lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).
Sequence:
MFLIRRHLHSLINTAELLKIICASGPPSFSASAKMPKTFKNAKRIEGLDSNLWVEFTKLCADPSVVNLGQGLPDIPLPLYVKEELSKVAAIDRLNQYTRSFGHPALVEVLSSLYGKIYERHIDPLKEIIVTVGGYGSLFNAIQGFIDKDDEVIIIEPFYDCYEPMVKMAGATPVFIPLHYKPIKGNESSSASWTLDIDELGSKFSSKTKAIIINTPHNPIGKVYSRKELQSIAELCIKHDVICISDEVYEWLVYTGNKHIKIATLPGMWERTITIGSAGKTFSVTGWKIGWSIGPETLIRHMQTVQQNTIYTCATPLQEALARAFGVTLKHMDGPDCYFRTLPRELEAKRDRLTGLLSSAGLKPTVPEGGYFVIADVSSLNADLSDMNEDENYDYKFVKWMTKNKKLSAIPVSAFCSSSNKEKFEKFVRFCFIKQDSTLDAAEKIIKAWAKGS
The following text describes a protein:
Function:
Receptor for basic fibroblast growth factor.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MGSLWEVHVAQCRRCATGSVVIVLIFCAFLGVSADVDFVRYFGYYSNKALGGFNDEIINGLTASECAAECLAGTTNVPFGFCRSFDYRSGNQRCVLSREDQNTVSQSLDPDIGNRYHQLNDPFSFFTKTPDAGLNGFNTHVLSSYNATQCALRCLLGTDTVSTVNCRSFEYDKVYNKCILSVEDGITEPSEVGAAGSYPRFDFYQRNGECDSSPCRNSGTCRNSFDSPESYTCTCLPGWGGDNCETDIDACSPNPCHAQATCTDNPPPALDATCTCNPGYTGDGLASGGTGCSDACWSNPCHAQATCTDNCTCNPGYTGDGLASGTGCSDIDACSPNPCHTQATCTDNLPPTADATCTCNPGYTGDGLASGTECTDTNACSPNPCHTQATCTDNPPPALDATCTCNPGYTGDGLVSGGTGCSETASSSVAAIIGGTVAAVALLLILGAGLIFYRRRQKSHNQAGNRDVALTDIGDPPETGSGNEAFVHEVDTKKGHKRLSQLATVHDVKDFLEANGLKELTKSFKEHDVDGRALRGMNDAILKDLIPKAGPRARLTALLTEMKTPANPDDPVVSTSNLNYWEIPRANLKLGRRLGRGQFGEVRLGKVQNRGVTTTVAVKTLKSSASDSDKKDLLGELEILVTVGRHDNIISLVGACTKDDPLTIVVEYASNGCLRDWLKSNSAEEYQNQPAPTSDLPMEQLIQFGIDVAAGMSHLAAMQCVHRDLAARNILLGENLVAKVSDFGLSRDIYESEEYVKTAKSKLPLRWMAYESLFYSVYTTQSDVWSFGVLLWEIMAMGHLPYEGMKGKQMMDMIKDGGRLEKPLHCPDEIFVVMQDCWRTLPEERPSFPQLKTNLGRIIQAHKTYASLLQE
The following text describes a protein:
Function:
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Subcellular Localization:
Cytoplasm.
Sequence:
MENNSYPYDELLVNKDVDSDYCCPLCTLLLSVNLQCREGHVFCVSCWNKQLENKKECVMCRCEVKSIACLSKNRFLEKEIRKLNIYCPNRFLKDKDCNDCLIEDENGCKSIITIDQIDSHLKSCLYNYVNCSNPGCGEEHRANTVGEHEKVCKYQIVSCLLCNDNNIQRKDLKYHYDCICSKTKTHCKCCSTLIERGQLPQHMAEECGNVLIPCRYKDGGCDKYIPRCELSKHLIEEDNHHKYILNIIEQHKSRMDQLASSINSMKLNFENQNRYSGKWIISNWSEKLQQFPAKKFLPLSFNLSPMKPFSIRLYPNGTNAMWGNITISLVKEFIIESKIKFSFEIENVDLSKSEEQVKVDTFKCLNDSWSLQFFGTYDSNNGFIRDNSITINFTIIVEKCYENCFITE
The following text describes a protein:
Function:
Together with Cdc42, involved in establishment of planar cell polarity in the developing compound eye by contributing to ommatidial rotation. Together with DAAM and Cdc42, has a role in neuronal development of mushroom bodies.
Domain:
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.
Sequence:
MGAVKSRTITSADVDADEQLQHPHSHAHHHSMRNGHQHNGSISSGTLQKQDLRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRLSRTLEEMDC
The following text describes a protein:
Function:
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions. Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2. Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes. Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane. Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (By similarity). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD. Palmitoylates NLRP3 to promote inflammasome assembly and activation. Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Domain:
The DHHC domain is required for palmitoyltransferase activity.
Sequence:
MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLCVSPAVPIYNAIVFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHMEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRSKSKGSLEVTESQSADAEPPPPPKPDLSRYTGLRTHLTLAANEDSSLLGKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLVKTPLGRPAAPRFGKPDGLRGRGLGSPEPGPTAPYLGRSMSYSSQKAPAGVSEAEEVALQPLLTPKDEVQLKTAYSKSNGQPKSIGSASPGPGQQPLSSPTRGGVKKVSGVGGTTYEISV
The following text describes a protein:
Function:
Required for rDNA copy number maintenance and non-random sister chromatid segregation (NRSS) following unequal sister chromatid exchange. Binds ribosomal DNA (rDNA) preferentially binding to intergenic spacers (IGS) regions on both X and Y chromosomes. Essential for NRSS, a mechanism which contributes to the recovery and maintenance of inherently unstable rDNA copy numbers so that the integrity of the germline genome is upheld over generations and germline immortality is sustained. May be involved in transcriptional regulation (Probable).
Miscellaneous:
MISCELLANEOUS: Named after the Hindu god Indra who lost immortality due to a curse from Durvasa, likely referring to mutants displaying a loss of germline immortality.
Subcellular Localization:
Nucleus. Nucleus, nucleolus. Note=Localizes to the nucleolus (the site of rDNA transcription) during interphase and rDNA loci during metaphase.
Sequence:
MRNILLCENMTKVQKEVRCDHCGTSQGSKSVFSGQKVFLGRKITDVLETITHRSIPSSLPIKICFVCTSTFMSSAALIEKVRETVDRVQEQPAKKTKVAEIEEPSTQESDKKAVKVPKKNTTLRQRSKSIAAFPPSFVNGANTNTEIEIISASPKKLDKTPKKQISRLFEDNLNDSVKLTPAKEVSSTKKAFLNLFGNGGNDAIEVLTESEEEEDSDKGPITINTNNFQCPECEFHAKFPKPYKEHLQKEHGLQRPRIYPCTLCIKTFGVLKTLKNHLRDTHSRTFESEAKTKAKESKEKEAKSGAKNKIDAKAKETNAVSQRKKPKEKKSKEKKTEIKCNVETKVVDEIDDQVNNKKGTDSEDADQTQATKIASFKALNESLMKKRMLENVIDSEYTFAINGSSASTPRADSNNFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMTLHADGAEAPNSSKRKILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKAAKFTNRKILQEEDEVVEIVDAFKTDNTAEDDEGPAEEKIIRSRNNIQHQVDGGMIAPRSPAKKTKKTSHVDLSVSTTNGNSPAKSEKRKKQDKSEDTLPSSDVDIVEEINYNVRPHKKARLESIGDSTADESTLSCDRCGKFVKSRQRLDSHMEKKHAAKLQCTLCKEVYQNQMDYVAHFSNCGSEGGLPCGVANCKKVFTEANFLSSHLRKRH
The following text describes a protein:
Function:
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKEKEVKRYIPWVIGIGSSFTILLLLLGSFWLYQLHKKIKSRKMKENFFKQNGGLLLQHQISSEESNVEKTKIFLAEELEKATDHYSINRILGQGGQGTVYKGMLVDGRIVAVKKSKKLDEEVDKDQVEQFINEVVILSQINHRNVVKLLGCCLETEVPLLVYEFISNGTLFHYTHNQSEDFIFTWENRLRIAIEVAGALSYLHSSAATPIYHRDIKSTNILLDDKYRAKVSDFGTSKSIAIDKTHLTTRVQGTFGYLDPEYFQTNQFTDKSDVYSFGVVLVELLTGEKPISSTRSGEGKNLANYFISSIKENRLFEILDVQVVKGGEKDDIEVVANLAKRCLNLNSKKRPTMREVSIELEGLRMSAGHTMIQQNLQQVESFIAVPSSIWDGASTSNGFRSLESSVTVPLDDQPLLFNTSSYSYYSKLMIEYGLATTAEKFLLLICFTPWYLPHHFCKPGRIARNGGAQRPTLQFISLSLLLVLLKDEVAAASSSLALPGCQDKCGNVSIPYPFGIGSNCSKNSSFEVSCDSTAAAGYTPTISIGLPPASEVVEILPENKVKIITDRLWLFNASENESNYFLNLIGTPFYLSQDRNVFTTVGCDILGYMISGGIRVGGCLSXCIXMSGTVEVNKRVRIAPTGCNGGYGCCQTSILPLLQYLELQSSRETALNDTAYAFIADKEWLGNDFNVTAYRENPTAERPVVLDWVIGNGTCETANPSSNCGPNSYCRNVTSGDGYACFCNRGYEGNPYLXQGCHDIDECADTKTNDCGWTCVNGPGNYSCSCPXGYHGDGKKIGVGCMKENEVERYIPWVIGISSGIIFLIGGFWLHWGFHKRRLYKLKEKFFQQNGGLLLKQHLSSRNGPTEVIKIFTVDELRKATDNYNVDRILGQGGNGTVYKGILPDDREVAVKKSKIIDQSQVEQFINEMVILSQINHRNVVKLLGCCLETEVPLLVYEFISNGTLFHHIHNEGHKFTLSWEDRSRIAAEIASALAYLHSTASPPIIHRDVKSVNVLLDNNYTTKVSDFGASKLIPSDQTQITTLVQGTLGYLDPEYFHTNQLSEKSDVYSFGVVLAELLTGRQALSFDRPEEERNLARHFVSLVKENNIHKILEEQVMHESSEDQLQEVTELAKRCLNVNQEERPTMKEVEIELERFRRVVLPMIEHDSQEAECLLGEPSDLHHSNVIYDSSMNDHLAVSLDSALEMIAQNRC
The following text describes a protein:
Function:
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSEVEMNFTNNVFGSEFALNSNVQISAADFHNFTTRFNKTRGSGASSGVFESELIIPLYAIIFVLSIVGNSLVLVTLVRNKRMRTVTNVYLLNLAISDLLLGVFCMPFTLVGQVLRNFIFGATMCRLIPYFQAVSVSVGVWTLVAISLERYFAICRPLKSRRWQTQFHAYKMIAVVWLASLFWSAPVLAVSSLKAMKGRGHKCREEWPSKSSEQIFNLFLDAMLLLIPVLIMSLAYSLIMTKLWKGLRREIQHNNSFQAQMIQRSNSSPTINGELNKSTSPQSTSEPSGMNHLRPTNRLLPPSHNKAHSRVKDAKHSKKTESVKMWFMKGIVQVRLPASIKKGYTCNTQTKSTLVPRCELTTPSSEHCSYNELCPSNDASYATSSVDETTYHFTRHAIRSNYMDKSIEAKKKVIRMLFVVVAEFFICWAPLHILNTWYLFYPEDVYLYVGSTGISLVQLLAYISSCCNPITYCFMNRKFRQAFLAIFNWYNVCYCCVCMEPKSHRTRTKTAQKNGIHKIIQNNSDVSCNESTIYIGRQSTIGRSEVVVLEAEDRV
The following text describes a protein:
Function:
Transcription factor that may regulate root development.
Subcellular Localization:
Nucleus.
Sequence:
MGSEYKHILKSLCLSHGWSYAVFWRYDPINSMILRFEEAYNDEQSVALVDDMVLQAPILGQGIVGEVASSGNHQWLFSDTLFQWEHEFQNQFLCGFKILIRQFTYTQTIAIIPLGSSGVVQLGSTQKILESTEILEQTTRALQETCLKPHDSGDLDTLFESLGDCEIFPAESFQGFSFDDIFAEDNPPSLLSPEMISSEAASSNQDLTNGDDYGFDILQSYSLDDLYQLLADPPEQNCSSMVIQGVDKDLFDILGMNSQTPTMALPPKGLFSELISSSLSNNTCSSSLTNVQEYSGVNQSKRRKLDTSSAHSSSLFPQEETVTSRSLWIDDDERSSIGGNWKKPHEEGVKKKRAKAGESRRPRPKDRQMIQDRIKELRGMIPNGAKCSIDTLLDLTIKHMVFMQSLAKYAERLKQPYESKLVKEKERTWALEVGEEGVVCPIMVEELNREGEMQIEMVCEEREEFLEIGQVVRGLGLKILKGVMETRKGQIWAHFIVQAKPQVTRIQVLYSLVQLFQHHTKHDDLLS
The following text describes a protein:
Function:
Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions. Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Sequence:
MSSESKEQHNVSPRDSAEGNDSYPSGIHLELQRESSTDFKQFETNDQCRPYHRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKIKEKVVTLGGIQDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQCNPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKNQKGVCVPNGLSLSSD
The following text describes a protein:
Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MPFDFRRFDIYRKVPKDLTQPTYTGAIISICCCLFILFLFLSELTGFITTEVVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGVGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHIIHKLSFGDTLQVQNVHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQRYSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTKVHLGTKGADIGNNGFYCYPVHHPTSVSL
The following text describes a protein:
Function:
Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. The affinity of HNF-6-alpha and HNF-6-beta for DNA differs depending on the target sequence.
Subcellular Localization:
Nucleus.
Sequence:
MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVGHRGSHLPPAHPRSMGMASLLDGGSGGSDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPLSGSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNDFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA
The following text describes a protein:
Function:
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSEAPRFFVGPEDAEINAGNYRRFFHHADEEEEEEEESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEDVILNEPVGDWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYHIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECSLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQNNDSDIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEGISILIPIAVMCM
The following text describes a protein:
Function:
Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.
Subcellular Localization:
Nucleus.
Sequence:
MASKRRLQMTPSRSDQDPDYEVISTPTAAKRQRVQEEDAKDQTVRRMQVVIKKQFNLALLDKEKEIEVVDERLQKARIQLDKLRACIVARYFGKAGLSSTSGEKSKQKLDLSHPAIQRALGQPSQSPSPPPTLQLGEGDISLSRPSSRGDGAPPFPPPMESGRSTPIGELLSRSEAFLDSGRSSPLLGPKGPRNSGEDTFGVGPPLDNLKPPVNQADAGEGSRLHVKKRIIVGNVSKYIPPXHREDSDPSTHKWMVYVRGPPEEPRIHHFVEKVWFFLHPSYRPNDLLEVKEPPFHLTRRGWGEFPIRVQLHFRDPRNKKVDIIHQLKLDRTYTGLQTLGAETIVDVELDRYLFNESGDPLSRPSTPTVTKVNYKEGLKPDLSRVPTPLRNSLALANDDARRQSLTSPSPLLLETLGKTPESTPDRSRPPSRSSSLSSPLVKSLPGDGSNRATPISIDSNYDRPREENSDITSTSALSLGKLSSRVKAQSGPALLHTAKPIRAMPPLGPISTNVNKSLVLEAIKTTQVSPTGTDSVVFTPSSLISGKGANNQVGKDAQVSPTHTGAINVGDVAISSPGSKLIRIQDGQIVQEVQPSRTVSPPQGKMENRTVVTLNQTVLGAKTNGKVTTQAAKQAVSGTPTVSLQRIPVPSFAGRSQTLVSSSNPSMQSTVSISQLAKQPVGASQLVRKGSTGVTLVQQSPSVRGPQQPQQQQPGVVPVMSNPPAGTQYYITAKSTDKNLQGKVILIPQQVFAGQSGKGGRGSNPGQASKQGSGSFLSPSNVLILPQGSIVPPLPPGSIVQIQPVPNPSSRPSSAPQTNTAGQPMTRIAVTQKSGASTIISPKPATQRVASGGGVIQIQRSAGQTLAKLVPAALGGASTSQQALTSSSISLIPEMKGQLARTPAGGVVLVQRTPSAPKSTNVQTISGIQNVVSGQVAPVSQKVALNPIPMTALSQQKASLPIKGGASVLLSQASKAVSSKTVVLQSQSASLLTNSNKTIQVRTGQPTVKTITKFVPPLDDVKDHFSKVTDKNNASSTASVVEVAENVLVKDEATGGASILNTNTSSDGNRLSNISLDSVRVKRADLIDAAKVIGKDRTAGATSSKSVLSPEGEVQNLESMQVSVSEICSDVEVAEVSNDALVQSDGNGVTPSTIVIKEEPNIDVEIEEAMEVEVGSDQATGNMNGHCDKTKSSFAKQQNPRVITRTNIVSEEVKKTNRAVVCDIAQRNKLSTTAPKTSVSGKCMIKVVNTRMQKPSCLAFDTSKVGGSKVHVIRIKQEPGTDPVLAALATAPILTLGKGAVVVRKEEEEEDGDDVEGWESKDLRIWKRLLGEHFEEQTNLYGVTSIEQLVKYVAEQAPLIDPTRVQNELPFCATSLEHYHSWTLAKRRSMEWQRVVFMRDKLTRLKARVQCLRKVPMWSKKRIVIWCRRHGFTPPEPGLKSSTQRSRCRFCGEVNCQRSEKTDERSAGTTGCLRNHLSKTGVLKNTTFSVPEELGERLKSCQSLRRGMSEDDDMEIDIISLGDPSKRLKVKTEGAEEKQQLKCFMPPSEGALCVREAAEKIGVHFRPIQVGEDTYSPVIQEMIYTATRQFLSDLVRASLSKSFGEREDHRLPEEILPLHVHQAVSSMPSCDFLTNSHLGVIASSSDSKKES
The following text describes a protein:
Function:
Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Sequence:
MDPNDKRSDSSQAEDVTESSNEKKCCTDCHTTRTPLWRGGPAGPKSLCNACGIKYNKKRRQQIDKTGTKTSKVLNRNGDLKMKMKMKLMVINQNQSQSQSQTQTHHNHDLQRSKRKRSSYERGKPWWNKLREEEQAAILLMAISCGGCLY
The following text describes a protein:
Function:
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSSDPVLVKKKLLQIASTGKYATFTPEQLHAHYEELQDFLILNQDSLLDSIELFNLYELQFYLSILTLHDIEAKNVLDKICDQFDFKDSNKNKGRSQRIKILQSVYVESKGEIETASKLLSEDPDELRLSRRLTTLSRHDKNPTKYINNLIYYLNLQPSDLIAWAELSEQYQKLGNYDKSIYCLKEVVLQNPLAYPIFYKIGLLYYYLFLQNEGNLKTDKKDKLFELMKILINSRDNYLYSLEINDKYEKNWVGLKTIVSLPFNDKLKKISESSKEIKDYLNYNEKLKPIIDRKLKELNISI
The following text describes a protein:
Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.
Subcellular Localization:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
Sequence:
MEIVNGQSSAITNFEAMRLLQQIKNRENKRPKHQKQKLHNLNNIVFEGLKYLKSTPAAHQTEESIKECIEALRPFGLTTSETMQLINTRPTTQVDIEVMIEESEERLPSEEQVDALITAVTSTLPERFIPKGKKKNVKKDMEEPLKTLNIKEEEYLYFGD
The following text describes a protein:
Function:
Toxic component of a type I toxin-antitoxin (TA) system. Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon.
Miscellaneous:
MISCELLANEOUS: Overexpression of this protein is toxic for the cell, affecting colony-forming ability and protein synthesis.
Subcellular Localization:
Cytoplasm. Note=Purifies with ribosomes.
Sequence:
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESELMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA
The following text describes a protein:
Function:
Probable transcription activator. Binds telomeric DNA containing repeats of the sequence, 5'-TTAGGC-3'. Binds to end-1 promoter, activating end-1 expression, which is required for endoderm specification during embryonic development.
Subcellular Localization:
Nucleus. Chromosome. Note=localizes to nuclei of interphase cells throughout early embryogenesis. Localizes to the nucleus in a lit-1 dependent manner. Transiently asymmetrically localizes during telophase of the dividing EMS cell with higher levels in the future E cell nucleus and low or undetectable levels in that of the MS cell.
Sequence:
MSDGSVERGTKRAEDSLATHQLTVQYKRYYIDVNENTRGRYIKIAELGTNYKSRIILSIVAAKAIVSEISKMLALIDEPSTGEHAPKESSLIKSETLNVDGRKFYVDLKENVRGRFLRIAQMPMNPRQTRQQIAIPSDGIAEIHKVLTEYLAKFGEGHEQENTNTPKITAENKSFLFHSGKNDRGEFVRISEIKLNSGYRNAITVPMSALVDFRKELDNIIANQGK