lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MWIILSAVFVQIVFLLSVFDIHFHSPIVKGMTPYANPIPAPAKRLVLFSADGLRFDTFLSYGNDREPNAKFLRSIASSRGKWGLSNTRVPTESRPGHVAMIAGLYEDPSAVFRGWKENPVEFDSVFNQSSYTFGWGSPDILSMFSKGTKGNVMSYTYSSESEQFTGHDAYKLDEWVFEHFERFIKMAPHNATLSSMLQERKLIFFIHLLGLDTNGHTNKPHSTFYTDNLRYVDQGIAKIEGLINDYFKDNQTAFIFTADHGMTDWGSHGAGHPSETQTPIVAWGAGINTKNIDAAHWENNRNDMEQADVAPLMAALLGINFPVNSVGKLPLAYLADEMLWKSHCALANVQQLSRSFQALTQRQQDRSLSLRFRPFWPLESNQVSAHNLQQIEASIRSGYYNESIQQSLNLMDLCLQGMDYFYRYDEFQLKMFITLAYIGWAGILAVFIIQERVTTSKKKTGHQFRLIDQIVFGLSVVIFIVLTVEGVPFLYYAYHLLPLMLWWYCLRQSKQMLRQTIRLIRIRHFVWATFLLGGLEFIVAGFFYRWFLSVGLVFMSLWPHWDQHSSSRWRHHETFKSLWMFTFLILAMFPVFPPVGKHSVPILVDIGGMILTVMAFWSSLVMHHDRDRTVLVCYTIAIPITLYVRHSVSDSLVQGQGLPVLEQALSWILLCLPLTLPLIGPSLVWPRLIGIVITLTPSFLLLSLSYEGIFFAVLVVALAIWIRLEAAIPATDSFWTQLRRSYFFLFLTFLSFFGLGNLASLNSFDPSSVRCFVTTFSPFTMAGLLLWKITVPFIAVSSALWAITVQHQLSMKNVYLMILLLSAAMAVQFFHWVTSRGSWLDIGTSLSHYVIVQFTVVFVMLLRSVVQFLTHGPIYFHATRPTASKYDKD
The following text describes a protein:
Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MKALSLRRGLVARASAVAYTSQCWCSTDAKSEKRAEEKEAPSTGTEEVVSAAAVKQLEKELDASKAKIEELKKEILYRAADAENARRIGREDVEKAKFYGISSFGKDMLEVADTLEKGVEAFSAFSEAELNENKILCSIFTGVKLSHKVLLKNLSKHGIEKMGVTVGTKFDPNLHDALVSTSATETAPADTISNVLKDGYTLKSRVLRAAQVSVSQHP
The following text describes a protein:
Function:
Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Can catalyze the reverse reaction but at a much lower rate in vitro. HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate. Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site). Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro. AREs direct rapid RNA degradation and mRNA deadenylation. Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite.
Subcellular Localization:
Mitochondrion.
Sequence:
MAAAVAAAPGALGSLHAGGARLVAACSAWLCPGLRLPGSLAGRRAGPAIWAQGWVPAAGGPAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MADHHLQNTQPMTHQMVKAATAATAGGSLLILSGLILAGTVIALTIATPLFVIFSPVLVPALIATALLATGFVASGGFGVAAVTVLSWIYRYVTGRHPPAADQLDSAGMKLASKAREMKDRAAQLTGAAAS
The following text describes a protein:
Function:
Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis-specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere.
Subcellular Localization:
Cytoplasm. Nucleus. Chromosome. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere, M line. Note=Chromatin-associated during mitosis. In indirect flight muscle, colocalizes with sls isoform A (kettin) to the sarcomere Z lines and appears to be weakly distributed across the sarcomere. More rarely, localizes to M lines.
Sequence:
MPRVAKPKAAAPAKKVVSAKKAKSKLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGDFKPDPKKMHNGTIEYTSRDAHLGVPTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPNNGDLDFKMKPQTSSNNNLSPPGTSKAATARKAKKIDSPVLNSSLDEKISASEDDEEEEEKSHRKKTAKKVTPSARNAKVSPLKRVADSSPPSQKRVKTEPKSTPRERATPKASPKPRSTPKASPKPQTPTAARLRTPNAKINFSPSISLRGRPGGKTVINDDLTPQPRSKKTYEFNFELDVSMDANVIVNVKRKKKADQDKATAVDSRTPSSRSALASSSKEEASPVTRVNLRKVNGHGDSSTPGRSPRTPAVTVRKYQG
The following text describes a protein:
Function:
Plays essential roles both in the penetration of the viral genome into the bacterial host via pilus retraction and in the extrusion process. During the initial step of infection, G3P mediates adsorption of the phage to its primary receptor, the tip of host F-pilus. Attachment of the phage causes pilus retraction bringing the viral particle into close proximity of the host cell inner membrane. Binding to the host pilus initiates a change in the G3P conformation, allowing subsequent interaction with the host entry receptors TolA, TolQ and TolR and penetration of the viral DNA into the host cytoplasm. In the extrusion process, G3P mediates the release of the membrane-anchored virion from the cell via its C-terminal domain.
Subcellular Localization:
Virion. Host membrane; Single-pass type I membrane protein. Note=Prior to assembly, G3P is found associated with the bacterial host inner membrane. There are about 5 copies of this protein per mature phage that are located on the head side of the filamentous virion.
Domain:
Consists of 3 domains (N1/D1, N2/D2, and CT) separated by glycine-rich repeats and a C-terminal transmembrane segment. The N2 domain interacts with the F pilus, whereas the N1 domain forms a complex with the C-terminal domain of TolA at later stages of the infection process. The C-terminal domain is required for release of viral particles from the host bacterial membrane and proper integration of G3P and G6P proteins in the virion.
Sequence:
MKKLLFAIPLVVPFYSHSAETVESCLAKPHTENSFTNVWKDDKTLDRYANYEGCLWNATGVVVCTGDETQCYGTWVPIGLAIPENEGGGSEGGGSEGGGSEGGGTKPPEYGDTPIPGYTYINPLDGTYPPGTEQNPANPNPSLEESQPLNTFMFQNNRFRNRQGALTVYTGTVTQGTDPVKTYYQYTPVSSKAMYDAYWNGKFRDCAFHSGFNEDPFVCEYQGQSSDLPQPPVNAGGGSGGGSGGGSEGGGSEGGGSEGGGSEGGGSGGGSGSGDFDYEKMANANKGAMTENADENALQSDAKGKLDSVATDYGAAIDGFIGDVSGLANGNGATGDFAGSNSQMAQVGDGDNSPLMNNFRQYLPSLPQSVECRPYVFGAGKPYEFSIDCDKINLFRGVFAFLLYVATFMYVFSTFANILRNKES
The following text describes a protein:
Function:
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation.
Domain:
The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.
Sequence:
MALRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTFQPPGAGFPYGGGALQPSPQQLYGGYQASQGSDDDWDDEWDDSSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGGSVPPQHHPSGPKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGEEASRDVDAWVFSLECKLDCSTGSFLLEYLALGNEYSFSKVQRVPLMTVLSF
The following text describes a protein:
Function:
Plays a role in nonsense-mediated mRNA decay.
Subcellular Localization:
Nucleus.
Sequence:
MNLCAQILRQAEALKADMTDSKLGAAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQSQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVRSSQLGIISNKQGSGGAIVTPQPSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDELKSKWSVSDFIKAFIKFHGHVYLTRSVEQLDALRQKLEEQFQRLILQKAFSSQQLVHISVINLFELHHLRDLTADERSFSCEQQTCWFQLLGLFMSFLGLMCSRVLLNKNQDEEIMGECPLPAIKLSLDWLRLRPSVFQESAVEQRQHIWAWLVSILNSFQPREEDLSCSSAAPLPEEFELQGFLALRPALRCLDFSKGHQGILVDRDGLPVHARHQRLASLGKWVCDTQPGLMQCHVSEDGLLVFLTDIPEQAIEEPQEKEVPVLQESSNGEQNDGGNSGLKSVLSAGKTQSSWSDGGERPVVTFKENIKPRDQSREPARTPVLKDASKERRDFLKGNAGKVEPKRDGKRKSEVKKSPLDKPADAGKQVKAQMELRKTPVSEVKKTPGTQTQTTCSSQFIPIHHPGAFPPLPSRPGFPPSAYVIPPPVAFPGLQVSPGFTFSPGVSVPGNFLQQAVHSQAGAQVQGGKQSHIPYSQQRPSGPGPMTPGPPTSQQALQLQVQAMSQQQSPTKPVHQVGLGKSPPHHPGLQQFMQVQDQPTKMWSQAALQKMPPMQVSPKQQPPFFMPHQESLKLFEPPPQLSSVDNKFSDVKMPDFPWEPWMSDMRMKRPPPGVVCADQEASVGPRGPPFEDNKSSPLLPPDLLKTLADLEAEEELLFAKPPDFLQALAGPLSSAPGPNMFSNQSRMESGPEPSSQSSSLLPIPGFPMQEFNQKSIFSQFYGKNLPPSSKPEVQQEPSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHSHGGVPFSNFGPIGTPDSRDRRGADRWKAEKSGGVSGFGLDYLPTAPPSTLPDTTWHQGGSTGSWTNQETPMEESSSTVLLDSLKSIWSSSMMQPGPSALEQLLLQQKQKQQRGHGAMNPPH
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Thereby required for nuclear import. Required for the proper organization of chromosomes on the mitotic spindle during anaphase.
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MFSHLNQNTSGRHNSMDLNNSSISNFGTPVEQSTPALLFGKRKATVPSSYTASPLNTASAPCSDIFAVSAPAVPQHLKDTPGSKSVHWSPSLVQSGEKSAAQTQNTPANLSFGGNSSFSAPTKPAPQSIQTSSFGGQAMHAPPLRSLRDKVEPAKKISRRNTFTARSTPLSTPITQRVTSRLAEAEEQPMEEEADAADTWVTVFGFQPSQVSILLNLFSRHGEVVSHQTPSKGNFIHMRYSCVTHAQQAISRNGTLLDQDTFIGVVQCTNKDVINGSASGIVARSSNIAAAANRSASMYNSFVENDMADQSVNHNENSVLNSSNVFDANNSLNSSRISVRSGVGMRPLAADQRTNILQGTPSVRKAPDGLLNKFWNTIGLN
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MEDEDASQPPQHLARDRLKRLKQAWLNEVNAPELLPFETDAVRWLHDAVTAQNEQAEAGAYQDLNTKFAFAIYRMEMDRIRYLLSSYLRARLRKIEQHIFHLVHNEDQLRRLSPQERAFVSNYRRILQNHLDQAFLQQIPGAAKPSCNMEFLLTMWRHAHDDFHQPLTLENFRSLNDPQIIEQPNLDRHVFCQFDAPLDVLPLSEDPADRDLVLRDVRRGDVYLLRYRVVRELLLDQTAHLV
The following text describes a protein:
Function:
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.
Sequence:
MSVKSVLSDMEWDSGLQIPVANQVNKLLEAHVAKGQKEKAKLQGEVSQNEDRVHAMSEHMKNVQQELNQTQNLCRARDNEIETENHMKLVAQREEGRLKQEIVRQENDLGDIKERKNIHQNTIFKNTQKLEELKSQLNWDQQALEAWLEESARKDEDFMTITKYRQIDDAKLKELRLQMERMTEICQKKKKDLNSEMTETLTAQLEMDKTAEEFRKSHNDRQQLIEQWEQTIEQMQRRDREMDRLATKLAEAKSDLMDHEEMVKEKQQFLESEMENNQEQNKKIQATDRLAARLRLDYQDNENQRIQFADELETLKFTVERTATDLEAMRRQVNELKKDVEVKKERVENAKRHRGELMSKLKSATDQSLSAEEMAAIMDGMLQDEETTLHFLEQELKRLRDLQYKRSQELYEAKTAEKNTNAEIQGARAASRNLSSRINKMDHDSLKQQEIIYNQDFTVQQLERKIARLEGERSTEEMDMLNARIKELTNFLEERNNTHGLLSNQLKRLQDDIRRVKRDLDKSGAEKADLTSKIEELNLHNDSSNRELKHIVRDKQDQMVDENILKLELKRLRDILNSRADEVMTLEKRRLQLETAMNERRKEITIHKEMLRAQLKANEEERSTVSSELHDRIGRIDKLRKRYEILMVTMAPPEGEEDRSQAFYVIRAAQEKEALQRKGDELDARIRKAEKEIKALENTLRLMNGRNEQYRKSFNRVTETSEEFEEKQRLEEQLRAAMDKYKYKRRQIRELQDDLQTMSSTMENLGRDESAYSEMIQEKENKKQQLSKELDDQKVKIDRVMKQIARYAKELRASRRVKGETHEENDFELRELREFNKNVMKMMGEVIHSYPDISPTAQMLFSQAGLAVPPPPSATQRSSRPGSAYSSRSLTSPKTPSSVRSGASSRASSLGMKTVDVGGFGLSSSPAGTPKSGRSPAGSRAGSRVSSQGSLRSGRR
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MTDRRNSTAVVAKRRTDTPIETDEIRALCEAAGVEVVAERTQARPRDPTYDLGDGAVADIAGLVERRSADLVVVDDHLDPGRAHNLQEAVGAEVVDRARLVLDIFGERAETKRARLEVRLAELRYELPRAQARVERGETQGRQGFRSGGERPAAQLKADYRQRITDRRAELDRLDDADDGLREARRESGFDLVALAGYTNAGKSTLLRRLADDLAVDENDGHGDRTDTAASRDRLFETLNTTTRRATVGERRVLLTDTVGFVDDLPRWLLSSFRTTLAAAREADAVLLVVDATDDREGIRAKVEASRDELADAEGTLVPVLNKRDAATDLDAKRRLLAEHAGHAPVVTSATGAEGLDALRERLTDALPDRRRVSLSVPNTDAGNAFVSWCHDRGTVHEPDYGERIAFGFEARPEVTAKATGRAEQLNED
The following text describes a protein:
Function:
Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.
Subcellular Localization:
Mitochondrion.
Sequence:
MASKSLHSKLRSLLPRRCPHIRTATTAAATRGTTQANSHYPPSSTQIKRPSTSSYVPSTRSKMSFTRPTPSQIDPVLNTNETDRTELTRTAKRTRKREKPLSEEEQEKQRLEREEELTANLEKSFKPPKILFENEKVVVIDKPAGCALQAELGSEAYIRWKLIMDYLEKRRGKLFIVHRLDKSTTGPLILAKSSTASRTLSTQFKNSTVKKTYYAAIQFLGDRIGPIQDAKSSGQIECRMRDSKDRMVIAESNRTGTDCKQTKTNWELVTATSNHAIVRLTPQTGRKHQLRLHCSRFLAGPIVGDFKYDFRYLSYQSQKAIHNFLNREAPGRLLLHCSEIEFKLYKKEQPREYTVRVSSPLHDDFRIVCDQLDLSTNAIH
The following text describes a protein:
Function:
Required for mesendoderm differentiation. Interacts with glucose transporters and promotes glucose uptake. Probably augments the glucose uptake capacity of glucose transporter proteins to meet the energy needs of mesendoderm differentiation.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MEWKLNLLLYLALFFFLLFLLFLLLFVVIKQLKNSVANTAGTLQPGRLSLHREPWGFNNEQAV
The following text describes a protein:
Function:
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEANRSRLLAAARPYIQIYSIFGLTPPIQFFTRTLHKRRRGIVILGYACYLISISLMVIYECYANIVALQKDIHKFHAEDSSKVMGNTQKVLVVAMFVWNQLNILLNFRRLARIYDDIADLEIDLNNASSGFVGQRHWWRFRFRLALSVGLWIVLLVGLTPRFTLVALGPYLHWTNKVLTEIILIMLQLKCTEYCVFVLLIYELILRGRHILQQISVELEGNQSRDSVQELCVALKRNQLLAGRIWGLVNEVSLYFTLSLTLLFLYNELTILQIVNWALIKSVNPNECCQYRRVGTCLLLSINIFLSCLYSEFCIQTYNSISRVLHQMYCLSAAEDYLILKMGLREYSLQMEHLKLIFTCGGLFDINLKFFGGMVVTLFGYIIILVQFKIQFFAQSNFMQNINSTELKAYTA
The following text describes a protein:
Function:
MFS-type transporter; part of the gene cluster that mediates the biosynthesis of 5-hydroxy-2-hydroxymethyl-1,4-pyrone, also know as kojic acid, a by-product in the fermentation process of malting rice that acts as a chelation agent. Involved in the secretion of kojic acid. Improves the antioxidant capacity via the accumulation of kojic acid that is also a strong oxidant.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MQSFRQYRRMRRDLQESIKLHGPYAAAGDRHVQPTDDILEDADDARLEKGIHSMNGHGQSPYSTPGIVLHDGQRVTVPGVNLRRASEICERVNTKTLFIVGFDGPDDQLNPKNWSIGRKWATLGIVGTTGMLVGWASSIDSTVIKQGQEAFGVSEVAESLATALFLFAFGFGSLVAAPFSETVGRNPVYIATLSILMIFTMASGLAPNFGAQLAFRFLAGLFGCTPMTTFGGSMADIFDPMDRTYAFPVCCTLSFLGPFLAPMVGAFIGQSTHISWRWTEWCTLIMAALVTGAIFLFVPETYGPVLLQWKAKQLREITGDPRFMAEIELRQTSLVTRLMHSCSRPFHLFFREIMVALFTMYLVVVYIVLFGFLTGYEFIFGRTYGFTQGSVGLTFIGMNIGFLIAFAMVPHIYFSYKKRLQNAIENGHNGLPPEERLWFAMYGAPWLPISLFWMGWTSYPSISYWSPLVASVAFGFSVQGIFISTYQYLIDTYELFAASALVSATFFRYIAAGAMVIVSIPMYGNLGVHWSLTLLGCISVLMTPVPYIFYKYGHVIRQRNKKTP
The following text describes a protein:
Function:
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRRSPRSLRLRLSADNLVAASGGCWSVLGERRAGSLLSASYGTFAMPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYRRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKGLHEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNFPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSGVDVA
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
KKKLLILDVNGLLVDTYFMKEDRPPRLHDAVVGRFLGESSNPWRPHCEEFLQFCLRHFHVAVWSSAKEHNVMGMVNLILGESKKLLAFIWSQKWCTDTGVKCLDNKFKPLFLKELKKVWESSKPDVPWDKGEYGPWNTLLIDDSPHKVLRNPDHTAVLALPYSAMETTTSADDFLPALQGYLTKLIDVPDVRDFVRSNPIGQPLITEDSRDWDFYSKL
The following text describes a protein:
Function:
Transcriptional regulator that represses the expression of ydaS and ydaT under normal physiological conditions. It binds to its own upstream sequence and represses the adjacent and divergently coded ydaS-ydaT operon. RacR-mediated down-regulation of ydaS and ydaT may be critical for cell survival. RacR ensures that the prophage DNA is maintained in the genome. When the expression of the racR gene is reduced, the prophage Rac is excised from the genome, possibly to counteract the lethal toxicity of YdaT.
Miscellaneous:
MISCELLANEOUS: Encoded in the Rac prophage region.
Domain:
Contains a DNA-binding N-terminal domain (NTD) and a C-terminal domain that facilitates oligomerization.
Sequence:
MLSGKDLGRAIEQAINKKIASGSVKSKAEVARHFKVQPPSIYDWIKKGSISKDKLPELWRFFSDVVGPEHWGLNEYPIPTPTNSDTKSELLDINNLYQAASDEIRAIVAFLLSGNATEPDWVDHDVRAYIAAMEMKVGKYLKALESERKSQNITKTGT
The following text describes a protein:
Function:
Adrenodoxin reductase transfers electrons from NADPH to adrenodoxin, which is involved in heme A biosynthesis and in iron-sulfur cluster assembly. Involved in the electron transfer to heme A synthase COX15, a heme protein that catalyzes the conversion of heme O to heme A. Required for the de novo synthesis of Fe-S clusters on iron sulfur cluster assembly protein ISU1. Involved in electron delivery for Fe-S cluster synthesis. Essential for coenzyme Q biosynthesis. May be involved in the electron transfer required for the hydroxylation reaction performed by COQ6. May play a role in cellular and mitochondrial iron homeostasis.
Miscellaneous:
MISCELLANEOUS: Present with 1600 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein.
Sequence:
MSFVQIRHISSQINRKTVSIVGSGPSGFYTAYHLLKKSPIPLNVTIWEKLPVPFGLSRYGVAPDHPEVKNCEETFTTCAEEFSSPTNQKHKFSFVGGITIGKEILLKELLDNQDAVILSYGCTGDRKLNIPGELGTKGVFSSREFVNWYNGHPDFAKDKRFTDFDWSKVSKVGIIGNGNVALDITRVLISNQIDEIWENTDISSLALNLLRRAPVKDVKLIARRDFVHSKFTNKELRELWELEKYGIRGRIDPKFFQKEMFDPSKYDRAFNRRVEMCSEYLKPFNERSKKNYKKAPPPSSGYDKFWELDYLKTPLKINRDDFGAINSLSLCNNRLNEDNSLQPLKDVNNIMTYKVDLLITSLGYAGVPMPEFSKLSIGFDKDHIANKQGRVLTSSGEIFPHLYASGWIRKGSQGVIASTMQDAFEVGDRVIQDLVVSGALSLENSIDLSNIKHTTWKDWERINKKELLRGKKEHKTRSKFLTFEELWNGVEGI
The following text describes a protein:
Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body.
Sequence:
MTRRKSLRNNPLGHEPPAIFHLSLRLRGGAQLGKAVKGRSKDGKGKKDGSGRETSEEERRLQESIRRMEMNDYMKRLTVSKKALLLEFMAKEERISRMNKLKIQNHWRKIMRLVKVEALRKEVEVRSQNHERDVDRKDALIQMLDRDLEEAEEQFQMALRAHLLNVDELIDLQDERLLVLEKEFEADLRELEQEFHTEKNKLVTQHSMERSELQRIMQAVDQQEKEREADAKQEHEQLREEIRNKNLEDINVLRITLDSSIEELEQHFETAHLNYLQNTDQRTQDFKYLTAKDQDLSRDIELKIRKIERLQQSLALWRTKIAQNVRECSERNKALEEEKAAISHHFQTLKAKMNRMRDDQRRRLAQLSQGARDATRKLDTHLQLSERILQLGELVRKLETERERVLPFYHSTLADEREANELTESVRLAMRTEQGREEEEALQMLDFQPQGLHDGVPVSEWEYLDLFWKRHNKVLLDEIALRREKERVANENRELQTILQQYLAGISVSPTVLDGANPLLVVNGRLRLHQPSLGEDGKPRRKPVIDANHMVETNRVSR
The following text describes a protein:
Function:
Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAALSSAWGVVALESRGGLGHRGQDGNVSSCSGRSDSGVECAMRSTRASQRKIASMRIKLQSALSRCEALLSLSVYPVRSSVHSRALKVDDVLVTESWLSSEEEVSCHDAEEAMALALEAVKAARAASSYADAMKVENDEFPSEFDLLRLERARLNDMEQTFREDYHAEAAMLEAEQSYVQKLELLLEDVSTLVGEAEGTSSVVANPGSENAETLDVLPPTKVSNVAVKSKRKGERRKKRERALEKAEKLATALASAPPAPRPKKPQISQEPTDPVRAYLRDIGKTKLLTASEEVALSRKIQDLLVLEKVKSDLQREIGREPSIGEWSRAVGMEQNAFELRVKEGRYSKDKMVNSNLRLVVSIVKNYQGRGMTLPDLIQEGSMGLIRGAEKFDPDKGFKFSTYAHWWIRQAVTRAIADQSRIIRLPIHLYEVISRINKAKKMLIQEHGRQPRDEEVAELVGMSVEKLKFIVKSAKTPSSMDRLIGKEKDQSIGEMIADKDVESPEDDLIRQVLKQDVDGVLCTLNPREREVLRLRFGLDDGQSRTLEEIGTLFKVTRERIRQIEAKAMRKLRQPSRNGVLREYLDVKDG
The following text describes a protein:
Function:
Required for translation, stability and/or localization of lin-15a.
Subcellular Localization:
Nucleus.
Sequence:
MDHHAMYRTAEFNKTTVRLLAEFIEKTGQNATIVNMDSFLEFFAYLNPTAPIPTVPEIEKQLLLKSPIRCIVCGMETESDSAVTLSIDNASIILTATVIGYCRDPSDAVNQIRKESLRACTKHFNSIFHVIFEGLQIENTYCAHHAKYSLANRWCKVYTMIRSSLGEQFTKFDVRNFKSILQSFLDTFGEIDDDKKDKESSHFDECFEEMDSENVEIKMESPQEEAAEKSKFSENLVEVKLEPIETHELDKTISDFSSSDIIDSSQKLQQNGFPEKVEQMDKYSNKLKDEASDKKYEKPGKKDYVEEEGYWAPITDSEDDEA