lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular Localization:
Cytoplasm.
Sequence:
MRPLMLQGHERSITQIKYNREGDLLFSCSKDQKPNVWYSLNGERLGTYDGHQGAVWCLDVDWESRKLITGAGDMTAKIWDVEYGTVIASIPTKSSVRTSNFSFSGNQAAYSTDKAMGQSCELFLIDVRNADSSLSEQEPTLRIPMTESKITSMLWGPLDETIITGHDNGNIAIWDIRKGQKVVDSGTDHSAGINDMQLSKDGTMFVTASKDTTAKLFDSESLMCLKTYKTERPVNSAAISPIMDHVVLGGGQDAMEVTTTSTKAGKFDSRFFHLIYEEEFARLKGHFGPINSLAFHPDGKSYASGGEDGFVRVQTFDSTYFENIFE
The following text describes a protein:
Function:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.
Subcellular Localization:
Endoplasmic reticulum membrane; Single-pass membrane protein.
Sequence:
MESCWLTMESYQAALVVCIVSGLILAVAGYGNVRRLACEFLLKPPKRFRDDICEALLRGPENDQKPVLVDFGWRHGAVRRQMLLASAKASAYSNERHGSKIHISPDDIARGRSFADALDVHRRSGRILFGFFHPFCNAGGGGEKVLWKAVETTLKQSLNNIVVVYTGDCDTTGARILSNVEHRFGSQLDSERIVFIFLRHRKWVESRTWPRMTLLGQALGSIVLSIEAALCCPPDVWCDTMGYPFGYPFVSWLCRIPIITYTHYPVVSIDMLDKLRMMPEFRNSPTLWAKFLYWRIFMRCYTFAGSFVDLAVTNSTWTYNHINAIWSRTGNVSIIYPPCSTENLVIENAHDMWDRKHQAVVIAQFRPEKRHALILRSFSNFVKKTGSNMKLLMLGSTRGQEDRDYVKKLEQLAYSELAIPKESLEFITDCKYEKMKKYLQESSFGINAMWNEHFGIAVVEYAASGLITLAHASAGPLLDIIVPWDIEGDKQLERGSDKNRTGFFFKDRSDPDFCKITAEFPTLEELFVRADQLTDEERLAISQRAKRCVLHKFSDLKFSEDWAQVVDRTIQLLHTLRNDKVE
The following text describes a protein:
Function:
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Subcellular Localization:
Nucleus.
Sequence:
MAAQSTVDRVRAASIVALSRLPPQGTKVCYFARGHAEQWPGTAEPEGHGVPCTVASINYFTDGDEPCARISLQPQPAADDPPAADDHNPAPPPGRFLFFAKTIQESDKQRCYLGIPKACEAVFLPFQAGQNEQQLKIQDISGHSWDMVRKNEGTKRLLKGQWKKFVEHKGVKVKDTILFVSCPPDGEILVDLRLAAPHNIAWGVEEVAEASQLAIQGNAFTVTYYPGRGVDPFIVPRAVVEAAAGTKWEVDMPVRLRPKDEVVHLQEQEQGSAAGVTKTGTIAAVNPGTTWRNLQVDWDASTSSTPAAAINMWQVEPQGTHDAKRRRISHTVPPVAST
The following text describes a protein:
Function:
Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
Sequence:
MTTVSDLIDLFETEAAADHPPDETPDVGVIMGSDSDLDVMAGAHDALTDLGFTELTDYDDPPTGYTFESWVVSAHRTPTLMDAYARTAAARGLDVIIAGAGGKSADLPNMTASLAYPIPVVGVPVQEKSVPSVIGMPTGAPITAVDAGKSYNAGLAAAQFLATDDPTLADRLRDLQAARQEGVADVSARLHSQGTDSLRSPQN
The following text describes a protein:
Function:
Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells.
Subcellular Localization:
Host nucleus matrix. Note=Associated with the nuclear matrix.
Sequence:
MPTFYLALHGGQTYHLIVDTDSLGNPSLSVIPSNPYQEQLSDTPLIPLTIFVGENTGVPPPLPPPPPPPPPPPPPPPPPPPPPPPPPPSPPPPPPPPPPPQRRDAWTQEPSPLDRDPLGYDVGHGPLASAMRMLWMANYIVRQSRGDRGLILPQGPQTAPQARLVQPHVPPLRPTAPTILSPLSQPRLTPPQPLMMPPRPTPPTPLPPATLTVPPRPTRPTTLPPTPLLTVLQRPTELQPTPSPPRMHLPVLHVPDQSMHPLTHQSTPNDPDSPEPRSPTVFYNIPPMPLPPSQLPPPAAPAQPPPGVINDQQLHHLPSGPPWWPPICDPPQPSKTQGQSRGQSRGRGRGRGRGRGKGKSRDKQRKPGGPWRPEPNTSSPSMPELSPVLGLHQGQGAGDSPTPGPSNAAPVCRNSHTATPNVSPIHEPESHNSPEAPILFPDDWYPPSIDPADLDESWDYIFETTESPSSDEDYVEGPSKRPRPSIQ
The following text describes a protein:
Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence:
MTKATETGLTIFALSAIYFALITGVIPTPAKIHDEILPYLPWWGLVTFGSYALSTLGWGIVTFKDKEHKYKELKIQIEEAKDFYKTKGIDLD
The following text describes a protein:
Function:
Plays a role in determining ER morphology.
Subcellular Localization:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain:
The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
Sequence:
MGSWFSRRKPVSEELESLSTQMKEFRREIESMNKTRRNALWYLSLLIFVVSSSSVGYIFTTIAERTHQFNEVVFKILLSSCSLVGGIVIIVVTRRLINIFYDFRVRRKHAYLDELIAKKKSLLESVKETETFKVAKEILEKYDEDFVDESKLQQQASLMQKGVGNIRSPPITQQQLQRIQMSSPQQVRKRMMPPPSQIQQMQQQPHLPHGTPAPPRNDPNNAPSGLHFQGRPQSIKPIRPYAQEAKSGMEKVVDYFFGDGPNSRLALICNQCHCHNGMAFPGEFEYLAYICYMCGHFNPARKMRNASGTDSMSGLSTPMISRQPSTRSLMTAVPDEEVLREAKEDDEETVEAGLEVKNEDHNTSSENETDQEKL
The following text describes a protein:
Function:
Responsible for synthesis of pseudouridine from uracil.
Sequence:
MNLELKADVSEEFSGNRLDRFLKYSLGDEISRATIQKWIEAGYVQGQDGKILDKSSWKVKTGEKYLLSIPPKPPLNLEPIPMELPVILERENFLIIHKPSGIASHSGPGDRSPSLVNGLIYHFKELSKMGGEARPGIVHRLDKPTEGLILIAKNDRAHGKLSELFRKREIEKKYYAWVQGHPPEESGTIDLPIARHPVERLKMTVSPKGRRSITHYKVLKYINSRSGRKFSFIEVGLETGRTHQIRVHFQNQRCPVVGDLLYSRAGSQFESYGLQLLSYFLKFKDPFTNEKIEAILPLSERFLRFEKNAPLL
The following text describes a protein:
Function:
Component of intercellular desmosome junctions (By similarity). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).
Subcellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Cytoplasm. Nucleus.
Domain:
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Sequence:
MNWPFFRAAVVLFIFLVVLEVNSDFRIQVRDYNTKNGTIKWHSLRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSLGQDLEKPLELRVRVLDINDNPPVFSMSTFVGEIEENSNANTLVMVLNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDREQYGQYSLAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMELPTQSISIEENSLNSNLLQIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDFEAMNNLQLSLGVRNKAEFHQSIMSQYKLTATAISVTVLNVVEGSVFRPGSKTFVVNSNMGQNYKIGEYVAWDLDANRPSTTVRYVMGRNPTDLLAIDSKTAIITLRNKVTMEQYKILGGKYQGTILSIDDALQRTCTGTIVINLENGGWKTERPNVNGSTTSAYGLTSGGVTTNGYTTGGGVGTVTFAVGTNGYGVGTGVYQPLRDNVHFGPAGIGLLIMGFLVLGLVPFLLMCCDCGGAPGGGAAFEPVPECSDGAIHSWAVEGAQADPGVLANSAVPCIPVTNANVIEYVDNSGVYTNEYGAREMQDLGGGERTTGFELTDGVKMSGGPEICQEYPGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGAGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKDVEPFPDSDPSWPPKSTEPVCPPQGTEPTGGGHPPISPRFGTTTVISENTYPSGPGVQHPTPIPDPLGYGNVTVTESYTSSGTLKPSVHIHDNRHASNVVVTERVVGPISGADLQGMLEMPDLRDGSNVIVTERVIAPSSSLPTTLTIPDPRQSSNVVVTERVIQPTSGIVGNLSMHPELSNTHNVIVTERVVSGSGITGSSSLLGSAGGGSGGGIGLGSLGGGGGLSSSLGGAATIGHLRGSAEHHFSNTLGSASPTTTRSRITKYSTVQYTK
The following text describes a protein:
Function:
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Subcellular Localization:
Nucleus.
Sequence:
MSRKKGMSREEKLLAMQELMMESQDIWTLKDLERDCPKKKGITSMSVKEILQELCDNDLVSFEKIGSGNFYWCFPSEAFNRRKVLEGKLQAQITELESEISGLQAEIADLEPGREPCQERTELDEIVEKFGKELASIQAESAKYDSLNPNAIRKTQEYTKKALESANRWTDNVYTLKSWIVKTYMLNPSAFDEQFGIGEGFDYFQ
The following text describes a protein:
Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Subcellular Localization:
Nucleus.
Sequence:
MAESTAPDPPTQEVNGQEAPPNPPGETGPNGTASRVDVDPVILSRLENAKAELAMNLAKKKKLDKELAALEATLYSHETAYLTDPSANLFGNIVKGYEAYVKAPPSTSMAGDHHSTRRKRAYTNTIGPTGPTEMVGDAERIFSKSSGSYARALEVRSKEHESAVTSEQESVVPTLHPTETRKKSRS
The following text describes a protein:
Function:
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Subcellular Localization:
Cytoplasm.
Sequence:
MATPDVSVHMEEVVVVTTPDTAVDGSGVEGVKTVLVTTNLAPHGGDLTEDNMETENAAAAAAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQYDEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKIDLSGARVSLSSPTSAEYIPLTPATADVNGSPATITIETCEDPGDWTAAIGDDTFTFWRGLKDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLRDAVLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQHLSNVLMTLTPVSLPPPVKRPRLARATSGPAAMASQVLTQSAQLALGPGVPVPQLTSVPLGKVVSTLPSTVLGKGSLQAPPASSPASPLLGGYTVLASSGSTYPSTVEIHPDASSLTVLSTAAVQDGSTVFKVVSPLQLLTLPGLGPTLQNVAQASPGSSTIVTVPAGAAPGPEEHTATIEVAAMAEDHERK
The following text describes a protein:
Function:
Functions as an E3 ubiquitin ligase.
Sequence:
MEEDTKSELMGELIDSVKEVCLLPECKNVCKKMHGNLVRRIKLLSPLFEELKDSDEAIGQAGIRGFELFRSALDSAFQLLKSTCQGSKVYQALRRNEIAQEFCLITEKIEAALNEISYAKIDLSEEVREQIELVHSQLRRAKARPDYLDLQLDLDLAIAQREKDLDPAVLKRLSEKLELKTINDLKKESLAFHELVISSGGDPGDSLEKMSSILKKLKDYVQMENSEADNSESDKVFSKHRSPVIPDDFRCPISLELMKDPVIVSTGQTYERSCIQKWLDAGHKTCPKTQQTLLHTALTPNYVLKSLISLWCENNGVQLPKQQGASRSKRIGSSVSDCDRGAIISLLEKLLIGNPEQQRAAAGELRLLAKRNADNRVYVLRNGSMEARENAAATLFSLSVIDENKVAIGAAGAMPALIDLLREGTPRGKKDAATAIFNLSIYQGNKARAVKAGIVPSLMQLLKDPGGGMVDEALAILAILASHQEGKVAIGQAKPIPVLVEVIRTGSPRNRENAAAVLWSLCAGDLQQLKLAKESGAEEALKELSESGTDRAKRKAGSLLELIQRVEVVVNQSLL
The following text describes a protein:
Function:
RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Plays a central role in myelinization via 3 distinct mechanisms (By similarity). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation. Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA. Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation. Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (By similarity). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts. Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1. Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (By similarity). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity).
Subcellular Localization:
Nucleus. Cytoplasm.
Domain:
The KH domain and the Qua2 region are involved in RNA binding.
Sequence:
MVGEMETKENPNPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN
The following text describes a protein:
Function:
Component of the exocyst complex.
Sequence:
MLIEIQSWLRQPKVWRFVCFISSVVGLLCYALSSSFNHMFGKWSWWKILLYIVFSCIICIAVLFAKAWESSNSLRLEAHTAFLVLMITSVYSFFVDKVVKGKPDACSLVSCAAFAIMSLCLSRLSRFGFEVDLLYFFSSLLTIQLMKIKVWLVFVGGCFSYSLIKLRSTLDNQDIGSGSLSSEINSSASQLDSPQLREQRASSLIELLENQIEVLKKKNGSIIGAMSKHVDRCLKTNLVYDDQIPVPQIDHDDNLVVDALQFDDDDNIVGDLGATARLMVMAGIEEECCRVYCCWRREFLNESLSTFGLQVQDLNMEDIDNKEKIQCSIKALNVFVRLLFPNERRLCHHIFGKFISSADFAFTEVCRESATRLLSTADALANSFRNTFEELMYEFELVFSGEYSKSIKKDARSVQRSLDIFKDSENLLTCGSGGLLPITHELMKYISDNAIETKSRLNQASQGMLSPSVQVARIARLFERSLKANSKNYNNPSLGYVFILNNRSYIDRHVDPYGLGPIGYDWLQKNKRKIEKNYKLYLTKSWTKIFNFLKLDINEAEANVAVKLMTDKLRSFNQHFDDICNDQSTWLVFDKQLREQIIKSIENILLLAYGNFIGRLQDLLGNHANEYIKYGMIDVQDRLNNLFLVRE
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Subcellular Localization:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MDYFSVKQQFYTGNYRQALQEAEKHKTDDDTVVYYKSMAQLALKEYSKGSGNAGLQAVFDAYVDCRESGALDKLKQAAEAHPGPYSANLVACAQAAGGDYEGALATCKDGDAAELVLTAVQAALLAGQQAAAAALFEAYVAAHEQAGEDEIVLNTAEAYLNFARSREAMGSNFYFFEELCQTFPSWRSQLGLLNLHLQQAHLPEARAIIDLLEDEYYGAMAGAAAFRADLLACKITYAAMNGDETAALRAELQELDAAHPLIQKHLENDASFDAIVEKYSSSIQDAK
The following text describes a protein:
Function:
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Miscellaneous:
MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MSDLISALLLGILEGLTEFLPISSTGHLLIAEQWLGRRSDFFNIVIQAGAILAICLALRQKLWTLATGLGERANRDYVLKIGVAFLVTAVVGLIVRKAGWQLPETIQPVAWALLIGGVWMLVAEHFAGKLPERDVVTWKVAIAVGLAQVVAGVFPGTSRSASAIFLAMLLGLSKRSAAADFVFMVGIPTMFAASGYALLEMYKEGGFGSENWTDVSVAFIAATLTGFVVVKWLLGYIKKHRFTVFAVYRILLGAALLLWLPAA
The following text describes a protein:
Function:
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
Subcellular Localization:
Secreted.
Sequence:
MGWIRTTGHCQHSKKKMMSLKYAAFLLTFIIFNTAKADENKMKAAVNDERPQPLQRRYSEAILASDYSRSVDNMLKKNFVDWLLARREKKSENASEATKREADFQLPDVNMKEKEAQEGFERNTNYFTWLMRNKHRESAYNEAKTMLNQEFVDLLILTDLCKQRFS
The following text describes a protein:
Function:
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
Subcellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
Sequence:
MWKFKVLVAAAVVIIAAQINSVKIVNQEEFEILCGFVRLTLAPAPLIQLSQRIKNEAVGAAVDAIYSEPNQEHLWKKLSPNCEAHQISDRESVCDAYARFKHEAEERLKTSRLTEPELTDYSPDVLDHLEKAFKLYQASELEGKQTSIVTLQEGINSIMYGENDSGGNSLWGDHFRNEDCGTVLGQRPKYAGGALVTDLLCLCAQHVNGSDTKHLCCEGCSWRSNTTVWSEEGGLKLQWEILREKCIGYNMDLANPKDRLKRLREEMECRTVPRGIGSRKGLFVYTYGELEKRELVSCGGEDRQDSGACVLYEWGGTQIQTARIPWMQRLEKLVDMLPNVSEESDRMEKRRRQIENIVYRVNETSKKQPKLEKKEALSQQDTPHPPLGDVLQTFTDNPNTEGEAREKQQVKNDSSDKSVEIKPAEGRTPGIGIRPLKSASKIGTPLTMFLLLL
The following text describes a protein:
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MGLWAWTLNQMLTPKFWTLVRREGFWQTYIRMHRAQSRSSHYAGGQNGPIQCVGQDQFGNKYYEDFDVTHRNQRRWVEYNDYFNPWHTLGDRVPPIWHGWMAHVYDEAPTRTGHSHFVQPFYQKPATDNQSPTPNHYFPQGAMQSLNRLEFIKYHRNRRAAPFEPGQASGFEGKKLVVEKQTYSEDVMASRE
The following text describes a protein:
Function:
Dihydroxyacetonephosphate acyltransferase catalyzing the first step in the biosynthesis of plasmalogens, a subset of phospholipids that differ from other glycerolipids by having an alkyl chain attached through a vinyl ether linkage at the sn-1 position of the glycerol backbone, and which unique physical properties have an impact on various aspects of cell signaling and membrane biology.
Subcellular Localization:
Peroxisome membrane; Peripheral membrane protein; Matrix side.
Sequence:
MESPSSSNSYFSVGPTSPSAVVLLYSKELKKWDEFEDILEERRHVSDLKFAMKCYTPLVYKGITPCKPTDIKCSVLSSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFFAFTLSKIFKQIFSKVCVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFILYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYNLVPRYIPQKQSEDMHAFVTEVAYKMELLQVENMVLSPWTLIVAVLLQNRPSMDFDALVEKTLWLKGLTQAFGGFLIWPDNEPAEEVVQASILLHSNIASLVRDQVILKVDSGDSEVVDGLIFQHITLLMCSAYRNQLLNIFVRPSLVAMALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKDFEEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLIGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVEKKKINNNCIFNVNEPATTKLEEMLGCKTPIGKPAAAKL
The following text describes a protein:
Function:
GTPase-activating protein (GAP) for CDC42 and/or RHO1.
Miscellaneous:
MISCELLANEOUS: Present with 254 molecules/cell in log phase SD medium.
Sequence:
MSADPINDQSSLCVRCNKSIASSQVYELESKKWHDQCFTCYKCDKKLNADSDFLVLDIGTLICYDCSDKCTNCGDKIDDTAIILPSSNEAYCSNCFRCCRCSNRIKNLKYAKTKRGLCCMDCHEKLLRKKQLLLENQTKNSSKEDFPIKLPERSVKRPLSPTRINGKSDVSTNNTAISKNLVSSNEDQQLTPQVLVSQERDESSLNDNNDNDNSKDREETSSHARTVSIDDILNSTLEHDSNSIEEQSLVDNEDYINKMGEDVTYRLLKPQRANRDSIVVKDPRIPNSNSNANRFFSIYDKEETDKDDTDNKENEIIVNTPRNSTDKITSPLNSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQGIQTSTSKSMNHVSPITRTDTVEMKTSTSSSTLRLSDNGSFSRPQTADNLLPHKKVAPSPNKKLSRSFSLKSKNFVHNLKSKTSEMLDPKHPHHSTSIQESDTHSGWGVSSTHTNIRKSKAKKNPVSRGQSDSTIYNTLPQHGNFTVPEFNHKKAQSSLGSISKKQNSNDTATNRRINGSFTSSSSGHHIAMFRTPPLESGPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDSTKVDATDESATSLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERLLNDVDNLTREKDKQSASSRESLEQKENIATSITVKSPSSNSDRKGSISNASPKPRFWKIFSSAKDHQVGDLESQQRSPNSSSGGTTNIAQKEISSPKLIRVHDELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIHDFDGEKDIVDMKERNYIVEFILGNYRDIFKQA
The following text describes a protein:
Function:
Involved in the regulation of tiller growth angle. Promotes horizontal shoot growth. TAC1 and LAZY1 play opposite functions in the regulation of tiller growth angle.
Miscellaneous:
MISCELLANEOUS: Plants silencing TAC1 exhibit erect tillers with a very small tiller angle.
Sequence:
MALKVFNWLNRKKHSNVEYCTINENKAMEEKEDSLRASVTEQDTEALLLRDVLINGILAIGTLGHNVNSLCPESCIEQDEPIIMCDEKVEQEKCEEEKAEAKQDTPVTAPSEPASALEPAKMHSSSMKEDNFMCFVKEEILMHGMEVEDVPNIQERPLLMLEKVEKVRTTLADLFAAEAFSSSDAEDKCYPKIVIVAGASTSKPTSCMEKMHHKKPTKPTSKPLKATRKLSRVMRKMLGKKIHPEQLNGRSNAEGPVTA
The following text describes a protein:
Function:
Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
Subcellular Localization:
Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Sequence:
MSPSPPPTTSTSSSLILLPPSPASSHSSLTFEEISFNYNNLLEDENSQQCDTTLESGDLVTTHGRQANDTKNGEESKRQEVRRPGNIRRTAIKILEGSDQRVEAPFAREVAIKGWKIVGGESWTDVAKLGAYVVYDIDIKLKDGGKLNILRRYTDFVRLRKALRIKYHHLWQAIPPLPGKMHIAKFSPKFLEERQSRLQRFLRGVILHPEMGQGGSGSIVGTWVLGDRQP
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization:
Nucleus.
Sequence:
MSSDSFQRQLVQRTNTLNSSIDNATLTILSRFQDILDIAINEGKDKYTVAPEVYQIECHTVSMVRAVEQLLDVSRQIKSYWLTNSLSTSFPTVDYSEPDLEKVKRTLTKLQNHLLEVSLIEPEASETTEAPTVSDT
The following text describes a protein:
Function:
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Subcellular Localization:
Nucleus.
Sequence:
MASTSQQNEEEPGSSSVVNPVDEVRAMTWGSELKEDVFLRWSQGFVFSDDEPMALLQYEGGPCAIIAPLQAFLVKNLLFSQESQCEEGTESWRQTNGDQRKHLLLCAMQDVISSVSSGSYFLVLQEDKQELTIENVAGSSDGEPTHVTFHRNLRIQTYKSEDELRGALMTTYHMFVGHGGVLLFLYSVLLTKGLAIIQEEMEDPSEPLIDGIYGHGNQCLINLMVTGRAVSNVFDHEKDVAGLQMKGISKQSLIGFLTILENLKYCEVGTLLKNPNYPIWLLASETHLTVFFSRELALVATETKWEEARRVFSEYDTEGSGFIQCAMLQNVLEALELVAVPEYVEFMTQRLDPEKCGIVLQNMFMAEFFPDEPDRLLPEYFTVYHYNGISRSNPNSKVMFLKGRGSAPNPGELEVLTEATPLKSCLRTKWPTFEADWENNVKPSIN
The following text describes a protein:
Function:
Peroxisomal import receptor that mediates the peroxisomal import of both malate synthases MLS1 and MLS2 in oleate-grown cells. Recognizes the C-terminal peroxisomal targeting signal PTS1 sequence SKL of MLS1 and MLS2, probably via its TPR domains. Interacts with the PTS1-receptor docking protein PEX14 but not with peroxins PEX1, PEX3 through to PEX8, PEX10, PEX11, PEX12, PEX13, PEX15, PEX17, PEX18, PEX19 and PEX21.
Subcellular Localization:
Cytoplasm. Peroxisome membrane; Peripheral membrane protein.
Domain:
The WxxxF motif is involved in the interaction with the PTS1-receptor docking protein PEX14; The TPR repeats are involved in the interaction with the C-terminal peroxisomal targeting signal PTS1 of MLS1 and MLS2.
Sequence:
MNEVTCSITGDNPIHKINNGLGLKWNNLGKFSDFQTNDSAARDARTIDYIFTNCQTGSSIGKIDFRAALPADKSQHSGVSEKEFSRLENQWSKEFSCFPKNKNADVTKPSRNKHEKRSANLHNRYFAQYYSTAYQQNRIYPCRISYNEHSSVSNGWEFQFKSIENQLLNELKIENNVEEKTVGYEYVAEYEETIDFMHMLSSVPQTYQFLKSNIYITERDPYKIGCVLMDNGSNLNEVVMAFEAAISQDPSHINAWLKLGIVNFENESESNGELALRNCLNLDPNNTIALENLAIHHINQQNESESLKLFHKWILSKFSKVFQPSAGENKDSINKIPKKAHLAHILESLLNMGIEKKDQYDIYSVLSILYYSDQKIKQSQKCLEFLLLEKPNNGTIWNRYGAILANTKSYHSAINAYNKCKQLRPNFTRVRYNLAIAYMNKGDYVKASKMLIEVILLRSKGYEHNKAKMQNKFMQNLKNALIASKNFDSLDLINGSHNTESLISTLKAIYNKMD