lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Steroid phosphatase that dephosphorylates ecdysteroids such as ecdysone 22-phosphate (E22P), 3-epi-ecdysone 22-phosphate (E22P) and 3-epi-ecdysone 2-phosphate (E2P). Likely catalyzes the conversion of inactive phosphorylated ecdysteroids into their active forms (By similarity). Shows high activity towards ecdysone 22-phosphate (E22P), but is also significantly active against 3-epi-ecdysone 22-phosphate (E22P) and 3-epi-ecdysone 2-phosphate (E2P). Also displays acid phosphatase activity towards 4-nitrophenyl phosphate (pNNP) in vitro. Has no activity towards 3-epi-ecdysone 3-phosphate (E3P).
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Sequence:
MATLPPRKSQTPTRICISKQHLTPLQTLLQMGFPRHRAEKALASTGNRGVQIASDWLLAHVNDGTLDECAPREYIIYACPTGPFLQQLEEFWAKSRQMCGWNGAHNYVPHITLVSFFKAPDECSLQLSKALKQVVDMTGALLDRPLKLEPYMSQNFMGFFVAEEDANYLKRLALQYVKEVSNSIISDTYEQLDAIVACFPWCGAVSSGTRCIPRSSRSISLEPHVKSLHLTLAYQFPQAQFNALKALVETLDASCASNWELRLYSRDPRLATKQVQKVVYPHNPHETDELELRIGDYIYLNTEVVDSSSDGWAEGISWLTGSTGHLPVNYTERTAESDAWTLHRVVQLSKSVASSLTSAEDLDIVDGRSISTEPDDRQNTAHPDIIEGSSFEESEQSVEKYLRQTLKPCLELPSVQLLNSHNLTHQHNPNTPTIEITTNMSSSSTSMSKQPVDEILVEPPAAQPPRPDDTLSVHSDHSLHPGSLDASHAKNRKIYIMRHGERVDFTFGTWIPYCFDEFGNYMRKDLNMPKTLPRRKNSPEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGLKLTGKQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPASELTARLKESTEQFYERNHDVILQLLEQTTGNILVVAHATTLDTCSRQLTGGVPRSTNELRQVIHKIPYCSLATVEQVDGVWKLVEPECLPVTHSKNPRFEWNALSAT
The following text describes a protein:
Function:
Involved in the D-alanylation of lipoteichoic acid (LTA). Could be responsible for the transfer of DltC-carried D-alanyl groups to cell membrane phosphatidylglycerol (PG), or alternatively of D-alanine residues from D-Ala-undecaprenol phosphate to the poly(glycerophosphate) chains of LTA. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein; Extracellular side.
Sequence:
MKLKPFLPILISGAVFIVFLLLPASWFTGLVNEKTVEDNRTSLTDQVLKGTLIQDKLYESNKYYPIYGSSELGKDDPFNPAIALNKHNANKKAFLLGAGGSTDLINAVELASQYDKLKGKKLTFIISPQWFTNHGLTNQNFDARMSQTQINQMFQQKNMSTELKRRYAQRLLQFPHVHNKEYLKSYAKNPKETKDSYISGFKENQLIKIEAIKSLFAMDKSPLEHVKPATKPDASWDEMKQKAVEIGKADTTSNKFGIRDQYWKLIQESKRKVRRDYEFNVNSPEFQDLELLVKTMRAAGADVQYVSIPSNGVWYDHIGIDKERRQAVYKKIHSTVVDNGGKIYDMTDKDYEKYVISDAVHIGWKGWVYMDEQIAKHMKGEPQPEVDKPKN
The following text describes a protein:
Function:
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Subcellular Localization:
Cytoplasm.
Domain:
Substrate binds in a cavity formed at the dimer interface.
Sequence:
MLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALK
The following text describes a protein:
Function:
May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
Subcellular Localization:
Nucleus.
Sequence:
MAAAGARPVELGFAESAPAWRLRSEQFPSKVGGRPAWLGAAGLPGPQALACELCGRPLSFLLQVYAPLPGRPDAFHRCIFLFCCREQPCCAGLRVFRNQLPRKNDFYSYEPPSENPPPETGESVCLQLKSGAHLCRVCGCLGPKTCSRCHKAYYCSKEHQTLDWRLGHKQACAQPDHLDHIIPDHNFLFPEFEIVIETEDEIMPEVVEKEDYSEIIGSMGEALEEELDSMAKHESREDKIFQKFKTQIALEPEQILRYGRGIAPIWISGENIPQEKDIPDCPCGAKRILEFQVMPQLLNYLKADRLGKSIDWGILAVFTCAESCSLGTGYTEEFVWKQDVTDTP
The following text describes a protein:
Function:
Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity).
Sequence:
MIYLKILEKLNQAIWLFDINKRVLIWGNQSCKKYKNIESITSLFNNSNLINDIRNGKSKHEHIDIIESNENGEILKQMIFKYSSIHISDMDARQLYLDTSINLLVNQDSHYLDYEGKRIFILVEAIEEIKFIQSPLSSSIENHNINNNQNNQNSVNINSSNKGQYNRPEPSNMGSWEWNVQNDTTKASNQFYKIIGIENDFNKKLNFNDFINKLGIQEIQPIINNCIESNSSSFEYPLRINRKNDNLVRYIQLKGEIIKKDDKVFKVLGVCHDFSEIQEAKDKLEEESKFVEALIGCLKAGIVACNSNGDLTHFNKSAQDLHGLELNDKTDRKQLLDQILKCYRSPYEQINLEKSGTPIIRALSGEFINDQEIIITPTSNQQQSSLSKSNRPRSQSNCSNGNKSQNRLSKNYSTTTTTTNNNNNNNNNNNNNNNNNNNNNSISQQQQTQVSTQQTQQQQNTTNGIGGATTSTTAAAATITSPQQIPIATKIPTKINDNEFLVLASGQEIVSKDGKTIGAFVALHDITERKRNEVILKNATEEAQRANQLKGEFLANISHELLSPMNSIIGMVGLCLDVAPRNLKEMLNDVVESSKILLDLLHQILDFTTLESNSLAVRPFPFKLRDTFNQLFKVFYTRIIEKKISLTFSIDPNIADDFYGDQNRLKQILSNLIDNAIKFSNSSNINNSISIIVEQLTHNQFKKYKDSFRSNSKTHSRLNSHDDYSIDGDYDDQDNNDSYFGRDINVSDNESAVGGFSELDEKDNSDDDDENDDENDETDENDDDTDDDTSSNTSRNNISNNLLFHNNTSGGGGGGINKREKFKKKDREGFVNLKFSIKDRGIGVPEDKHDFIFDRFFQVDGSYSRVQGGVGLGLSICKKLIEFFGGAIWFESEASQGSTFHFILSIKSVEAPSPKSPSLQSSNGSINSTTKLFESSRLKNEIYIPSLPNVQTKKVKKDSNDNGNNDSTNYGISLSNSMNNININGSTLNNNNSINNNNNSNDNGPLTSRTPSNSYYNFIASLNNTSLKSSSHNTLSSSPTGFNGISNLNISGLNNLSNLSNNPNNLNNIIGNTNGNNNTNGNNNSGISLNNSNNNIQTPNGLNNSRGSSLISTPSTKNVKKQHSCPMDLIQRIHSICTPRGPISKECGLNNLPAYSPPKSPGRSLSHGGKNYSNLISTPRGGVGYSSPPINSSSSSGGGSSTNGSNSGNSSANNSTPSSSSLSSTPLTSSNTPSPVSISSNNVNNNNQQQQTQPILSPILPLKDNSIDISDLNNINSLTPNSSNSTSTNVTQSSSNIINNGNSITIINNNPVTPNGKKIVIVPLLSLQSASSPKQSQRGYSPKQQYSPKQYSPKQQYSPKQYSPKQQQQQQQQQQQLEQLSGRMSPHKSNLSSTNLHHIHHHHIHQQQSQQHNNTTVHSNNLILNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTNTSNNHTSDPSKSSNSTPETSPPISSPRSNNNNNCSLTTIVGVTTPPQPSSTITTPQFQSPPILSGNSGNINLLSSNGTSSGGIEISGSQMIPQKVLVAEDNTMNQKLIKTLLTKRGFDITIAKDGKQALDFYHESKNKSILYDCILMDIQMPILSGLEATCAIREIEANEGGHIPIIAVTAHAMKGDKEKFLESGVDDYVTKPINPKLLYEVINTQICKYIEENRSSSTINENKNTINNNNNNTNNNNNNNNSSNPVNNNNSNSIDATQQELNNEKIRI
The following text describes a protein:
Function:
Secreted cytokine-like protein (By similarity). Binds to the scavenger receptor MARCO (By similarity). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (By similarity). Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Miscellaneous:
MISCELLANEOUS: [Isoform A]: Major isoform.
Subcellular Localization:
Secreted.
Sequence:
MKLVSIFLLVTIGICGYSATALLINRLPVVDKLPVPLDDIIPSFDPLKMLLKTLGISVEHLVTGLKKCVDELGPEASEAVKKLLEALSHLV
The following text describes a protein:
Function:
Transcriptional activator that initiates multicellular development by induction of adenylyl cyclase expression.
Subcellular Localization:
Nucleus.
Sequence:
MTAIFPNSNIPFYYWASTNAQPQQPQQSIQQQQQQQQQQQQQQQQQQQQQQHHHHQNIPPTPQPIFSPQLINKNFGCYGTSNQIPMIPQALFPQQTFNYSGLPLCPSPPNYNNYHTITNSPPHQIHSPQLTIDQHSPPTCVSGELSPTPLSSSTGFSNNNNNNNNNNNNNNNSNSNNNINNNNNNNIKRSYSAMMEENNYPNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNINSSGSISSYSNNSCIEDDYSSDKHCSDKESSNDCDDDADSYFEEYEDDQEAIRVSITPFVNLICKTPGITIPIIKIFSECSKEEITVKQMLLKVSLFLKIIIKIKIKIKIKILIFYFLFFKKIKNLCLEFNLDNSIHNTLIHSLVKIDGDIKMVKYLIDNGISEQELEFTKDILLTSNSQEIIKKKRERKRESISRGIRSPPNKWTKEESQNLIKLVTENGDKQWKKIATKLGGGKTGAQCAQHWKRVLSPEIKKGSWDEAEEELLFQLVDKHGQSWKNVAIEIKTRTDIQCRYQYFKAIMSRQTEWNQLEDDILTKKIKLMTQNNEKISFQQVSKHLARAKTTKIPRTALECKSRWSQLNSTNVNNNNNNNNNSITTSSSNTNQQQQSTMVTPTSSPLSSPIPMSTPIINNSMPQQQVQQIQQQQISIQPYPQSFIQETQGFYRGNDQMQYHIQNQTIPQYHHQHNNNPLLML
The following text describes a protein:
Function:
May have a role in the cell cycle.
Sequence:
MSHTILLLQPTDNIESRSWSDYENTTECLEGICRVYEEYLKKKVPAQNEITYDISHLFEFIDDLKDLSMLVLDNTTYTYVPHNKQYVKESIYKLMNNRLNNQH
The following text describes a protein:
Function:
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
Sequence:
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRLTPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTSTGKLQRNKLYRG
The following text describes a protein:
Function:
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Sequence:
MSFKLFRRGSARCIGLLSAFVTILLCLYYISIGQPNPTPISETGAPSAALRGSPLSGLTGFSVDGGSSSIIHQQKQQLVIASNQKKSSETKSAQTSVSPEEQSEEQYTNSNWGDKCYELIQSNTNITASEEHSKFDFQPEWMRSKEYWDRGFEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAGSLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQLLLEQYARTASLFPHNVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEAIKERMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAYNTARQAKRENAIKIYEKNYELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHGFLLSEFERDNFNKLPRKMPIQMANGDESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKRLEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTVGRIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAYRSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQDSRLRLTLLTTHAQGAASYEPGQLEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVEDLPGGQHVTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLEQPELAAALLPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDCSVSAGRELSMEAICPLSSKGLGNVQLGRLSLHTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNLTFRSEV
The following text describes a protein:
Function:
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Miscellaneous:
MISCELLANEOUS: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEPVQYSYEDFARLPTTVFWIMGYDMLGVPKTRSRRILYWIYRFLCLASHGVCVGVMVFRMVEAKTIDNVSLIMRYATLVTYIINSDTKFATVLQRSAIQSLNSKLAELYPKTTLDRIYHRVNDHYWTKSFVYLVIIYIGSSIMVVIGPIITSIIAYFTHNVFTYMHCYPYFLYDPEKDPVWIYISIYALEWLHSTQMVISNIGADIWLLYFQVQINLHFRGIIRSLADHKPSVKHDQEDRKFIAKIVDKQVHLVSLQNDLNGIFGKSLLLSLLTTAAVICTVAVYTLIQGPTLEGFTYVIFIGTSVMQVYLVCYYGQQVLDLSGEVAHAVYNHDFHDASIAYKRYLLIIIIRAQQPVELNAMGYLSISLDTFKQLMSVSYRVITMLMQMIQ
The following text describes a protein:
Function:
Probable transcription factor.
Subcellular Localization:
Nucleus.
Sequence:
MAALGRAGETMSMTATGLSSFGGQNLMRMMNDMGISNSLVAMLTSCNPHAGFRVSSSGGGLEEEATGRGQKRPHYPISDKGPGEEPEEGDDCCYDGAHPMEKKRRLSFEQVRSLERNFEMEIKLEPDRKMKLAKELGLQPRQIAVWFQNRRARWKTKQLERDFELLNSGYSKLKRDFEKVLEEKDVLKAELVRLSAKIIPKDSQSVDFSQSEKDSHCKPTANDPAKSDKLKESKPATPKDNQSTRSSPTTVVCSATTLEAEITSTSSGSNSSDLLDADSPRTTDSNPREEQLANYCGQLLPENFVGHLTVEEAVNTSQKVYSVKLEDGCHHFQVDATSGYFLPPMAEQSILPWWDWP
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MAAFCGAVQLQPPPPCRQQHGASLRLQIPAAPRAAGGCTVNRGSELRPDPAAGSFLSPRRARRRRRGPAAIWRKLGKLQTSTGRWRERTTAAPLHPESLRPPRVPSGPWGNHVCGGGSPACPHPEPAALPRLNEVPRAGHELGSAGAEIPSDPCTGYRFFKPGGLFGIKQSEEPFPEGQQMQEDSKILVSPCAVEPVRANKVEQPDEKPGVAAGSLELYPTGASSSGRWFHGGQRAPERAGTERDGAAGLSPVPSRVGCWVPQLGTGPFRCAQCGKGFRQKQSLITHERIHTGEKPYRCGDCGKSFSQRPNLLTHRRVHTGERPFPCTQCGKSFSQKANLLAHQRIHAANEKALAGGEQDDGGSGKPKLRATQRSYQDDTPFVCPECGKSFRQKPNLITHRRIHTGERPFTCFLCGRSFNQKTNLVTHYRVHTGERPFACTQCGKRFTQKTNLVTHQSTHTDVRPYPCGQCQKCFKDKVSLKAHQKTHAPRQRRCPGRGPAPTLPFGAAPTLLQPGSLEQEAPFSSMPPLPVQKLPEGQELYSCTEKGFPSKEQLLPTQQAPLGEQAFPCVQCGEGFCPKVTLLRPQHGPTAEAPAGCTAGFSPGPHLLGHLGVQPVLGDGTAPAPPTPGAEKPFICNQCGNSFGLWISLVAHQKTHVGQKSYQCPEHDKSSGDELSTKSPQEKDMEGRAWLCPECGRSFVQYERLVKHRQNHRGRGPYRCDVCGKRFSLKTNLVTHQRIHTGERPFTCGVCGRRFNQKGNLVTHYRTHTGERPFACTQCGKRFAQKPNLIAHQKTHSGRQPFTCLECPKRFKSKLSLRVHQRVHVVERPQSEPGPGQTPPSLQSHPGSPYPCSLCGESFEEHGELQLHRQGHTGERPHACAECGKRFRQKVNLAVHQRTHTGERPFHCAECGKGFSQKAHLLRHRRTHTGGVPPSCCEGTCPAHREEPDAGTALGKGPAPPGTLLPPCSRGAVQGPLPREELRPAAQPGPNRAESPSGAADILLQLMQEEQHLVSGSQHPQEAPAGQCPCKCSEGGEGLGGKPTLQPQCCCADCVTQRQLLLKPQHDCRAEIWCKYGGCGRSFEDKRVLRVPERAHSEEKTSPCPSCL
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MSDWENDDEPQQPVAPPKLSAAGRKKFDDEDVEDEVKDDWEEEDSEPEAAKTPVVLPPRKKKSVKQKIAEKEEEERLRREQGLDTDEEEEEEEDWDADPIAKRRMEREAQLKSDVENAANLLGTAKLSDDELSSLKTANPSSKEDWEKLSTSIFTELIKKHASKPGFEKHFVPHFYKTLASTMRDVDIRKASTMLKTYAEEKVKAEKEAKKAGGQKTKLAAAKPKMVGTSSAKNVIDTNVYGDEALDDDLDFM
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MSSVGISSIYSGCSVAAGVTGNIFAFVLFVSPIPTFRRILRNKSTEQFSGLPYICSLLNCLITLWYGMPLVSPGIILVATVNSVGAVFQLIYVSIFISYAEKAIKLKISGLLIAVFLVFLAIVFTSMEVFDSNGRRLFVGYLSVASLISMFASPLFIIVSSSGTQAFRLLRLHISLHSYGCMYIFMQKLVIKTRSVEFMPFYLSLSNFLMSLSFLAYGMFKDDPFIYVPNGIGTLLGIAQVMLYSYYSTKSGEVSRQPLIDSFA
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MHIIISKISCRQLSSVVSPKPFYEHEDDEDENHTDDQGDGDQIQWIRQAPRMDNYSKYDNFSQYSSPSFGERRYGEEESLLQLLKKDLDTKPNCNVPHGQPHSRDNQSRLPEDHGEESLLGLLNGGQVEIDRGGQPRHAGREEESLLDLLNNETGMDYKPSSNFTENGENGIHRGSQPTDDSGDESLFRLLNGVATNENAPFTYPTTNGQHDTLQYPQPYEAEEHKEESLVGLLNEEFTRHSTDKYKELRRLQLQLEIESTEEAVMKCLSTWNSARDRSDHTTIPAIRKVVTSWYGSLTEAIELEQWLYLNGDNKTSSSSQLDTQSGEDGGESTNSNGLQKTDVARDRTIYGPLLCLLPPQKTAILLAHTALSCSVAGGELGSKVVSLAIYIAQALETEVNVSRALRVRASQRKWKMNNLEDEGDEVDGVVQMSTKPPNGSDSLSDNITVDKWVYTATHLKRFLDELSGNGATSGDQKPLKGQGRLRPALVRKRCQDILLAEGFMGEGDDDGTTAPKRPISLTDFAEWDPVLKVKLGAALIRLLLEHTSFSKRRGSSPEPAFFYSRKKTGEMKFNGFVTIHPELLKIAMKEELSHDSSFISPRYMQNTRCQPMVVPPKDWKAVDDGGYETIKTEFMRTRHCKTQKDAIRHADLTQVFEGLNVLGRIPWKINQNVLDAACKCWDDGIALGDIPSQDNHQVPPLPTPLDYRDFNLLDDDEKKVQVDAFRIYKDAITKHFRFKQKNMDLHSLRCSAMLKLNQAKKFRDFEEIFFPYNVDFRGRAYPVPPHLSIVGSDLCRALLMFAHPKPLGPNGLYWLKVHLANLAGANKMSFDGRAQFADDNMESIRAAVDNPFGGNDWWMGFDDPFQGLATCHEIVKAIDSGDPANYMCSLPVHMDGSCNGLQHYAALGRDKVGGKAVNLCIADEPQDVYIGVMHEVIRRVAEDAQEMLPFDETKADLTKAEKELMKKIKSARLVNGLIDRGVVKRTVMTSVYGVTYIGARNQISEKIEEKLEDKGYDIDEMEAEINMACGYLASLTMEVMGQLFTGARQTMNWLTACARLIAQQGQPVAFVSPVGVPVVQPYRQKRPFTVVTLLQNVVLSNDSDVLPLHRQRQVSAFPPNYVHSLDSSHMLLTAIEMQKRGLHFSAVHDSYWTHPCDVEEMNDILRECFIDLYSQPLLEDLKDSWELRYPSITFPDVPTKGELDLNDVKSAPYFFQ
The following text describes a protein:
Function:
May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells.
Subcellular Localization:
Nucleus membrane; Multi-pass membrane protein.
Sequence:
MVQSTVTVNGVKVASTHPQSAHISIHIHQKSALEQLLGAVGSLKKFLSWPQARIHYGQLSLGVTQILLGLVSCALGVCLYFGPWTELCAFGCAFWSGSVAILAGVGTIVHEKRQGKLSGQVSCLLLLACIATAAAATVLGVNSLIRQTSVPYYVEIFSTCNPLQSSMDPGYGTVRYSDDSDWKTERCREYLNMMMNLFLAFCIMLTVVCILEIVVSVASLGLSLRSMYGRSSQALNEEESERKLLDGHPAPASPAKEKIPAIL
The following text describes a protein:
Function:
Component of a deubiquitination module (DUB module) that specifically deubiquinates monoubiquinated histone H2B (H2Bub). Does not seem to be a component of the TREX-2 complex. Seems to act independently of the SAGA multiprotein complex. The DUB module is responsible for the major H2Bub deubiquitinase activity in Arabidopsis.
Subcellular Localization:
Nucleus, nucleoplasm. Note=Displays a rather patchy distribution forming a punctuated pattern in the euchromatin. Does not localize in the heterochromatic chromocenters or nucleolus.
Sequence:
MSGAEDNKSSHAQLSSQIFLDLVDSVIADVASECHRVARLGLDRDLDIVEEELRLSVEARAKIADPSNNLETNTKYVVDIFGQTHPPVASEVFNCMNCGRQIVAGRFAPHLEKCMGKGRKARAKTTRSTTAAQNRNARRSPNPRYSPYPNSASENQLASGSPGVAGEDCSNFTVRENVKGD
The following text describes a protein:
Function:
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs).
Sequence:
MLTPVFWITQDDDALLIRIRAPHGNIAELDYDHGDYMFVFTCPPYFLRLHFKQMVEEYGSGNGSVEWKSDEGEFHIKVPKMHKKEHFSNLDMITELLTPSTTHHQPHGNQLVEEMDDSEDDDEGDGSEFLVEQQPAAEPEEPKSDGKIEKFGYGFGWSKFGVIERLRDEIGKIVDILEPENVEIEKRADKLMEFDWENFDEGRYLADTLEPEEELLAVISSKFAQKLEISDEDRTKLKDLKKSKTSAKINGNDVEIMTSLIDIVFGYCYDQRVNDWESACESGWNCAKLSPSLSFFAKFSSVKECLLACTRRALTYPLYRSFQLTQRVIQDVCHVITAGGGRPALLHILCDLHRIFIESGEFRYILNDLMIADYIFWIQTVPDEILTRIQTDLTEISGKIDKYDIGWDLEVLEAEAKLANTQLDSDDEPDN
The following text describes a protein:
Function:
Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.2, but it cleaves lgg-1 precursors more efficiently than atg-4.2 (Probable). Acts redundantly with atg-4.2 to promote the lgg-1 delipidation to release the protein from membranes, which facilitates multiple events during macroautophagy. Unlike atg-4.2 does not seem to be required for autophagosome maturation.
Subcellular Localization:
Cytoplasm.
Sequence:
MLSILPLAYSNFSRILQYFEQLPVVDKMTEEILKQGVGIVETSLTFEPPFCESFERISIDNFPIFALGKEISKEDGIEAMKKYVTSRFWFTYRRDFSPIGGTGPSTDQGWGCMLRCAQMLLGEVLLRRHIGRHFEWDIEKTSEIYEKILQMFFDEKDALYSIHQIAQMGVTEGKEVSKWFGPNTAAQVMKKLTIFDDWSNIAVHVALDNILVKEDAITMATSYPSEDAVKLIMENGLVDKNRLSLSPGNIIPEWRPLLLMIPLRLGLTTINPCYLSAIQEFFKIPQCVGIIGGRPNHALYFVGMSGSKLFYLDPHYCRPKTESTAKMYAEKDSTATTDDVGFSHLEELVPLPSQTADVYTKMDDSTYHCQMMLWIEYENVDPSLALAMFCETRDEFENLCETLQKTTLPASQPPMFEFLQRRPKYLPKFEPYTGVSMKIEMKEFDDIGAANVKIDDDFEVLDVHTEEEDADEDNDDDVANA
The following text describes a protein:
Function:
Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.
Subcellular Localization:
Lysosome membrane; Single-pass type I membrane protein; Lumenal side.
Sequence:
MAAPALGALLLLGAAAVGGREVSMQYNPGWNGSSVNVLHVRAVGRSDALHYVWSTIGAPSVLLVATRSPDSALSIDWGRLLSPAPTGAVWIDPPGSVVYAAAVVFTKLFEYSNANASEEVFYPTYDLSDFSWDSINRTMNHTALTAELRGVPTSDSSGSFSNGSLAFRVTAYESGGRDGALPGLLHTANSSKVEFVLAGAAPRGNGSRFVLEVATVEERGAASRLRSVRSIDDEYTPTIFERWALRCFCSCWAPPRCSVPGGDPTANTSPSTERRRSARGAIAAAAGNTAPLSPLCLRFWGRAGQGGQWGPPPCRCAALRAAACTDGGASFLPAAHCRGLTGQRVRVIPVIVLILILLLGEGTSCCPASPKAAAMRGNSAAQRSDCFSSGPGRAFRSPRVTAGAAALPRAAMVGGGAAPFPRPQPLTHF
The following text describes a protein:
Function:
Rab GTPase activating protein for the small GTPases rab-6.1 and rab-6.2 (Probable). Probably acts through rab-6.1 and rab-6.2 to play a role in microRNA-mediated gene silencing in different tissue types. Required for seam cell division and alae formation.
Sequence:
MEDFKDFTEVTQFTNVQYLGCSQLVNNDNDNEMKALMKVLDEQKGAQTINVTLVVPHNISGTVKLIDAQGKVLSSFSLVNIRFCIRGESSTSQNNCFGISFTHKISVGEHNSSDILHQCHVFRTSKAETAAKALYSFSYAFSNKNVSSESNRLEFQFESILEVKENDGTVEKPSWKLCPQHNGVFKVRRDREKKIVVQLRQIDGFLLNIKKCFGMLLAAGRNLRHSDLQLLEMDRNATGTDSAVFVIEANWDPRVHMFEVLNTETPRDTRVFMTVAIDVIVSEISEPIRFSMEAMSRVFHEHERFYKTPQTVVSEEFTLVLEKSCDQSDPNDRKLTFISLESDSDRKRSKQNLGKSPSRMPTQLLHPTGDDESDCDEPLLSGSGKVSQECKEEHLEMWDQLIENWDQQSDRPQKISELVLDGIPDKLRGRVWQLLSNVRILAIDQPDLVEKYHIFLSQPCPSEQVIMRDIHRTFPAHDYFKESQGKGQQSLYKISKVYSLYDEEVSYCQGLSFLAASLLLHMPEEQAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTALLKDYIPDLSHHLEHIGIETHMYASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQLDFEGTLKYFRVSLPRKYRTEASTKCLIHKAVKFRLNHSKLEVYENEYKRIKELERENEDPVLRMEKEIGRHQANTLRLERENDDLAHELVTSKIELRRKLDVAEDQIETSANAIERLTRQNMDILEENKNLMREYEQIKEMYRRDVLRLEENGSRAEKLLAEYKKLFSERSKRAENEREHFEVQKKAIIARISDCDKCWPAVCEWEKNRSPVHSASTPTGPDLLTKLEEREDHIKNLEIDLAQTKLSLVEAECRNQDLTHQLMAQSESDGKKWFKKTITQLKEVGSSLKHHERSNSSVTP
The following text describes a protein:
Function:
Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular Localization:
Nucleus.
Sequence:
MQLERREDSPAGENGTEFTLRWHHHDVKLADTMTRAWEKKLFLDVTLASGHRTLGAHRLVLCACSALLENLLTSPAHSPVQSHTNPMLYFNDIDFEDLEVLVDFMYRGSMTVTYQTLPGIINAARILQIRGLNPDIDEPVDSPPESSGSSEPPAPEPTGEPIRKRIKKDVVEDVIKSHQEIKDEMGSDHEGFHTPHGVIGPEHANYDEQKQQQLAAFLSVLAQQTPLNQSTKQTTSTSAGPSPALRSRLVWDPAHIVYLESWYGKETRYPSLVQCQAYANQLSRVPQSDQSGKSRTSMSVTAQNVSHWFQNRRRKDTHPEIEEKRVKRSQTRRTKKSNSGNPLDLTQSTAPRMKQSTTPPSLNRSPQEPSHHPDHDDRDSDDEPGLCIAENAHNSYNSDTENDHPSSIHHPHYQL
The following text describes a protein:
Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MGDEYMDDDEDYGFEYEDDSGSEPDVDMENQYYTAKGLRSDGKLDEAIKSFEKVLELEGEKGEWGFKALKQMIKITFGQNRLEKMLEYYRQLLTYIKSAVTKNYSEKSINAILDYISTSRQMDLLQHFYETTLDALKDAKNERLWFKTNTKLGKLFFDLHEFTKLEKIVKQLKVSCKNEQGEEDQRKGTQLLEIYALEIQMYTEQKNNKALKWVYELATQAIHTKSAIPHPLILGTIRECGGKMHLRDGRFLDAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLIKSDINPFDSQEAKPFKNEPEIVAMTQMVQAYQDNDIQAFEQIMAAHQDSIMADPFIREHTEELMNNIRTQVLLRLIRPYTNVRISYLSQKLKVSQKEVIHLLVDAILDDGLEAKINEESGMIEMPKNKKKMMVTSLVVPNAGDQGTTKSDSKPGTSSEPSTTTSVTSSILQGPPATSSCHQELSMDGLRVWAERIDSIQSNIGTRIKF
The following text describes a protein:
Function:
By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP.
Subcellular Localization:
Cytoplasm.
Sequence:
MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLLDFIQKHLNK
The following text describes a protein:
Function:
Important role in the capacity of milk to transport calcium phosphate.
Subcellular Localization:
Secreted.
Sequence:
MNWTQAQSTCQQRGLHLITIQKFNEASAIAPLVKKYQQNENIWITLEKPIQNKQWKFTHRHGNGNGKHKPSNGQEVTIKKEVCVELVAREGFLKWNNLDCEERRSFLCQTLHLHSELLMKESNVTKLSKVTESNDKNKDYKLTKYGGKIREKTTTKEDQKIKENLFTNNHSSEKSSTSLLMMTLALTSMKLLILTCLVAVALARPVSTEENLEQKRIPREDMLYQHTLPFQPSYQLDVYPYAAWFHPAQIMQHVAYSPFHDTAKLIASENSEKTDIIPEWW