lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Probably acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (By similarity). May also chaperone the processing and/or trafficking of small GTPases independently of GEF activity (By similarity). Involved in the control of polarized cell growth via CDC42-mediated signaling. Involved in the control of cell-wall organization via RHO1-mediated signaling. May also function via RHO2 and RHO4.
Miscellaneous:
MISCELLANEOUS: Present with 6330 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm.
Sequence:
MDYEEILFGLQPILNASSIKDVPMNDVYLGSYLAVMDQLAVSLREPSNRDIVGKTGLLLNLVRVLEQALDICFHDTSISINDKIAFYEISSEVIRCIANAIIDNDDNREILLDSGGKKLLNYYIGGVLQLDEISSDKSEDSLVDKLQMRSVVLLRNFCIGNLKYTENLAPFIRGPLFVLLKTTQYSYLSSPEKVVLGSDLLNDILKVNYSNVQISDLFFLSQYIKKISSNVQNKELQAMEDGAVEAYSNTETQKFAGQGNQEYIEKEEEDDEEDVNCELLLNLSTCLETIVAKDETINFTNEEQLVLSMQKNLILSLVCLESKTFNNKLIVMRRLISCAGNISANLTNSNKREQSLCIETIKSSASSYALAAALMILCNSVASKSDAVALLKLISLSELIQVGSLLQDPLQYQGFLDLLRKLLNLENTMWLDIKDLFTLFQIMRRCHEQTKYYNNLRSLLTNLLNKTLTVLPSSKIHNSISSDPTIISFIAEHGTLTSCIAMDKLLVSKKALPKEAITSLWDSIFKFQNLGQAEQLSISDLFHITKTVGIYLKDSSVTADVNPIENILFKDYIQKLTLILETILSFKENKDKGSESCFNNGKFIAGIILNIVKNTKCLTPEEQNLEALAKSFF
The following text describes a protein:
Function:
Essential for mesoderm formation and axial patterning during embryonic development.
Subcellular Localization:
Secreted.
Sequence:
MHARRLPFLLLHAGWALLQAGAATVAPVPLRTRGEPSSPSPLAYMLSLYRDPLPRADIIRSLQAQDVEVDGQNWTFAFDFSFLSQEEDLVSAELRLQLSSPLDLPLDVPLSIEIFHQPKLEADQDPAYCLERLRMDLFTVTQSQVTFSSGSMVLEVTRPLSKWLKHPGELEEQMSSLAGECWQQPPTPPVADVLLMLYSNLSPEQRRLGGSTLLWEAESSWRAQEGQLSRERDRRHRRHHLPDRSQLCRKVKFQVDFNVIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHRDMIVEECGCL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. uS17m may have a meiosis-specific role as it accumulates during the middle stage of sporulation.
Miscellaneous:
MISCELLANEOUS: Present with 2810 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Sequence:
MARQNFLGLVVSQGKMQKTVKVRVETKVFNKKINKELFHRRDYLVHDEGEISREGDLVRIEATRPLSKRKFFAIAEIIRNKGQQFALYESEAQLSVAKEEAQKAKEFLDKRSVRENKLNEKTTLLRDIRTIQDALSSGSTPKELLEIKQRYGIQDFSQETVRQLLQLDISGLEVNLEKQRSLIDRIQTRLSELLSNDLKCDQFLKDHGVEDPLTLKKNIKKNLLRKHVMMDMQQPSQ
The following text describes a protein:
Function:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Sequence:
MALATFGAGCFWGVEYFFRQVNGVTNATCGYMGGNNEVTTYEEVKKGKTGHAEVVQVEFDPTIVSYDELLEVFWKNHNPTTLNMQGGDIGTQYRSTIFFHDREQKAAAEASKLAFARSGRWGLRHIVTEIVPLQQFHVAEEYHQNYIDKNNLPSCHLEY
The following text describes a protein:
Function:
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
Sequence:
MAVAVQQPDTGRYLAQWRDRLDRGVGFDNWGQMIEACDEYDKVVSEIKSTVHKQKPPFTEDVCKFLVNVAIAATLRAKAAQDLTGKVAGVTLSEMRHLIETMKQLPDTVPPFPLPGVEEFRHLMPAPAPHMGSLAGAGAQGDQDTDNEDDQDADHATTGGSLKPRINFPGKTNITIFIQKIQLKDPSQYIEPYFTISVKDATGKDLAAPQDTPPTNRKDNDFIHFTQPIEIQLALEDLSADCAIFLEFKHFKPRKHKTSVKCFSLMELDELIHSAQAVPLEIYAKPTDFKRRKLHLLTEKKHYLWVMVHLTKN
The following text describes a protein:
Function:
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane. Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases. Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency. Transports T4 and E1S in a pH-insensitive manner. Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity).
Sequence:
MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLGALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLIMGVGTLLIAMPQFFMEQYKYEIYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIRDDHTDYQTPQGENVKIMEMARDFLPSLKYLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIAMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNPRCKCSETKWEPMCGENGITYVSACPAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLSIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSIFLSIAVLFILKKNYVSKHRNFITKRERTMVSTRFQKENCTTSDHLLQPKYWPGKETQL
The following text describes a protein:
Function:
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MSVFMDLNIINSSDKNRLKHIIETAAHLGYSTVAINYVVEPLQKKQEIPNPQSISDLFDKFPVVQGKSSPIKVLNRLTIVASDASHFRPTNEYKKFDLVAVYPKTEKLFHAACMTFDVDIICIAVTEKQPFHFKRAPVNGAIDRGIFFETCYAAAIRDSITRRYTIANAICLMEICKGKNVIVSSGAERQLELRGPYDIANLGLVFSLSEGDAKAAVSTNCRSVLLHGETRATASGVIHTMKKPQILQKEEEETPAAKKARTELA
The following text describes a protein:
Function:
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSTVSSALELPQRLALHPRESPRSPEEEDPHLLSSLAAVQTLANVIRPCYGPHGRQKFLVTMKGETVCTGCAAAILRALELEHPAAWLLREAAQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAIQSLGPLEDPSWALHSVMNTHTLSSTDHLTKLVAHACWAIKELDGSFKPERVGVCALHGGTLEDSCLLPGLAMSGKVCGQMAAVLNGARVALFACPFGPAHPNAPATARLSSPADLAQFSKGSDQLLEKQVGQLAATGINVAVVLGEVDEETLMLADRYGIVVIQARSRMEIIYLSEVLDTPLLPRLLPPQRPGRCQRVYRQELGDGLVVVFEWECTGTPALTVVLRGATTQGLRSAEQAIYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGLAFLAFARALKYLPKTLAENAGLAVSDVVAEMSGVHQGGNLLMGVGAEGIINVAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDKIVMAKKSPTHQQIWNPDSKKTKKRPPPVENKKILGMNK
The following text describes a protein:
Function:
Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (FRD1), essential for anaerobic growth. Involved in maintaining redox balance during oxygen deficiency conditions. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2).
Miscellaneous:
MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MIRSVRRVFIYVSIFVLIIVLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY
The following text describes a protein:
Function:
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Is involved in resistance to the arginine analog canavanine (CAN).
Sequence:
MVKKAKRKARAAAKEKQNPVASPNPIDQQHTQKVNAPEDGVIAVNEKKICPHIDKGIDVEKVSTKLRSSGPVKCEDCREGAVNRRAGKGKGKHGKKKGGGESTSASKAIWVCLECAHFSCGGVGFPTTPQSHAVRHARQYHHHLVVQFENPQLRWCFPCDRLIPAEKVEDGTEHKDVLQDIIKIIKGRPSEGPSVDVEDVWFGKGSSTSGINSAASLDIGAYRKGGYIVRGLFNLGNTCFFNSIIQNLLALNRLRDYFLELDECDGPFAAAFRKLFAETSIGDASRNAINPKSFFVSLCAKAPQFRGYQQHDSHELLHCLLDGLSTEELTARKKLKTSQDDGKSPTYVDAIFGGRLSSTVTCLECGHSSLVYEPFLDLSLPVPTKKTPSKKAQPVSRPKKLKHAPKKSGRGRPKISRDAASPNLQSAQDSGSKSFCQVQPSGPITEGTEVPSDCALQDSLDASYVADNMGLSSHNFDSSLKSSNEKNVNRVTGELTSEDNFTWLDYLDQDILPNDNDMASQITSHDLYSSQKSNNEQNDDVVTGRSTSMDYITCSEYLDQDIMPKSDDVASQNDIRSNQGCATENVVQPNNVALQNDLIAPSDSKLTCGEEACSPGNLMCLDDQGRSKSADCNIASQLGKDRDAREVEHNSASSSQFRSVDSNLDSSLRLEEVEAPLQVKDSEILLLPYKEETSTTSEVLKGEDVVYPDAAGCEQDTLDFDGFGGLFNEPEPVAGPAEKPLPNGYGEASSVVGNSTESDPDEIDNTDAPVSVESCLACFTKPELLSKTEHAWQCENCAKLLREERMRLKNKLPKPGSGDLGNAPGDSDPRDIDVRATNGSVGKGLSDAFDDRLVYQNGTNGNLNCTPETSHRSDQDLVPRPSEDGVHSSQDEACSLVNCDNQNNGVQLDERAANYESGESEIETDSKGVKVERDATKRILIDKTPPILTIHLKRFSQDSRGRLSKLSGHVNFRDTIDITTFVDPRCLKKEVYKYRLVGVVEHSGTMRGGHYVAYVRGGPKIAGKDKDAEDYVWYYSSDAYVREVSLEEVLRSEAYILFYEEI
The following text describes a protein:
Function:
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Subcellular Localization:
Endoplasmic reticulum lumen.
Sequence:
MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL
The following text describes a protein:
Function:
Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDKTEITFTDKIVIDKQEALMRFESLLYQIKPYLWQRWCAFGFMMFLFLLRVFTWHAYYYIVYIIGLYLLSCVVEFISPKRDPELYGEEVLPSAKDGDYKPFVRRLPEFQFWCCCMPASVLACFFSLMPFDLPVYAPLLFVYFIVVSVFVFRKRIMHMIKYKYVPWDTGKQKYQRPTE
The following text describes a protein:
Function:
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity).
Subcellular Localization:
Nucleus, nucleolus. Nucleus, nucleoplasm.
Sequence:
MIRRVRVTVRVSRACRPHHVRIFVAKIVQALCRASASINQGTPFQVLLIVRKKRHRGRSGHDDGQCTPGSNPVAVRGGTQHPRPDNPHPASPRRCPGGLPGHSDAAPSGRGAAGCQGLLGSPACGPRRGTRTPPRGRIPARGGEGRLNDTVQEAQ
The following text describes a protein:
Function:
Together with YIP4B, involved in the regulation of cell elongation during root and hypocotyl growth. YIP4A and YIP4B are central trafficking components in Rho-of-plant (ROPs, e.g. ARAC4/ROP2, ARAC5/ROP4 and ARAC3/ROP6) small GTPases-dependent root hair formation, thus contributing to activation and plasma membrane accumulation of ROPs during hair initiation. The ECH/YIP4 complex is involved in the modulation of the trans-Golgi network (TGN)-mediated trafficking of some proteins and cell wall components (e.g. pectin and hemicellulose) to the cell wall in dark-grown hypocotyls and in secretory cells of the seed coat.
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Sequence:
MSQGDTVPLHPSSQSDIDEIENLINESVQSGPGTVLAARPPSPTRPSIPVSSSSSSSPFMQSNLPPLHPSSSAQKVTHVPVPPPLPAVSNSSNFQGASAFGSPPNTLTEPVWDTVKRDLSRIVSNLKLVVFPNPYREDPGKALRDWDLWGPFFFIVFLGLTLSWSASVKKSEVFAVAFALLAAGAVILTLNVLLLGGHIIFFQSLSLLGYCLFPLDVGAVICMLKDNVILKMVVVSVTLAWSSWAAYPFMSSAVNPRRKALALYPVFLMYVSVGFLIIAIN
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MNSSLTAQRRGSDAELGPWVMAARSKDAAPSQRDGLLPVKVEEDSPGSWEPNYPAASPDPETSRLHFRQLRYQEVAGPEEALSRLRELCRRWLRPELLSKEQILELLVLEQFLTILPEELQAWVREHCPESGEEAVAVVRALQRALDGTSSQGMVTFEDTAVSLTWEEWERLDPARRDFCRESAQKDSGSTVPPSLESRVENKELIPMQQILEEAEPQGQLQEAFQGKRPLFSKCGSTHEDRVEKQSGDPLPLKLENSPEAEGLNSISDVNKNGSIEGEDSKNNELQNSARCSNLVLCQHIPKAERPTDSEEHGNKCKQSFHMVTWHVLKPHKSDSGDSFHHSSLFETQRQLHEERPYKCGNCGKSFKQRSDLFRHQRIHTGEKPYGCQECGKSFSQSAALTKHQRTHTGEKPYTCLKCGERFRQNSHLNRHQSTHSRDKHFKCEECGETCHISNLFRHQRLHKGERPYKCEECEKSFKQRSDLFKHHRIHTGEKPYGCSVCGKRFNQSATLIKHQRIHTGEKPYKCLECGERFRQSTHLIRHQRIHQNKVLSAGRGGSRL
The following text describes a protein:
Function:
Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis. Also plays a role in the regulation of the endocytic trafficking of EGFR.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Lipid droplet. Note=Trafficking through the Golgi is necessary for ER membrane localization.
Sequence:
MEQAAGEPTRTCLTEDIPKAKRCTVIGGCGFLGQHMVEQLLARGYAVNVFDIRQGFDNPRVQFFLGDLCSQQDLYPALKGVSTVFHCASPPPFNNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYATKPIDYYTETKILQERAVLGAHDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAAKKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSQDTALGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWLAYYLALLVSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCEKAKKLMGYRPLVTMDDAVDKTVRSFHHLRKVM
The following text describes a protein:
Function:
Key component of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. RqcH recruits Ala-charged tRNA, and with RqcP directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal alanine extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
Sequence:
MAYDGLFTKKMVESLQFLTTGRVHKINQPDNDTILMVVRQNRQNHQLLLSIHPNFSRLQLTTKKYDNPFNPPMFARVFRKHLEGGIIESIKQIGNDRRIEIDIKSKDEIGDTIYRTVILEIMGKHSNLILVDENRKIIEGFKHLTPNTNHYRTVMPGFNYEAPPTQHKINPYDITGAEVLKYIDFNAGNIAKQLLNQFEGFSPLITNEIVSRRQFMTSSTLPEAFDEVMAETKLPPTPIFHKNHETGKEDFYFIKLNQFNDDTVTYDSLNDLLDRFYDARGERERVKQRANDLVRFVQQQLHKYQNKLAKLIEEYEQSKNKDTEQLYGELITANIYRIKQGDKEVTALNYYTNEEVVIPLNPTKSPSANAQYYYKQYNRMKTRERELQHQIQLTKDNIDYFSTIEQQLHHISVHDIDEIRDELAEQGFMKQRKNQTKKKKAQIQLQHYVSTDGDDIYVGKNNKQNDYLTNKKAKKTHTWLHTKDIPGSHVVIFNDAPSDTTIKEAAMLAGYFSKAGNSGQIPVDYTLIKNVHKPSGAKPGFVTYDNQKTLYATPDYELIQKMKQS
The following text describes a protein:
Function:
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
Subcellular Localization:
Cytoplasm.
Sequence:
MSRAALLVLADGRFPAGGHAHSGGAEAAVRAGRITDAASLEAFCRGRLHTSGVVAACVAAASALGADPGELDRAADARTPSPALRVAARRLGRQLTRAARATWPSPELDALASLFPKGAHQPVVLGLAARAAGLGALDAAYCSLYEGVSGPATAVVRLLGLDPFDATGVLARLAGELDRIAVDAVEVAERVPTDGVGVLPARSAPLLEIGAEAHAAWPVRLFAS
The following text describes a protein:
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.
Sequence:
MDSNYNYVHMNKPGVVLFASDWLKDRLPVDDVEVRVEHLPPVTEDEMTIQHSSANLILMKNKQLRHEPAWKDLELEDLVNAFAFIQGSSNAEGKNTIEDNFETDPFKSVKEAPMAPFLEANRRHQGEHASMRYFR
The following text describes a protein:
Function:
Required for the maturation and activation of urease via the functional incorporation of the urease nickel metallocenter.
Sequence:
MASHDHHHHHHHHHSHGEGDGQAAGGSWVGEDGRVWHSHDGLAPHSHEPIYSPGDFTKRAPPLASRTFTERAFTVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLIKHGALPEERIRAVETGGCPHAAIREDISINLGPLEELSSLCKADLLLCESGGDNLAANFSRELADYIIYIIDVSGGDKIPRKGGPGITQADLLVINKTDLAPAVGADLAVMERDALRMREGGPFVFAQVKHGVGVEEIVNHVLQAWEIATGNKRR
The following text describes a protein:
Function:
Represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. Also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers.
Sequence:
MEEEPYKRKLTKAEKKAKYRTDYAEPLKSRREVLKAIMNGPESERERKVRAKNREFFNEDYRSGVNIYGMAVDMMKAMPDRGKTSGQSLAVWYLEDFGVWLKESGQETELRQKYLTGTIQINALDVCTIGQKQLLSEIFDITKEKFTEDITQLLDAAIKKQDFSVAADMAIQYNLLRDHHFEHLVLPLMLSGKDQTAYKLISNNERMQQQLVEFFDRMVGISVVAVEEMLKPYKETKIMTIPMEKLTGKTLDKLISTIINKNTHEYNFSRELSKFAKNHSQNGNLKALKFNISERYEKGKSDDNYFQHMVETFTKAEDVREPILFYLWSSNDTEKQIDAICFAIYLGIASSSSYQLPNVMRDFFRQPDSKLREAKELLVRRKTLQVPLNGEQLFVFENERRTQIHMVKTESEMNYLCSEIKSLSDEPAPVYVGFDSEWKPSNLTAVHDSKIAIIQLFFKNCVWLVDCVELEKANMADDWWQKFASRLFGDSPVKVVGFDMRNDLDAMATIPALKSSMKIEDTKNAFDLKRLAENVCDIDMEILELPKKTFKLADLTHYLLGLELDKTEQCSNWQCRPLRKKQIVYAALDAVVVVETFKKILSIVEEKNKDADIEKIVRESNVMAPKKDKGHKSYRKLKTIPWLELYDILRSHRNPTRSPQRPHDIKVIVDTMLIGFGKNLRRVGIDVILPKDVSDFRKYLKEIERVGGEHLRHIITVPSKSYEALKMDYDNYTIAIPELNNMSPVDQLIEFFDLFNVDIRPEDVYPRCTECNSRLQIKFPGPVLHFLHQYCVIHVQNVYRADMSEFPLEEWWNRMLHINPDDYDGVKVEMSRPSPTSKWIVATVPTGCLHITRQTALHTNLPDGIEVRIHKVPDDEFKRRNLSFYVCGECGTVACDGRGNQASESTSQEC
The following text describes a protein:
Function:
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This may be a 5' to 3' ssDNA exonuclease (By similarity).
Sequence:
MRPVSMLKEYAYCPRVAYYMEVLRPSYRPTEPMNLSREIYSVDHVRGILRSSGFRIVKEEWAVPLRSKRLGLQGVADGVVVEGSLGIIVVEAKLSVRSNRWLHTRGRHVIFQAAAYALALEETRGYSVDYLAIVSLEDSKTYVVKMSPSLRRDVIRLADDMNKTLDDGLEPPPKPGRKCVACRFRRVCQPWVAERGSER
The following text describes a protein:
Function:
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Sequence:
MIGQFDGHVPGAASDTSAPECAPERDGPLATRVNNGATPSVGIPRPGLAQQLHESLNNPNALPGYSVGPVIGEGGFCKVRLGTHLVSGEKVAIKVIDKTRLTDPTDRKRVAREIKVLKKLNQQSNIIRLLEVGEASSRIHVIMEHASGGTLLDHVRKKKRLPEPEARDCLRQILVGLTYCHAQGVIHRDIKLENLLLTADRQMKIIDFGLSAILVPGKKLRVHCGSPSYAAPEIVSRQLYDGPPVDVWSLGVVLFAMITGYLPFHASGSNKDELCQKIIAGVYKTPDWISDESKDLLRGMLTTDPRRRLTLEQVADHPWVRGKSVPCWRLPGLPTELECRPPLDPAILNCISKRIDTQSLSESILRGEHTYFTATYHLLATRAQSDRRRAYGEPDRPPLVAS
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MAGPQDASLEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDATSNNASLAIQANYNEAFRHFVETREAFEGRLRTMQGLEFVVAYDPLQAAAQTDTQFAHEPSNVWVIRKQMRRKRAGQEDEVVVLATFFVVGDCIYMAPSVASVVGNRILSAVTSLTSLLKTASTLPIFTPAHGHTYLPPAPKPADAGQPGVPSQQSKENTPMPDAENPARVPLVGSQAGNTASTFQDTRTLAESLHLFLRYEDEYMDENPLVGEPGSFIMSKANDVDRTATAKQPQSTIPTKMGAPLVRVDTPGKGPEKVGTPSSSDESSLKKKKGGVGG
The following text describes a protein:
Function:
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular Localization:
Cytoplasm.
Sequence:
MSLSNNEFLAKLTELFTPDPQRPRTCFLTQKRFAYQADGDAIMETPGKEPTFKCLFRATDGHAIKFSTLVEPDQTLVFHKAYSNVMRTRMIAKLKPKKKKAGKPAAVSAVRLPKIVGPKRGPGVERRRRLVAQRSKILMKIRRRKLLKVAATTTTT
The following text describes a protein:
Function:
Required for the final endonucleolytic cleavage of 20S pre-rRNA at site D in the cytoplasm, converting it into the mature 18S rRNA. Involved in normal export of the pre-40S particles from the nucleus to the cytoplasm. No longer associates with pre-40S subunits in RPS19 disruptions, suggesting it acts after the ribosomal protein in 18S rRNA maturation.
Miscellaneous:
MISCELLANEOUS: Present with 10300 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Sequence:
MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSNDEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLGNYILE
The following text describes a protein:
Function:
Hydrolyzes a wide variety of P-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, gentiobiose-6P, methyl-beta-glucoside-6P and p-nitrophenyl-beta-D-glucopyranoside-6P. Is also able to hydrolyze phospho-N,N'-diacetylchitobiose.
Sequence:
MSQKLKVVTIGGGSSYTPELLEGFIKRYHELPVSELWLVDVEGGKPKLDIIFDLCQRMIDNAGVPMKLYKTLDRREALKDADFVTTQLRVGQLPARELDERIPLSHGYLGQETNGAGGLFKGLRTIPVIFDIVKDVEELCPNAWVINFTNPAGMVTEAVYRHTGFKRFIGVCNIPIGMKMFIRDVLMLKDSDDLSIDLFGLNHMVFIKDVLINGKSRFAELLDGVASGQLKASSVKNIFDLPFSEGLIRSLNLLPCSYLLYYFKQKEMLAIEMGEYYKGGARAQVVQKVEKQLFELYKNPELKVKPKELEQRGGAYYSDAACEVINAIYNDKQAEHYVNIPHHGQIDNIPADWAVEMTCKLGRDGATPHPRITHFDDKVMGLIHTIKGFEIAASNAALSGEFNDVLLALNLSPLVHSDRDAELLAREMILAHEKWLPNFADCIAELKKAH