lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Sequence:
MDNDFLEEQQVPSGLLIGIKFDVSTEEDMEKISVMKIDAVNEITDPKLGVPNPSCQCSTCGAKDTKKCEGHFGVIKFPFTILHPYFLTEVVQILNKICPGCKSTRQGQWVKVRRLRSKGCKYCAANSNDWYPTMKFKVSSKDLFRKTAIIVEMNEKLPKKLQKKSFRPVLPLDYWDFIPKDPQQEENCLNPNRRVLSHAQVHYLLKDIDPGFIKEFVSRMDSFFLNCLPVTPNNHRVTEITHALSNGQTLIFDQHSRAYKKLVDFRGTANELSCHSASKMSGLKWIKEVLLGKRTNHSFRMIVVGDPKLRLSEIGIPCHIAEELLISEHLNSWNWEKVTNGCNLRLLEKGQTYVRRKGTLAPVRRMNDFQAGDIIYRPLTDGDIVLINRPPSIHQHSVIALSVKVLPLNSVVSINPLCCSPFRGDFDGDCLHGYIPQSVDSRVELSELVALNRQLINRQSGRNLLSLSQDSLSAAHLVMEDGVLLNLFQMQQLEMFCPYQLQSPAIIKAPLLDTQVWTGKQLFSMLLPPGFNYVFPLNGVRISDGELISSSDGSAWLRDIDGNLFSSLVKDCQGKALDFLYAAQEVLCEWLSMRGLSVSLSDIYLSSDSISRKNMIDEVFCGLLVAEQTCHFKQLLVDSSQNFLIGSGENNQNGVVPDVQSLWYERQGSAALCQSSVCAFKQKFRDIQNLVYQYANKDNSLLAMLKAGSKGNLLKLVQQGLCLGLQHSLVPLSFKIPHQLSCAAWNKQKVPGLIQNDTSEYAESYIPYAVVENSFLMGLNPLECFVHSVTSRDSSFSDNADLPGTLTRRLMFFMRDLYIAYDGTVRNAYGNQLVQFSYNIEHTSTPSDGINEDTCAYDMGGQPVGSISACAISEAAYSALDQPISLLEPSPLLNLKRVLECGLRKSTADRTVSLFLSKKLEKRKHGFEYGALEVKNHLEKLLFSDIVSTVMIVFSPQNGSKTHFSPWVCHFHVCEEIAKKRSLKPHSIIDALYMKCNSARAESKINLPDLQITSKDCFVDMEKEDSDCFCITVSIVNSKKSCIQLDTVRDLVIPFLLGAVVKGCCIKNSDVLKSSSGRLYLRVYVSGDCGKKNFWGVLMDACLQIMDMIDWERSHPDNIHDIFVVYGIDAGWKYFLNSLKSAISDIGKTVLPEHLLLVASCLSATGEFVGLNAKGMARQKELTSISSPFMQGCFSSPGSCFIKAGKRAVADNLHGSLDALAWGKIPSVGSGGHFDILYSAKGHELARPEDIYKLLGSQTSCHEQNLKVKVPITCYQTTTKCGAQLVYANGDSASKGCKSLEKISKSVLRSFLSLNDIQKLSRRLKFILQKYPINHQLSEIDKTTLMMALYFHPRRDEKIGPGAQNIKVRYHSKYHNTRCFSLVRTDGTEEDFSYHKCVHGALEIIDPRRARSYQSRWLPYSEVLNLYRTLINR
The following text describes a protein:
Function:
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPRVGLIGGSGLYNMTGLEVIKKVKISTPFGDPSGEFIIGRLEGVECVFLPRHGYGHVHNPTEVNYRANIYGMKVLGVEFLIGVSAVGSLKDDIVPGEVVLVDQFIDRTHHRQHTFFENGCVGHVSMAHPVCEKLREYLYESCEEACSSAKVKFHAHGTYVNMEGPAFSTIAESCLYCSWDADVIGMTCLAEARLAREAEISYAVLAMATDYDSWHPNHDNVSVDAVVAVLKV
The following text describes a protein:
Function:
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Subcellular Localization:
Nucleus.
Sequence:
MSAKVQKLEKQFLRNAEIEVSGTETGELAIFQGISVFVNGYTDPSAEEIKRIMMVHGGTYQHYYKRKPKCYMISTNLPMAKLKSLRDYVVRPSWITDCVKAGMLLPVQDYLLYSPDLKKGQQMINRVQLADDSGTSAMTSAEAHNDEQDGWLSSDNSVDCNLECEQLHGDQNGTDHGSPPQEHKSNDSPRYQAGDPRFLQEFYGRSRLHHISTASLKLRDYVAQLRSAGNFNFVGVQRLKSHLEEQTLAERVQVPGKVLMHIDMDCFFVSVGLRSRPHLKGKPVAVCHGKNGGIQPSSSHSRASDVPGTSGSGADGKGLMSMSEVASCSYEARDAGVRSGMFLGRAKQLCPNLVAIPYEFESYSEVSKILYDTVASYTLDIEAVSCDELYADVTKVLQEAECTPNDFASFLRKEIEEKTCCTASVGLGPNMLAARVANRSAKPNGHRFVSTSELLEFFKAVAVKHLPGVGYRLQSQLTDMGIETCEQLQAVSMETLKSKFGVKTGTLLFQHARGSDDKVLQFNKVRKSVSAEVNYGIRFKEANDMNKFIGQLSEEVEKRLREAGVQGRAVSLKLKVRQKDAPLNPTKFMGHGMCDNITKSVQLLAATSSAAAISRECCNLAAQLHLVPSDIRGVGIQVGRLEPRPGVQSCASKTMLDFLTDNRSTLGAAHPSAREGATPGEGGSTATAANGLGSPPQAVSLPAFSEIDPAVLESLPEDIRQEVLTMYRESRRNPPRTNAREDVSGITGTAVASTSGTKPKPPLGKRKGRPPKTASPQKARGPACHSLREYMVKPAAALATAAEPSLSVISSKDKMEKVKMLLQEWICSRDGEISNTDVDAWTQLLGGVVQERNLEKLDLLLKFFYRTVQRSGSKKWEDTYMKVINVVQTEVLQAFGHFMKLQIF
The following text describes a protein:
Function:
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Sequence:
MPPLSVRDVASLLLIPLLFYLFLWFWLDSDPDLQPGLFDFEDDEFLGRETNPESNPDVVDLDGVADGEFGVSNVVERVLCPKESFKLATMENCLPWLGCKEITDEVIVHHMLGQGAVKQVYKATWRGHTVVYSNLTQQAFLQDFLHGVQMLRKMQQTSHVVQLVGSCHTTLLTEYHRLGSAENIETILDSEEFSNFSNVRARFDMAMSYLEAIHFLHNSPVGTRVMCDSNDLLKTLSQFLISEDLKLVLNDLDALPEVNPEAQLFVKCGSREIKSDFVAPEQLWPFENETFDDSRMPSYDEKTDIWKIPTVVDYLLGNVNGSDVVRLHLFKVHQQCKNRDPKQRPSAKVLLEEYKRARSMLFSV
The following text describes a protein:
Function:
Component of the non-specific lethal (NLS) complex, a multiprotein complex that promotes expression of housekeeping genes on X chromosome and autosomes.
Subcellular Localization:
Nucleus. Chromosome. Note=Associates with promoters of housekeeping genes on X chromosome and autosomes genes.
Sequence:
MGRRCCVANCPSTSRLLEHNGVTYHSFPLDPIIRAIWIKNSRISLERQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAASSEATVPAPGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLPVAAYHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTALTPVKRAKLEAPDLPNVPQPEAAIDPEECQYRLIEHIKVQQSLVLDRLNDIEAEMDELEKEDTLDDLKDADISTTKEALATFIKELETMKRLAKLNQVANMKQTLRDSATSK
The following text describes a protein:
Function:
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.
Sequence:
MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
The following text describes a protein:
Function:
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit polr2a, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs).
Subcellular Localization:
Nucleus. Chromosome. Cytoplasm. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
Sequence:
MSKYKNSSLLNDQGGVRQPSLSNGSSVLGISNQLPPNSLFHLFSTNNQQSTTTPTTVTIQPPSSSISTPSPTTNNTVSGGGGIQTAGSSTSSASSVVGGGGGTTTPTNSNIVVIESNKEDDKECGTILMEINKGIRSGNLGEQIESILFFSHLIKFHPSPLIVNSVITRLSDIFRTTSNTVKYRILKVFQECSSEIHKVSNIEEVLKRIHSVILSNDPIARSLSLRVLGSVPHLIADKLYIHHSIRTCMQSHDQVELEATIFIMDKLCEISPLFSDSIIEKIHTVIQNVETPPITKLKYTRLFRHMHHSHSIATQSKEMLVGLLDLYPSVGFVSVILDTLTNLSLKHILYIDDHIKFLKNYGFSDSRVVVKVIALKCLQKLAITSPHSQFPIIEIFNIIKETPSKSYREIKYNALLLLSILSQSQYTKILELNQANDNDLIDILYQYSLDYDFKLSELSIQTLVNIIVESTDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKLIESILNQTVNNICVILKTQFTTSTNNNTNINENKSTLNKTSVFLKSIIRLIKKDPKPLKSITTTIISLLNEIPYSILKSLFHCLSMCIPMNKSVLNQNGWFKLILDYLNNLIIKENSVQLINNNFNNNNNNNNNSNNNNNNIINRNNNGISNGINKQDCKYSIPMSIFMCIFKTFDENNQKIQEITEQLLPLIQYILENPKPDQLWSCYNLAQLSQRHGFHKIAMVIYSTLIHKVESECNYLWLKGLLSIATLENEISIYSITTNKNNTNNNNNNNNSKILNQLSNYHTSIVSLKASSQQERSLQFQEDFILLHEKYLFNILNLKSFLLECNDDGNNNNNNNNNNNNNNNNNNNNNNNNNNEILLKRFLSKSLIFRQLEQKYQLLLNIQSKSINHTVPLDTKQILESFIFSCNLIVKLIDLIVINKNNNNNNNINANGINHQQEQRYQQHQQSQNQELINYFPLFKFCEFIQKKLNQQHSIPSSSSSSSSTTNPISFLDQVLNGLIKIPMVYPSSFYFKF
The following text describes a protein:
Function:
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
Miscellaneous:
MISCELLANEOUS: 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.
Subcellular Localization:
Cell projection, cilium, flagellum. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.
Domain:
The RIIa domain mediates interaction with AKAP3.
Sequence:
PQTDKQVCIPPELPELLKTQPPDLIQWAAEYFGAMSRGEIPPVRLIIHADELAQMWKTLKIVCEVLSCDHDGGPPRIPFSTFQFLYTYIAEVDGEISSSHVSRMLNYIEQEVIGPDGLIKVNDFTQNPR
The following text describes a protein:
Function:
Could function as a HCO(3)(-) -sensing component in the CO(2) signaling pathway in guard cells. Acts as an upstream repressor of HT1. Plays a role in stomatal response to CO(2).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSETSKSESLDPEVSEGLCSKTLMQSIVHELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTGFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMAVLLLLLISVPISFLWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLHIPINIVLSKARGIEGVAMAVWITDFIVVILLTGYVIVVERMKENKWKQGGWLNQSAQDWLTLIKLSGPCCLTVCLEWWCYEILVLLTGRLPNPVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALVMIAFRGFWGSLYTHHDQLILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATLAFKAKQGLQGFLIGLFVGISLCLSILLIFIARIDWEKEAGKAQILTCNTEDEQTSQGSGQDSHS
The following text describes a protein:
Function:
3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MQFSGEGLFFHSPFNSPKKHMFSSSKGLFRGHPCPSIAAGQFCRLLCCPFDHPERVKRESENGSDSAEMVKRRKLEVGQGVARVAGDSSGGKLELPGARQALNQRDRPEIEGVGASPKTEGGRAEGAEKKEFASSQSSQKEQQETPHASATPQASVSPQTSAPPQHVSSSVSEDVLKQGKNGITSKSEKSSVKQPGSRDIYQPSSSREPPVSSIDTRTSSSPKSALEAVMTTSASPSQSRDGSRNTSASPSSSRDAEHLMPTTIFPCPATVPQRIAYLKAIHSALTDKRKLKFPKRAAILEELAAAKRSAGNYMVYTNECRVLVKSIKDGSWRGGKAGGTKTDSKTSGHITSSISNQLDMLASKTKPLLAQNGYPVNPDPLKSGLPSNIGIQHCDRCDKAFDVPKVDNYGSCKYHWARARMGGNSTMPEKFYPCCNQPVGMSEGCEEAPRHVYKLHDLNDLAFVIPFRTVSTSESLDTSTSTSTSTSATTSAPSAKSTKTASRPASTPTKSLTSSLDLEKSRQPFNKARRPRTIFNGPAVNQREPDITLETMKRGIGESRGQADSQERSSEPRERSARVREQPSGSCDQAGSLQTSVVAVDCEMLYTSLGMELCRVTCIDYHGKKTLDRVVRPTGRILDYNTRFSGISDINEPIITESGEKGDSISFEEAHRLILKLINKQTILVGHGLENDLIAMRLIHDRIIDTSILYPDFNPRYKTALKTLALKYLKRTIQTGEHDSMEDALAALDVVKCHLKG
The following text describes a protein:
Function:
Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated-killer (LAK) activity, induce dendritic cell maturation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity (By similarity). The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (By similarity). In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy.
Subcellular Localization:
Cytoplasm. Secreted. Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins.
Domain:
Both the Ubiquitin-like 1 and Ubiquitin-like 2 domains are required for its efficient conjugation to cellular proteins. The two domains play different roles in the ISGylation pathway: Ubiquitin-like 2 domain is necessary for the first two steps allowing the linking of ISG15 to the E1 and E2 enzymes while Ubiquitin-like 1 domain is essential for the final, E3-mediated transfer of ISG15, from the E2 to the Lys of the target protein.
Sequence:
MGGDLTVKMLGGQEILVPLRDSMTVSELKQFIAQKINVPAFQQRLAHLDSREVLQEGVPLVLQGLRAGSTVLLVVQNCISILVRNDKGRSSPYEVQLKQTVAELKQQVCQKERVQADQFWLSFEGRPMDDEHPLEEYGLMKGCTVFMNLRLRGG
The following text describes a protein:
Function:
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Sequence:
MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA
The following text describes a protein:
Function:
May be a zinc metalloprotease that specifically cleaves ubiquitin chains.
Domain:
The JAMM motif is essential for the protease activity.
Sequence:
MAAELPFYIASSVEELVKKHVEGVEVDKNYSIFHYLSTCNNLVKQADIYKSEGDIERTYIYSLRFCILIFEKLQKHPDFNKESFTKSRNEIKRKAELKLKELEGLKETLKKGYERIQHKKEEERKRIEREKEKERIFKQEKLKLEREQQLLREEEEQRKREDLELESEIQRLKEVEDFENRKLQAQKNIKRATSARTFELLRQEALLEERKRLQGIETEKKRILAEKQEALEKEFQQQLFEQQEKERLEKERLEKEEQLRLASLPPPPPDYSSFDSDQLLNLIENNNKKLENNNQTDDKLDNEFLLDPSFLPPPPPIITQPSPSQEKKDNNNNNNNKNTTAQLPLSITQPPHMPNNEKKLPPIYNSTSPIQFGYPSLNNSVNNPPSFSLQNNTPLIQQYKQQQQQQPIQSPTNNINRPNIPQYNNYNAKPLSSNLNPLPPQYQPQQQQQYQQQQQQQQYQQQQQYQQQQQQQQQQQQQQQHQLPKLPQYQPIENKSISANGLAQSPAVNTPSITPTTNKPNIDSSEASKKYSKLRKIIVHGEVFQEFMRLAENNTKRSIETCGILSGTLSNDVFRITTIIIPKQEGTTDTCNTIEEHEIFEYQLENDLLTLGWIHTHPTQDCFLSAVDVHTHCSYQYLLQEAIAVVISPMANPNFGIFRLTDPPGLETVQKCKLKSFHPHPPVNGIPIYTKVDHVDLIWGKKSDSKVVDLRFLKK
The following text describes a protein:
Function:
Histone methyltransferase. Dimethylates 'Lys-4' of histone H3 (H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Methylates only a limited fraction of nucleosomes of target genes (e.g. NAP and XTH33). Involved in epigenetic regulation of the floral repressor FLC and FT to prevent the transition from vegetative to reproductive development.
Subcellular Localization:
Nucleus.
Sequence:
MISMSCVPKEEEGEDTQIKTELHDHAADNPVRYASLESVYSVSSSSSSLCCKTAAGSHKKVNALKLPMSDSFELQPHRRPEIVHVYCRRKRRRRRRRESFLELAILQNEGVERDDRIVKIESAELDDEKEEENKKKKQKKRRIGNGELMKLGVDSTTLSVSATPPLRGCRIKAVCSGNKQDGSSRSKRNTVKNQEKVVTASATAKKWVRLSYDGVDPKHFIGLQCKVFWPLDAVWYPGSIVGYNVETKHHIVKYGDGDGEELALRREKIKFLISRDDMELLNMKFGTNDVVVDGQDYDELVILAASFEECQDFEPRDIIWAKLTGHAMWPAIIVDESVIVKRKGLNNKISGGRSVLVQFFGTHDFARIQVKQAVSFLKGLLSRSPLKCKQPRFEEAMEEAKMYLKEYKLPGRMDQLQKVADTDCSERINSGEEDSSNSGDDYTKDGEVWLRPTELGDCLHRIGDLQIINLGRIVTDSEFFKDSKHTWPEGYTATRKFISLKDPNASAMYKMEVLRDAESKTRPVFRVTTNSGEQFKGDTPSACWNKIYNRIKKIQIASDNPDVLGEGLHESGTDMFGFSNPEVDKLIQGLLQSRPPSKVSQRKYSSGKYQDHPTGYRPVRVEWKDLDKCNVCHMDEEYENNLFLQCDKCRMMVHTRCYGQLEPHNGILWLCNLCRPVALDIPPRCCLCPVVGGAMKPTTDGRWAHLACAIWIPETCLLDVKKMEPIDGVKKVSKDRWKLLCSICGVSYGACIQCSNNTCRVAYHPLCARAAGLCVELADEDRLFLLSMDDDEADQCIRLLSFCKRHRQTSNYHLETEYMIKPAHNIAEYLPPPNPSGCARTEPYNYLGRRGRKEPEALAGASSKRLFVENQPYIVGGYSRHEFSTYERIYGSKMSQITTPSNILSMAEKYTFMKETYRKRLAFGKSGIHGFGIFAKLPHRAGDMVIEYTGELVRPPIADKREHLIYNSMVGAGTYMFRIDNERVIDATRTGSIAHLINHSCEPNCYSRVISVNGDEHIIIFAKRDVAKWEELTYDYRFFSIDERLACYCGFPRCRGVVNDTEAEERQANIHASRCELKEWTES
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Miscellaneous:
MISCELLANEOUS: Present with 18000 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Sequence:
MVVLAASITTRQGKPLLSRQFKDLSKDRVLELLSNFQNLVSEISSDHTFVEDKHVRYVYRPFDNYYIILITNRQSNIIKDLATLNLFSQTINSYLSSFQDQEIFHNAFEILSSFDEIVSMGGYKENLSFTQVQTYLSMESHEERIQEIIERNKEIEATEERKRRAKEIARKEHERKHGFMSSNGDYDGANRFMGSKDPNVTNAINSYYSHASPAAQQSYLQSSHAAAAEVAPVASPMATSQRAGHSATGGMKLGGGAGRRAGAAPRPSAISSASSGTPPPPEEDVPENNGILISIKEVINAEFSRDGTIHSSELKGVLELRINDHDLSHSNLKLADSIDVRDKSFQFKTHPNIDKQSFLSTKLISLRDKSKAFPANDQSLGVLRWRKVAPAEDDSLIPLTLTTWVSPSESQQGFDVIIEYESVLETELADVIFTIPVFPQEPVDINTESSTCSDAEVVNMDQEMGTSIKISKIAANDAGALAFTIEAPYEDALYPMTVSFQESTRDKLAKSFTGMAIQSVVMANDHDQELPYDVITSLKSDEYLVQ
The following text describes a protein:
Function:
Dehydrogenates carotenes in the trans conformation: converts all-trans-zeta-carotene into all-trans-lycopene, one of the last dehydrogenation steps of lycopene biosynthesis.
Sequence:
MASEGGSVRHVIVVGAGPGGLSAAINLAGQGFRVTVVEKDAVPGGRMKGLTLGASGEYAVDTGPSILQLPGVLEQIFRRAARRLEDYVKLLPLDVNTRVHFWDGTHLDTTRHLDRMEAELAKFGPRQASALRQWMEDGREKYGIAYQKFICTSADNLGYYAPWRLAPTLRFKPWQTLYRQLDGFFHDDRVTYALAYPSKYLGLHPTTCSSVFSVIPFLELAFGVWHVEGGFRELSRGMMRCARDLGATFRMGTPVEKVRVDAGRAVGVKLVGGEVLDADAVVVNADLAYAARSLIPAEAREGSRLTDAALERAKYSCSTFMAYYGLDTVYADLPHHLIYLSESARRTDRDALEDRHVDLEDPPFYVCNPGVTDPSGAPAGHSTLYVLVPTPNTGRPVDWVKTEQALRERIPAMLEKVGLKGVREHIREERYFTAETWRDDFNVFRGAVFNLSHTWLQLGPLRPKVKNRDIEGLYFVGGGTHPGSGLLTIMESANIAADYLTREAGKGPLPGWPYVPPLEPESPVQARAG
The following text describes a protein:
Function:
Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MPDANEVKPKKGWSNPALRMMGIPRISLPSRNWMIFWTVVTTIGGGIAYDKYEQKQMRKKWMDAVKQFGEVSYGANEIPRKLSIFIAPPPNDFLDESLKLFRKFIKPVLNAGVVDFEIFSESRQGDIRASVAEKIRELRRKQLVEETPKKNESNGNQDNDEEELKSRSDLYKAKDVLGLYKVFPADINVKSEDAIDDSSAGGIICVGRGAYKEYLSGVHEGLLGPLEKPQSVIDEETKLAEEKKKEKEENPDKDDDNDEEQSNLKPVPLRYIKPEDYANAQLAPELDLSTVVKDDKGVPVFFEQPVYTFPLPNLVGFTNIPRKIYRYFTKRFLVDDFGERTATIVNNKSRPFVYKDVLMAKEEEMDWPKKWVEKGKERNSEWVQELEHDERVTSRMKVFE
The following text describes a protein:
Function:
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Required for conjugation and efficient meiosis.
Miscellaneous:
MISCELLANEOUS: There are three genetic loci for mating type genes in S.pombe, mat1, mat2-P and mat3-M. Cell type is determined by the alternate allele present in mat1, either P (plus) in a h+ or M (minus) in a h- cell. Mat2-P and mat3-M serve as donor of information that is transposed to mat1 during a switch of mating type.
Subcellular Localization:
Nucleus.
Sequence:
MDPRLRAPIFLPILTPETLQKKKQIKGNKTTIYKNGFMLFRSRLHKILNLSGDWAGASAKCSIIWHTLPQNVRLAWSQLAELSHYQDVRRQIAKLERILYSKRLNGHNNYKLHISRVQ
The following text describes a protein:
Function:
Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.
Sequence:
MDYSAITQDPDHPSGTDPWASPRATQSSYTASNNNDIPPSPLPPHHQPSYNGDQEGDDSGPRSSENGAPDSPDLSARLQSAQLGDPDYAVEQPPYATQAQYTNEPRSQLLGRSQTGARQNAKNGPAYKIQAKITGLERTGKKDPILRFDVHTNVPKFRTTQYRDVRRTHAEFAKLADHLISANPEVLVPAVPPPLTPAGAGTEEDEIRVKASMQRWLNIVMSNEILMQDDEVVLFVESDFGYSPVVRMKQPATGVRRKVLKQFAPPPDDTPELQDARPIVKMFYLGTMDASHKVDRVVKARRGLGLAESDFGVKLGQMHVQETHPGLANAYKKLGKVIQTVGDYHAVQATAEATTLEDPLSYHSSDAFIVKETLTNRHILLRELIQAQQATRSKRAAADRLKVSSSVRPDKVDEAINALDEAQSHEDYLTKRTQRVTSNLLLEKRAWFERTSNDMLNSLREYTLRQIEAERRTLATLESVRPDIRSIDSSGGLSRLGREAHPAVRRANLASSQGPKGDAWSGIPRRSDSLGRSLSGSFVAPAVDEDDETNRSGTAKGRLRSPSGVGSIVVDDDEDRLDAKNAASRLATSTF
The following text describes a protein:
Function:
May be involved in recombinational repair of damaged DNA.
Sequence:
MGRKLMLRELKIENLAIIDELDIEFEKGFIVLTGETGAGKSIILSGINLLIGEKASVDMIRDGEENLVAQGVFDVDEEQKKKLEAMGIDIDGDEIIIRRSYSRSGKARAFINNVRITLTDLKEIASTLVDIVGQHSHQMLLNKNNHIKLLDSFLNKDEKDIKENLASLLYQYREIDSKIEDIEREKRETLEKKEFYEYQLEEIEKLKLKDGEDELLEVEYKRVFNAEKIREKVYESLEYLKNDDDSALSLITNSIRNIEYLGKYDERYTELAKRIENAYYELEDCANEIEDISKGIDVTENDLDKIASRMNTLKRIKEKYKRTLPELIEYREDLKEKLSDIDSGDFKTKELKKELNKIKDEYDKIAEKLTNSRKEIAVKIENELLNELKFLNMEDAKLKVQINKLERMTNEGYDDVEFFISTNVGQDLKPLNKIASGGEVSRVMLALKVIFSKVDNIPILIFDEIDTGIGGETVRKIALKLKEIGDNTQIISITHSAVIASKASQQFYIEKYVENSKTISRVKKLSAEERIKEIGRMLVGEKINNEVLEIANKMLNEV
The following text describes a protein:
Function:
Responsible for methylating the 5'-cap structure of mRNAs.
Subcellular Localization:
Nucleus.
Sequence:
MALRPEKPVWMSQEQYDRQYGKLEEPKPPREESKPGDQAKPSAEPKSGSEEKTEGSSSSTGQGEERPHFKIQKRRHQNYDLEERKKKQQLNKLREEQLKQHDIEMAANKVVNVDQIVREHYNERTFHAKRYNRNYSPIIKLRNFNNAIKYMLIDKYTRPRDVVLELGCGKGGDLRKYGACEISQFIGIDISNESIREAQRRYLNMRDLDYQVILITGDCFGESLGVAVQPFPECRFPCDVVSTQFCLHYAFETEEKARRAILNVSKSLKVGGFFFGTIPDAEFIRYKLNKFSKEVERPSWGNSIYKVVFANNSYQLNDYEFETPYGNMYTYWLEDAIDNVPEYVIPFETLRNLCDEYGMELEMQKPFNKFFVEEIPQWMNKFSPRLREGLQRSDGKYGVEGDEKEAASYFYTVFAFRKVKDYVENAPAHA