The following text describes a protein:
Function:
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step. The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA. The roles of dbaB, C, E and F have still to be determined (Probable).
Domain:
Multidomain protein; including an N-terminal starter unit:ACP transacylase (SAT) domain, a beta-ketoacyl synthase (KS) domain, a malonyl-CoA:ACP transacylase (MAT) domain, a product template domain, a acyl carrier protein (ACP) domain, a methyltransferase domain and a reductive NADPH-binding domain that is required for NADPH-dependent product release.
Sequence:
MLGHRDFTTLPLSRREFLLFGPLALSFDQAAFEHLRKTIVNSEEHRWALEVLGSLPQYYATIVNAFPGINGRNEVQLEDLKGALHSGKPLATSFPLPNTLLIPLVMVLHLTEYSRFLQEISEELESGIDLFDASRHNKETVGFCTGLLSAMAVSSAGSREDFRKYAAVAVRLGLLVGVVVDSHDISSAQGPSKSISASWNSAQKREDARRIMDEFPQAYISVYYDEDRATITAPASEISDLHRRLRASGIVTAEIGLNGCFHADCYLDQLDPIIQFCDSQPDFQLPDASKVVIPTRSNATGELIRDGALHQHALRSILVEPPQWFESFTAVRDACAEDEGAIIFSFGPERCVPPSLLRVLSQKVVTVEDLDVLKRYQYSYSENDIAVVGMSCKVAGANNLEEFWDLLCTGKSQHREVPKERFSFETVFRDVDSKRKWFGNFIDGHDQFDHKFFKKSPRESATMDPQQRHLLQIAYQAVEQSGYFHSANPDRQIGCYMGVCACDYENNIACHAPNAFSATGNLQGFIAGKVSHFFGWTGPGLTIDTACSSSAVAVHQACKAIITGECTAALAGGTHVMTNPLWFQNLAGASFLSTTGQCKPFDAKADGYCRGEGIATVFLKKLSAAVADGDQILGVITATAVQQNQNCTPIFVPNVPSLSDLFRVVVKQSRLQPSDVTVVEAHGTGTAVGDPAEYDSIRSVLGGSSREKTLALSSVKGLVGHIECTSGIVSLIKVLLMLQKRMIPPQASFTTINPAIKATPADKINIPTTVKTWDAEFCAALINNYGASGSNASIVVTQPPVGTVKPSAETSGLKYPFRFCGMDEQSLRRYSKIFRQFLNRKSYSAQDLSLRNISFNVNRQSNRQLDRTLLFSVKTLEELEQKLVTFENDNDSITSLALPKSKPVVLCFGGQVSTFVGLDRTVYERVAILRKHLHTVDAVARSIGLKSIFPRIFETTPVSDTVHLQIMLFASQYACARSWIDSGIQPVAVVGHSFGELTSLCVSQSLSLEDAVKMIAARATLIRDAWGPEKGAMLAVEADLEDVQKLLAESSAGCQDVQPATIACYNGPRSFTLAGAVAAIDAVAEALATPAFSSMKNKRLNVTNAFHCALVDPLLDRLEESARELTFRAPVIPVQRATEYQTEELPTSRFVADHIRSPVFFNHAIHRLADKYPSCVFLEAGSNSTVTNMASRALGNPSSSHFQAINITSHNGWNNLVDATMNMWKSGLGVHFWAHQPSQTKEYALLLLPPYQFEPSRHWIELKNPPKLTAAPAIEEVKKEEAKVPNTLLTFVGYQDSERQQARFRVNTMIPKYDKLIRGHIIAQTAPICPATVQLDLVIESIRSIRPELASTEHEPQIHAVENLAPICVNPLRAVWVEVTADDVAQGTSWNFQVYSDDLQNGFSKTIHTTGRVIFRSISDVSLKYEFARFERHFRHQTCVELMRGGEVDEVLQNRNIYKMFAEIVDYGEDYRGLQKLVSKGNQSAGYVVKKYNPESWLDGHLADSFCQVGGIYVNCMTDRVPNDMFIANGIEQWMRSPKMRQQDPRPESYHVLATHHRPSDKAFLTDVFAFDSTTGVLIEVILGISYVKIPKASMSKLLSRLTVNDSASCPTNMPLLSKSASVNLFDAPENLSTPSLSVAPTQQSAPALSLSKVKKVKNDGPDKGQLTQRIKSILAELSGLEIAEIKDDSELADLGIDSLMGMEMAHEIEKAFTISLPESDLMEVVDVPSLIKCVRKAMSGDADSAEYTTEQSTSEAADSDDKSTNYTTPSTPGEEALDMDKSMREFLGKEGTELNLPFETVMKAFNETKNMTDDRIAEYQQTRYVESVLPMQSQMCVSLVLEAFDQLNMRIRTAPAGEKFTRISHPKEHTRLVDYLYKMLEDASLINIDGEVITRTAIQVPRPSKEIFDELVSQHPDQNAADKLTFYTGSHLAEVLKGETDGIKLIFGTQDGRELVSKLYRDWPLNRLFYRQMEDFLERLTSKLDISQGVIKILEMGAGTGGTTKWLVPLLAKLNIPVEYTFTDIAPSFVAAARKKFSKQYPFMKFRTHDIEKAPADDLIGSQHVIIASNAVHATHSLSESGKNIRKALRPDGVLLMLEMTGTLHWVDIIFGLFEGWWYFDDGRTHAVTHESRWAKDLQAVGYGHVDWTDGVRPENKLEKLIIAFASGGRYERLHIPRPLESASADCAARQAVVDRYVQEMTAGFGAATGVSPSAPLAHQEPKGCCVLVTGATGSLGCHLLAALTSLPTIASVVCLNRRSRQDPLERQHRSLLEKKIFLSEETAARVRVIETDMSKPQLGLLEEEYNYLLNSVTHIVHNAWLMNAKLPLRRFEPQLQIMRNLLDLAYGISLQRPMEKVSFQFISSIATVGHWPIWTGKSSVPEERMAIESVLPTGYGDAKYICERMIDETLHKYPDRFRAMVVRPGQVAGSSTSGYWNTMEHFSFLVKSSQTLNALPDFDGVLSWTPVDVVASTLVDLLLLPEDKTPYSIYHIDNPVRQPWKEMNVVLADALHIPRSNIIPFEKWIQRVKDYPRQVEGAEGDNPAILLVDFLDNNFIRMSCGGLLLETKKSREHSKTLANLGPVSAETARLFIKSWIDMGFLSP