lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (By similarity). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (By similarity). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody, Midbody ring. Mitochondrion. Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles. May colocalize with CNTRL/centriolin at the midbody ring. However, localization at the midbody at late cytokinesis was not confirmed. Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission.
Sequence:
MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRADQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL
The following text describes a protein:
Function:
Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSMDIRSFFGSPGKPAASSSSTKHTNGKGKRKHDEDDGDFAMFEKKQRHSAKPTKMKKSNIIYDSDSDSDDPKSKKTKTLVKQTESKTSKGPTKLPQPTPEKKKATSAIDFFGNSPVQRSVKKPARKVQPLTNGGAKKPRLEMEEHDDEDFQATLRMMDQDESPPKEDKPAKGKGLASKLAAKVKAGSLVPDTPDREKQKERSRYTEPTIQDTPSGSRQQSRISTKEDEKESPTKRVTRSTPTKPPPAKRAPIKSTTKAKLEITSPPRKKEEAVTSPPGGEGEKRRGSAGYKSYLNREGPRSLGSREEPKGADGCLSGLTFVLTGVIEYFDKDQIKTMVEQHGGRLTTSVSKKTSHLVIGREPGESKVAKAQEFRIKQIQEEELYEMIETRPGKGGSKAKGQAPQQQAKKHEETKPERTISKPDTPSMKPIPSSKDTAIKKEPSSLPSSSSSSSNVSQSGQSSKPAPGRGQSAAGGGQSLMWVDKYKPVSTKNIIGQQGDKSNAKKLLNWLRRWNDNNYGSNKEKAKFNRDAGFAFRAALLSGPPGVGKTTTATLVCQELGFSFIEQNASDSRGKKSLQGGIAESLDNQSIADMFKKGCGKKTSEEGHKHCLIMDEVDGVAGNEDRGGIQELIQMIKTTRTPIICICNDRSHPKIRSLVNYCFDLRFQRPRVPQIKSAMMSIAYKEGLTVPPAALDGMIMAANQDVRQVLHNLSMWSAGQKKMNAEQMNTDARNAKKDLKLGPWDVARQVFSSKDLKTMSFNDKMDLFFHDYSIAGLFVQENYLHVIPDEGRGDIKKQLDLVSKAADSMCQSDLVEKAIRTRNCWRLLPTQAVFASVIPGTTMQGYMGGMINFPSWLGKNSTRGKNFRLLQELQVHMRKSTSASIRSLNQEYLPRLRKFLTQPMVEREADGVPDTVNLMHSYDLLREDFDSLLEVTQYSGFNAPMGKVAPKVKAAFTRLYNKEAHATPYAVDAGGKKKKGKGGGGAAGVEDGLMKVEGEEDEGTQQDEEGSDEDDDVSALRAKPKAAGAKGRGGGSKGKAPAKGKAPVKGKAPAKGKGRGRSK
The following text describes a protein:
Function:
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization (By similarity).
Subcellular Localization:
Cytoplasmic granule. Cytolytic granule. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T-lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation (By similarity).
Sequence:
MRQVPVGTRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPDGIFANCIEEKGPRFDLIAEESNVGPPMTDPVLMRGFPNDFFPISDDYSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSLADMEWEYQPTDENNIVYFNYGPFDRMLTEQNQEQPGDFII
The following text describes a protein:
Function:
Probable tubulin--tyrosine ligase.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSTKKDIKVYVNYRDEYAEPKIISALKNSGKELTFTNSAKEANFQWAQYEDIDFDEVYKNPKTKLCCSYVIRKALIRKEYLWRTVITYLAKHPDSILSKSVPEAYSLELDYAEFLDDSLMEAYELRQELEENATKNISEKQWYILKPSMCDRAQGIRLFSTIEELQAIFDSFDDEESESEEAGLEEKGDITVAFNNKIVISQIRNFLVQKYISKPLLLDHRKFHIRAYVLATGALSVYLFNEMLCLLARDKYKKPTPDPDLLFSHLSNTCLQGDNVEQSSIRDFWNTSIENKDDIFKSILNIIGDVFEAAATTQGIHFQPLENCFEIFGVDFLVDCESQVYLLEVNSYPDFKQTGKNLSNIIENLFSAVVETAIIPFFESSTKRNVDSKLTLAKKLQLFGFR
The following text describes a protein:
Function:
Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
EQDLSNGKSDLLLQMNPVYKKIPVLVHRGKLTNSGVWDIAFAPFCCGFSTYETIGNFSIEAQCPKIIAWANGCLQKESVSKSLAEPGKVHELLSTLFFFCFRLMLENQRREEH
The following text describes a protein:
Function:
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Subcellular Localization:
Cytoplasm.
Domain:
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Sequence:
MAAGKRDYYEVLGISKNASSQDIKRAFRKLAMQYHPDRHKAENETTQKQNEEKFKEVNEAYEVLSDEEKRKLYDQFGHEGLNASGFHEAGFNPFDIFNSVFGEGFSFGMDGDSPFDFIFNRSKKRQQQIVVPYNLDIALVIEINFFEMTNGCNKTIKYERKVSCHSCNGFGAEGGESGLDLCKDCNGNGFVIKNQRSIFGTIQSQVLCSTCNGQGKQIKVKCKTCRSNKYTVTNQIKEINIPAGMYSGEALVDESGGNEFKGHYGKLIIQVNVLASKIFKRSDNNVIANVLVDPMVAIVGGVIELPTLEGIKEFNIRPGTKSGEQIVIPNGGIKFSKSFKRKAGDLIIIISYARPCEYTNLELKKLREFIKPNQEVKQYLNTLKNEYKT
The following text describes a protein:
Function:
Involved in chromosome segregation. During meiotic prophase, connects telomeres to the spindle pole body by forming a bridge between the telomere protein rap1 and the spindle pole body protein sad1.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Chromosome, telomere. Note=Colocalizes with the telomere cluster during the 'horsetail' stage and then disappears before the first meiotic division.
Sequence:
MHLLTTTLISFEQNKVEYLTQIAIYTQTPVCTDSNCEHARFLKHSLIQVSIERIEYLYSIFPNIWQFALLCQGQNKESLIHMEEDASTNFKLRYYVLPWSRRLQGYQSITVQNGSHVPLVKRLEKWRIFVEC
The following text describes a protein:
Function:
Required for accurate chromosome segregation in meiosis. Required for pairing to occur between homologous chromosomes. Acts in early recombination steps and ensures pairing fidelity and proper repair of meiotic DNA double-strand-breaks. Regulates recombination and pairing of homologous chromosomes during meiotic prophase by controlling transport of RAD50 from cytoplasm to the nucleus. May affect pairing of the gene-rich fraction of the genome rather than preventing pairing between repetitive DNA elements.
Subcellular Localization:
Cytoplasm. Note=Localizes to the cytoplasm during leptotene, zygotene and pachytene.
Sequence:
MADAADSSMALVHSSLADSVLTSPRTLRQGQKWEVEYARYFGTPRRDPTAAPPSGLRYIMRGVHRHQGTWIPASCPASLCVCHPSLPSAVPVLTISIGDVVFEEHFVSILNFSWPQVTCVTQCPIRGSRVVFVSFCDKFKQIQKFAVRFPQPCDAESFLSCVECSCGSSGTMDIIPFGSDYVCEDSSASEYIVSNGLHHRLDDASNLEEQCFDHTIDEPPMNYHEETDQHVLEPLSASNTSNNSAFPPSFNQMLKSCSIDYDQEEPCPLAASNHVLQEVYVLDTSHDVANEERTAGKGMDAAEGVDASILTYDLMARIKTYMADESFNDMLLKLDKAIDELGGDMSL
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.
Sequence:
MAENGVAAIKKEFLAEPAQGATGEKRKRKERGQNKRRNKVIVREDNALCPRISLGEECPYGAECRFPHDVEAYLAQKKPDIGKVCTLFDKYGRCPAGFKCRWLSGHVREDEDGNHVLVTRPDAKAPTKVTNSMNKEVQKKLRTKQLDLSKSEEVIALVLGPMNKDDSKQSDRNSERQAAKKEKKKEIEEKGVAASGEEAVTSVSEAVTSGEQKAASSTEQAAPTATEPPTAQPATDTSFEGRAFLELPTLRPQEKKVIDWRNRMVLAPLTTVGNPAFRQLCASFGADTFYSEMALCYPLMQGHQPEWALVRGVESERQTMKTGRRGIFGIQLACGKLWQGVKTAQVLSEYCDGLDFLDLNCGCPIDLVYRQGAGSALLDNHTRLIRSLQGIDTISGSLPTTVKLRMGCRDDHPIAKRLMTRIFHETNVSAVTLHGRSRQQRYSKLADWDYVRQCATEIRTLNEALEEKPDAFPMRNQRMAVIGNGDCFTYKDWYDGMETGVDTVMIARGALVKPWIFEEIEARQSIDKSSTQRLEMLQEFCNHGLSYWGADERGLNTTRRFFLEFMSFFHRYTPVAMYEEGVNPKLNERAPAYKARDDMEAMLASPNVADWISLSERFLGPTPPRFTFTPKHKSNSMDEAEG
The following text describes a protein:
Function:
Involved in the early part of the secretory pathway.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type I membrane protein.
Sequence:
MSALFNFHSFLTVVLLGICACTYLKMHFPAIFEQRTGFRGFFWKAARIGERLSPWVAVGCFTMGVSIIFF
The following text describes a protein:
Function:
Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
Sequence:
MLTFVFTVGDEIVVEPSQVSMNAGDNVTLTCTYKKYVEKEDAEEEEEEDDEEDEDASGSPSLTWLYQDKTIPEDNKRHVFCTSDFLFDVFIIYVSEYDHGLIHVEIYSSREVLLTLSGVERKDAGVYSCVYNGDSAKKPIRFENVVEEHHPLDGLPYVIGCTVVATPKALVSWRFKSLFIKKKSDLGFKKLSSGLEIANVSAVHNGLYECVGHVRKTGEIRSRAILLDVDCQRSQVKRAIVRNISVADVGRYFCVASNKHGSARAVISVKIRVDAAIREIRAEGFIIGHDGVITCESVGFDLPEMTLYKVEESNELSRIPAEVTDLSLTERQLVSRFKSVNMDKDNGTYVCKAGNNWNEVNRTVESDVGMTPVILTLKTEKVYKHPGQPLLLNCTAISRKLCVISWTRKLHREDDDDVIKEDGDSDNDVEKVGDSGDDDKFYRKPIVGNYGVCSRLLVVDEDRIGNYTCHVSNNKGYENVTFVLYIAKKPYDLKSMAIANVTATSVTLELEESYQRGLPVEVIMVTLQPSGGEREVLNYTKLPHDNLKYKITLTNLSDSTPYQVSAQPVNAFHVGPMKFVEFKTKELSRPDPVTIQQIKAACLPPNEVTINWLAPYSSNLPIIKYTLKYRKVLPANSTAPNKWIEKETKDTKYLLSGLEESYKYELLVHAVNKMGRSNDNPAYYFHTCRDDDVVAYGRPLHESSNSKTNYGILLGIIIGVVLLVCLVVDVVCCIFDRCGLTKAIYEATCKKNSKRTKTYNVNERQRLNEEKATTA
The following text describes a protein:
Function:
Major component of the polyhedra envelope.
Subcellular Localization:
Virion membrane. Host cytoplasm. Host nucleus. Note=Found associated with fibrillar structures present in the host nucleus and cytoplasm of infected cells.
Sequence:
MKPTNNVMFDDASVLWIDTDYIYQNLKMPLQAFQQLLFTIPSKHRKMINDAGGSCHNTVKYMVDIYGAAVLVLRTPCSFADQLLSTFIANNYLCYFYRRRRSRSRSRSRSRSRSPHCRPRSRSPHCRPRSRSRSRSRSRSRSSSPRRGRRQIFDALEKIRHQNDMLMSNVNQINLNQTNQFLELSNMMTGVRNQNVQLLAALETAKDVILTRLNTLLAEITDSLPDLTSMLDKLAEQLLDAINTVQQTCATS
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit; With S5 and S12 plays an important role in translational accuracy.
Sequence:
MGGLKKPKKKYLAGKPKKIWNKQLLLEELQLMGEYGLRNKKELWLARARLKWITRRARSLLSMTAEERAPLEMPFKEKLYKMGFIEDPNVQLDRILSLDVRAILERRLQTIVYRMGLAKSIHHARQLIVHGHVAVAGRRVTSPGFLVPRELEDKISLIQ
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein. Note=The C-terminus is located in the intermembrane space, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (By similarity).
Sequence:
MAPGASAPAASRSEDEVGQKIDRCFADSLLKVTGGVAIGIVASVAFFKSRSWPIWFGSGVGLGTGWSNCRHDFASPYVLHGKRVPAGQDSQGKPAYNIITEQHKQ
The following text describes a protein:
Function:
Binds to the G-box motif (5'-CCACGTGG-3') of the rbcS-1A gene promoter. G-box and G-box-like motifs are cis-acting elements defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control. Binds to the G-box motif 5'-CACGTG-3' of LHCB2.4 (At3g27690) promoter. May act as transcriptional activator in light-regulated expression of LHCB2.4. Probably binds DNA as monomer. DNA-binding activity is redox-dependent.
Subcellular Localization:
Nucleus.
Sequence:
MGTSEDKMPFKTTKPTSSAQEVPPTPYPDWQNSMQAYYGGGGTPNPFFPSPVGSPSPHPYMWGAQHHMMPPYGTPVPYPAMYPPGAVYAHPSMPMPPNSGPTNKEPAKDQASGKKSKGNSKKKAEGGDKALSGSGNDGASHSDESVTAGSSDENDENANQQEQGSIRKPSFGQMLADASSQSTTGEIQGSVPMKPVAPGTNLNIGMDLWSSQAGVPVKDERELKRQKRKQSNRESARRSRLRKQAECEQLQQRVESLSNENQSLRDELQRLSSECDKLKSENNSIQDELQRVLGAEAVANLEQNAAGSKDGEGTN
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPRPEHGGPPELYYNERESTKYTNNSRVIDVQFRMSERAMELLSLPSGQPSLILDVGCGSGLSGEIISEMGHFWIGLDISKAMLDVAAWREVNGDLFLQDMGDGIGFRPGTFDGVISISAIQWLCNANKKHHRPAHRLYRFFCSLYIAMARGARAVFQLYPENSEQLELITTAAMKAGFTGGITVDYPNSTRAKKMFLCLFTGQTAAAQLPQGLDTTFSPIANVVQFTNERFEFSGSKNKLAAPAHARKKSRDWILHKKQRRRRQGFEIRADSKYTGRRRKHKF
The following text describes a protein:
Function:
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Subcellular Localization:
Lysosome membrane. Cell projection, lamellipodium. Cell projection, stereocilium. Note=Localization to lysosomes is amino acid-independent (By similarity). Colocalizes with F-actin (By similarity).
Sequence:
MGEAAVAEGPCPLLEDSFTRFSSQSNVYGLAGGADGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAESCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNLPGSSQRLSALGCQSGYVRVAHVDQKNQEILQTWTIQQDGPISRVIVFSLSASEATQDSPQQEGYSLLVASMLEPAVVYWDLLNKGLDDQLLLPGSDQFDSVLCGLVTDVDLDGQLEVLVATYGQELLCYKYRGLPEDSRGFRLLWRRSFASPLLAMAHVDLTGDGLRELAVISLKGVHILQHSLIQASELVLTRLRHQVEQRKHQQGLGDRVGPRPVEHPAS
The following text describes a protein:
Function:
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
Subcellular Localization:
Secreted.
Sequence:
MKSIILFVLSLLLILEKQAAVMGQKDGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDQTRKSQQYDLNALHKVTKSKQHLDGSQQLLNYKQEGRDHDKSEGHFHMIVIHHKGGQAHCGTQNPSQDQGNSPSGKGLSSQYSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQLETKNSHQNKGHYQNVVDVREEHSGKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLNQDQEHGQKAHKISYQSSRTEERQLNHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKMSYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGRKENKISQSSSTEERHLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGRKENKMSYQSSSTEERRLNYGGKSSQKDVSQSSISFQTEKLVEDKSQIQTPNPNQDQWSGQNAKGKSGQSADSEQDLLSHEQKGRYKQESSESRNIVITEHEVAQDDHLTQQYNEDRNPIST
The following text describes a protein:
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular Localization:
Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Sequence:
MMIDYGERNVVPLADIIFYQGEETEMTIHCLCSRAYVNDRELYRSDFKAISSQADSQVQGDVETNDGEQLLEDLNCSVDEDEEEEEEEEDAAVDEETLLMASLGLPVQFASSSKQRRAGQVLARPKNKRTVKCLETSSDYTDANENSEDIAEPPCEQICPTSDEAWLRYWQQHGEGLLWQSWLEKHPENSSSTVQDFSHSQTDWDDHFQQIYKYYWEQFQYWAAQGWTLDESYSTTAASEENQNCQGETEALESETKDRSKADASSVTHLISSLSLLTEEVDMDDGRQPLVCSCADEPCDGGNRKRPSSRAACTDASDGNMKQTSGSAPMNNGSGRPTKSRSNDEDQSDDDDDDEPPGNRRAKVKRAHELDAEEIAEVPVEEAWDALGLRRGSQPKFESVVKLKAGQGSYTGRRREDRKPPEQRRKAACKINKHIFFTDDGPQTTKPKISKALQKVQSFLQQVQTDADSEDVATTSMPEALIGPFDKAELASLPTRKEDEEEASNDTDEEDCETTPQPSRICEEQQHIIPDLEEIHEDEADPRGELQPLDVPDFLLPDAHEDTKKESVQAFKKNKRKKRKRRKDVEMPPEIAAEPELAKYWAQRYRLFSRFDEGIKLDHEGWFSVTPEKIAEHIALRVQDCFNTELIIDAFCGVGGNAIQFALTGKRVIGIDIDPVRLALAQHNAAVYGVEQRIDFLQGDFLQLAPHLRGDMVFLSPPWGGPEYLTADVFNIQTMMTPDGFEIFRLSKMISDNIVYFLPRNADMEQIASLAGPGGKVEVEQNFLNNKLKTITAYFGNLIK
The following text describes a protein:
Function:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Sequence:
MFNFKILIFIYIIFFSPNLMATPKTEKATFAGGCFWCMEGPFESLPGVISVVAGYSGGKEFYPTYQEVSRGKTGHRESVQIEFDSSKIRYEELLTVFWNQIDPTDNGGQFADRGNQYRTGIFYHNQTQKKAAEKSKREISESKKFPGSIVVEIIPFTSFYPAEDYHQNYYKTNSEQYKKYKKYSGREDYLEKMCRQR
The following text describes a protein:
Function:
Catalyzes the reversible, stereospecific retro-aldol cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) to pyruvate and D-glyceraldehyde-3-phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEVTYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLSFVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGIHPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV
The following text describes a protein:
Function:
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Sequence:
MKVNLEWIIKQLQMIVKRAYTPFSNFKVACMIIANNQTFFGVNIENSSFPVTLCAERSAIASMVTSGHRKIDYVFVYFNTKNKSNSPCGMCRQNLLEFSHQKTKLFCIDNDSSYKQFSIDELLMNGFKKS
The following text describes a protein:
Function:
May play a role in primary carbon metabolism and plant growth, by mediating the transport of GABA from the cytosol to mitochondria. When expressed in a heterologous system (yeast), imports Arg and Ala across the plasma membrane and exports Lys and Glu, but does not transport proline.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MGLGGDQSFVPVMDSGQVRLKELGYKQELKRDLSVFSNFAISFSIISVLTGITTTYNTGLRFGGTVTLVYGWFLAGSFTMCVGLSMAEICSSYPTSGGLYYWSAMLAGPRWAPLASWMTGWFNIVGQWAVTASVDFSLAQLIQVIVLLSTGGRNGGGYKGSDFVVIGIHGGILFIHALLNSLPISVLSFIGQLAALWNLLGVLVLMILIPLVSTERATTKFVFTNFNTDNGLGITSYAYIFVLGLLMSQYTITGYDASAHMTEETVDADKNGPRGIISAIGISILFGWGYILGISYAVTDIPSLLSETNNSGGYAIAEIFYLAFKNRFGSGTGGIVCLGVVAVAVFFCGMSSVTSNSRMAYAFSRDGAMPMSPLWHKVNSREVPINAVWLSALISFCMALTSLGSIVAFQAMVSIATIGLYIAYAIPIILRVTLARNTFVPGPFSLGKYGMVVGWVAVLWVVTISVLFSLPVAYPITAETLNYTPVAVAGLVAITLSYWLFSARHWFTGPISNILS
The following text describes a protein:
Function:
Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.
Sequence:
MRGLLLCCFVALASKFESVASYVSLNPKKSYEYRYEGMVNFGLGKQNLAESGVKITCKVKITGASEQTYVLQVSDLAFAEYNGFPGKNGYDASPELTSRIAAQLVKPFMFEYANGHVGDIRASPEVSTTIVNIVRGILDFFQVTVKTTQRVYDLEEVGIHGKCQSYYTIEENMEAKNVTISQVVDVTKCREKAEKYKGMATAVVDKLSKQRGESVYSTVRNVYTIKPTTEGGLLTKAEGRERQHFTPFNVKGGAFKMQATKELVLLGVSDTASTPTFGPMESKGDIIFKFANINYNFPILMQNLEDPIPKITKLIKRLAAANSYQVDSASTEDCMKLYQLMKVVPFEGLTVLWKEFEGNPEQRRWFLDVTVEIGDARTFNFLKSRFQARDLTPTEAWQTYLMAVEHLEATLELVEISKEFLRIPYSKSDINLWHTVVLSYGSVVYKHCAYHTPCPVSTVQPLLDMATEALRDNDKEDMILVLKALGNAGHPGSIKTIMRFLPGVAATPKDLPPAVQSAAVQAMRLIAARDPHSVQDITMSLILQKDLPSEIRMLALVILFDAKPSMAAVSTVTEHLLDEEDLHVASFAYSYLEGFARSTTPDNHFLSTAANVAVKILAPKFGRLSYYYSKAKHMDWFDDDFLIGTATEMYMIRNAAYMFPSEVMMSGKLHVIGRIVKLLDLGMRLEGLKELFGAGIPGFKGDYSFSDFEAILRVLDSWEDLPNNEPLFTAYSRASGQEWFYADVSKDLLRSIITALNPSAWKGSPLWAAIESLKSGASWHYSRAFLIIEASYFLPSTLGLPVEISKYYNSITVMTVNAKAVAKPPPTQHLHQLLNSEIELETDGFAGVTKDFWVFYGVNTELFQSGSEFHNKVPIGLPWKFTTKVNIPEKKFELEFPPCTKEIPLISMRADVYAISRNIAEPDMHKRTPIMPNPTESNAESQKPFWNPNYWHPSYNMCAESDIYGVGMCMEYDLRRQYYHEEFPLYYFLGYSHMELKIVPVNTTKTVEKIYFEVNAGTFKHPINAQLLQSLAQLSKVFQTHLLLILSNVQSSYLYLISAINKHHSNSTPEALFNFKALAMAGNQKHEGYDAAVYYTPEANAHSTQLIVSQVGANTNWKMCVDTSVDARPEAKTHLRWGAECQSYEMSMTAGALHMNSSKPTLMSKVQFVRIPEYMEEMGKRVERYIPGMGLLLGFYQENERNANQEVSASITAVSEDSIDVNIQFPEVSEETCFAVKHAIIHCVPQGCATFSWFPAQHDNTTIDSFG
The following text describes a protein:
Function:
Probable transcription factor involved in the negative regulation of flowering time in both long and short days, probably through the photoperiodic and vernalization pathways. Prevents premature flowering.
Miscellaneous:
MISCELLANEOUS: The early flowering of cv. Nd-1 (especially in short days) is due to a deletion of AGL27. This deletion is associated with the QTL 'FLOWERING 1' (FLW1).
Subcellular Localization:
Nucleus.
Sequence:
MGRRKIEIKRIENKSSRQVTFSKRRNGLIDKARQLSILCESSVAVVVVSASGKLYDSSSGDDISKIIDRYEIQHADELRALDLEEKIQNYLPHKELLETVQSKLEEPNVDNVSVDSLISLEEQLETALSVSRARKAELMMEYIESLKEKEKLLREENQVLASQMGKNTLLATDDERGMFPGSSSGNKIPETLPLLN
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MTQVKVDRMCSVYVIPEDAPMSSQEIAKAFDTGKFDDKLKALKSLVIQIIHDEQMPRMVMNVINSLVPLSDETHSLKKILLFYWEVIEKTHPNGSLKEEMILVCNSLRKDLLHPNEYIRGRTLKLLSRIQLRGILEPLQTAIVENVTHKHVYVRRNAVVCLYEIFLNFGDDLISDLDELMEKLLLNETDLSTKRNAFLLLFHANQQKALDYLNINYSDDSNQFGDILQLSILELFRKVCKKDPLQKPKLLKSIYQFSKSKSASVQYECANTLFAVSPSLASLKIAVQIYMSLINSQTDNNIKLVILDRLEAVNQLNPRVLEDRTQDLSYLLNQQSIDIRRKVLKLFQLKHENVVLLAQSLQKEFQKCQNLNDQSEYKILMLQLINPMIHKFPQVHEVVAQTFIDSIICNNKMDDQCAQLAGQTLVKLVQLSDQPIQHKIVTALSNRFLDIHHMELYKATFTVLGDYSVNPIRSFNQIKKAIGNLPLEHDKAVVKQEDESKQVVKTVILPDGTYGTQVIEKQDTEEHVSKLRELLMQNSFLASSLSRAFMKLLSKIQEFNKYSSQMLLIFCSLLRYYQKNTAKIDQDTLETITSSIRILTGKNPQDKLLEQYKKSEVIPEQNAHFGAHQNYDKILKQPDDPIIIRQLKGVSEFNEIDLADDETSVATKQEENTYVSRLGHIVQLTGYCDPIYAEAFVNVHKYDIQFEVLMVNRWSKMVQNVQVEFRTQGESKVIEKAQGVILQPNQSARVRTTIKFSSQDIGVVYGAIHYENNAGIEQAYLVTKEINVDLIDFIIPATVSIEQFRKFWAKYEWENRIVINTNQNDPFKYVQFLEKQLKVRPIEENHPKGNIICVNMYAQTKFDDDFVLNVSAEVVNDKLQGFVRIRSKVREIVINLGDKIKVLQTKIE