lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome matrix.
Sequence:
MSFRPLVEGDCGGVNPLMQLGGQFTRDVAHKDEGYVQRHFERAARPEDQLINEFLGQVTAPPQSFQMDTLLQEMRDINIHGNPQQQMHSQQAEQWGQDFARGLAPALPNKMIHMQAQQQDLQHAQEFFDEPLISSQNFRSLPPLRQPLMPIAAGQQQDPFFDSAMETIITDHLPQAPQGESLDDWISDYQRSTEQKEQTAANFNEKFWERLQDEWQKLADENEHPWLSEYNDNMDAYKEYEFAEGNPMSDVENPFEKGKEYLSKGDIPSAVLCFEVAAKKQPERAEVWQLLGTSQTENEMDPQAIAALKRAYDLQPDNQQVLMALAACYTNEGLQNNAVRMLCNWLTVHPKYQHLVAAHPELQAEGTSLASSLIGPSKLRDLQQIYLEAVRQHPSEVDAEVQDALGVLYNLSGEFDKAVDCYQSALQVDPQNAKTWNRLGASLANGSRSVEAVEAYQQALQLQPGFIRVRYNVGVCCMNLKAYKEAVEHLLTALTMQAHTNAARELPNAAMAATFRGQNQMSESIWSTLKMVISLMGRSDLQSYVSDRNLAALNEAFKD
The following text describes a protein:
Function:
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Sequence:
LSSAVSIPLFRLSLCLFGRVPLIRKKSLRRTLSECGLLKDFLKKHNLNPASKYFPQWEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSIAYGTGSMTGILGYDTVQVGGISDTNQIFRPNLGSYLYLCPFDGILGWPTPAFPPRGHTRPTNLNRPVSQDLFSVYLTRLNWVPVTVEGYWQITVDSITMNGKTIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSALFNFHSFLTVVLLVICTCTFLKMQFPTILEQKTGFRGFFWKAARIGERLSPWVAVGCFTMGVSIIFF
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.
Subcellular Localization:
Nucleus.
Sequence:
MHGCGAESDPVVNAEVDSMGGVLEGGVGIGNITSPRRSAIEEVQLELRQEYCFLEEKRRELEFLEKGGDPLDFKFGNAASLSVQSTSLTDQHPDKLVTSEAKGSFAITASPHGDSVESSGRLGAPQLCEPNSADNLMLFDGENEFTEGDRSSRHPGRSNLTPSEQSFMLDRSRNAKELGDSAAFGVPRKAYKRRYRSRPNDVKGLVSDGENPKDQNSSLNIAVPSSPKGCMPVKTLASEVDGVKAAESTTYLKTDDLADSIPEASASRDLLDNQHDQNSHTGVKEMSIQEGPERLPSSLGEEAVSSAGQEGQSCTAAAGLGKQASSSQINGFSCGKSDQKSIPNDAQSSGAALGTKGLDSESSCTRTTLDRNNDREMIMNPKNLDSKGDLKEQMSVPEGTPIIESNLKEQKEVKAGDGCGLTNEVCNSGPKNHQNYFLDTSQEEFVSSEPNLLCEVKDNTTTVVEAVGPSPSETERKPSANTSDSSNLQKGNACIIGRQASVESRIPEPSQHVSPHGVSNLSPEAQASGINVKLATRGDEDSILKEAQIIEAKRKRIAELSAVTFPVENRRKSHWDYVLEEMVWLANDFAQERLWKMTAAAQMCHRVAFTARSRFQEQNSSWELKKVAHIMAKAVMGFWQSIEGKSKKLELPIFRKGHTLAIREYAMRFLKYNDSDVPQSLAEAPVTPERVSDAGIIDAPQEDHFREENLFYAVSLGAMDAYRKSIESHVLHYEKFGMHEEVETSACITVPDFGSQDYAFEEDEGETSPYDISVAIEGNKLSRFSQKKRKILIKAYNGRSYDVHTDVPFTQRVENKLGTHQSMQLGKRPASNLNVSIPTKRMRTASRQRVLSPYSATTSGCAQLPIKTDASSGDTSSFQDDQSTLHGGSHMPNSLDVESVGDFEKHLPFDSSEVSKPKKKKKSKILGAYEQRWKADSNFQKEQRDFSRKRLESHQLDSNGSNGLVGQHITKKPKMMRQSLENSFENIGAGGGFVPSPAASQMSNMSNPNKLIRMLSGRDQGRRGKTLKTSAGQPGSGSPWSLFEDQALVVLVHDMGPNWELVSDAFNSTLQFKCIYRKPKECKERHKILMDRSSGDGADSADDSGSSQPYPSTLPGIPKGSARQLFQRLQGPMEEDTLRSHFEKMILIGQKYLLRKNQGYKHDPRHLQQPHDSHTHVLSKHCTNNLNGGPIFTPLDLCDAPSSPDYLSVGCQGPHPSELSISSQCALNSVLPASGANSAVQGSSNMISGNNFPSSPLNASVRDGRYIVPRSASLPVDEQQRFQQYNQMRNMQSNMXRGNMMMHQNLQIDPSLLNGLSNNQTNQSAEKGEQATHLMQGHGLYSGTAHSPVQLAKQAVAPHSSSQPQPKIYSGQLPPSTKHLQQQMPNQDNSNQGPGSLAPSDTISSQQSVPSSVTGSSNHQGLVHQQPQVQPQPKLMNQSQATVQRVLQQNHVVNSDQSKKLQAGEPQAEQHPMCKTSQIGAITSMLQDVNDATNVADVSTLSANQWKGTEP
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system which inhibits the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Labile antitoxin with a half-life of about 1 hour in the presence of CcdB. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. The N-terminal 36 residues are not required for rejuventation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB.
Sequence:
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
The following text describes a protein:
Function:
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLKIIKLNKINQSYRIYNNTYRTLCTTNNNNSNNNGVYDIVIVGGGLVGSAMACSLGNNNNTKHLKVALIESSPIQTVNETTSNKIPDIRTISFNHQTIDLFKSIGVWDTIESTKRVNPFNQVRVWDTSGFEGIHFKDNNDIMGYIIENKVAVSSLLEKANSFENVDIISPLTVKSLENYNPNTSTTTNILPCLKLSNDKDLHAKLIIGADGGNSIIKKQLKLNSVGRNYNQRAVVCTIKLGKSDHNDTLFQRFLTTGPIALLPLADGYANIIWSTNNLHANYLLELDDNSFLEQLKNSFLSSVPTNNNSVFDALSSVFNLNPSGLSGNEIYVPPIESIVSKRASFPLRIDHTFQYTMPRICFIGDASHIVHPMAGQGVNLGMADVKALTQMIEQSVQSGYDIGDAMMLKRFEEERKPENVKMMLSIDTLFNIFTNNSIAVTALRNFGMSFLNHVPILKNLIVGVSKGNSILNNIK
The following text describes a protein:
Function:
Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs.
Miscellaneous:
MISCELLANEOUS: Asn-1791 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.
Subcellular Localization:
Nucleus.
Sequence:
MQPTLPQAAGTADMDLTAVQSINDWFFKKEQIYLLAQFWQQRATLAEKEVNTLKEQLSTGNPDSNLNSENSDTAAAAATAAAVAAVVAGATATNDIEDEQQQQLQQTASGGILESDSDKLLNSSIVAAAITLQQQNGSNLLANTNTPSPSPPLLSAEQQQQLQSSLQQSGGVGGACLNPKLFFNHAQQMMMMEAAAAAAAAALQQQQQQQSPLHSPANEVAIPTEQPAATVATGAAAAAAAAATPIATGNVKSGSTTSNANHTNSNNSHQDEEELDDEEEDEEEDEDEDDEEENASMQSNADDMELDAQQETRTEPSATTQQQHQQQDTEDLEENKDAGEASLNVSNNHNTTDSNNSCSRKNNNGGNESEQHVASSAEDDDCANNNTNTSNNNNTSNTATSNTNNNNNNNSSSGNSEKRKKKNNNNNNGQPAVLLAAKDKEIKALLDELQRLRAQEQTHLVQIQRLEEHLEVKRQHIIRLEARLDKQQINEALAEATALSAAASTNNNNNSQSSDNNKKLNTAAERPMDASSNADLPESTKAPVPAEDDEEDEDQAMLVDSEEAEDKPEDSHHDDDEDEDEDREAVNATTTDSNELKIKKEQHSPLDLNVLSPNSAIAAAAAAAAAAACANDPNKFQALLIERTKALAAEALKNGASDALSEDAHHQQQQHHQQQHQHQQQHHQQQHLHQQHHHHLQQQPNSGSNSNPASNDHHHGHHLHGHGLLHPSSAHHLHHQTTESNSNSSTPTAAGNNNGSNNSSSNTNANSTAQLAASLASTLNGTKSLMQEDSNGLAAVAMAAHAQHAAALGPGFLPGLPAFQFAAAQVAAGGDGRGHYRFADSELQLPPGASMAGRLGESLIPKGDPMEAKLQEMLRYNMDKYANQALDTLHISRRVRELLSVHNIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSLIPKKDSGLPQYAGRGAGGAGGDDSMSEDRIAHILSEASSLMKQSSVAQHREQERRSHGGEDSHSNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQAAAQQREREREQREREQQQRLRHDDQDKMARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHVFEREIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAPPAPPSGPGTGAGAPPTAAPPTGGASSNSAAPSPLSNSILPPALSSQGEEFAATASPLQRMASITNSLITQPPVTPHHSTPQRPTKAVLPPITQQQFDMFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQVPHGPAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAGAAAAAAAVGASGGDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDLELEGGGHNLSDNESLEGQEPEDKTTDYEKVLHKSALAAAAAYMSNAVRSSRRKPAAPQWVNPAGAVTNPSAVVAAVAAAAAAAADNERIINGVCVMQASEYGRDDTDSNKPTDGGNDSDHEHAQLEIDQRFMEPEVHIKQEEDDDEEQSGSVNLDNEDNATSEQKLKVINEEKLRMVRVRRLSSTGGGSSEEMPAPLAPPPPPPAASSSIVSGESTTSSSSSSNTSSSTPAVTTAAATAAAGWNY
The following text describes a protein:
Function:
Cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase II transcriptional elongation, and as part of the CTDK-I complex, pre-mRNA 3'-end processing and SET2 mediated H3K36 methylation. Together with CTK3, required for CTK1 CTD kinase activation. Required for DNA damage induced transcription. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus.
Miscellaneous:
MISCELLANEOUS: Present with 1590 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MPSTFESQLFFSRPFLSKRQIQRAQKNTISDYRNYNQKKLAVFKFLSDLCVQLKFPRKTLETAVYFYQRYHLFNRFETEVCYTVATSCLTLGCKEVETIKKTNDICTLSLRLRNVVKINTDILENFKKRVFQIELRILESCSFDYRVNNYVHIDEYVIKIGRELSFDYKLCNLAWVIAYDALKLETILVIPQHSIALAILKIAYELLDNKNWSSKRYSLFETDEKSVNEAYFDIVNFYINSFDMCDLQRHLPADLLPIGVERFMELKKNAGPESGLPQIPDHLLNADPYITITRDNNVQERRYVLSLELINGESSINSSTRHA
The following text describes a protein:
Function:
Required for transport of secretory proteins from the Golgi complex (By similarity). Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Sequence:
MTDTMSAHMDRHNKLDYDGSEDEKKTKLCSLKKKAINASNKFKHSFTKRTRRNSRVMSVSIVDDIDLEELQAVDAFRQALILDELLPSKHDDHHMMLRFLRARKFDLEKAKQMWTDMIHWRKEFGVDTIMEDFDFKEIDEVLKYYPQGYHGVDKDGRPVYIERLGQVDATKLMQVTTIDRYVKYHVREFEKTFNIKLPACSIAAKKHIDQSTTILDVQGVGLKSFSKAARDLLQRIQKIDSDNYPETLNRMFIINAGSGFRLLWSTVKSFLDPKTTAKIHVLGNKYQSKLLEIIDSNELPEFLGGNCTCADKGGCMRSDKGPWNDPDIFKMVQNGEGKCPRKTLSNIEEKTISVDENTTMKSDSFAKNKFDAENTKFIPMIDKTVNASTWPTNLHKSNYPEPEDLYSAVKPSQRRGGEGYLFGGVMSLVMGLMTVVRLTKNMPRKLTEAAIYGGEVDKAETTMVSNQEYMSMVKRMAELEEKCRSLDNQPAAFSPEKEQILTAALSRVDELELQLAQTKKTLEETMATQHVIMAYIDKKKKKKKFFGF
The following text describes a protein:
Function:
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
Subcellular Localization:
Cytoplasm.
Domain:
The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
Sequence:
MADNDSTSSPQFVLPAIHDHPDAWGPSPTALPTQFKDIPYAPFSKSDKIGRIVDWNAESGQLSVGANAHQRGFRANRGSTREAYGAGQGGTFAYFHDEDEASFNLVGGGTGSNRGTGGLMGLNRGARGRGSNLRGTAGRGRGAGGRLERGSGARGGAGRRGGQWGRGGGTWKGDWGDRNSRIRESTVVIGQDWQVLEEIEFSRLAKLRLEVDVDAAEDVSTHGFLYEYDRTYDRINTKNPQPLQILDRSRYHPTASEDPIIQELAAQNKAQVFTTDSVLSLLMCATRSVYPWDIVIIKEGGKLFLDKREGGPFDFLSVNENAADPPAESDKPDSPNTPSALSLEATFINQNFGLQVVKEDPKTAYQFEQPNPFYGPDETEPCASAGLRYRSFDLSLSEEEEMTLIIRTEVDAVLRGPNATNVKEQGGNDEDSFITIRTLNEFDSNSQGSGGAPNWRAKLDTQRGAVVATEMKNNSCKLAKWAVQSILAGADQMKMGYISRANPRDASRHVILGQQWLKPKDFAAQINVNLSNGWGIVRTAIDLAFKAEDGKYLLMKDPNKPVVRLYKVPENAFDLQEDEEDGEEADEDDELDLGT
The following text describes a protein:
Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLVISVVGSSNIDIVLKVDHFTKPGETQKAIEMNVFPGGKGANQAVTVAKIGEKGCRFVTCIGNDDYSDLLIENYEKLGITGYIRVSLPTGRAFIEVDKTGQNRIIIFPGANAELKKELIDWNTLSESDILLLQNEIPFETTLECAKRFNGIVIFDPAPAQGINEEIFQYLDYLTPNEKEIEALSKDFFGEFLTVEKAAEKFLELGVKNVIVKLGDKGVLLVNKNEKKHFPTFKVKAVDTTAAGDVFNGAFAVALSEGKNPEEAVIFGTAAAAISVTRLGAQSSIPAREEVEAFLKNL
The following text describes a protein:
Function:
Catalyzes the hydroxylation of uric acid to 5-hydroxyisourate.
Sequence:
MKALVIGGGIGGLSAAVGLKNAGIHCEVFEAVKEIKPVGAAISIWPNGVKCMKHLGMGDIIESYGGPMHFLAYKDYLRGEDLTQFSLAPLVERTGGRPCPVPALNLQREMLDFWGRDAVQFGKRVTRCEEHADGVRVWFTDGSMAEGDFLIAADGSHSALRPYVLGYTPERRYAGYVNWNGLVEIDEAIAPGNQWTTFVGEGKRVSLMPVSDGRFYFFFDVPLPAGLAEDRSTLRADLSRYFSGWAPQVQKLIAALDPQTTNRIEIHDIEPFERLVRGKVALLGDAGHSTTPDIGQGGCAALEDAVVLGDLFRESRDIAGVLRQYEAQRCDRVRDLVLKARKRCDVTHGKDMALTQAWYQELETETGERIINGLCETIQGGPLG
The following text describes a protein:
Function:
Vital for larval development. During salivary tube elongation, possibly modulates cellular adhesion between the apical surface and apical extracellular matrix, and acts as an apical membrane determinant that functions in apical membrane expansion independently of crb and Cad99C.
Subcellular Localization:
Apical cell membrane; Single-pass type I membrane protein.
Domain:
The extracellular domain is sufficent for conferring apical characteristics on the salivary gland membrane.
Sequence:
MQTCRRRKASGGQSTIKWSRMCLATLCGLLLLGIQIERAASAPAGEDAAATTMPPLDTTTDAPDAVAATTTPATTAAEQSSSISSITTEAADGSTTSTTTTTEAANKSNATETDFTTNVPVASSLPEETSVRSTSIEPITSTEPTTTPRQETEGPDQHMVFSNTEPDQSHIQHIPLRDEHAESSGADDATTEMQRQREQDQQQNELNQISNEQDDVVKDLNNFRHPATLITASNSNSEENVEIESDKQVETTTTAVPAAATSTSTEATGTPPTGTPATSTSTVPNEREEDPYHVHILSENHDRLAEHEDYQMLSTSTEESSTTSTTSTTNSTTESGIVAGIVVSQENKATAEPSTATESTSISTSTTTAATAATSTTSRARAMHMNDPEDEAATTIMPDSESVPVINIVEGQHMLQQEDQKDEEEEGVVKESESSSTTEASTTTTEPSPFVAFAGEGRSAGGGNDIELFLHHNGSTHEQLMDLSDVSMDGDQNEGSSKTESSTTSTTTTTAQPETEMPKIVEITASGDTMQRECLANNKSYKHGELMERDCDERCTCNRGDWMCEPRCRGLSYPRGSQRSMANPNCLEKMVEEDECCRVMECSEPQLEPTVVATEGAAPSTNGTGESAVTLPTTDDEATPKPRTDCHYNSGVYKFRERLEIGCEQICHCAEGGVMDCRPRCPERNHTRLDKCVYVKDPKDVCCQLELCDVTLDDHEQQPTPLQSNNNEDPEEIDPFRFQEQARDAGGAKPTCTFKGAEYDVGQQFRDGCDQLCICNEQGIHCAKLECPSNFGLDVQDPHCIRWEPVPADFKPSPPNCCPESMRCVDNGTCSYQGVQIENWSPVPANLTGCDQHCYCENGRVECRAACPPVPALPPADLPCHPALARLLPIPDDECCKHWMCAPQIPKIGGAGQDEETEATSTHSSIPANETTTTTATANKSTSIPSKVPQIKKDEEKRPPASGAFYPTLDGKPPKSIGGLGIFEKPEKPEKAHKKVQHQQQQHQQQEQQEQQQHQNDVIFDGDRTEEQEEPLPPNGGFVPFQFGQQHPHQPHLGPYGFYNPVKPVYEDYNPYEPYDINPNGTPQGKPPPVPTSQSDLFNILGAEQPGHPVHPGHGGPPRIHPGQTQKDNHNLGPQVRIEQILQHLQQTVPGGPPPPPPHQQHQSLTPQLHPQQQQISQQHPGHYVPIVHSGVPPPPPGHGIAIVDGQTVAYESYPVIPGLGVPQHHPQQHQTTPQQHLQQTILPSSSTTSGLSTQASEHSLHQNQGKLAKQQQSGANNLQPDIEVHTLEAIDPRSIRIVFTVPQVYVNLHGRVELRYSNGPSNDTSTWEQQIFAPPEDLIATSQMEFDLPSLEPNSLYKVKITLILRDLNSQPTSSIYTVKTPPERTITPPPPFPDYRPDFQDIFKNVEDPELTVSETNASWLQLTWKKLGDDQMEYVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGHGAELRAGHMIKVRTAQKVDVYGFDVTVNVTKVKTQSVEISWNGVPYPEDKFVHIYRAIYQSDAGKEDSSVFKVAKRDSTTGTLIMDLKPGTKYRLWLEMYLTNGNTKKSNVVNFITKPGGPATPGKTGKLLTAGTDQPVGDYYGPLVVVSVIAALAIMSTLALLLIITRRRVHQTASITPPRKSDAAYDNPSYKVEIQQETMNL
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSQLSTSLSKIFGIIFVRAQDGTRLYSKYYPQLFPKNLLRVPEGVLTNIDVQKQFEHNVWEKGKRVGARLTKGSETEIFQYCQFNIVMKAFNEVHLFVLGDFEENEIILSQVINGIYESLNHITKDHINKKTLLENFDQVIIIIDEICDQGIIITIDPSVIIARSTMRDTEAVSLDKQETSGSTGGAFSSVFASAKRTFAQQFMGSG
The following text describes a protein:
Function:
RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.
Subcellular Localization:
Cytoplasm, P-body. Cytoplasm, Stress granule.
Sequence:
MNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPRPDRLVNRLKNITLDDASAPRLMVLRQPRGPDNSMGFGAERKIRQAGVID
The following text describes a protein:
Function:
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
Sequence:
MSSRVGDLSPQQQEALARFRENLQDLLPILPNADDYFLLRWLRARNFDLQKSEDMLRRHMEFRKQQDLDNIVTWQPPEVIQLYDSGGLCGYDYEGCPVYFNIIGSLDPKGLLLSASKQDMIRKRIKVCELLLHECELQTQKLGRKIEMALMVFDMEGLSLKHLWKPAVEVYQQFFSILEANYPETLKNLIVIRAPKLFPVAFNLVKSFMSEETRRKIVILGDNWKQELTKFISPDQLPVEFGGTMTDPDGNPKCLTKINYGGEVPKSYYLCEQVRLQYEHTRSVGRGSSLQVENEILFPGCVLRWQFASDGGDIGFGVFLKTKMGEQQSAREMTEVLPSQRYNAHMVPEDGSLTCLQAGVYVLRFDNTYSRMHAKKLSYTVEVLLPDKASEETLQSLKAMRPSPTQ
The following text describes a protein:
Function:
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Begomovirus genome is shuttled out of nucleus by Nuclear shuttle protein (NSP) and the movement protein transports the DNA-NSP complex to cell plasmodesmata and facilitates further movement across the cell wall. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.
Subcellular Localization:
Host cell membrane; Single-pass membrane protein. Note=The hydrophobic region is responsible for the localization of the protein to the cell periphery.
Sequence:
MALTTERVKLFFEWFLFFGAIFIAITILYILLVLLFEVPRYIKELVRCLVEYLTRRRVWMQRTQLTEATGDVEIGRGIVEDRRDQEPAVIPHVSQVIPSQPNRRDDQGRRGNAGPMF
The following text describes a protein:
Function:
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
Sequence:
MSDTASWQPSAPIANLLKRAAIMAEIRRFFADRGVLEVETPTMSQATVTDIHLVPFETRFVGPGAADGLTLYMMTSPEYHMKRLLAAGSGPIYQLGRSFRNEEAGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQILDCNSAETLSYQQAFLRHLNIDPLSAEKAQLREVAAKLDLSNIADTEEDRDTLLQLLFTVGVEPYIGRDKPAFIYHFPASQASLAEISTEDHRVAERFEVYFKGIELANGFRELTDGDEQLQRFEQDNRNRAKRGLPQNPIDMNLIAALKQGLPDCSGVALGVDRLVMLALNAERLSDVIAFPVNIA
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MEKKVLIVGISQKQKDFDYSMEELANLAAANNMEVVGEIRQNIDRENRATYVGKGKVDEIKGLAEMQDARLIIFNDELSPSQIRNLEEALELDVMDRTGLILAIFANRAKTKEAQLQVQIAKLQYELPRIFGQGEDMDQQSGKGGLSNRGSGEKKIETDRRTIKHQIRHLQKELDMLVDDREVRRRKRKKNEIPVVSLVGYTNAGKSTTMNGLVRAYSETADKQVFEKDMLFATLETSVREIVLPDNKQFLLTDTVGFVSKLPHQLVKAFRSTLEEARDADLLIHVVDYSDPHYKTMMKTTEETLKVVGVEDVPVIYAYNKADLLEDEMYPKQTGNTIIFSAREEESLEFLTEVIRKELFASYEKATFLIPFEAGQVVAYLNEHADILETEYLENGTQIVAEVSPADLQKLAEYQVAE
The following text describes a protein:
Function:
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular Localization:
Nucleus.
Sequence:
MLDGKNFLNTDTVIILEGDASVENGENPKRHSINIIMTNAMELKLIVTAKRKRPTHSSAVFNAVISAMLRGRESLIRLVGKRQRNVSLPAREELECGDVSLEIKGGLSLACCDWVECPVCGKQIRGNELLVNCHLDTCLQSGKKKKNNVQHTLFHFNLSKKIEYEESGNCVLEIQQSPPLETGVDCNTAAGSPKPEVSSTLECFEEPDVANSVLPAERYLSPLMEKGVVDVQGYVSESTLEAARLKLDLREIQNRTIGSLSEEKVLAVKWSRLMDAADKGQDRGCQYQQNFLYMLQVVLERDLHLFTPDEIELLEAFRSISSDGQRLGSTKGGTLLSFRRDVNSSELLEHLTVRELKDLAVNSKIMIKSAMLSLKKIQLITAIRDALISLHFNLTALIREATGPCIRIAETVEVLLWHLQRLFFLNGEQEFHVFLLVDIGRIKYPGYRCARTMPVFSSREDFLAYEQHPFLARFSAAWVYATTVAASFLEKERRYAEAVNLFKQLLSMQYCPGRRGYWTLRQSIDLEHLQRLEESLLVAENGLNDFNVRGGDRIALQRRVLRLDIWPSATTLFLKVTIMGRPLNNANGMKSRFYGYDGQQCSVEDLALQYYAGEDGGGWKGTAPLDLCTDSFYPVRSSLIESRLQAIRDGGARQLVAETWAEHYGTSCSGVNWEKYSLEDLQTITVCIGGPGLSVICKLLAEDHSNWTAGMPDLLLWKEKEAKLAEVKGPGDRLSEQQVACFLILSDANVPVELCKDEPNTGGFECRALGPKLYLLANRYLPAKWEEKLVLDVFQTHFRDCTIGLVHGFLSIQSEARLLNLLFKPYAMVELGNSSWKHSGRVNWENEDLHTITGLSVIHMLLAENQGGQNWSKPRVREIACPSNRHSHNWWHLELCHLEGGPAENVLRIFDTRIWGDHERAERDTFAVSLNALEFLLCLQVNRFGDHITKLFVDKRPNNYSHIESTVRNVVKVTSL
The following text describes a protein:
Function:
Antagonizes host cell apoptosis by interacting with host ferritin heavy chain. The ORF4 protein physically binds host FHC, resulting in the reduction of FHC protein levels in host cells. Reduction of FHC concentration further inhibits the accumulation of reactive oxygen in host cells, leading to reduced apoptosis.
Subcellular Localization:
Host cytoplasm.
Sequence:
MTCTLVFQSRFCIFPLTFKSSASPRKFLTNVTGCCSATVTRLPLSNKVLTAVDRSLRCP
The following text describes a protein:
Function:
Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
Subcellular Localization:
Cytoplasmic vesicle, phagosome membrane. Late endosome membrane. Lysosome membrane.
Sequence:
MEPRRATPGAHVWGPQVTAGSGTTAELVYHLAGALGTELQELARRFGPEAAAGLVPLVVRALELLEKAAVGPTPDSLQVAAQQAEVELRRLREENERLRRELRSGPQEDRALLRQLKEVTDRQRDELRAHNRDLQQRSQETEALQEQLQRLLLVNAELRQKLAAVQTQLRAARDRESQLEPRREGAVELAQGPARDQAEPATAGAGAPGTPGDPADAPQQPGRPSQVGQCNFSREELEQILQERNELKANVFLLKEELAYFQRELLADHRVPGLLLEAMKVAVKKQRKKIKAKMLGTPEEAESSDDEDGSWLLLSSDKGDHPPPPESRIQSFFGLWYRGDTEAPEAETSSSRAPSELGGKEEAPQQPHLEPVDSPTAPNS