lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
Subcellular Localization:
Cytoplasm. Nucleus. Nucleus speckle. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
Domain:
Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID) (By similarity).
Sequence:
MEGSVVVSEKKRISSERRKEKSRDAARCRRSNESEVFYELSHELPLPHNVSSHLDKASIMRLDHQLPAVEKVADAGDLDGETELDKQLNCFYLKALEGFVLVLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRNGPAKKRKRTNHREKFLPSYEMYINQSWKNREYKVSHMEGPSLYRTHACIYDNANNQNHCGYKKPPMTCMVVICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELVGYEPDELLGRSVYEYYHALDSDHLTKPNYNMFTKGQVTTGQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTASVLIPVESQEIKMPEIFTELNEENNSECLFDKLKQEPESLTVLAPDAGDEIIPLDFSSGDSDKPYEDVPLYNDVMLHSTSNKLESTPITPLPAPEMPKPLRSNVDPALNREVVIKMESNPRTTCASIHHSTAIQARQPFRYQFQSEPSTEPNTPEYCFDVDSEMASEFKLDLVEKLFAIDTEAKAPFYYPGNDLDLEMLAPYIPMDDDFQLRTFDQLSSLECDSSIPQTLGSMTTLFHQSLSPSTSDFKPEDAMSDLKTIIQSPVHMMKESTSAPVSPYNGNRSRTSSPVRPAKAVVDKTEKSRPGTPNLPVPLNKRCTILDEELNPKMICFTQCTAEKRKMESDGPLFQAIGIGTLFQTNVDPGPNSSLQWKRVKGSDSERLSSAEQRTILLLSTDMASQLLGQSFDGTVLPQLTGYDCEVNAPVHGTRNLLQGEELLRALDQAN
The following text describes a protein:
Function:
Component of the replisome and is required for rad3-dependent activation of the checkpoint kinase cds1 in response to replication fork arrest. Phosphorylation allows it to mediate the activation of cds1.
Subcellular Localization:
Nucleus. Note=Associated with chromatin.
Sequence:
MASLDENADELHRMDSSDEASINDDQEDILDTPRTRVRKMLASVDMQLSSNAVSEASLDKESTVGNLENQKNRSYSSEIYLHSDTNFLSNFDSAYERVRRLLNQQGGKSSLQKKEVEQIETQEGGDNAKGSPSSENKDSDRNSRLQQLIEKKRNALKKEQEDLIQNSATSHSKSDNLDSESADDSDLADESELSKKYTSDRKIRNASKKALLELHRNTARLTRETALKPEVVVKKKVTLREFFQKIGFKNDNQLENKAISEEEANSTEPPNVEKEEPKPSVDRSTGIVNSEDIKELSVEDDSLELKEITPEALDIGQTSLFTTLNQTQVKKEDNKKFLLKEINAKLNEDDIDSELEIEVKPKTTALDNIEKSKLSEENEHGIKGKLKQLAEIKLSKDGKPFENEFNIKSFNRNLVKRAAVMAKLQRNQLEEELKAKGIYKPTIQGEKEEEEDPLERARNDAEKIRQLEKASGNASDEGELNDEEEVISSSNTPSTKAKTTNKVIISDVIIEATQAEPKRRQKNSRVVFDEEDLTGDSHGSSNMKISESDDESNGDMIRDSFDRLSSESIKDSQKTEELHDSFGINDEVDQSTSLYVQNSQPSASQLTIVDATYSQPPPRWESSSRDDKTNTSSTQPSQVDSLVPTQLDSTIPTQIDSVQRNKDQDDEEILEERRESRRDSKTFLSRTMLYNKDTGKADSAWASDLIEEQAIESDDEYAGIGGLSDDGLSDSDAELEVQNMIDDETTIQKGEVASMAQFAKDQEMDRDEKLVKQLMKDVTTGALRKRNRNGFAALDDSDDEDYSNLRREKLKELRRQKLLEDGNLNVLEGDKRKAFLATVEDSLVSSKDNLTWLDATVEDSGVGSSDLGDEYLYSEQSLNHEEEEQMEEELSEIFSSGGPNVVDRVYLKKSSTRHTSDNNSLEEVLPIFPGVRKLVSNSQSEKIGDLSNDNSMGAKSYKTPIISSTQRPQGRKFRGLMNQSSKADISRTVDAGSIKVVPNSQSANPPRLLASLNNYSDFD
The following text describes a protein:
Function:
Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Plays a role in maintaining gonad integrity in a daf-16/FOXO-dependent manner. Required for the response to environmental stimuli such as light, food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. In a daf-16/FOXO-dependent manner, plays a role in regulating the response to white light. Role in immune function and pathogen resistance. Negatively regulates autophagy. Regulates daf-18/PTEN protein levels. Plays a role in controlling seam cell development during the larval stages; [Isoform a]: Required for taste avoidance learning in the cell body of ASER gustatory neurons; [Isoform c]: Required for taste avoidance learning in axons of ASER gustatory neurons.
Subcellular Localization:
Membrane; Single-pass type I membrane protein; [Isoform c]: Cell projection, axon. Note=Localizes to the synapse-rich neurite that extends axons. Casy-1 is required for axonal localization.
Sequence:
MTRMNIVRCRRRHKILENLEEENLGPSCSSTTSTTAATEALGTTTEDMRLKQQRSSSRATEHDIVDGNHHDDEHITMRRLRLVKNSRTRRRTTPDSSMDCYEENPPSQKTSINYSWISKKSSMTSLMLLLLFAFVQPCASIVEKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQSCWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKTVPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIVCEINHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKSLFRNLYAITVFENPNLKKLFDSTTDLTLDRGTVSIANNKMLCFKYIKQLMSKLNIPLDPIDQSEGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDIDQRKFLGYELFFKEVPRIDENMTIEEDRSACVDSWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNGVSKIGFVRTSYYTPDPPTLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLLTMMGHEDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPAPTIASMYALTRKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSACQNMTVPGASCSISHRAGALKRTKHITDIDKVLNETIEWRFMNNSQQVNVTWDPPTEVNGGIFGYVVKLKSKVDGSIVMTRCVGAKRGYSTRNQGVLFQNLADGRYFVSVTATSVHGAGPEAESSDPIVVMTPGFFTVEIILGMLLVFLILMSIAGCIIYYYIQVRYGKKVKALSDFMQLNPEYCVDNKYNADDWELRQDDVVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSFVLTDNQMILDDSEALDLDDIDDTDMNDQVVEVAPDVENVEVQSDSERRNTDSIPLKQFKTIPPINATTSHSTISIDETPMKAKQREGSLDEEYALMNHSGGPSDAEVRTYAGDGDYVERDVRENDVPTRRNTGASTSSYTGGGPYCLTNRGGSNERGAGFGEAVRLTDGVGSGHLNDDDYVEKEISSMDTRRSTGASSSSYGVPQTNWSGNRGATYYTSKAQQAATAAAAAAAALQQQQNGGRGDRLTQLPGTGHLQSTRGGQDGDYIETEPKNYRNNGSPSRNGNSRDIFNGRSAFGENEHLIEDNEHHPLV
The following text describes a protein:
Function:
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MLDESKFDLQLKLWALRIPREWCKVATKLLNGHMLDRPRIKPITEDPNSEKTRYVILSEKVQNPDLSDIPTQKLNELEKLCKIETVPYTLTLGYSYWGADHVLKQVLPPGLEVPSSFETIRISSHIAHLNIPDELLPYKDVIAKVIYDKNHPRIQTVVNKVGSIANEFRVPKFEILAGKPDMATEVKQYGATFKLDYGLVYWNSRLEHEHIRLVNKFDQGDIICDMFAGIGPFAIPAAQKGCFVYANDLNPDSVRYLKINADVNKANNNIRAYNMDARVFMSRLMTVPDGESEVVDSSLVSSGTCNVQENMKANTEEKNSENGSLKCVDAHVAVKTKGSKNKRIKTSVSFTNKSWEHIDHVIMNLPASALQFLDVFRGLIQRKYWKGSLPWIHCYCFIRSNETQDSVVSEAESLLNAKINEPVFHRVRDVAPNKAMYCLTFRLPEEACINEEITNS
The following text describes a protein:
Function:
Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.
Subcellular Localization:
Mitochondrion intermembrane space. Mitochondrion matrix.
Sequence:
MDDQTRFLKDYDCESQWFKHSRTGADWIHLKKSDTNNVFMVGFQTDVTDSTGVPHILEHTTLCGSKRYPARDGLSIHPLNRLYCESNTIVKCDDLTVYPFSTENKTDYYNLMNVYMDAVFAPRLRRLDFMQEGWRLEHENPRDSSTPIIFKGVVYNEMKGALADTNSLFHTRHQQALYRDSTYAHVSGGDPENITDLTHEQLLQFHAKNYHPSNARFFTYGSFPLEEQMQKVDEKLSGFSSSSRHSLEDVPRWNEPKTIQAVGPLDPMGDPLKQSRVAVSYLTNSEKNLEESLSMRILVNLLTDGAASPMYTSLIESGLGSDYAPTTGHSQFACRASTSFGLTGMESKNIPVAIESIQYVLEKAAQTGFPENRINNIFHQIELGLKHRTASFGMNLGWNIIRTMIHGGNPLDAMDTAPSLAKLKSDLSQPGFLQNLVETQLLSNPHRLTYIMNPDAGYPASLIEKESQRLAKHVDALTDSDRENIKSDGLELLKLQETKEDLSCLPCLSLSAVKKQASFYPLKITQSANGIKQFWRETQTNGVSYVYLKWDVTYLSDREKLLAPLMCNSLTSLGTHSKSLGELDETIRAHTAGISASVFSSPSIDGDSPRDYLVLNASALDSNIDAMYNLVLEVLQTTNWAAYDNLNIALMSSAAGAANSVPNSGHAYAIKAAAGLLKRTCYSSELFGGMHQVEFLDQLLKQTEIPALAKELETLAKKMIQTSPLEVLVVSGSQSVDRHSHIHDQSFSCFAQSKPSTFSNSSDIVDFVPKYEMRNYPMDLGVNFTARSVSTVSYVHPDAASLKVLASLMSTHYMHRELREKGGAYGGGASYNTLDGVLSFMSYRDPPGAKRTLDAYERSVAWACEITKHVGNEELDQAKLEAFRNMDKPVDAAGEGLTQFQYGLDLFALQAHRDALFKVTMQDVERVAKIYLQRPCAMSVIGEKVSA
The following text describes a protein:
Function:
May be involved in pectin and/or xylans biosynthesis in cell walls.
Miscellaneous:
MISCELLANEOUS: Expression not detected in roots, inflorescences, siliques, leaves or stems. The signal-anchor present in all the other members of the family is missing.
Sequence:
MTDACCLKGNEDKMVPRFGHGTWIGKAFNDTPEMLHERSLRQEKRLERANELMNDDSLQKLETAAMARSRSVDSAPLGNYTIWKNEYRRGKSFEDMLRLMQDQIIMARVYSGLAKFTNNLALHQEIETQLMKLAWEEESTDIDQEQRVLDSIRDMGQILARAHEQLYECKLVTNKLRAMLQTVEDELENEQTYITFLTQLASKALPDAIHCLTMRLNLEYHLLPLPMRNFPRRENLENPKLYHYALFSDNVLAASVVVNSTVMNAQDPSRHVFHLVTDKLNFGAMSMWFLLNPPGEATIHVQRFEDFTWLNSSYSPVLSQLESAAMKKFYFKTARSESVESGSENLKYRYPKYMSMLNHLRFYIPRIFPKLEKILFVDDDVVVQKDLTPLWSIDLKGKVNENFDPKFCGWAYGMNIFDLKEWKKNNITETYHFWQNLNENRTLWKLGTLPPGLITFYNLTQPLQRKWHLLGLGYDKGIDVKKIERSAVIHYNGHMKPWTEMGISKYQPYWTKYTNFDHPYIFTCRLFE
The following text describes a protein:
Function:
Polymerase alpha in a complex with DNA primase is a replicative polymerase.
Subcellular Localization:
Nucleus.
Sequence:
MMGKQRPSSLFKKPGSNRTKGSSLAADSIVDDVIAEFAPDENDREERRRRVGRFSAPAPPPVPVAQIKAIQAAVDAEMEVRSDHGFEPDAVSDHVNDTEVELQPEVELKPDVEMQPKLEAAAGSSADLMDENKSSEELKQEANGEVKVEKVRRLNAKIKAEGTRNGDMLSATAGWMKICGDGENAGVEGEVAVHDIDDVDESSEFELKDGALPFYLLDAYEEPFGINSGTVYLFGKVVIGKRFHSCCVVVKNMQRCIYAIPSSSVFPRDTISRIEKNSTSSDASPSLRATLHELSSGLKSEIADKFSDLNVSNFVMTPVKRNYAFERTDVPIGEQYVLKINYPYKNPAVPADLRGEHFHALLGTNNSALELFLIKRKIKGPSWLSISKFLACPSTQRVSWCKFEVTVDSPKDISVLMASTTLEVPPVVVAAVNLKTIINEKHNVHEIVSASVICCHQVKIDTPMRSEDWQKRGTMSHFTVMRKLEGSIFPIGLTKEASDRNQKAGSNVLALESSERALLNRLMIELSKLDCDVLVGHNISGFDLDVLLHRAQTCKVPSSMWSKIGRLRRSVMPRLTKGNTLYGSGASPGIMSCIAGRLLCDTYLCSRDLLREVNYSLTQLAETQLKKDRREVSPHDIPPMFQSSETLLKLVEYGETEACLSLELMFHLSVLPLTRQLTNISGNLWGKTLQGARAQRVEYLLLHSFHSKKFIVPDKFAARSKELNSAKRKLNADTEGGNVADPTIDDEVHNGDQGKARKGSSYAGGLVLEPKKGLYDKYIILLDFNSLYPSIIQLLKSLVERRRMVKSWLKTASGLKRQQFDIQQQALKLTANSMYGCLGFSSSRFFAKPLAELITLQGREILQNTVDLVQNNLNLEVIYGDTDSIMIYTGLDGISKAKAIAGKVIQEVNKKYRCLEIDLDGVYKRMLLLKKKKYAAIKVALDGSLLENIERKGLDMVRRDWSLLSKEIGDFCLNQILSGGTCDDVVESIHNSLVQLEKYIITKSLTKAPEDYPDAKNQPHVQIALRLKQNGFSGCSVGDTVPYIICSQQDSDNTHSGGVAQRARHPDELTRDPNKWMIDIEYYLSQQIHPVVSRLCASIEGTSPARLAECLGLDSSKFQSRSTGSSNKDMSSMLLSVTDDEEERYRGCEPICLSCPSCTSTFECPPVSSLISSLSDTNEGKDATVNFWRRIRCPRCPNDTDECRVSPAVLANQIKRQADNFINQYYKGLLCDDEGCKYSTHIVNLRVMGDSERGTICPNYPQCNGRLARQYTEADLYRQLSYFCYVLDATRCLDKLDHKMRLPFEKEFAVLNQTISSAFLEIQKIRDRCAFGWVQLTDLAVSI
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MKLIVSVMPRSLEEAQALDATRYLDADIIEWRADYLPKEAILQVAPAIFEKFAGRELVFTLRTRSEGGEIDLSPEEYIHLIKEVAQLYQPDYIDFEYYSYKDVFEEMLDFPNLVLSYHNFQETPENMMEILSELTILNPKLVKVAVMAHTEQDVLDLMNYTRGFKTLNPEQEYVTISMGKVGKVSRITADVTGSSWSFASLDEVSAPGQISLASMKKIREILDEA
The following text describes a protein:
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MDRRRRLGSIEFHHGGMLERERERENDMTLACNQLKANIFGGLFDINSSRVEFIFTCQPLGERGGGCQSSQFPIRSSHSVYEGGREREPASFKEIFASRRIMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGGWNGERERDYLALVYLVTALVPSDTACLASSPGSNRRTAVWISREVMVERLLYQSTKTRTVPAAYKKQSARSKGSSLSHFASNDRLAIMSGRGKQGGKTRAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQSVLLPKKTESAKSAKSKAMTAELWKRRSVLKSWAISRTSRWKGSLRMSSSVDFCFAASPLSHEGVTAAECNPVQSCRVKAIFERRIMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
The following text describes a protein:
Function:
Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MLPRGRPRAMGAAVLLLLLLLVVGFFLFGRDPDYGLGTTATLDEDPYRSRNLSASSPQLLLPPKCEMLHVAIVCAGYNSSREIITLTKSLLFYRKNPLHLHLITDAVARNILETLFRTWMVPAVVVSFYDAEELKPLVSWIPNKHYSGLYGLMKLVLPSILPPSLARVIVLDTDVTFSSDIVELWALFDHFSDKQVVGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLWLDRLQQTGWEQMWKVTAKRELLTLMATSLADQDIFNAVIKEHPHLVHPLPCVWNVQLSDHTRAERCYLEAADLKVIHWNSPKKLRVKNKHAEFFRNLHLTFLGYDGKLLRRELFGCPNQFPPGAEQLQQALTQLDEEEPCFEFRQQQLTVHRVHITFLPHQPPPPQPHDVTLVAQLSMDRLQMLEALCRHWPGPMSLALYLTDEEAQQFLHFVETSPVLSMRKDVAYHVVYRDGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLELDSRRKTALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHSSTDYSRWREAQAPYSVQWSADYEPYVVVPRDCPRYDPRFVGFGWNKVAHIIELDAQEYEFLVLPEAFSIHLPHAPSLDISRFRSSPTYRNCLQALKEEFHQDLSRRYGSAALKYLTALQQARSRA
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MGSCLSSPSSSSTLPRTRTVDYKVNYIARPTRTKQQVRAKQSTKLCLICMDEKSPSDIFRGTTSCTHSYCTKCTVRYVTTKVEENAARIKCPDMNCTQLIEPYTLYCPFEKCSAVPWHAGSGCKETKKKTRNSDKEDIWLRRRSGGGALNANSTLRKPLVVCI
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Sequence:
MIPQSNPTAQRRSGDAQNTNNVAPNSVATTTDTALTASTQSGSSSNNANKKLEYIGVYKIGPEIGKGSFATVYKCIDTTNNKAVAIKSVYRSKLKSKKLLENLEIEIQILKSMKHPHIVGLLDYKQTTSYFHLVMDYCSMGDLSYFIRRRNNLVKSHPVISSLLHCYPSPEGSHGLNEVLVLHFLRQLSSALQFLRDKSLVHRDIKPQNLLLCPPVHSKQEFIDGEFVGMWELPILKIADFGFARFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPFKAGNHIELLKNIEKANDKIKFPSAAQVPEPLKQLIRSLLKYNPTERISFNEFFNDSLITCDLDDNDQPLETSQMDENLFISEYISPIAPAERSQFFKEQKKNDSVVRSPSPTTATTATPRQDNVVQQMTKITSPVPDDFALSIARNSSEFNLKKDDMNLEKDYVVVEKRAVEVNALADELAHAGAGADAIPNSRKNSDVDQTNRLASSQQQTETASYRRSSSSGSQKRPSFSERRISLSLSPTNALTKAIGLASNRLFGLTTNSSHSNVSAIAEDDDSSTSNNDASSFSTVIPSTNNHVLLQKLNLATIGEPGTEFDLGSVSNLDEQILDKLELIANIANAVNLYADVKFSQIIPSPPSSDGIEDDTEMLPPKIIHMISQEGIGLYIKTLSLLGRAMDIAGQWWFEKYDAVHGERPSFETTVRINQIVQWIREKYNISLERLEFLKSKSDFTAEETIEDNEPNGTTRVQQAIFAAALGIARETALKELLRNSTDIECSYVTSIYMLLAILEDLEESDRQEVKKIIEKINSRLKNFMGK
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MCCLFPCCGHAEDDGNERGMSKTSSRSCTDICFLFVFLIFCGGLVAVTMYGLERGDPYRILYGSDSFGNTCGRENEALRVAGNESIRVPHSGRNMTDKRFLFPLDFRRPLSTLWVCVEACPGQMLMSHGEIERQNVLGNAVYNYKTCLKTGLVQSYTIKLEIRVKPEIIWFEGAMKNESGMNISLCVDETSTRHATAHTHDGHCPVLPVHPSSAILNRCLPNDLLSVGMGLATEVLNVVKDVDWVRTCVSSVMASSWAVLQSIGLAVVLASSWAILQSIGLAVDEYGSDEDEYVLSLTMVFLLRFLAPVAVYFVYVLVVIVFGGISGGLWYAWWTAHGHERYGVDETMESATTSSFLSTPRTTRLAEYYVDEKGEVQKREGDSLPMAALTISSILGQEATVSEQALIGLALGASVITLFIILLMWCLLPRGKLLVNLFKQSGQALAAMPCLLIQPLSTAICVLLVGGYSAANALLVYTAAAPVPTLHDDTQLAVVTYNVTQTQKYMLAYQAIGFIWLCEFAFAYQRMLIAGAVAKWYFDRSGRSPVCGSRWNTIRFHLGSLALGSFIITIVRIPRYILMYIYAKMKASENVIVQKLLACCICTLACIEKCLNYLNYNAYTVIAYTGQSFCPAAKTAVNVLLDNAIHVATINSIGDFVLFLAKAAVGAACASLCLILIKDDASITNWWPQLLIVGLAAYQVANCFISIYEMVIDALFLCIAEDFSMEKDGASQRRAQPEMMDYMERTIVHEESIRSSRGLKRREGRGTRDEKETFEMY
The following text describes a protein:
Function:
Specifically required in males for proper segregation of autosomal bivalents at meiosis I. Expression is required in the male germ line prior to spermatocyte stage S4. May have a role as a bridging molecule maintaining adhesion to hold autosome bivalents together via heterochromatic connections (By similarity).
Miscellaneous:
MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and tef. Teflon has a function unique to Drosophilids.
Subcellular Localization:
Nucleus. Chromosome. Note=Male meiotic chromosomes.
Sequence:
MSTFLDMLSGSQCVSLEKCGDVVVSTNDCMIALYCHFCRDLFTQLPEFLRHLQGAHSDVLHFTKEHNVYSVEELMSGEQEDAQSVGHNSSSSDSRGLAKSEDSRATEATEDNSDNSPVKSEEKGSQNEINLLAEVTNILLQTKEKEHINDKLKPENGGFKGPRKKANSESNSLRICNLKSHTIARTSRKRMSIIKNRILRVIDSDLSANHEMKPSEPNSKILITEPIQEANIPGICLETPPKPIPSSSNLSVRKSSLTEANVSLAHTNYAAKKTTPTLPKLLNCAPKPILPSQQAQVHSGSSGIHEVYHISKAASQVPKEMKSFPIEITQIDVFPPRILPETSTTSDKEEDVNAPVENNTRSLYNAQNLPKDKPKKFFKKRGELWMKNEGKITKSKVNPIIVKQVQTSNVKSSPGKTQIRSSDKTKCFASEFNSTKNRKLKMENFIALKKEDPCSIRSIRLNKMATIGNCEILKVVGLPAITDNQIEDTLLQDELETMRKKADQFSKIYRKYDSIWNYRKIVPPGKPEHISQKMFALTREVNQTMGCNLPNSAIKNIINQISVWHYNIYTKNIVLDTISETARYTLNLFSFLPVSFAYFCKCCDDIFTLNEDYIRHLVSQQARYQCTKCIKTFKYQGHYDKHMRTVHP
The following text describes a protein:
Function:
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Man(9)GlcNAc(2)-PP-Dol to produce Glc(1)Man(9)GlcNAc(2)-PP-Dol. Glc(1)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG8, the following enzyme in the biosynthetic pathway.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MEKWYLMTIVVLIGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHWQEITFNLPVKQWYFNSSDNNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILLYPGLILIDYGHFQNIYNSVSLGFALWGVLGVSCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASFVLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCFTFLSLLPACIKLILQPSSKGFKFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFSIAVRKYLPCFTFLSRIIQYLFLISVITMVLLTMMTVTLDPPQKLPDLFSVLVCFVSCLNFLFFLVYFNIIIMWDSKSGRNQKKIS
The following text describes a protein:
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MNARFLRPFARAAFRAPAAARPSAMARPALVASQSKKTEVGPQQMTVLKSAMPQLIPFFFVNETTVAFILLPSLIYIFSKYILPQRVRLFAARLFISKL
The following text describes a protein:
Function:
Could be part of an ABC transporter complex.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MKGNALALCATGTWTASFAPVLERMVADAEKLAGSPQSIFIDVSEVAKLDTFGAWLIERLRRSLTQGTVEAQIAGLSANYSSLVDEVRRVRATPVVDAGTITITGMLDQIGRAVAGVAGTVAGLIDMLGAVLAAGGRVLIHPRSFRLTSTVHHMEQVCWRAVPIIVLITFLIGCIIAQQGIFHFRRFGADIFVVDMLGVLVLREIGVLLVAIMVAGRSGSAYTAELGSMKMREEIDALRTMGFDPIEVLVLPRMLALVLALPILAFLGAMAALYGGGLVAWLYGGVDPEAFLLRLRDAISIDHFIVGIVKAPVMAAVIGIVACVEGLAVQGSAESLGQHTTASVVKGIFFVIVMDGVFAIFFASIGM
The following text describes a protein:
Function:
Mitochondrial solute transporter which transports branched-chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MGSRSAVWATKGKSPGNMEGKRNIQIIEWEHLDKKKFYVFGVAMTMMIRVSVYPFTLIRTRLQVQKGKSLYHGTFDAFVKILRADGVTGLYRGFLVNTFTLISGQCYVTTYELTRKFVADYSQSNTVKSLVAGGSASLVAQSITVPIDVVSQHLMMQRKGEKMGRFQVRGNLEGQGLIAFGQTKDIIRQILRADGLRGFYRGYVASLLTYIPNSAVWWPFYHFYAEQLSRLCPQECPHIVFQAISGPLAAATASVLTNPMDVIRTRVQVEGKSSIILTFRQLMAEEGPWGLMKGLSARIISATPSTIVIVVGYESLKKLSLRPELVDSRHW
The following text describes a protein:
Function:
Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSTSKSENYLSELRKIIWPIEQYENKKFLPLAFMMFCILLNYSTLRSIKDGFVVTDIGTESISFLKTYIVLPSAVIAMIIYVKLCDILKQENVFYVITSFFLGYFALFAFVLYPYPDLVHPDHKTIESLSLAYPNFKWFIKIVGKWSFASFYTIAELWGTMMLSLLFWQFANQITKIAEAKRFYSMFGLLANLALPVTSVVIGYFLHEKTQIVAEHLKFVPLFVIMITSSFLIILTYRWMNKNVLTDPRLYDPALVKEKKTKAKLSFIESLKMIFTSKYVGYIALLIIAYGVSVNLVEGVWKSKVKELYPTKEAYTIYMGQFQFYQGWVAIAFMLIGSNILRKVSWLTAAMITPLMMFITGAAFFSFIFFDSVIAMNLTGILASSPLTLAVMIGMIQNVLSKGVKYSLFDATKNMAYIPLDKDLRVKGQAAVEVIGGRLGKSGGAIIQSTFFILFPVFGFIEATPYFASIFFIIVILWIFAVKGLNKEYQVLVNKNEK