lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
Subcellular Localization:
Nucleus.
Sequence:
MMAMDGGNLKDRFSSDPPRVIGGIEFGALSPQEILKLSEVEVATRDLYDLQKGRAPMEYGALDPRMGVSSNMSKCKTCAEPLATCPGHFGHVKLALPCFHIGYFKATISILQNVCKDCARILLSDEDRRKFLTELRRPGIDNLRRMQILKKVNEQCKKQRRCVHCNSINGVVKKAGPLKIIHDKFRHVGKKIPEEKTEFDNSFNTAKESIPDVERLQKKAMDDLNPLKVFNLFREILPMDCELLGMDPGKGRPETYIWRYMPAPPVCIRPSVMQDSASNEDDLTVKLTEIVWTSAIIEAGLKQGMAVASLMEQWELLQLAVAVYINSDTPQGPGQSASKPIRALTQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDQVAVPDRVAKILTYPERVTSHNIEKLRNLVITGPSQHPGANYLFKKGESLRRNLRFGDRAKIAERLEIGDVVERHLEDGDVVLFNRQPSLHRLSILAHFAQIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARTEAMCLMGVKHNLVTPRSGEPIIAATQDFITGSFLISKKDYMIDRRTFCQLLAMMSDGDMQFDIPPPAIQKPVQLWTGKQVFSLLIRPNKSSKVIINLDAKNKTFQPPPQGYPRDMSPNDGFLVIRNSQVMCGAMDKATLGDGKKDSVFYSILRDYGPDEAAGAMNRMAKLCARWLGGRGFSIGISDVTPGAELSSTKEILVEQAYAKCDELIEALAQGKLEPQPGCTPAQTLEAKIGGLLSKVREEVGEVCIKELEKSNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGKRVPNGFQDRSLPHFRKFSVTPPSKGFVRNSFYSGLDPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSARYDSTVRTSSNGVVQFRYGGDGLDPFDMEGDARPVDFNRTWTHCEYISSKLGIEPEAETINVSSVPDTPLKPFEIMAVVEEQIFALEQKLQRMDNSGNMLSVATKAARDRASAEKYVDEVDPRRDFLQSIRGFIYTKAEELATVRESRGLMGLLEKPDGDEYDGQDFDLFAPKAVIRAVNQVCRISHRMVDTFLQACLRKYQKAQVEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKAISTPIITTVLNNETELQAARIVKGRIEKTLLGDIAHYIQDEYSYAKASVRVRIDFNTIDHLLLEIDMDQIREAIIKAPKLKLKPGQVSIEEEKYIRVDIESDAVKKNGSTTIIDTDGEIFEEGVESDTAMFLRTQHLKRVLPNVVVKGFTDISRAVINIREKDNTHELLVEGYGLRHVMTTSGVIGTQTSTNHVLEVKEVLGIEAARASIIHEIDYTMSKHGMSVDPRHITLLGDVMTYKGDVLGITRFGLAKMRDSVLQLASFEKTTDHLFDAAFYMKTDDVEGVSECIILGQGMSIGTGAFKVLQPLALDKVKIGPKPLLFEEVCKQLKNVKLED
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MSASSRGAALLRSQQRSICLQCRNQTRVLAPAGVTSAPRRFYSAEASATATATATATTTTTLPPPHPPVTTSTGTHAATSTSSQIYRIKSGVILTRPPLLTRDLTPFEESFYFYQKRLNERLTAPFRKDFYFKKDTAADLDWRIKLKERHGVPAKDIGRYNPRGRMAWNDEVLVGSQTSSRKHMVEKLLADAEMRVSEDGEEIPAEDRVPVEKPMPRRTEADEKGDVKRLDRALDKTLYLVVKKKADKEGEEAKWMFPTGVVPTDEGLHETAARILAESAGVNMNTWIVGRVPVAHHVVRPVFGQKDGALLKKGEKIFFLKGRIMAGQADLTDNLHDLVDFKWLTQEELRSTLAEEYFHSVKGMFAER
The following text describes a protein:
Function:
As a likely component of a histone deacetylase complex, together with saeg-2 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging.
Subcellular Localization:
Nucleus.
Sequence:
MPPPQHPPNYYAPRRSISTITGPNRRDVDAFYQNNFPEKNGGSSGEHVPEYQASGQQHRPSIMSGQSHQNNHLPTKNYSYEPLRFSPPNVTPPPLQFSTNTDGNRKNQRVRFNELPNYSTPNHYSVPPRKCSLAPNFFSSQNSHHMYPDQYTPRTWQNNEFMPNHQVHPYHANHQQQHPQQHWRNQAASNGNHNPMYMRKHSAGHGIEIKLDHVDNPFGNPSHDMMDVTSGQPVKSEMLSPIKMETTDPSQQIASPSFLMTSTSLLKQHLHKKSHHNVPSRKASIMALKSQLRTPRGTPLNISTVPGTELPYTPPPILAPMRNGSGLFCQIVKSANSSLPVAEQSPDAPSCSTNGVDGDMKHLMNGKKRSEDGDGPSRKNGFFYMAQQMNQTNFANELEALRKESWASTSSADEKMQTERKESLESIRKASCMSDSYYEIEEGPKISDPNPHINLGKNYQARVKKWCDRQVSTSERDAIEDRDEIVFSSEILQDIDPEQITAFELLACSQACPRAGRNKELALHLLMENKGNIEAAVEDLLRSDTLDWEHYSSVFGYMYNDSVLWTPDEIYQFQDAIYQSEKDFDKVAVELPGKSVKECVQFYYTWKKDCPDDYRKLRNLRRKRQLLDINLQKNQSEEPVVPAKKISIIESGDSDNESNATDSSFIGNGHMEFRDRAFTSPMMSSPREEPIIGLSPSSKDLFGIQKNYQPTAPRAHHTPSASASKKGAQPSADGFFHCRLCDKCFEKVKSLNAHMKSHAMKARAEQEAKAHDAQVAAAAAAQLTSAVGNVVGNPVATSPLNSFANGHLGISIPSTIGNLTPQQLTPQQLNLNQQLQTQLNSLSNQMSLNSPLTPQQQLQQFTQQHLMARAMQQNLFQPVTSTPLVQPTHPLIQAGLHSIN
The following text describes a protein:
Function:
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
Subcellular Localization:
Secreted, cell wall. Membrane; Peripheral membrane protein.
Sequence:
MARSAFFFHCVAAVAACIAATAAALSGTATFYGGSDASGTMGGACGYGNLYSTGYGTNTAALSSALFNDGAACGECYQITCDQSNSKWCKAGTSVTITATNLCPPDYSKPSNDGGWCNPPRQHFDMAQPAWEQIGVYRGGIVPVNFQRVSCTRKGGVRFTINGNSYFELVLITNVGGPGSIKSVQIKGTKTGWVTMSRNWGANWQANNYLNNQAISFSVTSTAGKTLVFEDVAPSNWQFGQTFTSGVQFY
The following text describes a protein:
Function:
Involved in endocytosis.
Sequence:
MGSKLRGSRLESELDRARTEGNWSRVAELVKAAKSRQSGLPSHLAKLIEAEAEIELFLESQDVLTPRSSHSSGLKASEERLRAVLADNDAEAVYLEARLLLAKCAYVKAEGKTAIGLIDESGMEKATTAFRSLRALRLVAEAYAIKGLCLEQQWEESEREGDMMRRQRIVSSFEKAAELTISYVGELEKTLNPMRGGGGGMMGGGTLGTSLVVSSANTSLNVTVGGGGGSTTGSLQRGTRGLGGGHERIGDILEYCLERVAKLRLRETGMERRVADEGVEWYRHIMTSLGDKSTGERLQMRLSRQFAELLLRAIPDAPQSTTSKALSSKSQSLGFYSGGQKAYFCPRSRQEEIILLLLLSESLCTKDIVLGRTDDVPPWQAQAVGTAKAVYNLLTLMFTTLRQFYSLSSVFERAMKFANDDPFLWQQFALSSVSRGASSPSSSFRALRVLERSLAVAHASPVAEAPQTAAQHLVAAQLYIENGDYDKGVEHADAASLLAGAGVLKGRALLLRAVSLQQKACTSSRSFYERLQFLSESGHQLEKCIELDAHDYLTLYYAALHYAHVRDLSAARERLGRSLELHCEQPHALLLLALIFTAENDYKAAMEIVKKALDDFPSHYALRVLQLHLFIKIGRVGESMEASKHLLDLFSSRNAGGGYGSRGGTGAGVDTVIDSASSVHRAGSRWGRDNSTVYSAPLGGGGGSQNGFDVSDSGVFAASASEMGGASTHSEVSTGMGGAGGVAAGVARRYRAQASIWVSLAELFLDEGRLSDVQPCIEQAVQLFPNSAHALYLKGRLMAAKGATMSAANGASRVRAEARGAFLSALSLAPEYINALVHLASLSKEDGQMEMAEHCLKELVRVDPLDGRWWNDLGELLLARGRETEAISCLASAAQLGKMQPLLPFTAIPLVFPSCQ
The following text describes a protein:
Function:
Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity.
Subcellular Localization:
Cytoplasm, cytosol. Chromosome.
Sequence:
MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENADPRPAVQFSNLPRIDFSSIAVPGTSNPQQRQLPRTQAQHSSPGEMASSPQGLDNPALLRDMLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLEAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVAMLYINCRVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLACSFSILEEQPMDMLLGLDMLKRHQCSIDLKKNVLVIGTTGSQTTFLPEGELPECARLAYGTGREDIRPEEIADQELAEAIQKSAEDAERQKP
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Sequence:
MAHLKIHGLVQIRSTNRSKHTRASQWKEAVIEIVERKQKVNLVVSFKLEERRRVFQLGDNVTGVVVSGELGLYHLDLTLRDDTSLLIDKLSSADVEHLKSFLDSSTPCESQQPMESMSNQDTLEISDPFFRENQDVVCVSLNTALESGTLLSRKMPLCMSNTTGSHTEKKRGEKQGRKRKTEPSPSTVEVTTKDILKENNPEQKKKSRRYYSRNRGGKAEKAVALREQEKRNNWKLEPAFSSKVYGKSTLDGTVLPIATCSDDRDLSIFGLEIITHNGIQPPPDNYLKQLKREGFPNLGNTCYMNSILQSVFGIPTFAKDLLTQGIPWEKVSYDDLIMPLSQLLVLKDIRDIEIKGELLTSVKKSISTVADTFSGNEQNDAHEFLSLCLDQLKLNMEKVNAMWDTERKNEPTCAGAKRFVCPVGANFEFELHSSIICEGCGEATLKTEVSNYLSIDLHHGTKTHPLSIQKSFDLFFTPEKIEHNCEKCKNKNSVLKYTLRRLPRVLIVHLKRYQVTTDLLPVKSEQPVEISQYLNISSHCHENRKLPFPLINTPPKGDYDIPNVSPGLMPEIFSQSMSSKKVISESSDPLVLQVGSSVDAEIQSFQIMYEDESEEEQQRGLESGSMLDPELLKTENRVFRQKISPAPDSMMGDGYSFLPMLCEPMSIQDPGLAEMGLQEVPENPEFKYYGKPDGRTNSELSKLHQNHGGRIKGSYLPASFANMRSSLEDPEKDLSRSSEFEEDDPHSFALGSDESKDEEMGDNLHNYRLVSVVSHFGSSPNSGHYVSDVYDFQRQAWLLYSDVQVFENPDPSSQENRLHTGYIFFYMHNEIFEELLKKASECKVLSTSKEEKRDIDYFSTLLNGLTYILEEF
The following text describes a protein:
Function:
Reversible hydration of carbon dioxide.
Sequence:
MLVLNNLRGLTSLFFGKQVRGSSRSHQMIPERACTRGSCVPRNRNKFLHPLWRSPVSVPGGTAQSPINIQWRDSVYDPHLKPLKIYYDPSCCLHVRNTGYFFEVVFDDSTDRSGISGGPLGNQYRLKQFHFHWGEVNDWGSEHTVDNQVYPAELHLVHWNSVKYQNYKEAVMGENGLAVIGVFLKLGVENKELQKLVNVLPEIKHKDTHVALNRFDPSCLLPSCQDYWTYGGSLTTPPLTESVTWIIKKKPIEVGNNQLAEFRRLLFSALGEEEKKMVNNFRPLQPLMNRTIRSSFLT
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MEIKSLKKADTIFDSYVELALCAESSVFHWIYLRDNCTCTECFHDATVQRTLDTFDELPWKVCRQSYSAEAPKEAEFEIREGKLRVRWPDEHVSEFSEDWLRRHSYQPPLSTKPKALSLPAKSHWDRAEFNKLLGDGAHFCTRYDNLPSELPTVLREIYEFGFTFVRNVPVSIEATKTVSELISIIRPTHYDTGVWEFTSDLAKHDTAYTTVGISMHTDGNYWHELPGLQLFHLLEHSGGEGGETQIVDVAKVVDQLRELAAQDESWRTTYKVLTEHPLAFHQSGELDSVFYQADYPTLTLDATGELEQCRWNTSDRISQAPLAPGSPYTVPQVYQALFRLDSLIKDEKNYVQFKMQPGTIFIFDNWRVLHARTSFTGCRRLCGSYLTRDDFLARFRSIVFDREAIKDEIYQ
The following text describes a protein:
Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine. The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for recruitment of vps-33.1 to the HOPS complex (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with vps-33.1 but not vps-33.2 (By similarity).
Subcellular Localization:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Sequence:
MGESHAPSKPKLDGELCLRPSSSVFLGDQQLYFTQEYLRTNSLNLKYVVYFTACQFSGPIAVAYSPRPASWYIWIRTISGRILKRDMAFNEPVFMEWTRAHCLLVLNKAGRAHIFSSLGEKISEVIFDSQMSDVHECRTFATSRGDSGIAVMDVDGQVSVVNSVSEPVIWSMKPPYSEMPTAWTAFQPHSQLTHILLIFEAVFLMGCQGESLREQSHAASWVDSNTKYVKCVVDDARSRIAMMTESGKIQIVSIDLSTCFCTVEITDHDIAKCINFGWVGNSAVFVQMSPSLIVFVNVSARRKPGDEVQIYEKMTANAKISIEPDGIRLFESTQVEFVEAASREKIAVLNRNPNEDGAHLYKAAQEMSQGTGHNSFAASTVIQDLYKAIDDCISTACDTWQPEEQKLLLKAARFGMAYTNTTPDTTKLMRAIKEIRVLNELRMVRTGIPLTHRQFRAIGETCVINRLIDMGSYSVAIKVAQWLGGETSENVDRVLLEWVRRSISKVSKSNMKMDQPALEALDEKISAKLLQFPHVSIADAARRAIEAKLPELARLFIRRETDDANHVAVLLQLNDVSAALQKASASQRPQLIHQVVRHLMNSESRSSYELAISRIPLAQCLYQDLVRQEGETRGASSRQMLALLEQASDFERQTLFHFDVAETERNPDERLNALRRAKDAAKSMGDKAIEEILNDVSAFAPLQIQRGQADMSVRDTVIEMAHDTAKVAQLKQQARLTDKQVLLWTIEGLAKKGKMEQLFDLAQKRSPIGYAPFVKACVRYKRLDEIKKYFAKVNGYPDLVAAHLAMKNYVEAAKLAYDRRDRDVLHAVHMKSHEDPTQCPRVGQFLRSLDQN
The following text describes a protein:
Function:
Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MGSSSFLVLMVSLALVTLVAAEGVKGGIEKAGVCPADNIRCFKSDPPQCHTDQDCLGERKCCYLHCGFKCVIPVKKLEEGGNKDEDVSGPCPEPGWEAKSPGSSSTGCPQK
The following text describes a protein:
Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular Localization:
Nucleus.
Sequence:
MAASEQSSVPDTDIPDYEYIGVNTKPFRIGSVRDGWLTRLRPKDYSYQQEDKDTFEANFAEAMGISEETMAELRSVCSLDSLRCHAEDELPDTEVVPPDSTLKTLIQRKKRQDHKASLKVNKNRHDLYADELERLIVGRTPKTESDRIPEGEIILTINVYYPAVFEKFNYIRPHMTLLMTGSHNLTELRDAICCISDLQVCGEFSRTPDMAPDFLCKDHFKSAFFFFEGVFYNDMRFPECQDISITTINWAKSHNFPPFTQAKMEDTLLQDLKLKVGFPYLYCHQGDCEHLVIITDVRLVHKYDCLDKKLYPMLTHKHKVLTQKCAVCHLFIARWYTTSDQFAPSDPCLFCDKCFRMLHYDADGNKLGEFSAYPYVDRGALN
The following text describes a protein:
Function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain.
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISSTLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPVLERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSNSSSLWRSSGAPETLQRVSGISFPTTELLRVWEAWREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIRAEYAHRGFSEVKTPTLFSTKLWEQSGHWEHYQEDMFAVQPPGSDRPPSSQSDDSTRHITDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGGLGGLTRLRCFQQDDAHIFCTTDQLEAEIQSCLDFLRSVYAVLGFSFRLALSTRPSGFLGDPCLWDQAEQVLKQALKEFGEPWDLNSGDGAFYGPKIDVHLHDALGRPHQCGTIQLDFQLPLRFDLQYKGQAGALERPVLIHRAVLGSVERLLGVLAESCGGKWPLWLSPFQVVVIPVGSEQEEYAKEAQQSLRAAGLVSDLDADSGLTLSRRIRRAQLAHYNFQFVVGQKEQSKRTVNIRTRDNRRLGEWDLPEAVQRLVELQNTRVPNAEEIF
The following text describes a protein:
Function:
Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the prophenoloxidase cascade.
Subcellular Localization:
Secreted.
Sequence:
MSFDLTTPFDVIKTVSLSARYSWTTSQKGATLNITYNDKNFVLSSSLQLSTRASNITFQATTPFEGFQNSFIEIKYDIDNREELLASRVSVDDHSYSFVVGGYIEDKLAVFKWNLNSPLTGWTDAKFVAKIDLSSENKNLEISLEKEGDLKAIAVSGKFIGSTLDFNLRTPFRGLNNFNVFGSLNRSKRSLEMRMMNDAGQASLAGNFNSLRFNMKTPFERAEQISWEVTKTGEGSYKAEWRRNDNYATFTIEKDVSKQSFDLNIKSEFRGWEILALTGRLDQETKQAYLSGAINEQKITVTGSGSITNKIKFSMTIETPYENYRQVKAQLNYAKRKNAIKLEASSSSSDFHLLWSRSGSGLEAHLIVPNSRQNTEISINLTPTQGKITITSRFEPIRDYLQEYHVNLGQNEITADHIIKLNGHEVFKMDFERNAPEQKVHLEIHTHVAERHTTIHFHREGFSKLNFLFKREVPQYGEKHFKVDITGSGALPQKGALDIVVENTFREPAKTINARVEVDRTGARKKIMLEVSPRQSRVYIFNLEYIADLESPQHGDFTLKITTPNNSPWQNISGNWNVEDPNDATITFTVGNVTYNAKGKLTLRESTMILSSTDPSAENIYLQWKFERNGDTKDYFLKLGRKSRYGMLKLTGTITDIAHVDIEGGFKAGPFMPNEFLFTSMWGKSNGVVTGEGTFDYGNYHGSHRLVKFERNAERKSASFEWSATSNIPQYNSVSVSGNYDFNHKVVIFVVINADGRESKIDINIADINPTSSRNTAMISIPLLGPTFKRTELTVSHDFSHPNRKSISAVAKFGRSESFINAKWNRSDGFDTLEGNIEAKSRFLGDFLINVRYDMSNIADAHAEVDYLRTTTDGDKKEFKLNWTRKSTDDHLENEMVFDSNFETLSHARAYANADYGGIFKLLSGLDWDDKKISLTLEVRKNKISGILTTPFEGFETLEIDLQYKLTGKDKSVKATYQRGDRKASFNMEMSTKGKKGGSFKVDLTTPFEVVKNLHIDGQYENKVAQINYQRNDIQMNFNGKANIKSSKASFDISFTPPSGQNIRIAASYDVQDFIDGTGDEEKELASLSLEFEGNSMDFSLHGFRNDDRLYVMIHGTSSFAVLKMFHLKLDSELNTEARDGTFELTFNDFKFNVSNHFERRANNGYYFRSKIESTLTPLPALIIGLGREGQERIITIGYGEDKEITFSVKGKNNFLSGFSGKVDIPSIGYEGVEYDVDYSFPGDNHLQIKVEIDLNENGQEVEATFFLDSEGIKARLSSAVLGDHSLRVRRSVAPDGFYAEAGLDDYNLKLRGGFKNEDTARGVQLEGEVFGKRFLIDTLFQSEGKRYSEGKLIIHTPFHGMEKMGGLFTWSNQNKKIMAHAELHLPSYTTPTITGEISLDLKKKINGYVTLDVAGEEFTLKCNLAGSSISQGYTGSLEFYTTIPCCITCCGDR
The following text describes a protein:
Function:
Acts as a probably catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. In vitro, POP2 has 3'-exoribonuclease activity with a preference for poly(A) RNAs, but also degrades poly(U) and poly(C) RNAs. Is part of a glucose-sensing system involved in growth control in response to glucose availability.
Miscellaneous:
MISCELLANEOUS: Present with 1520 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQSMNVQPRVLAVGGEQFFSQRQASEQHQQQNMGPQVYSPKVNRARMFPQGMPVNTINGSVNQEMNNAYLLKQKNEPLLTQQQQQQQQQQQPFNIGTPVSVASLPPGLNVLQQQQQQQQQQQQQQQGVGLNRPLASQLPKHLTNQSMPPIFLPPPNYLFVRDVWKSNLYSEFAVIRQLVSQYNHVSISTEFVGTLARPIGTFRSKVDYHYQTMRANVDFLNPIQLGLSLSDANGNKPDNGPSTWQFNFEFDPKKEIMSTESLELLRKSGINFEKHENLGIDVFEFSQLLMDSGLMMDDSVTWITYHAAYDLGFLINILMNDSMPNNKEDFEWWVHQYMPNFYDLNLVYKIIQEFKNPQLQQSSQQQQQQQYSLTTLADELGLPRFSIFTTTGGQSLLMLLSFCQLSKLSMHKFPNGTDFAKYQGVIYGIDGDQ
The following text describes a protein:
Function:
Probable zinc metalloprotease whose natural substrate is unknown.
Sequence:
MKIYIQPLSVNSHTVEVLANSLPKIFNAEVFVLPASDVSLKCYNASRRQYNSTCILRMLPPIKVTLGVTGKDIYAKGMNFVFGEAELGGARAVLSVFRLTTADSELYRERVVKEAVHEIGHVLGLKHCSNNCVMRFSNSVQDVDRKPVSFCRECASKIRY
The following text describes a protein:
Function:
Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MLLNQHTLFIALQFFIPWELTHLMFSHALLEIPVQSCNLTMTSHNFQHILSWKSNSIATTPIYYTVWYKIWSTVEEWKAVEDCTNITTLSCEITDFYEIRECYFINVTGFSGEEKLVECVLNFFPISETILDPPEISIFNFKDAVNVTVHHPTFLSKLKEIEKDFFSSVVIKVESNGSSSQDLEVEMADKENVTVTTDPLIPNSNYCISAQWKLVPSDKIQSSSKCFTFSPSQESEKSTLIPVVFVVCFIIILLITTFVKTLKNTGYICRKPIPSPKALDFPPVTPGPLRLHYEKITVVEIIYKIKKKEMLRESDDKSDNEDKSDSDYESTQRTGNGYIMNCLTSRSLSQDSTFTQKEGNPTGSGPKDPECPETNPPLADAGSATSNQLKAGPDEKGVSRLWSFISEGSVLSSESEDCSNFNVNLNTVFVGDPGDNNASEEDDAQILLPVQEDKTNLVDSDGSELLSQAACGKTPLLHVPSAEHLWSENSSSDESVTSEPDKDQRGGYLRR
The following text describes a protein:
Function:
A leucine-specific metalloprotease that plays a role in controlling the amount of leupeptin during colony development. Degrades leupeptin into three components, acetyl-leucine, leucine and argininal. Has a strict preference for leucine at the P1 site.
Subcellular Localization:
Secreted.
Sequence:
MSLSVSRRLAAVTAFAVAGLFASAVPAALAAPSAVAAAPTPPDIPLANVKAHLSQLSTIAANNGGNRAHGRAGYKASIDYVKGKLDAAGFTTTLQTFTSSGATGYNLIADWPGGDPNSVLMAGSHLDSVTSGAGINDNGSGSAAVLETALAVSRAGLQPTKHLRFGWWGAEELGLIGSKYYVNNLPAAEKAKISGYLNFDMIGSPNPGYFVYDDDPTIEQTFKNYYAGLGVPTEIETEGDGRSDHAPFKNAGIPVGGLFSGADYTKTAAQAQKWGGTSGQAFDRCYHSSCDSLTNINDTALDRNSDAVAYAIWTLGAGTPVPPGQSFENTADVNVPDSPAAAVSSPITVSGVTGNAPATTKVDVNIVHTYRGDLVVDLVAPDGTVYNLHNRSGGSADNLVQTYTVNASSEVANGVWNLRVKDTAAQDVGYINSWKITF
The following text describes a protein:
Function:
Involved in peroxisome biogenesis.
Subcellular Localization:
Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MEKLTRVFERYQEYVRTSPAAASHLESTVRALSYLIAGRFSDSHEISELVYSASNLLVLLNDGILRKNLSRTLPMSISQQKLLTWLSVLEYVEVFVEMAAAKMWGDAGRWLVIVLIQIAKAVLRCLLLFWYKSGIQTSPPIIPLDRDSQLCSQDNNEEEDDEDSSFVGQRSGRVVRPLGSAPSLQSRLWGLPRKKKVSRNQEEELHSSPTPLGLQETIAESLYIARPLLHLASLGICGKRSWKPWILSGLLEITSFSLLSDMKALNRRERAEMRRRAFLLLYYLLRSPFYDRYSETKILFLLRFLADYVPGVGLVARPLMEYLPIWQKIYFYNWG
The following text describes a protein:
Function:
Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression. Involved in mitochondrial lipid homeostasis.
Miscellaneous:
MISCELLANEOUS: Present with 1600 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMTKAFFNKLPFEVFRRYVRTGKSIPQRSPRTRKSLLVGGTIASAVVLYNFNDTFHDSVKHTALTTKRIAVVTQATTRCFYHYKRALNKSYENKKEREVALNKCHKMCALITLHALRSNGGIYIKLGQHIGAMTYLLPKEWTDTMIPLQDHCPESTYEEIDELFKEDLGTSIEDMFLEFNKTPIGVASLAQVHVAKLKNSDGKGSSVAVKCQHPSLKEFIPLDVMLTRTVFELLDVFFPDYPLTWLGDELQSSIYVELNFTKEAENAEKTRHYFSKFKKQTALKIPKVIESHKRILIMEYVGGKRLDDLEYIDSHGISRSEVSSCLSHIFNNMIFTPNVGIHCDPHGGNLAIRSVKPAKDNGYHNFEIVLFDHGLYRYPSTRTRRLYAKFWLSLLFDKDQTKMKKYAKGFANITDEQFPLLAAAITGRSIDAALNYDISTSRTQEEMDVMANGILEGTLLSDLMSILSRIPRVVLLILKTNDLTRHLDECLQNPLGPERTFLIMTQYCAKTVYDEKVERINSEYARWSIKWMWENLTNWIVYERRINQLYFYDFVLWWKKFIPKTWLSS
The following text describes a protein:
Function:
Exosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS). 2-O-sulfatase active on unsaturated non-reducing end hexuronate units. Has a slight preference for HS-derived structures. GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract.
Sequence:
MGLALCGAAAQAQEKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPSRAALWSGMMPHQTNVRSNSSEPVNTRLPENVPTLGSLFSESGYEAVHFGKTHDMGSLRGFKHKEPVAKPFTDPEFPVNNDSFLDVGTCEDAVAYLSNPPKEPFICIADFQNPHNICGFIGENAGVHTDRPISGPLPELPDNFDVEDWSNIPTPVQYICCSHRRMTQAAHWNEENYRHYIAAFQHYTKMVSKQVDSVLKALYSTPAGRNTIVVIMADHGDGMASHRMVTKHISFYDEMTNVPFIFAGPGIKQQKKPVDHLLTQPTLDLLPTLCDLAGIAVPAEKAGISLAPTLRGEKQKKSHPYVVSEWHSEYEYVTTPGRMVRGPRYKYTHYLEGNGEELYDMKKDPGERKNLAKDPKYSKILAEHRALLDDYITRSKDDYRSLKVDADPRCRNHTPGYPSHEGPGAREILKRK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MFSETFVPSIFSYKHRLLHLSVLFFIVPYWYSYYNDQHRLSSYSVETAMFLSWERAIVKPGAMFKKAVIGFNCNVDLIVSGVRVVDALNTTCSEGKDQETLETLADLHQTFAHFFQRGAAAERYMSSEDQFNLLVAESEASTRSHHHIGGNAALMADRIAANFPSTEVYLVGPIGPRSQALLHPSVKRTNSTRILKDELHVILEYKQGEILGDWVAPSSSRFITSHDHFSGSMVVMEMFFKAIAQFRPDLVVITGVHLLEFQSKEMRQEKMRLIKRNLLQIPPKVPIHLELGSLADEIFSTDVINKILPYVDSLGINEQELTFLSHIANGPHMEEYPVQAGTVHVHKVVEMLHWLLKTYGRDPTGQIASKTGYRLSRIHFHCLTYHIMVSSGTDWSNLAAGLAAGARIAGRLSCNIGANTMDSELLEIRTPANFVLDKKIEKNYQFEAHNPIASWMREDVLFVFTPVLVCRLPSKTVGIDDAISATGLLYSQFYRLNRPTHW