lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Transcription factor involved in monocyte-to-macrophage differentiation. Forms a complex with NPM1 to translocate to the nucleus, acting as a transcription factor that promotes the expression of the genes involved in macrophage differentiation, such as STAT3, STAT1 and JUNB.
Subcellular Localization:
Nucleus.
Sequence:
MEALQRQQAARLAQGVGPLAPPHPPPPPRPSFPGSHTLEAPEKGLGEVGAEEEEDGQDEEEEEAGAEDEAAKESRPGTRGSSSPSSQPPGPHPHEWTYEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSAAFTLRTQYMKYLYPYECETRALSSPGELQAAIDSNRREGRRQAYTAAPLFGLAGQPPRGTPGPAPEPGPAPPTPGPRSAQGPASGLPAHACAQLSPSPIKKEERLDGPLSLAGTGISSINMALEINGVVYTGMGPVGCFSHEVRGIY
The following text describes a protein:
Function:
Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates inhibition of NK cell cytolytic activity.
Subcellular Localization:
Cell membrane; Single-pass type II membrane protein.
Domain:
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases leading to down-regulation of cell activation.
Sequence:
MLHSKRREYTANNQDVTYTELKTCKSPWKHRIPTVKQSPVVLCEEQLKYGELTFHRTPQPQPRKQAMGRKRQGPKSTVWRVVTGMLGALCVVLMTTTGILLPKLFSSQEEQCRKTSLHPLRCPKDDASCDLCSSDWIAFGNNFYCVFKENTKTWAESQSACEELNSHLVIIDSKAEVENLLLFEMDGWILHKMDGTNSSWLWRNDIKIQNTLTNDSEKKNHSCHYLRGNLFMPDECSAKKSYICEFNI
The following text describes a protein:
Function:
Involved in natural transformation. Probably part of the ABC transporter complex YdcSTUV. Probably responsible for the translocation of the substrate across the membrane. During natural transformation, may serve as the channel for dsDNA uptake (Probable).
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MHSERAPFFLKLAAWGGVVFLHFPILIIAAYAFNTEDAAFSFPPQGLTLRWFSVAAQRSDILDAVTLSLKVAALATLIALVLGTLAAAALWRRDFFGKNAISLLLLLPIALPGIVTGLALLTAFKTINLEPGFFTIVVGHATFCVVVVFNNVIARFRRTSWSLVEASMDLGANGWQTFRYVVLPNLSSALLAGGMLAFALSFDEIIVTTFTAGHERTLPLWLLNQLGRPRDVPVTNVVALLVMLVTTLPILGAWWLTREGDNGQ
The following text describes a protein:
Function:
Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus.
Domain:
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Sequence:
MGLEFKYVEDSSDEDEKMTASEEKWQDLEALQARHEELVNSMYREELLNYRFSELQELQDAENPNFVEEIITGHMEECASCIEELEKALKTDPVDYHFCSPVWSYGCQIGNSNASIGAHQVAIWCGKFRDCVSREDKQGCLDALEKVKEAFDILRPKLLTMLEFEREIAATGGTVYYMNCNNHV
The following text describes a protein:
Function:
Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
Sequence:
MTKHTLEQLAADLRRAAEQGEAIAPLRDLIGIDNAEAAYAIQHINVQHDVAQGRRVVGRKVGLTHPKVQQQLGVDQPDFGTLFADMCYGDNEIIPFSRVLQPRIEAEIALVLNRDLPATDITFDELYNAIEWVLPALEVVGSRIRDWSIQFVDTVADNASCGVYVIGGPAQRPAGLDLKNCAMKMTRNNEEVSSGRGSECLGHPLNAAVWLARKMASLGEPLRTGDIILTGALGPMVAVNAGDRFEAHIEGIGSVAATFSSAAPKGSLS
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion.
Sequence:
MAALRMGKLTTMPTGLIYASISVHVAKEEESKKQLVKPEQLPIYTAPPLQSKYVEEQPGHLQMGFASIRTTTSRYIGWCKGVYVFVKNGIMDTVQFGKDAYVYLKNPPRDFLPKIGVITVSGLAGFISARKGSRFKRIAYPLGLATLGATVCYPVQSVIIAKVAGKKAYATSQQMYEAVKSLWTKNNKKLPEHKEKTKLGSADETETPAETTHNLKHSVPLPAELSSETKTKSTSGATQFMPDPKLMDHGQSHPEDIDMYSTRS
The following text describes a protein:
Function:
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Subcellular Localization:
Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
Sequence:
VCLCALAEAYPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRYGKRSSPETLISDLLMREGTENVPRTRLEDPS
The following text describes a protein:
Function:
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system. The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA. The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB. The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone. The cyclization of the last ring could be mediated by the lactamase-like protein vrtG. The proposed post-PKS tailoring steps are a hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF. VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin. Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin.
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MFIAAVTHNWMERLAALSLLHYVLGAIFLLLLFHMLSNFFHPGLVDVPGPFAAKFTDLWRLFKVWQRRFKEDLPGLHASHRSTLIRIGPRMVSCSDPRAVELIYGFHTEFSKSDMVKAMAPIYKGKKQPTMFAAADNKTHARIRKPVAGAYAMTSIMQRMDELFIRPKRACDIHNWVQYFAFDMVLEMTMSRNLGFMKAGGDVDGVLKQLQKDLDYRGIALAMPIIDRIWRLNPVSKFFKPKQSGHFAMRCKRILEDRMAYEKSLDSRTQQQQDQKPHDFAHRFLEAQRKDPSISDGQLIGYMQANLIAGSDTTAVVMRTAIYYTLKQPWILQRLVTELDQYHGPLPVPFRIARFEMPFCGAIVREALRRHFAFIGMMERQTPPCGVVMPDGRRLPGGVVIGMHGDLIGRDRAIFGEDADEFNPLRWLARPGEPEAKYQERLRAMNAHDLAFGHGPRGCIGKHVAEMEIYKFIPTFFALIQPRFMRPEQSWTVRQLFVFKQSGMDMMLDWRQGKGLQSMA
The following text describes a protein:
Function:
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Subcellular Localization:
Cytoplasm. Note=May associate with membranes.
Sequence:
MAQQQIHDTKNKLEKAVLVGVHAQDDKQFNFESTMEELSSLSETCQLEVLGQITQNRDRVDRKYYVGKGKIEEIQAFIEFKDIDVVITNDELTTAQSKSLNEALGVKIIDRTQLILEIFALRARSKEGKLQVELAQLDYLLPRLQGHGKSLSRLGGGIGTRGPGETKLEMDRRHIRTRMNEIKHQLRTVEEHRERYRNKRNQNQVFQVALVGYTNAGKSSWFNVLANEETYEKDQLFATLDPKTRQIQINDGFNLIISDTVGFIQKLPTTLIAAFKSTLEEAKGADLLVHVVDSSHPEYRTQYDTVNDLIKQLDMSHISQIVIFNKKDLCDHASNRPASDLPNVFVSSKNDGDKLLVKTLFIDEIKRQLTYYDETIATNNADRLYFLKQHTLVTELKYDEIENVYRIKGFKK
The following text describes a protein:
Function:
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Sequence:
MEPNGYMKEETKRMNGGGDVAEKLPERSYGADCRIYVPDHPTNRFKNLYDTVFDEFFLAHIFGWWGKAILIRNQPLLWVLSIGFELLEACVKRIQGDDSGHKHCTGQYFDYWHCIDKCVSICFALHIFFFYFMYTEMKTVILDLQVAPKLFAKLK
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (By similarity). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (By similarity).
Subcellular Localization:
Cytoplasm, cytosol. Peroxisome membrane. Note=Localizes to the peroxisome when interacting with the PEX6/APEM9 complex.
Sequence:
MSRNRQIIIPDDVMETEAVVNTVAGVDCFVSLPRQLLHALQSTSSSPLPPLLPVELRSGDRRWSVAWSGSSSSSSAIEIARVFAESISLPDGTVVKVRVLPNVPKATLVTVEPETEDDWEVLELNAELAEAAILSQVRILHETMKFPLWLHDRTVIRFSVVSTFPSKGVVQLVPGTEVAVAPKRRDRNLKAKKSQEKECNNVKALLRVQETDRSAFHEADVKGFELRVALTSIAYIHPETAKKHSLESLQLISVSPRIPLKGSAKKDEALNMKNSEASKVAENGTSSAKKEPRQAILRLVFSDLAAKGHLMMVESLRLYLGAGLHSWVYLRGCNVNEDKEIPALSLSPCVFKISENEKVLDKGTDRLGNNNSVRKSSHPPSGLSTYVDVVDWSVHDKVVTALSSEGLHDEGNHDKNKKGLEYLTRLWSLAQLDAMASVTGVDVSSLIVGRETFFHFEVRGLESYKSIDGQPSVNDRWESGKKDKHTPLEILYVMTVSDESLLGDKFAGYDLSLDRSEKSDNVVHIEPVLEKMNLGEPIYLKSAKETHCNKGVSPDISSLTWMGPIVSDVIKRMTVLLSPAAGMWFSKFKIPSPGHILIYGPPGSGKTILARAAAKYFEEQKDLLAHVILVSCSTLALEKVQHIHHVLSSVIAEGLEHAPSVIILDDLDSIISSSSDTEGTQASVGVTMLTKFLTDVIDDYGEYRNSSCGIGPLAFVASVQSLEQIPQTLSSSGRFDFHVQLAAPATSERGAILKHEIQKRLLDCSEDILLNLAAKCEGYDAYDLEILVDRAVHAAIGRHLPLESNISKYNLVKEDFTRAMHDFVPVAMRDITKSASEGGRLGWEDVGGVTDIKNAIKEMIELPSKFPKIFAKSPLRLRSNVLLYGPPGCGKTHIVGAAAAACSLRFISVKGPELLNKYIGASEQAVRDIFSKAAAAAPCILFFDEFDSIAPKRGHDNTGVTDRVVNQFLTELDGVEVLTGVFVFAATSRPDLLDPALLRPGRLDRLLLCDFPSPPERLEILTVLSRKLLMADDIDLEPIALMTEGFSGADLQALLSDAQLAAVHEYLNREDKPETGTTPIITDPLLKSIASKTKPSVSETEKQKLYDIYSQFLDSRKSSREAKGKRATLA
The following text describes a protein:
Function:
Bifunctional cytochrome P450/NADPH--P450 reductase; part of the gene cluster that mediates the biosynthesis of fumonisins B1 (FB1), B2 (FB2), B3 (FB3), and B4 (FB4), which are carcinogenic mycotoxins. Within the pathway, FUM6 is responsible for the oxidation of the C-14 and/or C-15 positions. The biosynthesis starts with the FUM1-catalyzed carbon chain assembly from one molecule of acetyl-CoA, eight molecules of malonyl-CoA, and two molecules of methionine (in S-adenosyl form). The C18 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of alanine by decarboxylation, on the carbonyl carbon of polyketide acyl chain. This step is catalyzed by the pyridoxal 5'-phosphate-dependent aminoacyl transferase FUM8. The resultant 3-keto intermediate is then stereospecifically reduced to a 3-hydroxyl product by reductase FUM13. Subsequent oxidations at C-10 by the cytochrome P450 monooxygenase FUM2, C-14 and C-15 by FUM6, FUM12 or FUM15, tricarballylic esterification of the hydroxyl groups on C-14 and C-15 by acyltransferase FUM14, and C-5 hydroxylation by 2-keto-glutarate-dependent dioxygenase FUM3 furnish the biosynthesis of fumonisins. The tricarballylic moieties are most likely derived from the citric acid cycle, and their addition to the carbon backbone may involve FUM7, FUM10, FUM11 and FUM14 (Probable).
Sequence:
MSATALFTRRSVSTSNPELRPIPGPKPLPLLGNLFDFDFDNLTKSLGELGKIHGPIYSITFGASTEIMVTSREIAQELCDETRFCKLPGGALDVMKAVVGDGLFTAETSNPKWAIAHRIITPLFGAMRIRGMFDDMKDICEQMCLRWARFGPDEPLNVCDNMTKLTLDTIALCTIDYRFNSFYRENGAAHPFAEAVVDVMTESFDQSNLPDFVNNYVRFRAMAKFKRQAAELRRQTEELIAARRQNPVDRDDLLNAMLSAKDPKTGEGLSPESIVDNLLTFLIAGHETTSSLLSFCFYYLLENPHVLRRVQQEVDTVVGSDTITVDHLSSMPYLEAVLRETLRLRDPGPGFYVKPLKDEVVAGKYAVNKDQPLFIVFDSVHRDQSTYGADADEFRPERMLKDGFDKLPPCAWKPFGNGVRACVGRPFAMQQAILAVAMVLHKFDLVKDESYTLKYHVTMTVRPVGFTMKVRLRQGQRATDLAMGLHRGHSQEASAAASPSRASLKRLSSDVNGDDTDHKSQIAVLYASNSGSCEALAYRLAAEATERGFGIRAVDVVNNAIDRIPVGSPVILITASYNGEPADDAQEFVPWLKSLESGRLNGVKFAVFGNGHRDWANTLFAVPRLIDSELARCGAERVSLMGVSDTCDSSDPFSDFERWIDEKLFPELETPHGPGGVKNGDRAVPRQELQVSLGQPPRITMRKGYVRAIVTEARSLSSPGVPEKRHLELLLPKDFNYKAGDHVYILPRNSPRDVVRALSYFGLGEDTLITIRNTARKLSLGLPLDTPITATDLLGAYVELGRTASLKNLWTLVDAAGHGSRAALLSLTEPERFRAEVQDRHVSILDLLERFPDIDLSLSCFLPMLAQIRPRAYSFSSAPDWKPGHATLTYTVVDFATPATQGINGSSKSKAVGDGTAVVQRQGLASSYLSSLGPGTSLYVSLHRASPYFCLQKSTSLPVIMVGAGTGLAPFRAFLQERRMAAEGAKQRFGPALLFFGCRGPRLDSLYSVELEAYETIGLVQVRRAYSRDPSAQDAQGCKYVTDRLGKCRDEVARLWMDGAQVLVCGGKKMANDVLEVLGPMLLEIDQKRGETTAKTVVEWRARLDKSRYVEEVYV
The following text describes a protein:
Function:
Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors.
Subcellular Localization:
Golgi apparatus. Secreted.
Sequence:
MAAGLLRVLLFLGFSARGPAPAGAAKMKVVEEPNTFGVNNPFLPQASRLQAKRDPSPVSGPAHLFRLSGKCFSLVESTYKYEFCPFHNVTQHEQTFRWNAYSGVLGIWHEWEIANNTFTGMWMRDGDACRSRSRQSKVELACGKSNRLAHVSEPSTCVYALTFETPLVCHPHALLVYPTLPEALQRRWDQVEQDLADELITAQGHEKLLRTLFEDAGYFKAPEENEPTQLEGGPDSLGLETLENCRKAHKELSKEIKRLKGLLTQHGIPYVRPTETSSLEHLGHKTPRAKPPEQLRGDPGLRGSL
The following text describes a protein:
Function:
Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin. Strongly reactive with Glu, Gln, Trp, Asp, Ala, Leu, Phe, Gly, Tyr, Met, Ile and Val. Little or no product formation with His, Ser, Thr, Arg, Lys, or Cys. Also active on pyruvic and butyric acid analogs of IAA, PAA and the synthetic auxin naphthaleneacetic acid (NAA). The two chlorinated synthetic auxin herbicides 2,4-D and 3,6-dichloro-o-anisic acid (dicamba) cannot be used as substrates.
Sequence:
MAVDSLLQSGMASPTTSETEVKALKFIEEITRNPDSVQEKVLGEILSRNSNTEYLKRFDLNGAVDRKSFKSKVPVVIYEDLKTDIQRISNGDRSPILSSHPITEFLTSSGTSAGERKLMPTIEEDINRRQLLGNLLMPVMNLYVPGLDKGKGLYFLFVKSESTTSGGLPARPALTSYYKSDYFRTSDSDSVYTSPKEAILCCDSSQSMYTQMLCGLLMRHEVNRLGAVFPSGLLRAISFLQNNWKELSQDISTGTLSSKIFDHAIKTRMSNILNKPDQELAEFLIGVCSQENWEGIITKIWPNTKYLDVIVTGAMAEYIPMLEYYSGGLPMASMIYASSESYFGINLNPMCKPSEVSYTIFPNMAYFEFLPHNHDGDGGVEATSLVELADVEVGKEYELVITTYAGLYRYRVGDILRVTGFHNSAPQFKFIRRENVLLSIESDKTDEADLQKAVENASRLLAEQGTRVIEYTSYADTKTIPGHYVIYWELLSRDQSNALPSDEVMAKCCLEMEESLNAVYRQSRVSDKSIGPLEIRVVQNGTFEELMDFSISRGSSINQYKVPRCVSLTPIMKLLDSRVVSAHFSPSLPHWSPERRH
The following text describes a protein:
Function:
Component of the post-replicative DNA mismatch repair system (MMR).
Sequence:
MRKNGKEDDDDELFEISKKQQRKKSTNRKRSSRRLKKADDEDDDDYTPQAQKESSSSELQPSSEDEKQNKKRQSHTNVKSKGTRQKKQPKKTEQQPQQQQQESCQEEQQHNKGDEEFYKLAEQTLPIFMQPEHIRDSEGRRPDEPDYNPSTIDIPNDQYQKLPPMFRQYWNAKKNHLDSMIFFRCGRWIAVMYNDAIIVAKMFNRYLGFWGKDRPCVTVYDNQLPIYQRALLEKGHKIIMIEQLEKADVANKEDGEVVRREITQMISRGTLQDLGDAETYEQRNLLVLVCSKAPVNLKGHTYIYGVSIVDCTTNLFTFDQFFDDAQSNHLRSIIYNTKPVEVILCKTPPEIEKIFKNICNPTIIIYKKSFKDCEFIFQQFKIEYMEVVKGKNDQNQKLFDGIVIPSRKEQSEQKIDIDINQGLYSDSKQEIREEKCVENYQLSQDYPNILIELEKQFYHEKKQQDKEDDESSFYSYYYSTQSLYLLLCYLRQLLISDSVYRRGKFNFLDSNFTHNTHLYLDSQALESLEIFNVNLQTKITTAGSLFDYLNRCATAPAKRLLTKWVQSPLQNYKLIIERQECVQELTNLIPKCAEFQRRIKSLPDIERAIIKCFNTIHSHKLKAVPITGGESIGKTKLKEIKNVLSHIRQAAEAFKIFDQDIKQLKSKKLKEILNYRQNAKILKDSLDELEKCMTMDDNEPKPVKGVSPEYDQTLDRLNEITDSLQDELEKWKKKLKCPEIVYTHARMKYQLEIPEKYLEGNQKPKELIITSKRQGFQRFQTTFIEEQLYKLRKVEDELSQKLLPFINEYFTKFYSHRKEFFQLISYLSEADCLISLALVSNEQKVSCFPQIIQDESAKRCELIEAYHPCLLQNKDVEWVPNTIKFTGSIDTLLLTGPNMSGKSTLLRLIGVSIILAQIGCAVPAQSFTLTPFDRIFCRLGATDRLLEGKSTFFIELEETKTILDNCTSRSLVIIDELGRGTSTYDGVALASAVLRFLSDKTKPMTLFATHYHILLDEFALFKNISQCVMKHYQEKDQVVFKYKLIEGVAEKSFATNVAQIAGVPKEVIKKAKQMEAKITKEESKINKNREILKKFNQIIKQLL
The following text describes a protein:
Function:
Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSESCANPLLLEWIKEWLDQARERNSKGVTVYKKAYESMKACPLVFQHPSEAQQLNGLGPKLCERLTEKLKAYCEENGLPMPEHPQKAAASKRTSDEGVDDPPAKKPRKAKPYVPSLRSGPYALLLGLATLDENASQGLTKAQLIEKAQPYCDSSFTAPPDPSKFYTAWNSMKTLLQKELVYEHGRPLRRYALTEEGWEVAKRIKKTLPGGDLNTLAFRHQTGILSIEQGDSSTHVRSNTSTSAAPGPRDNDNNIVAQESLNGNNDEPIQIQDNDRGRDPIDEIGIEPIILPANSFTIQLVLDTREVRSSKDRDYIANELSKKGITPEVRALELGDAMWVARCNDPTFLSQYGEECNEVMLDWIVERKRMDDLLGSIKDGRFHEQKFRLRRSGIKNVIYLIEEFAITHDVGSASAMKYQEMMASAIASTQVVNGYFVKQTRNLDDTIRYLARMTYLLQKMYCFSPPTHTLSLIPSRQLSSAQSYLTTLERLRARDPSVTYSVTFSTFSALTSKSDILSLRDVFLKMLMCTRGVTGEKALAIQKRWSTPREFVEAFERLDEKGREDMVFERTKTLVGRKKMGKVLSKKIADIWGTGG
The following text describes a protein:
Function:
Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specification of asymmetric gene expression patterns in gustatory neurons. May also regulate genes involved in other biological processes including transport, small molecule metabolism, and growth. Inhibits dauer formation, by antagonizing daf-12; [Isoform a]: Specifically required for maintaining the timing of larval development and molting cycle rhythms.
Miscellaneous:
MISCELLANEOUS: [Isoform a]: Produced by alternative promoter usage; MISCELLANEOUS: [Isoform c]: Produced by alternative splicing.
Subcellular Localization:
Nucleus. Cytoplasm. Note=Expression is generally more enriched in the nuclei than the cytoplasm. Cytoplasmic expression is enhanced in lateral seam cells during the molt periods of larval development.
Sequence:
MEPAGHSSATHNIVVPNANPTQPQPLAPAMREEGATLSPPNTWSSSSVEFLDDADDNRLLFTCTFTLPHGTVLSSATYADGFHEQYLTIGDNFLARLEPKGQSFILSAAAASVKQRIFARVTMPDGALRACELLCEFETDRAKITVLALRSAFSLQASHVSSNFHVFTFITKHSSTCALTHIDYASIPYLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNSRGKIVKSIADLRLVAHNGSILRCQTEWSAYVNPWTRKMELVVARHRICSLPIGDSDVISSPPPGIQSNTLPPVMAKTFEDELRTIMNKPVPSTSRHSHHHHHSSLKDQNQGFPANIDLGAYIDKIVEQLVVNSTAQQQQKVAVAAAAAAQAAQAAVVATAQIRKVASAPPTTSTDPPLSYTQINCLENVHRLLKSQSRPESPAKQDEPFDEKKYPPQTPLTREALTLHTKRFEDEYKDTWCRRLKRLSDDVPSSPPAKRTTPIHWTSSSQNHYRTMAPAPPPPPGKNYQITYTPLDDLTDQKSTNTKSDVENVAYPISGSKFSTPMRLSIDGLLPRGATSTGGASPTSGTNSPPVFPKTSSSSSLLMLRDSQN
The following text describes a protein:
Function:
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.
Subcellular Localization:
Cytoplasm, cytosol. Nucleus, nucleoplasm.
Sequence:
MITPAFELSQDPDFLTITISVPYARVSEFDVYFEGSDFKFYAKPYFLRLTLPGRIVENGREAASYDADKGVFTVRMPKETPAQHFEGLNMLTALLAPKKSRSAKPLVEEIGTPELSEQEQEEELDWEIEQIPYEAATKNTLNTQCQYGFGNLRWGVFQRLQDELNDVVDVKNPDLTPVTERRQKRLAAEEAKFDPDHYLADFFEDEAIQGLLKYKAWWTNLYAKRMASVEESQEPGNQTELVSFSEEEKYQLRNFTNKSYLLDKGAHHQVYLSLVDILLAYSYEMCVTEGEKNVESSWNIRKLSSTLSWLESWTSVHDVLIAFGRRVLCYPLYRHFKLVTKAQRDTIQILQLGKSAILKCLLDIHKIFRENDPAYILNDLYISDYCIWIQKAKQKKLAALAESLQKVQIAKAHLKFELEELETAALLVQEEETALKAASSRSSRTSLSETEESDSDESEASDFEEVNDLSSELFKERMVQDSDNLTLDGVQEKAFTSQSRNVPCALIEELKNQIQTGIKLSEPPECLTGNNSATENDLIKKEFVLTC
The following text describes a protein:
Function:
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence:
MVMASKSNSLTFGAACFTTCPFSRTKTCCIHFLAIPNAKSRATFSLGPTLSKRMSLGILSSPIETTPTHLITPISALNSGLEASITDSNDISAILANAKIVVDSEDENKIQLRVDLTGDQTQKVFDRILTNLGRTAPPVPGFRMQKGGKSSKIPKDFLVQMLGEERVTKFSIQEILNSTMADYVKKASDFYPFICGCHGYKLISTFDDTIPGKLGCKGPEDKHYPNARTTQKIIQARK
The following text describes a protein:
Function:
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Sequence:
MSRTGGKRPLEFPKSSRVVRSSEFTKALRRGGVAANDCLVVFALPHDVPDADGEPSPDESKTVKCRLGVTIPKKTGNAVVRNRWKRLIREAFRLNQTQLPSGFDYVVRPKKDVTADWKMIEKGFVKLVGRAVRRSQSSADRSSTRS
The following text describes a protein:
Function:
Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.
Subcellular Localization:
Golgi apparatus.
Sequence:
MDLSSGGPSSSSDVASELDNSDAMQLVRQAVLFENVELLADLFKVNPWVWNRVDRHGRTPLMLAAHNGKLDSLRTILMLSPNSLNLVNDRGKTALHMAAESGETSIVLELVELGSDPMKSDNEGHCALELAQMAGHNEVAAKLIDAIQKESEDLNEAHTMIISACISGSADVVYEISRRFMEKKQSREILFNGRNEEDETALLIACTNGHIEIVRHLLQFEEHLLQSHVSKDTVIHAAVSSQNVEVLQLCLEKFPQLVKSTNNEGSTCLHWAARCGSSECVSTILNFPFPSEFIIEIDTVGAPAYQLALDVNEVDGECRTAMYLAVAEGHLEVVKAMTDFKCTSIDGRQRCPFQLDVYCTRGRTPFMLAAFNQNLPLMTLLLDAGADVNLPLAVLDTEYSVEEGRCIGSGALVEAVRSDGLHIVHFLLDRGALDTDNKALRLAAQGKNEKLIRVFLVRLVFADPEYKINKKNIDVGQIQVGQSLLPSSLCPSKAAQLNWNSANLEQLQSDWFVAAALHVNPRLRTTRLSLAAITRVDLSDNRLNTFPSILFQMPSLRSLNLADNSIRKIEIPTYYISSTSLEILNLRNNQLECIAIQFLSSLPQLQQLDVSKNELSQLPEYIWLCPALKELNASYNRLSTLPMVARASRGERPRLNNSNNNFNTQSPTQESNPIVVDDPPNVTSNPLRRQNVWQASINLSKVDDDSLFPDFPVTSSNTLTTINLSFNKFHTFPFCLACTCPRLLILNMSNNSMTSLPPMACVPAHLRTLDLSYNKIQESFIEASPLHVVCHAVPPTTSNGSMLPKRRNSPARQHRSRSKSAVRSQRSLSVSRHHALIDPQKEEESCVHKRHDSLEWLKTLQLAGNRLRSISVTNAASKVLLPALNVMDISDNKLLQAPPDVARLTLLSMLNLSGNTAIKELPPDYGMLSRLWSLSLKGCSLKEPLESMVNVENCKTVEIVAYLKTILEESKTYHHLRLMILGSDGVGKSVIWDALCKEAVQKRQPIHSETGVIRQAEWKFEAKRSKGDKNLGPVGFSVIDFGGQREYHSTHQYFLSKRSLNLVLWKITDGDEALAQLDTWLVNIHARAPNSTVILVGTNLDQVASNSSKFGPGYIDIMEQKVRTRYMVADADKSGLPRIVDVILINSTSRNDVKALLNTIYRTAWEVRMGKERAMEQQIPSSYIALMKVTKELGVEFRKEGQPAVMTVEAYRERVKKRMISKFGRPFRDDIEFYAACTFLHDCGELVRFEDATLRDLIFVDPLWLAEFLTSVVILRSPNLPAGLLSTDAINPHTRSFKSGALLMLKTQLLDLLHKFELALATQPRQLLIPSLLPDEYRLRSDFLASAVKIRMKMSQWNVRCPSPAGSPTKSPLRRTSPTDQNGVGSEDVMLQFTYDDDQLLRRIYALAYIPSGFWSRLVTRIVGDKNVCAAIESIFMTTSADRAKIADIATKHAKAEWVVWQTGIELHVKGHSLFTLKQFLPLAEVRDIDYSAIDMRAKDEQKRWRTWNQPSHRPIVEMVVNSLSISAASQHGRKLSMKTDVEGRSRLLAMISDLLDTLLEDWYPALGTRFVHSSEGDLLVSRYVLCPQCVRDAERNGSRSRTSSSASHRRSQDDGELPITSSSHMKGSRTTGDISKCRGGVVHCFVIEECMLAGREYNWVECPSHGGLHMRELAPDTVFADIENALTIHPDQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFCAAPEFTHLLDVCELGEALPPTQLMAVGITDEIDDPDDFEAQLWLSGREMVVMGCTQYGFVDQKSIELPHRGKYVSKVRDSVWSCDECGQVTVYGISLHETGHLQLPSLNGTLICAPELISNDVLILISDKQIVLLKLSESNSVSHLGTIDSPYEIRTATFLGNGSTRQIWAGHSEGRISIHHIASNDSFSFSSSLYLPDDKCIVRQLVGSKDAQKVWIALEKSSKVQMVEVEKRQVTGSLDIRKVMPGSETIHTIDMEMASQNYVTCIGLLERNDGDQLYIGTSKGLLVIAHATTLQPLSACRPFEGDITSICILEEPSREEENTRGKATTLSTASSESGLGWVRERVSETVDRFRSSPATVETQGAALVVCIGRQFRSLSHRFVAEEKLADVYSIAVWRTEEWAL