lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSSIGSGYDDSCTTFSPDGKVFQIDYATKAVENSATALSIKCIDGVVFGVEKLIISKMIEKSSNKRIFNVGTHVGITCAGFLPDARKLVKKANEEAESFKENYGMNIPVKVLAEKIAMYMQNHTLYGSLRPFGCSLLIGGVDQHGYSLHYIEPSGTTYGYFANGIGKGKQICKNELEKINFSQITCEEALVKLVEIIDLCHGEWKDKPYEIELSWISEKTNNIVKKVDKEMKQKIIDQVRNKQIHEN
The following text describes a protein:
Function:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Subcellular Localization:
Nucleus matrix. Nucleus speckle. Nucleus, nucleoplasm.
Sequence:
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAGLLGNAFDGHQLLRPLIFCQDHLREGPPIGRGDSQGEELEPQLPSSLSSIPYGFCDHCWTKDVDDPPLVTHPSPGSRDGHMTQAWPVKVVSPLATVIGHVMQASLLAL
The following text describes a protein:
Function:
Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion.
Subcellular Localization:
Postsynaptic cell membrane; Single-pass membrane protein. Postsynaptic density.
Sequence:
MIWYVAALVASVLGARGLSVQGALGSREEPEFVTARAGESVILGCDVIHPLTGQPPPYVVEWFKFGVPIPIFIKFGFYPPHVDPGYAGRASLHDKASLRIEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTVNAPPTFTETPPQYVEAKEGSSITLTCMAFGNPKPIVTWLREGELLAAGPKYQVSDGSLTVLSVSREDRGAYTCRAYSIQGEAVHTTRLLVQGPPFIVSPPENITVNISQDALFTCQAEAYPGNLTYLWYWEEENVYFKNDLKLRVRILIDGTLIIFRVKPEDAGKYTCIPSNSLGRSPSASAYLTVQYPARVVNMPPIIYIPIGIHGYIRCPVEAEPPVTLVKWNKDGRPLRIEKYSGWNLLEDGSIRIEEATEDALGTYTCVPYNALGTMGQSPPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPIIAWRKVGKPSRSKHNTLPGGTLQIRSLGKDDHGEWECIATNVVASITASTHLTVVGTSPHAPTSVHVVVAMTSANVSWEPGYDGGYEQTFSVWYGPLMKRAQFGPHDWLSLPVPAGSSWLLVDTLEPETAYQFSVLAQNKLGTSSFSEVVTVNTLAFPVTTPEPLVLVTPPRCLTANRTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEILDDAILGTESEFFAKDLSQDTWYEFRVLAVMQDLISEPSNVAGVSSTDVFPQPDLTDEGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRPPSESSDDQGPQAKRMLSPTKEKELSLYKKTKRAISSKKYSVSKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKTRRIEGFPFVEETDMYPEFRQSDEENDDPVVPASVTALKAQLTPLSSSQESYLQPPAYSPRFHRALEGPGALQATGQARPPAPRAFHHQFYGYLSSSSPGEVDPPPFYMPEVSPLSSVMSSPPLHPEGPFGHPTIPEENGENASNSTLPLAQTPTGGRSPEPWGLPFGSLEASPATTFPPQLQQCEAAAEGSQPTGCLPRGPPPSSLQVVPASYPGILPLEAPKSWTGKSPSRGQPSVPTTTKWQDKPMQPMGCQGQLRHTSQGMGIPVLPYHEPSEPVSHSGTSTFSLDTRWYEPQPRPRPSPRQVRRAEPSLHQVVLQPSRLSPLTQSPLSSRNSSPELTARARPRPGLIQQAEVSEITLQPPAAVSFSRKSTPSTGSPAPSSRGESPSYRPATAFTSLTTGFSGSQGSSLPADTMDVFGDIPSPRRASEEILRPEPTSTTVATSGKRPSPSWDAAAPERLEALKYQRIKKPKKSSKGSSKSRKQSNGSASQVQHPPSSQVLWPDEAVCLRKKKRHPRQDPFARLSALKDDLCHRQLPEDQTAILNSVDHDDPSGHATLL
The following text describes a protein:
Function:
Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
Subcellular Localization:
Periplasm.
Sequence:
MLRLNLRFLSFLLCIIQSVELQAAPSVPTFLTENGLTYCTHASGFSFNPQTADAGTSMNVVTEQIYNKLFDIKNHSATLTPMLAQSYSISADGKEILLNLRHGVKFHQTPWFTPTRDFNAEDVVFSINRVLGGHNTYLPTLAETNVTYSNPQYRVFHEQARKVRFPYFDSIKLNEKIKSVTALSPYQVKIELFAPDSSILSHLASQYAIIFSQEYAYQLSADDNLAQLDTHPVGTGPYQVKDYVYNQYVRLVRNENYWKKEAKIEHIIVDLSTDRSGRLVKFFNNECQIASYPEVSQIGLLKNDDKHYYMQSTDGMNLAYLAFNFDKPLMRDHEIRAAISQSLNRARIIHSIYHNTATVANNIIPEVSWASSVNTPEFEFDYNPKIAKNKLADKNLLLNLWVINEEQVYNPAPFKIAEMIKWDLAQAGVKVKVRAVTRPFLTAQLRNQSENYDLILSGWLAGNLDPDGFMRPILSCGTKNELTNLSNWCNEEFDQFMDRAITTSHLSSRAKAYNEAQELVLRELPIIPIANVKRILVANSRVKGVKMTPFGSLDFSTLYFIQEKY
The following text describes a protein:
Function:
Important in cellular regulation.
Miscellaneous:
MISCELLANEOUS: Present with 7500 molecules/cell in log phase SD medium.
Sequence:
MPKESEVINSEFHVDVQDPERLNGHPVAKFINKLSGQPESYVNRTNYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITSKRVETSNILPDVKKGFSLRKKLRDAIEIVKLNNRIKRLRNMYSLGDDGDNDIEENSLNESLLDGVTHSLDDLRLQSQKKGGELTEEQMKLKSALTKDAFVQIVKAATKNKHKVLAGEEEDDSKKTLHDDRESKSED
The following text describes a protein:
Function:
Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSRRNNKPTKGHPSKHEQERKRDERATKAAYRRERKAKSYLEDDENFAGFANQLAVMGLKIRDIPGDGNCLFRALNDQLEGHSNNHLQHRREVVEYIIQHRQDFEPFVEDDVPFDRHVSELRKHGTYAGNDAIVAFARLHGVNVVIHQLNKPLFHVKGSDRRDAPELHISYHNGDHYCSVRRIADNSDRPANVKIAPGAGEERGRHKQNDLQTNRHNYHTDYPIISDYGGDFTAEELSYLSEDRTDMEEFVMNSTGCQDLRLIRETLEDHHYDLESTVDFITQIMFLNIGENAPDMPKKIARSPSSDYNINQRTANSHLWSEDGTANRVFGGTGTVRSTSSHSSSGGSDSSRGAGGGARAKVHTQQKQAQTKLRRGQARLEKKKRQEERHRQRVVGNKQQEEQNDDDAKTVLVKDMSLLSI
The following text describes a protein:
Function:
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subcellular Localization:
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Sequence:
MASGKAAGKTDAPAPVIKLGGPKPPKVGSSGNASWFQAIKAKKLNTPPPKFEGSGVPDNENIKPSQQHGYWRRQARFKPGKGGRKPVPDAWYFYYTGTGPAADLNWGDTQDGIVWVAAKGADTKSRSNQGTRDPDKFDQYPLRFSDGGPDGNFRWDFIPLNRGRSGRSTAASSAAASRAPSREGSRGRRSDSGDDLIARAAKIIQDQQKKGSRITKAKADEMAHRRYCKRTIPPNYRVDQVFGPRTKGKEGNFGDDKMNEEGIKDGRVTAMLNLVPSSHACLFGSRVTPKLQLDGLHLRFEFTTVVPCDDPQFDNYVKICDQCVDGVGTRPKDDEPKPKSRSSSRPATRGNSPAPRQQRPKKEKKLKKQDDEADKALTSDEERNNAQLEFYDEPKVINWGDAALGENEL
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Sequence:
MIRIQYAKEKERNDNIFPSDRVSQISPPEMSLSKMKSLFVIPSSRVKCLDFHPTKPIILAALYTGEAIIVDALRGSIIRTYSVHQGIPLRACRWIPKTGDFVTGGDNRSLNFYSQVKGKQTLEIPDAHDHYIRSLAVHPNEMLLLSSSDDLSIKLWDISKGCTAIRTFQVHTGIVMDVKWNPRDLTTFASCSLDGNVIFWDMGSEQPRFTQRVSNKCVNSISFAVNGDRSLIATGSDDTIVTIIDLQSRSVVTTLEGHDNNVTRVEFHPTRPLIITTAEDNSTIIWSSITFRKENRLSSALERGWALGFSNCPPLMAIGHDKGLTIHKFKNLGTPMSLDPTGKLIIAQGAEVSVAVLKNMPDFVDGSEITLPLKEGITSDQTPVHLHHSPNGRYITVCGENEWTIYTTLGFRSRAYGNGISFIWCSNSTSFAALNTNRLITVYKSFDDSQVLNVFALKIWGGELIGALVNNGLEFYDWEDLQLVRRIEVHPSEVLWYGNYVAIRTKTNIVVLSYNSEYQSEFVQGSGYEDSFDVVYDVDGKASSICWANGILLFTDGQKVNRISAGIVLPTASFKNTVDLIGYLPREGVVLVADQMRTLLGVHLPPNLLDFESAVAADEEADPELVDEDYRARTAKFLKQLGKNELALLVSNDTAMRFDLAIELGELETASQCASDQTMWRRLARAAIGKGEMKLAEKALFECGDLSTLLVLYKSQNRKSDIENLVTKAKEIGQLNVAFTAALAVGMFEECVDILIASEKYAQAAIFARTRCPKMMSKAVQEWKKHTPNERISGAIADPADFPSLFDEIEPEESVQA
The following text describes a protein:
Function:
Probable alcohol acetyltransferase; part of the crm gene cluster that mediates the biosynthesis of a yet unidentified copper-responsive metabolite. In contrast to crmA, is not involved in the biosynthesis of fumivalines or fumicicolins.
Sequence:
MSKGKLEQVSAACHHLGFFNNAGLSAHYKLSESSSPAVADLRGLVYAAAGDLLRKHRILFAIPVNEGTPNPHFACLPWIDLRRSIAFLERSVPLASAAEEQDKELDAILEEQHNIDFQTDYGTLPFWRLIILRSKGRNDFTASFIYHHAIGDGVSGLAFHKAFCNALEAASSSTLPTDRAENIIRPDENTVVLPPLEELHPMPISPRQPPLPTASPKEWTGASIHLPCKSRWASLYISPSASNAFVQECKEMKLSVTSALSSVVAAVLFDNLPSRVEALTCIIPVSVRPWLKLPPQVIDNAIGTYFDALRVRLTRAEQRSQDPSPVGIWCGARQVSRSINAYLCDVSPSGEPYTSVAAFKTVPDVSAVFRSTLGKPRDAAFEVTNVGLFPPAAIRRPSRWKAGNVLLSRSAAVPGAAVTVSVVTGRDGTMALGFSWQEGVVEDGFMHRVRQGVWKYFEKYQS
The following text describes a protein:
Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Subcellular Localization:
Cytoplasm.
Sequence:
MSLRVLNPNAEVLNKSAALHMNINAAKGLQDVLKTNLGPKGTIKMLVGGAGDLKLTKDGNTLLKEMQIQNPTAIMIARTAVAQDDTSGDGTTSTVLFIGELMKQSERCIDEGTHPRFLVDGFDVAKRACLDFLDKFKTPVVTGEEPDRDTLKMVARTTLRTKLYEGLADQLTDIVVNAVLCIRKPDEPIDLFMVEIMHMRHKFDVDTRLVEGLVLDHGSRHPDMKRRAENCYILTCNVSLEYEKSEINAGFFYSNAEQREKMVAAERRQVDERVKQIIELKNKVCAGGDKNFVVINQKGIDPPSLDLLARAGIIALRRAKRRNMERLVLACGGEAVNSVDELTEDCLGWAGLVYEHVLGEEKYTFVENVKNPRSCTILIKGPNDHTIAQIKDAVRDGLRSVKNTVEDEAVVLGAGAFEVAAKKHLIDNVKKTVKGRAQLGVEAFAEALLVIPKTLAENSGLDTQDVIVSLQNEHDRGLVVGLNHHSGDPIDPQMEGIFDNYSVKRQIINSGPIIASQLLLVDEVIRAGRNMRKPT
The following text describes a protein:
Function:
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
Subcellular Localization:
Cytoplasm.
Sequence:
MDSLPEEFFIRDLPVEEQAKEETRTKVEESTDQLDKQEKETPTDLVPVNLLLEVKKLLNAINTLPKGVVPHIKKFLREDFSFQTMQREVAANTQNGEEIVPALTLRFLITQLEAALRNIQATNYTAHQIDIGYYLTLLFLYGVALTERGKKEDYIEAENKFLVMKMVIQENEICENFMSLVYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDTDDHWFDIDPTEDEDLPTTFKDLLNNFIKTTEGNIMKQTICSYLDCERSCEADILKNSNYKGFFQLMCSKSCCVYFHKICWKKFKNLKYPGENDQSFSGKKCLKEGCTGDMVRMLQCEVPGIVKILFEVVRKDEYITIENLGASYKKLMSLKITDTDIRPKISLKFSTKDEMPIFKLDYNYFYHLLHIIIVSGTDIVRQIFDEAMPPPLLKKELLIHKNVLEPYYNHLWTNHPLGGAWHLLYPPNKELPQSKQFDLYLLLALIKHLNVFPAPKKGWNMEPPSSDLSKSADILRLCKYRDILLSEILMNGLTESQFNSIWKKVSDILLRLGMKQEDIDTVKENPIENLSLDYHQLSIYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIEIEELQNEEEELSPPLMEYNINVKSNPEIQLAEINKDGASIPSESSTESIKDLQEVKSKPKKKKKTKNKKNKESKEEQVPNMIGKEEQLKKEQANLYPVGKFVKDDASDIQEDSATEDKFYSLDELHILDMIEQGSTSNVTTEYGETEKEKLARQQQLCKLHYQCEDFKRQLKTVTFRWQENQMQIKKKDKIIASLNQQVAFGINKVSKLQRQSHAKDNEIKNLKEQLSTKRSQWEMEKHNLESTIKTYLNKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLSQLARVTNMAASNLESLQLKAAVDSWNAIVTDVRNKIAFLRTQYNEQINKVKQGFTLSTLPPIQLPPPPPSPEILMQQFLGKPIVKESLFRPLLTVPQIPAICSGVISTTGQPRHPLMAGIAWTVPASVGEAMSPSAGLGSDLPIINWEKITDRLKTAFPQQTRKELTDFLRKLKNTHGKSLSGLTFDEIVCKISQFIYPKRSQSQGKSVPNGNSVSPSHHTPPQANAVQPSKPARKPLSSQGPVKLEGANNLDDDKEEEEEPCVICHENLSPDNLSVLPCAHKFHSQCIRPWLMQQGTCPTCRLHVLLPEEFPGHPRRHLPKI
The following text describes a protein:
Function:
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.
Subcellular Localization:
Cell membrane. Membrane; Multi-pass membrane protein.
Sequence:
MSNCSSRALTLLSSVFGACGLLLVGIAVSTDYWLHMEEGIVLQQNQTTEVKMALHAGLWRVCFVAGQEKGRCVASEFFHGPDTDIVTENTANILKTIRSATPFPMVSLFLVFTAFVISNIGHIRPQRTILAFVSGIFFILSGLSLIVGLVLYISSINDEVMNRPSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQFLHPEVWHRGRSPSDISSDVSIQMTQNYPPAIKYPDHIHISTSPC
The following text describes a protein:
Function:
Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4-phospho-L-aspartate.
Subcellular Localization:
Cytoplasm.
Sequence:
MALIVQKFGGTSVGSVERIEQVADKVKKFRDAGDDLVVVLSAMSGETNRLIDLAKAISGDQQPLPRELDVIVSTGEQVTIALLAMALNKRGVPAVSYTGSQVRILTDSAHTKARILQIDDQKIRTDLKAGRVVVVAGFQGVDEQGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVSVAQRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFKEGPGTLITIDEEESMEQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISGANIEVDMIVQNVSHDNTTDFTFTVHRNEYDAAERILQNTAKEIGAREVVGDTKIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDAPARQGE
The following text describes a protein:
Function:
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MATLHPEDAAGRPVRRRPRPSSSGGSRSPSTKRHSIVREHLGEELNVPDGQEMDLGQVNKNLNAAYAKAEKDSDDEKEKKEEGVVDELPEKYSYPRFSKNNRRYRFTDIKFKPTPSILDKFAHKDSEFFGFYTLLWMVFAFCVFRTGLLNYTNEGILFRGQIFAILSKDLWKVALVDLGMYLTTYLSVFLQLAVKHGLVDWNSFGWIIQNVHQTLFLFFYLWVAKSSNLPWIGNIFIVLHAFVMLMKQHSYAFYNGYLWTVEDELSHAKQRLTEDIPVSEKEDLKLDIEFCETELKVQSRHTPFPTNITFSNYFWYSMFPTLVYEIEFPRTPRIKWTYVLEKVAAVFGVFFLMIWVAESYLYPPVVAVIQMRDEPFWNKVRIYPIFLSDILLPFVIEYMLVFYIIWDAILNGIAELTRFADRDFYGPWWNCTSWEQFSREWNIPVYQFLKRHVYHSSISAFKFSKGAATLTTFLLSSLVHELVMFAIFKKFRGYLLLLQMTQLPLAMLQKTKWIQDRPVFGNAFFWFSLMIGPSLMCSMYLLF
The following text describes a protein:
Function:
Required for the migration of axonal growth-cones and distal tip cells (DTC) along the dorsal-ventral axis of the body wall. Acts cell nonautonomously and independently of the classical daf-4, sma-6 or daf-1 TGFbeta receptor signaling. During axon migration, facilitates long-range repulsive guidance of unc-6/netrin by enhancing unc-5-unc-40 signaling at the expense of unc-5 alone signaling, probably through direct interaction with receptor unc-5. Involved in cell-cell contact formation in sensory rays in the developing male tail, via a pathway involving plx-2 and mab-20/semaphorin-2A.
Subcellular Localization:
Secreted, extracellular space.
Sequence:
MRRLPIVLLLSVFSIANCAKVDVDLINETIRDLLHFKSSDPNVTSFHRSSHTLTEHMKNLYENFIDEDSNEDGNLVRAIEPAVGKFEGQEVLVFDVEGFDSHESIMRAELHFYLRRRDSFARRRSRQIRAKSVCVNEYCRQQTLKKIRVGGDENLEEYKVIWDATKSVFDSYHLDAKQAVFRITREHSKMRPYAEMIRKSTPFLVIYSKVNHTLDTVSVMKQTEQTKRKRRDLGNEELREYYNYNSIPLDNDDREPIKRKNGKKNSLSEEISSEDVWQGFGEETSREERERIANEELANDVRVVLLQNKNRCHKEGVLVSLKHFGWDRYVIEPKTIETSFCKGKCAKPMLTSGKASNHAMLQSLFAAEPVCCAPTNLKSLNFWYRDEKGRTVIRNYSKMLIGSCSCL
The following text describes a protein:
Function:
Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.
Subcellular Localization:
Nucleus.
Sequence:
MAKKKLNSTIKRSRTRSGCVTCRDRHIKCDEQQPVCKNCQKSNRKCYRGIRLNFTQYTFYNPDDNKPKELQQNEQPNSSHYAFPNLEPNPVSQKHRILDQSITIASLYDDLKKYKPYIHLHTPEDLRESDLQFQEDTYNSYISTSAINLRGKKLTKRDPGLSTSLSVINPTLESEIKPNPVILNQLSFHPPPNLNTGVLYPPTATAATTTTSSPTNHHLHPYFVSSIPNPQHHPMLDTSQHQETTSTDPNQFDYSHLSMPQSTPLLMKYDITTYVRLIETEKYYMLLDLANELDIWKKIIPSLCLQISENDSFLLDCLMSCSRNTSVNLLDLTNEQLNKWSQLKNAPVISERIQQFEHILISIVLILLGLYLNTTKVRLTDYHKVIFNNQAKLFSHVLRKIHTFITSNKPNSAVLTNAIQSITMLKFFIDKNYDFSYEFKNIQKGRVTDTSEEITYSNSNLYSNPDISYISTFNEYEIIYLNNSYQNLVHVDQSNSMSMGESQLYKDLLWYLMKVDFVINYPEAANNLVLDHNVVYQQITNASTDLSFSNNLNYLNPRSYANYFLKEFIIKVLSMGSNAIIEDANNRINTLFNFIDQSYMDPELKSQFHHCFTWTVRYIHPVSD
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MASQQMSTNNAQMSAQQAAVLQQTQAQQLSQQQDFDPVHRFKMLIPPLKDSLQNVMTIASLNFAHNTAIDNGLKTTEKGNDAAVQRFDKSLEEFYALCDQLELCLRLAHECLSQSIDSTKHSPNLVPTATKPDTVQTESLSYSQYLSMIKSQISCAKDIHNALLECSKKIAGKGQGACN
The following text describes a protein:
Function:
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved brain development.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Colocalizes with USP7 in the nucleus.
Domain:
The AXH domain is required for interaction with CIC.
Sequence:
MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGSRGHGGGRHGPAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPPGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLGRAAGLVNPGSPPPTQQNQYIHISSSPQSSGRATSPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKTSSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLETQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGAQPPVIGYLSSQQQAITYAGGLPQHLVIPGTQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAASPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASALLKHAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLTKIEPSKPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
The following text describes a protein:
Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Subcellular Localization:
Nucleus.
Sequence:
MKCLCEKDSAHSTPHHIFGCPSWGTSSESQVQQTSMSKGLSFKVEALPQECHNSKALSFQFQEQDSSSTQSTGSSQSGQIPFQHCSSTGSTFKRTEENNMGCLIGSSSIGSPNLTVHPPLMDHSQSLAHVALHYADPGYNGLLSASYGQQYKLQAYSIMSSNSDQLLQGQLMETASVRIPLPSDMAEEPIYVNSKQYHAIMRRRQCRAKLEAHNKLIKDRKPYLHESRHVHALKRARGAGGRFLNAKKLQESKLDSPNHGQNVSTGYTCLNLNGNMSEPKMHDQVENYRDDASDVAYGSNRNEMFQQQQELEFRLCSYPSSQTGRNMQDYTSDKNVGANQRRLSVRM
The following text describes a protein:
Function:
May have a role in maturation, such as during flavor formation or other metabolite production specific to aging tissues.
Sequence:
MEDSTLQVVIMALSSFALATFLFYKILRRRRPTSTPPSPPALPVIGHLHLLTDMPHHTFTRLSQKLGPIIYLQLGQVPTVIISSPQLAELILKTHDHIFSSRPQLIAAQYLSFGCSDVTFSRYGPYWRQARKICVTELLSSKRVNSFHYIRDEEINRMLRVISTHSDGELDMSSIFFAVANDILCRVAFGKRFIDGLKEKKEKDLVSVLTETQALLAGFCVGDFFPNWEWINSVSGMKRRLMRNLKDLRRVCEEIIEEHVKRRNECCGDLGKEDFVDVLLRVQKRDDLEVPITDDNLKALVLDMFVAGTDTTSATLEWTMTQLARHPSVLERAKDEVRKIAGNKGKVKESDLQHLHYMKAVIKETMRLHPPVPLLVPRESMDKCTIDDYEIPAKTRILINTYAIGRDPESWTCPLEYNPERFMDKDIDFRGQDFRFLPFGGGRRGCPGYALGLATIELSLARLLYHFDWKLPPGIAAQDVDLSEIFGLATRKRVALKLVPTINKLYASGEEDNLQFATL
The following text describes a protein:
Function:
Component of the mechanistic target of rapamycin complex 2 (mTORC2), which regulates multiple cellular processes to control cell growth in response to environmental signals. In response to signals, TORC2 phosphorylates AGC protein kinase family members, such as gad8. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Within the mTORC2 complex, sin1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by tor1.
Domain:
The CRIM domain forms a ubiquitin-like fold with a characteristic acidic loop, which recognizes and binds AGC protein kinase family members substrates.
Sequence:
MELTREKVLLLTFLRMQYSHILPDSIENRVISTEAPEWELDKSLQDLLIHDYDYSKTSFSSSPPIVANDTVSNVRKPSDTKQVNGAGGQVNHSRAEDSDYATSDLSESSDVGDDDNSCIFSFSKVPMQKDVASIKEEERLDPKISTLNNIDAIANLKLTNMVESSQAVNLTSSKQSSINQQSSVSTDYDDLRSISEESFHLSQGEIPLTFPMNSSLTDTEADAVVAVDALFPGKQRGTHNTVNKARSVSNAKAPTSALRALLEHKENSSQNGPLAENFATFSGHAESNALRLNIYFPSSESPSKPLFVELRKNVLVSEAIGYILLQYVNQQLVPPIEDEAQNPNYWNLRIVEDDGELDEDFPALDRVGPLSKFGFDAFALVKATPAQIKENQAAYPFKSKHPTSIPEANNKTHIRHTSSTSSQSQKQAQDVKDTLNTSHVVQVRLPPYGDNARFCNIEISKTTRLAMVLNQVCWMKQLERFKYTLRVAGSDTVLPLDKTFSSLDGNPTLELVKKKVRDKKGSTQQLPTSSPQNSVYGSIKKDAQSSTYNATDIMSSNTYQEFLVWKRQPVSFMGRHERLLAIDGEYVHIMPSESKNIFETPKTSSIHAGSIILCKQSKKSPCNFKMIVSKNRETKRYDFEVLSALEAAIIVSRIRALMNTVKKIN
The following text describes a protein:
Function:
Integral thylakoid membrane protein that plays a crucial role in thylakoid membrane biogenesis and thylakoid formation in early chloroplast development. Is essential for de novo synthesis of photosystem II (PSII) core proteins and required for efficient insertion of thylakoid membrane proteins, presumably via interaction with ALB3. May assist synthesis of thylakoid membrane proteins at the membrane insertion step.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Sequence:
MSLASVIHHGILPPAKSDRIFLTIPVFPPDFRARGWTKSPFSLLINPSLASAANRRLSHLPPIACSRGIDQEDEEKESRELLPHKNDENATTSRSSSSVDSGGLKDYQQEETYKTSFKTVALCVGTAVAFGIGIGLKEGVGKASEFFAGYILEQSLSVDNLFVFVLVFKYFKVPLMYQNKVLTYGIAGAIVFRFTLILLGTATLQKFEAVNLLLAAVLLYSSFKLFASEEDDTDLSDNFIVKTCQRFIPVTSSYDGNRFFTKHDGILKATPLLLTVAVIELSDIAFAVDSIPAVFGVTRDPFIVLTSNLFAILGLRSLYTLISEGMDELEYLQPSIAVVLGFIGVKMILDFFGFHISTEASLGVVALSLSTGVLLSLTNKSSDS
The following text describes a protein:
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Sequence:
MDFPANRFSGLIPATFSAVVNSSCPLLGFIGRLSPVTGAASAAAIIIVTVALPGFLYLKNNKNKLPDERHNVRGESTHAPTFDPLLNEFVGGRISEIDVYFDAEYAEELQLHEVLVASLYTGQSSNHASVSAQGLLSETEMLNLDKEDEDQLNNFCEICLDDKEGWEMFKNYSCSHSFCYECTGKHIMARISEKAKVIGCPGISCGAALDVNACRFLIPEEARIQWDESVCQSMILDSQKLYCPFRDCSALLVNDSGESIERNKCPLCKRSFCAVCRVPWHSEFTCKEFLKLNAKKRGKGEEMVKILAKKKNWQKCPNCKVFVERTEGCIHMTCRCEHEFCYKCGAKWTAAHYCRKK
The following text describes a protein:
Function:
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence:
MSFVFNVLKFLVCLMRGCRSRGKDEDFWGLVPSFIHASNVALYVTYVEVEEKVKLFRSFWWSDSDIGLLFRLQPYCFNKSEGDIRIQLEFRVVWLFSNGMKESEQCHVTLQINATEEASLMELLKFMYSNNLTVTAAYDVLDVLLTAEKFDVASCTRYCGRLLRTLTMTPESVLVYLDLPSTILMTEAFQPLTIATKQFYVVYFKDMTKYDKDEILNLPLAGLEEIIASDDLRLLSENEVYRFVLKWVASQYPKLEDSRKIMMTRLAKFIRYPYMTRRMLTDLLTREEFDPEFAEKVVTEALSFKSAVPNKQHAYISDENSNVNRRFVERPYKVRPIKMVKFQQPRPHCVVYLELKRDICASLFPSGNLISEPFEFGGQEFFLMALHHMDHFEVYLATVHGPCAFPFDYEFAGTDSIHAQEFVSRFKRSYTCEELFSPILLFKIPWTCFMGEDKKVLYFINDRFHLSVELTDKR
The following text describes a protein:
Function:
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Sequence:
MGWSVAWHLRQALPAAARITVVAPEEWNQYKSTVLSAGGLRQQFSIPANVEFSLFGLDFFRNFANLDRQQRARTTLQPDHALQDLLHIKMRENGYTFLASTPESAQTLAELVEMQCRLGAATQLATPTQLRARYPWLCVDDIEAGTMSYSGEGFIDPWEYLANLRALCLQTGGIDQRQGRVDRLELDARRTSVAGAWISSPTVDADPAYEPVDLFINCAGCFSNDVFKGTHLSVPVRARKRYVFAIRSSAQNAPGINSPLLVDPSGVYFRPELAPNTYITGVSPKADADPDYSDFSTLAELEDSLFHDQIWPALYNRVPDAFDALRVISSWAGFYDYNTFDQNALIGLMPGMDNLYVCTGFSGHGLQHSPAAGYVISQLVTGQGHKLGSEAFAVERVAANAPILEAGIV