lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular Localization:
Nucleus.
Sequence:
MADAQLFEENFIVTKVNKEKYDRVHRLSGTSTDGSLTFTLDINHELWPVAEGSTINIVLATTLALDGTTKEGAETSWRNVSRSNTATLADLFEYVCYGKNYRFEDAEAGAETVKYYASFGGMLLYIEGPYRKLNGLKIDEIYMLCKKA
The following text describes a protein:
Function:
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular Localization:
Membrane.
Sequence:
MKVTVDGVPLDLPAGTSGIDAVFAAGRDVPYFCAHSYLSPVGACRMCLVESGSPRKGKDGNFELDEQGEVKIFWFPKPMAACTMQATEGMHIKTAATSEVVAKSQAGMMEFTLLNHPLDCPTCDKGGACELQDRAFEYGYGASRFGFDRRHADKHYPLSDFVILDQERCIHCKRCVRYFEEVPGQEVLDFIERGGHTFIDTQEGGLPTGFSGNITDICPVGALLDNVARFRGRNWEYDHTPTTCTLCPVGCAITVDARNGRLERIVGRENRDVNEIWLCDAGRFGHTFASEGRLTRPLIRENGRLREADWDEAIAAMRRGLSGIHPSQLGLFIAADSTLEEGMALERFAAQLGAGNVDHWPRHPVQLTAPAATLTDVAQADALVVIGADLGEEAPVLELRILEALRGGILPTEFDHGTAIADLRLVERPARKPEKLAVIGRESSIWRHAGIQAASNGHNAVARLLRPDTDELRAALKLLEEAEKPVVILGADVLGADVLGSGTDGLAAQVSELANRTGAKVLAVAAAANSTGLAALNLLPRSGAAGYAGLTDAPAAFLSRLDPVGQGLLSLPRGFTVVHDTHLTETAQQADVVLPAVTNYEKRGTTVNLEGRFLALEQAALSAGEGADLIRTLTALAEALGVRPQVRGLKSAQAALQERLGLRVDTLPPQGALNLNVNRAAAPVGVPYTPQLWKPRMRPAPQASEQPDLGRGQASWAAPLSAAAPTGGDD
The following text describes a protein:
Function:
Functions in the engulfment of cell corpses during embryonic programmed cell death to translocate molecules that mediate homotypic adhesion between cell surfaces of the dying and engulfing cells.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Domain:
Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Sequence:
MNRLRQFSLLLWKDWVLLRRNKVWTLFELIIPCLLLGPLVYLVVKNADHTSSPENIYDNFQVKGTVEDVFLESNFIKPIYKRWCLRSDVVVGYTSKDAAAKRTVDDLMKKFAERFQSAKLKLSVKNESSEEQLLTVLRNDLPMLNETFCAINSYAAGVVFDEVDVTNKKLNYRILLGKTPEETWHLTETSYNPYGPSSGRYSRIPSSPPYWTSAFLTFQHAIESSFLSSVQSGAPDLPITLRGLPEPRYKTSSVSAFIDFFPFIWAFVTFINVIHITREIAAENHAVKPYLTAMGLSTFMFYAAHVVMAFLKFFVIFLCSIIPLTFVMEFVSPAALIVTVLMYGLGAVIFGAFVASFFNNTNSAIKAILVAWGAMIGISYKLRPELDQISSCFLYGLNINGAFALAVEAISDYMRRERELNLTNMFNDSSLHFSLGWALVMMIVDILWMSIGALVVDHIRTSADFSLRTLFDFEAPEDDENQTDGVTAQNTRINEQVRNRVRRSDMEIQMNPMASTSLNPPNADSDSLLEGSTEADGARDTARADIIVRNLVKIWSTTGERAVDGLSLRAVRGQCSILLGHNGAGKSTTFSSIAGIIRPTNGRITICGYDVGNEPGETRRHIGMCPQYNPLYDQLTVSEHLKLVYGLKGAREKDFKQDMKRLLSDVKLDFKENEKAVNLSGGMKRKLCVCMALIGDSEVVLLDEPTAGMDPGARQDVQKLVEREKANRTILLTTHYMDEAERLGDWVFIMSHGKLVASGTNQYLKQKFGTGYLLTVVLDHNGDKRKMAVILTDVCTHYVKEAERGEMHGQQIEIILPEARKKEFVPLFQALEAIQDRNYRSNVFDNMPNTLKSQLATLEMRSFGLSLNTLEQVFITIGDKVDKAIASRQNSRISHNSRNASEPSLKPAGYDTQSSTKSADSYQKLMDSQARGPEKSGVAKMVAQFISIMRKKFLYSRRNWAQLFTQVLIPIILLGLVGSLTTLKSNNTDQFSVRSLTPSGIEPSKVVWRFENGTIPEEAANFEKILRKSGGFEVLNYNTKNPLPNITKSLIGEMPPATIGMTMNSDNLEALFNMRYYHVLPTLISMINRARLTGTVDAEISSGVFLYSKSTSNSNLLPSQLIDVLLAPMLILIFAMVTSTFVMFLIEERTCQFAHQQFLTGISPITFYSASLIYDGILYSLICLIFLFMFLAFHWMYDHLAIVILFWFLYFFSSVPFIYAVSFLFQSPSKANVLLIIWQVVISGAALLAVFLIFMIFNIDEWLKSILVNIFMFLLPSYAFGSAIITINTYGMILPSEELMNWDHCGKNAWLMGTFGVCSFALFVLLQFKFVRRFLSQVWTVRRSSHNNVQPMMGDLPVCESVSEERERVHRVNSQNSALVIKDLTKTFGRFTAVNELCLAVDQKECFGLLGVNGAGKTTTFNILTGQSFASSGEAMIGGRDVTELISIGYCPQFDALMLDLTGRESLEILAQMHGFENYKAKAELILECVGMIAHADKLVRFYSGGQKRKISVGVALLAPTQMIILDEPTAGIDPKARREVWELLLWCREHSNSALMLTSHSMDECEALCSRIAVLNRGSLIAIGSSQELKSLYGNNYTMTLSLYEPNQRDMVVQLVQTRLPNSVLKTTSTNKTLNLKWQIPKEKEDCWSAKFEMVQALAKDLGVKDFILAQSSLEETFLRLAGLDEDQLDTHSTVEISHSTHV
The following text describes a protein:
Function:
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Sequence:
MVYPAGQLADAPSQAQGGIIFRDLRSTDRATRPAASAQSSPQQTRLTIVDNLLKQFAQSSQLAGGNAAYIEDLYEQYLVAPDSVDPKWKAYFDGFNGRDAGDVPHSAAIAHILSASKQAANAGTGVGASDERERNVGRLITAYRSRGHLGAQLDPLGLTPPVNPPDLDLPFHSLSQADLDSEFSTGGVGGQPRMKLKDLLARLKATYASTIGAEFMHIPEFDQRQWIYKRLEDAGGKIAADAASRKRTLERLTAAEGLERYLHTKYVGQKRFSLEGGDALIPMMDTIIRQSGNDQVKDIVIGMAHRGRLNVLVNTLGKNPRKLFDEFEGKFEHAHDDRAHTGDVKYHMGFSADIAVGDDKQVHLALAFNPSHLEIVDPVVVGSVRSRQERFGDADRKTVLPILIHGDAAFAGQGVVMELFQMSQARGFAVGGTVHIVVNNQIGFTTSARDDARSTLYCTDVAKMIGAPVFHVNGDDPDAVMFVSKLAYEFRQQFKKDVVIDLVCYRRWGHNEADEPAATQPVMYQTIRKHKTTRELYATKLESDGVLSADEAKALVDGYRNKLDSGEYTTELAKRKPDEFAIDWSKYLVGTAADPVDTRVKRNELDRLAKLITTIPAGVELHARVAKIYEDRVKMAAGNQDGDWGFAENLAYATLLAEGHKLRLVGQDAGRGTFFHRHAILHDQKTDSYYLPLRQLVENPEDATIIDSLLSEEAVMGFEYGYSTTDPNALCVWEAQFGDFANGAQVVIDQFIAAGEAKWGRIAGLSLFLPHGYEGQGPEHSSARLERFLQLCALENMLVCVPTTPAQCFHMIRRQMRMTTRKPLVVMTPKSLLRHKLAVSTLEELADGQFQHLIPDAKADASKVKRVVLCSGKVYYDLLEDQTKRGQDDVAILRVEQLYPFPRAQLAAELKRFGNAADVVWCQEEPQNQGAWYQIRHHLNFCLASGQSLHYAGRARSPSPAAGHMADHIAEQQKLVADALLNPFNDQVAE
The following text describes a protein:
Function:
May be involved in maintaining Golgi structure and in intra-Golgi transport.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MLQTGDAIQNARDSAPRTRKSSTASVSATIISMPEHVITEDFGRPAPSLPSRAQSDYTGAGWRGGRNYEQGSSSTHQPGVTAASESWTMVLNSKEVKNAKPDEDTRSQRSVGGRSVASIRTTSEFAGNDSSPNFKSQLFAKDSQISVLKTKLSEVERKFEKRSQDYYEMKAEKEMLEKRVENQKVSSHEMDSLQELKLARQKAQDQKEKAVEECNMHKRKIVGLEEEIRAMVEQLRLAKFNLNENKKEFDEYKNKAQKILTAKEKLVESLKSEQGIGSSDRPVHLLQAEVEEIRVERDLTKADLESAQLQVYTLRSDMEELEAQIRDLQSQLSDQKRTHLEEKQTWDSTIGLLNEKVECSRIENEFTKQEMKRQGDQHQSKMLEKENELRKTISDLRSRMRDEQTKQEDDGSSQLTDLLLQKQQQLEDVLRNNQVLNVRLERLQKATNRETSIAVDSNSSPMHTSSSHPLLSNINNPQTRNALHTVDSTAFKLLSMLRGHPSARLFFVLYFIIMHLWLFFIVLTYTPEIH
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MNENSMEFFLPDLNATDQWGQQLAQQLPLGTIILLQGDLGAGKTSLVQGLGRGLGITGEIVSPTFTIVNEYREGKMPLYHLDLYRLNTLEVEYLYPEQYWQGEDFPLGITAVEWPERLPQLPSQYLQIQLCHQGEGRSIALTAQDWAMDLKELLPPS
The following text describes a protein:
Function:
Role in flagellar biosynthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Sequence:
MELLLDTLMQTIASYMWPLFRVASMLMVMVVFGAATTPTRVRLLLAIAITLAIAPVLPPVKDAQLFSLSAVFITAQQIIIGVAMGFVTQMVMQTFVLTGQIIGMQTSLGFASMVDPSSGQQTPVIGNFFLLLATLIFLAVDGHLLMIRMLVASFDTLPISNVGLTLTSYRSLAEWGSYMFGAALTMSLSAIIALLLVNLSFGVMTRAAPQLNIFSIGFPITMIGGLLILWLTLTPVMAHFDEVWASAQLLLCDILGLQCQADGIL
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MEAKGASASRTLSGDVSWKPNWRRELRSSPGGSSSTTISHPLDPQQEKKLDFVMRLFDDFCVANGDASSVLELWLPEMAAVSRRRHVVAGDPTSLLQFAGSWVGALTGIAESIRNAYLAAMFSVPEGGPVHMSPFVDAVVAPYSSCSITHGGGESEIIVVADGAPSPTAQPLIGVREAVSRASQDIRLSFCSTSSVEAKMITQMRWPASCYRKQASWIWSIIQEVRAHLLPSTELEVDDGPCLLSANCATVYRIVGQFAARFPGYVPTIDSMSPLNSLIMETVSGLDEKLAEKSRSFPDQSLRFLFLINNSYFIWQHLYPISVPEVNNFLEVKIDNYVQTYLQVSWEPSEFQKTYNAQKFWKVPDPKLRRRLRVAIIEEVVSSFTKYLEYNDIIPSRITPHDLMDMLQELFEG
The following text describes a protein:
Function:
May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.
Sequence:
MNVQPCSRCGYGVYPAEKISCIDQIWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAHNPKNNTFTSVYHTPLNLNVRTFPEAISGIRDQEDGEQFKSVFHWDMKSKDKEGAPNRQPLANERAYWTGYGEGNAWCPGALPDPEIVRMVEARKSLGEEYTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEYKRGHDERISRFSTVADTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSFPAMITPAYQIAKRANELASDVRYHQQYQKEMRGMAGPAIGAEGILTRECADQYGQGYPEEYEEHRGKGSFPAMITPAYQNAKKAHELASDIKYRQDFNKMKGAAHYHSLPAQDNLVLKRAQSVNKLVSEVEYKKDLESSRGHSINYCETPQFRNVSKISKFTSDNKYKENYQNHMRGRYEGVGMDRRTLHAMKVGSLASNVAYKADYKHDIVDYNYPATLTPSYQTTMKLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIKYKEEYEKTKGKAMGTADSRLLHSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNIRHAKKAQALASDLDYRKKLHEYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMKGVGWLTEGSLNLEQAKKAGQLVSEKNYRQRVDELKFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDEPLFLQARANAANLSEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEVKYKEDYERSRGKLIGAKDVQGDSQMSHSLQMSKLQSELEYKKGFEDTKSQCHVSLDMVHLVHARKAQHLATDIGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGTGWVATGSLNVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENIKHHYTLTADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKASGEIISDYKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFHLPLDMAALVHAKKAQTLASDQDYKHPLPQYTSLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGVACVIPGTLEIEGRKKASELISESKYRQHPHSFKYTAVTDTPNLLHAKFSNQITNERLYKAAGEDARHQYTMTLGLPEFIRAKTNAANLSDAKYKESWRNLRAQGYKLTIEALPFQAARASGDIASDFLYRHDFVKERGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRRATSSQAQFHLPMDMVHLVHAKNAQALASDHDYRTQYHKFTALPEDLKMAWAKKAHALQSELRYKSDLIGMKGIGWLALRSPQIESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAKNSYMHCNERMYRSGDAESLHRYTLIPDHPDFTRARLNALHLSDKVYRNSWEQTRAGSYDFRLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQSDNEYKKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQLGLRHAQKAHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANARGLGLQGAYQRGAEAVEAGEHQSREVNPDATEILHVKRKKALLL
The following text describes a protein:
Function:
Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center.
Sequence:
MGGAGYNMGGVGRKCWGTIQIGPCAAQLIRVSSRADSVVRGVLRMLQGFSGPPFFWDKNANIFRAKSGVYVSHLSQKSLHSLLNQFIHAATCLQLVAITLNKVETAVPKSPPTLNAFVCLKGLRNIALKEETSTSNADCVTTPTLLGLANSLSSLCSGAEFLFGVVHEAIPAVYFEFGLSVPAAELTVHVLDYLHKKLDEVCLVQGGEEAYQMVLYMYVGSLLPYIEGLDSWLFEGILDDPFGEMSFFTDKEVSVDEAEFWEKSYLLRRLQHSKLDSEFFSSTNYVNDPVPASNDKEMDRRIPSLCLVQMAGLTLPEGFSVSLVGFVGHGDHVCKYFWQNNWYESVSFSSNVSHVNEEKPDNDNNEKLIAPPYSKKTWYKELRGARAIDDEVLLLRSYIENQVITGLRKAIFGGENAAFSDSEGMNYTFGFHFGESEYLRSQDDRKLLEMLFPFPTILPLFQDDLPVSELLPFQRNSSLISRVLHWMQNVDLRTTPLPLVIMQYCLTVYIQKQRTGVDILSCAGDLLQHFLTVIFNKLDKGEAWDDDFELNTTLQESIRNSADCMLLSAPDSLVVSITKNHVDSDEEASTAGVVLSTPPQSHVNSFGINGLDMLKFTYRVPWPLELIANTEAIKKYNQGKGSATNNRKHHWLVEQKLLHFVDAFHQYVMDRGT
The following text describes a protein:
Function:
Plays a role in development of both male and female reproductive tissues.
Subcellular Localization:
Nucleus.
Domain:
The cysteine-rich domain CRC binds zinc in vitro.
Sequence:
MTGNADSGKIATEKDPRKLVFTKLEVSPVFRESPVKELPLFPPISREHSEAKDKTDEEGITSRKHKGCRCKQSKCLKLYCDCFASGVVCTDCDCVDCHNNSEKCDAREAAMVNVLGRNPNAFSEKALGSLTDNQCKAAPDTKPGLLSRGCKCKRTRCLKKYCECFQANLLCSDNCKCINCKNVSEAFQPPAFSAHNSPQVYRRRRDRELTEWNSCPAPLFSIPDNSIQNALGSPMSCSPKLPYRKKRSLMGYTSTLLPDLGDLCSLLVAASESATTTAEDQNRIFTKPDDKEAIELSSESESRNVEEEIQSRGRLIELIDVQYNGEEDSQCKTKTSVNETDIYMEQERAVLETFRDCLQKFIKSRLES
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular Localization:
Mitochondrion.
Sequence:
RICKIMIWRAPKSIWRLRPVHPQSGVLCCPGIGAVKVGHNLNGYREIHRRAAVCQRQVPQSPTWEPVEEKDLPPPTRVPPDLVDKLERLALVDFRNKEGVACLERAIRFADQLHIIDTEGVEPMDSVLEDRQLYLREDSVREGECAEQLLRASSKTVEEYFVAPPGNIPLPQREERASLLKNSEF
The following text describes a protein:
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Sequence:
MLLLELPIKCRMCGRFLRQLLAQESQHSTPVGRFLLPMLMGFRLLILVSSGPGVFGNDENEFICHLGQPGCKTICYDVFRPLSPLRFWAFQVILMAVPSAIYVAFTLYHVIGYWEVPGKENKEQETQISKGDHSKDVSGAKSLKLLWAYVAHLGVRLALEGAALGVQYNLYGFKMSSTFICREDPCIGSTTCFQSHPSEKTIFLNIMFGISGACFLFIFLELALLGLGRFWRIYKHKLSFLKKLPTSESSVRSKDTTDELSVVEAKEPF
The following text describes a protein:
Function:
May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM
The following text describes a protein:
Function:
Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2; (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein.
Sequence:
MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRGIHLNNNLNHLKFGLDYHRLSSPTQTAAKQGKMDSPTSRAGSDKIVLLVCNRACTGQQGKRFGLPFVLHLEKTIAWDLLQKEILEKMKYFLRPTVCIQVCPFSLRVVSVVGITYLLPQEEQPLCHPIVERALKSCGPGGTAHVKLVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTSARPSQKPQ
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MKCRHCSLRFQRRYELHKHERKHTGVTPYRCKQCGRYFAQSSSLNRHMNAHTAGPHVCGVCGKAFRKQSLLLVHSRAHADERPFNCCYCQKSFRKLHQLKTHQRTHTGERPYRCQECGNSFVQSAHLRRHLLTHRKKIRCLVCKKVFGAVGDLIKHRQAHAQKGMLQCPECPQQFRYPSFLRRHLRAHQRRGPLECEVCERSFGGLEQYHRHLDSHRGQTEFTCATCGGVFGSLRALKLHRNFHASRRPGQHRCRYCGKLYSSSGTLARHVRIHTGEKPFRCYGCGQRFARQEALKAHGPKEGGEKKFRCSYCPMSFARPGSLEKHHQNHREKKVFPCYKCGQCFRKSRNLRRHILTHTDVKPYRCESCGNCFSRYDHLKVHRSRCRGRRLQPQVRVVKLSLGDPAAGPGDEGPERERQEDEGAHRCAHCDKVFGVRSSLARHVAMLHTANKPFRCLRCTHTFTMLRALKSHQPKIQRHYSDLRPFRCSYCGLRFKTKSQRESHVRLHTGEKPFGCAGCGQHFMRRDYLKRHLFSGLGQKPCVCPHCAMRFCNQGALSMHVRTHSGEWPFSCSRCHKAYLRRDLLNKHQMPHYSPHRHPCPLCRRGFRAPSQLRSHRCTPTRVLCTGCGQYFGSHHLYRRHRSLGQCSRAWACLSCHRGFQSCAQLLRHQQGHAQQEGGQSHPCMHCHAAFARPGQLLQHQRAAHASKAGGFLCAECGRAFNSNSNLRVHLHVHTGARPYACQDCGKSFSQSGALKIHRRIHTGERPYVCSYCGRGFPHLAGIRAHQRTHTGEKPYRCPHCGKCFTQSGALKIHCRIHTGERPYLCAACGKGFSNRSGIRFHQKTVHGIAPDCA
The following text describes a protein:
Function:
Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable). Involved in cleaving dsRNA in the RNAi pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa. Involved in innate immunity through its role in small RNA processing; tDCR-1 acts as a deoxyribonuclease (DNase) initiating DNA fragmentation during apoptosis, upstream of nucleases cps-6, crn-2 and nuc-1.
Miscellaneous:
MISCELLANEOUS: The avoidance behavior is transgenerationally inherited, and thus progeny display this same aversion despite never been exposed to this pathogenic bacteria.
Sequence:
MVRVRADLQCFNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVEEKDTAACDSDLKDFQQIEKILLSRHRTVNNPIEDDSDRFEEFDVDSQMEPYVVEKTGATLKMSTAIALINRYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEHIDEEPDEYAPGIAAKVGSSKRKQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIEDQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDDELPFVMHDYTARLTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILGGPGGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQAKERLEALEMSEDMEKPRRLEDTVNLEDYGDDQENQEDENTPTNFPKTIDEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHIDSDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDNEIERILDGQVIEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISPLPYNLLTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRFTGMGRNYRIAKATAAKRALKYLHQIEQQRRQSPSLTTV
The following text describes a protein:
Function:
Involved in brassinosteroid (BR) signaling.
Subcellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein.
Sequence:
MDRSRGRGGDPHSSGGGSSNTAAVRATNDDAAASKLSCVKKGYMKDEYVQLFVRRPVRRAPIINRGYYARWAALRKLLLQFLKSERKTDDKNQTKKQILSLGAGFDTTYFQLLDEGIAPYLYVELDFKEVTSKKAAIINHYSQLRDKIGPEASIYIERGEVLGNHYKLLPADIRNIQTLDDVMHRAQLDPSLPTFIIAECVLIYLDPDSTCGIVRWASKTFPTAVFFLYEQIHPDDAFGEQMIKNLESRGCPLLGINATPKLQSKEKLFMDHGWKRAVAWDMLRIYNEFIDIQERRRIERLELFDEFEEWYMMQEHYCVAFAVNDAEDMFQGFGFSEDQHGDNQSQEPHPEVSKDSP
The following text describes a protein:
Function:
Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages.
Sequence:
MTAETQTLNFGPEWLRALSSGGSVISPPLSPALPKYKLADFRYGREEMLALYVKDNKVPSDLLDKEFLPILNDEPLLPLALVSFTEEEQRNFSMSVNSAAVLRLTNRGSSGGGGTVVGVPRGRSSSRGRGRGRGESGFYQRSFDEVESGFGRGAREMHRSQSWEERGDRRFEKPARKEPDGVRGSAWREIPDRRRRFDYDLRESKDERGYRRPRSGSGIAEDERDSLPEWCLDDAEDETGTFDSSGAFLSSKPSKKVQKEPIPEEQEIDFHPSVDGAEVSDSDGSQTEEAKETDPVQSQNQDDDLSRNDHTVQAAPSPDHKTSSPVRRTDMTLDTAHQKAVSPHLSCKMDAKSQSPSSPPTPSKHKEDAASASHQGTREKAGPCLPHPQSPALSQRSPARQPDPHIVPAMSSVPVPQLDTPTVPIHSSVCAAPGMEPVPPEPDEDGLEHLEQQAQQMVAYLQDGTLDDDHLLTKVLDQRVKGPSLDNQQKWYYKDPQGEIQGPFSNREMAEWYQAGYFPMTLLLRRVCDETFQPLGDIFKKWGRVPFSTPPTPRLGDLDPERLSRQQEITALYQMRHLHYQQLLFQQQYAVLAQQQKVALSSQQQQLPLPLQPLSMRIPEHTVIPPVVRALSVPESTSLWELPPAPTQPAVWEGSSVWDLPVEPTTQGTTREQLAQMDKVKAAKMEQERREAELRAKQEEEEQHRRKEAEEERKRREEEELARRKQEEALQRQKELALQKQMEEEERQRKKELQLLEERMRQEEERKRLEEERRRQEEERRKQLEERKRAEEERRRREEEKKREEDERRQLEEIQRKQEEAARWAREEEEAVRLLLEEARLKAEEEERNKREEAQRQKELQRQRQQQQEALRRLQLQQQQQQLAQMKLPSSSTWGQQVTPSAASQSALSLAEIQKLEEERERQKLQEQRHQQQELKALQQQQQQQQQKIPGWGTMSKPTGTTKSLLEIQQEEAGQMQKNHQQPGRNRPANISLPVAPVVNNHISSPTVGNSGSSVWGSLNNNLSPQWSSDSMSSIWGSTDVKGSSVGFWDDAVKEVAPRNATSKNKNNASKSAGSNSRQSKKVEQEEKLLRLFQGANKCQDDFTQWCEKTMHAINTAHSLDVPTFVSFLREVESPYEVHDYVCAYLGDTPEAKDFSKQFIERRTKQKTSQHRPQQDVAWVTCQTSQANSQPITLEAVQCAGRKKKKQKMVRADPSLLGFSVNASSERLNMGEIETAEDY
The following text describes a protein:
Function:
Involved in the assembly of the cytochrome c oxidase complex.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MWPFNSNKPQDQDGPVDFSAPVTSDGKMLDDTKPRFDLEDIQAKKAALLKELKEKEAELVRPPPPKITKPVPEGEAKVSNVVSQIGVNDFKTVTQIPCFRDAMITGFITGGSVLGVMLSMRRSTLSAANWAIGGFTIGAVAKWEMCRYNRKQSFENAALAHQVYAKRKALEEGKE
The following text describes a protein:
Function:
Facilitates the interaction and assembly of proteins within the postsynaptic density by promoting the condensation of postsynaptic proteins via liquid-liquid phase separation. Required for neuronal activity. Accumulation at the postsynaptic density results in enlargement of dendritic spines.
Subcellular Localization:
Postsynaptic density. Cytoplasm.
Sequence:
MHLRRVKTMPRHSQSLTMAPYSSVSLVEQLEDRILCHEKTTAALVEHAFRIKDDIVSSLQKMQNKGGGDRLARLFLEEHIRNITAIVKQLNRDIEVLQEQIRARDNISYGTNSALKTLEMRQLSGLGDLRGRVARCDASIARLSAEHKSTYEGLQHLNKEQQAAKLILETKIKDAEGQISQLLSRVDLSISEQSTKLKMSHRDSNHQLQLLDTKFKGTVEELSNQILSARSWLQQEQERIEKELLQKIDHLSLIVKENSGANERDVEKKLSQMSARLDKIEESQKRNAEGQRKPDEEKVHGRISKLELQMTEDMKEMKAEVNAGFSAIYESIGSLRQVLEAKMKLDRDQLQKQIQQMQKPETAM
The following text describes a protein:
Function:
Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (By similarity). Involved in JNK signaling pathway.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells.
Domain:
The N-terminal WD40 domain is necessary for the interaction with NOD2 and down-regulation of NOD2 function.
Sequence:
MMAGEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYSAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGEKADSTFCITSSGLLCEFSDRRLLDKWVELRTTVAHCISVTQEYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASITEASRLFSGGVNARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEIKDSHQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSNDLIKIIYVDGNTQALLDTELPGGDKADGSLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGIKQQGPTSPQRASGAKQHHAPVVPPSGPALSSDSDKEGEDEGTEEEELPALPILSKSTKKELASGSSPALLRSLSHWEMSRAQETMEYLDPAPVANTGPKRRGRWAQPGVELSVRSMLDLRQIETLAPSPRGPSQDSLAVSPAGPGKHGPQGPELSCVSQNERAPRLQTSQPCSCPHIIQLLSQEEGVFAQDLEPAPIEDGIVYPEPSDSPTMDTSAFQVQAPTGGSLGRMYPGSRGSEKHSPDSACSVDYSSSRLSSPEHPNEDSESTEPLSVDGISSDLEEPAEGDEDEEEEGGTGLCGLQEGGPHTPDQEQFLKQHFETLANGTAPGGPARVLERTESQSISSRFLLQVQTSPLREPSLSSSGLALTSRPDQVSQVSGEQLKGSGATPPGAPPEMEPSSGNSGPKQVAPVLLTRRHNNLDNSWASKKMAATRPLAGLQKAQSVHSLVPQDEVPSSRPLLFQEAETQGSLGSLPQAGGCSSQPHSYQNHTTSSMAKLARSISVGENPGLATEPQAPVPIRISPFNKLALPSRAHLVLDIPKPLPDRPTLTTFSPVSKGLAHNETEQSGPLVSLGKAHTTVEKHSCLGEGTTHKSRTECQAYPGPNHPCAQQLPVNNLLQGPESLQPLSPEKTRNPVESSRPGVALSQDSELALSLQQCEQLVAELQGNVRQAVELYRAVTSYKTPSAEQSHITRLLRDTFSSVRQELEVLAGAVLSSPGGSPGAVGAEQTQALLEQYSELLLRAVERRMERRL