lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for classical and arginine/glycine-rich nuclear localization signals (cNLS and rg-NLS) in cargo substrates. Its predominant cargo substrate seems to be ribosomal proteins and ribosome biogenesis trans- and cis-acting factors. Required for nuclear transport of YAP1, NOP1 and SOF1. Mediates the nuclear import of histones H3 and H4. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus; Plays a role in protein secretion.
Miscellaneous:
MISCELLANEOUS: Present with 15500 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSALPEEVNRTLLQIVQAFASPDNQIRSVAEKALSEEWITENNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPPSSKLMIMSKNITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKLFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVNNKDNSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDIDEDDALRSYLEQSWSRICRILGDDFVPLLPIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATGTQNEELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRHGDGDEYNENIDEEEDFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDNEPILVIFALVVIGDLIQYGGEQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIPNVDTYTANWFKTLPTITDKEAASFNYQFLSQLIENNSPIVCAQSNISAVVDSVIQALNERSLTEREGQTVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWFA
The following text describes a protein:
Function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Sequence:
MSQHKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCEITSKAHVDYQVLVRNVVKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHMDKSSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNYKLHELRRSGELGWVRPDSKTQVTIEYASEGGACVPLRVHTVVISTQHSPDIALEDLRKELIEKVIKAVIPANLIDDDIIYHINPCGSFIVGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSIMVFSFGTSALSEEELLTIVNENFDLRPGMIIKNLNLKRPIYEPTAENGHFGHNAFPWEQPHHLKISSELLAKSQGPILPDTMGIAH
The following text describes a protein:
Function:
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.
Sequence:
MVLINRVNIQPEELPLLYHVNSMDVYNLLQDIGSSKIIIDLRTKEQYEKNHIRTSVNIPPPPSTTPLYENGEIKEFNLSKYIGSNVTAKHWNLIFQKLIVYSDKPFLYNIDELEKTISTTTITTTATTTTTTTTTSNSIGSDQDIIKSLKVSDWDKVVLRHFLLKKKKTKVIIYQGGFDQFQKDYSFMCNPSSSPSSSSGGGGGSQLYPSEIIKDFLYLGGAENAGNRQQLINLKITHLVNMAGELDDVYPHLYKYYRANLDDRPKANIYEHFEPVIQFINDCKKQGGRVLIHCAMGISRSTTVVLAYLMKEDHMTYSDAFTFCKQKRSCINPNFGFVKQLKDYQQHLTLEWEKQEKLKKQQQQTLNINNNNTGIPLSKKLQLDVSDPLSNSSPSSPLISSTLPIPETPPAIILKNEVASPCPIKTTTSSTTINNKGQQQDKAQEEKDSIFSYADKQEKMTHPTLHSPIELPQSSL
The following text describes a protein:
Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.
Sequence:
HGLKMTEESDHNNSTFTVDYVKNLVKKKDEIEEQIKAYYDVLEDQKGVGMDGPLVDVEGYPRADVDVFQVRTARHNISCLQNDHKAIMLEIEEALHQLHAREKAKRAWDEAEAREEAMEQARSPPQPFARVDAITPGSPASLAGLHVGDEIVEFGSVNSVNFQNLQNIAMVVQHSEGKPLSITVIRSGQTVHLGLTPQRWSGRGLLGCNIVPLRK
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MKLAASLNRLSPKRLFRTKSKASVSRSEPSSFSSNASSSSSDGSYGNLKQGPTATPISVLPQNSGDFYTELVQAFKLIDRDDDGVVSRGDLAALISRLSHEPPSQEEVSLMLREVDGGDGGCISLEDLASRVAGTSGEGSVETEELREVFEIFDVDRNGKISAEELHRVFGVIGDERCTLEECMRMIATVDGNGDGFVCFDDFCRMMVPAMNDHHH
The following text describes a protein:
Function:
Regulates ATP-dependent protein translocation into the mitochondrial matrix (By similarity). Involved in the uptake of thaxtomin, a phytotoxin produced by Streptomyces bacteria, that causes dramatic cell swelling, reduced seedling growth, and inhibition of cellulose synthesis. Modulates polar auxin transport. Involved in importing a negative regulator of plant immunity into mitochondria, thus protecting plants from over-accumulation of reactive oxygen species (ROS) and preventing autoimmunity. Confers sensitivity to virulent pathogens such as the oomycete H.arabidopsidis Noco2 and the bacteria P.syringae pv. maculicola ES4326.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein. Cytoplasm.
Sequence:
MAGRLLANLIVMGSGIIGRAVFQAYRQALANASKSGVAQEAMQNGVRQAGKAITEQEARQILGVTEKTSWEEILQKYDKLFENNAKAGSFYLQSKVHRAKECLEVVYRSQGNGTPS
The following text describes a protein:
Function:
Required for assembly of cytochrome c oxidase (complex IV).
Subcellular Localization:
Mitochondrion membrane; Single-pass membrane protein.
Sequence:
MPAGIFNSTYYGKDYRAGAALLRARRPYLFKNAATGLGLCMFTIGVYAYTIRAVGQDEFSDVKVPDAPAAAPQQSKQ
The following text describes a protein:
Function:
Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities, and in the production of gibberellins phytohormones. Catalyzes the conversion of (2E,6E,10E)-geranylgeranyl diphosphate (GGPP) to ent-copalyl diphosphate (ent-CPP).
Subcellular Localization:
Plastid, chloroplast.
Domain:
The Asp-Xaa-Asp-Asp (DXDD) motif is important for the catalytic activity, presumably through binding to Mg(2+).
Sequence:
FRSTAAGRCLPVTCCVFPRHFRVSSSSILPSNAKVVGGCKKNRQIAVEAAQSLEVDSQQPMNQEEVSEKMRQLREKIRWMLQNMDDGEISVSPYDTAWVAMVEDIGGGGGPQFPTSLEWISNNQLDDGSWGDLRFLIYDRILNTLACVAVLTQWKMHLHKCQKGLRFIRENIDNLENGNDEMMPVGFEVAFPSLIQTAKKVGIKIPTDSPFMKNIYAKRDLKLRKIPMDILHTKPTTLLHSLEGMEGLDWEKLLNLRTDDGSFLMSPSSTAYVFRHTKDELCHQYLLKSVNKFNGGVPNVYPVDMFEHLWCVDRLQRLGISRYFQVEIQECLDYVYKYWTNKGICWARNTNVQDVDDTAMGFRLLRLHGYDVSTDAFKQFEKAGEFCSFPGQSTDALTGMYNLYRASQTMFNGEHILADAKEYSTNFLHKKRLANAIVDKWIITKDLPGEVGYALDVPFYASLPRLEARFFLEQYGGDDDVWIGKTLYRMLYVNCDTHLELAKLDYEKCQAVHQLEWESIQKWYRDWNLVEFGLSERSLLLAYYIAASTVFEPERSRERLAWAITAILVKTIASQRQLPLETKGESLGSILENEDGGRLIEFLINTIHQLSSEIVVAEGRDITQQLSNTWQKWLKTCKEGGDDDLGEAEARLIVHTLHLSSGLDESSFSHPKYHQLLEATSKVCGQLRLFQSRKQVDVDLATGTTFQIEAGMQELVKLVFTNSSEDLDSLTKQSFFSIARSFYYTAYCDEGAINSHIDKVLFEKID
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSNNAQLLPSEWEYPEQNPDYKGNDLDKRLEQGPIEDRGCTDCIWCFLYLIMWGGLITIGIIALSNGSPDSLFLPYNSDGQQCGVSKNFEDCPYSYLMNTTSIEENQDGNFQFICVQSCPSKANTEISYCTVSGDETQLSSYGTYDCKNKYRTLKLDMSICSPYKSDPFWNVTKDFFSYSASEADFQDIGKTWSISLFVCIITLILANFIMFLVKKCASCLVWGVLILYFTLLILFGFLFYYSGKGDFSNAHFGNSYGWCLTIAIIFWSIAGMSLLMLGCYYKRIYLAIAVIKAAADFTRDVWQVVMVPLSIFGVMIGFLLFWIYSTTYLMSYGTSDYLDNTPFPEVDLHSGVIGMIIGNSIAFYWNCQFAMAFSQYVVASCCCMWYFHHMGVNLHRPVFKSIKRGLMHHSGSLALGSLILTFVAVLRFTFDLLHKMFKQGVQQNKAATGCLKCWFGYYGCIIHCFERFIRFITQNAYIMVAITGKSFCKSAHDAYYLIFRHKTAVAITDGIGEIFSTVANLSIGITATFIGFIMITQIDHYSNQISSPVLPTVFFAFISLTLSSIFMNVYGMGIDTILLCYMADRELFSTAKSVPQSLQEFLDKYQK
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGVQDGILGTGDARAGEGVSGKRRWLKRRERWLVVLGVALHAVYMLSIFDIYFKTPIVHGMDPVAPRFSAPAKRLVLLVADGLRADKFYEPDSEGHFRAPFLRSIIKERGRWGVSHARPPTESRPGHVAIIAGFYEDPSAVTKGWKANPVEFDSVFNRSKHTYAFGSPDIVPIFCGALPHSTWNSYPHEFEDFATDASFLDEWSFDQFQNLLDRSFTDEDLREALQQDNLVVFLHLLGCDSNGHAHRPFSSIYLNNVKVVDHIAKRVFDLVEGYYKDNRTAYVFTADHGMSDKGSHGDGHPSNTDTPLVVWGAGVKYPKSASASDHSDHGRFVDEHMHDTPTPTVWGLSGIERVDVNQADIAPLMSTLIGLPCPMNSVGNLPLGYIDMNEAEEVEAVLSNTKQILNQFLHKSHIKQSNTLFFKPFKPLEHYMSVVDQIEELISIGDYKAALKRSEDLRSLALEGLHYFQTYDWLMLMAVITSGYIGWMLYLVLHVLQSYTSLPGVLFRKERAVQQKKDTRKILVCGSAAMGLVSMILFWEQSPPLYHAYIAMTIFLWTRIIGEHQFLKALWRYLRGEKLNYVLKLLATLAVSVMIAEFLVNSFTERKLYTWCFLFAGVTAFCYLFYLIPWRSQIPAFVCLACWFLSGFTLMPAEIPDNNPLVISSGVMITVIGVAARWLDKHAEGSKYWSSICSRDMKKSKFSVLFLLQVLLVGLSSMMVSLSTSHRMQNQELHILHQFLNWLIAGSSMILPLFSENTLLSRLTSIFLGFAPPFLLLSIGYEAVFYGALSLALVAWLLFENTLLYLSKTEKNTVSNMSMVENAVLETDDRYLRLSDVRIPLIFMVLFNVAFFGTGNFASIASFEISSVYRFITVFSPFLMAALLIFKLFIPFLLVICTFSAIAKLIRVPRSGCYFLVILFSDVMTIHFFFLVRNTGSWMEIGNSISHFGIVSAQVVFVLLLFALTDIYTKDIRTRSDRPSSRKVR
The following text describes a protein:
Function:
May be involved primarily in the early steps of meiotic recombination.
Sequence:
MNIFPIVKYSVAEDSYTTDSSHINWSHYSDGGFTLSLTSGLLQIRQHEELIQSINLLDLWHQLIPGTKEKCLTLLSRAPCMNIRAFTNNVMKRFQVKFPSDVHYMKAKVEFEKLGLVFKDAKSSSEKKQFNNSQSQSNNSQELSLMNNAYNKSSAQQPNLLLQPSYIPMTQTATTAVNNSTNYVNPAPLQHVMPNAEIFSNTPPLKRFRGDAGMTQMPLRSDTSIESITASQQPTWDENVVITSSPFNPNRNAYSYGANSQYPIIAATPLNSQTQASWVAQPENQAYANLIPSPPTTSQILPTELTEEEKQLRSKVLFYLKQDSFIQLCQSLERVWNKM
The following text describes a protein:
Function:
lays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Also binds telomerase RNA and is required for its accumulation.
Miscellaneous:
MISCELLANEOUS: Present with 2400 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
C-terminal extension may function as a nuclear localization signal (NLS).
Sequence:
MKLVNFLKKLRNEQVTIELKNGTTVWGTLQSVSPQMNAILTDVKLTLPQPRLNKLNSNGIAMASLYLTGGQQPTASDNIASLQYINIRGNTIRQIILPDSLNLDSLLVDQKQLNSLRRSGQIANDPSKKRRRDFGAPANKRPRRGL
The following text describes a protein:
Function:
Required for nuclear positioning and completion of asexual development.
Subcellular Localization:
Membrane; Peripheral membrane protein.
Sequence:
MEDSQRGNASMMSMMDDPFVVSPEGARDPPSTNQYSTFDAQLFNLDASTPAQAKRALEAHLAETERRLEEASKLGTALVEQRKDLEDKLREVEQQQEEGQIGEELRRKLADLEREYNEIGQETARAFLAPKRLAGGDDGHLGTPSMDQKSPLHSALFAGQATNSPSKVSVPSRKSRNQSNRVHDIEFATEISTSLLAQVRQLQSLLAEREETLKTVNLEKSRLELEAEGYAQRIRALDESEERYKDENWALETKIHELMAAVKDVTDRETKLTSSLGAATAEKSAMERELEDLKQANAKLIEDHTAAQKANDAEINTLRRNLSAGDAERLTLQRKLEDMNTQNQELAKAVAMRLRQQEAESTREVVRPHDSEDEEQATPENSPPPSPNKFTPRHNHLETETLRSSLGHAHRMIQNLRSTIHREKTEKIELKRMLQEARDEVEQRRRDSVAANGPTNKRQKTKAETRKPARPDLLGAGRKKAEVEIHDSDWESNAGDISPTHKASNDSRDRRGDQPIDDRSDAYHTATEADDPFETANERETTTESEAFQTGVESMAGDSTDSDELTETEDRVQRTPRGRVSSMTLAKARDRTSYYSTASTSADEGDSTDPGTPSISQFSTPRYRLRKKRSVLRKIRPSGEAPMAFNSRPSSARESPSTSFTRDTSAAPEGQSLFAELAEVDGDEDDFGPPMQFEAASPSTPRMLPGFDSRRPSAVTVELPSKPDMVDSGVMTDPWEPNLHLASQTDDETVISVPVTPDKPTMSDASTGMDVVESPSLVHSSTQWTPLKPNAETSDDHVLSVPTPPKMAWDGQTLNEERKVDIPDSPTTQRELNISSVSFEETEPVAPSFPELRTAFFVGSTTEPVAAPVPVPPEVALSPISSQTTQPTEPVIPAPPEPEPIYVPEMAFSQILVEDTLPILAKLPEPAPERVFAEQGTSTDIAELSVSAISSEQTEPVEPVYEPKQDVAIVAEAVPEGPLSFVEQGTNTDDVEISFPAISSVETEPVAPVRETKDDVPEPVLSLTEQGTSTDTVEFSVSSISSEETEPVEPIREAKEEAAAVDDVASESTHPVLSIFLTPPAYTEPTAPKLQEAVIPPAPQLALSTVSSVETPPVQYTPDVLILPTPPALDENTPPSVMASTAKATKSAPPLVVVDDNTDKGTADGLVTQQNGVTLPLGAISGNAAPRRARSGSSNQADQGAQTILSSKQIDQLLIDRASVRPLSPPDSDKLNEMSNSPFATPKARSRPVPQASNASLHKRPGSAASQASSVQIHPPLPADHKEAIMAAEKKSIDQRPASAGLMGPPLAPASAVRASSQQRPRTPNESALQVGSAKTTTSRASVRRDSHMSRRSSVSSFASELEERFNMQPNPPFAPQGYSTGTDPRMIQAITQTMIGEFLWKYTRRAVSGEISNTRHRRYFWVHPYTRTLYWSEHDPQSAGKSEGRTKSVSIEAVRVVADDNPYPPGLHCKSLEVVSPGRRIRFTATTSQRHETWFNALSYLLVRNGPEDEEAENGVTLDDIDEFNPGFRSRSRQTARMSVSSSQSRGTRGLPKQRSGSAMSLRPSVTPGRASPYPPSHYSDQARQASSSRLSTIFNSTIKGSFGRKGPYAASSLNEDSIHNHDDSVEDLRHMMDRGDDVDRLENVRACCDGKHDVSSLSRTSRYSPRANRIHSHH
The following text describes a protein:
Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Miscellaneous:
MISCELLANEOUS: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
Subcellular Localization:
Mitochondrion.
Sequence:
MNLIFTRIIRRFGEGKRKTPFPGDPILVPDEPYDSKIQESQLSPMPQIDAKLINHLERLSLVRFDSEQAVANLRSSIRVAKRLELVDVEGVEPMHTVWEDQECPTFEDVEEDPLPIEEVFRNASLRFDDFFVTPPGNLPLESKERFDLNVINEWDTIGKPVAPEVKLTRMTERKK
The following text describes a protein:
Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular Localization:
Nucleus.
Sequence:
MKDFDFNADKVLAKDFLSNFADANGEAKYMNVLQDVANHRSRAVQIDLEDLLNPTEPFPDYDHDILMTQRSEDATENSEGSDPQQKMPAEIKRYYVVYIKATSKGRPFTTREVKASYICQLVRISGIVTWCSDVKPLMQVAVCTCEDCGFEIYQAMTSKFLKFQEAKILELAEHVPKGHIPRSMTVHFRGEHTRKVSPGDVVELSGIFLPIPYTGFRDLRAGSVADTYLEAMSVTHFKKKYEEALFLLVGAPHQKLKNGMKIRGDLHLCLMGDPGVAKGQLLKHIINVAPRGGVYTTGRGSSGVGLTAAVQKDPVTNEMVLEGGALVLADMGICAIDEFDKMDESDPVCIAKAGITTSLNARTAVLAAANPSWGRHDQRRSPAENINLPPALLSRFDLLWLILNSADMDCNTRLDSGIGIPTFRRNLQYPALDFTPLEPSILRAYISAARRLSPHVPKELEEYIATAYSSIRQEEAKSNAPHSYTTVRTLLSILSYQLCSQSLYVLALASLRFSETVAQSHMDEALRLMQMSNEAQLKECLEEYAALNVSQIHPHTFDIRFIDA
The following text describes a protein:
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence:
MTDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIATERATDLTVAKLDVDTNPETARNFQVVSIPTLILFKDGQPVKRIVGAKGKAALLRELSDVVPNLN
The following text describes a protein:
Function:
Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle. The DASH complex mediates bipolar kinetochore-microtubule attachments and facilitates the formation of additional interactions between outer kinetochore components and spindle microtubules. During chromosome movement along the microtubule, it is required both for the sliding of kinetochores along the lateral side of the microtubule and also for microtubule end-on pulling on the kinetochore. Modulates cytoplasmic microtubule dynamics by tracking the plus-end of shortening microtubules and slowing their depolymerization.
Subcellular Localization:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton. Note=Associates with the mitotic spindle and the kinetochore. Kinetochore association occurs only during mitosis. In the cytoskeleton, localizes to cortical microtubules (Probable).
Sequence:
MLQARIEEKQKEYELICKLRDSSNDMVQQIETLAAKLETLTDGSEAVATVLNNWPSIFESIQIASQHSGALVRIPPSTSNTNASATEQGDVEEV
The following text describes a protein:
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
Subcellular Localization:
Cytoplasm, cytoskeleton. Nucleus, nuclear pore complex.
Sequence:
MATPQQPEESLAAQIKSVDMSDDMSDEAIEVCRQAMAKHSVEKDIAQYIKKAFDEKRGPTWHCIVGRNFGSFVTHETKHFIYFYLGHCAILLFKTQ
The following text describes a protein:
Function:
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Sequence:
MAKTLGLHILADLYGVDADKIDRVEDIRELLEGAVKYANLTKISSHYYQFQPHGATGVVLLAESHISIHTWPEHGLATVDVYTCGDPSKAYRAMDYIITQLNPKRIDKQVHERGIVEEESNQSEAEKLRSILLQV
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKDIATPGRTTEILKKYGFLFKKSLGQNFLIDSNILTRITDTAEITKETNVIEIGPGIGALTEQLAKTANEVVAFEIDQRLLPILDDTLSAYNNVKVVHGDVLKADVEEVIAEQFAKPELPLKIVANLPYYVTTPIILKLLHDNIPADSMTFMLQKEVADRISAVPSTKSYGSLTIAIQFYMEAELAFIVPKTVFMPQPNVDSAVIHLKRRKEPLAEVNDEEFFFEVTRASFAQRRKTLWNNLASKFPALKPRKDELVEGLNAIGIDLIRRGETLDIPEFAKLSNFLGDFLKEK
The following text describes a protein:
Function:
Functions in floral reproductive organ identity in the third whorl and floral determinacy specification by specifically promoting the processing of AGAMOUS (AG) pre-mRNA. Functions in association with HUA1 and HUA2.
Subcellular Localization:
Nucleus speckle.
Sequence:
MERNSVKFHAEKRSGAFDPGSGFGSSKRVKTHHTQLLSALVVPVGHAAFRLLCPLSHVGAVIGKSGNVIKQLQQSTGAKIRVEEPPSGSPDRVITIIAQADSKSRVKLGANNNGNAEGEKKEEEVEVSKAQGALIKVFELLAAEADSDTVVCRLLTESSHAGAVIGKGGQMVGSIRKETGCKISIRIENLPICADTDDEMVEVEGNAIAVKKALVSISRCLQNCQSIDKVRMVGNRPLEKEFQASLHRPIETIIQESLPRSVEVNPYDYRLRNDEIFPRGTVARANDVIPHDTLHLRRIEAVPQGALRMHIEADRQDVLRRHVEADRQDALRRRIDVVPQETLYMPSDVLRGDCFRQHRERDDSHDSLHRPFEMVPRDAMGMPFESFPRDAYGRPIETMTQETLRGQSADYLAHRYSTLDTHPHSFTTSASMANTATMKPPPSEVEVGNQDVVFKILCSTENAGGVIGTGGKVVRMLHSETGAFINVGNTLDDCEERLIAVTASENPECQSSPAQKAIMLIFSRLFELATNKILDNGPRSSITARLVVPTSQIGCVLGKGGVIVSEMRKTTGAAIQILKVEQNPKCISENDQVVQITGEFPNVREAIFHITSRLRDSVFSNSMKNSLAKSSSALTTERFYDRQSDNPLSIGSHQSVSNPATNSSSLHRRSEDSFLSGSHSSVNYSRSVGTDPYIRPEDPFPDRFNPSAGYSHNFGRRFTMDHSDNSHHLTEAPSRLWASPPPAAPRGLSDASGGLSSARAGHVLGSGHKSAIVTNTTVEIRVPANAMSFVYGEQGYNLEQLRQISGARVIIHEPPLGTSDRIIVISGTPDQTQAAQNLLHAFILTGETSLSKKYNLN
The following text describes a protein:
Function:
Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles. By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles. Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Sequence:
MKRDGGGDLYWTRPECQVWTVMLLLGTCLLYCARVSMPICALSMNEDFGWNKKQSGIVLSSFFWGYCLTQIIGGHLGDRIGGEKVILLSACAWGFITALTPLLSHLSNAHLVLMTLSRILMGLLQGVYFPALTSLLSLKVRESERAFTYSTVGAGSQFGTLVIGGAGSLLLDWYGWQSVFYFSGLLTLLWVYYMCRYLLNEQELILSLGVLAKGFPMSKQMKIPWKQLFKKAPVWAVIFAQLSSASSFFILLSWLPTFFQETFPDSKGWIFNVVPWLTAIPASLFSGFLSDHLISQGYRTITVRKVMQVIGLGVSSVFALCLGHTSSFCKSVIFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVYLGGYLIETTGSWTSVFNLVAVVSNLGLCTFLIFGEAQRVDTISGYEDLYTTAQWYVRSAGGPR
The following text describes a protein:
Function:
Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MNEEDDRGRKRRPHSPETVTIKQERISPVRQHRTRRTPSPRSSDGGSPHRHQGRRRSRSPSKRKNKSSVKRSKSPKKKRHRSDSRSPPPLGVKIKQEKIEHSQRPYKERQRTERGQEDHRRNRHRDQADQDRYNHPRARDREQNREEQNLREQREEREFYNERRRERRQQNDQAEEEQTEDVDDSTDKGDANKEKPNFELSGALLEDTNTFRGVVIKYSEPPEARTPKKRWRLYPFKNDEALPVMYIHRQSAYLLGRQRRIADIPIDHPSCSKQHAVLQYRMVQFTRANGTSGRRVRPYIIDLGSGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVVLHESSDTSEVDKKQDDDDDEDEEDEGTDS
The following text describes a protein:
Function:
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous:
MISCELLANEOUS: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Subcellular Localization:
Nucleus.
Sequence:
MSSQSTTIAAPIVPLPLVVARLYSVYVKGEYMDFLLNDDHQKSGLVLLITSQMAPVLHILGLEAPSLNMPSRDLVDSVNDLNTLVSDFHRNAPNYSFGDFSLDYCTTDTLLAILEISKRCADVGSLRGGATGAKVFGNLSVRQIAVTCGELNIGEKDRFIDIGCGYGQLMCTVAALTQAEMSTGIEYQKHIYDAGVLHLQFFKNLMKFFGKRHGNIKIEYGDVTEEKNHSMVTSSTFIFANNIAFRDLNDQLKKIFLNCRNSTQIVNELFKICKVRSVKEKQLEVVKKNTDWKTKSTVLYLITINRKVLEKENEPVEKMEYEEAASGNVQNNTVPMDVVYRGNEKKKDDCGRKSTRIARRPFSVKYKTQKVQKSKRIPPQKPIKLRKPACETMVPCQNECCITKMKFSKKAGRYQFVLHAFIHSENQFDTFWDCNVCGFRCGSFQRCRDHYKNHHRGTLRTGYNISRLLQTFPKYKDHFAACFGDHIEL
The following text describes a protein:
Function:
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MASVLPLLLLWAFAPTVVPEVLSPEDVTDDLKALQVSIPRHPALHAVLAGDVTIPCLITYLAPLPTASTAGRRAVLGAPRVKWTFISEGREAEILVARGERVKVSEDYRLRASLPVFQQRYTDASLLLTELRPNDSGIYRCDVQHGIEDGHDILDLRVKGVVFHYRGGSTRYTYTFAEAQEACTAISASIATPEQLYAAYLGGYEQCDAGWIADQTVRYPIHTPREACYGDMNGFPGVRNYGVVDPEDMYDVYCYAEDVPGEIFLETAPDKFTLEEAAARCRAQGAVLASTGQLYAAWSAGLDACNPGWLADGSVRYPIVTPRERCGGALPGVKTIFQFRNQTGFPDAQSRYDAYCYREGTNSFPEAAGKYQAREPEGLQEIVTVAEKLEELQLPKAQVEIESRGAIYAVPFFKDVADAELEKPSLSPEDTRHPPVDASSSSARGHHPSSAAPFPTAPAVPKAGVPHSCAAQPGSPSPADQDGATGKGGRCAEARQEPSRTEDGAALEWPLGSVLGEDFGNTAAESPGRGQEPGQPMKPNVQTLLVGTEGPSDALSPAVAAAGDTEPPNGHPRPPVSIVPTCLPVHLWEAVGWPAHSGRASGQRDSQVTPPTRATFVTSTDIQEPSPSIGSRGAGGASTPIHTAGAAEDPELSGDVTENPGASPLPPAPPQLQDDGEEQSGAPWLSSPTAPGDGGTAPATAVTPWHAEVPGSSDALQTPSTDRGMPAASSEEEEDEEEEEDEEERPMPSVATVEGFLAAIPGEPGGCIPNPCLNGGTCIEDGTHPTCLCLPGYGGSSCERLLKRCSPSWDSFQGACYKHFSTRRSWEDAESQCRNFGGHLATILTPEEQDFINEQYREYQWIGLNDRTIEGDFQWSDGSPLLYENWHPGQPDSYFLSGENCVVIVWHDGGQWSDVPCNYHLSYTCKMGLVQCGPPPTVSNARAFGKPKQRYEIGSITRYHCRHGFAPRRSPIIRCREDGIWERPQLSCRPGLARHPED
The following text describes a protein:
Function:
Metalloprotease.
Subcellular Localization:
Secreted.
Sequence:
MLPSLVLSILLSAPMALCQAPFWMPNMQQFSFLTETDFRNALLLPTTNTRRVRSLFHDMRIPMQRFKRGGGVAVAADKDKWPNGRVPYILSAAYTSAQRAVLARAFDAYAKRTCIRFVPKAPTDKDYIVIQKLDGCYADFSRVGGRQQVSLADECIDYATIIHELMHVIGFIHEHQREDRDQYVSILYQNVIQGANTDFDKLSNLGLSYYGEHYDYTSIMHYEANEGSRNGKNTIEAKNNHFTSIMGKANDFSTSDLRRVNRAYKCSIF