lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.
Subcellular Localization:
Cytoplasmic vesicle.
Sequence:
MRGALQAVALWGRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELKISAKELLFGHSASVTCLARARDFSKQPYVVSAAENGEMCMWNVSSGQCVEKTSLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLVLDAGTLAVLHTFTSLQSPDWMKCMCIVHSVRIQEDSLLVVSITGELKVWDLSSSINSIQEKQDVHEKESKFLDSFNCQTIRFCPYTERLLLVVFSKCWKIYDYCDFSLLWTEVSRDGQFFAGGEVLAAHRILVWTEDGHSYIYQLLNRWAQMGATLRTFSGLSKCVCPADGGVLKGTVYPHLLCSTSVEENKSLHFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPISKFDGSPREIPITTTWTLQDNFDKHQMVSQSITDHFSGSRDEVGMTATITSSEYIPNLDKLICGCEDGTIFITKALNAAKAGLLEGDSLLKDSPCHTLLRGHHQSVTSLLYPHNLASKLDQSWMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPENLKRSDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARIILNCGDDAQLIRSEPTLSVASETHKHKSIEQKSSNSHQPGPVPCPSVQLESSCKVADASSVPRPFNVLPVKTKWSHIGFHVLLFDLENLVELLLPTPLSDVDPSGSFYGGDILRRAKSTVEKKTLTIRRNKASCSSLQTEAQAKPSGDSLVLGDSTSKFSEENNGIKRQKKMKSSKKAHPKPPRKVDASLTIDMAKLFLSCILPWGVDKDLDSLCTRHLSILKLQGPVSLGLASNEDLFSLMLPGWDACSTEMKEYSGVNLCSRKVLDLSSKYTATLLHQTGIPRGLESHCDSVQQSDAIVYLLSRLFLVNKLVNMPLDLACEIDRPFKMETVHSKARFPGSDILNISSFYGHPKNGGNECRAPEADLSLLKLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLRNTPVSSQPDPVAEHSICERMQISAKMEWTEELELQYVGKSSPLKTSVSPVKHGNDLNSANFQDTEDILDRCVLEESESAGQPRHRPWIAKVCSCRMC
The following text describes a protein:
Function:
Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues.
Subcellular Localization:
Nucleus.
Domain:
The protein contains 2 transactivation domains (TAD). Each of these domains may be required for transcriptional activation of a subset of target genes.
Sequence:
MKPDRDSLDEFFEYEAEDFLVYLALLITEGRTPEHSVKGRTEGPHCPPAQLSQPAPNKHECSDKLAQCREARKTRSEVAFLWRNNIPIMVEVMLLPDCCYSDEGANTDGNDLNDPALKQDALLLERWTLEPVPRQSGDRFIEEKTLLLAVRSFVFFSQLSAWLSVSHGAVPRNILYRVSAADEELKLNFSHSPTEHVFPVPNVSHNVALKVSVQSLPRQSSYPVLNCSIHSNLGFYEKKILPREHSVTQPHNSQDNDQNSAPVSQHAFTKPSWSVGPEGLLHARTNVSTDLSLPVRNSKLLSTVDKGYSIGTPPSKHQCFSMTGNYKAAPQEPVRNFKSFSLVGVPCSPQASQTVETNPLIGSLIQERQEVIARIAQHLLQCDQTSSQINSHSIINELSSINGKIKNSSEDEKFQKKNKESPPICTSTLALTLSTGNQISNLKKAPDTPINSSRPILEFHTSPNPQARRKLILFESNEHFCNPFQSSGQSTVPSSNNENINKLPEKRDIKQSEHGEISTRTGNQLSNSCNTNDRLCTNTQIVPEDKSCTDSFHKPQKDNPKICSQKVGHRNGQAQETTCRETRKSDHSNQLLSIENCINKDRDNIQYKEPQDKLKSVHDENEDPTNCDCLAQGQRKCNGNCLQRSESLKNTEQKPIQLRHSCTWKKQTFRSLDGISTKAFHPRTGLPLLSSPVPQRKTQSGYFDLDNSLLKLKGLSTQRQHVNGFTDEDTVATNKQLSSSAPPAPCLSLLGNFEESVLNYRFEPLGVVEGFTAEVGASGIFCPTHMTLPVKVSFYSVSDDNAPSPYMGNITLESLGKRGYRIPPSGTIQVTLFNPNKTVVKMFVVKYDLRDMPANHQTFLRQRTFSVPVRRETKGAVTENGLKAEDRTLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKSYIETPTNPQYSPRC
The following text describes a protein:
Function:
Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis. Has no activity with either L-ornithine or L-aspartate as substrate. Also has no detectable AOTCase activity, being unable to convert N(2)-acetyl-L-ornithine to N(2)-acetyl-L-citrulline.
Sequence:
MKKFTCVQDIGDLKSALAEAFEIQKDRFKYVELGRNKTLMMIFFNSSLRTRLSTQKAALNLGMNVMVLDINQGAWKLETERGVIMDGDKPEHLLEAIPVMGCYCDIIGVRSFARFEDRDFDYQETILNQFIQYSGRPVFSMEAATRHPLQSFADLITIEEYKKTARPKVVMTWAPHPRPLPQAVPNSFAEWMNATDYDFVITHPEGYELAPQFVGNAKVEYDQMKAFEGADFIYAKNWAAYTGDNYGQILSKDREWTVSDRQMAVTNNAFFMHCLPVRRNMIVTDDVIESPQSIVIPEAANREISATVVLKRLIEGLE
The following text describes a protein:
Function:
Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MALYSISKPVGSKINKHSYQDENTLVGKQALSKGTEKTKLSTNFEINLPRRTVLSDVSNVGKNNADEKDTKKAKRSFDESNLSTNEEADKPVESKFVKKLKVYSKNADPSVETLQKDRVSNVDDHLSSNPLMAEEYAPEIFEYIRKLDLKCLPNPKYMDQQKELTWKMREILNEWLVEIHSNFCLMPETLYLAVNIIDRFLSRRSCSLSKFQLTGITALLIASKYEEVMCPSIQNFVYMTDGAFTVEDVCVAERYMLNVLNFDLSYPSPLNFLRKISQAEGYDAQTRTLGKYLTEIYLFDHDLLRYPMSKIAAAAMYLSRRLLRRGPWTPKLVESSGGYEEHELKEIAYIMLHYHNKPLEHKAFFQKYSSKRFLKASIFVHQLVRQRYSVNRTDDDDLQSEPSSSLTNDGH
The following text describes a protein:
Function:
Involved in excretory canal elongation during postembryonic development. Plays a role in promoting Golgi stability, ER integrity and vesicle transport probably by regulating the activation of Rho GTPase cdc-42. Involved in fertility.
Subcellular Localization:
Cytoplasm. Apical cell membrane; Peripheral membrane protein. Note=Co-localizes with gck-1 at the apical membrane of the excretory canals.
Sequence:
MNEEGGYLGAMTYQCLYSPVMEKIKQQHRDDPRASLALNKLHTALTTCEQASPSFLYDFTKVLLDDSELSVNLQESYLRMHDTSPTNDLIVSGYEQNADYKELTKRAIELRRVLSRVPEEMSDRHAFLETIKLIASSIKKLLEAINAVYRIVPLTAQPAVEKRKREFVHYSKRFSNTLKTYFKDQNANQVSVSANQLVFQTTMIVRTINEKLRRG
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Sequence:
MSQQNRRVQQNTAAFPLLTAHDILECLAALDIPAQMEDLTKPTAQSTQSIYGSLLEVLMGASINSIEGPKQALLGMMEYKEMYSDTLQFMMFFKHCRRLALLCGIPDFAISDLARPDANRLRKVLSGIMNFAKFRDERMQTQARFQENLQKHQKKAVDLRRKTEELETQFQEITARNAAERPQSEQAQKRNELLKSELLELNSQRLKEVQEYEELKKERQTLLEQVNHNNRIVTQLELQIGSAKSRLVQSPDRIKRHISEMSFAIQSEKAKLASFQQKARELTNRLEVIGALEVDLRGLIDLEHSIQDQRAKTEEAKRSKSALEARLEGRQIESQGLAAKLEQLQRQLQNASHKLARQEETRKGMRERGARRIDELKAEYKVRARERGEWQKQRDDLLAEQKELESEMAAFVTKHENEINEFLHAYWTMRRQAEDYMNTMTVKLGLQVQL
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNMILKLSLKDIVFINPLVKYLNIFFITPWYDFPTNQKYYPSLAKCYACLLMVVKILWVIYWLQDDALKSVYASLLCTEKIFLFAIYTNLSILTTVTIFKSAFWDVDKWRTLFTNLQYIDINLQNKGKKESKLMKNFYFWFVLKQVMFLCYSTYGIQVFGTMQRTSFFKTFLNSCLMDVYYEFLLISLINILIRSFKSRYKDLNQKLETACEQSKSVEELMNIANYYRILGDTVEIFNSLFGYQIILVIFDCCLETVSALNGAFLYTINGQGQFNIEMFLCNMSLLTVIPYFIAMIVLSTDSTTQEAKKFTYLCWKYQENFTQGSKELEALEKIASSSAEYFRGFHAAGFFNVSKNLVFSLISNIATYFIITIQLNSSESNQ
The following text describes a protein:
Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular Localization:
Cytoplasm.
Sequence:
MVMDDLFQRMVSCVLPSWRAFIDEEVKKPYFQALLEKLKALKATIIPKPELIFRVFSFFKPIDTKVIIFGQDPYPSPNDACGLAFASNNSKTPASLKRIILRLEKEYPSLKQESSWQQNFLLNWAEQGVLLLNGILTTTVFIRNAHKNWGWEEFNCNLLTFLKNQNIKPLLVFLGVQTKNFVVKSIGNVDGFEHLSYPHPSPLSGNLFLTNPNDLFKTINNWLKQHNQKIINWAVVKNASFDQLS
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system.
Sequence:
MFKRGGIYSVNLAQEGDGTPETCPCVVVSNNISNEFSPVVTIIPLSFRNLEKIYEFETFLPATKTGLAADSKLSSHIIITIDKAKVVGERLGFLSKTLMEQVEKALRFQLEL
The following text describes a protein:
Function:
Has antifungal activity against C.albicans. Has antibacterial activity against the Gram-positive bacterium S.aureus and the Gram-negative bacterium E.coli. Lacks hemolytic activity against rabbit erythrocytes.
Sequence:
MASGWTHRLLLLAAVVTLGATPIAAASMEYLVTAPGYLTPNADIKITAVVTNPSSAGQLKVDLWGTRSGIQPEQHSSGKSDVRRWRSRY
The following text describes a protein:
Function:
Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination.
Subcellular Localization:
Nucleus.
Sequence:
MNTEQSAEPHYSNSKCLISTPEGKDLKNGAVKRTPSSKFKRVHSNFKSPLQVPESAKVSPAEEVAELEGRREQLDAEIAQLEVEGCRVEELEHHIDMLHEYNDIKDIGQSLLGRIAAVRGTTTRDLYSHFGLELDD
The following text describes a protein:
Function:
Possesses antifungal activity against C.albicans and is also active against E.coli and S.aureus.
Subcellular Localization:
Secreted.
Sequence:
GINTLKKVIQGLHEVIKLVSNHE
The following text describes a protein:
Function:
Forms the collar, into which the side tail fiber protein pb1 is anchored.
Subcellular Localization:
Virion. Note=Component of the tail. Assembles as a dodecamer surrounding the baseplate tube protein p140 trimer.
Sequence:
MSTENRVIDLVVDENVPYGLLMQFMDVDDSVYPSTSKPVDLTDFSLRGSIKSSLEDGAETVASFTTAIVDAAQGVASISLPVSAVTTIASKASKERDRYNPRQRLAGYYDVIITRTAVGSAASSFRIMEGKVYISDGVTQ
The following text describes a protein:
Function:
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1 constitutes the catalytic core. Plays an important role during male gametogenesis and embryogenesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MITIPYLTAVSTYFSYGLLFAFGQLRDYSRLIFDWWRTNNLQGYAPICLAHEDFYIRRLYHRIQDCFGRPISSAPDAWIDVVERVSDDNNKTLKRTTKTSRCLNLGSYNYLGFGSFDEYCTPRVIESLKKFSASTCSSRVDAGTTSVHAELEDCVAKYVGQPAAVIFGMGYATNSAIIPVLIGKGGLIISDSLNHTSIVNGARGSGATIRVFQHNTPGHLEKVLKEQIAEGQPRTHRPWKKIIVVVEGIYSMEGEICHLPEIVSICKKYKAYVYLDEAHSIGAIGKTGRGVCELLGVDTSDVDIMMGTFTKSFGSCGGYIAGSKDLIQYLKHQCPAHLYATSISTPSATQIISAIKVILGEDGSNRGAQKLARIRENSNFFRAELQKMGFEVLGDNDSPVMPIMLYNPAKIPAFSRECLRENLAVVVVGFPATPLLLARARICISASHSREDLIKALQVISKAGDLTGIKYFPAAPKKQEVEKNGIKLD
The following text describes a protein:
Function:
GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity (By similarity).
Sequence:
MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHHGHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDCLLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVAVDFVLSQLKGESA
The following text describes a protein:
Function:
Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed. By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle. Endosome membrane. Golgi apparatus, trans-Golgi network membrane.
Sequence:
MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENIILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNKGRPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYIKLILPELGPVFKQQEPIQASNMILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHIMQEQQRSLDIGNQMSTSEETKVTPSGTQQIDKVFNNIGADLLSGGESENREDGLQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPIAPVKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTSVPSTGLSMMFSTPIDNTKRNLTNGLNANMGFQTSGFNMPVNPNQNFFSGTSTAGVTTMTLGAPPTMSNFSPLSIPPASVKQTQQRPPDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFVPPQGSPGMGSAAMGTQVNVMGQAAFGMQGNPFFNPQSFAQPPPTTMTSSSSASNDLKDLFG
The following text describes a protein:
Function:
Involved in cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction.
Domain:
The cytoplasmic region mediates interaction with EPB41L1, DLG3, PALS2 and CASK.
Sequence:
MGAPSALPLLLLLACSWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVSSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKETATLNCQSSGSKPAAQLTWRKGDQELHGDQTRIQEDPNGKTFTVSSSVSFQVTREDDGANIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPEPAHPREGQKLLLHCEGRGNPVPQQYVWVKEGSEPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYTAYFTLNVNDPSPVPSSSSTYHAIIGGIVAFIVFLLLILLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI
The following text describes a protein:
Function:
Directly involved in telomere replication. Associates with telomerase and during its interaction with CDC13, telomerase activity is promoted.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MDNEEVNEECMRLFFKNARAHLDKHLTSRLTCDENAYITFRCFLDGIHRKSTRFLEELLLKQENMYHNNNYERINDSVIPLVLKLLWLQIHEPTLQWFEHWFHDIMRLSNRRKFRVFRIFQKKMIQFFKITHRYYYDIIEHLCAKYDMNSVISNALFAKLNLMQYTDGLSTHEKIILNTSNPLTFSIVISLQRCVINLGSTHFYKTLLNKPSNKPKSVEGFEKSIRYLNIASLYLPAVGDTYFQRAKIYLITGKFSLYFFELVRGALVRIPSKCALNNLKDFILTPDFPERRRLMKKLAILVSKDLKGEKSFFEGQIVLQFLSIVEHTLVPQSWNASRASNCWLLKEHLQMAALKYHSGNINVILENLAATMGSFDLMFTTRKSKEQKNKLKYADLSERQVFFLDLSFDFIANIIDVVIKPSWQKNMEDFRYLAIIRLLMCWIKSYRSILQYTHRHRKFCTSFALLLNDLINSPLNCSGNIYSHRPKRSYLFREDIIFREFSCINFALTDFNDDYVYDSPDMINNIIGCPTLTKVLSPKEECVLRIRSIIFSGMKFLEKNDTGVIWNASKYKFDLISPNIKIKRQIALSEISSKINVKTQQERVVSSRKVEAKRDEQQRKRAGKIAVTELEKQFANVRRTKKLSPLPEKDGVSSELVKHAASRGRKTITGPLSSDFLSYPDEAIDADEDITVQVPDTPT
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MRMQQEEKLIETSLEAITSRVQEVRDSVHTFLAKLEREPLNWPSVLDNFALLSVPDHLRTKYEPEVEEAEQSLVVASASITQENAQKQINHLNELLTTLTDMITSAKEDWEGEQNSVPDHLRTKYEPEVEEAEQSLVVASASITQENAQKQINHLNELLTTLTDIITSAKEDWEGEQNSASRSTSSTNPDIGALVAAVTFGKGLKPNKTTNSSKTRTSTSSEQGSAQWMNNKADQPGKHPSSIKTELKAAASPHPYAGRPPNRS
The following text describes a protein:
Function:
Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.
Sequence:
MNLCIVGCGGIGCEVAKLVVQAPARYASVAVIDMDSIELSNINRQFLYSRDDVGREKAHVTADYLRAKAPSLRVNSYSETVINPKRFGPSFFSQYDVTVTCLDAFAPRQYVGEMCWFANKLLVDAGTSGLSGSVTGYPPALYWLSEDPTVECYNCYNRDTRIDIPICTMKNKPTRPEHCVSYSILLVQRMYDVDPFSELTEYTPIDCSGSIDKLLSELARFLYYSFKTHLLDNPSASAVLDMEDINKARQAVTHLLAASEHEDGAIQPCIKQTSLSVSYTLHEHMSVEQALKEVFISATALARSIACKAYTLTTYDRDNPHLVALVAGLSVLRMHSFGITTTLTPFELSTLAGSIVPAVTFTNAAVAALAMKLAHMIFSSLITKQHRTAISLQHFIKNSRRTLLINDDLRPSNPACVVCSVPYYILKVKDVPPLSVDAVIEYLTKEFSSTISAIYGDGVLLYEDDTPSGWTDDSSTPGTNDETEHVQNTLQSASQIYDGEILKIKYSSHTQKQLSMNVMVRTDNTLEVAYLFTAGRA
The following text describes a protein:
Function:
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (By similarity); Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Subcellular Localization:
Postsynaptic cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, dendrite. Postsynaptic density. Note=Cytoplasmic face of glycinergic postsynaptic membranes. Forms clusters at synapses (By similarity).
Sequence:
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEKFPTFPFCGLQKGATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKQIRRPDESKGVASRVGSLKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
The following text describes a protein:
Function:
3'-5' DNA helicase that may play a role in the repair of DNA.
Subcellular Localization:
Nucleus.
Sequence:
MKDQDLELEKVRLISLATKLGFDEDSAKKCLDRFVDLYGDDGRDFITVELCGDDFLAALADFEEGTEEWDDIQAIESEAQGNLAEMFDKSTNPSDNGFDTDDDDDDSRVEVHVIEDSPEPKKKPEIVELDSSSDLEDVETRFKVPRRSQTCSRSMDYSMEDSVSTISGRKPSVQISNKDHETPSYEELQALDDLEFANLVIFGNKVFRPLQHQACRASMERKDCFVLMPTGGGKSLCYQLPATLKAGVTIVISPLLSLIQDQIVALNLKFGIPATFLNSQQTSSQAAAVLQELRRDNPSCKLLYVTPEKIAGSSSFLETLRCLDRKGLLAGFVVDEAHCVSQWGHDFRPDYRELGCLKQNFPRVPVMALTATATESVCQDVLKSLRIPRAPVLKMSFDRINLKYEVIVKTKEPLKQLQELLRDRFKDQSGIVYCLSKSECVDVAKFLNEKCKVKTVYYHAGVPAKQRVDVQRKWQTGEVRIVCATIAFGMGIDKADVRFVIHNTLSKAVESYYQESGRAGRDGLQAQCICLYQKKDFSRVVCMLRNGQGRNMDRFKSAMAQAKKMQQYCELKTECRRQMLLEYFGESFDRMICKSSLNPCDNCERS
The following text describes a protein:
Function:
Has guanylyl cyclase on binding to the beta-1 subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPRPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQERFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTNITKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKSKHVTEGHLTQLSVAGFNSLEVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPLQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL
The following text describes a protein:
Function:
Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Functions redundantly with ksr-2 in the Ras-mediated regulation of larval survival, the development of excretory canal and in mpk-1 phosphorylation in somatic cells. In addition, involved in determining vulval precursor cell fate during vulval induction independently of its kinase activity. Plays a role in egg-laying.
Sequence:
MMQTQVASRAGYSNLPQFGAGIAQDIKTQAINNLKECLKLTTINRFLTSSYEEDAKSVERKIFSAVYQMTKIGLIDREKREINAIWFTFVGLSAQNIRHLEICSITDFNALFSITNQELRSLADRGRLDVETKRKLLQSTVILQNHWNAYHSRTSSGSTDEPSGQSTPAIVTPSPKFNVPSLSVTSAKMIQSSSMGFATTPKSPKTSSRLVHAIPHKWHRSTKFRFSGDAVCHFCQRPLGFGFLNAWEKCRSCKWKVHTQCKGRVGDSCGLTPDHLRFLFDKLIQENNGGMWKDPQSVPGSRSMNEPAFQFPDTAIDSSSSTNSSAPSTPALPAGISGNVSSLTAPYRSERKFLFPDTENYSVHNRLPILVISEGDHPTTTEIQQETENHNKSAAASMSGNIESEGTIVANHEDSTGSQEVDSEAAPSQEAVDKFNKRADGGFTWERHAWNMSTIRGPNAQASWNEVTIQFETIEFDKQAPIIGRGRFGKVLRGFHYGDVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSKGSQSLYTLLHVVREKLDLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHPKQKSGYLTSKFWTNYIAPELAMAMRTEYDEYECDDFPFSENSDVYAFGCVWFEMLTGALPYAGELPHQILFAKTQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKLTALPKKPRVNRSPSFPVMMKSYESTF
The following text describes a protein:
Function:
Xylan acetyltransferase required for 2-O- and 3-O-monoacetylation of xylosyl residues in xylan. Catalyzes the 2-O-acetylation of xylan, followed by nonenzymatic acetyl migration to the O-3 position, resulting in products that are monoacetylated at both O-2 and O-3 positions (By similarity).
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKKKKNGMGAAADRGRLLALAHHDKLNPTKPSEAQRRFKPSILLLLGSSLPRLVPPLPSSFLPVVIKQTEFHQRWLVGDLNPPPPPCHLLPIQGQGQMQMQQRRKPPPAAAPVAAKQPSPRRTPGPLSFAGALLSLLVVATFLYINDHGNMMPPHASPDPDLRLLQEAAHQKVNSILLSRHAPAPPPRTNTNTSSSDQHLRLINIPMSSDLDLELGGNSTSSSGVEIQFEQQQQQEEKNLRGCELYKGRWVYDAAGREAPLYRESECGFLTEQVTCMRNGRRDDSYQRWRWQPEGCDLPSFDARALLERLRNKRMMFVGDSLNRNQWESMVCLVQSAIPYGQKTLTKFVNNGSLNVFRAHEYNATVEFYWAPFLVQSNSDDPQVHSVRDRVIAWRSIAKHAANWKGVHYLVFNTYIWWLNNFQIKVLKSRGAPFAGSGGWSSRYALVDRAIAYREVLKTWAKWVDRRIDPNKTHVFFMAMSPNHFMPEAWGGSAGAVKCAMETQPIVNRTSGGLDIGTDWRLHGVARGVLRSMRRVGVRFVDITALSELRKDAHTSVHTLRQGKLLTPEQQADPRTYADCIHWCLPGLPDTWNHFLYAHIVAHAA
The following text describes a protein:
Function:
Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. SSZ1 is required for ZUO1 to function efficiently as a J-protein for SSB1/SSB2. Also involved in pleiotropic drug resistance by post-translational activation of transcription factor PDR1.
Miscellaneous:
MISCELLANEOUS: Present with 73600 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm.
Domain:
Neither ATP binding nor ATP hydrolysis is required for SSZ1 function; Does not seem to bind unfolded protein substrates, as its C-terminal putative peptide-binding domain is not required for its function.
Sequence:
MSSPVIGITFGNTSSSIAYINPKNDVDVIANPDGERAIPSALSYVGEDEYHGGQALQQLIRNPKNTIINFRDFIGLPFDKCDVSKCANGAPAVEVDGKVGFVISRGEGKEEKLTVDEVVSRHLNRLKLAAEDYIGSAVKEAVLTVPTNFSEEQKTALKASAAKIGLQIVQFINEPSAALLAHAEQFPFEKDVNVVVADFGGIRSDAAVIAVRNGIFTILATAHDLSLGGDNLDTELVEYFASEFQKKYQANPRKNARSLAKLKANSSITKKTLSNATSATISIDSLADGFDYHASINRMRYELVANKVFAQFSSFVDSVIAKAELDPLDIDAVLLTGGVSFTPKLTTNLEYTLPESVEILGPQNKNASNNPNELAASGAALQARLISDYDADELAEALQPVIVNTPHLKKPIGLIGAKGEFHPVLLAETSFPVQKKLTLKQAKGDFLIGVYEGDHHIEEKTLEPIPKEENAEEDDESEWSDDEPEVVREKLYTLGTKLMELGIKNANGVEIIFNINKDGALRVTARDLKTGNAVKGEL
The following text describes a protein:
Function:
Involved in the biosynthesis of the riboflavin analog antibiotic roseoflavin (3,8-dimethylamino-riboflavin). Catalyzes the site-specific substitution of the C-8 methyl group of riboflavin-5'-phosphate (FMN) by an amino group to yield 8-amino-8-demethylriboflavin 5'-phosphate, via a combined oxidation, decarboxylation and transamination reaction. The catalysis is initiated by an oxidation step in which the C-8 methyl group on the dimethylbenzene ring of FMN is converted to a formyl group to yield the 8-demethyl-8-formylriboflavin-5'-phosphate (OHC-RP) intermediate. In the presence of thiamine, the formyl group is oxidized into a carboxyl group to yield the 8-demethyl-8-carboxyriboflavin-5'-phosphate (HO2C-RP) intermediate. Finally, in the presence of L-glutamate as an amino donor, decarboxylation and aminotransfer occur, resulting in production of 8-demethyl-8-aminoriboflavin-5'-phosphate. Addition of NAD (but not NADP) to the reaction increases the yield 1.7-fold. The reaction also proceeds without the addition of any electron acceptor, and it is possible that molecular oxygen serves this role.
Sequence:
MALKALILNTTLRRSPSRSQTQGLIDKAVPLYEKEGIETEVVRVIDHDIEQEYWDDYDDWNAGEKARREDEWPWLLEKIREADILVIATPITLNMCTSAAHVILEKLNLMDELNGDTKQFPLYNKVAGLLMCGNEDGAHHVAGTVLNNLGRLGYSVPPNAAAYWLGPAGTGPGYIEGKGDRHFHTNKLIRFMVANTSHLARMLQETPYTTDLEACAQAAREESDDVFAIRVNVNTPAIRYKRFQKLGEVKVEESQLG