lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.
Subcellular Localization:
Nucleus.
Sequence:
MSGKQKTLFQTWGNNQPPETRKAKETKPRKGKTSAVGRGKQSVPRGVLHRPPVPVRQQPSTCQQEVEDDDDDVLLVAVYEAEKTLNQSGILNAEGLQSKDKQNAHSVQGNHSVQGNHSVQGKLWDELGKTSSPAVLGLPGIACQIQGNQRGNNTAINSDCRTFGTSRNVPTTNQDMESKDEAKATDIENLPGFDLSAGSVWIYPTNYPIRDYQFNISYTALLQNTLVCLPTGLGKTFIAAVVMYNFYRWYPSGKIVFMAPTKPLVAQQIEACFRVMGIPQDHMAEMTGSTQAQNRKDMWEKHRVFFLTPQVMVNDLTRGACPASEIKCLVIDEAHKALGNHAYCQVVRELTNYTNQFRILALSATPGGDTKSVQQVVSNLLISQIELRSEDSPDIQPYSHERQLEKFVVPLGEELESVQKTYLQVLETFAGRLLKNNVLSRRDIPNLTKYQIILSRDQFRKNPPANVIGAQQGVIEGDFALCISLYHGYELLLQMGTRSLYSYLHGIMDGSKGMTRARNELSRNGDFMELYQQLENMFSDLNVTEGNGSLLFNTSLRADAKKPFVYSHPKLKKLEDVVIQHFKSWNKNGDQNTSNQIPGDTRIMIFSSFRDSVQEIAEMLNQHHPTVRVMTFVGHSSAGKGVKGFTQKEQLEVVKRFREGGFNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLVQRMGRTGRKRQGRIVVILCQGREERTYNQSQSNKRSIYKAILGNNKMLHLNPQSPRMVPEGLNPKVHKMFITQGNYEAKESIRPKHKDRRSSTKHCNSSLFLNASADTLKEEWDLTHAEFETWNRLYRLQESDGIMDVRLPKSQFEYFRDAEPNKERPSGNIHKLSLTEWRVWQNRPFPTDSVDHSDRCKNFIHVMEMIELMRLEEGDCNYDLEMMSYLNKEDVDPTATNTRAINVLDNNSKVAEKSTHPKKGKTYKNTPLSLVLEPDEDFMSSCKKITKSHSTDFVAVDSKVHAQGTEEGGSTELERVVGLNEDDHGKESVFSANVTKYKDSRSNAVTSNQSDSDHMLLISDTEDAVAKSQSNVDAKADSGYHSFNEDPSSNLSNLFYTPQSFINHGVFTEFVDNKICELKKMLLHIKRFLSHSPPPINELDCLDDFQKYENFSHHSCLSDPVKDKTQEDLLLQPLTQQPLTPVPVTINSKEMQAELNHKKQTDRVAGTLLPATEVKKDDVLFGEDRLKPRDVIQTVGGKAACSEKNVGFYSEDSSKPSSSKDLHDVRTENDDHWDELFDYESQDKENENFTFQVNMPVLEGGDTEGSSAENENHNIDSVPTFLEDSFDLFEEDGFSDNANYGQLHSKHESTDKPHENAKTTVTFNMFDPSSLLQEQVQTEDEPETKDDIWSQENLEELDCSEELYSVNFDLGFSIEDDELSESDGKNETPSKDSKDDELSEIDSKNETPSKDSKDDNLSDSKNVTPSKDFKVPNPLKRNDMNAIGGNAVSTPVVSSNICSTFSEVAEKQIHLFSPLEPVRGKISLTPEKSLCSSSFFTPIGEKFRSPQTPLGNLCDSEAGELQSSKAGEKSIHSTTNFSVHDGRVVQAERRQTNSCSEHSLIESSPESEDDVVICRKRKLTKANVLMSPQTASSDCDFDSPIPTAKKRRHVLKTPDSDEEEEEDNFKSTHSTARDKSAGHSRKSYQHRAIAVSKKRKRCKQRARQFLDEEAELSSEGAEFVSSDEDMNSDNEQDTSLVEFLNDDPQLSQALNDSEMHGVYLKSVRSPAFGGRFKMAPQRRRHNMSVFSQIPEQDESYMEDSFCVQEEDDEEEADNLGSSEEEVEINFDLLKDVSIVGGKKQYCTRRRLKLKEAQSRQRNDTHPVKKKTRLIIQDDSSEEEETEAKSRLKDTSPPQKTLPSSKPSLGNTSCQNQSAPTLINNELDIPLRDRCQARINIKASISDELDFQPESKCSSGSKSRTLSEVVHSKGKEEVSIGRVNFDLTMDSSAVANLSFPGTVGVSALAGIRTLCILADSREISSGPEVISYLKMSLGVKVEVCSLGGCDYIVSSRLAVERKSQSEFANSANRSKLVDRIQHLQHLFDRVCLIIEKDRIKQGETSRTFQRTRYYDSTLSALISAGVQVLFSSSQEETAGLLKELGLLEQRKNTGIDVPTEVKGHKQEVMQFYLSIPNISYITALNLCQRFDSIRQMANSSVQVISARAHVSAQKAEELYRYVHYMFEAEMVASENPAKRSRVS
The following text describes a protein:
Function:
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence:
MNKLIIAIIFCLALFSSAFADIWSNCGTSADLLQIDTVDITPNPPQKGQDLTVSASGYLSQTVQDGTANIIVKYGFITLYKGSQDICTPKDPIACPIQAGQYNKTVSATIPSAAPSGKYTGSVTLVSNTGAQIACIDVNFTL
The following text describes a protein:
Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Sequence:
EQTNLIADFSKPYCLPLIERGKHSDLKAITHQTLVDVLRGGYSEVVGRYTIVDCRYPYEYEGGHIKGAINLYTKQAVINELMYNSNEYLSRERNKRSIIIFHCEFSSERGPKMNRYLRNRDREANGDNYPQLVYPEIYLLEHGYKEFFQHHRCHCTPASYVPMLDERY
The following text describes a protein:
Function:
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Sequence:
MAEVRSRGLIGLLRHAISTAMNRPDAALPNHFELLATDGTARTGRLTTPHGVVRTPAFMPVGTAGAMKGMHWREVRDAGADIVLGNTYHLMLRPGAERIAALGGLQRFTGWSGPMLTDSGGFQVMSLADLRKVSEHAVTFRSHIDGAKVELSPERSIEVQRFLGSDIAMQMDECVRLPAEHADIERAMQLSLRWAERSKRAFESAPDGYMLFGIVQGGDVPQLRHASAEGLVAIGFHGYAIGGLAVGEPQAVMLAMIDETAPMLPKERPRYLMGVGTPDDILEAVKRGIDMFDCVMPTRNGRHGVAFTRFGQVNLRNARHADDPRPLDEESTWPSTRSYARAYLHHLVKAGETLGAMLLSEINIAYYQSLMQGIRDAIAHGTFDEFYQRTREDWARGDIAPRQGD
The following text describes a protein:
Function:
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Subcellular Localization:
Apical cell membrane. Basolateral cell membrane. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane raft. Membrane, caveola. Membrane, coated pit. Postsynaptic density. Presynaptic cell membrane.
Sequence:
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
The following text describes a protein:
Function:
Auxiliary protein of DNA polymerase delta and is involved in the control of DNA replication by increasing the polymerase processibility during elongation of the leading strand. Involved in DNA damage response (By similarity).
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=During early-to mid replicating trophozoite stages, colocalizes with ORC1 and ORC5 to distinct nuclear foci which probably are DNA replication origin sites. Dissociates from ORC1 and ORC5 during the late schizont stage.
Sequence:
MLEAKLNNASILKKLFECIKDLVNDANVDADESGLKLQALDGNHVSLVSLHLLDSGFSHYRCDRERVLGVNIASLNKVFKLCGANESVVISSKDDEDNLNFVFENNKEDKVTNFSLKLMSIELDSLNIPDCEEGFDAEVELSSKELTNIFRNLSEFSDTVFIEIDSNCIKFTTKGIVGDAEVALKPRDSTSEDDIGVTIKSKKKIKQSFAIKYLNLFSKSNILADVVVLGLSDSRPIEFKYEIKDTSPDSDTLKIGFVKFFLAPKMDDDMDNKD
The following text describes a protein:
Function:
Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.
Subcellular Localization:
Cell junction, adherens junction. Cell junction, tight junction. Cytoplasm, cell cortex. Lateral cell membrane; Peripheral membrane protein.
Sequence:
MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKSREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRRSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFSELKTTFDKLETETHWVPVSWLHS
The following text describes a protein:
Function:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MLVAAGLPELSPSSAHMLWLRLAVFLHVVWQLTSAEGHRRQGRRDRGSDQEEACKYTNQEDLNSFLWTIQRNPPSYFFGTIHVPYTRVWDFIPSNSKQAFHQSNHVFVELDLTDPYTVSALSSCQMLPEGKSLGDVLPEDIYRRLKQHLKYIKNMMPLWVTADQRGRGLYADYLFNAITGNWERKRPVWVMLMVNSLTEVDVRTRGIPVLDLFLAQEAARLNKRTGAVEKVEEQCMPLNGLNISQVLFALNQTLWQQENIRSGQLPVSFSTDDLIHHYNCGDLNTIIFDHHTAQVPNLLNTTLSPPDLEQAQQIDEYFRTELILLRNQRMAGRVSKLLQDHPNDSFFFAFGAGHFIGNNTVIDLLRRNGLDIAYVPSNGTLNTSNSDQSATPPTFPSLRTRLTSLLCPDNNGKPRNCRRRRKKRRRIHRENERPRQFNDLWIRIEESDSPSTSTASPTEVPPRSLHSLHRVSSRRSASPQCTQSWWLLIVVTLAAMPGPLLLVMR
The following text describes a protein:
Function:
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. Represses hmp expression under conditions of elevated intracellular iron concentrations, in the absence of nitric oxide.
Sequence:
MQLTSFTDYGLRALIYMASLPDGRMTSISEVTEVYGVSRNHMVKIINQLSRAGFVTAVRGKNGGIRLGKPANTICIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLKELDNYTLADLVEENQPLYKLLLVE
The following text describes a protein:
Function:
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Miscellaneous:
MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Chromosome.
Domain:
The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of smc6, forming a V-shaped heterodimer.
Sequence:
MTSLIDLGRYVERTHHGEDTEPRSKRVKIAKPDLSSFQPGSIIKIRLQDFVTYTLTEFNLSPSLNMIIGPNGSGKSTFVCAVCLGLAGKPEYIGRSKKVEDFIKNGQDVSKIEITLKNSPNVTDIEYIDARDETIKITRIITRSKRRSDYLINDYQVSESVVKTLVAQLNIQLDNLCQFLSQERVEEFARLKSVKLLVETIRSIDASLLDVLDELRELQGNEQSLQKDLDFKKAKIVHLRQESDKLRKSVESLRDFQNKKGEIELHSQLLPYVKVKDHKEKLNIYKEEYERAKANLRAILKDKKPFANTKKTLENQVEELTEKCSLKTDEFLKAKEKINEIFEKLNTIRDEVIKKKNQNEYYRGRTKKLQATIISTKEDFLRSQEILAQTHLPEKSVFEDIDIKRKEIINKEGEIRDLISEIDAKANAINHEMRSIQRQAESKTKSLTTTDKIGILNQDQDLKEVRDAVLMVREHPEMKDKILEPPIMTVSAINAQFAAYLAQCVDYNTSKALTVVDSDSYKLFANPILDKFKVNLRELSSADTTPPVPAETVRDLGFEGYLSDFITGDKRVMKMLCQTSKIHTIPVSRRELTPAQIKKLITPRPNGKILFKRIIHGNRLVDIKQSAYGSKQVFPTDVSIKQTNFYQGSIMSNEQKIRIENEIINLKNEYNDRKSTLDALSNQKSGYRHELSELASKNDDINREAHQLNEIRKKYTMRKSTIETLREKLDQLKREARKDVSQKIKDIDDQIQQLLLKQRHLLSKMASSMKSLKNCQKELISTQILQFEAQNMDVSMNDVIGFFNEREADLKSQYEDKKKFVKEMRDTPEFQSWMREIRSYDQDTKEKLNKVAEKYEEEGNFNLSFVQDVLDKLESEIAMVNHDESAVTILDQVTAELRELEHTVPQQSKDLETIKAKLKEDHAVLEPKLDDIVSKISARFARLFNNVGSAGAVRLEKPKDYAEWKIEIMVKFRDNAPLKKLDSHTQSGGERAVSTVLYMIALQEFTSAPFRVVDEINQGMDSRNERIVHKAMVENACAENTSQYFLITPKLLTGLHYHEKMRIHCVMAGSWIPNPSEDPKMIHFGETSNYSFD
The following text describes a protein:
Function:
Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Subcellular Localization:
Nucleus.
Sequence:
MSGKTFGQKQNFSFSKFACLFELGGTATHRHPTNELNGLNDWRNGPRISCFRDLVRKRIAGICELEANYQWKELGSNFVNLLENQLFMEAASEEEYMNQDVLRWRLQDLIQRVMVGLNCSPELPSYTAPCKVMPTLGLAHGYNSDAADSPSNHLNQNICGSNSMVAGRNQLRFLKELLDNKDSHMRQISNDMLLSPEMSSVITTFSERGSTITASSNGDGFSEVEAFNGGPFFTKQDYQHSFEVASKDSCQQQYLAQGVANNENLPARDFVSTFREGSEFTDSVLHIPEHASQVISEDSMFSSMGFSRMNPEAQILEQKQWQPYLSHEQFNKPFHLDEPMYYLAQQGEFSSPIAGQAVSMHSQLPSEQLHGIHVASESFSLLSNSKEIAGPKHDSFECKILHAYSSHKNSAMPTGDCLVSFVNYLHSTFCKDRSCKCRHFCALLSHFDKCCYANCDICGPLRDHPLTHNHHQNGSFLGDSSKTNTGGSGSCSSENMLPPTKRFKPSSYCSENSLPFSGHLKVNKSSSLLSSDKRTSVLAPLTVQPSDPEGLLPLLQWPESPVSINSEVLEGNTEFSTRPMQSPSRFYQKGNSAGEQFLSPNAESLCRPSKELIVAPKSEEIDSRSFGGTVDSVRDKADQLRVNSMPALFEEPGTSSKEEVIQIASNCDLAKPDLEAEMNEEMKAENPKTRGVSLIEFFSADEIKDHISSLRQWIGQRISKEEKEEQEIHCANENTCQLCAADKLLLAPVPIYCSSCGSRIKRSVIYYNASEENGTRHSFCTLCYKARGASITFYGITIPKAKLDKKKNDEEIEEPWVQCDKCKSWQHQICALFNDKRDMEGESEYICPKCCLEEIRRWGHMPLPKSTVLGAKDLPSTLLSDFIEQRLFRRLQQEKEDKAKVIGKNIDEVPGAENLVVRVVLSVKKQLKVKKQFLEIFRDGNYPDEFSYSSKVILLFQKIEGVDVCLFGMYVQEFGSECSQPNHRCVYISYLDSVKYFRPERQTATGEALRTFVYHEILIGYLEYCKKQGFAACYLWACPPLKGEDYILYSHPAIQKTPKSDKLRQWYNSMLRKAAKENVVVNVTNLYDHLFVPSGQFHSKVTAARLPYFDGDYWSGAAETIINNIEQQNGKSSGRKIKKSMTKRTLKAMGHTNPSDDITKEVLLMQKLGQTIFPVKEDFFVLHLQFVCTSCHEVISYGQRWFCSQCKNFQLCERCHDLEHSLNGGDTHAISSKEKHLLSKIMVDDIPSDTKDEDVILDSWLFENRHTLLGFCQKNHHQFDTLRRAKHSSMMILHHLHNPIMSTTATTCNICQQDINAEDRXXFISWLISLLLLIVRLRIEMHGGDYSRTTNGEPCSYPNCLLVRRLLYHASNCTIRIRRGCPGCIKAWKILWIHAKFCRQADCCVPRCRSGKLTISNRFEESYACTVTGDSLGGLLGSQAPKIFSG
The following text describes a protein:
Function:
ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
Sequence:
MAEIIVVTSGKGGVGKTTTSASLACGLARRGKKVAVIDFDVGLRNLDLIMGCERRVVYDFVNVVHGEATLKQSLIKDKRFDNLYVLAASQTRDKDALTQEGVEKVLKDLAADGFEYIVCDSPAGIEKGAFLAMYFADRAVVVVNPEVSSVRDSDRIIGLLDSKTRKAEEGKNVPAFLLLTRYSPGRVEGGEMLSITDVEEVLGLKAIGVIPESGDVLNASNKGEPVILDGESPAGQAYDDAVARIMGEERPMRFISVEKKGFFSKLFGG
The following text describes a protein:
Function:
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome (By similarity).
Sequence:
MLGKGGKRKFDEHEDGLEGKIVSPSDGPSRVSYTLQRQTIFNISLMKLYNHRPLTEPSLQKTVLINNMLRRIQEELKQEGSLRPAFTPSSQPSNSLSDSYQEAPPPAPHPCDLGSTTPLEACLTPASLLEDDNDDTFCTLQAVHPAAPTRLSSAALPAEKDSFSSALDEIEELCPTSTSTEAAHTAAPEGPKGTSSESSVQKPEGPEEGRTDDSRFMDSLPGNFEITTSTGFLTDLTLDDILFADIDTSMYDFDPCTSASGTASKMAPVSADDLLKTLAPYSNQPVAPSQPFKMDLTELDHIMEVLVGS
The following text describes a protein:
Function:
Aromatic peroxidase that oxidizes aryl alcohols into the corresponding aldehydes and then into the corresponding benzoic acids. Oxidizes toluene and naphthalene. Catalyzes the regioselective peroxide-dependent hydroxylation of propranolol and diclofenac to 5-hydroxypropranolol and 4'-hydroxydiclofenac. Catalyzes the regioselective peroxide-dependent hydroxylation of naphthalene to 1-naphthol or 2-naphthol via a naphthalene 1,2-oxide intermediate. Catalyzes the regioselective peroxide-dependent oxidation of pyridine to pyridine N-oxide. Halogenates monochlorodimedone and phenol. Oxidizes the sulfur-containing heterocycle dibenzothiophene to yield ring-hydroxylation products and to a lesser extent sulfoxidation products.
Sequence:
MKYFPLFPTLVFAARVVAFPAYASLAGLSQQELDAIIPTLEAREPGLPPGPLENSSAKLVNDEAHPWKPLRPGDIRGPCPGLNTLASHGYLPRNGVATPVQIINAVQEGLNFDNQAAVFATYAAHLVDGNLITDLLSIGRKTRLTGPDPPPPASVGGLNEHGTFEGDASMTRGDAFFGNNHDFNETLFEQLVDYSNRFGGGKYNLTVAGELRFKRIQDSIATNPNFSFVDFRFFTAYGETTFPANLFVDGRRDDGQLDMDAARSFFQFSRMPDDFFRAPSPRSGTGVEVVIQAHPMQPGRNVGKINSYTVDPTSSDFSTPCLMYEKFVNITVKSLYPNPTVQLRKALNTNLDFFFQGVAAGCTQVFPYGRD
The following text describes a protein:
Function:
Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-74'.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Localizes mainly in the cytoplasm.
Sequence:
MGKNTKRNKKTKQQQQQPQQNGVTASASGTAVEDFEDQQAASSLPSLNGKKRSQLNKLVEELLDLVEKQPANPNEEWKQYGQLQELLKQIMILEEPLSQAVCPQISDSPDDQTRLAKVEAFSAWAKDGGVHSEGLEIAIFPGYQLGLRATRPLAKDELVLSVPRKLILSEENNSDCRLFGKMTQATHLNLAYDLVIEKIRGEFSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAFLYKYAHTMTEPSTGNRSHPGERGLFFTQHGLCYKLYRWAVSTVMTRQNLVPSEKQESEDGPKLISALIPYWDMANHRPGKITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVDPNNTKDYVNIRVGLSLTDALAAKRASILDKLNIRHTAELRVLPAPDFISKELLAFVRVFKMSAEQLDHWCSDLDRAGDLLHIDCALETDHETRTWQFLEDRLKLLLAVFNKEMHEADEVKELELKDGQEIELMLFLYRRLERSILAGALQYAQEHRKV
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLSHSQKVVRLYRKAIKSIRDYSEDYDMFLLNAGDLRASLKAGKNETNPFAIQQMVKQLEDFNSYWEHPDPYIPCDGINGTKWQRNTAPAKYAVDPTNHLLENGRE
The following text describes a protein:
Function:
Suppressor of bem1/bud5.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAGSLSSAIFNVLKYSGMASLAVTLIALGFLYKYQKTLVYPSAFPQGSRENVPTPKEFNMEYERIELRTRDKVTLDSYLMLQSESPESRPTLLYFHANAGNMGHRLPIARVFYSALNMNVFIISYRGYGKSTGSPSEAGLKIDSQTALEYLMEHPICSKTKIVVYGQSIGGAVAIALTAKNQDRISALILENTFTSIKDMIPTVFPYGGSIISRFCTEIWSSQDEIRKIKKLPVLFLSGEKDEIVPPPQMVLLFGLCGSAKKKFHSFPKCTHNDTCLGDGYFQVIADFLAENDINTPAS
The following text describes a protein:
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular Localization:
Chromosome, centromere, kinetochore. Nucleus.
Sequence:
MSHLMPRRTSEFRGDVLEERGTADKRQTRATKRSAATHTPSSSQAAPRRPSASRLPQPLNLERDRASQMGVTPKRGHRFVPSTAERAIAPHSDKKWVAERAQQILEYLHGIQNSEAPTGLIADLFSRPGGLRHMTIKQFVSILNFMFHHIWRNRVTVGQNHVEDITSAMQKLQYPYQVNKSWLVSPTTQHSFGHVIVLLDFLMDFLPPLPSSDVVEEEFPFMETMEQPSSYLNSMHCESTTIMSTTQAHAIQLDEDVNGLLFEEASKCIALWDQELTNEEAKLQAETRDQVISKKCDLPDRKALDQLIGDLKTKLQQLENKLHDPSEDNKLNKLERLTKEHDQLAQQLAASEEELIKKLKLYEQLSAQVEEKQSNLRQQMKYEKRLEQAVNRQKFSAQQLKELQMKCDDMENYSKAYERQVKEVSELELHQQVMLSRAKQKQLDSVEVFNSHVRHLSMDPVICGLIKSGIGQQSDLTLPLNPNQEDISERVQCLELLGKLLQQHRQQNIDRRQMLDKQVAKVKSDSIELDTEIATMDSQLRAQKQRLTKMEASYRTKRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEKLEASKQRNEDLLTAAEQFQEQDLKARQDRLEKCEQKLAKAEDQLLAVESKVNATQAKLNEVEQKVYSAKLPSFQPVLDAIKNH
The following text describes a protein:
Function:
Acts as a magnesium transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MSIEPTPPNLENDGIENDVERVSADFDRVHSLCEILEPAFEQIENGTPLEDAPLRDKLTELTVLLSELHPADVAAVLESLPPRERNIVWILVKPEDDGEVLLEVSDAVRETLIESMDKDELLAAVDDLDADELAELADDLPHQVVYEALQTRDEEERAQVKAAMSYEDNQVGAIMDFELVSIRADVACEVVLRYLRRFDSLPDHTDKIFVVDENDVLQGVLPIRKLLVADPEDLVENVMAKDVVRFRAEDDVEEAAQAFERYDLVTAPVVDENKKLIGRITIDEMVDVIREESEADMLNMAGLQEEEDLFAPVWDSVKNRWMWLAVNLCTAFLASRVIGAFEGSIEKIVALAALMPIVAGIGGNSGNQTITMIVRAMAMGQLTDMQAGRLLKKEVGVALVNGIIWGTVMGAVSWLLYGSLGIGLVMIAAMTLNLLLAATVGVLIPVVMEKFGRDPALGSSVLITAVTDSGGFLIFLGLATLFLL
The following text describes a protein:
Function:
Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MGAAEEQLKELGEKLEAAPPDPADDLAKLLEQAAECLHGVEQSPGPSVMETIQPCLKAVARDEFLKHHDEDVKVLLATCFCEITRITAPEAPYSDDVLRDMFHLIVDTFSGLNDVNGKSFGRRVAILETVARYRACVVMLDLECNDLIADMFRSFLEIISDNHEPNIVNSMQSVMALIIDESEDIEESLLNVLLSTLGRKKTGVSLPARKLARHVIEHSAGKLEPYIRKILTSSLDGDGTSTNNSIDHHEVIFDLYQCAPKVLKVVVPYITGELLADEVETRSKAVEILGELFSLPGIPILESFKSLFDEFLKRLTDRAVEIRVSVIEHLKKCLMSNHSRPEAQEIIKALCDRLLDYEENVRKQVVAAICDVACHSLGAVPVETIKQVAERVRDKSVSVKCYTMERLADIYKFYCQSGSDSSVNSDDFEWIPGKILRCLYDKDFRPESIESILCGSLFPPEYPTKERVKHWVTAVTHFDKVEMKALEQIFLQKQRLQQEMLKYMSLRQTSQEDTPDMKKKILGCFRSMSRLFNDHTKSEEYLNMLHQIKDANIWNIFTSLLDCSTTFNEAWSLRVDLLTKLGEKHALHDFVSTLSMRCSYLLVNKEYVKEILSEASDQKSTGNTKLMSSCMDLLTAVSSFFPSLLSGLEEDIIELLKEDNELLKEGIAHVLSKAGGNIREQLASSSSITLLLERLCLEGTRKQAKYSVHALAAITKDDGLMSLSVLYKRLVDLLEEKKVHLPSILQSLGCIAQIAMPIFETRGEEIINFITKKILDCNDDSGDVSAHKSEWSDSTQSCLLKIYGIKTLVKSCQPCKDAQAHPGIEKLMGILKNILTYGDISANMISSTIDKAHLRLAAAKAVLRLSRQWDHKVPVDVFYLTLRISQDDVPQVRKLFLSKVHQYIKERALDAKYACAFLLAMDDYHAPQYEEFKHNIIEVAQICQQVKMRQLSVQAETNVLTAYPEYMISYLVHALSHDPSCPNIEEHEDVEAFGPIYWRLHLLLLILLGEEGLQHSVPGMKKESFTTIVSIFKSIKYSQDVVDVNKTKTLHAICDLGILIGKKLCQEQINISEAQTVSLPSQLYAPVQKDQNENSVESDEQIWPGCENVLAHFEALMTAKSAEVESPKDKMLIDETDEFGNEVPLGKIVKILKSQGAKKAGRKQKTKSGSINMEKDDDVLGLVREINLDNQENLGESEKSKPKKKRMDAKESNDKPVDFSTPKRKRSVSKSRPHSTKGNKYSDELLLQSVDPDETINSFENKVEGAKKRDDSVDTELVTSPASVKTPVSKGKKGAKKPHAEILSSSPKKSDEAGSSKRTVDSGSLNGSIKRQKPKLVSGLAKCTTHDTGSEDLIGKRIKVWWPLDKKFYEGVVESFDSSKRRHTVLYDDGDVEVLNLAKEKWEIVASDDPPVKARKKDHSGRNQGRAQDKSITSSKQTPPPEQEKSKKRPSPPKRKGKPKGLPKNKRRKIGGKSSVDAAGDANIDSDSSSSLAHSDSDNDKKSDGRNEKEVVVAKKAKAEKVSGKGDEPKEEEPDDHNLNSKEESDNETLSVWKKRTAKAT
The following text describes a protein:
Function:
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton.
Sequence:
MSSTKSDFEIIREYIIGDGKDISVGKAPEGNVRLEITHSVLTGESLGTNNFKNFSLDLKIKDFKEKLYRFVGTEPKYMELILRDENKVNDICKIDDDDDKTLGSYEPKDGMNVHIIDKDPNNFVSELQDISKAPKPVISEEDYNKREGTYKKWKEENQLKKENDTTATTVTATTTTTNNATDTEIEIKVGDRCKVISDDPTNYDERLGKVQYVGTVEFSSGVWIGVELDLPLGKNDGSVKGKQYFQCSPKYGCFAKPKNVLVGDYPEEEI
The following text describes a protein:
Function:
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MDLVVACSVIGAALAIGLATLGAAIGQGIAVSRATEIIGKNPNAKKEVMGGLFLGLLMIVALMLFALAIAVILLWVNPFI