lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases.
Subcellular Localization:
Cytoplasm.
Sequence:
MATPCSSSRLRYLIHLAHDNVDFRLPEIKALLALRGKPFHPCENFNEQSPFWCLEGLSEEDVRSVMARSVCAKSAFELWGHGQTDGNLRSSLLNYPPQSMSPFMHKDSTYRINVYTFNKTLQFQDRIKKIDALDYLPFEGTVSLKTPQHIFCLLEDYGTDPNNIPEDPNYIYFGRWIADGQRELIRTHSVKNRHFIGNTSMDAGLSLIMTNHAKVKENDLIFDPFVGTGSLLVACSHFGAYVCGTDIDYNTIHGKGRSSRKNQKWRGPDENIRANLRQYGTEKMFVDVMVSDASKPVWRNAALFDAIITDPPYGIRESTRKTGSYKENTKLPDCTYVESHVPVSQAYHLSDIFTDLLNFSAHHLVLGGRLVYWLPIYRPEYCDEMVPVHPCLQIISNCEQMLSSQTSRRLITMEKVKEPEESDIIAHLSDPHFSAYQGHNAFREKYFSGLNKRCGKEDTKYFNKN
The following text describes a protein:
Function:
Methyltransferase which catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Sequence:
MALTGQSTDDQAVLDAEHELWTTTFSYIKSMALKSALDLRLADAIHHHGGAATLPQILSRVAVHPSKIPCLRRLMRTLTVSGVFSVVQQQDVVVPAAPVNNDTGTYTGAEPSYTLTPVSRLLVGSQKSGSIMAFVLSPVLVAPFLGIGAWFQHSLPDPCLFEQAHGEALWEMSGHDAALDALINSAMVSDSRFIVDIAVRESGDVFRGISSLVDVGGGLGAAAQVISEAFPHVECSVLELEHVVSKAPAGTSVKYVAGDMFESVPPADAVFLKSVLHDWDDEKCVKILKTCRKAVPPREAGGKVIIIDIVVGADKKHGEVHALLDLYIMFINGVERDEQEWSKIFLEAGFSDYKIIPVLGFRSIIEVYP
The following text describes a protein:
Function:
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMLVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
The following text describes a protein:
Function:
May play an important role in the progression of epithelial malignancies.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MAPAAWLRSAAPRALLLPMLLLLLQPPPLLARALPPDTHHRHAERRGPQPWRAALLSSPAPAPATQEAPRPASGLRPPRCGVPDPPDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGHADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDRRGIQHLYGQPRPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDARGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
The following text describes a protein:
Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Sequence:
MLSGVLRIYLDIEADIRALQLDSAEENNGVGVVIPTDQNSDGVEIVDKMDEDLKDEVQESVPAPDVQQAPEDHDQEILHPVHNPAKAKEKAAQEKAAKEEAEEEAEANKKRHLNVVFIGHVDAGKSTIGGQILFLSGQVDDRQIQKYEKEAKEKSRESWYMAYIMDTNEEERAKGKTVEVGRAHFETETTRFTILDAPGHKSYVPNMISGASQADIGVLVISARKGEFETGYERGGQTREHVQLAKTLGVSKLVVVVNKMDDPTVNWSKERYDEIEQKMVPFLKSSGYNTKKDVIFLPISGLMGTNIDKSMDRNVCPWFSGPSFFEVLNAIEVPPRDPNGPFRMPIIDKFKDMGTVVMGKVESGSIREGDSLIVMPNKEHAKVVAIYCDEDKVKRAGPGENLRVRITGIEDEDILAGFVLSSTVKPVPAVTEFVAQLQILELLDNAIFTAGYKAILHIHAVVEECEIIELISQIDMKTRKPMKKKILFVKNGAAVVCRIQVSNSICVEKFSDFPQLGRFTLRTEGKTIAVGKVTALSGASSSA
The following text describes a protein:
Function:
GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel.
Subcellular Localization:
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence:
MSDSKMDKLARMAPLPRTPLLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYKWNEGPNSVGVSSEVSLPQFKVLGHRQRAMEISLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVVISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSDVVADDLVLLGEE
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MSTLQYMKEIISKQITTLSNPNGEDKKTLESEPYHNLQKSSVLLESRCFNDPQLQDKKCRQILSKLIYLINQGEKFNDQESLSLFFGITKLFSSNNVDLRRMIYLMIKEFKDENSMYVVISCLAKDITSKNDLFRINALRTLPYVLDQSNLVQLDRYLKNAILEKSQPISSAALIAGLQIFRISPDFIRKWTNEVADRLNSKYPQNSFHALLLLHEIKSNDKVTFTKILTGLTKETLVPIANMQVIRFIKEILNTDDLDQQYEKLFIEYLLRQIHKSQEIVIFEACKALCDLKSLSNKDLQPMVQVVIVFLQSSNVINKFVALKILNRLISNPIRRSLITPSQIEPFIQDSNKSLSSLAVSILLKVCQEGNIEKILVQIFEYLNEMSDEFKIDVIRSIKALVKSSPTKWKSIINFLKLTFKCDASQEFKKYSIEIFELIIHEIPEAKEHAILTLADYIEDCQHASIQLSVLSILNREAAKKQCPTRAIRIVNNRLYLEDAEIRAAAVGVLGKFLLHYPNEKDNLLELLSAAAYDPDEEVRNRSQFYINESAAPKEENPPLSIEELDAIEAYLQQNIQEIQQSNEEVLQLEKIMAYAEQNKGKIKKTEVLQELVEEELIQTHESESGFETYKKLFKESTIFCDYGVLRKSSRAQNLTDSKCEYLVTVVKHFFDNHIILEYKVKNTLDNVTLNDVSLELTIKNVNLQFERIVPAKQIQPQCASNILVGLQFNPNLRLVSSNIQSILTFTVNENGTTYQDEYQTEDFTITYSDFFLPIQWFKKFQTEWESLKSQEMSATYQLDYKNTDIAIKELVKHFGFLVCDNSDQIQPQNKFHTLLLSGQYLDAKNALVICQIGFQQNIGCVLKIKCKSEDDNLSTNIVETLG
The following text describes a protein:
Function:
Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis.
Sequence:
MAIRQISRQTLALLFVVAAASFAALVFADGDDVVVLTEGTFEKEVGQDRGALVEFYAPWCGHCKKLAPEYEKLGASFKKARSVMIAKVDCDEHKSVCSKYGVSGYPTIQWFPKGSLEPKKYEGQRTAEALAEFVNKEGGTNVKLATIPSSVVVLTPETFDSVVLDETKDVLVEFYAPWCGHCKHLAPIYEKLASAFKLDDGVVIANVDADKYKDLGEKYGVTGFPTLKFFPKGNKAGEDYDGGRDLGDFTKFINEKCGTSRDTNGQLTSEAGRIASLDTLAKEFLSVASDKRKEVLSSIEEEVAKLSGSAAKHGKVYVTIAKKILDKGNDYTKKETERLHRILEKSISPSKADEFIIKKNVLSTFSS
The following text describes a protein:
Function:
Activates transcription. Positively regulates PcrtB promoter upstream of the crtB operon in a cAMP-independent manner. Regulated genes include genes encoding DNA photolyase, phytoene synthase and cytochrome P450 monooxygenase, which are involved in carotenoid biosynthesis. Positively regulates the light-inducible gene cluster in the megaplasmid in a cAMP-independent manner.
Sequence:
MKRFARKETIYLRGEEARTLYRLEEGLVRVVELLPDGRLITLRHVLPGDYFGEEALEGKAYRYTAEAMTEAVVQGLEPRAMDHEALHRVARNLARQMRRVQAYEAHLQTGELRARIARYLLFLADTPLSARDRQGIYVTVSHEEIADATASIRESVSKVLADLRREGLIATAYRRVYLLDLAALEREAGSALEAA
The following text describes a protein:
Function:
Intake of glucose and galactose.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MGNNQPSARKKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFIFVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILKANDSELFALIESGALDEATKNAMLNELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEQNATDEQDNKHTDKKSILDFPYLILGALAIFFHVGTQVIAIDTIINYANSMGMDLLEAKVFPSYTLGCTMIGYILGIILIPKYISQKNALIGCTLLGLALSFGVVWADFDMTLFGHQANASIFFLNALGFPNALIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVYGHFADQYSLRIGYWVLIPCFIYLVFFAIKGHKINSWR
The following text describes a protein:
Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Domain:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence:
MIDVRRKTGPPPPGAAVPGFTAPGIPQPQGQDYSQGIPGQYPQGQGSYNSSIGFGGQPGYQQSGYQQLPAPGGYPQAPAAGGYPQAPAAGGYPQAPSGGGGYQQPAAPSNIYSGGGGDQPPPPAQPAAPKPQEELPEEVPEDPFAGEELPRTPTDDEVPEDPFAGEELPWTPTDDEVPEDPFAGEELPWTPTDDEVPEDPFTGEELPRTPTDDEVPEDPFGGEELPRTPTDDEPPEDPFAGEDLPRTPTDDAPPPQPVPPTHELSQMSLGGWQPGQTRGTVVPTENFDAEEDAKILRKAMKGMGTDEKAILELLAERSNAQRQKIKLQFKTMYGKDLISDLKSELSGDFKESVMALFVPTTEYDAWCLNNAMVGLGTNEEVLIEILCTRTNEEIAEIVRVYRDKFHRDLEKDVVGDTSGHFKRLLVSMTTANRDEVKEVDLEKAKKEAKELYKAGEKKWGTDESEFNRILACRSFPQLKATFDEYIKVSQRDIMGTIDREFSGHVRDGMKAIVMCVRNRPEFFADKIYKCVKGLGTDDHTLIRVIVTRSEYDMVEIKQVFLNKYRKTVWKAIDSDTSGDYKRILQALVKKD
The following text describes a protein:
Function:
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MAYQGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP
The following text describes a protein:
Function:
Regulates neuronal morphology via inhibition of the WAVE regulatory complex (WCR), a complex that controls F-actin cytoskeletal dynamics.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MLKKLWICISCIVTTALSDHITFSPPDEAFVLFHSHQNTNFTSVFVQDGCPNSRNLMATVYSADLSSSRRVFEEIPLHCAVRVRIITEKVVVTRPYVDLLAVVDESLSRHVGAICVHAQLTSSTSAIELGKCYLNRHEDQKSSCVIRIPVPFSWFPVDQNRTSVLSVSYTVSEKCDQNFHDLPQHLIEVNSRIAKQKIDWLANATETSVTLLSTASQAFSQNSMQTLFLHVKSWANETQPMEIRLWVDSRMSIETVYPTSSNWTIRVSSASRPFFYTSLVCTPKERMTGFNDNIVAILIKMVSSTDAIKDDVILHWHVILGPKSSEPPPDDHKVATKFSVIADEVAAVVIVPKRKELMNLAVISGIQVTSSLRIFTISIGAKAEDVTTQSHCISSDANIIKVSPTCSSVYLDGSESNGSSDAQVYAHYLRYTTTYSFRVWFPKLPLKIWMSSSTLSTIKNWKVGFWRDLPLGGGVKRSRAARQFACVNRFQHSHVKVLASLWIEDIKTGDQLYLSSHKSILFDVTNIVHNTLQISNRTVANVKFYEGRAKVIGENVGLAKLIVRNAKKSMDLVSENISVQNKEVSTTGLSARPICDTSFRILPILFSPAFFKVEIAHSKSLTKLYQQCSIFASVSYSDATWEPLNDLDSSYFEMSAHSDNERALAVSHHASKVHVIAIDENWPLPVVEISLQSSAQCASTINGASPAALAVTVLNVPIKINNSFPSATDLDSSFSTTIAPSDSLPSIPFHIFVLTIIGLIILFLFISFVRRSAAFKGYEQLVVPFFSRLSSSSGSNSRQEETNEWVWLSQPQPPSSTISSGYSGNKSTAERQSSNGDDPSRTSISYHGSEISVFIAPSQGNVVVNQSSRHPRYTLVDSNSDHNLARIVPKEDRWTTGGHEQFHTWTWKQRGGGGGRMMEAPIRESIA
The following text describes a protein:
Function:
Acetylates the N-terminal alanine of ribosomal protein uS5. Also plays a role in maturation of the 30S ribosomal subunit. Plays a role in the temperature regulation of pap pilin transcription.
Miscellaneous:
MISCELLANEOUS: Overexpression suppresses the cold-sensitive phenotype associated with the ribosomal protein uS5 G28D mutation (rpsE).
Subcellular Localization:
Cytoplasm.
Sequence:
MFGYRSNVPKVRLTTDRLVVRLVHDRDAWRLADYYAENRHFLKPWEPVRDESHCYPSGWQARLGMINEFHKQGSAFYFGLFDPDEKEIIGVANFSNVVRGSFHACYLGYSIGQKWQGKGLMFEALTAAIRYMQRTQHIHRIMANYMPHNKRSGDLLARLGFEKEGYAKDYLLIDGQWRDHVLTALTTPDWTPGR
The following text describes a protein:
Function:
Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells; Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR. Overproduction is toxic.
Miscellaneous:
MISCELLANEOUS: Binds single-stranded DNA and RNA, but not double-stranded DNA, through hydrophobic interactions without sequence specificity, resulting in a packed structure.
Subcellular Localization:
Cytoplasm.
Sequence:
MEKGTVKWFNNAKGFGFICPEGGGEDIFAHYSTIQMDGYRTLKAGQSVQFDVHQGPKGNHASVIVPVEVEAAVA
The following text describes a protein:
Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MLKLALAPRLLQTPLRGWVVPRAHVSAKPARTPTSPMEQAIGLSVMFLSFLTPAGWVLFHLESYKTGSTK
The following text describes a protein:
Function:
Part of the ABC transporter complex AraFGH involved in L-arabinose import. Responsible for energy coupling to the transport system (Probable).
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein.
Sequence:
MTTQTMTAVSGNDGDTGGDAAESPPGGPLLALDGITVTFPGVRALDAVSLSVRAGEVHGLMGENGAGKSTLLKVLSGVNQPQAGTLTLNGTEQRFASTRAALEAGIAIIYQELHLVPELTVAENLMLGQLPSRLGVVDERTLAARALDALERLGEHIDPGIPVKYLSIGQRQMIEIGKALMRDARVIAFDEPTSSLSARETTQLFRIIRALRAEGRAIIYVTHRMEEVYELCDRVTVFRDGRRIDTFDSVTDLDRDRLIGCMVGRSIEDVYGYRPRAAGDVLIEAKGLAGPGLSEPVSFTARRGEIVGFFGLVGAGRSELMKLLYGAARPSAGHVELNGKRVAFGSPRDAVRAGLALCPEDRKQEGIVAIASVADNLNISARRHFSPARVLLDGRRERELAQRYIERLAIKTRDGDTPIGALSGGNQQKVVLARWLAERIDVFLMDEPTRGIDVGARAEIYNLFYELAEAGRTVILVSSDLAEVIGVSDRIIVMKEGRIAGEVAKAHATPDALIKLALPR
The following text describes a protein:
Function:
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
Miscellaneous:
MISCELLANEOUS: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.
Sequence:
MKKDELTLVKEIRDRFSLPEDIGIGIGDDAAVLNLKSSAILTTDLMIEDVHFELSYTSFYHLGFKIVSVNVSDIYAMGGDFKGFLFSAGVPETVSDQDFKELFDGIEDALKHYGGFLIGGDLSRSKNIVLSGFAVGEAEKPILRKGAQAGDLIFITSYLGLSSAGLNLLNNLSDDEKRFIKSIRNFKNCKEYPDRLLKFKGINEILERHLMPIARKPDKFKHIAKAMMDISDGLLIDLHRLCEENKVGAEIYLDQLPIHPAITKIADYLNIEPMNPILSGGEDYELLVISDRQDAKEFGLIPVGRIVEEKGIYLIDPQRGKIPTKPEGWQHFQ
The following text describes a protein:
Function:
Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde.
Sequence:
MDLTEFIKICRLLYDRKYVVGSGGNVSIRDGNLIYITPTGLSLGFLTKEDICIADLNGNIIKGKPTSELNMHLKIYQNKDSINAVVHTHSMYCTAFSALDKKLKLVTPEAEMVVKKIAYVDYFPCGSLELAENVSECIEDSIILKNHGIVTLGKDITEAYIKTEVLEEVAQLNYIMNNLK
The following text describes a protein:
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
Subcellular Localization:
Secreted.
Sequence:
MGVSGLCICGATLVLLATVVPSHAGLYTPDEPVVHLDRKAHTYLLGSRSFWVAEFYASWCGHCQRFKPSWSGLAEDIKDWRPVVYLGVIDCAESSNFETCNEFGVEGYPTIKSFKSFTKEVSQGVSEDAVHSVQALRENIITRLEEQKDSRPSSWPPLEPISTFEVENFFKTKQENYLALIFEEPSMYIGRETTLDMVQYEGVSVRRVLRDQNDMVNKFWITSYPSLVLLSRNGSNTVVNLKADTRSSYTDFLRSLPGVRKKNLFIIGVANNGTTEQDDRRIADSTKLYMADLESAVHYTLRAEVSRFSHLEGERLDALIAYVSVLRKYFPARPYGTTLLKSIHSWLHDRAGKEVLYKDFENVLNNKDEAQNAVLSSSVNYVWCQGSHPNFRGFPCSLWTLFHFLTVQASEDTAAPPTEVLLGLRGYVKNFFGCRECAGHFESMAAESMNTVNTLDEAILWLWDRHNRVNKRLAGQPSEDPEFPKLPWPSKTLCPFCQVEDGGDELAWDIPNVLNFMKTHYSRQNLANDYLEDEEVLLERQKNGTKKEVTKPNEDISVEETSDKTESHINLRYPQRNAEDHENKNVPLTTQETNPDKNPTESEVQFAAHLRVEDEKNTGEGNSFLLSLLPSRSLQGSIELGSDHALQAKIIIDIPEEEFDHIAVRKRLLRRGIDENFIGVVAEKGTVNVKGRLGKMLEVGFSRLDISLCVLLYFLSSMCLLCMYLYMSLRTRCLRQRTFYP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MLSHAAVKAHTCPQCQQSFLTVHSLKAHIKTHSGKKLFFCGKCEKAFAQKLTLIEHMRLHEDTRAYKCSYCGKGFRQRSTLWGHEKIHKREKVHRCSKCEEHFGTLKELRRHEKKHWVATQQQRVDFAGNPVKESPETRRFECDRCGEAFTQKIVLQTHYRRHTGEKPFECEVCGKKFRHLASNKRHALIHKGTKKYHCDICGRSFTKKSYLKWHIAKPHSNLDHENREKGCSNKESSRATGCLTTVKQNEKIWNEDSDSVLSLESFGGSEIEFDNPMVTSSTGAKDSRSEGEVNSTDDTSKLEDFTLKQGLDSNREQSKLVESLTTPQDPSPQTIEGTGVIVSFQDVCDVPINEECVHTTMNVLDHVMQLAQISQRDVQESPIQIEDIPLGQATPEVDNRNLVKDANEKSPKQSLGIQNSPAVKPFVCELCGRMYSSNSSLLRHKQSHLISKPHNCHFCDKSYSRGPLLREHIQFAHSGEHRAHQCTFCEKSFPNATRLDLHVRIHTQDKPFKCAVCQKGFTDSSNLRRHERSHKGLRTHKCLQCGRLFSEKPALQRHLARHQGEKNYQCQHCTKSFALKADLQSHSILHRAAKESRCSQCGLTFKRQISFSLHQACTKKSARKCRVCSVGLVNECRRRQHELEEHKFLIIDSGFACGHCGKSFNGVGKTVNHIREH
The following text describes a protein:
Function:
May be involved in the control of adherens junction integrity.
Subcellular Localization:
Apical cell membrane. Cell projection, cilium. Cell junction, adherens junction.
Sequence:
MTRTDPPDLLVSTVYQDIKVATPGPASKCSPCERSVARPAEPAPFNKRHCRSFDFLEALDGPAMETLPEPPPPESAVPRARTREAEPRRRARSKSAPRAPPGLTPAPASPPVLPRRGREAQRAARAEASPRREPAYPALRALANELHPIKLQPQRGGPGRVAPLCAAAGRCAPPEPPAGPAPHVRCRLDIKPDDAVLQHATRGSRSCGPTEAAHWARPAPQFHGLTVPGPRHMALSRTPTPSDSYCADPRAFYCDGPLPGPRDYAERRSLPFTTPPGPTQFFYTEEPQGFRGSFAASPGPTFDAYYPRPYPSEELSGPSPRRMGGYYAGEVRTFPIQEPPSRSYYGEAPRAYGLPYGPRYVPEEPRAHSTARPFYTEDFGRYRERDVLARTYPHPRSSPAWADWGPRPYRTLQVVPPSDPDPLLASWHGGTGTSPPRLATDSRHYSRSWDNILAPGPRREDPLGRGRSYENLLGREVREPRGVSPEGRRPPVVVNLSTSPRRYAALSLSETSLTEKGRAGEGLGRNWYVTPEITITDNDLRATERPSARAWELPGGRTRPPPHAAPDGPTSGRQRSLEQLDELITDLVIDSRPTAGQASEPAADCLGPQLRRLLDSRPAGSGAPALAPPRSPPASAGSAEEPAAPGEAADASPEPSADEDDLMTCSNARCRRTETMFNACLYFKSCHSCYTYYCSRLCRREDWDAHKARCVYGRVGSVCRHVLQFCRDSGPVHRAFSRIARVGFLSRGRGVLFLGFPSPGSADNFLRFGLEGLLLSPTYLSLRELATHAAPLGSYARELAAAGRLYEPAECFLLSVSVAVGPGTAPPGTPALPAPAPRSHGPTVRKFAKVALAAGSPARPPPARSREPDMETLILTPPPGTAGLDQDGEAGRRAREVAFIHIQRELRLRGVFLRHEFPRVYEQLCEFVEANRRFTPTTIYPTDRRTGRPFMCMIMAASEPRALDWVASANLLDDIM
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Nucleus. Chromosome, centromere, kinetochore.
Sequence:
MSQLRSSWIPSSQPESHSQMRGTNTIENEAGERSMDQHQTAADEPPSQSDIWMTTLVLAQDMAVVLKEGVEEEVGMMYEALDQTFKWNERRRERVENAHNELLRVNRQVEAKKDALEKMKANSTARENQAEIYSLDQSAYEEARKIKGLDYSIGSVKARTTKLQTELDELEQSEPTRSPDFVIDSSVLKTKLYHDFGFVQVRTPLQEGNNSDPEKLFIRCDSDCTASRVVQKPKTNRDGFTLANEIWDAIS
The following text describes a protein:
Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular Localization:
Nucleus.
Sequence:
MRILTNNPQGKRKSSSKPQGPKRKEKLPTTFQCLFCNHEKSVSVSIEKKSGVGNLQCKVCGQTFQTNINYLSAPVDVYADWIDACDAVAKEAAAGKTATTRATGRMGRVETAREEDEDDVPDADDLRFVEQDDLDAEGEYAE
The following text describes a protein:
Function:
Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. May have a role in the assembly of primary cilia (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin (By similarity).
Sequence:
MISPVVISRLIDEKKSMENGAILPQAIAQPQLCPTKPALARRDGVSMHRRFALSPDRLGILTPSDDQGLETEPLSTGDNLGKGSHSGFSSITITARRVGPPASSLVWDTFRDPLCPKCKAKDALFQEPPVLAGDAHLCQHNRPFTCTESPSNGSVEGMKVFQAHSRLSARQDYWVTHTNDNEDSFSSDNSPSRKVPLVFSSCVHFRVSQQCPNAIYYLDKSLSVPLERPQIASPKMHRSVLSLSLRCSSHQLTADGVDSSANGEPISTALSQELSEGKQDLLGPQWGQPQGGHWKESPALVPVHLGSGTCPRTGSPPLENVKFADVGRNQVPVRKEKEDHATCTSSSHTNQLSIHIPGWSYRAETKVLSGSKKQQQEAQRTLPAFPVGQKTIKHFPPEGDSSPSSDGQPSILSESNERQHPYFMIPRVPLPGFYCPLQTGCASLQEDGAVQIETHFPKDYTCCDLVVKLKECEKNEDPTVTPEPSPATPSPSTPEGAQSSDPSEDSYEPLLASSMTLQEALEVHRPQFISRSQERLQKLKRMVQQRKTQQKESLGQKQSLLPVRANKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYNNLPEVKKKKEEQKKRMILQSNRLRAEVFKKQLLDQLLQRNAV
The following text describes a protein:
Function:
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly nuclear.
Domain:
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Sequence:
MLSCCLRLRVSVPGLALPLPFLLPPSRAPGPRVRRLLLPTFDFSFRQPLLMKPVVVFVLGGPGAGKGTQCTRIVQKYGYTHLSAGDLLRNERNKPDSQYGELIEKYIREGEIVPVEITISLLKREMDKTMEANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFILFFDCDNEICIERCLERGKSSGRSDDNRESLGKRIQTYLQCTKPIIDLYEEMGKVRKVDASKSVEEVFGDVLKIFDKEG
The following text describes a protein:
Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Sequence:
MGIDPPRGIILLCRCQHPLTESGQMTALTTPAGSTAYFRNPAFLLLLHFHFNHTLALTLPFQLSTHQVSRTNLHRSRVPLTTTLVVVVGKIELMLLEGSCKTRILRHMASELNLKMRSDGYVKVQDLLRLNMKTSANIPITSHTFNDIKEAVRLDNKQRFSLLEENGELLVRANQGHTLMLVETKSLLKPILSPEEYPGTRRDANILIYLDIRKAIKGGMKLYISDNKVILTEGFEGVFPVKYFERIESWPDRKLIPF