lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Promotes the assembly and stability of microtubules.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Note=Localizes to the microtubules throughout mitosis.
Sequence:
MMADGAAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVATHSSNIRSTFKPVIDGSMLKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKRKTDKERSSSLNRRDSNLHSSTDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELRAVMFPMSTMKIPPQTKVEESPLEKVETPPKASVDAPPQVNVEVFCNTSMEASPKAGVGMAPEVSTDSFPVVSVDVSPVVSTYDSEMSMDASPELSIEALPKVDLETVPKVSIVASPEASLEAPPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPEAMVKASPKTSLEASMEASPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENACGLPSPISTNRQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTVKKKKETVSKTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKLKDGQQQNETKKKKGWLDQEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVNASKVTETSSHDIYEEAEADNEESDKDSLNEMFPSAILNGTGSPTKFKMPFNNAKKMTHKLVFLEDGTSQVRKEPKTYFNGDLKNFRQKSMKDTSIQEVVSRPSSKRMTSHTTKTRKADETNTTSRSSAQTKSEGFHDILPKSSDTFRQ
The following text describes a protein:
Function:
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Sequence:
MDTLTPKRRAIFEFIRERIAEHGQPPSLADIATRFGFASRSVARKHITALCQAGYIDVTPNQARGIRLAEPLRRPEILEIPVLGQVAAGAPIGPDLGIHEQLLLDPSLFRRTPDYLLKVRGDSMIDDGIFDGDLVGILQQADARDGQIVVARLDGEVTIKRLQRQGGTYRLLPRNPAYAPIDVQPEQDFFIEGVFCGLLRRD
The following text describes a protein:
Function:
Probable cell surface metalloreductase. May be involved in iron or copper homeostasis.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDEVVPRHGDHHNINIKYGYFIFALTIIQIIFFLQVKFIQIKRWNSTGRFSKFWSQLTNPPIWLMVTVWLLIVIFTGGHKISDFSEEYIISAKRYGRMAYCLIPLNIYLVLRPTNSPLLKPGYYLENMNLHKWTSRIIVFCSAIHATGYIYKWVKEGTILNKPFRFLNLLGVIVFVFLVVLAIISVRTFRKKIYSTFYLIHNITAWSMVILITFHARPGVTIFAVISILLLGYQLYLRYYSSYLVNSLKVIDIPTSTLQIIKIPQPNKFPNWLPGSHIRLNYTISKFKSWTTATHPFTIVTIPEDSANNLTLIVKKPNQFVVYPLDSYLLTGPYPSLAPPFFTTANIVNIICGGSGISLGLPIYHHFRSINSTVPVKLVWTVRNQNDTFIMNQLDMTGVQVYVTSIGDTNSESQENQQHQAVPLFVIEEEEEEEGHGLLNNESENGIELQNMPESNEENSETITINSKNNKDNEERKEYFKFGRPKFDEVFAIDDPTTTHDLDNSWVIACGPDELISDAKRWSKDRGYRFYYEKYEM
The following text describes a protein:
Function:
Confers resistance to chloramphenicol.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAAPAASDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
The following text describes a protein:
Function:
Probable E3 ubiquitin-protein ligase involved in the regulation of root growth. Acts as a positive regulator of root gravitropism.
Sequence:
MVFGWRKAFCTSVSSNQDKPQQHSSLHTTDPPIPTPRFRSKFGFLSNPSTPRLRSRGGSGTGCRSSASTSVTIPSLPTSPKLHCRTTSNATPRTSNSSSPKFFSNPSSPKSSSSSSSQGGGGVSLLRATLLLNKSNSSRCAICLQRVNSNQSNSTAAIFTAECSHSFHLSCVNGLEDKRCPFCSAAWNHAPKSNYPAVNNNFGSDPIRRPEIREIKTGKSLRVYNDDEPLAYSPVSLAQINTIHESDENDDVEDDDDFPGFFRDSSITSDMVPSISGNLEVKLLPESAVVETGKKKETHVVIMKLKASPSPSSITDAIKARRPSIDLVTVLDLSNGGANLQTVKHAMRSVISLLREMDRLSIVVFSTGSKRLMPLRRMTAKGRRSARRMVDALGGMETTGGVGMSVNDALKKAVKVVEDRREKNPSTSIFVLSDGQDQPEAVLKAKLNATRIPFVVSTTRFSRPEIPVHSVYIASPGALLHAPLRDAFTERIASLLNVTLHNVKLNLSLVNGSHLTEISSVYSLTGRLENFGSGSVIQVGDLFAEEEREFLVELKVPTSSSGSHQVMSVQSSIVDQMTHQPMTCPKEKRFLIPRPQSVRYVSSSIERLRNLHSMCRAVADSRRLIEREDLSGAYQVLTTARSNASHSDDSLRSLEVELNELSRIKPRNSILNRTEDKPEQLTPTSAWRAAEKLAKVAIMRKHLNRVSDMHGLENARF
The following text describes a protein:
Function:
Putative deacetylase.
Sequence:
MVSIMPKILYNPEVLGHKPKSYHVENPERVLTILNSLKSNGFDDIVLIEGKSTINEILEIHSRDYVYSIINLSKSFNYYDGDTYLCDRTLDAALTAFKLAKEAVKLALKDRDLYFALTRPPGHHAGISGRALGAMSNGFCIFNNIAGAARLAKNYMKKVIIIDFDVHHGNGTQEIFWNDNRVIHIDFHQRGIYPGTGDILDIGGEEAKGTKINLPFPAHSTDADYIFAWNEIVEPILNYFSPDTVLVSAGFDAFINDGLASMDLTETFYRFVGAKLSGYSVTAVLEGGYSIGLKYAPPAFLDGYVDAKDVLDNLEDYTVINSNEVKSMVKNVKKIIGEYLDIF
The following text describes a protein:
Function:
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular Localization:
Mitochondrion.
Sequence:
MTGRLHRARVLVSRSRYSTQPTRFNYLPDEYSQQEPTETQLVINQFSSSSTIKLLTTNELAKFNHPPRPSISLARDFIHDSLYNPNYGYFFNQVEILDRPETPTANFELDLYAEYFDPASGKQNNQLLLRRHLASESEDQPSSPADQRQIWHTPTELFKPWYAWSMAHYIVEKHLEKRDQLQEEGKELKIYEIGAGNGTLCVGILDYIKEHHPNLYEKTRYTTIELSRRLADRQREKIDRSGHQGRARVINRSILGLTSSPELEPSHEPCWVLGMEVLDNLARDVIRRDRVTGTPLQSIVITDQLGDFHERFIPITTQNNPNLLEYLDIFDQQQTKTTQLSLFFEKLWAKYLPFRSNLTQHQFIPTNYLILLQSIFNFFPNHRLILSDFSHLPNTLNDPRSNRFGAPVVQTRYNGVTVPTSTFLVKPGMFDIFFPTDFEELIHLYTHLLNTDHQQEADSSTHRLAKKVVGLDEQTQFLVKILASPSFRDKMSNINRRGHANVPDLDQISAYYHNVKVLTIT
The following text describes a protein:
Function:
Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
Sequence:
MTTPSDLNIYQLIDTQNGRVTPRIYTDPDIYQLELERIFGRCWLFLAHESQIPKPGDFFNTYMGEDAVVVVRQKDGSIKAFLNQCRHRAMRVSYADCGNTRAFTCPYHGWSYGINGELIDVPLEPRAYPQGLCKSHWGLNEVPCVESYKGLIFGNWDTSAPGLRDYLGDIAWYLDGMLDRREGGTEIVGGVQKWVINCNWKFPAEQFASDQYHALFSHASAVQVLGAKDDGSDKRLGDGQTARPVWETAKDALQFGQDGHGSGFFFTEKPDANVWVDGAVSSYYRETYAEAEQRLGEVRALRLAGHNNIFPTLSWLNGTATLRVWHPRGPDQVEVWAFCITDKAASDEVKAAFENSATRAFGPAGFLEQDDSENWCEIQKLLKGHRARNSKLCLEMGLGQEKRRDDGIPGITNYIFSETAARGMYQRWADLLSSESWQEVLDKTAAYQQEVMK
The following text describes a protein:
Function:
Involved in the malolactic fermentation (MLF) of wine, which results in a natural decrease in acidity and favorable changes in wine flavors. Catalyzes the decarboxylation of L-malate to L-lactate.
Sequence:
MTKTASEILNNPFLNKGTAFTKEERQALGLTGTLPSKVQTIDEQATQAYAQFKSKPSRLEQRIFLMNLFNENRTLFFHLMDEHVVEFMPIVYDPVVADSIEQYNELFLDPQNAAFVSVDAPEDIEATLKNAADGRDIRLVVVTDAEGILGMGDWGVNGVDIAIGKLMVYTAAAGIDPSQVLPVSIDAGTNNQKLLDDPLYLGNRHKCVSGEQYYDVIDKFVAAEQQLFPDSLLHFEDFGRDNAQVILDKYKDQIATFNDDIQGTGMVVLAGILGALNISKESIKDQKILSFGAGTAGMGIANQILDELMQAGLTEEEAKQHFYAVDKQGLLFDDTEGLTPAQKAFTRKRSEFSNADELTNLEAVVKAVHPTVMIGTSTQPGTFTESIIKEMAAHTERPIIFPLSNPTKLAEAKAEDLIKWTDGRALVATGIPADDVEYKGVTYQIGQGNNALMYPGLGFGLIASTAKVLNAETLSAACHALGGIVDTSKPGAAVLPPVAKITEFSQKLAEVVAQSVIDQKLNKEPIADAKQAVADMKWVPEYRAISK
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MGKKKERVPNVLWRRFRDKAATLSKTIISIIPKTCNCSGKGKCIRCIFGDGDEAAMSYLIRPNDSSDYRKLMNSCFVVVPENAPPLSPLLSFTRNWSQLQIVERTIQAIFSKEVAPSNVICQGYQKFKLQSTIVKVLTSWTWELASKRAGDSVMIYLLMHTLIFMPIKCNAHQQVAGPLVNRLFAGLPPDDVGPSMHASYPRKRRRGKGEISNAEEPASKVPCRVGQHNSFDLVGSKDVDYLGTHCSKESNLISENSSHEKYVLEEQPIEKLKVKSGKRFRLPSWQRRKRCKRLISQDCCTQEPSGKVLNTENDLHKTSDKSINVLDGVDLKSDQLMQVCPCCSVFQSLSRVPKDADINRKFTFYNLKSSSSLFLKKHILYFLKPGFVGDNDLLLHIFGLPNMGTRNLPTSCFHKLGLCSHGSSCLYHSLVKLLRVFIRRAKKCQHKKLLERHCSSQPRFQLNGDGDVGSSLQASKMDSKFSTSKQGVDQRTDQMPKRLIHAKSRDGKRTTEVTQCQFGLSQPYCLKDEVVSFIWSVCRNIVPSDLLGLPSSHRTLRRNISRFIRLRRFEKFSLKQCLHKLEVSKFPVLSKLESDKCCSAFAFKSETKKIPGQLPNSQNIGHGYLKQMLLERWIFWLFSHIVVPLIQANFYVTDSEQGKQNLYYYHKKAWKKLSGRVTTWLKEQSYRSLDNASVAEILSKRSFGFSNVRLCPKENGARPIANLKAASRFCIKRPFSQVQFRKKNRKRRAHKRYVPFLKSVNTVLRDLHVIFKDLKVKEPERWGSTVFSYNDIHRKYCAFLRHLKEGQPTMPMVYIVVSDVQKAFDTVKQDKLLSILNEIQIADEYSMQRSCEIFYRKKFLWISENRKLMIEGNNSRFTEDIPPVRQRTCQTIVVNQERSISVRRKELEFNLKEHLKKNVLKLGRCFFLQTVGIPQGSVLSTLLCTLYYGHMERNKIFPYLSLSGHDVTIRPENGCAAPEATSDVSFLSPKYLLLRFVDDFLFVSTSKKQASSFFSRLQRGFREYNCYMNQEKFCMNFDYGGTHKLDSKRLLVGSDGVSFMQWSGLLINSCTLEVQADYSRYLNDHLSSTLTVNWQHRPGRQLKTKLCAYMRPKCHSIFFDSSINSPATIRLNVYQAFMVCAMKFHCYVRALSYWCKLRSGSCLSSIEGSIRYMYKLMKRRMHKVNFAPERNRVLQVAKTEVIWIGLTAYIRVLSKKKSRHNELLHLLRTKLEAVSNVRISSGLKYAVDESHSSYLWKIKY
The following text describes a protein:
Function:
Functions as a component of the nuclear pore complex (NPC).
Subcellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane.
Sequence:
MSVSPEPERAREFRAGDSVVPFEGWRGADGGQRTPGNAAPWHGDDHKEAPSQQGTARKTSSEVAVVRHRDGAQHQSSRNASKHRVRSDNAPEAYAALLRPALRGDAEFASVLGGLHDLAQDLADRRGEMAAAQTRSIERHLLEHKSRVLQSEAATWSLVWHLLGKPLQEMLSAGLLPPTSQQEACEYALQDARAQACMRVVQWLEDLAGQQVDRDEKRHGGYAGLLRHSQGVWVRTAQALKSSQRPPSNLVSHVDPDAPTRENLRLHPQDSEDEELLMRGVWTLLKAGRLSDARQLCRDVGQAWRAASLGGTGDAGPVPSVEGFRGLTGTKRAREEQAAEIEAGRGRQRRLWKWTCFLASEKVGGEGGESKYEAAVYGALSANTSKMLPVCDTWEAACWALFRGWLDSQVDSALADAHAAEGLTGPSPSPDELSGSQEKRSAIAEAYKNSSAAGGWPAPVLAQQPQSFPEVFERLQTSPQLPDSVQRAGKDQQRMIQTLIILHRWGELVDCLKHWVVTPTAETGRPRSQPEFIRFAAHLVLALRKVLPPDEDLFQEDLQRTCNVIINMYAVQLVAEQQEHLVALYAAQLVAFARVDLYANLLDMKQGAGLEVKQRIFEGALQELDFSGEGSVCQILDRVLVESRADQDPPEGVPAAEHLSLEAFRRTRAMDWLFLPVPVQWAECRPELTAKALLHGNIILRELALASAQDWSPAAPGTARAAAGLLEHLSDAALSPTEELAAVRMVDADTLEAALLEKREWERYFRCDGLLRRWALLDEANRRIGAGQLTPEEAHEARQLAEQAIQGVQEILDGWLSEAELDAPSPVGVTSEEVEMTAALVGKDGKLEPAGRAECSAVHDAIMALVEEGAAEGNDIQVNVNPLPGNTGLLKLRASRDVSEHGDADGAVLVRLLAAAVSGGLPPPAHQLLLRPSRIDARFLFGGDVGPVEAPPLLRSLCRHCCIPSLALRAMHARIYLAGFEGFRIDEAATDVVQVIATRGAAELFAQEQLQEILHLEREATLRSMDRKERFSQRE
The following text describes a protein:
Function:
Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus.
Sequence:
MHVSLAEALEVRGGPLQEEEVWAVLNQSAESLHELLRRGSADPTALGFIISPWSLLLMPSGNISFTDENVTQKDLRAFTPPEVLDGLNLSSLSDMEKMHMYSLGMTLFWGADYEIPQSQPMELGEHLNSVLLNMCDDSTLTRLSVRSVLDTCSAHIRTSNCDPSFSYVRRLVRLVLGSLSQLDGLLSQTERESIPERSKEIRERLRGKGLPSGRSAAHRVLERYRARTQEQANLNRGLSRSMGSLPMQDLIHANEGLTPYPPPDYPTASELPVELYHQRQQQQLQQQRGRPIEVNQRLHPHQRNKSWASSADLACLDPDMLRFGALEDARRGSSALSTRSAGRHKPSSKARDSRYSEFGSLDVRKTHHHSNQSVGSAFNSAYDRIREKQKKLQALKQAIDDPHTHRRYNSDYSSSSESPSVTSSDPDYRQAKKSEDLRRFSSQVGLSDHDGVSLSGSQRHRLFEGGQDELSGTELLIQRQEELHRLQARMSRASVYPGEDLAEPLHSSPVEAGLHPRKSKNLFGPEFVRMSSEPTVVLTVPSSIMNKRGKVEESQRKVGVVLLNGQKLELCCDVKAVCKDVLDMVVAHIGLVEHHLFSLAYLKDDEFYFVESDAKLSKVAPDGWKDDPKKKKTDVIFNLFLRIKFFQDDVSLIQHTMTKHQYYLQLRKDILEERVRCDLENAMILASLALQAEFGDYQTELHGKTYFRTEHYLPAPVLDKIDQTTIKEELPKLHSSYYNASEQEAELEFLKVCQRLPEYGVHFHRVLPEKRSLTGIMLGIYSKGVLIFEVLNGNRTPVLRFPWRDTKKISFTKKKICLQNTSDGIKHLFQTDSQKTCQYLLQLCSAQYKFHLHMKARQNNQELQELENSPLSSLQYSDGMGAVSLSPSSEPELYKRMSYSEMSLSKSSSSRVSVPSEPPYPGFSSSSNPRMKSRSHHNLGQLPESPEHRMVPFSSQSQSSMARSQVLASSHQRANSDTGSIAVARQQESLSVDDSPRWSPKSLKKESDSSSCEDTGQAYVVGVSMHSSGVPSTPASSIGITDSLKKKVQALPSPEREIQTVNLKKDVKYGLGFQVVGGESSGRQDLGTFISSITPGGPADLNGLLKPGDRLLSVNDVSLESLSHTTVVEMLQSAPDDVSLVVSQPKERLFPDSPSGAHHYNPATQIQELDMDSSSEDHTRSPSPPFTASKTSPPQSIRQGSISSQDSKTESAGLQQTHLNGFHKNIPMEGPVAAQALPADIKPSIEAMPPALPPKTRKAKAADVPKELEYSDRGDSDMDEDTYSNSQDKLKTKKGVSPITITETLSASSPDVNSLHPGDLFDIELSKIDSSLGISVTVLFGKGGSNTSLKHGGIYVKGVIPKGAAEQDGRIKKGDRVVAVNGKSLEGATHKQAVEMLRDTGQVVHLLMERGQPPKDSIHAPLTPQGTSEPQNKTVEEPSAPEKEYNFITADNTFDVALLKNTSGLGFSFSREEIIPGEPLGSSMVRVKKLFPGQPAAESGRIKVGDVILRVNQTPLKGLSQHEVISALRGTGQEVTLHLCRPEQGILPEMDTAITTPVPSPRKQAHLQPQASPRTSSSPQESQRLLGPVEEALERLLLKSPSRRDSYSDSTDNDELEEAFRAANLERDSSAYQTPAERVSYEDEMDDTVQSAYYSSRQSMARSEDSRSDVNSSSIRISASPALPEGDLLNPSPDPLPPPLPNPVNLSLPEHEDLIPEVELKVSLVKSDKGSLGFTLTKGTDENCYIHDIIQDPAKGDGRLRPGDRMIMVNNTDVSGMNHTEVVNLVRAAPKVVDLVVGRILEPPKPPIEAHLLPDITFQCHDESLGLVLDGGSDSALGVLYVKEIFPGSAAFEEGSLRHLDIIHYINGVPTQDLTLSESRRLLQLSLRNLSLKATRDGKPVFPDEEEISLLNNNISPKVSQSMNGYLHSSENNELEALSGICPAEEQIVKLELEKPPAGGLGFSVIGGERGIFVKSVTPGGTADIAGTLQVGDRLLKVNDDLMIGVSHAKAVTTIRKAKGLVQLIVSRPPDQMPNTYLGFLPLKSSTVNGNNDVSEDSGVKTKLQTPSEQSQSSSPPPLPPIDYDTGSLEKRKGTDTSADLSEDTDCDGSSLPEDSPETSRKAEWKEENVDAPLNDSAPQSSSGPLDEDEITWGSDDLPIENINSKFTEDGPIVTEEELTSLPLVKVVPDGHYTSTNLNTIVRMMRGLIEQKVPLQEFENLQNLRPLDECLIGQTKENKKKNRYKNIVPFDTTRVLLGNDGGYINANFIKMAVKDESFMYIACQGPLPTTLGDFWQMVWEQKSNVIAMMTQEVEGGKVKCQRYWPDTPRSPQMVDDRLQVTLVKDQHLDNFVIRLIELKDVQTNELQRVTHLNYTGWPDHGTPTQPEQLLTFISYMRHIHLSGPIITHCSAGIGRSGTLICIDVVLGLISKDADFDISDIVRTMRLQRQGMVQTEEQYIFCYQVILYVLRCLQAEEELSG
The following text describes a protein:
Function:
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MDNSDRPLTAKEKRQEQLKRWENSATDSESSILNNYKPKVKFHDGAVFLAACSSGDLDEVQALLDKGADINFANVDGLTALHQACIDDNLDVVEFLVEHGTDIDQEDNEGWTPLHAAASCGFMDIARYLVDNHANVAAVNSEGEVPLDIAEEDDMVEFLQKQIDNQGLDIEAARNEEQEIMIADAKQHLNSIHNGDQSSIYRHPKSGATALHVAAAKGYIDVIRLLLQSGMDVNLRDNDGWTPLHAASHWSQQEAAKLLSDRGANFLSRSNLGQTPCDVADEDMLEYMRELQKENINVLLNKVERFEIHQQIDIHETKREFNEVHDNDVGVAHISAAEKAFNRDTLMSSSSDSEDDSTSSSEVTSSKLTEKQSKLDNDFITDKIGSRTDIQDTSSLTYSSSGSNVRSTTGFAGRRVTRPASLHKSNGPDAAVVTPTERNSDIKDGAPSTWRLGLRKTGSFDEKMRMGRPPTGSASRGSQNDIDRSASYNVSKTQEEQKSSKSETRTARVAPIIDARLPSSKSRNTSADENEPASSFQRSGSYRRYANESTSTFSTATPISYKRSISYKRAVGRTSSSDIKDSIEQPSKHINPTCNYGWQLASCHKTWIACQHSCSSPHKPSNRLHRSRSLDLPSNEADQISNLIRLRYQKLVNKYREPDASNKPNEATRYQSWFAAFVEEAADTSEQTNAAIDIRPDRRRSHLQPVRDEEAEAQRKARSRRERQTRRSTQGVTLDVFEEAKRTIDHMKQERSENASSSVSKQTDASDDSMATNHRRFNSSASSSSNSPRTVTLPSGYIPSNERVRNTANNFTQPHQMTIFMWSTYELCHNKDDDNADEGNSLTPGGQSPSARKSAAQQRRRQRKERRSTGLPGLKPSETTNTDNQSDDEETFKNDTELNKAERLKSTAARYDSSSLPDRHTRHRAGIRGSDNDLPSRFAIPVDDRKTDDKDYKKMYQDSRDENDRLQSELAEAKRRVTELEARLERADDVTARRKAVESEKRSLEKKLAEAEKELMVMADLKSDNQRLKDENGALIRVISKLSK
The following text describes a protein:
Function:
Required for maturation of 30S ribosomal subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDSDDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVYIKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF
The following text describes a protein:
Function:
Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (By similarity). Plays a role in the late phase response of TLR-induced immune effector expression. Strong transcriptional coactivator (By similarity).
Subcellular Localization:
Nucleus. Nucleus, nucleolus.
Sequence:
MGGLKRKHSDLEEEEEEEKWDWSPTALRSYQQALLRISLDKVQRSLGPRAPSLRRHVLIHNTLQQLQAAIRLAPAPALPPEPLFLGEEDFSLSTTIGSILRELDTSMDEMEPPLNPAASSSPQNEIVSQADPVFLEALSSRYLGDSGLDDFFLDIDTSAVEKDVALPPPEPPHSLFCSPGSWEWNELDHIMEIILGS
The following text describes a protein:
Function:
Inhibits the activity of the calcium ATPases ATP2A2/SERCA2 and ATP2A3/SERCA3 by decreasing their apparent affinity for Ca(2+).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MGQMVPPRSIQNEDFWKNPWDVGGLTVIGLFTSTFLLFVLFAVVFGYVEKAVFEEE
The following text describes a protein:
Function:
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
Subcellular Localization:
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
Sequence:
XKLEENLPILQQPTEKVLADTKELVSSKVSGAQEMVSSAKDTVATQLSEAVDATRGAVQSGVDKTKSVVTGGVQSVMGSRLGQMVLSGVDTVLGKSEEWADNHLPLTDAELARIATSLDGFDVASVQQQRQEQSYFMETVKQGVDQKLVEGQEKLHQMWLSWNQKQLQGPEKEPPKPEQVESRALTMFRDIAQQLQATCTSLGSSIQGLPTNVKDQVQQARRQVEDLQATFSSIHSFQDLSSSILAQSRERVASAREALDHMVEYVAQNTPVTWLVGPFAPGITEKAPEEKK
The following text describes a protein:
Function:
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
Miscellaneous:
MISCELLANEOUS: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
Domain:
Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.
Sequence:
MTLWVLGLNHQTAPVDLRERAAFAGDALPRALDSLRILPQVREAALLSTCNRTELYAMADDPQTLVAWLDMHAPGLSGYLYQHRDAEAVRHLFRVATGLDSMVLGEPQILGQVKDAWAVARAHGALGSGLDRLFQQTFSVAKRARTDTRVGANPVSVASTAVRLAQESFARLNESTVLLVGAGETIELAAKHLSEGRVRRLLIANRTLAHAQTLATQHGGVALPLTELDRHLAEADVVFSATAAREPVVTRVQVEQALRTRKRKPMLLFDLAVPRDIEASVAELSDAYLYTVDDLERAVEDNRRSRREAADQAEAIIDLQVARYVETLQANERQAPLKRLRAFGDSTRDELLAKARQQLSNGKPADEVLEQLAHALTNRLLHPPTAALRDAALNNDLDLTSAADRLFPEKPGYRHPPVATPIVRTDDANPAP
The following text describes a protein:
Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE; this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.
Miscellaneous:
MISCELLANEOUS: The four proteins YwlC, TsaD, TsaB and TsaE are necessary and sufficient for tRNA(NNU) t(6)A37 threonylcarbamoyladenosine biosynthesis in vitro in B.subtilis.
Subcellular Localization:
Cytoplasm.
Sequence:
MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVHSLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAANGRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLFLGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLAEAEAKWIESQK
The following text describes a protein:
Function:
Critical for defining the anterior-posterior and dorsal-ventral axes of the egg. May signal directly to dorsal follicle cells through the receptor torpedo (top). During oogenesis this signaling pathway instructs follicle cells to follow a dorsal pathway of development rather than the default ventral pathway.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Associates with the membranous cortex of yolk granules. Transiently inserted into the cell membrane, and then reinternalized during yolk uptake. cni is required for its transport to the oocyte cell membrane.
Sequence:
MMQIPFTRIFKVIFVLSTIVAVTDCCSSRILLLREHTLKIVQHQHSHMHEHAHELQQQIQETAVELLNRLELQRKQLEASAQEEADQLHPDTDPNPDSGGQLPNADDSIAADPEQDGIILGSSTDTWLASESSTPITDSETVTTPETVTHTGEPPPDPSSSSTPDSTTPSPNDKETEIQMLPCSEAYNTSFCLNGGHCFQHPMVNNTVFHSCLCVNDYDGERCAYKSWNGDYIYSPPTAQRKVRMAHIVFSFPVLLMLSSLYVLFAAVFMLRNVPDYRRKQQQLHLHKQRFFVRC
The following text describes a protein:
Function:
Plays a role in protein trafficking, actin organization and embryonic morphogenesis. Potentially acts as a cdc-42 effector. May play a role in egg laying. Together with toca-1, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14. Also, together with toca-2, controls the distribution of actin at cell junctions.
Subcellular Localization:
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Recycling endosome. Note=Diffuse cytoplasmic localization. Localizes to the rachis, which is the central core of the cytoplasm connecting developing oocytes in the syncytial gonad. Co-localizes with toca-1 on recycling endosomes.
Sequence:
MIPVSRFFTVQDPSNALLSYTQKGIDFFEKLGQFSKEKAAIEEEYSTKLRSLAKKYAKKSEEDDEILKSVSYTSSFNSFLQQLDQIATRHQTSAEHIRGGVVSYVASKTCQMRSSRKNAINDLKTINDKLEDQINEMCKSGKCYLKSFKDAENSYQKFYKADKNLEISRLELEKARALANARNEACELAKQDYSALVRKTNAEQKRYHVELLPVIFARLKAVDKECIADMRQVLQKIVSFDDSLADSTEECRKIMQREVGKIDAEGDAQLVLKSVEATIEQPAPFEIEDLGDPKNCDSRTNDSADGSGGKLLKSSPSKNRIIRNFLGILKEKEADEKPEASNNDQLMYTDKSKPAHVRLSCLRSKIRDMEKQLEQAIQGREGITRLQQAYYTNPQHGNPSACTEPLISYAKKIEKLKMDIHNLKEFYAMLEMSVEEGQERSFGGRDTPDTTRSMSGSSTNQSSSKTIEDVLSGEAGNSSSADDSSKNILRQLFTTPKRLISSPKTSKSSTPTPLRRRAEISSPKILRSSFSGAIRKSLSTPDSVKVETAVTVTALFEFAKSSAETMSIEQGEILLVLEHDHGDGWTRTKNCRKHNEESGFVPTSYLQFPQ
The following text describes a protein:
Function:
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MEHQALQLTQPPYIFGLPCQISRDDDVSWCANRTFKILLKNINSTKEVTHRIGAMPQELALAVPVTTRMVLNPKIEGKDDESDGWLLDRCIPTVKPSSASLCNQKKSLRVRSQAQGMIATSAFIIWKALMFVTGTESPIVVVLSASMGPGFKWVTGLISPFFLVSFPVILGLSPTFFCLLKNCVILIVHRAIKVHERENAEEEDDVLTKGAGSAEEARNNSKGGMCRCCTLLLFNLLAVWLKDFITSTHRYR
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MRALGLLSSGTLLTLDEWEIPRERIVINRKLGEGAFGTVYGGEAFFDDKGWVAVAVKTLKVGSTVEEKLDFLSEAEMMKRFNHKNIVRLLGVCTRNEPVYTVMEFILYGDLKTYLLARRHLVYEKSREDSDEISGRRLTSIALDVAKALSYLAELKYVHRDVACRNCLVNSNRVAKLADFGMARPMYENDYYRFHRKGMLPVRWMAPESLVDGLFTPMTDIWSYGVLLYEIITFGSFPFQGMSNNQVLGHIKNGMTIDIPEGVKPQLETLLKSCWHRTPSLRPQAAEVVELLTNNTRLIQPCVGIPLSSIQIEGSASLELQLPAAVTVHGCQVRKSNSGGNNKLGSSSLASKLASLDLSLGSGGGSANNSDSLLCDPLLMNPYPASHFVTQYITLQHRTSGEQIYIAETRENGSSQV
The following text describes a protein:
Function:
Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.
Subcellular Localization:
Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MTVQKLVATAVLVALVSLVLNNAAAFTPNWVYQALDDGRKRSVGLWKSCWLAERGRAAAGGAGAGPGHGEERECEALSWGSESAGFQESRSTVKLQFDMMRACNLIATVALTAGQLIFVLGLLDLPFVSQDTQWWEEAIAALFQLASFVLVIGLVTFYRIGPYTNLSWSCYLNIGACLLATLAAAILIWNILHRREDCMAPRVIVISRTLTARFRRGLDNDYVESPC
The following text describes a protein:
Function:
May play a role in the plastid ribosome biogenesis.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MDNGGSVLSLSAPHFPYSATILRRHSPVASISFSLKQPPPQPPEPPESPPDLRRPEKSIGSSSSSSSPSPIPSPKTPLKINPLKGLTNRSSVSPLVQSEVSSKVSSFGSSLASKLRLSSKLSPPPPPPPPPPVEETTQFRDEFRSDTKPPEEETRNPQQEFRQEGKIFVGNLPTWIKKPEFEEFFRQFGPIENVILIKGHHEVEKNAGFGFIIYAAEKSAMKAVEFDGVEFHGRILTVKLDDGKRLKTKAEQRVRWVEEGEEDTKMSNKSSWHQEREGSRKSLQRILDTNGDNWQAVISAFEKISKPSRTEFGLMVKFYGRRGDMHRARETFERMRARGITPTSRIYTSLIHAYAVGRDMDEALSCVRKMKEEGIEMSLVTYSVIVGGFSKAGHAEAADYWFDEAKRIHKTLNASIYGKIIYAHCQTCNMERAEALVREMEEEGIDAPIAIYHTMMDGYTMVADEKKGLVVFKRLKECGFTPTVVTYGCLINLYTKVGKISKALEVSRVMKEEGVKHNLKTYSMMINGFVKLKDWANAFAVFEDMVKEGMKPDVILYNNIISAFCGMGNMDRAIQTVKEMQKLRHRPTTRTFMPIIHGYAKSGDMRRSLEVFDMMRRCGCVPTVHTFNGLINGLVEKRQMEKAVEILDEMTLAGVSANEHTYTKIMQGYASVGDTGKAFEYFTRLQNEGLDVDIFTYEALLKACCKSGRMQSALAVTKEMSARNIPRNSFVYNILIDGWARRGDVWEAADLIQQMKKEGVKPDIHTYTSFISACSKAGDMNRATQTIEEMEALGVKPNIKTYTTLIKGWARASLPEKALSCYEEMKAMGIKPDKAVYHCLLTSLLSRASIAEAYIYSGVMTICKEMVEAGLIVDMGTAVHWSKCLCKIEASGGELTETLQKTFPPDWSSHHHHHGFLDQVSDVDSDEDDVDGEDGEDDEDVNSVSDLLSPYK
The following text describes a protein:
Function:
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
Subcellular Localization:
Mitochondrion matrix. Peroxisome.
Sequence:
MATVRKGLPRRLAGLASLRAVSTSSVGTFPKRVKIVEVGPRDGLQNEKNIVPTAMKIKLIDMLSEAGLPVIEATSFVSPKWVPQMADHTEVLKGIQKFPGINYPVLTPNFKGFQAAVAAGAKEVAVFGAASELFTKKNINCSIEESIQRFGEVLKAARAASIPVRGYVSCALGCPYEGKISPAKVAEVTKKMYSMGCYEISLGDTIGVGTPGGMKDMLSAVMQEVPVAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLLEAGTFICQALNRKTSSKVAQATCKL