lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MPRRKVFAWSISLQNAIIPLYIISKVGCLNAFTYLPLFHFLDTYAGCKSDKCVKIGTADIPVKRFKGKDGKPLAFSFIGVLHALGCSLAYASYHILSSLSQSGKLTDSNLVRVAIDLKNQYIGCILVLGIVMVSLVRQPAFSRLIQVLLSVDRAIPEMVRTAGLSAITKVKVNNIVWLRNVLLMLILGVGVKAVLEVTNCLMYIRDSGSPFSSNCLLLCIIPQTLCVISELQFVAFALLISERLKLLNRWLLQLLPHLGRGSEAAYESVRHLVRIHGQLLKAIGLLNCCFGVQNTILLLYQFVTLVELGYNTCMMSVRYAEAKVQQGDSTEDFLETVYWVVWFVVEIFVLCYFSHDTVEEARRTVHLLRMPNVYGPCQRINFRTISQEQLVFRNVKTSISCCGLFTIDLTLFHAIIGATTTYLIILIQFDQSFNGD
The following text describes a protein:
Function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular Localization:
Cytoplasm.
Sequence:
MTTVRTRIAPSPTGDPHVGTAYIALFNLCFARQHGGQFILRIEDTDQLRSTRESEQQIYDALRWLGIEWDEGPDVGGPHGPYRQSERGHIYKKYSDELVEKGHAFTCFCTPERLDAVRAEQMARKETPRYDGHCMHLPKDEVQRRLAAGESHVTRMKVPTEGVCVVPDMLRGDVEIPWDRMDMQVLMKADGLPTYFLANVVDDHLMGITHVLRGEEWLPSAPKLIKLYEYFGWEQPQLCYMPLLRNPDKSKLSKRKNPTSITFYERMGYLPQALLNYLGRMGWSMPDEREKFTLAEMIEHFDLSRVSLGGPIFDLEKLSWLNGQWIREQSVEEFAREVQKWALNPEYLMKIAPHVQGRVENFSQIAPLAGFFFSGGVPLDASLFEHKKLDPTQVRQVLQLVLWKLESLRQWEKERITGCIQAVAEHLQLKLRDVMPLMFPAITGHASSVSVLDAMEILGADLSRYRLRQALELLGGASKKETKEWEKIRDAIPG
The following text describes a protein:
Function:
Plays a role in detection and sensitivity to pheromones and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Necessary to mediate behavioral responses to cVA by regulating both male and female mating behavior. Activation of Or67d neurons by cVA inhibits courtship of other males, whereas in females their activation promotes receptivity to other males. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MLKMAKVEPVERYCKVIRMIRFCVGFCGNDVADPNFRMWWLTYAVMAAIAFFFACTGYTIYVGVVINGDLTIILQALAMVGSAVQGLTKLLVTANNASHMREVQNTYEDIYREYGSKGDEYAKCLEKRIRITWTLLIGFMLVYIILLGLVITFPIFYLLILHQKVLVMQFLIPFLDHTTDGGHLILTAAHVILITFGGFGNYGGDMYLFLFVTHVPLIKDIFCVKLTEFNELVMKRNDFPKVRAMLCDLLVWHQLYTRMLQTTKKIYSIVLFVQLSTTCVGLLCTISCIFMKAWPAAPLYLLYAAITLYTFCGLGTLVENSNEDFLSVIYTNCLWYELPVKEEKLIIMMLAKAQNEVVLTAADMAPLSMNTALQLTKGIYSFSMMLMNYLG
The following text describes a protein:
Function:
Magnesium transporter that may mediate the influx of magnesium.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MLLSMENRATFSTESETEAEIRKEALRPFAQNRQHSEKGSLEGPAPKYKVWKVTRDGRKTEEEIPQEALGLPPRDLDILSSVTFTPHRAQIGARGGKMLVRMENLRALIAPEEVIFFGGRFARSAATCAELAASFLAQHPQGGSQFPFELRMLECILRETRTYFVHKIAKLKMVAEAMLEDLASDISTAGLHLRLLPLKRTMTEVDNDVRETYEALTEVIENDTLLMDLCRTVDEGSEGAERAGNEAGGSGRKRAVVAMLLSYQREVQDVGSALKELRENMDSAQAVWELGLDSTRNRIIKMNLYIGMATLSASCAQLPAAFFGMNVPSGLEEAGGLFPYITGAACAASLGLFGYCLYWYKFRPQRKHQRRLQDIAALRDLLHHIDDLDDIIKKGMGKRPHVNEQEFTEILRNHPATAQLNKGSVALIFRMLDQNKNHCIDVEEFGRALDSPTTYKNSQQIQ
The following text describes a protein:
Function:
Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).
Sequence:
MLEQLKETVFKANLYLPKYQLVTFTWGNVSGIDREKGLVVIKPSGVEYFEMKSKDMVVVDLEGNIVEGDLKPSSDTPTHLALYRAFDKVGGIVHTHSVWATAWAQAGKEIPAYGTTHADYFHGTIPCTRPMTETEILGDYEKETGNVIVETFRNKDPMSIPGVLVHSHAPFVWGKDPMEAVHHAVVLEEVAKMAQKTLSISERTLPMDSVLLDRHFYRKHGQAAYYGQEKR
The following text describes a protein:
Function:
Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
Subcellular Localization:
Cytoplasm.
Sequence:
MFQDNPLLAQLKQKIQETLPKKEGTIKASDKGFGFLEVDSKTSYFVPPPYMKKCMHGDKVVAFIRTENEREVAEPSELIEQSLTRFIGRVKLFKGKLNVAPDHPQLKKLSLKAKTKKGLNEADFQEGDWVVAHLVRHPLKGDDGFFVQISHKITDANDKIAPWWVTLAENDLPNSEPAGIDDWQLKDDADLVREDLTALPFVTIDGESTKDMDDALYAQQLPNGDFALTIAIADPTAYITPEDEMDKVARERGFTIYLPGRNIPMLPRDLADELCSLMENQVRPALCCSVTIRKDGVIGDDIRFFAANIKSHARLVYDHVSDWLETGSSEQWQPSEEIAQVVRDLYAFSQARANWRETHAVVFPDRPDYRFELSADNDVVAIHADMRRTANRLVEESMITANICAGKTLQTTFGFGVFNTHAGFKAEKMADVVELMAVNGAPNADAETLATVEGFAALRRWLATQETSYLDNRIRKYQSYSEIGNQPLPHFAMGLDVYATWTSPIRKYGDMINHRLLKAHILGKAPVQTPDETVGEELALHRKHHKIAERNVADWLYARTLADEPAKETRFQAEIFDINRPGMRVRLLENGAMAFIPGALILDNKERIECNGEDGTVLIDKEVVYKLGDVLEIVLTEVNQENRSLVGKPTQVFADLVSETQTSAEQPAEGAENNEPQV
The following text describes a protein:
Function:
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MRGGRARPAWESFMGLPPRSSAKWGAGQSLDRLCCAPGGRGLAGAPGRMRAPPAGRPQPAGGPGDSLPHPPGGLGPGGSAWARRAEAAASRARGGGRGGPGITWAEAGPGAPGGLSPESGRRQRERXXXXXXXXXXXXXXXXTGERQPGERVHLRLSARPALPGAGLLSAPLSARNPGLVRGPAPRSLASAGAPPRAALSPAGALLLQPPARRVLCPRSEGGSRTGRAGPSGWAPPRGARSAECTDRLKGMALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSVRSSYSSPTSLSPRACSPFSPPPSSSPLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPATLSSRA
The following text describes a protein:
Function:
Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT).
Sequence:
MTDLKTTFAGLSLRNPIIISSSGLTNSAGKNKRLAEAGAGAIVLKSLFEEQIMLEADQLKDPAFYPEASDYLEEYIREHKLAEYLTLIKESKKECSIPIIASINCYSDSEWVDFAKQIQEAGADALEINILALQSDVQYTYGSFEQRHIDILRHIKQTVTIPVIMKLGDNLTNPVALIDQLYANGAAAVVLFNRFYQPDINIENMEQVSGEVFSTSADLATPLRWIGIASSVVNKIDYAASGGVANPEAVVKAILAGASAVEVCSAIYQNTNAFIGESTRFLSAWMERKGFKNIAQFKGKLNIKDVQGINTFERTQFLKYFGKKEA
The following text describes a protein:
Function:
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix. Cytoplasm, perinuclear region. Note=Expressed in the perinuclear region of the oldest most anterior lamina neurons at 24 hours after puparium formation.
Sequence:
MVRATGTRMGLLLPIILALAIGSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCEQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKLNLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAAPGYLAIGPSSVVLEWKDEWSLRMKRFQRRARKCS
The following text describes a protein:
Function:
Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRRKQAKPQHINSEEDQGEQPPQQPAPEFADAAAAAPAAGEPGAPMNHPGTGSEANRDGMTAKRTRREETHICEKCCAEFFSFSEFLEHKKNCTKTPPVLIMNDSEGPVPPEEFPGAALGHPPHSPGGKEGHREDGGGSGELKEKLGAESVVYLKAETALPTASQDISYLPKGKVANTNVTLQALRGTKVAVNQRSAEAPPAPVPGASSIPWVLEQILCLQQQQLQQIQLTEQIRVQVNMWASHALHSGVAGADTLKTLGSHMSQQVSAAVALLSQKAGSQGLSLDALKPAKLPHANIPSTASSQGLASFALKPDGTRVLPNVMSRLPGALLPQAPGSVLFQSPFSTVALDPSKKGKGKPPNVSPVEAKPKDEAILCKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQVKANPQLFAEFHDKMTAGNGIPYALSVPVPVDESSLSLDSKPVLVTGTPGLGLPQNLSSGTNPKDLLGGPLPNDLQPGPSPESEDGSLLSGGGPNHTSPRVGGFQGSGTPEPGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVLLQQHIRMHMGGQIPNTPLPENPCDFAGPEAAMVSENGSAGATCHDDVIESIDVDELGPQDASGSSLKVPVPLPSVHSASPTLGFAVTAALDAPGKVGPAPLVLQRQSSRENGSVESDGLTNDSSSSVMGDQEYQSRSPDVLETASFQALSPANSQAESIKSRSPDAGGKADSSENSRTEMEGRSSLPSTFIRTQPTYVKVEVPGAFVGPATMSPGMTPLLTAQPRRQAKQHGCTRCGKNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNSSARRGRKLAIENTMALLGTDGKRVPEMFPKEILAPSVNMDPVVWNQYTTMLNGGLAMKTNEISVIQSGGIPTLPVSLGASSIVNNTTISKMDGSQSAISAEVEKPGAADSVPKHQFPHFLEENKIAVS
The following text describes a protein:
Function:
Regulates chromatin compaction in spermatid nuclei and is essential for male fertility. Functions in parallel with other chromatin-condensing proteins such as ProtA, ProtB and Mst77F.
Subcellular Localization:
Nucleus. Chromosome. Note=Expressed in mature sperm chromatin.
Domain:
The C-terminal part (169-201) is essential for male fertility and correct chromatin compaction in mature sperm.
Sequence:
MGRKRGRKEYCPPIYKRQKVARVTNNGYLNFMTEYKKRFYGLSPQDMVHYAAKQWTQLSMAEKEAFKSKKPSTITLKSPAQYVACEMKSDVAGGQQSSCQRQSPSARLRESERRSSRSKTLCRSAKNRQRGKPKPQQSKRRLSHMGSAVAYIHFLRKFQRKNTELRTIDLLKTATRLWCRLPERHRHAFERPLWIVTIGKS
The following text describes a protein:
Function:
Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTIKQKSSFGAVIVLLIGTILWAVQAGSLSMSIPAFLSGIFSGGNEMVDVVIDLRFPRIIIALLAGAALSVSGLLLQAVMRNPLADAGVIGISAGAKFFSFVIILFLPELYFWLPLFSFIGGALACFLVFLFSYRSDFNPLRFIIIGIAINAVFTGLSDALSSQVALVSSQSASSAASLAMKKWSDVETLLIYVTIGLICALLLAKWCNVLGLENKMARGFGVPVNKTRIWLALIAVLLASITTAVVGVIAFVGLLVPHIARKLVGGNYQILVPFSILFGALLLLFADTIGRTLFQQMEIPASVIMLIIGGPFLIFLMRKGDFYGSKGR
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPSEGSQQPSLDSFFKRKNPRVEPYSRTGNNAIIDLTDSPPNKKIKLDDEGSQKNRSMTQTSSSYFKGHPTARPLSVDKRLPRKPSAAIQAYKLQDVIPPQPSHSGLAFETCSLVPQASFVPDSQPEPSASPAPQRTTEQLKRHEEWKTRILAMSGSFRRKRSLALDEAVAAEAREAAGLEDEGTPFDGSDGDDYKSESEKNAEEVGKQLKKYVAKELAGKGKSKGKKKEEIGPSGLAYTPLEKQFMEIKEQNRDVLLLMEVGYKYKFHGEDAKTASRELGIVAFPNRNFFTASIPTHRLHIHVKKLLSLGYKVGVITQTETAALKKIGDNRNAPFARKLTHLFTAATYVEDPSLSSSSSSSSSVRFDDPVVPGTAPPPTNALVAIVEQPVDRASDDRVKVGLVCVVPGTGDITWDEFDDSQIRTELETRLAHLSPAELLLPKQRLSKATEKVLTYFAGEPKHRGRNAVRIERIDNIPEYDAAFDFLTNFYHCKEHKATVSKGDVNDERHLMTEGNKQWSLQPKLSQDGADISLDEEIYLASGVSSSKAILTLVDFPKQVVISMAVAIRYMKRFGLENAFKHTSSFVRFANRSHMLLSSNTLANLEIYQNQTDGGLYGSLIWLLDHCKTRMGKRLLREWVGRPLLDVAALKARADAIEEIMENNSYHMEKLRSLLINMPDLVRGLTRVQYGKATPNELATLLITLVRLASEFKPNMGNVFRSCLLNNIPNTLPTILDTSQRFLNALNLKQARENDVANLWADPDRFPDIQDVKDCISVCEMELNEHLMELRKILKKPTLRYITVSGIEYLVEVPIRDTKIVPAQWMKISATRTVNRYHTPKILAITKERTQHLEKLSIVAREAFIAFQSEVAEYHELVVVSKQIAVIDCLMSLAQTAAASGYCKPKFVAEPELKILAGRHPMVEMLREESYVPFDIHFSKEEGTTKIITGPNMAGKSSTVRAMALIVCMAQIGSFVPAASVTLSVHDSVQTRMGASDEIGRGKSTFMVELSETSDILQTITPRSLVVLDELGRGTSTYDGIAIAYATLSHIAEIGCNTLFVTHYPTVAQDLAREKPDKISNWHMSFDEIQMPDGGAEITFLYQLTRGLQEASFGVWCARLAGLPKPILDTAQMRSSSLKAETQERLRGIVARRVGWMLHNLFDNKTSSSQVLRNVEMLHNSLSSSSISFSQ
The following text describes a protein:
Function:
Probably inactive kinase. Component of the AP2-containing clathrin coat that regulates clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. Together with SCYL2B, required for cell growth, plant growth and development.
Subcellular Localization:
Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Prevacuolar compartment membrane. Note=Colocalizes with the clathrin heavy chain 1 (CHC1).
Domain:
The protein kinase domain is predicted to be catalytically inactive.
Sequence:
MSINMRTLTQALAKTAAVIEKTVQTTVQEVTGPKPLQDYELLDQIGSGGPGLAWKLYSAKARDSTRPQQYPTVCVWVLDKRALSEARARAGLSKAAEDAFLDLIRADSGKLVRLRHPGVVHVVQALDENKNAMAMVTEPLFASVANALGNVENVDNVPKDLKSMEMSLLEVKHGLLQIAETLNFLHNNAHLIHRAVSPENVFITSAGSWKLAGFGFAISQAQDGNLDNLQSFHYSEYDVEDSILPLQPSLNYTAPELVRSKTSSAGVSSDIFSFGCLTYHLVARKPLFDCHNNVKMYMNTLNYLTNETFSSIPSDLVSDLQRMLSMNESYRPTALDFTGSSFFRSDTRLRALRFLDHMLERDNMQKSEFLKALSDMWKDFDSRVLRYKVLPPLCAELRNLVMQPVILPMVLTIAESQDKNDFELTTLPALVPVLSTATGDTLLLLIKRAELIINKTNAEHLVSHVLPLLLRAYNDNDVRIQEEVLKRSTSVAKQLDGQVVRQAILPRVHGLALKTTVAAVRVNALLCLAELVQTLDKLAVTEILQTIQRCTAVDRSAPTLMCTLAIANAILKQYGVEFTSEHVLPLIIPLLTAQQLNVQQFAKYILFVKDILRKIEEKRGVTVNDSGVPEVKPGCVADGLQFQTPTKKTEKVASAAKNSPAWDEDWALPTKISAPRDPGPANSPQFNNSTVQSQSSNRTSVPTTCPAVDLEWPPRQSFNATAQPANDETRINAAGTPTTPSFDELDPFANWPPRPNSASTASGGFHNSTTTQPPINNSGSGLRNNLTDGRQFQTTNNDFWAFGNASLSSMKSQQETSGIRASNADPLTSFGIQNQNQGMPSFGSSSYGNQKPQADISSIFSSSRTEQSAMKLAPPPSIAVGRGRGRGRSGTSISKPNGSKQQQTEQPSLLDLL
The following text describes a protein:
Function:
Catalyzes the hydroxylation of n-alkanes and fatty acids in the presence of a NADH-rubredoxin reductase and rubredoxin. It preferably hydroxylases C5-C12 hydrocarbons.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSENILTEPPRSDADNEGYVDRKRHLWILSVLWPATPIIGLYLVSQTGWSIWYGLVLILWYGLVPLIDTMLGEDYSNPPESVVPKLEQDRYYKVLTYLTVPIHYAALIISAWWVSTQPIGVFEFLALALSLGIVNGLALNTGHELGHKKETFDRWMAKLVLAVVGYGHFFIEHNKGHHRDVATPMDPATSRMGESIYTFSLREIPGAFKRAWGLEEQRLSRCGKSVWSLDNEVLQPMILTVVLYAALLAFFGPLMLIFLPIQMAFGWWQLTSANYIEHYGLLREKLPNGRYEHQKPHHSWNSNHVMSNLILFHLQRHSDHHAHPTRSYQSLRDFSDLPTLPTGYPGMFFVAFFPSWFRSLMDDRVMEWAHGDINKIQIQPGMREFYEQKFGVKGSESPDTTVAK
The following text describes a protein:
Function:
After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MWVPSIILLLLTWILRPVYTPNSSYAVVVDAGSTGSRVHVFKFRHETNQSLPILEDKYFEFTRPGLSSFATEPQLGAETLRGMLNRATNWIPSKHQTETPIWVKCTAGLRMLTPEEQVGILTSVDNLLTEYPFQRSAEAVAVLTGEEEGFFAWMTLNYLLGRLQHNRTVSVAELGGGSTQIVFEIERNKGGCSSMAVGDDERKFDLYQYSHLGYGLMEARKKIFELNNGRINPCIGKGMSKVINGKTEAGYELTSDVLNDQECIAYMEKILHTEPCTHSSCSINNVYQPPIGTYNGDLYLISYFYDRTSNLGLQNEFSLRDVKRLQEKVCHGQWTDISGLSEMAFKELQGRPEWCLDLSFMYTLLHSGYGIALDRPLKTVKSHGGNEVSWALGVALQNAAGY
The following text describes a protein:
Function:
Part of the ABC transporter complex OppABCD involved in the uptake of oligopeptides. Peptide-binding protein that shows broad specificity but a moderate preference for hydrophobic oligopeptides and those that are 6-16 amino acids long. Can bind the tripeptide glutathione (GSH) and the nonapeptide bradykinin. Glutathione (GSH) uptake by mycobacteria through the OppABCD system contributes to the depletion of the GSH pool in infected macrophages, which impairs the ability of the macrophage to detoxify methylglyoxal (MG) and contributes to enhanced production of inflammatory cytokines.
Subcellular Localization:
Periplasm. Note=Attached to the external side of the transmembrane subunits OppB and OppC.
Sequence:
MADRGQRRGCAPGIASALRASFQGKSRPWTQTRYWAFALLTPLVVAMVLTGCSASGTQLELAPTADRRAAVGTTSDINQQDPATLQDGGNLRLSLTDFPPNFNILHIDGNNAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTRTAPQVVTYTINPEAVWSDGTPITWRDIASQIHAISGADKAFEIASSSGAERVASVTRGVDDRQAVVTFAKPYAEWRGMFAGNGMLLPASMTATPEAFNKGQLDGPGPSAGPFVVSALDRTAQRIVLTRNPRWWGARPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAARTKGISIRRAPGPSWYHFTLNGAPGSILADKALRLAIAKGIDRYTIARVAQYGLTSDPVPLNNHVFVAGQDGYQDNSGVVAYNPEQAKRELDALGWRRSGAFREKDGRQLVIRDLFYDAQSTRQFAQIAQHTLAQIGVKLELQAKSGSGFFSDYVNVGAFDIAQFGWVGDAFPLSSLTQIYASDGESNFGKIGSPQIDAAIERTLAELDPGKARALANQVDELIWAEGFSLPLTQSPGTVAVRSTLANFGATGLADLDYTAIGFMRR
The following text describes a protein:
Function:
Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity); [CD40 ligand, soluble form]: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein. Cell surface; [CD40 ligand, soluble form]: Secreted. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Sequence:
MNEAYSPAAPRPMGSTSPSTMKMFMCFLSVFMVVQTIGTVLFCLYLHMKMDKMEEVLSLNEDYIFLRKVQKCQTGEDQKSTLLDCEKVLKGFQDLQCKDRTASEELPKFEMHRGHEHPHLKSRNETSVAEEKRQPIATHLAGVKSNTTVRVLKWMTTSYAPTSSLISYHEGKLKVEKAGLYYIYSQVSFCTKAAASAPFTLYIYLYLPMEEDRLLMKGLDTHSTSTALCELQSIREGGVFELRQGDMVFVNVTDSTAVNVNPGNTYFGMFKL
The following text describes a protein:
Function:
Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of ribosomal proteins (RPL11, RPL16, RPL25, RPL31A), the poly(A)-binding protein PAB1, the HO endonuclease or the tRNA and snRNA chaperone LHP1. Indirectly involved in nuclear mRNA export through its PAB1 nuclear import activity.
Miscellaneous:
MISCELLANEOUS: Present with 16300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus, nuclear pore complex.
Sequence:
MVQEQAILSCIEQTMVADAKIIKEAEQQLFEFQKQPGFTSFLLNIVSDDNFALNVRLSSAIYLKNKIHRSWDTKREDGIKADEKLSIKERLIETLVKNCENNHIRPILTETINGILVGQEDWDLAPIIKNLLSSGDASYIYPGLLLLFQLCKAHRWDMVGSRDYIDSVIEELFPIVEGIASNIGSQTDYRSNEILYLILKSFKYACLNNLPQYFSQPERIMSWVQLHLYLCSKPLPVEVMELDPADRSLDKRVKVNKWGFGNLNRFLQRYNKITKAITKEFIDYIFNTIVPIILREFFKDIEAWGNNSLWLSDSSLYFLISFLEKCVTIDQLYPLIEPHLQIIFENVIFPCLCANEQSIELLEDDQEEYTRRYFDINREGSTPDAASADFIFLIGSKRPEKLNNILPFINDIFTRFDANSSDINMAFKEEGALRTLSNLFSFIDEPSVLENIFGHFIVPLLSQDKYMFLVARSLETIALYSEEFKDMNILSQLFELTYTNFLNSNVLPVQIEAADAIKCLIVSNPQIHPAVSAHVPGMMEKLLKLSKIFEIDILSEVMEALVERFSDELSPFAKDLASNLVEQFLRIAQALVENPSETYSASDQEQEIQASGLLQTMTTMVMSMNKVPLIESLAPVVKFVVLHAQISFITEAVDLLDALTISSHLLYNQIAPPIWELLHDILDSFQTYAMDYFEAYSIFFETIVMTGFPQDQTYVQPLLEILSAKLESEVDYDIEHVMQILMYFALSMRDIPLFSKAIKVSTNDELGLDSKCIVKLGLANLFAKPIETLQIMENEGFTINFFTNWFNEKFYSVFAIKLQVLVILTLLKMPEVPNSVSPLLNNLTNKLVELTLSLPKAIRNRDAVTEGKSLEGDLTPEEEEEYFIECDDDMKETVLDQINVFQEVHTFFKNLQNEDAGKYEKIINYLDESKRDSLQVILEFVSQH
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Accumulates predominantly in the cytosol. Exported from the nucleus in a XPO1/CRM1-dependent manner.
Sequence:
MGPRKKSAKVCVMDSEVAEEMTADEEKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDSSFLTLLKKMPDVEQLYGLHPRYLERRRVRGQEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWMRLVDINLVRCHALKLDSFGQFVELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAPNNNANLHDNNHHHPDDSDDDNDFRPDLQAGEAQFAADALNEMEDMVQEDGELVAESGNGMPAHNREVLPVDADEEQAGPSGLQRVVKPTPIADHDSESDDEEDSLELQEVWAPKNGTRRYSEREEKTGDSGQSRETAVSGKGKTPLRKRCNNSHQTGQAKPFPLEESSCEKGCQVTSEQIKADMKAARDVSEKKKSKDVYPSCSSSSSSTAASTAGNASSPSTASQSPDFARTVTSSGSSEPSPPEVDVSRQCVCSPGGSEDSEAMEEGDAESSVCPRCCCLRPQESQRRTGRCSDEERPSTSRACVVNGADGTRSAFSFRTLPQGGSSGPAHDERTNGSGCGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVPLISESEVAKTKPCHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRNWMDTIANINQELIKYEFFLEATRTEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRTAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKRGIFQRVVAIFIHYCDVNGEPVEDDYI
The following text describes a protein:
Function:
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MNVPSSAERWRSAMLYAWVSAGSVVGGLTRYLVGLALDTGPGFPFATLFINATGSLIIGFYATLTGPDGRMLARPEHRQFVMTGFCGGYTTFSAFSLETFRLFHGGMKYIALAYVASSVVCWLVSVWLGHIMASRYNRLKRS
The following text describes a protein:
Function:
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNTTSPAAPSSSGVSFISLLVIIVLSVALAVGLPGNSFVVWSILAKLRKRSVTALMVLHLALADLAVLLTAPFFLYSVAQGTWTFGLSSCRLFHYVCGVSMYASVLLIMTMSLDRSLAVALPFVSQKLRTKAVAWRVLAGIWVMSVLLATPVLLYRTVHLGLNNRSLTCFLKYPSERHRAFHLFFEVITGFLLPFLVVVASYCDIGRRLRARRFRRSRRTGRLVALIILAFAAFWLPYHVVNLAEGFRAAAGKALGSGPVGRRLLLARHVLITLAFLSSSVNPLLYACAGGGLLRSAGVGFIAKLLEGTGSETSSSRRKGTLAQTLRGTPASPEPDPAESLTASTNPLE
The following text describes a protein:
Function:
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
Miscellaneous:
MISCELLANEOUS: Was identified as a high-confidence drug target.
Sequence:
MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAAGMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQHDFGLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAPLSTAAGGGGRQPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDIPWLVIRALSDLAGADSGVDFNRFVGEVAASSARVLLRLLPVLTAC