lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein.
Sequence:
MAVSQIVLGILGNIIASVFFVSPVLTFWRIWRKKTVEDFSGLPYLGCFFNCAAWTFYGLPLVIEGGTLVVTINGAGAALFFTFVLIFLIFSRGKERLKVGTLFVAVIAFLVVLIVVTLTTVRQNQRKTVVGSTALAINIIMYSAPLSNTKLVIKTRSVEFLPFFFTLMSFINPVVWTAYAAVTSDLFIMIPNAIGIALGSFNLLLYGIFHKSKPKQKPKVEDKQVENINLKEQLKHSADSDGTTAPATETDAKKQIVDSSA
The following text describes a protein:
Function:
Catalyzes the tautomerization of the 4-oxalomesaconic acid keto (OMAketo) generated by GalA dioxygenase to 4-oxalomesaconic acid enol (OMAenol). Mediates the second step in gallate degradation pathway.
Sequence:
MGQTRIPCLLMRGGTSKGAYFLHDDLPAPGPLRDRVLLAVMGSPDARQIDGIGGADSLTSKVAIIRASQRDDADVDYLFAQVVVDEARVDYGQNCGNILAGVGPFALERGLVAASGASTPVRIFMENTGQIAVAQVPTADGQVEYAGDTRIDGVPGRAAALVVTFADVAGASCGALLPTGNSRDCVEGVEVTCIDNGMPVVLLCAEDLGVTGYEPCETLEADSALKTRLEAIRLQLGPRMNLGDVSQRNVPKMCLLSAPRNGGTVNTRSFIPHRCHASIGVFGAVSVATACLIEGSVAQGLASTSGGDRQRLAVEHPSGEFTVEISLEHGVIKGCGLVRTARLLFDGVVCIGRDTWGGPEK
The following text describes a protein:
Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Subcellular Localization:
Nucleus. Chromosome, telomere.
Sequence:
MAPTIKSSLTTLHEEIRKYDKRRHWNTIIRKSAHLSLVRNIFKKKRRQKLNYRHMSTFLASSENISNIRDTVVLLEINKLSQSILSSRNIFELRKLKPTRKMVEIEHCFVSKNDTFVACSKLISMFHLEKYIGSTNCANILEWITKMLNNGGYHKMKPFVYKEAPFTRAFRASKVMKNVDPNVKRNIQTSIVNNLKSGVHWWALMALRQVMIPIVIKEERVLLWRDGYLNILTKEIKDFKQRYIVQKAPHFIRPNVATFKLSISRQKLRPLFKRKAIDKKTETMQWKRLNSMLSWCLERSGVYRHTIRDSCKKVSDFLKKNSQNSKIIGYTADVSKCFSTVNHDVLISIIDRLFSQEHDIYTVCGKGRNHGGFHKLIFCSAGTELNAHEALRRKMELKGVFNFEVCYREMSSSTTLYSVIRTTLSTYYYKRGPTSWRITKGVPQGHPISSNLAHMYLNNFEQKYWSNEKEDSRIVFCRYEDDFIFITTENSLFEKMMKPLSTGNNTHFLTANPKKFKKSERCGASQVLQWCGVKLDFQSGNCFIRRRCKDGVARQFLIKLQ
The following text describes a protein:
Function:
Plays an essential role in early embryonic development.
Subcellular Localization:
Nucleus, nucleolus.
Sequence:
MTEGKSSDKPAKRLLALNPKEDAEFQKKVQQVKKRPQTGQTLSPGVLYVGHLPRGLFEPQLKSYFEQFGKVLRLRVSRSKKTGGSKGYGFVEFECDEVAKIVAETMNNYLMGERIIKCHVIPPEKVHEKLFVGSIAGFKKPKYPAVTRYNKTHTEDDVKKVGTKLLSKESKLRKRLAAKGIDYDFPGFAAQIPAKKAPSEANVSVCSEDVTPVCTPSLLERRKSLRVEDDDVDDEIVIKVKPLPENSDDVEESEEESAEEDEGEEEEAA
The following text describes a protein:
Function:
Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.
Sequence:
MSPKTTHYTPQLAVRYLHALRTDENERSRLFKPQGFRSWPFNTLSTDHPNDVIVSHATIFRLRLTANKKSRSSLAIPFCKLILSTQKPSVFIQTHKVIAMDDSVNQLLAEHQVVNYQLKSEAFDVIKQRRSANYKPNIWKYDFLQSLRSKYDGDEYKRRAEKLREKGKDLFVEAVEELAKLELIDMIRKLGLADLFAEEMQKTLQAVASSKKRKNSEEEEDLYITALRFRILRLHDYEVSQDVFNSFLDDKGKFSKSKSTEIKGLLELFEASYLAFEGESILDDAKTFATETLRNIYSTLDGNLAKEVAHALELSTHWRVQWFDVKWRITMYENNKNTDETLLELAKLNFNTVQATLQKDLSDISRWWKNLALMEHLDFTRDRLAESFLCAVGLAYEPRYSCFRKRLTKITTMILIIDDVYDVYGSLEELEQFTKAVDSWDTSKIQQLPESMKICFQALYDITNEIAYDIQEHNHPDVQALLHLRKAWAGFCKALFVESKWYNEGYFPSLQEYLSNALISSGGTVISVHSMLSVEHNIADDMVNLLGKNHDLVHNVSIIIRLCNDLGTSAAEKERGDAPSSILCYMREVDVSEEEGQEHIKDTITGAWKKINSQCLSSPSPLQQSFVKVTANVARMVHCLYQFGDGFGIQDRETRRHILSLLIEPFKLD
The following text describes a protein:
Function:
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
Sequence:
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLATYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEGEENKPNPVTQRVKIIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLTLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVTDDCCRREPTLVRNDQKFHTVEEEARINRERKVEVIKPLVAETDTSSRPTFVVGNSTLDSSLELEMQEPEIQIPSEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRILADGMTPVVRFPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLQMSVAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMVEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTSLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA
The following text describes a protein:
Function:
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
Miscellaneous:
MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
Sequence:
MTIQERLLEAVEQKLLRPIDAQFALTVAGNDDPAVTLAAALLSHDAGEGHVCLPLSRLTLTEEAHPLLVACISETATPIDWKKRLLASAAVSCGDSPAPLILCGERLYLNRMWCNERTVARFFNEVNQAIAVDEDQLSRILDALFPPTDEVNWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGAALRQLPLTDAQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDSLPPHGRVIFLGDRDQLASVEAGAVLGDICAYVNAGFTAERARQLSRLTGSAIPAGAGTQAASLRDSLCLLQKSYRFGSDSGIGKLAAAINCGDRSAIQAVFQQGFSDIEKRTLQSSDDYAGMLDEALAGYGRYLRLLHEKATPEAILQAFNEYQLLCALREGPFGVRGLNDRIEQAMVQQRKIQRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGLRVWFVMPDGTIKSVQPSRLPEHDTTWAMTVHKSQGSEFDHAALILPSQRSPVVTRELVYTAVTRARRRLSLYADERILAGAIVTRTERRSGLATLFDEVSRTG
The following text describes a protein:
Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular Localization:
Mitochondrion inner membrane. Mitochondrion membrane.
Sequence:
MGAAASGMQTQMQAEHDPNANFPWWVRFVAKGLGIVGGFVAIFFGILGLISLDPKCIFAMLLQLVGGCLSIALEAPFCCMFVDFIERIAQFSETRKYWHKAVLFGVMGIIPILICIELNSVLGSGMIFCCGVVYGFMALGKKADRQTMMAASDPAWSPQITQMGREEDKPVVEKIGEVGSKASGVFAQWWSLTTSDRRPKPVPERACTIDQLPIYPCDLPQTEYKFIPEEPLPLQREFATVRVSFLREYERVASRFSIVDSAVNKTTDAAMKVNRYVNEEWTVLPKAAAITVGGMAGFVLGLKRGSFGRLLTSSLGLVTMAAFCYPHEAVDVVRTGIAHSEQAWEGFKESPNPSEVKKVTKDALTPPK
The following text describes a protein:
Function:
Multifunctional cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2). Within the pathway, the multifunctional cytochrome P450 monooxygenase af510 acts as a 2,4,6-trichlorophenol monooxygenase that first performs the C-H hydroxylation at the bridgehead C5 position to yield 5R-hydroxyl-beta-trans-bergamotene. Subsequently, a four electron oxidation initiated at C-9 coupled to cleavage of the cyclobutane C5-C8 bond of the bicyclo[3.1.1] core yields the epoxyketone intermediate 5-keto-cordycol. An additional epoxidation reaction also catalyzed by af510 then furnishes the characteristic bisepoxide ketone 5-keto-demethoxyfumagillol. The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520. The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps. 5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene. The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin. Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (Probable).
Subcellular Localization:
Membrane; Single-pass membrane protein.
Sequence:
MAYELSTLQLSCVAFVAFMAVLVFRTRTRNLKQNVPPGPRPLPIIGNFFDLPPKGQPEYLHWFKHKDAYGPVSSINVMGTTLVIFHDKDAAHAVMGKKAQKTSARPQLNFAQLCGFENFLITHQYNDKYRLHRKMVHQEIGTKGLSAGFRPIQEQESIRFILQTFNRPDDILQHLKTLAAAIVLKITYGYSIERKGQDPLVELIEHAMENLSQAFVPLAWAVDSVPAIKYLPDWFPGMSYRKTARKWRAINEAAAELPYDFVKRQMAHKAHQPSYVSNLLEKHMIKSEDNKINVSAADEEAIKWTAVSLYAAGSDSTVAIIHSVICGLVMFPEVVTRAQEEIDRVVGSDRLPNFDDRTNLPYVDGIIKEAWRWNPVGPMGLTHKSEEDLVCGEYLIPKGSYLLPSLWWFLNDPKEYPEPRVFKPERYMEPFNHPDPSEIAFGYGRRSCAGRYFADASVYITVVQLLAVFNVRKARDDQGNEIPVTLQAIPGMVNRPAPFQFKVEPRSQHHIDLLRRIESEQIPEVSHASLLKPSTV
The following text describes a protein:
Function:
Can oxidize menadiol to menadione. May work in concert with MdaB to form a quinone redox cycle.
Sequence:
MLTVIAEIRTRPGQHHRQAVLDQFAKIVPTVLKEEGCHGYAPMVDCAAGVSFQSMAPDSIVMIEQWESIAHLEAHLQTPHMKAYSEAVKGDVLEMNIRILQPGI
The following text describes a protein:
Function:
Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MWHPLTIPDVVVPVLKIWHSCGLATFVLENGFFKYKKTNHFVISLLVMLSGLTVYVKVFGVGQNFRSYVTFLHFICIYLQNFALIWFSHRRREKINWVLNEMLSLEKRLVRFSGTTISFVSVGQYLLKYFLLQVILILIVVVAIFLIANLSVIFVIYVVTYYGSMIFGFNLGLFLLFYLLCLRELCKHFNASKITCFKKVRPIYMSIRELSKNFNKCFQGIVLFKIASDFVIAVTSFYLSIYSLKFTRSLVGGIFLLGVSGLSLTTIFIFPFSVAYLFEDLSKQEKLAKKLIVSLLTSSKDGQLSHKPLELFFLQTRHNKIEFNVCGMFLLNCTFIYMIISSMANYLIYTLQFYQVNRSGS
The following text describes a protein:
Function:
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSEALKIESRPIPAFYCCYLLRSKNRKSYYIGSTPNPARRLGQHNGSSKGGAKRTSMQGKRPWEMTCIVTGFPSKFAALQFEWAWQNTHATRHIDKDVRDARAEELQKGKKKATSPGRRRKRPPMSLEARLKNLHHLLSVDSFCRWPLNLRFFAPDVFVQWERHTTKMTTTLRKSITIQLTPAEIPKLASDVSTELQTHFIPEVIRAIPVAYEDCKQYIEKSRRVLEDDQRLGCGVCKNPADMSSSLILVCPIEACQTVSHLSCLSNKFLTEGGELETLVPLEGTCPGCRSCIKWATMIKELSLRTNGEEELKLLFKPKRKRKSDNPAESDAADGQALEQEDEELDETWMEDMSQDEEPSPVKKSR
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDGRPATADDVVEAMREFVWFPPPRPASEFFSRFSAPRSCSKWISRLECNLYYYGTNYFILILLIGMSFLQKPVAILTAFATGLSIAFFSDSFAVTSTNKVISIVRKFSPDLAAQMRPYINDYLIAWFYYYSFTRFLGELCLDCCQWHFSSVRHGRPSMKGSTHICGRPLSMWVFALFLFEVSCIFWASSCNFLIVPWELYVGLLVTLIHASFRERNLKGRLNRFRKEFREAW
The following text describes a protein:
Function:
Morning-phased transcription factor integrating the circadian clock and auxin pathways. Binds to the evening element (EE) of promoters. Does not act within the central clock, but regulates free auxin levels in a time-of-day specific manner. Positively regulates the expression of YUC8 during the day, but has no effect during the night. Negative regulator of freezing tolerance.
Subcellular Localization:
Nucleus.
Sequence:
MASSPLTANVQGTNASLRNRDEETADKQIQFNDQSFGGNDYAPKVRKPYTITKERERWTDEEHKKFVEALKLYGRAWRRIEEHVGSKTAVQIRSHAQKFFSKVAREATGGDGSSVEPIVIPPPRPKRKPAHPYPRKFGNEADQTSRSVSPSERDTQSPTSVLSTVGSEALCSLDSSSPNRSLSPVSSASPPAALTTTANAPEELETLKLELFPSERLLNRESSIKEPTKQSLKLFGKTVLVSDSGMSSSLTTSTYCKSPIQPLPRKLSSSKTLPIIRNSQEELLSCWIQVPLKQEDVENRCLDSGKAVQNEGSSTGSNTGSVDDTGHTEKTTEPETMLCQWEFKPSERSAFSELRRTNSESNSRGFGPYKKRKMVTEEEEHEIHLHL
The following text describes a protein:
Function:
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
Sequence:
MFIPVTNICRNRCGYCGFRREPGQPGARLMKPAEVISILKNGVRAGCTEVLFTFGEYAEEMPGYNLMLDEIGYSSTLDYLLFLCETAIETGILPHTNAGVMTRSELEALKPLNASMGLMLESTASLEAHKDCPGKIPERRLETIREAGKLQIPYTSGLLIGIGESREDRIESLEAITSLHREYGHIQEVIIQNFAPKPGTPMESFPEPTVEEMMDAVVLARHVLPSDVSVQVAPNLIDPKALIGKGVTDLGGISPLTIDWINPEAEWPDVRDLQKKLGDIPLRERLPVYPQYVKRGWYSERIGSLIERLSDNEGYRKQPAIENAEDLEK
The following text describes a protein:
Function:
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLFRIRRKIRVCPRALPSDQEPRSTPRTTPPIVPLGTVAALQVSACRATIRLSFVMIGAVCGRVGANAGGLLLGAHAGLAQTGGQALALSLPACAVQKGGRHARLSSSSPLSSTTFVRQSDGASPRHSYDCTPSAIAERVSSGNCTSTSASLCGSSTSCLHHPFAHDPRSASGVSPLTAPGSPVYNLCTQSTKGGPRLRPRSRHRLLPSSLRGGADGSGLRSGSWVGSNAWPGAWLLFGLSATGLATAEVAPGTGEDSGDVDDEWCAESRTGAAGAATCHAKDVLTNYRRIGVRGDGRCLFRAVAYGHNVQEKRGAQDSERDEQQADQLRNMALDELVRRRDESEWFIEGDFDHYVHRMRHPGVWGGEPELLMLSHALKKPITVYIPDPSGAGILSIAEYGQEYGKAAIAVLYNGSTHYDALLVPAADHIAARL
The following text describes a protein:
Function:
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Subcellular Localization:
Cytoplasm.
Sequence:
MNNRVHQGHLARKRFGQNFLNDRFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDKLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTMNFGELSAQLGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKEYGRLSVMAQYYCQVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPYPVKDIRVLSRITTEAFNQRRKTIRNSLGNLFSVETLTEMGIDPAMRAENISVAQYCQMANYLSENAPLKES
The following text describes a protein:
Function:
Involved in spore formation. Plays an essential role in the establishment of homologous chromosome pairing in early meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MKLKMNKACDIASISVLPPRRTGGSSGASASGSVAVAVASQPRSQPLSQSQQSFSQGASASLLHSQSQFSQVSLDDNLLTLLPSPTRDQRFGLHDDSSKRMSSLPASSASCAREESQLQLAKLPSNPVHRWNPSIADTRSGQVTNEDVERKFQHLASSVHKMGMVVDSVQSDVMQLNRAMKEASLDSGSIRQKIAVLESSLQQILKGQDDLKALFGSSTKHNPDQTSVLNSLGSKLNEISSTLATLQTQMQARQLQGDQTTVLNSNASKSNEISSTLATLQTQMQADIRQLRCDVFRVFTKEMEGVVRAIRSVNSRPAAMQMMADQSYQVPVSNGWTQINQTPVAAGRSPMNRAPVAAGRSRMNQLPETKVLSAHLVYPAKVTDLKPKVEQGKVKAAPQKPFASSYYRVAPKQEEVAIRKVNIQVPAKKAPVSIIIESDDDSEGRASCVILKTETGSKEWKVTKQGTEEGLEILRRARKRRRREMQSIVLAS
The following text describes a protein:
Function:
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MAAAATCGAGTLSSECVASEAGQSRTSSFQRRGKASGAPGGGPRLLSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTLLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKENPANILQELPAPLLDDNGKKELEDVHSAKPPEADANMKIAWRYQLQPRMEVGPVLSSRFGHYYDVSRRIPQELLESSNWHGFFLPEHTPPGLKGEPCFLSCGYMKLLQFFQNIIYTEGFDGANPQKKQKNILRIGIQNLGSPLWGDDICCKENSDNHHRLTKFLYILRGLLRSSLSACIITMPAQLVQNKAITTRVRNLSDTVVGLESFIGSERETNPLYKDYHGLIHIRKIPRLNNLTCDESDVKDLAFKLKRKLFTIECARASLAVLFLDRLSV
The following text describes a protein:
Function:
Component of an histone acetyltransferase complex.
Subcellular Localization:
Nucleus.
Domain:
The PHD-type zinc finger mediates the binding to H3K4me3.
Sequence:
MRTKQQQQQQQQSNSSSGVANNQKSYGYTTRIKSNSSVTNGGNVGATLTESRIITNINELLPGLNDISDAFEALPIDLIRYFTLLKEIDAKCINTIPQINHLINQYITNLHQDKNVTTTTTTTTNDDNTIDLNKKLETRRLNLIKNKINEVIPCLEEKMHVTSVASDLLKKHMYRINQDYKLILLNNEIPQSIRIGPLNHPAMINDTHTTSSSSTTSTGNGTGGGGGTNNNHGGNNSVQSQRSESRREALAARKANKEDDRENNTATGGSGRKKKKEQNNNNNSTASGADGNNGSNGKKRNRDDKSNNTGSGNDLKKKKKSNNNDQSDNRRRGEDENGKGDGETSFNSGNAKNDPHGKLKTTTTGNLVGGSSTTTTVSSSSTTSSSATTTTTSSTTTTKNSGSTGASTATATGASGAKGSSSSSSGNNEPTYCYCNQVSFGEMVGCDGDDCKREWFHLPCIGFKNPPKGKWYCDDCLKKLK
The following text describes a protein:
Function:
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Sequence:
MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREEYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKDKDMPYLKQMVQEVKALGMETCMTLGMLSAEQANELAEAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLSHVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAASIDDEQAVLAKAAAYQDKASAQFYDAAAL
The following text describes a protein:
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. Plays a role in brain, heart, and eye development.
Sequence:
DARGERGLSLYPETSLFFSLHLQEEGSKLPPPPTPAPTAPPAPAPLDKPIVLMKPREESKGPASGAGAPVPEGATPPPPVTPTPPKGEKEGQRPTQPVYQIQNRGMGATTPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHEASSSSGSDEGTEYYPHLVFLQNKARREDFCPQKLRQMHLVIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDAEGDSESLPRAGPGSSPLFSLLPGYRGHPSFQSLVTKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA
The following text describes a protein:
Function:
Transcription factor involved in the diauxic shift. In the presence of glucose, activates carbon and energy metabolism genes, and in te presence of glycerol-lactate, activates genes needed for cell wall maintenance. Binds to DNA elements with the sequence AAAAGAAA (A4GA3), a motif enriched in the promoters of AZF1-sensitive genes. Required for glucose induction of CLN3 transcription. Also required for proper FLO11 expression. May also function as a corepressor; As an intrinsically disordered protein, AZF1 is capable of forming the prion [AZF1+] that confers resistance to the drug radicicol in a gain-of-function manner but decreases the expression of AZF1's target genes.
Miscellaneous:
MISCELLANEOUS: Presentwith 556 molecules/cell in log phase SD medium.
Subcellular Localization:
Nucleus. Cytoplasm, cytosol. Note=relocalizes to the cytosol in response to hypoxia.
Domain:
The polyglutamine (polyQ) domain is required for transcription factor activity; The polyasparagine (polyN) domain plays a subtle role in transcription but is dispensable for localization and prion formation.
Sequence:
MPPPTAQFMGPTQAGQNESQNQSSGEAGEQNQEHGQGPTPILNQSQPASSQPQHQQQRNESISYYTNFNQPRYSTDASINSFLNISDNVPVTSTGGPSSGGAYSNLPRLSTSSTHQPPDLSQIGRGFSIVNNLFPQQQQLQNQHRQQQQQQQQQSHQQPPFKTPSFSTGLTGSSSQYQFLPRNDNTSQPPSKRNSVYLGPNDGPDFEFFSMQQSQQPQFQPSSRRESNSMRPPLLIPAATTKSQSNGTNNSGNMNTNADYESFFNTGTNNSNSNQNPYFLSSRNNSLKFNPEDFDFQFKRRNSFVRGTLDHSSQNAFIPESRLNSLSVNNKANGDPVADNVTNNMKGKSNEVDNDDGNDSSNNNNNNNNNNNNENNNDNNNDNNDNSINSATSTNIPNQEDHSLASTDTTSNSRKDLKEIEQRLRKHLNDEDNYSSAISRPLDKNDVIEGSEGLNKHIDESGMQPNIIKKRKKDDSTVYVKNEMPRTDPPMSKDNSTSAEGAAMANFSGKEPPIPDISSVSDDATNLIGATKVDQLMLIIQARKKGFTEKVNTTQDGDLLFNQTMDILPPKSELVGGVEKPKGTQNTRAVKKHECPYCHRLFSQATHLEVHVRSHIGYKPFVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLKPFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEYFASIYKNSNRGIKGRGKGVGTKKSTISSPENHPASTILNPNTNANNAIANDSENNGNPEGNIDSSSNSNPGSHSMISPTQKDMGTLQSQFIQNNFNNSVNSSNPSNQPIINYNYTTLPHSRLGSSSSSNTNNNNSNFSVGAAPGVLMAPTTNNDFSFNLDQSNDNERSQQEQVRFKNINYKS
The following text describes a protein:
Function:
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN.
Subcellular Localization:
Cell projection. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
KEEYEEEETDTFDMEIKVTDPEKVGDGMNAFMSYRVITKTSMPEFNSPETTVKRRFSDFLGLHERINAKYLHLGRIVPPAPEKSVIGMSKVKFSKEDSNSTDFIGKRRAVLERFLNRVAAHPELRKDPDFRQFLEADELPRAKDTAALSGGGLKRLVKSMGDTMFSLTTKMSESDQWFEEKQQQIETLDQQLKKLHHNVEILVMHRKELSISTASFAKSAAMLSNAEEHTSLSRALTQLAEVEEKIEALHVEQSETDFFVFSELLKDYIGLISSVKACFQERVRAYSVWQHAQQTLTKKREALVKTELAGKNEKLPQAQEEVKEWEQKVEKGQEDFEAISKMIRKEMVRFENNRVKDFRAAIIKYLEAMMDTQQQLIKQWEGFLPEAKAIA
The following text describes a protein:
Function:
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA).
Sequence:
MENTQRPSFDCEIRAKYRWFMTDSYVAAARLGSPARRTPRTRRYAMTPPAFFAVAYAINPWMDVTAPVDVQVAQAQWEHLHQTYLRLGHSVDLIEPISGLPDMVYTANGGFIAHDIAVVARFRFPERAGESRAYASWMSSVGYRPVTTRHVNEGQGDLLMVGERVLAGYGFRTDQRAHAEIAAVLGLPVVSLELVDPRFYHLDTALAVLDDHTIAYYPPAFSTAAQEQLSALFPDAIVVGSADAFVFGLNAVSDGLNVVLPVAAMGFAAQLRAAGFEPVGVDLSELLKGGGSVKCCTLEIHP
The following text describes a protein:
Function:
Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular Localization:
Nucleus.
Sequence:
MNRNNSNGVGSSTGAGSSQSGIDNNNNNNNNSNNNNNRQQDESPNSKKVVKKQQQTIGERRELRKKYRTLIQDVSGNKSELILPSSDGLLRSLKKADNLYNNVLQAREAVLDSELLALASQFGVEQAQKFKVSLNGFDSFGLVNRYKERLTFYTDENNNNNSTINKTGWEKLSQLYHTHFHTVPDFDFMYGPINFEPEEKKVRAPRKLTQKDQPVGAAKHAEKITDTSNQVESETTSSRVQVMKQYIEKNPGKSFIDLVVDETSFAQTVENIFYFSFLLKDGHVKIAKDNEEMIIQTTLPPEEKDYQSKNAQLTHSVVKLDFNTWNDLKDISDLSFHMEEELQQFKNRRGGGGGGGSSTQTHTSTRK
The following text describes a protein:
Function:
Snake venom phospholipase A2 (PLA2) that causes irreversible neuromuscular blockade in chick biventer cervicis muscle preparations. The neuromuscular blockade is mediated by inhibitory action at the presynaptic motor nerve endings. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Miscellaneous:
MISCELLANEOUS: Negative results: does not show myotoxicity.
Subcellular Localization:
Secreted.
Sequence:
DLWQWGQMILKETGKLPFSYYTAYGCYCGWGGRGGKPKADTDRCCFVHDC
The following text describes a protein:
Function:
May be involved in protein-linked oligosaccharide phosphorylation.
Subcellular Localization:
Cytoplasm. Golgi apparatus.
Sequence:
MVFPRLVATGRRGSAGGSDHVVELGLEIESPPCVLYGPPTESAGALLSGLVTVHVQGAGAEAGGCVVARLTLVLEQQVTYGRPFVAGPLGSCAACRERRRELARWEVVAQAAELAGGRHAYPFSHLLAGELPATSTLGSAGATQIRYELVADAVYRAGGGEERRRELRLPVLVTRSILRGPDRNSLRVFPPTDVTATAVLPSVIYPRSTIPLELQLGGVCCADRRWRMRRLTWRIDEKVRVRSHACAAHRARLRALEEEVRAKTARNLKKPAKPIKRTPDMGPQVTVSVATVEDPLPFDAGSAAARQEADVGNMDDDADTQSAFIHPSDHAMQQELQELQARIRQQQLEEERKQETSHYIEEVRTIAGTDIRSGWKSDFSGSGKIELVMEIDCMKLNSGVTNPVNMVSTTSPYLARGQAPVNVTCDVEDPTLGISVNHLLLVEIIVAEEMLHYTNGQLLSKGEAQGEGEGQGEALAEAKPAGLAGSHADQRLAELSPMFANRNNSMFRASAEEHSPGLEPDGSTAGADKRIVGTPTGAARVLRMQFKLTMTERSGLGISWDDEVPPKYQQVKFLYPPSYDEAVSASVSEVSGSSRVVSGPESNPAVRAPVAASPTQPPAVREGPSSLGTSGSAARDMMFISESSTLCIGGESPSALPAVEDASLGHRVCVRKVSELLDTDRITQ