lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MTEFRAVVFAAGRGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQHNFSEVIVVVLEQEKLEIQSALENTPLKLRLDYATIPSDGDFGTADSLRYIYDKIKSDFLVVSCDLVSNVSLYPLINKFREHDAALAMLLFPSGFESDVVMPGPKSKHKPERDLIGIHAATQRLAFVSAASDCEETLNIQRHLLKNRGRLDVYSRLVDAHVYVLKKWVIDYLRRKENISTFKGEFLPHLIKKQHSKRPPKTVQDTTSEVGVVTKNEDHVLHYVGHTILDQKITQTSLFNQSLSQSPYHGDIVRCYGIQAPRDAIGVRVNNTLSFLAINRKLASIWNNLCGEKHPLISPGAVVKSTQTKEIIAADNAKLSEKTSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNIDNCIIGHRAQVKSGSVLKNCIIGPNYVVEEGTHSQAVHLSNADQFMEIDIQ
The following text describes a protein:
Function:
May act as repressor of root growth during copper excess and of hypocotyl growth in the dark.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MFVMSSSSIPNGIFIIDGQERYVNPEGDVESNKSERTSKASMVFQMCEKQCRDENGFKCHCMSESHQRQMQVLGQNPTRVVNGYSQEFEQTFLDLMRRSHRFSRVAATVVYNEYINDRLHVHMNSTKWATLTEFIKYLGKTAEEEKQEREIQKQIERASAGCEGKDVVVDDDDNDDDEKKKDEDFRLKKVGFALGLGVKERGESSKLVFGDEENDKVERGDKRKRSALDELMKEEEKKKERMNRKDYWLFEGIIVKGVVKRVIDKYVGEIEMLESKHVLRVDQVELKTVLPQIGGMVKIVNGAYRGSNTRLLDLDTEKFCAKVQIEKGVYDGRVIKSIEYEDICKLA
The following text describes a protein:
Function:
Mediates sugar transport across membranes.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MEAGGLADSLLSGACVLFTLGMFSTGLSDLKHMRMTRSVDSVQFLPFLTTDANNLGWLSYGALKGNGTLIVVNAVGAVLQTLYILVYLHYCHRKGAVLLQTATLLVVLVLGFGYFCLLVPDLETRLQQLGLFCSIFTISMYLSPLADLAKVIQTKSTQRLSFSLTIATLLTSASWTLYGFRIEDPYIVVPNLPGILTSLIRLWLFWKYPPGARQELSASANLREFI
The following text describes a protein:
Function:
Orphan nuclear receptor.
Subcellular Localization:
Nucleus.
Sequence:
MEQSKMNVKPQPLVSACLVCGDPNIQRHYGTVSCNGCKGFFRRSIWEKRTYKCSFHNQCSIEHKYRNRCRACRLEKCFRAGMDASAIRNKRAKRKSQPESPCTEEIENRALSWQTEAIIALLMQKNGQTHNKLSQFSGASEFNFSTRSFVTLETLHLNRHQLPNRIWLENTLPEYQMLVHADKNVLMSLSILSVCWLTSAFESYKFECDGILFADGSWFPRDRKLRSQVCSRCVTYFGCTVDLFLTQVVYRIKELKIDETEITLLKAICHLQPSPQLSRHAIEIVANGQTKYKKVLCEYIRSNTDGYMDASIRLCKILQILPELDALAKLEEDNGLLVSLSGIELNAARQEVLPGNSLMAVLI
The following text describes a protein:
Function:
Cleaves DNA cruciform and Y-structures as well as heteroduplex loops. Resolves Holliday junctions, recognizes a broad spectrum of DNA substrates ranging from branched DNAs to single base mismatches.
Sequence:
MLLTGKLYKEEKQKFYDAQNGKCLICQRELNPDVQANHLDHDHELNGPKAGKVRGLLCNLCNAAEGQMKHKFNRSGLKGQGVDYLEWLENLLTYLKSDYTQNNIHPNFVGDKSKEFSRLGKEEMMAEMLQRGFEYNESDTKTQLIASFKKQLRKSLK
The following text describes a protein:
Function:
Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.
Sequence:
MMSPHKTHTWLPLAVAALLLILGPQSSLAEEPIYRLCVPQIYLAECQQLLADPSEAGIRMECVAGRDRVDCLELIEQRKADVLATEPEDMYIAYHRKNEDYRVISEIRTQQDKDAAFRYEGIILVKKDSPIRTLQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSADPQISATERELKSLSEFFTQSCLVGTYSTHPETDRLLKKKYANLCALCEKPEQCNYPDKFSGYDGAIRCLDKGQGEVAFSKVQYIKKYFGLPGAGPDAPPAEGNPENFEYLCEDGTRRPVTGPACSWAQRPWSGYISNEQAVHNSEQLHQLQSRLERFFANGLQAQNKDAAAHLLIQPNAVYHSKDAAIDPKVYLERAGYKDVIERDGSAIRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQSTDCVVALTKKEADLTIVRATGYADARSNQLQPIVYEQRAQDDVLVAVAAPGVTREALQKASIKFNENCERSRAAAALLNKRRGLDACRVSSSDDGEVQIVPASELEKHKDAQLVCPSLERRPVTDFRDCNVDVQLPRAIFIRSDTTSVEQETVKHLFSLISDKFGARGKLVDVFALFGEFQKGKKNVYFNDKAVQLTTELKNEIQNEQIYTDLQCNANKIAKQ
The following text describes a protein:
Function:
BMP antagonist which may play a role in neural development. Promotes cell adhesion.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane. Synapse.
Sequence:
MPSSSAMAVGALSSSLLVTCCLMVALCSPSIPLEKLAQAPEQPGQEKREHASRDSPGRVSELGRASRDEGSSARDWKSKGSRALSGREAWSKQKQAWAAQGGSAKAADWQVRPRGDTPQGEPPAAAQEAISLELVPTPELPEEYAYPDYRGKGCVDESGFVYAIGEKFAPGPSACPCLCTEEGPLCAQPECPRLHPRCIHVDNSQCCPQCKEKKNYCEFRGKTYQTLEEFVVSPCERCRCEANGEVLCTVSACPQTECVDPVYEPDQCCPICKNGPNCFAETAVIPAGREVKTDECTICHCTYEEGTWRIERQAMCTRHECRQM
The following text describes a protein:
Function:
Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, kanamycin, tobramycin and netilmicin.
Sequence:
MNIMPVSESLMADWLGLRKLLWPDHDEAHLQEMQRLLQQTQSLQLLAYSDTQQAIAMLEASIRYEYVNGTQTSPVAFLEGIYVLPDYRRSGIATHLVQQVEAWAKPFGCIEFASDAALDNRISHAMHQALGFHETERVVYFKKHIG
The following text describes a protein:
Function:
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Subcellular Localization:
Lipid droplet. Membrane; Multi-pass membrane protein.
Sequence:
MANLKLVPHANPQLSILHARVNTPKLHISMKHHRHYFNPTLRSQQQQPQHVQVHATTTHTPQHHGGEALLAGVPLGAMLLLLSGISLIASLLGLAVATPLFIFFSPLLVPAAFAIGMAVTAVLAAGACGLAGLVLFSWVVNYLRQMPRGTTMMTVLPEQAKRHVADMAEYVGQKTKEVGQDIQTRAHHAQGTTRMTVH
The following text describes a protein:
Function:
Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
Sequence:
MQHGSHCTVVYDGKTLHGQADIPLIEFLSGHGIDLSHICYHPALGAPQTCDVCWVEVGGELVRGCTLRSHDGLEVSSTVERAHAARHEGMDRVLAKHELYCTLCEHNTGDCTLHNTFADMKMPIQRYAFQRKPYEKDHSNPFYTYDPDQCILCGRCVEACQKVEVNETLSIDFSMEHPRVLWDGGKPINASSCVSCGHCVTVCPCNALLEKTMQPDAGPLTALPQELKRPMIDMVKTLENTIGAPPITGVSVLDMHWRQPEIKRTKTVCTYCGVGCSFEMWTRDRHLLKVQPVVDAPANGISTCVKGKFAWDFVNDPKRLTTPLIREHGRFREASWDEALALVARRLLEIRDLHGAQSIGFIGSSKASNEEAYLTQKIARLIIGTNSVDNSSRYCQNPATEGLFRTVGYGGDAGTIADLQQAELVVIVGSNLAENHPVIASKLKAARKLHGQKLIVVDPRKHEMAERADLFLRPVPSTDIVWASALSRYMFDNGYADTQFLAQRVNQVDEYRQSLEPFTLDYAAQITGLSREQLVEAGEMIGRARSVCIVWAMGITQHTHGADTSTALSNLLLVTGNYGRPGTGGYPMRGHNNVQGASDFGCLKNMYPGYESVSDPAVRNKWAQAWHVPAEQLSLEVGSDNFMMVQQADKGEIRAMYVIGEETAFSDADARNVHRGFSKLDFMVVQDLFFSRTAEFADVVLPACPSVEKDGTFVNTERRIQRFHQVFPPLGQSRPDWQILTELAARMGHDWGYTHPSQIMDEVARIATLFKGVSYQRLEGWRSLLWPMQDDGRDTPLLYTERFHTDDGKARLHPLQWKRPGEEADAQFDLMLDNGRMLEQFQGMNQTGRGPRLWSLAPNWFVEVSPQLAAERGLQEGDWVKLSSRRGSLEVPVVITDRVAGNTLFLPIHQGKPGINLLTGEHHDPDVNTPAYKELAVRMEPLGRTGKPPLPAHNFRHGHRTPNDGVPVQQKWAREDYVAPPARAPHPERF
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MEKVKLTKNLKLKIKNAQLTKAAGLDKLKQKLAQAGSSDTKNSPASKAQTKEKSSKKTAGTPAPAPEVDSGATESTARRIRAKDRSSFAAEPTVTTALPGDASHLTLDAIPAMKAPEITSVTQKEQTLGECTDTSSVQQEEKKESSEETSPERVEETLIIRTRTEPKSVVSIKPKFGPTGKHINHLLAKTFKAPAKETKAASTEETTQQQPRQNDAASYNNKQQPSGTSSRPASSAPSYRRESTNNNNNAKRGSERDRSKRSDESVKAFTGRDRYGLNEGSSEEDKWRKKRVHKTKKQAEEHVVQCPAHIKIALPITVKDLAAEMKLKASELIQKLFIHGMTYVVNDVLDSQTVVEYIGLEFGCTIEIDSSAKEKLCLLENAVRDEVNATDPEKLIIRSPIVAFMGHVDHGKTTIIDALRQSNMAASEAGAITQHTGAFKCTTPVGEITVLDTPGHEAFSAMRARGAEVCDIVVLVVAGDEGIKEQTIEAIEHAKGANITIVVAINKCDKPNFNVETVYRQLAELDLLPEAWGGSIATINTSAKTGEGLQDLLEMLALQAEVLELKADPSARARGLVIESELHKGLGAVATVLVQNGTLHLGEALVFNDCYGKVKTMHDEHNQLLQSATPSTPVLITGLSAIPKAGDPFIVVKNEKVAKEIISARLAGQQRSAALQKKRPNFDAVLQNKKTLKLIIKADVQGSIEALAHSILNIRSEKVDVEILSSEVGDISESDIRLASASKATVIGFHTSVESHAEPLIKNLNVKVCLFDIIYHAVDAIKEIMTGLLDPIAEEKNLGAAEIKATFKSSQLGTIYGCLVTEGTIVRNQKIRIIRDKEVLWKGSLSSLKRLKEDVKEVKKGMECGILLDNYQQAQVGDILQCYEVIYHPQKL
The following text describes a protein:
Function:
Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.
Subcellular Localization:
Nucleus.
Sequence:
MALLCGLGQVTLRIWVSLPSQSENGIGFLAARAFLRSGGMEALTTQLGPGREGSSSPNSKQELQPYSGSSALKPNQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPKLPENFAFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLSDKSATDELSHAWEDVKAMFNGGTRKRTFSLQGGGGGGANGGSGGQGKGGAGGGGGGGPGCGAEMAPGPPPHKSLRCGEDEAAGPPGPPPPHPQRGLGLATGASGPAGPGGPGGGAGVRSYPVIPVPSKGFGLLQKLPPPLFPHPYGFPTAFGLCPKKDDPVLGAGEPKGGPGTGSGGGGAGTGGGAGGPGASHLPPGAGAGPGGGAMFWGHQPSGAAKDAAAVAAAAAAATVYPTFPMFWPAAGSLPVPSYPAAQSQAKAVAAAVAAAAAAAAAAAGSGAPEPLDGAEPAKESGLGAEERCPSALSRGPLDEDGTDEALPPPLAPLPPPPPPPARKGSYVSAFRPVVKDTESIAKLYGSAREAYGAGPARGPGPGAGSGGYVSPDFLSEGSSSYNSASPDVDTADEPEVDVESNRFPDDEDAQEETEPSAPSAGGGPDGEQPTGPPSATSSGADGPANSPDGGSPRPRRRLGPPPAGRPAFGDLAAEDLVRRPERSPPSGGGGYELREPCGPLGGPAPAKVFAPERDEHVKSAAVALGPAASYVCTPEAHEPDKEDNHSPADDLETRKSYPDQRSISQPSPANTDRGEDGLTLDVTGTHLVEKDIENLAREELQKLLLEQMELRKKLEREFQSLKDNFQDQMKRELAYREEMVQQLQIVRDTLCNELDQERKARYAIQQKLKEAHDALHHFSCKMLTPRHCTGNCSFKPPLLP
The following text describes a protein:
Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTQFLFGLVFMEMALTVVLLFGSPLRTLLMLGLDRLKRGQGQLIAGTVATTMVVVFSATVYNLLGVQRRLTDATMISPTDQILLANSLLEASLMGFSLFLGILIDRLHYYASELYRLRNHLEETKSKQRDYLEMQGIGSSKTPHQSTKELTLKKT
The following text describes a protein:
Function:
Regulation of fluid secretion.
Subcellular Localization:
Secreted.
Sequence:
MMWWAIWCVMVVVSSAASAAPAPDSAPMDLVQIDSAGPDDESLGYAVSSLEGRYGAEAPWLYLLAEMPRDSQIGRAAVKRRMPSLSIDLPMSVLRQKLSLEKERKVHALRAAANRNFLNDIGKRGLQWSRSEQPSAYY
The following text describes a protein:
Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular Localization:
Nucleus.
Sequence:
MAAEQKATTEEVKMDLFEDDDEFEEFEINEDWVEKEEVKEVGQQWEDDWDDDDVNDDFSLQLRKELESDKK
The following text describes a protein:
Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Sequence:
MYRQLPNIGLRSCSARPTQLGSSRAIGTAIRSNRVMPIGISVCARYASRALHIHSPLNLGSSGVTSAEAAARSAPASSSSASASATAASNSYSDGGPATPGVTTDVKSRSVYITWASGITSKFHNIWLRDHCRCPQCYHSTTKQRLLNTFEIPPDAQPISAEATTEGLVVQWALLPSEHAATTSSSSLSDSADPNAAGSGAVGHHTSLYPWRWLMRNSYSPVLSDPITASSDDSGVKRIEKVLWGKGIGSAPPTVKFDEVMQSEQGVLKWVTKIAQYGFAFVTGVPPTPTDTEALIRRIAFIRETHYGGFWDFTSDLAHGDTAYTDLALQAHTDTTYFTDPAGLQMFHLLSHTASKSSGSSTTTTNSNSSSSGGGASAGSSASASSSTSSSSSTRGPSGGESLLVDGFLAAAVLKDVHPDAYETLSRVRIRTHSAGDENTMIRPLFEGGYPILQHDDATGELVLVRYNNDDRSVLRIDADDVERFYDALRKWNQILTNPEGEYWVQLKPGSALIFDNHRVLHGRSAFVGNRRLCGAYINHDDYRSSLAVLRSQFAENHAPRGVWDDGL
The following text describes a protein:
Function:
Possesses low quercetin 3-O-glucosyltransferase, 7-O-glucosyltransferase, 3'-O-glucosyltransferase and 4'-O-glucosyltransferase activities in vitro.
Sequence:
MGEEAIVLYPAPPIGHLVSMVELGKTILSKNPSLSIHIILVPPPYQPESTATYISSVSSSFPSITFHHLPAVTPYSSSSTSRHHHESLLLEILCFSNPSVHRTLFSLSRNFNVRAMIIDFFCTAVLDITADFTFPVYFFYTSGAACLAFSFYLPTIDETTPGKNLKDIPTVHIPGVPPMKGSDMPKAVLERDDEVYDVFIMFGKQLSKSSGIIINTFDALENRAIKAITEELCFRNIYPIGPLIVNGRIEDRNDNKAVSCLNWLDSQPEKSVVFLCFGSLGLFSKEQVIEIAVGLEKSGQRFLWVVRNPPELEKTELDLKSLLPEGFLSRTEDKGMVVKSWAPQVPVLNHKAVGGFVTHCGWNSILEAVCAGVPMVAWPLYAEQRFNRVMIVDEIKIAISMNESETGFVSSTEVEKRVQEIIGECPVRERTMAMKNAAELALTETGSSHTALTTLLQSWSPK
The following text describes a protein:
Function:
Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.
Subcellular Localization:
Cell membrane. Membrane; Multi-pass membrane protein.
Sequence:
MKLTIQWKLMASYLCLLLFIGGAFFVYLNHTLTTHLAHEIQENLKSESRLARMVAGREIRDMRRDAPAVAAAISRETRARVTVILEGGEVVADSDIAPQYLGTLENHANRPEVRQALEQGGGAAVRYSATIKTPMLYVATVLNTTTGERGVLRLSLPLTAVEKAKQSIRTLLGASLVVSLVVALLLSYLLSRLTSRSLRTITTLATQLGRGDYGRRIPVITRDEVGELARVMNEMASQIERNLARISAEKNRLDTILRGMGEGLMVSDAGGTVTLVNPAFLELFGLTQSVEGRQIIEIARFPELHETFRAVVSSRSEHVEEMTLPLGDEKQVLTHWVPLMEEDELRGVVAVFHDISDLKRLEVVRRDFVANVSHELRTPVTVIKGYAEALAGGLVEEDPERAGRFLEIICSHSERLADLIRDLLTLSQLESGGLQLELTQIHLDRAVSHAAGLLEQKAARKEIVIDISALAGAPPVLADPGRLEQVLINLMDNALKYTPPGGTITLSADEADGMVRVSVHDTGIGIPPKDLPRIFERFYRVDAARSRDEGGTGLGLSIVKHIIQLHGGSITVESEHGKGTTFRFTLRKT
The following text describes a protein:
Function:
Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm. Nucleus, Cajal body. Note=Nuclear during interphase, accumulates at the nuclear rim in prophase and localizes to chromatin throughout metaphase, anaphase and telophase.
Sequence:
MPPKKAAPKKLHELAPEVRVGLKIDDISKKTYIVGKQFATGGFGRIHTCTEDGKSQQMVMKIEPSTNGPLLTEVVVFNRILKKDMIENYKKAKKIQWIGLPHLIANGYFTYNNEKMRYMIIPKYATSLEAVREANGGSLSAKDSLTVADCVLGALEYLHDSDYAHADVKAANILLEKPNDFSSAVLVDFGLAHRTTNNVDKPDKKRAHNGTCIFTSTDAHRGNNPSFRGDVEILAYNLIMWISGSLPWLSLEASPDKVFEAKQKFVGGLPGTLQSILTNQPAPVAGCITTMFDVSRKTDYTHKVDMAKLRKKVTEAAQSASTGAQKKPKMTPSRDTTATPKRKSQRAPRVESEDEEEEEKKEVEIKPKKKVQRSRKVVEDDDEEEEVIIPKSTRSRKTKEEGTPRSFNLGMTSSTATSDRVAKKIEMKYKRLATNKPSLVPVTVADASSCESQYESNEPGPSSRVVKKRTSEERDANGEVQLKTPALVSPDVKKTKYKSGISSATKASPTELRRVPGVRNFPKGRRSMIIKETSARYQEKRATRNTKPTFDDSSCSSEV
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein. Membrane.
Sequence:
MNDSGVSKTYASALLGATNVPEEVEQELGDLAQLLFKDEKVKNFFLSPTVSNEEKEKVLIKNLRGKISDITLNFLGVLLNRGRIIHLPEIQKQFTVELDKKKGRVRAQVRSYPSLEPAQAAKLGSILSEKFKSEFILEVSEDKSLLGGFVVQFNDLKIEKSIASQLGEIKKSMLEKKLPVGAIYEN
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MAPSVPKKKRKVNLPENEEVAASIFEKHRSMAAQQPAGLPDHQARALSAAYTGVCSAKEPIRTPGDLARLKGVGGWVVDVMKDSFPGSSLDSSPPRSNTPGETGKKRKRNKPYVPQLNSAAYAIVITLYREMIRGTEIMKKQELIDAAEASGLSRKAIGPNNYKSKHGNSGSDFYTGWSCMKNLTEKDLVVKKSNPAKYYLTEKGKETARICLTKSGLDDPAGPFTATGHPESVMLSDSDSDEQEGSSPLIGSENFSERSGLPNSKAGNSSSFPTNNCRATNSPLSSQGMFGQQSFSAMGSAENSLLAMPPRQYDKSFLDTYEVVLILDDRDTFGARARRKVVDNIHTQFGVPVKIKHLPVGDALWIARHKQLGTEYVLDFIVERKNVDDLLGSIKDNRYKDQKLRLKKCGLRKLIYLVEGDPNTVDGSESVKTACFTTEVLEGFDVQRTNGYADTEKKYGHLTRSIIDYYRTNFSAGADTSRLCLTYDEFVKRSSDLEKVTVSDIFALQLMQVPQVTEEAALAVTSLYPTILSLARAYKMLDGDRRAQEEMLKNKSNMVNAGASKNIFKLIWVE
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Sequence:
QEVCVIGVFGKSAWGHVSKGMVLNKLTETSVFPTHYPDYSVNPSEMDRDPRLEKFMPKIEGYYDRKRKIVFLHLSTTLDAAALACACVEMGSKLTNHSDSHHFWKGQESEIVFSLVFLFSVCHILILVHPVSMFDISYDSLFHHISTFRGKLLPLVKDVLKECTVGRDWWVNGRPCPPRLLFVVQKSHLSNKRNPEAAGDATKKKKPPLKRLQHTLEDQIYKILRNSRVLTNNAINCLFTVPPNQAFVHIMTKQYSQVKRNEDPINSMLQLLRKSCETHRDPTAKSRAYRLLTNPPTQWEEEDEEEKENPLWEFLSQHTELVFDKKGFKDSVGRNPLPTHFELPVLKNWMKVANELFKLFFSTLKIEKDEEVQVKTSEIKQQLQVHLDPEMRFSEARCGKVVSHASAAYQANLPLHYTSKVHRNQLAQALATYALHARGPAKDKYEVCVQAECEAFWNDGRRLCEVRSLTGRHCVHRFHDLPDDLKPQPDANPPKMFHSSRSRSLAASSCGRIQGSREDPFTLKEANCGFYARLDARAHVLPDSDIYKFPIHCSEKQDKGLVSDELHKFVEQMTISGKEVDESASKPNKFVEQMTISGKEVDESASKPKTSTSGCEKSEAEEVEEATENTDSESRQRTVSANYELFTEGMIHSQLALEGVLPLFSSWSLVRLGSSNLYTPNRGLEFPGFLPGTNYLVPWEISIMTEEPGTTHWPVPGEARKLPIKETKLTLRETTTKAYVGYEYETPRGQRFICSGPDKSVKVTSSGVVRDPIQPLLDLNMPLFTLSPVSGRSGKMLTGQLMRVIVITPPESSVRINMKPQVVPGPSPAPTFYPSDPEISLRPNSMWVLRLPYVYVSESGPHIQPKDSSQLQAWRVLKMLSAEVDK
The following text describes a protein:
Function:
Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.
Sequence:
MTVKESRTRTRRTAAKAKLDLSVIGEGRRRVIIEAVEPIIDGGRYPVKRIIGDTLVVSCDLFADGHDELAAVVRHRPVSAKTWHEAPMRLLVNDRWEGQFTLNSIGRHEFQVVAWIDRFATWVHQLEKRLAAGQDVRVDLQIGAALVGEAARNASGADAAVLHVAEAALIAGDVDTAFAAEIHSLMAVHLPRRFATESEIYPITVERERARFSAWYELFPRSAADEPGRHGTFRDVIKRLPYIAELGFDVLYLPPIHPIGYTFRKGKNNSLNAGPNDPGSPWAIGNADGGHMSIHPELGTLDDFRALVREAQKYGIEVALDIAFQCSPDHPYVREHPEWFRARPDGTIQYAENPPKKYQDIYPFDFESEDWQGLWQELRRVFEFWIEQGVRIFRVDNPHTKSFRFWDWCLNSLKSAHPDLIFLSEAFTRPKVMYHLAKIGFTQSYTYYTWRTTKHELTSYLQELNTRPVSDFFIPNFWPNTPDILTPQFYAGQRSVFMTRAAMAATLTASWGMYGPVYELMEHTPVAGREEYINNEKYEIRHWNLDAPHSLRGYIGQLNRIRREHPALHRNDTLRFHRVDIDFHEHEWLLAYSKTSPDGSDIILVVVNLDPERTHSGWVQVPLNDWNVNGVFQAHDLLTDARYTWSGEYNYVQLSPMAPVHIFCIRRLRRDERGFEYFA
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MPPPDDSSAASSATAPSESYAKVLQGRYELGRVLGRGGSSKVYRARDVRTGVHVAVKAVRKPRHPCPPEDAAAARRSVERDLAALRRVRGHPHVARLLDVLASRSAVYIVLDLARGGSVQSALEERGRYDEPAARRLFGQLASALAHAHARGVFHRDVKPENLLLDERGDLKLTDFGLCAFADRQLGADGLTATACGSPAYVAPEILLKRRYDPGKADVWSCGVVLFSLTAGYLPFNDGNIMGMYRKICSGRFRCPKWFSLELRSLIGRMLDREPNTRIKIGEILDHPWLRKDGMSFVITATTSSSHPTPEVVKWEAESELAREMNAFDILTFASGCDLSGVVGAFTDRVRFLVSGRNAKSVLDKVEELGREEGFAVRRKEEAGFGGVLLEAIWGKFIAQVSVHPLHEQILLIEAERASNQEEPEFWEKLQASLKFSKN
The following text describes a protein:
Function:
Rho GTPase-activating protein involved in the signal transduction pathway.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNNNNRASIYGGLGSVGKIFGAPLLDVVMNQKSKTTSLNSSSSATNNNNSTVEEVNIPLFLHNGFKYIIQHGLGIEGIFRIAGTKDKVKQLQMQLDKGENIDYDASKVDPVDLADLMKIYFRELPDCLLQSDQYDHFISLLTLDRLGQIQKLRELVSSLRPENREMLKQLIWFLGRIAVNSTTNKMSEENLGLVWGPNLLWKGGKAVSTTDMMELMAGAGKIKLIVTLLIEEQEHVFNNLNATITKGEMKVSFINKIVGNKKTCQGISIIEDGESKSIWTADSAGIIKVFNADNYVTEREWDSNLGRIHTMTSVRDHAWIASSQSVSLWNKAGNLVKEFPGFHVSLTPVYSHGEYRIWAGTDQKITIFSSNTLEIVQTISIPGQFIVSITEIFGESNQVWVGATGGQIIIFDKTTGEEIRKLSTPAKRNITCLTFHKYMDKGKVWAGSEDKLIFVIDPFDDYSIVQTVSHPDLLLINTLKSISKSVWSCSRDSSIRIWDSNSFELLGSLDDYHTDAVIDAILTYNNRKMRWEFWTASFDKSVCIWSVSSELLSQPPPPLLNV
The following text describes a protein:
Function:
Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.
Miscellaneous:
MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Subcellular Localization:
Membrane; Single-pass type II membrane protein.
Sequence:
MGPPSSSGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKNRTLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIRVHANLQTIKNENLKNKKLSARIAAWLRRNT
The following text describes a protein:
Function:
Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system where the poison and antidote proteins are produced from the same locus; the poison component is trans-acting and targets all spores within an ascus whereas the antidote component is spore-specific, leading to poisoning of all progeny that do not inherit the allele; [Isoform 1]: Localizes isoform 2 to the vacuole thereby facilitating its degradation; [Isoform 2]: Forms toxic aggregates that disrupt spore maturation.
Subcellular Localization:
[Isoform 1]: Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole; [Isoform 2]: Ascus epiplasm. Cytoplasm. Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1.
Sequence:
MKNKDYPLRTSMDELSTKNDNEIDLEKGPLPEYNSEDGSTLPPYSDLNNPKQMGQNITKLFNWNKSTTPPDYDENRLPITDEGNNPPNTHRENHSSGTTDNSSPFLIKLLISFTSIILFNAPAVCYLKYKDAFFKNYGAAEWTLIGFWCASSLIIFTFSWYFYETWTKAVGKGIKHFLKKWRNIPMAFSEVFLFNILVGSPRVALRHISGERWGLKCSLADHIIFAILSILVFIVETVEPGSSKINIMKRLRGDNARDATQHVNEYTAVPLREMNPESEA
The following text describes a protein:
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MNEIVSLGLARIKKSALELIDDEIVGREEQKRGIESNIDVFIQSPCTRILFINGTPGTGKTMMVQYLLKKHQNEITTFFFNAIKEKSIINICRKVGGLKKSSSEEKVMERLLKRLDKIKNGIIVIDEYDVLMNDEGPLYRFFDWIFNKSPLMMLILISNNSQYSQILHSRVASRNVTFNYNFYQYTSEEIKNILLKRIGEEVIYEIFNKKDFDYFINERIEMSLQNGDVRKALGMMFNILLNTKERIEKGEDIKLSHQKVNELITSNSSYPTLNTCSQMELIILYCIMKCKEEEYGYESIMKYLDGIRYKKSDLINWNEFIVKSCISRLEKKELISVSSNEGKIKIKCNEIDKDMVLTMINSMNNITSPFT