lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPAKKRQNDSETGKKNKKEKRGELAAINADLKEDSVLKSMRDAWQKKRSFSNGCVQLDCEPFPHCQITDFLQSPSFVEGLQAELLQLNFNSKSNDLYKFQQSDDLKERKEHHISQIRSIIFGEFRVWLSEVLQVDLEATVDISCAKYEHTDVLLCHDDELEGRRVAFILYLVPPWECKDGGTLDLFNTDEHCQPMSVVKSLLPCCNSLVFFEVSPVSFHQVAEVLSEEKCRLSLSGWFHGPSLPRPSRYIEPSAPRHAHIPRDETLLFEWVNEMYLDPRYQARVQQEFEDSSEICLPSFLQEEKLRQVRSALQSSEIQWEKRGPPNKRCYSCADLQSIPSCVQECWELLSSEAFFILLSNLTGLSLHYLCTNEDDGENEEGKSETENRDTEGDAQAGGSSTEADASSRENKKDKGPPSCVGEVRRWAHGDYTLLHDSVKREYALDLQLHMGCAGWKAEFGGFTSYIAHDEDEELLTVYPEDNSLALVYRDKDTLKFIKHINNSSTSHTTAFYDFSFNYFES
The following text describes a protein:
Function:
Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle.
Subcellular Localization:
Nucleus.
Sequence:
MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIRALLTGEEQSKPQQNSSRHPKAGKTDANTNSLVGN
The following text describes a protein:
Function:
Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules. Modulates both rotational polarity and anisotropic cell expansion during organ growth. Promotes clockwise root and etiolated hypocotyls coiling, clockwise leaf curling, but left-handed petiole twisting.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MGREVVEVLMDRNADVSSARVHVAPKIAAEETDEEFEVKECTEEKSLSENAPNVGSAERVGAQKSPKTRNGNAKVSKQDAPLLAVRKPLQPENKKHIDDEDNCSIASSVATSMRMGKSGLTYGSAPTFRSAQRAEKRKEYYQKLEEKNQALEAERNELEQRQKDEQEAALKQLRKNLKFKAKPVPNFYYEAPPAKPELKKLPLTRPKSPKLILSRRKSFSDAVSSSSREEILKTVSNRNRHSTGTVQNKDDDHRNKNTNAAHDSPRVRSGKGKSGLKPVNESSEEA
The following text describes a protein:
Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MVEIDFNKENEEDFSDPPGFVDDVTDDVLVPDVLHKKPTIDEFEDNCVFIAGIPVVGADRLGKLQSVLKKVLERLDPAVKLYIPPSPEGGCLGVLLTEWADQRSAQFAVKSLNGYAFDKNHTFTARSFKDMKQLEAPSDHWTTPEKQAYNDVGDLWWWLQNERCRDQFAISHDKLGVPTVGVFTNMKGNDPELAGDADKAERANWTETVFTWSPHGSYLSTIHKQGIILWGGKDYARAHRFAHTNVQYIDFSPCETYLVTYAAPEESNSWGDCEKDSLRIWDVRTGELKKAFSTFELTGRTQLPTWPFFRWSFDEKYFACLKAPEKDKLEREQKINGISIFESEKFELYEGRPVNIENIKQFEWSPTSTVLAYYSECTDAVPAEFGLLQVPSMQRLRSARVHNVADAQMFWQKSGKRLAFYTMRFKKKEYRETGEVKYVGGCQYHVDIFEIDKKDVSLMNLPLSEPFIHFDWDPEGDKFCVLVGNTAKATPQVYKIEANSHAPKLVSKLDAGVHFNEVQFAPKGGWLAVLAKVSAGGNVYFIDTSLSEAKRTNVIEHPLFNKGYWDPTGRYFVTCSTLGGRAGADLGYRIFTFQGRELCRKNLDRLAQFKWRPRPPVKLSEQKQREIKKNLKKTAAKFIKQDDDEKCRASQEVVEKRRKIMAAFDIIRSRNREQLDATRDERISLRNGVDTEAQLDEDEFVDEEITIALSTSKTQAPLTEEEMRD
The following text describes a protein:
Function:
During stationary phase, converts 70S ribosomes to an immature dimeric form (90S ribosomes) which are converted to inactive 100S ribosomes (a process called ribosomal hibernation) by the hibernation promoting factor HPF. Inactivates ribosomes by covering the peptidyl transferase (PTase) center of the 23S rRNA and the entrance of peptide exit tunnel. However crystallization with T.thermophilus 70S ribosomes shows it binds near the 3'-end of the 16S rRNA near the anti-Shine-Dalgarno sequence, where it would sterically hinder translation initiation. In this crystal binding of RMF induces movement of the 30S head domain away from the rest of the ribosome, presumably so they would more easily form dimers. Also involved in protection against heat stress, but this role is not dependent on the maintenance of ribosome dimers.
Miscellaneous:
MISCELLANEOUS: When cells are transferred to rich nutritious culture medium, RMF is quickly released from 100S ribosomes, which dissociate into 70S ribosomes. It indicates that this interconversion is a major system regulating translation activity during the transition of growth phases.
Subcellular Localization:
Cytoplasm.
Sequence:
MKRQKRDRLERAHQRGYQAGIAGRSKEMCPYQTLNQRSQWLGGWREAMADRVVMA
The following text describes a protein:
Function:
Catalyzes the phosphorylation of erythritol to D-erythritol-1-phosphate.
Sequence:
MSAMREKGDIIIGIDAGTSVLKAVAFDFSGRQIESAAVRNTYVTGDHGAVTQSLAQTWQDCARALRDLGAKLPGLAQRTAAIAVTGQGDGTWLVGKDNRPVGDAWIWLDARAASTVTRLAAGPMNRARFEATGTGLNTCQQGAQMAHMDTIAPELLDNAEAALHCKDWLYLNLTGVRATDPSEASFTFGNFRTRQYDDVVIEALGLQKRRNLLPEIIDGSQSQHPLSAEAAAATGLLAGTPVSLGYVDMAMTALGAGVCGGTAGAGCSTIGSTGVHMRAKPVADIHLNKEGTGYVIALPIPGIVTQVQTNMGATINIDWILQVAADLMSTPEKPVSLGDLIPRLDDWFNASRPGAILYHPYISEAGERGPFVNANARAGFIGLSSRDRFPELVRSVVEGLGMATRDCYAAMGEMPAELRITGGAARSKALRGTLSAAVNAPVRVSAREEAGAAGAAMMAAVAIGAYPAMDDCIAEWVEPLLGASEAPDAARAHQYEELFVAYREARLALAPVWDKLASGK
The following text describes a protein:
Function:
Has weak lytic activity toward S.aureus cells.
Sequence:
MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVTKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
The following text describes a protein:
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sequence:
MASGLQVFGQPASTDVARVLTCLFEKNLEFDLVRIDTFKRQHKLPEFVRLRDPSGQVTFKHGDKTLVDPRAICRYLCTQFPNQGNRNLYGTGSLERASIEQWLQAEAQSFNPPSSALVFQLAFAPLLEIPQDHMAIAENERKLQQVLNVYDEILSKNEYLAGDEFTLADLSHLPDSQYIVSSERGRKLFTSRRNVARWFDKISRRKAWEQVVKMQMEHPGAFE
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Sequence:
MAELPTPHSLAIATLISLHADPHSPLMSCGDDDDVYNVQQPPPLTTGDSARGGRAADGGQAGFRMRLERLLMELVLREDEGMVVVLPTPSTTRQNDGLFENPAEDRDDNYKTAPPPNRHSNSKGMDEDDFFAKHALDGGGDVLNDILGLFGGSLPCFDDDEINIDLFHKTQHQHKQQHSSNSSEMMNNNNHSTSLSFQMESLSTLLDRIDHAFSPSTSSNSTNTYRQQQQRRSPPSTHLLNTLTNHSTSINSLIDLLDNWHSLLSGEYYSPNNNTTNINSSDNGVMISIDGESAHGVYLRRVCLGMEELGFEAVSRLWMSLRNYLEKEVSNNCGGDCNTGEEKKIENGDYFFEGSSSDGGECWLPSNPQIERIVRRTCLAPNLDSLLRGQGTTSNSSLRSNTNSSAALSVQQQQHQPPPQTHNLLQTHPECPSLHFFLFLSSLANGDRSHALESLHRYFDYAMIHERKERAERAMMLQASGSTSSTNGGNIAAGNNEWGVTGMGGIITTMTSGMGGITGGMTGGQGRGGTSHSSGGNNNKYKESNVMQYAAILLAQMYHRFGYLELSIQATEEAIRVAQQSGDEECVLFAQSWLALSSSDGGGDGNASNRAGSVYATVGGLANGVGTSTNNRPLATSTFGNSSGGSFREEEMLMLQRCHSRAADRGLSSLAAGASLELARRAAYQRRGEEGDSSLGANDEQAEDVSSLAWESIQQLGRTSTSSATTNTGRHGMMGGQGAAATISGGVANTTDVDNMTASDALGVLGRQNMAISGLWDSTGHSSLASLSSCAALYGFGTELCEGDKSVAMRRVLSSFSYGPGFDAWSKHERGLSSCVYAKSLQQLSTLCGVGTHDLSPEWIQSATSTLHEWSVRSYDLSMAQGLQCILANQSAFPSDTLLAVETSLVSLTHSTHLHLRRGDYERAKVTTRRACWLASKHSLLFHQGWHLLQLALIDLEAYVTAPSTNPPVERALAPLLECLNLSEQYAMDPLRAVALTTLAKVMLDMGHFWKARAMLNAAMPLVMQHGHIWFQAEAFLIIAKCYLAEAASSENDQKEELRRTALFQLENSTTLFGQIEDIQRLRQVYYLQAIICQSLPNMKQKRNKVAKLYIQMSAQRLHRMSSASMTTPKANSNSMMCNVMQGIMVTDAQSLQRGISMKQQR
The following text describes a protein:
Function:
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Sequence:
MKKIVLYGGQFNPIHTAHMIVASEVFHELQPDEFYFLPSFMSPLKKHHDFIDVQHRLTMIQMIIDELGFGDICDDEIKRGGQSYTYDTIKAFKEQHKDSELYFVIGTDQYNQLEKWYQIEYLKEMVTFVVVNRDKNSQNVENAMIAIQIPRVDISSTMIRQRVSEGKSIQVLVPKSVENYIKGEGLYEH
The following text describes a protein:
Function:
Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Subcellular Localization:
Cytoplasm.
Sequence:
MNGKTPLALYIHIPFCSKKCHYCSFYTIPYKEELMRSYCEAVIKEGLKKLAPLRCSHYIDTVFFGGGTPSLVPPALIQDILVALEAQHATEITLEANPENLSLEYIQALALTSINRISIGVQTFNDPLLKLLGRTHSSSKAIEAFMLCSQYGFSNVSADLIYGLPTQSISDFIVDLHQAISLPIQHISIYNLTIDPHTSFYKHRKRILPSIADDDSLAEMALAAEELLENQGFTRYELASYAKNQAASKHNTYYWTAKPFLGLGVSASQYLHGIRSKNLSRISHYLRAAHQHLPTLESMEELPPNERIKETLALRLRLCDPIPFGVFPQELIDEILMHPSIGSLFTKDDKAFSLNKKGRLFHDSIAEEIMASSFSFSK
The following text describes a protein:
Function:
Removes the phosphate from trehalose 6-phosphate (Tre6P) to produce free trehalose. Also catalyzes the dephosphorylation of para-nitrophenyl phosphate (pNPP), but with lesser efficiency (in vitro).
Sequence:
MIFLDYDGTLVPIIMNPEESYADAGLLSLISDLKERFDTYIVTGRSPEEISRFLPLDINMICYHGACSKINGQIVYNNGSDRFLGVFDRIYEDTRSWVSDFPGLRIYRKNLAVLYHLGLMGADMKPKLRSRIEEIARIFGVETYYGKMIIELRVPGVNKGSAIRSVRGERPAIIAGDDATDEAAFEANDDALTIKVGEGETHAKFHVADYIEMRKILKFIEMLGVQKKQ
The following text describes a protein:
Function:
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular Localization:
Nucleus.
Domain:
The DBINO region is involved in binding to DNA.
Sequence:
MSGEDRGAPYRYAGERPPAYPADGYASYQRGLKSSIPSRSYDTAYPEQGYDRHLRERVHPAYTTGPSYGVPPPPPTDYRRPPPQAAYRYEEDYHHRRAPAQPHLEYAPEHRRQPVHSDAYREADDRRSFEQARSDPYASPSRHAYQDSYRSELPHERRHAPAAYERISVRDDARSAPENRHIDEPAVYRRDEYDAHSREIQPSYRRGAHRSPRLSPQPVVSAHERSSEYATRDYSASAARYAEPVHQPESPPRPSMSIFNMLNDRSANGAVESVHSSPTKSSIAAEHESYPTTAQEPSHASRAAFDPAREQSYSTARDSQAYSRGSEARAGAARVNYTVHPEDEAAISQRRNSSAHQQSSIKSVRHPANAVDEPLIRVKHEEATSASLDAQMSAEPPVSHTLNNGERLSAQDAKVATEDSSLAANGNGKVDSAGGTARPAPAKTQLKLRNNPLPASKSNSSFVAPPPPAKKNRDPDGWESDLSNEENQPFWQTELDDYIFDVRERQRLIEDAFVASMREKHVEVERRLARAYEGRYFAVIRQIRLREQQEASQRDMERRQDHVRQQRDHEIDLELLGTLSDGQQNMGTRKKKGGRGTDDDGLLQADDDDDDDSDDVALADLAARNGSKSNIIKLKRSKGKPAAADPRNKKRRLENGAALSPAPGSEVDSTLADFGGNFDGDDSAFASHQASPTPDDVSFALDVDASGKVPIDARRAQQLEDAHRRIWTTIAKRDVPKVYRTVLQSASSKTMYWRRISSVVQREAKRGAARNNKTVKDVQLRARKVMREVLVFWKRNEKEERELRKKAEREALEKAKKEEEMREAKRQARKLNFLISQTELYSHFVGSKLKTAEAEESEETAGSSKIIDPNAQPSDATVLPINPHSELADAEARLAELDDIDFDDEDESNLRAHAARNAQEAVRLAKEKAQAFDVAAAEERRRNEAAAREREGLDAGPVKQIEEKDLGKAFDSDDMNFLNPTSMGQTEIKQPKMLTCQLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISLMAYLAEVHDIWGPFLVIAPASTLHNWQQEISKFVPTLKALPYWGNVKDRAVLRKFWNRKQISYNRDAPFHVLVTSYQLVVSDEKYFQRVKWQYMILDEAQAIKSSSSIRWKTLLGFNCRNRLLLTGTPVQNSMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAEQKGTLNEHQLRRLHMILKPFMLRRIKKNVQNELGDKIEIDVFCDLSARQKMLYRGLRANISVAELMDRATSNDEAGLKSLMNLVMQFRKVCNHPELFERADVRAPFALADFARSGSLAREGDLLNLPDSTTSLIELQVPKLLVREGGIFDIPGHNSRKGFDTGYLQNLFNIWRAPHIHESLQEERSTFASLPLIGVSPSEAQKTFHSTGIKRILAAAAEERHWRSLEAFASDDTFAAASVRPLAKMLRPMPTTSGRSPSVLMPLEEVAADYRRHSYLAKDSARAVVAPAVAPPIKLYSNDGPFMQAQERFSRDAQVSVTLFGLSPEGRESVKRVEELQSELPEVPPQGVMRDSSIDQLPYNGMQVPQMNKLIVDSSKLAKLDVLLRELKANGHRVLIYFQMTRMIDLMEEYLIYRQYKYLRLDGASKISDRRDMVTDWQTKPELFIFLLSTRAGGLGINLTAADTVIFYDHDWNPSNDSQAMDRAHRLGQTKQVTVYRLITKGTIDERIVRLARNKKEVQDIVVGTKAYSETGMAKPQEIVSLLLDDDELAESMLRKKQAEEAQTAQEKADLARASHAKRRLNKDRAAAAVESPAPVGSTWSLEDDEDDFFGARPPSKADTDTAETTPQLQSKKRSVGGGGGGSGGAKRGRISEVASPRMTPLSLDDGALMASGEQLASPSKGAAAKRKSKSHRKKTVDELAGVDLD
The following text describes a protein:
Function:
Probable ATP-binding RNA helicase.
Sequence:
MDESSRKHMEDCFLRSPSDIRTTNVPAAPKSQAADNKSRKTELHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDRGRGGHGVKHSYWQDRGTLVVQSVQGVSSTRGNDSDGDRLRRYALAKLENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPPSEQEILDMRADEKEALESIFDKAYEEREANRVWNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRNFDRDGTCKYGPKCRFAHLPQQPTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEAPFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILKAHDLETAEMVQCLRAEMIKLLEEKIRDPCLNLLHHKNGCRMIANIVHLISKNS
The following text describes a protein:
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Sequence:
DSMNSSGYTFYEPCIPWRSRSSRIILYIFIIAGIICTVFGNFLVVLSIAYFKQLQSPTNSFVMSLAVADFLVGLIVMPYSMIRTIEGCWYFGPVFCEIHSSLDVMLCTASIFHLSCIAFDRYYAVCNPLVYGFKMSKTRVTLLIITCWVVPLLISFAPILLGLHKLGIETKLPHDVCYFLVNQVYAITASFVAFYLPMFIMLVAYWKIYKAAKRQAMQINAVENQMTIQNGAVNSTKKQKQRNSMKRERKAAKTLGIIMGAFLIFWLPFFTTNVIDPFIEYQTDMVIWEVFLWLGYVNSSLNPFLYGFFNRSFRRAFFMIIGCKICLPGSPPSIDLSN
The following text describes a protein:
Function:
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Overexpression reduces biofilm formation.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQADLVSDAAERYQGQVCTPAHQKRMLNIIRGYLYINELIYARDNHFLCSSLIAPVNGYTIAPADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPLFWSEVMSDDPTLQWGVYDTVTKTFFSLSKEASAATFSPLIHLKDLTVQRNGYLYATVYSTKRPIAAIVATSYQRLITHFYNHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCIGAEALLRWPGEQGQIMNPAEFIPLAEKEGMIEQITDYVIDNVFRDLGDYLATHADRYVSINLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFLDVDKMTPIILAFRQAGYEVAIDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEGVETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MSYYDIDAILTDAEKIPCTFQIDVPDLGYLDNQPGHTLKSGSRVALPIWLAEMLAIANTGAVDMDDPSQSSKSFITFDLPPALGNDVVQALKADPRSVPLRDQSAHFYALATHMMELSEEPELSAVLRKTFVSRAAEIALHARKVGGGGSSYHGRDGGGAGGKGKGKATKDDNASNLGVGGAGEDFLRGLDEWERKLFRSAHDGTKASKEWMENVKKR
The following text describes a protein:
Function:
Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.
Subcellular Localization:
Mitochondrion inner membrane.
Sequence:
MASTGVNVLRWSALGAGVFYGFYHQMSISSATKTAAAHREFEHKQKLIEQAKAEYAKKNLPASKKTGGDDIIRDPMDKNFDLEAYLKVLAAEN
The following text describes a protein:
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
TAAVVFLHGLGDTGHGWSDAMAMLAKGLPHVKFVLPTAASMPVTLNMGMRMPAWYDIKSLARVNGDNADGIDASRDRVMAIIEKEVAGGIPLSRIVLGGFSQGAALSLFSGYQSKTVLGGIISMSGYLPRYSSFQFEPETADVPLLMCHGERDPVVRFEFGKMSREKLEAAGVKNVEFHAYPDMEHGACMEELDGVTKWLQRVLP
The following text describes a protein:
Function:
Involved in pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MADNHQLEQEIPKEAQNERDGRAEEGGPSTGSSSLFKKRNKKISQNQIIRKRTIDSEPVTTTTTTNQDDPSLSQIKKSKLVHEQSNQEQQQPVVKFNRRKNQRNFNPLCQATLGSSKRSKADQSGSSSDEEEEDGEEDDDSKPRAVGVAYQAQGSARQQAEEAYQKAILEKRELDQHARQGLEPDQAEPEPGPDPKIYLGTSKSKYQLPKGSQKYGPIKGGPNNIKTITVVDYQPDVCKDYKETGYCGFGDTCKFLHDRGDYMHGWQLDDAFNSSRNKKTDGAESEEEEEEVPFACLICRQPFTDPIVTKCHHYFCSGCAIKRFAKTPKCFACGTPTGGIFNKASRIIEKMKAKQERIKRQKEERRLEEEGLAGIEGLETLPSADQALDEEEEGSERSFYEDE
The following text describes a protein:
Function:
Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as a non-specific GABA permease. Can also transport alanine and glycine.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVNILPFHKNNRHSAGVVTCADDVSGDGSGGDTKKEEDVVQVTESPSSGSRNNHRSDNEKDDAIRMEKISKNQSASSNGTIREDLIMDVDLEKSPSVDGDSEPHKLKQGLQSRHVQLIALGGAIGTGLLVGTSSTLHTCGPAGLFISYIIISAVIYPIMCALGEMVCFLPGDGSDSAGSTANLVTRYVDPSLGFATGWNYFYCYVILVAAECTAASGVVEYWTTAVPKGVWITIFLCVVVILNFSAVKVYGESEFWFASIKILCIVGLIILSFILFWGGGPNHDRLGFRYWQHPGAFAHHLTGGSLGNFTDIYTGIIKGAFAFILGPELVCMTSAECADQRRNIAKASRRFVWRLIFFYVLGTLAISVIVPYNDPTLVNALAQGKPGAGSSPFVIGIQNAGIKVLPHIINGCILTSAWSAANAFMFASTRSLLTMAQTGQAPKCLGRINKWGVPYVAVGVSFLCSCLAYLNVSSSTADVFNWFSNISTISGFLGWMCGCIAYLRFRKAIFYNGLYDRLPFKTWGQPYTVWFSLIVIGIITITNGYAIFIPKYWRVADFIAAYITLPIFLVLWFGHKLYTRTWRQWWLPVSEIDVTTGLVEIEEKSREIEEMRLPPTGFKDKFLDALL
The following text describes a protein:
Function:
Probably part of a binding-protein-dependent transport system.
Sequence:
MKKVMMLALALGASTSLAAPFVYPANWTSNKPGDVQTGGTFRSVNLQDFKTLNPFVSSESPNLPAVLSAGSLLGYNPVTGNYAPYMAEKYTQSADKRTFTFDIRKGMKWSDGKPITVDDWITAYTIDSNKDVGSNTFDYWTINNQPIKVTKVDSNTLKVVFPKADVTAIEFLSGIFLPQPTHVFMPVWKAKGAQGIKDMWTISTNPDNIVTSGPFMLDRYVRGERAILKKNPYFGEWNKDSAGKSLPYLDGIQINIVADANAQLAQFLAGNLDTYSPDNRDKLAQVKSAMDGGKVKGTLIPNASARASSDFMVFNMDDSATFKTKLFSNVKFRQAMSMLMNRDAMVDLALGGLGEPTYTSVYPVYKDWIPSGMDKYKFNPTAAAKLLAELGFTKKGSDGILVDKAGNKLEFTLITNAENNRRQSYAKVIQDEAKKVGVKINVSAIAFNQMTTLLDAKDNFGRRNFDAIIIGLTGGGQVYPVSGPSVVECKGLGDGGNLHMFNQSNKCRFPFETQAVNLFWKGRAEFDLAKRKAIAAQIQRNEMENQPYIQLAAQTVHFAWTDRVQGEYNRPQINSLNASTLFGPRDIALTWIKR
The following text describes a protein:
Function:
General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.
Subcellular Localization:
Nucleus.
Sequence:
MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Subcellular Localization:
Cytoplasm.
Sequence:
MERTIGIDAGGTLTKIAYFNKKKLLTFEKFYSHEQHKIIDWIKNNNGIKQICITGGKSKLLQQLLTGSYKIIELSEFEATLAGVQFILKEEQHTINNFILTNIGTGTSIHYVYNEQYIRAGGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKELDITVGDIYGGILSPIDNNLTASNFGKAAITESNNSSSDILATVQGLVGEVVTALSLQFAETKNIEHIIYIGSTLCNNVQLQHIISSYTEYQNKTPIFLQDGGNSGAIGALLHATK
The following text describes a protein:
Function:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytosol. Mitochondrion. Nucleus.
Sequence:
MGNTKGLVHNDPKLGSAMDDLPFRFFQFFVMSTLRIDLLQPGRILCSLKVPARLINDNNSLRHGASVFLVDTLGHAAVKTLGPPSTGVSLEVNVSFFDAAYLDEEIEIDSNVLRLGKTIAVVNVEIRKKSNGKIIAQGRLTNYTPVSSKL
The following text describes a protein:
Function:
Required for development of the heart, potentially via cell-cell adhesion and modulation of expression of cardiac precursor genes. Plays a role in desmosome cell-cell junctions and their intracellular connectivity.
Subcellular Localization:
Nucleus. Cell junction, desmosome. Cell junction. Cytoplasm.
Sequence:
MLKPHPEHKEQPQDSFTPSGDSTPDASMAEERDFMRSVLPVYDSFHPEDSSLALPLANKLTLADAHRLNRLQQQVQLTLSRKKRKPKPADSSLAESQSSCQISSSSSLGSLHLKRTFSVNHEATRSLRMVDRSQWPSMEPPLFHRGYGSFRYTPKRAGLCLGSNSLTLPSAPTTSHFQMNKLPLRYAHSEVLRNPRFAGLSAATQIPSSPVYENPHTDDTDDVFLPSTSVERGRMESEKHTLQQTLCKQREGGFVALEQSENVSWQSRVRKPSLEFVAGRRPSQTGSLISMEEQSGSLGRIEKLEVKQHAVTTLTKKGKPGELSAEMTLKEAVNLLTQDNNMETQIAAANFIQNQCFNSPDAKRKILHLQGIPKLLKLMQNDSEELQWAAVSSLRNIVFENNENKMEVKDCEGLPVILRLLKINRDIETRRQLTGLLWNLSSHDLLKEHLSREAVKPLTDSVLVPCSGISEGEDPKLELLADPDIFYNATGCLRNLSSAGPDGRKVMRDCEGLIECVIYYIRGTIADYKPDDKATENCVCILHNLSYRFDCEVPRVDSPVAQKPKQTHTETSNPGCFIIKTPKNSAENLEADEDYPALEENGSPHGVEWLWSAITVRMYLSLIAVSTNQHTKQASIGTLQNLTACSGEISQAIAHFIVQKEGGLSQVKKLLQEAEKEELRISVSLLKNISRYRELHADIVKQVLPELVAILPNSDRNVEQPIEITVTICHILINLSQASASNTCAIINQGALPKIISISSKDNGFGPTRAGQAACVLLHTLWRHSELHSSFKKAGYRKTDFINNRTVKAVNSARE