lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription (By similarity). TFB6 facilitates dissociation of the SSL2 helicase from TFIIH after transcription initiation.
Miscellaneous:
MISCELLANEOUS: Present with 3510 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSEPNTPLHAQPNEQLDLNNLNDLDEKDIDDLNLDPNSDVEISADSGDVVNSNIDNVIWQRNCNKKRRYHTPEFNDVYNETNNTINDVTMLDDVDDFQPRINVSSPFSSATKLSELLPNDHNGTSHPRRLSMSQQSKFISYVDDQLLQIQRKFVQSRGLNIKNGYASLTPLLQDLKTLVDFVWYSIAHVPNSDYLLQSEEKRHCPDSRNPKDTCGYSSYFGQGSYLIKIADDLIDYVEKFTFKNMEDSEINDTLSKLFKLFFILDRIFVILTDDNDNCKEVPKTSSASKNIAGLNGTDIVRLKGIAERTRVRLPIFLESQGIHGYHYELSKIYEGFLDHANSF
The following text describes a protein:
Function:
Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection.
Domain:
The CRIB domain is involved in the interaction with CDC42.
Sequence:
MTSIYTSDLKNHRRAPPPPNGAAGSGSGSSSGSGSGSGSGSGSGSLTNIVTSSNSLGVTANQTKPIQLNINSSKRQSGWVHVKDDGIFTSFRWNKRFMVINDKTLNFYKQEPYSSDGNSNSNTPDLSFPLYLINNINLKPNSGYSKTSQSFEIVPKNNNKSILISVKTNNDYLDWLDAFTTKCPLVQIGENNSGVSSSHPHLQIQHLTNGSLNGNSSSSPTSGLSSSSVLTGGNSGVSGPINFTHKVHVGFDPASGNFTGLPDTWKSLLQHSKITNEDWKKDPVAVIKVLEFYSDINGGNSAAGTPIGSPMINSKTNNNNNDPNNYSSAKNNVQEANLQEWVKPPAKSTVSQFKPSRAAPKPPTPYHLTQLNGSSHQHTSSSGSLPSSGNNNNNNNSTNNNNTKNVSPLNNLMNKSELIPARRAPPPPTSGTSSDTYSNKNHQDRSGYEQQRQQRTDSSQQQQQQQKQHQYQQKSQQQQQQPLSSHQGGTSHIPKQVPPTLPSSGPPTQAASGKSMPSKIHPDLKIQQGTNNYIKSSGTDANQVDGDAKQFIKPFNLQSKKSQQQLASKQPSPPSSQQQQQKPMTSHGLMGTSHSVTKPLNPVNDPIKPLNLKSSKSKEALNETSGVSKTPSPTDKSNKPTAPASGPAVTKTAKQLKKERERLNDLQIIAKLKTVVNNQDPKPLFRIVEKAGQGASGNVYLAEMIKDNNRKIAIKQMDLDAQPRKELIINEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGGSLTEIIENNDFKLNEKQIATICFETLKGLQHLHKKHIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRNKRATMVGTPYWMAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEPPYLNEEPLKALYLIATNGTPKLKKPELLSNSIKKFLSICLCVDVRYRASTDELLEHSFIQHKSGKIEELAPLLEWKKQQQKHQQHKQETSDTGFA
The following text describes a protein:
Function:
Probable inactive secreted aspartyl protease. May promote an inflammatory immune response in the host when the host skin barrier is breached. Has no detectable protease activity in vitro on fluorogenic substrates, a peptide library, or with the general protease substrate casein. The presence of the enzyme also does not affect the activity of the secreted aspartyl protease SAP1.
Subcellular Localization:
Secreted.
Sequence:
MQLTIKALVGILTTISAATAVSFDMENLGAEKRGVSGEELHMLHGNEVLARFANGVYPEVANGTRVSKRAGGAEVDLTSVGGGTAWAVKAKIGSNEEEVTMLLDSGYEHALVAADSDYSPGKSSSNENTGEKFFAGFLTGGGNEGTIHLDDLSVGGLKASKFAFGYTKNRDFSSNQKLGGILGMSLPGHVDYVPGFKNHGWGGFIQTLKNQGVIDEAMYQMTLKGDGGKLSIGEVDDSQYEGDLETLMNTGKAYGHCGFKGTLNGEKHNFLLDSGTTGIAGSYDSVKKFLQGMSGVELVEEDKRGSVTGKVDCDSMPSFKISVDGKFDVKLSDDVMKKYDLGNGKCLLPIYGYTNMPKSYSYNWIVGGAFMREVSVVCKFDSNEMQIARQ
The following text describes a protein:
Function:
Catalyzes the isomerization of 2-oxo-tetronate to 3-oxo-tetronate.
Sequence:
MPKFAANLTMMFNEVPFLDRFEAAAKAGFKYVEFLWPYDYPAQELKAILDKHGLKVVLFNTPAGDVNKGEWGGSAIPGREADSHRDIDLALEYALALGCPNVHIMSAVVPEGASREEYKQTFIKNVRYASDKYKPYGIKIQLEALSPEVKPNYLLKSQFDTLEVVELVDRDNVFVQLDYFHAQNVDGNLARLTDKLNGKFAHVQIASVPDRHEPDEGEINYQYIFDKLDEIGYTGYVGCEYKPRGETVTGLDWFQKYK
The following text describes a protein:
Function:
Plays an essential role in viral DNA replication. Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond, generating the dsDNA replicative form II (RFII). In turn, viral DNA replication initiates in the presence of host Rep and DNA polymerase III at the 3'-OH of the cleavage site. After one round of rolling circle synthesis, protein A is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single-stranded molecule ready to be packed into a virion; The A* protein binds to double-stranded DNA and prevents hydrolysis by nucleases. Additionally, A* is an inhibitor of DNA replication and may have a role in the transition from semiconservative replicative form DNA replication to single-stranded DNA synthesis in the life cycle.
Sequence:
MVRSYYPSECHADYFDFERIEALKPAIEACGISTLSQSPMLGFHKQMDNRIKLLEEILSFRMQGVEFDNGDMYVDGHKAASDVRDEFVSVTEKLMDELAQCYNVLPQLDINNTIDHRPEGDEKWFLENEKTVTQFCRKLAAERPLKDIRDEYNYPKKKGIKDECSRLLEASTMKSRRGFAIQRLMNAMRQAHADGWFIVFDTLTLADDRLEAFYDNPNALRDYFRDIGRMVLAAEGRKANDSHADCYQYFCVPEYGTANGRLHFHAVHFMRTLPTGSVDPNFGRRVRNRRQLNSLQNTWPYGYSMPIAVRYTQDAFSRSGWLWPVDAKGEPLKATSYMAVGFYVAKYVNKKSDMDLAAKGLGAKEWNNSLKTKLSLLPKKLFRIRMSRNFGMKMLTMTNLSTECLIQLTKLGYDATPFNQILKQNAKREMRLRLGKVTVADVLAAQPVTTNLLKFMRASIKMIGVSNLQSFIASMTQKLTLSDISDESKNYLDKAGITTACLRIKSKWTAGGK
The following text describes a protein:
Function:
Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the distal portion of centrioles. Localizes to the inner scaffold in the central region of centrioles.
Sequence:
MSSDEEYRESPILPKDSDHGSSVSSDLQDEYDELLRYAVVTPRFGPHFPEQNQLFTEQIKSDRFSSPKDPVQEQSLARNYSEENIPECSATSTSQRRSPPTANEEERAMSEKKSFLSGLEAFSPLHSEDLSLGGSTSSGSQVQQVRVKELPVPAENMDKVEDVLDLWSGTLKTNVMAELSKWRLTVIEQHKLEIKNQNEKHAEQISQLSSQIDKLQDHLQTYETSIQRKDEVISNLTHALEKHKEKMELMRTFTHWRLQLTEAREEDYARSLADRHYRNTLMKNAWKAWHSVIQSNWKDKIEQACRARAEEVCIELSNDYESKLTQLNSALGEARAEVQRLLAERGQFEGSMKKAFMRGVCALNMEAMSMFQGRESRMEYDPPPRREERDPSPSVTFQNPPVTSTHTSSTQHELQSALHSPVTCEPNYIHAFGPSTVSQSKEEAGAPAVISAATSASSVLSTQKLPMPRVVTSCQQKAGKIITARISARPDVSQRSSKIGSNITSMAVSPPISSIVVEKHHPVTQQTISQAAAAKYPRSALQSANSVGGRSTGQSGRVSQSHAGIHSIKVVD
The following text describes a protein:
Function:
Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
Subcellular Localization:
Nucleus. Note=Associated with discrete nuclear foci.
Sequence:
MSPPGKVPRKENLGLQCEWGSCSFVCSAMEEFFDHVTQHLQQHMHGSKEEEEEDPLEEEFSCLWQECGFCSLDSSADLIRHVYFHCYHTKLKQWGLQALQSQADLSPCILDFQSRNVIPDTPDHFLCLWEHCESVFDNPEWFYRHVDAHSLCCEYQAVSKDNHVVQCGWKGCTCTFKDRCKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQTSLDQQRFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEDRPYKCDCCDYSCKNLIDLRKHLDTHSKESAYRCDFENCNFSARSLSSVKSHHRKVHEGDSEPRYKCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLLQQLQEGSDPGLALNESSLQGIVLETVLGGPGPEEETEEEGRVVEGTALSASQDNPSSAIHMVSQTDTQGQRDIVYCVLSEGPGEPPPVSETLKRDGKARGT
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTAPNSTPASSRKRVRRRRQDKPALSAKLVLDAHVKGDVGVIATDLFADLFPHLWANGDSQDTVHVAIAPWAPSQTPEANNWSIVPVIRSSTVAPSTVQFSPSSLALQSFATHLQQAAPSKLSGHNKGGIEILILDVSPIELDTVFVNLDGELAKRLEDGEGTFFREHPVNGKGKARADATPEEHLTAALRTALGTLKIVHSGDFFPLPLPPHPVTHQPPNPGRITLCEPVAQGILAPTTKIIVSRVRTSKTKRSSASGQQQGRKLNGVAEDDEDAYFSAAEEDRDSKTNAQTAETDADDTEFEPQAGEDEDNLSDDSLDEIISLQVPTLPTTVTGQSTIGTGTPTMLRGRKTNGPGSVISSYTATTARPDRPRGRLFKAHGLMKPIPPDLLHPKPTPEDDEEACIYVDMRDLTRVGCFSGDWIRVEAASEPPSNGLGAFGLGSFVEQEADEINWRPARVFGLPEGYSSRSATRSHHSRHDSRNSSFFEAQSQKSNPPAYTSPILLANLDNPPYLRLSPIKRPSSSIIKGVAAQSKTSSTLKPPFAREVILQHVRTPTAVERDVQSAVMAGLKHYFERRLRVLRTGDLIAVPIDTQLGKALQESTIPGEDSAIDEVLGLIAATRPGQSLHYDDVAWFRVGHVQAMKQDTTEAVDGEEAEDLWGGIACVDISLTHLEQSGSVTGRIPGTISNSWQYYLGIRKLPKHQQNPGLPAQLQTLEPEKQYVSSLRRKLRELMAAATSKPALHLNLPPLAILLVSTQRHIGKAATAMQACSDIGLHTFAIDAYDIVNDGGGGGGSDVKTAGFLTSRAERAMSCGPESCVLLVRHIEALTADRMVSSIKEILADARVLIATTTEVEKVPDGIRALFTHELEMSAPDEQEREGILSSILADRGIGLDHGVDLSGIALKTAALVAGDLVDVVDRALVAQRSRLEKLTAKATGSITFRDVQLAGGPAASGLTKQDFELAVDAARKNFADSIGAPKIPNVTWDDVGGLGNVKDAITETIQLPLERPELFAKGMKKRSGILFYGPPGTGKTLLAKAIATEYSLNFFSVKGPELLNMYIGESEANVRRVFQRARDARPCVVFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSGGEGGGGGVFVIGATNRPDLLDPALLRPGRFDKMLYLGVSDTHDKQVTIMEALTRKFTLHPTVSLRSVAERLPFTYTGADFYALCSDAMLKAVTRQATLVDTKIRELNAAAGPEGKQISTAYFFDHYATKEDISVMVTEQDFLDAHRELVPSVSAGELEHYEQVRAMFEGAKDKDKKKEGAGGDGNGVDGLESGNRNGMLAITMGDDGAGAESTKKDGKGKGKAADNEVNGAGEGKGKEGVSPFQESGGDEDEGLYD
The following text describes a protein:
Function:
Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose-dependent manner.
Subcellular Localization:
Secreted.
Sequence:
MQQAGLTLMAVAVCVAFQTSEAILPMASSCCTEVSHHVSGRLLERVSSCSIQRADGDCDLAAVILHVKRRRICISPHNRTLKQWMRASEVKKNGRENVCSGKKQPSRKDRKGHTTRKHRTRGTHRHEASR
The following text describes a protein:
Function:
Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MFRRGLVFSRHCHYSLIRPRFPLNRTCLARFADGRKNLATDNRTQTYQSWRGMISIRALLLAAATSVGLYAYFQHEKKKVLERQNDKVLATIGRPQLGGAFSLIDHHGNRVTDNDFKGKFSLIYFGFTRCPDICPDELDKMSAAIDIVNNVVGDVVYPIFITCDPARDPPQEMAEYLEDFNPKIVGLTGSYEEIKDICKKFRVYFSTPKNIDPKKDDYLVDHSVFFYLMDPEGKFIEVFGRNSTSEDLARAIGSYYLSRKKQK
The following text describes a protein:
Function:
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
Subcellular Localization:
Cell membrane; Single-pass type III membrane protein.
Sequence:
MDVTTSAWSETTRRISEPSTLQGTLGSLDKAEDHSSSIFSGFAALLAILLVVAVICVLWCCGKRKKRQVPYLRVTIMPLLTLPRPRQRAKNIYDLLPRRQEELGRHPSRSIRIVSTESLLSRNSDSPSSEHVPSRAGDALHMHRAHTHAMGYAVGIYDNAMRPQMCGNLAPSPHYVNVRASRGSPSTSSEDSRDYVNIPTAKEIAETLASASNPPRNLFILPGTKELAPSEEIDEGCGNASDCTSLGSPGTENSDPLSDGEGSSQTSNDYVNMAELDLGTPQGKQLQGMFQCRRDYENVPPGPSSNKQQEEEVTSSNTDHVEGRTDGPETHTPPAVQSGSFLALKDHVACQSSAHSETGPWEDAEETSSEDSHDYENVCAAEAGARG
The following text describes a protein:
Function:
Endogenous low-affinity ATPase inhibitor, which inhibits specifically the reverse ATPase reaction of mitochondrial F(1)F(0)-type ATP synthase. Found to stabilize, together with STF2, a complex of intrinsic ATPase inhibitor INH1 and proton-translocating ATPase in mitochondrial membranes. Binds directly to purified F1-ATPase.
Subcellular Localization:
Mitochondrion.
Sequence:
MLNRCISRNTRLPVNLRIASRFYSDGPLGGAGPGNPQDIFIKRERAKEDYYARQQEREQLAHVKEQLKEHKKKLENLENKINNLSK
The following text describes a protein:
Function:
Transcriptional repressor. Required for pronephric kidney development (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPAAVDHLQGLYGLSAVQTMHMNHWTLGYPNLHGITRSTITEMAAAQGLMDARFSFPALPFATHLFHPKQGTIAHVIPALHKDRPRFDFANLAIAATQEDPPKIGDLSKLSPGLGSPISEISKLSPDRKPSRGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQTSSPTVVSSAEKFSGEIAI
The following text describes a protein:
Function:
Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Does not stimulate K(+) uptake ability of TrkH on its own, but increases K(+) uptake by 20% in the presence of SapD; has no effect of TrkG.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MIETLLEVRNLSKTFRYRTGWFRRQTVEAVKPLSFTLREGQTLAIIGENGSGKSTLAKMLAGMIEPTSGELLIDDHPLHFGDYSFRSQRIRMIFQDPSTSLNPRQRISQILDFPLRLNTDLEPEQRRKQIIETMRMVGLLPDHVSYYPHMLAPGQKQRLGLARALILRPKVIIADEALASLDMSMRSQLINLMLELQEKQGISYIYVTQHIGMMKHISDQVLVMHQGEVVERGSTADVLASPLHELTKRLIAGHFGEALTADAWRKDR
The following text describes a protein:
Function:
May act as receptor for class I MHC antigens.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSPSHVVVNVSTARSRPLTTSSAPVSRAESLRPGSRSCTMSMSPTVVILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARRGPTVRTGENVTLSCSSRSSFDIYHLSREGEAHELRLPAVPSVNGTFQADFPLGPATHGETYRCFGSFHESPYEWSNSSDPLLVSVTGNPSSSWPSPTEPSFKTGKHSNSERDLDAAVMNQEPAGHRTVNREDSDEQDPQEVTCAQLDHCVFTQRKITGPSQRTKRPSTDTSVYIELPNAEPRALSPAHKHHSQALMGSSRETTALSQTQLASSNVPAAGI
The following text describes a protein:
Function:
Transcription activator involved in G2/M transcription through its association with FKH2.
Miscellaneous:
MISCELLANEOUS: Present with 779 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MDRDISYQQNYTSTGATATSSRQPSTDNNADTNFLKVMSEFKYNFNSPLPTTTQFPTPYSSNQYQQTQDHFANTDAHNSSSNESSLVENSILPHHQQIQQQQQQQQQQQQQQQALGSLVPPAVTRTDTSETLDDINVQPSSVLQFGNSLPSEFLVASPEQFKEFLLDSPSTNFNFFHKTPAKTPLRFVTDSNGAQQSTTENPGQQQNVFSNVDLNNLLKSNGKTPSSSCTGAFSRTPLSKIDMNLMFNQPLPTSPSKRFSSLSLTPYGRKILNDVGTPYAKALISSNSALVDFQKARKDITTNATSIGLENANNILQRTPLRSNNKKLFIKTPQDTINSTSTLTKDNENKQDIYGSSPTTIQLNSSITKSISKLDNSRIPLLASRSDNILDSNVDDQLFDLGLTRLPLSPTPNCNSLHSTTTGTSALQIPELPKMGSFRSDTGINPISSSNTVSFKSKSGNNNSKGRIKKNGKKPSKFQIIVANIDQFNQDTSSSSLSSSLNASSSAGNSNSNVTKKRASKLKRSQSLLSDSGSKSQARKSCNSKSNGNLFNSQ
The following text describes a protein:
Function:
Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV
The following text describes a protein:
Function:
Involved in the degradation of glucose via the Entner-Doudoroff pathway (By similarity). Catalyzes the reversible, stereospecific retro-aldol cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) to pyruvate and D-glyceraldehyde-3-phosphate (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MSYTTQQIIEKLRELKIVPVIALDNADDILPLADTLAKNGLSVAEITFRSEAAADAIRLLRANRPDFLIAAGTVLTAEQVVLAKSSGADFVVTPGLNPKIVKLCQDLNFPITPGVNNPMAIEIALEMGISAVKFFPAEASGGVKMIKALLGPYAQLQIMPTGGIGLHNIRDYLAIPNIVACGGSWFVEKKLIQSNNWDEIGRLVREVIDIIK
The following text describes a protein:
Function:
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYSLQSAAGKDAAKQISWVKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEALVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGSKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNITVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDTKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTANVLGAVNKPLSSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKREDPDLSELEKPRSRKKAPVTDPEEKLGMDDLTKLVQEQKPKGSQRGRKRGRTASDSDEQQWPEEKRHKEELLENEDEQNSPPKKGKRGRPPKPLGGGTSKEEPTMKTSKKGNKKKLVPPVVDDDEEEERQIGNTEHKSKSKQHRTSKRAQQRAESPETSAVESTQSTPQKGRGRPSKAPSPSQPPKKIRVGRSKQVATKENDSSEEMDVLQASSPVSDDTTQEGAEEEDISVGNVRRRSSKRERR
The following text describes a protein:
Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.
Subcellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Sequence:
MASSSLQICSLLLALAGFTILLLTTMSNRWKISDTTAVLVPSEWISEGLWMDCGTTDFGAIQCMKFLHMLSSESLSQWYILIFHCHGVYIVTVLFQSHVQACRTLMIISILLGFKAAVISLLGLKCTNVGLSDEDEKVKVAVTGGFLFILGGLCSMVAVSWYAAMITAPFFNPLYTGTKYKLGDALYLGWAGSVLCMLGGIFLTCPCKGKEKQEYSASKYRYSAGQASGQQQIYTEDAETVSSPKEYI
The following text describes a protein:
Function:
Regulatory part that prevents formation of the Nlrp1a inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), preventing activation of the Nlrp1a inflammasome. In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1a inflammasome.
Subcellular Localization:
Apical cell membrane. Basolateral cell membrane. Cell membrane; Lipid-anchor. Inflammasome.
Sequence:
MEKRGQHEMEGVPAGCHSHIKLLRINREHLVTNIRNTQCLVDNLLENGYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLWLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYMDTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLASKAKFFFHFRCRMFSCFKESDTLTLQDLLFKHFCYPEQDPEEVFSFLLRFPHTALFTFDGLDELHSDFDMSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTARTGVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFHTAFEGSSQLPDCAVTLTDVFLLVTEVHLNRTQPISLMQRNTRSPAETLRAGWRTLQALGEVAHRGTDRSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQSQQSYEFFHLTLQAFFTAFFLVADDKVSTQELLRFFREWTSPGEATSRSCYPSFFSFQCLGSGSRLGPDPFKNKDHFQFTNLFLCGLLAKARQKLLQQLVPKAILRKKRKALWAHLFASLRSYLKSLPRVQSDGFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVRELQPCFSRLTVIRLSVNQITDMGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLTHLKLGKNRITSEGGRCVAQAVKNSTSIVEVGMWGNQIGDEGAKAFAEALRDHPSLTTLSLAFNGISPEGGKSLAQALKQNTTLTIIWLTKNELNDEAAECFAEMLRVNQTLKHLWLIQNHITAEGTAQLARALQKNTTITEICLNGNLIKPEEAKVFENEKRIICF
The following text describes a protein:
Function:
Involved in the catabolism of quinolinic acid (QA).
Sequence:
MLKDYALKILKKSLEYDVGFGDITTNSIIPEGVKAKGVIKAKEKCIVCGIDFIVAFFEEYGIKCKKLFNDGEEAYGNILEFEGDARTILMLERTALNLLMHLSGIATMTNRIVKKAKSVNKNVRVACTRKTLPLLSPLQKYAVYIGGGDTHRFRLDDCVLIKDNHIAIVGVKEAIRRAKENVSFTKKIEVEVSNLKELREALEERADIIMLDNFKPEEIEEALKIIDEFERKTNFKPIIEVSGGIKEDNILEYAKYNVDVISMGALTHSVKSVDMSLDIVRYQ
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
Subcellular Localization:
Chromosome. Cytoplasm.
Sequence:
MFSERILRFVFLSSVALSTPSPWTSGGSRGATPPDGTFVSPRIRHPPLSVSSTPDLQSFLQNDDEQERKQRRRSRVVDLQLSGTESPCSSTSPARRRAETPTSMVPKLTNTQISEHYSTCIKLSTENKITTKNAFGLHLIDYMTEILKQKDSELTNFKVAAGTLDASTKIYAVRVDAVHADVYRVLGGLGRDAPAAEAAGSPGADGTPVESGTAKKVQKPKKKHSYKTIEQNLNNLNLSEADRKCEIDPMFQKMAASFDECSTAGVFLSTLHCHDYGSELLFDSDVRPLSASDPLEVPDSGSVEVADIRTALLHCANRSQICPSLAGFQFTKWDSETHNESVSALLDKFKKSDQVFDVNAEVDNSDHEDYADAPGEDDFDADAADQTIAGDHGAFGSQEPCVYRSPRKDVIALGDGDIGTMCLHLSLKPGEYSYFSPRIMSMWAGPDHWRFKPRHKPEQNARENKKKSTKKIFEINFEDDIGFDVYFRKTKTATTLSRGTLENQNRKATTLPANFHYEPDNIIQLNLKPGSRLRKMVMQSASSEHEEEDVGDYDYDNPNDTSNFCPALQAADSENDDPDGYAEPGGPLDRTAHPNGGQENGQENGVHTNGSGVDITTYGELNLVAEPQKVNKIEIHYAKTAKKMDMKRLKQSMWSLLTETQKSSADKENEGIEKEEKLAVAGEKVFSDITKDLIHNLPSMMAQNLSVPLAFACLLHLANEKNLKLEGVEDLSDVRVMQGD
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MRQPLILLGVALSFLALVESGVLRREEHEFEKWTNVLGNGDAPPPPKYKVIMLRYAKKVINEPENRKMSCFFCTFAVDGVQALIAQNSTDDEVAAFLVNLCDLFDVEQPHVCKNIIYAFKDEVVFVLERSVFTPDEICGAFIANCGHSDKPLTHMWNISIPGGKPPIRPWPKIPDNKPTFKVLHLSDIHIDHQYVVGTEAYCQLDSALGTYAMCCRDYSQDSMGRPTNMKDKPIYVPAGPWGMPYLCDLPYQTFESAMKHISKTFKDLDYIIITGDFEAHDSWDYTEDLTRENMNNMTNVFLEYFPNVPVYVSIGNHEGVPQDAMAPHTMPEYDKRGPQWLYKIMSDMWAHWIPQEALDTVQYRASYVVRPKPGLKLISLNTIYCSEFNFYLYVNEVDPDATLEWLIEELVDSEKKGELVHIISHIPPGDNYCLKGWSWNFFEIVKRFENTIAQMFYGHTHYDQFMVYYDMDDPNRRPFHFNWISPSLTTYDFLNPAYRIYEIDGGYEGATYVREAIVHSNTVKSAQTYFANVTEANLKNKEPEWVLEYDTKEHWQLPDFSPQSWADLSDKLWTNTTMFREYVKFFYRNHYNNECYTDYKCRYTFVCDIKKGRSYDESFCDHLKR
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MTITELQQQYAAHPNTAVMERLLKDASVQTIFCGGLCASSASLFSSVLVKQDVCPFVFVLGDLEEAGYFYHDLTQVLGTEKVFFFPSSFRRSIKYGQKDAANEILRTEVLSRLQKGEEGLCIVTYPDALAEKVVSRKELSDKTLKLNVGEKLDTTFITDVLHSYGFEYVDYVYEPGQYAVRGSIIDVFSFASEYPYRIDFFGDEVESIRTFEVESQLSRERKEGVAIVPDLAVTGDVTTSFLDFIPKETVLAMRDFLWLRERIQVVHDEALTPQAIAVQEAEENGGITLEGKLIDGSEFTVRALDFRRMEFGNKPTGTPDAKISFHTSVQPIFHKNFDLVAGSFKDYLEQGYSLYICSDSTKQTDRIRAIFEDRGDKIQFTPVVRTIHEGFVDHTLHLCIFTDHQLFDRFHKYNLKSDKARSGKVALSLKELNQFTPGDYVVHTDHGIGRFSGLVRIPNGDTTQEVLKLVFQNEDVVFVSIHSLHKVSKYKGKDGEAPRLNKLGTGAWEKLKDRTKAKIKDIARDLIKLYSQRRQEKGFSYSPDSFLQRELEASFIYEDTPDQSKATMEVKADMESDRPMDRLVCGDVGFGKTEVAIRAAFKAVADNKQVAVLVPTTVLAYQHFQTFRERLKGLPCRVEYLSRARTAAQSKAVLKGLKEGEVSILIGTHRILGKDVQFKDLGLLIIDEEQKFGVSVKEKLRQLKVNVDTLTMTATPIPRTLQFSLMGARDLSVISTPPPNRYPIQTEVHTFNEEVITDAINFEMSRNGQVFFVNNRIANLPELKVMIERHIPDCRVAIGHGQMEPTQLEQIIFDFVNYDYDVLLATTIIESGIDIPNANTIIINQAQNFGLSDLHQMRGRVGRSNKKAFCYLLAPPLSSLTAEGKRRLQAIENFSDLGSGIHIAMQDLDIRGAGNLLGAEQSGFIADLGYETYQKILAEAVHELRNDEFAELYADEIKGEGQISGEEFVDECQIESDLELLLPATYVTGSSERMLLYRELDGLTLDKDVDAFRFRLEDRFGPVPPETQELLRIVPLRRLAARLGVEKVFLKGGRMTLFFVSNADSPFYQSQAFGKMIDYMMKYTRRCDLREQNGRRSMLIKDVTNVETAVSVLQEIVALPVKELDDH
The following text describes a protein:
Function:
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Sequence:
MGLDIQTEIDKIVIEKVKPEVEYYDVMGGSHRWEVKVHDHGKVALVDTMPRLAPVGQTADFSICQAARVSYGAGTKKVTEDKGLIRYLYRHQHTSPFEMVEFKFHCVMPVFIARQWIRHRTANVNEYSARYSVLPDKFYHPSIEEVRKQSTSNRQGGEEALEPKTAQEFLDYLDKVEENYKTYNELLEKGLSRELGRIGLPVSIYTEWYWKIDLHNLFHFLRLRMDSHSQKEIRDYANTIFALIRPIVPVACEAFIDYAFESLKLTRLEIEAIRTGSPLNTTNKREIEEFEEKKKLLFPNTQA
The following text describes a protein:
Function:
May mediate or modulate cell adhesion between embryonic cells during development.
Subcellular Localization:
Membrane; Single-pass type II membrane protein. Note=Expressed in membranes during embryogenesis.
Sequence:
MGELEEKETPPTETTAAQQEALEEPKETDKMLDKKEDAKEKTPSPQTSKPASPNAGKKSSPVAEKKIDDAELAKSKSGNGEEIIDIPAENGTKPDSADDKKISKEEREVKPKKIPIGGLKLPGFFMKNKPKADGDGAEGELLEKEKEEDKDKEANGDAATGSGKDEQKSRPGLGERLRSFFARKPSAEKEKKQLVNGDADAKSEATAEATPAEDASDAPPKRGLLNAIKLPIANMIPKKKSNDDVELGLGKAGLASMETLDDSLKDQDTVDRAPVKTNGTEELKGELKDEKLAAEEKLAAEEEEQNRPVSLLTRLRGYKCSVDDALIVFGILLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGDEDCLYLDVVTPHVRYNNPLPVVVLIGAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLECADIQCLREASSERLWAATPDTWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYWISKDIVPRYARVD