lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Sequence:
MAGLSCSEDQYYKKVTEIQQEIYEREKRRLQLERELFVYSRSDKRISQINSSKLRSYLKEITDREVGAKMRNLELQRAAESIEISMREYHPECGSLQQQKADFLKKISKYKKGKQKPAPRHEASKNEGVHIQHPKSHISHPGRHFPQSTVETFTDHQISRDSDSETADTSVRSHKAFLRSPNRSVHSHGRTPSGLLKDFRVGGKDGASKQTHLSDDISGSNGSLDGCNWSNKHERTVGLLPSVRALTGAAGSIASGSDDQQEASPFVTLKGSEKNPSPSNDTPMRPKHPPAESRDSQEAVHEPLIMGDEQRGLGHLMSETTLEKEAQERSGTHESLSASSSDVQLSESSASDLTLSLTQSELEDDVPDEAELERESLFEGRDHHKEHCLQTSLNSNGSNNTSQLDNESTGPAVTSKGLSLEGLFNLLDGIEGRLHGEQTCVYRHSTIDGRQLDEMISLCDDGAGLNDEDLEACGALVLRELQRLSWSTEKGCLLPQDVVSAHQSSTKPYEISASLPPNAARLWDRWFKHALVLKEHRVLSTERLVHLFTPLLLQRHATYSQQAKVLLRTLLSCSNEKRPSADDKSDLSSLCSPSAVADRNAEPVGSKQKRQIQELQRTEEDSPDESSVESGPIRESKAYQSLKQSAMQEGRLQQEDDEEEEEEEEEDFPGINQGHEEDLGRAKRSSHQDPYPGRGNSKAPQSKGFWLESDDSNSEIEAVLRPQN
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein.
Sequence:
MNFIVSLFFFIAFSFAYETKPVLLILQFQKQADSFSQLISMLKNEGKLVETVDMDTPIVFESYGEFNYEAVYILAPKYNFAYIKKQTLKSFIAQGGNVFMAYSPVYTKETKSFLELFKVKLSPSTDIIEKDIQTLSNSLFPTTTVYYRGISFTLPDSNAFVPLLKSTPNKILSFTFQSLTNGRLAILGSIDMLNNTYFEKNKQFIQPLLQWSMKTHGKLELKNIQIIKIDGVPDIENEGMFFTNDTVTVSFDIEQTMNGIVSGYIADDVQVEYRYVTPVILDFAQNLKNGSYSFTTVLPDQFGVYTIKINYTRPLLSSLHFEKVTPIRPWRHDHVARFQQQCYPFYLAFFGMLISTILFVFFYLNYKEPPKNTKTD
The following text describes a protein:
Function:
Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.
Subcellular Localization:
Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane.
Sequence:
MVQQTSIPVTEQHEVDENETVNEKLRLVPHDDEDQGCWGTRHTLVLLGFLGFANVYAMRVNLSVTIVAMVNQSAIPHINQTAVDICPETPGESQSGIVKDGEFAWDEYKQGIILGSFFWGYVLTQIPGGRLAELFGGRKLLGYGILSTSIFTLLTPFAARASDTLLIFCRVLMGLGEGVTFPAMYAMLAEWAPPWERSKMAAFVFTGAQFGTVITLPLSGILCEHGFDGGWPTVFYVFGTLGIVWFAVWMPLTADSPSRHLKISKEEKDYICSSLKDSIKRKSAPVPWRCMFRSKACWAVGAANVGHAWGFYTLLTELPSYMDNILHFNMKQVNTDPRWALIGAGFIGCDTVAAVILLTLAVGLSGASYSAFQVNFVEIAPPYAGTLFGITNAVANLCGFMAPYAVGVLVKGNQTLGQWRLVFLIAAGVYFVSNTIFLMFGSSKVQPWAECEDLGPF
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MKLILSTLIVFIHTLLVSALPTKEGSDPNSAKKYLVSDLPGLHENITPDNSIPLMFAGQLEIYPETDTHYFFWKFSDSNPETVTNRTIFWLNGGPGCSSMDGALLETGPFRINSQQQVISNNGSWHKMGDIIYVDQPAGTGFSYSDTYITDLDQVAEYFLKFMEKYYELFPEEIGYEIYFAGESYAGQYIPYIADAILQRNKKLVDGEHKYDLRGVLIGNGWVSPNEQSLSYLPFFKDHGLIDVHHPKWATLLAKHEQCQKIVNKIDSTFDDGVVHYYEVSSSTCEAILTDLLEYTQDTASEKDQRCVNMYDYTLRDSYPSCGMNWPYELVNVGPFLRQEKVMHQLNLINLKKWNECNGRVGRTFQARHSIPAVHLLPELAKEIPVMLFNGANDIICNSQGVLSYLQKLQWNGETGFTNKDNQISWIYDNKEVGYIIWERNISFINIYNSSHMVPYDLPDVSRALIDLITGKYDEKDVDGKKSFVTYPLGSRKESDASADGEENAGSDKVPGDSPSQTIDPMISSSTASSSSVESSLSSSTASADSDSTSSKFTRLIQLAVILVIFWGVYVLYASYKSRPSSIIKKPTNNTSNVTRSSAGKKKNVQWADQLNQFEDDERTQEPNQGIIAKAIGKITGSKDTRGRYAPVQRGNGNEYIDDIELGEGLSDPNVDEFIIGSDDDEEQGQAHSGAATHNQKQKPMN
The following text describes a protein:
Function:
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression.
Subcellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Midbody. Chromosome. Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase. Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase.
Domain:
Microtubule binding occurs via a basic patch in the central spectrin-like domain and also requires the unstructured C-terminal domain.
Sequence:
MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTGRHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQRELSKASKSDATSGILNSTNIQS
The following text describes a protein:
Function:
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MFLAIVGIVYILLVPEETEAINPPTAVLDLSDKFLDVKDEGMWFVEFYAPWCAHCKRLHPVWDQVGHSLSDSNLQIRVGKLDCTRFPAVANKLGIQGYPTITFFRNGHAIEYRGGREKEALVSFAKRCAAPIIETIKENQVEKVKLSARSQPSYIFFGHSSGPLFDAFNEAANAKFSVARFYTVAPSKEETNFRQRVVVLKDNVEIEFQEDIEALKDWVVRERWPTFVHATSSNLAELGASGKLVVLIVSSESQKFNTTSPVREFHKVAEDASKEMRKHSALWNRFQFAWLDGSDLASQIQMASVSEPHLFVFNYTSYEYYLSEDEPSQMTIKSIFTFLEQTAEGIDKGTIIAFGGRNLLTRMKRMIFELYWNIAQMFATQPLLSSCLFGVPIAFLSIICYSICSADFTVDRDEFYGDEALEDEEEETDTIETDDDHEKAE
The following text describes a protein:
Function:
Member of at least 2 two-component regulatory systems Hik2/Rre1 and Hik34/Rre1. Responds to hyperosmotic stress, regulates expression of at least 24 genes including dnaK2 and hspA with Hik34 and sigB (sll0306), sll0528, slr1119, slr0852 and ssr3188 with Hik2 (Probable). Responds to salt stress, regulates expression of at least 24 genes including adhA, dnaK2 and hspA with Hik34. Binds the adhA promoter. Phosphorylated by Hik2 in vitro. Phosphorylated protein has 10-fold higher affinity for DNA than unphosphorylated protein.
Sequence:
MAEPISLLLVDDEPGVRESVQAFLEDSGDFKVDLAANATEAWDYLQHHLPALVISDIMMPQVDGYQFLQKLREDARFQSLPVVFLTARGMTGDRIQGYQTGCDAFLSKPFDPDELEAIVRNLLARQQASSDAGSESAKLQEIYQEIRALKEQIGQPSGIHTTPSPIKLDFTPREQSVLDLVSQGLMNKEIAAQLKTSVRNVEKYVSRLFTKTGTNSRTELVRFALQHGLTE
The following text describes a protein:
Function:
Transcriptional activator. It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles. Required for the maintenance of spermatogenesis. It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade. May also play a role in the early development of embryos.
Subcellular Localization:
Cytoplasm. Nucleus, nucleoplasm.
Sequence:
MRRRPPSRGGRGAARARETRRQPRHRSGRRMAEAISCTLNCSCQSFKPGKINHRQCDQCKHGWVAHALSKLRIPPMYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSIIIPPSTANVDIRAFIESCSHRSSSLPTPVDKGNPSSIHPFENLISNMTFMLPFQFFNPLPPALIGSLPEQYMLEQGHDQSQDPKQEVHGPFPDSSFLTSSSTPFQVEKDQCLNCPDAITKKEDSTHLSDSSSYNIVTKFERTQLSPEAKVKPERNSLGTKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRNSLNLASSENYKCPGFTVTSPDCRPPPSYPGSGEDSKGQPAFPNIGQNGVLFPNLKTVQPVLPFYRSPATPAEVANTPGILPSLPLLSSSIPEQLISNEMPFDALPKKKSRKSSMPIKIEKEAVEIANEKRHNLSSDEDMPLQVVSEDEQEACSPRSHRVSEEQHVQSGGLGKPFPEGERPCHRESVIESSGAISRTPEQATHNSERETEQTPALIMVPREVEDGGHEHYFTPGMEPQVPFSDYMELQQRLLAGGLFSALSNRGMAFPCLEDSKELEHVGQHALARQTEENRFQCDICKKTFKNACSVKIHHKNMHVKEMHTCTVEGCNATFPSRRSRDRHSSNLNLHQKALSQEALESSEDHFRAAYLLKDVAKEAYQDVAFTQQASQTSVIFKGTSRMGSLVYPITQVHSASLESYNSGPLSEGTILDLSTTSSMKSESSSHSSWDSDGVSEEGTVLMEDSDGNCEGSSLVPGEDEYPICVLMEKADQSLASLPSGLPITCHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHKSLASSPSHLQ
The following text describes a protein:
Function:
Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (By similarity). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (By similarity). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (By similarity). KHDC3 ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation (By similarity). Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (By similarity). Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks (By similarity). Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (By similarity). May regulate normal development of learning, memory and anxiety (By similarity). Capable of binding RNA (By similarity).
Subcellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Core component of cytoplasmic lattices in oocytes (By similarity). Expressed in the subcortex of oocytes. Located throughout the cell cortex of ovulated eggs in a complex with NLRP5. After fertilization, restricted to the apical cortex and excluded from regions of cell-cell contact. Localized to centrosomes during interphase and mitosis (By similarity). Localizes to sites of DNA double-strand break repair (By similarity).
Domain:
Contains 1 atypical KH domain, which is still capable of binding RNA.
Sequence:
MDTPRRFPTLVQLMQPKAMPVEVLGHLPKRFSWFHSEFLKNPKVVRLEVWLVEKIFGRDRERIPHVQGMSQILIHVNRLDPNGEAEILVFGRPSYQEDTIKMIMNLADYHRQLQAKGSGKALAQDVATKKAEIQLSSTEVREAGTQRSVEVREVGTQGSPVEVRETGTQQSLEAANQSGTQRSPEAASKAVTQRFSEDTRAPVTRL
The following text describes a protein:
Function:
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular Localization:
Nucleus.
Sequence:
MTTMMTDSGTASDSGAGLVDSTRNDTTTTTTTTTTPGDNDADDDNTNGTTTGHHDNNETDNNSKSYSSTHHVPAIDNTSTTNANDNEDAAGFLDRDQSPLSSISSPLSEPDNFEFDTEPIPSILSPKSTTSDNHARDGETPELDEDGQPPAKRRRVRETTPHNHSRKPKPESPPWKKFEAEGPTTIITEDGRRKSGRVNPVLLGMKPSDKKVTRKAIQTSPVSNKSSASTSRKPAPASSSNSKHAPAKMPPPPPPPKAPARKSATTHETRPSASRSRRRSPSPRRPATPPKPAAVGTRRSTRQALAHSRASYDDGQLSPGASRATPRIKLKVRPPLTVIPLVHPNQANVRPKLGPTFEEYFARAHEIPVEEGGQHIPDEEPKYTDEMALQDAKVILRVEKEVEPGGLLAPDRCSAFEPEAEEEPPRQWAHLDHLTKAMTNFRKLMYREQQLHMQAAKRIAIACEAEWRRRNPQPKTAEEIELEEMEASKAKWRQVIRAFAGTWENVRVEVNRRRLVEWEAEEQRRVKAALNQAVNLSEQKLQQRQAQVDGDEITDEDEDEDDEDLASGMPSVMGDEKESDEHSDQGSDEMSDENDEDEDEDNMSSSEDDDKKSTASDEGLTQEELRAKYANLPTLGTTDETEETTKDVEMADAPAAMDGSVANDDDTSDESVDMDDDLGSSEESDDDEEEEEDDEEEEESDDEPAGLLGLFFGKSELKKLKEEAVTEEPSVEPAGDVEMTDASAALRPELQVNGHAHEAPITNGTHTNEQLASSQTEGADDEVSLLVIPNDEIAAENTQTAAEPGSGVVEKDFLTNDSSLKYPNEIVQSENQTLPAKESVEAGGDLPMVDAPSTDDLQRETAAAPSLEAPPNTRHDSQETVAATDMQSQSQTQSPKTTDTKPTDVDTPHSELAVSVQKPDSRQSSPQPTTPTVKTEIPFLLRGTLREYQHHGLDWLAGLYANNTNGILADEMGLGKTIQTIALLAHLACHHEVWGPHLVIVPTSVMLNWEMEFKKWCPGFKILTYYGNQEERKRKRQGWNNDDVWNVCITSYQMVLQDQQVFRRRRWHYMILDEAHNIKNFKSQRWQTLLGFNTQARLLLTGTPLQNNLTELWSLLYFLAPPENGEGGFVDLTEFHNWFARPESQILESGREQLDDEARAIIAKLHKVLRPYLLRRLKADVEKQMPAKYEHVEFCRLSKRQRELYDGFLSRADTRETLQSGNYMSIINCLMQLRKVCNHPDLFVDRPIMTSFRMSRSVPADYEWKEKFIRNRLLATKPMTTVNLSFLNMIPTEYEDLSKTHTDRIAQLSSHRILLDLREAQKVRANNAYTALDPSSVKSNLVYLESAARWGRFEELQHCVYINALRRQQRPIYGKRLTEFLTLDTHLRPYKPRPRVPAKIMSWFEEDSFLLHNAIPTLQQRAESMEMTITKFACVTPAVVTGPEMNRFLLGERGIQLFEDLDLKLSAPVKYAPYMPPQPPPDPWHEARMRLTIQFPDKRLLQYDCGKLQALDKLLRKLQAGGHRALIFTQMTKVLDILEQFLNIHGHKYLRLDGATKVEQRQILTDRFNHDPRILCFILSTRSGGLGINLTGADTVIFYDQDWNPAMDKQCQDRCHRIGQTRDVHIYRLVSEHTIEANILRKASQKQMLDDVVIQEGEFTTDYFNRLSVRDVLGSNGEVIASNEDDVAANLAMDRVLGGPSTTGAGGYDGTADGGGGASQPPVRNVGRVLEMAEDREDVDAAKAAEKEIMQDEADFGEAGSTRPGTPGDGLADLDGQLLGGEENKEVEDEVIEYNAWGERMHTIDEYMLGFMAKALEGTPLELPRDRKKGRDRNRNRKGKDSRKR
The following text describes a protein:
Function:
Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKFRLAVVQLHVSKIKADNLGRAQTLVKEAAGQGAKVVVLPECFNSPYGTGFFKEYAEKIPGESTQVLSETAKKCGIYLVGGSIPEEDGGKLYNTCSVFGPDGTLLVTHRKIHLFDIDVPGKIRFQESETLSPGKSLSMFETPYCKVGVGICYDIRFAELAQIYAKKGCQLLVYPGAFNMTTGPAHWELLQRGRAVDNQVYVATASPARDETASYVAWGHSSVINPWGEVISKAGSEESVVYADIDLQYLADVRQQIPITKQRRNDLYSVNSVQEG
The following text describes a protein:
Function:
Required for 60S ribosomal subunit formation and pre-rRNA processing. Required for normal accumulation of 25S and 5.8S rRNAs.
Miscellaneous:
MISCELLANEOUS: Present with 5890 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus, nucleolus. Note=Accumulates in the immediate vicinity of the dense fibrillar component of the nucleolus.
Sequence:
MSNHSEAYGSRDQRREKYTQGKEFEDGTLETLESIISAVEDETLSKDYQPLIVFFQRGFGAQLVQTWSYYAQVNNHGKFSKTTSLLTKTLRVLSSDTSTVTIGSGLIRLILTDYTKVLYRGLNNMRAQLTNPILRLLKQIVNFNNGQHIEELVSYFDFSLPILPRLLVPSKSELANGNSSADSSKHDSLRFTFIKFWLTLISNASPFVRKELLTENFKIMSNLFKFMNKADSDKLSEHILSVFINDILKEKSFKRTTKTKILNELAASKIHHFYYSSNKNLVKKANEFFLTFGASRDFSVAFPDNCVWFKNSVADGASHGAPITVNQVEFQIHNKLLFNTLRLFKPWEDTLQLGTLIKILENVPELVAPYSIFLTTNGNYDPKMTSYWFGITLLINKIINLKIPQFMEKVDSNIPPATSLVIENILPSLLTKSSLVKSLQFETPIIRQLACQSIVLALKKLEKVSTFYDQKGWRNEKTILLNEFHTRIPDLPIFVSTLSNSLASNKDNRILPLSISIIFNYYSKMFPNLFSINLPSSNIYTDIMQKSKISGIEFAILDNYLQFQEFNSTQTRWWNPSSGGNSLFTLLLKLASSKNASNVITTRISNLLDELTRTNVIFNISLISPVMALVNSLQGLSLQVSEIDNMEQVWKWFDETISRVVKTPYKYVDMAKEYNYISPFIMCLSEQWKYVDKSGNPEFLIKWLILFLRNMIFIGEDHIGIDKLVKNVFPEVSDHDVNIYLKLDSFEENIKKTNSSNSLISSMKSSSFFQYISALPSKNLMNISRLPVNKLDAAGILFRVQLLVEDDSVVYDNWFEATACELTGKIASYMVTDTEFPIIKVLERYINFALPKLAIEKRNALLMKKSRFMCNLIGAVCFETGHQLVEFREIIQKVVFSGENVEEYANYNELYQKEDVNAFLTSVSEYLSTSALTSLLMCSTKLESTRNILQKLFNEGKTIKISLVKNILNKAANEDPASIKEVNISLAKFFEENKVCVDASSDPMGKLSLSETTSLINSFVSSDLNYLVLKAFYRWEHFSFPSFIPSIWRIKDSPLLSIVTTAALFKHMQDKDFSAFAHETISKYGNEIAKSTYTTSKSEIFDEILNMITTYIDFYDETKRNEILKCVLSQSDHKYHAATVRYIAAHNNFTYPGVETWLHKTLLYLTKYLSERKVISNSFFELLRAMAELLKLEEVPNKLNVKIINSQLEAILGSEWIKQIKVLEYVIVLIFCVSKKSIQSQRMVQLLLSNDSYSSIMIKDNDEDSSYRKFLSTMILFSLFSIDPVVNSTPIVQEKLLTFYSGTISSNDKLILKILETIESHTATSWTNMIFSWEFIKDEEEEILEAIGDTRLITKEREGLILTLQKNMIKKSIDRYVLERPQVPELYTDSNTNNYDATTRCDLVKKYYDDTERSGVDMYDPLFLLLLIIHNKELVKMVKDDEGNVTYRYEFENFLDCKIFQFIICSLSDCHTVANISYEHLSNLASSLEKKTAQMNLEKQITSKDNERKESDSDLIKYNSIYQVLIKRILYQRQQNQDPINPLIWFSISRIVDLLGSPTAPLHEKAYRWVLSNSTIRSWDIPMVSDVMMSYNKRQQDDNKKEIDMEIYYGELSWVLTTICKGIKTDEDYKMLEKKGVFEWLLNLINMPYLKERLRELIYFIFYKVQRVADDGGLNLISRNGIVSFFEVLNNNIKSRLPQDDILNNIGTLRNENRGTLNTTLRLAQEQNGIEKLLLGYNELVKSQKRLILWTEGDSDNVVKRLRK
The following text describes a protein:
Function:
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular Localization:
Mitochondrion.
Sequence:
FDFMRGMSPCFHVNGNNIDVIETPCDFYDALVLGANSAKTRIALAALYLGTGELETLFVDSLHRALERRLSDSEFLELDVLLDFVKGQRGETNSLTMLKPLAGFSNKVCISLFRSPMFRGLWKRLLPARSNEILGLFHIKVFVFDNDVIVSGANLSGQYFRNRQDRYYKIKGSKNLADYFQGLIKTISLFSYHLQTDDTELRNSLLQFTGPYNVPKRANSTPRSIFIAPANFWAYIRQFGLNIKQTDKTNEEDFVELHHHDDRDVEDTLIFPTIQLGCVNIRQDEEVTNMMLASFPANSRACITSGYFNVTDDVTAMIAGGVATFEIITASPGANGFLGSGVFSGYMPQMYCSLVKNFFELLVKTGRSCKVKLWEYCRKDWTYHAKGIWYYPPNALFPQLTAIGSSNLAIRSMQRDLEAQLYIVTYNEKLMKKMHKEKCLIMNESSLITNETFKESRYNVSAWVTSVIDIVKRYC
The following text describes a protein:
Function:
Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization.
Sequence:
MSNNSKSPPNEQHQQQPHPPDVLVQLTESFQHFFQSLSPQYQSMTSLPSINKDSYTSVGSAPTTNNNSNSNSNSNSSNRSLNNSGSSNSGGGGSNSNKKVNNNNNNNNNNNNNNLQSPTQSQFPYHYQYSSKALHDFEEKRKLLIEQLKSVKINLDTQCDDDPISFIKIRMELTKVKTSLETELKSLDELLHTTSEVEEPNPTPIDSITSLLTMIMPSSISNSVTNNTPSSATPLTLSNNNNYTSSSLATSPTTNSSSSSSSSSSSSSTHYYNSSISSNSLSSNLPPSSIPILNTSNNKNSYPNSIIPQGTPLDNPDPNLPRFPQRDHISVKLYVDCDDYFAASAQAIENATREVFITAWFLSPEVYLIRFPSLDERYRLDNLLKRKAMQGVKIFIILWDETKIATFKGSKRAKDKLEELHTNIKVIKHPPIIPIYWSHHQKTLIIDQEIAFVGGVDFCFGRFDTWCHHLIDVNSTLWKGKDYYNPILGDMGDILVPFEDSVDRKKIPRMPWHDVMAGVNGLAARDVALNFILRWNHHKDDYYPQLYFDTTPLSPVGTSQCQLLRSMDEWSGGGRIERSIHTAYVQAIEDANHYIYIENQNFVSTHAPNVWNQISFEIVKRIKRAIRKKEVFRVFIVIPCQQDGKVEETQIKGLMHWQYSTIIRGENTIMKLLRRDCPDVDLTEYICFLSLRTHAFLEGTFVTEQIYVHSKLMIVDDRTIIVGSANINDRSLIGERDSELAFIIRDEIDTIQTKMNGQDYIASRLVFNFRLRLWKEHLGLLPQINYPPHDQINNDINNIVNLNNNNNSNINNNINNNNNEINNNNNNNNNNNSNEINNNNSDGILNNSNSFHHGSVSDNLPPLNPSSNLNSSNKKLPTTTTAAAAATTTTTTTTTTTTTNGTGTTNKQKTSHHRSNSFQGLVLQSPGSNRSNLSSPQDSPQDSPRLKNLAEEISPPPTEQHQHQSPITDINLILENVDTIIHSNEQLPPPPSSTTPPPPPPPLTTTDSVIIEDYKSDGGNLNIENNNSNNTILTNAATSMNNSTSSLSSTSLPTTTTTTTAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPSQQQQQQQQQLSQQQQLQIKKKRSSISPSTSSNKLLLSGNGSGDSIRVVTDSGSSPRGQPRSMSSLHDHADSSYCQKSNIDLIDPTCSDFYFGVWIATAASNTRIYDTVFPAIPKNSIKTCEQFAQLQKIPVSLADSKLLSEVRGNLVFHPLDFLEGEDLQPSFLFTDDLFQ
The following text describes a protein:
Function:
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (By similarity). Involved in the control of root hair growth through the regulation of syntaxin SYP123 expression.
Subcellular Localization:
Endoplasmic reticulum membrane.
Sequence:
MEGEKLIEDRGFLAAPLTFVVVVVFQLLSKWLDQLKKKGSKNTRESELRTEIKQLLREASALSQPATFAQAAKLRRSAATKEKELAQYLEQHHKEIKLSYDMYGKGLLASKVVIYLILVLCFWRTPIAIIAKQLVQPFGTLLSWGTGGHMTGHVMVGIIPWLILSNRVSKYVCRFVEF
The following text describes a protein:
Function:
Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Covalently-linked GPI-modified cell wall protein.
Sequence:
MQFTHLVALALALATSEAAHQGFNYGNTKSDGSAKSQADFQAEFSTAKNLVGTSGFTSARLYTMIQGGTANTPISAIPAAITEQTSLLLGLWASGGNFANEIAALKAAIAQYGDDLAKLVVGISVGSEDLYRNSVDGVKANAGIGTNPDEIVSYINEVRSTIAGTKLSGAPIGHVDTWTAWVNGSNSAVIDACDWLGFDGYPYFQNTMANSISDAKALFDESVAKTQAVAKGKEVWITETGWPVSGKTENLAVANLANAKTYWDEVGCPLFGKTNTWWYILQDADPVTPNPSFGIVGSTLSTTPLFDLSCSASSSSSAAAAASSTAGPSASSVIGGKASGFTTAAANSAKPTFTVGKGPGGSYNGTGFWNSTSSARPSSSAISGSSSGSAAGSSGAGASGASGQSSSSTGSSSAPSTSNILSNAASGLSGSIFGAVVAVCLALAAL
The following text describes a protein:
Function:
Plays a role in the regulation of phosphate uptake.
Subcellular Localization:
Cytoplasm.
Sequence:
MAASLSQQINNPERSYFEQALKRVEQDVLRMGALVEESFRMSHQALFENRLETPLKIAELEKEIDRLYRHIEQECASFLTLQAPVAQDLRLLSAIMQLVRDLERIGDYAQDLGEIAMKLTRYPPHPCMDEIAAMAWQAQHMLDQSLVCLTQLDPNAGEIVKKMDDVVDDAYDRLYKTLAFQRDIKGVVEPILLMALVIRHLERMADHATNIAQRVSYIVTGKRE
The following text describes a protein:
Function:
Catalyzes the oxidation of D-lactate to pyruvate. Electrons derived from D-lactate oxidation are transferred to the ubiquinone/cytochrome electron transfer chain, where they may be used to provide energy for the active transport of a variety of amino acids and sugars across the membrane.
Subcellular Localization:
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=May bind the membrane through electrostatic rather than hydrophobic forces.
Domain:
Contains 3 domains: the flavin adenine dinucleotide (FAD)-binding domain, the cap domain and the membrane-binding domain.
Sequence:
MSSMTTTDNKAFLNELARLVGSSHLLTDPAKTARYRKGFRSGQGDALAVVFPGSLLELWRVLKACVTADKIILMQAANTGLTEGSTPNGNDYDRDVVIISTLRLDKLHVLGKGEQVLAYPGTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNNSGGSLVQRGPAYTEMSLFARINEDGKLTLVNHLGIDLGETPEQILSKLDDDRIKDDDVRHDGRHAHDYDYVHRVRDIEADTPARYNADPDRLFESSGCAGKLAVFAVRLDTFEAEKNQQVFYIGTNQPEVLTEIRRHILANFENLPVAGEYMHRDIYDIAEKYGKDTFLMIDKLGTDKMPFFFNLKGRTDAMLEKVKFFRPHFTDRAMQKFGHLFPSHLPPRMKNWRDKYEHHLLLKMAGDGVGEAKSWLVDYFKQAEGDFFVCTPEEGSKAFLHRFAAAGAAIRYQAVHSDEVEDILALDIALRRNDTEWYEHLPPEIDSQLVHKLYYGHFMCYVFHQDYIVKKGVDVHALKEQMLELLQQRGAQYPAEHNVGHLYKAPETLQKFYRENDPTNSMNPGIGKTSKRKNWQEVE
The following text describes a protein:
Function:
Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE. Has no activity against Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition. May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN.
Subcellular Localization:
Secreted. Note=Secreted in hemolymph.
Sequence:
MQPVRFGSPWIMAIGLVLLLLAFVSAGKSRQRSPANCPTIKLKRQWGGKPSLGLHYQVRPIRYVVIHHTVTGECSGLLKCAEILQNMQAYHQNELDFNDISYNFLIGNDGIVYEGTGWGLRGAHTYGYNAIGTGIAFIGNFVDKLPSDAALQAAKDLLACGVQQGELSEDYALIAGSQVISTQSPGLTLYNEIQEWPHWLSNP
The following text describes a protein:
Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Sequence:
MEKPQKTEEEQPPCPQGAAPDGGWGWVVVGALFVISALVFGLIRSLGVFFVEFVQYFDESAQAVSWITSIGLAMQQLMSPIGAAASNVYGTRPVVMIGGFLSGLGFILASQATSLLHLYLTMGLISGLGWALVFTPTMASVMQYFTKRRSLAMGLGFTGVGLASFAFSPLFQYLVEAYAWRGALLILGGLSFNMVACGALIRPLGTPKVAVKTENSTKLNKCSFLLSRIYECFELSLLTHRGFVTYAVAITFFNAGYFIPYVHLVAHSRHIGFTEYQAAFVISITGVADIVGRVASGWASDLGKIRLLHMLVVWTGLLGLSLMLIPVAVVYAGLLLVSIVYGFCAGAMAPLAFAVVPEIVGIERVLGALGLLQLIESAGGLLGAPLSGWLKDSTGTYTVSFIAAGSFLMIGMLIAMTLPYFWSCTAPPAPSPSKKKSQEGSAEDGLIGESTSSNAINETLCSVDHIPYSDEEVKVCLSNDATHSVQEQEEIPQEMTHRSNFA