lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus.
Sequence:
MAAAPAKEVTTKQVAAVRFGFYSEDEVRKLSVVNITCPLIFDDAKVPVKDGLYDPRMGPTDSRDKCGTCLLSHDRCPGHFGRIELPVPVYNPLVFKVMYKLLRCTCLHCHRFKLSQDTVDTYLRKLTRLVDGDLVKAVEISTERHVKSKELAELMAGGDSDDTEPKPDSSSKAAAGGKPGQAGAGGKGHAARRNITQHTLEAMQDTISELLGKMNSNKCQNCKVTNPQIKKQGTTKLFCVWSSRKALLDNAKEGFNIVNVLERGRDDVVGDLERGLQAEMKTKADSRKRARDAKAEADGEGGGAKMAPHTGAYGSAEDYMDVDDKKRAKRDTDGANADLNELSDDDDDEEDEEEGSEDLHAGEPGAPAEEAGTSGRGAGGGKGGKGKDGKAPAHLDVATKYMTPTEVEEHLRLLWSHEWPILSLIYSAQVSAKPGQRGGAGGRLLNEAEARAAYKMFFLRCLPVAPNKFRPPSKVGDELYEHAHNVILAKIINSSLELSSGPRAVDAAARTQGGTGADPAQAAAMDLSRRVATWLALQNHVCALMDSTTAEDLDKSGAQGIRQQLEKKEGLFRKNMMGKRVNFAARSVISPDPYIGAGEIGVPPYFAKRLSFPERVTPFNVERLRAAVIAGAHQHPGAVAVEDVTTGRMIQLGNLPLERRQAVAKQLMSSTAVLGRTGPISTRLGRASTGRPGAGGGAGAAALPSNYIVYRHLQDGDLMLTNRQPTLHKPGLMAHRARVLKGERTIRMHYANCSTFNADFDGDEINLHLPQDQLGRSEGYVIVHADQQYIVPTDGKPIRGLIQDHVVAATLITKRGTYFTADEYRQLVYIACTPWVGKGPAAAAAAAAAEATGKARPKVTVTAAGSSFDIDLEPPCTLKPRQLWSGKQVVSTVISFFTRGLPPLSFSAGGKVPASYWGAGSGEDEMQFHRGALVRGVVDKNAFGKYGLVHAVQELYGNTTAGKLLSAFSRLFTYYLQWHGFTCGMDDLLLVPGSEARRAALLATAEARAVQASSELLVDKDKKGAKGSAGEGLPAELLADPASHARQLLHYEIKVSAELGERYRTNRDTGKAHDMKGSGAMHALSSEVIKVCLPGGQAKAFPQNCLSLMTITGAKGSLVNFSQISCLLGQQELEGRRPPRMASGKTLPCFRPYDGGGRSNGFIGDRFLTGLRPQEYYFHCMAGREGLVDTAVKTSRSGYLQRCLVKNLESLRVHYDGTVRDNCDASIVQFAYGEDGLDVMSVSYMRQFGFLARNADRFSQLVDRKDALAASATAGLTAHEAEVAAALEARSKLLAEADAAAAAGKKDKAAAAKARAAGLLGGLPITALHPPTVLGAASEAFADALRAYVAANPDGALQAQDAGAKKDGKKDRKKDKELVAAGGRHGGKGSVDGPLFGQLMMLKYMRSLAAAGEAVGVLAAQSVGEPSTQMTLNTFHMAGRGEANVTLGIPRLREILMTAAPRIKTPVMTLPLVAGLGVPEAQVLANRMRRLRLAECLSGITVEEQPVARCVGLPEGFGRVYRVTLAFFKPAQYPPEAKLSFDELVASFQGLFSKRLKHEVEKEAKRKAGVGIGKVDVSTVQDSETAPAATGNEDGDGEAGGTERTKKKSEKADDFEDAEPDEELREGKLRFRGGRGEAATYDAGDDEDEEAAAAARRQAARRGLGDADEEDAGKAETAQDADDAAADDGAAADGGAAASSADIDYKNHTCSLTITLPLSSPKLLMLEIVERVAAITLVRSTPNIEKVYVVEGTGKDASVKLQTDGVNFEGAWEHSDIADVNGITTNDVHAMLVTYGVEAARATIMREVQSVFSAYGIGVDPRHLSLIADFMTHQGGYRACNRIGIESSVSPFLKMSFETAAHFLTDATLRGSVDDLKSPAARLCVGRVVELGTGCVELVQQIGGLAPGH
The following text describes a protein:
Function:
Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.
Sequence:
MTKSSIFQKYCEKAIGTLTEEDVEKFKSTTRDEERIRMLYGVAQAVPITPINNGKDLKQAQEAKISGNKLFAAKKYEEALHAYNEGIVVCPQDTDDGRELLTILISNRSAVFFEQEHFRKVFDDIDYVIAVGNYPPKLHYKIWLRKAKCYDALQNEKYAEETYNLAISSLKHAELDEKSREKKIAEIQESRKKKRKACPDKNQIIPISNADLFANGNREYVAAHKNVYFDFDPILGRFARALEDFDTGVIIVEETPHCAVISQENALMNCQFCCISTQQPVACRNCGHAVFCSLNCERQANLTFHKYECKAQPVLFHAGASINCAMALRMISQKPHGFFQQKKKLLKDFLKDNCKKVPIKSQIYRSDDYNAAFFLCRNEHLRKKGELVHYSVMAIYLLRLLKFSGYFGGNIKDDVVTEEEVFIASLILRHLQILQFNSHEISELRNLNEEMVTNGIQCHYKSEYIGAGLYPTLALFNHSCDPSIVRYNIGNRMIVRTIKPIKAGEIIYENYGPLYTSMDADERRVTLQNRYWFECYCTPCQQEWPLFEYMDPNQIKIGCQKENCPFEFTLYKDDLCPYFQCDYCDGVTKIFPSLKGLSQLAIMLPKAEDLYSAGETREAMKLFMQSLDILYKYSRPPCPDMIKVQQRLKTLFVHLGNKQYNYVQKL
The following text describes a protein:
Function:
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression (By similarity).
Sequence:
MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPSSEVADEPPTLTKEEPVPLETQVVEEEEDSGAPPLKRFCVDQPTVPQTASES
The following text describes a protein:
Function:
In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MASEGQSEDAEHPAEPPTAPLGSNSTFRWGDILAAVKDQLPSLDSDTSTSDCESDGELFIFQREQPNLIPDLSDELLEFSLEDSDMQKKEKKKWNGDLKSLGHQEKTDGAQVIAKEYVQVIKDEASNLSSHTEEIPSQKEAVVEESLADSTDGLEEEEPGRQQAREKRNSCRNTSLLLEELCSKKERRKLIETKILSKIFLEPSPGHPELNNKPPSRGISKSLERSAKEETSAAGHLQELTCLSLQCTENWDLDKTSMELKQQKNTHNDHAENFFSEDYETFRSRSEKQLMEKLEELCNRQSRTLSSRCRWPSAKISFHEEQENKKDVAFLSSSPSSLRMDAVRLQCLPEPPTVYVDLRDAEPQKSVTFPDEKQSAGDSSTDEDETMTVMDQEERKIRKNCSGKCLLLQQLRRARKEASELLHKASAPAERLKGIKQDPESLEEMDAFKVSQNQNFKMREGTNEVISRKLVRLEPEKRNTSLSSQRDNGADIETKSVMKAEKVQHLGNASESPLPTKEFPRTEESNRELSQKEEQMKEKHVRCGFQEQLERLQPQQSVSGKQLMAEKTPVLFHTETSYLPVVDRLPGRDSVRDEELLMAVWLSSSGRVPTDESSGPMRSVALRAADIYRALVTWLLSLVPPVKMKGGPKTPFQAVGLQQTWQEDGLALSACLMPTDESPTQDLMLIQEKLKMIKTKEDLQETSICYQRISDFLSCAWLPDVAWWRAELCSCFQNHLYPLLPETPSALLSYIATVNPDTQAVEKVLAMPSGFYWQTVGTDEKYLPNGSDIKACRHTDTEVAMVLLFETLSQRSLAPHHMLQLVLSSGLDTCGLHLLCSQRDALLSSSEKLPSSYASDTDKVLALGVRGPKGISTLQNITGPSDPQLAGMTDCSSINAIYCMSHGEPPVYLPQQDSCVHRELCLWFGGRAADAALHGGILDPTSRCNRTRPQSPSSTRTETDEEKVHLQGMVQSRPPAMLVSPTNEDIILTVSPLVSPRVYGNVISICTCRGFALQGIRQLQLSHKQAIVLSMTTSQIAVFCPGKISSLPENSPARGELSAESRERCLVLLLRKEDASHRILALVKGLMNELAKQNLLGNGQSSLPATAGLDPSMCFHVAPYTENLLQMLGGSFSVVPDPCNIPLDFFCNRIFASDPEMEQVVLLTVVGMDAINSAGELLCQILLPGSNNQSQNAEGPDLGFELLGLKWLPHLTRRQAKEITPFEVGDASWQRSLDTLMSNPVLVCALRRINAFQVLEDALKRLTPCRELSESDSALQRVMALTPEVTFRQAILFFTEKDLVADPEHRPTAKYLPPPGKTSRAGVEETQRCRAESLFAYLHAGAQILCTVLLIKPGAWSHHLARILRKLDLEKFTVVGMKHVHLEPDIALGLLSLEAKQDPAVLQAHRTYLTSGTSLVLCLQRPNAVKKLMDMLGPEDPKVAQALNPCLWRAQYGIDAVQNGFYGSESYQISVRDMKLFFPEGLCCAECQTLEEEEIYNLKCDPIVSVEINKQCKIIKHETGGQLDLPGSGQPRDLDRPVLSNLSQTTCLILPAIILRGSDPPYVELLDQLIGQGFTVTGVRLTVLDAPQAHCISEILSRAKCGVAAKCSLLMDGLCLVVAAERDNAVIGFDSLLDSVRWQKQSVLDMAQHLLYPQNEKQAEELLCCLFDSLTSDSTCHIESQSC
The following text describes a protein:
Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA.
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein.
Sequence:
MSHPQSGCVFCAAPLLPASRFGIFPKLESSFRFACRALAAQSEERLCAFKDPYQQDHGISESRISQENGTILCMKGSTCYGLWEKTREGDIHLVKQGCWSHIGDPQECHFEECIVTTTPSLIQNGTYRFCCCSTDLCNVNFTENFPPPDPTDTTPYNSSHSFHRDETIVIVLASVSVLAVLIAALFFGYRMLAGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFVNERNIYRIPLMEHDNIARFIVGDERFTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSITRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHHRRVSKIRPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSTTPLTSGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEIPYSDETNLHTTNVMQPGGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQASNGQACLIPDVPSAQVYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGGKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRTHSINSHAGTTQYANGAVPSGQTASSVAQRAQEMLQNQFSGEDSRLNINSSPDEHEPLLRREQQVGHDEGVLDRLVDRRERQLDNGRTNVNNNNSNPCPVQDTATLSIQNVARNPGQTQTRRAQRPNSLDLSATNSLDSSSMQLGDSSQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTEPLHCEVNNNGGDRAVHSKSSTAVYLAEGGTATTMVSKDAGVNCL
The following text describes a protein:
Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (By similarity). Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3.
Subcellular Localization:
Nucleus speckle.
Sequence:
MSRGSIEIPLRDTDEVIELDFDQLPEGDEVISILKQEHTQLHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKNKDNKKDLITQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPATQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLSKVGDKMRFDLALAASEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPVSKKKKRRKGSGSEQEGEEEEGGERKKKRRRRPPKGEEGSEEEETENGPKPKKRRPPRAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSDSDDDERPNRRASSESDSDDNQNKSGSEAGSPRRSGRQESDEDSDSDQPSRKRRRSGSEQSDNESVQSGRSPSGASENENDSRPASPSAESDHESEQGSDNEGSGQGSGNESEPEGSNNEASDRGSEHGSDDSD
The following text describes a protein:
Function:
B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5.
Subcellular Localization:
Nucleus.
Sequence:
MKDSMSILTQTPSEPNAAHPQLHHHLSTLQQQHHQHHLHYGLQPPAVAHSIHSTTTMSSGGSTTTASGIGKPNRSRFMINDILAGSAAAAFYKQQQHHQQLHHHNNNNNSGSSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALMHPHGKLGHFPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAAPPVDGGVDGGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPYAAAAGAAHGATPHTNIDIYYRQAAAAAAMQKPLPYNLYAGVPSVGVGVGVGVGPAPFSHLSASSSLSSLSSYYQSAAAAASAANPGGPHPVAPPPSVGGGSPPSGLVKPIPAHSASASPPPRPPSTPSPTLNPGSPPGRSVDSCSQSDDEDQIQV
The following text describes a protein:
Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
Subcellular Localization:
Nucleus.
Sequence:
MPLLTQQIQDENDYSLVASLDNVRNLSTVLKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFTVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVVNKVILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMESFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES
The following text describes a protein:
Function:
Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).
Sequence:
MSKVSTIAFKTPNKVWSVRRDVIFDESSILDPRKFSLELLGNENYEQVELPVSGGAYQAAFIHGALEETIYRYHPKGFLAEVNVDHVCQLKKSFYGLKQFPRQWFNRLDAFMTTHGFSRSAFGIYVYHKKMSGNSMIYLLMYVDDMLIVANIITEINALKKLLSKEFDMMDLGAVKKILGMEISRGDGVVHLSRKRYIEKVLERFNLHMSKPVSTSLTLYSTHSKLQMPQSADEVQHTSKVPYSSAVGSIIYAMVCTRPNCRLSLVYNRDEIYGSNRGSERSYLVDRFGGRSYLVERPNKAYLSKNLISLLAYGGVQKEFFMEILESALEETKQVYLKKRGALKENEMYLPMATVRMFTIWGSGLLIPFSIVHRKCRDNGQVSGRVLVYRNPGLHFGDVHAMKARYVEELVDIVGDAKYGIFCFTKGPRSAATEIANGDFDGDISSRFSELLSGRKGAYLLLNPTLSGIQKWVSFYGLGDHEISNPGHGGGAHVESHIGVACGRCNLVSFYCLRQSSSHELIFGVELRPRISDYLSWRNMVLQYLVFTFQLVDSYTSSKPWTRMHSTPKAVSKKPSEFSVDELEYELFRQFLEAKAEGYAYKFTYIILSNALTGKGMGFDVQRADIFSRYILWDWRNYLADSWLAFMDRLLMLRGDEVDGMHSLKGKMLHLIDIYYDALDAPKSGKKVSIPRDLKANKFPHYMEKGNPFSYHSTSILDQIYDHVDSYPDEDLCVTEIYKLPCFEVESPPTCMELWRGRYEEYKKDMTRAMNSGSEHRITSCNEVIKKYKKLLYGAVEFEQTVRKSEDIFNEALAIYHVTYDHARTTYNIEKCGFAWKVAGSALCRIHDADIEAKE
The following text describes a protein:
Function:
Probable co-chaperone that participates in the proper folding of biopterin-dependent aromatic amino acid hydroxylases, which include phenylalanine-4-hydroxylase (PAH), tyrosine 3-monooxygenase (TH) and peripheral and neuronal tryptophan hydroxylases (TPH1 and TPH2).
Subcellular Localization:
Cytoplasm.
Sequence:
MDAILNYKSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKDILTNEASRARYDHWRRSQMSMSFQQWEALSDSVKMSMHWAVRGKKDLMLEESDQTPTDKIENEEQDEQKEIKKEEFGSTTEKMEQKESKSVEKSFSPQNPDSPGFANVNCWHLRFRWSGDAPSELLRKFRNYEI
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPPQIKQDLNRSGWETTDFPSVCENCLPENPYVQMLKEDYGAECKICTRPFTIFRWKADRTARTKRTNICLTCARLKNCCQCCMLDLSFGLPIVVRDAALKMVAPGPQSSINREYYAQGHEKEIEEGRGAVEEYEKTDEKARELLRRLANSEPYYRKPRQLEAPEEDGETQGPSDATVVRSRYGNGPGPVRTSESRRGTPLPGRGRGGVRGGRPFPGTAQLPPSQADILPPADPNITSLFVTGVEDDLPEHALRSFFVQFGQLRSLVCSHRAHCAFINYAARESAEAAAKHCQGKAVVQGCPLRVRWGKPKALDNMDREERLKYAREGRQAVGSLGNADQGTKAITAGTEKEQIPRQVAVAPPPGSGEVQYSSMSGD
The following text describes a protein:
Function:
Functions in an output pathway of the circadian clock. One of three clock output pathways. Involved in negative feedback regulation of KaiC; deletion leads to overexpression of KaiC protein and decreases the amplitude of the circadian response. Overexpression reduces the expression of circadian genes.
Sequence:
MAFRPSRLAIFIDGNNMFYAQQKNGWFFDPRRVLNYFANRPEIELVNAYWYTGLKDPQDQRGFRDALVSLGYTVRTKMLKEFHDESNGNRYFQRANLDIEIVIDMFNTVEQYDEIVLFSGDGDFERAIELLRAKQTHITVVSTDGMIARELRNATDRYIDLNDIRSFIEKTERPEPFVSAPVIAPA
The following text describes a protein:
Function:
Has antibacterial activity.
Subcellular Localization:
Secreted.
Sequence:
MKISCFLLLVLSLYLFQVNQATDQDTAKCVQKKNVCYYFECPWLSISVSTCYKGKAKCCQKRY
The following text describes a protein:
Function:
Carboxylesterase that possesses esterase activity in vitro with the synthetic substrate p-nitrophenyl acetate (pNPA). Binds strigolactones, but is not able to hydrolyze them. May be involved in the regulation of shoot branching.
Miscellaneous:
MISCELLANEOUS: Gain-of-function mutant (T-DNA tagging) exhibits increased branching and decreased sensitivity to ethylene.
Sequence:
MSEPSPIADPYAYLNIVNNPDGSITRDLSNFPCTAATPDPSPLNPAVSKDLPVNQLKSTWLRLYLPSSAVNEGNVSSQKLPIVVYYHGGGFILCSVDMQLFHDFCSEVARDLNAIVVSPSYRLAPEHRLPAAYDDGVEALDWIKTSDDEWIKSHADFSNVFLMGTSAGGNLAYNVGLRSVDSVSDLSPLQIRGLILHHPFFGGEERSESEIRLMNDQVCPPIVTDVMWDLSLPVGVDRDHEYSNPTVGDGSEKLEKIGRLRWKVMMIGGEDDPMIDLQKDVAKLMKKKGVEVVEHYTGGHVHGAEIRDPSKRKTLFLSIKNFIFSVL
The following text describes a protein:
Function:
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.
Subcellular Localization:
Chromosome. Nucleus.
Sequence:
MSSPASASDVDSVKVKMDEDEIDVRDDDRHENGEDNDNDNEEMDDSSEEEDDDDEEEIARVRQGFIVDDDEEEEEVDKPRRKLKKRRRVIPEDTDDKPPTPAENDHLDEDDLDLLMENTGAPRERHFKRLKRAGDDDSSDRQKGLADMFSDEEEQPAPVEQRNEFDDFIEDDEFSEDDAPTRGRESQRESRATGAPAAFLSKDVGIDDDKLNEIYEVFGDGEEYAWALDAEEDRERAQEEYEDEGRAGPELRDVFEPSELRERLLTDEDNDIRARDEPERYQLLRQSIDKYDLSDEDFSKECEWVASRLKTMKQEHVPPHLDSEYETAVSKVLEFIAKENLEVPFIWHHRRDFLTHVSKHEKFKAKVEDDEYEPTLEAPVASTTEETKEIEYTTVELLSLDDLWMIVQLDLDYHGIVEKQQQLERLRTQAGVSKTGNHSFINDFANSASLQDTQDAIEYVQFRFSGELGDLQSGSSKRHSRYARYDRIRASKLYGLVRQFGISSDEFAENLETSTRINYTEDNARAPADLATDYLNDSSLVLSDAASALESATQMFAMELAFDPRVRRYVRQQFAQLAKIDVYATEAGSSQIDEAHPAYEFKYSRNLSFEELRKSPKLYLQMLQAEAKGLVNVRVSYPDFKTKFIDLLLSKLQSDGVSDIASQWNTQRRAVVRIAMKTLVPMVTRSIKEELRNDCERQLFFELRRMFGRKLNQAPFKPRNYEKGTVPRVLALSAGQADFRRDAVVGVFVDEEGRVAERAKLGAPQTQEFTNALSEMVKRRTPDLIAFSGQTVQSHRLKSVIEEVVRTQGLEAEGEPLEVRWVQDEVACLFRNSAGALVEFADSPPLERYCVALARYVQSPLLEYLSLGKEIKAIPMVDFQSLISEDRFYEAVDSTFVDYVNLVGVDINEAIRDAYVARMLPYIAGLGPRKASGLTHKIQSRGYLGTRLDLITEKLCGKNVFMNVASFLRLPYDKRSVRHEETELLDATRIHIEDYELAKKMAADALELDEEDLLEFESEGGVIAQLMKEGAEKLNELILEGYAEELEQKLGKKKRYTLEMIRRELINHYEELREPLHVLTDLEVFTMLTGETEKSLHPGSVVAVQIRRISDRYLAVRLSCGIQGNVTQDRITDQRGVHPSALFHHQQTIRAVVMEVSYSNFSAELSCLHRDISDAQKRARQVKRPRDQWDFEAEAADKSAQEVRREVEQRKTRVIKHPLFKLFSGSDAEKFLSTLPRGELVIRPSSRGTDHIAVTWKVGDGIYQHIDVVELGKENEYALGKTLMVGTSKYSDLDELIAMHVKSMARKVDELCHSDKYSADSIAETEQSMDSYLRGGSKRAVYRFVLSSKKAGYFHLLVKTDQKSPMLDWPVKVIPGGYQLGGEKYPDVMKLCNGFKTLFKSKTQRR
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MAATAVTTPVGTGGAAAARSRFAAACGALSQYVKAAESERMHARPPAPLRPLPLMPGADVDASPADLDLPQAAPAPAPAQLTIVYGGRVLVLADVPADKAAGLLRLAAGAAAERAETEAIGAKRRDHVSGSASAGADLPVARKASLQRFMEKRKARVAAVRTEPYRRPDVSDSCPDNLKLAL
The following text describes a protein:
Function:
Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MRLIITFLMAWCLSWGAYAATAPDSKQITQELEQAKAAKPAQPEVVEALQSALNALEERKGSLERIKQYQQVIDNYPKLSATLRAQLNNMRDEPRSVSPGMSTDALNQEILQVSSQLLDKSRQAQQEQERAREIADSLNQLPQQQTDARRQLNEIERRLGTLTGNTPLNQAQNFALQSDSARLKALVDELELAQLSANNRQELARLRSELAEKESQQLDAYLQALRNQLNSQRQLEAERALESTELLAENSADLPKDIVAQFKINRELSAALNQQAQRMDLVASQQRQAASQTLQVRQALNTLREQSQWLGSSNLLGEALRAQVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQPLLRQIHQADGQPLTAEQNRILEAQLRTQRELLNSLLQGGDTLLLELTKLKVSNGQLEDALKEVNEATHRYLFWTSDVRPMTIAWPLEIAQDLRRLISLDTFSQLGKASVMMLTSKETILPLFGALILVGCSIYSRRYFTRFLERSAAKVGKVTQDHFWLTLRTLFWSILVASPLPVLWMTLGYGLREAWPYPLAVAIGDGVTATVPLLWVVMICATFARPNGLFIAHFGWPRERVSRGMRYYLMSIGLIVPLIMALMMFDNLDDREFSGSLGRLCFILICGALAVVTLSLKKAGIPLYLNKEGSGDNITNHMLWNMMIGAPLVAILASAVGYLATAQALLARLETSVAIWFLLLVVYHVIRRWMLIQRRRLAFDRAKHRRAEMLAQRARGEEEAHHHSSPEGAIEVDESEVDLDAISAQSLRLVRSILMLIALLSVIVLWSEIHSAFGFLENISLWDVTSTVQGVESLEPITLGAVLIAILVFIITTQLVRNLPALLELAILQHLDLTPGTGYAITTITKYLLMLIGGLVGFSMIGIEWSKLQWLVAALGVGLGFGLQEIFANFISGLIILFEKPIRIGDTVTIRDLTGSVTKINTRATTISDWDRKEIIVPNKAFITEQFINWSLSDSVTRVVLTIPAPADANSEEVTEILLTAARRCSLVIDNPAPEVFLVDLQQGIQIFELRIYAAEMGHRMPLRHEIHQLILAGFHAHGIDMPFPPFQMRLESLNGKQTGRTLTSAGKGRQAGSL
The following text describes a protein:
Function:
May act as a specific coactivator for the mammalian TEFs.
Subcellular Localization:
Nucleus.
Sequence:
MEDVTKTTVHTQSPIKTEWNSRCVLFTYFQGDISSVVDEHFSRALGNVKSPQGQNPSSPSGDVLLRNDSDMPPNQWRFSAPWTKPQPEVSFANGAASCSLNGSGLMPMDQYPLSLTGGPSVQPGELWHFSSLASPSFPEPGYPHAFSTGHLVPEPQPEGKYEPLLSLLQPERCLTHPQESASWEDGNSAGSTGLLFNLPPSSAHCKEMPPIKKIYFPPDGGPAGASFAVERSQSPERRRDLFFY
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MSKSRVCPDKTINAEKETCAKKTNLLIYEREKGEACKPPKTYIPPISSPQVKRIKICTGAELKKMCAPPPCPCPPKIPRPTLLQRLGKLLGLGAKSLVALGAVYVTYDMGIWGDSKTTGELYKNVCNAILPNIIEPAKEKPLTSSCKAELELFNAFEKDPYCCDKFPIDSESSAYEVQQKWNKIVTKTFSAIAGFPATVRNWSHQVYCKMVDAESCKVAQDDGEEECCPCD
The following text describes a protein:
Function:
Acts in the nervous system to mediate the control of copulatory organs during courtship.
Subcellular Localization:
Cytoplasm. Note=Found in the cytoplasm of many neuronal and glial cells in the brain and ventral ganglion, and in imaginal disks.
Sequence:
MSTQTRSGGGGGGGHARNQKKSNASNSGGGGTGHHDGVSHAAAAGKKGGQDASKTDKPEKAQPKATTEQLRIAQITNSTTEDPQINEKVLLLLTMTQRSEEEVCCALNECDYDLEAAANFLIEELPQGAFAKYEKKRKNKAANNTADGAAGDGDWADGNGNADRREKSRNRSSNRGGTRGSSDSRGWRGRETRENERNQRESREPWSGQNAGQDRGDDRANDNYRGQRNGGGRSGPGGGGRGGGFVSRSGRGGGRMGGRTGGPRGDRGSGGPGGAYGSGRGGNANEDHHEVELWDNTIAQNAEKQQQAHDDAWGDWNNEEYEGSLKDSKVFTTSNLATQSAANVVSGTGASVTAVPAAAGTEISAPPGLEHQLVQQGSHLEESSSSGPAAVTPPATLSGSATTPLLQYSAAVSNPPPQLQSQGTQSGAGTGASAAAGGGAGSTPSSFVSASPDTFSSAASAAATLVHQAQKQQQLQQQTTPIKPSATLSVEQSQYFNSLASQGVSPGSVPVQSAPAGYAQNPVAAYSQTSTSVGVSQYPNTYANVFASGTAAGAGTAEQSQQQPQIRRARVKLPPPSKIPASAVEMPGDNALNNIGYLDVQFGALDFGTDDGFEPLPEKVGSGFSIDGQQQQQQPDDYQSKSQQQQQVTLAAGLQSSQISDALNAAGYTSRSTSQQQQGVSSAVNATIDQLTKSDPYGQTGGSGNAYQNAYQSSGASKTASGFPTTAPGGYSSSTYANVQSSVANSYQQQGYGSYQPSSYQQQAGSGAQSGTGAVSGGGGTATQNIPVGGSSSQNSTSGNASSAYLTSGYSTPQSAYQSSQSVYGNTGLSNSSGFSGSASNASSQYANFSASAKLKDATTASSAAHYDSVSTSSGVSSNSGSTGNGGVVSGQTGANQAAVSNNNSVSGSSSVSNVTAGVASGNVAGVGGGVSQSGVSSGVGVPGGSASSVGVNVNNNSSSASSVGAATVAQTATGTTAAVLASLTNKNTSSSNSSGSGGSAATTTGNASGQGAGASTGGVGSSSGAGGAGSGGGSGSGLVPTNIQMVSQYIQTGLPYYQQPVYSYEELQMMQQRVPHVQGYYDLNYPPASLGAGRDNLGSVTYSAMNDGRFARTDNNSSPVGNVSSTMSQQAGSSAPMLNVPYAYFYGGNVMPGSFQYGTPAIYPQIPAANTASGQQFPKPSYSAGYGSTSYDTLSQTTQDYSKGGYSSSVNQQSKTQTVSNQSQAGTGSDLTSSMYGKGHVALNKVNSYEKQSFHSGTPPPFNMPNTQTAGGTSAQPYGMYLPMPAAGHHNMIHQPIHQVHSELPLQVVVGGGTESHVLIHGNVNGPQVTYHRIWQTEPVQCQNQLVAAHCNNFEPNIDCCVHDNNNDLSFFAD