lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for the transposition of the insertion element.
Sequence:
MRRTFTAEEKASVFELWKNGTGFSEIANILGSKPGTIFTMLRDTGGIKPHERKRAVAHLTLSEREEIRAGLSAKMSIRAIATALNRSPSTISREVQRNRGRRYYKAVDANNRANRMAKRPKPCLLDQNLPLRKLVLEKLEMKWSPEQISGWLRRTKPRQKTLRISPETIYKTLYFRSREALHHLNIQHLRRSHSLRHGRRHTRKGERGTINIVNGTPIHERSRNIDNRRSLGHWEGDLVSGTKNSHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELARHLEFTVSTGVKVYFCDPQSPWQRGTNENTNGLIRQYFPKKTCLAQYTQHELDLVAAQLNNRPRKTLKFKTPKEIIERGVALTD
The following text describes a protein:
Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MGVILENGLNEGVGIWGAPTSTLDWCEENYIVCKYMAEFWNTISNIFTIVLPMMGYAMDWSSPLEVHFRLQYVALIVVGIGSWCFHGTLLYQLQLLDELPMIYGSAIMLYALFQVPSQPKKHNILSSLFLTTYSAWTTYIYLTGKNPNFFFVCYGFLVFLIIVQTALINSRMHHLNADDSLFRAAIFLFLSGFALWLIDFHFCPVLRAIRARLPYPISEIFQLHAWWHLGSGIGTYLYILHTNRLRLLYLGYDSHLTYKFALPYIQHSRSKQDHKHQ
The following text describes a protein:
Function:
Required for transcriptional activation of the fecABCDE operon by sigma factor FecI. Undergoes sequential cleavage to produce an N-terminal cytoplasmic fragment which is released from the membrane and binds to FecI, allowing it to activate transcription of the fecABCDE operon which mediates ferric citrate transport. In the absence of citrate, FecR inactivates FecI.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein. Note=Contains an internal twin-arginine motif immediately upstream of the transmembrane region which allows it to be translocated across the inner membrane via the Tat system.
Sequence:
MNPLLTDSRRQALRSASHWYAVLSGERVSPQQEARWQQWYEQDQDNQWAWQQVENLRNQLGGVPGDVASRALHDTRLTRRHVMKGLLLLLGAGGGWQLWQSETGEGLRADYRTAKGTVSRQQLEDGSLLTLNTQSAADVRFDAHQRTVRLWYGEIAITTAKDALQRPFRVLTRQGQLTALGTEFTVRQQDNFTQLDVQQHAVEVLLASAPAQKRIVNAGESLQFSASEFGAVKPLDDESTSWTKDILSFSDKPLGEVIATLTRYRNGVLRCDPAVAGLRLSGTFPLKNTDAILNVIAQTLPVKIQSITRYWINISPL
The following text describes a protein:
Function:
Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.
Subcellular Localization:
Mitochondrion membrane; Multi-pass membrane protein.
Sequence:
MRPQGVAFVALPLLGPTLVWLLTHRWMSGWCNNLRKPPWYPSHRALLLVWTAFYSLTGYASYLVWKELGGGLGWPLALPLGLYSVQLAVSWTVLILFFVAHSAGLALLHLLLLFGLVVSMALIWHPINKLAALLLLPYLAWLTVTTSITYRLWRDSLCPGHQPRLMGEKND
The following text describes a protein:
Function:
Catalyzes the hydrolysis of dATP, dADP and dAMP into dA. This step is essential for Z-genome synthesis (containing aminoadenine instead of adenine). Specifically removes dATP and its precursor dADP from the nucleotide pool of the host, preventing the incorporation of A into the phage genome and favoring the integration of the Z-base into the viral genome.
Sequence:
MTLQITETYERLRASHISRWGIVQTTYPQNIAEHMWRVWLLCRDWGAAAGMPQHTVRQACEFALVHDLAEIRTGDAPTPHKTPELKELLAGIEAQIVPEVAELEATMAPEARELWKFCDTAEAVLFLKVNGLGAHAYDVQHLLMEQMKRRLMDSVLDVEVQDELMFQFERTIKKT
The following text describes a protein:
Function:
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
Sequence:
MSNFKISEDKLELDSLVKSCLCNKSSVKDAANKDNLTDLVVARVANQKLLKNKIESWRKQHEDWESLASFIKGHISRRLKKRKSTDKIIEKVEALKDNVENVKNEKVEKVENVKNESKPSSKPNEAKTVVKDSNSKSCANNQTSSPHSCEAADDDASITKSQSDEIVLMSSHDMIVKRCRMDECTDEIFVGSAVPAKDPSITEATSNIKNEKFDSFFEGGEDSDDDEDKKSCAVILSSHNDIRSQFVSSLGNPNKIFKKTANKSSFPEDRNKNAHKQSKSFKAESKKDNKGKEELKETKLHPSWEAKRKLKEKLAPNVKFMGKKIIFDD
The following text describes a protein:
Function:
Multi-domain repressor protein that negatively regulates transcription of the quinate utilization pathway genes. May mediate its repressor activity by binding directly to the qutA activator protein.
Domain:
Is homologous throughout its length with the C-terminal 3 domains of the pentafunctional AROM protein. The function of the 2 C-terminal domains may be to act as a molecular sensor that detects the presence of quinate pathway intermediates as a prerequisite for the presumed conformational changes necessary for the control of transcription regulation.
Sequence:
MSILVRPPKRRLADTENLDQNHRRVLRDFGQGNSASTPINTSADYGRFDERPGSGDGSRYASPFQELSSSQGSLTRVEDSLQTRRKFPPNASIVLIGIRGTGKSSLAVMLAASYGRRVIEADLYFQRVTGRCRGVYKREHTLSEYRRQEAIVMESLLMEHQENCVIVCGPGDVERNGQMRLREYAKTHPVIHIVRDLESIQSYLKARDTEKVRRFLELSGPIYRSCSNLEFFNVSEKGISDQPSAKDSQHYTQWDAEVDQRTQTTTPFLMLKRLQRDFLRFVALATGNIPELRNQLSPFPLHMQPIESRKFTYAATVPISHLLENDVDIEELESTADAFELKIDVSAAPSARLGTESNLADSISHTVATVRRNIIVPMIYHVESSVFPDSAPLRRSDASYLELVLHGLRLGPEFVTVDLSFEDSILSQIIGTKGSSKVIGHYSQTQPPPQGWSDPEYEAIYERAKKLGCDMVRLTQPATTIDDNFAVERFRHQIKTLPGPQLPVIAYNSGPLGRQSCCFNPVLTPVIPRSLISQSGTKGLPSITIQEAQEALYSSFVLDPMQFFVFGANTTYSLSPAMHNAAFKVRGMPHIYRIHQSPTLRGINYLVENPNFGGTSVSLPYKTEVIPLLHSMSPHARAIGAVNTLIPIRNLEGSTDNALDLEKNRAGPIKGLHGDNTDWIGIGICIRRGLSPANAIRPSTTGLIIGAGGMARAGIYAMIHLGVQNIFIWNRTVANAEKLAQHYMRLNLCTLGGSGSASYTIHVLKSLQESWPANYKQPTIVVSGIPAHRIGDQPAPNFQLPPQWIESPTGGVVVDLAYKPLNTPLMRQIRSLSHRGWAALDGLDVLPEQGFAQFELFTGCRAPRRLMRTVILQEYKEEEQGEEYDQSAMRTRLENLDGQPM
The following text describes a protein:
Function:
Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.
Miscellaneous:
MISCELLANEOUS: Present with 2360 molecules/cell in log phase SD medium.
Subcellular Localization:
Vacuole.
Sequence:
MAANSVGKMSEKLRIKVDDVKINPKYVLYGVSTPNKRLYKRYSEFWKLKTRLERDVGSTIPYDFPEKPGVLDRRWQRRYDDPEMIDERRIGLERFLNELYNDRFDSRWRDTKIAQDFLQLSKPNVSQEKSQQHLETADEVGWDEMIRDIKLDLDKESDGTPSVRGALRARTKLHKLRERLEQDVQKKSLPSTEVTRRAALLRSLLKECDDIGTANIAQDRGRLLGVATSDNSSTTEVQGRTNNDLQQGQMQMVRDQEQELVALHRIIQAQRGLALEMNEELQTQNELLTALEDDVDNTGRRLQIANKKARHFNNSA
The following text describes a protein:
Function:
Transcriptional repressor of the rtcAB genes. Interacts with sigma-54.
Sequence:
MRKTVAFGFVGTVLDYAGRGSQRWSKWRPTLCLCQQESLVIDRLELLHDARSRSLFETLKRDIASVSPETEVVSVEIELHNPWDFEEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGPGEVTIIDLDLSRYNAIASRFAEERQQTLDFLKSGIATRNPHFNRMIEQIEKVAIKSRAPILLNGPTGAGKSFLARRILELKQARHQFSGAFVEVNCATLRGDTAMSTLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGADEQAMLLKAIEEKTFYPFGSDRQVSSDFQLIAGTVRDLRQLVAEGKFREDLYARINLWTFTLPGLRQRQEDIEPNLDYEVERHASLTGDSVRFNTEARRAWLAFATSPQATWRGNFRELSASVTRMATFATSGRITLDVVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRMQLEHVIAICRQAKSLSAAGRQLFDVSRQGKASVNDADRLRKYLARFGLTWEAVQDQHSSS
The following text describes a protein:
Function:
Dual-functional monooxygenase/methyltransferase; part of the gene cluster that mediates the biosynthesis of pseurotin A, a competitive inhibitor of chitin synthase and an inducer of nerve-cell proliferation. The PKS-NRPS hybrid synthetase psoA is responsible for the biosynthesis of azaspirene, one of the first intermediates having the 1-oxa-7-azaspiro[4,4]-non-2-ene-4,6-dione core of pseurotin, via condensation of one acetyl-CoA, 4 malonyl-CoA, and a L-phenylalanine molecule. The dual-functional monooxygenase/methyltransferase psoF seems to be involved in the addition of the C3 methyl group onto the pseurotin scaffold. Azaspirene is then converted to synerazol through 4 steps including oxidation of C17 by the cytochrome P450 monooxygenase psoD, O-methylation of the hydroxy group of C8 by the methyltransferase psoC, and the trans-to-cis isomerization of the C13 olefin by the glutathione S-transferase psoE. The fourth step of synerazol production is performed by the dual-functional monooxygenase/methyltransferase psoF which seems to catalyze the epoxidation of the intermediate deepoxy-synerazol. Synerazol can be attacked by a water molecule nonenzymatically at two different positions to yield two diol products, pseurotin A and pseurotin D.
Domain:
PsoF is a unique bifunctional enzyme catalyzing two different types of reactions at completely separate steps of the pseurotin biosynthetic pathway and comprised an unusual combination of two domains, one homologous to a methyltransferase (MT) and another to an FAD-containing monooxygenase (FMO).
Sequence:
MTRIRPDYDAIVIGAGFSGVRSLWELRRLGLTARCFDAGSDVGGTWWWNRYPGCRTDGEAWVYALKFLPELLEEWDFTERYPPQEEIQWYLSRVLDRYDLRKDIEFNTEVKSAHYSDHDSIWKITTASGKVATARYFLPATGITSIPKEPPFPGLQSFKGEVYQTSTWPAHEIEFENKRIGVIGTGSTGIQVITKLAPVAEQLIVFQRTPNYVIPAQNYPLDEKKREDIKKTFDATWDIAKRNLAGHAVKHSGRMVASAGGPEEIQRVFEDGWARGCYDFQLGTFDDSFMDPHANAVTSDFIRQKIRSIVRDGDTAEVLCPTYPFGARRPPCADGYYETFNRSNVKLVDIREDEIEVYDQGIKTASGAEYELDMIILALGFDTGTGAMNKIDIRGSQNRSLRESWTRRLETFAGVLVHGYPNMFVVCGPHLPAGNQPVSLEAFASWIGKTIEHMETNGLASIDVSNEAMDAWTTHVEQVWGGSFLAKHAHEQGSWFVGTNIPGKPSRIMFYFGGMVNLEPWLIKELETGWSSMSFTRLDGAEASNGVSKQTVGGVHVTPEMLESVQIPLEADKVGMTPAEKSKLVNAATAVYIDMAVEEMRSRGLAPKADYRVHWWKVMQDFVDSGEGQRVLQETSLTNQELERVIAKLGIEGEVIARMGPEIVNILTGKTHALAHIMRDDLLFRVYLSDEGRRANRYMAEYARLLTSQRRDIRILEIGAGTGGTTSEVLNLCSPNGESFCAEYMYTDLSPGFFNAAKTTLKKWESHLAFQVLNIEDDPAGQGFKEHTYDLIIAANVIHATARLTNTLSNVHKLLKPGGVFGLVELTRLTPFYNLTFGSLSGWWAGVDEGRTESPLQSPQQWNSLLKQTGFSGVDLAAYDLPGPERHSCLLLSTALSNSVTTNGH
The following text describes a protein:
Function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Sequence:
MASLIPSVPKAKGILFQQLHFHPLYSHCLRRGHATAVVAHPLLPKTNLITALCNQEYHDSCNTIRGPLSRTTSSIRYVSSADSSKPSSTPQRTRPRIVVAMSGGVDSSYTTIIMYKICDGIEVIGLHMSNWNALDEDPDISNATNTREKEYTDAQSVAQHLSIPLHRVSFASEYWIQVFEPFVESLAELTMPNPDYGCNTFIKFGAMKKYAMGQMNADFVATGHYAQLWHRGYTGDNDSSGVFPDRSKDQSYFLSGVKGEAFRNVIFPLGHLAKSQTQQTVRDIAHQAAIPTASKRDSMGICFIGKRNFGQFVSQYLPEPPAPGTFVDVDTGEIVGYHEGSMHYTIGQGAKISGASARYFVCGKGSTGDDGNTVFVCNSTHHPSLYTDELSVDFDAFNWIGLGEKSDTDSFGHVPYPLVEGRPIKLLARTRHLQPLAQCTVSWQRSRDANSLGKLTVQFEKPMRAITPCQVVSLYAGSDGLICLGGGPIKGRGSSYLERGMDVSLSMLH
The following text describes a protein:
Function:
Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRKTSVWILALLIRCVLIWLGTYISDPPALSMTDIDYLVVWDGVCLAPVPSERPTYRYSPIFKVICWPMCRWPTYGKVLYSLSDLIFALLAYRITRHSQRVHHLWLMNPFVIALSVRGSFDSIVQTLVAWMLLTIKQHKYLMSGLLLGLCIHLRIYPIIFTPFLLLYALLDRKADQREPLDGIFRAGLLLCCTLISFFATTLISMLIDDGYLSSGLLYHVSGRVDHRHNLSILWAVQLACSKGKEVYCWPFAKLFQTVILAALIIQRVLALRTLEPIENEEAQSVLKRRYFYHQLLSDLDQACRAFVAFNSVVTAQYFSWTFATFTLSPNAVLNKTSYGKLATFVGSLGLSLCISGALEFSGKTKYLSLITLANTAAMGSLLFL
The following text describes a protein:
Function:
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Sequence:
MKPVVGVVVSNKMQKSVVVAVDHLFHHKMYNRYVKRTSKFMAHDEEDACNIGDRVRLDPSRPLSRHKHWVVAEILRRAKMYVPPSATASSENDTKARQAGVATK
The following text describes a protein:
Function:
Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.
Sequence:
MTDAPATPYAARTPVHEQHLDGFGTVRVLPLDPAADAAVVHGWVGEERAAFWGMNDLTRDQVAAVYAHMDTLDTHHAFLVVKDGEPAALLQTYDPAADRVSECYAAEPGDIGVHLLLAPAGAEGTRPGWTAALSGALMAYVLLGLDRTRIVVDPDVANEKAIARFLKQGFTAGPAVVLPEVDLPDVYLPEKKAQLAFLRREVAFGA
The following text describes a protein:
Function:
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Plays a role in the accumulation of some potyvirus during viral infection. Required for the accumulation of cucumber mosaic virus 3a protein and turnip crinkle virus p28 replication protein during viral infection. These proteins are necessary for cell-to-cell movement of the virus.
Miscellaneous:
MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice site.
Sequence:
MSYNQSRPDRSETQYRRTGRSTGNQQQQQQHRSSSAAGYGKGAGAPGSAPAPSTYPDNSSLSSNRSFKKPGNAQGGGQPRVNLPPVNHPNNHNNGPNAHSRSQVTGEPGVGGPTNPTESFNRNTGPIPKAPTSQSTVMSSKINETPNTAKVAASGDASQAFPLQFGSLGPDLMVPARTTSAPPNMDDQKRAQMQQSSLRTASNVPASVPKKDSSNKGADNQLMRKEGHNPSSEKADIQVPHIAPPSQTQKSPITNIRMPSVQTPYQHTQVPHPVHFGGPNMHMQTPVTATSFQMPMPMALSMGNTPQIPPQVFYQGHPPHPMHHQGMMHQAQGHGFATPMGAQIHPQLGHVGVGLSPQYPQQQGGKYGGARKTTPVKITHPDTHEELRLDRRGDPYSEGDSTALKPHSNPPPRSQPVSSFAPRPVNLVQPSYNSNTMIYPPVSVPLNNGPMSSAQAPRYHYPVIDGSQRVQLINQPAHTAPQLIRPAAPAHLSSDSTSSVKARNAQNVMSSALPVNAKVSVKPAGVSEKLGSPKDRSHGEVNISLSQKNVEACSLSSSQQPKPSFVSGVPNSSAPPAKSPVETVPLAKSSVETVPPVKSSVETAPVTTTEIRRAEMVSESISVEDQTCKVEPPHNLTENRGQTMPDSLVSDPETATVAAKENLSLPATNGFRKQLLKVSTTSDAPTSDSVDTSIDKSTEGSSHASSEISGSSPQEKDLKCDNRTASDKLDERSVISDAKHETLSGVLEKAQNEVDGATDVCPVSEKLAVTDDTSSDLPHSTHVLSSTVPLGHSETHKSAVETNTRRNTSTKGKKKIKEILQKADAAGTTSDLYMAYKGPEEKKESSNVVHDVSNQNLLPAIPQAVEAIVDTEPVKNEPEDWEDAADVSTPKLETADNSVNAKRGSSDEVSDNCINTEKKYSRDFLLKFADLCTALPEGFDVSPDIANALIVAYMGASHHEHDSYPTPGKVMDRQASGARLDRRPSNVAGDDRWTKNQGSLPAGYGGNVGFRPGQGGNSGVLRNPRMQGPIISRPMQPVGPMGGMGRNTPDLERWQRGSNFQQKGLFPSPHTPMQVMHKAERKYQVGTIADEEQAKQRQLKSILNKLTPQNFEKLFEQVKSVNIDNAVTLSGVISQIFDKALMEPTFCEMYADFCFHLSGALPDFNENGEKITFKRLLLNKCQEEFERGEKEEEEASRVAEEGQVEQTEEEREEKRLQVRRRMLGNIRLIGELYKKRMLTEKIMHACIQKLLGYNQDPHEENIEALCKLMSTIGVMIDHNKAKFQMDGYFEKMKMLSCKQELSSRVRFMLINAIDLRKNKWQERMKVEGPKKIEEVHRDAAQERQTQANRLSRGPSMNSSGRRGHMEFSSPRGGGGMLSPPAAQMGSYHGPPQGRGFSNQDIRFDDRPSYEPRMVPMPQRSVCEEPITLGPQGGLGQGMSIRRPAVASNTYQSDATQAGGGDSRRPAGGLNGFGSHRPASPVTHGRSSPQERGTAYVHREFASLSRASDLSPEVSSARQVLQGPSATVNSPRENALSEEQLENLSLSAIKEYYSARDENEIGMCMKDMNSPAYHPTMISLWVTDSFERKDKERDLLAKLLVNLVKSADNALNEVQLVKGFESVLKTLEDAVNDAPKAAEFLGRIFGKSVTEKVVTLTEIGRLIQEGGEEPGSLIEFGLGGDVLGSVLEMIKTEAGEETLVEIRRSSGLRIENFKPHAPNRSKILEKFT
The following text describes a protein:
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MAQDMTEKDIMKMEVEQLKKEVKTERAPVSTSLSEMKTYIESLTPEDPLIKGVPDDRNPFKEKGGCSIS
The following text describes a protein:
Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Sequence:
MANRPLPNDEDHPPSYVDTVKDDQSMVVPIAQPSSSEKEMQEVTPCSPTMDTVKEQSPQTVPMPMPMPMPMPMQGVDVGQSPLPPPILQQPGGAMPVPPPISQQPIAGPGGPDPATQSYFPQSLQWMQVPAPNTVSNDCSPGLERLFQLSQVIICPDIQQQELFMPMFRSKYQVKNNAGQLIYYAIEDNVTTAINMYGYDLAEIALYDSMERKVMQLSRALSGEVSGCLSAILYKLNVACPPENIIGSVVQTSIFGPKHAVTSPNGVTELAINGPGHCCAIRAAEGYLNFPIISKSGKVIGNVAKHLPNMGNLQCNMEVNCT
The following text describes a protein:
Function:
Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MNVLIYNGNGASKICLLRTFQSLLPFVVPLYAMRFVDASTLEKEPWPASTALLVMPGGRDMGYCSSFNETIYRKITDFVKRGGAYLGLCAGGYFGSAVVDFRMPDSDLNVVGKRKLQFFPGTCAGPTFPGFTYDSEDGARRASIIVDGMQSSPVHTHIYFNGGGSFLETENYSNVKVVARYQETDFEKSAAIIYVKVGKGNVVLTGIHPEFSAEGSPILDKRDEKTRLELLSYILKLLGLKVPKDTSKCGQPTLTDQYLFPNNVETKRFIEKALTNKVKNQDEDTLYTFQFSDISSEIPEHQLANLDISADLSDSDNEIVKIWYGDEEKICKKAKPSFDLELYAKLINGCRFGLPIIVAPVIRSTQTLLDKNYRFLDSTNTGFTVLGNYQTAGRGRGQNMWVSPYGTLAFSFIINVDAKNFSTTPIALFQYLMALAVVRGIREYAPGYENIPAFIKWPNDVYVRVDKGGINFQGKQYMKLSGIIVTSNYRKNVLHLVVGCGINVSNLGPTVSLNTLVDEWNKNSDNPRLEKFSFEKLLASVLNQFDRYHRLLLEEGFSLILPEYYQYWLHSNQTVNLASGGKAIIQGITSDFGFLLAQLLNENNEPTTKVVHLQPDGNSFDLMRNLITRKT
The following text describes a protein:
Function:
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MKSSSLENGTLANAGVYEDDLDSDEELVSEEEFENFNNEDSEDDEDSNNESKTAKSQLAEIPFDTLLNAQRDLLKEQQKTKIDRKNMKHTEKVDKKFLAKERNTPLKNCQVKNQFLVFAKFDSLSGNLSKDKVKKNYGFLNEYRVSEIQQLRDELKICKDQERAESIRQTLKSLLSKMERHLEEERAERVMHEFRAQEKERVKEGKKPFYLKRNEQKKLIQMDKYKSMEGTKALDKYIEKKRRRRAQKEKKHLPRARPSANSQNK
The following text describes a protein:
Function:
Inhibits the activity of the calcium ATPases ATP2A2/SERCA2 and ATP2A3/SERCA3 by decreasing their apparent affinity for Ca(2+).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MEVSQAASGTDGVRERRGSFEAGRRNQDEAPQSGMNGLPKHSYWLDLWLFILFDLALFVFVYLLP
The following text describes a protein:
Function:
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.
Sequence:
MNINIIDFLSNIFKENNNNNNNEINIEQNQSLVSSLFLLIPNLSKLQLLLDLESYLKTSTISTNNKFLVFLLSIGYNIIKYNNNNNSNEEVENKTVSIINFYINKFIIQNEDNNNCIDENEIKNITIIISKIQNLIFNKEIYSTCCQLINGISNINNNNNNSNKYGLFIVNNILNNENLSLSIIEKMSIEFYPTLIPVIIENLENSSIINQYTKQQSLSILSKILLDKNNVSIIENNQILKSLYQTNWLKLLWNAIVKQKDINERLKLCFFFHQCYFDCLLFNLKKKSNKQQKQQQQQQQQQQQEEGEEEVKQIEPIFNIIEKVEYWNILFESLIDKDSLPRKQAIHLLKNTVALPSMLWKNQLPKNWEQKQWNLFFSLYECFDETKSHLFIPVWVQIHNLSANVKLDDNFTQYSNPTSIYFWIRILYLRGFNHININIKKRVILDALADVSIVPYLNGYGIEFSEFQLPLLKALDAYELSNPYELERNKELGERLSTYFYHCIKSTSDLEVLLQFTSKSIQEIKTIIFFISTLSPLVSKLKLTPTTILFEQLRSILTCHPIQNDNNELYQQVSNFIKSLNISTTQQNLSFSQISKILSLLPNEMTNTKDFKNWLNSTNNNWFINNLIKSTNNLFKEEEEKEEKEQQKEIDNNIESYQIEKENLQGLSRILSICLDNEINDYIISTILPLLNLSSTKKKTRLLLFLNCILDELSQQQLLNCNIIEKLSPFKEILVNLVKEYIFLNNNNINNNQTILSKEDSEKIIDHFKTMESIIRIIKKFNNTNQKLFIEMQNLLLDSKSLDLKGITIVLLVWIQSRQYNGSEGCTIEEQEILIKKLLELEPRYKFDSTISFILPKSIQYKWTCIHSILYSNSSSSSSSTFSYDQEKTFDLAISALDNATGSVLIPIFECLSIVISANKKQDDTNLITSNEEYMNQLFKQSYLAFSDSNRKPNNLCVAFTNLLFNSVLFENPVTIPLIKEYLKQTLGDWGESARISCGLLSHCCGIWSKKTNTLPIFLNEIMDLCLLTSEDQLILEDDYENITEDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSLESKQLFNNHGYIIRWFVSQLESKECKPFVETLLLELLQLNFKGELSKREYSQQSRLNKIKCKLWRTLCSLTHIVSFTSGGESNDLYEKVSDLMWKTLELKNHGNVRYLIQLFIVNVLIKSPNIQITNQQLINRMELSINADYQISASLIIISSTFLYYLLNNYQDHYQDCVINLFKTILPWSTDFHHAVRTTSQLAIYSIINKKFKILQQFNDNQFILSLYNYLDTHKIQKRLREKQTLFIQNDDPLKKTLADNIFTTSSTIDSNNNNNDDADDGIEESEKQQQQQDDDYSNLSVLDDSVIPMSLLDISKRLIKDFQVSFQNNQIQQPIVPTSALSKSEEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSETIINSETSNIPSSTEEDILDFQRRITPWQWVNKLEEHHQISSGNSNSKNSKKSRQSIIVCGTLIENTPNIAGLIRTCEIFNVEEVAIPNNKLLSDPQFQRVSVSAEKWVPTIEVTKPNLLDYLKLKKKQGYSILGVEQTSQSKRLSSFQFPNKCLLLLGQEQNGIPAEYLSIIDYAVEIEQLGQIRSLNVHVSGSIVIWEYTQQQILKQQQQQ
The following text describes a protein:
Function:
Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A.
Subcellular Localization:
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MERVPPDPEKLLQPAPLEPLGGPGAVLEAAVGEETEGTREDVSGADTMTGNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHADGQSVLTDSLWRRYSEFELLRNYLLVYYPHVVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRVASHPVLCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTELRQYSDELQSVISHLLRIRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLETAAQDLASKKQQCEELATGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM
The following text describes a protein:
Function:
Protein covalently bound to the viral DNA that acts as a primer for viral genomic replication by DNA strand displacement. Assembles on the viral origin of replication in an initiation complex with viral polymerase, DBP, host NFIA and host POU2F1/OCT1. During initiation, the polymerase covalently couples the first dCTP with Ser-580 of pTP. The terminal protein stimulates the template activity over 20 fold compared to protein-free templates. Neo-synthesized viral genomes are linked to two preterminal proteins, one for each 5' end. These new genomes are encapsidated in the nucleus, and during capsid maturation by viral protease, preterminal protein is first cleaved into intermediary (iTP), then into mature TP. May play a role in host nuclear matrix localization of genomic DNA.
Subcellular Localization:
Host nucleus matrix.
Sequence:
MALSVNDCARLTGQSVPTMEHFLPLRNIWNRVRDFPRASTTAAGITWMSRYIYGYHRLMLEDLAPGAPATLRWPLYRQPPPHFLVGYQYLVRTCNDYVFDSRAYSRLRYTELSQPGHQTVNWSVMANCTYTINTGAYHRFVDMDDFQSTLTQVQQAILAERVVADLALLQPMRGFGVTRMGGRGRHLRPNSAAAAAIDARDAGQEEGEEEVPVERLMQDYYKDLRRCQNEAWGMADRLRIQQAGPKDMVLLSTIRRLKTAYFNYIISSTSARNNPDRRPLPPATVLSLPCDCDWLDAFLERFSDPVDADSLRSLGGGVPTQQLLRCIVSAVSLPHGSPPPTHNRDMTGGVFQLRPRENGRAVTETMRRRRGEMIERFVDRLPVRRRRRRVPPPPPPPEEEEGEALMEEEIEEEEEAPVAFEREVRDTVAELIRLLEEELTVSARNSQFFNFAVDFYEAMERLEALGDINESTLRRWVMYFFVAEHTATTLNYLFQRLRNYAVFARHVELNLAQVVMRARDAEGGVVYSRVWNEGGLNAFSQLMARISNDLAATVERAGRGDLQEEEIEQFMAEIAYQDNSGDVQEILRQAAVNDTEIDSVELSFRLKLTGPVVFTQRRQIQEINRRVVAFASNLRAQHQLLPARGADVPLPPLPAGPEPPLPPGARPRHRF
The following text describes a protein:
Function:
Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Endomembrane system.
Sequence:
MAPPPAPPQKSPSPSQPSGKSEVSDLKLQLRQLAGSRAPGADDSKRDLFKRVISYMTVGIDVSAAFSEMVMCSATSDIVLKKMCYLYVGNYARCHPDLALLTINFLQKDCHDEDPMIRGLALRSLCSLRVPNLVEYLVAPLGAGLKDGSSYVRMVAAVGVLKLYHISAATCLDSDFPAVLKSLMLTDPDAQVVANCLFVLQEIWNLEANKSEEASRERETLLSKKIVYYILNRIKEFNEWAQCLVLELVAKYIPSDTDDIFDIMNLLEDRLQHANGAVVLATIKVFLHLTMSMTDVHQQVYERIKAPLLTLVGSGSSEQSYAVLSHLHLLVMRAPMLFSSDYKHFYCQFSDPSYVKKLKLEMLTAIANESNTYEIVTELCEYAGNVDVPIARESIRAVGKIALQQYDVNAIVDRLLQFLEMEKDYVTAETLVLVKDLLRKYPQWSHDCIAVVGNISSKNVQEPKAKAALIWMLGEYSQDMPDAPYILESLIENWDEENAAEVRLHLLTAAMKCFFKRPPETQKALGAALAAGLADSHQDVHDRALFYYRLLQYDVSVAERVVNPPKQAVSVFADTQSSEIKDRIFDEFNSLSVVYQKPSYMFTDKEHREPFEFSEEIGNLSLGQEPVGNSPRYDESDKDLLLSTSEREENGGPSTNGPAASGYSAPTDYNSSLVSLSSQTQSETAISDPGMPKYTSQMTLAIDDLLGLSVSAAPAPPSLKLNPKAALDPGTFQRKWGQLAVSISQDCSVSPQGIAALTTPQALIRHMQASSIQCIASGGQSPNFKFFFFAQKLDGPPLFFLVECIVNTSSAKAQVKIKADDATASEAFFGLFQSALSKFGVL
The following text describes a protein:
Function:
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Subcellular Localization:
Cytoplasm.
Sequence:
MAKEDNIEMQGTVLDTLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVELTPYDLSKGRIVFRSR
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Subcellular Localization:
Nucleus.
Sequence:
MAAAATNGATMREAYPPPPSLFNLYRPDDGVSPLPPGPPPIPTPADVSALRERKVELKVLGNPLKLHEELVPPLTTAALYRPAGPDGHIDFKSELRRLSRELAFMLLELTKAVAEQPGSYASQLTHVNLLFANLVQLTNMLRPYQARATLEATLGLQLSNMRAALGRLRQQVAAADAALGGMARALVEAGEGDSAESAARPAEAGTAEAGAAGAEAGVAAGEGAGTEAAVAAARGADAGRTAAPDAMEEF