lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
Subcellular Localization:
Mitochondrion matrix, mitochondrion nucleoid.
Sequence:
MAPKSFANEIMKTTLGYFQRRPATWKNTVGISRSPYCMPFHSLRFSSSDLSHNELLERFNMFNKQQLLNMKGIGQLKANLIIDYRKSNGSFSSLDQLQQLRGFSSKLIDRLLKSENHLSIRRYPPLIDQDLRKSIQSIVSIDLGFKNFAYVHINRELTLLDWRKLCFPTMTSNSLQTTYENVIGIRRTLPAADVYVIEQASAIPHHGASFNTGIPLRILEAFLYCVLQPNKVVSMNAKTVQSYFNLSKGPQKKTDAINKVLELMNGKSKCHNVTFTNQQISEFTSITKKDDLSDCLLQALTFYDKEVFDF
The following text describes a protein:
Function:
Involved in salt tolerance by producing GG-phosphate from ADP-glucose and glycerol-3-phosphate (G3P), an intermediate in the synthesis of the osmolyte glucosylglycerol (GG).
Subcellular Localization:
Cytoplasm.
Sequence:
MNSSLVILYHREPYDEVRENGKTVYREKKSPNGILPTLKSFFADAEQSTWVAWKQVSPKQKDDFQADMSIEGLGDRCTVRRVPLTAEQVKNFYHITSKEAFWPILHSFPWQFTYDSSDWDNFQHINRLFAEAACADADDNALFWVHDYNLWLAPLYIRQLKPNAKIAFFHHTPFPSVDIFNILPWREAIVESLLACDLCGFHIPRYVENFVAVARSLKPVEITRRVVVDQAFTPYGTALAEPELTTQLRYGDRLINLDAFPVGTNPANIRAIVAKESVQQKVAEIKQDLGGKRLIVSAGRVDYVKGTKEMLMCYERLLERRPELQGEISLVVPVAKAAEGMRIYRNAQNEIERLAGKINGRFAKLSWTPVMLFTSPLAYEELIALFCAADIAWITPLRDGLNLVAKEYVVAKNGEEGVLILSEFAGCAVELPDAVLTNPYASSRMDESIDQALAMDKDEQKKRMGRMYAAIKRYDVQQWANHLLREAYADVVLGEPPQM
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Sequence:
MERRRAAWAAVLVAVAACAALPATTTANKIKVNWLPNTNYSGWEQEHGPFYKGDWLVFYYTAGQADVVEVNESGYNRCDASNAIYNYSKGRSFAFELNETKTYYFICSFGYCPGGMRLAIKSQNLPPPSPPPSAQHHRSAALAGPRAGVALYAAVAVLAALLRAV
The following text describes a protein:
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Sequence:
MLKSFGIISGFLLISQGKVNSLTENFNASRHALCILFPDSNSGVNGVVSFSQEHINAKTKIAAVVRGLKPNSLHGVHIHEFGDLSNGCATAGPHFNPFEQEHGGPLDEKRHVGDLGNIKTDERGNGYLAYEDNQIQLYGEYSILGRSVVVHAGQDDLGRGNQKDSKTTGNSGARLACGVIGLASGFKNLQPYK
The following text describes a protein:
Function:
Acts as an effector of RAC1. Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. May also play a role in miRNA silencing machinery.
Subcellular Localization:
Cytoplasm, P-body.
Sequence:
MYCCSAQDSKMDYKRRFLLGGSKQKVQQHQQYPMPELGRALSAPLASTATTAPLGSLTAAGSCHHAMPHTTPIADIQQGISKYLDALNVFCRASTFLTDLFSTVFRNSHYSKAATQLKDVQEHVMEAASRLTSAIKPEIAKMLMELSAGAANFTDQKEFSLQDIEVLGRCFLTVVQVHFQFLTHALQKVQPVAHSCFAEVIVPEKKNSGSGGGLSGMGHTPEVEEAVRSWRGAAEATSRLRERGCDGCLAGIEVQQLFCSQSAAIPEHQLKELNIKIDSALQAYKIALESLGHCEYAMKAGFHLNPKAIEASLQGCCSEAEAQQTGRRQTPPQPMQCELPTVPVQIGSHFLKGVSFNESAADNLKLKTHTMLQLMKEAGCYNGITSRDDFPVTEVLNQVCPSTWRGACKTAVQLLFGQAGLVVVDTAQIENKEAYAPQISLEGSRIVVQVPSTWCLKEDPATMSLLQRSLDPEKTLGLVDVLYTAVLDLNRWRAGREQALPCIQIQLQREICDFGNQADLPSGNGNKSSGGLQKTFSKLTSRFTKKASCTSSSSSTNYSIQNTPSKNIFIAGCSEEKAKMPGNIDTRLQSILNIGNFPRTTDPSQSAQNSSNTVANGFLMERRENFLHGDDGKDEKGMNLPTDQEMQEVIDFLSGFNMGQSHQGSPLVTRHNSAATAMVTEQKAGAMQPQQPSLPVPPPPRAPQAGAHTPLTPQPGLAPQQQSPKQQQPQVQYYQHLLQPIGPQQPPPQPRAPGKWVHGSSQQPAQAVGAGLSPLGQWPGISDLSSDLYSLGLVSSYMDNVMSEVLGQKPQGPRNNTWPNRDQSDGVFGMLGEILPFDPAVGSDPEFARYVAGVSQAMQQKRQAQHGRRPGNPRGNWPPMDDAHRTWPFPEFFTEGDGLHGGWSGAQGDSASSSDETSSANGDSLFSMFSGPDLVAAVKQRRKHSSGEQDTSTLPSPPLLTTVEDVNQDNKTKTWPPKAPWQHPSPLPSTLPSPSAPLYAVTSPGSQWNDTMQMLQSPVWAATNDCSAAAFSYVQTPPQPPPPPAHKAAPKGFKAFPGKGERRPAYLPQY
The following text describes a protein:
Function:
Transcriptional repressor. Acts in a ventral signaling pathway downstream of bmp4 to antagonize the Spemann organizer and ventrally pattern the embryonic mesoderm. Represses transcription of the dorsal genes gsc and otx2 (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEKRPYSVAWLSESSQRKPLCTNVDLLGYKSGNPDLPPNREYNVSLPSRVILPTPDYREKENYCGRNVHNGERSPPVRDQLHFHPAPQELTTSRRTSIEVSAESSTDQRVIGMTDTNKKTISVCDEDAASRARTKFTAEQLEELEKSFKENRYIGSSEKRRLSKVLKLSENQIKTWFQNRRMKFKRQTQDARVEAFFSGLYLPYYGYPDLPTPGYSVQSEFPVLAPQTMAASSIPFGPLHSTVMSPGLHPAIPSANLGSYPCSSMLVRPILNEPTRQRYSPY
The following text describes a protein:
Function:
Isopenicillin N synthase; part of the gene cluster that mediates the biosynthesis of penicillin, the world's most important antibiotic. IpnA catalyzes the cyclization of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) to form isopenicillin N (IPN) that contains the beta-lactam nucleus. The penicillin biosynthesis occurs via 3 enzymatic steps, the first corresponding to the production of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) by the NRPS pcbAB. The tripeptide ACV is then cyclized to isopenicillin N (IPN) by the isopenicillin N synthase pcbC that forms the beta-lactam nucleus. Finally, the alpha-aminoadipyl side chain is exchanged for phenylacetic acid by the isopenicillin N acyltransferase penDE to yield penicillin in the peroxisomal matrix (By similarity).
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MGSVPVPVANVPRIDVSPLFGDDKEKKLEVARAIDAASRDTGFFYAVNHGVDLPWLSRETNKFHMSITDEEKWQLAIRAYNKEHESQIRAGYYLPIPGKKAVESFCYLNPSFSPDHPRIKEPTPMHEVNVWPDEAKHPGFRAFAEKYYWDVFGLSSAVLRGYALALGRDEDFFTRHSRRDTTLSSVVLIRYPYLDPYPEPAIKTADDGTKLSFEWHEDVSLITVLYQSDVQNLQVKTPQGWQDIQADDTGFLINCGSYMAHITDDYYPAPIHRVKWVNEERQSLPFFVNLGWEDTIQPWDPATAKDGAKDAAKDKPAISYGEYLQGGLRGLINKNGQT
The following text describes a protein:
Function:
Potential calcium sensor.
Sequence:
MSHLSILTFKYNLAKLRFKPSRPAGRLLSARDRQQSDLMMYKPDEEEMAKVFDKIAGEPGRISRSDLQALLQRFEKADAAGEARRMVCAADSNKDGYMDLEEFMEVHRNGVQLGDIRRAFFVFDRDRDGRITAEEVMDVLRRLGDSCSLEDCRKMVKEIDRNHDGFVDMDDFMAMMTRPRKRM
The following text describes a protein:
Function:
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Subcellular Localization:
Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Postsynaptic density. Cytoplasm, cytoskeleton. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity).
Domain:
The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A.
Sequence:
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVAAQFSAQPHVNGGPLYSQNSISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
The following text describes a protein:
Function:
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.
Subcellular Localization:
Lysosome.
Sequence:
MLKMDREKLIVPNQIGYLILKEDGAVLESGGDLKNDERSANVIMGLLNLTETIDESFMPSSSCERITIDYEHHYYSICMSNRRIYIIKISKSQNGVTTTTSSSSSNSVYNDASDSGAVLA
The following text describes a protein:
Function:
Putative N-acetyltransferase. May act on ribosomal proteins (Potential).
Sequence:
MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENPSSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAKEFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGLYVNGMHHDLVYYSLLKREWEGEK
The following text describes a protein:
Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MAKGGGSQLSQLKSKLHSSGVTDRRQLSKKSRSRKGGQDEKDAAEARRNKINAIVADLNPFEQKVTKPKHEVLGRKIKGAVGRPGAAKASGLAQRRETLLPEWQARDRTGTFVDRRFGENDANMTPEEKMLERFATEKQRRAAKGAAFNLNDDDDLLTHYGQSLSGLDDLADIRLPEDDEDEDDSGRMTAQGHFGGFGDNEDGEKSKADVMREVIAKSKFHKLERQKVKDADDELREQLDDELADIRGLLFEQPAVPTPAPPIDTNAKPKLSVFPGPATGANATAVAGVNTDATAGQDKPTSSYDTFVRELAFERRAKPQDRLKSEEELAAEQAERLRKAEKARLKRMRGDESDDEADEDDDGGKRRKRSKGANSSSAPKRAAQADDLDDDFELDGMTAGEVYGLGAGLAESGTVDASDAEEDDDTEDDNDEEGQDDAAEGVEIEEEDDDDDEEEDDFADLADADDAIRIGEDEDSEQEGDHEALTSYSKAEAKTGKTDTVTKPKSTPVTQSKLPFTFSCPATHDELLSLLETHQINPKHIPTVIKRIRTLHHPSLAEDNKYRLQAFIGVLIDHTLHWAGQAQMHQSTTGQKHKLAFAIVNSLIPHIFSLSQTYPAASAEHFVNKLALMQRNLSRGLAKGPTEDNARTWPGLPELTLLRLVGTVWPTSDKQHNVTTPLALLIAQYLAHARIRSVSDLASGLFLCSLVVSNEVESRRLFPEALNFLFSSIAILASFGQEKKQQRETLAKIRGVAEEYGIPTPDVDAVHTRHLRLSGEDVVEATDQAVDLPSLIITKSGADSQKRTELLSVALTLTSKFSELYDGSTSYIELFTPFSVLLSASFSTASSTVSASLSRSLHLASTSRRYLRLQAHRAIAIASHVPKFDQQGYNPDRKSALDPDVERVQIQKMKALIKKERKGAIRELRRDNQFIAQVRKQDQAEEDQTYKRKMDKIMSTLQVERSEQKQLERAKANIKRRAGKK
The following text describes a protein:
Function:
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template-independent 3'-terminal nucleotidyl transferase activity.
Miscellaneous:
MISCELLANEOUS: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA.
Sequence:
MGTFTLHQGQTNLIKSFFRNYYLNAELELPKDMELREFALQPFGSDTYVRHLSFSSSEELRDYLVNRNLPLHLFYSSARYQLPSARNMEEKAWMGSDLLFDIDADHLCKLRSIRFCPVCGNAVVSEKCERDNVETLEYVEMTSECIKRGLEQTRNLVEILEDDFGLKPKVYFSGNRGFHVQVDCYGNCALLDSDERKEIAEYVMGIGVPGYPGGSENAPGWVGRKNRGINGVTIDEQVTIDVKRLIRIPNSLHGKSGLIVKRVPNLDDFEFNETLSPFTGYTIFLPYITIETEVLGSIIKLNRGIPIKIKSSIGIYLHLRNLGEVKAYVR
The following text describes a protein:
Function:
Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.
Sequence:
MQNSLLNTHVTTIDGEVTTLEKYAGKVLLIVNVASRCGLTPQYEQLENIQKAWADQGFVVLGFPCNQFMGQEPGSEEEIKTYCASTWGVTFPMFSKIDVNGDARHPLYQKLIAAAPTAVAPEKSGFYERMVSKGRTPLYPDDILWNFEKFLVGRDGQVVQRFSPDMTPEDPIVMESIKIALAK
The following text describes a protein:
Function:
Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.
Subcellular Localization:
Nucleus.
Sequence:
MLKLIWRPQLMLGDGLRTSNSCLRGQITRTKMCTTLLVNSAVKIQPGANTATGPSPLNIYLSLSSQWKLMHISKKMGRITLSHLRSWERCHSAFTSIYKADEMACQSMAKNKEDVPHEELDPAGTINASVEVLENNSNIQIPKRKFAIMLAYCGRGYYGMQMDLTRPNFPTIESALISALIQARCIPEMFYMQMKQLKFQRCARTDKGVSALSQLVSVRLLPSCSNPVEKINSHLPPEILIIDMKRVTKGFCPKKMCDKRSYSYMVPTFALSCCAPSVPDSNFRMPREDFHNINNLLSFYKGTHNFHNFTSRKAFEDPSSFRHMLDVSCSEPFVFHGTEFAQIHITGQSFMLYQIRKMVGLIIAIAQGIVPADFLPQCMQREKINIPPAPGLGLVLERVHFDWYNKRYGGDGFHQPISWEKSMPTVSVFWEERILPDILEGELENLSMSYWIEKLNRHNFLMFQNYKEV
The following text describes a protein:
Function:
May play an important role in the early development of muscle.
Subcellular Localization:
Nucleus.
Sequence:
MTKYNSGSSEMPAAQTIKQEYHNGYGQPTHPGYGFSAYSQQNPIAHPGQNPHQTLQNFFSRFNAVGDASAGNGGAASISANGSGSSCNYSHANHHPAELDKPLGMNMTPSPIYTTDYDDENSSLSSEEHVLAPLVCSSAQSSRPCLTWACKACKKKSVTVDRRKAATMRERRRLRKVNEAFEILKRRTSSNPNQRLPKVEILRNAIEYIESLEDLLQESSTTRDGDNLAPSLSGKSCQSDYLSSYAGAYLEDKLSFYNKHMEKYGQFTDFDGNANGSSLDCLNLIVQSINKSTTSPIQNKATPSASDTQSPPSSGATAPTSLHVNFKRKCST
The following text describes a protein:
Function:
Galactinol synthase involved in the biosynthesis of raffinose family oligosaccharides (RFOs) that function as osmoprotectants. May promote plant stress tolerance.
Subcellular Localization:
Cytoplasm.
Sequence:
MAPELESGTKKASTTQKDIELGRAYVTFLAGNGDYVKGVVGLAKGLIKAKSMYPLVVAILPDVPEEHRMILTRHGCIVKEIEPLAPSLQSSDKYARSYYVLNYSKLRIWQFVEYSKMVYLDGDMQVFENIDHLFELPDKYLYAVADCICDMYGEPCAEVLPWPKEMGPRPSVYFNAGMFVFQPNLSIYVRLLNTLKVTPPTQFAEQDFLNMYFKDEYKPIPYTYNLLLAMLWRHPEKIEVNKAKAVHYCSPGAKPWKYTGKEEHMDREDIKMLVTKWWDIYNDTTLDHKAQGSTVEANRLKEAAFSDSNISALYITSPSAA
The following text describes a protein:
Function:
Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity.
Subcellular Localization:
Cytoplasm.
Sequence:
MAQAQKGDRVTIDFTGTLEDGTVFDSTLEGAGCDTDDCESDDCGDGSCGCGCEESGPMTLTIGGGEFFEKIEEALIGMAPGEKKTVVIPAAEGFGEYDEEKVFTVERSDLPPDLIPEVGQELVISNENDEDFGVTVVEVTDESVTFDANHPLAGEDLTYEFQLVEIL
The following text describes a protein:
Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity).
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
METYAYPAFPPEYSNIHIALFKNVTNAPQIRKRLIEASQMTGPEGDKAREEVDFGFVEANLLVSKEHLLIAILSTLLYAFPSTGPAPTDPPPLSDIADPDVSSLSLSSSSETRQPKTRSHNLHSELLLLLSPNNNITDSIRRHGVSDITTNLAVVKFGKRGDRVEEVYEAMKNVVEGELIGWEGISEGTDWARVDKIYKLNELNALKTADMVEKKRTAVISTVAIKNVI
The following text describes a protein:
Function:
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
Subcellular Localization:
Secreted, extracellular space, extracellular matrix.
Sequence:
MERPAPSRLVPLPLLLLGSLSLLAARANADISMEACCTEGNQMANQHRDCSLSYTSESKECRMVQEQCCHNQLEELHCATGINLASEPDGCASLHNYNSSLETIFIKRCCHCCMLGRAAQARGQTCEPNLMISYQCGLVFRACCVKGQENSDFVRGDGTDLQDPAKIPEEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGYYFDGISRTCVDINECQRYPGRLCGHKCENTPGSYHCSCSAGFRLSVDGRSCEDVNECLNSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTFRQEKTDTVRCIKSCRPTDEACMRDPVHTVSHTVISLPTFREFTRPEEIIFLRAVTPLYPANQADIIFDITEGNLRDSFDIIKRYEDGMTVEMLQKLTFDGCLRPREEYSTWSNSPPSATFQRILHT
The following text describes a protein:
Function:
Major facilitator-type transporter, part of the hnx cluster involved in the purine degradation. The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism. The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDISYPVINAGGLKNIASQIIMEIELDKRENRPTDNVPPDDIGKIEVVDDAEMEQFYGSSTTDAYRLKSELVSQCMADIGMGRFQWKLFTVAGFGWIVDNFCSQGISAVQPPIQQEFSGIKQVSYSSVAYYVGMIIGASFWGISSDLIGRKPAFNSTLAIAGIFLCAAAGTSNFIAFSALWAVIGTAAGGNVVCDSMILLEFIPGSHQYLLTALSGWWNLGQLVVSLLAWVFLANFSCPTDATPDTCSRADNMGWRYTLITLGGLSLAFTFVRIFVFKMPETPRYLLSQGNDQAAVDAVNYVARQNGKPEPLTLSMLQAIDVRLGFTPNAEERLSTKDILKENMQEFRGEHYQALFATRKLSQHTALIWAVWLIIGIAYPLYFNFLPSYLATRFTQDSSLDLTYRNYCIQSAVGVVGPLSAAVLVNTFLGRRWMMGISSIVTGVFLFAYVGVKTPMSSLAFSCVTGLLANFANQLSEYAIMYAFTPESFPAPHRGTASGTAASLLRFGGLVASLIASETGFTTAPIYASAALWVGVGVLCFGLPFETHGHAAI
The following text describes a protein:
Function:
Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MTFWSILRQRCWGLVLVVAGVCVITFIISHLIPGDPARLLAGDRASDAIVENIRQQLGLDQPLYVQFYRYVSDLFHGDLGTSIRTGRPVLEELRIFFPATLELAFGALLLALLIGIPLGILSAVWRNRWLDHLVRIMAITGISTPAFWLGLGVIVLFYGHLQILPGGGRLDDWLDPPTHVTGFYLLDALLEGNGEVFFNALQHLILPALTLAFVHLGIVARQIRSAMLEQLSEDYIRTARASGLPGWYIVLCYALPNALIPSITVLGLALGDLLYGAVLTETVFAWPGMGAWVVTSIQALDFPAVMGFAVVVSFAYVLVNLVVDLLYLWIDPRIGRGGGE
The following text describes a protein:
Function:
Histidine kinase that acts as an osmosensor at the plasma membrane. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, the histidine kinase autophosphorylates His-576. This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1. Under high osmolarity conditions, the histidine kinase is no longer active.
Miscellaneous:
MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MRFGLPSKLELTPPFRIGIRTQLTALVSIVALGSLIILAVTTGVYFTSNYKNLRSDRLYIAAQLKSSQIDQTLNYLYYQAYYLASRDALQSSLTSYVAGNKSADNWVDSLSVIQKFLSSSNLFYVAKVYDSSFNAVLNATNNGTGDLIPEDVLDSLFPLSTDTPLPSSLETIGILTDPVLNSTDYLMSMSLPIFANPSIILTDSRVYGYITIIMSAEGLKSVFNDTTALEHSTIAIISAVYNSQGKASGYHFVFPPYGSRSDLPQKVFSIKNDTFISSAFRNGKGGSLKQTNILSTRNTALGYSPCSFNLVNWVAIVSQPESVFLSPATKLAKIITGTVIAIGVFVILLTLPLAHWAVQPIVRLQKATELITEGRGLRPSTPRTISRASSFKRGFSSGFAVPSSLLQFNTAEAGSTTSVSGHGGSGHGSGAAFSANSSMKSAINLGNEKMSPPEEENKIPNNHTDAKISMDGSLNHDLLGPHSLRHNDTDRSSNRSHILTTSANLTEARLPDYRRLFSDELSDLTETFNTMTDALDQHYALLEERVRARTKQLEAAKIEAEAANEAKTVFIANISHELRTPLNGILGMTAISMEETDVNKIRNSLKLIFRSGELLLHILTELLTFSKNVLQRTKLEKRDFCITDVALQIKSIFGKVAKDQRVRLSISLFPNLIRTMVLWGDSNRIIQIVMNLVSNALKFTPVDGTVDVRMKLLGEYDKELSEKKQYKEVYIKKGTEVTENLETTDKYDLPTLSNHRKSVDLESSATSLGSNRDTSTIQEEITKRNTVANESIYKKVNDREKASNDDVSSIVSTTTSSYDNAIFNSQFNKAPGSDDEEGGNLGRPIENPKTWVISIEVEDTGPGIDPSLQESVFHPFVQGDQTLSRQYGGTGLGLSICRQLANMMHGTMKLESKVGVGSKFTFTLPLNQTKEISFADMEFPFEDEFNPESRKNRRVKFSVAKSIKSRQSTSSVATPATNRSSLTNDVLPEVRSKGKHETKDVGNPNMGREEKNDNGGLEQLQEKNIKPSICLTGAEVNEQNSLSSKHRSRHEGLGSVNLDRPFLQSTGTATSSRNIPTVKDDDKNETSVKILVVEDNHVNQEVIKRMLNLEGIENIELACDGQEAFDKVKELTSKGENYNMIFMDVQMPKVDGLLSTKMIRRDLGYTSPIVALTAFADDSNIKECLESGMNGFLSKPIKRPKLKTILTEFCAAYQGKKNNK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MNNINKQLVKDIYQIGLEHKEAISIDSLEEIYEKKKKGKLKRNEIVYALNILENARACSIKNENNTIITRMRNEQVTKKLKELSDIDFLIFTKVENSQNNGIWTADLRKQTKLLIHQVQKGVKLLCENKLIKQVNNIHVKNRKMYILYDLEASEKVIGGSFYTDGEFNKKVVDYIRENICFYLYNNNNSSVPSVINYIKKLNNSVDYFSENDIYRVIKTLSYEERINIYKSNNDEELIYYYNNEKKNFLYNFPCFSCNLFNKCNSDINTTINPRSCMYLNFYLNLENE
The following text describes a protein:
Function:
May be involved in the turnover of nuclear polyadenylated (pA+) RNA.
Sequence:
MFINNTEALKVWLTAVLEPLCDADPAALARYVLALLKKDKPEKDLIVSMKEQLDVFLSEETQPFLDRLFRVIKSEEYLKCAPAPAVPAAPVVVSNGATVGAVPSSTTSSGSSTAQAQAASTTPAGASANHHYAEEVTSSSRTTIKREFTPPLQESSSSGTGGRSSKSVASSAGSNYSSAAGSGGVTATSGSITSERSTSSSHHHHHHHSGGGGGTSERSEKGRGSETTSSSGAPSVSSSSGGGGTLGGGASSQKSSSTHHQQHSPIKGSGKDDHGKESSSSSNNTRRSRRTQNRSRSRSRSRSRSFERPRDTRRSRSRELQQRPRGGGAGGGSLGGSGNDSKSGGSRSSSYRNKSPLRGSDSFRRYERKGYSDRRNSGPNASGTMAGSGAGTNAASSGGGGSSGSGGGNGVGSSRSQRIRSHSRSRSPSPNSDRRKMARSMTPVRQAAVAAAARAVGGALVAGDTVASAGGGMVVDGVAVVNPVSALVGPPGVTGGVPIIPVGGVVPTVAPVPPPSAGALDRVLNAAAGEGGAATAVPLGGGGGSVKRQRCRDFDEKGYCMRGETCPWDHGADPLVLEGLNNPAMIAQIRGPIAAEYSPDAPALWNKHPNVQQGPPGMGGGGGGGGVATGIRPPLAQRLGGGGFGPRGGPGPGGMGVQFRGVSPGFPMQGGGGFAGNPIGATPLQRELISVPVVDANKGGDVSADHRSNRFEPEDAVAIADAGPMMMGGGGKRKMPMHNRHGPRPGGGHGGGPGGPGSMQMMNTQHNCSLELRKIPRGLNEISHLNDHFSKFGKITNIQIRYDNDPEAAIVTFSSHAEANVAYRSTEAVLNNRFIKVFWHTPPAGGDQPAITASAKTEHSLRRTYPNQYSINNNLSSAGATGTTQTGPIVAGGKTLQAKDDANPLANGNENLAPQQQQQPGGPKAHGGNNANKYISPGTGAPLQGGGVGGNKGSNRAQNEMLRKRQEQFTKGINERKVFLMDGYLKEQRKLLELIVTYEVSDPRRPQLKESLDELQVKINNLRKEIEQDHQLLKANTARGPGPHGPKHKTKEQHDKEMLDAELEQIAQETRTFRTPDGPAVAAAAAATIAPGQKGPYGGGGRKGGPVGRVAPPGSTSVDRRPTTILITGFVEEEADSLLDHFKQFGEVTKHQLDKAEPSLTIGFSTRPVAEKALARGKLFNKKTLTIVWQTTVAAAAPAPAAASLAGASAGGAGTTATTADSGKEQGGRGDGNPLVHSSSGSSDGGDGASLKQHDSDGAERMGLGSGGSAADQLHSSSMETLTETDELIEMPIMVEEEEEEDDIEPERSWRR
The following text describes a protein:
Function:
Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.
Subcellular Localization:
Vacuole.
Sequence:
MAPPAEISIPTTSISTPSSESGGSSKPFTLYNITLRLPLRSFVVQKRYSDFLALHQALTSLVGSPPPEPLPAKNWFKSTVNSPELTEKRRVALERYLRAIAEPPDRRWRDTPVWRAFLNLPGGASGANAAASTAGSGSGIEGKIPAIGLKDANLAAASDPGTWLDLHRELKGALHEARVALGRRDGATENMTKLEAGAAAKRALVRAGSLLGALQEGLGVLKSSGRVGEGELRRRRDLLAAARVERDGLDKLSSSLAHASREAARQASVSGPSGSGSSSGEAGERAKLFAGSSGAGGGSVRGGRVLGAPLPETERTRELDNEGVLQLQRDTMRDQDMEVEALARIVRRQKEMGLAINDEVERQTNMLDNLNTNVDVVDKKLRVAKGREEDEENNDDDSLNRMMFIMSSEEGSVAEVVALPTTVAQGDQHEAIHRPRNGRLRLRRDQWLYELSLDDDGHDDHSSTKDEKKSRTASQQQQQGDEGKGKRNEGLRAKGRPSGSGGGGGEEGNMFDAFLLLCVKGVLAGVQGFWLLQWVLGRLSDVLTCVVEFGLLLLGQPSESFG
The following text describes a protein:
Function:
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Sequence:
MTSRMTMLTMGPIGQLFGLFSILLLVFLLRLIHLIRSTHQLQSRSQSSGRLQTCKLTILLGSGGHTGEMIRLLSGLPFDRYTPRTYIISSGDSLSRFKALELERLKQAGQYEFLEIPRARRVNQSFVTSIFTTITSLLVCLRFISIKPNFSPCLVTPQEDSTDEQACSSAVILNGPGSAVPIALSVFLPRLITGKLKPRLIYVESLARVKKLSLTGILLLPFMDCFIVQWKVLQAEIHRSRLYQVLYRLKLVSAITFDGWMV
The following text describes a protein:
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Sequence:
MSAIRPIMRPFRMTTPFRQSSSFRQLRITWAPSFGAGSSRCLTIGLSPSSGSGSSFRRRLLYPLAILPVGLLLLPVLSADSEPDAIPVPTSLSTSTTSELLRTWFIYAIISMPGVVDYSPAVLNFFINSSLRGPTEWFVRHTFFGQFVAGETVEGCMPTLKAFRERNVGAMLNYSAEVDESQLTETAPSKEERNRKEREKKFETIITALEAAGEYERSLPVDQRGVTGFALKITGLIDPNILERASYTLLRLRPLAKSNSPTAPNTHLFVPYPGTPETLDRQVVARTPELKLGDGKELLALKGKWDDMGVLEKDPGLQEGDLEELRQLWYKLQKIGHKAKENDIILYVDAEYTWYQPALDAYTLLLSQEFNRPPTSKEEIWTGPLIYGTYQTYLCRQPTHLIHAIQHAEVNGYALGVKLVRGAYFEQERKKWSDEGRVGAAPIWPNKSATDVAYNGSISTIMTTLASQLKSPHPELALSVAFGTHNPESCDLVCENLLRNGLAKEVGEAKMLRLREDVRGKVRIAQLLGMKDDLTDRMARKFVNDGKPVALKYMAYGKLSEVMPYLGRRAIENKSLMSGDHGAAAEMRRVAAELKRRFFGGSV