lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
F-box protein component of a SCF ubiquitin ligase complex involved in ubiquitin-dependent protein degradation. The SCF-DIA2 complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSEDIIDRSLELGIQCFQGEDYKGAAELFSKSLQLARSYTDRSLEGIREKVGLPKRCLHDPSRVYHPRYLVLLDNRAATWEKLNKLDRALADAAYMITVDAYNLKGYIRRGKVLQKLGRYEEALQVYENGLKQAGEAEKTHAIHAPQKFLDIVYRQRSTIKELLQSRARSSRSLTQQTVAKEPKLKRPATIDSLMPGKKRSSSKAKIDYIATLPVEIIERIMANMDTRSIIRCYSVCKLWKYRLERLPHLYQEFRLSCCYKNMLGYVNFVGALASRTAEYSCRSIQCVSGNVQEEEKSIILLLSRLMIGTRQLALMAKKCKAERIIQHICENKKLRNGVQRLSITAPVHFGHKLNLHELYTRTTSMTHLELVLNFHTPSEHVGGHLFPWQDHAVAETNLESFTLMARNYSVHHVNVIEQFEYSSVLFKRLKKLCITGIDFRLGDRNNLKWISDMPNLQELWLERNTGIEFHELITQIVQVGAPKTLRHLTFREPPNRHFDRMDQSQLGLGEEALREVFQSLESLDLMNTRFDPQLLLLLLQPACENRIARLNIGNCPRLSFARDLEILTLIFQQLPALTDLLLPNVMEYTRQGMEVLRKNIKGMKLKRLDLSFIPSLKGYELLDLLKELKGINPLGLETLTINGCTAVAPQTVDYITRNGYAQKVMCAYERTQWEHLGINSFWYR
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also partially utilize GTP, CTP or UTP as phosphate donor.
Sequence:
MIENYNDIAITDTRRKILNIIDKTLIAMDPENAIKNFIEKNNIKFDSKRIFLIGFGKAAFKMYSGIRPFILKDLVYASIIVPDDEKTNDYNELRILRGTHPFTGDLSVSSSISMLSGLKNLNENDLVIVLISGGGSSLFEIPEDGINIDDIKNISKTMMDKGCDIYELNMVRSMLSKVKGGKLATMLYPARVISFIISDVKNDDLSIIASGPLTRIDYRIEDLMETIKKYLGNDERIKMYRNIDDIYFNNVKQYIILKNRDFLDYIYSNINDDAVNLGSNFSGNVEDLSLILHNILKNIYSSKRKPFYFMLGGETTVDVKGHGSGGRNQELVLRFMKNSSNSEVYTIASFGTDGIDGVSPAAGGIVDSDHEIDNINEYLNRNDSYNLLIKNHGAIITGRTGNNVSDIIIGLYYNK
The following text describes a protein:
Function:
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Subcellular Localization:
Membrane.
Sequence:
MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIRVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMCRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAQVSRVHNLAQSTQIFGHSSNPNEPKSANSVSLRPRLWGPSKSRILVHKTGSLMGNFNAGKGNSGMFKVSASVAAAAEKPSTAPEIVLEPIKDISGTITLPGSKSLSNRILLLAALSEGTTVVDNLLYSEDIHYMLGALRTLGLRVEDDQTTKQAIVEGCGGLFPTIKESKDEINLFLGNAGTAMRPLTAAVVAAGGNASYVLDGVPRMRERPIGDLVAGLKQLGADVDCFLGTNCPPVRVNGKGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSVEHSGNWDKFLVHGGQKYKSPGNAFVEGDASSASYFLAGAAVTGGTITVNGCGTNSLQGDVKFAEVLEKMGAKVTWSENSVTVTGPPQDSSGQKVLQGIDVNMNKMPDVAMTLAVVALFANGQTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCVITPPEKLNVTAIDTYDDHRMAMAFSLAACGDVPVTIKDPGCTRKTFPDYFEVLERFTRH
The following text describes a protein:
Function:
A methylase, recognizes the double-stranded sequence 5'-YTCGAR-3', methylates C-3 on both strands, and protects the DNA from cleavage by the BsuMI endonuclease.
Sequence:
MTNFILNENKQLSLAIEDENIENFYIDGTDLVRKIIRRSGSGVTSRVPVLSTQDLENKNLHELYDESWLRMKNRPNTELTTESINIADLFSGCGGLSLGVWEACRALGINPRFSFACDLNEAALSVYEKNFSPDFSLNESIEKHINGELGAPLTVEEQRIKDKVKKIDFILAGPPCQGHSDLNNHTRRKDPRNALLMRVSRVIELFQPSSVLVENVPGIIHDKSGSFKEFKNHLKTQGYYFDEIVLNAEKLGVSQARRRYFIFASKTPVSSLNQINEFYSTNSRPISWAISDLVENVGDDIFNTASEHSLENKRRIEYLFENNLFELPNSERPDCHRLKPHSYKSVYGRMYWDRPAPTITRGFGSTGQGRFVHSLLKRTITPHEAARIQFFPDFFNFGDLRRRQYQDVIGNAVPSKLSYLLALHQLR
The following text describes a protein:
Function:
Flippase that catalyzes the transport of undecaprenyl phosphate (UndP) across the cytoplasmic membrane, from the external side to the cytoplasmic side. Is involved in UndP recycling during peptidoglycan synthesis.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEQIITEFISRFGYAAIFILILLENVLPIVPSEIILTFAGLMSVKSHLSILTLFIIATIASFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIPVLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIMYVVIIIAVIYFAIRYIGKRKRVK
The following text describes a protein:
Function:
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MSYPKARIRRFFRQHCQRSLESSALDLVYLDYCLFLQSLLKEANIEAAKTGERRVQPEHVRSIQRKILAQFKG
The following text describes a protein:
Function:
Uridylates small RNAs to trigger their degradation. Catalyzes the uridylation of 5' fragments produced by AGO1-mediated cleavage of miRNA target RNAs. Acts synergistically with URT1 in unmethylated miRNA uridylation, leading to their degradation. URT1 and HESO1 prefer substrates with different 3' end nucleotides and act cooperatively to tail different forms of the same miRNAs. URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1. URT1 and HESO1 are involved in the uridylation and clearance of RISC-generated 5' mRNA fragments. Able to act on AGO1-bound miRNAs and the uridylated species stay associated with AGO1.
Subcellular Localization:
Cytoplasm. Cytoplasm, P-body. Nucleus.
Sequence:
MSRNPFLDPTLQEILQVIKPTRADRDTRITVIDQLRDVLQSVECLRGATVQPFGSFVSNLFTRWGDLDISVDLFSGSSILFTGKKQKQTLLGHLLRALRASGLWYKLQFVIHARVPILKVVSGHQRISCDISIDNLDGLLKSRFLFWISEIDGRFRDLVLLVKEWAKAHNINDSKTGTFNSYSLSLLVIFHFQTCVPAILPPLRVIYPKSAVDDLTGVRKTAEESIAQVTAANIARFKSERAKSVNRSSLSELLVSFFAKFSDINVKAQEFGVCPFTGRWETISSNTTWLPKTYSLFVEDPFEQPVNAARSVSRRNLDRIAQVFQITSRRLVSECNRNSIIGILTGQHIQESLYRTISLPSQHHANGMHNVRNLHGQARPQNQQMQQNWSQSYNTPNPPHWPPLTQSRPQQNWTQNNPRNLQGQPPVQGQTWPVITQTQTQQKSPYKSGNRPLKNTSAGSSQNQGHIGKPSGHMNGVNSARPAYTNGVNSARPPSKIPSQGGQIWRPRHEQ
The following text describes a protein:
Function:
Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.
Subcellular Localization:
Vacuole.
Sequence:
MAPLKISIPSANEKTPEGGKPYTAYTVKIEHAFPRAATSVSKRYTDFSTLDSALRSSVGSAPPVALPAKTWGIGGFLGLGGGTATPDAIEKRRVGLEQYLRAIENAEDGRWRVSRPYRDFLELDDKDAKKPASFPGSQFGKDRVRDSSDWLDKHGALKSSLQDARRCLTAREQAIAATAQHEAAANAKKSLLRASTLLSALDEGLGRLSGSSGDEWSGEKLGEGEIRRRRDMISSMRKEKDGLESVLNSMAVKAAMSGSSSTPSTSSAAVTQEQKAGLFKGAQSSGRRVLGAPQETERTRELDNEGVLQMQKQIIQDQDEDLVDLTTVVRRMRDMGVAINTEIVEQNAMLGLLDEDVERVDGKIKIAKKRIAKIR
The following text describes a protein:
Function:
The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
Subcellular Localization:
Cell membrane; Single-pass membrane protein.
Sequence:
MMTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGDSVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE
The following text describes a protein:
Function:
Siroheme synthase involved in methionine biosynthesis.
Sequence:
MQLLTAQKIDGHRHIITGQSNLAFSRAQRSLECGAQPIYVGTQLPEALKDLVKTGKVEHVDESFQFRHVTSLGRDEVSGVVDQVLVVGVHQHEEVDLGSLYRQCLSLRVPLNVAGHPEYCSFTFLASYADGDFQFGVTTSGKGCRLANRLKREMVAALPANVDEICNKIGSLRERIYEEDLKDVFEAEDIGQEDDDAEQKRLNVLVVEDSETFIQKKKQRLRWLSQLVEYFPLGKLANVSIDDLNRAYHSSQEADAKESQQNGQEDDSAPAVVDSSSSSSKAHIALIGSGPGSAQYLTSAALERINSADLILADKLVPESVLDLIPRATEVFIAKKYPGNAEAAQTELLERGLDGLKQGKMVVRLKQGDPYIYGRGGEEYIFFAGHGYKPEVVPGITSALSAPLAANIPPTHRDVADQVLICTGTGRKGAMPVIPEFVKSRTVIFLMALHRVDRLMEAISATPGWDLSTPCAVIERASCHDQRVTRTTLQYLVEAVEAIGSRPPGLLVVGHSCTILEKLDEGQKWKIEEGYHTGVGETLKGFSALA
The following text describes a protein:
Function:
Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as a negative regulator in abscisic acid (ABA) signaling. May function as the substrate recognition module within this complex leading to ABI5 degradation. Functionally redundant with DWA1.
Subcellular Localization:
Nucleus.
Sequence:
MQGGSSGIGYGLKYQARCISDVKADRDHTSFLTGTLSLKEENEVHLLRLSSGGSELLCEGLFSHPNEIWDLASSPFDQRIFSTVFSTGDSYGAAIWQIPEPYGQSNSSTLECVASLDAHVGKINCVLWCPSGNSDKLISMDEQNLVFWSLDSSKKSAEVLSKESAGMRHSLSGGAWNPHDVNSVAATSESSIQFWDLRTMKKNNSIERAHVRNVDYNLKREHILVSADDESGIHLWDLRKTKFPVQELPGHTHWTWAVRCNPEYEELILSVGTDSAVNLWFASASSEHKTSESPVEASRQRVNPLLNSYTDYEDSVYGLAWSSREPWIFASLSYDGRVVIESVKPFLPRR
The following text describes a protein:
Function:
Function as phospholipase selective for phosphatidylcholine. May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MWFAARPGNEHCQVPAPEARPRRRGPGVLVPEWRKVAERPQGTVRARADRRRETDGQPGGWHRTDARSGRLCPVELRAAPASRLRAGRRGGPRAAGAGQDRRESRGGEAGGPSRPRGQALCARPALALWGVDSSSGSAPLPQLAKPRRRPLGLSGMAATPQSLFPSGDDLDSSQLQMEPDEVDTLKEGEDPADRMHPFLAIYHLQPLKLHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLLRHKVFMSLLPLARFAVASSPAPEGDSREIPSLPRAGPEGSSRRTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGCKGLEGVIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFKVQVGKRSTEARYGVRVDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFIQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKKKAEEGVHVSVLLFKEVELALAINSGYSKKALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAAPQPPTSCSDLPATPDLTHNQLFWLGKDYSNLITKDWVQLDRPFDDFIDRETMPRMPWRDIGVVVHGSPARDLARHFIQRWNFTKTTKTKYKIPIYPYLLPKSTSTANQLPFTLSGGQCATVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGQCFRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTEWRNYISVCGLRTHGELGGHPVSELIYIHSKMLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTEMEPSLMNGVEYQAGRFALSLRKHCFSVILGAAARPHLDLRDPVCDAFFQLWQDTAESNANIYEQIFRCLPSNATRSLRALREYVVVEPLATVSPPLARSELNQVQGHLVHFPLKFLEDEYLLPSLGSKEGVMPLEVWT
The following text describes a protein:
Function:
Mediates the uptake of pyruvate into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MAFFRAFLNSPVGPKTTHFWGPMANWGFVIAGMMDSRKPADAISGNMTAVLCVYSLLCMRFAWMVHPRNHLLLAFHVSNESVQLYQLSRWLKHQRYLPPKEDNVS
The following text describes a protein:
Function:
Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1.
Subcellular Localization:
Nucleus. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (By similarity).
Sequence:
MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGGKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLLSTPPSRPPQVKTATLATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQPPPPPPQPQPQPQAGPRLPPRQPTVASSAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKDEELLKDLEESVQDKNANTLFSVKLEEELSVEGSTDVNADLKD
The following text describes a protein:
Function:
Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks.
Subcellular Localization:
Chromosome. Note=Recruited to replication forks.
Sequence:
MSGESDQPQPGPSHAGLYLEHRERDQAGVPGGVIRRAGSQRHRSWIQTVIEQITGSPRQCVTLSEVVPVSVLAVQRYLLEDEPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNFLVYQNILKVGIEMRISRVSCLYNEKRLGQGILCIDKVHCGEPLDVISVETPFRNRAHEEKPERPLRGSKSHYLALWNNEDPYGDIWKTNKQPEEFNFNNTKIISLSHLEMTWHNRKNFPALLVRILHKSKLRYYGKPNKKMIEPYQTYLEVADSSGMVSVIMWNALCPEWYKSLRVGLILLLQDYSVKKSYPLRIQPDPVDPQMKLISTMEICLNLRDPPTNIVIIPEKQLKSEWKLPKLINRFITRSELDDMPENSICDVIGMLSFVGRVQRSKKKENSEDFWSYRWIHITDGTSEQPFIVQLFSTSQPEVFENIYPMTYFVCTQLKVVRNNSQVPKLLYLTTTNESRVLITGHRGQPYTYDTKAKKIIQWIKTKTNLEAKNTVIGGYYPYPPVPETFSKYSRFIKAESLLTTISEVRKVIEDLQYREQKRIAIQGIITAIKYIPYNHSAKSAPASETLQNASPPSTSQAAAKEGHYHERGSKRSQDDRPMDSLPMVLSLCAKRKILQGPTANPVPVPQPHSSAQMKGNKPNIPSRENSTANATGKSKRIINDRWESQLWRDKKFSLRDHLHYGHVDPESIPRKFILGHEKFLTQQFNSQPAKYVPPEGKPPKLDEFQSARSLGHFEVTILGLNHEIAIDVAFLPMYSPEDVETSQIDTFLTCMNYSCVYPPAAPVSGRVPDPKAVAGDIVKAAADLDRVHIIGILDICNLGNNKVEVCLQKIYTPE
The following text describes a protein:
Function:
Involved in telomere length regulation and required for survival upon exposure to K1 killer toxin. Promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase.
Miscellaneous:
MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MSSTSDNNANSAREKKPLKFVSEGVGNVEAQRIREQVEQKKYEAEYKRKTRKSLRDQLRSNAISKQKQYNGLVRDRESFTRLSKEDLEFYQKSKNELLKKEKELNNYLDVKAINFEKKKKALLMENDSTTNTEKYLETGTSLGSKTQIKGVKTSSPKPKIKVSIKKLGRKLEN
The following text describes a protein:
Function:
Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity. Enables the organism to utilize D-amino acids as a source of nutrients (By similarity).
Sequence:
MSAAPPRRVVICGGGVVGACTAYFLATHAASPTVPTLVERCAPACAASGKAGGFLALDWCDSTPALSRLARASFALHRRLADALGGADAYGFRPVHTLSVLLPPHPAASSSPPHPLLPPWVDPSASAAPPRELGTPDTTAQVHPGLFTKAVLAASGAEVVIGEVERVAVAWDGRVAGVVVKGRDGVLDADAVVLALGPWSGRLEVVSEVFDVSGLKAHSIVLRPREPEKVTPHCLFLSYQPEPGAKMLDPEVYPRPTGEVYICGMSKDENPPDDPATITGEPDSIAMLHKIAGKVSSQLKKEEGAEVVAEQACYLPCTADGLPVIGEIPGVKGCYVATGHSCWGILNGPATGAALAELILDGKAKIVDLEPFSPARFLKRRSRRGV
The following text describes a protein:
Function:
Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (By similarity); May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis.
Subcellular Localization:
Virion tegument. Host nucleus.
Domain:
The transcriptional activation region seems to target many proteins of the RNA polymerase II transcription machinery.
Sequence:
MDLLVDDLFADADGVSPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSGFPTNADMYRECKFLSTLPSDVIDWGDAHVPERSPIDIRAHGDVAFPTLPATRDELPSYYEAMAQFFRGELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRNRDLREMLRTTIADRYYRETARLARVLFLHLYLFLSREILWAAYAEQMMRPDLFDGLCCDLESWRQLACLFQPLMFINGSLTVRGVPVEARRLRELNHIREHLNLPLVRSAAAEEPGAPLTTPPVLQGNQARSSGYFMLLIRAKLDSYSSVATSEGESVMREHAYSRGRTRNNYGSTIEGLLDLPDDDDAPAEAGLVAPRMSFLSAGQRPRRLSTTAPITDVSLGDELRLDGEEVDMTPADALDDFDLEMLGDVESPSPGMTHDPVSYGALDVDDFEFEQMFTDAMGIDDFGG
The following text describes a protein:
Function:
Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MASKYQSVQPGGSLIIAWRAQGKKVLIVGGGVVAAGRILHVLNADAHVIVVSPKAGLCKEVAWRIQEKQVEWRDRGFLVEDLSDDVNMVLTAIDDPSLSSEIYKLCKSKKIPVNAADIPPECDFYFGSEIRNGPLQIMVSTNGKGPKLASLIRKKIESSINPATGMALEKTGLLRQKLRDIVPEPENSRKRMRWMIEICELWSLEELAMLDENLINRLLGYFPKKTPSYREITTPAYSKIDNYIWFGAIIISGAVLLKHVSKAR
The following text describes a protein:
Function:
Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSCHVLSSVNICCSKLVKRRLQQGKVTIAELIQPAARSQVDATEPQDVVVYDQSTRDASVLAADSFLSILLSKLDGCFDSVAILTGGFATFSSCFPGLCEGKPATLPSMSLSQPCLPVPSVGLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRIPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKLLAALQSDGPHLGTPEPLMGPAAGIPLPRLPPSTSESAATGSEAATAAKEGSPSAGGDALIPSTAPATSALQQGLRGLHLSSDRLQDTNRLKRSFSLDIKSAYAPSRRPDFPGPPDPGEAPKLCKLDSPSGGTLGLPSPSPDSPDSVPECRPRPRRRRPPVSSPARSPAHGLALNFGDTARQTPRHGLSALSAPGLPGPGQPSGPGGWVPPLDSPGTPSPDGPWCFSPEGAQGPGAVFSAFGRASAGAPGPGSGSSGGGGGSSSSSSSSSSGDLRRRDVRTSWPEEPAADAQFKRRSCQMEFEEGMVEGRARGEELAALGKQTSFSGSVEVIEVS
The following text describes a protein:
Function:
Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteasomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.
Sequence:
MVIGLSTGSDDDDVEVIGGVDPRLIAVQENDSDESSLTDLVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRNRLRDIHATSIRELEDGLAPELREELDRLTLPFNEDAVPSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLQQMRQGALPPGVGKSGQHGHGTGQYL
The following text describes a protein:
Function:
Probable carboxypeptidase.
Subcellular Localization:
Secreted.
Sequence:
MGLFFYTKETNLPPHPHLFLSETSLLSSVIFPPETMHCPSRKIIATATALLQLFQFMGIAASLSLSDRITELPGQPQVSFQQFSGYVTVDDKRRRDLFYYFAEAEIDPASKPLVLWLNGGPGCSSLGVGAFSENGPFRPSGEVLVRNEYSWNREANMLYLETPVGVGFSYSTDTSSYVAVDDKITARDNLVFLQRWFLKFPQYKHKDLFITGESYAGHYVPQLAELIIQFNKKEKLFNLKGIALGNPVLEFATDFNSRAEFFWSHGLISDSTYKLFTSACNYSRYVGEYYRGSISSVCSRVMSRVSKETSRFVDKYDVTLDVCISSVLSQSKVLNPQQVTERIDVCVEDETVNYLNRRDVQKALHARLVGVRRWAVCSNILDYELLNLEIPTISIVGSLVKAGIPVLVYSGDQDSVIPLTGSRTLVHELAMELGLNTTVPYRVWFAGQQVGGWTQDYGNILSFATIRGASHEAPFSQPERSLVLFKSFLEGRPLPEVF
The following text describes a protein:
Function:
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
DRRVHDGKVSDKEHFSKTGVHNPEYDHDAFLGQDKKEFDSLTPQESKRRLGLIVDRIDKDQDGRITYTEMKEWINYAGNRYAFDDGDRLWKAIKKREEQIAKKENKSFNPDAPIDWDLYKEDAFGKTITDANEKRYQRDRKQWEVADRNKDTKLSKEEFPALFHPSVFDYMQDLVLDESMLDIDTNRDGYISQEEFLGKATEEKGTEEEKEMIARRRQEFLEHRDTNKDGRLDRRELKDYLFPAYDHVGAEAQHLINEVDKNEDGMLTKDEIMDNFEKFVGSRAAEFGQALNRHEEF
The following text describes a protein:
Function:
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Subcellular Localization:
Cytoplasm.
Sequence:
MVCDPNGDDTGRTHATVPVSQLGYEACRDELMEVVRLLEQGGLDLDASLRLWERGEQLAKRCEEHLAGARQRVSDVLAGDEAQNG
The following text describes a protein:
Function:
May be involved in intra-Golgi transport.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type IV membrane protein.
Sequence:
MAVASEALLQKLTESWKNSRFEELQREADEAAAEIEKMQKTSLDERKELSSKTKEFRKQPDEVKLGEMKGLLKLYQSGIDSLTKRAKSAEATFFRVYETLGEVPDPYPLLIEAANNLKTQKQIEDLKKEKEEMEGSLQGKEKLEREVENLRKELDKYKDLVETEAEKRAAITKEECEKSWLEQQKLYKDMEQENASTIQKLTSKIRELQASQLDHDLQASQNESAGLDVNAKSAEVNAILSELDDANKIIVELQAEIAVLKQNTKEQKSGSSQDDLSNQQKQQLDFMDSLNKKLSTELESIKEASRKEMETHCATIQTLENEVKEARKVKEESLTLANKFSDYDEIKRELSVLKQIEFSGEHATHENTSLESQLLKREKQLSEELAKLRSTNAQLTDRITQESKKASFLEQKASEQEEVIRKLEKDLADVDVEGSVYLSNTTYRREGTSGQLSPTSSIMGGNPSLFNGSVLSRNSVNETGSAIVDVIKQQRDRFRRANVTLVNQVSAANDKIALLESKLEEVEKSNTLLYEQMRFRDHYQKHVEPSSSHLQTAAAYENSISPFASFRKKEAERAYSRMGSFERIVYALLRTLLFSRATRGLFFMYLILLHLFIMIVLLKLGIAGNTAYTPMNY
The following text describes a protein:
Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAGVKSDWWAGSHREPPKAKTKNLPNLKKTTVYNQGRKGSPMATVDEDGSSRRKNPNVLITGTPGTGKTTHAEMLAQESNGALRAINIGDFVKEHGCHEGWDDEWQSWLVDDEKLLDELEPLMSSSEGGIILDWHSSEIFPERWIDLVIVLRTSHTILWDRLEKRKYSLKKIQENNEAEIMGECLEEARENYDEEIVIELDSENIDAIDSNIHRILAWIEQWKTDNQDLSN