMSYHGNTAAEKIAVADRVDNMLAYKGQFGDLGVKASYRFADRNAVDAMGNVVTETNAAKYSDNGEDGYSLSAIYTFGDTGFNVGAGYADQDDQNEYMLAASYRMENLYFAGLFTDGELAKDVDYTGYELAAGYKLGQAAFTATYNNAETAKETSADNFAIDATYYFKPNFRSYISYQFNLLDSDKVGKVASEDELAIGLRYDF
The following text describes a protein:
Function:
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Subcellular Localization:
Secreted.
Sequence:
MFLKAVVLTLALVAVTGARAEVSADQVAMVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLEPYADQLRTQVNTQAEQLRRQLIPYTERMERVLRENADSLRASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLAFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPYAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQPQEQVQMLAPLES
The following text describes a protein:
Function:
Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
Sequence:
MNSFKEGEYVLIRFGEKKFLRKLLPKQSLSVKKSVLKFDEVIGKPEGVKINGFEVYRPTLEEIILLGFERKTQIIYPKDSFYIALKLNLNKEKRVLEFGTGSGALLAVLSEVAGEVWTFEAVEEFYKTAQKNLKKFNLGKNVKFFNVDFKDAEVPEGIFHAAFVDVREPWHYLEKVHKSLMEGAPVGFLLPTANQVIKLLESIENYFGNLEVVEILHRHYKTISERFRPEDQMVAHTAYLVFGRKLKT
The following text describes a protein:
Function:
Transcription factor. Plays a crucial role in tapetum development. Required for male fertility and pollen differentiation, especially during the post-meiotic transcriptional regulation of microspore development within the developing anther. Binds E-box regions in the AHL16/TEK promoter.
Subcellular Localization:
Nucleus.
Sequence:
MESNMQNLLEKLRPLVGARAWDYCVLWRLNEDQRFVKWMGCCCGGTELIAENGTEEFSYGGCRDVMFHHPRTKSCEFLSHLPASIPLDSGIYAETLLTNQTGWLSESSEPSFMQETICTRVLIPIPGGLVELFATRHVAEDQNVVDFVMGHCNMLMDDSVTINMMVADEVESKPYGMLSGDIQQKGSKEEDMMNLPSSYDISADQIRLNFLPQMSDYETQHLKMKSDYHHQALGYLPENGNKEMMGMNPFNTVEEDGIPVIGEPSLLVNEQQVVNDKDMNENGRVDSGSDCSDQIDDEDDPKYKKKSGKGSQAKNLMAERRRRKKLNDRLYALRSLVPRITKLDRASILGDAINYVKELQNEAKELQDELEENSETEDGSNRPQGGMSLNGTVVTGFHPGLSCNSNVPSVKQDVDLENSNDKGQEMEPQVDVAQLDGREFFVKVICEYKPGGFTRLMEALDSLGLEVTNANTTRYLSLVSNVFKVEKNDNEMVQAEHVRNSLLEITRNTSRGWQDDQMATGSMQNEKNEVDYQHYDDHQHHNGHHHPFDHQMNQSAHHHHHHQHINHYHNQ
The following text describes a protein:
Function:
In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.
Subcellular Localization:
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MSFPKTLNVPDKSSLLVPQTTKASATGPTTAVSYETASSEIRSIRESPYLPSSPVDSQQFDGRSIISTSGMSEYIADLNDLPSIRHDINPTSIKTGGTGSRSFKFSNCFQTLDSELSNMDFFTKYISISKGDDKAQFNNKLKHFFIFSSAGKPIYSMNGSDDIVIGYMGILTTIVSSFQENFNQELQVLELGQGLKIVAVNKSPIILISISKLSFETVESVHLQLDTLYCYLIGILSKSVIDKHFNNRLNYDLRRILSPLDFENLDELCLNLTYGIPNTSDRTQDSTFGLYTSQVLLPLSRESVKIRHTLRSKLNSIVNTNNEDVLFTILLSGNGKILNYLHPKQHNLPNKDLNMLLFIIHSLLKNQSQQDEDLWLPLCMPTFNDHGFLYVFVRQWQDLVLMLISGSKNSFDALKLSANEICTKLNNKQELAVKLINELSIPLSIEVPFVFKHFIYKDIRLNQFVMSELPTHEFSSFQFLKCYNELKVSQAKIIKHDNNLNYKKLTYLQDRDITGFMLMDKYYEFYCIIERSSEQETITSKKLIQISSQIIRWCKKNHARLFVTI
The following text describes a protein:
Function:
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MYRYNKVLDATLIALVSFHLVISPFTKVEESFNIQAIHDILKFGIFPLETIDNYDHKQFPGVVPRTFLGSLVVAGLAKPILLLSSAFGFEIEGYELQKLVRAVLGLVNVLMLIRLRDSINKITFSDKKSKRKGLIGFWYTTLLLSQFHLLYYSSRTLPNFIALPLVNFSLSKIIQGDLSGLTWLAFTGIVFRLEVGLFGLIIAIVSSLGFGQSNIFGNIIYLAMGTLLGGFTSFCIDSYFWGRPLIPEIDSFIFNIVQGKSTEWGTEPWDTYFKKYLFQLFRPPVILMLAIPGLINDPANDGTKFGDKKSVPHPARYSLRILFISSILFIAAMSFQPHKEWRFIVYTIPIFTLQAANGVTNICQKWGLSVLNKVLIFIIGANVIISSLLSLHMGYISSFNYPGGDALQFTNNYILENYKNETVSVHMDVPACMTGITRFGELDGKFASYDKSEQDFDITNYDIIITHNEVPNWELLHSSRVFDGISLRMFIQIFMAQRKDRSTIFNITKLILSEFAQGEFGTVHDMLRSTITTVEYLNVYKNVNKNPHMVQGVPETKIIDQEIDPEEIRQDVNEQIDKFESAVL
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Domain:
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Sequence:
MACMKLGSKSDAFQRQGQAWFCTTGLPSDIVVEVGEMSFHLHKFPLLSRSGVMERRIAEASKEGDDKCLIEISDLPGGDKTFELVAKFCYGVKLELTASNVVYLRCAAEHLEMTEEHGEGNLISQTETFFNQVVLKSWKDSIKALHSCDEVLEYADELNITKKCIESLAMRASTDPNLFGWPVVEHGGPMQSPGGSVLWNGISTGARPKHTSSDWWYEDASMLSFPLFKRLITVMESRGIREDIIAGSLTYYTRKHLPGLKRRRGGPESSGRFSTPLGSGNVLSEEEQKNLLEEIQELLRMQKGLVPTKFFVDMLRIAKILKASPDCIANLEKRIGMQLDQAALEDLVMPSFSHTMETLYDVDSVQRILDHFLGTDQIMPGGVGSPCSSVDDGNLIGSPQSITPMTAVAKLIDGYLAEVAPDVNLKLPKFQALAASIPEYARLLDDGLYRAIDIYLKHHPWLAETERENLCRLLDCQKLSLEACTHAAQNERLPLRIIVQVLFFEQLQLRTSVAGCFLVSDNLDGGSRQLRSGGYVGGPNEGGGGGGGWATAVRENQVLKVGMDSMRMRVCELEKECSNMRQEIEKLGKTTKGGGSASNGVGSKTWENVSKKLGFGFKLKSHQMCSAQEGSVSKSNNENVKIEKLKDVKERRGKHKKASSISSER
The following text describes a protein:
Function:
Responsible for the release of ribosomes from messenger RNA at the termination of chloroplastic protein biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MALLLRRGVALAARSFRAAAASSASTTVHRLPAGASLAGAGELAPAQLFFFENRRGFAKGKKSKDDRGDTVQAVPDIGPTVKSAATAQMDAAVIALSRELSKLRTGRATPGMLDHIMVENADVKVALNRIAVVSVLDAHTLSVMPYDPTSMKSIEHAIISSPLGINPTPDGNRIIAAIPPLTKENIQALCKVVTKSAEDFKQSIRRARQKALDTIKKSASSMPKDDVKRIEKEIEELTKKFIKSSDDMCKAKEKEISGN
The following text describes a protein:
Function:
Involved in the lipid remodeling steps of GPI-anchor maturation.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MKILYSFLMLFVVAFASLGDNLPEFQSCLYQCDCHVIPQSIFWSCPANCNYYCQQLITDQLESSNVPMVQFYGKWPFKRVLGVQEFFAMIFSIGNLYVNYKNLRIIYRQFKRNESEYKTMYVQYLILLIVTCIGWSFSVIFHFKDTTMSETLDYFGAFAIILCNLNAIVVRVFQLFKHRKKLIIWHTALVALYLYHVIRLKRNWDYSYNTLINIIVGVSAMILWCFHSWRVYRVYNQKRIIYNNSIQLLPYETKLLQKLSYVGMSLSSLIPLIPIFNNVMLLLGISLELNDFPPVARLVDAHALWHLVTIFPSIIWFDWNVWDIEMLKITNNSETKV
The following text describes a protein:
Function:
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
Subcellular Localization:
Cytoplasm.
Sequence:
MAEEKKTRTLEQIQDEIRSYLGEIEYLRSQVGVIDATITDLRTVDATLAYLKEKGKGKEIYIPLGSGVAIRGKIENPDDVIMDVGAGILVGATVDEARENIEKRIKALMDLRLALLRKIEEDTRKVNELLKELQEMQPEKRE
The following text describes a protein:
Function:
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Miscellaneous:
MISCELLANEOUS: A longer mRNA that is not produced by splicing has been shown to be transcribed in barley and maize; it can also be predicted for rice. It is not known if this mRNA is translated.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPTGLLTVPFLENVNKFQNPFRRPVATTVFLIGTAVALWLGIGATLPIEKSLTLGLF
The following text describes a protein:
Function:
May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence. May play a role in spermiogenesis and oogenesis.
Sequence:
MSSSVHNDTGPVQLPEERRFLSTSEAAALERELLDEYRFGQQQLVELCGHASAVAVTKVFPLPSLSRKQRTVLVVCGPEQNGAVGLACARHLRVFVSNRAVMWGTETGLGSCCLLPPSPNPCSPQEYQPSIFYPARSADALHRDLTTQCEKMDIPFLSFLPAEVRLIDDAYGLVVDAVLGPGVRLAEAGGPCARALATLKRLSIPLVSLDVPSGWDAEAGGDAKDTVQPDVLVSFAAPKSCAGRFSGRHHFVAGRFVPDDVRRKFGLHLPKYTGTDCVASL
The following text describes a protein:
Function:
Type VI secretion exported toxin that via to its DNase activity induces growth arrest and ultimately DNA degradation within target cell. The activity is initially neutralized by a cognate immunity protein Tsi7.
Sequence:
MANEVYANNMEISCKAANGKSIAAFPDVCFTPPQAPPTPLGVPIPYPNTGLSKDTTKGTRTIRITRKEVMLKNKSYYKTSYGDEPGRAPKKGIVTSKIKGKVYFTSWSMNVKFESKNVVRHLDLTTHNHASFPGNTPVWPYLDQATVDAGGGPCSNEVKKEKKDCADFKPHGSKDACAGLGAGKPSGKKTSNEADRLADKVAARKCLTARRCALQPYKPNSCCPQQTAHHLIEASALHDKGRGGKGSVPLKGISNYSENKAPCVCAEGVNQNVGTHGLMHTFQSAAAAKSRSGTLQLSNGSSISAKKTTYGTAKRQSMAAMGKVFPQSKCSKECLSAQLDNYHKQCGINARTPIKAVETGQTDVTAATQAIKTRNARLGATRSRVR
The following text describes a protein:
Function:
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MKKKALLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGSNKKGKNTQVVSKKKKK