lhallee/plat_data huggingface dataset:
The following text describes a protein:
Function:
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Sequence:
MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNQESDRFLHIMQQHPEMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVNSNDMMS
The following text describes a protein:
Function:
Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
Subcellular Localization:
Cell inner membrane; Multi-pass membrane protein.
Sequence:
MIVNFISALGKQVIDFFRALGRAGFMLFGALIGKPQIRKHFPLLVKQMHVLGVQSLLIILLSGLFIGMVLGLQGYVVLIDFSAETSLGQLVALSLLRELGPVVTALLFAGRAGSALTAEIGLMKATEQLSSLEMMAVDPLRRVIAPRFWAGVISMPVLSILFIAIGIWGGSLVGVDWKGVDSGSFWSVMQNSVSWSYDILNGFIKAVFFAVAVTWIALFNGYDCMPTSEGISQATTRTVVHASLVVLGLDFILTAIMFGAG
The following text describes a protein:
Function:
Protein transport. Probably involved in vesicular traffic (By similarity).
Subcellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side.
Sequence:
MESMDAKIVLLGAQGVGKTCFVTRYVNNKFQAGQASTIGASFSRKRVVVNDTTVRLQIWDTAGQERFRSMAPIYYRSASCGILCYDVTSRASFDAMHLWLLELKQNLSSDIIIHIVGTKVDLVKDEPSLREVPFEQCVEYASEWLQDDSCCHEISAKDDEGVEEVFEVIITKLLDKREADEQQKHNSQRQRQSVVYLHTDEDEQKSSCC
The following text describes a protein:
Function:
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
Subcellular Localization:
Cytoplasm.
Sequence:
MPRPMLGVMSPTSAVTPPPAVPPSPAQTLRDVRLSDRVRLVRNVLPPLIVLVVIVVELLITQLPNRHAELVAHLLFYGLVGPAVTFFSVEWIAQGTRARERAERELRELYIELSTSNGQLRAVQELMRDLADAPDLAAVVEVAVRGAVRVTGATHATLSVPGGLSATARGDTLLSGPSADLHPLRRPIPGGGAMTLHFQGPPTPHTVALVEALAGEIANGVEAARQRTLDLMTLFNVDQSIRAERNMRRLLSRVTRNMAERLGADARAAYLFDQDGVLRLEYAQDFAGREEVGGSPAPAFALRVAQEGTPLQAEGEEAAGVFSHAASVLGLPMRDDQGPVGVLVLGDARADAFEGARVPLLAFMAGQATLAVRNARAYLYSEELAISDERARIAREIHDGVAQSLAFAAIKLDLVGRKLRSDPDKSEADVKEASALLREQIREVRRSIFALRPVDLERYGLLETVRRYVADFGEQNGVRTNLDLTGDIHLSPGDEAVVFRILQESLNNVAKHARAREVTVSLHGGANRVTLRVQDDGQGFDPDAVSGRVSSAGGLGLMQMQERLEARGGSYRILSAPGHGTVVEAQLPQL
The following text describes a protein:
Function:
Required for G1/S transition. Plays a role in DNA replication checkpoint signaling through regulating rad3 and cds1. Involved in the maintenance of mitotic chromosome structures during S phase through regulating the function of rad21. Required for initiation of mitotic DNA replication through phosphorylating mcm2/cdc19. Required for genome integrity.
Subcellular Localization:
Nucleus. Note=Nuclear throughout the cell cycle.
Sequence:
MAEAHITLSPKVTHEQQTDIDSECEITEVDDENVNENKSQEMIQDIPARDREEIENITRTFVELQENYRLIEKIGEGTFSSVYKAEDLHYGRYINDWDIQSEVLKESSFGKEKIPVNEDSRKPKYVAIKKIYATSSPARIYNELEILYLLRGSSVIAPLITALRNEDQVLVVLPYYEHTDFRQYYSTFSYRDMSIYFRCLFQAMQQTQTLGIIHRDIKPSNFLFDVRTKHGVLVDFGLAERYDGRQQSHSCRCTNSNAAELAHDFSIAQETSLGYIKNDTRPSKRANRAGTRGFRAPEVLFKCSSQSPKVDIWSAGVILLSFLTKRFPMFNSKDDVDALMEIACIFGKSEMRQCAALHGCTFETNVSTLTEKRVNFRKLILWASCGSASIYKEKLRHKPSQEERLCLDFLEKCLELDCNKRISAEEALDHDFLYLDNLAYEKKDDDTAFDNSFGETSFEKDEDLTAKHLSHILDFKEQEETDEPTSLSKRKRSIDEILPNDALQDGA
The following text describes a protein:
Function:
Transcription factor that activates the nmt1 promoter. Regulation of thiamine repressible genes. Negatively regulates conjugation during meiosis, by inducing negative regulators which delay conjugation. Involved in thi1 regulation.
Subcellular Localization:
Nucleus.
Sequence:
MCPSDFSSRSLFLEAKEEEYKQRRRVPLDSRRRVRRACLSCRAKKIRCSGSEPCQACIATPSQCKYADSLKERTPSKQFIAELSQRQKCFEYLMELLCPSLPHDTRSLVKLCKHVESSLASGSDVRSLLIPGSIDQSVLKVAATNNKDDSSAVKSANVSFPSSSTPPSSDSNFSSIQNTDLNTSIKFTENISANAIHVNQDKVIRSANNLIINSQPILPVRSFLDALGEPIYLSPTSSTYFLNSVLASLQLNSSNTPESLLIDYQSKIPEDLSSSLLPLELNTLQSTPTSVSVGSASSQGTHEYSIINLTSNHSSFSLKALKKIAHNLLPPVSVAERYANEFFLRYQSFFYFYPPSVFSNRYQILADGLVNSDTLDTGFLAVALLIVVLGHFSNNNINVLPKEVQLSHIDSMIQISEQLISSLLNRCTLSSIQAVFLLSLYHFLTGNFKCAYSYLGFAIHSAHTLGLEHGSTDNSTLNEVSTEETSIRICWSLRVLASFLYIQSGITPIINLFPNGLNSLKLPTVVPELEARHLPSSVFHFVAIIKYAEISVRSLNSLYESSSDYLMDVSNFPKLLLKVERIYSQARNWKLNLTHQQLNGTNDTSDLLFHSNVSLHLFYHYLIVKVSCPIMFFYLNNWYSVKPSSFTKGLNNKPSLEDVFSNLETCYESAKAIVQLSSKLLSAGQMDKCFYLEFEILYCSAIVLFLFSVMHLGAENPLLESIYLLEDMGSRTIDSKVRLEKLKSAIEIFDINSATEMPINEPLSASFESVNKENSQSGYMAWQNWVTELSSSNIPLGHALGNPESNNSSNSFKPSHPSQSFLVNESLDFSSNPKEPPFLPWSEALLNMDMQLNRLGP
The following text describes a protein:
Function:
Involved in resistance to abiotic stress.
Subcellular Localization:
Cell membrane; Single-pass membrane protein. Cytoplasm.
Sequence:
MSQYSQNQSSGAYPTPPVSTGPYMTPPPLGYPTSDISHATVAPVETKSKGDGFLKGCLAAMCCCCVLDACF
The following text describes a protein:
Function:
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular Localization:
Cytoplasm.
Sequence:
MRNMNKKIIKADKLVGEVTPPPSKSVLHRYIIASSLAKGISKIENISYSDDIIATIEAMKKLGANIEKKDNYLLIDGSKTFDKEYLNNDSEIDCNESGSTLRFLFPLSIVKENKILFKGKGKLFKRPLSPYFENFDKYQIKCSSINENKILLDGELKSGVYEIDGNISSQFITGLLFSLPLLNGNSKIIIKGKLESSSYIDITLDCLNKFGINIINNSYKEFIIEGNQTYKSGNYQVEADYSQVAFFLVANSIGSNIKINGLNVNSLQGDKKIIDFISEIDNWTKNEKLILDGSETPDIIPILSLKACISKKEIEIVNIARLRIKESDRLSATVQELSKLGFDLIEKEDSILINSRKNFNEISNNSPISLSSHSDHRIAMTVAIASTCYEGEIILDNLDCVKKSYPNFWEVFLSLGGKIYEYLG
The following text describes a protein:
Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.
Subcellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Sequence:
MLTKFEARSSRVKAVALHNSTTWVLCGLHNGAVQIWDYRMSTCVDTYTEHVGAVRGADFHVNQPLFVTGGDDYTVKVWNYKLRRCLFTMTGHMDYVRTTFFHHEQPWIVSCSDDFTIRIWNWQSRKSIACLPGHNHYVMCAQFHPFSDLVVSGSLDKTIRVWDISALRHRKEEVGITHDLLGTTDVVVRYELEGHEKGINWVAFHACGDLLLSAADDRTVRLWTMSGTSCYVSRTFTGHTSNVCCAVFYRNDYLISCAEDRTVRVVHMSSGVTVQTFRREVERYWIMASDSTRNLIAIGHDAGLQVFKLTRERPAFAIHSATQLYYTCQNKLHMYNFETEEVTSCTVTYQFNPPTALSCCPTTGGVMLSYANGGPQIEWIPKPLATRTCNVEATLKGIDGVFFGGHKLAYVDVSGKMCIQNVAKASGKPQQTDVSCSRIFPGPVGCVLCQSNDKILLYQVAQQGAVAEATVSGVRYAVWDKDFSKVALIAKNTVTIMTKRLKIIASVAESSARIKSAAFDETRDVMYFTTSNHLKYCYLRSGETSTISTLKNVVYLVRAVGDSIYVLTRDGRVLRKELDNVELNFKLNLQQQSYRDLIRIVQQGKLKGQALVGYLHKHGHSEIALHFVSDSLTRFNLAIECGAIDIAKATATELNQPAIWRRLADTATSFGDIQLAQFASAKAGNYYASGLLALLTGNIASVANLVNATRDDNFKLHYSMYMDDARQRVDILCKVNQLPLAYVTAKSNGLEEMAAQVLQRMEPEVAARVQAQRFHPAPQKPAVEPATENWPMLQVEESVFARLLKEPGQLDIIAQPELDEDVAAGAGWDDDEDDNTLLASAGAGAGDAGALTTKDEMDGGWDDDLDIDVSAALPGAGGATSAGSGYVVPREHPTIMQTWVDAYTLPAFHVAAGSFASALRLLQRQIGLADPTPLKPYMLQLWAAVNVCRPAPNGLRAVFAMSTPPPDSETEARHAPALPDFMPVLAEKLRVGYQLFVEGKFSEALDVFRSILHLSVVTVVKDDQQKAMLREIMAIAPEYTRALALQLQLRTLNAFSAESLQLALYFTHFRLHRAHLTLALSQAMSKAYKQKNIKTAAEVARRLLEQDPPQNKAQQAAAIIAEADRNPTNAIEIEYDERNPFTICSATYKPMYKGVVSPVRCSYCFSPANPSCKGTLCPVCKLAKIGVDSAGLVNRI
The following text describes a protein:
Function:
Aerial growth, conidiation, and dispersal of filamentous fungi in the environment rely upon a capability of their secreting small amphipathic proteins called hydrophobins (HPBs) with low sequence identity. Class I can self-assemble into an outermost layer of rodlet bundles on aerial cell surfaces, conferring cellular hydrophobicity that supports fungal growth, development and dispersal; whereas Class II form highly ordered films at water-air interfaces through intermolecular interactions but contribute nothing to the rodlet structure (Probable). TH1 is a class II hydrophobin that reduces water surface tension dramatically upon assembly at the water-air interface and plays a role in the formation of aerial hyphae.
Subcellular Localization:
Secreted, cell wall. Secreted.
Sequence:
MKFLAAASLLVASTLAVPTSSGGSCRPRPPPGGGNGGNGGNGGNGGNGYQPCPAGLYSNPQCCATDVLGVADLDCKNPSSAPMSGDNFKSICNAVGQQAKCCVLPVAGQAVLCQDSINGGGNGGNNGGNGGNNGGNGGNNGGNTDYPGGNGGNNGGNNGGNNGGNNGGNNGGNNGGNNGGNNGGNNGGNNGGNGGNGGNGYQACPAGLLYSNPQCCSTGVLGVADLDCKNPSSAPTSGDDFQKICANGGQQAQCCSIPVAGQAVLCQPAIGGGNPGGNGGNNGGNGGNGGNNGGNNGGNGDYPGGNGGNNGGSNGGGNGGNGGNGGSFKCPSGLYSVPQCCATDVLGVADLDCGNPSRQPTDSSDFASVCAAKGQRARCCVLPLLGQAVLCTGA
The following text describes a protein:
Function:
Catalyzes the attachment of glycine to tRNA(Gly).
Subcellular Localization:
Cytoplasm.
Sequence:
MAEDLFEKLVEIGKRRGFFWPSYEIYGGVAGFYDWGPLGHLLKRRIIEKWRRYFVLMHQDHVVEIETPVIGPEKVYIASGHVEHFTDPIVRCTSCGRTFRADHLVEEALGINAEGLSVSELDRIIRERGLRCPVCQGELGRVETFNLLFRTQIGPYEGSVGYLRPELAQGIFVAFKRVYEAMRSRIPLGIAQVGRVGRNEISPRQALVRLREFTIMEMEYFIDPEDQWGSCPFFHRMADSKLPILTYEAKRRGEEKPESFKLEEAVNEGVVISPCLGYWMAVGMRFVEDLGVPSDSIMFEEKGPEERAHYSSQTFDQLVKVSRWGWIEVAGHSYRGDYDLSRHMKYSGQDLTAFKPYPKPIVVKKRRVVVDKAAIGRALKSRAKTVLEELGRMGEGELERLAASNRAVVAGVELPPGSLRIVEVEEKVSGRRFVPHVVEPSFGTDRNVYVALEYAYREVEGRVVLAFPRDIAPVQAVVLPLVENDEKLVERARMVYETLVEAGFTVYYDDSGSIGRRYARADEIGVPAAVTIDYQTLEDGTVTLRDRDTWRQVRIGADEVVDKLRRFIYDGARLEDLGTPVKP
The following text describes a protein:
Function:
Core component of the survival motor neuron (SMN) complex that plays an essential role in spliceosomal small nuclear ribonucleoprotein (snRNP) assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non-target RNAs of Sm proteins. A major component of nuclear bodies known as gems (gemini of Cajal bodies) thought to be storage depots of excess SMN complexes. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. However, Smn is required in motor neurons, but not in cholinergic neurons, for normal motor behavior but plays no role in synaptic transmission according to a report. In both muscle and neurons, required for the formation of a normal neuromuscular junction (NMJ) structure. Plays a neuron-specific role in long-term homeostatic compensation at the larval NMJ. In the thorax of adult flies, required for Act88F, an indirect flight muscle (IFM)-specific actin, expression and for proper IFM myofibril formation. In nurse cells, oocytes and follicle cells, required to maintain normal organization of nuclear compartments including chromosomes, nucleoli, Cajal bodies, histone locus bodies and heterochromatin. Required for the functional integrity of the cytoplasmic U snRNP body (U body) and P body. Required in dividing postembryonic neuroblasts (pNBs) for the correct basal localization of mira. The tight regulation of its expression is critical for stem cell division, proliferation and differentiation in male germline and developing central nervous system (CNS). Required for tracheal terminal cell lumen formation.
Subcellular Localization:
Cytoplasm. Nucleus. Cytoplasm, U-body. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, Z line. Note=High expression detected in the cytoplasm of female germline stem cells and cystoblast which persists up to stage 10 egg chambers. Accumulates in the cytoplasm of dividing pNBs. Colocalizes with Actn at the Z-line of IFMs. Expression concentrates at the post-synaptic region of NMJs in larval brain. Component of nuclear gem (Gemini of Cajal bodies) structures that partially colocalize with or closely appose Cajal bodies.
Sequence:
MSDETNAAVWDDSLLVKTYDESVGLAREALARRLADSTNKREEENAAAAEEEAGEISATGGATSPEPVSFKVGDYARATYVDGVDYEGAVVSINEEKGTCVLRYLGYENEQEVLLVDLLPSWGKRVRREQFLIAKKDEDEQLSRPKASAGSHSKTPKSSRRSRISGGLVMPPMPPVPPMIVGQGDGAEQDFVAMLTAWYMSGYYTGLYQGKKEASTTSGKKKTPKK
The following text describes a protein:
Function:
Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity).
Subcellular Localization:
Cell membrane; Multi-pass membrane protein.
Sequence:
MGPGWRAPSAALVGGSVALFGALRRAALALPRPAAVRSRPGRVWRWRNLLVSFAHSVLAGLWALFSLWQSPELLSDIQDGYSVSGHLLVCFSSGYFIHDSLDIIFNQQSRSSWEYLVHHAMAISAFVSLIITGRFLVAAMLLLLVEVSNIFLTIRMLLKMSNVPSPALYEANKYVNLVMYFAFRLAPQVYLTWYFVRYVEVQGQGAFLMANLLLLDAMILMYFSRLLRSDFFPSLRKGSVGRDVDGEKFLID
The following text describes a protein:
Function:
Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.
Subcellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome.
Sequence:
MLLATSAAPPVPPVGSPLSDGEYQLFFSSLWPIWKAHASCHLRQTFGCLSPAVLRLDEQENHGRVPEGPVCSAFPEAPWFQTFCQFAQYRCSKRKFYVKVSSGTGAMKEKEGEGRGGEGRGGEGRGGEGRGGEGRGGEGRGGEGRGGEGRGGKGREGKGREGKGREGKGREGKGREGKGREGKGREGKGREGKGREKSSYFSLFHSANPMSEFFSKRPSSSRGRDLTSFIHFSASLLALTRKEAVMILCYAVLEGVCVSSVVTQAWKELEEKVLGFGDSVCDSLGRRHMNLCPACAFCSLKVEQCQNIYHLRRVHCKTGSFITYINPQISTQHRAAGNKVLKPSKYFGTQVYRGLRPEYWCSLIATQGCDDPRVMLWLQAEYATFRAGDVPSKICDSSGVQHPTYCAFKSHQCLQHSLYNQRVIRHGCFTNQTYHVLSEEEGKEEVRRWHQRFLSLTEG
The following text describes a protein:
Function:
Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Also catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone (By similarity). Also has a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides.
Subcellular Localization:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Sequence:
MLSRVSVFKPASRGFSVLSSLKITEHTSAKHTEKPEHAPKCQNLSDAQAAFLDRVIRVDQAGELGADYIYAGQYFVLAHRYPHLKPVLKHIWDQEIHHHNTFNNLQLKRRVRPSLLTPLWKAGAFAMGAGTALISPEAAMACTEAVETVIGGHYNGQLRNLANQFNLERTDGTKGPSEEIKSLTSTIQQFRDDELEHLDTAIKHDSYMAVPYTVITEGIKTICRVAIWSAERI
The following text describes a protein:
Function:
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Subcellular Localization:
Host cytoplasm. Host nucleus.
Domain:
The N-terminal active domain blocks peptide binding to and peptide transport by TAP.
Sequence:
MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAPNASLGVAHRRTGGTVTDSPRNPVTR
The following text describes a protein:
Function:
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Subcellular Localization:
Nucleus.
Sequence:
MSDDAEVTNNKKTTKSTLLDGNHIFPPFYACYLLRSKATANSNRTYVGSTPDPPRRIRQHNGELKQGAWSTSRHRPWEMQMIVYGFPSKLAALQFEWAWQKPELSRHLRIRGEDQEYYHIFTKDARRNWVERKVCVAYALISLTPFNRLPLHVRFFNHETHGIWQSIHEQAGVNTIQRGKSRAKPVNPLHLLSQSVAPAVTIILDLGGVSGTSGKRRECTKGVMSHEGPIDVKDVEFRQGFGVRGKWLEIRKRILSGQDLCCHLCQERIAFNDHLTFSICPLAESQDCFCITHLICLAKHFQDEAPVEDRRAPSQPKILPYQGLCPNCKRTVQWGQHIRACYARKEQVEKAEKAEKAEKAEKAEKAEKAEKAEKAEKAEKAGRKVRQREMKTKKGDQSNGTVAQPESIYSATPVHTTFGLSNASATLIDPSMPARSMKSKDVGGEGIRHSTHTDDSDGIISVYSETEDESESEPEWEIFEAEMMALS
The following text describes a protein:
Function:
May glycosylate diterpenes or flavonols in leaves.
Sequence:
MANNTFAELVFIPAPAVGHVMSTIEMAKVLLNRDQTLSVTLLIIYPPYSYIESLAKNVIERIRFIKLPQDQPPSKLVSKAPFMSFYEFINSHCKYVRNILEDAINQIGSRRVVGLVVDILSMFSKPDRTSNRSSYRFSGPTGQTGHVYFTSNAAFLGFKLHFETLFVDQKQDLIELANSESEIVIPSFVNPVPMKVFPEVYQKQDGLDFLICAIGRIRKAKGILINTFLELETHVINWFSRINFPPVYLVGPILNLAGVSTAVFSARCLEQSGHRFVWSLRRLPPPEQSFQVFPDDFDDPRGVLPDGFLERTLGIGKVIGWAPQVSLLAHEAVGGFMSHCGWNSMLESLWFGVLMATLPMLWEQQMNAFEMVVELGLVVDLNSEGDVVIMMTKEIERGIRRLMENKEVRTKVKEMSKMSRETVVKGGSSHSFVGYLLKEIMSNVI
The following text describes a protein:
Function:
Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
Subcellular Localization:
Cell projection, dendrite. Cytoplasm. Mitochondrion. Nucleus.
Sequence:
MDPNQLERLRESQQKGLQSCDAKLERWAQFERDYESLCGRLDTLADRVTHEVMVPLNSLAFMPGRLVHTNEVLVLLGDNWFAQRSARQAFDIAKRRADQCRRMQRDLEKEKEQRSNWIKYTDELHRESACAEICEPYDPTEEEAWRERHRKSVRNYHRSKKDVRVGEGDKDVWAMLDRLEQQEERESASTSEEAASRKVRWQDESSVHITFSHSDTSLAETCAPAESTSTESIVMSPGDIFRMFGGSESGTTKSILKSPAEGAGRSVERAPPEVAEKPLWSARLERSRDDAFTGTVVEHDVQPPSDTTLDIDVTNVDIPQALSRPKSLFKSKRKAK
The following text describes a protein:
Function:
Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD). Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors. The geranylgeranyl pyrophosphate (GGPP) synthase AN1592 is needed in the formation of GGPP, the precursor for diterpenes. Lastly, the pimaradiene synthase pbcA performs the 2 cyclization steps that convert GGPP to ent-pimara-8(14),15-diene with ent-copalyl diphosphate as an intermediate. The putative roles of the remaining cluster enzymes in ent-pimara-8(14),15-diene biosynthesis is unclear (Probable). The cytochrome P450 monooxygenase AN1598, the glutathione S-transferase AN1595, the oxidoreductases AN1596 and AN1597 probably function as decorative enzymes (Probable). It is possible that in biological conditions the compound is oxidized to ent-pimara-8(14),15-dien-19-oic acid, which is a bioactive diterpene compound predominant in many plant extracts (Probable).
Domain:
The VYDTAW motif is widely conserved among diterpene cyclases in plants and fungi; The DXDD B-type cyclization motif at positions 328-331 is responsible for the formation of ent-CDP; The DEXXE A-type cyclization motif at positions 664-668 is responsible for the formation of ent-kaurene.
Sequence:
MTCADVTDLCTQASQLVQQLRTKDGELGFMSAAVYDTAWVSMVQKTTPEGRQWLLPKCFEYILRTQLEDGSWETYASDVDGILNTAASLLALETHAESRIASTDPPVEEMKERIGRARAALSRQLQAWSVKDTVHVGFEIILPALLRLLREKGHEFEFDGRAELDRLNRIKLSKFRPEYLYSARTTALHSLEAFVGMIDFDKVAHQKVNGSFMFSPSSTAAFLMFSSSWDDECEQYLRLVLQNGAGGGTGGMPSAYPSKYFEVSWVRGQLARLESKLTELQALTTLLDNGYSTGDLGIEDTDSLGEMLRDALVKGGGIVGFAPSIQADADDTAKSLIAVSLLDKPVSAQGLIDAFEGPMHFRTYHGERDPSFTANSNVLLALLNTPDAATVSPQIEKAAAFLCDVWWTADSEIGDKWNLSPYYPSMLMAEAFGKLLQVWSDGGLKSISSQFIRDRVSVCLYQALVRTLQTQNENGSWGSHSHEETAYAILTIAHACQLPVVNQLWTNVQLAVSRGRKFLQNSAGDKAEYLWVEKVTYSSILLSKSYVLAALKVSFERSYPACLANLFIVSKKRVIEFARFHSMLPLFSSMELWKVRAAIVEGYLLLPQLRDRRLAVFSRTGMEEDKYFEYIPFTWTLCNNRRNTFLSTKTLVEMMVISFLNYQADEFMEAVVGRLNSSQRSMTRSCIDEIFRDLKDKPELNDAIQAQSGPRNADANGHRILPQAKRIKMGSQLPSDVSRVLSAFVHHVMDHPSVKAAAPLEYERVKNELQVFLLSHIEQADDNGRFAAQLESTRDDFETARSSFYRWVSSTSSDHTSCPYSFAFYQCLLGFEQASHNAACFQTCEEKYVAEAMCRHLAVMCRMYNDYGSLARDRDEKNLNCVNFPEFAQAGPKSDAVRQKQLFSLAEFERSNMKRGLEVLTEMAAQDRAKMRMLEKVQMFCDVTDVYGQIYALEILRVGCDLAHDCFMLELPAQWSNST
The following text describes a protein:
Function:
Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
Sequence:
MQPFNLTATGYNLNYLPEYIALRHGFFREQGLDVTVTIPTPWDGVLDALADKTADMALGGIWVPSMYRSRVENYTVFAQIANRCPLALLTRSSAPKFQLTDVAGKTVLMKSGGGASVGLFFKMLLRENKIDERSVDYIQDLDGKMLGDLFEGGMGDYFVTDNLSALAMVAWNPNVCVAMEMVAQGDIPWSVYYAETAKITPELLDKQKRFCVALEKGIQWVLQHDANEFRDELAELFPNVPVDVAVGVTNGFRRDKMWTSTSVPRGGFERWQVGLAGARLVKEPLKYEEIVDDSLASTAAEMAGQVVAEP
The following text describes a protein:
Function:
Possible regulatory or functional link with the histocompatibility cluster.
Sequence:
MAPFSGKQKKKQLQEKRQRKKEQQNTESESKKRDEHGATEECNTQKYRQEGSSGAEHNSDSQHEKEEYKYGADRVGIRSVFLKETAEEVAERKKLSYERLANRHFMGPEGIPFGTWFNMPGPTKAAIIPLSVEIPTRGWSVDRVPMSKPNASDSMSDCNNSSNTDDVVDEVGDVLRDGPHVDAREQARFKEYVRALDNYSLPGEMQKLQVSSYERNIDVWRQLWRTVELSDVVIIVTDARYPVVHLPLSLLHYIVRECRKACVVVLNKADLVPPQTLNKWSEFLQSYFLTMGVVAASDEEATDTGIVREIPLVPFTALPSEETAIGTDTACDAMKRRKKKNRRNKLYEQLRTGKLQVCTDDSSDDGEEDDGDDLEKEISRLVPAAVAKGIVKGGDDESYAETDNFRGMRKAERELQRDRRDHKELQIVSNMISSLLQQCRDIGLSRRSAGSGNTSVTVHKCDRERGNEEDEEDEYIRIGFVGHPNVGKSSLLNCIRGTKVVSVSSTAGHTKHLQTIPIPSENVVLIDSPGLAFPVFGLPRPLQAVFGTHQIAQTRDPQSGVAYLATHLHLERLYGLSRSDYYDDDDDDEKSSRRHGPCGAPNVWSPYELCESYARKKGYFVKRGKGTLDVHRGAIELLQEAYEGRLVLFLSPPELSWLQSSEFNNEVRPYLLLRVMPLASSV
The following text describes a protein:
Function:
Necessary for the splicing of pre-mRNA. Probably active at the 3' splice sites.
Subcellular Localization:
Nucleus.
Sequence:
MAEHLASIFGTEKDRVNCPFYFKIGACRHGDRCSRLHTKPSISPTILLSNMYQRPDSITPGVDAQGNPIDPRKIQEHFEDFYEDLFEELNKYGEIESLNICDNLADHMVGNVYVQFREEEQAANALKNLTGRFYAGDRTAKANGKEEASAKRQRVVTRRPIIVDFSPVTDFREATCRQYEENVCNRGGYCNFMHLKKISRELRRQLFGRYRRRQSRSRSRSPYRHRSYEDRSHRSHSRKHDERDHYYESRSRRNRSTSPDHKRGRSRSPGGRRDRSPVRDGSEERRARIEQWNREKEQAELGNRANADSNYKNESNRNGSAPNQDQYYNQQ