lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.
Sequence:
MRIIYVFIIHTEIPGGCSEEGPGKNVSEEARVTDVKEIPDAVLPDRTDQDNSASDLSEDLGPAFIKEENAETEPDAEDFTPNPSKDPSVVRIKEESLDIDHDSTSNTSEDQAGPTTAKRGTVEENPENLSPLGDAQNHFRIITVSDTGAGKHWSDNEVRALIHVWSDESIRQMLEGATRNKEIFEEIARRLLWFGIDRDWKQCRTKYKNLKYEYRVGQKGSDLGSPRRKMRFYEEIDGILRPRAPRATSWRSGCPKPAESPKDPGLSPGTVSVKRRAYGAESAPVPLKRRTFENNADQLPRRVTERSSDGFYRQEIPSTVQTRLPGNQTVPQVLPAGPMDSAAELKRGEKLYEGKTKEVYLLPHLPGNVLLQSKDQITAGNAARKNHLEGKAAISNKITCCIFQLLQEAGIKTAFTKKHGDTALVALQCEMIPIEWVCRRVATGSFLKRNPGVQEGYRFYPPKVELFFKDDANNDPQWSEEQLIASKLTFAGLTIGQTEVDIMSHATQAIFEILEKSWLPQDCTLVDMKIEFGVSVSTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSDSRGRVVVLMGSTSDLAHCEKIRKACGHFGIPCQLRVTSAHKGPDETLRIKAEYEGDGVPTVFVAVAGRSNGLGPVMAGNTAYPVVNCPPLTADWGAQDVWSSLRLPSGLGCPTILAPEGAAQFAAQVLGLNNHLVWAKLRASLLNTWIALKKADRDLRT
The following text describes a protein:
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular Localization:
Secreted.
Domain:
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues; The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
Sequence:
MFLLKCLPLVALIAAAFSANPGVKIRLTQKGLEYGKQLGMASLLEKLKTAQIPDFSGKERVSPIGKVQYSLTNIHVVNLGLPQSSINLVPGSGVQLSISNAFISLRGNWRVKYLRFIKDSGSLDVNVNGLSISQTIAIKSDATGKPEASSAACSASVSSAKVKFHGGASWLYNLFSKFIDKALRKALEKQMCPLVAKSIADLNPRLKTLNVLAKVDKYAEIEYSMVSSPQISQPAIDLNLKGEFYNIGRHQEAPFPAPAFSLPAQSSNMIYIALSSFTPNSAGFVYNNAGVLSMYVTDDMIPRSSPIRLSTSTFGFFIPQIAQRFPGLMMKMLVKADKNPVVKFQPNVMTVDATATATAYAIQPNGTLSPLFVLNVDSSVSSQMSVSDLKLASRITLNKMSLSLGTSYVGDFKVNSLDNILQVILKLVVIPTVNVQLSKGYPLPALGKMKLVNTQLQIMQDYLMIGTDVQFTG
The following text describes a protein:
Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MDSSTAHSPVFLVFPPEITASEYESTELSATTFSTQSPLQKLFARKMKILGTIQILFGIMTFSFGVIFLFTLLKPYPRFPFIFLSGYPFWGSVLFINSGAFLIAVKRKTTETLIILSRIMNFLSALGAIAGIILLTFGFILDQNYICGYSHQNSQCKAVTVLFLGILITLMTFSIIELFISLPFSILGCHSEDCDCEQCC
The following text describes a protein:
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Sequence:
MSGYRSQISKSKDPSGLLISVIRTLSTSDDVEDRETEKGRLEEAYEKCDHDLDEKIEQHFTELTTAIRTYQSITERITSSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVDSLEGPLLQVEGLSDLRLELHSKKLNMHSVLIDELHRHLYIKSTSRVGQWNKDKMRSSLLVKDSPVPLLDVTNLSTPRKFLDGSHFGTPTCSSVKELSLEDIKEDPDSDPEENSKIFMGILIKGLAKLKKIPETVKAIKERLEQELKQIVKRSTTQVADNGYQRGENNTQENQPRLLLELLELLFDKFNAVATAHSVVLGHLQQTVLSPTSQHDGDIKLYDMPEVWVKIQTVLQILLTEYLDMKNTKASSEASTQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSKSGELQGGPDDNLIGGGTRFVCKPGARNITIIFHPLLSMNLLANAQLEGAGNLVGVLAVRPEASTTEQKMAPRFIQEIEHAMGLGPAKQCPLREFLTMYIKNIFLHQVLAEINKEIEGVTKVSDPLKILASADTMKTLGVQRPLLQSTVIVEKTVQDLMNLMRDLSAYSDQFLNMVCVKLQEYKDTCSAAFRTVVQSEEKMVISASWAKDDDITRLLKSLPNWLNMAQPKQLRPKREEEEDFVRAAFAKESEVLIGNLGDKLIPQAEIMGDVSDLKALANLHESLEWLAGRLKAAIASFPSSQTMSPGSDSIASVDIPVVSELILQTLSELAKSFQDMSDRCLLVLHLEVRVHCFHYLIPLAKQGNYAIVANVESMDYDPLIVRLNKDISGIEEAMGASLQQHKFQYIFEGLGHLISCILINGAQYFKRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMMYNTADELLNLVVDQGVKYTELEYINALSLLHRSQTGVGDQTTQNMRLQRLKEIICEQAAIKQATKDKKITTV
The following text describes a protein:
Function:
May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.
Subcellular Localization:
Nucleus.
Sequence:
MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTEASVPAKSGPVVQTMYKACPCGPCQRARCQERSNQIRSRPLARSSPE
The following text describes a protein:
Function:
Probable glycylase which modifies tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of tubulin.
Subcellular Localization:
Cytoplasm, cytoskeleton, cilium basal body.
Sequence:
MSDRIYHSYVNNFYQKAKSPKNTQLIKQIQRSNPTSPKKNLQIYKNINPFNHENCQRIIEENAIRFSDKKTVQLGTVYGCNILLTTKNSQPKVFEKLIQLSDNSNFRQVTLLKSISPVSVVKAKDFLNDSISNRSRSAQKMYSDKDKFQVGNNKSSLRSLIYFPLANIKDQISEESKSKRNKIKVIKDMPIQLDNSFQTINHQINSPNNNIVGDQSHVILHNIFKKRQQAEEGLQIQEEPQNYIKNKLELQERKMYLENQNPKSLSPIKIHFNEKSMPFKNKIQKKITYNEQSSIQQTITLIKKKILGPPSLYSRLKKNSEQFKNIENLIKNKAKESHEQNMQEYLKRIGCTDKNKKVFCINSQDQFVQEVLIELGWIENKLFKSDLFHLKWIYTDINKDYENLKEGQFYNHFQNNQELTNKGRLLRNIKLYLVSYPHLQKYFPIQFDVIYKQQKEEFLNEFQKFEIFRKFKDVIQIIKNDLTQELINQLTQIYHTKFIKKEEEEELQYGLITYFRQNQQFKQYIEYINQVNKDIINLLSKIPNPNINEMLIKYLNDLSILQVDKLECDQEQGDKNIQAQIINLSISIELDNILEQIYPYTNFCNFWIIKPCGSSKGQGLQIMSDDNQIVNYTTQLQARLVQKYIERIYICKSQEYPQLYNKKFDLRLWVLVKSFNPLTVYYYKHAYLRVCSSEYDLSDTRNIFSHFTNYSINRNKFIQNKNVEDSAISLKLLKHIIKKEHGISYQKKIQPQINEIIIHSLKSVQKKIKQNNSCFEIYGFDIIFDEQFNPYLLEVNLSPACSKRNEFISKLQKEMFISTLNILFNTEYYQIQNWKKIKIQDQIQKVINESTHTQLQEEVILNSNNFQSEDSEERFISAAITIQKWYRQIKLMKNENQKI
The following text describes a protein:
Function:
During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival.
Subcellular Localization:
Presynaptic cell membrane. Early endosome. Lipid droplet. Note=Colocalizes with Eps-15 at presynaptic cell membrane.
Sequence:
MAEEESEFLEAYAGIRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAEWNDACALIQKLKSAETELRYRLKVLRSQKQSIDDSAVEATEESRAEMDTKRPPLLAENPSTQYGIANASGAPKTYRELAAGLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGKWKYLSGIYFIQCSMPNEGTAGIWLYPLVPSITNCYQTEYGAFIFPDMECQQPGNAFGLMLTKEGQTSRTEDELEDLQQFFLDLLEAVLAGTVVQLKSPTSQRAGLASDTVSGSEQVSRHIVSAADFIASNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAAAGMTGWIAGKVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVSTVFDGLETSAKILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKMVKRTGEAVVSDYKRDLRKSESHYINAGSLYPDLRALKE
The following text describes a protein:
Function:
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
Subcellular Localization:
Cytoplasm.
Sequence:
MGKAKNKKKFLKNRKQVLVPGTLFVHSRKGFGFVSPDQPELYPFDIFISASDLKGALDGDHVLVALPFSLRGGEKRKGVIHKVLSRGKTVLVGTIVSLINPTLAMVYVNTIGPEHPLKAELLPKRTYKLGDRLLLKTPVWKENYPSREPPPLAMLEFIGNISNAKTDFPVIKAEFSITEEFPDAVVQEASQFLQKHVTQALHSRKDLRDLLCFTIDSSSAKDFDDAVSLTYDHEGNYILGVHIADVSHYVTPNSALDREAAKRCNSIYFPGKVIPMLPSALSDNLCSLKPNVDRLAVSVFMTFSKEGFLSDYRILRSVIRSKYRMTYDEVDEIIEKKQTHPISKTILKMAELSRIFSDIREQRGCTRLVLPSFTMSLDNLQEPVALIENKQTAAHKLIEEFMLKANEVIAYHISHQGITMPFRTHEPPNEESLLVFQETAKAMGFTITQTPAQEPDYQYLLQETTAGHPLEPILHSQFVRSMKTASYSTENKGHYGLCLDYYTHFTSPIRRYVDLIVHRLLFHPLSVEEEHLEQIVRACSSQERIAAKAEGAFVNIKKARFLKKFIEEQPATLYKAFIITASPEGISFVLPEFCHEGFIPAAKLPQAYVLQTKIGLEELPEHLRPGAVISVQLASVTLLTQSIEWTLVEATTKAKAKRTSKKKKTESVTTKEKKKSPAKKKKGATKTKKGSGKN
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MPNGKQQHEVTESSSPPEIPHITANMIPLSNIIKYYTQEAYKQLTTAIENLSMNVNEESDIKRKKYFLNVIINLRQDFIKVYTLIKWASISKDVSKFIDLLNWFRIQEFHFENLIFQLNALTGYNAAKLPNSDIITALEVLYHGRPKLPSYNYIKSDNLSPQKILETLNDLNLVLMTRFALMDNIPKRFDYEIKDGRAYIRVSNEFEVSITVGNDLIIDNPEEYYKSPFYFIDFKFLFGANPESGLITFNDDKISTKLPTSSHKKLEKLVNQTLLTRGLQGLYELLHKYSNSFKIYLLAKQFQTLLINSRWRGNFQINYQTNKSLIVINYWSQHYLSRNWKSFIELGIDSHSNLNYRWFKNGQYCFGDQGNNELDKIFHLQRRNSNNGVTTSSNTISTSAMIAGIRRSTELSNETAIVDDNDNDNDDTNNTGETENEDLNVDLILNVVVNQHAKSIMSEIYSQLLTRFSETDVSMVSPHQLLLQISPKKSTVFAINPLTGFFYFIDPTPIQTYITKKINSPPPTLSQVSIKQSFIPESDMISYVIDQIIQLRLEVFNKEVNTKLATTAWINNGIIKLSDHELSKLTQFLIQNEEQEGDDNEEDSSTNTRLDSVLQSFKVQFYRRKNWPSSWFLINMISGVTTKSFWWVARIKSISGDWKIQWAQIIKFHGDNAKQELSPNESKVFDKPKRTVDCSIESEQLNFEFFKTLSTLSSNLILDHMILEELQVRSIKFIKLDWETIDDNKIFSKFKQNHDISLKRKNSHNINIDVNVDVADNTSTTTNTKYIRAPKLKYESMFLIYNDKLLPIYNSATILFLKIELVESNKMYLKLFGNLRNLQIKNTSEDIQKLHLNIDEANQYFEIDNTVDLSTVINEPKTLLLNLIFNTLNKLNSLIKILDQLNKSNVTVLDNSMDNITINIKDKYNDNNDKLIIIKLPEQATDSIQLLMKNGSTTTTDEIDLRNNNILEFELILKFLNQYLRESKSNNHNRQQISIIKIIQYLTEINPILQSTKAINQQLAELKRINSTNNNNNNAKRRSILKLSNGLYKLYFNLNIISLTHLQLVFFMNSNTGSNLKKIQRDKIMINLSLIKFDRFSKPNGNFQDSTNGHLIKISFKDSLINENLKFKNLFEIIFKNINELLITKSKQIKSLNQTENQQQQQPLKQEDNSDSAIIKKESQSIEDDLLDFGEYDNDIKPQQQEPQQNEKENSKTTSKENETVRPDDILIKLNYDYLLSMNNLQLMINEITKSCFQYLQQQQE
The following text describes a protein:
Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (By similarity).
Subcellular Localization:
Cytoplasmic vesicle lumen.
Sequence:
MHLPSLSVALALVSSSLALPQAVLPENDVSSRAAAVKEAFSHAWDGYMKYAFPHDELLPVSNSYGDSRNGWGASAVDALSTAIVMRNATIVSQILDHIAKIDYSKTSDMVSLFETTIRYLGGMLSGYDLLKGPAADLVEDRTKVDMLLQQSKNLGDVLKFAFDTPSGVPYNNINITSHGNDGATTNGLAVTGTLVLEWTRLSDLTGDQEYAKLSQRAESYLLAPQPSSGEPFPGLVGSAISIQTGQFTNGFVSWNGGSDSFYEYLMKMYVYDPKRFATYKDRWVAAAESSIDHLASNPASRPDLTFLATYNKGSLGLSSQHLACFDGGSYLLGGTVLDRADLIDFGLKLVDGCAETYHQTLTGIGPESFGWDEKSVPADQKELYERAGFYVQSGAYILRPEVIESFYYAYRVTGKKQYRDWVWNAFENINKYCRTESGFAGLTNVNAVNGGGRYDNQESFLFAEVMKYAYLTHAPGMSSMPAAAEDKANKSRG
The following text describes a protein:
Function:
Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).
Subcellular Localization:
Nucleus.
Sequence:
MSTDIFSICAKCLGDESRIKMIKQVNGDECRQCTRPYTIYRWGNRKQGNKTIICITCARARHCCQSCLLDITYGIPTDLRDTALEMAGLEPLTKSANPTNREVKAIMADKLETKFKEQQERSNDILSKLAEKLNKPEEKKTEVAIDVAKLAKKLPFGNSLDVQKYPDMTTFFVFGFSSDFPQAIFSRYAEQYGKVESVVFSSVSGCGFIRFEKVSSAVGFAKSIAENGLNKNKSIAGLLILENTPMRVCFGKQKPLPRTAADQRKLNTVVTKVMKQLASKSKVGVVVKTKPNVYKALSEDYEE
The following text describes a protein:
Function:
Catalyzes the formation of N-benzoylanthranilate, in the course of methoxydianthramide B, a phytoalexin. Phytoalexins are produced in response to infection by parasites, and are essential for the expression of disease resistance.
Sequence:
MDVKVKECTMVCPANETPRHNLWLSTIDLVGRTPYAHNQIMYIYRQNEDQNVSKYFNAEILKESLSRVLVPFYPVAGRLKKNEKNGRIEIDCNAAGALFVDVETWHSLDEFGDFKSSNEFRKLVLHPWDYSGGLSSFPLLLARVTRFKCGGVCIVFSIHHQATDGIAFAYLINSWSRLARGLDLDVHPFHDRVIYLGPRHPPQIKFRHLEYEPPLPPISPKGFAGETSTTKECLFKLSKPQINALNLQANSPSEEKEKHHSYKLSNYEVLAAHVWRTACKARDLANDQLVKLYIPTDGRSRLKDPTPLPQGYVGNVIFYTACIAKTRDITCKPLWYAAGKVHEALKNVENVEYLRSAVDYLESQPDLTPIVRGAHTVTCPNLTINSFGRLPFYEADFGWGKPEFAGHSKLRYEGQTIIVPSPIRDGSYSVNINLFAVHMPLFRKYFYDVGNLPNKL
The following text describes a protein:
Function:
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
Sequence:
MADDHSDSSLTSIDDERTDNTENLCENPTRDILTEGFFRLFKPVIDDLENNIRGASKTQSELRQQLEELSGEMKNLNFENDPVLHEYFKRMVRVKQKVVVIMNILQGAQERLVTLCQQQELQTPVPGT
The following text describes a protein:
Function:
May be involved in the regulation of cell migration.
Subcellular Localization:
Cytoplasm.
Sequence:
MSKVARSSSESDVQLWETEEDDMTEGDLGYGLGRKPGGIYEIEFSHRSRKRSDGKNFSPPPFPRKGEERNEASFQYSKHKSQQDTFPQVSRISNYRRQSSTVDSNSELSNEELRQCLNETLEEVEMLKTELEASQRQLRGKEEALKILQSMAILGKATSHTQAVLQKTMEQNRSLEKEINALQWEIEFDHNRFKNIEESWIQKYDRLNCENAVLKENLKVKTEEIKMLKSDNAVLNQRYLEALAMLDIKQQKMAQENMCCDKSGFAEASGLELAVLGACLCHGPGGNPCSCARMAASTRKLLLQLKQELEILQKSKEEAYVMADAFRIAFEQQLMRKNDQALQLTQMDKMHKKATKWMNWKHLKEDGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEEALAHQRKVSYMLARALEDKDTASNENKEKNPIKENFPFNNPWRKTSEFSVLGDPIHSSVCILNSVGCICSIQHSQIDPNYRTLKRSHSLPSSIIF
The following text describes a protein:
Function:
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MRINVCFLNFFFFFFFFFVLFLNTNECFQQEEKLKKLKKLLNKKIKFDINEKHKNGYKNTRYSFIYIHELTLIDYVDYVLNKSSEYDCILFYINVESSNNVSKLDRKTLILLEIFNEVARQIIFNNFVLYNESEDVLLLNKEIRNEDIETKYVNNNNNNNNNIYETKDHNDKHKKNDFLLLKPVFFFYINFNKSHMNPIKHVHMIYNLPEFVYVHDKTFDNIDYQLIIDTKYMLEYYIKDIKKIDYNHTEINNKMLETYFKEFIYLHNKGNWNKINEKNPEEKEKVFITLLIIFLFLFLYLFVLILQKCNFLIFLCSYFLYFICLSGLFHCLINKSELYNTSKNLDSFFHKYIYRSTNSQYICEGFIFSFLILFITLLFFILLKFSSNIKEEDTSLLLHKSKKINILSLCILCVIFMSLKFIQDINLYKIYFSTYYFFPPLKFFRK
The following text describes a protein:
Function:
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Sequence:
MITFPNAKINLGLSITEKRPDGYHNLETVFYPVALEDALEIRTSPEADKKFSLHQYGMEISGNPEDNLVVKAYLLLDKEFHLCPIEIHLYKHIPSGAGLGGGSSDAAFMLKLLNEHFQLNLSEDQLEIYAATLGADCAFFIRNAPTFAEGVGNIFSPIPLSLKGYQILIIKPDVFVSTREAFANIHPHHPEYSIKEAIKRPVNEWKEILINDFEDSVFPQHPVIGEIKAELYRQGAVYASMSGSGSSVYGLFEPEGTLPETDWGTNVFCFKGRL
The following text describes a protein:
Function:
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).
Subcellular Localization:
Cytoplasm.
Sequence:
MSDVESADNNVVVEEKAVFDNVTAIQKVIKNAHVHDGLKIGIREVIKSIESQEAKVCFLSDVCSEPAYKKLITTLCAEKNIPLFMVQNDSKDLGHWAGLFKLDNEGNARKIIGASSVAVVDFGEDSAEKDFLLSQNQTVTA
The following text describes a protein:
Function:
Plays a role in mechanosensory transduction (touch sensitivity), touch receptor neuron development and synapse formation. Regulates expression of the protein snb-1 and the distribution of synaptic vesicles at synapses to promote synaptic transmission at the neuromuscular junctions of GABAergic motor neurons.
Subcellular Localization:
Perikaryon.
Sequence:
MTNAQPTELISLPSELLCHLFTYLPQRQLITEIPLVCRRFNTILNDDKFWSRRIRTEQKVRLPDCELKHPEYEPKKSFYAMHRQRDRWRAWETQTVITAPGHSATVDSVMLFENNNKQFCLSGSRDRTIRLWSIENARNGEDTEQNPWTVAKDDTAHSGWIWNMAQESTSTNFYTTSWDSTVKSWHITDNGALQNLNSVNVGSAAQCISCSGNENEVVCTTFAKRVAVIDSRTFQVVADHKLHKRAVIALAVQGDKIFTSGEDRLMMMVDRRNFSKPVLFEYSPTAYKSCLSLQCNQLLTSTSDGKVKLYDANNFNVLQTYSVGSYTRQSFLEHGAHLIMARSLKRNYTFSIYSPGTRSQQWCASHELAAEPAKFDYSPSSRTLAIGNGDSSILFCLPASAPDQEN
The following text describes a protein:
Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular Localization:
Chromosome, centromere. Nucleus.
Sequence:
MAGKIKIPDECSHKTYSVCESTADSRSRVEEDGESDGPAVFMCGKCKLPIGDSLSWAGSDDENNQIMLKRITDNIVVGKEPFVSGTRKELGCLVVNLTCRGCCSELGVMYISTPKKLDCKRSLFCFNVENIESYVVGSPGQQMPELDREDKPVTLEYQDTVHQQMTEITSLAVIIGQRLLEIENNLQCSSEK
The following text describes a protein:
Function:
Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.
Sequence:
MDLDKFGSKFYVSPSKDALKKKYVGISIYEIPTPAFVVDQKVVKNNCDEMLKSIEATGALFRPHVKTHKCIEAMDLQLQGRVNAVVVSTIREAIAVVASGKVDDILYGLPVCRSRLEELYELSKNVKSVRLLIDNLAHIDILKQFAQKHSIKRPFSVFIKIDMGTSRAGLQVGSPELQDLIDTTLNASGIINLFGFYCHAGHSYGASSIEEARNYLLDEIRAANVAAEYVHKKNRSTPLVLSVGATPTAHATKAWIADSVPKLYGRLEIHTGNYAFCDLQQAATGCVSVSNIACSVMAEVISTYPNRKGAPGEALVNAGVISLSRENGRIPGFGNVITEGLENWYVDRLSQEHGILRSSNSKDVLPRIGQLVRIVPQHACITANAFTWYFVTDGGDIITDIWVPWRGW
The following text describes a protein:
Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).
Subcellular Localization:
Cytoplasm.
Sequence:
MEPPMEQSGGEQEPGAVRLLDLPWEDVLLPHVLNWVPLRQLLRLQRVSRAFRALVQLHLARLRRFDAAQVGPQIPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVALAGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDTAVQELARNCPQLEHLDLTGCLRVGSDGVRTLAEYCPALRSLRVRHCHHVAEPSLSRLRKRGVDIDVEPPLHQALVLLQDMAGFAPFVNLQV
The following text describes a protein:
Function:
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Sequence:
MQRIRLGYAGPQKKWESIKWNEFITYAGERGMDVIYIDLDKDLEPQGPFDIILHKVTYMMHSPIVDQNPLIKNLITYIRNHPEVIVLDNLEAVGITLDRELLNNAIESIKWPEGVDIRVPHADMLLQSDLESIKKVTSKLRFPLLSKPKVGSEIVGATKETAHMLRLATSPESLVGVATPTLLQEYINHGGVVYKIYTIGDHLEVTARPSTRNVESGEDISIDFHSERPDDPNGVWIHKDGLDKIQMPIEDFKKLSKAIRTSMKMELIGFDILIDEKGAYWIVDLNFFPGYKMIPNLWELFYNFFMSLLKK
The following text describes a protein:
Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Resistance to the antibiotics salinamide A, salinamide B, rifampicin, streptolydigin, CBR703, myxopyronin, and lipiarmycin can result from mutations in this protein; Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNAP. It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis.
Sequence:
MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSIKLSNVKSVVNSSGKLVITSRNTELKLIDEFGRTKESYKVPYGAVLAKGDGEQVAGGETVANWDPHTMPVITEVSGFVRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKIVDAQGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQESGGTKDITGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVISDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANRELEANGKVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAGEAPAAPQVTAEDASASLAELLNAGLGGSDNE
The following text describes a protein:
Function:
Has no transcriptional activation activity.
Sequence:
MSGRNRIHRDIRDSYHDHRDLPPERPFLRGPPLLQPPPPSLLEDLQIQEGEIRRQDAEIRRLLSDNHGLADDRMVLERELVAAKEELHRMNLMISDLRAEQDLQLREFSEKRHKLEGDVRAMESYKKEASQLRGEVQKLDEIKRELSGNVQLLRKDLAKLQSDNKQIPGMRAEVKDLQKELMHARDAIEYEKKEKFELMEQRQTMEKNMVSMAREVEKLRAELATVDSRPWGFGGSYGMNYNNMDGTFRGSYGENDTYLGSSERSQYYSHGSGSQKKPRLDRH
The following text describes a protein:
Function:
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Sequence:
MATKLNVNIRTLLANCEELAKSEQNFWRLQKFIKSLDTMLAELEAMGDPQSVKRIPGYLERLQALKISTGYADVPGSTTKTPSQSSAVSETGENALKEIRQLQNSKYHNELRKELLQDSDALRRRRGADESSSSSGSANVQETSGENMNQAAKYYTNAQEKITEHMLSLTRNLKEQTETANRIIRRDTEVVSRSAGMADRNINSLGKEAEKLEQHSKKAYKCWLWLMIAFVIATFIGMVLFMKIMKKKKS
The following text describes a protein:
Function:
Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3). Involved in regulation of flowering time. Required for the expression of the flowering repressors and MAD-box genes FLC, AGL27/FLM and AGL31/MAF2. Required for histone H3 trimethylation on 'Lys-4' H3K4me3 at the FLC and AGL27/FLM loci. Involved in the control of seed dormancy and germination.
Subcellular Localization:
Nucleus.
Sequence:
MASYRPPYPPLPQPPSQNSLAPPPPPPSLPPPVPPPPPSHQPYSYPPPPPPPPHAYYQQGPHYPQFNQLQAPPPPPPPSAPPPLVPDPPRHQGPNDHEKGASKQVGRRERAKPDPSKHHHRSHLPHSKKIETEEERRLRKKRELEKQRQDEKHRQQMKNSHKSQMPKGHTEEKKPTPLLTTDRVENRLKKPTTFICKLKFRNELPDPSAQLKLMTIKRDKDQFTKYTITSLEKLWKPKIFVEPDLGIPLDLLDLSVYNPPKVKAPLAPEDEELLRDDDAVTPIKKDGIRRKERPTDKGMSWLVKTQYISSINNESARQSLTEKQAKELREMKGGINILHNLNNRERQIKDIEASFEACKSRPVHATNKNLQPVEVLPLLPYFDRYDEQFVVANFDGAPIADSEFFGKLDPSIRDAHESRAILKSYVVAGSDTANPEKFLAYMVPSLDELSKDIHDENEEISYTWVREYLWDVQPNANDPGTYLVSFDNGTASYLPLPMRLNLRKKRAREGRSSDEIEHFPVPSRVTVRRRSTVSVIEHKDSGVYSSRVGASSSKMRRLEDEGGLGRSWKHEPEQDANQYSDGNEDDYSE