lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
Subcellular Localization:
Secreted.
Sequence:
MLVYRILSLSLGLLLVVLSAVEPQPCPAPCSCSGTTVDCHGQGLRNVPRNIPRNTERLDLNANNLTRITKSDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNNLQVLPELLFLGTMKLYRLDLSENQIQGIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNHLYCDCNVAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKKEFVCSGQQSSPSCSVLQCPDSCTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNAIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFALQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFASLRAIQTLHLAQNPFICDCHLKWLADYLHDNPIETSGARCTSPRRLANKRIGQIKSKKFRCSGTEDYRSKLGGDCFADLACPEKCRCEGTTVDCSNQKLTKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGAFEGAAGVNELILTSNRLENVHFRMLKGLSGLRTLMLRSNRISCVGNNSFTGLSSVRLLSLYDNQITTMAPGSFDTLHSLSTLNLLANPFNCNCHLAWLGEWLRKKRIVTGNPRCQNPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLARCPAECTCLDTVVRCSNKGLKALPKALPKEVTELYLDGNQFTQVPRELSNFKHLTLIDLSNNQISTLSNQSFSNMTELLTLILSYNRLRCIPIKAFDGLKTLRLLSLHGNDIAIIPEGAFHDLSSLSHLALGANPLYCDCNMQWLSEWVKSGYKEPGIARCAGPGEMTDKLLLTTPSKKFTCQAIPGPCGFLVPGPVDVTILAKCNPCLSNPCRNDGTCNNDPVDFYRCTCPYGFKGQDCDVPIHACISNPCGNGGTCHLKEGEKGGFWCKCADGFEGETCEINIDDCEDNDCENNSTCIDGINNYTCLCPPEYTAANLNEVEKGELCEEKLDFCAPELNLCQHDSKCILTPKGYKCECMPGYVGDQCDIDFDDCQENKCKNGAHCIDAVNGYTCVCPEGYSGLFCEFSPPMVLPRTSPCDNYECRNGAQCFVKDTDPECQCLQGYHGEKCEKLISVNFVDRESFLQIPSSLIDSQANISLQIATDEDNGILMYKGDNDHIAVELYRGRLRVSYDTGSYPPSAIYSVETINDGNFHVVELVALDQTLSLSIDGGSPKSISTLSPQSTLSLDSPLYVGGMPVKTNVAALRQGPGQNGTSFHGCIRNLYINNELQDFSKFQLQAGILPGCEPCQKKVCVHGTCHATGQSSFTCECEGGWTGVLCDQQTNDPCHGNKCIHGTCVSINAFSYSCKCQPGYGGVLCDEEEDVFNPCQSIKCKHGKCRLSGLGKPYCECNSGYTGDSCDRASSGRTQNPTQVRQRSFVEGNGSEITIRNSRGMPRARPPKRSHG
The following text describes a protein:
Function:
Exhibits cGTPase activity; binds and hydrolyzes specifically GTP. May participate in ribosome assembly and stability and thus regulates protein synthesis in chloroplasts. The GTPase activity requires MgCl(2)and the presence of either KCl or (NH(4))(2)SO(4). Involved in the post-transcriptional regulation of the methylerythritol phosphate (MEP) pathway. Involved in chlorophyll-a fluorescence regulation; May mediate the production or accumulation of nitric oxide (NO) which is a messenger molecule involved in hormonal signaling and defense responses in plant. Acts as an antisenescence agent. Plays a crucial role in both extracellular calmodulin (ExtCaM)-triggered and salicylic acid (SA)-mediated H(2)O(2)-dependent stomatal closure.
Subcellular Localization:
Mitochondrion. Plastid, chloroplast. Note=Was initially thought to be mitochondrial. In fact seems to be chloroplastic.
Sequence:
MALRTLSTFPSLPRRHTTTRREPNLTVIYRNPTTSIVCKSIANSEPPVSLSERDGFAAAAPTPGERFLENQRAHEAQKVVKKEIKKEKKKKKEEIIARKVVDTSVSCCYGCGAPLQTSDVDSPGFVDLVTYELKKKHHQLRTMICGRCQLLSHGHMITAVGGNGGYPGGKQFVSADELREKLSHLRHEKALIVKLVDIVDFNGSFLARVRDLVGANPIILVITKIDLLPKGTDMNCIGDWVVEVTMRKKLNVLSVHLTSSKSLDGVSGVASEIQKEKKGRDVYILGAANVGKSAFINALLKTMAERDPVAAAAQKYKPIQSAVPGTTLGPIQINAFVGGEKLYDTPGVHLHHRQAAVVHSDDLPALAPQNRLRGQSFDISTLPTQSSSSPKGESLNGYTFFWGGLVRIDILKALPETCFTFYGPKALEIHAVPTKTATAFYEKELGVLLTPPSGKNQMQEWKGLQSHRLLQIEINDAKRPASDVAISGLGWISIEPIRKTRGTEPRDLNEAEHEIHICVSVPKPVEVFLRPTLPIGTSGTEWYQYRELTDKEEEVRPKWYF
The following text describes a protein:
Function:
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
Miscellaneous:
MISCELLANEOUS: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
Subcellular Localization:
Cytoplasm.
Sequence:
MVPELMFDEPRPGRPPRHLADLDAAGRASAVAELGLPAFRAKQLAHQYYGRLIADPRQMTDLPAAVRDRIAGAMFPNLLTASADITCDAGQTRKTLWRAVDGTMFESVLMRYPRRNTVCISSQAGCGMACPFCATGQGGLTRNLSTAEILEQVRAGAAALRDDFGDRLSNVVFMGMGEPLANYARVLAAVQRITARPPSGFGISARAVTVSTVGLAPAIRNLADARLGVTLALSLHAPDDGLRDTLVPVNNRWRISEALDAARYYANVTGRRVSIEYALIRDVNDQPWRADLLGKRLHRVLGPLAHVNLIPLNPTPGSDWDASPKPVEREFVKRVRAKGVSCTVRDTRGREISAACGQLAAVGG
The following text describes a protein:
Function:
Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSGRDAGGRSIATNRLRKEQREVGLALANGQARRRCRSRPLRPGSLIPEGAGFPKMAADVSVTHRPPLSPKPEAEAEAGGVGERRTLDEKLPPLDPEEVRSRLERTERQFRNRRKILIRGLPGDVTNQEVHDLLSDYELKYCFVDKYKGTAFVTLLNGEQAESAIRTFHQSHLRDKELSVQLQPTDALLCIANLPPSYTQQQFEELVRPFGNLERCFLVYSERSGHSKGYGFVEYMKKDSAARAKSDLLGKPLGPRTLYVHWTDASQLTPALLHSRCLCVDHLPQGYSDVDELRQALSSVHPPTFCQLAYGQDGQLKGFAVLEYETSQMAEEAQQQADGLVLAGNSVRVSFCAPGPPGRSMLAALIAAQATALNRGKGLLPEPNILQILSSLGPPASLQLLLNPLLHGPGGGNKQGLLGAPPAMPLLNSPALSTALLQLALQTQGQVQQKPGILGDSPLGSFQSGTQPSNTLLGELPAGGVLPSDIPPVRGKPPSLLPPLLGTAGGDREALALGASATQLTPPPASLRGSVLSGLQKLSENGPPPTSGVSLLGEPPKDFRIPLNPYLNLHSLLPTGSGSKAFNLKSSMLGGTSSTRLSTDSGLSSDGYGFDYPPDLGPRRMFSHPRESVGPILGPLGHSRHKMSPPPSGFGERGSGSGGLPHFYSGSPTSYFTSGLQAGLKQSHLSKVVGTSPMGSGEGLLGLGPGPDSHGSLMKVNGLGQVVSGEDWGRGPPFTYCFVLCIHRLLWVARNGASPICFLPQSLALKGGMWGSIPKAWGAIMQIPT
The following text describes a protein:
Function:
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MVGLSIVLEMTNNNNNNNNNNNNNNNKNPLSEGVLISPKVVNKANIIVTTAVTTDTTNLRRCYQDSGFLEHCFLCRRKLLPAKDIYMYKGDRAFCSVECRSKQMIMDEEESLRREYCSLMDVKKKKFDSPATAPSRYRRDPRNQAGGFAY
The following text describes a protein:
Function:
The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAADISWDEIKKENVDLEKIPVDEVFQQLKCSREGLSSEEGRNRLQIFGANKLEEKVENKFLKFLGFMWNPLSWVMEAAAIMAIVLANGGGRPPDWQDFVGITCLLIINSTISFIEENNAGNAAAALMANLAPKTKVLRDGRWGEQEAAILVPGDLISIKLGDIVPADARLLEGDPLKIDQSALTGESLPATKHQGDEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNNVGHFQKVLTAIGNFCICSIGIGMLIEIIIMYPIQHRKYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTVDKNLIEVFSKDVDKDYVILLSARASRVENQDAIDTSIVNMLGDPKEARAGITEVHFLPFNPVEKRTAITYIDTNGEWHRCSKGAPEQIIELCDLKGETKRRAHEIIDKFAERGLRSLGVARQRVPEKDKESAGTPWEFVGLLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIGKETGRRLGMGTNMYPSSSLLENKDDTTGGVPVDELIEKADGFAGVFPEHKYEIVRKLQERKHIVGMTGDGVNDAPALKKADIGIAVDDATDAARSASDIVLTEPGLSVIVSAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLVALIWEFDFSPFMVLIIAILNDGTIMTISKDRVKPSPIPDSWKLKEIFATGVVLGTYMALVTVVFFWLAHDTTFFSDKFGVRSLQGKDEELIAVLYLQVSIISQALIFVTRSRSWSFVERPGLLLLIAFFVAQLIATLIATYAHWEFARIKGCGWGWCGVIWIYSIVTYIPLDILKFITRYTLSGKAWNNMIENRTAFTTKKDYGRGEREAQWALAQRTLHGLKPPESMFEDTATYTELSEIAEQAKKRAEVARLREVHTLKGHVESVVKLKGLDIDNLNQHYTV
The following text describes a protein:
Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEEIPFQKVKTRRKKCHCLSAPHLDAIACEDEFDCKELESLFQNYNLKLEQTSTLKALAVLIIMTGTLALLELMSSRSVTISKGSQPVHCIIFLSLFIVTNVKYLQVTQLQQIVKLTLLFSFTFSFLCCPFSLGAYGLEPTVSSEQGLWQLMLVTFVAYALLPVRTLLAIVFGFMVSVSHIIVTATSISPKKKKLWRTLVVNAILFVSVNLSGVFVRILTERAQRNAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITFKPRVLDLNVSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSFLKKHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNIIHNTPGTRVNRYIGRLIEARQTDSQMSDLNFITLKYKHVEREQKYHQLHDEYFTSAVVLSLILATLFGLVYLLIFPQSTIVLILLVVCLCFLVACIMYLHVTRVQCFPGCLTIRIRTILCIFIVILIYSVAQGCVVGCMPWIWRLNNSSSIMIITPKENKTMNERPCDTAHYTFLTCVVGTLSLAIFLRISSFPKMILLLFVTVLYIVVLEISGYRKTLRGDYSYLRGYEPIVAILLFSCSLALHSRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNEFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGKGEMLTYFLEGKVDGTNSQTRSLNLERKMYPYGRTNIQTKLGTSFPAESSISNIPAKAGQGALQPTTSHANQTLHYLPSVPAIKEA
The following text describes a protein:
Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Sequence:
MAGRRVVVFPSAAELGPVLASLVASRAEKAISSRGRFTLGLSGGSLVNILSKELPALPELDCSKWVVGFCDERLVSFDDPESTYGLYKSQLFSKVNIPDNAVLTIDSSLSVQDCAEDYTRKLKKAFPDDEFPVFDLLLLGMGPDGHTCSLFPDHPLLEENKKIVAPISDSPKPPPQRVTMTFPVVNAARCVSFVSTGGSKAQVLKEVLEGREGSVYPAARVAPTKGELFWLLDDPAAASLSIHVERPGSGETL
The following text describes a protein:
Function:
Transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MAQEEIMRRGPWTEEEDLQLVFYVKLFGDRRWDFLAKVSGLKRTGKSCRLRWVNYLNPDLKRGKMTPQEERVVLELHSKWGNRWSRIARKIPGRTDNEIKNYWRTHMRKKAQEQRKKSSISPSSSFSNSSSSSSISHEEXNFYDTGGLELLKAEGEMKSSDQEQGGESMKIYSMDEIWKDIELLEENEETTNKPIMGSISPLWDYSLDSLWKDFDWSSFR
The following text describes a protein:
Function:
Probable transcription factor that is required for normal development of the outer retina.
Subcellular Localization:
Nucleus.
Sequence:
MEDHTVHQTEHMTTIEAHAVSQQVGQVHVATYTEHGMLSADEDSPSSPDDDAYDDSDILNSTGTDEVTAHLAAAGPVGMAAAAAVATGKKRKRPHIFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFRVFGAAPLENVVRKYKSMILEDLENALAEHAPPGGGELSSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQVTTQVATTATHSIAHLVPSQTVVQTISNPDGTVSLIQVGTGATVATLADASELPGTVTVAQVNYSTVTDGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQTGATVTMALNRYSLEGALKFGEAAAHAVATLAEATLQGGGQIVLAGETAAAVGALTGVPDGSGLVQIPVSMYQTVVTSLAQGNRPVQVAMAPVTTRIDNTMTLDGQAVEVVTLEQ
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MTTQPAVGDPLSDLWEHLMSPNRTHLSCFYPSKITMSGIWTGDNPLDFSLPLILFQMLLITSTTRAATLLLAPLGLPRYISEILGGFVLGPSVLGRLPHYTDIVFPPRSIFILDSMALFGLVYYSFTIGVEIEVPTITRAGFRSFWFAGASALLPFLIGATTGYVALGTDDSRKNADFVDRLSFPIFLGSTFASTAFSVLARNIAELKLAGTDVGQITLSTALINDTIAWTGLTVATALLYAEDSGLLPSVWTLLSGLVIFGASVLLVRPALVRLAQRATMEGEVIGEERECAVLVGVMVAALVADAGGTHVIFGAFVFGLAVPNGPVGVELVEKVEDYVVGTLLPLFFAMSGLRTDTSKVTSMEAAVLLMVATIAASVLKVVACIGVAAGFGMPLHDGTSIGLLLNTKGVIELVILNIARNKKIMSDQSFTVLVFMSALITALVSPLLTMVVKPARRLVFYKRRTVAWPQPDAELRVLACVHVPRDAPAAITLVDVLWPSRRSPIAVHALHLIEFAGRASALLLINAAAPAASSSEFSDQGRSHVEMQFKHIAHAFMAYAENHAPGGVLARTMAAVSPYASMHEDITAAAEDQHSALIVLPFHKHRSVDGGMEVSHPAIQSLNASVQSCSPCTVAILVDRSLGSGGTLPGGAGGYRVAALFFGGRDDREVVALATRMARNPAVDLTVMRFVQKGRAGSMTSSEFDALKERKADDWCMREFLERANAGGGGVDYCERGVFNASEMVAEIRNVEAAGKDLFLVSRTPGATGLTAGMSDWSECPELGPIGDLLVSKDFQTKASVLVVQSYGRAAASSASASSEFAVGEAVLPAPEAIMPATSMGHPPRRPRQHSHSDIML
The following text describes a protein:
Function:
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted.
Sequence:
REVLTPLWCLCCCLCPCPEDFTSSSTFYTQLLTLVLLFFLCLGALNQTSWGKKYPACNGAKQSPINIDEDLTQVNVNLKDLKFQDWEKETSKDTLIFNTGKTVEIKLINEYFVTGGGLEGVFKASKIMFHWGKCNISQDGSEHSIDGQKYPLEMQIYCYDPNRFADIDKAVEGNGRLRVLSILFEVGLEDNGDYNTIIDGVARVSRFGKKSELEPFILSNLLPNSTNKYYTYNGSLSTPPCSESVEWIIFKDTVNISENQLSVFCDVLTMQQSDYVMMMDYLQNNFRDQQLKFSGQVFSSYTGQEEIHEAVCSLEPENVQADPKNYTSLLVTWERPRIVYDTMIERFAVFYQQLEGEDQKKHEFLTDGYQDLGAILNNLLPNTSYVLQIVAICANGLYGKYSDQVIVDMPLDDPECSLYALFSKEEDELEETREGVGEEAAVISSTDSMTNQIRKMEFQFTTSSYDQERMGTKFNEAGTHKYVTREDDAHGKDDQSKTFFHPTSESIAEIPKKEQDDSVESQSATTSSSTKGNEEEYAHAFSDNEARAPTTDGIEDDIEVSAFKPDPDTDDSWSSTHTTSPSWLVTVETAQESIVSSGSPEKMHDDLSQDYIKILSEDVTPPSAEDSAEKVLEANGNLWYHNGTDATAVPLDTKQLFHVSSPNPTTIPYPGGPLVSQESSGVDIELPHTSTFAFSPTELLPYSASSNSEEHGSASSANEVLSQTTQPVYNGEIPLQPSYSSEVLPLVTPLLSDAQMLNTFPAASSSDVTLHATPVFPSVGVSFESTLSSYDDVPLLPFSSASSSSKVFHHLYMVSQTFPRATPAIENDKVSMHAPLTLPEAGTLMQTRLTQFSDVTSHQTVGAASETLIFGHDRTQLLSQVEPSSSSSNMHVLPTMSELTYALSSNMSSLKTVAASYYPSEFVHESVDTSHQGPLFSSYSNVLMHKPSSAISQADSLLQPTRSLSSEMDWSEAYSGSESLLPDTDILPMLKVSSHDSSGELISSTPGYTGDVETPPKNGAIDGSDKELQISSSFSEMPSLAEIEMAELTTTVSNDEITKQDATLQEILLTVSSAKGVLPVSIAFPVNKVFDYDARKLSESHVPIQPLHVTTPAFDDTLLKPLLNVFSQPASLTPASSKILHPSTEQYFYEASATLKNNALLQTSFQSSDDDKQLRSPITDYSNPVLTENNRRPNNGSSVFDQMTLDSAANNTKMHSTSAPSAVNTSYTTSSLTNLQGFTLGYISDEHSSPRLPNSEDIHQDAPSLYSNEVSYQSTRVENKSVPSFKVVNTMAVPVLPTDTLPNVATSDVLLTSSASTNIVDVTVPVPETISDSIKHNFRSIPDMQISTTVDSARTKASTIFKMLLVPTKVVTEKSTTTSSITDLWSSIVDEDYDEYDSGIPVNGCHRCLSHRETQEEVDEPDTQVDSTNNQYSLITNSHFETSEEEEKKTITALLHHTLTNEMDQLKYPSVPAVASNTKTKKHSDSAILNNQIQTFREPLKKAPESKSWAVFTSDEESGSGQSTSDSINDNETSTDFSFADVNDRDSEGVGGAGNSDLTSGSQQSSVASVNSDSSVFNVSEAEASNSSLQSRIGLPEPKTVIPLVVVSALTFICLVILVAILIYWRKCFQTAHFYLEDNTSPRVIASPPAPVFPVSDDVGAIPTKHFPKHVLDLHASNGFAEEFETLKEFYQEVQTCTVDLGITSDSSNHPDNKNKNRYINIVAYDHSRVKLAQLTDKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSIHVLAYYTVRNFTIRNTKVKKGSQKGRPGGRVVSQYHYTQWPDMGVPEYTLPVLTFVRKVAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNRNYLVQTEEQYVFIHDALVEAILSKETEVPENHIHAYVNSLLIPGAMGKTRLEKQFKLACRHTHAHAHTEKPRFLRRSGDPLWRAFLTWMWDSYVVMQRSKILKLELEQCRLEQLNSRILPILERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQIIVMLPDSQNMAEDEFVYWPNKEDPINCESFKVSLISEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELINVIKDETSNRDGPMIVHDEHGGVTAGTFCALTTLKHQLENENCVDVYHVAKMINLMRPGVFIDIDHYQFLYKTILSLVSSRQEENPSVSIDSNGSALPDGNAAESLESLV
The following text describes a protein:
Function:
Not known. Binds calcium ions.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence:
MKPLLLVLALCGAQVHAHSVGLRPDYNDYSDEDTRRDWLPEPLKPVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAPEGANQLPVLVFVHGEMLFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSGVWPQATSEYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRVIYKPTTNFSPPITTTTTTTTTTTTTSRPYAYNPYANWQNRPSQQHPNWHPADPEYVRAQEARQQEFIREREQRRREQQLRDQQRYPQQEPREQQDERIRQQREQEERLRQQREQEERLRQQRELEERIRQQQEREQYEREQQEREQREREELERQQREREQQQPEQQPEYNPEPVNPWGYPVQEPQPDDNPEDGRLPYPSYEQYGPEGNENLPETDANRNFSEEDREQQQQEQLRREQQEQQEREYQLQLEREQQEREQQERGQQEPGPEEYPSYEEYSRALQEKNAERDRIYAEEQERERQQQETLLQENQQHPEQSLPEEQPTHPNYEAYDGDRSYAEEQEREQQRRDQVEQEREEQPDEDQGEEYERSPDEEEAAEQDVLKVEDFPSYEAYLEAATKLREEQEEQEKLEEERYRAQQEEEDRIQAERERNSRN
The following text describes a protein:
Function:
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.
Subcellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.
Sequence:
MELHVYIAHTGQHLQVDPGSFTSLDDFKKWVAKYTPIAASDHISLTAAAKAVRFQALSSEQEIFVYDRRIIQQSSIASAKSLISEIPLPRKYTVSQPPDSITNEKNLQAWKDLFAERRAWAVKVVDDCAAMSDQAQQRYIETEVITRCVDTAVLNLEKHVKALDQKNAEVQNDVEEMQKLNTTNRNWEASISRLKSLPASADVIKFITGRDLSNMQRPITLGDLIDAEEVKRSGKMLRNISTNLEQKSVEVGQDVDEVMRRIDLLIEKVEKSPARAAIPHAQEPISLMEDIEAISKKVNTDCETVLGFANTPKNISQASKSALLHTEKFLPSLSKRALEMEGMVQTVTKLRNSTAISSLEFMYDIASLTTMLAEVNGRFAALELDSDVIDALHMISMLDTLPVTYASFLAEAVRRSEWDEKVKSDSSTLANEMANFQEEETRRRRKWQKNIGATLWEEKPETQVMALEVILHGEKDDWPQASRRDLEEIFEILKADDSQSPIVSDISRIISDLNNPTRQQSRRANAFKAGSIHESALGKSALLMRGDNDVLKSLQDDKLKLENKLKTAESRVRRLEDLFHRQTQVSRTSSGNVFPVPNNPSPDVQNVANPMASPRLNDDSRRSSISSRRFSANRGEEEKAFQQKLLSLEAELIAERERALGLEKEVSAKNTSMSELNSQLEEVNSMKQDLSENFKAQQRDFMEERKSLEVEIKRLKARLEELEDEIDRYIGSRENEKSDVDDRLRLLQGELEKLRKDAAAEAQKAQGQVDFLRNDAKLQRETNETLERQMQSLREEKKELMSRTIQAESLAEDQLKALQDMHLQLSPKLRMPQEFTALSGSLTNKSLNLLSDLENTKRDYNLAKSQRDDAETTISELKDELTKYREKFDREEKASRSLREELASEKAKFTALEAELTDERLQLSSLRTKMADGETGSEALRSRLEEEERKVTSLSEDLAGQLSRIGSLEEETRSHTEKNQFAQERFERLNSRFDSRTSRAKDLTQRLYSQNDKLVRLLERLSYSVTKENGSMIIQKLPKPDRSIINGNDSSDAGNKIRRSMTGSTTMRAMIDSGDLDLLYWMHNDDPEAEGEKYDAYINSIGSFDVDNFCEVIAKRVRDIEYTAKKYSKDARSYREKSHRAQKEAHEKIAFKNFKEGDLALFLPTRNQSTGAWAAFNVGAPHYFLREQDSHKLRSRDWLLARIHKIEDRVVDLSKSMTDGRSFASTGGDSFEDDNPFDLSDGLRWYLIDAAEEKPGAPSTPGLAKSTVASANIDATATIRRSKKSSTTGAEGLNKTLAKSLDSRRSSSTSKKAIPAASIQLRKTDSTASVSGLRNEANDDVTSTGADSILVRNVDGIADGKANSEVRNPLDNLLGP
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Sequence:
MTIPNAPAPTAENASRLPAEEARILSELATNPNETDSYFAVSKRSSLLPNLDSASWCDSNVCVCRWYKSWQKYVDEPLGGGGAAAAPRPGPIDNSDIIETDGRSLAVKEKNYLLVNQQVWKTLVEWYNGGPPVPRTFIILLLSHARDDDVTFIRLPKQASIRELYQKVCARTGVSQEKARIRDYYNMSKGQLLDPLSNKSLEESGLLMNRDILLEVEERGLAGLVNLGNTCYMNSAIQCLAHTSPIHEYFLRDHTHQAELARAFGELLKELWSSGTNAVAPRVFKTKVDKAAPQFTGHYQHDSHELLLALLTGLHQESDIVNVFQGQCKSSLVCPVCGETANTYEPFTSLSLPLPSTPTWSISLLSCLDEYLAQEPLGPDNMWLCPQCKEQRQANKKLDLWKLPEILVFQLKRFKTSKYFVKKIDTFVDFPVDELDLSKYVEKGESCLYELYAVSNHDGGIGLGHYTAYAKMIDDDNEWYCYDDSLVSPVHESEIVSSAAYLLFYRKRVGSDMDLS
The following text describes a protein:
Function:
May function as an ATP-dependent RNA/DNA helicase. Binds DNA in vitro in a non-specific manner.
Subcellular Localization:
Nucleus.
Domain:
PH (probe helix) motif serves as a DNA recognition helix.
Sequence:
MAKKKKDTKHTRLCEATGAWATKVLEDFRASGNDSYVFEQQLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFKGDGISKSDKRRMYEARNQKEKEGDGISKSYSKHRYETRFQKAGGIRKTRISPKKLKCVSFPPEAKAVLHDLFTRYPPCDGDTTGTSLGIYTTGNVNSNWKDDFFKKPHMTKHDIENNVVSLSSRLKKERHFREIFEARSKLPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKEACKIICTQPRRISAISVSDRISWERGETIGRTVGYKVRLQSEGGRESSVVFCTNGILLRVLIGKGVNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSATLDAERFSEYFGGCPVVRVPGFTYPVRTFFLDDALSVLNSDKNSHLLSAVKRDFKDEDKVSLDEAIDLAWTNDEFDCLVDLVSSEGSHEAYNYQNSTTGLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELAEKENQFETAQIIREHAGNIQSNSQQAQDLLDKYMATIKPEEVDVGLIVKLMKKICSDSKDGAILVFLPGWEEISKTKEKLLDDRFFAHSAKFIILCLHSRVPAEEQKKVFNRPPRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQRAGRAGRCQAGICYHLYSKLRAASLPEYRVPEVMRMPVDELCLQVKMLDPNCNVNDFLQKLMDPPVAQSIENALIILKDIGALTPEEELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFTMPLSPGDRKKAAAAKHELASLYGDHSDHLATVAAFQCWKNAKASGQAKEFCSKYFISQVVMKRLDDLCRKLQGELNRHGVIPSSSSNCSLNAHDPGILRAVIAVGLYPMLGRMCPLSKNRTRSVIETIAGAKVRVPSLSNNVDMSSTKFDEALIVFDEITRGDWGVVIRSCTVLPTIPVLLFSREIAVSTTESYDAVKSDDEEDHKVGNVGDAMDIDKEVGRPGEKIMLGPENSVKVVVDRWLPFKVTAFEIAQMYILRERLMASILFKVKHPKENLPPHLGASMYAIASVLSYDSLAQSSVQTVAVQPITSVVDATSPRDDIPSTNPNELREHDPNTTPMGSKLELANKLGLGNMEESLPSNFADGNEQPDPNTSPVEDVSAATKQKKMQSESKRCKSLNNVDLGNIEENFGNMEENPPSDLAIGNEQTLPKLASNLDMGNMEENTPSDLANGNEKTEPNSANSMDLGNMEENTPSDLANGNKKKEPKSVSKLDLGSEKVSIPSNLVNGNEQHDLNIAPGEDASAAKQPEKKRSRSKKRKSGNNLDLGKMEKSKPSDLANENEQTEPKSANNLDLGNMKENTPSDLANENEQTELRLPNNSDYGNMEESLPLNLANGDEQPDPTTAPMEAAKQPKKKRSRSKKCKSVNNLDLGNMEENKPSDLANGNEQKDPESVNRLDPGKEKESIPSNLVSGNEQPDSNTAPAKKPKKKKRKLANNFDSVNNMEEKMPSTNVLSQGNKSGLIEEKPSIPSDQ
The following text describes a protein:
Function:
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.
Subcellular Localization:
Nucleus.
Sequence:
MDSDEIMPDEEHPNVPVGDEESDIDEKYPNRPRNHSPTLPFHELFQTLFNPLGEIKKKPAGAVAARRKVGPHGQSAANLNPLERRRDVIERFISRWRKEVGDDIYPAFRLILPDKDRDRAMYGIKEKAIGKMLVKIMKIDKNSEDGFNLLNWKLPGQAATSRMTGDFAGRCFDVISKRPMRTDVGDMLIEEVNEKLDKLSAASKEEQQLPILAEFYRRMNPEELMWLIRIILRQMKVGATERTFFDVWHPDAENLYSISSSLRRVCWELHDPNIRLDAEDRGISLMQCFQPQLAQFQMDSLDRMVARMRPTEEDPVFWIEEKLDGERMQLHMASDDSVPGGRRFRFWSRKAKEYTYLYGNGIYDENGSLTRYLKDAFADGVQSLILDGEMITWDPEQDAPAPFGTLKTAALSEQRNPFSTTGARPLLRVFDILYLNGRDLTGYTLRDRRKALQKAVRPVHRRFEIHPYEEATTKDQVEAALRKVVAEASEGLVLKNPRSPYRLNERHDDWMKVKPEYMTEFGESLDLIVIGGYYGSGRRGGNLSSFLCGLRVDDGHASQGASASKCYSFCKVGGGFNAADYANIRHHTDGKWMEWNPKKPPTAYIELAGRDAQYERPDMWIKPEDSVVICVKAASVSASDQFRLGLTLRFPRFKRLRMDKDWKSALSVQEFLDLKSNVEQEHREKELNVDNSRRKRVKRTAKKPLTVAGYDMDEDVKYAGPSGHIFDGLNFYILTDSSAPIKKTKPELEQLVKANGGMFFQTNNAAPHTICVADRRTVKAASLQKRGDVDIIRPSWIIDCVKQNEIDAGLPDFLLPFEPRHMFFATPGKHDEVASNVDQFGDSYARDTTSEELSDCPESITKLIERLQESVNSGHEMPCGLLFKSLTILFPHRNDDVSESEAKTSSHPSITHVVIDPESSSKEISSLRGKWSRKPGRKVPHIVTVDWVEESWKSRTLLDEERFQPKRCISGIAKPYWPG
The following text describes a protein:
Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
Sequence:
MIKAILIFNNHGKPRLSKFYEHYNEDTEQQIIRETFHLVSKRDENVCNFLEGGMLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIITQVDAQNKMEKAEAGIAGAPARAVSAVKNMNLPEMPRNINIGDISIKVPNLPSFK
The following text describes a protein:
Function:
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence:
MPSKRQMLKQVALSPLSLLSLLPIPSPQQLLLSTLSLGPIPRHIAFVMDGNRRWARTSHHSIQHGHLTGFATLKSVLEVCLNLDGLDTVTVYAFAIDNFRRSEAEVSTLMQIAKTRLIELAGHGELIARYSVRVRIAGRKDLLPADVREAVERMENMTKHNTRATLNICMPYASRDEITGAARTCLDRKLRHVERAAVAAQAQQIAQNNSHSSLHHLLDDIDFSISAQDLEHNMQLAHSPPLDILVRTSGVSRLSDFMLWQCTDSTHLHFVDKFWPQFGLVDLIPIILEWQRQQWSLSIRKSCGWQ
The following text describes a protein:
Function:
Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction; Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity (By similarity).
Subcellular Localization:
Cytoplasm.
Domain:
The N-terminal region consists of two globular folded domains that contain prolyl isomerase and chaperone activities; The C-terminal region binds nickel ions.
Sequence:
MKIANECVVNIEYTLRDDTGEIIDSSDVMGALEYVQGHGMIIPGLETALINREEGEEFSVTIPPVGAYGEVQEDLRMTVGRDQFPPNVPIEVGMRFDAGSGGDSRPVTVTDVQGETIIVDGNHPLAGKTLHFEVAVRSVREATDDDLAALLFRESTSGGGCGSGAGGCGSCGAGCH
The following text describes a protein:
Function:
Acts as a transcriptional regulator. Involved in postembryonic mesodermal cell fate specification. Activates ceh-24 and egl-15 during mesodermal patterning.
Subcellular Localization:
Nucleus.
Sequence:
MVARRKGERVVRKNEVENVQQRACANRRERQRTKELNDAFTLLRKLIPSMPSDKMSKIHTLRIATDYISFLDEMQKNGCKLYGHSIFDEKRGYNLQSAFNMWRGNNGYTPIAGPSQLPPLQSAHIPPPAPSSIPPHCLMPQPWYQTCPPPKQEFHELCPISTPNPNSNPNQLTPIHWQ