lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Required for normal Golgi morphology and function (By similarity). Ensures, when in complex with FPP3/VETH1 and FPP2/VETH2, the correct secondary cell wall (SCW) deposition pattern by recruiting exocyst components to cortical microtubules in xylem cells during secondary cell wall deposition.
Subcellular Localization:
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at vesicle-like small compartments at cortical microtubules.
Sequence:
MSDLVATSPSPSSAPRSATDFFSDPYDSHPLWFKPSLFLSPNFDSESYISELRTFVPFDTLRSELRSHLASLNRELVDLINRDYADFVNLSTKLVDIDAAVVRMRAPLLELREKITGFRGSVEAALFALRNGLQQRSDAAAAREVLELLLDTFHVVSKVEKLIKVLPSTPSDWQNEDANSMGRSSMNDENSTQQDGTTMRETQSMLLERIASEMNRLKFYMAHAQNLPFIENMEKRIQSASVLLDASLGHCFIDGLNNSDTSVLYNCLRAYAAIDNTNAAEEIFRTTIVAPFIQKIITHETTTNAAGTSEDELENDYKQIKHFIAKDCKMLLEISSTDKSGLHVFDFLANSILKEVLWAIQKVKPGAFSPGRPTEFLKNYKASLDFLAYLEGYCPSRSAVTKFRAEAICVEFMKQWNVGVYFSLRFQEIAGALDSALTSPSLVFIQDSDKESSLNLILRQSDTLLECLRSCWKEDVLVFSAADKFLRLTLQLLSRYSFWVSSALNNRKSNASPSPGCEWAVSATAEDFVYVIHDVNCLVSEVCGDYLGHISQYLSSSSTEVLDVVRISIEQGGVSLEKVLPLLTKTIIDVIVDKSVEDLRQLRGITATFRMTNKPLPVRHSPYVVGLLRPVKAFLEGDKARNYLTQKTKEELLHGSVSEITRRYYELAADVVSVARKTQSSLQKLRQNAQRRGGAASGVSDQNVSETDKMCMQLFLDIQEYGRNVSALGLKPADIPEYCSFWQCVAPADRQNSISV
The following text describes a protein:
Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression.
Miscellaneous:
MISCELLANEOUS: The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.
Subcellular Localization:
Nucleus. Chromosome. Note=Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin.
Sequence:
MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKLTAMSSCSRRSKLKEPDAPSKSKSSSSSSSSTSSSSSSDEEDDSDLDAKRGPRGRETHPVPQKKAQILVAKPELKDPIRKKRGRKPLPPEQKATRRPVSLAKVLKTARKDLGAPASKLPPPLSAPVAGLAALKAHAKEACGGPSAMATPENLASLMKGMASSPGRGGISWQSSIVHYMNRMTQSQAQAASRLALKAQATNKCGLGLDLKVRTQKGELGMSPPGSKIPKAPSGGAVEQKVGNTGGPPHTHGASRVPAGCPGPQPAPTQELSLQVLDLQSVKNGMPGVGLLARHATATKGVPATNPAPGKGTGSGLIGASGATMPTDTSKSEKLASRAVAPPTPASKRDCVKGSATPSGQESRTAPGEARKAATLPEMSAGEESSSSDSDPDSASPPSTGQNPSVSVQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLRHY
The following text describes a protein:
Function:
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Sequence:
MTLLMVAEKPFLAESIAKFLSLGPIHTRKGIAPSCLVHEFNCKFKGKITKAKMTSVAGHVYTCEFERAFQNWSVDPRDLFSCNVIKVEANPKTRIPAHLRNEANGCNGLVLWLDCDREGENICFEVMDNTVSYMTKTCKIYRALFSSITKKDIIEAFNHLGHPDDRLAEAVDCRQEIDLRVGVAFTRLQTKFLKERFPKLGDSLISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVIIEDHEGRNKTLKLDKRFDNKSEVEDIVKSCKGVQGKVIKMSVNELKKSRPVGLNTVEMLKVASVKLGLGPQDTMSIAEKLYTRGYISYPRTESTKYSSYFNFTDILNNLQQTNQFREKVQLIKQNGINIPYNGEDKGDHPPITPLNYPNEYLNDSEKKLFDFITNTFLASIYKDSTFQKVSVSVQIGNYTFNGSGKILKDPGFMKITNHYDEDDELKDSDLIKPTSFIEGNTVIPSMFDIVKGMTKCPDYLTEYELISLMEKNGIGTDASIPVHIQNIISREYVSLDTSKRTLRPTKIGLALARTLETVDKNLITPQIRAHIESMVSRIAEGKAQYENVLEEALDTFEQNYLIYKQNLKVLEDNFAPLYQVQEQSRLFSKCGKCGRILLKVIGDQTYLSCPTCSLKFNLPQNASYSQQTKCCPICKFEIIMTSSLKSTKKEMVCPGCYNEKNQFMKQDHSSCLQCSNPECKLSYERTKTCLCSVCGGVMCLSSLQNKWSCFCNTCDSHIEWIDNVKKALPNDEICGKCKSYHLVDLTMKDNTMTKGCMNCDSSIKKLYTIKAVILSNSTRKGRHYNTSKSRGGYTSHSKNNSRKHSSRTGK
The following text describes a protein:
Function:
Glutamate-gated receptor that probably acts as non-selective cation channel.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MSLSLAASNTVQGLRLLFPALIIYFLIILSYGVGAQNSSNVTNVGAIINGNSRIGKEQKTAMEIAAETFNNRSKTHKLILHFRNSSTDPFLAASAAEELIKEKKVEAIVGMETWQEAAQVADLVGNLAQIPVISFAAPSITPPLMQSRWPFLIRMAADGSAQMKCIADIVSAYHWKRVVVIYEDDGYGGDVGMLALLSEALQDVGSKIEHRLVLPQVSSLSNPNWVELEELLKLPTMQSRVYIVFQSSLPTVAHLFRVAEKMGLVGKESAWIITESITSLFDPHETSDISSTMKGTLGIKTYYAKNTNSFATFQKQFQTKYPEEGSPEPGIYALRAYDAIRIIAQAIGRMTSNNSTSLQLLLNTLFSNYTGLSGKMRFEAGEILYSPVLRIINIVDGKRFKELNFWTPDVGFSLEETGKIRDGDAGGVIWPGNLTHVPKGWAMPTAAKPMKIGVPGKTSFSKFVKVDPSLENSDKKKYVGFCIAIFDMVIERLNYSLPYEFEAFDGLYDDLVERVHNKVYDAAVGDITVLADRLEKVEFTQPYMESGLSMIVPAKPEKSTWMFMKPFTWQMWVVSGAILIYTMFVVWFLERPSNPEFGGPLKNQIGTATWFTFSSLFFSHREKIYSNLTRLVVVVWLFVVLILTSSYTANLSSMLTIQRLKPNVTDIEILKRTNSKIGCDGDSFVMDYLQTVLGFKIENIVKVSSEYNYTKEFKSKNISAAFLELPYAQVFMNEFCEGYTSTEPTYRFGGLSFIFQRGSPIARDFTKAILELLENGELKKLQNDWLTPNECPNNVTSNGPESLSLNSFTALYVISGVTSSFCFLLSLAVLGRRFLQQEADQGNASPSPSDETLWNKTVRIARFFYSRELNIPTRAPTFADYAEEWHSPMWDYSTASNTPEHPRTIRPTEIECVQQG
The following text describes a protein:
Function:
Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO(2).
Sequence:
MTILAKEEHALREEMVRIAASFFQRGYATGSAGNLSLLLPDGNILATPTGSCLGNLDPQRLSKVDPQGEWLSGDKPSKEVRFHLALYRNNPCCKAVVHLHSTWSTALSCLEGLDPQNVIRPFTPYVVMRMGDIPLVPYYRPGDDRIARDLAALAARHQAFLLANHGPVVCGENLQEAANNTEELEETAKLIFILGERPIRYLTTEEIAQLRR
The following text describes a protein:
Function:
Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size. Facilitates the formation of large-sized LDs and modulates triacylglycerol accumulation. Induces probably a reorganization of the endoplasmic reticulum into LD-forming domains.
Miscellaneous:
MISCELLANEOUS: Knockdown mutants have a reduced accumulation of oil per seed and a reduced overall seed size.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized to the lipid droplet-forming sites.
Domain:
The N-terminal domain (1-98) determines the lipid droplet size.
Sequence:
MRILQNKTMKEQDNQLKIPEPLRADWFMVLVTIQADLIYNALVVLSSPFFLLYRSYRRAVVTVSAAEKAVKRAPAQIAGGAGRVVRRTWFGILGACHVSMVMVLALILAVVIGVGIVSLYVEKPVVVRDRLFFDYTEENPSAVFSFDKKKRSFSVPVGHSVHVSLVLWMPESEINRRIGVFQLKVELLSLKGETIARSSQPCMLRFRSKPIRLARTFVMSVPLIAGIANEAQTMRIDALKHQEKMPRTKAVRATLIPRAQTRTLPQLYEAEIVINSKPPWIKRMAYNWKWTLCVWTSMYLYVAILTALLWCFRPVLFPYTSSRTISESENLEIEVVEEEQEQVMERRRRERRNQPRRRNFATTQKSYT
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MATPETRGVDSDLETAEKIILRWDSTTSEEAKENLIFQSGGDREEVDRYLKAVDEVQRHISSISISDEVKATIQIAMARLEDELRNILISQTSTFEPDSLLLDSSLSSSSFASSSRTELEDDTCDDGNEEEEQQQVDLVLPDGSGSDSGSRRLSRSRRSNSKSTSSIREIDLVTPEAVSDLRSIAQRMIGAGYSRECVQVYGNVRKSAMEMIFKQLGIVKLGIGDVQRLDWEAVEVKIRRWIRAAKVCVRVVFASEKRLCEQIFEGTMEETCFMEIVKTSALQLFNFPEAISISRRSPEKLFKILDLHDAITDLLPDMEEIFDSSSSESILVQATEIQSRLAEAARGILTEFENAVFREPSVVPVPGGTIHPLTRYVMNYLNLISDYRETLIDLVMTKPCRGLKCTNDRNDPDMDISELEGISPLALHMIWTMVMLQFNLEEKSLHYRDEPLSHIFVMNNVHYIVQKVKSSPELMELIGDKYLRKLTGIFRQAATKYQRATWVRVLNSLRDEGLHVSGSFSSGVSKSALRERFKAFNTMFEEVHRIQSTWSVPDTQLREELRISLSEHLIPAYRSFLGRFRGHIESGRHPENYLKYSVENLETAVLDFFEGYTTAPHLRRSQ
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MLARQQPRRVARELSLLSLSQLSRKDTKPETLEQGDLEALLLAATRTLSGEVHEILETASAELSRSHERLLNSEIRASNLNSAKAMLEEAMTLTETVINRLALAVDLPETLQLAGQMEVRKFALELIGTVCRRRQQIDEQLQEAMVDWQLSRLAKIDQDILRLAIAELDYLGVPQKVAINEAVELAKRYSGQDGHRFINGVLRRVTEKKTDGAPVTPGEPR
The following text describes a protein:
Function:
May be involved in neurite outgrowth.
Sequence:
MGSAKEPETLQFLKQEALPEDAHQTRSPCSPEKDRCLQNLQCDGGHLAMRNCCINDLSTKESSQDNTMVDNLYQKEKSPAANLKPSVDQHATTNTIVLKDISAGGTPLEVEGEQSTSHDLCHNSQQVLSLTESPGNPVNTCSHLETKVSPVTGEACKHPLAESNLKEANKDSASTPSSSKHVGFLESSKDKDETDSITTGTGHSKASSALATCLKNTSQGQLHDSSGDLPNSSHDICGTAEHFSEGHRNSLVLGATKESVTKPFGAEATPRESDKPVTESDQLDQSGEIRSVALDNKKDRDSSTALGVPIAVISRNVQPQDLTPGELQAIPDKATKESERLREAAPDDAKCQKQAQEQQRPESGCMAAFKEHTTAVETRHGEPLVKTCSIEVTPSQHDAGTQADNRVSLVSVAVSPINPPDGSTAFTFHGRGLGGPSLKSPGLEQKPAKKDVEMQVSIPVETRSVATGPMTPITKSPQASYPEVHVKGAVEETPEPVKEVSWDEKGMTWEVYGASMEVEVLGMAIQKHLEKQIEEHGRQVVMTPQSTRSSSIKGAPQKAEVKRQPSVFRSLLQNVRRPRCCSRGGPAVE
The following text describes a protein:
Function:
The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular Localization:
Nucleus.
Sequence:
MFTKTAIELIKELRGTDSIPHYNDTSIKATIDEMIALYEDLIKTITEHKEQKKEPFYLQHAITFHNSINRDKRCILAYLNERLNRIKEYRWSSGQSLLPDQLKERLSQNEIQFFSEYDKILTEYNSKVGLDLTIDPQPPKELYIEVRVIKELGEVVLNSGCTVNLNLNTTHFLKRSDITNLVKNGSLEHII
The following text describes a protein:
Function:
Transcription factor (By similarity). May play a role in pharyngeal cell differentiation (Probable). May have a protective role in response to infection by the Gram-negative bacterium Vibrio cholerae.
Subcellular Localization:
Nucleus.
Sequence:
MNCDTAQPWMMSSYHPSTTSDVFWTTTPSSTSTTPSSDNGIQQYSSISTSSGYAPANSPAKTAEVNQLGGVFVNGRPLPFEMRCKIVELSRQGTRPCDISRQLKISHGCVSKILTRFSENGTIMPGTIGGSRPRVTTPKVVEYIRSLKRSDPGIFAWEIRDRLISADICDRANLPSVSSISRILRNKNGGNSSSSSSSQLRYIRDQLAEQQQQQHLQQHQYMEYNNNELNQISGNLDYQVSSSNTPPSYDSYHFIAN
The following text describes a protein:
Function:
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Sequence:
MDAIHPVSLRNSKRHPLLHSERNLSRRAVSPSISRSFFQHSNGSFPLFQNHRKSLPSAIYKSVDPYVDANPLDPLAAAKASFADFPEQDDSQSSTSPLSSKYHTKKNKQIFVEDSRRGGAASNAAAIAAKKSGYYERTSTRKRSLTVPTPRTSFPHHPRSRRFSLKNAAIATSYHKFKPLSSNSLSSSGMHFSASKQAFNSPLLQTFSPSPSVSPFSNPAVEKLKTSASKQAAEAQSLREFDFFTPTPEPSDKNLEKLKNGASKQASESQSLKNMESLSLARSSPILTSEKLKNGASKQAIESPPFRASEPLPSSNIIPNPAMERLKNGASKLAIESQPFKSAEPLSSAIPLPNPMSEKMRNGASKQAIMAQSSKINPLPPLTASISDPSFEKLKNTASKQAIESQSLMNSGPELLEPSISDPMLEKMKTDAGKQTVESLSLKSSDATIPKPSVSDLGVEKLKNDASKCAVESQSLMINDPSVSSTSFYNPNMEKLKNGAIKQAIEHQALNAAILNKTQLPYFHQSSSELPISASKRAALSQQTESASKSSSNISEMCDSHPPSNFSISASQQASKDRFSEATSSIDLDLSPGRSLSLASSKLSVKEAGARVYNRSVATPVMTPSNPFEISKSASQLASIAQVPVSEPAKTSEVNLKKSLSLASSKLSFQEAGTSLKEKTANVQHSPEVLNDRSLASLSASRHADAISSKSKQHTEIAQPAFNTTGTVLMKTKSNLSDSALSTPQHSDSVLFDITSKAARLASTCAKTDLHRKPRRKHKSFTLENYFGHNAEDESPQSDEVESQTPPSGYSENDIGGTDIYPFALQGAALAAAKDFSRREASLSDSQSAASMDMLPMKKKLSHSSASSTRSIKSLLTNANQKHIHSSINETDDIPTMAAHIVATGQKNKEKAPSFSNDQALDHLLGSAHKRIPSNKTEWSSSSLHIPSHNSFSDIHHRKIAAHAAAITAASEKLTPSIEETSYSSSKAHDASLSAATLVANKDKLIHAPTPQVLAPVLPKVSLPHRHSVSLGQIRGESEVEGDVFYDAPSDKEDLGSSNAPLDVPHGANRSSMDEVNGSKYDYSDGILDGSGQYTDSDMSDDENSLKDSQSSVLSFSAVPTKVLKFKLRDVLGSEYSPSPQLLASSSDVSGSSSAVRAAMKADKIFPAVHENPPPLKTKQSIAKPSPHTLRVPQKKHKHFYHRDDGKYKSGTNLRKSETVDLPQFFIDENRRKLYEGLWAANKGYLLSKSEYSKPNDLICNIVVRELWSRSGAPTSVLAKIYDLVDRHHTGVLGRDEFIVGMFLIDQYLKGRKLPLKVPDSVWLSSKRMGDMLWRLEKLQKKTDNKKPFFKKKKKKRKHLKKFFDFNTTAKVNEGAMTD
The following text describes a protein:
Function:
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Localization:
Nucleus.
Sequence:
MSDWQVKYKSTVKDRGARGILKLREGMLLFVPNDPNSDSKLKVLTPNIKSQKYTKEGSNKPPWLNLTNKQARSHIFEFENYQDMHACRALITKALAKCEEEPNKPAAVLTSAEQLSIADLELRFKVLRENSELQRLHKEFVETKVLTEDEFWATRKKLLGKDSIRKSKQQVGLKSMMVSGIKPSTDGRTNRVTFNLTSEIIFQIFAEKPAVRQAFINYVPSKMTEKDFWTKYFRAEYLYSTKNTAVAAAEAAEDEELAVFLKPDEILAQEARQKIRRVDPTLDMEADQGDDYTHLMDHGIQRDGTMDVVEPQNGQFRRSLLQDLNRHAAVVLEGRNIDVDSEDTRSVAEALARVKQVSKADGETTKDANQERLARMSRVAEMEDLQAPQNFPLAPLSIKDPRDYFESQQGNVVNEPRGAGTLKRNVHEAYGSLKESILEIRTKGLSDPLIKPEVAFEVFRSLTQTISTAKNIIGKNPRESFLDRLPKSTRDEVLHHWTSIQELLKHFWSSYPITTTYLHTKAGKLKDAMSNSYSQLEAMKESVQSELRHQLSLLVRPMQQALDAAFQHYDADLQRRAAKSARGSAGEANGSV
The following text describes a protein:
Function:
May act as a carbohydrate transporter.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MTFLKMKSLSFFFTILLSLSTLFTISNARKFNVGGSGAWVTNPPENYESWSGKNRFLVHDTLYFSYAKGADSVLEVNKADYDACNTKNPIKRVDDGDSEISLDRYGPFYFISGNEDNCKKGQKLNVVVISARIPSTAQSPHAAAPGSSTPGSMTPPGGAHSPKSSSPVSPTTSPPGSTTPPGGAHSPKSSSAVSPATSPPGSMAPKSGSPVSPTTSPPAPPKSTSPVSPSSAPMTSPPAPMAPKSSSTIPPSSAPMTSPPGSMAPKSSSPVSNSPTVSPSLAPGGSTSSSPSDSPSGSAMGPSGDGPSAAGDISTPAGAPGQKKSSANGMTVMSITTVLSLVLTIFLSA
The following text describes a protein:
Function:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSSKKSYLKSGKSSSESLYSQASSYQNEVAGPSVSSIFEPPQLRSLDSDVVIIFKSFQKRDPITRKRALQELLNMKNSDVFENYEFLNAWSVYFPRFAIDEDRSVRQLTFKAMGLISQTLGRKIAPWLRQFMSSWLLGFFDTDRLVSRTARESLLLLFPEEKWDMLYVKFSGIITPFCIEILKYESPETLSDLRFVSVEDSNNKYIRVVCSTISMFRLLVEKLSNDELEKSGVIESLQELLESGLLWDFASAGDSAIKRRVYGLFTALLHHRPDLLEPYCVKFGNESHRMLKNADGLSCIDMLIFLRTTVGQFPLAKTEMLKEHKKRTIQSRLQNLISRKLCSPGTRFYDEFNNLVDALGCDSIIQNLEDFNGFIAAFMEAAEKEQRCFANDVYLHMFDFGKLLYYNCCESTRQFILESNRKNIVNFLRNAWQPHCASTDFIHTMMNTFLNTSKEALVILTDIIDEFFKTYNVTEASFEDLEVTLGLLEAIFLVPYDEEYPHKLLVSFLEIYLNFVFSVLSLEGVGRDRCLLALSRICSFLSTNHVSLDSSHTSLLKFATENLPSLIVMNTSESAFILLRVLLSTLNTENAKHVWSVVLNSILKCPDDNQRVSLLNKLPFILSTKELAHKLDLSPELNQYFQSAVKALTKTDSPDWALIQHIIDSKDILVSDATVKYCFCDIAYFIKSRNFVTNIDALIAMKKIFECFADDLQDLLSEDKSALKTIYILFVETPSDITYAELMEYQNVKRDVLAVLTSATAKNAQLREDIFESAVLFIREWLLVRQRNARDVVDKCIRFLEMFNFSESLSIFAFSSEYWDNFKRVYVPLVASHYFPNTSHLLSWLDLIEMDICTAPLDNHLDTYIRAMSFDLAVLVNSKCNDFPPSYLIFARLVCRVILELGNTSRSRTSMLESFINDFDNYVHSCVRNTSESSVFANLMQKLFDYSSSILDFLKSESVSSSENISMEQIVYAQSLSDFVKVALFNIEYSSDDLETFLQNIGLTKRDNLSKAVLLEMLGDRIHDTKSIERVRFEAANNLAGRLTEANTIQNLIVLTASLPGKAKEKPILPPTRAVVLLQNLFRQVKTDFLGGGSVTEGVLFLAFSCKFISSAPSLPNGLWTEYLDSLRLVLEMSSMQLPGLLSLQFYALRMYSVFLKISEDNEHVQSLLEDSNQVFYECFVQKFFGVTSSPLKNSITMRMCTSLLIKFLRNCPVKLIQKRSYGELCPNVSEGRDVDLQLLALSFLKQKVVSDIEEKTLQLSLNENEEEEVEVPDELLSIIVDHPDDPTEMLRNVDSNESFLRSYLLAWEVAFLFLDRTIYQIKNSITQQIVEMDLLEPLLDFLVELLQLNYTKPVDVSKYSIVSYSLHDYDSAIDRLRSLGTHILYQCLSKMPSVVRASWAGFKNRAFTSVMESFVEKHISPIMVNASLDDVENALQTTNFHSANDTEIKVNRLTREVLFIYRVDEHKLELSIRIPAAYPLRQVRIEGLQRVGVNERQWRAWILASQSMLVSQNGTILDALLLLNKNISLHFEGVEECAICYAVLSMERTLPNKKCATCKHKFHSACLYKWFKSSNASRCPLCRSSFSFA
The following text describes a protein:
Function:
Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G, U/A, U/C or U/T base pair as well as from single-stranded DNA. Specifically recognizes uracil that is flipped out from double-stranded DNA.
Miscellaneous:
MISCELLANEOUS: The 4Fe-4S cluster may have a structural rather than a catalytic role. Does not appear to be essential for enzyme activity.
Sequence:
MTLELLQAQAQNCTACRLMEGRTRVVFGEGNPDAKLMIVGEGPGEEEDKTGRPFVGKAGQLLNRILEAAGIPREEVYITNIVKCRPPQNRAPLPDEAKICTDKWLLKQIELIAPQIIVPLGAVAAEFFLGEKVSITKVRGKWYEWHGIKVFPMFHPAYLLRNPSRAPGSPKHLTWLDIQEVKRALDALPPKERRPVKAVSQEPLF
The following text describes a protein:
Function:
May be involved in 20S pre-rRNA processing.
Sequence:
MEEAFGRVVQHIFSNWTALKLAVEYSESGGNPKEVVNDFINYTTQYCLYESNVDPDGIQEALDDILDQEFDTICEDGSTREIALVLYRFVDLLKQGNTQLFEEEYQKLPIGAMSSVKSIKSPSEEVTEVSEPNTSEPDSEKSSQIPMEEDSEWTEVKSRRKR
The following text describes a protein:
Function:
Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity).
Subcellular Localization:
Cell junction. Cell junction, adherens junction. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell junction, tight junction. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity). Colocalizes with E-cadherin and BCAR1 at or near the cell-cell adherens junctions (By similarity). Localizes to respiratory cilia axoneme (By similarity). Localized to the transition zone of respiratory cilia (By similarity). Localized to the transition zone of photoreceptor-connecting cilia and renal monocilia (By similarity). In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions (By similarity).
Domain:
The SH3 domain mediates the stable interaction with Cas.
Sequence:
GEEEDEEEEEEEESEEGGGEEEESEEEEEEKQENESHHQATSKEYIAVGDFTAQQAGDLTFKKREILLIIEKKPDGWWIAKNAKGNKGLIPRTYVEPYNKEEGQDTSEEEDSEEDVEVGDQTAGGEEVKQRTDSHWSAVQKAISEQINTVDVLTTMGAIPAGFRPSTLFQLLEEGNQFRASYFLQPELTPSQLAFRDLMWDAKTGTIRSRPSRVSFILTLWSCKMIPLPGTSIQVLSRHVRLCIFDGNKVLSNIHTVRATWQSKKPKTWTFSPQVTGILPCLLDGDCFIRSNSSSPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGIPIPAKTYELFLNGGTPYEKGVEVDPSVSRRAYGSVFHQMMTMRRQPQLLVKLRSLNRRSRDLLSLLPETLIGSMCTIHLLIFYRQILGDVLLKDRTSMQSADLISNPVLATFPKLLEQPDMMDALRSSWAEKESTLKRSEKRDKEFLKAMFLLVYHDCVVPLLHSTLLPPFRWAEEETEAARWKVIADFLKQNQENGGALQALLSPDGVHEPFDISEQTYDLLGEIRKNVA
The following text describes a protein:
Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Sequence:
MKSDCMQTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRTLVRKYSCDLCYTPMIVAADFVKSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAARIVCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQDMVKQVRNQVETPGFSVSIKIRIHDDLKRTVDLCQKAEATGVSWITVHGRTAEERHQPVHYDSIKIIKENMSIPVIANGDIRSLKEAENVWRITGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVDIALELGTPYMCFHQHLMYMMEKITSRQEKRVFNALSSTSAIIDYLTDHYGI
The following text describes a protein:
Function:
Binds to the human erythrocyte Duffy blood group determinant (ACKR1).
Miscellaneous:
MISCELLANEOUS: Neutralizing antibodies raised against the protein inhibit the invasion of human red blood cells by parasites.
Subcellular Localization:
Membrane; Single-pass type I membrane protein.
Sequence:
MKGKNRSLFVLLVLLLLHKVNNVLLERTIETLLECKNEYVKGENGYKLAKGHHCVEEDNLERWLQGTNERRSEENIKYKYGVTELKIKYAQMNGKRSSRILKESIYGAHNFGGNSYMEGKDGGDKTGEEKDGEHKTDSKTDNGKGANNLVMLDYETSSNGQPAGTLDNVLEFVTGHEGNSRKNSSNGGNPYDIDHKKTISSAIINHAFLQNTVMKNCNYKRKRRERDWDCNTKKDVCIPDRRYQLCMKELTNLVNNTDTNFHRDITFRKLYLKRKLIYDAAVEGDLLLKLNNYRYNKDFCKDIRWSLGDFGDIIMGTDMEGIGYSKVVENNLRSIFGTDEKAQQRRKQWWNESKAQIWTAMMYSVKKRLKGNFIWICKLNVAVNIEPQIYRWIREWGRDYVSELPTEVQKLKEKCDGKINYTDKKVCKVPPCQNACKSYDQWITRKKNQWDVLSNKFISVKNAEKVQTAGIVTPYDILKQELDEFNEVAFENEINKRDGAYIELCVCSVEEAKKNTQEVVTNVDNAAKSQATNSNPISQPVDSSKAEKVPGDSTHGNVNSGQDSSTTGKAVTGDGQNGNQTPAESDVQRSDIAESVSAKNVDPQKSVSKRSDDTASVTGIAEAGKENLGASNSRPSESTVEANSPGDDTVNSASIPVVSGENPLVTPYNGLRHSKDNSDSDGPAESMANPDSNSKGETGKGQDNDMAKATKDSSNSSDGTSSATGDTTDAVDREINKGVPEDRDKTVGSKDGGGEDNSANKDAATVVGEDRIRENSAGGSTNDRSKNDTEKNGASTPDSKQSEDATALSKTESLESTESGDRTTNDTTNSLENKNGGKEKDLQKHDFKSNDTPNEEPNSDQTTDAEGHDRDSIKNDKAERRKHMNKDTFTKNTNSHHLNSNNNLSNGKLDIKEYKYRDVKATREDIILMSSVRKCNNNISLEYCNSVEDKISSNTCSREKSKNLCCSISDFCLNYFDVYSYEYLSCMKKEFEDPSYKCFTKGGFKDKTYFAAAGALLILLLLIASRKMIKNDSEEATFNEFEEYCDNIHRIPLMPNNIEHMQPSTPLDYS
The following text describes a protein:
Function:
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MEPSDIPESTTFYEYDPQSFLCEKRTFVFATVSTTILYCLVFFLSLVGNSLVLWVLVKYESLESLTNVFILNLCLSDLVFSCLLPVWILGYHWGWVLGDLLCKLLNMVFSISLYSSISFLTIMTIHRYLSVVSPISSLRVHTLQRRVLVTAAVWAASILSSIPDAIFHKVFPSGCDYSELEGFLASVYQHNVIFLLSVGVILFCYVEILRTLFRSRSKRRHRTVRLIFTIVAAYFLSWAPYNLILFLQTLLKLGVIQSCEVSQQLDYALLICRNVAFSHCCFNPVLYVFVGVKFRRHLKSLLRRFWLCRQQAPSLPPSPHPPGAFTYEGISFY
The following text describes a protein:
Function:
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MGKNKLTVPKVSLYNPVELKKVLDLGLEEILKTQLKYDIDYWYSNTIIVCSVICSFLGALAWWYPKPWLESYWHIVAIIIIYIIVDGYLTYIMWFKHSGFAVAIKKPKIEFYSAMISYTPYFQIIMRKDKKEYSIEIEVNKVFDSEGKLLLPLYQGYVEKLINFE
The following text describes a protein:
Function:
Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Subcellular Localization:
Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence:
MTQSNSDSSSTGDVPNINTSLIPSISKPVYSRIPIPGHLSNDQSTPIEDIKIIDKQSIDYIIRSGLAGGLAGSCAKTLVAPLDRIKILFQTSNPEFIKYRGTFGGFIDAGKRIWKTDGVMGLYQGNSVTLLRIFPYAAIKFVAYEQIRTFLIPNDSYETAARRFMAGSLSGLASVFFTYPLDLVRVRLAFETRNLSHSQIHHHHKEFMAHRRGRIFSTVSLIYNENPPIKTTDPSWLKLMRKSFPSPINHLANFYRGFAPTILGMIPYAGVSFYTHDLLHDILRSKWLAKYTVQSTNHQNVVVKKKGKSSRESRAPLKAYAQLFAGGLAGLCSQTAAYPFEVIRRRMQVGGAINQGQFLSFKNTAKLIYRENGLQGFFVGLSIGYMKVVPMVACSFFVYERMKKFLGI