lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool binds to host FBXO3 to target TFIIH subunit GTF2H1 for proteasomal degradation with the help of the linker protein SKP1. Removes FBXO3 isoform 1 from the nucleus. Forms nuclear amyloid-like filaments of about 12 nm in width that may sequester NSs binding partners, causing cell cycle arrest. Also aggragates in the cytosol as short fibrils late after host cell infection. Plays a role in cell morphology and/or motility, reduction of lamellipodia, cell spreading, and dissolution of adherens junctions.
Subcellular Localization:
Host nucleus. Host cytoplasm.
Domain:
The C-terminus disordered region is involved in multimerization, filament formation, but not nuclear localization. OmegaXaV motif is required for both nuclear filament formation and degradation of host GTF2H1. This motif also mediates FBXW11 binding.
Sequence:
MDYFPVISVDLQSGRRVVSVEYFRGDGPPRIPYSMVGPCCVFLMHHRPSHEVRLRFSDFYNVGEFPYRVGLGDFASNVAPPPAKPFQRLIDLIGHMTLSDFTRFPNLKEAISWPLGEPSLAFFDLSSTRVHRNDDIRRDQIATLAMRSCKITNDLEDSFVGLHRMIATEAILRGIDLCLLPGFDLMYEVAHVQCVRLLQAAKEDISNAVVPNSALIVLMEESLMLRSSLPSMMGRNNWIPVIPPIPDVEMESEEESDDDGFVEVD
The following text describes a protein:
Function:
Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane (By similarity). NAD(P)H dehydrogenase; more efficient on NADH.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Peroxisome.
Sequence:
MSFHSFYQRASSLFKAYPSTSKILLLSTFSGGGGVLVYSDSNPLKRILHADATLDSDGNPIRKKKVVVLGSGWSGYSFLSYLNNPNYDVQVVSPRNFFLFTPLLPSVTNGTVEARSIVEPIRGLMRKKGFEYKEAECVKIDASNKKIHCRSKEGSSLKGTTEFDMDYDILILAVGAKPNTFNTPGVEEHAYFLKEAEDALNIRHSVIDCFERASLPNLTEEERKKILHFVVVGGGPTGVEFSAELHDFLVQDVAKIYPKVQEFTKITLLEAGDHILNMFDKRITAFAEEKFQRDGIDLKTGSMVVGVTADEISTKERETGKIVSEPYGMVVWSTGIGSRPVIKDFMQQIGQGQRRVLATDEWLRVEGCDGVYALGDTATINQRRVMEDIAAIFNKADKGNTGTLKKKDFNSVVKDICQRYPQVELYLKKNKLKNIANLLKSANGEDTQVNIEKFKQALSEVDSQMKNLPATAQVASQQGKYLAKCFNKMEKCEKKPEGPLRFRGEGRHRFQPFRYRHFGSFAPLGGEQTAAELPGDWVSIGHSSQWLWYSVYASKLVSWRTRMLVISDWTRRFVFGRDSSSI
The following text describes a protein:
Function:
May be involved in the regulation of cellular proliferation and/or differentiation.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
Sequence:
MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNVSSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGICSKPMGDLLDQIFIHRDTIHCGKCYEKLF
The following text describes a protein:
Function:
Plays a major role in single RNA editing events in chloroplasts. Acts as a site-recognition transacting factor involved in the edition of the unique site (corresponding to cytidine-488) of rpoC1, which is a plastid-encoded subunit of the chloroplast DNA-directed RNA polymerase. May provide the catalytic activity for editing site conversion. Involved in leaf vasculature patterning.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAMLVTNLSSSSFCFFSSPHLQNQKEIRSGVRVRKYVIFNRASLRTVSDCVDSITTFDRSVTDANTQLRRFCESGNLENAVKLLCVSGKWDIDPRTLCSVLQLCADSKSLKDGKEVDNFIRGNGFVIDSNLGSKLSLMYTNCGDLKEASRVFDEVKIEKALFWNILMNELAKSGDFSGSIGLFKKMMSSGVEMDSYTFSCVSKSFSSLRSVHGGEQLHGFILKSGFGERNSVGNSLVAFYLKNQRVDSARKVFDEMTERDVISWNSIINGYVSNGLAEKGLSVFVQMLVSGIEIDLATIVSVFAGCADSRLISLGRAVHSIGVKACFSREDRFCNTLLDMYSKCGDLDSAKAVFREMSDRSVVSYTSMIAGYAREGLAGEAVKLFEEMEEEGISPDVYTVTAVLNCCARYRLLDEGKRVHEWIKENDLGFDIFVSNALMDMYAKCGSMQEAELVFSEMRVKDIISWNTIIGGYSKNCYANEALSLFNLLLEEKRFSPDERTVACVLPACASLSAFDKGREIHGYIMRNGYFSDRHVANSLVDMYAKCGALLLAHMLFDDIASKDLVSWTVMIAGYGMHGFGKEAIALFNQMRQAGIEADEISFVSLLYACSHSGLVDEGWRFFNIMRHECKIEPTVEHYACIVDMLARTGDLIKAYRFIENMPIPPDATIWGALLCGCRIHHDVKLAEKVAEKVFELEPENTGYYVLMANIYAEAEKWEQVKRLRKRIGQRGLRKNPGCSWIEIKGRVNIFVAGDSSNPETENIEAFLRKVRARMIEEGYSPLTKYALIDAEEMEKEEALCGHSEKLAMALGIISSGHGKIIRVTKNLRVCGDCHEMAKFMSKLTRREIVLRDSNRFHQFKDGHCSCRGFW
The following text describes a protein:
Function:
High affinity iron permease; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MAKDVFAVPIFFICFRECVETSIIVSVLLSFIKQTLGQEQDATTRKRLIRQVWWGVAIGLFISVCIGAGMIGAFYGYGKDHFASTEDLWEGIFSLIASVIITIMGAALLRVTKLQEKWRVKLAQALEAKPLTGGTFKNNLKLWAEKYAMFLLPFITVLREGLEAVVFIGGVSLSFPATAFPLPVFTGILAGVAIGYLLYRGGNQASLQIFLIISTCILYLVAAGLFSRGVWYLENNTWNHVIGGDAAETGAGPGSYDIRQSVWHVNCCSPLVNGGGGWGIFNAILGWTNSATYGSVLSYNLYWIAVIVWFVAMRHKERHGRLPVVDPLLNRLRGRKSAEPGNGEQDVEVSTIPSDLQTESKIPKSGASLV
The following text describes a protein:
Function:
Gap class segmentation protein that controls development of head structures.
Subcellular Localization:
Nucleus.
Sequence:
MEISKVVLYNCARKLEPLNCEFCTFTSDFKLLLHRHTRSLHHNVDISRHKLSEEIKWFQCEQCAFKTKVSSNLQRHITRKHTGCHQFSCDSCSYKTQNKKNFTKHKNYNHSQDVVMYECTECPYKTKKKFSLKCHIIRRHTESEAIIEWYNCDRCTYRSKVQSDLKKHTLVVHFTDSELKWFECDLCDYKGRFKANLNKHIKRNHGGASVVFSCDLCDYKSEKKFEIKRHKYSAHLTKKRSTRGSGEIFRCELCEYKCKRKDNFRRHKLSLHSVKQEVS
The following text describes a protein:
Function:
Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MRCLSIAVAFLALFTGLYRFFDARLEQFYIFDHHHLHDLSQRAIAAHGNDTRAIVQYIVSELDEKVGSTHLNKDEEWVFNNAGGAMGAMYIIHASITEYLIIFGTAIGTEGHTGRHTADDYFNILQGTQLAYVPGSYEPEVYPAGSVHHLRRGEVKQYKMDSSCFALEYARGWIPPMLFFGYADTFSSTLDFPTLWATSRITGREMISNLLKGKM
The following text describes a protein:
Function:
RNA helicase.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MVIPDVIESERNAHLRGARDVCCHAPTGSGKTLAFVLPLLTALYNESPGQSCTRGFRRLRALVVLPGRDLAKQVHDVFVRYAKGSHLKIGLAVGGGKKKSDLVYERRSLVAYDGTTRRDNGIQVFPEFGGQSAVDILVATPGRLMDHLDSTPGFTLQHLRFLVIDEADRLVNQPYQNWVGRVLEASNSSNRFGSSVPVVRHGEKDQANTGGELVSGMFGRPVPLRKMLFSATLTQDPQKLAVLGLKNPKHFDANQVENIKAGSYSVPEGLTERMVECTAEQKPMVLLALLLDTEQLHSDSAGDGVKGVNLSIVFTSSVDSTHRLARLLQLLWEAGGYGPSSTIAEFSSSISAKQRAGILRRCRSSNVSNRVSVLVCSDGMSRGMDLPCVSAVINYDVPSYAKTYVHRCGRTARAGKEGKAISVLKGGQIAKFQRMRRLIGGGSVEKMGIKKELIKGTLSTYQACVRALKKVIEAEENEELSRSDSLVGSLYIPK
The following text describes a protein:
Function:
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway.
Subcellular Localization:
Secreted. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus. Note=The C-terminal RTEL motif may provide retention in the endoplasmic reticulum.
Sequence:
MAAPSGGFWTAVVLAAAALKLAAAVSEPTTVPFDVRPGGVVHSFSQDVGPGNKFTCTFTYASQGGTNEQWQMSLGTSEDSQHFTCTIWRPQGKSYLYFTQFKAELRGAEIEYAMAYSKAAFERESDVPLKSEEFEVTKTAVSHRPGAFKAELSKLVIVAKAARSEL
The following text describes a protein:
Function:
Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues.
Sequence:
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIKNGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNLETGNWYPELLDNVEPSFVWANDSWIFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIHLASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRMRDEQQWEELIPPRENIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRVLKQTEVPGFYAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDHLLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQGTLPATPAD
The following text describes a protein:
Function:
Uptake of allantoin into the cell.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEHQRKLFQQRGYSEDLLPKTQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMILRASYGVRGALFPGLLRGGIAAIMWFGLQCYAGSLACLILIGKIWPGFLTLGGDFTLLGLSLPGLITFLIFWLVNVGIGFGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVGIGPIFDYIPSGIQKAENGGFLFLVVINAVVAVWAAPAVSASDFTQNAHSFREQALGQTLGLVVAYILFAVAGVCIIAGASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATGNIIPAGYQIAAIAPTKLTYKNGVLIASIISLLICPWKLMENQDSIYLFLDIIGGMLGPVIGVMMAHYFVVMRGQINLDELYTAPGDYKYYDNGFNLTAFSVTLVAVILSLGGKFIHFMEPLSRVSWFVGVIVAFAAYALLKKRTTAEKTGEQKTIG
The following text describes a protein:
Function:
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MIAAKFQTFLILLAVLAGTALVARRFNIAPAILLMLSGVGLAFVPGMPPVELPPELVLLMVLPPLIYSASVAMSWREFRNNLRPIVLLAVGAVIFTAAMVAAATHYLIGLPWAIGFLLGAIVAPPDVVAPLAIARRLNIPRRLLVILEGEGLANDATALILYRFALAAIMVGHLSLPMAAGEFVLIIAGEIAFGIGVGWLSLRFRRWAKDQQVELTLSLITPYVSYWLPEHVGGSGVIATVACGLYVSWNGPLLISSATRLQGIFFWDLIIYLIEGLLFLLTGFQMRALYEKSKAFPLDDILIATAVVLTIIVTARFAWLYPATYLPRILSKSLRKRDPSPPWQWPFVLAFTGVRGAVSLAAALALPFTLPDGNAFPYRDLILFVAFGVIFVTLIGVGLTLPPVVRWLGVAEAGRNEHVAEHEAEIAARRQALDAALKSLDALTEAKEVSDEVMRLLRARHEIRVNQLPDSLDPTHHDVSAAGTALTRELIAAERKFIHDLLRDGQITDETRRRIERDLDLEEASLANREYRGVPL
The following text describes a protein:
Function:
Probable regulatory component of the nem1-spo7 complex which acts as a phosphatase and may be required for proper nuclear membrane morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Sequence:
MSSYVPNTLSVYHNLLILEASFRKTYLQLQVRRQKYMAFYVSLLVWNFYFGYRVFYRISKYSLIDLTYKLCLLCGIVTLLLFYFSGLYRTTIVYPSRYVQQVNKAMRFFNIRLVITPVPWFQVRKPLDCGVHLILSSKRFDILVIEGWEAFRSSYFASIHRKNNSIQSNESSESPSSKQN
The following text describes a protein:
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Sequence:
METEQVDNIQANVLAIPTFEAMGLKEDLLKGMYSFGYKQPTAIQKRFIMPFLKGRDVIAQASSGTGKTSAFCVCLLQACDPHTRETQALILSPTRELAVQTQDLCNNIGHHMGLTAYACIGGKSTEEDIRRLESGVHIVSGTPGRVFDMIRRKSLRVNGLKTLVLDEADEMLGKGFKAQIHDIYRMVPPLQIILVSATLPADVLEMTEKFMTEPTSILVKRDEITVDSVKQYFVSVDEEKNKFDVLMELYDSLTIAHAVVFCNTRKKVEQLAKKMTREKFAVSAMHGDMPQAERDEIMRQFRNGHSRVLITTDLWARGIDVERVSLVLSYDLPLAREQYIHRIGRTGRMGRTGLAITFVRHDELRLLRDIEQFYATQIEELPANIGEQM
The following text describes a protein:
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Sequence:
MVNDKEIEALGSILVNVEEPLRARFRALFTLRNLGGSAAIDWISKAFADDSALLKHELAYCLGQMQDERAIPTLVSVLEDTRQEPMVRHEAGEALGAIGNPKVLDILKRYSEDPVIEVAETCQLALRRIEWLLSGQEQWKDDSPYVSVDPAPPAPERSVPELRTRLLDESLPLFDRYRAMFALRNLGTEEAVLALADGLQCGSALFRHEVGYVLGQVQHEACVPQLAAALARADESAMVRHECAEALGAIGKEPCLRALREHLGDRERVVHESCEVALDMYEYENSGQFQYADGLLRLQGAQ
The following text describes a protein:
Function:
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.
Subcellular Localization:
Nucleus. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.
Domain:
The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.
Sequence:
MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSEDLEPLAGGSPEATSPDVTETKNSPLMEDFFEEGFSQEIIEMLSKDGFWNSNFGEACIEDTWLDSLLGDPESLLRSDIATNGESPTECKSHELKRGLSPVSTVSTGEDSMVHNVSEKTLTPAKSKEYRGEFFSYSDHSQQDSVQEGEKPYQCSECGKSFSGSYRLTQHWITHTREKPTVHQECEQGFDRNASLSVYPKTHTGYKFYVCNEYGTTFSQSTYLWHQKTHTGEKPCKSQDSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFHLTRHQKIHTRKRYECSKCQATFNLRKHLIQHQKTHAAKTTSECQECGKIFRHSSLLIEHQALHAGEEPYKCNERGKSFRHNSTLKIHQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQECVRSFSRPSHLMRHQAIHTAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLKCHESVHAREKQGFFVSGKILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRVFTQRNYLVQHERTHARKKPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQETLYQCQRCQKAFRCHSSLSRHQRVHNKQQYCL
The following text describes a protein:
Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.
Subcellular Localization:
Cytoplasm. Nucleus.
Domain:
The U-box domain is required for the ubiquitin protein ligase activity.
Sequence:
KEESSLDLIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASVPGPSQSLGLNVHNTTPATSPIGAAGEPQSPTWRLARLSLHWIDMFLFCPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIATAARSPDRNLMLNTGSSSGTSPMFCSLGSFSASSLSSLGASGGASTWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQCSLLSGYIMSWALGELCETKFGKTHPMCNLVASLPLWLPKSLSPGSGRELQRLSYLGAFFSFSVFAEDDAKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAIVNANMKKAQMQADDRLVSTDGFMLNLLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRINATMEDVNEWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLMLRVLDPAYPDITLPLNSEVPKVFAALPEFYVEDVAEFLFFIVQYSPQVLYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPSVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNQEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHLLTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQMLTESMLEPVPELKEQIQAWMREKQSSDH
The following text describes a protein:
Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
Miscellaneous:
MISCELLANEOUS: Present with 7110 molecules/cell in log phase SD medium.
Sequence:
MSSDAIRNTEQINAAIKIIENKTERPQSSTTPIDSKASTVAAANSTATETSRDLTQYTLDDGRVVSTNRRIMNKVPAITSHVPTDEELFQPNGIPRHEFLRDHFKREGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDEVLDKDLTEEDIVNSKTMVPHHGKMAPSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKTLGFPSLLTLFSAPNYLDTYNNKAAILKYENNVMNIRQFNMTPHPYWLPDFMDVFTWSLPFVGEKVTEMLVAILNICTEDELENDTPVIEELVGTDKKLPQAGKSEATPQPATSASPKHASILDDEHRRKALRNKILAVAKVSRMYSVLREETNKVQFLKDHNSGVLPRGALSNGVKGLDEALSTFERARKHDLINEKLPPSLDELKNENKKYYEKVWQKVHEHDAKNDSK
The following text describes a protein:
Function:
Regulates prospindle assembly during late prophase and at the onset of mitosis, before nuclear envelope breakdown (NEB). Is exported from the nucleus shortly before NEB and organized into two polar crescents. After NEB, is progressively associated with the forming spindle. Probably mediates AUR1 activation and localization to spindle microtubules. Has a microtubule binding capability and is able to trigger microtubule assembly induced by RanGTP in a heterologous system. Not involved in phragmoplast assembly, nuclear envelope reformation, and cortical microtubule assembly at the onset of G1. Involved in the formation of specific nuclear and perinuclear microtubular arrays in the nuclei of acentrosomal plant cells. Fungi and plants have acentrosomal microtubule arrays because they lack centrosomes. They use other microtubule organizing center (MTOC) structures to organize their microtubules. May function through interaction with importin.
Miscellaneous:
MISCELLANEOUS: TPX2 over-expressing cells display formation of nuclear and perinuclear microtubular arrays which are not specific for the transition to mitosis and occur independently of AUR1 kinase.
Subcellular Localization:
Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Located in the nucleoplasm during interphase until late G2, in the perinuclear region during early prophase, and at the spindle during mitosis. Localized on a specific subset of phragmoplast microtubules in early telophase.
Domain:
The N-terminal part of the protein is required for the interaction with AUR1. Two regions (220-463 and 684-758) seem involved in the targeting to the microtubule cytoskeleton.
Sequence:
MEATAEESVSTLVTTMVDETYEFLAPRWFDFVNGETEDESRRAELWFQSALSCAPSPSVPRIKARRSFKVEAMCNFNEAEEETLKDKEPLEPVVPIVSLQSQPSQAKKAEVAPSKASTVKPSRISSKDAEVNNKTVDASDPTTEPIEDKENIAPACTPKPPMQFSLGAKSVDLKKQQTARKIASLLKNPSTLRPKNQSQAKGSHQKSVKGETNLNNIASTTNLIQENQAIKRQKLDDGKSRQILNPKPATLLHKTRNGLVNTGFNLCPSVTKHTPKENRKVYVREQIAPFVSTAELMKKFQTSTRDLFVQNRPKLTLTRPKEPEFVTSQRARPLRVKSSAELEEEMLAKIPKFKARPVNKKILAAPALPAPQRSTPHLPEFQEFHLQTMARANQHAETSSIASTEVSKQHNDQKHHLTEPKSPVLQTMLRARPTIAKTTAELEQEELEKAPKFKAKPLNKKIFESKGEMGIFCNTKKHITIPQEFHFATDERISRPESVLDIFDKLSLNSESCHEKPLPRNTAPNPFNLKTEERGAEKEKKFYMELMYKKLGDVKARVPKANPYPYTTDYPVVPPKPEPKQCTQPEPFQLESLVRHEEEMRREREERRRMETEEAQKRLFKAQPVIKEDPIPVPEKVRMPLTEIQEFNLHVEHRAVERADFDHKIKEKENQYKRYREESEAAKMVEEERALKQMRKTMVPHARPVPNFNKPFLPQKSNKGTTKAKSPNLRVIKRTERRTMMARPTISAATSASAVHCLMYPGSSFNKLKKKTVLTNIVHCLMYPDSSLLN
The following text describes a protein:
Function:
This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MKIRSQVGMVLNLDKCIGCHTCSVTCKNVWTGREGMEYAWFNNVETKPGIGYPKNWEDQEEWQGGWVRDVNGKIRPRLGNKMGVITKIFANPVVPQIDDYYEPFTFDYEHLHSAPEGKHIPTARPRSLIDGKRMDKVIWGPNWEELLGGEFEKRARDRNFEAMQKEMYGQFENTFMMYLPRLCEHCLNPSCVATCPSGAIYKREEDGIVLIDQDKCRGWRLCISGCPYKKIYFNWKSGKSEKCIFCYPRIESGQPTVCSETCVGRIRYLGVLLYDADRIEEAASTEREVDLYERQCEVFLDPHDPSVIEEALKQGIPQNVIDAAQRSPVYKMAMDWKLALPLHPEYRTLPMVWYVPPLSPIQSYADAGGLPKSEGVLPAIESLRIPVQYLANMLSAGDTGPVLRALKRMMAMRHYMRSQTVEGVTDTRAIDEVGLSVAQVEEMYRYLAIANYEDRFVIPTSHREMAGDAFAERNGCGFTFGDGCHGSDSKFNLFNSSRIDAINITEVRDKAEGE
The following text describes a protein:
Function:
Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway (By similarity). Essential role in regulating development, stress response, and longevity (By similarity). Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function (By similarity). Plays a role in the intracellular trafficking of proteins such as mig-14 to the cell membrane, and this may be through positively regulating ceramide synthesis (By similarity). Acts downstream of rict-1 to regulate fat storage, size, and development (By similarity). Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development (By similarity). Does not appear to play a role in immune function (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus. Apical cell membrane. Note=Localized both in the cytoplasm and in the nucleus in neurons, exclusively cytoplasmic in the intestine. Localizes to the apical cell membrane and diffusely throughout the cytoplasm in intestinal cells (By similarity).
Sequence:
MGSLYYSGSRMVRKDEVSCKLVMGDDKKTVVYAVRIGDGPIMQKVYEEYEKFFLTDVKDMVPEKFTIFPKKKLLQSKKTFFEKRRLWIQDVCQHLVDNQTKSEDVCRFFHIEAPDDDDNTVDLGPSERKTATANDFDFLTTIGKGSFGRVYQVRHKETKKIYAMKVLSKEHIRKKNEVKHVMAERNVLINNFKHPFLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFTESRSRFYAAEIACALGYLHEKNIIYRDLKPENLLLDDKGYLVLTDFGLCKEDMQGSKTTSTFCGTPEYLAPEIILKKPYDKTVDWWCLGSVLYEMIFGLPPFYSKDHNEMYDKIINQPLRLKHTISVPCTELITGLLQKDRSKRLGHKNDFRDIQDHPFFLPVDWDKLLNRELKAPFIPKVKNAMDISNISKEFVEIQIDPASLAPQQLAVTHRDHDFENFTFVDTNRVLV
The following text describes a protein:
Function:
Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.
Subcellular Localization:
Postsynaptic density.
Sequence:
MNIRGAPDLGQPSDDPNSGGERERIRQRMKMVIGQLEGILRELKEVAKELREVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGAGGPFDLGHLDFMTADILSDSWEFCSFLDVSTPSDSVDGPEAPRPGTGPDYQLMNGGLPIPNGPRVETPDSSSEEAFSAGPAKGQVPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEEVEEEEAGLAPELPRVEPHTGPLKPSPAPYKTKRSPLTTRRLGPTLAPEQTRRVTRNSSTQTVSDKSTQTVLPYTATKQKAKGKN