lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MSETLYTGISQLATPRPGPQRGAAMGDLHIIEDAALLVRGGVIQWVGPRAAAPTATHVHDLGGRAVVPGLVDPHTHAVWAGDRLSDWEAKLQGATYEEILARGGGIRSTMRATAAADVAELVALARPRLASLRASGATTTEVKSGYGLDFDAELRMLRAVRELQAEFELRPTLLIHVPPQEGRAEYVVGVCAELIPQVAREGLAEALDVFCEKEAFSVEETRTMFAAAQAHGLRVKLHADQFHAIGGTELACEVGALSVDHLEASGAAQIAALAASETVATILPGVTLHLGLPAAPGRQLIDSGAIVAIGTDLNPGSSPLFSTQLALALAVRLCLLTPAEALSACTVNAAYALGLSDRGSLSAGQRADFLVLNGQDWREVAYTLGGNAVAEVYLAGAQL
The following text describes a protein:
Function:
Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells, facilitating the establishment and dissemination of infection. PscF/SctF forms the external needle filament that protrudes from the bacterial surface.
Subcellular Localization:
Secreted. Cell surface. Note=Secreted via type III secretion system (T3SS).
Domain:
The N-terminal part (1-11) is species-specific and essential for export/assembly and the function of needle.
Sequence:
MAQIFNPNPGNTLDTVANALKEQANAANKDVNDAIKALQGTDNADNPALLAELQHKINKWSVIYNINSTVTRALRDLMQGILQKI
The following text describes a protein:
Function:
Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). May play a role in the regulation of mittotic entry via ubiquitination of aurka (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSNLGKSTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA
The following text describes a protein:
Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Sequence:
MVNFRVTFLACAGLAAASCPYMENEAPIKRDGAAQSPKSTDEFMAQYEVDDKDVYLTNGFGGPVEDMESLSAGERGPTLLEDFIFREKIMHFGAHGVFTSYADWSNITGASFLNKPSKETPVFIRFSTVAGSRGSPDSVRDVRGFAVRFYTDEGNFDIVGNNIPVFFIQDAIKFPDLIHAVKPRQDNEIPQAATAHDSAWDFFSQQPSSMHTLFWAMSGHGTVRSYRHMDGWGVHTFRLVTDEGKTKLVKFRFRTQQGLASRLWEEQQHAAGMNADTDRQDLWDAIENGYYPEWIFEAQIMDEEDQLRFGFDLLDPTKIVPEDLVPFTPLGKLTLNRNPRNYFAETEQVMTPSSTATEDQTLNSYQSTNPAFQYHTNQRDGAGQMYIPLNNAPYSPNTLNAGSPKPANQTQGRGFFSAPNRSTGGRLVRAVSSTFADVWSQPRLFFNSLLPVEQQMVINAMRFETAQLTSEVVKNNVLIQLNRVSHDIAVRVAEALDMTAPAADDTYYHDNKTTGISVAEKKLLKLDGLKVGYLSSVSSNGDTAAALKTALNDLKVRFSVVGERLGKGIDQTYSATFAGQFDAIVVDGQAEALFMPAGSLANSNTTANATKAYTTLYPAGRPLSILQTGYQWGKAVGVIGSSSAAFSAAGLQAGTPGVYHFEAGNSTKAIVDQLAEGLRTFRFLDRYALDQ
The following text describes a protein:
Function:
Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins. Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO. Has no catalytic activity towards oxidized glutathione (GSSG).
Sequence:
MLKKLQYDLFVIGGGAGGLASSKASALLGKKVGIADYATPSPHATTWGTGGTCVNVGCVPTKLMPFSAKMGEIRKDQIAAGYQGVESEGKHNWKQLIETVQKHIKELNVRQESSLKDHGIDYYNKFAKFIDRHTIELTDVKGEKEIISAKNIIVCVGSRPMLYQDPKLVITSEDVFQQTTPPGKTLVIGASYVGLECAGFIHGFGFDTTVLVRTRVMRNFDQEMASKVEGYMSDGGIKFVKRALLQSISAVDNGKRRLVKWVRDGVVEEDIYDTVLYGIGRQASTKQLNLESIGVKIDARNYKIMADEYDRTTVDNIYEIGDCCLKRQEYTPIEVMDGRKLDKRMYGDSNEIMDYDDVDTNIQTTIEYGSIGLQEERAKKKYGDDGKKIKRTKTKTKKWRIRQRDDEKYCGGKLIVHKESERIIGYHTLDLKLLRQLKAQQWL
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Sequence:
MKRNLTKDRDILTVGKNLEYMVQAVKGSLTESQQSQFFNCSNDVEVFKFLWSLDFTHDVLSLEEEYERKSDDKCKNFRQKGNEYFKKQSFLTALREYNMAVIHAVYDEHLNGQANKIDGDVKPHDDINVTEMSENDDKRSEVDDGSEISLALGNRSAALFQLGKYQECLIDIETALRLRYFKNSIHKLLHRKGVCYLKLNSVEKAKDSFKLALEYLESVKSHIEDKMYISWKKTIEKCISQCENETETTNENNENSEIVSEFPLKLSKESHETHPEAVKSLEIKGEKSCNSFVVSRDEVGTGDVLVIERPLVSCLFQDRSKEQRCYNCLSRIPLVSYPCFTCTSVIFCSQKCRDASYNSFHKHECRFFALLGENMCSDVGHLAVRMVMKLGVGEVLQIFEKAGNGDNNMNFDRDDLKNSKDVVEKCKRLYDLEVVGFKKSPTNSVNDISKMIEIPLLSCFLAKYLTLTNYISLRPKSDENTTNITTNVLNCAHANETIRPEDFYRLGAVLINNIRIIKRYAKLIRLTTKFGDAEDSQSQAIGIALYPNVISQFKHSCDPSADVTFYNDLAVVRAIREIFPGEEVSISFGPLFHEVKLEKRRCMLWNDYYVMCNCVACFNKWPVLEEMFQDAPGYKCEKCRSPLTSSDKVDKKNLRCPYCNHQQNLEKIVHQLQNSFDSYASGINEAMSGNHGYALPCLVGHLRLLHRYLRQPWPDLVACQEAVKMCYRLQAAER
The following text describes a protein:
Function:
Encodes almost entirely the C-terminal domain of poly(A)-binding proteins (PABPs). Plays a role in normal seed development and growth.
Miscellaneous:
MISCELLANEOUS: The MPC locus is imprinted. Only the maternal inherited allele is expressed in endosperm.
Sequence:
MNRLCFFNKVVKVARGDSPPFDLASLPPKEQRDLIGETLFFMVEELEPQFAPKITGMILELDQDKVLHLLVTPKAFKEMVKEAMEVLAHSFLQQMKIARGKRC
The following text describes a protein:
Function:
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
Sequence:
LNLVDQLGEADEELAGTYAELGDWCAQRILQHVQR
The following text describes a protein:
Function:
Catalyzes efficient strand joining on a single nicked DNA.
Sequence:
MKFYRTLLLFFASSFAFANSDLMLLHTYNNQPIEGWVMSEKLDGVRGYWNGKQLLTRQGQRLSPPAYFIKDFPPFAIDGELFSERNHFEEISTITKSFKGDGWEKLKLYVFDVPDAEGNLFERLAKLKAHLLEHPTTYIEIIEQIPVKDKTHLYQFLAQVENLQGEGVVVRNPNAPYERKRSSQILKLKTARGEECTVIAHHKGKGQFENVMGALTCKNHRGEFKIGSGFNLNERENPPPIGSVITYKYRGITNSGKPRFATYWREKK
The following text describes a protein:
Function:
Negatively regulates telomerase activity and participates in chromosome end protection. Binds RNA non-specifically. Associates with a regulatory Pol III-dependent lncRNA, which represses telomerase activity in response to DNA damage. Binds single-stranded telomeric DNA with weak affinity.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MEEERRDDYKFLRIQDAFKALHLHVNLIGVIVELGFSNGSDCSCTLKIVDPWYSGSGLPVKFVARTIRDLPRVESIGDIILLSRVKIVLINRKITALCNETTSSSFALFNGKHSVDSIPYQSSPKFLMREQDKNFLSNLREWMITYKFEDGSCCFTSLKDIKEGECSNLSCQIVHISKVYKDRWYLFVWDGTEMPPCNILVKSERLPLCVEPEMLPTYMLRKFPTFGSVLRIIVDRVSEKQAIHCLQPGQHVKLLNLFFQVNMGLWNATFTPSTKMQYTMSREMEAFSPQRMCGEKFSPRWNPIARCISRSHSEITGVAHDDAPFVSLMDILTYHNVTAKFRCVVRFIQVYPRDVRKLRDINGNIKLVAILEDATARIHASLYADEGEKFFGCDESDEEALVKKLNRLLGGEEMEKVPRNPPWVQCCLFSFYKHKMDQWESRRFRIFDTWINAS
The following text describes a protein:
Function:
Mediates the formation of endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) foci, thereby contributing to the formation of ER-mitochondrial contact sites.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type III membrane protein.
Sequence:
MLPNLRRIFASFRTEEEERSYSRKAFFHLIGYITCSVLFSWLVRKKVISSPVVSSPIHALS
The following text describes a protein:
Function:
Transcription factor required for the initiation of nectary development. Also involved in suppressing early radial growth of the gynoecium, in promoting its later elongation and in fusion of its carpels by regulating both cell division and expansion. Establishes the polar differentiation in the carpels by specifying abaxial cell fate in the ovary wall. Regulates both cell division and expansion.
Subcellular Localization:
Nucleus.
Sequence:
MNLEEKPTMTASRASPQAEHLYYVRCSICNTILAVGIPLKRMLDTVTVKCGHCGNLSFLTTTPPLQGHVSLTLQMQSFGGSDYKKGSSSSSSSSTSSDQPPSPSPPFVVKPPEKKQRLPSAYNRFMRDEIQRIKSANPEIPHREAFSAAAKNWAKYIPNSPTSITSGGHNMIHGLGFGEKK
The following text describes a protein:
Function:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the MRN complex, NBS1 acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (By similarity). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to DNA double-strand breaks (DSBs).
Domain:
The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AFX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage.
Sequence:
MVWGLFPVDPLSGEDKYYIFSKGIYKVGRKGCDIIINKDKGVSRIHAELTFDATTVSTSRRNKSSSDTSSFVIRVKDCSKYGTFVKTDLGTKDKVHELSNKEKILQDGDVIAFGTGSAIYRLSLIPLVFYLCPSSETFKVDQPVQDAVSSIGARISPTLSEECTHVLLEPRMQVNEALINAILAKKTIILTNWVMLLAEKSICSEIPGYSQYRPSVMVEEALVDVLELNVREKCLEGFTFVLEPTDTYRFGCSFPSLLEVCGAETVTIEDISSMSQDSQFGEINRMICVIPKSAGDKFGRFKHLSLLSRVNEMDLVCAVFSGNLPSTSLIPPSVVISSSCSTDETVVADSEAEEEETTSSVHMIDATEKAETPEKPAAIVIEDSPVTILEETSNLNEFKSVNLLADTESRGHMDEKNSSDSVTIRRDRNDEAETGKSEIIYTQDLIVRDLRSTRKVQSTGGEGVVDFKRFRKGNVTCGNSFSSLIPFAKDPYKEYDSWDVTDFMKEEKKRKQMEAIAEDLFKTEKARKRGTAGSIRGFLSGS
The following text describes a protein:
Function:
Probable tyrosine protein kinase which plays a role in vulva development, probably by acting as a negative regulator of the let-23/EGFR and let-60/ras pathway. Involved in the negative regulation of germline development.
Sequence:
MREEPTAGTADATLNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKMFPSGIFGKVKKAFKRAESLDRKTSNSVANQDDNDHHVIPIEKITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFPERRAQSVRAVVDCKDSAADHLHFKKDDLIVVISRSPAQYPDGYYWFGSLRNGKLGLFRPTDTVAHLGSEPPCSNGTIENGFSEKEKGGKKNKKAEKESERERKKLLISEPVGDVRHTCHVGIDGTAFGLLQLDKKAMCPTSSSPSTSRGSQASPAPSHTSSSTTSSVHLRETVARNGVPIKETMSLRDVGPLSRDALNLRDTVSPPVARAPSQPPSYSQPRPPPRSVSSVSSGNQHSVQVHDQFSSLDRSRGSLTPTAPPLTASAANSLKDPLTGISLSIPSNNLISYMDDQEDDHRWTRSPGAISQSTTLTALSSSRKDPIPAPRGPVAAVYARGKDIPTPASKSDIALCEKIEDLNRDLTNYSIGTICDYSEDRPLLDSMNRTISSSTTHQPPPQSSEARIRFMTEQEVRKINEKSAREHRKTEDLLREERQKEQKPGEIEEPQQPAESLYSTRTPQQEGWSSAAQEAYKLLVECGTNLKQASVSPPPMSPTSSRLSTLDRSSISPAPPRPVTPPLSVRNETISMRKSQQEEMEHVTVEENSPKRVHIIETKLIDGPARGMSPIQDRHIPAFTTPMSNGSFRKAPAPTPVSPAPAGSTDQKPPPCRPPKTRQFPLVIDERNLAYDNLNGFGAGARVAPPVPPKPKVRTIFSFADDQKKQKEVAN
The following text describes a protein:
Function:
Together with WIT2, required for the nuclear envelope docking of RANGAP proteins in root tips.
Subcellular Localization:
Nucleus envelope. Nucleus membrane; Single-pass membrane protein. Note=During cytokinesis, aggregates around nuclear pores at the cell plate.
Sequence:
METETEHDRTVSVDDNDSLVPEPSSTKESFFEDLSLTGQVMNPQLSSAGEVLTKVELDFAFVSEKLVNLSLLTMQLGTRENDFESFVSKKEEDEEEPSSNVDDDDDSAEKALEFDLLSSILNSEVKELESLLGFLQNEIQSARVMISPFQHDGEAFLDLEGKLNDTEQSLGQLMEQVVEMKKQSSNFQRLSSGLDEQGSWSGGQTSVSQNDGEFGDLSAKINMQTADQQRNVLRMLEKSLAKEMELEKKLSESRNTERELEMKLYSSEQDVVYMEEVTEDAFSRWLEADNAAEVFKGTSKEMSGKLQILQFNLSGSFKREDNLKSKLVDSKERLEAKECALHKLDSSNARLADFLVAQTEGLKESLQEAEEKLILLNTENSTLSEKVSSLEEQLNEYGIQTEDADATSGALITDLERINEELKDKLAKTEARAEETESKCKILEESKKELQDELGNFRDKGFTIHKLASLEKHLRDSDLQLEHAVAAVEASKEKQNLLYSTVSDMEDVIEDLKSKVLKAENRADITEEKLIMVSESNAEVNEELKFFKGRLKEGEKYLQQAEERKLRTAKDIGVHNKIMKKLVMQLAAERERLHKQITNLSRENCVLMVKLKKVGKTGYMESGNGSEVSPKSDQNASSCHQGSRLQATFISLTNPEEEETGSKSDIGSVRRLDVGALRFKHILVAILVILISSIAYVISQQNM
The following text describes a protein:
Function:
Increases glutamate release in the striatum and decreases GABA concentration in the striatum; Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release; Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted.
Sequence:
MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRESSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPMEPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEEEVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEALPSDEEGESYSKEVPEMEKRYGGFMRF
The following text describes a protein:
Function:
Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. May be involved in vesicle trafficking and protein sorting (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MDSVEGLALGPVIWTASQEELLRQPYNHLVTQPGKNFRNTLIRVFNGFYGLSERQVAAVTELVEMLHVASLLIDDIEDNSAWRRGVAAAHVVYGSPMTINTANYMYFVSMSLLGQLAAQRPAGPLQDLLKVFNEEMMNLHRGQGLDIYWRDTFTVPSEHDYLRMVMHKTGGLFRLTVRIMEALREGPDGPGSTLVPLSNLLGVLYQVRDDYLNLTDSRMSENKGFADDITEGKFSYPIIHGLQYARVHDPAGYDFLVSVLRQRTTDITTKRRVVRYLADVSGSLAYTKQRIIELATLIKTKYIPASGTELCNVIDSLTSF
The following text describes a protein:
Function:
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MNKLKHLFMCLLAIGTVRHNLPCFVSVHLIPVSTPKNGMSSKSRKRIMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEAFVSHMSKGSGASFESPLNSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLCHFCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERERREKKLYLGYSVLGAHPILNQTIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDREKPSEHSVRILYNGVDVTFHTSFCQDHHKRSPKPMCPLENLVRFVKRDMFVALGGSGTNYYDACHREEF
The following text describes a protein:
Function:
Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity). Partially localizes to dendrites in mature neurons (By similarity). Colocalizes with neurofilament (NF)-rich inclusions in spinal cord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).
Sequence:
MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLPRVMIPTAPHTEYIESSP
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWWRPRNVSDYERLIFKVWKYTGLPVFEIKRLGNSQTVIVHLYFYILLVLVCLGVINVSVFLIFCETKVDSYRIQMQIFLFAVVTCQNIFFTLFFYIRRNNVATLLTKFLTTEKIFLACFPKFGCLEVGAKLAKYLLIKVLYTLTMIIGDCLYLVKDRQDYLFRFCFFPQLVFFYVAEATLIFFVFLISKFYTEFGSSLKRNKQSLTKICSLYWAIRDLSRETNQTLQFVILLKFATDLFLMGNDLFFGTHYIMGMGLDNKFSFVYVFVIIVVWCVFILYVDITVTYVFDKNAEEEVHLIHSIEENVLNGEHFVPYKYDEILNIRSGLISPTYSLYGFVPLNCKAVYAMISSVVTYLVYLIQFTNHKYVL
The following text describes a protein:
Function:
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MAEMIEAKNLRNGQTIFGPNKEILLVLENTFNKTAMRQGIVKTKVKNLRTGAIVWLEFTGDKLEQVIIDKKKMNFLYKDGNNFVFMDQKDYSQIEINEKKLEWEKNFITEEIEVTVITYQDEILGVNLPDLVPIEVEFAEDAIQGNTANMARKKARLVTGYELDVPQFINTGDKIVIATVDGNYRERFNK
The following text describes a protein:
Function:
Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MTSLFKLVALLSLATTTSAFINGVNFGGLFILETSWMYDKFEAACEADFVAQLIKEDGLDYAIQTFRNHWNSYIPVELYDMLSVANISHVRLPVGFHTFDTPLTDFNTTMYNYGLSAEGFVTGGVNHVLEVVAELKDRGIKVILDVHAQIGGASKCSAYSGWSVANANESFWQGSPATNSASCASSGFYQSRRSSDKTYLEYGAEMVTETIVPFIVGLQQHSVYSDTIVGLELINEPGLSWNNLESEIQQYIMATAPSAHKQFSEAKLDVQLILNFISPNQDGMAAWVKAQQTSGALPAILIDYHNYYNWDGPLTMDEALARSCNATETDSRWSQYTDAGLPTFIGEWSTATNLGDPAFSDVDNATVAKFLSHLYANQVSVILNSKNVVGHCHWTARMGSGWDPRPTSADPNGRQDEGTSFKKSHPSFGNRLWNWAEMMDLGIFKPLFALDVTGRCACEGCQTHMSN
The following text describes a protein:
Function:
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, it acts jointly with DoxA in the conversion of 13-deoxycarminomycin and 13-deoxydaunorubicin to yield carminomycin and daunorubicin, respectively. In vitro, it also acts jointly with DoxA in the C-14 hydroxylation of daunorubicin to form doxorubicin, although this strain is not a doxorubicin producer.
Sequence:
MTRFAPGAPAWFDLGSPDVAASADFYTGLFGWTATVVSDPGAGGYTTFSSDGKLVAAVARHQIDTPYHRPYGPGNDQHGMPAIWTVYFATDDADALTKRVETAGGEVIMTPMDVLGLGRMAVFADPAGAAFAVWRKGVMEGAEVTGVPGSVGWVELVTDGIGAARDFYPATLGLAPADTGLKGVTDPVWHIGDTPVAGTQELGVTGAVRPHWAVLFAVHDCDATVRRAVELGGSVENEPADTPRGRRADLLDPHGAGFSVVELREGYPAAAGGAS
The following text describes a protein:
Function:
Inhibits DNA replication by binding to the DNA replication licensing factor cdt-1. Its interaction with cdt-1 prevents the cdt-1 loading of the mini-chromosome maintenance (MCM) complex onto DNA and therefore DNA replication licencing.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Mainly cytoplasmic, but can be re-localized to the nucleus.
Sequence:
MSRIGLQQLNNSARNSPFGSEKATGTKQIPEPLKLTAQLKKYQPITPSPLASATTITPVLSPFDVFCDDDQEAKNVETQMFEYGTVSTQTIINVPHVQPKITEADLTSEKPTVNYLRVMADRLQMDLDDEMDRNQRLVAELGDLDEKMRKIDDDTEILLEVLADIDEEQQTDEEIGTAQL
The following text describes a protein:
Function:
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits (By similarity).
Subcellular Localization:
Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle.
Sequence:
MSEAVEKIRSHDKYRQFYELATKIRNQKLLADAESASLHRHKQEVADLEVKLLTEAWRSSYWTNVSRQLKSQSLDPSYACRLLKEISDTEALAAYKHFGHHYSTLNQLLTVLYMEPTSVAELLNMWDQNDVTTNDNLIQTFFHLVYSCGLYPDDELKIAQVVCYLLKLQLVKSGSQMRTMLRKETSISTRFYKYFVEQMHPTMVYLTKALRKSVLNVIQLGNFWLDVDMKQSSSRFLSDGRQNSERLPEYRALVVSKLVDFVDNFLENISLALSMLPPNLNWIVRDIFCSLYEIVDDMSAIELSHACKDMIVSNLLCPAIISPQKFGVVDNDVRIGSIVNHNLAQIAMIIQMISLREFESPPEEYREFLSQCRNTHLISEMMDSLLVENMAPDVEITSLIASGKSESDLETKSNFVGSLADANKLIKMIRETPPTTDLKISRIVSVCQKMPESFASTVEKLHVENSEDSPKLSALRNIHRKVQKSFKRTGDSFYDPNELHMKTENYGGVFEKENFDRKLREASEVERRKQEARKQKQLKETELLIMDNISSDSAPITIKASAATNAPIANNNFTENKDLIDFSTLYTTTDDVISIPSEPSKEEKSVEKPNVNNVSVDAPVEALQIGESRGGLAKLKNFSDRMKKGITQSNTLSDIRDHLRRSSSLAKQPSGMVSSASAQNIPDTEKGDSILAKYASNSSIKIEKSTFTKLTDTKSMPKNTEMSEPYYSPENLTSCRAFKDTLRKMITVLGNVSYLPKIGCRSEMKEMSKKVRLDSFLDGVLVETEHRREYGQAAQLREVKRCIELFENEGVEILMDHLVGNEVEQDFLVRQMREERAILMRKSNDISSMEQRVLLNRRLTEQILVDNLIQTFLETGFQNSKLASGKTPEVVAVGKFYSEFKFLQAHDERAEFLQNLLTYLRERLMQNYDWNFATESMIARAMTTMERFVMFAVYEIAFWPNREMDQKKDKLLQSVIGKASSSVTPVHEALKIPEHLLGEAPWPSAQAELSMLDNYVTAQEKLNCLVRCCDVINNLVALSSKNAVASADDLTPVLVFVIIKANPRSLLSNLQFIETFAGDQIESGRDAYYWVNFKSAVEYIKTIL