lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Subcellular Localization:
Cytoplasm, perinuclear region.
Sequence:
MTRNRIGALEEDMPPEDELAAHYEAFGTTPPRTRLKIKNRDWERKQKVVNVTASADLPASVGGTPKKTRTARSRVLRRNTMDCALLNEMFVNDESKRTDKRLQSLLRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNSEAMAPIPLRIASKVVESCNRYRCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRKDFHETFANLIKLGSVDRQDAKLSQEEHTWQTELKDLIWLELQAWQADRTVEQQDKYLFEARQGVSDLLTHIINYKFQPRYRREPSLISLDSGTHSDSNSNASSPLPSKMCQGCMSLYCKDCMDHQELALREVEGMLTRLEAAEALYPSSQAMGALHPIYKSQSFVGRIKSMCLWYNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSHMRKGSMHDINIFSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAHIALEKPGAEDFDYESDAESIEEDVPRLDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETRPVRPNPLSLEQLMKELREGLTLALTHRERYQRHITTALVENEAELGSYISILNHYDATVRKTFELYLEYIDQLVLVAVPEGNQKSVLEKEWMFTKLISPMIKGMHTLASQKFCGIISKLLRSISERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICRETQSLLTVERERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFICSDVKAAFKLLQQDVLQVRNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPNTPPLQSPPYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQVRGSFRRNVATSSS
The following text describes a protein:
Function:
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons.
Subcellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized to the cell body, axons and neurites of differentiating neurons.
Domain:
The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
Sequence:
MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCIAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTVSDGTISASKQEGGKMDSKSTAGKAKGKLWLFGKKPKPQSPPLTPTSLFTSSPPNGSQFLTLSIEPVHYCMNEIKTGKPRIPSFRSLKRGWSMKMGPALEDFSHLPPEQRRKKLQQRIDELNRGLQKESDQKEALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGVRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHSEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTTYIDVTLEKNSKGS
The following text describes a protein:
Function:
May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding. May play a role in the regulation of KCNK2-mediated current amplitude (By similarity).
Subcellular Localization:
Membrane; Multi-pass membrane protein.
Sequence:
MEKNSSLWKSLVTEHPLCTTWKQEAEGAIYHLASILFVVGFMGGSGFFGLLYVFSLLGLGFLSSAVWAWVDICAADIFSWNFVLFVICFMQFVHIAYQVHSITFARDFHVLYSSLFKPLGIPLPVFRTIALSSEVVSLEKEHCYAMQGKTSIDRLSVLISGRIRVTVDGEFLHYISPFQFLDSPEWDSLRPTEEGIFQVTLTADTDCRYVSWRRKKLYLLFAQHRYISRLFSVLIGSDIADKLYALNDRVYIGKKHHYDIRLPNYYHMSTPDLSRSPLTEQFRNSRQHCNK
The following text describes a protein:
Function:
May be part of a two-component regulatory system required for formation of conidia on certain growth media.
Subcellular Localization:
Cytoplasm.
Sequence:
MLLNGQISALSLDDNDNGQQHQDEVQAKHQDQGHTCPSRPSVPSLSRIYRCTPVPTIVLDASMVIIEVSNSHVALFGKPRDSLLHTSISDVSPECIPVPNIPILYGALRAACSTREIQVVEHVVVGEKIAHNLRVTPVYEDETLLFVVLEVENLRAEVINNQHAYMNETYKILVDTVKDYAIFMLDPTGHIATWNAGAGVLKGYKAEEIIGKHFSILYSPADRDNGKPARALDVCLREGRIEDEGWRYRRDGSRFWANVLITPIYQFGQHVGFVKVTRDLTERKEAEACMIAAFEESSRLKTDFLANISHEIRTPMNGMQIALTMLTDTGLSEEQREHANIVQDSMSLLLQIVNDVLDYSKLSSGSFSLHADMLDIREIVGAVVRNCRSSLQEGVELDTEISPKLPTRMRGDPLRYRQVLQNLVGNAVKFTEKGSIHVKITSSTDEEDSDSSVVRTEVTDTGIGVPDSAINTLFTPFSRFANSAARKYQGTGLGLSICKSLAELMDGSVGYSPNPNASGSVFWFTAKMGGRSVTPPSKSPSVSGSPVPTEVASEMRSIAPRKHVLLVEDNIVNHTVMLKLLHTIGFQRIDGAWNGAEAVRMVRQKPLSYDIILMDVSMPVLDGLAATEQIRDMGLTMPIIAITGNAMKGDAETYIAQGMDDCICKPVHRDQLLRVLWKWFGT
The following text describes a protein:
Function:
Photorespiratory enzyme that dephosphorylates the 2-phosphoglycolate produced by the RuBisCO oxygenation reaction.
Subcellular Localization:
Plastid, chloroplast.
Sequence:
MAHNHKMDDKTECHHSNKQKHNGHKLPPRHKTRMKFYMYINKNRKLNQKNKRGAKMLTKAAVSISVSASITTAASSKSLICPSHRFLCLRRLSSLRSFSALRIAWRSSNCSYNNKSARTMERFTFTTRASAQPLENADELVDSVETFIFDCDGVIWKGDKLIDGVPETLDMLRSKGKRLVFVTNNSTKSRKQYGKKFETLGLNVTEEEIFASSFAAAAYLKSINFPKDKKVYVIGEDGILKELELAGFQYLGGPDDGGKKIELKPGFLMEHDKDVGAVVVGFDRYFNYYKVQYGTLCVRENPGCLLIATNRDAVTHLTDAQEWAGGGSMVGAICGSTQREPLVVGKPSTFMMDYLANKFGILKSQICMVGDRLDTDILFGQNGGCKTLLVLSGVTSLSMLQSPNNSIQPDFYTNKISDFLSLKAATV
The following text describes a protein:
Function:
Repressor of jasmonate responses.
Subcellular Localization:
Nucleus.
Domain:
The jas domain is required for interaction with COI1.
Sequence:
MSRANTMFDFFAMEKTRSCARGAKLSAISKIDPQLLRRVIASTLPPPSRQLFPSPPPPHPILDPSCRSVATAESDSSSAPLTIFYNGTVSVFDLAQEKAEAVMKLAERTMDYRLLAQLNEELLPIPRKKSLQRFLEKRQQRLTAKAPYTADHEAASAKTTALDALTHPTY
The following text describes a protein:
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
Subcellular Localization:
Nucleus.
Sequence:
MEVDQIPLADVVFVIEGSAINGAYINELKTNYILPTLEHFTTGSIDEREYLIAERFATLYGIVVYRTAANLLEPVCSTYGPFLQPQKVMETIERLPLVGGGMESCAHMAEGFAAAHGCFDDISERRQLLDQTSVQRHCILICNSPPYQMPTTESWKYPGKSCEQLAALFNERKINLSIIAPRKMPVLFKLFMKADGDQPITSKNYAKNIRHLVLLKGYSLKERAPSPNSMAAQMAAPNAAQATVQQQQQQQQNQAGQQQQGQGMPMDTTPAQQQQQQQQQQQQQQQQGNPQQQVMNMNTMQQQQPGPNPPAGLLNPQQQQQLLQQQQQNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQARPPFMQGAGNVGGVGQGGGMQQNPNSALISRINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQRMQMLSQQQMLNHQQLQQQQQLAQQQQQQQQGQQQQQVNPNAGNNMMPASNAGNMSNPQQQQQQVGQQSNPQQQGNPQQQQQGNSQQEQASLREKIWTGVLEWSEKPKSDQQKIPHTLQCTVCTNIKDGEPEIKAENWPPKLLMQLMPKHLVGNIGGQFLKDSKMVVFRPTPGEALDSLAKMMTSGYAGCVHFSSIPNSPACDLKVLILLYTPDRNAFLGFIPNNQAMFVERLRKVIQQKQHGNMQQQQQQQQMMQQQGKSPMELQQQQQQQQQQQQMQQDNSQQQHYNQFQLNMQMGGGGPGGGPGPGPGGMPMQQNQMQMNMMQQQRMPLGVGVGVGVGPGGVPNPNLQQQLQQVAPNVAAMQQQQAQQQQQRMVRPMMSNNNPGLRQLLQHQTTPGNQFRPQMGGQNPNQMGAGGPMVGNRNFDDGNYEFM
The following text describes a protein:
Function:
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
Subcellular Localization:
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Sequence:
MLKNLKSFLLRGNVIDLAVGVVIASAFGAIVTSLVNDIITPLILNPALKAAKVERIAQLSWHGVGYGNFLSAIINFIFVGTALFFIIKGIEKAQKLTGIKKEKTAEKKPTELEVLQEIKALLEKK
The following text describes a protein:
Function:
Prolyl cis/trans isomerase with specificity for phospho-Ser-Pro bonds.
Sequence:
MRKSFLLIYHQLTKQVSTEQTFFHCLSFSFCLSLNSTRRISRTLRMKPDALIKRKWSCSSSSYEEVTSKRAKESPLPSPDKEQSGRRSNNKEMLAVEKVTACHILVKHSESRRKASWKDPEGVEIKKTPRHIALEKLTGARKEIVDRKKKFEDVARKLSDCSSAKRGGSLGSFGRGKMQKSFEEVVFALKVGEISEIVNTDSGFHIILRTA
The following text describes a protein:
Function:
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
Subcellular Localization:
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Sequence:
MSSFQSATTRQGLHRRNMNSETPQSEFIQRLRRSPPSESSSSTPSSSTTTSSTTTTSNTSGKKKKTAPSASDFYVPSLPGQPKDSQLILYAGHLSFSPPDTTIEPEKDSYGFFFLNKARHIANRPVLLVWLNGGPGCSSFDGSLMEVGPLRMVLKGDGTLKEVDAAWNEYANMLFIDQPTGTGYSYGPKPNYVHELDVSSANLVNLLARFFKIFPEYQQMDLYICGESFAGQYIPYLAQAILDTNIISAPLKGIMIGNGWIDPINQYLAYPEFAFKVGLVNPSSKAADLVNEELKKCTEWIDSNSTTPIHIEACEGILSAITDSTVQTVNSQKMCLNMYDVRLVDSYPACGLTWPPDLADITPYLSRTDVKQALHAQDHAADWVECEAKVGNNFWAKTSQPSVTLFPKLLDKIKILLFSGDQDLICCHTGTERMIDHLTWAGHQGWTSQAINQPWKVNGSYAGLWKEERNLTYVLVANASHMAPYDVPYVTQDMLVRFLGIDVMTAAGPAAQITSRIGEETATKVNRVVMNETKLGQEGSGTTGLAMTSGPVHDENYYNASSAMLFLTLVGLVVGLIFFVRRRLRRDGHGDFAHHPSDETEIILKNHHHHHLSPDSSLPRSARDRQFQPVPTDDLDDHHLHPNLPSNNTSYQDLPR
The following text describes a protein:
Function:
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Sequence:
MRMGRARLASQRHRVRIAALQILFEVDETDHAIDQVLERRLTDEPMSQESAEFLRRLVFGAWEHRSYLDRIIEEAAPNWPVAQMPGVDKAVLRIALFELLIDDVERTPIKAVINEAVELAKQFGSDNSSRFVNGVLGTVVTRYLADRDDTVEE
The following text describes a protein:
Function:
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular Localization:
Cytoplasm.
Sequence:
MDFDPTSIDFSSFPLLKDTKLPSLVENLHSGARSFVIAKLFKELKRSIVVITTLAKLDDLFEDLTTLLAESPLEFPASEIDLSPKLVNGDAVGKRDHILYSLQKQSAPVICVTTLKALSERTPSPESMIRDHLELRVGEELDPDTLLDLCKSLGYRHEALAREKGDFAFRGGIVDIFPLSSPEPFRIEFWGDRVSSIRSYNPSDQLSTGKLSQITISPATAIIPTNKLSHSLLDYFKAFPLCIFDGLSSLEDNFSDIAGILASLPKRFMPIQDLCQRILKEFTPLFFEEKTFPNLISHKDTGFSIEAFHKKISVQRVSLPFIYPPALIETSGEQNPLLAFLKTFQDFCAGRTLSLALYCSNTKSLKEAHDLAAACIPNTQIYDHPTTLSSSFALVEAGFAAVSLSEFAASKVLRRQKQRNYFSTTTEEVYIPVPGETVVHLHNGIGKFIGIEKKPNHLNIETDYLVLEYADKARLYVPSDQAYLISRYVGASEKAPDLHHLNGAKWRRSRELSEKSVILYAEKLIQMEAQRSTANSFIYPPHGEEVIKFAESFPYEETPDQLKAIDQIYADMMSDKLMDRLICGDAGFGKTEIIMRAAVKAVCDGHKQVIVMVPTTILANQHFETFSQRMAGLPITIGLLSRFSQGKTMKKTLEDIAQGRIDILIGTHKVINKAIEFHNPGLLIIDEEQRFGVKAKDSLKERFPTIDCLTVSATPIPRTLYLSLSGARDLSLITMPPLDRLPVSTFVMEHSEETLSAAIRHELLRGGQVYVIHNRIESIFRLGETIRTLIPEARIGVAHGQMHANELASIFYKFKTQQTNVLVATALIENGIDIPNANTILIDHADKFGMADLYQMKGRVGRWNKKAYCYFLVPHLDRLSGPTSKRLEALNKQEYGGGMKIALHDLEIRGAGNILGTDQSGHISAVGFNLYCKLLKKAVAALKHKQKPMLFHDDIKIEFPYHARIPEDYIDLASMRIEFYQKIGNAESEEELEAIEEELRDRFGPSPEAISWLFALARIRLIAQEYHLSSIKGTGNALYIQQYHDKDKQIQKTLPYSLSPTPELLVKEVQESVEKAFPK
The following text describes a protein:
Function:
Acts as a negative regulator of abscisic acid (ABA) response.
Subcellular Localization:
Nucleus.
Sequence:
MEKTRKKLRNVKLNLGRSLNGNFGVNSKKLKILNCSSSITNENSSLLFSHGLQGSVASSLTELETQQPPNRWKSAKEVGEKLRKFLYKMPFVFYDGPNGKKTKAYLLYSFTKREDLKIVCACHADFLTPAQFVKHGGGVDVENPLNHIEIILDY
The following text describes a protein:
Function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Subcellular Localization:
Cytoplasm.
Sequence:
MNLKQALIDNDSIRLGLEANNWKEAVKVAVDPLIESGAILPEYYDAIIESTEEYGPYYILMPGMAMPHARPEAGVQSDAFSLITLQNPVVFSDGKEVSVLLALAATSSKIHTSVAIPQIIALFELEDSIARLQACQTKEDVLAMIEESKDSPYLEGLDLES
The following text describes a protein:
Function:
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
Subcellular Localization:
Nucleus.
Sequence:
MLHLSEFSGPDALLVKSTEGCCSEPSTDLTRLPARDPPAATGYPAAGDFLSWALSSCGAGEYLTDSCLLEGPAPTPPPGLGYSGSFFIQAVPEHPHDPEALFNLMSGILGLTPFPGAEAAASRSPLDASFPAGSDALLPGPPDLFSPDPGAAAFPEAFWEASPSAGAPSQCLYEPHLSAPDVKPGLRAPPASPALDTASAFKGPYSPWELLSAGAPGSCGSQGGYQAAPEARFPTTGAKIEDLLSISCPAELPGGPASRLYTMGTYDAFPLAPGDLGEGAESLPGLLTPPSGEGGSSGEGGEFLDGTQPELSPLGLRSATADFPKPLVADIPGSSAVPEPPVPPPAPFPPAKARRKGRRGGKCSARCFCPRPHAKAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGLSFAAL
The following text describes a protein:
Function:
May negatively regulate the basal and activated transcription of many genes.
Subcellular Localization:
Nucleus.
Sequence:
MLKTQEIYSSEDEDDMCCPLCMEEIDISDKNFKPCQCGYRVCRFCWHHIKEDLNGRCPACRRLYTEENVQWRPVTAEEWKMDLHRKNERKKREKERKEVELSNRKHLANIRVVQKNLAYVNGLSPKVANEENINVLKGPEYFGQYGKIIKIAINKKAAANSANGHVGVYITYQRKEDAARAIAAIDGSVSDGRHLRASYGTTKYCTSYLRNQQCPNPSCMYLHEPGDEVDSYTKEDLASLQHTRPLSTKPNVVNGATHSPSPSLPFKTPLLPVTKTPLEEANSSPAAQNQHITTVDHVHPQVSMTPSLSTNNTATSVPAPYSSAASVNVVPGHATTILHHEESSALPPTAAWAKLSPSVLQERLRAAVNQQPLDALKSSSTQTSIPKIQKLKAAKLPSEEENTTKWLNKAINDLVSSLSKINFSTEGTEFDKKQIEMIQNLPPLFVFNARSVIDKEVVPEQEKSAENQPPTSLGINNGNPVMPPPGFQS
The following text describes a protein:
Function:
Radical S-adenosylmethionine (SAM) enzyme responsible for the first step of the biosynthesis of the enzyme cofactor mycofactocin (MFT). Catalyzes two reactions at the C-terminus of the mycofactocin precursor (the MftA peptide). The first one is the oxidative decarboxylation of the C-terminal L-tyrosine of MftA, forming an unsaturated tyramine moiety. The second reaction is the cross-linking of the tyramine with the penultimate L-valine residue, forming a five-membered lactam ring. Its activity requires the presence of the MftB chaperone.
Sequence:
MTSPVPRLIEQFERGLDAPICLTWELTYACNLACVHCLSSSGKRDPGELSTRQCKDIIDELERMQVFYVNIGGGEPTVRPDFWELVDYATAHHVGVKFSTNGVRITPEVATRLAATDYVDVQISLDGATAEVNDAIRGTGSFDMAVRALQNLAAAGFAGVKISVVITRRNVAQLDEFATLASRYGATLRITRLRPSGRGTDVWADLHPTADQQVQLYDWLVSKGERVLTGDSFFHLAPLGQSGALAGLNMCGAGRVVCLIDPVGDVYACPFAIHDHFLAGNVLSDGGFQNVWKNSSLFRELREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPLDGPDPECVQGHSEPALARERHLPRPRADHSRGRRVSKPVPLTLSMRPPKRPCNESPV
The following text describes a protein:
Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.
Miscellaneous:
MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
Subcellular Localization:
Cytoplasm. Endosome. Late endosome membrane; Peripheral membrane protein.
Domain:
The UEV domain is required for the interaction of the complex with ubiquitin.
Sequence:
MSANGKISVPEAVVNWLFKVIQPIYNDGRTTFHDSLALLDNFHSLRPRTRVFTHSDGTPQLLLSIYGTISTGEDGSSPHSIPVIMWVPSMYPVKPPFISINLENFDMNTISSSLPIQEYIDSNGWIALPILHCWDPAAMNLIMVVQELMSLLHEPPQDQAPSLPPKPNTQLQQEQNTPPLPPKPKSPHLKPPLPPPPPPQPASNALDLMDMDNTDISPTNHHEMLQNLQTVVNELYREDVDYVADKILTRQTVMQESIARFHEIIAIDKNHLRAVEQAIEQTMHSLNAQIDVLTANRAKVQQFSSTSHVDDEDVNSIAVAKTDGLNQLYNLVAQDYALTDTIECLSRMLHRGTIPLDTFVKQGRELARQQFLVRWHIQRITSPLS
The following text describes a protein:
Function:
Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibition of processing of pre-PrcB and assembly of the proteasome complex, and thereby enhances the mycobacterial resistance to H(2)O(2); PknA thus plays an important role in the oxidative stress response by impeding the formation of holo-proteasome in M.tuberculosis under H(2)O(2) stress. Shows a strong preference for Thr versus Ser as the phosphoacceptor.
Miscellaneous:
MISCELLANEOUS: Overexpression causes major growth and morphological changes that indicate defects in cell wall synthesis and possibly in cell division.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Note=The majority of the cells displays PknA expression at the membrane perimeter along the length of the cell, whereas a minor population shows PknA to localize at either or both poles (uni- and bipolar; 16 and 14%, respectively) and occasionally to both the poles and the midcell (12%).
Domain:
The extracellular domain is dispensable for cell growth and survival in vitro. The catalytic activity of PknA is confined within the N-terminal 283 amino acids.
Sequence:
MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSRPATGGHRPPRRTFSSGQRALLWAAGVLGALAIIIAVLLVIKAPGDNSPQQAPTPTVTTTGNPPASNTGGTDASPRLNWTERGETRHSGLQSWVVPPTPHSRASLARYEIAQ
The following text describes a protein:
Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular Localization:
Mitochondrion inner membrane; Single-pass membrane protein.
Sequence:
MMPSKFYKRSLSTRNEDNYNQQTIFKHPQINLTPIKKRVNLTRIDGYENIISQLYTPRQIKNIGYSPKIIKHSAYQEETQFNNIVQGYFLPTPRKISLQFNKIITEPTTFNNSPIRKQEKNCIILKNTKTDLEYDLDKQLNIPQKIRLYFSCQKLQKRFFKLQELLQFISIKSMYQYLNDQNSNTIDYVAEFDIQYKQFILTEFLCIILYFLIKYNLIKKDELSRLEKLILYQHQQNACNVIHKLQIHVPGFKTYMHLFYQLQQANPLIPKQIDLLNKYIDKTIDDLIKTIVNYQLKQQIREFLFMKIEQKTSDFIDKLKKIIESIQENLYFLPKNEKEYTLILDLEETLIHIDDKSQIKKRPFLQEFLEELSRYYEIVVFGHLPQLEMEKIIPIIDENSIIKHQLNRNHLMKYEKVLIKDLTLLGRPPNKYIIVDNDPFNFLLSPQNGIQIRSWHGEQGDHALQDLQPFLGDLRLYKDVRIGLTQVKTYSQYFFVPL
The following text describes a protein:
Function:
Converts sphingomyelin to ceramide.
Subcellular Localization:
Secreted.
Sequence:
MKIINIILLFLIINLAYCHNSINKQNNNKNDININQYNNIDINNIDDKVLLKRLGYDTNGTKCDVCTYGINEIQKMIITEKGPEDIKAWAIDLCTYLRIEKPQVCEGLIPLFMGMAKNVLSFPGVNGEFVCGYVGFCPYKPSNYTPEVIFPKPKPPHVPVVPPSPGSPTMKILHLSDIHVDPIYEQGMNADCGEPLCCRAVNGPGKGSNAAGKWGHYSCDVNLLMVGSMFEFIENEFGNEIDMVFWTGDNPPHDIWEQTFDGQLNSSLLVTNLVKKYFGSSKIFPAIGNHESLPVNSFPLPPGSSWLFNALASDWSDWINTDEQVKTLQWGGYYTLPVQNGIRVVSLNMNWCNNGNLWMVENGTTDAAGMLQWVIETLQASEDIGEKVYLVGHIPPGIADCVDIWSEQFFQIVNRYEDTIIASFYGHTHRDEFEIYYTQDENNPNQTRPSSVVYVTPSVTTYQHQNPSFRIYTVDAQTGYVMESSTYHTDLSQANLNDKPTWLLEYNATKAYNMPDLTPTSWHHAVSNMTADSSLFEKYYNYYYSSSPYPESKPCTSDSCKLDFICKMSSATYLKYYECVHQKITEHLSNEPNDQLKVSRKVNILLDLQNYLNNDTLKSC
The following text describes a protein:
Function:
Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Prevents the accumulation of intracellular nicotinamide, a known inhibitor of poly(ADP-ribose) polymerases (PARP enzymes).
Sequence:
MANHETIFDQLKKQIPVDEEEPLILNRDSSVGLVIVDVVNGFCTIGSGNMAPTKHNEQISKMVEESAKLAREFCDRKWPVLAFIDSHHPDIPERPYPPHCIIGTEESELVPALKWLESEDCATLRRKDCINGFVGSMESDGSNVFVDWVKEKQIKVIVVVGICTDICVFDFVATALSARNHGVLSPVEDVVVYSRGCATFDLPLHVAKDIKGAQAHPQELMHHVGLYMAKGRGAQVVSKISFET
The following text describes a protein:
Function:
May play a role in regulating breast cancer cell invasiveness. May be involved in RYBP-mediated breast cancer progression.
Sequence:
MSSTVNNGAASMQSTPDAANGFPQPSSSSGTWPRAEEELRAAEPGLVKRAHREILDHERKRRVELKCMELQEMMEEQGYSEEEIRQKVGTFRQMLMEKEGVLTREDRPGGHIVAETPRLTEGAEPGLEYAPFDDDDGPVDCDCPASCYRGHRGYRTKHWSSSSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKKKSVKKHRRDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSRSYSPIRKRRRDSPSFMEPRRITSAASVLFHTTGPAPLPPPAA
The following text describes a protein:
Function:
Virulence factor that modulates host innate immune response. Induces the production of the pro-inflammatory cytokines IL-6 and IL-12p40 in macrophages via NF-kappa-B, ERK1/2 and p38 signaling axis. Can enhance M.smegmatis survival within macrophages and under stresses such as H(2)O(2), SDS, diamide exposure and low pH condition. Promotes the death of macrophage by apoptosis in the later stage of infection.
Subcellular Localization:
Secreted, cell wall. Cell surface.
Sequence:
MDFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVEVSTAASSVGSVITRLSTEHWMGPASLSMAAAVQPYLVWLTCTAESSALAAAQAMASAAAFETAFALTVPPAEVVANRALLAELTATNILGQNVSAIAATEARYGEMWAQDASAMYGYAAASAVAARLNPLTRPSHITNPAGLAHQAAAVGQAGASAFARQVGLSHLISDVADAVLSFASPVMSAADTGLEAVRQFLNLDVPLFVESAFHGLGGVADFATAAIGNMTLLADAMGTVGGAAPGGGAAAAVAHAVAPAGVGGTALTADLGNASVVGRLSVPASWSTAAPATAAGAALDGTGWAVPEEDGPIAVMPPAPGMVVAANSVGADSGPRYGVKPIVMPKHGLF
The following text describes a protein:
Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular Localization:
Nucleus. Plastid, chloroplast.
Sequence:
MADGAEDPRRGPLDTGTERYQKLKQTQVPRDEQEVPLEYQKLVEPHVASFNYFIGEGLQNVVESLQPVEVTHPTTGLVTRIWLSDVRVEKPVRDDVVGLRLGGGGGGASVANSRIMPRDCREGGTSYKGNLMATFNWCEGDGERCCIDRKLGGLPIMVRSDACNLSGMSRAELVAAKEEANEMGGYFICNGIERIIRCLVAQRRHYIMALRRGAYHKRGANYTDAATLIRCVRPDQSSATVRCHYLTDGTVNFAFTMRRAEYFIPAGVLLKCFLEVSDRELYGKLVSGSAPGGGAAAFAAERAELLLRQADRHDLRTKTQCIEYLGRHFRVVLEQPPSATDYEVGEALLAEYVFIHLDPARPADKLNLLVAMLHKLYALVCGACAEDNPDALTHHEILLPGHLLLKFMKEKLEDTLSITRELMKKDLEARPGTDVASAEYMAGLLKKLGDVGSKFEYLLNTGNLVSRSGLDLSQATGFTVVAEKLNFFRYLSHFRSVHRGAYFAELRTTTVRKLLPESWGFMCPVHTPDGAPCGLLNHFTAACSIVTQGSSNEELTSLGIMQVLTALGMSPAAPALSPPPPPDYLCVQLDGRVVGHVRSGAAAAALVARLRAIKASALEAYERGVPAEGVGLGAAEAEVPYHLEVVHVPPLLGGPFPGVFLFSQSARMIRPVVQLDSSKREMLGSLEQCFMSIRCPDGGHGGSPGLAFTHAELGAGAMLSVVASLTPYSDFNQSPRNMYQCQVTLIGTGGGRGGGGGELPQQANIRLRFNRNPMIGDKFASRHGQKGVLSILWPDTDMPFCAATGIRPDLIINPHAFPSRMTIGMLVESLVSKGGALAGQFVDASPFQRADGVEKGNATERWGAYLERQGFSRYGQETMISGVTGQEMPCDIYIGPVYYQRLRHMVSDKFQVRSTGPINAMTRQPIKGRKFGGGIRFGEMERDSLLAHGAAYLLHDRLHACSDYHVADVCVSCGSLLAPLRKPAANADVTSNLMLGGGGGEGGGKTVCPVCCPGSSATIERVALPYVFRFLAAELAAMNIKMELEIK
The following text describes a protein:
Function:
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Subcellular Localization:
Cytoplasm. Nucleus.
Sequence:
MMGFIAPIQPPQAPVRWQKEDTIAFVEKQDLSKGTLYIAESHVAWINPSGQGFNIPYRAITVHAISRDLSSFPHECLYLMIDSDVNNSDDGFEEEEGNEVREIRLVPQDKTMLQSMFEAMSQCQALHPDPDESDNSDPYDQGDEDEEVGEEEGGEEDPEIGIELIVADGGNGDAMDTGQFDDADMGPEH