lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative DNA synthesis in bacteria as well as the bulk of DNA synthesis/repair after ionizing radiation (IR). The alpha chain is the catalytic subunit. Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented. DNA is progressively degraded for the first 1.5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour. Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are required for its continuation. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MTVSDAPTPHIHLPDGSCCQPKKFAHLHQHTQYSLLDGAAKLKDLLKWAKEVTPEGQTPALAMTDHGNMHGAVHFYNYAMGMEVKPIIGYEAYVVPGFGTRRDRSRAQDGEKGIFHLTLLARDFEGYQNLCRLSSRGYTEGYYYKPRIDHELLQEHHKGIIAFSGCLGSEVQQLLMQGREDDARARLLWYRELFGDNYFIEIQDHGLPEQKKNNPILKAWAQELGIGMVATNDGHYVKKSDATAHETLLAIQTKATLADENRFKFPCDEFYVKNLEEMQRALPVSEWGEEPFDNTAHIAELCNVELPVGKKRQYQMPQLPIPEGRSMAEELRVQTYAGAVKRYPAHLTEGLLRDYAARSLAELGEADAARVLKRTGGCDSASCDLDTLYTLLAFLGSEWEARGKEAGEKYTPYPALEKMEQDGESGTLPAYAHADCRAARRQDSDTSIELDPDTDDEETTRSHHRYALKLLRRAEYELSVINNMGFPDYFLIVADYINWAKDHDISVGPGRGSGAGSLVAYAIRITNLDPLEFELLFERFLNPDRISMPDFDIDFNDARRTEVIGYVQEKYGTDKVAQIATFGTMASKACLKDVARVMGLEYAKVDKVSKLIPIKFGKSYSLEQAREAVPDIQQMLAEDAQLLEAYEFAQKLEGLTRHASVHAAGVVIGREELTNLVPVMRDTSGEGQVCQYDMKSVEDIGLIKMDFLGLRTLSFLDEAKRILRESGTDFEEKYGDFDHIPFDDEKTYELMSRGDTKGVFQLEGAGIADASRRLKPRRLADIIALSALYRPGPMENIPTYVRRHHGIEEVDYDKDGFPNSKQWLEKILQETYGIPVYQEQIMQIASEVAGYSLGGADLLRRAMGKKDAEEMKRQRQLFVVGAKEKGVPEDEGNKLFDMLDAFANYGFNKSHSAAYGVITYQTAWLKANYPVQFMAALLTVERRDSDKVAEYVSDARKMDLHVLPPDINRSSSDFAVAGEEILFGLYAIKGLGESAVLRILEEREKAGAFKSLADFCSRLGNKVCNRKALESLIKSGAFDAFGERHQLIESLEDALEDAAGTAEINARAQSGMSMMFGMEEVKKERPLRSSIAPYSDLERLAIEKEALGLYISGHPLEQHEGLREAASCRVSDLDAWFALQNVAPGKRQKAVLAGMIEGVVKKPTKSGGMMARFILADESGQMELVAFSRAYDRIEPKLVNDTPALVIVELEAEDGGLRAIAEEIVSIEQLSEVPKVMYVTIDLETASPDALGDFQSVLDEYAGSMPTYLRLETPEQFVVYQLDHGMGSPEAIRALNQTFAWADAHLAYDQQTILGRFAPKPPAWMNRQQGGGMRA
The following text describes a protein:
Function:
Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion.
Subcellular Localization:
Cytoplasm. Note=Enriched in filopodia.
Domain:
The coiled-coil and the proline-rich region are responsible to the binding to talA.
Sequence:
MEDDDTLNGEYFQPVEDMITLPILTEESLLLNLKMRYKKKEIYTYTGSILVAVNPYEILPIYTADIVKSYFAKSRNLMLPHIFAVSDAAFTNMIEEGKNQSIIISGESGAGKTESTKLIIQYLAARTNRHSQVEQMIVESSPILEAFGNAKTIRNNNSSRFGKFIEIQFNREGHISGARIINYLLEKSRISHQASSERNYHIFYQLLAGASDELKEKLKLGEPEDYHYLSQSGCIRIENINDVEDFEHVKYAMNVLGLPEDKQFTIFSIVSAVLHIGNLKFEKSEKTQGAEGSEVSNKDTLKIIAQLLSVDPVKLETCLTIRHVLIRGQNFVIPLKVNEAEDTRDSLAKALYGNVFNWLVVFINSKIHKPQKNSTFIGVLDIFGFENFKKNSFEQFCINFANEKLQQHFNQHIFKLEQEEYEKEKINWSKIVYNDNQECLDLIEKRPLGILSLLDEESRFPQATDLTYLDKLHTNHEKHPYYEKPRRSKNTFVVKHYAGEVHYDTQGFLDKNKDTVSDDLSSLLQGSKSKFIIELFTPPREEGDDSDKGREKKKTTAGQTFKTQLQSLINILSSTQPHYVRCIKPNTTKEPAVYDRELIQAQLRYAGMMETIRIRKLGYPIRHTHKEFRDRYLILDYRARSTDHKQTCAGLINLLSGTGGLERDEWQLGNTKVFIRDHQYLKLEELRKLKLLKKVTLIQSVWRMYRCKKRYQQIRASAKILGAAMLSHSSRRDFQEQRQAVQRIKGFFKMLTYQKQFKIIQINLRIVQNNIRSFIARRHSRNAVLLKRDRNARMLEIQREKDEEERNRQEKEERDRQEKEDKEKETADRRQLQEEQKRREEELRAKREEEELKKLEEKKSQLKELNQIDELSSLERMLKEQQDKNINELDDFVNSLEAFSFEGGVDDSQPYSFNHKMYEMSPEALDKISITDLLQGLKQTVRSVTKFEVDESKFELPPGIENVLKRAPGIKRQASSFLPGQPIPDVYSSPQYPVDEADDDDSNNNYINSNNGDLPLPTSQSSDFSLPPPPSSSSMDFGLPPPPPSSSSGGTYSLPPMPVFDFGMIDPILGAPPPPPSTSDSTSPSATATGNNTPNSSSASASQSTNQVNPQPTVSVVELPQILNDEEISLYSFYDYANKNFNIEKLKQKDDIFSYQKSHIKSSLLVHSDAEQTKVAVEIFSKVLHYMNSNPLVSKKDPADFYSPVKFILTKGLAIESLRDEIYCQLIKQSTSNPIQDLNIRVWELIHFTCSTFPPTRKLIKYFAAYLKTTIQQSDVSKSVKDSAQASYFILQRFTLNGARKQVPSVTELESIKENRPIFVRITATDGSLKGLHIDSATTCQESSNDLSQRSRMRVNSKENGFTIIESFNGIERDIAPTDKLCDVLSKVENLQATLSSKIQVNFKFVFKKKLFFDNITNNVPTTSINVENEFYYHQLFNDLFNSNYCKDQDYQISIGSLKLQFESSDYTDEIRAWLPGNGRGKYFTTDIEKNRFDDFINKYKSHKGLSPEDAKKQMVQLLEKHPLANCSLVVCEHQSESLPYPKNFVLALNVNGINIYDPATSKMLESVKYSNQSQQNLKSDDKSVSIILENKSTLQAFTGDVQKLVSLIKEYSLYLRNNAKYARALKDYNVSDTSLLPFKRNDIITITFKDQENKWFMGQLNGKEGSFPVDHVEILLSDVPPPQPVHPVATLSPPMSPTIPNITNTPPPPPSISDSMSPPPQVGMLPPPPPPSVMGSTKPIEIPSLGIPPPPPSSSNSSVPNSPIGSPMMGIPPPPPTISVHSLSNSGNSTPPPPLPSLSTPPTLSTPPPISSPPNFRSSLRVSMLNTSNDGGDNSSDDPSKRLTVSPAIGTDSQLAQWASTRFRSFKRASTLNQQQATLKRKAPVDPNTAFYFNKDPIKESLIEMEAKLSKKAIKNFSEIMMWMGDYPIPKGQTASLVIQSIISRGIENHELRDEIYCQAYRQTNKNPKVESAKKGFELIYFLSITFSPSDSLLQPFMEQLMSRNIAIQSSSPQLASLIAVCIEKLESHPIPSYQQRKMGPSATEIQSFRSNLENGDISTCKIRFIDQSTKLAKINTYTTIREITDTVCRQYGISQQSIKMFGISAVNETAGISKVVSETDMIYDVLARWEQSEEKGEFYFQVRRRFFLDDVNKILDQEHLWTDDDICFELTYCQIRDEWMKGLYTNVNEKDSSIIAAILIQLLYPNQSKLVLTKEVVRQVLPDQILNSQNIKVWISMIESQIFELVSQTPEYLKLMFINLIGSKSPLFGCTLFNIQQKENPPKAWLAINKKGVSIFDPHTKESKNFWTFQSISNVAFTDDTFCIMTGNLMKPIKQTFTTDEHSSIASVYQFYSSQ
The following text describes a protein:
Function:
The terminase small subunit specifically recognizes the non-adjacent pacL and pacR packaging subsites and regulates the ATPase activity of the terminase large subunit. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging 'pac' sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging). Once the capsid is packaged with the DNA, the terminase complex is substituted by neck proteins.
Domain:
The N-terminus contains a helix-turn-helix (HTH) doamin that is involved in viral DNA binding.
Sequence:
MKEPKLSPKQERFIEEYFINDMNATKAAIAAGYSKNSASAIGAENLQKPAIRARIDARLKEINEKKILQANEVLEHLTRIALGQEKEQVLMGIGKGAETKTHVEVSAKDRIKALELLGKAHAVFTDKQKVETNQVIIVDDSGDAE
The following text describes a protein:
Function:
Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3, thus acting as a positive regulator of gene expression. Demethylates tri-methylated (H3K27me3) and di-methylated (H3K27me2) H3K27me. Inactive on H3K27me1, H3K4me3, H3K9me2 and H3K36me3. Acts as a repressor of the photoperiodic flowering pathway and of FT. May also be active on H3K4me. Binds around the transcription start site of the FT locus. Required for epigenetic reprogramming by resetting the expression of the floral repressor FLC locus, thus aluviating cold-mediated FLC epigenetically silencing occurring during vernalization and preventing inapropriate epigenetic states inheritence; Together with REF6, required for H3K27me3 resetting (especially in constitutive heterochromatin within the pericentromeric regions) and transgenerational inheritance of histone marks, thus acting in safeguarding genome and epigenome integrity during sexual reproduction.
Subcellular Localization:
Nucleus.
Sequence:
MGNVEIPNWLKALPLAPVFRPTDTEFADPIAYISKIEKEASAFGICKIIPPLPKPSKKYVFYNLNKSLLKCPELVSDVDISKVCKEDRAVFTTRQQELGQTVKKNKGEKGKSNSQRSGVKQVWQSGGVYTLDQFEAKSKAFYKTQLGTVKELAPVVIEALFWKAALEKPIYIEYANDVPGSAFGEPEDHFRHFRQRKRRGRGFYQRKTENNDPSGKNGEKSSPEVEKAPLASTSLSSQDSSKQKNMDIVDEMEGTAGWKLSNSSWNLQMIARSPGSVTRFMPDDIPGVTSPMVYIGMLFSWFAWHVEDHELHSMNYLHTGSPKTWYAVPCDYALDFEEVIRKNSYGRNIDQLAALTQLGEKTTLVSPEMIVASGIPCCRLVQNPGEFVVTFPRSYHVGFSHGFNCGEAANFGTPQWLNVAKEAAVRRAAMNYLPMLSHQQLLYLLTMSFVSRVPRSLLPGGRSSRLRDRQREEREFLVKRAFVEDILNENKNLSVLLREPGSRLVMWDPDLLPRHSALALAAAGVAGASAVSPPAVAKKELEEGHSELQNKEKTSLLEELSLFMEKLNDVYYDDDDGLLNDFQVDTGTLPCVACGVLGFPFMSVVQPSEKALKDLSERQGETDAQEIMTLSSEKSDCEWKTSSRYIRPRIFCLEHTIELQRLLQSRGGLKFLVICHKDFQKFKAHAAIVAEEVKVPFSYDDVLLESASQEELSLIDLAIEDEEKYEHSVDWTSELGINLRYCVKVRKNSPTKKIQHALSLGGLFSDTSQMLDFTTIRWLQRKSRSKAKPSSTSSFTPCEHLEVKADGKLRDNLDSQTGKKEEKIIQYSRKKKLNPKPSAEQVQELATLAKSKDFDKTCKNFSSRSHLDSAIRSEMNSEIGDSGRVIGVSFSINPCSSSFTVGHGQEHPEITVKFGSDLDGNVTNSLSMVNGDSADLTLTSISREQHQGHSMTSNNNGSNSGSHVVASQTILVSTGDNHDGPRKLSGDYVCSDVSVRGIQEAVEMSDQEFGEPRSTVTNIEDEQQSQIVKPTQREAVFGDHEQVEGAEAVSTRENLCSEIILHTEHSSAHVGMEIPDINTASENLVVDMTHDGEPLESSDILSSSNGDEASSNGLQVLNDELSMESEVSSSENTEVIEAPNSMGEAKKKRKIESESETNDNPESSIGFIRSPCEGLRSRGKRKATCETSLKHTETSDEEKKPIAKRLKKTPKACSGSRQQEVPTTTHPNRCYLEGCKMTFESKAKLQTHKRNRCTHEGCGKKFRAHKYLVLHQRVHKDERPFECSWKGCSMTFKWQWARTEHLRLHTGERPYICKVDGCGLSFRFVSDYSRHRRKTMHYVT
The following text describes a protein:
Function:
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step.
Sequence:
MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTLVCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQTASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELESLISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFGDDSQIDIRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLVTGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLESSLQHLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQTSAVTEQISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL
The following text describes a protein:
Function:
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
Subcellular Localization:
Nucleus.
Sequence:
MQEPSRKGRPPLAMLAATCDRVAEGSPESFPDPPKAKGFHPFKRTTPTMSGLTAEHAASRFAHMAAPGSMLGASLPYPLAPSSSLTSPFSGELFFSRKTEPRIPIATETAKSNTSPYGHKTGFSSETEHLAGILPPHLCGHSAYESWLKAATSASMLSRENGVHGFSPAFWSLPGAQASLLDLHSSAGTLPSHFGKMPTCSSASDCSALALSHSVLPYPPLTTTNPHLFSPSQLFPPSSYNSFLPPGYDIMSLTEMRSSFFGPAGLGLSLSRAGRRYSGRATCDCPNCQENERLAAAGQPLRKKNVHSCHIPGCGKIYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFSCPTCNKRFMRSDHLSKHVKTHQNNNNNSGNDNGGNADSKAAGETGKMSPIKKLASVGSSEAESSPSGTEGSPSPVSTGPGPISMSVPQSAALKVASP
The following text describes a protein:
Function:
Calcium-independent kinase involved in light-dependent phosphoenolpyruvate carboxylase phosphorylation.
Sequence:
MTGEFELANSYQICDEIGRGRFGTITRCFSPATKEFYACKTIDKRVLVDALDRECITTEPRIMAMLPPHPNIVMIHDLFETEDTLAIVMELVDPPTTIYDRLISAVGGRLSESESASYARKLLRAVAHCHRRGVVHRDVKPDNVLIDLGSGGVKLCDFGSAVWLGGEKTETAEGVVGTPYYLAPEVVMGRRYGEKVDVWSVGVVIYTMLAGEPPFNGETAEEIFETILRGNLRFPRKVFGSVSAEAKDLLRRMICRDVSRRFSAEDALRHAWIVNVGNLQSN
The following text describes a protein:
Function:
Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.
Subcellular Localization:
Dynein axonemal particle.
Sequence:
MSAALEKPQIIAHIQKSLNYTVFESKWIPCSAKFVCMGNFARGTGVMQIYEIQHGELQLVREIEKSKPIKCGTFGATSLQQRHLATGDFDGNLNVWNLEVPDSPVYSVKAHKEIINAIDGVGGLGIGDGAPEIVTGSRDGTVKVWDSRQKDTPVVNMEPTEGETKRDCWTVAFGHAFNDQDRCVCAGYDNGDIKLFDLRNMSLRWEKNIRNGVCSVEFDRKDINMNKLVATSLEGKFHVFDMRTQHPSKGFASVSEKAHKSTIWQVRHLPQNRDVFMTAGGAGNLHLWKYEYPAQRSKKGADDVEMGVAGSVNLLQNVTLSTQPISSLDWSPDKQGLCVCSSFDQSVRVLIVTKLNTV
The following text describes a protein:
Function:
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MEQTKALNALEPFIVLSKSATSPRAAADLVTRVTSAPNTFIFTELLQTPQIQSLEYSHEFSSYLTLLQIFSHGTYADYIANASALPALNDDQKLKLRQLSLLTLVANDGSNVPLDYDAMQRENNQAQPPNQSYASLTRRLELSSARELEELVISAIYAGLIEGQLDPANEMVQINSVAALRDVPARGVNGLLSSLQGWAGRCQATLQELEATMANLRDEADRRATEEQEWNNKMSQLLEDEQKGAVPSSSSSSLPFSWFNNTRGGGGGGDGAGAGGSFRGSGYSRGGGLSQGYRSSQRGSHQQHQNQSRQQQNHHHHHQSNQSGTNSLLTSGGGSYLSFREGPSAVSPSAAAGLMGSSTSFAALGGMETGSGSGSGPLGKRGSSDMDDSEEDIDDDTMDLDDEGDETKRGSKRKLTA
The following text describes a protein:
Function:
Essential gene. Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MEEDDEFGDLYSDVLQPFQPPVVLPPPPPLPHRSIDLNLRSQDQDVSEPNSAPISRVSDNDAVKLSTQDATRQAIVDGGGDDKDMSFDIEEPDADSTPTIPGLFVTGALPGLATDRGVSQVTTRIEQQVGGGGDGGYGGQGEGDDWDSDSEDDLQIVLNDSSRNVMIGGADRRSRMGDNEDDDDEDDEDPLVIVADTDPNQPMEEQMWGEDGLQGIEGDGKDGGEAGKGSGPGGATGPPKAGYSSHGYHPFHSQFKYVRPGAAPIPGGAASVGGPSSGQVRPPANLGPMAGRGRGDWRPLGMRNASAAQKGFHQPWGSNTAGRGLDFTLPSHKTIFEVDIDSFEEKPWRYPGVEMTDYFNFGLNEESWKDYCKQLDQHRIQTTMQSRIRVYESGRTDQGYDPDLPPELAAATGAQGVPVDSSNLVKPDSVQGDSAKVPANVRPTLPPGRPIPVETGSGERLPSIDTRAPRMRDLDAIIEIVCQDSHEDEPSGENGTDQADSSLPGENVPVETSYVNNKRPDTESAEHSPAQDEPHKNLLKKQDDEISRSTDSGQSFRSSSPVGDRGTRSSSVDREDVGGEAGKDAEMGEELKMSFTSPQSAVQEDDGGESKTERSSESSKARSGSHRDFQQEEDVIQDKHSSRPANNRKQYDNNAPHQSRKNQDRGKEMERTRAASKGGRENSNPHMELDSTYIYSIASREDFDKRKERDVDGAVWRRKEDDPYSRRGGDEGSRKRDREDDPGFRQRGKMRENEIRSKDDQVPSRKHMDDAGMRNIYEPDDHINKRRKDEEYLRRSRPEKNEISYGQRESMSRVKRERDDRLEHQKRDVQHKIRDDFDDHGSLRQRDDIYMQRDGNERLRERDVLDKLKLPHEDGISARGRERQVAVRGHRGSEDRSSRMKDEYKASDKEHVTKDTLRHAKQTKRRDYPGEESSSHHRGHEDFSARTDNIVNNEKKPRQERTGAKIDKFIDTLDGQRLQDRKHKDSRRKIKEQREGTESLSKQGEQNGSSVVTGSKGTNDARNCRSEIPHQPNTAKRHKENASSGDEIHDSKRGRTKLERWASHKEREDAVSAKSSSISSKLEEKENNTNGRLSEPVHGSIGKSRDVTEEKIGHDLADTKDGSEKGPGDRHLDTVEKLKKRSERFKLPMPTEKDTTGVKKMESETLPSAKIEGPVDSEGEYVWDERSCVRIGREYA
The following text describes a protein:
Function:
Ribosome biogenesis factor. May be required for both optimal rDNA transcription and pre-rRNA processing (By similarity).
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MATLYEEYTLCGVGPDKNSSSSGILGIELGKDVDHIIVTNSSRAVTVYKVSDQKPTGSWTVKQGQLITCPAVYNTKSQEYVVVTDNKVIRVWKEDDVNMEKAFKATVSSDVLRVIAASDSEPVVLFSCGAVMFLDSLLASPQQTIEGVLTEEEFIRWSTVVGAEHQLVLLFCTEKRGEHYLYAQRFNPNTVVKHRFETEPGPFAPISFSATCRGSNIHLQYLYMSGRIYESVLPLRSSVSEAEGVQALPRSLCLSLPLGEQELTSGAAIVLDEAHVAIVGFPHPSAGAGKDYLCIWNKHFQTLQACKELAGTIYSQIWCYSGKLYIPHGKILSVISFECQKSSLAAAMGKLKQTNQSESKSHTPLSSWTALPHNDSINAAKVKSRMSTRNASNVKSPLTVDQLIDHIKTAVVEDVQSAVGEFIHQTPQTDLQLAAGKVTMVLVSRSQTDDSFYPQRAFLQLLDTRYLCYSVCPELLSLAMAKRDFQLCQIAFQLFPDIPEAVTCAYLKTILSTPDSEMETLTLDTESLIIMKEMSPAQSQMEEGEQQNENGVSSSKQQRDFLSMDMKCPVGLHKGVLLNDVLQTAYSDKPLLQHLKDLTVLQVMVFLQYLHFLYLKYSQDVHKQIRALRIPSISQVIDWASLILDAHFTVLAVAPEAKSLVSDLHKFTRSQVKLYAELGKIEGSLQSLKKPKSTEHTGVYSIEVIELF
The following text describes a protein:
Function:
Probable transporter of a GTP-driven Fe(2+) uptake system.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MEKIKIRVALAGNPNVGKSTVFNQLTGLNQHTGNWPGKTVEKKVGYVEKDHYILEITDLPGIYSLTANTLEELISREFIVKEKPDIVILIVDASALERNLYLLLQLRELIPNIIIGLNMLDILKAKRYKLDVKKLEERLNIPIIPMIASRGIGIDELINKVIEVYEKDNLDPTKIDYGELEEDINKIESILPENLEDYPKRWIALKLLESDPIITDLCKKKLKREDWEKIKELIEKNESNPIRVATARYNFIKKILEGVLEKPEKQAISWTEKLDEYFTHPVWGSFLAILIVALIFYLTFTLNNFLAEPVKNVLDFMGDKLSSLLVFLPNWWRDLLIEGVWQGIATILSFTPLITFFFFFLALLEDSGYLARLAFVSDRLMHILGLHGKSLIPLVISFGCNVPGVMATRTLEDEKDRILLIILDSFIPCVPRILVASFFLSIFFPKQAFFLLILLYLISFISIFISGKILRTKVLKTSFNPLLMELPIYKIPNPKLVLLYIWDKIKHFLVRAGTVMAFLSAIIWILSHYPTGDIQNSILAEISRFFSLFMKPLGFNWELTTGLLSGFVAKEATLSTLSAIYGVSGSELGKILLENITPIAAFSFIVFQLLYIPCASTVATIYQETKSIKWTLFSMGYSLMYAYVFTFILHQILSIIGIL
The following text describes a protein:
Function:
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular Localization:
Mitochondrion.
Sequence:
MRNRATTPLSKPKIRQSWSKYNLYNLNRIRNPPTANRTFFQQKWTAKAMARAYHGEQVRESQWTRMFSRRLRSVVPMSPWKMAQDDGSSMAAGRGSGLETDMRSRAADVRTKTPYTNMTFAPLERRLDVAIFRALFASSARQARQFVLHGAVTVNGKKMRYPGYLLNPGDMFQVDPERVMYATGAPKDKFERREARVERKKAVETEKKEEGEGEEAKEGEEAEAKETEEEKLDTRETLKRLLSQAKNIMGSNKDVLPAKRKQELRGFQKAVRRVMSKSGASTSTLTDNLETQFAELLKLLKATKIQPKEEKESKKENADAAAKSEPAETEATANASNPVDTKPTEALTEAFRQATQNPEGEVDTSELTEEELDVLKRALVQMRDNPIDHSKPYATPWRPRDYMSAFAFIPRYLEVNQNICAAVYLRHPVARPGHSEVPTPFGEAVSTAAFSWYLRRR
The following text describes a protein:
Function:
May play an important role not only in the regulation of Adh expression but also in the transcription of other genes.
Subcellular Localization:
Nucleus.
Sequence:
MHTLTAAIEMDKLDANLEQQFDLNLIEAVKLNPVIYDRSHYNYKHFVRKAQTWKQIAETLGVPEQKCTKRWKSLRDKFAREMKLCQESRWRYFKQMQFLVDSIRQYRESLLGKCANGSQSANQVADPSQQQQAQQQTVVDIFAQPFNGSATTSAQALTHPHEITVTSDAQLATAVGKDQKPYFYEPPLKRERSEEEHSDNMLNTIKIFQNNVSQAVSAEDQSFGMVVTDMLNTLGVRQKAEAKVHIIKYLTDMQLLAQHNKY
The following text describes a protein:
Function:
Transcriptional activator of actinorhodin biosynthetic genes.
Sequence:
MRFNLLGRVHVITDAGCVIPLKSSKATQLLVLLLLRRHEVVGSGVLIEELWADHPPRSAMTTLQTYVYHTRRLLGEHRVTSDDRELVLTQPPGYFALIDEDELDVAVAERLIRTGGRLLEENRLEEALASLDAGLDLWRGPALSTVPCGRVLESNIAHLEELRLFGMQLRIDANWRLGRIGPMIPELRSLVISHPLNETLHAKLMGALCQMGRRAEALESYRNLRRILSDELGVDPTPEIQRMHMEILNGEKVLV
The following text describes a protein:
Function:
Required for pre-mRNA splicing.
Subcellular Localization:
Nucleus.
Sequence:
MSLETFGNEKSMNLDNVLLTNIQSSLYFKNLYPKRSYHEVIEEIKRNVEILAPYIPNTKTPSTTFCLLYKFFLMKLTVKQMKGLLGNNESPYIRAIGALYLRYCHPPANLWDWYVDYLDDQETVFISKNTEVTIQRFLLDLLKDNKFSGTVLPRIPTKIQQDLDKKIKDYEIENNLTYNNNNNNTKKDSYSRDNRDNRDNRDSRDSRDSRDSRDNYRYSRDSRDSRDSRDNHRDSYRDRDSYSRDRDRDNRDSYRDNYRDSYRNNSRYNNDDNGKDSYAEELERFKNERNKSSGSGGRNYSKRDDYDDYSKSRSNDRDRDRDYSSSSGGNGNGYKRDSYYSDDDDDSEDGRTYGGRKRSRSRSNSRDRDSKNNSTQKETTTTTTTATTTTEKQPKEESESLKKLRSLYGATSDQVSLD
The following text describes a protein:
Function:
Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex.
Subcellular Localization:
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with the chloroplast NAD(P)H dehydrogenase/photosystem I (NDH/PSI) supercomplex.
Sequence:
MAISKPPPLHFTFFHNQDSSIDTSDSNLALSIDTSRRRRDVLLTISGTLIPQLFFFDRKRSSSANAADFFNFGAPPPEPERTVELAQEGLRKNAENIKRIKEIMIEKKLWKEGGKELRRSASNMKQDFYLIIQAKPPKDRPLFRSLYSSLFNSITKMDYAARDGDETKVLEYYINIVAILDDIFPRI
The following text describes a protein:
Function:
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH, but not NADH, as an electron donor for its activity.
Sequence:
MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNGEAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALLAVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELVEELSMFAKAGNPGV
The following text describes a protein:
Function:
Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments. Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (By similarity). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Sequence:
MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQASAKFTSIRREDRATFAFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVDMRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMGQQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIGFLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGSTIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQASKAH
The following text describes a protein:
Function:
Histone demethylase required for G2/M phase cell cycle progression (By similarity). Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (By similarity). May play a role in the regulation of the circadian clock (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MHRSVPEQVSAELPATLEQFQITLGADVEDRVEECVREAARCLYRGAIVQCGALGELLIDYSWEKLNARNWREVGREWRAVYSYGCLFRAVGLCSVTGSIEEALQVCDIGLLMGAEIMDNLLGRIISVLQRIAPSREETKLEAERGVREPGLESSKLHSPGEHSNKKSFASVTGRKRIREGPEADFDPKGCSISEKVPCLLVPVLDSETAIPKLHCPSLEHFRDHYLVPQKPVVLEGVIDHWPCLKKWSVEYIQRVAGCRTVPVELGSRYTDAEWSQRLMTVNEFITKYILDKQNGIGYLAQHQLFEQIPELKEDICIPDYCCLGEASEDEITINAWFGPAGTVSPLHQDPQQNFLAQIVGRKYIRVYSVAETEKLYPFDSSILHNTSQVDVESPDQNKFPRFSQASYQECILSPGQVLFIPVKWWHYIRALDLSFSVSFWWS
The following text describes a protein:
Function:
Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
Subcellular Localization:
Mitochondrion matrix.
Sequence:
MLRLPRITRRALSSGALAPHFDRPLPPPPPAPPAPLCALPPLTAPDALAPLTRRTVRHADALVARIAAAPAHPDPAELRRVVKNLDRLSDVLCGVIDMCELVRNVHPDPRWVAAAEKTYETLCSFMNQLNTSTGLYDALVATVSHTFPGNPLSPAELRVAQTFLSDFERSGIQLPPGVRAKFVRHSDNILSLGRTFLSFAAAGPSADTPIEIPEPEVLLAGLSSKFVASLPRKKRKGPALLAPGSWEAQMIGRYADNEEARRLVYIGSMREDKDRVYVLETMLKERAELAHVLGKETWADVALSDKMAKTPQNVLQFLTSLATHHRPSAAADVAALQRLKALSTVSRTSSQLPTVHAWDRDHYAEQYAASLLPNGSLPSITPYFSVGTAMSGLSHMLSRLYGISFKPVSVAHGEVWHPSVRRLDVMDEHGKRIGVIYCDLFSRPGKPSAGAAHYTVRCSRRVDDDPSEGDGLPPGWDQHLGKGMEVQGEALHGKEGKYQLPIVVLTTDFGTVEESGPALLGWNDLETLFHEMGHAIHSMIGQTEFHNVSGTRCATDFVELPSILMEHFISSPAVLSTFATHYTTNEPLPIPLIQAHLQLDQSLKALETHSQILMALLDQKYHSIKHGEQLDSTRVWNELQSQVGVIPPVRGTAWQTQFGHLYGYGATYYSYLFDRAIAGKIWSSLFARGRTGPAAANHDPAAAEDILSREGGEAFKEKVLKWGGGRDPWEMVGDVIGGAEGEQVAKGDEKAMELVGRWMIK
The following text describes a protein:
Function:
Capsid protein self-assembles to form rod-shaped virions about 21,6 nm in diameter for the narrow nes and 22,4 for the wide ones, and 110-150 nm in length depending on the size of the encapsidated RNA. They display a helical symmetry of 23.2 subunits per turn of the viral helix and with a central canal enclosing the viral genomic RNA.
Miscellaneous:
MISCELLANEOUS: The genome of this virus consists of three linear, positive, single-stranded RNAs encapsidated in separate virions designated RNA-alpha, RNA-beta and RNA-gamma. Three proteins (alpha-A, beta-A and gamma-A) are translated directly from these genomic RNAs and the remaining proteins encoded on RNA-beta (beta-B, beta-C and beta-D) and RNA-gamma (gamma-B) are expressed via three subgenomic messenger RNAs.
Subcellular Localization:
Virion.
Sequence:
MPNVSLTAKGGGHYIEDQWDTQVVEAGVFDDWWVHVEAWNKFLDNLRGINFSVASSRSQVAEYLAALDRDLPADVDRRFAGARGQIGSPNYLPAPKFFRLDKRTIAELTRLSRLTDQPHNNRDIELNRAKRATTNPSPPAQAPSENLTLRDVQPLKDSALHYQYVLIDLQSARLPVYTRKTFERELALEWIIPDAEEA