lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
Subcellular Localization:
Cell membrane, sarcolemma. Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Postsynaptic cell membrane. Secreted, extracellular space.
Sequence:
MNLRYQETFCIIFLLCTSITLAEDFDFVPEQNDDVEPIAAEPPKVDSQPKLSKAGVRCLPTESTIQLSLILRAKSWKHVQTSLKQRTISKLAEYFLVPEESIIVRDATSNDLHKMVEKALQHGKKPSRTVGKSLGWIGFPVGCGEKMSSSAKETVRNVNTQLAELRDLTGMDFGWWIIWKEQTGGGAASDKRIKREVDPDDDYYDYDDDEAAEDDDEGETTEVPHAHRHHHGSSEPTSTQRSVSTFTTPKQNNEEEDKELEYENYDDEYDDEEEGAIELTTQPDPRVLSSTTTTERPMPSSTEPSTTPTTVTMPTTTPSTTTTTTTTEAPTTTTTTTTSTTTTTTTTTTEASTTTSTMLTTELDEPTNLPPIIRNRIPKQAIPAGKVFRYQVPLETFHDNEDGNNLSLELLDARDQPLKPSSWIQFNEDTKEIYGLPLEKDVSRWPYKLRATDSGNLTVTEKVDIQVQQHKSHRSLNHEISLALRLNRKFASNVDWHIETARGISVVLGDVTLSNIIVRDIRNSIQDPSLATFVYTNETLPKDRCPEEKLDELVALLTEEALNDALNPDITVKSVQGQQIAQCTKVTPPKVKPTQSIQRNYAPQTRNQVDQVNATVGHLLVFKVPVDTFYDPEDGNELKMKLLTTDRNTLDPNHWLQFDSKNQEFYGVPRTNDIGRKEYLLMAEDREGLTATDALVVVVNPHHKRDYSVLFELTLDISHEQFNTAQVQRRFIERLAQVFGDASTHYIKIHHIRPIHHTGQVQVSFFNTTLSRQHQRCPQEEIETLRNILLHQDSTIRAKVREILGQEFSLQNVSLVPLDNCHGFDTPHHATSEPEKAAPKPISKDDYLLTFVLPSVIIIVMLLIAAIIACILYKRRLTGKMELGTDEERKSFRSKGIPVIFQDELDEKPEIGNKSPVILKDEKPPLLPPSYSSTNHDGDNEDVDEYVPPQPVIVGGRESRGKSPVTPSYRRPPPYVSP
The following text describes a protein:
Function:
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.
Subcellular Localization:
Nucleus. Note=DNA replication foci.
Domain:
Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Sequence:
MLEEPEAATRTAAAVDCKDRPGFPVKRLIQARLPFKRLNLVPKEKVEEDTSPKAAVESKVPDLQLSLGTFESQCHTGSHVGLSTKLVGGQGPIDSFLRATIKPVPSVVIIDLTENCSDIPDSPEGHSELSPDTAGVVTTVEGAAKQQEHSAAELCLLETPSDITCHMEEEPGSPGDPKRTGDCQAGSLQSCPELTPGSRTCPTKELSSWSKAGDLLFIEKVPVVVLEDILATKPSIASLPMMSLDRSVTSESEILESCPEDDSILSHSSTNSSSPTSSPEGPSTPPEHRGGRSSPSTPACRVAKNFVKGSTEKGRSKLHRDREQQREEKEKLREEIRRAKEEARKKKEEEKELKEKERREKREKDEKEKAEKQRLKEEKRKERQEALEAKLEEKRKKEEEKRLREEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRCRAALDQDLCDQLDQLLQQQSVASTFLSDLKSRLPLRSGPTRVCGHDTDIMNRDVVIVESSKVDGVSERKKFGRMKLLQFSENHRPAYWGTWNKKTAIIRPRNPWAQDKDLLDYEVDSDDEWEEEEPGESLSHSEGDEDDDVGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVHQKLKAKEWDELLAKGKRFRVLQPVHVGCVWASEAANCTSSDLKLLQQFTACLLDVASPDEPEPGASRREKRDQHILAQLLPLLHGNVNGSKVIIHEFQEQCRRGLLTLPSPTPHLQMPNLEDAVAVPSKARLKRLISENSAYEKRPNFRMCWYVHPEVLKSFGQECLPVPCQWTYITTMPSAPREDSGSASTEGPGQSTPMLLKRKPAATMCITQFMKKRRYDGQVGSGDMDGFQADTEEDEEDDTDCMIIDVPDVGSDVSEAPIPAPTLCK
The following text describes a protein:
Function:
Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming (By similarity).
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localized to kinetochores during metaphase, and to the spindle region.
Sequence:
MSRVVSRTVPGGACVVNKDDFLKSFNDVDKVSVSSLADAKSKFDQVIAILSKSQEDWNKRRTQLQIIRSIVINCEDVIGRDQLLGQLVRLADCLDLSVKDLRSQILREAAITCSFLFEKYGNDVHQIAERCLPTAFSQLAVSTKVMATSGATLTLFLVQYVQTKQIFTCLTTYSTSKDKNQRRQLCVLLEIVIEHWNDKLKKSILPQIMELIKSAISDADPETRAAGRKAFNKLDAIHSEEADKLFASVDANKQKMLRASDAASSSTSVNSERGSAPFRSKLSAGSVGGMRNVPNISSKFLAQRSASAIDTKQVTRMTTSVSRTPNTRPMTTRTLSKVDTSPGGSKFARPTVGTLGPRTTSNLRARGSVPTSQPGSRNGSPPRRPSTTGTLPMEMQRVKSNLGSSSFVSSLTPDQAESLQKAMNTAKESLGQPSRTEDDEFLLPKRKPKTPQKSAVDISRVEAVIRACVSTSANEKRDGIKMLSIIVSEPNLSQIELKNIGQVLNRLLGEATNPVVLESVASFVKAHHSRLSEWLKLGLGKMFAKKGSEMMPIMKKHIVTTINAILSSFDPALQLKATCELMCDPIHLLSPKARVALLEYLTDLLEKHMERGSPFNTKEVKATILKMFSWMSDQRNMQQIVPHGEKVLCGLFALNAADFSALFNDFNPDYREWAYRILQAHGHNQHAPAPESPSPVRDQQVRANISNTAAQIEDFVVARNFELSAEKSPTSRGMLTSGFKRTDAEPLRPLESDMNTQRMDDISINESFDRLKVRILETTGFYAAFKVDFQE
The following text describes a protein:
Function:
Putative receptor for S.meliloti Nod factor signals essential for the establishment of the nitrogen-fixing, root nodule symbiosis with S.meliloti. Involved in the control of root hair curling after S.meliloti infection, probably by modulating the reorganization of the microtubular cytoskeleton in epidermal and cortical cells. Regulates a subset of Nod factor-induced genes.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Vacuole lumen. Note=Removed from the plasma membrane upon the release of rhizobia into the host cytoplasm. Vacuolar localization is observed in cells undergoing breakdown of the receptors.
Sequence:
MNLKNGLLLFILFLDCVFFKVESKCVKGCDVALASYYIIPSIQLRNISNFMQSKIVLTNSFDVIMSYNRDVVFDKSGLISYTRINVPFPCECIGGEFLGHVFEYTTKEGDDYDLIANTYYASLTTVELLKKFNSYDPNHIPVKAKINVTVICSCGNSQISKDYGLFVTYPLRSDDTLAKIATKAGLDEGLIQNFNQDANFSIGSGIVFIPGRDQNGHFFPLYSRTGIAKGSAVGIAMAGIFGLLLFVIYIYAKYFQKKEEEKTKLPQTSRAFSTQDASGSAEYETSGSSGHATGSAAGLTGIMVAKSTEFTYQELAKATNNFSLDNKIGQGGFGAVYYAELRGEKTAIKKMDVQASSEFLCELKVLTHVHHLNLVRLIGYCVEGSLFLVYEHIDNGNLGQYLHGIGTEPLPWSSRVQIALDSARGLEYIHEHTVPVYIHRDVKSANILIDKNLRGKVADFGLTKLIEVGNSTLHTRLVGTFGYMPPEYAQYGDVSPKIDVYAFGVVLYELITAKNAVLKTGESVAESKGLVQLFEEALHRMDPLEGLRKLVDPRLKENYPIDSVLKMAQLGRACTRDNPLLRPSMRSIVVALMTLSSPTEDCDDDSSYENQSLINLLSTR
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MDFTALDVLLSIANVSAAIPTLRKIRSTCFRTTYKMCVFITFTFCLAFTFYNRFFFYVKLSGLKLIIRIFVDIALTLLDYYILIGVYVFKEKWITLIKNLKRLESVPPKKKHPHLITIACTHFANISAIMYNTVLWARILKSTYYKAFSFELMQLHLKFLYNFIIYVILEMMISRYTFVKHLLTNQQKNIQVLKKCTYSVYLLKETVDIFNDLFGWPILFTVMYASLRILYCFESIIRDSAAARIHLILGDVAIILLYLLAVTAIILKCDHVTREAKAILKLCQNLKNTRRNEMLDKFFVITSDVLPTFSAAGFFTIRKSTIFSILSTISTFGIVVLQFKSLIIEMDEFKQRS
The following text describes a protein:
Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular Localization:
Nucleus, nucleolus.
Domain:
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence:
MRKTFQPVVSYNQASFKGPSQRLLELCVVNMKRKLDANDVPSTEVEEEKNTKDADNTDFESLNLDPRLRQALIKEQFTKPTPVQSKAIPLALEGKDILARAKTGSGKTAAYVLPILQTILQKKAADPSLKATTGLILVPTRELAEQVQSVIIKFSAFCGKDVRSVNLTQKVSDAVQRTMLADYPDLIVSTPARVIANLGTSALSLENLTHLVIDEADLVLSYGYDEDINALAKAIPRGVQTFLMSATLTSEVDTLKGLFCRSPVILKLEDKEDEGAGISQFVVRCAEDEKFLLTYVIFKLQLIKGKVIIFVGDIDRCYRLKLFLEQFGIKSCVLNSELPINSRIHVVQEFNKGVYDIIIAADEQEVMGLRTSSKKSKEATDGDDEAKDKMGSSEDEDNEPEQSGKSARPEKRRKTSGKAKDYGISRGIDFQNVACVLNFDLPTTSKSYTHRIGRTGRAGKAGMALSFVVPADKFGKHKPTSFPTAKHDESVLAKIVKKQAKLGHEVKPYHFEMKQVDAFRYRMTDALRAVTRLAIQEARAREIRQELVKSEKLKRHFEENPEELKQLRHDGELRAARIQPHLKHIPDYLMPSKGRKGISSEDVGFVGFRKSGDNRIRKAREKNRGKGKGRKPSGVRKVDPLKTFNRGRK
The following text describes a protein:
Function:
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
Sequence:
MASVTEHAQWGVGCLPPLNVDKQAIAAAFSRAAESYDSAANLQRETGHRLVQLGQQHTGFVVLDAGCGTGHFSQHWRLLGKRVIALDLAAGMLDYARQQQVADDYLLGDIEHIPLPDQSVDICFSNLAVQWCSDLGAALSEFYRVTRPGGIILFSTLAEGSLDELGQAWQQVDGQRHVNDFLPLQHIQTACQYYRHHLTTALYQPRFPNVIALMRSLQGIGATHLHHGRQAGLQGRQRLAALQRAYVMQSGGYPLSYHMVYGVIYRD
The following text describes a protein:
Function:
Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism (By similarity). Also involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family.
Subcellular Localization:
Secreted, extracellular space, apoplast.
Sequence:
MGGEKAFSFIFLLFLCFFLANLSASSAHPPRQKLKQRIPCKQLVLYFHDVVYNGHNKANATASIVGAPQGADLVKLAGENHFGNVVVFDDPITLDNNFHSPPVGRAQGLYVYDKKDTFHSWLSFSFTLNTTMHQGTLIFMGADPILIKNRDITVVGGTGDFFMARGIATIATDSYEGEVYFRLKVDIKLYECW
The following text describes a protein:
Function:
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MGKVKVGKARRDKFYQLAKETGYRSRASFKLLQLNRKFEFLQKSSICIDLCAAPGGWLQVAQQYMPVSSLIIECVLIEFFLLSGVDLVAIKPINGVITLKEDITTDKCRQSLRKLLPDQKADLVLHDGAPNVGKNWVHDAYQQAELTLKALHLATFFLVKGGYFITKVFRSKDYFSLLWVLQQMFKKVHATKPLASRNESAEIFVVCQGYLAPDVIDPKFLDSKHVFKDVEQENSVRPTLNLVHPDKISKKAEGYDENNYLQMHKLSAVKFITDANFLELFKHCTEIVLDDESIISHPSTTDEIKECCKDIQVLGKKDLKNLLSWRKCLNKSLPQLNIMANDNEKMDVENDQEETIEGVEMENDEANKDADSDNDSIEEVIEQEEKELSERRARLLKDKKKKHKKVMNEKRKLREKMALQMVIPGDSIQATDDIDLFSFNSVKKDAGIAFKCDDVEPDDDDDDDDEDDAPEPARRIKFDKEDVALYDDEGEAWNKLNRHDSDDDEEEDKVEGDHKASSNNKKRKIVKLNPLELAIGEEIVKSKKRRRELVELSYNRYAYGEDSAPDWFLHDEMKHSKKQLPVTKEQIQYYKEKQKAIDANPIKKIAEARARQKHKLVKRLEKARKRTENIGEDLPEKEKMKQAKEIYKKAGLLKAQKKKDVTYVVAKRGVGKRVSRPAGVKGHFKVVDPRMKKDNRKMKHESKSKGRKSSAGKQKSNKKAGKGRKKR
The following text describes a protein:
Function:
May mediate microtubule plus end-directed vesicle transport.
Subcellular Localization:
Cytoplasmic vesicle, autophagosome. Endosome. Lysosome.
Sequence:
MEAAPGESQLQRIIRDLQDAVAELSKEFKEGGEPITDDSVNLQKFSYKLEYLLQFDQKEKSTLLGNRKDYWDYFCDCLAKVKGANDGIRFVKSITELRTSLGKGRAFLRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLNPKMSSDIVGQLYELTDVQFDLASRGYDLDAAWPAFARRTLSSLGSSAYLWKPPSRSSSMSSLVSNYLQAPEFPSSPDANNSLNAEHFEGFEEMRVELDQAELRQKELQRSIHQLEMENQELQAAVSLQKEQLQLEKEKSNNYSEENSRLTKMITELQKQCEVSHSTQSTVHDLQKCLQSLELNAVEQQKEYSTKLAQLATSKEDYASKLQLLNEELEVSRALVAMKELCIDELKAKLSSTEQKNLNLLAKVDAALEEKGHQAMAQCDSALQIQALLEKLQQTEKEKAEMQRLSDECTSQLKTAEEQLRLKEEAQKELESRYNCLTADSREGSEKLLRSLETMEKEVDALQKALTLKEKKMAELQTQVMESLAQVGSLEKDLEEARKEKEKLKEEYGKMEEALKEEAQSQAEKFEQQEGHLKKVSETVCSLEEQKRKLLYEKEHLSQKVKELEEQMRQQNSTVNEMSEESRKLKTENVDLQQSKKKVEEKLKNLEASKDSLEAEVARLRASEKQLQSEIDDALVSVDEKEKKLRSQNKQLDEDLQNARRQSQILEEKLEALQSDYRELKEREETTRESYASLEGQLKGAKQHSLQVEKSLDTLKESKESLQSQLAEKEIQLQGMECQCEQLRKEAERHRKKAETLEVEKLSAENTCLQQTKLIESLTSEKESMEKHQLQQAASLEKDAKELASRLTVSEEQLQVNRDEVSRLQTEVLDLRVKLQQTTDEREQLKSELAITETVLGEQKMLVQQLKEQTESLNRNHVQELVQCKEREEVLKREQEAVVLQKTELENNLLSLKEELSKFKQYLEAARMENVENKDLLHRTNTDMAELGIQICALSSEKVDAEEQLAQAKERLKELEEQAAMQQEKLKHDISNLRQENRSLQEKLEEAQICVSAVPSLQAQLETAKKQAQSFQETSQEELSAIKFQMSTEILNYQTKFKTASEECGKLRDQLEEQKRQQHATEEEIAGLQAENTSLSRKLDEAREQLSELQSARLQKEEEVTSLRELLERTQKEADEAKNQALDYSEKLSKMAADKDSNDQKLFAELDDLTRTKQFLEERLIELIRDKDALWQKSDALEFQQKLSAEQKWQGDTEVNHCLDCQREFSWMVRRHHCRMCGRIFCYYCCNNYMVTKPGGRKERCCKACFNKPRVIVDNTDDSGSSANQEGSPGSLESPVSPVAGEVSKPPDDAAFDIITDEELCQVQESDSLHSESQMDRDSLDQSVTDLPVIHSSWYSRVYPVHLPFWRNSTCNSSTFDESEEWQVAQDAEISLLKSGEIMVKLPLTVEEIMNFGEGNRELFIKSSTYSIIPITVTEIGLTISWIFSSDPKSISFSVVYQESEDTPLDQCKVLIPMTRCNSHKETIRGQMKVRNSGIYTLIFDNTFSRFISKRVFYQLTVERPVIYDGSDFP
The following text describes a protein:
Function:
Acts as a magnesium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MPVQVSDSLQVEHRLDQLSQALNSGMFVHVRQMLQNMASSDIALILESSPPKARQVLWQLIDQDQLGDILDELSEELKDPLIRAMSPERVAKATASMDTDDLAYILRSLPDTVYKQVLQSMSLQNRQRVEQALSYPDETAGSLMNTDTVTLRPDVNIDVVLRYLRQRGNLPDTTDTLYVVDKQDKVLGGVKLADLLTCDPNTPISSIIDTDIESIPVGMSDSEVAQLFERHDWVSAPVVDSEGKLLGRITIDDVVDVIREDAEHSMMGMAGMDDDEDTFAPVVKSTLRRSLWLTINLFAALLAASVSNMFEGTIEQFATIAILMTIVPSMGGVAGNQTLALVIRGIALGHIGQSNARWLIGKELAIGFLNGLMWSILVFIAVLVWKDDIALASLIGGAMLINMTVAGLAGASIPLILKRLKVDPALAGGMVLTTVTDVIGLFAFLGLATLYLMH
The following text describes a protein:
Function:
Controls stomatal patterning.
Subcellular Localization:
Secreted.
Sequence:
MLIVDKLQCLHALCSHMLSSFTVLREKEGALLRAASNLPQQHNHKSPPSAQKKTISKDGDCSNGKVKAYSCCVAATVVSLQCHGCRMQGRGGEKATVRALVGSRPPICERRCITCGHCEAVQVPVIPQEKKSRSRQFLGTATVRGDYSSNYKPLSWKCKCGDLIFDP
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs.
Sequence:
MAVSSLQYTMGISSGFKVYILEGQHNSRDTERLRPLNNHGIPVYPIKRKLSPDPPQISKRMCPVSPPSRVKVTLPPMNLKAQAGAPPLKNCGPHLTLEHVLRRLMPAQRHLERSEPATSPEEQPLALVKRVEKPSETAQLSPALLQQMRPSVITCVSRQKPLVPLPTEAANLSRACATKGLCKTPLLDVEEHFQRSLAHKCPMVSRPTPTSPFSSISVEDHFSKTLGSKWPLIRAAADSPSSTEGQSRRRV
The following text describes a protein:
Function:
May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity. Not essential for the accumulation of ER body components, including PYK10.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Located in ER bodies.
Sequence:
MEKSNQPVHVTLSELKDGDKEIVDAEFLVDLLESYRFGKDNVPAREFRSKAAATAPAPVNTTEIELEEDNDGSQAQGNNSVSESTSSLFSDSDPIVLESTVSETGSNEESETGSNEENGNNWLESSSTNLPNVENKRQRNGEDCEIEEEEENNERSLSDSEEKSNLEKLLGTQENYELGNEDEEKNERSSSDSEEKSNLENLLATQENYELYCPSCSTCITRNVVLKKRKRGKHVNSSLDLKPDIPVVEPDEPSDIEEMESPVKVYVPETRIEDDQEDKEGTIFTCLVCDLKYFIRLGTKFLQLDYIRGKPVEKSVEEYIDVRKSINTTQSPPQIQPDGERFAIELLKSTVYGGLTETITSLGVVSSASASGSSTMNILALAVANLAGGLIVLAQNFQDLRNSSDQEKDRYEELLGRRTKSRIHILVAVMSYIFFGLIPPLVYAFSFYETGIKNYKLISVFLGSLVCVILLGSIKVYVRKPTNSCGSTKAYLKSAAYYTSIVVASCGISYVVGDIMGEYIEKLSLVGLDQISITSPCYGIKPEECRFTSF
The following text describes a protein:
Function:
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
Sequence:
MTKSELIEILARRQAHLKSDDVDLAVKSLLEMMGQALSDGDRIEIRGFGSFSLHYRPPRLGRNPKTGESVALPGKHVPHFKPGKELRERVSSVVPVDMVDAAD
The following text describes a protein:
Function:
Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (By similarity). The symporter activity is electrogenic (By similarity). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell membrane; Multi-pass membrane protein. Synapse, synaptosome.
Sequence:
MPFNAFDTFKEKILKPGKEGVKNAVGDSLGILQRKLDGTNEEGDAIELSEEGRPVQTSRARAPVCDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCEVQKTDRRQQRESAFEGEEPLSYQNEEDFSETS
The following text describes a protein:
Function:
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate. Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton.
Subcellular Localization:
Cell membrane; Peripheral membrane protein. Note=Forms dynamic oligomeric patches at the cell membrane. Localization to the cell membrane is dependent on its ability to bind substrate.
Sequence:
MSVLRSQPPSVVPLHLTTSTSRKTEQEPSLLHSAIIERHQDRSVPNSNSNPDSNHRIKKDRNNHTSYHSSSNSESNMESPRLSDGESSTPTSIEELNPTINNSRLVKRNYSISIDPLHDNSNNNTDDDHPNTITSPRPNSTSNKEMQKYSFPEGKESKKITTPSLNSNNCLDLDNSSLVHTDSYIQDLNDDHILLNKRVSRRSSRISAVTATSTTIKQRRNTQDSNLPNIPFHASKHSQILPMDDSDVIKLANGDTSMKPNSATKISHSMTSLPLHPLPQPSQKSKQYHMISKSTTSLPPENDHYYQHSRGTNHNHAANAAAVNNNTTTTTAATGLKRSESATAEIKKMRQSLLHKREMKRKRKTFLVDDDRVLIGNKVSEGHVNFIIAYNMLTGIRVAVSRCSGIMKPLTPADFRFTKKLAFDYHGNELTPSSQYAFKFKDYCPEVFRELRALFGLDPADYLVSLTSKYILSELNSPGKSGSFFYYSRDYKYIIKTIHHSEHIHLRKHIQEYYNHVRDNPNTLICQFYGLHRVKMPISFQNKIKHRKIYFLVMNNLFPPHLDIHITYDLKGSTWGRFTNLDKERLAKDRSYRPVMKDLNWLEEGQKIKFGPLKKKTFLTQLKKDVELLAKLNTMDYSLLIGIHDINKAKEDDLQLADTASIEEQPQTQGPIRTGTGTVVRHFFREFEGGIRASDQFNNDVDLIYYVGIIDFLTNYSVMKKLETFWRSLRHDTKLVSAIPPRDYANRFYEFIEDSVDPLPQKKTQSSYRDDPNQKNYKD
The following text describes a protein:
Function:
Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Involved in male fertility.
Subcellular Localization:
Nucleus. Note=Excluded from the nucleoli.
Sequence:
METLLEQQRRLHEERERLVKLMVDEHATKKPGEKERIHSEHRLKYLMELHHNSTSQLRDLYEDKDNERKAEIAALSGPNEFNEFYARLKQIKQFYKSHPAEVSVPLSVEFDEMIRVYNNPDDMSALVEFTDEEGGGRYLDLNECYELYLNLRSVEKLDYITYLMSFDHVFDIPRERKNREYRIYIETLNDYLHHFILRIQPLLDLEGELLKVELDFQRQWLMGTFPGFSIKETESALANTGAHLDLSAFSSWEELASLGLDRLKSALVALGLKCGGTLEERAQRLFSTKGKSTLDPALMAKKPSAKTASAQSREHERHKEIAQLEALLYKYADLLSEQRAATKENVQRKQARTGGERDDSDVEASESDNEDDPDADDVPYNPKNLPLGWDGKPIPYWLYKLHGLNISYNCEICGNFTYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAITLWEKLKSQKQSERWVADQEEEFEDSLGNVVNRKTFEDLKRQGLL
The following text describes a protein:
Function:
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape.
Sequence:
MEKPSSGANHVAKATVSLSIASVLILGAVLTMLSIQLDEAHERLQNRMGSFKFVARNIWHDIVLVKSNGRIKRQYGGYGSDSAQSDNQQCTSCVQLRCPPGPIGPPGVSGEPGMDGANGRPGKPGLDGLDVPLDPEPAFPCVICPAGPPGTRGPQGEVGRPGQTGESGHPGLPGRPGKPGRVGDAGPQGEPGEQGEPGIKGPPGDDSIGGTGIKGPPGPPGPRGPKGPPGSNGLPSQNSGPPGPIGEMGPPGPPGPRGEPGPPGPFGPPGDSGEPGGHCPSSCGVQEIVAPSVSELDTNDEPEKPARGGYSGGGYGKK
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MEKNSEMIGVKREEEIELELGLSIGGGFQRSERQNPSHAMTKNEPPGSDLRESHHNNSDRLQVESKREFEALRRLEAKRKRLEKQQKKITISCNNINSSGYGVGLDNKMWLKSPELETKEQQRECKKSRAEDEEEGERGPRSNMEMKNVNLNLTVEQNVGFNSTVCPVMYPYPPLQYVQFANGFQYPCLNVVPCWPAGGEGVGNYQVQSVVNRSFRPFQSGQESGRNMGNGCASDQNSWKAGSNGSPGSSAVSDYRSSSHEGGGSSDTRSHSSHSPPEQLKLQNSKADDTKGQSEHSTSPHRKTAQVYDEMTNCPSNSGKPKTSSKDAQCSPPTNCTTNFVQQTALSNAVDCSPAKPKEEVATELHGASSQNPVSTTENLSPTGSKESKKDVGKPPKPQTQSQNTPSLPHMPCVSTTGNGPNGKTINGFLYRYTKTEVSIVCVCHGTSFSPAEFVLHAGGTDVSQPLKHITVIPSAI
The following text describes a protein:
Function:
Involved in metal homeostasis and more specially in manganese sensitivity.
Miscellaneous:
MISCELLANEOUS: Present with 2270 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole membrane; Multi-pass membrane protein.
Sequence:
MSFLPLRSRSRSGAPHWVYIILYHIFTIPKIYSLPLLSGSHVLNSRDVADSGHSVGDEASVTTYYIISIILVLLGGVFAGLTLGLMGQDEVYLKVISTSGSNSEKKLAKRVLDLISRGKHWVLVTLLLSNVITNETLPIVLDRCLGGGWQAVVSSTILIVIFGEIIPQSVCVKYGLQVGAFFCPFVLVLMYLMYPVAYPIATLLDYMLGEDHGTMYKKSGLKTLVTLHRTMGVERLTKDEVTIISAVLDLKAKRVEEIMTPIENVFTMSADTILDDKTVEKIFNSGFSRIPIFLPNEPNNFIGMLLVRVLISYDPDDCLPISHFPLATLPETSPNTSCLNILNYFQEGKAHMCVVSKEPGSSHGAIGVLTLEDVIEELIGEEIVDESDVFVDMHQHIMRQQPGPLSKRHITSYLHHLYTSSHKEHKAADQADESSPLLSPSNSNHPSEHPQQDLNNKSWKQKSNDGYDRSNAVLSPTPQVTEHGTIIPSNLASNPLNVNKSFVTIKKPANVPKIITTHTPHSSKEPSPAPHSNDKSLSAEEQQLLSDHAELSRQAVLHTQRSGQPTQVTTSTKTTRNSPDSISIPNSGANHGNENQNVTISTSYQNTKNGIVESVITVKGVPKTIIGPAKDWDESKSEYGNENINQENSNRSDDRESSSSNASLFSSIKNKFKNENANNNDRSNFTDSLSRTSNYDANGSSSTIKR
The following text describes a protein:
Function:
A probable ATP-dependent 3'-5' DNA helicase (Probable). Has a role in telomerase-independent telomere maintenance. Represses ade6 at an ectopic site.
Sequence:
MVVASEIAKVASKTARDIAGCFTCQCGTQFDNVERIVQHFKECRYRDETCKDDDIVVYEPSSFVQDEKKDKPIIVEAASEATSEEACNSSKERQLPALSALSALSTLTTSANDDLWTARLIWQSTNDTKLDNSPSSNYTDLNHKLANYGLSILSIHALMCVECECLLNVIHTAQHMQIVHKLELNEDLLWFQELRTLKLKSPTNVLQTHSSQTHVYPYIRGLPVLLNGYECVPCTKNGTGFVHAIMDTFRHHVRRTHGKVIKLENCIRRTALQTVKNKYAQRCQFFKVDYVPLNGGEEEEEEEGEEKEDAQNIKERMVDFCFSKFMEKNQQRREQQDKGENKKRQDDVDQATDNNTNTILEDDEKDNDEEEEEEIVNAREKNLLNQQFNWTAIVKKLGENWDQLVRFEYTNGIVTLDTIVNQLIRYYYRGFRHLSGMTMGMRRMFTQGGSYSAQERGLCRLEQKDTVVRYAQSAALYLIFLLRRPSADSGIRRHLEAMCGATVERKEGGSNSSSNISNVANFDSAEDDNDNDNDNDRDSNNNNNNNNTNTDDDDKLAYLELHEALKLAFLQQYDFSKNVQDLEIMEFLACMSLHKDGTSKYAYEISACFAPLIYTCRLVAACELQRLIDEKQIDLLSIPSFQTAGSIAYAHVFCFITLGQRNLYDVLYETQKVVRDIIRTEGYANTLQGLSPSTVLFQPRSNSMYPCIGDAFNNMVRLDLSELTALYEGMFAKVQDLLKELCFDMNVEKLLPISLLRSIGDDINNSKLGYSFFKESIEIRSSHSVLLRTILKNSELCHRFFPSMSKKDLTKLFGGVSDQQRNECDNYSNHYNDNSNDNDNDVFLKLHWSKSAIKKYETKASIFNELLFCLVYISAGQPARAQEMVYWTLRNGKYKTRELYLMFGRLMIYSRYDKTRNMKFAEKPIPRFLSEPLSILALRYYVLVRPLEALMKYVTTADRSKVAVYLDFMFVIAGERLQRDLPYRIFPKATYQCIQKPLGFRNYRHIAHYFKEKNIEEEMTRESYFDLQAGHTRNTALYIYGRTMDNLHYLPSDYFANFFRASYKWQELLQIRDNPTHGLLVETKHPFIKRVDQLEEALNEKLARLVGEQMVEGDKEKDKTNEEKNKDEVKAEMTQPVVNQDSHDLQDQLATTPTAPTAFHYRPGLLQPSQTSVQHCCWALSQYYGLEAKFRSLKQFQSVYFSLLNRMNLITVLPTGGGKSLSFLIPALIEKKRQTPGKVMNMVTLVLVPMMSLRQDMMLRVNEKGLLVCSGNWTAFKDVRLTLETQLPDLFILTYESALTNSGLRFFESLATLGRLARVVIDEAHLLLTSGAWRTALSRASRLSGLYAPLHLLSATFPRQLEMVARQTFCTNFYVLRETSTARENIFYFLHPYDNTEFLLDLRTLMKRTKVFEGDGRAIIFCRTKKDVEYIHRRLHQSDLFAHTHVTIYTGDVSDEERQMNFDAFRNANGKTRIMIATKAFGLGINYMGVRLVVHYGLPASSMDYVQETGRAGRDGKYAIAALFYEKYDSTWSSYVEDSMKNFLNDNTMCVRSFLASEMDGECVCCASFANCVYCSRCSDSLLGEESTVSTMYGVKPTLPETPKPAIATHSRYNASFSSSPPPQPGNSSGMSAMNTNTTSTTPVSLSELSEITLFPSSVSPTWKKSFGNANTNLKYGLEDMSLSHRRGHKRTYDEHLNNVQQGVNHDMNRVHGSVGGMSGIVGIGIGIGDGDGDGDVDSRTIHFAEYKSRVQAVKKQWVDSTDISAQLERFFRVYKDECLSCTLGNPDTEIRAHTGKACPVRLSTCYKCGKADHNLRECKLRIRFQGLCLFCGLTKFEHADSDMAYTSDCRSWARKANLISLVYYAWNNVQYRRTIADKFLQGDVRDQAFYGFVCCSTTTNSAFVLVIHYLLSDVLQIM
The following text describes a protein:
Function:
Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MKLRLDPSTQSNYHDVSISKLDWHARIDFDQELLHGKVSFVIQSARVSQALSHIILDTSYLEIKNVTINDIPTPFRVDKRRGFLGSALHIVPADEIPSSKSCILTILYSTTKDCTALQFLKPEQTIGGKFPYVFSECQAIHARSFIPCQDTPSVKVPCTFKIRSKLPVIASGIPCGTANFCNGSLEYLFEQKNPIPSYLFCILSGDLASTNIGPRSSVYTEPGNLLACKYEFEHDMENFMEAAEQLTLPYCWTRYDFVILPPSFPYGGMENPNATFATPTLIAGDRSNVNVIAHELAHSWSGNLVTNESWQCFWLNEGMTVFLERKILGRLYGEPTRQFEAIIGWGELEESVKLLGEDSEYTKLIQNLEGRDPDDAFSTVPYEKGSNFLYEIERVIGGPSVFEPFLPFYFRKFAKSTVNEVKFKHALYEYFSPLGLASKLDSIDWDTWYHAPGMPPVKPHFDTTLADPCYKLAESWTNSAKNSDDPSKFSSKDIENWSAGQKSLFLDVVYEAVSFPHNYIKRMGDVYSFAESKNAELSFRFFKLALKSKYKPLYNTIAERVGSVGRMKFVRPIFRLLNEADRAFAIETFEKYKHFYHKICASQVEKDLGLSE