lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Forms tail fibers that play a role in primary attachment of virion to host receptors. Assembles with Tail fiber assembly protein to form fibers attached to virion tail tip. Fibers are about 35nm long and have a thin, uniform diameter. There are presumaby six fibers per virion. They bind in a reversible manner to host molecules, attaching transiently the virion to the host until tail tip interacts with LamB and injects viral DNA into the cell.
Subcellular Localization:
Virion.
Sequence:
MAVKISGVLKDGTGKPVQNCTIQLKARRNSTTVVVNTVGSENPDEAGRYSMDVEYGQYSVILQVDGFPPSHAGTITVYEDSQPGTLNDFLCAMTEDDARPEVLRRLELMVEEVARNASVVAQSTADAKKSAGDASASAAQVAALVTDATDSARAASTSAGQAASSAQEASSGAEAASAKATEAEKSAAAAESSKNAAATSAGAAKTSETNAAASQQSAATSASTAATKASEAATSARDAVASKEAAKSSETNASSSAGRAASSATAAENSARAAKTSETNARSSETAAERSASAAADAKTAAAGSASTASTKATEAAGSAVSASQSKSAAEAAAIRAKNSAKRAEDIASAVALEDADTTRKGIVQLSSATNSTSETLAATPKAVKVVMDETNRKAPLDSPALTGTPTAPTALRGTNNTQIANTAFVLAAIADVIDASPDALNTLNELAAALGNDPDFATTMTNALAGKQPKNATLTALAGLSTAKNKLPYFAENDAASLTELTQVGRDILAKNSVADVLEYLGAGENSAFPAGAPIPWPSDIVPSGYVLMQGQAFDKSAYPKLAVAYPSGVLPDMRGWTIKGKPASGRAVLSQEQDGIKSHTHSASASGTDLGTKTTSSFDYGTKTTGSFDYGTKSTNNTGAHAHSLSGSTGAAGAHAHTSGLRMNSSGWSQYGTATITGSLSTVKGTSTQGIAYLSKTDSQGSHSHSLSGTAVSAGAHAHTVGIGAHQHPVVIGAHAHSFSIGSHGHTITVNAAGNAENTVKNIAFNYIVRLA
The following text describes a protein:
Function:
Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Subcellular Localization:
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Sequence:
MTTVPNLKPPAQVAGLTTLDKNLFKKNITVPCLILKNVKISSVLPFVKNYLLKIENFKPVCNVTTGESHVYFNPEIIGAFSDLPPETQKLLNDLCVQLELKPLTLNYENFSIEGVFRAVLPPNVEGMSSFTKVGHIVHVNLREHLVPFKDIIGQVLFDKVPNCRTVVNKVGSIDNTYRNFQMEVLRGENDTQTHVRENKCVFEFDFAKVYWNSRLCTEHERIVNMIESGDVVFDVFAGVGPFSVPLARKKCQVFANDLNPESFKWLNHNFKINKVGENYFKSYNKDGREFILGEVKELLPKFSAKNVFILMNLPALAVDFLTTFVDLFSNDELPEFGKHPVVVVYCFAKGEDFINIAKKSLCEKIGRNVEEKITDVFRVRTTAKFWSKITYGNEKIPALALNPKNSVMGKNKKKLNSVFKVAGAKSLKLKAKAKAVKSELKQINNKNKAKITEIDKELVNLQEKVRNSTGDQKKETKNKTKLPSRQNVTKEVGEKSQDTLKQLNAMQL
The following text describes a protein:
Function:
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity). Required for structural integrity of granules in primordial germ cells (PGCs).
Subcellular Localization:
Cytoplasm. Note=Localizes to cytoplasmic RNA granules (By similarity). Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Sequence:
MSDVELVKKMLRAVLQSSKHGVAMARLQGDYRALTGEMIPFRKFGHDTLESFLRSIPGVVRLERSITGEVMCFAGVCEETAHIAQLVARQKNVKKTGCSKLLNFQMRARTSHLFSHNVKPRLSLRQPSNMTHPGRGSVTSFYSTQRKLYSNDLPSSRAPAWQMNRKSPVPEKTSVVPSKINTNIKTPLKKTSGTAAQQKPVNRADVELVQGRIKQLLQKYSSGVWLSKIPQLYKSMFQEELHIIQEVEKWTHICTVEKPGSNNIVDRLVYPVLEPVPKASPVPVKSPCKQSPNTALLKQPTLTQKTTRTFRTLAINIPQSTPKPQTPLSPTSPNSTMIDFTLSETPKTQSLSPITPPSTPPAHQPLTTELKQKLRQLLNKYSQGLWAHGLPQLFQEAFGCAFPQYVLEDLSLLADTCMVEYPMPDNRKRAILYTLPCQVQTQPRSRPPPLVLPCTSNPHVPPLIIPTADFHSVFVIEINSTNNVVVRFAGGGYSKSLEVMEEEMQNFYNNIGAGLCLLSPKIGQLVAVASSDGAMLRAQVHQLSEDKVKVYFLDHGFFDLVSRKTLFQLRDQFMTLPFQATTCQLAGLEPFSTDPVVLKTLQSLAVGRSLLAEIVEREDTPLVVLYDTSENDDVNVTAMCLKALQDKSMENPLQVNSVYTNVCVTNVCSDGSVYCQLPSRGQAKLKDIMDKIEAHFISQLTWELLVSRPFCGKVCLAKYKGKWARAEIINLHGSHVLDILFLDLGLPASLEVSELREIPPIFLKELITIPPQAIKCLLEDLNVDRAVWPPEAVLWLRETVHNKAPSCMKIVKLDETRTVHIYLFCGNEAQDIHDSVNRQLASCPFWKQDVYANKINKASELFLPDAGEPSGSSPAPSNALTLPPQLNLPLVGQNMDVFVSVACHPGHFVLQPWQDLYKLVVLMGEMVLFYNKQEVTTVDIQKNNVYAAKIDNNWHRVLVKGLLTNGLVSVYELDYGKYELINYTQLQPLIEEFRQLPFQGISAQLADVKKEVWCEEASMVFRNHVEKKPLVAQIESVEEGEWPWERKISVYLVDTTQENKDIWIHNIMKEFLDEISRDA
The following text describes a protein:
Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.
Subcellular Localization:
Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein.
Sequence:
MTTEIVTVLPTHDYPNTSFPTHDEGVCFVAATSSEVAAITKNRLFYGSLDMVSSQMVLLGEKNVSTLADPCEVMMFDHIGTLSIIHPVPSDLSDYYNFHKCTINIQARLMDLQPPMQPCTGAHPYVTVGNPHVLAFRAHIVQEGYTYDGNPKYILHIKLLEQRFSGMSHENFYDDYLTGKVSTVTVDVYNKGIFCVDMNPQTALIAVDCPPKKHIRVVKSTTACCKDLFKPRLMQNFTYLIDKNLYDPFFLGRKDIKQEDHPVPYKYEEWECPLLLYYDSPWIPSLELWENDAFVEYVPADFVLIEINGMHNYDYLLNEVEANCLSAAQNWTTQIQVDPDIHPTDAWSRYNYHSCKTHKGNHSLPSAASKYQVLNMNENNRVIFPQYSGIYVFKIVVVDPLYSYCNLNTTVSVYVHGALPKSEINVGKTLVSFLVLIFGSILMAYYFPKLMKENARMKSIWD
The following text describes a protein:
Function:
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular Localization:
Cell projection, cilium membrane; Multi-pass membrane protein.
Sequence:
MLLWLSLISTLLILPFILAYLGGSFWLKESFYWEQPQVVYAQQLLLLVQGISASTAAPITVMYSTNALFNQFMDPFVRMAAIKSWMVDFDADGVNDQILFNISVPVGADEQSQIRFYTQSMFFIDTASPLTGNSLYVDGDLQLIQRWPMQDKVDYMFTNPAINFTQAVGNDYAALTWPRIVSDYLDKDVRTTLVSPMPIWSTPRGSNDPFTITIKVRIPKDRIVYRPALLQVLKNGWIQYIACWVIVAAVLIPLYKYVLQHQIVATYVSIQTSVDRDAKHPAGFKRPLF
The following text describes a protein:
Function:
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Subcellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein.
Sequence:
MKLSALHQSYLNRRRSPLDSSVDASSKSFLAVFWLVLHCLCCLISLLLGFRFSRLVFFFLVSTPSSSNLYSPPFRPDLPPPRIDLTPSNATTAEAKTSSSRVVVGRHGILIRPWPHPDPVEVMKAHRIIERVQREQKAVFGAGAKGSRTVIAVTPTYVRTFQALHLNGVMHSLMLVPYDVVWIVVEAGGVSNETASIVGKSGVRVIHVGFDQRMPNTWEDRGKVEVLMRLRALRVVKEEKLDGVVMFADDSNMHSMEFFDEIQNVKWFGAVSVGILAHSGNAEEMVMSMDKRREMEEEESSSLSSLPVQGPACNATDKLIGWHVFNTLPYAGKSAVYIDDVAAVLPQKLEWCGFVLNSRILWDEAESKPEWVKEFGLLNENEGVESPLSLLNDPSMVEPLGSCGRQVLLWWLRVEARADSKFPPGWVIDPPLEITVAAKRTPWPDVPPEPPTKKKDQMSLSQGNNNVVVIPKHQQQQQQRSSKVRKPKRRSKRNKHEAKPTDTATQVSSSTKHHQERN
The following text describes a protein:
Function:
Envelope glycoprotein that binds to the potential host cell entry receptor IDE; In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips (By similarity); The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-VZV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses (By similarity).
Subcellular Localization:
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein. Host endosome membrane; Single-pass membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection (By similarity).
Sequence:
MGTVNKPVVGVLMGFGIITGTLRITNPVRASVLRYDDFHIDEDKLDTNSVYEPYYHSDHAESSWVNRGESSRKAYDHNSPYIWPRNDYDGFLENAHEHHGVYNQGRGIDSGERLMQPTQMSAQEDLGDDTGIHVIPTLNGDDRHKIVNVDQRQYGDVFKGDLNPKPQGQRLIEVSVEENHPFTLRAPIQRIYGVRYTETWSFLPSLTCTGDAAPAIQHICLKHTTCFQDVVVDVDCAENTKEDQLAEISYRFQGKKEADQPWIVVNTSTLFDELELDPPEIEPGVLKVLRTEKQYLGVYIWNMRGSDGTSTYATFLVTWKGDEKTRNPTPAVTPQPRGAEFHMWNYHSHVFSVGDTFSLAMHLQYKIHEAPFDLLLEWLYVPIDPTCQPMRLYSTCLYHPNAPQCLSHMNSGCTFTSPHLAQRVASTVYQNCEHADNYTAYCLGISHMEPSFGLILHDGGTTLKFVDTPESLSGLYVFVVYFNGHVEAVAYTVVSTVDHFVNAIEERGFPPTAGQPPATTKPKEITPVNPGTSPLLRYAAWTGGLAAVVLLCLVIFLICTAKRMRVKAYRVDKSPYNQSMYYAGLPVDDFEDSESTDTEEEFGNAIGGSHGGSSYTVYIDKTR
The following text describes a protein:
Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
Sequence:
MEAKKIIGLGSPLLDIQAEVPAEFLEKYGLTLNNTYFAEEKHLPLYEELINIPTHSHVPGGSALNTVRLSRWMAQAGQDQVKFIGCVGKKDKFANMLIEVTNSDGVTTLFDEQDQPTGKCGVLLCNKDRCLVPLIGAAAHLSEAYVDQHIEDIKTATVLFSEVYFLYPRAELTKKIYQIASESGVNTCLTLSSVNAVSDRFNEILAVLPYVDYLFGNEDEVEQFAKNLKFEGDLPSVMQQIAGYEKHGQRERVVVCTQGKKPTLIAKKTEVITVEVQLVDVSKIVDTNSAGDSFCGGFIAELLNGPDLVKCAKAGNYSASQTIQHEGSTIPKYAPEKTW
The following text describes a protein:
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
Subcellular Localization:
Nucleus.
Sequence:
MSSYLEYVSCSSSGGVGGDVLSLAPKFCRSDARPVALQPAFPLGNGDGAFVSCLPLAAARPSPSPPAAPARPSVPPPAAPQYAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLKASADGHPGAFQTASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVAPLQLPLSGTTPTKFIKNPGSPSQSQEPS
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Miscellaneous:
MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MDLLLGIVQGLTEFLPISSSGHLTLLSHLLKTDLNAYQTAVLHLGTLVSVVLFALDGIRRSLRSWRIILNLIVSTIPAGVFGVLFEKQIDQLFSSPRFLPLFFSATALILMFTRYSSSGEKRMENMSFLDALLVGIAQLFALFPGISRSGITVSSLLFMKYRSEDALQYSFLMSIPVVLGAGILGLGKGNVTILAPIFAFLSGLFALYVLSRSVRSGKIWQFSYYCLFVAILSYLAG
The following text describes a protein:
Function:
Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
Subcellular Localization:
Secreted.
Sequence:
MNGFLIFTLFLVPMYVGATWSAKYAVDCPESCNSNECKNPVHCKRMVLDDCGCCRVCAAALGETCYRTVAGMDGVKCGPGLKCQFFSEEDDFGDEFGICKECPYGTYGLECRRTCNCPSGICDRVTGKCLKFSFFQLAVSKPPNRRKLISHAENDMGSGDDNSVKEDFVNEKAIHSPIMKWLNPR
The following text describes a protein:
Function:
May be involved in transcriptional regulation.
Subcellular Localization:
Nucleus.
Sequence:
MDMKNNLALKKKRELLGGINKRKMTLRKYMDNLKQSECRLDITQITKCVFLGSLCLKPVPHLFDSPLLLEELDAKVGSVGTEFEYIEMKSVMSDKEAVTKDSVKRGLKKKTLNSPKIKKKTLKVKTDIRTTPNGYNSVKSESASELVEATTAMSPVLPVINTEETSPVLSSFQTEPSESMSTSEENQVETPFPDFLDIKLLNQNIKDIKGVNPDPFAFEEDEAERLRREPTPELILSDSDEDAIDQLMYNIMDIKVGPNVFDKDFFDMPPSDIEEDYEEYSNDSQENKNEPNTVITRGKKYSKRAPQCKICSQVFSTYMQLKKHKLAHDGDKPYFCLKCNENHQTLDQLIAHLRTHQGKRPYVCKKCNQGFKTLKGLESHHPVHVLKKVSSQKRVFRCEVCNKEFHKLCDLERHTRVHTGEKPSICNICNKRFQQAHNLNKHLLIHTQEKPYECDVCHKKFGRNDVLNRHLLTHSVKKPNRCEICMKSFIRVSQLLAHNKKHHTEMAS
The following text describes a protein:
Function:
Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase; Involved in mercury resistance. Acts as a mercury scavenger that specifically binds to a mercuric ion in the periplasm and probably passes it to the cytoplasmic mercuric reductase MerA via the mercuric transport protein MerT.
Subcellular Localization:
Periplasm.
Sequence:
MKKLLAALALAVVAVPVWAATQTVTLSVPGMTCAACPITVKHALSQVTGVEKTDVRFEQREAVVTFDDGKTSVQALTKATADAGYPSPVCLAASCRRWAVRAASRDRQSGRHHWSGLPEPVRRVVHPHPATGLRRRRAVRQCGRLAQASAVAPYRARPDRAAAGAGSRVCDARLWRAQRLAALSRSRHYGGDIALGPVLPGPTQRSKAMMTLKIDGMTCASCAEHVRQALEKVPGVRSAAVSYSKALADLTVDEGVSHDTLTAAVTTAGYHARVADVPPHSAGLPGKTPGSAETGGKRSGGDSALRVAVIGSGGAAMAAALKAAENGAQVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAYLRQTSPFDAGITATAPAIDRPRMLAQQQARVDELRHAKYENILDTSPNINVLHGEARFTGSHSLTITLTAGGERTVSFDRCLIATGATAAVPPIPGLKDTPYWTSTEALVNDAIPERLAVIGSSVVALELAQAFARLGSHVTVLARHTLLYQEDPAIGEAVTAAFRAEGIEVLEQTQATHVSHADGKFVVTTNHGELRADQLLVATGRAPNTGSLNVAGAGVQLDERGAIVIDGGMRTSAPDIYAAGDCTNQPQFVYVAAAAGTRAAINMTGGDVRLNLDTMPTVVFTEPQVATVGYSEAQAHRAGIETDNRTLTLDNVPRGGARGGRTHPDGRDRDPRKDDRAGPRRPAVPVPDNGRGAQARCADLLEGCEAALMLRGITCGGTTMNLARHTAELVERLAMANQLEGFADLFVVLLRELSKGAPVSPAALALALDWPIERVSVALEQAVSTEWDDYGNVVGYGLTLRETPHTFEVDGRRLYTWCAFDTLFFPALIDRTAHVVSRCAATGTPVSLTVTPTAIEDIEPTGAAVSLILPQNTPDIRAAFCCHVHFFASAAAGQQWAATRPGIEVVSVRDAFAVGRECAERLLGATCLRNAGSTNRA
The following text describes a protein:
Function:
Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May be required to stabilize the outer plaque of the spindle pole body (SPB).
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the meiotic outer plaque of the SPB, at the end of the meiotic spindles.
Sequence:
MNKDVDYQTFKKSLRKEFKKAVKTILNLQAYNGDLIRDFLALYIPYHVVFYNLSIMKKGSPLRIQTNNLLKEALAKILNFNLAMGPKHIIKIMKKDKADPETMNKLKLVLYIKLFQGVFGHVDKNYNLAFQSFRWCLQFIAYSKRTRLFASIADEQIGAFYELCELFISMLCCHCFLIDLKENEALVGNNLKNFIKRQNPNYSHGFDLNEETKSLQWHWSLDEVDVIEALYCVAFDAMDKITLKFSKVNENFVFSQFFQYCAEIEEMLAILRGKIWECECDVFGPRIGLLVDSNHMNETIQKNILSITFKLKNDPQIICCLNKILEGLLLSSGVQFKVIQFFYVLKLYYMQDNEYTFEASSEMDKLTIECLCIIENIIDACDNPDEVTDYQLPKVLLTAMEGKLLVAEKISEDNDCSESLDDYHPRTYQFRHPRIIIDKMKTKLKQKLRFDSPKDPETDDHWIEYWKYCYQDNIGNLPDILSRIYQTFTDPSN
The following text describes a protein:
Function:
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
Sequence:
MSATRKSRAGDEPLPRPPRGAPHTSDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGALKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPSKVPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPTKMPPPGGFLDARLKGRPHAPEAAQFAGKEQTYYQGRHLGDTFGEDWQRAPTRQGSLDIYSTAEGKTHMVPVGETPTYVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPMLSKAASVECISPVTPRAPDARMLEELNAEPWYQGEMSRKEAEALLREDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINYHLESSLPIVSAGSELCLQQPVERKP
The following text describes a protein:
Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MLDSTRSFVLFQLLLLFAVVLIYLRSTYPGSLEPQEVEHLKEPPPADRLVVLVRDGLSAQSFLANRCTNVPLLRELFLHQGLVGISRPETITYHSISPYISLFSGFNEDAASVARGWLGTPASIDSIFDRCKRSFAWTTTELISRFPKIERPRELSFETYGEGVTKSCSEMEDFVCRSVQRFLGGGSRLLLNTTGVIFFIHMTGVEPSCESLQRIQENVWNVYKSFEKTFPDQRTAYLFTSNLGDPQTKSEYSLAVESPFFLWGSGVNHIKSMPGRSFMANEAGLRLPLHVLNTPHLTALMSALLGVPPPVYSRGMLPKGMLNASLRYEANAMLINAKQLLAQARRLRELHPKRMPAFWLSFQMMDNFVKESLALKKQRRFRALLDYSCNYMPVLIKGMDYFKDYYRHVSITAVSFAGIAWIYCLRCHLTVGKKCRNLIEIQEVISSKRLVYARGFHRLLTGVLVIIMMLERIPLVVQAILLIPSLYWRTTLKILGERPKMVCRKSLMSTALLALICFGGFFRRYILAVGYLGFASYNNREAFKRRGHQFYLWLLLLLGLTVVSALPESLGCSQPGALMFSIFLTVLRPLACGVYLNLLTWLSNIPVLLAALEYILIGWHPWIMYLVSWIYLGFLVLWQRRNLQASEVFFFDLSTLYTLTCTSYESVVIQMLAMELQLALRMKLKRNESIGPKTAAHYILVYSWYSLFIIGSFPAFDDFLDILHETCFGYSPLTYGLVMVLKLILPWLLVLCIMAGNYKSLASYEQQIFVRLLLMNSAMSLVLLHGITNVGPWRDILSRFAEFAVVHVFPLVWLLLWRLTQLKVGSKWMSQLPNELL
The following text describes a protein:
Function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
Subcellular Localization:
Cytoplasm.
Sequence:
MADQTVVEKMSEMQVDASKKGGADGERKDGGKKKAKNTAGDSAGKSELSPPPQYIDERLSLYTKLKAEHDALTAERAAKESRPIKVTLPDGKVLEAESWKTTPYQLACGISQGLADNTVIAKVNNSVWDLDRPLEDDCSLQLLKFDDEEAQAVYWHSSAHILGEAMEKVYGGCLCYGPPIESGFYYDMFLDNNEGVSSNDFPCLENLCKKIIKEKQPFERLEIKKETLLEMFKYNKFKCRILNEKVTTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKLGREQDLFFFHELSPGSCFFLPKGAFIYNTLIEFIRSEYRNRGFQEVVTPNIYNSKLWVTSGHWQHYSENMFSFEVEKEIFALKPMNCPGHCLMFDHRPRSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCSMDQIEEEIKGCLHFLRAVYDVFGFTFKLNLSTRPEKFLGEPEMWDQAEKQLENSLNEFGEKWVLNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLAYVSHEGDDKKRPVIIHRAILGSVERMIAILTENYGGKWPLWLSPRQVMLVPVGPTCEEYAEKVKQEFHSSGFMADVDLDPSCTLNKKIRNAQLSQYNFILVVGEKEKTSNTVNVRTRDNKVHGECSVEECIQRLKRLKASRSRNAEEEF
The following text describes a protein:
Function:
Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity). Plays a role in protein N-myristoylation (By similarity).
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MATPFLPSGATTGDSGGELSSGDDSGDMESFQTPEAEGTRSLAELFEKAAAHVQGLVQVASREQLLYLYARFKQVKVGNCNTPKPNFFDFEGKQKWEAWKALGDSSPSQAMQEYIAAVKKLDPGWNPQVSEKKGKEGSSGFGGPVVSSLYHEETIREEDKNIFDYCRENNIDHIAKAIKSKAADVNMTDEEGRALLHWACDRGHKELVKVLLQYEAGINCQDNEGQTALHYAAACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKAVSLLLQRHRASKA
The following text describes a protein:
Function:
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Domain:
The F-box is necessary for the interaction with ASK proteins.
Sequence:
MSANEIPDELWRKILEIGVKSSTFSYKDLCCISISSRRLFRLSCDDSLWDLLLVHDFPNHIVSASSSSESPTKFIYMTRFEREKERKLAAHRRALLRKESEISEWGRRIRELEARLSDEAERLQSSSLQFSDLLKVRQASVALNVWQPEVVRGRQKQMVEQNAVPVEGRLRALEMEMKLCKQQIMGLNRALREVKHRYDIAIKELESMKYHPLRDYKSIRNGDQGSNGKTKKLKTSINYSGDQVSNGKRRKLKTSIDCKFMNISHFSSCSSVTEKFYSYSPKIIHEYIPENLLVL
The following text describes a protein:
Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
Subcellular Localization:
Nucleus. Chromosome.
Sequence:
MSQSTTTTTTTTAAPAVPTGPREATLDAGNFCKRVKILYDSWNSDSNLWKSANSLVLALGQPNESNPYQKVTSLQTWLFGYELKDTIIVFLEKEIYIVSTSKKINLFQKLSETEQVKTELSSIKFNFLTIDKSDKNKSNFEKLIGEATKAGSNIGVIIKETYIGDLALQWEAALNECPLTKVDITPALSSCLLVKDLQEQKNIITSAKITSKVLKSHILPKIETIIDKGERQTHNQLADYAADIFESPEKISSKLTVEHVDYSYVPIIQSGGIYDLRASASSDDNPLHFGTIIVSCGARYKNYCSNIARTYIIDPTSDQKKNYAILLNVQSNVIKAIKPDVTFSSLYEKAIQTIKESSKPELVDHFPKNVGYGIGIEFQESLAVLNATNSRTLKAGMTLNIACGFQKISNPEGKDEKSKTYSLLISDTVLLNDEGKVEVLTDVGKKASDVVYMLGGEDDDDDNDNDPSVKLELPDDVKGITGRTIETKEKSKSVEERRRDHQKMLEQKNLQEAENKIKAMTDPNGKKGTPEVDYTAITKLQPIYSSVGAYPQDIVKNKMYIDPKKETVLFPIFGYMVPFHISTIKNISKSEEYIRVNFNTPTSYTQEQIDAGFVPPQLMYIREVTYKVNDPKVLANNIRLIKELKKKFTTRETEDREKRNLITQEKLILLRGKFPRLPEVHARPTLSGARRTIGILEAHENGIRFNPTSTKDRTPIDVLYKNIKHAIYQQADQESMAVIHFHLHDALMIGKKKTKDVQFYIEISEMSQSLDVSSRFNDEEEEERRERALKEKINNDFKTFIKRVEEIAPEPGLEFDVPYRELGFYGVPNVSTVFIQPSVHCLLSILEPPFFVLTLDDVEIACFERAIRSLKNFDLSFVFKDYNRPPIRISVIPRNYFETVKEWLDSFNIKFYQSERNYNWKRIMDTIKSDVKKFHDDGGWSFLDLEEEEEEEDSGDDDYHSNSDESESSDYISSMSSGSDDDDEDSSEGENWEDLEQKAERDDKMKTFDETNKRKRDEKSVSSSNRPSSSKSGSSSSGGGGGGGGSSRSKSSSSSSKGSSSSSSKSSSSKRK
The following text describes a protein:
Function:
Directs RNA polymerase II nuclear import.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MLLRIKRKRNEDPIDTLLVAHSGKDKRLKAVADARVFKLLDSVESDHLDLKQSTTNDSTPLTNTIERLASRLRNSPKHASVSALDRRKEVLVSSKLAEAKAARYRIVEQNRKSFMNGTLNVIDIHKDTDDNMRDEIVCNLLPMVREYLNLSEGSEAAKSANIPLQADYTVQEDDVYDLYYYDEGGRVGTALQSSKVATLGVENGDLLDLFTNDDHSESDTDLDSQDSNAEDYYANDYPDEDEGLHYEDTASDDEDSDNEFYDEYSVRDRWNAHELPSDDL
The following text describes a protein:
Function:
Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Has a role in cell integrity and polarized cell growth together with the other PCL1/PCL2 cyclin family members.
Sequence:
MANTFKYYPETMGNSSGYPISLPFPKGSATSAVNVARQLPKYLGHVPSQSVHTQLPSMASLGYFNQPSSTYYAPPAPLQQHQQPPILPPPGLMYTSNNNSNVIPPPVQMIRDGQQQPQQSNQVNGGVSENLDYDISIMSKFIMENAFVAFNANYSTDDQTTDLFFKGISSVLNATRLPSATIFLAIDYLFKYINKLSNGIHSIGGNSINIIYQNTMIAFILANKFNDDKTFTNNSWSQATGILINVINDFERQWLRIFNWELYDSAFLYFEFVKNFEIFKQNQLKPAVAVPTLLSPIVNVGDTRNVNFNLKPTSTNNLLSPVSNYETPMLMPHNMFSSPSYQSNSRSEFSSMNGYYNYYNYNQPRLNYYQQFPNIYSSPISETQFDYDFYNFSSQQQQQQQKQHSLLPAAPQLPPPHVHNQSYGHHLGWKSMDDTINHSRFERNYFPYSAVY
The following text describes a protein:
Function:
Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity; [Isoform UL12.5]: Degrades host mitochondrial DNA.
Miscellaneous:
MISCELLANEOUS: [Isoform UL12.5]: Produced by alternative initiation at Met-127 of isoform UL12.
Subcellular Localization:
[Isoform UL12.5]: Host mitochondrion; Host nucleus. Host cytoplasm.
Sequence:
MESTVGPACPPGRTVTKRPWALAEDTPRGPDSPPKRPRPNSLPLTTTFRPLPPPPQTTSAVDPSSHSPVNPPRDQHATDTADEKPRAASPALSDASGPPTPDIPLSPGGTHARDPDADPDSPDLDSMWSASVIPNALPSHILAETFERHLRGLLRGVRAPLAIGPLWARLDYLCSLAVVLEEAGMVDRGLGRHLWRLTRRGPPAAADAVAPRPLMGFYEAATQNQADCQLWALLRRGLTTASTLRWGPQGPCFSPQWLKHNASLRPDVQSSAVMFGRVNEPTARSLLFRYCVGRADDGGEAGADTRRFIFHEPSDLAEENVHTCGVLMDGHTGMVGASLDILVCPRDIHGYLAPVPKTPLAFYEVKCRAKYAFDPMDPSDPTASAYEDLMAHRSPEAFRAFIRSIPKPSVRYFAPGRVPGPEEALVTQDQAWSEAHASGEKRRCSAADRALVELNSGVVSEVLLFGAPDLGRHTISPVSWSSGDLVRREPVFANPRHPNFKQILVQGYVLDSHFPDCPPHPHLVTFIGRHRTSAEEGVTFRLEDGAGALGAAGPSKASILPNQAVPIALIITPVRIDPEIYKAIQRSSRLAFDDTLAELWASRSPGPGPAAAETTSSSPTTGRSSR
The following text describes a protein:
Function:
Methyltransferase involved in methanogenesis from methylated-thiols. Catalyzes two successive steps: mediates the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M.
Sequence:
MVSEMTPTRRVMAAVLGGRVDYVPPANPLAQTTTELMQICNASWPKAHFDSKMMADLAAAPYEICGIEAARPQFDISLEAEVLGCKLDWNKPDRPPVTGPAYTDPADITWPDNLEEAGRIPVVLGAIEELRKRYDGMLPVIPVLTSPFTVAGHIAGVENLVRWTKTDPEKAHAFIEAATDFVIAYGKLQTAYGAHILFPADPSASGDLISGETYKEFVLPAHKRMAKEISCPLILHICGDTSKLLPYIKQSGIDCFSFDAVPVWYCRQVMGNEMSILGSLDVIDLMPNGTPEQVYNRTRECILQGADIVGTACDVSFGTSLENLRAYVRACKETPIPKYDDVEDIIRQIGVGIGRNMKENVLGGMQK