lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Miscellaneous:
MISCELLANEOUS: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Sequence:
MSMMLSNWALSPRYVGQRNLIHCTTLFHTLTRWAKDADDKYHDINSMYENMFTPSNDNVSILQDEGKSDYDTTKASSMEEDISAFNKDLYNFYNIGYAKQIMSASQLENIVKAKGRFVIQSLSTSPYYNLALENYVFKNTPRAKRGPDNCRLLFYINDRCAVIGKNQNLWQEVDLAKLKSKNFELLRRFSGGGTVLHDLGNVNYSYLTSREKFETKFFNKMIIKWLNSLNPELRLDLNERGDIIQDGFKISGSAYKIAGGKAYHHATMLLNADLEQFSGLLEPSLPNNMEWESSGVHSVKSKIKNVGIITPNQFIAVVSERFQKTFKVDGEIPIYYCDEFKSINDEIKDAMNTLQSEQWKYFSGPKFSVKIKDKGLTIKVEKGMIYDCDRNDLIGLEFKGFLENIDSYT
The following text describes a protein:
Function:
Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system or the alternative ribosome-rescue factor A (arfA).
Subcellular Localization:
Cytoplasm.
Domain:
The unstructured C-terminal region is required for ribosome binding and peptidyl-tRNA hydrolase activity. The C-terminal tail functions as a sensor to discriminate between stalled and actively translating ribosomes by binding in the mRNA entry channel downstream of the A site between the head and shoulder of the 30S subunit. This allows the N-terminal globular domain to sample different conformations, so that its conserved GGQ motif is optimally positioned in the peptidyltransferase center (PTC) to catalyze the hydrolysis of peptidyl-tRNA. The N-terminal domain of ArfB is bound in the A site of the 50S subunit next to the P-site tRNA.
Sequence:
MIVISRHVAIPDGELEITAIRAQGAGGQHVNKTSTAIHLRFDIRASSLPEYYKERLLAASHHLISSDGVIVIKAQEYRSQELNREAALARLVAMIKELTTEKKARRPTRPTRASKERRLASKAQKSSVKAMRGKVRSGRE
The following text describes a protein:
Function:
Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD proteins.
Subcellular Localization:
Nucleus outer membrane; Single-pass membrane protein.
Sequence:
MGDSELDYTIEFPEPSLQGWPWDPEREPVVILLGWGGCKDHYLAKYSAIYHNQGCTVIKYTAAWKAVFITESLGLNSLREDAKKLLELLFDYEIEKSPIVFHVFSNGGFMLYRYIVELLHSHCPLNKLHVVGTIFDSAPGNRNVIGSVRALDTILRTSTNKAFRFLALAAFAILVIILRILLYPLTRFLHENHYDAMKKDPSRWPQLYLYSRADPIISYLDVESMIAARRRRCLPTETLDFGKSEHVSHFRRFPQRYSEICTSFLRDCVRKASISMLRSEHPVSF
The following text describes a protein:
Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Sequence:
MSPDAIRVVVCGDDAVGKSSLITSLIKETIIEPQTNNVLPPITISRNDYIESSQEYLNDQDHHHHHQSSPSTMKNKRKHNNKRERERERESSINNVQPNEISEYIPNITTIIDTSSSDMTNLQKELKRADVIWLVYSDHYTYERISLHWMPLFRSMGVNLPIILCANKSDLFPKSKSNLKSTNSDEFVPLINEFKEIEAGVRCSAKNNYNVVEAFYLCQRAVTHPISPIFDAKEGNLKPGAIKPLKRIFWLSDTDQDGYLNFEELSELHKKCFGIEASKSDYEEIVNLIDQKILPSYNTTIETQTPPQQQHLATSAGTPNGTTTTTSKGISEDGFILLNKIYAESGRHETVWCILRAYHYTNSLSLSDKFLYPRLDVNPHSSVELSPTGYKFFVDLFIKFDKDNDGGLNEDELNTLFRSTPGIPKLWVESNFPSSIVCNEEGYVTLQGWLAQWNLTTFLSYKTTLEYLAYLGFDEGNSTKALKVTKPRKIRQKNGKTYRNAVNDRNVFNCFIVGAPKAGKSSLLESFLHGSYSDIYSPTIQPRLVVKDIELRGGKQCYLILEELGELEPAILENKSRLDQCDVICYAYDSSDPESFQYLVELREKHGHLLDEVPAVFVALKADLDKQQQRCDVQPENYTRDLFLNSPLHVSLAWNSSLHEMFIQLVDAAKTPSSATPGIELEVSVDQDDIKHIIMTGAAIAVVGLVSIWVLNSLRR
The following text describes a protein:
Function:
May function as sodium-coupled metabolite transporter across the chloroplast envelope; May operate as a cation/H(+) antiporter.
Subcellular Localization:
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Sequence:
MEKVDCYVVPQTTGTSRNIFQGGSPLSSSLPLLGVQLVLIVVVTRVLYLLCRPLKQPRVVTDIMAGVILGPSLLCRYEWFKQLVFPARGEPVLNTVATFGLMYVIFLIGVRMDPMQALRSGKKGVTIGLSGFLIALGLTASGFSGDALSKEEDHMSTRLTFQFALAATLSLTSFAVLSPILSELNLLNSDLGRIAMSASMTTDGIAWLIMVGYVLAEAYLVSPATSLWAFTSVAALVAFILLVVRPIALLVIERTPSGSPVDEAYVFFFLLIVLLVGLYSDIIGTNSFHGALMLGLAIPDGPPLGTALGEKIEAMVTGLILPLYYTMTGLSTDMWEIHWGRLQLILLLGWFGKLAGVLASSLCLDIPPLDAVSLSLFMNSKGIVEVITFSFFVTNKLIDKHMFSDLVFSSVMITAVSVPVASCLYDPARRYAVYKRRTVQHLKADADLRILACIHDESHVQGTLSLLEASHATPQTPVALCLLQLVEIAGRSAPVFIPHKLRRSASSRIGPTSSASAQSTDSDRIINAFLQYEQRHPEGAVSMQSFTTISPYSSMHDEVCRLAVDKRTSLILLHYHKRHMLAGGMRAAMGLRVVNRKVLEVAPCSVGVFVDRNAGSVGLSAFIMQDHPASSSSGGRLGFHAAVAALFFGGGDDREALAYVTRMARHPGSRAAVIRFLPTRGIKDDPADRRVDNKAIEEVKALAARSKYMNLQVQEELVGDMEKIVEVLRGLDKAGYDLVIVGMRHRWYPVMSANGLSDWSECPELGVIGDLLASSDFDTPYSVLIMKQQDQGGLNAAVPGAQDVWHGDDGAAAPTPERVMTTAVSSRYRQ
The following text describes a protein:
Function:
Zinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechanism remains to be elucidated.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Golgi apparatus.
Sequence:
MLQGHSSVFQALLGTFFTWGMTAAGAALVFVFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGSTLMKKKSDPEGPALLFPESELSIRIGRAGLLSDKSENGEAYQRKKAAATGLPEGPAVPVPSRGNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASWASILGFVVMMSLDVGLG
The following text describes a protein:
Function:
Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity in vitro. Overexpression leads to growth arrest after 30 minutes; these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the both TA proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression.
Sequence:
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKNKDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
The following text describes a protein:
Function:
Probable transcription factor required for chromosome organization and progression during male meiosis (e.g. microsporogenesis). Necessary for fertility and meiotic progressive compaction of prophase I chromosomes to metaphase I bivalents. Together with JMJ16, promotes gene expression in male meiocytes in an H3K9me3-dependent manner, and contributes to meiotic chromosome condensation by triggering some condensin promoters (e.g. CAP-D3 and CAP-H).
Subcellular Localization:
Nucleus.
Sequence:
MPVPIIETCRKRKRKPKVYNLQRFGEDGFPIQRNGAFRDQIRVFLRDCAEIEDYDIRGMTVWCTLLSHETKSSLIPLYIVEENVKHSSEPYCDHCRCTGWSNHFVSKRKYHFIIPIDTEWSLPLEDDAFDSQSHVLHGLIHCNGFGHLVCVNGMESGSKYLCGREIVDFWDRLCNSLGARMITVEDLAKKRSVELRLLYGVAYGHSWFGRWGYKFCCGSFGVTKNEYENAIEALGSLEIDQIEFDFGELRQSKEINQVFRYYREMSEGHLKTFRDLLRFMLIIKSHASPQKLLPVTPPLLTDSPHQKRSSRLLLKKSDVADNDKSPKYRNYSTVAANLGSRWPVRRLIFAAEVIVESLKEMKALKQNGMTRQDVRDSARLHIGDTGLLDYVLKSMNNVVVGDVLVRRYVDPITRILHYTIQDLDDAVKAKEPKKKEAVVLEEITPLRILTPLKPGADVYGDLLLLYTNVLLNYPESELVRSATQAILDSKHFIKEWPIWDNNDTVLQFLCRINPSLVDVRSEQTTELPPGELVTVPLQATVYDLKQAIEETFRDTYCILSNFVVTEIDEVEEDMSLIGSCSALTVRGHGIDLESKLKCQGGCDTWMVKCICRARDDDGERMISCDVCEVWQHTRCCGIDDSDTLPPLFVCSNCCEEFAEQQRKVLQPKYEFPSSENVFLLESADDFFGDQRCLGMIFPEENYLL
The following text describes a protein:
Function:
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEKYYRTFDANRADLVNLFREESVLDFEGQQIKGKEAILAKLTSILECRHDITDFNCLRHRTPGSMLVWVCGQTWVGGRRRYKPDVPSDANTRRRLLRRNTNLEAL
The following text describes a protein:
Function:
Required for efficient mating.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MVAISMIWFFTKRMPRIFALAFNLISIFLLIFLLIGCYNPSNQSTFLVKYKFDDNSPFYTIIEKSYEKSNTTLGLEEVIIRSGYMGVCIDNIPSQYSSYNNMTTFSNSICYARKNLSSVPLYRDLEIQLSNIASSSSKTQSSVVLNILKLAQLTSVNVIHPYVLMATVILTILMFLFILYVTVPKLPFKLAVNKFLLLLSSTIVLTWGIGAMWTHVGINASYRLVPSSSMNIITVKKGKKAAVMAWFSFAFLLLDSVVLWLIFLRDRKSLKDEIDNVPCAQNRYNNYSSDSSTLHSKV
The following text describes a protein:
Function:
Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation. Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals. Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1.
Subcellular Localization:
Nucleus inner membrane; Multi-pass membrane protein.
Sequence:
MARPQNHRRSNWTERDDNDDYLFQRFLEESETRHSREPSPVTEQSQQELQQDVQQAIDGIFNSLRRNMSSTSNINRAANMDATTNGNGGINADTIRATNANTADSPFTARQQSPLRTFLRNLFILDYFIGLILFPFSVYNILRSGFNSMTFSENDFIIEIVGYWKFAKIFGSGGTTLIAYKDTGKLGLLGKFHNIIVFYSSPVIKHIMKSRDGNEPNLNWIRLMFAKAFELFVKVSTILIYLAYGVSGTVYMVTAGFFFVLCLLFTVIRRYKGVHRMLVSQRITGPGVF
The following text describes a protein:
Function:
Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation. Essential for testicular stem-cell differentiation and sustained spermatogenesis.
Subcellular Localization:
Nucleus, nucleoplasm.
Sequence:
MSAGGDGGPRSAGSSPVPSPASPGGEEPSQKRQRTVEDFNQFCTFVLAYAGYIPYPDENEPWSHGGSMSPQNSTGSTQDSDSWASSHSSDLHLLADDRSSRSAARGAADSSLLLGCPAFPTGFYDVRPQQTKRKKPPVKKLILEQEVEKLSAGKGFGLEQERGTELAALEGRVPPGKEELLEPPLNLAGDPQPRALLEELMKEEKDWVHGAQGAGKPAGDEPQLKEQEQCSGGRKSPGSCSTLDQSEGEDASRGSSQLSDEFAAAPNTKAEDDDAWDLITCFCLKPFAGRPMIECNECATWIHLSCAKIRKSNVPEIFICQRCRDAKQEIRRSNRARTVPRKRFCD
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MTSHDEELSRNMDRITQLQDGIDNLVTIMYSTLSFLSRNANFKQLNPDIPITQAIPHPEGTIPPHESFNQNCEELVQDFLRKAKQIQYLISILPPHHNQQKPTKTTTTTAATTEEEQEQEEDEDDSEEFERLQADLQLAQQEYDRALSEAESLHAEIKNALRLILDHRVKLLSSSTPTTTTASITCKKD
The following text describes a protein:
Function:
Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MANPRQRRKARSGSTLKPSLNAKKQMKKKLARAPTIHGADVLKDNYDPKLTLRQNYARLGLVPSLDVRPNTGGTERAPSSISASSSKEGQAAVRKGMARVIRDDAGNIVDIIEADEHDQDETAWGKPLPSSIADRSDVPTFMPVSQPASNPDALQQLEQIASQAAPVERHTSQKESQWLVELVKKHDDDTQAMAKDRHLNLWQKTEGEIKRAIRKAGGFQALRTSA
The following text describes a protein:
Function:
Appears to be specifically required for the splicing of the terminal intron (bI5) of the cytochrome b pre-mRNA. Can also stimulates the splicing of the omega intron of the precursor of large ribosomal RNA.
Miscellaneous:
MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
Subcellular Localization:
Mitochondrion.
Sequence:
MVNWQTLFMVSLRRQGSSSRYRYKFNMENITHQVFPRCKQAFKKTNLSYEYCDLEGVLYNISLTDLQKLLLRDINAPREHAFKIVRTDLTQKSSKKRIQHWERIAPMFDHPLSLYEKLFSEMDEDFKPSFEWQQLIRVRCKDDKLKLQRVIWPKSIFSNFCRGIGVKKSTYDRLLEQNNGEVPMFVNPANAKPLPLFQVSDEAMIGEFDGIGIFPYFVDKHREFFVTEVDKLKTKIASPLCTLNERKRIEKANAGRILANEEGKPFYLDANSATTRIAGGNVVTLKQLLERSVSHKTLWSKQSNKDRTCPGDILRATILSNDFSIRQLRAEFCKNFILYNIFTILQRNKKSIRSFSGNDNAPSFQFSWNVWDSYIWKQYQETESMKIPTDQASLINYKTKYDSFLHDLQTYSALVISEMKWNQFSIFQNDETTLSRFEHITLILQTVLTKSKMIRIFQPNLYKFMQDDLRPTLMELVGFTESINATIEPGFANEQSLQSANGLKKLANQLLYFEQEIYGEKFRVNRPIQLRPITLSANYKIVILDKKNAIPEIFQTLLKFMTQITTYFVKDLSEVELHGHMHCIDKKMLDKSKFMYLYEEKSNEEVKAASPQKEKIVDNIIGLLSNDEEH
The following text describes a protein:
Function:
Involved in glucose repression of glucose metabolism genes.
Subcellular Localization:
Nucleus.
Sequence:
MHKHTDKKRSTPYSGPDAPRPYVCPICARAFHRLEHQTRHIRTHTGEKPHACDFAGCGKRFSRQDELTRHRRIHESDRPKGKRGRRKAHSDEGAARAPPVFVVGEEEARGECGSGSTSPVWDTPGAVELPPLGQSKSTSAIQQLRVVAKSPPPRVKLNALSSLQRMTPLKTQPRAPGGGPQVTFYLDGPSLGALPAAPAAAQAGPEQAAAPALPLARPQSLMQLSQLLPQGSFTNIAKHFDGPASNPISRSSSNTSISALTLGDYDEYSRVRKKSRTGTPSRRNSSSTLPDLRTHLPGPSADFSSELQRRLRLHVDATHAADHVPDQYCKYVDSAGPLATPHKSLKNSPLQSPPSGAHQYDSVVLPPLRSLPLPFLDYTHPGHPAPSAR
The following text describes a protein:
Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFNIPDEKETRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPGASNFSTLPKISPSSLSNNYNNMNNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETKGASAATGIPLESDEDSNDNDNDIENENCMHTN
The following text describes a protein:
Function:
Involved in copper export.
Miscellaneous:
MISCELLANEOUS: The copZA operon is activated by CueR and indirectly repressed by YfmP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATETSNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVANAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTARLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAYKALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGKLFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVDGEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHIIKIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAVLVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGKPRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVGAGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVAVADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAEIARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIADAIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRLQKVK
The following text describes a protein:
Function:
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is required to anchor melanin to the cell wall, for maintenance of cell wall integrity, and for proper cytokinesis. Chitosan offers an advantage during infection as it is less readily detected than chitin by host immunosurveillance mechanisms.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTGILNTLCTVLACLSVGIVGSYVAHPNRDPQVVKLFTRQGVANQYPPPDIPGPRPRAEWIDALNREKQAGRIPHLKPSIKTADQSVKYDPGVNGSDPKICSWTIGCRSPTDITDAPAGMMGISFDDGPEPASSQLMEFLKSVNQTATHFMIGSRIQQSPDAFAVALKQGGHIAVHTWSHPLMTTLSDTAVLGELGWTLQIIFDLSGGRLPAFWRPPFGDVDNRVRAIAKNVFGLQTVIWNQDTNDWCLTPHNTNTCGAEGPSNEAALDLEMTRFVNMPKNPGLIILEHELTIHSVRGFTHAWPAIQKAGWDTRPIPSLFNAPWYQNAKGAYDEAIHLTSLLNASEVVASARARLADTSNSTSANSPLNSTVPVPPAITSPQVRGSISGTSHKRSAFQILHLIFVQGLILTVM
The following text describes a protein:
Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
Sequence:
MESMLNDNNGDDLFGAGAAPAGSQDGVAQPENIETPVENQENQEIAENTPQEQQENEDDIYAAYNEPAAEPEKVSALVEWQEKKNVEIAQIDSKEEEDIQKMKQKANDDLAAYYKKLEEGQESRKKHNLDVDKETIASLEEKHDNQWEGVVSFIDFNRADLHVKDVSRMKTLLLQLKH
The following text describes a protein:
Function:
Transactivator required, together with HSP101, for long-term acquired thermotolerance (LAT) maintenance, probably by regulating heat-inducible genes expression, thus being a cellular component of thermomemory.
Sequence:
MAAYYRWKSFEENEDRPEKPRRYGVTEMRGPHYSVLSQNLLQEIFESMGQFVDGLKFSGGSNSLIPKSFIKQAIEMAHEHGVYVSTGDWAEHMLRSGPSAFKDYVEECKQLGFDTIELNANLLEVPEETLLRYVRLIKNGGLRAKPMFAVKFNKSDIPGRNRAFGSYVVPEPRSSEFVEDIDLLIRKAERCLEAGADTIMIDADDVCKYADSLRADIIAKVIGRLGIEKTMFEASDAKLVEWFIKRYGPNVNLYVDHSQIMDLECLRGRHLGKDHQSVLSSSYFLF
The following text describes a protein:
Function:
Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.
Subcellular Localization:
Secreted.
Sequence:
MSSGGLLLLLGLLTLWGVLTPVSSKDRPKKPGLCPPRPQKPCVKECKNDWSCSGQQKCCNYGCIDECRDPIFVN
The following text describes a protein:
Function:
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.
Sequence:
MGHDVAEKIWLHGVLKVTILDLDLEKLFHLWANVNDKLGGSFATVELPPVQMARTRAEQCHHGVIAWNECLRVYTANRVSTVDITITSGHHSRPQGRANIPATDILLKRHLEGWFTIDGFFKSIGKIHVIVDFEPADENPLWGNGVGENFPGVPHTFFPQHRACLVTPYQNSHIEDDFIPPIAMQGGKHRIPGKYWKELHHAICSAKKFVYIAGWSMFAKISLVRSPDGELGETLGELLIRRAQEGIRVNVMIWDDKTSNLHSMLKSFREGIMHTHDEDTEKFFTNTDVACLKCPRDPRADAFHLAEGFVFTHHQKVVVVDAPALPPYSPEQRRIIAFVGGIDLCGGRYDTPSHSLFRTLTTVHRKDFQQGCIPGAALKSGGPRQPWHDIHSKLEGAVAWDAHTNFVQRWLCQAGKINEHLLVSVDPEASEFCPPSPAVEEHHPAAWNVQLLRSIDTTSVVGFPDDSSAELVLEKGLVREEKDLVDRSIQDAYICAIRRAKHFLFIENQYFIGSSYGWKDLPDWHTAAPHLIPMEIALKIVSKIRAGEHFCCYVIVPMMPDGAPDGPSVQDILHHVKETMQMMYQMIGDALREVGRLSCRPTDYLCLFCLGNREVKEGHELIPDDPPQEGTHYWLSQENRRFEIYCHAKLMIVDDEYLIIGSANINQRSMDGGRDTEMAMGSYQPQHTLHGSLSDEAGPRGEVYGFRLSLWFEHLGCLHPEFDHPGTVKCMRKVQELAAHNWQEYIRPAPVLQDLPGHLLIYPFNVTEDGQEVYTESGFHHFPDTDAPILGAGIPKLPGILTA
The following text describes a protein:
Function:
Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge.
Subcellular Localization:
Cytoplasm. Endosome.
Sequence:
MTLTTTTTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGASDGDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLREAEASLSLKDLKQRVQELSSQWQRQLAENQRSESERTTNAVDSTPKKLLTNFFDSSKSSEHTQKLEEELMTTRIREMETLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKEELEMAVTREKDMSNKAREQQHRYSDLESRMKDELMNVKIKFTEQSQTVAELKQEISRLETKNSEMLAEGELRANLDDSDKVRDLQDRLADMKAELTALKSRGKFPGAKLRSSSIQSIESTEIDFNDLNMVRRGSTELST
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the methylation of the guanosine nucleotide at position 6 (m2G6) in tRNA(Cys).
Subcellular Localization:
Cytoplasm.
Sequence:
MDYYVTLSPGLEKISKNEIESFGGKIKEIRENKGRIFFSGDLKLIPKINYLSRTIERMNILLHREEIPNIALDDIYKRVYNIDWTEWIKENQSFAIRPLRAGEHNFTSIDIGRVAGEAVIKSYQRDKNIRLKVNLDEPDVIVRVEVIFDELIVGIDTTGDIALDKRGYRVFNHPAHLNATIASSLVYLSDWKDDEMLLDPMCGSGTIPIEGALMKRNIPPGKFRENKYGFKFIDIFGYELLDKIKKEIVENKNIYKIIGLDKNQKYLDGAKDNAKNAEVLDTIEFICGDATKLHEKFNESDVIIANPPYGIRIGSKRSVKKLYDEFLSSAKEIMHGSSRLIVITAEDKMFKDAIAKNNFEVKEEFNVMFGGLMTRVFYLTL
The following text describes a protein:
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MAEFTLQEHLLALSDPPLYQISAELDIPSLRTSSIDSSLSSAIEEIAGDPESIVNSSPSTFDVFRSILKHADQPNVDSGILTKLLDVIVSGLSYHSSTVMAIVNGQGFGAEADMDAPMVHKQPLEMWAFLLQWFVNAAERGAGKTNDEPRQAMTGRGKKKTTKTAGGAGISTSFVFSDHLPLVLGTMHKTLRIPTSRLWRTSSEREAFISCFVKPAYQLAETEAYLKISEIRLGIFKVICLAVKFHQHAFGAQTSIMQNLTYFEHLSEPMAELLAILEKEFDFSQLGEEVLRDVAGKSFAHNDAKGPRSFSRFLVRLTELSPRMVQKQMPLLLAHLDSDAHPMRMAIVEIIGILIKDISSSDEGDEEQKTKQIQRFFELLMERFLDLNSWVRCKVLTTLIKLCDLPAKFPKQRHQITELTIRTLEDKTSSARRYAIQLLCKLLETHPFGALHGGTLNLQEWQERYEKVAEELKKVDAQELEMAKREVGVEDDDEEGEDDEEQKEDEEGTKFNKEKEDGDKEEDDEAQNESTPKPKKKKPRQSQLDLSAIQSEQASIDPNLITKLRLTKKYYGDALRFINQLESAIPTLCQLLVSTTKTEVLESMRFFRVAYEYDIASAEQGIKTMLHLIWTKDNNATAGEEGEGKGIRGSVIECYRSLYFDVVPDLSPKQQVNRITKNMIERTYGATLAELTSLEELMRTMMGENMVHTDVVNKLWQVYSTEQEIPKAQRQGAIIILGMLALAKKEVVTEKVDKLLKIGLGPLGMQDLVLAKYTCIALQRLSGSAKKVKGSLQDKTMRLPMDNPIFTKLQDIIEFSPKSPQWFSMAEQAVNTIYLLGEQPDRLCTKIIKDLTAKVFEAPEKEMEVEKEKEREEEKNGELENGKLDNGKQEITENGDVSVRADSEPETVDDGETSQTQSQLAPTNEEVALLKAQASSFRIAQMVFIVGHVALKHIVYLELVEREFKRRKDEKAKEKAAAKAAEKDQNDLDAVAGNAEDDIGDLISTMKEKELLYGDKSLLAVYGDLIAHICASPKKYKYPSLREAATLSLSKLMCVSSQFCEQHLPLLFKILETSKDPVVRSNIVIALGDIAVCFGNLIDDNSERLYQGLADTDLVVKKNTLMVLTHLILNGMIKVKGQLGEMAKCLEDPDQRISDLAKLFFTELSTKDNALYNNLQDVISHLSIGAHAVDEGTFERTMRFIFTFIEKEKQAESIVEKLCQRFRQATEERQWRDISYCLSLLPFKSERSVKKLIEGLPFYQDKLHEETVFRRFTEILAKARANKASNKPETELQEFERILNEHQAKGLEDQALEADVLRKAKAAKRRAAKRPPAATARTTRRKQVIEEDVEEDEEETPTVDEEEAEEEEAFAPRKKVTARKAPPRRGGRRKKVVESEDEDEEDEDEDDE
The following text describes a protein:
Function:
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKLIRVFKLNGFLKQSRVFRVFCLIIACYGLYIILNFIFYKEIFFKGSHLKCNSTGSQNVINEKLSTPKDDVNQNLTHGVGDDNLNLNYSKNCGLPFECTYDEFPIHLYTGRANSEKPRICINHLYSALPYFKNLGRGFNVAVVDPKAVKVVRFGNFDTFATESKKLEEFLELLEAGFLAVFVVYDDGSTRLSASVRDVITSLGSSLIMNLAFRDVWVFVGRKNLSGFSPIEHIEYSIYGWPRPISLRTCVKRNFVGVEVRADVTARVNEGRRKFCVESQFDNSFCSAENIDEPLSTLPLFDPALENSSLFSAPVVIVPGPDINVFRMQVEALLFNPGILKENIHVFLPENEELFIKLSVLLDLKIHLLVNSFFEVDDYADIFLGSFKHSWENFNAQYIVFLEQHVIPSNNFLSFMAQCMDVLQNDSSLMAASAWNPLGLSLTASNENRAIRSGVFPGVGFIMSRHVYDTHLKPRWSEFNHISALDGWSIPGLTVDTIIPEVSRVFILPNFHPGMASLFTKIVVSIDEKLETKIDDPNVLKKGNYSTYLENLISKSAIIPEKDVELFCRERMLCSDDDHKHCKSIDSLFASNIGPSYVVRSAERTDQSSPSALRNLLTCLVGVDFHQNFERTINAIQYQHIVKLSLVGRDIIIITDKYTPGKS
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Subcellular Localization:
Membrane.
Sequence:
MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDNPIGLAAGFDKSCEVPKALEHLGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFNNIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYIKVIDTFKHDVSFFTVNISSPNTENLQNFHDKDEFSMLCQALTAFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITETFDGIILANTTRQRDGLTSANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTGGVFSTEDAIKMMRHGASLIQIYSSLVIEGPGLTKKMNKGIARYLKDHHFDNVSDIIGLDA