lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
Subcellular Localization:
Nucleus.
Sequence:
MAENGDNEKMTALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLETMIKFNRLNRLTTDFNVIVQALSKSKAKLMEVSADKTKIRRSPSRPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLDDKGQILNIQMRRTLHKTFKGSIFAVFDSIQSAKKFVEIPGQKYKDTNLLILFKEDYFAKKNEERKQSKVEAKLKAKQEHEGRHKPGSTETRALEGKMGCLLKFSGDLDDQTCREDLHFLFSNHGEIKWVDFARGAKEGIILFKEKAKEALEKARNANNGNLLLRNKKVTWKVLEGHAEKEALKKITDDQQESLNKWKSKGGHAGGRFKGSHVFTAARRFKGKGKGNRPGYAGAPKGRGQFHGRRTRFDDDDRRRGPMKRGRDGRDREEPASKHKKRENGARDK
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MLLTTLNKYYTEAEGQAYLEALSKQWYDNRLAPTALTNSDLALQYFAQPDTNAFYQRDCNNERVKQANFGLLDHQKLREMRGIEYEARAVLPPFLHHVVQKRRFKPSLALDTAYYYILNGNAYQAPDLSSLISSRLSSALHSLSAAFKAGQGCLKRAPQSMKRKAASASKHQLKYKTQAASGIQARQVAEALSVTVNSAAKTVADAAASPSASHAVVPSEEKPDSSTAA
The following text describes a protein:
Function:
Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSLNVSRLLLPSRVRHSYTGKMGAVFIFVGALTVLFGAIAYGEVTAAAATGDAAAVQEAAVSAILGLIILLGINLGLVAATLGGDTAASLSTLAAKASRMGDGDLDVELETRREDEIGDLYAAFDEMRQSVRTSLEDAKNAREDAEQAQKRAEEINTELQAEAERFGEVMDRCADGDFTQRLDAETDNEAMQSIEGSFNEMMDGIEALVGRIERFADAVSEDAEAVRANAESVMEASEDVNRAVQNISDAAGDQTETVQQIALEMDDVSATTEEVAASADDIAKTARQAAETGEAGRETAETAITEMNEVESRTEQAVASMEELNEDVREIGEVSEMIADIAEQTNILALNASIEAARADGNSEGFAVVADEVKALAEETKAATEEIDDLIGTVQDRTQTTVDDIRETSDQVSEGVETVEDTVDALERIVDSVERTNDGIQEINQSTDAQADAAQKATTMVEDMAATSEQTASDAETAAETTETQAESVKEVFDLIDGLSEQADSLSETLSRTDTEEASAADLDDQPTLAAGDD
The following text describes a protein:
Function:
Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. Cannot use F420-2 as substrate to add more glutamates. Exhibits maximum activity with GTP, compared with UTP (66%) and dGTP (25%); with ATP, only F420-1 is observed as the product; CTP and TTP support no activity.
Sequence:
MIKEKRKVEVIGLELPIFKGGEQINLSELIAQYPIEDGDIIVIAETLISKLEGGVIDRDKIIPSKEAIELAKKTGKDPKVVQVILDEAKEIVKVGKNFIITETKHGFVCANSGVDESNIYKGIKILPKNPDESAEKIRKEIEKLTGKRVGVIISDSVGRPFRKGAVGIAIGVSGILALWDRKGEKDLFGRELKTTEVAIADELASMANVVMGEADEGIPVVIIRGANVPFGNGKGRDLIRPKEEDVFRN
The following text describes a protein:
Function:
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Sequence:
MADSKTKKKCSFCGRSENEVGFLITGMNGYICDSCATQAYEITQEALGEGRKRAGATKLNLKELPKPVEIKKFLDQYVIGQDDAKRFLSVSVYNHYKRLLQKDSGDDVEIEKSNIIMVGSTGTGKTLLARTIAKLLHVPFTIVDATVLTEAGYVGEDIESILTRLLQVADYNVPEAEQGIVFIDEIDKIARKGDNPSITRDVSGEGVQQGLLKLLEGSVVNVPPQGGRKHPDQKMIPVNTKNILFICGGAFDGIEKKIAQRLNTHVVGYTASQKTAVIDKNNMMQYIAPQDLKSFGLIPEIIGRLPVLTYLNPLDRNALRAILTEPKNSIIKQYIKLFEMDGIKLTFEDSVFEYIVDKAVEYKLGARGLRSIVETIMMDVMFEIPSESKKEYKVTLDYAKQQLEKANMARLQIA
The following text describes a protein:
Function:
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MPAAPAPTFAPLTVRALLWAVSAMGAVVLLSNILVQYPINDWLTWGAFLYPLAFLVSNLINRRFGPRAARMVAWCGFALAVVLSIWLATPRIAIASCSAFIAAQLLDISVFDRLRNGNWWRAPIVATTCSATLDTAIFWSIAFAGAGLPWISWAAGDLAVKLGMGVFLLGPFRALLWRSAPRASG
The following text describes a protein:
Function:
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Subcellular Localization:
Nucleus.
Sequence:
MAATSRAKKRIRVTRKPKSCPNPLFEKWLIELKEDAVRKESRLQYVYGKALKSLQKYPLVLESAKECKVLQHFGEGLCKIIDKKLTEHIASGGYFFKTGTLGNCSESDGSDEDDRPRKQSKNASKDYIPTRRSGAYALLMALYKHATDGYLKKKDLQDLAQPYADVSFSQTDILNAQYYNAWSSMSTLINKHLVGKTGNPAKYHLTDSGRNLARRLDKAEFELQSSSISSAPAKPVIEPSAPEEEVVVEDPEPEPYVHVRDKITLRAGEYDIVLCVDTAEVSGSSGSGNNQKESAAKSFQNCGVLYDVRKLSIGDYSWICKPKASSGTRSDRELVLPYVVERKRMDDLVSSIKDGRFKEQKFRLKHSGLVRPIYLIEEFGNRQNLGMPEASVLQAIANTLIIEKFQIHWTQKSDESVGFLVQMTKQLTELYRGKTVTSRGCQEKVGHDWQTSLVTFKEVYTNSTKSKPLSVTQMFAKQLMQLHALSADKAEAIIKIYPSPYVLMEALKAAGSSASTLLASLEYGKAKRNKIGLTISSLLAKLYTEDRLDK
The following text describes a protein:
Function:
Controls the rotational direction of flagella during chemotaxis.
Subcellular Localization:
Cell inner membrane. Cell membrane; Single-pass membrane protein.
Sequence:
MAAAKKPEKTEEKDEKKKGGKKPILLIAIGVVVLAAAGGGAWFFLGHKGEEKDGKHAAPKVAEVPKPAQYFPMDPAIVVNLADPGDGPQYLQVEVQLVTRDPEELKLITENAPAIRAHLLMLLSQVKAADVADLPGKQKLQKSALAEAQKVMTSETGKKCVEELLFTSFVTQ
The following text describes a protein:
Function:
Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular Localization:
Secreted.
Sequence:
MMNNMKLLIIAVMIISAALLPALVVGSRPVKCDNCMDGGEKEEIMKMSSGVDVSHRILQAKRFIDYEALKKNLPAKPDGKPDKPDNKYRRGCSAATGCYRFTN
The following text describes a protein:
Function:
Involved in lipid transfer from the endoplasmic reticulum (ER) to plastids. Specifically binds phosphatidic acid (PtdOH).
Subcellular Localization:
Plastid, chloroplast outer membrane; Single-pass membrane protein. Endoplasmic reticulum. Note=According to PubMed:18689504 TGD4 localizes to the ER (GFP experiment), but PubMed:22269056 found that TDG4 was located in the chloroplast outer envelope using cell fractionation.
Domain:
Amino acids 110-145 are necessary and sufficient for phosphatidic acid binding, while amino acids 1-80 are only necessary.
Sequence:
MNRMRWVGEGDIWDLDMSTPVTLEGTARAVPDDPLPLGLSRGTRLSRPKQVEFFHRFMASPLIPSFSPIRPNTGDGGGGGFSLQRVLTLPFSNNWLVSLLGQFDVQRFVTEIDKTKAFGRGSSSTVASRLNTIGKHLKDKSLYALGFCSEFLLSPDDTLLLSYDAYKGDLDKNPRAKAIFNHEFPLHNLTAEAVWPGLFVDKHGEYWDVPLSMAIDLASLPAESGPSYHLCLHHNSGSPKKLHSDTMEVPPPSLLPGLSLKSAVSYRTNMDLWRGTTPKLETCKPYDVFLSSPHVAVSGIIGSVMTAAFGENSIRSKFENDSEGVGGFSLHFPSVNSGFMADALGRASLTAQYGNFQKFFFDLTRFHARLDFPHGLRFLTGATSVAQDLLNSRQPSLEAFQKICPEVLVSLQQQIVGPFSFKVESGIEIDLRNGANPVTVDKTVFAIEYALQVLLSAKAVVSYSPKQNEFMVELRFFET
The following text describes a protein:
Function:
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPALREGNPTPRYQALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVATEKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQTLDEFRGKVRTLDGTAESTR
The following text describes a protein:
Function:
Required for meiotic induction of recombination, viable spore production and chromosome synapsis. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.
Subcellular Localization:
Nucleus. Chromosome. Note=Localizes to chromosomes.
Sequence:
MSRGKLEDMEQKETSEVDWIICFALIQSRNPTLWKRALSRKKGDVEDVGALKSEKNLKINPRENSKHIYKWVAPFENGFLNNKSLFAHLEPIYNFLCQNKYKSFEDAVGLKELQSFSKDVSTADINNWFLPRYKILLKILSLKTKEIDFRGLSQVFQTLQILLVSHYSHRIDSDSSFKRTLIDVHVFNFIAKFLFNRILLKKNQNDPKWLQNFYDQGDGKHLCDKVDYKRLCSLHFTLIYSIINIQLIKIKTNQTFEPQILKYVSVLKLIEHILIIIESLIHVLIRFVSKHKLICINRKKAYCRVYLERELSLKKTYLKNFYSVISGVPEKELGGLLKILKIVILSLLETFESIEWQHLKPFLEKFPAHEISLQKKRKYIQAALLITAERNLIARFRLSRWFNETENI
The following text describes a protein:
Function:
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Sequence:
MTQIGPFDLEKKAAVVAVILEKPLETSKKAAEKGADILEVRLDLLGIRNPESAAKIIREIKSETGLPVLVTNRSVAEGGKWEGKEVDRTELLVALLSLKDGPDAVDIELSASREDRDKVIKAAKAHGKTVIISSHDFSKTPSPQEMTATLAEMFLAEADIAKIAVMPGSMEDVLNLLKVTLEFKNTGKTVCTIAMGKPGKHTRVVAPLYGSVLTYASIESNAVAAPGQLPVDEVKKIMEMLK
The following text describes a protein:
Function:
Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation.
Subcellular Localization:
Cytoplasm. Melanosome. Note=Melanosomal localization is mediated by RAB9A.
Domain:
The Rab-GAP TBC domain possesses GTPase activator activity.
Sequence:
MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRIIYPGHRHEHNAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system involved in plasmid partition. Inhibits the anti-DNA gyrase activity of toxin ParE; reverses and restores gyrase catalytic activity in vitro. The parDE operon alone is capable of stabilizing an RK2-derived minireplicon under defined growth conditions in several different Gram-negative bacteria. It does so by the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Binds its own promoter, autorepressing it; gentically only ParD is required for full autorepression.
Miscellaneous:
MISCELLANEOUS: Plasmid IncP-alpha RK2 is maintained at 5-8 copies per chromosome.
Sequence:
MSRLTIDMTDQQHQSLKALAALQGKTIKQYALERLFPGDADADQAWQELKTMLGNRINDGLAGKVSTKSVGEILDEELSGDRA
The following text describes a protein:
Function:
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
Domain:
Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.
Sequence:
MATIKDVAKMAGVSTTTVSHVINKTRFVAKDTEEAVLSAIKQLNYSPSAVARSLKVNTTKSIGMIVTTSEAPYFAEIIHSVEEHCYRQGYSLFCVTHKMDPEKVKNHLEMLAKKRVDGLLVMCSEYTQDSLDLLSSFSTIPMVVMDWGPNANTDVIDDHSFDGGYLATKHLIECGHKKIGIICGELNKTTARTRYEGFEKAMEEAKLTINPSWVLEGAFEPEDGYECMNRLLTQEKLPTALFCCNDVMALGAISALTEKGLRVPEDMSIIGYDDIHASRFYAPPLTTIHQSKLRLGRQAINILLERITHKDEGVQQYSRIDITPELIIRKSVKSIL
The following text describes a protein:
Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular Localization:
Nucleus.
Sequence:
MVVFKNRYMVLEMVVGHGLRLADVKITQNDVASAIQESLLVNFGEYGLASSLPSLQVKYVNGGTGICVVRSSRKQYRTIWAAITFVTEIRKLPLVFNLLDLSGSTSACRRAAQQCDSEKLRLLKLDKHTLSAEQLEYAELMQSRLSSID
The following text describes a protein:
Function:
May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MVSNFFHVIQVFEKSATLISKTEHIGFVIYSWRKSTTHLGSRRKFAISIYLSEVSLQKYDCPFSGTSFVVFSLFLICAMAGDVVYADIKTVRTSPLELAFPLQRSVSFNFSTVHKSCPAKDWKVHKGKCYWIAETKKSWNKSQNDCAINNSYLMVIQDITAMVRFNI
The following text describes a protein:
Function:
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
Subcellular Localization:
Nucleus.
Sequence:
MASDLESSLTSIDWLPQLTLRATIEKLGSASQAGPPGGTRKCPPGSPTDPNATLSKDEAAVHQDGKPRYSYATLITYAINSSPAKKMTLSEIYRWICDNFPYYKNAGIGWKNSIRHNLSLNKCFRKVPRPRDDPGKLPQDSPEQEASKSPRGGIPGSGEASLPPEGNPQMSLQSPTSIASYSQGTGSVDGGAVAAGAPGRESTEGPPPLYNTNHDFKFSYSEINFQDLSWSFRNLYKSMLEKSSSSSQHGFSSLLGDMPPSNNYYMYQQQQPQPPQQQQQQQQQQQPPPPPPPAAPAQGPSAVGGAPPLHTPSPDGCTPPGGKQAGAEGYGPPPVMAMHPPPLQHGGYHPHQHHPHPHPAQQPPPPPPQAQAQAPINSTGFAFPPDWCSNIDSLKESFKMVNRLNWSSIEQSQFSELMESLRQAELKNWSLDQHHIANLCDSLNHFLTQTGHVPPQGSSHRPPAPARISDSCALTSGKQEPAMNQVNSYVHPQAPHLYPGPSPMYPLPTQDSAGYNRPAHHMVPRPPVPPPGANEEIDDFDWDLIT
The following text describes a protein:
Function:
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGSLYRSEEMRFCQLIVEKDAAFSVVAELGKQACVQFKDLNPDVNSFQRIFVRDIRRFDEMERKLRFLESQIQKDGMQIGGRVDDGDYEAMPTAELNQLETTLNDLERDVKNMNESDALLKKNFADLKEWDAVLNKTDEFFAGGVDSEAQEELEEQEELGGGRQAEKAPIQYVVGVIRRERIPAFERVLWRACHHTAYVRASDIEEQLEDPETGDKVNKSVFIVFYKGDRLRSIINKVADGFKAKLFANCPRTSKERQSSVHEVRARIADLQTVIGQTREHRFRVLQAAANNHMAWLKQVNLQKSVYHTLNLFNFDGIGRFFVGECWIPLRDIDNVREALERATEASGSAVRPVLNVLETSDEPPTYNKTNKFTAVFQSIVDSYGVASYLEVNPAPYTIITFPFLFSCMFGDLGHGILMLLAGIYLVVREKNLIARNIKDEIFGMFFGGRYIILLMGLFSIHAGFIYNDMFAKAFNIFGSRWHNPYPNANVSHWIHEEEVAKRDILFEVTGQPHQFFSRSNKPRFTNQYSIALSDWRGHLDPGVAYDTAAGPYPFGVDPVWNVAENRLNFLNSMKMKLSVILGIGQMTFGVILSLQNHRFFKSKIDIFTVFIPQMLFLGCIFMYLCLQIILKWIFFWVKEEVIFGQLYPGSHCAPSLLIGLINMFMLKPREAGFVMNETRVGPNNLLIEKEGCYLTQWYPGQSIIEMILVLIAVICVPIMLFGKPIAFILEQKKHKKAHAENITVHANVLTEETEIIANGNGKAEGGHSSGGGGGAHHGENFGDVMVHQAIHTIEYVLGCVSHTASYLRLWALSLAHAQLSEVLWHMVLSNSFNASHNLAIGGIAIYIVFFIFAVLTFSILVLMEGLSAFLHALRLHWVEFQSKFYLGLGYPFVPFSFKEQLSKVELQAAA
The following text describes a protein:
Function:
Probable phospholipase that hydrolyzes phosphatidic acid.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQESSQEEPVHYVQWFYLSNYDLYDETSSMELTGAQSWRRFLNYDNNALEAKYNEIITEEVSQEPNQKNVIVGISGLHVVNLPTLTLKPLYWPSASKNDTLRVVRGLWMYEDTGLPVINELSDMLEEGYQEVKPYAVNWDNVLKEEEEGKDSQDDPSVLSHKRNKSSKELIDAMQWPLKPTSSGKYVFYEDGYRALICQGGLLSYFSKGTQSRRTSIKGMPVVRDFPYFEDDGFNGPKQVTDLFLVVHGIGQKRSETEERFLFTKTCNVFRSLIQIQKNIMKEDPLIRNDYEPQLLPICWRNKLNFNSYIKPVAGDEGRVEDEEFEENRFSIEDIEIDSIPAVRRLLGDVMSDIPYYMSHHKESIIKSVIREANRVYHLWKDCNPYFLENKGRIFIIGHSLGSTVVFDILSLQPTFVKEITIDDDESCFIFDTNGFFCFGGPVGFFLHLNQQSIIPRRGRGSSRYEINKNFINSDVPKSYTYDGYDRYGCLAVDSFYNIYNHLDPVAMRLNPTVDLSFSKGIHPTRILFTRKSSSILRMISHSNTDPVELRSYNQSLQQNKNNEPTAVVPLEPEQTVELETRNFRREERAKWRMQELNENSQLDYVFTSAHGVISNKYLSMLSAHSSYWSSEDLACFLVVETGRNFGIANSIEQFRGKHMPRIFKGDSS
The following text describes a protein:
Function:
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MNLLMPFLPIIYAGIIVAIGTFFSYILSIIAGFVWGLIFFLVVFLFALLIVHPKSYPWRYIVPSFLLMFMFMIYPIIYTIQIAFTNYGTGHILTKTQVIEQLEKETFLPENTQNFEYEIYKAKTGEILLLFRDKSKNIYKIEDKKLIKIGEGDFPKEYSNYKIVPQTQKYGEISKLQNIKIELENDTFLQMSDLNTFSIYRQRYKYISTEDVLIDNLTGEKLIPKNGFFVRPNGQEILPGFVTNVGIENFIRLFKDERVSKPFLRVFIWNVLWATLTTFINFAFGLFLALLMNDKNLEFKGIYRTLLIVPWAIPSFISLLIWVGLLNTEVGVVNRILLSIFGVKIPWFLETKWARLALFVVNLWLGYPYAMTVCLGSLQSIPEELYEAAKVDGASYFQQLKTITLPLLLTAIGPLIVGTFAFNFNNFNVIYLLTGGKPPMADISSVAGTTDILISYTYKLAFEGGRGQDYGLAATISIIVFLIVALLSLLNFWISGMFKQEVRYE
The following text describes a protein:
Function:
Involved in positioning the distal bud pole signal.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Bud tip. Note=Found at presumptive bud sites, bud tips, and the distal poles of daughter cells.
Sequence:
MIQSDEDNLDSSETTASTSYSGTSSVSSRLQLRTSLFFENLNGAHGNPDAETEMATVAYETTSRGQGFAVYINNERFSQIMGASTSSSSSSNSSSITQFHDTQDNNIPSNTTVRPTSLRRDNEDTVPLRNVTPSQNAAVRPERAVNSPSSQRLSCALTISTSVLMGEDVEGSPIEQEHSRVVSSLYSSLANRGNDESKNGTPPRPTSIEPNETTEHSFFSYHYDDTLEPDVEEAVRLTKNKTSNVNFISSTGSKGEGETEDEVIDQYEPVNESKFIPHKLKIPEKAGSIKSSTSDDSHSPGAPGTSARKIKIPQSPSLIGNILIPSHNSDSSNESSPKDHIGHNNEEKFSSKSTRKPSTSLEEEGPPIGLPSIPVLRSVSGPSKWTKTPLRLESGNSTKSDPFSRYEGHKTPSPLTKMNKKKNKTLPEHGQPLVLAPIKSQSSESDTGQNSIIEKPARSIRRKQQEKTDNRKEDRHDAENIDLEARMPIQHIDTASIHSFDSGQNGFRDVYSIENIIVILLCCSIVPPLFFIIGCSSRRKLVSDYRLMRLLMNKEHRAALLQGFIWDVDLRWFRMFCLILGAAETVIVMAGIAIGFGVGITRE
The following text describes a protein:
Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MKVQETRSHVHALGEEEKVMTRKQKAESKAHEVEHSPKKAKVEKEDGHINGKSETGVAEEYDEFCKATTEHLPLEQMRDILEANGLDSSGSDLEITRRCQDLLFYGALDKCSVCNGSLEFDGRRYVCRGFYSEWASCTFSTRNPPRKQEPIKLPDSVQNSLASDLLKKYQDPSHRPHRDLGLAEKPFTGMMISLMGRLTRTHHYWKTTIEKHGGKVANSIIGSTCLVASPAERERGGTSKLAEAMERSIPVVREAWLIDSIEKQEPQPLEAYDLVSDLSVDGKGIPWDKQDPGEEAIESLSAELKLYGKRGVYKDTKLQEQGGKIFERDGILYNCAFSVCDQGRGLNDYCVMQLIVVPENRLHLYFKKGRVGDDPNAEERLEEWDNVDGALKEFVRLFEEITGNEFEPWEREKKFQKKPLKFYPIDMDDGIEVRHGALGLRQLGIAATHCKLEPLVANFMKVLCSQEIYKYALMEMGYDCPDLPIGMVTNLHLKKCEDVLLEFIDKVKSLKETGPKAEAVWTDFSQRWFTLMHSTRPFNFRDYQEIADHAAAALEGVRDITQASHLIGDMTGSTIDDPLSETYKKLGCSISALDKSSDDYEMIVKYLEKTYEPVKVGDIEYGVSVENIFAVQTGGCPSYEDIIKLPNKVLLWCGSRSSNLLRHLQKGFLPAICSLPIPGYMFGKAIVCSDAAAEAARYGFTAVDRPEGFLVLAIASLGNEITELKTPPEDASSLEEKKVGVKGPGKKKTDESEHFVWKDDIKVPCGKLVASDHQDSPLEYNEYAVYDKKRARISYLVGVKYEEKEEKGAVIDTAE
The following text describes a protein:
Function:
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP.
Sequence:
MGSALGRARRTLSGRPFQRAPCRTRRALSLSAALRNVTKAQGGCPKSLVLWGCRPKRPRKRRTSLKLAWRGTFCSSSLKISEDTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDTPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKAGSGKNDHDEKVVEKLEALSVKEETKEDAEEKQ
The following text describes a protein:
Function:
Plays a role during G1 to regulate entering or exiting the cell cycle. Involved in stress responses. Has a role in cell wall integrity signaling. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1. Important regulator of the actin cytoskeleton rearrangements in conditions of cell wall expansion and membrane stretching. Specifically required for the actin reorganization induced by hypo-osmotic shock. Multicopy suppressor of 1,3-beta-glucan synthase (GS). Activates GS upstream of RHO1. Acts positively on the PKC1-MAPK pathway. Activates transiently SLT2 during alkaline stress, which leads to an increase in the expression of several specific genes.
Miscellaneous:
MISCELLANEOUS: Present with 664 molecules/cell in log phase SD medium.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MRPNKTSLLLALLSILSQANAYEYVNCFSSLPSDFSKADSYNWQSSSHCNSECSAKGASYFALYNHSECYCGDTNPSGSESTSSSCNTYCFGYSSEMCGGEDAYSVYQLDSDTNSNSISSSDSSTESTSASSSTTSSTTSSTTSTTSSTTSSTTSSMASSSTVQNSPESTQAAASISTSQSSSTVTSESSLTSDTLATSSTSSQSQDATSIIYSTTFHTEGGSTIFVTNTITASAQNSGSATGTAGSDSTSGSKTHKKKANVGAIVGGVVGGVVGAVAIALCILLIVRHINMKREQDRMEKEYQEAIKPVEYPDKLYASSFSSNHGPSSGSFEEEHTKGQTDINPFDDSRRISNGTFINGGPGGKNNVLTVVNPDEAD
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase.
Subcellular Localization:
Endomembrane system. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Domain:
The RING-type zinc finger domain is responsible for E3 ligase activity.
Sequence:
MNDLRHVIRGFDLNAEPSVDDELEQEVEELFERERRSMHEERRQQIEAALPGRNRARLSRARPDPRPRNNQIATPVEQIVFVVDDDEEEEDDEREQRVRESSEKEETFFECNICIDMARNPVLTCCGHLFCWSCLYQWLHVHSDSMECPVCKGEVEDTDITPIYGRRSDSTDQVTEAESGLRIPPRPRAHRTESARETLLSATSALGFEEVFSRIGVRFDMICRWPPTQNLAGSFWVNGPSGSVPIQIMIGREQRREELAGGSPFPAAPAQNAVGPQRGAMDFTQGASSSYNSAISEARLIQMQLLRHQAQSSASSLRYISSATDHADERRGLPAYFQGHHPMGGNHIHHHQPLQYHNHPPAGFPDFAQFNAPNLDQPSPDDDDRNSLFTSIEVAEIQSGSQLIVDGFMGRETMGPIAAATSSRRRATDPRASDMNSRMTRATRRRFS
The following text describes a protein:
Function:
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Subcellular Localization:
Cytoplasm.
Sequence:
MFLRSVQLHDFRNYAEADLELTSPKTILVGDNAQGKSNLLEAVQLLATGRSTRALRDRELIARGKEQARVAATVERLGDTVELEMILRAGKRRTVRVGGETRRTQVEALGYLHCVSFSSLDLDLVRGAPETRRDWLDGILLQLEPVYTNVLAQFVQALHQRNALLRSTELSPDALAEQLPCWDDLLVRAATPVMRRRHRLIERLAPLARRWHGSISGGRETFAVRYQPQISFEQEDAQSVQQALQELLKEKRTLEGRRGTSLVGPHRDEVDLSIDEIPARQFGSQGQQRTLVLALKLAELELLEQVTGEVPLLLLDDVLAELDLHRQDQLLGAIQERVQTIVTTTHLSLFDSQWLQSATVLTIEKGRIGSPPAPA
The following text describes a protein:
Function:
Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing. General coactivator of nuclear receptor-induced gene expression.
Subcellular Localization:
Nucleus. Nucleus speckle. Chromosome.
Domain:
The N-terminal region can bind RNA; preferentially binds 5'-CGG[AG]GG-3' motifs; The non-classical LXXLL motifs are not required for nuclear receptor coactivator activity; The C-terminal region is necessary and sufficient for regulation of transcription and nuclear receptor coactivator activity. The C-terminal region is not required for RNA binding.
Sequence:
MGRSRSRSSSRSKHSKTSKHSKKRSRSRSRSRDRERKRRSKSRESKRNRRRESRSRSRSNTATSRRDRERAASPPERIDIFGRALSKRSAVDEKQKKEEEEKKVEMERQRRIRQQEIEERLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRHAELAAQKAREEEEKSKREELEKILVDNNRKIADAQAKLAEDQLRIVEEQRKIHEERMKLEQERQKQQKEEQKMILGKGKSRPKLSFSLKASE