lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular Localization:
Cell projection, cilium, photoreceptor outer segment. Cytoplasm, cytosol. Peroxisome membrane.
Sequence:
MVGSTLSPVPWLPSEKSTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSQLGLHLLKVPCSSLCADSSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVVAALRHLLLDEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNLGLAGGLTEEDEGELCAAGFPLLAEDFGQALELQQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQHKFAAC
The following text describes a protein:
Function:
Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux.
Subcellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membranes via an N-terminal amphipathic intramembrane region.
Sequence:
MAPGQMPHQPAPWRGTHPLFLLSPLMGLLSRAWSLLRAPGPPEPWLVEAVTEADQGGAGLEDEAKASLATYHALWGRHPQEETKDSGAAEEDREASPGACPNLEAKHSLPEAWGLSDDDDEKYGGEEATGVPREQKEFMDGQPAPLPLSLLIRSLPDLPGEEESKEEAVTGGGGNEVTAFSFPLSHWECCPGEEEEEEEENGEAVRVCRPVNGATEERTQTEAATKTSMSPSSVGSHLRAWECCSGKESEEEEKDKQAEKGDADPGPHFTSLAQRPSLRTWQHPSSAITEEEEDRDSEEMGASSSVPLTSAFLSDWVYQPEDTEEEDEEEEDCDSEATEDEGEAEVSSATPPPSAFLSAWVYRPGEDTEEEEDCDSEATEDEGEAEVSSATPPTSAFLSAWVYQPGDTEEEEDCDSEATEDEGEAEVSSATPPPSAFLSAWVYRPGEDTEEEDEYEDEDNESGAADLGPSPSLQTQSALLRDQIYQPGEKTDGGEAAEKWGEAESCPFRVAIYLPGEKPPPPWDPPRLPLRLQRRLKSAQTPTRHQDLERLLKTRKVRFSEKVSIHPLVVWAGPAQAARRGPWEQFARDRSRFARRIAQVQEELGPYLTPAARARAWARLGNPPTSLATVPAPTQTSPMTPIQATPLSHALASPSPPCVSPSLDLSGRRG
The following text describes a protein:
Function:
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular Localization:
Endomembrane system; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MANYGTTQRIPTSSTPQSTADTYEPEPKAPHEKFYSDFRIYCPINIPSTSEAAGVRIMRNMCNFGLYYTLFVWIILFITLIPQRKVSLILFVIMTYVTTLYFLLLRAFPNSVVLHRIIDKRVVLALLAIATAVQLILTKAGIHLAVTLASSVPVLLVHAVLWASYDAFEVEDSSAKGELAPLAGHSESVADNSDAV
The following text describes a protein:
Function:
Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Subcellular Localization:
Cytoplasm, cytoskeleton.
Sequence:
MSSILESAKGIIKEARELAYLGKYPEAIMKFKSQIDTLSQQLEKNKGDELLYQEWSKLVTDIKEELDLTQILFDFTKGNSNSNFELNKIAQQQPSPQKPRVVQECPEFQEDNRQPRLPFNQIPFQHHHRENTSPRSKANQFQISPPKQKAQDPDEIFFGGLRGGNDGKKPNSNNNNNNGNNLNQNPSNYFNNNSNNNNNNNNNNYNKRQTNNNPPPKDPDVWDPPSKKVDKPKQSQKDQKSNNIFKPQAQPQPQPKSNQRREYDKPWKNNAVGEKKPTEGQRKTFHDHVYPDGRGPDSDLIQMIEREVLDLTPNVSFEQIAELELAKDTLQEAVLLPIFMPQIFTGIRRPCKGVLLFGPPGTGKTMLAKAVATTGKTTFFNVSACTLASKWKGESEKLVRLLFEMAKFYAPSTIFFDEIDALGSKRGDNDGDSARKVKTQMLIEMDGVSGAATSGEERKTVMCLAATNRPWDLDEALIRRLERRIYIPLPSDTGRKLLFEINLNSLKLSPNIIWDQLVKKCDGYSGADIANVCREASMLPMRRKLKEEGGFQKLQQKYEDISNVPLEQKDFDEALKIVNKSVSTEYLKEYENWMKDFGAG
The following text describes a protein:
Function:
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Subcellular Localization:
Cytoplasm. Cell projection, lamellipodium.
Sequence:
MGQADISRPVNPDGVEEIGQPTADLGMVMDCVEAGDITPPTKRKSKFSGFGKIFKPWKWRKKKSDKFKETSEVLERKISMRKPREELVKRGLLLEDSEQGGEDPGKLSHATLKNGHTTLIGSTRSSSPVQVEEESERIASLRKPVPEEEPKKRLGSSGSQPHSEAEFVPESIPKQPLLPPKRHLSSSHEANEGQAKDATSSGSLARPSSSASTTAITTAPAATMAATNPAKTVHSSGPPSQAPRTLPAAPASTHTTATLSLTHTGPAKQPPIPPPKPTHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGIPSALVPTSESAAATTATKAPSDQREKSACSVGSEPLLTPSSSPLPAHIPPEPPQSPPFPAKTFQVVPEIEFPPSLDLPQEIPQQESQKREVPKRMLDHSFGEPQVPPRLPPVPLHIRIQQALTSPLPVTPPLEGSHRAHSLLFENSDNFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQSHIFAFDEDVASTSVIPKLPQCLQEEEEGKESDSDSEGPIQYRDEEDEDESHHSALANKVKRKDTLAMKLNHKPSEPEMNMNSWPRKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAHDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEDSKHFTRYHRP
The following text describes a protein:
Function:
Part of the ABC transporter complex GbuABC involved in glycine betaine uptake. Involved, with BetL and OpuC, in osmoprotection and cryoprotection of Listeria. Can also uptake carnitine when carnitine is abundant in the growth medium.
Subcellular Localization:
Cell membrane; Lipid-anchor.
Sequence:
MLKKLITTAVLAMLIFTLAACGTTLAPYDAKKDLGEQINYTITGIDAGAGIMLATQNAIKDYHLDDDNWQLQTSSTAAMTSTLQKAMKDKRPIVVTGWTPHWMFTKFDLKFLDDPKNVYGNAENIHTIVRKGLKEDKPSAYQVLDNFFWTAEDMSEVMLEVNDGVDPEEAAKKWIKNNPDKVAKWTDGVEKVDGDEIKLTYVAWDSEIASTNVVAEALKQVGYKPTIQAMEIQPMWASVATDAADGMVAAWLPNTSGIYYKDYKGKFEDLGPNLKGAKIGLAVPKYMTNINSIEDLKTSK
The following text describes a protein:
Function:
Involved in resistance toward heavy metals.
Subcellular Localization:
Cytoplasm.
Sequence:
MLDEKSSNTASVVVLCTAPDEATAQDLAAKVLAEKLAACATLIPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALLECLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
The following text describes a protein:
Function:
NADPH-specific quinone reductase. Is most active with quinone derivatives and ferricyanide as electron acceptors. Can use menadione, 1,4-naphthoquinone and 1,4-benzoquinone. May work in concert with YgiN to form a quinone redox cycle.
Miscellaneous:
MISCELLANEOUS: Overexpression leads to increased resistance to the tumoricidal agent DMP 840.
Subcellular Localization:
Cytoplasm.
Sequence:
MSNILIINGAKKFAHSNGQLNDTLTEVADGTLRDLGHDVRIVRADSDYDVKAEVQNFLWADVVIWQMPGWWMGAPWTVKKYIDDVFTEGHGTLYASDGRTRKDPSKKYGSGGLVQGKKYMLSLTWNAPMEAFTEKDQFFHGVGVDGVYLPFHKANQFLGMEPLPTFIANDVIKMPDVPRYTEEYRKHLVEIFG
The following text describes a protein:
Function:
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MVTATASTPFSLSSSVVFTRRRNFKRFPVCASLSPEVSPLLRAAHHTVDNYVKSGMIIGLGSGEASDFAIRYLGQQLGSGSLHNVVGVPMSARSASEAAKYGIPLEYYRDGVQIDFAFHDADAVEENTLIAVIGRRRSSQEDDYILKQKSIVKVADEAVFMIKEEQYKAGLEGSIPVLVQSLNWLAIAEEIDDLYLGDAEVWRRASVENEGPLGGDFPIVTSDGHNILDVIFTTPIRSLADLATSLDKIDGVVDHGLIIKTRCTVVIAEETVVRSVTLQTSALEGGVRTYGQTLQK
The following text describes a protein:
Function:
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
Sequence:
MLSVYEKVNALDKRAIEELFLSEDILMENAAMALERAVLQNASLGAKVIILCGSGDNGGDGYALARRLVGRFKTLVFEMKLAKSPMCQLQQERAKKAGVVIKAYEENALNQNLECDVLIDCVIGSHFKGKLEPFLNFESLSQKARFKIACDIPSGIDSKGRVDKGAFKADLTISMGAIKSCLLSDRAKDYVGELKVGHLGVFNQIYEIPTDTFLLEKSDLKLPLRDRKNAHKGDYGHAHVLLGKHSGAGLLSALSALSFGSGVVSVQALECEITSNNKPLELVFCENFPNLLSAFALGMGLENIPKDFNKWLELAPCVLDAGVFYHKEVLQALEKEVILTPHPKEFLSLLKLVGINISMLELLDNKLEIARDFSQKYPKVVLLLKGANTLIAHQGQVFINILGSVALAKAGSGDVLAGLILSLLSQNYTPLDAAINASSAHALASLEFKNNYALTPLDLIEKIKQL
The following text describes a protein:
Function:
Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
Miscellaneous:
MISCELLANEOUS: Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.
Subcellular Localization:
Cell inner membrane; Single-pass membrane protein.
Sequence:
MINRQQGFTLLEVMAALAIFSMLSVLAFMIFSQASELHQRSQKEIQQFNQLQRTITILDNDLLQLVARRNRSTDKIMVLGEEAIFTTQSRDPLAPLSEAQTLLTVHWYLRNHTLYRAVRTSVDGRKDQPAQAMLEHVESFLLESNSGESQELPLSVTLHLQTQQYGGLQRRFALPEQLAREESPAQTQAGNNNHE
The following text describes a protein:
Function:
Transcription factor that establishes leaf shape by repressing growth in specific subdomains of the leaf. Negatively regulates knox homeobox gene KNAT1/BP expression.
Subcellular Localization:
Nucleus.
Domain:
The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.
Sequence:
MGITKTSPNTTILLKTFHNNSMSQDYHHHHHHNQHQGGIFNFSNGFDRSDSPNLTTQQKQEHQRVEMDEESSVAGGRIPVYESAGMLSEMFNFPGSSGGGRDLDLGQSFRSNRQLLEEQHQNIPAMNATDSATATAAAMQLFLMNPPPPQQPPSPSSTTSPRSHHNSSTLHMLLPSPSTNTTHHQNYTNHMSMHQLPHQHHQQISTWQSSPDHHHHHHNSQTEIGTVHVENSGGHGGQGLSLSLSSSLEAAAKAEEYRNIYYGANSSNASPHHQYNQFKTLLANSSQHHHQVLNQFRSSPAASSSSMAAVNILRNSRYTTAAQELLEEFCSVGRGFLKKNKLGNSSNPNTCGGDGGGSSPSSAGANKEHPPLSASDRIEHQRRKVKLLTMLEEVDRRYNHYCEQMQMVVNSFDIVMGHGAALPYTALAQKAMSRHFRCLKDAVAAQLKQSCELLGDKDAAGISSSGLTKGETPRLRLLEQSLRQNRAFHQMGMMEQEAWRPQRGLPERSVNILRAWLFEHFLHPYPSDADKHLLARQTGLSRNQVSNWFINARVRLWKPMVEEMYQQESKEREREEELEENEEDQETKNSNDDKSTKSNNNESNFTAVRTTSQTPTTTAPDASDADAAVATGHRLRSNINAYENDASSLLLPSSYSNAAAPAAVSDDLNSRYGGSDAFSAVATCQQSVGGFDDADMDGVNVIRFGTNPTGDVSLTLGLRHAGNMPDKDASFCVREFGGF
The following text describes a protein:
Function:
Catalytic component of endonuclease SceI (Endo.SceI), which cleaves specifically at multiple sites on mitochondrial DNA and produces double-stranded breaks.
Subcellular Localization:
Mitochondrion.
Sequence:
MKKQNLNSILLMYINYIINYFNNIHKNQLKKDWIMEYEYMYKFLMNNMTCFIKWDNNKILLLLDMYYNVLYNYHKQRTPMSNKRLMNSKNIMDYKLLYTYFYILNKMKMEMDNYNNNNNNISLKYNELLKNIMNNLNYKTSNIETNLSNNFYLMDKYLINKYMKYLDMLNMIPNNYMFNNINYKGKLNIKTVLDLNNNEFYDYLSGLIEGDGYIGPGGITITNHANDVLNTIFINKRIKNSILVEKWMDTLKDNPYFVNAFSINIKTNLAKEKIFTNIYNKLYSDYKINQINNHIPYYNYLKINNKLPIKNIMDIKNNYWLAGFTAADGSFLSSMYNPKDTLLFKNMRPSYVISQVETRKELIYLIQESFDLSISNVKKVGNRKLKDFKLFTRTTDELMKFIYYFDKFLPLHDNKQFNYIKFRFNTFIKSYNWNNRVFGLVLSEYINNIKIDNYDYYYYNKYINMHNARKPKGYIK
The following text describes a protein:
Function:
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Subcellular Localization:
Secreted.
Domain:
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence:
MNILRLLLATLLVCLCLLTAYSHLAPEEKPRDDRNLRSNSSMNMLDLSSVSIVALNKKSKKISRKEAEKKRSSKKKASMKNVAQPRRPRPPPPAPCVATRDSCKPPAPACCDPCASCQCRFFRSSCSCRVLNPTC
The following text describes a protein:
Function:
May catalyze the transport of undecaprenyl phosphate (UndP) across the cytoplasmic membrane, from the external side to the cytoplasmic side.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MSFHQVEEWFEIFRQFGYLPGFILLYIRAIIPVFPLALYILINIQAYGPILGILISWLGLISGTFTVYLICKRLVNTERMQRIKQRTAVQRLISFIDRQGLIPLFILLCFPFTPNTLINFVASLSHIRPKYYFIVLASSKLVSTIILGYLGKEITTILTHPLRGILMLVVLVVFWIVGKKLEQHFMGSKKE
The following text describes a protein:
Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Subcellular Localization:
Cytoplasm.
Sequence:
MRAKRMIEINGSEGEGGGQIVRSSLALAAVTGQPIRLTNIRGGRKKPGLLRQHLAGVRAIQQVCSGEVSGDQLGSGELTLVPGQLSGGDHHFEVGSAGSAVLVAQTILPVLLHADAPSTITIGGGTHASWAPPFDFFLRCYLPLLAGMNAKVEAEIESHGFYPAGGGRIVMKVEPSTGITGLALTDRAGSLQPKVTALVSRIPETVGQRECDVIARKTGWGQKAFQVVDVQQSGGPGNVVMIELGFDNISELIIGFGKVGVKAEQVARAALREARAYLASDVPVGVYLADQLLLPMGLAARNGHRSEFRTGPLSLHSQTHIDVLRNFLEVNIQCVSNENGSVHVIVEGGNDCIGCSSPLREAKRV
The following text describes a protein:
Function:
Required for normal cell proliferation and chromosome stability. Plays a role in DNA repair during replication.
Subcellular Localization:
Nucleus.
Sequence:
MDEFSFPFQPYDIQLNLMREIRQCIEQRKIGIFESPTGTGKSLSVLCSTMTWLEAEELRISTDLSTRLGEVHTKITECDKITTADNWETAVREKMRAQDVETEILEQIQSRERLQSRIDQARRGMVEVSRKRKAPARDTDQFLEPQDEAAPSEEYNNDEKSEKQRDSDFFDDVDEEEEKPLKCLKIFYASRTHSQLEQLAEELAKTRFQPRIVTCASRGTLCVNEEVKKLKLNHLINEKCMELRKNGMSEKEKVQKLEKGTTKKTKTCATSCEFYNSTQIEDVVNGVLSNKLKSTLEVSKQGKLSNGCPYFATRKSVPQCQLVLLPYQVLLHDGTRKAWGIELKDNVIVLDEAHNVLNTISSLYSAEISTKSLTLALRLIREYNAHYKLKLLAHNLLYMKQLESLTSKMLIFLNSQSKEDVMTMAQLARNLNILEINLFKLAEYMEKTDLCKKFHGFYMRLQKEEIKKENEKPKLTGIQKLMAAKEAEPEPEAEPLPPPKPVPSPLFSLKSFIDALTNKCEDGRIIVEKSATEAKFRFMLLNPADRLSEVVTSARATILVGGTMEPAQLLVETLSRGSIGADSIRRFSCCHVIDDSQLLAVTVERTVDGKPFQLTYQTRGADTTLRSLATSIQALIPHIPNGVVIFVPSYDFLFNFQKKMKEFGILKRIEEKKAVFTESRQPTSDVWDRFSRAAKTSKGAILFAVVGGKMSEGINFCDELGRAVIVIGLPYPNKTSVELRERMKFLDTQMPNGGNLLYESLCMHAVNQAIGRAIRHRRDYAAVYLFDDRYAKESTRRKLSTWIGDRTQVKLGFGEIIRKTRSFFEANSKK
The following text describes a protein:
Function:
Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections.
Subcellular Localization:
Nucleus.
Sequence:
MVPNTTKQVLNSLILDFLVKHQFQDTAKAFSKESPNLPSIPPLMDCSQGFLLEWWQVFFDLFQVRYGDGNSNNNPNNKLYHDYLRVQETQKHLFSQLPLIQQQQQQQHHFQQQQQQQGQQGQPFSQQQQRGIGVASGMQNQQHQFAPQHQGQPQGPGQTPQPPGSATNANFPINMPPNSNPQQQMFPINQQFAQMPNGQNQPSMEQQQRMAMMMKQQAMAAQRQQIPMNGLDPQQQQQMMNAVGGGPGNLNLQQQLFLQQQQQQQQQPKTTFQQQAQNQMNNLRQQAAMVAQQQQQQQQQQQQQGQLQGNLASAMGDSSSKNNSPVGARSNQQSTPQQNAAPAPSPHPSQQGQAQAQHNFQSQQQQQQQQMTKMAGSQGMKKNGQMSNGTSNNSSGRNNNALRDYQNQLMLLERQNKERLEFARNTGNSDSNPLSNGMMFAGQNQYSNSNQNQNQLPPNQQQPTPATFHPPPPPTTANGPQGQFNQKPSPATSNNSPALGNKSSPAMGNKKSKKESNSKKGKKANSNASTTANNKTSGQTTPNMSQPPSAGTEPKQPQPTEQMRQLQDKQQRPGSNTPSMGKKDFQPLTPRSEPISGETTKKKRKSGKLNDNNENSNGNSPKKQAKTNANSKNLDPIIKEEENGVLSLKKESSTSLQDQDLDLNPPLAPTQATAMSNTFNDDPFDVHLLDTQHHHQQNSNNSNHNRGQNLSNGSNNLSVSGPGMGMNNSVFGDSTHAFDINFNIDSLDDIWTTTGPGGDITGTGSGSGGAGGTDDDNFMGMNWAADPIENGD
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MDSHVNLKPKISKQIQNDQKKQFYSDDDAEITPKRPMIAKPSKFSKGEAQQYQTDDSDNTPLKLSSPKSPKGQNKLSKFKQKENHIEKDSDIQFDSSENENKEKPQNRQNHQQADNYDIQEMSRQMELKYQTPKQAYQHPPIYKSNSTKLVITKNLNIKEHPFRHLVYGKNINQNDFLRFLQIVQSGLLYARNSLKAPSNIFLRSRYIRLKEPNQKKSKLLILDLDETLIHITITLQDDDEERFDLCFNVRPFCNEFLKEMSKYYNIHLFTASSELYANAIVNHLDPKRQYINEILCRNNCFETKNGFFIKDLRIITNRTLKDIVIVDNLPHSFGLQLENGIPILEYLDDQKDEELKLLQHYLIKLSKEDDVRLFNKQNLKLLDLVEYKLNI
The following text describes a protein:
Function:
KAR1 is required for function of both intranuclear and extranuclear microtubules. KAR1 helps localize CDC31 to the spindle pole body (SPB), CDC31 then initiates SPB duplication via interaction with a downstream effector.
Subcellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Sequence:
MNVTSPKDGNHSFSKKNRFNTNKPRFHKLNEQAQSINLPEDRDSIVSSNTTSIMTDDAFDYNEGIASRTKNINSDSDRSNDTIKQNNYNKRETGYNPFYNGSGINQRYTQFRKREFEPTLAENKAEEYISDEDNVKIDEDNIENELQFTPKIKEASILRSSLLGQRNVLNTRNPKSKESHIKVKPIINNKSSSQRKSSAALRKQLGKPLPLPYLNSPNSDSTPTLQRKEEVFTDEVLQKKRELIESKWHRLLFHDKKMVEKKLESLREYERKRMPPRGTDVSSSEQDNSFKISTPTKSYVSLEQKPLPNLSAMNNFNDVTDNKEKEETNNNILKFQAQRDPLQILQSEIEMHTKKLDTIIELLKDDTDSKEKRKVVTNDNAAPEQMVNKGWRKNVMMIYKKSGNIMKKYREYFLWTICILILLYCNIYVYYRF
The following text describes a protein:
Function:
Essential protein required during embryogenesis. Believed to act as a component of the putative class C core vacuole/endosome tethering (CORVET) endosomal tethering complexes. CORVET is required for vacuolar transport of SYP22. Involved in root development. Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway (By similarity).
Subcellular Localization:
Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Co-localizes with VAMP727, VPS18, RABG3F and RABF2B at cytoplasmic punctate structures.
Sequence:
MSKSRAVVELTARFDLGGDDKIRALSLSPISDSQTLVYLGTYSGSLILLSLDTLTNTVSRLASVSLSPSPVESIFVLGEERGRVLALCNGYLFLLDSLLSQPAKRLGGLLKGINVIAKRVRGRDSSSTDLLPSEISTDSSSSKKFLQLLGAGNLVSDVRGNDSRHERVQQGHYVFAVAIGERMLLIELQCAEKEGLSGSFVVLKEILGIGGIKTLVWLDDYVIAGTVKGYSLISCVTGLSGVIFTLPDVSGPPLLKLLCKEWKVLLLVDNVGVVVDTNGQPIGGSLVFRRRPDSVGELSFYLVTVGDGKMEIHQKKSGACVQSVSFGPQGCGPSLLAADEAGDGNLLVVTTLSKLIFYRRVPYEEQIKDLLRKKRYRETISLVEELDSQGEISKDMLSFLHAQIGYLLLFDLRFEEAVNQFLKSEKMEPSEVFPFIMRDPNRWSLVVPRNRYWGLHPPPAPFEDVVDNGLMAIQRANFLRKAGMDTPVDEEFFSDPPSRADLLDSAIKNITRYLEISREKGLTLPVREGIDTLLMLLYRALNRVEDMENLASSGNNCVVEELETLLTESGHLRTLAFLYATKGMGAKALAIWRLFTKNYSSGLWQDSDDLVPYLHDNELIRLSGKEAAAAEAARILEEPCDPELALQHLSWIADVNPLFAIQVLTSDKRTEELSPEQVIQAIDPKKVEIIQRYFQWLIEERDYTDPQLHTSYALSLARSALECVEVQNGIQEADVPNGSEAHDSNVGSISLFEVDVRERLQAFLQSSDLYDPEEILELVEGSELWLEKAILYRRIGKETLVLQILALKLEDCAAAEQYCVEIGRPDAFMQLLDMYLDPQNGKEPMFKAAVRLLHNHGESLDPLQVLDKLSPDMPLKLASDTILRMLRARVHHHRQGQIVHNISRALDVDSRLARLEERSRHMQINDESLCDSCYARLGTKLFAMYPDDTIVCYKCYRRLGESKSVTGRDFKRDVLIKPGWLVNR
The following text describes a protein:
Function:
Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
Subcellular Localization:
Cell membrane; Peripheral membrane protein.
Sequence:
MRSQRELTSPMTPLENPGDISDKPRLTTQKLSLGYGQQLIINKLSLSIKNGAFSVIIGPNGCGKSTLLRALSRSLLPQNGSIRLDQQDIQHYKAKVFARQLSLLSQGASISETLTVFDLVSRGRYAHQSFFHQWSTEDERIVKAAISAVNLESLVQQRVSELSGGQRQRAWFAMTLAQHTPIVLLDEPTTYLDIAHQIEMLDLCQELQQQGKTLVLVLHDINQALRYATHLIMLKEGQIYAEGLPESIVTEDSIAAVFGLRCRIITDPESGKPLVIPRRQSR
The following text describes a protein:
Function:
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular Localization:
Mitochondrion.
Sequence:
MALLSAAPRALRLPRRLPLGAALPALRALATPAAAQKVPVSLIAALRKQHPVPLAQAREALERSGLDLAAALDYLRTSTSASAEKKAAKVSGRDTNEGLIAISLLGGKRVGMIHLACETDFVARNQVFLDTARGVAETTAFLDVPGDHEKPQIASSPYAFDPILDFPTESLLSAPLISLPAADTADGSLSPLPTSEPTTIKQSLLSSLAQTGENLKLLRAVSFAAPFPSTPDVRFVPGGYAHGGITDKEGKVGGIVVLSVTSADPEKPIASIIHGPGGDDLEKAAESLARTVARQVVGFPTKVIDRGDRAVDDEEVLMEQPFMMFNGDSRSVKDVLAEWGKERGVVLRVVGMRRWAVGDEIEIKEKETDA
The following text describes a protein:
Function:
Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
Subcellular Localization:
Vacuole membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Sequence:
MITMPDYRPGMNGIIIGLLSSFGSAILIGCFFLIFYFFRCTTSGRIFLDRIGRPGEYDDEQQFLREEAEALETMDDMQRTEYLRAKAFIAANPPESLQTDISLSQYLAIQEKGVSAWEFEPELEIANCFVEARTEIEFFDSECTVMSNLPVPKQNEVYYWEAKIYDKPENTLISIGMATKPYPLFRLPGFHKYSVAYLSNGTRRYNQPFNATSYGPQVVQGDVIGVGYRPRSGTIFFTRNGKKLEDVVHGLKSQNFFPSIGANGPCIVHVNFGQAGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLEAGTKDGFTSTLGRGRGYSHPVQTYSRQGLAAVDSSHNRTRSGNFRMFPPTSPGPVRSPTDISLAHLVPTEDAGEPSSSAAALVDQDGQPITGGFLSPDQPPPEYTSPVNSRPGSRRHSSDSENTPLIQLSGRSRGASSATARPIQSGGSHNRPRAGSHRPPSPPIPSYQDAVRQGAGRDRSDSTRSARDSS
The following text describes a protein:
Function:
Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.
Sequence:
MSLLRTLDRTSAVSNTNARPFLTFLCPALQNKKSRRSFSKSAVSNSPRAPRSGEHVEAFFIQALVRAGTHRGHVKQLSTLREILPYTPHKFGTRRKSTWQSQDSQEAKSEGKPKRSGPIKKIRQFAKSELEALVDYYGIEVDTRPEQDPPDEEGSLVWNVGNDHEPWPLQNRTDGRYIKRIEKLLEDDESSHDKIFKTYKMLPSPGVVYMTQETIRGLLHHMSIVERPTPLAMQRFLSILDDMKNAHIHITRSEWTSAIYLTGRAMGAVSTDDLQSALHLWRDMEHRAGVKGGFVTLNVLFDISVKAGKYQLAETFLQELKKRKLPLHRHFRVSKIYYHGIMQNGNGVRDTYQDLVKAGDIVDTVVLNAVIAALIRAGEPGAAEHVFERMKRLHSGRSVAAPGHKFFNRTWRDRRALGLHLTHEAREYKRINDEDALKELQDYAPVAPNSRTYALLIRHQAGVAGDIDRVYDLMQEMRYNSVPLEGTVFITIFHGFNKFGGIRYSEWTRNKLENIWAQYLKALQDGLECTWISTIAVIAALKAFAKCADLDRTMQVWDEIRKMWQPNEEELEKVLKMLRKLFPLRDGFFDTQRPMT
The following text describes a protein:
Function:
Converts acetoacetate to acetoacetyl-CoA in the cytosol.
Subcellular Localization:
Cytoplasm, cytosol.
Sequence:
MSKEPRAGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALENYDDLYHWSVESYSDFWAEFWKFSGIVFSRMYDEVVDTSKGIADVPEWFKGSRLNYAENLLQHKENDRVALYVAREGKEEIVKVTFEELRQQVALFAAAMRKMGVRRGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHSHMDKLQRVVKGLPDLKKVVLIPYISSREKIDISKIPNSVFLEDFLATGQGDQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGVGWMMWNWVVSALATGAAVVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMRPVETHSLQTLHTILSTGSPLKAQSYDYVYRCIKSSVLLGSISGGTDIVSCFMGQNPSIPVYKGEIQARNLGMAVEAWNEQGKAVWGESGELVCTKPLPCQPTHFWNDENGSKYRKAYFSKFPGVWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVEAFEEVLDSLCVPQYNKDGEERVILFLKMASGHTFRPDLVKRIREAIRLGLSARHVPSLILETQGIPYTLNGKKVEVAVKQIIAGKTVEHRGAFSNPETLDLYRDIPQLQDF
The following text describes a protein:
Function:
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization:
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
Sequence:
MKKKREKNCMGFYLVVHQTNAPPAPSADAHLPRSARLGPKDRIFRAWWRLPLGGVQRRRGSPRLGGGVRRLPPPSLASRLAPSPASSTNRPTTLRSRSCYGGSCPSAMINFVLLISRQGKVRLTKWYSPYTQKERTKVIRELSGLILTRGPKLCNFVEWRGYKVVYRRYASLYFCMCIDADDNELEVLEIIHHFVEILDRYFGSVCELDLIFNFHKAYYILDEILIAGELQESSKKNVARLIAAQDSLVEAAKEEASSISNIIAQATK