lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Together with gas2l2.S, regulates ciliary orientation and performance.
Subcellular Localization:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MCIALSHSLAALNSGIMSTHQGGSVRSIRPFKSSEEYLYAMKEDLAEWLKDMYHLEIIVDNFTEILENGSVLCQHANNVTEVAREFSVQYPQLAEKLQLPKSGVKLNMMAQPGTFLARDNVSNFIQWCRKEMDIKDVLMFETEDLVLRKNEKNFVLCLLELARRASRFGMSAPMLIQMEEQIEEEIREEMDLPPPEIPVPKPQRKLCDFKNLDQMVQHLVSRCTCPVQFSMIKVSEGKYKVGESSTLIFVRILRKHVMVRVGGGWDTLEHYLDKHDPCRCTSLSHKPAIKLGSLQKQVSAVHEVKTRLTPRLDNPSKVETTLIVSRSQSPLPPVEWRSYSSGRTRTTSSSNSLDNNENSPTFKMSPSDRRSMSTSYRAHERSATPSRKLFTEDNPEPQQLGNPQSVNFRHHHSTSSLASQLTGSEEENSCLSEVFSESQSRRQMGRTTVMSLKEPAMKEAFLSHTQSAHRKVMSATEQNNIQQGSRIVNQSINSQDSRPKTPSRFIRPPSPSKQIHFFHNQQNKGVEQNPKTQINSCTRSPSPVKQTSLTYKQEFTKRPATPSRISSQYKDGDKSAATEIIPSQDHIKSKPSVSSEERTIRTGRSTPTIHLNKNGITYREVSNLPPRMQPKPDALELSHSIERDCMYTPLPIDPEQEKQIYRSLEDEILTNIKVLEGDSEENHPENDSHGFNMLEKSTLPLNASTLKNPSGQGSVPRSGVYINTTWQSGACYDDVITELTKGHVKLNRVDVENWISKIPSKGMVKEAEEAHTSQRNQVRENGHTGAVSQRTIVRKKTPSTEIKGSKPKQLPSQRARQLALENKKKTVDNVSENQASTFSGDSGETVQEKIKLSQGLKPKRTLKKPERVPSIYKLKLRPKIRPRRDNRPEKKPSRIPTPVSYRQMPSRNNGKAVKRTQSYQANKTSAPQTLNESQSSTVILEDLDSDDKTLEHSAPSQAVETPVTIGNDQSKTEEEEESWV
The following text describes a protein:
Function:
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Subcellular Localization:
Cytoplasm. Endoplasmic reticulum.
Sequence:
MDPTLKELLHANLEWIFVGGKGGVGKTTTSCALATLFATTPISDAASPGGTRPRRVLLISTDPAHNLSDAFNQRFGPHPTPVKGLEESLAAMEVDPKNFTHGALMSSLTGAKSDGSASSLSAEAEADAAQHTASFARIGAVLKEAARTMPGIDEISVFAEILHYVRTLFYDLLIFDTAPTGHTLRLLALPQTLSSTFDKLMSLEGLAPMIEAASHLIGTNLGALGGACGDTAGSCEQATAAPSLSSAAPGEGSAAAASSQSRWCITADEVRSTALHWRQTMEEVQARFNDPNRTSFVCVCIAEFLSVYETERLVQELMKYNIGCDSIVVNQLVLKPSSEPPCRMCSARQKIQAKYLEQIDLLYEDFHVVKMPLLSDEVRGVPALKKFARFLQEPYSPDTHGYIDVQEPC
The following text describes a protein:
Function:
Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity); Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
Subcellular Localization:
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.
Domain:
The C-terminus (head domain) is involved in binding the cellular receptor.
Sequence:
MVAEDAPVRATCRVLFRTTTLIFLCTLLALSISILYESLITQKQIMSQAGSTGSNSGLGSITDLLNNILSVANQIIYNSAVALPLQLDTLESTLLTAIKSLQTSDKLEQNCSWSAALINDNRYINGINQFYFSIAEGRNLTLGPLLNMPSFIPTATTPEGCTRIPSFSLTKTHWCYTHNVILNGCQDHVSSNQFVSMGIIEPTSAGFPFFRTLKTLYLSDGVNRKSCSISTVPGGCMMYCFVSTQPERDDYFSAAPPEQRIIIMYYNDTIVERIINPPGVLDVWATLNPGTGSGVYYLGWVLFPIYGGVIKGTSLWNNQANKYFIPQMVAALCSQNQATQVQNAKSSYYSSWFGNRMIQSGILACPLRQDLTNECLVLPFSNDQVLMGAEGRLYMYGDSVYYYQRSNSWWPMTMLYKVTITFTNGQPSAISAQNVPTQQVPRPGTGDCSATNRCPGFCLTGVYADAWLLTNPSSTSTFGSEATFTGSYLNTATQRINPTMYIANNTQIISSQQFGSSGQEAAYGHTTCFRDTGSVMVYCIYIIELSSSLLGQFQIVPFIRQVTLS
The following text describes a protein:
Function:
May play a role during cell division.
Subcellular Localization:
Cytoplasm. Midbody, Midbody ring. Cleavage furrow. Note=Distribution is highly dynamic during mitosis. Not detected during interphase, localized to cytoplasm during metaphase, to cleavage furrow during anaphase and telophase, and to midbody ring during cytokinesis.
Sequence:
MEPEETLESESSEKSLFSSQQEYEESQEAEETGAENPLLQPTLTGDVEGLQKIFEDPEHPHHEHAVQLLLEEDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQVECVNFLDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKNEWLESHPEASISEIFEQKQQLEDIVSPILAKMSTPRHFAAS
The following text describes a protein:
Function:
Choline transporter.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MIIDSTLVVKITFYASMVIFISLTFTSILFGQPEKLTRGFDPDGIACGADFGSKEYPYIYFSNPTPSTQYQSVCVKSCPKPDRQNTMPTQLECVPNSIVQQCKAKFSIDNPDDQFLIYDTFLYKGNICMPRNLAYYEAIKDIATPPSRLTNTSDVFYNKWMLLIYIILAGIASKLLLVQLKANTQYSVWGLTLGLFVFVGSLGIIFISQVREAIKNSLETNSISSFQVDEEYILKMTNVPDPINLIFLSFVFVILTFYGAYFLYNNYDRIKNLSELFEQVEKFMAEHEYLQEFSYPMIIVLNFFLFLTIYTVLSLRACFVIDFQQIGPFEKIQGGVLYYFQFLIYIFFFWGVQVIFGLNNYIISSSLVQWIQVGHVHNQEQELQYNHNQSSLVLTRYFLQEAFYNIGKITFASLLLLISPVKFVCDALKDWAVRRKNEKFRNFLVKYCCLPFIEIYNKTRQIEEVVYVELAINRKKNLSINLCLKFIDEYLELKQEDSSTAEIFEQLRNTVDSFLLITKIFIALFCAIICKVILGFKYFSKEMYETNLTCLVAAMIGYYVASLYFQTYSIVLQGFGYIYLRTMNICKKNNENFEKNQQKKKDNAFDTFKNLFKEFSDIMIQYENKLKEQKNEELPI
The following text describes a protein:
Function:
Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MNFWNFLEILLFIGIVAAGLIVAVMIKTAEDTTLFDRTQLPEDNPQKLNYYVQPPPNGDEKVPFPTVFEPAKVYTTFVVPAYNEEKRIPKMLDETVEYLKSREAKDKSFTWEIVVVNDGSKDKTKEVVLNYAKDYPNIFLLNQPVNMGKGAAIQAGCLHARGELVLMVDADGATKINEFEALETEIKKLMKNNNQAIVVGSRAQNEKANRTPIRKFLGLGMHVLIVLSGVRGIHDTQCGFKLFSREACKMLFMNQHVQRWCFDPELLVIGRRLGMKISEIPVEWNEIEGSKMKISGMIKMAIDLIDIAIFHRVGAWTIRDRRINK
The following text describes a protein:
Function:
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8. Finally, ATG1 is also required for the maintenance of cell viability under starvation and for glycogen storage during stationary phase. Plays a role in genome stability through suppression of abnormal mitosis under starvation, and in regulation of filamentous growth.
Miscellaneous:
MISCELLANEOUS: Present with 1070 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Formes punctate structures in starvation conditions only when ATG13 and ATG17 were both present. Localizes to both the isolation membrane (IM) and the vacuole-isolation membrane contact site (VICS) during IM expansion. The IM is a membrane sac generated from the pre-autophagosomal structure that ultimately expands to become a mature autophagosome.
Domain:
The LIR motif is required for the interaction with ATG8 and for the association of ATG1 with autophagosomes.
Sequence:
MGDIKNKDHTTSVNHNLMASAGNYTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCERTSTDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPPFRASNHLELFKKIKRANDVITFPSYCNIEPELKELICSLLTFDPAQRIGFEEFFANKVVNEDLSSYELEDDLPELESKSKGIVESNMFVSEYLSKQPKSPNSNLAGHQSMADNPAELSDALKNSNILTAPAVKTDHTQAVDKKASNNKYHNSLVSDRSFEREYVVVEKKSVEVNSLADEVAQAGFNPNPIKHPTSTQNQNVLLNEQFSPNNQQYFQNQGENPRLLRATSSSSGGSDGSRRPSLVDRRLSISSLNPSNALSRALGIASTRLFGGANQQQQQQQITSSPPYSQTLLNSQLFHELTENIILRIDHLQHPETLKLDNTNIVSILESLAAKAFVVYSYAEVKFSQIVPLSTTLKGMANFENRRSMDSNAIAEEQDSDDAEEEDETLKKYKEDCLSTKTFGKGRTLSATSQLSATFNKLPRSEMILLCNEAIVLYMKALSILSKSMQVTSNWWYESQEKSCSLRVNVLVQWLREKFNECLEKADFLRLKINDLRFKHASEVAENQTLEEKGSSEEPVYLEKLLYDRALEISKMAAHMELKGENLYNCELAYATSLWMLETSLDDDDFTNAYGDYPFKTNIHLKSNDVEDKEKYHSVLDENDRIIIRKYIDSIANRLKILRQKMNHQN
The following text describes a protein:
Function:
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Subcellular Localization:
Cytoplasm.
Sequence:
MWDQKWVIGNWKMNGRLQNNNALMHRFRIHPTAERVLIGLAAPTVYLLQLHNAMQIVLNNRILTCAQDVSRFPNNGAYTGEVSAEMLADTGTDIVLIGHSERSLYFGEKNEIQRRKMENVLNVGLIPLLCVGESLEEREAGKEHEVIAHQLSILQGLDTKNIAVAYEPVWAIGTGKVATVEQIADMHAFIYKEILSLCGSDVKIRVLYGGSVKADNAADIFAVPYVDGALVGGASLSYDSFTAIISAAQNA
The following text describes a protein:
Function:
Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondary metabolism. Involved in the defense response against Drosophila melanogaster larval grazing.
Subcellular Localization:
Nucleus.
Sequence:
MFEMGPVGTRLPAMTSPAHNHYSYHSPTSSDRGRSRQNSDAMDIQSITEREPATRYAVAGGPAPWNRNGSPSMSPMYSNNSERNQFHEENGRTYHGFRRGMYFLPCDEQEQDRLDIFHKLFTVARVSESLIYAPHPTNGRFLDLGCGTGIWAIEVANKYPDAFVAGVDLAPIQPPNHPKNCEFYAPFDFEAPWAMGEDSWDLIHLQMGCGSVMGWPNLYRRIFAHLRPGAWFEQVEIDFEPRCDDRSLDGTALRHWYDCLKQATAETMRPIAHSSRDTIKDLQDAGFTEIDHQIVGLPLNPWHQDEHERKVARWYNLAVSESIENLSLAPFSRVYRWPLERIQQLAADVKSEAFNKEIHAYNILHIYQARKPLR
The following text describes a protein:
Function:
Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not that of non-cognate toxin LsoA.
Sequence:
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKIIDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
The following text describes a protein:
Function:
Essential regulator of plant defense, which plays a central role in resistance in case of infection by a pathogen. It is a common target for both type III avirulence proteins from P.syringae (AvrB, AvrRpm1 and AvrRpt2) and for the plant Resistance (R) proteins RPM1 and RPS2. In strains carrying the appropriate R gene for avirulence proteins of the pathogen, its association with avirulence proteins triggers a defense system including the hypersensitive response, which limits the spread of disease. In contrast, in plants lacking appropriate R genes, its association with avirulence proteins of the pathogen impairs the defense system and leads to the pathogen multiplication.
Miscellaneous:
MISCELLANEOUS: Cleavage after Gly-152 by AvrRpt2 is critical for the release of RIN4 from the membrane and its subsequent proteasome-dependent elimination.
Subcellular Localization:
Endomembrane system; Peripheral membrane protein.
Sequence:
MARSNVPKFGNWEAEENVPYTAYFDKARKTRAPGSKIMNPNDPEYNSDSQSQAPPHPPSSRTKPEQVDTVRRSREHMRSREESELKQFGDAGGSSNEAANKRQGRASQNNSYDNKSPLHKNSYDGTGKSRPKPTNLRADESPEKVTVVPKFGDWDENNPSSADGYTHIFNKVREERSSGANVSGSSRTPTHQSSRNPNNTSSCCCFGFGGK
The following text describes a protein:
Function:
Weak apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Weak inhibitor of caspase activity.
Subcellular Localization:
Cytoplasm.
Domain:
The BIR2 domain is required for caspase-inhibition; The C-terminal region containing the RING finger domain is required for the initial degradation step, and the final digestion of cleavage fragments.
Sequence:
MSRWSVSQGCGNSHKALRMSGNREQLLSGWGAPGMLRPSMRSEAERQRSFRAWPRSCPQLSPVELARSGFYYLGPGDRVQCFSCGGVLRSWEPGDRPDTEHRKFFPSCPFLQQQQRGPGATDSVDGQVLGQLSGEEPDRTWEPVYPEMSEEQVRLGSFSTWPLDVPGSPEVLAGAGFFYTGHRDHVKCFHCDGGLQNWEQGDDPWTEHAKWFPMCDFLLQVKGEAFIRSVQESLFSSPEPSPESLGSYDYDRSLASSTESVSVPRAPTPGERSEPPKVSGPPLSTEEQLQRLKEERMCKVCMDKDVSMLFVPCGHLVVCTECAPNLRHCPICRAAIRGSVRAFMS
The following text describes a protein:
Function:
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MDFYNRNRQNVPMVLDWAIENYTCENVSRSDPSYACRSNSQCFNSPNGRGYLCNCSLGYEGNPYLDDGCQDVDECADPATNDCSKLPIAICNNTPGNYRCSCPPGMVGDGRESGSGCTARQKRQFVVLIQVTLGVGLGILFLVVVSLWLHLVFQKRKIKKLKEKFFQQNGGFLLKQKLSSCDKTVEAAKIFTTEELKEATNNYDETRILGRGGSGIVYKGILANNKVVAIKKSKIADGGQVEQFINEVVILSQINHKNVVKLLGCCLETEVPLLVYEFVTNGTLFHHIHDEGFKSSISWEDRLRIATDTALALAYLHSAASPPIIHRDIKSANILLDDYYTPKVSDFGGSRLVPLDQNQLTTLVQGTLGYLDPEYFFTSHLTEKSDVYSFGIVLVELLTGRNAIEFDRPEKERNLALHFVSSMKDGTVLDILEDRVRHEINGDQLQEVVKLAKSCLSVKGEERPTMREVAIELEGLRRSDKHPWVERDHEEVEYLLNAPLNSYTCNYSTDYHSLGVISPLDSGRVYQACSINEIPISTRRSKTPNQRYHHSSGTMMALVMLMIQLILLRPAMASVAKPGCQEKCGNITVPYPFGLDYPDCYREGYDLTCNHTFNPPKLFISTSNLEILEISPSLTQLRIYGFMGHDCYNRSGSKTESWYYWVNIDNLPYTFSDTHNRFTTIGCDTWSQITGSEGRNFTSGCYMACSDKESVINGSCTGIGCCQTSIPKGFKKFNVNVWSYENHTSVWNFNPCSYAFLVDYDWYRFSVDDLSHFYERYGDRLPLVLDWAIENETCETVSRIYPSYACGKNSDCYNSPNGLGYLCNCSQGYQGNPYLEDGCQDINECEDQNKNDCQGICHNTPGGYYCSCPPGTERDGTKNGSLCIASPTKFPVIQTAVGXGLGILFLLIGVSWIYWGFQKRRLLKLREKFFRQNGGLLLKQQLSSRDASMETANVFTAEELEKATNNYDTIRILGRGGYGTVYKGILPDNRLVAIKKSKIVDETQIEQFINEVXILSQINHRNVVKLLGCCLETEVPLLVYEFVTNGTLFHHIHEEGXKSSLSWEKRLTIAAQTASALAYLHSAASPPIIHRDIKSTNILLDDNYMAKVSDFGASRLVPLNQTQFTTLVQGTMGYLDPEYFHTSQLTEKSDXYSFGVVLVELLTGRQALSNLAIHFVTLMKEDKVDEILEDRVVNECSRDQLREVTMLAKRCLKLNGEERPTMKEVAIELEGLRRSDKHPWVEHNSEEVENLLGGTSDFHSSNAIGFDSLKDNVVIPLDGGR
The following text describes a protein:
Function:
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MTSGPVFFYILILGKYLVGSVPMQCVCRGLEVDCDETNLRAVPSVSSNVTLMSLRWNLIRKLPPDGFRKYHNLQKLCLQNNKIRSIPIYAFRGLHSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPLTFYGLNSLILLALMNNVLTHLPDKPLCQYMPRLHWLDLEDNHIHNLRNLTFISCGNLTVLVMRKNKINHLNENTFAPLQKLAELDLGSNKIENLPPQVFKDLKELSQLNLSYNPIQKIQADQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLANIIQRVFVWVVSAVTCFGNIFVICMRSHIRSENKLHAMSIISLCCADCLMGIYLFVIGAFDLKFRGEYNKHAQLWMDSIHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCLRPRKCRTITVLILIWTSGFIVALIPLTNKEFFKNYYGTNGVCFPLHSEDIESTGAQIYSVAIFLGVNLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVLKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHQFWYNYRQRRSIDSKGSQKTYAPSFIWVEMWPLQEMPPELIKPALFTDPCELSLISQSTRLNSYS
The following text describes a protein:
Function:
Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Activates the JNK signaling pathway. Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2. Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2. Dephosphorylates and thereby inactivates tyrosine kinase LCK. Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK. May play a role in B-cell receptor (BCR) signaling and B-cell function.
Subcellular Localization:
Cytoplasm.
Sequence:
MGSGMSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLQGEGCLVHCLAGVSRSVTLVIAYIMTVTDFGWEEALHTVRAGRSCANPNLGFQRQLQEFEKHEVRQYRQWLREEYGENPLRDAEEAKSILGKYKEQGRMEPRPSSRRWSSLSALPALTYNNYTTET
The following text describes a protein:
Function:
Plays an important role in primary cilium assembly, maintenance, and length regulation. Interacts with centriole inner scaffold proteins to promote proper centriole size and integrity and assembly of functional cilia. Required for the recruitment of both the inner scaffold protein POC1B and the distal SFI1/CETN2 complex to centrioles.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the inner scaffold in the central region of centrioles.
Sequence:
MLGSMARKKPRNTSRLPLALNPLKSKDVLAVLAERNEAIVPVGAWVEPASPGSSEIPAYTSAYLIEEELKEQLRKKQEALKHFQKQVKYRVNQQIRLRKKQQLQKSYERAQKEGSIAMQSSATHLTSKRTSVFPNNLNVAIGSSRLPPSLMPGDGIEDEENQNELFQQQAQALSETMKQARHRLASFKTVIKKKGSVFPDDGRKSFLTREEVLSRKPASTGINTGIRGELPIKVHQGLLAAVPYQNYMENQELDYEEPDYEESSSLVTDEKGKEDLFGRGQQDQQAIHSEDKNKPFSRVQKVKFKNPLFVLMEEEEQKQLHFEGLQDILPEAQDYFLEAQGDLLETQGDLTGIQSVKPDTQAVEMKVQVTEPEGQAIEPEGQPIKTETQGIMLKAQSIELEEGSIVLKTQDFLPTNQALLTKNQDVLLKDHCVLPKDQSILLKYQDQDFLPRDQHVLHKDQDILPKYQDQNFLPKDQNFLSRDQHVLPKDQDILPKYQDQNFLPKDQNFLSRDQHVLPKDQNILPKYQGQDFLPKDQDFLSRDQHVLPKDWNILPKCQDQDFLPRDQGVLPKDQNILPICQDQDFLPRDQGYLPKDQNILPICQDRDFLPRDLHVLSNDQNILPKCQDQDFLPKYQKVHFKEPYSDMTDEKGREDFSLADYQCLPPKSQDQDDIKNQQPASFMREERVREELPLDYHQYVVPKIQDQDSPREQNKHIKLPSSFEKWEIARGNTPGVPLAYDRYQSGLSTEFQAPLAFQSDVDKEEDKKERQKQYLRHRRLFMDIEREQVKEQQRQKEQKKKIEKIKKKREQECYAAEQRILRMNFHEDPYSGEKLSEILAQLQLQEIKGTREKQQREKEYLRYVEALRAQIQEKMQLYNITLPPLCCCGPDFWDAHPDTCANNCIFYKNHRAYTRALHSFINSCDVPGGNSTLRVAIHNFASAHRRTLKNL
The following text describes a protein:
Function:
Binds ssDNA with nanomolar affinity but no sequence specificity.
Sequence:
MAIITVTAQANEKNTRTVSTAKGDKKIISVPLFEKEKGSNVKVAYGSAFLPDFIQLGDTVTVSGRVQAKESGEYVNYNFVFPTVEKVFITNDNSSQSQAKQDLFGGSEPIEVNSEDLPF
The following text describes a protein:
Function:
Involved in succinate export with YjjB. Both proteins are required for export. Contributes to succinate production under both aerobic and anaerobic conditions.
Miscellaneous:
MISCELLANEOUS: YjjPB constitutes a split-type ThrE family transporter.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MQTEQQRAVTRLCIQCGLFLLQHGAESALVDELSSRLGRALGMDSVESSISSNAIVLTTIKDGQCLTSTRKNHDRGINMHVVTEVQHIVILAEHHLLDYKGVEKRFSQIQPLRYPRWLVALMVGLSCACFCKLNNGGWDGAVITFFASTTAMYIRQLLAQRHLHPQINFCLTAFAATTISGLLLQLPTFSNTPTIAMAASVLLLVPGFPLINAVADMFKGHINTGLARWAIASLLTLATCVGVVMALTIWGLRGWV
The following text describes a protein:
Function:
Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. Activity is pH dependent.
Miscellaneous:
MISCELLANEOUS: Mai-2 and tin-9.2 are transcribed on a dicistronic transcript where exos-4.1 is the upstream transcript and tin-9.2 the downstream.
Subcellular Localization:
Mitochondrion.
Sequence:
MLSVSRAATRMTGMVARFSAGGHGDGAGRGGGSGGSIRDAGGAFGKMEAAREDEYFYKKQKAQLQELREHIQEEVKHHEGQLENHKKVLERHQQRISEIEAQERALGKE
The following text describes a protein:
Function:
Major phosphoribomutase that converts ribose 1-phosphate to ribose 5-phosphate. Involved in ribose salvage via the pentose phosphate pathway.
Miscellaneous:
MISCELLANEOUS: Present with 4960 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLQGILETVPSDLKDPISLWFKQDRNPKTIEEVTALCKKSDWNELHKRFDSRIQFGTAGLRSQMQAGFSRMNTLVVIQASQGLATYVRQQFPDNLVAVVGHDHRFHSKEFARATAAAFLLKGFKVHYLNPDHEFVHTPLVPFAVDKLKASVGVMITASHNPKMDNGYKVYYSNGCQIIPPHDHAISDSIDANLEPWANVWDFDDVLNKALKQGKLMYSREEMLKLYLEEVSKNLVEINPLKLEVKAKPWFVYTPMHGVGFDIFSTIVKKTLCLVEGKDYLCVPEQQNPDPSFPTVGFPNPEEKGALDIGINLAEKHDIDLLVANDPDADRFSVAVKDMQSGEWRQLTGNEIGFLFAFYEYQKYKSMDKEFQHVHPLAMLNSTVSSQMIKKMAEIEGFHYEDTLTGFKWIGNRAILLEKKGYYVPFGFEEAIGYMFPAMEHDKDGISASIVFLQAYCKWKIDHNLDPLNVLENGFKKYGVFKEYNGYYVVPNPTVTKDIFDYIRNVYTPEGASYPSSIGEEIEVLYYRDLTTGYQSDTINHKPTLPVDPTSQMITVSARPSNGSENEHIRFTIRGSGTEPKLKVYIEACANEEQRASFLAKLTWNVLRREWFRPDEMNIVTKF
The following text describes a protein:
Function:
Involved in the biosynthesis of volatile esters which confer kiwifruit flavor (By similarity). Alcohol acyl transferase that can use a wide range of alcohols as substrate to produce esters (By similarity). Exhibits acetyl-CoA:alcohol O-acyltransferase activity (By similarity).
Sequence:
MASSVRLVKKPVLVAPVDPTPSTVLSLSSLDSQLFLRFPIEYLLVYASPHGVDRDVTAARVKAALARSLVPYYPLAGRVKTRPDSTGLDVVCQAQGAGLLEAVSDYTASDFQRAPRSVAEWRKLLLVEVFKVVPPLVVQLTWLSDGCVALGIGFSHCVIDGIGSSEFLNLFAELATSRAKLSEFQPKPVWDRQLLNSAGRTNLGTHPEFGRVPDLSGFVTRFAQERLSPTSITFDKTWLKELKNIAMSTSQAGEFPYTSFEVLSGHIWRSWARSLNLPAKQVLKLLFSINIRNRVKPSLPAGYYGNAFVLGCAQTSVKDLTEKGLGYCADLVRGAKERVGDEYAREVVESVSWPRRASPDSVGVLIISQWSRLGLDRVDFGLGRPVHVGPICCDRYCLFLPVRDRMEAVKVMVAVPTSAVDRYENLMRSPYS
The following text describes a protein:
Function:
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLSQSENKLQTAQQQPLQPLQQQQPQQPQQQQQQQQQHAQQSAAAPPSLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHPEAEEKQAESRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLEPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKELSSSISKCMEMKSSILARQKEMRSSLDKVKRLIRLVHGVDLCRPVDSEATAGALSNGPDCTPPANAASTPAPSPSSQSCTANCNQGEETK
The following text describes a protein:
Function:
Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (By similarity). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (By similarity). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (By similarity). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (By similarity).
Subcellular Localization:
Lipid droplet. Endoplasmic reticulum. Nucleus. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.
Domain:
The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid exchange and transfer.
Sequence:
MDYAMKSLSLLYPRSLSRHVAVSTAVVTQQLVSEPSRETPRARPCRVSTADRKVRKGIMAHSLEDLLGKVQDILKLKDKPFSLVLEEDGTIVETEEYFQALPRDTVFMVLQKGQKWKSPSEQRKKKAQLSLSQKPTKKIDVARVTFDLYKLNPQDFIGCLNVKATLYDTYSLSYDLHCYRAKRIVKEMLRWTLFSMQATGHMLLGTSSYMQQFLDATEEEQPSKAKASLLPACLKMLQ