lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Degrades oligopeptides in a sequential manner.
Subcellular Localization:
Cytoplasm.
Sequence:
MGVTQPAAPAYLRFPHPHGELVAFTAEDDVWLAPLDGGRAWRVSADNVPVNHPRISPDGTKVAWTSTRDGAPEVHVAPVEGGPAKRLTHWGSIRTQVRGWTADGRVLALSTYGQASLRRSWARALPLDGGPATTLPYGPVGDVAQGPHTVLLSAPMGREAAWWKRYRGGTAGKLWIDREDDGEFVRLHDGLDGNIEYPFWVGDRIAFLSDHEGTGALYSSLADGSDLRRHTPVDGFYARHAATDGSRVVYASAGELWTLDDLDGAEPRRLDIRLGGARVDLQSYPVNAARWFGSASPDHTARGSAVAVRGGVHWVTHRSGPARALAATPGVRNRLPRTFRVDGEEWVVWVTDAEGDDALEFAPATGLAPGATARRLAAGQLGRVLHLAVAPDGSRVAVASHDGRVLLVERESGEVREVDRSEDGDASGLVFSPDSSWLAWSHPGPEPLRQLKLANTTDLSVSEATPLRFKDYSPAFTLDGKHLAFLSTRSFDPVYDEHVFDLAFVEGARPYLITLAATTPSPFGPQRHGRPFETPDREETPDSEGTPTTRIDIEGLADRIVPFPVEAARYSRLRAAKDGVLWLRHPLTGVLGASRANPEDPDPNTELERYDLAQQRVEHLGGDADHFEVSGDGKRVLLWTDGRLKVVPSDRRASGDEDSDTNITVDLGRVRQTVEPAAEWRQMFDETGRIMRDHYWRADMNGVDWDGVLDRYRPVLDRVATHDDLVDLLWEVHGELGTSHAYVTPRGGHGSGARQGLLGADLSRHEDGAWRIDRVLPSETSDPDARSPLAAPGVAVRAGDAIVAVAGQAVDPVTGPGPLLVGTAGKPVELTVSPSGGGEVRHAVVVPLADEEPLRYHAWVADRRAYVHEKSGGRLGYLHVPDMQAPGWAQIHRDLRVEVAREGLVVDVRENRGGHTSQLVVEKLARRIVGWDLPRGMRPTSYPQDAPRGPVVAVANEFSGSDGDIVNAAIKALGIGPVVGVRTWGGVIGIDSRYRLVDGTLITQPKYAFWLEGYGWGVENHGVDPDVEVPQRPQDHAAGRDPQLDEAIALALAALEETPAKTPPSLP
The following text describes a protein:
Function:
ABC transporter that may affect phytic acid transport and compartmentalization. May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
WLFSWIYYGQDGGGPVTCVQRSLVDCVNVVLLVAYASSLLAACARGQWDGIRWGRRRRKVAGAAVSVCCVAVSATYAVTGFRDAIDAAASIVRGLVWVAVAASLHVQPTRPARTVALLWWTLFSLLITAYNAEVLVSGHQLDLAEAVAWPSHAHRGSLENGDSLSEPLINKTVHHSELYRAGLFSQFTFSWLNPLLRLGRSKALELAEVPLTGSKDSALQATQKFSEAWNSCWPRRTNSLALVLCKCFLREIMIAGFYAFMRTLYQEERYLSVGLSLVGCLLFIKLVESLSQRHWFFDSRRTGLRIRSALMAAIFQKQLKLSSHGRKNHSTGEIINYIAVDVYRLGDALTWLHMVWSSPLQLAFTIGTLFWVLGLGALPGLVPLVIFGFLNVPFAKLLQGYQAKFMVAQDERLRSTSEILNSMKIIKLHSWEDRFQNIIESLRKTEFKWLRETQMKKAYNAIIYWMSPTVVSAVMYTATAILGSAPLNASTLFTVLATLRVMAGPLRLLPEILTMMIQYKVSLDRIENFFVEDEIEDGVERVPHHDNSDIRIHVQDGNFSWNASGADLALRNVNLKVHQGEKIAVCGSVGSGKSSLLYALLREIPTRSGSVEVFGSVAYVSQNSWIQSGTVRDNILFGKTFNKALYEKAVKSCALDDDIANFDNGDLTEIGQRGLNMSGGQKQKIQLARAVYSDADIYLLDDPFSAIDAHTAAVLFYDCVMTTLSEKTVVLVTHQVEFLTETDRILVMEGGQVKQQGRYAELLESGTTFEKLLTEEEDKGIGDLGWKPYKDYIDVSKGMLPLCGLCTTQVLFTSFQILSTYWLAVAVQMNASTALLVGAYSGLSIFSCCFAYLKNLFAATLGLKASKAFYTSLMESVFKAPMSFFDATPVGRIFTRASSDLSILDFDIPYSMSFVITGAVEVVTIVLVMSFVTWQVLVVAIPIAITMAYVQRYYVASARELARINGTTKAPVMNYAAESILGVVTIRAFAATDRFMINNQQLIDNDATLFFHTAAAQEWVLIRVEALQSLTIFTSSLFLILVPPGALRVFASPMLLTSAQVFLTRFYSYLENYIVSVERIKQYMHLQSEPPAVIPDNRPPISWPQEGSIDPQDLKVKYRPNTSLVLKGITCTFPARSRIGVVGRTGSGKSTLISTLFRLVDPVGGRILIDNLDISSIGLKDLRTKLSIIPQEPTLFRGTVRNNLDPLGLHSDDEIKQALEKCQLKGSISSTAGLLDTVVSDDGDNWSVGQRQLFCLGRVLLHRNKILVLDKATASIDAATDAILQSVIRKQFNSCTVITIAHRVPTVTDSDKVMVLSYGKVLEYDTPAKLLGDKKSAFAKLVAEYWANCKRNSR
The following text describes a protein:
Function:
Modulates the antiapoptotic activity of the viral protein BHRF1. May also play an active part in oncogenesis in Burkitt's lymphomy and nasopharyngeal carcinoma.
Subcellular Localization:
Host cytoplasm.
Sequence:
MNLAIALDSPHPGLASYTILPRPFYHISLKPVSWPDETMRPAKSTDSVFVRTPVEAWVAPSPPDDKVAESSYLMFRAMYAVFTRDEKDLPLPALVLCRLIKASLRKDRKLYAELACRTADIGGKDTHVRLIISVLRAVYNDHYDYWSRLRVVLCYTVVFAVRNYLDDHKSAAFVLGAIAHYLALYRRLWFARLGGMPRSLRRQFPVTWALASLTDFLKSL
The following text describes a protein:
Function:
Required for ciliogenesis.
Subcellular Localization:
Cell projection, cilium. Vacuole membrane; Multi-pass membrane protein.
Sequence:
MKLTIKRYRVMLALQTVLFLVDFFINIFSVLVRQNNGLSLILLIIQCACLVISLGTLFVSFFSTYAFQAGLIDLLYEKFHVSLIIFLFGITRRSLFGPPHFLSYLSAKEL
The following text describes a protein:
Function:
Inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus. In turn, associates with PilM and facilitates PilM functionally relevant structural changes.
Subcellular Localization:
Cell inner membrane; Single-pass type II membrane protein.
Sequence:
MARINLLPWREELREQRKQQFLVILGGVLVASAALVFLGDQYFTAAIENQNARNDFLRKEIVVLDARIKEISELKSRRQQLLERMKIIQDLQGNRPIIGRVFDQLVRTLPDGVYFTDLKMTGKNIAIAGAAESNNRVSNLMRNMDASEWLTAPTLNEVKAVTQGAVDQANVFQLTVQQTQPGEEDAKAKHGVAQGAKK
The following text describes a protein:
Function:
3'-5' exonuclease degrading single-stranded small RNAs.
Subcellular Localization:
Nucleus.
Sequence:
MEAKLESAKKEVLAEIVKLAQKREMKGNKGGWKDFLRSYDKKFGVSLSDPSKRSIDVLLAFLKTFTPDDLKFFDKVFQCHSNRDAVEKLQKSNPESESIEQRLVRLTFEHPQYPTDYSFPSHEKDWLVTRRSKKPKHIQSKAMVAIDCEMVLCQDGTEALVRICAVDRNLEVRLNEFVNPNKPIADYRTEITGITAGDLDGVSCSLADVQTSMKKLLSHGTILIGHSLHNDLRALKIDHAKVIDTSYVFKYQDQPSNRRPSLSNLCKSVLGFELRKTGSPHNCLDDACTAMKLVLAKVEGGVDNIIPLVREEVQETETAKLLVHRIPAAVHSQELHKVIPGDFTVEVKANKKGQADKYTAFVNFKNQHEANEAFDNLEGNQEKDTGGRPQKLISFHLDSGISGSFYVRKMEVNNYSKDTELAPKKRSFEDEEAVEGSKKPRIEDQSTELKEAGAGCNQCETQSKEIERLKKELSHRDEEISNLNKLIVNLVRKQGL
The following text describes a protein:
Function:
Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress. It phosphorylates mitochondrial proteins to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components. Depending on the severity of mitochondrial damage, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to eliminating severely damaged mitochondria via PINK1-PRKN-dependent mitophagy (By similarity). When cellular stress results in irreversible mitochondrial damage, PINK1 accumulates at the outer mitochondrial membrane (OMM) where it phosphorylates pre-existing polyubiquitin chains at 'Ser-65', recruits PRKN from the cytosol to the OMM and activates PRKN by phosphorylation at 'Ser-65'. Activated PRKN then ubiquinates VDAC1 and other OMM proteins to initiate mitophagy (By similarity). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by phosphorylating and thus promoting the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (By similarity). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (By similarity). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L. Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (By similarity). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10. Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity.
Subcellular Localization:
Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion inner membrane; Single-pass membrane protein. Cytoplasm, cytosol. Note=Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol. When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity.
Sequence:
MAVRQALGRGLQLGRALLLRFAPKPGPLFGWGKPGPAAAWGRGERPGQVVSPGAQPRPVGLPLPDRYRFFRQSVAGLAARIQRQFMVRARGGAGPCGRAVFLAFGLGLGLIEEKQAEGRRAASACQEIQAIFTQKTKRVSDPLDTRCWQGFRLEDYLIGQAIGKGCNAAVYEATMPTLPQHLEKAKHLGLIGKGPDVVLKGADGEQAPGTPTFPFAIKMMWNISAGSSSEAILSKMSQELVPASRVALAGEYGAVTYRRSRDGPKQLAPHPNIIRVFRAFTSSVPLLPGALADYPDMLPPHYYPEGLGHGRTLFLVMKNYPCTLRQYLEEQTPSSRLATMMTLQLLEGVDHLVQQGIAHRDLKSDNILVEWDSDGCPWLVISDFGCCLADQHVGLRLPFNSSSVERGGNGSLMAPEVSTAHSGPSAVIDYSKADTWAVGAIAYEIFGLANPFYGQGSAHLESRSYQEAQLPEMPESVPPEARRLVRSLLQREASKRPSARLAANVLHLSLWGEHLLALKNLKLDKMIAWLLQQSAATLLADRLREKSCVETKLQMLFLANLECEALCQAALLLSSWRAAP
The following text describes a protein:
Function:
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MPSNTHKNRGGGRGKGCKPRRLGTSRPQKDISHYQSDGFNIDRPGSLVKTQEQETQIQLELDQKKIHDQLNGLQLDSNDQVKIEFPVAMWDFDHCDPRKCTGKKLGRLGLMTELRVGQRFRGIVLSPEGTIPVSPGDLEQITKHGIAVVECSWARLEEIPFSKIRTTGDRSLPYLTAANPVNYGKPYKLTCVEAVAGSLAIVGLQAQAELLLQKFGWGHAFWSLNQDLIQKYRACEDSQAIQSVQEEILETIEEEARERRRTPEDDDLLVPNPNHINHHLDDDEEDEDSSENDETRSDPE
The following text describes a protein:
Function:
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).
Sequence:
MDAPSDLCYAPVHTAGLGAKLCAELTEPPDVVIHAAAERRTDVVERDPQTVQKLNVGATAVIASVCEKLGILLIYISTNYVFDGTKPPYKPSDAPNPLNKYGQSKRDGEIATLEHYPRAVILRLPLLYGSIERLNESAATYLLHQIQDTSKVQDLCDYQQRRPTHVRDVASVLLQLAQRHCKGERVSGILHWNTSEQLTRYQMALIITDVFNLPRIISSQTRIPLLLARHAPTMHPWTSQL
The following text describes a protein:
Function:
Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.
Subcellular Localization:
Apical cell membrane; Single-pass type II membrane protein.
Sequence:
MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSPAPQDLDLEILETVMGQLDANRIRENLRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAGASTYEVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNGTLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQTVVFSATKEIRSPGPGDLSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFIHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFLQAAQQDLGALLEQHSISLGPLVNAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATLRPVADL
The following text describes a protein:
Function:
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Subcellular Localization:
Nucleus.
Sequence:
FLRKPTEAGRFSLDAERKFHHDRSAMSCFCPPVRNNRLLYTLDLNDGYNTDRFIKRDENVKEKLDNMLHWLLLNKNRFVTDERRANKTNVIGAYPDFVLWRGHLSKMMCTPFEKREGWEMAIQKMGKTIYISEVETVEAMAKRANLSERERLMTYWGVRFEGYMTGNFPKPGQNLKPKNLMESKQTVTNTNTAFCSVLRSRLNSRHSLIYGAEVDCCLPVEVVFAPDSYVELKTSRMFDSFRQENSFYKFKARKWWAQSFLAGVPQITCGFRDDRGFVTELCDFKTLELPSKTDAWNSQTCLVFLDNILQFIKEMSQDTNAHSVSKVALLKYRPQEQYILYEVSDSKEFCFLPDWFVKAMRDL
The following text describes a protein:
Function:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Subcellular Localization:
Cytoplasm, cytoskeleton, spindle. Nucleus.
Sequence:
MGSEIDQNDTDSSTQEWYRLLVVEKSTTLSDFMTSKRTKMVSDFPEEREEAIEEIIEVISTFPMDFLQKDEVSLLLNYFINSIESSALTGGAVIRGVHHLILKSKNLPDNFEVSLIRVLFKEGNVQSWAQKERQLQYEILIWFLKYRLSFLKGLGPDFLATFMKSVSGERDPRCLVHMFSAFLEVSNNFTLGPFTEDMFETIACYFPVEFKPQKTDTITREYLAASCASCLVSSPSFAPFCFLFIDEKLNDDDCSDEEYEDVLNLLILAYNRFPAQKKNLSLIEPLIGGIRKIGLNPKNKGEMQKYVSQAFEAVIKLCTKSSETNSKALDGIVSSIVEDSEPFVLQAEMGLCKKALTLLRSAFKSLPDKNSRQIFNQVIAWILNLIQGDSVNAAGNRADIVQEGLEYLVEWIQLASEYKELSIETLAVFEQSIFESCSRAREFKPREAITAIYECASVYFESDCASDELISQCRSYIALALRTPIDTDSDFQSLLKLIRIYSSKNFDQVEIILADNETNSWNAMKVLPVLCAISCSQRWNLLKNKIVDELGSTISSSTEISYLICYVQMMEKCKKDPQLFHQQFEVFESVLYKTDCNEPVSVSYLMQSISLLLSEDDHQKFMNQTTTRYQSLEGSSLDNFNQKYRLAYLQNKNTNDLKTIANLKLPERTIRQLFFAICNREAENENNSEIPEQHHIAEIKAKLLRNAPNSLSAFEQFLTNISGSTESPFEYLLDFDSFDSNPDRCRYETASPLWRQRIFCQIVPIFKRKFEEPGSQKHVLVEMLPHLLTFAVPLDFQQLKKQFAMLLPVLIQTIGMEDVIPSHVTRTIPMFLTISEPLQPKDLGTVVKYLCSITRDNDSNMTNLEDALNGLNILARRQPPKSLHSEVPLVVTSINKILGHKKRLLRMMAADVKNNWEMVITK
The following text describes a protein:
Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Subcellular Localization:
Nucleus.
Sequence:
MSLETLLQAAEWLELRAQTGAREGEEKSEKPEPCGINGDSEEVTSDASESQKVEERELKQSLSPSSSQQSEEEKDGKRRSGGYGTREVHNKLEKNRRAHLKECFEVLKRHIPNMEDKKTSNLCILRSALRYIQALKRKEKEYEHEMERLAREKIATQQRIAQLKMELREELDNQEKPPPWTQDDDQASTSTASEGEDNMKINEDEEEKLWHPTALTSSVGGATASVPMDVCTTLLPTKDTPSYTILKKPALQPYTIIKETSPFRVLKKDHVTASSTTATENAPSTASKQTSAGSPILPPKKANVSYTIFKEVLPSHTVVGKTTAPYTVVKETTSSYSLVRGTAPYTVISKTTIPSVTIKEPSPLYNHVKAATVPYTIIKDGTEAATAATATKRVSFSVVTEVKPTTQAVPNVIGKEKPIAASSAASSAAGPPSILRQGALQPVFVNKESTMAFQTLPQPPVEVRVALAPAPEVRMQTMVKELTANQPVTKATSLPNKAVKKTTAVGIQATPEELLERKPQEDEPPRRPGPSMASIAIQASLPSEPTKPEHLSRPSMNHTAVQAFHPSQFHVVAAHDARTEHGLHPAVSIPHLGTSHSGIGHPSLPPTQPSIANLTRMTPITLASLYNTPTVTYTTPITITPYISPTMTLTSLRPHAVPHGSLHSFIPPTIIPTQLGGTAAAAIPLSITTQRLPMSAPLLPATIARMALPANSLSSHISPVTMTTRFSPVPVSANVHPAVHPAMAKPPGQAVAGQTMAAISVPAPVLTVASFVAPTHTVTTTKNL
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization:
Nucleus.
Sequence:
MNVVSTDAASTSSASTTSTTTPFDVTNGGRIKGEGGEDHLARLANLAQGVGKEDSDSTATSTPTAADAPLYPGYMPGYTGWPQYYQQFAAQPGITPAAFSAWPAQWNGAAAMSGWPAYGKCTSEDDRALALFGIGEWDSQSKKGRQTYQRYQTSVLEQKFLQSSYVSKKQREELRMQTNLTDRQIKIWFQNRRMKAKKEKHRLEEGGEHSTLLPPTKGSIPLPHGSLPALPVGLQQLQHMQQQQPQPDGSCSVGSSIEDKDKQHGWAHMAPNPLLTHQFWPTSQTHPYAIPQYQLCPPNI
The following text describes a protein:
Function:
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Subcellular Localization:
Cytoplasm.
Sequence:
MARSKTSQRWLKEHFDDPYVKMAQRDGYRSRASYKLLEIQEKDRILRPGMTVVDLGAAPGGWSQVTSRVIGDRGRLIASDILEMDSIPDVTFIQGDFTEDAVFARILEAIGDHPVDLVISDMAPNMSGVRAADQPRAMYLCELALDLAGRVLRPGGDFLIKIFQGEGFDQYHKQAREMFDKVQMRKPLSSRDRSREQYLLARGFRGE
The following text describes a protein:
Function:
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKSDGVNLCFTLNLAVADTLIGVAISGLLTEQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPLRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGSCSFFAVFHPYFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRPPRTPSDFKAVRTVSVLIGSFTLSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYRQKEVRLQLYHMALGVKKALTSFLLFLSARNGGPERPRESSCHIVTISNSEFDG
The following text describes a protein:
Function:
Secreted protein which suppresses the host allergic response by inhibiting the interaction of host IL33 with its receptor in order to maintain parasitic infection. Binds to both host IL33 and host nuclear DNA and this dual binding blocks the interaction of IL33 with its receptor, and tethers IL33 within necrotic cells, preventing its release, and blocking allergic response initiation.
Subcellular Localization:
Secreted. Host nucleus.
Sequence:
MDIIGQVYCFTGAPHTITCLLREQFINWYIKYKRSENYPAFRELVVMYRLFLALGFLTFINAAGQRCRFTDVERDKGYTGMLLKGRLRKTAGNGRTVELICGRGNHNYTCESGVLKESSPRQARCGCKGILEMLFDMPKEERPSPMYDSVTYDPTPNTPTTVGKDGIWNGVDYRNGSTVKPYCDTGPVINGSSKAVCVSGKWVPTLGVCPKMCSIGSLKENGKFVDVTATTKGDELNPPPREQTLIPIVRKVDKDKVQHGVKVVALCKAEDSTTAAEGVQEFECDNGKWKPEPVPCP
The following text describes a protein:
Function:
Displays some glucuronoyl esterase activity in vitro, since it is able to hydrolyze methyl 4-O-methyl-D-glucopyranosyluronate, allyl D-glucuronate, benzyl D-glucuronate and D-glucuronic acid methyl ester. However, esters of glucuronic acid are probably not its biological substrate, as they are not present in the marine environment. Can also hydrolyze a range of other esters, including p-nitrophenyl acetate. More likely biologically-relevant substrates for MZ0003 and other marine bacterial CE15s are algal cell wall polysaccharides, as these would be readily available in this environment and could be used as energy sources.
Subcellular Localization:
Periplasm.
Sequence:
MQRTCVLIVLIVTSTMWTPDPDVYAQPRGFNYDEAQVPKYTLPDPLVMVDGTKVTSAKQWNDKRRDEVQQLFEAYMYGKVPDGETELIFTDAKGERALGGAAIRKQVKISFGEKEDAPAMDLLIYLPADAKVRVPVFLGLNFHGNHTIHKDKEIWLTESWVRTNKKFGITKNKANELSRGVAAGRWQIEKAIAKGYGVATIYCGDIDPDFNFPSNGIQAYYYKKDQTIPEKGQWGTIAAWAFGLSCAMDYFETDTDIDHKKVAVLGHSRLGKTSLWAGAIDTRFALTISNCSGCGGAALSRRRFGETVRRINTSFPHWFCSRFHQYNDKEDKLPIDQHMLIALCAPRPVLINSATEDKWADPHGEFLAAQGADAVYRMLGTGGLDAKKWPEPNKLVKSTIGYHLRPGKHDVTARDWDVYIEFADHHMTGGAE
The following text describes a protein:
Function:
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.
Sequence:
MELSYQALRVASQNREAEELRTEARRKNLLILIMHYLLQEGYVDSANSLEQETKISSRRFEVCDNVDLETILMEYESYYYIKFQKYPKITKKALDHDSRVQPKPRSAGKLRRAGSNSTQGLPRIGQQQVIHRPVSSSYYRTNGHQKALSRENSKQESGGNSPQEASEVGLNVSAISKASGEGSHTRRRQVIDFRSMIQDTIKGASQEIALNSLNCNPDPSERLIKPVGAFIGGNSEMRELAAVISRDIYLQNPNVRWDDIIGLDAAKRLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECNTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTGPGELDYAMLRRLEKRILVDLPSKEARQAMIQHWLPPISNSSGVELRMDLDYSTLGEETDGYSGSDIRLVCKEAAMRPVRKIFDALENHHSEHKKLPVISLETVTTSDFSEVLAHTKPSAKSLAEKYSAWQNEFESV
The following text describes a protein:
Function:
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MSIFVNKPVIVREVFADNLEYEFILIQSVLHNYSFVSMDTEFPGTIFKPDKKFVQLGNPEVNYRFMKVNVDAMKIIQLGLTLSDSEDFDIGKDHYDKESIKLLRQQGINFTKNKEKGIYSRDFGMMFLTSGLGFSALTWVIFHSGYDFGFLLKILTQHPLPPDLKSSMRHLTYYFGCRIFDIKYDFKIFNLHGGLEKVAKTLNVARVIGLSHQAGSDSLLILRCFMQIKDTKAFKQCNQKLPALALYGLI
The following text describes a protein:
Function:
Terminates transcription on the whole genome. Termination is linked to FttA-mediated RNA cleavage and does not require NTP hydrolysis. Cleaves endonucleolytically at the RNA exit channel of RNA polymerase (RNAP); the 5'-3' exonuclease activity of this protein degrades the nascent RNA released from RNAP; An RNA nuclease, it bind single-stranded RNA (ssRNA) with a preference for U-rich sequences.
Domain:
The KHb domain binds ssRNA better than the KHa domain.
Sequence:
MVSEMLEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITENGNLIRDIAKDIRKRIIIRSDRSVLMDPEKAIRKIHEIVPEEAKITNISFDDVTCEVIIEARKPGLVIGKYGSTSREIVKNTGWAPKILRTPPISSEIIERIRRTLRKNSKERKKILQQLGNRIHQKPKYDNDWARLTAMGGFREVGRSCLYLQTPNSRVLLDCGVNVAGGDDKNSYPYLNVPEFTLDSLDAVIITHAHLDHSGFLPYLYHYGYDGPVYCTAPTRDLMTLLQLDHIDIAHREDEPLPFNVKHVKKSVKHTITLDYGEVTDIAPDIRLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQSRLLEAAANRFPRIETLVMESTYGGHEDVQPSRNRAEKELVKTIYSTLRRGGKILIPVFAVGRAQELMIVLEEYIRTGIIDEVPVYIDGMIWEANAIHTARPEYLSKDLRDQIFHMGHNPFISDIFHKVNGMDERREIVEGEPSIILSTSGMLTGGNSLEYFKWLCEDPDNSLVFVGYQAEGSLGRRIQKGWKEIPLKDEDDKMRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPKPEKILLCHGDNYKTLDLASSIYRTYRIETKTPLNLETVRIQ
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. Pol III also exhibits 3'-5' exonuclease activity. The delta subunit interacts with the gamma/tau subunit to load the beta sliding clamp (dnaN) onto the DNA (By similarity).
Sequence:
MSEAKPLHLVLGDEELLVERAVADVLRSARQRAGTADVPVSRMRAGDVGAYELAELLSPSLFAEERIVVLGAAAEAGKDAAAVIESAAADLPAGTVLVVVHSGGGRAKSLANQLRSMGAQVHPCARITKVSERADFIRSEFASLRVKVDDETVTALLDAVGSDVRELASACSQLVADTGGAVDAAAVRRYHSGKAEVRGFDIADKAVAGDVAGAAEALRWAMMRGEPLVVLADALAEAVHTIGRVGPQSGDPYRLAAQLGMPPWRVQKAQKQARRWSRDTVATAMRLVAELNANVKGAVADADYALESAVRQVAELVADRGR
The following text describes a protein:
Function:
May be involved in the splicing of group IIB introns in mitochondria.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSIRRSLTLAKEPKDLFLFLCNLRARCVSTDDYDPPFSPLSKPTKPPKEKKKQKTKKQDQSSELVNDLKIPVISDLPFDFRYSYSETNPEIEPIGFREPKRFSPFGPGRLDRKWTGTTALASPEIDQSQWVEERARVLGETLTEDEVTELIERYRHSDCTRQINLGKGGVTHNMIDDIHNHWKKAEAVRIKCLGVPTLDMDNICFHLEEKSGGKIVYRNINILVLYRGRNYDPKSRPIIPLMLWKPHPPIYPRLVKNVADGLEFEETKEMRNRGLHSPALMKLTRNGVYVNVVGRVREEFETEEIVRLDCTHVGMSDCKRIGVKLKEMVPCVPILFKDEQIILWRGKRTGEEELVTL
The following text describes a protein:
Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.
Sequence:
MSDRSVSIVEYFGADESGHSCGYCKSPDTNFSYGIWGHQVTCQDYQDLIDRGWRRSGKYIYKPRLEVQCCKMYTIKCDAVNFKMNKSHKKIIKNFNKFINYGILPKEKKDAVDDENVHHSPPPPHHHQVQGHQMKRGDGNDDASFQGLQSDQVDKIDNEVTTATTTTTTTTSASNDDGGGDERVASDDKMELDNNADGGGGGGNSKPDGGDEADAKDGFRKQQKMTAHPKPGVGADKTKGPCKKAKLMRVERKQMKVMKLETSVVFNDRQQHHQQQQQDQQQQQQQQQKSAKMKNHPKSLEDFLGEIIEKPSHKFEIKMVAAHDDTATAADFPACHAVYHKYQTCIHNDPPSKPTTKQFTRFLINTPLLPSTATTTTPTTSVPATTTNSYKTTSASTSSEVPQGSFHQQYWLDGELVAVGVVDVLTKCLSSVYFFYDPKYSALSLGTYAALREIAFTRHLHTLTSNNNNDNIISSYYMGFYIHSCPKMRYKGQYSPSYLLCPEKYSWQPIEKCLPLIQVNPYSRLDDSSETGGEMNEEEDISDVGILYRNTLMSYLDYRTVRLRAGGRPEEEERLKLYVKLIGRELGQRMFLFRD
The following text describes a protein:
Function:
Part of a binding-protein-dependent transport system for a sugar.
Subcellular Localization:
Cell envelope.
Sequence:
MPGISRKAALAVAASASLALLATACTGQSATGASDDPNAETTITFWHGWSAPAEVKAVQANVDRFEKAHPNIKVKVVGNINDDKLNQALRAGGSSGPDVVSSFTTSNIGKFCSSGAFLDLKPFVEKSKLDLDALIPKPMLDYTQFEGTRCALPLLGDAYGLYYNKDAFEAAGIKAPPKTWSEFAQVAKKLTKTKGDGYRQLGFMPNYHGYETVVDHYMSQWDHAYFDEDGRSAVAEDPAFAEMFTYQKKLVDDLGGFEKLEKYRNTFGDEWGAKHPFQTGQVAMQLDGEWRLGMAKDAGVDFEIGTAPMPVADDEAAEYGKGFLSGTVMGIAPQSKKQNAAWELVKYMTTDTGAVVAFANAIRNVPSTFPALKSPDLKTDPEFKTFLDIAQHRESNSPPASVNGATYQLTLQDLGYQYESGKVKDLKAGLEKAAAQIDRDIEQAK
The following text describes a protein:
Function:
Has acyl esterase, lipase and phospholipase A activity.
Miscellaneous:
MISCELLANEOUS: Present with 2350 molecules/cell in log phase SD medium.
Subcellular Localization:
Peroxisome matrix. Note=Peroxisomal import is dependent on the peroxisomal targeting signal type 1 (PTS1) receptor PEX5 and on self-interaction.
Sequence:
MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFERTKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPPQNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTLEERAVMFDRAFDSFKNEALVKTTKQKL